NIH_SPENDING_CATS: Genetics;Neurosciences

ORG_DEPT: BIOLOGY

ORG_NAME: GEORGIA INSTITUTE OF TECHNOLOGY

PHR: PROJECT NARRATIVE Human development depends greatly on the shaping and movements of individual cells. Congenital syndromes, cancer, and other cell diseases occur when there is a breakdown in the regulation of the behaviors of specific cells. We will use the small, transparent embryos of Ciona, one of the invertebrates most closely related to humans, to better understand which genes are activated to regulate such behaviors during neural development, and how cell behavior goes awry when these genes are missing or defective.

PI_NAMEs: COTA, CHRISTINA DONATA;STOLFI, ALBERTO  (contact)

PROGRAM_OFFICER_NAME: STEIN, KATHRYN K

PROJECT_TERMS: Anatomy;Anterior;Automobile Driving;Axon;Behavior;Biochemical Pathway;Biological Availability;cell behavior;Cell Differentiation process;Cell Lineage;cell motility;Cell Physiology;Cell Polarity;Cell Reprogramming;Cells;Central Nervous System;cholinergic;Chordata;connectome;CRISPR/Cas technology;Cues;Development;Disease;Distal;Dorsal;Ectoderm;Embryo;Endosomes;Ensure;Epithelium;extracellular;Fluorescence Microscopy;Gene Expression;Gene Expression Regulation;Genes;genetic architecture;Genetic Transcription;genome editing;Genomics;Homologous Gene;Human;Human Development;in vivo;in vivo imaging;Individual;innovation;insight;Invertebrates;knockout gene;Knowledge;Link;Malignant Neoplasms;Maps;Membrane;migration;Molecular;Morphogenesis;Morphology;Movement;nerve stem cell;Nervous System;Neural Crest;Neural tube;Neurites;neurodevelopment;Neuronal Differentiation;Neurons;notochord;Organism;Outcome;Paraxial Mesoderm;Pathway interactions;Peripheral;polarized cell;Positioning Attribute;Process;programs;Property;Proteins;rab GTP-Binding Proteins;receptor;Recycling;Regulation;Reproducibility;Research;Resolution;response;Role;Sensory;Shapes;Side;Specific qualifier value;Spinal Ganglia;Stereotyping;Study models;Synapses;Syndrome;System;Tail;temporal measurement;Testing;therapy development;Tight Junctions;Tissues;trafficking;transcription factor;Transcriptional Regulation;transcriptomic profiling;Transforming Growth Factor beta;Urochordata;Vertebrates;Work

PROJECT_TITLE: Regulation of neurodevelopmental cell behaviors in Ciona

STUDY_SECTION_NAME: Development - 2 Study Section[DEV2]


ADMINISTERING_IC: AG

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_CITY: NEW YORK

ORG_COUNTRY: UNITED STATES

ORG_DEPT: NEUROLOGY

ORG_FIPS: US

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: OVERALL PROGRAM NARRATIVE The apolipoprotein E4 allele is the major genetic risk factor for late-onset AD; however, currently there is no consensus on how different apoE genotypes contribute to the pathogenesis of AD. The interrela ted studies proposed in the four cores and three projects of this P01 are anticipated to enhance our understanding of the differential effects of apoE isotypes on AD pathogenesis and accelerate the discovery of effective therapeutic approaches that address these diverse roles.

PI_NAMEs: WISNIEWSKI, THOMAS M (contact)

PROGRAM_OFFICER_NAME: YANG, AUSTIN JYAN-YU

PROJECT_TERMS: abeta deposition;abeta oligomer;Acceleration;Address;Advisory Committees;Affect;Age of Onset;aged;Alleles;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease related dementia;Amyloid;Amyloid beta-Protein;amyloid pathology;Animal Model;Animals;Apolipoprotein E;apolipoprotein E-3;apolipoprotein E-4;Apolipoproteins;Area;Automobile Driving;Awareness;Behavior;Behavior assessment;Behavioral;Binding;Bioinformatics;Biological Markers;Biometry;Biostatistical Methods;Blood Vessels;brain parenchyma;Cerebral Amyloid Angiopathy;Clinical;clinically relevant;Collaborations;Communities;Complex;Consensus;Coupling;Data;Data Analyses;data management;data sharing;Databases;Deposition;Development;Disease Progression;Education;Ensure;Experimental Designs;genetic risk factor;Genotype;glucose metabolism;Goals;Hemorrhage;human data;human tissue;Image;Immunology;immunoregulation;Immunotherapy;innovation;insight;Interdisciplinary Study;Label;laser capture microdissection;Late Onset Alzheimer Disease;Magnetic Resonance Imaging;meetings;Methodology;Methods;microPET;Mitochondria;Molecular Conformation;mouse model;neuroimaging;neuropathology;novel;novel strategies;novel therapeutics;operation;Pathogenesis;Pathology;Peptoids;Pharmaceutical Chemistry;Play;power analysis;programs;Progress Reports;Protein Conformation;Protein Isoforms;protein oligomer;Proteins;Proteome;Proteomics;Recording of previous events;Research;Research Personnel;response;Rodent Model;Role;Safety;Sampling;Senile Plaques;side effect;small molecule;Synaptic plasticity;synergism;tau Proteins;Techniques;Technology;Testing;Therapeutic;therapeutic development;therapeutically effective;therapy outcome;Transgenic Mice;Transgenic Organisms;treatment response;United States National Institutes of Health;Work

PROJECT_TITLE: Novel Approaches to Understand the Pathogenesis and Treat Alzheimer's Disease


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

PROJECT_TERMS: Accountability;Advisory Committees;Agreement;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease related dementia;Amyloid;Amyloid beta-Protein;Animal Model;Apolipoprotein E;Apolipoproteins;Automobile Driving;Bioinformatics;Biological;Biological Markers;Caregivers;Charge;chemical resource;Clinic;Cognitive;Collaborations;Communities;Data;Data Analyses;data management;data sharing;Development;Discipline;Disease;Disputes;Education;Ensure;Event;Experimental Designs;Fostering;Future;Goals;Grant;Health;Human Resources;human tissue;Immunology;immunoregulation;Institution;Interdisciplinary Study;knowledge base;meetings;Methodology;Methods;Molecular Conformation;mouse model;multidisciplinary;neuroimaging;Neurology;neuropathology;novel strategies;operation;Pathogenesis;Pathway interactions;Patients;Pharmaceutical Chemistry;Play;Policies;Positioning Attribute;pre-clinical;Program Research Project Grants;programs;Progress Reports;Protein Conformation;Protein Isoforms;Proteomics;Quality Control;Recording of previous events;Research;Research Personnel;Research Project Grants;Research Proposals;Resources;response;responsible research conduct;Role;Scientist;Series;Structure;success;synergism;tau aggregation;Therapeutic;therapeutic development;Translating;United States National Institutes of Health

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Cerebrovascular;Dementia;Immunization;Immunotherapy;Neurodegenerative;Neurosciences;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

PI_NAMEs: UEBERHEIDE, BEATRIX MAGDALENA (contact)

PROJECT_TERMS: 3xTg-AD mouse;AD transgenic mice;Affect;Affinity Chromatography;Aftercare;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease patient;Amyloid;Amyloid beta-Protein;Animal Disease Models;Antibodies;Apolipoprotein E;apolipoprotein E-2;apolipoprotein E-3;apolipoprotein E-4;APP-PS1;Autopsy;behavioral study;beta pleated sheet;Binding Proteins;Biology;Blood Vessels;blood-brain barrier crossing;Board Certification;Brain;brain tissue;Cerebral Amyloid Angiopathy;clinical practice;Cognitive;Collaborations;Data;data integration;Data Set;Development;Drug usage;Ensure;Equipment;experience;Freezing;Goals;Health;Human;Human Resources;human tissue;Immunoglobulin G;Immunoglobulin M;Immunotherapy;Injections;instrumentation;Label;Laboratories;laser capture microdissection;Lesion;Mass Spectrum Analysis;mild cognitive impairment;Molecular;Monoclonal Antibodies;mouse model;Mus;Neurodegenerative Disorders;Neurologist;neuropathology;Neurosciences;novel;novel strategies;Passive Immunotherapy;Pathogenesis;Pathway interactions;Patients;Peptides;Peptoids;Pharmaceutical Preparations;pre-clinical;Protein Analysis;Protein Isoforms;Proteins;Proteome;Proteomics;Publications;Reproducibility;Resources;Role;Sampling;Senile Plaques;small molecule;Standardization;tau-1;Technical Expertise;Therapeutic;Therapeutic antibodies;Tissue Sample;Tissues;Transgenic Mice;Work

PROJECT_TITLE: Proteomics/Neuropathology Core


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Drug Abuse (NIDA only);Emergency Care;Health Services;Opioid Misuse and Addiction;Opioids;Primary Health Care;Substance Misuse

ORG_CITY: SEATTLE

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Public Health Impact: Opioid Use Disorder (OUD) has emerged as a major US public health crisis, with over 2 million adults afflicted. The ED is a healthcare location where patients with OUD can be identified, evidence- based care initiated and treatment linkages proactively solidified. The systematic testing of the ED-LINC intervention, supported by the EDIE health information exchange platform, can begin to provide a critical evidence base that will enable emergency departments to better address the opioid epidemic.

PI_NAMEs: WHITESIDE, LAUREN K (contact)

PROGRAM_OFFICER_NAME: MARTIN, LINDSEY ANN

PROJECT_TERMS: Accident and Emergency department;acute care;Address;Adult;Alcohols;Ambulatory Care;American;Anxiety;Buprenorphine;care coordination;care seeking;Caring;Case Manager;Clinical;Clinical Trials;clinically relevant;collaborative care;college;comorbidity;comparative effectiveness trial;Complex;Computerized Medical Record;COVID-19 complications;COVID-19 pandemic;Data;Disease Management;Effectiveness;effectiveness testing;Elements;Emergency Care;Emergency Department Physician;Emergency department visit;Emergency Situation;evidence base;experience;follow-up;formative assessment;Goals;Health;health care delivery;health management;Health Professional;Health system;Healthcare;heroin use;high risk population;Home;Hospitals;illicit opioid;implementation intervention;implementation process;integrated care;Intervention;Location;longitudinal care;Managed Care;Medical;medication for opioid use disorder;member;Mental Depression;Mental Health;Methamphetamine;methamphetamine use;Methods;Modeling;Motivation;multi-component intervention;multidisciplinary;Naloxone;Notification;novel;Opioid;opioid epidemic;opioid overdose;opioid use;opioid use disorder;Outcome;Outcome Assessment;overdose education;overdose risk behaviors;Patient Care;patient engagement;patient oriented;Patient Self-Report;Patients;Penetrance;Pharmaceutical Preparations;Policies;Population;population health;pragmatic trial;primary medical care;Process Assessment;programs;Provider;Public Health;public health emergency;Randomized;randomized effectiveness trial;randomized trial;response;Sampling;scale up;secondary analysis;sex;sharing platform;substance use;substance use treatment;Supervision;support tools;symposium;Testing;Time;tool;treatment as usual;treatment effect;trial design;Washington

PROJECT_TITLE: The Emergency Department Longitudinal Integrated Care (ED-LINC) Effectiveness Randomized Trial Targeting Opioid Use and Related Comorbidity from the ED

STUDY_SECTION: HSOD

STUDY_SECTION_NAME: Health Services Organization and Delivery Study Section[HSOD]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: SAN FRANCISCO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: Project relevance  Pseudomonas aeruginosa is an environmental bacterium that is a leading cause of hospital acquired infections. Antibiotic resistance is rampant in P. aeruginosa, leading to limited therapeutic options. This grant seeks to understand how this bacterium responds to rapidly changing environments, which may lead to new therapeutic approaches to treat human infections.

