NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: NEW YORK

ORG_NAME: ROCKEFELLER UNIVERSITY

ORG_STATE: NY

PHR: Project Narrative. Alzheimer's Disease (AD) and AD-related dementias (ADRDs) are crippling neurodegenerative disorders whose onset strongly correlates with aging. There are compelling reasons to believe cellular senescence (effectively, cell aging) and retrotransposons (selfish DNA) may drive or exacerbate AD and ADRDs by inducing a state of chronic stress (inflammation); more research is needed. We will analyze the role of LINE-1 retrotransposons in senescent cells and Alzheimer's / ADRD afflicted brain tissues, gathering additional evidence to support or refute the hypothesis that LINE-1 is a causal agent in Alzheimer's / ADRD.

PI_NAMEs: LACAVA, JOHN  (contact);SEDIVY, JOHN M

PROGRAM_OFFICER_NAME: YAO, ALISON Q

PROJECT_TERMS: Age;age related neurodegeneration;age-related disease;Aging;aging population;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease related dementia;Astrocytes;Autopsy;Biological;Biological Assay;Biological Models;Brain;brain tissue;candidate selection;Cause of Death;Cell Aging;Cell Culture Techniques;Cell Nucleus;Cells;Cerebrospinal Fluid;Chromosomal Instability;Chronic stress;Clinical;cytokine;Cytoplasm;Cytoplasmic Granules;Cytosol;Data;derepression;Detection;Deterioration;Disease;DNA;DNA Damage;DNA replication fork;Double-Stranded RNA;Elderly;Endogenous Retroviruses;endonuclease;Enzymes;Exhibits;Fibroblasts;fly;Freezing;Frontotemporal Dementia;Functional disorder;Genes;Genome;genome integrity;Genomics;Growth Factor;Homeostasis;Human;Hybrids;Immunity;immunogenic;Immunoprecipitation;Impaired cognition;improved;In Vitro;Individual;Induced pluripotent stem cell derived neurons;Inflammation;Inflammatory;Integration Host Factors;Interferons;Knowledge;Label;Lewy Body Dementia;Life;Life Cycle Stages;Location;Mass Spectrum Analysis;Modeling;Molecular;Molecular Genetics;Motivation;Mus;Neurodegenerative Disorders;normal aging;Normal Cell;Nucleic Acids;Onset of illness;overexpression;Parasites;Pathologic;pathological aging;Pathology;Pathway interactions;Patients;Phase;Phenotype;Physiological;Play;prevent;Production;Property;protein expression;Proteins;Reactive Oxygen Species;Research;Retrotransposon;Ribonucleoproteins;RNA;RNA Interference;RNA-Directed DNA Polymerase;RNA-Protein Interaction;Role;Sampling;Selfish DNA;senescence;senescence associated secretory phenotype;senescent cell;Shotguns;Source;System;tau Proteins;Techniques;Tissues;Titrations

PROJECT_TITLE: Defining molecular contributions of LINE-1 retrotransposons to AD / ADRD


ADMINISTERING_IC: LM

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Cerebrovascular;Dementia;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Stroke;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: BOSTON

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: We will develop a novel clinical informatics approach to assist clinicians as they diagnose and treat a number of brain diseases. Our aim is to model, analyze, and quantify brain blood vessels to improve accuracy and sensitivity during detection of cerebrovascular diseases (CVDs), such as intracranial aneurysms, intracranial vascular stenosis, vasculitis, and vasospasm. As CVDs affect a large population each year and cause high rates of morbidity and mortality, the proposed project will lead to a computer-aided detection tool for clinicians to use as they interpret cerebral angiography to benefit patients.

PI_NAMEs: YOUNG, GEOFFREY  (contact)

PROGRAM_OFFICER_NAME: REDDY, GOUTHAM

PROJECT_TERMS: 3-Dimensional;accurate diagnosis;Address;Adoption;Affect;Algorithms;Angiography;Arteries;Back;Blood Vessels;Brain;Brain Aneurysms;Brain Diseases;Brain hemorrhage;Brain imaging;Brain scan;Cause of Death;Centers for Disease Control and Prevention (U.S.);Cerebral Angiography;cerebrovascular;Cerebrovascular Disorders;Cerebrovascular system;Cessation of life;Classification;Clinic;Clinical;clinical diagnosis;clinical imaging;Clinical Informatics;Coagulation Process;Color;Complex;Computational algorithm;Computational Technique;computer aided detection;Computer Assisted;computerized;Computers;Consumption;deep learning;deep learning model;design;Detection;Diagnosis;Diagnostic;Disease;disease diagnosis;Fatigue;Fistula;Goals;Health;Hemorrhage;Human;Image;image processing;imaging modality;imaging Segmentation;improved;Individual;Informatics;Interobserver Variability;Intracranial Aneurysm;Knowledge;Location;malformation;Manuals;Measurement;Measures;Methods;Modeling;Morbidity - disease rate;mortality;Nervous System Trauma;Neurosurgeon;neurosurgery;novel;open source;operation;Operative Surgical Procedures;Outcome;Paralysed;Patients;Persons;Population;Positioning Attribute;Prevalence;Preventive treatment;Process;Reader;Research;Rotation;Ruptured Aneurysm;Scanning;Scheme;Sensitivity and Specificity;shape analysis;Shapes;Source Code;Speech;statistics;Stenosis;Stroke;Surface;Symptoms;Techniques;Time;tool;Training;United States;Validation;Vasculitis;Vasospasm;Visualization;Work;X-Ray Computed Tomography

PROJECT_TITLE: A New Informatics Approach for Detection of Cerebrovascular Abnormalities

STUDY_SECTION: BLR

STUDY_SECTION_NAME: Biomedical Informatics, Library and Data Sciences Review Committee[BLR]


ADMINISTERING_IC: AI

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Bioengineering;Brain Disorders;Clinical Research;Epilepsy;Infectious Diseases;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: Framingham

ORG_NAME: KEPHERA DIAGNOSTICS, LLC

PHR: Project Narrative Epilepsy is the fourth most common neurological disorder in the U.S. and affects over 50 million people worldwide. This project addresses the critical need for a point-of-care test to diagnose Neurocysticercosis in patients with epileptic seizures, as this parasitic infection is responsible for about one third of all epilepsy and is the major cause of adult epilepsy worldwide. In Phase II we will refine this assay into a manufactured product, carry out a validation study to support a de novo submission to FDA, and prepare for scale up and commercial launch of the assay.

PI_NAMEs: LEVIN, ANDREW E. (contact)

PROGRAM_OFFICER_NAME: JOY, DEIRDRE A

PROJECT_TERMS: Address;Adult;Affect;Anthelmintics;antibody detection;Antigens;Antiparasitic Agents;Biological Assay;Brain;Brain Diseases;Buffers;Chemistry;Clinical;clinical diagnosis;Clinical Research;clinical research site;commercial launch;Complex;cost;Country;Cyst;design;detection sensitivity;Development;Diagnosis;Diagnostic;Diagnostic tests;diagnostic tool;Disease;effective therapy;Electroencephalography;Ensure;Enzyme-Linked Immunosorbent Assay;Enzymes;Epilepsy;Etiology;Europe;Family suidae;FDA approved;Frequencies;Goals;Gold Colloid;Human;Hygiene;Image;imaging study;Immigration;Immunoassay;in-vitro diagnostics;Income;Individual;Infection;infection rate;Infrastructure;Label;Laboratories;Lateral;lateral flow assay;Location;Magnetic Resonance Imaging;manufacture;manufacturing scale-up;Measurement;Measures;medical specialties;meetings;Methods;Multi-site clinical study;Nervous System Disorder;nervous system infection;neural;Neurocysticercosis;Neurologic;Neurologic Symptoms;Parasitic Diseases;Parasitic infection;patient screening;Patients;Performance;Persons;Phase;point of care;point of care testing;Preparation;Price;Procedures;prospective;Prospective Studies;prototype;Reagent;Recombinants;Reference Standards;Reflex action;research clinical testing;Resistance;Retrospective Studies;Sampling;scale up;Seizures;Sensitivity and Specificity;Serology test;Serum;skills;Specificity;statistics;Structural defect;Symptoms;Taenia solium;Temperature;Testing;Tissues;tool;Training;Travel;validation studies;Western Blotting;Whole Blood;World Health Organization

PROJECT_TITLE: Rapid Point-of-Care Assay for Diagnosis of Neurocysticercosis in Seizure Patients

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DCAI-E(13)]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: Chicago

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: The proposed research is directly relevant to public health and aligned with the NIA’s mission because it addresses molecular patho-mechanisms underlying endo-lysosome dysfunction in Alzheimer’s disease and the contribution of this dysfunction to the development of amyloid plaque pathology. Based on our novel mechanistic hypotheses, which are directly relevant to development of therapeutic strategies, our proposed work utilizes a range of current techniques (including use of an iPSC model and proteomics on isolated axons) to determine the molecular mechanism by which the adaptor protein complex, AP-4, regulates axonal autophagic, lysosomal transport and maturation, and protects neurons from amyloidogenic pathways. Outcomes from our proposal are expected to fully serve the NIA’s mission by aiding in development of therapeutic strategies for Alzheimer’s disease and by providing novel mechanistic insight into other age-related neurodegenerative diseases known to have a lysosomal component to their pathology.

PI_NAMEs: GOWRISHANKAR, SWETHA  (contact)

PROGRAM_OFFICER_NAME: FENG, LI REBEKAH

PROJECT_TERMS: Abeta synthesis;Adaptor Signaling Protein;Address;Age;age related;age related neurodegeneration;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease risk;Amyloid beta-Protein;Amyloid beta-Protein Precursor;amyloid precursor protein processing;Autophagocytosis;Autophagosome;Axon;beta-site APP cleaving enzyme 1;Binding Proteins;Biogenesis;Biology;Brain;brain tissue;cell type;Cells;Cellular biology;Complex;Coupled;Data;Defect;Deposition;Development;Disease;Dynein ATPase;Event;Exhibits;experimental study;extracellular;Frontotemporal Dementia;Functional disorder;Genes;Genetic;Genotype;Hereditary Spastic Paraplegia;Homeostasis;Human;Image;Immunofluorescence Immunologic;Immunoprecipitation;Impairment;in vivo;induced pluripotent stem cell;Induced pluripotent stem cell derived neurons;insight;interdisciplinary approach;Knockout Mice;Knowledge;Link;loss of function;Lysosomes;Mediating;Membrane Proteins;Metabolism;misfolded protein;Mission;Modeling;Molecular;mouse model;Mus;Neurodegenerative Disorders;Neurons;novel;novel therapeutics;Organelles;Outcome;Parkinson Disease;Pathogenesis;Pathogenicity;Pathologic;Pathology;Pathway interactions;Pattern;Peptides;Phenocopy;Prefrontal Cortex;presenilin-2;Process;Production;protein complex;Proteins;Proteolytic Processing;Proteomics;Public Health;Reelin Signaling Pathway;Research;Role;secretase;Senile Plaques;Site;sortilin;Sorting;superresolution microscopy;Swelling;Synapses;Techniques;Testing;Therapeutic;therapeutic development;Therapeutic Intervention;therapeutically effective;tool;trafficking;trans-Golgi Network;Transgenic Mice;Vesicle;Wild Type Mouse;Work

PROJECT_TITLE: Elucidating the role of Adaptor Protein complex-4 in regulating axonal autophagic and lysosomal pathways

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


ADMINISTERING_IC: AT

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Biotechnology;Complementary and Integrative Health;Genetics;Human Genome;Natural Products

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: NORTHWESTERN UNIVERSITY

PHR: Project Narrative  The proposed research will significantly advance public health by advancing technical approaches that will greatly expand access to the repertoire of biologically active natural products (NPs) produced by fungi. These compounds have served as the basis for many clinically used medicines today, but their rate of discovery can be sharply accelerated. The approaches and topics developed in this research will help reinvigorate the fungal NP discovery pipeline, improving access to new medicines in the future.

