NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Neurosciences

ORG_CITY: Newark

ORG_NAME: UNIVERSITY OF DELAWARE

ORG_STATE: DE

PHR: Project Narrative Although research has identified a link between psychopathology and cognitive decline, as well as the inverse causal effect, (i.e., degradation of biological and cognitive systems increasing risk for new or worsening psychopathology), investigation of a bidirectional relationship between psychopathology and cognition remains largely unstudied. The objective of this application is to investigate the bidirectional effects of psychological and cognitive processes over time in midlife to identify potential early signs of cognitive decline prior to the onset of neurodegeneration, which may in turn, reduce the likelihood of new or worsening psychopathology. The proposed training and research plans will develop the applicant’s program of research on the longitudinal interplay between psychopathology and cognition.

PI_NAMEs: STUMPS, ANNA  (contact)

PROGRAM_OFFICER_NAME: AVENILLA, FRANK R

PROJECT_TERMS: Address;Adolescence;Adult;Age;age acceleration;Aging;aging population;aging process;Area;behavior measurement;Behavioral;biological systems;Brain region;causal model;Cicatrix;Cognition;Cognitive;cognitive ability;cognitive capacity;cognitive change;cognitive control;Cognitive deficits;cognitive function;cognitive process;cognitive system;Communities;Coping Skills;Data;Data Analyses;Death Rate;Development;Early identification;Emotional;functional disability;Future;Goals;Growth;Health;Hydrocortisone;Impaired cognition;Individual;Influentials;Investigation;Knowledge;late life;Life Expectancy;life span;Link;Measures;Mental disorders;Mental Health;Methods;middle age;Modeling;multilevel analysis;National Institute of Mental Health;Nature;Nerve Degeneration;neural;neural correlate;Neurobiology;Neurocognitive;Neurocognitive Deficit;novel;Outcome;Participant;Pathway interactions;Physiological;premature;Process;programs;psychologic;Psychopathology;Reproducibility;Research;research in practice;Research Project Grants;Risk;Risk Factors;Risk Marker;Sampling;Severities;Short-Term Memory;societal costs;symptomatology;Symptoms;Techniques;Testing;Theoretical model;theories;Time;Training;training opportunity;Transact;trend;Work

PROJECT_TITLE: Multilevel analysis of the bidirectional effects of cognition and psychopathology over time


ADMINISTERING_IC: AI

ARRA_FUNDED: N

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Genetics;Infectious Diseases;Microbiome

ORG_CITY: WASHINGTON

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: CARNEGIE INSTITUTION OF WASHINGTON, D.C.

ORG_STATE: DC

PHR: PROJECT NARRATIVE Antibiotic treatment decreases the burden of bacterial diseases, but efficacy is often diminished when bacteria are in mixed microbial communities such as the microbiome. Lactic acid bacteria are a component of the microbiome; however, little is known about how these bacteria impact community physiology and how their growth is affected by small molecules from the community. The proposed study will determine the molecular mechanisms of how the growth of the lactic acid bacteria Lactiplantbacillus plantarum is coordinated and how this influences antibiotic sensitivities and community stability.

PI_NAMEs: SCHEFFLER, ROBERT JOHN (contact)

PROGRAM_OFFICER_NAME: XU, ZUOYU

PROJECT_TERMS: Acetates;Acetobacter;Address;Affect;Antibiotic Therapy;antibiotic tolerance;Antibiotics;Bacteria;Bacterial Infections;beneficial microorganism;biological adaptation to stress;Biological Models;career;Cell Physiology;Cessation of life;Chemicals;Communities;Complex;Cues;Cytoprotection;Defect;diarrheal disease;Drosophila genus;Drosophila melanogaster;Environment;Environmental Monitoring;experimental study;feeding;fitness;Foundations;Genes;Genetic;genetic approach;Genetic Complementation Test;Genetic Screening;Goals;Growth;gut microbiome;Health;Human;human microbiota;improved;Incidence;Individual;Infection;Knowledge;Laboratories;lactic acid bacteria;Lactobacillus plantarum;Malignant neoplasm of cervix uteri;Malignant neoplasm of gastrointestinal tract;Membrane;Metabolism;metabolomics;Microbe;microbial;microbial community;microbiome;microbiome components;Microscopic;Modeling;Molecular;Mucous Membrane;mutant;Mutation;Nucleic Acid Regulatory Sequences;Nutrient;Oxidation-Reduction;Pathway interactions;Phenotype;Physiological;Physiology;Plasmids;Point Mutation;Population;Probiotics;Production;promoter;Property;Public Health;Regulation;Reporter;Reproducibility;Research;Resistance to infection;respiratory microbiome;response;side effect;Signal Transduction;small molecule;Stimulus;System;Testing;transcriptome sequencing;Treatment Efficacy;vaginal microbiome;Volatile Fatty Acids;Work

PROJECT_TITLE: Coordinated growth in microbial communities and implications for antibiotic sensitivities

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F07A-B (20)]


ADMINISTERING_IC: AR

ED_INST_TYPE: GRADUATE SCHOOLS

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Genetics;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: NEW YORK

ORG_DEPT: BIOLOGY

ORG_NAME: ROCKEFELLER UNIVERSITY

ORG_STATE: NY

PHR: Project Narrative  The skin is continually exposed to the inflammatory stresses of the outside world. Following transient inflammation, the long-lived epithelial stem cells that maintain this barrier can retain lasting epigenetic memories that markedly heighten future responses to stress. This proposal will explore how allergic type 2 inflammation in skin specifically influences the long-term functionality of epithelial stem cells, both locally within sites of inflammatory pathology and systemically across the skin and airway epithelia.

PI_NAMEs: SAJJATH, SAIRAJ M (contact)

PROGRAM_OFFICER_NAME: VINCENT, ISAAH S

PROJECT_TERMS: Ablation;adaptive immune response;Address;age related;airway epithelium;Allergic;Allergic inflammation;Antibodies;Antigens;assault;Asthma;Atopic Dermatitis;Basophils;Binding;Biological Assay;Calcipotriene;Cell Compartmentation;Cell Separation;cell type;Cells;Chromatin;Chronic Disease;coping;Cues;cytokine;Data;Disease;Distal;Endowment;environmental stressor;epigenetic memory;Epigenetic Process;epithelial stem cell;Epithelium;experience;Exposure to;extracellular;fitness;Future;Generations;Genes;Genetic Transcription;graduate student;Hand;healing;Health;histone modification;Human Biology;Human Pathology;Hypersensitivity;IgE;Immune;Immunity;Immunologic Memory;Immunologic Sensitization;improved;In Vitro;in vivo;Inflammation;Inflammatory;insight;Interleukin-4;keratinocyte;Life;Light;long term memory;Lung;mast cell;Memory;Modernization;Molecular;NF-kappa B;novel;Organism;pandemic disease;pathogen;Pathologic;Pathology;Phenotype;Production;receptor;repaired;Resolution;response;Rhinitis;Shapes;Signal Transduction;Sinusitis;Site;Skin;skin barrier;stem cell function;stem cell population;stemness;Stress;stressor;systemic inflammatory response;targeted treatment;Testing;Tissues;Topical application;Tracheal Epithelium;Training;Transcript;transcription factor;treatment strategy;TSLP gene;Work;wound;wound healing

PROJECT_TITLE: Long-term systemic consequences of type 2 skin inflammation on epithelial stem cells

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F05-D (21)]


ADMINISTERING_IC: DC

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: GAINESVILLE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE Our sense of hearing relies crucially on the development and function of hair cell stereocilia in the cochlea, which act as vital mechanosensory structures responsible for detecting sound. The goal of this project is to understand the molecular mechanisms that ultimately determine the size and shape of stereocilia. By understanding this critical process, this research opens avenues for developing novel therapeutic strategies to improve hearing health and enhance the lives of individuals impacted by hearing-related conditions.

PI_NAMEs: MORELAND, ZANE G (contact)

PROGRAM_OFFICER_NAME: SCHURMAN, JACLYN REBECCA

PROJECT_TERMS: Acceleration;Actins;Address;Affect;aging process;Apical;Architecture;ATPase Domain;Auditory;Biological Assay;Biology;biophysical properties;Biophysics;Cartoons;Cell surface;cellular microvillus;Cochlea;Complex;Coupling;Cytoskeleton;Data;deafness;density;Development;Disabling;Disease;Elasticity;Elements;Ensure;Epidermal Growth Factor Receptor Pathway Substrate 8;experimental study;Filament;Fluorescence Microscopy;Fluorescence Recovery After Photobleaching;GNAI3 gene;Goals;GPSM2 gene;Growth;Hair Cells;Health;Hearing;hearing impairment;Height;hereditary hearing loss;Human;improved;In Vitro;in vivo;Individual;Inner Hair Cells;innovation;insight;interfacial;Length;Liquid substance;Loudness;Maintenance;Measures;mechanical properties;Mechanics;Membrane;Microfilaments;Microscopy;Modeling;Molecular;Molecular Motors;Monitor;Motor;Mutation;Myosin ATPase;neurochemistry;novel;novel therapeutic intervention;optic trap;optical traps;Optics;Outcome;Patients;Phase;Physical condensation;Play;polymerization;Polymers;Population;Predisposition;preservation;prevent;Process;Property;protein complex;protein purification;protein reconstitution;Proteins;Public Health;Publishing;Reaction;reconstitution;recruit;Regulation;Research;Rheology;Role;scaffold;Shapes;Signal Transduction;single molecule;sound;Spectrum Analysis;Stimulus;Structural Protein;Structure;Surface;Techniques;Testing;Therapeutic;therapeutic target;viscoelasticity;Viscosity;WHRN gene;Work

PROJECT_TITLE: Exploring the Biophysical Landscape of Tip Density Biomolecular Condensates in Mechanosensory Stereocilia

STUDY_SECTION_NAME: Special Emphasis Panel[ZDC1 SRB-Y (58)]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics;Neurosciences;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine

ORG_CITY: ANN ARBOR

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE Lens injury promotes robust and extensive retinal ganglion cell (RGC) survival and axon regeneration following injury, providing a unique and biologically relevant neuro-repair mechanism in the central nervous system. The proposed project will identify lens injury-elicited molecular mechanisms for neuro-repair towards RGCs. The results of this project will provide new knowledge on core neurorepair gene programs that may be targeted for the treatment of central nervous system injury and disease.

PI_NAMEs: FINNERAN, MATTHEW  (contact)

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: Acute;Adult;Affect;Astrocytes;ATAC-seq;Atlases;Axon;axon regeneration;Blindness;Brain;Candidate Disease Gene;candidate identification;Cell Death;cell growth;Cell Nucleus;cell regeneration;Cell Survival;cell type;Cells;Central Nervous System;central nervous system injury;Cessation of life;Chromatin;Communities;Computing Methodologies;conditioning;Crush Injury;Crystalline Lens;Crystallins;Cytoprotection;Data;Data Set;Development;Diabetic Retinopathy;Disease;Epithelial Cells;Exhibits;experimental study;Eye;Fibroblasts;gain of function;gene product;gene regulatory network;Genes;genetic approach;Genetic Transcription;Goals;Growth;healing;Human;Immunofluorescence Immunologic;in silico;In Vitro;in vitro regeneration;in vivo;in vivo regeneration;injured;Injury;insight;Intervention;intravitreal injection;Investigation;Knock-out;Knowledge;Label;lens;Lens development;loss of function;Mediating;Methods;Modeling;Molecular;mouse genetics;Muller's cell;multiple omics;Mus;Mutant Strains Mice;Natural regeneration;Nerve Crush;Nerve Fibers;Nervous System;Nervous System Trauma;Neurites;Neuroglia;Neurologic Deficit;neuronal circuitry;Neurons;neuroprotection;novel;online repository;operation;Optic Nerve;Optic Nerve Injuries;overexpression;Pathway interactions;Post-Translational Protein Processing;pre-clinical;programs;Proteins;Puncture procedure;Recombinants;regeneration following injury;regenerative;Regenerative capacity;Regenerative response;repaired;Reporting;Research;response to injury;Retina;Retinal Ganglion Cells;retinal neuron;Rodent;Rodent Model;Role;Signal Pathway;single nucleus RNA-sequencing;single-cell RNA sequencing;Site;targeted treatment;Testing;Therapeutic;Time;Tissues;Transcript;transcription factor;transmission process;visual information;α-Crystallins

PROJECT_TITLE: Lens injury-mediated mechanisms of nervous system protection and axon regeneration

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F03B-L (20)]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Genetics;Infectious Diseases;Microbiome;Nutrition;Pediatric;Prevention

ORG_NAME: GEORGETOWN UNIVERSITY

PHR: PROJECT NARRATIVE This project will explore the mechanism of epithelial cell repair following Giardia infection in order to determine how this contributes to growth-faltering in infected children. It may also help us understand barrier repair more broadly in conditions like environmental enteropathy and inflammatory bowel disease. Finally, it will provide opportunities for rigorous training in the design and execution of experiments and interpretation of data intrinsic to the career goals of the PI.

