ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science

ORG_CITY: WORCESTER

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: PROJECT NARRATIVE Efforts to improve the diversity of the biomedical and behavioral research workforce are critical. This training program continues a highly successful initiative to provide opportunities for students under-represented in the biomedical sciences to gain valuable academic preparation and research experience in preparation for graduate training. By increasing the diversity of the biomedical and behavioral science workforce, the efforts of this proposal will enhance research efforts and positively impact health outcomes.

PI_NAMEs: LAPANE, KATE L;LEWIS, BRIAN C (contact)

PROGRAM_OFFICER_NAME: AKACEM, LAMEESE DANA

PROJECT_TERMS: academic preparation;academic program;Academic Training;Achievement;Admission activity;Advocacy;African American population;Award;Basic Science;Behavioral Research;Behavioral Sciences;Biological;Biomedical Research;Black American;Caliber;career;Clinical;Clinical Research;Collaborations;Communication;course development;Creativeness;Critical Thinking;Degree Completion;Development;Discipline;Disparity;Doctor of Philosophy;Doctor's Degree;Education;education research;Educational Activities;Educational Background;Enrollment;epidemiology study;Ethnic Origin;Evaluation;evidence base;Exclusion;experience;flexibility;Foundations;Funding;Future;Gender;Goals;graduate school;graduate student;Grant;hands on research;Health;Health Sciences;Hispanic Populations;improved;Individual;innovation;Institution;instrument;interest;intersectionality;Laboratories;Latino Population;Leadership;Learning;Letters;Massachusetts;matriculation;Measures;medical schools;Mentors;Modeling;novel;Outcome;Participant;Pathway interactions;pedagogical content;Population;population health;Positioning Attribute;Postbaccalaureate;Preparation;Program Description;Program Evaluation;programs;Race;Readiness;recruit;Research;research facility;Research Training;Scholars Program;Science;Scientist;Seasons;skill acquisition;skills;student training;Students;success;successful intervention;Surveys;Syndrome;Talents;Time Management;Training;Training Programs;translational pipeline;Underrepresented Populations;Underrepresented Students;United States National Institutes of Health;Universities;Writing

PROJECT_TITLE: Pathway to graduate study post-baccalaureate training program

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - D[TWD-D]


ADMINISTERING_IC: AG

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_CITY: JACKSONVILLE

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: MAYO CLINIC  JACKSONVILLE

ORG_STATE: FL

PHR: Project Narrative (3 sentences): There is a clear and immediate need for the discovery of peripheral molecular signatures linked to central disease processes, core and co-pathologies in Alzheimer’s Disease (AD), that will serve as precision medicine blood-based biomarkers for diagnostic, prognostic, theragnostic and therapeutic purposes. AD is a complex disorder in which many biological pathways are disrupted due to multi-omic perturbations, which can be detected in brain and reflected in blood, i.e. centrally-linked peripheral molecular signatures (CLPMS). This U19 will leverage deeply phenotyped, longitudinal NIH-funded multi-ethnic cohorts and cross-disciplinary expertise for multi-omics data generation and its integration with harmonized AD endophenotypes, will share these data and utilize them in integrated U19 projects to discover CLPMS that will serve as the next generation of AD biomarkers.

