NIH_SPENDING_CATS: Acquired Cognitive Impairment;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Dementia;Neurosciences;Pediatric;Social Determinants of Health

ORG_DEPT: PATHOLOGY

PHR: PI: Neena Singh PROJECT NARRATIVE The Research Immersion in Brain, Spinal cord (RIBS), and peripheral nerve disorders Program is designed to educate and immerse high school students from under-represented minority (URM) schools in a 8-week hands-on research experience in active laboratories on CWRU campus. The goal is to increase awareness of common neurological disorders, and build the confidence of young students to pursue careers in Neurological Research and Health care. Long-term student-mentor relationships will be an added benefit.

PI_NAMEs: SINGH, NEENA  (contact)

PROGRAM_OFFICER_NAME: MATTHEWS, MARGUERITE

PROJECT_TERMS: Admission activity;Affect;Age;age related;Alzheimer's Disease;Applied Research;Asian population;Awareness;Biological;Biomedical Engineering;Biomedical Research;Black Populations;Black race;Brain;Brain Diseases;brain health;career;Charge;Chronic;Clinical;college;College Admission Test;Communities;community engagement;Data;Dementia;design;Devices;Disease;disparity reduction;economic disparity;Economics;Education;Educational process of instructing;Educational Status;essays;experience;experimental study;Faculty;Feedback;Financial Support;Foundations;Functional disorder;Funding;Gifts;Goals;Graduation Rates;hands on research;Health;health care disparity;Healthcare;high school;High School Student;higher education;Hispanic;Hispanic Populations;Homelessness;Human Resources;Imaging technology;Immersion;improved;interest;Knowledge;Laboratories;Laboratory Personnel;Laboratory Research;Learning;Letters;Literature;matriculation;Medical center;medical schools;Medical Students;Memory;Mentors;metropolitan;Minority Groups;minority healthcare;National Institute of Neurological Disorders and Stroke;Nervous System;Nervous System Disorder;Neurologic;Neurologist;Neurosciences;Neurosurgeon;Outcome Measure;Paper;Parkinson Disease;Pathology;Patients;peer coaching;peripheral nerve damage;Peripheral Nerves;Play;Postdoctoral Fellow;posters;Principal Investigator;Prion Diseases;programs;Publications;Race;recruit;Reporting;Reproducibility;Research;Research Methodology;responsible research conduct;Rest;Role;school district;Schools;skills;socioeconomics;Special Education;Spinal Cord;Spinal Cord Diseases;Spinal Diseases;Stream;Stroke;Structure;student mentoring;student training;Students;Systemic disease;Technology;Therapeutic;three-dimensional modeling;Time;Tissues;Training;Traumatic brain injury related dementia;Underrepresented Minority;underrepresented minority student;Universities;University Hospitals;university student;virtual imaging;virtual reality;Work;Writing;Youth

PROJECT_TITLE: Research Immersion in Brain, Spinal cord (RIBS), & Peripheral nerves for URM High School Students

STUDY_SECTION_NAME: Special Emphasis Panel[ZNS1 SRB-D (27)]


ADMINISTERING_IC: AR

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Aging;Arthritis;Bioengineering;Chronic Pain;Clinical Research;Genetics;Human Genome;Nanotechnology;Osteoarthritis;Pain Research

ORG_CITY: ROCHESTER

ORG_COUNTRY: UNITED STATES

ORG_DEPT: ORTHOPEDICS

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF ROCHESTER

ORG_STATE: NY

PHR: PROJECT NARRATIVE Hip osteoarthritis (OA) is a painful joint disease and in the absence of disease-modifying drugs, OA is a tremendous burden on our healthcare system. The goal of this proposal is to delineate the functional role of the WNT Family Member 16 protein (WNT16) in hip OA using several novel and integrative single-cell multi-omics approaches. A detailed understanding of the disease mechanisms will provide significant insights into the development of early therapeutic interventions for hip OA.

PI_NAMEs: WU, CHIA-LUNG  (contact)

PROGRAM_OFFICER_NAME: ZHENG, XINCHENG

PROJECT_TERMS: Address;Affect;Age;aggrecan;Agonist;antagonist;arthropathies;Behavioral;Binding;Biology;Body mass index;Bone remodeling;Calcineurin;Cartilage;cartilage cell;cell fate specification;Cell Line;Cells;Chondrocytes;Chondrogenesis;Cleavage Under Targets and Release Using Nuclease;comparison control;conditional knockout;Cyclic AMP-Dependent Protein Kinases;Data;Data Set;Degenerative polyarthritis;Development;Disease;Encapsulated;Enhancers;Epigenetic Process;epigenetic regulation;Etiology;Exhibits;Family member;gain of function;Gases;Genes;Genetic;Goals;GTP-Binding Proteins;HDAC4 gene;Healthcare Systems;Hip Osteoarthritis;Hip region structure;Histology;Homeostasis;Human;human induced pluripotent stem cells;human stem cell-derived;Hypertrophy;inhibitor;Injury;insight;Ion Channel;knock-down;Knockout Mice;Knowledge;Link;loss of function;MAPK8 gene;Measurement;Measures;mechanical load;Mechanics;Mediating;Messenger RNA;microCT;Molecular;Morphology;mRNA delivery;multiple omics;Mus;myocyte-specific enhancer-binding-factor 2C;nanoparticle;next generation sequencing;novel;novel therapeutics;overexpression;Pain;Pathogenesis;Pathway interactions;Permeability;Persons;Pharmaceutical Preparations;Phenotype;Physiological;promoter;protein expression;Proteins;receptor;response;Role;Secondary to;Sepharose;Severities;Signal Pathway;Signal Transduction;Signaling Protein;single cell ATAC-seq;single-cell RNA sequencing;Small Interfering RNA;spatial integration;Specific qualifier value;Synovitis;Testing;therapeutic development;Therapeutic Intervention;therapy development;Time;Transcription Factor AP-1;transcriptome sequencing;transcriptomics;Vanilloid;WNT Signaling Pathway;Work

PROJECT_TITLE: WNT signaling in chondrocyte biology and osteoarthritis

STUDY_SECTION: SBDD

STUDY_SECTION_NAME: Skeletal Biology Development and Disease Study Section[SBDD]


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biomedical Imaging;Breast Cancer;Cancer;Prostate Cancer;Radiation Oncology;Urologic Diseases;Women's Health Research

ORG_CITY: CLEVELAND

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: Public Health Relevance/Narrative The role of SGLTs, one of the two types of transporters (molecular gates), to bring glucose (sugar) inside cancer cells is only now starting to be recognized. SGLTs can uniquely concentrate glucose inside cells and may also be used to concentrate therapeutic drugs in cancer cells to kill them without requiring high concentrations throughout the body which make patients sick. We will explore this potential using our new compound that can be labeled for fluorescent imaging, PET imaging, and radionuclide therapy.

PI_NAMEs: MUZIC, RAYMOND F (contact)

PROGRAM_OFFICER_NAME: WANG, YISONG

PROJECT_TERMS: Alkynes;analog;Animals;Biodistribution;Biological Assay;Biological Models;Brain;Breast;Breast Cancer Cell;Breast Cancer cell line;Breast Cancer Patient;Bronchogenic Carcinoma;cancer cell;Carbon;Cell Proliferation;Cell Survival;Cells;cellular imaging;Cervix Uteri;Cessation of life;Chemicals;Chemistry;Chemoresistance;chemotherapy;Clinical;Colon;Colon Carcinoma;Correlative Study;Data;Death Rate;Development;Diagnosis;Disease;Disseminated Malignant Neoplasm;dosimetry;External Beam Radiation Therapy;extracellular;Family;Fibroblasts;flexibility;fluorescence imaging;fluorodeoxyglucose;fluorophore;Genomics;Glucose;glucose analog;glucose metabolism;glucose transport;Glucose Transporter;Head and neck structure;Head Cancer;Heterogeneity;Human;Hypoglycemia;Image;imaging biomarker;Immunohistochemistry;In Vitro;in vivo;inhibitor;Iodine;Isotopes;Label;Length;Lung;Malignant Breast Neoplasm;Malignant neoplasm of brain;Malignant neoplasm of cervix uteri;Malignant neoplasm of lung;Malignant neoplasm of ovary;Malignant neoplasm of pancreas;Malignant neoplasm of prostate;Malignant Neoplasms;MDA MB 231;Measures;Mediating;Metastatic breast cancer;Metastatic Prostate Cancer;Methods;Microscopy;Modeling;Molecular;Mus;Neck Cancer;Neoplasm Metastasis;Normal tissue morphology;novel;Oncology;Operative Surgical Procedures;Ovary;overexpression;Pancreas;Patients;Penetration;personalized medicine;Pharmaceutical Preparations;Phenotype;Phosphorylation;Positioning Attribute;Positron-Emission Tomography;Primary Neoplasm;Prostate;prostate cancer cell line;protein expression;public health relevance;Radiation;Radionuclide therapy;Recurrence;Role;Skin;SLC2A1 gene;Sodium;Staging;sugar;targeted treatment;theranostics;Therapeutic;therapeutic target;Time;Tissues;tool;Toxic effect;treatment planning;treatment response;triple-negative invasive breast carcinoma;tumor;tumor heterogeneity;tumor microenvironment;Tumor Tissue;uptake;Work;Xenograft procedure

PROJECT_TITLE: Exploring SGLTs as Theranostic Targets for Cancer Metastasis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CTH-S (02)]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Social Determinants of Health;Women's Health Research

ORG_CITY: Nashville

ORG_DEPT: MISCELLANEOUS

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: Project Narrative Women are more likely to develop Alzheimer’s Disease and Related Dementias (ADRD) and suffer from cognitive decline in later life. Using high-quality longitudinal data collected in Ireland, the UK, and the USA, the proposed set of studies will investigate the role of employment as an unequally distributed resource for maintaining and enhancing cognitive health. Additional training in social determinants of ADRD, quantitative analytic methods, and survey measurement of cognitive outcomes will put me in an ideal position to become a successful independent investigator that will make major contributions to health disparities and aging research.

PI_NAMEs: KALOUSOVA, LUCIE  (contact)

PROGRAM_OFFICER_NAME: JAIN, KRITI MUNJAL

PROJECT_TERMS: Academic Medical Centers;Address;Adult;Affect;Age;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;American;analytical method;Area;Biological;Birth;British;Child;Childbirth;Cognitive;cognitive enhancement;cohort;Data;Data Set;Dementia;Disadvantaged;Discrimination;Disparity;Economics;Education;Employment;Epidemiology;Etiology;Exclusion;Family Leave;Foundations;Fracture;Funding;Gender;gender disparity;Gerontology;Goals;Health;Health and Retirement Study;health assessment;health data;health disparity;Home;Impaired cognition;Inequality;innovation;Interdisciplinary Study;Ireland;labor force participation;Labor Forces;late life;Lead;Left;Life;Life Cycle Stages;Life Expectancy;Life Style;Marriage;Maternity leave;Measurement;Measures;Medical;Memory;Mental Health;Mentored Research Scientist Development Award;Mentors;Mentorship;Michigan;Natural experiment;Nerve Degeneration;Neurosciences;older adult;Outcome;Pathway interactions;peer;Persons;physical conditioning;Physiological;Policies;Population;population health;Population Study;Positioning Attribute;Preparation;Probability;programs;Psychology;Quasi-experiment;Recording of previous events;Research;Research Personnel;Resources;Retirement;Risk;Role;Science;sex;Shapes;skills;social;social determinants;Social Network;social norm;Social Sciences;Societal Factors;structural determinants;Surveys;Time;tool;Training;United States;United States National Institutes of Health;Universities;Woman;Women's Role;Work

PROJECT_TITLE: Structural inequality in employment as a pathway for gender disparities in ADRD

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development For Early Career Investigators Study Section [AGCD-2]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cannabinoid Research;Clinical Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Social Determinants of Health;Substance Misuse

ORG_CITY: Riverside

ORG_NAME: EMMA PENDLETON BRADLEY HOSPITAL

ORG_STATE: RI

PHR: PROJECT NARRATIVE Cannabis use and related negative outcomes are disproportionately high among sexual minorities (SM) relative to their heterosexual counterparts; however, our knowledge of mechanisms portending these health risks is nascent. The goal of this K99/R00 is to leverage daily, real-time measures to examine minority stressors, cannabis use, negative outcomes, and psychosocial factors among SM individuals who use cannabis to evaluate putative mechanisms linking stressors to harmful outcomes. Identifying mechanisms underlying known health disparities will inform when and how cannabis use may be harmful, identify possible intervention targets, and facilitate future detailed examinations of the progression of cannabis use among SM.