PI_NAMEs: KELLEHER, NEIL L (contact);KELLER, NANCY P

PROGRAM_OFFICER_NAME: STILL, PATRICK COLBY

PROJECT_TERMS: Acceleration;Accounting;Actinobacteria class;Address;Agrochemicals;anti-fungal agents;Antibiotics;Antineoplastic Agents;Antiparasitic Agents;Ascomycota;Aspergillus nidulans;Bacteria;bioactive natural products;Bioinformatics;Biological;Caspofungin;Cells;Chemicals;Chromosomes;Clinical;Cloning;Collaborations;Collection;Cyclosporins;Data;Data Set;economic value;Euchromatin;Funding;Fungal Genome;Fungal natural products;fungus;Future;Gene Cluster;Generations;Genes;Genetic;Genome;genome sequencing;Genomic approach;genomic locus;Genomics;Genotype;Goals;Histones;Hot Spot;Immune;immunoregulation;Improve Access;improved;Inflammatory Response;insight;Link;Lovastatin;Maps;Mass Spectrum Analysis;Medicine;member;Metabolism;metabolomics;Methodology;Methods;migration;Modeling;Molecular Biology;Natural product discovery;Natural Products;neutrophil;new technology;novel;Output;overexpression;Pathway interactions;Penicillins;permissiveness;Phenotype;Production;Proteins;Public Health;Reader;Recording of previous events;Reporter;Research;response;screening;screening program;secondary metabolite;Secure;Soil;Source;Sterigmatocystin;Structure;success;Surveys;Technology;Tertiary Protein Structure;Testing;Therapeutic;Time;tool;Viral;Work;Zebrafish

PROJECT_TITLE: Mapping and Understanding Production of Natural Products in Fungi

STUDY_SECTION: EBIT

STUDY_SECTION_NAME: Enabling Bioanalytical and Imaging Technologies Study Section[EBIT]


ADMINISTERING_IC: MD

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: CORAL GABLES

ORG_NAME: UNIVERSITY OF MIAMI CORAL GABLES

ORG_STATE: FL

PHR: PROJECT NARRATIVE This study will evaluate the effects of a parenting intervention for Hispanic sexual minority youth in preventing/reducing drug use and depressive symptoms. It will also examine whether the intervention improves parent social support for the adolescent, parent acceptance, family functioning, and whether it reduces general stress and stress associated with being a Hispanic sexual minority. The knowledge expected to be gained from this study has the potential to transform the type of prevention programs that are disseminated to communities to improve the health of Hispanic sexual minority youth.

PI_NAMEs: PRADO, GUILLERMO  (contact)

PROGRAM_OFFICER_NAME: BARKSDALE, CRYSTAL

PROJECT_TERMS: acceptability and feasibility;Address;Adolescent;adolescent drug use;Advocate;Affect;arm;Communication;Communities;Community Practice;COVID-19;cultural values;Data;depressive symptoms;design;Development;Disclosure;Discrimination;drug abuse prevention;Drug Targeting;Drug usage;efficacy evaluation;evidence base;experience;Face;Family;family support;Frequencies;Gender;gender difference;Goals;Group Processes;Health;Health Promotion;Heterogeneity;Heterosexuals;high risk;Hispanic;Hispanic Populations;Homophobia;improved;Individual;Intervention;intervention effect;Knowledge;Learning;Libido;Mediating;Mental Depression;minority stressor;Not Hispanic or Latino;Outcome;parent-adolescent communication;parental involvement;parenting intervention;Parents;peer;Peer Pressure;Pharmaceutical Preparations;Pilot Projects;pilot test;prevent;Prevention program;preventive intervention;Process;psychologic;Publishing;racism;Randomized;Randomized, Controlled Trials;Reaction;Reporting;resilience;Risk;Risk Behaviors;Risk Reduction;Role;sexual minority;sexual minority stress;sexual minority youth;skills;Social support;standard of care;Stress;stress management;syndemic;trial design;Work;Youth

PROJECT_TITLE: Promoting Health and Reducing Risk among Hispanic Sexual Minority Youth and their Families

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Immunotherapy;Infectious Diseases;Orphan Drug;Prevention;Rare Diseases

ORG_CITY: ROCKVILLE

ORG_NAME: ABVACC, INC.

ORG_STATE: MD

PHR: Filoviruses are among the deadliest pathogens known to humans. The Ebola virus disease outbreak in West Africa (2014-2016), caused by the Zaire Ebola virus, resulted in over 28,000 cases and 11,000 deaths. In addition to Ebola virus, a related filovirus called Marburg has caused five outbreaks in the past 10 years with high fatality rates. This proposal is aimed at developing effective immunoprophylactic against Marburg virus for protection of first responders during outbreaks of Marburg virus disease. We have generated several antibody drug candidates that protect against Marburg infection. Under this proposal we will engineer the lead antibody to acquire long term durability after injection and we will perform animal efficacy studies. This study, if successful, will set the stage for clinical development of an effective therapeutic for human use.

PI_NAMEs: AMAN, M JAVAD (contact)

PROGRAM_OFFICER_NAME: DYALL, JULIE

PROJECT_TERMS: Acceleration;Advanced Development;Africa;African;Aman;animal efficacy;Animal Model;animal rule;Antibodies;antigen binding;Antigens;B-Lymphocytes;base;Binding;Binding Sites;Biochemical;Biological Availability;Biological Products;Biological Response Modifier Therapy;Blood Chemical Analysis;Bundibugyo virus;Case Fatality Rates;Cavia;cell bank;Cell Line;Cells;Cessation of life;chimeric antibody;Chinese Hamster Ovary Cell;clinical development;Collaborations;Country;Death Rate;Development;Disease Outbreaks;Dose;drug candidate;Drug Kinetics;Ebola;Ebola Hemorrhagic Fever;Ebola virus;efficacy evaluation;efficacy study;Engineering;Epidemic;epidemic response;Epitopes;experience;Exposure to;Family;Fatality rate;Fc domain;Filovirus;first responder;Fright;Funding;Future;Generations;Genetic;Glycoproteins;GP2 gene;GTPBP1 gene;Half-Life;Health Personnel;Health protection;Healthcare;Healthcare Systems;Hematology;hemorrhagic fever virus;high risk population;Hospital Personnel;Human;Immunity;Immunization;Immunotherapy;Infection;Injections;innovation;Lead;Left;Licensure;Liquid substance;Macaca;Macaca fascicularis;manufacture;Marburg Virus Disease;Marburgvirus;Measures;Memory B-Lymphocyte;Modeling;Monitor;Monoclonal Antibodies;Mus;mutant;Mutation;Nature;neonatal Fc receptor;neutralizing antibody;neutralizing monoclonal antibodies;nonhuman primate;novel;novel strategies;Nurses;outbreak control;pathogen;Patients;Periodicals;Persons;Phase;Physicians;pressure;Prevention;Preventive vaccine;Process;product development;Production;prophylactic;Prophylactic treatment;rational design;receptor binding;Research;Research Personnel;Resources;Risk;Safety;Serum;Services;Small Business Innovation Research Grant;Social Workers;stable cell line;success;Sudan Ebola virus;Testing;Therapeutic;Therapeutic Monoclonal Antibodies;therapeutically effective;Time;Toxicology;Transfection;Vaccinated;Variant;Viral Hemorrhagic Fevers;viral outbreak;Viremia;Virus;Work;Zaire Ebola virus

PROJECT_TITLE: Prophylactic Immunotherapy for Marburg Virus Disease Outbreak Control

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DCAI-F(12)]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Disability Research;Fragile X Syndrome;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric;Rare Diseases

ORG_CITY: MADISON

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it contributes to a program of research focused on significantly improving the communication abilities of children with language impairments, including children with fragile X syndrome and children with developmental language disorder (DLD). The proposed study will track language production and comprehension over time in school age children, considering the unique impact of one aspect of cognition (executive function). Given the prevalence of DLD (7-13% of school age children), and the significant overlap in the language phenotype between fragile X and DLD, this project addresses the NIDCD's mission to improve the lives of individuals with communication disorders.

PI_NAMEs: HOOVER, JILL ;STERLING, AUDRA MARIE (contact)

PROGRAM_OFFICER_NAME: STORKEL, HOLLY LYNN

PROJECT_TERMS: Adaptive Behaviors;Address;Affect;Area;Attention;Child;Clinical;clinical practice;Cognition;Cognitive;cognitive ability;Communication;Communication impairment;Comparative Study;Complex;Comprehension;critical period;Data;design;Development;developmental disease;Disease;Effectiveness;Ensure;Etiology;executive function;Fragile X Syndrome;Future;Growth;Impairment;improved;Individual;Inherited;innovation;Intellectual functioning disability;Intervention;Intervention Studies;Investigation;Knowledge;Language;Language Development;Language Development Disorders;Language Disorders;language impairment;Learning;Length;literacy;male;Matched Group;Measures;Methods;Mission;National Institute on Deafness and Other Communication Disorders;Parents;Pattern;peer;Performance;Phenotype;Population;Prevalence;Production;Productivity;programs;Public Health;recruit;Reporting;Research;Research Design;Sampling;School-Age Population;Short-Term Memory;skills;social;social communication;Standardization;Structure;success;System;Testing;theories;Time;virtual;Walking;Work

PROJECT_TITLE: The relationship between language and executive function in DLD and FXS over time

STUDY_SECTION: LCOM

STUDY_SECTION_NAME: Language and Communication Study Section[LCOM]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Congenital Structural Anomalies;Genetics;Infertility;Neurosciences;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Women's Health Research

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative: TRIM-NHL proteins control gene expression, development, and stem cell fate, and their dysfunction causes neurodevelopmental diseases, infertility, and cancer. We study Drosophila Brain tumor (Brat) as a model, and seek to identify its regulatory mechanisms, network of target genes, and functions in development of the brain and germline. The results will improve the understanding of TRIM-NHL biological functions and disease pathogenesis.

