NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Congenital Heart Disease;Genetics;Heart Disease;Neurosciences;Orphan Drug;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Project Narrative: This project will investigate the molecular mechanism underlying a genetic syndromic disorder called Timothy syndrome showing severe and lethal cardiac arrhythmia. Our team will take advantage of our new technology and expertise to develop new drug candidates on experimental platforms using cardiac muscle cells derived from human patients as well as small animal models. This translational approach will open new avenue to identify novel therapeutics for human genetic cardiac arrhythmias.

PI_NAMEs: YAZAWA, MASAYUKI  (contact)

PROGRAM_OFFICER_NAME: BALIJEPALLI, RAVI C

PROJECT_TERMS: absorption;Action Potentials;Address;Agonist;Animal Model;antagonist;Arrhythmia;Biological Assay;Birth;Blood - brain barrier anatomy;Brain;Calcium Channel;cancer clinical trial;Cardiac;Cardiac Myocytes;cardiac tissue engineering;CDC2 gene;Cell model;Central Nervous System;Chemicals;Client;Clinical;Coughing;Coupling;Cyclin-Dependent Kinase 5;design;Dextromethorphan;Disease;disease model;drug candidate;drug development;Electrocardiogram;Electrophysiology (science);Excretory function;experience;experimental study;FDA approved;Fluvoxamine;Functional disorder;gain of function mutation;Genetic;genetic approach;Genetic Diseases;Genetic Models;Goals;Heart;heart function;Hepatotoxicity;Human;Human Engineering;Human Genetics;human induced pluripotent stem cells;In Vitro;in vivo;induced pluripotent stem cell;Infant;inhibitor;insight;knock-down;L-type calcium channel alpha(1C);Lead;life span;Long QT Syndrome;Metabolism;Molecular;Molecular Chaperones;mouse model;Mus;Muscle Cells;N-Methyl-D-Aspartate Receptors;Names;Neurons;new technology;novel;novel therapeutics;overexpression;Patients;Permeability;Pharmaceutical Chemistry;Pharmaceutical Preparations;Pharmacologic Substance;Phenotype;Physiological;Play;Potassium;Proteins;Proteomics;Receptor Activation;receptor binding;Reporting;Rodent Model;Role;Romano-Ward Syndrome;Science;Selective Serotonin Reuptake Inhibitor;side effect;sigma-1 receptor;small hairpin RNA;small molecule;Specificity;stem cell model;Testing;Therapeutic;therapeutic target;Timothy syndrome;translational applications;translational approach;translational study;Vision;Work

PROJECT_TITLE: Novel Therapeutics for Timothy Syndrome and Related Cardiac Channelopathy

STUDY_SECTION: TDPS

STUDY_SECTION_NAME: Therapeutic Development and Preclinical Studies Study Section[TDPS]


ADMINISTERING_IC: ES

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Prevention

ORG_CITY: CAMBRIDGE

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

ORG_STATE: MA

PHR: PROJECT NARRATIVE – RESEARCH EXPERIENCE AND TRAINING COORDINATION CORE The Research Experience and Training Coordination Core (RETCC) recruits the best and the brightest trainees, provides cross disciplinary research training, and propels all of the activities of the MIT Superfund Research Program that, together, enable protection of people from the effects of hazardous chemicals. The RETCC coordinates with the Administrative Core and the Community Engagement Core to ensure that trainees have exciting research translation opportunities (and regular contact with community members and organizations at the local, state, national, and tribal levels), as well as opportunities to listen to, learn from, and collaborate with community members and tribes. By fostering teamwork and nurturing trainees with a supportive environment, strong mentorship, and formal and informal enrichment activities, the MIT SRP trainees will continue to promote the public health impact of the MIT SRP.

PI_NAMEs: ESSIGMANN, JOHN M (contact)

PROJECT_TERMS: Animal Model;Award;Awareness;Biomedical Research;Carcinogens;career;career development;Chemicals;Chloramines;Communities;community collaboration;community engagement;Data;Data Analyses;data management;Democracy;Development;Devices;Dimethylnitrosamine;diversity and inclusion;drinking water;Educational workshop;Engineering;Environmental Engineering technology;Environmental Health;Environmental Science;Ethics;Evaluation;experience;Exposure to;Family;Fellowship;Filtration;Fostering;Foundations;Gender;Goals;graduate student;Hazardous Chemicals;Health;Human;implicit bias;Influentials;innovation;Interdisciplinary Study;Investments;Laboratories;Learning;Mainstreaming;Measures;meetings;member;Mentors;Mentorship;Methods;Mission;Municipalities;Mutagens;N-nitrosodimethylamine;next generation;Nitrosamines;Nitroso Compounds;Passamaquoddy;Personal Satisfaction;Persons;Policies;Postdoctoral Fellow;Problem Solving;programs;Public Health;Race;recruit;Research;Research Personnel;Research Project Grants;Research Support;Research Training;responsible research conduct;Risk;Rotation;Science;sensor;Social Responsibility;STEM career;Students;Superfund;superfund chemical;superfund site;supportive environment;System;Time;Training;training opportunity;translational potential;Translational Research;Translations;Tribes;undergraduate research;undergraduate research experience;underrepresented minority student;Water;water treatment;Work

PROJECT_TITLE: Core D: Research Experience and Training Coordination Core


ADMINISTERING_IC: AI

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Infectious Diseases;Rare Diseases

ORG_CITY: BALTIMORE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PI_NAMEs: RUIZ, FERNANDO  (contact)

PROJECT_TERMS: Age;Award;Binding;Biological Assay;CD14 gene;Cell Line;Cell Physiology;Cell secretion;Cell surface;Cells;Chemotaxis;Chronic;Citrobacter;Coculture Techniques;Collaborations;Colon;Communicable Diseases;Complex;Data;Developed Countries;Developing Countries;Development;Diarrhea;diarrheal disease;disease model;enteric pathogen;enteroaggregative Escherichia coli;enterotoxigenic Escherichia coli;Epithelial Cells;Epithelium;Escherichia coli;Escherichia coli Infections;Event;Exocytosis;Family;Flow Cytometry;Gastroenterologist;Gene Silencing;Generations;Genes;Genetic;Glycoproteins;Goblet Cells;Growth;gut colonization;gut inflammation;Human;Immunologist;Immunology;immunoregulation;Impaired cognition;Impairment;Infection;Inflammation;Inflammatory;insight;Intervention;Intestinal Mucosa;Intestines;knock-down;Lectin;Leukocytes;Macrophage;MAP3K7 gene;Maryland;Mediating;Microscopy;migration;Modeling;monolayer;mouse model;Mucin 1 protein;Mucin-2 Staining Method;Mucins;Mucous body substance;multidisciplinary;neutrophil;Outcome;pathogen;Pathogenesis;pathogenic Escherichia coli;Penetration;pharmacologic;Play;Process;Productivity;Property;Protease Inhibitor;receptor;Research Personnel;Role;Salmonella;Serine Protease;Serine Proteinase Inhibitors;Shigella;Shigella flexneri;Shigella Infections;Signal Pathway;Signal Transduction;Specialist;synergism;System;Therapeutic Intervention;Thinness;transcriptomics;Traveler's diarrhea;Universities;Virginia;Virulence Factors;WFDC2 gene;Work

PROJECT_TITLE: Immunomodulatory role of Pic in EAEC Pathogenesis


ADMINISTERING_IC: DC

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Clinical Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative Vocal fatigue (VF) is among the most common voice-related complaints among individuals who rely on their voices to make a living (teachers, singers, etc.) and is implicated as an etiologic and/or reactive component in most common voice disorders. This project will use a combination of an existing ambulatory voice monitoring dataset and newly acquired data to quantify vocal function and behaviors that are associated with the causes and impact on phonatory mechanisms of VF among patients with voice disorders and vocally typical individuals. Achieving the goals of this project will lay the groundwork for the development of new clinical tools for preventing, assessing, and alleviating VF, which will be particularly valuable for professionals in occupations requiring heavy voice use.

PI_NAMEs: GHASEMZADEH, HAMZEH  (contact)

PROGRAM_OFFICER_NAME: RIVERA-RENTAS, ALBERTO L

PROJECT_TERMS: Accelerometer;Acoustics;Adult;Affect;Ambulatory Monitoring;Behavior;behavior prediction;Characteristics;Clinical;Clinical Management;clinical predictors;Compensation;Consensus;Data;data acquisition;Data Set;Databases;Deterioration;Development;disability;Etiology;Exhibits;experience;Fatigue;Female;Goals;Health Care Costs;Image;improved;Individual;insight;Intuition;Judgment;Knowledge;Laboratories;Laboratory Study;Life;Loudness;Machine Learning;machine learning framework;male;Measurement;Measures;Medical Care Costs;Modality;Modeling;Monitor;multimodal data;multimodality;Neck;novel;novel strategies;Occupations;Pain;Participant;Patients;Pattern;Periodicals;Persons;Phase;predictive modeling;prevent;Productivity;Protocols documentation;Recovery;Reporting;Rest;Series;Shoulder;societal costs;Speed;Stress Tests;supervised learning;Surface;Symptoms;System;teacher;Time;tool;Training Programs;Variant;vibration;vocal cord;Voice;Voice Disorders;Voice Quality;wireless sensor;Work

PROJECT_TITLE: Objective assessment of vocal fatigue in laboratory and real-world settings

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


ED_INST_TYPE: SCHOOLS OF MEDICINE

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases;Sexually Transmitted Infections

ORG_CITY: CHICAGO

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Narrative  The pathogenic Neisseria are obligate human pathogens with a long evolutionary history within human populations. The studies outlined in this proposal will continue our investigations into the molecular mechanisms used to replace one pilin type with another following high-frequency nonreciprocal recombination events, which allows the organism to evade the adaptive immune system and continually infect susceptible individuals.

PI_NAMEs: SEIFERT, HANK S. (contact)

PROGRAM_OFFICER_NAME: VINCENT, LEAH REBECCA

PROJECT_TERMS: Adaptive Immune System;Amino Acid Sequence;Antigenic Diversity;Antigenic Variation;Bacteria;Bacterial Genes;Biological Models;Biology;Borrelia;cell type;Cells;Chromosomes;comparative;Conversion disorder;Diploidy;Disease;DNA;DNA biosynthesis;DNA Repair;DNA replication fork;DNA Structure;Enteral;Epididymitis;Event;Evolution;Fimbriae Proteins;Frequencies;fungus;Gene Conversion;Gene Expression;Gene Frequency;Generations;Genes;Genetic Recombination;Genetic Transcription;Genome;Genome Stability;Genomics;Gonorrhea;Grant;Guanine;high risk;Host Defense;Human;human pathogen;Immune Evasion;Immunoglobulins;Individual;Infection;Investigation;Life;Malignant - descriptor;malignant state;Mammalian Cell;Mediating;men;Modeling;Molecular;mutant;Mycoplasma;Nasopharynx;Neisseria;Neisseria gonorrhoeae;Neisseria meningitidis;nucleic acid structure;Oncogenes;Organism;Outcome;Parasites;pathogen;Pathogenesis;Pathogenicity;Pelvic Inflammatory Disease;Persons;Phase;Pilum;Population;Predisposition;Process;Proteins;Recombinants;recombinational repair;Recording of previous events;repaired;resident commensals;RNA;Role;Sexually Transmitted Agents;Sexually Transmitted Diseases;Small RNA;Structure;Surface Antigens;System;T-Cell Receptor;telomere;Testing;Textbooks;transmission process;Treponema;Variant;Virulence Factors;Woman;Work

PROJECT_TITLE: Mechanisms of Gonococcal Pilin Antigenic and Phase Variation

STUDY_SECTION: PCMB

STUDY_SECTION_NAME: Prokaryotic Cell and Molecular Biology Study Section[PCMB]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Coronaviruses;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: STANFORD

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: PROJECT NARRATIVE The role of natural killer (NK) cells in the immune response to COVID-19 is not yet clear. This proposed work will use replication-competent SARS-CoV-2 to investigate the immune evasion strategies of SARS-CoV-2, assess the impact of COVID-19 severity on primary NK cell responses, and identify the mechanisms underlying the activated and exhausted phenotype seen in the NK cells of severe COVID-19 patients. These experiments will clarify the functional role of NK cells in COVID-19, providing crucial insights into how vaccination and therapeutic strategies should seek to modulate NK cell responses in this disease.

