NIH_SPENDING_CATS: Biotechnology;Cancer;Hematology;Immunotherapy;Networking and Information Technology R&D (NITRD);Patient Safety

PHR: PUBLIC HEALTH RELEVANCE The Administrative and Clinical Research Support Core will provide support for accounting, budgeting, fiscal reporting and communication while the clinical research support components will facilitate protocol activation and execution. Optimization of infrastructural support and improved integration of laboratory and clinical data from multiple sources will accelerate discovery, ultimately improving the health of the patients with high risk cancer.

PROJECT_TERMS: Acceleration;Accounting;Adverse effects;Agreement;Allogenic;Area;Augmented Reality;Autologous;Budgets;Calendar;cancer therapy;Case Report Form;Cell Therapy;Cells;Cellular immunotherapy;Clinical;clinical application;Clinical Data;Clinical Nursing Research;Clinical Protocols;Clinical Research;clinical translation;clinical trial implementation;Clinical Trials;Collaborations;Communication;Complex;Data Collection;data management;Development;Devices;Education;Effectiveness;Effector Cell;Enrollment;Ensure;Evaluation;Expenditure;experience;Faculty;Feedback;Financial Support;first-in-human;Fostering;Funding;Genes;Goals;Grant;Health;Hematologic Neoplasms;High-Risk Cancer;Immune;Immunotherapy;improved;Individual;Inpatients;Intervention;Joints;Knowledge;Laboratories;Leadership;Maintenance;Management Audit;meetings;member;mHealth;Minnesota;Monitor;multiple data sources;neoplastic cell;new technology;novel;novel strategies;Nurses;Nursing Research;Outpatients;Output;patient safety;Patients;Phase;Phase II Clinical Trials;prediction algorithm;Preparation;Productivity;Program Research Project Grants;programs;Progress Reports;protocol development;Protocols documentation;Provider;Public Health Informatics;public health relevance;recruit;Reporting;Research;Research Assistant;Research Personnel;Research Support;Safety;Science;Services;side effect;Strategic Planning;success;Teacher Professional Development;therapy development;timeline;tool;translational medicine;Translations;tumor;United States National Institutes of Health;Universities


ADMINISTERING_IC: DK

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: BOSTON

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_FIPS: US

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

ORG_STATE: MA

PHR: PROJECT NARRATIVE The Training Program in Molecular Metabolism enlists faculty from the of Harvard TH Chan School of Public Health and the Harvard Medical School to provide didactic and research opportunities to trainees interested in a research career in molecular metabolism. We request funding to support 3 students and 1 postdoctoral fellow per year. The program will prepare trainees to apply cutting edge multi-omic, genetic, and physiological methods to advance our understanding of areas including metabolic health and diseases such as diabetes; gastrointestinal health, such as the role of the microbiome; inflammatory and immune effects on health; obesity; and the role of factors such as aging or disease state on metabolic processes.

PI_NAMEs: BIDDINGER, SUDHA B;HOTAMISLIGIL, GOKHAN S (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Metabolism;Molecular;Training Programs

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Hepatitis;Hepatitis - B;Immunization;Infectious Diseases;Liver Disease;Pediatric;Prevention;Vaccine Related

ORG_CITY: CHAPEL HILL

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE Hepatitis B (HBV) is a leading infectious killer in sub-Saharan Africa, despite the existence of an effective vaccine. Children are especially vulnerable to HBV-related complications, but our knowledge of patterns of childhood HBV transmission in African children are incomplete. In this career development proposal, Dr. Thompson will apply comprehensive epidemiological, spatial and modeling analyses to enhance our knowledge of childhood HBV in Africa, to identify hotspots of disease, and to model spatially targeted vaccination strategies to avert future cases of HBV in African children.

PI_NAMEs: THOMPSON, PEYTON J (contact)

PROGRAM_OFFICER_NAME: FLORES, AMANDA CHRISTINE

PROJECT_TERMS: 5 year old;Address;Adult;Advisory Committees;Africa;Africa South of the Sahara;African;Age;Archives;Area;Automobile Driving;Biological;Birth;Blood;booster vaccine;career;career development;Child;Childhood;Chronic Hepatitis B;Cirrhosis;Clinical;Collaborations;Communicable Diseases;Communities;Competence;Country;Data;data repository;Democratic Republic of the Congo;Demographic and Health Surveys;design;Disease;Dose;Dryness;Epidemic;epidemic virus;epidemiologic data;Epidemiologist;Epidemiology;Equation;experience;Face;Foundations;Funding;Future;Genetic;Geographic Locations;Geography;global health;Goals;Hepatitis B;Hepatitis B Acquisition;Hepatitis B Prevalence;Hepatitis B Transmission;Hepatitis B Vaccines;Hepatitis B Virus;Hepatology;High Prevalence;Horizontal Disease Transmission;Household;Immunity;Immunization;Immunization Programs;Immunization Schedule;improved;infant infection;Infection;Intervention;intervention program;K-Series Research Career Programs;Knowledge;Laboratories;Learning;Life;Liver;Malignant neoplasm of liver;Maps;member;Mentors;Mentorship;Modeling;Morbidity - disease rate;mortality;Mothers;multidisciplinary;North Carolina;Pattern;Persons;Phylogenetic Analysis;Physicians;Population;prevent;Prevention;professor;Public Health;Public Health Schools;Qualifying;Research;research and development;Research Personnel;Resource-limited setting;Risk Factors;Route;Sampling;Scientist;serological marker;skills;Specimen;Spottings;Supervision;Surveys;Techniques;Testing;Training;Translating;transmission process;United States National Institutes of Health;Universities;Vaccination;vaccination strategy;vaccine strategy;Vaccines;vaccinology;Vertical Transmission;Virus Diseases;Vulnerable Populations

PROJECT_TITLE: Characterizing Hepatitis B Transmission in Congolese Children

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases Advisory Committee[MID]


ADMINISTERING_IC: NS

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: SALT LAKE CITY

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Narrative With experiments in this R35 grant, we hope to unravel the complexities of human neurodegenerative diseases. We will take advantage of discoveries we have made in the last decade and the lessons we have learnt from modelling human neurodegenerative diseases in cells and in animals. We will search for mechanisms that explain the death of adult nerve cells across different diseases, from those affecting coordination to those that affect muscle strength or the ability to think.

PI_NAMEs: PULST, STEFAN M. (contact)

PROGRAM_OFFICER_NAME: RANGANATHAN, SRIKANTH

PROJECT_TERMS: Address;Adult;Affect;Animal Model;Animals;Apoptotic;Ataxia;Autophagocytosis;Award;Behavioral;Cells;Cerebellar degeneration;Cessation of life;Chemicals;Complex;Cytoplasm;Deterioration;Dimensions;Disease;diversity and inclusion;dosage;Environment;experimental study;Foundations;Funding;Gene Targeting;Genes;genome-wide;Grant;Heat shock proteins;Human;human model;In Vitro;in vivo;Inherited;innovation;insight;Laboratories;Mediating;Modeling;Morphology;Motor Neuron Disease;Motor Neurons;muscle strength;mutant;Nerve Degeneration;Neurodegenerative Disorders;neuron loss;Neurons;novel;Nutrient;Pathogenicity;Phase;Physiological;polyglutamine;Principal Investigator;protein complex;protein function;Proteins;Proteomics;Purkinje Cells;Regulation;Reproducibility;Research;Resource Sharing;response;RNA metabolism;RNA Transport;RNA-Binding Proteins;Role;SCA2 protein;Scientist;Signal Transduction;small molecule;Small RNA;Spinal;Spinocerebellar Ataxias;Stress;success;Techniques;therapeutic target;Time;tool;transcriptomics;Translations

PROJECT_TITLE: Ataxin-2 complex proteins in neurodegeneration.


NIH_SPENDING_CATS: HIV/AIDS;Infectious Diseases

ORG_CITY: NEW YORK

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: PROJECT NARRATIVE HIV-1 encodes proteins that modify the host cell to create an environment that is hospitable for replication. This project aims to understand a specific interaction between an HIV-1 protein, Vif, and a human protein complex, PP2A-B56. By understanding how this interaction occurs and why this interaction is important for HIV-1 infection, we aim to identify critical weaknesses that can be targeted for drug development.

PI_NAMEs: JOHNSON, JEFFREY R (contact)

PROGRAM_OFFICER_NAME: REFSLAND, ERIC WILLIAM

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Affinity Chromatography;antiretroviral therapy;APOCEC3G gene;base editing;Binding;Biological Assay;candidate identification;cardiovascular disorder risk;CD4 Positive T Lymphocytes;cDNA Expression;Cell Line;Cells;Chronic;community transmission;CRISPR screen;CRISPR/Cas technology;Data;Development;drug development;Drug Targeting;engineered T cells;Environment;Event;Family;fitness;Flow Cytometry;Fluorescence;Gene Silencing;Genes;Genetic Screening;genome-wide;HIV-1;Holoenzymes;Human;Individual;Infection;Inflammation;Inflammatory;Label;Malignant Neoplasms;Mass Spectrum Analysis;Measures;Mediating;Metabolic Diseases;Molecular;Molecular Virology;multidisciplinary;novel;Pathway interactions;Persons;phosphoproteomics;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphorylation Site;Play;prevent;Process;protein complex;protein degradation;Protein Family;Protein phosphatase;Protein Subunits;Proteins;Proteomics;reactivation from latency;Resources;Retroviridae;Role;Signal Transduction;Site;targeted treatment;Technology;Testing;therapy development;Translations;Ubiquitination;vif Gene Products;Viral;Viral Physiology;Virion;virology;virus host interaction;Work

PROJECT_TITLE: Cellular Determinants and Function Consequences of PP2A-B56 Degradation by HIV-1 Vif

STUDY_SECTION: HVCD

STUDY_SECTION_NAME: HIV Molecular Virology, Cell Biology, and Drug Development Study Section[HVCD]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Hematology

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PUBLIC HEALTH RELEVANCE The primary objective of the Trial Design and Biostatistical Support Core is to contribute to the science and operation of the program project by participating fully in its activities. Core Statisticians have broad long- standing expertise in experimental and clinical trial design, data collection, data storage, data analysis, and interpretation of results, incorporating novel and complex statistical procedures as needed. By providing expertise research methodology and logistical support to data analytic activities with each Project, this Core will enhance data interpretation and scientific productivity.

PI_NAMEs: LE, CHAP T. (contact)

PROJECT_TERMS: Acceleration;Animals;Area;Basic Science;Biometry;Biostatistics Core;Blood;Bone Marrow Transplantation;Cell Therapy;Clinical;Clinical Data;Clinical Trials;Clinical Trials Design;Collaborations;Collection;Communities;Complex;Computer software;Consultations;cost effectiveness;Data;Data Analyses;Data Analytics;Data Collection;data management;data sharing;Data Storage and Retrieval;Databases;Dedications;design;Development;Effector Cell;Ensure;Ethics;experience;Experimental Designs;experimental study;Future;Hematologic Neoplasms;Immune;Information Systems;interdisciplinary approach;Knowledge;Location;member;Methodology;Methods;Monitor;novel;operation;Phase;phase II trial;pre-clinical;Procedures;Process;Productivity;Program Development;programs;prospective;Public Health;public health relevance;Publications;quality assurance;Quality Control;Recording of previous events;Reporting;Research;Research Methodology;Research Personnel;Research Support;Resources;Sample Size;Science;Secure;Societies;sound;Statistical Data Interpretation;statistical service;Techniques;Translations;transplantation therapy;trial design


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Pediatric;Racial and Ethnic Minority Health Research

ORG_CITY: CORONA

ORG_NAME: NEW YORK HALL OF SCIENCE

PHR: Project Narrative The proposed project will benefit society by helping Black and Latino youth who live in communities facing multiple, intersecting health inequities, and have most recently been disproportionately affected by COVID-19, to discover how public health professionals contribute to protecting vulnerable communities from future epidemics and pandemics and how they can pursue specific public health- and medicine-focused career pathways. The proposed project will engage the New York Hall of Science with scientists and public health experts from local hospitals and universities, as well as community youth and leaders from a local community-based organization, to collaboratively develop strategies for educating the public about the role of public health in addressing long-standing obstacles to positive health outcomes for Black and Latino populations. The proposed project will create exhibits and programming that can be scaled to a wide variety of informal STEM learning institutions and help broad audiences better understand the roles that they and public health experts can play in mitigating the impact of future health crises in their own communities and in others suffering from poor health outcomes.

