ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

ORG_CITY: CAMBRIDGE

ORG_NAME: BROAD INSTITUTE, INC.

PHR: PROJECT NARRATIVE The focus of our project is to understand how the cells of the human brain vary from person to person, in the genes they use, and in how they are spatially organized within brain tissue. Through a detailed study of this variation, we seek to deepen our understanding of how the human brain works, and uncover the cellular and molecular basis for vulnerability to neurodevelopmental, neuropsychiatric, and neurological disorders.

PI_NAMEs: MACOSKO, EVAN Z;MCCARROLL, STEVEN ANDREW (contact)

PROGRAM_OFFICER_NAME: YAO, YONG

PROJECT_TERMS: Acute;Adult;Alleles;Area;ATAC-seq;Atlases;Biodiversity;Biological;Biological Process;Biology;Brain;brain cell;Brain Diseases;brain tissue;Cell Nucleus;cell type;Cells;Complex;Creativeness;Data;Data Analyses;data resource;Disease;Empathy;Equipment and supply inventories;Exhibits;experience;Gene Expression;Genes;Genetic;Genetic Predisposition to Disease;Genetic Risk;Genetic Variation;Genomic Segment;Genomics;Goals;Human;Human body;Human Genetics;Humanities;Individual;insight;inter-individual variation;Learning;Machine Learning;Measurement;Measures;Mental disorders;Molecular;molecular dynamics;molecular shape;Nervous System Disorder;Neuroanatomy;Neurodevelopmental Disorder;neuroimaging;neuropsychiatric disorder;new technology;Pattern;Persons;Phenotype;Physiology;postnatal development;postnatal human;Problem Solving;Process;programs;Regulon;Resolution;Sampling;scaffold;Shapes;single nucleus RNA-sequencing;Slice;Slide;Spatial Distribution;Specimen;Structure;Tissues;transcription factor;transcriptomics;translational neuroscience;Unmarried person;Variant;Vulnerable Populations;Work

PROJECT_TITLE: An Atlas of Human Brain Cell Variation


ADMINISTERING_IC: HL

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Biotechnology;Hematology;Infectious Diseases;Lung;Machine Learning and Artificial Intelligence;Rare Diseases;Regenerative Medicine;Sepsis;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: MAYWOOD

ORG_COUNTRY: UNITED STATES

ORG_DEPT: SURGERY

ORG_FIPS: US

ORG_NAME: LOYOLA UNIVERSITY CHICAGO

ORG_STATE: IL

PHR: Narrative: We have found new molecules in the extracellular cargos of BALF from ARDS patients. These proteins are related to stem cell-mediated repair of injured lungs. Drugs that target these signals may benefit patients' recovery.

PI_NAMEs: JI, HONG-LONG  (contact)

PROGRAM_OFFICER_NAME: ZHOU, GUOFEI

PROJECT_TERMS: 3-Dimensional;Acute Respiratory Distress Syndrome;Alveolar;alveolar epithelium;autocrine;Bacterial Infections;Bass;Bioinformatics;Biological Markers;Biological Specimen Banks;biomarker identification;Biomedical Engineering;Biometry;Bronchoalveolar Lavage;Bronchoalveolar Lavage Fluid;candidate marker;Catalysis;Cell Lineage;Cells;Classification;Clinical;Clinical Data;Clinical Research;Clinical Trials;cohort;Data;data repository;design;differential expression;Disease;Double-Blind Method;Drug Targeting;druggable target;Early Diagnosis;Enzymes;Epithelial Cells;epithelial injury;epithelial stem cell;Epithelium;epithelium regeneration;Etiology;exosome;extracellular;extracellular vesicles;Gastrointestinal tract structure;Goals;Hospital Mortality;Human;Impairment;In Vitro;in vivo;in vivo Model;Infection;Influenza;injury and repair;Kidney;Lavage;Liver;Lung;lung injury;lung regeneration;lung repair;machine learning algorithm;Mediating;Mediator;Methodology;Modeling;mortality;Multiple Organ Failure;Mus;National Heart, Lung, and Blood Institute;Natural regeneration;novel;novel marker;Organ;organ injury;Organoids;Outcome;Oxygen;paracrine;Paracrine Communication;Pathogenesis;Pathologic Processes;Pathway interactions;Patients;Pharmacologic Substance;Pharmacy (field);Pneumonia;preclinical study;Process;Prognosis;protein biomarkers;Proteins;Proteomics;Randomized Controlled Clinical Trials;re-epithelialization;Recovery;regenerative;Regulation;repaired;Role;Sampling;Sepsis;sepsis induced ARDS;septic;Septic Shock;Severities;Signal Pathway;Signal Transduction;Signaling Molecule;stem cell fate;stem cell therapy;stem cells;Stratification;success;supervised learning;Testing;Tissues;United States National Institutes of Health;urogenital tract;Validation;Virus Diseases

PROJECT_TITLE: Novel exosomal niches for alveolar stem cell-bassed repair of ARDS

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Genetics;Human Genome;Mental Health;Neurosciences

ORG_CITY: SEATTLE

ORG_NAME: ALLEN INSTITUTE

ORG_STATE: WA

PHR: NARRATIVE A major obstacle in basic and clinical neuroscience is a fundamental lack of knowledge of the cellular components of the human brain, the genes that contribute to their properties, how they form the functional circuitry of the brain, how they are differentially vulnerable in disease, and how similar they are in organisms used in biomedical research as experimentally tractable models of human disease. The goal of the proposed research is to create a comprehensive cell atlas of the human and closely related non-human primate brain, using high-throughput single cell molecular, spatial and cell phenotyping assays to map the structural and functional organization of the primate brain. The result will be a transformative catalytic resource for the basic science and biomedical community linking brain structure, function, cellular makeup and genomic characteristics that provide a powerful new foundation to accelerate understanding of human brain function and disease.

PI_NAMEs: LEIN, ED  (contact);ZENG, HONGKUI

PROJECT_TERMS: Acceleration;Acute;Adult;Anatomy;Architecture;ATAC-seq;Atlases;Automobile Driving;Basic Science;Behavior;Behavioral;Biological Assay;Biomedical Research;Brain;brain cell;brain circuitry;Brain Diseases;Brain Mapping;Brain region;brain tissue;Callithrix;Cell Physiology;cell type;Cells;Characteristics;Classification;Clinical;cohort;Communities;comparative;Complex;computerized data processing;Consensus;Consent;Coupled;Data;data integration;data management;data mining;data resource;data standards;data visualization;Development;Didelphidae;Disease;electrical property;end of life;Enhancers;Ensure;epigenomics;Foundations;Freezing;Frustration;Functional Imaging;Functional Magnetic Resonance Imaging;Genes;Genetic;Genomics;Goals;Hippocampus;Histologic;Human;human disease;human model;human subject;human tissue;Image;in vivo;in vivo imaging;Individual;inter-individual variation;Knowledge;Label;Link;Macaca;Magnetic Resonance Imaging;Mammals;Maps;Measures;member;Methods;model organism;Modeling;Molecular;Molecular Analysis;Molecular Profiling;Monkeys;Moods;Morphology;multimodality;Mus;Nerve Tissue;Nervous System Disorder;neuroethics;neuroimaging;Neurons;Neurosciences;neurosurgery;nonhuman primate;Ontology;Organism;Outcome;Pan Genus;patch sequencing;Pattern;Perception;Phenotype;Population;Primates;Property;Reference Standards;Research;Resected;Resources;Rodent;Sampling;sex;single cell genomics;single cell technology;single nucleus RNA-sequencing;Slice;Specimen;structural imaging;Structure;study population;Subcellular Anatomy;Taxonomy;Techniques;Technology;tissue culture;Tissues;tool;transcriptome;transcriptomics;Variant;Visualization software;Work

PROJECT_TITLE: Functionally guided adult whole brain cell atlas in human and NHP


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: STANFORD

ORG_DEPT: PATHOLOGY

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: NARRATIVE The highly aggressive brain cancer glioblastoma (GBM), is a major unmet medical need and the existing pharmacopeia is thin and ineffective. New and better treatments are needed for this devastating cancer. By combining powerful new chemical proteomic technologies with genetically-defined, translationally relevant GBM models, this proposal aims to discover and characterize druggable proteins for the inhibition of growth of EGFR-ampified GBMs, enriching our understanding of the biochemical dependencies displayed by this currently untreatable cancer type and providing compelling new molecular targets for transforming the care of GBM patients.

PI_NAMEs: CRAVATT, BENJAMIN F;MISCHEL, PAUL S (contact)

PROGRAM_OFFICER_NAME: FORRY, SUZANNE L

PROJECT_TERMS: Acceleration;activity-based protein profiling;Address;Adult Glioblastoma;American Association of Cancer Research;Astrocytes;Automobile Driving;Award;Biochemical;Biology;Brain;cancer type;Caring;Cell membrane;Cells;Chemicals;Chemistry;chemoproteomics;Clinical;clinical risk;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;Data;Dependence;Development;drug candidate;drug development;effective therapy;Epidermal Growth Factor;Evolution;experimental study;extrachromosomal DNA;Failure;Frequencies;Genes;Genetic Heterogeneity;Genomics;Glioblastoma;Growth;Growth Factor;Growth Factor Oncogenes;Heterogeneity;high risk;Human;human induced pluripotent stem cells;In Vitro;in vivo;inhibitor;Libraries;Ligands;Lipid Synthesis Pathway;Malignant neoplasm of brain;Malignant Neoplasms;Medical;member;Membrane Lipids;Metabolic;Methods;Modeling;Molecular;Molecular Biology;Molecular Target;National Cancer Institute;neuro-oncology;novel;novel therapeutics;overexpression;particle;Patients;Pharmaceutical Chemistry;pharmacologic;Pharmacopoeias;Phenotype;Plasma;Play;Positioning Attribute;Program Development;Proteins;Proteomics;Resistance;Role;Route;screening;Signal Transduction;small molecule libraries;Stereotyping;Structure;Technology;therapeutic target;Thinness;tumor;tumor growth;Validation;Work;Writing

PROJECT_TITLE: Integrated ligand and target discovery by chemical proteomics for glioblastoma treatment.

STUDY_SECTION: DMP

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology Study Section[DMP]


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Cancer;Clinical Research;Health Services;Lung;Lung Cancer;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Social Determinants of Health

ORG_CITY: DAVIS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: NARRATIVE Cancer continues to rank as the second leading cause of death in the US. We propose to study how teamwork, specifically communication and information sharing among large numbers of healthcare professionals, impact their patients’ outcome.

PI_NAMEs: MA, KWAN-LIU ;SEWELL, DANIEL ;TU, SHIN-PING  (contact);ZHU, XI

PROGRAM_OFFICER_NAME: BRICK, RACHELLE SOPHIA

PROJECT_TERMS: Academy;Accident and Emergency department;Address;Affect;Aftercare;aging population;Algorithms;analytical tool;beneficiary;Breast;cancer care;cancer diagnosis;Cancer Patient;cancer therapy;care systems;Caregivers;Cause of Death;Cessation of life;Clinical;Cognition;Colorectal;Combined Modality Therapy;Communication;Communication difficulty;comorbidity;cost;Data;Decision Making;design;digital;Dimensions;Discipline;effectiveness evaluation;Electronic Health Record;Emergency department visit;Fast Healthcare Interoperability Resources;Focus Groups;Future;Goals;graph neural network;health care delivery;Health Professional;Healthcare;Hospitalization;improved;Information Management;information processing;innovation;interest;Intervention;Intervention Studies;Interview;Knowledge;Machine Learning;Malignant Neoplasms;Measures;Mediating;Medical;Medicare;Medicine;Methods;Modeling;mortality;National Cancer Institute;National Research Council;Non-Small-Cell Lung Carcinoma;novel;Outcome;Pathway Analysis;Patient Care;Patient-Centered Care;Patient-Focused Outcomes;Patients;Performance;Policies;Population;Positioning Attribute;prototype;Quality of Care;Recommendation;Reporting;Research;Risk Reduction;Role;Site;social health determinants;Social Network;Structure;System;Systems Theory;Technology;theories;time use;tool;Treatment Protocols;United States;Visual;Visualization;Work

PROJECT_TITLE: SMART Cancer Care Teams: Enhancing EHR Communication to Improve Interprofessional Teamwork

STUDY_SECTION: CDMA

STUDY_SECTION_NAME: Clinical Data Management and Analysis Study Section[CDMA]


ADMINISTERING_IC: NS

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Chronic Pain;Clinical Research;Estrogen;Genetics;Headaches;Migraine;Neurosciences;Pain Research;Women's Health Research

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: Project Narrative: Migraine is a disorder of recurrent incapacitating headache that disproportionately affects women as compared to men. The global burden of this economically and socially costly disorder highlights the need to understand sex differences in migraine. This study will examine mechanisms involved in sex differences in migraine by exploring the role of sex steroid hormones and the hypothalamus in an animal model of migraine with aura.