PI_NAMEs: LEE, MADELINE JANE (contact)

PROGRAM_OFFICER_NAME: ARNOLD, MICHELLE MARIE

PROJECT_TERMS: 2019-nCoV;Activated Natural Killer Cell;acute COVID-19;Affect;Automobile Driving;Biological Assay;biosafety level 3 facility;Cell Communication;cell killing;cell type;Cells;Cellular biology;Coculture Techniques;cohort;COVID-19;COVID-19 impact;COVID-19 mortality;COVID-19 patient;COVID-19 severity;cytotoxic;cytotoxicity;Data;Disease;Down-Regulation;exhaust;exhaustion;experimental study;Functional disorder;Future;Immune;Immune Evasion;Immune response;Immune system;Impairment;In Vitro;insight;Knowledge;Ligands;Lung;Measures;Mediating;Mediator;migration;monocyte;Natural Killer Cells;NK Cell Activation;Pathogenesis;Pathologic;Pathology;Patients;Peripheral;Phenotype;Play;Predisposition;prevent;Qualifying;receptor;Receptor Cell;Research;response;Role;SARS-CoV-2 infection;severe COVID-19;Severities;Severity of illness;System;Testing;Therapeutic;therapeutic development;tumor;Tumor Immunity;Vaccination;Viral;Viral Physiology;virology;Virus Diseases;Work

PROJECT_TITLE: Defining the role of natural killer cells in COVID-19


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Immunization;Infectious Diseases;Pediatric;Prevention;Rare Diseases;Vaccine Related

PI_NAMEs: BARRY, EILEEN M. (contact)

PROJECT_TERMS: 5 year old;Animal Model;Attenuated;Attenuated Vaccines;Biopsy;burden of illness;Cells;Cessation of life;Characteristics;Child;Clinical;Coculture Techniques;Complex;Dendritic cell activation;Dendritic Cells;Developing Countries;Diarrhea;Disease;Disease Progression;Dysentery;Endemic Diseases;Engraftment;Epithelium;Escherichia coli;Evaluation;Event;Funding;gastrointestinal;Gastrointestinal Physiology;global health;Health Priorities;Human;Immune;immune activation;Immune response;Infection;Inflammatory Response;Innate Immune Response;insight;Intervention;intestinal epithelium;intraepithelial;Invaded;Kinetics;Lymphocyte;M cell;Macrophage;Modeling;Multi-Drug Resistance;Mutation;novel;pathogen;Pathogenesis;Pathogenicity;Patients;Physiological;Population;preventive intervention;Process;response;Series;Shigella;Shigella flexneri;Shigella Infections;Shigella sonnei;Shigella Vaccines;Symptoms;synergism;System;Therapeutic Intervention;therapy development;tool;transcytosis;uptake;vaccine acceptance;vaccine candidate;vaccine development;vaccine evaluation;Virulence Factors

PROJECT_TITLE: Modeling Shigella Interaction with Innate Cells in Enteroid Co-Cultures to Inform Vaccine Development


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Immunization;Infectious Diseases;Rare Diseases;Vaccine Related

PI_NAMEs: FOULKE-ABEL, JENNIFER  (contact)

PROJECT_TERMS: Acute;adaptive immunity;Adhesions;Animals;anti-microbial peptide;Apical;Attention;Bacteria;beta-Defensins;burden of illness;Cancer cell line;cell type;Cells;Clinical;Clinical Research;Coculture Techniques;Cyclic AMP;Cyclic GMP;Cyclic Nucleotides;cytokine;design;Diarrhea;diarrheal disease;Disease;Disease Outbreaks;Drug Design;Enabling Factors;Enteral;enteroaggregative Escherichia coli;enterotoxigenic Escherichia coli;Enterotoxins;Environment;Epithelium;Escherichia coli;Escherichia coli Infections;extracellular;follow-up;Functional disorder;Goals;gut bacteria;Host Defense;Human;human model;IL8 gene;Image;Immune;immune activation;Immune response;Immunization;Immunology;improved;Infection;Inflammation;Inflammatory;Innate Immune Response;innovation;insight;Intention;Interleukin-1 beta;Intervention;intestinal epithelium;Intestines;intraepithelial;Investigation;Knowledge;Macrophage;Methodology;microbiome;model development;Modeling;Molecular;monocyte;monolayer;Multicenter Studies;neutrophil;novel;Oxygen;pathogen;Pathogenesis;pathogenic bacteria;Pathogenicity;Peptides;peripheral blood;Phase;Phenotype;Physiological;Population;pre-clinical;Production;Protein Subunits;Reaction;Regulation;Research;response;Role;scaffold;Second Messenger Systems;Shigella;Shigella Infections;Signal Induction;Signal Transduction;Small Intestines;synergism;targeted treatment;Therapeutic;therapeutic target;therapy development;Tissues;tool;Transcript;Vaccine Design;vaccine strategy;Vaccines;Variant;Work;γδ T cells

PROJECT_TITLE: Innate defenses against enterotoxigenic E. coli as potential therapeutic contributors


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: OVERALL NARRATIVE In collaboration with residents and representatives of communities living in Persistent Poverty in Alabama, the University of Alabama at Birmingham (UAB)'s Center for Cancer Control in Persistent Poverty Areas (C3P2) will build a research program and research capacity to improve cancer prevention and control in these communities. Starting from nine urban Persistent Poverty Census Tracts identified as such by the NCI, the C3P2 goal is to support transdisciplinary multi-level research to address Social Determinants of Health, in particular addressing poor living environments, and to provide efficacious adapted interventions to enhance health promotion and adoption of healthy behaviors across the cancer continuum from prevention to survivorship.

PI_NAMEs: FOUAD, MONA N.;PISU, MARIA  (contact)

PROGRAM_OFFICER_NAME: HARDESTY, REBECCA ANNE

PROJECT_TERMS: Achievement;Address;Adoption;Affect;Alabama;anti-cancer research;Area;Attention;Behavior;Behavioral;Cancer Burden;Cancer Center;Cancer Control;Cancer Control Research;cancer health disparity;cancer prevention;cancer risk;career;Censuses;Collaborations;Colorectal Cancer;Common Data Element;Communities;community academic partnership;community advisory board;community engagement;community living;Complex;County;data tools;Development;Dissemination and Implementation;early experience;Education;effectiveness testing;efficacious intervention;Ensure;Environment;Evaluation;evidence base;Evidence based practice;experience;Geographic Locations;Goals;Health behavior change;health care availability;health care service utilization;Health Promotion;High Prevalence;improved;Incidence;Individual;Infrastructure;inner city;innovation;Institution;Intervention;Knowledge;Leadership;Malignant Breast Neoplasm;Malignant neoplasm of prostate;Malignant Neoplasms;Measures;Mentorship;Modeling;Monitor;mortality;mortality risk;multidisciplinary;National Cancer Institute;neighborhood disadvantage;Obesity;Obesity associated cancer;Outcome;Personal Satisfaction;Physical environment;Pilot Projects;poor communities;Population;Positioning Attribute;Poverty;Poverty Areas;prevent;Prevention;program dissemination;programs;Research;Research Methodology;Research Personnel;Research Project Grants;Resources;Risk Factors;Role;Rural;Rural Community;social;social cohesion;Social Environment;social health determinants;social structure;Stress;supportive environment;survivorship;synergism;System;therapy design;tool;Training;Universities;University of Alabama at Birmingham Cancer Center;Work


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Genetics;Neurosciences;Women's Health Research

ORG_CITY: Newark

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF DELAWARE

ORG_STATE: DE

PHR: Project Narrative A female’s prior mating experience––positive or negative––informs her subsequent mating strategy, but how the brain computes and encodes this complex assignment is unknown. The proposed study will elucidate the molecular and neural mechanisms that underpin sexual reward in the brain of female Drosophila, which will advance our understanding on the rewarding aspect of mating behavior and provide novel insights into fundamental principles for the encoding and regulation of natural reward.

PI_NAMEs: SHAO, LISHA  (contact)

PROGRAM_OFFICER_NAME: STEPANEK, LAURIE ELIZABETH

PROJECT_TERMS: Affect;Anatomy;Animals;Behavior;Behavioral Paradigm;behavioral response;biological adaptation to stress;Biological Models;Brain;Candidate Disease Gene;Collection;Complex;Copulation;Desire for food;Drosophila genus;Drosophila melanogaster;Exhibits;experience;Exposure to;Female;fly;Generations;Genes;Genetic;Goals;insight;interdisciplinary approach;Learning;Link;mating behavior;Molecular;Molecular Genetics;Morphology;neural;Neural Pathways;neuromechanism;Neurons;novel;Partner in relationship;Pathologic;Pathway interactions;Peptides;Personal Satisfaction;Physiology;Regulation;Rewards;social;Stimulus;Structure;tool;transcriptome;Update;Visualization

PROJECT_TITLE: Elucidating the molecular and neural structure of female sexual reward

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-L(55)R]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Obesity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: PISU, MARIA  (contact)

PROJECT_TERMS: Alabama;Behavior Therapy;Cancer Center;Cancer Control;Cancer Survivor;Collaborations;Communication;Communities;community advisory board;community engagement;Comprehensive Cancer Center;Development;Doctor of Philosophy;Economic Burden;effective intervention;Ensure;Evaluation;experience;Funding;Goals;Health;Health Disparities Research;Health Policy;improved;Infrastructure;innovation;Intervention;Lead;Leadership;Malignant Neoplasms;meetings;Mentors;minority health;minority health disparity;National Center for Complementary and Integrative Health;National Institute on Minority Health and Health Disparities;Obesity;Outcome;outreach;Pilot Projects;Policy Research;Poverty;Poverty Areas;Prevention;Preventive Medicine;Principal Investigator;recruit;Research;Research Personnel;Research Project Grants;Resource Sharing;Science;success;survivorship;synergism;Universities;Well in self;Work

PROJECT_TITLE: Administrative Core-001


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Data Science;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Social Determinants of Health

PI_NAMEs: OATES, GABRIELA R (contact)

PROJECT_TERMS: American;Area;Automobile Driving;Bioinformatics;Biometry;Cancer Center;Cancer Control;Cancer Control Research;cancer health disparity;career;Censuses;Characteristics;Collaborations;Collection;Common Data Element;community engagement;community partners;Community Surveys;Consultations;cost effective;Data;data integration;data interoperability;data management;data quality;data sharing;data tools;data visualization;Databases;design;Development;Dissemination and Implementation;Education;Ensure;Evaluation;Evaluation Research;Evidence based intervention;experience;Fostering;Goals;implementation framework;implementation outcomes;implementation strategy;indexing;Individual;instrument;interest;interoperability;Link;Malignant Neoplasms;Maps;Measures;Mentorship;Methodology;Modeling;Neighborhoods;Online Systems;Outcome;Participant;Pathway interactions;PhenX Toolkit;Pilot Projects;Play;Policies;Poverty;Poverty Areas;Privacy;Productivity;Protocols documentation;Quality Control;Reporting;repository;Research;Research Design;Research Methodology;Research Personnel;Research Project Grants;Research Support;Research Training;Risk Factors;Role;Scientist;screening;Services;social;Statistical Data Interpretation;Statistical Methods;Statistical Models;synergism;Testing;tool;Training Activity;United States National Institutes of Health;University of Alabama at Birmingham Cancer Center;Visualization

PROJECT_TITLE: Research and Methods Core-002


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Emerging Infectious Diseases;Infectious Diseases

ORG_DEPT: CHEMISTRY

PHR: Project Narrative Relevance to human health: We develop and apply new physical methods for the quantitative analysis of biological systems. We apply these methods to a broad range of systems, in particular enzymes related to antibiotic resistance and the mechanism of viral membrane fusion.

