ORG_CITY: FORT COLLINS

ORG_NAME: COLORADO STATE UNIVERSITY

ORG_STATE: CO

PHR: Project Narrative The SARS-Co-V2 pandemic has made it clear that we need new, rapid, and adaptable methods to create and manufacture new vaccines for emerging infectious diseases. While mRNA vaccines have been produced with unprecedented speed and high levels of efficacy, they are challenging to manufacture and need to be kept frozen, preventing their rapid distribution across the globe. As future epidemics caused by new viruses are expected to occur with increasing frequency due to global socio-economic, environmental, and ecological trends, we are pursuing the development of a new DNA vaccine system that would be easier to deploy on a global scale than mRNA vaccines because they could be conserved at ambient temperature and would be easier to manufacture.

PI_NAMEs: PECCOUD, JEAN M (contact)

PROGRAM_OFFICER_NAME: GORDON, JENNIFER L

PROJECT_TERMS: 2019-nCoV;Address;Animals;Antigens;Architecture;Bacteriophage T7;Biological Assay;Biology;Biomanufacturing;Cell Culture Techniques;Cell Nucleus;Cell Survival;Cells;Clinical;Code;Cold Chains;Complex;Coronavirus;Country;COVID-19;COVID-19 pandemic;COVID-19 vaccine;Cytoplasm;Data;design;design and construction;design,build,test;Development;DNA;DNA amplification;DNA cassette;DNA delivery;DNA Vaccines;dosage;Emergency Situation;Emerging Communicable Diseases;Ensure;Enzymes;Event;experimental study;expression vector;feasibility testing;Feedback;Flow Cytometry;Fluorescent in Situ Hybridization;Freezing;Frequencies;Future;future epidemic;Gene Amplification;Gene Expression;Generations;Genes;Genetic;Genetic Transcription;Genomics;Healthcare Systems;Hour;Human;Immune response;immunogenic;immunogenicity;improved;Incentives;Industry;Inferior;Infrastructure;innovation;interest;Investigation;Learning;Life;Location;manufacture;manufacturing facility;manufacturing process;Measures;Messenger RNA;Methods;mRNA capping;next generation;novel;novel vaccines;Nucleic Acid Vaccines;plasmid DNA;Plasmids;preservation;prevent;Process;Production;Program Development;promoter;Property;Research Personnel;RNA;RNA amplification;RNA vaccine;Safety;scaffold;single molecule;socioeconomics;Speed;Structure;success;synthetic biology;System;T7 RNA polymerase;Technology;Temperature;Testing;Time;Transcription Initiation;Transfection;Translations;trend;vaccine access;vaccine candidate;Vaccine Design;vaccine development;vaccine platform;Vaccines;Variant;vector;vector vaccine;Viral Genes;Virus

PROJECT_TITLE: Leveraging cytoplasmic transcription to develop self-amplifying DNA vaccines

STUDY_SECTION: GDD

STUDY_SECTION_NAME: Gene and Drug Delivery Systems Study Section[GDD]


ADMINISTERING_IC: HL

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Hematology;Rare Diseases;Sickle Cell Disease

ORG_CITY: LOS ANGELES

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

ORG_STATE: CA

PHR: Project Narrative While blood transfusions have been life-saving for many patients with sickle cell disease, the immune response to red blood cells can be detrimental. This project investigates why patients with sickle cell disease are more likely to make these harmful immune responses. Identifying factors that lead to increased immune responses could allow identification of at-risk patients prior to transfusion and allow for personalized protocols to improve transfusion safety.

PI_NAMEs: GIBB, DAVID R (contact)

PROGRAM_OFFICER_NAME: WELNIAK, LISBETH A

PROJECT_TERMS: Address;Allogenic;Alloimmunization;Antibodies;Antigens;antiviral immunity;Autoantibodies;Autoantibody binding;Autoimmunity;Blocking Antibodies;Blood;Blood Transfusion;Cell Culture Techniques;Cells;Coculture Techniques;cytokine;Cytokine Activation;Data;Disease;Erythrocyte Transfusion;Erythrocytes;Erythrophagocytosis;Evaluation;Event;Exposure to;Flow Cytometry;Frequencies;Genes;genetic signature;Goals;Human;Immune response;improved;Incidence;Inflammation;Inflammatory;insight;Interferon alpha;Interferons;Intervention;Investigation;Isoantibodies;Kinetics;Leukocytes;Life;Ligands;Liver;Macrophage;Measures;Mediating;Mediator;Modeling;mouse model;Mus;Nucleic Acid Binding;Nucleic Acids;Pathway interactions;Patients;Phagocytosis;Play;Population;pre-clinical;Pre-Clinical Model;Process;Production;Protocols documentation;receptor;receptor binding;Reporter;Reporting;response;Reticulocyte count;Reticulocytes;Reticulocytosis;Risk;risk stratification;Role;Safety;Serum;Sickle Cell Anemia;Signal Pathway;Signal Transduction;Spleen;Testing;Transfusion;Virus Diseases

PROJECT_TITLE: Autoantibody-induced type 1 interferons and RBC alloimmunization in sickle cell disease

STUDY_SECTION: HTBT

STUDY_SECTION_NAME: Hemostasis, Thrombosis, Blood Cells and Transfusion Study Section[HTBT]


ADMINISTERING_IC: LM

ED_INST_TYPE: UNIVERSITY-WIDE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Coronaviruses;Coronaviruses Diagnostics and Prognostics;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Health Services;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Prevention

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative This proposed research is relevant to public health because we aim to improve upon predictive analytic tools that inform clinical decision-making by developing frameworks to address dataset shift, a cause of model deterioration in dynamic settings, a critical step to accurately identify high risk patients who may benefit from earlier interventions. This proposal will evaluate extent and mechanisms of dataset shift during the emergence of the COVID-19 pandemic in an existing EHR-based risk prediction model, understand how rapid shift in model performance impacts case-management, and assess competing methods of model revision and retraining that address dataset shift and optimize predictive accuracy over time. Findings from this work are relevant to the NIH’s mission by generating fundamental knowledge to inform clinicians, researchers, and policy makers about effective approaches to improve the reliability of predictive analytic tools, thereby allowing better risk-adjusted targeting of evidence-based outpatient interventions that decrease likelihood of future hospitalization.

PI_NAMEs: KOLLA, LIKHITHA  (contact)

PROGRAM_OFFICER_NAME: YOON, SUNG SUG

PROJECT_TERMS: Accident and Emergency department;Address;Advanced Malignant Neoplasm;Algorithms;analytical tool;beneficiary;Biometry;care delivery;career development;Caring;Case Management;Cessation of life;Characteristics;Clinical;clinical application;clinical decision-making;clinical predictive model;Code;Collection;Compensation;COVID-19;COVID-19 pandemic;Data;Data Set;Data Sources;demographics;design;Deterioration;Development;Development Plans;doctoral student;Early Intervention;Electronic Health Record;Environment;evidence base;Future;Generations;Guidelines;Health;health care disparity;health care service utilization;health care settings;health service use;Health system;Healthcare;high risk;Hospital Costs;Hospitalization;Impairment;improved;Incentives;innovation;Inpatients;Institution;Interruption;Intervention;Knowledge;Laboratories;Machine Learning;Maintenance;Methods;Mission;model design;model development;Modeling;mortality risk;Needs Assessment;Onset of illness;operation;Outcome;outpatient programs;Outpatients;pandemic disease;pandemic impact;Patient Care;Patients;Performance;Physicians;Play;Policies;Policy Maker;Population;prediction algorithm;Predictive Analytics;predictive modeling;predictive tools;prevent;Primary Care;Process;provider behavior;Public Health;Qualifying;Quarantine;Refit;Reporting;Research;research and development;Research Personnel;Resource Allocation;Resources;Risk Adjustment;risk prediction;risk prediction model;Role;Scientist;Sepsis;Series;System;Testing;Time;tool;Training;training data;Triage;United States National Institutes of Health;Validation;Veterans Health Administration;Work

PROJECT_TITLE: Addressing Algorithmic Unreliability and Dataset Shift in EHR-based Risk Prediction Models

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F16-L(20)L]


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: STANFORD

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: Narrative summary Islet development in pigs and humans have remarkable similarities, including molecular, genetic, cellular, physiological resemblances not observed in more commonly investigated animal models like mice. Here we propose developmental studies of islet gene regulation and functional maturation, and genome editing in pigs, that should reveal conserved mechanisms underlying islet formation and function, and generate new genetic models of human diabetes mellitus.

PI_NAMEs: BERGER, TRISH ;KIM, SEUNG K (contact)

PROGRAM_OFFICER_NAME: ZAGHLOUL, NORANN

PROJECT_TERMS: access restrictions;Address;Adolescent;Adult;age related;Alleles;Alpha Cell;Animal Model;Architecture;Beta Cell;Biology;Cell Line;Cells;Chromatin;Collaborations;cost;CRISPR/Cas technology;D Cells;Development;Developmental Biology;Developmental Gene;developmental genetics;Diabetes Mellitus;diabetes mellitus genetics;Disease;Endocrine;endocrine pancreas development;Epigenetic Process;Estradiol;Estrogens;Family suidae;fetal;fetus cell;flexibility;Flow Cytometry;Gene Expression;Gene Expression Regulation;Generations;Genes;Genetic;genetic architecture;Genetic Diseases;Genetic Models;Genetic Transcription;genome editing;genome-wide;Genomics;Glucagon;Gonadal Hormones;Gonadal Steroid Hormones;Health;Heterozygote;Histones;Human;human disease;human model;improved;in vivo;individual variation;Insulin;interest;Investigation;islet;Islet Cell;Islets of Langerhans;Link;Maps;Measures;Metabolic;Methods;Modeling;Molecular;Mus;mutant;Mutation;Neonatal;Organ;Output;Pancreas;pancreas development;pancreatic islet function;Pathogenesis;Pathologic;Phenotype;Physiological;postnatal;Puberty;Regulation;Reproductive Biology;Research;Research Personnel;Rodent;Rodent Model;Role;Signal Pathway;Signal Transduction;stem cells;System;Testing;Therapeutic;Tissues;transcription factor;transcriptome;Work

PROJECT_TITLE: Genetic and physiologic regulation of pig islet development and function


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: BALTIMORE

ORG_DEPT: PSYCHIATRY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Narrative: LRRK2 (Leucine Rich Repeat Kinase 2) protein is one of the major risk factors for Parkinson’s disease (PD). We recently discovered that LRRK2 interacts with NLRP1 and NLRP3 proteins, which are key mediators of immunity, suggesting a role for specific pathways of cellular innate immunity, inflammation and neurodegeneration in pathogenesis of PD. We will investigate these pathways, which may provide novel targets for development of disease-modifying therapeutic strategies.

PI_NAMEs: ROSS, CHRISTOPHER A;SMITH, WANLI W (contact)

PROGRAM_OFFICER_NAME: SULLIVAN, LUIS FLANAGAN

PROJECT_TERMS: Affect;Animal Model;Biological;Biological Assay;Blood;Brain;brain tissue;Cell Death;Cells;Cerebrospinal Fluid;Chronic Disease;Code;Collaborations;Crohn's disease;cytokine;design;Development;Disease;Disease Progression;dopaminergic neuron;Dose;Encephalitis;gain of function;Genes;Genetic;genetic approach;glial activation;GTP Binding;Guanosine Triphosphate Phosphohydrolases;Human;human induced pluripotent stem cells;IL18 gene;Immune;Immune System Diseases;Immunity;In Vitro;in vivo;Induction of Apoptosis;Infection;Inflammasome;Inflammation;Inflammation Mediators;Inflammatory;Inflammatory Response;Injury;innate immune function;insight;Interleukin-1 beta;Intervention;knock-down;Knock-in;Knock-in Mouse;Knock-out;Knockout Mice;Leprosy;Link;Lipopolysaccharides;LRRK2 gene;Maps;Mediating;Mediator;Microglia;Molecular;Mus;mutant;Mutation;Natural Immunity;Nerve Degeneration;Nervous System Disorder;Neurodegenerative Disorders;Neuroglia;neuroinflammation;Neuronal Injury;Neurons;novel;Onset of illness;overexpression;Parkinson Disease;Pathogenesis;Pathogenicity;Pathology;Pathway interactions;Patients;Pharmaceutical Preparations;pharmacologic;Phosphotransferases;Pilot Projects;Point Mutation;potential biomarker;Production;Property;protein expression;Protein Family;Proteins;receptor;Risk;Risk Factors;Role;sensor;Signal Transduction;Small Interfering RNA;sporadic Parkinson's Disease;targeted biomarker;Testing;Therapeutic;tool;Toxic effect;Transgenic Organisms

PROJECT_TITLE: LRRK2 and inflammasome pathway in Parkinson's disease

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD]


ORG_CITY: NEW YORK

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: NARRATIVE Eighty-five percent (85%) of cardiovascular disease (CVD) deaths occur due to either myocardial infarction (MI) or stroke, platelet-driven events. Antiplatelet therapy is not commonly prescribed to prevent a first MI or stroke as the cardioprotective benefits are offset by major bleeding risk. This study will investigate a previously unexplored platelet candidate to ascertain how it regulates functional responses, to ultimately provide a rationale for the development of a new therapeutic class to dampen the inflammatory and prothrombotic actions of platelets.

