NIH_SPENDING_CATS: Atherosclerosis;Behavioral and Social Science;Brain Disorders;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Depression;Heart Disease;Heart Disease - Coronary Heart Disease;Mental Health;Prevention;Tobacco;Tobacco Smoke and Health

ORG_CITY: PROVIDENCE

ORG_NAME: MIRIAM HOSPITAL

ORG_STATE: RI

PHR: PROJECT NARRATIVE Acute coronary syndrome (ACS) is a pressing public health concern and post-ACS depression interferes with health behavior engagement and cardiovascular risk reduction. The proposed R34 research will evaluate the feasibility and acceptability of study procedures of the Behavioral Activation for Health and Depression (BA- HD) intervention compared to Enhanced Usual Care (EUC) among 60 adults post-ACS with depression recruited from three distinct regions (Northeast, Midwest, and Southeast). The proposed research will standardize multisite procedures and gather necessary and sufficient information to inform a subsequent fully powered efficacy trial.

PI_NAMEs: BUSCH, ANDREW M;GATHRIGHT, EMILY CLAIRE (contact)

PROGRAM_OFFICER_NAME: CAMPO, REBECCA A

PROJECT_TERMS: acceptability and feasibility;acute coronary syndrome;Adherence;Adult;Affect;American Heart Association;arm;Behavior Therapy;Behavioral;Behavioral trial;cardiovascular health;cardiovascular risk factor;Clinical;clinically significant;comparison intervention;cost;Counseling;Data;Depressed mood;design;Development;Diet;diet and exercise;Disease;efficacy evaluation;efficacy trial;Feasibility Studies;feasibility trial;Feedback;follow-up;Goals;Health;health assessment;Health behavior;Health behavior change;Health system;Hospitalization;Hospitals;improved;Individual;Intervention;Interview;Life;Link;Maintenance;Manuals;Measurement;Medical;medically underserved;medication compliance;Mental Depression;Mental Health Services;Midwestern United States;model development;Moods;Morbidity - disease rate;mortality;mortality risk;Myocardial Infarction;National Heart, Lung, and Blood Institute;novel;novel strategies;Outcome;participant retention;Patients;Pharmaceutical Preparations;Physical activity;pilot test;Population;Positive Reinforcements;Preparation;prevent;Procedures;prognostic;programs;prospective;Protocols documentation;Provider;Public Health;Randomized;Recommendation;Recovery;recruit;Recurrence;Relapse;Research;Research Design;Risk;Risk Factors;Risk Reduction;rural underserved;safety net;Sampling;secondary outcome;Site;Smoke;Smoking;smoking abstinence;smoking cessation;Source;Standardization;Telephone;Testing;therapy development;Training;treatment as usual;Unhealthy Diet;United States;Unstable angina;usual care arm;Work

PROJECT_TITLE: Multisite feasibility of BA-HD: An integrated depression and behavioral risk factor reduction coaching program following acute coronary syndrome


ADMINISTERING_IC: GM

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Aging;Genetics

ORG_CITY: BALTIMORE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE COUNTY

ORG_STATE: MD

PHR: PROJECT NARRATIVE As cells age, the loss of proteostasis leads to the accumulation of excess, damaged, and aggregated proteins which interfere with essential cellular functions and promote the onset of age-related diseases, particularly in neurons and muscle. This proposal will define the biochemical and physiological functions of an orphan lysine methyltransferase which is required for proteostasis, likely its via methyltransferase activity on molecular chaperones and other factors within the proteostasis network. These studies will broaden our understanding of the cellular mechanisms used to prevent deterioration of proteome integrity during aging and aging- associated pathologies.

PI_NAMEs: GREEN, ERIN  (contact)

PROGRAM_OFFICER_NAME: BARSKI, OLEG

PROJECT_TERMS: Address;Age of Onset;age-related disease;Aging;aging related;aging related disease;Biochemical;biological adaptation to stress;Biological Assay;Biological Models;Biological Process;Blood Vessels;cell age;Cell Aging;Cell Physiology;Cells;Chemicals;Code;Data;Degradation Pathway;Deterioration;Enzymes;Etiology;experience;experimental study;Family;functional outcomes;Genetic;genetic approach;Genetic Models;Goals;Heart Diseases;Histones;Human;In Vitro;in vitro activity;insight;Investigation;Knowledge;Link;Lysine;Methylation;Methyltransferase;Modeling;Modification;Molecular;Molecular Chaperones;Muscle;Muscle Development;Muscular Atrophy;Myocardium;Nerve Degeneration;Neurons;non-histone protein;novel;Orphan;Outcome;overexpression;Pathology;Pathway interactions;Physiological;Post-Translational Protein Processing;prevent;protein aggregation;Protein Biosynthesis;protein function;protein protein interaction;protein TDP-43;Proteins;Proteome;Proteomics;proteostasis;proteostasis loss;Publishing;Quality Control;Regulation;Role;Saccharomycetales;senescence;Series;Skeletal Muscle;Stress;Structure;Substrate Specificity;targeted treatment;Testing;tool;Translations;Work;Yeasts

PROJECT_TITLE: Function of SMYD lysine methyltransferases in stress responses and proteostasis

STUDY_SECTION_NAME: Cell Structure and Function 1 Study Section[CSF1]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Pediatric;Physical Injury - Accidents and Adverse Effects;Post-Traumatic Stress Disorder (PTSD);Social Determinants of Health;Violence Research;Youth Violence

ORG_CITY: SAINT LOUIS

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE advance our understanding on how to alleviate the intergenerational impact of war trauma among second generation refugee children (SGRC) who have not directly experienced war trauma. This type I hybrid effectiveness-implementation trial tests a family strengthening (FS) model delivered through multiple family groups (MFG) combined with a virtual peer mentoring program called TeenAge Health Consultants (Virtual TAHC) aimed at addressing emotional and behavioral problems among youth born in the U.S. to parents resettled as refugees. The study will provide preliminary data on the potential impact of the intervention on the intergenerational mental health of youth from conflict-affected families resettled in the U.S.

PI_NAMEs: TUTLAM, NHIAL TIMOTHY (contact)

PROGRAM_OFFICER_NAME: SIMS, BELINDA ENITA

PROJECT_TERMS: 2 arm randomized control trial;acceptability and feasibility;Acculturation;Address;Affect;Age;Aggressive behavior;antisocial behavior;Anxiety;Area;arm;Behavioral;Biological;Cambodian;Child;Collection;Communities;community intervention;Complex;Conflict (Psychology);Country;Data;Development;Diagnostic;Discrimination;effectiveness testing;effectiveness/implementation trial;efficacy testing;Emotional;Emotional disorder;evidence base;experience;Exploration, Preparation, Implementation, and Sustainment;Family;gang;Generations;Goals;Grant;group intervention;healing;Health;High Prevalence;Holocaust survivor;Homicide;implementation determinants;implementation science;implementation strategy;Imprisonment;improved;Income;Interdisciplinary Study;intergenerational;Intervention;Knowledge;life span;Literature;Mental association;Mental Depression;Mental disorders;Mental Health;Mental Health Associations;Mentors;Methods;Modeling;Outcome;Parents;Participant;peer;peer coaching;Peer Group;Population;post intervention;Post-Traumatic Stress Disorders;Poverty;Problem behavior;programs;Public Health;racism;Randomized, Controlled Trials;recruit;Refugees;Research;resilience;Risk;School Drop-Outs;skills;social;Student Dropouts;substance use;Suicide;Symptoms;System;Systems Theory;Teenagers;Testing;theories;therapy design;Torture;Training;Trauma;trauma exposure;usual care arm;Veterans;Violence;virtual;virtual environment;virtual group;vulnerable community;War;Youth;youth violence

PROJECT_TITLE: Resettled Refugee Families for Healing (RRF4H): A Study of the Intergenerational Impact of War Trauma and Resilience

STUDY_SECTION: SERV

STUDY_SECTION_NAME: Mental Health Services Study Section[SERV]


ED_INST_TYPE: SCHOOLS OF MEDICINE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_DEPT: PSYCHIATRY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: PROJECT NARRATIVE Maternal stress during pregnancy is a major determinant of child neurodevelopment and long-term psychiatric risk. The current study will examine how understudied but crucially important features of maternal stress (timing, unpredictability) shape development of the autonomic nervous system and neurocircuitry in offspring prior to birth. This work holds potential to identify novel mechanisms underlying the intergenerational transmission of psychiatric risk and may, for the first time, define periods of gestation when fetal biology is most susceptible to variation in maternal experience

PI_NAMEs: HENDRIX, CASSANDRA LEI (contact)

PROGRAM_OFFICER_NAME: BECHTHOLT, ANITA JEAN

PROJECT_TERMS: Affect;Autonomic nervous system;Award;biobehavior;Biogenesis;biological adaptation to stress;Biological Markers;Biology;Birth;Blood flow;Brain;Buffers;career;career development;Child;Cognition;cohort;Conceptions;Coupled;Data;depressive symptoms;Development;Development Plans;Diagnostic;Discrimination;Ecological momentary assessment;Electrocardiogram;experience;Exposure to;Faculty;Family;fetal;Fetal autonomic nervous system;fetal blood;Fetal Development;Fetal Heart Rate;fetal programming;Functional Magnetic Resonance Imaging;Future;Goals;health disparity;heart rate variability;high risk;Hydrocortisone;hypothalamic-pituitary-adrenal axis;Image;immune activation;in utero;indexing;individual variation;infancy;Infant;Informal Social Control;insight;interest;intergenerational;Intervention;Knowledge;knowledge base;Life;life span;Link;longitudinal design;maternal stress;Measures;Mental Depression;Mental disorders;Minority;Modeling;multimodality;Nervous System;nervous system development;Nervous System Physiology;neural;neural circuit;neurodevelopment;Neurosciences;Newborn Infant;novel;offspring;Parents;Perinatal;perinatal mental health;Placenta;Play;Positioning Attribute;postnatal period;Predisposition;Pregnancy;prenatal;prenatal stress;Process;programs;psychologic;psychosocial;Recording of previous events;recruit;Research;Research Project Grants;resilience;Resources;Rest;Risk;Risk Factors;Role;Shapes;statistics;Stress;symptomatology;System;Techniques;Temperament;Third Pregnancy Trimester;Time;Training;translational research program;translational study;transmission process;Trauma;Variant;Work

PROJECT_TITLE: Psychosocial unpredictability during pregnancy and offspring neurodevelopment: Uncovering mechanisms and sensitive windows in utero


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Hearing Loss;Neurosciences;Prevention;Primary Health Care;Rural Health;Social Determinants of Health

ORG_CITY: LEXINGTON

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: PROJECT NARRATIVE Hearing loss affects over 40 million adults in the United States and can negatively impact many areas of life for adults. The lack of access to diagnostic hearing tests prevents timely diagnosis and treatment of hearing loss, especially, among adults who live in rural areas. This study will (1) evaluate the experiences and challenges in obtaining hearing tests among adults who live in rural areas and are patients at rural health clinics, and (2) develop a program, in partnership with rural patients and medical providers, which can help rural adults get easier access to hearing tests.

