NIH_SPENDING_CATS: Breast Cancer;Cancer;Women's Health Research

ORG_CITY: RICHLAND

ORG_NAME: BATTELLE PACIFIC NORTHWEST LABORATORIES

PHR: NARRATIVE  Our proposed research is relevant to public health and addresses NIH PAR-23-058 “NCI Small Grants Program for Cancer Research for Years 2023, 2024, and 2025” since we aim to generate an improved understanding of the BRCA1-PALB2-BRCA2 axis. These core proteins are well documented to play a role in breast and other cancers and yet structural information remains sparse for the individual proteins and larger heterocomplex. We will combine advanced cell-free expression techniques to generate wild type and full-length proteins then perform cryo-Electron Microscopy and Native Mass Spectrometry to determine the structure of the assembled heterocomplex and resolve structures of BRCA1, PALB2 and BRCA2.

PI_NAMEs: EVANS, JAMES E (contact)

PROGRAM_OFFICER_NAME: COUCH, JENNIFER A

PROJECT_TERMS: 3-Dimensional;Address;Adopted;Architecture;BARD1 gene;Basic Science;Binding;Biochemical;biophysical techniques;BRCA1 gene;BRCA2 gene;Breast;Budgets;cancer prevention;Cancer Research Project;cancer type;Cells;Characteristics;Collection;Complex;Core Protein;Coupled;Cryoelectron Microscopy;Data;density;detector;Development;Disease;DNA Binding;DNA Repair;Electron Microscope;Electrophoresis;empowerment;Feasibility Studies;flexibility;Foundations;Funding Opportunities;Gel Chromatography;Genes;Genome Stability;Goals;Grant;Hour;image processing;image reconstruction;improved;In Vitro;Individual;innovation;insight;Kinetics;Length;Life;Maintenance;Malignant Breast Neoplasm;Malignant neoplasm of ovary;Malignant Neoplasms;Maps;Mass Spectrum Analysis;Modeling;Molecular;Molecular Conformation;Molecular Mechanisms of Action;molecular phenotype;mutant;Mutation;Outcome;PALB2 gene;particle;Pathway interactions;Physiological;Preparation;preservation;Process;Production;protein structure;Proteins;Protocols documentation;Public Health;Reaction;Research;Research Project Grants;Research Proposals;Resolution;Risk;Sampling;scale up;screening;Solubility;stoichiometry;Structure;success;targeted treatment;Techniques;Testing;three dimensional structure;Tube;Tumor Suppressor Proteins;United States National Institutes of Health;Variant;Visualization;Work

PROJECT_TITLE: Structure of the BRCA1-PALB2-BRCA2 complex

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-A (J1)]


ADMINISTERING_IC: EY

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision

ORG_CITY: HANOVER

ORG_COUNTRY: UNITED STATES

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_FIPS: US

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: Narrative Not applicable.

PI_NAMEs: LEIB, DAVID A (contact)

PROGRAM_OFFICER_NAME: MCKIE, GEORGE ANN

PROJECT_TERMS: Disease;Integration Host Factors;Viral

PROJECT_TITLE: Viral and Host Factors in Herpetic Diseases


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Digestive Diseases;Genetics;Human Fetal Tissue;Infant Mortality;Infectious Diseases;Microbiome;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention

ORG_CITY: PITTSBURGH

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project Narrative Group B Streptococcus is one of the most common causes of invasive bacterial infections during the newborn period, contributing to serious adverse outcomes such as sepsis with organ failure, meningitis and brain injury, and death. We propose studies that will help establish how group B Streptococcus is able to attach to the newborn intestinal surface, which sets the stage for later bloodstream invasion and serious illness. This work will add to our understanding of consequential newborn infections and may identify molecular targets that could be used in future efforts to develop new ways to prevent or treat illness from group B Streptococcus.

PI_NAMEs: HOOVEN, THOMAS A (contact)

PROGRAM_OFFICER_NAME: GU, XIN-XING

PROJECT_TERMS: adverse outcome;Affect;Animals;antenatal;Antibiotic Prophylaxis;Antibiotics;Antibodies;Antibody Therapy;Bacterial Adhesins;Bacterial Infections;Bacterial Proteins;Binding;Biology;Birth;Blood Circulation;Brain Injuries;Cerebral Palsy;Cessation of life;Child;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;design;Development;Dimensions;Disease;disease model;early onset;early onset sepsis;enteric infection;Enzymes;Epithelial Attachment;Epithelial Cells;experimental study;Face;fetal;Future;Gene Deletion;Gene Expression;Gene Expression Profiling;gene repression;Genetic;Genetic Transcription;gut colonization;Human;human disease;human fetus tissue;Image;Immune Evasion;in vivo Model;Incidence;Infant;infant morbidity/mortality;Infection;Inflammatory;innovation;Institution;Interruption;intestinal epithelium;Intestines;intrapartum;Invaded;Investigation;knock-down;Knock-out;Late-Onset Disorder;Libraries;Life;Measures;Mediating;member;Meningitis;Modification;Molecular Target;Morbidity - disease rate;Mothers;mouse model;Mucous Membrane;Mus;mutant;Neonatal;neonatal infection;neonatal morbidity;Neonatal Mortality;Newborn Infant;novel;Organ failure;Pathogenesis;Pathway interactions;Perinatal;pharmacologic;Phenotype;Policies;postnatal;prevent;Process;prophylactic;Proteins;Regulatory Pathway;Regulon;Reporter Genes;response;Risk;Role;Sampling;screening;Sepsis;Serotyping;Signal Transduction;Streptococcal Infections;Streptococcus CAMP protein;Streptococcus Group B;Surface;Survivors;System;Techniques;Testing;tool;transcriptome sequencing;transcriptomics;United States;Vaccination;Vaccines;Validation;Virulence;Work

PROJECT_TITLE: Group B Streptococcus surface determinants of neonatal intestinal colonization and infection

STUDY_SECTION: PN

STUDY_SECTION_NAME: Pregnancy and Neonatology Study Section[PN]


ADMINISTERING_IC: CA

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Breast Cancer;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Social Determinants of Health;Women's Health Research

ORG_CITY: Chicago

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE The objective of the proposed feasibility and acceptability pilot study is to capture lived experiences of breast cancer patients and characterize their knowledge types, levels, and gaps longitudinally. In a collaboration between human factors researcher, medical oncologist, and a patient partner, we will conduct semi-structured Cognitive Task Analysis interviews with 35 adult breast cancer patients to elicit experiences longitudinally (prior to first treatment, 6 months and 1 year after diagnosis). We will analyze interview data using thematic analysis and develop taxonomy of patient knowledge across the care continuum.

PI_NAMEs: PAPAUTSKY, ELIZABETH LERNER (contact)

PROGRAM_OFFICER_NAME: SARMA, ELIZABETH ANNE

PROJECT_TERMS: acceptability and feasibility;Adherence;Adult;Advocacy;American Cancer Society;American Society of Clinical Oncology;Area;Behavior;breast cancer diagnosis;Breast Cancer Patient;Cancer Center;cancer health disparity;Caring;Clinic;Clinical;cognitive task;Collaborations;Communities;Comprehension;Continuity of Patient Care;Cues;Data;Decision Making;design;Development;Diagnosis;Elements;Event;experience;Hospitalization;Human;human centered design;Illinois;inner city;insight;Internet;Interview;Knowledge;Knowledge acquisition;Literature;Lived experience;low health literacy;Malignant Breast Neoplasm;Managed Care;Medical;Medical Oncologist;Methods;multidisciplinary;National Cancer Institute;Neutropenic Fever;Non-Insulin-Dependent Diabetes Mellitus;novel;Nurses;Outcome;Patient Education;patient engagement;patient population;Patients;Performance;Phase;Pilot Projects;Play;Population;Professional Organizations;Prognosis;Provider;Psychologist;Qualitative Methods;Quality of life;recruit;Reporting;Research;Research Methodology;Research Personnel;Resources;screening;Self Care;Sepsis;side effect;social media;Source;Structure;symposium;task analysis;Taxonomy;Techniques;Time;treatment adherence;Treatment Side Effects;Trust;Twitter;underserved community;Underserved Population;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Using Qualitative Methods to Capture Experiences of Breast Cancer Patients and Characterize Knowledge Types and Levels: The First Step in Informing Patient Knowledge Sharing

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-2 (J2)]


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF OSTEOPATHIC MEDICINE

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cardiovascular;Heart Disease;Hypertension

ORG_CITY: WEST DES MOINES

ORG_DEPT: PHYSIOLOGY

ORG_NAME: DES MOINES UNIV OSTEOPATHIC MEDICAL CTR

ORG_STATE: IA

PHR: PROJECT NARRATIVE Reduced nitric oxide availability is a key factor in the pathophysiology of many cardiovascular diseases. While nitric oxide donors are used in practice, nitrate tolerance and development of endothelial dysfunction limit their clinical efficacy. In this project, we will develop a novel peptide that promotes endogenous production of nitric oxide through a unique mechanism of action leading to vasorelaxation and anti-inflammatory effects while protecting endothelial cell function.

PI_NAMEs: TRAN, KIM  (contact)

PROGRAM_OFFICER_NAME: CHARETTE, MARC F

PROJECT_TERMS: Affect;Affinity;Agonist;Anesthesia procedures;Angiotensin II;Antiinflammatory Effect;Aorta;Attenuated;Binding;blood pressure elevation;blood pressure reduction;Blood Vessels;Cardiovascular Diseases;Cardiovascular system;Cell Adhesion Molecules;Cell Physiology;Cells;Clinical;clinical efficacy;Cyanides;cytokine;Cytoplasm;Data;Data Analyses;design;Development;dimer;Disodium Salt Nitroprusside;Endoplasmic Reticulum;endoplasmic reticulum stress;Endothelial Cells;endothelial dysfunction;Endothelium;Epitopes;ESR1 gene;Estrogens;Event;Functional disorder;Goals;GPER gene;graduate student;Heart failure;Heart Hypertrophy;Hypertension;hypertensive;Inbred SHR Rats;Inflammation;Intravenous;intravenous injection;Mediating;Medical;Medical Students;Membrane Proteins;Modeling;Molecular Conformation;Myocardial Ischemia;neutralizing antibody;Nitrates;Nitric Oxide;Nitric Oxide Donors;normotensive;novel;novel strategies;Outcomes Research;Penetration;Peptides;Poisoning;Process;Production;programs;Proliferating;Property;Proteins;Publications;Rattus;receptor;Research Personnel;response;Risk;Signal Transduction;Smooth Muscle;Smooth Muscle Myocytes;STIM1 gene;Stroke;Stromal Change;student training;success;Testing;Therapeutic;Universities;Vascular Smooth Muscle;vasoconstriction;Vasoconstrictor Agents;Vasodilation;voltage;Work

PROJECT_TITLE: Development of a Novel Vasorelaxing Peptide

STUDY_SECTION: IVPP

STUDY_SECTION_NAME: Integrative Vascular Physiology and Pathology Study Section[IVPP]


NIH_SPENDING_CATS: Biotechnology;Cancer;Prostate Cancer;Radiation Oncology;Urologic Diseases

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

ORG_STATE: NY

PHR: PROJECT NARRATIVE: Radiation therapy is commonly used to cure prostate cancers, including cancers confined to the prostate gland itself as well as prostate cancer that has spread to surrounding lymph nodes or other tissues. However, many patients are not cured of prostate cancer after radiotherapy due to restrictions in dose required by the limited radiation tolerance of adjacent normal tissues. In this proposal, we will attempt to develop a novel therapeutic drug that could improve outcomes for these patients by sensitizing only prostate cancer cells to the effects of radiotherapy and spare other tissues, such as bowel.