PI_NAMEs: PARNES, JAMIE  (contact)

PROGRAM_OFFICER_NAME: ROMBERG, ALEXA RUTH

PROJECT_TERMS: acceptability and feasibility;Address;Adolescent;Alcohol consumption;Applications Grants;behavior change;Behavioral Mechanisms;biopsychosocial;Bisexual;Cannabis;Cognitive;cognitive process;Complement;coping;Cross-Sectional Studies;Data;design;Development;Disparity;Drug usage;Ecological momentary assessment;emotion dysregulation;ethnic identity;Evaluation;experience;Faculty;Funding;Future;Goals;Health;health disparity;Heterosexuals;Impairment;improved;Individual;Intervention;Knowledge;Lead;Legal;Life;Life Experience;Link;marijuana use;marijuana use disorder;Measures;Mediating;Mediation;Mediator;Mental Health;Mentorship;Methods;Minority;minority stress;minority stressor;Modeling;National Institute of Drug Abuse;Outcome;Participant;Phase;Population;Postdoctoral Fellow;Prevention;Process;Protocols documentation;psychological distress;Psychological Stress;Psychosocial Factor;Race;Reporting;Research;Research Personnel;response;Risk;sex;sexual minority;sexual minority group;sexual minority health;sexual minority health research;skills;social stigma;Statistical Data Interpretation;Statistical Models;stressor;substance use;Surveys;Testing;Text;theories;therapy development;Time;Training;usability;Work;young adult

PROJECT_TITLE: Using EMA to Examine Minority Stress Mechanisms Underlying Cannabis Use among Sexual Minorities

STUDY_SECTION: NIDA

STUDY_SECTION_NAME: Career Development Education and Training Study Section[NIDA-K]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: LOS ANGELES

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: Project Narrative The neocortex controls all high-level aspects of sensory perception, high level cognition and memory. The ques- tion addressed by the proposed studies, how cortical populations continuously adapt to different sensory envi- ronments, is a fundamental aspect of brain function. The proposed work addresses NIH’s mission to advance basic knowledge, medical science, and help reduce individual suffering and the societal burdens of developmen- tal disorders of the central nervous system.

PI_NAMEs: RINGACH, DARIO L (contact)

PROGRAM_OFFICER_NAME: FLANDERS, MARTHA C

PROJECT_TITLE: Cortical adaptation in neural populations

STUDY_SECTION: NBVP

STUDY_SECTION_NAME: Neuroscience of Basic Visual Processes Study Section[NBVP]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Data Science;Digestive Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Precision Medicine;Prevention

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE This project seeks to apply artificial intelligence techniques to electronic health records to advance research in diverticulitis, one of the most common gastrointestinal conditions for emergency department visits and hospital admissions. We propose to use natural language processing for clinical documentation and deep learning for imaging to build a prediction model for subsequent external validation to predict recurrence and long-term complications of diverticulitis. Our project will advance our understanding of factors predictive of diverticulitis outcomes and contribute to clinical care by generating a risk prediction model for risk stratification that will guide the appropriate management of the disease.

PI_NAMEs: MA, WENJIE  (contact)

PROGRAM_OFFICER_NAME: SASLOWSKY, DAVID E

PROJECT_TERMS: Abdomen;abdominal CT;Abscess;Address;adverse outcome;Affect;Age;Aging;Artificial Intelligence;artificial intelligence method;Biological;Biological Markers;career;Characteristics;Clinical;clinical care;Clinical Data;clinical decision support;Clinical Management;clinical predictors;Clinical Research;clinical risk;Code;cohort;Colectomy;Collection;Colon;comorbidity;Computational Technique;Data;Data Science;Data Set;Databases;Decision Making;deep learning;deep learning algorithm;Development;Diagnosis;Diagnostic;Digestive System Disorders;digital phenotyping;Disease;Disease Management;Disease Outcome;Diverticulitis;Diverticulosis;Documentation;electronic health information;Electronic Health Record;Emergency department visit;Epidemiologist;Epidemiology;Evaluation;Excision;experience;Family;Fistula;Future;Gastroenterologist;gastrointestinal;Goals;Grant;Guidelines;gut microbiome;gut microbiota;Healthcare;Hemorrhage;high risk;Hospitalization;Image;image processing;imaging informatics;improved;Inflammation;Inflammatory;Length;Life Style;lifestyle factors;Liquid substance;Machine Learning;machine learning method;machine learning prediction;Manuals;Medical;Medical Imaging;Medicine;Mentors;Mentorship;Mission;Modeling;multidisciplinary;National Institute of Diabetes and Digestive and Kidney Diseases;Natural Language Processing;novel;Obesity;Obstruction;Operative Surgical Procedures;Outcome;outcome prediction;Patients;Pattern;Perforation;Performance;persistent symptom;personalized approach;Positioning Attribute;precision medicine;Predictive Factor;predictive modeling;predictive tools;Predisposing Factor;Prognosis;prognostic;radiological imaging;radiologist;Recommendation;Recording of previous events;Recurrence;Reporting;repository;Research;Research Personnel;Risk;risk prediction;risk prediction model;risk stratification;routine practice;Severities;Severity of illness;skills;Strategic Planning;structured data;support tools;Techniques;Thick;Tobacco use;tool;Training;training opportunity;Uncertainty;Universities;unstructured data;Validation;Washington;Work;X-Ray Computed Tomography

PROJECT_TITLE: Prediction of outcomes in diverticulitis using a deep-learning framework

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Immunotherapy;Liver Disease;Mental Health;Neurosciences;Skin Cancer;Women's Health Research

ORG_CITY: BUFFALO

ORG_NAME: ROSWELL PARK CANCER INSTITUTE CORP

PHR: PROJECT NARRATIVE Breast cancer is the second leading cause of cancer death among women in the United States, with triple negative breast cancer (TNBC) being the most aggressive and deadly form, and the only breast cancer subtype where immunotherapy is approved. Psychosocial stress, experienced by a large majority of breast cancer patients, remains an understudied and underappreciated contributor to the development of aggressive disease and resistance to treatments, including immunotherapy. The proposed work will provide insights into a novel mechanism of psychosocial stress-induced immunosuppression and uncover promising approaches that could be translated for therapeutic benefit for patients with TNBC.

PI_NAMEs: GANDHI, SHIPRA  (contact)

PROGRAM_OFFICER_NAME: RADAEV, SERGEY

PROJECT_TERMS: Adrenergic Agents;Adrenergic beta-Antagonists;Aftercare;Agonist;Area;Beta Cell;beta-adrenergic receptor;biological adaptation to stress;Blood;Breast Cancer Patient;cancer cell;cancer clinical trial;Cancer Etiology;cancer subtypes;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Fraction;chemokine;chemotherapy;Chronic;Chronic stress;Clinical;Clinical Trials;Combined Modality Therapy;Comprehensive Cancer Center;Confocal Microscopy;CXC chemokine receptor 3;CXCL10 gene;CXCL9 gene;CXCR3 gene;Cytometry;Data;Development;Diagnosis;Dinoprostone;Disease;Down-Regulation;Endothelial Cells;Environment;Enzyme-Linked Immunosorbent Assay;Epinephrine;exhaustion;experience;Fibroblasts;Flow Cytometry;Gene Expression;Goals;Human;Hyperactivity;Image;Imaging Techniques;Immune;Immune checkpoint inhibitor;Immunooncology;Immunophenotyping;Immunosuppression;Immunotherapy;improved;insight;Institution;Interferon alpha;Interferon Type II;Interferon-beta;Interferons;K-Series Research Career Programs;Ligands;Liver;Macrophage;Malignant Breast Neoplasm;Measures;Mediating;Mediator;Melanoma;Melanoma patient;Mentorship;Messenger RNA;Metastatic Melanoma;Metastatic Neoplasm to the Liver;Minority;monocyte;Myeloid Cells;Myeloid-derived suppressor cells;Names;Natural Killer Cells;Neoplasm Metastasis;nerve supply;Norepinephrine;novel;novel strategies;Observational Study;Pathway interactions;Patient Selection;Patient Self-Report;Patients;pembrolizumab;perceived stress;pre-clinical;Production;programmed cell death ligand 1;Propranolol;prospective;Prostaglandin Inhibition;Prostaglandins;protein expression;Psychosocial Stress;recruit;Regimen;Regulatory T-Lymphocyte;Reporting;Resistance;resistance mechanism;response;RNA;Role;Running;Sampling;Scientist;Signal Transduction;Source;Stress;Stromal Cells;Sympathetic Nervous System;T cell infiltration;T-Lymphocyte;Testing;Therapeutic;Therapeutic Agents;therapeutic evaluation;Therapeutic Intervention;therapy resistant;Tissue imaging;Tissues;TLR3 gene;transcriptomics;Translating;translational scientist;Treatment/Psychosocial Effects;triple-negative invasive breast carcinoma;tumor;Tumor Bank;Tumor Immunity;tumor microenvironment;Tumor Tissue;tumor-immune system interactions;United States;Universities;Women's mortality;Work;young woman

PROJECT_TITLE: Stress-induced immunosuppression via downregulation of interferon in triple negative breast cancer

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Cancer;Clinical Research;Immunotherapy;Neuroblastoma;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_NAME: DANA-FARBER CANCER INST

PHR: PROJECT NARRATIVE: Children remain a vulnerable group against many illnesses and in particular disease processes that require therapeutic administration of immune modulating agents, (e.g. cancer treatment) have not been studied in the context of the immature immune system. The proposed studies from this application will directly investigate this fundamental gap in knowledge using cellular metabolism to identify mechanisms regulating immune cell development and response to the childhood cancer neuroblastoma. The long-term goal of these studies is to identify metabolic vulnerabilities unique to interactions between the pediatric immune system and childhood cancers to enhance immunotherapy, increase survival, and decrease treatment related toxicity in children with cancer.