PI_NAMEs: BUSH, MATTHEW LEE (contact)

PROGRAM_OFFICER_NAME: KING, KELLY ANNE

PROJECT_TERMS: Address;Administrator;Adult;Advisory Committees;Affect;Appalachian Region;Area;barrier to care;care delivery;Certification;Chronic;Communication impairment;Communities;community advisory board;Community Health;Community Healthcare;Country;County;Depressed mood;Development;Diagnosis;Diagnostic;Disease;Education;Employment;Enabling Factors;Enrollment;Environmental Risk Factor;Epidemiology;Evaluation;experience;Face;Geographic state;Goals;Health;health assessment;health care availability;health care delivery;health care service;health care service utilization;Health Personnel;Health Resources;Health Services Accessibility;Healthcare;Healthcare promotion;Healthcare Systems;Hearing;hearing impairment;hearing loss treatment;Hearing Tests;improved;innovation;Intervention;Kentucky;Life;Measurable;Medical;Medical Economics;medical specialties;medically underserved;Methods;Morbidity - disease rate;mortality;novel;Occupational;older adult;Outcome;patient navigation;Patients;Phase;pilot test;Population;Positioning Attribute;practice-based research network;Precede-Proceed Model;Predisposing Factor;preference;Prevalence;prevent;Prevention;Primary Care;primary care practice;primary care services;programs;Protocols documentation;Provider;Public Health;Reinforcing Factor;Research;Resources;Rural;Rural Appalachia;rural area;Rural Community;rural health clinic;rural healthcare;rural patients;rural underserved;screening;social;therapy development;treatment comparison;underserved community;United States;urban setting;virtual;Vulnerable Populations;Well in self;young adult

PROJECT_TITLE: Hearing Healthcare Assessment in Rural Communities (HHARC)


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Asthma;Climate-Related Exposures and Conditions;Clinical Research;Health Effects of Household Energy Combustion;Health Effects of Indoor Air Pollution;Lung;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Despite the known dangers of air pollution to children with asthma, little is known about the contribution of radon exposure to asthma morbidity. With recent data reporting indoor exposure to radon associated with COPD morbidity and mortality, the goals of this research project are to understand the effect of exposure to radon progeny found within classrooms on health outcomes of inner-city students with asthma and to identify biomarkers associated with particle radioactivity exposure. The findings of the proposed research will provide important information that may shape public policy to improve the health of inner-city children with asthma and may be used to design public health intervention trials.

PI_NAMEs: BANZON, TINA  (contact)

PROGRAM_OFFICER_NAME: QUINN, ASHLINN KO

PROJECT_TERMS: Absenteeism;Affect;air cleaner;Air Pollutants;Air Pollution;airway inflammation;Allergens;Allergic Disease;Asthma;asthma exacerbation;Award;Biological;Biological Markers;biomarker identification;carcinogenicity;career;career development;catalyst;cell injury;Child;Child Health;Childhood;Childhood Asthma;Chronic Disease;Chronic Obstructive Pulmonary Disease;clinical investigation;Clinical Investigator;Clinical Trials;cohort;Collaborations;Data;Data Reporting;design;Development;Diagnosis;disability;Educational Activities;elementary school;Enrollment;Environment;Environmental Epidemiology;Environmental Exposure;Environmental Risk Factor;Epidemiology;Evaluation;Exhalation;Exposure to;FGF2 gene;fine particles;Funding;Gases;Goals;Health;health care service utilization;high efficiency particulate air filter;Hospitalization;IL8 gene;improved;Indoor Air Pollution;indoor allergen;indoor exposure;indoor pollutant;Inflammation;Inflammatory;Infrastructure;Inhalation;inner city;Institution;Interleukin-6;Intervention;Intervention Studies;Intervention Trial;Learning;Link;Longitudinal Studies;Lung;Malignant neoplasm of lung;Measures;Mentors;Modeling;modifiable risk;Morbidity - disease rate;mortality;Nitric Oxide;novel;Obstructive Lung Diseases;Outcome;Outcomes Research;Oxidative Stress;parent grant;Participant;particle;particle exposure;Particulate Matter;Patients;Peer Review;Persons;Phenotype;Physical assessment;Physical environment;Planet Earth;Policies;pollutant;Population;predictive modeling;programs;Protocols documentation;public health intervention;Public Health Schools;Public Policy;Publications;pulmonary function;Radiation;Radioactive;Radioactivity;Radioisotopes;Radon;Regulation;remediation;Research;Research Personnel;Research Project Grants;Resources;Respiratory System;response;Risk;Risk Factors;Role;Sampling;School-Age Population;Schools;Serum;Shapes;skills;spatiotemporal;Students;Symptoms;Testing;Time;Training;United States;United States National Institutes of Health;Universities;Uranium

PROJECT_TITLE: Evaluation of radon progeny and air pollution effects in asthma


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Aging;Atherosclerosis;Cardiovascular;Clinical Research;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Human Genome;Prevention

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Despite effective cholesterol-lowering therapies, cardiovascular disease (CVD) risk remains a major unmet clinical need. We hypothesize that genes expressed in the artery smooth muscle cells play a prominent causal role in atherosclerotic plaque instability and CVD risk independent of genes affecting blood cholesterol level. To address this, we propose a unique integrative approach, validated by natural “human knockouts,” to fine-map the genome regions for CVD, discover causal genes, and elucidate safe therapeutic targets for smooth muscle cell casual pathways in atherosclerosis stability and CVD risk independent of blood cholesterol.

PI_NAMEs: REILLY, MUREDACH P (contact);SALEHEEN, DANISH

PROGRAM_OFFICER_NAME: SCHOPFER, DAVID WESLEY

PROJECT_TERMS: Acceleration;Address;Affect;Alleles;Arterial Fatty Streak;Arteries;Atherosclerosis;biobank;Biological;Biological Assay;Blood;Blood Vessels;Callback;Cardiovascular Diseases;cardiovascular disorder risk;Carotid Arteries;Carotid Artery Plaques;causal variant;Cell Aging;Cell Lineage;Cell Proliferation;cell type;Cells;Cholesterol;Clinical;cohort;conditional knockout;Coronary Arteriosclerosis;coronary artery calcium;Data;Disease;Disease regression;Etiology;exome;Family;fine art;Gene Deletion;Gene Expression;gene function;Genes;Genetic;genetic analysis;genetic pedigree;Genetic Variation;Genome Mappings;genome resource;genome sequencing;genome wide association study;Heterozygote;Histology;Human;Human Genetics;human model;Human Resources;improved;in situ sequencing;intimal medial thickening;Knock-out;knockout gene;Lesion;Ligation;Lipids;Lipoproteins;Location;loss of function;Low-Density Lipoproteins;Maps;Meta-Analysis;mouse model;multi-ethnic;Mus;Mutation;Pakistan;Participant;Pathway interactions;Phenotype;Plasma;Play;pleiotropism;Population Genetics;programs;rare variant;recombinase;Residual state;Resolution;Resources;RNA;Role;Safety;safety assessment;senescence;Signal Transduction;Smooth Muscle Myocytes;Stable Disease;System;Testing;therapeutic target;Time;trait;transcriptome sequencing;transcriptomic profiling;transcriptomics;Tretinoin;Variant;Vascular remodeling;Vascular Smooth Muscle;whole genome;Work

PROJECT_TITLE: Identification of smooth muscle cell genes causal in atherosclerotic plaque stability and cardiovascular disease risk

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


ADMINISTERING_IC: NS

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Autoimmune Disease;Brain Disorders;Chronic Pain;Multiple Sclerosis;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy

ORG_CITY: PITTSBURGH

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project Narrative Neuropathic pain in multiple sclerosis (MS) afflicts over 50% of patients; however, currently available analgesic drugs are inadequate, due in part to a lack of understanding about the underlying mechanisms that drive multiple sclerosis-associated neuropathic pain (MSNP). This proposal aims to use cellular manipulations and pharmacologic interventions to elucidate microglial mechanisms that will guide future development of non-opioid therapeutics to treat MSNP. We focus on the FDA-approved S1PR1 agonist, fingolimod, not only for its disease modifying properties, but also as a treatment for the pain of MS.

PI_NAMEs: LAMERAND, SYDNEY  (contact)

PROGRAM_OFFICER_NAME: MATTHEWS, MARGUERITE

PROJECT_TERMS: Affect;Agonist;allodynia;Analgesics;antagonist;Attenuated;Behavior;Behavioral;behavioral pharmacology;Binding;Biological Assay;Central Nervous System;chronic pain;CNS autoimmune disease;Cognitive deficits;comorbidity;comparison control;Coupling;cytokine;Data Analyses;Demyelinations;design;Development;Disease;Experimental Autoimmune Encephalomyelitis;Experimental Designs;experimental study;FDA approved;Functional disorder;Future;G-Protein-Coupled Receptors;Genes;Genetic;glial activation;Goals;GTP-Binding Proteins;Hyperalgesia;In Situ;In Vitro;Inflammation;Inflammatory;Intervention;intraperitoneal;Intrathecal Injections;Knock-out;Knowledge;Laboratories;Learning;Macrophage-1 Antigen;Mediating;Methods;Microglia;Modeling;Motor;motor symptom;mouse model;Multiple Sclerosis;multiple sclerosis treatment;Mus;Neuroimmune system;non-opioid analgesic;Oranges;pain behavior;Pain management;pain relief;painful neuropathy;Pathway interactions;Patients;Peripheral;Persons;Pharmaceutical Preparations;pharmacologic;prevent;Primary Cell Cultures;Property;Proteins;Publications;Reporting;Research Personnel;Rodent Model;Sensory;Signal Transduction;Site;Sphingosine-1-Phosphate Receptor;Spinal;Spinal Cord;Testing;Training;Up-Regulation

PROJECT_TITLE: Microglia and S1PR1 Signaling in Multiple Sclerosis Associated Neuropathic Pain


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Brain Disorders;Clinical Research;Health Services;Intellectual and Developmental Disabilities (IDD);Machine Learning and Artificial Intelligence;Mental Health;Pediatric;Prevention;Women's Health Research

ORG_CITY: MINNEAPOLIS

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE This K23 proposal entitled, Towards Equitable Early Identification of Autism Spectrum Disorder in Females, will test the hypothesis that using computational approaches to identify sex-related measurement bias and characterize heterogeneity in early ASD symptoms will identify ASD risk profiles that can be clinically actionable in practice. Training goals focused on conducting community-based screening for ASD, computational modeling of heterogeneity, and dissemination and implementation science, under the mentorship of Dr. Damien Fair, Dr. Jed Elison and Dr. Timothy Beebe will support the career development of Dr. Catherine Burrows, an Assistant Professor at the University of Minnesota. The work herein promises to elucidate novel, clinically actionable screening practices to lower the age of identification of ASD-related concerns.

