ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Cancer;Natural Products;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: Project narrative The supplement grant is to request the support for Mr. Emanuel Baltrip, a graduate student of African American, to pursue his Ph.D. training. In research aspect, he will work on his dissertation project, a part of the parent funded parent project (1R01CA257842-01A1) on developing polymeric micelle delivery of paclitaxel and cyclopamine for the treatment of hepatocellular adenocarcinoma (HCC) in orthotopic mouse models. In mentoring and career development aspect, Mr. Baltrip will be trained in developing research skills in hypothesis development, experimental study planning and execution, critical data analysis, and verbal and written communication skills, as well as developing proposals, to acquire a comprehensive set of skills for becoming a conscientious and capable cancer researcher of the underrepresented ethnicity, to fulfill the unmet clinical need for improving the survival and quality of life of HCC patients.

PI_NAMEs: CHOW, DIANA S-L.;LI, CHUN  (contact)

PROGRAM_OFFICER_NAME: FU, YALI

PROJECT_TERMS: Adenocarcinoma;Adverse event;African-American Graduate Student;Animals;Apoptosis;Biodistribution;biomarker development;c-myc Genes;cancer cell;cancer stem cell;cancer type;career development;chemotherapeutic agent;chemotherapy;Clinic;Clinical;Clinical Pathways;clinical risk;clinical translation;Combined Modality Therapy;Communication;cyclopamine;cytotoxic;Data Analyses;Derivation procedure;Development;Distant;Doctor of Philosophy;Dose;Drug Kinetics;drug metabolism;Drug resistance;effective therapy;epithelial to mesenchymal transition;Ethnic Origin;experimental study;Extracellular Matrix;Female;Funding;Goals;Grant;improved;inhibitor;innovation;insight;male;Malignant Neoplasms;Measures;Mentors;Micelles;Mitosis;Monitor;mouse model;Multi-Drug Resistance;Mus;Neoplasm Metastasis;neoplastic cell;Organ;Paclitaxel;parent project;Parents;Patients;Pharmaceutical Preparations;pharmacodynamic biomarker;Pharmacodynamics;pharmacokinetics and pharmacodynamics;pharmacologic;Plasma;Play;Polymers;Pre-Clinical Model;Prevalence;Preventive;Primary carcinoma of the liver cells;Proliferating;Quality of life;Recurrence;Research;Research Personnel;Resistance;Role;scale up;self-renewal;sex;Site;skills;smoothened signaling pathway;spheroids;System;Systemic Therapy;Technology;Testing;Therapeutic;Toxic effect;Training;Transgenic Mice;Translating;Treatment Efficacy;treatment response;tumor;tumor growth;tumor initiation;Tumor Stem Cells;verbal;Work;Writing;α-Fetoproteins

PROJECT_TITLE: Pre-IND Development of Polymeric Micelles with Dual Drug Payloads for HCC Therapy


ADMINISTERING_IC: MH

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Mental Health;Mental Illness;Pediatric;Suicide

ORG_CITY: PROVIDENCE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PSYCHIATRY

ORG_FIPS: US

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: PROJECT NARRATIVE This project is designed to study suicidal thoughts and behavior in a sample of young children, 8 to 11 years old, who are being treated for emotional and behavioral difficulties. The goal of the study is to better understand suicidal thoughts and behavior in preteen children. Specifically, if these thoughts and behaviors lead to future suicidal thoughts and behavior and psychiatric care over a 12-month follow-up period.

PI_NAMEs: SPIRITO, ANTHONY  (contact);WOLFF, JENNIFER CHRISTINE

PROGRAM_OFFICER_NAME: GARVEY, MARJORIE ANN

PROJECT_TERMS: 11 year old;Address;Affect;age group;Assessment tool;associated symptom;Behavior;Behavior assessment;Behavioral;behavioral outcome;Biological Markers;Cessation of life;Child;Clinical;Clinical assessments;clinical practice;cognitive capacity;critical period;Day Care;design;Development;emotion regulation;Emotional;Ensure;experience;Failure;Feeling suicidal;follow-up;Future;Goals;high risk population;Hospitals;Implicit Association Test;improved;informant;innovation;Inpatients;Interview;Lead;Measures;medical schools;Mental disorders;multimodality;National Institute of Mental Health;Onset of illness;Parents;Patient Self-Report;Population Heterogeneity;preadolescence;protective factors;Psychiatric therapeutic procedure;recruit;Research;Research Domain Criteria;resilience;Risk;Risk Factors;Sampling;Series;Services;suicidal behavior;Suicide;symptomatology;Symptoms;Teenagers;Testing;Thinking;Time;Work;Youth

PROJECT_TITLE: Towards a reliable and valid assessment of preteen suicidal thoughts and behavior


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Genetics;Human Genome;Mental Health;Neurodegenerative;Neurosciences;Women's Health Research

ORG_CITY: SEATTLE

ORG_NAME: ALLEN INSTITUTE

ORG_STATE: WA

PHR: Narrative: The goal of this supplement is to characterize how sex and age pattern cellular and molecular differences in the macaque entorhinal cortex. To do so, we are generating single nucleus (sn)RNA-seq data from the entorhinal cortices of 135 macaques, including 77 females, spanning the natural lifespan of free-living macaques. Graduate student Kelsi Watkins will receive training in computational, statistical, and theoretical analysis of large-scale snRNA-seq data, directly supporting the parent grant's objectives to uncover factors influencing cellular variability and to understand the biology behind the female bias in Alzheimer's Disease diagnoses.

PI_NAMEs: LEIN, ED  (contact);ZENG, HONGKUI

PROGRAM_OFFICER_NAME: YAO, YONG

PROJECT_TERMS: Address;Adult;Affect;Age;Aging;Alzheimer's Disease;Alzheimer's disease diagnosis;Atlases;Bioinformatics;Biology;Biology of Aging;brain cell;Brain region;career;career development;cell type;Data;Data Analyses;Demographic Factors;Demographic Impact;Development;Disease;Disproportionately impacts women;entorhinal cortex;Etiology;experience;Female;Gene Expression;gene regulatory network;Genetic Transcription;Goals;graduate student;Heterogeneity;Hippocampus;Human;insight;Investigation;life span;Macaca;memory retrieval;Mentorship;Molecular;Neocortex;neurogenomics;next generation;parent grant;Pattern;Population;Postdoctoral Fellow;pre-doctoral;Prevalence;Public Speaking;Research;Research Personnel;sex;single cell genomics;single nucleus RNA-sequencing;skills;spatial memory;Structure;Time Perception;Training;Variant;Writing

PROJECT_TITLE: Functionally guided adult whole brain cell atlas in human and NHP


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Genetics;Human Genome;Prevention;Social Determinants of Health

ORG_CITY: DURHAM

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Public Health Relevance Despite evidence of its clinical importance, family health history (FHH) is broadly under-utilized and under-appreciated, due in large part on patients’ ability and willingness to discuss FHH. This proposal aims to explore patients’ culture, age and gender, and other factors that likely impact FHH knowledge and sharing. These data will inform revisions to the FHH tool and development of educational resources to promote more complete data collection.

PI_NAMEs: ORLANDO, LORI ANN (contact)

PROGRAM_OFFICER_NAME: RIDER, RENEE ANNE

PROJECT_TERMS: Age;age difference;Assessment tool;Award;Caring;cascade genetic testing;Clinical;clinical care;Collection;Communities;Computer software;Cultural Diversity;Data;Data Collection;demographics;Development;Disclosure;education resources;educational resource development;Ethnic Origin;Family;Family health status;Family member;family structure;Feedback;flexibility;Gender;gender difference;genetic testing;Genomic medicine;Goals;Health;Health Personnel;Health Status;hereditary risk;improved;Infrastructure;Intake;Interview;Knowledge;Learning;Lesbian Gay Bisexual Transgender Queer;lifestyle factors;literacy;Meta-Analysis;Modeling;Older Population;older women;parent project;participant enrollment;Patient Participation;patient population;patient-level barriers;Patients;Perception;programs;Provider;public health relevance;Race;Recording of previous events;Reporting;Review Literature;Risk;Risk Assessment;Risk Management;Series;Service delivery model;Social Network;Software Tools;Structure;System;systematic review;Test Result;Testing;tool;willingness

PROJECT_TITLE: Assessing Impact of Cultural Diversity and Family Health History


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Data Science;Disability Research;Lung;Lung Cancer;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Social Determinants of Health

ORG_CITY: Newark

ORG_DEPT: BIOLOGY

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because the development and better utilization novel machine learning for classifying non-cancer deaths in cancer patients with disabilities is expected to reduce the morbidity and mortality in these patients. Thus, the proposed research is relevant to the part of the NIH’s mission that pertains to developing fundamental knowledge that will help to lengthen human lives and reduce the burdens of human illness.

PI_NAMEs: ZHANG, LANJING  (contact)

PROGRAM_OFFICER_NAME: JENSEN, ROXANNE ELAINE

PROJECT_TERMS: Address;Algorithms;Area;Awareness;Breast Cancer Patient;cancer care;cancer cell;cancer diagnosis;Cancer Patient;career;Categories;Cessation of life;Collaborations;Colorectal Cancer;Creativeness;Data;Data Science;Data Set;Development;disability;Economic Burden;Educational process of instructing;explainable machine learning;Extramural Activities;Foundations;Goals;Grant;health disparity;high school;Human;improved;interdisciplinary collaboration;Knowledge;Label;Learning;machine learning classification;Malignant neoplasm of cervix uteri;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant Neoplasms;Medicare;Methods;Minority Groups;Mission;Modeling;Morbidity - disease rate;mortality;novel;parent grant;Patients;Performance;Physicians;Population;Problem Solving;prognostication;programs;Public Health;Reporting;Research;Research Personnel;Risk;Schools;screening;SMART health;socioeconomics;Solid;Students;Survival Rate;Technology;Time;tool;undergraduate student;Underrepresented Students;United States National Institutes of Health;Universities;Validation;Work

PROJECT_TITLE: Screening and confirmatory machine learning for explainable modeling of non-cancer deaths in cancer patients

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(50)-R]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_DEPT: ORTHOPEDICS

PHR: Project Narrative Heart Failure with reduced ejection fraction (HFrEF) affects millions of people and weakness of the diaphragm muscle that is used to breathe. Diaphragm weakness, caused by muscle atrophy and contractile dysfunction, impaired metabolism, and exercise intolerance are significant problems in patients because it contributes to morbidity and mortality. Our goal is to gain a deeper understanding of mechanisms and identify targets for prevention and treatment of diaphragm weakness in HFrEF.

