NIH_SPENDING_CATS: Asthma;Lung

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: PROJECT NARRATIVE A subset of Asthma patients with specific inflammatory profile (neutrophils) in their sputum, with scarring of the airways, develop resistance to therapies and are at higher risk of death. This project addresses the exact contribution of the inflammatory mediator named “LIGHT” in lethal asthma. It aims to identify the mechanistic underpinnings of severe asthma, explain why patients become resistant to standardized therapies, and test a novel therapy neutralizing LIGHT to treat this severe refractory disease.

PI_NAMEs: HERRO, RANA ELIAS (contact)

PROGRAM_OFFICER_NAME: MINNICOZZI, MICHAEL

PROJECT_TERMS: Actins;Address;Airway Disease;Airway Fibrosis;airway inflammation;airway remodeling;Airway Resistance;Allergens;Area;Asthma;asthma model;asthmatic;asthmatic patient;Automobile Driving;B-Lymphocytes;cell type;Cells;Chemotactic Factors;Chemotaxis;Chronic;Coculture Techniques;Collagen;combinatorial;comparative efficacy;conventional therapy;CSF2 gene;CXCL2 gene;Data;Deposition;Development;eosinophilic asthma;Epithelial Cells;epithelial to mesenchymal transition;Epithelium;Exhibits;experimental study;Extracellular Matrix Proteins;Fibroblasts;gain of function;Genes;Goals;Heterogeneity;high risk;Human;human data;human disease;idiopathic pulmonary fibrosis;IL17 gene;Individual;Inflammation;Inflammation Mediators;Inflammatory;Knowledge;Leukocytes;Light;Lung;Mediating;Mediator;member;Migration Assay;Modeling;mortality;mortality risk;mouse model;Mus;muscle hypertrophy;Names;neutrophil;Neutrophil Infiltration;Neutrophilia;novel;novel therapeutics;Onset of illness;Organoids;Outcome;Pathogenesis;Pathogenicity;Pathologic;Patients;Phenotype;Predisposition;Production;Proliferating;receptor;Refractory Disease;Resistance;Resistance development;Role;Severities;Signal Transduction;single-cell RNA sequencing;Smooth Muscle;Source;Sputum;Standardization;Steroid Resistance;Steroids;Stromal Cells;Symptoms;T-Cell Activation;T-Lymphocyte;Testing;Th2 Cells;Therapeutic Intervention;therapy resistant;Time;TNF gene;transcriptomics;Transforming Growth Factor beta;Up-Regulation;Work

PROJECT_TITLE: The TNF Superfamily Control of Pathological Remodeling Associated with Severe Asthma

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IIDB-K(57)]


ADMINISTERING_IC: ES

ARRA_FUNDED: N

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: American Indian or Alaska Native;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Prevention;Racial and Ethnic Minority Health Research

ORG_CITY: SOUTH PORTLAND

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_STATE: ME

PHR: The goal of the Community College Consortium for Health and Safety Training (CCCHST) is to help the nation be better prepared to prevent and to respond to hazardous materials incidents through the training of instructors serving workers from business and industry; students from community and tribal colleges and technical schools, including first responders; transitioning military; and members of community-based and faith-based organizations in targeted communities. CCCHST will make NIEHS-approved training nationally available through over 100 CCCHST organizational members, prepared through a Train-the-Trainer model program, to offer hazardous materials and disaster preparedness instruction in nearly all states of the nation. Over 250,000 workers, students, and citizens, prepared by CCCHST instructors over a five-year period, will understand how to protect themselves and their communities when working with hazardous chemicals and hazardous situations.

PI_NAMEs: NASH, WILLIAM KESTER (contact)

PROGRAM_OFFICER_NAME: BEARD, SHARON

PROJECT_TERMS: Area;Attention;base;Businesses;career;Certification;Chemicals;Collaborations;Communities;community college;community organizations;Community Workers;cost effective;demographics;Development;Disasters;Education;Educational Curriculum;Educational Technology;Educational workshop;Electronic Mail;Emergency response;Employment;Employment Opportunities;Enrollment;Evaluation;Exposure to;Faith;Faith-based organization;Family;Family member;first responder;Future;Generations;Goals;Grant;Guam;Hazardous Chemicals;hazardous materials disaster;hazardous materials worker;Hazardous Substances;Hazardous Waste;Hazardous Waste Sites;Health;high school;High School Student;Hour;Human Resources;Industry;Instruction;instructor;International;Internet;Learning;learning materials;Left;Medial;member;military family;Military Personnel;Mission;Modeling;National Institute of Environmental Health Sciences;Natural Disasters;Participant;Performance;prevent;programs;Public Sector;Puerto Rico;quality assurance;Readiness;Reporting;Research Institute;response;Safety;Services;Students;symposium;Teacher Professional Development;technical college;Telephone;Trainers Training;Training;Training Programs;Transportation;tribal college;tribal Nation;Universities;university student;Veterans;volunteer;waste treatment;Workplace

PROJECT_TITLE: NPETE's Community College Consortium for Health and Safety Training


ADMINISTERING_IC: AG

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: JACKSONVILLE

ORG_NAME: MAYO CLINIC  JACKSONVILLE

ORG_STATE: FL

PI_NAMEs: SORANNO, ANDREA  (contact)

PROJECT_TERMS: Affinity;Age-associated memory impairment;Aging;Alzheimer's Disease;Amino Acids;Amyloid beta-Protein;Apolipoprotein E;apolipoprotein E-3;apolipoprotein E-4;Astrocytes;Automobile Driving;Binding;Biochemical;Biological Assay;Biology;Blood Vessels;Brain;brain cell;Bypass;cell type;Cells;Collaborations;Complement;Complex;Cryoelectron Microscopy;Data;Disease Progression;Equilibrium;Event;experimental study;Fluorescence;Fluorescence Spectroscopy;Foundations;functional outcomes;Human;induced pluripotent stem cell;innovation;insight;Investigation;Knock-in Mouse;Length;Libraries;Lipid Binding;Lipids;Lipoproteins;Liposomes;Measurement;Methods;Microglia;Modeling;Molecular;Molecular Conformation;molecular dynamics;monomer;mouse model;Negative Staining;neurotoxicity;novel strategies;particle;Pathogenicity;Pathology;Physiological;Property;Protein Fragment;Protein Isoforms;Proteins;Risk;Role;single molecule;structural biology;Structural Models;Structure;Testing;Time;Work

PROJECT_TITLE: ApoE isoform-specific structure: Insights on biology and pathobiology


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Biotechnology;Brain Disorders;Gene Therapy;Genetics;HIV/AIDS;Infectious Diseases;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Although small-molecule antiretroviral therapy (ART) drugs effectively control an HIV infection, there are drawbacks to their use, including their inability to prevent HIV-associated neurological disease in many patients. We have previously shown that expression of the exceptionally broad and potent antibody-like inhibitor eCD4, expressed from a gene-therapy vector, can protect from challenge with and often control infection of HIV model viruses. Here, we will determine if we can apply this approach to effectively treat the neurological consequences of HIV infection.

PI_NAMEs: FARZAN, MICHAEL R. (contact);MANKOWSKI, JOSEPH L

PROGRAM_OFFICER_NAME: DALEY, WILLIAM PATRICK

PROJECT_TERMS: adeno-associated viral vector;adenovirus mediated delivery;Affinity;AIDS dementia;Animals;Antibodies;antiretroviral therapy;Astrocytes;Behavior;Binding;Binding Sites;Biological;Biological Markers;Biological Products;Blood - brain barrier anatomy;Brain;brain tissue;CCR5 gene;cell type;Cells;Central Nervous System;Central Nervous System Diseases;Central Nervous System Infections;Cerebrospinal Fluid;Clinical Trials;co-infection;Compensation;Consequences of HIV;cost;CXCR4 gene;detection limit;Disease Progression;DNA cassette;Drug Kinetics;efficacy study;experience;experimental study;expression vector;fitness;Gene Transduction Agent;HIV;HIV anti-retroviral;HIV Infections;HIV-associated neurocognitive disorder;Human;Immunoglobulin G;Infection;Infection Control;Infusion procedures;inhibitor;Intramuscular;Intravenous;Laboratories;Left;Life;Lymphocyte;Macaca;Macaca mulatta;Macaca nemestrina;Macrophage;Measures;Mediating;Methods;Microglia;Modeling;Monitor;monocyte;Mus;Muscle;neuroAIDS;Neurofilament Proteins;Neurologic;neurotropic;neutralizing antibody;nonhuman primate;Pathway interactions;Patient Compliance;Patients;peptidomimetics;Persons;Pharmaceutical Preparations;Plasma;Predisposition;Prevalence;prevent;promoter;Protein Secretion;receptor;receptor expression;Recombinant adeno-associated virus (rAAV);Regimen;Reproducibility;Research Personnel;Safety;Severities;Side;side effect;simian human immunodeficiency virus;SIV;SIV encephalitis;Skeletal Muscle;small molecule;social stigma;Testing;Therapeutic;Toxic effect;Viral Load result;Viremia;Virus

PROJECT_TITLE: eCD4-Mediated Control of SIV Infection in the Brain

STUDY_SECTION: HIVD

STUDY_SECTION_NAME: HIV Immunopathogenesis and Vaccine Development Study Section[HIVD]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Breastfeeding, Lactation and Breast Milk;Clinical Research;Maternal Health;Mental Health;Microbiome;Neurosciences;Nutrition;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Women's Health Research

ORG_CITY: ROCHESTER

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF ROCHESTER

ORG_STATE: NY

PHR: At birth, the infant intestines (gut) are exposed to and colonized by thousands of different types of bacteria. Recent studies have hinted at the potential for these early colonizers to influence brain development and behavior. It is not known what chemical messages are sent by the gut bacteria to cause such changes in the developing brain. It is also unknown when during rapid changes in infant brain development these messages have their greatest impact. Our study is designed to identify factors during pregnancy that influence the earliest gut colonization in infants, what chemical messages are created by the bacteria, and how the presence and timing of such signals impacts brain development.

PI_NAMEs: GILL, STEVEN R. (contact);O'CONNOR, THOMAS G;SCHEIBLE, KRISTIN

PROGRAM_OFFICER_NAME: KING, ERIN MICHELE

PROJECT_TERMS: 4 year old;Age;age related biomarkers;Anabolism;Anxiety;Area;Bacteria;Behavior;Biochemical;Biological;Birth;Blood specimen;Brain;Central Nervous System;Chemicals;Child;Clinical;Clinical Research;Cognition;cohort;Collection;Communication;Data;design;Development;early onset;endophenotype;Enteric Nervous System;Event;Exposure to;feeding;First Pregnancy Trimester;Future;Goals;gut bacteria;gut colonization;gut microbiome;gut microbiota;gut-brain axis;Human Milk;Immune;imprint;improved;indexing;Individual Differences;Infant;infant gut microbiome;Intervention;Intestines;Life;Link;maternal anxiety;Maternal Exposure;maternal imprint;maternal microbiome;maternal microbiota;maternal risk;Measures;metabolomics;metagenome;Metagenomics;microbiome;microbiome composition;microbiota;Modeling;Molecular;mother nutrition;Mothers;neglect;Neurobiology;Neurocognitive;neurodevelopment;neuroimaging;Neurotransmitters;Newborn Infant;nutrition;offspring;Outcome;parent grant;Participant;Pathway interactions;Peripheral;Phase;Placenta;postnatal;postnatal development;postnatal period;pre-clinical;Pregnancy;prenatal;prenatal exposure;prenatal influence;Prevention strategy;Production;prospective;Reporting;Risk Factors;Role;Sampling;Shapes;Signal Transduction;Source;stool sample;Taxonomy;Testing;Third Pregnancy Trimester;Umbilical Cord Blood;vaginal fluid;vaginal microbiome

PROJECT_TITLE: Neurobiological and neurocognitive consequences of diverse microbiome functional trajectories

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


PI_NAMEs: HOLTZMAN, DAVID M. (contact)