PI_NAMEs: BURROWS, CATHERINE ANN (contact)

PROGRAM_OFFICER_NAME: KAU, ALICE S

PROJECT_TERMS: Age;Algorithms;Assessment tool;autism spectrum disorder;autism symptoms;autistic children;Brain;career development;Child;Clinical;clinical translation;clinically actionable;clinically relevant;cohort;Cohort Studies;Communities;community research;Computer Models;Data;Data Collection;Decision Trees;Detection;Development;Diagnosis;Diagnostic;Dimensions;disorder risk;dissemination science;early childhood;Early identification;Early Intervention;early screening;Environment;Equity;Evaluation;Factor Analysis;Family;Female;Funding;Future;gender equity;General Population;Goals;gradient boosting;Heterogeneity;implementation science;improved;information gathering;Infrastructure;Intervention;Interview;Knowledge;lens;Life;life span;Machine Learning;male;Measurement;Measures;Medical;Mental disorders;Mentored Clinical Scientist Development Program;Mentors;Mentorship;Methodology;Methods;Minnesota;Modeling;Modified Checklist for Autism in Toddlers;National Institute of Mental Health;novel;Outcome;Parents;pediatric department;pediatrician;Perception;Performance;Phase;Positioning Attribute;precision medicine;Primary Care;professor;Provider;Psychologist;Quality of life;Questionnaires;random forest;recruit;Registries;repetitive behavior;Reporting;Research;Risk;Sampling;screening;Screening procedure;service intervention;sex;Sex Differences;Signs and Symptoms;Site;skills;social communication;Strategic Planning;Subgroup;Symptoms;Testing;Toddler;Training;training opportunity;Training Support;trait;translational research program;Universities;Visit;Waiting Lists;Work

PROJECT_TITLE: Towards equitable early identification of autism spectrum disorders in females

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Biobehavioral and Behavioral Sciences Study Section[CHHD-H]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Disability Research;Mental Health;Mental Illness;Neurosciences;Pediatric;Prevention;Psychosis;Schizophrenia;Serious Mental Illness

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative The proposed research will develop and test an intervention, Resilience Training for Teens, which aims to reduce transdiagnostic symptoms and improve social cognition and social functioning in adolescents who are at an elevated risk for a serious mental illness. Thus, this project could provide the basis for a novel, mechanism-based approach to improving outcomes and reducing severe disability in transdiagnostically at-risk adolescents. This project, through a set of four training goals, coursework, and a strong mentorship team, will provide this candidate with the additional training needed to become an independent intervention researcher.

PI_NAMEs: DETORE, NICOLE R. (contact)

PROJECT_TERMS: 19 year old;acceptability and feasibility;Address;Adolescence;Adolescent;adolescent mental health;Anxiety;Anxiety Disorders;arm;Attention;Awareness;Biological;Biometry;Chronic Disease;Clinical;Cognitive;cognitive function;Complex;Conscious;Data;Depressed mood;Development;Diagnostic;disability;Disability prevention;Disease;Distress;early experience;Early Intervention;Empathy;Enrollment;Exercise;experience;feasibility testing;Feedback;Foundations;functional decline;functional improvement;functional outcomes;Goals;help-seeking behavior;high school;Hour;Impairment;improved;improved outcome;Individual;Intervention;Knowledge;life span;Link;Manuals;Measures;Mediating;Mental Depression;Mental disorders;Mental Health;Mental Health Services;mental representation;mental state;mentalization;Mentors;Mentorship;mindfulness;Mood Disorders;multidisciplinary;Neurocognitive;neurodevelopment;Neuronal Plasticity;Neuropsychology;novel;Onset of illness;Participant;Performance;Persons;Population;post intervention;Predictive Factor;prevent;Prevention approach;preventive intervention;Process;programs;promote resilience;protective factors;psychiatric symptom;Psychopathology;Psychoses;psychotic;Psychotic Disorders;psychotic symptoms;Publishing;Randomized;Randomized, Controlled Trials;recruit;reduce symptoms;Reporting;Research;Research Personnel;resilience;Risk;Risk Factors;screening;self-compassion;severe mental illness;Severities;skills;social;social cognition;Social Functioning;Social Interaction;Social Perception;social relationships;Social support;Standardization;subclinical depression;success;suicidal;Symptoms;Teenagers;Testing;theory of mind;therapy design;Time;Training;Waiting Lists;young adult;Youth

PROJECT_TITLE: Development of a transdiagnostic intervention for adolescents at risk for serious mental illness

STUDY_SECTION: EMHI

STUDY_SECTION_NAME: Effectiveness of Mental Health Interventions Study Section[EMHI]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Dental, Oral, and Craniofacial Disease;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Rare Diseases

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: RELEVANCE TO PUBLIC HEALTH Combined reflectance confocal microscopy - optical coherence tomography (RCM-OCT) imaging may noninvasively guide diagnosis of oral potentially malignant lesions and cancers, with reduced need for biopsy. The imaging in real-time at the bedside may guide diagnosis and treatment in a single patient visit – a “one stop shop” patient care paradigm. The imaging may provide care to deserving patients at low affordable costs in 15-20 low-and-middle income countries, in which high incidence rates and prevalence of oral cancer is a major healthcare problem.

PI_NAMEs: CHATURVEDI, PANKAJ ;FOX, WILLIAM J.;IFTIMIA, NICUSOR ;RAJADHYAKSHA, MILIND  (contact)

PROGRAM_OFFICER_NAME: BEIER, HOPE THOMAS

PROJECT_TERMS: Adoption;Adult;Africa;Africa South of the Sahara;Algorithms;Architecture;Asia;Atypia;Benign;Biopsy;Caliber;cancer care;Cancer Center;cancer diagnosis;Carcinoma;care costs;care delivery;Caring;cellular imaging;Cellular Morphology;Central Asia;Cessation of life;Clinic;Clinical;clinical examination;Code;Confocal Microscopy;Connective Tissue;cost;design;design,build,test;Detection;Developing Countries;Devices;Diagnosis;diagnosis standard;Diagnostic;Dysplasia;Engineering;Epithelial Attachment;Epithelium;Erythroplasia;Fibrosis;follow-up;Fright;Future;Guidelines;Head and neck structure;Head and Neck Surgery;Healthcare;Hospitals;Image;image guided;imaging approach;imaging capabilities;imaging detection;Imaging Device;Imaging Techniques;in vivo;Incidence;India;Industry;innovation;intraoral probe;Invaded;Investments;keratinization;Lamina Propria;laptop;Lesion;Leukoplakia;low and middle-income countries;Malignant - descriptor;malignant mouth neoplasm;Malignant Neoplasms;manufacture;Memorial Sloan-Kettering Cancer Center;meter;microscopic imaging;Monitor;New York;non-invasive imaging;novel;Operative Surgical Procedures;Optical Coherence Tomography;optical imaging;Oral;Oral cavity;Oral Diagnosis;oral dysplasia;oral lesion;Oral Medicine;outreach clinics;Pain;Pathology;Patient Care;Patient Compliance;Patients;physical science;Population;portability;Prevalence;prospective test;Protein Structure Initiative;Public Health;reflectance confocal microscopy;Reporting;research clinical testing;scale up;Severities;Skin Cancer;socioeconomics;Specificity;Stratification;success;Testing;Time;timeline;Triage;Underserved Population;Validation;Visit;Visual;World Health Organization

PROJECT_TITLE: Reflectance confocal microscopy-optical coherence tomography (RCM-OCT) imaging of oral lesions: Toward an affordable device and approach for developing countries

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ISB-J(57)R]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Adolescent Sexual Activity;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Contraception/Reproduction;Infectious Diseases;Pediatric;Prevention;Sexually Transmitted Infections;Teenage Pregnancy

ORG_CITY: WELLESLEY

ORG_NAME: WELLESLEY COLLEGE

PHR: Fathers’ talk with teens about sex can protect teens from risky sexual behavior, but few interventions support fathers’ preparation for and engagement with health-promoting talk with teens about sex and relationships. The proposed project will develop a 3-module prototype for a father-teen online program to support health-promoting father-teen communication about sex and relationships, and to evaluate the program’s acceptability, feasibility, and preliminary efficacy. This research contributes to public health by developing an intervention which addresses fathers as an under-utilized resource to support teens’ sexual health, using novel approaches to maximize father-teen communication about sex.

PI_NAMEs: GROSSMAN, JENNIFER  (contact)

PROGRAM_OFFICER_NAME: POPKIN, RONNA

PROJECT_TERMS: acceptability and feasibility;Address;Adolescent;aged;Attention;behavior change;Black race;Communication;Communities;community organizations;condoms;Consent;Contraceptive Usage;cost;Data;Daughter;design;Development;dosage;efficacy evaluation;Elements;Enrollment;ethnic diversity;Ethnic Origin;expectation;Family;Fathers;Feedback;Financial cost;Frequencies;Future;Gender;Goals;Health;health equity;Health Promotion;high risk sexual behavior;high school;Hispanic;innovation;Intervention;intervention mapping;Interview;Knowledge;Measures;Methods;Multiple Partners;National Institute of Child Health and Human Development;Needs Assessment;Not Hispanic or Latino;novel strategies;online intervention;Outcome;outreach;parenting intervention;Parents;Participant;participant enrollment;Patient Recruitments;peer;peer support;Persons;Pilot Projects;post intervention;Pregnancy in Adolescence;Preparation;Process;Program Acceptability;programs;Protocols documentation;prototype;Public Health;Questionnaires;racial diversity;Randomized, Controlled Trials;recruit;Reporting;Reproductive Health;reproductive health of adolescents;Research;Resources;Risk;Sampling;School-Age Population;Self Efficacy;sex;Sex Behavior;Sexual Health;sexual risk behavior;Sexual Transmission;Sexually Transmitted Diseases;skills;social;social cognitive theory;social culture;Son;Support Groups;Surveys;Technology;teenage mother;Teenagers;Testing;theories;therapy design;Translating;transmission process;unintended pregnancy;United States National Institutes of Health;Youth

PROJECT_TITLE: Feasibility and acceptability of a father-based intervention to support adolescents reproductive health

STUDY_SECTION: HPC

STUDY_SECTION_NAME: Health Promotion in Communities Study Section[HPC]


NIH_SPENDING_CATS: Behavioral and Social Science;Chronic Pain;Clinical Research;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hematology;Mental Health;Pain Research;Pediatric;Rare Diseases;Sickle Cell Disease;Social Determinants of Health

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Sickle cell disease is a painful inherited disorder that affects approximately 100,000 people in the United States, and more than half of these individuals develop chronic or persistent pain that is often severe and disabling. The factors that predict whether an individual with sickle cell disease will develop severe, disabling pain are unclear. The goal of this project is to identify the factors that predict severe pain outcomes in these patients in order to improve pain management strategies and guide future studies of non-opioid therapies for treatment of their pain.

PI_NAMEs: KENNEY, MARTHA OBENG (contact)

PROGRAM_OFFICER_NAME: LOUDEN, ANDREW

PROJECT_TERMS: Acute;Address;Adolescence;Adolescent and Young Adult;Adult;Advisory Committees;Affect;Age;Anesthesiology;Biological;biopsychosocial;body map;career;career development;Characteristics;Child;Childhood;Chronic;chronic pain;clinical decision-making;clinical prognostic;Clinical Trials;cohort;Cohort Studies;Complex;coping;Cross-Sectional Studies;Data;Development;Development Plans;disability;Disabling;Disease Management;Doctor of Philosophy;effective intervention;emerging adult;Enrollment;Etiology;Face;Female;Funding;Future;Genotype;Globin;Goals;Health Care Costs;health care service utilization;Hereditary Disease;improved;Individual;innovation;interest;Intervention;Lead;Linear Regressions;Link;longitudinal design;Longitudinal Studies;longitudinal, prospective study;Low income;Measures;Mentors;Modeling;mortality;Nature;non-opioid analgesic;Opioid;Outcome;Outcome Assessment;Pain;pain catastrophizing;Pain management;pain model;pain outcome;pain relief;pain sensitivity;pain-related disability;Pathogenesis;Patient Outcomes Assessments;Patient Selection;Patient-Focused Outcomes;Patients;Pediatrics;Persistent pain;Persons;Physical Function;physically handicapped;Polynomial Models;Positioning Attribute;Predictive Factor;predictive modeling;Preventive;primary outcome;Procedures;Prognosis;prognostic;prognostic model;prognostic tool;Property;prospective;psychologic;psychological distress;Psychological Factors;Psychometrics;psychosocial;Quality of life;Questionnaires;Recurrent pain;Registries;Research;Research Design;Risk;risk prediction model;Sampling;Secondary pain;Self Efficacy;Sensory;Severities;sex;Sickle Cell Anemia;sociodemographic predictors;Statistical Data Interpretation;Statistical Methods;Statistical Models;Testing;Therapeutic;Time;Training;United States;Universities;vaso-occlusive crisis;Virginia;Work

PROJECT_TITLE: Predictors of Pain Severity and Pain-Related Outcomes in Individuals with Sickle Cell Disease


NIH_SPENDING_CATS: Bioengineering;Genetics;Human Genome

ORG_CITY: Columbus

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative The nuclear package of eukaryotic DNA is regulated to express only essential genes for specific cell functions and proliferation. The proposed research will investigate how active genes are positioned in the hierarchical genome organization, the movement speeds and directions of different chromosomal regions, and whether we can predict and identify compartments by chromatin mobility and transcription rate in the nucleus. Live-cell imaging combined with biophysical models and high-throughput RNA analysis will be used to dissect the dynamic organization of individual chromosomes and map the active gene positions, which leads to a deeper understanding of the nuclear function and genome stability in single cells under physiological conditions.