PI_NAMEs: FERREIRA, LEONARDO  (contact)

PROGRAM_OFFICER_NAME: POIZAT, CORALIE ISABELLE

PROJECT_TERMS: Actins;Actomyosin Adenosinetriphosphatase;Affect;Aging;Alveolar;Animals;Arrhythmia;ATP phosphohydrolase;Atrophic;Award;Biochemistry;Biogenesis;Biophysics;Breathing;career;career development;Cells;Cellular biology;Clinical Research;Congestive Heart Failure;Coughing;Cysteine;Degradation Pathway;Exercise;exercise capacity;exercise intolerance;Exercise Tolerance;experimental study;Fatigue;Fiber;Fluorometry;Freezing;Functional disorder;Genetic Transcription;Goals;Health;Heart failure;heart failure with reduced ejection fraction;Hydrogen Peroxide;Impairment;improved;In Vitro;insight;Intervention;Isometric Exercise;Isotonic Exercise;Lead;Macrophage;Measurement;Measures;Mediating;member;Mentors;Mentorship;Metabolic;Metabolism;Methionine;methionine sulfoxide reductase;mid-career faculty;Mitochondria;mitochondrial dysfunction;Modification;Morbidity - disease rate;mortality;mRNA Expression;Muscle;Muscle Cells;Muscle Fibers;muscle physiology;Muscular Atrophy;overexpression;oxidation;Oxidation-Reduction;Oxidative Stress Induction;Oxidoreductase;parent grant;parent project;Patients;Peripheral;Permeability;Persons;Phenotype;Pneumonia;Preparation;prevent;Prevention;Procedures;Process;Production;Property;Protein Biosynthesis;protein expression;Proteins;Proteomics;Quality Control;Reactive Oxygen Species;Regulation;Research;research and development;Research Personnel;Resolution;Respiration;Respiratory Diaphragm;Respiratory Muscles;Ribosomal Proteins;Ribosomal RNA;Ribosomes;Role;Running;Sampling;senior faculty;Shortness of Breath;Signal Transduction;Signaling Protein;Spirometry;Sulfhydryl Compounds;Supervision;Sympathetic Nervous System;Testing;Tissues;Training;Translational Research;translational study;Triton;vasoconstriction;vector;ventilation;VO2max

PROJECT_TITLE: Redox basis of diaphragm mitochondrial dysfunction and atrophy in heart failure

STUDY_SECTION: SMEP

STUDY_SECTION_NAME: Skeletal Muscle and Exercise Physiology Study Section[SMEP]


NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Precision Medicine;Serious Mental Illness

ORG_CITY: BELMONT

ORG_NAME: MCLEAN HOSPITAL

ORG_STATE: MA

PHR: Project Narrative Exposure therapy is the most effective treatment available for obsessive compulsive disorder, yet up to 50% of patients fail to recover because we do not understand the mechanisms underlying successful response, leading to significant variability in how clinicians conduct exposure therapy. Using machine learning to analyze patient data from real-world treatment, the current study will determine which exposure mechanisms lead to favorable clinical outcomes and what makes a good exposure for whom. Results of this study have the potential to improve personalized care for the many patients who do not remit following exposure therapy for OCD.

PI_NAMEs: KUCKERTZ, JENNIE M (contact)

PROGRAM_OFFICER_NAME: TALKOVSKY, ALEXANDER MAXWELL

PROJECT_TERMS: Adult;anxiety sensitivity;Behavior;Caring;Characteristics;Clinical;Continuity of Patient Care;Data;effective therapy;Exposure to;Favorable Clinical Outcome;Feedback;Future;Galvanic Skin Response;Goals;habituation;Heart Rate;heart rate variability;Hospitals;improved;Individual;innovation;insight;Lead;Learning;learning outcome;Left;Machine Learning;Measures;Mental Depression;Methods;Modeling;National Institute of Mental Health;Obsessive-Compulsive Disorder;Outcome;Outpatients;Participant;Patient Self-Report;Patient-Focused Outcomes;Patients;Performance;personalized care;personalized intervention;personalized medicine;Persons;Physiological;Physiology;Pilot Projects;predictive modeling;Reporting;Research;response;Self Efficacy;sexual minority;Site;Symptoms;Testing;Theoretical model;theories;therapeutic target;Translating;Treatment Failure;treatment response;Universities;wearable device;Work

PROJECT_TITLE: Admin Supplement: Leveraging Machine Learning Approaches to Understand Mechanisms of Exposure Therapy in Real-World Settings


ADMINISTERING_IC: GM

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Building Research Capacity at Institutions with Limited NIH Funding;Eye Disease and Disorders of Vision;Neurosciences;Precision Medicine

ORG_CITY: NEW ORLEANS

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PI_NAMEs: KROUSEL-WOOD, MARIE ;MONDRINOS, MARK  (contact)

PROGRAM_OFFICER_NAME: PEI, WUHONG

PROJECT_TERMS: Androgens;angiogenesis;Bioenergetics;Biological Assay;Biological Models;Biomedical Engineering;candidate identification;candidate marker;Cardiovascular system;Cell Culture System;Cells;Centers of Research Excellence;cytokine;Diabetic Retinopathy;Elements;Endothelium;Environment;Estrogens;Functional disorder;Gender;gender affirming hormone therapy;Goals;Gonadal Steroid Hormones;hormone regulation;Hormones;Human;human disease;human model;Inflammatory;insight;Investigation;Methods;microphysiology system;microvascular pathology;Modeling;novel;Pathologic Neovascularization;Physiological;precision medicine;Process;Reporting;Research;response;Retina;screening;sex;single-cell RNA sequencing;Stimulus;System;Therapeutic;three dimensional cell culture;transcriptomics;Vascular Endothelial Growth Factors;Vascular Permeabilities;Vasculogenic

PROJECT_TITLE: Bioengineering Microphysiological Models of Sex-Specific Pathophysiology

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 RCB-3 (C1)]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Neurosciences;Psychosis;Schizophrenia;Serious Mental Illness

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PI_NAMEs: SHEFFIELD, JULIA MAY (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: Academic Medical Centers;Acute;Address;Administrative Supplement;arm;Award;Behavior;Behavioral Sciences;Belief;Birth;Brain;career;career development;Child;Childbirth;clinical translation;Cognitive;cognitive neuroscience;cognitive task;cohort;comparison group;computational neuroscience;Computer Models;Corpus striatum structure;Cross-Sectional Studies;Data;Data Analyses;Data Collection;debilitating symptom;Delusions;Development;Development Plans;Diagnostic;Dimensions;emotional distress;Event;expectation;experience;flexibility;Functional impairment;Functional Magnetic Resonance Imaging;Funding;Future;Goals;Hospitalization;ideation;improved;Individual;Inpatients;Intervention;Intervention Studies;K-Series Research Career Programs;Knowledge;Life;longitudinal course;Maintenance;Measurement;Measures;Mediating;Mediation;Mentors;Methods;Modeling;Neurobiology;Neurocognitive;neuroimaging;novel;Outpatients;parent project;Parental Leave;Participant;patient oriented;Patients;Persons;Population;Prefrontal Cortex;Process;professor;programs;Psychiatric Hospitals;Psychiatry;Psychoses;psychotic;Psychotic Disorders;psychotic symptoms;Quality of life;Recovery;recruit;Research;research and development;Research Assistant;Research Design;Research Personnel;Resistance;Resources;response;Role;Schizophrenia;Scientist;Sensory;Severities;skills;statistics;Symptoms;Techniques;Testing;theories;therapy development;Thinking;Time;timeline;Training;trait;Translational Research;Uncertainty;Update;Ventral Striatum;Violence;Work

PROJECT_TITLE: Cognitive mechanisms of delusion severity throughout recovery from a psychotic episode: a computational approach


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Building Research Capacity at Institutions with Limited NIH Funding;Emerging Infectious Diseases;Foodborne Illness;Infectious Diseases;Neurosciences

ORG_CITY: OKLAHOMA CITY

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PI_NAMEs: KENT, ROBYN STACEY (contact)

PROGRAM_OFFICER_NAME: CUPIT, PAULINE

PROJECT_TERMS: Applications Grants;Brain;Cells;Chronic;chronic infection;clinically relevant;Cyst;Data;Development;Eye;Functional disorder;Gene Expression Profiling;Goals;Health;Human;Immunity;In Vitro;Intervention;Maintenance;Methods;microbial;Mus;Muscle;Myocardium;Nervous System Disorder;novel therapeutics;Oklahoma;Organ;Parasites;Parasitic infection;Pathogenesis;Pathology;Pharmaceutical Preparations;Population;response;Risk;Set protein;Skeletal Muscle;Testing;Tissues;Toxoplasma gondii;Toxoplasmosis;transcriptomics;Work

PROJECT_TITLE: Elucidating tissue specific requirements for - and responses to - a chronic T. gondii infection


ORG_CITY: OMAHA

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: No changes from the Parent (CA275846)

PI_NAMEs: BERGAN, RAYMOND C. (contact);NATARAJAN, AMARNATH (AMAR)

PROGRAM_OFFICER_NAME: CLIFFORD, JOHN LEO

PROJECT_TERMS: extracellular;Parents;Peptide Hydrolases;Phenotype;prostate cancer progression;Regulation

PROJECT_TITLE: Regulation of extracellular proteases in prostate cancer progression to a metastatic phenotype

STUDY_SECTION: CPSS

STUDY_SECTION_NAME: Cancer Prevention Study Section[CPSS]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Neurosciences;Palliative Care;Racial and Ethnic Minority Health Research

PHR: Project Narrative Integral to all aims of the parent grant (from here on, Human Mammalian Brain Atlas, or HMBA) is a hospice/palliative care brain donor program which will collect functional imaging data from participants antemortem to integrate with the whole brain atlas generated postmortem. Disparities in access to palliative and hospice care have the potential to disrupt HMBA's ability to meaningfully include and positively impact people from minoritized groups. This supplement will support post-baccalaureate researcher Zoë Hale as she designs a qualitative interview study to collect the perspectives of hospice and palliative care workers serving underrepresented minority groups.

PROJECT_TERMS: access disparities;Adult;Atlases;Autopsy;Bioethics;Brain;brain cell;career;Caring;Collaborations;Data;design;Disparity;Ethics;Ethnic Origin;Functional Imaging;Hexamethylene Bisacetamide;Hospice Care;hospice environment;Human;Humanities;Interview;minority communities;Minority Groups;Morals;Palliative Care;parent grant;Participant;Postbaccalaureate;programs;Qualitative Research;racial minority population;Research Personnel;Research Support;Review Literature;Science;Series;Training;Underrepresented Minority;United States National Institutes of Health


NIH_SPENDING_CATS: Brain Disorders;Cancer;Clinical Research;Immunotherapy;Skin Cancer

ORG_NAME: INSTITUTE FOR SYSTEMS BIOLOGY

PHR: Overall Narrative The proposed U54 program Spatiotemporal Tumor Analytics for Guiding Sequential Targeted-Inhibitor -- Immunotherapy Combinations (ST-Analytics) is designed to develop the recent conceptual advance that targeted inhibitor + cancer immunotherapy (IT) combination treatments may yield significantly greater patient benefit if those treatments are administered in sequence rather than as monotherapies or as simultaneously administered combinations.

PI_NAMEs: HEATH, JAMES R. (contact)

PROGRAM_OFFICER_NAME: ZAMISCH, MONICA

PROJECT_TERMS: Address;Adoptive Cell Transfers;Automobile Driving;Biopsy;Calibration;cancer immunotherapy;Clinical Data;Clinical Trials;Combination immunotherapy;combinatorial;Combined Modality Therapy;Communities;Coupled;Databases;design;Development;disease model;Distal;Dose;Education and Outreach;Immune;immune checkpoint blockade;Immunologic Factors;Immunotherapy;in silico;in vivo;inhibitor;inhibitor therapy;Kinetics;Lead;medical schools;Melanoma;Metastatic malignant neoplasm to brain;Mitogen-Activated Protein Kinase Inhibitor;Modeling;mouse model;Neoplasm Metastasis;Outcome;outreach;outreach program;Patients;Play;prevent;Primary Neoplasm;programs;Research;Research Project Grants;Resistance;Resources;Role;Science;Science, Technology, Engineering and Mathematics Education;Scientist;spatiotemporal;Structure;System;Therapeutic;tumor;Work

PROJECT_TITLE: Spatiotemporal Tumor Analytics for Guiding Sequential Targeted-Inhibitor: Immunotherapy Combinations (ST-Analytics)


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Neurosciences;Physical Injury - Accidents and Adverse Effects;Post-Traumatic Stress Disorder (PTSD);Serious Mental Illness;Social Determinants of Health;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: ALBUQUERQUE

ORG_NAME: LOVELACE BIOMEDICAL RESEARCH INSTITUTE

ORG_STATE: NM

PHR: Contact PD/PI: KIEHL, KENT A Project Narrative Forensic populations have a rate of traumatic brain injury many times higher than the general population. The parent R01 conducts follow-up exams with N=300 male and female offenders with varying history of brain injury. The R01 tests the ability of machine learning algorithms to predict brain injury and cognitive decline from multimodal neuroimaging data. This raises complex bioethical questions. Here we conduct bioethical inquiry and stakeholder analysis in vulnerable forensic populations regarding the complex issues surrounding Artificial Intelligence/Machine Learning diagnostics for TBI and use of advanced techniques for treatment of TBI in forensic populations.

