NIH_SPENDING_CATS: Clinical Research;Genetics;Human Genome;Immunotherapy;Infectious Diseases;Pediatric;Vector-Borne Diseases

ORG_CITY: BALTIMORE

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: PROJECT NARRATIVE Neonates and infants are highly susceptible to infections, particularly those caused by intracellular pathogens, because their protective CD4 T helper 1 responses have not reached adult levels. A subset of Innate-like T cells, unlike conventional CD4 T cells, are poised for rapid Th1 responses in early life, and may have protective roles against intracellular pathogens, but our understanding of their function in infants is limited. We propose an approach based on the analysis of transcriptional and chromatin accessibility profiles in the cord blood innate- like cells to study their function, with the long-term goal of learning how to harness their potential to improve infant responses to vaccines.

PI_NAMEs: CAIRO, CRISTIANA  (contact)

PROGRAM_OFFICER_NAME: PRABHUDAS, MERCY R

PROJECT_TERMS: 5 year old;Address;Adult;Africa;Africa South of the Sahara;Animal Model;Antigens;antimicrobial;ATAC-seq;Bacteria;Baltimore;BCG Live;Biological Assay;Biological Markers;Biological Models;Biology;Birth;Blood specimen;CD4 Positive T Lymphocytes;Cell Differentiation process;Cell Physiology;Cell Separation;Cell surface;Cells;Cellular biology;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Child;cholesterol biosynthesis;Chromatin;Clinical;Consensus;cost;cytokine;cytotoxic;Data Analyses;Data Set;Decidua Basalis;Effectiveness;Exposure to;fighting;Flow Cytometry;Foundations;Funding;Future;Gene Expression Profile;Genes;Genetic Transcription;Goals;Heterogeneity;high risk;Human;Human Genetics;IL18 gene;Immune;Immune response;Immune system;Immunity;Immunocompetence;Immunologics;improved;In Vitro;infancy;Infant;infant infection;Infection;Infectious Agent;Interleukin-15;Knowledge;Learning;Life;Lymphocyte;Malaria;Malawi;Maps;Maryland;Medicine;microbial;microorganism;Molecular;mortality;Mus;Mycobacterium tuberculosis;Myeloid Cells;NCAM1 gene;Neonatal;neonatal human;neonate;Outcome;pathogen;perforin;placental malaria;Plasmodium falciparum;Population;Predisposition;prenatal exposure;Process;programmed cell death protein 1;Proliferating;Protozoa;receptor;Research;Resources;response;Risk;RNA Sequence Analysis;Role;Sampling;single cell analysis;Sorting;Surface;T cell differentiation;T-Lymphocyte;Techniques;Testing;transcription factor;transcriptome;transcriptome sequencing;Umbilical Cord Blood;United States National Institutes of Health;vaccine response;Vaccines;Variant;Virus;XCL1 gene

PROJECT_TITLE: Analysis of cord blood Vd2 T cell differentiation and function using CITE-seq and ATAC-seq

STUDY_SECTION: IHD

STUDY_SECTION_NAME: Immunity and Host Defense Study Section[IHD]


ADMINISTERING_IC: CA

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Breast Cancer;Cancer;Immunotherapy;Nutrition;Physical Activity;Prevention;Women's Health Research

ORG_CITY: BUFFALO

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: ROSWELL PARK CANCER INSTITUTE CORP

ORG_STATE: NY

PHR: In the short term, this work will provide new knowledge showing that healthy lifestyle adherence improves BC outcomes through enhanced anti-tumor immunity (increased infiltration of activated CD8+ T cells). In the long term, this work has the potential to uncover novel, clinically significant immunologic insights revealing that lifestyle intervention could be used as a non-invasive clinical strategy, especially in the context of boosting the efficacy of immunotherapy and other standard or novel therapies by way of shifting a cold tumor hot. Wherein the immune system is a major player in treatment response and efficacy, such developments would be especially impactful for populations who are disproportionately diagnosed with aggressive tumors (i.e., TNBC) that are less responsive to current treatments, including immunotherapy.

PI_NAMEs: CANNIOTO, RIKKI  (contact)

PROGRAM_OFFICER_NAME: GALLICCHIO, LISA M

PROJECT_TERMS: Address;Adherence;Aftercare;aggressive breast cancer;Alcohol consumption;American;American Cancer Society;anti-cancer research;biobank;Biological;Breast Cancer Model;Breast Cancer Patient;breast cancer survival;cancer diagnosis;cancer prevention;Cancer Prognosis;cancer recurrence;cancer subtypes;cancer survival;CD8-Positive T-Lymphocytes;Cell Density;Cells;Cessation of life;Clinical;clinically significant;Data;data repository;design;Development;Diagnosis;Diet;Eating;effector T cell;Epidemiology;Exercise;exhaust;experience;fruits and vegetables;Guidelines;Health;healthy lifestyle;healthy weight;High Fat Diet;high risk;Immune;Immune system;Immunity;immunohistochemical markers;Immunologic Markers;Immunologics;Immunotherapy;improved;indexing;Infiltration;insight;Investigation;Knowledge;Life Style;lifestyle data;lifestyle factors;lifestyle intervention;Link;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Neoplasms;Mediating;Mediation;mortality;novel;novel therapeutics;Obesity;Outcome;participant enrollment;Pathway Analysis;Patients;peripheral blood;Phenotype;Physical activity;Population;pre-clinical;Preparation;prevent;Processed Meats;Publishing;Recommendation;Recurrence;Reporting;Research;Role;Running;Site;Smoking;spatial relationship;Stains;standard of care;sugar;Suggestion;sweetened beverage;Testing;Therapeutic;trafficking;Treatment Efficacy;treatment response;triple-negative invasive breast carcinoma;tumor;tumor growth;Tumor Immunity;tumor progression;Tumor Suppression;Tumor Tissue;tumor-immune system interactions;Woman;Work

PROJECT_TITLE: Linking lifestyles with tumor immune profiles to identify strategies for improving breast cancer outcomes

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-A (J1)]


ED_INST_TYPE: SCHOOLS OF MEDICINE

ORG_CITY: ANN ARBOR

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE There is an urgent unmet need to understand the liposarcoma tumor microenvironment to enable the discovery of new and efficacious immunotherapeutics for sarcoma patients. We will validate a spontaneous liposarcoma mouse model and characterize the intratumoral and systemic immune responses (Aim 1) and generate a Cre- inducible MDM2-overexpressing mouse needed to model the most common oncogenic drivers reported in human liposarcoma (Aim2).

PI_NAMEs: ANGELES, CHRISTINA VADALA (contact)

PROGRAM_OFFICER_NAME: SALOMON, RACHELLE

PROJECT_TERMS: anti-tumor immune response;Autologous;B-Lymphocytes;Biology;Blood;C57BL/6 Mouse;Cell Line;chemotherapy;Clinical Treatment;Clinical Trials;Communities;Complex;Dedifferentiated Liposarcomas;Development;Disease;Double Minutes;effective therapy;Evolution;Excision;Genetic;Genetically Engineered Mouse;Genomics;Growth;high risk;Histologic;Histology;Human;human data;Immune;Immune checkpoint inhibitor;Immune response;Immunity;Immunocompetent;Immunotherapeutic agent;Immunotherapy;improved;in vivo;Incidence;inducible Cre;inhibitor;innovation;insight;Kinetics;Lead;liposarcoma;lymphoid neoplasm;Malignant Neoplasms;Measures;Modeling;Molecular;mouse model;Mus;Mutation;neoplastic cell;novel;Oncogenic;Operative Surgical Procedures;overexpression;Patients;PD-1 inhibitors;Penetrance;phase II trial;Pilot Projects;Play;Population;Pre-Clinical Model;preclinical study;Preclinical Testing;programmed cell death protein 1;Progression-Free Survivals;Proteins;PTEN gene;Recurrence;Reporting;Research;response;Role;Sarcoma;Soft tissue sarcoma;Solid Neoplasm;Stomas;T memory cell;T-Lymphocyte;T-Lymphocyte Subsets;Tamoxifen;tertiary lymphoid organ;Testing;tissue resident memory T cell;Tissues;TP53 gene;Transgenic Mice;tumor;Tumor Immunity;tumor microenvironment;tumor-immune system interactions;Validation;Work

PROJECT_TITLE: Genetically engineered mouse models to investigate the liposarcoma microenvironment

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-P (J2)]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Aging;Atherosclerosis;Cardiovascular;Clinical Research;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Human Genome;Prevention

ORG_CITY: MILWAUKEE

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: Our current understanding of how blockages in human coronary arteries become unstable is incomplete, and our ability to predict future heart attacks in patients who have had blockages treated with stents and balloons is limited. We have developed a novel way to determine the genes expressed in human coronary plaques by obtaining the genetic material from balloons used when blockages are opened. These data will provide a deeper understanding of human coronary atherosclerosis, show important biological differences between stable and unstable plaques, identify potential therapeutic targets, and establish a new tool to predict the future risk of heart attacks in patients.

PI_NAMEs: LIANG, MINGYU ;WIDLANSKY, MICHAEL E (contact)

PROGRAM_OFFICER_NAME: SCHOPFER, DAVID WESLEY

PROJECT_TERMS: Acute;acute coronary syndrome;Address;Adult;Animal Model;Animals;Aorta;Arterial Fatty Streak;atherogenesis;Atherosclerosis;Automobile Driving;Autopsy;Beds;Biological;Biological Markers;Biological Process;Biology;Blood flow;Cadaver;cardiovascular risk factor;Cardiovascular system;Caring;Carotid Stenosis;Catheterization;Cause of Death;cDNA Library;Cells;Cessation of life;Clinical;clinical application;Clinical Data;Clinical Trials;Collection;Complication;Coronary;Coronary Arteriosclerosis;Coronary artery;Coronary heart disease;coronary plaque;cost;Dangerousness;Data;design;Development;Endothelial Cells;Ethnic Origin;Event;Femur;follow-up;Functional disorder;Future;Gene Expression;Gene Expression Profile;Genes;Genetic;Genetic Materials;Heart;Human;indexing;Individual;Infrastructure;insight;Knowledge;Life;Longterm Follow-up;men;Methods;Modeling;Modification;Molecular;Morbidity - disease rate;Morphology;mortality;mortality risk;Mus;Myocardial Infarction;Nature;new therapeutic target;novel;novel strategies;Pathogenesis;Patient Care;patient prognosis;Patients;Pattern;percutaneous coronary intervention;Peripheral;Peripheral arterial disease;Phenotype;Physiological;Pilot Projects;Population;predictive tools;Predictive Value;Procedures;Process;prognostic;prognostication;Proxy;racial diversity;recruit;Recurrence;Regulatory Pathway;Research;revascularization;Risk;Risk Assessment;risk prediction;risk stratification;RNA;Role;sample collection;Sampling;sex;sex as a biological variable;Solid;Stents;therapeutic target;tool;transcriptome;transcriptome sequencing;translational potential;United States National Institutes of Health;Variant;vascular bed;virtual;Woman;women versus men

PROJECT_TITLE: Human Coronary Artery Plaque Transcriptomes and Cardiovascular Risk Assessment

STUDY_SECTION: CCHS

STUDY_SECTION_NAME: Clinical Integrative Cardiovascular and Hematological Sciences Study Section[CCHS]


ADMINISTERING_IC: NS

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Bioengineering;Brain Disorders;Clinical Research;Neurosciences;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury;Women's Health Research

ORG_CITY: WORCESTER

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: WORCESTER POLYTECHNIC INSTITUTE

ORG_STATE: MA

PHR: PROJECT NARRATIVE Sex differences in concussion is important but little studied. We propose to develop subject-specific multiscale computational models to study the biomechanical basis of sex differences in concussion and subconcussion. We will characterize sex differences and validate the approach with a range of biomarkers using data from male and female athletes participating in contact sports and noncontact controls.

