ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Behavioral and Social Science;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

ORG_CITY: CORAL GABLES

ORG_NAME: UNIVERSITY OF MIAMI CORAL GABLES

ORG_STATE: FL

PHR: Narrative Implementation strategies are urgently needed to improve the reach of PrEP and mental health/substance use treatment to Latino men who have sex with men (LMSM) and achieve the Ending the HIV Epidemic goals. This project takes an innovative approach, in which we will characterize, assess, and protocolize existing strategies that HIV organizations are using and create a platform to efficiently scale these strategies up to other LMSM- serving HIV organizations across Ending the HIV Epidemic jurisdictions.

PI_NAMEs: HARKNESS, AUDREY  (contact)

PROGRAM_OFFICER_NAME: POLLARD-BRANCHARD, SUZANNE LEE

PROJECT_TERMS: Address;Adoption;Affect;AIDS prevention;behavior change;Clinical;Collaborations;Communities;dashboard;Disparity;Epidemic;Ethnography;evidence base;Evidence based intervention;experience;Expert Opinion;follow up assessment;Geography;Goals;Grant;HIV;HIV disparities;implementation barriers;implementation determinants;implementation outcomes;implementation research;implementation science;implementation strategy;improved;Incidence;inclusion criteria;Infrastructure;innovation;Intervention;Knowledge;Latino;Link;Maintenance;Maps;Media Campaign;men who have sex with men;Mental Health;Methods;migration;Modeling;novel;Outcome;Pathway interactions;patient navigation;peer;pre-exposure prophylaxis;Procedures;Proctor framework;Protocols documentation;Public Health;Qualifying;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Research;Research Personnel;research to practice;Resources;response;scale up;Self Efficacy;Services;social media;social stigma;Speed;substance use;substance use treatment;Taxonomy;Testing;Trust;usability;user centered design;Work

PROJECT_TITLE: Leveraging a Strategic Alliance of Community-Based Implementers and Researchers to Characterize, Protocolize, and Scale Up Local Implementation Strategies for Ending the HIV Epidemic among Latino MSM


ADMINISTERING_IC: NS

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: NEW YORK

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PHARMACOLOGY

ORG_FIPS: US

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: PROJECT NARRATIVE Pain is a fundamental sensation that is required for alerting organisms to persistent or acute environmental dangers. In this project, we will focus on understanding how the diverse group of neurons, known as nociceptors, are able to initially detect and transmit noxious stimuli from peripheral organs, such as the skin. We will use molecular genetics and functional imaging approaches to perform a cellular and molecular analysis to understand the structure and function of each fundamentally distinct nociceptor subtype.

PI_NAMEs: SHARMA, NIKHIL  (contact)

PROGRAM_OFFICER_NAME: GREENWELL, THOMAS

PROJECT_TERMS: abuse liability;Acute;Afferent Neurons;Anatomy;Animals;Axon;Behavioral;Biophysics;Brain;comparative;Detection;Esthesia;experience;first responder;Functional Imaging;imaging approach;Laboratories;Molecular;Molecular Analysis;Molecular Genetics;neural circuit;Neurons;Nociception;Nociceptors;Opioid Receptor;Organ;Organism;Pain;Pain management;pain perception;pain processing;Peripheral;Pharmacological Treatment;Publishing;Research;Role;single-cell RNA sequencing;Skin;Spinal Cord;Stimulus;Structure;Synapses;Temperature;Therapeutic;tool;transmission process

PROJECT_TITLE: The cellular and molecular mechanisms underlying nociception and pain


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Neurosciences;Precision Medicine

ORG_CITY: ATLANTA

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative Metabolic dysfunction plays a crucial role in disease progression and response to treatment. There are currently very few methods that can non-invasively and repeatedly image metabolism and, as a result, metabolic information is largely absent in clinical decision making. To improve our understanding of the role of metabolism in disease, injury, and recovery, we will develop a new approach for medical imaging termed “metaboloradiomics.”

PI_NAMEs: FLEISCHER, CANDACE C. (contact)

PROGRAM_OFFICER_NAME: UTZ, URSULA

PROJECT_TERMS: Award;Biomedical Engineering;brain health;Chemistry;Clinical;clinical decision-making;Clinical/Radiologic;computerized tools;Data Collection;Development;Diagnosis;Disease;disease prognosis;Disease Progression;high risk;Image;Immersion;improved;Injury;innovation;Left;Magnetic Resonance;Magnetic Resonance Imaging;Magnetic Resonance Spectroscopy;Medical Imaging;Metabolic;Metabolic dysfunction;metabolic imaging;Metabolic Marker;Metabolism;Methods;Mission;Modeling;Morphology;non-invasive imaging;novel;novel strategies;Onset of illness;personalized medicine;Play;Prognosis;Recovery;Research;Research Personnel;Resources;Role;skills;therapy resistant;treatment response;United States National Institutes of Health;Vision

PROJECT_TITLE: A novel framework for quantifying metabolic brain health


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Neurosciences;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: BOSTON

ORG_NAME: DANA-FARBER CANCER INST

ORG_STATE: MA

PHR: Project Narrative Brain tumors have surpassed the leukemias as the leading cause of cancer-related death in children. Therapeutic options for pediatric brain cancers have shown little expansion over the past few decades and the prognosis for many tumor types (especially high-grade gliomas) remains bleak. The research proposed here will identify tumor-associated contacts with the brain microenvironment that guide cellular state transitions, account for tumor grade and can be weaponized to therapeutic ends.

PI_NAMEs: FILBIN, MARIELLA GRUBER (contact)

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: 3-Dimensional;addiction;Architecture;Atlases;Benign;Brain;Brain Neoplasms;brain shape;brain tissue;cancer cell;cancer cell subtype;Cancer Etiology;cancer stem cell;Caring;Cell Communication;Cell division;cell type;Cells;Childhood;Childhood Brain Neoplasm;childhood cancer mortality;Childhood Glioma;Childhood Malignant Brain Tumor;Code;combinatorial;Common Neoplasm;Cues;Data;Data Set;design;Development;Gene Expression;Genetic Transcription;genomic profiling;Glioma;Goals;in situ sequencing;Individual;Invaded;leukemia;Ligands;Localized Malignant Neoplasm;Malignant - descriptor;Methodology;Methods;neoplastic cell;nerve stem cell;Neurons;Normal Cell;Outcome;Patients;Phenotype;Prognosis;receptor;Research;Sampling;Signal Transduction;single-cell RNA sequencing;spatial relationship;Testing;Therapeutic;Tissue Sample;tumor;tumor microenvironment;Visualization;weapons

PROJECT_TITLE: How the 3D Architecture of the Brain Shapes Cancer Cell Fate Decisions


NIH_SPENDING_CATS: Brain Disorders;Emerging Infectious Diseases;Infectious Diseases;Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases;Tuberculosis

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: PROJECT NARRATIVE This project seeks to understand how infection causes inflammation and injury in the brain. This work is relevant to public health because many kinds of infections activate the brain's immune system, which can disrupt blood flow or alter the way neurons communicate with each other. By understanding the basic biology of brain inflammation during infection, we hope to provide needed information to develop treatments that limit brain inflammation, which contributes to the development of many common neurological conditions in humans.

PI_NAMEs: MADIGAN, CRESSIDA ARIANNA (contact)

PROGRAM_OFFICER_NAME: RANGANATHAN, SRIKANTH

PROJECT_TITLE: Bacterial disruption of neuroimmune pathways in a transparent brain


NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Rehabilitation

ORG_DEPT: BIOMEDICAL ENGINEERING

PHR: PUBLIC HEALTH STATEMENT Brain-machine interfaces (BMIs) provide a pathway to restore function for people who are paralyzed, such as those with spinal cord injury or amyotrophic lateral sclerosis. This proposal aims to substantially increase the performance and robustness of BMIs by combining new developments from the field of artificial intelligence with recent advances in our understanding of brain function, with the goal of improving quality of life for people with severe movement disabilities.

PI_NAMEs: PANDARINATH, CHETHAN  (contact)

PROGRAM_OFFICER_NAME: CHEN, DAOFEN

PROJECT_TERMS: Adoption;Amyotrophic Lateral Sclerosis;Area;Artificial Intelligence;Brain;brain machine interface;Calibration;Caregivers;Clinical;Complex;Data;Data Set;Development;disability;Disabling;dynamic system;Elements;functional restoration;Goals;Hybrids;improved;innovation;Intention;Maps;Methods;millisecond;Modeling;Monitor;Monkeys;Motor;Motor Cortex;motor disorder;Movement;neural;neural network;neural prosthesis;Neurons;Neurosciences;next generation;Paralysed;Pathway interactions;Pattern;Performance;Persons;Public Health;Quality of life;Residual state;Self-Help Devices;Spinal cord injury;Testing;Time;virtual;Work

PROJECT_TITLE: Fusing motor neuroscience and artificial intelligence to create next-generation neural prostheses.


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Substance Misuse

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE For the first time in decades, U.S. law makers are considering methadone policy reforms that could significantly change the landscape of opioid use disorder treatment, but uncertainty remains about which changes will lead to the greatest health benefits, while minimizing unintended harms. Using New York State as a case study, we propose to use an agent-based modeling approach to simulate four alternative methadone treatment policy scenarios currently being considered in U.S. policy discussions, and estimate their respective impact on population-level rates of methadone initiation and six-month retention, fatal and non-fatal opioid overdose, and racial/ethnic and urban/rural disparities in these outcomes. Through a unique collaboration between government partners and experts in opioid policy and simulation modeling, and dissemination of findings via a public dashboard and Expert Advisory Board, this work will inform and promote evidence-based policies that can reduce overdose and improve population health.

PI_NAMEs: JORDAN, ASHLY ELIZABETH;KRAWCZYK, NOA  (contact)

PROGRAM_OFFICER_NAME: SU, SHELLEY

PROJECT_TERMS: addiction;Adoption;Affect;American;Calibration;Caring;Case Study;Certification;Collaborations;Communication;Communities;Community Pharmacy;Computer Models;Computer Simulation;Congresses;County;COVID-19 pandemic;dashboard;Data;Developed Countries;Drug abuse;Empirical Research;Ensure;Environment;ethnic minority population;Ethnic Origin;evidence base;Fatality rate;Fentanyl;flexibility;Foundations;Government;Harm Reduction;Health;Health Benefit;Health Services Accessibility;Home;improved;Individual;innovation;Laws;Licensing;Literature;Location;marginalized population;Mathematics;Measures;Medicine;member;Methadone;methadone treatment;Modeling;models and simulation;Nature;New York;Opioid;opioid overdose;opioid policy;opioid treatment program;opioid use disorder;Outcome;outcome disparities;Overdose;overdose death;Overdose reduction;overdose risk;Patients;Persons;Pharmacy facility;Physicians;Policies;Policy Maker;Policy Making;Politics;Population;Population Group;population health;Primary Care;Privatization;programs;Provider;Public Health;Race;racial minority population;racial prejudice;randomized trial;Recording of previous events;Regulation;Research;Research Personnel;rural area;rural disparities;Services;simulation;social stigma;Societies;Specialist;State Government;Stigmatization;System;Testing;Time;Translations;Uncertainty;Work

PROJECT_TITLE: Simulating the Impact of Office-Based Methadone Prescribing and Pharmacy Dispensing on OUD Treatment and Overdose in New York State: An Agent-Based Modeling Approach

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 SUY-E (M1)]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: GLASSBORO

ORG_DEPT: CHEMISTRY

ORG_NAME: ROWAN UNIVERSITY

ORG_STATE: NJ

PHR: Project Narrative Diazepines are among the most important families of pharmacologically relevant molecular scaffolds and their properties extend from anti-inflammatory to anti-microbial, analgesic, anti-viral, anti-fungal, analgesic, anti- psychotic, anxiolytic, and anti-histaminic. Among these: benzodiazepines are especially relevant due to their sedative, hypnotic, anxiolytic, anti-convulsing and muscle relaxant properties. This proposal will develop a novel enantioselective method for the synthesis of diazepines and benzodiazepines from simple and accessible diaziridines.