PI_NAMEs: CULP, KATHERINE  (contact)

PROGRAM_OFFICER_NAME: BECK, LAWRENCE A

PROJECT_TERMS: Address;Adolescent and Young Adult;Awareness;Basic Science;Black Populations;Black race;career;Career Choice;Career Exploration;collaborative approach;Communities;community engagement;community organizations;COVID-19;COVID-19 impact;COVID-19 pandemic;design;Development;Diagnosis;educational resource development;Educational workshop;Evaluation;Event;Exhibits;Future;future epidemic;future pandemic;Goals;Health;health inequalities;Health Occupations;health outcome disparity;Health Professional;Hospitals;Institution;interest;Knowledge;Latino;Latino Population;Learning;learning outcome;Medicine;member;Methods;Modeling;Monitor;Museums;New York;Outcome;Participant;peer;Persons;Play;poor health outcome;Program Evaluation;programs;prototype;Public Health;public health intervention;Public Participation;recruit;Reduce health disparities;Resources;Role;Science;Science, Technology, Engineering and Mathematics Education;Scientist;Series;Site;Societies;Testing;Trust;Universities;vulnerable community;Youth

PROJECT_TITLE: Preventable Differences: Exploring Public Health Careers with Black and Latino Youth

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(56)R]


ORG_CITY: Aurora

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Lay Summary The annual National MD/PhD Student Conference in Copper Mountain, CO is the only meeting held specifically for MD/PhD students. This 2 ½-day conference brings 5 featured Keynote speakers, many of who are Nobel Laureates, members of the National Academy of Sciences, Howard Hughes Medical Institute Investigators, and from the National Institutes of Health, to interact with the ~190 student attendees who come from across the country. Students present their work in oral and poster sessions, with these renowned Keynote scientists providing critical review of their work, mentorship, and role models. Finally, the conference also incoporates career advising Break Out sessions, Career Panels, and PSTP/RiR Recruitment Fair to optimize the career outcomes of these MD/PhD trainees. Given the national concern regarding the paucity and risk of loss of the physician-scientist, we propose that supporting the MD/PhD students' conference is a valuable and durable investment.

PI_NAMEs: WILSON, CARA C. (contact)

PROGRAM_OFFICER_NAME: BROWN, ANISSA F

PROJECT_TERMS: Address;Administrator;American;Award;Biomedical Research;Caliber;career;Career Choice;career development;Clinical Trials;Colorado;Copper;Country;Degree program;Discipline;Doctor of Philosophy;doctoral student;Electronic Mail;Environment;Facebook;Faculty;feature selection;Food Services;Friendships;Funding;Grant;improved;Industry;Instagram;Institution;Investments;Learning;Medical;meetings;member;men;Mentorship;multidisciplinary;Oral;Outcome;Participant;peer;Physicians;posters;programs;recruit;Reproducibility;Research;Research Ethics;Research Personnel;Residencies;Resort;Risk;role model;Rotation;Science;Scientist;skills;student conference;Students;success;symposium;Training;training opportunity;Training Programs;Travel;Twitter;United States National Academy of Sciences;United States National Institutes of Health;Universities;university student;web site;Woman;Work

PROJECT_TITLE: National MD PhD Student Conference


PHR: PUBLIC HEALTH RELEVANCE This grant focuses on pre-clinical development and clinical implementation of novel third-party Immune Effector Cell (IEC) products in leukemia settings. Core C will serve all of the projects by uniformly integrating sample processing and state-of-the-art analytics for all clinical trials carried out in this grant as well as pre-clinical IEC product evaluation. The resulting high-quality data will be linked to clinical outcomes, in collaboration with Cores A and B, and pre-clinical IEC product functional determination, in collaboration with Core D and Projects, and presented to Project 1, 2, and 3 leaders.

PI_NAMEs: FELICES, MARTIN  (contact)

PROJECT_TERMS: Allogenic;Binding;Biological Assay;Bone Marrow;Cancer Center Support Grant;Cell Physiology;Cell Therapy;Cells;Cellular biology;Clinic;Clinical;Clinical Data;clinical implementation;Clinical Research;Clinical Trials;Collaborations;cytokine;cytokine release syndrome;Cytometry;cytotoxic;Data;Databases;Development;Dose;Drug Kinetics;Effector Cell;Engineering;Engraftment;Evaluation;Funding;Goals;Graft Rejection;graft vs host disease;Grant;Hematologic Neoplasms;Immune;immune reconstitution;immunogenicity;Immunologic Monitoring;Immunologic Tests;Immunotherapeutic agent;Immunotherapy;improved;Individual;Infusion procedures;Ink;Intervention;Laboratories;leukemia;Link;Logic;Mediating;Methodology;migration;Natural Killer Cell Immunotherapy;Natural Killer Cells;neoplastic cell;neutralizing antibody;novel;Outcome;Patients;Pharmacodynamics;pharmacokinetics and pharmacodynamics;Phenotype;Population;pre-clinical;preclinical development;preclinical study;Process;programs;public health relevance;Quality Control;Regulatory T-Lymphocyte;Reproducibility;Resource Sharing;Sampling;Standardization;synergism;T-Lymphocyte;targeted treatment;Techniques;Toxic effect;translational therapeutics;tumor;tumor microenvironment;tumor-immune system interactions;Variant;Work

PROJECT_TITLE: Immune Monitoring Core


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Interstitial Cystitis;Mental Health;Neurosciences;Sleep Research;Urologic Diseases;Women's Health Research

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE Urgency urinary incontinence (UUI) is common in older people and vastly reduces quality of life, yet the cause and mechanism of disease are not well understood. This study will investigate the role of adding behavioral sleep intervention to the standard pharmacotherapy in treatment of UUI among older adults, and the brain mechanisms involved in continence by evaluating brain changes. This will expand our current knowledge of how the sleep affects bladder control, and better characterize the brain mechanisms in maintaining continence.

PI_NAMEs: TYAGI, SHACHI  (contact)

PROGRAM_OFFICER_NAME: NELLISSERY, MAGGIE JACOB

PROJECT_TERMS: Address;Adherence;adherence rate;Adrenergic Receptor;Affect;aged;Agonist;Anxiety;Anxiety Disorders;Attention;attentional control;Behavior Therapy;behavioral sleep intervention;Biofeedback;Bladder;Bladder Control;Brain;brain based;brain pathway;Caring;Clinical;cognitive task;Combined Modality Therapy;Comorbid Insomnia;Complement;Complex;cost;Data;debilitating symptom;design;Development;Disease;Etiology;evidence base;executive function;Frequencies;Goals;holistic approach;Hour;human old age (65+);Impairment;improved;improved outcome;improvement on sleep;Incontinence;incontinence symptom;insight;Intervention;Knowledge;Link;lower urinary tract symptoms;Medial;Mediating;Mediator;medication compliance;micturition urgency;Modeling;multiple chronic conditions;Muscarinics;neural;Nocturia;novel;novel therapeutics;older adult;Older Population;older women;Overactive Bladder;Pathway interactions;Patients;Pelvic Floor Muscle;Peripheral;Pharmaceutical Preparations;Pharmacotherapy;Play;poor sleep;post intervention;Prefrontal Cortex;primary endpoint;primary outcome;Quality of life;Randomized;Randomized, Controlled Trials;Reporting;response;Risk;Role;Secondary to;side effect;Sleep;Sleep Deprivation;Sleep disturbances;Sleeplessness;Spasm;standard of care;success;Symptoms;targeted treatment;Therapeutic;treatment effect;treatment response;Urinary Incontinence;Woman

PROJECT_TITLE: Sleep and Bladder Study

STUDY_SECTION: KUFD

STUDY_SECTION_NAME: Kidney and Urological Systems Function and Dysfunction Study Section[KUFD]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Genetics

ORG_CITY: HOUSTON

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: RICE UNIVERSITY

ORG_STATE: TX

PHR: Project Narrative DNA is the blueprint of human and mutations on DNA can cause genetic diseases and cancer. This project aims to illustrate how the protein machineries that copy genomic DNA are constructed at atomic level and how disfunction of these machineries may lead to genetic mutations and human diseases.

PI_NAMEs: GAO, YANG  (contact)

PROGRAM_OFFICER_NAME: REDDY, MICHAEL K

PROJECT_TERMS: assault;Bacteriophage T7;Biochemical;biological adaptation to stress;Biological Models;Cells;Coupled;Cryoelectron Microscopy;Development;DNA;DNA biosynthesis;DNA Maintenance;DNA Repair;DNA Sequence Alteration;Functional disorder;Genetic Diseases;Genetic Variation;Genome;Genomic DNA;Health;Human;human disease;Human Genetics;Investigation;Lead;Life;Malignant Neoplasms;Mediating;Mitochondria;Mitochondrial DNA;Multiprotein Complexes;Mutation;novel therapeutics;operation;Play;Proteins;reconstitution;repaired;replication stress;response;Role;Signal Transduction;Stress;Structure

PROJECT_TITLE: Structural basis of replisome mediated DNA replication and repair

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-I(55)R]


NIH_SPENDING_CATS: Biotechnology;Cancer;Childhood Leukemia;Gene Therapy;Genetics;Hematology;Immunotherapy;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PHR: PUBLIC HEALTH RELEVANCE The creation of safer and more effective off-the-shelf immune effector cells targeting cancer is highly relevant to public health. T regulatory cells (Treg), NK cells and induced pluripotent stem cell (iPSC)-Tregs are alternatives to conventional T cells. Core D produces molecular reagents, provides molecular monitoring of cells, and distributes cell populations, novel peptides (e.g., nanobodies) and constructing nucleic acid elements (e.g., CARs, CRISPR/Cas9/base/gene targeting reagents etc.) for delivery to cells as outlined in the 3 Projects.