PI_NAMEs: JI, SONGBAI  (contact)

PROGRAM_OFFICER_NAME: UMOH, NSINI ALEASE

PROJECT_TERMS: Area;Attention;Axon;axon injury;Biological Markers;biological sex;Biomechanics;Blood;Brain;Brain Concussion;Brain Injuries;brain morphology;Brain region;British Columbia;Caring;Cerebrovascular system;chronic traumatic encephalopathy;Clinical;Complex;Computer Models;concussive symptom;contact sports;Corpus Callosum;Craniocerebral Trauma;Data;deep learning;Defect;design;Development;Disease;Elements;Exclusion;experience;Female;Future;Geometry;Head;head impact;Health Policy;healthcare burden;Heterogeneity;high risk;Hour;Human;Ice Hockey;improved;Individual;Injury;Investigation;kinematics;Knowledge;Length;male;Microtubules;mild traumatic brain injury;Modeling;models and simulation;Morphology;multi-scale modeling;Myelin Sheath;Nature;Neurocognition;neuroimaging;Organ;Outcome;Pathway interactions;Persons;Play;Policies;Policy Making;predictive modeling;Property;prospective;Public Health;Recording of previous events;Recovery;Recurrence;Reporting;Research;Resolution;response;Risk;Risk Factors;Seasons;Severities;sex;Sex Differences;sex linked trait;simulation;sociodemographic variables;Sports;subconcussion;Symptoms;Time;tractography;Traumatic Brain Injury;Universities;virtual;Weight-Bearing state;white matter;Work

PROJECT_TITLE: Biomechanical Basis of Sex Differences in Concussion and Subconcussion

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Aging;Cancer;Palliative Care

PHR: There are few training programs devoted to training of PhD nurse-scientists in cancer research so that they may develop independent research careers. This is a critical gap since nurse-scientists are in the best position to perform research focused on patients, families, and communities and translate this knowledge into improved cancer delivery and care. Importantly, while the emerging field of “symptom science” has been driven by nurse-scientists, there are remarkably few opportunities for them to acquire the oncology background needed for other areas of cancer research. This new K12 proposal addresses this gap while also aiming to increase representation of nurse-scientists from underrepresented backgrounds into the ranks of cancer researchers.

PI_NAMEs: DICKERSON, SUZANNE S.;REPASKY, ELIZABETH A (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: Academia;Address;Advanced Malignant Neoplasm;anti-cancer research;Biological;care coordination;care delivery;career;career development;chemotherapy;Clinical Oncology;clinical practice;Clinical Research;Clinical Trials;Competence;Comprehensive Cancer Center;Data;design;Discipline of Nursing;Doctor of Philosophy;Educational Status;Enrollment;experience;Faculty;Family;Funding;Future;Generations;Grant;Health Personnel;improved;innovation;insight;Lead;Malignant Neoplasms;Mentored Clinical Scientist Development Program;Mentorship;Monitor;Nurses;Oncology;Oncology Nurse;Patient Care;patient oriented research;Patient-Focused Outcomes;Patients;Personal Satisfaction;Postdoctoral Fellow;programs;Reporter;Research;Research Personnel;Research Training;Role;School Nursing;Scientist;skills;success;symptom management;symptom science;Time;Training;training opportunity;Training Programs;Translational Research;treatment response;United States National Institutes of Health;Universities;Walking

PROJECT_TITLE: Preparing Nurse Scientists to Lead the Future of Oncology Research

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


ORG_DEPT: ANESTHESIOLOGY

PHR: PROJECT NARRATIVE Our work is designed to eventually result in a chronic pain treatment that is highly effective, safe, flexible (applicable in many settings, and targeting peripheral nerve sodium channels), having minimal side effects and little to no abuse/addiction liability, and low-cost, since a single vector injection has lasting genetic efficacy.

PI_NAMEs: YU, HONGWEI  (contact)

PROGRAM_OFFICER_NAME: MOHAPATRA, DURGA PRASANNA

PROJECT_TERMS: Absence of pain sensation;Action Potentials;addiction liability;Afferent Neurons;Amino Acid Sequence;Amino Acids;Analgesics;Animal Behavior;Ankyrins;Area;Axon;Behavior;Behavioral;Binding;Biological;Cell Line;Cells;chronic pain management;comparison control;cost;Coupled;Data;density;design;Development;Disease;Experimental Designs;flexibility;Future;Genetic;Goals;Image Analysis;Immunohistochemistry;In Vitro;in vivo;Injections;innovation;Investigation;Ion Channel;Lead;Location;Mediating;Membrane;Names;Neurites;neuronal excitability;Neurons;neurotoxicity;new therapeutic target;Pain;pain inhibition;pain signal;Pathogenesis;Pathologic;Peptide aptamers;Peptides;Peripheral Nerves;Plasmids;Potassium Channel;Protein Binding Domain;Proteins;Rattus;Research;Role;Safety;Sensory;side effect;Signal Transduction;Site;Site-Directed Mutagenesis;Sodium;Sodium Channel;sodium channel proteins;Specificity;Tertiary Protein Structure;Testing;Toxic effect;trafficking;Transfection;Validation;vector;voltage clamp;Work

PROJECT_TITLE: Mechanism of dual Nav1.7 and Nav1.8 block by a NaV inhibitory peptide

STUDY_SECTION: NC

STUDY_SECTION_NAME: Neuronal Communications Study Section[NC]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cocaine;Drug Abuse (NIDA only);Genetics;Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: BOSTON

ORG_DEPT: GENETICS

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: Lay narrative (3 sentences) The potential impact of the proposed research includes discovery of key brain circuits, specialized neurons, and signaling pathways that regulate cocaine addiction-related behavior in mice, and by extension possibly in people. Unprecedented resolution in cell, circuit, and signal identification is expected through the innovative use of cutting-edge molecular genetic and electrophysiological approaches in model systems. Expected research outcomes of significance to public health include discovery of substrates that might inform therapeutic leads in the prevention and treatment of substance use disorders including the pivotal phase of relapse.

PI_NAMEs: DYMECKI, SUSAN M. (contact)

PROGRAM_OFFICER_NAME: NAIR, SUNILA GOPI

PROJECT_TERMS: Abstinence;Anatomy;aspirate;Axon;Behavior;Behavioral;biocytin;Biological Models;Brain;brain cell;Brain region;calbindin;Cell Nucleus;cell type;Cells;Cocaine;Cocaine Dependence;cocaine seeking;cocaine use;conditioned place preference;conditioning;Dendrites;density;Development;Distal;Drug Controls;drug reward;drug seeking behavior;Electrophysiology (science);Engineering;Extinction;Fiber;gamma-Aminobutyric Acid;Gene Expression;Genetic;genetic approach;Glutamates;Grant;Hippocampus;Human;Hypothalamic structure;In Situ Hybridization;Incentives;innovation;Lateral;Link;Maps;Medial;Memory;mesolimbic system;Messenger RNA;Methods;Molecular;Molecular Genetics;Morphology;Motivation;mRNA Expression;Mus;Names;neural;neurochemistry;neuronal cell body;Neurons;neurotransmission;Neurotransmitters;novel;optogenetics;Outcomes Research;Output;patch clamp;Pathway interactions;Persons;Pharmaceutical Preparations;Pharmacology;Phase;Phenotype;Play;postsynaptic;pre-clinical;preclinical study;Prefrontal Cortex;Preparation;presynaptic;Presynaptic Terminals;Prevention;Process;Property;Proxy;Psychological reinforcement;Public Health;receptor;Receptor Signaling;recombinase;Recovery;Relapse;Research;Resolution;response;Retrieval;Rewards;Role;septohippocampal;Serotonin;serotonin receptor;Shapes;Signal Pathway;Signal Transduction;Signaling Protein;SLC17A8 gene;Slice;Stimulus;Structure;Substance of Abuse;Substance Use Disorder;substance use treatment;Therapeutic;tool;transcriptome;transcriptome sequencing;transcriptomics;transmission process;Viral;With laterality;Work

PROJECT_TITLE: Control of drug-reward behavior and relapse vulnerability via a specialized serotonergic-septohippocampal circuit

STUDY_SECTION: MCNP

STUDY_SECTION_NAME:
Molecular and Cellular Neuropharmacology Study Section
[MCNP]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Contraception/Reproduction;Dementia;Hematology;Infectious Diseases;Neurodegenerative;Neurosciences;Sepsis

ORG_CITY: GAINESVILLE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE  Aged individuals are more prone to develop long-term cognitive impairment as a result of sepsis, and peripheral immune cell infiltration resulting from blood brain barrier alterations during the acute severe infection phase is emerging as a key mechanism linked to cognitive impairment and increased dementia risk associated with these infections. We have identified that the LHCGR ligand, hCG, has powerful neuroimmune regulating capabilities and improves cognition in impaired rodent models. Therefore, we seek to address the therapeutic value of hCG on sepsis-induced cognitive dysfunction and evaluate the neuroinflammatory mechanisms underlying such effects in the aged brain.

PI_NAMEs: CASADESUS, GEMMA  (contact)

PROGRAM_OFFICER_NAME: HAAKENSON, CHELSEA MARIE

PROJECT_TERMS: Acute;acute infection;Address;Age;age effect;aging brain;aging population;Agonist;Alzheimer's disease model;Alzheimer's disease related dementia;Alzheimer's disease risk;Anatomy;Animals;antagonist;Anti-Inflammatory Agents;Antiinflammatory Effect;Biological Response Modifiers;Blood - brain barrier anatomy;Blood brain barrier dysfunction;Brain;cecal ligation puncture;cell type;Cells;Central Nervous System;central nervous system injury;chemokine receptor;Chorionic Gonadotropin;Chronic;clinically relevant;Cognition;Cognitive;cognitive function;cognitive testing;Data;Dementia;dementia risk;Development;Diffuse;Disease;Economics;effective therapy;Environment;Evaluation;Event;excitatory neuron;Family;Flow Cytometry;functional improvement;Gene Expression;Genes;Hippocampus;Hormones;Human;Human Chorionic Gonadotropin;Image Analysis;Immune;immune cell infiltrate;Impaired cognition;Impairment;improved;Incidence;Individual;Infection;Infiltration;Inflammation;Inflammatory;Inflammatory Infiltrate;inflammatory marker;Inflammatory Response;Injury;Investigation;knock-down;Knowledge;Leucocytic infiltrate;LH Receptors;Ligands;Link;long-term sequelae;Luteinizing Hormone;Measures;Mediating;menopausal aging;Microglia;middle age;migration;Modeling;Molecular Conformation;monocyte;Morphology;Motor Activity;mouse model;Mus;Myeloid Cells;natural Blastocyst Implantation;Nervous System Disorder;Nervous System Physiology;Neurocognitive Deficit;Neurodegenerative Disorders;Neuroimmune;neuroinflammation;Neurologic;Neurologic Dysfunctions;Neuronal Plasticity;neuroprotection;neutrophil;novel;old mice;Older Population;Organ;Outcome;Pathogenesis;Pathologic;Pathology;Patients;Peripheral;Phase;Phenotype;Population;pre-clinical;Pregnancy;Pregnancy Maintenance;prevent;Property;Proteins;receptor;receptor expression;Regulation;Reporter;Reporting;reproductive;Resolution;Risk;RNA;Rodent;Rodent Model;Role;Saline;Secondary to;Sepsis;septic;septic patients;sex;Specificity;standard care;Stress;Stroke;Testing;Therapeutic;therapeutically effective;Time;TLR4 gene;trafficking;transcriptome sequencing;translational potential;Weight

PROJECT_TITLE: Evaluation of Chorionic Gonadotropin as a Treatment for Sepsis-induced Neuroinflammation and Cognitive Dysfunction in the Aged Brain

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Clinical Research;Dental, Oral, and Craniofacial Disease;Hematology;Infectious Diseases;Microbiome;Prevention;Sepsis

ORG_CITY: NEW YORK

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: PROJECT NARRATIVE Viridans group streptococci are bacteria that commonly cause life-threatening bloodstream infections in patients with hematologic cancers who have few white blood cells because of chemotherapy. These bacteria are often resistant to fluoroquinolone antibiotics used to prevent infections in these patients. The proposed research is relevant to public health and NIH’s mission because understanding how often patients with hematologic cancers carry fluoroquinolone-resistant viridans group streptococci in their mouth, how to best screen for carriage of these bacteria and how mouth carriage increases the risk of bloodstream infection, could lead to the design of novel individualized strategies to prevent these infections in this vulnerable patient population.