PI_NAMEs: HARRIOTT, ANDREA M (contact)

PROGRAM_OFFICER_NAME: SYPEK, ELIZABETH IRENE

PROJECT_TERMS: Abate;Acceleration;Acute;Address;allodynia;Animal Model;Aptitude;Behavior;Behavioral;behavioral study;Brain region;career;career development;cell type;Cells;Classic Migraine;clinical candidate;Common Migraine;cost;Craniotomy;cutaneous allodynia;differential expression;disability;Disabling;Disease;Disproportionately impacts women;Doctor of Philosophy;Economic Burden;epidemiology study;Estradiol;Estrogens;Estrus;experience;experimental study;Female;Foundations;Funding;Future;Gene Cluster;Gene Expression;General Hospitals;Genetic;Genetic Transcription;Goals;Gonadal Hormones;Gonadal Steroid Hormones;Headache;Headache Disorders;Hormonal;Hormones;hypocretin;Hypothalamic Hormones;Hypothalamic structure;Image;In Situ;in vivo;instructor;Intervention;Knowledge;Lateral;Light;Machine Learning;male;Massachusetts;Measures;mechanical allodynia;medical schools;men;Menarche;Meningeal;Menstruation;Mentors;Mentorship;Methods;Migraine;minimally invasive;Modeling;Motor;Mus;Neurology;Neurons;Neuropeptides;Nociception;Nociceptors;novel;optogenetics;Orchiectomy;Outcome Study;Pain;pain behavior;painful neuropathy;Patients;Pharmaceutical Preparations;Phenotype;Physicians;Population;Postmenopause;pre-clinical;Pre-Clinical Model;preclinical study;Progesterone;Recurrence;Research;Research Personnel;response;Rodent;Role;Sensory;Severities;sex;Sex Differences;sex disparity;sexual dimorphism;single-cell RNA sequencing;skills;social;Speech;Spreading Cortical Depression;spreading depression;Stress;Sumatriptan;targeted treatment;Testing;Testosterone;Therapeutic Intervention;Training;Training Programs;transcriptomics;Trigeminal Nuclei;Trigeminal Pain;Trigeminal System;Visual;Woman

PROJECT_TITLE: Sex Differences in the Role of Gonadal Hormones and the Hypothalamus in Migraine with Aura.

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-1 Study Section[NST-1]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Genetics;Mental Health;Neurodegenerative;Neurosciences

ORG_CITY: La Jolla

ORG_NAME: SALK INSTITUTE FOR BIOLOGICAL STUDIES

PHR: Project Narrative To navigate daily life, novel experiences must constantly be compared to prior experiences to determine whether prior information is still accurate or if conditions have changed. This project will link novel-experience- induced changes in individual neurons of the dentate gyrus, which is critical for distinguishing between similar experiences, to physiological states in which memory function is enhanced or impaired. Understanding the link between gene expression in individual cells and memory function will reveal novel targets for maintaining healthy memory and restoring function in aging and disease.

PI_NAMEs: GAGE, FRED H (contact)

PROGRAM_OFFICER_NAME: LEINWAND, SARAH GOLDBERG

PROJECT_TERMS: addiction;Adult;adult neurogenesis;Aging;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;APP-PS1;Area;Attention;behavioral response;Biological Process;Brain region;Candidate Disease Gene;cell type;Cells;Cognitive;cognitive enhancement;cognitive function;combat;Data;dentate gyrus;Discrimination;Disease;Effectiveness;Enkephalins;Environment;Event;experience;experimental study;FOS Protein;Functional disorder;functional restoration;Gene Expression;Gene Expression Profile;Gene Proteins;Genes;Genetic;Genetic Transcription;granule cell;Health;healthy aging;Hippocampus;Immediate-Early Genes;Impaired cognition;Impairment;improved;Individual;individual response;knock-down;Knowledge;Learning;Life;Link;Memory;memory encoding;Memory Loss;memory process;Methods;Molecular;Molecular Profiling;Morphology;mouse model;Mus;Neurodegenerative Disorders;neurogenesis;Neurons;novel;novel therapeutics;overexpression;Pathologic;Pathway interactions;Pattern;Physiological;Population;Process;proenkephalin;Pyramidal Cells;response;Rewards;Role;Running;segregation;Series;single nucleus RNA-sequencing;Techniques;Testing;theories;Tissue Preservation;transcriptomics;Wild Type Mouse;Work

PROJECT_TITLE: Dynamics of activity-induced transcription in single dentate granule cells

STUDY_SECTION: NCF

STUDY_SECTION_NAME: Neurogenesis and Cell Fate Study Section[NCF]


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Climate-Related Exposures and Conditions;Mental Health;Mental Illness;Neurosciences;Pediatric;Schizophrenia;Serious Mental Illness;Social Determinants of Health

ORG_CITY: ROCHESTER

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF ROCHESTER

ORG_STATE: NY

PHR: Project Narrative Air pollution exposures are linked to male-biased neurodevelopmental disorders such as schizophrenia, autism spectrum disorder and attention deficit hyperactivity disorder. These studies examine whether developmental air pollution exposures produce classic schizophrenia features, as well as the role of copper contamination of air pollution and activated microglial cells in initiating this neurotoxicity.

PI_NAMEs: CORY-SLECHTA, DEBORAH A (contact)

PROGRAM_OFFICER_NAME: HOLLANDER, JONATHAN

PROJECT_TERMS: Adolescence;Adolescent;Adverse effects;air contaminant;Air Pollution;Animal Model;Animals;Attention deficit hyperactivity disorder;Attenuated;autism spectrum disorder;Behavior;Behavioral;Biochemical;Biological;Brain;Brain region;Characteristics;Cognitive;Cognitive deficits;Copper;Corpus Callosum;cytokine;density;Dependence;design;Development;Disease;Dopamine;emerging adult;Environmental Risk Factor;Epidemiology;epidemiology study;Etiology;Exhibits;Exposure to;Female;glial activation;Glutamates;gray matter;Health protection;high risk;Human;human model;Impairment;Impulsivity;Inflammation;Inflammatory;Inhalation;Inhalation Exposure;inhibitor;Interneurons;Intervention;lateral ventricle;Link;Literature;male;Mediating;Mental disorders;Metals;Microglia;Minocycline;Motor;Mus;Mutation;myelination;nanoparticle;Neurodevelopmental Disorder;Neurons;neuropathology;neuropsychiatric disorder;neurotoxic;neurotoxicity;Oxidation-Reduction;Oxides;particle exposure;Parvalbumins;Pattern;Phenotype;postnatal;prepulse inhibition;Property;Public Health;Regulation;Reporting;response;Risk;Risk Factors;risk minimization;risk mitigation;Role;Schizophrenia;schizophrenia risk;Sensory;Serum;sex;Sex Differences;social;Stimulus;Symptoms;Synapses;synaptic pruning;Testing;ultrafine particle;white matter

PROJECT_TITLE: Air Pollution and Male-Biased Psychiatric Disorders

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Colorectal Cancer;Digestive Diseases;Genetics;Precision Medicine;Radiation Oncology

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE Colorectal cancer is the third leading cause of cancer-related death, despite significant advances in treatment options. This study utilizes cell-level optical metabolic imaging of patient-derived organoid cultures to predict sensitivity of a patient’s cancer to different modalities prior to treatment. This will guide the personalization of treatment options for individual patients such that the maximum benefit can be achieved with the least amount of toxicities necessary.

PI_NAMEs: DEMING, DUSTIN A (contact)

PROGRAM_OFFICER_NAME: SORG, BRIAN S

PROJECT_TERMS: 3-Dimensional;Aftercare;Age;anti-cancer treatment;Applications Grants;Architecture;Biopsy;Cancer Biology;cancer cell;Cancer Etiology;Cancer Model;Cancer Patient;Cell Communication;Cells;Cessation of life;chemotherapy;Chemotherapy and/or radiation;Clinical;clinical imaging;clinical predictors;Clinical Treatment;Clinical Trials;Clonal Evolution;Coenzymes;cohort;colon cancer patients;Colorectal Cancer;Complex;Correlation Studies;Data;Development;Diameter;Disease;Disease Resistance;Dose;driver mutation;effective therapy;Enrollment;Ethnic Origin;Exposure to;Fluorescence;Fluorouracil;Future;Gender;Generations;Genes;Genetic;Genetic Heterogeneity;Genotype;Goals;Heterogeneity;Human;Image;Imaging technology;improved;in vivo;Individual;individual patient;individualized medicine;interest;Investigational Therapies;Lymphocyte Count;Magnetic Resonance Imaging;Malignant Neoplasms;Measures;Metabolic;metabolic imaging;Metabolism;metastatic colorectal;Methods;Modality;Modeling;Molecular;Molecular Evolution;Molecular Profiling;mortality;Multivariate Analysis;Mus;Mutation;NADH;Neoadjuvant Therapy;novel;Oncology;Operative Surgical Procedures;optical imaging;Optics;Organoids;parent grant;Pathologic;Patient imaging;patient response;Patient-Focused Outcomes;Patients;personalized medicine;Pharmaceutical Preparations;Pilot Projects;Population Density;predict clinical outcome;predicting response;Prediction of Response to Therapy;Primary Neoplasm;Prior Therapy;prospective;Protocols documentation;Race;Radiation;Radiation therapy;Rectal Cancer;Regimen;Registries;Research Technics;response;Sampling;screening;Secondary to;side effect;single cell analysis;spheroids;Staging;standard care;standard of care;Stromal Neoplasm;System;Techniques;Technology;Testing;Therapeutic;Time;tool;Toxic effect;Toxicity due to chemotherapy;Transgenic Organisms;treatment response;tumor;Tumor-Infiltrating Lymphocytes;Xenograft procedure

PROJECT_TITLE: Optical imaging to predict cell-level genetic heterogeneity and treatment sensitivity in colorectal cancer


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Contraception/Reproduction;Disability Research;Health Services;Prevention

ORG_CITY: MINNEAPOLIS

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE Tanzania has among the most significant adverse reproductive health statistics of any country and high rates of persons with disabilities who are invisible in reproductive healthcare, yet health professionals receive no training in how to address reproductive health concerns in persons with disabilities. To address multiple, intersecting, sex-related epidemics, and to train the professionals who do everything from staffing clinics to writing national policies, we need effective, evidence-based, culturally tailored, reproductive health curriculum. This study will conduct the formative research needed to develop the strongest reproductive health curriculum for healthcare providers treating Tanzanian people with disabilities, revise and pilot test it, and conduct a randomized controlled trial of the intervention against a waitlist control, on health worker ability to effectively address reproductive health concerns for people with disabilities.