PI_NAMEs: KIEHL, KENT A (contact);KOENIGS, MICHAEL R.

PROGRAM_OFFICER_NAME: UMOH, NSINI ALEASE

PROJECT_TERMS: Acute;addiction;Address;Administrative Supplement;Affect;Algorithms;Anxiety;Artificial Intelligence;Brain;Brain Diseases;Brain Injuries;Child;Clinical;Clinical Treatment;Clinical Trials;Cognitive;Communities;comorbidity;Complex;Consent;cost;court;Craniocerebral Trauma;Data;Diagnostic;Diagnostics Research;disability;Disadvantaged;Disinhibition;Emotional;Enrollment;Ethical Issues;Ethics;Facilities and Administrative Costs;Female;follow-up;Forensic Medicine;Future;General Population;Health;health care disparity;health disparity;Healthcare;high risk population;Human;Impaired cognition;Imprisonment;Incidence;Incidental Findings;Individual;Inequality;Inequity;Institutional Review Boards;interest;Left;Legal;Longitudinal Studies;Machine Learning;machine learning algorithm;machine learning classification;Magnetic Resonance Imaging;Major Depressive Disorder;male;Medical;Mental Depression;Mental Health;mild traumatic brain injury;Modeling;multimodal neuroimaging;National Institute of Neurological Disorders and Stroke;neural;neural circuit;Neurobiology;neuroimaging;Neurologic;neuroregulation;Neurosciences Research;Obsessive-Compulsive Disorder;offender;parent grant;Parents;Participant;Personality Disorders;Persons;Policies;Population;Post-Traumatic Stress Disorders;Prisons;Privacy;productivity loss;Psychopathology;Public Health;Published Comment;Recording of previous events;Records;Reporting;Research;Risk;Risk Assessment;Risk Factors;Sampling;Signs and Symptoms;Source;Substance abuse problem;substance use;Symptoms;TBI treatment;Techniques;Testing;Trauma;Traumatic Brain Injury;trial design;United States;United States National Institutes of Health;Vulnerable Populations;Work

PROJECT_TITLE: A longitudinal study of traumatic brain injury in a high-risk population

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Chronic Pain;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy;Physical Injury - Accidents and Adverse Effects;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: SAN FRANCISCO

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE Debilitating pain, a hallmark of tissue injury and neuropathy, is an unmet clinical challenge in heterotopic ossification (HO) that occurs following orthopedic surgery and traumatic injuries. With an aim at developing new strategies to manage injury-induced chronic pain and pathological HO, we will use novel preclinical models to elucidate the mechanisms downstream of active sensory neuron-specific ACVR1, mechanisms that may be shared by other chronic pain and musculoskeletal injury conditions.

PI_NAMEs: YU, XIAOBING  (contact)

PROGRAM_OFFICER_NAME: CHEN, FAYE H

PROJECT_TERMS: ACVR1 gene;Adult;Afferent Neurons;Axotomy;Biological Assay;bone;bone loss;bone morphogenetic protein receptor type I;Cells;chronic pain;Clinical;Connective Tissue;debilitating pain;effective therapy;gain of function;Genes;Heterotopic Ossification;Histidine;Homeostasis;Hyperactivity;Hypersensitivity;Immune;Immune response;Impairment;In Vitro;in vivo Model;induced pluripotent stem cell;Inflammatory;Inherited;inhibitor;Injury;insight;Intrathecal Injections;kinase inhibitor;Link;Macrophage;Mechanics;Modeling;Molecular;Molecular Target;mouse model;Mus;Muscle;Musculoskeletal Diseases;musculoskeletal injury;nerve injury;Neuroimmune;Neurons;Neuropathy;Neuropeptides;Nociception;Nociceptors;novel;novel strategies;novel therapeutic intervention;Orthopedic Surgery;Osteogenesis;Pain;pain model;painful neuropathy;Pathologic;patient derived induced pluripotent stem cells;Patients;Peripheral;Persistent pain;phase II trial;Physiologic Ossification;Point Mutation;pre-clinical;Pre-Clinical Model;prevent;progressive myositis ossificans;release factor;response;Signal Transduction;Site;small molecule;spared nerve;Spinal Ganglia;Surgical Injuries;Testing;Therapeutic;tissue injury;Tissues;transcriptomic profiling;transcriptomics;Transgenic Mice;Trauma;Traumatic injury

PROJECT_TITLE: ACVR1 sensory neuron-specific signaling in neuropathic pain and injury-induced heterotopic ossification

STUDY_SECTION: NPI

STUDY_SECTION_NAME: Neurobiology of Pain and Itch Study Section [NPI]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease

ORG_CITY: CHARLESTON

ORG_DEPT: SURGERY

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: PROJECT NARRATIVE This training program supports students pursuing the dual MD/PhD degree who will receive rigorous and directed training in the basic and clinical sciences and exposure to translation research. They are expected to be future academic physician-scientists able to conduct both basic and clinical/translational research. They will be capable of bridging the basic and clinical sciences in order to perform research at the cutting edge and become leaders in their respective fields.

PI_NAMEs: DEMORE, NANCY  (contact)

PROGRAM_OFFICER_NAME: KEANE-MYERS, ANDREA

PROJECT_TERMS: Medical;Scientist;Training Programs

PROJECT_TITLE: TRAINING PROGRAM FOR MEDICAL SCIENTISTS

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - A[TWD-A]


ADMINISTERING_IC: ES

FUNDING_MECHANISM: NON SBIR/STTR CONTRACTS

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Endocrine Disruptors;Foodborne Illness

ORG_CITY: FAIRFAX

ORG_NAME: CONSOLIDATED SAFETY SERVICES, INC.

ORG_STATE: VA

PI_NAMEs: BRECHER, STEVE  (contact)

PROJECT_TERMS: Address;Area;Attention;Chemicals;Communication;Contractor;Contracts;Data;data management;data sharing;Databases;Development;dietary supplements;Documentation;drinking water;Electronics;Generations;Health Sciences;Human Resources;improved;Industrialization;Laboratories;Manuscripts;Molds;Monograph;National Toxicology Program;Output;Pathology;Pesticides;phthalates;Plasticizers;Poly-fluoroalkyl substances;Process;Records;Reporting;Review Literature;System;Toxicology;United States National Institutes of Health;Validation;Water Pollutants;web site

PROJECT_TITLE: Quality Assessment Support


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Digestive Diseases;Hepatitis;Hepatitis - C;Infectious Diseases;Liver Disease

ORG_CITY: HADLEY

ORG_NAME: VENTUREWELL

PI_NAMEs: NEAL, REBEKAH ANNE (contact)

PROJECT_TERMS: Acceleration;Businesses;Clinical;commercialization;Communication;Complex;data management;Development;diagnostic technologies;Electronics;Evaluation;Funding;Goals;Hepatitis C virus;HIV;HIV/AIDS;Home;innovation;parallelization;point of care;Procedures;Process;programs;Progress Reports;RADx;Resources;risk mitigation;Schedule;Services;Speed;technology development;Testing;United States National Institutes of Health;Vendor;web site

PROJECT_TITLE: SUPPLEMENTAL FUNDS FOR RADX INDEPENDENT TEST ASSESSMENT PROGRAM FOR HEPATITIS C VIRUS - COMMERCIALIZATION CENTER


NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: SILVER SPRING

ORG_NAME: SOCIAL AND SCIENTIFIC SYSTEMS,  INC.

ORG_STATE: MD

PI_NAMEs: BARKOSKI, JACQUELINE  (contact)

PROJECT_TERMS: Acculturation;Bhutanese;Biological;Biological Markers;cardiometabolism;Cohort Studies;Communities;comorbidity;Data;design;Etiology;Feasibility Studies;Foundations;Health;Immigrant;minimally invasive;National Institute of Environmental Health Sciences;Ohio;Participant;Pathway interactions;Pilot Projects;Population;Prospective cohort;Questionnaires;Refugees;research and development;Role;Sampling;socioenvironmental factor;Specimen;Surveys;Urine;Whole Blood

PROJECT_TITLE: TO2R: RESEARCH DEVELOPMENT


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Climate-Related Exposures and Conditions;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: BOSTON

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

PHR: RELEVANCE (See instructions): The proposed research supports the National Institute of Environmental Health Sciences (NIEHS) mission to discover how the environment affects people to promote healthier lives through the lens of climate justice. The work will contribute to the NIEHS strategic plan for "Data Science and Big Data" by developing innovative data science and data-driven approaches overcoming analytical challenges in the

PI_NAMEs: DOMINICI, FRANCESCA  (contact);GARCIA TEC, MAURICIO

PROGRAM_OFFICER_NAME: CUI, YUXIA

PROJECT_TERMS: Accounting;Address;Affect;Air Pollution;Architecture;Behavioral;Big Data;Case Study;Cause of Death;Cessation of life;Climate;climate change;climate crisis;climate data;climate-related exposures;Collection;combinatorial;Communities;Complex;computer scientist;computerized data processing;Crime;Data;data infrastructure;Data Science;deep learning;Dependence;design;Disparity;economic disparity;Economics;Education;Elderly;Ensure;Environment;Environmental Exposure;environmental stressor;Equity;ethnic minority;Etiology;experience;Exposure to;extreme heat;Geography;Graph;graph neural network;Green space;Health;health disparity;health record;Heterogeneity;Hospitalization;Housing;Income;Individual;innovation;Instruction;Interdisciplinary Study;Intervention;Investigation;Joints;Justice;Label;Lead;Learning;learning network;lens;Link;Low income;low socioeconomic status;Machine Learning;machine learning method;marginalized population;Medical History;Medicare;Methodology;Methods;Mission;Modeling;multimodal learning;multimodality;National Institute of Environmental Health Sciences;Nature;Neighborhoods;neural network;Neural Network Simulation;novel;Outcome;Persons;Policies;Poverty;Predisposition;Process;Psychosocial Factor;Public Health;racial health disparity;racial minority;Recurrence;Reduce health disparities;Research;Research Support;Resolution;Risk;self supervised learning;signal processing;social determinants;social health determinants;spatiotemporal;statistical and machine learning;statistical learning;statistics;Strategic Planning;structural health determinants;Structure;Temperature;Time;tool;Training;Translational Research;United States;Violence;Vulnerable Populations;Weather;Work

PROJECT_TITLE: SCH: Synergizing Topological Deep Learning and Spatio-Temporal Causal Inference to Unpack Health

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IVBH-N (50)]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Cystic Fibrosis;Dental, Oral, and Craniofacial Disease;Infectious Diseases;Lung;Microbiome;Pediatric;Prevention;Rare Diseases

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: Project Narrative Individuals with cystic fibrosis (CF) have chronic respiratory infections. Oral diseases like tooth decay and gingivitis are potential sources of pathogenic bacteria that could spread from the mouth to the lungs, further compromising respiratory health. The proposed study will identify risk factors for oral diseases in adolescents and young adults with CF, evaluate associations between oral diseases and measures of respiratory health, and explore microbiologic links between oral and respiratory health using cutting-edge microbiome methods.