PI_NAMEs: BARRETT, TESSA  (contact)

PROGRAM_OFFICER_NAME: GOLDBERG, ILANA GRACE

PROJECT_TERMS: Acceleration;adaptive immunity;Affect;Affinity Chromatography;affinity labeling;Agonist;Area;Arterial Fatty Streak;Arteries;arteriole;atherogenesis;Atherosclerosis;atherothrombosis;Binding;Binding Proteins;Biological Response Modifiers;Blood Platelets;Bone Marrow;cardioprotection;Cardiovascular Diseases;cardiovascular disorder prevention;Cardiovascular system;Cell Communication;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Cessation of life;Chronic;Clinical;cohort;Cytometry;Data;Development;Disease;Event;follow-up;Foundations;Genes;Hemorrhage;Hemostatic Agents;Hemostatic function;Human;IL6 gene;in vivo;indexing;Individual;Inflammation;Inflammatory;Innate Immune Response;insight;Integrins;Knockout Mice;Knowledge;Leukocytes;Macrophage;Mass Spectrum Analysis;Mediating;Mediator;Membrane Microdomains;Mesentery;Microscopy;Modeling;Molecular;monocyte;mouse model;Mus;Myocardial Infarction;new therapeutic target;novel;novel therapeutics;Outcome;Pathogenesis;Pathway interactions;Patients;Pattern;Phenocopy;Phenotype;Physiological;Platelet Activation;Platelet aggregation;Play;prevent;Primary Prevention;Protein Binding Domain;Proteins;receptor;recruit;Resolution;response;Rest;Risk;Role;shear stress;Signal Transduction;Signaling Protein;Stenosis;Stroke;systemic inflammatory response;Testing;Therapeutic;Thrombosis;Thrombus;Time;transcriptome sequencing;transcriptomics;Transplantation;vascular injury

PROJECT_TITLE: CD37 as a Regulator of Platelet Patho(Physiological) Responses


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cardiovascular;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Disability Research;Nutrition;Obesity;Pain Research;Patient Safety;Physical Activity;Physical Rehabilitation;Prevention;Rehabilitation

ORG_CITY: COLUMBIA

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

ORG_STATE: SC

PHR: Total knee replacement utilization continues to increase across all age groups and is placing substantial burden on the economy. To maximize the value of the costly surgery, it is necessary to identify effective and scalable strategies to improve weight management and maintain function in this aging population following knee replacement. This project examines if a weight loss program designed for patients after knee replacement improves weight loss, physical activity, pain, and function, as well as if the program is cost effective.

PI_NAMEs: PELLEGRINI, CHRISTINE ANN (contact)

PROGRAM_OFFICER_NAME: NELLISSERY, MAGGIE JACOB

PROJECT_TERMS: 2 arm randomized control trial;Adherence;Adult;Aerobic;Age;age group;aging population;Alzheimer's Disease;Behavioral;Body Weight;Body Weight Changes;Body Weight decreased;Calories;Cardiovascular Diseases;Cardiovascular system;Cessation of life;Chronic Disease;comparison control;Competence;Control Groups;cost;Cost Analysis;cost effective;cost effectiveness;Data;Data Collection;Dementia;design;Diet;disability;disability risk;Disease;Effectiveness;effectiveness evaluation;Energy Intake;experience;Fright;functional disability;functional improvement;functional outcomes;Goals;health care service utilization;Health Educators;Health Promotion;health related quality of life;improved;Injury;Insurance;Intervention;Knee Osteoarthritis;knee replacement arthroplasty;Link;Maintenance;Measures;Mediator;Modeling;Monitor;mortality;mortality risk;Obesity;older adult;Operative Surgical Procedures;Orthopedics;Outcome;Outcome Study;Overweight;Pain;Participant;patient oriented;Patient Preferences;Patient Self-Report;Patient-Focused Outcomes;Patients;Persons;Phase;Physical activity;Physical Function;physical inactivity;physical therapist;Pilot Projects;primary outcome;Productivity;programs;Psyche structure;psychosocial;Quality-Adjusted Life Years;Randomized;Reporting;Resistance;Risk;Risk Reduction;secondary outcome;Self Direction;Self Efficacy;Self Management;Surgeon;Telephone;telephone coaching;Testing;Training;Walking;Weight;Weight Gain;weight loss intervention;weight loss program;Weight maintenance regimen;Weights and Measures;Work

PROJECT_TITLE: Physical Activity and Weight Loss to Improve Function and Pain after Total Knee Replacement

STUDY_SECTION: BMHO

STUDY_SECTION_NAME: Biobehavioral Medicine and Health Outcomes Study Section[BMHO]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Hematology;Pediatric

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: NARRATIVE  Research in pediatric benign hematology plays an important role in advancing the diagnosis and treatment of inherited disorders including sickle cell disease and the thalassemias, hemophilia and thrombophilia, bone marrow failure syndromes, and benign vasculogenesis disorders. Improved therapy and cure for inherited and acquired pediatric blood diseases will improve the quality of life of affected individuals, reduce hospital admissions, and minimize in-hospital acquired clotting complications. The study of benign pediatric hematology disorders is very much underserved as recognized by the NIH and our training program has been a nationally recognized leader in attracting and fostering the development of talented trainees who become the future pediatric science and leaders, advancing our understanding of benign pediatric blood diseases and identifying novel treatments and cures.

PI_NAMEs: CHOU, STELLA T;PONCZ, MORTIMER  (contact)

PROGRAM_OFFICER_NAME: HILL-PRYOR, CRYSTAL DARLEANE-ROBIN

PROJECT_TERMS: Pediatric Hematology;Research Training;Training Programs

PROJECT_TITLE: Pediatric Hematology Research Training Program


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: MANHASSET

ORG_NAME: FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH

PHR: Project Narrative The immune system and nervous system work together to coordinate host responses to infection and injury. Inflammation is part of the innate immune response, but it is not known how the nervous system senses and transmits signals about inflammatory mediators. Using a novel technique to record from peripheral sensory neurons, we will determine how neurons encode and represent these important immune-related signals.

PI_NAMEs: CHANG, ERIC HAU-YUN (contact)

PROGRAM_OFFICER_NAME: NELSON, SHAKIRA M

PROJECT_TERMS: Afferent Neurons;Anatomy;Anti-Inflammatory Agents;Auditory;Biological Response Modifiers;Brain;Brain Stem;Calcium;Cells;Cholinergic Fibers;Code;Collection;Communication;Complex;Critical Pathways;cytokine;Disease;Endotoxins;experience;Genetic;Goals;Homeostasis;Image;Immune;Immune response;Immune signaling;Immune system;Immunity;Immunology;In Situ;in vivo imaging;Individual;Infection;Inflammation;Inflammation Mediators;Inflammatory;Injury;Innate Immune Response;Innate Immune System;insight;Interleukin-1 beta;Knowledge;Mediating;Modernization;Molecular;Monitor;Motor;Motor Pathways;Nervous System;neural;neuroimaging;Neuroimmune;neuromechanism;Neurons;neuroregulation;Neurosciences;neurotransmission;Nodose Ganglion;novel;Organ failure;Pathway interactions;Peripheral;Peripheral Nervous System;Population;Production;Reflex action;response;Scientist;Sensory;sensory neuroscience;Signal Transduction;Spleen;System;Techniques;TNF gene;tool;transmission process;Traumatic injury;Travel;Vagus nerve structure;Visual;Work

PROJECT_TITLE: Encoding of inflammatory mediators by vagal sensory neurons

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Back Pain;Behavioral and Social Science;Chronic Pain;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pain Research;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: SAN DIEGO

ORG_DEPT: MISCELLANEOUS

ORG_NAME: SAN DIEGO STATE UNIVERSITY

PHR: PROJECT NARRATIVE While physical activity (PA) has been widely accepted as an effective non-pharmacological pain management strategy, many Latinos with chronic spine pain (CSP) do not engage in PA, highlighting the need to investigate the multilevel factors that intersect to contribute to this disparity. The proposed study will apply an intersectional perspective informed by the socioecological model to examine multilevel factors that influence momentary PA to better understand determinants of PA participation among Latinos with CSP. The knowledge gained from this study will inform future development of culturally relevant and personalized digital health interventions that address real-time barriers to PA with the ultimate goal of alleviating PA health disparities in Latinos with CSP.

PI_NAMEs: DIONICIO, PATRICIA  (contact)

PROGRAM_OFFICER_NAME: HERREN, OLGA MARINA

PROJECT_TERMS: Accelerometer;adaptive intervention;Address;Adult;Affect;Behavior;Behavior Therapy;Belief;Chronic;chronic pain;chronic pain management;Clinical Trials;comorbidity;Data;Development;digital health;Disadvantaged;Discrimination;Disparity;Ecological momentary assessment;Elements;Emotions;Environment;Environmental Risk Factor;Event;experience;Facial Pain;Foundations;Future;Gender;Goals;health care availability;health determinants;health disparity;health outcome disparity;High Prevalence;Individual;Inequity;intersectionality;Intervention;Interview;Investigation;Knowledge;Latina Population;Latino;Latino Population;Limited English Proficiency;low socioeconomic status;Measurement;Measures;Medical;Medical Care Costs;Methods;Mexico;Modeling;moderate-to-vigorous physical activity;National Institute on Minority Health and Health Disparities;Neighborhoods;Occupational injury;Pain;Pain management;Pain Nature;pain perception;Pathway interactions;Patients;Persons;Phase;Physical activity;Population;Predictive Factor;prevent;Psychosocial Factor;Public Health;Reporting;Research;Research Design;Research Methodology;Research Personnel;Risk;Sampling;Science;secondary analysis;Social Identification;social structure;Social support;Spine pain;Strategic Planning;Structure;Subgroup;Target Populations;Testing;Time;Time Factors;Training;United States;United States National Institutes of Health;Wages;walkability;Woman

PROJECT_TITLE: Evaluating Multilevel Factors that Predict Physical Activity Among Latinos with Chronic Spine Pain: A Mixed-Methods Study


NIH_SPENDING_CATS: Burden of Illness;Clinical Research;Diabetes;Digestive Diseases;Genetic Testing;Genetics;Pediatric;Prevention

ORG_CITY: IOWA CITY

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Project Narrative Chronic pancreatitis (CP) is an emerging, but poorly understood condition in children that significantly impacts quality of life with high healthcare costs. The objective of this application is to delineate the natural history of pediatric CP through careful prospective analysis of INSPPIRE-2 cohort, to define the impact of genetic modifiers on disease course and to determine the mechanisms involved in pancreatogenic diabetes mellitus. Our long-term goal is to develop diagnostic modalities, prognostic factors and better treatment approaches for pediatric chronic pancreatitis.