PI_NAMEs: OSBORN, MARK J (contact)

PROJECT_TERMS: Acute leukemia;Acute Lymphocytic Leukemia;Acute Myelocytic Leukemia;adeno-associated viral vector;Adverse event;Affinity;Allogenic;Antigens;base;base editing;cancer therapy;CD8B1 gene;Cell Line;Cell Physiology;Cells;cellular engineering;chimeric antigen receptor;Clinical;clinical implementation;Clinical Trials;Cloning;Cluster Analysis;Collaborations;Comparative Study;Custom;Data;Databases;Dependovirus;Development;DNA;Effector Cell;Elements;Engineering;Ensure;experimental study;FOXP3 gene;gene editing technology;Gene Targeting;gene therapy;Generations;Genes;Genetic;Genetic Engineering;Genetic Transcription;Genome engineering;genomic locus;Globulins;Goals;graft vs host disease;Hematologic Neoplasms;Image;Immune;Immune response;immunoengineering;Immunotherapeutic agent;Immunotherapy;improved;In Vitro;Individual;induced pluripotent stem cell;Intervention;Laboratories;Lentivirus;leukemia;Luciferases;Malignant Neoplasms;MHC class II transactivator protein;Modification;Molecular;Molecular Analysis;Monitor;nanobodies;Natural Killer Cells;novel;Nucleic Acids;Outcome;overexpression;particle;Peer Review;Peptides;peripheral blood;Population;prime editing;Production;programs;Property;Protein Engineering;Proteins;Protocols documentation;Public Health;public health relevance;Quality Control;Reagent;Regulatory T-Lymphocyte;repaired;Reproducibility;Review Literature;Risk;RUNX3 gene;Safety;Serotyping;Standardization;statistics;synergism;T-Lymphocyte;Target Populations;Testing;Therapeutic;Time;tool;transcriptome;tumor;tumor eradication;Umbilical Cord Blood;Up-Regulation;Validation;Variant;vector;Viral;Viral Vector;Virus-like particle

PROJECT_TITLE: Cell and Genome Engineering Core


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Data Science;Emerging Infectious Diseases;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Rare Diseases;Vector-Borne Diseases;Zika Virus

ORG_CITY: LOS ANGELES

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: Project Narrative Tracking and predicting viral outbreaks remains an open epidemiological problem with deadly consequences. Dr. Holbrook will attack the problem with his Bayesian phylogenetic Hawkes processes, a class of models tailored to simultaneously reconstruct evolutionary histories and predict viral diffusion dynamics. With the mentorship of Profs. Marc Suchard (primary) and Kristian Andersen (secondary), Dr. Holbrook will develop open-source, high-performance computing software and apply his statistical computing methodology to the analysis of the 2015-2016 Zika virus epidemic of the Americas, learning key routes of transmission and identifying phylogenetic clades with enhanced infectiousness.

PI_NAMEs: HOLBROOK, ANDREW JAMES (contact)

PROGRAM_OFFICER_NAME: GAUTAM, RAJEEV

PROJECT_TERMS: Accounting;Address;Adoption;Air;Alzheimer's Disease;Americas;Award;Bayesian learning;Bayesian Modeling;Behavior;Big Data;Biological;Biology;blind;career development;Collaborations;Complex;Computer Models;Computer software;Computing Methodologies;Dangerousness;Data;Data Analyses;Data Science;Data Set;Development;Development Plans;Diffusion;Dimensions;Disease Outbreaks;Doctor of Medicine;Doctor of Philosophy;Earthquakes;Epidemic;epidemic virus;epidemiological model;Epidemiologist;Epidemiology;Evaluation;Event;Evolution;Faculty;Failure;flexibility;Free Will;Generations;Geography;Goals;Health;Herd Immunity;High Performance Computing;Human Genetics;Individual;Influenza;innovation;insight;invention;Investigation;Joints;Knowledge;Lead;Learning;Mathematics;Medical;meetings;Mentors;Mentorship;Methodology;Modeling;novel;open source;outbreak prediction;parallel computer;pathogen;Pattern;Performance;Phylogenetic Analysis;Phylogeny;Policy Maker;Postdoctoral Fellow;Process;Publications;Publishing;reconstruction;Recording of previous events;Research;response;Route;Schedule;Scientist;Ships;Speed;Statistical Computing;statistics;Stochastic Processes;Structure;Techniques;Testing;Time;transmission process;Travel;Viral;Viral Epidemiology;viral outbreak;Viral Physiology;Work;ZIKA;Zika Virus

PROJECT_TITLE: Big Data Predictive Phylogenetics with Bayesian Learning

STUDY_SECTION_NAME: Microbiology and Infectious Diseases B Research Study Section[MID-B]


NIH_SPENDING_CATS: Aging;Bioengineering;Brain Disorders;Cerebrovascular;Clinical Research;Disability Research;Emergency Care;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Hematology;Neurosciences;Prevention;Social Determinants of Health;Stroke

ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: PROJECT NARRATIVE Ischemic stroke is leading cause of disability in the US and large vessel occlusion (LVO) comprises the majority of strokes with poor outcomes. The current stroke care relies on EMS triage systems to facilitate access to timely high-quality emergency care for Intravenous thrombolysis therapy (IVT) but not for Endovascular therapy EVT, the most effective treatment for LVO. We propose to develop an innovative, reproducible geospatial algorithm of stroke triage that maximizes neurological recovery for all stroke patients in the US and that can be integrated in a point-of-care decision support application for easy use by paramedics.

PI_NAMEs: BROWN, GRANT D;MOHR, NICHOLAS M.;ORTEGA-GUTIERREZ, SANTIAGO  (contact)

PROGRAM_OFFICER_NAME: JANIS, SCOTT

PROJECT_TERMS: Acute;Address;Algorithms;American;Area;Bayesian Modeling;Bypass;Caring;Cessation of life;Characteristics;Clinical;Clinical Trials;Communities;Costs and Benefits;Data;Decision Analysis;Decision Making;Decision Trees;design;Destinations;Development;Diagnostic;diagnostic accuracy;diagnostic tool;disability;Disability disparity;Disparity;Early treatment;effective therapy;Eligibility Determination;Emergency Care;Emergency medical service;ethnic minority;Evaluation;evidence base;experience;Fostering;Foundations;Future;geographic disparity;Geography;Guidelines;Health system;Healthcare;Hospitals;improved;Individual;individual patient;ineffective therapies;innovation;Interdisciplinary Study;Intravenous;Ischemic Stroke;Lead;Link;Location;Long term disability;metropolitan;mobile application;Modeling;Modification;Morbidity - disease rate;mortality;Neurological outcome;neurological recovery;novel therapeutic intervention;operation;Outcome;outcome disparities;outcome prediction;Paramedical Personnel;Pathway interactions;Patient-Focused Outcomes;Patients;point of care;Population;prevent;Prevention;Probability;Qualifying;racial disparity;randomized trial;Randomized, Controlled Trials;rapid diagnosis;Recommendation;Registries;Reperfusion Therapy;Reproducibility;Research;Resources;Risk;Rural;rural area;Severities;Spain;Stroke;stroke model;stroke outcome;stroke patient;Stroke prevention;Structure;suburb;support tools;System;Telemedicine;Testing;Therapeutic;thrombolysis;Time;tool;Triage;Uncertainty;United States

PROJECT_TITLE: Geospatial modeling for stroke care

STUDY_SECTION: CDMA

STUDY_SECTION_NAME: Clinical Data Management and Analysis Study Section[CDMA]


ORG_CITY: WASHINGTON

ORG_NAME: GEORGE WASHINGTON UNIVERSITY

ORG_STATE: DC

PHR: Narrative  This proposal focuses on learning how anti-HIV drugs and small immune cells known as platelets stimulate abnormal changes in monocytes causing small vessel damage in the brain and neurologic illness during HIV infection. This new information regarding how these cells determine the fate of blood vessel walls is expected to improve therapies against brain disease processes in the general population, as well as those affected by HIV infection.

PI_NAMEs: MAGGIRWAR, SANJAY B. (contact)

PROGRAM_OFFICER_NAME: DALEY, WILLIAM PATRICK

PROJECT_TERMS: 3-Dimensional;Adhesions;Affect;Anti-HIV Agents;Antibodies;antiretroviral therapy;astrogliosis;axon injury;Blood - brain barrier anatomy;Blood brain barrier dysfunction;Blood Platelets;Blood Vessels;Brain;Brain Diseases;brain endothelial cell;Cell Adhesion Molecules;Cell Differentiation process;Cells;Central Nervous System;Characteristics;Chronic;Circulation;Clonal Expansion;cognitive ability;Data;demethylation;Dioxygenases;DNA Methylation;DNA Modification Methylases;Endothelium;Epigenetic Process;Event;Exhibits;experimental study;Exposure to;Extravasation;Gene Expression;gene product;General Population;Genes;glial activation;Goals;Hematopoiesis;Heterogeneity;HIV;HIV Infections;HIV Seronegativity;HIV Seropositivity;HIV-1;Human;Immune;Impaired cognition;improved;Individual;Infiltration;Inflammatory;Injury;Integrins;Intercellular adhesion molecule 1;JAK2 gene;Learning;Literature;Macrophage;Measures;Mediating;migration;Modeling;Monoclonal Antibodies;monocyte;monolayer;mouse model;Mus;Myeloid Cells;Nervous System Trauma;neuroinflammation;Neurologic;Neurologic Symptoms;Neuronal Dysfunction;neuroregulation;novel;P-Selectin;P-selectin ligand protein;Phenotype;Physiological;Play;Process;promoter;Promoter Regions;Proto-Oncogene Proteins c-myc;response;Role;Secondary to;shear stress;Site;Sorting;Testing;Tetanus Helper Peptide;Time;Vascular Cell Adhesion Molecule-1;Wild Type Mouse

PROJECT_TITLE: Clonal hematopoiesis in monocytes contributes to HIV-associated neuroinflammation


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Heart Disease;Physical Activity;Rare Diseases;Rehabilitation

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Project Narrative Transthyretin cardiac amyloidosis causes debilitating heart failure in older adults. The proposed research will develop a personalized exercise training program to improve functional capacity in patients on optimal treatment for transthyretin cardiac amyloidosis. This is a vital next step to improve functional capacity and quality of life of people suffering from transthyretin cardiac amyloidosis.

PI_NAMEs: CUDDY, SARAH AM (contact)

PROGRAM_OFFICER_NAME: WOO, SEUNG KYOON

PROJECT_TERMS: Activities of Daily Living;Adult;Advisory Committees;Aerobic;Affect;Age;Aging;aging related disease;American;Amyloidosis;Award;Biology of Aging;Boston;Cardiac;cardiac amyloidosis;Cardiomyopathies;Cardiopulmonary;career;career development;Cities;Clinical;cohort;Control Groups;cost;Data;design;Disease;Disease Progression;EFRAC;Enrollment;Evaluation;exercise intervention;exercise intolerance;exercise program;Exercise Test;exercise training;Extensor;Functional disorder;Future;Goals;Heart failure;heart imaging;Hospitalization;Hospitals;human old age (65+);Image;improved;instructor;Investments;Kansas;Knowledge;Left;Leg;Life;Lower Extremity;Measures;medical schools;Medicine;Mentors;Mentorship;Morbidity - disease rate;mortality;Muscle;Musculoskeletal;Myocardial dysfunction;neuromuscular;novel;older adult;older patient;optimal treatments;Patients;Performance;personalized strategies;Persons;Physical Performance;Physicians;Population;Prealbumin;preservation;Program Development;Progressive Disease;Prospective Studies;Proteins;Protocols documentation;Publications;Qualifying;Quality of life;Questionnaires;Randomized, Controlled Trials;Research;Research Personnel;response;Scientist;Severities;sex;Skeletal Muscle;skills;Systemic disease;Therapeutic Intervention;Therapeutic Trials;therapy development;Thick;Training Programs;Treatment Failure;Ventricular;VO2max;Woman;Work

PROJECT_TITLE: Personalized Exercise Training to Improve Functional Capacity in Transthyretin Cardiac Amyloidosis

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(OA)]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: RELEVANCE:  Transcranial Magnetic Stimulation (TMS) is widely used and safe technique for non-invasive modulation of human brain activity with several FDA-approved clinical applications. However, most diagnostic and therapeutic applications of TMS administer the stimulation to a single brain region. This proposal addresses the currently unmet need for non-invasive mapping of the causal roles of multiple cortical areas participating in network-level cognitive functions such as hearing, speech, and language processing.

