ORG_DEPT: BIOCHEMISTRY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Relevance to Public Health: Genome rewiring events, through translocations, deletions, and even massive chromosomal rearrangements, contribute to genome instability associated with many human diseases, including a significant portion of cancers and inherited or spontaneous diseases. Furthermore, many classes of noncoding RNAs participate in genome remodeling pathways or the maintenance of genome integrity, and their loss or dysfunction can increase the frequency of genome rearrangements, resulting in either deletion of tumor-suppressing genes, formation of chimeric genes, or over-expression of genes that promote tumor stability. The extreme degree of natural genome editing events in Oxytricha make it unparalleled as a model system to study genome stability, and similar mechanisms that may contribute to genome instability and cancer in humans.

PI_NAMEs: LANDWEBER, LAURA F (contact)

PROJECT_TERMS: Address;Adenine;Architecture;Biochemistry;Biological Models;Biology;chimeric gene;Chromatin;Chromosomal Rearrangement;comparative genomics;Complex;Crying;Development;Disease;DNA;Eukaryota;Event;Evolution;Frequencies;Functional disorder;Gene Expression;Gene Rearrangement;Genes;Genetic;genetic architecture;Genome;genome editing;genome integrity;Genome Stability;Genomic Instability;Goals;Human;human disease;Inherited;insight;Knowledge;Maintenance;Malignant Neoplasms;Methylation;microbial;Molecular;Molecular Genetics;Organism;overexpression;Oxytricha;Pathway interactions;Process;Public Health;Research;RNA;RNA Editing;RNA Processing;RNA-Binding Proteins;Role;System;tool;Tumor Promotion;Tumor Suppressor Genes;Untranslated RNA;Variant

PROJECT_TITLE: Understanding Complex Genome Editing and RNA Biology in Oxytricha


ADMINISTERING_IC: HD

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_CITY: SAINT LOUIS

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PEDIATRICS

ORG_FIPS: US

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: NARRATIVE This is a supplemental funding request for activities of the Intellectual and Developmental Disabilities Research Center (IDDRC) Brain Gene Registry (BGR) that falls entirely within the scope of the current P50 grant to Washington University (IDDRC) (P50HD103525). To accelerate the translational advances arising from the BGR, we propose to sustain patient accrual and use of the data contained in this powerful IDDRC Network resource. These initiatives build capacity and access to a shared IDD resource by investigators within and beyond the IDDRC network, as well as patient advocacy groups.

PI_NAMEs: DOUGHERTY, JOSEPH D;GURNETT, CHRISTINA  (contact)

PROGRAM_OFFICER_NAME: PARISI, MELISSA

PROJECT_TERMS: Acceleration;Administrative Supplement;Artificial Intelligence;Behavior assessment;Brain;Classification;Collaborations;Data;data access;Data Collection;data registry;Databases;electronic health information;Electronic Health Record;falls;Funding;Genes;Genotype;Grant;Growth;improved;Individual;Intellectual and Developmental Disabilities Research Centers;Intellectual functioning disability;Link;Methods;multimodal data;neurobehavioral;Participant;Pathogenicity;patient advocacy group;Patients;Persons;Phenotype;phenotypic data;Protocols documentation;rare variant;recruit;Registries;remote administration;Research Personnel;Resources;Site;Translational Research;United States National Institutes of Health;Universities;Variant;Washington

PROJECT_TITLE: WASHINGTON UNIVERSITY INTELLECTUAL AND DEVELOPMENTAL DISABILITIES RESEARCH CENTER


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: Boulder

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF COLORADO

ORG_STATE: CO

PHR: Project Narrative The goal of this supplement application is to purchase a PowerEdge R760xa rackmount computational server from Dell Technologies Inc. It will contain three NVIDIA H100 GPUs and will dramatically improve the throughput for our machine learning capabilities in model equation discovery and inference.

PI_NAMEs: BORTZ, DAVID  (contact)

PROGRAM_OFFICER_NAME: NGUYEN, HAN

PROJECT_TITLE: Data-driven and science-informed methods for the discovery of biomedical mechanisms and processes

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


ORG_CITY: LAWRENCE

ORG_NAME: UNIVERSITY OF KANSAS LAWRENCE

ORG_STATE: KS

PHR: Project Narrative The proposed research will facilitate development of modeling techniques capable of delivering starting points for structure-based drug design by providing structural information on docking modes of existing and potential drug targets.

PI_NAMEs: VAKSER, ILYA  (contact)

PROGRAM_OFFICER_NAME: CHO, THOMAS Y

PROJECT_TERMS: Assessment tool;automated assessment;Benchmarking;Binding;blind;Cell Physiology;Cells;Communities;Complex;data resource;Database Management Systems;Databases;Development;Docking;Drug Design;Drug Targeting;experimental study;frontier;Goals;Growth;improved;Individual;Joints;Kinetics;Knowledge;Libraries;Life;Macromolecular Complexes;macromolecule;Methodology;Modeling;molecular recognition;Molecular Structure;Probability;Procedures;Process;protein complex;Proteins;Protocols documentation;reconstruction;Research;Resource Development;Resources;Role;role model;Source;structural biology;Structural Models;Structure;System;Techniques;tool;Update;user-friendly;Visualization software

PROJECT_TITLE: Integrated Resource for Protein Recognition Studies

STUDY_SECTION: MSFD

STUDY_SECTION_NAME: Macromolecular Structure and Function D Study Section[MSFD]


NIH_SPENDING_CATS: Congenital Structural Anomalies;Kidney Disease;Pediatric;Polycystic Kidney Disease;Rare Diseases

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

ORG_STATE: NY

PHR: Narratives Centrosome and cilia dysfunction is prevalent in a wide range of diseases collectively called ciliopathy, including e.g. Bardet-Biedl syndrome, Joubert syndrome, Meckel-Gruber syndrome, polycystic kidney disease, and primary ciliary dyskinesia. However, how these cellular organelles form error-free from protein components scattered in the cell and what their physiological roles in most tissues remain elusive. A thorough understanding of the molecular pathways vertebrate cells employ to form and maintain the centrosome-cilium complex will allow for the development of therapeutic manipulations for some of these diseases.

PI_NAMEs: TSOU, MENG-FU BRYAN (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TERMS: Address;Alstrom syndrome;Amino Acids;Bardet-Biedl Syndrome;Biogenesis;Biological;Cells;Centrioles;Centrosome;Cilia;ciliopathy;Complex;Disease;DNA;equipment acquisition;Functional disorder;Genome;Higher Order Chromatin Structure;human disease;Individual;Joubert syndrome;Life;Meckel-Gruber syndrome;Modeling;Molecular;Organelles;Pathway interactions;Physiological;Polycystic Kidney Diseases;Primary Ciliary Dyskinesias;Proteins;Reproducibility;RNA;Role;Shapes;Structure;therapeutic development;Tissues;transmission process

PROJECT_TITLE: Supplements for Equipment Purchases


ORG_CITY: Chicago

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: Funds are requested for a Bruker ALPHA II FT-IR base unit to replace a broken ALPHA I unit in the PI’s lab. The purchase would restore an experimental setup that has been critical to research progress under the parent award.

PI_NAMEs: MANKAD, NEAL P (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TERMS: Administrative Supplement;Air;Atmosphere;base;Case Study;Data;Diamond;equipment acquisition;Funding;instrument;Literature;Measurement;Nitrogen;parent project;Research;Sampling;Spectroscopy, Fourier Transform Infrared

PROJECT_TITLE: Administrative Supplement to Purchase an FT-IR Spectrometer


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Digestive Diseases;Genetics;Immunotherapy;Orphan Drug;Pancreatic Cancer;Rare Diseases

ORG_CITY: LA JOLLA

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: Genomic studies show that 25% of pancreatic cancers harbor mutations in key genes (BRCA1/2, PALB2, and ATM) critical in homologous recombination (HR), an important type of DNA repair. These HR-deficient pancreatic cancers have a more aggressive disease course. Here we propose that polymerase theta (POLQ), a key enzyme that regulates an alternative pathway of DNA repair, is a new and highly effective therapeutic target in HR-deficient pancreatic cancer.

PI_NAMEs: SFEIR, AGNEL ;SIMEONE, DIANE M (contact)

PROGRAM_OFFICER_NAME: VENKATACHALAM, SUNDARESAN

PROJECT_TERMS: anti-tumor immune response;antitumor effect;ATM deficient;ATM gene;Biological;Biological Models;brca gene;BRCA1 gene;BRCA2 gene;Cancer Biology;cell killing;Cell Line;Cells;Characteristics;Chemoresistance;chemotherapeutic agent;chemotherapy;Clinical;clinical development;combinatorial;Combined Modality Therapy;Critical Pathways;Cytotoxic Chemotherapy;Data;Data Set;Defect;Development;Diagnosis;Disease;DNA Damage;DNA Double Strand Break;DNA Repair;DNA Repair Pathway;Double Strand Break Repair;efficacy testing;Enzymes;Genes;Genetic;Genetically Engineered Mouse;Genome Stability;Genomics;Germ-Line Mutation;Goals;Growth;homologous recombination;homologous recombination deficiency;Human;Human Characteristics;human model;immune activation;immune checkpoint blockade;Immune response;Immunotherapy;in vivo;inhibitor;Ionizing radiation;knock-down;Malignant neoplasm of pancreas;Malignant Neoplasms;Mediating;micronucleus;Modeling;mouse model;Mus;Mutation;neoplastic cell;new therapeutic target;Nonhomologous DNA End Joining;novel;novel therapeutics;Organoids;overexpression;PALB2 gene;Pancreatic Adenocarcinoma;pancreatic cancer cells;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;pancreatic ductal adenocarcinoma model;pancreatic tumorigenesis;Pathway interactions;patient derived xenograft model;Patients;Phenotype;Platinum;Poly(ADP-ribose) Polymerase Inhibitor;Poly(ADP-ribose) Polymerases;Polymerase;recombinational repair;Recurrence;Refractory;Regimen;Resistance;Resistance development;response;Role;Stimulator of Interferon Genes;Subgroup;T cell infiltration;targeted treatment;Testing;Therapeutic;Therapeutic Effect;therapeutic target;therapeutically effective;tumor;tumor growth;tumor microenvironment

PROJECT_TITLE: POLQ Synthetic Lethality in HR-Deficient Pancreatic Adenocarcinoma

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 1 Study Section[MCT1]


NIH_SPENDING_CATS: Neurosciences

ORG_DEPT: NEUROSCIENCES

PHR: PROJECT NARRATIVE  Eukaryotic circadian clocks impact nearly every aspect of physiology behavior. Their dysfunction contributes to cancer, as well as to mental illness (e.g., depression) and to metabolic diseases (e.g., diabetes). While we know a great deal about the details of molecular timekeeping within pacemaker cells, we know relatively little about how clock information is used. Circadian output generates a series of signals representing phase markers, according to which diverse downstream tissues and circuits bias their daily temporal activities. We will study the generation of circadian phase in Drosophila at the levels of behavior, neurophysiology, neuroendocrinology and intracellular signaling pathways. The detailed mechanisms thus revealed will help deﬁne how clock information underlies normal physiology and also pathophysiology.

PI_NAMEs: TAGHERT, PAUL H (contact)

PROGRAM_OFFICER_NAME: AKACEM, LAMEESE DANA

PROJECT_TERMS: Behavior;Biological Models;Brain;brain control;Cell Communication;Cells;circadian;circadian pacemaker;Dedications;Diabetes Mellitus;Drosophila genus;fly;Functional disorder;Generations;Goals;Hormones;Laboratory Study;Malignant Neoplasms;Mental Depression;Mental disorders;Metabolic Diseases;Modeling;Molecular;molecular clock;neural circuit;Neuroendocrinology;neuromechanism;Neurons;Neuropeptides;neurophysiology;nodal myocyte;Output;Pacemakers;Periodicity;Phase;Physiology;programs;Research;Series;Signal Pathway;Signal Transduction;Sleep;Stereotyping;System;Temperature;Testing;Time;Tissues;transmission process;Work

PROJECT_TITLE: The Generation of Multi-Phasic Circadian Output


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Biotechnology;Immunization

ORG_CITY: Boston

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: TUFTS UNIVERSITY MEDFORD

ORG_STATE: MA

PHR: Antibodies are invaluable in basic biomedical research and biotechnology, but lack chemical features that facilitate enzyme inhibition, covalent target engagement, and other function-disrupting bioactivities. This program seeks to advance the yeast-based biosynthesis and high throughput screening of “chemically expanded” antibodies. Our investigations will lead to inhibitors for studying how cells move, interact with their surroundings, and signal with one another while also revealing crucial principles of protein biosynthesis and enzyme inhibitor discovery.