PI_NAMEs: CHI, DONALD LESLIE (contact);ROSENFELD, MARGARET

PROGRAM_OFFICER_NAME: BACCAGLINI, LORENA

PROJECT_TERMS: Address;Adolescence;Adolescent and Young Adult;Age;age group;aspirate;Attention;autosome;Bacteria;Behavior;Behavior Therapy;Behavioral;Biological;Biological Factors;Carbohydrates;care providers;Caring;Cariogenic Diet;Caucasians;Cessation of life;children with cystic fibrosis;Chronic;Clinical;cohort;Communication;Conflict (Psychology);Cystic Fibrosis;cystic fibrosis patients;Data;Dental;Dental caries;Dental Hygiene;Dental Plaque;Dentistry;Dentists;Diagnostic;Disease;disorder prevention;dysbiosis;early adolescence;Eating;Enrollment;Ensure;Environment;Epidemiology;Evidence based intervention;Food;Fruit;functional decline;Future;General Population;Gingivitis;Goals;Health;Health behavior;health data;Healthcare;high risk;Impairment;improved;Incidence;Individual;Inflammatory;insight;Intake;Intervention;Interview;Juice;Life;Life Expectancy;Link;loss of function;Lung;Lung Diseases;lung health;lung injury;lung microbiome;Measures;Mechanical ventilation;Medical;medical specialties;member;Methods;microbiome;Modeling;Modernization;Mouth Diseases;Mucociliary Clearance;Nurses;Obstructive Lung Diseases;Oral;oral bacteria;Oral cavity;Oral health;oral microbiome;Outcome;Parents;Participant;pathogenic bacteria;Pathogenicity;Pathway interactions;Patients;Pediatric Hospitals;peer;physical therapist;Pneumonia;Population;premature;Prevalence;Prevention;Preventive;Preventive dental care;preventive intervention;prospective;Provider;provider communication;Pulmonary Cystic Fibrosis;pulmonary function;pulmonary function decline;Pulmonary Function Test/Forced Expiratory Volume 1;Quality of life;Reflux;respiratory;respiratory health;Respiratory Tract Infections;response;Risk;Risk Factors;Saliva;Site;Social Workers;Source;Stomach;Streptococcus mutans;Surveys;Time;treatment planning;Weight;Weight Gain

PROJECT_TITLE: Understanding Oral Diseases in Cystic Fibrosis to Develop Tailored Preventive Dental Interventions


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: BIRMINGHAM

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Project Narrative In this training and transition proposal, I will focus efforts on the exploration of novel disease mechanisms that might underlie devastating diseases like Alzheimer’s disease, in the hopes of finding new mechanistically rationale therapeutic strategies that might slow or halt disease progression.

PI_NAMEs: LIU, ZHIYONG  (contact)

PROGRAM_OFFICER_NAME: BARRETT, PAUL JOHN

PROJECT_TERMS: 3' Untranslated Regions;Academia;Acceleration;Acute;Advisory Committees;Alleles;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease patient;Animal Model;apolipoprotein E-4;Atrophic;Attenuated;Automobile Driving;Biochemistry;Biology;Biophysics;Brain;candidate validation;career;Cells;Cellular biology;comparison control;Coupled;cytokine;Data;Disease;disease model;disease phenotype;Disease Progression;Disease susceptibility;experience;experimental study;Flow Cytometry;Foundations;Functional disorder;Future;Genetic;Genetic Variation;Goals;Grant;GTP Binding;GTPase-Activating Proteins;Guanine Nucleotide Exchange Factors;Guanosine Triphosphate;Guanosine Triphosphate Phosphohydrolases;Immune response;Immunologics;In Vitro;in vivo;Inflammasome;Inflammation;Inflammatory;Inflammatory Response;innate immune function;interest;Investigation;knock-down;Label;Laboratory Research;Link;Liquid substance;Mass Spectrum Analysis;Mediating;Membrane;Mentors;Mentorship;Messenger RNA;Microglia;Molecular;mouse model;Mus;Nerve Degeneration;Neurodegenerative Disorders;neuroinflammation;neuron loss;neuropathology;novel;Odds Ratio;Oligonucleotides;Pathology;Pathway interactions;Phagocytes;Phase;Phenotype;Postdoctoral Fellow;Predisposition;Process;protein aggregation;Publishing;rab GTP-Binding Proteins;recruit;Research;resilience;response;Role;Scanning;Series;Single Nucleotide Polymorphism;skills;tau aggregation;tau Proteins;Techniques;Testing;Therapeutic;trafficking;Training;transcriptomics;Universities;uptake;Work;Writing

PROJECT_TITLE: Role of Rab10 in Alzheimer's disease

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Adolescent Sexual Activity;Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Mental Health;Pediatric;Physical Injury - Accidents and Adverse Effects;Prevention;Social Determinants of Health;Substance Misuse;Substance Misuse Prevention;Underage Drinking;Violence Against Women;Violence Research;Women's Health Research;Youth Violence;Youth Violence Prevention

ORG_CITY: PITTSBURGH

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: In response to the call for research on bioethical issues to guide health-related, behavioral science research (NOT-OD-24-031), this proposed administrative supplement will focus on the processes necessary to co- create multi-level interventions for students with disabilities (SWD) to address the nexus of sexual violence (SV) exposure and heavy drinking. Particularly challenging for research and intervention development is the continued ‘invisibility’ of disabilities, the stigma associated with disabilities, intersections with other forms of marginalization such as racism, homophobia, and transphobia, and limited patient and community engagement in alcohol research. Thus, the bioethical issues to be addressed in this proposal are: 1) development of a shared framework for conducting research with college SWD designed with SWD and other constituents, and 2) identifying accessible human-centered design strategies to ensure full inclusion of SWD in co-creating prevention interventions that increase protective factors and reduce exposure to violence and alcohol misuse.

PI_NAMEs: MILLER, ELIZABETH  (contact)

PROGRAM_OFFICER_NAME: FREEMAN, ROBERT

PROJECT_TERMS: Address;Administrative Supplement;Administrator;Alcohol consumption;alcohol misuse;alcohol misuse prevention;alcohol research;alcohol risk;Alcohols;American;behavioral health;Behavioral Sciences;binge drinking;Bioethical Issues;care seeking;Caring;Climate;Clinical Trials;Collaborations;college;community engagement;Community of Practice;community partners;Competence;Counseling;design;Development;disability;Disability research;Disabled Persons;disabled students;diversity and inclusion;effective intervention;Ensure;Ethical Review;Ethics;experience;Goals;Harm Reduction;healing;Health;health inequalities;Heavy Drinking;high risk;Homophobia;human centered design;Human Resources;improved;Individual;Infrastructure;Intervention;intimate partner violence;Invisible disability;Justice;Learning;Learning Disorders;Life;Lived experience;marginalization;Mental disorders;Methodology;Mission;National Institute on Alcohol Abuse and Alcoholism;outreach;parenting intervention;Parents;patient engagement;Pharmaceutical Preparations;physical impairment;Population;Positioning Attribute;Prevention;prevention practice;Prevention program;preventive intervention;Procedures;Process;protective factors;Provider;Race;racism;Randomized, Controlled Trials;Recommendation;recruit;Reporting;reproductive;Research;research and development;response;Risk Reduction;Safety;Sensory impairment;Services;sexual assault;sexual violence;Sexual violence prevention;social stigma;Student Health Services;Students;Techniques;therapy development;transphobia;Trauma;university student;violence exposure;violence victimization;Work

PROJECT_TITLE: Alcohol use and sexual violence among college students with disability – co-creating inclusive research and prevention (Administrative Supplement NOT-OD-24-031 to R01 AA023260)

STUDY_SECTION: CLHP

STUDY_SECTION_NAME: Community-Level Health Promotion Study Section[CLHP]


ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: Project Narrative The objective of this application is to dissect immune mechanisms of biological sex differences in response to immunotherapy and the tumor microenvironment (TME).

PI_NAMEs: BROWN, BRIAN D (contact);SAMSTEIN, ROBERT M

PROGRAM_OFFICER_NAME: ZENKLUSEN, JEAN C

PROJECT_TERMS: biological sex;cofactor;Female;Genes;genetic analysis;Genetic Determinism;Immune;Immune response;Immunotherapy;male;neoplasm immunotherapy;parent grant;response;Sex Differences;tumor;Tumor Immunity;tumor microenvironment;tumor-immune system interactions

PROJECT_TITLE: Examining the effect of biological sex on the tumor microenvironment and immunotherapy response


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Brain Disorders;Drug Abuse (NIDA only);Genetics;HIV/AIDS;Infectious Diseases;Neurodegenerative;Neurosciences;Opioid Misuse and Addiction;Opioids;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Substance Misuse

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: PROJECT NARRATIVE Continued opioid abuse and HIV infection contribute to exacerbated neuroinflammation and neurocognitive impairments. The proposed project aims to define molecular mechanisms of opiate and HIV-induced NLRP1 inflammasome activation in iPSC-derived primary human microglia. These in vitro model systems will be leveraged to identify host pathways to prevent microgliosis and the resulting neuroinflammation, which are critical to preventing the neuropathogenesis of in HIV+ OUD+ patients.

PI_NAMEs: GUMMULURU, SURYARAM  (contact);HENDERSON, ANDREW J

PROGRAM_OFFICER_NAME: BORGMANN, KATHLEEN RUTH

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;antiretroviral therapy;Binding;Biological Models;C-terminal;CASP1 gene;Cell model;Cells;Chronic;chronic inflammatory disease;comorbidity;CRISPR/Cas technology;Cytoplasm;Development;Dissociation;Double-Stranded RNA;emerging pathogen;endoplasmic reticulum stress;epigenetic regulation;experience;experimental study;Exposure to;Functional disorder;Future;Genetic Transcription;Gliosis;HIV;HIV Infections;HIV-1;HIV-associated neurocognitive disorder;Homeostasis;Human;human induced pluripotent stem cells;Immune;immune activation;Immune System Diseases;in vitro Model;in vivo;Incidence;Individual;induced pluripotent stem cell;Infection;Inflammasome;Inflammation;Inflammatory;injection drug use;insight;Interleukin-1 beta;Interruption;Introns;Ligands;Link;Macrophage;Mediating;Microglia;Molecular;Morphine;mRNA Expression;Myeloid Cells;N-terminal;Neurocognitive;Neurocognitive Deficit;Neurodegenerative Disorders;neuroinflammation;Neurons;Neuropathogenesis;novel;novel therapeutic intervention;Nuclear Export;Nuclear RNA;Opioid;opioid abuse;opioid exposure;Opioid Receptor;opioid use;opioid use disorder;overdose death;pathogen;Pathogenesis;Pathway interactions;Patients;Peptide Hydrolases;Persons;Pharmaceutical Preparations;Play;polypeptide;Population;Predisposition;prevent;promoter;Proteins;proteotoxicity;Receptor Signaling;Regulation;response;restraint;RNA;RNA Binding;Rodent Model;Role;Signal Transduction;socioeconomics;Stress;Study models;Substance abuse problem;substance use;Testing;therapeutic development;Tissue Model;trafficking;Transcriptional Regulation;Transgenic Organisms;ubiquitin-protein ligase;Viral;Viral reservoir;Viremia

PROJECT_TITLE: Mechanisms of Persistent Inflammasome Activation in Myeloid Cells

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 SXC-N (O1)]


ED_INST_TYPE: GRADUATE SCHOOLS

ORG_NAME: COLUMBIA UNIV NEW YORK MORNINGSIDE

PHR: Project Narrative Comparative genomics and genetic engineering in model organisms are powerful tools that can be used to understand the biology underlying human traits, diversity and disease. We will study how essential proteins can evolve given the constraints imposed by the often multifaceted functions they perform, including for example, the important drug-target Na+,K+-ATPase, which has repeatedly evolved insensitivity to steroid inhibitors across diverse animals. Our work will yield insights into how new proteins associated with neurological and physiological disorders in humans, like Na+,K+-ATPase, can evolve new functions.