PI_NAMEs: ENGEL, JOANNE N. (contact);PERSAT, ALEXANDRE

PROGRAM_OFFICER_NAME: ERNST, NANCY L

PROJECT_TERMS: Acute;Acute Pneumonia;Anti-Bacterial Agents;Antibiotic Resistance;Bacteria;Binding;Binding Proteins;Biology;Chemoreceptors;Chemotaxis;Complex;Cues;Cyclic AMP;demethylation;Environment;Enzymes;Escherichia coli;Event;Exhibits;Exposure to;Grant;Health;Homeostasis;Homologous Gene;Hour;Human;in vitro activity;Infection;Knowledge;Ligand Binding;Ligands;Link;Locomotion;mechanical signal;mechanotransduction;Mediating;memory process;Methylation;Methyltransferase;Modeling;Molecular;Motility;Motion;mouse model;Multi-Drug Resistance;mutant;Nosocomial Infections;novel;novel therapeutic intervention;Nutrient;opportunistic pathogen;Output;P-methyltransferase;Periodicity;Phosphorylation;Pilum;Process;Production;programs;protein-histidine kinase;Pseudomonas;Pseudomonas aeruginosa;Pseudomonas aeruginosa infection;Publishing;recruit;Regulation;response;Role;Rotation;Sensory;Short-Term Memory;Signal Transduction;Site;small molecule;Stimulus;Surface;Swimming;System;Testing;Therapeutic;Virulence

PROJECT_TITLE: Finding the way: Sensory adaptation during bacterial mechanotransduction

STUDY_SECTION: BV

STUDY_SECTION_NAME: Bacterial Virulence Study Section [BV]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

PI_NAMEs: MAR, ADAM CHRISTOPHER (contact)

PROJECT_TERMS: Alzheimer's Disease;Animals;Behavior;Behavior assessment;behavior test;Behavioral;behavioral phenotyping;Biological Markers;clinical investigation;clinical translation;Cognitive;cognitive testing;Cost efficiency;Dedications;Goals;Housing;Human;Human Resources;immunological intervention;Immunologics;innovation;Laboratories;mouse model;Mus;mutant;Neurodegenerative Disorders;novel strategies;Pathogenesis;Pathologic;pharmacologic;Phenotype;Process;Research;Rodent;Standardization;Sum;Testing;Time;touchscreen;Transgenic Mice;Transgenic Organisms

PROJECT_TITLE: Transgenic/Behavior Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biotechnology;Brain Disorders;Data Science;Dementia;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences

PI_NAMEs: SHAO, YONGZHAO  (contact)

PROJECT_TERMS: Adoption;Algorithmic Analysis;Alzheimer's Disease;American;animal data;Animals;Behavioral;Bioinformatics;bioinformatics pipeline;Biological Markers;Biometry;clinically relevant;Collaborations;Communities;computer framework;computerized tools;Consultations;Data;Data Analyses;Data Collection;data integration;data management;Data Set;data sharing;Databases;Doctor of Philosophy;Electrons;Ensure;experience;Funding;Genes;genome resource;Genomics;Human;human tissue;In Vitro;in vivo;Informatics;innovation;insight;Investigation;ionization;Knowledge Portal;Laboratories;Laboratory Study;large scale data;Leadership;Maps;Mass Fragmentography;mass spectrometer;Mass Spectrum Analysis;Measurement;medical schools;Messenger RNA;metabolomics;Metadata;MicroRNAs;Mission;Multiomic Data;multiple omics;Mus;novel;novel strategies;Online Systems;Ontology;Outcome;Pathogenesis;Pathway Analysis;professor;Proteins;Proteomics;public repository;Publications;Publishing;Randomized;Records;Reporting;repository;Reproducibility;Research;Research Design;Research Personnel;Research Project Grants;Sampling;Services;shared repository;small molecule;Source;Statistical Data Interpretation;Statistical Models;statistics;synergism;System;Time;transcriptomics;Transgenic Animals;translational study;Visualization;Visualization software

PROJECT_TITLE: Biostatistics/Bioinformatics Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Cerebrovascular;Dementia;Neurodegenerative;Neurosciences;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

PROJECT_TERMS: Affect;Affinity Chromatography;Age;Age of Onset;alpha synuclein;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer’s disease biomarker;Amyloid;Amyloid beta-Protein;Apolipoprotein E;apolipoprotein E-3;apolipoprotein E-4;Astrocytes;Automobile Driving;Behavioral;Binding Proteins;Bioinformatics;Biometry;Brain;brain tissue;Cell Culture Techniques;Cerebral Amyloid Angiopathy;Co-Immunoprecipitations;Cognitive;comparative;Data;Data Set;Development;Disease;Disease Progression;disorder subtype;Future;Genes;Genotype;Heterogeneity;Human;human data;Immunohistochemistry;Impaired cognition;Individual;insight;interest;Lesion;Mass Spectrum Analysis;Microglia;Microvascular Dysfunction;mild cognitive impairment;mouse model;Neurites;neuropathology;new therapeutic target;novel;novel strategies;novel therapeutics;Onset of illness;Pathogenesis;Pathway interactions;Patients;Persons;Play;pre-clinical;Protein Isoforms;Proteins;Proteome;Proteomics;Risk Factors;Rodent;Role;Senile Plaques;Severities;Signal Pathway;Subgroup;sulfated glycoprotein 2;tau Proteins;Techniques;Testing;therapeutic biomarker;therapeutic candidate;Therapeutic Intervention;Tissues;transcriptomics;Transgenic Organisms;Ubiquitin;Validation;Variant

PROJECT_TITLE: Proteomic studies on the role of Apolipoprotein E and other amyloid associated proteins in AD


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Biotechnology;Brain Disorders;Cerebrovascular;Dementia;Genetics;Neurodegenerative;Neurosciences;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

PROJECT_TERMS: 3xTg-AD mouse;abeta accumulation;Abeta synthesis;Affect;aged;Alleles;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Amino Acids;Amyloid;Amyloid beta-Protein;Amyloid deposition;amyloid pathology;antagonist;Antibodies;ApoE knockout mouse;Apolipoprotein E;apolipoprotein E-3;apolipoprotein E-4;APP-PS1;behavioral study;Binding;Biochemical;Biochemistry;Biological;Blood - brain barrier anatomy;Blood Vessels;blood-brain barrier penetration;Brain;Cells;Cerebral Amyloid Angiopathy;Chimera organism;Cholesterol;Custom;Data Analytics;data integration;Databases;design;Development;dosage;Drug Kinetics;Drug Targeting;drug-like compound;Ensure;experimental study;genetic risk factor;Geometry;Human;human tissue;Immunotherapy;improved;in silico;In Vitro;in vivo;in vivo evaluation;inhibitor;innovation;insight;Knock-in;Knock-in Mouse;Knock-out;Late Onset Alzheimer Disease;Lead;Libraries;Ligand Binding;Location;Magnetic Resonance Imaging;Mediating;microCT;microPET;Mole the mammal;Mus;neuroinflammation;Neurons;novel;novel strategies;novel therapeutic intervention;Parents;Pathogenesis;Pathologic;Pathology;Pathway interactions;Peptides;Peptoids;Periodicity;Permeability;Pharmaceutical Chemistry;Pharmaceutical Preparations;Phenylalanine;Plasma;Process;Proteome;Proteomics;receptor;Resistance;response;Safety;scaffold;screening;self assembly;Senile Plaques;small molecule;Structure;Synapses;tau Proteins;Techniques;Testing;therapeutic effectiveness;Toxic effect;transgenic model of alzheimer disease;Transgenic Organisms;treatment effect;Treatment Efficacy;β-amyloid burden

PROJECT_TITLE: Blocking the binding of Aβ and apoE as a novel therapeutic approach for AD


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Cerebrovascular;Dementia;Immunization;Immunotherapy;Neurodegenerative;Neurosciences;Prevention;Vaccine Related;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

PI_NAMEs: GONI, FERNANDO  (contact)

PROJECT_TERMS: 3xTg-AD mouse;abeta oligomer;Active Immunization;Affect;Alzheimer's Disease;Alzheimer's disease model;Amyloid;Amyloid beta-Protein;amyloid structure;Animal Model;Animals;Antibodies;Antibody Binding Sites;Antibody Response;Apolipoprotein E;Apolipoproteins;APP-PS1;Autoimmune;autoimmune toxicity;Behavioral;beta pleated sheet;Binding;Binding Sites;Biochemical;Biological Markers;Blood - brain barrier anatomy;Blood Vessels;blood-brain barrier crossing;blood-brain barrier penetration;Brain;Cerebral Amyloid Angiopathy;Cerebrovascular system;Characteristics;Clinical Trials;Cognitive;cognitive testing;Complication;conformer;Crossbreeding;Elderly;extracellular;Female;Future;Hemorrhage;Human;human tissue;hyperphosphorylated tau;Image;Immune Targeting;Immunization;Immunoglobulin G;Immunoglobulin M;Immunoglobulins;immunological intervention;immunoregulation;Immunotherapy;Injections;innovation;insight;Intraperitoneal Injections;Kinetics;Knock-in;Legal patent;male;Mass Spectrum Analysis;Measures;Mediating;misfolded protein;Modeling;Molecular Conformation;Monoclonal Antibodies;monomer;mouse model;Mus;nanomolar;Neurodegenerative Disorders;Neurofibrillary Tangles;neuropathology;novel strategies;Passive Immunization;Passive Immunotherapy;Pathogenesis;Pathologic;Pathology;Peptoids;Peripheral;Permeability;prion-like;Proteome;Proteomics;Reporting;Safety;Senile Plaques;side effect;small molecule;Sterility;Structure;tau aggregation;tau Proteins;Testing;Therapeutic Effect;Toxic effect;vascular abnormality;Western Blotting

PROJECT_TITLE: Immunomodulation targeting abnormal conformation and the influence of apoE


ADMINISTERING_IC: HL

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: ATHENS

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF GEORGIA

ORG_STATE: GA

PHR: PROJECT NARRATIVE The ideal antibacterial and hemocompatible surface would prevent bacterial biofilm formation as well as platelet adhesion and activation. This research project will develop and evaluate a catheter hub disinfection device designed using the synergistic effects of a photoinitiated S-nitrosothiol based nitric oxide (NO) release polymer that can provide continuous therapeutic NO levels at the catheter interface. These materials and devices will be studied for their prevention of microbial infection and platelet activation/adhesion, thereby solving major clinical problems of thrombosis and infection associated with long-term intravascular catheter devices.

PI_NAMEs: BRISBOIS, ELIZABETH JOY (contact)

PROGRAM_OFFICER_NAME: DANTHI, NARASIMHAN

PROJECT_TERMS: Adhesions;analytical method;Anti-Bacterial Agents;Antibiotics;Anticoagulation;antimicrobial;Antimicrobial Effect;Bacteremia;Bacteria;Bacterial Infections;Binding;biomaterial compatibility;Bioreactors;Blood;Blood Circulation;Blood Platelets;Blood Vessels;Blood-Borne Pathogens;catheter related infection;Catheter-related bloodstream infection;Catheters;Cell Line;Cells;Cessation of life;Clinical;clinical application;clinical translation;Coagulation Process;Conscious;cost;covalent bond;data integration;Development;Device Designs;Devices;Disinfection;early phase clinical trial;Embolism;Exposure to;Fiber Optics;Generations;Goals;Health Care Costs;Healthcare Industry;hemocompatibility;Heparin;Hour;Immobilization;implantable device;improved;In Vitro;in vitro Bioassay;Indwelling Catheter;Infection;Infection prevention;Intensive Care Units;Klebsiella pneumoniae;Lead;Legal patent;Length;Life;Local Anti-Infective Agents;Measures;Medical;Medical Device;microbial;Microbial Biofilms;migration;Modeling;N-acetylpenicillamine;Nitric Oxide;Nitric Oxide Donors;Obstruction;Oryctolagus cuniculus;Patient Care;Patients;Peripheral;photoactivation;Physiological;Platelet Activation;Polymers;portability;prevent;Prevention;Property;Pseudomonas aeruginosa;Research Project Grants;Risk;S-Nitrosothiols;Safety;Sepsis;Side;Staphylococcus aureus;Staphylococcus epidermidis;Sterilization;success;Surface;Technology;Testing;Therapeutic;Thrombosis;thrombotic;thrombotic complications;Thrombus;Translations;United States;Vascular Endothelial Cell;Venous;Work

PROJECT_TITLE: Prevention of catheter related infections via photoactive nitric oxide delivery device


NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Genetics;Heart Disease;Muscular Dystrophy;Myotonic Dystrophy;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Project Narrative: One of the most problematic and least understood aspect of myotonic dystrophy type 1 (DM1), the most common muscular dystrophy in adults and children, is the heart problems in DM1, which are a leading cause of sudden death in patients. We will use a mouse model of RNA toxicity in DM1 to study its effect on the heart. Our goals are: 1) characterize and understand the drivers of this pathology in the heart, and 2) study the heart’s response to potential treatments under development.