PI_NAMEs: HIGGINSON, DANIEL  (contact)

PROGRAM_OFFICER_NAME: PEREZ, J MANUEL

PROJECT_TERMS: Address;Anatomy;Antibody-drug conjugates;Biopsy;Bladder;cancer therapy;Cathepsins;Cell Death;cell killing;Cell Line;Cells;Cisplatin;Clinical;Complex;curative treatments;cytotoxic;Cytotoxic agent;Defecation;design;Development;Dipeptides;Disease;DNA Damage;DNA Double Strand Break;DNA-dependent protein kinase;Dose;Dose Limiting;draining lymph node;efficacy evaluation;enhancing factor;External Beam Radiation Therapy;Failure;FDA approved;FOLH1 gene;follow-up;Goals;Grant;Hemorrhage;high risk;Immunohistochemistry;improved;improved outcome;In Vitro;in vitro activity;in vitro testing;in vivo;Increased frequency of micturition;inhibitor;Intestines;irritation;kinase inhibitor;Lead;Ligand Binding;Ligands;Link;Linker DNA;lymph nodes;Malignant neoplasm of prostate;Malignant Neoplasms;Mediating;men;Modeling;Modernization;Molecular;Mus;Nature;neoplastic cell;Normal tissue morphology;novel;novel therapeutics;Outcome;Patient-Focused Outcomes;Patients;Pelvic lymph node group;Pelvis;Pharmaceutical Preparations;phase III trial;Phosphotransferases;Positron-Emission Tomography;Property;Prostate;prostate cancer cell;prostate cancer cell line;prostate cancer model;prostate cancer risk;Prostate Cancer therapy;prostate radiotherapy;Quality of life;Radiation;Radiation Accidents;Radiation Dose Unit;radiation effect;Radiation therapy;Radiation Tolerance;Radiation-Sensitizing Agents;Radioisotopes;Radionuclide Imaging;Radiosensitization;radiotracer;Radium;Rectum;repaired;Research Project Grants;Resistance;response;Role;side effect;Site;Small Intestines;small molecule inhibitor;Surface Antigens;targeted treatment;Techniques;Testing;Therapeutic;therapeutic development;Therapeutic Index;Tissues;Toxic effect;Treatment Efficacy;tumor;tumor growth;Tumor Tissue;Urethra;urinary;Western Blotting;Work;Xenograft Model;Xenograft procedure

PROJECT_TITLE: PSMA ligand radiosensitizers to improve the therapeutic index of external beam radiotherapy for prostate cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-X (J2)]


ADMINISTERING_IC: MD

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Suicide;Suicide Prevention

ORG_CITY: Newark

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: PROJECT NARRATIVE Despite recent evidence that Black sexual and gender minority (SGM) adolescents and young adults (AYA) are at inequitable and increasing suicide risk, little research has examined forms of structural oppression as drivers of these trends. In this study, we will establish a large nationwide cohort of Black SGM AYA and follow them longitudinally to examine socio-structural predictors (e.g., state laws, policies, and social climate indicators of racism, anti-SGM stigma, mental health stigma, and their intersections) of suicide thoughts and behaviors (STBs) and proximal mediators of STBs. We will integrate Intersectionality frameworks and the social ecological model to identify modifiable socio-structural targets for future transformational public health policy and community-level intervention that reduce population-level suicide inequities for Black SGM AYA in line with the 2019 Congressional Black Caucus Taskforce “Ring the Alarm” report’s call to action.

PI_NAMEs: BUSBY, DANIELLE R;ENGLISH, DEVIN  (contact)

PROGRAM_OFFICER_NAME: BARKSDALE, CRYSTAL

PROJECT_TERMS: Adolescent;Adolescent and Young Adult;Advisory Committees;Affect;Age;Anxiety;Award;Black Populations;Black race;care providers;cohort;Color;Communities;community intervention;comparative;Congresses;Critical Race Theory;Data;Databases;demographics;Development;digital;Enrollment;Face;Feeling suicidal;follow-up;Funding;Future;Gays;gender minority community;gender minority youth;Generations;Grant;hate crimes;Health;Health Disparities Research;Health Policy;Heterosexuals;high risk;HIV;Individual;Inequity;Infrastructure;Internet;intersectionality;Intervention;Investments;Laws;Link;Literature;Mediation;Mediator;Mental disorders;Mental Health;Modeling;Mood Disorders;multidisciplinary;National Institute on Minority Health and Health Disparities;Nature;nonbinary;novel;Online Systems;Participant;Policies;policy recommendation;Population;protective factors;psychologic;Psychotherapy;Public Health;Puerto Rico;racial population;racism;recruit;reducing suicide;Reporting;Research;Research Personnel;research study;Resources;response;Risk;Risk Factors;Role;Sampling;School-Age Population;Schools;Sexual and Gender Minorities;sexual minority youth;social;Social Environment;social stigma;social structure;Social Work;sociodemographics;Source;Stigmatization;structural determinants;Structural Racism;substance use;suicidal;suicidal behavior;suicidal risk;Suicide;Suicide attempt;suicide model;Suicide prevention;Surveys;Techniques;Testing;Translating;trend;working group;Youth

PROJECT_TITLE: Understanding the Role of Structural Oppression for Suicide Risk among Black Sexual and Gender Minority Adolescents and Young Adults

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-N (02)]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences

ORG_NAME: NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC

PHR: Project Narrative Serotonin potently regulates brain activity and plasticity, and many medications for depression and anxiety act on serotonin. However, targeted treatments are limited because we have a poor understanding of how the serotoninergic system is organized throughout the brain. This project will address that problem by mapping the brain-wide architecture of the serotonergic system.

PI_NAMEs: MILLER, BRADLEY  (contact)

PROGRAM_OFFICER_NAME: LEINWAND, SARAH GOLDBERG

PROJECT_TERMS: Adult;Affect;Aggressive behavior;Agreement;Anatomy;Animals;Anxiety;Architecture;Area;Axon;Back;Bar Codes;behavioral response;blind;Brain;Brain Mapping;Brain region;cell type;Cells;Code;cognitive function;connectome;Dedications;Development;Diagnosis;Dorsal;emotional behavior;emotional functioning;Face;Flying body movement;Future;Graph;Head;healing;Heterogeneity;Image;in situ sequencing;Individual;innovation;interest;Knowledge;Lasers;Learning;Link;Location;Maps;Medial;Mental Depression;Mission;Molecular;Multiplexed Analysis of Projections by Sequencing;Mus;National Institute of Mental Health;neural circuit;Neuroanatomy;Neuromodulator;Neurons;neuropsychiatry;neuroregulation;Neurotransmitters;novel strategies;Pattern;Pharmaceutical Preparations;Property;Psychiatry;raphe nuclei;Resolution;RNA;Role;scaffold;Serotonergic System;Serotonin;Serotonin Agents;sex;Shock;Sleep;Social Behavior;Strategic Planning;Stress;Sucrose;System;targeted treatment;Technology;Therapeutic;Visualization;Weight;Work

PROJECT_TITLE: Building a Granular Brain-Wide Map of the Serotonin System

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-G (01)]


NIH_SPENDING_CATS: Cardiovascular;Heart Disease

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

ORG_STATE: CA

PHR: Project Narrative Recent data from our team suggests that normal sinus rhythm emerges from a highly heterogenous electrical network along the sino-atrial node set by the intrinsic properties of the cells in specific regions and regional variation in vascular supply. The experimental and computational work proposed in this application will unveil the mechanisms underlying cardiac pacemaking and may lead to the development of rational strategies for the treatment of rhythm disturbances during heart failure.

PI_NAMEs: CLANCY, COLLEEN E;CUDMORE, ROBERT HARRY;SANTANA, LUIS F (contact)

PROGRAM_OFFICER_NAME: TJURMINA, OLGA A

PROJECT_TERMS: Action Potentials;Adrenergic Agents;Biological;Blood Vessels;Cardiac;Cations;Cells;Characteristics;Computer Models;Consumption;cyclic-nucleotide gated ion channels;Data;Development;Disease;Electrophysiology (science);Event;Exhibits;Failure;Formulation;Frequencies;Functional disorder;Health;Heart;Heart Atrium;Heart failure;Human;Inferior;Investigation;Life;Mediating;Membrane;Membrane Potentials;Metabolic;Metabolic Control;Modeling;Muscarinics;Muscle Cells;Nature;Noise;Pathologic;Periodicals;Periodicity;Physiological;Physiology;Potassium Channel;Probability;Production;Property;Regulation;Sarcoplasmic Reticulum;sensor;Sick Sinus Syndrome;Signal Transduction;Sinoatrial Node;Sinus;Source;Testing;Time;treatment strategy;Variant;Vascular blood supply;Vascularization;Ventricular;voltage;Work

PROJECT_TITLE: Metabolic Control of Cardiac Pacemaking

STUDY_SECTION: BBHV

STUDY_SECTION_NAME: Basic Biology of Blood, Heart and Vasculature Study Section [BBHV]


ADMINISTERING_IC: GM

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities

ORG_CITY: RENO

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF NEVADA RENO

ORG_STATE: NV

PHR: Overall Network Organization and Management Plan – Narrative The IDeA Network for Biomedical Research Excellence (INBRE) program enhances Nevada’s biomedical research, training, and infrastructure, which strengthens healthcare and biomedical workforce and leadership in the state and makes Nevada researchers more competitive for federal research funding.

PI_NAMEs: BAKER, JONATHAN E. (contact)

PROGRAM_OFFICER_NAME: NANDA, JAGPREET SINGH

PROJECT_TERMS: Award;base;Bioinformatics;Biomedical Research;career;Cell Differentiation process;cell growth;Centers of Research Excellence;Cloud Computing;Collaborations;college;Communication;Communities;computerized data processing;COVID-19;Data Science Core;Data Storage and Retrieval;design;Development;Doctor of Philosophy;Education;Educational process of instructing;Educational workshop;Ensure;Equipment;experience;Faculty;Funding;Genomics;Goals;Grant;Growth;Health;Healthcare;Human;improved;Infrastructure;Institution;Interdisciplinary Study;interest;Lead;Leadership;medical schools;meetings;Mentorship;Minority;Mission;Nevada;outreach;outreach program;Privatization;Program Research Project Grants;programs;Proteomics;Research;research faculty;Research Infrastructure;Research Institute;Research Personnel;Research Project Grants;Research Support;Resources;response;Scientist;Services;Site Visit;Structure;Students;success;Time;Training;undergraduate research;undergraduate research experience;undergraduate student;Underrepresented Populations;Underrepresented Students;United States National Institutes of Health;Universities;web site;Work;Workforce Development;Writing

PROJECT_TITLE: Nevada IDeA Networks of Biomedical Research Excellence (INBRE)


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

ORG_CITY: MORGANTOWN

ORG_NAME: WEST VIRGINIA UNIVERSITY

ORG_STATE: WV

PHR: NARRATIVE The purpose of this project is to determine and validate the full operational parameters of a novel combustion generation system in the WVU Center for Inhalation Toxicology: a surrogate military burn pit generator. The conditions of combustion in burn pits varies tremendously and the resultant emissions generated also vary tremendously. Completion of this project will identify: proportions of combustion elements, parameters of operation, characterize emission aerosols in a whole-body rodent inhalation exposure chamber, and validate these parameters for subsequent animal models of burn pit exposures to study chronic multisymptom illness in U.S. Veterans.

PI_NAMEs: NURKIEWICZ, TIMOTHY R (contact)

PROGRAM_OFFICER_NAME: NADADUR, SRIKANTH

PROJECT_TERMS: Address;Aerosols;Afghanistan;Air;Animal Model;Area;base;Behavior Disorders;burn pit;Cardiopulmonary;Cardiovascular system;Characteristics;Chronic;Complex;Dedications;Development;Diagnosis;Dose;Electronics;Elements;Environment;Exposure to;Failure;Fatigue;Fire - disasters;first responder;Foundations;Future;Generations;Goals;Gulf War veteran;hazard;Health;Human Resources;immune function;Impaired cognition;Incidence;Inhalation;Inhalation Exposure;Inhalation Toxicology;instrument;Investigation;Iraq;Kerosene;Knowledge;Label;Laboratory Animals;Laws;Lubricants;Lung;manufacture;Medical;Metals;Methods;Middle East;Military Personnel;minimal risk;Modeling;Morbidity - disease rate;novel;operation;Pain;Paint;Paper;particle;Patients;Persian Gulf Syndrome;Petroleum;Plastics;prevent;Process;programs;propellant;Public Health;Pump;Refuse Disposal;Reproducibility;Research;Rewards;Risk;Risk Factors;Rodent;Rubber;Sampling;service member;Silicon Dioxide;Soldier;Solid;Speed;Surface;Symptoms;System;Temperature;Time;Tissues;toxicant;United States;Universities;Validation;Variant;Veterans;virtual;wasting;West Virginia;Wood material;Xenobiotics

PROJECT_TITLE: Validation of a military burn pit surrogate generator and aerosol exposure system

STUDY_SECTION: EDD

STUDY_SECTION_NAME: Environmental Determinants of Disease Study Section [EDD]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Depression;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurodegenerative;Prevention;Social Determinants of Health;Telehealth

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: Narrative Subjective cognitive decline (SCD) may be a pre-clinical stage of Alzheimer’s Disease and is closely linked to depression. We propose to adapt a peer support depression care intervention for older adults with SCD and depression to inform appropriate management of depression in SCD and understand the impact of decreasing depression in SCD, with the potential to prevent progression to AD.

