ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative This application aims to establish a biomarker characterization center to identify biomarkers in clinically easily accessible samples and to develop them into clinical tests to capture high-grade serous ovarian carcinoma (the most common and deadliest form of ovarian cancer) at the early stages when surgical and therapeutic treatment may still be able to change a patient’s long-term survival. The initial development and testing will be in high-risk women population.

PI_NAMEs: SHIH, IE-MING ;ZHANG, ZHEN  (contact)

PROGRAM_OFFICER_NAME: PATRIOTIS, CHRISTOS F

PROJECT_TERMS: Abate;assay development;Bioinformatics;Biological;Biological Assay;Biological Markers;Biology;biomarker development;biomarker discovery;biomarker evaluation;biomarker identification;biomarker validation;Biomedical Engineering;Biometry;Blood specimen;brca gene;Cancer Biology;Cancer Patient;candidate marker;candidate validation;Carcinoma in Situ;Chromosomal Instability;Clinical;Clinical Chemistry;Communities;Data;Data Science;design;Developed Countries;Development;Disease;disease diagnosis;early detection biomarkers;Early Detection Research Network;Early Diagnosis;Ensure;Epithelial ovarian cancer;Epithelium;experience;Frequencies;Funding;Future;General Population;Generations;Genes;genome-wide;Genomics;Goals;high risk;High Risk Woman;Histologic;homologous recombination;improved;in-vitro diagnostics;Incidence;indexing;innovation;Knowledge;Level of Evidence;Low Prevalence;Malignant neoplasm of ovary;Malignant Neoplasms;Mammalian Oviducts;Mass Spectrum Analysis;member;Mission;Molecular;multidisciplinary;Mutation;novel;Operative Surgical Procedures;Ovarian;Ovarian Serous Adenocarcinoma;Ovary;Pap smear;Pathogenesis;Pathology;Pathway interactions;Patients;Performance;Peritoneal;Population;Process;process optimization;programs;Recurrence;Research;Research Personnel;Resources;Risk;sample collection;Sample Size;Sampling;screening;Screening for Ovarian Cancer;Serous;sound;Specificity;Specimen;Specimen Handling;study population;success;Technology;Testing;Therapeutic;Tissues;tool;TP53 gene;Translating;Woman;Work

PROJECT_TITLE: A multidisciplinary BCC for ovarian cancer early detection: translating discoveries to clinical use with a by-design approach


ADMINISTERING_IC: CA

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Prevention

ORG_CITY: KANSAS CITY

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PI_NAMEs: TOREN , PAUL  (contact)

PROJECT_TERMS: analytical method;anti-cancer research;anti-cancer therapeutic;Antineoplastic Agents;Applications Grants;Biochemical;Biological Markers;Biometry;Cancer Center;cancer prevention;Clinic;clinical application;Clinical Pharmacology;Clinical Research;clinical trial protocol;Clinical Trials;clinically relevant;Collaborations;Computer software;cost;Data;Data Analyses;Data Reporting;design;Development;Discipline;Disease;Dose;Drug Exposure;Drug Kinetics;Ensure;Experimental Designs;FDA approved;Funding;Goals;Growth;Holidays;Hour;Human Resources;indicated prevention;informatics shared resource;instrumentation;investigator-initiated trial;Kansas;Laboratories;laboratory manuals;Life Cycle Stages;Malignant Neoplasms;Manuals;member;Methods;Modeling;Patient Participation;Patients;Pharmaceutical Preparations;Pharmacodynamics;pharmacokinetics and pharmacodynamics;Pharmacology Shared Resource;Play;Population;population health;Population Study;Postdoctoral Fellow;Preparation;Prevention;Process;Productivity;programs;protein biomarkers;Protocols documentation;Publications;Reporting;Research;Research Personnel;response;Role;Sampling;Scheme;Scientist;Services;Shipping;Site;Technology;theories;Therapeutic;therapeutic development;Time;Training;translational study;Universities;Work;working group

PROJECT_TITLE: Clinical Pharmacology Shared Resource

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


ADMINISTERING_IC: DC

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Assistive Technology;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Neurosciences;Rehabilitation

ORG_DEPT: BIOMEDICAL ENGINEERING

PHR: PROJECT NARRATIVE The vestibular system located in the inner ear senses the motion of the head, and vestibular loss is a debilitating condition that leads to problems with vision, gait, and balance. A notable recent development is the multichannel vestibular prosthesis, a neural implant that aims to replace the function of damaged vestibular peripheral organs. In order to test the efficacy of the device and understand how the brain interprets vestibular signals during balance, this research aims to establish an animal model of balance control and examine the underlying neural mechanisms of the vestibular contribution to balance.

PI_NAMEs: LEAVITT, OLIVIA MARIE ELAINE (contact)

PROGRAM_OFFICER_NAME: SCHURMAN, JACLYN REBECCA

PROJECT_TERMS: Acclimatization;Address;Affect;American;Animal Model;Animals;Automobile Driving;Behavior;Behavioral;behavioral response;Bilateral;Biomimetics;body position;Brain;Brain Stem;Bypass;Cell Nucleus;Data;density;Development;Devices;efficacy testing;Emerging Technologies;Equilibrium;experience;experimental study;falls;Felis catus;free behavior;Freedom;Frequencies;functional improvement;Gait;Goals;Head;hexapod;Human;improved;Labyrinth;Macaca;Macaca mulatta;Maps;Measurement;Modeling;Monkeys;Motion;motor learning;Musculoskeletal Equilibrium;neural;neural implant;neuroadaptation;neuroepithelium;neuromechanism;Neurons;neuroregulation;novel;Numbness;Organ;Patients;Peripheral;Physiological;Postural response;Posture;Process;Prosthesis;Pulse Rates;Quality of life;Reaction;Reflex action;Research;response;restraint;Risk;Role;Series;Signal Transduction;Silicon;somatosensory;Stimulus;Surface;System;Testing;Vestibular dysfunction;Vestibular function;Vestibular loss;Vestibular Nerve;Vestibular nucleus structure;vestibular prosthesis;vestibular system;Vision;Visual;wireless;Work

PROJECT_TITLE: Neural Processing of Native and Prosthetic Vestibular Signals for Postural Control


ADMINISTERING_IC: AI

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology

ORG_CITY: STANFORD

ORG_DEPT: BIOLOGY

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: Project Narrative IgE antibodies interact with two receptors, the high affinity FceRI receptor and low affinity FceRII/CD23 receptor, to mediate different biological functions associated with the allergic cascade. In this proposal, we will investigate the structures and functions of anti-IgE and anti-FceRI antibodies and also probe how CD23 interacts with IgE and CD21 ligands. These studies will provide novel reagents for studying and blocking IgE:receptor interactions that centrally regulate the allergic response and new insights into the biological functions of IgE and its receptors.

PI_NAMEs: JARDETZKY, THEODORE S (contact)

PROGRAM_OFFICER_NAME: SUBRAMANIAN, HARIHARAN

PROJECT_TERMS: Acceleration;Address;Affinity;Allergens;Allergic;allergic response;Alpaca;Ankyrin Repeat;anti-IgE;Antibodies;antibody engineering;Antigens;arm;autoreactivity;B-Lymphocytes;Basophils;Binding;Biological;Biological Process;Cell Degranulation;Cell surface;Cells;Chronic;clinical application;Complement 3d Receptors;Complex;Coupled;Critical Thinking;Cryoelectron Microscopy;desensitization;design;design and construction;Directed Molecular Evolution;Disease;Dissociation;Dose;Effector Cell;Engineering;Epithelial Cells;Epitope Mapping;Epitopes;Equilibrium;Excision;Fc Receptor;Hybrids;IgE;IgE Receptors;Immune;Immune response;Immunity;Immunization;Immunoglobulin G;inhibitor;insight;Kinetics;Lead;Libraries;Ligands;Link;Llama;Low affinity IgE receptor;Lysosomes;mast cell;Mediating;Mediator;Molecular Conformation;Monoclonal Antibodies;nanobodies;neoplasm immunotherapy;novel;novel strategies;Patients;Play;Positioning Attribute;Production;Proteins;Protocols documentation;Reagent;receptor;receptor binding;Receptor Signaling;reconstruction;Regulation;Research;Resolution;Role;Route;Signal Pathway;Structure;Surface;Therapeutic;tool;Urticaria;Variant;Visualization;Yeasts

PROJECT_TITLE: Accelerated dissociation of IgE receptor complexes

STUDY_SECTION: MSFC

STUDY_SECTION_NAME: Macromolecular Structure and Function C Study Section[MSFC]


NIH_SPENDING_CATS: Cancer

PI_NAMEs: MARKIEWICZ, MARY A (contact)

PROJECT_TERMS: Adopted;Award;Binding;Biomedical Research;Budgets;Cancer Center;Cancer Center Support Grant;Cell Separation;Cells;Centers of Research Excellence;chemokine;Clinical Trials;Communities;Complex;Contracts;Core Facility;Correlative Study;cytokine;data acquisition;Data Analyses;Data Storage and Retrieval;Doctor of Philosophy;Education;Experimental Designs;Fees;Flow Cytometry;Flow Cytometry Shared Resource;Fostering;Foundations;Funding;Grant;Hematopoietic;Human;Immunologist;improved;Individual;Infrastructure;Institution;instrumentation;Journals;Kansas;Leadership;Measures;Medical center;member;Methods;Mission;National Institute of General Medical Sciences;new technology;novel;Paper;Preparation;Privatization;Procedures;programs;protocol development;Publications;quality assurance;rapid technique;Reporting;Research;Research Assistant;Research Personnel;Resource Sharing;Resources;Sampling;Schedule;Services;single-cell RNA sequencing;small molecule;Techniques;Technology;tool;Training;transcriptome sequencing;Translational Research;United States National Institutes of Health;Universities

PROJECT_TITLE: Flow Cytometry Shared Resource


NIH_SPENDING_CATS: Biotechnology;Cancer

PI_NAMEs: WEIR, SCOTT JAMES (contact)

PROJECT_TERMS: Acceleration;Adoption;Area;bench-to-bedside translation;Biochemical;Biological Assay;Biological Products;Biology;Biophysics;Cancer Center;catalyst;Chemistry;Clinical;Clinical Pharmacology;Clinical Trials;Consultations;cost;Data;design;Development;Discipline;Dosage Forms;Drops;drug candidate;Drug Delivery Systems;drug development;drug discovery;Drug Kinetics;Drug or chemical Tissue Distribution;Drug Targeting;early phase clinical trial;Ensure;Equipment;Evaluation;experience;first-in-human;Formulation;Funding;Generations;Goals;Grant;high throughput screening;Human;In Vitro;in vivo;Industry;innovation;International;invention;Investigational Therapies;investigator-initiated trial;Kansas;Laboratories;Language;Lead;Libraries;Malignant Neoplasms;Medical;member;method development;Methods;Mission;notch protein;novel;patient population;Peer Review;Pharmaceutical Chemistry;Pharmaceutical Preparations;Pharmacology;Pharmacology Shared Resource;Pharmacy Schools;Phase;Phenotype;pre-clinical;Process;programs;Property;Publications;Qualifying;recruit;Research;Research Infrastructure;Research Personnel;research study;Research Support;Resource Sharing;Resources;Scientist;service delivery;Services;skills;Solubility;Structure;Synthesis Chemistry;Testing;Therapeutic Agents;Therapeutic Trials;timeline;Training;Translational Research;Universities;University resources;Validation

PROJECT_TITLE: Lead Development & Optimization Shared Resource


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Microbiome;Nutrition;Obesity;Prevention

PI_NAMEs: HAMILTON-REEVES, JILL REEVES (contact)