PI_NAMEs: NUMMENMAA, AAPO  (contact)

PROGRAM_OFFICER_NAME: SABRI, MERAV

PROJECT_TERMS: Address;Algorithms;Anterior;Area;Behavior;Behavioral;Bilateral;Brain;Brain Mapping;Brain region;clinical application;Cognition;Cognitive;cognitive function;cognitive neuroscience;Complex;Computer Models;computerized data processing;computerized tools;Computing Methodologies;Consumption;cortex mapping;Custom;Data;Devices;Diagnostic;Dorsal;electric field;Electroencephalography;Experimental Designs;experimental study;FDA approved;Freedom;Functional Magnetic Resonance Imaging;Generations;Goals;Head;Hearing;Human;in vivo;Inferior frontal gyrus;insight;instrument;Judgment;Language;language comprehension;language processing;Left;Lesion;Location;Magnetic Resonance Imaging;Maps;Methods;millisecond;Modeling;Motor;Motor Cortex;network models;neural;neural network;neuroimaging;neuronal circuitry;Neuronavigation;Neurosciences;novel;novel strategies;operation;Participant;Patients;Pattern;phonology;Population;Procedures;Protocols documentation;Research;response;Response Latencies;Role;semantic processing;Semantics;Societies;sound;speech processing;Standardization;Statistical Models;success;support network;Synaptic plasticity;Synaptic Transmission;System;Techniques;Technology;Testing;Therapeutic;Time;tool;Transcranial magnetic stimulation;treatment optimization;virtual;Work

PROJECT_TITLE: CRCNS: Multifocal causal mapping of brain networks supporting human cognition


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: Chatham

ORG_NAME: ALLIED INNOVATIVE SYSTEMS, LLC

ORG_STATE: NJ

PHR: Narrative The development of the proposed method will allow using highly sensitive tests for detection of low concentrations of biomarkers for various neurodegenerative diseases. The performance of the developed tests will be improved significantly compared to conventional assays. Successful completion of these studies will be beneficial for public health and make available all the technology needed for a substantial business opportunity to license the technology and manufacture commercial products.

PI_NAMEs: BYSTRYAK, SIMON  (contact)

PROGRAM_OFFICER_NAME: RADOJA, NADEZDA

PROJECT_TERMS: Achievement;Affect;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer’s disease biomarker;Amyloid beta-42;analytical method;Antibodies;antibody detection;Bacteria;Binding;Biochemical Reaction;Biological Assay;Biological Markers;Biology;Blood;Blood specimen;Brain-Derived Neurotrophic Factor;brain-derived neurotrophic factor precursor;Businesses;Cerebrospinal Fluid;Clinical;Complex;Coronavirus;cost;cost effective;cytokine;design;Detection;detection assay;detection method;detection platform;detection test;Development;Devices;Diagnosis;Diagnostic;Diagnostic Reagent Kits;Disease;Drug Screening;early detection biomarkers;Enzyme-Linked Immunosorbent Assay;Enzymes;European;Evaluation Studies;Goals;Horseradish Peroxidase;Immune System Diseases;Immunoassay;improved;innovation;interest;Interleukins;Label;laboratory equipment;Legal patent;Licensing;Lighting;Malignant Neoplasms;Manuals;manufacture;Measures;Mediating;Medicine;Methods;Monitor;Neurodegenerative Disorders;Neurofibrillary Tangles;new technology;Peptides;Performance;Phase;Plasma;Process;Production;Property;Proteins;Public Health;Reaction;Reagent;Research;Sampling;Secure;Serum;Signal Transduction;Solid;success;System;tau Proteins;tau-1;Technology;Testing;Time;viral detection;Visible Radiation

PROJECT_TITLE: Highly sensitive immunoassay for determination of biomarkers for neurodegenerative diseases

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-NV-G(13)B]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Infectious Diseases;Influenza;Lung;Pediatric;Pneumonia;Pneumonia and Influenza

ORG_CITY: CHICAGO

ORG_NAME: LURIE CHILDREN'S HOSPITAL OF CHICAGO

ORG_STATE: IL

PHR: Project Narrative: Influenza A virus (IAV) is a highly contagious virus that causes life-threatening pneumonia in children. While necessary for early control of viral replication, excessive type I interferon signaling may exacerbate IAV-induced respiratory failure in children. We aim to identify mechanisms underlying type I interferon-induced inflammation that will lead to new therapeutic options for children infected with IAV.

PI_NAMEs: COATES, BRIA M (contact)

PROGRAM_OFFICER_NAME: NATARAJAN, ARUNA R

PROJECT_TERMS: 5 year old;Address;Admission activity;Adolescent;Adoptive Transfer;Adult;Age;age difference;age related changes;alveolar epithelium;Alveolar Macrophages;Alveolus;Animal Model;Anti-viral Agents;Anti-viral Response;Automobile Driving;Bioinformatics;Bronchoalveolar Lavage Fluid;CCL2 gene;Cell model;Cells;chemokine;Child;Childhood;clinically relevant;comorbidity;Credentialing;Data;design;Dimensions;Disease;Epithelial Cells;epithelial repair;Failure;Flow Cytometry;Gene Expression Profiling;Genetic;Goals;Hospitalization;IFNAR1 gene;Immune response;Immune signaling;Impairment;improved;improved outcome;Inflammasome;Inflammation;Inflammatory;Inflammatory Response;Influenza;Influenza A virus;influenza infection;influenza pneumonia;Injury;Interferon Type I;Life;Lung;lung injury;Macrophage;mature animal;Mediating;Modeling;monocyte;mortality;mouse model;Mus;novel therapeutic intervention;novel therapeutics;Pathogenesis;Pathway interactions;Pediatric Intensive Care Units;pharmacologic;Phenotype;Pneumonia;Positioning Attribute;Predisposition;Production;Recovery;recruit;Research;Respiratory Failure;respiratory virus;response;Risk;Role;Sampling;Scientist;Severity of illness;Signal Transduction;Structure of mucous membrane of nose;Supportive care;Testing;Therapeutic;therapeutic target;type I interferon receptor;Up-Regulation;Viral;Viral Load result;Viral Pneumonia;Viral Respiratory Tract Infection;Virus;Virus Diseases;Virus Replication

PROJECT_TITLE: Elucidating the role of type I interferon signaling and macrophage-derived inflammation in the juvenile host with viral pneumonia

STUDY_SECTION: LIRR

STUDY_SECTION_NAME: Lung Injury, Repair, and Remodeling Study Section[LIRR]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Lung;Pediatric;Pediatric - AIDS;Prevention;Rare Diseases;Tuberculosis

ORG_CITY: Stellenbosch

ORG_COUNTRY: SOUTH AFRICA

ORG_FIPS: SF

ORG_NAME: STELLENBOSCH UNIVERSITY

PHR: PROJECT NARRATIVE Young children and those living with HIV are at the highest risk of progressing from Mtb exposure to tuberculosis (TB) disease and of developing severe forms of TB. We will use stored samples from young children already recruited to longitudinal clinical TB studies in South Africa and use transcriptomics, proteomics, metabolomics, and antibody approaches to identify biomarkers associated with progression to TB disease and treatment response. We will integrate the different approaches, together with information on viral coinfection and clinical and epidemiological covariates, to identify the optimal signatures to allow targeted TB preventive therapy.

PI_NAMEs: SEDDON, JAMES ALEXANDER (contact)

PROGRAM_OFFICER_NAME: LOMBO RODRIGUEZ, TANIA

PROJECT_TERMS: 5 year old;Adult;Affect;Age;Antibodies;Antitubercular Agents;Bacille Calmette-Guerin vaccination;Bacillus;Bacteria;Bioinformatics;Biological;Biological Markers;Biology;biomarker identification;biomarker signature;biosignature;Cessation of life;Child;Childhood;Classification;Clinical;clinical epidemiology;Clinical Research;clinical translation;clinically relevant;co-infection;cohort;Collection;cost;Cross-Sectional Studies;Cytomegalovirus;Data;Data Collection;design;Development;Diagnostic;Disease;disease classification;Disease Progression;Drug resistance in tuberculosis;epidemiologic data;Epidemiology;Exposure to;Family;Future;Goals;Health Services;high risk;HIV;HIV/TB;Household;Immunologic Sensitization;Immunologics;Immunology;Immunology procedure;Individual;Infection;insight;Longitudinal cohort;Mass Spectrum Analysis;Meningeal Tuberculosis;Metabolic;metabolomics;Methods;Morbidity - disease rate;mortality;Mycobacterium tuberculosis;Nested Case-Control Study;novel marker;Nutritional status;Organism;overtreatment;pathogen;pathogenic virus;Pathway Analysis;Pediatrics;Performance;Population;Positioning Attribute;predictive marker;predictive signature;prevent;Prevention;Preventive therapy;progression risk;prospective;Proteomics;Recommendation;recruit;repository;Research;response;Risk;Sampling;Scientist;Serology;South Africa;Subgroup;System;Testing;Therapy trial;Time;Toxic effect;Training;transcriptomics;treatment response;Tuberculosis;tuberculosis treatment;Viral;Virus;Virus Diseases

PROJECT_TITLE: Identifying correlates of risk for future tuberculosis disease progression in children (INTREPID)


NIH_SPENDING_CATS: Hematology;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: Project Narrative: Effective treatment for hematological malignancies and blood cancers remains an outstanding open problem. The only existing cure for most blood disorders is bone marrow transplant, which is only feasible for a minority of patients and has poor prognosis. The work proposed here will provide fundamental new insights into the process of birth of blood forming stem cells, which will help with the production and manipulation of these cells.

PI_NAMEs: CAMARGO, FERNANDO  (contact);HORMOZ, SAHAND

PROGRAM_OFFICER_NAME: BAI, C BRIAN

PROJECT_TERMS: Ablation;Adult;Age;Aging;Anatomy;Aorta;Arteries;Bar Codes;Biology;Birth;Blood;Blood Cells;Bone Marrow Transplantation;Cell Lineage;Cell Ontogeny;cell type;Cells;Characteristics;Clustered Regularly Interspaced Short Palindromic Repeats;Data;Development;Developmental Biology;Dissociation;effective therapy;Embryo;embryo cell;Endothelial Cells;Endothelium;Epigenetic Process;Event;experimental study;Goals;Growth;Hematologic Neoplasms;Hematological Disease;Hematopoiesis;Hematopoietic;Hematopoietic Neoplasms;Hematopoietic Stem Cell Specification;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;Heterogeneity;improved;In Situ;In Vitro;insight;Laboratories;Link;Mammals;Maps;Minority;Modeling;Molecular;multiple omics;Multipotent Stem Cells;Neonatal;Patients;Phenotype;Physiological;Population;population based;postnatal;premature;Process;Production;Prognosis;recruit;Resolution;Site;Source;stem cell fate specification;stem cell population;Stress;System;Testing;Therapeutic;Time;Tissues;tool;Transplantation;Work;Yolk Sac;young adult

PROJECT_TITLE: High resolution lineage tracing of developmental hematopoiesis

STUDY_SECTION_NAME: Development - 2 Study Section[DEV2]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Dietary Supplements;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Nutrition;Obesity;Prevention;Racial and Ethnic Minority Health Research

ORG_CITY: KANSAS CITY

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: PROJECTIVE NARRATIVE African Americans experience higher rates of Alzheimer's disease (AD) in which half of the cases are a result of risk factors that can be modified by diet. However, limited research has specifically focused on the development of culturally tailored dietary strategies aimed to reduce the risk of AD among older African Americans. This study will (1) design an adapted brain-healthy soul food diet intervention by identifying the cultural context under which a brain-healthy diet is perceived and practiced among African Americans; (2) use a community-based approach to pilot test an adapted brain-healthy soul food diet intervention; (3) explore the effect of adapted brain-healthy soul food diet intervention on cognitive function as preliminary data to design an RCT.