PI_NAMEs: CARRASQUILLO, MINERVA MARIA;ERTEKIN-TANER, NILUFER  (contact);NHO, KWANGSIK TIMOTHY;SAYKIN, ANDREW J

PROGRAM_OFFICER_NAME: ARUNKUMAR, NANDINI

PROJECT_TERMS: Acceleration;African American;Aging;Alzheimer's Disease;Alzheimer's Disease Pathway;Alzheimer’s disease biomarker;American;Amyloid beta-Protein;Autopsy;Biological;Biological Markers;biomarker discovery;biomarker validation;Blood;Blood specimen;blood-based biomarker;Brain;brain cell;Brain region;Cell Nucleus;cell type;Cerebrospinal Fluid;Clinic;Clinical;clinical biomarkers;clinical phenotype;Clinical Research;Cognitive;cohort;Collection;Communities;comorbidity;Complex;Data;Data Set;data sharing;Diagnosis;Diagnostic;diagnostic biomarker;Discipline;Disease;Disease Progression;DNA Methylation;Education and Outreach;endophenotype;Environment;Epigenetic Process;Ethnic Population;Functional disorder;Funding;Future;Generations;Genetic;Image;Impaired cognition;Individual;insight;Institution;Knowledge;Latino;Link;lipidome;Liquid substance;Measures;metabolome;Molecular;Molecular Profiling;multi-ethnic;multidimensional data;multimodality;Multiomic Data;multiple omics;Nerve Degeneration;neuroimaging;neuropathology;new therapeutic target;next generation;Not Hispanic or Latino;Office of Administrative Management;Onset of illness;open data;Outcome;Participant;Pathologic;Pathology;Pathway interactions;Pattern;Peripheral;Phenotype;Population;precision medicine;predictive signature;Process;Prognosis;prognostic;Prognostic Marker;Proteome;Public Health;Publishing;recruit;Research;Resources;Sampling;specific biomarkers;targeted treatment;tau Proteins;Therapeutic;therapeutic target;transcriptome sequencing;transcriptomics;Translations;trial readiness;Underrepresented Populations;United States National Institutes of Health;Validation;validation studies;Vascular Diseases;Work

PROJECT_TITLE: Centrally-linked longitudinal peripheral biomarkers of AD in multi-ethnic populations


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Data Science;Dementia;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research

PI_NAMEs: ERTEKIN-TANER, NILUFER  (contact)

PROJECT_TERMS: Acceleration;Accountability;African American;African American population;Aging;Agreement;Algorithms;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease therapeutic;Alzheimer’s disease biomarker;American;Autopsy;Biological Markers;Blood;Blood specimen;Blood Vessels;Brain;candidate marker;career;Cell Nucleus;Cerebrospinal Fluid;Clinic;cohort;Collaborations;Communication;Communities;Complex;Data;data integration;Data Set;data sharing;Dementia;Diagnostic;Discipline;Disease;DNA Methylation;Education and Outreach;endophenotype;Ensure;epigenome;Ethnic Population;Etiology;Feedback;Funding;Future;Generations;Goals;Hematological Disease;Indiana;Individual;insight;Institution;Institutional Review Boards;Knowledge;Knowledge Portal;Latino;Leadership;Link;lipidome;material transfer agreement;Medicine;meetings;metabolome;Michigan;Molecular;Molecular Profiling;multi-ethnic;Multiomic Data;multiple omics;neuroimaging;neuropathology;next generation;Not Hispanic or Latino;open data;Outcome;outreach;Participant;Peripheral;Phenotype;prognostic;programs;Proteome;repository;Reproducibility;Research;Research Personnel;resilience;Resources;Sampling;Scholars Program;Scientist;success;symposium;Training;Training Programs;transcriptome;transcriptome sequencing;trial readiness;Underrepresented Populations;United States National Institutes of Health;Universities;Washington;Work;working group

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Data Science;Dementia;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Neurodegenerative;Racial and Ethnic Minority Health Research

PI_NAMEs: ALLEN, MARIET  (contact)