PI_NAMEs: SATLIN, MICHAEL JOSEPH (contact)

PROGRAM_OFFICER_NAME: GU, XIN-XING

PROJECT_TERMS: 16S ribosomal RNA sequencing;Acute Lung Injury;Agar;anti-microbial drug;Anti-microbial susceptibility;Antibiotics;Anus;Bacteremia;Bacteria;Bacterial Infections;Blood Circulation;breakthrough infection;Cessation of life;Characteristics;chemotherapy;Chlorhexidine;Clinical;clinically significant;cohort;design;Enrollment;Etiology;fluoroquinolone resistance;Fluoroquinolones;Goals;gut bacteria;gut colonization;Hematologic Neoplasms;Hematopoietic Stem Cell Transplantation;high risk;Incidence;Infection;Infection prevention;innovation;Intervention;Leukocytes;Levaquin;Life;Methods;microbial;Mission;Morbidity - disease rate;mortality;Multicenter Studies;Neutropenia;novel;novel strategies;Oral;oral bacteria;Oral cavity;oral microbiome;oral mucositis;Organism;Oropharyngeal;Participant;patient population;patient screening;Patients;personalized approach;personalized strategies;Prevalence;prevent;Prevention strategy;prophylactic;Prophylactic treatment;prospective;Public Health;Recommendation;Recovery;Research;Resistance profile;Risk;Risk Factors;Risk Reduction;screening;Sepsis;Septic Shock;Site;Specimen;standard of care;Streptococcal Infections;Streptococcus mitis;Streptococcus Viridans Group;Swab;Testing;Transplant Recipients;Transplantation;United States National Institutes of Health;Work

PROJECT_TITLE: Screening for Fluoroquinolone-Resistant Viridans Group Streptococci to Individualize Infection Prevention Strategies in Neutropenic Patients

STUDY_SECTION: EDIT

STUDY_SECTION_NAME: Etiology, Diagnostic, Intervention and Treatment of Infectious Diseases Study Section[EDIT]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Brain Disorders;Contraception/Reproduction;Estrogen;Mental Health;Neurosciences;Pediatric;Women's Health Research

ORG_CITY: EAST LANSING

ORG_DEPT: NEUROSCIENCES

ORG_NAME: MICHIGAN STATE UNIVERSITY

PHR: Narrative This research will investigate the role of gonadal hormones (estrogen in females, testosterone in males) in programming adolescent development of the mesocorticolimbic dopamine circuit, which is functionally linked to motivation, reward, and cognitive control. Studies will reveal how hormones influence typical maturation and within what developmental window(s) these influences can occur, and how typical maturation can go awry (e.g., atypical timing of puberty onset). Knowing how typical maturation can go awry will provide novel insights into the developmental processes during puberty and adolescence that could lead to the emergence of psychopathology marked by deficits in cognitive control.

PI_NAMEs: JOHNSON, ALEXANDER W.;SISK, CHERYL L. (contact)

PROGRAM_OFFICER_NAME: TONELLI, LEONARDO HERALDO

PROJECT_TERMS: Adaptive Behaviors;Adolescence;Adolescent;Adolescent Development;Adult;Axon;Brain;Cell Death;Cells;cognitive control;critical period;Development;developmental plasticity;Developmental Process;Dopamine;dopamine system;Estrogens;experience;Female;Gonadal Hormones;Gonadal Steroid Hormones;Growth;Hormonal;Hormone secretion;Hormones;Human;Impairment;innovation;insight;Investigation;Link;Location;male;Medial;Mediating;Mental Health;Motivation;nerve supply;Nervous System;neurodevelopment;Neurons;novel;Nucleus Accumbens;Prefrontal Cortex;prepuberty;Process;Program Development;programs;Psychopathology;psychosocial;pubertal timing;Puberty;Rattus;Research;Rewards;Risk;Risk Factors;Role;sex;Sex Differences;Synapses;synaptogenesis;System;Techniques;Testing;Testosterone;Varicosity;Ventral Tegmental Area;Viral;Visualization

PROJECT_TITLE: Hormonal Programming of the Mesocorticolimbic Circuit During Adolescent Development

STUDY_SECTION: BRLE

STUDY_SECTION_NAME: Biobehavioral Regulation, Learning and Ethology Study Section[BRLE]


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Endocrine Disruptors;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Effects of Indoor Air Pollution;Health Services;Human Genome;Pediatric;Prevention;Rural Health;Social Determinants of Health

ORG_CITY: SAN FRANCISCO

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: Narrative Our mixed methods study will use a bioethics environmental justice framework and collaboration with key community-based stakeholders to develop a home-based family child care intervention that will evaluate the impact of reporting back results of pesticides identified in the facilities on adoption of strategies to reduce pesticide exposure. The study will enroll family child care homes in marginalized, primarily Latinx, Central Valley counties in California. Qualitative and quantitative findings will inform the process of reporting back pesticide exposures, impact of reporting back as part of an integrated pest management intervention, and development of best practices for reporting back pesticide exposures in family child care homes.

PI_NAMEs: ALKON, ABBEY DIANE (contact)

PROGRAM_OFFICER_NAME: O'FALLON, LIAM

PROJECT_TERMS: Address;Adoption;Adult;Agriculture;Air;Back;Bioethics;Body System;Body Weight;California;care providers;Caring;Carpet;Chemical Exposure;Child;Child Care;Child Health;Cognitive;Collaborations;Communication;Communities;Comprehension;Confusion;Consultations;County;Data;Decision Making;Development;digital;Dust;Educational Materials;Educational workshop;Enrollment;Environmental Exposure;Environmental Hazards;Environmental Health;environmental justice;Ethical Issues;ethnic diversity;experience;Exposure to;Family;Food;Goals;Hand;Health;health goals;health inequalities;Home;Household;improved;Individual;Infant;Institutional Review Boards;Intake;Intention;Intervention;Intervention Studies;Interview;Knowledge;Knowledge Management;Latinx;Learning;Licensing;marginalization;marginalized community;Measurable;Measurement;Medial;meetings;Methods;Modification;Motivation;Neurologic;Oral cavity;Organophosphates;Outcome Study;Participant;patient home care;pediatrician;Persons;pesticide exposure;Pesticides;Phase;phase 3 study;Policies;post intervention;Practice Management;Predisposition;prevent;Process;programs;Provider;Public Health;pyrethroid;Qualitative Methods;Reaction;recruit;Reporting;Research;Research Design;Research Personnel;respiratory;response;Sampling;Self Efficacy;stem;Time;Toddler;tool;Water;Work;working group;Writing

PROJECT_TITLE: Best Practices to Return Results About Pesticide Exposures in Family Child Care Homes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 SEIR-P (80)]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Brain Disorders;Childhood Obesity;Clinical Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Nutrition;Obesity;Pediatric;Prevention

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE Obesity is a significant and lifelong threat to health and quality of life for the ~100,000 autistic youth who transition to adulthood each year in the United States. The transition to adulthood represents a critical window for obesity treatment, and there is no existing comprehensive treatment for obesity designed specifically for autistic individuals transitioning to adulthood. This project will identify a set of stakeholder-generated and prioritized testable treatment components that will lay the foundation for optimization of an obesity intervention for transition- age autistic youth that is stakeholder-accepted, effective, and maximized for implementation and community uptake.

PI_NAMEs: KUSCHNER, EMILY SARAH (contact)

PROGRAM_OFFICER_NAME: KAU, ALICE S

PROJECT_TERMS: adolescent health;adolescent with autism spectrum disorder;adult with autism spectrum disorder;Age;Age Years;Area;autism spectrum disorder;autistic;Behavior Therapy;Black Box;Body Image;Cardiovascular Diseases;Caregivers;Caring;Child Health;Childhood;Clinical;Communities;community advisory board;Control Locus;design;Development;Diet Modification;dietary;Dietitian;Eating Behavior;Effectiveness;Engineering;Equilibrium;Evaluation;evidence base;Family;Food;Foundations;fruits and vegetables;Goals;Health;Hospital Mortality;improved;Individual;individualized medicine;individuals with autism spectrum disorder;Intake;Intervention;intervention program;Interview;life span;Literature;Mediating;Methods;multiphase optimization strategy;National Institute of Child Health and Human Development;Non-Insulin-Dependent Diabetes Mellitus;Obesity;obesity in children;obesity treatment;parenting intervention;Parents;peer;Phase;Phenotype;Physical activity;Pilot Projects;pilot trial;Preparation;Prevalence;Prevention;programs;Provider;Psychologist;Qualitative Research;Quality of life;Research Design;Risk;Science;Structure;Testing;Text Messaging;therapy design;transition to adulthood;treatment optimization;treatment program;United States;uptake;Voice;Weight;Weight Perception;Work;Youth

PROJECT_TITLE: Preparing for Obesity Treatment Optimization: A Mixed Methods Study with Transition-Age Autistic Youth

STUDY_SECTION: LCBH

STUDY_SECTION_NAME: Lifestyle Change and Behavioral Health Study Section[LCBH]


ORG_CITY: DALLAS

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: To develop effective interventions for Parkinson's disease, it is crucial to understand the wide variety of conformations adopted by α-synuclein (α-syn) protein aggregates. This project aims to bridge the gap between in vitro and in vivo models by investigating how cellular environments influence the propagation of α-syn fibril conformations. By leveraging advanced sensitivity-enhancement technology and biosensor cell lines, we will gain atomic-level insights into the structural features of α-syn fibrils inside cells, facilitating the development of selective ligands for targeted therapies.

PI_NAMEs: FREDERICK, KENDRA KING (contact)

PROGRAM_OFFICER_NAME: SARRAF, SHIREEN AKHAVAN

PROJECT_TERMS: Acceleration;Address;Adopted;Affinity;alpha synuclein;Amyloid;Amyloid Fibrils;amyloid structure;Area;Binding;Binding Sites;Biological;Biosensor;Brain Diseases;Cell Line;Cell Survival;Cells;Chemicals;Cultured Cells;Data;design;Development;Diagnostic;Disease;Disease Progression;Drug Design;effective intervention;Electroporation;Enhancement Technology;Environment;Exposure to;Filament;Freezing;Glean;Growth;Image;improved;in silico;In Vitro;in vitro Model;in vivo;in vivo Model;insight;Isotope Labeling;Isotopes;Knowledge;Lewy Bodies;Ligands;Mammalian Cell;Mediating;Methods;Modeling;Molecular Chaperones;Molecular Conformation;Monitor;Mus;nanomolar;Nerve Degeneration;NMR Spectroscopy;novel;Nuclear;Nuclear Magnetic Resonance;Parkinson Disease;Pathology;Patients;Polymorph;Population;Positron-Emission Tomography;Prevalence;protein aggregation;Proteins;Protocols documentation;Reporter;Reporting;response;Sampling;screening;Site;Slice;small molecule;structural biology;Structure;synucleinopathy;targeted treatment;Technology;therapeutic development;Tissues;tool;Tracer;treatment response;Uncertainty;Work

PROJECT_TITLE: Determining the influence of cellular environments on a-synuclein fibril conformations

STUDY_SECTION: MSFB

STUDY_SECTION_NAME: Macromolecular Structure and Function B Study Section[MSFB]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Breast Cancer;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Rehabilitation;Social Determinants of Health;Women's Health Research

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: We hypothesize that stress plays a major role in health-related quality of life (HRQOL) among long-term breast cancer (BC) survivors. In this R21 pilot study, we will collect data on both individual-level (cancer-specific and social stressors) and neighborhood-level stressors and HRQOL for 270 long-term BC survivors, and collect blood samples to measure inflammatory biomarkers that may mediate the stressor-HRQOL relationships. The study findings will inform the design of a larger study of stress, inflammation, and HRQOL, as well as the development of targeted interventions to improve HRQOL for the growing number of long-term BC survivors.