PROJECT_TERMS: Address;Area;Behavior Therapy;Biolectric Impedance;Biological Markers;Body Composition;Budgets;Cancer and Nutrition;Cancer Burden;Cancer Center;cancer prevention;cancer risk;Cancer Survivor;Cancer Survivorship;cancer therapy;Carotenoids;Catchment Area;Clinic;Clinical;Clinical Research;Clinical Sciences;Collaborations;Collection;Communities;community collaboration;Community Outreach;Computer software;Consultations;continuing medical education;cooking;Counseling;Data;Data Analyses;design;Development;Diet;Dietary intake;Dietary Intervention;Dietitian;Doctor of Philosophy;Dual-Energy X-Ray Absorptiometry;Educational Curriculum;Educational Materials;energy balance;Faculty;Fostering;Funding;Generations;Goals;Grant;gut microbiome;Health Personnel;Health Professional;Hospitals;implementation design;implementation intervention;Information Systems;innovation;instrument;instrumentation;Intermittent fasting;Kansas;ketogenic diet;Licensing;life span;literacy;Location;Malignant Neoplasms;Malnutrition;Measurement;Medical Nutrition Therapy;member;Metabolic;meter;Methods;microbiome;microbiome composition;NCI-Designated Cancer Center;next generation;nutrition;Nutrition Assessment;nutrition education;Obesity;Oncology;Outcome;outreach;peer support;Persons;Phase;Physical activity;Pisum sativum;population health;preclinical study;prevent;Process;Professional counselor;programs;protocol development;Reporting;Research;Research Design;Research Personnel;Resource Sharing;Resources;Risk Factors;Rural Population;Science;Scientist;screening;Services;Site;Skin;Special Population;Standardization;Support Groups;survivorship;systems research;Therapeutic;Therapeutic Trials;therapy design;Training;Training and Education;Translational Research;Underserved Population;Universities;Vision;Weight maintenance regimen;Work;Youth

PROJECT_TITLE: Nutrition Shared Resource


NIH_SPENDING_CATS: Brain Disorders;Breast Cancer;Cancer;Cerebrovascular;Neurosciences;Women's Health Research

ORG_CITY: Columbus

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE Women diagnosed with breast cancer-associated brain metastases (BCBM) have an unacceptable median overall survival rate of 10-11 months. A major knowledge gap in understanding brain metastasis biology is the functional interplay between tumor cells and the metastatic brain tumor microenvironment (TME). The current application will advance this field by directly examining novel mechanisms of how the PDGFB–to-PDGFRβ signaling node, which is potentially druggable, promotes BCBM by creating a pro-tumorigenic immune microenvironment and by invoking vascular changes in collaboration with Angiopoietin-1.

PI_NAMEs: SIZEMORE, GINA MARIE (contact)

PROGRAM_OFFICER_NAME: GRIL, BRUNILDE M

PROJECT_TERMS: Ablation;Angiogenic Factor;Angiopoietins;ANGPT1 gene;Astrocytes;autocrine;Biology;Blood - brain barrier anatomy;Blood Vessels;blood-brain barrier permeabilization;Brain;Brain Neoplasms;brain remodeling;Breast Cancer Cell;breast cancer metastasis;Breast Cancer Patient;Breast Epithelial Cells;cancer diagnosis;Cells;cerebral microvasculature;clinically relevant;Coculture Techniques;Collaborations;Complex;Cytometry;Data;Diagnosis;Distant;Evaluation;experimental study;Fibroblasts;Human;Hyperactivity;Immune Evasion;immunoregulation;In Vitro;in vivo;inhibitor;Injections;Intracranial Neoplasms;Investigation;Knowledge;Ligands;Malignant - descriptor;Malignant Breast Neoplasm;Mammary Neoplasms;Mediating;Mesenchymal;Metastatic malignant neoplasm to brain;Microfluidics;Microglia;Molecular;mortality;mouse model;Mus;Myelogenous;Myeloid Cells;Neoplasm Metastasis;neoplastic cell;novel;Organ;Patients;PDGFRB gene;Pericytes;Phagocytes;Phenotype;Platelet-Derived Growth Factor;platelet-derived growth factor BB;Platelet-Derived Growth Factor beta Receptor;Platelet-Derived Growth Factor Receptor;Population;prognostic;Publishing;receptor;response;Signal Transduction;Site;small molecule;small molecule inhibitor;spheroids;Survival Rate;targeted treatment;Testing;therapeutic evaluation;Treatment Efficacy;tumor;tumor growth;tumor microenvironment;Tumor Promotion;tumor-immune system interactions;tumorigenic;Woman;women's diagnosis;Work

PROJECT_TITLE: PDGF-BB and the metastatic brain microenvironment

STUDY_SECTION: THI

STUDY_SECTION_NAME: Tumor Host Interactions Study Section[THI]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Genetics;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

PI_NAMEs: VIVIAN, JAY L (contact)

PROJECT_TERMS: Acceleration;Animal Husbandry;Animal Model;animal model development;Animals;anti-cancer research;Basic Science;Biopsy;blastocyst;Cancer cell line;Cancer Center;Cancer Model;Cell Culture Techniques;Cell Line;Cell model;cell type;Cells;Child;Cities;Clinical;Clinical Research;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;Consumption;cost;Cryopreservation;Cultured Cells;design;Development;Diagnostic;Doctor of Philosophy;Education;Educational workshop;Electroporation;Embryo;embryo cryopreservation;Engineering;Equipment;Etiology;Experimental Designs;experimental study;Fertilization in Vitro;follow-up;functional genomics;Funding;Gene Modified;Gene Targeting;Generations;Genetic Engineering;genetic manipulation;Genetic screening method;Genetically Engineered Mouse;Genetically Modified Animals;genome editing;genomic data;Genotype;Germ Lines;Human;in silico;in vivo Model;induced pluripotent stem cell;instrumentation;Investments;Kansas;lectures;Malignant Neoplasms;Medical center;member;Methodology;Methods;Microinjections;Micromanipulation;Modeling;Molecular;Molecular Biology;Monitor;Mouse Embryonic Stem Cells;mouse genetics;mouse model;Mouse Strains;Mus;Mutagenesis;Mutation;Nature;new technology;novel;Nucleic Acids;operation;pathogen;Patients;Phase;Pluripotent Stem Cells;Procedures;Process;Production;Reagent;reconstitution;Research;Research Personnel;Resource Sharing;Resources;response;Rodent;Services;Somatic Mutation;sperm cryopreservation;stem cell biology;stem cell model;Students;System;Technical Expertise;Techniques;Technology;Therapeutic;Time;Tissues;tool;transgene expression;Transgenic Organisms;transmission process;tumor;Tumor Cell Line;tumorigenesis;Universities;Validation;Variant;virtual;Work;zygote

PROJECT_TITLE: Transgenic & Gene-Targeting Shared Resource


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Pediatric;Physical Injury - Accidents and Adverse Effects;Prevention;Screening and Brief Intervention for Substance Misuse;Social Determinants of Health;Substance Misuse;Underage Drinking

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Binge drinking can lead to serious health and psychological consequences, especially in a military population where alcohol-related incidents can lead to a court martial and dishonorable discharge from service. Our proposed innovative distance-based option for lowering binge drinking incidents, if efficacious, could open new doors for health in the American military through a cost-effective, easy-to-implement intervention, and benefit both the individual and the military service he or she is part of, as well as providing a roadmap for programs for civilian adults.

PI_NAMEs: MCDEVITT-MURPHY, MEGHAN E.;TALCOTT, GERALD WAYNE;WISEMAN, KARA P (contact)

PROGRAM_OFFICER_NAME: RUFFIN, BEVERLY

PROJECT_TERMS: Accident and Emergency department;Adult;Air;alcohol abstinence;Alcohol abuse;alcohol availability;Alcohol consumption;alcohol involvement;alcohol misuse;alcohol research;Alcohols;American;automated text message;Automobile Driving;base;binge drinking;brief alcohol intervention;Cause of Death;Certificate of Confidentiality;Cessation of life;college;Consumption;cost;cost effective;Counseling;court;data anonymization;Deaths of despair;drinking;drinking behavior;driving under influence;Effectiveness;efficacious intervention;efficacy evaluation;Epidemic;Event;experience;Feedback;follow-up;Gender;group intervention;Harm Reduction;hazardous drinking;Health;Health behavior;Health Promotion;Heavy Drinking;High Prevalence;high risk;improved;Individual;Injury;innovation;Intervention;intervention effect;Intervention Studies;Legal;Literature;live text;Methods;Military Personnel;military service;Monitor;motivational enhancement therapy;opioid overdose;Outcome;overdose death;Patient Self-Report;Population;post intervention;prevent;Privileged Communications;Professional counselor;programs;psychologic;Public Health;Publishing;Punishment;Randomized;recruit;Reporting;Research;Risk;Risk Reduction;Safety;Sampling;Services;sexual assault;smoking cessation;social;substance use;Suicide;Surveys;Techniques;Testing;Text;Text Messaging;text messaging intervention;Time;Training;treatment effect;Treatment Efficacy;underage drinking;United States;universal prevention;Work;young adult

PROJECT_TITLE: The effectiveness of text-based messaging strategies for preventing subsequent problematic alcohol use among technical trainees in the U.S. Air force

STUDY_SECTION: ARM

STUDY_SECTION_NAME: Addiction Risks and Mechanisms Study Section[ARM]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: NEW YORK

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: NEW YORK UNIVERSITY

ORG_STATE: NY

PHR: In general, GPCRs activate G protein signaling at the cell surface, which is followed by rapid signal desensitization and receptor internalization by -arrestins. However, recent studies suggest that some receptors continue to stimulate G proteins after they have been internalized into endosomes by -arrestins in an unappreciated conformation. As endosomal G protein signaling is associated with unique physiological functions, this project seeks to understand the underlying receptor/-arrestin properties that drive this mechanism, which can be leveraged for future drug development efforts.

PI_NAMEs: THOMSEN, ALEX ROJAS BIE (contact)

PROGRAM_OFFICER_NAME: LEWIS, MECHELLE MAYLEBEN

PROJECT_TERMS: Agonist;Arrestins;beta-arrestin;Binding;Binding Sites;Biochemical;Biological;C-terminal;Cell surface;Cells;Complex;Coupling;Cyclic AMP;Data;desensitization;design;driving force;drug development;Drug Prescriptions;Drug Targeting;Endocytosis;Endosomes;Future;G protein coupled receptor kinase;G Protein-Coupled Receptor Signaling;G-Protein-Coupled Receptors;GTP-Binding Protein Regulators;GTP-Binding Proteins;Heterotrimeric GTP-Binding Proteins;Hydrophobicity;innovation;Knowledge acquisition;Location;Mediating;Membrane;Molecular;Molecular Conformation;phosphoric diester hydrolase;Phosphorylation;Phosphorylation Site;Physiological;Physiological Processes;programs;Property;Proteomics;receptor;receptor internalization;recruit;Regulation;Research;response;Signal Transduction;Signaling Protein;spatiotemporal;Tail;Therapeutic;Time;Vision

PROJECT_TITLE: Spatiotemporal Regulation of GPCR Signaling by Different Beta-Arrestin Conformations

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-M(55)R]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Bioengineering;Biotechnology

ORG_CITY: LINCOLN

ORG_NAME: UNIVERSITY OF NEBRASKA LINCOLN

ORG_STATE: NE

PHR: PROJECT NARRATIVE The development of drugs targeting RNA, RNA therapeutics, and our fundamental understanding of biological processes is hindered by incomplete RNA structure and function models. This research program will generate predictive models of RNA conformational dynamics, RNA-ligand binding, and RNA catalysis. This work will transform our understanding of RNA machines, assist in developing new RNA-targeted drugs, and contribute to generating life-saving RNA therapeutics.