PROJECT_TERMS: Address;African American;Age;American;Autopsy;Biological;Biological Markers;Blood;Brain;brain tissue;Clinic;Clinical;cohort;Collaborations;Collecting Tube;Collection;Communication;Communities;Consultations;Data;Data Collection;data collection site;data harmonization;data sharing;design;DNA Methylation;Documentation;Ethnic Origin;Ethnic Population;Generations;Genotype;Goals;Image;Indiana;Individual;innovation;Knowledge Portal;Latino;Link;lipidome;Measures;metabolome;Metadata;Michigan;Molecular;Molecular Profiling;multi-ethnic;Multiomic Data;Not Hispanic or Latino;open data;Outcome;Participant;Pathology;Peripheral;Phenotype;Plasma;Population;Population Heterogeneity;Process;programs;Proteome;Protocols documentation;Randomized;repository;Research;Research Design;Research Personnel;sample collection;Sampling;Serum;Services;sex;single nucleus RNA-sequencing;Site;Specialist;Testing;Time;Tissues;transcriptome sequencing;United States National Institutes of Health;Universities;Washington;Work

PROJECT_TITLE: Omics Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Biotechnology;Brain Disorders;Clinical Research;Data Science;Dementia;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Prevention

PI_NAMEs: NHO, KWANGSIK TIMOTHY (contact)

PROJECT_TERMS: advanced system;Alzheimer's Disease;Alzheimer's disease risk;Alzheimer’s disease biomarker;Amyloid;Amyloid beta-Protein;Autopsy;Biological Markers;Biometry;Blood;Brain;brain tissue;Calibration;cerebrovascular;Clinical;Cognition;Cognitive;cohort;Communities;Complex;Computational Biology;computerized data processing;Computing Methodologies;Data;Data Analyses;data analysis pipeline;data framework;data harmonization;data integration;data mining;data visualization;Databases;deep learning;Deposition;Development;Diffusion Magnetic Resonance Imaging;Disease Progression;DNA Methylation;Documentation;endophenotype;Environment;Ethnic Population;fluorodeoxyglucose positron emission tomography;Functional Magnetic Resonance Imaging;Genetic;genetic association;Genetic study;Genetic Transcription;genome wide association study;Genotype;Goals;high dimensionality;high throughput analysis;Image;Institution;interoperability;Link;lipidomics;Magnetic Resonance Imaging;Measures;metabolomics;method development;Methods;Molecular;Molecular Profiling;multi-ethnic;multidimensional data;multidisciplinary;multimodal neuroimaging;multimodality;Multiomic Data;multiple omics;Nerve Degeneration;Neurofibrillary Tangles;neuroimaging;neuropathology;novel;Pathway Analysis;Peripheral;phenome;Phenotype;phenotypic data;polygenic risk score;Positron-Emission Tomography;Process;Proteomics;Research Personnel;Rest;Risk;risk prediction;risk stratification;Sampling;Science;Senile Plaques;Standardization;System;Systems Biology;tau Proteins;Team Process;Tissues;transcriptome sequencing;Visualization;whole genome;Work

PROJECT_TITLE: Analytics Core


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: NEW YORK

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: PROJECT NARRATIVE Though anti-Black racism has been identified as a main driver of perinatal health inequities, no studies have examined how racism experienced at both the individual and structural levels interact to produce preterm birth. In addition, examination of how stressors such as racism affect the epigenome of Non-Hispanic Black women is similarly understudied and essential for guiding interventions to reduce health inequities. The proposed study addresses a key theme of the National Institute of Health’s strategic plan (understanding biological, behavioral, and social determinants of population health) by examining how epigenomic changes may mediate the association between racism and preterm birth.

PI_NAMEs: BARCELONA, VERONICA  (contact)