PI_NAMEs: MARK, KRISTEN PATRICIA (contact);MKOKA, DICKSON ALLY

PROGRAM_OFFICER_NAME: POPKIN, RONNA

PROJECT_TERMS: acceptability and feasibility;Address;Adopted;Africa;Africa South of the Sahara;African;Age;Ally;arm;Attitude;Blinded;Caregivers;Caring;Christianity;Clinic;Communities;Community Health;comparison control;Consult;Counseling;Country;design;Development;disability leave;Disability outcome;Disabled Persons;Discipline;Discipline of Nursing;Discrimination;Education;Educational Curriculum;effectiveness evaluation;efficacy testing;Ensure;Environment;Epidemic;Evaluation;evidence base;Exclusion;experience;Face;Faculty;Focus Groups;follow-up;Funding;Future;Government;Health;health care delivery;health communication;Health education;health knowledge;Health Personnel;Health Professional;Health Services;health training;Healthcare;high risk;HIV;improved;Indigenous;Individual;informant;intervention effect;Intervention Trial;Interview;Knowledge;Language;Learning;Lived experience;low income country;Medical Students;Medicine;Midwifery;Modeling;Morbidity - disease rate;mortality;Muslim religion;Needs Assessment;neglect;Nursing Students;Outcome;Pan American Health Organization;Participant;patient population;Patients;Persons;pilot test;Policies;Population;Pregnancy in Adolescence;Professional Education;professional students;provider behavior;Randomized;Randomized, Controlled Trials;Recording of previous events;Religion;Reproductive Health;Research;Research Personnel;routine care;Science;secondary analysis;sex;sexual and reproductive health;Sexual Health;sexual violence;Sexually Transmitted Diseases;single-blind trial;skill acquisition;skills;social;social stigma;statistics;Structure;Students;Taboo;Tanzania;Testing;Trainers Training;Training;Training Programs;treatment arm;Tribes;unintended pregnancy;United States National Institutes of Health;Universities;Waiting Lists;Writing

PROJECT_TITLE: Training Healthcare Professionals to Address Reproductive Health for Persons with Disabilities in Tanzania


NIH_SPENDING_CATS: Cancer;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunotherapy;Precision Medicine;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: The overarching goal of the proposed Paul Calabresi Award in Clinical Oncology (PCACO) K12 is to nurture and inspire the clinical and translational patient oriented research career development of future clinically impactful transdisciplinary investigators pursuing therapeutic and biomarker innovation. Ultimately, the intent of the PCACO K12 is to launch and advance the careers of the next generation of independently funded clinical and translational researchers, armed with the methodological skills, analytical acumen, & scientific knowledge required to successfully address meaningful unmet needs in the treatment and/or prevention of cancer, which in turn will significantly impact the health and well-being of the community which we serve and society at large.

PI_NAMEs: BHARDWAJ, NINA  (contact);FERRARA, JAMES L. M.

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: Address;anti-cancer research;anti-racism;Basic Science;cancer immunotherapeutics;Cancer Intervention;cancer therapy;career;career development;Career Mobility;Clinical;Clinical Investigator;Clinical Oncology;Clinical Research;Clinical Sciences;Clinical Trials;Communities;Data Science;Development;Doctor of Philosophy;drug discovery;drug repurposing;Education;education research;Entrepreneurship;Environment;equity, diversity, and inclusion;Evaluation;Faculty;Funding;Future;Goals;graduate school;Immunotherapeutic agent;improved;Individual;innovation;Institution;Interdisciplinary Communication;Intervention Trial;Justice;K-Series Research Career Programs;Knowledge;Leadership;Learning;Malignant Neoplasms;Master of Science;medical specialties;Medicine;Mentored Clinical Scientist Development Program;Mentors;Methodology;multidisciplinary;multiple omics;next generation;novel;Oncologist;Oncology;Outcome;patient oriented;patient oriented research;pedagogy;Population;precision medicine;Professional Competence;Program Development;programs;recruit;Research;Research Activity;Research Personnel;Research Training;resilience;response;Science;Social Responsibility;Structure;success;Talents;Therapeutic;tool;Training;Translational Research;United States National Institutes of Health

PROJECT_TITLE: The Tisch Cancer Institute (TCI) Paul Calabresi K12 Career Development Award for Clinical Oncology

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Eating Disorders;Mental Health;Nutrition;Obesity;Physical Activity;Prevention;Telehealth

ORG_CITY: PROVIDENCE

ORG_NAME: MIRIAM HOSPITAL

ORG_STATE: RI

PHR: PROJECT NARRATIVE In the field of behavioral obesity treatment, there is an increased emphasis on developing remote-based interventions to reach more individuals, while also shifting the focus of these programs to successful long-term weight loss. The current study addresses both research priorities and seeks to fill critical gaps in the yoga and weight control fields. Findings from this trial have the potential to improve obesity treatment, through consideration of yoga as a viable intervention component, and aid in a greater understanding of the mechanisms through which yoga impacts weight within the context of a weight management program.

PI_NAMEs: UNICK, JESSICA L (contact)

PROGRAM_OFFICER_NAME: MUDD, LANAY MARIE

PROJECT_TERMS: Address;Adherence;Adult;Affect;Behavior;Behavioral;Binge Eating;Body mass index;Body Weight Changes;Body Weight decreased;Calories;Cellular Phone;Characteristics;Child Care;Cognitive;cognitive reappraisal;cohort;Control Groups;cost;COVID-19;craving;dietary;Dimensions;Discipline;distress tolerance;Eating;Ecological momentary assessment;effective intervention;emotion regulation;Emotional;emotional eating;Emotions;ethnic diversity;Ethnic Origin;Exhibits;Expenditure;experience;follow-up;Future;Gender;Geography;Goals;Health;Hyperphagia;improved;India;Individual;Informal Social Control;internet delivery;Intervention;Length;Life;Literature;loss of control over eating;Mediator;men;Mental Depression;mindfulness;mode of exercise;novel strategies;Obesity;Obesity Epidemic;obesity management;obesity treatment;online care;online delivery;Outcome;Overweight;Pain;Participant;Pathway interactions;Persons;Pilot Projects;primary outcome;Process;programs;psychologic;Questionnaires;Race;Randomized;randomized trial;Reporting;Research;Research Priority;response;Risk;Risk Factors;Sample Size;Sampling;satisfaction;secondary outcome;Self Efficacy;self-compassion;skills;smoking cessation;Stress;stressor;Surveys;Syndrome;systematic review;Testing;Thinking;Travel;treatment effect;videoconference;Videoconferencing;Weight;weight loss intervention;weight loss program;Weight maintenance regimen;Weights and Measures;Wellness Program;Work;Yoga

PROJECT_TITLE: A remote-based yoga intervention for improving long-term weight loss


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human

ORG_DEPT: ANATOMY/CELL BIOLOGY

PHR: Project Narrative Understanding the molecular controls of hair follicle stem cells and progenitors is essential for developing future hair regenerative therapies. We will explore the signaling mechanisms by which the dermal sheath regulates progenitor cell death during the regression phase of the hair cycle. This work will provide insights into stem cell and progenitor regulation by dermal sheath cells.

PI_NAMEs: RENDL, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: BELKIN, ALEXEY

PROJECT_TERMS: Ablation;Apoptosis;base;Biological Assay;Cell Communication;Cell Death;Cells;Cessation of life;Chromatin;chromatin immunoprecipitation;Color;combinatorial;Complex;Contracts;Data;Dedications;Dermal;epithelial stem cell;Future;Gene Expression;Genetic;Genetic Transcription;Germ;Goals;Growth;Hair;Hair follicle structure;insight;Integrins;Ligands;Link;Mediating;Mesenchymal;meter;Molecular;Mus;Natural regeneration;novel;Pathway interactions;Phase;Physiological;Positioning Attribute;Process;progenitor;Publishing;regenerative approach;regenerative therapy;Regulation;Reporter;Rest;Role;Science;Signal Transduction;Signaling Molecule;Skin;Smooth Muscle;Source;stem cell differentiation;stem cell fate;stem cell proliferation;stem cells;Study models;Testing;TGFB1 gene;tongue papilla;transcriptome;Transforming Growth Factor beta;Transposase;Work

PROJECT_TITLE: Regulation of catagen regression and progenitor pruning by the dermal sheath

STUDY_SECTION: ACTS

STUDY_SECTION_NAME: Arthritis, Connective Tissue and Skin Study Section[ACTS]


ADMINISTERING_IC: EY

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Diabetes;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences

ORG_DEPT: PHARMACOLOGY

PHR: RELEVANCE TO PUBLIC HEALTH The proposed research is relevant to public health because access to non-invasive (into the eye) treatment options for retinal inflammatory diseases are critically needed. The development of such therapeutics will address the limitations of current therapies and relieve the burden on health care systems worldwide, while improving patient compliance and quality of life.

PI_NAMEs: DUERFELDT, ADAM SCOTT (contact)

PROGRAM_OFFICER_NAME: SHEN, GRACE L

PROJECT_TERMS: Address;Affinity;Age related macular degeneration;aging demography;Agonist;analog;Angiogenesis Inhibitors;Animal Model;Antibodies;Apoptosis;Attenuated;attenuation;bevacizumab;Biochemical;Biological Assay;Biological Products;Blindness;Blood Vessels;burden of illness;Cell Culture Techniques;Cells;Cellular Assay;Clinical;Clinical Trials;clinically relevant;comorbidity;Complement;Complex;Complications of Diabetes Mellitus;Data;Derivation procedure;design;Development;Diabetes Mellitus;diabetic;diabetic patient;Diabetic Retinopathy;Disease;Dose Limiting;Down-Regulation;Drug Kinetics;Drug usage;efficacy evaluation;Endothelium;Epidemic;Etiology;Exhibits;Extravasation;Eye;Fenofibrate;Financial Hardship;Genetic;Health Expenditures;Healthcare Systems;Human;Hyperlipidemia;Impairment;improved;in silico;In Vitro;Inflammation;Inflammatory;Injections;innovation;Knowledge;Lead;lead optimization;Leukostasis;Lipids;meetings;Microsomes;Mitochondria;mitochondrial dysfunction;Modality;Modeling;Molecular;Nature;neovascularization;Nerve Degeneration;neuroprotection;novel;novel strategies;novel therapeutics;Operative Surgical Procedures;Oxidative Stress;Pathology;Patient Compliance;patient population;Patients;Pericytes;Peroxisome Proliferator-Activated Receptors;Persons;Pharmaceutical Preparations;pharmacologic;Population;Population Growth;PPAR alpha;Prevalence;Prevention;Production;programs;Property;prospective;protective effect;Protein Isoforms;Public Health;Quality of life;Refractory;Research;Research Design;response;Retina;Retinal Diseases;Retinal Neovascularization;retinal toxicity;Retinopathy of Prematurity;Role;Secondary to;small molecule;standard of care;Structure;success;synergism;systemic toxicity;Therapeutic;tool;Toxic effect;Type 2 diabetic;United States;Vascular Diseases;Vascular Endothelial Growth Factors;Vision

PROJECT_TITLE: Small Molecule PPAR-alpha Agonism as a Novel Approach to Treat Eye Vascular Diseases


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: ANN ARBOR

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE This long-standing training program produces scholars with the knowledge and tools of population science as well as specialized expertise from across the social sciences in areas vital to public health, including the foundations of healthy pregnancies, child and adolescent health and the transition to adulthood, and lifelong wellness. These scholars generate interdisciplinary understanding of potential intervention points to reduce health disparities in early and later life from positions in government, academia, and research and policy organizations.