PI_NAMEs: BOXER, STEVEN G. (contact)

PROGRAM_OFFICER_NAME: FLICKER, PAULA F

PROJECT_TERMS: Active Sites;Address;analytical method;Antibiotic Resistance;Antibiotics;Applications Grants;Architecture;Area;Biological;Biological Assay;biological systems;biophysical analysis;Biophysics;Catalysis;Communicable Diseases;complex biological systems;coping;design;Development;electric field;Electrostatics;enzyme model;Enzymes;Evolution;Freedom;Genetic Recombination;Health;Human;imaging modality;Influenza A virus;Lactamase;Lateral;Lipids;macromolecule;man;Maps;mass spectrometric imaging;Membrane;Membrane Fusion;membrane model;Methods;model development;molecular assembly/self assembly;novel;novel strategies;Optics;optogenetics;Parents;particle;Pathway interactions;Process;Property;Proteins;Research;Resolution;Spectrum Analysis;structural biology;System;Time;Viral;Virus;Work

PROJECT_TITLE: Biophysical studies of macromolecules and molecular assemblies

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-V(55)R]


NIH_SPENDING_CATS: Genetics

ORG_CITY: HANOVER

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: Deregulation of phosphorylation signaling in cell division has been implicated in many human diseases, including cancer and birth defects. In this application, we will advance a quantitative chemical proteomics strategy to enable us to interrogate key mitotic kinases, identify their substrates, uncover the regulation of dynamic phosphorylation via specific opposing phosphatases, and elucidate phosphorylation signaling networks of key mitotic regulatory kinases.

PI_NAMEs: GERBER, SCOTT A. (contact)

PROGRAM_OFFICER_NAME: MASKERI, BAISHALI

PROJECT_TERMS: anaphase-promoting complex;Apical;aurora B kinase;aurora kinase A;Biochemical;Bioinformatics;Biological;Biological Process;Cell division;Cell Physiology;Cells;Centrosome;Chemicals;cohesion;Communities;Complex;Congenital Abnormality;Cyclin B;Cytokinesis;Dedications;Docking;Excision;Goals;human disease;interest;Kinesin;Kinetochores;Malignant Neoplasms;Mediator;Microtubules;Mitosis;Mitotic;Motor;Peptide Hydrolases;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphotransferases;Play;Post-Translational Protein Processing;protein function;Protein Kinase;Protein Phosphatase 2A Regulatory Subunit PR53;protein phosphatase 6;Proteins;Proteomics;recruit;Regulation;Research;Research Personnel;Resources;restraint;Role;Scaffolding Protein;Signal Transduction;Sister Chromatid;Structural Protein;ubiquitin-protein ligase

PROJECT_TITLE: Phosphorylation signaling in cell division

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Physical Activity;Prevention;Social Determinants of Health

PI_NAMEs: BATEMAN, LORI BRAND (contact)

PROJECT_TERMS: Academy;African American;Alabama;allostatic load;Area;Behavior;biological adaptation to stress;Biological Markers;Black American;built environment;Businesses;Cancer Center;Cancer Control;cancer health disparity;cancer prevention;cancer risk;Caring;Censuses;Chronic stress;Cities;Communities;community engagement;Community Health Aides;community intervention;comparison control;Data;design;Disadvantaged;Disparity;Electronic Health Record;Emergency department visit;Environment;Evaluation;Event;Excision;Focus Groups;Goals;Grant;Green space;group intervention;Health behavior;Health care facility;health care service utilization;Health system;Hospitalization;improved;indexing;Intervention;Knowledge;Leadership;Lighting;Local Government;Malignant Neoplasms;Measures;member;Methods;Modification;Needs Assessment;Neighborhoods;Not Hispanic or Latino;Outcome;Patient Self-Report;perceived stress;Perception;Physical activity;poor communities;Population;post intervention;Poverty;Poverty Areas;Prevention;prevention service;Preventive care;Race;Research;Research Project Grants;Risk Factors;Safety;Sampling;Screening for cancer;social;social cohesion;Social Environment;social health determinants;social vulnerability;Socialization;Stress;Surveys;Testing;urban area;virtual;walkability

PROJECT_TITLE: Research Project 1


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

PHR: Narrative The research proposes to determine atomic resolution molecular structures of amyloid peptides and proteins associated with Alzheimer’s disease and their interaction with the antibody Aducanumab, dialysis related amyloidosis (beta-2-microglobulin and ?N6-b2m) as well as some model amyloid systems. In addition, we propose to continue to develop the methodology to perform the structural experiments focusing on 1H detection of dipolar recoupled spins and 17O spectroscopy.

PI_NAMEs: GRIFFIN, ROBERT GUY (contact)

PROGRAM_OFFICER_NAME: YANG, AUSTIN JYAN-YU

PROJECT_TERMS: 2,4-Dinitrophenol;Aducanumab;Alzheimer's Disease;Alzheimer's disease brain;Amino Acids;Amyloid;Amyloid beta-Protein;Amyloid Fibrils;amyloid peptide;Amyloid Proteins;amyloid structure;Amyloidosis;Antibodies;Arctic mutation;beta-2 Microglobulin;Binding;Biological Models;Brain;catalyst;Chemicals;Computer software;Coupled;Coupling;Cryoelectron Microscopy;Detection;Development;Dialysis procedure;Early Onset Alzheimer Disease;Exhibits;experimental study;flexibility;Frequencies;Genetic Polymorphism;Globulins;Grant;Growth;Hydration status;in vivo;Investigation;Isotopes;Label;Magic;Measurement;Measures;method development;Methodology;Methods;Modeling;Molecular Structure;Morphology;mutant;N-terminal;next generation;NMR Spectroscopy;paragon;Pathologic;Peptides;Polymorph;Population;Probability;Process;Proteins;PrP;Publishing;Reproducibility;Research;Resolution;Sampling;Signal Transduction;solid state nuclear magnetic resonance;Spectrum Analysis;Structure;sup35;System;Tail;Techniques;Testing;Thermodynamics;tool;Torsion;Variant;yeast prion

PROJECT_TITLE: Solid State NMR Studies of Amyloid Proteins

STUDY_SECTION: MSFB

STUDY_SECTION_NAME: Macromolecular Structure and Function B Study Section[MSFB]


ED_INST_TYPE: GRADUATE SCHOOLS

ORG_CITY: KINGSTON

ORG_NAME: UNIVERSITY OF RHODE ISLAND

ORG_STATE: RI

PHR: PROJECT NARRATIVE – OVERALL Since the STEEP SRP Center was first funded in 2017, PFAS have emerged as national priority pollutants, with the EPA and states grappling with setting PFAS standards for drinking water while assessing the human and ecological risk linked to emissions from contaminated sites, point, and diffuse sources. STEEP II builds on the successful collaborative it established within the first STEEP SRP Center (STEEP I) to further advance the science, training, engagement, and outreach in support of SRP mandates. In order to successfully tackle the complex biomedical and environmental science surrounding PFAS, and provide actionable insight, tools, and solutions, STEEP II’s research is focused on problem-based, solution-oriented PFAS research that covers critical health effects, mechanistic studies, risk assessment, detection and remediation of PFAS.

PI_NAMEs: LOHMANN, RAINER  (contact)

PROGRAM_OFFICER_NAME: HENRY, HEATHER F

PROJECT_TERMS: absorption;Accounting;Address;Adverse effects;Affect;age related;Air;analytical tool;aqueous;Area;Atmosphere;Awareness;base;bioaccumulation;Biological Markers;Breast Feeding;Chemicals;Child;Cods;cohesion;cohort;Collaborations;Communication;Communication Tools;Communities;community engagement;Complex;Coronavirus;Data;Data Analyses;data management;Delaware;Dependence;Detection;Development;Diffuse;drinking water;Dust;Education;effectiveness evaluation;Endocrine;Endocrine disruption;environmental chemistry;Environmental Engineering technology;Environmental Science;equity, diversity, and inclusion;Excretory function;experience;exposed human population;exposure pathway;Exposure to;Faeroe Islands;FAIR principles;Feedback;Film;Fishes;Food;Fostering;Funding;Goals;Great Lakes Region;ground water;Growth;Health;high school;Human;Human Milk;Immunologic Markers;immunotoxicity;improved;indoor air;Infant;innovation;insight;Intervention;Joints;Knowledge;Laboratories;Link;Measurement;Measures;Mentors;Mentorship;Metabolic;Metabolism;Milk;Modeling;Molecular;novel;Outcome;outreach;oxidation;Paper;Pathway interactions;Policies;pollutant;Poly-fluoroalkyl substances;predictive modeling;prevent;Prevention strategy;Privatization;Process;programs;Public Health;remediation;Research;Research Project Grants;Resources;response;Rhode Island;Risk;Risk Assessment;Rodent;Safety;Science;Serum;Shellfish;Signal Recognition Particle;Site;Soil;Source;Superfund;superfund site;Time;Tissues;tool;Toxicokinetics;Training;Translating;Translational Research;Tribes;Uncertainty;United States National Institutes of Health;Universities;uptake;Vaccination;Vulnerable Populations;Wampanoag;Water;Work

PROJECT_TITLE: Sources, Transport, Exposure & Effects of PFAS (STEEP) Center - RENEWAL


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Physical Activity;Prevention;Social Determinants of Health

PI_NAMEs: ROGERS, LAURA Q (contact)

PROJECT_TERMS: Address;Alabama;Behavioral;Black Populations;Black race;Body mass index;Breast;built environment;Cancer Burden;Cancer Center;Cancer Control;cancer health disparity;Cancer Survivor;cancer type;Censuses;Child Care;Client;Colorectal;Communities;community advisory board;community organizations;community partners;cost;design;Diet;Discrimination;Disparity;efficacious intervention;Environment;Evaluation;exercise intervention;experience;Exploration, Preparation, Implementation, and Sustainment;Family;Focus Groups;Friends;Goals;Health behavior;health inequalities;Health Personnel;Health Promotion;implementation barriers;implementation facilitators;implementation framework;implementation outcomes;implementation research;implementation strategy;improved;Individual;Infrastructure;Institution;Knowledge;Malignant Neoplasms;Methods;Modeling;mortality;Not Hispanic or Latino;Obesity;Outcome;Outcome Assessment;Pathway interactions;Physical activity;Physical environment;physical inactivity;Policies;Population;Poverty;Poverty Areas;Process;Program Appropriateness;programs;prospective;Quality of life;Readiness;Recording of previous events;Reduce health disparities;Research;Research Design;Research Personnel;Research Project Grants;Resources;Risk;Risk Factors;Safety;Services;social;Social Environment;social health determinants;Survivors;therapy design;Transportation;Unhealthy Diet;Work;working group

PROJECT_TITLE: Research Project-002


NIH_SPENDING_CATS: Endocrine Disruptors;Foodborne Illness

PHR: PROJECT NARRATIVE – PROJECT 1 EXPOSURE Results of this project will help identify populations potentially at risk for elevated PFAS exposures through contaminated drinking water/ fish and enhanced atmospheric PFAS deposition. Work associated with this project will investigate the downstream impacts of PFAS contamination from aqueous film forming foam (AFFF) use at the Joint Base Cape Cod, which is a designated Superfund Site for PFAS. Improved risk assessment methods, particularly for polyfluoroalkyl precursors that degrade into terminal PFAS, developed as part of this project will be directly useful for managing contaminated site remediation goals and the development of public health guidance. 1

PI_NAMEs: SUNDERLAND, ELSIE MARECA (contact)