PROGRAM_OFFICER_NAME: ILEKIS, JOHN V

PROJECT_TERMS: 37 weeks gestation;Address;adverse birth outcomes;adverse outcome;Affect;Behavioral;Biological;Birth;Black race;black women;Blood;Blood specimen;Candidate Disease Gene;Climate;cohort;comparison group;Data;Discrimination;DNA;DNA Methylation;early pregnancy;Ensure;Epigenetic Process;epigenome;epigenome-wide association studies;epigenomics;Equity;ethnic disparity;Ethnic Population;experience;Exposure to;Future;Gene Expression;Genes;Genomic Segment;Geographic Locations;Goals;Health;health inequalities;Health Policy;High Risk Woman;Hispanic;Hispanic Women;Home;Immigrant;improved;Income;Individual;Infant;Intervention;Knowledge;long-term sequelae;Longitudinal cohort study;Longitudinal Studies;Maps;Maternal Health;maternal stress;Measures;Mediating;Methylation;methylation biomarker;methylome;Modeling;molecular marker;Mothers;multidisciplinary;multiple omics;Not Hispanic or Latino;novel;Nulliparity;Outcome;Ownership;Participant;Pathway interactions;perceived discrimination;Perinatal;perinatal health;perinatal morbidity;Perinatal mortality demographics;Persons;Phenotype;Policy Developments;Politics;population health;Pregnancy;Pregnancy Complications;Pregnant Women;Premature Birth;prenatal;prenatal exposure;Prevention;prospective;Race;racial disparity;racial population;racism;Research;residential segregation;Risk;Risk Factors;Services;Site;social determinants;Societies;Strategic Planning;Stress;stressor;Structural Racism;Subgroup;Tissues;United States;United States National Institutes of Health;White Women;Woman;women of color;Women's cohort;women's outcomes

PROJECT_TITLE: Epigenomic Pathways from Racism to Preterm Birth

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-A(90)S]


ADMINISTERING_IC: VA

FUNDING_MECHANISM: OTHERS

IC_NAME: Veterans Affairs

ORG_CITY: SAN FRANCISCO

ORG_NAME: VETERANS AFFAIRS MED CTR SAN FRANCISCO

ORG_STATE: CA

PHR: More than 55,000 Veterans are living with a cardiovascular implantable electronic device (CIED): pacemaker or implantable cardioverter-defibrillator, which include 1 to 3 implanted cardiac leads. Unfortunately, hundreds of thousands of CIED leads have been recalled because of high failure risk. These recalls have occurred too late, spurred only by adverse event reports after patients suffered consequences such as inappropriate shocks and even death. There is no surveillance system to identify failing CIED leads. Through this research, population-level analyses will be conducted to identify CIED lead models with the lowest failure risk; these data will inform an intervention to support VA physicians in implanting the safest leads in Veterans. This research will also create a system to predict which lead(s) currently implanted in individual Veterans are at risk for early failure, thereby informing strategies to mitigate risk. Overall, this research will improve safety by reducing the number of Veterans who suffer CIED lead failure, thereby helping Veterans live longer with better quality of life.

PI_NAMEs: DHRUVA, SANKET S (contact)

PROJECT_TERMS: Academic Detailing;Address;adjudication;Adverse event;adverse outcome;Anxiety;Area Under Curve;Arrhythmia;Assessment tool;Biometry;Calibration;California;Cardiac;cardiac device;cardiac implant;Cardiovascular Diseases;Cardiovascular system;career development;Cause of Death;Cessation of life;Clinical;comparative;Complex;Data;Data Analytics;Data Science;Data Set;Data Sources;data warehouse;Development;Device Safety;Devices;Discrimination;Elasticity;Electronic Health Record;Electronics;Evaluation;Event;experience;Failure;Feedback;follow-up;Future;Goals;Health;Health Services;Healthcare Systems;Implant;Implantable Defibrillators;implantation;implementation science;implementation strategy;improved;improved outcome;Individual;individual patient;Information Systems;innovation;Intervention;Interview;Knowledge;Lead;Learning;Life;Link;longitudinal database;machine learning method;Malignant - descriptor;Mandatory Programs;Manufacturer;Measures;Mechanics;Medicare;Medicine;Mentors;Methodology;Modeling;Monitor;novel;Pacemakers;Pain;Patient risk;Patients;Persons;Physicians;Pilot Projects;Population;post intervention;predictive modeling;prevent;Probability;professor;programs;prospective;Publications;Publishing;Qualitative Methods;Quality of Care;Quality of life;random forest;Registries;remote monitoring;Repeat Surgery;Reporting;Research;Research Personnel;Resources;Risk;Risk Adjustment;Risk Assessment;risk mitigation;risk prediction model;Role;Safety;San Francisco;Shock;Signal Transduction;skills;Statistical Methods;statistics;Stress;supervised learning;Surveillance Program;Survival Analysis;System;Techniques;Training;Translating;transmission process;United States Food and Drug Administration;Universities;Veterans