PROJECT_TERMS: 25-hydroxycholesterol;abeta deposition;Affect;Age;age related;Aging;aging related;Agonist;Alzheimer's Disease;Amyloid beta-Protein;Amyloid deposition;Apolipoprotein E;Astrocytes;Biochemical;Bioinformatics;Biological Markers;Biology;Brain;Brain region;Cells;Cholesterol;Cholesterol Esters;Cholesterol Homeostasis;Coculture Techniques;Collaborations;cytokine;Data;Defect;Demyelinations;density;E protein;Gene Expression;Genotype;glial activation;Histologic;Human;human induced pluripotent stem cells;Immune;Immunomodulators;immunoregulation;improved;In Vitro;in vivo;induced pluripotent stem cell;Inflammasome;Inflammation;Inflammatory Response;Injections;Innate Immune Response;Knock-in;Knock-in Mouse;Knockout Mice;Link;lipid metabolism;lipidomics;Lipids;Lipoproteins;Literature;Mass Spectrum Analysis;Measures;Mediating;metabolomics;Microglia;Mixed Function Oxygenases;Modeling;Mus;Nerve Degeneration;Neuroglia;Neurons;neuropathology;neurotoxicity;particle;Pathogenesis;Pathology;Phenotype;Play;Process;Production;Property;Protein Isoforms;Proteomics;Regulation;remyelination;response;reverse cholesterol transport;Role;sex;Signal Transduction;Source;Sterols;Stimulus;Structure;tau Proteins;Tauopathies;Variant;Work

PROJECT_TITLE: APOE effects on glial lipid metabolism and 25-hydroxycholesterol: Effects on aging and AD-related pathology


ADMINISTERING_IC: EY

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Genetics;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: GALVESTON

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

ORG_STATE: TX

PHR: NARRATIVE Sirt6 is a NAD-dependent histone H3 lysine 9 (H3K9) and H3K56 deacetylase which represses many aging processes. We propose studies to understand the role of Sirt6 in retinal ganglion cell injury and optic nerve degeneration in glaucoma.

PI_NAMEs: LIU, HUA  (contact)

PROGRAM_OFFICER_NAME: HENLE, STEVEN JOHN

PROJECT_TERMS: Abbreviations;Acceleration;Acute;Age;age acceleration;Aging;aging process;anti aging;Axon;axon injury;axon regeneration;beta-Galactosidase;Biochemistry;Biology;Blindness;blood glucose regulation;CDKN2A gene;Cell Aging;Cell Death;cell injury;Cell Physiology;Cell Survival;Cessation of life;chromatin immunoprecipitation;Chronic;Clinic;Complex;conditional knockout;corneal epithelial wound healing;Data;Deacetylase;Development;DNA Repair;Electroretinography;Endothelial Cells;Endothelium;Exhibits;Face;Functional disorder;ganglion cell;Ganglion Cell Layer;gene repression;Genes;Genetic;Genomic Instability;Glaucoma;Glial Fibrillary Acidic Protein;Histone Deacetylase;Histone H3;Homologous Gene;Image;Immunohistochemistry;Impairment;Inflammation;Injury;Inner Nuclear Layer;Kidney;knock-down;Knock-out;Knockout Mice;Knowledge;life span;Link;Lysine;Mediating;Mediator;member;mitochondrial dysfunction;Modeling;Molecular;Molecular Biology Techniques;mouse model;Mus;Nerve Degeneration;Neurofilament-H;Neuropathy;neuroprotection;Neurosciences;Nicotinamide adenine dinucleotide;nitrosative stress;non-invasive imaging;novel;novel strategies;novel therapeutics;Nuclear;Optic Disk;Optic Nerve;optic nerve disorder;Optical Coherence Tomography;Optics;overexpression;Oxidative Stress;Pathologic;pathological aging;Pathology;Phenotype;Physiologic Intraocular Pressure;Physiology;Play;Positioning Attribute;Predisposition;premature;Premature aging syndrome;prevent;Prevention;Propidium Diiodide;Proteins;Publications;Reperfusion Therapy;Repression;Research Priority;response;Retina;Retinal Diseases;retinal ganglion cell degeneration;Retinal Ganglion Cells;retinal ischemia;Risk Factors;Role;Scanning Electron Microscopy;senescence;senescence associated secretory phenotype;Series;Sirtuins;Synapsins;Testing;Therapeutic Intervention;transcription factor;Vision research;Visual evoked cortical potential;Visual impairment;Yeasts

PROJECT_TITLE: Neuroprotective Role of Sirt6 in Glaucoma

STUDY_SECTION: DPVS

STUDY_SECTION_NAME: Diseases and Pathophysiology of the Visual System Study Section[DPVS]


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision

ORG_CITY: AUGUSTA

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: AUGUSTA UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Secondary cataract is the most common complication after cataract surgery. This study is intended to understand the fundamental role of inflammation and oxidation in the progression of this complication.

PI_NAMEs: FAN, XINGJUN  (contact)

PROGRAM_OFFICER_NAME: ARAJ, HOUMAM H

PROJECT_TERMS: Address;Affect;Animal Model;Aqueous Humor;Autocrine Communication;beta catenin;Biogenesis;Biology;capsule;Cataract;Cataract Extraction;Cell Communication;Cell Culture Techniques;cell growth;Chronic;Chronic Disease;cohort;Colorado;Communication;Complication;cytokine;Data;Disease;Endocrine;Epithelial Cell Proliferation;Epithelial Cells;epithelial to mesenchymal transition;Epithelium;exosome;extracellular vesicles;Fibrosis;high risk;Human;human tissue;In Vitro;in vivo;in vivo Model;Inflammation;Inflammatory;Investigation;Kinetics;lens;Light;Mediating;migration;mouse model;Mus;novel;Operative Surgical Procedures;Oryctolagus cuniculus;oxidation;Oxidation-Reduction;Oxidative Stress;Pathogenesis;Pathogenicity;Pathologic;Pathway interactions;Physiological;Pilot Projects;Play;prevent;Primary Cell Cultures;Process;Proliferating;Recording of previous events;Regulatory Pathway;Research;Residual state;Role;Signal Pathway;Signal Transduction;Signaling Molecule;Stimulus;Testing;therapeutic target;TNF gene;trafficking;transcriptome sequencing;transdifferentiation;Transforming Growth Factor beta;Universities;Visual Acuity;WNT Family Gene;WNT Signaling Pathway

PROJECT_TITLE: Mechanisms of lens epithelium fibrosis and its relevance to posterior capsule opacification

STUDY_SECTION: BDE

STUDY_SECTION_NAME: Biology and Development of the Eye Study Section[BDE]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Chronic Pain;Pain Research

ORG_CITY: FULLERTON

ORG_DEPT: CHEMISTRY

ORG_NAME: CALIFORNIA STATE UNIVERSITY FULLERTON

ORG_STATE: CA

PHR: Project Narrative There has been little innovation in the development of the new analgesic drugs that target novel mechanisms of action. We will focus on the structure-activity relationship studies, biological evaluation, behavioral testing, and optimization of the new dual inhibitors of soluble epoxide hydrolase and fatty acid amide hydrolase enzymes, to increase the levels of anti-inflammatory and analgesic metabolites in the body. Through in vitro and in vivo studies, we aim to demonstrate that the designed dual inhibitors are effectively inhibiting both aforementioned enzymes simultaneously, are metabolically stable, and can produce pain relief in a rat model of chronic inflammatory pain with the potential to become novel, safe, and effective non-opioid treatments for patients suffering from chronic pain.

PI_NAMEs: PECIC, STEVAN  (contact)

PROGRAM_OFFICER_NAME: CUPIT, PAULINE

PROJECT_TERMS: Absence of pain sensation;Acute inflammatory pain;Acute Pain;addiction;Adult;Adverse effects;American;Analgesics;analog;Animals;Anti-Inflammatory Agents;Antiinflammatory Effect;antinociception;behavior test;Behavioral;behavioral pharmacology;benzothiazole;Biological;Biological Assay;Biomedical Research;California;Chronic inflammatory pain;chronic pain;chronic pain management;Clinical Research;Computer Assisted;Coupled;daily pain;Data;design;Development;Diagnosis;disability;Dose;Drug Design;drug development;drug discovery;Drug Interactions;Drug Kinetics;Ensure;Enzymes;Epoxide hydrolase;Evaluation;FAAH inhibitor;fatty acid amide hydrolase;Formalin;Foundations;Funding;Future;Generations;Goals;Grant;Health Professional;Hispanic-serving Institution;Hydrolase;Hypersensitivity;improved;in silico;In Vitro;in vivo;Inflammation;inhibitor;Injections;innovation;intraperitoneal;Investigation;Ketoprofen;Laboratories;Lead;Libraries;Ligands;Link;Liver Microsomes;Mechanics;Medical;Metabolic;Modeling;Modification;Molecular;multidisciplinary;new therapeutic target;non-opioid analgesic;Non-Steroidal Anti-Inflammatory Agents;novel;Opioid;Opioid agonist;Pain;Pain management;pain relief;Patients;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacophore;Physical Dependence;Play;pre-clinical;preclinical development;programs;Property;Protocols documentation;Rattus;Reporting;Research;Resources;Role;side effect;small molecule;Structure;Structure-Activity Relationship;success;Testing;Therapeutic;tool;underrepresented minority student;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Designed Multiple Ligands as Non-opioid Analgesics for Treating Chronic Pain


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Eye Disease and Disorders of Vision;Genetics;Neurosciences

ORG_CITY: CAMBRIDGE

ORG_DEPT: BIOLOGY

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

PHR: PROJECT NARRATIVE An understanding of the fundamental mechanisms that control animal development and behavior is key to an understanding of many aspects of human health and disease. This project aims to reveal molecular mechanisms that mediate behavioral responses by the experimentally tractable roundworm Caenorhabditis elegans to the environmental stress of oxygen deprivation (hypoxia) and the environmental cue of multichromatic light (color). C. elegans shares many genetic, molecular and cellular features with more complicated animals, including humans, and these studies should provide insights concerning both fundamental aspects of human biology and disease processes as diverse as blindness, heart disease and cancer.

PI_NAMEs: HORVITZ, H ROBERT (contact)

PROGRAM_OFFICER_NAME: STEPANEK, LAURIE ELIZABETH

PROJECT_TERMS: absorption;Affect;Afferent Neurons;Anatomy;Animals;Bacteria;base;Behavior;Behavior Control;Behavioral;behavioral response;Biological;biological adaptation to stress;Biological Assay;Biology;Blindness;Caenorhabditis elegans;Cell Lineage;Cell membrane;Cell Physiology;cell type;Cells;Color;color detection;Control Animal;Cues;Cystic Fibrosis;deprivation;Development;Discrimination;Disease;egg;Environment;environmental stressor;Epithelial Cells;epithelial Na+ channel;experimental study;Exposure to;Eye;feeding;gene discovery;Gene Expression Profile;Genes;Genetic;genetic analysis;Genetic Screening;Goals;Grant;Health;heart damage;Heart Diseases;Homeostasis;Human;Human Biology;human disease;Hypertension;Hypoxia;hypoxia inducible factor 1;insight;interest;Intestines;Ions;Ischemia;Light;Link;Liquid substance;Locomotion;Malignant Neoplasms;Mammalian Cell;Mammals;Mechanical Stimulation;mechanical stimulus;Mediating;Metalloproteases;Molecular;Molecular Genetics;Muscle;Mutation;Myocardial Infarction;Nematoda;Nervous System;neural;neural circuit;neuromuscular system;Neurons;Neuropeptides;neurotransmission;Nonsense-Mediated Decay;novel;Opsin;Organ;Organism;Oxygen;Pathologic;Pathway interactions;Peptide Hydrolases;Photoreceptors;physiologic stressor;Physiological;Physiological Processes;Physiology;preference;Prevention;Process;protein function;Proteins;receptor;Regulation;renal damage;response;RNA;Sensory;Signal Transduction;single-cell RNA sequencing;Sodium;Specific qualifier value;Specificity;Stress;Stroke;Structure of retinal pigment epithelium;System;Testing;therapeutic target;Tissues;Touch sensation;Transcript;Visual