PI_NAMEs: KOSILE, RITA TAYE (contact)

PROGRAM_OFFICER_NAME: MOITRA, KAROBI

PROJECT_TERMS: 2 year old;acute symptom;Address;Amino Acids;Anabolism;Antibiotics;Aryl Hydrocarbon Receptor;aryl hydrocarbon receptor ligand;Biological Assay;Biomedical Research;career;Cells;Child;conditional knockout;contaminated water;Cytoskeleton;Data;Data Analyses;Defect;design;Diarrhea;diarrheal disease;Diet;Diet Modification;Disease;Duodenum;Epithelial Cell Proliferation;Epithelial Cells;epithelial repair;Epithelium;Exhibits;experimental study;ezrin;Failure to Thrive;Flow Cytometry;fluorescein isothiocyanate dextran;Food;Functional disorder;Genes;Giardia;Giardia lamblia;Giardiasis;Goals;Growth;gut bacteria;gut microbiome;Immune;Impairment;improved;Individual;Infection;Inflammatory Bowel Diseases;Ingestion;insight;interleukin-22;intestinal barrier;intestinal epithelium;Intestinal parasite;Intestinal permeability;Intestines;Irritable Bowel Syndrome;Knock-out;Knowledge;Leaky Gut;Link;Longitudinal cohort study;low and middle-income countries;low income country;Lymphocyte;Malabsorption Syndromes;Malnutrition;Mass Spectrum Analysis;Measures;Mediating;Messenger RNA;metagenomic sequencing;microbiome;microbiota;Modeling;mouse model;Mus;Nutrient;nutrient absorption;Outcome;Parasites;Pathogenesis;Patients;Permeability;Plasma;Population;Post-Translational Protein Processing;prevent;Production;Proliferating;promoter;Protein-Restricted Diet;Proteins;Receptor Activation;repaired;Research;Role;Signal Transduction;Small Intestines;Symptoms;Testing;Training;Transcript;Transgenes;Transgenic Organisms;transmission process;Tryptophan;Tyrosine;urinary;Urine;villin;Vomiting;Weight;Weight Gain;Western Blotting

PROJECT_TITLE: Intestinal Barrier Repair Mechanisms in Giardiasis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F07B-G (20)]


ADMINISTERING_IC: AG

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: BERKELEY

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

ORG_STATE: CA

PHR: Project Narrative The proposed project will investigate how functional connectivity between networks that harbor early Alzheimer’s disease (AD) pathology are related to AD risk, longitudinal AD pathology accumulation, and age. Although the co-occurrence of Aβ and tau pathology underlie AD, the mechanisms by which early forms of these proteins interact across spatially distant brain regions to promote AD progression are not well understood. Functional network connectivity may underlie these remote interactions and this project will provide insight into mechanisms that drive regional vulnerability to early pathological protein accumulation in aging and AD.

PI_NAMEs: FONSECA, CORRINA  (contact)

PROGRAM_OFFICER_NAME: SARE, RACHEL

PROJECT_TERMS: abeta accumulation;Age;age related;age related changes;Aging;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease risk;Alzheimer's disease therapeutic;Amyloid beta-Protein;Animals;apolipoprotein E-4;Area;Automobile Driving;Autopsy;Biometry;Brain;Brain region;Clinical;Cognition;cognitive neuroscience;Communication;connectome;Data;Data Analyses;data modeling;Deposition;Development;Disease;Disease Progression;Disparate;Distant;Early Diagnosis;Educational process of instructing;entorhinal cortex;Fellowship;Functional disorder;Functional Magnetic Resonance Imaging;Future;Goals;Human;Impaired cognition;Impairment;in vivo;Inferior;insight;Life;life span;Link;Measures;medial temporal lobe;Mediating;Memory;Mentors;Mentorship;multimodal neuroimaging;Neocortex;Nerve Degeneration;neuroimaging;Neurosciences;novel strategies;older adult;Parietal;Pathologic;Pathology;Pattern;Positron-Emission Tomography;Postdoctoral Fellow;Process;Property;Proteins;remote interaction;Research;Research Personnel;research study;Rest;Science;skills;spatiotemporal;statistics;Stereotyping;Symptoms;targeted treatment;tau aggregation;tau interaction;tau Proteins;tool;Training;Work;young adult

PROJECT_TITLE: Network drivers of regional vulnerability to early Alzheimer's disease pathology

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F01A-V (20)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Mental Health;Neurodegenerative;Neurosciences;Prevention;Sleep Research;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: IRVINE

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: PROJECT NARRATIVE Over 6.5 million Americans over the age of 65 currently live with Alzheimer’s disease: a debilitating neurodegenerative disorder characterized by significant cognitive deficits. Research shows that up to 40% of dementia risk is due to modifiable risk factors, including deficient sleep and cardiovascular risk factors that exacerbate Cerebral Small Vessel Disease (CSVD). This project examines the mechanisms linking CSVD to sleep and sleep-dependent memory deficits related to Alzheimer’s disease, and lays the groundwork for advancement of behavioral interventions, refinement of screening, and development of public health recommendations for patients with disordered or deficient sleep.

PI_NAMEs: BERISHA, DESTINY  (contact)

PROJECT_TERMS: actigraphy;Address;Alzheimer disease detection;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease risk;American;Apnea;Area Under Curve;Arousal;Behavior;Behavior Therapy;Biological;Biological Markers;Blood;Blood Vessels;burden of illness;cardiovascular risk factor;care seeking;career;Cerebral small vessel disease;cerebrovascular;Cerebrovascular system;Clinic;Clinical;Cognitive;cognitive change;Cognitive deficits;Collaborations;Computing Methodologies;Coupling;Data;Data Set;Dementia;dementia risk;density;Development;Digital Signal Processing;discrimination task;Disease;Disease Marker;early detection biomarkers;Electroencephalography;Funding;Goals;Grant;gray matter;Hemorrhage;Hippocampus;human old age (65+);Hypoxia;image processing;imaging biomarker;indexing;Individual;innovation;insight;Institution;Intervention;Investigation;Knowledge;Learning;Left;Length;Link;Magnetic Resonance Imaging;Measures;medial temporal lobe;Mediating;Memory;memory consolidation;Memory impairment;Mentorship;mild cognitive impairment;Modeling;Modernization;modifiable risk;multidimensional data;multimodality;Neurodegenerative Disorders;neuroimaging;neuroimaging marker;neurophysiology;new therapeutic target;non rapid eye movement;older adult;Participant;Pathogenesis;Patients;Pattern;Performance;Phase;Polysomnography;Predictive Value;Public Health;Pulse Oximetry;Recommendation;Research;Research Design;Research Personnel;Risk Factors;Risk Reduction;Role;Science;screening;Severities;Shapes;Signal Transduction;Sleep;Sleep Deprivation;Sleep Disorders;Sleep disturbances;Sleep Fragmentations;sleep health;sleep onset;sleep physiology;sleep quality;Sleep Stages;Sleeplessness;Statistical Methods;Statistical Models;Structure;Techniques;Testing;Time;Training;United States National Institutes of Health;vector;White Matter Hyperintensity;Wrist

PROJECT_TITLE: Cerebrovascular and neurophysiological mechanisms of sleep-dependent memory impairment in older adults at risk for Alzheimer's disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F01B-M (20)]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Social Determinants of Health

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Autism is linked to differences in predictive coding. Competing empirically-supported hypotheses of this link are complicated by phenotypic heterogeneity within autism and potential dissociation of how neural activity maps onto behavior between autism and typical development, particularly in social contexts. These experiments use both neural and behavioral measures of temporal prediction to assess these competing models while accounting for both heterogeneity and dissociation, enabling clinicians to more effectively use skills-based approaches to help autistic individuals achieve their social and relational goals.

PI_NAMEs: FRAM, NOAH ROY (contact)

PROGRAM_OFFICER_NAME: CORNELL, ASHLEY ROSE

PROJECT_TERMS: Adult;adult with autism spectrum disorder;Auditory;autism spectrum disorder;autistic;Automobile Driving;Behavior;behavior measurement;Behavioral;behavioral outcome;behavioral phenotyping;Brain;Characteristics;Child Development;Clinical;Code;Cognitive;Computer Models;Data;Development;Diagnosis;Dissociation;Electroencephalography;Environment;Etiology;Event;experience;experimental study;Eye;Eye Movements;flexibility;Foundations;Future;Goals;Heterogeneity;Human;Impairment;improved;Incidence;Individual;individuals with autism spectrum disorder;insight;Intervention;intervention effect;Investigation;Judgment;Knowledge;Link;Maps;Measurement;Measures;Mediating;Modality;Modeling;Movement;neural;neural correlate;neural model;Neurodevelopmental Disorder;neuroimaging;novel;Outcome;Participant;Patients;Pattern;Periodicity;Phenotype;Population;predictive modeling;preference;Process;programs;Psyche structure;Research;Role;sample fixation;scaffold;Scientist;Sensory;skills;social;Social Behavior;Social Development;Social Environment;Social Functioning;Specific qualifier value;Stimulus;Structure;Techniques;Testing;theories;Time;Update;Variant;visual tracking;Work

PROJECT_TITLE: Temporal prediction and social function:  Modeling neural and behavioral correlates of making predictions in time across typically-developing and austistic adults


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Biotechnology;Diabetes;Genetics

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE β-cell dysfunction is one of the major characteristics of type II diabetes (T2D). MafA is an essential transcriptional regulator of β-cell biology, and is necessary for glucose sensing and insulin secretion, but it is often dysregulated in β-cells in animal models and people with T2D. In this proposal, I test whether MafA acetylation affects the β-cell functional response to obesity.