PROJECT_TERMS: Acids;Address;Affect;Air;anthropogenesis;aqueous;Atmosphere;base;Bayesian Analysis;Binding;bioaccumulation;Biological;Biological Assay;Biota;Budgets;Carbon;Chemicals;Child;Chromatography;Cods;Collaborations;contaminated drinking water;contaminated seafood;cost;Data;data management;Deposition;Detection;Development;drinking water;Ecosystem;Endocrine;Engineering;Environmental Exposure;Environmental Risk Factor;exposed human population;exposure pathway;Exposure to;Film;Fishes;Food Webs;Goals;Hazardous Substances;Health;Human;Hybrids;immune function;improved;Individual;Industry;innovation;Ions;Joints;Knowledge;Length;Link;Location;manufacture;manufacturing facility;Mass Spectrum Analysis;Measurement;Measures;Metabolism;Methods;Methylmercury Compounds;Modeling;Monitor;novel;Output;oxidation;Pathway interactions;Performance;Phase;Phospholipids;Phytoplankton;Poly-fluoroalkyl substances;Polychlorinated Biphenyls;Population;Practice Management;Prevalence;Privatization;Production;programs;Proteins;Public Health;receptor;Refuse Disposal;remediation;Research;Resolution;Resources;Risk;Risk Assessment;Sampling;Scientist;Seafood;Signal Recognition Particle;Site;Source;Statistical Methods;Statistical Models;Structure;superfund site;Techniques;Time trend;Tissues;tool;training opportunity;Tribes;United States;vector;virtual;Wampanoag;Water;Water Supply;Work

PROJECT_TITLE: Assessing the Contribution of Polyfluoroalkyl Precursors to Diverse PFAS Exposures near Contaminated Sites


NIH_SPENDING_CATS: Asthma;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Effects of Indoor Air Pollution;Lung;Pediatric;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Asthma morbidity continues to be a major public health problem among low-income minority children living in urban neighborhoods, and the major contributors are thought to be exposures to pest allergens and indoor pollution. With this current proposal, we will extend our previous Mobility Asthma Project (MAP, R01 ES026170-05), where we followed children with asthma as they entered into the Baltimore Housing Mobility Program and moved to low poverty neighborhoods, to determine if these reductions in home exposures and asthma outcomes are sustained over a 4 to 7 year follow-up period, whether lung function growth is changed with mobility, and whether parent/caregiver stress may mediate or modify the effects of changes in indoor exposures on asthma outcomes. The proposed project is strongly positioned to both influence housing policy around mobility and has implications for interventions designed to reduce asthma morbidity in children who remain living in high-poverty neighborhoods.

PI_NAMEs: KEET, CORINNE ;MATSUI, ELIZABETH C.;POLLACK, CRAIG EVAN (contact)

PROGRAM_OFFICER_NAME: QUINN, ASHLINN KO

PROJECT_TERMS: Address;Adult;Allergens;Asthma;Baltimore;Birth;burden of illness;caregiver stress;Child;Childhood Asthma;cohort;Communities;Data;development policy;Discrimination;Disparity;Enrollment;Environmental Exposure;ethnic minority population;Exposure to;family support;follow-up;Follow-Up Studies;Growth;Home;Housing;improved;indoor exposure;inner city;Intervention;Life Expectancy;Long-Term Effects;Low income;lung health;Measures;Mediating;Medicaid;minority children;Morbidity - disease rate;mouse allergen;Natural History;Neighborhoods;Outcome;Parents;Participant;participant enrollment;Policies;Pollution;poor communities;Positioning Attribute;Poverty;programs;Prospective, cohort study;Psychosocial Stress;Public Health;pulmonary function;Role;segregation;Stress;stressor;Symptoms;therapy design;Time;tool;urban children;Urban Population;urban setting

PROJECT_TITLE: The effect of a housing mobility program on environmental exposures and asthma morbidity among low-income minority children

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-C(07)]


NIH_SPENDING_CATS: Breastfeeding, Lactation and Breast Milk;Clinical Research;Endocrine Disruptors;Immunization;Pediatric;Prevention;Vaccine Related

PHR: PROJECT NARRATIVE – PROJECT 2 CRITICAL EFFECTS STEEP achievements support the notion that PFAS exposures incurred during early development can affect immune system and metabolic functions and trigger potential vaccine failure and metabolic abnormalities that may lead to infections, obesity, and osteoporosis, all of which constitute important public health problems. This project is conducting prospective studies of about 1000 children from two birth cohorts generated in the Faroe Islands, where PFAS exposures are investigated prenatally, via breastfeeding, and beyond, and clinical features and blood biomarkers are assessed to determine adverse effects of profiles of PFAS exposures. The aim is to identify windows of vulnerability related to developmental pathways at ages 5 and 14 years and to determine exposure-related outcomes as a basis for improved risk assessment and protection against exposures to these persistent environmental contaminants.

PI_NAMEs: GRANDJEAN, PHILIPPE ADAM (contact)

PROJECT_TERMS: 14 year old;5 year old;9 year old;Achievement;Adaptive Immune System;adipokines;Adult;Adverse effects;Affect;Age;Age Months;Antibodies;Antibody Formation;Antibody Response;Apolipoproteins C;Biological Markers;Birth;Blood;Blood specimen;Bone Mineral Contents;Breast Feeding;Child;Childhood;Cholesterol;Clinical;Clinical Data;clinical examination;clinical phenotype;clinically relevant;cohort;Cohort Studies;Communicable Diseases;COVID-19 severity;Data;Dependence;Development;Dual-Energy X-Ray Absorptiometry;early life exposure;Endocrine;Endocrine disruption;environmental chemical;Environmental Pollutants;epidemiology study;Equation;Etiology;Exposure to;Faeroe Islands;Frequencies;General Population;Genetic;Goals;Health;Human;Human Development;Human Milk;Human Papilloma Virus Vaccine;immune function;Immune system;Immune System Diseases;immune system function;immunodeficiency;Immunologic Markers;immunotoxicity;improved;Incidence;infancy;Infection;Inflammation;inflammatory marker;insight;Insulin-Like Growth Factor I;Joints;Lactation;Life;Link;Lipids;Lymphocyte Count;Measures;Metabolic;Metabolic Diseases;Modeling;next generation;Non-Insulin-Dependent Diabetes Mellitus;Obesity;Osteoporosis;Outcome;Pathogenesis;Pathway interactions;Pattern;Placenta;Poly-fluoroalkyl substances;postnatal;Prediabetes syndrome;Predisposition;Pregnancy;prenatal;Prevention;prospective;Prospective Studies;Puberty;Public Health;Regression Analysis;Reporting;Research;Risk;Risk Assessment;Rodent;Role;Sampling;Scanning;Serum;Serum Markers;sexual dimorphism;Signal Recognition Particle;Skinfold Thickness;Source;Statistical Methods;Time;Toxoids;Umbilical Cord Blood;Vaccination;vaccine failure;vaccine-induced antibodies;Vaccines

PROJECT_TITLE: Critical effects associated with developmental PFAS exposure profiles


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Social Determinants of Health

PI_NAMEs: BAKITAS, MARIE ANNE (contact)

PROJECT_TERMS: Address;African American;Alabama;anti-cancer research;Applications Grants;Area;Black race;cancer care;Cancer Center;Cancer Control;cancer health disparity;career;career development;Clinic;Collaborations;Communities;community based participatory research;Comprehensive Cancer Center;Continuing Education;Dedications;Development;disability;doctoral student;Education;Educational workshop;Ensure;experience;Face;Faculty;Fostering;Funding;Goals;Health Disparities Research;Hispanic;Institution;interest;Investments;Latinx;Low income;Malignant Neoplasms;Manuscripts;marginalized population;medical schools;Medicine;meetings;Mentors;minority health;Participant;Persons;Pilot Projects;Population;Population Heterogeneity;Postdoctoral Fellow;postdoctoral investigator;Poverty;Poverty Areas;pre-doctoral;Preparation;Prevalence;Process;Research;Research Methodology;Research Personnel;Research Project Grants;Resource Sharing;Resources;Science;Scientist;skills;symposium;Training;Training and Education;Training Programs;Universities;University of Alabama at Birmingham Cancer Center;Work;Writing

PROJECT_TITLE: Career Enhancement Core-001


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Asthma;Biotechnology;Clinical Research;Genetics;Human Genome;Lung;Patient Safety;Precision Medicine

ORG_CITY: LA JOLLA

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: NARRATIVE Asthma affects over 300 million individuals worldwide and accounts for an estimated $82 billion in direct health care costs in the United States annually. This study seeks a thorough understanding of the role of small circulating cell-cell signaling molecules called microRNAs and of microRNA genetics in the control of asthma symptoms and in symptoms response to therapy. Since microRNAs are both stable in the circulation and may be targeted, this study has the potential to uncover novel biomarkers and therapies for the persistently symptomatic person with uncontrolled asthma, thereby decreasing asthma costs, morbidity, and mortality.

PI_NAMEs: TANTISIRA, KELAN G (contact)

PROGRAM_OFFICER_NAME: GAN, WEINIU

PROJECT_TERMS: Absenteeism;Absenteeism at work;Affect;airway epithelium;airway inflammation;Alleles;analytical method;Asthma;asthma exacerbation;asthmatic;asthmatic airway;asthmatic patient;Automobile Driving;Bayesian Modeling;behavioral economics;bench to bedside;Biogenesis;Biological;Biological Markers;Biology;Blood;Body Fluids;bronchial epithelium;cell type;Cells;Childhood Asthma;circulating microRNA;Circulation;Clinical;Clinical Data;clinical translation;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;Cohort Studies;Complex;cost;Costa Rica;Cross-Sectional Studies;cytokine;Data;Development;differential expression;Direct Costs;Disease;Enrollment;Epidemiology;epigenetic regulation;Epithelial Cells;Frequencies;Future;Gene Expression;Gene Targeting;Genes;Genetic;Genetic Polymorphism;genetic variant;Genetic Variation;genome resource;genome sequencing;genome wide association study;Genomics;Glucocorticoids;Goals;Guidelines;Health Care Costs;high risk;Human;Immune;Individual;Inflammation;Inflammatory;inhibitor;insight;intercellular communication;Investigation;Life;Link;Logistic Regressions;Longitudinal Studies;Maps;MicroRNAs;miRNA expression profiling;Modeling;Molecular;Morbidity - disease rate;mortality;mRNA Transcript Degradation;mRNA Translation;novel;novel marker;novel therapeutics;overexpression;Participant;Pathogenesis;Pathway Analysis;Persons;Pharmacogenomics;Pharmacotherapy;Phenotype;Physiological;Play;point of care;predictive marker;Prognosis;prognostic assays;Prognostic Marker;prognostic method;programs;Quality of life;Recommendation;Repression;Research;response;Risk;RNA;Role;Sampling;Schools;Serum;Signal Pathway;Signal Transduction;Signaling Molecule;Site;Socioeconomic Factors;success;symptom treatment;Symptoms;Testing;Therapeutic;therapeutic miRNA;Time;Tissues;Translational Repression;treatment guidelines;treatment response;United States;Untranslated RNA;Variant;whole genome

PROJECT_TITLE: Genomics and Pharmacogenomics of Symptoms in Asthma

STUDY_SECTION: IRAP

STUDY_SECTION_NAME: Infectious Diseases, Reproductive Health, Asthma and Pulmonary Conditions Study Section[IRAP]


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Clinical Research;Hematology;Infectious Diseases;Lung;Orphan Drug;Rare Diseases;Sepsis

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative  Acute respiratory syndrome (ARDS) is common in patients suffering from conditions such as major trauma, sepsis or shock and is the primary cause of death. The severity of lung injury remains a critical determinant of survival in patients suffering from ARDS and sepsis. This proposal seeks to identify and characterize a novel cell death pathway caused by a packaged delivery of Gasdermin D in microparticles by monocytes; thereby uncovering novel insights into ARDS mediated lung injury of septic patients and thus create new therapeutic opportunities to prevent and treat patients with ARDS and other inflammatory diseases.