PI_NAMEs: MAHADEVAN, MANI SUBRAMANIAM (contact)

PROGRAM_OFFICER_NAME: LI, HUIQING

PROJECT_TERMS: Ablation;Adult;Affect;Alleles;Antibodies;Antisense Oligonucleotide Therapy;Antisense Oligonucleotides;Arrhythmia;Attention;autosome;Behavior;behavioral study;Biological Assay;Biological Markers;Breeding;Cardiac;cardiac magnetic resonance imaging;Cardiac Myocytes;Cause of Death;Child;Clinical;Clinical Pathology;Clinical Research;Collaborations;coronary fibrosis;Data;Defect;Degenerative Disorder;Development;Dominant Genetic Conditions;Dose;Doxycycline;Electrocardiogram;Fatty Acids;Fibrosis;functional outcomes;Future;Gene Deletion;Gene Expression;Genes;Genetic Diseases;Goals;Grant;Heart;heart defect;Heart Diseases;Histology;Individual;inducible Cre;Infiltration;insight;interest;interstitial;Ligands;Lipid Inclusion;LoxP-flanked allele;Maintenance;Mediating;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;Muscle;Muscular Dystrophies;mutant;Myotonic Dystrophy;myotonic dystrophy protein kinase;Myotonic dystrophy type 1;Nature;next generation;novel;Nuclear;Organ;Outcome;Pathogenesis;Pathogenicity;Pathologic;Pathology;Pathway interactions;Patients;Pharmacologic Substance;Phenotype;Platelet-Derived Growth Factor alpha Receptor;Pre-Clinical Model;Production;progenitor;Proliferating;Protein Isoforms;receptor;Reporting;response;RNA;Role;Signal Transduction;Stains;stem cells;Sudden Death;Symptoms;System;Tamoxifen;targeted treatment;Testing;Therapeutic;Therapeutic Effect;Therapeutic Studies;therapeutic target;Time;Tissues;tool;Toxic effect;Transforming Growth Factor beta;Transforming Growth Factor Beta 2;Transgenes;treatment response

PROJECT_TITLE: The role of TGFβs and cFAPs in Cardiac Pathology from RNA Toxicity

STUDY_SECTION: TDPS

STUDY_SECTION_NAME: Therapeutic Development and Preclinical Studies Study Section[TDPS]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Disorders;Genetics;Human Genome;Mental Health;Mental Illness;Neurosciences

ORG_CITY: CAMBRIDGE

ORG_NAME: BROAD INSTITUTE, INC.

ORG_STATE: MA

PHR: NARRATIVE This project will harmonize genomic data from >2.6 million individuals to create large and diverse maps of structural rearrangements in the genome and use novel statistical methods to determine which genomic regions are intolerant to such alterations. It will then apply these new methods, measures of intolerance, and variants discovered from new technologies to genomic data from almost 400,000 cases with a diverse range of neuropsychiatric conditions to better disentangle the influence of genetic variation on these conditions.

PI_NAMEs: TALKOWSKI, MICHAEL E (contact)

PROGRAM_OFFICER_NAME: PEVSNER, JONATHAN ABRAM

PROJECT_TERMS: Address;aggregation database;Algorithms;All of Us Research Program;Alleles;analytical method;Architecture;Area;autism spectrum disorder;biobank;Biology;Bipolar Disorder;case control;Cells;Clinical;Code;Cognitive;cohort;Collection;Complement;Complex;computational pipelines;Copy Number Polymorphism;Data;Data Set;Development;Dimensions;Disease;disorder risk;diverse data;dosage;Emerging Technologies;Epilepsy;Etiology;exome;exome sequencing;Exons;Family;Frequencies;Funding;General Population;Genes;genetic architecture;Genetic Predisposition to Disease;Genetic Variation;Genets;Genome;genome sequencing;genome-wide;genomic data;Genomic Segment;genomic variation;Genomics;Genotype;Goals;Human;human disease;Human Genome;Individual;innovation;Joints;loss of function mutation;Maps;Measures;Mediating;member;Mendelian disorder;Methods;Modeling;Mutation;Nature;Nervous System Disorder;neuropsychiatric disorder;neuropsychiatry;new technology;novel;novel strategies;Nucleotides;Phenotype;Point Mutation;polygenic risk score;Population;Population Heterogeneity;Process;Research;Research Project Grants;Resolution;Resources;Risk Factors;Sampling;Schizophrenia;Science;sex;Short Tandem Repeat;Single Nucleotide Polymorphism;Source;Statistical Methods;Statistical Models;Structural Models;success;Technology;tool;Untranslated RNA;Variant

PROJECT_TITLE: Scalable tool and comprehensive maps to interpret structural variation across the neuropsychiatric spectrum

STUDY_SECTION: GCAT

STUDY_SECTION_NAME: Genomics, Computational Biology and Technology Study Section[GCAT]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Cancer;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Genetics;Infectious Diseases;Precision Medicine;Radiation Oncology;Rare Diseases;Sexually Transmitted Infections

ORG_CITY: PITTSBURGH

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE This project studies a new pathway that links p16 to outcome in head and neck cancer independent of HPV status via repression of homologous recombination. Tumors with activation of this pathway signaling are sensitive to radiation and PARP inhibition, while tumors that do not have this pathway activated can be treated with drugs currently in clinical development that specifically inhibit ubiquitin-specific protease 7 (USP7) to make them sensitive to both treatments. This project will lead to an ability to predict which head and neck cancer patients will respond to current therapy and which will benefit from the addition of USP7 inhibition to their treatment.

PI_NAMEs: SKINNER, HEATH DEVIN (contact)

PROGRAM_OFFICER_NAME: CHEN, ZHONG

PROJECT_TERMS: arm;Automobile Driving;Biological Markers;brca gene;BRCA1 gene;Bypass;Cancer Biology;cancer cell;Cancer Control;Cancer Model;Cell Cycle;Cell Cycle Arrest;Cells;Cessation of life;ChIP-seq;Cisplatin;Clinical;clinical development;Clinical stratification;cohort;Coupled;Cyclin-Dependent Kinase Inhibitor 2A;Data;Diagnosis;Disease;DNA Damage;DNA Repair;Down-Regulation;Exhibits;genetic signature;Head and Neck Cancer;head and neck cancer patient;Head and Neck Squamous Cell Carcinoma;homologous recombination;HPV negative;HPV-negative head and neck cancer;Human Papillomavirus;Immunocompetent;immunodeficiency;Immunohistochemistry;improved;In Vitro;in vitro Assay;Incidence;inhibitor;Left;Link;Mass Spectrum Analysis;Mediating;Mental Depression;Messenger RNA;Methodology;Modeling;mouse model;Mus;Nature;Nonhomologous DNA End Joining;novel;novel therapeutics;oral HPV-positive head and neck cancers;Oropharyngeal;Oropharyngeal Neoplasms;Outcome;overexpression;PARP inhibition;Pathway interactions;Patient-Focused Outcomes;Patients;Persons;Pharmaceutical Preparations;Poly(ADP-ribose) Polymerase Inhibitor;Pre-Clinical Model;precision medicine;precision oncology;Proteins;Quality of life;Radiation;radiation response;Radiation therapy;Radiation Toxicity;Recurrence;Repression;Resistance;response;Salivary;Signal Pathway;Signal Transduction;Sp1 Transcription Factor;standard of care;Suicide;Survivors;Testing;therapy resistant;Toxic effect;transcriptome sequencing;treatment response;tumor;ubiquitin-protein ligase;ubiquitin-specific protease;Up-Regulation;Work

PROJECT_TITLE: Targeting non-canonical p16 signaling to improve radiation response and outcome in head and neck cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CTH-S(02)M]


ADMINISTERING_IC: NS

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: LA JOLLA

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative Dysregulated cholesterol metabolism is associated with Alzheimer’s Disease (AD) pathology but the outcomes of these alterations and which cell types are responsible for them are still unclear. Astrocytes, non-neuronal glial cells that regulate neuronal function, are the main producers of brain cholesterol and are also affected in AD. The proposed project will investigate how cholesterol synthesis, trafficking, and secretion is altered in AD astrocytes and will identify potential targets for treatment of AD and other age-related neurodegenerative diseases.

PI_NAMEs: BURGADO, JILLYBETH  (contact)

PROGRAM_OFFICER_NAME: ULLRICH, LAUREN ELIZABETH

PROJECT_TERMS: Address;Adoption;Affect;Age;age related neurodegeneration;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease therapeutic;American;Apolipoproteins;Astrocytes;Behavioral;Bioinformatics;Biological;Biological Assay;Biology;Blood Vessels;Brain;candidate identification;career;Cause of Death;Cell Communication;cell type;Cells;Cholesterol;Cholesterol Homeostasis;Communication;comparison control;Cytokine Signaling;Data;Data Set;Databases;Dementia;Development;Diagnosis;Disease;Doctor of Philosophy;effective therapy;Environment;Exhibits;Experimental Designs;experimental study;Exposure to;Extracellular Matrix;Functional disorder;Generations;Genes;global health;Goals;Health;Homeostasis;human stem cells;Impairment;In Vitro;in vivo;in vivo Model;Individual;Induced Neurons;induced pluripotent stem cell;Inflammation;Inflammatory;knock-down;Laboratories;Life;lipid metabolism;lipid transport;Lipids;Lipoproteins;Measures;Membrane;Metabolic;Metabolic Pathway;Metabolism;metabolomics;mouse model;multi-electrode arrays;Multiomic Data;multiple omics;Nerve Degeneration;Neurites;Neurodegenerative Disorders;Neuroglia;neuron loss;Neuronal Dysfunction;Neurons;Neurosciences;neurotoxic;novel;Outcome;overexpression;Pathology;Pathway interactions;Patients;Phase;Phenotype;Physiological;Play;post-doctoral training;Postdoctoral Fellow;postsynaptic;presynaptic;prevent;Principal Investigator;Property;Proteome;Regulation;Research;Research Personnel;Research Project Grants;response;Role;Signal Transduction;Signaling Molecule;skills;Source;stable isotope;stem cell model;Synapses;Synaptic Transmission;synaptogenesis;System;Technical Expertise;Techniques;trafficking;Training;transcriptome;Transgenic Mice;Transgenic Model;United States;uptake;Viral;Wild Type Mouse

PROJECT_TITLE: Dysregulated cholesterol metabolism in Alzheimer's Disease astrocytes: Investigating contributions to neuronal dysfunction


ADMINISTERING_IC: MD

ED_INST_TYPE: OVERALL MEDICAL

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: FORT WORTH

ORG_NAME: UNIVERSITY OF NORTH TEXAS HLTH SCI CTR

ORG_STATE: TX

PHR: Project Narrative The goal of the Texas MiHERO program is to utilize the John Lewis NIMHD Endowment funding to build capacity and infrastructure at the UNTHSC for its nationally recognized health disparities research, training and outreach activities, specifically in recruiting and training more minority faculty and PhD students. Through an innovative interdisciplinary research leaders program, a faculty scholarship program and training PhD students in minority health and health disparities, MiHERO will enable transdisciplinary, interprofessional collaborations and novel approaches to understanding minority health and eliminate health disparities.