PI_NAMEs: GOLDSTROHM, AARON CHARLES (contact)

PROGRAM_OFFICER_NAME: VATAKIS, DIMITRIOS NIKOLAOS

PROJECT_TERMS: Adult;Affect;Animals;Binding;Binding Proteins;Binding Sites;Bioinformatics;Biological;Biological Assay;Biological Process;Brain;Brain Neoplasms;BRAT gene;Cancer Etiology;Cell Culture Techniques;Cells;Complex;Congenital Hydrocephalus;Cultured Cells;Data;Development;Developmental Process;Disease;Drosophila genus;Drosophila melanogaster;Embryonic Development;Family;fly;Functional disorder;Gene Expression;Gene Expression Regulation;gene network;Genes;Genetic;genetic corepressor;genome editing;Germ Lines;Goals;improved;in vivo;Infertility;insight;Lobular Neoplasia;Location;loss of function;Malignant Neoplasms;Maps;Measures;Mediating;member;Messenger RNA;Modeling;Molecular;mRNA Decay;mRNA Expression;mRNA Stability;mRNA Transcript Degradation;mRNA Translation;mutant;Mutate;Names;Nervous System Disorder;Neurodevelopmental Disorder;neurogenesis;Oogenesis;Pathogenesis;Pathway interactions;Poly(A) Tail;polyadenosine;Post-Transcriptional Regulation;Proliferating;protein function;Proteins;Reporter;Reporter Genes;Repression;Research;Ribonucleases;RNA;RNA Binding;RNA-Binding Proteins;Role;stem cell fate;stem cell proliferation;stem cells;stemness;Tail;Tissues;transcription factor;transcriptome;Translational Repression;Translations;translatome;TRIM Gene;TRIM Motif;Work

PROJECT_TITLE: mRNA regulatory functions of the Drosophila TRIM-NHL protein, Brat

STUDY_SECTION: MGB

STUDY_SECTION_NAME: Molecular Genetics B Study Section[MGB]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases;Rare Diseases;Tuberculosis

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: This project seeks to understand the pathways and mechanisms of DNA repair and mutagenesis in mycobacteria. These studies will both elucidate basic mechanisms of DNA repair in bacteria, but also inform our understanding of how mycobacterial pathogens, including M. tuberculosis, the causative agent of the disease tuberculosis, evolve antibiotic resistance. The long term goal of these studies is, through basic understanding of mycobacterial DNA repair pathways, to validate DNA repair as a therapeutic target for mycobacterial infections, thereby advancing efforts to control tuberculosis and other mycobacterial infections.

PI_NAMEs: GLICKMAN, MICHAEL S (contact);SHUMAN, STEWART H

PROGRAM_OFFICER_NAME: ROBINSON, RICHARD THOMAS

PROJECT_TERMS: Actinobacteria class;Adenylyl Imidodiphosphate;Affect;Antibiotic Resistance;Antimicrobial Resistance;Architecture;arm;ATP Hydrolysis;ATP phosphohydrolase;Award;Bacteria;Bacterial DNA;Binding;Biochemical;Biological Assay;Biological Models;C-terminal;Cardiolipins;Cell membrane;Cells;Cessation of life;combat;Complement;Complex;Couples;Coupling;crosslink;Cryoelectron Microscopy;Data;Disease;DNA;DNA Binding;DNA Damage;DNA Double Strand Break;DNA glycosylase;DNA Interstrand Cross-Link Repair;DNA Interstrand Crosslinking;DNA Repair;DNA Repair Enzymes;DNA Repair Pathway;Double Strand Break Repair;Drug resistance in tuberculosis;emerging antibiotic resistance;Escherichia coli;Evolution;Excision;experimental study;Family;Filament;Freezing;Funding;Genes;genetic approach;genetic manipulation;Genus Mycobacterium;Goals;Grant;Health;helicase;homologous recombination;Human;human pathogen;in vivo;Infection;insight;interest;Invaded;Knowledge;Leprosy;lipidomics;Mass Spectrum Analysis;Mechanics;melting;Membrane;Mitomycin C;Molecular Conformation;Motor;Mutagenesis;mutant;Mutation;mycobacterial;Mycobacterium Infections;Mycobacterium leprae;Mycobacterium smegmatis;Mycobacterium tuberculosis;N-terminal;novel;novel strategies;nuclease;Nucleic Acids;Nucleoproteins;pathogen;Pathogenesis;Pathway interactions;Peptide Hydrolases;Phase;Phosphatidylinositols;Phospholipids;Phosphorylation;Process;Proteins;Proteomics;Pump;Regulation;repair strategy;repaired;Resected;response;Role;Serine;single molecule;Single-Stranded DNA;Site;SOS Response;Structure;System;Tail;Testing;therapeutic target;Tuberculosis;Wit;Work

PROJECT_TITLE: Mycobacterial DNA repair and mutagenesis

STUDY_SECTION: PCMB

STUDY_SECTION_NAME: Prokaryotic Cell and Molecular Biology Study Section[PCMB]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Genetics;Kidney Disease

ORG_CITY: DALLAS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: Modified Public Health Relevance Section  Acute kidney injury is a common illness among hospitalized patients throughout the world. No drugs or other treatments exist to prevent or improve the course of this illness, and its consequences can be severe, including irreversible chronic kidney disease. This grant application proposes studies to examine how knowledge about energy metabolism might be applied in the future to treat acute kidney injury.

PI_NAMEs: PARIKH, SAMIR M (contact)

PROGRAM_OFFICER_NAME: SADUSKY, ANNA BURKART

PROJECT_TERMS: Active Biological Transport;Acute;Acute Renal Failure with Renal Papillary Necrosis;Anabolism;Applications Grants;Area;Articulation;Attenuated;Award;Biogenesis;Biology;cell injury;Cells;Chronic;Chronic Kidney Failure;Cicatrix;Clinical;cofactor;Collaborations;Data;design;Development;Drug Compounding;End stage renal failure;Energy Metabolism;Enzyme Inhibitor Drugs;Exhibits;Failure;Fibrosis;Fluid Balance;Funding;Future;Genetic Models;Health;Homeostasis;Hospitalization;Human;improved;in vivo;injured;Injury;Injury to Kidney;insight;Intervention;Kidney;Kidney Diseases;Knowledge;Laboratories;long-term sequelae;Medicine;Metabolic;Metabolism;Mitochondria;Modeling;new therapeutic target;Organelles;Outcome;Pathway interactions;Patients;Pharmaceutical Preparations;pharmacologic;Pharmacologic Substance;Phenotype;PPAR gamma;precision medicine;prevent;Prevention;Probability;Production;programs;Proteins;Public Health;public health relevance;Publications;Quality Control;Renal function;Renal tubule structure;Reperfusion Injury;Reporting;Research;research clinical testing;Resistance;Risk;Sodium;Stress;stressor;success;Testing;Therapeutic;tool;transcription factor;Transcriptional Activation;Transgenic Mice;Translations;Tubular formation;United States National Institutes of Health;Work

PROJECT_TITLE: Mitochondria and metabolism in kidney disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-W(05)]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Neurosciences;Women's Health Research

ORG_DEPT: BIOLOGY

ORG_NAME: NEW YORK UNIVERSITY

PHR: Aging and rejuvenation: An ant model to study the regulation of longevity Project narrative:  Ant colonies consist of nearly genetically identical individuals that exhibit different morphology, play distinct behavioral roles in the colony, and vary dramatically in their lifespan. In the absence of the queen, the non-reproductive workers of the ant Harpegnathos can transition into reproductive pseudo-queens (gamergates), accompanied by a five-fold extension of their lifespan and this can be fully reversed if gamergates are induced to transition back to the worker status. The extreme alteration in the degree of aging that accompanies the caste switch, combined with the experimental amenability of Harpegnathos, makes it an ideal system to characterize the molecular dynamics of aging, rejuvenation, and reproduction.

PI_NAMEs: DESPLAN, CLAUDE  (contact);REINBERG, DANNY

PROGRAM_OFFICER_NAME: GUO, MAX

PROJECT_TERMS: Adipose tissue;Affect;Age;age related changes;Aging;aging biomarker;aging mechanism;aging related;AKT inhibition;Animals;Ants;Apoptotic;Back;Bees;Behavior;Behavioral;Binding;biological age;Biological Assay;Biological Models;Brain;brain remodeling;candidate identification;Carbohydrates;Castes;cell type;Cells;Chronology;Clustered Regularly Interspaced Short Palindromic Repeats;comparative;CRISPR/Cas technology;Data;DNA Methylation;DNA Transposable Elements;Drosophila genus;egg;Epigenetic Process;Event;Exhibits;experience;Experimental Models;extend lifespan;extracellular;Fat Body;Fatty acid glycerol esters;gain of function;Gene Expression;Genes;Genetic;Genetic Transcription;Hemolymph;Immunoprecipitation;In Vitro;in vivo;Individual;Insecta;Insulin;insulin signaling;Insulin Signaling Pathway;insulin-like signaling;Investigation;knock-down;Length;life span;Lipids;Liver;Longevity;loss of function;MAP Kinase Gene;Mass Spectrum Analysis;Measures;Mediating;Metabolic;Metabolism;Microscopy;Modeling;Molecular;molecular dynamics;Morphology;mutant;Mutate;neural circuit;Neurons;Nuclear;Output;Ovary;Pathway interactions;Pattern;Pharmaceutical Preparations;pharmacologic;Phosphorylation;Physiological;Physiology;Play;potential biomarker;Production;Proliferating;Proteins;Proto-Oncogene Proteins c-akt;Regulation;Rejuvenation;Repression;Reproduction;reproductive;response;RNA Interference;Role;Signal Pathway;single cell mRNA sequencing;single-cell RNA sequencing;social;social group;Social status;Source;Surveys;synergism;System;telomere;Testing;Tissues;transcriptomics;treatment effect

STUDY_SECTION: CMAD

STUDY_SECTION_NAME: Cellular Mechanisms in Aging and Development Study Section[CMAD]


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Brain Disorders;Gene Therapy;Genetics;Immunotherapy;Multiple Sclerosis;Neurodegenerative;Neurosciences

ORG_CITY: SAINT LOUIS

ORG_DEPT: NEUROLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Treatments for autoimmune diseases such as multiple sclerosis (MS) are not selective enough to target the specific T cells responsible for driving inflammation, neurologic injury, and associated disability. We will optimize a newly developed, unique chimeric antigen receptor (CAR) T cell technology to exclusively eliminate autoreactive lymphocytes in an animal model of MS. Further, we will undertake in vivo experiments to develop CAR T cells for pre-clinical translation to humans.

PI_NAMEs: HSIEH, CHYI S;WU, GREGORY  (contact)

PROGRAM_OFFICER_NAME: GUERAU, MIREIA

PROJECT_TERMS: adaptive immunity;Address;Affinity;Algorithms;Animal Model;Antibodies;Antigen Presentation;Antigen Receptors;Antigens;Autoantibodies;Autoantigens;Autoimmune;Autoimmune Diseases;Autoimmunity;Automobile Driving;autoreactive T cell;autoreactivity;B-Lymphocytes;Binding;cancer therapy;CAR T cell therapy;CASP3 gene;CASP8 gene;CD28 gene;CD3 Antigens;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cell Death Induction;cell killing;Cells;Central Nervous System Diseases;chemical reaction;chimeric antigen receptor;chimeric antigen receptor T cells;Chronic;Clinical;CNS autoimmune disease;CNS autoimmunity;CNS Demyelinating Autoimmune Diseases;CRISPR/Cas technology;Data;disability;Disease;Dominant-Negative Mutation;efficacy evaluation;Engineering;Epitopes;Excision;exhaustion;Experimental Autoimmune Encephalomyelitis;experimental study;feasibility testing;Frequencies;Gene Deletion;Gene Targeting;Genes;genetic linkage;Goals;Granzyme;healthcare burden;HLA-DR Antigens;Human;human disease;Immune response;Immune system;Immunosuppression;Immunotherapy;improved;In Vitro;in vivo;in vivo evaluation;Inflammation;JUN gene;Knock-out;Libraries;Lymphocyte;Methodology;Modeling;Modification;mouse model;Multiple Sclerosis;multiple sclerosis treatment;Mus;Myelin Proteins;Nervous System Trauma;neuroinflammation;oligodendrocyte-myelin glycoprotein;optimal treatments;overexpression;Pathogenesis;Pathway interactions;Patients;Peptide Receptor;Peptides;perforin;pre-clinical;Prevention;Proteins;Reaction;receptor;Resolution;response;Severities;Signal Transduction;Specificity;T-Cell Antigen Receptor Specificity;T-Cell Receptor;T-cell receptor repertoire;T-Cell Receptor Therapy;T-Lymphocyte;T-Lymphocyte Epitopes;Technology;Testing;Transgenic Organisms;Translating;translation to humans;Tumor Necrosis Factor-Beta;Validation;vector

PROJECT_TITLE: CAR-T cell treatment of CNS Autoimmunity

STUDY_SECTION: HAI

STUDY_SECTION_NAME: Hypersensitivity, Autoimmune, and Immune-mediated Diseases Study Section[HAI]


ORG_CITY: CAMBRIDGE

ORG_DEPT: CHEMISTRY

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

PHR: Project Narrative: The chemistry we are proposing will allow improved access to molecules of importance in biomedical research in both academia and industry. The ligands, catalysts, techniques, and strategies that we have developed for carbon-heteroatom and carbon-carbon bond formation are regularly used by those in discovery and process groups in the pharmaceutical industry for the preparation of new biologically relevant compounds and are also widely used in academia. The methods we are devising enable chemists to rapidly and reliably prepare molecular analogs that manifest increased potency and reduced side effects as compared to the initial lead compounds, allows for faster, more economical, and efficient drug discovery and development, thus leading to an improvement in human health.