PI_NAMEs: SHAW, ASHLEY RICHELLE (contact)

PROGRAM_OFFICER_NAME: WAGSTER, MOLLY V

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;Adult;Affect;African American;African American population;age effect;age-related disease;Alzheimer's Disease;Alzheimer's disease risk;Area;Attitude;Behavior;Behavioral;Biological Markers;Blood Pressure;Body Composition;Body fat;Brain;brain health;Burn injury;cardiovascular risk factor;career development;Career Mobility;Caucasians;Cause of Death;Cholesterol;Chronic;Clinical Trials Design;Cognition;cognitive function;cognitive testing;Communities;community based research;community engaged approach;Consumption;cultural values;culturally appropriate intervention;DASH diet;Data;design;Development;Diabetes Mellitus;Diet;dietary;dietary adherence;Dietary Intervention;Dietary Practices;Disease;Disparity;effective intervention;efficacy testing;Environment;ethnic minority;Evaluation;experience;Focus Groups;Food;Food Preferences;Geographic Locations;Goals;good diet;Health Status;High Prevalence;Impaired cognition;improved;information gathering;Intervention;Knowledge;Life Style;lifestyle intervention;Mediterranean Diet;Mentored Research Scientist Development Award;Mentors;Mentorship;modifiable risk;Nerve Degeneration;Not Hispanic or Latino;nutrition education;Nutritional;Obesity;Outcome;Participant;personalized approach;Pilot Projects;pilot test;Play;prevent;Prevention strategy;Public Health;racial minority;Recommendation;Reporting;Research;Research Design;Research Methodology;Research Personnel;Resources;Risk;Risk Factors;Risk Reduction;Role;skills;Surveys;Testing;therapy design;therapy development;Training;Work

PROJECT_TITLE: Brain Healthy Soul Food Diet Intervention Among Older African Americans

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Behavior and Social Science of Aging Study Section[NIA-S]


ORG_DEPT: PHYSIOLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: Project Narrative The mechanisms underlying the degeneration of substantia nigra dopaminergic (SN DAergic) neurons and the emergence of abnormal brain activity and movement deficits in Parkinson’s disease (PD) remain poorly understood. To help fill this gap, we propose to study the progression of brain circuit and motor dysfunction in a genetic mouse model of PD that mimics the pattern of DA loss in humans. Through this research, we hope to understand why brain function is initially resilient to–but ultimately dysregulated by–the degeneration of SN DAergic neurons, and whether correction of abnormal circuit activity at early or more advanced stages of parkinsonism can rescue movement and/or prevent further neurodegeneration.

PI_NAMEs: BEVAN, MARK D (contact)

PROGRAM_OFFICER_NAME: SIEBER, BETH-ANNE

PROJECT_TERMS: Acceleration;Acute;Axon;Basal Ganglia;Behavioral;Bioenergetics;Bradykinesia;Brain;brain abnormalities;Cells;Chronic;Cognitive deficits;Corpus striatum structure;Data;Diagnosis;Disease;dopaminergic neuron;Dorsal;Electrophysiology (science);Exhibits;Functional disorder;Genetic;genetic approach;genetic manipulation;Human;Image;in vivo;Learning;Levodopa;Link;Masks;Membrane;Methods;Mitochondria;mitochondrial dysfunction;mitopark mouse;Modeling;Motor;motor deficit;motor disorder;mouse model;Movement;Mus;Nerve Degeneration;Neurons;Nuclear;optogenetics;Parkinson Disease;Parkinsonian Disorders;Pathway interactions;Patients;Pattern;Predisposition;Presynaptic Terminals;prevent;Property;Research;Residual state;resilience;Source;spatiotemporal;Stress;Substantia nigra structure;Symptoms;Synapses;Testing;Time;Toxin;transcription factor;transmission process;two-photon;Ventral Tegmental Area

PROJECT_TITLE: Resilience, Dysregulation, and Rescue of Basal Ganglia Indirect Pathway Function in Progressive Parkinsonism

STUDY_SECTION: SMN

STUDY_SECTION_NAME: Sensory-Motor Neuroscience Study Section[SMN]


NIH_SPENDING_CATS: Neurosciences

ORG_DEPT: NEUROSCIENCES

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Optical methods are a primary technique for the study of cellular physiology. This research concerns the development of new optical probes that will enable photocontrol of membrane excitability in vitro and in vivo. Since almost all cell signaling is bidirectional or symbiotic, these new methods will revolutionize our ability to control function and therefore uncover many fresh details of cell physiology.

PI_NAMEs: ELLIS-DAVIES, GRAHAM  (contact)

PROGRAM_OFFICER_NAME: UMANAH, GEORGE KWABENA ESSIEN

PROJECT_TITLE: Light-Driven Control of Neurons in Vitro and in Vivo


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Estrogen;Neurosciences;Opioids;Substance Misuse

ORG_CITY: TEMPE

ORG_DEPT: PSYCHOLOGY

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

ORG_STATE: AZ

PHR: PROJECT NARRATIVE / PUBLIC HEALTH RELEVANCE The goal of the studies outlined in this proposal is to explore the neural circuits utilizing pro-opiomelanocortin (POMC) derived peptides in regulating binge-like ethanol intake as well as sex differences in ethanol consumption. These studies will provide novel information on the mechanisms by which binge-like ethanol intake engages and is regulated by components of the endogenous opioid system. Information gained from this line of research will ultimately guide the development of neuromodulatory or other types of approaches for reducing binge-like ethanol intake, which may reduce the medical, socioeconomic and legal costs of alcohol abuse to society.

PI_NAMEs: OLIVE, M. FOSTER (contact)

PROGRAM_OFFICER_NAME: LIU, QI-YING

PROJECT_TERMS: Agonist;Alcohol abuse;alcohol abuse therapy;Alcohol consumption;alcohol effect;alcohol use disorder;Amygdaloid structure;Animals;Bathing;beta-Endorphin;Brain;Cannulas;Cells;clinical efficacy;Consumption;cost;craving;design;designer receptors exclusively activated by designer drugs;Development;dopaminergic neuron;Electric Capacitance;Electrophysiology (science);endogenous opioids;ESR1 gene;Estradiol;Ethanol;Female;female sex hormone;Frequencies;Genes;Genetic;Glutamates;Goals;Hormone Receptor;Hypothalamic structure;Immunohistochemistry;implantation;improved;Infusion procedures;Intake;Label;Legal;male;Mediating;Medical;Membrane Potentials;Midbrain structure;Morphology;Motivation;Mus;nalmefene;Naltrexone;Nature;neural circuit;neurochemistry;neuronal excitability;Neurons;Neuropeptides;neurophysiology;neuroregulation;novel;Nucleus Accumbens;Opioid;Opioid Antagonist;Opioid Peptide;patch clamp;Peptides;pharmacologic;Phenotype;Physiological;Pro-Opiomelanocortin;Procedures;Progesterone Receptors;Property;public health relevance;receptor;Regulation;Relapse;Research;retrograde transport;reward circuitry;Rewards;Role;sex;Sex Differences;Site;Societies;socioeconomics;Structure of nucleus infundibularis hypothalami;System;Testing;Ventral Tegmental Area;Viral Vector;α-Melanocyte stimulating hormone

PROJECT_TITLE: Regulation of binge-like ethanol intake by arcuate POMC projection neurons

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Physical Activity;Prevention

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE The overarching goal of this proposal is to better understand the biological and behavioral processes that support sustained cognitive resilience to brain aging. Successful completion of our collaborative project will more precisely determine the role of synaptic integrity and physical activity as candidate therapeutic targets to help prevent and slow Alzheimer's disease and related dementias (ADRD).

PI_NAMEs: CASALETTO, KAITLIN B (contact)

PROJECT_TERMS: actigraphy;Address;Adult;Adverse effects;aged;Aging;aging brain;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Alzheimer’s disease biomarker;American;Amyloid;Animal Experiments;Animals;Attenuated;Autopsy;autosome;Behavior;Behavioral;Biological;Biological Markers;Biology;Brain;brain magnetic resonance imaging;Brain Pathology;brain tissue;Calcium;Calcium Signaling;Cell Adhesion;Cerebrospinal Fluid;Cerebrospinal Fluid Proteins;Cessation of life;Clinical;clinically relevant;Cognition;Cognitive;Cognitive aging;cognitive performance;cohort;Collaborations;Communication;Coupled;Cytoskeleton;Data;Decision Making;Dementia;design;Development;Dissection;Dominant Genetic Conditions;emerging adult;end of life;Etiology;Evaluation;Exercise;Frequencies;Goals;Health;Heterogeneity;Human;Human Biology;human old age (65+);Impaired cognition;indexing;Individual;Infarction;innovation;Life;Life Style;Link;Liquid substance;Machine Learning;machine learning model;Maintenance;Mass Spectrum Analysis;Measurement;Measures;Memory;Modeling;Molecular;Monitor;Movement;Nature;neural;neurobehavioral;neurogranin;neuronal pentraxin;neuropathology;Neurotransmitters;older adult;Participant;Pathology;Persons;Physical activity;postsynaptic;preservation;presynaptic;prevent;Process;programs;promote resilience;prospective;protective factors;protein biomarkers;Proteins;Publishing;receptor;Research;Residual state;resilience;Resources;Role;Sampling;Signal Transduction;Symptoms;Synapses;synaptic function;tau Proteins;Techniques;Technology;theories;therapeutic candidate;therapeutic target;Time;Tissue Sample;Vesicle;Work

PROJECT_TITLE: Unraveling the intersection of synaptic biology, lifestyle, and cognitive resilience

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Liver Disease;Nutrition;Obesity;Rare Diseases

ORG_NAME: UNIVERSITY OF MINNESOTA

PHR: This project will define the 11S-associated immunoproteasome as a key molecular factor that mediates high fat diet-induced steatosis, obesity and related pathologies. Successful completion of the project will establish the 11S-associated immunoproteasome as a promising therapeutic target for obesity-related metabolic disorderes.