PI_NAMEs: VAN DEVENTER, JAMES ALLEN (contact)

PROGRAM_OFFICER_NAME: ASLAN, KADIR

PROJECT_TERMS: Acoustics;Amino Acids;Anabolism;Antibodies;Antibody Diversity;antibody libraries;Binding Proteins;Biomedical Research;Biotechnology;cell type;Cells;Chemicals;Chemistry;design;Engineering;Enzyme Inhibition;Enzyme Inhibitor Drugs;Escherichia coli;Generations;Genetic;Genetic Code;Genomics;high throughput screening;human disease;Hybrids;improved;inhibitor;Investigation;Lasers;Mammalian Cell;Mediating;Metalloproteases;Molecular;molecular recognition;Organism;Positioning Attribute;programs;Protein Biosynthesis;Protein Tyrosine Phosphatase;Proteins;Reagent;Research;Side;Signal Transduction;small molecule;success;synthetic antibodies;System;tool;Translations;Viola;Work;Yeasts

PROJECT_TITLE: Attune NxT Acoustic Focusing Cytometer (blue/red/violet/yellow laser)


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Breast Cancer;Cancer;Cancer Genomics;Genetics;Human Genome;Women's Health Research

ORG_CITY: GRAND FORKS

ORG_NAME: UNIVERSITY OF NORTH DAKOTA

ORG_STATE: ND

PHR: PROJECT NARRATIVE In human cells, genomic DNAs are associated with histones and form chromatin structure. Precise organization of chromatin structure is critical during cellular development and reprogramming, and their misregulation leads to various human diseases including cancer. This grant aims to identify the molecular mechanisms underlying chromatin reorganization using a cellular reprogramming model in breast cancer cells.

PI_NAMEs: TAKAKU, MOTOKI  (contact)

PROGRAM_OFFICER_NAME: CHOW, CHI-WING

PROJECT_TERMS: Architecture;Binding;Binding Sites;Biological;Biological Models;Breast Cancer Cell;Cell Reprogramming;Cells;cellular development;Chromatin;chromatin remodeling;Chromatin Structure;Complex;Cryoelectron Microscopy;DNA;Enabling Factors;Enhancers;Enzymes;epithelial to mesenchymal transition;Epithelium;GATA3 gene;Gene Activation;Genetic Markers;Genomic DNA;genomic locus;Goals;Grant;Histones;Human;human disease;Human Genome;Malignant Neoplasms;Maps;Methods;Modeling;Molecular;Molecular Conformation;novel strategies;Nucleosomes;Positioning Attribute;Process;Proteins;Resolution;Role;Site;Structure;transcription factor;triple-negative invasive breast carcinoma

PROJECT_TITLE: Role of nucleosome architecture in cellular reprogramming

STUDY_SECTION: MSFC

STUDY_SECTION_NAME: Macromolecular Structure and Function C Study Section[MSFC]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Influenza;Lung;Orphan Drug;Pneumonia and Influenza;Rare Diseases

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: PROJECT NARRATIVE Viral lung infection is a major cause of severe lung injury and death. This proposal aims to gain new understanding of how viruses, specifically influenza, cause lung injury, with the overall goal of identifying new treatment approaches that decrease lung injury and increase survival. The ongoing COVID-19 pandemic and threat of future pandemics by other viruses, including influenza, give special importance to this research.

PI_NAMEs: HOOK, JAIME LYNN (contact)

PROGRAM_OFFICER_NAME: ESPINOZA GRANDON, INGRID CECILIA

PROJECT_TERMS: Accounting;Acute Lung Injury;Address;Adult;Alveolar;alveolar epithelium;Alveolar wall;Alveolus;Anatomy;Catalytic Domain;Cell Culture Techniques;Cessation of life;Child;co-infection;Confocal Microscopy;COVID-19 pandemic;Critical Illness;Cystic Fibrosis Transmembrane Conductance Regulator;Data;Death Rate;Defense Mechanisms;Edema;Enzymes;Excess Mortality;Functional disorder;Funding;future pandemic;Goals;Hemolysin;Hospitalization;Human;Influenza;Influenza A virus;influenza infection;Inhalation;inhibitor;insight;Leucine;Liquid substance;Lung;Lung infections;lung injury;Measures;Mediating;Methods;Methylation;Methyltransferase;Mission;Molecular;mortality;mouse model;Mus;mutant;National Heart, Lung, and Blood Institute;new therapeutic target;novel therapeutic intervention;pandemic virus;parent project;particle;pathogen;Patients;Persons;Pharmaceutical Preparations;Phosphoric Monoester Hydrolases;Phosphorylation;plasmid DNA;Population;prevent;Protein Dephosphorylation;Protein phosphatase;Proteins;Pulmonary alveolar structure;Pulmonary Edema;Research;Respiratory Failure;response;restoration;Role;secondary infection;Secondary to;Small Interfering RNA;Staphylococcus aureus;Staphylococcus aureus infection;therapeutic evaluation;Time;Toxin;Transgenic Mice;United States;Viral;Virus;Virus Diseases;Wild Type Mouse

PROJECT_TITLE: Research Supplement for Alveolar Responses to Viral Lung Infection

STUDY_SECTION: LIRR

STUDY_SECTION_NAME: Lung Injury, Repair, and Remodeling Study Section[LIRR]


NIH_SPENDING_CATS: Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: PROJECT NARRATIVE  The goal of this supplemental application is to request funding to purchase a new instrument (cryostat). The original Narrative document has not changed as a result of the proposed supplement activity.

PI_NAMEs: DAI, XING  (contact)

PROGRAM_OFFICER_NAME: SALAZAR, DESIREE LYNN

PROJECT_TITLE: Intrinsic and extrinsic control of epithelial tissue stem cell activity


NIH_SPENDING_CATS: Arctic;Biotechnology;Brain Disorders;Cerebrovascular;Genetics;Neurosciences;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Stroke

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative The overarching goal of our research program is to identify novel cytoprotective genes and mechanisms that protect cells against oxidative, metabolic and hypoxic/ischemic stresses using diverse and complementary model systems. The outcome of our research program may help advance our basic understanding of principles for cell physiological homeostasis and adaptation to stress, as well as develop biomedical applications in therapeutic hypothermia and new treatments for metabolic, neurological and ischemic disorders.

PI_NAMEs: MA, DENGKE  (contact)

PROGRAM_OFFICER_NAME: NIE, ZHONGZHEN

PROJECT_TERMS: Abnormal Cell;adenovirus mediated delivery;arctic ground squirrel;Behavior;Behavioral Assay;behavioral phenotyping;Biochemical Process;biological adaptation to stress;Biological Assay;Biological Models;Brain Hypoxia-Ischemia;Caenorhabditis elegans;California;Cardiovascular system;Cell Separation;Cells;Cellular Morphology;cold temperature;coping;CRISPR/Cas technology;Cytoprotection;Disease;effectiveness evaluation;experience;Exposure to;Gene Expression Profiling;Genes;Genetic;genetic analysis;Genetic Determinism;Genetic Screening;Goals;Grant;Homeostasis;Hypoxia;Immunofluorescence Immunologic;innovation;insight;interdisciplinary approach;interest;Ischemia;Knowledge;Laboratories;Life;live cell imaging;Mediating;Metabolic;Metabolic stress;Metabolism;Microscopy;Monitor;Mus;mutant;Mutation;Myocardial Infarction;natural hypothermia;nerve stem cell;Neurologic;novel;novel therapeutic intervention;novel therapeutics;Organ Transplantation;Organism;Outcome;Oxidative Stress;Oxygen;Pathway interactions;Physiological;Physiological Adaptation;Physiology;Productivity;programs;Property;Proteins;Recombinants;Research;Research Institute;resilience;response;response biomarker;RNA Interference;RNA interference screen;Role;Running;San Francisco;Spermophilus;Stress;stress resilience;stress tolerance;Stroke;Techniques;Technology;Temperature;Therapeutic;Therapeutic procedure;tissue injury;tool;Universities;Variant;Visualization

PROJECT_TITLE: Genetic pathway and cellular mechanism underlying organismic responses to hypoxia and hypothermia


NIH_SPENDING_CATS: Lung;Pulmonary Fibrosis;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Intermediate progenitor cells arise from different lung stem cell populations following mammalian lung injury. They have been shown to differentiate into AT1 cells, thus aiding alveolar repair; however, they have also been implicated in lung disease. This project will define the dynamic cellular behaviors and molecular regulatory landscape that drives IPC transitions toward repair.

PI_NAMEs: CHIOCCIOLI, MAURIZIO  (contact)

PROGRAM_OFFICER_NAME: GOMEZ, CHRISTIAN RENE

PROJECT_TERMS: Ablation;Acute;Alveolar;alveolar epithelium;Alveolus;Architecture;Behavior;Biology;Bleomycin;cell behavior;Cell Lineage;Cells;Cessation of life;Data Set;Epithelial Cells;Epithelium;Homeostasis;Human;human disease;Image;in vivo;in vivo regeneration;Injury;Lasers;life span;Lung;Lung Diseases;lung injury;Mammals;Modeling;Molecular;mouse model;Mus;Neighborhoods;parent grant;predictive modeling;preservation;Process;Pulmonary Fibrosis;repaired;Reporter;response;stem cell population;stem cells;Time;transcriptomics;Virus

PROJECT_TITLE: Defining the cellular dynamics that orchestrate alveolar epithelial cell repair behaviors in live mammal


ORG_NAME: NORTHWESTERN UNIVERSITY

PHR: Project Narrative ATP-binding cassette (ABC) transporters utilize many mechanisms to ensure efficient nutrient uptake while regulating toxins. Regulatory domains are not conserved in all ABC importers, indicating more variability in ABC importers beyond the current Type I/II classification scheme (Rice, Park et al., 2014). The proposed research will define the mechanism in which transporters can shut off transport based on environmental cues, which is a critical, but often overlooked, aspect to understanding basic nutrient uptake and survival mechanisms.

PI_NAMEs: PINKETT, HEATHER WENDY (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TITLE: Regulation mechanisms of ABS transporters

STUDY_SECTION: MSFA

STUDY_SECTION_NAME: Macromolecular Structure and Function A Study Section[MSFA]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Biotechnology;Diabetes

ORG_CITY: RIVERSIDE

ORG_NAME: UNIVERSITY OF CALIFORNIA RIVERSIDE

PHR: PROJECT NARRATIVE The overall objective of this proposal is to achieve fundamental understanding of protein activities that are impacted by abnormal ganglioside expression and to investigate the linkage of such abnormality to diseases such as cancer and diabetes. The research aims to identify key factors that influence complex ganglioside-protein interactions with a new technology platform. The results will provide molecular basis for effective search of anti-cancer and diabetes therapeutics.