PI_NAMEs: BUCHWALD, STEPHEN L (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TITLE: Metal-Catalyzed Methods for Organic Synthesis


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Neurosciences;Pediatric

ORG_DEPT: PSYCHIATRY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE Anxiety disorders are among the most prevalent childhood psychiatric disorders yet the mechanisms underlying the development of anxiety remain elusive. This proposal examines the neurodevelopmental origins of behavioral inhibition, a risk factor that increases the odds of developing an anxiety disorder by four-fold. By identifying changes in brain connectivity that are linked to behavioral inhibition and the moderating contribution of inhibitory control, this research will generate knowledge that can be used to identify developmentally-sensitive targets for intervention.

PI_NAMEs: FILIPPI, COURTNEY  (contact)

PROGRAM_OFFICER_NAME: THOMAS, LAURA ANDERSON

PROJECT_TERMS: 5 year old;Adolescent;Adult;Age;Anxiety;Anxiety Disorders;Award;Behavior;Behavior assessment;behavior measurement;Behavioral;Behavioral inhibition;Big Data;Brain;career;career development;Child;Childhood;Cognitive;cognitive development;cognitive neuroscience;Complex;connectome;Data;Data Analyses;Data Collection;Data Set;Development;Development Plans;developmental psychology;Distress;early childhood;Emotional;Emotional disorder;executive function;Exhibits;Face;Foundations;Fright;Functional disorder;Functional Magnetic Resonance Imaging;Funding;Goals;high risk;imaging study;improved;improved outcome;independent component analysis;Individual;Individual Differences;infancy;Infant;infant temperament;interest;Intervention;Knowledge;Lead;Life;Link;Magnetic Resonance;Maps;Mental disorders;Mental Health;Mentors;Methods;Modeling;neural;neural correlate;neuroimaging;neuromechanism;Outcome;outcome prediction;Outcomes Research;Pathway interactions;Phase;Prefrontal Cortex;Process;programs;Psychopathology;Recording of previous events;Reporting;Research;Rest;Risk;Risk Factors;Risk Marker;Sample Size;Sampling;skills;social;Specificity;Temperament;Testing;Time;Toddler;Training;vigilance;Visual;Work

PROJECT_TITLE: Identifying neural markers of risk for anxiety in infancy


ADMINISTERING_IC: HL

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Congenital Heart Disease;Congenital Structural Anomalies;Genetics;Heart Disease;Human Genome;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: NARRATIVE This project will investigate the role of cardiac neural crest cells in the mammalian heart development using mouse models and genomic technologies. We will also understand the mechanism by which these cells make cell fate choices as they form the cardiac outflow tract, aortic arch and adjoining arterial branches. The genes that we will investigate are associated with human congenital heart disease, so that we hope, in the future, to translate discoveries in mouse models to human patients.

PI_NAMEs: MORROW, BERNICE E (contact);ZHENG, DEYOU

PROGRAM_OFFICER_NAME: SCHRAMM, CHARLENE A

PROJECT_TERMS: Actins;Affect;Aorta;aortic arch;Arteries;Branchial arch structure;Cardiac;cardiogenesis;Cell Communication;Cell Lineage;Cell Maturation;cell motility;Cell Physiology;cell type;Cells;Cellular biology;Chromosome Mapping;conditional mutant;congenital heart abnormality;Data;Defect;Development;DiGeorge Syndrome;Distal;Embryo;Embryonic Development;Failure;Future;GATA3 gene;gene discovery;Gene Expression;gene function;Gene Mutation;gene regulatory network;Gene Silencing;Genes;Genetic;Genetic Markers;Genomics;Heart;heart defect;heart function;Human;Immunofluorescence Immunologic;In Situ;in vivo;Individual;interest;Knowledge;Mediating;Mesoderm Cell;migration;Molecular;Morphogenesis;Morphology;mouse model;Mus;muscle progenitor cell;mutant;Mutation;Neural Crest;Neural Crest Cell;Neural tube;Pathogenesis;Patients;Persistent Truncus Arteriosus;Pharyngeal Apparatus;Population;Predisposition;Process;progenitor;programs;Risk Factors;Role;Signal Transduction;single cell ATAC-seq;single-cell RNA sequencing;Smooth Muscle;Smooth Muscle Myocytes;Specific qualifier value;stem cells;Structure;Technology;Testing;Tissues;Translating;Vascular Smooth Muscle;whole genome

PROJECT_TITLE: Molecular pathogenesis of congenital heart disease mediated by neural crest and second heart field cells

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CVRS-C(02)]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Data Science

ORG_CITY: LA JOLLA

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: Project Narrative The project will develop and sustain an integrated knowledge base of key research resources, including antibodies, cell lines, organisms and digital assets, indexed by the Research Resource Identifiers (RRID), persistent identifiers currently used by authors to uniquely identify which research resources are used within their studies. Our proven dissemination approaches will encourage biomedical scientists worldwide to use identifiable and validated research resources in their research, leading to measurable improvement and progress toward more rigorous and reproducible biomedical research, one of the major challenges of today’s biomedical science.

PI_NAMEs: BANDROWSKI, ANITA ELZBIETA (contact);GRETHE, JEFFREY S.;HSU, CHUNNAN

PROGRAM_OFFICER_NAME: YU, GUOQIN

PROJECT_TERMS: Antibodies;base;Biomedical Research;biomedical scientist;Cell Line;central database;Collaborations;Communication;Communities;Computer software;Core Facility;Data;Databases;Decision Making;digital;Ensure;Funding;Goals;Growth;Harvest;improved;indexing;Individual;information framework;information gathering;Information Networks;Infrastructure;Journals;Knowledge;knowledge base;knowledge curation;knowledge integration;knowledgebase;Literature;Measurable;model organisms databases;National Institute of Diabetes and Digestive and Kidney Diseases;Neurosciences;Nonprofit Organizations;Organism;outreach;Paper;Plasmids;Process;Reagent;Registries;Reproducibility;Research;Research Personnel;Research Project Summaries;Resources;Role;Science;Scientist;Source;Specific qualifier value;Specificity;Structure;text searching;Time;tool;United States National Institutes of Health;Universities;Validation;web portal;Writing

PROJECT_TITLE: From RRID to Resource Watch: A Knowledgebase of Biomedical Research Resources

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-T(55)R]


NIH_SPENDING_CATS: Clinical Research;Prevention

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE Unplanned ICU admissions from the acute care floor are common and associated with appreciable morbidity and mortality; despite these impacts, little is known about mechanisms underlying these admissions. The proposed research will address this knowledge gap by identifying factors and mechanisms contributing to unplanned ICU admissions and then connecting these factors and mechanisms to key patient- and family- centered outcomes. We will use this fundamental knowledge about unplanned ICU admissions to develop interventions to improve care for seriously ill patients and their family members.

PI_NAMEs: JENNERICH, ANN LONG (contact)

PROGRAM_OFFICER_NAME: ZHOU, GUOFEI

PROJECT_TERMS: Academic Medical Centers;Achievement;acute care;Address;Admission activity;Adverse event;Affect;Age;Anxiety;care costs;Caring;Characteristics;Classification;cohort;Communication;Community Hospitals;Decision Making;depressive symptoms;design;Development;experience;Failure;Family;Family member;Floor;health care settings;Healthcare Systems;high risk;Hospitals;Human;Impairment;improved;improved outcome;Individual;Industry;Information Systems;Intervention;Knowledge;Link;Medical;Modeling;Monitor;Morbidity - disease rate;mortality;mortality risk;Myocardial dysfunction;novel;Outcome;Patient Transfer;Patient-Focused Outcomes;Patients;Positioning Attribute;post-traumatic stress;Prevention;Process;Protocols documentation;psychological distress;psychological symptom;Recovery;Research;respiratory;Respiratory Failure;Safety;safety net;Sample Size;Severity of illness;Standardization;System;therapy development;Work

PROJECT_TITLE: Unplanned ICU Admissions: Understanding Mechanisms and Identifying Associations with Patient- and Family-Centered Outcomes

STUDY_SECTION: HSQE

STUDY_SECTION_NAME: Health Services: Quality and Effectiveness Study Section[HSQE]


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Public Health Relevance Statement Structural racism and discrimination negatively shape the health of older sexual and racial minority men, including those living with HIV. The manner in which structural racism and discrimination affect the various subgroups within this population (along race, ethnicity and HIV status), is expected to vary, yet it is poorly understood. This proposal is in response to NIH’s funding opportunity “Understanding and Addressing the Impact of Structural Racism and Discrimination on Minority Health and Health Disparities” and attends to the Office of AIDS Research Strategic Plan of addressing HIV comorbidities, complications, and health disparities. The purpose of this study is to assess the relationships among health, structural racism and discrimination, stigma, resources, and biomarkers of health and aging in older men of four ethno-racial groups: African American, Latinx, Asian American, and white— and across HIV status. The findings of this study may help understand how structural, individual, and biological factors differently affect the health of older men and the ways in which prevention efforts may be improved.