PI_NAMEs: JOHN, ESTHER M. (contact)

PROGRAM_OFFICER_NAME: STRECK, BRENNAN PARMELEE

PROJECT_TERMS: Address;Affect;African American;aged;American;Asian Americans;Biological Markers;Blood specimen;breast cancer diagnosis;breast cancer family registry;breast cancer survival;Breast Cancer survivor;built environment;C-reactive protein;California;Cancer Patient;cancer survival;Cancer Survivorship;Caring;Censuses;Characteristics;cohort;Community Surveys;cytokine;Data;design;Development;Diagnosis;ethnic disparity;ethnic minority;ethnic minority population;Ethnic Origin;Event;experience;Financial Hardship;follow-up;Foundations;Future;Goals;Health;health disparity;health equity;health related quality of life;Hispanic;Hispanic Women;Immigrant;improved;Individual;Inflammation;Inflammatory;Intervention;Interview;Knowledge;Late Effects;Life;Long-Term Survivors;Malignant Neoplasms;Measures;Mediating;Mediator;member;multi-ethnic;Neighborhoods;Not Hispanic or Latino;Outcome;Participant;Patients;persistent symptom;Pilot Projects;Plasma;Play;Population;population based;Prevalence;prospective;Psychological Stress;Questionnaires;Race;racial disparity;racial minority;Reporting;Role;Sampling;social;Social Environment;social stress;social stressor;sociodemographics;Stress;stressor;Survivors;survivorship;Telephone;Update;Variant

PROJECT_TITLE: Stress, inflammation, and health-related quality of life of long-term breast cancer survivors

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-2 (J2)]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative How are specific neural circuits established in a cortex where neurons with different preferences are spatially intermixed? Here we consider the hypothesis that the visual properties of receptive fields of V1 neurons correlate with transcriptomic cell types, which also guide their projection patterns and orchestrate the wiring of local and long-range connections. The project addresses one of NEI’s strategic priorities: to improve the understanding of neural activity and molecular events in the formation of central visual circuits.

PI_NAMEs: RINGACH, DARIO L (contact)

PROGRAM_OFFICER_NAME: FLANDERS, MARTHA C

PROJECT_TERMS: 3-Dimensional;Address;Animals;Area;area striata;area V1;Calcium;Capsicum;Cell Differentiation process;cell type;Cells;cellular imaging;Contrast Sensitivity;Data;Databases;Event;excitatory neuron;experience;experimental study;extrastriate visual cortex;Fishes;Frequencies;Future;ganglion cell;Genetic;Glutamates;Image;improved;in vivo;Label;Location;Maps;Measures;Methodology;Molecular;Motion;Mus;neural;neural circuit;Neurons;novel;Pathway interactions;Pattern;Perfusion;Predisposition;preference;Process;programs;Property;receptive field;response;Retina;Signal Transduction;Sodium Chloride;Specificity;Stream;Structure;success;Tamoxifen;Testing;Tissues;transcriptomics;two-photon;V1 neuron;Vision;Visual;visual information;visual processing;visual stimulus;Work

PROJECT_TITLE: Visual function of transcriptomically defined glutamatergic neurons

STUDY_SECTION: NBVP

STUDY_SECTION_NAME: Neuroscience of Basic Visual Processes Study Section[NBVP]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Aging

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Project Narrative The rat has emerged as a surrogate for studying vocal fold atrophy due to the lack of accessible human donor larynges. However, the rat's thyroarytenoid muscle fiber composition differs from that of humans, raising concerns about the validity of rat models and our understanding of critical biochemical processes. This proposal aims to compare atrophic responses in muscles with varying fiber types to determine the relevance of fiber type in atrophy and ultimately develop novel therapeutic strategies for individuals with voice-related disabilities.

PI_NAMEs: GARTLING, GARY J (contact)

PROGRAM_OFFICER_NAME: KOPF, LISA MARIE

PROJECT_TERMS: Address;Affect;Age;age related;aged;Aging;aging population;Air Movements;Area;Atrophic;Biochemical Process;Cells;Communication;Complex;cricothyroid muscle;Data;Degradation Pathway;Denervation;Development;disability;Dysphonia;Elderly;Epithelium;Etiology;Fiber;Foundations;Functional disorder;Gastrocnemius Muscle;Gene Expression;Genes;genome-wide;Goals;Human;Iatrogenesis;Immobilization;improved;Individual;innovation;insight;Intervention;Knowledge;Lamina Propria;Laryngeal muscle structure;Larynx;Limb structure;Mediating;Modeling;multicatalytic endopeptidase complex;Muscle;Muscle Fibers;Muscle function;Muscular Atrophy;Myosin Heavy Chains;novel therapeutic intervention;Pathway interactions;Patients;Pattern;Persons;Phonation;Physiological;Physiology;Population;Predisposition;Prevalence;Process;Protein Biosynthesis;protein degradation;protein expression;Protein Isoforms;public health priorities;Quality of life;Rattus;Reporting;Research;response;Skeletal Muscle;skeletal muscle wasting;Slow-Twitch Muscle Fibers;Soleus Muscle;Structure;System;targeted treatment;Therapeutic;Thyroarytenoid Muscle;Time;Tissues;transcriptome sequencing;Translational Research;Ubiquitin;Up-Regulation;Validation;vocal cord;Voice;Work

PROJECT_TITLE: Advancing Voice Research in a Rat Model: Investigating the Impact of Fiber Type Composition and Underlying Mechanisms of Atrophy in Rat Thyroarytenoid and Skeletal Muscles

STUDY_SECTION: MFSR

STUDY_SECTION_NAME: Motor Function, Speech and Rehabilitation Study Section[MFSR]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Lung;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: CHAPEL HILL

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: NARRATIVE Endoscopies are commonly performed for various diagnostic purposes, and 3D understanding is typically done in the mind of the clinician performing the procedure and analyzing the endoscopy videos. However current state-of-the-art techniques for 3D reconstruction use camera motion only and do not work well or fail entirely for real organs since they lack strong geometric features, have highly reflective mucus layers, and often deform over time. In this project, we address these challenges by explicitly modeling the reflection of light from mucus layers and by accounting for time-varying deformation to obtain 3D reconstructions of unprecedented quality.

PI_NAMEs: SENGUPTA, RONI  (contact)

PROGRAM_OFFICER_NAME: DUAN, QI

PROJECT_TERMS: 3-Dimensional;Accounting;Address;Algorithms;Anus;Area;Automobile Driving;Back;Biological Models;Breathing;Characteristics;Clinical;Colon;Computer Graphics;Computer Vision Systems;Consumption;Data;deep neural network;Diagnosis;Diagnostic;diagnostic accuracy;Endoscopes;Endoscopy;Ensure;Exhibits;experience;flexibility;Gastrointestinal tract structure;Goals;Growth;Hemorrhoids;high risk;Human;Human Resources;Imaging Techniques;improved;Infection;innovation;interest;learning algorithm;Light;Lighting;Lower respiratory tract structure;Lung;Machine Learning;Maps;Measurement;Measures;Medical;Methodology;Methods;Mind;minimally invasive;Modeling;Motion;Mucous body substance;Network-based;next generation;novel;Oral cavity;Organ;Outcome;Pathway interactions;Patients;Phase;Physicians;Play;Polyps;Positioning Attribute;Procedures;Property;Radiation;reconstruction;Relaxation;Research Personnel;respiratory;Respiratory System;Retinal blind spot;Robot;Role;Screening for cancer;Shapes;skills;success;Surface;Surveys;synthetic data;System;Techniques;three-dimensional modeling;Time;Tissues;Tube;Ulcer;Upper respiratory tract;Urinary tract;Variant;Visualization;Work;X-Ray Computed Tomography

PROJECT_TITLE: Next-gen 3D Modeling of Endoscopy Videos

STUDY_SECTION: ITD

STUDY_SECTION_NAME: Imaging Technology Development Study Section[ITD]


NIH_SPENDING_CATS: American Indian or Alaska Native;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Effects of Indoor Air Pollution;Human Genome;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: SALT LAKE CITY

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: NARRATIVE The overall objective of this proposal is to optimize, validate, and evaluate the effectiveness of strategies for reporting back environmental sampling results to rural Native American populations, with a focus on the balance between real-time and delayed feedback for both acute and chronic exposure concerns. The bioethical question of interest is: How does the information source (i.e., the messenger, format, and/or timing of education) impact the effectiveness of report-back strategies in rural tribal populations? The ultimate outputs of this work will be a set of validated guidance on the most effective approaches, with a focus on increasing engagement with exposure-reduction activities in rural tribal populations, informing the broader research community, and helping build local capacity for the sustainability of evaluation activities in these populations.

PI_NAMEs: COLLINGWOOD, SCOTT CHARLES;SLEETH, DARRAH KAYE (contact)

PROJECT_TERMS: Acute;Address;Air Pollution;Arapaho;Back;Chronic;citizen science;Collection;Communication;Communities;community advisory board;Data;design;Disparity population;Education;Educational Materials;Effectiveness;effectiveness evaluation;Elderly;Enrollment;Environmental Exposure;Environmental Health;Equilibrium;Evaluation;Evaluation Reports;Feedback;fine particles;Focus Groups;follow-up;frontier;Future;Goals;Grant;Health;health equity;Home;Household;improved;Individual;innovation;Institution;Institutional Review Boards;interest;Left;Location;maltreatment;Methods;Monitor;National Institute of Environmental Health Sciences;Native American population;Native American Tribe;Native Americans;Navajo;Outcome;Output;Participant;patient engagement;Persons;Play;Population;pragmatic implementation;programs;Questionnaires;Radon;Reading;Reporting;Research;Risk;Role;Rural;Sampling;Series;Source;Techniques;Testing;Time;Tribal group;tribal member;tribal organization;Tribes;Utah;Validation;Work

PROJECT_TITLE: Evaluation of Report-Back Strategies for Long-term and Short-term Exposure Information in Rural Tribal Populations


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Kidney Disease

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: PROJECT NARRATIVE Kidney disease is a common complication for patients with diabetes that can progress to kidney failure and death and our research has shown that the hormone aldosterone may play an important role in causing kidney disease in patients with diabetes. Since there are widely available medications that can prevent aldosterone- mediated kidney disease, it is critical to understand how aldosterone may cause diabetic-kidney disease. This proposal will investigate the presence of excess aldosterone among people with diabetes to characterize whether aldosterone-blocking medications may prevent kidney disease in this population.

PI_NAMEs: VAIDYA, ANAND  (contact)

PROGRAM_OFFICER_NAME: PARSA, AFSHIN

PROJECT_TERMS: absorption;Acceleration;adverse outcome;Albuminuria;Aldosterone;antagonist;Biological Markers;Cardiovascular Diseases;cardiovascular disorder risk;Cardiovascular system;Cessation of life;Chronic Kidney Failure;clinical practice;cohort;Cohort Studies;Complication;CYP11B2 gene;Data;design;Development;Diabetes Mellitus;Diabetic Nephropathy;Dialysis procedure;Disease Progression;End stage renal failure;Excretory function;experience;extracellular vesicles;Fibrosis;follow-up;Foundations;Functional disorder;Funding;General Population;Health Expenditures;high risk;high risk population;Hormones;Hybrids;Hyperaldosteronism;improved;Individual;Inflammation;Infrastructure;inhibitor;Injury to Kidney;innovation;Kidney;Kidney Diseases;Kidney Failure;kidney fibrosis;kidney vascular structure;Knowledge;Measurement;Measures;Mediating;Mineralocorticoid Receptor;multidisciplinary;National Institute of Diabetes and Digestive and Kidney Diseases;novel;Outcome;Participant;Pathogenicity;Pathologic;Pathology;Patients;Persons;Pharmaceutical Preparations;Phenotype;Play;Population;Prevalence;prevent;Production;prospective;protein biomarkers;Proteins;Proteinuria;Proteomics;Protocols documentation;Public Health;Quality of life;randomized, clinical trials;Receptor Activation;Renin;Research;Risk;Role;Severities;Sodium;Steroids;Syndrome;targeted treatment;Testing;urinary;Vascular Diseases;Water;Work

PROJECT_TITLE: Unrecognized Primary Aldosteronism as a Pathogenic Mechanism for Chronic Kidney Disease in Diabetes

STUDY_SECTION: ICER

STUDY_SECTION_NAME: Integrative and Clinical Endocrinology and Reproduction Study Section[ICER]


NIH_SPENDING_CATS: Aging;Brain Disorders;Infectious Diseases;Microbiome;Neurodegenerative;Neurosciences;Parkinson's Disease

ORG_DEPT: BIOPHYSICS

PHR: PROJECT NARRATIVE Levodopa (L-dopa) remains the front-line therapy for treatment of motor disorders associated with Parkinson’s disease. However, metabolism by the gut microbiome reduces the concentration of L-dopa available for uptake into the brain, complicates determination of optimal dosage, and may contribute to the need for dose escalation over the course of the disease. Treatment with a probiotic that mitigates L-dopa metabolism by the gut microbiome is a promising and novel approach to enhance the effectiveness of oral L-dopa therapy in Parkinson’s disease.