PI_NAMEs: LOWE, MARK E.;UC, ALIYE  (contact)

PROGRAM_OFFICER_NAME: UNALP-ARIDA, AYNUR

PROJECT_TERMS: Acute;acute pancreatitis;Adult;Age;Aggressive course;Ancillary Study;Autoantibodies;Autoimmunity;Beta Cell;blood glucose regulation;burden of illness;C-Peptide;Characteristics;Child;Childhood;chronic pancreatitis;Clinical;clinical predictors;Cognitive Therapy;cohort;Cohort Analysis;Cystic Fibrosis Transmembrane Conductance Regulator;Defect;demographics;Diabetes Mellitus;Diagnosis;Diagnostic;diagnostic development;Disease;Disease Progression;early onset;Endocrine;Environmental Risk Factor;Exocrine pancreatic insufficiency;Fibrosis;Functional disorder;Funding;Genes;Genetic;Genetic Risk;genetic risk factor;Genetic Screening;genetic variant;genomic locus;Glucagon;glucagon-like peptide 1;Glucose;glucose tolerance;Goals;Health Care Costs;health related quality of life;Hyperlipidemia;Hypertriglyceridemia;Image;Impaired health;Incidence;innovation;insight;Insulin;Interdisciplinary Study;International;islet;Islet Cell;longitudinal analysis;Longitudinal cohort study;Modality;Natural History;Onset of illness;Outcome;Pain;pain-related disability;Pancreatic Polypeptide;Pancreatitis;Pathogenicity;Patient Outcomes Assessments;Pediatric cohort;Peptides;Physiologic calcification;polypeptide;Predisposing Factor;premature;Prevalence;Prognostic Factor;prospective;Quality of life;Recurrence;Research Personnel;response;Risk;Risk Factors;Risk Marker;risk variant;SPINK1 gene;Susceptibility Gene;Testing;Therapeutic;United States National Institutes of Health;Variant;virulence gene;Work

PROJECT_TITLE: INSPPIRE: A Longitudinal Cohort Study of Pediatric Chronic Pancreatitis to Predict Clinical Course and Identify Disease Modifiers


NIH_SPENDING_CATS: Clinical Research;Digestive Diseases;Lymphatic Research;Palliative Care

ORG_CITY: SAINT LOUIS

ORG_DEPT: PATHOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Backwards lymph flow in the intestine and mesentery may underlie protein-losing enteropathy (PLE). Here, we will apply a novel approach to functionally image and quantify lymphatic transport from the gut to the lymphovenous valve to better understand the role of lymphatics in PLE. We will evaluate a “2-hit” hypothesis that (1) impaired lymphatic flow and (2) inflammatory loss of valve integrity combine to drive clinically significant PLE.

PI_NAMEs: RANDOLPH, GWENDALYN J (contact)

PROGRAM_OFFICER_NAME: GREENWEL, PATRICIA

PROJECT_TERMS: Affect;Blood;Blood Vessels;Budesonide;Child;Circulation;clinically significant;Common Ventricle;Complication;Confusion;Crohn's disease;Disease;Epithelial Cells;Epithelium;Etiology;Experimental Animal Model;Failure;Functional Imaging;Heart;Heart Ventricle;Human;improved;Inflammatory;Intercellular Junctions;intestinal barrier;intestinal epithelium;Intestines;Lamina Propria;Life;Link;Liquid substance;Literature;Lung;Lymph;lymph flow;Lymphatic;lymphatic circulation;lymphatic dysfunction;Lymphatic System;lymphatic valve;lymphatic vasculature;Mesentery;Modeling;mortality;novel strategies;palliation;Participant;Pathologic;Patients;pressure;Procedures;Protein-Losing Enteropathies;Proteins;Research;Role;Signal Transduction;stem;Steroids;Testing;Tissues;Venous system

PROJECT_TITLE: Defining the lymphatic basis of protein losing enteropathy after Fontan palliation or inflammatory gut disease


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

ORG_CITY: Princeton

ORG_DEPT: CHEMISTRY

ORG_NAME: PRINCETON UNIVERSITY

ORG_STATE: NJ

PHR: Project Narrative The development of novel methods to directly introduce molecular complexity can significantly advance synthetic and medicinal chemistry by streamlining the synthesis of biologically relevant molecules. The objective of this proposed research is the development of a novel synthetic platform for the catalytic generation of alkene radical cation intermediates from simple alcohols via visible light photocatalysis to enable the development of new synthetic methods outside the scope of existing technologies. This work will provide a novel entry point to both classical and non-classical reactive intermediates and enable the rapid synthesis of pharmaceutically relevant molecules and analog libraries for medicinal chemistry.

PI_NAMEs: THACH, DANNY  (contact)

PROGRAM_OFFICER_NAME: JONES, LATAISIA CHERIE

PROJECT_TERMS: Alcohol consumption;Alcohols;Alkenes;analog;Anions;Bypass;career;Catalysis;Cations;Characteristics;chemical reaction;Chemicals;Chemistry;Complex;Coupled;design;Development;Electron Transport;Electrons;functional group;Generations;Glean;Goals;Health;Human;Hydrogen Bonding;improved;inorganic phosphate;insight;Libraries;Logic;Medicine;Methodology;Methods;Modernization;Molecular;Nature;novel;nucleotide analog;nucleotide metabolism;Nucleotides;Oligonucleotides;Organic Synthesis;oxidation;Oxidation-Reduction;Pharmaceutical Chemistry;Phosphorylation;progenitor;Protons;Reaction;Research;Research Proposals;Science;Site;small molecule;Synthesis Chemistry;Technology;tool;Training;United States National Institutes of Health;Visible Radiation;Work

PROJECT_TITLE: New Synthetic Methods Utilizing Radical Cation Intermediates Enabled by Visible Light Photocatalysis


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Breast Cancer;Cancer;Cancer Genomics;Genetics;Human Genome;Women's Health Research

ORG_CITY: LA JOLLA

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE The instability of the cancer genome, a driver of malignant evolution, can be targeted for the rational design of therapy, exemplified by the application of PARP inhibitors as maintenance therapy for cancers with BRCA1 or BRCA2 defects that inactivate homologous recombination repair (HRR) of genomic DNA. From yeast genetic studies of synthetic lethal interactions among genome instability suppressor genes, we identified and verified that HRR-deficiency also sensitizes cancer cells to the loss of the FEN1 endonuclease. This study will investigate the FEN1 endonuclease as a rational drug target for HRR-deficient cancers and establish a platform for further identification of synthetic lethal interactions to target cancer genome instability.

PI_NAMEs: KOLODNER, RICHARD D (contact);PUTNAM, CHRISTOPHER DAVID;WANG, JEAN Y.J.

PROGRAM_OFFICER_NAME: WEINREICH, MICHAEL DALE

PROJECT_TERMS: Ablation;Acceleration;Affect;Antineoplastic Agents;Base Excision Repairs;Biological Assay;Biological Models;brca gene;BRCA1 gene;BRCA1 Mutation;BRCA2 gene;BRCA2 Mutation;Breast Cancer cell line;Breast Cancer therapy;cancer cell;Cancer cell line;cancer genome;cancer genomics;cancer therapy;cancer type;candidate selection;candidate validation;Cell Line;Cells;Chromosomal Rearrangement;Chromosome Breakage;Chromosomes;Clustered Regularly Interspaced Short Palindromic Repeats;Colorectal Cancer;Data;Defect;Dependence;Development;Diploid Cells;DNA;DNA biosynthesis;DNA replication fork;DNA sequencing;Double Strand Break Repair;Dropout;Drug Targeting;endonuclease;Engineering;Epigenetic Process;Essential Genes;Evaluation;Evolution;Frequencies;Genes;Genetic;Genetic study;genome integrity;genome-wide;Genomic DNA;Genomic Instability;Genomics;Germ-Line Mutation;Goals;Guide RNA;Hereditary Breast and Ovarian Cancer Syndrome;Homologous Gene;homologous recombination;homologous recombination deficiency;Human;Human Genome;improved;in silico;In Vitro;in vivo;Informatics;Inherited;inhibitor;knock-down;Knock-out;Knowledge;Laboratories;Lethal Genes;Libraries;Maintenance Therapy;Malignant - descriptor;Malignant Breast Neoplasm;Malignant neoplasm of ovary;Malignant Neoplasms;Measures;Metaphase;Mining;Mus;mutant;Mutate;Mutation;nuclease;Okazaki fragments;PARP inhibition;Pathway Analysis;pharmacologic;Poly(ADP-ribose) Polymerase Inhibitor;predictive signature;Process;Progression-Free Survivals;rational design;recombinational repair;replication stress;Research;Resistance;resistance mechanism;response;RTH-1 Nuclease;Screening Result;Small Interfering RNA;small molecule;Specificity;Suppressor Genes;synthetic lethal interaction;targeted cancer therapy;Testing;Therapeutic Agents;therapeutic development;therapeutic target;therapy design;transcriptomics;tumor xenograft;Validation;validation studies;yeast genetics;yeast genome;Yeasts

PROJECT_TITLE: FEN1 Endonuclease as a Synthetic Lethal Target for Cancer Therapy

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 2 Study Section[MCT2]


NIH_SPENDING_CATS: Cachexia;Cancer;Complementary and Integrative Health;Natural Products;Nutrition;Obesity;Prevention

PHR: PROJECT NARRATIVE Obesity increases the risk of cancer; thus, individuals that are obese are more likely to undergo chemotherapy in their lifetime. While it is common practice to apply a dosing cap, current recommendations for the treatment of obese cancer patients is full body surface area chemotherapy dosing regimens despite some evidence suggesting that these patients may have exacerbated drug toxicities including perturbations to skeletal muscle mitochondrial function. The primary goal of my proposed F31 is to 1) understand the impact of obesity on chemotherapy-induced skeletal muscle mitochondrial dysfunction and 2) provide mechanistic and therapeutic insights aimed at better improving chemotherapy tolerance with obesity.

PI_NAMEs: CARDACI, THOMAS  (contact)

PROGRAM_OFFICER_NAME: BOULANGER-ESPEUT, CORINNE A

PROJECT_TERMS: Activities of Daily Living;Animal Cancer Model;anti-cancer;Antioxidants;Biogenesis;Body mass index;Body Surface Area;Body Weight;C26 tumor;Cachexia;Cancer Cachexia;Cancer Patient;Cancer Prognosis;cancer risk;Cancer Survivorship;cancer therapy;carcinogenesis;chemotherapy;Colorectal;Data;Development;Diet;dietary;dietary antioxidant;dietary approach;Dietary Practices;Dihydropyrimidine Dehydrogenase;Disease;Dose;Drug toxicity;Enzymes;Epidemiology;Fatigue;Fluorouracil;Functional dependence;Functional disorder;Goals;Half-Life;Health;improved;insight;Knowledge;Literature;Liver;loss of function;Maintenance;Malignant Neoplasms;Metabolic;Metabolic dysfunction;Metabolism;Mitochondria;mitochondrial dysfunction;Modeling;Morbidity - disease rate;Morphology;Mus;muscle form;Muscle function;Muscle Mitochondria;Natural Compound;Natural Products;novel;Obese Mice;obese person;Obesity;obesity treatment;Pathology;Patients;Pharmaceutical Preparations;pharmacologic;Phenotype;Positioning Attribute;Postdoctoral Fellow;prevent;Process;protein degradation;Publishing;Quality Control;Quality of life;Quercetin;Recommendation;Recording of previous events;Regimen;Research;Respiration;Role;Skeletal Muscle;Source;Testing;Therapeutic;Thinness;Toxic effect;Training;Transgenic Mice;Treatment Efficacy;Treatment outcome;tumor;Weight

PROJECT_TITLE: Impact of obesity on chemotherapy-induced muscle mitochondrial dysfunction


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Cannabidiol Research;Cannabinoid Research;Clinical Research;Complementary and Integrative Health;Drug Abuse (NIDA only);Natural Products;Opioid Misuse and Addiction;Opioids;Patient Safety;Prescription Drug Misuse;Substance Misuse;Therapeutic Cannabinoid Research

ORG_CITY: PULLMAN

ORG_DEPT: PHARMACOLOGY

ORG_NAME: WASHINGTON STATE UNIVERSITY

ORG_STATE: WA

PHR: Project Narrative Hydrocodone is one of the most prescribed and abused opioids in the USA. With the legalization of cannabis across the USA, the use of cannabis for medicinal purposes is also increasing, resulting in increases in the concomitant use of both drugs in the population. As the effect cannabis may have on an individual who is taking hydrocodone is unknown and may cause adverse drug events, the goal of the proposed studies will be to identify potential drug-drug interaction between major cannabinoids and their metabolites and hydrocodone and determine whether these interactions may result in adverse drug events and allow for new medical guidance.