PI_NAMEs: YESSELMAN, JOSEPH  (contact)

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TERMS: 3-Dimensional;Address;Affect;Area;Binding;Biochemical;Biochemical Reaction;Biological Assay;Biological Process;biophysical model;Biosensor;Catalysis;Catalytic RNA;conformational conversion;Cryoelectron Microscopy;design;Development;Devices;Diagnostic;Disease;drug development;Drug Interactions;experimental study;Goals;improved;Knowledge;Life;Ligand Binding;Ligands;Machine Learning;Methods;Modeling;Molecular Conformation;molecular recognition;next generation;novel;Pharmaceutical Preparations;Phylogenetic Analysis;Play;predictive modeling;programs;Proteins;Research;Resolution;RNA;RNA Conformation;RNA Folding;RNA Probes;RNA-targeting therapy;Role;scaffold;small molecule;Structure;Therapeutic;therapeutic RNA;Thermodynamics;three dimensional structure;Work

PROJECT_TITLE: Next-generation biophysical models for RNA dynamics, ligand binding, and catalysis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BCMB-B(55)]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Chronic Pain;Clinical Research;Neurosciences;Pain Research;Pediatric

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

PHR: PROJECT NARRATIVE The proposed research will provide critical new information about the presence and impact of disrupted spatial and temporal nociceptive processing in youth with localized chronic pain and chronic overlapping pain conditions (COPCs). The study will also provide insight into which individuals are more likely to transition from a single pain condition to COPCs, providing an opportunity for early identification by screening for disrupted nociceptive processing and prioritization of these at-risk patients for intensive care, multidisciplinary therapy. Leveraging the current study, our long-term objectives are to reduce the development of COPCs, which closely aligns with the NIH’s Federal Pain Research Strategy and National Institute of Neurological Disorders and Stroke (NINDS) to reduce the public health burden of chronic pain across the lifespan.

PI_NAMEs: KING, CHRISTOPHER D (contact)

PROGRAM_OFFICER_NAME: OSHINSKY, MICHAEL L

PROJECT_TERMS: Abdominal Pain;Absence of pain sensation;Adolescent;Adult;Age;Awareness;Back;Behavioral;biopsychosocial;Central Nervous System;Childhood;Chronic;Chronic disability;chronic pain;chronic painful condition;Clinic;clinical infrastructure;clinically relevant;conditioned pain modulation;Control Groups;daily functioning;design;Development;Dimensions;disability;Early identification;Enrollment;experience;Female;Foundations;Future;Gastroenterology;Goals;high risk;Individual;Individual Differences;innovation;insight;Intensive Care;Knowledge;life span;longitudinal design;Medical center;Methods;Migraine;multidisciplinary;Musculoskeletal;Musculoskeletal Pain;National Institute of Neurological Disorders and Stroke;Neurosciences;Nociception;Pain;Pain management;Pain Research;Participant;patient subsets;Patients;Pattern;Pharmaceutical Preparations;Phenotype;Pilot Projects;Positioning Attribute;prevent;Prevention;programs;prospective;psychosocial;Public Health;Quality of life;recruit;Research;Rheumatology;Risk;Risk Factors;Sampling Studies;screening;Sensory;sex;Sleep;somatosensory;stability testing;Stimulus;Stress;Testing;Time;traumatic event;United States National Institutes of Health;Youth

PROJECT_TITLE: Disrupted Spatial and Temporal Nociceptive Filtering in Adolescents with and Risk for Overlapping Pain Conditions

STUDY_SECTION: NPI

STUDY_SECTION_NAME: Neurobiology of Pain and Itch Study Section [NPI]


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Clinical Research;Dissemination and Implementation Research;Emergency Care;Health Services;Networking and Information Technology R&D (NITRD);Physical Injury - Accidents and Adverse Effects;Telehealth

ORG_CITY: SALT LAKE CITY

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE/ RELEVANCE TO PUBLIC HEALTH Nearly half of the preventable deaths worldwide can be addressed through rapid delivery of effective emergent care. We propose to establish “Rwanda912” as an innovative mHealth platform to improve the existing prehospital system by accurately locating patients and facilitating communication between dispatch, ambulance and emergency triage staff in Kigali, Rwanda. We hypothesize that this novel platform will be feasible and acceptable to these three stakeholder groups and will improve the delivery of timely and effective prehospital care.

PI_NAMEs: JAYARAMAN, SUDHA  (contact)

PROGRAM_OFFICER_NAME: NEWSOME, BRAD

PROJECT_TERMS: Acceleration;acceptability and feasibility;Accident and Emergency department;Accounting;Address;Ambulances;Caring;Cessation of life;Clinical;clinical outcome assessment;Collaborations;Communication;Computer software;Country;Data;Data Collection;design;doctoral student;effectiveness evaluation;effectiveness/implementation design;electronic data;Emergency Care;Emergency Situation;Emergent care;Ensure;Equipment;Fostering;Foundations;Funding;Future;Health;Hospitals;implementation evaluation;improved;Income;injured;innovation;Interruption;Intervention;Lead;Location;low and middle-income countries;Medical emergency;Methods;mHealth;Mobile Health Application;Modeling;mortality;Myocardial Ischemia;novel;Outcome;Outcome Measure;Patients;Phase;Positioning Attribute;post implementation;Pre-hospitalization care;Prehospital Emergency Care;prevent;preventable death;primary outcome;Process;Process Measure;Proctor framework;Public Health;Readiness;Registries;research and development;Respiratory Tract Infections;Running;Rwanda;secondary outcome;Series;Services;simulation;Stroke;Students;Subgroup;System;Teaching Hospitals;Testing;Time;tool;Training;Trauma;trauma care;trauma centers;Trauma patient;Triage;Universities;Voice;World Bank;years of life lost

PROJECT_TITLE: Rwanda 912: an mHealth Application to Improve Quality of Trauma and Emergency Care in Kigali, Rwanda


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: DAYTON

ORG_DEPT: PHYSIOLOGY

ORG_NAME: WRIGHT STATE UNIVERSITY

PHR: Project Narrative Hyperkalemic periodic paralysis causes debilitating attacks of paralysis and weakness in patients, and these attacks last from minutes to days. The only FDA-approved treatment provides only modest relief and can include painful side effects and cognitive disorders. The proposed work is relevant to public health because it uses a novel correlated study design to examine a novel disease alteration and a novel therapeutic, both supported by pilot data.

PI_NAMEs: DUPONT, CHRISTOPHER  (contact)

PROGRAM_OFFICER_NAME: LINDHURST, MARJORIE JEAN

PROJECT_TERMS: Action Potentials;Address;Calcium;channel blockers;Clinical;Clinical Research;Clinical Trials;Cognition Disorders;Collaborations;Complex;Conotoxin;Correlation Studies;Coupling;Data;Disease;disease model;effective therapy;Electrophysiology (science);Event;experience;experimental study;Failure;Family;FDA approved;Fiber;Future;gain of function mutation;Generations;Genes;Goals;Hyperkalemic periodic paralysis;Infusion procedures;Inherited;Ions;Knowledge;Measurement;Measures;Membrane Potentials;Modeling;Molecular Conformation;mouse model;Mus;Muscle;Muscle Fibers;Muscular Atrophy;mutant;Mutation;Myopathy;novel;novel strategies;novel therapeutics;Pain;Paralysed;Pathologic;Patients;Pharmaceutical Preparations;prevent;Public Health;Research Design;Role;Series;side effect;Skeletal Muscle;Sodium Channel;Specificity;Techniques;Testing;therapy development;Translating;voltage clamp;Wild Type Mouse;Work

PROJECT_TITLE: Treating Hyperkalemic Periodic Paralysis


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Rare Diseases;Tickborne Diseases;Vector-Borne Diseases

ORG_CITY: GAINESVILLE

ORG_DEPT: ZOOLOGY

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE The prevalence of tick-borne rickettsial diseases (TBRDs) has steadily increased worldwide and it has become vital to develop a deeper understanding of the mechanisms that contribute to rickettsial pathogenicity and horizontal transmission of Rickettsia. The studies outlined in this proposal aim to fill significant knowledge gaps pertaining to the rickettsial-induced determinants of horizontal transmission and the basic biology of salivary gland function and tick bloodmeal feeding. These studies are needed to resolve the epidemiology of SFG rickettsioses and identify novel points of intervention to reduce the burden of TBRDs.

PI_NAMEs: SWALE, DANIEL  (contact)

PROGRAM_OFFICER_NAME: PERDUE, SAMUEL S

PROJECT_TERMS: Acinus organ component;Address;Amblyomma;Arthropod Vectors;Arthropods;Automobile Driving;Biological Assay;Biology;Blood;Case Fatality Rates;Cells;Cessation of life;comparative;Data;Development;Disease Clusterings;disease model;disorder control;Ecology;effective therapy;endosymbiont;Epidemiology;Epithelium;experimental study;feeding;Gland;Health;Homeostasis;Horizontal Disease Transmission;Human;human pathogen;Incidence;Infection;innovation;interdisciplinary approach;Interruption;Intervention;Invaded;Ions;Kinetics;Knowledge;Life Cycle Stages;Maintenance;Measures;Mediating;Membrane;Membrane Potentials;Methods;Modification;Molecular Genetics;novel;novel strategies;Organism;pathogen;pathogenic bacteria;Pathogenicity;Pathway interactions;pharmacologic;Physiological;Physiology;Population;Potassium;potassium ion;Prevalence;prevent;Protein Secretion;Proteins;Publishing;Regulation;Research;response;Rickettsia;Rickettsia Infections;Rickettsia parkeri;Saliva;saliva secretion;Salivary Glands;spotted fever;Testing;therapeutic development;Tick Control;tick feeding;tick saliva;tick transmission;tick-borne;Tick-Borne Diseases;tick-borne pathogen;Ticks;tool;transmission process;United States;vector;vector tick;Vertical Transmission;Virulence

PROJECT_TITLE: Rickettsial Influence on Host Membrane Physiology in Arthropod Vectors

STUDY_SECTION: VB

STUDY_SECTION_NAME: Vector Biology Study Section[VB]


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Antimicrobial Resistance;Biotechnology;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: PISCATAWAY

ORG_DEPT: MISCELLANEOUS

ORG_NAME: RUTGERS, THE STATE UNIV OF N.J.

ORG_STATE: NJ

PHR: PROJECT NARRATIVE While bacterial stress responses are essential for adaptation to harsh environments and cell survival, they also contribute to the rise of antimicrobial resistance – an alarming problem of the present and future. To gain a fundamental understanding of the underlying biochemical pathways, our studies will focus on two distinct, emerging classes of regulators – small proteins and epitranscriptomic factors, and their contribution to bacterial stress responses. Our research will provide key insights into bacterial regulatory networks, which will be useful for developing effective therapeutic interventions against multi-drug resistant bacteria.

PI_NAMEs: YADAVALLI, SRUJANA SAMHITA (contact)

PROGRAM_OFFICER_NAME: RIGAS, MARC

PROJECT_TERMS: Affect;Amino Acids;Anabolism;anti-microbial peptide;Antibiotics;Antimicrobial Resistance;attenuation;Bacteria;Bacterial Genes;Biochemical Pathway;biochemical tools;biological adaptation to stress;Biology;Cell division;Cell Physiology;Cell Survival;crosslink;design;Environment;Enzymes;epitranscriptomics;Escherichia coli;Eukaryota;experience;Future;Gene Expression;Gene Expression Regulation;gene repression;Genes;Genetic;Genetic Transcription;genome annotation;Growth and Development function;in vivo;insight;link protein;Mass Spectrum Analysis;Measures;Metabolism;Methods;Modification;Multiple Bacterial Drug Resistance;novel;Nucleoside Q;Open Reading Frames;Phosphotransferases;Physiology;Play;programs;Prokaryotic Cells;Proteins;Proteomics;Regulation;Regulatory Pathway;Research;response;ribosome profiling;RNA;Role;sensor;Signal Transduction;Site;Stress;stressor;System;Textbooks;Therapeutic;Therapeutic Intervention;therapeutically effective;transcription factor;Transfer RNA;Translations;Work

PROJECT_TITLE: Small Proteins and Epitranscriptomic Factors: Emerging Mechanisms in Bacterial Gene Regulation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-GGG-X(55)R]


ADMINISTERING_IC: DK

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: PROJECT NARRATIVE The primary goal of the Research Training in Neuroendocrinology and Metabolism Program at the University of Virginia is to prepare early-postdoctoral fellows for future research careers in the various fields of metabolism and neuroendocrinology. This investment promises availability of the next generation of scientists and investigators that would help fashion newer treatment strategies for a host of important health problems such as obesity, diabetes, hypertension, cardiovascular illnesses, neurological ailments, renal disorders and infertility.