PI_NAMEs: CHENG, QUAN JASON (contact)

PROGRAM_OFFICER_NAME: BOND, MICHELLE RUEFFER

PROJECT_TERMS: Affinity;Anabolism;anti-cancer;Applications Grants;Binding;Biochemical;Biomimetics;Biophysics;Blood Cells;Bypass;caveolin 1;Cell Adhesion;Cell Physiology;Cells;Complex;Diabetes Mellitus;Disease;Environment;Epidermal Growth Factor Receptor;Epithelial Cells;Event;Family;Gangliosides;Glycocalyx;Glycolipids;Glycoproteins;Human body;Immune;Inflammation;Insulin;Insulin Receptor;Insulin Resistance;KDR gene;Killer Cells;Libraries;Link;Malignant Neoplasms;Mediating;Membrane;Membrane Proteins;Molecular;Nerve Regeneration;Neurons;neuroregulation;new technology;Non-Insulin-Dependent Diabetes Mellitus;novel;parent grant;Pathology;Play;Polysaccharides;Property;protein function;Proteins;Research;Role;Spectrum Analysis;Structure-Activity Relationship;Surface Plasmon Resonance;System;Techniques;technology platform;Therapeutic;therapeutic target;Toxic effect;tumor;tumor progression

PROJECT_TITLE: Glycolipid biointerface to decipher disease-implicated ganglioside-protein interactions

STUDY_SECTION: EBIT

STUDY_SECTION_NAME: Enabling Bioanalytical and Imaging Technologies Study Section[EBIT]


PHR: NARRATIVE: ADMINISTRATIVE SUPPLEMENT FOR EQUIPMENT (NOT-GM-24-021) Funds are requested to purchase the Liberty PRIME 2.0 HT12 automated peptide synthesizer. The Adibekian laboratory currently lacks an automated peptide synthesizer, necessitating the tedious manual synthesis of shorter peptides using solid-phase synthesis. Acquiring the Liberty PRIME automated synthesizer will significantly enhance our experimental capabilities and accelerate our R01 research program, thereby advancing the mission of the NIGMS and NIH.

PI_NAMEs: ADIBEKIAN, ALEXANDER  (contact)

PROGRAM_OFFICER_NAME: BARNES, CHARLES ASHLEY

PROJECT_TERMS: Acceleration;Administrative Supplement;Amino Acid Sequence;Chemicals;Equipment;Freedom;Funding;Laboratories;Manuals;Membrane Proteins;Mission;Molecular Conformation;National Institute of General Medical Sciences;parent grant;Peptides;programs;Reaction;Research;S phase;Solid;Structure;United States National Institutes of Health

PROJECT_TITLE: Probing conformational changes by protein surface azidation


ORG_DEPT: BIOLOGY

PHR: NARRATIVE Plugging & Pulling-in: tuning peptides for TolC to overcome antibiotic resistance Narrative Antibiotic resistance is an increasingly dire global health challenge. Antibiotic efflux pumps push antibiotics out of bacterial cells so that antibiotics cannot reach their targets. We plan to identify features of peptides that bind efflux pumps to either 1) plug the pumps to potentiate antibiotics or 2) pull through the pumps for drug delivery.

PI_NAMEs: SLUSKY, JOANNA SG (contact)

PROGRAM_OFFICER_NAME: FABIAN, MILES

PROJECT_TERMS: Affinity;antibiotic efflux;Antibiotic Resistance;antibiotic resistant infections;Antibiotics;beta barrel;Binding;Binding Proteins;Cells;Clinical;combat;Databases;Development;Drug Delivery Systems;Effectiveness;efflux pump;Escherichia coli;experimental study;global health;Goals;HIV/AIDS;Knowledge;Malaria;Membrane;Membrane Proteins;Outcome;overexpression;Parents;Peptides;Persons;Pharmaceutical Preparations;Pharmacologic Substance;protein protein interaction;Protein translocation;Proteins;Pump;Research;Resistance;Structure;success;Superbug;Work

STUDY_SECTION: BBM

STUDY_SECTION_NAME: Biochemistry and Biophysics of Membranes Study Section[BBM]


NIH_SPENDING_CATS: Aging;Genetics

ORG_CITY: DAVIS

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Narrative In the human body, rhythms of metabolism play an essential role in maintaining normal function. Disrupting these rhythms can contribute to many types of disease, including diabetes, cancer, and aging. However, the effect that metabolic rhythms have on cells is still not fully understood. This study will investigate how changing metabolic rhythms can activate or deactivate certain genes, helping us to understand the connection between these rhythms and disease.

PI_NAMEs: ALBECK, JOHN G. (contact)

PROGRAM_OFFICER_NAME: XU, JIANHUA

PROJECT_TERMS: Aging;Autophagocytosis;Biological Assay;cell growth;cell growth regulation;Cells;Chronic Disease;Diabetes Mellitus;Disease;drug sensitivity;FOXO3A gene;Gene Expression;Genes;Genetic Transcription;Human body;inducible gene expression;Inflammation;inhibitor;Kinetics;Lysosomes;Malignant Neoplasms;mathematical model;Measures;Metabolic;Metabolic stress;Metabolism;Metformin;Methods;Modeling;novel strategies;pharmacologic;Play;Process;programs;Reporter;response;Role;senescence;Stress;Systems Biology;Testing;transcription factor;transcriptome;Translations;Work

PROJECT_TITLE: Control of gene expression by dynamic metabolic oscillations

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(55)-R]


ORG_DEPT: OTHER BASIC SCIENCES

PHR: 1 Project Narrative (three sentences). Sulfated molecules, their interacting partners and 2 associated signaling complexes play critical roles in the health of humans and other 3 species. Our research will reveal fundamental mechanisms governing these processes. 4 Knowledge gained from the study will guide strategies to develop peptide-based 5 reagents capable of inhibiting or activating molecular interactions with a high degree of 6 affinity and specificity with potential applications in research, agriculture and medicine.

PI_NAMEs: RONALD, PAMELA C (contact)

PROGRAM_OFFICER_NAME: LEWIS, MECHELLE MAYLEBEN

PROJECT_TERMS: 3-Dimensional;Address;Affinity;Agriculture;Animals;Antigen-Antibody Complex;Area;Awareness;Bacteria;Binding;Biological Assay;Biological Process;blood treatment;Cardiovascular Diseases;Cell surface;Cells;Coagulation Process;Complex;Development;Engineering;Fluorescence;Foundations;gene discovery;Goals;Health;HIV;Human;Immune;Immune response;insight;Knowledge;Ligand Binding;Ligands;Medicine;microorganism interaction;Microscopy;Modification;mutant;novel;Peptides;Phenotype;Plants;Play;Positioning Attribute;Process;Proteins;Reagent;receptor;Research;response;Role;Signal Transduction;Specificity;Spectrometry;Sulfate;therapeutic evaluation;Ticks;tool;tyrosine O-sulfate;United States National Institutes of Health;whole genome;Yeasts

PROJECT_TITLE: Fluorescence stereo microscopy for exploring the three-dimensional dynamics of receptor ligand interactions


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biotechnology

ORG_DEPT: BIOMEDICAL ENGINEERING

PHR: PUBLIC HEALTH RELEVANCE Extracellular vesicles can be used to treat various diseases, but their inherent heterogeneity and low yield have prevented them from easily translating to the clinic. Here we will synthesize scalable nanoparticles from the bottom up that mimic the effects of natural vesicles. The proposed research will create an effective platform for designing and testing extracellular vesicles with high efficacy.

PI_NAMEs: CARNEY, RANDY ;TAN, CHEEMENG  (contact);WANG, AIJUN

PROGRAM_OFFICER_NAME: CHEN, JERMONT

PROJECT_TERMS: Address;Biological;Biological Models;Cell secretion;Cells;Clinic;clinical application;Complex;Coupled;delivery vehicle;design;Disease;Drug Delivery Systems;extracellular vesicles;Heterogeneity;immunoregulation;In Vitro;in vivo Model;insight;intercellular communication;interest;Mesenchymal;Methods;mimetics;Molecular;nanoparticle;Nervous System Disorder;neuroprotection;Play;prevent;Production;Proteins;prototype;public health relevance;Quality Control;Reproducibility;Research;RNA;Role;Set protein;Standardization;stem;Stromal Cells;synthetic biology;Testing;Therapeutic;Therapeutic Effect;Translating;Vesicle;Work

PROJECT_TITLE: Bottom-up, high-throughput prototyping of extracellular vesicle mimetics using cell-free synthetic biology


NIH_SPENDING_CATS: Genetics;Infectious Diseases;Networking and Information Technology R&D (NITRD)

ORG_CITY: CHICAGO

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF CHICAGO

PHR: PROJECT NARRATIVE Geography plays an important role in structuring genetic variation in numerous species that are relevant to human health. This project will develop novel theoretical models and computational tools to empower researchers to analyze and interpret the geographic distribution of genetic variation, with an emphasis on understanding neutral, deleterious, and adaptive genetic variants.

PI_NAMEs: NOVEMBRE, JOHN  (contact)

PROGRAM_OFFICER_NAME: WANG, PEGGY

PROJECT_TERMS: Alleles;Area;Communicable Diseases;computerized tools;Data;Detection;empowerment;Gene Frequency;Genetic;Genetic Structures;genetic variant;Genetic Variation;genome wide association study;Geographic Distribution;Geography;Graph;Health;Human;Human Genetics;Individual;loss of function;Mediating;Methods;migration;model building;novel;pathogen;Pattern;Play;Population;Population Genetics;Process;Reproduction;Research;Research Personnel;Resources;Role;Sampling;Series;Structure;Theoretical model;theories;trait;Variant;Visualization

PROJECT_TITLE: Theory, Methods, and Resources for Understanding and Leveraging Spatial Variation in Population Genetic Data


NIH_SPENDING_CATS: Natural Products

PHR: PROJECT NARRATIVE This proposal outlines plans for the development of new methods and general strategies for chemical synthesis of complex, bioactive organic compounds. The results from this endeavor will produce new synthesis “tools” that will enable medicinal chemists in academia, government labs, and the pharmaceutical industry to more easily access intricate molecules that are needed for biomedical studies and for the development of pharmaceutical drugs. The challenging projects that will be examined will provide excellent problem-solving skills and training in synthetic organic chemistry for graduate students and postdoctoral associates and prepare them for careers in biomedical fields.

PI_NAMEs: RAWAL, VIRESH H. (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TERMS: Academia;Alkaloids;career;chemical synthesis;Complex;Development;Development Plans;Drug Industry;enantiomer;Ensure;Equipment;experience;Funding;Government;graduate student;High Pressure Liquid Chromatography;high standard;Indole Alkaloids;Medicine;Methods;Natural Products;Organic Chemistry;Pharmaceutical Preparations;Pharmacologic Substance;Postdoctoral Fellow;pressure;Problem Solving;Process;Reaction;Research;skills;Solvents;System;tool;Training;United States National Institutes of Health;Work

PROJECT_TITLE: Equipment Supplement: Methods and Strategies for the Concise Synthesis of Complex Alkaloid Natural Products

STUDY_SECTION: SBCA

STUDY_SECTION_NAME: Synthetic and Biological Chemistry A Study Section[SBCA]


NIH_SPENDING_CATS: Aging;Cardiovascular;Cerebrovascular;Clinical Research;Contraception/Reproduction;Endometriosis;Fibroid Tumors (Uterine);Heart Disease;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: SALT LAKE CITY

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Project Narrative This diversity supplement will advance the understanding of the association between fibroids, endometriosis and risk of cardiovascular disease risk factors, considering sociodemographic characteristics and reproductive history. Understanding these associations will help improve the identification of women who are at high risk for cardiovascular disease, which may allow for early interventions and ultimately reduce morbidity and mortality.