PI_NAMEs: ANDOLFATTO, PETER  (contact)

PROGRAM_OFFICER_NAME: ADKINS, RONALD

PROJECT_TERMS: Address;Amino Acid Substitution;Amino Acids;Animals;ATP phosphohydrolase;Behavior;Biology;Cardiac Glycosides;Chromosome Mapping;comparative genomics;Cre lox recombination system;CRISPR/Cas technology;Data;Dependence;Development;Disease;Drosophila genus;Drosophila melanogaster Proteins;Drug Targeting;Eating;Engineering;Evolution;Exhibits;experience;Fertility;fitness;Gene Expression Profiling;Genes;Genetic;genetic analysis;genetic architecture;Genetic Determinism;Genetic Drift;Genetic Engineering;Genetic Epistasis;Genetic Variation;Genome;genome editing;Genome engineering;genome wide association study;Genomics;Glycosides;Homeostasis;Human;Human Biology;human disease;In Vitro;in vivo;Individual;inhibitor;innovation;Insecta;insight;K ATPase;Learning;Link;Maps;model organism;Modeling;Molecular;Molecular Genetics;Mutation;Natural Selections;Nature;Neurologic;novel;Organism;Outcome;pathogenic bacteria;pathogenic virus;permissiveness;Phenotype;Physiological;Plants;Population;Population Genetics;Process;Property;protein function;Proteins;Quantitative Trait Loci;Recurrence;Resistance;Role;Shapes;Site;Steroids;System;Technology;Time;tool;Toxic effect;Toxin;trait;Variant;Vertebrates;whole genome;Work

PROJECT_TITLE: Effects of genetic background on adaptive evolution

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-GGG-B(02)M]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Gene Therapy;Genetics;Kidney Disease;Nanotechnology;Organ Transplantation;Regenerative Medicine;Transplantation

ORG_CITY: VILLANOVA

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: VILLANOVA UNIVERSITY

PHR: Project Narrative This project aims to develop a multi-faceted therapeutic strategy to reduce ischemia reperfusion injury related damage to the endothelium of transplanted kidneys. We propose that polymeric vehicles specifically tailored for endothelial cells will be able to efficiently deliver and sustain the release of siRNA to prevent these injury outcomes by temporarily silencing the key molecules in each case that propagate inflammation outside of the cell. This modular approach will allow us to address the two key sources of injury to endothelium and substantially reduce the impact of IRI for kidney transplant.

PI_NAMEs: BRACAGLIA, LAURA  (contact)

PROGRAM_OFFICER_NAME: POIZAT, CORALIE ISABELLE

PROJECT_TERMS: Address;Amines;Area;Arteries;Award;Biology;Biomedical Engineering;bioscaffold;Blood capillaries;Blood Vessels;Cell Adhesion Molecules;Cell Communication;cell injury;Cells;Characteristics;Charge;Chemicals;clinical translation;Coupling;delivery vehicle;density;design;Development;Doctor of Philosophy;Drug Delivery Systems;Endothelial Cells;Endothelium;Environment;Extracellular Matrix;Family;Fellowship;Fibrosis;Formulation;Goals;graft failure;Health;Human;human model;human tissue;Hydrogels;Hypoxia;Immune;Immunology;Immunosuppressive Agents;improved;In Vitro;in vivo;in vivo Model;Infiltration;Inflammation;Inflammatory;Inflammatory Response;inhibitor;Injections;injured;Injury;Injury to Kidney;insight;Intercellular adhesion molecule 1;Investigation;Kidney;kidney cortex;Kidney Transplantation;Kinetics;knock-down;Knowledge;Leukocytes;Long-Term Effects;Measures;Mediating;Methods;Molecular;nanoparticle;nanoparticle delivery;nanopolymer;Natural regeneration;Neutrophil Infiltration;novel;nucleic acid delivery;Nucleic Acids;Organ;Organ Model;Organ Transplantation;Outcome;Pathology;Penetration;Perfusion;Phase;Placenta;Polymers;Postdoctoral Fellow;prevent;Production;professor;Profibrotic signal;rational design;regeneration potential;renal damage;Reperfusion Injury;Research Personnel;resilience;response;response to injury;Risk;Role;Route;Science;siRNA delivery;Site;Small Interfering RNA;small molecule;Source;Structure;System;targeted treatment;Therapeutic;therapeutic nanoparticles;therapeutic siRNA;therapy duration;three-dimensional modeling;Tissue Model;Tissues;tool;Training;Transfection;Translating;translation to humans;Transplantation;Tubular formation;Universities;uptake;Vascular Cell Adhesion Molecule-1;vascular inflammation;Work

PROJECT_TITLE: Tailored siRNA delivery to human endothelium to inhibit and reverse inflammatory damage following ischemia reperfusion injury in the kidney


ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: MADISON

ORG_NAME: WISCONSIN DEPT/AGRI/TRADE/CONSUM/ PROT

ORG_STATE: WI

PHR: Project Narrative Several recent high-profile multi-state foodborne illness outbreaks highlighted the need for federal, state, and local food safety agencies to work together to prevent and respond to threats to the nation’s food supply. The Rapid Response Team program is a critical tool for promoting interoperability, consistency, and cooperation between federal and state agencies responsible for protecting the nation’s food supply and public health. The outcome of awarding this cooperative agreement to Wisconsin will advance efforts for a nationally integrated food safety system in Wisconsin.

PI_NAMEs: SPRECKER, TROY S (contact)

PROGRAM_OFFICER_NAME: ANDREWS, THANH

PROJECT_TITLE: Maintenance of Human and Animal Food Rapid Response Team - Wisconsin

STUDY_SECTION_NAME: Special Emphasis Panel[ZFD1 ORA-T (02)]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Kidney Disease;Nutrition;Obesity;Organ Transplantation;Prevention;Social Determinants of Health;Transplantation

ORG_CITY: HOUSTON

ORG_NAME: METHODIST HOSPITAL RESEARCH INSTITUTE

ORG_STATE: TX

PHR: PROJECT NARRATIVE Living kidney donation, where someone donates one kidney while alive to someone whose own kidneys don’t function, provides the best outcomes for kidney patients needing renal replacement therapy. The growing prevalence of obesity in society reduces the numbers of potential living donors, since motivated individuals who have a high body mass index (BMI) are eliminated from being medically screened as donors and are not offered any support to help them lose weight. There is an urgent need to address issues of fairness in screening, comprehension of risks and benefits for both potential donors and recipients if a potential donor lost weight, and, if indicated, access to weight loss education and support programs. By interviewing excluded obese potential living donors about their views, experiences, and education and weight loss needs, this project will produce empirically informed recommendations and draft tools that support ethical and equitable decisions about living donation in situations when potential donors are obese.

PI_NAMEs: WATERMAN, AMY DOGGETTE (contact)

PROGRAM_OFFICER_NAME: SERRANO, KATRINA JANE

PROJECT_TERMS: access disparities;Acute;Address;Affect;Altruism;Area;Benefits and Risks;Bioethics;Body mass index;Body Weight decreased;Characteristics;Clinical;clinical care;Clinical Research;Communication;Comprehension;Computerized Medical Record;Country;Data;Decision Aid;Decision Making;diverse data;Donor Exclusions;Donor Selection;Education;Effectiveness;Eligibility Determination;Emotional;End stage renal failure;Equity;Ethical Analysis;Ethics;ethnic minority;Evaluation;Exclusion;experience;Health;health assessment;health equity;high body mass index;Hypertension;improved;Individual;Inequity;information gathering;interest;Interview;Justice;Kidney;Kidney Transplantation;Knowledge;Living Donors;living kidney donor;Measures;Medical;Methods;Motivation;obese person;Obesity;obesity risk;Organ;Outcome;Patients;Population;pressure;Prevalence;Process;programs;Proxy;Questionnaires;racial minority;Recommendation;Renal Replacement Therapy;Resources;Risk;Scholarship;screening;Societies;sociodemographics;Structure;success;support tools;Surveys;Techniques;Testing;transplant centers;Transplantation;Waiting Lists;Weight;weight loss intervention;Work

PROJECT_TITLE: Improving transplantation access, equity and outcomes through responsive risk communication and support for living donor candidates with obesity.


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Infectious Diseases;Sexually Transmitted Infections

ORG_CITY: TUCSON

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: The proposed work will provide insights into the interplay between prevalent cancer-causing human papillomaviruses (HPVs) and the host cell. From this work Amy Banka will analyze existing RNA Seq data of HPV(+) and HPV(-) human tumors to understand how HPV regulates establishment of infection and long-term persistence, the risk factor for HPV-associated cancers.

PI_NAMEs: VAN DOORSLAER, KOENRAAD  (contact)

PROGRAM_OFFICER_NAME: ALARCON, RODOLFO M

PROJECT_TERMS: acute infection;Alternative Splicing;Anogenital cancer;Biology;biomarker identification;Cells;Cervical;chronic infection;clinical practice;Data;Deposition;Development;Event;Genes;Genome;Genomic approach;genomic data;Head and Neck Cancer;Human;human data;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;Incidence;Infection;insight;Life Cycle Stages;Malignant Neoplasms;Messenger RNA;Network-based;new therapeutic target;Phase;Protein-Arginine N-Methyltransferase;Publishing;Risk Factors;Sexually Transmitted Diseases;single cell genomics;transcriptome;transcriptome sequencing;transcriptomics;tumor;tumor progression;Viral;Virus;Virus Diseases;Work

PROJECT_TITLE: Identifying HPV-host interactions using network-based analysis of preexisting transcriptomic data


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

ORG_CITY: Princeton

ORG_DEPT: CHEMISTRY

ORG_NAME: PRINCETON UNIVERSITY

ORG_STATE: NJ

PHR: Project Narrative This MIRA project will use theoretical methods, closely coupled with experimental data, to elucidate the basic factors that control the movement of electrons and protons in biological systems, providing fundamental insights into a wide range of biochemical processes essential to living systems. In particular, this project will enhance understanding of the radical translocation mechanism of ribonucleotide reductase, which plays a critical role in DNA synthesis, replication, and repair. The general insights about controlling electrons and protons provided by this work may also have broader implications for protein engineering, drug design, and optogenetics.