PI_NAMEs: LIU, ZHENQI  (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Autoimmune Disease;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Multiple Sclerosis;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: NEW ORLEANS

ORG_DEPT: NEUROLOGY

ORG_NAME: LSU HEALTH SCIENCES CENTER

ORG_STATE: LA

PHR: Project Narrative  Multiple sclerosis is a debilitating neurological condition which the NINDS has identified as a high priority target area and the proposed research aligns with the mission as it examines how individual difference characteristics such as race and stress exposure can explain why brain atrophy does not sufficiently predict clinical MS outcomes. Doing so will aid in the diagnosis, prevention, and treatment of MS. In addition to proposing research which will help address racial health disparities, the proposal aligns with the NIH Blueprint and NINDS commitment to supporting a diverse and inclusive neuroscience workforce by supporting innovative translational clinical research training for a highly promising scholar.

PI_NAMEs: MOODY, SHANNIN NICOLE (contact)

PROGRAM_OFFICER_NAME: BENSON, RICHARD T

PROJECT_TERMS: Address;Age;Area;Behavioral;biobehavior;biological adaptation to stress;Biological Assay;Biological Markers;Biology;biopsychosocial;Black American;Black race;Brain;brain tissue;career;Career Mobility;Central Nervous System;cerebral atrophy;Characteristics;Clinical;clinical predictors;clinical translation;Cognition;Cognitive;cohort;Complement;Critical Race Theory;Data;Data Collection;Demyelinations;Development;Diagnosis;Discrimination;Disease;Disease Progression;Economics;Electroencephalography;environmental stressor;Ethnic Origin;Etiology;experience;Funding;Gender;Glucocorticoid Receptor;Goals;Guidelines;Hair;Head Start Program;Health;health disparity;Hydrocortisone;hypothalamic-pituitary-adrenal axis;Impairment;Incidence;indexing;Individual;Individual Differences;innovation;Internships;intersectionality;Iowa;Knowledge;learning community;Lesion;Life Experience;longitudinal dataset;Longitudinal Studies;Magnetic Resonance Imaging;matriculation;Measurable;Measurement;Measures;men;Mental Health;Mentors;Methodology;Mission;Modeling;mortality;MRI Scans;Multiple Sclerosis;multiple sclerosis patient;multiple sclerosis treatment;National Institute of Neurological Disorders and Stroke;Nerve Degeneration;Nervous System Disorder;neural;Neuroanatomy;Neurodegenerative Disorders;neuroimaging;Neurologic;Neurosciences;novel;Outcome;Outcome Measure;Participant;Patient Self-Report;Phase;phenomenological models;Physiological;post-doctoral training;Postdoctoral Fellow;power analysis;pre-doctoral;Prevalence;Prevention;Psychosocial Stress;psychosocial stressors;Race;racial discrimination;racial health disparity;racial population;racism;Recording of previous events;Research;Research Project Grants;Research Technics;Research Training;Risk;Science;Severities;Severity of illness;Site;skills;Skin;social influence;social stressor;Socioeconomic Status;Source;Stress;study population;success;System;Testing;theories;Third ventricle structure;Training;Trauma;United States National Institutes of Health;Width;Woman;Work;young adult

PROJECT_TITLE: Stress Biology and Psychosocial stressors as mechanisms for Racial Health Disparities in Neural and Clinical Impairments of Multiple Sclerosis


NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Brain Disorders;Mental Health;Networking and Information Technology R&D (NITRD);Neurosciences;Patient Safety

ORG_CITY: SAN FRANCISCO

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project narrative Novel implantable brain devices that can sense neural activity, as well as deliver therapeutic stimulation, have recently become available and may lead to new therapies for brain disorders. However, use of the most flexible and powerful of these neural interfaces requires expertise in software and in device regulatory requirements that is unfamiliar to most investigators. Our group, which has already launched clinical trials using the novel sensing interfaces, here forms a “neural communications consortium” to disseminate technical and regulatory knowledge to new users, which will be critical for launching investigational studies.

PI_NAMEs: BORTON, DAVID ALLENSON;DENISON, TIMOTHY ;STARR, PHILIP ANDREW (contact);WORRELL, GREGORY A

PROGRAM_OFFICER_NAME: TRZCINSKI, NATALIE KATHERINE

PROJECT_TERMS: Acceleration;Address;Algorithms;Animals;application programming interface;Architecture;Area;Behavior monitoring;Biological Markers;Brain;Brain Diseases;brain disorder therapy;BRAIN initiative;Chronic;Clinic;Clinical;Clinical Protocols;Clinical Research;Clinical Trials;Cognition Disorders;Communication;Communities;Computer software;Computers;Consultations;Coupled;Data Set;data tools;design;Development;Devices;Documentation;Ecosystem;Education;Educational Materials;Educational workshop;Elements;Ensure;Epilepsy;Evaluation;experience;Feedback;flexibility;Funding;Generations;Goals;Grant;Home;Human;IACUC;Implant;implantable device;improved;Informed Consent;Infrastructure;Institution;Institutional Review Boards;Instruction;Intellectual Property;interest;International;Knowledge;Laboratories;Libraries;meetings;Mental disorders;Methods;Mind;Movement Disorders;Nervous System;neural;neural implant;neuroregulation;Neurosciences;neurotechnology;new technology;novel;novel therapeutics;Online Systems;open source;pathway tools;Patients;Performance;Physiological;Preparation;Process;Protocols documentation;Psychiatry;rational design;Readiness;Regulation;Regulatory Pathway;Research;Research Personnel;Resolution;Resources;Risk Assessment;Risk Management;risk mitigation;Signal Transduction;Software Validation;Stream;Structure;symposium;System;system architecture;Techniques;Technology;Testing;Therapeutic;Time;tool;Translations;United States National Institutes of Health;Universities;Update;verification and validation;Visualization;wireless;wireless data transmission;wireless implant;Work;Writing

PROJECT_TITLE: Accelerating Dissemination of Implantable Neurotechnology for Clinical Research


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

ORG_CITY: WALTHAM

ORG_NAME: BRANDEIS UNIVERSITY

ORG_STATE: MA

PHR: Project Narrative Targeted protein degradation is an exciting new strategy in drug design. These small molecule degraders induce the modification of the target protein with ubiquitin. This proposal investigates new methods of targeted protein degradation that are ubiquitin independent, and thus should avoid the issues that limit current methods of targeted protein degradation.

PI_NAMEs: HEDSTROM, LIZBETH K. (contact)

PROGRAM_OFFICER_NAME: ASLAN, KADIR

PROJECT_TERMS: 26S proteasome;Active Sites;Address;antagonist;Binding;cancer therapy;Cells;Chimera organism;Complex;Cyclization;design;Diabetes Mellitus;Disease;DNA;Dose;Drug Design;drug discovery;Event;experimental study;Goals;Grant;improved;In Vitro;Inflammation;inhibitor;innovation;insight;Laboratories;Libraries;Ligand Binding;Ligands;Ligase;Link;Malignant Neoplasms;Messenger RNA;Methods;multicatalytic endopeptidase complex;Nature;particle;Peptide Hydrolases;Peptides;peptidomimetics;Permeability;Pharmaceutical Preparations;Positioning Attribute;Post-Translational Protein Processing;Proteasome Binding;protein degradation;Proteins;prototype;rational design;receptor;response;Role;Route;Site-Directed Mutagenesis;small molecule;tissue/cell culture;Tissues;UBA Domain;Ubiquitin;ubiquitin-protein ligase;Ubiquitination;UBQLN1 gene;unfoldase;unnatural amino acids;Work

PROJECT_TITLE: Ubiquitin-independent targeted protein degradation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BCMB-A(51)]


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Genetics;Immunotherapy;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Narrative CD4+ T memory stem cells are long-lived precursor cells that possess the ability to self-renew and differentiate into specific T cell subtypes. T memory stem cells are likely key in prolonged availability of autoreactive T effector cells in autoimmune diseases such as type 1 diabetes and rheumatoid arthritis. Insights into the regulation of these cells in a cell-type- and disease-specific manner can be gained through the investigation of cis-regulatory elements and changes in three-dimensional genome architecture that defines control of target gene expression.

PI_NAMEs: HAWKINS, RAYMOND DAVID (contact)

PROGRAM_OFFICER_NAME: BLONDEL, OLIVIER

PROJECT_TERMS: 3-Dimensional;Architecture;ATAC-seq;Autoimmune;Autoimmune Diseases;autoimmune pathogenesis;Autoimmunity;autoreactivity;CD4 Positive T Lymphocytes;cell type;Cells;Chromatin;Chronic Disease;cohort;Collaborations;Complex;Data;Disease;disorder risk;effector T cell;Environmental Risk Factor;Gene Expression;Gene Expression Regulation;Genes;Genetic;Genome;Goals;Human;immune function;immune reconstitution;Immune system;Immunologic Memory;Immunologics;Immunotherapy;improved;Inflammation;Inflammatory;innovation;insight;Insulin-Dependent Diabetes Mellitus;Investigation;long term memory;Maps;member;Memory;Molecular Conformation;Pathogenesis;Phenotype;Play;Population;precursor cell;Process;progenitor;Property;Regulation;Regulatory Element;Regulatory T-Lymphocyte;Rheumatoid Arthritis;risk variant;Role;self-renewal;Source;Specificity;stem;stem cells;stemness;superresolution microscopy;T memory cell;T-Lymphocyte;transcriptome sequencing;Tumor Immunity;two-dimensional;Untranslated RNA;Variant;Work

PROJECT_TITLE: Three-dimensional conformation changes associated with T cell memory and autoimmunity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-S(70)R]


NIH_SPENDING_CATS: Digestive Diseases;Pediatric

ORG_CITY: Aurora

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Narrative This Pediatric GI T32 Training Program is directly relevant to child health by training the next generation of physician scientists who will be essential to advance the care and improve the quality of life of children and adolescents with GI, hepatology and nutritional disorders. The investment in multidisciplinary bench to bedside research training in this Training Program will provide a foundation for the trainees to become the future leaders, researchers and mentors who will help guide the direction of GI, hepatology and nutrition in the future.

PI_NAMEs: DE ZOETEN, EDWIN FULCO;SOKOL, RONALD J. (contact)

PROGRAM_OFFICER_NAME: SERRANO, KATRINA JANE

PROJECT_TITLE: Institutional Training Grant in Pediatric Gastroenterology


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Hematology;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pediatric;Sepsis;Telehealth

ORG_CITY: PROVIDENCE

ORG_NAME: RHODE ISLAND HOSPITAL

ORG_STATE: RI

PHR: Project Narrative Worldwide, sepsis is responsible for the majority of deaths in children each year with most of these deaths occurring in low and middle-income countries (LMICs), yet few clinical tools have been developed for identifying, monitoring, or managing children with sepsis in LMICs. The proposed research will develop and validate a mobile health tool which links continuous physiologic data obtained remotely from a wearable device with a standard smartphone and machine learning approach known as personalized physiologic analytics to provide clinicians with accurate assessments of advanced stages of sepsis (severe sepsis, septic shock, multiple organ dysfunction syndrome), and risk of death in septic children without the need for laboratory diagnostics or expensive monitoring equipment. By enabling detection of subtle physiologic changes indicating clinical deterioration, these tools may allow clinicians to intervene earlier, better direct care, and allocate scarce resources, thereby reducing child morbidity and mortality from sepsis.