PI_NAMEs: FARLAND, LESLIE V;SCHLIEP, KAREN C. (contact)

PROGRAM_OFFICER_NAME: PUGGAL, MONA A

PROJECT_TERMS: Accounting;adverse pregnancy outcome;Affect;African American;Age;American Heart Association;Arizona;Benign;Blood Banks;Brain Infarction;brain magnetic resonance imaging;Cardiac;cardiometabolism;Cardiovascular Diseases;cardiovascular disorder epidemiology;cardiovascular disorder prevention;cardiovascular disorder risk;Cardiovascular system;career development;Cause of Death;cerebral microbleeds;Cerebrovascular Disorders;Characteristics;Chronic;Chronic Kidney Failure;clinical risk;cohort;college;coronary calcium scoring;Coronary heart disease;Data;design;Development;Diagnosis;Disease Outcome;disparities in women;Doctor of Philosophy;doctoral student;Dyslipidemias;Early Intervention;Eligibility Determination;Endometriomas;endometriosis;Epidemiology;Ethnic Origin;Etiology;Event;experience;Female;Fibroid Tumor;follow-up;Follow-Up Studies;Funding;Glucose;Goals;Gynecologic;Health;high risk;Hispanic;Hyperlipidemia;Hypertension;improved;Individual;Infertility;Infiltration;Inflammation;Inflammatory;Insulin;Knowledge;knowledge base;Lesion;Life course epidemiology;Life Cycle Stages;life span;Link;Lipids;Longitudinal cohort study;Longitudinal Studies;marginalization;Measures;Mediating;Medical;Medical Electronics;Mentors;Metabolic syndrome;middle age;Morbidity - disease rate;mortality;National Institute of Child Health and Human Development;Non-Insulin-Dependent Diabetes Mellitus;Outcome;parent grant;parent project;Participant;Patients;Population;Population Database;Population Heterogeneity;Positioning Attribute;Postdoctoral Fellow;programs;Public Health;Race;Records;reproductive;Reproductive History;reproductive system disorder;Research;Risk;Risk Factors;risk stratification;Sample Size;Scanning;skills;sociodemographics;Time;Training;Universities;Utah;Uterine Fibroids;Visit;Vital Status;white matter;Woman;Women's Health;X-Ray Computed Tomography;young adult

PROJECT_TITLE: Endometriosis Diagnosis and Subtypes, Reproductive History, and Cardiovascular Disease


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Pediatric;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: CHAPEL HILL

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Improving the health outcomes for infants has been a national priority in the US for over a century. Further improvements in perinatal health outcomes of the nation’s children as well as progress towards closing of persistent Black-White disparities, will require studying and addressing the maternal social environment across the life course.

PI_NAMEs: SLAUGHTER-ACEY, JAIME CATHERINE (contact)

PROGRAM_OFFICER_NAME: BRAUDT, DAVID BRUCE

PROJECT_TERMS: Address;Affect;Aging;American;Archives;Back;Behavioral;Biological Aging;Biological Assay;Biological Markers;Birth;Birth Weight;Black Populations;Black race;black women;black/white disparity;Blood;Child;cohort;critical period;Cross-Sectional Studies;Data;DNA Methylation;Enrollment;Environment;Environmental Risk Factor;Epigenetic Process;epigenome;epigenomics;Family;Fetal Growth;Generations;Genomics;Health;health determinants;Healthcare;improved;indexing;Individual;infant outcome;insight;Length;Life Cycle Stages;Link;maternal stress;Measures;Mediating;Methylation;minority health;Modeling;Mothers;Neighborhoods;Newborn Infant;novel strategies;offspring;Outcome;Pathway interactions;Perinatal;perinatal health;perinatal outcomes;Population;Pregnancy;Pregnant Women;Premature Birth;prenatal;Race;racial disparity;racism;Research;Research Personnel;Risk;Role;Sampling;Site;social;Social Environment;social factors;Socioeconomic Status;sound;Source;Spottings;Stress;Stress and Coping;stressor;success;telomere;Theoretical model;Time;United States;Validation;Variant;Woman;Work

PROJECT_TITLE: Looking Back to Look Forward: Social Environment Across the Life Course, Epigenetics, and Birth Outcomes in Black Families


NIH_SPENDING_CATS: Bioengineering;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative A high performance computing resource from the Minnesota Supercomputing Institute at the University of Minnesota dedicated to our research group will allow a fast and parallelizable training and testing process without delaying job executions and leading to job failures. Ultimately, our methods and algorithms to be developed have the potential to narrow the gap from raw molecular data to deep biological insights.

PI_NAMEs: SAFO, SANDRA E (contact)

PROJECT_TERMS: Address;Algorithms;Big Data;Biological;Biological Process;Communities;Complex;complex data;computing resources;Data;Dedications;Disease;Failure;Funding;Generations;high dimensionality;High Performance Computing;improved;insight;Intervention;Knowledge;Link;machine learning method;Medicine;Memory;Methods;Minnesota;Molecular;multimodal data;multiple omics;Occupations;parallel processing;parent grant;patient stratification;Process;Research;Resources;Running;simulation;Speed;statistical and machine learning;Supercomputing;System;Technology;Testing;Time;Training;Universities

PROJECT_TITLE: Statistical and Machine Learning Methods to Address Biomedical Challenges for Integrating Multi-view Data (Supplement)


PHR: Project Narrative NA

PI_NAMEs: TOCZYSKI, DAVID PAUL (contact)

PROGRAM_OFFICER_NAME: MACARTHUR, LINDA

PROJECT_TERMS: Post-Translational Protein Processing;Post-Translational Regulation;response;Stress

PROJECT_TITLE: Regulation by post-translation modifications in response to stress


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Kidney Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Urologic Diseases

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

PHR: Laser lithotripsy (LL) is commonly used for kidney stone treatment, with cavitation playing a crucial role in stone fragmentation. This supplement study will utilize deep learning to predict stone damage based on passive cavitation mapping (PCM) signals. Our approach will offer valuable insights into medical practice, advancing the efficacy of LL treatments, and improve the patient outcomes.

PI_NAMEs: LIPKIN, MICHAEL E;YAO, JUNJIE  (contact);ZHONG, PEI

PROGRAM_OFFICER_NAME: KIRKALI, ZIYA

PROJECT_TERMS: 3-Dimensional;Administrative Supplement;Adopted;Algorithms;Automobile Driving;Bathing;Clinical;clinical application;clinical practice;Data;data acquisition;Data Set;data-driven model;deep learning;deep learning model;design;Disease;empowerment;Ensure;feature selection;Feedback;Funding;Goals;Grant;Health;human model;Image;image processing;Implant;improved;In Vitro;in vitro Model;in vivo Model;insight;Kidney;Kidney Calculi;large datasets;Laser Lithotripsy;Lasers;Learning Module;Lithotripsy;Maps;Medical;Medical Imaging;Modeling;Monitor;National Heart, Lung, and Blood Institute;parent grant;parent project;Parents;Patient-Focused Outcomes;Patients;Physiologic pulse;Play;porcine model;predictive modeling;Procedures;real time monitoring;reconstruction;Research;response;Role;Signal Transduction;Spatial Distribution;standard of care;Surface;System;Techniques;Technology;Testing;Time;Training;training data;Translating;Treatment Efficacy;ultra high resolution;ultrasound;United States National Institutes of Health;Universities;Urinary Calculi;Water

PROJECT_TITLE: 3D real-time super-resolution cavitation mapping in laser lithotripsy of urinary stone disease


NIH_SPENDING_CATS: Genetics;Human Genome

PHR: PROJECT NARRATIVE Francois Jacob, the pioneering molecular geneticist, said that "The dream of every cell is to become two cells". In humans, the 6.2 billion DNA letters that encode the information for building and maintaining our bodies are organized into 46 chromosomes that must be copied and then precisely distributed to produce two identical daughter cells; errors in the distribution of chromosomes cause birth defects and contribute to the ability of cancers to develop and evade treatment. The goals of this project are to address how cells achieve the Jacobian dream, preserving the integrity of their genomes through the process of division.

PI_NAMEs: DESAI, ARSHAD  (contact)

PROGRAM_OFFICER_NAME: MILLER, RITA K

PROJECT_TERMS: Acceleration;Address;Adult;Astronomy;aurora kinase A;Back;Cell division;Cell Physiology;Cells;Chromatin;Chromosome Segregation;Chromosomes;Complex;Congenital Abnormality;daughter cell;Development;DNA;Dreams;Ensure;Event;Genetic Complementation Test;Genetic Transcription;Genome;Genomics;Goals;Heart;Human;Human body;Infertility;Kinetochores;Letters;loss of function;Malignant Neoplasms;Mechanics;Microtubules;Mitosis;Mitotic;Mitotic Chromosome;Molecular;novel therapeutics;Organism;Phase;preservation;prevent;Process;Proteins;segregation;Set protein;Signal Transduction;Specific qualifier value;Therapeutic;Time;Translations;Work

PROJECT_TITLE: Kinetochore Specification and Function


NIH_SPENDING_CATS: Biotechnology;Digestive Diseases;Gene Therapy;Genetics;Hepatitis;Hepatitis - C;Infectious Diseases;Liver Disease

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

PHR: Project Narrative - NO CHANGES RNA silencing is a natural process by which small RNAs “silence” genes (or turn genes off), and is required for fertility, brain development, and prevention of cancer. This project aims to understand how small RNAs control gene expression in humans. The proposed research will lead to a better understanding of human gene regulation and contribute to advances in harnessing RNA silencing for the treatment of human disease.

PI_NAMEs: MACRAE, IAN JOHN (contact)

PROGRAM_OFFICER_NAME: CZAPLINSKI, KEVIN

PROJECT_TERMS: Address;Animals;Area;Biochemical;Biological Process;Biology;Brain;cancer prevention;Cells;Complex;Cullin Proteins;Development;DNA Transposable Elements;Double-Stranded RNA;Fertility;Gene Expression;Gene Expression Regulation;Gene Silencing;Genes;Genome;Health;Hepatitis C virus;Human;human disease;insight;Integral Membrane Protein;Knowledge;Liver;Mammals;Membrane Transport Proteins;Messenger RNA;MicroRNAs;Molecular Genetics;piRNA;Process;Production;protein complex;Research;RNA;RNA Interference;RNA Transport;RNA Viruses;Small Interfering RNA;Small RNA;Structural Biochemistry;structural biology;Structure;therapeutic RNA;Transcriptional Silencer Elements;Translations;ubiquitin-protein ligase;Ubiquitination;Viral;Viral Genome;viral RNA;Virus Diseases;Work

PROJECT_TITLE: Structural and Mechanistic basis for RNA Silencing


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Regenerative Medicine

ORG_CITY: EUGENE

ORG_NAME: UNIVERSITY OF OREGON

ORG_STATE: OR

PHR: PROJECT NARRATIVE Disrupted organ size control mechanisms underlie a multitude of birth defects, deficient tissue repair, and cancer. The proposed research studies cellular and molecular processes that perfectly restore size and scale during an astonishing example of innate vertebrate organ regeneration. As such, the project will uncover conceptual and specific mechanisms that may be disrupted in human disease while also guiding novel regenerative medicine approaches.

PI_NAMEs: STANKUNAS, KRYN  (contact);STEWART, SCOTT J

PROGRAM_OFFICER_NAME: PHILLIPS, ANDRE W

PROJECT_TERMS: Adult;bioelectricity;blastema;Bone Diseases;Calcineurin;candidate identification;cell behavior;Cell membrane;Cells;Congenital Abnormality;Distal;Ectopic Expression;Exhibits;Fibroblasts;Genes;Growth;Homeostasis;Human;human disease;Injury;Ions;Link;Malignant Neoplasms;Mesenchyme;Modeling;Molecular;mutant;Mutate;Natural regeneration;novel;Organ;organ regeneration;Organ Size;Phenotype;Potassium Channel;Process;regenerative;Regenerative Medicine;Reporter Genes;Research;research study;Shapes;Signal Transduction;skeletal regeneration;spatiotemporal;System;Testing;tissue repair;transcriptomics;Transgenic Organisms;tumor;voltage;Voltage-Gated Potassium Channel;Zebrafish

PROJECT_TITLE: Ion signaling, cell transitions, and organ scaling during fin regeneration


NIH_SPENDING_CATS: Biotechnology

PHR: Project Narrative This proposal centers on the development of novel chiral catalysts and new approaches to achieve the enantioselective sp3 C–H activation of readily-available carboxylic acids, ketones and amines. These reactions will provide new strategies for constructing α-, β- and γ-stereocenters; broadly useful in asymmetric syntheses of chiral bioactive compounds and drug molecules. In a collaborative effort, these new synthetic technologies will be applied to the discovery of promising new drug candidates for the treatment of human diseases.