PROJECT_TITLE: Genetic Analysis of Nematode Egg Laying and Co-regulated Behavioral Systems

STUDY_SECTION: SYN

STUDY_SECTION_NAME: Synapses, Cytoskeleton and Trafficking Study Section[SYN]


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Childhood Obesity;Clinical Research;Complementary and Integrative Health;Conditions Affecting the Embryonic and Fetal Periods;Endocrine Disruptors;HIV/AIDS;Infectious Diseases;Maternal Health;Maternal Morbidity and Mortality;Nutrition;Obesity;Pediatric;Pediatric - AIDS;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Women's Health Research

ORG_CITY: NEW YORK

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE There are high rates of both HIV infection and obesity in pregnant women in South Africa. Dolutegravir, an integrase inhibitor antiretroviral drug, has been associated with excess weight gain and metabolic derangements. We will study the impact of dolutegravir taken during pregnancy, a critical time during which exposures may influence long term health, on the metabolic health of women living with HIV and their young children in South Africa

PI_NAMEs: ABRAMS, ELAINE JANINE (contact);JAO, JENNIFER ;MYER, BENJAMIN LANDON

PROGRAM_OFFICER_NAME: MAJJI, SAI PRASANNA

PROJECT_TERMS: Address;Adipocytes;adiponectin;Adipose tissue;Affect;Air;Anti-Inflammatory Agents;Anti-Retroviral Agents;antiretroviral therapy;Arachidonic Acids;C-Peptide;Child;Child Health;Chronic;Clinical;cohort;comorbidity;Complex;critical period;Data;design;Docosahexaenoic Acids;Dyslipidemias;Eicosanoids;Eicosapentaenoic Acid;Energy Intake;Energy Metabolism;Enrollment;Equilibrium;excessive weight gain;Exposure to;Fatty Acids;fetal;Fibrosis;First Pregnancy Trimester;Functional disorder;Funding;gestational weight gain;ghrelin;Goals;Health;HIV;HIV Infections;Homeostasis;Human Milk;Hunger;Hypertrophy;Hypoxia;in utero;Inflammation;Inflammatory;insight;Insulin;Insulin Resistance;Integrase Inhibitors;Interleukin-6;Intervention;intestinal fatty acid binding protein;Leptin;Life;Life Cycle Stages;Link;Lipids;Lysophosphatidylcholines;Maternal Health;maternal outcome;Measures;Metabolic;Metabolic Diseases;metabolomics;Mitochondria;Mothers;N-3 polyunsaturated fatty acid;Neonatal;Obesity;obesity in pregnancy;obesogen;obesogenic;Omega-3 Fatty Acids;Omega-6 Fatty Acids;Overweight;Pathway interactions;Persons;Pharmaceutical Preparations;Phospholipids;Play;Plethysmography;Polyunsaturated Fatty Acids;poor health outcome;Population;postpartum health;Postpartum Period;postpartum weight;Pregnancy;pregnant;Pregnant Women;prenatal exposure;prepregnancy;Public Health;recruit;Regimen;Research Infrastructure;Research Project Grants;Research Support;Respiration;Rest;Risk Reduction;Role;Satiation;scale up;Series;Shapes;South Africa;subcutaneous;Techniques;Time;Triglycerides;Umbilical Cord Blood;United States National Institutes of Health;Weight;Weight Gain;Woman;Women's Health;α-Melanocyte stimulating hormone

PROJECT_TITLE: Obesogenic origins of maternal and child metabolic health involving dolutegravir (ORCHID)


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Dementia;Neurodegenerative;Neurosciences

PI_NAMEs: WU, LONG-JUN  (contact)

PROJECT_TERMS: Abeta clearance;Address;Affect;Age Months;Age-associated memory impairment;Aging;aging related;Alleles;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Amyloid;Amyloid beta-Protein;amyloid pathology;Apolipoprotein E;apolipoprotein E-3;apolipoprotein E-4;Astrocytes;behavioral phenotyping;Biochemical;Biochemistry;Bioinformatics;Biological Markers;Biology;Biometry;Blood Vessels;Brain;Breeding;cell type;Cells;cerebrovascular;Cerebrovascular system;Cognition;cognitive function;Collaborations;Communities;Data;data management;Development;Disease;Disease associated microglia;Electron Microscopy;Exhibits;Future;Gene Expression Profile;Genes;Genetic Determinism;Glial Fibrillary Acidic Protein;Homeostasis;Human;human induced pluripotent stem cells;Image;Impairment;improved;in vivo;Innate Immune Response;innovative technologies;interdisciplinary approach;Knock-in;Late Onset Alzheimer Disease;lipid metabolism;lipidomics;Liquid substance;Measures;Mediating;Metabolism;metabolomics;Microdialysis;Microglia;Modeling;molecular phenotype;mouse model;multidisciplinary;multiple omics;Mus;Nerve Degeneration;Neuroglia;neuroinflammation;neuropathology;neurotoxic;novel;particle;Pathogenesis;Pathogenicity;Pathology;Pathway interactions;Phase;Plasma;Play;Property;Protein Isoforms;Proteomics;Resources;response;response to injury;Risk;Role;Sampling;Senile Plaques;sex;single-cell RNA sequencing;specific biomarkers;Stains;Structural Models;Structure;synaptic function;synergism;tau Proteins;Testing;Therapeutic;two-photon;Work

PROJECT_TITLE: Astrocytic and microglial apoE in aging and AD


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Prevention;Racial and Ethnic Minority Health Research;Serious Mental Illness;Social Determinants of Health;Substance Misuse

ORG_CITY: HOUSTON

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF HOUSTON

PHR: Project Narrative There is a public health need to develop novel, culturally adapted interventions to reduce alcohol consumption among Latinx hazardous drinkers with comorbid clinical anxiety. The proposed R01 study will draw upon National Institutes of Health (NIH) treatment development guidelines (Stage 1) to translate and innovate past work to address a major public health priority. Specifically, we propose to develop (Phase IA) and test (Phase IB) the effectiveness of a brief, integrated, single-session, computer-based, culturally adapted personalized feedback intervention (PFI) designed to enhance knowledge regarding adverse anxiety-alcohol interrelations, increase motivation and intention to reduce hazardous drinking, and reduce positive attitudes and intention regarding anxiety-related alcohol use among Latinx hazardous drinkers with anxiety within community-based health clinics.

PI_NAMEs: ZVOLENSKY, MICHAEL J. (contact)

PROGRAM_OFFICER_NAME: WHITAKER, DAMIYA EVE

PROJECT_TERMS: acceptability and feasibility;Address;alcohol abuse therapy;Alcohol consumption;alcohol misuse;alcohol misuse prevention;alcohol related consequences;alcohol use disorder;Alcohols;Anxiety;anxiety management;anxiety reduction;anxiety symptoms;Area;Attitude;Basic Science;Behavior Therapy;biobehavior;brief intervention;Caring;Clinic;clinical anxiety;Clinical Trials Design;Community Health;comorbidity;compare effectiveness;Computers;coping;cost;COVID-19;culturally appropriate intervention;Data;demographics;design;Development;Disease;Disparity;drinking;Effectiveness;effectiveness evaluation;effectiveness testing;effectiveness trial;ethnic discrimination;Expectancy;experience;Feedback;Female;Focus Groups;follow-up;Frequencies;Goals;Guidelines;hazardous drinking;Health;health care settings;health disparity;health disparity populations;health inequalities;Health Services Accessibility;Impairment;improved;innovation;Intention;Intervention;intervention effect;intervention refinement;Knowledge;Latinx;Latinx population;Literature;male;Mediating;Mediator;Modeling;Motivation;National Institute on Alcohol Abuse and Alcoholism;novel;optimism;Outcome;Participant;personalized normative feedback;Phase;point of care;Population;Populations at Risk;Prevalence;psychoeducation;Public Health;public health priorities;Randomized;randomized, clinical trials;Randomized, Controlled Trials;recruit;Reporting;Research;Research Project Grants;Research Support;Sampling;Severities;Standardization;Strategic Planning;Symptoms;Testing;therapy design;therapy development;Translating;Treatment Cost;Underserved Population;United States;United States National Institutes of Health;Work

PROJECT_TITLE: Latinx Hazardous Drinkers with Clinical Anxiety: Effectiveness Trial of a Personalized Normative Feedback Intervention


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Contraception/Reproduction;Infertility;Prevention;Women's Health Research

ORG_CITY: CHICAGO

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE There continues to be a severe shortage of physician scientists who hail from the field of Obstetrics and Gynecology, yet there is a growing number of pressing women’s reproductive health issues that would greatly benefit from targeted investigation. Since 2005, in our first 3 funding periods of the Northwestern University WRHR Program, we have successfully developed and fostered the growth of an outstanding mentored career development program highly conducive to transitioning Obstetricians and Gynecologists to become independent investigators. Here, we continue to build on our successes and strive to continue and improve this Program, thus generating the highest quality of successful OBGYN trained physician scientists.

PI_NAMEs: BULUN, SERDAR E. (contact)

PROGRAM_OFFICER_NAME: MAZLOOMDOOST, DONNA

PROJECT_TERMS: African American;Area;Award;Basic Science;Behavior Therapy;Benchmarking;biobehavior;Biological Markers;Cancer Center;career development;Clinical Research;Clinical Sciences;Clinical Trials;Contraceptive methods;Department chair;Discipline of obstetrics;Faculty;Family Planning;Fellowship Program;Female;Fostering;Funding;Genetic;Goals;Grant;Gynecologic Oncology;Gynecologist;Gynecology;health equity;Hispanic;Home;Infertility;Institution;Laboratories;Leadership;Manuscripts;Maternal-fetal medicine;medical schools;Medicine;member;Mentors;Names;National Heart, Lung, and Blood Institute;National Institute of Child Health and Human Development;National Institute of Diabetes and Digestive and Kidney Diseases;National Institute of Mental Health;National Institute on Minority Health and Health Disparities;oncofertility;Peer Review;Pelvis;programs;Public Health;Publishing;Reconstructive Surgical Procedures;reproductive;Reproductive Endocrinology;Reproductive Sciences;Research;Research Infrastructure;Research Methodology;Research Personnel;Research Training;Residencies;Site;social science research;Specialist;Techniques;Training;Training Programs;Translational Research;United States National Institutes of Health;United States National Library of Medicine;Universities;Women's Health;women's reproductive health

PROJECT_TITLE: Research Career Development in Obstetrics and Gynecology


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Nutrition;Obesity;Physical Activity;Prevention

ORG_CITY: Aurora

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Given the limited success of our current lifestyle approaches to treat overweight and obesity, it is important to rigorously evaluate novel and practicable strategies to increase weight loss in adults. The optimal time of day to exercise is a question that is receiving increasing attention in the media and lay press, with articles touting the weight loss benefits of morning exercise without supporting scientific evidence. The proposed research is relevant to public health because it will provide a robust dataset regarding the impact of morning versus evening exercise on weight loss and compensatory behaviors, and will allow clinicians and public health experts to advise patients on the optimal time of day to exercise to promote weight loss.