PI_NAMEs: COATES, SHELBY  (contact)

PROGRAM_OFFICER_NAME: LIN, YU

PROJECT_TERMS: Adolescent;Adult;Adverse drug event;Analgesics;Biological Assay;Cannabidiol;Cannabinoids;Cannabinol;Cannabis;Carboxylic Acids;Cells;Clinical;Clinical Trials;clinically relevant;CYP2D6 gene;CYP3A4 gene;Cytochrome P450;Data;demethylation;Development;Dose;Drug Interactions;Drug Kinetics;Enzymes;Exhibits;Future;Gene Frequency;Genetic Variation;Glucuronides;Glucuronosyltransferase;Goals;Human;Hydrocodone;Hydromorphone;Illicit Drugs;In Vitro;in vivo;Individual;Knowledge;Liver Microsomes;marijuana legalization;Marijuana Smoking;marijuana use;Medical;Medical Marijuana;Metabolism;Minor;Modeling;mu opioid receptors;Nature;Neurons;neurotransmitter release;Opioid;opioid abuse;Opioid agonist;opioid epidemic;opioid use;Pain management;Parents;Pharmaceutical Preparations;pharmacokinetic model;physiologically based pharmacokinetics;Plasma;Population;prescription opioid;prescription opioid misuse;Recombinants;Regimen;Research;Site-Directed Mutagenesis;System;Tetrahydrocannabinol;UGT2B7 UDP-glucuronosyltransferase;Variant

PROJECT_TITLE: Drug-drug interactions between cannabis and hydrocodone.


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Immunization;Immunotherapy;Lung;Lung Cancer;Vaccine Related

ORG_CITY: FARMINGTON

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT

ORG_STATE: CT

PHR: PROJECT NARRATIVE Alternative splicing is a post-transcriptional regulatory process that is dysregulated in cancer and may generate unique peptides, called neoantigens, that can be recognized by antitumor CD8+ T cells. We have built a bioinformatic pipeline that has identified 21 candidate alternative splicing-derived neoantigens in non-small cell lung cancer, a deadly cancer type. The experiments outlined in this proposal will determine how these molecules contribute to the immunogenicity of non-small cell lung cancer, which may facilitate the development of new immunotherapies for this devastating disease.

PI_NAMEs: ENGLANDER, RYAN  (contact)

PROGRAM_OFFICER_NAME: BIAN, YANSONG

PROJECT_TERMS: Alternative Splicing;Amino Acid Sequence;anti-PD-1;anti-tumor immune response;Antigen Targeting;Antigens;Automobile Driving;Binding;Binding Sites;bioinformatics pipeline;Biological Assay;cancer cell;Cancer cell line;Cancer Etiology;Cancer Patient;cancer type;Cancer Vaccines;candidate identification;career;CD8-Positive T-Lymphocytes;Cell surface;Cells;Cessation of life;Coculture Techniques;Code;cohort;crosslink;cytokine;Cytomegalovirus;Data;Databases;Development;Disease;Exons;experimental study;Flow Cytometry;Frequencies;Genes;genetic approach;Genomics;Genotype-Tissue Expression Project;Goals;Human;Human Herpesvirus 4;Immune checkpoint inhibitor;Immune response;immunogenic;immunogenicity;Immunology;Immunoprecipitation;Immunotherapy;improved;in silico;In Vitro;Influenza;insight;Interferon Type II;Introns;Knock-out;Lead;Length;lung cancer cell;Malignant Neoplasms;Maps;Measurement;Measures;Mediating;Messenger RNA;Methods;MHC Class I Genes;mortality;mRNA Expression;mRNA Precursor;neoantigens;neoplastic cell;Non-Small-Cell Lung Carcinoma;Normal tissue morphology;novel;overexpression;Pathway interactions;Patient Care;Patients;Peptides;Peripheral Blood Mononuclear Cell;Physicians;Physiologic pulse;posttranscriptional;Primary Neoplasm;Process;Production;Proliferating;protein aminoacid sequence;Protein Isoforms;Proteins;public database;Research;response;RNA Splicing;RNA-Binding Proteins;Sampling;Scientist;Solvents;Sorting;Source;Surface;T cell response;T-Cell Activation;T-Lymphocyte;Techniques;Testing;The Cancer Genome Atlas;Training;Transcription Process;transcriptome sequencing;Translating;tumor;Tumor Antigens;Tumor Expansion;tumor specificity;United States;Vaccines;Viral;Work

PROJECT_TITLE: Alternate splicing as a source of shared neoantigens in a non-small cell lung cancer


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

ORG_CITY: BOSTON

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

ORG_STATE: MA

PHR: Narrative Neural circuits in the medial entorhinal cortex are critical for spatial navigation, learning, and memory. The completion of this project will provide mechanistic insight into how excitatory and inhibitory neurons in layer II/III mEC synchronize to generate theta-nested gamma oscillations observed during spatial navigation. A map of functional connectivity as well as the extent of recurrent excitation and inhibition between stellate, pyramidal, and fast-spiking interneurons, will provide a foundation for developing accurate models of spatially tuned neurons and grid cell formation.

PI_NAMEs: WILLIAMS, BRANDON DAVID (contact)

PROGRAM_OFFICER_NAME: MATTHEWS, MARGUERITE

PROJECT_TERMS: Academic Training;Action Potentials;Animals;Biological Sciences;Boston;Brain;Cell model;cell type;Cells;collaborative environment;Communication;Communities;Computer Models;Cortical Synchronization;Data;Development;Electrodes;Ensure;entorhinal cortex;excitatory neuron;Excitatory Synapse;Exhibits;extracellular;Feedback;Fostering;Foundations;Frequencies;Gap Junctions;Generations;Home;Image;inhibitory neuron;insight;Interneurons;Intracellular Membranes;Label;Learning;Maps;Measures;Medial;Memory;Mentorship;Modeling;multidisciplinary;Mus;neural circuit;neuromechanism;Neurons;Neurosciences;optogenetics;Output;patch clamp;Pattern;pharmacologic;Phase;Physiological;Play;Population;Positioning Attribute;postsynaptic;Prevalence;Pyramidal Cells;Recurrence;redshift;Research;Research Personnel;Research Project Grants;Role;sensor;skills;Slice;Spatial Behavior;standard measure;success;Synapses;System;Technical Expertise;Techniques;Testing;Time;Universities;voltage;voltage clamp;way finding

PROJECT_TITLE: Mechanisms of Neural Synchrony in the Medial Entorhinal Cortex


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE This proposal seeks to provide a transformative 12-week summer education, research and clinical experience that encourages undergraduate students to pursue careers that will advance progress in kidney and urinary tract related research and career development. This program is specifically designed to attract minorities and students from underserved and disadvantaged communities with the long-term goal to reduce heath disparities and increase the workforce in the fields of Nephrology and Urology.

PI_NAMEs: MCHUGH, KIRK M. (contact);SPENCER, JOHN DAVID

PROGRAM_OFFICER_NAME: MARIC-BILKAN, CHRISTINE

PROJECT_TERMS: Acceleration;Address;Adult;Affinity;American;Anatomy;Basic Science;career;Career Choice;career development;Career Mobility;Caring;Childhood;Chronic Kidney Failure;Clinical;clinical practice;Data;Data Analyses;design;Development;Disease;Education;education resources;End stage renal failure;experience;Exposure to;faculty mentor;Fostering;Foundations;Genitourinary system;Goals;Grant;hands on research;Health;improved;innovation;Institution;interest;Kidney;Kidney Diseases;Knowledge;Laboratories;Measures;Mentors;Minority;Modeling;multidisciplinary;National Institute of Diabetes and Digestive and Kidney Diseases;neighborhood disadvantage;Nephrology;next generation;Ohio;Patient Care;Pediatric Hospitals;Persons;Physicians;Physiology;Population;programs;Reduce health disparities;Research;research and development;Research Personnel;Research Training;Scientist;skills;Structure;Students;summer program;summer research;Talents;Training;Training Programs;Translational Research;translational research program;trend;undergraduate student;underserved community;underserved students;United States National Institutes of Health;Universities;Urinary tract;Urologic Diseases;Urology;Writing

PROJECT_TITLE: Nephrology & Urology Workforce Pipeline

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Immunotherapy;Neurosciences;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE Decades of clinical trials have not improved overall survival of pediatric patients diagnosed with H3K27M- mutant diffuse midline glioma (DMG). H3K27M-mutant DMG is one of the most challenging cancers to treat due to its location within delicate regions of the brain and its highly aggressive nature. We outline in this proposal a series of studies that will evaluate a new therapeutic target for the treatment of H3K27M-mutant DMG.

PI_NAMEs: CRENTSIL, HANNAH  (contact)

PROJECT_TERMS: Affect;Astrocytes;BCL10 gene;Biological Response Modifiers;Blood - brain barrier anatomy;Brain;Brain region;Brain Stem;cancer cell;cancer type;career;Categories;cell killing;cell motility;Cell Survival;Cells;Childhood;Childhood Brain Neoplasm;Childhood Brain Stem Neoplasm;Clinical Trials;Coculture Techniques;Complex;Cytoplasmic Protein;Data;Development;Diagnosis;diffuse midline glioma;effective therapy;epigenome;Excision;experience;experimental study;Fostering;Genes;Genetic Transcription;Glioblastoma;Glioma;H3 K27M mutation;Histone H3.3;Immune;immune activation;immune cell infiltrate;Immunity;Immunofluorescence Immunologic;improved;In Vitro;Individual;Infiltration;inhibitor;Invaded;Laboratories;Location;Lymphocyte Depletion;Malignant - descriptor;Malignant Childhood Neoplasm;Malignant Neoplasms;Mentorship;Microglia;Midbrain structure;migration;Modeling;Molecular;mouse model;Mucosa- associated lymphoid tissue lymphoma translocation protein-1;Mus;Myelogenous;Nature;Neoplasms;new therapeutic target;NF-kappa B;novel;novel therapeutic intervention;Operative Surgical Procedures;Pathogenesis;Patients;pediatric patients;Peptide Hydrolases;pharmacologic;Pharmacologic Substance;Phenothiazines;Physicians;Play;Point Mutation;Pontine structure;Proliferating;Protease Inhibitor;protein complex;Proteins;Radiation;Radiation therapy;Research Personnel;Research Training;response;Role;Sampling;scaffold;Scientist;Series;Signal Transduction;single-cell RNA sequencing;standard care;Structure;Techniques;Testing;Therapeutic;Training;translational therapeutics;tumor;tumor growth;Tumor Immunity;tumor microenvironment;tumor progression;Tumor-associated macrophages;tumor-immune system interactions;Tumor-infiltrating immune cells;Wild Type Mouse

PROJECT_TITLE: MALT1 protease as a regulator of anti-tumor immunity and tumor progression in diffuse midline glioma


PHR: Project Narrative Optogenetics is a promising approach to understanding cellular regulation, but current efforts to recreate synthetic circuits are hampered by a limited toolset of multi-chromatic, orthogonal regulatable proteins. This proposal will multiplex new light regulatable tools to exert control over gene expression. This knowledge will inform engineering approaches to improve control over proteins and/or RNA in mammalian cells.