PI_NAMEs: YU, JIN-QUAN  (contact)

PROJECT_TERMS: Acceleration;activity-based protein profiling;Address;Aldehydes;Amines;Carbon;Carboxylic Acids;catalyst;Collaborations;Cysteine;Development;drug candidate;drug discovery;Drug Industry;human disease;Hydrogen Bonding;inhibitor;Ketones;Laboratories;Lactams;Lactones;Ligands;Metals;novel;novel strategies;novel therapeutics;Organic Synthesis;Pharmaceutical Preparations;Proteins;Pyridones;Reaction;Serine Hydrolase;Technology

PROJECT_TITLE: Ligand-promoted Enantioselective C-H Activation Reactions

STUDY_SECTION: SBCB

STUDY_SECTION_NAME: Synthetic and Biological Chemistry B Study Section[SBCB]


NIH_SPENDING_CATS: Chronic Obstructive Pulmonary Disease;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Services;Lung;Rehabilitation

PHR: Project Narrative Chronic Obstructive Pulmonary Disease is a noncommunicable disease responsible for being the 3rd leading cause of death globally, highlighting the need for interventions to address this issue. Pulmonary Rehabilitation is one proven intervention that has improved the trajectory of patient health outcomes; however, it is also currently severely underutilized. In this study, we aim to identify and implement evidence-based care components of a COPD discharge care bundle, including referrals to pulmonary rehabilitation for patients in a large hospital healthcare system to improve patient health outcomes and increase utilization rates of pulmonary rehabilitation services.

PI_NAMEs: THAKUR, NEETA  (contact)

PROGRAM_OFFICER_NAME: LU, QING

PROJECT_TERMS: Acute;Address;Awareness;Biometry;care delivery;care outcomes;career;Caring;Cause of Death;Chronic Obstructive Pulmonary Disease;Clinical Data;Clinical Research;cognitive skill;Death Rate;design;Disease;Economic Burden;Effectiveness;evidence base;Fellowship;Foundations;Goals;Guidelines;Health;Healthcare Systems;hospital readmission;Hospitals;implementation science;improved;Individual;Interruption;Intervention;matriculation;medical schools;National Heart, Lung, and Blood Institute;Outcome;parent grant;Patients;programs;Provider;pulmonary rehabilitation;Quality of life;readmission rates;Recommendation;rehabilitation service;Research;Research Personnel;Research Project Grants;Series;skills;Standardization;system-level barriers;Technical Expertise;Time

PROJECT_TITLE: Addressing System-level Barriers to COPD Guideline Concordant Care

STUDY_SECTION: SIHH

STUDY_SECTION_NAME: Science of Implementation in Health and Healthcare Study Section[SIHH]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cardiovascular;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Heart Disease - Coronary Heart Disease;Human Genome;Mental Health;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_DEPT: PSYCHIATRY

PHR: Project Narrative The proposed research is relevant to public health as it is expected to identify novel epigenetic predictors and actionable molecular targets of stress and discrimination-associated coronary heart disease (CHD), thereby opening new horizons toward personalized interventions for minoritized high-risk individuals. These expected contributions are relevant to NHLBI’s mission as they have the potential to enhance personalized prevention and treatment and close the gap of health disparities in cardiovascular disease.

PI_NAMEs: ZANNAS, ANTHONY S. (contact)

PROGRAM_OFFICER_NAME: YAN, YE

PROJECT_TERMS: Address;Affect;African American;Age;Alcohol consumption;Atherosclerosis;Biological Response Modifiers;Black Populations;Blood Cells;Body mass index;Cardiovascular Diseases;Cause of Death;Cell model;Cell Physiology;cell type;Cells;Chemicals;cohort;Complex;Computing Methodologies;Coronary heart disease;Data;Discrimination;disease disparity;Disease Outcome;disorder risk;Disparity population;DNA;DNA Methylation;Environment;Environmental Exposure;Environmental Risk Factor;Epigenetic Process;epigenome;epigenomics;Ethnic Origin;Ethnic Population;European ancestry;Exhibits;Exposure to;FOXP1 gene;Genes;Genetic;Genetic Code;Genomics;Goals;Health;health disparity;heart disease prevention;heart disease risk;high risk;high risk population;Hormones;Human;Immune;immune function;Individual;individualized prevention;Inflammation;Inflammatory;innovation;insight;Investigation;Jackson Heart Study;Knowledge;Link;Macrophage;Methylation;methylation pattern;methylomics;Minority;Minority Groups;minority stress;Mission;Modification;Molecular;Molecular Target;monocyte;Multi-Ethnic Study of Atherosclerosis;National Heart, Lung, and Blood Institute;novel;Outcome;parent grant;Participant;Pathogenesis;Pattern;peripheral blood;personalized intervention;personalized medicine;Phenotype;Physiological;Population Group;predictive modeling;prevent;Prevention;Process;programs;Psychosocial Stress;Public Health;Race;racial population;Research;Risk;Risk Factors;Role;sex;Shapes;Signal Transduction;Site;Smoking;socioeconomics;Stress;systemic inflammatory response;Testing;therapeutic target;TNF gene;Trans-Omics for Precision Medicine;United States;Whole Blood;Women's Health;Work

PROJECT_TITLE: Epigenetic mechanisms linking discrimination stress with coronary heart disease in minoritized individuals


ADMINISTERING_IC: DA

ED_INST_TYPE: GRADUATE SCHOOLS

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Methamphetamine;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Stimulant Use and Misuse;Substance Misuse

ORG_NAME: GRADUATE SCHOOL OF PUBLIC HEALTH AND HEALTH POLICY

PHR: NARRATIVE This R21 proposal addresses a critical gap in HIV prevention by assessing acceptable and preferred strategies to optimize long-acting injectable (LAI) PrEP implementation for sexual minority men (SMM) who use methamphetamine (meth). The goal will be achieved by: 1) identifying modifiable care options for LAI PrEP use through qualitative interviews with SMM who use meth and healthcare providers, and 2) determining preferred choices for LAI PrEP care delivery using a large Discrete Choice Experiment (DCE) with a diverse group of SMM who use meth.

PI_NAMEs: GROV, CHRISTIAN  (contact);PATEL, VIRAJ V

PROGRAM_OFFICER_NAME: JENKINS, RICHARD A

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;Affect;Affordable Care Act;AIDS prevention;Architecture;Behavioral;Black race;care delivery;care preference;Caring;Clinic;cohort;Computer Assisted;Computer software;cost;Data;demographics;Development;Effectiveness;Ensure;Epidemic;Ethnic Origin;Exercise;experience;experimental study;Face;Familiarity;Future;Goals;health care settings;Health Personnel;HIV;HIV risk;HIV Seronegativity;HIV Seropositivity;implementation strategy;improved;Incidence;Injectable;Injecting drug user;Injections;insight;Intervention Studies;Interview;Latinx;Literature;Maintenance;men who have sex with men;Methamphetamine;methamphetamine use;Methods;Modality;Modeling;novel strategies;Oral;Participant;Patient Recruitments;people of color;Phase;pilot test;Population;Positioning Attribute;pre-exposure prophylaxis;preference;Prevention;Prevention strategy;Primary Care;Principal Investigator;programs;Provider;Qualitative Research;Race;Recommendation;Reporting;Research;Research Methodology;Resources;response;Risk;Risk Behaviors;Rural;Sampling;sexual minority group;sexual minority men;skills;social;social stigma;stimulant use;Subgroup;substance use;success;Surveys;System;Testing;United States Preventative Services Task Force;uptake

PROJECT_TITLE: Optimizing long-acting injectable PrEP strategies for sexual minority men who use methamphetamine

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CCHI-C (02)]


NIH_SPENDING_CATS: Biotechnology;Genetics

PHR: Project Narrative This proposal provides justification for the additional funds requested to support the purchase of a Fynch Bio eVOLVER high throughput continuous culture device. This equipment will benefit our research by expanding our directed evolution toolbox to next generation techniques that rely on continuous hypermutation in continuous culture. Given that directed evolution campaigns are the rate-limiting step for the majority of the projects described in this grant, this equipment will have a significant impact on our productivity and success.

PI_NAMEs: SCHULTZ, PETER G (contact)

PROGRAM_OFFICER_NAME: SIMONOVIC, MILJAN

PROJECT_TERMS: Acceleration;Biology;Chemistry;Devices;direct application;Directed Molecular Evolution;Enzymes;Equipment;Escherichia coli;Evolution;Funding;Genes;Genetic Code;Grant;interest;Life;microbial;next generation;Peptide Hydrolases;Process;Productivity;reconstitution;Research;success;synthetic biology;System;Techniques;Therapeutic;Transfer RNA

PROJECT_TITLE: Synthesis at the Interface of Chemistry and Biology


ORG_CITY: PASADENA

ORG_NAME: CALIFORNIA INSTITUTE OF TECHNOLOGY

PHR: PROJECT NARRATIVE Our funded T-R01 project will generate a global map of in vitro interactions among >2200 human cell surface proteins and secreted ligands and map the functional consequence of these proteins on primary human immune and nervous system cells, both as individual proteins and in combinations of proteins. We request a high capacity cell culture shaking incubator that is necessary to produce these thousands of proteins, as well as hundreds of proteins of interest that will be produced on an ongoing basis for the remainder of the project.

PI_NAMEs: GARCIA, KENAN CHRISTOPHER;THOMSON, MATTHEW W.;ZINN, KAI G (contact)

PROGRAM_OFFICER_NAME: YEH, ALVIN TIEN-WEI

PROJECT_TERMS: 3-Dimensional;Address;Affinity;analysis pipeline;arm;Automation;Avidity;Bar Codes;Binding;Biological Assay;Cartilage;Cell Culture Techniques;Cell membrane;Cell surface;Cell Surface Proteins;Cell Surface Receptors;Cells;Cellular Assay;Computer software;cost;cost effective;Coupled;design;Devices;Diameter;dimer;Dimerization;DNA sequencing;Dyes;Ensure;Equipment;Exhibits;experimental study;Extracellular Domain;Flow Cytometry;Freezing;Funding;gene synthesis;Goals;Human;IgG1;Image;imaging system;Immune system;In Vitro;Incubated;Incubators;Individual;instrument;interest;Lasers;Libraries;Ligands;Liquid substance;Maps;Mediating;Methods;multiplex assay;nanoparticle;Nervous System;Orphan;parent grant;parent project;Plasmids;Process;Production;protein purification;Protein Secretion;Proteins;Rapid screening;Reader;response;Robot;Robotics;screening;single cell mRNA sequencing;Speed;success;Suspensions;Technology;Testing;transcriptomics;Transfection;tv watching;Western Blotting

PROJECT_TITLE: A Global Map of Interactions Among Human Cell Surface Proteins and Secreted Ligands

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(70)-R]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Opioid Misuse and Addiction;Opioids;Social Determinants of Health;Substance Misuse

ORG_CITY: MARQUETTE

ORG_DEPT: PSYCHOLOGY

ORG_NAME: NORTHERN MICHIGAN UNIVERSITY

ORG_STATE: MI

PHR: PROJECT NARRATIVE Poverty and opioid addiction are interrelated and chronic problems which have not been addressed adequately. This Stage III application seeks to develop and evaluate a Therapeutic Workplace that community treatment programs can implement and that arranges low-cost abstinence-contingent wage supplements to maintain drug abstinence and employment. If low-cost abstinence-contingent wage supplements in the community Therapeutic Workplace maintain drug abstinence and employment and decrease poverty, community drug-abuse treatment clinics could apply this intervention widely as a long-term maintenance treatment for unemployed adults with opioid use disorder.

PI_NAMEs: TOEGEL, FORREST JAMES (contact)

PROGRAM_OFFICER_NAME: SU, SHELLEY

PROJECT_TERMS: Abstinence;Address;Adult;base;Buprenorphine;buprenorphine treatment;Chronic;Clinic;Cocaine;common treatment;Communities;community clinic;contingency management;cost;drug abstinence;Drug abuse;Drug usage;effective therapy;effectiveness evaluation;Employment;Exclusion;food insecurity;Health Services;Hour;improved;Intervention;Maintenance;Measures;Mental Depression;Methadone;methadone treatment;Modification;Nature;Opiate Addiction;Opioid;opioid overdose;opioid use disorder;Outcome Measure;Participant;Patients;Persons;Pharmaceutical Preparations;Poverty;poverty reduction;primary outcome;Psychological reinforcement;psychosocial;Randomized;randomized, controlled study;real world application;relapse prevention;Risk;Sampling;Specialist;Therapeutic;Therapeutic community technique;treatment as usual;treatment program;Unemployment;Urine;Wages;Work;Workplace

PROJECT_TITLE: Long-Term Treatment of Opioid Use Disorder

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics;Neurosciences

ORG_DEPT: OPHTHALMOLOGY

PHR: PROJECT NARRATIVE The modern rise in myopia has received a lot of attention and is of a major concern because myopic individuals with abnormally elongated eye are at risk of developing irreversible blinding diseases including retinal detachment, macular degeneration, and glaucoma. Thus, there is an urgent unmet public health need for interventions aimed at controlling abnormal growth of the eye and thereby, preventing or slowing progression of myopia. We will utilize myopic animal models to determine factors that control eye's growth, which will guide us to identify new therapeutic targets to manage myopia.