PI_NAMEs: GARBERN, STEPHANIE CHOW (contact);LEVINE, ADAM CARL

PROJECT_TERMS: 2019-nCoV;acute infection;Admission activity;Algorithms;analytical tool;Artificial Intelligence;Bangladesh;base;Caring;Cellular Phone;Cessation of life;Child;Child Mortality;Childhood;Clinical;clinical care;clinical decision support;Clinical Trials;co-infection;Communicable Diseases;cost effectiveness;COVID-19;Critical Care;Critical Illness;Critically ill children;Data;Detection;Deterioration;Development;Devices;Diagnostic;Diarrhea;diarrheal disease;Disease;Disease Outbreaks;Early Diagnosis;Enrollment;Equipment;evidence base;Functional disorder;Future;Health Personnel;Health protection;health training;high risk;Hospitals;Immune response;implementation framework;improved;individual patient;Industry;Infection;Infrastructure;Interdisciplinary Study;International;international center;Knowledge;Laboratories;Life;Link;low and middle-income countries;Machine Learning;Malaria;Malnutrition;Medical;mHealth;Modeling;Monitor;Morbidity - disease rate;mortality;mortality risk;Multi-Institutional Clinical Trial;Multiple Organ Failure;novel;novel coronavirus;Organ;Outcome;Patient Admission;Patient Care;Patient Monitoring;patient population;patient response;Patients;pediatric patients;pediatric sepsis;Phase;Physiologic Monitoring;Physiological;Pneumonia;Population;prevent;Proliferating;prospective;remote monitoring;Research;Research Personnel;Resources;Running;Safety;Scientist;Sepsis;septic;Septic Shock;Severities;skills;Stratification;System;Techniques;Technology;Therapeutic Intervention;Time;tool;treatment response;usability;user centered design;user-friendly;Variant;wearable device;wearable sensor technology

PROJECT_TITLE: Development of a Mobile Health Personalized Physiologic Analytics Tool for Pediatric Patients with Sepsis


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

ORG_CITY: BATON ROUGE

ORG_NAME: LSU PENNINGTON BIOMEDICAL RESEARCH CTR

PHR: Chronic and diabetic kidney disease are the most significant complications of diabetes. The current project aims to decipher the role of specific lipid peroxides – a selective form of oxidative stress - in kidney injury. We seek to identify the molecular identity, renal cell-specific sources, and production mechanisms of oxidized lipids, in order to be able to design better approaches to prevent, arrest or postpone kidney disease.

PI_NAMEs: STADLER, KRISZTIAN  (contact)

PROGRAM_OFFICER_NAME: NIHALANI, DEEPAK

PROJECT_TERMS: Ablation;Acyl Coenzyme A;Address;Antioxidants;Apoptosis;Apoptotic;Arachidonate 15-Lipoxygenase;Attributes of Chemicals;Biochemical;Biological;Biology;biophysical techniques;Biophysics;Cell Death;Cell Death Signaling Process;cell injury;Cell Physiology;Cells;Cellular Metabolic Process;Chronic;Chronic Kidney Failure;Coenzyme A Ligases;cold temperature;Complex;Complications of Diabetes Mellitus;Consumption;Coupled;Cytoplasm;Data;Dependence;design;Diabetes Mellitus;diabetic;Diabetic Nephropathy;diet-induced obesity;Disease;Distant;Electron Spin Resonance Spectroscopy;Epithelial Cells;Equilibrium;Event;experimental study;feeding;Foundations;Free Radicals;Functional disorder;Future;Generations;glutathione peroxidase;imaging modality;in vivo;Injury;Injury to Kidney;Intervention;Iron;Iron Chelation;Kidney;kidney cell;Kidney Diseases;Kinetics;Link;Lipid Peroxidation;Lipid Peroxides;Lipids;Lysophospholipids;mass spectrometric imaging;Mediator;Membrane;Metabolic;Metabolism;Mitochondria;mitochondrial dysfunction;Modeling;Molecular;Molecular Profiling;Monitor;mouse model;Mus;novel;Obesity;Outcome;oxidation;Oxidation-Reduction;Oxidative Stress;oxidized lipid;Oxygen;Pathogenesis;Pathway interactions;peroxidation;Peroxides;pharmacologic;Phosphatidylethanolamine;Phospholipids;prevent;Production;programs;Proteins;Publishing;Reaction;Reactive Oxygen Species;Role;Signal Transduction;Site;Source;Specificity;Stress;Structure;successful intervention;Superoxides;Testing;Transgenic Model;Transgenic Organisms;transmission process;Tubular formation;Work

PROJECT_TITLE: Novel redox mechanisms of oxygenated phospholipids in chronic and diabetic kidney disease

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Genetics;Human Genome;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Radiation Oncology;Rare Diseases

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE - This research will be the first to provide a proof-of-principle demonstration that targeting transcriptional initiation and elongation is an effective therapeutic strategy in diffuse intrinsic pontine glioma (DIPG), one of the most devastating childhood cancers. This project will also explore how a novel combination therapy interacts with radiation, which is important due to the frequent use of radiation in treating DIPG patients. The successful completion of proposal study will ultimately lead to improved treatment outcomes for patients afflicted with a currently incurable pediatric brain tumor, that is therefore relevant to public health and the mission of the National Institute of Neurological Disorders and Stroke (NINDS), which is to seek fundamental knowledge about the brain and the nervous system and to use that knowledge to advance cures for neurological diseases.

PI_NAMEs: HASHIZUME, RINTARO  (contact)

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: Acetylation;Animals;Astrocytes;Biological;bioluminescence imaging;Brain;Cancer Patient;Cells;Characteristics;chemotherapeutic agent;Child;Childhood Brain Neoplasm;Childhood Glioma;ChIP-seq;Chromatin;clinical practice;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;combinatorial;Combined Modality Therapy;Complex;CRISPR/Cas technology;Data;Dependence;Development;Diagnosis;Diffuse intrinsic pontine glioma;Disease;DNA Damage;DNA Repair;DNA Repair Pathway;Drug Kinetics;early phase clinical trial;effective therapy;Elongation Factor;Epigenetic Process;experimental study;Expression Profiling;Foundations;Gene Expression;Gene Mutation;Genes;Genetic;Genetic Screening;Genetic Transcription;genome-wide;Goals;Growth;Histone H3;Histones;Human;improved;In Vitro;in vivo;Individual;inhibitor;inhibitor therapy;knock-down;Knock-out;Knowledge;Lysine;Malignant Childhood Neoplasm;Mediating;Methionine;Methylation;Mission;Modeling;Modification;Molecular;mutant;Mutation;National Institute of Neurological Disorders and Stroke;Nature;neoplastic cell;Nervous System;Nervous System Disorder;new therapeutic target;novel;novel therapeutic intervention;Oncogenic;Pathogenesis;patient derived xenograft model;patient screening;Patient-Focused Outcomes;Patients;pharmacologic;Polymerase;Positive Transcriptional Elongation Factor B;prevent;Property;protein H(3);Public Health;Radiation;Radiation enhancer;Radiation therapy;Radiation Tolerance;Rare Diseases;Research;research clinical testing;Resistance;RNA;RNA Polymerase II;Sequence Analysis;small hairpin RNA;small molecule;small molecule inhibitor;targeted treatment;Tertiary Protein Structure;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;therapeutically effective;therapy resistant;Toxic effect;Transcription Elongation;Transcription Initiation;Transcriptional Activation;transcriptional reprogramming;transcriptome;transcriptome sequencing;Treatment outcome;tumor;tumor growth;tumor progression;Xenograft procedure

PROJECT_TITLE: Targeting Transcriptional Elongation in Pediatric Glioma

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 1 Study Section[MCT1]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: PROJECT NARRATIVES. In the proposed supplement, we will examine whether Native Hawaiian/Pacific Islander (NH/PI) adults, who experience severe substance use disparities, increase their use of two or more substances (cigarettes, e-cigarettes, marijuana and/or alcohol) when experiencing discrimination and cultural trauma. Using daily questionnaires via a smartphone application, we will study in real-time the specific factors that influence substance use by these adults to cope with discrimination-related stress. Our results will reveal the burden of daily discrimination on addiction and unique cultural resilience among NH/PI adults that can reduce this burden.

PI_NAMEs: HUH, JIMI  (contact)

PROGRAM_OFFICER_NAME: DUNSTON, SHEBA KING

PROJECT_TERMS: Acute;addiction;Adult;adult of color;Affect;African American;Alcohols;American;Anxiety;Asian Americans;Asian Pacific Islander;behavioral response;Black, Indigenous, People of Color;Cigarette;Cognitive;combustible cigarette;Communities;community advisory board;comorbidity;coping;Cross-Sectional Studies;Custom;Data;design;digital;Discrimination;Disparity;Economic Factors;Electronic cigarette;Ethnic Origin;Ethnic Population;Etiology;Event;Exhibits;experience;Feasibility Studies;Feeling;flexibility;Focus Groups;Frequencies;Future;Gender;Health;health disparity populations;Indigenous;Individual;Inequity;intersectionality;Intervention;Language;Latinx;Linguistics;Literature;Marijuana;Masks;member;Methods;Minority;Modernization;Native Hawaiian;Native Hawaiian or Other Pacific Islander;Nature;novel;Outcome;Pacific Islander;parent grant;parent project;Parents;Participant;perceived discrimination;Persons;Phase;polysubstance use;Population;post-pandemic;preservation;Process;prospective;psychologic;Questionnaires;Race;racial population;racism;Recovery;recruit;Research;resilience;Resources;response;Review Literature;Risk;Role;Sample Size;Sampling;self esteem;smartphone application;social;social factors;Stress;Subgroup;substance use;Time;Trauma;United States National Institutes of Health;Variant

PROJECT_TITLE: The role of momentary acute discrimination and cultural resilience in polysubstance use among Native Hawaiian/Pacific Islander adults


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_CITY: Rockville

ORG_NAME: FEDERATION OF AMER SOC FOR EXPER BIOLOGY

PHR: Project Narrative The FASEB conference on Genetic Recombination and Genome Rearrangements brings together the world’s leading researchers investigating the mechanisms and regulation of genetic recombination and chromosome rearrangements. This field encompasses several topics directly relevant for the biology of aging, cell senescence, telomere maintenance, as well as to the mechanisms promoting age-related disease, including neurological disorders and cancer. Therefore, a mechanistic understanding of these processes is paramount for an improved understanding of premature aging, of cancer etiology, for the identification of critical biomarkers of various age-related conditions, and for developing novel strategies of treatments that are more efficacious and minimize side effects.

PI_NAMEs: MALKOVA, ANNA L (contact)

PROGRAM_OFFICER_NAME: GUO, MAX

PROJECT_TERMS: age related;age-related disease;aging related;aging related disease;Alkylating Agents;American;Area;Arizona;Biochemistry;Biological Markers;Biological Models;biological systems;Biology;Biology of Aging;Biophysics;Cancer Etiology;career;Cell Aging;Cells;Cellular biology;Chromatin Structure;Chromosomes;Collaborations;Communities;Complex;crosslink;Data;data exchange;Dedications;design;Discipline;Disease;DNA Damage;DNA Double Strand Break;DNA lesion;Environment;Environmental Exposure;environmental stressor;Equity;equity, diversity, and inclusion;Etiology;Event;Exposure to;Faculty;Feedback;forging;Fostering;Gamma Rays;Genetic;Genetic Crossing Over;Genetic Recombination;Genome;Genome Stability;Genomics;Goals;graduate student;homologous recombination;human disease;improved;innovation;innovative technologies;insight;interest;ionization;irradiation;Laboratories;Malignant Neoplasms;malignant neurologic neoplasms;Mediating;meetings;Meiotic Recombination;Mind;Molecular;Nervous System Disorder;novel strategies;Participant;Pathogenesis;Pathologic;Pathway interactions;Physiological;Postdoctoral Fellow;posters;Premature aging syndrome;Process;Productivity;programs;Proteins;Records;Regulation;repaired;Reporting;Research;Research Personnel;Rewards;Role;Scientist;senescence;Series;side effect;Signal Transduction;Societies;summer research;symposium;System;Techniques;technological innovation;Telomerase;telomere;Telomere Maintenance;Time;treatment strategy;Ultraviolet Rays;unpublished works;Woman

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development for Established Investigators and Conference Grants Study Section[AGCD-4]


NIH_SPENDING_CATS: Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Nutrition;Obesity

ORG_CITY: LEXINGTON

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: PROJECT NARRATIVE A major part of the mission of the International Society of Neurogastronomy (ISN) is to promote the study of flavor and its use to enhance the quality of human life, channeling our growing knowledge of neurogastronomy and chemosensory science into translational action needed to overcome the ways in which flavor preferences can contribute to unhealthy eating habits. ISN promotes cooperation between scientists and food professionals towards altering the balance of this equation in our culture. ISN’s annual meeting provides an important mechanism for facilitating the interactions between chemosensory scientists, neuroscientists, clinicians, nutritional scientists, agricultural scientists and food professionals needed to develop strategies for using flavor properly - strategies that are both practical and scientifically sound.