PI_NAMEs: MOURA-LETTS, GUSTAVO  (contact)

PROGRAM_OFFICER_NAME: FABIAN, MILES

PROJECT_TITLE: Rearrangement Reactions of Divinyldiaziridines for the Enantioselective Synthesis of Diazepines and Benzodiazepines - Supplemental for Equipment Purchase


NIH_SPENDING_CATS: Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Neurosciences;Prevention;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: CHARLESTON

ORG_DEPT: PSYCHIATRY

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: PROJECT NARRATIVE Cigarette smoking is a significant public health concern. Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive form of brain stimulation that has already displayed remarkable potential for producing novel, non-pharmacological interventions for neuropsychiatric disorders. Here we will develop a brain circuit-based precision rTMS therapy for smoking cessation.

PI_NAMEs: LI, XINGBAO  (contact)

PROGRAM_OFFICER_NAME: WANG, JIA BEI

PROJECT_TERMS: Abstinence;active method;Active Sites;Aftercare;Automobile Driving;blood oxygen level dependent;Brain;Cigarette;cigarette smoking;Clinical;clinical effect;Clinical Trials;Cognitive Therapy;comparative efficacy;Consumption;craving;Cues;Double-Blind Method;executive function;follow-up;Frequencies;frontal lobe;Functional Magnetic Resonance Imaging;functional MRI scan;Goals;improved;innovation;Left;Magnetic Resonance Imaging;Measures;Medial;Modeling;neuronal circuitry;neuropsychiatric disorder;neuroregulation;Nonpharmacologic Therapy;novel;Nucleus Accumbens;Outcome;Outcome Measure;Participant;Pharmaceutical Preparations;Pharmacotherapy;Phase;Physiologic pulse;placebo group;Prefrontal Cortex;Public Health;Randomized;recruit;repetitive transcranial magnetic stimulation;Reporting;response;Rewards;Signal Transduction;Smoke;Smoker;smoking cessation;smoking cue;Smoking treatment;Testing;Therapeutic;Therapeutic Effect;therapeutic evaluation;tobacco abstinence;Tobacco Use Disorder

PROJECT_TITLE: RTMS manipulates imbalanced drive-reward and executive control circuitry for smoking cessation


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Back Pain;Bioengineering;Chronic Pain;Disability Research;Genetics;Pain Research;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_DEPT: ORTHOPEDICS

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: NARRATIVE Intervertebral disc (IVD) degeneration is a major contributor to back pain and disability with a lack of effective treatment strategies, and the poor IVD healing capacity requires new ways of thinking. This project uses a novel IVD regenerative healing model and innovative genetic and microscopy tools to identify cells and extracellular matrix microenvironment factors critical for enabling IVD healing and regeneration. Next, design criteria for cell delivery are identified and validated on human cells and tissues.

PI_NAMEs: IATRIDIS, JAMES C. (contact)

PROGRAM_OFFICER_NAME: MARQUITZ, ARON

PROJECT_TERMS: Adult;Affect;Age;Aging;Anatomy;Atomic Force Microscopy;Back Pain;beta Aminopropionitrile;Biomechanics;Cell Maturation;Cell Proliferation;cell regeneration;Cell Therapy;Cells;Chronic;Clinical Trials;Collagen;crosslink;Data;Defect;density;Deposition;design;Diameter;disability;disability impact;discogenic pain;effective therapy;Engineering;Environment;ethylene glycol;Extracellular Matrix;Fibrosis;Functional disorder;Genetic;Growth;healing;Height;Human;improved;Inflammation;inhibitor;Injections;Injury;innovation;Integrins;Intervertebral disc structure;intervertebral disk degeneration;Ligands;Mechanics;Mediating;Microscopy;Mitosis;Modeling;Modulus;mouse model;Mus;nanoindentation;Natural regeneration;Neonatal;neonate;Nerve;neurovascular;novel;nucleus pulposus;old mice;Outcome;Pain;permissiveness;Phenotype;Play;Population;Population Heterogeneity;postmitotic;postnatal;Process;progenitor;Proliferating;Property;Protein-Lysine 6-Oxidase;Puncture procedure;recruit;Recurrence;regeneration potential;regenerative;Regenerative capacity;regenerative healing;Regenerative Medicine;regenerative repair;repair strategy;restoration;Role;scleraxis;single-cell RNA sequencing;standard care;stem cell population;Thinking;Time;Tissue Engineering;Tissues;tool;transcriptome sequencing;treatment strategy

PROJECT_TITLE: Mechanisms for Regenerative Healing in Intervertebral Discs

STUDY_SECTION: MTE

STUDY_SECTION_NAME: Musculoskeletal Tissue Engineering Study Section[MTE]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Depression;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Mental Illness;Physical Injury - Accidents and Adverse Effects;Post-Traumatic Stress Disorder (PTSD);Prevention;Social Determinants of Health;Violence Research

ORG_CITY: SAN DIEGO

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: SAN DIEGO STATE UNIVERSITY

PHR: PROJECT NARRATIVE HIV pre-exposure prophylaxis (PrEP) is an evidence-based innovation and part of the EHE ‘Prevent’ pillar for individuals with an elevated risk for HIV exposure such as transgender and gender diverse/expansive (TGD) individuals, but uptake of PrEP remains low, especially among TGD individuals affected by violence and trauma. Currently, there is high need to identify and test multilevel implementation strategies that improve mental health and address structural barriers to improve and accelerate PrEP uptake and persistence among TGD individuals. Our uniquely qualified community-academic collaborative research team proposes to assess the acceptability, feasibility, appropriateness, and preliminary effects of integrating an evidence-based mental health treatment into an ongoing gender-affirming PrEP implementation project for TGD community members affected by violence, trauma, and HIV.

PI_NAMEs: STORHOLM, ERIK D. (contact)

PROGRAM_OFFICER_NAME: SENN, THERESA ELAINE

PROJECT_TERMS: Acceleration;Address;Adherence;Adoption;Affect;AIDS prevention;alcohol and other drug;Alcohol consumption;Alcohols;Behavioral;California;Chronic;Client;Cognitive;Communities;community center;community partnership;comorbidity;Complex;coping;County;Data;depressive symptoms;Diagnostic;Drug usage;effectiveness/implementation hybrid;efficacy testing;Eligibility Determination;emotion regulation;Employment;Epidemic;ethnic diversity;evidence base;Evidence based treatment;experience;Financial Hardship;flexibility;follow-up;Funding;gender affirmation;gender diverse;HIV;HIV risk;HIV/AIDS;Housing;housing instability;implantation;implementation barriers;implementation evaluation;implementation framework;implementation process;implementation science;implementation strategy;improved;Individual;innovation;Interpersonal Relations;Intervention;Interview;Knowledge;Legal;Link;Los Angeles;Mediating;Medical;member;Mental Depression;Mental Health;Mental Health Associations;minority stressor;Multiple Trauma;Parents;Participant;peer;people of color;Persons;Phase;pilot trial;Post-Traumatic Stress Disorders;pre-exposure prophylaxis;Prevalence;prevent epidemics;preventive intervention;Primary Care;programs;Provider;Qualifying;racial diversity;Randomized;Randomized, Controlled Trials;Regulation;Reporting;Research;Resources;Risk;scale up;service organization;Services;Site;skills training;social;Specific qualifier value;Subgroup;substance use;suicidal;Surveys;Symptoms;syndemic;Testing;transgender;Trauma;traumatic event;Treatment Efficacy;uptake;Violence;violence exposure;violence prevention;violence victimization;Wellness Center;Work

PROJECT_TITLE: Implementing an Evidence-Based Trauma Treatment with Community-led PrEP Navigation for Transgender and Gender Diverse Individuals Affected by Violence and HIV.

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


ADMINISTERING_IC: DK

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Digestive Diseases;Inflammatory Bowel Disease;Nutrition

ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Project Narrative Glutathione peroxidase 1 (GPx1) is one of the most widely expressed antioxidant proteins in the body, yet its role in the intestine is largely unknown. Interestingly, while antioxidant proteins are mostly thought to protect the intestine in the setting of inflammatory bowel disease and colitis-associated cancer, my preliminary data shows that mice without GPx1 are protected from colitis. This proposal will define the role of GPx1 in intestinal epithelial and immune cells, test GPx1-dependent effects on colitis and colitis-associated carcinoma, and evaluate whether GPx1 can serve as a therapeutic target in the setting of gastrointestinal disease.

PI_NAMEs: SHORT, SARAH PALMER (contact)

PROGRAM_OFFICER_NAME: SASLOWSKY, DAVID E

PROJECT_TERMS: 3-Dimensional;Active Sites;Adenocarcinoma;Affect;Amino Acids;Animal Model;Antioxidants;Attenuated;Bone Marrow;Bone Marrow Transplantation;Carcinoma;career;career development;Cell Culture Techniques;Cell Physiology;Cells;Cellular biology;chemokine;cohort;Colitis;colitis associated cancer;Complement;Crohn's disease;Cytoplasm;Data;Development;dextran sulfate sodium induced colitis;disorder risk;Doctor of Philosophy;Dysplasia;Ensure;Epidemiology;Epithelial Cells;epithelial injury;Epithelium;experience;experimental study;FDA approved;Flow Cytometry;Gastroenterology;Gastrointestinal Diseases;glutathione peroxidase;Goals;GPX2 gene;Hematopoietic;Homeostasis;Hydrogen Peroxide;Ileocolitis;Immune;Immune response;Immunological Models;Immunology;improved;In Vitro;in vivo;Inflammation;Inflammatory;Inflammatory Bowel Diseases;Injury;Institution;Intestinal Diseases;intestinal epithelium;intestinal homeostasis;intestinal injury;Intestines;Macrophage;Malignant Neoplasms;Mediating;Medicine;Mentors;Metabolism;Micronutrients;Mitochondria;Modeling;Mucous Membrane;murine colitis;Mus;Organoids;Oxidation-Reduction;Oxidative Stress;Patients;programs;protective effect;Proteins;recruit;Reduced Glutathione;regenerative healing;Regulation;Research;Research Activity;Research Personnel;response;response to injury;Role;Selenium;selenium deficiency;Selenocysteine;selenoenzyme;selenoprotein;Severities;Severity of illness;Single Nucleotide Polymorphism;Sodium Dextran Sulfate;stem cell function;stem cells;stemness;Stimulus;T-Lymphocyte;Testing;Therapeutic;therapeutic target;therapeutically effective;timeline;tissue/cell culture;Training;Ulcerative Colitis;Work;wound healing

PROJECT_TITLE: Antioxidant regulation of intestinal homeostasis and disease


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Hematology

ORG_CITY: RICHMOND

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: PROJECT NARRATIVE  Although several anticoagulants including heparins, warfarin, and direct oral anticoagulants are used in the clinic today, each suffers from major and minor bleeding adverse effects. The current proposal focuses on studying a library of 20 rationally designed analogs of a promising allosteric inhibitor of human factor XIa with the goal of identifying at least one lead agent devoid of enhanced bleeding risk for advanced stage pre-clinical development.