PI_NAMEs: RAMIREZ-VALLES, JESUS  (contact)

PROGRAM_OFFICER_NAME: GERALD, MELISSA S

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Adherence;Affect;African American;African American population;aged;Aging;aging process;Anti-Retroviral Agents;Area;Asian Americans;Attention;baby boomer;Behavior;Biological;Biological Factors;Biological Markers;Biology;C-reactive protein;Climate;cognitive function;cohort;Communities;community involvement;community partners;comorbidity;Complex;Consequences of HIV;Cross-Sectional Studies;Data;Discrimination;diverse data;Environment;Epidemic;Ethnic Origin;Ethnic Population;ethnoracial;ethnoracial minority;experience;Exposure to;Face;Foundations;Funding Opportunities;Gays;Generations;Goals;Health;health disparity;health inequalities;Heterosexuals;HIV;HIV risk;HIV Seronegativity;HIV/AIDS;Homosexuals;human old age (65+);improved;Individual;Inflammation;Interleukin-10;Interleukin-6;internalized stigma;Intervention;Interview;Latinx;Learning;Length;Lesbian Gay Bisexual Transgender Queer;Leukocytes;Life Cycle Stages;Link;Longitudinal Studies;male;male health;Mediating;men;men of color;Mental Depression;Mental Health;Methods;minority health;minority health disparity;Minority Men;Modeling;multidisciplinary;older men;Older Population;Outcome;peer;Personal Satisfaction;Pharmaceutical Preparations;Population;Prevention;Process;protective factors;public health relevance;Race;racial minority;racial population;racism;Random Allocation;Recording of previous events;Research;research and development;residential segregation;Resources;Respondent;response;Risk;Risk Factors;Role;Sampling;Sampling Biases;San Francisco;sexual minority;Shapes;Social Environment;social integration;social stigma;Social support;Strategic Planning;Stress;Structural Racism;Structure;Subgroup;substance use;telomere;Testing;theories;TNF gene;United States National Institutes of Health

PROJECT_TITLE: Structural Racism and Discrimination in Older Men's Health Inequities


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Gene Therapy;Genetics;Immunotherapy;Infectious Diseases

ORG_CITY: ATLANTA

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: GEORGIA INSTITUTE OF TECHNOLOGY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Antigen-specific CD8 T cells are key players in adaptive immunity and have transformative applications as cell therapies. Yet isolating these cells is challenging because of their receptor diversity and rarity. We propose to develop DNA-gated cytometry for multiplexed sorting of Ag-specific CD8 T cells to overcome current challenges.

PI_NAMEs: KWONG, GABRIEL A (contact)

PROGRAM_OFFICER_NAME: MALLIA, CONRAD M

PROJECT_TERMS: adaptive immunity;Affinity;Antibodies;Antigens;Avidity;Benchmarking;Binding;Biological Assay;cancer cell;CAR T cell therapy;CD19 gene;CD8-Positive T-Lymphocytes;Cell Death;Cell Fraction;Cell Physiology;Cell Separation;Cell Therapy;Cells;chimeric antigen receptor T cells;Couples;Cytomegalovirus;Cytometry;cytotoxicity;design;Dissociation;DNA;DNA Integration;DNA Sequence;Engineering;Fluorescence;Fluorescence-Activated Cell Sorting;fluorophore;Generations;HLA-A2.1;Human;Human Herpesvirus 4;in vivo;Individual;Infection;Influenza;K562 Cells;Label;Length;Libraries;Light;Lymphocytic choriomeningitis virus;magnetic beads;Magnetism;Major Histocompatibility Complex;manufacture;Mediating;mitochondrial dysfunction;Modeling;Molecular;monomer;mouse model;Mus;neoplastic cell;novel strategies;Oligonucleotides;Peptide/MHC Complex;Peptides;Phenotype;Population;prevent;Process;Production;Raji Cell;Reaction;receptor;Receptor Activation;Receptor Cell;Sampling;shear stress;Sorting;Splenocyte;success;T cell therapy;T-Cell Receptor;T-cell receptor repertoire;T-Lymphocyte;T-Lymphocyte Epitopes;Technology;Testing;transduction efficiency;Transgenic Mice;translational potential;Ultraviolet Rays;Viral;Virus;Virus Diseases;Work

PROJECT_TITLE: DNA-gated cytometry for multiplexed sorting of antigen-specific CD8 T cells

STUDY_SECTION: CMT

STUDY_SECTION_NAME: Cellular and Molecular Technologies Study Section[CMT]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Biotechnology;Cancer;Emerging Infectious Diseases;Genetics;Hematology;Infectious Diseases;Lung;Lymphatic Research;Lymphoma;Rare Diseases

PHR: Project Narrative The proposed research will offer insights into the key fundamental processes that enable cells to repair and tolerate damage to their genetic material in response to environmental mutagens. These processes are responsible for the mutations that lead to cancer and a variety of human genetic diseases. The proposed research should also lead to the development of new classes of drugs to inhibit these processes that could have significant therapeutic applications.

PI_NAMEs: WALKER, GRAHAM C (contact)

PROGRAM_OFFICER_NAME: SHAUGHNESSY, DANIEL

PROJECT_TERMS: Adjuvant Chemotherapy;Affect;Aging;Amino Acids;anthrax protective factor;Basic Science;Binding;Biological;Biology;C-terminal;Cell fusion;Cells;chemotherapy;Complex;crosslink;Development;DNA;DNA biosynthesis;DNA crosslink;DNA Damage;DNA lesion;DNA Repair;DNA-Directed DNA Polymerase;Dominant-Negative Mutation;environmental chemical;Environmental Exposure;environmental mutagens;Escherichia coli;Family;Funding;Genetic;Genetic Diseases;Genetic Materials;Goals;Grant;Health;Human;human disease;Human Genetics;human model;improved;inhibitor;innovation;insight;lethal factor;loss of function;Lung Lymphoma;Malignant neoplasm of lung;Malignant Neoplasms;Mammalian Cell;member;Molecular;mouse model;Mutagenesis;mutant;Mutation;National Institute of Environmental Health Sciences;novel;novel drug class;operation;Organism;Pathway interactions;Peptides;Physiological;Process;protein complex;Proteins;Regulation;repaired;Research;Resistance;Resolution;response;Role;Saccharomyces cerevisiae;Series;small molecule;System;Testing;Therapeutic;virtual

PROJECT_TITLE: Mechanism of Eukaryotic Environmental Mutagenesis


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

ORG_CITY: GABORONE

ORG_COUNTRY: BOTSWANA

ORG_FIPS: BC

ORG_NAME: BOTSWANA-HARVARD AIDS INSTITUTE

PHR: Narrative The project aims to develop specialized HIV-1 genomics laboratory training modules at BHP to build capacity for laboratory professionals and university students on HIV-1 genomics, and HIV-1 cure-related research in Botswana and the region. The proposed project will increase the human capacity for conducting advanced HIV-1 genomics research and establishing local capacity for HIV-1 Reservoirs studies to contribute toward HIV cure-related research in southern Africa. Successful implementation of this project will also result in the establishment of a core facility and center of excellence for pathogen genomics, and support future NIH- funded HIV-1 cure projects. 1

PI_NAMEs: GASEITSIWE, SIMANI  (contact)

PROGRAM_OFFICER_NAME: BANSAL, GEETHA PARTHASARATHY

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Adolescent;Affect;Africa South of the Sahara;African;Anti-Retroviral Agents;antiretroviral therapy;Area;Bioinformatics;Biological Assay;Boston;Botswana;Certification;Clinical;Clinical Research;Clinical Trials;cohort;Collaborations;community advisory board;Core Facility;Country;Data;Data Analyses;Development;Diagnosis;DNA;Drug resistance;Educational workshop;emerging pathogen;epidemiology study;Evolution;experience;Faculty;Flow Cytometry;Funding;Future;Generations;Genomic Segment;Genomics;Genotype;graduate student;Grant;Health Personnel;HIV;HIV-1;HIV-1 vaccine;Human;implementation science;improved;Incidence;Infant;Institution;interest;Investigator-Initiated Research;Investments;Knowledge;Laboratories;laboratory experience;Laboratory Scientists;member;Molecular;Molecular Virology;mortality;Mother-to-child HIV transmission;next generation sequencing;Observational Study;Output;pathogen;pathogen genomics;Patients;Persons;Pharmaceutical Preparations;pressure;Prevalence;Prevention strategy;professional students;programs;Public Health;Public Health Schools;Research;Research Personnel;resistance mutation;Rest;SARS-CoV-2 B.1.1.529;Scientist;skills;Southern Africa;Students;success;Training;Training Activity;treatment program;United States National Institutes of Health;Universities;university student;Vaccine Design;variants of concern;Viral;virtual;Work;World Health Organization

PROJECT_TITLE: Developing Botswana Laboratory Capacity in HIV Genomics and HIV Cure

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DCAI-D(56)]


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Genetics;Neurodegenerative;Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIV NEW YORK MORNINGSIDE

PHR: Project Narrative: The experiments described in this proposal are designed to increase our understanding of the mechanisms and regulation of essential mRNA processing reactions, and how they are coupled to and affect other nuclear processes such as transcription. Recent studies have revealed that changes in these processes occur and have important consequences during development and disease, especially neurodegenerative diseases and cancer, and our studies will provide considerable mechanistic insight into these important processes.

PI_NAMEs: MANLEY, JAMES L. (contact)

PROGRAM_OFFICER_NAME: CZAPLINSKI, KEVIN

PROJECT_TERMS: Affect;Amyotrophic Lateral Sclerosis;Anemia;Anti-viral Response;Area;Brain;cell type;cofactor;Complex;Coupled;Cytoplasm;design;Development;Disease;Event;exosome;experimental study;frontotemporal lobar dementia amyotrophic lateral sclerosis;GATA1 gene;Genes;Genetic Transcription;Goals;Homeostasis;Human;human embryonic stem cell;insight;Lead;Malignant Neoplasms;MAP3K7 gene;Membrane Proteins;Messenger RNA;Motor Cortex;mRNA Precursor;Mutation;Neoplasms;Neurodegenerative Disorders;NF-kappa B;Nuclear;Nuclear Inner Membrane;Nuclear Pore Complex;Nuclear Pore Complex Proteins;Open Reading Frames;p38 Mitogen Activated Protein Kinase;Pathway interactions;Patients;permissiveness;Physiological;Polyadenylation;Pre-mRNA Polyadenylation Factor;Process;Protein Isoforms;Proteins;Reaction;Regulation;RNA;RNA Helicase;RNA Splicing;Sampling;SARS-CoV-2 infection;Specificity;sporadic amyotrophic lateral sclerosis;Suggestion;Translating;Work

PROJECT_TITLE: Regulation of mRNA processing: Mechanisms and Consequences

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-K(55)R]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: BOSTON

ORG_DEPT: GENETICS

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: PROJECT NARRATIVE Understanding the molecular mechanisms underlying muscle growth and wasting is highly relevant to conditions such as anorexia and sarcopenia, and diseases such as cachexia. We will study these mechanisms in Drosophila, a well-established model for the study of muscle biology.