PI_NAMEs: BURGARD, SARAH A. (contact)

PROGRAM_OFFICER_NAME: CAPPS, RANDOLPH CHRISTOPHER

PROJECT_TERMS: Population Study;Social Sciences;Training Programs

PROJECT_TITLE: Social Science Training Program in Population Studies


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: SAINT LOUIS

ORG_DEPT: PEDIATRICS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Overall Project Narrative Intellectual and Developmental Disabilities adversely affect 1 in 6 U.S. children and their families. The IDD Research Center at the Washington University School of Medicine (IDDRC@WUSTL) is a program that comprises three scientific core facilities, one dedicated to exploration of cellular and molecular mechanisms of causation in model systems of IDD, one dedicated to the identification of “signatures” of developmental disability through imaging of the developing brain, and one dedicated to specifying behavioral and genomic atypicalities in patients and translating new understanding of causal mechanisms into higher impact intervention.

PI_NAMEs: DOUGHERTY, JOSEPH D;GURNETT, CHRISTINA  (contact)

PROGRAM_OFFICER_NAME: PARISI, MELISSA

PROJECT_TERMS: Affect;Animal Model;autism spectrum disorder;Behavior;Behavioral;behavioral phenotyping;Biocompatible Materials;Bioinformatics;Biological Markers;Biological Models;Brain;Brain imaging;Caliber;Calibration;Cell Line;Cell model;Cells;Child;Clinical;clinical translation;Clinical Trials;cognitive neuroscience;cohort;Collection;Communities;Core Facility;Data;Data Set;Dedications;Derivation procedure;Development;Developmental Disabilities;Disability research;Disease;Disparate;Down's Syndrome;Electronic Health Record;Enrollment;Equipment and supply inventories;Etiology;Extramural Activities;Faculty;Familial disease;Family;follow-up;frontier;Functional disorder;functional genomics;Funding;gene discovery;Gene Dosage;Generations;Genes;Genetic;genetic variant;Genomics;Goals;Human;Image;imaging study;Individual;Infant;Institution;Intellectual and Developmental Disabilities Research Centers;Intellectual functioning disability;Interruption;Intervention;Investigation;Knowledge;Longitudinal Studies;medical schools;Methods;Molecular;Mothers;multiple omics;Natural History;neural;Neurodevelopmental Disability;neuroimaging;Neurosciences;new therapeutic target;novel;novel therapeutics;Pathogenesis;Pathway interactions;patient population;Patients;Phase;Phenotype;Population;premature;prevent;Prevention;preventive intervention;Productivity;programs;prospective;psychosocial;Qualifying;Quality of life;rare variant;Registries;Research;Research Infrastructure;Research Personnel;Research Project Grants;Resources;Risk;Rodent Model;Science;Scientist;Site;Specialized Center;Specific qualifier value;Standardization;Structure;success;Synapses;Syndrome;synergism;Therapeutic;Translating;Translational Research;Translations;United States National Institutes of Health;Universities;Variant;Washington;working group

PROJECT_TITLE: Washington University Intellectual and Developmental Disabilities Research Center


NIH_SPENDING_CATS: Genetics;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human

PHR: Project Narrative Understanding the extent to which and how hair follicle dermal stem cells regenerate the dermal sheath and contribute to the dermal papilla – both instructive niches for hair follicle stem cells and progenitors – is essential for developing future hair regenerative therapies. We will explore the functional requirement of hair follicle dermal stem cells for follicle regrowth, their lineage contribution to the papilla, and the molecular mechanisms that control their cell identity and potency.

PROJECT_TERMS: Ablation;adult stem cell;Apoptosis;base;Biological Process;Cell Lineage;Cell Physiology;Cell Separation;Cells;Cre driver;Data;Dedications;Dermal;Epithelial Cells;Essential Genes;experimental study;Fibroblasts;Functional Regeneration;Future;Gene Expression;Gene Expression Regulation;gene function;Genes;Genetic;genetic signature;Goals;Growth;Hair;Hair Cells;Hair follicle structure;Image;inducible Cre;Injury;insight;knockout gene;Knowledge;Label;Maps;Mediating;Mesenchymal;Mesenchymal Stem Cells;Modeling;Molecular;Molecular Profiling;Mus;Muscle Cells;Names;Natural Killer Cells;Natural regeneration;Physiological;Population;progenitor;regeneration potential;regenerative therapy;Regulation;Reporting;Rest;Resting Phase;Role;Signal Transduction;Skin;Smooth Muscle;Source;stem cell function;stem cell genes;stem cell niche;stem cell population;stem cell self renewal;stem cells;Technology;Testing;therapy development;Time;tongue papilla;tool;transcriptome;transcriptomics;Work;wound;wound healing

PROJECT_TITLE: Hair Follicle Dermal Stem Cell Functions and Potential


NIH_SPENDING_CATS: Brain Disorders;Disability Research;Down Syndrome;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Rare Diseases

PI_NAMEs: CONSTANTINO, JOHN N. (contact)

PROJECT_TERMS: Adult;Area;Attention;Behavioral;Biological Models;Brain;brain abnormalities;Child Care;Clinical;clinical translation;cohesion;Collaborations;Core Facility;cost effective;design;Development;Developmental Disabilities;Diagnosis;disability;Disparate;Down's Syndrome;Education;Ensure;Environment;Etiology;Evolution;Extramural Activities;Faculty;frontier;functional genomics;Funding;Future;Genetic;Genome;Human;improved;Individual;Infrastructure;Institution;Intellectual and Developmental Disabilities Research Centers;Intellectual functioning disability;Interruption;Investments;Knowledge;Laboratories;Leadership;member;Mental Health;Microcephaly;Mission;Missouri;Modeling;National Institute of Child Health and Human Development;Neurodevelopmental Disability;neuroimaging;Neurology;operation;Pathogenicity;Pediatrics;personalized medicine;Phase;Phenotype;post-doctoral training;Postdoctoral Fellow;premature;prevent;Prevention;Productivity;programs;Provider;Psychiatry;Research;research facility;Research Personnel;Research Training;Resources;Role;Science;Series;standard of care;Structure;System;Time;Training Programs;translational pipeline;Translations;United States National Institutes of Health;Universities;Washington;Zika Virus

PROJECT_TITLE: Administrative Core


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Genetics

ORG_CITY: OKLAHOMA CITY

ORG_NAME: OKLAHOMA MEDICAL RESEARCH FOUNDATION

ORG_STATE: OK

PHR: The vascular endothelium precisely interprets environmental cues and then signals through competing  pathways to promote either vessel quiescence or inflammation and remodeling. As such, many vascular  diseases result from metabolic disturbances or genetic mutations at key regulatory junctures. This  study will identify these decision-makinq elements and test their dvsrequlation in several qenetic  backgrounds

PI_NAMEs: COON, BRIAN GENE (contact)

PROGRAM_OFFICER_NAME: FRINCU, CRINA

PROJECT_TERMS: Binding;biological adaptation to stress;Blood flow;Blood Vessels;Body System;Cells;Complex;Coupling;Cues;Data;Defect;design;DNA Sequence Alteration;Elements;Endothelial Cells;Endothelium;experimental study;Genes;Genetic;Genetic Transcription;GLMN gene;GTF2H1 gene;Homeostasis;in vivo;Inflammation;Inflammatory;insight;Knock-out;Liquid substance;MADH2 gene;malformation;MAP Kinase Gene;MAPK7 gene;mechanotransduction;MEKKs;Metabolic;Metabolism;Mitochondria;mitochondrial dysfunction;Mitochondrial Proteins;mutant;Names;NF-kappa B;Oklahoma;Pathology;Pathway interactions;Phosphotransferases;Polyubiquitin;Proteins;proteotoxicity;reconstitution;Regulation;Research;response;Role;Scaffolding Protein;shear stress;Signal Transduction;Source;Testing;transcription factor;Ubiquitin;ubiquitin-protein ligase;Vascular Diseases;Vascular Endothelium

PROJECT_TITLE: Homeostatic regulation of endothelial mechanotransduction


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Down Syndrome;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Prevention

PI_NAMEs: GURNETT, CHRISTINA  (contact)

PROJECT_TERMS: Acceleration;Affect;Ally;antagonist;Award;Behavior;Behavioral;Biological Models;biomarker development;Brain;brain circuitry;Child Abuse;Childhood;Clinical;Clinical Data;Clinical Research;clinical translation;Clinical Trials;Clinical Trials Unit;Complement;Core Facility;cost;Data;data acquisition;Dedications;design;Development;Disability prevention;Disability research;Disease;early detection biomarkers;Early identification;Electrophysiology (science);Faculty;Family;follow-up;Fragile X Syndrome;Funding;Genes;Genetic;Genetic Counseling;Genome;genomic data;Genomics;Genotype;health determinants;Human;human subject;Impairment;Individual;Infant Development;Informatics;Infrastructure;innovation;Institution;Institutional support resources;Insurance;Intellectual and Developmental Disabilities Research Centers;Intellectual functioning disability;Intervention;Intervention Trial;Investments;K-Series Research Career Programs;Laboratories;Link;Medical;medical schools;Natural History;Near-Infrared Spectroscopy;Neurodevelopmental Disorder;neuroimaging;neuropsychiatry;novel strategies;Outcome;Pathogenesis;Pathogenicity;Patient observation;Patient Participation;patient population;Patient Recruitments;Patients;personalized intervention;Phenotype;Physicians;Populations at Risk;premature;prevent;Prevention;programs;psychosocial;Research;Research Personnel;Research Support;Resources;Risk;Role;Science;scientific hub;Secure;Services;Site;social;Structure;Syndrome;Technology;Testing;Therapeutic;Training;translational applications;Universities;Variant;visual tracking;Washington

PROJECT_TITLE: Clinical Translational Core


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: SAN FRANCISCO

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE The human genome produces many thousands of long noncoding RNA (lncRNA) molecules, and abnormal production of specific lncRNAs appears to underlie some of the most devastating human diseases such as cancer, Alzheimer’s disease, and schizophrenia. Discovering how lncRNAs regulate brain development is important to understanding how they may cause human disease. Furthermore, understanding how lncRNAs function at the molecular level is critical to the development of treatments that utilize lncRNAs as therapeutic targets.