PI_NAMEs: CATENACCI, VICTORIA A (contact)

PROGRAM_OFFICER_NAME: MARUVADA, PADMA

PROJECT_TERMS: Adherence;Adult;Aerobic Exercise;Affect;Attention;Attenuated;attenuation;Behavior;Behavioral;Body Composition;Body mass index;Body Weight;Body Weight Changes;Body Weight decreased;Burn injury;Calories;Categories;Characteristics;circadian;Circadian Rhythms;Compensation;Cues;Data;Data Analyses;Data Set;design;Desire for food;Development;Diet;Dose;doubly-labeled water;energy balance;Energy Intake;Energy Metabolism;Ensure;Equilibrium;Exercise;exercise intervention;exercise prescription;exercise training;Exhibits;Expenditure;Fatty acid glycerol esters;food craving;Hunger;Indirect Calorimetry;Individual;innovation;insight;Intake;Intervention;intervention effect;Life Style;Literature;Measures;Methods;novel;Nutritional;Obesity;obesity treatment;Overweight;Participant;Pathway interactions;Patients;Pattern;Phase;Physical activity;Physiological;prevent;primary endpoint;primary outcome;prospective;Public Health;Randomized;randomized trial;Regulation;Research;response;sedentary;Sleep;success;Time;total energy expenditure;trial comparing;Weight;Weight Gain

PROJECT_TITLE: Does When You Exercise Matter? A Randomized Trial Comparing the Effect of Morning versus Evening Aerobic Exercise on Weight Loss and Compensatory Behaviors

STUDY_SECTION: HSDO

STUDY_SECTION_NAME: Human Studies of Diabetes and Obesity Study Section[HSDO]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Dementia;Genetics;Neurodegenerative;Neurosciences;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

PI_NAMEs: KANEKIYO, TAKAHISA  (contact)

PROJECT_TERMS: Acceleration;Affect;Age;Age Months;age related;Aging;Alleles;Alzheimer's Disease;Alzheimer's disease risk;Amyloid;Amyloid beta-Protein;amyloid pathology;ApoE knockout mouse;Apolipoprotein E;apolipoprotein E-3;Astrocytes;Atherosclerosis;beta amyloid pathology;Biochemistry;Bioinformatics;Biological Markers;Biology;Biometry;Blood - brain barrier anatomy;Blood Vessels;Brain;Brain imaging;brain parenchyma;Breeding;Cell model;Cell Physiology;cell type;Cells;Cerebral Amyloid Angiopathy;cerebrovascular;Cerebrovascular Circulation;Cerebrovascular Disorders;Cerebrovascular system;Cognition;cognitive function;cognitive performance;Collaborations;comparative;Coupling;data management;Development;DNA cassette;Elderly;Ensure;Excision;Genes;Genotype;gliovascular;glycation;Goals;Homeostasis;Human;human induced pluripotent stem cells;hypercholesterolemia;Immune response;Immune system;Impaired cognition;Individual;innovation;Knock-in Mouse;Knock-out;Knockout Mice;lipid metabolism;lipid transport;lipidomics;Lipoproteins;Liquid substance;LoxP-flanked allele;Measures;Mediating;Metabolism;metabolomics;Microglia;Modeling;Molecular;molecular phenotype;Molecular Profiling;mouse model;multiple omics;Mus;Nerve Degeneration;Neuroglia;neuroinflammation;neuropathology;novel;Outcome;oxidation;particle;Pathogenesis;Pathogenicity;Pathologic;Pathway interactions;Pericytes;Phase;Phenotype;Plasma;Play;promoter;Property;Protein Isoforms;Proteomics;Resources;Risk Factors;Role;Sampling;Severities;single-cell RNA sequencing;Smooth Muscle Myocytes;Statistical Data Interpretation;Structural Models;Study models;Testing;Vascular Cognitive Impairment;white matter damage;White Matter Hyperintensity

PROJECT_TITLE: Impact of vascular apoE in aging and AD


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_DEPT: NEUROSCIENCES

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: PROJECT NARRATIVE Eye movements play a central role in how we interact with the world; looking, inspecting, navigating, and reaching all rely on integrating how our eyes are moved with what the brain does with the images formed on the back of the eye. This project will enable a new line of research to uncover the brain mechanisms that allow large and small eye movements to support visual processing of spatial information. Disruption of these eye movements by disease or brain injury may be a sensitive indicator of cognitive dysfunction and an unrecognized component of sensory, developmental, and learning disorders.

PI_NAMEs: PURPURA, KEITH P. (contact)

PROGRAM_OFFICER_NAME: FLANDERS, MARTHA C

PROJECT_TERMS: active vision;Area;area V1;Back;Behavior;Brain;Brain Injuries;Communication;Cues;Custom;design;developmental disease;Disease;Electrophysiology (science);experience;experimental study;extrastriate visual cortex;Eye;Eye Movements;feasibility research;fovea centralis;Frequencies;gaze;Grant;Human;Image;Impaired cognition;Implant;information gathering;information processing;interest;Learning Disorders;luminance;Maps;Methods;Microelectrodes;Modeling;Monkeys;Motion;Motor;natural flow;neural;neural patterning;Noise;nonhuman primate;novel;oculomotor;Output;Pattern;Pattern Recognition;Performance;Phase;Play;Population;prevent;Psychophysics;real-time images;Recurrence;Research;Resolution;Retina;retinal imaging;retinal neuron;Role;Saccades;sample fixation;Sampling;Sensory;Sensory Disorders;sensory stimulus;Shapes;Signal Transduction;Source;spatiotemporal;Stimulus;Structure;Technology;Testing;Texture;Time;Uncertainty;Vision;Visual;visual information;visual processing;visual tracking;Work

PROJECT_TITLE: Role of fixational eye movements and saccades in processing spatial information in V1-V2-V4 networks


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Effects of Indoor Air Pollution;Human Genome;Lead Poisoning;Neurosciences;Pediatric;Social Determinants of Health

ORG_CITY: PHILADELPHIA

ORG_DEPT: PATHOLOGY

ORG_NAME: THOMAS JEFFERSON UNIVERSITY

ORG_STATE: PA

PHR: This application proposes to study how early life variations in quality of maternal care and social environment contribute individually and interact to influence adult cognitive and behavioral outcomes from developmental exposure to lead. Proposed studies will also examine alterations in brain epigenetic profiles and gene expression patterns in different brain regions, and how these biological effects relate to the expression of cognitive and behavioral deficits following exposures to lead and different early life experiences. A goal of this work is to provide information on the extent to which social and environmental interventions might mitigate the cognitive and behavioral damage produced by developmental lead exposure and to establish a biological framework that support these interventions.

PI_NAMEs: SCHNEIDER, JAY S (contact)

PROGRAM_OFFICER_NAME: HOLLANDER, JONATHAN

PROJECT_TERMS: Academic achievement;Adult;Adverse event;adverse outcome;Affect;Amygdaloid structure;Association Learning;base;Behavior;Behavior Therapy;Behavioral;behavioral outcome;Biological;blood lead;Brain;Brain region;Caregivers;caregiving;Caring;Child;Child Rearing;Classification;Cognitive;Communities;Complex;Data;Deterioration;Development;differential expression;Digestion;disabled;DNA Methylation;Environment;environmental enrichment for laboratory animals;Environmental Exposure;Environmental Impact;environmental intervention;environmental Pb exposure;Environmental Risk Factor;epidemiologic data;Epigenetic Process;executive function;experience;experimental study;exposure route;Exposure to;Female;frontal lobe;Gene Expression;Gene Expression Profile;Genes;Genetic Transcription;Goals;high risk;Hippocampus;Home environment;Immunoprecipitation;improved outcome;Individual;Infant;Intervention;Lead;lead exposure;Lead levels;Learning;Life;Life Experience;Long-Term Effects;low socioeconomic status;male;Mediating;member;Memory;Methylation;methylome;Modification;Mothers;neural;neurodevelopment;Neurodevelopmental Deficit;neurotoxicity;Neurotoxins;offspring;Outcome;Paint;Perinatal;Play;Poison;Poisoning;Population;postnatal;Public Health;Research;resilience;response;restriction enzyme;Role;sex;social;Social Development;Social Environment;social factors;social interventions;Socioeconomic Status;Testing;Time;transcriptome;transcriptome sequencing;transcriptomics;translation factor;Variant;Water;Weaning;Work

PROJECT_TITLE: Early Life Environment Modifies Behavioral, Epigenetic, and Transcriptional Outcomes from Developmental Lead Exposure

STUDY_SECTION: BRLE

STUDY_SECTION_NAME: Biobehavioral Regulation, Learning and Ethology Study Section[BRLE]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Digestive Diseases;Infectious Diseases;Microbiome;Nutrition;Physical Injury - Accidents and Adverse Effects

ORG_CITY: MEMPHIS

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF TENNESSEE HEALTH SCI CTR

ORG_STATE: TN

PHR: Public exposure to radiation due to large-scale radiation incidents is a rising global concern, but there are no FDA-approved therapeutics for radiation injury. Therefore, we propose to conduct studies to uncover the cellular and molecular mechanisms involved in radiation-induced innate immunity dysfunction. The outcome of these studies will identify a new medical countermeasure to treat radiation injury by targeting innate immune dysfunction.

PI_NAMEs: RAO, RADHAKRISHNA  (contact)

PROGRAM_OFFICER_NAME: WINTERS, THOMAS A

PROJECT_TERMS: alpha-Defensins;Anti-Bacterial Agents;anti-microbial peptide;Attenuated;Bacteria;base;Biology;Bone Marrow;Cell Physiology;Cell secretion;Clinical;Colitis;cryptdin;Data;Defensins;Diet;Dose;Down-Regulation;dysbiosis;Effectiveness;Endotoxemia;Enterobacteriaceae;Epithelial Cells;Epithelium;Exposure to;FDA approved;fecal transplantation;Fibroblasts;Functional disorder;gastrointestinal;gastrointestinal epithelium;Goals;Growth;gut dysbiosis;gut microbiota;Homeostasis;Human;Immune;Immune System Diseases;Impairment;Inflammatory Response;insect defensin A;intestinal crypt;intestinal epithelium;Intestinal Mucosa;Intestines;Ionizing radiation;irradiation;Knockout Mice;Mediating;medical countermeasure;Messenger RNA;metatranscriptome;microbiota;microbiota composition;Molecular;Morbidity - disease rate;mortality;mouse model;Mucosal Immune System;Mucosal Immunity;Mucositis;Mucous Membrane;multiorgan injury;Mus;Natural Immunity;novel;Outcome Study;Paneth Cells;pathobiont;pathogen;Pathogenesis;Pathway interactions;Peptides;Predisposition;Production;Protein Isoforms;Qualifying;Radiation;Radiation Accidents;Radiation Dose Unit;radiation effect;Radiation exposure;Radiation Injuries;radiation mitigation;Radiation Toxicity;Research;response;RNA;Rodent;Role;Salmonella typhimurium;Small Intestines;subcutaneous;Supplementation;Survival Rate;systemic inflammatory response;TCF7L2 gene;Testing;Therapeutic;Time;transcription factor;WNT Signaling Pathway

PROJECT_TITLE: Radiation-Induced Paneth Cell Dysfunction


ADMINISTERING_IC: CA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: OVERALL: PROJECT NARRATIVE The mission of the University of Florida Health Cancer Center (UFHCC) is to prevent, detect, and ultimately cure cancer and address the unique challenges of the cancer burden faced by the population we serve by facilitating innovative, collaborative, transdisciplinary cancer research. UFHCC will achieve these goals through discovery and research innovations in cancer mechanisms, prevention, screening, and treatment, while training the next generation of cancer scientists and leaders and engaging the communities and populations we serve.