PI_NAMEs: HAMMES-SCHIFFER, SHARON  (contact)

PROGRAM_OFFICER_NAME: GERSHENSON, ANNE

PROJECT_TERMS: alpha helix;Biochemical;Biochemical Process;Biological;Biological Models;Biological Process;biological systems;Biomimetics;Cell Respiration;Complex;Coupled;Cryoelectron Microscopy;Data;DNA biosynthesis;Drug Design;Electron Transport;Electronics;Electrons;Electrostatics;Environment;Enzymes;Equilibrium;Goals;Hydrogen;Individual;insight;kinetic model;Kinetics;Length;Measurement;Methods;Molecular Conformation;molecular dynamics;Motion;Movement;multi-scale modeling;Nuclear;Nucleotides;optogenetics;Organism;Pathway interactions;Play;Process;protein complex;Protein Conformation;Protein Engineering;Proteins;Protons;prototype;quantum;quantum chemistry;Reaction;repaired;Ribonucleotide Reductase;Role;Series;Solvents;Structure;Theoretical Studies;theories;Thermodynamics;Time;Tryptophan;Tyrosine;Work

PROJECT_TITLE: Coupled Protons and Electrons in Biological Systems

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-Q(55)R]


NIH_SPENDING_CATS: HIV/AIDS

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PI_NAMEs: SMITH, DAVID MITCHELL (contact)

PROGRAM_OFFICER_NAME: NOVAK, LEIA KAYE


ED_INST_TYPE: OVERALL MEDICAL

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;HPV and/or Cervical Cancer Vaccines;Immunization;Infectious Diseases;Pediatric;Prevention;Sexually Transmitted Infections;Social Determinants of Health;Vaccine Related

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: PROJECT NARRATIVE HPV incidence rates are high among traditional college-aged adults (i.e., young adults aged 18-26 years) – a population that continues to display alarmingly low rates of HPV vaccination (i.e., <60% of all U.S. college students have received the first dose of the vaccine). We expect this diversity supplement project will: (1) identify factors associated with interpersonal barriers to HPV vaccination, specifically perceived HPV vaccine disapproval from friends and family; (2) provide important insights into how perceived HPV vaccine disapproval from important others impacts the HPV vaccine decision-making process; and (3) highlight the ability of the parent grant’s multilevel narrative-based intervention to decrease perceived HPV vaccine disapproval from important others and, consequently, increase HPV vaccine uptake among college students. It is expected that this diversity supplement project will have a significant impact on future intervention implementation approaches that address the most influential interpersonal relationships (e.g., parents and friends) to increase HPV vaccination uptake among young adults, specifically college students.

PI_NAMEs: LU, QIAN  (contact)

PROGRAM_OFFICER_NAME: KOBRIN, SARAH

PROJECT_TERMS: Address;Adolescent and Young Adult;Adult;Affect;Age;Age Years;aged;Area;Attitude;Behavior;Behavior Therapy;Behavioral;cancer invasiveness;Centers for Disease Control and Prevention (U.S.);Childhood;college;Communities;Control Groups;Data;Data Analyses;Decision Making;design;Disease;Dose;effective intervention;Ethnic Origin;evidence base;experience;Family;Financial Hardship;follow-up;Friends;Future;Gardasil;Goals;health care availability;health care delivery;high risk;HPV vaccine acceptance;Human papilloma virus infection;Human Papilloma Virus Vaccination;Human Papilloma Virus Vaccine;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;implementation intervention;improved;Incidence;Individual;Individual Differences;infection rate;Influentials;innovation;insight;Intention;Interpersonal Relations;Intervention;Knowledge;Linear Regressions;Literature;Logistic Regressions;Malignant Neoplasms;Mediating;Mediation;Medical Records;men;Methods;metropolitan;Modeling;Online Systems;parent grant;Parents;Patient Self-Report;peer;Persons;Persuasive Communication;Pilot Projects;Population;Positioning Attribute;prevent;primary outcome;Process;programs;psychosocial;Public Health;Randomized;Recommendation;Research Project Grants;Schools;Science;secondary outcome;Self Efficacy;skills;social;social norm;social stigma;sociodemographics;stakeholder perspectives;System;Testing;Texas;Theoretical model;therapy design;Treatment Efficacy;United States;university student;unvaccinated;Vaccinated;Vaccination;vaccination outcome;vaccine access;vaccine hesitancy;Vaccines;Woman;Work;young adult

PROJECT_TITLE: Promoting HPV Vaccination among Young Adults in Texas


ADMINISTERING_IC: NR

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Depression;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Mental Illness;Neurosciences;Pain Research;Primary Health Care;Racial and Ethnic Minority Health Research

ORG_CITY: INDIANAPOLIS

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Project Narrative Barriers to using evidence-based nonpharmacologic pain treatments are especially prevalent for Black patients—who are offered fewer pain treatment options than White patients—and for patients with depression, since depressive symptoms can interfere with pain management. EQUIPD (Equity Using Interventions for Pain and Depression) is a novel intervention using a decision aid focused on nonpharmacologic treatments, combined with tailored individual coaching, to help Black patients with depression increase their use of these treatments to improve pain outcomes. Project results have important implications for improving equity in pain care for Black patients with depression by increasing use of safe, effective pain treatments.

PI_NAMEs: MATTHIAS, MARIANNE S (contact)

PROGRAM_OFFICER_NAME: KEHL, KAREN

PROJECT_TERMS: Address;Adherence;Administrator;Anxiety;Appointment;arm;black patient;Caring;chronic depression;chronic pain;chronic pain patient;Clinic;Clinic Visits;Clinical Trials;comorbid depression;comorbidity;comparison intervention;Consultations;Control Groups;Data;Data Collection;Decision Aid;depressive symptoms;Development;Disparity;Effectiveness;effectiveness testing;effectiveness/implementation study;empowerment;Equity;evidence base;experience;follow-up;Fostering;future implementation;Goals;Health;Health system;Healthcare;Healthcare Systems;heuristics;implementation barriers;implementation facilitation;improved;Individual;individual patient;Intervention;intervention delivery;Intervention Trial;Interview;Knowledge;Learning;Life Style;Lived experience;Manuals;Mental Depression;minority patient;multilevel analysis;multimodality;Nonpharmacologic Therapy;novel;novel strategies;Outcome;Pain;pain catastrophizing;Pain interference;Pain management;pain outcome;patient engagement;patient-clinician communication;patient-level barriers;Patients;Pharmaceutical Preparations;Phase;pilot test;preference;primary care clinic;primary care provider;primary outcome;Procedures;Protocols documentation;Provider;racial disparity;Racial injustice;Randomized;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;recruit;Research;Resources;safety net;Sampling;secondary outcome;socioeconomic disadvantage;Structure;System;Testing;Time;treatment adherence;treatment comparison;treatment guidelines;Waiting Lists;Work

PROJECT_TITLE: Equity Using Interventions for Pain and Depression (EQUIPD)


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Pediatric;Prevention;Serious Mental Illness

PHR: PROJECT NARRATIVE Borderline personality disorder (BPD) is a serious mental illness associated with comorbidity across internalizing and externalizing pathology as well as high personal and societal cost. This study will use a high-risk design to assess problematic interpersonal behavior exhibited by children with their friends to determine whether it reflects a precursor to BPD or other internalizing and externalizing problems. Results will provide critical information about hypothesized disease trajectory for BPD, which will inform targets for prevention and early intervention.

PI_NAMEs: VANWOERDEN, SALOME  (contact)

PROGRAM_OFFICER_NAME: BECHTHOLT, ANITA JEAN

PROJECT_TERMS: Administrative Supplement;Behavior;Borderline Personality Disorder;career;career development;caregiving;Child;comorbidity;Data;Data Collection;design;Disease;Early Intervention;Event;Exhibits;First Births;Friends;Funding;high risk;Life;Mentored Research Scientist Development Award;Mentors;Methods;middle childhood;Mothers;Paper;parent project;Parents;Participant;Pathology;Personality;Persons;preventive intervention;Process;Productivity;recruit;Research;Research Design;Sampling;Schedule;severe mental illness;societal costs;Specialist;Time;timeline;Training;Work;Writing

PROJECT_TITLE: Dysfunctional behavior with friends during middle childhood as a precursor to borderline personality pathology - Supplement

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


ORG_CITY: DENVER

ORG_NAME: NATIONAL ENVIRONMENTAL HEALTH ASSOCIATION

ORG_STATE: CO

PHR: PROJECT NARRATIVE The National Environmental Health Association (NEHA) project entitled Using Technology, Data, and Collaboration to Expand SLTT Conformance with the Voluntary National Retail Food Regulatory Program Standards is intended to:   Work with FDA and project partners to develop, refine, and improve the grant  management system we developed to administer financial assistance to SLTT retail  regulatory food programs based on FDA's Retail Flexible Funding Model (RFFM) vision;   Maintain the Self-Assessment and Verification Audit Online Course we developed in  partnership with FDA and expand its use and value to SLTT jurisdictions;   Establish the NEHA-NACCHO Mentor Academy to recruit and train a new generation of  mentors, expanding our capacity to meet the increasing demand for expertise in the  Retail Program Standards; and   Work with CFP and FDA to host a biennial Retail Program Standards Symposium and  an annual Virtual RFFM Grant Year Kickoff Meeting, to engage current and attract new  enrollees in the Retail Program Standards. These four objectives will advance the Integrated Food Safety System (IFSS) requirements found in the Food Safety Modernization Act (FSMA) and support the goal of building New Business Models and Retail Standardization in the New Era of Smarter Food Safety.

PI_NAMEs: DYJACK, DAVID T (contact)

PROGRAM_OFFICER_NAME: NIESEN, MARIBETH

PROJECT_TITLE: Using Technology, Data, and Collaboration to Expand SLTT Conformance With the Voluntary National Retail Food Regulatory Program Standards

STUDY_SECTION_NAME: Special Emphasis Panel[ZFD1 ORA-T (03)]


NIH_SPENDING_CATS: Aging;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Estrogen;Genetics;Nanotechnology;Precision Medicine;Urologic Diseases

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

ORG_STATE: MA

PHR: PROJECT NARRATIVE SRD5A2 is a critical enzyme for prostatic development and growth, and the SRD5A2 inhibitor, finasteride, is used to treat benign prostatic hyperplasia (BPH). SRD5A2 is absent in 30% of normal adult men, which explains the resistance of a subset of patients to this commonly prescribed drug. This project proposes new combination therapies (5-ARI+raloxifene) and evaluates novel non-invasive biomarkers, based on alternative pathways that lead to prostatic enlargement.

PI_NAMEs: OLUMI, ARIA F (contact)

PROGRAM_OFFICER_NAME: KIRKALI, ZIYA

PROJECT_TERMS: 5 Alpha-Reductase Inhibitor;Accounting;Adrenergic alpha-Antagonists;Adult;Age;androgenic;Androgens;Animal Model;bench to bedside;Benign Prostatic Hypertrophy;Binding;Biological Markers;Bladder;Clinical;Clinical Trials;clinically significant;cohort;Combined Modality Therapy;cost;DNA;DNA Binding;Drug Prescriptions;Drug usage;Effectiveness;Enzymes;epigenetic marker;Epigenetic Process;epigenetic silencing;estrogenic;Estrogens;ferumoxytol;Finasteride;follow-up;genetic signature;Growth;Growth and Development function;Healthcare Systems;Human;Hypermethylation;improved;indexing;Inflammation;Inflammation Mediators;Inflammatory;inflammatory marker;information gathering;inhibitor;inhibitor therapy;Interleukin-6;International;Investigation;Laboratory Finding;Leukocytes;lower urinary tract symptoms;Magnetic Resonance Imaging;male;Measures;Medical;men;Methylation;Modification;nanoparticle;new combination therapies;Newly Diagnosed;NF-kappa B;novel;novel marker;novel therapeutic intervention;Obesity;Obstruction;Operative Surgical Procedures;Oxidoreductase;Pathway interactions;patient subsets;Patients;peripheral blood;predicting response;Prediction of Response to Therapy;predictive signature;promoter;Promoter Regions;prospective;Prostate;Prostatic;protein expression;Proteins;Quality of life;Radiology Specialty;Raloxifene;Randomized;Resistance;resistance mechanism;response;Role;Secondary to;Selective Estrogen Receptor Modulators;Signal Transduction;SRD5A2 gene;Steroids;Symptoms;Techniques;Tissues;TNF gene;Transferase;Translating;treatment arm;treatment response;treatment strategy;Work;years of life lost

PROJECT_TITLE: New Treatment Strategies and Epigenetic Biomarker for Management of BPH

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 KUDS-W (05)]


NIH_SPENDING_CATS: Aging;Cancer;Childhood Leukemia;Hematology;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: RICE UNIVERSITY

PHR: NARRATIVE Acute myeloid leukemia (AML), a hematological malignancy, remains stubbornly difficult to treat in both children and adults, with fewer than 30% of patients surviving five years after diagnosis. This project tests a novel treatment target (mitochondrial recycling—aka mitophagy) and novel small molecules identified using cheminformatics, in AML cell lines and primary cells. This project will facilitate the identification and characterization of promising leads for the development of future therapies.