PI_NAMEs: TU, LI-CHUN  (contact)

PROGRAM_OFFICER_NAME: YEH, ALVIN TIEN-WEI

PROJECT_TERMS: 3-Dimensional;Architecture;biophysical model;Cell Nucleus;Cell Physiology;Cell Proliferation;cell type;Cells;Chromatin;Chromosome Territory;Chromosomes;Clustered Regularly Interspaced Short Palindromic Repeats;Color;Data;DNA;Enhancers;Essential Genes;Foundations;Gene Expression;Gene Order;Genes;genetic information;Genetic Transcription;Genome;Genome Stability;genomic locus;Human Genome;imaging approach;Imaging Techniques;improved;Individual;Interphase Chromosome;live cell imaging;Maps;Mediating;Microtubule Polymerization;Molecular Conformation;Morphology;Mouse Embryonic Stem Cells;Movement;non-invasive imaging;Nuclear;Permeability;Physiological;promoter;Proteins;Research;Resolution;RNA;RNA analysis;Speed;Technology;Temperature;Time;transcriptome sequencing

PROJECT_TITLE: Gene positioning and dynamic chromatin organization of the human genome

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MGG-C(55)R]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Biotechnology;Chronic Pain;Drug Abuse (NIDA only);Neurodegenerative;Neurosciences;Opioids;Pain Research;Peripheral Neuropathy;Substance Misuse

ORG_CITY: RESEARCH TRIANGLE PARK

ORG_NAME: RESEARCH TRIANGLE INSTITUTE

PHR: Narrative Chronic pain is a significant public health issue that afflicts millions of people worldwide. Accumulating evidence suggests that activation of Neuropeptide B/W Receptor 1 produced analgesic effects. This application proposes to perform a high throughput screen of a diverse small molecule library to identify small molecule Neuropeptide B/W Receptor 1 agonists as potential therapy for chronic pain treatment.

PI_NAMEs: DECKER, ANN M;NGUYEN, THUY  (contact)

PROGRAM_OFFICER_NAME: ANANTHAN, SUBRAMANIAM

PROJECT_TERMS: addiction;Adverse effects;Affect;Agonist;Analgesics;Biological Assay;Biological Availability;blood-brain barrier permeabilization;Brain region;Carrageenan;Cell Line;Cells;Chemicals;chronic constriction injury;chronic pain;chronic pain management;Clinic;conditioned place preference;Constipation;counterscreen;Cyclic AMP;Dependence;Diabetes Mellitus;Dimethyl Sulfoxide;Dose;drug candidate;drug discovery;Dryness;effective therapy;Ensure;Evaluation;Formalin;Formalin Tests;G-Protein-Coupled Receptors;Genes;Health;high throughput screening;Hyperalgesia;Immune;In Vitro;Inflammatory;inflammatory pain;Injections;Knockout Mice;Laboratories;lead optimization;Libraries;Ligands;Ligation;locus ceruleus structure;mechanical allodynia;Mediating;Metabolic;midbrain central gray substance;Modeling;Morphine;Naloxone;National Institute of Mental Health;Nerve;Neuropathy;neuropeptide B;Neuropeptides;Nociception;non-opioid analgesic;novel;NPBWR1 gene;Obesity;Opioid;Opioid agonist;Opioid Receptor;Pain;Pain management;pain model;painful neuropathy;Pathologic;Patients;Peptides;peptidomimetics;Persons;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacologic;Powder dose form;programs;Property;Psychotropic Drugs;Public Health;Regulation;release of sequestered calcium ion into cytoplasm;Reporting;Research;response;Role;Sampling;scaffold;sciatic nerve;screening program;Series;small molecule;small molecule libraries;Solubility;Spinal Cord;Structure;synergism;System;Testing;Therapeutic;therapeutic candidate;therapy development;tool;Validation;Vendor

PROJECT_TITLE: Identification of small molecule NPBWR1 agonists

STUDY_SECTION: DMPB

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology B Study Section[DMPB]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Infectious Diseases;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: PROJECT NARRATIVE Immunosuppressed individuals are at increased risk of persistent COVID-19 infection and therapeutic treatment failure, but the mechanisms by which chronic infection, viral evolution, and drug resistance occur in this population are poorly understood. The proposing investigators will leverage an existing translational research infrastructure with experience recruiting cohorts of immunosuppressed individuals with COVID-19 and broad expertise in clinical research, viral quantification, viral culture, sequencing and immunology. The primary goal of this proposal is to determine the host and virologic characteristics that promote chronic viral infection, and the results will provide critical new data about COVID-19 pathogenesis, variant evolution, therapeutic response, and inform the clinical care of immunosuppressed populations.

PI_NAMEs: BARCZAK, AMY K;LI, JONATHAN  (contact);SIEDNER, MARK J

PROGRAM_OFFICER_NAME: SASTALLA, INKA I

PROJECT_TERMS: 2019-nCoV;Acceleration;Address;Amino Acids;Anti-viral Agents;Antibody titer measurement;Antigens;antiviral drug development;Area;B cell therapy;CD8-Positive T-Lymphocytes;Characteristics;Chronic;chronic infection;clinical care;Clinical Research;clinical risk;cohort;Collaborations;COVID-19;COVID-19 mortality;COVID-19 pandemic;COVID-19 pathogenesis;COVID-19 therapeutics;Data;deep sequencing;Disease;Drug resistance;Enrollment;Epidemiology;Evolution;experience;General Population;Genes;Genetic;Goals;Health;Hematologic Neoplasms;Hematopoietic Stem Cell Transplantation;high risk population;Immune;Immune response;Immunocompetent;Immunocompromised Host;immunodeficiency;Immunologics;Immunology;immunosuppressed;Immunosuppression;improved;Incidence;Individual;Infection;Laboratories;Long COVID;Methods;Monoclonal Antibodies;Nature;novel vaccines;Outcome;Participant;Pathway interactions;Patients;Persons;Play;Population;Productivity;Public Health;Publications;recruit;Regimen;Research Infrastructure;Research Personnel;Resistance;response;Risk;Risk Factors;Risk Reduction;RNA;Role;Sampling;SARS-CoV-2 infection;SARS-CoV-2 spike protein;SARS-CoV-2 variant;Severity of illness;Source;Symptoms;T cell response;Therapeutic;transcriptome sequencing;Translational Research;transmission process;Treatment Failure;treatment response;Variant;Viral;Viral Drug Resistance;Viral Load result;viral RNA;virology;Virus;Virus Diseases

PROJECT_TITLE: Characterization of Persistent COVID-19

STUDY_SECTION: EDIT

STUDY_SECTION_NAME: Etiology, Diagnostic, Intervention and Treatment of Infectious Diseases Study Section[EDIT]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Complementary and Integrative Health;Dental, Oral, and Craniofacial Disease;Dissemination and Implementation Research;Drug Abuse (NIDA only);Prevention;Substance Misuse

PHR: We propose to continue our work—to lead, participate in, and support activities that will maximize the creativity, productivity, scientific rigor, and dissemination of SOBC products and approaches to meaningfully impact health behaviors. Our team created the first generation SOBC website and Measures Repository, and we have developed an innovative and impactful plan for expanding and improving upon those tools, to facilitate adoption of the experimental medicine approach and collaboration between basic and applied scientists. We also propose innovative scientific outreach and dissemination approaches, with deliverables that we will translate directly into tools for use by the broader scientific community.

PI_NAMEs: EDMONDSON, DONALD  (contact)

PROGRAM_OFFICER_NAME: RIDDLE, MELISSA

PROJECT_TERMS: Address;Adopted;Adoption;Area;Automation;Award;Basic Science;Behavior;behavior change;behavior measurement;Behavioral;Behavioral Mechanisms;behavioral outcome;Behavioral Sciences;Clinical;Clinical Sciences;Collaborations;Communication;Communities;Creativeness;Data;digital delivery;digital tool;Education;Educational workshop;Effectiveness;Ensure;evidence base;Future;Generations;Goals;Health behavior;Hour;Human;implementation science;improved;innovation;Institution;international scientific organization;Internet;Intervention;intervention effect;Intuition;Joints;Lead;Literature;Manuscripts;Measurement;Measures;Medicine;meetings;Meta-Analysis;Methods;Modeling;novel;novel strategies;open data;outreach;Phase;Play;podcast;Practice Guidelines;Process;Productivity;programs;Reach, Effectiveness, Adoption, Implementation, and Maintenance;repository;Reproducibility;Research;Research Personnel;Resources;Role;Science;science education;Scientist;Shapes;Standardization;Structure;symposium;systematic review;Taxonomy;Testing;therapy development;tool;Translating;United States National Institutes of Health;Universities;usability;Validation;Vision;Visual;web site;webinar;Work;working group

PROJECT_TITLE: Columbia University Science of Behavior Change Resource and Coordinating Center renewal


ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative Proposed studies will characterize the autophagy-dependent mechanism(s) that regulate a cell's ability to escape from replicative crisis and initiate a tumor. This research will increase our understanding about the molecular basis of autophagy and its implication in cell death, genome stability, and early stages of malignant transformation. In addition to these fundamental advances, this project has translational potential because it will provide new insights into the roles of autophagy in cancer biology and will enhance the efficacy of existing autophagy manipulation methods.