PI_NAMEs: ROWE, JARED H. (contact)

PROGRAM_OFFICER_NAME: MAJJI, SAI PRASANNA

PROJECT_TERMS: Adult;Age;Alanine;Autoimmunity;Biology;Cancer Biology;cancer immunotherapy;Cancer Model;cancer therapy;Cause of Death;CD8-Positive T-Lymphocytes;Cell Physiology;Cells;Cellular biology;Cellular Immunology;Cellular Metabolic Process;Child;Child Health;Childhood;clinically relevant;Complex;critical period;Cytoprotection;Development;Developmental Process;Disease;Disparity;early childhood;Equilibrium;Foundations;Goals;Hostility;Immune;immune modulating agents;Immune response;Immune system;immune system function;Immunocompetent;Immunologics;Immunotherapy;Impairment;improved;In Situ;Individual;individualized medicine;Infection;inhibitor;innovation;juvenile animal;Knowledge;Life;Malignant Childhood Neoplasm;Malignant Neoplasms;Metabolic;Metabolic Control;Metabolic Pathway;Metabolism;metabolomics;Mus;Neonatal;neoplastic cell;Neuroblastoma;new therapeutic target;novel;Nutrient;Organism;Pathway interactions;Patient-Focused Outcomes;Pediatric Neoplasm;pediatric patients;Physiological;Pre-Clinical Model;prevent;Process;Proliferating;Property;Pyruvate;Pyruvate Metabolism Pathway;Regulation;Research;resistance mechanism;response;Role;Supplementation;Systems Biology;Systems Development;T cell regulation;T-Cell Activation;T-Cell Development;T-Lymphocyte;Therapeutic;Thymus Gland;Tissues;transcriptomics;Treatment-related toxicity;tumor;Tumor Escape;Tumor Immunity;tumor microenvironment;Tumor-Derived;Tumor-Infiltrating Lymphocytes;Vulnerable Populations

PROJECT_TITLE: Identifying metabolic regulation of T cells during early childhood development

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Developmental Biology Study Section[CHHD-C]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Genetics;Infectious Diseases;Neurosciences;Sexually Transmitted Infections

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: The mechanism by which Herpes Simplex Virus reactivates from a latent infection to cause disease is not known. This proposal will investigate viral gene expression during the initiation of reactivation and the role of the first viral protein identified that is required for exit from latency. The long-term goals are to understand how the virus co-opts cellular pathways for reactivation and ultimately identify novel therapeutic targets to prevent reactivation.

PI_NAMEs: CLIFFE, ANNA RUTH (contact)

PROGRAM_OFFICER_NAME: DUPUY, LESLEY CONRAD

PROJECT_TERMS: Address;Alzheimer's Disease;animation;Biological Assay;Body Surface;Cells;Cellular Stress;Cleavage Under Targets and Release Using Nuclease;Complex;Data;Dependence;Development;Disease;DNA biosynthesis;DNA-Directed RNA Polymerase;Encephalitis;Epigenetic Process;Event;Future;Gene Expression;Gene Expression Profile;Genes;Genetic Transcription;Genome;Goals;Heat shock proteins;Herpes Simplex Infections;Herpesvirus 1;in vitro Model;Individual;Infection;innate immune sensing;innovation;Integration Host Factors;Investigation;Keratitis;Knowledge;Late Onset Alzheimer Disease;latent infection;Lesion;Leucine Zippers;Link;Lytic;lytic gene expression;lytic replication;Lytic Virus;MAPK8 gene;Maps;Mitochondria;Mitochondrial DNA;Modeling;Morbidity - disease rate;mortality;N-terminal;Nerve Degeneration;Neuroglia;Neurons;new therapeutic target;novel;Nucleic Acids;Pathway interactions;Phase;Phosphotransferases;prevent;Process;Productivity;promoter;Protein Biosynthesis;Proteins;Resolution;RNA;Role;Simplexvirus;Stimulus;Testing;Therapeutic;therapeutic candidate;therapeutic development;Time;Transcript;transcriptome sequencing;Viral;viral DNA;Viral Genes;Viral Proteins;Virus;Virus Activation;Virus Replication;VP 16

PROJECT_TITLE: Role for UL12.5 and nucleic acid sensing in Phase I HSV reactivation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 VDT-Q (01)]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Conditions Affecting the Embryonic and Fetal Periods;Contraception/Reproduction;Diabetes;Dissemination and Implementation Research;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Women's Health Research

ORG_CITY: WORCESTER

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: Project Narrative Gestational diabetes mellitus (GDM) is one of the most common complications of pregnancy and is associated with significant negative consequences for the maternal-offspring dyads. Professional societies recommend screening for GDM; however, guidance is inconsistent and late in pregnancy, thus precluding meaningful time to intervene for maternal-offspring benefit. Early approaches to GDM screening relying on clinical biomarkers in the first trimester exist, and this study will create a protocol for implementation of enhanced first trimester GDM screening and perform a feasibility and acceptability trial in the first trimester among high-risk pregnant women.

PI_NAMEs: WILKIE, GIANNA LUSIYE (contact)

PROGRAM_OFFICER_NAME: MITCHELL, MEGAN S

PROJECT_TERMS: acceptability and feasibility;adverse outcome;Affect;American College of Obstetricians and Gynecologists;Award;Biological Markers;biomarker performance;Birth trauma;Birth Weight;care providers;Caring;Cesarean section;Child;Clinical;clinical biomarkers;clinical implementation;clinical practice;clinical predictive model;Clinical Research;clinical risk;Clinical Trials Design;Consensus;Consumption;Control Groups;Detection;Development;Diabetes Mellitus;diabetes risk;Discipline of obstetrics;Early Diagnosis;early pregnancy;early screening;Early treatment;Effectiveness;Eligibility Determination;Environment;feasibility testing;Feedback;First Pregnancy Trimester;Focus Groups;Funding;Future;Gestational Age;Gestational Diabetes;Glucose;glycemic control;Glycosylated hemoglobin A;Goals;group intervention;high risk;High Risk Woman;High-Risk Pregnancy;Hypertension;implementation protocol;implementation science;implementation trial;improved;Infant;infant outcome;Insulin Resistance;intergenerational;Intervention;K-Series Research Career Programs;Knowledge;LCN2 gene;Leadership;Life;Life Style;Massachusetts;maternal morbidity;Maternal Mortality;medical schools;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Methods;Modeling;mortality;multidisciplinary;Neonatal Hypoglycemia;neonatal morbidity;Non-Insulin-Dependent Diabetes Mellitus;Obesity;obstetric care;offspring;OGTT;Oral;Outcome;Participant;Patient-Focused Outcomes;Patients;Perinatal Care;perinatal outcomes;personalized approach;Physicians;Population;Pre-Eclampsia;predictive modeling;Pregnancy;Pregnancy Complications;pregnancy disorder;Pregnancy in Diabetics;Pregnancy-Associated Plasma Protein-A;pregnant;Pregnant Women;Premature Birth;Prenatal care;prenatal health;primary outcome;Professional Organizations;Protocols documentation;Provider;Randomized;Randomized, Controlled Trials;Recommendation;Recording of previous events;Research;Research Methodology;Risk;Risk Factors;routine screening;Scientist;screening;screening guidelines;secondary outcome;Serum;Site;skills;standard of care;stillbirth;Testing;Time;Training;trend;Triglycerides;Universities;Woman;Work;Writing

PROJECT_TITLE: Early Detection of Gestational Diabetes Mellitus in Pregnancy

STUDY_SECTION_NAME: Obstetrics and Maternal-Fetal Biology Study Section[CHHD-B]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: SAINT LOUIS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative This mentored career development proposal aims to train and mentor the principal investigator at a critical junction in training. One primary component is focused on the development of the principal investigator into a physician scientist who will be uniquely trained to identify and address clinically and scientifically relevant questions to improve the care of cardio-oncology patients. A second component is focused on identifying mechanisms of cardiac injury and remodeling as a result of cancer immunotherapies that regulate immune checkpoints.

PI_NAMEs: JIMENEZ, JESUS  (contact)

PROGRAM_OFFICER_NAME: HUANG, LI-SHIN

PROJECT_TERMS: Acceleration;Address;Agonist;Angiotensin II;Antibodies;Antigen Presentation;Antigen-Presenting Cells;Arrhythmia;autoimmunity checkpoint;B-Lymphocytes;beta-Chemokines;Bioinformatics;Biological Assay;cancer immunotherapy;Cancer Model;Cancer Patient;cancer therapy;Cardiac;Cardiomyopathies;Cardiovascular Diseases;Cardiovascular system;career development;Caring;CD40 Ligand;Cell Surface Proteins;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Characteristics;chemokine;chemokine receptor;Clinical;clinical practice;clinical training;Clinical Trials;Competence;conditional knockout;CTLA4 blockade;cytokine;cytotoxic;Data;Dendritic Cells;Development;Development Plans;Doctor of Philosophy;Eligibility Determination;Evaluation;Event;Fatality rate;Fellowship;Flow Cytometry;Gene Expression;Genetic;Goals;Grant;Heart;Heart Injuries;Immune;immune checkpoint;Immune checkpoint inhibitor;Immune response;Immunology;Immunotherapy;Impairment;improved;Infiltration;Inflammation;Inflammatory;Inflammatory Response;Infusion procedures;inhibitor therapy;Injections;Injury;innovation;insight;Integral Membrane Protein;Interferon Gamma Receptor Complex;Interferon Type II;Internal Medicine;Knockout Mice;Left Ventricular Remodeling;Ligands;Macrophage;Macrophage Activation;Malignant Neoplasms;Manuscripts;Mediating;Mediator;member;Mentors;Mentorship;Mus;Myocardial;myocardial injury;Myocarditis;Oncology;Outcome;Patients;PD-1 inhibitors;PD-L1 blockade;Phenotype;Phenylephrine;Physicians;Postdoctoral Fellow;Preparation;Principal Investigator;Production;programmed cell death protein 1;programs;protein expression;receptor;recruit;Research;response;Role;Scientist;Shapes;Signal Transduction;single cell sequencing;skills;T cell response;T memory cell;T-Cell Activation;T-Lymphocyte;T-Lymphocyte Subsets;targeted cancer therapy;Technical Expertise;Testing;Tissues;TNF gene;TNFRSF5 gene;Training;tumor;Writing

PROJECT_TITLE: CD40 Immunotherapy Effect on the Cardiac Immune Landscape and Response to Myocardial Disease

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS (OA)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Mental Health;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: BALTIMORE

ORG_DEPT: PSYCHIATRY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Narrative Resilience, characterized as the capacity to recover quickly from highly stressful or traumatic experiences, may lessen the gravity of negative consequences of opioid use disorder (OUD). This study seeks to achieve a better understanding of resilience through the development of a human laboratory model that integrates measurement of psychobiological components of resilience (e.g., emotional flexibility – the ability to flexibly regulate emotions in a context-appropriate manner) with behavioral measures of stress reactivity (e.g., heroin demand on the heroin purchase task – a proxy for heroin self-administration). Developing a laboratory model of resilience will permit investigating whether resilience is stable and if it can be improved—a prerequisite to measure the effects of any new intervention targeting resilience.

PI_NAMEs: MARTINEZ, SUKY  (contact)

PROGRAM_OFFICER_NAME: MOLLICK, JESSICA ANN

PROJECT_TERMS: Acute;Address;adverse outcome;Affective;American;Award;Behavior;behavior measurement;Behavioral;biological adaptation to stress;Blood Pressure;career;Categories;Clinical;Cognitive;Complement;Complex;Computer Models;Coping Skills;craving;Data;Decision Making;design;Development;Diagnosis;Differential Diagnosis;Dimensions;discounting;Disease;Drug Kinetics;DSM-V;Economics;Emotional;emotional functioning;Emotions;Epigenetic Process;Etiology;experience;flexibility;Force of Gravity;Funding;Future;Galvanic Skin Response;Genetic;Goals;Grant;Heart Rate;heart rate variability;Heroin;heroin use;Heterogeneity;Human;Impaired cognition;improved;Incidence;Individual;Inpatients;insight;instrument;Intervention;Investigation;Investments;Laboratories;Laboratory Procedures;Laboratory Study;Maintenance;Manuscripts;Measurement;Measures;Mentors;Methodology;Modeling;Morphine;novel;novel diagnostics;Opioid;opioid overdose;opioid use disorder;Oral;Participant;Pathway interactions;Patient Self-Report;perceived stress;personalized intervention;Pharmaceutical Preparations;Phenotype;Physiological;Positioning Attribute;Prevalence;Process;Proxy;psychobiologic;psychologic;Psychological Stress;Psychologist;Psychometrics;Psychopathology;Randomized;recruit;Research;Research Design;resilience;resilience research;resilience scale;Resources;response;Role;Scientist;Self Administration;Severities;skills;sound;Statistical Methods;Stress;stress reactivity;Symptoms;Testing;theories;therapeutic target;tool;Training;Trier Social Stress Test;Validation;Withdrawal Symptom

PROJECT_TITLE: A Novel Human Laboratory Model of Resilience Among Individuals with Opioid Use Disorder

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BP-Q (02)]


ORG_CITY: NEW YORK

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: Project Narrative Recent studies have shown that genetic changes explain only 50% of lung cancer disease progression, strongly suggesting there are unidentified, non-genetic mechanisms that are driving drug resistance and metastasis. In preliminary experiments, we have identified that propionate metabolism, a pathway previously not known to play a role in cancer, is dysregulated in lung cancer, and its dysregulation can drive drug resistance and metastatic programs. This proposal aims to improve our understanding of propionate metabolism in lung cancer by defining the mechanisms and consequences of its dysregulation, potentially identifying a new pathway that can be targeted therapeutically.