PI_NAMEs: KIM, DO-HYUNG  (contact)

PROGRAM_OFFICER_NAME: SECHI, SALVATORE

PROJECT_TERMS: Address;aged;Aging;Anti-Inflammatory Agents;Autoimmune Diseases;Binding Proteins;Biochemical;Biogenesis;biological adaptation to stress;Catalytic Domain;Cell Culture Techniques;Cell model;Cells;Chronic;Chronic Active Hepatitis;Cirrhosis;Complex;Degradation Pathway;Diabetes Mellitus;diet-induced obesity;Digestion;Disease;Energy Metabolism;experience;fatty acid oxidation;Fatty Liver;Genes;Genetic Polymorphism;Glycolysis;Goals;Grant;Hepatic;Hepatocyte;High Fat Diet;Histopathologic Grade;Homeostasis;Human;human disease;Immune;Immunologics;Inflammation;Inflammatory;Insulin Resistance;interest;Kinetics;Knockout Mice;Lipodystrophy;Liver;liver biopsy;liver inflammation;liver metabolism;Mediating;Metabolic;Metabolic Diseases;Metabolism;Mitochondria;mitochondrial metabolism;Modeling;Molecular;mouse model;multicatalytic endopeptidase complex;Mus;Mutation;Nature;Nutritional status;Obesity;old mice;Oxidative Phosphorylation;Pathologic;Pathology;Pathway interactions;Patients;Peptides;Play;Population;preference;protein degradation;Proteins;Proteomics;Rare Diseases;Rattus;recruit;Regulation;Respiration;Role;screening;Signal Transduction;Systems Biology;therapeutic target;Tissues;Ubiquitination;Work

PROJECT_TITLE: The 11S-associated immunoproteasome in mitochondrial function and metabolic disorders

STUDY_SECTION: POMD

STUDY_SECTION_NAME: Pathophysiology of Obesity and Metabolic Disease Study Section[POMD]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Brain Disorders;Drug Abuse (NIDA only);Nanotechnology;Neurosciences;Opioid Misuse and Addiction;Opioids;Prevention;Substance Misuse

ORG_CITY: La Jolla

ORG_NAME: NEURANO BIOSCIENCE

PHR: PROJECT NARRATIVE Despite concerted efforts to address the opioid epidemic in the United States, the opioid overdose death rates are still high, and the opioid use is still on the rise. This unfortunate reality demands the development of novel therapeutic approaches, preferably with non-opioid mechanisms of action. NMDAR-mediated pathways are implicated in several processes underlying the development and maintenance of addiction, and therefore NMDAR antagonists may be able to prevent the formation of compulsive drug-taking behaviors, reduce physical opioid withdrawal symptoms, and/or prevent relapse. In an effort to contribute to the fight against OUD, we developed a novel NMDAR-targeting nanotherapeutic that is expected to exhibit enhanced therapeutic efficacy and improved safety profile because it can only block NMDARs outside the synapses. In the proposed project, we will evaluate the safety and abuse potential of our nanotherapeutic, and explore the entire spectrum of its potential therapeutic effects in animal models of opioid addiction.

PI_NAMEs: MOLOKANOVA, ELENA  (contact)

PROGRAM_OFFICER_NAME: SABIRZHANOV, BORIS YEVGENYEVICH

PROJECT_TERMS: abuse liability;Acute;addiction;Address;Affect;analytical method;Animal Model;Animals;antagonist;Anxiety;Awareness;Behavior;behavior test;behavioral study;Biological Markers;Biological Sciences;Blinded;Brain;Brain-Derived Neurotrophic Factor;Buprenorphine;Chemistry;Clinical;Control Animal;Control Groups;cytokine;Data;Death Rate;design;Development;Dimensions;dosage;Dose;Drug Targeting;economic impact;effectiveness evaluation;efficacy study;Endotoxins;Engineering;Ensure;Enzyme-Linked Immunosorbent Assay;Epidemic;Evaluation;Exhibits;experience;Extinction;extracellular;FDA approved;fighting;flexibility;Formulation;Future;Glutamates;Goals;Guidelines;Human;improved;in vivo;Inflammatory;Infusion procedures;Intranasal Administration;Link;Maintenance;manufacturability;manufacture;Mediating;Memantine;Memory;Methods;Microglia;Morphine;Morphine Dependence;mortality risk;N-Methyl-D-Aspartate Receptors;Naloxone;nanoGold;nanoparticle;nanotherapeutic;neuroinflammation;neuroprotection;NMDA receptor antagonist;non-opioid analgesic;novel;novel therapeutic intervention;novel therapeutics;Opiate Addiction;Opioid;opioid epidemic;opioid mortality;Opioid Receptor;opioid use;opioid use disorder;opioid withdrawal;Outcome;Pathway interactions;Patients;Pharmaceutical Preparations;pharmacologic;phase 1 study;phase 2 study;Placebos;Politics;preclinical efficacy;preclinical study;prevent;Prevention;Probability;Process;Property;Protocols documentation;Quantitative Reverse Transcriptase PCR;rational design;receptor;Relapse;relapse prevention;relapse risk;Reporting;Reproducibility;Research;Research Contracts;Rewards;Risk Reduction;Route;Safety;Saline;scale up;Scientist;Self Administration;Severities;side effect;social;socioeconomics;standard of care;success;Synapses;Synaptic Cleft;synaptic inhibition;System;Testing;Therapeutic;Therapeutic Effect;therapeutic evaluation;Time;Treatment Efficacy;treatment group;United States;United States National Institutes of Health;Validation;Western Blotting;Withdrawal;Withdrawal Symptom;zeta potential

PROJECT_TITLE: Evaluation of the therapeutic potential of exclusive antagonists of extrasynaptic NMDA receptors for the treatment of opioid use disorder


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Clinical Research;Contraception/Reproduction;Endometriosis;Pain Research;Patient Safety;Prevention;Women's Health Research

ORG_CITY: PHILADELPHIA

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE (2-3 sentences maximum) This project is relevant to public health because prediction of endometriosis risk can enhance the quality of life for more than 200,000 women per year in the United States and the mediating risk models benefit not only endometriosis but also screening individuals for preventive measures to reduce illness due to associated morbidities such as depression, anxiety, ovarian cancer, and myocardial infraction. This research aligns with NICHD's mission to improve quality of life for all women by predicting risk of endometriosis early and identifying preventive measures for long- term effects of endometriosis.

PI_NAMEs: VERMA, SHEFALI SETIA (contact)

PROGRAM_OFFICER_NAME: TINGEN, CANDACE M

PROJECT_TERMS: abstracting;Address;Affect;Age;Anxiety;biobank;Case Study;Cataloging;Catalogs;Chronic;Chronic Disease;chronic pelvic pain;Chronology;Clinical;clinical practice;clinical predictors;clinical risk;comorbidity;Computing Methodologies;Data;Development;Diagnosis;Diagnostic;Disease;disease heterogeneity;disorder risk;Distant;Dysmenorrhea;Early Diagnosis;early screening;Electronic Health Record;electronic health record system;endometriosis;Environmental Risk Factor;epigenomics;Event;Female Genital Diseases;Future;Genetic;genetic variant;genome wide association study;genomic biomarker;Goals;Gynecologic;Health;heart disease risk;Heterogeneity;high risk;High Risk Woman;Hormonal;improved;Incidence;Individual;Infertility;Inflammation;inflammatory marker;innovation;Knowledge;Life;Life Cycle Stages;Life Style;lifetime risk;Link;Long-Term Effects;long-term sequelae;Machine Learning;Malignant Female Reproductive System Neoplasm;Malignant neoplasm of ovary;Maps;Mediating;Mediator;Medicine;Mental Depression;Methodology;Methods;Mission;Modeling;modifiable risk;Morbidity - disease rate;multimodality;Myocardial;National Institute of Child Health and Human Development;non-genetic;novel;Organ;Outcome;Patient risk;Patient-Focused Outcomes;Patients;Pelvis;personalized medicine;Phenotype;Play;polygenic risk score;Population;Prevalence;prevent;Prevention;Prevention strategy;Preventive measure;Public Health;Quality of life;Relative Risks;Reporting;Reproduction;reproductive;Research;Risk;Risk Assessment;Risk Estimate;Risk Factors;risk prediction;risk prediction model;risk sharing;Role;screening;Screening procedure;Sum;symptomatology;Symptoms;Systemic disease;Testing;timeline;tool;Translating;United States;Validation;Variant;Woman;women's diagnosis;Work

PROJECT_TITLE: Integrative risk modeling for early prediction of endometriosis and its long-term health outcomes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-A(90)S]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Rare Diseases;Tuberculosis

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

PHR: Project Narrative Compromised cell migration leads to developmental and immune disorders. This project will investigate cytoskeletal changes that underlie cell migration, focusing on novel roles for a set of proteins that regulate this process.

PI_NAMEs: SWEENEY, MOLLIE  (contact)

PROGRAM_OFFICER_NAME: YABE, IDALIA MONTANO

PROJECT_TERMS: Actins;Animals;Bacteria;Behavior;Biology;Bulla;cell motility;Cell Physiology;Cell Shape;Cells;Cellular biology;Clinical;Complex;CRISPR/Cas technology;Cues;Cytoskeleton;Data;developmental disease;Disease;F-Actin;Filopodia;Genetic;genetic manipulation;Genus Mycobacterium;Goals;Granuloma;high resolution imaging;Homeostasis;Human;human disease;human pathogen;Immune System Diseases;Immunity;in vivo;Infection;Infection Control;insight;Integration Host Factors;Invaded;Investigation;Knock-out;Knowledge;Length;Macrophage;Macrophage Cell Biology;Mediating;member;Membrane;Microscopy;migration;Modeling;Morphology;Motility;mouse model;Mus;Mutant Strains Mice;mycobacterial;Mycobacterium Infections;Mycobacterium marinum;Mycobacterium tuberculosis;Natural Immunity;novel;Optics;Outcome;pathogen;Pathogenesis;Pathway interactions;Pattern;Phagocytes;Pharmacological Treatment;Phenotype;Play;Process;protein complex;Reporter;Resolution;response;Role;Set protein;Shapes;Site;Sorting;System;Testing;Therapeutic;Time;tool;trafficking;Translating;Tuberculosis;Work;wound;Zebrafish

PROJECT_TITLE: Roles for the WASH complex in macrophage migration and function

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-D(21)L]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Congenital Structural Anomalies;Genetics;Neurosciences;Pediatric;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: ANN ARBOR

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Public Health Relevance Statement The prevalence of neurodevelopmental brain diseases constitutes a serious health problem in our society. Despite their prevalence and dire consequences, neurodevelopmental brain diseases remain challenging to study. This proposed research will develop a promising stem cell-based human brain development model and will further utilize this model to study genetic mechanisms underlying dysregulated brain development, in conjunction with mutant mouse models.

PI_NAMEs: FU, JIANPING  (contact);REINER, ORLY

PROGRAM_OFFICER_NAME: LAVAUTE, TIMOTHY M

PROJECT_TERMS: 3-Dimensional;Address;Animal Model;Benchmarking;Biological Models;Brain;brain abnormalities;Brain Diseases;Brain region;Cell division;Cells;Central Nervous System;comparative;Data;Development;Developmental Process;Disease;disease model;disease phenotype;DNA Sequence Alteration;Dorsal;Elements;Embryo;Etiology;Exhibits;Genes;Genetic;Genetic study;genome sequencing;Geometry;Goals;Growth;Health;hindbrain;Human;human model;human pluripotent stem cell;in vitro Model;in vivo;Individual;innovation;Knock-out;Knockout Mice;Measurement;Mediating;Microcephaly;Microfluidic Microchips;Microfluidics;Midbrain structure;model development;Modeling;morphogens;Motility;mouse model;Mus;mutant;mutant mouse model;Mutation;nerve stem cell;neural network;neural patterning;Neural tube;Neural Tube Development;neurodevelopment;novel;Nuclear;Organoids;Pathology;Pattern;personalized medicine;Positioning Attribute;Pregnancy;Prevalence;Process;Property;Prosencephalon;Proteins;Protocols documentation;public health relevance;Reproducibility;Research;Role;self organization;single-cell RNA sequencing;Societies;spatiotemporal;Spinal Cord;stem cells;Structure;Technology;Tissues;tool;transcriptome;Tubular formation

PROJECT_TITLE: Modeling NDE1 function in dysregulated brain development using a microfluidic CNS model

STUDY_SECTION: BNVT

STUDY_SECTION_NAME: Bioengineering of Neuroscience, Vision and Low Vision Technologies Study Section[BNVT]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Neurodegenerative;Neurosciences

PHR: For years the field has struggled with the question of whether TDP-43 protein deposited in the brains of the elderly with limbic-predominant age-related TDP-43 encephalopathy (LATE) is biologically different from TDP- 43 deposited in FTLD-TDP brains. We propose to isolate and characterize TDP-43 species or strains from LATE-NC and FTLD-TDP brains to determine whether specific structural properties and/or biological activities are associated with these differing TDP-43 proteinopathies, which could lay the foundation to engineer small molecules that bind to specific TDP-43 strains for use as biomarkers or ligands for imaging studies in humans. Disease-specific diagnoses are needed for clinical trials to identify appropriate patients and perhaps therapeutic candidates that are specific for different TDP-43 proteinopathies.