PI_NAMEs: LIM, DANIEL A (contact)

PROGRAM_OFFICER_NAME: LEE, CRYSTAL ANNE

PROJECT_TERMS: Alzheimer's Disease;Bacterial Artificial Chromosomes;Biological Process;Brain;Cell Proliferation;cell type;Code;Communities;conditional knockout;Coupled;CRISPR interference;Data;data resource;Development;Developmental Delay Disorders;Disease;Drug Targeting;epigenomics;Genes;Genetic study;Genome;genome-wide;Goals;Human;Human Cell Line;human disease;Human Genome;human induced pluripotent stem cells;In Vitro;in vivo;Individual;induced pluripotent stem cell;insight;knock-down;Knowledge;Malignant Neoplasms;Maps;Mental disorders;Messenger RNA;Molecular;Molecular Genetics;Names;Nature;nerve stem cell;Nervous System Disorder;neural;Neurodegenerative Disorders;neurodevelopment;neurogenesis;Neurons;novel;Organoids;Outcome;Pathway interactions;Polypyrimidine Tract-Binding Protein;Production;Research;RNA Splicing;Role;Schizophrenia;single-cell RNA sequencing;Structure;Testing;therapeutic target;therapy development;Transcript;transcriptome;transcriptomics;transdifferentiation;Transgenes;Transplantation;Untranslated RNA;Work

PROJECT_TITLE: Functional long noncoding RNAs in neural development


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Down Syndrome;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Nonembryonic - Human

PI_NAMEs: MILBRANDT, JEFFREY D (contact)

PROJECT_TERMS: Affect;Apoptosis;ATAC-seq;Binding;Biological Assay;Biological Markers;Biological Models;Brain;Cell Line;Cell model;Cells;Cellular Assay;Child;Chromatin;chromatin remodeling;Clinical;clinical translation;Development;developmental disease;Diagnosis;Disease;disease-causing mutation;DNA Footprint;effective therapy;Emotional;endophenotype;Environmental Risk Factor;excitatory neuron;experimental study;Gene Expression Profile;gene repression;Genes;Genetic Heterogeneity;genetic risk factor;Genetic study;Genetic Transcription;genetic variant;Genome;Genome engineering;Genomics;Genotype;Goals;Human;human induced pluripotent stem cells;Image;Individual;induced pluripotent stem cell;Induced pluripotent stem cell derived neurons;inhibitory neuron;insight;Intellectual and Developmental Disabilities Research Centers;Intellectual functioning disability;knock-down;Length;loss of function;Measures;Methods;Molecular;Morphology;multiple omics;Mutation;nerve stem cell;neurite growth;Neurobiology;neurodevelopment;neuroimaging;Neuronal Differentiation;Neurons;new therapeutic target;novel;Pathogenesis;Pathogenicity;Pathology;Pathway interactions;patient subsets;Patients;Performance;Phase;Phenotype;phenotypic data;pluripotent stem cell differentiation;Population;Process;Proliferating;Protocols documentation;rare variant;Repression;Research Project Grants;Resources;response;Role;single-cell RNA sequencing;Site;Societies;stem cell differentiation;synaptogenesis;technology development;Therapeutic Intervention;therapeutically effective;Time;Transcriptional Regulation;Universities;Variant;Washington

PROJECT_TITLE: Connecting Rare Mutations to Common Pathways


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Down Syndrome;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Nonembryonic - Human

PI_NAMEs: WOZNIAK, DAVID FRANCIS (contact)

PROJECT_TERMS: Address;Animal Behavior;Animal Model;Animals;Area;Awareness;Behavior;Bioinformatics;Biological;Biological Markers;Biological Models;Brain;Brain imaging;Cell model;Clinical;Clinical Research;clinical translation;Complex;Consultations;data acquisition;Derivation procedure;Development;Disease;Electroencephalography;Emotional;Environmental Risk Factor;Evaluation;Event;Genetic;Genome;Genome engineering;genomic data;Genomics;Goals;Histologic;Human;Human Development;human disease;Human Genome;human model;human stem cells;Image;improved;Individual;induced pluripotent stem cell;insight;Institution;Intellectual and Developmental Disabilities Research Centers;Intellectual functioning disability;interest;Intervention;Learning;Link;medical schools;Memory;Mental Depression;Mission;model of autism spectrum disorder;model organism;Modeling;Molecular;Molecular Abnormality;Motivation;Motor;Mus;Mutation;neural;neural circuit;neurobehavioral;neuroimaging;neuropathology;neurophysiology;Neurosciences;novel marker;novel therapeutics;Pathology;Pathway interactions;patient registry;Patients;Phenotype;Physiology;Pre-Clinical Model;prevent;Process;programs;Rattus;recruit;Research Personnel;Resources;Rodent Model;role model;Scientist;Sensorimotor functions;Sensory;Services;Social Interaction;Somatic Cell;Somatosensory Evoked Potentials;Source;Stem Cell Research;Structure;synergism;Techniques;Technology;Testing;therapy development;Time;Universities;Washington;Work

PROJECT_TITLE: Model Systems Core


PHR: We have designed a clinical trial for women treated with drugs for early breast cancer before surgery, in which patients whose cancers do not respond to the initial experimental treatment can be switched to receive a different proven therapy that is considered the best for their particular type of cancer. Our goal is to develop a system that continuously improves our ability to provide each woman with the best chance at being cured, while also trying to avoid any unnecessary treatments that cause toxic side effects. This research program involves doctors and researchers from many different disciplines, as well as many patient advocates, to create a new type of clinical trial that puts patients needs front and center.

PI_NAMEs: ESSERMAN, LAURA J (contact);HYLTON-WATSON, NOLA M.

PROGRAM_OFFICER_NAME: KIM, BOKLYE

PROJECT_TERMS: Acceleration;Adjuvant Therapy;Advocacy;Advocate;Bioinformatics;Biological;Biological Markers;Biology;Biostatistics Core;Blood;Breast Cancer Risk Factor;Breast Cancer Treatment;Breast Magnetic Resonance Imaging;cancer type;Cessation of life;Circulation;Clinical Drug Development;clinical practice;Clinical Trials;Clinical Trials Design;Combined Modality Therapy;Communication;data resource;Dedications;design;Development;Discipline;Distant;Drug Combinations;drug development;Drug Targeting;druggable target;Early treatment;effective therapy;Elements;Enrollment;experience;Goals;high risk;Image;image archival system;imaging biomarker;Immune;Immune response;improved;improved outcome;In complete remission;Individual;individual patient;individualized medicine;Information Systems;Information Technology;Infrastructure;innovation;insight;intrinsic motivation;Laboratories;Leadership;Malignant Breast Neoplasm;Malignant Neoplasms;Measures;Molecular;molecular marker;Morbidity - disease rate;multidisciplinary;Nature;Neoadjuvant Therapy;Neoplasm Metastasis;next generation;non-invasive imaging;novel;novel therapeutics;operation;Operative Surgical Procedures;Outcome;Pathway interactions;Patients;personalized care;personalized medicine;Pharmaceutical Preparations;Phase;Phase II/III Trial;Population;precision medicine;predicting response;predictive marker;predictive modeling;prevent;Process;Productivity;programs;Quality of life;Randomized;Recurrence;Regimen;Research;Research Personnel;Residual Neoplasm;Resistance;Resource Sharing;Resources;response;response biomarker;Sampling;Selection for Treatments;Sequential Treatment;side effect;Site;Speed;success;System;Systems Integration;targeted agent;targeted biomarker;targeted treatment;Testing;Therapeutic;Time;Toxic effect;Translating;Translations;Treatment outcome;Treatment Protocols;treatment response;treatment strategy;trial design;tumor;Tumor Burden;unnecessary treatment;Waiting Lists;Woman;women's clinical trial;women's treatment;Work

PROJECT_TITLE: The I SPY 2.2 TRIAL: Evolving to Imaging and Molecular Biomarker Response Directed Adaptive Sequential Treatment to Optimize Breast Cancer Outcomes


NIH_SPENDING_CATS: Behavioral and Social Science;Biomedical Imaging;Breast Cancer;Cancer;Comparative Effectiveness Research;Genetic Testing;Genetics;Patient Safety;Precision Medicine;Women's Health Research

PHR: We have designed a clinical trial for women treated with drugs for early breast cancer before surgery, in which patients whose cancers do not respond to the initial experimental treatment can be switched to receive a different proven therapy that is considered the best for their particular type of cancer. We are able to do this by using medical imaging and core biopsies to monitor whether a treatment is working, and in this project, we are working improve our monitoring methods so that we can ensure each patient gets the treatment that is best for them, but is also spared the toxicity of treatments that aren’t working. We will also work to understand how to help doctors and patients discuss the results of the treatment response monitoring to help them make the best decisions about care together.

PI_NAMEs: DEMICHELE, ANGELA  (contact)

PROJECT_TERMS: Accelerated Phase;Acceleration;Address;Adverse event;Anthracycline;Anxiety;arm;Biological Markers;Breast Cancer therapy;breast imaging;Cancer Burden;cancer type;Caring;Cessation of life;Clinical;clinical decision-making;Clinical Drug Development;Clinical Treatment;Clinical Trials Design;Conduct Clinical Trials;confirmatory trial;Conflict (Psychology);Core Biopsy;cost;Decision Making;design;Development;Dimensions;Disease;Disease Outcome;Disease-Free Survival;Distant;Distant Metastasis;Distress;drug development;Early treatment;Eligibility Determination;Ensure;ERBB2 gene;Evaluation;exceptional responders;Functional Magnetic Resonance Imaging;Goals;high risk;Image;imaging biomarker;Immune checkpoint inhibitor;improved;improved outcome;In complete remission;Individual;individual patient;individual variation;individualized medicine;Infrastructure;innovation;Magnetic Resonance Imaging;Malignant Breast Neoplasm;Malignant Neoplasms;Measurement;Measures;Medical Imaging;Methods;molecular marker;Monitor;Neoadjuvant Therapy;next generation;novel;novel therapeutics;Operative Surgical Procedures;Outcome;Pathologic;Pathology;Pathology Report;Patient Outcomes Assessments;patient population;Patients;Perception;Personal Satisfaction;personalized medicine;Pharmaceutical Preparations;Pharmacotherapy;Phase;phase 2 testing;phase III trial;Physicians;Platinum;Population;precision medicine;predicting response;Prediction of Response to Therapy;Preparation;Process;programs;prospective;psychological outcomes;Randomized;randomized trial;Recommendation;Recurrence;Regimen;Regrets;Regulatory Pathway;Relapse;Reporting;Residual Cancers;response;response biomarker;Self Efficacy;Sequential Treatment;Series;shared decision making;Site;standard of care;success;Surrogate Markers;survival outcome;targeted biomarker;targeted treatment;Testing;therapy design;Time;tool;tool development;Toxic effect;treatment and outcome;treatment optimization;Treatment outcome;Treatment Protocols;treatment response;Treatment-related toxicity;trial design;triple-negative invasive breast carcinoma;tumor;tumor DNA;Tumor Volume;women's clinical trial;women's treatment;Work

PROJECT_TITLE: Project 1: Imaging, pathology, and molecular biomarkers to Optimize Treatment Switching within a SMART adaptive Framework


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Disability Research;Down Syndrome;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Rare Diseases

PI_NAMEs: SHIMONY, JOSHUA S (contact)

PROJECT_TERMS: Acceleration;animal imaging;Animals;Area;autism spectrum disorder;base;Brain;brain behavior;Child;Clinical;clinical care;Clinical Data;Clinical Research;Clinical Trials;cohort;Communities;computerized data processing;Consultations;cost efficient;Data;data acquisition;Data Analyses;data analysis pipeline;Data Linkages;design;Development;Developmental Disabilities;Disability research;Down's Syndrome;Ensure;Environment;Etiology;Evaluation;Faculty;flexibility;Funding;Genes;Genetic;Genomics;Goals;Grant;Human;human imaging;Image;imaging approach;imaging facilities;imaging system;Imaging Techniques;Infant;Informatics;Infrastructure;innovation;insight;Institution;Intellectual and Developmental Disabilities Research Centers;Intellectual functioning disability;International;Intervention;Investigation;Magnetic Resonance Imaging;Maps;Measurement;medical schools;Methodology;Methods;Modality;Motion;neural;neuroimaging;neuroinformatics;optical imaging;Optical Methods;Persons;Phenotype;Phenylketonurias;Physiologic pulse;preclinical imaging;preclinical study;Preparation;Protocols documentation;rapid growth;Research;Research Design;Research Personnel;research study;Resolution;Resources;Rest;Rodent;Sample Size;Sampling;Scanning;Science;Services;Specific qualifier value;Standardization;Structure;Talents;Technology;tool;Training;Translating;Tuberous Sclerosis;United States National Institutes of Health;Universities;Washington;Wolfram Syndrome

PROJECT_TITLE: Developmental Neuroimaging Core


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Clinical Research;Cystic Fibrosis;Genetics;Lung;Rare Diseases

ORG_CITY: BALTIMORE

ORG_DEPT: GENETICS

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE There are over 10 million cystic fibrosis (CF) carriers in the United States. Numerous studies indicate that a subset of CF carriers develop sinus and lung disease, similar to those with CF. The overall goal of this project is to determine if variation in CFTR function and/or presence of hypomorphic CFTR variants correlates with CF-like symptoms in CF carriers and if CFTR modulators might be effective treatment for symptomatic CF carriers.