PI_NAMEs: JOO, JIN HUI  (contact)

PROGRAM_OFFICER_NAME: RICE, ELISE

PROJECT_TERMS: acceptability and feasibility;Active Listening;Address;Adult;adult of color;Age Years;Aging;Alzheimer's Disease;Alzheimer's disease risk;barrier to care;behavior change;Caring;Clinical;clinical care;Cognitive;cognitive change;cognitive testing;cohort;Color;Communication;communication behavior;Communities;community collaboration;community engaged approach;community engagement;Community Healthcare;community intervention;community organizations;community setting;Complex;Coping Skills;Data;depressive symptoms;Distress;Early identification;Eligibility Determination;Emotional;emotional functioning;enhanced care;ethnic diversity;Ethnic Origin;experience;Face;Focus Groups;Funding;Future;Goals;health literacy;Impaired cognition;Impairment;implementation facilitators;implementation framework;implementation intervention;Intervention;intervention participants;Intervention Studies;Interview;Knowledge;Language;Link;Loneliness;Low income;Manuals;Massachusetts;Measures;Mediator;meetings;Mental Depression;Mental Health;Modeling;National Institute of Mental Health;Neurobehavioral Manifestations;older adult;Outcome Measure;Participant;Patient Self-Report;peer;peer coaching;peer support;Perception;Persons;Physical Function;Pilot Projects;post intervention;pre-clinical;Prevalence;prevent;Procedures;programs;Psyche structure;Randomized, Controlled Trials;recruit;Reporting;Research;Resources;Risk;Self Care;Self Efficacy;skills;Social Functioning;social learning;Social support;socioeconomics;Standardization;stressor;Structure;subthreshold depression;Symptoms;Testing;theories;Training;United States National Institutes of Health;video chat;virtual;Work

PROJECT_TITLE: Developing a Peer Support Intervention for Depression in SCD

STUDY_SECTION: HPC

STUDY_SECTION_NAME: Health Promotion in Communities Study Section[HPC]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Clinical Research;Contraception/Reproduction;Endometriosis;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pain Research;Prevention;Racial and Ethnic Minority Health Research;Women's Health Research

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: PROJECT NARRATIVE Endometriosis is a common and debilitating gynecologic disorder that affects approximately 10% of persons born with internal reproductive organs. To date, there has been almost no research on risk factors for or consequences of endometriosis among Black women and this is a significant gap as many established risk factors for endometriosis differ in their prevalence between Black and White women. This study will be the first ever study on risk factors and consequences of endometriosis among Black women.

PI_NAMEs: HARRIS, HOLLY RUTH (contact);PETRICK, JESSICA L

PROGRAM_OFFICER_NAME: TINGEN, CANDACE M

PROJECT_TERMS: access disparities;Address;Affect;Age at Menarche;Autoimmune Diseases;Biological;Birth Weight;black women;Body mass index;Body Size;cancer risk;Cardiovascular Diseases;Chronic;Chronic Disease;chronic pelvic pain;Clinical;cohort;comorbidity;Complex;Data;Diagnosis;diagnosis standard;Diagnostic;Disease;Dysmenorrhea;economic impact;Endometrial;endometriosis;Epidemiologic Methods;ethnic difference;experience;Fatigue;Funding;Grant;Gynecologic;Health;Health Care Costs;health equity;Health Services Accessibility;Heterogeneity;High Prevalence;high risk;Hysterectomy;Incidence;Infertility;Knowledge;Length;Life Cycle Stages;Literature;Longitudinal cohort;Malignant neoplasm of ovary;Measurement;Menstrual cycle;Methodology;Methods;Morbidity - disease rate;Not Hispanic or Latino;novel;Outcome;Ovarian Endometriosis;Pain;parity;Participant;Patient Self-Report;Pattern;Persons;Population;Prevalence;Prospective cohort;Prospective Studies;Quality of life;racial difference;reproductive organ;Research;Rheumatoid Arthritis;Risk;Risk Factors;Severities;Sjogren's Syndrome;Symptoms;Systemic Lupus Erythematosus;Tissues;Uterine Fibroids;Uterus;validation studies;White Women;Women's Health;Work

PROJECT_TITLE: Risk factors for and consequences of endometriosis among Black women

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-J (96)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Dementia;Emergency Care;Health Services;Neurodegenerative;Palliative Care

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE For Veterans living with dementia and their caregivers, one of the most critical choices during an ED visit is the decision to be admitted to the hospital or to be discharged home. There are significant risks associated with either choice, such as hospital-acquired infections when admitted, or return ED visits when discharged. This research project seeks to develop a shared decision making tool that will help Veterans living with dementia, their caregivers, and ED health care providers have conversations about risks, benefits and what matters most, in order to make a disposition decision that is aligned with patient and caregiver values and preferences.

PI_NAMEs: VAN HOUTVEN, COURTNEY HAROLD (contact)

PROGRAM_OFFICER_NAME: NGUYEN, EMERALD THAI HAN

PROJECT_TERMS: acceptability and feasibility;Accident and Emergency department;Acute;Admission activity;Area;Award;care coordination;care delivery;career;career development;Caregivers;Caring;Characteristics;cohort;Collaborations;Communities;comorbidity;Complex;cost;Data;Decision Aid;Delirium;Dementia;Dementia caregivers;design;Development;Effectiveness;Elements;Emergency Care;Emergency department visit;Emergency Medicine;Equilibrium;experience;Feedback;functional decline;Goals;Health Personnel;Health Professional;Health Services;Health Services Research;Home;Hospitalization;Hospitals;insight;Instruction;International;Intervention;Interview;Learning;Measures;Mentors;Mentorship;Methods;Modeling;multidisciplinary;Nosocomial Infections;Outcome;patient population;Patient-Focused Outcomes;Patients;Persons;Pharmaceutical Preparations;Physicians;Pilot Projects;pilot test;Play;Population;Positioning Attribute;preference;Process;prototype;Provider;Qualitative Methods;Recording of previous events;Research;Research Design;Research Personnel;Research Priority;Research Project Grants;Risk;Role;Scientist;shared decision making;skill acquisition;skills;social;sociodemographics;surrogate decision making;Testing;Time;tool;Training;Uncertainty;usability;Variant;Veterans;Visit

PROJECT_TITLE: Dementia and Value of Home Time


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Congenital Heart Disease;Congenital Structural Anomalies;Genetics;Heart Disease;Kidney Disease;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Polycystic Kidney Disease;Rare Diseases

ORG_CITY: SALT LAKE CITY

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Project Narrative This proposal aims to elucidate the structural principles and channel properties of polycystic kidney disease proteins, which are the sites of mutations that cause autosomal dominant polycystic kidney disease, biliary atresia, and congenital heart defects. Treatment options for these genetic disorders are currently limited, in large part because the molecular mechanisms of the relevant proteins are only poorly understood. Successful outcome will inform the development of therapeutic strategies that counteract the molecular defects of relevant polycystic kidney disease proteins.

PI_NAMEs: CAO, ERHU  (contact)

PROGRAM_OFFICER_NAME: MARIC-BILKAN, CHRISTINE

PROJECT_TERMS: Architecture;Autosomal Dominant Polycystic Kidney;Biliary Atresia;Binding;Biochemical;Biochemistry;Biological Assay;Biological Markers;Biology;Cations;causal variant;Cell secretion;Cells;Chemicals;Cilia;Classification;Comparative Study;Complex;Congenital Heart Defects;Cryoelectron Microscopy;Defect;Development;Diagnosis;Diagnostic;Disease;Disease Progression;Enzyme-Linked Immunosorbent Assay;extracellular vesicles;Family;Future;genetic association;Genetic Diseases;Genetic Transcription;Goals;Handedness;Human;Human Genetics;human model;insight;intercellular communication;Investigation;Ion Channel;Ion Channel Gating;Ions;Kidney;kidney cell;kidney epithelial cell;Kidney Failure;Lead;Left;Maintenance;male;Measures;Mechanics;Mediating;member;Membrane;Membrane Proteins;Mendelian disorder;MicroRNAs;model organism;Molecular;Mutagenesis;Mutate;Mutation;Nephrons;novel therapeutics;Nucleic Acids;Organ;Outcome;Pathogenicity;Pathway interactions;Patients;Pattern;pharmacologic;Play;Polycystic Kidney Diseases;Process;prognosis biomarker;prognostic;programs;Property;protein complex;Protein Family;Proteins;Rationalization;receptor;Regulation;Reporting;Reproduction;Role;sensor;Sensory;Sensory Process;Signal Transduction;Site;Situs Inversus;sperm cell;Sperm Motility;Stimulus;stoichiometry;Structure;Structure-Activity Relationship;success;Testis;therapeutic development;Therapeutic Intervention;therapeutically effective;Time;Translating;TRP channel;Tubular formation;urinary;Urine;vertebrate embryos;voltage

PROJECT_TITLE: Structural Mechanisms of Polycystic Kidney Disease Proteins

STUDY_SECTION: BBM

STUDY_SECTION_NAME: Biochemistry and Biophysics of Membranes Study Section[BBM]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Clinical Research;Contraception/Reproduction;Maternal Health;Maternal Morbidity and Mortality;Regenerative Medicine;Women's Health Research

ORG_CITY: Pittsburgh

ORG_NAME: MAGEE-WOMEN'S RES INST AND FOUNDATION

PHR: PROJECT NARRATIVE Avulsion of the pubovisceral muscle from the pubic bone at vaginal birth is one of the primary mechanisms leading to the development of pelvic organ prolapse later in life; yet, this injury is largely ignored since there are currently no strategies for repair. Here we propose to define the pathological changes that follow avulsion and physiologic recovery to inform the design of novel and effective therapeutic solutions to the benefit of women world-wide.

PI_NAMEs: LU, HELEN H;MOALLI, PAMELA A. (contact)

PROJECT_TERMS: 3-Dimensional;Address;Affect;Age;aging population;Animals;Biomechanics;Biomimetics;bone;Caring;Cell Culture Techniques;Cells;Childbirth;Chronic Disease;Clinical Research;Collagen Fiber;Complex;Computer Models;Connective Tissue;Conventional Surgery;cost estimate;Cues;Data;design;Development;Diagnostic;diagnostic criteria;Diameter;Disease;Elements;Engineering;Ensure;Event;Failure;Fiber;Fibroblasts;Fibrosis;healing;High Prevalence;Histologic;improved;In Vitro;in vivo;Incentives;Incidence;Injury;injury and repair;Intervention;Knowledge;levator ani muscle;Life;Link;Magnetic Resonance Imaging;mechanical signal;Mechanics;mineralization;Minerals;Modeling;Molecular;Muscle;nanofiber;Natural regeneration;nonhuman primate;novel;Operative Surgical Procedures;Organ;Outcome;Pathologic;Pathway interactions;Patients;pelvic organ prolapse;Pelvis;Penetration;Physiological;Population;pre-clinical;preclinical study;pubis bone structure;Public Health;Rattus;Recovery;Rectum;repair strategy;repaired;response;Rotator Cuff;scaffold;Shapes;simulation;standard of care;Stretching;Structure;Surface;Surgical sutures;Tendon structure;Testing;therapeutically effective;therapy design;Time;Tissues;translational potential;Ultrasonography;ultrasound;Urethra;Vagina;Vaginal delivery procedure;Woman

PROJECT_TITLE: Pubovisceral muscle enthesis injury: A bioinspired approach to repair

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-Q (95)]


NIH_SPENDING_CATS: Chronic Obstructive Pulmonary Disease;Genetics;Human Genome;Lung

ORG_CITY: NEW HAVEN

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Chronic obstructive pulmonary disease (COPD) is a leading cause of death in the United States for which there is no cure. In this study, we will utilize high-throughput RNA sequencing technologies, proteomics, spatial profiling, and network analyses to understand how aberrant cells in COPD communicate with their local environment. We believe that this may identify new therapeutic targets for COPD.