PI_NAMEs: MCCLINTOCK, TIMOTHY S (contact)

PROGRAM_OFFICER_NAME: SULLIVAN, SUSAN L

PROJECT_TITLE: International Society for Neurogastronomy Symposium

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: CLEVELAND

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

PHR: PROJECT NARRATIVE The Cleveland NeuroDesign Entrepreneurs Workshop is an innovative initiative designed to equip neurotechnology professionals with entrepreneurial skills, fostering the translation of cutting-edge research into practical applications. By propelling the development of novel neurotechnologies, the workshop contributes to our understanding of the human nervous system and accelerates the creation of advanced therapeutic solutions. In the long run, this can enhance the health and quality of life of individuals affected by neurological disorders, while reducing the societal burden of these illnesses.

PI_NAMEs: PULLIAM, CHRISTOPHER LEE (contact)

PROGRAM_OFFICER_NAME: GROSS, BROOKS ANDREW

PROJECT_TERMS: Academia;Academic Training;Acceleration;Active Learning;Address;Affect;Agreement;Animal Model;Award;broadening participation research;burden of illness;Businesses;Capital;career networking;Case Study;Clinical;Clinical Trials Design;cohort;commercialization;Communities;Complex;Coupled;design;Development;Development Plans;Education;educational atmosphere;Educational workshop;Effectiveness;empowerment;Engineering;Ensure;Entrepreneurship;experience;Faculty;follow-up;Fostering;Funding;Growth;Health;Health Technology;Healthcare;Human;improved;Individual;Industry;innovation;insight;Institution;Investments;Knowledge;Learning;lectures;Marketing;meetings;Mentorship;Minority;Modeling;Nervous System;Nervous System Disorder;neural;neurotechnology;novel;Outcome;outreach;Participant;Patient Care;patient oriented;Patients;practical application;pressure;Problem Solving;Process;programs;prototype;Quality of life;Recurrence;Research;research and development;Research Personnel;response biomarker;Risk;Role;Sales;Secure;Self Efficacy;skills;Students;Therapeutic;Training;Translating;translational health science;translational pipeline;Translations;Travel;Universities;Woman

STUDY_SECTION_NAME: Special Emphasis Panel[ZNS1 SRB-K (43)]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Eye Disease and Disorders of Vision;Pediatric

ORG_CITY: BLOOMINGTON

ORG_DEPT: PSYCHOLOGY

ORG_NAME: TRUSTEES OF INDIANA UNIVERSITY

ORG_STATE: IN

PHR: Project Narrative The proposed studies of the visual experience of infants are relevant to public health because impaired vision and visual learning have long term consequences across many domains of a healthy and successful life. Disrupted visual experience in infancy is evident in the continued risk in perceptual, cognitive and school achievements and is implicated in the nexus of disrupted visual learning and motor development of children with more general developmental disorders. Determining the expected and normative early visual input in infancy and its links to infant eye- movements and behaviors is expected to give rise to new diagnostics and behavioral interventions for at-risk infants.

PI_NAMEs: SMITH, LINDA B. (contact)

PROGRAM_OFFICER_NAME: WIGGS, CHERI

PROJECT_TERMS: Achievement;Age;Age Months;Behavior;behavior influence;Behavior Therapy;Birth;Child Development;Cognition;Cognitive;Development;developmental disease;Esthesia;experience;Eye;Eye Movements;Head;Head Movements;Home;Hour;Human;Image;infancy;Infant;Infant Behavior;Laboratories;Life;Link;Measures;Motion;Movement;novel diagnostics;Pattern;Persons;Play;Posture;Property;Public Health;Refractive Errors;Research;Risk;Role;Sampling;Schools;statistics;Structure;Testing;Vision;Visual;Visual impairment;visual learning;visual motor

PROJECT_TITLE: The Statistics of Infant First-Person Visual Experience

STUDY_SECTION: HCMF

STUDY_SECTION_NAME: Human Complex Mental Function Study Section[HCMF]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Immunization;Infectious Diseases;Orphan Drug;Pediatric;Prevention;Rare Diseases;Vaccine Related

ORG_CITY: BALTIMORE

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: Project Narrative Despite the availability of vaccines, diseases caused by Bordetella species continue to have a significant impact on the morbidity and mortality of humans and animals worldwide. There is an imperative need for an improved understanding of Bordetella evolution, diversity, and mechanisms of virulence to guide the informed development of next generation vaccines and therapeutics. The 14th International Bordetella Symposium will provide a forum for scientists, physicians, public health officials, regulators, and industry representatives to collaborate on the shared objective of realizing novel strategies for the control of diseases caused by Bordetella spp. in a diverse, equitable, and inclusive scientific environment.

PI_NAMEs: GESTAL, MONICA CARTELLE;SCANLON, KAREN  (contact)

PROGRAM_OFFICER_NAME: MULACH, BARBARA L

PROJECT_TERMS: Academy;Acellular Vaccines;Address;Advertisements;Africa;Age;Age Months;Agriculture;Animals;Atmosphere;Atrophic;Australia;Award;Basic Science;Bordetella;Bordetella avium;Bordetella bronchiseptica;Bordetella pertussis;Canada;Canis familiaris;career;career development;Caring;Case Study;Cells;Cessation of life;Child;Child Care;Circulation;Cities;Clinical;Collaborations;Communication;Communities;COVID-19;Czech Republic;Czechoslovakia;Dedications;Development;Disabled Persons;Discrimination;Disease;disorder control;disorder prevention;Economic Burden;Emerging Communicable Diseases;Ensure;Environment;Epidemiologist;Epidemiology;Equipment;Equity;equity, diversity, and inclusion;Europe;Event;Evolution;exhibitions;Exposure to;Family suidae;Financial Support;First Generation College Students;Fostering;Future;Gene Expression Regulation;Genomics;harassment;Health;Hospitalization;Human;human mortality;Hybrids;Immunity;improved;Incidence;Individual;Industry;Infant;Infection;interest;International;Internet;Japan;Knowledge;Life;Livestock;Location;Manufacturer;Medical;meetings;member;Microbiology;Minority;Mission;Molecular;Morbidity - disease rate;mortality;National Institute of Allergy and Infectious Disease;Nose;novel strategies;novel vaccines;online community;Oral;originality;Outcome;outreach;pathogen;Persons;Pertussis;Pertussis Vaccine;pet animal;Physicians;Population;posters;Preparation;prevent;priority pathogen;programs;Public Health;Reporting;Research;Research Personnel;respiratory pathogen;Respiratory Tract Infections;Rhinitis;Schedule;Science;scientific organization;Scientist;Series;Services;Site;skills;social media;Societies;South America;success;symposium;Technical Expertise;Therapeutic;transmission process;Travel;Turkey bird;Underrepresented Populations;Vaccinated;Vaccination;vaccination schedule;vaccine access;vaccine hesitancy;Vaccines;Veterinarians;virtual;Virulence;web site;Woman;Work;World Health Organization;Zoonoses

PROJECT_TITLE: 14th International Bordetella Symposium

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 LK-D (J1)]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Depression;Mental Health;Mental Illness;Neurosciences

ORG_CITY: Jupiter

ORG_NAME: MAX PLANCK FLORIDA CORPORATION

PHR: Contact PD/PI: Wright, Emily Clarissa PROJECT NARRATIVE In this proposal, I aim to apply these two sensors combined with fiber-photometry to optically measure behaviorally driven serotonin release in an anxiogenic serotonin circuit with high temporal and spatial resolution. This information will be made publicly available and become fundamental data to guide future research with the sLight and iSeroSnFr biosensors. I will use these sensors to answer previously unapproachable questions about functional role of serotonin in an anxiogenic circuit and mechanistically address gaps in SSRI efficacy. Project Narrative Page 7

PI_NAMEs: WRIGHT, EMILY CLARISSA (contact)

PROGRAM_OFFICER_NAME: VAN'T VEER, ASHLEE VICTORIA

PROJECT_TERMS: Acute;Address;Adult;Androgen Receptor;Animals;Anti-Anxiety Agents;Anxiety;Anxiety Disorders;anxiety-like behavior;anxious;Attenuated;attenuation;Auditory;Behavior;behavior measurement;behavior test;Behavioral;behavioral response;Biosensor;Castration;Chronic;conditioned fear;Consensus;Data;deprivation;Development;Diagnosis;dorsal raphe nucleus;Engineering;experimental study;Female;Fiber;Fluoxetine;genetic manipulation;Gonadal Steroid Hormones;Guidelines;Image;in vivo;Injections;insight;Knock-out;male;Maps;Measures;Mental disorders;Microdialysis;millisecond;Mus;neural circuit;Neurons;Neurosecretory Systems;Optics;optogenetics;Outcome;Pathway interactions;Patients;Pattern;Performance;pharmacologic;Photometry;Physiological;Population;prepuberty;Prevalence;promoter;Protocols documentation;Reaction;Reporting;Research;Resolution;response;Rewards;Role;Selective Serotonin Reuptake Inhibitor;sensor;Series;Serotonergic System;Serotonin;Serotyping;Sex Differences;Signal Transduction;social defeat;Social Interaction;social stress;Stimulus;Stress;stressor;Structure of terminal stria nuclei of preoptic region;suicidal risk;technology validation;Testing;Testosterone;Time;Transgenic Organisms;Work

PROJECT_TITLE: Imaging Dynamics in Anxiogenic Serotonin Circuitry


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Pharmacoequity, a term coined by researchers within our Center for Pharmaceutical Policy and Prescribing (CP3), refers to the goal of ensuring that all individuals, regardless of race/ethnicity, socioeconomic status, or availability of resources, have access to the highest quality medications required to manage their health needs. The proposed 3rd Annual Pharmacoequity Conference will feature presentations centered on key research findings, new methodologies, and policy solutions that utilize and apply pharmacoequity principles to ensure the equitable access to pharmacotherapy to all persons. This conference provides a unique platform for which engaged stakeholders from payer groups, health systems, and research communities can gain insight on how to address and apply pharmacoequity principles and tools within their respective fields.

PI_NAMEs: GELLAD, WALID F. (contact)

PROGRAM_OFFICER_NAME: WALKER, CHIVONNE L

PROJECT_TITLE: Pharmacoequity Conference

STUDY_SECTION_NAME: Special Emphasis Panel[ZHS1 HSR-T (01)]


NIH_SPENDING_CATS: Disability Research;Neurosciences;Physical Injury - Accidents and Adverse Effects;Traumatic Head and Spine Injury

ORG_STATE: CA

PHR: Project Narrative Traumatic brain injury (TBI) and spinal cord injury (SCI) are a major public health burden that often lead to lifelong impairment and disability. The National Neurotrauma Society (NNS), largely through its annual Symposium, is a critical translational research resource for sharing the latest advances in the neurotrauma field, with the ultimate goal of improving the treatments available to patients. Ongoing support for this annual meeting ensures a major national investment in advancing and innovating neurotrauma research and in the career development of trainees, with a focus on opportunities for increasing and retaining diversity in trainees and faculty in the neurotrauma field.