PI_NAMEs: DESAI, UMESH RAMANLAL (contact)

PROGRAM_OFFICER_NAME: WARREN, RONALD Q

PROJECT_TERMS: Active Sites;Adverse effects;Affinity;analog;Animals;Anticoagulant therapy;Anticoagulants;Anticoagulation;Area;Binding;Biological;Biotechnology;Chemistry;Clinic;Clinical;Clinical Research;Coagulation Process;cost;COVID-19;Cues;design;Disease;Dose;Drug Costs;drug development;Drug Interactions;Drug Kinetics;drug metabolism;drug standard;Drug usage;Elements;Enoxaparin;enzyme activity;Enzyme Inhibition;Enzymes;experience;Factor XIa;Fibrinolytic Agents;Goals;Health;Hemorrhage;Heparin;Heparin Binding;Human;improved;In Vitro;in vivo;Incubators;inhibitor;Inositol;Institution;interest;Lead;Leadership;Legal patent;Libraries;Location;Malignant Neoplasms;manufacture;Measures;Minor;Myocardial Infarction;Names;National Heart, Lung, and Blood Institute;New Agents;novel;Oral;Outpatients;Pathway interactions;Peptide Hydrolases;Pharmaceutical Preparations;Pharmacodynamics;pharmacokinetics and pharmacodynamics;Phase;Plasma;Population Characteristics;Positioning Attribute;preclinical development;preclinical study;Preparation;Property;rational design;Rattus;Renal clearance function;Research Project Grants;Risk;Role;scaffold;scale up;screening;Self Administration;small molecule;Stereoisomer;Stroke;Structure;Sulfate;Tail;Technology;Therapeutic;Thrombosis;thrombotic;Toxic effect;Unstable angina;Venous Thrombosis;Warfarin

PROJECT_TITLE: Lead identification and pre-clinical studies on allosteric inhibitors of coagulation factor XIa


ADMINISTERING_IC: DC

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

ORG_CITY: JACKSONVILLE

ORG_NAME: TURNER SCIENTIFIC, LLC

ORG_STATE: IL

PHR: Project Narrative The minipig has an inner ear of comparable size and shape to the human making it an ideal model for translating experimental drug therapies and implantable devices to the human. We will characterize the pharmacokinetics of the minipig ear, collect objective measures of hearing, and generate noise damage models for the evaluation of protective drug therapies in minipigs. Establishing the minipig as the premier large-animal model for hearing research will save countless thousands of research dollars which would otherwise be spent on drugs that cannot be delivered effectively to target tissues in the mid and apical regions of the cochlea.

PI_NAMEs: HENTON, AMANDA M;SALT, ALEC N;TURNER, JEREMY G (contact)

PROGRAM_OFFICER_NAME: MILLER, ROGER

PROJECT_TERMS: Acquired Deafness;Acute;Affect;Air;Anesthetics;Animal Model;Animals;Apical;Area;Auditory;Bankruptcy;Behavior;Biological Products;Biomedical Research;Biotechnology;Bone Conduction;Calibration;Cavia;childhood hearing loss;Chronic;cisplatin induced hearing loss;Clinical Trials;Cochlea;Communities;Complex;Computer Models;Computer Simulation;cost;Data;Data Set;design;Detection;Development;Device or Instrument Development;Devices;Dexamethasone;Dimensions;Disasters;disease model;Drug Delivery Systems;drug development;drug distribution;drug efficacy;Drug Implants;Drug Kinetics;Drug Modelings;Ear;efficacy study;efficacy testing;Ethics;Evaluation;External auditory canal;Face;Failure;Family suidae;FDA approved;fluorescein isothiocyanate dextran;Formulation;Frequencies;Goals;Grant;Hair Cells;Hearing;hearing impairment;Hearing problem;hearing restoration;Human;Hyperacusis;Image;Impairment;implantable device;Industry;inner ear development;Investments;Labyrinth;Length;Light;Liquid substance;Measurement;Measures;medication safety;Membrane;Methods;middle ear;Miniature Swine;Modeling;Modiolus;Noise;Noise-Induced Hearing Loss;nonhuman primate;optical imaging;ototoxicity;Pathology;Pathway interactions;Perilymph;Persons;Pharmaceutical Preparations;Pharmacologic Substance;Pharmacotherapy;preclinical study;predictive modeling;Presbycusis;prevent;Privatization;Procedures;Property;Protective Agents;Research;research and development;Research Contracts;Residencies;Resources;Rodent;round window;safety testing;Sampling;Shapes;simulation;small molecule;Sodium Chloride;sound;Source;standard measure;Stimulus;System;Testing;Therapeutic;Therapeutic Effect;Thinness;Three-Dimensional Imaging;Time;Tinnitus;Tissues;touchscreen;Training;Translating;Treatment Failure;Universities;Validation;valproate;Vision;Work

PROJECT_TITLE: Minipig Model Validation for Hearing Research and Drug and Device Development

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-M (12)]


NIH_SPENDING_CATS: Adolescent Sexual Activity;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Contraception/Reproduction;Dissemination and Implementation Research;HIV/AIDS;Health Services;Infectious Diseases;Mental Health;Pediatric;Pediatric - AIDS;Prevention;Women's Health Research

ORG_CITY: SAN FRANCISCO

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: NARRATIVE New and innovative strategies are urgently needed to increase the uptake of HIV prevention and sexual and reproductive health services among adolescent girls and young women (AGYW) in sub-Saharan Africa. To ensure the real-world sustainability of our demand-generating intervention for AGYW delivered by private drug shops, we will rigorously test supply-side subsidy structures for shopkeepers’ provision of HIV-self testing kits and contraceptives to AGYW combined with prosocial motivational supports. Our combination of non-monetary and monetary support structures aims to emulate real-world health financing models for public-private partnerships and ultimately aims to improve equity in access to critical prevention services for AGYW at scale.

PI_NAMEs: LIU, JENNY XIN (contact)

PROJECT_TERMS: Adoption;Africa South of the Sahara;Age;AIDS prevention;arm;Attitude;barrier to care;behavior change;Behavioral;behavioral economics;Businesses;Caring;Client;Communities;Contraceptive Agents;Contraceptive Distributions;Contraceptive methods;cost;Costs and Benefits;Data;design;Diagnostic Reagent Kits;drug structure;Economics;Educational workshop;Effectiveness;effectiveness evaluation;effectiveness trial;effectiveness/implementation trial;Ego;Elements;Enrollment;Ensure;Equity;Face;Female Adolescents;financial incentive;Friends;Future;girls;Goals;Government;Health;Health behavior;Health care facility;health care service;Health financing;Health Personnel;Health Services;Health system;HIV;HIV Infections;human centered design;Human immunodeficiency virus test;implementation evaluation;implementation science;improved;Incentives;Infrastructure;Injectable;innovation;interest;Intervention;intervention program;Interview;Learning;Liquid substance;Maintenance;Marketing;Methods;Modeling;Motivation;operation;Oral;Pathway interactions;Periodicals;Personal Satisfaction;Pharmaceutical Preparations;Pharmacy facility;Phase;pill;Population;Positioning Attribute;pre-exposure prophylaxis;Prevention;prevention service;Preventive;Preventive Health Services;Preventive service;Price;Private Sector;Privatization;Process;programs;Protocols documentation;public health intervention;public-private partnership;Randomized;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Records;Reproducibility;Reproductive Health Services;Research;Research Support;Rest;Sales;scale up;self testing;Services;sexual and reproductive health;Side;Signal Transduction;social;Structure;success;successful intervention;Surveys;Tanzania;Testing;theories;unintended pregnancy;uptake;Vendor;Visit;ward;Women's Health;World Health;young woman;Youth

PROJECT_TITLE: AmbassADDOrs for Health: Maintaining youth-friendly HIV prevention services to young women through drug vendors

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Scalable interventions that facilitate adherence to HIV pre-exposure prophylaxis (PrEP) are urgently needed to address the alarming racial inequity in HIV incidence among Black men who have sex with men. This study combines two evidence-based interventions into an innovative integrated strategy to advance impact-focused HIV prevention science by reducing interpersonal and structural stigmas to increase PrEP adherence, which is a scientific priority of NIMH. The findings from this research will also enhance scale-up potential by identifying the key elements of the integrated strategy that contributes most to PrEP adherence and thus should be strengthened, elements that contribute least and can be streamlined, as well as the market economic, social, and political variables that must be manipulated to accelerate its implementation at scale and achieve equitable PrEP impact—a national End the HIV Epidemic priority.

PI_NAMEs: NELSON, LARON EARNEST;RAMOS, SILVIA RAQUEL  (contact);WILTON, LEO

PROJECT_TERMS: Acceleration;Accounting;Address;Adherence;Affect;AIDS prevention;Area;arm;Behavior;Behavior assessment;Behavior Therapy;Behavioral;behavioral outcome;black men;black men who have sex with men;Black race;Blood;Businesses;care coordination;Caring;Cities;Client;Communities;Complex;cost;Data;design;Diagnosis;dosage;Dose;Dryness;Economics;Ecosystem;efficacy evaluation;efficacy/implementation trial;Elements;Epidemic;Equation;Equity;Evidence based intervention;Exposure to;follow-up;Frequencies;Gender;Goals;Health;Health Care Seeking Behavior;health equity;Health Insurance;Health Services Accessibility;Healthcare;HIV;HIV diagnosis;HIV Infections;HIV risk;HIV Seronegativity;Hybrids;implementation framework;improved;Incentives;Incidence;innovation;Institution;Institutional Policy;Intervention;Interview;Learning;Length;Lesbian Gay Bisexual Transgender;Link;Marketing;men;men who have sex with men;Methodology;Methods;Modeling;National Institute of Mental Health;novel;Phase;Policies;Politics;pre-exposure prophylaxis;Prevalence;Prevention;Process;public health intervention;racial disparity;Racial Equity;Randomized;randomized trial;Recommendation;recruit;Research;Risk Behaviors;Risk Reduction;scale up;Science;Self Determination;Serum;service delivery;Service delivery model;service engagement;service providers;Services;social;social stigma;Specific qualifier value;Spottings;standard of care;Supportive care;Surveys;System;theories;Therapeutic;Thinking;Time;Training;Transportation;United States;Voice;welfare

PROJECT_TITLE: A Multi-Level Integrated Strategy to Optimize PrEP Adherence for Black MSM and Accelerate Implementation at Scale

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CCHI-K (02)]


ADMINISTERING_IC: NR

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: EAST LANSING

ORG_NAME: HENRY FORD HEALTH + MICHIGAN STATE UNIVERSITY HEALTH SCIENCES

ORG_STATE: MI

PHR: PROJECT NARRATIVE The N-PATHS (Nursing Program for Advancing Training in Health and Social Determinants) program is envisioned as a research training program to enrich nurse scientists' understanding and application of social determinants of health into research. This program aims to enhance knowledge, integrate SDOH into nursing research, and translate findings into practice and policy, thereby contributing to the improvement of equity for all. This comprehensive and immersive program includes in-person networking, didactic lectures, webinars, community engagement, and mentorship with the goal of nurturing skills in SDOH research design, analysis, and dissemination.

PI_NAMEs: VANCE, ASHLEE JONES (contact)

PROGRAM_OFFICER_NAME: BLACHMAN, DARA

PROJECT_TERMS: Address;Advisory Committees;Ally;career development;Caring;Collaborations;Communication;Communities;community engagement;Complex;Continuity of Patient Care;curriculum development;Data Collection;Democracy;design;Discipline;Discipline of Nursing;disparity elimination;Disparity population;Education;Educational Curriculum;empowerment;Encapsulated;Equity;experience;Faculty;Feedback;Fostering;Foundations;Future;Goals;Health;Health Care Costs;health determinants;health equity;Health equity research;health inequalities;health outcome disparity;health training;Healthcare;holistic approach;implementation science;improved;Individual;insight;interest;Knowledge;Knowledge acquisition;Lead;Leadership;Learning;learning materials;Learning Module;lectures;Life Expectancy;Measures;Medicine;Mental Health;Mentors;Mentorship;Methodology;Modeling;multidisciplinary;National Institute of Nursing Research;Nature;Nurse's Role;Nurses;Nursing Research;Outcome;Participant;patient population;Patient Recruitments;Patients;Persons;physical conditioning;Policies;Positioning Attribute;Process;programs;Psychology;Publishing;Reporting;Research;research and development;Research Design;Research Methodology;Research Personnel;Research Training;Resources;response;Role;Science;Scientist;Shapes;skill acquisition;skills;social;social determinants;social health determinants;Strategic Planning;Strategic vision;theories;timeline;Training;Training Programs;Translating;United States;web site;webinar;website development;Work;World Health Organization

PROJECT_TITLE: A Nursing Program for Advancing Training in Health and Social Determinants (N-PATHS)

STUDY_SECTION_NAME: Special Emphasis Panel[ZNR1 REV-N (06)]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Dissemination and Implementation Research;Health Services;Mental Health;Pediatric;Primary Health Care

ORG_CITY: ARLINGTON

ORG_NAME: SAPIEN HEALTH LLC

PHR: NARRATIVE Sapien Health has developed the pediatric Mental Health Quotient – 10 (MHQ-10) mental health triage tool and the Clinical Mental Health Quotient (cMHQ), which, through a single compact assessment, captures a comprehensive symptom profile, positive/protective life factors, lifestyle, life traumas and adversities to generate a vetted clinician report that includes a score of their aggregate mental wellbeing and guidance to the clinician that enhance opportunities for preventative care and effective choice of treatment. Successful implementation of any new assessment within a hospital or clinic depends crucially on how it is embedded in the workflow and the consequent patient and clinician experience such as when and how patients are presented the assessment, how they are encouraged to complete the assessments, when and how doctors are presented the reports, and how they are guided to use the reports during the appointment. In this Phase II SBIR we will use an innovative, participatory implementation research method of co-design (brainwriting premortem) to develop a powerful workflow for integration of the pediatric MHQ suite within primary care and behavioral healthcare at Rady Children’s Hospital San Diego and evaluate its feasibility, acceptability and perceived patient and clinician benefits.