PI_NAMEs: SAULER, MAOR  (contact)

PROGRAM_OFFICER_NAME: LU, QING

PROJECT_TERMS: Atlases;Automobile Driving;biobank;Biological;Biological Specimen Banks;Cause of Death;Cell Communication;Cells;Chronic Disease;Chronic Obstructive Pulmonary Disease;chronic respiratory disease;Clinical;Collaborations;Collection;Communication;Data;Data Set;Disease;disease heterogeneity;Disease Progression;Environment;Extracellular Matrix;Formalin;Freezing;Funding Opportunities;Future;Gene Expression Profile;Genetic Transcription;Goals;High-Throughput RNA Sequencing;Individual;intercellular communication;Interruption;Investigation;Label;Link;Lung Diseases;Maps;Mass Spectrum Analysis;Measurement;Mission;National Heart, Lung, and Blood Institute;new therapeutic target;novel;novel therapeutic intervention;Nuclear RNA;Paraffin Embedding;Pathologic;Pathway Analysis;Phenotype;Population;Predisposition;Proteomics;Research;Research Personnel;Research Proposals;response;Sampling;Severity of illness;Signal Pathway;Signal Transduction;single cell sequencing;single nucleus RNA-sequencing;single-cell RNA sequencing;Structure of parenchyma of lung;Symptoms;Syndrome;Technology;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;Tissue Embedding;Tissue Sample;Tissues;trait;transcriptome sequencing;transcriptomics;United States;United States National Institutes of Health

PROJECT_TITLE: Local cellular communication networks in COPD endotypes

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-K (J1)]


NIH_SPENDING_CATS: Aging;Bioengineering;Clinical Research;Data Science;Eye Disease and Disorders of Vision;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_NAME: SCHEPENS EYE RESEARCH INSTITUTE

PHR: Project Narrative This project will develop novel deep learning models to improve performance equity in automated glaucoma detection, which will greatly benefit racial and ethnic minorities and socioeconomically disadvantaged groups with more equitable glaucoma screening. The novel deep learning models can be generalized to be used in other disease screening tasks to make a broader impact on various medical artificial intelligence applications. Equally important as our technical innovations, we will curate, clean, de-identify, and release a large dataset with 10,000 patients to the public including optical coherence tomography scans, fundus photos, glaucoma diagnostic data, and demographic identity information to facilitate a greater community of researchers to study medical artificial intelligence equity.

PI_NAMEs: WANG, MENGYU  (contact)

PROGRAM_OFFICER_NAME: GOVER, TONY DOUGLAS

PROJECT_TERMS: Affect;Area;Artificial Intelligence;Asian population;Awareness;Black Populations;Blindness;Caring;Classification;Clinic;Clinical;clinical implementation;Clinical Treatment;Communities;Data;data de-identification;Data Set;deep learning;deep learning model;demographics;Detection;Diagnosis;Diagnostic;Disease;Disparity;Ear;Economically Deprived Population;Equity;ethnic minority;ethnic minority population;Ethnic Origin;Eye;feasibility testing;Fundus;Gender;generative adversarial network;generative models;Glaucoma;Guidelines;health equity promotion;improved;Income;Individual;Inequity;innovation;Language;large datasets;Learning Module;Marital Status;Massachusetts;Measures;Medical;meetings;Methodology;Methods;Modeling;Motivation;network models;novel;optic nerve disorder;Optical Coherence Tomography;Patient Self-Report;Patients;Performance;Persons;Pharmacy facility;Primary Care;Race;racial minority;racial minority population;Reduce health disparities;Research;Research Personnel;retinal imaging;Risk Reduction;ROC Curve;Sampling;Scanning;screening;socioeconomic disadvantage;Specificity;synthetic data;System;Techniques;Training;training data;transfer learning;Vertebral column;Vision;Visit;Visual Fields;Weight

PROJECT_TITLE: Developing Equitable Deep Learning Models for Automated Glaucoma Screening

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-P (81)]


ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative Hemophilia A patients that are missing the protein factor VIII (FVIII) can be given FVIII as a medicine to control bleeding. Unfortunately, while some patients’ body react to the FVIII by creating an immune response that last even when the FVIII treatment is stopped, others make an immune response that disappears once the FVIII therapy is withdrawn. Because it is not known why and how patients’ bodies make different types of immune responses to FVIII, this grant will investigate a potential immune explanation for this and may contribute to finding strategies that can prevent this problem.

PI_NAMEs: PATEL, SEEMA RAJNIKANT (contact)

PROGRAM_OFFICER_NAME: WARREN, RONALD Q

PROJECT_TERMS: Address;Antibodies;Antibody Formation;B-cell receptor repertoire sequencing;B-Lymphocyte Subsets;B-Lymphocytes;biobank;Bioinformatics;Biological Assay;Bispecific Antibodies;Caring;CD4 Positive T Lymphocytes;Cell Physiology;Clinical;clinically relevant;Collection;Data;Deposition;design;Development;Disease;Disparate;Epitope Mapping;Exploratory/Developmental Grant;Factor VIII;Flow Cytometry;Future;gene therapy;Generations;Goals;Grant;Hematological Disease;Hemophilia A;Hemorrhage;high dimensionality;Immune;Immune response;Immune system;Immune Tolerance;Immunity;Immunoglobulin G;Immunoglobulin M;In Vitro;Infusion procedures;inhibitor;innovation;Lead;Letters;life-sustaining therapy;Measures;Medicine;Memory B-Lymphocyte;mimetics;Multicenter Hemophilia Cohort Study;National Heart, Lung, and Blood Institute;Neoadjuvant Therapy;neutralizing antibody;next generation sequencing;novel;novel therapeutics;Operative Surgical Procedures;Participant;participant enrollment;Pathway interactions;Patient Care;Patients;Peripheral Blood Mononuclear Cell;Pharmaceutical Preparations;Phenotype;Plasma;Plasma Cells;pre-clinical;prevent;Process;Production;Prophylactic treatment;Proteins;Reaction;recombinant antihemophilic factor VIII;Recording of previous events;Replacement Therapy;Reporting;Research;Research Personnel;Research Proposals;response;Site Visit;Specificity;Structure of germinal center of lymph node;T cell response;Testing;Therapeutic;Therapeutic Intervention;translational study;Variant;Withdrawal

PROJECT_TITLE: Defining immune pathways involved in the formation of antibodies against factor VIII


NIH_SPENDING_CATS: Aging;Cardiovascular;Estrogen;Genetics;Heart Disease;Human Genome;Nutrition;Obesity;Prevention;Women's Health Research

ORG_CITY: LOS ANGELES

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: NARRATIVE Women and men differ in the development of cardiovascular disease (CVD) risk factors such as obesity. CVD mortality in the population has decreased in the past 40 years, but women of ages 35–54 have experienced greater rates of hospitalization, and the incidence of CVD in women aged >60 has outpaced that in men. We have identified a specific gene on the X chromosome that promotes fat storage in females and will characterize its effects in fat cells at different points in the lifespan when gonadal hormone levels change.

PI_NAMEs: REUE, KAREN  (contact)

PROGRAM_OFFICER_NAME: GUPTA, DHANANJAY

PROJECT_TERMS: Adipocytes;Adipose tissue;Age;Age Years;aged;Andropause;cardiometabolism;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;Cause of Death;Cell Nucleus;Cells;Cessation of life;Chromatin Structure;Chromosomes;Cleavage Under Targets and Release Using Nuclease;cohort;Coronary Arteriosclerosis;Development;Disease;dosage;energy balance;Energy Metabolism;Enhancers;Enzymes;epigenetic regulation;experience;Fatty acid glycerol esters;Female;Gene Deletion;Gene Dosage;Gene Expression;Gene Expression Profile;Gene Expression Regulation;Generations;Genes;Genome;Gonadal Hormones;Gonadal Steroid Hormones;Health;histone demethylase;histone modification;Histones;Hormones;Hospitalization;hospitalization rates;Human;human male;improved;Incidence;Individual;Knowledge;life span;lipid biosynthesis;male;Maps;men;Menopause;middle age;mortality;Mus;Obesity;Ovary;Ploidies;Population;Postmenopause;Premenopause;prevent;programs;promoter;Property;Regulation;Reporting;response;Risk;Risk Factors;Role;sex;Sex Bias;Sex Differences;Tail;Testing;Testis;Therapeutic;Tissues;transcription factor;transcriptome sequencing;United States;Weight;Weight Gain;Woman;women versus men;Women's mortality;Women's prevalence;X Chromosome;X Inactivation

PROJECT_TITLE: A sex-biased obesity gene on the X chromosome


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Neurosciences;Orphan Drug;Radiation Oncology;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

PHR: PROJECT NARRATIVE This proposal will employ the emerging novel, robust, cell-based 3D brain organoid model that closely mimics the complexity of the human brain microenvironment to investigate the acute and late effects induced by radiation therapy on normal brain structures and functions, and to enable the development of adequate countermeasures by leveraging the established UCLA portfolio of radiation mitigators which have been identified with the high-throughput screen performed by the UCLA Center for Medical Countermeasures Against Radiation. Considering that patient-derived iPSCs may be leveraged to develop personalized testing models, our novel biomimetic model holds significant promise in the screening of patient-specific radiation mitigators in the era of precision medicine.

PI_NAMEs: HE, LING  (contact)

PROGRAM_OFFICER_NAME: PRASANNA, PAT G

PROJECT_TERMS: 3-Dimensional;Acute;Adult;Aftercare;Apoptosis;Astrocytes;Biological Assay;Biomimetics;blood-brain barrier penetration;Brain;Brain Injuries;Brain Neoplasms;brain tissue;Cell Death;Cell Proliferation;Cells;Central Nervous System;Clinical;Complex;Cranial Irradiation;Development;differentiation protocol;DNA;DNA Damage;DNA Double Strand Break;Dose;Drug Kinetics;experimental study;Exposure to;Fiber;fluoro jade;Free Radicals;Future;Gamma-H2AX;glial activation;Glial Fibrillary Acidic Protein;Goals;Hematopoietic System;high throughput screening;Histologic;Hour;Human;human induced pluripotent stem cells;Image;Impaired cognition;improved;induced pluripotent stem cell;Inflammation Mediators;Ionizing radiation;Late Effects;Lesion;Measurement;Medical center;medical countermeasure;Microglia;MMP2 gene;Modeling;Molecular Structure;nerve stem cell;Nervous System Disorder;nestin protein;Neuroglia;neuroinflammation;Neurologic;neuronal circuitry;Neuronal Differentiation;Neuronal Injury;Neurons;Normal tissue morphology;novel;Oncology;Organoids;patient derived induced pluripotent stem cells;patient screening;Patients;Pharmaceutical Preparations;phenylpiperazine;Physiological;Play;precision medicine;Process;Property;Quality of life;Radial;Radiation;radiation countermeasure;Radiation Dose Unit;radiation effect;Radiation exposure;radiation mitigation;radiation mitigator;Radiation therapy;radiological imaging;Reactive Oxygen Species;Research;response;Rodent Model;Role;screening;standard of care;stem;Structure;Symptoms;Testing;Therapeutic;Therapeutic Agents;Time;Toxic effect;Traction;tumor;two-photon;United States;vascular injury;Visualization

PROJECT_TITLE: Human brain organoids as a novel platform for evaluating effects of radiation in the CNS and screening for radiation mitigators


ED_INST_TYPE: OVERALL MEDICAL

NIH_SPENDING_CATS: Cancer;Digestive Diseases;Genetics;Pancreatic Cancer;Rare Diseases

ORG_CITY: COLLEGE STATION

ORG_NAME: TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR

ORG_STATE: TX

PHR: Oncogenic Ras signals through the poorly understood Ral oncogene, which in turn transduces signals via the exocyst complex while also regulating essential function of the exocyst complex in transporting proteins out of the cell. Using the simple model animal C. elegans, we successfully identified a separation-of-function missense mutation that disrupts Ral signaling but leaves protein export intact. We will define the biochemical defect in mutant Ral and translate the C. elegans mutation into human Ral proteins in pancreatic ductal adenocarcinoma, in which activation of Ras and Ral are typically very high.