PI_NAMEs: TOUS, CRISTINA  (contact)

PROGRAM_OFFICER_NAME: STAMM, JOYCE CHIN-CHIN NG

PROJECT_TERMS: analog;Architecture;Automobile Driving;Biological;Biological Assay;cell behavior;Cell Fate Control;cell growth regulation;Cell Physiology;Cell Therapy;Cells;cellular transduction;Chemicals;Complex;Darkness;Degradation Pathway;Development;Diffuse;disease model;DNA Sequence;empowerment;Engineering;Enzymes;Flow Cytometry;Gene Expression;Gene Expression Regulation;gene interaction;gene repression;Genes;Genetic;genetic regulatory protein;Genetic Transcription;Geometry;Growth Factor;Guide RNA;Image Analysis;improved;Individual;knock-down;Knowledge;Libraries;Light;Lighting;Logic;Luciferases;Mammalian Cell;mammalian genome;mechanical signal;Memory;Modeling;multipotent cell;Muscle Fibers;Myoblasts;Nuclear RNA;nuclease;Optics;optogenetics;osteoblast differentiation;Osteoblasts;Output;Pathway interactions;Pattern;Post-Transcriptional Regulation;Proteins;quantitative imaging;recombinase;reconstitution;Regulation;Reporter;Resolution;Ribonucleases;RNA;RNA Degradation;RNA Interference;Role;screening;Signal Pathway;Signal Transduction;Site;spatiotemporal;Specificity;Stains;System;tissue regeneration;tool;transcription factor;transcriptome;transcriptomics;Transfection;transgene expression;Transgenes;Work

PROJECT_TITLE: Multiplexed Optogenetic Control of Mammalian Genome and Transcriptome using Recombinases and Cas13

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F08-A(20)L]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Mental Health;Mental Illness;Neurosciences

ORG_DEPT: PSYCHOLOGY

ORG_NAME: NORTHEASTERN UNIVERSITY

PHR: Project Narrative Negative mood is a transdiagnostic feature of mental illnesses that together impose an economic burden of more than $600 billion annually in the US and inflict immeasurable human suffering. Conceptual and methodological barriers have slowed scientific discovery of the brain basis of negative affect. I will surmount these barriers with innovative analyses of an existing ultra-high field fMRI data set to test novel hypotheses about a neural circuit involved in negative affect.

PI_NAMEs: DEMING, PHILIP  (contact)

PROGRAM_OFFICER_NAME: PINARD, COURTNEY ROSE

PROJECT_TERMS: Affect;affective neuroscience;Anatomy;Anterior;Anxiety;Architecture;Area;area striata;Bipolar Disorder;Brain;career;Cerebral cortex;Cognition;Collaborations;Computer Models;cost;Country;Data;Data Set;Development;Diagnostic;Disease;Economic Burden;Emotions;Engineering;experience;Functional Magnetic Resonance Imaging;Goals;Human;human subject;Hypothalamic structure;Image;innovation;Learning;Mammals;Measures;Mental Depression;Mental disorders;Methodology;Methods;Mood Disorders;Moods;Motor;Movement;negative affect;negative mood;Negative Valence;neural circuit;neuroimaging;next generation;novel;Participant;Pattern;Perception;Positioning Attribute;post-doctoral training;prevent;psychologic;Public Health;Research;Research Domain Criteria;Resolution;Sampling;Schizophrenia;Schools;Scientist;Sensory;sensory cortex;Signal Transduction;skills;somatosensory;Stimulus;Structural Models;Structure;Techniques;Testing;theories;Training;Visual

PROJECT_TITLE: Probing negative affect circuits in humans using 7T fMRI


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Breast Cancer;Cancer;Genetics;Neurosciences;Orphan Drug;Rare Diseases;Women's Health Research

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Project Narrative This project will study two long non-coding RNAs (lncRNAs), that affect cellular function directly as RNAs, without being translated into proteins, and are known to regulate progression of gliomas: an oncogene LINC00152 and a tumor suppressor DRAIC. In the F99 phase, I will focus on structure-function studies of the lncRNAs that will identify the minimal regions of these RNAs important for their action and thus identify how these lncRNAs regulate glioma progression, while in parallel familiarizing myself with animal models and histopathology of gliomas. In the K00 phase, I will focus on two strategies for therapy of gliomas based on the knowledge obtained during the F99: methods of targeting/delivering lncRNAs in gliomas and screening for small chemicals that will reverse the actions of the lncRNAs.

PI_NAMEs: PRZANOWSKA, ROZA KAMILA (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: Accounting;Adult;Affect;Algorithms;Angiogenesis Inhibitors;Animal Model;Antineoplastic Agents;Antisense Oligonucleotides;Benign;bevacizumab;Bioinformatics;Biological Assay;biomarker discovery;Brain;Brain Neoplasms;Cancer Biology;Cancer Model;Cancer Prognosis;career;cell motility;Cell Physiology;Cells;Central Nervous System Neoplasms;Cessation of life;Chemicals;Chemotherapy and/or radiation;Classification;Clinical Trials;Combined Modality Therapy;comparative;Data;design;Diagnosis;Diagnostic;Disease;Disease remission;Drug Targeting;effective therapy;Epigenetic Process;Estrogen receptor positive;Evaluation;Excision;Exhibits;Exons;experimental study;FDA approved;Focused Ultrasound;Future;Genes;Glioblastoma;Glioma;Gold;Grant;Heterogeneity;Histopathology;Immune response;Immune system;Immunotherapy;improved;in vivo;Invaded;Knowledge;Location;Malignant - descriptor;Malignant Breast Neoplasm;Malignant neoplasm of brain;Malignant Neoplasms;Maps;Methodology;Methods;MicroRNAs;migration;mouse model;Mus;nanoparticle;National Cancer Institute;Neoplasm Metastasis;Nervous System;Nervous System Neoplasms;neuropathology;NF-kappa B;novel;novel strategies;novel therapeutic intervention;Oncogenes;Oncogenic;Oncolytic viruses;Operative Surgical Procedures;Organism;overexpression;Pathway interactions;Patients;Phase;Phosphotransferases;Postdoctoral Fellow;pre-doctoral;Prognosis;Proteins;Quality of life;Recurrence;Regulation;Regulatory Pathway;Research;Research Design;Research Personnel;Research Project Grants;Risk;RNA;RNA delivery;Role;Scientist;screening;Series;Signs and Symptoms;Specimen;Structure;Structure-Activity Relationship;targeted treatment;Techniques;Testing;Therapeutic;therapeutic RNA;therapy development;Time;Training;Translating;tumor;Tumor Antibodies;Tumor Burden;tumor growth;tumor progression;Tumor Suppression;Tumor Suppressor Proteins;Untranslated RNA;Work;Xenograft procedure

PROJECT_TITLE: Long non-coding RNA Heterogeneity in ER + Breast Cancer


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Infectious Diseases;Wound Healing and Care

ORG_CITY: IRVINE

ORG_DEPT: PHYSICS

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: Project Narrative  The effective treatment of bacterial infections of skin, deep soft tissues and wounds continues to be a major unmet healthcare challenge, especially in patients whose antimicrobial responses are compromised by underlying diabetes. The proposed work seeks to establish a new class of antimicrobials, inspired by immune cells, that are synergistic through the combination of histones with agents that target the outer surface of bacteria. The successful outcome of this work would provide fundamental insight into a novel antimicrobial mechanism and produce important pre-clinical data for the development of new therapeutics that treat skin, soft tissue, and wound infections.

PI_NAMEs: SIRYAPORN, ALBERT  (contact)

PROGRAM_OFFICER_NAME: XU, ZUOYU

PROJECT_TERMS: Address;anti-microbial peptide;Antibiotic Resistance;Antibiotics;antimicrobial;antimicrobial peptide LL-37;Attention;Bacteria;Bacterial Antibiotic Resistance;Bacterial Infections;bactericide;Bacteriology;Biology;Biophysics;cathelicidin;cathelicidin antimicrobial peptide;Cell Wall;Cells;Cellular biology;Cessation of life;Chemicals;Chronic;chronic wound;combat;Communities;Cryoelectron Microscopy;Data;design;Development;Diabetes Mellitus;diabetic;Diabetic mouse;DNA;effective therapy;Engineering;experimental study;extracellular;Fiber;Foundations;Gene Expression;Goals;health care settings;Healthcare;Histone H2A;histone modification;Histones;Human;human pathogen;Immobilization;Immune;Immunology;In Vitro;in vivo;Infection;Infectious Skin Diseases;inhibitor;innovation;insight;Interdisciplinary Study;Malignant Neoplasms;Measures;Membrane;methicillin resistant Staphylococcus aureus;microbial;microbial community;Modeling;Modernization;Modification;Morbidity - disease rate;mortality;mouse model;Multi-Drug Resistance;Mus;neutrophil;next generation;non-diabetic;non-healing wounds;novel;novel strategies;novel therapeutics;Outcome;pathogen;pathogenic bacteria;Pathway interactions;Patients;Peptidoglycan;pre-clinical;Proliferating;Pseudomonas aeruginosa;ramoplanin;Reporting;Resistance;resistant strain;response;scaffold;Shapes;Skin;skin wound;soft tissue;Soft Tissue Infections;Standardization;Staphylococcus aureus;Surface;synergism;targeted agent;Testing;Therapeutic;uptake;Work;wound;Wound Infection

PROJECT_TITLE: Synergistic killing of bacterial pathogens by histones

STUDY_SECTION: DDR

STUDY_SECTION_NAME: Drug Discovery and Mechanisms of Antimicrobial Resistance Study Section[DDR]


ORG_CITY: SEATTLE

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: Project Narrative The proper three-dimensional organization of DNA within the nucleus is critically important for healthy cells, and alterations to organization are associated with developmental disease and cancer. This research program aims to better characterize the patterns of DNA organization that occur in healthy cells and to investigate how these impact important cellular processes such as gene expression, DNA replication, and DNA repair. A more complete understanding of how 3D genome organization functions within the cell will provide key insights into why this process is associated with human disease and may inform new therapeutic strategies.

PI_NAMEs: BELIVEAU, BRIAN JOSEPH (contact)

PROGRAM_OFFICER_NAME: VATAKIS, DIMITRIOS NIKOLAOS

PROJECT_TERMS: 3-Dimensional;Address;Architecture;Bioinformatics;biophysical properties;Biophysics;cell fixing;Cell Nucleus;Cell Physiology;Cells;cellular imaging;Chromosome Mapping;Chromosome Structures;Chromosomes;Complex;cost;Data Set;design;Development;developmental disease;Diameter;DNA;DNA biosynthesis;DNA Repair;Environment;Fluorescent in Situ Hybridization;Frequencies;Gene Expression;Genetic Transcription;Genome;genome-wide;Genomics;Hi-C;human disease;Imaging technology;Individual;insight;live cell imaging;Malignant Neoplasms;Mammalian Cell;meter;Methods;Microscopy;nanoscale;novel therapeutic intervention;Nuclear;Oligonucleotide Probes;Optics;Pattern;physical property;Population;Process;programs;Proteins;repaired;Research;Resources;Sampling;screening;Signal Transduction;single molecule;Structure;superresolution microscopy;Techniques;Technology;Tissues;Trans-Activators;Visual;Work

PROJECT_TITLE: Probing the dynamics of chromosome organization in single cells

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-K(55)R]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Brain Cancer;Brain Disorders;Cancer;Immunization;Immunotherapy;Neurosciences;Orphan Drug;Precision Medicine;Rare Diseases

ORG_DEPT: NEUROSURGERY

PHR: PROJECT NARRATIVE The proposed project is relevant to public health because the development of informative non-invasive diagnostic imaging strategies to guide immunotherapies for gliomas will ultimately reduce the use of ineffective therapies, allow patients to attempt more promising personalized treatments, and result in improved response rates. Thus, the proposed research is relevant to the part of the NIH and NIBIB mission that pertains to improving health by leading the development and accelerating the application of biomedical technologies.