PI_NAMEs: STADNICK, NICOLE A;THIAGARAJAN, TARA  (contact)

PROGRAM_OFFICER_NAME: HAIM, ADAM J

PROJECT_TERMS: Address;Adolescent;adolescent patient;Adoption;Adult;Appointment;Assessment tool;behavioral health;Child health care;Child Mental Health;Childhood;Clinic;Clinical;Clinics and Hospitals;Collaborations;commercialization;design;Development;Diagnosis;Diagnostic;Dimensions;Disease;Effectiveness;effectiveness/implementation trial;Electronic Health Record;experience;feasibility testing;Feedback;flexibility;Health;health assessment;Healthcare;implementation evaluation;implementation protocol;implementation research;implementation science;Individual;Informatics;innovation;insight;instrument;Intervention;Interview;Life;Life Style;Maintenance;Maps;Medical Staff;Mental disorders;Mental Health;Mental Health Services;Methods;Monitor;novel;Outcome;Patients;Pediatric Hospitals;personalized screening;Persons;Phase;Physicians;Positioning Attribute;pre-clinical;Preventive care;Primary Care;primary care clinic;Psyche structure;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;Reporting;Research;research clinical testing;Research Methodology;response;Services;Silicon Dioxide;Small Business Innovation Research Grant;success;Symptoms;Testing;tool;Training;Trauma;treatment choice;Triage;Well in self;Work

PROJECT_TITLE: Integration and Evaluation of the cMHQ, a Novel Transdiagnostic Mental Assessment in Clinical Pediatric Practice

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 HSS-J (10)]


FUNDING_MECHANISM: RESEARCH CENTERS

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Building Research Capacity at Institutions with Limited NIH Funding;Emerging Infectious Diseases;Infectious Diseases;Rare Diseases;Vector-Borne Diseases

ORG_CITY: GRAND FORKS

ORG_NAME: UNIVERSITY OF NORTH DAKOTA

ORG_STATE: ND

PI_NAMEs: BRISSETTE, CATHERINE AYN;NILLES, MATTHEW L. (contact)

PROGRAM_OFFICER_NAME: CUPIT, PAULINE

PROJECT_TERMS: Age;Anti-Inflammatory Agents;Bacteria;biodefense;Bubonic Plague;Cellular Infiltration;Containment;Disease;draining lymph node;Emerging Communicable Diseases;Endemic Diseases;Evolution;Exposure to;extracellular;Genome;Genomics;Immunosuppression;Infection;Infiltration;Inflammation;Inflammatory;Inflammatory Response;insight;Knowledge;Lung;Macrophage;Modeling;mouse model;Necrosis;neutrophil;Neutrophil Infiltration;nonhuman primate;North America;Pasteurella pseudotuberculosis;pathogen;Pathogenesis;Pathogenicity;Phase;Plague;Pneumonic Plague;prevent;Primates;Rattus;Research;Resources;Role;Signal Pathway;Site;South America;Type III Secretion System Pathway;Virulence Factors;Yersinia;Yersinia pestis

PROJECT_TITLE: Yersina perstis interactions with macrophages


ADMINISTERING_IC: AG

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences;Prevention

ORG_DEPT: NEUROSCIENCES

PHR: Project Narrative Alzheimer’s disease (AD) is a highly heritable disease characterized by progressive cognitive decline, and large-scale genetic approaches have been adopted to study the etiology of the disease. This proposal will harmonize genomic and transcriptomic data to understand how genetic variants alter adenosine-to-inosine (A- to-I) RNA editing, a post-transcriptional modification observably dysregulated in AD patient tissues. Understanding how AD-associated genetic variants modulate pre- and post-transcriptional processes will illuminate genes and pathways which can be therapeutically targeted to restore cellular function, or considered as biomarkers to support early detection of AD.

PI_NAMEs: CUDDLESTON, WINSTON HIRSCHLER (contact)

PROGRAM_OFFICER_NAME: MARTIN, DAMALI

PROJECT_TERMS: Adenosine;Adopted;Adult;Affect;Alzheimer disease detection;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease risk;Alzheimer’s disease biomarker;Amino Acid Sequence;Applied Genetics;Autopsy;Award;base;Binding;Biological;Biological Markers;biomarker development;Blood;Brain;brain cell;Brain region;brain tissue;Catalogs;causal variant;Cell Lineage;Cell Physiology;cell type;Cells;Central Nervous System;Chromosome Mapping;Code;cohort;Collection;Complex;Data;Disease;Disease Progression;disorder risk;DNA;Early Diagnosis;Etiology;Event;extracellular;follow-up;Foundations;Functional disorder;Future;Gene Expression;gene function;Genes;Genetic;genetic approach;genetic architecture;genetic association;Genetic Predisposition to Disease;Genetic Risk;genetic variant;Genetic Variation;Genome Mappings;genome wide association study;genome-wide;genomic data;Genomics;Genotype;Heritability;Histopathology;Homeostasis;Human;Impaired cognition;improved;Inflammatory;Inosine;Interferons;Maps;Mediating;Mediation;Meta-Analysis;Methodology;Methods;Microglia;MicroRNAs;Modification;Molecular;molecular phenotype;monocyte;Myelogenous;Myeloid Cells;Natural Immunity;Neurodegenerative Disorders;Neuroimmunomodulation;neuroinflammation;novel;Open Reading Frames;Outcome;Pathway interactions;Patients;Peripheral;Phenotype;pleiotropism;Population;posttranscriptional;Quality of life;Quantitative Trait Loci;Regulation;Regulatory Element;Regulatory Pathway;Reporting;Resolution;Resources;response;Risk;risk variant;RNA;RNA Editing;RNA Splicing;Role;Senile Plaques;Signal Transduction;Site;Solid;Sorting;Specificity;Statistical Methods;Susceptibility Gene;Symptoms;targeted treatment;tau aggregation;Testing;Therapeutic;therapeutic development;therapeutic RNA;therapeutic target;Tissues;trait;Transcript;Transcription Process;transcriptome sequencing;transcriptomics;United States;Untranslated RNA;validation studies;Variant;Work

PROJECT_TITLE: Examining the genetic regulation of A-to-I editing and mediation of Alzheimer's disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F08-A(20)L]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Clinical Research

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE (RELEVANCE STATEMENT) – OVERALL The Duke Cancer Institute, which has authority and responsibility for all cancer-related activities at Duke University and in the Duke University Health System, provides support and promotes collaborations between faculty and staff involved in cancer research, education, and patient care. This Cancer Center Support Grant facilitates oversight and integration of all cancer-related research activities, from basic research to translational studies to clinical and population investigation to community outreach to global cancer. Building upon an extensive strategic planning process, priority activities to maximize local, regional, and national impact have been identified.

PI_NAMEs: KASTAN, MICHAEL B (contact)

PROGRAM_OFFICER_NAME: HE, MIN

PROJECT_TERMS: Achievement;anti-cancer research;Arts;authority;Award;Basic Science;Businesses;Cancer Burden;cancer care;Cancer Center Support Grant;cancer genomics;Cancer Patient;Cancer Science;career development;Caring;Catchment Area;Clinical;clinical care;Clinical Research;Clinical Trials;Collaborations;Communication;Communities;community engagement;Community Health;Community Outreach;Complex;cost;design;Development;Direct Costs;Discipline of Nursing;Duke Comprehensive Cancer Center;Education;Engineering;Enrollment;Environment;Faculty;Faculty Recruitment;Fellowship;Funding;Future;Goals;Grant;Health;health disparity;Health system;Infrastructure;innovation;Interdisciplinary Study;Intervention;Investigation;Investments;Laboratories;Leadership;Link;Malignant Neoplasms;medical schools;Medicine;member;Mission;multidisciplinary;new technology;next generation;novel;Oncology;outpatient facility;Paper;Patient Care;Patients;Peer Review;Pilot Projects;Population;population based;Population Research;Population Sciences;Process;programs;Public Policy;Publishing;Recommendation;recruit;Research;Research Activity;Research Infrastructure;Research Personnel;Research Technics;Resource Allocation;Resource Sharing;Schools;Science;Scientist;Series;Signal Transduction;Strategic Planning;Structure;Testing;Therapeutic;therapeutic development;therapeutic evaluation;Time;Training;Training and Education;training opportunity;Translational Research;translational study;Translations;Universities;University Hospitals;Work

PROJECT_TITLE: Cancer Center Support Grant

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


ED_INST_TYPE: SCHOOLS OF EDUCATION

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Networking and Information Technology R&D (NITRD);Nutrition;Prevention

ORG_CITY: HONOLULU

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF HAWAII AT MANOA

ORG_STATE: HI

PHR: PROJECT NARRATIVE Elevating dietary assessment through harnessing the capabilities of computers, mobile-based, and image- based technology tools which offer an opportunity to reach a wide audience via cost-effective, convenient, timely, and familiar channels.

PI_NAMEs: DELP, EDWARD J;MCCRORY, MEGAN A;WILKENS, LYNNE R (contact)

PROGRAM_OFFICER_NAME: REEDY, JILL

PROJECT_TERMS: Age;All of Us Research Program;Area;Assessment tool;Attention;Attenuated;Automation;Behavior;Behavior Therapy;Big Data Methods;Biomarker of Dietary Intake;Characteristics;Chronic Disease;clinical center;Code;Cognition;Communities;comparative;Computers;Consumer Preferences;Controlled Study;cost;cost effective;Data;Data Analytics;Data Collection;data ecosystem;data exchange;data management;Data Security;Data Storage and Retrieval;decision research;design;Devices;Diet;Diet Records;dietary;Dietary Assessment;Dietary intake;Dietitian;Dimensions;Disease;Disease Outcome;Domiciles;doubly-labeled water;Eating;Eating Behavior;Effectiveness;effectiveness evaluation;electronic data;Energy Intake;Engineering;Ensure;Epidemiologist;epidemiology study;evidence base;experience;feeding;Food;Funding;Goals;Health;Hour;Human;Image;Image Analysis;improved;Individual;Ingestion;Intake;intervention program;Interview;Location;Machine Learning;Malignant Neoplasms;Measurement;Measures;medical specialties;men;Methods;Modernization;Monitor;multidisciplinary;novel;nutrition;Obesity;Outcome Study;Paper;Participant;Pattern;Performance;personalized nutrition;Persons;Policies;Population;Population Group;Population Heterogeneity;Precision Health;precision nutrition;preference;Procedures;Process;Randomized, Controlled Trials;Reporting;Research;Research Design;Research Personnel;Resources;response;Sample Size;Sampling;scale up;Science;Scientist;Secure;Self Administration;sensor;Site;social;System;Technology;Telephone;Testing;Time;tool;Translational Research;United States National Institutes of Health;Validation;Variant;web-based tool;Woman;Work

PROJECT_TITLE: Traditional and New Dietary Assessment Methods (TANDAM) for Personalized Nutrition


ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: LANCASTER

ORG_NAME: SIMULATIONS PLUS, INC.