PI_NAMEs: KIRIENKO, NATASHA  (contact)

PROGRAM_OFFICER_NAME: COVELL, DAVID G

PROJECT_TERMS: Acute leukemia;Acute Myelocytic Leukemia;acute myeloid leukemia cell;Adult;Affect;Aftercare;Age Years;Agonist;analog;Antineoplastic Agents;Apoptosis;Apoptotic;Automobile Driving;Bioinformatics;Biological;Biological Assay;Blast Cell;Blood Cells;Bone Marrow;Bone Marrow Cells;cancer cell;Cell Death;Cell Death Inhibition;Cell Differentiation process;Cell division;Cell Line;Cell Proliferation;Cell Survival;Cells;Cessation of life;Chemical Structure;Chemicals;cheminformatics;Child;Coupling;cytotoxic;cytotoxicity;Data;Defect;Development;Diagnosis;Disease remission;Doxorubicin;effective therapy;Engraftment;exhaustion;experimental study;Family;Family member;Foundations;Future;Genetic;genetic approach;Glutathione;Glutathione Reductase;Health;Hematologic Neoplasms;high throughput screening;Homeostasis;Human;human old age (65+);Immune;improved;in silico;innovation;Lead;leukemia;leukemia treatment;Leukemic Cell;leukemic stem cell;life span;Malignant - descriptor;Mammalian Cell;Measures;Mediating;member;Metabolic;Metabolism;metabolomics;Mitochondria;Molecular Target;mortality;mouse model;Mus;Names;Newly Diagnosed;novel;older patient;Oxidation-Reduction;Oxygen Consumption;Parkin;Pathway interactions;patient derived xenograft model;Patients;Peripheral Blood Mononuclear Cell;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;Phenotype;Phosphotransferases;PINK1 gene;preclinical study;Probability;Production;Prognosis;Publishing;Recycling;Relapse;Research;screening;side effect;small molecule;Solubility;stem cells;Structure;Structure-Activity Relationship;synergism;System;Testing;Therapeutic;Toxic effect;Toxin;transcriptomics;Treatment Efficacy;Tumor Burden;TXN gene;Validation;Work

PROJECT_TITLE: Diversity Supplement: Cheminformatics-based identification of leukemia-targeting molecules


NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Neurosciences;Post-Traumatic Stress Disorder (PTSD)

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative Low frustration tolerance and uncontrolled aggression are common and impairing symptoms in psychiatric disorders as varied as PTSD, bipolar disorder, and autism. Little is known, however, about the neural basis of these behaviors. This proposal uses cutting-edge technologies to reveal the neural circuits underlying frustration and aggression, with the ultimate goal of developing more effective therapies for patients across multiple disorders.

PI_NAMEs: ESHEL, NEIR  (contact)

PROGRAM_OFFICER_NAME: VAN'T VEER, ASHLEE VICTORIA

PROJECT_TERMS: Advisory Committees;Aggressive behavior;Anger;Animals;autism spectrum disorder;Behavior;Biological Assay;Bipolar Disorder;Calcium;career;career development;conditioning;Disease;Disparate;Dopamine;dopaminergic neuron;effective therapy;Electrophysiology (science);Environment;Event;experimental study;Fellowship;Fiber;Frustration;Goals;Growth;Head;Human;Image;Impairment;Mental disorders;Mentors;motivated behavior;mouse model;Mus;neural;neural circuit;Neurobiology;Neuromodulator;Neurons;news;Nucleus Accumbens;optogenetics;Outcome;Patients;Photometry;Positioning Attribute;Post-Traumatic Stress Disorders;Process;Psychiatry;Research Personnel;response;Rewards;Rodent;Role;Serotonin;Social Behavior;Symptoms;Technology;Testing;Training;translational research program;Violence;Work

PROJECT_TITLE: Neural circuits of frustration

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Neurosciences

ORG_CITY: Chicago

ORG_NAME: NORTHWESTERN UNIVERSITY

ORG_STATE: IL

PHR: PROJECT NARRATIVE Correlations in neural dynamics across the brains of interacting individuals are an emergent and highly conserved property of social interactions, but the functional relevance of these correlations remains enigmatic. In this proposal we will use a comparative multi-species approach, combining state-of-the-art wireless technological advances and cellular/subcellular resolution imaging with pioneering molecular-genetic tools to decipher the biological mechanisms that enable neural synchrony and unequivocally define its function. By moving beyond a correlative understanding of this intriguing emergent neural property, we will determine its role in successful social interaction and attachment, a finding with transformative implications for the manipulation of these dynamics in a therapeutic context.

PI_NAMEs: DONALDSON, ZOE REBECCA;KOZOROVITSKIY, YEVGENIA  (contact);ROGERS, JOHN

PROGRAM_OFFICER_NAME: DAVID, KAREN KATE

PROJECT_TITLE: Dynamic entanglements: the functional role and mechanistic basis of inter-individual neural synchrony


ED_INST_TYPE: PRIMATE CENTERS

NIH_SPENDING_CATS: Clinical Research;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Methamphetamine;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: ATLANTA

ORG_DEPT: PATHOLOGY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE The goal of HIV cure research is to eliminate persistent virus (“the HIV reservoir”) to overcome the need for lifelong antiretroviral therapy (ART) and improve clinical outcomes in people with HIV (PWH), but a challenge in achieving worldwide HIV eradication is targeting specific vulnerable populations who are most likely to benefit from an HIV cure and possess poorer immune responses due to chronic inflammation and ongoing HIV reservoir activation. Our preliminary data suggests that PWH with methamphetamine (MA) dependence disorder, even with adequate ART suppression, have elevated inflammation and HIV reservoir transcription. The proposed work will now leverage a unique longitudinal cohort of PWH on ART with and without MA use to determine the underlying mechanisms by which MA may lead to immune dysfunction, focusing on the NOD-like receptor family pyrin domain containing 3 (NRLP3) inflammasome activation pathway.

PI_NAMEs: LEE, SULGGI ANGELA;PEREIRA RIBEIRO, SUSAN  (contact)

PROGRAM_OFFICER_NAME: POLLOCK, JONATHAN D

PROJECT_TERMS: Age;Antibodies;antibody-dependent cell cytotoxicity;antigen-specific T cells;antiretroviral therapy;ATAC-seq;Autoantibodies;B-Lymphocytes;Binding;Biological Assay;Blood;Blood specimen;Cell Therapy;Cells;Cerebrospinal Fluid;Chromatin;Chronic;Clinical;clinical remission;cohort;cytokine;Data;Dependence;Disease;Disease remission;Epigenetic Process;Exhibits;experience;experimental study;Family;Flow Cytometry;flu;Functional disorder;Future;Genetic Transcription;glycosylation;Goals;high dimensionality;high risk population;histone modification;HIV;HIV Seronegativity;human study;Immune;immune function;Immune response;Immune System Diseases;Immunity;Impairment;improved;In Vitro;in vivo;Individual;Inflammasome;Inflammation;Inflammatory Response;Institutional Review Boards;Interferons;Interruption;IRF4 gene;Literature;Longitudinal cohort;marenostrin;Mediating;Metabolic;Metabolism;metabolomics;Methamphetamine;Methamphetamine dependence;methamphetamine effect;methamphetamine exposure;methamphetamine use;Methods;Methylation;Modification;Morbidity - disease rate;mortality;neutralizing antibody;neutrophil;novel;Outcome;Oxidative Phosphorylation;Pathway interactions;Patients;Persons;Phagocytosis;Plasma;Post-Translational Protein Processing;Process;Production;programmed cell death protein 1;prospective;Reactive Oxygen Species;receptor;Regulatory T-Lymphocyte;Research;Residual state;response;RNA;Sampling;Secondary to;sialylation;Signal Transduction;single cell sequencing;systemic inflammatory response;T cell response;T-Lymphocyte;Testing;Therapeutic;therapeutic target;therapy adherence;Time;Transforming Growth Factor beta;Vaccination;Validation;Viral;Viral reservoir;viral RNA;Virus;Vulnerable Populations;Work

PROJECT_TITLE: Methamphetamine Activation of Inflammasome and Altered immunity in HIV (MAIA) Study


NIH_SPENDING_CATS: Genetics;Infectious Diseases

ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: PROJECT NARRATIVE While it is now accepted that cell-to-cell variability affects viral infection outcome, we currently lack mechanistic understanding as to the host factors and transcriptional programs that control it. To gain such mechanistic insights requires the development of new approaches that are able to connect the cell’s initial state with infection outcome. This project will develop and apply state-of-the-art single cell approaches to decipher the molecular mechanisms that control viral infection outcomes at the single cell level.

PI_NAMEs: DRAYMAN, NIR  (contact)

PROGRAM_OFFICER_NAME: DUPUY, LESLEY CONRAD

PROJECT_TERMS: Affect;Anti-viral Response;Anti-viral Therapy;Award;Biological Models;Biology;Cell Fraction;Cells;Cellular biology;cellular imaging;Collaborations;Custom;Data;design;Development;doctoral student;Gene Expression;Genetic Transcription;Germ Cells;Goals;Herpesvirus 1;high reward;high risk;improved;Infection;Infection Control;innovation;insight;Integration Host Factors;Investments;Life Cycle Stages;Literature;live cell imaging;Machine Learning;machine learning algorithm;Measurement;Methodology;Microfluidic Microchips;Microfluidics;Modality;Modeling;Molecular;Monitor;National Institute of Allergy and Infectious Disease;NF-kappa B;novel;novel strategies;Outcome;pathogen;pathogenic virus;Pathway interactions;Phenotype;Positioning Attribute;Probability;Process;Production;Productivity;programs;rational design;Research;Research Personnel;Resources;Science;secondary infection;Shapes;single-cell RNA sequencing;Supervision;System;Systems Biology;Technology;Testing;Therapeutic;Time;Titrations;TNF gene;tool;transcription factor;Validation;Viral;Viral Genes;virology;Virus;Virus Diseases;virus genetics;virus host interaction;Virus Replication;Work

PROJECT_TITLE: Harnessing cell-to-cell variability to understand viral infection outcomes


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: ITHACA

ORG_NAME: CORNELL UNIVERSITY

PHR: NARRATIVE Viruses that are able to establish persistent or chronic infections have developed strategies to suppress immune mechanisms that would normally eradicate the virus. Regulating inflammation in the face of persistent infection is also critical as many of the long-term problems of chronic infection are due to persistent inflammation, including increased risk of developing cancer. Our new data have uncovered an unexpected role for IL-17 in helping to limit T cell activation and inflammation as persistent infection becomes established, and here we propose to explore the sources and functions of IL-17 in immunoregulation of antiviral response.