PI_NAMEs: NAIR, KAYARAT SAIDAS  (contact)

PROGRAM_OFFICER_NAME: WIGGS, CHERI

PROJECT_TERMS: Acceleration;Affect;Agonist;Animal Model;Attention;beta catenin;Biochemical;Blindness;Callithrix;Cell Culture Techniques;Cell Physiology;cell type;Clinical;conditional mutant;Cues;Defect;Deletion Mutation;Dependovirus;deprivation;Development;Disease;emmetropization;experimental study;Extracellular Matrix;Eye;falls;Gene Targeting;Genetic;genetic approach;Genetic Processes;Genetic study;Glaucoma;Goals;Growth;Human;Hyperopia;Image;Individual;insight;Intervention;Intrinsic drive;Investigation;Length;lens;lens induction;Link;Macular degeneration;Mediating;Mediator;Messenger RNA;Microphthalmos;Modernization;Molecular;mouse model;Muller's cell;Mus;Mutant Strains Mice;Mutation;Myopia;new therapeutic target;Optics;overexpression;Pathogenesis;Pathway interactions;postnatal;postnatal development;prenatal;Prevalence;prevent;Process;programs;Proteomics;Public Health;Refractive Errors;Regulation;response;Retina;Retinal Detachment;Risk;Role;Sclera;Series;Serine Protease;Serine Proteinase Inhibitors;Signal Transduction;Structure of retinal pigment epithelium;targeted treatment;Testing;therapeutic target;Time;Transgenic Organisms;Translating;trypsin-like serine protease;Variant;Vision;Visual;WNT Signaling Pathway

PROJECT_TITLE: Characterizing the Molecular Mechanisms of PRSS56-Dependent Ocular Growth and Refractive Error

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: Los Angeles

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Project Narrative. The overarching goal of this supplement will be to learn what is the best way of understanding how inequality accumulates over the life course for underrepresented groups. A possible outcome is that we will identify specific groups and communities that need different interview modes and different content to supplement or cross validate what is being collected in the main web based UAS.

PI_NAMEs: KAPTEYN, ARIE  (contact)

PROGRAM_OFFICER_NAME: KARRAKER, AMELIA WILKES

PROJECT_TERMS: Address;Asian population;Attitude;Behavior;Black Populations;Caring;Categories;Clinical;cognitive testing;Communication;Communities;Complex;Cultural Sensitivity;Data Collection;Decision Making;Dedications;Discrimination;Disparity population;distrust;Enrollment;Ensure;ethnic minority;Ethnic Population;financial incentive;financial literacy;Focus Groups;Frequencies;General Population;Goals;Government;Grant;Health;health determinants;health disparity;Hispanic Populations;Human;improved;Individual;Inequality;interest;Interview;Knowledge;Learning;Life Cycle Stages;literacy;Literature;marginalized community;marginalized population;mathematical ability;Measures;Minority Groups;Modality;neighborhood disadvantage;Online Systems;Outcome;Participant;Perception;Personal Satisfaction;Policies;Population;population survey;Process;Questionnaires;racial minority;racial population;recruit;Research;Research Personnel;Respondent;Rural;Rural Population;Sampling;Science;Self Administration;Self Direction;social;social health determinants;Socioeconomic Status;Source;Standardization;Structural Racism;Surveys;Testing;Time;Trust;Underrepresented Populations;web-based intervention

PROJECT_TITLE: Enhancing engagement and participation of marginalized community residents in the UAS

STUDY_SECTION: SSPB

STUDY_SECTION_NAME: Social Sciences and Population Studies B Study Section[SSPB]


NIH_SPENDING_CATS: Bioengineering

ORG_CITY: MOUNTAIN VIEW

ORG_NAME: SETI INSTITUTE

PHR: Project Narrative – 2024 Equipment Supplement  The element iron plays an enormous role in biology, and we plan to study how iron contributes to catalysis (in hydrogenases) and to pH and small molecule sensing (in NEET proteins). Using very bright x-ray beams from synchrotron radiation sources, and bright infrared beams from NdYAG and quantum cascade lasers, we will study the vibrations of iron in the above systems, and this will provide structural information about how these proteins work. Information and insights gained from this project will help us better understand the biological chemistry of iron, so that we can learn from Nature to create a more efficient and healthier society and perhaps alleviate the damage from cancer and other diseases that occurs when some of these enzymes fail.

PI_NAMEs: CRAMER, STEPHEN P. (contact)

PROJECT_TITLE: Spectroscopy of Fe-S Cluster Proteins -- Information for Structure and Function - A Cryocooler Equipment Supplement


NIH_SPENDING_CATS: Biotechnology;Infectious Diseases;Malaria;Orphan Drug;Prevention;Rare Diseases;Vector-Borne Diseases

ORG_CITY: STANFORD

ORG_DEPT: PEDIATRICS

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE Plasmodium falciparum malaria remains a major public health problem globally, and new approaches to malaria control and prevention are urgently needed. In this proposal we will comprehensively determine the function of two newly-discovered human red blood cell host factors for malaria, testing the hypothesis that they facilitate parasite invasion through distinct yet synergistic pathways that are critical for the parasite’s life cycle. This project will advance our fundamental understanding of red blood cell-parasite interactions, and lay the groundwork for the development of host- directed therapies for malaria.

PI_NAMEs: EGAN, ELIZABETH S. (contact)

PROGRAM_OFFICER_NAME: QASBA, PANKAJ

PROJECT_TERMS: Avidity;Binding;CD44 gene;Cells;Cellular biology;Cessation of life;Child;Communicable Diseases;comparative;Complex;CRISPR/Cas technology;Critical Pathways;Data;Dependence;Development;DNA;Drug resistance;Erythrocytes;Experimental Genetics;Falciparum Malaria;Genetic Screening;Hematopoietic stem cells;Human;Individual;insight;Integration Host Factors;Invaded;Knowledge;Label;Life Cycle Stages;Ligands;live cell imaging;Malaria;Methods;Microscopy;Morbidity - disease rate;mortality;mutant;new therapeutic target;novel;novel strategies;novel therapeutics;novel vaccines;obligate intracellular parasite;parasite invasion;Parasites;Plasmodium;Plasmodium falciparum;Play;Pregnant Women;Prevention;Process;Proteomics;Public Health;receptor;Role;Signal Pathway;Signal Transduction;Source;Surface;Testing;Vaccines;Work

PROJECT_TITLE: Elucidating the functions of red blood cell factors in malaria parasite invasion

STUDY_SECTION: PTHE

STUDY_SECTION_NAME: Pathogenic Eukaryotes Study Section[PTHE]


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Liver Disease;Precision Medicine

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE OF PARENT GRANT The proposed research is relevant to public health because identifying the molecular mechanisms by which ceramide inactivates human hepatic stellate cells and ameliorates fibrosis will enhance our understanding of fibrogenesis and improve our ability to halt disease progression among patients with chronic liver disease. Thus, the proposed project is relevant to the NIH’s mission to seek and apply knowledge to lengthen life and reduce illness.

PI_NAMEs: CHEN, JENNIFER Y. (contact)

PROGRAM_OFFICER_NAME: DOO, EDWARD

PROJECT_TERMS: Ablation;Affect;American;antifibrotic treatment;Atomic Force Microscopy;attenuation;Biochemical;Biological Assay;Biological Markers;Cells;Ceramide Signaling Pathway;Ceramides;Cessation of life;Characteristics;Chronic;chronic liver disease;Clinical;clinical diagnostics;Clinical Treatment;clinically relevant;cohort;Collagen;conditional knockout;Data;Deposition;Development;Diagnosis;Diagnostic tests;Disease;disease heterogeneity;Disease Progression;effective therapy;end stage liver disease;Enzymes;Extracellular Matrix;Extracellular Matrix Degradation;FDA approved;fibrogenesis;Fibrosis;gain of function;galactosylgalactosylglucosylceramidase;Genes;genetic signature;Goals;Hepatic Fibrogenesis;Hepatic Stellate Cell;Human;Hydrolysis;improved;In Vitro;in vivo;Interstitial Collagenase;Knockout Mice;Knowledge;Life;Liver;Liver Failure;Liver Fibrosis;loss of function;Mediating;Mediator;Mission;Modeling;Modification;Molecular;non-alcoholic fatty liver disease;novel therapeutics;Outcome;parent grant;Parents;Pathway interactions;patient biomarkers;patient population;patient subsets;Patients;personalized medicine;Play;prevent;Public Health;Publishing;Regulation;Research;Resolution;response;Role;Sampling;Severities;side effect;Signal Pathway;Signal Transduction;specific biomarkers;STK11 gene;Stress;Techniques;Testing;Therapeutic;United States National Institutes of Health;Work

PROJECT_TITLE: Role of PRKC alpha in Extracellular Matrix Remodeling


FUNDING_MECHANISM: NON SBIR/STTR CONTRACTS

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PI_NAMEs: PAGE, STEPHANIE  (contact)

PROJECT_TERMS: Clinical Trials Network;Conduct Clinical Trials;Contraceptive Agents;Contraceptive methods;Future;Goals;Male Contraceptive Agents;men;Mission;National Institute of Child Health and Human Development;product development;protocol development;Protocols documentation;Site;Woman

PROJECT_TITLE: CCTN-CORE FUNCTION ACTIVITIES - SITE OF MALE CONTRACEPTIVE STUDIES - UWASH


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Health Disparities and Racial or Ethnic Minority Health Research;Immunization;Infectious Diseases;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Vaccine Related;Women's Health Research

ORG_CITY: ROCKVILLE

ORG_NAME: WESTAT, INC.

ORG_STATE: MD

PI_NAMEs: DRIVER, BARBARA  (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Adolescent;Adolescent Development;adolescent health;Adolescent Medicine Trials Network;Agreement;AIDS clinical trial group;Area;Award;Biological Assay;Brazil;care coordination;care systems;Child;Childhood;clinical center;Clinical Management;Clinical Research;clinical research site;Clinical Trials;Clinical Trials Network;Communicable Diseases;Conduct Clinical Trials;Contractor;Contracts;Country;Data Analyses;data management;Diagnostic Procedure;Epidemiology;Equipment;Ethnic Origin;Evaluation;Family;flexibility;Funding;Grant;Healthcare;HIV;HIV Infections;HIV prevention trials network;HIV vaccine;HIV Vaccine Trials Network;HIV-infected adolescents;HIV/AIDS;Human Development;Human Resources;Immunologics;improved;Infectious Diseases Research;Infrastructure;inner city;International;International Maternal Pediatric Adolescent AIDS Clinical Trials;Investigational Therapies;Laboratories;laboratory equipment;laboratory facility;Lead;Maintenance;Mediation;Medical;meetings;Methodology;minority children;Mission;Monitor;Mothers;National Institute of Allergy and Infectious Disease;National Institute of Child Health and Human Development;Natural History;operation;patient population;pediatric human immunodeficiency virus;pediatric human immunodeficiency virus infection;Performance;pharmacologic;Pharmacy facility;Prevention;Prevention strategy;programs;protocol development;Protocols documentation;quality assurance;Quality Control;racial minority;Recurrence;repository;Reproductive Health;Research;Research Activity;Research Personnel;Resources;Safety;Sampling;Security;Services;Shipping;Site;South Africa;Specific qualifier value;Specimen;Specimen Handling;System;Testing;Therapeutic;Therapeutic Research;Training;Translations;United States National Institutes of Health;vaccine trial;Woman;Work

PROJECT_TITLE: SUPPORT SERVICES FOR HIV AIDS CLINICAL TRIAL NETWORKS


NIH_SPENDING_CATS: Cancer;Genetics;Orphan Drug;Patient Safety;Precision Medicine;Rare Diseases

ORG_CITY: FREDERICK

ORG_NAME: LEIDOS BIOMEDICAL RESEARCH, INC.