PHR: Ocular PBPK/PD Model Extrapolation from Animal to Human – Project Narrative The goal of this project is to develop and validate a physiologically-based pharmacokinetic (PBPK) / pharmacodynamic (PD) modeling strategy for ophthalmic drug products to support translation from preclinical species to human. This will be achieved through an exhaustive review expanding the knowledge base of preclinical and clinical Pharmacokinetic (PK)/PD data sets and legacy models for ophthalmic products, as well as developing mechanistic PBPK/PD models in preclinical species in the Ocular Compartmental Absorption and Transit™ (OCAT™) model within the GastroPlus® software program and extrapolating to human PBPK/PD models. The findings from this project will help identify knowledge gaps and new strategies to support interspecies translation for ocular drug delivery and establish scientific and regulatory standards for supporting innovative development and performing bioequivalence assessments.

PI_NAMEs: SPIRES, JESSICA ROSE (contact)

PROGRAM_OFFICER_NAME: TAN, MINGLIANG

PROJECT_TITLE: Development and Validation of a PBPK/PD Modeling Strategy for Ophthalmic Drug Products to Support Translation from Preclinical Species to Human


NIH_SPENDING_CATS: Breast Cancer;Cancer;Estrogen;Genetics;Precision Medicine;Women's Health Research

ORG_CITY: BUFFALO

ORG_NAME: ROSWELL PARK CANCER INSTITUTE CORP

PHR: RELEVANCE: Breast cancer is the 2nd leading cause of the women’s cancer related death in the United States. Understanding improved means for the treatment of the disease is of clear public health relevance. The overall goal of this project is to advance the understanding of disease recurrence and means to more effectively intercede.

PI_NAMEs: KNUDSEN, ERIK  (contact);WITKIEWICZ, AGNIESZKA

PROGRAM_OFFICER_NAME: AGYIN, JOSEPH KOFI

PROJECT_TERMS: 13q;Adjuvant Chemotherapy;Affect;antagonist;Aromatase Inhibitors;Biological;Breast Cancer Model;Breast Cancer Patient;Bypass;CDK2 gene;CDK4 gene;Cell Cycle;Cell Cycle Arrest;Cell Cycle Deregulation;Cell Cycle Progression;Cell Cycle Regulation;Cell model;Cessation of life;Clinic;Clinical;Complex;Critical Pathways;Cytostatics;Data;de novo mutation;Disease;Disease Progression;drug use screening;Estrogen Antagonists;Estrogen receptor positive;Estrogen Receptor Status;Estrogen Receptors;Estrogen Therapy;Estrogens;Event;Evolution;Fulvestrant;Gene Dosage;Gene Expression Profile;Gene Targeting;Genetic;genetic evolution;genetic selection;Goals;Hormonal;hormone therapy;improved;in vivo;inhibitor;Intervention;Malignant Breast Neoplasm;Malignant Neoplasms;Metastatic breast cancer;Modeling;Molecular Target;Neoplasm Metastasis;next generation;Organoids;Pathway interactions;patient derived xenograft model;Patients;personalized approach;Pharmacologic Substance;Pre-Clinical Model;pressure;Process;prognostic;programs;Proliferating;public health relevance;Publishing;receptor function;Recurrent disease;Regimen;Regulatory Pathway;Relapse;Resistance;response;Retinoblastoma Genes;Risk;Sampling;Seminal;Signal Pathway;targeted agent;targeted treatment;Therapeutic;Therapeutic Intervention;therapeutic target;therapy resistant;treatment response;tumor;tumor heterogeneity;Tumor Suppressor Proteins;United States;Woman;Work

PROJECT_TITLE: RB tumor suppressor as a therapeutic target in ER-positive breast cancer

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 1 Study Section[MCT1]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Lung;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE Bone sarcomas are a heterogeneous group of rare tumors that are poorly characterized at the molecular and drug resistance level and for which clinical outcomes have not significantly improved over the past decade. We have developed a pipeline to establish bone sarcoma organoids from clinical samples and screen hundreds of drugs, paired with whole-genome sequencing to identify mutational correlates of drug sensitivity. Here, we will apply this validated pipeline to study how the molecular and pharmacologic behavior of bone sarcomas differs spatially within a single patient (Aim 1) and how they vary during the transition from curable primary to lethal metastatic disease (Aim 2).

PI_NAMEs: BOUTROS, PAUL CHRISTOPHER;SORAGNI, ALICE  (contact)

PROJECT_TERMS: Adjuvant Chemotherapy;Affect;aggressive therapy;Architecture;Behavior;Biological Models;Biopsy;Bone neoplasms;Bone Tissue;cancer diagnosis;Cell Line;Cessation of life;chemotherapy;Child;Clinical;Clinical Trials;Connective Tissue;Cytotoxic Chemotherapy;Data;Diagnosis;Disease;driver mutation;Drug resistance;Drug Screening;drug sensitivity;Evolution;exome;genome sequencing;Genomics;Germ Lines;Histologic;improved;Link;Lung;Lung nodule;Malignant Neoplasms;Metastatic Neoplasm to the Lung;model development;Modeling;Molecular;Mutation;Neoadjuvant Therapy;Neoplasm Metastasis;Newly Diagnosed;Operative Surgical Procedures;Organoids;Osteosarcoma;Outcome;Patients;Pediatric Neoplasm;Persons;Pharmaceutical Preparations;pharmacologic;Population;Portraits;pressure;Primary Neoplasm;rare cancer;reconstruction;Relapse;Resistance;response;Sampling;Sarcoma;screening;soft tissue;Specimen;Structure;Survival Rate;System;targeted treatment;Techniques;Technology;Testing;Therapeutic;therapeutic development;therapy resistant;Time;Tissue Sample;Treatment Failure;treatment response;tumor;Tumor Subtype;whole genome

PROJECT_TITLE: The Evolution of Sarcoma Drug Sensitivity through Time and Space

STUDY_SECTION: DT

STUDY_SECTION_NAME: Developmental Therapeutics Study Section[DT]


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Lung;Lung Cancer;Networking and Information Technology R&D (NITRD);Nutrition;Obesity;Physical Activity;Prevention;Rare Diseases;Telehealth

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Physical activity can reduce risk for a variety of chronic diseases including several types of cancer but, unfortunately, many individuals try but fail to be active (e.g., think New Year’s Resolutions). The purpose of this project is to evaluate if an intervention that uses methods from control systems engineering to adjust support to each person’s changing needs will promote increased physical activity compared to another intervention that does not use these methods.

PI_NAMEs: HEKLER, ERIC  (contact);RIVERA, DANIEL E

PROGRAM_OFFICER_NAME: VANDERPOOL, ROBIN CLINE

PROJECT_TERMS: actigraphy;adaptive intervention;Adherence;Adult;aged;Behavior;behavior change;Body Composition;Body Weight decreased;cancer prevention;Cancer Prevention Intervention;cancer risk;cancer type;Chronic Disease;Colon Carcinoma;Complex;cost effectiveness;Data;digital health;digital platform;Ecological momentary assessment;Education;Endometrial Carcinoma;Engineering;Event;exercise intervention;Fatty acid glycerol esters;Feedback;fitbit;global health;Glycosylated hemoglobin A;Goals;Guidelines;Health;high risk;high risk population;Hip region structure;Human;improved;Individual;innovation;Intervention;Literature;Maintenance;Malignant Breast Neoplasm;Malignant neoplasm of esophagus;Malignant neoplasm of lung;Malignant neoplasm of urinary bladder;Malignant Neoplasms;malignant stomach neoplasm;Mathematics;Measurement;Measures;Mental Health;Methods;mhealth interventions;Modeling;Monitor;multiphase optimization strategy;Nature;Obesity;Outcome;Overweight;Pain;Participant;Patient Outcomes Assessments;Persons;Physical activity;pilot test;Positive Reinforcements;prevent;Public Health;randomized trial;Randomized, Controlled Trials;Recommendation;Renal Carcinoma;Research;Resolution;response;Risk;Risk Reduction;Sequential Multiple Assignment Randomized Trial;simulation;Smoking;social cognitive theory;Stress;Substance abuse problem;System;Techniques;Testing;Time;tool;treatment arm;vigorous intensity;Walking;wearable device;Weight maintenance regimen;Work

PROJECT_TITLE: Optimizing Individualized and Adaptive mHealth Interventions via Control Systems Engineering Methods

STUDY_SECTION: PRDP

STUDY_SECTION_NAME: Psychosocial Risk and Disease Prevention Study Section[PRDP]


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Neurosciences;Radiation Oncology;Rare Diseases

PHR: PROJECT NARRATIVE In this proposal we aim to investigate two key metabolic players that mediate metabolic plasticity in cancer cells during and after radiation that ultimately result in therapy resistance. The oxidative stress induced by radiation activates NRF2, the master regulator of cellular antioxidant response, but it inactivates the glycolytic enzyme PKM2, with the ultimate result of rewiring of cellular metabolism in a way that supports an antioxidant response. Interfering with the PKM2 function and the NRF2 pathway has the potential to sensitize GBM to RT.

PI_NAMEs: VLASHI, ERINA  (contact)

PROGRAM_OFFICER_NAME: PRASANNA, PAT G

PROJECT_TERMS: Address;Affect;Antioxidants;Automobile Driving;Back;blood-brain barrier crossing;brain tissue;cancer cell;cancer type;Carbon;Cell Nucleus;Cell Survival;Cells;Cellular Metabolic Process;Characteristics;Clinic;combat;Consumption;Cytoplasm;Data;Defense Mechanisms;Dependence;Disabling;Disease;Disease Outcome;Dose;Dose Fractionation;effective therapy;Enzymes;Erythroid;flexibility;frontier;Genes;Glioblastoma;Glioma;Glucose;glucose metabolism;Glutamine;Glutathione Disulfide;Glycolysis;Goals;Homeostasis;Human;human model;improved;improved outcome;In Vitro;in vivo;inorganic phosphate;Investigation;Ionizing radiation;Knowledge;Mediating;Metabolic;metabolic phenotype;Metabolism;Modality;Molecular Conformation;mouse model;NADP;Normal Cell;novel;Nuclear;overexpression;Oxidation-Reduction;Oxidative Stress;Oxidative Stress Induction;Pathway interactions;Patients;Pentosephosphate Pathway;Phosphotransferases;prevent;Production;programs;Proliferating;Protein Isoforms;Pyruvate Kinase;Radiation;radiation effect;Radiation Oncology;radiation resistance;radiation response;Radiation therapy;Recurrence;Recycling;Regimen;Resistance;response;Role;Route;Shunt Device;small molecule;Specimen;stem cells;Supporting Cell;System;Testing;Therapeutic;therapy outcome;therapy resistant;Time;transcription factor;Transcription Initiation;Translations;Treatment Failure;tumor;tumor metabolism;tumor microenvironment;uptake

PROJECT_TITLE: Drivers of metabolic plasticity promote radiation resistance in glioblastoma multiforme

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Childhood Leukemia;Clinical Research;Genetics;Hematology;Human Genome;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: MILWAUKEE

ORG_NAME: VERSITI WISCONSIN, INC.

ORG_STATE: WI

PHR: PROJECT NARRATIVE Acute myeloid leukemia is an aggressive blood cancer that is typically incurable and fatal with current treatments. We have discovered that the survival of AML cells, unlike healthy white blood cells, depends on an enzyme called Sirtuin 5, for which there are no drug or targeted treatment options. We will thoroughly characterize the biology of Sirtuin 5 and simultaneously work to develop a drug to treat patients with acute myeloid leukemia.