PI_NAMEs: NASSOUR, JOE  (contact)

PROGRAM_OFFICER_NAME: LUO, RUIBAI

PROJECT_TERMS: Autophagocytosis;Autophagosome;Award;Binding;Bioinformatics;biomarker identification;Bypass;Cancer Biology;cancer therapy;carcinogenesis;CDKN2A gene;Cell Aging;Cell Cycle Arrest;Cell Cycle Checkpoint;Cell Death;Cells;chromothripsis;Color;Computer Analysis;CRISPR screen;CRISPR/Cas technology;Cytoplasm;Data;Dedications;Defect;design;Development;DNA;Double Minutes;Educational process of instructing;epigenomics;Excision;expectation;Fluorescent in Situ Hybridization;Frequencies;Functional disorder;Genes;genome sequencing;Genome Stability;genome-wide;Genomics;Grant;Human;Immunoprecipitation;in vivo;Incidence;Individual;insight;Knock-out;Knockout Mice;Knowledge;Laboratories;live cell imaging;Malignant - descriptor;Malignant Neoplasms;Mass Spectrum Analysis;Measures;Membrane;Mentors;Mentorship;Methods;Molecular;Monitor;mouse model;Mouse Strains;Mus;Neoplastic Cell Transformation;next generation sequencing;novel;Oncogenic;Pathway interactions;Phase;Predisposition;Premalignant Cell;Prevention;Proliferating;Proteins;Proteomics;receptor;recruit;Research;Research Project Grants;response;restraint;Risk;Role;senescence;Signal Pathway;skills;Stimulator of Interferon Genes;success;Technology;telomere;Telomere Shortening;Testing;Therapeutic;Tissues;TP53 gene;Training;Training Activity;transcriptomics;Transgenic Mice;Transgenic Organisms;translational potential;tumor;Tumor Suppressor Proteins;tumorigenesis;whole genome;Work;Writing

PROJECT_TITLE: The role of autophagy in the escape from replicative crisis and tumorigenesis

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Transition to Independence Study Section (I)[NCI-I]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects;Racial and Ethnic Minority Health Research;Social Determinants of Health;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: WASHINGTON

ORG_DEPT: MISCELLANEOUS

ORG_NAME: GEORGE WASHINGTON UNIVERSITY

ORG_STATE: DC

PHR: NARRATIVE. The overarching goal of this study is to examine the impact of repetitive head impacts (RHI) and traumatic brain injury (TBI) from American football and the contribution of early-life social determinants of health (SDOH) to later-life cognitive function, neuropsychiatric symptoms, structural MRI features, and plasma biomarkers of neurodegenerative disease in 200 Black men. Our research will result in an unprecedented data set to study the contribution of RHI/TBI and SDOH in an underrepresented group and inform on potential racial disparities and associated causes of later life neurological outcomes diagnosis at the individual-level.isease detection and

PI_NAMEs: TURNER, ROBERT W. (contact)

PROGRAM_OFFICER_NAME: UMOH, NSINI ALEASE

PROJECT_TERMS: Accelerometer;Adult;adverse childhood events;Affect;Age;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;American;Amyloid beta-Protein;Atrophic;Biological Assay;Biological Markers;Black American;black men;Black Populations;Black race;Blood;Boston;Brain;brain health;Cerebrospinal Fluid;Childhood;chronic traumatic encephalopathy;Cognition;Cognitive;cognitive function;Collaborations;contact sports;Data;Data Set;Detection;Diagnosis;Diffusion;Disease;Disparity;dosage;Dose;Economics;Education;education access;Enrollment;Environment;Equation;experience;Exposure to;Face;Frequencies;Goals;head impact;Health;health care availability;health care quality;Hippocampus;Impaired cognition;indexing;Individual;instrument;Late Effects;late life;Life;Light;Link;Magnetic Resonance Imaging;Manufactured football;Mediating;men;Modeling;Neighborhoods;Nerve Degeneration;Nervous System Disorder;Neurobehavioral Manifestations;Neurodegenerative Disorders;neurofilament;Neurologic;Neurological outcome;neuropsychiatric symptom;neuropsychiatry;older adult;Outcome;Participant;Pathway interactions;PhenX Toolkit;Plasma;Play;Positioning Attribute;Poverty;Proteins;Publishing;Questionnaires;racial disparity;racial identity;recruit;Research;resilience;Resistance;response;Risk;Risk Factors;Role;Severities;social factors;social health determinants;Surveys;tau-1;Tauopathies;Testing;Traumatic Brain Injury;Underrepresented Populations;Universities;Washington;Wellness Program;white matter;White Matter Hyperintensity

PROJECT_TITLE: The Contribution of Repetitive Head Impacts and Social Determinants of Health to Alzheimer's Disease and Related Dementia in Older Adult Black Men

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Depression;Dietary Supplements;Lung;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Nutrition;Serious Mental Illness;Suicide

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Project Narrative A wide array of evidence suggests that relative hypoxia due to medical conditions or high altitude may contribute to major depressive disorder, possibly by causing deficits in brain energy metabolism and serotonin synthesis. The study proposed here is a randomized, double-blind, three-armed clinical trial of combination treatment with two supplements—5-hydroxytryptophan and creatine—that could improve those deficits in subjects with depression who have responded poorly to traditional antidepressants and are living at high altitude. The study uses phosphorus magnetic resonance spectroscopy and resting state functional connectivity imaging to assess physiologic correlates of treatment response, and measures blood serotonin levels to determine how they are altered by the supplements. !

PI_NAMEs: KIOUS, BRENT MICHAEL (contact);RENSHAW, PERRY FRANKLIN

PROGRAM_OFFICER_NAME: WEBER, WENDY J

PROJECT_TERMS: 5-hydroxy-tryptophan;Affect;Altitude;Amygdaloid structure;Animals;anti-depressive agents;Asthma;Award;Bioenergetics;Biological;Biological Markers;Blood;Brain;Brain Stem;Chronic;Chronic Obstructive Pulmonary Disease;cingulate cortex;Clinical;clinical care;clinical outcome measures;Clinical Trials;Combined Modality Therapy;comparison control;completed suicide;Creatine;Creatine Supplement;depressed patient;depressive symptoms;Development;dietary supplements;disability;Disease;Double-Blind Method;effectiveness evaluation;emotion regulation;Energy Metabolism;Epidemiology;Exhibits;frontal lobe;Functional Magnetic Resonance Imaging;Funding;Hamilton Rating Scale for Depression;Health;high risk;Hippocampus;Hypoxia;Image;improved;inorganic phosphate;Intervention;Intervention Studies;Link;Magnetic Resonance Spectroscopy;Major Depressive Disorder;Measures;Mediating;Medical;Mental Depression;Metabolism;Mitochondria;Moods;mortality;N-acetylaspartate;National Center for Complementary and Integrative Health;Natural Supplement;neurochemistry;novel;Nucleotides;Oral;Outcome;Oxygen;Participant;Patients;Persons;Phase;Phosphocreatine;Phosphorus;Physiological;Placebo Control;Prevalence;Production;Productivity;Prosencephalon;Protons;Randomized;Research;residence;Resistance;response;Rest;Risk;Rodent;Sea;Selective Serotonin Reuptake Inhibitor;Serotonin;Smoking;sociodemographic factors;suicidal risk;Suicide;Suicide attempt;suicide rate;Supplementation;treatment group;treatment response;tripolyphosphate;Tryptophan;Tryptophan 5-monooxygenase;United States;Utah;Whole Blood;Work

PROJECT_TITLE: 31P-MRS and resting state functional connectivity analysis of the effects of 5-hydroxytryptophan and creatine for antidepressant augmentation in patients with SSRI/SNRI-resistant major depressive diso


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;Infectious Diseases;Orphan Drug;Prevention;Rare Diseases;Vector-Borne Diseases;Zika Virus

ORG_CITY: UNIVERSITY PARK

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

PHR: This project is relevant to public health because flaviviruses are reemerging arthropod-borne viruses that infect millions of people annually and cause hemorrhagic fever, congenital abnormalities, and fatal encephalitis. Despite the urgent global public health need to control these infections, there are no antivirals or licensed vaccines for most flaviviruses, and many aspects of the flavivirus assembly and replication process remain elusive. This proposal will advance our mechanistic understanding of flavivirus assembly by defining the critical roles of structural and nonstructural proteins and their interactions to identify novel targets and strategies to combat these vector-borne diseases, contributing to NIAID’s mission to understand, treat, and prevent infectious diseases.

PI_NAMEs: JOSE, JOYCE  (contact)

PROGRAM_OFFICER_NAME: GAUTAM, RAJEEV

PROJECT_TERMS: Address;Affect;Affinity;Affinity Chromatography;Amino Acids;Anti-viral Agents;aptamer;Architecture;arthropod-borne;Binding;Biological Assay;Candidate Disease Gene;candidate selection;Capsid;Capsid Proteins;Cell Line;Cells;Cellular Membrane;Cellular Structures;Clustered Regularly Interspaced Short Palindromic Repeats;combat;Communicable Diseases;Complex;confocal imaging;Congenital Abnormality;Coupled;Data;Dengue;Dengue Virus;design;Disease;electron tomography;Encephalitis;Endoplasmic Reticulum;Experimental Designs;Fetus;Flavivirus;Flavivirus Infections;Gene Proteins;Genes;Genome;genome-wide;genomic RNA;Genomics;Golgi Apparatus;Guide RNA;Human;Image;Imaging Techniques;Infection Control;Integration Host Factors;Intervention;Kinetics;knock-down;Knowledge;Label;Libraries;Licensing;Mango - dietary;Mass Spectrum Analysis;Maternal-Fetal Exchange;Mediating;Membrane;Methodology;Microcephaly;Microtubules;Mission;Modeling;Modification;molecular imaging;Molecular Virology;Mothers;mutant;mutation screening;National Institute of Allergy and Infectious Disease;Nonstructural Protein;novel;Nuclear;Nuclear Structure;Organelles;Pathway interactions;Peptide Hydrolases;Persons;Placenta;Powassan virus;prevent;Process;Production;protein biomarkers;Proteins;Protocols documentation;Public Health;recruit;Replication-Associated Process;Reporting;retrograde transport;RNA;RNA Binding;RNA replication;RNA-Protein Interaction;Role;single molecule;Site;small hairpin RNA;Small Interfering RNA;spatiotemporal;Structural Protein;Structure;targeted treatment;Testing;Therapeutic Intervention;tool;trafficking;Transmission Electron Microscopy;transmission process;Vaccines;Vector-transmitted infectious disease;Vesicle;Viral;Viral Genome;Viral Hemorrhagic Fevers;Viral Proteins;viral RNA;viral transmission;Virion;Virus;Virus Assembly;Virus Diseases;virus host interaction;virus identification;Visualization;West Nile;Work;Yellow Fever;ZIKA;Zika Virus;ZIKV infection

PROJECT_TITLE: Defining the molecular interactions required for flavivirus genome packaging and virus assembly

STUDY_SECTION: MCV

STUDY_SECTION_NAME: Molecular and Cellular Biology of Virus Infection Study Section[MCV]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Services;Networking and Information Technology R&D (NITRD);Pediatric;Rehabilitation;Telehealth

PHR: Project Narrative This clinical trial will test the effectiveness of a smartphone-based mobile health (mHealth) system called UseIt! as both a standalone and coach-assisted intervention. The UseIt! mHealth system includes both an app and online portal and is designed to work by promoting skills-practice. The project has the potential to increase access to care by boosting the reach and scalability of skills-based psychosocial interventions for childhood behavior problems.