PI_NAMEs: PARCHMENT, RALPH  (contact)

PROJECT_TERMS: AML/MDS;Area;Authorization documentation;biobank;Biological Assay;Biological Markers;biomarker identification;Categories;Characteristics;Clinical;Clinical Data;Clinical Protocols;Clinical Trials;Contracts;Data;data access;Data Commons;Data Files;data warehouse;Diagnostic;Disease;Division of Cancer Treatment and Diagnosis;Eligibility Determination;Enrollment;Future;Generations;Genotype;Goals;Immune;Institute of Medicine (U.S.);Laboratories;leukemia;longitudinal analysis;Molecular Profiling;Molecular Target;National Clinical Trials Network;Oncogenic;Pathway interactions;Patients;Pharmaceutical Preparations;Phenotype;Physicians;predictive signature;profiles in patients;Protocols documentation;Publications;Regulation;Relapse;Reporting;Reproducibility;Residual Neoplasm;Residual state;Resistance;resistance mechanism;response;sample collection;Selection for Treatments;Site;Specimen;Structure;Testing;Therapeutic;treatment optimization;treatment response;Vendor;Work

PROJECT_TITLE: MD NET


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: LOS ANGELES

ORG_NAME: VA GREATER LOS ANGELES HEALTHCARE SYSTEM

PHR: Narrative Within VA, among Veterans who have hypertension or diabetes, racial/ethnic minority Veterans are less likely than white Veterans to have these conditions under control. Some of the factors that can lead to poor control of these conditions may be related to the type of health care that the person receives, whereas other factors may be outside of the control of the health care system. Health care sites can sometimes deliver care in a way that will result in more patients achieving good control of their hypertension and diabetes. Our aims are to identify health care sites where there are fewer differences by race/ethnicity and by socio-economic status in the percentage of patients with good control of hypertension and diabetes, and to understand what some of the characteristics of patients, and their health care settings are that are associated with better control of these conditions.

PI_NAMEs: WASHINGTON, DONNA  (contact)

PROJECT_TERMS: Achievement;Address;Administrator;Affect;Alaska Native;American Indians;Attention;Black race;black/white disparity;Caregiver support;Caring;Characteristics;Clinical;clinical practice;cohort;contextual factors;Counseling;Data;Data Display;Data Sources;deviant;diabetes control;Diabetes Mellitus;Diagnosis;Disparity;Disparity population;disparity reduction;Electronics;ethnic disparity;ethnic minority;ethnic minority population;Ethnic Origin;evidence base;Evidence based intervention;Evidence based practice;experience;field study;gender disparity;Goals;Health;health care delivery;health care disparity;health care settings;health equity;Health Services Accessibility;Healthcare;Healthcare Systems;Hispanic;Housing;Hypertension;hypertension control;implementation barriers;implementation research;implementation strategy;improved;improved outcome;Income;Individual;Interview;Investments;Knowledge;Life Expectancy;Link;low socioeconomic status;Measures;Mediator;Medical;member;Methods;Minority;Minority Groups;Modeling;multi-racial;Native Hawaiian or Other Pacific Islander;Not Hispanic or Latino;Observational Study;Outcome;patient centered medical home;Patient-Centered Care;Patients;Performance;Persons;Policy Maker;preference;Prevalence;Primary Care;psychosocial;Quality of Care;Race;racial difference;racial disparity;racial minority;racial minority population;Research;Resources;Service delivery model;Site;social health determinants;Social Workers;sociodemographics;socioeconomic disparity;Socioeconomic Status;socioeconomics;team-based care;Time;Variant;Veterans;Vulnerable Populations;Woman;Work

PROJECT_TITLE: Mitigating Racial/Ethnic and Socio-Economic Disparities in VA Care Quality and Patient Experience

STUDY_SECTION_NAME: HSR-2 Behavioral, Social, and Cultural Determinants of Health and Care[HSR2]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Hematology;Physical Injury - Accidents and Adverse Effects

ORG_CITY: MILWAUKEE

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PI_NAMEs: LANDRUM, JILL  (contact)

PROJECT_TERMS: Acute;Adult;Angiotensin-Converting Enzyme Inhibitors;Animals;Childhood;cohort;Development;Documentation;Dose;Drug Kinetics;Ensure;experience;Exposure to;FDA approved;Hematology;Human;irradiation;Kidney Diseases;lead candidate;Licensure;Lisinopril;Organ;Pharmaceutical Preparations;pre-clinical;Radiation exposure;radiation mitigation;Radiation Pneumonitis;Radiation Toxicity;Rattus;Safety;Survivors;Toxic effect;Whole-Body Irradiation

PROJECT_TITLE: MITIGATION OF MULTI-ORGAN DELAYED EFFECTS OF ACUTE RADIATION EXPOSURE (DEARE) WITH ACE-INHIBITOR LISINOPRIL


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Depression;Mental Health;Neurosciences;Pain Research;Rehabilitation;Social Determinants of Health;Temporomandibular Muscle/Joint Disorder (TMJD)

ORG_CITY: FARMINGTON

ORG_NAME: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT

PHR: TMD-related pain is a widespread chronic pain problem, affecting not just the patient, but the family and the healthcare system at large. A treatment program that helps the patient more effectively develop coping skills can create the conditions necessary for long-term treatment success. Results from this project are expected to shed light on mechanisms of pain treatment and to translate to other chronic pain problems.

PI_NAMEs: LITT, MARK D. (contact)

PROGRAM_OFFICER_NAME: ELWOOD, WILLIAM N

PROJECT_TERMS: Accounting;Address;Adult;Affect;Aftercare;Behavioral;Chronic;chronic pain;chronic painful condition;chronic widespread pain;Cognition;Cognitive;Cognitive Therapy;coping;Coping Behavior;Coping Skills;Data;depressive symptoms;design;Development;Disease;Educational process of instructing;effective therapy;Effectiveness;Exhibits;experience;Family;Feeling;Frequencies;Goals;Healthcare Systems;Home environment;improved;in vivo;Individual;individualized medicine;information gathering;innovation;Life Style;Measurement;Measures;Mediating;Modeling;Monitor;Moods;Orofacial Pain;Outcome;Pain;Pain Disorder;Pain management;Pain Measurement;pain patient;pain symptom;Patients;personalized approach;Persons;Procedures;programs;psychosocial;Quality of life;Randomized;Records;recruit;Relaxation;Reporting;Role;Sampling;Self Efficacy;skill acquisition;skills;skills training;smartphone application;Splint Device;standard care;success;Temporomandibular Joint Disorders;Testing;Thinking;Time;Training;Translating;treatment effect;Treatment outcome;treatment program;Work

PROJECT_TITLE: Individualized Assessment and Treatment Program for TMD: Coping as a Mechanism

STUDY_SECTION: BMIO

STUDY_SECTION_NAME: Behavioral Medicine, Interventions and Outcomes Study Section[BMIO]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: Project Narrative Autism spectrum disorders is the most common, heritable, childhood-onset neuropsychiatric disorder. Understanding the genes and molecules critical for normal brain development will provide insight into the etiology of autism and related developmental brain disorders. These proposed studies will identify important genes for brain development and elucidate the functional and mechanistic role of specific genes in cortical development and physiology that can be targeted for the treatment of autism and other neurodevelopmental disorders.

PI_NAMEs: KONOPKA, GENEVIEVE  (contact)

PROGRAM_OFFICER_NAME: KISHORE, SANDEEP

PROJECT_TERMS: Acute;Affect;Anatomy;autism spectrum disorder;Automobile Driving;Behavior;Behavioral;behavioral phenotyping;Biological Assay;Brain;Brain Diseases;Bromodeoxyuridine;Cell Physiology;cell type;Cells;Childhood;Compensation;conditional knockout;Corpus striatum structure;Data;de novo mutation;Development;developmental disease;Disease;Dopamine Receptor;Electrophysiology (science);Electroporation;Embryo Loss;Etiology;experimental study;Family;FOXP1 gene;FOXP2 gene;functional genomics;functional outcomes;Gene Expression;Genes;Genetic Transcription;genomic data;Goals;Heritability;in utero;Individual;Injections;insight;Intellectual functioning disability;Interneurons;Knockout Mice;Laboratories;Language Disorders;Link;Measurement;member;migration;Molecular;Mutation;Neocortex;neocortical;Neuroanatomy;Neurodevelopmental Disorder;neuronal excitability;Neurons;neuropsychiatric disorder;Normal Cell;Ontology;Pathway interactions;Phenotype;Physiology;postnatal;progenitor;programs;Proliferating;Proteins;Publications;Publishing;Recurrence;Reversal Learning;Risk;risk variant;RNA analysis;Rodent Model;Role;Signal Pathway;Signal Transduction;single nucleus RNA-sequencing;single-cell RNA sequencing;Slice;social;Specific qualifier value;Speech;synaptic function;Synaptic Transmission;Tamoxifen;targeted treatment;Technology;Testing;Thick;Time;Tissue Harvesting;transcription factor;transcriptome sequencing;Variant;Work

PROJECT_TITLE: Foxp-regulated signaling pathways in brain development


ORG_CITY: PORTLAND

ORG_NAME: PORTLAND VA MEDICAL CENTER

PHR: The majority of patients with pancreatic cancer will experience progressive and profound loss of adipose tissue and skeletal muscle. This condition, known as cachexia, increases treatment toxicity, reduces function, and causes some 25-30% of cancer deaths. Feeding is insufficient to prevent weight loss in patients with pancreatic cancer because the tumor orchestrates changes in whole body metabolism and inflammation. Here we seek to use specimens from patients with pancreatic cancer to interrogate the cross-talk between tumor, adipose tissue, and skeletal muscle in order to validate pathways discovered using mouse models. Using a “mouse hospital” of mouse cohorts implanted in the pancreas with a number of patient-derived tumor lines and treatment with standard chemotherapy regimens, we will also test a novel anti-cachexia therapy. These studies will provide essential clinical correlative, mechanistic, and pre-clinical data for future clinical trials.

PI_NAMEs: ZIMMERS, TERESA A (contact)

PROJECT_TERMS: Activities of Daily Living;Adipocytes;Adipose tissue;Anticachexia Agent;biobank;Biological Markers;Blood;Body Composition;Body of pancreas;Body System;Body Weight decreased;Cachexia;Cancer Cachexia;Cessation of life;chemotherapy;Chemotherapy-Oncologic Procedure;Clinical;Clinical Trials;cohort;Data;Distant;experience;Fatty acid glycerol esters;feeding;Female;Future;Gene Expression;Genes;genetic signature;Hematopoietic System;Heterogeneity;Hospitals;Human;human tissue;Immune response;Implant;implantation;Individual;Inflammation;Interleukin 6 Receptor;Interleukin-6;Life;Link;Lipolysis;male;Malignant neoplasm of pancreas;Malignant Neoplasms;Mediating;Metabolism;Modeling;Molecular;molecular phenotype;Molecular Profiling;Morbidity - disease rate;morphometry;mortality;mouse model;Mus;Muscle;Muscular Atrophy;Nervous System;NF-kappa B;novel;Pancreas;pancreatic cancer patients;Pancreatic Ductal Adenocarcinoma;Pathogenesis;Pathway interactions;patient subsets;Patients;Phenotype;phenotypic data;pre-clinical;preclinical study;preservation;prevent;Process;Production;Proteomics;Resources;Rodent;Sampling;sex;Sex Differences;Signal Transduction;Skeletal Muscle;Specimen;STAT3 gene;Stress;Testing;Therapeutic;therapeutic evaluation;Tissues;trait;transcriptome sequencing;Translations;Treatment-related toxicity;tumor;Tumor Tissue;Validation;wasting;Xenograft procedure

PROJECT_TITLE: Tumor tissue crosstalk in the macroenvironment of pancreatic cancer cachexia


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Aging;Electronic Nicotine Delivery Systems;Neurodegenerative;Neurosciences;Tobacco

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: NARRATIVE E-cigarettes (e-cigs) are an increasingly attractive alternative to tobacco cigarettes, especially among younger users; however, little is known about the human health effects arising from chronic exposure to these aerosols. This study will determine the metal and aldehyde mixture composition of e-cig aerosols as a function of e-cig operating power by collecting e-cig aerosols from a device operated at three different powers (30, 40 and 50 W) and determine whether operating power is a critical determinant of brain metal accumulation, neurobehavioral toxicity and neuropathology in mice chronically exposed to e-cig aerosol. This study will also evaluate whether sex and genetic susceptibility to Parkinson’s Disease modify the neurotoxicity observed in the mice.