PI_NAMEs: DEININGER, MICHAEL W. (contact)

PROGRAM_OFFICER_NAME: KLAUZINSKA, MALGORZATA

PROJECT_TERMS: Acute Myelocytic Leukemia;acute myeloid leukemia cell;Allogenic;Apoptosis;Attenuated;BCL2 gene;Biochemical;Biological Availability;Biology;biomarker identification;Bone Marrow;branched-chain-amino-acid transaminase;cancer cell;Catabolism;CD34 gene;Cell Death;Cell Line;Cell Survival;Cells;chemotherapy;Clinical;clinical development;CRISPR/Cas technology;Data;Dependence;Development;Drug Targeting;Energy Metabolism;Enzymes;Equilibrium;Exhibits;exome sequencing;experience;Fatty Acids;flexibility;FLT3 gene;FLT3 inhibitor;Future;Gene Expression Profile;Genes;Genetic;Genotype;Glutamine;Glycolysis;Growth;Hematologic Neoplasms;Hematopoietic;Hematopoietic Neoplasms;Hematopoietic Stem Cell subsets;Hematopoietic stem cells;Homeostasis;Impairment;In complete remission;In Vitro;in vivo;inhibitor;Isocitrate Dehydrogenase;knock-down;Knock-out;Lead;leukemia initiating cell;leukemia treatment;Leukemic Cell;Leukemic Hematopoietic Stem Cell;leukemic stem cell;leukemogenesis;Leukocytes;Lysine;Malignant - descriptor;Metabolic;Metabolic Pathway;Metabolic stress;Metabolism;meter;Minor;Mitochondria;mitochondrial metabolism;MLL-AF9;mouse model;Mus;mutant;Myelogenous;Myeloid Leukemia;Myeloproliferative disease;nanomolar;new therapeutic target;novel;novel therapeutics;Oncogenes;Organ;oxidation;Oxidation-Reduction;Oxidative Phosphorylation;Patients;Permeability;Pharmaceutical Preparations;Pharmacotherapy;Phenotype;Prognosis;Proliferating;Reagent;Reduced Glutathione;Regulation;Relapse;relapse patients;Resistance development;resistance mutation;response;Role;Sampling;scaffold;segregation;Sirtuins;small hairpin RNA;Solid Neoplasm;Somatic Mutation;stable isotope;Stem cell transplant;stem cells;Stress;Superoxides;targeted treatment;Testing;Therapeutic;tool;transcriptome sequencing;tumor heterogeneity;Validation;Work

PROJECT_TITLE: Targeting the Metabolic Regulator SIRT5 in Acute Myeloid Leukemia

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OBT-Q(02)M]


NIH_SPENDING_CATS: Aging;Cancer;Cancer Genomics;Clinical Research;Genetic Testing;Genetics;Human Genome;Precision Medicine;Prevention;Prostate Cancer;Urologic Diseases

ORG_CITY: NEW YORK

ORG_DEPT: GENETICS

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Project Narrative While prostate cancer screening reduces death from prostate cancer, it does so at the cost of unnecessary treatment of men with nonaggressive disease. To address this, we propose to identify inherited genetic changes that influence survival time after a diagnosis of prostate cancer and incorporating such genetic information into prostate cancer screening tools. If successful, this will enable more precise prostate cancer screening, reducing both death from prostate cancer and unnecessary treatment.

PI_NAMEs: KLEIN, ROBERT J. (contact)

PROGRAM_OFFICER_NAME: MCKEE, TAWNYA C

PROJECT_TERMS: Address;Adverse event;Biochemical;Biological Markers;Biology;biomarker panel;Biopsy;cancer diagnosis;Cancer Etiology;Cancer Patient;cancer survival;Cells;Cessation of life;Clinic;Clinical;clinical risk;clinical translation;clinically significant;Code;cohort;cost;Data;Diagnosis;Disease;Disease Progression;Distant Metastasis;Early Diagnosis;exome sequencing;follow-up;Genes;Genetic;Genetic Determinism;genetic information;genetic predictors;genetic risk factor;Genetic study;genetic testing;genetic variant;genome wide association study;Genomic approach;Genomics;Germ Lines;Hematopoietic Neoplasms;Heritability;high risk;high risk men;Hospitals;Image;Impairment;improved;Indolent;Inherited;insight;kallikrein 4;Kininogenase;Knowledge;Length;Malignant - descriptor;Malignant neoplasm of prostate;Malignant Neoplasms;men;middle age;model design;Modeling;Mutation;novel;Pathway interactions;peripheral blood;PF4 Gene;Play;population based;predictive marker;Price;Prognostic Factor;Prostate;prostate cancer progression;Prostate Cancer therapy;PSA screening;Quality of life;rare variant;Recurrence;Reflex action;Risk;risk stratification;Role;screening;Screening for Prostate Cancer;Screening procedure;Signal Transduction;Single Nucleotide Polymorphism;Testing;Time;trait;Transcription Alteration;transcriptome;Translating;Twin Studies;United States;unnecessary treatment;Variant;Work

PROJECT_TITLE: Genetic Predictors of Prostate Cancer Survival

STUDY_SECTION: CBSS

STUDY_SECTION_NAME: Cancer Biomarkers Study Section[CBSS]


ORG_CITY: OMAHA

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: Project Narrative We and others have demonstrated a causal role for an upregulated Claudin-1 expression in promoting colorectal cancer (CRC) metastasis. Here we propose to develop a novel inhibitor for preclinical testing and determine the specificity, efficacy and molecular mechanism for inhibiting CRC.

PI_NAMEs: DHAWAN, PUNITA  (contact);HOPKINS, COREY R.

PROGRAM_OFFICER_NAME: CHEN, WEIWEI

PROJECT_TERMS: analog;Anoikis;anticancer activity;Applications Grants;Binding;Biochemical;Biology;Biometry;cancer cell;cancer therapy;Cell Line;Cells;Cessation of life;Chemicals;Chemoresistance;claudin-1 protein;Clinical Management;Clinical Research;cohort;colon cancer metastasis;colon cancer patients;colon cancer progression;Colon Carcinoma;Colorectal Cancer;colorectal cancer metastasis;colorectal cancer progression;colorectal cancer treatment;Colorectal Surgery;Complex;Crystallography;Data;design;Diabetic Nephropathy;Diagnosis;Diagnostic Neoplasm Staging;Disease Management;Disparate;Disseminated Malignant Neoplasm;Distant;Drug Kinetics;efficacy evaluation;Ephrins;Epitopes;Fluorouracil;Genetic;Genetically Engineered Mouse;Goals;gut homeostasis;Hepatitis C;improved;in silico;In Vitro;in vitro Model;in vivo evaluation;inhibitor;Invaded;Investigation;Knowledge;Laboratories;Libraries;Liver;Lung;Malignant Neoplasms;Mediating;metastatic colorectal;Microsomes;Modeling;Molecular;mortality;mouse model;Mus;mutant;Neoplasm Metastasis;Nonmetastatic;novel;novel therapeutics;Oncogenic;Organ;Organoids;Outcome;overexpression;Pathology;patient derived xenograft model;Patients;Pharmaceutical Chemistry;Pharmacologic Substance;Phenotype;Play;preclinical study;Preclinical Testing;Property;Protein Isoforms;Proteins;Proto-Oncogenes;Qualifying;receptor;Reporting;Resistance;Risk;Role;Sampling;Scientist;side effect;Signal Pathway;Signal Transduction;Site;small molecule inhibitor;Specificity;src-Family Kinases;targeted treatment;Testing;Therapeutic;therapy development;therapy resistant;Time;tool;Toxic effect;translational potential;tumor;tumor growth;tumor xenograft;v-src Oncogenes

PROJECT_TITLE: Impact of CLDN1 inhibition on chemoresistance and metastasis of colon cancer

STUDY_SECTION: DMP

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology Study Section[DMP]


ORG_CITY: BOSTON

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF MASSACHUSETTS BOSTON

PHR: PROJECT NARRATIVE The University of Massachusetts, Boston (UMass Boston) and Dana-Farber/Harvard Cancer Center (DF/HCC) Partnership is committed to further developing a shared rigorous and collaborative transdisciplinary cancer and disparities-related research program that is primed for “Bridging the Divides: Innovations to Address Gaps in Cancer Disparities Research, Education, Outreach and Infrastructure.” Sophisticated research projects are proposed across several areas of basic biomedical and population sciences that will employ evidence and methods to converge upon and impact cancer and cancer health disparities at multiple levels of analysis. These projects, together with state-of-the-art Outreach and Research Education Cores and creative Research Design and Analysis Core and Genomics Cores, will serve to build research capacity and infrastructure at UMass Boston, expand the cancer disparities platform and community outreach programs at DF/HCC; and make, at an elevated level, significant advances to the science of cancer control.

PI_NAMEs: COLON-CARMONA, ADAN  (contact);MACOSKA, JILL A.;VISWANATH, KASISOMAYAJULA

PROGRAM_OFFICER_NAME: WALI, ANIL

PROJECT_TERMS: Absenteeism;Address;Advanced Malignant Neoplasm;anti-cancer research;Area;Biology;Boston;Cancer Center;Cancer Control;cancer health disparity;Cancer health equity;Cancer Science;career;career development;Charge;Color;Communities;community engagement;Community Networks;community organizations;Community Outreach;Creativeness;Data;Data Set;Dedications;Discipline;Disparity;dissemination science;Education;education research;Ethnic Origin;experience;Experimental Designs;experimental study;Faculty;Foundations;Funding;Genomics;Goals;Government;Grant;Health Disparities Research;implementation science;Incidence;Infrastructure;innovation;Institution;Joints;Lasers;Leadership;Malignant Neoplasms;Massachusetts;member;Mentors;Methods;Modeling;Morbidity - disease rate;mortality;outreach;outreach program;Phase;Population;Population Group;Population Heterogeneity;Population Sciences;Postdoctoral Fellow;programs;Race;Research;research and development;Research Design;Research Infrastructure;Research Personnel;Research Project Grants;research study;Resource Sharing;Resources;Science;socioeconomic disparity;Solid;Source;Students;Training;translational model;translational potential;Underrepresented Populations;Underserved Population;United States National Institutes of Health;Universities

PROJECT_TITLE: 1/2 The University of Massachusetts, Boston - Dana-Farber/Harvard Cancer Center U54 Comprehensive Partnership for Cancer Disparities Research


ORG_CITY: TALLAHASSEE

ORG_NAME: FLORIDA AGRICULTURAL AND MECHANICAL UNIV

ORG_STATE: FL

PHR: PROJECT NARRATIVE – OVERALL COMPONENT The long term goals of the CaRE2 center are to reduce cancer disparities in Black/African American and Hispanic/Latinx individuals, to train and increase the pool of 120 underrepresented Black/African American and Hispanic/Latinx scientists conducting health disparity research, to increase research capacity at an HBCU (FAMU), and to increase cancer disparity research at UF and USC-NCCC. The proposed two full projects and pilot project include investigators from the three institutions and will leverage on specimens collected across the partnership from Black/African American and Hispanic/Latinx, representing a wide range of subpopulations within these minority groups. Thus, our studies will reveal unprecedented findings about these two understudied minority populations, will be instrumental in transferring cutting edge and innovative technologies to FAMU, and will expand in a significant way the research focus at UF and USC-NCCC to address cancer health disparities in pancreas and lung cancers.