PI_NAMEs: PORTA ANTOLINEZ, SILVIA  (contact)

PROGRAM_OFFICER_NAME: LI, TONG

PROJECT_TERMS: Affect;age related;Age Years;Alzheimer's Disease;Amygdaloid structure;Amyotrophic Lateral Sclerosis;Area;Autopsy;Binding;Biochemical;Biological;Biological Markers;Brain;Brain Diseases;Cells;Characteristics;Clinical;Clinical Trials;conformer;Dementia;Deposition;Diagnosis;Disease;DNA-Binding Proteins;Elderly;Encephalopathies;Engineering;entorhinal cortex;Epidemiology;Foundations;Freezing;frontal lobe;Frontotemporal Lobar Degenerations;Gene Expression Profile;Genetic;Genetic Predisposition to Disease;Heterogeneity;hippocampal atrophy;Hippocampus;Human;Imaging ligands;imaging study;immunoreactivity;Impaired cognition;In Vitro;in vitro activity;in vivo;Individual;insight;limbic-predominant age-related TDP-43 encephalopathy;Maps;Memory Loss;Molecular;Molecular Conformation;monomer;Morphology;Neurofibrillary Tangles;neuroimaging;Neurons;neuropathology;Pathogenicity;Pathologic;Pathology;Patients;Pattern;Persons;Phosphorylation;Property;protein TDP-43;Recombinants;Reporting;Research Proposals;response;Retrospective Studies;Sampling;Signal Pathway;small molecule;Stereotyping;Structure;Symptoms;Syndrome;tau Proteins;TDP-43 aggregation;Testing;therapeutic candidate;transcriptomics;Ubiquitin

PROJECT_TITLE: Biochemical and molecular heterogeneity of human TDP-43 proteinopathies in age-related dementias

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Rural Health;Social Determinants of Health

ORG_CITY: RICHMOND

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: This K12 training program from partner institutions at the Wright Regional Center for Clinical and Translational Research will train scholars to translate research observations to clinical application in our unique communities. Our program will continue its commitment to providing early career faculty/late-stage postdoctoral fellows with a comprehensive “blueprint” for transitioning to research independence. We will further leverage our bidirectional partnerships with local institutions (EVMS, ODU, and VSU), further synergize with internal programs (UM1, T32 and RC2) and Center on Health Disparities pipeline training grants to promote the development of a diverse research workforce (K12, T32, R25), and to further build a community of scholarship while fostering the development of a pipeline beyond our K12 scholars.

PI_NAMEs: NANASINKAM, SERGE PATRICK (contact);NEIGH, GRETCHEN N

PROGRAM_OFFICER_NAME: BOUGH, KRISTOPHER J

PROJECT_TERMS: Award;career;career development;Characteristics;Clinical;clinical application;clinical center;Clinical Sciences;Communities;community based research;community engaged research;COVID-19 pandemic;demographics;Development;Discipline;early-career faculty;Endowment;Environment;experience;Exposure to;Face;Faculty;Goals;Health;health disparity;health inequalities;Health Promotion;human disease;improved;Informatics;innovation;Institution;Life Cycle Stages;medical schools;Mentored Clinical Scientist Development Program;Mentorship;Nature;North Carolina;Observational Study;Patients;Physicians;Positioning Attribute;Postdoctoral Fellow;pre-clinical;programs;Public Health;recruit;Reporting;Research;Research Training;Resources;rural underserved;Scientist;Time;Training;Training and Infrastructure;Training Programs;Translating;translational pipeline;Translational Research;translational scientist;underserved community;United States National Institutes of Health;Universities;urban underserved;Virginia;virtual

PROJECT_TITLE: CTSA K12 Program at Virginia Commonwealth University


NIH_SPENDING_CATS: Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: CHAPEL HILL

ORG_DEPT: BIOLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: Understanding the signaling pathways and networks that control development and stem cell production in plants will enable us to elucidate the common regulatory principals which govern stem cell biology and development across all species, including humans. This knowledge could help in efforts to engineer synthetic signaling circuits to probe human disease pathways and develop new clinical applications. Additionally, as projected population increases impact future food challenges, the ability to modify these pathways could help improve yield and nutritional qualities of critical crop species.

PI_NAMEs: NIMCHUK, ZACHARY LUKE (contact)

PROGRAM_OFFICER_NAME: SALAZAR, DESIREE LYNN

PROJECT_TERMS: Animals;Arabidopsis;Biology;cell behavior;Cell Communication;Cell division;Cell Maintenance;Cells;clinical application;Collaborations;Detection;Development;Developmental Process;Disease;Disease Pathway;Dissection;Engineering;food challenge;Future;Genetic Transcription;Goals;Hormones;Human;Human Development;human disease;Immune response;Immunity;improved;insight;Knowledge;Modeling;Monitor;novel;Nutritional;pathogen;Pathway interactions;Peptide Receptor;Peptide Signal Sequences;Peptides;Phosphotransferases;plant growth/development;Plant Model;Plants;Population;Postdoctoral Fellow;Production;programs;Public Health;receptor;Receptor Signaling;Regulation;Regulator Genes;Scientist;Series;Shapes;Signal Pathway;Signal Transduction;stem cell biology;stem cell niche;stem cell proliferation;stem cells;System;Temperature;Therapeutic;Tissues;Training;undergraduate student;Whole Organism;Work;working group

PROJECT_TITLE: Receptor kinase signal integration in stem cell maintenance and development.

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


NIH_SPENDING_CATS: Behavioral and Social Science;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Complementary and Integrative Health;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy;Physical Rehabilitation;Precision Medicine;Rehabilitation

ORG_CITY: CHARLESTOWN

ORG_NAME: SPAULDING REHABILITATION HOSPITAL

ORG_STATE: MA

PHR: Project Narrative Chronic Phantom Limb Pain (PLP) is recognized as very difficult to treat as it is often resistant to classical pharmacological and surgical treatment approaches. Our previous R01 and research studies have shown significant and robust results to support a combined therapy with tDCS and somatosensory training. In this study we propose to test the real-world effects of home-based tDCS combined with a somatosensory training in a pragmatic trial design and a machine-learning analysis to find the best predictors of response.

PI_NAMEs: FREGNI, FELIPE  (contact)

PROGRAM_OFFICER_NAME: BONNER, JOSEPH FRANCIS

PROJECT_TERMS: Address;Affect;Anodes;Anterior;Area;Behavior Therapy;Behavioral;Biological Markers;Brain;Characteristics;Chronic;chronic neuropathic pain;chronic pain;Clinical;clinical predictors;cognitive training;Combined Modality Therapy;comparison control;Conduct Clinical Trials;Control Groups;cost;Data;design;Devices;Disease;Effectiveness;effectiveness evaluation;effectiveness testing;efficacy testing;Esthesia;evidence base;experience;Force of Gravity;functional restoration;Goals;gray matter;Hand;Health Professional;heart rate variability;Home;improved;indexing;Individual;innovation;Intervention;Investigation;Knowledge;Life;Machine Learning;machine learning algorithm;machine learning method;Meta-Analysis;Modernization;Motor;Motor Cortex;Movement;neural;neural circuit;neuroimaging;neurological rehabilitation;neuronal circuitry;neurophysiology;neuroregulation;noninvasive brain stimulation;novel;Occupational Therapy;Operative Surgical Procedures;Pain;Pain management;pain patient;pain reduction;pain relief;painful neuropathy;Paper;Patients;Phantom Limb;Phantom Limb Pain;pharmacologic;Pharmacological Treatment;Phenotype;Physical therapy;portability;pragmatic trial;predicting response;Prediction of Response to Therapy;Probability;Protocols documentation;Publishing;Randomized;Rehabilitation therapy;remote assessment;remote therapy;Research;research study;residual limb;Resistance;response;response biomarker;somatosensory;spinal cord injury pain;statistical and machine learning;Surrogate Markers;Syndrome;Techniques;Technology;Testing;Therapeutic;Training;transcranial direct current stimulation;treatment as usual;treatment response;treatment strategy;trial design;Underrepresented Populations;Validation;Visit

PROJECT_TITLE: Pragmatic Trial of Remote tDCS and Somatosensory Training for Phantom Limb Pain with Machine Learning to Predict Treatment Response

STUDY_SECTION: NPI

STUDY_SECTION_NAME: Neurobiology of Pain and Itch Study Section [NPI]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

PHR: O-GlcNAcylation is the attachment of a single O-linked β-N-acetyl-D-glucosamine moiety to serine/threonine residues of nuclear, mitochondrial, and cytoplasmic proteins; as such, this modification regulates numerous cellular process such transcription, translation, cell cycle, and signaling. Importantly, O-GlcNAc is a critical regulator of mitochondrial function and disruption in the normal homeostatic levels of O-GlcNAc impairs respiration. This proposal will develop a new understanding of how O-GlcNAc regulates mitochondrial respiration and anti-oxidant response in the context of Alzheimer’s disease.

PI_NAMEs: SLAWSON, CHAD ERIC (contact)

PROGRAM_OFFICER_NAME: YANG, AUSTIN JYAN-YU

PROJECT_TERMS: Affect;Aftercare;age-related disease;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer’s disease biomarker;American;Amino Acids;Amyloid;animal tissue;Antioxidants;biological adaptation to stress;Categories;Cell Cycle;cell injury;Cell Line;Cell Physiology;Cells;Chronic;Citric Acid Cycle;Clinical Pathways;Cues;Cytoplasmic Protein;Data;Development;Diagnostic;diagnostic biomarker;Disease;Disease Progression;Electron Transport;Environment;environmental change;Enzymes;Etiology;extracellular;Gene Expression;Genes;Genetic Transcription;Glucosamine;Homeostasis;Hormones;Impairment;Inflammation;inhibitor;Intervention;knock-down;Link;Mass Spectrum Analysis;Measures;Metabolic;Metabolic Diseases;Metabolic dysfunction;Methods;Mitochondria;mitochondrial dysfunction;Mitochondrial Proteins;Modification;Morphology;mouse model;Mus;neurofibrillary tangle formation;neuronal metabolism;novel;novel therapeutics;nuclear factor-erythroid 2;Nuclear Proteins;Nutrient;O-GlcNAc transferase;overexpression;Oxidative Stress;peptide O-linked N-acetylglucosamine-beta-N-acetylglucosaminidase;Physiology;Post-Translational Protein Processing;Prevention;Production;protein expression;Proteins;Proteome;Proteomics;Public Health;Publishing;Reactive Oxygen Species;Regulation;Research;Respiration;response;Role;Sampling;Serine;Signal Transduction;Site;spatial memory;Symptoms;tau Proteins;Testing;Threonine;Tissues;transcription factor;Transcriptional Regulation;transcriptome;Translations

PROJECT_TITLE: O-GLCNAC HOMEOSTASIS REGULATES MITOCHONDRIAL FUNCTION IN ALZHEIMER'S DISEASE

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD]


ORG_CITY: DAVIS

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: TRAINING PROGRAM IN PHARMACOLOGY Project Narrative (Public Health Statement) The Training Program in Pharmacology at UC Davis provides unique training in drug discovery and development to educate future biomedical researchers, who will be involved in the creation of novel therapeutic treatments of diseases in various areas. It builds on the existing strengths in the interdisciplinary collaborative research and training environment at UC Davis, where training program faculty have developed and clinically test new drugs and other therapeutics and diagnostics. It will train predoctoral PhD students in pharmacology and foster interdisciplinary training and research collaborations in drug discovery and development for graduate students in Pharmacology, Neuroscience, Physiology, and Biomedical Engineering graduate programs. A combination of formal and informal research training experiences will provide trainees with an understanding of how basic and clinical sciences are integrated to translate therapeutic target discovery to drug development, screening, mechanistic preclinical and clinical studies.