PI_NAMEs: CHIRIKJIAN, MARGOT KAY (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Acetylation;Acetyltransferase;Activities of Daily Living;Affect;Alanine;Animal Model;Animals;Arginine;Beta Cell;Binding;Biological Assay;blood glucose regulation;Cell Line;Cell Physiology;Cells;Cellular biology;cellular transduction;Characteristics;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;Data;Deacetylation;diabetes pathogenesis;diabetic;experimental study;factor A;feeding;Functional disorder;functional loss;Gene Expression;Genes;Genetic Transcription;Glucose;Glucose tolerance test;Glutamic Acid;Glutamine;High Fat Diet;Human;Hyperglycemia;Impairment;improved;in vivo;Incubated;inhibitor;Insulin;Insulin Resistance;insulin secretion;islet;Knock-in Mouse;knockout animal;Knockout Mice;Lentivirus;liquid chromatography mass spectrometry;Luciferases;Lysine;Measures;migration;mimetics;mouse model;Mus;Mutate;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;Persons;Phosphorylation;Post-Translational Protein Processing;preservation;promoter;recruit;response;Role;Scanning;Serine;Sumoylation Pathway;Testing;Transactivation;transcription factor;transcriptome sequencing;transcriptomics;Wild Type Mouse

PROJECT_TITLE: Acetylation as a novel post-translational modification of MafA

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Fellowships in Diabetes Endocrinology and Metabolic Diseases [DDK-E]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Harm Reduction for Substance Misuse;Health Services;Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Primary Health Care;Substance Misuse

ORG_CITY: HANOVER

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: PROJECT NARRATIVE The opioid overdose crisis remains a critical public health threat and warrants an evidence-based approach to develop treatment and policy solutions. The proposed study will investigate whether a pharmacist-integrated model of medication treatment for opioid use disorder may increase primary care capacity for co-prescribing the overdose antidote, naloxone. The proposed training plan will provide the applicant with clinical trial methodological experience with the guidance of her sponsor and expert consultants.

PI_NAMEs: BOGGIS, JESSE S (contact)

PROGRAM_OFFICER_NAME: MARTIN, LINDSEY ANN

PROJECT_TERMS: Abstinence;Accounting;Administrator;Affect;Antidotes;Attitude;authority;career;Caring;Cessation of life;Characteristics;Clinic;clinical trial implementation;Clinical Trials;Clinical Trials Network;Computerized Medical Record;Consolidated Framework for Implementation Research;Data;demographics;Disease Management;Drug Controls;Drug Prescriptions;drug testing;Electronic Health Record;Equation;Evaluation;Event;evidence base;experience;FDA approved;Federally Qualified Health Center;Fentanyl;fentanyl analog;Formulation;Foundations;Goals;Harm Reduction;Health Insurance;high risk;illicit opioid;innovation;Institution;Insurance Carriers;integrated care;Intervention;Interview;Knowledge;Laws;Learning;Link;Literature;Maine;manufacture;Measures;medication for opioid use disorder;Mentors;Methodology;Modeling;mortality;multilevel analysis;Naloxone;naloxone dispensing;National Institute of Drug Abuse;opioid mortality;opioid overdose;opioid use disorder;Outcome;Overdose;overdose death;Overdose reduction;Parents;Participant;Patients;Persons;Pharmaceutical Preparations;Pharmacists;Pharmacy facility;Policies;Policy Analysis;prescription opioid;prevent;Primary Care;primary care team;Proliferating;Provider;Public Health;public health intervention;Recovery;Research;Research Design;Research Methodology;Research Project Grants;Research Support;response;Risk;Scanning;Scientist;Site;social stigma;Study models;synthetic opioid;Techniques;Test Result;Testing;Training;United States;Urine;US State

PROJECT_TITLE: Evaluation of a Pharmacist-Integrated Model of Opioid Use Disorder Treatment to Increase Naloxone Co-Prescribing in Primary Care

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F16-H (20)]


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences;Pediatric

ORG_CITY: ATLANTA

ORG_NAME: GEORGIA STATE UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative Processing visual input within its context is critical for cognition and perception and is altered in a number of neurological and neuropsychiatric disorders. This higher-order component of visual processing requires aspects of distributed brain circuitry which may not develop fully until adulthood. This project aims to explore how top-down projections to visual cortex from higher brain regions develop during adolescence with the goal of elucidating core neurobiological processes in healthy and pathological visual development.

PI_NAMEs: RADER GROVES, ANNA  (contact)

PROGRAM_OFFICER_NAME: CLAYTON, EDWIN C

PROJECT_TERMS: Adolescence;Adolescent;Adolescent Development;Adult;Advocacy;Anatomy;Anterior;Area;area striata;area V1;Axon;brain circuitry;Brain region;Calcium;Chronic;Cognition;cognitive ability;cognitive development;cognitive function;collaborative environment;Complex;confocal imaging;critical period;Data;density;Detection;Development;deviant;Disease;early adolescence;Electrophysiology (science);emerging adult;Exhibits;experience;Extramural Activities;Feedback;Future;genetic approach;Goals;Human;Image;in vivo;Injections;insight;Knowledge;lens;Literature;Measures;Mentorship;Modeling;mouse model;Mus;Neocortex;nerve supply;Nervous System Disorder;neural circuit;Neurobiology;neurodevelopment;Neurons;neuropsychiatric disorder;Neurosciences;novel;Pathologic;Perception;Phase;postnatal;postnatal period;Predisposition;Prefrontal Cortex;presynaptic;Process;PTPNS1 gene;Research;response;Rodent;Role;science education;Sensory;skills;Slice;ST5 gene;Stimulus;Synapses;Testing;Training;two photon microscopy;two-photon;Universities;Viral;vision development;Visual;Visual Cortex;visual feedback;Visual Fields;visual information;visual processing;visual stimulus;Visual System

PROJECT_TITLE: The adolescent development of top-down feedback for visual processing

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F02B-Y (20)]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Neurosciences;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_CITY: Nashville

ORG_NAME: VANDERBILT UNIVERSITY

PHR: PROJECT NARRATIVE Spinal cord injuries trigger complex secondary and chronic neuropathological effects, through neuroinflammatory activity and molecular changes at the spinal cord injury site, that can severely affect spinal cord regeneration and recovery. The proposed study will evaluate the use of multi-parametric MRI and PET imaging to characterize structural, functional, and molecular changes in spinal cord injuries over time, and identify biomarkers that relate to spinal cord injury severity and recovery progression. The multi-parametric imaging methods will be applied to evaluate the efficacy of novel spinal cord injury drug treatments and interventions.

PI_NAMEs: MU, CHAOQI CHASE (contact)

PROGRAM_OFFICER_NAME: MATTHEWS, MARGUERITE

PROJECT_TERMS: 3-Dimensional;Affect;Animal Model;Animals;Autopsy;Axon;behavior test;Behavioral;Binding;Biological Markers;biomarker identification;Cell Death;Chemicals;Chronic;Cicatrix;clinical translation;clinically relevant;Complex;Contusions;cytokine;Data;data exchange;Demyelinations;Development;diagnostic biomarker;Diffusion Magnetic Resonance Imaging;efficacy evaluation;excitotoxicity;Free Radicals;Functional Magnetic Resonance Imaging;Glutamates;gray matter;Growth;Histologic;histological stains;Human;Image;Image Enhancement;imaging modality;Immobilization;improved;Inflammatory;injured;Injury;innovation;interest;Intervention;macromolecule;Magnetic Resonance Imaging;Maps;Measurement;Measures;Methods;Modeling;Molecular;Motor;multimodality;multiparametric imaging;Myelin;neuroinflammation;neuropathology;Neuroprotective Agents;non-invasive imaging;novel;novel therapeutics;nuclear Overhauser enhancement;parametric imaging;Pathologic;Pharmaceutical Preparations;Pharmacology Study;Pharmacotherapy;Physiological;Positron-Emission Tomography;potential biomarker;pre-clinical;predictive modeling;Proteins;Protocols documentation;Protons;radiotracer;Rattus;Recovery;Recovery of Function;Relaxation;Reporting;Research;Resolution;Rest;Riluzole;Severities;Site;sodium ion;somatosensory;Spinal Cord;Spinal Cord Contusions;spinal cord imaging;Spinal cord injury;spinal cord regeneration;Spinal Injuries;Therapeutic Effect;Therapeutic Intervention;Time;Tissues;Treatment Efficacy;Validation;Water

PROJECT_TITLE: Multi-parametric MRI and PET imaging of rat spinal cord injury


FUNDING_MECHANISM: NON-SBIR/STTR RPGS

NIH_SPENDING_CATS: Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Data Science;Drug Abuse (NIDA only);Genetics;Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Neurosciences;Pediatric;Substance Misuse

ORG_CITY: BURLINGTON

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE

ORG_STATE: VT

PHR: PROJECT NARRATIVE The ENIGMA-Addiction consortium was established to investigate the genomic and neurobiological bases of problematic substance use by combining existing genomic and brain imaging datasets. Its goal is to maximize the yield from existing datasets through very large data pooling efforts thereby providing statistical power for rigorous and reproducible analyses. The renewal of funding will permit further expansion of this pooled database as a unique resource for the scientific community and provide support for comprehensive investigation of psychiatric comorbidities and identification of sub-groups of problematic substance use with differing etiology.

PI_NAMEs: GARAVAN, HUGH P. (contact)

PROGRAM_OFFICER_NAME: PARIYADATH, VANI

PROJECT_TERMS: addiction;Adolescent;Adult;analytical method;Anatomy;Anxiety;Area;Attention deficit hyperactivity disorder;base;Behavioral;biobank;Biological Markers;Brain;Brain imaging;cloud based;cohort;Communities;comorbidity;computerized data processing;cost effective;Country;cue reactivity;Data;Data Collection;data exchange;data harmonization;Data Pooling;Data Security;Data Set;data standards;Databases;Dependence;Diagnosis;Diagnostic;Diffusion;Disease;Ensure;Etiology;Excision;Failure;Functional Magnetic Resonance Imaging;Funding;Genes;Genetic;Genetic Risk;genome wide association study;Genomics;Goals;Health;high risk;HIV;Housekeeping;Human Resources;Income;Individual;individual variation;Infrastructure;insight;Institution;International;Investigation;Investments;large datasets;Lead;life span;Light;Link;low and middle-income countries;Machine Learning;machine learning classification;Magnetic Resonance Imaging;Measures;member;Mental Depression;Mental Health;Mentally Ill Persons;Methods;Mission;Modality;Modeling;multimodality;multiple datasets;Neurobiology;Neurocognitive;neuroimaging;open data;opioid user;outreach;Paper;Participant;Pattern;Peer Review;Performance;Pharmaceutical Preparations;Phase;Phenotype;Policies;Population;Post-Traumatic Stress Disorders;Protocols documentation;psychiatric comorbidity;psychologic;Publications;Quality Control;Recovery;Reproducibility;Research;Research Personnel;Research Project Grants;Resources;Rest;Risk;Risk Factors;Sample Size;Scanning;Science;Series;Sex Differences;shared database;Site;Standardization;Structure;Subgroup;Substance Addiction;substance use;substance user;success;supercomputer;Supercomputing;symposium;symptomatology;Thick;Universities;Vermont;working group;Youth

PROJECT_TITLE: ENIGMA- Addiction: Pooling of Existing Datasets to Identify Brain and Genetic Correlates of Addiction, Next Steps

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 LXF-E (J1)]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Hepatitis;Liver Disease;Prevention;Regenerative Medicine;Substance Misuse

ORG_CITY: LOUISVILLE

ORG_NAME: UNIVERSITY OF LOUISVILLE

ORG_STATE: KY

PHR: Project Narrative: This study will aim to exploit the liver’s ability to regenerate in order to reverse alcohol-induced liver damage common in alcoholic-associated liver disease (ALD) and alcohol-associated hepatitis (AH). Specifically, the study will determine whether preservation and/or supplementation of hepatic cardiolipin promotes liver regeneration in ALD/AH via multiple models (animal, in vitro, and human samples). Findings from this pre-clinical study will lead to the evaluation of the safety, dose tolerance, and efficacy of cardiolipin lipid vesicles and elamipretide as a treatment strategy for ALD/AH in clinical trials.