PI_NAMEs: PARANG, BOBAK  (contact)

PROGRAM_OFFICER_NAME: BOULANGER-ESPEUT, CORINNE A

PROJECT_TERMS: 3-Dimensional;Acceleration;Age;age related;Amino Acids;anti-cancer research;Automobile Driving;Binding;Biology;Cancer Biology;cancer cell;Cancer cell line;cancer drug resistance;Cancer Etiology;Cancer Model;carcinogenesis;career;career development;Cell Culture Techniques;Cells;Cessation of life;Cholesterol;Citric Acid Cycle;Clinical;Clinical Oncology;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;CRISPR/Cas technology;Data;Data Set;Dedications;Development Plans;Diagnosis;Disease;Disease Progression;DNA sequencing;Drug resistance;Dysplasia;Environment;Enzymes;epithelial to mesenchymal transition;experimental study;Fatty Acids;Funding;G-Protein-Coupled Receptors;Genetic;Goals;GTP-Binding Proteins;improved;in vivo;Institution;knock-down;KRASG12D;Laboratories;LoxP-flanked allele;lung cancer cell;Malignant neoplasm of lung;Malignant Neoplasms;Measures;Medical Oncology;Medicine;Mentorship;Messenger RNA;Metabolic;Metabolic Pathway;Metabolism;metabolomics;Methylmalonic Acid;Modeling;Molecular Biology;mortality;mouse model;Mus;Mutation;Neoplasm Metastasis;non-genetic;Non-Malignant;Non-Small-Cell Lung Carcinoma;novel;novel therapeutics;Pathway interactions;Patients;Persons;pharmacologic;Phenotype;Physicians;Play;Positioning Attribute;Process;programs;Propionates;Proteins;Receptor Signaling;Regulator Genes;Research;Resected;Resistance;RNA Interference;Role;Scientist;Serum;Signal Pathway;Signal Transduction;Signaling Molecule;skills;Structure of parenchyma of lung;targeted treatment;Technical Expertise;Testing;Training;Training Programs;transcriptome sequencing;tumor;Tumor Burden;tumor metabolism;tumor progression;Tumor Promotion;United States;Work

PROJECT_TITLE: The Role of Propionate Metabolism in Non-Small Cell Lung Cancer


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: UNIVERSITY PARK

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

ORG_STATE: PA

PHR: Narrative The Amish, as a persistently high fertility population in a low fertility context, offer a present-day opportunity to explore theories addressing why and how birth rates change and, by extension, the heavy investment of women in carrying and bearing children. Furthermore, because of their rapid population growth and preference for rural areas, especially in declining and depopulating regions, many Amish people are underserved, yet have an outsized impact on those rural healthcare systems and public infrastructures that are present. Finally, understanding how Amish fertility is responsive to internal and external mechanisms is important for understanding how, where, and why the Amish population is growing.

PI_NAMEs: ANDERSON, CORY  (contact)

PROGRAM_OFFICER_NAME: POPKIN, RONNA

PROJECT_TERMS: Address;Age Distribution;Agriculture;American;Amish;Area;Articulation;Birth;Birth Intervals;Birth Rate;Books;career preparation;Censuses;Cessation of life;child bearing;Communities;contextual factors;Couples;Cross-Sectional Studies;Data;Data Set;Data Sources;database design;Database Management Systems;database structure;Databases;Death Rate;Decision Making;Demographic Transitions;Demography;Development;Directories;Documentation;Economic Development;Economics;Education;Encapsulated;Environment;Equation;Ethnic Origin;Event;Exposure to;Fertility;Fertility Incentive;Geography;Goals;Health;Health behavior;health care availability;Healthcare Systems;High Fertility Populations;Household;Household Heads;improved;Incentives;Individual;Infrastructure;Investments;Knowledge;Life Cycle Stages;Life Tables;Link;Location;longitudinal analysis;longitudinal database;Marriage;migration;Minority;Modernization;multilevel analysis;Neighborhoods;North America;Nuptiality;Occupational;Occupations;Out-Migrations;Phase;Population;Population Database;Population Density;Population Growth;population health;preference;Process;Publications;rate of change;Records;Registries;relational database;Religion;Research;Research Personnel;rural area;rural healthcare;Series;Sex Distribution;Site;social;social culture;social factors;Societies;socioeconomic development;socioeconomics;Statistical Data Interpretation;Structure;success;Testing;theories;Time;Time trend;Training;Training Programs;trend;Underserved Population;Variant;Vital Statistics;Woman;Work

PROJECT_TITLE: Understanding fertility trends in a cohesive high-fertility population within a low-fertility environment

STUDY_SECTION_NAME: Population Sciences Study Section[CHHD-W]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Dietary Supplements;Drug Abuse (NIDA only);Nutrition;Pregnancy;Prevention;Substance Misuse;Tobacco;Tobacco Smoke and Health;Women's Health Research

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

PHR: PROJECT NARRATIVE Our brains are hard-wired to prioritize the present over the future—a tendency called delay discounting that often leads us to choose immediate gratification even when we know it is not in our long-term interests. For pregnant women who smoke, the immediate rewards of a cigarette can overwhelm efforts to resist the temptation to smoke, despite most women wanting to quit for both their own and their baby's sake. Among pregnant women who smoke, this study will (1) measure delay discounting using a newly developed method that mimics the experience of addiction, (2) characterize how delay discounting affects smoking during and after pregnancy, and (3) building on evidence from animal and clinical research, test whether high-dose dietary supplementation of omega-3 polyunsaturated fatty acids reduces delay discounting.

PI_NAMEs: LEE, SCOTT  (contact)

PROGRAM_OFFICER_NAME: FEDOTA, JOHN RAPHAEL

PROJECT_TERMS: Abstinence;addiction;Addictive Behavior;Address;Affect;Animal Experimentation;Animal Model;Award;Behavior;behavior change;Behavioral;behavioral economics;Biomedical Research;Brain;career;career development;Cellular Phone;Cigarette;cigarette smoke;Clinical;Clinical Research;Clinical Trials;Cognitive;Competence;Development Plans;dietary;Dietary Supplementation;Dimensions;discount;discounting;Dose;endophenotype;Equation;Exhibits;experience;Face;fatty acid supplementation;Funding;Future;Genetic;Human;Impulsive Behavior;Impulsivity;indexing;instrument;Intention;interest;Intervention;K-Series Research Career Programs;Knowledge;Light;Link;Low Birth Weight Infant;Measurement;Measures;Mediating;Mentors;Mentorship;Methods;Modeling;N-3 polyunsaturated fatty acid;Neonatal Mortality;Neural Pathways;Neurobiology;Neurosciences;new therapeutic target;Nicotine Dependence;novel;novel strategies;Omega-3 Fatty Acids;Outcome;Parents;pharmacologic;Pharmacotherapy;Physical Efforts;Placebos;Positioning Attribute;post pregnancy;Postpartum Period;Pregnancy;Pregnant Women;Premature Birth;prenatal cigarette smoking;prevent;Productivity;Reducing Agents;Reporting;Research;Research Activity;Research Personnel;Rewards;Risk;risk prediction;Role;Safety;Sampling;Science;Secure;Signal Transduction;skills;Smoke;Smoking;smoking cessation;Smoking Cessation Intervention;Spontaneous abortion;Structure;Substance Use Disorder;Supplementation;Testing;Therapeutic;therapeutic target;Time;Tobacco use;Training;Training Activity;United States;United States National Institutes of Health;Vacuum;virtual;willingness;Woman

PROJECT_TITLE: Measuring and modifying delay discounting as a mechanism of smoking in pregnancy

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Emergency Care;Health Services;Mental Health;Mental Illness;Prevention;Suicide;Suicide Prevention;Telehealth

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE The proposed project will address a critical need for effective and scalable intervention approaches for adults presenting with suicide-related concerns to Emergency Departments (EDs), many of whom remain at high risk for suicidal behavior following ED discharge. Using a two-arm randomized controlled trial with an embedded micro-randomized trial (MRT), the project will obtain key data on feasibility, acceptability, and initial impact on hypothesized mechanisms to inform an effective technology-augmented intervention package, including ED- initiated safety planning and adaptive post-discharge text messages. Findings from this study will provide the necessary groundwork for a scalable and resource-efficient intervention targeting reduction in suicidal behavior during the high-risk transition after ED care.

PI_NAMEs: CZYZ, EWA KARINA (contact);HORWITZ, ADAM GABRIEL

PROGRAM_OFFICER_NAME: PUGLIESE, CARA ELISABETH

PROJECT_TERMS: 2 arm randomized control trial;acceptability and feasibility;Accident and Emergency department;Acute;adaptive intervention;Address;Adult;Ambulatory Care;arm;Beds;brief intervention;Cause of Death;Clinical;Continuity of Patient Care;coping;Coping Behavior;Coping Skills;cost;Data;design;Distal;Electronics;Emergency Care;Emergency Department patient;Emergency department visit;experience;Feedback;Feeling suicidal;follow-up;Frequencies;future implementation;health belief;Health system;high risk;improved;Individual;innovation;Intervention;Link;Modeling;Motivation;negative affect;novel strategies;Outcome;Participant;Patients;Pilot Projects;Practice Guidelines;Prevention;preventive intervention;primary outcome;programs;Provider;Psychiatric therapeutic procedure;Public Health;Randomized;randomized trial;Recommendation;Recurrence;reducing suicide;remote delivery;Resources;Risk;Safety;Sample Size;Self Efficacy;Series;Services;Severities;Structure;suicidal;suicidal behavior;suicidal morbidity;suicidal risk;Suicide;Suicide attempt;Suicide prevention;Technology;technology platform;Text;Text Messaging;text messaging intervention;texting support;therapy development;Time;United States;Work

PROJECT_TITLE: Facilitating effective coping to reduce suicide risk following ED discharge: A micro-randomized trial to develop an adaptive text-based intervention

STUDY_SECTION: SERV

STUDY_SECTION_NAME: Mental Health Services Study Section[SERV]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Emerging Infectious Diseases;Gene Therapy;Genetics;Hematology;Infectious Diseases;Rare Diseases;Regenerative Medicine;Sickle Cell Disease;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Umbilical Cord Blood/ Placenta;Stem Cell Research - Umbilical Cord Blood/ Placenta - Human

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: Narrative The proposed research will have a high impact in the field of medicine, as it will develop new prototype vectors able to deliver the Prime Editor system efficiently, leading to the production of safer modified cells. In addition, this research is relevant to public health, and it will have a meaningful impact on developing new regenerative medicine and gene therapy approaches to treat monogenic diseases and other genetic diseases.