PI_NAMEs: LICHT, JONATHAN D. (contact)

PROGRAM_OFFICER_NAME: ROBERSON, SONYA

PROJECT_TERMS: Abbreviations;Achievement;Address;Aging;Agriculture;American Cancer Society;anti-cancer research;Area;Arts;Basic Cancer Research;Biology;Biomedical Research;Biometry;Black race;Breast;Budgets;Cancer Burden;Cancer Center;Cancer Center Support Grant;Cancer Control;Cancer Etiology;cancer health disparity;cancer prevention;Cancer Research Project;cancer therapy;Cancer Vaccines;career;career development;Catchment Area;Cells;Classification;Clinic;Clinical;Clinical Cancer Center;Clinical Investigator;Clinical Research;Clinical Sciences;Clinical Trials Network;clinically relevant;cohort;Collaborations;college;Colorectal;Communication;Communities;community advisory board;community engagement;Community Outreach;Complex;Confocal Microscopy;County;Data Set;Dentistry;Development;Developmental Therapeutics Program;Diagnosis;Discipline of Nursing;Disease;Diverse Workforce;diversity and inclusion;Educational Activities;Engineering;equity, diversity, and inclusion;Faculty;Florida;Flow Cytometry;Fostering;Funding;Genetic Research;Goals;Health;health literacy;Health Occupations;Health Sciences;high school;Hispanic;Human;human old age (65+);Human Papilloma Virus Vaccination;Immune response;Immunotherapy;improved;innovation;Institution;Intervention;Intervention Trial;investigator-initiated trial;Journalism;Laboratories;Last Name;Lead;leadership development;leukemia;Lung;Malignant Neoplasms;marine organism;Medically Underserved Area;Medicine;member;Mentorship;microbiome;Mission;Molecular Carcinogenesis;NCI Center for Cancer Research;NCI-Designated Cancer Center;New England;next generation;next generation sequencing;novel;Oncoproteins;Outcome;Patients;Peer Review;Performance;personalized medicine;Persons;Pharmacy facility;Play;Population;population based;Population Sciences;Preclinical Testing;prevent;Prevention;Prevention strategy;Prevention trial;programs;Public Health;Publications;recruit;Regional Cancer;Research;Research Personnel;Research Project Grants;Resource Sharing;Resources;RNA;Rural;rural counties;Science;Scientific Advances and Accomplishments;Scientist;screening;Screening for cancer;Shapes;Site;small molecule;smoking cessation;Strategic Planning;survivorship;Talents;targeted treatment;Teacher Professional Development;Technology;Testing;Text;Therapeutic;Tobacco use;Training;Training Programs;Translating;Translational Research;Translations;treatment response;tumorigenesis;Underrepresented Minority;Universities;Woman;Workforce Development

PROJECT_TITLE: University of Florida Health Cancer Center Support Grant

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


NIH_SPENDING_CATS: Cancer

PI_NAMEs: HOULIHAN, ROBERT H (contact)

PROJECT_TERMS: Abbreviations;Acceleration;Address;Administrator;Advisory Committees;anti-cancer research;Area;Award;Biometry;Budgets;Businesses;Cancer Burden;Cancer Center;Cancer Center Support Grant;Cancer Control;Caring;Catchment Area;CCL21 gene;Clinical;Clinical Research;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;college;Communication;Communities;community engagement;Community Outreach;community partners;Complex;Confocal Microscopy;data integrity;data warehouse;Dedications;Direct Costs;Disease;electronic data;Electronic Mail;Ensure;Evaluation;experience;Faculty Recruitment;Florida;Flow Cytometry;Fostering;Funding;Future;Goals;Grant;Growth;Health;Immune response;Informatics;Institution;Last Name;Leadership;Link;Malignant Neoplasms;Measures;meetings;member;Mission;Monitor;nature center;NCI Center for Cancer Research;next generation sequencing;novel;Occupational activity of managing finances;Online Systems;Patients;Peer Review;Policies;Population Sciences;Process;Program Development;programs;recruit;Reporting;Research;Research Personnel;Research Priority;Research Project Grants;Research Support;Research Training;Resource Sharing;Resources;Role;Safety;Science;screening;Screening for cancer;Site;skills;Strategic Planning;success;symposium;Text;Training;Training and Education;training opportunity;treatment response;tumorigenesis;Universities;Vision

PROJECT_TITLE: Administration


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Prevention;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PI_NAMEs: GOATE, ALISON M (contact)

PROJECT_TERMS: abeta deposition;Address;Adult;Age;aged;Aging;Alleles;Alzheimer's Disease;Alzheimer's disease risk;Apolipoprotein E;apolipoprotein E-3;apolipoprotein E-4;Apolipoproteins;Astrocytes;Bioinformatics;Biology;Biometry;Brain;Brain Diseases;brain tissue;Cell Physiology;Cholesterol;Cognitive;Collaborations;Communities;Complex;cytokine;Data;data management;Demyelinations;Disease;Disease susceptibility;Dose;EIF2B2 gene;Elderly;Enhancers;Event;Gene Modified;Generations;Genes;Genetic;Genetic study;genome editing;genome wide association study;Genotype;Goals;Hematopoietic stem cells;Homozygote;Human;human induced pluripotent stem cells;In Vitro;in vivo;insight;Isogenic transplantation;lifetime risk;Lipids;loss of function;Macrophage;Mediating;Microglia;Modeling;Molecular;Mus;Myelogenous;neuropathology;new therapeutic target;normal aging;novel;Pharmaceutical Preparations;Phenotype;Population;Population Study;protective allele;Research;Resources;response;Risk;risk variant;Sampling;single-cell RNA sequencing;Tissues;transcriptomics;TREM2 gene;Variant;Work

PROJECT_TITLE: Genetic modifiers of APOE-related risk for AD


ORG_CITY: Lake Wales

ORG_NAME: SUSTAINABLE WORKPLACE ALLIANCE, INC.

PHR: The Sustainable Workplace Alliance and its alliance partners will provide model training to better protect workers, first responders and citizens in underserved communities that have been negatively impacted by pollution, blight and emergency events. These vulnerable populations are unlikely to know their rights to a safe workplace, the inherent risks of the work they do, the dangers of misuse of opioids, the hazards created by pollution or hazardous materials, and the most effective ways to protect themselves from these harms. This model training and outreach program is designed to reduce injuries and death and to place disadvantaged citizens in viable jobs in the environmental and construction industries.

PI_NAMEs: CASAVANT, DAVID  (contact);WEBER, CHRISTIAN H

PROGRAM_OFFICER_NAME: PERSAUD, ERIC

PROJECT_TERMS: Abate;Adult;Advocate;American Samoa;Area;Asbestos;Awareness;Back;behavior change;career;Caribbean region;Cessation of life;coal ash;Communities;community organizations;Community Outreach;Containment;Contractor;Data;design;Disadvantaged;Economics;Ecosystem;Education and Outreach;Educational process of instructing;Emergency response;Emergency Situation;Emotional;Employment;Environment;Event;Excision;Exposure to;Faith-based organization;Family;Fire - disasters;first responder;Florida;Generations;Geography;Goals;Grant;Guam;Hawaii;hazard;Hazardous Substances;Hazardous Waste;Hazardous Waste Operations and Emergency Response;Health;Hispanic;Hospitals;Hour;improved;Industry;Infrastructure;Injury;innovation;Institution;Instruction;lead paint;Longevity;member;Mentors;Methods;Modeling;Molds;National Institute of Environmental Health Sciences;Northern Mariana Islands;Occupations;opioid epidemic;opioid misuse;outreach;outreach program;Pacific Islands;pain reduction;Palau;Paramedical Personnel;Personal Satisfaction;Persons;Police;Pollution;Population;prevent;Professional Organizations;programs;Public Health;Publishing;Puerto Rico;remediation;Research;Rights;Risk;Rural;Safety;Services;Site;Spanish/English;statistics;Student recruitment;student training;Students;Superfund;Testing;Trainers Training;Training;Training Programs;Transportation;underserved community;United States Virgin Islands;volunteer;vulnerable community;Vulnerable Populations;Work;Workforce Development;Workplace

PROJECT_TITLE: Hazardous Materials Worker Health and Safety Training


NIH_SPENDING_CATS: Cancer;Prevention

PI_NAMEs: SIEMANN, DIETMAR W (contact)

PROJECT_TERMS: Abbreviations;academic program;Accreditation;Advisory Committees;American Cancer Society;anti-cancer research;Award;Awareness;Basic Science;Biometry;California;Cancer Biology;cancer care;Cancer Center;Cancer Center Support Grant;Cancer Control;cancer education;Cancer Etiology;cancer health disparity;cancer risk;career;Career Choice;career development;Caring;Clinical;Clinical Cancer Center;Clinical Research;Clinical Sciences;clinical training;Clinical Trials;Collaborations;college;Communities;community engagement;Community Outreach;Community Physician;Continuing Education;continuing medical education;Dedications;design;Development;Disabled Persons;disadvantaged background;Discipline;Disparity population;Doctor of Philosophy;drug discovery;Education;education research;Epidemiology;equity, diversity, and inclusion;Ethnic Population;experience;Faculty;faculty mentor;faculty support;falls;Florida;Fostering;Funding;Goals;Graduate Education;graduate medical education;graduate student;Grant;Grant Review;Health;health equity;Health Professional;Health Sciences;high school;High School Student;Hispanic-serving Institution;Historically Black Colleges and Universities;Immune response;Individual;innovation;Institution;interest;Investigational Therapies;junior high school;Laboratories;laboratory experience;Last Name;Lead;Learning;lectures;Malignant Neoplasms;Manuscripts;Medicine;member;Mentors;Mentorship;minority student;Minority-Serving Institution;multidisciplinary;Nature;next generation;novel;Nursing Faculty;Oncology;Outcome;peer coaching;Population;Population Sciences;Postbaccalaureate;Postdoctoral Fellow;pre-doctoral;Prevention;Productivity;programs;racial population;recruit;Research;Research Personnel;Research Project Grants;Research Training;Resource Sharing;Resources;Risk Factors;Scholars Program;Science;science teacher;Scientist;skills;Strategic Planning;Structure;Students;summer internship;summer program;Teacher Professional Development;TNFSF15 gene;Training;Training and Education;training opportunity;Training Programs;translational cancer research;translational potential;Translational Research;treatment response;tumorigenesis;undergraduate student;Underrepresented Minority;Underrepresented Populations;Universities;Woman;Work;Workforce Development;working group

PROJECT_TITLE: Cancer Research Training and Education Coordination


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Eye Disease and Disorders of Vision;Neurosciences;Prevention

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE We propose to develop technical advances necessary for increasing the field of view of adaptive optics ophthalmoscopes, in order to overcome a barrier for detecting the earliest signs of eye disease. This will in turn enable the early treatment necessary to mitigate irreversible but preventable vision loss in conditions for which treatments currently exist.

PI_NAMEs: DUBRA, ALFREDO  (contact)

PROGRAM_OFFICER_NAME: SHEN, GRACE L

PROJECT_TITLE: Increasing the isoplanatic patch in adaptive optics ophthalmoscopy


NIH_SPENDING_CATS: Health Disparities and Racial or Ethnic Minority Health Research;Opioid Misuse and Addiction;Opioids;Prevention;Racial and Ethnic Minority Health Research;Substance Misuse

PI_NAMEs: CASAVANT, DAVID  (contact)

PROJECT_TERMS: Abate;Adult;Advocate;American Samoa;Area;Asbestos;Awareness;behavior change;Caribbean region;coal ash;Communities;community organizations;Community Outreach;Containment;Contractor;Data;Ecosystem;Education and Outreach;Educational process of instructing;Emergency Situation;Employee;Environment;Event;Excision;experience;Exposure to;Faith-based organization;Florida;Generations;Geography;Goals;Grant;Guam;Harm Reduction;Hawaii;hazard;Hazardous Substances;Hazardous Waste;Hazardous Waste Operations and Emergency Response;Health;Hispanic;Hour;Injury;innovation;Institution;lead paint;Methods;Modeling;Molds;Northern Mariana Islands;Occupations;operation;opioid abuse;opioid misuse;outreach;Pacific Islands;pain reduction;Palau;Pollution;prevent;Professional Organizations;programs;Public Health;Publishing;Puerto Rico;recruit;remediation;Research;restoration;Rights;Risk;Safety;Services;Site;statistics;Students;Superfund;Testing;Trainers Training;Training;Training Programs;Transportation;United States Virgin Islands;vulnerable community;Vulnerable Populations;Work;Workforce Development;Workplace