PI_NAMEs: FEIX, JIMMY  (contact)

PROGRAM_OFFICER_NAME: SIEBER, BETH-ANNE

PROJECT_TERMS: Affect;Aging;Aromatic-L-Amino-Acid Decarboxylases;associated symptom;bacterial metabolism;bacteriocin;behavior measurement;Blood;blood-brain barrier crossing;Bradykinesia;Brain;Carbidopa;Carboxy-Lyases;decarboxylase inhibitor;Decarboxylation;Development;Disease;Dopamine;dopaminergic neuron;dosage;Dose;Effectiveness;Engineering;Enterococcus;Enterococcus faecalis;Gastrointestinal tract structure;Genes;gut microbiome;gut microbiota;improved;Indigenous;individual variation;Infection prevention;Knock-out;L-DOPA induced dyskinesia;Levodopa;Measures;Mediating;member;Metabolism;microbial;microbiome;Midbrain structure;Motor;motor control;motor deficit;motor disorder;motor symptom;mouse model;Multi-Drug Resistance;Mus;mutant;Neurodegenerative Disorders;Neurotransmitters;novel strategies;Operon;Oral;Oral Administration;Parkinson Disease;Patients;Physiological;posture instability;prevent;Probiotics;Quality of life;response;Rifampicin resistance;Risk;Serum;Substantia nigra structure;System;Testing;Time;Tyrosine;uptake;Variant;Withdrawal

PROJECT_TITLE: Modifying the microbiome to enhance L-dopa therapy in Parkinson’s disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 AN-Z (55)]


NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Biomedical Imaging;Brain Disorders;Cerebrovascular;Childhood Injury;Clinical Research;Hematology;Infant Mortality;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Stroke;Unintentional Childhood Injury

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative There is a need for non-invasive, real-time bedside tools to monitor brain health in newborns with hypoxic-ischemic encephalopathy (HIE) at risk for brain injury. We propose a novel, low- cost, wearable near infrared spectroscopy (NIRS) device able to continuously measure the oxidation state of cytochrome c (oxCCO), a marker of cerebral metabolism, in newborns at risk for brain injury after hypoxia-ischemia. The successful development, validation, and demonstration of clinical feasibility and effectiveness of this proposed technology will lead to the opportunity to intervene at the bedside to reduce brain injury and improve neurodevelopmental outcome.

PI_NAMEs: HERZBERG, EMILY MARIE (contact)

PROGRAM_OFFICER_NAME: DOPERALSKI, ADELE ELIZABETH

PROJECT_TERMS: Admission activity;Affect;Bilateral;Biological Markers;Bluetooth;Brain;brain health;Brain Hypoxia-Ischemia;Brain Injuries;brain magnetic resonance imaging;Cell Death;Cerebral Dominance;cerebral hemodynamics;cerebral oxygenation;Cerebrum;Cessation of life;Classification;Clinical;Color;cost;Custom;cytochrome c;cytochrome c oxidase;Data;design;Detection;Development;Devices;disability;Discrimination;Effectiveness;Electron Transport;Energy Metabolism;ergonomics;Failure;Family;Frequencies;Future;General Hospitals;Goals;Hemoglobin;Hemoglobin C;Hospitals;Hour;Human;hypoxic ischemic injury;improved;improved outcome;Infant;infant monitoring;Intervention;Ischemia;Live Birth;Magnetic Resonance Imaging;Massachusetts;Measurement;Measures;Metabolism;Methods;Mitochondria;Modality;Monitor;natural hypothermia;Near-Infrared Spectroscopy;neonatal hypoxic-ischemic brain injury;Neonatal Intensive Care Units;neonatal morbidity;Neonatal Mortality;neonate;Newborn Infant;novel;Optical Methods;Outcome;outcome prediction;oxidation;Oxidative Phosphorylation;Oxidative Stress;Oxygen;Oxygen saturation measurement;Performance;Pilot Projects;prevent;prognostic;prognostication;prototype;Public Health;Randomized, Controlled Trials;Recording of previous events;Respiratory distress;Rewarming;Risk;Sampling;sensor;Severities;smartphone application;Spectrum Analysis;success;System;Tablets;Technology;Term Birth;Testing;Therapeutic;Time;Time Management;tool;treatment response;Validation;wearable device;wireless;Work

PROJECT_TITLE: Wearable NIRS Device for Continuous Monitoring of Cytochrome C Oxidase in Hypoxic Ischemic Encephalopathy

STUDY_SECTION: BNVT

STUDY_SECTION_NAME: Bioengineering of Neuroscience, Vision and Low Vision Technologies Study Section[BNVT]


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: TALLAHASSEE

ORG_DEPT: PSYCHOLOGY

ORG_NAME: FLORIDA STATE UNIVERSITY

PHR: PROJECT NARRATIVE Multiple factors have been found to hinder older adults’ ability to fully optimize their use of patient portals and their ability to retrieve and understand lab test results. In this project, we will employ a user-centered approach to develop and evaluate a working prototype of a patient-engagement tool called LabGenie specifically designed to aid older adults’ comprehension of lab results by providing visualizations of lab test results and tailored question prompts to help them prepare for follow-up consultations. Our long-term goal is to integrate these innovative technologies and approaches into patient portals and to conduct a large-scale randomized controlled trial to evaluate the efficacy of the enhanced system on improving older adults' self-management of chronic conditions.

PI_NAMEs: HE, ZHE  (contact);LUSTRIA, MIA LIZA A.

PROGRAM_OFFICER_NAME: CHANEY, KEVIN

PROJECT_TITLE: LabGenie: A Patient-Engagement Tool to Aid Older Adults' Understanding of Lab Test Results

STUDY_SECTION: HITR

STUDY_SECTION_NAME: Healthcare Information Technology Research[HITR]


NIH_SPENDING_CATS: Bioengineering;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences

ORG_CITY: SYRACUSE

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UPSTATE MEDICAL UNIVERSITY

PHR: PROJECT NARRATIVE Glaucoma is a leading cause of irreversible blindness worldwide, but the mechanisms underlying optic nerve damage are poorly understood. This is partly due to a lack of adequate model systems to test mechanisms of optic nerve cellular dysfunction. This proposal aims to develop a 3D model system of human optic nerve head cells to test how pathologic mechanical strains induce tissue fibrosis.

PI_NAMEs: GANAPATHY, PREETHI  (contact);MCDOWELL, COLLEEN MARY

PROGRAM_OFFICER_NAME: SONG, HONGMAN

PROJECT_TERMS: 3-Dimensional;Address;Affect;Astrocytes;Binding;Biological Models;Bioreactors;Blindness;cell type;Cells;Coculture Techniques;Collagen Type IV;Custom;Data;Deposition;Development;Encapsulated;experimental study;Fibronectins;Fibrosis;Functional disorder;Future;Glaucoma;Goals;Human;Hydrogels;In Vitro;in vivo;in vivo Model;knock-down;Knowledge;Measures;Mechanics;Modeling;Molecular;nerve damage;neural;Neurons;Optic Disk;Optic Nerve;Pathologic;Pathway interactions;pharmacologic;Physiological;Primates;Production;profibrotic cytokine;Protein Isoforms;Proteins;response;Rodent;Rodent Model;Role;Signal Pathway;Signal Transduction;Signaling Molecule;System;Testing;three dimensional cell culture;three-dimensional modeling;Time;Tissues;TLR4 gene;Transforming Growth Factors;Work

PROJECT_TITLE: Optic nerve head cellular interactions in response to mechanical strain and fibrosis

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 1 Study Section[PED1]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Breast Cancer;Cancer;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: MOBILE

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF SOUTH ALABAMA

ORG_STATE: AL

PHR: PROJECT NARRATIVE Triple negative breast cancer is a frequently recurring and metastatic disease with dismal survival rate among the African American (AA) compared to the European American (EA) women. Early detection of the aggressive lesions and their recurrent prediction may significantly reduce the disparity gaps in terms of disease associated morbidity and mortality. The present study aims to develop an mtDNA based novel liquid biomarker tool for early detection and monitoring of the racially disparate population to ultimately improve their overall survival.

PI_NAMEs: DASGUPTA, SANTANU  (contact)

PROGRAM_OFFICER_NAME: LAI, GABRIEL Y

PROJECT_TERMS: African American;African American Women;Age;American;Biological Assay;Biological Markers;biomarker development;Birth;Breast Cancer Patient;cancer cell;Cataloging;Cells;Circulation;Clinical;clinically significant;Code;cohort;Complex;Detection;Development;Disease;Disparate;disparity gap;Disparity population;disparity reduction;DNA;Early Diagnosis;European;Event;extracellular vesicles;Fingerprint;Generations;Genes;Genetic;Genome;Growth;Haplotypes;Heterogeneity;Human;improved;Invasive Lesion;Legal patent;Lesion;Lipids;Liquid substance;Malignant Breast Neoplasm;Malignant Neoplasms;Measurable;Measures;Metabolism;Metastatic/Recurrent;Mitochondria;Mitochondrial Diseases;Mitochondrial DNA;mitochondrial DNA alteration;mitochondrial DNA mutation;mitochondrial genome;Monitor;Morbidity - disease rate;mortality;Mutation;Mutation Detection;Neoplasm Metastasis;next generation sequencing;novel;novel strategies;Nuclear;Nucleic Acids;Organelles;Outcome;outcome disparities;Oxidative Phosphorylation;patient population;Patient Self-Report;Patients;Pattern;Performance;Play;polypeptide;protein expression;Proteins;Race;racial disparity;Randomized;Recurrence;Recurrent tumor;Research;Research Design;Resources;respiratory;Ribosomal RNA;Role;Sampling;Serum;Specificity;Survival Rate;System;Therapeutic;tissue fixing;Tissue Sample;tool;Transfer RNA;treatment planning;treatment response;triple-negative invasive breast carcinoma;tumor;tumor metabolism;tumor progression;tumorigenesis;Validation;Woman

PROJECT_TITLE: Mitochondrial DNA in extracellular vesicles for early detection and recurrence prediction in triple negative breast cancer racial disparity

STUDY_SECTION: BMCD

STUDY_SECTION_NAME: Basic Mechanisms of Cancer Health Disparities Study Section[BMCD]


NIH_SPENDING_CATS: Neurosciences

ORG_CITY: HERSHEY

ORG_DEPT: PHYSIOLOGY

ORG_NAME: PENNSYLVANIA STATE UNIV HERSHEY MED CTR

PHR: Project Narrative Mitochondrial ATP synthase houses a leak channel that is activated during ischemia/reperfusion (I/R) injury. This project will investigate the single-particle cryo-EM structure of Artemia franciscana ATP synthase, a mysterious organism that tolerates profound calcium concentrations and survives anoxic conditions for years. Successful completion of this project will reveal distinct structural features of ATP synthase that enable brine shrimp to resist extreme anoxic conditions and will unlock the development of new therapeutics for treating I/R injuries.