PI_NAMEs: HARDESTY, JOSIAH E (contact)

PROGRAM_OFFICER_NAME: LIN, LI

PROJECT_TERMS: Affect;Alcoholic Hepatitis;Alcoholic liver damage;Alcoholic Liver Diseases;Alcohols;alternative treatment;Animal Model;Animals;Apoptosis;ATP Synthesis Pathway;Binding;Bioenergetics;Biogenesis;Biological Assay;Biological Markers;Cardiolipins;Cells;Cessation of life;chronic liver disease;Clinical;Clinical Trials;Culture Media;cytochrome c;cytokine;Data;Death Rate;Dextrins;disorder control;Dose;Enzymes;Ethanol;Euthanasia;Evaluation;Experimental Animal Model;feeding;Foundations;Galactosamine;Genes;Genus Hippocampus;Hepatic;Hepatic Insufficiency;Hepatitis;Hepatocyte;hepatocyte injury;Human;Immune;Impairment;improved;In Vitro;in vitro Model;ineffective therapies;Inflammation;Inflammatory Response;Injections;Injury;Lead;lipidomics;Lipids;Liver;liver cell proliferation;Liver diseases;liver function;Liver Mitochondria;Liver Regeneration;liver transplantation;LoxP-flanked allele;Maintenance;male;Maltose;Measurement;Mediating;Mitochondria;mitochondrial dysfunction;mitochondrial membrane;Mitochondrial Myopathies;Modeling;Mus;Natural regeneration;novel;oxidation;Oxidative Phosphorylation;Partial Hepatectomy;particle;Pathway interactions;patient prognosis;Patients;Peripheral Blood Mononuclear Cell;Pharmaceutical Preparations;pharmacologic;Phase;Phospholipids;Plasma;Population;pre-clinical;preclinical study;preservation;prevent;Prevention;problem drinker;Process;Prognosis;Proliferating;Proliferation Marker;Proteins;Regimen;Research;Research Personnel;Respiratory Chain;response;restoration;Rodent;Role;Safety;Sampling;single-cell RNA sequencing;Solid;Sorting;Structure;Supplementation;Tail;Testing;Therapeutic;therapeutically effective;TNF gene;Training;Translations;treatment arm;Treatment Efficacy;treatment strategy;Veins;Vesicle;Viral;Viral Genome

PROJECT_TITLE: Restoration and preservation of hepatic cardiolipin levels promotes liver regeneration in AH

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Genetics

ORG_CITY: KANSAS CITY

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: Project Narrative Oxidative stress arising from exposure to environmental agents is a common cause of DNA damage that must be resolved by base excision repair to avoid the development of human disease. The goal of this project is to establish how the scaffold protein x-ray repair cross-complementing 1 (XRCC1) facilitates the activity of DNA polymerase beta (pol ꞵ) at DNA damage located in chromatin. This project will provide technical and professional training by using a unique combination of complementary assays to investigate how oxidative DNA damage is repaired.

PI_NAMEs: THOMPSON, SPENCER  (contact)

PROGRAM_OFFICER_NAME: SHAUGHNESSY, DANIEL

PROJECT_TERMS: Affinity;base;Base Excision Repairs;Binding;Biochemistry;Biological Assay;career;Catalysis;Cells;Chromatin;Communication;Complement component C1;Complex;Cryoelectron Microscopy;Development;Disease;Dissociation;DNA;DNA Binding;DNA Damage;DNA glycosylase;DNA lesion;DNA ligase III;DNA Polymerase β;DNA Repair;Electrophoretic Mobility Shift Assay;endonuclease;environmental agent;Environmental Exposure;Enzyme Kinetics;Enzymes;experimental study;Exposure to;Fellowship;Fluorescence;Fluorescence Microscopy;Foundations;Future;Genomic Instability;Goals;Histones;human disease;improved;innovation;inorganic phosphate;Kansas;Kinetics;laser tweezer;Lesion;Mediating;Medical center;Mentorship;Molecular;Mutation;Nature;Nucleosomes;Nucleotides;optic tweezer;oxidative damage;oxidative DNA damage;Oxidative Stress;Pathway interactions;Physicians;Play;Positioning Attribute;Predisposition;Process;Productivity;Proteins;Reactive Oxygen Species;recruit;repaired;Research;Roentgen Rays;Role;Scaffolding Protein;Scientist;seal;single molecule;Site;skills;Source;Structure;Supervision;Technical Expertise;Testing;Toxic Environmental Substances;Training;Universities;Writing

PROJECT_TITLE: Investigating XRCC1 coordination with DNA polymerase beta in chromatin during BER

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F04-S (20)]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease;Wound Healing and Care

PHR: After a heart attack, the immune system plays a critical role in the body’s healing process. This project seeks to determine if specific modes of immune cell production can determine their function and contribute to heart failure after a heart attack.

PI_NAMEs: STEPHAN, JONAH  (contact)

PROGRAM_OFFICER_NAME: CHEON, YEWON

PROJECT_TERMS: Acceleration;Acute;Adverse effects;Attention;Biological Markers;Biology;Bone Marrow;Cardiac;Cells;Cessation of life;chemokine;Cicatrix;Circulation;Clinic;Clinical;Collagen;cytokine;Cytoplasmic Granules;Data;Deposition;Echocardiography;Emergency response;Emergency Situation;Enzyme-Linked Immunosorbent Assay;Equilibrium;Exhibits;Extracellular Matrix;Faculty;Fellowship;Fibroblasts;Fibrosis;Flow Cytometry;Functional disorder;Future;Granulopoiesis;healing;Heart;Heart failure;heart function;Histologic;Immune;immune cell infiltrate;Immune system;Immunophenotyping;Impaired wound healing;Impairment;In Vitro;Infarction;Infection;Inflammation;Inflammatory;Inflammatory Response;Kinetics;Knowledge;Left;Left ventricular structure;life span;Macrophage;Measures;Mediating;member;Mus;Myocardial Infarction;Myocardial rupture;Myocarditis;Myocardium;neutrophil;Neutrophil Infiltration;novel;Outcome;Pathogenesis;peripheral blood;Phase;Phenotype;Physiology;Play;Population;Positioning Attribute;Postdoctoral Fellow;Preparation;Process;Production;Prognosis;Proliferating;Pump;Recovery;recruit;Research;response;Role;Segmented Neutrophil;Side;single-cell RNA sequencing;skills;stem cells;Stress;Technical Expertise;Testing;therapeutic target;tissue injury;Tissues;Training Programs;transcription factor;transcriptomics;Universities;Ventricular;Ventricular Function;wound healing

PROJECT_TITLE: The Role of Emergency Granulopoiesis in Wound Healing after Myocardial Infarction

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F10A-K (20)]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Cancer;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Genetics;Immunotherapy;Prevention;Rare Diseases

ORG_DEPT: DENTISTRY

PHR: PROJECT NARRATIVE Oral epithelial dysplasia precedes head and neck cancer, presenting an ideal window for early treatment, yet there are limited diagnostic criteria used to predict which lesions will progress to cancer. The interaction between the immune system and the tumor greatly informs treatment response and tumor progression, therefore, this project will investigate the modulation of the immune response at the onset of cancer initiation. This work will describe how immune cells are co-opted in precancerous lesions to promote tumor survival, providing critical information into key therapeutic interception points that may restore anti-tumor immunity at earlier stages of disease.

PI_NAMEs: TANER, HULYA  (contact)

PROGRAM_OFFICER_NAME: FUQUA, CHANTEL FAYSAN

PROJECT_TERMS: 3q26;Agonist;anakinra;antagonist;anti-tumor immune response;Atlases;Bone Marrow;cancer cell;cancer initiation;Cells;Chemistry;Chromatin;chromatin immunoprecipitation;Clinical;cytokine;Data;desensitization;Detection;Diagnosis;diagnostic criteria;dimensional analysis;Disease;Disease Progression;Early Diagnosis;Early treatment;effectiveness evaluation;Enterobacteria phage P1 Cre recombinase;Environmental Risk Factor;epigenetic marker;Epigenetic Process;Event;Evolution;Exposure to;FDA approved;Gene Activation;Gene Proteins;Genes;Genetic;genetic approach;genomic signature;Goals;Golgi Apparatus;Granulocyte-Macrophage Colony-Stimulating Factor;Head and Neck Cancer;Head and Neck Squamous Cell Carcinoma;high dimensionality;high risk;Histologic;histone methylation;HPV-negative head and neck cancer;Human;IL1R1 gene;Immune;immune cell infiltrate;Immune response;Immune system;Immune Tolerance;Immunologic Surveillance;immunoregulation;improved;Infiltration;Inflammation;innate immune pathways;innate immune sensing;insight;Intercept;Interferons;Interleukin-1;Interleukin-1 alpha;Interleukin-1 Receptors;Intraepithelial Neoplasia;keratin 5;Lesion;Macrophage;Malignant - descriptor;malignant mouth neoplasm;Malignant Neoplasms;Measures;Mediating;Modeling;Modification;Molecular;mouse model;Mus;Mutation;Myeloid Cell Activation;Myeloid Cells;Myeloid-derived suppressor cells;Nature;novel;Oncogenes;oral cavity epithelium;Oral mucous membrane structure;Paint;palmitoylation;Pathway interactions;Patient-Focused Outcomes;Patients;Pattern;pharmacologic;Phenotype;pre-clinical;Pre-Clinical Model;premalignant;prevent;Production;Proliferating;promoter;Proteins;Recording of previous events;recruit;Reporting;Research;Resolution;response;Role;Shapes;Signal Transduction;Site;Squamous cell carcinoma;Stimulator of Interferon Genes;Surface;Survival Rate;T-Cell Activation;T-Cell Proliferation;T-Lymphocyte;Tamoxifen;Testing;Therapeutic;Therapeutic Intervention;Time;Tissues;transcription factor;Travel;treatment response;tumor;Tumor Antigens;Tumor Burden;Tumor Immunity;tumor microenvironment;tumor progression;Tumor Promotion;Work

PROJECT_TITLE: Intercepting the Evolution of Pro-Tumoral Myeloid Cells During the Initiation of Oral Cancer

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Chronic Pain;Neurosciences;Pain Research

PHR: PROJECT NARRATIVE Flexible and protective withdrawal behaviors are essential for avoiding painful stimuli, but in pathological conditions people can become hypersensitive to pain or feel pain in response to otherwise innocuous sensory input. This proposal asks how properties of mechanosensory stimuli impact escape behavior and aims to understand how these signals may be integrated at the circuit level. This proposal will reveal potential mechanisms underlying behavioral flexibility in the context of escape and provide conserved insights for studying pain modulation at the cellular and circuit levels in analogous vertebrate systems.

PI_NAMEs: WOOD, ABBY  (contact)

PROJECT_TITLE: The Cellular and Neural Circuit Basis of Flexible Escape Behavior


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Genetics;Headaches;Human Genome;Migraine;Neurosciences;Opioid Misuse and Addiction;Opioids;Pain Research;Substance Misuse

ORG_CITY: CORAL GABLES

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE This study seeks to address the growing opioid epidemic by identifying novel therapeutic targets for treating opioid use disorder. Our preliminary studies have identified calcitonin gene-related peptide (CGRP) producing neurons in the parabrachial nucleus as potential direct activators of the negative affective states associated with opioid withdrawal. In this study, we seek to establish this functional connection and understand how opioid taking and protracted withdrawal result in gene expression and epigenetic changes within this neuronal population to evaluate the feasibility of leveraging CGRP therapeutics for treating opioid use disorder.