PI_NAMEs: VISHWANATHA, JAMBOOR K. (contact)

PROGRAM_OFFICER_NAME: JONES, NANCY LYNNE

PROJECT_TERMS: Address;Affect;Area;Awareness;Behavioral;Behavioral Research;Biomedical Research;Cardiovascular Diseases;career;Caring;Chronic Disease;Clinical Research;cohort;Collaborations;community engagement;community organizations;Diabetes Mellitus;Disabled Persons;disadvantaged background;Disease;Disparity;Disparity population;Doctor of Philosophy;doctoral student;Economically Deprived Population;Education;Education and Outreach;Educational Curriculum;Endowment;Ensure;ethnic minority;Ethnic Population;experience;Faculty;Fellowship;Foundations;Funding;Funding Mechanisms;Goals;graduate student;Health;Health Disparities Research;health disparity;Health education;Health Professional;Health Sciences;HIV;Human;Hypertension;improved;Income;Individual;Infrastructure;innovation;Institution;Interdisciplinary Study;Leadership;Learning;Malignant Neoplasms;Medical;medically underserved;member;Mentors;Minority;Minority Groups;minority health;minority health disparity;Minority Health Research;Modeling;Monitor;National Institute on Minority Health and Health Disparities;novel strategies;outreach;outreach program;Participant;Performance;Physicians;Policies;Population;Program Development;Program Sustainability;programs;racial minority;racial population;recruit;Research;Research Personnel;Research Project Grants;Research Training;Rural Population;rural underserved;Scholarship;Scientific Advances and Accomplishments;Scientist;Secure;Societies;socioeconomic disadvantage;Specialized Center;Stroke;Teacher Professional Development;Texas;Training;training opportunity;undergraduate student;Underrepresented Minority;Underrepresented Populations;Underrepresented Students;Universities;Vulnerable Populations

PROJECT_TITLE: Texas Minority Health, Research and Outreach (MiHERO)


NIH_SPENDING_CATS: Bioengineering;Biotechnology;HIV/AIDS;Human Fetal Tissue;Immunization;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS;Women's Health Research

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative  Adeno associated virus (AAV) vectors can be used to deliver broadly neutralizing antibodies (bNAbs) against human immunodeficiency virus (HIV) to prevent transmission in animal models, making them promising candidates for HIV prevention. In this proposal, we will determine how the immune system interacts with next-generation bNAbs to prevent HIV transmission. This work will deepen our understanding of the immune protection from HIV and yield new AAV vectors that deliver bNAbs engineered for maximal preventative efficacy.

PI_NAMEs: BALAZS, ALEJANDRO BENJAMIN (contact)

PROGRAM_OFFICER_NAME: SINGH, ANJALI

PROJECT_TERMS: Address;adeno-associated viral vector;AIDS prevention;Animal Experiments;Animal Model;Antibodies;antibody engineering;antibody-dependent cell cytotoxicity;antibody-dependent cellular phagocytosis;Antibody-mediated protection;Automobile Driving;Binding;Biological Assay;BLT mice;Bone Marrow;Cell Physiology;Cell surface;Cells;Clinical Trials;comparative efficacy;Data;delivery vehicle;Dependovirus;Doctor of Philosophy;Effectiveness;Effector Cell;Engineering;Epitopes;Exhibits;Future;Gene Transfer;Grant;HIV;HIV Infections;HIV therapy;Human;humanized mouse;Immune;Immune system;Immunity;immunoengineering;Immunoglobulin Fragments;Immunoglobulin G;immunoprophylaxis;In Vitro;in vitro Assay;in vivo;Individual;Infection;innate immune function;innate immune mechanisms;Liver;Macrophage;Measures;Mediating;medical schools;Membrane Fusion;Modeling;Mutation;Natural Immunity;Natural Killer Cells;Neutralization Tests;neutralizing antibody;Neutralizing antibody assay;next generation;novel;Patients;Pattern;Phagocytosis;Population;prevent;Prevention;Principal Investigator;professor;protective efficacy;receptor;receptor binding;Research;Role;Satellite Viruses;Serum;Side;Specificity;Surface;Technology;Testing;Thymus Gland;transmission process;Vagina;vaginal transmission;vector;Viral;Viremia;Work

PROJECT_TITLE: AAV Vectored Delivery of Broadly Neutralizing Antibodies with Optimal Innate Functionality Against HIV

STUDY_SECTION: HVCD

STUDY_SECTION_NAME: HIV Molecular Virology, Cell Biology, and Drug Development Study Section[HVCD]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Bioengineering;Digestive Diseases;Inflammatory Bowel Disease;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: Boulder

ORG_NAME: UNIVERSITY OF COLORADO

ORG_STATE: CO

PHR: NARRATIVE The small intestine has a crypt-villus structure that not only digests and absorbs nutrients, but also serves as a barrier to infections from the outside world. To maintain these functions throughout a lifetime and repair damaged intestinal tissue, crypts regenerate by dividing in a process called fission, and if this process goes awry, diseases like Crohn’s disease or Ulcerative Colitis can arise. To better understand crypt fission and its importance in intestinal tissue regeneration, we will develop an in vitro intestinal organoid model to study the dynamics of crypt formation and fission during injury and repair.

PI_NAMEs: ANSETH, KRISTI S. (contact);DEMPSEY, PETER J

PROGRAM_OFFICER_NAME: GREENWEL, PATRICIA

PROJECT_TERMS: Adhesives;Alleles;base;Biomechanics;Cell Compartmentation;Cell Physiology;Cell secretion;Cell Shape;cell type;Cells;Cellularity;Complex;Crohn's disease;crypt cell;Daughter;density;Development;Digestion;Disease;Engineering;Epithelial Cells;Epithelium;Event;experimental study;extracellular;Extracellular Matrix;Geometry;Health;Homeostasis;Hydrogels;In Vitro;in vitro Model;in vivo;in vivo Model;Infection;Inflammatory Bowel Diseases;Injury;injury and repair;innovation;Integrin Binding;intercellular communication;intestinal crypt;Intestinal Diseases;Intestines;knock-down;Label;Letters;LGR5 gene;Light;Location;Maintenance;Malignant Neoplasms;mechanotransduction;Mediating;Membrane;Microscopy;Modeling;Modulus;mouse model;Mus;Myosin Heavy Chains;Natural regeneration;Nuclear;Nutrient;nutrient absorption;Organoids;Paneth Cells;Parents;Pattern;Peptides;Positioning Attribute;Process;Property;Protein Secretion;repaired;Reporter;Reproducibility;Research;Resolution;response;Role;Shapes;Signal Transduction;Small Intestines;spatiotemporal;stem cell niche;stem cells;Structure;Tamoxifen;Testing;Three-Dimensional Imaging;Time;tissue regeneration;Tissues;two-photon;Ulcerative Colitis;unnatural amino acids;Validation;Villus

PROJECT_TITLE: Photoresponsive materials to study matricellular signaling dynamics during crypt formation and fission

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Patient Safety;Precision Medicine

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Our Consortium will continue its long- standing contribution to the drug development efforts of the NCI by  leveraging its collective experience, commitment to collaboration, and legacy of training young investigators to  impact the clinical care of cancer patients. We promote inclusiveness of the many medical disciplines that are  required to conduct innovative, informative, and insightful early phase clinical trials. We anticipate enhanced  interactions with the National Clinical Trials Network to bring forward successes from the efforts of the ETCTN.

PI_NAMEs: BEUMER, JAN HENDRIK;CARDUCCI, MICHAEL A (contact);GENTZLER, RYAN ;LIU, GLENN ;MESSERSMITH, WELLS A.;RUIZ, JIMMY

PROGRAM_OFFICER_NAME: IVY, S PERCY

PROJECT_TERMS: Acceleration;assay development;Biological;Biological Assay;Biological Markers;biomarker development;biomarker validation;Biopsy Specimen;Cancer Center;cancer clinical trial;Cancer Patient;Cancer Therapy Evaluation Program;career;Characteristics;Clinical;clinical care;clinical development;clinical investigation;Clinical Investigator;Clinical Research;clinical translation;Clinical Trials;Clinical Trials Network;Collaborations;Collection;Comprehensive Cancer Center;data sharing;design;Development;Discipline;Disease;drug development;Drug resistance;drug sensitivity;early phase clinical trial;early phase trial;Educational Activities;Eligibility Determination;Environment;Evaluation;Evolution;experience;Fostering;Goals;Good Clinical Practice;Grant;Image;Immunologic Monitoring;Infrastructure;innovation;Institution;interest;Intervention;Investigational Therapies;Kimmel Cancer Center at the Thomas Jefferson University;Laboratories;Laboratory Study;Lead;Leadership;Letters;Location;Malignant Neoplasms;Medical;meetings;member;Memorial Sloan-Kettering Cancer Center;Mentors;Methodology;Molecular;molecular subtypes;National Clinical Trials Network;NCI-Designated Cancer Center;New Agents;next generation;novel;novel anticancer drug;novel therapeutics;Organizational Affiliation;Participant;participant enrollment;Pathologist;Pathway interactions;patient population;Patient Selection;Patients;Pharmacodynamics;Phase;Phase I Clinical Trials;Protocols documentation;Quality of Care;radiologist;rare cancer;Research;Research Personnel;Resource Sharing;Resources;response;Rural;Science;Site;Statistical Data Interpretation;stem;success;Team Process;Toxic effect;Training;Translating;Translational Research;trial design;Universities;University of Virginia Cancer Center;Wisconsin

PROJECT_TITLE: The Johns Hopkins Translational Science Team and Consortium for ETCTN Studies


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Data Science;Dementia;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Precision Medicine;Prevention

ORG_DEPT: PEDIATRICS

PHR: PROJECT NARRATIVE Alzheimer’s Disease is difficult to study due to its heterogeneity and lack of integration between molecular and clinical datasets. This research proposal aims to enable precision medicine approaches for Alzheimer’s Disease by utilizing integrative networks on a large set of clinical data to identify potential clinical and molecular associations. Ultimately, this project will facilitate the identification of hypotheses for disease mechanisms underlying heterogeneous clinical manifestations, providing a step towards improved patient stratification and personalized treatment approaches.

PI_NAMEs: TANG, ALICE SUMMER (contact)

PROGRAM_OFFICER_NAME: LUO, YUAN

PROJECT_TERMS: Address;Aging;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease model;Alzheimer's disease patient;Alzheimer's disease risk;Animal Model;Big Data;Biological;California;Caregivers;Classification;Clinical;Clinical Data;Cluster Analysis;Complex;Computerized Medical Record;cost;Data;Data Set;data warehouse;Databases;Dementia;Development;Diagnosis;Dimensions;Disease;disease heterogeneity;Disease Progression;disorder risk;disorder subtype;European;experience;Genetic;Genomics;Goals;health data;Heterogeneity;Histopathology;human data;Image;Impaired cognition;improved;individual variation;Informatics;insight;interdisciplinary approach;Knowledge;knowledge network;Link;machine learning method;Memory;Mentorship;Modality;Modeling;Molecular;molecular domain;multimodality;multiple omics;Nerve Degeneration;Neurodegenerative Disorders;Neurofibrillary Tangles;Onset of illness;Output;Pathway interactions;patient stratification;Patients;personalized medicine;personalized therapeutic;Pharmaceutical Preparations;Phenotype;phenotypic data;Physicians;precision medicine;predictive modeling;Prevalence;Research;Research Proposals;resilience;Risk;Scientist;Senile Plaques;sex;Sex Differences;Specific qualifier value;Stratification;tau Proteins;Time;Training;transcriptomics;unsupervised learning;Validation;Visualization;Work

PROJECT_TITLE: Leveraging Clinical Data for Phenotyping and Predictive Modelling of Alzheimer’s Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F18-E(20)L]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Immunotherapy;Infectious Diseases;Influenza;Lung;Pneumonia and Influenza

ORG_CITY: BATON ROUGE

ORG_NAME: LOUISIANA STATE UNIV A&M COL BATON ROUGE

ORG_STATE: LA

PHR: Project Narrative  Influenza (flu) infection is a leading cause of respiratory disease and death worldwide, causing 3-5 million cases of severe illness and more than 250,000 deaths during an average flu season, in which severe influenza diseases are accompanied by an aggressive pro-inflammatory response and an insufficient anti- inflammatory immunity. The production of the immunosuppressive cytokine IL-10 by effector T cells is critical in limiting the immunopathology during flu infection, however, our understanding of how this immunomodulatory event is regulated is very limited. The proposed research will define the biomarkers of regulatory CD8+ T cells, as well as transcriptional mechanisms how these cells develop and function, which will generate key information to help facilitate our understanding and enhance ability of modulating immune regulation to limit immunopathology, morbidity and mortality during flu infection.