PI_NAMEs: CUTTING, GARRY R (contact)

PROGRAM_OFFICER_NAME: EGGERMAN, THOMAS L

PROJECT_TERMS: Address;Affect;Age;Alleles;Amino Acid Substitution;autosome;carrier status;Cell Culture Techniques;Cells;Characteristics;Chlorides;Chronic Bronchitis;chronic rhinosinusitis;Clinic;Counseling;Cystic Fibrosis;cystic fibrosis patients;Cystic Fibrosis Transmembrane Conductance Regulator;Data;Delta F508 mutation;Detection;Disease;Drug Targeting;effective therapy;epidemiology study;Epithelial Cells;Exclusion;experience;Family;Family history of;Family member;Family Study;Frequencies;Genes;Genotype;Goals;grandparent;Individual;insight;Location;Lung Diseases;Measurement;Medical;Mendelian disorder;Modeling;Molecular;Molecular Genetics;monolayer;Nasal Epithelium;Parents;Phase;Population;prenatal testing;Proteins;Questionnaires;Race;recruit;Reporting;respiratory;Respiratory Signs and Symptoms;response;RNA Splicing;sex;Siblings;Side;Sinus;Site;symptom treatment;Symptoms;Testing;Uncertainty;United States;Variant;VX-770

PROJECT_TITLE: Molecular Genetics of Cystic Fibrosis

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Clinical Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: BILLINGS

ORG_DEPT: BIOLOGY

ORG_NAME: MONTANA STATE UNIVERSITY -BILLINGS

ORG_STATE: MT

PHR: Project Narrative The Atomic Circus Experience (ACE) Project has the goal of exposing students and the communities of Eastern Montana to STEM and biomedical concepts and careers, helping them recognize and understand the pathways to future biomedical employment. The ACE goal is accomplished through collaborations with local educators, biomedical professionals, and community members to develop a customized multimedia biochemistry stage show, as well as culturally relevant, place-based STEM curriculum. The curriculum engages students with local community members involved in biomedical and STEM work, the show ignites a passion for learning which then paves the way for solving local issues using biochemical and STEM skills and knowledge.

PI_NAMEs: OBERY, AMANDA ;QUEEN, MATTHEW  (contact)

PROGRAM_OFFICER_NAME: FAUPEL-BADGER, JESSICA

PROJECT_TERMS: 3-Dimensional;Area;Area Health Education Centers;aspirate;Attitude;Awareness;Basic Science;Biochemical;Biochemistry;Biomedical Research;career;Career Choice;Collaborations;Communities;community center;community engagement;COVID-19;Data;design;Development;Education;Educational Curriculum;Educational workshop;Employment;Ensure;Event;experience;Faculty;fifth grade;Focus Groups;Future;General Population;Goals;holistic approach;Hour;improved;innovation;interest;Interview;junior high school;Knowledge;Learning;learning outcome;Location;member;Modeling;Montana;Multimedia;Next Generation Science Standards;Pathway interactions;pedagogy;Persons;Play;Problem-Based Learning;Research;Research Personnel;Resources;Role;role model;Rural;Rural Community;school district;Schools;Science;Science, Technology, Engineering and Mathematics Education;skills;STEM career;STEM curriculum;STEM field;STEM research;student participation;Students;success;Surveys;teacher;Testing;Travel;tribal community;Underserved Population;urban area;Work

PROJECT_TITLE: Authentic Community Engagement in Science (ACES)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(56)R]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Breast Cancer;Cancer;Genetic Testing;Genetics;Precision Medicine;Prevention;Women's Health Research

PHR: Tumor response measured by breast MRI is used in the response-adaptive design of the I-SPY2 trial to quickly evaluate the effectiveness of new treatments. During the past funding cycle we developed MRI methodologies to assess response at the patient level to identify patients on trajectories to poor or exceptional response. Project 2 focuses on improving the accuracy of imaging biomarkers for informing early treatment switching decisions and contributing to prognostic modeling of long-term outcomes.

PI_NAMEs: HYLTON-WATSON, NOLA M. (contact)

PROJECT_TERMS: Address;Algorithms;Area;arm;Beds;Biological Markers;biomarker development;Biopsy;Breast;Breast Cancer Treatment;Breast Magnetic Resonance Imaging;Cancer Burden;Classification;Clinical;Clinical Drug Development;cohort;contrast enhanced;Core Biopsy;Data;Decision Modeling;Dedications;design;Disease;Disease-Free Survival;drug development;drug efficacy;Drug Evaluation;Early Diagnosis;Early treatment;effectiveness evaluation;Elements;Eligibility Determination;Endocrine;ERBB2 gene;Estrogen receptor positive;Evaluation;Funding;Goals;Heterogeneity;Histopathology;hormone receptor-positive;Image;imaging biomarker;imaging modality;improved;In complete remission;Individual;individual patient;individualized medicine;Kinetics;Label;Magnetic Resonance Imaging;Malignant Breast Neoplasm;Mammary Neoplasms;Measurement;Measures;Methodology;Modeling;Molecular;molecular marker;molecular subtypes;Negative Finding;Neoadjuvant Therapy;next generation;Nodal;non-invasive imaging;Normal tissue morphology;novel;Operative Surgical Procedures;Outcome;participant enrollment;Pathologic;Pathology;patient subsets;Patients;Performance;personalized medicine;Pharmaceutical Preparations;Phase;Positron-Emission Tomography;predicting response;predictive marker;predictive modeling;Probability;prognostic;Prognostic Marker;prognostic model;programs;Protocols documentation;quantitative imaging;radiomics;radiotracer;Randomized;Recommendation;Regimen;relapse risk;Research Personnel;Residual Cancers;response;response biomarker;Retrospective Studies;Sequential Treatment;Serial Magnetic Resonance Imaging;Shapes;Signal Transduction;Standardization;success;targeted biomarker;Testing;Time;tool;Training;treatment arm;treatment effect;Treatment Protocols;treatment response;trial design;tumor;tumor DNA;tumor heterogeneity;Tumor Volume;Tumor-Derived;Update;uptake;Widespread Disease

PROJECT_TITLE: Project 2: Non-invasive imaging metrics to optimize early treatment switching decisions and prognostic modeling of long-term outcomes


ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE The new application requests funding to support predoctoral training in Biochemistry, Cell and Developmental Biology at Emory University. The proposal will replace the current, highly successful, training program that is currently in its 29th year, which had already incorporated quantitative training, evidenced-based learning approaches, formal scientific writing, training for faculty mentors and career/professional development. The new proposal builds on the strengths of the current program while adding new innovative approaches for enhancing training in rigor and reproducibility as well as novel methods for assessing student competencies in core areas important for the training of a diverse biomedical research workforce.

PI_NAMEs: BOISE, LAWRENCE H. (contact);CORBETT, ANITA H.

PROGRAM_OFFICER_NAME: JONES, LATAISIA CHERIE

PROJECT_TITLE: Training Program in Biochemistry, Cell and Development Biology

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - A[TWD-A]


NIH_SPENDING_CATS: Biomedical Imaging;Biotechnology;Breast Cancer;Cancer;Cancer Genomics;Genetic Testing;Genetics;Human Genome;Patient Safety;Precision Medicine;Prevention;Women's Health Research

PHR: In women treated with drugs for early breast cancer before surgery, the best result is when the tumor completely disappears, because this means the risk of the cancer returning is greatly reduced. In this project, we use genomics and medical imaging to look for signs that will help us determine if a treatment is working or not. We are also working to understand the biology of why some cancers are difficult to treat and look for ways that might make them vulnerable to other treatments.

PI_NAMEs: VAN'T VEER, LAURA J (contact)

PROJECT_TERMS: Alternative Therapies;Biological Markers;Biology;Blood;Breast Cancer Treatment;burden of illness;cancer risk;cancer subtypes;Caring;Cessation of life;Characteristics;chemokine;chemotherapy;Circulation;clinical decision-making;Clinical Drug Development;Clinical Treatment;Collaborations;Combined Modality Therapy;Cyclophosphamide;cytokine;Data;design;Development;DNA Sequence Alteration;Doxorubicin;druggable target;Early identification;Epidermal Growth Factor Receptor;exome sequencing;exosome;Gene Expression;Gene Rearrangement;Genomics;Goals;Grant;high risk;Hormone Receptor;Human;Image;imaging biomarker;Immune;immune imaging;Immunofluorescence Immunologic;improved;In complete remission;Individual;innovation;liquid biopsy;Magnetic Resonance Imaging;Malignant Breast Neoplasm;Malignant Neoplasms;Measures;Medical Imaging;Messenger RNA;Metastatic/Recurrent;Modality;Modeling;Molecular;Molecular Analysis;molecular marker;multiple omics;Neoadjuvant Therapy;next generation;novel;novel therapeutics;Operative Surgical Procedures;Outcome;Paclitaxel;Pathologic;Pathway interactions;patient population;Patients;personalized medicine;Pharmaceutical Preparations;Phase;phase III trial;Phenotype;Phosphoproteins;predicting response;prediction algorithm;Prediction of Response to Therapy;predictive modeling;Prognosis;programs;Protein Analysis;Proteins;rational design;Recurrence;Regimen;Research;Residual Neoplasm;Resistance;Resources;response;response biomarker;Risk;Running;Sequential Treatment;standard of care;Stratification;success;targeted agent;targeted biomarker;Technology;Testing;Therapeutic;therapy design;therapy resistant;Time;Treatment Protocols;treatment response;tumor;Tumor Biology;tumor-immune system interactions;Woman;women's treatment;Work

PROJECT_TITLE: Project 3: Characterization of the biology of non-responders using Imaging and molecular analysis to inform treatment


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Mental Health;Neurosciences

ORG_CITY: PITTSBURGH

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Dispositional negativity is a transdiagnostic risk factor for psychopathology defined by a heightened reactivity to threat and punishment that manifests in the form of frequent and intense negative affect. The present application leverages the capabilities of modern computational neuroscience to examine the latent decision processes that contribute to maladaptive threat responding in individuals with elevated dispositional negativity. Understanding the neurocomputational basis of dispositional negativity will help to facilitate the development of behavioral and computational indices that can be targeted for modification in novel transdiagnostic interventions.

PI_NAMEs: ALLEN, TIMOTHY A (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: active control;Adult;Aggressive behavior;Amygdaloid structure;Anger;Anxiety;anxious;Aversive Stimulus;Behavior;Behavior Control;Behavioral;Behavioral inhibition;Behavioral Paradigm;behavioral response;Biological;Clinical;clinical development;clinical predictors;clinical prognosis;Cognitive;Complex;computational neuroscience;Computer Models;conditioning;cost;Cues;Decision Making;Decision Theory;Depressed mood;Desire for food;Development;Diagnosis;Diagnostic;Dimensions;Disease;Distal;Distress;Economic Burden;Economics;Emotional;Environment;Equation;experimental study;flexibility;Frustration;Functional impairment;Functional Magnetic Resonance Imaging;functional outcomes;Future;Goals;Hostility;imaging modality;Impairment;improved;indexing;Individual;Individual Differences;Interpersonal Relations;Intervention;Label;Laboratories;Learning;Link;Literature;Maintenance;Measures;Mental disorders;Mentors;Methods;Modeling;Modernization;Motivation;multilevel analysis;National Institute of Mental Health;negative affect;neural;neural circuit;neurobehavioral;neuroimaging;Neurosciences;Neurotic Disorders;novel;Operant Conditioning;Outcome;Participant;Pattern;Phenotype;Process;Protocols documentation;psychiatric comorbidity;psychologic;Psychological reinforcement;Psychometrics;Psychopathology;Punishment;recruit;Recurrence;Relapse;Research;Research Domain Criteria;Research Support;response;Risk Factors;Sampling;Series;Signal Transduction;Site-Directed Mutagenesis;skills;social;Stimulus;Symptoms;System;Testing;Training;treatment response;Variant;Ventral Striatum;vigilance;Work

PROJECT_TITLE: Dispositional Negativity and the Pavlovian Control of Active and Passive Defensive Behavior

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Genetics;Infectious Diseases;Rare Diseases

ORG_CITY: CLEMSON

ORG_NAME: CLEMSON UNIVERSITY

ORG_STATE: SC

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it investigates a critical segment of the infection cycle of Entamoeba histolytica, which causes an estimated 100 million cases of amoebic dysentery each year worldwide and is a major public health problem in many developing countries. We have developed a method for producing infectious cysts in the laboratory and can now capitalize on this major advancement to study how E. histolytica senses and responds to environmental signals to form cysts to continue the cycle of infection. This understanding provides a critical foundation for developing mechanisms targeting this stage of infection as a way to reduce the spread of this disease pursuant to part of the NIH’s mission.