PROJECT_TITLE: Hazardous Waste Worker Training Program


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lead Poisoning;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PROJECT_TERMS: Abate;Address;Adult;American Samoa;Area;Asbestos;Awareness;career;Career Choice;Certification;Cessation of life;Classification;Communities;community organizations;Contractor;Data;design;Disadvantaged;Disasters;Distress;Economic Burden;Economic Development;Economics;Education and Outreach;Educational process of instructing;Emergency Situation;Emotional;Employment;Employment Opportunities;environmental justice;Event;Excision;Exposure to;Faith-based organization;Family;Federal Government;First Aid;Florida;Future;Geographic Locations;Geography;Goals;Grant;Growth;Guam;Hawaii;hazard;Hazardous Substances;Hazardous Waste;Hazardous Waste Operations and Emergency Response;Hazardous Waste Sites;Health;health disparity;Hour;improved;Industry;Injury;innovation;Institution;Label;lead paint;Life;Local Government;Longevity;low socioeconomic status;Mentors;Methods;Modeling;Molds;neighborhood disadvantage;Occupations;Opioid;opioid misuse;outreach program;Pacific Islands;Palau;people of color;Personal Satisfaction;Persons;Petroleum;Pollution;Population;Preparation;prevent;Privatization;Professional Organizations;programs;Public Health;Publishing;Puerto Rico;Red Cross;remediation;Research;Rights;Risk;Safety;Services;Site;skills;Spanish/English;State Government;statistics;Student recruitment;Students;Superfund;Testing;Training;Training Programs;Underemployment;underserved community;Unemployment;United States Virgin Islands;Vulnerable Populations;Work;Workforce Development;Workplace

PROJECT_TITLE: Environmental Career Worker Training Program


NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Clinical Research;Emergency Care;Health Services;Prevention

PROJECT_TERMS: Adult;Advocate;American Samoa;Ammonia;Area;Awareness;behavior change;career;Caribbean region;Cessation of life;Chlorine;climate change;Committee Members;Communities;community organizations;Community Outreach;Data;Decontamination;design;Disasters;Education and Outreach;Educational process of instructing;Emergency response;Emergency Situation;Environment;Event;Exposure to;Faith-based organization;Fire - disasters;fire fighter;First Aid;first responder;Florida;Fostering;Geography;Goals;Grant;Guam;Hawaii;hazardous materials disaster;Hazardous Substances;Health;Healthcare;Hospitals;Hour;Human Resources;Injury;innovation;Location;member;Methods;Modeling;Needs Assessment;Northern Mariana Islands;Occupational Exposure;Occupations;Oils;operation;Opioid;outreach;outreach program;Pacific Islands;Palau;Paramedical Personnel;pathogen;Police;Population;Preparation;prevent;programs;Public Health;Publishing;Puerto Rico;Readiness;recruit;Research;resilience;response;Safety;Services;severe weather;Site;statistics;synthetic opioid;Testing;Training;Training Programs;United States Virgin Islands;volunteer;Vulnerable Populations;Work;Workplace

PROJECT_TITLE: Hazmat Disaster Preparedness Training Program


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

PI_NAMEs: RICKS-SANTI, LUISEL J. (contact)

PROJECT_TERMS: Abbreviations;Address;Affinity;anti-cancer research;Biometry;Black race;California;Cancer Center;Cancer Center Support Grant;Cancer Control;Caring;Catchment Area;Charge;Clinical Sciences;cohort;college;Communities;community engagement;Community Outreach;cultural competence;Development;Disabled Persons;disadvantaged background;Disease;Disparity population;Education;education research;Ensure;equity, diversity, and inclusion;Ethnic Population;Evaluation;Faculty;Faculty Recruitment;Female;Florida;Foundations;Future;Geography;Goals;graduate student;Grant;Health;health equity;Health Occupations;Hispanic;Historically Black Colleges and Universities;Hospitals;Immune response;improved;Individual;Infrastructure;Institution;Laboratories;Last Name;Leadership;Malignant Neoplasms;Medical Students;Medicine;member;Mentors;Mentorship;Minority;Monitor;NCI Center for Cancer Research;next generation;Policies;Population;Population Programs;Population Sciences;Positioning Attribute;Postbaccalaureate;Process;Program Development;programs;Race;racial population;recruit;Research;Research Personnel;Research Training;Resource Sharing;Resources;Schools;Science;Site;skills;socioeconomic disparity;Strategic Planning;Structure;Students;success;Talents;Teacher Professional Development;tenure track;Training;Training and Education;training opportunity;Training Programs;Translational Research;treatment response;tumorigenesis;undergraduate student;Underrepresented Minority;Underrepresented Populations;United States National Institutes of Health;Universities;Woman

PROJECT_TITLE: Plan to Enhance Diversity


NIH_SPENDING_CATS: Diabetes;Estrogen;Kidney Disease;Women's Health Research

ORG_CITY: TAMPA

ORG_NAME: UNIVERSITY OF SOUTH FLORIDA

PHR: Project Narrative Diabetes and its renal complications are becoming epidemic in the U.S. population. The central hypothesis of this proposal is that the cGAS–STING pathway contributes to the progression of diabetic kidney disease (DKD) and sexual dimorphism observed in type 2 diabetic nephropathy (T2DN) rats. This proposal will explore sex differences in T2DN rats and the role of the cGAS-STING pathway in kidney injury, potentially uncovering a new therapeutic target for DKD.

PI_NAMEs: STARUSCHENKO, ALEXANDER  (contact)

PROGRAM_OFFICER_NAME: MARIC-BILKAN, CHRISTINE

PROJECT_TERMS: Address;Chronic;Chronic Kidney Failure;Clinical;Complications of Diabetes Mellitus;Cyclic GMP;Data;defined contribution;design;Development;Diabetes Mellitus;diabetic;Diabetic Nephropathy;Disease;disease phenotype;Disease Progression;drug development;Drug Targeting;Epidemic;Female;Fibrosis;Goals;Gonadal Steroid Hormones;Human;hypertensive;in vivo;Inflammation;Inflammatory;inhibitor;Injury;Injury to Kidney;interest;Kidney;Knowledge;Link;male;Malignant Neoplasms;men;Mitochondria;Modeling;Molecular;new therapeutic target;Non obese;Pathway interactions;Pharmaceutical Preparations;Pharmacologic Substance;Physiological;Pilot Projects;Plasma;Play;Population;Publishing;Rattus;Renin-Angiotensin-Aldosterone System;Reporting;Research;Role;sex;Sex Differences;sexual dimorphism;sexual role;Signal Pathway;Signaling Protein;Stimulator of Interferon Genes;Study models;Therapeutic;translational potential;Tubular formation;Type 2 diabetic;Woman

PROJECT_TITLE: Sexual dimorphisms and role of the cGAS-STING pathway in diabetic nephropathy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-KUDS-W(05)]


ORG_CITY: PROVIDENCE

ORG_NAME: OCEAN STATE RESEARCH INSTITUTE, INC.

ORG_STATE: RI

PHR: The vision of the CardioPulmonary Vascular Biology (CPVB) COBRE program is to develop effective approaches to prevent and treat vascular diseases affecting the pulmonary and cardiovascular systems through better understanding of disease mechanisms. This will be accomplished by serving as an interdisciplinary center which promotes collaborative research and provides excellent technical support and resources to investigators. The overall mission of the CPVB COBRE program has been to build the human and technical infrastructure and services that serve as catalysts to increase research in cardiopulmonary vascular biology in the state.

PI_NAMEs: CHOUDHARY, GAURAV  (contact)

PROGRAM_OFFICER_NAME: MATUKUMALLI, LAKSHMI KUMAR

PROJECT_TERMS: 2019-nCoV;Advisory Committees;Affect;Area;Award;Biology;Blood Vessels;Cardiopulmonary;Cardiovascular Diseases;Cardiovascular system;career;catalyst;Cause of Death;Cell Separation;Centers of Research Excellence;Collaborations;combat;Communities;comorbidity;Coronary Arteriosclerosis;COVID-19 pandemic;Data;Development;Discipline;Disease;Educational workshop;effective therapy;Feedback;Fostering;Funding;Goals;Growth;Home;Human;in vivo imaging;Infection;Infrastructure;Institution;Investigation;Learning;Legal patent;Lung;Lung Diseases;Manuscripts;Mission;Mitochondria;Morbidity - disease rate;mortality;Organ;Pathogenesis;Phase;Pilot Projects;prevent;Prevention;Productivity;Prognosis;programs;Publishing;pulmonary vascular disorder;Research;Research Personnel;Research Project Grants;Resources;respiratory;Respiratory Disease;Rhode Island;Scientist;Services;Structure;Vascular Diseases;Virus;Vision

PROJECT_TITLE: CardioPulmonary Vascular Biology COBRE


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding

PROJECT_TERMS: Advisory Committees;Affect;Area;Award;Benchmarking;Biology;Biomedical Research;Blood Vessels;Cardiopulmonary;Cardiovascular system;career;career development;Centers of Research Excellence;Collaborations;combat;Communication;Communities;Data Collection;Development;Disease;Educational workshop;Equipment;Evaluation;Evolution;Extramural Activities;Faculty;Feedback;Fostering;Funding;Goals;Grant;Home;improved;Institution;Leadership;Lung;Maintenance;Manuscripts;Measures;medical schools;meetings;Occupational activity of managing finances;Oceans;Office of Administrative Management;Phase;Pilot Projects;prevent;professor;Program Development;programs;Progress Reports;Publishing;Research;Research Institute;Research Personnel;Research Project Grants;Resources;Rhode Island;satisfaction;Series;Services;Supervision;symposium;Training;Universities;Vascular Diseases;Vision;Visit;web site

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Lung Cancer;Obesity;Prevention;Rural Health;Social Determinants of Health;Tobacco;Tobacco Smoke and Health

PI_NAMEs: BRAITHWAITE, DEJANA K (contact)

PROJECT_TERMS: Abbreviations;Achievement;Address;Advocate;Age;Aging;Agriculture;anti-cancer research;Area;Arts;Behavioral;Biological Sciences;Biomedical Research;Biometry;Black race;Breast;Breast Cancer Detection;Cancer Biology;Cancer Burden;Cancer Center;Cancer Center Support Grant;Cancer Control;Cancer Etiology;cancer health disparity;cancer imaging;cancer prevention;Cancer Prevention Intervention;cancer risk;Cancer Survivor;cancer therapy;Catchment Area;clinical practice;Clinical Sciences;clinical trial enrollment;Collaborations;college;Colorectal;colorectal cancer screening;Communication;Communities;community collaboration;community engaged research;community engagement;Community Outreach;community partnership;Confocal Microscopy;Death Rate;Dentistry;Development;Diagnostic;Diet;digital;digital health;Discipline of Nursing;Disparity;Dissemination and Implementation;Early Diagnosis;effectiveness trial;efficacy trial;Electronic Health Record;energy balance;Engineering;Enrollment;Equilibrium;ethnic minority;Etiology;Extramural Activities;Florida;Flow Cytometry;Funding;Future;Goals;graduate student;Grant;Guidelines;Health;Health Occupations;Hepatitis C Therapy;high risk;Hispanic;HPV vaccine acceptance;Human;human old age (65+);Human Papilloma Virus Vaccination;Human Papilloma Virus-Related Malignant Neoplasm;imaging biomarker;Immune response;implementation science;Incidence;Informatics;innovation;Institution;Interdisciplinary Study;Intervention;Intervention Studies;Intervention Trial;Journalism;Last Name;Late Effects;Lung;Malignant neoplasm of liver;Malignant neoplasm of prostate;Malignant Neoplasms;medically underserved population;Medicine;member;Mentors;modifiable risk;Molecular;molecular marker;mortality;next generation sequencing;Not Hispanic or Latino;novel;Obesity;Observational Study;older adult;older men;older women;Outcome;Participant;patient engagement;Patient Outcomes Assessments;Peer Review;Performance;personalized intervention;Pharmacy facility;Physical activity;Policies;Population;Population Heterogeneity;Population Sciences;Postdoctoral Fellow;Pragmatic clinical trial;pragmatic trial;prevent;Prevention program;Prevention strategy;Primary Cancer Prevention;programs;proton therapy;Public Health;Publications;Publishing;racial minority;Radiation;Radiation Dose Unit;recruit;Research;Research Activity;Research Design;Research Personnel;Resource Sharing;Risk Factors;Rural;rural counties;Rural Population;Sales;scale up;Science;screening;Screening for cancer;Secondary Cancer Prevention;Smoking;social;social determinants;Strategic Planning;Survivors;survivorship;Symptom Burden;Testing;Therapeutic;Tobacco;Tobacco Control Research;Tobacco use;tool;Training;Training and Education;Translating;translational pipeline;Translational Research;treatment response;trial design;tumorigenesis;Underrepresented Minority;Underserved Population;Universities;Woman

PROJECT_TITLE: Cancer Control and Population Sciences Research Program


NIH_SPENDING_CATS: Pediatric;Women's Health Research

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE We propose an innovative training program in basic and translational Women's Reproductive Health Research for Obstetrics and Gynecology-trained MD and MD/PhD-physician scientists in an exceptional research environment. The program's mission is to offer rigorous basic and translational laboratory research training coupled to structured career mentoring to junior faculty members of the Baylor College of Medicine Department of Obstetrics and Gynecology. The ultimate goal is to prepare the future academic research leaders in Obstetrics and Gynecology who are prepared to ask and comprehensively address the most important research questions that when answered can ultimately improve women's health.