PI_NAMEs: BYSTROM, LAUREN L (contact)

PROGRAM_OFFICER_NAME: LIN, YU

PROJECT_TERMS: Abstinence;Address;Adrenergic Antagonists;Affect;Alcohol withdrawal syndrome;Amygdaloid structure;Anatomy;Automobile Driving;Behavior;Behavioral;Behavioral Paradigm;Bioinformatics;Brain region;Calcitonin Gene-Related Peptide;Cells;Chromatin;Chronic;Clinical Trials;Dangerousness;Data;differential expression;Disease;drug reward;Drug Targeting;Drug usage;drug withdrawal;Emotional;Epigenetic Process;epigenomics;experience;FDA approved;Gene Expression;Gene Expression Profile;Genes;Genetic;Glutamates;histone modification;Individual;inhibitor;interest;Intervention;Intravenous;lofexidine;long term abstinence;Maintenance;Maps;medication-assisted treatment;Migraine;migraine treatment;Modeling;Molecular;Molecular Profiling;Molecular Target;Morphine;Motivation;Mus;negative affect;Neurons;Neuropeptides;neurotransmission;new therapeutic target;non-opioid analgesic;novel;Nuclear;Opiate Addiction;Opioid;opioid epidemic;Opioid Receptor;opioid use disorder;opioid withdrawal;Pain;parabrachial nucleus;Patients;peptide drug;Peptide Signal Sequences;peripheral pain;Pharmaceutical Preparations;pharmacologic;Population;Positioning Attribute;Predisposition;Pruritus;Psychological reinforcement;Public Health;Recurrent disease;Relapse;relapse prevention;response;Role;Self Administration;Shapes;Stains;Substance abuse problem;Techniques;Testing;Therapeutic;therapeutically effective;Training;transcriptome;transcriptome sequencing;transcriptomics;transmission process;Withdrawal

PROJECT_TITLE: The Role of Parabrachial CGRP Neurons in Opioid Reinforcement

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F02A-W (20)]


NIH_SPENDING_CATS: Biotechnology;Chronic Pain;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Neurosciences;Pain Research

ORG_CITY: PITTSBURGH

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: CARNEGIE-MELLON UNIVERSITY

ORG_STATE: PA

PHR: Project Narrative In an effort to develop new tools to study pain in the spinal cord, as well as a new chronic pain treatment, I will first use statistical genetics to identify families of neurons in the spinal cord that have a genetic risk of malfunctioning and causing chronic pain. As a strategy to selectively activate or shut off these neuron families, I will then use machine learning to find, and design, DNA sequences, called cis-regulatory elements, which are predicted by my models to drive gene expression in just these neuron families, in order to block pain signaling without causing off-target effects. Finally, I will experimentally validate that these cis-regulatory elements indeed have specific activity in mouse, and collaborators will do the same in macaque; cis-regulatory elements discovered or designed in this project will serve as a useful resource for functional pain experiments in animals, and potentially for a novel therapeutic.

PI_NAMEs: LEONE, MICHAEL  (contact)

PROJECT_TERMS: Address;Affect;Analgesics;Anatomy;Animals;Anterior Horn Cells;Brain;causal variant;cell type;Cells;chronic pain;chronic pain management;clinical translation;Complex;Complex Genetic Trait;Data;Data Element;design;Development;Directed Molecular Evolution;Disease;Dissection;DNA Sequence;Dorsal;dorsal horn;Effectiveness;Enhancers;Epidemic;Esthesia;Experimental Animal Model;experimental study;Family;Future;Gene Activation;Gene Expression;gene therapy;Generations;Genes;Genetic;Genetic Markers;Genetic Risk;genetic variant;Genetic Variation;genome wide association study;Genomics;Goals;Horns;Human;Human Genetics;improved;In Situ;In Situ Hybridization;in vivo;Intervention;Laboratories;learning strategy;Linkage Disequilibrium;Lumbar spinal cord structure;Macaca;Machine Learning;machine learning model;machine learning pipeline;Manuals;Measures;mechanical allodynia;Mediating;Medical;Messenger RNA;Methods;Modeling;Molecular;Molecular Biology;Motor;Motor Neurons;mouse model;Mus;neural;neuronal excitability;Neurons;neuropsychiatric disorder;neuroregulation;Neurosciences;nonhuman primate;novel;novel therapeutics;Opioid;Overdose;Pain;Pain management;pain signal;Performance;Pharmacologic Substance;Physicians;Population;Posterior Horn Cells;Regulatory Element;Reproducibility;Research;Research Personnel;Resources;risk variant;Science;seal;Sensitivity and Specificity;side effect;single cell genomics;Specificity;Spinal Cord;Spinal cord posterior horn;Statistical Models;Target Populations;Techniques;Testing;Therapeutic;Tissues;tool;Training;Transgenes;Transgenic Mice;translational potential;transmission process;Validation;Work

PROJECT_TITLE: Identifying and targeting neural subpopulations of the spinal cord that mediate chronic pain via cell-type-specific cis-regulatory elements

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F08-L (20)]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Rare Diseases;Tuberculosis

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: PROJECT NARRATIVE Aerosolization, is an essential, yet poorly understood physiologic process, that is essential for the transmission and spread of Mycobacteria tuberculosis (Mtb), the causative agent of tuberculosis (TB) and the deadliest infectious disease worldwide. The goal of this proposal is to identify the specific genes and metabolic pathways that Mtb employs during its adaptive response to CO2 and nitrogen deprivation in the aerosol droplet environment. Identifying the key metabolic players during this adaptive response has the potential to reveal novel targets for therapeutics that block TB transmission and dramatically reduce its incidence and the global disease burden.

PI_NAMEs: NAZIA, SAKILA ZAMAN (contact)

PROGRAM_OFFICER_NAME: MENDEZ, SUSANA

PROJECT_TERMS: Abate;Address;aerosolized;Aerosols;Air;Ammonia;Anabolism;arginase;Arginine;Arginine deiminase;Atmosphere;Automobile Driving;Bacterial Infections;Bicarbonates;Biochemical;burden of illness;Carbamyl Phosphate;Carbon;Carbon Dioxide;carbonate dehydratase;Catalysis;Cause of Death;Citric Acid Cycle;Communicable Diseases;Consumption;cost;Coupled;Couples;Curiosities;Data;Decarboxylation;Defect;deprivation;Environment;Enzymes;Etiology;experience;Exposure to;Genes;Genetic;Goals;In Vitro;in vivo;Incidence;innovation;insight;Intervention;Kinetics;knock-down;Label;Life Cycle Stages;Lung;Measures;Mediating;Metabolic;Metabolic Pathway;Metabolism;Modeling;mortality;Mycobacterium tuberculosis;Natural regeneration;Nature;new therapeutic target;Nitrogen;novel;Nutrient;Nutrient availability;Ornithine;Outcome;pandemic disease;Pathway interactions;Physiological;Physiological Processes;preference;pressure;prevent;Process;Production;Proteins;Pyrimidine;Reaction;Recurrence;Recycling;response;Role;Source;Stress;Temperature;Testing;therapeutic target;Thermodynamics;transmission blocking;transmission process;Tricarboxylic Acids;Tuberculosis;Uracil;Urea

PROJECT_TITLE: Arginine Biosynthesis: A Metabolic Battery for Mycobacteria tuberculosis to Survive Aerosolization Stress

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F07A-B (20)]


NIH_SPENDING_CATS: Brain Disorders;Mental Health;Mental Illness;Neurosciences

ORG_CITY: BOSTON

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

ORG_STATE: MA

PHR: PROJECT NARRATIVE: Abnormal GABAergic inhibitory neurotransmission in the prefrontal cortex (PFC) is implicated in the cognitive and emotional disturbances present in schizophrenia and mood disorders, among the leading causes of disability globally. Using multi-tiered in vivo and in vitro functional, structural, and computational methods, this project aims to characterize the as yet unknown properties of dendritic inhibition and determine how they can shape cortical activity in functionally-distinct medial and lateral PFC areas in primates. This will shed vitally needed insight on the mechanisms of differential susceptibility of these PFC areas to network disruption, potentially aiding diagnosis via electrophysiological correlates of cognitive-affective disorders and improving pharmacological and neuromodulation-based interventions.

PI_NAMEs: SNYDER, BENJAMIN JAMES (contact)

PROGRAM_OFFICER_NAME: PINARD, COURTNEY ROSE

PROJECT_TERMS: 15 year old;Acute;Affect;Anesthesia procedures;Animal Model;Anterior;Apical;Area;Autopsy;Biophysics;Brain;calbindin;Calcium;calcium indicator;Calcium Signaling;Cells;cingulate cortex;Cognition Disorders;Cognitive;cognitive control;Computing Methodologies;confocal imaging;Confocal Microscopy;Coupling;Data;Dendrites;density;Diagnosis;disability;Dyes;Electrodes;Electrophysiology (science);Emotional Disturbance;executive function;Exhibits;experimental study;Frequencies;Functional disorder;Future;gamma-Aminobutyric Acid;Generations;Harvest;hippocampal pyramidal neuron;Human;Image;Immunohistochemistry;Impaired cognition;improved;In Vitro;in vivo;insight;Interneurons;Intervention;Kinetics;Label;Lateral;Macaca mulatta;Medial;Mediating;Mental Depression;Mental disorders;model organism;Monkeys;Mood Disorders;network models;neurochemistry;Neurons;neuropsychiatric disorder;neuroregulation;neurotransmission;Output;Parvalbumins;patch clamp;Pattern;pharmacologic;Physiological;Physiology;Play;Population;postsynaptic;Predisposition;Prefrontal Cortex;Primates;Process;Property;Propofol;Pyramidal Cells;receptor;Role;Schizophrenia;sex;Shapes;Signal Transduction;Slice;Somatostatin;Spatial Distribution;Synapses;Testing;Time;Tissues;Whole-Cell Recordings;Work;young adult

PROJECT_TITLE: Compartment-specific inhibition and laminar circuit dynamics in the primate prefrontal cortex.


NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Infectious Diseases;Microbiome

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: NARRATIVE Beginning with the eruption of baby teeth, dental caries affects humans of all races, ages, and sexes. The proposed studies will elucidate the novel catalytic mechanism(s) of glucosyltransferases by which the dental caries etiological agent Streptococcus mutans (SM) synthesizes insoluble (a-1,3-linked) and soluble (a-1,6- linked) glucans. The results will define novel enzymatic mechanism(s) and lead to the development of new inhibitors to prevent SM’s acid generation, which initiates enamel erosion and dental caries.

PI_NAMEs: DEIVANAYAGAM, CHAMPION CHRISTDOSS SELVAKUMAR (contact);WU, HUI

PROGRAM_OFFICER_NAME: MCNEALY, TAMARA L

PROJECT_TITLE: Structural and Functional Studies on the Glucosyltransferases of the Dental Caries Pathogen Streptococcus mutans

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MSOS-L (03)]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Antimicrobial Resistance;Clinical Research;Genetics;Health Services;Infectious Diseases;Malaria;Rare Diseases;Social Determinants of Health;Vector-Borne Diseases

ORG_CITY: CHAPEL HILL

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE Effective treatment is an essential component of malaria case management. In the Democratic Republic of the Congo (DRC), which accounts for 13% of all global malaria deaths, malaria control efforts are threatened by increasing reports of antimalarial drug resistance, including to artemisinin-based combination therapies, the current first-line and most effective treatment for Plasmodium falciparum. This proposal integrates genomic, epidemiological, and spatial approaches into a well-characterized 2015-2022 malaria longitudinal cohort study of children and adults to characterize the antimalarial drug resistance landscape in Kinshasa, the most populous province in the DRC.