PI_NAMEs: LINDHIEM, OLIVER JAMES (contact)

PROGRAM_OFFICER_NAME: ESPOSITO, LAYLA E

PROJECT_TERMS: Aftercare;Age;Behavior;Cellular Phone;Child;Child Rearing;Childhood;Clinical;clinical practice;Clinical Trials;Cognitive Therapy;comparison intervention;cost;design;diaries;digital treatment;Effectiveness;effectiveness evaluation;effectiveness study;effectiveness testing;Electronics;Evidence based treatment;Failure;Family;follow-up;Foundations;Funding;Goals;Grant;Health;Health Services Accessibility;Health system;Intervention;Investigational Therapies;Knowledge;Libraries;Link;Measures;mHealth;Mission;National Institute of Child Health and Human Development;Outcome;Outcome Assessment;Parents;pilot trial;Population;Problem behavior;Productivity;psychosocial;Randomized;Randomized, Controlled Trials;reduce symptoms;remote therapy;satisfaction;scale up;skill acquisition;skills;skills training;social stigma;Symptoms;System;Therapeutic;Training;Transportation;Treatment Failure;United States National Institutes of Health;Validation;web portal;Work

PROJECT_TITLE: Reach and Scalability of Digital Therapeutics for Childhood Behavior Problems

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


ADMINISTERING_IC: EY

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Infectious Diseases;Macular Degeneration;Neurodegenerative;Neurosciences;Prevention

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: PROJECT NARRATIVE/RELEVANCE AMD is a major cause of visual impairment and blindness in the US. Antiretroviral-treated HIV- infected persons have accelerated and accentuated aging, including AMD. This proposal’s unprecedented availability of cryopreserved specimens in both HIV-infected and HIV-uninfected cohorts provides a unique opportunity to evaluate the immune response and inflammation in the pathogenesis of AMD, including correlating systemic inflammation with AMD risk genes.

PI_NAMEs: JABS, DOUGLAS A (contact)

PROGRAM_OFFICER_NAME: GORDIYENKO, NATALIYA

PROJECT_TERMS: Acceleration;Acquired Immunodeficiency Syndrome;Age;age acceleration;age related;Age related macular degeneration;Age Years;age-related disease;aged;Aging;AIDS population;Anti-Retroviral Agents;antiretroviral therapy;Biological;Biological Markers;Biology of Aging;biomarker identification;Blindness;Blood;Blood specimen;Bone Diseases;C-reactive protein;Cardiovascular Diseases;case control;CD14 gene;CD8-Positive T-Lymphocytes;chemokine;clinical application;cohort;Cohort Studies;Collaborations;Complement;Complex;Cryopreservation;Data;Defect;Deposition;design;Development;Drusen;Epidemiology;Ethnic Origin;Eye diseases;FCGR3B gene;Gender;genetic epidemiology;Genetic Polymorphism;Genomics;HIV;human old age (65+);Immune;immune activation;Immune response;Immune system;Immunologics;immunosenescence;improved;Incidence;Inflammation;Inflammatory;Interleukin-6;Laboratories;Leukocytes;life span;Longitudinal Studies;Malignant Neoplasms;Metabolic Diseases;Molecular Genetics;monocyte;Morbidity - disease rate;mortality;National Eye Institute;novel;Older Population;Opportunistic Infections;Organism;Pathogenesis;Pathway interactions;Patients;Persons;Phenotype;Plasma;Population;Prevalence;Proteomics;Race;Risk;Risk Factors;risk variant;Role;senescence;Serum;Specimen;systemic inflammatory response;T-Cell Depletion;Time;United States;Update;Vaccines;Visual impairment

PROJECT_TITLE: Immunologic Determinants of Age-Related Macular Degeneration (AMD)

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]


NIH_SPENDING_CATS: Breastfeeding, Lactation and Breast Milk;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Maternal Health;Maternal Morbidity and Mortality;Nutrition;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: PROJECT NARRATIVE This proposal is to continue the partnership of the University of Virginia and the icddr,b in Bangladesh as a Research Unit (RU) within the Global Network for Women’s and Children’s Health Research. The UVa-icddr,b RU will continue to add innovative and complementary expertise in infectious diseases, vaccinology, neonatal health, immunology, and human genetics to the robust strengths of the Network. The RU will build on the 30- year history of co-leadership of clinical studies by the PI Dr. Petri and SFI Dr. Haque, and the rich history of sustainable improvements in maternal-child health through the icddrb (most notably the invention and implementation of oral rehydration solution), to help achieve the Network goals.

PI_NAMEs: PETRI, WILLIAM A (contact)

PROGRAM_OFFICER_NAME: CHAKHTOURA, NAHIDA ABDO

PROJECT_TERMS: Address;Adherence;Adoption;Anemia;Azithromycin;Bacteriuria;Bangladesh;Birth;Budgets;Cellular Phone;Child;Child Development;Child Health;Childbirth;Childhood;Clinical Protocols;Clinical Research;Clinical Research Protocols;clinical research site;Clinical Trials;Clinical Trials Design;Clinical Trials Network;Communicable Diseases;Communities;community based care;Conduct Clinical Trials;Country;COVID-19;data centers;data communication;design;Development;Diarrhea;dietary supplements;electronic data;Enrollment;Environment;Equipment;Equity;equity, diversity, and inclusion;Ethical Review;Ethics;experience;Fertility;follow-up;Gender;gender-based violence;global health;Goals;Government;Grant;Health;Health care facility;health of the mother;Hospitals;Human Genetics;Human Resources;Human Rights;Immunology;Impairment;implementation science;improved;Income;Infant;Infant Malnutrition;innovation;Inservice Training;International;invention;Kinetics;Laboratories;laboratory facility;Lactation;Leadership;Low Birth Weight Infant;Mainstreaming;Maternal and Child Health;Maternal Mortality;Maternal-fetal medicine;Modeling;Mothers;multidisciplinary;National Institute of Child Health and Human Development;neonatal health;Neonatal Mortality;Neonatology;Neurocognitive;neurodevelopment;novel;nutrition;Occupational activity of managing finances;Oral;Outcome;Outcome Study;Paper;pediatric pharmacology;Pharmacodynamics;Pharmacology;Policies;Population;Pregnancy;Pregnant Women;prevent;Principal Investigator;Protocols documentation;Publications;Publishing;Recording of previous events;recruit;Registries;Rehydration Solutions;Reproductive Health;Research;Research Personnel;Reservations;Respiratory Tract Infections;Role;Rural;Rural Population;SARS-CoV-2 infection;Science;Scientist;Sepsis;Services;Site;Structure;Training;Translations;Underrepresented Minority;Universities;Urban Population;vaccine failure;vaccinology;Virginia;Visit;Woman

PROJECT_TITLE: NICHD Global Network for Women’s and Children’s Health Research: Research Units


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Colorectal Cancer;Digestive Diseases;Genetics;Human Genome;Precision Medicine

ORG_CITY: BUFFALO

ORG_NAME: ROSWELL PARK CANCER INSTITUTE CORP

PHR: PROJECT NARRATIVE The proposal investigates a novel therapeutic strategy for management of aggressive p53-deficient colorectal cancer. This novel therapeutic strategy is based on our inducer-amplifier concept for selective damaging of deadly cancer carrying a genetic abnormality commonly found in most solid tumors. Our work provides a novel and immediately feasible plan for treatment of patients with p53-deficient CRC using a combination of FDA- approved clinical drugs that have never been combined before.

PI_NAMEs: FOUNTZILAS, CHRISTOS  (contact)

PROGRAM_OFFICER_NAME: OLKHANUD, PUREVDORJ BALJINNYAM

PROJECT_TERMS: Amplifiers;analog;Antineoplastic Agents;Biological Markers;biomarker driven;biomarker identification;biomarker selection;Blood;BRAF gene;cancer cell;Cancer Model;Cell Death;Cells;Chromatin;Chromatin Structure;Clinical;clinical application;clinical biomarkers;Clinical Data;clinical efficacy;clinical implementation;Clinical Trials;cohort;Colorectal Adenocarcinoma;Colorectal Cancer;Combined Modality Therapy;Data;Deoxyuridine;design;Development;DNA;DNA biosynthesis;DNA Damage;DNA damage checkpoint;DNA Repair;DNA Repair Disorder;Dose;Elements;Evaluation;FDA approved;first-in-human;follow-up;Future;G2 Phase;gene repair;Genes;Genetic Transcription;genome integrity;genome-wide;Genomics;Human;improved;inhibitor therapy;insight;Malignant Neoplasms;Metabolism;Modeling;Molecular Abnormality;mutant;Mutation;Neoplasm Metastasis;next generation sequencing;novel;novel drug combination;novel strategies;novel therapeutic intervention;Oncogenic;patient population;Patient Selection;Patients;Pharmaceutical Preparations;Pharmacotherapy;Phase;phase 3 study;Phase I Clinical Trials;Poly(ADP-ribose) Polymerase Inhibitor;pre-clinical;Pre-Clinical Model;pre-clinical research;predict clinical outcome;predictive marker;Predictive Value;Prognosis;prospective;Randomized;Refractory;Regimen;repaired;replication stress;Research;Resistance;response;response biomarker;Sampling;Scientist;side effect;Solid Neoplasm;Stress;Testing;Therapeutic;therapeutically effective;Thymidine;Time;Tissues;TP53 gene;transcriptome;treatment planning;treatment strategy;Trifluridine;tumor;tumor progression;uptake;Validation;Work

PROJECT_TITLE: Novel synthetic lethality strategy for TP53 mutant colorectal cancer

STUDY_SECTION: MCTA

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics A Study Section[MCTA]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Pediatric;Prevention;Serious Mental Illness;Women's Health Research

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: PROJECT NARRATIVE Risk for major depressive disorder (MDD) dramatically increases during adolescence, particularly for females, and although interpersonal stress generation is an established risk factor, it is essential to clarify the underlying mechanisms to improve early detection and prevention of depression risk. The current study will utilize a multi- wave prospective design to examine neural and real-world affective reactivity to negative social interactions as prospective predictors of interpersonal stress generation and subsequent increases in depression symptoms in female adolescents at elevated risk for depression. Ultimately, the elucidation of brain and behavioral mechanisms underlying interpersonal stress generation and subsequent depression risk in female adolescents may contribute to greater understanding of the etiology of adolescent depression and aid in identifying novel targets for intervention.

PI_NAMEs: FEURER, COPE  (contact)

PROGRAM_OFFICER_NAME: BECHTHOLT, ANITA JEAN

PROJECT_TERMS: Adolescence;Adolescent;Adult;Affective;affective neuroscience;Age;Area;Behavior;behavior prediction;Behavioral;Behavioral Mechanisms;Biological;Brain;career;Chicago;child depression;Coupled;Cues;Data;depression prevention;depressive symptoms;design;Detection;Development;disorder risk;Down-Regulation;Early Diagnosis;Ecological momentary assessment;Enrollment;Environment;Etiology;Exhibits;Family;Female;Female Adolescents;follow-up;Functional Magnetic Resonance Imaging;Future;Generations;girls;Goals;Grain;Grant;Illinois;imaging study;improved;indexing;Individual;Intervention;Interview;Life Stress;Link;Major Depressive Disorder;Mediating;Mediator;Mental Depression;Mentorship;Methodology;Modeling;Moods;Morbidity - disease rate;multilevel analysis;National Institute of Mental Health;negative affect;neural;neural correlate;neural patterning;Neurobiology;neuroimaging;neuromechanism;novel;Nucleic Acid Regulatory Sequences;Onset of illness;Parents;Patient Self-Report;peer;Peripheral;Prevention;Process;prospective;Recording of previous events;Recurrence;Regulation;Reporting;Research;response;Risk;Risk Factors;Role;Sampling;Self Assessment;skill acquisition;skills;social;social exclusion;Social Interaction;Social Processes;social stress;Statistical Methods;Stress;Stressful Event;stressor;Suicide;Techniques;Testing;theories;Time;Training;translational scientist;Universities;Variant;Work;Youth

PROJECT_TITLE: Brain-Behavioral Predictors of Interpersonal Stress Generation and Depression Risk in Adolescent Girls


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Clinical Research;Diabetes;Genetic Testing;Genetics;Human Genome;Orphan Drug;Pediatric;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: PROJECT NARRATIVE Relevance Congenital hyperinsulinism is a severe genetic disorder associated with high rates of neurodevelopmental impairment. This study will expand our understanding of the pathophysiology of hyperinsulinism and will facilitate the identification of new molecular mechanisms of disease and potential new therapeutic targets for this devastating disease. This study will improve our understanding of the mechanisms regulating insulin secretion in health and disease, and may benefit the development of new therapies not only for HI, but also for diabetes.