PI_NAMEs: DEVAUX, PATRICIA  (contact)

PROGRAM_OFFICER_NAME: DARINGER, NICHOLE MARIE

PROJECT_TERMS: Adult;BCL11A gene;Biomedical Research;Bone Marrow;cell type;Cells;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;Communities;CRISPR/Cas technology;curative treatments;Cytoplasm;Data;delivery vehicle;Dependovirus;Development;Disease;Disease-Free Survival;DNA;DNA Sequence;Elements;Enhancers;Enzymes;Erythroid;Fetal Hemoglobin;Fibroblasts;Future;GATA1 gene;Gene Delivery;gene editing technology;Gene Expression;Gene Modified;gene therapy;Generations;Genes;Genetic Diseases;genetic information;genetic manipulation;Genome;genomic locus;Genomics;genotoxicity;Goals;graft vs host disease;Guide RNA;Hematological Disease;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;high risk;Human;Immunosuppression;in vivo;induced pluripotent stem cell;Infection;innovation;insertion/deletion mutation;Insertional Mutagenesis;Knock-in;Lentivirus;Measles;Measles virus;Medicine;Mendelian disorder;Methods;Mismatch Repair;Modification;Mutation;nanoparticle delivery;next generation;novel;novel strategies;nuclease;Nucleotides;Oligonucleotides;Other Genetics;Outcome;overexpression;Patients;Phase;Plasmid Cloning Vector;prime editing;prime editor;Process;Production;programs;Proteins;prototype;Public Health;Regenerative Medicine;repaired;Reporting;Research;Reverse engineering;Risk;RNA;RNA Viruses;RNA-Directed DNA Polymerase;Siblings;Sickle Cell Anemia;sickling;Site;System;Technology;Testing;Transgenes;Transplantation;tumorigenesis;United States;Vaccines;vector;viral DNA;Viral Vector;Work

PROJECT_TITLE: Next generation of delivery platform for Prime editors based on an RNA vector for Sickle cell disease: the “all-in-one” vector

STUDY_SECTION: DBTD

STUDY_SECTION_NAME: Drug and Biologic Therapeutic Delivery Study Section[DBTD]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Burden of Illness;Caregiving Research;Clinical Research;Dementia;Health Services;Neurodegenerative;Neurosciences;Palliative Care

ORG_CITY: PROVIDENCE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: BROWN UNIVERSITY

PHR: PROJECT NARRATIVE This research is relevant to public health because it has the potential to provide valuable empirical evidence to inform hospice payment reforms, given the increasing attention to hospice regulation, accommodating hospice policies to fit the care needs of beneficiaries with non-cancer diagnoses, and the restructuring of hospice payment systems by care settings. This project is particularly relevant to the mission of the NIA because it capitalizes on existing national administrative healthcare data and aims to improve end-of-life care among older adults with Alzheimer’s and Related Dementia (ADRD).

PI_NAMEs: WANG, XIAO  (contact)

PROGRAM_OFFICER_NAME: KELLER, CHANDRA

PROJECT_TERMS: Address;Adult;Alzheimer's disease related dementia;Assisted Living Facilities;Attention;beneficiary;care systems;Caring;Characteristics;Clinical;Collaborations;Communities;Complex;Data;Data Reporting;dementia care;Diagnosis;Disease;end of life;end of life care;Enrollment;experience;Family;financial incentive;Foundations;Goals;Growth;Health Personnel;Healthcare;Healthcare Systems;Hospice Care;hospice environment;Hospice Programs;hospice utilization;hospital readmission;Hospital Referrals;Hospitalization;improved;Individual;innovation;insight;Knowledge;Length;Life;Light;Long-Term Care;Marketing;Measures;Medicare;Mission;Modification;Natural experiment;Neighborhoods;non-verbal;Nursing Homes;nursing skill;older adult;Outcome;Pain;Patients;Pattern;payment;Performance;Persons;Policies;preference;prevent;Public Health;Quality of Care;Reading;Regulation;Reporting;Research;Research Project Grants;response;Site;skills;Structure;Surveys;Time;trend;Visit

PROJECT_TITLE: Do Hospices Specializing in Long-Term Care Settings Provide Better Care to Beneficiaries with Alzheimer's and Related Dementia?

STUDY_SECTION: ODHS

STUDY_SECTION_NAME: Organization and Delivery of Health Services Study Section[ODHS]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Child Abuse and Neglect Research;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Mental Health;Pediatric;Prevention;Social Determinants of Health;Substance Misuse;Substance Misuse Prevention;Underage Drinking;Violence Research;Youth Violence

ORG_NAME: RHODE ISLAND HOSPITAL

PHR: PROJECT NARRATIVE The proposed research will fill a gap by testing iTRAC-SU, a web-based, integrated substance use and emotion regulation training intervention, with adolescents involved with child welfare, to determine impact on substance use, as well as emotion regulation abilities, mental health symptoms, and other risk behavior outcomes. This application addresses the Office of Disease Prevention and Health Promotion’s Healthy People 2030 objectives to reduce the proportion of adolescents who report use of alcohol, marijuana, or illicit drugs during the past 30 days (SU-04, 05, 06) and to increase the proportion of children and adolescents who show resilience to challenges and stress (EMC-D07).

PI_NAMEs: HOUCK, CHRISTOPHER D. (contact);PARADE, STEPHANIE HART

PROGRAM_OFFICER_NAME: DIULUS, KYLEE MAE PROBERT

PROJECT_TERMS: acceptability and feasibility;Address;Adolescence;Adolescent;adolescent substance use;Age;Alcohol consumption;Area;Awareness;behavior change;behavioral outcome;Caregivers;Child;Child Abuse and Neglect;Child Welfare;Collaborations;Communities;comparison group;Competence;Comprehension;cost;design;Development;digital;disorder prevention;distress tolerance;early adolescence;Early Intervention;Early-life trauma;Educational Intervention;Educational process of instructing;Effectiveness;efficacious intervention;efficacy trial;emotion regulation;Emotional;Emotions;Ensure;Exhibits;experience;Face;Family;Feedback;follow-up;Goals;Health;health communication;Health education;Health Promotion;Hybrids;Illicit Drugs;Impairment;improved;information gathering;innovation;Internet;Interruption;Intervention;Interview;life span;Link;maltreatment;Marijuana;Measures;Mediating;Mental Health;Mission;Modeling;neglect;neurotoxic;Online Systems;Outcome;Participant;Patient Self-Report;Performance;Persons;Phase;Population;Prevention;preventive intervention;Procedures;programs;psychosocial;Public Health;Randomized;randomized trial;Randomized, Controlled Trials;Recording of previous events;recruit;reduced substance use;Reporting;Research;resilience;Resources;respiratory;Rhode Island;Risk;Risk Behaviors;Risk Factors;Sampling;Self Efficacy;Sexual Health;sexual risk behavior;Sinus Arrhythmia;skills training;Stress;substance use;substance use prevention;success;Symptoms;System;Tablets;technological innovation;technology platform;Testing;Training;Translating;uptake;usability;Vulnerable Populations;Waiting Lists;Work;Youth

PROJECT_TITLE: Emotion Regulation Intervention to Prevent Substance Use Among Youth in the Child Welfare System

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 SAI-E (O1)]


NIH_SPENDING_CATS: Clinical Research;Infant Mortality;Kidney Disease;Lung;Machine Learning and Artificial Intelligence;Neonatal Respiratory Distress;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Rare Diseases

ORG_CITY: INDIANAPOLIS

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Project Narrative In the US 50,000 infants each year are born less than 28 weeks of gestation, and severe bronchopulmonary dysplasia (BPD) poses a tremendous health and economic burden in these infants. This foundational work seeks to improve severe BPD prediction by a) focusing on kidney-based risk factors of acute kidney injury and fluid overload and b) identifying critical biomarker candidates. Improving severe BPD predication with kidney- based risk factors and biomarkers will facilitate individualized fluid management and improved AKI detection and treatment, decreasing the diagnosis and severity of BPD in prematurely born infants.

PI_NAMEs: STARR, MICHELLE C (contact)

PROGRAM_OFFICER_NAME: SOOD, BEENA G

PROJECT_TERMS: Acute Renal Failure with Renal Papillary Necrosis;angiogenesis;Angiopoietin-2;bench to bedside;Biological Markers;Biometry;Bronchopulmonary Dysplasia;candidate marker;career;career development;Caring;Chronic;Clinical;clinical biomarkers;Clinical Data;Clinical Markers;clinical predictive model;Clinical Trials;Clinical Trials Design;cohort;comorbidity;Data;Death Rate;Detection;Development;Development Plans;Diagnosis;diagnostic accuracy;Early Diagnosis;Early identification;Economic Burden;Education;Erythropoietin;extreme prematurity;Faculty;Fluid overload;Foundations;Funding;Future;Goals;Grant;Health;Health Services Research;high risk;high risk infant;Hospitalization;Impairment;improved;Incidence;Infant;Intervention;Kidney;Kidney Diseases;Knowledge;Length of Stay;Link;Liquid substance;Lung;lung development;Lung Diseases;Machine Learning;machine learning algorithm;Mechanical ventilation;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Methods;Modeling;modifiable risk;Monitor;Morbidity - disease rate;mortality risk;multidisciplinary;National Heart, Lung, and Blood Institute;Neonatal;neonatal period;nephrogenesis;neuroprotection;novel;novel strategies;Organ;Outcome;Pattern;Plasma;predictive marker;predictive modeling;Pregnancy;Premature Infant;prevent;Prevention;programs;Public Health Informatics;Publishing;repaired;Research;Research Personnel;Research Project Grants;respiratory;Risk;Risk Factors;Severities;Survivors;Testing;translational approach;Treatment Protocols;United States;Update;urinary;Vascular Endothelial Growth Factor D;Vascular Endothelial Growth Factors;Work

PROJECT_TITLE: Improving the prediction of bronchopulmonary dysplasia by identifying kidney-based risk factors

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR (OA)]


NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Disability Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric

ORG_NAME: HUGO W. MOSER RES INST KENNEDY KRIEGER

PHR: PROJECT NARRATIVE Gastrointestinal (GI) symptoms are common and disabling among autistic children and adults, yet there are important limitations to existing measures of GI symptoms for this population. The proposed research will focus on the development, refinement, and psychometric evaluation of four versions (self-report and parent-report versions of pediatric and adult measures) of a novel questionnaire, the Autism Gastrointestinal and Related Behaviors Inventory (GIRBI). These measures will help promote rigorous epidemiology of gastrointestinal dysfunction, timely screening and diagnosis of GI conditions in research and clinical situations, assessment of safety and effectiveness of clinical trial interventions, and ultimately, health and well-being of autistic children and adults.