PI_NAMEs: HUANG, WEISHAN  (contact)

PROGRAM_OFFICER_NAME: ARNOLD, MICHELLE MARIE

PROJECT_TERMS: Acute;adaptive immune response;Adaptive Immune System;Adoptive Cell Transfers;airway inflammation;Anti-Inflammatory Agents;Antigens;ATAC-seq;Binding;Binding Sites;Biochemical;Biological Markers;Biological Response Modifiers;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell model;Cells;Cessation of life;ChIP-seq;congenic;Coronavirus;cytokine;Data;Detection;Development;Disease;DNA Binding;effector T cell;Event;Exhibits;experimental study;Extrinsic allergic alveolitis;flu;FOXP3 gene;genetic approach;Genetic Polymorphism;Genetic Transcription;Genomic approach;Human;IL10 gene;IL2RA gene;Immunity;immunopathology;immunoregulation;Immunosuppression;In Vitro;in vivo;Individual;Infection;Inflammatory;Inflammatory Response;Influenza;Influenza A virus;influenza epidemic;influenza infection;influenza virus strain;Innate Immune Response;Innate Immune System;innovation;Interleukin-10;Learning;Lung;Macrophage;Memory;Modeling;Molecular;Molecular Profiling;Morbidity - disease rate;mortality;mouse model;Mus;novel;Organ;pandemic disease;Pathogenesis;Pathogenicity;Pathway interactions;Peptides;Peripheral Blood Mononuclear Cell;phenotypic biomarker;Population;Production;Protocols documentation;PTPRC gene;Recovery;Regulation;Regulatory T-Lymphocyte;Reporter;Repression;Research;Respiratory Disease;Risk;Role;screening;seasonal influenza;Signal Pathway;Signal Transduction;Surface;T cell differentiation;T-Cell Development;T-Cell Proliferation;T-Lymphocyte;TCF Transcription Factor;Therapeutic;Transcriptional Regulation;transcriptome sequencing;Transgenic Mice;Viral;Virus;Virus Diseases;Work

PROJECT_TITLE: Markers and regulation of regulatory CD8+ T cells during influenza-induced lung immunopathology

STUDY_SECTION: IHD

STUDY_SECTION_NAME: Immunity and Host Defense Study Section[IHD]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Genetics

ORG_DEPT: PHARMACOLOGY

PHR: Project Narrative During cell division, each daughter cell must inherit exactly one copy of each chromosome as errors can lead to cancer and birth defects. Two large cellular machines are responsible for segregating chromosomes: the spindle and kinetochore. Here we probe how these machines’ building blocks together give rise to their function, aiming to uncover the mechanical design principles driving chromosome segregation and to ultimately better target dividing cells for therapeutic purposes.

PI_NAMEs: DUMONT, SOPHIE  (contact)

PROGRAM_OFFICER_NAME: MILLER, RITA K

PROJECT_TERMS: Acute;Anaphase;Architecture;Automobile Driving;Binding;biophysical techniques;Cell division;Cells;Chromosome Segregation;Chromosomes;Congenital Abnormality;daughter cell;Decision Making;design;Event;Goals;grasp;In Vitro;in vivo;Inherited;innovation;Kinetochores;Knowledge;Malignant Neoplasms;Mammalian Cell;Mammalian Chromosomes;Mechanics;Microtubules;Mitosis;Modeling;Molecular;molecular scale;Needles;optogenetics;physical process;physical property;reconstitution;Role;Shapes;Signal Transduction;Stress;Structure;Testing;Therapeutic;Time;tool;Work

PROJECT_TITLE: Emergent mechanics of mammalian chromosome segregation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-Y(55)R]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Hematology;Infectious Diseases;Sepsis

ORG_CITY: COLUMBIA

ORG_NAME: ACEPRE, LLC

ORG_STATE: SC

PHR: Narrative. Sepsis results in massive loss of life and places a significant economic burden on society. There are no effective treatments available for bacterial sepsis. We propose to develop JX06, a selective macrophage PDHK1 inhibitor, as a novel therapy for bacterial sepsis by suppressing macrophage NLRP3 inflammasome activation and restoring macrophage metabolic health.

PI_NAMEs: ZHU, XUEWEI  (contact)

PROGRAM_OFFICER_NAME: MINNICOZZI, MICHAEL

PROJECT_TERMS: Acute;Adrenal Cortex Hormones;analog;anergy;Animal Model;Anti-Inflammatory Agents;Antibiotics;Attention;Attenuated;Back;Bacteremia;Biochemical;Biological Availability;Bone Marrow;Brain;cecal ligation puncture;Cell Death;Cells;Cultured Cells;Cyclic GMP;Data;Dendritic Cells;Development;Dichloroacetate;Disease;Dose;Drug Kinetics;Economic Burden;effective therapy;Effectiveness;efficacy evaluation;Energy Supply;Family suidae;Female;fighting;Formulation;Generations;Glycolysis;Health;Heart;Hepatocyte;Heterogeneity;Histologic;Human;Immune;Immune system;Immunocompetence;Immunosuppression;improved;In Vitro;in vivo;Inbreeding;individual patient;Inflammasome;Inflammation;Inflammatory;inhibitor;Interleukin-1 beta;Invaded;Investigational Drugs;Kidney;Life;Liver;Macrophage;male;manufacture;marenostrin;Measurement;Mediating;Metabolic;metabolic fitness;Microbe;Mitochondria;mitochondrial dysfunction;Modeling;Molecular;Mononuclear;mouse model;Mouse Strains;Mus;Nigericin;novel therapeutics;Organ;organ regeneration;Outcome;oxidative damage;Oxidative Phosphorylation;Oxidative Stress;Paralysed;pathogen;Pathway interactions;Pattern;PDH kinase;Phagocytes;Phase;phase 2 study;Plasma;Play;pre-clinical;Process;Production;Proteins;Pyruvate;Reactive Oxygen Species;receptor;Regimen;Resolution;Role;Safety;safety testing;secondary infection;Sepsis;septic patients;Shock;Small Business Technology Transfer Research;small molecule;Societies;Survival Rate;T-Lymphocyte;Testing;Therapeutic;Therapeutic Agents;Time;Toll-like receptors;Toxic effect;Toxicity Tests;Vascular Endothelial Cell

PROJECT_TITLE: Targeting macrophage maladaptation for bacterial sepsis treatment

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DCAI-D(10)]


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative Individuals with autism spectrum disorder (ASD) show decreased motivation to engage in social interactions that are less rewarding for them. Yet, the neural populations that mediate social reward and how activity is altered in these regions in models of ASD are not understood. Here, using new imaging tools, we will examine how the activity patterns of nucleus accumbens neurons and their inputs are altered in two models of ASD and whether real-time modulation of activity in these neurons can increase social interaction.

PI_NAMEs: GOLSHANI, PEYMAN  (contact);HONG, WEIZHE

PROGRAM_OFFICER_NAME: BREEDEN, ANDREW LEE

PROJECT_TERMS: Animals;autism spectrum disorder;Automobile Driving;Behavior;Behavioral;Biological Assay;Brain region;Calcium;cell type;Collaborations;Complement;Custom;Data;Development;Dopamine;Dopamine D2 Receptor;dopaminergic neuron;experimental study;Fiber;Frequencies;Functional disorder;Future;Genetic Models;Image;Imaging Device;Immediate-Early Genes;improved;Individual;individuals with autism spectrum disorder;Knowledge;Label;Learning;Medial;Mediating;Microscope;Microscopy;miniaturize;model of autism spectrum disorder;Modeling;Motivation;mutant;neural;neural circuit;Neurons;neuroregulation;Nucleus Accumbens;optogenetics;Pattern;Performance;Photometry;Play;Population;Population Analysis;Prefrontal Cortex;Probability;Productivity;Recording of previous events;Rewards;Role;Signal Transduction;social;Social Behavior;social contact;social deficits;Social Interaction;Task Performances;Testing;theories;Time;Ventral Tegmental Area

PROJECT_TITLE: Unstable nucleus accumbens social representations in models of social behavioral dysfunction.

STUDY_SECTION: PMDA

STUDY_SECTION_NAME: Pathophysiological Basis of Mental Disorders and Addictions Study Section[PMDA]


ORG_DEPT: ANATOMY/CELL BIOLOGY

PHR: Project Narrative: Establishing and maintaining cell polarity is essential for cell function and tissue integrity, whereas the disruption of cell polarity is often linked to tumorigenesis and injury under ischemia. In this proposal, we focus on a novel mechanism based on the newly discovered electrostatic interaction between polarity proteins and plasma membrane (PM) phosphoinositides. Electrostatic PM targeting acts as an integral mechanism that not only regulates the subcellular localization of polarity proteins, but also directly controls their polarity functions. Our research will facilitate the analysis and treatment of diseases such as ischemia and cancer by understanding how polarity may be established, maintained, and restored under normal and pathological conditions, including hypoxia, ischemia, and tumorigenesis.

PI_NAMEs: HONG, YANG  (contact)

PROGRAM_OFFICER_NAME: RIGAS, MARC

PROJECT_TERMS: Acute;Address;Allosteric Regulation;Apical;Automobile Driving;Back;Binding;Binding Proteins;Biological;Biological Assay;Brain Hypoxia-Ischemia;Cell membrane;Cell Physiology;Cell Polarity;cell type;Cells;Cues;Cytosol;Data;Disease;dlg protein;Electrostatics;Fluorescence Resonance Energy Transfer;Goals;Hypoxia;Injury;Ischemia;Knowledge;Link;Lipids;Malignant Neoplasms;Membrane;Molecular;Molecular Conformation;novel;Pathologic;Phosphatidylinositol 4,5-Diphosphate;Phosphatidylinositols;Phospholipids;Phosphorylation;Phosphotransferases;Physiological;Play;polarized cell;Predisposition;Process;protein complex;protein protein interaction;Proteins;Recovery;Regulation;Research;Role;sensor;spatiotemporal;Stress;System;Tissues;tumorigenesis

PROJECT_TITLE: Plasma Membrane Targeting and Retargeting of Polarity Proteins

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-H(80)S]


NIH_SPENDING_CATS: Autoimmune Disease;Genetics;Lupus

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE Systemic lupus erythematosus (SLE) is a chronic inflammatory disease with clear contribution of so-called Toll- like receptors (TLR); however, the mechanism how these receptors contribute to disease is incompletely understood. Based on detailed biochemical studies, we found a novel mechanism (pathway) how TLRs activate genes that are known to drive SLE. In this project, we will further study this pathway on a molecular level and establish its relevance for human SLE by using sophisticated novel mouse models, hopefully revealing a key mechanism that controls SLE as potential therapeutic target.

PI_NAMEs: HAECKER, HANS  (contact)

PROGRAM_OFFICER_NAME: RICE, JEFFREY S

PROJECT_TERMS: Adaptor Signaling Protein;Address;Amino Acids;B-Cell Antigen Receptor;Binding;Biochemical;Biological Assay;Biology;C-terminal;CBL gene;Cell Line;Cells;chronic inflammatory disease;Coupled;CRISPR/Cas technology;Disease;Equilibrium;Event;Family;gain of function;Gene Deletion;Gene Expression;Gene Expression Regulation;Genes;Genetic;Genetic Polymorphism;genetic regulatory protein;Goals;Heterozygote;Human;Immune;Immune response;Immunologic Receptors;In Vitro;in vitro Assay;in vivo;Inflammation;Inflammatory;Interferon Receptor;Interferons;IRF1 gene;Knock-in;Knock-in Mouse;Link;Lupus;lupus-like;LYN gene;Mass Spectrum Analysis;Mediating;Modeling;Modification;Molecular;Molecular Mechanisms of Action;mouse model;Mus;Mutant Strains Mice;Mutation;MyD88 protein;novel;Pathologic;Pathology;Pathway interactions;Phenotype;Phosphorylation;Phosphotransferases;Phosphotyrosine;Physiological;Point Mutation;Polyubiquitination;prevent;Process;protein-tyrosine kinase c-src;Proteins;receptor;recruit;Regulation;Resistance;Role;Signal Transduction;Site;src-Family Kinases;Surface;Systemic Lupus Erythematosus;T-Lymphocyte;Therapeutic;therapeutic target;Toll-Like Receptor Pathway;Toll-like receptors;transcription factor;Tyrosine;Tyrosine Phosphorylation;ubiquitin-protein ligase;Ubiquitination;Work

PROJECT_TITLE: A phospho-tyrosine-based signaling module controlling TLR-mediated inflammatory disease.