PI_NAMEs: DE LEON, DIVA D. (contact);GANGULY, ARUPA

PROGRAM_OFFICER_NAME: EGGERMAN, THOMAS L

PROJECT_TERMS: Affect;Affinity;Award;Beta Cell;Blood;Candidate Disease Gene;cell free DNA;Cell Physiology;Child;Chromatin;Chromatin Structure;Chromosome 10;Classification;Code;Constitution;deep sequencing;Detection;Development;Diabetes Mellitus;Disease;DNA;Evaluation;Exclusion;exome;exome sequencing;Family;Functional disorder;Gene Expression;Genes;Genetic;Genetic Diseases;genetic linkage analysis;genetic pedigree;genetic testing;genome sequencing;genomic locus;Genomics;Genotype;Glucose;glucose-regulated proteins;Grant;Health;hexokinase;Hyperinsulinism;Hypoglycemia;improved;Individual;Infant;Inherited;insulin secretion;islet;Islets of Langerhans;Lead;Maps;maturity onset diabetes of the young;Molecular;Molecular Conformation;Molecular Genetics;Mutation;Neurodevelopmental Impairment;new therapeutic target;next generation sequencing;novel;novel therapeutics;Nuclear;Operative Surgical Procedures;Pancreas;Pancreatectomy;Pathogenicity;Patients;Persistent Hyperinsulinemia Hypoglycemia of Infancy;Phenotype;phosphatidylinositol 3'-kinase-associated serine kinase;Phosphotransferases;Protein Kinase;Regulation;Role;Somatic Mutation;success;Testing;Tissues;Untranslated RNA;Variant

PROJECT_TITLE: Islet Dysregulation in Infants with Congenital Hyperinsulinism


ORG_CITY: Chicago

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative: The regulation of protein diversity is a highly orchestrated process involving co-translation of transcripts and nascent proteins to their post-translation modifications. However, our understanding of co-translational processes in the maintenance of cellular signaling networks in the physiological environment lags compared to our understanding of genomic regulation. Applying a novel discovery approach that simultaneously examines the activity translating transcriptome and proteome within cells, we will investigate the co-translational and post- translational regulation of proteins expressed within angiogenesis signaling networks in the endothelial of the heart as they change with age and gender in vivo.

PI_NAMEs: GOLDSPINK, PAUL H (contact)

PROGRAM_OFFICER_NAME: GAO, HONGWEI

PROJECT_TERMS: Adult;Affinity Chromatography;Age;age related changes;age-related disease;Aging;aging related;angiogenesis;Basic Science;Blood capillaries;Body System;cardiac aging;Cardiovascular Diseases;cardiovascular injury;Cardiovascular system;Cell Communication;Cell Line;Cell model;Cell Separation;cell type;Cells;Characteristics;Complex;Coronary;Coupling;Data;Data Set;Development;Diagnosis;Embryonic Development;Endothelial Cells;Endothelium;Environment;Enzymes;Eukaryotic Cell;Event;Gender;gender difference;Gene Expression;genetic manipulation;genetic regulatory protein;Genetic Transcription;Genomics;Goals;Gonadal Steroid Hormones;Growth;Heart;Hypertension;Impairment;in vivo;innovation;intercellular communication;Investigation;Knowledge;Label;Life;Ligands;Maintenance;Mammalian Cell;Mediating;Mediator;Messenger RNA;Molecular;Molecular Chaperones;mRNA Translation;Myocardial Infarction;Neonatal;novel;Organ;Organism;Pathologic;Pathology;Pathway interactions;Physiological;Play;polypeptide;Polyribosomes;Post-Translational Protein Processing;Post-Translational Regulation;postnatal;Process;Production;Prokaryotic Cells;Proteins;Proteome;Proteomics;proteostasis;receptor;Regulation;response;response to injury;Ribosomes;Role;Scheme;sex;Shapes;Signal Pathway;Signal Transduction;Stimulus;Stress;Stroke;System;Technology;Testing;Transcript;transcriptome;transcriptomics;Translating;Translational Regulation;Translations;wound healing;Yeasts

PROJECT_TITLE: Co-translational Regulation in the Vasculature of Organ Systems with Aging

STUDY_SECTION: BBHV

STUDY_SECTION_NAME: Basic Biology of Blood, Heart and Vasculature Study Section [BBHV]


ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Project narrative: Inter-chemical correlations in exposomics core datasets enable linking the exposome chemical space with human health. The Exposome Correlation and Interpretation Database (ECID), a new biomedical knowledgebase will provide curated inter-chemical correlations and online portals to explore, analyze and interpret them in exposomics datasets.

PI_NAMEs: BARUPAL, DINESH  (contact);TEITELBAUM, SUSAN L

PROGRAM_OFFICER_NAME: DUNCAN, CHRISTOPHER GENTRY

PROJECT_TERMS: Advisory Committees;Affect;analytical method;Atlases;Biochemical;Biochemical Pathway;Biochemical Reaction;Bioinformatics;Biological Assay;Biological Markers;Biological Monitoring;Blood;Carcinogens;Cardiovascular Diseases;Catalogs;Chemical Exposure;Chemical Industry;Chemicals;cheminformatics;commensal microbes;Communities;community engagement;Complement;Data;Data Analyses;Data Analytics;data centers;data exploration;Data Provenance;data resource;Data Set;Databases;Development;Disease;Endocrine Disruptors;Engineering;Ensure;Environmental Exposure;Enzymes;Exposure to;Genes;Genome;Graph;hazard;Health;host microbiota;Human;Human body;Industrialization;insight;instrument;knowledgebase;Laboratories;Link;Liquid Chromatography;Literature;Malignant Neoplasms;Maps;Mass Fragmentography;Mass Spectrum Analysis;Measures;MeSH Thesaurus;Metabolic;Metabolic Pathway;metabolome;metabolomics;Methods;National Health and Nutrition Examination Survey;Nervous System Disorder;novel;Nutrient;Ontology;Pathway interactions;Pharmaceutical Preparations;Population;programs;prototype;Publishing;Reaction;repository;Research;Research Personnel;Resolution;Resource Informatics;Resources;Respiratory Disease;Risk Factors;small molecule;Source;Surveys;text searching;tool;trustworthiness;tumor progression;United States National Institutes of Health;user-friendly;Validation;validation studies;web portal;Work;working group;Xenobiotics


NIH_SPENDING_CATS: Breast Cancer;Cancer;Chronic Pain;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy;Prevention;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Women's Health Research

ORG_CITY: BOSTON

ORG_NAME: DANA-FARBER CANCER INST

PHR: Narrative Many cancer patients experience numbness and (paradoxically) pain caused by chemotherapy; these neurologic problems can be debilitating and severely compromise quality of life for too many people. To find ways of preventing these complications, we investigate how chemotherapy causes these nerve problems. Our studies will analyze four new potential approaches for treatment that should prevent pain and improve the quality of life for cancer patients and survivors.

PI_NAMEs: SEGAL, ROSALIND A. (contact)

PROGRAM_OFFICER_NAME: CHEN, WEIWEI

PROJECT_TERMS: Address;Afferent Neurons;Aftercare;Alzheimer's Disease;antagonist;anterograde transport;Antimitotic Agents;Antineoplastic Agents;Axon;axonal degeneration;Axonal Transport;axonopathy;Binding;Calpain;Cancer Patient;Cancer Survivor;cancer therapy;Cells;chemotherapy;Chemotherapy-induced peripheral neuropathy;Complication;Cyclic ADP-Ribose;Cytoplasmic Granules;Data;Defect;Disease;effective therapy;Exhibits;experience;Family member;Foundations;Funding;Gases;Genetic study;Goals;Grant;hereditary neuropathy;Human;Immunocompetent;improved;induced pluripotent stem cell;Induced pluripotent stem cell derived human neuron;Induced pluripotent stem cell derived neurons;inhibitor;innovation;insight;Intervention;ITPR1 gene;Link;Malignant Breast Neoplasm;Malignant Neoplasms;Mediating;Messenger RNA;Microtubule Stabilization;Microtubules;mimetics;Modeling;Motor Neurons;mouse model;Mus;neoplastic cell;Nerve;Nerve Degeneration;nerve supply;Nervous System;Nervous System Physiology;Neurologic;Neurons;Neuropathy;novel strategies;novel therapeutic intervention;novel therapeutics;Numbness;optimal treatments;Paclitaxel;Pain;Pathologic;Pathway interactions;Patients;Peptide Hydrolases;Persons;Pharmaceutical Preparations;Predisposition;Presynaptic Terminals;prevent;Principal Investigator;Process;Production;prognostic indicator;Proteins;Quality of life;Resistance;Resources;retrograde transport;RNA Transport;Rodent;Role;Sensory;sulfated glycoprotein 2;Symptoms;taxane;Testing;Therapeutic;therapeutic target;Toxic effect;Translations;treatment response;tumor;tumor growth;Vinca Alkaloids;Withholding Treatment;Writing

PROJECT_TITLE: Axonal transport and chemotherapy induced peripheral neuropathy

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Dental, Oral, and Craniofacial Disease;Orphan Drug;Radiation Oncology;Rare Diseases

ORG_CITY: SAN FRANCISCO

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE Head and Neck Cancer is a public health concern in the United States and a major challenge in oncology. Hyperthermia combined with other treatments, such as radiation, chemotherapy, and immunotherapy, has been shown in clinical trials to increase response for head and neck cancer. The proposed project will develop methods for precise and practical hyperthermia delivery to head and neck cancer under magnetic resonance imaging control and tissue assessment to increase response rate and survival for patients with superficial and deep tumors in the head and neck, such as squamous cell carcinoma, melanoma, and soft tissue sarcoma of the head and neck region.