PI_NAMEs: INGRAM-SMITH, CHERYL JEAN (contact)

PROGRAM_OFFICER_NAME: MCGUGAN, GLEN C

PROJECT_TERMS: Acetate-CoA Ligase;Acetates;Amebic colitis;Amebic Liver Abscess;Back;Bioinformatics;biological adaptation to stress;Candidate Disease Gene;candidate identification;Carrier State;Cell Density;Cell Wall;Cells;Cessation of life;Chitin;Coenzyme A;contaminated water;Cues;Cyst;Data;deprivation;Developing Countries;Disease;Distant;Entamoeba histolytica;Entamoeba invadens;Environment;excystation;Expression Library;Food Contamination;Foundations;Gene Expression Profiling;Gene Library;Gene Silencing;Genes;Genetic;Glucose;Goals;Growth;Heat Stress;Human;human pathogen;In Vitro;Infection;Ingestion;interest;Investigation;Knowledge;Laboratories;Laboratory culture;Large Intestine;Libraries;Mediating;Methods;Mission;Motility;nitrosative stress;overexpression;Oxidative Stress;Parasites;pathogen;Persons;Physiological;Play;prevent;Process;programs;Propionates;Protocols documentation;Public Health;Regulation;Regulator Genes;Reproducibility;Reptiles;Research;response;Role;Sampling;Scientist;screening;Signal Pathway;Signal Transduction;Small Intestines;Stimulus;Stress;System;Technology;thioester;Time;transcription factor;transcriptome sequencing;Translating;United States National Institutes of Health;Volatile Fatty Acids

PROJECT_TITLE: Identification and characterization of early encystation genes in the human parasite Entamoeba histolytica

STUDY_SECTION: PTHE

STUDY_SECTION_NAME: Pathogenic Eukaryotes Study Section[PTHE]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Rare Diseases;Vector-Borne Diseases;West Nile Virus

ORG_CITY: DAVIS

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: St. Louis encephalitis virus (SLEV) is a mosquito borne pathogen that causes febrile illness and sometimes fatal encephalitis that reemerged and spread in the Western US from 2015-2021. Given that reemergence can be facilitated by changing viral fitness, the goal of this project is to assess the extent by which SLEV reemergence is promoted by augmented infectivity and transmissibility compared to historical strains in avian and mosquito cells and Culex mosquito vectors. The project is significant in that it will define how SLEV has reemerged in a novel landscape where related West Nile virus is now endemic and information learned from it can be used to improve targeted vector control to reduce SLEV disease in people.

PI_NAMEs: COFFEY, LARK L (contact)

PROGRAM_OFFICER_NAME: GAUTAM, RAJEEV

PROJECT_TERMS: Area;Arizona;Biological Assay;Birds;Blood;California;Cell Culture Techniques;Cells;Competence;Complement;County;Culex (Genus);Culex pipiens;Culicidae;Disease;Disease Outbreaks;Dose;Ducks;Embryo;Encephalitis;enhancing factor;Environment;enzootic;Epidemic;Exhibits;Extinction;Fever;Fibroblasts;fitness;Flavivirus;Genetic;Genetic study;Genotype;Geography;Goals;Herd Immunity;Human;human pathogen;Immunity;improved;Incubated;Infection;Infectious Encephalitis;Ingestion;Invaded;Learning;Measures;Mediating;mosquito-borne;mosquito-borne pathogen;novel;novel strategies;Pattern;Persons;Play;Process;Resource Allocation;Role;Saliva;Sampling;South America;St. Louis Encephalitis Virus;Testing;Time;Tissues;transmission process;vector;vector competence;vector control;vector mosquito;Viral;viral fitness;viral RNA;viral transmission;Virus;Virus Diseases;virus genetics;West Nile viral infection;West Nile virus

PROJECT_TITLE: Transmission dynamics and fitness of reemerging St. Louis encephalitis virus

STUDY_SECTION: VB

STUDY_SECTION_NAME: Vector Biology Study Section[VB]


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Lung;Lung Cancer;Prevention;Rare Diseases

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: PROJECT NARRATIVE Lung adenocarcinoma (LUAD), even when detected in its early stages, exhibits very poor prognosis warranting continued improvements for its treatment. Efforts to treat LUAD are stymied by our poor understanding of how the tumor early on emerges from the complex lung ecosystem. Using unique and richly annotated human cohorts, experimental mouse models that faithfully recapitulate the disease, as well as state-of-the-art technologies that sequence individual cells and mathematical modeling, the proposed work seeks to unravel how LUAD develops across space and time, thus providing a foundation for developing new strategies for interception of this fatal disease.

PI_NAMEs: KADARA, HUMAM  (contact);WANG, LINGHUA

PROGRAM_OFFICER_NAME: DUECK, HANNAH RUTH

PROJECT_TERMS: Acceleration;Address;Atlases;B cell clonality;B-Cell Antigen Receptor;B-Lymphocytes;Cell Communication;Cell model;Cells;Cessation of life;Clinical;cohort;Communities;Complex;Copy Number Polymorphism;Data;data portal;Development;Diagnosis;Dimensions;Disease;Disease Outcome;Distant;Early Diagnosis;Early treatment;Ecosystem;Epithelium;Event;Evolution;Exhibits;Foundations;Heterogeneity;Human;Immune;Immunologic Receptors;immunological intervention;Immunotherapy;improved;in vivo;Individual;Inflammatory;Knowledge;Lesion;Lung;Lung Adenocarcinoma;lung development;lung lesion;machine learning model;Malignant - descriptor;Malignant neoplasm of lung;Malignant Neoplasms;Maps;mathematical model;Modeling;Molecular;mouse model;Mus;Mutation;Mutation Analysis;neoplastic;Normal Cell;Normal tissue morphology;novel therapeutic intervention;Pathogenesis;Pathologic;Pathologic Processes;patient subsets;Patients;Performance;Phenotype;Physiological Processes;Population;premalignant;Prevention strategy;Probability;Prognosis;programs;Property;Receptor Cell;Recurrence;RNA;Role;single cell sequencing;single cell technology;Site;Smoking;Somatic Mutation;spatiotemporal;Structure of parenchyma of lung;Technology;Testing;Time;Training;transcriptome sequencing;transcriptomics;treatment strategy;tumor;tumor heterogeneity;Tumor Stem Cells;tumor-immune system interactions;Work

PROJECT_TITLE: Spatial and temporal tumor-immune co-evolution and interactions that model lung adenocarcinoma development


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetic Testing;Genetics;Human Genome;Immunotherapy;Precision Medicine;Prevention

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: It has long been recognized that tumors are highly heterogeneous with no two tumors sharing the same set of mutations. By analyzing inherited (germline) and tumor-specific (somatic) genetic variants that co-occur in tumors, we will investigate the mechanisms by which the inherited genome drives heterogeneous disease risk, progression, and clinical outcome. This proposal will develop novel bioinformatics tools and strategies for analysis of large-scale genomics datasets and apply them to a compendium of tumor genomics data to reveal and characterize germline-somatic interactions.

PI_NAMEs: ALEXANDROV, LUDMIL B;CARTER, HANNAH KATHRYN (contact)

PROGRAM_OFFICER_NAME: NELSON, STEFANIE A

PROJECT_TERMS: Address;Adult;Affect;Age;Age of Onset;anti-cancer research;Attention;Bioinformatics;bioinformatics pipeline;bioinformatics tool;Cancer Biology;cancer genome;cancer genomics;cancer predisposition;cancer prevention;cancer risk;cancer therapy;Cell Physiology;Clinical;clinical phenotype;clinically relevant;Communities;Computer software;computing resources;Data;Data Set;design;Detection;Development;Diagnosis;Disease;disorder risk;DNA Repair;Drug Screening;Early Diagnosis;Event;Evolution;exome;fitness;Gene Expression Regulation;Genes;Genetic;genetic profiling;genetic variant;Genetic Variation;Genome;genomic data;genomic profiles;Genomics;Germ Lines;Germ-Line Mutation;Goals;Heterogeneity;Human;Immune;Immune system;Immunity;Immunologic Surveillance;Immunotherapy;Individual;Inherited;insight;inter-individual variation;Inter-tumoral heterogeneity;Literature;loss of function;Malignant Childhood Neoplasm;Malignant Neoplasms;meetings;Molecular;molecular phenotype;Morbidity - disease rate;mortality;Mutagenesis;Mutation;Mutation Analysis;Nature;neoplastic cell;next generation sequencing;Normal tissue morphology;novel;Oncogenes;Oncogenic;Online Systems;Outcome;Pathway interactions;Patients;Pattern;Penetrance;personalized intervention;Population;Prevention therapy;Process;Prognosis;Progression-Free Survivals;Research;Research Personnel;Resources;response;Retinoblastoma;risk variant;Role;Sample Size;Selection Criteria;Shapes;Signal Pathway;Somatic Mutation;Source;Statistical Methods;success;Survival Rate;targeted treatment;Technology;Testing;tool;treatment response;tumor;Tumor Biology;tumor progression;Tumor Suppressor Proteins;tumorigenesis;Validation;Variant;whole genome

PROJECT_TITLE: Comprehensive identification of germline-somatic interactions

STUDY_SECTION: CG

STUDY_SECTION_NAME: Cancer Genetics Study Section[CG]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Precision Medicine;Women's Health Research

PHR: The Communications, Administration, Advocacy and Project management (CAAP) Core will provide administrative support to help coordinate, organize and project manage the extensive collaborations that take place in this program project. The CAAP Core will ensure measurable achievement of deliverables by the Project teams within timeline and budget restraints, and work with the study sponsor’s clinical operations group to help translate program project research deliverables into the I-SPY2.2 trial. Importantly, the CAAP Core works to engage our team of patient advocates and ensure that they are integrated into all the projects and teams to bring their unique and important perspective to this program project and its goals.