PI_NAMEs: REINER, DAVID  (contact)

PROGRAM_OFFICER_NAME: CERO, CHERYL

PROJECT_TERMS: Anchorage-Independent Growth;Animal Model;Binding;Biochemical;Biological Markers;Caenorhabditis elegans;cancer cell;Carrier Proteins;cell behavior;Cell Line;Cell membrane;Cells;Clinic;Clinical Trials;Complement;Complex;Defect;Development;DNA Sequence Alteration;druggable target;Exocytosis;FDA approved;Genetic;genetic manipulation;Golgi Apparatus;Guanine Nucleotides;Guanosine Triphosphate;Human;In Vitro;in vivo;inhibitor;interest;Invaded;Investigation;Knowledge;KRAS2 gene;Malignant Neoplasms;Mammalian Cell;MEKs;Missense Mutation;Modeling;Molecular;Monomeric GTP-Binding Proteins;Mus;mutant;Mutate;Mutation;novel;novel therapeutic intervention;Oncogenes;Oncogenic;Oncoproteins;Outcome;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;Pathway interactions;pharmacologic;Phenocopy;PIK3CG gene;Pre-Clinical Model;preclinical study;Proliferating;protein complex;Protein Export Pathway;Proteins;Proto-Oncogene Proteins c-akt;ral A GTP-Binding Protein;RALA gene;Regulation;Resistance;Role;Signal Transduction;small molecule inhibitor;Sodium Chloride;Structure;Survival Rate;Testing;Time;Toxic effect;trait;Translating;translational study;tumor;Tumor Suppressor Proteins;tumorigenesis

PROJECT_TITLE: Uncoupling Ral signal transduction from Exocyst functions

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-F (J2)]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Cancer;Genetics;Immunotherapy;Lung

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: NARRATIVE. In this proposal we will determine 1) how clonal cooperation between early (e) and late (L) evolved disseminated cancer cells (DCCs) influences metastasis initiation 2) how eDCCs are immune evasive and 3) how L-DCC and tissue-resident macrophage crosstalk affects DCC reawakening and metastatic growth.

PI_NAMEs: AGUIRRE-GHISO, JULIO A. (contact);BROWN, BRIAN D;SOSA, MARIA

PROGRAM_OFFICER_NAME: GRIL, BRUNILDE M

PROJECT_TERMS: Adopted;Affect;Age;Agonist;Alveolar Macrophages;Alveolus;Anti-Inflammatory Agents;anti-PD-L1 therapy;Bar Codes;Breast;cancer cell;CD8-Positive T-Lymphocytes;Cell Communication;Cell Shape;Cells;Circulation;Clinical;Data;Detection;Development;Disease;Down-Regulation;effective therapy;Excision;FGF2 gene;functional genomics;Galectin 1;Genes;Genetic;genomic platform;Growth;human data;Immune;immune clearance;Immune Evasion;Immune Targeting;Immunity;immunogenic;Immunologic Surveillance;Immunosuppressive Agents;Immunotherapy;Infiltration;Inflammatory;inhibitor;insight;Knowledge;Lung;Macrophage;Maps;Mediating;Metastatic Neoplasm to the Lung;Molecular;Monitor;mouse model;Mutation;Neoplasm Metastasis;Noninfiltrating Intraductal Carcinoma;novel;Operative Surgical Procedures;Organ;Pathway interactions;Patients;Phase;Phenotype;prevent;Primary Neoplasm;Production;Prognosis;programs;Proteins;Recurrence;Relapse;Role;Signal Transduction;single-cell RNA sequencing;specific biomarkers;T-Lymphocyte;targeted treatment;Testing;Time;Tissues;transcription factor;Transforming Growth Factor beta;Transforming Growth Factor Beta 2;tumor;tumor progression;Tumor stage;Work

PROJECT_TITLE: Investigating disseminated cancer cell clonal cooperation and immune control in dormancy and metastasis

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 RTRB-4 (J1)]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Breast Cancer;Cancer;Genetics;Rare Diseases;Women's Health Research

ORG_CITY: KENT

ORG_DEPT: BIOLOGY

ORG_NAME: KENT STATE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative While breast cancer is one of the most common cancers in women in the U.S., ii is extremely rare in men, accounting for less than 1 % of all breast cancer cases. The proposed studies will investigate the mechanism of male breast cancer using a novel transgenic mouse model.

PI_NAMEs: KUROKAWA, MANABU  (contact)

PROJECT_TERMS: Accounting;American;American Cancer Society;Apoptosis;Biological Models;Biology;Carcinogens;Development;Diagnosis;Disease;Duct (organ) structure;Enzymes;Epigenetic Process;ERBB2 gene;Etiology;experimental study;Female;Female Breast Carcinoma;Gene Expression;Goals;Heterozygote;Human;Immunohistochemistry;in vivo;Incidence;Investigation;Label;male;Male mammary gland;Malignant Breast Neoplasm;Malignant neoplasm of liver;Malignant neoplasm of male breast;Malignant Neoplasms;Mammary gland;mammary gland development;Mammary Tumorigenesis;Mass Spectrum Analysis;Mediating;men;Molecular;Mouse Mammary Tumor Virus;mouse model;multicatalytic endopeptidase complex;Mus;Myoepithelial cell;Neurodegenerative Disorders;novel;Oncoproteins;Organ;Pathway interactions;Play;Prevention;Proliferating;protein degradation;Proteins;Proteomics;Quality Control;rare cancer;Regulation;Research;Risk;Role;Secondary to;Signal Pathway;stem cell population;Susceptibility Gene;System;Testing;Tissues;TP53 gene;transcriptome sequencing;Transgenic Mice;tumor;tumorigenesis;Ubiquitin;ubiquitin ligase;Ubiquitin-Activating Enzymes;Ubiquitin-Conjugating Enzymes;ubiquitin-protein ligase;Woman

PROJECT_TITLE: The role of UbcH7 in male breast cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-A (J1)]


NIH_SPENDING_CATS: Aging;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Heart Disease;Physical Activity;Women's Health Research

ORG_CITY: WEST LAFAYETTE

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: PROJECT NARRATIVE Heart failure with preserved ejection fraction (HFpEF) affects disproportionately older women, but very few effective treatments are currently available. The goal of this proposal is to evaluate the benefits of home-based heat therapy (HT) on physical capacity and quality of life in older women with HFpEF. Since this intervention is non-invasive, non-pharmacological and widely accessible, there is high potential for this work to rapidly translate into clinical practice and result in significant improvements in patients’ lives.

PI_NAMEs: HIRAI, DANIEL M. (contact)

PROGRAM_OFFICER_NAME: TINSLEY, EMILY

PROJECT_TERMS: Activities of Daily Living;Affect;Age;Age Years;Arteries;biological sex;Blood capillaries;Blood flow;Blood Pressure;Blood Vessels;Buttocks;cardiovascular health;Cardiovascular system;Chronic;Clinical;clinical practice;Clinical Trials;combat;Controlled Clinical Trials;Coupled;Custom;Data;Diagnosis;disability;Disease;Disease Progression;Double-Blind Method;effective therapy;EFRAC;Elderly;Engineering;Epidemiology;Equation;evidence base;Exercise;exercise capacity;exercise intolerance;Exercise Tolerance;exercise training;exhaustion;experimental study;flexibility;follow-up;Functional disorder;Goals;Growth;Health Expenditures;Heart failure;Heart Rate;Heart Research;Heating;hemodynamics;Hindlimb;Home;Impairment;improved;Individual;innovation;instrument;Intervention;Isotonic Exercise;Leg;Magnetic Resonance Imaging;Magnetic Resonance Spectroscopy;Medicine;men;Microvascular Dysfunction;Mitochondria;mitochondrial dysfunction;Morbidity - disease rate;Morphology;mortality;Muscle;muscle form;Muscle function;Muscle Mitochondria;muscle strength;Near-Infrared Spectroscopy;novel;novel strategies;older women;Outcome;Outcome Study;Patients;Perceived quality of life;Performance;Perfusion;Peripheral;Persons;Physical Capacity;Physical Function;physical impairment;placebo group;portability;Pre-Clinical Model;preservation;Prevalence;primary outcome;Prognosis;Pump;Quality of life;Randomized;Regimen;Research;Respiration;response;Risk Factors;Running;secondary outcome;sex;Skeletal Muscle;skeletal muscle weakness;Supervision;Symptoms;System;targeted treatment;Temperature;Therapeutic;Therapeutic heat application;Thigh structure;Time;Tissues;tool;Translating;Translations;treadmill;Treadmill Tests;treatment response;Tube;United States;Vascular Endothelium;VO2max;Water;Woman;women's diagnosis;Work

PROJECT_TITLE: Heat therapy to improve functional performance in Heart Failure with Preserved Ejection Fraction


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Biomedical Imaging;Eye Disease and Disorders of Vision;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Rare Diseases

ORG_CITY: HOBOKEN

ORG_NAME: THE TRUSTEES OF THE STEVENS INSTITUTE OF TECHNOLOGY

PHR: Project Narrative Deep learning-based diagnosis would provide a consistent diagnosis of retinopathy of prematurity (ROP), especially plus disease, and may improve clinical access to the underserved region via telemedicine. However, the performance of deep learning-based diagnosis is hindered by limited data availability in the training phase of the model and the image quality variations due to different acquisition systems. This study aims to develop a deep learning technology to augment the training dataset using animal-to-human translated images and standardize the image quality for images acquired cross-platforms using multi-task learning.

PI_NAMEs: GAN, YU ;KANG-MIELER, JENNIFER J (contact)

PROGRAM_OFFICER_NAME: GAO, JAMES

PROJECT_TERMS: accurate diagnosis;Address;Age related macular degeneration;animal data;animal imaging;Animal Model;Animal Testing;Animals;Blindness;Blood Vessels;Cellular Phone;Characteristics;Childhood;Classification;Clinical;Clinical Research;Computer Assisted;Data;data platform;data quality;Data Set;deep learning;deep learning model;Dependence;design;Diabetic Retinopathy;Diagnosis;Diagnostic;diagnostic tool;Disease;Exhibits;fundus imaging;generative models;Goals;Human;human data;human imaging;human model;human subject;Image;Image Analysis;image translation;imaging platform;imaging system;improved;Incidence;innovation;interest;International;Label;Learning;Left;longitudinal dataset;Manuals;Methods;Modeling;mouse model;multi-task learning;neural network;Output;Pattern;Performance;Phase;Premature Infant;Process;Quality Control;Rattus;Resources;Retina;retina blood vessel structure;retinal imaging;Retinopathy of Prematurity;Severities;Standardization;success;System;Technology;Telemedicine;Testing;tool;Training;training data;Translating;translational model;Translations;underserved area;usability;Validation;Variant;Vulnerable Populations

PROJECT_TITLE: Deep Learning-based Diagnosis of Retinopathy of Prematurity

STUDY_SECTION: BNVT

STUDY_SECTION_NAME: Bioengineering of Neuroscience, Vision and Low Vision Technologies Study Section[BNVT]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Complementary and Integrative Health;Physical Activity;Physical Injury - Accidents and Adverse Effects;Prevention;Rehabilitation

ORG_CITY: ITHACA

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: CORNELL UNIVERSITY

PHR: Tendinopathies are common musculoskeletal injuries that lead to tendon rupture and disuse. A major hurdle to progress in management of developing chronic tendinopathies is that the mechanism of tendon repair is unknown, largely because it does not naturally occur. The proposed studies will (A) identify biological and mechanical factors that should be considered prior to initiation of conservative treatment such as exercise, (B) determine the therapeutic potential of myofibroblasts and integrin α5, and (C) establish the foundation for new diagnostics and therapeutics to halt the progression of tendon damage and avoid ruptures.