PI_NAMEs: MNATSAKANYAN, NELLI  (contact)

PROGRAM_OFFICER_NAME: UMANAH, GEORGE KWABENA ESSIEN

PROJECT_TERMS: Adenine Nucleotides;Artemia;Biology;biophysical properties;Calcium;Cell Death;Cell Death Induction;Cell Physiology;cellular pathology;Cerebral Ischemia;comparative;Cryoelectron Microscopy;cytochrome c;Detergents;Development;Disease;Electrophysiology (science);Embryo;Energy Metabolism;Engineering;excitotoxicity;Family suidae;Franciscana;Glutamates;Heart;Heart Mitochondria;Hippocampus;Hypoxia;inhibitor;Injury;Inner mitochondrial membrane;Ions;Ischemia;Lipid Bilayers;Mammals;Membrane;Mitochondria;mitochondrial dysfunction;mitochondrial permeability transition pore;Mitochondrial Proteins;Mitochondrial Proton-Translocating ATPases;Mitochondrial Swelling;Molecular;Molecular Conformation;neuron loss;neuronal survival;Neurons;new therapeutic target;novel therapeutics;Organism;Outer Mitochondrial Membrane;overexpression;particle;patch clamp;Pathway interactions;Permeability;Play;prevent;Property;Rattus;Regulation;Reperfusion Injury;Reporting;Research;resilience;Resistance;Resolution;Respiration;Role;Rupture;Structure;Swelling;Testing;Therapeutic;Tissues;Vesicle;voltage

PROJECT_TITLE: Mitochondrial resilience mechanisms of extremophile brine shrimp Artemia

STUDY_SECTION: BBM

STUDY_SECTION_NAME: Biochemistry and Biophysics of Membranes Study Section[BBM]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering

ORG_DEPT: ANATOMY/CELL BIOLOGY

PHR: PROJECT NARRATIVE In order to understand the function of molecules inside living cells (such as proteins and DNA), we need tools that can visualize these molecules at a high level of detail. Although cryo-electron microscopy and tomography imaging allow researchers to visualize the 3D structure of life-like preserved molecules, both purified and inside unperturbed cells, there are still technical limitations (e.g., localization and identification of molecules in cryo-tomograms) that can be improved. Therefore, we propose to develop new tools and strategies to address these limitations so that we can better understand the structure and function of biomolecules, and the inner workings of cells in health and disease, and to potentially use this knowledge to design effective therapeutic treatments.

PI_NAMEs: NICASTRO, DANIELA  (contact)

PROGRAM_OFFICER_NAME: FLICKER, PAULA F

PROJECT_TERMS: 3-Dimensional;Address;Bacteriophages;Biological;Biological Models;Biology;Breathing;Capsid;Cells;Cellular biology;chemical bond;chemical reaction;Chemicals;Complex;Crowding;Cryo-electron tomography;Cryoelectron Microscopy;cryogenics;Cytoplasmic Granules;Data;design;detector;Deuterium Oxide;Development;Disease;DNA;Dose;Electron Beam;electron energy;electron tomography;Electrons;Environment;Escherichia coli;Event;Freezing;Functional disorder;Gases;Generations;Goals;Health;Hydration status;Hydrogen;Hydroxyl Radical;Hypersensitivity;Ice;Image;imaging approach;Imaging Device;Imaging Techniques;improved;In Situ;In Vitro;in vivo;insight;ionization;Knowledge;Label;Life;Lipids;Macromolecular Complexes;macromolecule;Methods;microscopic imaging;Modernization;Molecular;Molecular Machines;Molecular Structure;nanometer;nanoscale;Noise;novel strategies;Organelles;particle;Preparation;preservation;protein function;protein structure;Proteins;Proteomics;Radiation;Radiation induced damage;Radiation Tolerance;reconstruction;Research;Research Personnel;Resolution;Ribosomes;Sampling;Signal Transduction;spatiotemporal;Specimen;Speed;Starch;Stress;Structure;System;Techniques;Temperature;therapeutically effective;three dimensional structure;three-dimensional visualization;Time;Tomogram;tool;Virus;Visualization;Water;Yeasts

PROJECT_TITLE: Altering electron-induced radiolysis to optimize cryo-EM/ET imaging

STUDY_SECTION: EBIT

STUDY_SECTION_NAME: Enabling Bioanalytical and Imaging Technologies Study Section[EBIT]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE Racial/ethnic inequities in chemical exposures from consumer product use are shaped by social-structural factors and can amplify health disparities across the life course. Reporting back research results to individuals can help advance environmental health literacy and drive collective action; however, we currently lack best practices for ethical report back of consumer product chemical data to multiply marginalized groups. This project will build on an existing community-engaged consumer product exposure study (Taking Stock) in order to enhance current report back methods by centering intersectionality and to advance the field from right-to-know to right-to-understand.

PI_NAMEs: DODSON, ROBIN E.;SHAMASUNDER, BHAVNA ;ZOTA, AMI R (contact)

PROGRAM_OFFICER_NAME: MCALLISTER, KIMBERLY A

PROJECT_TERMS: Address;Adopted;Advocacy;Back;Beauty;Biological Monitoring;Black race;black women;Chemical Exposure;Chemicals;classism;Communication;Communities;community academic partnership;community based participatory research;community building;community partners;consumer product;Data;design;digital;Discrimination;Educational Intervention;Educational workshop;effectiveness evaluation;Environmental Health;environmental justice;Ethics;ethnic disparity;experience;Exposure to;Feedback;Funding;Gender;Goals;Hair;health data;health disparity;health equity;health inequalities;health literacy;hormone related cancer;improved;Individual;intersectionality;Intervention Studies;Interview;Justice;Knowledge;Latina;Learning;Life Cycle Stages;Link;Los Angeles;Malignant Breast Neoplasm;marginalized population;meetings;Methods;Motivation;Neighborhoods;Outcome;Participant;Patient Recruitments;Pattern;pedagogy;personal care products;Persons;Phase;Positioning Attribute;Pregnancy Complications;pressure;Process;Race;racism;Reporting;reproductive;Research;Research Personnel;research study;Risk;Sexism;Shapes;smartphone application;Social Identification;social structure;Socioeconomic Status;structural determinants;Structural Racism;Surveys;System;Testing;Time;tool;Trust;usability;Woman;women of color;Work

PROJECT_TITLE: Reframing personal and community report back of consumer products by centering intersectionality


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Kidney Disease;Liver Disease;Nutrition;Obesity;Urologic Diseases

ORG_CITY: BIRMINGHAM

ORG_DEPT: UROLOGY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

PHR: NARRATIVE Elevated urinary oxalate excretion heightens the risk of calcium oxalate kidney stone formation and may increase the risk of progression of chronic kidney disease. Non-alcoholic fatty liver disease which affects approximately 25% of the US population is associated with increased urinary oxalate excretion. The goal of this project is to generate preliminary data for a larger multi-disciplinary/multi-institutional NIH application focused on the mechanisms of endogenous oxalate synthesis in calcium oxalate kidney stone formers with and without NAFLD.

PI_NAMEs: WOOD, KYLE D (contact)

PROGRAM_OFFICER_NAME: RANKIN, TRACY L

PROJECT_TERMS: Adolescent obesity;Adult;Affect;Alanine;Alanine-glyoxylate aminotransferase;Antioxidants;Ascorbic Acid;Award;Biopsy;Body Composition;Calcium Oxalate;Carbon;Caring;Chronic Kidney Failure;Cirrhosis;cohort;Collection;Data;Development;Diet;dietary;Disease;Dose;Enzymes;Excretory function;experimental study;Fasting;Fatty acid glycerol esters;Fatty Liver;Feasibility Studies;Future;General Population;Genes;Glycolates;glyoxylate;Goals;Hour;Human;human study;Image;Individual;Inflammation;insight;Institution;Kidney Calculi;Label;Liver;liver biopsy;Liver diseases;Liver Fibrosis;liver inflammation;Measurement;Messenger RNA;metabolic abnormality assessment;Metabolic Marker;Metabolic Pathway;Metabolic syndrome;Metabolism;Methods;mouse model;multidisciplinary;non-alcoholic fatty liver disease;novel strategies;Obesity;obesity in children;Oral;Oral Administration;Overweight;Oxalates;Oxidative Stress;Patients;Pilot Projects;Plasma;Population;Portal Hypertension;Production;progression risk;recruit;Renal function;Reporting;Research;Research Personnel;Risk;Risk Factors;Sampling;Severities;simple steatosis;Source;Testing;Tissues;Transaminases;Triglycerides;United States;United States National Institutes of Health;urinary;Urine

PROJECT_TITLE: Non-alcoholic Fatty Liver Disease and Endogenous Oxalate Synthesis

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Public Health Relevance/Narrative Understanding the complex workings of the immune system is crucial for the relevance of health and disease, as it serves as our body's intricate defense mechanism against illnesses. The development of a label-free dynamic imaging tool is essential to further this understanding. By enabling real-time observation of immune cells in their natural state, this tool can potentially facilitate personalized treatment approaches and ultimately improve health outcomes for individuals.

PI_NAMEs: FU, DAN  (contact)

PROGRAM_OFFICER_NAME: MALLIA, CONRAD M

PROJECT_TERMS: 3-Dimensional;Address;Adopted;Animals;Autoimmune Diseases;Behavior;Biological Models;Blood;Blood capillaries;Brain;cancer immunotherapy;CD4 Positive T Lymphocytes;CD8B1 gene;Cell Communication;Cell Line;cell motility;cell type;Cells;Chemicals;Classification;Complex;Consumption;data acquisition;Data Set;deep learning;deep learning algorithm;deep learning model;Defense Mechanisms;Development;Diagnosis;Disease;Dissociation;exhaust;exhaustion;Flow Cytometry;genetic manipulation;Goals;Health;Heterogeneity;human tissue;Image;Imaging Device;Imaging Techniques;Immune;immune function;Immune response;Immune system;Immunofluorescence Immunologic;Immunologic Techniques;improved;In Situ;in vivo;Individual;Infection;innovation;insight;instrumentation;intravital microscopy;Label;Lymph Node Tissue;lymph nodes;Machine Learning;Malignant Neoplasms;Measurement;Memory;Microscope;Microscopy;Modeling;Morphology;Mus;Nature;Nerve Degeneration;Neurodegenerative Disorders;new technology;optical imaging;Outcome;pathogen;Pathology;Periodicity;personalized medicine;Pharmacotherapy;Play;public health relevance;Raman Spectrum Analysis;Resolution;response;Role;Sampling;Scanning;self organization;Seminal;serial imaging;signature molecule;Slice;Sorting;spatiotemporal;Specificity;Speed;Spleen;Stains;Stimulus;T-Lymphocyte;Techniques;Technology;technology development;Testing;Thinness;Time;Tissues;tool;Training;transcriptomics;Transgenic Mice;Translating;tumor;Tumor Tissue;Validation;virtual

PROJECT_TITLE: Dynamic immune profiling in live tissue through multiplexed virtual staining

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BBBT-M (82)]


ED_INST_TYPE: OTHER SPECIALIZED SCHOOLS

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging

ORG_CITY: Princeton

ORG_DEPT: MISCELLANEOUS

ORG_NAME: PRINCETON UNIVERSITY

ORG_STATE: NJ

PHR: Project Narrative Light sheet fluorescence microscopy has greatly expanded our capability to visualize, track and quantify biological dynamics with high spatiotemporal resolution, but its adoption in biomedical research is limited due to its incompatibility with widely used high-throughput sample holders like multi-well plates or microfluidic chips. Our proposal aims to address this incompatibility issue by integrating optical metasurfaces with light sheet fluorescence microscopy, enabling the development of open-top light sheet imaging systems for high-throughput noninvasive 4D imaging in live cells and multicellular organisms. To demonstrate the efficacy of our approach, we will develope a metasurface-integrated lattice light sheet microscope and apply it for high-content molecular dynamic mapping of chimeric antigen receptor T (CAR-T) cells and organelle profiling of zebrafish development.

PI_NAMEs: FU, TIAN-MING  (contact)

PROGRAM_OFFICER_NAME: ANDERSON, AFROUZ AZARI

PROJECT_TITLE: Metasurface-Integrated Open-Top Lattice Light Sheet Microscope for High-Throughput Bioimaging


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Drug Abuse (NIDA only);Health Services;Substance Misuse

ORG_CITY: LITTLE ROCK

ORG_NAME: UNIV OF ARKANSAS FOR MED SCIS

ORG_STATE: AR

PHR: Substance use disorders such as opioid addiction affect millions of adults in the United States each year, but the delivery of high-quality, effective addiction services is disrupted by organizational issues such as counselor burnout and turnover. Clinical supervisors are essential for supporting counselors in specialty addiction treatment programs, but few supervisors receive supervision-focused training. This project seeks to develop and pilot an evidence-based supervision strategy that has a high potential to enhance supervision and result in improved counselors’ well-being and performance and, in turn, to improve client outcomes.