STUDY_SECTION: HAI

STUDY_SECTION_NAME: Hypersensitivity, Autoimmune, and Immune-mediated Diseases Study Section[HAI]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alcoholism, Alcohol Use and Health;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Digestive Diseases;Genetics;Neurodegenerative;Neurosciences;Substance Misuse

ORG_CITY: KANSAS CITY

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: Project Narrative Alcohol abuse and consumption are associated with cognitive impairments, and the development of dementia. Alcohol consumption impairs lysosomal and mitochondrial biogenesis results in insufficient autophagy, accumulation of damaged mitochondrial and tau protein aggregates, and promoting Alzheimer's disease (AD). Elucidating the molecular mechanisms of how activation of transcription factor EB improves lysosomal biogenesis and autophagy that are impaired by alcohol will help to develop novel therapeutic strategies for treating/preventing AD.

PI_NAMEs: DING, WEN-XING  (contact)

PROGRAM_OFFICER_NAME: LI, TONG

PROJECT_TERMS: Affect;age related;age related decline;Aging;aging brain;aging population;aging related;Agonist;Alcohol abuse;Alcohol consumption;Alcoholic Hepatitis;Alcoholic Pancreatitis;Alcohols;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease risk;American;Amyloid beta-Protein;Autophagocytosis;Autophagosome;Biogenesis;Biology;Brain;brain dysfunction;Brain Injuries;chronic alcohol ingestion;Data;Degradation Pathway;Dementia;Development;Diet;Digestion;drug candidate;drug development;Elderly;Event;experimental study;feeding;FRAP1 gene;Functional disorder;gain of function;Gene Expression;Genetic;Heart;high throughput screening;Hippocampus;Histopathology;Homeostasis;Human;Impaired cognition;Impairment;improved;Knock-in;Knockout Mice;Link;Liver;liver injury;loss of function;Lysosomes;Mediating;Memory;Memory Loss;misfolded protein;Mitochondria;mitochondrial dysfunction;Mitochondrial Proteins;Modeling;Molecular;Monitor;mouse model;Mus;Muscle;Neurons;neuroprotection;novel;novel therapeutic intervention;Nuclear;old mice;Organelles;Outcome;overexpression;Pancreas;Pathology;pharmacologic;Phosphorylation;PPAR gamma;preservation;prevent;Process;protein aggregation;Proteins;proteostasis;Recovery;Risk Factors;Role;Series;Stains;tau aggregation;tau Proteins;tau-1;Tauopathies;Testing;therapeutic target;transcription factor;Transcriptional Activation;Transgenic Mice;TSC1 gene;Work

PROJECT_TITLE: Mechanisms of Impaired Lysosomal Biogenesis and Autophagy in Alcohol-Associated Alzheimer's Disease


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Chronic Fatigue Syndrome (ME/CFS);Complementary and Integrative Health;Neurosciences;Substance Misuse

ORG_CITY: RESEARCH TRIANGLE PARK

ORG_NAME: RESEARCH TRIANGLE INSTITUTE

ORG_STATE: NC

PHR: Project Narrative ME/CFS is a debilitating and complex disorder that affects millions of people worldwide; however, the underlying mechanisms that trigger ME/CFS symptoms and their treatment remain unknown. To better understand the causes and discover better diagnostics and treatments to improve the health outcomes for individuals with ME/CFS, RTI’s DMCC will continue to support this Network by (1) offering expertise in patient- centered research, data processing, and analysis; (2) providing tools to foster communication and monitor study progress; and (3) expanding the capabilities and reach of our publicly available ME/CFS research tools.

PI_NAMEs: BROWN, LINDA MORRIS;CARNES, MEGAN  (contact)

PROGRAM_OFFICER_NAME: DALEY, WILLIAM PATRICK

PROJECT_TERMS: Advisory Committees;Advocacy;Affect;Applied Research;Area;Awareness;biobank;Biological Markers;Biological Process;career;CCR;Chronic Fatigue Syndrome;Classification;Clinical;Clinical Data;cloud based;Collaborations;Collection;Common Core;Common Data Element;Communication;Communications Media;Communities;Complex;computerized data processing;Coordination and Collaboration;dashboard;Data;Data Collection;Data Coordinating Center;data de-identification;data exploration;data hub;data integration;data mining;data portal;data quality;Data Set;data sharing;Data Sources;data tools;design;Diagnostic;Disease;Doctor of Philosophy;electronic data capture system;Electronic Mail;Ensure;Epidemiologist;Etiology;Event;experience;Facebook;FAIR principles;Fostering;Foundations;Future;Goals;Group Meetings;Growth;Health;improved;Individual;innovation;instrument;Interdisciplinary Study;Intervention Trial;Leadership;Longitudinal Studies;meetings;member;Modeling;Monitor;multiple omics;National Institute of Neurological Disorders and Stroke;Newsletter;novel;Observational Study;Online Systems;Outcome;Outcome Measure;outreach;Participant;Pathogenesis;patient oriented;Patients;Pattern;Persons;Pharmacogenetics;phenotypic data;Population;Positioning Attribute;Principal Investigator;Privatization;Procedures;Productivity;Publications;quality assurance;recruit;Research;Research Personnel;Resource Sharing;Resources;sample collection;Sampling;Science;Secure;sharing platform;Side;Site;social media;success;support network;symposium;Symptoms;System;Time;Time Study;tool;Training;Twitter;United States National Institutes of Health;Update;user-friendly;virtual;web platform;web site

PROJECT_TITLE: DMCC for ME/CFS CCR: Recompete 2022

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ICN-N(50)R]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Breast Cancer;Cancer;Childhood Leukemia;Genetics;Hematology;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases;Women's Health Research

ORG_CITY: WEST LAFAYETTE

ORG_DEPT: CHEMISTRY

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: Project Narrative: CDK12/13, CDK18 and FLT3, inhibitors will be developed. These anti- proliferative molecules will be developed into pre-clinical candidates for acute myeloid leukemia and breast cancer.

PI_NAMEs: KAPUR, REUBEN ;SINTIM, HERMAN O (contact)

PROGRAM_OFFICER_NAME: AGYIN, JOSEPH KOFI

PROJECT_TERMS: 70-kDa Ribosomal Protein S6 Kinases;Acute Myelocytic Leukemia;acute myeloid leukemia cell;ADME Study;Affect;Antineoplastic Agents;Aromatase Inhibitors;Attention;Autopsy;Binding;Binding Proteins;Biochemical;Biological Availability;biophysical properties;Brain;BRCA mutations;Breast;Breast Cancer cell line;Breast Cancer Patient;Caco-2 Cells;cancer cell;Cancer Model;Cancer Patient;cancer therapy;Caspase;CDC2 gene;CDK2 gene;CDK4 gene;Cell Cycle;Cell Cycle Progression;Cell Death;Cell Line;Cell Physiology;Cells;Chemistry;Clinic;Clinical;Clinical Trials;curative treatments;Cyclin-Dependent Kinase Inhibitor;Cyclin-Dependent Kinases;Cyclins;Cytochrome P450;Data;Development;DNA Damage;DNA Repair;Dose;Doxorubicin;Drug Kinetics;Drug resistance;Drug Targeting;efficacy study;Enzymes;Estrogen receptor positive;Estrogen Receptors;Evaluation;Excipients;Exclusion;experience;flasks;FLT3 gene;FLT3 inhibition;FLT3 inhibitor;FRAP1 gene;Fulvestrant;Generations;Genetic Transcription;Goals;Heart;Hematologic Neoplasms;Histology;Hormones;Hydrolase;In Vitro;in vivo;Indiana;inhibitor;Japan;kinase inhibitor;Lead;Letrozole;leukemia;Liver;Liver Microsomes;Lung;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Neoplasms;Maximum Tolerated Dose;Mediating;medical schools;Medicine;MEKs;Mus;mutant;Mutate;Mutation;nanomolar;novel;novel therapeutics;older patient;Oncogenic;Oncology;operation;Oral;Organ;Outcome;Pathologic;Pathway interactions;Patients;Pattern;Permeability;Pharmaceutical Preparations;pharmacologic;Pharmacologic Substance;Phase I/II Clinical Trial;Phase III Clinical Trials;Phosphorylation;Phosphotransferases;PI3K/AKT;Poly(ADP-ribose) Polymerase Inhibitor;pre-clinical;Property;protein kinase inhibitor;quinoline;refractory cancer;Relapse;Resistance;resistance mechanism;response;scaffold;scale up;Secondary to;Serum;Serum Proteins;Signal Pathway;Solid Neoplasm;Solubility;Specialist;Spleen;Survival Rate;synergism;Therapeutic;Time;Toxic effect;Transcriptional Regulation;Translations;triple-negative invasive breast carcinoma;Tumor Biology;tumor growth;Xenograft Model

PROJECT_TITLE: 3H-pyrazolo[4,3-f]quinoline-containing compounds as selective and tunable protein kinase inhibitors

STUDY_SECTION: DMP

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology Study Section[DMP]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: NEW YORK

ORG_DEPT: SURGERY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative The aim of this project is to investigate a role of cyclophilin D-mediated mitochondrial permeability transition pore (mPTP) in Tau pathology and mitochondrial stress, leading to neurodegeneration and cognitive decline relevant to the pathogenesis of Alzheimer's disease. The outcomes of the proposed studies would also support that CypD might be a potential new therapeutic agent for eliminating and limiting Tau pathology and Toxic tau species accumulation and restoring mitochondrial and synaptic function.

PI_NAMEs: YAN, SHIRLEY SHIDU (contact)

PROGRAM_OFFICER_NAME: YANG, AUSTIN JYAN-YU

PROJECT_TERMS: Affect;Age;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease therapeutic;Amyloid beta-Protein;Attenuated;Behavioral;Blood Platelets;Brain;Cell Death;Cell Line;Cell Membrane Permeability;Cerebrum;chemokine;Cognitive;cognitive function;cyclophilin D;cytokine;Cytoplasm;Data;Defect;Disease Progression;Environment;feasibility research;Functional disorder;Genetic;genetic manipulation;glial activation;Goals;Human;human model;Hybrids;hyperphosphorylated tau;Immune;Impaired cognition;In Vitro;in vivo;Inflammation;Inflammation Mediators;Inflammatory;Inflammatory Response;Injury;insight;Learning;Link;Maintenance;MAPT gene;Mediating;Memory impairment;Metabolism;Microglia;Mitochondria;Mitochondrial Diseases;Mitochondrial DNA;mitochondrial dysfunction;mitochondrial membrane;mitochondrial permeability transition pore;Modeling;Molecular;mouse model;Mus;Natural Immunity;Nerve Degeneration;neurofibrillary tangle formation;neuroinflammation;neuron loss;Neurons;new therapeutic target;novel;novel therapeutics;Outcome;Outcome Study;Pathogenesis;Pathologic;Pathology;Patients;Pattern;Pattern recognition receptor;Peptidylprolyl Isomerase;Phagocytosis;Play;postsynaptic;presynaptic;Production;Property;protective effect;receptor for advanced glycation endproducts;Research;Role;Signal Transduction;Stress;Synapses;synaptic function;synaptic pruning;Synaptic Transmission;Synaptosomes;tau aggregation;tau mutation;tau Proteins;tau-1;Tauopathies;Testing;Therapeutic Agents;TLR9 gene;Toxic effect;transcription factor;Transcriptional Activation

PROJECT_TITLE: Mitochondria modulate Tau pathology and neuroinflammation

STUDY_SECTION: CDIN

STUDY_SECTION_NAME: Chronic Dysfunction and Integrative Neurodegeneration Study Section[CDIN]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: IRVINE

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: PROJECT NARRATIVE This project will carry out basic research into the causes of Alzheimer disease (AD), specifically those forms of AD that are not attributable to specific genetic causes. We will use a novel animal model that expresses the human form of a protein known as the amyloid ß-protein (Aß), which is strongly implicated in the disease, to test the extent to which transient increases in the levels of Aß—either all forms of Aß or exclusively extracellular or intracellular forms—induced at different ages are sufficient to trigger AD-like pathology in old age. Because increases in Aß are a common consequence of several AD risk factors, this work is expected to improve our understanding of the origins of AD, and may lead to the development of innovative therapies and/or improved methods for the early detection of this devastating disease.