PI_NAMEs: ANDARAWIS-PURI, NELLY  (contact)

PROGRAM_OFFICER_NAME: PINTUCCI, GIUSEPPE

PROJECT_TERMS: Adhesions;antagonist;Apoptosis;Area;Autopsy;Biological;Cell Death;Cell Proliferation;Cell Survival;cell type;Cells;chondroitinase B;Chronic;Clinical;Clinical Data;Collagen;Collagen Fiber;Cytoprotection;Cytoskeleton;Data;Deposition;Dermatan Sulfate;Diagnostic;Disparate;Environment;Exercise;Exercise Therapy;Extracellular Matrix;Fatigue;Fluorescence;Foundations;Gait;Glycosaminoglycans;Hyaluronan;Hyaluronidase;improved;in vivo;in vivo Model;Inhibition of Apoptosis;Injury;Integrin alpha5beta1;Integrins;Investigation;ITGA5 gene;Laceration;Link;mechanical properties;Mechanics;Mediating;Moderate Exercise;Modulus;Morphology;musculoskeletal injury;Myofibroblast;novel diagnostics;novel therapeutics;Outcome;patellar tendon;Pathogenesis;Patients;Peptides;Pharmacologic Substance;Population;Positioning Attribute;prevent;Process;Proliferating;Property;Protocols documentation;Rattus;repaired;response;Role;Running;Rupture;Severities;Simvastatin;single-cell RNA sequencing;Stimulus;Strenuous Exercise;Tendinopathy;Tendon Injuries;tendon rupture;Tendon structure;Testing;Therapeutic;Therapeutic Effect;therapeutic target;Time;tissue repair;Transforming Growth Factor beta;treatment response

PROJECT_TITLE: Promoting a reparative instead of a degenerative outcome from loading of fatigue-damaged tendons

STUDY_SECTION: MTE

STUDY_SECTION_NAME: Musculoskeletal Tissue Engineering Study Section[MTE]


NIH_SPENDING_CATS: Behavioral and Social Science;Caregiving Research;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Pediatric;Prevention;Social Determinants of Health;Suicide;Suicide Prevention

ORG_CITY: PROVIDENCE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: PROJECT NARRATIVE Suicide has become the leading cause of death among adolescents in China, and adolescents in rural China experience particularly high rates of suicidal ideation and attempt while there is a lack of suicide prevention programs for adolescents, teachers, and caregivers in this low-resource, high stigma setting. Building on our team’s prior development and evaluation of a suicide prevention skills-training program for teachers in rural area (“Life Gatekeeper”) and leveraging our relationships with schools and communities in rural Guangdong, the proposed research project will develop and test a multi-level, universal suicide prevention program (“Together We Can”) that aims to address suicide risk, promote mental wellness, reduce stigma and facilitate adolescent help-seeking in this setting by engaging youth, teachers, and caregivers. This research will enhance research capacity for further suicide prevention and adolescent mental health research in rural China.

PI_NAMEs: LIN, DANHUA ;SUN, SHUFANG  (contact)

PROGRAM_OFFICER_NAME: VEDHAM, VIDYA

PROJECT_TERMS: Address;Adolescent;Adolescent Behavior;adolescent mental health;Age;Area;Attitude;bullying;Caregivers;Cause of Death;Cellular Phone;China;Chinese;Chronic;Clinical;Communities;community advisory board;community partners;community-centered;Competence;coping;cost;Data;depressive symptoms;deprivation;design;Development;Education;Educational Curriculum;Educational process of instructing;Educational workshop;effectiveness testing;Evaluation;evidence base;experience;Exploration, Preparation, Implementation, and Sustainment;Exposure to;Family;Feeling suicidal;flexibility;Focus Groups;Foundations;Future;Gatekeeping;Goals;Grant;Health behavior;health literacy;help-seeking behavior;high risk;Hospitals;implementation facilitators;implementation framework;implementation strategy;improved;Income;Individual;Intervention;intervention delivery;intervention program;Intervention Studies;Interview;Investments;Life;literacy;Lived experience;low and middle-income countries;Manuals;Mediating;member;Mental Health;Meta-Analysis;mHealth;mobile computing;Modality;Outcome;peer;Phase;Pilot Projects;Population;Poverty;Preparation;Prevalence;Prevention program;preventive intervention;primary outcome;programs;Protocols documentation;Psychiatry;psychologic;Public Health;public health emergency;public health priorities;Randomized, Controlled Trials;Research;Research Personnel;Research Project Grants;Resources;Risk;Role;Running;Rural;rural area;Safety;School Teachers;Schools;secondary outcome;Self Efficacy;Severities;Shapes;skills;skills training;social emotional learning;social stigma;Solid;Stigmatization;Students;successful intervention;suicidal adolescent;suicidal behavior;suicidal risk;Suicide;Suicide attempt;Suicide prevention;suicide rate;Surveys;System;teacher;Teacher Professional Development;Technology;Testing;Training;Training Programs;treatment as usual;universal prevention;Universities;Well in self;willingness;Work;Youth

PROJECT_TITLE: Engaging Youth, Caregivers, and Teachers for Suicide Prevention:  Developing and Implementing a Multi-Level Intervention in Rural China

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-C (01)]


NIH_SPENDING_CATS: Aging;Cancer;Colorectal Cancer;Complementary and Integrative Health;Digestive Diseases;Genetics;Prevention

ORG_DEPT: NUTRITION

PHR: The objective of this application is to investigate anticancer effect and mechanism of promising cancer-preventive agents in an innovative model that resembles high-risk colorectal cancer. The success of our study will generate critical efficacy data that are needed for supporting future funding applications to further develop these promising anticancer agents. Our project will likely help develop new preventive agents that potentially decrease cancer mortality and is important for translation of basic research to the clinic.

PI_NAMEs: JIANG, QING  (contact)

PROGRAM_OFFICER_NAME: KUMAR, AMIT

PROJECT_TERMS: adenoma;Adult;Agreement;Alleles;anti-cancer;Anti-Inflammatory Agents;anticancer activity;Antineoplastic Agents;APC gene;Arachidonate 5-Lipoxygenase;Aspirin;Azoxymethane;Basic Science;beta catenin;Cancer Cell Growth;Cancer Etiology;Cancer Model;Cessation of life;Chemicals;Clinic;clinically relevant;Colitis associated colorectal cancer;Colon;colon cancer patients;Colon Carcinoma;Colonoscopy;Colorectal Cancer;colorectal cancer prevention;colorectal cancer risk;conditional knockout;cyclooxygenase 1;Cyclooxygenase Inhibitors;Data;delta tocotrienol;Development;dextran sulfate sodium induced colitis;DNA Sequence Alteration;driver mutation;Early Diagnosis;effective therapy;Effectiveness;Eicosanoids;Engineering;Enterobacteria phage P1 Cre recombinase;Epithelium;Family;frailty;Funding;Future;Garcinia kola;Gene Expression;Genes;Genetic Predisposition to Disease;Goals;high risk;high risk population;Human;improved;Inflammation;Inflammatory;innovation;Investigation;Knowledge;KRAS2 gene;Large Intestine;life span;Location;Malignant Neoplasms;MAP Kinase Gene;Mediating;member;Modeling;Molecular Target;mortality;mouse model;Mus;mutant;Non-Steroidal Anti-Inflammatory Agents;novel;Nuclear;Oncogenes;Pathway interactions;Persons;Pharmaceutical Preparations;Phase;PI3K/AKT;pre-clinical;preclinical study;prevent;Prevention strategy;Preventive;Prostaglandin-Endoperoxide Synthase;Recommendation;Reporting;Research;Role;side effect;Signal Transduction;Small Intestines;STAT3 gene;success;Testing;Tocotrienols;transcriptome sequencing;Translations;tumor;tumor progression;Vitamin E

PROJECT_TITLE: Anti-cancer effects of tocotrienols and a carboxychromanol in an innovative colon cancer model

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 RTRB-Z (J1)]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Biotechnology;Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Genetics;Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_DEPT: NEUROLOGY

PHR: Project Narrative Neurodegenerative diseases are imposing an increasing health and financial burden given the rapid increase of the aging segment of the population. This grant will use a multidisciplinary approach to characterize PAS kinase as a new novel target for therapy of spinocerebellar ataxias, amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Our approaches will likely have a broad impact on other neurodegenerative diseases as well.

PI_NAMEs: SCOLES, DANIEL R (contact)

PROGRAM_OFFICER_NAME: GUBITZ, AMELIE

PROJECT_TERMS: age related;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Amyotrophic Lateral Sclerosis;Attention;Autophagocytosis;CAG repeat;CASP3 gene;Cells;Cerebellum;Cultured Cells;Data;Dementia;detection of nutrient;Development;Disease;Effectiveness;Encephalopathies;expectation;Financial Hardship;FRAP1 gene;Frontotemporal Dementia;frontotemporal lobar dementia amyotrophic lateral sclerosis;Future;Gait;Gel;Genes;Genetic;Grant;Health;Homologous Gene;Human;human induced pluripotent stem cells;improved;in vivo;induced pluripotent stem cell;Induced pluripotent stem cell derived neurons;inhibitor;interdisciplinary approach;kinase inhibitor;knock-down;Knockout Mice;MALDI-TOF Mass Spectrometry;Malignant Neoplasms;Mass Spectrum Analysis;Messenger RNA;Modification;Molecular;molecular phenotype;Motor;motor behavior;mouse model;Mus;mutant;Mutate;Mutation;Nerve Degeneration;Neurodegenerative Disorders;Neurons;new therapeutic target;Nutrient;Pathology;Pathway interactions;Patients;Phenotype;phosphatidylinositol 3'-kinase-associated serine kinase;Phosphorylated Peptide;Phosphorylation;Phosphotransferases;polyglutamine;Population;Post-Translational Protein Processing;protein biomarkers;protein TDP-43;Proteins;Proteomics;PrP;Purkinje Cells;Regulation;Regulatory Pathway;Resources;RNA Interference;Role;sensor;Signal Pathway;Signal Transduction;Site;Spinal Cord;Spinocerebellar Ataxias;stress granule;targeted treatment;Testing;Therapeutic;therapeutic development;therapeutic target;Transcript;transcriptome;Transgenic Mice;Translations;Type 2 Spinocerebellar Ataxia;Western Blotting;Work;Yeasts

PROJECT_TITLE: PASK-regulated genes and proteins as therapeutic targets for ALS and FTD

STUDY_SECTION: CDIN

STUDY_SECTION_NAME: Chronic Dysfunction and Integrative Neurodegeneration Study Section[CDIN]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Contraception/Reproduction;Infertility;Pregnancy;Prevention;Women's Health Research

ORG_CITY: STANFORD

ORG_DEPT: UROLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE As up to 15% couples are infertile, further examination of the intersection of reproductive and somatic health has implications for millions of individuals around the world. By examining two prospective preconception cohorts with populations in three countries, there is an opportunity to shed insight on future health risk for infertile males and females, which could be modified by early recognition.