PI_NAMEs: SARKAR, ANASUYA  (contact)

PROGRAM_OFFICER_NAME: ESPINOZA GRANDON, INGRID CECILIA

PROJECT_TERMS: Acute;Acute Lung Injury;Acute Respiratory Distress Syndrome;Alveolar;Behavior;Caspase;Cause of Death;Cell Death;Cell Death Induction;Cell Physiology;Cells;Cessation of life;Chemicals;Clinical;Data;Death Rate;Disease;Encapsulated;Endothelial Cells;Endothelium;exosome;extracellular;Foundations;Hematopoietic;Immune;In Vitro;Inflammatory;Injury;insight;Intensive Care Units;Link;Lung;lung injury;lung microvascular endothelial cells;lung preservation;lung vascular injury;Macrophage;Mediating;Modeling;Molecular;monocyte;mouse model;Mus;new therapeutic target;novel;novel therapeutics;particle;Pathogenicity;Pathway interactions;Patients;Phagocytes;pharmacologic;Phosphoproteins;Phosphorylation;Play;Polyubiquitination;Post-Translational Protein Processing;prevent;Proteins;Publishing;Purinoceptor;recruit;Regulation;respiratory;response;Role;Sepsis;sepsis induced ARDS;septic patients;Severities;Shock;Structure;Synapses;Syndrome;Testing;Therapeutic;therapeutically effective;Trauma;Ubiquitin;Vascular Diseases;vascular injury;Vesicle;Work

PROJECT_TITLE: GasderminD regulation of Acute Lung Injury

STUDY_SECTION: LIRR

STUDY_SECTION_NAME: Lung Injury, Repair, and Remodeling Study Section[LIRR]


NIH_SPENDING_CATS: Breastfeeding, Lactation and Breast Milk;Endocrine Disruptors

PHR: PROJECT NARRATIVE – PROJECT 3 MECHANISMS Per- and polyfluorinated alkyl substances (PFAS), have been detected in human serum and excreta, and some are associated with adverse health outcomes in humans. STEEP Project 3 (P3–Mechanisms) elucidates the cellular mechanisms by which PFAS are absorbed, retained, and are eliminated in the body to inform Projects 1, 2, and 4 for bioaccumulation modeling and enable predicting PFAS absorption, distribution, and excretion in humans. P3–Mechanisms will apply mechanistic approaches SRP Mandate #3 and SRP Mandate #4, as well as support interdisciplinary training.

PI_NAMEs: SLITT, ANGELA L (contact)

PROJECT_TERMS: ABCG2 gene;absorption;Acids;Address;Apple;Binding;Binding Proteins;bioaccumulation;Biological;Biological Assay;biological development;Birds;Bispecific Antibody 2B1;Blood;Breast Epithelial Cells;Carrier Proteins;Cells;Chemical Engineering;Chemicals;Cods;Communication;community engagement;Data;Detection;Development;Dietary Factors;Drug or chemical Tissue Distribution;Excretory function;experience;Fatty Acid-Binding Protein 1;fatty acid-binding proteins;Fatty Acids;Fishes;genetic risk factor;Goals;Half-Life;Hazardous Substances;Health;high throughput screening;Human;Human Milk;Impairment;improved;In Vitro;in vitro Assay;in vitro Model;in vivo;in vivo Model;inhibitor;Intestines;Juice;Kinetics;Knockout Mice;Knowledge;Lactation;Life;Liver;marine;Marketing;Mediating;method development;Methods;Milk;Modeling;Mus;novel;OATP Transporters;offspring;Organism;Outcome;perfluorooctanoic acid;Permeability;Pharmaceutical Preparations;pharmacologic;Pharmacy facility;Poly-fluoroalkyl substances;Property;Proteins;Research;Risk Assessment;Rodent;Science;screening;Serum;Serum Albumin;Signal Recognition Particle;Source;Techniques;Testing;Tissues;tool;Toxic effect;Toxicokinetics;Toxicology;Training;uptake;urinary;Urine;Validation;Variant;wasting;Water;Whales;Work;Xenobiotics

PROJECT_TITLE: Mechanisms of Exposure


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Rural Health;Social Determinants of Health

PROJECT_TERMS: Address;Alabama;Area;Cancer Burden;Cancer Center;Cancer Control;Cancer Control Research;cancer health disparity;Cancer Survivor;career;Caring;Censuses;Collaborations;Communities;community advisory board;community collaboration;community partners;Data;Data Analyses;Development;efficacious intervention;Eligibility Determination;Ensure;Environment;Evaluation;experience;falls;Food Access;Funding;Goals;graduate student;Health;Health Services Accessibility;Human Resources;improved;Inequity;Institution;Institutional Review Boards;Intervention;Life;Literature;Malignant Neoplasms;member;Methodology;Mission;National Cancer Advisory Board;National Cancer Institute;Outcome;Peer Review;Phase;Pilot Projects;Postdoctoral Fellow;Poverty;Poverty Areas;Prevention;Process;programs;Research;Research Methodology;Research Personnel;Research Project Grants;Resources;Risk Factors;Rural;social;social health determinants;survivorship;synergism;therapy development;Training;Transportation;Universities;University of Alabama at Birmingham Cancer Center

PROJECT_TITLE: Development Core-003


ADMINISTERING_IC: DK

ED_INST_TYPE: PRIMATE CENTERS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Cardiovascular;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Diabetes;Emerging Infectious Diseases;Immunization;Infectious Diseases;Lung;Nutrition;Obesity;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID;Prevention;Vaccine Related

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Narrative Pre-existing conditions such as diabetes, heart disease, and high blood pressure, which share underlying obesity, increase the severity of COVID-19. Conversely, patients with COVID-19 often present with newly- diagnosed diabetes, or develop diabetes and other aspects of metabolic disease after recovering from COVID- 19. This project will investigate this two-way relationship between COVID-19 and obesity using a nonhuman primate model, since the nonhuman primate response to the SARS-CoV-2 coronavirus and to obesity is similar to humans.

PI_NAMEs: KIEVIT, PAUL ;ROBERTS, CHARLES T (contact);SLIFKA, MARK K;STREBLOW, DANIEL N

PROGRAM_OFFICER_NAME: LYNCH, CHRISTOPHER

PROJECT_TERMS: 2019-nCoV;Acceleration;Acute;acute COVID-19;Acute Disease;acute infection;Address;Adipocytes;Adipose tissue;Adult;adverse outcome;Affect;Alveolar;Anatomy;Animals;Antigens;Appearance;Autopsy;Biological Markers;Blood;blood glucose regulation;C-Peptide;Cardiovascular Diseases;Cells;Chronic;Clinical;clinical care;clinical diagnosis;clinical heterogeneity;comorbidity;Coronavirus;COVID-19;COVID-19 impact;COVID-19 pandemic;COVID-19 patient;COVID-19 risk;COVID-19 severity;COVID-19 survivors;cytokine;Data;Diabetes Mellitus;diet-induced obesity;Disease;Endocrine;Endothelial Cells;endothelial dysfunction;Exhibits;fasting glucose;Foundations;Glucose;glucose metabolism;glucose tolerance;glycemic control;Glycosylated hemoglobin A;Heart Diseases;Hospitalization;Human;human tissue;Hyperinsulinism;Hypertension;Immune;Immune response;Immunohistochemistry;Impairment;Individual;Infection;Inflammation;Insulin;Insulin Resistance;insulin secretion;islet;Lavage;Light;Link;lipid metabolism;Lipids;Lung;Macaca;Macaca mulatta;Macrophage;male;Metabolic;Metabolic Control;Metabolic Diseases;metabolic phenotype;Metabolism;Modeling;Monitor;Morbidity - disease rate;Morphology;mortality;nasal swab;Nature;Newly Diagnosed;nonhuman primate;novel;Nucleic Acids;obese person;Obesity;Oral;Outcome;Pancreas;pandemic disease;Pathology;patient population;Patients;Peripheral;Phase;Post-Acute Sequelae of SARS-CoV-2 Infection;pre-clinical;Pre-Clinical Model;Predisposition;Public Health;Pulmonary Pathology;Quantitative Reverse Transcriptase PCR;Recovery;Reporting;Resistance;Respiratory Disease;Respiratory physiology;response;Risk;Risk Factors;Sampling;SARS-CoV-2 B.1.617.2;SARS-CoV-2 infection;SARS-CoV-2 variant;Serology;severe COVID-19;Severities;Severity of illness;subcutaneous;System;Testing;Therapeutic;therapy development;Thinness;Time;Tissue Sample;Tissues;vaccination outcome;Vaccines;variants of concern;Viral;Viral Antigens;Viral Load result;Viral reservoir;Viremia;Virus Latency;Visceral;western diet

PROJECT_TITLE: Impact of obesity on SARS-CoV-2 infection and reciprocal effects of SARS-CoV-2 on metabolic disease


NIH_SPENDING_CATS: Endocrine Disruptors;Foodborne Illness;Health Effects of Indoor Air Pollution

PHR: PROJECT NARRATIVE – PROJECT 4 DETECTION Per- and polyfluoroalkyl substances (PFAS) have become the most high-profile pollutants in the US, based on the detection of thousands of contaminated sites, the discovery of PFAS in public water supplies serving millions of Americans, and their highly persistent, toxic and bioaccumulative nature, resulting in food chain contamination worldwide. P4–Detection proposes (i) the development and design of simple yet effective materials for remediating PFAS-contaminated groundwater plumes and in situ monitoring of field trials of ex situ treatment approaches on Cape Cod using passive samplers from STEEP I; (ii) further development and field application of passive samplers as screening tools for legacy and novel PFAS in the Delaware River region with a focus on their bioaccumulation; and (iii) characterizing complementary air sampling tools for stakeholder needs to assess the importance of PFAS inhalation as an exposure pathway. P4-Detection will continue to work with federal (EPA ORD) and state stakeholders (DE, RI) to advance the use of passive samplers in characterizing bioaccumulation and biotransformation of legacy, novel, and total PFAS by aquatic biota, and to rely on passive samplers to assess the atmospheric transport of PFAS away from PFAS.

PROJECT_TERMS: Address;Air;air sampler;air sampling;American;aqueous;Arctic Regions;Atmosphere;Binding;bioaccumulation;Biological Availability;Biota;Cellular Assay;Chemicals;Chemistry;Child;Cods;Collaborations;Consumption;cost effective;Data;Delaware;design;Detection;Development;drinking water;Dust;Effectiveness;Embryo;Environment;Environmental Exposure;environmental transport;Excision;exposed human population;exposure pathway;Exposure to;Faeroe Islands;FAIR principles;Fellowship;Fiber;field study;Film;Fishes;Food Analysis;food chain contamination;Gases;Goals;ground water;Hazardous Substances;Health;Household;Human;In Situ;indoor air;indoor dust;Inhalation;innovation;Joints;Knowledge;Laboratories;Laboratory Study;Link;Malignant Neoplasms;Measures;Medial;Metabolic;Metabolic Biotransformation;Methods;Monitor;Nature;novel;Participant;particle;Performance;Periodicity;Phase;Policies;pollutant;Poly-fluoroalkyl substances;polyacrylate;Polyethylenes;Polymers;Production;Proxy;remediation;Research;Research Project Grants;Resistance;Rodent Model;Sampling;screening;Screening procedure;Seafood;Serum;Shellfish;Signal Recognition Particle;Site;Source;Statistical Data Interpretation;success;Technology;Time;Tissues;tool;Toxic effect;Translational Research;uptake;US State;Validation;Water;Water Supply;Work

PROJECT_TITLE: Passive samplers in support of Remediation, Detection and Bioaccumulation of PFAS


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Prevention;Social Determinants of Health

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: NARRATIVE Older adults who encounter adverse interpersonal experiences (AIEs) in their social environment, such as loneliness, typically have higher risk for Mild Cognitive Impairment (MCI) and Alzheimer’s Disease and Related Dementias (ADRD). This project examines the significance of AIEs for diminished cognitive functioning in later life by conducting a follow-up of the Minnesota-Carolina Twin Study of Aging (MCTSA), a longitudinal study of 800 pairs of ethnically diverse twins. The twin design of the study allows a strong test of the hypothesis that AIEs are linked to diminished cognitive functioning and Mild Cognitive Impairment (MCI) with downstream implications for Alzheimer’s Disease and Related Dementias (ADRD) risk through environmental pathways.