PI_NAMEs: LEISSRING, MALCOLM A (contact)

PROJECT_TERMS: ABCB1 gene;Abeta clearance;abeta deposition;Abeta synthesis;Address;Age;age related;Aging;Alzheimer like pathology;Alzheimer's Disease;Alzheimer's disease risk;Amyloid;Amyloid beta-Protein;amyloidogenesis;Animal Model;animal old age;Aspartic Endopeptidases;Basic Science;Blood - brain barrier anatomy;Brain;Cathepsins;Cells;Cerebrum;Chronic;Clinical;Clinical Trials;Data;Defect;Deposition;Development;Diffuse;Disease;DNA Sequence Alteration;Down-Regulation;Early Diagnosis;effective therapy;Elderly;empowerment;Environment;Etiology;experimental study;Exploratory/Developmental Grant for Diagnostic Cancer Imaging;extracellular;familial Alzheimer disease;Genetic;Goals;Grant;Human;human old age (65+);Impairment;improved;inhibitor;innovation;Innovative Therapy;insight;interest;Knock-in Mouse;late life;Lead;Life;Link;Memory Loss;Methods;Modeling;mouse model;Mus;Mutation;Neprilysin;Nerve Degeneration;Neuronal Dysfunction;Neurons;normal aging;novel;old mice;Pathogenesis;Pathologic;Pathology;Peptide Hydrolases;poor sleep;promoter;Proteins;Publishing;Risk Factors;Role;Senile Plaques;Stress;Study models;Symptoms;Tariquidar;Testing;therapeutically effective;Time;Traumatic Brain Injury;Twin Multiple Birth;Work

PROJECT_TITLE: Temporal and spatial aspects of amyloidogenesis in sporadic Alzheimer disease


NIH_SPENDING_CATS: Autoimmune Disease;Bioengineering;Clinical Research;Crohn's Disease;Digestive Diseases;Inflammatory Bowel Disease;Machine Learning and Artificial Intelligence;Microbiome;Nutrition;Precision Medicine;Prevention

PHR: Project Narrative Despite achieving remission, up to 30% of patients with Crohn’s disease (CD) or ulcerative colitis (UC) will relapse over the subsequent 3 years. The mechanisms of sustained remission have not been defined. We propose a targeted effort that comprehensively and longitudinally profiles a homogeneous cohort of patients in deep remission to define the dynamic perturbations resulting in the inception of inflammation in quiescent disease.

PI_NAMEs: ANANTHAKRISHNAN, ASHWIN N (contact);XAVIER, RAMNIK J

PROGRAM_OFFICER_NAME: PAWLIKOWSKA, LUDMILA SYLWIA

PROJECT_TERMS: Affect;Autoimmune Diseases;Bacteroides;Biological;Biological Markers;Biopsy;Blood specimen;Carnitine;Cells;Characteristics;Clinical;cohort;Colon;Complex;Consumption;Crohn's disease;Data;deep learning;deep learning algorithm;defined contribution;Development;Diet;Direct Costs;Disease;Disease remission;disorder prevention;Drug Kinetics;dysbiosis;Environment;Environmental Exposure;fecal metabolome;fecal microbiome;Feces;follow-up;Food;Future;Gene Expression Profile;Genes;Genetic Transcription;gut microbiome;Health;healthy volunteer;Immune;Individual;Inflammation;Inflammatory;Inflammatory Bowel Diseases;Influentials;insight;Institution;Intake;Interleukin-10;Intervention;Machine Learning;machine learning model;machine learning prediction;Maintenance;Measurement;Mediating;metabolome;metabolomics;Metagenomics;microbial;microbiome;Modeling;Molecular;Morbidity - disease rate;Mucous Membrane;Neural Network Simulation;novel therapeutics;outcome prediction;Pathogenesis;Pathway interactions;Patient Recruitments;Patients;Pharmaceutical Preparations;Physical activity;Pilot Projects;Prediction of Response to Therapy;predictive modeling;prevent;prospective;Proteome;Proteomics;recruit;Recurrent disease;recurrent neural network;Registries;Relapse;relapse prediction;relapse risk;Resolution;risk prediction;Role;Sampling;Serum;single-cell RNA sequencing;Smoking;soluble fiber;Sphingolipids;Stress;targeted treatment;Technology;therapeutic target;therapy development;therapy resistant;Time;Tissues;tool;Training;transcriptome;transcriptomics;treatment optimization;Ulcerative Colitis;United States;Up-Regulation;Work

PROJECT_TITLE: Determinants of inception of inflammation in inflammatory bowel diseases

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DNPD-A(01)]


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: MIAMI

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: FLORIDA INTERNATIONAL UNIVERSITY

ORG_STATE: FL

PHR: PROJECT NARRATIVE Florida International University will establish a new Training program in Environmental Neuroscience (TENS) to support high-quality training of pre- and post-doctoral students in the unique and emerging field on neuroscience related to the environmental determinants of both neurodevelopmental and neurodegenerative diseases. As an Institution serving Hispanic and Underrepresented Minority groups, with a proven record of recruiting, retaining and graduating students in STEM (Science, Technology, Engineering, and Mathematics), we will provide a fully inclusive environment for the students to develop innovative technical and professional skills to approach the increasing neurological impacts related to the environment, which is increasingly affecting underserved minorities.

PI_NAMEs: ALLEN, TIMOTHY ALEXANDER;LUCCHINI, ROBERTO G (contact);TIEU, KIM

PROGRAM_OFFICER_NAME: SHREFFLER, CAROL A

PROJECT_TERMS: Neurosciences;Training

PROJECT_TITLE: Training in Environmental Neuroscience

STUDY_SECTION: EHS

STUDY_SECTION_NAME: Environmental Health Sciences Review Committee[EHS(T)]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Immunization;Infectious Diseases;Microbiome;Vaccine Related

ORG_CITY: ALBUQUERQUE

ORG_NAME: UNIVERSITY OF NEW MEXICO

ORG_STATE: NM

PHR: Project Narrative/Relevance The relevance of the project to public health is that it deals with host immune responses and inflammation during Toxoplasma gondii infection. This parasite is classified as a class B biodefense pathogen that can cause life-threatening disease in immunocompromised populations and in congenital infection. The project may ultimately identify new targets to treat disease and to improve immunity to microbial infection.

PI_NAMEs: DENKERS, ERIC Y (contact)

PROGRAM_OFFICER_NAME: PESCE, JOHN T

PROJECT_TERMS: adaptive immunity;Animals;biodefense;Biological Response Modifiers;Cell Physiology;cell type;Cells;Cessation of life;chronic infection;Classification;congenital infection;cytokine;Cytokine Receptors;Disease;effector T cell;emerging pathogen;Epithelial Cells;Epithelium;Event;experimental study;Family;gastrointestinal epithelium;Gastrointestinal tract structure;Generations;gut microbiota;Health;Health Hazards;Helminths;Host Defense;Host Defense Mechanism;host microbiota;Human;human pathogen;Immune;Immune response;Immune system;Immunity;Immunocompromised Host;immunodeficiency;Immunologic Memory;improved;Infection;Infection Control;Inflammation;Innate Immune Response;insight;Interferons;Interleukin-1;Interleukin-12;intestinal epithelium;Intestinal Mucosa;Intestines;knockout animal;Knockout Mice;Lamina Propria;Lead;Life;long term memory;Lymphoid Cell;Memory;microbial;microbiota;Molecular;Motion;Mouse Strains;Mucosal Immune System;Mucosal Immunity;Mucous Membrane;Mus;Natural Immunity;novel;opportunistic pathogen;Oral;Organism;Organoids;Outcome;Parasites;pathogen;pathogenic microbe;Pathology;Pathway interactions;Pattern;Phenotype;Population;Production;profilin;Public Health;receptor;Receptor Signaling;Research;Research Personnel;Resistance;resistance mechanism;Resistance to infection;response;Role;Route;Series;Shapes;Signal Transduction;T memory cell;T-Lymphocyte;Toll-like receptor 11;Toll-like receptors;tool;Toxoplasma;Toxoplasma gondii;Toxoplasmosis;Vaccinated;Viral;Work

PROJECT_TITLE: Unravelling MyD88-dependent and independent mucosal immunity to Toxoplasma


PHR: Project Narrative Lung cancer is the leading global cause of cancer-related mortality. For patients with advanced lung cancer harboring ALK gene fusions (‘ALK+ lung cancer’), highly effective ALK inhibitors have improved their outcomes, and yet, acquired resistance to these drugs remains a major problem resulting in disease relapse and ultimately death. The goal of this research is to identify therapeutic strategies to overcome resistance to the current standard-of-care ALK inhibitors, in hopes to extend and improve lives of patients living with this disease.

PI_NAMEs: HATA, AARON N (contact);LIN, JESSICA JIYEONG

PROGRAM_OFFICER_NAME: FORRY, SUZANNE L

PROJECT_TERMS: Accounting;acquired drug resistance;Address;Adoptive Cell Transfers;ALK gene;Alleles;anaplastic lymphoma kinase;Automobile Driving;Biopsy;Bypass;Cancer Etiology;Cancer Patient;Cell Line;Cessation of life;Chimeric Proteins;Chromosomal Rearrangement;Clinic;Clinical;Clinical Trials;cohort;Collection;Combined Modality Therapy;crizotinib;Data;Development;Diagnosis;Disease;Drug resistance;Engineering;EP300 gene;Epigenetic Process;Epitopes;Foundations;Future;Gene Fusion;Gene Rearrangement;Generations;Genetic Transcription;Genomics;Goals;IL2-Inducible T-Cell Kinase;Immune;Immune checkpoint inhibitor;immunogenic;Immunotherapy;improved;In Vitro;in vivo;inhibitor;Institution;Institutional Review Boards;kinase inhibitor;Malignant neoplasm of lung;Maps;Mediating;Methods;MHC Class I Genes;molecular subtypes;mortality;Mutation;neoantigens;Neurons;New Agents;next generation;non-genomic;Non-Small-Cell Lung Carcinoma;Normal tissue morphology;novel;novel strategies;novel therapeutic intervention;Oncogenic;Outcome;Patients;Pattern;pharmacologic;Phosphotransferases;Pre-Clinical Model;programs;Protocols documentation;rational design;Receptor Activation;Receptor Protein-Tyrosine Kinases;Recurrence;Recurrent disease;Research;Research Personnel;Resistance;resistance mechanism;resistance mutation;Role;Sampling;Signal Pathway;Signal Transduction;Specimen;standard care;standard of care;T-Cell Receptor;T-Lymphocyte;Therapeutic;therapeutic target;therapy development;Tissues;Transcription Coactivator;tumor;Tumor Cell Line;Tyrosine Kinase Inhibitor;United States

PROJECT_TITLE: Overcoming Resistance Mechanisms to Anaplastic Lymphoma Kinase Inhibitors

STUDY_SECTION: MCTB

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics B Study Section[MCTB]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Orphan Drug;Osteoporosis;Rare Diseases

ORG_CITY: WASHINGTON

ORG_NAME: AMERICAN SOCIETY FOR BONE & MINERAL RES

ORG_STATE: DC

PHR: This application seeks funding for a three year R13 grant to advance the field of musculoskeletal diseases by focusing on three specific areas of scientific research: 1) “Rare Diseases: From Molecules and Mechanisms to Therapeutics”; 2) “Osteocytes in Bone Health and Disease and as Therapeutic Target Cells”; 3) “Energy Metabolism in Skeletal Development and Disease”. These three areas cover a range of topics that collectively contribute to major clinical morbidity, disability and mortality. The overall objective of this R13 is to stimulate further advances that will result in improved patient care for musculoskeletal diseases by bringing together the best researchers for each of the three symposia that will be held in conjunction with the Annual Meetings of the American Society for Bone and Mineral Research, the largest professional, scientific and medical society established to bring together clinical and laboratory-based scientists who are involved in the study of bone, mineral and musculoskeletal science.