PI_NAMEs: ABLORDEPPEY, SETH Y;HUGHES-HALBERT, CHANITA A.;REAMS, ROMONIA RENEE (contact);STERN, MARIANA C;WILKIE, DIANA J

PROGRAM_OFFICER_NAME: BARFIELD-STEWARD, WHITNEY

PROJECT_TERMS: Address;Advocate;African;African American;American;anti-cancer research;Award;Back;Benchmarking;Bioinformatics;Biological;Biological Models;Biomedical Research;Black American;Black Populations;Black race;California;Cancer Center;Cancer Control;cancer health disparity;Cancer Model;Cancer Patient;cancer prevention;career development;Caribbean region;Caring;Catchment Area;Censuses;Central American;Communities;Community Outreach;community partnership;Complex;Comprehensive Cancer Center;Cultural Diversity;Development;Disparity;disparity reduction;Doctor of Philosophy;drug development;Education;education research;Educational Materials;Effectiveness;Evaluation;Extramural Activities;Florida;Fostering;Funding;genetic makeup;genome resource;Goals;Grant;Health;Health Disparities Research;health disparity populations;health equity;Heterogeneity;Hispanic;improved;improved outcome;Incidence;Individual;Infrastructure;innovation;innovative technologies;Institution;Latino;Latino Population;Latinx;Latinx population;Leadership;Location;Malignant neoplasm of lung;Malignant neoplasm of pancreas;Malignant neoplasm of prostate;Malignant Neoplasms;meetings;member;Mentors;Methodology;Methods;Mexican Americans;Minority;minority communities;Minority Groups;minority patient;minority trainee;mortality;novel anticancer drug;Outcome;outreach;patient population;Pilot Projects;podcast;Population;Population Heterogeneity;Postbaccalaureate;Postdoctoral Fellow;Process;programs;Publications;Publishing;Reporting;repository;Research;Research Infrastructure;Research Personnel;Research Project Grants;Research Training;Resource Sharing;Resources;Scientist;Series;social determinants;South American;Specimen;Students;success;Tissue Model;tool;Training;Training and Education;translational cancer research;Translational Research;Underrepresented Minority;Underrepresented Students;Underserved Population;understudied cancer;United States;Universities;University of Southern California Norris Cancer Center;US State;Use Effectiveness;Work

PROJECT_TITLE: 1/3 Florida-California Cancer Research, Education and Engagement (CaRE2) Health Equity Center


ORG_CITY: HOUSTON

ORG_NAME: METHODIST HOSPITAL RESEARCH INSTITUTE

ORG_STATE: TX

PHR: PROJECT NARRATIVE Metastatic bladder cancer is a devastating disease with a 5-year survival rate of only 5.4%. While the initial steps of the metastatic cascade are rather well defined, identification of targets to block this process continues to be a major clinical challenge. Discovering the regulatory mechanisms by which the metastatic microenvironment support tumor cell colonization and survival will enable design of new strategies not only targeting the primary tumors, but also eradicating metastatic foci – a potential new breakthrough.

PI_NAMEs: CHAN, KEITH SYSON  (contact)

PROGRAM_OFFICER_NAME: SNYDERWINE, ELIZABETH G

PROJECT_TERMS: Address;Binding;Bioinformatics;Biological Process;Bladder Carcinoma;Bladder Neoplasm;bladder transitional cell carcinoma;C-terminal;cancer cell;cancer type;Categories;Cell Nucleus;Cell secretion;Cells;Cessation of life;ChIP-seq;Clinical;clinical translation;Clustered Regularly Interspaced Short Palindromic Repeats;Collagen;Collagen Receptors;Communication;Conceptions;Data;design;Disease;Disease Management;Distal;DNA Binding;Ectopic Expression;Extracellular Matrix;Family;Fibroblasts;Funding;gamma secretase;Genes;Goals;Image;in vivo;innovation;Invaded;Investigation;Kininogenase;Knock-out;Knowledge;lead candidate;Ligands;Luciferases;Lung;Malignant Epithelial Cell;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Mediating;Metastatic Neoplasm to the Lung;metastatic process;migration;Modality;Mutate;N-terminal;Nature;Neoplasm Metastasis;neoplastic cell;notch protein;novel;novel strategies;Nuclear;Nuclear Translocation;overexpression;Pattern;Peptide Hydrolases;pharmacologic;Phenotype;Phosphorylation;Phosphorylation Site;Pilot Projects;Play;precision medicine;Primary Neoplasm;Process;Progression-Free Survivals;Property;Protein Fragment;Proteins;receptor;Receptor Activation;Receptor Signaling;Regulation;respiratory smooth muscle;Role;scaffold;Signal Transduction;Site;Smooth Muscle Myocytes;Specific qualifier value;src Homology Region 2 Domain;success;Survival Rate;Testing;Therapeutic Intervention;therapeutic target;tumor;tumor microenvironment;Tumor Volume;Tyrosine Phosphorylation;Tyrosine Phosphorylation Site

PROJECT_TITLE: Distinct Tumor and Metastatic Collagen Microenvironments: Divergent Targeting Approaches

STUDY_SECTION: TME

STUDY_SECTION_NAME: Tumor Microenvironment Study Section[TME]


NIH_SPENDING_CATS: Cancer;Clinical Research;Data Science;Networking and Information Technology R&D (NITRD)

ORG_STATE: NY

PHR: Project Narrative While advances in cancer therapeutics have resulted in remarkable clinical responses in some patients, acquired resistance remains one of the biggest challenges towards expanding the clinical benefits to more patients. Tackling acquired therapy resistance will require collaborative efforts to elucidate resistance mechanisms, characterize the tumor microenvironment, discover new targets, identify predictive biomarkers, evaluate combination therapies, and develop real-time monitoring approaches. The goal of our proposed Coordinating and Data Management Center (CDMC) application is to coordinate the activities across the Acquired Resistance to Therapy Network (ARTNet), and to manage, integrate and disseminate the data and resources generated through the network. Leveraging cutting-edge multi-disciplinary team approaches, we will support the ARTNet to inform new strategies that can be better translated to overcome significant challenges in acquired resistance to cancer therapies.

PI_NAMEs: GOODRICH, DAVID W.;HUTSON, ALAN DAVID (contact);LIU, SONG

PROGRAM_OFFICER_NAME: VENKATACHALAM, SUNDARESAN

PROJECT_TERMS: Acceleration;Address;Adopted;biobank;Bioconductor;Bioinformatics;biomedical informatics;Biometry;Cancer Center Support Grant;cancer therapy;Clinical;cloud based;Collaborations;Combined Modality Therapy;Communities;community engagement;Comprehension;Computer software;cost;Data;data acquisition;Data Coordinating Center;data ecosystem;data harmonization;data integration;data management;data repository;Data Science;Data Set;data sharing;data sharing networks;data standards;Databases;Development;Drug Kinetics;Drug resistance;drug sensitivity;Ecosystem;Ensure;experience;Fostering;Funding;genomic data;Goals;Hand;Immunooncology;Immunotherapy;improved;Informatics;Information Technology;Infrastructure;interoperability;Malignant Neoplasms;Methods;multidisciplinary;Multiomic Data;National Human Genome Research Institute;open source;operation;outreach;Patients;Pharmacodynamics;pharmacokinetics and pharmacodynamics;Police;Policies;pre-clinical;predictive marker;Principal Investigator;Productivity;PubMed;quality assurance;real time monitoring;Records;Reproducibility;Research;Research Personnel;Research Project Grants;Resistance;resistance mechanism;Resource Sharing;Resources;response;Services;shared repository;support network;Text;Therapeutic;therapy resistant;tool;Translating;translational oncology;tumor microenvironment;United States National Institutes of Health;virtual;Visualization

PROJECT_TITLE: Coordinating and Data Management Center for Acquired Resistance to Therapy Network


ED_INST_TYPE: HOSPITALS

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: Overall NARRATIVE The Houston Center for Acquired Resistance Research (H-CARR) will act as the organizing entity for a multi- institutional, multi-disciplinary effort to detect acquired cisplatin resistance early in development and generate molecular and metabolic strategies for overcoming it. Investigators from Baylor College of Medicine and the University of Texas MD Anderson Cancer Center will investigate interactions between cancer cells, infiltrating immunocytes and neurons to both understand the critical drivers of cisplatin resistance in head and neck squamous cell carcinoma and develop precision oncology approaches to its clinical utilization in this deadly cancer and other similar solid tumors.

PI_NAMEs: MYERS, JEFFREY NICHOLAS (contact);SANDULACHE, VLAD C

PROGRAM_OFFICER_NAME: KAI, MIHOKO

PROJECT_TERMS: Acute;Adrenergic Agents;afferent nerve;Algorithms;Amino Acids;Biological;Biological Markers;Biomass;cancer cell;Cancer Etiology;cancer imaging;cancer survival;Carbon;Cessation of life;Cetuximab;chemotherapeutic agent;chemotherapy;Chronic;Cisplatin;Citric Acid Cycle;Clinical;clinical application;clinical practice;Clinical Trials;college;Data;Dependence;design;Development;Distant Metastasis;early detection biomarkers;experimental study;Extinction;FADH2;Generations;Genomics;Genotoxic Stress;Glutathione;Glycolysis;Goals;GPX2 gene;Head and Neck Squamous Cell Carcinoma;Human;Human Papillomavirus;Image;imaging study;Immune checkpoint inhibitor;immunogenic;improved;Individual;individual patient;Infiltration;Infrastructure;insight;Institution;Invaded;Link;Magnetic Resonance Imaging;Malignant neoplasm of esophagus;Malignant neoplasm of lung;Malignant Neoplasms;Medicine;Metabolic;metabolic imaging;Metabolic stress;metabolomics;Modality;Modeling;Molecular;multidisciplinary;Mutation;Neoadjuvant Therapy;Neoplasm Circulating Cells;Neoplasm Metastasis;neoplastic cell;Neurons;non-invasive imaging;novel;Paracrine Communication;Pathway interactions;Patients;Pharmaceutical Preparations;Phenotype;Pre-Clinical Model;precision oncology;prevent;Production;prospective;Pyruvate;Regimen;Research;Research Personnel;Resistance;Resistance development;response;Role;Signal Transduction;Solid Neoplasm;standard of care;Stress;targeted agent;Technical Expertise;Testing;Time;TP53 gene;transcriptomics;translational potential;tumor;Tumor Biology;Tumor Immunity;tumor metabolism;tumor-immune system interactions;University of Texas M D Anderson Cancer Center;Upper aerodigestive tract cancer


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Pancreatic Cancer;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_NAME: RESEARCH INST OF FOX CHASE CAN CTR

ORG_STATE: PA

PHR: PROJECT NARRATIVE Pancreatic Cancer is far from being the most common cancer in the USA, yet it is projected to become the second deadliest (following lung cancer) by the year 2026 and no effective therapies are available to treat this cancer. This study will identify possible routes to restore the naturally protective activity of stromal cells that neighbor pancreatic tumors, which could prevent or delay the development and progression of Pancreatic Cancer. Further, results from the study will indicate whether the proposed “stroma normalization” could be informed by systemically in patients (i.e., in blood).

PI_NAMEs: CUKIERMAN, EDNA  (contact)

PROGRAM_OFFICER_NAME: WOODHOUSE, ELIZABETH

PROJECT_TERMS: 3-Dimensional;Actin-Binding Protein;Actins;Animal Model;anti-cancer;antitumor effect;Archives;Biochemical;Biogenesis;Biological Markers;Blood;Bundling;cancer type;carcinogenesis;Cartoons;Cell secretion;Cells;Clinical;Clinical Trials;Data;Data Set;design;Desmoplastic;Detection;Development;ECM receptor;effective therapy;Endocytosis;Equilibrium;Exhibits;extracellular;Extracellular Matrix;extracellular vesicles;Feedback;Fibroblasts;Future;gain of function;genetic regulatory protein;Goals;Growth;Harvest;Homeostasis;Human;Immune system;immunoregulation;improved;In Vitro;in vivo;Inflammatory;inhibitor;Integrin alpha5beta1;Integrins;interstitial;Knock-out;Link;loss of function;Malignant neoplasm of lung;Malignant neoplasm of pancreas;Malignant Neoplasms;Measures;Metabolic;Metabolism;Methods;mimetics;minimally invasive;Modeling;Molecular;Molecular Conformation;Monitor;mouse model;Multivesicular Body;Mus;netrin-G1;novel;Nutritional;Outcome;pancreatic cancer cells;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;pancreatic ductal adenocarcinoma model;pancreatic neoplasm;Pathologic;Patients;Peptide Receptor;Plasma;Polarization Microscopy;Population;postsynaptic;presynaptic;prevent;Process;Production;Proteins;proteomic signature;PTK2 gene;receptor;receptor binding;receptor function;Regulation;Reporting;response;restraint;Role;Route;sample archive;Sampling;Series;Signal Transduction;Stress;Stromal Cells;Structure;Supporting Cell;System;Testing;three dimensional cell culture;Tissues;transcriptome sequencing;Transforming Growth Factor beta;tumor;Tumor Immunity;Tumor Promotion;Work

PROJECT_TITLE: Pancreatic cancer-associated fibroblasts: function, detection, and regulation


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Infectious Diseases;Neurodegenerative;Neurosciences

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: PROJECT NARRATIVE/PUBLIC HEALTH RELEVANCE: The to project neurocognitive diversity supplement would provide i mportant mentoring, training, research and educational opportunities  Dr. Nicholas Hampilos, a Postdoctoral Fellow in Radiology. The proposed diversity supplemental research aims to use cellular and neuroimaging techniques to better understand what may be contributing to impairments present in the elderly living with HIV.