PI_NAMEs: HILPERT, MARKUS ;RE, DIANE BERENGERE (contact)

PROGRAM_OFFICER_NAME: TYSON, FREDERICK L

PROJECT_TERMS: Aerosols;age effect;Aldehydes;Behavioral;Brain;Chemicals;Chronic;Cigarette;Cognitive;Cognitive deficits;Copper;Data;Dependence;Deposition;Devices;Disease;disease model;Dose;e-cigarette aerosols;Electronic cigarette;electronic cigarette use;Environmental Health;Exhibits;experimental study;Exposure to;Gait abnormality;gene environment interaction;Genetic Predisposition to Disease;Health;Human;Inductively Coupled Plasma Mass Spectrometry;Inhalation;Inhalation Exposure;Intervention;Iron;Knock-in;Laboratories;Laboratory Research;Lead;Link;Liquid Chromatography;LRRK2 gene;male;Manganese;Manufacturer;Master of Science;Measures;Metal exposure;Metals;motor deficit;multidisciplinary;Mus;Mutation;Nerve Degeneration;neurobehavioral;Neurodegenerative Disorders;neuroinflammation;neuropathology;neurotoxic;neurotoxicity;Outcome;oxidative damage;parent grant;Parkinson Disease;Pathologic;Predisposition;Recommendation;Research;Risk;Role;Sampling;sex;skills;Strontium;Students;Testing;Tobacco;Toxic effect;Toxicology;Training;Universities;vaper;vaping

PROJECT_TITLE: Neurotoxic and neurodegenerative risks from chronic exposure to metal mixtures in e-cigarette aerosol

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(50)]


NIH_SPENDING_CATS: Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Prevention;Rare Diseases;Tickborne Diseases;Vaccine Related;Vector-Borne Diseases

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

PHR: PROJECT NARRATIVE: Babesia parasites are the causative agents of human babesiosis, a malaria-like illness endemic in the US and distributed worldwide. This proposal builds upon two recent discoveries in the Ben Mamoun Lab, which showed that Babesia parasites produce and export unique nanovesicles into the host environment, and that immunization with these vesicles protects from subsequent challenge with a lethal parasite isolate. The proposed studies aim to characterize the composition of these vesicles, understand how they confer immune protection and use this knowledge to develop an effective vaccine for human babesiosis.

PI_NAMEs: BEN MAMOUN, CHOUKRI  (contact);KASHANCHI, FATAH ;MOLESTINA, ROBERT

PROGRAM_OFFICER_NAME: MO, ANNIE X  Y

PROJECT_TERMS: Adjuvant;Anaplasmosis;Antigens;Apicomplexa;Applications Grants;associated symptom;Babesia;Babesiosis;Biological;Biology;Black-legged Tick;Blood Transfusion;Borrelia microti;Case Fatality Rates;Cell Culture Techniques;Cell membrane;Cells;Clinical;Communication;design;Development;diagnostic assay;Disease;Dose;Engineering;Environment;Erythrocytes;Fatal Outcome;Fluorescence;Fractionation;genetic analysis;Goals;granulocyte;Human;Immune;Immune response;Immune system;Immunity;Immunization;immunoregulation;In Vitro;Inbred C3H Mice;Individual;Infection;Injections;insight;Knowledge;Link;Lyme Disease;Macrophage;Malaria;Manuscripts;Measures;Mediating;Membrane;meter;Modeling;Molecular;Morbidity - disease rate;mortality;Mus;nanovesicle;novel;novel diagnostics;Orthologous Gene;Parasites;parasitism;pathogen;Pathogenesis;Pathologic;Pharmaceutical Preparations;Plasmodium falciparum;Play;population based;preclinical study;Predisposition;Preparation;Property;Protein Export Pathway;Protein Secretion;Proteins;Public Health;Reporting;Research;Role;Scanning Electron Microscopy;side effect;Structure;Subgroup;System;Therapeutic;tick transmission;Tick-Borne Diseases;Transfusion;Translating;translational study;transmission process;Tube;United States;vaccine development;Vaccines;vector tick;Vector-transmitted infectious disease;Vesicle;Virulence;Western Blotting

PROJECT_TITLE: Parasite-Derived Vesicles in Babesia virulence and Vaccine Development


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases;Orphan Drug;Rare Diseases;Tuberculosis

ORG_CITY: SAN FRANCISCO

PHR: PROJECT NARRATIVE We have shown that the pathogen Mycobacterium tuberculosis – the cause of tuberculosis – can adapt to antibiotics and the host environment by regulating the error rate of protein synthesis. However, how it achieves this without undergoing catastrophically high rates of error are not known. We will use biochemical, structural and kinetic approaches to understand this process, which in turn will enable development of targeted anti- virulence strategies.

PI_NAMEs: JAVID, BABAK  (contact)

PROGRAM_OFFICER_NAME: ROBINSON, RICHARD THOMAS

PROJECT_TERMS: Affect;Amino Acyl Transfer RNA;Amino Acyl-tRNA Synthetases;Aminoacylation;Aminoglycosides;antibiotic tolerance;Antibiotics;antimicrobial;Asparagine;Asparagine-Specific tRNA;Attenuated;attenuation;Bacteria;Binding;Binding Sites;Biochemical;Biology;blind;Charge;Classification;clinically relevant;Cryoelectron Microscopy;Data;Development;Discrimination;DNA Sequence Alteration;drug development;Environment;Escherichia coli;forward genetics;Future;Generations;Genetic;Genus Mycobacterium;Glutamine;Growth;Image;In Vitro;insight;Kinetics;Mediating;Methylation;Methyltransferase;Microbe;Minimum Inhibitory Concentration measurement;model organism;Modeling;Mus;mycobacterial;Mycobacterium tuberculosis;non-genetic;novel;pathogen;pathogenic bacteria;Pathway interactions;Pharmaceutical Preparations;pharmacologic;Phenotype;Predisposition;Preparation;prevent;Process;Protein Biosynthesis;Publishing;Regulation;Resistance;Ribosomal Interaction;Ribosomal RNA;Ribosomes;Runaway;single molecule;single-molecule FRET;small molecule;Source;Stress;stressor;structural biology;structural determinants;Structure;targeted treatment;Testing;therapy development;Transfer RNA;Transfer RNA Aminoacylation;Translating;translation assay;Translations;Tuberculosis;tuberculosis drugs;Virulence

PROJECT_TITLE: Regulation of mycobacterial adaptive mistranslation

STUDY_SECTION: PCMB

STUDY_SECTION_NAME: Prokaryotic Cell and Molecular Biology Study Section[PCMB]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;Infectious Diseases;Prevention;Vector-Borne Diseases

ORG_CITY: DAVIS

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Project Narrative: Animal- and vector-transmitted viruses are major human health threats, and the primary source of emerging viruses. However, current strategies to reduce or prevent these sources of transmission are inadequate. The goal of this proposal is to generate recombinant antiviral proteins with enhanced antiviral activities, define more biologically relevant promoters to express antiviral genes in mosquitoes, and to test their effectiveness against model viruses in cultured cells and transgenic mosquitoes, ultimately resulting in a new, modular strategy to reduce or prevent transmission of a broad range of virus families.

PI_NAMEs: ROTHENBURG, STEFAN  (contact)

PROGRAM_OFFICER_NAME: COSTERO-SAINT DENIS, ADRIANA

PROJECT_TERMS: Animals;arboviral disease;Arbovirus Infections;Arboviruses;Arthropods;Automobile Driving;Biological Assay;Blood;Cell Culture Techniques;Cell Line;Cells;Chikungunya virus;congenic;CRISPR/Cas technology;Culicidae;Cultured Cells;Data;Dengue Virus;Double-Stranded RNA;Double-Stranded RNA Binding Domain;Effectiveness;Emerging Communicable Diseases;emerging virus;experimental study;Family;fitness;Future;gene editing technology;Gene Expression;Generations;Genes;Genetic Transcription;Geography;Goals;Head;Health;Human;Immune response;Immunology;in vivo;Infection;Innate Immune System;innovation;Insecticides;Interruption;Knowledge;Mammals;Mediating;Methods;Midgut;Modeling;Mosquito Control;mosquito-borne;Mosquito-borne infectious disease;novel;novel strategies;Organism;Outcome;Persons;Poly I-C;Predisposition;prevent;promoter;Proteins;Recombinant Proteins;Recombinants;Reporter;Reporter Genes;Research;Resistance;Resolution;response;Ribonucleases;RNA;Salivary Glands;sensor;Site;Source;System;Testing;transcriptome sequencing;Transfection;transgene expression;Transgenic Organisms;transmission process;vector;vector control;vector mosquito;vector transmission;vector-borne;Vertebrates;Viral;Viral Genes;Viral Load result;Viral Physiology;Viral Proteins;viral transmission;Viral Vector;Virus;Virus Diseases;Virus Replication;Whole Organism;Zebrafish;Zoonoses

PROJECT_TITLE: Inhibition of virus replication by broadly-acting recombinant enhanced antiviral restrictors (REAVRs)

STUDY_SECTION: TVZ

STUDY_SECTION_NAME: Transmission of Vector-Borne and Zoonotic Diseases Study Section [TVZ]


ADMINISTERING_IC: NS

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: BOSTON

ORG_NAME: HARVARD MEDICAL SCHOOL

PI_NAMEs: KOHANE, ISAAC S. (contact)

PROGRAM_OFFICER_NAME: DOSS, ARGENIA LANISHA NECOLE

PROJECT_TERMS: Acceleration;Address;Area;Biomedical Research;Caring;Clinical;Clinical Data;Clinical Research;Collaborations;Data;Data Coordinating Center;data management;data sharing;design;Development;Diagnosis;Diagnostic;Disease;Education;Ensure;Evaluation;Evidence based practice;experience;Feedback;follow-up;Foundations;Future;Generations;genomic data;Genomics;Goals;improved;Infrastructure;innovation;Institution;Knowledge;Lead;Leadership;Medical;medical specialties;Methods;novel;operation;Outcome;Outcome Assessment;outreach;Patient Care;patient engagement;Patients;Phase;Process;process improvement;programs;Protocols documentation;Provider;Public Relations;rare condition;Rare Diseases;recruit;Reporting;Research;Research Support;Science;success;Technology;web platform;Work

PROJECT_TITLE: Administrative Core


ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: YORK

ORG_NAME: ASSOCIATION OF FOOD AND DRUG OFFICIALS

ORG_STATE: PA

PHR: PROJECT NARRATVE This Association of Food and Drug Officials (AFDO) project entitled Funding System to Support Milk and Shellfish Regulatory Programs, Years 4-8 is intended to facilitate long- term improvements to the national food safety system by assisting state and territorial (ST) milk and shellfish regulatory programs by: • Communicating effectively, in coordination with all relevant partners, regarding the available  FDA funding opportunities that support milk and shellfish programs, assuring that all eligible  jurisdictions are equally aware of the opportunities; and • Providing FDA subaward funding to qualified milk and shellfish regulatory agencies in a fair  and equitable manner, enabling them to attend FDA-approved training courses and/or  acquire necessary equipment that will improve public health outcomes. These goals will significantly advance a National Integrated Food Safety System and effectively fulfill the partnership requirements of the Food Safety Modernization Act (FSMA).

PI_NAMEs: MANDERNACH, STEVEN  (contact)

PROGRAM_OFFICER_NAME: BUTLER, JENICE