PI_NAMEs: BELLIDO, TERESITA M. (contact);SCHIPANI, ERNESTINA ;TETI, ANNA MARIA

PROGRAM_OFFICER_NAME: CHEN, FAYE H

PROJECT_TERMS: Affect;American;Area;Award;Basic Science;Biological;Biology;bone;Bone Diseases;bone health;Cells;Clinic;Clinical;Clinical Research;Clinical Trials;Defect;Development;Diabetes Mellitus;Diné Nation;direct application;disability;Disease;drug discovery;drug repurposing;effective therapy;Endocrine;Energy Metabolism;Evolution;Functional disorder;Funding;Genes;Genetic;genetic technology;Goals;Grant;Health;Hormones;Hypoxia;Imaging technology;improved;innovation;interest;International;Knowledge;Laboratories;Malignant Neoplasms;Mediating;Medical Societies;meetings;men;Metabolic Diseases;Metabolism;Minerals;Mitochondria;Morbidity - disease rate;mortality;Musculoskeletal;Musculoskeletal Diseases;novel strategies;novel therapeutics;Organ;Osteocytes;Osteoporosis;Pathogenesis;Patient Care;Patients;posters;pre-clinical;preclinical development;prevent;Professional Organizations;programs;Rare Diseases;Recording of previous events;Research;Research Personnel;response;Role;Science;Scientific Societies;Scientist;Series;Signal Transduction;skeletal;Skeletal Development;skeletal disorder;Skeleton;Societies;State-of-the-Art Reviews;success;symposium;Syndrome;Therapeutic;therapeutic target;Therapeutic Uses;Translating;Translational Research;United States National Institutes of Health;Update;Woman

PROJECT_TITLE: ASBMR Three Year Pre-Meeting Symposia

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


NIH_SPENDING_CATS: Biotechnology;HIV/AIDS;Immunization;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE Stabilized HIV-1 envelope trimer vaccines such as BG505 SOSIP elicit strong neutralizing antibody responses that protect against the matched virus in nonhuman primates. Here, we will understand how these neutralizing antibodies are elicited and acquire breadth in some instances, and how this compares to humans immunized with same vaccine along with multiple adjuvants.

PI_NAMEs: DERDEYN, CYNTHIA ANN (contact)

PROGRAM_OFFICER_NAME: SINGH, ANJALI

PROJECT_TERMS: Address;Adjuvant;Alleles;Animals;Antibodies;Antibody Response;Antibody Specificity;Antibody titer measurement;antigen binding;Antigens;Attention;Autologous;B-Lymphocytes;Binding;Binding Sites;biophysical properties;Biophysics;CD4 Antigens;Characteristics;Clinical;clinically significant;Cryoelectron Microscopy;Cryopreservation;Cyclic GMP;Databases;Dependence;Development;Epitopes;Exhibits;Formulation;Germ Lines;glycosylation;HIV;HIV Envelope Protein gp120;HIV Vaccine Trials Network;HIV-1;Human;human subject;Human Volunteers;Immunization;Immunize;Immunoglobulin G;Immunoglobulins;improved;Individual;Macaca mulatta;Maps;Modeling;multidisciplinary;mutant;neutralizing antibody;neutralizing monoclonal antibodies;non-Native;nonhuman primate;novel;Participant;Pathway interactions;Phase I Clinical Trials;Plasma;Polysaccharides;pre-clinical;preclinical study;Production;Resources;Retrospective Studies;Sampling;Serum;simian human immunodeficiency virus;Site;Structure;Surface Plasmon Resonance;Testing;Vaccination;vaccination strategy;Vaccines;Variant;Viral;Virus;X-Ray Crystallography

PROJECT_TITLE: Tracking the evolutionary trajectory of neutralizing antibodies following BG505 SOSIP immunization

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIB-T(90)]


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Clinical Research;Genetics;Human Genome;Neurosciences;Pediatric;Rare Diseases

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: PROJECT NARRATIVE Pontocerebellar hypoplasia syndrome is a multigenic Mendelian neurodevelopmental disorder showing loss of subclasses of neurons within the hindbrain. We propose to identify the remaining disease genes and to test mechanisms of altered RNA splicing invoking genotoxic stress and apoptosis.

PI_NAMEs: GLEESON, JOSEPH G (contact)

PROGRAM_OFFICER_NAME: RIDDLE, ROBERT D

PROJECT_TERMS: Affect;age related;Apoptosis;Appearance;Attention;Award;Basal Ganglia;Brain;Brain Diseases;brain magnetic resonance imaging;Brain Stem;Candidate Disease Gene;Cell model;Cell Physiology;Cells;Cerebellum;Cerebral cortex;Childhood;Clinical;Clinical Trials;cohort;consanguineous family;Data;Databases;Defect;Deglutition;Development;Disease;disease mechanisms study;DNA;DNA Damage;Encephalopathies;Enrollment;exome sequencing;Eye Movements;Family;Funding;Future;gene discovery;Gene Mutation;Genes;Genetic;genome integrity;genome sequencing;Genomics;Genotoxic Stress;Genotype;Goals;hindbrain;Human;Impairment;in vitro testing;in vivo;in vivo Model;Individual;infancy;Inherited;insight;interest;Knock-in Mouse;knockout gene;Lead;Loss of Heterozygosity;Meiosis;Messenger RNA;Methods;Middle East;Modification;Molecular;Molecular Diagnosis;Mus;Mutate;Mutation;Nerve Degeneration;neural;neurodevelopment;Neurodevelopmental Disorder;Neurologic;neuron apoptosis;neuron loss;Neurons;novel;Nuclear;Nuclear Accidents;Organoids;overexpression;Paralysed;Pathogenicity;Pathway interactions;Patients;Perinatal;Phenotype;Pontine structure;Pontocerebellar hypoplasia;Protein Biosynthesis;Proteins;Psyche structure;Publishing;radiological imaging;recruit;Resources;response;Ribonuclease H;Risk;RNA;RNA Processing;RNA Splicing;Secure;Series;Small Nuclear RNA;Spinal Cord;Spliceosomes;Structure;Susceptibility Gene;Syndrome;Termination of pregnancy;Testing;TP53 gene;transcriptomics;Transfer RNA;Validation;Variant;ventilation;virulence gene;whole genome;Work

PROJECT_TITLE: Molecular Characterization of Pontocerebellar Hypoplasia

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


ORG_NAME: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR

PHR: PROJECT NARRATIVE  This is a renewal application for a successful training program supporting predoctoral and postdoctoral trainees in research on cardiovascular disease at the University of New Mexico Health Sciences Center. Cardiopulmonary diseases, including heart disease, stroke and chronic obstructive pulmonary disease, continue to be the leading causes of death in the U.S., and disproportionately affect medically underserved populations. This training program aims to prepare highly skilled scientists from diverse backgrounds underrepresented in the field of cardiovascular and pulmonary research to reduce the future health impact of these diseases.

PI_NAMEs: RESTA, THOMAS C (contact)

PROGRAM_OFFICER_NAME: LIDMAN, KARIN FREDRIKSSON

PROJECT_TERMS: Minority-Serving Institution;Research Training;Training Programs

PROJECT_TITLE: Minority Institutional Research Training Program (T32)


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Eye Disease and Disorders of Vision;Genetics;Human Genome;Macular Degeneration;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_DEPT: OPHTHALMOLOGY

PHR: Narrative: The goal of this proposal is to understand the molecular pathology of inherited retinal degeneration by generating maps of retinal cell type specific regulatory elements and identifying non-coding mutations involving these regulatory regions.

PI_NAMEs: AYYAGARI, RADHA  (contact);FRAZER, KELLY A

PROGRAM_OFFICER_NAME: COOK, TIFFANY

PROJECT_TERMS: Ablation;Affect;Animal Model;Architecture;base editing;Biological Assay;Blindness;candidate validation;causal variant;Cell Culture Techniques;Cell model;Cell Nucleus;cell type;Cells;Choroid;Chromatin;Code;Collaborations;Computer Analysis;CRISPR/Cas technology;Data;Data Set;Development;Disease;disease model;disease-causing mutation;DNA;DNA methylation profiling;Enhancers;Epigenetic Process;epigenomics;Female;Gene Mutation;Genes;Genetic;Genetic Models;genetic pedigree;Genome;genome sciences;genome sequencing;Goals;Human;Human Genome;human induced pluripotent stem cells;human tissue;improved;in vivo;Individual;Inherited;inherited retinal degeneration;innovation;insight;invention;Japan;Joints;Left;macula;male;Maps;Methodology;methylome;Modeling;Molecular;molecular pathology;mouse model;multidisciplinary;Multiomic Data;multiple omics;Mutation;Mutation Detection;Netherlands;novel therapeutics;Nucleic Acid Regulatory Sequences;Nucleotides;Outcome;Outcome Study;Pakistan;Pathologic;Pathology;patient derived induced pluripotent stem cells;Patients;Peripheral;Physiological;Positioning Attribute;Recording of previous events;Regulatory Element;Research;Research Personnel;Resolution;Resources;Retina;Retinal Degeneration;Retinal Diseases;Retinal Dystrophy;RNA;RNA Splicing;Sequence Analysis;single cell genomics;Site;stable cell line;Structure;Structure of retinal pigment epithelium;Switzerland;System;Testing;Time;Tissue Sample;Tissues;tool;Transcript;transcriptome;Untranslated RNA;Validation;Variant;whole genome

PROJECT_TITLE: Unraveling the molecular pathology of retinal degeneration through single cell genomics

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


NIH_SPENDING_CATS: Mental Health

PHR: PROJECT NARRATIVE This training program is motivated by the fact that mental disorders are among the leading causes of disability in the world, and improved strategies to reduce their burden are needed. The goal of this training program is to produce the next generation of psychiatric epidemiologists who can address this need by conducting research that will advance our understanding of the causes and consequences of mental disorders, and developing, implementing, and evaluating rationally designed interventions to prevent and/or control these disorders.

PI_NAMEs: VOLK, HEATHER E (contact);ZANDI, PETER P.

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TITLE: Psychiatric Epidemiology Training Program


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Health Services;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Neurosciences

ORG_CITY: LEBANON

ORG_NAME: DARTMOUTH-HITCHCOCK CLINIC

ORG_STATE: NH

PHR: LAY NARRATIVE Inconsistent and unpredictable treatment outcomes across individuals are reported in most neuropsychiatric conditions and highlight a major challenge in mental health care. We propose to use a measure of systems- level brain activity and machine learning to determine if information within brain activity could be used to implement individualized interventions in a pre-clinical model.

PI_NAMEs: DOUCETTE, WILDER T (contact)

PROGRAM_OFFICER_NAME: VAZIRI, SIAVASH

PROJECT_TERMS: Anterior;Attention deficit hyperactivity disorder;Behavior;Behavioral;Bilateral;Biological Markers;Biological Models;biomarker identification;Borderline Personality Disorder;Brain;Brain region;career;Clinical;Communication;Corpus striatum structure;Data;designer receptors exclusively activated by designer drugs;Diagnosis;discounting;effective therapy;Funding;Future;gene therapy;Genetic;Goals;Heterogeneity;Human;Impairment;implementation intervention;Individual;individual variation;individualized medicine;innovation;Intervention;Link;Machine Learning;machine learning model;Measures;Mediating;Mental disorders;Mental Health Services;Modeling;National Institute of Mental Health;neural;Neurobiology;neuropsychiatry;Nucleus Accumbens;Outcome;Pathway interactions;Patients;Performance;Pharmaceutical Preparations;pharmacologic;Physiology;Pre-Clinical Model;Predisposition;Rat Strains;Rattus;Reporting;Research Personnel;Rewards;Risk;risk sharing;Ritalin;Rodent;Rodent Model;Schizophrenia;sex;substance use;Suicide;System;Task Performances;Testing;theories;Therapeutic;Time;Training;translational goal;translational research program;Treatment outcome;Variant;Violence;Work

PROJECT_TITLE: Evaluating the potential of neural oscillation biomarkers in a rodent model of intervention outcome variation: Toward personalized mental health care