PI_NAMEs: FRANCOIS, RUTHLY  (contact)

PROGRAM_OFFICER_NAME: RAO, MALLA R

PROJECT_TERMS: Address;Adult;Africa South of the Sahara;Age;Alleles;Amodiaquine;Anti-malarial drug resistance;Anti-malarials;Area;artemether;Artemisinins;artesunate;Bayesian Modeling;benflumetol;biomarker validation;Case Management;Cessation of life;Child;Clinical Data;clinical training;cohort;Collaborations;Combination Drug Therapy;Combined Modality Therapy;Communicable Diseases;Communities;community setting;cost effective;Country;Cross-Sectional Studies;Data;data integration;deep sequencing;Democratic Republic of the Congo;Diagnostic tests;Drug resistance;drug resistance development;Drug usage;effective therapy;Eligibility Determination;Epidemiologic Methods;Epidemiology;Fellowship;Funding;Future;Genes;Genetic Markers;Genomics;Geography;global health;Goals;Health care facility;improved;Individual;Institution;Interdisciplinary Study;International;lens;Longitudinal cohort study;Longitudinal Studies;Malaria;matriculation;Measures;Medicine;Modification;Molecular;Molecular Epidemiology;molecular marker;Morbidity - disease rate;mortality;Mutation;North Carolina;overtreatment;Parasites;Patient Self-Report;peri-urban;Pharmaceutical Preparations;Physicians;Plasmodium falciparum;Policies;Population;Pregnancy;preservation;pressure;Prevalence;Preventive therapy;Probability;Province;Proxy;Publishing;Pyrimethamine;Rapid diagnostics;Reaction;Reporting;Research;Research Proposals;residence;Residencies;Resistance;Role;Rural;Rwanda;Sampling;Scientist;Selection Bias;Severity of illness;Site;skills;spatial epidemiology;spatiotemporal;Statistical Methods;Sulfadoxine;Sulfadoxine-pyrimethamine resistance;Surveys;Tanzania;Test Result;Time;Training;treatment effect;treatment guidelines;Uganda;United States National Institutes of Health;Universities;Visit;Weight;Work

PROJECT_TITLE: Characterization of the antimalarial drug resistance landscape in Kinshasa Province, Democratic Republic of the Congo

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F18-E (20)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Neurosciences;Psychosis;Schizophrenia;Serious Mental Illness

ORG_CITY: NEW YORK

PHR: PROJECT NARRATIVE Hallucinations and other psychotic symptoms of schizophrenia are highly burdensome conditions for patients and society at large, and treatments for these symptoms are often ineffective or poorly tolerated. A necessary first step towards developing more selective biological interventions is to elucidate mechanisms of these symptoms at a neurobiological circuit level. Here, we test the predictions of a computational model of corticostriatal circuitry using translational experiments in humans and mice to clarify the circuit neurobiology of hallucinations.

PI_NAMEs: HORGA, GUILLERMO  (contact);IIGAYA, KIYOHITO ;KELLENDONK, CHRISTOPH

PROGRAM_OFFICER_NAME: WIJTENBURG, SARAH ANDREA

PROJECT_TERMS: Address;Algorithms;Anatomy;Antipsychotic Agents;Auditory;Auditory Hallucination;Behavior;Behavioral;behavioral phenotyping;Biological;cholinergic;Clinical;clinical investigation;Clinical Research;Cognitive;cohort;Computer Models;Computing Methodologies;Corpus striatum structure;Data;design;Detection;Dopamine;dopaminergic neuron;Dorsal;Electrophysiology (science);Elements;expectation;Experimental Designs;experimental study;Functional Magnetic Resonance Imaging;Generations;Genetic;Genetic Risk;Hallucinations;Human;human data;improved;in vivo;indexing;Interneurons;Intervention;Investigation;Knowledge;Learning;Magnetic Resonance Imaging;Measures;Mediating;Methods;Modeling;mouse model;multidisciplinary;Mus;Nature;neural;Neurobiology;neurochemistry;neuromelanin;Neurons;novel;optogenetics;Pathway interactions;Patients;Perception;Perceptual learning;Phenotype;Play;Population;pre-clinical;pre-clinical research;Probability;Process;Psychoses;psychotic;psychotic symptoms;Reporting;Rewards;Role;Schizophrenia;schizophrenia risk;Science;sensor;Sensory;severe mental illness;Severities;Signal Transduction;Societies;sound;Speed;Stimulus;Substantia nigra structure;symptom treatment;Symptoms;System;Testing;theories;translational study;Uncertainty;Ventral Striatum;Work

PROJECT_TITLE: Translational studies in humans and mice to test a circuit-level computational model of auditory hallucinations..

STUDY_SECTION: PMDA

STUDY_SECTION_NAME: Pathophysiological Basis of Mental Disorders and Addictions Study Section[PMDA]


ADMINISTERING_IC: NR

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Services;Hematology;Infectious Diseases;Patient Safety;Prevention;Sepsis

ORG_CITY: PHILADELPHIA

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE. Many sepsis survivors are not educated on their diagnosis nor its implications for self-care after hospital discharge, leading to knowledge deficits that consequentially contribute to delayed follow-up care, poor health outcomes, and frequent rehospitalizations. The Surviving Sepsis Campaign calls for nurses and other clinicians to deliver patient education tailored to the specific needs of sepsis survivors; yet, research on sepsis patient education interventions is limited. By measuring the relationship of sepsis patient education quality as perceived by sepsis survivors to education and health outcome indicators, this study will inform future patient education interventions dedicated to reducing knowledge deficits and improving health outcomes among sepsis survivors.

PI_NAMEs: SANG, ELAINE  (contact)

PROGRAM_OFFICER_NAME: HUSS, KAREN

PROJECT_TERMS: Address;advanced disease;Advocate;care systems;Caring;Chronic;Chronic Disease;Chronically Ill;Clinical;comorbidity;Data Collection;Dedications;Dementia;Development;Diagnosis;Early Intervention;Education;Educational Intervention;Effectiveness;empowerment;experience;Fatigue;Fellowship;follow-up;Foundations;Future;Health;health equity;health literacy;Health Promotion;hospice environment;hospital readmission;Hospitalization;Hospitals;improved;Infection;Infection prevention;Inpatients;insight;Intensive Care;Intervention;Knowledge;Lead;lens;low health literacy;Malignant Neoplasms;Managed Care;Measures;Medical;Mentorship;Methodology;Mission;Modeling;Monitor;Morbidity - disease rate;Nurse's Role;Nurses;Nursing Research;Operative Surgical Procedures;Outcome;Pain;Patient Education;Patients;Pennsylvania;Perception;Policies;poor health outcome;Population;prevent;Prevention;programs;Qualifying;readmission rates;Recurrence;Reporting;Research;Self Care;Self Efficacy;Sepsis;Sepsis Syndrome;septic patients;skills;Strategic Planning;Survivors;Symptoms;System;Testing;Time;Training;training opportunity;Universities;Visiting Nurse

PROJECT_TITLE: Sepsis Patient Education: Perspectives from Home Health Nurses and Knowledge among Sepsis Survivors

STUDY_SECTION: NRRC

STUDY_SECTION_NAME: National Institute of Nursing Research Initial Review Group[NRRC (88)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Circuit mechanisms of reward-context learning, involved in complex exploration behaviors, remain unclear despite increasing health challenges in substance abuse and other mental disorders (e.g., attention disorders and cognitive decline). I propose to examine the role of rewards and reward expectation in exploration and memory formation using electrophysiology, intracranial stimulation, and animal pose tracking methods. Insights into how reward circuits and memory systems (e.g., the hippocampus) interact to form neural codes are critical for understanding complex behaviors and developing therapeutic interventions.

PI_NAMEs: OZEL, PELIN  (contact)

PROJECT_TERMS: Affect;Anatomy;Animal Testing;Animals;Attention;Behavior;career development;Cells;Chemosensitization;Code;Collaborations;Communication;Communities;Complex;Data Analyses;Disease;dopaminergic neuron;Electric Stimulation;Electrodes;Electrophysiology (science);Environment;Episodic memory;Excision;expectation;experience;Fellowship;Fire - disasters;flexibility;Food;Future;Goals;Head;Health;Hippocampal Formation;Hippocampus;Impaired cognition;in vivo;information gathering;insight;Learning;Location;Mammals;median forebrain bundle;member;Memory;memory encoding;Mental disorders;Methods;Mission;National Institute of Mental Health;neural;Neurons;novel;Nucleus Accumbens;place fields;Population;Pyramidal Cells;Rattus;Research;Resources;Rewards;Role;Running;Scanning;Science;Silicon;Site;spatial memory;spatiotemporal;Statistical Data Interpretation;Statistical Methods;Substance abuse problem;System;Testing;theories;Therapeutic;Therapeutic Intervention;Time;Training;Universities;Ventral Tegmental Area;Water;Work

PROJECT_TITLE: Head Scanning Behavior and Reward Interactions in Potentiation of Place Fields


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Digestive Diseases;Genetics;Immunotherapy;Pancreatic Cancer;Rare Diseases

ORG_CITY: ANN ARBOR

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: Project Narrative An immunosuppressive tumor microenvironment (TME) in pancreatic cancer, one of the deadliest human malignancies, is known to be a major barrier to effective treatment. We propose to study how cellular interaction within the pancreatic TME through CCR1-IRG1 axis contributes to pancreatic carcinogenesis and explore the therapeutic potential of targeting IRG1, using both mouse models and patient derived organoids. Our study will not only provide critical insights into the immune suppressive function of CCR1-IRG1 axis in pancreatic cancer, thereby addressing a significant knowledge gap in the field, but also identify novel therapeutic approaches to effectively treating pancreatic cancer.

PI_NAMEs: ZHANG, YAQING  (contact);ZHENG, BIN

PROGRAM_OFFICER_NAME: KAI, MIHOKO

PROJECT_TERMS: Ablation;Address;Allografting;Anabolism;Animal Cancer Model;anti-PD-1;anti-PD1 therapy;Aspartate;Autologous;Bone Marrow;cancer cell;carcinogenesis;CCR1 gene;CD8-Positive T-Lymphocytes;Cells;Cellular biology;chemokine receptor;Citric Acid Cycle;Coculture Techniques;Computational Biology;Cytometry;Data;Data Set;Disease Progression;effective therapy;Enzymes;Fibroblasts;Genes;genetic approach;Genetically Engineered Mouse;Glycine;Goals;Growth;Heterogeneity;Human;Human Pathology;Immune;immune checkpoint blockade;Immune Targeting;Immunology;immunoregulation;Immunosuppression;Immunotherapy;In Vitro;Inflammatory;inhibitor;insight;Knowledge;KRAS oncogenesis;KRAS2 gene;KRASG12D;Laboratories;Lead;Lesion;Macrophage;Malignant neoplasm of lung;Malignant neoplasm of pancreas;Malignant Neoplasms;Mediating;Melanoma;Metabolic;mouse model;Mus;Myelogenous;Myeloid Cells;Myeloid-derived suppressor cells;neoplastic cell;novel;novel therapeutic intervention;Oncogenic;Organoids;Pancreas;pancreas development;Pancreatectomy;pancreatic cancer patients;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma model;pancreatic neoplasm;pancreatic tumorigenesis;Pathway interactions;Patients;pharmacologic;Phenotype;Production;Proliferating;recruit;Regulation;Reporting;Research Personnel;Role;Sampling;Scheme;Serine;Signal Pathway;Signal Transduction;single-cell RNA sequencing;small molecule inhibitor;Survival Rate;synergism;T cell infiltration;T-Lymphocyte;Testing;Therapeutic;therapeutically effective;transcriptomics;tumor;tumor growth;Tumor Immunity;tumor microenvironment;Tumor-associated macrophages;tumor-immune system interactions

PROJECT_TITLE: Metabolic regulation of immunosuppressive myeloid cells in the tumor microenvironment of pancreatic cancer.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BTC-Q (80)]


NIH_SPENDING_CATS: Obesity

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Project Narrative Primary cilia are signaling organelles present on nearly all stem and progenitor cells throughout the body that regulate cell fate, including the differentiation of preadipocytes into mature, fat storing adipocytes through adipogenesis. It is unclear how the cilium regulates this process, though recent discoveries highlight the only described ciliary G protein-coupled receptor drives adipogenesis in a cilia-dependent manner by increasing ciliary cAMP. This proposal will investigate the necessity and sufficiency of ciliary cAMP in the adipogenic process, as well as identify additional adipogenesis-modulating G protein-coupled receptors that localize to the preadipocyte cilium.