PI_NAMEs: FERGUSON, ADAM R (contact)

PROGRAM_OFFICER_NAME: LAVAUTE, TIMOTHY M

PROJECT_TERMS: Achievement;Affect;American;Americans with Disabilities Act;Area;Award;Basic Science;Biomedical Research;career;career development;Clinical;clinical care;Clinical Research;Collaborations;Communication;Congresses;cost;Critical Care;Data;Dedications;design;Development;disability;Disabled Persons;Education;Educational workshop;Emerging Technologies;Ensure;Faculty;Fostering;Foundations;Funding;Future;gender diversity;Geography;Goals;graduate student;Health Personnel;healthcare burden;Impairment;improved;Individual;innovation;interest;International;Investments;Joints;Knowledge;meetings;Mentors;Nervous System Trauma;Neurologic;Neurosciences Research;next generation;Oral;Participant;Patient Care;Patients;peer;Persons;Postdoctoral Fellow;posters;programs;Public Health;racial diversity;Recording of previous events;recruit;Reproducibility;Research;Research Personnel;Resource Sharing;San Francisco;Scholars Program;Scientist;Societies;spinal cord and brain injury;Surgeon;symposium;technological innovation;Technology;tool;Training;Training Support;Translating;Translational Research;Translations;Traumatic Brain Injury;Travel;undergraduate student;Underrepresented Minority;Underrepresented Populations;underserved students;United States National Institutes of Health;Universities;Update;Woman;Work

PROJECT_TITLE: 41st National Neurotrauma Society (NNS) Annual Symposium 2024 - Future Classics of Neurotrauma


NIH_SPENDING_CATS: Behavioral and Social Science;Biotechnology;Neurosciences

ORG_CITY: East Greenwich

ORG_NAME: GORDON RESEARCH CONFERENCES

PHR: Project Narrative The 2024 Gordon Research Conference and Gordon Research Seminar on Optogenetic Approaches to Understanding Neural Circuits and Behavior will bring together leading experts and junior investigators, tool designers and tool users, experimentalists and theorists with the goal of fostering scientific exchange in the rapidly growing field of optogenetics. The conference program will provide multiple forums in which attendees will share unpublished results and discuss the latest technological developments, the strengths and limitations of the tools, and how they can be applied to addressing questions about brain and behavior and ultimately to treating human disorders. As such, the conference will serve to foster new ideas and collaborations and will propel the next generation of young scientists toward new applications and discoveries.

PI_NAMEs: RAMIREZ, STEVE  (contact)

PROGRAM_OFFICER_NAME: CHEN, DAOFEN

PROJECT_TERMS: Address;Animals;Appointment;awake;Behavior;bench to bedside;Biomedical Engineering;Brain;career;career development;cell type;clinical application;Collaborations;collaborative environment;Communities;Cytoskeleton;Data Analyses;Dedications;Development;Discipline;Disease;Ensure;Evaluation;Experimental Designs;experimental study;Face;Faculty;Feedback;Fiber Optics;Fostering;Gene Delivery;Gene Targeting;Genetic Transcription;Goals;Growth;Hand;Hour;Human;human disease;innovation;interest;International;Italy;Learning;Light;Link;meetings;Memory;Mentors;Mentorship;Methods;Microscopy;Monitor;neural circuit;Neural Pathways;Neurobiology;neuromechanism;Neuromodulator;Neurons;Neurotransmitters;next generation;open source;Optics;optogenetics;Outcome;Outcome Study;Participant;Pathway interactions;Phosphotransferases;Postdoctoral Fellow;posters;Potassium;Process;programs;Research;Research Design;Research Personnel;Scientist;sensor;sight restoration;Students;support network;symposium;Techniques;Technology;technology development;theories;Time;tool;Translations;Underrepresented Populations;Woman;Women's Group;Work

PROJECT_TITLE: 2024 Optogenetic Approaches to Understanding Neural Circuits and Behavior Gordon Research Conference and Seminar


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

PHR: Project Narrative Both the Gordon Research Conference (GRC) and Gordon Research Seminar (GRS) entitled “Extracellular vesicles: structure and function, technology development, and clinical application" will bring together a diverse group of basic and clinical junior and senior investigators to address the biogenesis of extracellular vesicles (EVs), the mechanisms via which these EVs control (patho)physiological processes, and their diagnostic and therapeutic potential. The research presented and discussed at the GRC and GRS likely will contribute to the development of new extracellular vesicle-based treatments for a wide spectrum of diseases including cancer, infectious diseases, and chronic diseases of the heart, lung and brain.

PI_NAMEs: LANGUINO, LUCIA R. (contact)

PROGRAM_OFFICER_NAME: HAPPEL, CHRISTINE MARIE

PROJECT_TERMS: Address;American;Animal Model;Area;Atmosphere;Automobile Driving;Biogenesis;Biological;Biological Markers;biological systems;Biology;Brain Diseases;career;Cellular biology;Chronic Disease;Clinical;clinical application;clinical development;Clinical Investigator;Clinical Protocols;Clinical Trials;Collaborations;Communicable Diseases;Communication;Communities;design;Detection;Development;Diagnostic;Disease;disease phenotype;diversity and inclusion;DNA;Engineering;Environment;Etiology;Evaluation;extracellular vesicles;Face;Fees;Funding;Goals;graduate student;healing;Health;Heart Diseases;Heterogeneity;Hour;Human;human disease;Immune;Individual;injured;intercellular communication;International;Knowledge;Lipids;Location;Lung Diseases;Maine;Malignant Neoplasms;Mediating;meetings;Minority;Neurobiology;novel;Participant;pathogen;peer;Performance;Physiological Processes;Play;Postdoctoral Fellow;pre-clinical;Process;Productivity;Proteins;Publishing;Research;Research Personnel;RNA;Role;Science;Scientist;Societies;Structure;symposium;technology development;Therapeutic;Tissues;trafficking;translational potential;Translational Research;Translations;Treatment Efficacy;unconscious bias;Visit;Woman

PROJECT_TITLE: 2024 Extracellular Vesicles Gordon Research Conference and Gordon Research Seminar

STUDY_SECTION_NAME: Special Emphasis Panel[ZTR1 CG-2 (02)]


ED_INST_TYPE: SCHOOLS OF NURSING

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE Despite calls for change in how care is delivered to older adults in long-term post-acute care, poor quality of care continues to plague millions of older adults who reside in these settings. There continues to be important gaps in research to inform how care delivery can be improved in long-term care systems globally. The purpose of this conference is to build a research agenda that will lead to safer, higher quality, more accessible, and equitable long-term post-acute care.

PI_NAMEs: ALEXANDER, GREGORY L. (contact)

PROGRAM_OFFICER_NAME: CHANEY, KEVIN

PROJECT_TITLE: A Roadmap for Research: The International Summit on Innovation and Technology in Care of Older People (IS-ITCOP)


NIH_SPENDING_CATS: Aging

ORG_NAME: AMERICAN FEDERATION FOR AGING RESEARCH

PHR: Project Narrative The Beeson Program supports talented scientists in aging research prepared to take an active leadership role in transformative change that will lead to improved research or healthcare outcomes. The proposed series of annual meetings support the major goals of the Beeson program, which are to support career development, advance leadership skills and linking (external) mentors to the Beeson Scholars. The annual meetings encourage and support these goals, while at the same time facilitating the development of a collective identity and cohesiveness among the Scholars

PI_NAMEs: GILL, THOMAS MICHAEL;GILMORE-BYKOVSKYI, ANDREA L;YAFFE, KRISTINE  (contact)

PROGRAM_OFFICER_NAME: BAKOS, ALEXIS DIANE

PROJECT_TERMS: Address;Advisory Committees;Aging;American;Award;Awareness;Back;care outcomes;career;career development;Career Mobility;Clinical;Collaborations;Communication;Communities;design;Development;Discipline;Disparate;Early identification;Faculty;Fostering;Funding;Funding Agency;Future;Geriatrics;Goals;Grant;Growth and Development function;Hour;improved;innovation;Institution;interdisciplinary approach;Interest Group;K-Series Research Career Programs;Leadership;Link;medical specialties;meetings;Mentors;Mentorship;Mission;Nurses;older adult;Older Population;outreach;Participant;physical therapist;Physicians;Play;Privatization;programs;Psychologist;Research;research and development;Research Personnel;Resources;Role;role model;Schedule;Scientist;senior faculty;Series;skill acquisition;skills;Structure;symposium;synergism;Talents;Time;tool;Training;United States National Institutes of Health;virtual

PROJECT_TITLE: Paul B. Beeson Emerging Leaders Career Development Awards in Aging Annual Meeting


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Urologic Diseases

ORG_CITY: LINTHICUM

ORG_NAME: AMERICAN UROLOGICAL ASSOCIATION

PHR: 2024 AUA OFFICE OF RESEARCH BASIC SCIENCES SYMPOSIUM  “Spatial Biology in Benign and Malignant Urologic Disease” PROJECT NARRATIVE/PUBLIC HEALTH RELEVANCE STATEMENT Understanding spatial biology in benign and malignant urologic disease is crucial to advancing urologic research and improving clinical care, and it is essential that the urology community, especially trainees, early- career physician-scientists, and researchers be provided with accessible opportunities to gain understanding of new knowledge and significant recent advances in these fields and leverage it towards improvements for patient diagnosis and treatment. The goal of the 2024 AUA Basic Sciences Symposium is to bring together pioneers in spatial biology to educate and foster interaction between urologists, other physicians, and researchers to provide new insights into epigenetic priming, differentiation, and gene regulation with implications for tumor staging and grading in urologic disease. The uniqueness of the 2024 Basic Sciences Symposium at the AUA Annual Meeting is not only that it brings the latest advancements in research to the world’s largest gathering of urologists and urology researchers, but also that the Program Chairs prioritized consideration of racial, ethnic, gender/gender identity, sexual orientation, nationality, cultural, religious, age, (dis)ability, career stage, and socioeconomic backgrounds in accordance with the Diversity, Equity, and Inclusion Statement of the AUA Office of Research: Research Education Conferences, and Communications Committee (RECCC).

PI_NAMEs: RIORDAN, CHRISTINE  (contact)

PROGRAM_OFFICER_NAME: CONAGE-POUGH, JASON EDWARD

PROJECT_TERMS: Age;American;Architecture;Area;Award;Basic Science;Benign;Biology;career;career development;Caring;Cells;Cellular Assay;Clinical;clinical care;clinical practice;Communication;Communities;Dedications;Development;Diagnosis;Diagnostic Neoplasm Staging;disability;Discipline;Disease;Doctor of Philosophy;education research;Epigenetic Process;epigenomics;equity, diversity, and inclusion;Ethnic Origin;Exhibits;Fostering;Foundations;Freezing;Future;Gender;Gender Identity;Gene Expression Regulation;Genotype;Goals;graduate student;Grant;Healthcare;Heterogeneity;improved;Individual;insight;interest;International;Knowledge;Learning;lectures;Link;Malignant - descriptor;Medical center;meetings;Memorial Sloan-Kettering Cancer Center;mid-career faculty;Nationalities;new technology;next generation;Participant;Patients;Phenotype;Physicians;posters;Principal Investigator;Privatization;programs;Prostatic Diseases;public health relevance;Race;Religion;Request for Applications;Research;Research Personnel;Science;Scientist;Sex Orientation;socioeconomics;Specimen;symposium;Technology;Tissues;transcriptomics;Translational Research;Travel;tumor;urinary;urologic;Urologic Diseases;Urologist;Urology;Work

PROJECT_TITLE: American Urological Association (AUA) Basic Science Symposium (BSS) on Spatial Biology in Benign and Malignant Urologic Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-7 (J3)]


NIH_SPENDING_CATS: Kidney Disease

ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: Project Narrative This application for a diversity supplement will help Dr. Justin Conner develop his skills to become an independent biomedical investigator while contributing to our understanding of the cytoprotective functions of the antioxidant protein peroxiredoxin 6 during renal ischemia/reperfusion injury.