PI_NAMEs: EDWARDS, WILSON BARRY;KOHANBASH, GARY  (contact)

PROGRAM_OFFICER_NAME: DARDZINSKI, BERNARD JOSEPH

PROJECT_TERMS: Acceleration;Adult;Antibodies;antibody engineering;Antigens;base;Biological Monitoring;Biomedical Technology;Cancer Etiology;Cell surface;Cell Therapy;Cells;Cellular immunotherapy;chelation;Chemistry;chemotherapy;Child;Childhood;childhood cancer mortality;clinical decision-making;Clinical Research;clinically relevant;cross reactivity;Data;Development;Diagnostic Imaging;Effectiveness;Enrollment;epigenetic therapy;Excision;Future;Glioma;Goals;Health;Histologic;Human;imaging approach;imaging biomarker;imaging probe;Imaging Techniques;Immune Targeting;Immunoglobulin Fragments;Immunologics;Immunosuppression;Immunotherapeutic agent;Immunotherapy;immunotherapy trials;improved;ineffective therapies;ITGAM gene;Label;Magnetic Resonance Imaging;Malignant Glioma;Mediating;Mission;Modeling;Molecular;molecular imaging;Monitor;Mus;Myeloid Cells;Myeloid-derived suppressor cells;National Institute of Biomedical Imaging and Bioengineering;non-invasive imaging;noninvasive diagnosis;novel;Outcomes Research;patient response;patient stratification;Patients;personalized medicine;Population;Positron-Emission Tomography;pre-clinical;precision medicine;preclinical study;prevent;Primary Brain Neoplasms;Process;Prognosis;Public Health;Publishing;Radiation therapy;Radioimmunoconjugate;Radiolabeled;radiotracer;recruit;Research;response;serial imaging;Specimen;standard of care;survival prediction;Survival Rate;T-Cell Activation;T-Lymphocyte;targeted imaging;Testing;Time;time interval;tool;Tracer;Translating;Treatment Cost;treatment response;Treatment Side Effects;tumor;Tumor Antigens;tumor microenvironment;Tumor Tissue;Tumor-associated macrophages;United States National Institutes of Health;unnecessary treatment;uptake;Work

PROJECT_TITLE: Engineered antibody fragments for PET imaging of immunotherapeutic targets in gliomas

STUDY_SECTION: IPCA

STUDY_SECTION_NAME: Imaging Probes and Contrast Agents Study Section[IPCA]


NIH_SPENDING_CATS: Digestive Diseases

ORG_DEPT: BIOLOGY

PHR: Project Narrative The inflammasome component NLRP3 is well known for its function in innate immunity, but its unexpected expression in T cells has sparked an exploration of its role in adaptive immunity. By taking both loss-of-function and gain-of-function approaches, this study will help gain mechanistic insights into the underappreciated anti- inflammatory role of NLRP3 in intestinal Tregs. The results obtained from this study will undoubtedly guide effective therapies for chronic intestinal disorders such as inflammatory bowel disease, in which the anti- inflammatory vs. proinflammatory role of NLRP3 is still debated.

PI_NAMEs: PATKAR, RASIKA  (contact)

PROGRAM_OFFICER_NAME: DENSMORE, CHRISTINE L

PROJECT_TERMS: Ablation;adaptive immunity;Affect;Anti-Inflammatory Agents;Antigens;Autoimmune;Bacterial Infections;Biological;Bone Marrow;CASP1 gene;Caspase;CD3 Antigens;Cell Physiology;Cells;Cellular biology;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Chimera organism;Chronic;Citrobacter rodentium;commensal microbes;Complex;constitutive expression;cytokine;Cytoplasm;Data;Development;Disease;disease model;effective therapy;Enteral;Exhibits;Food;FOXP3 gene;Frequencies;Future;gain of function;Genes;gut inflammation;Homeostasis;Human;IL17 gene;IL18 gene;Immune;Immune response;Immunity;immunoregulation;Infection;Inflammasome;Inflammation;Inflammatory;Inflammatory Bowel Diseases;insight;Interleukin-1;Interleukin-1 beta;Intestinal Diseases;intestinal homeostasis;Intestines;Knockout Mice;loss of function;Lymphoid;Measures;Mediating;Microbe;Modeling;Molecular;mouse model;Multiprotein Complexes;Mus;Natural Immunity;Nature;novel;Pathologic;Pathway interactions;Physiological;Play;Production;Proteins;Regulation;Regulatory T-Lymphocyte;Reporting;response;Role;Sorting;System;T cell differentiation;T cell response;T-Lymphocyte;T-Lymphocyte Subsets;Testing;Therapeutic;Tissues;Transcript;transcription factor;transcriptome sequencing

PROJECT_TITLE: Function of NLRP3 in regulatory T cell-mediated control of intestinal homeostasis


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Aphasia;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Epilepsy;Mental Health;Neurodegenerative;Neurosciences

ORG_CITY: WASHINGTON

ORG_DEPT: NEUROSCIENCES

ORG_NAME: GEORGETOWN UNIVERSITY

ORG_STATE: DC

PHR: PROJECT NARRATIVE Countless times per day, we must categorize and recognize objects in our visual environment to meaningfully and purposefully interact with our surroundings. This project aims to examine the neural correlates of where categorization occurs in the human brain, how it occurs under perceptual ambiguity, and how previous memories interact may mediate these neural computations. Investigating these questions in the human brain using highly spatiotemporally precise neuroimaging methods (iEEG and single-unit spiking data) will provide insight into the fundamental mechanisms of semantics, which will help with the early identification of cognitive impairments in Alzheimer’s Disease and other dementias as well as long-term treatment of epilepsy.

PI_NAMEs: STEINBERG, NOAH  (contact)

PROJECT_TERMS: Academic Medical Centers;Address;Affect;Alzheimer's Disease;Animals;Anterior;Area;area MT;Behavior;Behavioral;Brain;brain computer interface;Categories;Cognition;Cognitive;cognitive control;cognitive process;cognitive system;comparative;Computer Models;Dangerousness;Data;Data Collection;Decision Making;Dementia;Detection;Diffusion;Disease;dorsal visual stream;Early identification;Electrocorticogram;Electrodes;Environment;Epilepsy;Episodic memory;executive function;experience;extracellular;Feedback;forest;Goals;Health;Human;Image;Impaired cognition;Implanted Electrodes;improved;insight;Investigation;Knowledge;lateral intraparietal area;Lead;Learning;Link;Literature;medial temporal lobe;Mediating;member;Memory;Mentorship;Methods;Microelectrodes;millisecond;Modeling;Monitor;Monkeys;Motor;Movement;Mus;Nervous System Disorder;Nervous System Trauma;neural;neural correlate;neuroimaging;Neurologist;neuromechanism;Neurons;Neurosciences;neurotransmission;object recognition;Participant;Pathway interactions;Population;Prefrontal Cortex;Process;Reaction;recruit;Research;Research Personnel;Research Project Grants;Resolution;Resources;Role;Seizures;Semantic Dementias;Semantic memory;Semantics;Sensory;Signal Transduction;spatiotemporal;Statistical Data Interpretation;Stimulus;Stream;Stroke;System;Task Performances;Techniques;Technology;Temporal Lobe;Testing;Time;Training;ventral visual stream;Visual;visual information;visual stimulus;Visual System;Work

PROJECT_TITLE: The Neural Mechanisms Underlying Categorical Decision Making


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: COLD SPRING HARBOR

ORG_NAME: COLD SPRING HARBOR LABORATORY

PHR: PROJECT NARRATIVE The complex coordination of cis-regulatory elements (CREs), the so-called cis-regulatory code, regulates many biological processes, including transcriptional regulation and alternative splicing. This project will develop machine learning-based methods to decipher this code by quantitatively characterizing higher-order interactions within CREs and between multiple CREs using functional genomics data. This will have direct applications to fundamental problems in basic biological science as well as to the understanding and treatment of human diseases.

PI_NAMEs: KOO, PETER K (contact)

PROGRAM_OFFICER_NAME: WELLINGTON, CHRISTOPHER

PROJECT_TERMS: 5' Splice Site;Acceleration;Address;Alternative Splicing;base;Bayesian Analysis;Biological;Biological Assay;Biological Process;Biological Sciences;Black Box;Catalogs;ChIP-seq;Code;Communities;Complex;Computer Models;Computer software;computerized tools;Computing Methodologies;convolutional neural network;crosslinking and immunoprecipitation sequencing;Data;density;Dependence;design;Development;direct application;Disease;DNA;DNA Sequence;Elements;Exhibits;experimental study;functional genomics;Genetic;Genetic Transcription;Genome;genome-wide;genomic data;genomic locus;Genomics;Goals;human disease;improved;in silico;in vivo;Individual;insight;Knowledge;Laboratories;Learning;learning network;machine learning method;Maps;Methods;Modeling;Modernization;multiplex assay;Mutagenesis;Mutagens;Network-based;neural network architecture;Nucleotides;open source;Performance;Positioning Attribute;prototype;Regulatory Element;Resolution;RNA;RNA-Binding Proteins;sequence learning;Specific qualifier value;syntax;Training;transcription factor;Transcriptional Regulation;Translating;user-friendly;Variant;web server;Weight;Work

PROJECT_TITLE: Interpretable Computational Models of Functional Genomics Data

STUDY_SECTION: GCAT

STUDY_SECTION_NAME: Genomics, Computational Biology and Technology Study Section[GCAT]


NIH_SPENDING_CATS: Biotechnology;Cancer;Lung;Lung Cancer;Orphan Drug;Rare Diseases

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: NARRATIVE This grant focuses on novel therapeutic approaches to address small cell lung cancer, an exceptionally lethal disease, using multiple emerging technologies including single cell profiling and novel disease models based on direct modification of human tumors by genome editing in vivo. We will define and target a newly identified stem- like tumor subpopulation we have identified, analyze and target lineage plasticity as a mechanism of acquired drug resistance, and conduct screens to identify new and tractable therapeutic vulnerabilities in human small cell lung cancers.

PI_NAMEs: RUDIN, CHARLES M. (contact)

PROGRAM_OFFICER_NAME: FORRY, SUZANNE L

PROJECT_TERMS: acquired drug resistance;Address;Area;Biology;cancer genetics;cancer genome;cancer subtypes;cell type;Cells;Clinical;clinical prognosis;clinical translation;CRISPR/Cas technology;Data;Dependence;Disease;disease model;Distant Metastasis;Emerging Technologies;Evolution;Future;Genes;Genome;genome editing;Grant;Guide RNA;Hand;Histologic;Human;in vivo;Infiltration;Inter-tumoral heterogeneity;interest;Laboratories;Laboratory Research;Lung Adenocarcinoma;Macrophage;Malignant neoplasm of lung;Malignant Neoplasms;Modification;Molecular;new technology;new therapeutic target;Nodal;novel;novel therapeutic intervention;novel therapeutics;patient derived xenograft model;Patients;Population;prevent;Prognosis;rapid growth;research clinical testing;Resistance;RNA library;small cell lung carcinoma;stem;stem-like cell;System;Therapeutic;therapeutic development;therapy resistant;tool;Translating;Translational Research;tumor;Tumor Escape

PROJECT_TITLE: Novel therapeutic development for small cell lung cancer


ADMINISTERING_IC: HD

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Comparative Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurosciences;Physical Rehabilitation;Rehabilitation;Social Determinants of Health;Stroke

PHR: PROJECT NARRATIVE This study will fill gaps in our understanding of access to and effectiveness of rehabilitation care for patients discharged home following stroke. It will also determine the potential effectiveness of a transitional care model in improving access to and appropriate delivery of rehabilitation care. Findings from this study will inform care delivery at the patient-, provider-, health system-, and policy-levels and may have a significant impact on the health of the nearly 800,000 persons per year who experience a stroke.