PI_NAMEs: EISENBERG, MICHAEL L (contact);SØRENSEN, HENRIK TOFT;WISE, LAUREN A

PROGRAM_OFFICER_NAME: TAYMANS, SUSAN

PROJECT_TERMS: Affect;Area;Autoimmune Diseases;Biological Markers;Body mass index;Canada;cancer risk;Cardiometabolic Disease;cardiometabolic risk;Cardiovascular Diseases;Caring;Characteristics;Clinical;Clinical Data;cohort;Collection;Conceptions;Country;Couples;Data;Denmark;Diagnosis;Disease;disorder prevention;Early Intervention;early pregnancy loss;Education;Enrollment;ethnic diversity;Ethnic Origin;Etiology;Evaluation;Female;Fertility;fitness;follow-up;Future;Geography;Gravid;Health;Heart Diseases;Hyperlipidemia;Hypertension;Immune System Diseases;Impairment;improved;Incidence;Income;Individual;Infertility;infertility treatment;insight;Internet;Investigation;Literature;male;Measurement;Medical Records;member;middle age;Modeling;mortality;Names;National Institute of Child Health and Human Development;Non-Insulin-Dependent Diabetes Mellitus;North America;Occupations;Outcome;ovarian reserve;Parents;parity;Participant;participant enrollment;Pathway interactions;perinatal period;Population;Population Heterogeneity;post pregnancy;Pregnancy;Pregnancy loss;pregnant;Prevention;Primary Prevention;programs;prospective;Prospective cohort;Prospective Studies;Prospective, cohort study;Questionnaires;Race;racial diversity;Recontacts;Recording of previous events;Registries;reproductive;reproductive function;Research Design;Rheumatoid Arthritis;Risk;Seminal fluid;Smoking;Subfecundity;Systemic Lupus Erythematosus;Thyroiditis;time-to-pregnancy;Translating;trying to conceive;Validation;Weight Gain;Women's cohort;Work

PROJECT_TITLE: Impaired fecundity and future health: a prospective investigation of pregnancy planners in North America and Denmark

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 EMS-J (55)]


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Cancer;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Depression;Health Services;Mental Health;Mental Illness;Palliative Care

ORG_CITY: EAST LANSING

ORG_NAME: HENRY FORD HEALTH + MICHIGAN STATE UNIVERSITY HEALTH SCIENCES

ORG_STATE: MI

PHR: Friend and family caregivers of recently deceased cancer patients experience acute bereavement following the death. Post death bereavement is an intense period of mourning that includes an unfolding of the grief process and is characterized by strong emotions and demands on cognitive resources to those who have put aside their own needs to support the dying patient with cancer. This research will test the feasibility and acceptability of a nature-based healing meditation (NBHM) intervention to support cancer caregivers’ during the bereavement process.

PI_NAMEs: LEHTO, REBECCA H (contact)

PROGRAM_OFFICER_NAME: STRECK, BRENNAN PARMELEE

PROJECT_TERMS: acceptability and feasibility;Acute;Address;Advanced Malignant Neoplasm;Affect;Anxiety;anxiety reduction;anxiety symptoms;Area;Auditory;Awareness;Bereavement;Bereavement Care;Buffers;Cancer Death Rates;Cancer Intervention;Cancer Patient;caregiver interventions;Caregivers;Caring;Cessation of life;Cognitive;cognitive capacity;Communities;Consent;cost effective;Data;depressive symptoms;Development;directed attention;Discipline of Nursing;Disease;DSM-V;Early Intervention;effective intervention;Effectiveness;efficacy testing;Eligibility Determination;emotion regulation;Emotional;emotional distress;Emotions;end of life care;Enrollment;experience;Exposure to;Family Caregiver;feasibility testing;Feeling;flexibility;Friends;Generations;Goals;Grief reaction;Growth;healing;Health;Heart Rate;Home;Hospice Care;hospice environment;Hour;Hydrocortisone;improved;Individual;informal support;Intervention;Intervention Studies;Interview;Learning;Letters;Long-Term Effects;Longitudinal Studies;Malignant Neoplasms;Measures;Medical;Meditation;meetings;Mental Depression;Mental Health;Methods;Michigan;Mind;Modeling;Mourning;Muscle relaxation phase;National Cancer Institute;Nature;online delivery;Patient Care;Patient Preferences;Patients;Personal Satisfaction;Persons;physical conditioning;Pilot Projects;pilot test;post intervention;Prefrontal Cortex;Process;programs;Quality of life;Randomized, Controlled Trials;Recovery;recruit;Relaxation;Research;Resources;response;Rest;Role;rumination;Sampling;satisfaction;Services;Site;skills;statistics;Structure;Suggestion;Targeted Research;Testing;Time;Training;trial comparing;United States National Institutes of Health;user-friendly;web site;Well in self;Work

PROJECT_TITLE: Support for bereaved friend and family caregivers of cancer patients

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-2 (J2)]


NIH_SPENDING_CATS: Back Pain;Behavioral and Social Science;Chronic Pain;Neurosciences;Pain Research

ORG_CITY: TEMPE

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

ORG_STATE: AZ

PHR: PROJECT NARRATIVE Chronic low back pain is a leading cause of chronic pain and has a substantial economic impact in the United States. Treatments for disc-associated low back pain exhibit poor long-term efficacy highlighting an important unmet medical need. Our work will develop a novel model of chronic low back pain that sufficiently mimics human patients, to more accurately screen therapeutics for treatment.

PI_NAMEs: KING, TAMARA E;WACHS, REBECCA ANN (contact)

PROGRAM_OFFICER_NAME: CONRAD, CHRISTOPHER GARNER

PROJECT_TERMS: Address;Adopted;Animal Model;Animals;Anti-Inflammatory Agents;Automobile Driving;Back Pain;Behavior;behavior measurement;Behavioral;behavioral outcome;Biological;Biological Assay;Blood Vessels;Cells;Characteristics;Chronic;Chronic low back pain;chronic pain;Clinical;Cohort Studies;conditioned place preference;cost;Development;discogenic pain;economic impact;Ensure;Etiology;Exhibits;Face;Failure;Frequencies;Goals;Growth;Hand Strength;Height;Histologic;Human;human data;human disease;Hypersensitivity;improved;Inflammation;Inflammatory;injured;Injury;Institution;intervertebral disk degeneration;Knowledge;Laboratories;Low Back Pain;Magnetic Resonance Imaging;Measures;Medical;Mental Depression;Methods;Modeling;Monitor;Movement;Musculoskeletal Pain;Nerve;nerve supply;Neurosciences;novel;novel therapeutics;Operative Surgical Procedures;Orthopedics;Outcome;Outcome Measure;Pain;pain behavior;Pain management;Pathologic;Pathology;Patients;Pharmaceutical Preparations;Phase;Phenotype;Physiological;pre-clinical;Pre-Clinical Model;Publishing;Puncture procedure;Rattus;Reproducibility;Reproduction;Resolution;response;Risk;Roentgen Rays;Screening procedure;sex;Sleeplessness;Specificity;Speed;spontaneous pain;Suicide;Sum;Surgeon;Testing;Therapeutic;Time;tomography;Training;translational model;translational potential;Unemployment;United States;Validation;Water;Work

PROJECT_TITLE: Validation of a Translational Model of Chronic Discogenic Low Back Pain

STUDY_SECTION: NSD

STUDY_SECTION_NAME: Neurological Sciences and Disorders A Study Section[NSD-A]


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Genetics;Lupus;Women's Health Research

ORG_CITY: DUARTE

ORG_NAME: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE

PHR: PROJECT NARRATIVE Abnormal autoantibody-producing B-cell subsets, including plasma cells, are a major driver of systemic lupus erythematosus (SLE). Specific eradication of pathogenic B cells in SLE poses significant clinical challenges. Our proposed experiments will solidify blocking the synthesis of the long isoform of the prolactin receptor (LFPRLR) as an effective approach to specifically eradicate abnormal plasma cells and their precursors without affecting their normal counterparts in patients with SLE.

PI_NAMEs: SWAMINATHAN, SRIVIDYA  (contact)

PROGRAM_OFFICER_NAME: MANCINI, MARIE

PROJECT_TERMS: Adult;Affect;Age;Alternative Splicing;Amino Acids;Anti-Inflammatory Agents;Apoptotic;Autoantibodies;autocrine;Autoimmune;Autoimmune Diseases;autoreactive B cell;autoreactivity;B-Lymphocyte Subsets;B-Lymphocytes;Biological Assay;Body System;Bortezomib;Brain;CD19 gene;Cell Proliferation;Cell Survival;Cells;Child;Childhood;chronic autoimmune disease;Clinical;clinical development;Data;Development;differentiation in vitro;Disease;Disease remission;DNA;Dopamine Agonists;Environmental Risk Factor;Enzyme-Linked Immunosorbent Assay;Estrogens;experimental study;Female;Flow Cytometry;Frequencies;Genetic;girls;Heart;high dimensionality;Histones;Hormonal;Hormones;Human;Hyperactivity;Immune;Immune system;immunodeficiency;Immunoglobulin Class Switching;Immunoglobulins;immunoregulation;In Vitro;in vivo;Incidence;Induction of Apoptosis;Inflammation;Joints;Kidney;knock-down;Legal patent;Leukocytes;Lung;male;Measurement;Measures;Messenger RNA;mouse model;Mus;neurotoxicity;novel;Outcome;paracrine;Pathogenicity;Pathologic;Pathology;Patients;Peripheral Blood Mononuclear Cell;Phenotype;Pituitary Gland;plasma cell differentiation;Plasma Cells;Plasmablast;preclinical development;prevent;PRLR gene;Production;Prolactin;Prolactin Receptor;Proliferating;Proteasome Inhibitor;Protein Isoforms;Proteins;Proteinuria;Publishing;receptor;reduce symptoms;Regimen;Research;RNA;RNA Splicing;Sampling;side effect;Signal Transduction;single-cell RNA sequencing;Site;Skin;Splenocyte;Structure of germinal center of lymph node;Symptoms;Systemic Lupus Erythematosus;targeted treatment;Testing;Therapeutic;therapeutic target;Tissues;Transplantation;Woman;women versus men

PROJECT_TITLE: Concurrent eradication of pathogenic plasma cells and their precursors in systemic lupus erythematosus


NIH_SPENDING_CATS: Antimicrobial Resistance;Biotechnology;Genetics;Human Genome;Infectious Diseases

ORG_CITY: UNIVERSITY PARK

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

ORG_STATE: PA

PHR: Insertion sequences are small, mobile DNA elements residing in many bacterial genomes whose activation leads to subpopulations with amplified segments of the chromosome. The increased gene copy number creates heterogeneous cells with distinct phenotypes which improves odds of surviving environmental challenges, including nutrient stress and exposure to antibiotics. This project aims to understand host bacterial factors and environmental conditions that regulate insertion sequence activation and the generation of cell individuality.

PI_NAMEs: MEREDITH, TIMOTHY C. (contact)

PROGRAM_OFFICER_NAME: MACARTHUR, LINDA

PROJECT_TERMS: Address;Antibiotic Therapy;Antibiotics;antimicrobial;Bacteria;Bacterial Chromosomes;Bacterial Genome;Bacterial Model;bacterial resistance;Base Pairing;Biological Assay;Biological Models;Cells;Chromosomal Duplication;Chromosomes;Complex;Cues;Data;Distant;DNA;DNA amplification;DNA Insertion Elements;Drug Targeting;Elements;Ensure;Environmental Risk Factor;Escherichia coli;Event;Exposure to;Family;Flow Cytometry;Frequencies;Gene Amplification;Gene Dosage;Gene Expression;Gene Expression Profile;gene function;Generations;Genes;Genetic;Genetic Recombination;Genetic Transcription;Genome;Genomic DNA;Genomic Segment;Genomics;Goals;Head;Heterogeneity;Hybrids;improved;Individuality;insight;Integration Host Factors;Intermediate resistance;Inverted Terminal Repeat;IS Elements;Label;Lipopolysaccharides;Measures;Mediating;Modeling;Modernization;Mutation;Noise;Nutrient;Operon;Phenotype;Plasmids;Play;Point Mutation;Polymyxin B;Polymyxin B resistance;Population;Population Heterogeneity;pressure;prevent;Process;Production;promoter;Regulation;Reporting;resistance frequency;Resolution;Role;Sampling;Series;Shapes;Site;Stress;System;Tail;Tandem Repeat Sequences;Testing;tool;Transposase;transposon sequencing;transposon/insertion element;Variant

PROJECT_TITLE: Contribution of insertion sequence mediated tandem chromosomal amplification to bacterial heterogeneity

STUDY_SECTION: PCMB

STUDY_SECTION_NAME: Prokaryotic Cell and Molecular Biology Study Section[PCMB]


ORG_CITY: AMHERST

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

ORG_STATE: NY

PHR: PROJECT NARRATIVE Activating the compensatory signaling pathway for survival is expected in cancers, especially prostate cancer. We have learned that inhibition of AR can induce GR expression and activity to evade AR blockade. Currently, clinical trials are testing the therapeutic effects of AR-targeted therapies with GR modulators (NCT03674814) in CRPC. This proposal will study GR-driven lethal prostate cancers' complexities, mechanisms, and vulnerabilities across advanced disease stages.