PI_NAMEs: PERRIMON, NORBERT  (contact)

PROGRAM_OFFICER_NAME: LINDHURST, MARJORIE JEAN

PROJECT_TERMS: Activities of Daily Living;Adult;Affect;age-related disease;aged;Aging;Anorexia;Atrophic;Automobile Driving;Autophagocytosis;Biogenesis;Biology;Cachexia;Cancer Cachexia;Cells;Cessation of life;Defect;Degradation Pathway;Diabetes Mellitus;Disease;Drosophila genus;Elderly;Equilibrium;Event;Exercise;Fibroblast Growth Factor;fly;frailty;FRAP1 gene;Genes;Genetic Transcription;Growth;Heart Diseases;Homeostasis;Human body;IGF1 gene;Injury;insight;Insulin;Label;Lysosomes;Maintenance;Malignant Neoplasms;Metabolism;Methods;Midgut;mitochondrial dysfunction;Modeling;Molecular;Morphology;multicatalytic endopeptidase complex;Muscle;Muscle Contraction;muscle form;muscle strength;Muscular Atrophy;novel;nutrition;obesity risk;Organelles;Organism;Pathway interactions;Phenotype;Play;Process;protein aggregation;Protein Biosynthesis;protein degradation;Proteins;Proteomics;Proto-Oncogene Proteins c-akt;Regulation;response;Risk;RNA;Role;sarcopenia;Signal Pathway;Signal Transduction;Sirolimus;Skeletal Muscle;skeletal muscle wasting;Study models;System;Systemic disease;Tissues;transcription factor;tumor;Tumor-Derived;Ubiquitin;wasting

PROJECT_TITLE: Characterization of the Insulin to Autophagy Pathway in Muscles

STUDY_SECTION: SMEP

STUDY_SECTION_NAME: Skeletal Muscle and Exercise Physiology Study Section[SMEP]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_NAME: NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC

PHR: The HIV Center will advance the goals of the US National HIV/AIDS Strategy, the NIH, and UNAIDS to End the HIV/AIDS Epidemic (EHE), by stimulating and supporting research that targets the US and global communities most affected by racial, social, and health disparities; mental health challenges; and health inequities. We will build and expand on our history of interdisciplinary HIV research – leveraging emerging knowledge bases and new and continuing community, scientific, and health department partnerships --to promote research focusing on individual, social, and systemic barriers to actualizing the power of biomedical advances in HIV prevention and care for the most vulnerable. We will identify and rapidly respond to new trends in viral epidemics supporting research-practice partnerships that foster innovation, train the next generation of scientific leaders, including those from under-represented groups, increase understanding of drivers of the epidemic, and foster translation of clinical and research findings to prevention and care settings for maximum equitable public health impact.

PI_NAMEs: REMIEN, ROBERT H (contact)

PROGRAM_OFFICER_NAME: GORDON, CHRISTOPHER M

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Adherence;Advocacy;Affect;AIDS prevention;analytical method;base;Behavioral;behavioral and social science;Behavioral Research;behavioral study;Biomedical Research;care providers;Caring;Cessation of life;Clinical;clinical care;clinical center;Clinical Research;clinical translation;Communities;community based service;community partners;Complement;Country;COVID-19 pandemic;Data;Data Analytics;data management;Data Science;Data Science Core;design;Development;Diamond;Endowment;Ensure;Epidemic;Equity;Ethics;ethnic disparity;Faculty;Fostering;Foundations;Goals;Health;health determinants;health disparity;health equity;health inequalities;Healthcare;Healthcare Systems;Heart;HIV;HIV disparities;HIV/AIDS;implementation science;Individual;Inequity;innovation;Institution;Intervention;Knowledge;Leadership;low and middle-income countries;marginalization;Mediating;Medical center;Mental Health;Methodology;Monkeypox;New York;New York City;next generation;outcome disparities;Partnership Practice;Personnel Management;Persons;Pilot Projects;Policies;Politics;Population;Prevention;programs;Psychiatry;Public Health;public health emergency;Public Health Schools;racial disparity;Recording of previous events;Reduce health disparities;Research;Research Design;Research Personnel;Research Support;response;Role;scale up;Scientist;social;social disparities;social health determinants;statistics;Strategic Planning;substance misuse;systemic barrier;Targeted Research;Testing;therapy development;Training;Translational Research;transmission process;trend;Underrepresented Populations;United States National Institutes of Health;Universities;uptake;Vaccines;Viral;viral epidemic;Vulnerable Populations

PROJECT_TITLE: HIV Center for Clinical and Behavioral Studies


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Patient Safety;Prevention

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Administrative Efficiency;Administrator;AIDS prevention;Behavioral;behavioral study;Caring;catalyst;Clinic;Clinical;clinical center;Clinical Psychology;Clinical Research;Clinical Trials Data Monitoring Committees;Collaborations;Communication;Communities;community organizations;community partnership;Country;Data Security;design;Development;Discipline;Doctor of Philosophy;Electronics;Ensure;Environment;Epidemic;experience;forging;Foundations;Gender;Goals;Grant;Health;health disparity;Health Promotion;HIV;HIV/AIDS;implementation science;Individual;Information Technology;innovation;Institution;International;Leadership;Master of Business Administration;Master of Public Health;Medical;Medical center;Medical Psychology;meetings;member;Mental Health;Modeling;Monitor;multidisciplinary;New York;Newsletter;Online Systems;operation;Performance;Policies;Positioning Attribute;Process;Productivity;professor;Psychiatry;Public Health;Public Health Schools;Research;Research Personnel;Research Project Grants;Resources;Science;Scientist;Seminal;Sexuality;social;Source;Strategic Planning;symposium;synergism;Training;Training Programs;Underrepresented Populations;Universities;Update;web site;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: COLUMBIA

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

ORG_STATE: SC

PHR: Project Narrative This study is relevant to public health because it represents a novel strategy for identifying, based on prior risk exposure patterns, those who benefit from family interventions and those who may need additional or alternative intervention. Once these families are identified, interventions can be tailored to produce maximum benefit for families experiencing various combinations of risk factors. The project aligns with Goal 3 of NIMH’s Strategic Plan to advance the prevention of mental illness by improving methods to match interventions to individuals and populations.

PI_NAMEs: COOPER, DANIEL KABAT (contact)

PROGRAM_OFFICER_NAME: ROONEY, MARY

PROJECT_TERMS: Address;Adolescent;Alternative Therapies;behavioral outcome;Child;Child Rearing;Conflict (Psychology);coping;cost effectiveness;Couples;Data;Depressed mood;Disadvantaged;Distal;economic disparity;economic need;Economics;Education;Educational Intervention;Effectiveness;Effectiveness of Interventions;Elements;Employment;Ensure;Evidence based intervention;Evidence based program;experience;Exposure to;Family;Family Process;Family Relationship;fatherhood;Fathers;follow up assessment;Functional disorder;gender difference;Goals;Health;Health Promotion;improved;Income;Individual;interest;Intervention;intervention effect;Literature;Low income;lower income families;Marital Relationships;Marriage;Mental Depression;Mental disorders;Mental Health;Methods;Modeling;Mothers;National Institute of Mental Health;novel strategies;Occupations;Outcome;Parents;Participant;patient engagement;Pattern;person centered;Personal Satisfaction;Persons;physical conditioning;Population;Poverty;prevent;Prevention;Prevention program;preventive intervention;Process;Program Effectiveness;programs;promote resilience;Public Health;racial difference;racial disparity;Randomized;Recommendation;Reporting;Research;resilience;responders and non-responders;response;Risk;Risk Factors;skills;sociodemographics;Strategic Planning;Stress;stress management;stressor;substance use;Testing;therapy design;Time;Victimization

PROJECT_TITLE: Maximizing the Impact of Preventive Interventions: Identifying Responders and Non-Responders of an Evidence-Based Intervention for Low-Income Families Using a Person-Centered Approach

STUDY_SECTION: HPC

STUDY_SECTION_NAME: Health Promotion in Communities Study Section[HPC]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Prevention

PI_NAMEs: SANDFORT, THEODORUS G.M. (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;AIDS prevention;Applications Grants;Awareness;behavioral and social science;behavioral study;Bioethics;Biomedical Research;career;Climate;Clinical;clinical center;Clinical Research;Collaborations;Communities;Complement;Consultations;Critical Thinking;Development;Discipline;Doctor of Medicine;Doctor of Philosophy;doctoral student;Educational workshop;Ensure;Epidemic;Equity;equity, diversity, and inclusion;Ethics;Extramural Activities;Faculty;flexibility;frontier;Funding;Funding Opportunities;Generations;Grant;health disparity;health equity;health goals;Health Policy;health practice;HIV;Individual;innovation;Interdisciplinary Study;International;Leadership;Learning;Manuscripts;Master of Public Health;meetings;member;Mental Health;Mentors;Monitor;multidisciplinary;National Institute of Mental Health;New York;Outcome;Phase;Pilot Projects;Policies;Policy Maker;Positioning Attribute;post-doctoral training;Postdoctoral Fellow;Prevention Research;programs;Psychiatry;Psychologist;Public Health;Publications;Records;Research;research and development;Research Ethics;Research Personnel;Research Priority;Resources;response;Science;Scientific Advances and Accomplishments;Sexuality;social;social science research;Training Programs;Translations;treatment research;United States National Institutes of Health;Universities;Work;working group;Writing

PROJECT_TITLE: Development Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Frontotemporal Dementia (FTD);Genetic Testing;Genetics;Human Genome;Neurodegenerative;Neurosciences;Orphan Drug;Prevention;Rare Diseases

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative Neurodegenerative diseases including Alzheimer’s disease and Progressive Supranuclear Palsy are characterized by abnormal tau protein accumulation and do not currently have disease modifying treatments. Analyzing whole genome sequencing with novel genomic and genome informatic methods may identify rare genetic risk factors that lead to these diseases. The shared or unique rare genetic risk factors of Alzheimer’s disease and Progressive Supranuclear Palsy may become future therapeutic targets.

PI_NAMEs: CHANG, TIMOTHY S (contact)

PROGRAM_OFFICER_NAME: MARTIN, DAMALI

PROJECT_TERMS: 3-Dimensional;Aging;Algorithms;Alzheimer's Disease;Alzheimer's disease risk;Biological;Biological Assay;biomedical informatics;career;career development;Chromatin Structure;Clinical;clinical care;Clinical Informatics;Code;cohort;Collaborations;computing resources;Data;Data Set;dementia risk;Development Plans;Disease;disorder risk;Economics;endophenotype;Environment;Faculty;forging;Frequencies;functional genomics;Future;gene network;Genes;Genetic;Genetic Risk;genetic risk factor;genetic variant;Genome;genome sequencing;genomic data;Genomic Segment;Genomics;Goals;Grouping;healthcare burden;Heritability;improved;Individual;Informatics;Knowledge;Laboratories;Measures;meetings;Mentorship;Methods;Monitor;Nerve Degeneration;neurodegenerative dementia;Neurodegenerative Disorders;new therapeutic target;novel;Nucleic Acid Regulatory Sequences;Pathologic;Pathway interactions;precision medicine;Progressive Supranuclear Palsy;Proteins;Quantitative Trait Loci;Rare Diseases;rare variant;Reporter;Research;Resources;risk variant;Scientist;Syndrome;tau aggregation;tau mutation;tau Proteins;Tauopathies;Testing;therapeutic development;therapeutic target;Training;Untranslated RNA;Validation;Variant;whole genome;Work

PROJECT_TITLE: Rare Genetic Risk and Gene Networks in Tauopathy

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Basic Neuroscience of Aging Study Section[NIA-N]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences

ORG_NAME: SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

PHR: Project Narrative This proposal will transform the study of brain science and its diseases, particularly Alzheimer’s disease and its related dementias, through the study of a new, fundamental phenomenon: somatic gene recombination (SGR). SGR generates myriad, previously unassessed genomic cDNAs (gencDNAs) that have functional implications for biology and diseases of the brain. The proposed studies have the potential to link AD and ADRDs mechanistically, as well as identify novel biomarkers and near-term therapeutics, based on the identified enzymology required for SGR.