PI_NAMEs: KRUEGER, ROBERT F (contact);ROISMAN, GLENN I

PROGRAM_OFFICER_NAME: KING, JONATHAN W

PROJECT_TERMS: Address;Adult;Affect;African American;Age;age related decline;Age-associated memory impairment;Aged, 80 and over;Aging;aging population;Alzheimer's disease diagnosis;Alzheimer's disease related dementia;Alzheimer's disease risk;American;Biological Process;care costs;Cognition;Cognitive;Cognitive aging;cognitive function;Conflict (Psychology);cost;Data;Dementia;dementia risk;design;Development;diaries;Disease;Early identification;economic cost;Education;Environment;ethnic diversity;European;expectation;experience;Family;Family member;follow-up;Follow-Up Studies;Friends;Genetic;Geography;Grant;Growth;Health;Heritability;high risk;Impaired cognition;improved;Individual;Individual Differences;Intervention;late life;Life Expectancy;Light;Link;Loneliness;Longevity;Longitudinal Studies;Measures;Mediating;Methods;mild cognitive impairment;Minnesota;Modeling;novel;older adult;Outcome;Participant;Pathway interactions;Pattern;Persons;Population;Prevention;Process;psychologic;psychosocial;Public Health;Research;Risk;Same-sex;Science;social;Social Environment;Social isolation;success;Testing;Twin Multiple Birth;Twin Studies;United States;Variant;Work

PROJECT_TITLE: The impact of adverse interpersonal experiences (AIE) on mild cognitive impairment (MCI) and risk for Alzheimer's disease and related dementias (ADRD) in ethnically diverse twins

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-RPHB-J(02)]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alcoholism, Alcohol Use and Health;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Prevention;Rehabilitation;Substance Misuse;Women's Health Research

ORG_DEPT: PSYCHIATRY

PHR: NARRATIVE The aging of America together with escalating age-related cognitive decline and increasing alcohol drinking in older men and women signals an urgency to investigate the role of alcohol use in exacerbating cognitive decline toward dementia and postural instability as risk for falls attendant morbidity and mortality. Outcomes of this research have the potential to confirm alcohol consumption as a modifiable risk factor for dementia and for standing and walking instability, thereby providing justification for implementing balance, cognitive, and alcohol assessment in treatment settings and for creating protective strategies to enhance postural stability in standing and walking.

PI_NAMEs: SULLIVAN, EDITH VIONI (contact);ZAHR, NATALIE M

PROGRAM_OFFICER_NAME: GRAKALIC, IVANA

PROJECT_TERMS: Acceleration;Activities of Daily Living;Affect;Age;Age-associated memory impairment;Aging;Alcohol consumption;alcohol measurement;Alcohols;Ataxia;Award;Awareness;Behavioral;Biological Markers;Brain;causal model;Cerebellopontine;Cognitive;cognitive control;Cognitive deficits;cognitive performance;Complex;Data;deep learning;Dementia;dementia risk;design;drinking;Equilibrium;fall risk;falls;follow-up;functional decline;Gait;Gait abnormality;Gait speed;Harm Reduction;hazardous drinking;Hematology;Impaired cognition;Individual;longitudinal analysis;Measures;Mediating;Memory;men;mild cognitive impairment;modifiable risk;Morbidity - disease rate;mortality;Motor;Motor Cortex;motor deficit;nutrition;Nutritional;older men;older women;Outcomes Research;Parietal;Physiological;Pontine structure;Population;Posture;posture instability;potential biomarker;Predictive Factor;Quality of life;Recording of previous events;response;Risk Factors;Role;Sensory;Sensory Physiology;sensory system;sex;Signal Transduction;Statistical Models;Testing;Walking;Woman;Work

PROJECT_TITLE: Alcohol: A Modifiable Risk Factor for Ataxia and Decline in MCI


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Biomedical Imaging;Bipolar Disorder;Brain Disorders;Cannabinoid Research;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Mental Health;Mental Illness;Neurosciences;Prevention;Serious Mental Illness;Substance Misuse

ORG_CITY: CHARLESTON

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: Project Narrative This pharmaco-neuroimaging investigation will evaluate the therapeutic potential of a medication that has been demonstrated to increase cortical gamma-Aminobutyric Acid (GABA) (i.e., gabapentin) concentrations in individuals with epilepsy, in a difficult-to-treat population characterized by unique GABAergic and glutamatergic deficits: individuals with co-occurring bipolar disorder and cannabis use disorder.

PI_NAMEs: PRISCIANDARO, JAMES JOSEPH (contact)

PROGRAM_OFFICER_NAME: FEDOTA, JOHN RAPHAEL

PROJECT_TERMS: Adherence;Adjuvant Analgesic;Adjuvant Study;Adjuvant Therapy;Animals;Anterior;Anti-Anxiety Agents;anti-depressive agents;Anxiety;Anxiety Disorders;anxiety symptoms;attentional control;Automobile Driving;Basal Ganglia;behavioral response;Bipolar Disorder;Brain;Brain region;Cannabis;cannabis craving;cannabis cue;Characteristics;Cigarette Smoker;cigarette smoking;cingulate cortex;Clinical;Corpus striatum structure;cost;craving;cue reactivity;Dangerousness;depressive symptoms;Diagnosis;disability;Dorsal;Dose;Double-Blind Method;efficacy trial;Enrollment;Epilepsy;Equilibrium;Failure;FDA approved;Functional disorder;Functional Magnetic Resonance Imaging;Funding;gabapentin;gamma-Aminobutyric Acid;General Population;Glutamates;Homeostasis;Hospitalization;Human;Impairment;improved;Individual;Intervention;Investigation;Literature;Magnetic Resonance Imaging;Magnetic Resonance Spectroscopy;Manic;marijuana use;marijuana use disorder;mood symptom;Moods;multimodal neuroimaging;National Institute of Drug Abuse;Nervous System Disorder;neuroimaging;optimal treatments;Outcome;Participant;Pharmaceutical Preparations;pharmacologic;Placebo Control;Placebos;Population;Prevalence;Protons;Randomized;Randomized, Controlled Trials;recruit;Reporting;Research Design;Residual state;response;Safety;Sample Size;Sampling;Sleep;Sleep Disorders;Smoker;Smoking Status;Stimulus;Suicide;suicide rate;symptomatology;Symptoms;Therapeutic;treatment group;United States National Institutes of Health;Visual

PROJECT_TITLE: Gabapentin for Restoring GABA/glutamate Homeostasis in Co-occurring Bipolar and Cannabis Use Disorders: A Randomized, Double-blind, Placebo-controlled, Parallel-group, Clinical MRI Study

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


NIH_SPENDING_CATS: Endocrine Disruptors

PHR: PROJECT NARRATIVE – ADMINISTRATIVE CORE (AC) Since 2015, when the first STEEP Center proposal was submitted, the universe of poly- and perfluorinated alkyl substances (PFAS) has substantially expanded, many have been recognized as major pollutants threatening public health across the U.S, and new adverse health effects have emerged, thus provoking a need to reconsider current guidelines for maximum concentration levels or exposure limits. The continuation of the proposed STEEP II SRP Center will characterize PFAS exposures and health risks, and address the evolving needs of communities affected by PFAS-contaminated drinking water, whether past or present, or by other sources of PFAS exposure, including contamination of the food web (fish/shellfish), consumer products, air, soil, and dust. Maintaining and accelerating STEEP’s focus on innovation and collaboration remains the AC’s primary goal, and its team will build on the success already achieved by STEEP I in regard to the forefront of PFAS science, the inspiration and training of the next generation of PFAS scientists, and supporting equitable community engagement, comprehensive research translation, and inclusive outreach.

PROJECT_TERMS: Acceleration;Address;Advisory Committees;Affect;Air;Assistantship;Awareness;bioaccumulation;Breathing;Chemicals;Cods;Collaborations;Communication;Communication Tools;Communities;community engagement;Compensation;Complement;Complex;consumer product;contaminated drinking water;Country;COVID-19 severity;Data;data management;data sharing;Dedications;design;Detection;Development;Diamond;Doctor of Medicine;Doctor of Philosophy;drinking water;Dust;Educational process of instructing;Educational workshop;Ensure;Environment;Environmental Exposure;Epidemiologist;Equipment;Equity;equity, diversity, and inclusion;Evaluation;experience;Exposure to;Faeroe Islands;Feedback;Fishes;Food Contamination;Food Webs;Fostering;Funding;Funding Agency;General Population;Goals;graduate school;graduate student;ground water;Grouping;Guidelines;Health;Human;Human Resources;Immune System Diseases;immunotoxicity;innovation;insight;Institution;Interdisciplinary Study;interest;International;Internet;Joints;Journalism;Knowledge;Leadership;meetings;Mentors;Metabolic;Minority Graduate Student;Mission;Monitor;National Institute of Environmental Health Sciences;next generation;novel;operation;outreach;podcast;Policies;policy recommendation;pollutant;Poly-fluoroalkyl substances;Privatization;product development;programs;Public Health;Publications;Reporting;Research;Research Personnel;Resources;Rhode Island;Risk;Risk Assessment;Role;Schools;Science;Scientist;Services;Shellfish;Site;skills;social;social media;Soil;Source;Students;success;Suggestion;Superfund;symposium;technical report;technique development;Technology Transfer;Testing;tool;Training;Training Programs;Translational Research;Universities;Update;video chat;Water;web site;webinar;Work

PROJECT_TITLE: Administration Core


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Brain Disorders;Clinical Research;Multiple Sclerosis;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: SAN FRANCISCO

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Myelin oligodendrocyte glycoprotein (MOG) antibody-associated disease (MOGAD) was recently recognized as a spectrum of central nervous system inflammatory conditions that are separate from multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD). Research indicates that MOG-specific T cells have a central role in the pathogenesis of MOGAD, yet there is essentially no knowledge regarding MOG-specific T cells in MOGAD. The goal of this project is to identify and characterize MOG-specific T cells in MOGAD, and by using a model of MOGAD, to determine how MOG-specific T cells and B cells cooperate to cause MOGAD.

PI_NAMEs: ZAMVIL, SCOTT S (contact)

PROGRAM_OFFICER_NAME: GUERAU, MIREIA

PROJECT_TERMS: Acute Disseminated Encephalomyelitis;Amino Acid Sequence;Antibodies;Antibody Response;aquaporin 4;Autoantigens;Autoimmune;Autoimmune Diseases;Autoimmunity;B-Cell Antigen Receptor;B-Lymphocytes;Bilateral;CD8B1 gene;Cells;Central Nervous System;central nervous system injury;CNS autoimmunity;Collaborations;Demyelinating Diseases;Development;Diagnosis;Disease;disease phenotype;Encephalomyelitis;Event;Experimental Autoimmune Encephalomyelitis;FDA approved;Genomics;Goals;Human;humoral immunity deficiency;IgG1;Immune response;Immunize;Immunoglobulin-Secreting Cells;in vivo;Individual;Inflammation;Inflammatory;insight;Institution;Knock-in Mouse;Knowledge;Length;Mediating;Memory;MHC Class II Genes;Modeling;mouse myelin oligodendrocyte glycoprotein;Multiple Sclerosis;Mus;Myelogenous;Nervous System Disorder;Neurologic;Neuromyelitis Optica;novel;oligodendrocyte-myelin glycoprotein;Optic Neuritis;Organ;participant enrollment;Pathogenesis;Pathogenicity;Pathologic;Patients;Peptides;Peripheral Blood Mononuclear Cell;Phenotype;Predisposition;programs;Proteins;recruit;Recurrence;Research;response;Role;seropositive;Serum;Shapes;single cell analysis;single-cell RNA sequencing;Source;Specificity;T cell response;T-Cell Receptor;T-Lymphocyte;T-Lymphocyte Epitopes;Technology;Testing;Translating;Transverse Myelitis;water channel

PROJECT_TITLE: Characterization of T cells in MOG antibody-associated disease

STUDY_SECTION: HAI

STUDY_SECTION_NAME: Hypersensitivity, Autoimmune, and Immune-mediated Diseases Study Section[HAI]


NIH_SPENDING_CATS: Data Science;Endocrine Disruptors;Networking and Information Technology R&D (NITRD)

PHR: PROJECT NARRATIVE – DATA MANAGEMENT AND ANALYSIS CORE (DMAC) DMAC is an essential component of the proposed STEEP II SRP renewal, providing data management, biostatistical, and data science support and ensuring resource sharing for all four of STEEP’s research projects. This DMAC proposal is expressly relevant to the NIEHS mission because it implements Findability, Accessibility, Interoperability, Reuse (FAIR) principles, quality assurance and quality control (QA/QC), and state-of-the-art statistical methods to determine how PFAS exposures impact health outcomes. DMAC will ultimately provide a data management example of a user-friendly, low-cost, and FAIR compliant infrastructure, as well as reproducible and precise empirical results.