PI_NAMEs: ADELAIYE-OGALA, REMI  (contact)

PROGRAM_OFFICER_NAME: GREENBERG, WILLIAM A

PROJECT_TERMS: acquired treatment resistance;advanced disease;advanced prostate cancer;AKT inhibition;AKT1 gene;androgen deprivation therapy;androgen independent prostate cancer;Androgen Receptor;androgen sensitive;antagonist;antitumor effect;Binding;Biological Assay;Biological Markers;cancer cell;Castrate sensitive prostate cancer;Cell Death;Cell Nucleus;Cell Proliferation;Cell Survival;Cells;Cellular Morphology;ChIP-seq;Chromatin;chromatin protein;Clinical Research;Clinical Trials;clinically relevant;CRISPR/Cas technology;Data;Disease;Disease Progression;Disease Resistance;DNA;Drug resistance;efficacy evaluation;enzalutamide;experimental study;Exposure to;Glucocorticoid Receptor;glucocorticoid-induced orphan receptor;Hormone Receptor;Immunoprecipitation;Inhibition of Cell Proliferation;inhibitor;interest;knock-down;Knock-out;Knowledge;Learning;Ligands;Malignant neoplasm of prostate;Malignant Neoplasms;Mediating;Modeling;multiple omics;Mutation;novel therapeutic intervention;Nuclear Hormone Receptors;Oncogenic;patient derived xenograft model;Patients;pharmacologic;Phosphorylation;Phosphorylation Inhibition;Physicians;Play;Post-Translational Protein Processing;preclinical study;prostate cancer cell line;Proteomics;Proto-Oncogene Proteins c-akt;Publishing;receptor;receptor expression;Receptor Signaling;Resistance;Resolution;response;Role;Scientist;Serine;Signal Pathway;Signal Transduction;targeted treatment;Testing;Therapeutic;Therapeutic Effect;therapeutic evaluation;therapy resistant;transcriptomics;Treatment Efficacy;tumor

PROJECT_TITLE: Posttranslational modifications of glucocorticoid receptor associated with drug-resistance in prostate cancer

STUDY_SECTION: MCTB

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics B Study Section[MCTB]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Genetics;Nutrition;Women's Health Research

ORG_CITY: TAMPA

ORG_NAME: H. LEE MOFFITT CANCER CTR & RES INST

ORG_STATE: FL

PHR: Narrative This proposal attempts to unravel a major challenge in understanding cancer progression i.e., how microenvironmental stress in the primary tumor select for distinct metabolic phenotypes. Specifically, we will study how switching to a lipogenic phenotype confers metabolic advantage to stress adapted cells. We propose to decipher the relationship between microenvironmental stress-induced evolution that results in hardwired phenotypic adaptation represented by a lipogenic phenotype as an initiator of cancer progression.

PI_NAMEs: PILLAI, SMITHA R (contact)

PROJECT_TERMS: Acidity;Acidosis;Acids;Acute;Adopted;Amino Acids;Anabolism;Attention;Autophagocytosis;Benign;Biological Assay;Blood Vessels;Breast Cancer Cell;Cancer Biology;cancer cell;cancer type;carcinogenesis;cell injury;Cell membrane;Cell Survival;Cells;Chronic;Clone Cells;Common Neoplasm;comparison control;Consumption;Coupled;Cytoplasm;cytotoxicity;Data;Dependence;deprivation;Disease Progression;Disseminated Malignant Neoplasm;Duct (organ) structure;Ecosystem;Energy-Generating Resources;Epigenetic Process;Event;Evolution;Exhibits;experimental study;extracellular;fatty acid oxidation;flexibility;Future;Gene Expression;Gene Expression Profile;Genetic Heterogeneity;Genotype;Genus Hippocampus;Glucose;Growth;Heritability;Hyperplasia;Hypoxia;Image;Immunologic Surveillance;In Vitro;Indolent;Invaded;ketogentic;lipid biosynthesis;Lipids;lysosomal proteins;Lysosomes;Malignant - descriptor;Malignant Breast Neoplasm;Malignant Neoplasms;MCF7 cell;Measures;Mediating;Metabolic;Metabolic Pathway;metabolic phenotype;Metabolism;Microscopy;migration;Milk;Modeling;Mutation;Neoplasm Metastasis;neoplastic cell;new therapeutic target;Normal tissue morphology;novel therapeutics;Nutrient;nutrient deprivation;Oxygen Consumption;Pathway interactions;Patients;Perfusion;Phenotype;premalignant;pressure;Primary Neoplasm;Process;Production;Protons;receptor;receptor mediated endocytosis;Recycling;Reporting;Resistance;Role;Route;Signal Transduction;small hairpin RNA;Source;spatiotemporal;stable isotope;Starvation;Stress;stressor;Stromal Cells;Testing;TFE3 gene;Tissue-Specific Gene Expression;Tracer;transcription factor;transcriptome sequencing;tumor;tumor behavior;tumor microenvironment;tumor progression;Variant;Xenograft Model

PROJECT_TITLE: Investigating lipid phenotype as a metabolic adaptation to microenvironmental stress

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 TCRB-J (J2)]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Digestive Diseases;Genetics;Liver Disease;Neurosciences;Rare Diseases

ORG_CITY: ORANGE

ORG_NAME: CHAPMAN UNIVERSITY

ORG_STATE: CA

PHR: NARRATIVE  There are seven human genetic mutations of KCa2.3 linked to Zimmermann-Laband syndrome 3 (ZLS3) and one mutation associated with idiopathic noncirrhotic portal hypertension (INCPH). We hypothesize that ZLS3 is related to abnormally elevated Ca2+ sensitivity of the mutant KCa2.3 channels. We will explore FDA-approved drugs and compounds in clinical trials that inhibit KCa2.3 channels as candidates for off-label or compassionate use.

PI_NAMEs: ZHANG, MIAO  (contact)

PROGRAM_OFFICER_NAME: MATOS GALICIA, HEIDI YANICE

PROJECT_TERMS: Affect;biophysical analysis;Biophysics;boys;Calmodulin;casein kinase II;Clinical Trials;Complex;Computer Models;design;Developmental Delay Disorders;developmental disease;developmental genetics;Diagnosis;digital;Disease;Distal;DNA Sequence Alteration;Docking;Ear;Endothelial Cells;extracellular;Face;FDA approved;Fingers;Gingiva;Hearing;Homology Modeling;Human;Human Genetics;Hypersensitivity;in silico;inhibitor;Intellectual functioning disability;Ion Channel;Laband syndrome;Label;Link;Measures;Membrane;Molecular Conformation;multidisciplinary;mutant;Mutation;Nose;Paper;patch clamp;Patients;Pharmaceutical Preparations;Phenylalanine;Phosphorylation;Physicians;Portal Hypertension;Positioning Attribute;Proteins;PubMed;Reporting;Research;Research Personnel;response;Salmon;simulation;Site-Directed Mutagenesis;Structure;Structure of nail of finger;Testing;theories;United States National Institutes of Health;Valine

PROJECT_TITLE: Channelopathy of KCa2.3 and Zimmermann-Laband syndrome

STUDY_SECTION_NAME: Biochemistry and Biophysics of Membranes Study Section[BBM]


NIH_SPENDING_CATS: Genetics;Hematology;Primary Immunodeficiencies;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

PHR: Isolation and processing hematopoietic stem cells (HSC) in the hypoxia condition strikingly improve numbers and functionalities of HSCs. Here, we propose to study the functions of p38 MAPK/Nrf2/Bach1 pathway in the hypoxia condition in the context of Fanc-/- HSCs. We will also develop a Spacer-Nick gene correction system along with inhibition of p38 pathway to restore the functions of Fanc-/- HSCs.

PI_NAMEs: KAPUR, REUBEN  (contact);TRAN, NGOC TUNG

PROGRAM_OFFICER_NAME: HATTANGADI, SHILPA MANOHAR

PROJECT_TERMS: Air;Antioxidants;BACH1 gene;BIM Bcl-2-binding protein;biological adaptation to stress;Bone Marrow;Bone marrow failure;Budgets;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;cofactor;Collecting Cell;correctional system;Data;differential expression;Disease;DNA Damage;DNA Double Strand Break;Engraftment;Exposure to;Fanconi's Anemia;functional restoration;gene correction;gene network;gene therapy;Genes;genetic approach;Harvest;hematopoietic differentiation;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;Human;Hypoxia;improved;In Vitro;in vivo;Inflammatory;innate immune pathways;long term recovery;Malignant - descriptor;Malignant Neoplasms;MAP Kinase Gene;MAPK8 gene;Mediating;Molecular;Mus;Mutation;Non-Malignant;normoxia;novel;Oxidative Stress;Oxygen;p38 Mitogen Activated Protein Kinase;Pathway interactions;Patients;Phenotype;Physiological;pro-apoptotic protein;Process;programs;rare genetic disorder;Reactive Oxygen Species;Recommendation;Recovery;Reporting;Repression;response;restoration;Role;self renewing cell;self-renewal;Shock;Source;stem cell function;stem cell genes;Stress;Techniques;Text;transcription factor;Transplantation;transplantation therapy;Umbilical Cord Blood;Up-Regulation;Work

PROJECT_TITLE: Hypoxia's role in regulating stressed hematopoietic stem cells

STUDY_SECTION_NAME: Basic Biology of Blood, Heart and Vasculature Study Section [BBHV]


NIH_SPENDING_CATS: Autoimmune Disease;Celiac Disease;Clinical Research;Digestive Diseases;Microbiome;Prevention

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Potential celiac disease occurs when an antibody blood test for celiac disease is positive, but the small intestinal biopsy is normal. Some of these patients will progress to biopsy-positive celiac disease, while others do not. We will determine the difference in immune system signals, active genes in the small intestine, and small intestinal and stool microbial communities in children with celiac disease, potential celiac disease, and non-celiac disease controls to understand the changes that occur which allow loss of gluten tolerance and tissue injury.

PI_NAMEs: HOLTZ, LORI R (contact)

PROGRAM_OFFICER_NAME: HUDSPETH, KELLY

PROJECT_TERMS: 16S ribosomal RNA sequencing;adaptive immune response;Adaptive Immune System;Adherence;Adult;Affect;Age;Alabama;Alleles;Antibodies;Antigens;Architecture;aspirate;bacteriome;Biopsy;Biopsy Specimen;Blood;Blood Tests;Case Management;CD4 Positive T Lymphocytes;CD8 receptor;CD8-Positive T-Lymphocytes;Celiac Disease;Cells;Child;Clinical;Consumption;Data;Development;Diagnosis;Diet;Disease;Disease Marker;Disease Progression;disorder control;Duodenum;Endomysium;Endoscopy;Environmental Risk Factor;Event;Evolution;fecal microbiome;Feces;Frequencies;gene environment interaction;Genes;Genetic Predisposition to Disease;Genetic Transcription;Gliadin;Gluten;gut homeostasis;Haplotypes;Histologic;Histology;HLA-DQ2;HLA-DQ8 antigen;Immune;Immune response;Immune system;Immunoglobulins;Immunologics;immunoregulation;Individual;Inflammation;Inflammatory;Infrastructure;Injury;Innate Immune Response;insight;Integration Host Factors;intestinal barrier;Intestines;Killer Cells;Knowledge;Learning;Liquid substance;Location;Measures;Mediating;Metadata;metagenomic sequencing;microbial;microbial community;microbiome;microbiota;Mucous Membrane;Newly Diagnosed;novel;Participant;Pathogenesis;Pathogenicity;Pathology;Patients;Peptide Initiation Factors;Peripheral Blood Mononuclear Cell;Persons;Plasma;Population;Populations at Risk;Predisposition;Prevalence;prevent;Process;Progressive Disease;prospective;Prospective cohort;Prospective, cohort study;Quality of life;Race;receptor;recruit;Reporting;response;risk variant;Role;Sampling;serological marker;Serology;seropositive;sex;Signal Transduction;Small Intestines;Symptoms;T cell clonality;Time;tissue injury;Tissue Transglutaminase Antibodies;Tissues;transcriptomics;Universities;Villous;Viral;virome;Washington;Work

PROJECT_TITLE: Microbial and Host Factors in the Progression to Celiac Disease

STUDY_SECTION: DHMI

STUDY_SECTION_NAME: Digestive System Host Defense, Microbial Interactions and Immune and Inflammatory Disease Study Section[DHMI]