PI_NAMEs: VAZQUEZ MEDINA, JOSE P (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TERMS: Acute Renal Failure with Renal Papillary Necrosis;Acylation;Acyltransferase;Affect;Antioxidants;Biology;Catalytic Domain;Cell Death;Cell membrane;Clinical;Cytoprotection;Disease;Endothelial Cells;Enzymes;glutathione peroxidase;Goals;Hydrogen Peroxide;Inflammatory;Iron;Ischemia;Kidney;Knock-in Mouse;Knockout Mice;Lysophosphatidylcholines;Modeling;Organoids;oxidant stress;Patients;peroxiredoxin;Phospholipase A2;Phospholipids;Point Mutation;post-doctoral training;Process;Proteins;renal ischemia;repair enzyme;Reperfusion Injury;Reperfusion Therapy;Research Personnel;Role;Signal Transduction;skills

PROJECT_TITLE: The Biology of Peroxiredoxin 6


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Dissemination and Implementation Research;Rare Diseases;Urologic Diseases

PHR: 2024 AUA OFFICE OF RESEARCH UROLOGIC ONCOLOGY RESEARCH SYMPOSIUM  “Implementation Science: Translating Clinical Studies into Practice”  PROJECT NARRATIVE/PUBLIC HEALTH RELEVANCE STATEMENT Understanding implementation science in benign and malignant urologic disease is crucial to advancing urologic research and improving clinical care, and it is essential that the urology community, especially trainees, early-career physician-scientists, and researchers be provided with accessible opportunities to gain understanding of new knowledge and significant recent advances in these fields and leverage it towards improvements for patient diagnosis and treatment. The goal of the 2024 AUA Urologic Oncology Research Symposium is to bring together pioneers in implementation science to educate and foster interaction between urologists, other physicians, and researchers. The uniqueness of the 2024 Urologic Oncology Research Symposium at the AUA Annual Meeting is not only that it brings the latest advancements in research to the world’s largest gathering of urologists and urology researchers, but also that the Program Chairs prioritized consideration of racial, ethnic, gender/gender identity, sexual orientation, nationality, cultural, religious, age, (dis)ability, career stage, and socioeconomic backgrounds in accordance with the Diversity, Equity, and Inclusion Statement of the AUA Office of Research: Research Education Conferences, and Communications Committee (RECCC).

PI_NAMEs: KUGELMAN-TONOS, JOHANNY  (contact)

PROGRAM_OFFICER_NAME: CHOLLETTE, VERONICA

PROJECT_TERMS: Age;American;Area;Award;Basic Science;Benign;career;career development;Caring;Chicago;Clinical;clinical care;clinical practice;Clinical Research;Clinical Trials;Clinical Trials Design;Communication;Communities;Dedications;Development;Diagnosis;disability;Discipline;Disease;Doctor of Philosophy;education research;equity, diversity, and inclusion;Ethnic Origin;evidence base;Exhibits;Faculty;Fostering;Foundations;Funding;Future;Gender;Gender Identity;Goals;graduate student;Grant;Healthcare;implementation science;implementation strategy;improved;Individual;insight;interest;International;Kansas;Knowledge;Learning;lectures;Malignant - descriptor;Malignant neoplasm of urinary bladder;Medical center;meetings;Mentors;Methods;mid-career faculty;Modeling;Nationalities;new technology;next generation;Oncology;Operative Surgical Procedures;Participant;Patients;Physicians;posters;Principal Investigator;Privatization;professor;programs;public health relevance;Race;Records;Religion;reproductive;Request for Applications;Research;Research Personnel;Risk;Scientist;Sex Orientation;Smoking Cessation Intervention;socioeconomics;symposium;theories;Translating;Travel;United States National Institutes of Health;Universities;urinary;urologic;Urologic Diseases;Urologic Oncology;Urologist;Urology;Work

PROJECT_TITLE: American Urological Association (AUA) Urologic Oncology Research Symposium on "Implementation Science: Translating Clinical Studies into Practice"

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 PCRB-9 (J1)]


NIH_SPENDING_CATS: Biomedical Imaging;Cancer

PHR: Project Narrative Cancer is an increasing threat to public health with poor patient outcomes. Radionuclide Theranostics for the management of cancer is an exponentially growing field with a concrete notion on patient’s quality of life while maximally extending the survival. Our aim is to bring the key stakeholders towards achieving that goal.

PI_NAMEs: ZAN, ELCIN  (contact)

PROGRAM_OFFICER_NAME: CAPALA, JACEK

PROJECT_TERMS: Academia;Acceleration;Address;Awareness;career;Clinical;Clinical Trials;Collaborations;Combined Modality Therapy;Communities;Data;data sharing;Department of Energy;Diagnostic;Disabled Persons;Discipline of Nuclear Medicine;efficacious treatment;Endocrinology;Ensure;Environment;Feedback;Fostering;Funding;Future;Goals;graduate student;Grant;Growth;Hybrids;Immunology;improved;Institution;interest;Interruption;Intervention;Jordan;Laboratories;Maine;Malignant Neoplasms;Medical;Medical Oncology;meetings;Mentors;Molecular Target;next generation;Normal tissue morphology;novel;Oncology;Patient-Focused Outcomes;Patients;peer;Pharmacologic Substance;Physicians;Physics;Postdoctoral Fellow;posters;pre-clinical;Privatization;programs;Public Health;Quality of life;Radiation Oncology;Radiochemistry;Radioisotopes;Radiometry;Radiopharmaceuticals;Research;Research Personnel;scale up;Science;Scientist;Senior Scientist;side effect;skills;Students;success;supportive environment;symposium;theranostics;Therapeutic;Time;Toxic effect;Translating;translational scientist;Translations;tumor;Underrepresented Minority;United States National Institutes of Health;Update;vector;Woman

PROJECT_TITLE: 2024 Radionuclide Theranostics for the Management of Cancer Gordon Research Conference and Gordon Research Seminar


PHR: Project Narrative Neurons are remarkable cells that execute functions ranging from simple sensing and reporting on the environment to enabling cognition, functions that neurons must accomplish against unique challenges for shape, connection, maintenance and communication. The devastating developmental and late onset neurodegenerative diseases (including Alzheimer’s disease, Parkinson’s disease, ALS) that result from neuronal dysfunction or loss underscore the critical importance of understanding the mechanisms that underlie and sustain neuron health. The Cell Biology of the Neuron Gordon Research Conferences will have a major impact on galvanizing ideas emerging from state-of-the-art neuronal cell biology technologies and experimental outcomes by: i) broadening mechanistic understanding of the critical roles of internal neuronal functionalities relevant to human aging, health, and neurological disease, ii) inspiring design of novel therapeutic strategies to combat neuronal developmental dysfunction and disease, and iii) promoting the career growth of a diverse population of students and junior investigators through customized training and networking opportunities.

PI_NAMEs: DRISCOLL, MONICA A. (contact)

PROGRAM_OFFICER_NAME: LEENDERS, MIRIAM

PROJECT_TITLE: 2024 Cell Biology of the Neuron Gordon Research Conference and Seminar


NIH_SPENDING_CATS: Bioengineering;Hearing Loss;Machine Learning and Artificial Intelligence;Neurosciences

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative: Deafness is the most common and arguably the most socially isolating sensory impairment, with the World Health Organization estimating that over 360 million people worldwide have moderate to profound hearing loss. Although the physiological causes of most forms of deafness are incompletely understood, it is clear that changes to the delicate structures of the peripheral auditory system, such as the cochlear hair cells normally responsible for the high sensitivity and exquisite frequency selectivity of hearing, are mostly to blame. A deeper scientific understanding of peripheral auditory function at both the structural and molecular level therefore remains critical to reducing the devastating impact of hearing loss on both individuals and society.

PI_NAMEs: GROSH, KARL  (contact)

PROGRAM_OFFICER_NAME: CYR, JANET

PROJECT_TERMS: absorption;Area;Audiology;Auditory;Auditory Physiology;Auditory system;Award;Biological;Biomechanics;Biophysics;Canada;Chicago;Classification;Cochlea;Communities;Computer Models;cost;Data;deaf;deafness;Denmark;Diagnosis;Educational workshop;Engineering;Environment;Frequencies;Funding;Germany;Goals;Greece;Hair Cells;Hearing;hearing impairment;Hearing Tests;image processing;improved;Individual;insight;Institution;Interdisciplinary Study;interest;International;Japan;Knowledge;Learning;lectures;Location;Machine Learning;mathematical model;Mathematics;Mechanics;member;men;Methods;Michigan;Modeling;Molecular;Netherlands;neural;Neurosciences;Paper;Participant;Peripheral;Persons;Physiological;Physiology;Postdoctoral Fellow;Productivity;Publishing;Research;Research Personnel;research study;Science;Senior Scientist;Sensory impairment;Services;sharing platform;Social isolation;Societies;Sociology;Structure;Students;symposium;System;Talents;Techniques;Technology;Travel;Underrepresented Populations;United Kingdom;United States;United States National Institutes of Health;Universities;vestibular system;Woman;Work;World Health Organization

PROJECT_TITLE: Mechanics of Hearing Workshop - 2024

STUDY_SECTION_NAME: Special Emphasis Panel[ZDC1 SRB-Y (58)]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Autoimmune Disease;Cardiovascular;Heart Disease;Pediatric;Rare Diseases

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: The 14th International Kawasaki Disease Symposium will provide an opportunity for trainees and leading scientists and clinicians across multiple disciplines from around the world to present the latest research and clinical care for Kawasaki disease, the leading cause of acquired heart disease in children throughout most of the world. This will lead to further scientific collaborations and improved clinical care worldwide for children with Kawasaki disease. Given that this is a cardiovascular illness that affects children that likely has an infectious cause, and that the International Kawasaki Disease Symposium’s mission is to turn research observations into health solutions, this is in alignment with the priorities of NHLBI, NICHD, NIAID and NCATS.

PI_NAMEs: TREMOULET, ADRIANA H (contact)

PROGRAM_OFFICER_NAME: BURNS, KRISTIN

PROJECT_TERMS: Acceleration;Acute;Address;Affect;Aneurysm;Authorization documentation;barrier to care;Canada;Cardiology;Cardiovascular Diseases;Cardiovascular system;career development;Caring;Cessation of life;Child;Childhood;Clinical;clinical care;Collaborations;Congestive Heart Failure;Coronary Aneurysm;Coronary artery;Dedications;Diagnosis;Disabled Children;Discipline;Disease;Education;Epidemiologist;Ethnic Origin;Family;Funding;Generations;Goals;graduate student;Health;Heart Diseases;Immunology;improved;Inflammatory;International;Journals;Knowledge;Lesion;Letters;Life;Medical Students;meetings;Mentors;Mission;Morbidity - disease rate;mortality;Mucocutaneous Lymph Node Syndrome;Myocardial Infarction;Myocardium;National Center for Advancing Translational Sciences;National Heart, Lung, and Blood Institute;National Institute of Allergy and Infectious Disease;National Institute of Child Health and Human Development;Observational Study;Outcome;pandemic disease;Patient Care;patient subsets;Patients;Peer Review;Persons;Phase;Public Health;Publications;Publishing;Race;recruit;Request for Proposals;Research;Research Personnel;Risk;Science;Scientist;senior faculty;Sudden Death;symposium;Syndrome;Thrombosis;Travel;Underrepresented Populations;United States;United States National Institutes of Health;Vascular Diseases;Work

PROJECT_TITLE: 14th Annual International Kawasaki Disease Symposium 2024

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-L (J2)]