PI_NAMEs: ESSERMAN, LAURA J (contact)

PROJECT_TERMS: Achievement;Advocacy;Advocate;Breast Cancer Treatment;Budgets;Clinical;Clinical Drug Development;Collaborations;Communication;design;Elements;Ensure;Friends;Generations;Goals;Human Resources;imaging biomarker;improved;Individual;Infrastructure;Leadership;Magnetic Resonance Imaging;Malignant Breast Neoplasm;Measurable;Measures;meetings;Methodology;Modification;molecular marker;next generation;novel;Office of Administrative Management;operation;Outcome;Participant;Patient-Focused Outcomes;Patients;personalized medicine;Program Research Project Grants;programs;Protocols documentation;Regimen;Regulatory Pathway;Reporting;Research Personnel;response biomarker;restraint;Role;Science;Sequential Treatment;Specific qualifier value;Structure;Subgroup;timeline;tool;Training;Translating;Translational Research;treatment response;treatment strategy;trial design;webinar;Work;working group

PROJECT_TITLE: Core 3: Communications, Administrations, Advocacy, and Project Management


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Mental Health;Neurosciences;Pediatric;Social Determinants of Health;Substance Misuse;Underage Drinking;Women's Health Research

PHR: PROJECT NARRATIVE There is a normative decrease in problem alcohol use that occurs in the mid-20s, after binge and heavy drinking peak, a process that is called “maturing out”; while most young adults mature out of problem use, a subset of individuals persist or escalate their drinking. The proposed study will use functional magnetic resonance imaging to identify structural and task activation patterns predictive of alcohol desistence and persistence during the maturing out period in order to provide important information about those who are at the greatest risk. Such mechanistic knowledge is critical for downstream research, such as the development of targeted interventions to mitigate the emergence of alcohol use disorders, and the development of efficacious treatment tailored specifically for those who do not mature out of problem alcohol use.

PI_NAMEs: HARDEE, JILLIAN ELIZABETH (contact)

PROGRAM_OFFICER_NAME: GRAKALIC, IVANA

PROJECT_TERMS: Accounting;Adolescent and Young Adult;Age;Alcohol abuse;Alcohol consumption;alcohol cue;alcohol effect;alcohol risk;alcohol use disorder;Alcohols;Amygdaloid structure;Anxiety;Behavior;behavior prediction;Behavioral Mechanisms;binge drinker;binge drinking;Brain;cognitive control;coping;cue reactivity;Cues;Data;Data Analyses;Data Collection;design;Development;Disinhibition;drinking;Drug usage;efficacious treatment;emerging adulthood;emotion dysregulation;emotion regulation;Emotional;Emotions;Esthesia;executive function;Female;follow up assessment;follow-up;Functional Magnetic Resonance Imaging;functional MRI scan;Gender;Heavy Drinking;Image;improved;improved outcome;Impulsivity;Individual;individualized medicine;Intervention;Knowledge;lifetime risk;Limbic System;Magnetic Resonance Imaging;male;Marriage;Measurement;Measures;men;Mental Depression;Methods;Modeling;multimodality;neural;neural patterning;neurobehavioral;Neurobiology;neurodevelopment;neuroimaging;neuromechanism;Neuropsychology;neurotoxic;novel;Outcome;Participant;Patient Self-Report;Pattern;Play;predictive marker;problem drinker;Process;psychosocial;Psychosocial Assessment and Care;recruit;Relapse;Reporting;Research;resilience;Resolution;response;Rest;Rewards;Risk;Risk Behaviors;Risk Factors;Role;Sampling;Scanning;sex;Sex Differences;Social Environment;stem;Structure;System;Testing;Time;Woman;young adult

PROJECT_TITLE: Neural mechanisms of maturing out of problem alcohol use

STUDY_SECTION: ARM

STUDY_SECTION_NAME: Addiction Risks and Mechanisms Study Section[ARM]


NIH_SPENDING_CATS: Bioengineering;Breast Cancer;Cancer;Cancer Genomics;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Patient Safety;Precision Medicine;Women's Health Research

PHR: The IT and Systems Integrations Core will manage and support the data and bioinformatics infrastructure needs of the four projects. Specific aims include support for return of results at point of care, collection and processing of electronic patient reported outcomes (ePRO), and integration of pathology and biomarker data as source classifiers. The core team is deeply integrated into the I-SPY2.2 trial and will continually receive requirements and feedback to enhance IT platforms ensuring the Project needs are met.

PI_NAMEs: ASARE, ADAM  (contact)

PROJECT_TERMS: Address;Adverse event;Architecture;Bioinformatics;bioinformatics infrastructure;Biological Markers;Case Report Form;Case Study;Clinical;clinical research site;Code;cohort;Collection;Common Terminology Criteria for Adverse Events;Data;Data Analyses;data infrastructure;data sharing;Data Sources;Databases;design;Development;Documentation;electronic data;electronic data capture system;Electronic Health Record;electronic patient reported outcomes;Ensure;exome;experience;Feedback;Goals;Grant;Hybrids;Image;imaging biomarker;Immune;improved;Individual;Information Systems;Information Technology;Infrastructure;innovation;Internet;Laboratories;Machine Learning;Magnetic Resonance Imaging;Maintenance;Malignant Breast Neoplasm;member;migration;molecular marker;Nature;Outcome;Pathology;personalized care;Physicians;point of care;portability;programs;Quality of life;Randomized;Reporting;repository;Reproducibility of Results;Research;Research Personnel;Resources;response biomarker;Science;Secure;Sequential Treatment;Services;shared repository;Source;statistics;Surveys;symposium;System;Systems Biology;Systems Integration;Technology;The Cancer Genome Atlas;Time;tool;Toxic effect;transcriptome sequencing;treatment response;Validation;Visualization;web services;Work

PROJECT_TITLE: Core 1: Information Technology and Systems Integration


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Child Abuse and Neglect Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Violence Research;Youth Violence

ORG_CITY: UNIVERSITY PARK

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

PHR: PROJECT NARRATIVE The proposed project will examine the implications of parental incarceration for children’s health and wellbeing from birth into early adulthood. Following a statewide birth cohort in multiple linked data systems, we will apply rigorous methodological approaches to assess the effects parent incarceration over time, and the implications of these effects vis-à-vis persistent racial inequalities. Project findings will inform efforts to reform carceral penalties and mitigate adverse outcomes for children.

PI_NAMEs: FONT, SARAH  (contact)

PROGRAM_OFFICER_NAME: CHINN, JUANITA JEANNE

PROJECT_TERMS: Address;Adolescence;Adult;adverse outcome;Age;Asian;Attention;Birth;Black American;Black race;Caregivers;Characteristics;Charge;Child;Child Abuse and Neglect;Child Development;Child Health;Child Support;Child Welfare;Childhood;Cognitive;cohort;Communities;Compensation;Consensus;Criminal Justice;Data;Development;Disparity;early childhood;Economics;Education;emerging adult;Employment;Environment;ethnic disparity;Ethnic Origin;examination questions;exhaust;experience;Exposure to;Face;Family Characteristics;Fathers;foster care;foster home;General Population;Health;health assessment;health disparity;high risk;Hispanic;Hispanic Americans;Home;Imprisonment;improved;Income;Inequality;Information Systems;insight;interest;intergenerational;Jail;Knowledge;Length;Life;Link;Literature;Living Arrangement;Low income;Measures;Mental Health;Methodology;Modeling;Native Americans;neglect;neighborhood disadvantage;Outcome;Parents;Patient Self-Report;Personal Satisfaction;Persons;Pharmaceutical Preparations;physical conditioning;Policies;Population;population based;Positioning Attribute;Poverty;Pregnancy;Pregnancy in Adolescence;Prisons;Program Development;Race;racial disparity;Recording of previous events;Records;Research;residence;Resources;risk mitigation;Role;Sample Size;Sampling;Selection Bias;social;social adversity;Social Environment;Social Work;Surveys;System;Testing;Time;Violence;Wisconsin;young adult;Youth

PROJECT_TITLE: Implications of Parental Incarceration for Child Health and Wellbeing

STUDY_SECTION: SSPA

STUDY_SECTION_NAME: Social Sciences and Population Studies A Study Section[SSPA]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Genetic Testing;Genetics;Precision Medicine;Women's Health Research

PHR: The Bioinformatics and Biostatistics core is a comprehensive resource for advanced adaptive clinical trial design and multi-omic biomarker data analysis and synthesis within the I-SPY2.2 Program Project. We will work closely with each of the project teams to provide project-specific analytical support, as well as facilitate cross-project analyses, to ensure that analyses conducted are consistent across projects and apply the highest standards of statistical rigor.

PI_NAMEs: YAU, CHRISTINA  (contact)

PROJECT_TERMS: Address;Algorithms;Award;Bioinformatics;Biological Markers;Biology;Biometry;Biostatistics Core;Cancer Burden;Clinical Trials Design;clinically actionable;Complex;Data;Data Analyses;Data Storage and Retrieval;Decision Modeling;Dedications;Early treatment;Ensure;Generations;Goals;high standard;high throughput analysis;Image;imaging biomarker;Individual;Information Systems;Information Technology;innovation;Internet;Malignant Breast Neoplasm;Measures;member;Methodology;Methods;Modality;Molecular;Molecular Analysis;molecular marker;Molecular Profiling;Multiomic Data;multiple omics;non-invasive imaging;novel;Outcome;Pathology;Patients;Pharmaceutical Preparations;predictive modeling;prognostic model;programs;Quality of life;Regimen;Reproducibility of Results;Research Personnel;Residual Cancers;Resource Allocation;Resources;response;response biomarker;Sequential Multiple Assignment Randomized Trial;Sequential Treatment;Services;Statistical Models;statistics;symposium;System;Systems Integration;Testing;timeline;transmission process;treatment optimization;trial design;Woman;Work

PROJECT_TITLE: Core 2: Bioinformatics and Biostatistics


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Complementary and Integrative Health;Digestive Diseases;Emerging Infectious Diseases;Infectious Diseases;Microbiome;Nutrition

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: PROJECT NARRATIVE C. difficile infection (CDI) is the most common cause of antibiotic-induced diarrhea. Anti-C. difficile antibiotic is associated with recurrent CDI. This proposal will test whether nutritional supplementation with alanyl-glutamine, in addition to standard treatment, can reduce intestinal inflammation, recurrence, and deaths from CDI.

PI_NAMEs: WARREN, CIRLE ALCANTARA (contact)

PROGRAM_OFFICER_NAME: RANALLO, RYAN

PROJECT_TERMS: Adult;Aftercare;Age;Animals;Antibiotic Therapy;antibiotic-associated diarrhea;Antibiotics;antimicrobial;Apoptosis;Body Weight decreased;CASP8 gene;Cell Line;cell motility;Cell Proliferation;Cells;Cessation of life;Child;Clinical Trials;Clostridium;Clostridium difficile;Comparative Effectiveness Research;comparison control;cost;Data;Death Rate;Diarrhea;Dipeptides;Disease;Dose;Double-Blind Method;double-blind placebo controlled trial;dysbiosis;Ensure;Epidemiology;Gastroenterology;Geriatrics;Glutamine;Growth;gut inflammation;gut microbiota;healthcare-associated infections;Histopathology;Hospitalization;Human;human disease;human old age (65+);Immunocompromised Host;Impairment;improved;improved outcome;In Vitro;in vivo;Incidence;Infection;Inflammation;Inflammatory;Inflammatory Response;Injury;innovation;Intervention;intestinal barrier;intestinal epithelium;Intestinal Secretions;Intestines;Mediating;metabolic profile;metabolomics;microbiome;microbiota;Monoclonal Antibodies;mortality;mouse model;Mus;Nosocomial Infections;novel;novel strategies;nutritional supplementation;Oral;Oryctolagus cuniculus;Outcome Study;parenteral administration;Pathogenesis;Patients;Performance;Persons;pharmacologic;Phase II Clinical Trials;Pilot Projects;Placebo Control;Population;prevent;primary outcome;Production;Productivity;Public Health;Publishing;Randomized;Rattus;Reaction;Recovery;Recurrence;Recurrent disease;Relapse;Research Personnel;Research Proposals;rho;Safety;secondary outcome;standard care;standard of care;Supplementation;systemic inflammatory response;Testing;Time;Tissues;Toxin;Treatment outcome;Vancomycin;Virulence Factors;Work

PROJECT_TITLE: Alanyl-glutamine supplementation of standard treatment for C. difficile infection

STUDY_SECTION: CRFS

STUDY_SECTION_NAME: Clinical Research and Field Studies of Infectious Diseases Study Section[CRFS]