PI_NAMEs: LEE, MARK DAVID (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Academia;Adenylate Cyclase;adipocyte differentiation;Adipocytes;Adipose tissue;Biosensor;Carbohydrates;career;cell type;Cells;Cilia;combat;Complex;Coupled;Cyclic AMP;Data;designer receptors exclusively activated by designer drugs;Development;Diffuse;Dinoprostone;Environment;EP4 receptor;Equilibrium;extracellular;Fatty acid glycerol esters;Fibrosis;Flow Cytometry;Fostering;Future;G Protein-Coupled Receptor Signaling;G-Protein-Coupled Receptors;Genetic;Genetic Engineering;Genetic Transcription;Goals;Growth;GTP-Binding Protein alpha Subunits, Gs;Health;Hypertrophy;Immunofluorescence Immunologic;In Vitro;in vivo;Insulin;Investigation;Knock-out;Laboratories;Ligands;Link;lipid biosynthesis;Mass Spectrum Analysis;Measures;Mentors;Mentorship;Metabolic;Metabolic Diseases;metabolomics;Microscopy;Molecular;Mus;Mutation;Nature;Non-Insulin-Dependent Diabetes Mellitus;Nonesterified Fatty Acids;Obesity;Obesity Epidemic;Organelles;Phosphodiesterase Inhibitors;Physiological;Prevalence;Process;Production;Proteins;receptor;Regulation;Reporter;Research;Research Personnel;response;Role;sensor;Services;Signal Transduction;Specificity;Stains;stem;stem cells;synthetic drug;teacher;Technical Expertise;Testing;Therapeutic Intervention;Tissue Expansion;tool;trafficking;Training;Training Programs;Training Support;transcriptomics;Universities;Utah;western diet;WFDC2 gene;Work

PROJECT_TITLE: Investigation of the preadipocyte primary cilia signalosome


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cardiovascular;Clinical Research;Dementia;Genetics;Neurodegenerative;Neurosciences;Pediatric;Physical Activity;Prevention

ORG_CITY: OMAHA

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: Project Narrative Alzheimer’s Disease (AD) is typically considered a disease of older adulthood, however the influence of modifiable and non-modifiable risk factors, beginning in childhood, significantly influence AD development later in life. Through a novel, multimodal approach, we aim to collect data related to brain development (cognitive, brain imaging), modifiable risk factors (physical activity, cardiorespiratory fitness) and non-modifiable risk factors (APOE-ε4 allele status) in order to understand early-life vulnerabilities that effect AD risk. Characterizing the development of AD-vulnerable brain systems, and how these risk factors influence them, could lead to new insights regarding early-life risk stratification and disease prevention.

PI_NAMEs: HELLER-WIGHT, ABI  (contact)

PROGRAM_OFFICER_NAME: SARE, RACHEL

PROJECT_TERMS: 13 year old;Accelerometer;Affect;Age;aged;aging related disease;Alleles;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease risk;apolipoprotein E-4;Area;Birth;Brain;Brain imaging;brain magnetic resonance imaging;cardiorespiratory fitness;Child;Childhood;Clinical;clinical training;Cognition;Cognitive;cognitive ability;cognitive benefits;cognitive development;cognitive neuroscience;cognitive process;cognitive testing;cohort;critical period;Cross-Sectional Studies;Data;Data Analyses;Development;Dimensions;Disease;Disease susceptibility;disorder prevention;DNA;doctoral student;early adolescence;Educational workshop;Enrollment;executive function;Exercise;experience;Fellowship;fitness test;Functional Magnetic Resonance Imaging;Generations;Genes;Genetic;Genetic Risk;Genotype;Health Policy;high risk;human old age (65+);Human Subject Research;Impaired cognition;Individual;insight;Investigation;Knowledge;late life;Late Onset Alzheimer Disease;Life;life span;Link;Measures;Mediating;Medical center;Memory;memory process;middle childhood;modifiable lifestyle factors;modifiable risk;Monitor;multimodality;Nebraska;neurodevelopment;neurodevelopmental effect;Neuronal Plasticity;neurotrophic factor;novel;older adult;parent project;Parents;Participant;participant enrollment;Pathology;Patient Self-Report;Performance;periadolescent;Persons;Physical activity;Physical Fitness;Physicians;Population;Preceptorship;Prevalence;preventive intervention;protective effect;Public Health;relational memory;Research;Research Design;Research Methodology;Research Training;Rest;Risk Factors;risk mitigation;risk stratification;risk variant;Science;Scientist;skills;Sorting;Standardization;System;Task Performances;Testing;United States National Institutes of Health;Universities;Visit;Writing

PROJECT_TITLE: Measuring neurodevelopmental effects of genetic risk for Alzheimer's disease via cross-sectional study of brain, cognitive, and physical fitness variables in periadolescent children

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F01A-V (20)]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Data Science;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: La Jolla

ORG_NAME: SALK INSTITUTE FOR BIOLOGICAL STUDIES

PHR: PROJECT NARRATIVE A majority of disease-associated genetic variants are located within the non coding region of the genome where the genetic regulatory code is poorly understood. To help inform us which variant is causal for a phenotypic disease of interest, it is imperative to learn the variant to function characterization of genetic variants to decipher the non coding regulatory code. This proposal will develop a novel deep learning model that can predict genetic variants impact on chromatin accessibility, which we use as a proxy for variant function.

PI_NAMEs: JAUREGUY, JEFF  (contact)

PROGRAM_OFFICER_NAME: FUFA, TEMESGEN D

PROJECT_TERMS: Affect;aggregation database;Alleles;Allelic Imbalance;Aptitude;ATAC-seq;Awareness;base;Biological Assay;causal variant;cell type;Chromatin;Clustered Regularly Interspaced Short Palindromic Repeats;Code;Communication;Complex;Coupled;CRISPR/Cas technology;Data;Data Set;deep learning;deep learning model;Disease;disease phenotype;DNA Binding;DNA Sequence;Educational process of instructing;Etiology;Evaluation;experience;experimental study;Fellowship;Frequencies;Gene Expression;Genes;Genetic;genetic association;genetic predictors;Genetic Research;genetic variant;Genetic Variation;Genome;genome editing;genome wide association study;Genomics;Genotype;Goals;Haplotypes;Heterozygote;Human;Human Genetics;human induced pluripotent stem cells;improved;Individual;interest;Investigation;Knowledge;Laboratories;Learning;Linkage Disequilibrium;Machine Learning;machine learning method;machine learning model;machine learning prediction;Maps;Measurement;Mentors;Methods;Modeling;Molecular;neural network;novel;Outcome;Output;Performance;personalized medicine;Phase;Population;Postdoctoral Fellow;predictive modeling;Proxy;Publishing;Quantitative Trait Loci;rare variant;reference genome;repaired;Research;Research Personnel;Research Proposals;Site;skills;success;tool;Training;trait;transcription factor;Universities;Untranslated RNA;Validation;Variant;Writing

PROJECT_TITLE: Predicting the effects of genetic variants on chromatin accessibility with a deep learning approach


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Maternal Health;Mental Health;Neurosciences;Pediatric;Women's Health Research

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: PROJECT NARRATIVE  Crying is the only way infants can communicate their needs – unfortunately, maladaptive responses to infant sounds have been associated with neurological and hormonal pathologies impacting motherhood, such as those that lead to postpartum depression. Disentangling the neural circuitry that supports adaptive maternal responses is essential for supporting infant well-being and maternal mental health outcomes. In this proposal, I will take advantage of cutting-edge whole-brain imaging and genetic tools available in mice to uncover the brain- wide neural mechanisms that enhance the maternal response to auditory cues from their offspring, with the potential of identifying ways we can predict and intervene in cases where these responses may go awry.

PI_NAMEs: MCRAE, BRIANA ROSE (contact)

PROGRAM_OFFICER_NAME: MILLER, BRETT

PROJECT_TERMS: Ablation;Address;Affect;Amygdaloid structure;Animal Experimentation;Animals;Area;Auditory;Auditory area;awake;Behavior;behavioral response;Biological Assay;Birth;Brain;Brain imaging;Brain region;caregiving;Caring;Cell Nucleus;Child;Child Welfare;Communication;Crying;Cues;Development;Distress;Exhibits;experience;Female;Functional Magnetic Resonance Imaging;Genetic;genetic approach;genetic manipulation;Hormonal;Human;Hypothalamic structure;imaging approach;Immediate-Early Genes;Infant;infant outcome;Knock-out;learned behavior;Learning;Left;Link;Maps;Maternal Behavior;Measures;Mediating;Mental Health;Methods;Modeling;motherhood;Mothers;Motivation;Mus;Mutation;neural;neural circuit;Neurologic;neuromechanism;Neurons;Neuropeptides;neuroregulation;novel;offspring;Outcome;Oxytocin;Oxytocin Receptor;Pathology;Personal Satisfaction;Postpartum Depression;Process;pup;Reporting;Research;response;Risk;Role;Signal Transduction;sound;Stimulus;Surveys;targeted treatment;Techniques;Therapeutic;Time;tool;vocalization;Work

PROJECT_TITLE: Brain-wide neural mechanisms enhancing maternal behavioral response to infant cues


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Digestive Diseases;Genetics;Human Genome;Pancreatic Cancer;Rare Diseases

PHR: PROJECT NARRATIVE The classical subtype of PDAC expresses lineage specifying transcription factors that are important in normal development and cell fate determination. Although cell identity is tightly regulated by TFs, the transcriptional network that governs the classical subtype of PDAC has yet to be clearly defined and how these networks are redefined due to targeted therapies is unknown. This proposal aims to define the transcriptional networks created by lineage specifying transcription factors and how modulating oncogenic signaling alter these networks.

PI_NAMEs: ORELLANA, WALTER ALEXANDER (contact)

PROGRAM_OFFICER_NAME: ADAMS, GREGORY

PROJECT_TERMS: Appendix Adenocarcinoma;Beta Cell;Biological Markers;cancer cell;Cancer Etiology;Cell Line;Cell Physiology;Cells;Cessation of life;chemotherapy;ChIP-seq;Classification;clinical subtypes;clinically relevant;clinically significant;Data;Development;Disease;Epithelium;Exhibits;Gastrointestinal tract structure;Gene Expression;Gene Targeting;Genes;Genetic Transcription;Genomics;Growth;HNF4A gene;Homeostasis;Human;improved;insight;Intention;KRAS2 gene;Lead;Light;Liver;Malignant neoplasm of lung;Malignant Neoplasms;Measures;MEKs;Metabolism;Molecular;Morphogenesis;Mus;Mutation;Neoplasm Metastasis;neoplastic;Nuclear Receptors;Oncogenic;Organoids;Pancreas;pancreas development;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;Pathway interactions;Patient-Focused Outcomes;Play;programs;Proteomics;Publishing;reconstitution;Regulation;resistance mechanism;response;restraint;RNA;Role;Signal Transduction;Specific qualifier value;Survival Rate;targeted treatment;Testing;Therapeutic;Tissues;transcription factor;transcriptome sequencing;transcriptomics;Tumor Suppressor Genes;Work

PROJECT_TITLE: Investigating the role of FOXA1/2 and HNF4⍺ in Pancreatic ductal adenocarcinoma

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F09A-R (20)]


NIH_SPENDING_CATS: Brain Disorders;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Methamphetamine;Neurodegenerative;Neurosciences;Opioids;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: CLEVELAND

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative Poly-substance use (METH, opioids) has been shown to enhance neuronal damage and dramatically increase the risk of HIV-associated neurocognitive disorders (HAND), creating a significant unmet medical challenge. Here we will use ex vivo models derived from induced pluripotent stem cells (iPSC) to determine whether silent HIV infections in the brain become reactivated in response to poly-substance exposure and dissect the intracellular signals responsible for HIV reactivation.