PI_NAMEs: BELFORT, MICHAEL A (contact)

PROGRAM_OFFICER_NAME: KAUFMAN, STEVEN

PROJECT_TERMS: Advisory Committees;Area;Benchmarking;career;career development;Chairperson;Child;Clinical Research;college;course development;Data Analyses;Dedications;Discipline of obstetrics;diversity and inclusion;Doctor of Philosophy;education planning;Evaluation;experience;faculty mentor;faculty research;Fellowship Program;Funding;Future;Goals;Gynecology;Individual;innovation;laboratory development;Leadership;Medicine;meetings;Mentors;Mission;Needs Assessment;next generation;Peer Review;Physicians;Positioning Attribute;Professional Organizations;programs;Publications;Qualifying;recruit;reproductive;Research;research and development;Research Personnel;Residencies;Resources;Schedule;Scientist;Texas;Training;Translational Research;translational scientist;United States National Institutes of Health;Women's Health

PROJECT_TITLE: Baylor College of Medicine and Texas Children's WRHR Center of Excellence


NIH_SPENDING_CATS: Atherosclerosis;Building Research Capacity at Institutions with Limited NIH Funding;Cardiovascular;Heart Disease;Lung;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Pulmonary Fibrosis;Rare Diseases

PI_NAMEs: HARRINGTON, ELIZABETH O (contact)

PROJECT_TERMS: Acute Respiratory Distress Syndrome;Arterial Fatty Streak;Asthma;Atherosclerosis;Biology;Blood Vessels;Bronchopulmonary Dysplasia;Cardiac;Cardiac Myocytes;Cardiopulmonary;Cell Physiology;Cell Separation;Cells;Centers of Research Excellence;Collaborations;Communities;Congenital Heart Defects;Consumption;Coronary;Coronary Arteriosclerosis;cost;COVID-19/ARDS;data acquisition;Data Analyses;Development;Disease;Endothelial Cells;Endothelium;Experimental Designs;Fibroblasts;Fostering;Functional disorder;Generations;Goals;Heart;Heart Diseases;Hypoxemia;idiopathic pulmonary fibrosis;Individual;Inflammation;Injury;injury and repair;insight;instrument;Interruption;Ischemia;Lung;Lung Diseases;lung vascular injury;Measurement;Mutation;Myocardial Reperfusion Injury;Natural regeneration;Obstruction;Organ;pandemic disease;Pathogenesis;Perfusion;Phase;Pilot Projects;Prevention;Productivity;programs;Pulmonary Hypertension;quality assurance;repaired;Reperfusion Injury;Reproducibility;Research;Research Personnel;response to injury;restoration;Rhode Island;Services;skills;Standardization;Systemic hypertension;Technical Expertise;Techniques;Technology;temporal measurement;Thrombosis;Tissues;tool;Training;transcription factor;Translating;Vascular Diseases;vascular injury;Vascular remodeling;Vascular resistance;Vascularization;Vasomotor;ventilation;vessel regression;Work

PROJECT_TITLE: Cell Isolation and Organ Function Core


PI_NAMEs: JOBIN, CHRISTIAN  (contact)

PROJECT_TERMS: Acceleration;Address;Advanced Malignant Neoplasm;Affect;Antineoplastic Agents;authority;Award;Bacteria;base;Basic Science;BCL2L1 gene;biobank;Biomedical Engineering;biomedical referral center;Blood;Brain;Cancer Biology;Cancer Center;Cancer Center Support Grant;cancer immunobiology;Cancer Patient;cancer therapy;carcinogenesis;Cell Physiology;Cells;chimeric antigen receptor T cells;citizen science;Clinic;Clinical;clinical candidate;clinical development;Clinical Investigator;Clinical Research;clinical trial protocol;Clinical Trials;Clinical Trials Design;Collaborations;college;Colorectal;Combined Modality Therapy;Complex;Cyclic GMP;cytotoxic;design;Development;Direct Costs;Disease;Drug Interactions;drug metabolism;early phase clinical trial;Enrollment;Epithelium;equity, diversity, and inclusion;first-in-human;Florida;Foundations;frontier;Funding;Future;graduate student;Grant;Health;Hematopoietic stem cells;Histone Deacetylase;human study;Immune;Immune Evasion;Immune response;Immune system;Immunobiology;Immunology;Immunooncology;Immunosuppression;Immunotherapeutic agent;Immunotherapy;individualized medicine;Infection;Inflammation;Infrastructure;inhibitor;innovation;Institution;Intervention;Intervention Trial;Investments;Laboratory Scientists;Leadership;Legal patent;leukemia;Life;Lung;Malignant neoplasm of brain;Malignant neoplasm of lung;Malignant Neoplasms;Mediating;Medicine;meetings;member;Mentors;Messenger RNA;metabolomics;Microbe;microbial;microbiome;microorganism;Modality;Modeling;Mutagens;nanoparticle;Natural Products;neoplastic cell;new combination therapies;new therapeutic target;Non-Small-Cell Lung Carcinoma;novel;novel therapeutics;Pathway interactions;patient oriented;patient population;Patients;Peer Review;Pharmaceutical Chemistry;Phase I Clinical Trials;Population;Postdoctoral Fellow;pre-clinical;Preparation;Process;Production;programs;Property;protocol development;Publications;Publishing;rational design;recruit;Refractory;Research;research clinical testing;Research Personnel;Resources;response;RNA;RNA vaccine;Scientist;screening;Sea;senolytics;small molecule;STAT3 gene;Strategic Planning;Structure;targeted treatment;Therapeutic;Therapeutic Research;Time;Training;Translating;translational immunology;Translations;treatment response;treatment trial;trial design;tumor;Tumor Immunity;tumor progression;Underrepresented Minority;United States National Institutes of Health;Universities;vaccine trial;Vaccines;Woman;Work;working group

PROJECT_TITLE: Cancer Therapeutics and Host Response Research Program


NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Neurosciences;Post-Traumatic Stress Disorder (PTSD);Serious Mental Illness;Suicide

ORG_CITY: NEW HAVEN

ORG_DEPT: PSYCHIATRY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative Borderline Personality Disorder (BPD) is a common psychiatric condition that increases risk for poor social and work functioning and for suicide. The core problems underlying BPD are not known; understanding the mechanism of this illness is critical to improving outcomes. The proposed studies will use neuroimaging methods and novel computational modelling approaches to define the brain basis of BPD pathophysiology and to lay groundwork for developing new therapeutics.

PI_NAMEs: FINEBERG, SARAH K (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: Acute;adverse childhood events;Affect;Amygdaloid structure;Anterior;Behavior;Behavioral;behavioral response;Biological Response Modifier Therapy;Borderline Personality Disorder;Brain;career;career development;caregiving;cingulate cortex;Classification;Clinical;clinical predictors;Clinical Research;Clinical Treatment;comorbidity;comparison group;completed suicide;Computer Models;Control Groups;Cues;Data;Data Analyses;Data Collection;defined contribution;design;Diagnostic Specificity;Disease;Distress;distrust;effective therapy;Environment;expectation;experience;Family;FDA approved;Foundations;Functional disorder;Functional Magnetic Resonance Imaging;Future;Goals;Hyperactivity;Impairment;improved;improved outcome;Impulsivity;Individual;Individual Differences;Intervention;Learning;Measures;Medical;Mental disorders;Mentors;Mentorship;Methodology;Methods;Modeling;Moods;neglect;neural;neurobiological mechanism;Neurobiology;neurofeedback;neuroimaging;neuromechanism;neurotransmission;novel;novel therapeutic intervention;novel therapeutics;Participant;patient oriented;Patient Self-Report;Patients;Pattern;Perception;Performance;Persons;Pharmaceutical Preparations;Phenotype;Physicians;Population;Post-Traumatic Stress Disorders;Prevalence;Probability;Prognosis;Psyche structure;Psychiatry;Psychotherapy;Recovery of Function;Research;Research Design;Resources;response;Rest;Reversal Learning;Rewards;Risk;Risk Factors;Role;Scientist;Signal Transduction;skills;social;social deficits;Social Functioning;social learning;Social Problems;Specificity;suicidal risk;Suicide;Suicide attempt;Supervision;Symptoms;Testing;theories;Time;Training;Trauma;trauma exposure;Trust;trustworthiness;Volatilization;Work

PROJECT_TITLE: Modeling learning under volatility in Borderline Personality Disorder

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Genetics;Macular Degeneration;Neurodegenerative;Neurosciences

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE: Age-related macular degeneration (AMD), the most common cause of blindness among the elderly, is initiated by retinal pigmented epithelial (RPE) degeneration due to lysosomal dysfunction. Dysfunction of lysosomes can affect the normal functioning of the cellular clearance process to cause disease. This proposal will determine the extent that transcription factor EB (TFEB) activation by gene therapy can restore lysosomal function, RPE degeneration, and an AMD-like phenotype using an AMD-like mouse model and in human-iPSC derived RPE cells from AMD donors.

PI_NAMEs: HANDA, JAMES T;SINHA, DEBASISH  (contact)

PROGRAM_OFFICER_NAME: NEUHOLD, LISA

PROJECT_TERMS: Actins;activating transcription factor;Address;adeno-associated viral vector;Affect;Age;Age related macular degeneration;age-related disease;Aging;aging population;Antioxidants;Autoantibodies;Automobile Driving;Autophagocytosis;Autophagosome;bafilomycin A1;Behavior;bevacizumab;Biogenesis;Blindness;Cell Death;Cell Nucleus;Cell Physiology;Cells;Cessation of life;Characteristics;Chronic;cigarette smoke;conditional knockout;Crystallins;Cytoskeletal Modeling;Cytosol;Defect;Disease;Dose;E-Cadherin;Elderly;Endosomes;Environment;Epidermal Growth Factor Receptor;epithelial to mesenchymal transition;Epithelium;Exhibits;Eye;Functional disorder;Gene Activation;gene network;gene therapy;Genetically Engineered Mouse;Health;Heterogeneity;Homeostasis;Human;human induced pluripotent stem cells;Impairment;in vivo;induced pluripotent stem cell;Injections;Knockout Mice;Laboratories;Link;Lysosomes;Mesenchymal;Messenger RNA;Micronutrients;Minority;Molecular Analysis;mouse model;mutant;neovascular;Nonexudative age-related macular degeneration;novel;novel therapeutics;Nuclear;Oxidative Stress;Pathogenesis;Pathologic;Pathology;Patients;Phagocytosis;Phenotype;pre-clinical;preservation;prevent;Prevention;Process;promoter;Proteins;Receptor Signaling;Rejuvenation;Resistance;response;Retina;Rodent Model;Stains;Stress;Structure of retinal pigment epithelium;targeted treatment;Testing;Therapeutic Agents;therapeutic target;Time;Tissues;transcription factor;transcriptome;Vascular Diseases;Vimentin;Vision;Work

PROJECT_TITLE: Targeting lysosome/RPE heterogeneity in AMD pathobiology as a novel therapy


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Hematology;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative Dysregulation of blood stem cells leads to failure of blood cell production. We identified a new pathway, endoplasmic reticulum associated degradation (ERAD), as a critical regulator to maintain blood stem cell functions. The proposed studies will identify the mechanism by which ERAD promotes blood stem cell functions, and provide new insights into how blood stem cell functions are maintained, which potentially can inform novel approach for blood cell regeneration.