PI_NAMEs: DEKKER, HARRISON  (contact)

PROJECT_TERMS: Address;Adopted;Bayesian Modeling;Biometry;Code;Collaborations;Communication;Communities;community engagement;complex data;Computing Methodologies;computing resources;cost;Data;Data Analyses;Data Analytics;data exploration;data integration;data interoperability;data management;data quality;data repository;data reuse;Data Science;data science infrastructure;data sharing;data sharing networks;data visualization;design;Development;Discipline;Disease;Documentation;Ensure;Environmental Health;experience;FAIR principles;Feedback;flexibility;Goals;Growth;Health;High Performance Computing;improved;Information Storage;Infrastructure;innovation;Life Cycle Stages;Link;Machine Learning;Mass Spectrum Analysis;Mathematics;member;Metadata;method development;Methodology;Methods;Mission;Modeling;Modernization;Monitor;National Institute of Environmental Health Sciences;open data;Outcome;Policy Maker;Poly-fluoroalkyl substances;power analysis;Preparation;Procedures;Process;Protocols documentation;quality assurance;Quality Control;repository;Reproducibility;Research;Research Design;Research Personnel;Research Project Grants;Resource Sharing;Resources;Running;Science;Series;Signal Recognition Particle;skills;sound;Source;Statistical Data Interpretation;Statistical Methods;statistics;Structure;Time;tool;Training;Universities;user-friendly;Work

PROJECT_TITLE: Data Management and Analysis Core (DMAC)


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences

ORG_NAME: HARVARD UNIVERSITY

PHR: Project Narrative Threat-coping behaviors evolve over time, as humans and animals initially avoid and eventually learn to overcome potential threats. Abnormality in such dynamic adjustment is thought to underlie various psychiatric disorders such as post-traumatic stress disorder and anxiety disorders. The result of the proposed study will identify novel neural circuits that critically regulate such dynamic adjustment in threat-coping, and thus will provide crucial insights into these psychiatric disorders.

PI_NAMEs: UCHIDA, NAOSHIGE  (contact);WATABE-UCHIDA, MITSUKO

PROGRAM_OFFICER_NAME: VICENTIC, ALEKSANDRA

PROJECT_TERMS: Acute;Animals;Anxiety Disorders;Area;auditory thalamus;avoidance behavior;Basal Ganglia;Behavior;Behavior Control;Behavioral;Brain Stem;Cell Nucleus;Characteristics;coping;Coping Behavior;Corpus striatum structure;Dopamine;dopaminergic neuron;Equilibrium;Event;Exhibits;experience;Fiber;Future;Globus Pallidus;Goals;Human;Impairment;insight;Label;Lateral;Lateral Geniculate Body;Learning;Lesion;Mental disorders;molecular marker;Monitor;Motivation;Movement;Mus;neural circuit;neuromechanism;Neurons;novel;optogenetics;Output;Parvalbumins;Pathway interactions;Phase;Photometry;Play;Post-Traumatic Stress Disorders;Process;response;Rewards;Role;Sensory;Signal Transduction;Stimulus;Substantia nigra structure;Tail;Testing;Thalamic structure;Time;Visual;Withdrawal

PROJECT_TITLE: Basal ganglia circuit mechanisms for threat coping

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


NIH_SPENDING_CATS: American Indian or Alaska Native;Clinical Research;Foodborne Illness;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

PHR: PROJECT NARRATIVE – COMMUNITY ENGAGEMENT CORE (CEC) The Community Engagement Core (CEC) will address community concerns on Cape Cod, Massachusetts, about per- and polyfluoroalkyl substances (PFAS), with a goal of identifying local sources of PFAS exposures and developing intervention strategies to reduce these exposures and prevent adverse health outcomes. CEC will foster bidirectional partnerships with local water and health officials, members of the Mashpee Wampanoag Tribe, high school teachers and students, environmental nonprofit organizations, and other concerned residents through focus groups, community events, a community advisory committee, and resident participation in the design and implementation of a sampling program for local foods. CEC will advance public health by potentially reducing exposures to PFAS from the local environment, by providing new information about sources of PFAS exposure, and by supporting decision making by local, state, and federal water and health agencies.

PI_NAMEs: SCHAIDER, LAUREL A. (contact)

PROJECT_TERMS: Academy;Address;Affect;aqueous;Area;Awareness;base;Cods;Collaborations;Communication;Communities;community advisory board;community center;community collaboration;community empowerment;community engagement;community organizations;community partners;Consumption;contaminated drinking water;contaminated water;County;Decision Making;design;drinking water;Educational Curriculum;effectiveness evaluation;empowerment;Environment;Environmental Exposure;Environmental Pollution;Event;experience;exposure pathway;Exposure to;Feedback;Film;Fire - disasters;Fishes;Focus Groups;Food;Fostering;Goals;ground water;Guidelines;Health;high school;High School Faculty;Home;Household;innovation;interest;Intervention;Interview;Learning;Location;Malignant Breast Neoplasm;Massachusetts;member;Military Personnel;Municipalities;Nonprofit Organizations;novel;Outcome;Participant;Patient Recruitments;pollutant;Poly-fluoroalkyl substances;prevent;Privatization;Process;programs;Public Health;Research;Resources;Risk;risk perception;Risk Reduction;Sampling;septic;Shellfish;Source;source localization;Students;Surface;symposium;System;Testing;Training;Translational Research;tribal lands;tribal member;Tribes;Update;Wampanoag;Water;Water consumption;water quality;Water Supply;well water;Work

PROJECT_TITLE: Community Engagement Core


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: Project Narrative Toxocariasis is the most common zoonotic helminth infection in the United States (US) and represents one of our nation’s most important contributors to childhood health disparities. Despite its enormous health and socioeconomic importance, toxocariasis remains underdiagnosed in the US due to limited access to and poor test performance of commercially available diagnostic tests. This study will produce an innovative Toxocara diagnostic assay with improved accessibility and test performance in order to guide public health interventions to prevent Toxocara-induced morbidity in US children.

PI_NAMEs: WEATHERHEAD, JILL ELIZABETH (contact);ZHAN, BIN

PROGRAM_OFFICER_NAME: PESCE, JOHN T

PROJECT_TERMS: accurate diagnosis;Achievement;Acute;Affect;Aftercare;Albendazole;Anthelmintics;Antibodies;Antigens;Asthma;Biological Assay;Black race;Blindness;C-Type Lectins;Canis familiaris;cDNA Library;Characteristics;Child;Child Health;Childhood;Chronic Disease;Clinical;cost;Development;Diagnosis;Diagnostic;diagnostic assay;Diagnostic tests;Disease;Enzyme Immunoassay;Enzyme-Linked Immunosorbent Assay;eosinophil;Eosinophilia;Epilepsy;Evaluation;Exposure to;Felis catus;Generations;health disparity;health economics;Health Resources;helminth infection;Helminths;High Prevalence;Homologous Gene;Human;Immune response;Immunoassay;Immunodominant Antigens;Immunoglobulin G;improved;innovation;Laboratories;Larva;Larva Migrans;Longitudinal cohort;Measures;Monitor;Morbidity - disease rate;Nematoda;Not Hispanic or Latino;novel;Performance;performance tests;Peripheral;Persons;Poverty;prevent;public health intervention;Recombinant Proteins;Recombinants;Reproducibility;Research;response;Seroprevalences;socioeconomics;Specificity;standard of care;Surveys;Syndrome;Technology;Time;Toxocara;Toxocara canis;Toxocariasis;treatment response;underserved community;United States;Western Blotting;Zoonoses

PROJECT_TITLE: Novel recombinant protein immunoassays for the diagnosis and monitoring of toxocariasis in children living in the United States.

STUDY_SECTION: EDIT

STUDY_SECTION_NAME: Etiology, Diagnostic, Intervention and Treatment of Infectious Diseases Study Section[EDIT]


PHR: PROJECT NARRATIVE – RESEARCH EXPERIENCE AND TRAINING COORDINATION CORE (RETCC) The University of Rhode Island (URI)-led STEEP (Sources, Transport, Exposure and Effects of PFAS) Center will provide solutions to the NIH Superfund Research Program (SRP) in addressing emerging per- and polyfluorinated alkyl substances (PFAS) for reducing human exposure, providing training, and engaging affected communities. In response to the SRP mandate, the STEEP Research Experience and Training Coordination Core (RETCC) will provide trainees (pre- and post-doctoral) with resources and opportunities to become skilled scientists/engineers, equipped to address various aspects of emerging contaminants, specifically the scientific, remediation, community, and translational facets of PFAS, through research experiences and community engagement. Beyond their individual research projects, all STEEP II trainees will participate in joint laboratory meetings, laboratory rotations, the PFAS Scholars seminar series, an annual trainee retreat, and a new “Action Team” initiative where trainees will work with STEEP PIs, the Administrative Core (AC) and Community Engagement Core (CEC), on applied aspects of their research through education, outreach, or policy.

PROJECT_TERMS: Address;Affect;Area;Benchmarking;Biometry;career;career development;Chemistry;Communication;Communities;community collaboration;community engagement;Community Outreach;Competence;Complement;computer science;Data Science;Dedications;Detection;detection method;Economics;Education;Educational Curriculum;empowerment;Engineering;Ensure;Environment;Environmental Health;Environmental Pollution;Environmental Protection;Epidemiology;experience;exposed human population;Exposure to;Faculty;Fellowship;Funding;Goals;Government regulations;graduate school;graduate student;Grant;Hazardous Substances;Hazardous Waste;Health;Health protection;high school;Human;improved;Individual;Industrialization;Infrastructure;innovation;Institution;International;Joints;Knowledge;Laboratories;Leadership;Learning;learning strategy;lectures;meetings;Mentors;Mentorship;Minority;Nature;next generation;novel;occupational health/safety;Oceanography;Online Systems;operation;Oral;outreach;pedagogy;Pharmacy facility;Policies;Poly-fluoroalkyl substances;Postdoctoral Fellow;pre-doctoral;Program Research Project Grants;programs;Public Health;Public Health Practice;Public Policy;Published Comment;Regulation;remediation;Research;Research Activity;Research Personnel;Research Project Grants;Resource Development;Resources;response;responsible research conduct;Rhode Island;Risk;Risk Assessment;Rotation;Safety;Schools;Science;Science Policy;Scientific Inquiry;Scientist;Series;Site;skills;social;Source;Students;Superfund;Techniques;Toxicant exposure;Training;Training Activity;Training Programs;Translating;Translational Research;Underrepresented Populations;Underrepresented Students;United States National Institutes of Health;Universities;Woman;Work;Writing


ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

PHR: NARRATIVE The long-term goal of this proposal is to develop new novel therapies to decrease venous neointimal hyperplasia (VNH) and subsequent venous stenosis (VS) after angioplasty of stenotic hemodialysis arteriovenous fistulae (AVFs). End-stage kidney disease affects >4M patients globally. A well-functioning vascular access using an AVF is required for renal replacement therapy using hemodialysis, however, 60% of AVFs require PTA to maintain vascular patency and these fail due to the development of recurrent VS caused by VNH.