PI_NAMEs: BERS, DONALD M;HELL, JOHANNES W (contact)

PROGRAM_OFFICER_NAME: BLATCH, SYDELLA ANNE

PROJECT_TERMS: Pharmacology;Training Programs

PROJECT_TITLE: Training Program in Pharmacology

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - B[TWD-B]


ADMINISTERING_IC: LM

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Data Science;Networking and Information Technology R&D (NITRD)

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Clinical data in electronic health records is annotated with a freely accessible coding system (LOINC® codes from Regenstrief). While helpful for interoperability, these codes do not optimally support data science and reasoning. We will overlay reasoning relationships onto LOINC codes, and make this a new, open resource for data science.

PI_NAMEs: CHUTE, CHRISTOPHER G (contact)

PROGRAM_OFFICER_NAME: REDDY, GOUTHAM

PROJECT_TERMS: Adopted;Biological;biomedical data science;biomedical ontology;Biomedical Research;Blood Glucose;Catalogs;Chemicals;Classification;Clinical;Clinical Data;clinical practice;Code;Communities;computational reasoning;Data;Data Collection;Data Science;data science resource;Data Set;Databases;Diagnostic;Discrimination;Education;Electronic Health Record;Elements;Engineering;Fast Healthcare Interoperability Resources;Feedback;Genomics;Goals;interest;interoperability;knowledgebase;Laboratories;Libraries;Link;Logic;Logical Observation Identifiers Names and Codes;Maps;Metabolic;Modeling;Modernization;Ontology;ontology development;open data;Play;Questionnaires;Reference Standards;Report (document);Research;Resources;Role;Services;Source;Specific qualifier value;Structure;System;Terminology;Trust;Web Ontology Language;Work

PROJECT_TITLE: Computational LOINC to Support Biomedical Research at Scale


NIH_SPENDING_CATS: Genetics;Neurosciences

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: NARRATIVE Our Projects are focusing on (1) the identification of cellular and molecular effectors regulating the development of cortical circuits and (2) the discovery of human-specific genes and their functions during cortical circuit development and function. These projects will shed unique light onto what makes the human brain unique and both projects will improve significantly our understanding of cellular and molecular processes affected in socially devastating diseases such as neurodevelopmental disorders or neurodegenerative diseases.

PI_NAMEs: POLLEUX, FRANCK  (contact)

PROGRAM_OFFICER_NAME: RIDDLE, ROBERT D

PROJECT_TITLE: Development, Maintenance, and Human-Specific Evolution of Cortical Circuits


NIH_SPENDING_CATS: Behavioral and Social Science;Bipolar Disorder;Brain Disorders;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Hypertension;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Patient Safety;Prevention;Primary Health Care;Serious Mental Illness;Telehealth

ORG_CITY: CLEVELAND

ORG_DEPT: PSYCHIATRY

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE  Using a prospective 2-stage randomized controlled trial design,the proposed project will evaluate the efficacy of a personalized and automatized m-Health intervention targeting both intentional and non-intentional non- adherence, iTAB-CV + Self-Monitoring, compared to Self-Monitoring alone to improve medication adherence and lower systolic blood pressure in individuals with bipolar disorder (BD) and hypertension. Given the serious negative consequences of uncontrolled hypertension, including early mortality, an intervention that successfully improves adherence to antihypertensive medications while simultaneously addressing psychiatric medication adherence and which can be administered via text messaging would be of substantial public health benefit. This project will explore the mechanism of action of the intervention and its results will form the basis for future implementation-effectiveness trials.

PI_NAMEs: LEVIN, JENNIFER BETH (contact);SAJATOVIC, MARTHA X

PROGRAM_OFFICER_NAME: CAMPO, REBECCA A

PROJECT_TERMS: academic standard;Accounting;Acute;Address;Adherence;Anti-Hypertensive Agents;Attitude;automated text message;Behavior;Bipolar Disorder;Blood Pressure;blood pressure reduction;Cardiovascular Diseases;cardiovascular health;Cardiovascular system;Caring;Cellular Phone;Cessation of life;Chronic;Clinical;comorbidity;Death Rate;Dose;effectiveness/implementation trial;efficacy evaluation;efficacy testing;Electronics;Event;Family member;Frequencies;Functional impairment;Future;future implementation;General Population;Habits;Health;Health Benefit;Health Promotion;high risk population;Home Blood Pressure Monitoring;Hypertension;hypertensive;Impaired cognition;implementation efforts;improved;Individual;Intervention;intervention delivery;Length;Measures;Mediation;Mediator;Medical;medical complication;medication compliance;medication nonadherence;member;Memory impairment;Mental Depression;Mental disorders;Mental Health;mHealth;Modeling;Modification;Monitor;mood symptom;Moods;mortality;Motivation;Outcome;Participant;Patient Care;Patient Compliance;patient oriented;Patient Self-Report;patient subsets;Patients;Persons;Pharmaceutical Preparations;physical conditioning;pill;pilot trial;Population;post intervention;premature;Prevention;Primary Care;Primary Care Physician;primary outcome;prospective;prospective memory;Provider;psychiatric symptom;psychoeducation;Public Health;Questionnaires;Randomized;Randomized, Controlled Trials;Regimen;response;Risk;scale up;secondary outcome;Self Efficacy;social influence;Tablets;Technology;Testing;Text;Text Messaging;trial comparing;trial design;Writing

PROJECT_TITLE: Using mHealth to improve adherence and reduce blood pressure in individuals with hypertension and bipolar disorder

STUDY_SECTION: CMPC

STUDY_SECTION_NAME: Clinical Management of Patients in Community-based Settings Study Section[CMPC]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Clinical Research;Genetics;Human Genome;Rare Diseases

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: PUBLIC HEALTH RELEVANCE STATEMENT Discovering the genetic underpinnings of Mendelian disease to enable patient diagnosis and guide treatment is greatly facilitated by diverse genomics assays and computational methods. To enable the next stages in Mendelian disease diagnoses, our Mendelian Genomics Research Consortium Center will study in high detail 500 individuals and their families where current clinical genomics technologies have not achieved diagnoses. Our Center will provide essential insights into emerging functional genomics and targeted approaches for gene and variant discovery.

PI_NAMEs: BERNSTEIN, JONATHAN ADAM;MONTGOMERY, STEPHEN  (contact);WHEELER, MATTHEW THOMAS

PROGRAM_OFFICER_NAME: CHADWICK, LISA

PROJECT_TERMS: Acceleration;ATAC-seq;biobank;Biological Assay;causal variant;Cell Line;Cells;Clinical;clinical care;clinical practice;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;computational pipelines;Computing Methodologies;Coupled;CRISPR interference;CRISPR screen;Data;data integration;Data Set;data sharing;Development;Diagnosis;Diagnostic;Disease;disease diagnosis;DNA sequencing;Engineering;Enrollment;epigenomics;Ethnic Origin;Evaluation;exome;exome sequencing;Family;Family member;Family Study;Fostering;frontier;functional genomics;gene discovery;Gene Expression;Genes;Genetic;genetic disorder diagnosis;genetic signature;genetic variant;genome sequencing;Genomic approach;genomic data;Genomics;high standard;improved;In Vitro;in vivo;Individual;induced pluripotent stem cell;innovation;insight;Knowledge;Laboratories;Leadership;lipidomics;Literature;Mendelian disorder;metabolomics;Methods;mouse model;Multiomic Data;multiple omics;novel;novel strategies;Participant;Patients;Phase;Phenotype;population based;Process;public health relevance;Rare Diseases;rare genetic disorder;rare variant;recruit;Reporter;Reporter Genes;Reproducibility;Research;Research Personnel;Research Support;Resources;Risk;sex;Site;statistical learning;synergism;Techniques;Technology;Testing;Tissues;transcriptome sequencing;translational genomics;Triage;Validation;Variant;whole genome;Work

PROJECT_TITLE: Stanford Mendelian Genomics Research Center


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Data Science;Emergency Care;Emerging Infectious Diseases;Health Services;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Otitis Media;Patient Safety;Pediatric;Primary Health Care

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: The proposed research is relevant to public health because we are generating new methods aimed at improving diagnostic quality and reducing interobserver variability, which will ultimately enable more accurate diagnosis and personalized therapeutic approaches for ear abnormalities. Thus, the proposed research is relevant to NIH’s mission pertaining to the application of novel strategies that may improve human health and NIDCD’s mission of improving the diagnosis and treatment of ear diseases, particularly otitis media.

PI_NAMEs: GURCAN, METIN NAFI;MOBERLY, AARON C (contact)

PROGRAM_OFFICER_NAME: WATSON, BRACIE

PROJECT_TERMS: Academy;accurate diagnosis;Acute;Adverse event;Algorithms;American;Antibiotics;Awareness;Bacterial Antibiotic Resistance;Child;Childhood;Clinical;Clinical Data;Clinical Decision Support Systems;clinical examination;Clip;cognitive development;Computer Assisted;Computer software;Computer-Assisted Diagnosis;Computer-Assisted Image Analysis;Data;Data Sources;Decision Support Systems;deep learning;Devices;Diagnosis;Diagnostic;diagnostic accuracy;digital;Ear;Ear Diseases;ear infection;effectiveness evaluation;effusion;Emergency Medicine;emergency settings;experience;Financial Hardship;Foundations;Goals;Guidelines;Health;Health Care Costs;hearing impairment;Human;Image;Image Analysis;improved;Individual;Insufflation;Interobserver Variability;Label;Language Development;large datasets;Machine Learning;machine learning algorithm;Medical;Methods;middle ear fluid;Mission;Movement;National Institute on Deafness and Other Communication Disorders;Nature;Nose;novel;novel strategies;Nurse Practitioners;Operative Surgical Procedures;Oral;Otitis Media;Otitis Media with Effusion;Otoscopes;Otoscopy;overtreatment;Pathologist;Pathology;Pediatrics;Performance;personalized therapeutic;Pharmaceutical Preparations;Pharyngeal structure;Physician Assistants;Physicians;Primary Care;primary care clinician;Primary Care Physician;prototype;Provider;Public Health;radiologist;Reader;Recommendation;recurrent infection;Research;Side;software development;Support System;System;Techniques;Technology;Testing;tool;Training;Tube;Tympanic membrane;Tympanometry;United States National Institutes of Health;Visual;Work

PROJECT_TITLE: Computer-assisted diagnosis of ear pathologies by combining digital otoscopy with complementary data using machine learning

STUDY_SECTION: CIDH

STUDY_SECTION_NAME: Clinical Informatics and Digital Health Study Section[CIDH]