PI_NAMEs: MCGEACHY, MANDY J (contact)

PROGRAM_OFFICER_NAME: JOFFE, AARON MICHAEL

PROJECT_TERMS: Adoptive Transfer;Anti-viral Response;Antibodies;antiviral immunity;Attention;Automobile Driving;Bacteria;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Count;Cell Physiology;Cell Proliferation;Cell Survival;Cells;cellular targeting;Chronic;chronic autoimmune disease;chronic infection;Chronic Phase;Clinical;Data;design;Development;Elements;exhaustion;extracellular;fungus;Future;Gene Expression Profiling;Genes;Genetic;Hepatitis B;HIV;IL17 gene;Immune;Immune response;Immunity;immunopathology;immunoregulation;Immunosuppression;improved;Infection;Inflammation;Inflammatory Response;Interferon Type II;Invaded;Kinetics;Lead;Lymphocytic choriomeningitis virus;Lymphoid;Lymphoid Tissue;Malignant Neoplasms;Mediating;Metabolic;Metabolic Pathway;microbiota;Modeling;Molecular Profiling;Morbidity - disease rate;Mus;novel;Outcome;pathogen;Pathology;Pathway interactions;Persons;Population;Production;Proliferating;Regulation;Regulatory T-Lymphocyte;response;Reticular Cell;Risk;Role;Signal Transduction;Source;Stromal Cells;Surface;T-Cell Activation;T-Lymphocyte;Testing;Therapeutic;Therapeutic Intervention;Time;tissue repair;Viral;Virus;Virus Diseases

PROJECT_TITLE: IL-17 regulation of type-1 immunity in chronic viral infection

STUDY_SECTION: IHD

STUDY_SECTION_NAME: Immunity and Host Defense Study Section[IHD]


ORG_CITY: BALTIMORE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PHR: PROJECT NARRATIVE Synthetic oligonucleotide therapeutics are a promising class of biopharmaceuticals to treat various diseases which to date have been undruggable by small molecules or protein therapeutics. This project will develop new and innovative methods to determine the extent, range, and biological activity of phosphorothioate diastereomers for synthetic oligonucleotides. The developed methods will greatly improve the efficiency of developing new synthetic oligonucleotide drugs and enable the development of safe, effective, and affordable generic products.

PI_NAMEs: FLETCHER, STEVEN ;JONES, JACE W (contact);WANG, HONGBING

PROGRAM_OFFICER_NAME: ZHANG, DEYI

PROJECT_TITLE: Comprehensive assessment of the diastereomer composition of LEQVIO (Inclisiran) to determine how chemical synthesis impacts biological activity

STUDY_SECTION_NAME: Special Emphasis Panel[ZFD1 CDER-T (08)]


ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Project Narrative Herein, we investigate how nanotube between prostate cancer cells and immune cells alter the effect of immunotherapeutic drugs. We utilize human and mice cell lines above human tissue to test the presence of nanotubes, while applying a novel class of inhibitors called endosidins to synergize with present immune check point inhibitors. The expected results of this study will avail a mechanism to explain poor immunogenicity in prostate cancers while availing new targets for therapy.

PI_NAMEs: SENGUPTA, SHILADITYA  (contact)

PROGRAM_OFFICER_NAME: SOMMERS, CONNIE L

PROJECT_TERMS: Actins;American;androgen deprivation therapy;androgen independent prostate cancer;Androgen Receptor;AR gene;Biological Assay;Bioluminescence;Biomedical Engineering;Breast;Breast Cancer Cell;cancer cell;cancer immunotherapy;CD8B1 gene;Cell Death;Cell Survival;Cells;Coculture Techniques;Complex;Confocal Microscopy;Cytotoxic T-Lymphocytes;design;Development;Early Diagnosis;Effector Cell;efficacy evaluation;Endothelium;Epigenetic Process;Evaluation Research;Functional disorder;Gene Expression Regulation;Genetic Transcription;Genus Hippocampus;Goals;Human;Human Cell Line;human tissue;Immune;Immune checkpoint inhibitor;immune resistance;Immune response;Immunocompromised Host;immunogenicity;immunoregulation;Immunotherapeutic agent;Immunotherapy;improved;inhibitor;Interferon Type II;Knowledge;Laboratory Research;Ligands;LNCaP;Malignant neoplasm of prostate;Malignant Neoplasms;Mediating;men;Mesenchymal Stem Cells;Metabolic;metabolic phenotype;Mitochondria;Modeling;Mouse Cell Line;Mus;Nanotubes;Neoplasm Metastasis;new therapeutic target;novel;novel therapeutics;Outcomes Research;patient derived xenograft model;PC3 cell line;Pharmaceutical Preparations;pharmacologic;Phenotype;Physiological;Prognosis;prostate cancer cell;prostate cancer cell line;prostate cancer progression;Receptor Activation;Research;Resistance development;response;Role;Scanning Electron Microscopy;stem;stemness;synergism;T-Lymphocyte;targeted cancer therapy;targeted treatment;Testing;Therapeutic;therapy resistant;Tissues;tool;tumor

PROJECT_TITLE: Tunneling Nanotube Inhibitors for Cancer Immunotherapy

STUDY_SECTION: INN

STUDY_SECTION_NAME: Innovations in Nanosystems and Nanotechnology Study Section [INN]


ORG_CITY: LEXINGTON

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: PROJECT NARRATIVE This project seeks to examine whether innovative local tobacco control policies restricting sales of flavored tobacco products can reduce tobacco use and disparities in tobacco and, ultimately cancer. The study will examine trajectories of flavored tobacco use in a large longitudinal national cohort of youth and young adults among those exposed and not exposed to policy. It will also examine youth and young adult non-tobacco user exposure to tobacco marketing and subsequent tobacco use outcomes in real-time in eight communities with different flavor policy variants and will have a particular focus on assessing differences in policy impact across vulnerable group status.

PI_NAMEs: ROSE, SHYANIKA W (contact)

PROGRAM_OFFICER_NAME: RODITIS, MARIA LEIA

PROJECT_TERMS: Acceleration;Affect;Age;Area;cancer health disparity;career;Cessation of life;Cigarette;cigarette smoking;cohort;Cohort Studies;Communities;Complement;Data;Data Collection;Data Set;Disparity;Disparity population;Ecological momentary assessment;Electronic cigarette;electronic cigarette use;emerging adult;Ensure;Equation;Equity;ethnic minority;Ethnic Origin;evidence base;Exposure to;follow-up;Goals;Health;health disparity;health equity promotion;High School Student;implementation framework;Individual;Inequity;innovation;insight;Longitudinal cohort;Longitudinal cohort study;Longitudinal trends;low socioeconomic status;Malignant neoplasm of lung;Malignant Neoplasms;marginalization;Marketing;Mediating;Mediation;Methods;Modeling;Morbidity - disease rate;mortality;Neighborhoods;Outcome;parent grant;Participant;people of color;Persons;Play;Policies;Population;Populations at Risk;Prevalence;Protocols documentation;public policy on tobacco;Race;racial difference;racial minority;reduce tobacco use;Research;Research Personnel;Role;Sales;Socioeconomic Status;Structure;Surveys;Testing;Time;Tobacco;tobacco advertising;tobacco exposure;tobacco flavor;Tobacco Industry;tobacco products;tobacco regulatory science;Tobacco use;Training;United States;uptake;Variant;Visit;vulnerable community;Vulnerable Populations;young adult;Youth

PROJECT_TITLE: Local Flavor Policies to Enhance Equity in Tobacco - A Diversity Supplement


NIH_SPENDING_CATS: Hematology;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: MILWAUKEE

ORG_NAME: VERSITI WISCONSIN, INC.

PHR: PROJECT NARRATIVE Signals communicating the need to maintain balanced blood production and aged blood cell removal must be correctly conveyed to the marrow's hematopoietic stem and progenitor cells and covey proper blood cell removal signals. These molecular mechanisms are intensely studied to provide new insight into the potential for novel therapeutic approaches in blood disorders, specifically affecting platelet and red blood cell counts. The proposed work will yield a transformative understanding of how liver-produced factors contribute to maintaining red blood cell production in the bone marrow at a steady state and provide new insight into novel therapeutic approaches for patients with blood disorders.

PI_NAMEs: HOFFMEISTER, KARIN MARIA (contact)

PROGRAM_OFFICER_NAME: WARREN, RONALD Q

PROJECT_TERMS: Affect;aged;Binding;Biochemical;Blood;Blood Cells;Blood Platelets;Bone Marrow;bone marrow mesenchymal stem cell;Calgranulin A;Calgranulin B;Carbohydrates;Cells;Communication;cytokine;Data;Defect;Development;Dysmyelopoietic Syndromes;Epidermal Growth Factor Receptor;ERBB2 gene;ERBB3 gene;ErbB4 gene;Erythrocytes;erythroid differentiation;Erythropoiesis;Excision;extracellular;Family;genetic approach;genome wide association study;Hematological Disease;Hematopoiesis;Hematopoietic stem cells;Hemoglobin concentration result;Hepatic;Hepatocyte;Human;inhibitor;insight;Investigation;Island;Leukocyte L1 Antigen Complex;Ligands;Liver;Maintenance;Marrow;Mediating;Megakaryocytes;member;Mesenchymal Stem Cells;Molecular;mouse model;Mus;Myelodysplastic/Myeloproliferative Disease;neuregulin-4;novel therapeutic intervention;Patients;Production;progenitor;programs;receptor;Receptor Protein-Tyrosine Kinases;Recombinants;Red Blood Cell Count;Role;S100 Calcium Binding Protein;S100 Proteins;Signal Transduction;stem cell function;stem cell homeostasis;therapeutic development;Thrombopoietin;transcriptomics;Variant;Work


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative The proposed supplement will provide insights into the development of patient centered, ethical standards for data-sharing through evaluation of data sharing preferences and governance for disseminating that data with external recipients. This program of bioethics research will also inform bioethics-related policy through providing an evidence base for future directions. The proposed research is relevant to the NINDS’s mission to investigate neuroethical questions to improve neurological health for all people, especially those experiencing health disparities and populations underrepresented in science.

PI_NAMEs: GAUDINO, MARIO FL;MASTERSON CREBER, RUTH MARIE (contact);SWARTZ, RICHARD

PROGRAM_OFFICER_NAME: YIN, XILING

PROJECT_TERMS: Address;Adult;Age;Area;Asian;Bioethics;Black race;Brain Embolism;Brain imaging;Brain Injuries;career;Characteristics;Clinical Research;Cognition;cohort;Communities;Coronary Artery Bypass;Data;data access;data sharing;data standards;Dementia;Development;Ensure;Ethics;ethnic minority;ethnic minority population;Evaluation;evidence base;experience;Female;Fostering;Future;Gender;Goals;Health;health disparity;Health Policy;Healthcare;Image;Impaired cognition;improved;Individual;Informed Consent;insight;Institutional Policy;Interview;member;Minor;minority communities;Mission;National Institute of Neurological Disorders and Stroke;Neurocognitive;Neurologic;Neurosciences Research;Nurses;parent grant;Parents;Participant;patient oriented;Patients;Pattern;Persons;Physicians;Policies;Population;preference;Productivity;programs;Public Participation;public trust;Publications;Race;racial minority;racial minority population;recruit;Reporting;Representational Oligonucleotide Microarray Analysis;Research;Research Personnel;research study;Respondent;Sampling;Science;Scientist;screening;Site;social stigma;sociodemographics;Stroke;Structure;Surveys;Training;Trust;Underrepresented Populations;United States;United States National Institutes of Health;virtual;willingness;Work

PROJECT_TITLE: Strengthening Healthcare and Research Engagement through Data Sharing: SHARE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]