PI_NAMEs: FREBURGER, JANET KUES (contact);JONES, SARA BINGHAM;PASTVA, AMY M

PROGRAM_OFFICER_NAME: MARDEN, SUSAN F

PROJECT_TERMS: accountable care organization;acute care;acute stroke;Address;Adverse event;American;Behavioral;bundled payment;care delivery;care episode;Caring;Characteristics;Clinic;Clinic Visits;Clinical;Clinical Data;Communities;community-level factor;Data;Data Analyses;Data Set;Development;differences in access;Disparity;Education;Effectiveness;effectiveness evaluation;efficacy study;Electronics;evidence base;experience;falls;geographic disparity;Geography;Health;health care service utilization;health determinants;Health system;Healthcare Systems;Home;hospital readmission;Hospitalization;Hospitals;Impaired cognition;Improve Access;Individual;Intervention;Measures;Modeling;motor impairment;Movement;North Carolina;Occupational Therapist;Occupational Therapy;Outcome;Patient Care;Patient Discharge;Patient Outcomes Assessments;Patient Self-Report;Patient-Focused Outcomes;Patients;personalized care;Persons;Physical Function;physical therapist;Physical therapy;Play;Policies;Population Study;post stroke;pragmatic trial;primary endpoint;programs;Provider;Race;Randomized;Recovery;Recurrence;Rehabilitation Outcome;Rehabilitation therapy;rehabilitative care;Reporting;Risk;Sampling;secondary endpoint;Secondary Prevention;Services;Site;social;sociodemographic disparity;sociodemographics;socioeconomics;Stroke;Stroke Belt;stroke outcome;stroke recovery;stroke rehabilitation;stroke survivor;Survivors;systematic review;Telephone;Transient Ischemic Attack;treatment as usual;Visit

PROJECT_TITLE: Access to and effectiveness of community-based rehabilitation after stroke

STUDY_SECTION: HSOD

STUDY_SECTION_NAME: Health Services Organization and Delivery Study Section[HSOD]


ED_INST_TYPE: SCHOOLS OF EDUCATION

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Drug Abuse (NIDA only);Maternal Health;Neurosciences;Opioid Misuse and Addiction;Opioids;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Social Determinants of Health;Substance Misuse;Women's Health Research

ORG_CITY: Nashville

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: PROJECT NARRATIVE Substance use in pregnant women has increased over the past decade, highlighting the importance of efforts to understand how environmental and other exposures during pregnancy affect brain development and child outcomes. The PRELUDE consortium for the HEALthy Brain and Child Development study will recruit 2720 pregnant women in the 2nd and 3rd trimester and follow their children to age 10, using neuroimaging, behavioral assessments, EEG, biosample collection, and assessments of parent-child interaction and the home environment. This research will lead to greater understanding of factors affecting early childhood brain development, allowing targeted interventions and improved outcomes for mother-child dyads.

PI_NAMEs: CUTTING, LAURIE E (contact);OSMUNDSON, SARAH SCHEIDERICH

PROGRAM_OFFICER_NAME: PRABHAKAR, JANANI

PROJECT_TERMS: addiction;Address;adverse outcome;Affect;Age;Alcohol consumption;Arkansas;Behavior assessment;Behavioral;Biological;Biological Factors;Birth;Brain;Child;Child Development;Childhood;clinical care;Clinical Research;Cognitive;cohort;Collaborations;Collection;Communities;community engagement;Data;Data Analyses;Data Coordinating Center;data exchange;Dedications;design;Development;early childhood;Electroencephalography;Emotional;Enrollment;Ensure;Environmental Risk Factor;Ethics;Ethnic Origin;evidence base;Exposure to;Family;fetal;Funding;General Population;Genetic;Geography;Goals;Helping to End Addiction Long-term;high risk;high risk infant;high risk population;Home environment;Image;improved;improved outcome;Infant;insight;Institution;Intervention;Legal;Longitudinal Studies;Magnetic Resonance Imaging;Maternal and Child Health;Maternal Health;maternal outcome;maternal stress;Measures;Medical center;Mental Health;Mothers;neurodevelopment;neuroimaging;neurophysiology;North Carolina;nutrition;Opiate Addiction;Opioid;opioid misuse;Outcome;Parent-Child Relations;Parents;Participant;Pediatric Hospitals;Phase;Physiological;post pregnancy;Poverty;Pregnancy;Pregnant Women;prenatal;Prenatal care;prenatal experience;prenatal exposure;Protocols documentation;Public Health;Questionnaires;Race;recruit;Research;Research Institute;resilience;Resources;Risk;Risk Factors;risk minimization;Sample Size;Sampling;School-Age Population;Second Pregnancy Trimester;Series;Site;social;socioeconomic diversity;Speed;stem;substance use;Third Pregnancy Trimester;Tobacco;Toxic Environmental Substances;United States National Institutes of Health;Universities;Visit;wearable device;Work

PROJECT_TITLE: 6/6 HBCD Prenatal Experiences and Longitudinal Development (PRELUDE) Consortium Vanderbilt

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-D(51)R]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Infectious Diseases;Lung

PHR: PROJECT NARRATIVE As evidenced by the recent SARS-CoV-2/COVID-19 pandemic, more rapid development of medicines that can be widely, quickly and easily implemented for new viruses would significantly reduce rates of hospitalization and death. Our goal is to develop oral drug cocktails that strongly inhibit SARS-CoV-2 circulating variants of concern and other coronaviruses that could seed future pandemics. Mathematical modeling will be employed at all stages to optimize drug combinations and will ultimately assist in the design of ready-to-launch clinical trial designs with combinations that are likely to be effective in people infected with SARS-CoV-2 or other coronaviruses.

PI_NAMEs: POLYAK, STEPHEN J. (contact);SCHIFFER, JOSHUA TISDELL

PROGRAM_OFFICER_NAME: BASU, DIPANWITA

PROJECT_TERMS: 2019-nCoV;Achievement;Anti-viral Agents;Antibodies;antiviral drug development;Authorization documentation;base;Belgium;Cell Line;Cells;Cessation of life;Clinical;Clinical Trials;Clinical Trials Design;Collaborations;Coronavirus;Coronavirus Infections;cost;COVID-19 pandemic;COVID-19 therapeutics;Data;design;Development;Disease Outbreaks;dosage;Dose;Drug Combinations;drug efficacy;Drug Interactions;Drug Kinetics;Drug resistance;Effectiveness;efficacy testing;Enzymes;Evolution;Experimental Designs;experimental study;Failure;Family;Future;future outbreak;future pandemic;General Population;global health;Goals;Hamsters;Hospitalization;hospitalization rates;Human;Immunocompromised Host;immunodeficient mouse model;improved;In Vitro;in vivo;in vivo evaluation;Incidence;Infection;Lead;Long COVID;Lower respiratory tract structure;Lung;mathematical methods;mathematical model;Measures;Medicine;Middle East Respiratory Syndrome;Modeling;molnupiravir;Monoclonal Antibodies;Mus;mutant;new epidemic;nirmatrelvir;novel;novel coronavirus;Oral;pandemic coronavirus;pandemic disease;pandemic preparedness;pandemic response;Patients;Paxlovid;Persons;Pharmaceutical Preparations;pharmacodynamic model;Pharmacodynamics;pharmacokinetic model;Plasma;Property;prophylactic;Prophylactic treatment;Protease Inhibitor;Readiness;Regimen;remdesivir;Research;Resistance;Resistance development;resistance mutation;response;Rodent;Rodent Model;SARS-CoV-2 B.1.1.529;SARS-CoV-2 infection;SARS-CoV-2 inhibitor;SCID Mice;Scientist;Self Administration;Severe Acute Respiratory Syndrome;Severities;small molecule;Source;success;Symptoms;synergism;Testing;Therapeutic;therapy duration;Time;Tissues;trial design;Upper respiratory tract;Vaccines;variants of concern;Viral;Viral Load result;viral outbreak;viral rebound;Virus;virus development;Virus Diseases;virus identification;Virus Replication;Virus Shedding;Work

PROJECT_TITLE: Development of an Oral Pan-Coronavirus Drug Cocktail


NIH_SPENDING_CATS: Autoimmune Disease;Behavioral and Social Science;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Pediatric;Prevention

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: PROJECT NARRATIVE Advanced management of children with type 1 diabetes (T1D) aims to utilize diabetes devices, such as insulin pumps (IP) and continuous glucose monitors (CGM), to optimize glycemic control; however, use of these devices has not resulted in the expected improvements in T1D outcomes. We will identify unmet psychoeducational needs in parents of children using IP and CGM to manage T1D and leverage this information to inform a feasibility and acceptability study assessing an app-delivered psychoeducational intervention intended to improve knowledge and alter behaviors related to diabetes technology use. Successful execution of this project will inform a future randomized controlled trial that will demonstrate the efficacy of an easily distributed psychoeducational tool that will help to realize the full potential of diabetes technologies while also providing Dr. Marks with the training and mentorship needed to transition to an independent physician scientist.

PI_NAMEs: MARKS, BRYNN E (contact)

PROGRAM_OFFICER_NAME: THORNTON, PAMELA L

PROJECT_TERMS: 12 year old;acceptability and feasibility;Acute;Address;Adult;Advisory Committees;assessment application;Behavior;Behavior Therapy;Behavioral;career development;Caring;Child;Child Care;Childhood;Chronic;Clinical;clinical practice;Continuous Glucose Monitor;Controlled Clinical Trials;Data;design;Development;Devices;diabetes educator;diabetes management;Diabetes Mellitus;diabetes self-management;early adolescence;Education;education research;Educational Curriculum;Educational process of instructing;Educational Technology;eligible participant;Endocrinology;Evaluation;experience;Family;Future;glycemic control;Goals;Growth and Development function;health related quality of life;Hemoglobin;improved;improved outcome;Incidence;Individual;innovation;Instruction;Insulin Infusion Systems;Insulin-Dependent Diabetes Mellitus;Intervention;Interview;K-Series Research Career Programs;Knowledge;Knowledge acquisition;Leadership;Learning;Learning Skill;Medical;Medical Education;Mentors;Mentorship;Methodology;motivational enhancement therapy;Multicenter Studies;Needs Assessment;Non-Insulin-Dependent Diabetes Mellitus;novel;Outcome;parental monitoring;Parents;patient oriented;Patients;Persons;Physicians;preadolescence;prevent;Problem Solving;Process;Provider;psychoeducation;psychoeducational intervention;Qualitative Research;Quality of life;Randomized, Controlled Trials;recruit;Research;Research Personnel;research study;Sampling;satisfaction;School-Age Population;Scientist;Semantics;skills;Standardization;Techniques;Technology;Testing;Time;tool;Training;Translating;uptake;Youth

PROJECT_TITLE: Developing a patient-centered psychoeducational tool to realize the potential of diabetes technologies

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


NIH_SPENDING_CATS: Neurosciences;Urologic Diseases

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

PHR: Narrative: Because of our success with peripheral nerve transfer for restoration of function in preclinical animal investigations, we plan to begin human clinical translation very cautiously with a patient population that most closely matches our preclinical canine model which are patients that have lost control of their bladder, bowel and sexual function but retain intact ambulation recruited primarily from patients with sacral chordoma following tumor removal with sacrectomy surgery. The animal studies in this renewal application will parallel the clinical trial studies to further understand the mechanisms of somatic reinnervation for restoration of bladder emptying function. At present there are no satisfactory interventions for patients with an atonic neurogenic bladder that have lost their peripheral parasympathetic nerves to the bladder and restoration of bladder emptying function is expected to greatly improve the quality of life of these patients.

PI_NAMEs: BARBE, MARY F (contact)

PROGRAM_OFFICER_NAME: BAMBRICK, LINDA LOUISE

PROJECT_TERMS: Address;Animal Model;Animals;Anterior;Antibiotic Therapy;awake;Axotomy;Bacteriuria;Behavior;Bladder;Blood Vessels;canine model;Canis familiaris;cell type;Cells;Chordoma;clinical translation;Clinical Trials;Decentralization;Development;effective therapy;Esthesia;Excision;Fiber;Funding;Future;Ganglia;Goals;Growth Factor;Horns;Housing;Human;improved;interstitial;Intervention;Intestines;Investigation;Laboratories;Lesion;Motor;Motor Neurons;Muscle;Neonatal;Nerve;nerve supply;Nerve Transfer;Neural Pathways;Neurogenic Bladder;obturator nerve;Operative Surgical Procedures;Organ;patient population;Patients;Pelvis;Peripheral;Peripheral Nerves;Posture;pre-clinical;Pre-Clinical Model;preclinical study;Property;Quality of life;Recovery;recruit;reinnervation;restoration;Route;Sex Functioning;Side;Smooth Muscle;sphincter ani muscle structure;Spinal;success;Time;Tissue Banks;tumor;Urethra;Urination;Urodynamics;Urothelial Cell;Urothelium

PROJECT_TITLE: Bladder, Urethra and Anal Sphincter Reinnervation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-B(90)]


NIH_SPENDING_CATS: Clinical Research;Diabetes;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Wound Healing and Care

ORG_CITY: WORCESTER

ORG_DEPT: SURGERY

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: PROJECT NARRATIVE Approximately 30% of all diabetics develop a diabetic foot ulcer, resulting in a lower extremity amputation every 30 seconds worldwide because of a life-threatening infection caused by diabetic foot ulcers. An important driver in non- healing diabetic wounds is impairment in the innate immune system; however, there is limited understanding of the mechanism by which diabetes impairs the innate immune system. I aim to identify the mechanisms underlying diabetes-related impaired innate immune dysfunction that prevents wound healing to facilitate the discovery of novel therapeutics that may prevent amputations.