PI_NAMEs: HOLINGUE, CALLIOPE  (contact)

PROGRAM_OFFICER_NAME: KAU, ALICE S

PROJECT_TERMS: 3 year old;Abdominal Pain;Address;Adolescent;Adult;adult with autism spectrum disorder;Age;associated symptom;Autism Diagnosis;autism spectrum disorder;autistic;autistic children;Behavior;behavioral health;Behavioral Symptoms;Biometry;Caregivers;Characteristics;Child;Childhood;Chronic;Clinical;Clinical Data;cognitive disability;cognitive interview;common symptom;Communication difficulty;Communities;Community Networks;Constipation;Data;design;Development;Device or Instrument Development;Diagnosis;Diarrhea;Dietary Practices;Dimensions;Disabling;Distress;effectiveness clinical trial;effectiveness evaluation;Ensure;Epidemiology;Equipment and supply inventories;Ethnic Origin;Evaluation;experience;Exploratory/Developmental Grant;Face;Foundations;Functional disorder;Gastroenterology;Gastroesophageal reflux disease;gastrointestinal;Gastrointestinal Diseases;gastrointestinal sign;gastrointestinal symptom;Goals;Guidelines;Health;improved;Individual;individuals with autism spectrum disorder;Intellectual functioning disability;Intervention;Intervention Trial;Language;Link;Literature;Lived experience;Measurement;Measures;Mental Health;minimally verbal;Neuropsychology;non-verbal;novel;online community;Parents;Participant;Patient Recruitments;Patient Self-Report;Performance;Personal Satisfaction;Persons;physical conditioning;Population;Positioning Attribute;Psychometrics;Quality of life;Questionnaires;Race;recruit;Reporting;Research;Research Institute;research study;Resources;safety assessment;Sampling;sex;sound;Structure;Subgroup;Symptoms;Testing;time use;tool;tv watching;United States National Institutes of Health;Validation;Work

PROJECT_TITLE: Development and Psychometric Evaluation of Gastrointestinal Symptom Measures in Autistic Children and Adults

STUDY_SECTION: ASPB

STUDY_SECTION_NAME: Analytics and Statistics for Population Research Panel B Study Section[ASPB]


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric

PHR: PROJECT NARRATIVE While the cerebellar dentate is one of the most commonly reported brain regions affected in brain tissue (post- mortem) studies of autism, examination of the dentate in living autistic children has been extremely challenging using standard (“3T”) MRI methods. To overcome this problem, we propose a highly innovative approach, using high-field (“7T”) MRI combined with a novel acquisition method (“susceptibility-weighted imaging – SWI”) and technique (“quantitative susceptibility mapping – QSM”) to successfully image the dentate in autistic children. This approach has strong potential for providing impactful discoveries about the brain basis of autism and provide novel brain-based targets for improving diagnosis, planning, and treatment for autistic individuals.

PI_NAMEs: MOSTOFSKY, STEWART H (contact)

PROGRAM_OFFICER_NAME: GILOTTY, LISA

PROJECT_TERMS: Address;Adult;Affect;Age;Anatomy;Animal Model;Area;autism spectrum disorder;autistic;autistic children;Autopsy;Behavior;Biological Markers;Brain;brain based;Brain region;brain tissue;Cerebellar Cortex;Cerebellar Nuclei;Cerebellum;Cerebral cortex;Child;Cognitive;cognitive skill;cohort;Data;Dentate nucleus;design;Development;Diagnosis;Dorsal;Emotional;Foundations;Functional disorder;Functional Magnetic Resonance Imaging;Future;Goals;Heritability;high reward;high risk;Human;Image;imaging modality;Impairment;improved;in vivo;in vivo imaging;individuals with autism spectrum disorder;innovation;interest;Intervention;Investigation;Iron;Knowledge;Left;Magnetic Resonance Imaging;Maps;Measures;Methods;Morphologic artifacts;morphometry;MRI Scans;neural network;neuroregulation;novel;novel marker;Pattern;Play;Population;Predisposition;Prognosis;Property;Publishing;Reporting;Research;Resolution;Rest;Role;Scanning;Severities;sex;Signal Transduction;social;social communication;Social Interaction;Stereotyped Behavior;Structure;Structure/Function Nuclei;Techniques;Thalamic structure;therapeutic target;Time;Visualization

PROJECT_TITLE: Ultra high-field (7T) in-vivo imaging for detailed characterization of cerebellar dentate nucleus structure and function in children with autism

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Emergency Care;Health Services;Social Determinants of Health;Violence Against Women;Violence Research;Women's Health Research

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE The purpose of this study is to identify the facilitators of coordinated care allowing us to access the levers of change to create a reliable system of care coordination for survivors of intimate partner violence (IPV) that is feasible, viable and, importantly, acceptable to all stakeholders, including IPV survivors, hospital and community-based organization (CBO) staff. We will accomplish this goal by conducting 30 in-depth interviews with IPV survivors, hospital and CBO staff to characterize facilitators and levers of change resulting in a logic model of change informing intervention development for IPV coordinated care in the emergency department setting, and through six focus group discussions with the same key stakeholder groups, we will generate intervention themes, components, scope and sequence. In collaboration with a community advisory board, we will finalize the logic model of change and intervention design for IPV coordinated care, ready for roll out and testing in the intervention production phase of future work.

PI_NAMEs: EVANS, DABNEY P (contact)

PROGRAM_OFFICER_NAME: MAHOLMES, VALERIE

PROJECT_TERMS: Accident and Emergency department;Acute;Admission activity;Age;Behavioral;burnout;care coordination;care systems;Caring;Collaborations;Communities;community advisory board;community based care;community based participatory research;Community Networks;community organizations;Complex;Computerized Medical Record;Data;Dementia;Domestic Violence;Elderly;Emergency department visit;Enrollment;Ensure;evidence base;experience;Face;Family;Focus Groups;Friends;Future;Goals;Health care facility;health care settings;Health Services;high risk;Hospitalization;Hospitals;Individual;Injury;Interruption;Intervention;intervention mapping;Interview;intimate partner violence;Knowledge;Life;Location;Logic;Long-Term Care;Measures;Medical;meetings;Methods;Modeling;Observational Study;Outcome;Participant;Pathway interactions;Patients;Performance;Persons;Phase;point of care;poor health outcome;pressure;Procedures;Process;Production;programs;Provider;Research;Resources;Risk;Role;Safety;safety net;scale up;service delivery;service organization;Services;Shelter facility;Site;Social Work;Standardization;success;Survivors;Testing;theories;therapy design;therapy development;Training;Trauma;treatment as usual;violent relationship;Visit;Woman;Work;Workplace

PROJECT_TITLE: Identifying facilitators of coordinated care for survivors of intimate partner violence: Formative research towards intervention development

STUDY_SECTION: SIHH

STUDY_SECTION_NAME: Science of Implementation in Health and Healthcare Study Section[SIHH]


NIH_SPENDING_CATS: Clinical Research;Digestive Diseases;Infant Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn

ORG_CITY: NEW HAVEN

ORG_DEPT: PEDIATRICS

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative In the United States, about half a million infants are born prematurely, prior to 37 weeks gestation, annually. Extremely premature infants born before 28 weeks gestation with a birth weight <1000g are most susceptible to complications of preterm birth, including spontaneous intestinal perforation, where little is known about the pathogenesis of this disease, and there are no disease-specific therapies. The proposed research will elucidate how aberrant T-cell activation exacerbates epithelial cell damage in spontaneous intestinal perforation with the hope of providing avenues for future studies into therapeutic targets in at-risk neonates.

PI_NAMEs: OLALOYE, OLUWABUNMI  (contact)

PROGRAM_OFFICER_NAME: SASLOWSKY, DAVID E

PROJECT_TERMS: 37 weeks gestation;Address;Affect;antenatal;Antibiotics;Biometry;Birth;Birth Weight;Brain Injuries;career;Cell Communication;Cell Differentiation process;cell growth;cell injury;Cells;Cessation of life;Child;Clinical;Coculture Techniques;comparative;Complex;Complication;congenital anomaly;Cryopreservation;cytokine;Cytometry;Data;Dedications;Defect;Development;Diagnostic;differential expression;Disease;early detection biomarkers;Enteral Feeding;Epithelial Cells;Epithelium;Etiology;experience;experimental study;Exposure to;extreme prematurity;Extremely Low Birth Weight Infant;fetal;fetal immunity;Fetus;Formalin;Fostering;Foundations;Future;gastrointestinal;Gene Expression Profile;Generations;Genes;Growth;Human;human disease;Hypoxia;Image;Immune;Immune system;Immune System Diseases;Immunobiology;Immunologics;Immunology;immunoregulation;improved;in utero;Infant;Infection;Inflammatory;insight;Interferon Type II;Intestinal Diseases;intestinal epithelium;Intestinal Perforation;Intestines;Investigation;Location;medical schools;Memory;Mentors;Modeling;Morbidity - disease rate;mortality;Mucous Membrane;Muscle;Neonatal;neonatal immunity;neonatal outcome;neonate;nutrition;Operative Surgical Procedures;Organoids;Paraffin Embedding;Pathogenesis;Pathway Analysis;Pathway interactions;Patients;Physicians;Predisposition;Pregnancy;premature;Premature Birth;Premature Infant;Preventive;Production;Proliferating;Publishing;Regulatory Pathway;Research;Research Personnel;Research Training;Resolution;Risk;Role;Sampling;Scientist;Signal Transduction;single-cell RNA sequencing;skills;Small Intestines;Spontaneous intestinal perforation;Steroids;Stimulus;T cell infiltration;T memory cell;T-Cell Activation;T-Lymphocyte;Therapeutic;therapeutic target;tissue resident memory T cell;Tissue Sample;Tissues;Total Parenteral Nutrition;Training;transcriptome;transcriptomics;United States

PROJECT_TITLE: Epithelial-immune interactions in neonates with Spontaneous Intestinal Perforation

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


NIH_SPENDING_CATS: Clinical Research;Genetics;Human Genome;Prevention;Urologic Diseases

ORG_CITY: CLEVELAND

ORG_DEPT: GENETICS

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

PHR: Project Narrative Urinary Stone Disease (USD) is a widespread ailment with significant health and economic impacts worldwide. However, the mechanisms underlying the condition are still not fully understood, and effective prevention strategies are lacking. This career development grant proposes to address these issues by employing next-generation sequencing technology to systematically investigate both monogenic and polygenic genes comprehensively and develop an integrated mono-polygenic risk model to facilitate precision medicine interventions.

PI_NAMEs: WU, CHEN-HAN WILFRED (contact)

PROGRAM_OFFICER_NAME: RANKIN, TRACY L

PROJECT_TERMS: Abdominal colic;Accounting;Address;Adult;Advisory Committees;Affect;American;Applications Grants;Biometry;Calcium;career development;Career Mobility;Childhood;Chronic Kidney Failure;Clinical;Clinical Trials;cohort;Complex;cost;Development;Development Plans;Diet;Disease;Doctor of Philosophy;early onset;economic impact;environmental intervention;Environmental Risk Factor;Epidemiology;Ethnic Origin;Etiology;exome;exome sequencing;experience;Extramural Activities;Five-Year Plans;Future;gene interaction;Genes;Genetic;Genetic study;genetic variant;genome sequencing;genome wide association study;genome-wide;Goals;Grant;Grouping;Health;Heritability;High Prevalence;improved;Intervention;Literature;Medical Care Costs;medical schools;Medicine;Mentors;Mentorship;Modeling;Morbidity - disease rate;Nature;next generation sequencing;novel;Outcome;Pathogenesis;Pathogenicity;Patient Care;Patient Recruitments;patient stratification;Patients;Pharmacologic Substance;Physicians;Physiology;polygenic risk score;precision medicine;Prevalence;Prevention strategy;Radiation exposure;Recurrence;recurrence prevention;Reporting;Research;Research Personnel;Risk;Risk Factors;risk variant;Role;scaffold;Science;Scientist;Single Nucleotide Polymorphism;skills;Structure;symposium;Technology;Training;trait;treatment strategy;United States National Institutes of Health;Urinary Calculi;Urology;Variant;Vegetables;virulence gene;Water consumption;whole genome;Work

PROJECT_TITLE: A comprehensive approach to understanding the genetic causes of urinary stone disease: combining monogenic and polygenic analyses

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Heart Disease;Lung;Mental Health;Neurosciences;Orphan Drug;Pulmonary Hypertension;Rare Diseases

ORG_CITY: Nashville

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: VANDERBILT UNIVERSITY

PHR: PROJECT NARRATIVE There is no effective medical therapy that halt the progression of pulmonary arterial hypertension. We have recently developed novel serotonin 2B antagonists that prevent pulmonary arterial hypertension in preclinical animal models. We propose to identify lead compounds from our novel chemistry series, examine them for safety and toxicity, and determine their efficacy in our pulmonary arterial hypertension preclinical models.