PI_NAMEs: BALOH, JURE  (contact)

PROGRAM_OFFICER_NAME: LYNCH, SEAN EDWARD WINTERS

PROJECT_TERMS: acceptability and feasibility;addiction;Address;Adult;Affect;Alcohols;Area;Arkansas;Behavior;Behavioral;burnout;Child Welfare;Client;Climate;Clinical;clinical care;Clinical effectiveness;Communities;community engaged approach;design;Development;effective therapy;Effectiveness;effectiveness evaluation;effectiveness/implementation hybrid;Ensure;evidence base;Evidence based intervention;Feedback;Frontline worker;Future;Goals;hybrid type 1 trial;implementation science;improved;Individual;Justice;Language;Leadership;Manuals;Measurement;Measures;Mediating;medical specialties;meetings;Methamphetamine;Methods;Modification;National Institute of Drug Abuse;Nature;Opiate Addiction;Opioid;Outcome;Output;Participant;Performance;Personal Satisfaction;pilot test;Positioning Attribute;practice setting;Preparation;Procedures;Process;process improvement;Professional counselor;programs;Provider;Qualitative Methods;Research;Research Support;Residential Treatment;Role;Sampling;scale up;Series;service delivery;service organization;Services;social cognitive theory;Strategic Planning;Structure;Substance Use Disorder;substance use treatment;Supervision;System;Task Performances;Testing;tool;Training;treatment program;United States;Work

PROJECT_TITLE: Developing and Piloting a Supervision Strategy for Substance Use Disorder Treatment Programs

STUDY_SECTION: ODHS

STUDY_SECTION_NAME: Organization and Delivery of Health Services Study Section[ODHS]


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

ORG_CITY: Chicago

ORG_DEPT: CHEMISTRY

ORG_NAME: NORTHWESTERN UNIVERSITY

ORG_STATE: IL

PHR: PROJECT NARRATIVE We aim to acquire a state-of-the-art high-power pulsed Q-band Electron Paramagnetic Resonance (EPR) spectrometer as a multi-user shared instrument, to be managed by the Integrated Molecular Structure Education and Research Center (IMSERC) facility. The research scope of the major users is broad, and ranges from structural biology of folded proteins and intrinsically disordered proteins that are targets for therapeutics development, or of biomolecular assembly that serve as platforms to modulate live cellular activities. This will be the first pulsed Q-band EPR instrument established at NU for a shared user facility, with a critical focus on dissemination of the powerful EPR structural biology tools to a broad user base by establishing robust workflows for sample preparation, measurements, sample storage and automated data processing.

PI_NAMEs: HAN, SONGI  (contact)

PROGRAM_OFFICER_NAME: AGGARWAL, MONIKA

PROJECT_TERMS: Amplifiers;Area;Chicago;Collaborations;Coupled;Coupling;cryostat;Data;Data Science;Disease;Education;Electron Nuclear Double Resonance;Electron Spin Resonance Spectroscopy;Electrons;experimental study;Frequencies;Generations;Goals;Hour;innovation;instrument;Measurement;Methods;microwave electromagnetic radiation;Molecular Structure;novel therapeutics;Nuclear;operation;Physiologic pulse;Process;protein folding;Proteins;quantum information science;Relaxation;Research;Resources;Sampling;Scanning;Signal Transduction;Spin Labels;structural biology;System;Testing;Therapeutic Agents;Time;tool;Transition Elements;Universities

PROJECT_TITLE: Pulsed Q-band Electron Paramagnetic Resonance Spectrometer for Structural Biology Applications

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MBBC-V (32)]


NIH_SPENDING_CATS: Congenital Structural Anomalies;Estrogen;Genetics;Neurosciences;Orphan Drug;Pediatric;Rare Diseases

ORG_CITY: SAN MARCOS

ORG_NAME: NEUROSANT THERAPEUTICS LLC

PHR: Project Narrative Smith-Magenis syndrome (SMS) is an autosomal dominant neurodevelopmental disorder characterized by the deletion of one Rai1 allele (Retinoic Acid Induced-1). As a transcription factor, this deletion causes a reduction in Rai1 expression and concomitant changes in expression of downstream targets, many critical to neurodevelopment and function. We have assembled a small library that were selected based on their ability to increase Rai1 expression. Our overarching goal is to demonstrate that Rai1 expression in SMS can be increased using a pharmacologic approach and many of the transcriptomic defects can be corrected.

PI_NAMEs: DEFREES, SHAWN  (contact);HUANG, WEI-HSIANG

PROGRAM_OFFICER_NAME: PAWLYK, AARON C

PROJECT_TERMS: 17p11.2;Adolescence;Adverse event;Affect;Alleles;analog;Analysis of Variance;Animal Testing;Animals;autosome;Behavior;Behavioral;behavioral phenotyping;Biochemical;Biodistribution;Biological Assay;Brain;Brain-Derived Neurotrophic Factor;Caring;Cells;Chromosomes;Defect;Development;Disease;disease phenotype;DNA cassette;Dose;Drug Kinetics;drug market;efficacy evaluation;Estrogen Analogues;Estrogen deficiency;Estrogens;Family;Fibroblasts;Functional disorder;Gene Expression;Genes;Genetic Transcription;Goals;Human;human subject;Hypothalamic structure;improved;in vivo evaluation;Infant;Lead;Libraries;Literature;LoxP-flanked allele;Measures;Mediating;Messenger RNA;Metabolic Clearance Rate;meter;Methods;Molecular;Motor;mouse model;Mus;Mutation;neural;neurobehavioral;neurodevelopment;Neurodevelopmental Disorder;Neurologic;Outcome;Patients;Penetration;Pharmacodynamics;pharmacologic;Phenotype;Physiological;Plasma;preadolescence;promoter;Property;protein expression;Protein Isoforms;Proteins;psychologic;Replacement Therapy;response;Retinoids;Schedule;Selective Estrogen Receptor Modulators;Smith Magenis syndrome;Social Dominance;Students;System;targeted agent;Testing;Therapeutic;Time;transcription factor;transcriptomics;Tretinoin

PROJECT_TITLE: Therapeutics that Correct the Underlying Cause of Smith-Magenis Syndrome (SMS)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-M (81)]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Palliative Care;Social Determinants of Health

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE Sexual and gender minority (SGM) individuals are often diagnosed with late-stage cancer and often die from cancer prematurely; however, the cancer-specific needs of SGM people are under-reported and therefore under-studied. Our preliminary data reveals that oncology clinicians’ reluctance to ask about sexual orientation and gender identity is a root cause for the lack of systematic collection of SOGI information. This R03 application will enable the principal investigator to refine a concise, innovative training module for oncology clinicians focused on why and how to ask about patient sexual orientation and gender identity in cancer clinics, based directly upon formative clinician and SGM patient feedback, with an ultimate goal to improve affirming cancer care for SGM people.

PI_NAMEs: CATHCART-RAKE, ELIZABETH  (contact)

PROGRAM_OFFICER_NAME: SARMA, ELIZABETH ANNE

PROJECT_TERMS: Advanced Malignant Neoplasm;asexual;Attitude;cancer care;cancer diagnosis;Cancer Patient;Caring;Cessation of life;Clinic;clinic ready;Clinical;clinical practice;clinical research site;Clinical Trials;Code;Collection;Community Clinical Oncology Program;comparative;Competence;cultural competence;Data;Data Reporting;Death Rate;design;Development;Diagnosis;Disparity;Educational Curriculum;Educational process of instructing;Elements;end of life care;Equity;experience;Face;Feedback;Feeling;Gender Identity;gender minority;gender minority group;genderqueer;Goals;Health;health care delivery;health care service;Health Personnel;Healthcare;improved;Incidence;Individual;innovation;insight;Interview;Knowledge;Learning;Learning Module;Lesbian Gay Bisexual Transgender;Long-Term Care;Malignant Neoplasms;minority patient;Modeling;Oncologist;Oncology;Participant;Patients;Persons;Population;premature;Principal Investigator;Process;Qualitative Methods;Recommendation;recruit;Research;Research Personnel;response;Screening for cancer;Series;Sex Orientation;Sexual and Gender Minorities;sexual minority;sexual minority group;Shapes;Site;Structure;Testing;Training;Training Activity;United States;Update

PROJECT_TITLE: Refinement of a Training Module to Improve Discussions of Sexual Orientation and Gender Identity in Cancer Clinics

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-2 (J2)]


NIH_SPENDING_CATS: Anorexia;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Disability Research;Eating Disorders;Mental Health;Mental Illness;Neurosciences;Nutrition;Physical Activity;Prevention;Women's Health Research

ORG_CITY: PHILADELPHIA

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

PHR: Project Narrative Anorexia nervosa (AN) is a lethal psychiatric disease that disproportionately affects female-identified individuals and has high relapse rates (~35-41%), leading to chronic comorbidities and lifelong disability. Despite recent findings that AN susceptibility can be linked to genetic and metabolic factors, the neurobiology coordinating the preference and motivational drive for a starved rather than sated state is not well studied. The proposed research will examine the mechanisms used by hunger-promoting hypothalamic neurons that promote bodyweight gain in an animal model of AN using a combination of knock-in mouse models, and circuit-based behavioral neuroscience approaches.

PI_NAMEs: SUTTON HICKEY, AMES K (contact)

PROGRAM_OFFICER_NAME: FERNANDEZ, FERNANDO R

PROJECT_TERMS: Acute;Address;Affect;Animal Behavior;Animal Model;Animals;Anorexia;Anorexia Nervosa;Automobile Driving;Behavior;Behavioral;behavioral outcome;Behavioral Paradigm;behavioral response;Biological;Body Weight;Body Weight decreased;Brain;Cells;Cessation of life;Chronic;Chronic disability;comorbidity;Complex;Death Rate;Desire for food;disability;Disease;Disproportionately impacts women;dysphoria;Eating;Exercise;experience;experimental study;feeding;Feeding behaviors;Female;Fiber;Food;Food Access;food consumption;Food deprivation (experimental);Genetic;Goals;Human;Hunger;Hyperactive behavior;Hyperactivity;Hypothalamic structure;improved;in vivo;Individual;Knock-in Mouse;Lateral;Lifelong disability;Link;long term hospitalization;maladaptive behavior;Malnutrition;Maps;marginalization;Measures;Mediating;Medical;medical complication;Mental disorders;Metabolic;Monitor;Motivation;mouse model;Mus;Nature;neural;neurobiological mechanism;Neurobiology;Neurons;Neurosciences;opioid use disorder;optogenetics;Patients;Peptides;pharmacologic;Phenotype;Photometry;Physical activity;Population;Positive Valence;Predisposition;preference;Quality of life;reduced food intake;Relapse;Research;Research Personnel;Rodent;Rodent Model;Role;Running;Starvation;success;Suicide;Survival Rate;Technology;Testing;therapeutic target;trait;United States;Weight Gain;Work

PROJECT_TITLE: Elucidating the mechanisms employed by Agouti-related peptide neurons to decrease activity-based anorexia behavior in mice

STUDY_SECTION: PMDA

STUDY_SECTION_NAME: Pathophysiological Basis of Mental Disorders and Addictions Study Section[PMDA]


NIH_SPENDING_CATS: Bioengineering;Eye Disease and Disorders of Vision

ORG_CITY: AMHERST

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

PHR: Project Narrative The cornea is the transparent, outermost layer of the eye. Disease can cause the cornea to become cloudy, resulting in vision loss. We aim to use experimental data and computer modeling to understand the complex functional interactions between three membrane-transport proteins MCT1, NBCe1, and SLC4A11. This multidisciplinary project will provide new insights about corneal function and how NBCe1 and SLC4A11 mutations cause vision loss.