PI_NAMEs: KARN, JONATHAN  (contact)

PROGRAM_OFFICER_NAME: WU, DA-YU

PROJECT_TERMS: Acute;Adenosine;Affect;Agonist;Anti-Inflammatory Agents;Antibodies;antiretroviral therapy;Astrocytes;Autologous;Autopsy;Bioinformatics;Brain;CD 200;Cell model;Cells;Central Nervous System;Cerebrum;Chronic;Clinic;Coculture Techniques;Collaborations;CRISPR/Cas technology;cytokine;design;DNA;dopaminergic neuron;DRD1 gene;Environment;experience;experimental study;extracellular;Fentanyl;Flow Cytometry;Gene Expression;Glucocorticoids;Goals;HIV;HIV Infections;HIV-associated neurocognitive disorder;Human;Immunofluorescence Immunologic;Induced Neurons;induced pluripotent stem cell;Induced pluripotent stem cell derived neurons;Inflammatory;innovation;Investigation;knockout gene;Measures;Medical;Membrane Proteins;Metabolic;Metabolism;meter;Methamphetamine;methamphetamine effect;Methods;Microglia;Modeling;Molecular;Monitor;mu opioid receptors;multidisciplinary;National Institute of Drug Abuse;Nervous System Disorder;Neurological Models;Neurons;neurotoxicity;Neurovirology;Opioid;Organoids;Oxidative Stress;Oxycodone;Paracrine Communication;Persons;Phagocytosis;Pharmaceutical Preparations;Pharmacotherapy;Physiological;Physiology;Poly I-C;polysubstance use;Prevalence;Protein Analysis;receptor;Regimen;Regulation;response;Risk;RNA;Sampling;Signal Transduction;single-cell RNA sequencing;Stimulus;Study models;substance use;Surface;System;Testing;Time;TNF gene;Transcriptional Regulation;transcriptomics;Treatment Protocols;Uncertainty;Virus;Virus Latency;Work

PROJECT_TITLE: The impact of poly-substance use on the crosstalk between microglia, astrocytes, and neurons that regulates HIV latency

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 GXM-N (J1)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Mental Health;Methamphetamine;Neurosciences;Sleep Research;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: JACKSON

ORG_NAME: UNIVERSITY OF MISSISSIPPI MED CTR

ORG_STATE: MS

PHR: Project Narrative Over the last several years, the use of methamphetamine has increased markedly in the United States. Patients seeking treatment for methamphetamine use disorder describe experiencing cognitive deficits and, notably, also report an increased incidence of sleep disturbances, which also can lead to cognitive deficits independent of methamphetamine use. Addressing cognitive problems associated with methamphetamine-induced sleep disruptions may offer a novel treatment strategy to improving patient outcomes, including reducing the risk of relapse.

PI_NAMEs: BORGATTI, DANIEL  (contact)

PROGRAM_OFFICER_NAME: FALCON-MORALES, EDGARDO

PROJECT_TERMS: Abstinence;actigraphy;Acute;addiction;Address;Animal Model;antagonist;Behavior Therapy;Biological Models;Chronic;Cognition;Cognitive;Cognitive deficits;cognitive function;cognitive testing;Cognitive Therapy;Data;Dimensions;Dose;Drug usage;executive function;experience;experimental study;Female;Food;Goals;Human;hypocretin;Impaired cognition;Impairment;improved;improvement on sleep;Incidence;Individual;Literature;Macaca mulatta;male;Measures;Mediating;Methamphetamine;methamphetamine abuse;methamphetamine effect;methamphetamine exposure;methamphetamine use;Methamphetamine use disorder;methamphetamine user;Modeling;Monitor;Monkeys;Neuropsychological Tests;novel;novel strategies;novel therapeutic intervention;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;pharmacologic;Play;poor sleep;preclinical study;prevent;Procedures;Relapse;relapse risk;Reporting;Research;Risk Reduction;Role;Sampling;Self Administration;Short-Term Memory;Sleep;Sleep Disorders;Sleep disturbances;sleep quality;Substance Use Disorder;Testing;Time;Training;Translating;Treatment outcome;treatment strategy;United States

PROJECT_TITLE: Role of sleep disruption in cognitive impairment associated with methamphetamine use


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences

ORG_DEPT: PSYCHOLOGY

PHR: Project Narrative The representational quality of episodic memory is diminished in older adulthood, but little is known about the neurocognitive mechanisms that underlie age-related declines in memory specificity nor individual variations in these declines. The proposed project aims to leverage scalp electrophysiological recordings and computational modeling at the individual-subject level as non-cognitively impaired young and older adults complete mnemonic similarity recognition tasks. These methods will enable us to investigate the neural corrrelates and cognitive processes that underlie variations in the representational quality of episodic memories within and across young and older adults, paving the way for future non-invasive methods of measuring memory quality and predicting memory loss associated with aging and neurocognitive diseases.

PI_NAMEs: GREENE, NATHANIEL ROBERT (contact)

PROGRAM_OFFICER_NAME: WAGSTER, MOLLY V

PROJECT_TERMS: Accounting;age acceleration;age difference;age group;age related;age related decline;Aging;aging population;Behavioral;behavioral study;candidate identification;career;Cognitive;cognitive process;combat;Computer Models;Cross-Sectional Studies;Data;design;Development;Disease;Disease Progression;Electrophysiology (science);Episodic memory;experience;experimental study;forgetting;Functional Magnetic Resonance Imaging;Future;Goals;Grant;Health;healthy aging;high dimensionality;Impaired cognition;Impairment;Individual;Individual Differences;individual variation;insight;Intervention;Investigation;Knowledge;Link;machine learning classifier;Measures;member;Memory;Memory Loss;Mentors;Methods;Modeling;neural;neural patterning;Neurocognitive;neurocognitive disorder;neuroimaging;neuromechanism;noninvasive diagnosis;novel;older adult;Outcome;Participant;Performance;predictive tools;Predisposition;prevent;Process;programs;recruit;Research;Retrieval;Risk;Scalp structure;skills;Source;Specificity;Task Performances;Techniques;Training;United States;Variant;Writing;young adult

PROJECT_TITLE: An Investigation of the Neurocognitive Mechanisms of Age-Related Declines in Episodic Memory Representational Specificity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F01B-M (20)]


NIH_SPENDING_CATS: Aging;Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Cannabinoid Research;Cardiovascular;Clinical Research;Prevention;Substance Misuse

ORG_CITY: PISCATAWAY

ORG_DEPT: MISCELLANEOUS

ORG_NAME: RUTGERS, THE STATE UNIV OF N.J.

ORG_STATE: NJ

PHR: PROJECT NARRATIVE Vascular dysfunction, such as hypertension or atherosclerosis, is a leading cause of death in the United States and linked to heavy drinking behaviors. However, the acute effects of alcohol on vascular functioning are subtle and clouded by chronic cardiovascular loads such as frequent heavy drinking, drug-drug interactions (such as alcohol/cannabis co-use), and chronic stress. This application proposes five training goals and three research aims to launch a unique line of independent research that seeks early signs of vascular dysfunction to reduce alcohol-related cardiovascular disease prevalence.

PI_NAMEs: MUZUMDAR, NEEL  (contact)

PROGRAM_OFFICER_NAME: LIN, LI

PROJECT_TERMS: Acute;Adult;Affect;Alcohol consumption;alcohol effect;alcohol response;alcohol use disorder;Alcoholic beverage heavy drinker;Alcoholic Intoxication;Alcohols;allostasis;allostatic load;Atherosclerosis;Behavior;Beverages;binge drinking;Biological Assay;Blood;Blood alcohol level measurement;Blood flow;Blood Pressure;Blood Pressure Monitors;Blood Vessels;Body System;Cannabis;Cardiovascular Diseases;cardiovascular effects;Cardiovascular Physiology;Cardiovascular system;Career Choice;career networking;Cause of Death;Characteristics;Chronic;chronic alcohol ingestion;Chronic stress;college;Conscious;Coronary Arteriosclerosis;design;Detection;Deterioration;Development;Diagnosis;Disease;Dose;drinking;drinking behavior;Drug Interactions;early detection biomarkers;Early Diagnosis;Early identification;Electrocardiogram;emerging adult;endogenous cannabinoid system;experimental study;Fatigue;Fellowship;fighting;flexibility;Foundations;Future;Goals;grasp;Guidelines;Health;Health behavior;Heavy Drinking;Homeostasis;Hypertension;Individual;Individual Differences;Intoxication;Isometric Exercise;Laws;Life;life span;lifestyle factors;Limb structure;Link;Low Prevalence;marijuana use;marijuana user;Measures;middle age;Modeling;National Institute on Alcohol Abuse and Alcoholism;National Research Service Awards;novel;Periodicals;Persons;Pharmaceutical Preparations;Pharmacodynamics;pharmacologic;physical conditioning;Physiological;Placebos;polysubstance use;Positioning Attribute;pressure;Prevalence;primary outcome;Process;Property;Public Health;Randomized;Recovery;Recreation;recruit;Reporting;Research;Research Design;research study;Residual state;response;Risk;Series;Solid;Stress;stressor;substance misuse;substance use;Symptoms;synergism;System;teaching assistant;Testing;Tetrahydrocannabinol;Time;Training;United States;Upper Extremity;urinary;Vascular Diseases;vascular injury;vasoconstriction;Vasodilation;Work;young adult

PROJECT_TITLE: Vascular Reactivity to Compounding Stressors across the Blood Alcohol Curve: Interactions with Chronic Drinking and Polysubstance Use

STUDY_SECTION_NAME: Special Emphasis Panel[ZAA1 GG (32)]


NIH_SPENDING_CATS: Genetics;Neurosciences

ORG_NAME: COLUMBIA UNIV NEW YORK MORNINGSIDE

PHR: Project Narrative UNC-6/Netrin plays vital roles in the directing of neuronal axons to their target cells, as well as in the formation of synapses, the connections between neurons that permit communication between them. It is unknown, though, whether the neurons that express unc-6/Netrin for the purpose of axon pathfinding are the same as those that express unc-6/Netrin to facilitate synapse formation. I propose to use the roundworm C. elegans to determine whether these two functions are separable and to characterize neuron-specific control of unc-6/Netrin expression, which may help me to elucidate the relative contribution of the lack of each of these functions in unc-6/Netrin-associated neurodevelopmental diseases.

PI_NAMEs: RUMLEY, JONATHAN DOUGLAS (contact)

PROGRAM_OFFICER_NAME: VAN'T VEER, ASHLEE VICTORIA

PROJECT_TERMS: Adult;Alleles;Animal Model;Animals;Axon;axon guidance;axonal pathfinding;Binding Sites;Biological Models;Caenorhabditis elegans;cell type;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Collection;Color;Communication;CRISPR/Cas technology;Cues;Embryo;Environment;Event;Excision;experimental study;Generations;Genes;Genome engineering;Goals;Hermaphroditism;Human;improved;Individual;Institution;Introns;Label;Ligands;Link;Location;Logic;Maintenance;Mediating;Mentorship;mutant;Nematoda;Nerve;Neurites;Neurodevelopmental Disorder;neurogenetics;Neuroglia;neuronal circuitry;Neurons;Neurosciences;novel strategies;Nucleic Acid Regulatory Sequences;oral communication;Pattern;Phenotype;Play;post-doctoral training;Reagent;receptor;Regulation;Regulatory Element;Reporter;Reporting;Research;Research Personnel;Review Literature;Role;selective expression;Signal Transduction;single-cell RNA sequencing;skills;Source;Synapses;synaptogenesis;System;Testing;Training;transcription factor;transcription factor USF;Transcription Initiation Site;Transgenes;Universities;Untranslated RNA;Vertebrates;Visualization;Work;Writing

PROJECT_TITLE: Dissecting regulation and function of unc-6/Netrin via the generation of cis-regulatory alleles

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-P (02)]