PI_NAMEs: CHUN, JEROLD  (contact)

PROGRAM_OFFICER_NAME: YAO, ALISON Q

PROJECT_TERMS: Abbreviations;Affect;aged;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease related dementia;Alzheimer's disease therapeutic;Alzheimer's disease therapy;Amyloid beta-Protein Precursor;Amyotrophic Lateral Sclerosis;antiretroviral therapy;Area;Biochemical;Bioinformatics;Biological;Biological Markers;Biological Sciences;Biology;Brain;brain cell;Brain Diseases;cancer therapy;Cell Culture Techniques;Cells;chimeric antigen receptor T cells;Clinical Trials;Cognition;cognitive function;Complementary DNA;Consensus;Copy Number Polymorphism;Dementia;Disease;Disease Progression;DNA;DNA Sequence Alteration;empowerment;Endogenous Retroviruses;Enzymatic Biochemistry;Enzymes;Epidemiology;Exposure to;Failure;FDA approved;Fluorescent in Situ Hybridization;Frontotemporal Lobar Degenerations;Genes;Genetic Recombination;genetic variant;Genome;genome sciences;Genomics;Gifts;Health;HIV;Human;Huntington Disease;Immune system;improved;Incidence;Individual;Information Retrieval;Information Storage;innovation;insight;Introns;Learning;Lewy Body Dementia;Link;Liquid substance;Medicine;Memory;Molecular;mosaic nature;neural;Neuroanatomy;Neurobiology;Neurons;Neurosciences;new therapeutic target;next generation sequencing;novel marker;novel strategies;Nucleotides;Parkinson's Dementia;Pathogenesis;Pathogenicity;Pathologic;Patients;Peptide Nucleic Acids;Ploidies;postmitotic;Prevalence;programmed cell death protein 1;RAG1 gene;repaired;Research;Research Personnel;Retrieval;Reverse Transcriptase Inhibitors;RNA;RNA Sequences;RNA-Directed DNA Polymerase;Sampling;Science;Signal Transduction;single molecule;societal costs;Testing;theories;Therapeutic;Therapeutic Uses;Time;V(D)J Recombination;Variant;Work

PROJECT_TITLE: Transformative research on somatic gene recombination in the normal and Alzheimer's disease-related dementia brain

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BCMB-A(51)]


ORG_CITY: PITTSBURGH

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: NARRATIVE Aging of the reproductive tissues increases susceptibility to numerous age-related comorbidities and mortality and thus has relevance well beyond implications for procreation. While numerous advances have been made in studying organismal aging, the area of reproductive aging has not received adequate attention for education, research and discovery, especially at an institutional level. This application proposes to create an educational, research and mentoring program focused on reproductive aging to establish it as an institutional goal at the University of Pittsburgh and beyond.

PI_NAMEs: GHAZI, ARJUMAND  (contact)

PROGRAM_OFFICER_NAME: CARTER, CHRISTY

PROJECT_TERMS: Address;Age related comorbidities;age related deterioration;Aging;aging population;aging related;Animals;anti aging;Area;Attention;Award;Bachelor's Degree;Basic Science;Biology;Brothers;Cardiovascular Diseases;career;Career Choice;Career Mobility;Clinic;Clinical;Committee Members;Communities;comorbidity;Country;Coupled;Dedications;Delayed Childbearing;Development;Diverse Workforce;Economics;Education;Educational Curriculum;Educational workshop;Elderly;Enrollment;Epidemiology;Exhibits;experience;extend lifespan;Faculty;Fellowship;Female;female fertility;Fertility;Foundations;Funding;Future;Geriatrics;Geroscience;gerotherapeutic;Goals;Graduate Degree;graduate student;Health;Health Sciences;healthspan;healthy aging;Human;Impaired cognition;Impairment;Infrastructure;Institution;interest;Intervention;Knowledge;Lead;Leadership;Life;Life Expectancy;life span;Link;Longevity;Medical Students;men;Menopause;Mentors;Mentorship;Molecular;mortality;Neurologic;Newsletter;Osteoporosis;Outcome;Participant;Pathway interactions;Positioning Attribute;Postdoctoral Fellow;Predisposition;Pregnancy;preservation;programs;Public Health;recruit;Reproduction;reproductive;reproductive fitness;Reproductive Health;reproductive senescence;Reproductive system;Research;Research Institute;Research Personnel;sabbatical;Science;sex;Students;summer research;System;Talents;Testosterone;Tissues;Training;Travel;trend;undergraduate student;Universities;web site;Woman;Women's Health

PROJECT_TITLE: A Pipeline for Research, Education and Mentoring in Reproductive Aging

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development for Established Investigators and Conference Grants Study Section[AGCD-4]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Brain Disorders;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Racial and Ethnic Minority Health Research;Social Determinants of Health;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PHR: Project Narrative The proposal entitled “Impact of prenatal inflammation on developing human brain” will study the consequences of (co-) exposure to maternal inflammation due to bacterial or viral infections toxins on developing human neuroimmune system using human iPSC-derived cerebral organoids co-cultured with microglial cells. Studies using iPSCs have been limited in sample size and lacked diversity, often derived from a single race/ethnical group. Here, we will collect samples from a diverse ethnical and racial group of healthy individuals, representative of the proportions found in the U.S. population, that will help us better understand the health disparities and interventions both in populations and in specific subgroups, identifying new therapeutic targets leading to more efficient therapies from which the majority of the population in the US could benefit from.

PI_NAMEs: MUOTRI, ALYSSON R. (contact)

PROGRAM_OFFICER_NAME: MAJJI, SAI PRASANNA

PROJECT_TERMS: Acceleration;Acute;American;Apoptosis;Appearance;autism spectrum disorder;Bacterial Infections;Biological Assay;Birth;Brain;brain cell;brain parenchyma;cell type;Cells;Central Nervous System;Cerebrum;Chronic;Coculture Techniques;cohort;Data;Detection;Development;developmental disease;Dimensions;Disease;disorder risk;Electroencephalography;Embryonic Development;Environment;Environmental Impact;Environmental Risk Factor;Epigenetic Process;ethnic diversity;Ethnic Origin;Ethnic Population;experience;experimental study;Exposure to;fetal;Fetal Development;first responder;Gender;Genes;Genetic Transcription;gliogenesis;Goals;health disparity;healthy pregnancy;Hormones;Human;human induced pluripotent stem cells;Immune;immune activation;Immune system;in utero;in vitro Model;Individual;induced pluripotent stem cell;Infection;Infectious Agent;Inflammation;Inflammatory;Intervention;Invaded;Knowledge;Life;life span;Link;Lipopolysaccharides;Macrophage;Measures;Microglia;Modeling;Molecular;multi-electrode arrays;Nervous System Disorder;neural network;neurodevelopment;Neurodevelopmental Disorder;Neuroimmune;Neuroimmune system;neuron development;Neurons;new therapeutic target;Organoids;Penetration;Persons;Phenotype;Physiological;Poly I-C;Population;population based;Pregnancy;Premature Birth;Premature Infant;prenatal;prenatal disorder;Proteins;Race;racial population;Risk;Role;Sample Size;Sampling;Shapes;single cell ATAC-seq;single-cell RNA sequencing;Streptococcus Group B;Subgroup;Synapses;synaptogenesis;System;Systems Development;targeted treatment;Testing;three-dimensional modeling;Thyroid Hormones;Time;tool;Toxin;transcriptomics;United States;Viral;Virus Diseases;Yolk Sac;Zika Virus


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Data Science;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Prevention

PI_NAMEs: PAVLICOVA, MARTINA  (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Adherence;analytical method;Applications Grants;Archives;Area;behavioral and social science;behavioral study;Biomedical Technology;Biometry;career;Caring;clinical center;Clinical Research;Collaborations;Communication;Communication Methods;Communities;Consultations;Data;Data Analytics;Data Collection;data harmonization;data management;data quality;data repository;Data Science;Data Science Core;Data Security;Data Set;data sharing;data sharing networks;Database Management Systems;Databases;Development;digital;Doctor of Philosophy;Education;Effectiveness;Elements;Ensure;Epidemic;Evidence based intervention;Future;Generations;Goals;health disparity;HIV;improved;innovation;insight;Knowledge;Leadership;learning strategy;Machine Learning;machine learning method;Manuscripts;member;Mental Health;Meta-Analysis;Metadata;Methods;mid-career faculty;Modernization;multimodality;National Institute of Mental Health;novel;Phase;podcast;Policies;Preparation;Prevention;Productivity;Psychiatry;Public Health;Public Health Schools;public repository;Research;Research Design;Research Personnel;Resource Sharing;Resources;Risk;Secure;Series;skills;social disparities;social science research;sound;Source;Statistical Data Interpretation;Statistical Methods;statistics;Techniques;tool;Translational Research;transmission process;Universities;Work;Writing

PROJECT_TITLE: The Statistics, Data Science, and Data Management (SDM) Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biodefense and Related Countermeasures;Biotechnology;Brain Disorders;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Dementia;Emerging Infectious Diseases;Genetics;Human Genome;Infectious Diseases;Neurodegenerative;Neurosciences;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID;Prevention;Social Determinants of Health

ORG_CITY: CLEVELAND

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: NARRATIVE Alzheimer disease (AD) and related disorders (ADRD) are the most common causes of cognitive impairment in older individuals, with no effective long-term treatment or prevention. Examining genetic and biomarker profiles of older, cognitively unimpaired individuals will provide insight into AD/ADRD protective biological mechanisms. This will be done leveraging and building on our unique family-based longitudinal cohort of mid- Western Amish individuals.

PI_NAMEs: HAINES, JONATHAN L (contact);PERICAK-VANCE, MARGARET A.;SCOTT, WILLIAM K

PROGRAM_OFFICER_NAME: FENG, LI REBEKAH

PROJECT_TERMS: Acceleration;Affect;Alleles;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Amish;Amyloid beta-Protein;biobank;Biological;Biological Markers;Blood specimen;case control;Case/Control Studies;Chromosome 17;Clinical Trials;Cognition;Cognitive;cognitive performance;cohort;Collaborations;Collection;Communities;COVID-19;Data;data integration;data repository;Data Set;design;Development;DNA;druggable target;Education;effective therapy;Enrollment;Environmental Risk Factor;experience;Family;follow-up;Foundations;Founder Generation;Future;Gene Expression;Genes;Genetic;genetic association;genetic linkage analysis;genetic variant;Genetic Variation;genome wide association study;Genomics;Genotype;Goals;health data;high risk;Impaired cognition;in silico;In Vitro;Indiana;Individual;induced pluripotent stem cell;insertion/deletion mutation;insight;Light;Long COVID;Longitudinal cohort;Longitudinal Studies;Maps;Measures;Natural Immunity;Neurodegenerative Disorders;neurofilament;Neuropsychology;novel;Occupations;Ohio;Older Population;Participant;Pathway interactions;Peripheral Blood Mononuclear Cell;Phenotype;Plasma;Population;pre-clinical;preservation;Prevention;Process;progression marker;protective allele;protective factors;protein expression;rare variant;Recording of previous events;Research;Research Design;risk prediction model;risk variant;RNA;Running;Sampling;SARS-CoV-2 exposure;SARS-CoV-2 infection;Signal Transduction;SNP array;social health determinants;Subgroup;tau Proteins;tau-1;Testing;Variant

PROJECT_TITLE: Protective Genetic Variants for Alzheimer Disease in the Amish - RENEWAL

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-L(90)]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Genetics;Human Genome;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Precision Medicine;Radiation Oncology;Rare Diseases

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

PHR: PROJECT NARRATIVE Diffuse midline gliomas with the H3K27M mutation, which includes the previously named Diffuse Intrinsic Pontine Glioma (DIPG), are the most aggressive primary malignant brain tumors in children with the median survival of this group about one year after diagnosis with no effective therapies available. Recent studies have identified somatic mutation of the H3F3A gene that encodes the histone H3 variant, H3.3, which results in lysine 27 to methionine change (K27M) in the encoded protein H3.3 in most DIPG tumors. The planned studies will not only make basic scientific discoveries aimed at understanding the molecular basis of tumorigenesis, but also lay the foundation for molecularly targeted therapies for this deadly disease.