PI_NAMEs: KIM, KISOO  (contact)

PROGRAM_OFFICER_NAME: THIRUMANGALATHU, SHOBA

PROJECT_TERMS: Acoustics;Acute;Adopted;Aftercare;Algorithms;Anatomy;Area;Award;Blood flow;blood perfusion;Brain;Breathing;Canada;cancer therapy;cancer type;chemoradiation;chemotherapy;Chemotherapy and/or radiation;Clinical;Clinical Trials;Complex;cost;Dedications;Deglutition;Development;Dose;Drug Delivery Systems;Drug Sensitization;Evaluation;Excision;experience;experimental study;Feedback;Focused Ultrasound;Focused Ultrasound Therapy;Goals;Head and Neck Cancer;Head and neck structure;Health;Heating;high risk;Hyperthermia;hyperthermia treatment;Image;image guided;imaging modality;Immunotherapy;improved;in silico;interest;Knowledge;Location;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Malignant Neoplasms;Measurement;Mediating;Melanoma;Mentors;Metastatic Neoplasm to Lymph Nodes;Metastatic Neoplasm to the Bone;Methods;Monitor;Morphologic artifacts;Motion;Movement;Neck;new technology;Oncology;Outcome Study;Pancreas;Patients;Perfusion;Phase;Phase I Clinical Trials;Physiological;predictive modeling;Predisposition;prevent;Prostate;Public Health;Radiation;Radiation therapy;reconstruction;Research;Research Project Grants;response;Safety;safety and feasibility;Shapes;simulation;Site;Soft tissue sarcoma;Sonication;Spottings;Squamous cell carcinoma;standard of care;success;System;Techniques;Technology;Temperature;Therapeutic;Thermal Ablation Therapy;Thermometry;Time;Tissues;Toxic effect;Training;Transducers;translational scientist;treatment response;tumor;ultrasound;United States;Uterine Fibroids

PROJECT_TITLE: Advancing Methods for MR-guided Focused Ultrasound Hyperthermia for Head and Neck Cancer

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Emerging Infectious Diseases;Infectious Diseases;Orphan Drug;Prevention;Rare Diseases

ORG_CITY: HAYWARD

ORG_NAME: PLANET BIOTECHNOLOGY, INC.

PHR: Melioidosis, caused by the bacterial pathogen Burkholderia pseudomallei, is a major cause of morbidity and septic death in tropical/subtropical regions worldwide and has recently become endemic in the United States. It is particularly virulent in diabetic patients and is also considered a Tier 1 select agent due to its potential use as a bioweapon. We are developing as a therapeutic a recombinant protein that interferes with the bacterium’s natural ability to evade being killed by complement.

PI_NAMEs: WYCOFF, KEITH  (contact)

PROGRAM_OFFICER_NAME: LIU, BAOYING

PROJECT_TERMS: Animal Model;Anti-Bacterial Agents;Antibiotics;Antibody-Dependent Enhancement;arm;Bacteria;Binding;Biotechnology;bioweapon;Borrelia burgdorferi;Burkholderia pseudomallei;Cells;Cessation of life;Chimera organism;Classical Complement Pathway;Complement;Complement Activation;Complement Factor H;Complement Membrane Attack Complex;Cytoplasm;Data;Deposition;Development;diabetic patient;Drug Kinetics;Erythrocytes;Excision;experimental study;Fc Receptor;Generations;genetic regulatory protein;Goals;Gonorrhea;Grant;Human;human pathogen;IgG3;Immunoglobulin G;improved;In Vitro;in vitro testing;in vivo;Infection;Integration Host Factors;interest;Lead;Lyme Disease;Macrophage;Mediating;Melioidosis;Modification;Morbidity - disease rate;Mus;N-terminal;Natural Immunity;Natural Resistance;Neisseria gonorrhoeae;neutrophil;normal microbiota;Nose;novel therapeutics;pathogen;pathogenic bacteria;Pathway interactions;Phagocytes;Planets;Polysaccharides;Population;prevent;Preventive therapy;Proteins;Recombinant Proteins;Research Personnel;Resistance;Safety;septic;Serum;Surface;Sushi Domain;Testing;Therapeutic;therapeutic target;United States;Universities;uptake;vaccine access;Variant;Virulent;Work

PROJECT_TITLE: Factor H Fc fusions as novel therapeutics for Burkholderia pseudomallei infections

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DCAI-F(12)]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Neurosciences;Pediatric;Prevention;Psychosis;Schizophrenia;Serious Mental Illness;Social Determinants of Health

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

PHR: PROJECT NARRATIVE The current application will make important advances in understanding the nature of early markers of risk for psychotic disorders such as schizophrenia, otherwise known as psychotic-like experiences. Specifically, we do not yet understand why some individuals go on to develop more severe forms of psychotic-like experiences (i.e., sustained distressing psychotic-like experiences) and why for some individuals these experiences are transient. The current application will make significant strides in understanding the most important factors (such as family history and cognition) distinguishing sustained from transient distressing psychotic-like experiences, as well as understanding the clinical importance of these symptoms (including how many individuals with sustained distressing psychotic-like experiences seek treatment or have problems in school or at homes as a result of these symptoms).

PI_NAMEs: KARCHER, NICOLE R. (contact)

PROJECT_TERMS: 11 year old;Address;Adolescence;Adolescent;Adult;adverse childhood events;Age;aged;Area;attenuated psychosis syndrome;Award;base;Behavior;Brain;career;Caregivers;Child;Childhood;Clinical;Clinical Investigator;clinically significant;Cognition;Cognitive;Cognitive deficits;cognitive development;cognitive function;Data;Data Collection;data modeling;Data Set;Detection;Deterioration;Development;Developmental Delay Disorders;Diagnosis;Disease;Distress;DSM-V;Early identification;Early Intervention;early psychosis;Education;Environmental Risk Factor;Epidemiology;Etiology;experience;Exposure to;Family;Family history of;Functional disorder;Functional impairment;Future;Home;Impairment;improved;Individual;Institution;Intervention;Interview;Knowledge;large scale data;Literature;longitudinal analysis;Machine Learning;machine learning method;Magnetic Resonance Imaging;marijuana use;Measures;Mental disorders;Mental Health;Mentors;Mentorship;Modeling;Motor;National Institute of Mental Health;Nature;neural;Neurobiology;neuroimaging;Neuropsychological Tests;Neurosciences;novel;Occupational;Parents;Participant;Prevention;preventive intervention;Psychopathology;Psychoses;psychosis risk;psychotic;Psychotic Disorders;psychotic-like experiences;Public Health;Recording of previous events;Reporting;Research;Research Project Summaries;Rest;Risk Assessment;Risk Factors;Risk Marker;risk prediction;Running;Schizophrenia;Schools;Site;skills;social;Speech;Structure;substance use;success;Symptoms;Syndrome;Techniques;Testing;theories;Thick;Time;Training;Youth

PROJECT_TITLE: Cross-sectional and longitudinal predictors of distressing psychotic-like experiences in childhood and adolescence


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Prevention

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative Autophagy is crucial for the maintenance of neuron homeostasis and is often disrupted in Alzheimer’s disease. However, precisely what the impact of impaired autophagy is on the progression of AD remains unclear. My proposed research will examine how autophagy in neurons and microglia can mitigate neuroinflammation and plaque formation, and will provide a foundation for me to establish an independent research group investigating autophagy in AD progression.

PI_NAMEs: GOLDSMITH, JULIET  (contact)

PROGRAM_OFFICER_NAME: MCGAVERN, LINDA

PROJECT_TERMS: Affect;aging related;Alzheimer's Disease;Alzheimer's disease related dementia;Amyloid beta-Protein Precursor;apolipoprotein E-4;Autophagocytosis;Autophagosome;Award;Biochemical;Brain;brain cell;Cell Communication;Cell model;cell type;Cells;Chronic;Coculture Techniques;Communication;Complement;Complex;cost;Data;Deposition;Diagnosis;Diagnostic;Disease;Disease Progression;Drug Design;Drug Targeting;Dynein ATPase;early detection biomarkers;Early identification;Endoplasmic Reticulum;experimental study;Foundations;Genetic;glial activation;Health;high resolution imaging;Homeostasis;Immune;Impairment;improved;In Vitro;induced pluripotent stem cell;Induced pluripotent stem cell derived neurons;Inflammation;Inflammatory;innovation;Intervention;Maintenance;Microglia;Microtubules;Mitochondria;Mitochondrial DNA;Modeling;Molecular;Molecular Biology;Mutation;Nerve Degeneration;Neurofibrillary Tangles;neuroinflammation;neuron loss;Neurons;new therapeutic target;novel marker;Organelles;Pathway interactions;Patients;pharmacologic;Phase;Phenotype;Postdoctoral Fellow;prevent;Process;Protein Secretion;Proteins;rational design;Reproducibility;Research;Risk;Risk Factors;risk variant;Role;Sampling;Societies;Stress;stressor;Supporting Cell;Synapses;System;tau aggregation;tau mutation;tau Proteins;Techniques;therapeutic target;trafficking;Variant;Work

PROJECT_TITLE: Inflammation and plaque formation downstream of disrupted autophagy in Alzheimer's disease


NIH_SPENDING_CATS: Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Infant Mortality;Lung;Opioid Misuse and Addiction;Opioids;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Rare Diseases;Sleep Research;Substance Misuse;Sudden Infant Death Syndrome

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Project Narrative Many babies are exposed before birth to opioid drugs taken by their mother during pregnancy. These infants often develop neonatal opioid withdrawal syndrome and are at higher risk of sudden infant death syndrome. In this project, we will use information on heart rate, breathing rate, and blood oxygen levels from soon after birth to predict which infants are at higher risk of developing neonatal opioid withdrawal syndrome, determine the severity of withdrawal and the response to treatment, and find abnormal breathing patterns that may increase the risk of sudden infant death.

PI_NAMEs: AMBALAVANAN, NAMASIVAYAM  (contact)

PROGRAM_OFFICER_NAME: GUMINA, DIANE LAURA

PROJECT_TERMS: addiction;Age Months;Alabama;antenatal;Apnea;Birth;Blood;Bradycardia;Brain;Breathing;Characteristics;Clinical;Clinical assessments;Clinical Research;clinical research site;cohort;Complex;Data;Detection;Development;Diagnosis;Doctor of Philosophy;Enrollment;Epidemic;Event;evidence base;Exposure to;follow-up;Goals;Heart Rate;high risk;high risk infant;Hospitals;Hypoxemia;improved;in utero;indexing;Infant;Knowledge;mathematical model;Measurement;Methadone;Methods;Modeling;Monitor;morphine administration;Mothers;Multicenter Neonatal Research Network;National Institute of Child Health and Human Development;Neonatal;Neonatal Abstinence Syndrome;neonate;Neurodevelopmental Impairment;Newborn Infant;Nursing Staff;Opioid;opioid exposure;opioid use;opioid withdrawal;Outcome;Oxygen;participant retention;Pattern;Pattern Recognition;Perinatal;Pharmaceutical Preparations;Physiological;Polysomnography;Pregnancy;Premature Infant;prevent;Productivity;programs;prospective;Prospective cohort;Research;Research Infrastructure;Research Personnel;respiratory;Risk;Severities;signal processing;Signal Transduction;Site;Sleep;Sleep Apnea Syndromes;statistics;Sudden infant death syndrome;Symptoms;System;Testing;Texas;Training;Translational Research;treatment response;Universities;Withdrawal

PROJECT_TITLE: Vital Signs In Opioid-Exposed Neonates

STUDY_SECTION: PN

STUDY_SECTION_NAME: Pregnancy and Neonatology Study Section[PN]


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: ATLANTA

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative The incidence of myopia, or near-sightedness, is increasing at an alarming rate, with significant public health implications due to myopia being a risk factor for multiple sight-threatening conditions. In this proposal we use a mouse model of myopia, together with novel techniques for measuring changes in tissue properties, to understand how critical ocular tissues (retina, choroid and sclera) communicate with one another to trigger the excess axial growth of the eye that causes myopia. The data we will generate, when combined with a novel modeling platform that we will also create, will lay the foundation for intervening in the development of myopia by modulating the effects of a key signaling molecule, all-trans retinoic acid, in the sclera.

PI_NAMEs: ETHIER, C ROSS;KANE, MAUREEN A;PARDUE, MACHELLE T. (contact)

PROGRAM_OFFICER_NAME: WIGGS, CHERI

PROJECT_TITLE: Mechanisms of axial elongation in myopia