PI_NAMEs: OCCHIPINTI, ROSSANA ;PARKER, MARK  (contact)

PROGRAM_OFFICER_NAME: MCKIE, GEORGE ANN

PROJECT_TERMS: Acids;Anions;Automobile Driving;base;Bicarbonates;Blindness;Carbonates;Carrier Proteins;Cell model;Complex;Computer Models;Computers;Cornea;Corneal dystrophy;Corneal edema;Corneal Endothelium;Coupled;Data;Data Analyses;data modeling;Dependence;Descemet's membrane;Disease;disease-causing mutation;driving force;Electrophysiology (science);Endothelial Cells;Equilibrium;experimental study;Eye;falls;Fuchs' Endothelial Dystrophy;future implementation;Hydration status;in silico;In Vitro;insight;interdisciplinary approach;Intuition;Ions;Kinetics;Lactate Transporter;Liquid substance;Literature;mathematical model;Measures;Mediating;Membrane Proteins;Membrane Transport Proteins;Modeling;multidisciplinary;mutant;Mutation;Oocytes;Pathway interactions;Physiology;prevent;protein expression;Proteins;Pump;Research Personnel;symporter;System;Testing;tool;Training;Update;Validation;virtual;Xenopus oocyte

PROJECT_TITLE: Modeling and testing functional interactions among corneal endothelial acid-base transporters

STUDY_SECTION: BDE

STUDY_SECTION_NAME: Biology and Development of the Eye Study Section[BDE]


NIH_SPENDING_CATS: Aging;Bioengineering;Eye Disease and Disorders of Vision;Lymphatic Research;Neurodegenerative;Neurosciences

PHR: PROJECT NARRATIVE Glaucoma is a blinding disease that affects millions of people worldwide, but the underlying mechanisms are incompletely understood. This stems, in part, from a lack of model systems that accurately replicate the fluid drainage tissues responsible for intraocular pressure regulation. This work seeks to engineer a novel tissue platform that faithfully models the complex architecture and function of the outflow tract to facilitate improved investigations of glaucoma causes for identification of potential cures in the future.

PI_NAMEs: HERBERG, SAMUEL  (contact)

PROJECT_TERMS: 3-Dimensional;Actomyosin;Address;Affect;aqueous;Aqueous Humor;Architecture;Basal lamina;Benchmarking;Biochemical;Biological Assay;Biological Models;Biomedical Engineering;Biomimetics;cell behavior;Cell Communication;Cells;Cellular biology;Cellular Morphology;Clinical;Complex;Confocal Microscopy;Cornea;Custom;Cytoskeletal Modeling;Cytoskeleton;Data;design;Development;digital;Disease;Drainage procedure;Dyes;Elasticity;Encapsulated;Endothelial Cells;Endothelium;Engineering;Exhibits;experience;Extracellular Matrix;Failure;fluid flow;Focal Adhesions;Functional disorder;Future;Generations;Glaucoma;Goals;Health;Human;Hydrogels;Impairment;improved;In Situ;In Vitro;in vivo;Individual;innovation;Intercellular Fluid;Investigation;Label;Lasers;Light;Liquid substance;live cell imaging;Measurement;Mediating;Microfluidic Microchips;Modeling;Molecular;novel;Pathway interactions;Pattern;Perfusion;Periodicity;Persons;Phenotype;Physiologic Intraocular Pressure;Physiologic pulse;Positioning Attribute;pressure;Regulation;Resistance;resistance mechanism;Resolution;response;Soman;Stains;stem;Stimulus;stressor;Stretching;Structure;Structure of sinus venosus of sclera;System;Testing;Therapeutic;three dimensional cell culture;Time;Tissue Model;Tissues;tool;Trabecular meshwork structure;Tracer;Transforming Growth Factor Beta 2;Vacuole;Vision;Work

PROJECT_TITLE: TM/SC-interface-on-a-chip for mechanistic studies of outflow regulation.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-P (81)]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Autoimmune Disease;Digestive Diseases;Infectious Diseases;Inflammatory Bowel Disease;Microbiome;Prevention;Substance Misuse;Substance Misuse Prevention

ORG_CITY: MAYWOOD

ORG_DEPT: SURGERY

ORG_NAME: LOYOLA UNIVERSITY CHICAGO

PHR: Project Narrative Alcohol use has been suggested to induce and exacerbate flare periods and the pathology in patients suffering from colitis. Our studies are designed to examine the mechanisms by which alcohol worsens the flare periods. These studies are likely to help in developing new therapeutic strategies to maintain gut homeostasis and protect it from alcohol mediated exacerbation of symptoms associated colitis.

PI_NAMEs: CHOUDHRY, MASHKOOR A (contact)

PROGRAM_OFFICER_NAME: WANG, JOE

PROJECT_TERMS: Age;Alcohol consumption;alcohol exposure;alcohol prevention;Alcohols;Antibiotics;associated symptom;Bacteria;Clinical;Colitis;Colon;Consumption;cytokine;Defense Mechanisms;Demographic Accounting;design;dextran sulfate sodium induced colitis;Diagnosis;Disease;dysbiosis;effective therapy;Energy-Generating Resources;enteric infection;Enterobacteriaceae;Epithelial Cells;Ethanol;Feces;Flare;gastrointestinal;Genetic Transcription;Goals;gut bacteria;gut homeostasis;gut inflammation;Gut Mucosa;Impairment;Infiltration;Inflammation;Inflammatory;insight;interleukin-22;intestinal barrier;intestinal epithelium;Intestines;Laboratories;Lactobacillus;Large Intestine;Liver diseases;Maintenance;Mediating;mouse model;Mucous body substance;Mucous Membrane;Mus;Nervous System Disorder;Nitrates;Nitric Oxide;Nitric Oxide Synthase;novel therapeutic intervention;Pathogenicity;Pathology;Pathway interactions;Patients;Penetration;Phase;Phosphorylation;Play;Process;Reactive Oxygen Species;repaired;Reporting;Risk Factors;Role;Signal Transduction;Sodium Dextran Sulfate;STAT3 gene;Symptoms;Testing;Therapeutic;Tissues;Ulcerative Colitis;Up-Regulation

PROJECT_TITLE: IL-22-STAT3-Nos2 axis in alcohol-mediated exacerbation of UC pathology

STUDY_SECTION: AA

STUDY_SECTION_NAME: Biomedical Research Study Section[AA-1]


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Women's Health Research

ORG_CITY: OKLAHOMA CITY

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PHR: PROJECT NARRATIVE – ROLE OF JMJD4 IN BREAST CANCER Breast cancer constitutes the second most lethal malignancy for women in the US, indicating the dire need to develop novel efficacious therapies. Our research will elucidate how the JMJD4 enzyme facilitates the development of this disease. This may also nominate JMJD4 as a potential novel target for therapy in breast cancer.

PI_NAMEs: JANKNECHT, RALF  (contact)

PROGRAM_OFFICER_NAME: CERO, CHERYL

PROJECT_TERMS: 2-Oxoglutarate 5-Dioxygenase Procollagen-Lysine;Ablation;Affect;Binding;biological adaptation to stress;Breast;Breast Cancer Cell;Breast Cancer cell line;Breast Cancer Treatment;breast tumorigenesis;Cancer Etiology;cancer therapy;Cell Therapy;Cells;Cellular Stress;Chemoresistance;Colon Carcinoma;Data;demethylation;design;Development;Disease;Down-Regulation;Doxorubicin;driving force;efficacious treatment;Enzymes;ERBB2 gene;Estrogen receptor positive;Growth;Human;Hydroxylation;Hypoxia;In Vitro;in vivo;insight;Invaded;Knowledge;Lysine;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant Neoplasms;Mammary Neoplasms;Mediator;migration;Molecular;new therapeutic target;Normal Cell;novel;Oncogenic;overexpression;Oxidation-Reduction;Paclitaxel;Pathway interactions;Patients;Physiological;Physiology;Play;Proliferating;promoter;Proteins;Research;response;Role;Seminal;side effect;small molecule inhibitor;Stress;T47D;Testing;Therapeutic;Therapeutic Intervention;transcription factor;tumor;United States;Woman;Women's mortality;Xenograft procedure

PROJECT_TITLE: Role of JMJD4 in Breast Cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-A (J1)]


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Lung Cancer;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative  The poor survival rate of African Americans (AA) in lung cancer underscores insights into molecules responsible for the oncogenic progression of benign pulmonary nodules in AA. We identified an AA-specific pfeRNA following the requirements of a CLIA-compliant LDT and will provide mechanistic rationale and therapeutic insights into this druggable pfeRNA. The project will provide a new opportunity to reduce racial and ethnic health disparities in AA with NSCLC.

PI_NAMEs: MEI, YUPING  (contact)

PROGRAM_OFFICER_NAME: WALLACE, TIFFANY A

PROJECT_TERMS: Address;African American;African American population;Animal Model;aptamer;Asian population;Benign;Bioinformatics;Biological;Biological Assay;Biometry;Biopsy;cancer therapy;Cancerous;Caucasians;Cells;Certification;Chemicals;Clinical;Clinical Laboratory Improvement Amendments;Collaborations;Death Rate;deep sequencing;design;Development;differential expression;DNA Sequence Alteration;efficacy evaluation;Elements;ethnic health disparity;Ethnic Origin;Ethnic Population;Evolution;Exposure to;FDA approved;Fluorescence Resonance Energy Transfer;health disparity;Immunoprecipitation;Incidence;innovation;insight;interest;Laboratories;Ligation;Liquid Chromatography;Low Prevalence;Lung;Lung nodule;Malignant - descriptor;Malignant neoplasm of lung;Malignant Neoplasms;Modeling;Modification;mutant;Mutation;Neoplasms;Non-Small-Cell Lung Carcinoma;Normal tissue morphology;novel;Nude Mice;Oligonucleotides;Oncogenic;Outcome;Pathway interactions;patient derived xenograft model;Patients;Pattern;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;Plasmids;pre-clinical;preclinical development;prevent;Proteins;racial health disparity;racial population;Research;Research Personnel;Safety;Smoking;Solid;Specific qualifier value;Specimen;Survival Rate;System;tandem mass spectrometry;Testing;Therapeutic;therapeutic target;Tissues;transcription factor;transcriptome;Translating;Untranslated RNA

PROJECT_TITLE: Ethnicity-driven pfeRNA in African American health disparities in lung cancer.


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Prevention;Prostate Cancer;Urologic Diseases

ORG_CITY: COLUMBIA

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

ORG_STATE: MO

PHR: Project Narrative This project will design and tailor interventions and develop plans for a large-scale trial to test these interventions to implement high quality active surveillance among men with favorable-risk prostate cancer. By identifying interventions to improve the quality of active surveillance, we will ensure its sustainability and protect against avoidable cancer morbidity. By focusing on scalable interventions, we will ensure that those developed can be implemented across large population groups.

PI_NAMEs: HOLLENBECK, BRENT K.;SALES, ANNE EVELYN (contact);SHAHINIAN, VAHAKN B

PROGRAM_OFFICER_NAME: CHOLLETTE, VERONICA

PROJECT_TERMS: Adherence;Adoption;cancer initiation;Caring;Characteristics;chemotherapy;Chronic Disease;clinical practice;Clinical Trials;cost;Coupled;curative treatments;Dangerousness;Data;Data Reporting;design;Development;Diagnosis;Disease;Early Diagnosis;Ensure;Equilibrium;evidence base;Feedback;Functional disorder;Future;Goals;Guideline Adherence;Guidelines;Heterogeneity;implementation determinants;implementation intervention;improved;Indolent;Intervention;Interview;Intestines;Literature;Magnetic Resonance Imaging;Malignant neoplasm of prostate;Malignant Neoplasms;men;Michigan;Monitor;Morbidity - disease rate;mortality;National Comprehensive Cancer Network;Newly Diagnosed;Operative Surgical Procedures;Patient Selection;Patients;Population;Population Group;prostate biopsy;prostate cancer risk;Provider;Publishing;Radiation therapy;Registries;Research;Risk;Rural;screening;Severities;side effect;Site;Structure;surveillance network;Surveys;Testing;Time;tumor;tumor progression;urinary;urologic;Urologic Surgical Procedures;Urologist;Urology;Variant;Work

PROJECT_TITLE: Planning to implement high-quality active surveillance in new-onset favorable risk prostate cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 TCRB-J (J1)]