PI_NAMEs: MERRYMAN, WILLIAM D (contact)

PROGRAM_OFFICER_NAME: SUTLIFF, ROY L

PROJECT_TERMS: ABCB1 gene;adverse outcome;Aggressive behavior;analog;Animal Model;antagonist;Arteries;Automobile Driving;Behavioral;Binding;Binding Proteins;Biological Assay;Blood Vessels;blood-brain barrier penetration;Bone Marrow;Bone Marrow Diseases;Brain;Cardiac;Cells;Central Nervous System;Cerebral endothelium;Cerebrospinal Fluid;Chemistry;Clinical;clinical translation;Cytochrome P450;Development;Disease;Drug Interactions;drug-like compound;efficacy evaluation;Ethers;experimental study;Exposure to;Fibroblasts;Fibrosis;G-Protein-Coupled Receptors;Genes;Genetic Models;Hepatic;high throughput screening;HTR2A gene;Human;human subject;human tissue;Hypoxia;In Vitro;in vitro testing;in vivo;Invaded;Ion Channel;Lead;Lung;Measures;Mediating;Medical;Mental Depression;Modeling;Molecular;Monitor;Mus;Muscle;Mutagenicity Tests;Mutation;Myocardial Infarction;nanomolar;novel;novel therapeutics;Obstruction;Oral Administration;Parents;Pathogenesis;Penetration;Permeability;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacologic;Pharmacology;Pharmacotherapy;physical model;Plasma;Plasma Proteins;Population;Positioning Attribute;Potassium Channel;pre-clinical;Pre-Clinical Model;pressure;prevent;Primates;programs;pulmonary arterial hypertension;Pulmonary artery structure;Pulmonary Vascular Resistance;radioligand;Rattus;receptor;release of sequestered calcium ion into cytoplasm;right ventricular failure;Right Ventricular Hypertrophy;Risk;Running;Safety;safety testing;scaffold;screening program;Series;Serotonin;serotonin receptor;Serotonin Receptor 5-HT2B;Sleep disturbances;Source;suicidal;Testing;Therapeutic;Time;Toxic effect;Toxicology;Transfection;Translations;Treatment Efficacy

PROJECT_TITLE: Systemically restricted 5-HT2B antagonists for pulmonary arterial hypertension

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-M (81)]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Infectious Diseases;Microbiome

PHR: PROJECT NARRATIVE The immense public health burden of Clostridioides difficile infection (CDI) requires a better understanding of how variation in the microbiome contributes to disease outcome. The proposed studies will characterize mechanisms of commensal microbiota deterrence during C. difficile colonization and identify microbiome signatures of susceptibility to antibiotic-induced CDI. The results of this work will lead to the development of precise microbiome therapeutics that could be used to prevent CDI and innovative surveillance strategies to predict CDI.

PI_NAMEs: FISHBEIN, SKYE REBECCA (contact)

PROGRAM_OFFICER_NAME: RANALLO, RYAN

PROJECT_TERMS: Advisory Committees;Affect;Anaerobic Bacteria;Animal Model;Antibiotic susceptibility;Antibiotic Therapy;Antibiotics;assault;Attenuated;Award;bacterial community;career;Clindamycin;Clinical;clinically relevant;Clostridium difficile;colonization resistance;commensal microbes;Communicable Diseases;Communities;cost;Development;diagnostic strategy;Dietary Fiber;Disease Outcome;dysbiosis;Elements;Family;Foundations;Funding;gastrointestinal epithelium;genome sequencing;Gnotobiotic;Goals;gut inflammation;gut microbiome;Health Care Costs;health care settings;Healthcare;host microbiome;Human;Human Microbiome;human microbiota;humanized mouse;in vivo;Infection;Inflammation;innovation;Institution;Investigation;Leadership;Mediating;Mentors;Mentorship;Metabolic;Metabolic Pathway;Metabolism;Metagenomics;Methods;microbial;microbial community;microbiome;microbiome alteration;microbiome components;microbiome composition;microbiome signature;microbiome therapeutics;microbiota;Modeling;Morbidity - disease rate;mortality;mouse model;Multiomic Data;novel;novel therapeutic intervention;Outcome;pathogen;Pathogenesis;Pathogenicity;patient population;Patients;Plants;Play;Polysaccharides;prebiotics;Predisposition;prevent;Production;programs;Proliferating;Public Health;Research;resident commensals;Risk Factors;Role;Running;Severities;Severity of illness;skills;Source;Statistical Models;Structure;support network;surveillance strategy;symposium;synergism;Taxonomy;tool;Toxin;Training;transmission process;Universities;Variant;Virulence;Volatile Fatty Acids;whole genome;Work

PROJECT_TITLE: Identifying sources of variation in microbiome-pathogen dynamics during Clostridioides difficile colonization

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases B Research Study Section[MID-B]


NIH_SPENDING_CATS: Autoimmune Disease;Cardiovascular;Clinical Research;Heart Disease;Lupus

ORG_CITY: AUGUSTA

ORG_NAME: AUGUSTA UNIVERSITY

PHR: PROJECT NARRATIVE (PUBLIC HEALTH RELEVANCE STATEMENT) Patients with systemic lupus erythematosus (SLE, commonly called lupus), a devastating autoimmune disease that preferentially targets African Americans and women of childbearing age, are at high risk for cardiovascular disease due to accelerated atherosclerosis. The proposed project will define mechanisms whereby fat that surrounds the blood vessels contributes to lupus-associated vascular disease. Furthermore, this proposal may lead to new therapeutic strategies directed against cardiovascular disease in patients with lupus.

PI_NAMEs: SHI, HONG  (contact)

PROGRAM_OFFICER_NAME: MANCINI, MARIE

PROJECT_TERMS: Acceleration;Adipocytes;Adipose tissue;African American population;African Women;Age;aged;Aorta;Atherosclerosis;Atlases;Autoimmune Diseases;Bioinformatics;Biology;Blood Vessels;Body mass index;calcification;Cardiovascular Diseases;cardiovascular disorder risk;career;career development;Caring;Cause of Death;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Separation;Cells;Chest;Clinical;Cluster Analysis;Coculture Techniques;cytokine;Data;Dedications;density;Development Plans;Differentiation Antigens;Disease;endothelial dysfunction;Endothelium;Exhibits;Fatty acid glycerol esters;Female;Female of child bearing age;Flow Cytometry;Functional disorder;Funding;Future;Gene Expression Profile;Genomics;Goals;high risk;Hyperplasia;immune cell infiltrate;Immunoglobulin G;Immunology;Impairment;improved;in vivo;Incubated;Inflammation;Inflammatory;inflammatory marker;Inflammatory Response;Injury;insight;Interferon Type II;Knowledge;Laboratory Research;Leucocytic infiltrate;Lupus;lupus prone mice;Mentors;Molecular;mouse model;Mus;Myography;neointima formation;neutralizing antibody;novel;novel therapeutic intervention;paracrine;Pathogenesis;Pathogenicity;Pathway interactions;Patients;pharmacologic;Phenotype;Physicians;Play;professor;programs;Protocols documentation;public health relevance;radiological imaging;Relaxation;Research;Research Methodology;Research Personnel;Rheumatology;Risk Factors;Role;Scientist;Shapes;single nucleus RNA-sequencing;Systemic Lupus Erythematosus;T cell therapy;T-Lymphocyte;Testing;Therapeutic Intervention;Thoracic aorta;Time;Tissue Harvesting;Tissue Transplantation;Training;transplant model;Transplantation;Tunica Adventitia;Universities;Vascular Diseases;vascular inflammation;Wild Type Mouse

PROJECT_TITLE: Perivascular adipose tissue in the pathogenesis of lupus vasculopathy

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: EAST LANSING

ORG_NAME: HENRY FORD HEALTH + MICHIGAN STATE UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE DNA double strand breaks (DSBs) pose critical threats to genomic integrity and stability. One critical protein that facilitates DNA DSB repair is the DNA damage response protein, MDC1. These studies will reveal a new model for how DSB repair is regulated by MDC1 which will provide critical insights into how genome integrity is maintained in human cells.

PI_NAMEs: HEYZA, JOSHUA  (contact)

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TERMS: Active Sites;Adaptor Signaling Protein;Affinity;Alleles;Award;Binding;Biochemical;Biological Assay;biophysical techniques;BRCA1 gene;Cell Cycle;Cells;ChIP-seq;Chromatin;Complex;Coupled;CRISPR screen;Data;Dedications;Development;Disease;DNA Damage;DNA damage checkpoint;DNA Double Strand Break;DNA lesion;DNA Repair;Double Strand Break Repair;Epigenetic Process;Eukaryotic Cell;Funding;Future;G2 Phase;Gamma-H2AX;Genetic Recombination;Genetic Transcription;Genome;genome integrity;Genome Stability;genome-wide;genomic locus;Grant;Health;Histones;homologous recombination;Human;imaging study;Immune System Diseases;innovation;insight;Lesion;Link;link protein;live cell imaging;Maintenance;Malignant Neoplasms;Mediating;Mediator;Mentors;Modeling;Molecular;molecular imaging;mutant;Mutation;Nervous System Disorder;Nonhomologous DNA End Joining;Nucleosomes;Outcomes Research;p53-binding protein 1;Pathway interactions;Phase;Phosphorylation;Post-Translational Protein Processing;Postdoctoral Fellow;postmitotic;Process;programs;Proteins;Recombinants;recruit;Regulation;repair function;repaired;Reporter;Research;response;RNA;Role;Series;single molecule;Site;Testing;Training;Transcript;Ubiquitination;Variant;Work

PROJECT_TITLE: Molecular regulation of double-strand break repair by MDC1

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 TWD-8 (KR)]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Colorectal Cancer;Digestive Diseases;Genetics;Human Genome

PHR: Project Narrative Targeting RNA polymerase I is a potentially effective therapeutic strategy for the treatment of many cancer types. This study investigates and identifies mechanisms of therapeutic resistance resulting from rewiring of protein translation. The alterations in translation and ribosome function will be determined to facilitate new therapeutic strategies to overcome this resistance.