PI_NAMEs: DANIELS, DAVID  (contact)

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: Affect;Animal Experimentation;Animal Model;Animals;aurora kinase;aurora kinase A;Automobile Driving;Brain;Brain Neoplasms;Brain Stem;cancer cell;Cell Cycle;Cell Line;Cell Physiology;Cell Survival;Cells;Cessation of life;Child;Childhood;Childhood Glioma;ChIP-seq;Chromatin Structure;Chromosomal Instability;Clinic;Clinical;Clinical Trials;Data;Diagnosis;Diffuse intrinsic pontine glioma;diffuse midline glioma;Disease;Drug Delivery Systems;Drug Screening;Drug Targeting;effective therapy;efficacy evaluation;epigenetic marker;Epigenetic Process;epigenetic regulation;epigenome;epigenomics;experimental study;Foundations;Gene Expression;Gene Expression Profile;gene repression;Genes;Glioma;Goals;H3 K27M mutation;Histone H3;histone methylation;Histones;In Vitro;inhibitor;kinase inhibitor;life span;live cell imaging;Lysine;Malignant neoplasm of brain;Malignant Neoplasms;Medicine;Methionine;Methylation;methylation pattern;Mitosis;Mitotic;Molecular;molecular targeted therapies;Mus;Mutation;Names;neoplastic cell;Neurosurgeon;non-invasive monitor;novel therapeutics;Nucleosomes;palliative;Pathologic;patient derived xenograft model;Patients;Pattern;Pediatric Neoplasm;pediatric patients;Pharmaceutical Preparations;pharmacologic;Pharmacotherapy;Phosphorylation;Plasma;potential biomarker;preclinical study;programs;Proliferating;protein H(3);Radiation Oncologist;Radiation therapy;Radiation Tolerance;Radiation-Sensitizing Agents;Radiosensitization;Research;Role;Site;Somatic Mutation;success;targeted treatment;Testing;Therapeutic;treatment effect;treatment response;tumor;Tumor Cell Line;Tumor-Derived;tumorigenesis;Universities;Variant;Vision;Xenograft Model

PROJECT_TITLE: Working towards targeted therapy in H3K27M tumors: Aurora Kinase Inhibitors and the role of epigenome programming

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


ORG_CITY: MINNEAPOLIS

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF MINNESOTA

PHR: Public health relevance This proposal incorporates leading-edge genetic and physiological studies to investigate contractile proteins that control skeletal muscle performance in health and in disease. Therefore, the health relevance of the proposal is substantial and highly significant to the mission of the National Institutes of Health.

PI_NAMEs: METZGER, JOSEPH MARK (contact)

PROJECT_TERMS: Address;Arthrogryposis;biophysical analysis;Biosensor;Breathing;Characteristics;Chemosensitization;Contractile Proteins;Contracture;Data;Disease;Distal;effective therapy;Fluorescence Resonance Energy Transfer;Functional disorder;Genetic;Health;Human;Hyperactivity;Inherited;innovation;life span;mechanical load;mechanotransduction;Memory;Microfilaments;Mission;Modeling;Molecular Conformation;Movement;Muscle;Muscle function;Muscle Weakness;Muscular Dystrophies;Myopathy;Myosin ATPase;myosin-binding protein C;Nemaline Myopathies;novel;novel therapeutics;Performance;Personal Satisfaction;Pharmaceutical Preparations;Phosphorylation;Physiological;prevent;Process;public health relevance;Regulation;Reporting;restoration;Role;Sarcomeres;Signal Transduction;skeletal;Skeletal Muscle;small molecule;stem;Stimulus;Striated Muscles;Structure;System;targeted treatment;Testing;Therapeutic Intervention;Thin Filament;Time;tool;Tropomyosin;Troponin;United States National Institutes of Health;Walking

PROJECT_TITLE: Skeletal muscle sarcomere function in health and disease


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Immunization;Infectious Diseases;Mental Health;Prevention;Social Determinants of Health;Vaccine Related

PI_NAMEs: TROSS, SUSAN  (contact)

PROJECT_TERMS: Address;Adherence;Adoption;Affect;AIDS prevention;Anti-Retroviral Agents;Attitude;behavior change;behavior measurement;Behavior Therapy;Behavioral;Behavioral Sciences;behavioral study;Bioinformatics;Caring;Client;Clinic;Clinical;clinical center;Clinical Research;Clinical Sciences;Clinical Services;clinical translation;Communication;Communities;Continuity of Patient Care;COVID-19;Creativeness;Data;Data Science;Development;Disparity;Doctor of Philosophy;Drug usage;efficacious intervention;Emerging infection;Epidemic;Epidemiology;Evaluation;Faculty;Future;Goals;Health;Health behavior;health disparity;Healthcare Systems;HIV;HIV disparities;HIV Infections;HIV vaccine;Human immunodeficiency virus test;Impaired cognition;implementation questions;implementation research;implementation science;Individual;Infection;Injections;innovation;Intervention;Leadership;lens;low and middle-income countries;Mental Health;Methods;Minority Groups;Monoclonal Antibodies;multidisciplinary;Needles;next generation;Outcome;pandemic disease;Patients;Persons;Pharmaceutical Preparations;pill;Population;Populations at Risk;pre-exposure prophylaxis;Predictive Analytics;preference;prevent;Prevention;Prevention strategy;Provider;Public Health Practice;racism;Research;Research Methodology;Research Personnel;Research Support;Resources;Role;Science;Site;social health determinants;socioeconomics;structural determinants;substance misuse;substance use;success;syndemic;System;Testing;theories;Therapeutic;tool;transmission process;treatment strategy;underserved community;uptake;vaccine acceptance;Vaccines;Vaginal Ring;vulnerable community;Work;Yin

PROJECT_TITLE: The Clinical Translation (CT) Core


NIH_SPENDING_CATS: Autoimmune Disease;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE  Youth from low socioeconomic groups are at a systematic disadvantage in the provision of diabetes care, particularly diabetes technology which is associated with improvement in diabetes-specific outcomes. Thus, we urgently need studies to understand and ameliorate the persistent worsening of disparities of diabetes management and outcomes in youth from low socioeconomic backgrounds. This proposed research will (1) improve representation of diverse youth in the literature, (2) address the gap in knowledge of barriers and promoters in publicly insured youth, and (3) identify and address factors of worsening disparity in diabetes technology.

PI_NAMEs: ADDALA, ANANTA  (contact)

PROGRAM_OFFICER_NAME: THORNTON, PAMELA L

PROJECT_TERMS: acceptability and feasibility;Address;Attitude;Award;behavioral health;brief intervention;career;Caring;Childhood;Childhood diabetes;Clinical;Clinical Trials;Communities;Continuous Glucose Monitor;Data;Databases;design;Development;diabetes management;Diabetes Mellitus;Disadvantaged;Disparity;disparity reduction;efficacy evaluation;Endocrinology;Epidemiology;Equity;ethnic minority population;Etiology;evidence base;Family;Focus Groups;Future;Goals;health disparity;implicit bias;improved;improved outcome;Inequity;innovation;Insulin-Dependent Diabetes Mellitus;interest;Intervention;intervention delivery;Knowledge;Literature;low socioeconomic status;Mentors;Mentorship;Methods;Modeling;multidisciplinary;Outcome;perceived discrimination;Phase;Physicians;practical application;promoter;Provider;provider factors;provider-level barriers;Proxy;public health insurance;Qualifying;Quality of life;racial minority population;Recommendation;Reporting;Research;Research Design;Research Methodology;Research Personnel;Scientist;skills;social;Socioeconomic Status;socioeconomics;statistics;Structure;Surveys;system-level barriers;Technology;technology intervention;Testing;therapy design;therapy development;Time;Training;Treatment Efficacy;Underrepresented Minority;Underrepresented Populations;United States;uptake;Youth

PROJECT_TITLE: Reducing Disparities in Pediatric Diabetes: Building the Evidence Base to Inform Effective Diabetes Technology Interventions in Underrepresented Minorities

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK(M1)-1-B]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Breast Cancer;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

PHR: Project Narrative / Public Health Relevance Triple negative breast cancer (TNBC) is a highly lethal form of breast cancer, that disparately affects African American (AA) compared with Caucasian American (CA) women with more than 2-fold increase in death rate in AA, even after adjusting for socioeconomic position, age at diagnosis, and treatment modalities. Recently, we discovered that this disparity may be the result of increased oncogenic activity of the YB1 gene signaling and its associated signaling pathways, which contribute to therapy resistance and the aggressiveness of TNBC tumors in AA women. Our innovative proposal has the potential to lead to new YB1-targeted treatment options, predict those patients who would benefit from these targeted approaches, and provide a biomarker for progression and therapy resistance of TNBC in AA women.

PI_NAMEs: SOSSEY-ALAOUI, KHALID  (contact)

PROGRAM_OFFICER_NAME: GREENBERG, WILLIAM A

PROJECT_TERMS: Address;Affect;African American;African American Women;Age;Animals;Area;Behavior;Biological;Biological Markers;black women;Breast Cancer cell line;Breast Cancer Patient;Breast Diseases;Cancer Death Rates;cancer health disparity;cancer stem cell;caucasian American;Chemoresistance;chemotherapy;Clinical;clinically significant;cohort;Combined Modality Therapy;Complex;Data;Data Set;Death Rate;Diagnosis;differential expression;Disease;Disease Outcome;Disparity;Disparity population;effectiveness evaluation;Environment;Ethnic Population;Formalin;General Population;Genes;Genetic;genetic manipulation;Goals;health disparity;health equity;Hospitals;Human;Immunohistochemistry;improved;In Vitro;in vivo;Incidence;innovation;Invaded;Life Style;Malignant Breast Neoplasm;Malignant neoplasm of ovary;Malignant Neoplasms;Mediating;Medical center;Modality;Molecular;Neoadjuvant Therapy;Neoplasm Metastasis;neoplastic cell;novel;Nuclear;Ohio;Oncogenic;Outcome;outcome disparities;Paraffin Embedding;Pathologic;Patients;Phenotype;Phosphorylation;Play;Population;population based;potential biomarker;predicting response;predictive marker;Primary Neoplasm;Prognosis;progression marker;public health relevance;Publishing;Race;racial disparity;racial population;Recurrence;Resistance;response;response biomarker;Role;Serine;Signal Pathway;Signal Transduction;Site;small molecule;sociodemographic factors;Socioeconomic Status;socioeconomics;standard of care;success;targeted treatment;Testing;Therapeutic;therapeutic target;therapy resistant;Tissue Embedding;transcriptomics;triple-negative invasive breast carcinoma;tumor;Tumor Biology;Tumorigenicity;Variant;Vulnerable Populations;Woman;Xenograft procedure

PROJECT_TITLE: Role of YB1 in health disparities in triple negative breast cancer

STUDY_SECTION: BMCD

STUDY_SECTION_NAME: Basic Mechanisms of Cancer Health Disparities Study Section[BMCD]