PI_NAMEs: NGUYEN, TAMMY TRAN (contact)

PROGRAM_OFFICER_NAME: LI, YAN

PROJECT_TERMS: Adipocytes;Adipose tissue;Affect;Amputation;Animals;Automobile Driving;Award;Bone Marrow;bone marrow mesenchymal stem cell;CD34 gene;cell type;Cells;Chondrocytes;Coculture Techniques;comparative;cytokine;Data;Development;Diabetes Mellitus;diabetic;Diabetic Foot Ulcer;diabetic patient;diabetic ulcer;disability;Discipline;Emergency Care;Experimental Models;Failure;Flow Cytometry;Funding;Future;Gene Expression;Grant;Harvest;healing;Hematopoiesis;Hematopoietic;Hematopoietic stem cells;Hematopoietic System;Human;human stem cells;Immune;immune function;Immune system;Immune System Diseases;Immunohistochemistry;Immunology;Immunotherapy;Impaired wound healing;Impairment;In Vitro;in vivo;in vivo Model;Infection;Inflammatory;Innate Immune System;Knowledge;Knowledge acquisition;Laboratories;Learning;LEPR gene;Leptin;leptin receptor;Life;lifetime risk;Lower Extremity;Macrophage;Massachusetts;Measures;Mediating;Medical;Medical Care Costs;medical schools;Mentors;Mentorship;Mesenchymal Stem Cells;Metabolic Diseases;Methods;model development;monocyte;mortality;mortality risk;mouse model;Mus;Natural Immunity;neighborhood disadvantage;non-diabetic;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutics;Osteocytes;Patients;Play;Pre-Clinical Model;prevent;Property;receptor expression;Regulatory Pathway;Research;Role;Sample Size;Scientist;Signal Pathway;Signal Transduction;skill acquisition;skills;Stains;stem cell function;stem cell population;stem cells;Surgeon;Systems Development;Techniques;Testing;tissue culture;Tissues;Training;transcriptome sequencing;Translating;Transplantation;Type 2 diabetic;Umbilical Cord Blood;Universities;Western Blotting;Work;wound;wound healing

PROJECT_TITLE: Dissecting the Human Diabetic Bone Marrow Niche


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics;Human Genome;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative While genetics science has revealed many variants in the human genome associated with brain-related diseases such as Alzheimer's or depression, the culprit effector genes (essential to design effective therapies) remain to be discovered. To that end, I propose a “variant-to-gene” mapping campaign leveraging several cutting-edge genomic techniques (including chromatin conformation capture) in human iPSC lines from individuals and patients of different sex and ethnicity. This study will provide targets for drug discovery and begin to address sex and ethnic differences in brain-related diseases, ultimately advancing the goals of precision medicine.

PI_NAMEs: CHESI, ALESSANDRA  (contact)

PROGRAM_OFFICER_NAME: CHADWICK, LISA

PROJECT_TERMS: 3-Dimensional;Address;Alzheimer's Disease;Astrocytes;ATAC-seq;Autopsy;Biological Models;Brain;Brain Mapping;causal variant;Cell Line;cell type;Cells;ChIP-seq;Chromatin;chromosome conformation capture;Chromosome Mapping;Coculture Techniques;Complex;Coupled;Data Set;design;detection method;Development;Dimensions;Disease;drug discovery;Drug Targeting;effective therapy;Enhancers;epigenetic marker;ethnic difference;Ethnic Origin;Etiology;functional genomics;Gene Expression;Gene Expression Regulation;Genes;Genetic Transcription;Genome;genome wide association study;genome-wide;Genomics;Genotype-Tissue Expression Project;Goals;Heterogeneity;Human;Human Genome;Human Genome Project;human induced pluripotent stem cells;in vitro Model;indexing;Individual;Link;Linkage Disequilibrium;Mental Depression;Microglia;Neurodegenerative Disorders;Neurodevelopmental Disorder;Neurons;novel therapeutics;Organoids;Patients;precision medicine;promoter;Quantitative Trait Loci;rare variant;Reporting;Resolution;Sampling;Science of genetics;sex;Sex Differences;Signal Transduction;Techniques;Tissues;tool;trait;transcriptome sequencing;Translating;Untranslated RNA;Variant

PROJECT_TITLE: Variant-to-gene mapping for brain related traits and disorders


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Chronic Pain;Mental Health;Mental Illness;Neurosciences;Pain Research

ORG_CITY: SAINT LOUIS

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

PHR: Project Narrative Psychological stress can either suppress or enhance pain, but we do not understand how. Furthermore, both chronic stress and pain cause adaptations that make anti-depressants effective in treating chronic pain. The goal of this proposal is to better understand how chronic stress modifies the central norepinephrine system to result increased or decreased control of pain.

PI_NAMEs: MCCALL, JORDAN G. (contact)

PROGRAM_OFFICER_NAME: GREENWELL, THOMAS

PROJECT_TERMS: Absence of pain sensation;Acute;acute stress;Affect;Analgesics;Anhedonia;anti-depressive agents;antinociception;Anxiety;Behavior;Brain;Brain Stem;Central Nervous System;Chronic;chronic pain;chronic pain management;Chronic stress;conditional knockout;Data;Electrophysiology (science);emotion regulation;Enzymes;experience;experimental study;Exposure to;Fiber;Genetic;Genetic Models;Goals;Hyperalgesia;in vivo;Individual;inhibitor;Injury;Intervention;Lead;Link;locus ceruleus structure;Mechanics;Mediating;Mental Depression;Mental disorders;Modeling;Modification;Monitor;multidisciplinary;Neurons;neuropsychiatric disorder;Neurosciences;Neurotransmitters;Nociception;noradrenergic;Norepinephrine;norepinephrine system;optogenetics;Pain;Pain Disorder;Pain management;pain processing;patch clamp;Periodicity;Phenotype;Photometry;Physiological Adaptation;prevent;Property;Prosencephalon;Psychological Stress;psychological trauma;Quality of life;Research;response;restraint stress;reuptake;Role;Series;Serotonin;Slice;Social isolation;Spinal;Spinal Cord;Stimulus;Stress;Stressful Event;stressor;Study models;System;Targeted Research;Testing;Translational Research;Work

PROJECT_TITLE: Stress-induced plasticity in noradrenergic analgesia

STUDY_SECTION: SPS

STUDY_SECTION_NAME: Somatosensory and Pain Systems Study Section[SPS]


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Coronaviruses;Emerging Infectious Diseases;Genetics;Infectious Diseases;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Vector-Borne Diseases

ORG_NAME: ROCKEFELLER UNIVERSITY

PHR: Project Narrative Infections by arthropod-borne flaviviruses and respiratory-transmitted coronaviruses are a global detriment to human health with the potential to cause severe epidemics and pandemics. The goal of this project is to characterize the roles of the pan-flavivirus and pan-coronavirus host factors TMEM41B and the closely related protein VMP1 in virus replication and the innate immune response. This work may help to elucidate the druggable potential of both proteins to reduce morbidity and mortality caused by a wide range of flaviviruses and coronaviruses.

PI_NAMEs: RICE, CHARLES M (contact)

PROGRAM_OFFICER_NAME: GAUTAM, RAJEEV

PROJECT_TERMS: 2019-nCoV;Address;Amino Acids;Arbovirus Infections;arthropod-borne;Autophagocytosis;Biological Assay;Cell Lineage;Cells;Cellular biology;combat;conditional knockout;Coronavirus;Coronavirus Infections;CRISPR/Cas technology;Disease Outbreaks;Double-Stranded RNA;Drug Targeting;druggable target;embryonic stem cell;endoplasmic reticulum stress;Enzymes;Epidemic;Event;experimental study;Family;Flavivirus;Flavivirus Infections;Genes;genetic approach;Genome;genome-wide;Goals;Health;Homeostasis;Human;human pluripotent stem cell;immune activation;ineffective therapies;Infection;Innate Immune Response;insight;Integral Membrane Protein;Integration Host Factors;Interferons;Investigation;Knock-out;Knowledge;Life Cycle Stages;lipid metabolism;Lipid Mobilization;Lipids;loss of function;Manuscripts;Membrane;Membrane Proteins;Modeling;Molecular;Morbidity - disease rate;mortality;Mus;mutant;Mutate;mutation screening;Natural Immunity;Organelles;pandemic disease;pathogen;Pathway interactions;Pattern recognition receptor;Pharmaceutical Preparations;Phenotype;Play;Polyproteins;Population;prevent;Proteins;Publishing;recruit;Replication Initiation;Reporting;Resistance;respiratory;response;RNA;RNA replication;RNA Viruses;Role;Series;Signal Transduction;Single Nucleotide Polymorphism;Site;stem cells;Structure;synergism;therapeutic target;Tissues;transcriptome sequencing;Translations;transmission process;Vacuole;Viral;Viral Genome;viral outbreak;viral RNA;Virus;Virus Diseases;Virus Replication;virus testing;Work

PROJECT_TITLE: TMEM41B: a pan-flavivirus and pan-coronavirus host factor with antiviral potential

STUDY_SECTION: VIRB

STUDY_SECTION_NAME: Virology - B Study Section[VIRB]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_NAME: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT

PHR: Narrative: Overall. NMR spectroscopy has important biomedical applications in structural biology, metabolomics, diagnostics, and drug discovery. The burden of managing the complex computing environment required by NMR impacts both developers and end-users, and slows the adoption of emerging methods. The proposed Center for Biomolecular NMR Data Processing and Analysis will develop robust methods to facilitate discovery, dissemination, management, training, and support for the diverse software needed for biomolecular NMR, to enable the application of NMR to more challenging biomolecular systems, and provide software persistence that is essential for reproducible research.

PI_NAMEs: HOCH, JEFFREY C (contact)

PROGRAM_OFFICER_NAME: TAYLOR, VERONICA

PROJECT_TERMS: Address;Adoption;Advisory Committees;Archives;Automobile Driving;Bayesian Analysis;Biological;Biomolecular Nuclear Magnetic Resonance;Communication;Communities;community engagement;Complement;Complex;Computer Assisted;Computer software;computerized data processing;Computers;Data;Data Analyses;data exchange;Data Files;data management;data modeling;data reduction;data submission;Databases;Diagnostic;disease diagnosis;drug discovery;Educational workshop;Electronic Mail;Ensure;Environment;Evaluation;file format;Fostering;Future;Goals;Hour;Infrastructure;innovation;insight;Magnetism;Maintenance;metabolic abnormality assessment;metabolomics;Metadata;Methods;Network Infrastructure;NMR Spectroscopy;novel;Nucleic Acids;Online Systems;operation;Ozone;parallelization;Performance;platform as a service;Play;programs;Protein Dynamics;protein structure;Proteins;recruit;Relaxation;Remote Consultation;Reproducibility;Research;Resources;Role;Running;Sampling;Services;small molecule;solid state nuclear magnetic resonance;Source;Spectrum Analysis;structural biology;Structure;System;Technology;technology development;technology research and development;tool;Training;translational applications;Translations;Update;Validation;virtual;virtual machine;virtual technology;web site

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-T(40)P]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Networking and Information Technology R&D (NITRD)

PROJECT_TERMS: Advisory Committees;Archives;authority;base;Biomolecular Nuclear Magnetic Resonance;Biophysics;Communication;Communities;computer infrastructure;Computer software;computerized data processing;computing resources;Connecticut;Consultations;Counseling;Data Analyses;Databases;Development Plans;Educational workshop;Effectiveness;effectiveness evaluation;Ensure;Face;Feedback;Future;Geography;Infrastructure;Legal;Licensing;Maintenance;Mediation;meetings;member;Molecular Biology;Monitor;Network Infrastructure;Occupational activity of managing finances;Operating System;operation;Participant;Performance;Progress Reports;recruit;Reporting;Research Personnel;Resource Allocation;Resources;Security;Services;Site;software development;software infrastructure;software systems;Suggestion;Surveys;System;Training;United States National Institutes of Health;Universities;Update;web portal;Wisconsin

PROJECT_TITLE: Administration and Management

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-T]