PI_NAMEs: MISRA, SANJAY  (contact)

PROGRAM_OFFICER_NAME: ABBOTT, KEVIN C

PROJECT_TERMS: Affect;American;Angioplasty;Animals;Arteries;Arteriovenous fistula;Balloon Angioplasty;Binding;Blood flow;Blood Vessels;CCL2 gene;CCL7 gene;CCL8 gene;Cd68;Cell Adhesion Molecules;Cells;chemokine receptor;Chemotaxis;Clinical;comparison control;cost;cytokine;Data;Development;Devices;Diagnosis;Disease Outcome;Doppler Ultrasound;Drug Kinetics;drug release kinetics;Electron Microscope;Encapsulated;End stage renal failure;Endothelial Cells;Endothelium;experimental study;Family suidae;fatty acid-binding proteins;Fibrosis;Functional disorder;Gene Expression;Genes;Glycolates;Goals;Hemodialysis;Histologic;Hydrogels;Hyperplasia;Immune;immune cell infiltrate;improved;In Vitro;Individual;Infiltration;Inflammation;Inflammatory;inhibitor;injured;innovation;Intercellular adhesion molecule 1;Interleukin-8;Kidney Diseases;Legal patent;Letters;Leukocytes;light scattering;Liposomes;Liquid Chromatography;loss of function;Macrophage;Messenger RNA;migration;Modulus;Molecular;Molecular Chaperones;monocyte;monocyte chemoattractant protein 1 receptor;Monocyte Chemoattractant Proteins;mortality;mouse model;nanoparticle;neutralizing antibody;novel therapeutics;Oral;Paclitaxel;Patients;PECAM1 gene;Pharmaceutical Preparations;Phase I Clinical Trials;Pluronics;Procedures;Proliferating;protein expression;Proteins;Recommendation;recruit;Recurrence;Renal Replacement Therapy;restenosis;Risk;Role;Safety;Scanning;small molecule inhibitor;Smooth Muscle Myocytes;Stenosis;T cell infiltration;tandem mass spectrometry;Testing;Time;Tunica Adventitia;ultrasound;vascular injury;Vascular Patency;Vascular remodeling;Veins;Venous

PROJECT_TITLE: Monocyte chemoattractant Proteins and Vascular Injury

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Rural Health;Social Determinants of Health

ORG_CITY: LEBANON

ORG_NAME: DARTMOUTH-HITCHCOCK CLINIC

PHR: Project Narrative Although 20% of Americans live in rural communities, there are significant gaps in our understanding of rural cancer care disparities, the influence of community-level social determinants of health, and efficacy of policy solutions to improve equity of cancer care delivery. Utilizing multilevel modelling, geocomputational and spatiotemporal approaches, and econometric methodology, this research will determine the extent to which rurality and community-level socioeconomic deprivation influence disparities in cancer care delivery and how they interact with other social determinants of cancer care, including insurance coverage. Further, the project will assess the degree to which health insurance expansion influences care delivery across rural and socioeconomically strained communities.

PI_NAMEs: LOEHRER, ANDREW PHILLIP (contact)

PROGRAM_OFFICER_NAME: BIAN, YANSONG

PROJECT_TERMS: Address;Affect;Affordable Care Act;American;Area;Award;cancer care;cancer health disparity;cancer therapy;care delivery;career;career development;Caring;Categories;Characteristics;clinical practice;Cohort Studies;Communities;Complex;deprivation;Diagnosis;Disease;Disparity;disparity reduction;dissemination strategy;Early Diagnosis;Econometric Models;econometrics;economic disparity;Education;Employment;Equity;Excision;federal policy;Follow-Up Studies;Foundations;Funding;Geographic Locations;Geography;Goals;health determinants;Health Insurance;Health Policy;Health Services;Health Services Accessibility;Health Services Research;Housing;improved;Income;Individual;innovation;Insurance;Insurance Coverage;intersectionality;Knowledge;Lead;Leadership;Link;Location;Malignant neoplasm of liver;Malignant Neoplasms;Measures;Medicaid;Medical center;Mentors;Methodology;Methods;Modeling;multilevel analysis;neoplasm registry;novel;Operative Surgical Procedures;optimal treatments;Organ;Outcome;Patient Care;Patients;Policies;Policy Analysis;Policy Maker;population based;Poverty;Predisposition;Probability;Quasi-experiment;Race;Research;Research Personnel;Resources;Rural;rural cancer care;Rural Community;rural patients;rural residence;rurality;Skin;social determinants;social health determinants;Socioeconomic Factors;socioeconomics;soft tissue;Solid;spatiotemporal;Stage at Diagnosis;Surgical Oncologist;Techniques;Time;Training;Urban Population;Visualization;vulnerable community;Vulnerable Populations;waiver

PROJECT_TITLE: Geospatial drivers of cancer care disparities and their susceptibility to health policy changes

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Bioengineering;Infectious Diseases;Lung;Rare Diseases

ORG_CITY: DAVIS

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Narrative The cells lining the lung form a protective layer that acts as both a barrier and an alarm system for infections. During some respiratory infections, including COVID-19, this alarm system responds inappropriately, leading to lung inflammation and an often-fatal condition known as Acute Lung Injury/Acute Respiratory Distress Syndrome (ALI/ARDS). In this project, we will develop a new technology for tracking the alarm response in real-time, which will enable us to identify the best drugs to regain control of the signals and treat respiratory inflammation in multiple types of infection.

PI_NAMEs: ALBECK, JOHN G. (contact)

PROGRAM_OFFICER_NAME: SHENOY, SIDDHARTH KAUP

PROJECT_TERMS: Accounting;Acute Lung Injury;Acute Respiratory Distress Syndrome;Airway Disease;airway epithelium;airway inflammation;Alveolar;Benchmarking;biological adaptation to stress;Biological Models;Caring;cell behavior;cell growth;Cell Line;Cell Physiology;Cell secretion;Cell Signaling Process;cell type;Cells;Cellular biology;Chronic Obstructive Pulmonary Disease;Communication;Complement;Complex;Computer Models;COVID-19;cytokine;Cytokine Signaling;data mining;data-driven model;Disease;drug efficacy;Epithelial Cells;Epithelium;Event;Failure;Fibrosis;FRAP1 gene;Homeostasis;Image;Immune;Immune response;Immunofluorescence Immunologic;improved;Individual;Infection;Infectious Agent;Inflammation;Inflammatory;inflammatory milieu;Inflammatory Response;Intervention;kinase inhibitor;Link;live cell imaging;Lung;Lung Diseases;Malignant neoplasm of lung;Malignant Neoplasms;MAP Kinase Gene;MAPK8 gene;Maps;Measurement;Metabolic;Methodology;Methods;Modeling;Modernization;mortality;multidisciplinary;new technology;NF-kappa B;novel therapeutic intervention;Output;p38 Mitogen Activated Protein Kinase;Paracrine Communication;Pathway interactions;Pattern;Periodicals;Periodicity;Pharmaceutical Preparations;pharmacologic;Phase;Phosphotransferases;Play;Population;Process;Production;programs;Proto-Oncogene Proteins c-akt;Pulmonary Inflammation;Resolution;Respiratory Tract Infections;response;restraint;Role;Route;sensor;Sentinel;Signal Pathway;Signal Transduction;Source;spatial relationship;Specific qualifier value;stem;Structure;Syndrome;System;Technology;technology platform;Time;tissue fixing;Tissues;tool;transcription factor;Variant;Work

PROJECT_TITLE: Decoding temporal epithelial signaling programs to restore homeostasis in acute lung injury

STUDY_SECTION: CMT

STUDY_SECTION_NAME: Cellular and Molecular Technologies Study Section[CMT]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Sexually Transmitted Infections

ORG_CITY: PROVIDENCE

ORG_NAME: BROWN UNIVERSITY

PHR: The Emerging Infectious Disease and HIV Scholars at Brown University program is a collaboration between the Alpert Medical School of Brown University, the affiliated hospitals, and the Rhode Island Department of Health. The program seeks to develop a physician- scientist workforce focused on clinical research to inform practical responses to HIV and associated infections the important role of clinical research, particularly among marginalized communities, to help end the HIV epidemic. This program is committed to training scholars during medical school, including a Masters of Science and a mentored clinical research project. Scholars will be inspired, trained, and supported as “microbe hunters” to respond to the various challenges of HIV and emerging epidemics.

PI_NAMEs: CHIANG, SILVIA SHINPEI (contact)

PROGRAM_OFFICER_NAME: MOTEN, CARMEN

PROJECT_TERMS: Address;Award;Behavioral Sciences;Biometry;Clinical Research;Clinical Sciences;Collaborations;combat;Communities;COVID-19;Data;Dedications;Development;Diagnostic;Disease;Disease Outbreaks;Ebola;Education;Educational process of instructing;Emerging Communicable Diseases;Enrollment;Epidemic;Ethics;experience;Faculty;falls;Financial Support;Foundations;Funding;Future;Goals;Grant;hands on research;Health;Hepatitis C;HIV;HIV/AIDS;Hospitals;Human Papilloma Virus-Related Malignant Neoplasm;Infection;interest;Investigation;Manuscripts;marginalized community;Master of Science;Medical;Medical Residency;medical schools;Medical Students;meetings;men who have sex with men;Mentors;Mentorship;Microbe;Monkeypox;Multidrug-Resistant Tuberculosis;new epidemic;Outcome;Phase;Physicians;Preparation;Prevention;programs;Publications;Publishing;Reapplication;Research;Research Personnel;Research Project Grants;Research Proposals;Resources;response;Rhode Island;Role;Scholars Program;Science;Scientist;Severe Acute Respiratory Syndrome;Sexually Transmitted Diseases;Social Sciences;Structure;symposium;Syphilis;Time;tool;Training;Training Programs;treatment strategy;United States National Institutes of Health;Universities;Vaccines;Work;ZIKA

PROJECT_TITLE: Emerging Infectious Disease and HIV Scholars Program at Brown University


NIH_SPENDING_CATS: Biotechnology;Genetics;Immunization;Infectious Diseases;Prevention;Stem Cell Research;Stem Cell Research - Embryonic - Human;Vaccine Related

ORG_CITY: PITTSBURGH

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: NARRATIVE Live attenuated vaccines based on the same genetically heterogeneous virus are used to reduce chickenpox and zoster, but the basis of skin attenuation is unknown. The vaccine can be problematic in some recipients because it is genetically a mix. The work proposed here will show that attenuation involves changes in a VZV regulatory protein that influences DNA repair. The results may lead to a more defined vaccine candidate.

PI_NAMEs: KINCHINGTON, PAUL R. (contact)

PROGRAM_OFFICER_NAME: DUPUY, LESLEY CONRAD

PROJECT_TERMS: Adult;Affect;Alleles;Area;Attenuated;Attenuated Vaccines;attenuation;Automobile Driving;Binding;Biological Assay;cell type;Chickenpox;Chickenpox Vaccine;chromatin immunoprecipitation;chronic pain;Clinical;Complement;Country;Cytokeratin;Data;Defect;Development;Disease;DNA Damage;DNA Repair;epidermal stem cell;Epithelium;Exanthema;experience;Experimental Models;Filament;Foundations;Ganglia;Gene Expression;Gene Frequency;Genes;genetic regulatory protein;Genetic Transcription;Genotype;Growth;Herpes zoster disease;Herpesviridae;Herpesvirus Type 3;Human;human embryonic stem cell;Immunity;Immunize;improved;Incidence;Infection;Infectious Skin Diseases;insight;keratinocyte;keratinocyte differentiation;Life Cycle Stages;Link;Modeling;Mutation;neuronal growth;Neurons;novel;overexpression;Pain;Parents;Pathway interactions;Phenotype;prevent;promoter;Proteins;Public Health;reactivation from latency;recombinant virus;Recombinants;Reporter;response;Risk;Simplexvirus;Single Nucleotide Polymorphism;Skin;stem cells;Stimulus;System;Target Populations;Testing;Trans-Activators;Up-Regulation;uptake;vaccine candidate;Vaccines;varicella-zoster virus immediate early protein 62;Viral Genes;Virus;Virus Diseases;Virus Latency;Virus Replication;VZV vaccine;Work;Zoster Vaccine

PROJECT_TITLE: VZV vaccine attenuation and the DNA damage response

STUDY_SECTION: VIRA

STUDY_SECTION_NAME: Virology - A Study Section[VIRA]