PI_NAMEs: LI, QING  (contact)

PROGRAM_OFFICER_NAME: BAI, C BRIAN

PROJECT_TERMS: Area;ATF6 gene;Binding;Blood;Blood Cells;blood treatment;cell regeneration;Cells;Complex;conditional knockout;Cytosol;Data;Defect;Dependence;Dislocations;Endoplasmic Reticulum;endoplasmic reticulum stress;Ensure;Equilibrium;exhaustion;Failure;FRAP1 gene;Genes;Hematological Disease;Hematopoietic;hematopoietic differentiation;hematopoietic stem cell differentiation;hematopoietic stem cell fate;hematopoietic stem cell quiescence;hematopoietic stem cell self-renewal;Hematopoietic stem cells;hematopoietic tissue;insight;Knock-out;Knockout Mice;Malignant Neoplasms;Mediating;Metabolic;misfolded protein;mTOR inhibition;mTOR Signaling Pathway;novel;novel strategies;Output;Pathway interactions;PIK3CG gene;Play;preservation;Production;Proliferating;Protein Biosynthesis;Proteins;proteostasis;PTEN gene;Quality Control;reconstitution;Regulation;Reporting;Research;response;Role;self-renewal;Signal Pathway;Signal Transduction;Sirolimus;stem cell exhaustion;stem cell function;stem cell proliferation;Stress;System;Transplant Recipients;ubiquitin-protein ligase;Ubiquitination;XBP1 gene

PROJECT_TITLE: The role of ER associated degradation (ERAD) in hematopoietic stem cells

STUDY_SECTION: MCH

STUDY_SECTION_NAME: Molecular and Cellular Hematology Study Section[MCH]


ORG_CITY: RICHMOND

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: OVERALL: PROJECT NARRATIVE The mission of the Massey Cancer Center (MCC) is to reduce the state cancer burden for all Virginians by addressing the confluence between biological, social, and policy drivers through high-impact, cutting-edge research; person-centered care across the continuum, from prevention through survivorship; community integration; and training the next generation of community-centric researchers and healthcare professionals. The core of this mission has been supported by the National Cancer Institute’s Cancer Center Support Grant (CCSG) since 1975, and the MCC is seeking renewal of this award for another five years. The CCSG supports efforts across the MCC senior and programmatic leadership; administration; community outreach and engagement; cancer research training and education coordination; promotion of center-wide diversity, equity, and inclusion; shared resource support and management; clinical research infrastructure; and developmental funding to supporting team-based, transdisciplinary research strategies focused on well-defined, catchment area priorities.

PI_NAMEs: WINN, ROBERT A. (contact)

PROGRAM_OFFICER_NAME: BELIN, PRECILLA L

PROJECT_TERMS: Academia;Academic Medical Centers;Address;African American;Algorithms;anti-cancer research;Appointment;Area;authority;Award;Basic Science;Behavioral;Biological;Biometry;Black race;Cancer Biology;Cancer Burden;Cancer Center;Cancer Center Support Grant;Cancer Control;cancer health disparity;Cancer health equity;cancer prevention;Cancer Research Project;Cancer Survivorship;cancer therapy;career development;Caring;Catchment Area;Charge;Cities;Clinical;clinical implementation;Clinical Research;Clinical Sciences;Clinical Trials;cohort;Collaborations;college;Communities;Community Clinical Oncology Program;community engagement;Community Integration;Community Outreach;County;Crime;data acquisition;Data Analyses;Death Rate;Development;Developmental Therapeutics Program;Disparity;driving behavior;Education;Education and Outreach;electronic medical record system;Ensure;equity, diversity, and inclusion;ethnic minority;Ethnic Origin;Excess Mortality;Faculty;Flow Cytometry;Fostering;Funding;Geography;Goals;Growth;Health;health disparity;Health equity research;Health Policy;Health Professional;Health Promotion;Health system;Home;Hot Spot;Housing;improved;Incidence;Individual;innovation;Institution;Intervention;Intervention Trial;Investments;Knockout Mice;Leadership;lipidomics;Malignant Breast Neoplasm;Malignant neoplasm of gastrointestinal tract;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant Neoplasms;Massey Cancer Center at the Virginia Commonwealth University;medically underserved;member;Mentors;metabolomics;Methodology;Microscopy;Mid-Atlantic Region;Minority;Mission;Modeling;multidisciplinary;National Cancer Institute;neighborhood disadvantage;next generation;Obesity;Outcome;Patient Care;Peer Review;person centered;Policies;Population Sciences;Positioning Attribute;Poverty;Prevention;Prevention approach;Primary Care;Production;Productivity;programs;Publications;Race;racial minority;recruit;Reporting;Research;research and development;Research Design;Research Infrastructure;Research Institute;Research Personnel;Resource Sharing;Resources;Rural;rural area;Schools;Science;Scientist;Screening for cancer;Services;Smoking;smoking-related cancer;social;social health determinants;socioeconomic diversity;socioeconomics;Specialist;Speed;Strategic Planning;Students;success;survivorship;Technology;Tissues;Tobacco;Training;Training and Education;Transgenic Organisms;Translations;Underrepresented Minority;underserved area;United States Health Resources and Services Administration;Universities;Virginia;Vision

PROJECT_TITLE: Massey Cancer Center - Cancer Center Support Grant


ADMINISTERING_IC: NR

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cardiovascular;Clinical Research;Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hematology;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Pregnancy;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_DEPT: PEDIATRICS

PHR: Project Narrative This Renewal proposal will use intersectionality and life-course frameworks to assess how risks and disparities in maternal morbidity 1) accrue across multiple forms of marginalization and 2) accrue across multiple pregnancies over time. We will use causal inference and community engagement approaches to 3) translate our results to potential actionable next steps to improve maternal health and eliminate disparities. We will examine severe maternal morbidity, its precursors (hypertensive disorders of pregnancy, anemia, cesarean birth), and its subtypes (hemorrhage-, infection- and hypertension-related severe maternal morbidity).

PI_NAMEs: CARMICHAEL, SUZAN L (contact)

PROGRAM_OFFICER_NAME: SEAY, JULIA SUSAN

PROJECT_TERMS: Address;Affect;Anemia;Birth;Black American;Body mass index;California;Censuses;Cesarean section;Child;Communities;community advisory board;community engaged approach;community engagement;community organizations;Country;Data;data resource;Death Certificates;Disparity;disparity elimination;Education;Ensure;Equity;ethnic disparity;Ethnic Origin;Exclusion;Fetal Death;Health;health disparity;Healthcare;Hemorrhage;high risk;Hospitals;Hypertension;improved;Income;Individual;Inequality;Inequity;Infection;intersectionality;Intervention;Investigation;Joints;Knowledge;large scale data;Life Cycle Stages;Link;Live Birth;longitudinal dataset;marginalization;Masks;Maternal Health;maternal morbidity;Maternal Mortality;maternal outcome;maternal weight;Mediation;Medical;Methods;Morbidity - disease rate;Mothers;Multiple Pregnancy;Native American population;neighborhood disadvantage;Neighborhoods;New Jersey;next generation;Organ failure;Outcome;Outcome Study;parent grant;people of color;Persons;Phase;Population;Population Research;Postpartum Period;Poverty;Pregnancy;pregnancy disorder;pregnancy health;pregnant;prepregnancy;Prevention strategy;Proxy;Race;racial disparity;Records;Recurrence;reproductive;Research;Resources;Risk;Risk Assessment;Risk Factors;Risk Reduction;segregation;Sepsis;severe maternal morbidity;social;social disparities;Social Environment;Social Identification;social structure;socioeconomics;success;Survivors;Time;Translating;Translations;Virginia;Woman;Work

PROJECT_TITLE: Severe Maternal Morbidity: An Investigation of Racial-Ethnic Disparities, Social Disadvantage & Maternal Weight

STUDY_SECTION: SSPA

STUDY_SECTION_NAME: Social Sciences and Population Studies A Study Section[SSPA]


NIH_SPENDING_CATS: Biomedical Imaging;Building Research Capacity at Institutions with Limited NIH Funding;Cardiovascular;Heart Disease;Lung

PI_NAMEs: ZHANG, PENG  (contact)

PROJECT_TERMS: Acute Respiratory Distress Syndrome;Animal Model;Animals;Atherosclerosis;Biological Process;Biology;Biomedical Research;Blood Vessels;Bronchopulmonary Dysplasia;Cardiopulmonary;Centers of Research Excellence;Collaborations;Communities;Coronary Arteriosclerosis;Data;Development;Disease Progression;Echocardiography;Energy Metabolism;Equipment;Fostering;Goals;heart function;Heart Injuries;imager;Imaging technology;in vivo imaging;Incidence;injury and repair;innovation;instrument;inter-institutional;interest;Interruption;Intervention;Lasers;lung injury;microCT;Mission;Mitochondria;mitochondrial dysfunction;Modernization;Morbidity - disease rate;mortality;Myocardial Infarction;Pathogenesis;Phase;Pilot Projects;Play;Positron-Emission Tomography;pre-clinical;preclinical study;Prevention;Procedures;Process;Productivity;programs;Pulmonary Fibrosis;pulmonary function;Pulmonary Heart Disease;Pulmonary Hypertension;repaired;Reproducibility;Research;Research Personnel;Resolution;respiratory;Rhode Island;Role;Scientist;Services;System;Systemic hypertension;Technology;Time Study;tool;Translational Research;United States;vascular injury

PROJECT_TITLE: Mitochondrial Function and In Vivo Imaging Core


NIH_SPENDING_CATS: Biotechnology;Cancer;Emerging Infectious Diseases;Genetics;Infectious Diseases;Lung;Lung Cancer

PI_NAMEs: WU, LIZI  (contact)

PROJECT_TERMS: Abbreviations;Address;Affect;Apoptotic;Area;Award;base;Basic Science;BCL2L1 gene;Biology;biomarker development;Biomedical Research;Biometry;Cancer Biology;Cancer Burden;Cancer Center;Cancer Center Support Grant;Cancer Control;Catchment Area;Chromatin;citizen science;Clinic;Clinical;clinical candidate;clinical development;Clinical Research;clinical translation;Collaborations;college;Colorectal Cancer;Communities;community advisory board;community engagement;Community Outreach;Confocal Microscopy;Cytarabine;Development;Direct Costs;Disease;DNA Tumor Viruses;DNMT3a;Dose;Educational Curriculum;Enzymes;Epigenetic Process;equity, diversity, and inclusion;Event;Faculty;Florida;Flow Cytometry;Focus Groups;Fostering;Funding;Future;Genetic;Goals;graduate student;Grant;Head and neck structure;Health;Hematologic Neoplasms;Human;human DNA;Human Herpesvirus 4;Human Herpesvirus 8;Immune response;Immunity;In Vitro;in vivo Model;Infrastructure;innovation;Institution;investigator-initiated trial;Joints;Last Name;Leadership;Learning;Legal patent;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant Neoplasms;meetings;Melanoma;member;Mentors;Messenger RNA;Methodology;Methods;microbiota;MicroRNAs;Mission;Modeling;Molecular Target;Monitor;multidisciplinary;Mus;mutant;Mutation;Neck Cancer;Neoplastic Cell Transformation;next generation sequencing;novel;novel therapeutic intervention;Oncogenes;oncohistone;Pathway interactions;Peer Review;Peer Review Grants;Phenotype;Population Sciences;Postdoctoral Fellow;precision medicine;Predisposition;Productivity;programs;Proteins;Publications;recruit;Research;Research Personnel;Resource Sharing;RNA;Role;Science;Signal Transduction;Site;Solid;Source;STK11 gene;Strategic Planning;success;therapeutic development;therapeutic RNA;therapeutic target;tobacco prevention;Training;Translating;Translations;treatment response;treatment trial;tumor;tumor initiation;tumor progression;Tumor Suppressor Genes;tumorigenesis;Underrepresented Minority;United States National Institutes of Health;Universities;Untranslated RNA;Viral;virology;Woman;Work;working group

PROJECT_TITLE: Mechanisms of Oncogenesis Research Program