PI_NAMEs: FAN, WENJUN  (contact)

PROGRAM_OFFICER_NAME: SCHMIDT, MICHAEL K

PROJECT_TERMS: Ablation;Accounting;Anabolism;Automobile Driving;Biogenesis;Biology;Bypass;cancer cell;Cancer cell line;cancer survival;cancer therapy;cancer type;career;Cell Survival;Cells;Chemicals;Compensation;CRISPR/Cas technology;Data;Defect;design;Development;DNA Polymerase I;Drug resistance;Endowment;Face;FRAP1 gene;Gene Modified;Genes;Genetic;genetic approach;genetic regulatory protein;Genetic Transcription;genome-wide;Goals;Growth;HCT116 Cells;Human;in vivo;inhibitor;Knock-out;Knowledge;Large Intestine Carcinoma;Malignant Epithelial Cell;Malignant Neoplasms;Mass Spectrum Analysis;Mediating;Mentors;Messenger RNA;Modeling;mTOR inhibition;Mus;novel therapeutic intervention;Organoids;Pathway interactions;pharmacologic;polysome profiling;pre-clinical;preclinical study;Process;programs;Protein Biosynthesis;Protein Inhibition;Proteins;Proteomics;Research;Resistance;resistance mechanism;Resources;response;Ribosomal RNA;ribosome profiling;Ribosomes;RNA Polymerase I;RPS3 gene;skills;small molecule;Stress;Testing;Therapeutic;therapeutically effective;therapy resistant;tool;TP53 gene;transcriptome;Translating;translational approach;translational progress;Translations;translatome;treatment response;treatment strategy;tumor;tumor progression;whole genome

PROJECT_TITLE: Translation Rewiring Underlines Drug Resistance to Lethal Targeted Ribosome Biogenesis Therapeutics in Cancer

STUDY_SECTION_NAME: Transition to Independence Study Section (I)[NCI-I]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Hematology;Mental Health;Physical Injury - Accidents and Adverse Effects;Pregnancy;Prevention;Rare Diseases;Sickle Cell Disease;Social Determinants of Health;Violence Against Women;Violence Research;Women's Health Research

ORG_CITY: BOSTON

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: PROJECT NARRATIVE The proposed study addresses a key NHLBI priority, improving the quality of life for people with sickle cell disease globally. To do so, the study will employ mixed-methods, pilot trial to implement and test an integrated sickle cell screening and violence prevention intervention in the Sickle Cell Belt in Central India. The overarching goal of this study is to develop and test strategies to improve the safety of pregnancy and childbirth in stigmatized populations, particularly those with sickle cell disease or sickle cell trait.

PI_NAMEs: HALIM, NAFISA  (contact)

PROGRAM_OFFICER_NAME: FRANK, DANIEL J

PROJECT_TERMS: Address;African;antenatal;antenatal care;Anxiety;anxiety symptoms;arm;Asian;Award;Birth;Boston;career;catalyst;Child;Child Health;Childbirth;Clinic;Clinical;community advisory board;Consent;Consolidated Framework for Implementation Research;Counseling;Couples;Data;depressive symptoms;Development;Diagnosis;Disclosure;Distress;efficacy outcomes;Electrophoresis;Enrollment;Ethics;Evaluation;experience;Feedback;Goals;Government;Health;Hemoglobin;HIV;Home;implementation outcomes;implementation science;improved;India;Infrastructure;Intervention;Interview;intimate partner violence;Joints;Learning;literacy;Low Birth Weight Infant;male;Manuals;Medical;member;Mental Depression;mental health counseling;Mental health promotion;Mentored Research Scientist Development Award;Mentors;Methods;Mothers;Municipalities;National Heart, Lung, and Blood Institute;National Institute of Child Health and Human Development;Nurse Midwives;Nurses;Nurses' Aides;Outcome;Participant;Persons;Phase;pilot test;pilot trial;Population;Populations at Risk;Pregnancy;pregnant;Pregnant Women;prevent;Prevention program;preventive intervention;Process;psychosocial;Quality of life;Randomized;Reaction;recruit;Reporting;Research;Resources;Risk;Safety;Scientist;screening;Shapes;Sickle Cell;Sickle Cell Anemia;Sickle Cell Trait;Sickle Hemoglobin;Site;skill acquisition;skills;Solubility;Stigmatization;Structure;success;Surveys;Test Result;Testing;theories;therapy development;Training;Trauma;unborn child;Universities;violence prevention;Visit;Woman

PROJECT_TITLE: Pilot-testing and Implementation of an Integrated Sickle-cell Screening and Violence Prevention Program in Antenatal Care Settings in India (PIVOT)

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS (OA)]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Networking and Information Technology R&D (NITRD);Primary Health Care;Rural Health;Telehealth

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE Nearly 20% of the more than 30 million Americans with type 2 diabetes face geographic or transportation barriers to diabetes specialty care. Telemedicine has the potential to help more patients access this care, but evidence suggests telemedicine is less effective for adults with type 2 diabetes which is complex, including those who use multiple daily injections of insulin and have multiple comorbid conditions. The objective of this project is to develop an intervention to deliver high-quality virtual diabetes specialty care to adults with complex type 2 diabetes, thereby improving effectiveness of care for patients who rely on telemedicine.

PI_NAMEs: ZUPA, MARGARET  (contact)

PROGRAM_OFFICER_NAME: BURCH, HENRY B

PROJECT_TERMS: Address;Adult;American;Benchmarking;Blindness;Blood Glucose;career;career development;Caring;Chronic;Clinical;Clinical Trials Design;cohort;Communication;comorbidity;Complex;Complications of Diabetes Mellitus;Data;data sharing;design;Development;Diabetes Mellitus;diabetes self-management;Disease;Disparity;Drug Prescriptions;Education;Effectiveness;effectiveness-implementation randomized trial;effectiveness/implementation hybrid;effectiveness/implementation trial;Elements;Endocrine;Endocrinologist;Endocrinology;Evaluation;experience;Face;Frequencies;Future;future implementation;Geography;Glucose;Glycosylated hemoglobin A;Goals;Guidelines;health care delivery;Health Services;Health Services Accessibility;Health Services Research;Health system;high risk;Home;Immunization;implementation science;Improve Access;improved;improved outcome;Injections;Insulin;Integrated Health Care Systems;Intervention;Interview;K-Series Research Career Programs;Kidney Diseases;Knowledge;Link;medical specialties;Mentored Patient-Oriented Research Career Development Award;Mentors;Methods;Modality;Modeling;mortality;multidisciplinary;National Institute of Diabetes and Digestive and Kidney Diseases;Non-Insulin-Dependent Diabetes Mellitus;novel strategies;Outcome;Pathway interactions;Patient Care;patient oriented;Patient-Focused Outcomes;Patients;Patterns of Care;Persons;Pharmaceutical Preparations;pilot trial;Pragmatic clinical trial;pragmatic intervention;Primary Care;Proteins;Protocols documentation;Provider;Quality of Care;Randomized;randomized trial;remote monitoring;Reporting;Research;research and development;Research Personnel;Retina;Risk;rural area;satisfaction;skills;Specialist;Structure;Telemedicine;Testing;therapy design;Training;Translating;Transportation;Urine;virtual;virtual healthcare;Visit;Work

PROJECT_TITLE: Increasing Reach of Effective Virtual Specialty Care for Adults with Diabetes Through Tailored Modalities

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-2 (O1)]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Clinical Research;Gene Therapy;Genetics;Nanotechnology;Neuroblastoma;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Precision Medicine;Rare Diseases

ORG_NAME: DANA-FARBER CANCER INST

PHR: PROJECT NARRATIVE Nanoparticle-based therapies have many potential advantages for treating cancer, but there are currently no clinical biomarkers to predict which patients are most likely to benefit from nanotherapies. This proposal seeks to validate the solute carrier SLC46A3 as a regulator of phospholipid metabolism in cancer cells and the first predictive biomarker for liposomal nanoparticle delivery.

PI_NAMEs: STRAEHLA, JOELLE PAYNE (contact)

PROGRAM_OFFICER_NAME: LIM, SUSAN E

PROJECT_TERMS: Acceleration;Address;Advisory Committees;Anabolism;anti-cancer research;Antineoplastic Agents;Area;Award;Biological Markers;Biological Models;Boston;cancer biomarkers;cancer cell;Cancer cell line;Cancer Patient;cancer therapy;career;Cell Line;Cells;Characteristics;Chemicals;Childhood;Clinic;clinical biomarkers;Clinical stratification;Clinical Trials;Dana-Farber Cancer Institute;Data;Dependence;design;Doxorubicin;Drug Delivery Systems;Education;Engineering;Environment;experience;Fatty Acids;FDA approved;Formulation;functional genomics;Future;Genetic;Genotype;Goals;Homeostasis;Image;Impairment;improved;In Vitro;in vivo;Injections;insight;interest;International;Investigation;irinotecan;Knock-out;Knowledge;Leadership;Link;lipid metabolism;lipid nanoparticle;Lipids;liposomal delivery;liposomal formulation;Liposomes;Malignant Childhood Neoplasm;Malignant Neoplasms;Massachusetts;Mentors;Mentorship;Metabolism;Modeling;nano;nanocarrier;nanomaterials;nanomedicine;nanoparticle;nanoparticle delivery;nanoparticle drug;nanotherapeutic;nanotherapy;Nature;neoplastic cell;Neuroblastoma;Oncology;Patients;Pediatric Hospitals;Pediatric Oncologist;Pediatric Oncology;Pharmaceutical Preparations;Phenotype;Phospholipid Ethers;Phospholipid Metabolism;Phospholipids;Physicians;Plasmalogens;Play;Positioning Attribute;pre-clinical;predictive marker;programs;Research;Research Personnel;response;Role;Scientist;skills;solute;specific biomarkers;Specificity;Starvation;Stratification;Structure;Systems Biology;targeted agent;Technology;Testing;Therapeutic;therapeutic nanoparticles;Tissues;trafficking;Training;Translations;Transport Process;Treatment Efficacy;tumor;tumor metabolism;uptake;Work

PROJECT_TITLE: Investigating SLC46A3 as a negative regulator of nanoparticle drug delivery

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Prevention;Social Determinants of Health

ORG_CITY: LITTLE ROCK

ORG_NAME: UNIV OF ARKANSAS FOR MED SCIS

ORG_STATE: AR

PHR: PROJECT NARRATIVE  Jail correctional officers experience high stress exposure, adverse mental health outcomes, and health disparities which necessitates addressing CO stress management in jail settings. Using implementation science methods, this study will develop an implementation strategy package to deliver a stress management intervention in the jail. Subsequently, we will conduct a pilot hybrid type II effectiveness-implementation trial of the intervention and the implementation strategies measuring acceptability, appropriateness, feasibility, and fidelity.

PI_NAMEs: GORVINE, MARGARET  (contact)

PROGRAM_OFFICER_NAME: BAUMGARTNER, JENNIFER NICOLE

PROJECT_TERMS: Address;Administrator;Admission activity;Affect;African American population;Anxiety;Arkansas;Biometry;burden of chronic illness;burnout;Chronic;Clinical Trials;cohort;Collaborations;college;community building;community engaged research;Competence;Consolidated Framework for Implementation Research;COVID-19;Criminal Justice;Crowding;Data;Dose;Educational Intervention;Effectiveness;effectiveness measure;effectiveness testing;effectiveness/implementation trial;Environment;evidence base;Evidence based practice;experience;Feeling suicidal;first responder;formative assessment;Funding;General Population;Goals;Health;health assessment;Health behavior;Health behavior and outcomes;health disparity;Health education;health outcome disparity;high risk;Home;Hour;Hybrids;implementation evaluation;implementation measures;implementation outcomes;implementation research;implementation science;implementation strategy;Imprisonment;improved;improvement on sleep;innovation;instructor;Integrative Medicine;Intervention;intervention delivery;Intervention Studies;Intervention Trial;Interview;Jail;K-Series Research Career Programs;Learning;Life Expectancy;Measures;Medical;Mental Depression;Mental Health;Mentors;Methods;Military Personnel;Mind-Body Intervention;mind/body;mindfulness;Mindfulness Training;Modification;National Center for Complementary and Integrative Health;negative affect;novel;Nurses;Occupations;Outcome;Participant;perceived stress;pilot test;Police;Population;Post-Traumatic Stress Disorders;Postdoctoral Fellow;primary outcome;Prisons;Process;Public Health;racial health disparity;Relaxation;Reporting;Research;Research Methodology;Research Personnel;resilience;Resources;Risk;Safety;Science;Scientist;Security;Services;Site;skills;Sleep disturbances;sleep quality;Stress;stress management;stress reactivity;Testing;Training;Translating;United States;Universities;uptake;Violence;Work;Workplace

PROJECT_TITLE: Harnessing implementation science to study stress management for correctional officers in jail settings

STUDY_SECTION_NAME: Special Emphasis Panel[ZAT1 AM (01)]