PI_NAMEs: NDHLOVU, LISHOMWA C (contact);VALCOUR, VICTOR

PROGRAM_OFFICER_NAME: MARIC, MAJA

PROJECT_TERMS: Alzheimer's Disease;antiretroviral therapy;Award;Basal Ganglia;career;Career Transition Award;Cells;Cellular Immunology;Clinical Research;Cognitive;Data;Disease;Education;Elderly;epigenome;epigenomics;experience;Foundations;Funding;Future;geriatric neuroHIV;HIV;HIV-associated cognitive impairment;Image;Immunophenotyping;Impairment;Individual;Laboratory Research;Linear Regressions;Magnetic Resonance Imaging;Magnetic Resonance Spectroscopy;Measures;Mentors;mild cognitive impairment;monocyte;Myelogenous;Myeloid Cells;Neurocognitive;neuroimaging;Neuronal Injury;neuropathology;Oxidative Stress;parent project;Parents;Peripheral;Persons;Phenotype;Population;Postdoctoral Fellow;Privatization;Protons;public health relevance;Radiology Specialty;Research;Research Project Grants;Secure;skills;Surface;Techniques;Training;Writing

PROJECT_TITLE: Harnessing Single Cell Epigenome-wide profiling of Myeloid cells to Compare and Contrast Alzheimer's from HIV-Associated Cognitive Dysfunction

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(02)-M]


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

ORG_CITY: CAMBRIDGE

ORG_NAME: ACOUSTICABIO, INC.

ORG_STATE: MA

PHR: NARRATIVE Currently, millions of patients must travel to the hospital to endure painful, expensive, and time-consuming intravenous injections in order to receive their life-saving medications. The proposed project aims at overcoming barriers to existing formulations by reducing those large IV bags into highly concentrated, small volume injections that patients can self-administer from the comfort of their own home. This proprietary Acoustophoretic Printing technology addresses current microparticle production limitations enabling the generation of hydrogel-based microparticles that encapsulate and stabilize highly concentrated drugs, improving both standard of care and manufacturing practices.

PI_NAMEs: FORESTI, DANIELE  (contact)

PROGRAM_OFFICER_NAME: BROOKS, PJ

PROJECT_TERMS: Address;Alginates;Antibodies;Biological Availability;biomaterial compatibility;clinical care;Consumption;cost;dosage;Electrostatics;Encapsulated;Formulation;Generations;Good Manufacturing Process;Home;Hospital Administration;Hospitals;Hydrogels;Hydrophobicity;improved;In Vitro;in vivo;Injectable;Injections;Intravenous;intravenous injection;Life;Liquid substance;manufacture;manufacturing technology;Marketing;mechanical properties;Mechanics;Medical Care Costs;Methods;Monoclonal Antibodies;mouse model;Nature;Needles;Oils;Pain;pain reduction;particle;Particle Size;Patients;Pharmaceutical Preparations;Phase;Polymers;porous hydrogel;Printing;Production;Property;Proteins;Route;Safety;Self Administration;skills;Small Business Innovation Research Grant;small molecule;Specificity;standard of care;subcutaneous;Subcutaneous Injections;surfactant;Technology;technology platform;Therapeutic;Therapeutic Monoclonal Antibodies;therapeutic protein;Time;Travel;Variant

PROJECT_TITLE: Enabling Subcutaneous Delivery of Therapeutic Monoclonal Antibodies via Hydrogel Microparticles


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Mental Health;Prevention;Social Determinants of Health

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE While emotional well-being (EWB) promotes positive health across the lifespan, little is known about how to best increase EWB in ways that lead to downstream improvements in health. The goal of this network is to develop research resources and foster a cohesive community of interdisciplinary scholars focused on discovering which aspects of EWB are most tightly linked to physical health, which interventions most effectively increase EWB, and the biobehavioral processes that explain how EWB impacts health. The network leadership team unites three major research institutions (UCSF, Harvard, UC Berkeley), bringing together the infrastructure and scientific expertise in measurement, intervention development, and dissemination, needed to advance the science of well-being and health.

PI_NAMEs: EPEL, ELISSA S. (contact);MENDES, WENDY BERRY

PROGRAM_OFFICER_NAME: HOOKER, EMILY DIANE

PROJECT_TERMS: Affect;Aging;Area;Autonomic nervous system;Basic Science;Behavior;Big Data;biobehavior;Biosensor;burden of chronic illness;burden of illness;Cell Physiology;Chronic Disease;Cohort Studies;Collaborations;Communities;Consensus;Country;Data;data resource;Development;digital;digital health;digital platform;Early Intervention;Educational workshop;Elements;Epidemiology;Evidence based practice;experience;Family Study;FarGo;Fostering;Funding;Goals;Happiness;Harm Reduction;Health;Health and Retirement Study;Health behavior;Health Professional;Health Sciences;healthspan;healthy aging;heart rate variability;hedonic;improved;Infrastructure;innovation;insight;Institution;interdisciplinary collaboration;Intervention;Intervention Studies;Leadership;Libraries;Life;life span;Link;Loneliness;Longevity;Measurement;Measures;Mediator;Medicine;Mental Health;Mentorship;Methodology;Modeling;novel;optimism;pandemic disease;Pathway interactions;Personal Satisfaction;Persons;physical conditioning;Physiological;Physiology;Pilot Projects;Play;population health;Prevention;Process;psychosocial;Recovery;repository;Research;research and development;Research Institute;Research Personnel;Resources;restoration;Role;satisfaction;Science;Scientist;Senior Scientist;Shapes;Sleep;social;sociodemographic group;Stress;summer research;symposium;Technology;Testing;Theoretical model;therapy development;Time;tool;Training;United States National Institutes of Health;Well in self

PROJECT_TITLE: Advancing Psychosocial & Biobehavioral Approaches to Improve Emotional Well-Being


NIH_SPENDING_CATS: Neurosciences;Rare Diseases

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

PHR: LAYMAN’S STATEMENT/ NARRATIVE One known cause of smell impairment is a disruption of cilia, hair-like projections that extend from neurons in the nose into the nasal cavity. Olfactory cilia are essential for detecting odors, and genetic diseases that disrupt the cilia – called ciliopathies – have been tied to the loss of smell. The goal for this proposal is to better understand the function of olfactory cilia, how disruption to these cilia causes smell impairment, and how gene therapy approaches could be used to restore smell function in people with these disorders.

PI_NAMEs: MARTENS, JEFFREY  (contact)

PROGRAM_OFFICER_NAME: SULLIVAN, SUSAN L

PROJECT_TERMS: Actins;Affect;Amino Acid Sequence;Animal Model;Anosmia;Applications Grants;Bardet-Biedl Syndrome;base;Biochemical;Biological;Biological Assay;Biology;Cell Compartmentation;Cells;Cilia;ciliopathy;Clinical;congenital anosmia;curative treatments;Data;Defect;Detection;Disease;Electrophysiology (science);experience;F-Actin;fluorescence imaging;gene replacement;gene therapy;Genes;Genetic;Genetic Diseases;Goals;Hair;Human;Human Genetics;human model;Impairment;Individual;Infiltration;innovation;insight;Length;Lipids;Macromolecular Complexes;Maintenance;Measures;Membrane;Membrane Lipids;Molecular;Morphology;mouse model;Multiprotein Complexes;Nasal cavity;Neurons;Nose;novel;Odors;Olfactory dysfunction;Olfactory Pathways;olfactory sensory neurons;Organism;Pathogenesis;Pathogenicity;Pathologic;Patients;Penetrance;Perception;Peripheral;permissiveness;Persons;Phosphatidylinositol 4,5-Diphosphate;Phosphatidylinositols;Phosphoric Monoester Hydrolases;Physiological;Proteins;receptive field;Regulation;Reporting;response;Role;Sensory;sensory input;Signal Transduction;Signaling Protein;Site;Smell Perception;Structure;System;Techniques;Testing;Therapeutic;therapy development;virtual;Wild Type Mouse;Work

PROJECT_TITLE: Maintenance and Disassembly of Olfactory Cilia

STUDY_SECTION: CSS

STUDY_SECTION_NAME: Chemosensory Systems Study Section[CSS]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Contraception/Reproduction;Dementia;Estrogen;Menopause;Neurodegenerative;Neurosciences;Prevention;Women's Health Research

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative Women are disproportionately affected by Alzheimer’s disease (AD), yet the degree to which female reproductive aging shapes the structural and functional architecture of the human brain is severely understudied. During the menopausal transition, ovarian production of estradiol and progesterone declines by up to 90%, and these sex steroid hormones play neuroprotective roles in the brain to support the structure and function of regions vulnerable to neurodegeneration. The proposed studies will use state-of-the-art brain imaging techniques to establish the endocrine basis of neural aging in midlife women and provide critical insight into whether the brain demonstrates vulnerability to AD pathology as a function of the menopausal transition.

PI_NAMEs: PRITSCHET, LAURA  (contact)

PROGRAM_OFFICER_NAME: ROBERTS, LUCI

PROJECT_TERMS: Address;Adult;Age;age related decline;Age-associated memory impairment;Aging;aging brain;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease risk;Alzheimer’s disease biomarker;Amyloid;Amyloid deposition;anatomic imaging;Animals;Architecture;Area;Attention;Award;Biological;Biological Markers;biomarker panel;Brain;Brain imaging;brain morphology;Brain region;brain shape;Chronology;cingulate cortex;Cognitive;cognitive neuroscience;cohort;Communities;Complex;Data;dementia risk;dentate gyrus;Deposition;Disease Progression;Disproportionately impacts women;Endocrine;Estradiol;Exhibits;Female;Fogs;Framingham Heart Study;Functional Magnetic Resonance Imaging;Gonadal Steroid Hormones;Hippocampus;Hormonal;Hormone Receptor;hormone regulation;Human;human old age (65+);imaging study;Imaging Techniques;Impaired cognition;improved;Individual;insight;Investigation;Knowledge;Laboratories;Life;Liquid substance;medial temporal lobe;Memory;Menopause;Methods;middle age;Midlife women;millimeter;Molecular;Morphology;Nerve Degeneration;neural;neural circuit;Neuroendocrinology;neuroimaging;neuroimaging marker;Neurologic;neuropathology;neuroprotection;Neurosecretory Systems;Ovarian;Ovarian hormone;Participant;Pathologic;Pathology;Perimenopause;Phase;Play;Population;Positron-Emission Tomography;Postdoctoral Fellow;Postmenopause;Predisposition;Prefrontal Cortex;Premenopause;Prevalence;Production;Progesterone;Registries;reproductive;reproductive senescence;Research;Research Personnel;Research Project Grants;Resolution;response;Rest;Risk;Role;Sampling;sex;Shapes;Signal Transduction;Site;skills;Structure;symposium;Systems Analysis;tau Proteins;Training;Venipunctures;Wisconsin;Woman;Women's Health;Work

PROJECT_TITLE: Elucidating the role of endocrine aging as a risk factor for Alzheimer's Disease