PROJECT_TITLE: Improving Safety of Cardiovascular Implantable Electronic Devices in Veterans

STUDY_SECTION_NAME: Research Career Scientist[MRA0]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Neurodegenerative;Neurosciences;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research

PROJECT_TERMS: advanced analytics;African American;Aging;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease pathology;Alzheimer's disease related dementia;Alzheimer’s disease biomarker;American;artificial neural network;Autopsy;Biological;Biological Markers;biomarker discovery;Blood;Blood specimen;Blood Vessels;blood-based biomarker;Brain;brain cell;Brain region;Cell Nucleus;cell type;Cerebrospinal Fluid;Clinic;Clinical;Cognition;Cognitive;cohort;Collaborations;Communities;comparative;Complex;cost effective;Data;Diagnosis;Diagnostic;Disease;disease phenotype;Disease Progression;disorder subtype;Early Diagnosis;epigenetic clock;Epigenetic Process;Ethnic Population;Florida;Functional disorder;Future;Gene Expression Profile;Genes;Genetic;Genome;Image;Individual;Knowledge;Latino;Link;lipidome;Longitudinal cohort;Measures;metabolome;methylome;Molecular;Molecular Profiling;multi-ethnic;Multiomic Data;multiple omics;myelination;Natural Immunity;neuroimaging;neuropathology;novel;Outcome;Participant;Pathway Analysis;Pathway interactions;patient stratification;Pattern;Peripheral;peripheral blood;personalized medicine;Phenotype;Population;Population Heterogeneity;precision medicine;preservation;prognostic;Proteins;Proteome;random forest;Resources;RNA;Sampling;single nucleus RNA-sequencing;Symptoms;Synapses;Testing;Therapeutic;Therapeutic Intervention;Transcript;transcriptome;transcriptome sequencing;transcriptomic profiling;translational approach;translational study;Translations;validation studies

PROJECT_TITLE: Discovering Centrally Linked Peripheral Molecular Signatures of Alzheimer's Disease


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: ATLANTA

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE This project will determine the contribution of the gut microbiome to mechanism of action of parathyroid hormone in bone. Our study will provide evidence that that primary hyperparathyroidism causes osteoporosis only in mice and patients harboring specific bacterial strains in their intestinal microbiome. This is important because sequencing of the stool microbiome may be used to predict which patients affected by primary hyperparathyroidism will develop bone loss.

PI_NAMEs: BILEZIKIAN, JOHN P;JONES, RHEINALLT MELFYN;PACIFICI, ROBERTO  (contact)

PROGRAM_OFFICER_NAME: MALOZOWSKI, SAUL N

PROJECT_TERMS: Affect;antimicrobial;Bacteria;Bifidobacterium;Biological Markers;Blood;bone;Bone Density;bone loss;Bone Marrow;CCL20 gene;CCR6 gene;Cell Differentiation process;Cell Maturation;cell motility;Cell secretion;Cells;chemokine;commensal bacteria;Data;Disease;Endowment;enteric infection;Etiology;experience;FDA approved;fecal microbiome;fecal transplantation;Feces;Fracture;fracture risk;Frequencies;Future;Germ-Free;gut microbiome;Heterogeneity;Hormones;Human;Human Microbiome;Hyperparathyroidism;IL17 gene;Inflammatory;Infusion procedures;inhibitor;Intestinal Mucosa;Intestines;Lamina Propria;Ligands;Measures;Mediating;microbial;microbiome;microbiome sequencing;migration;Modeling;mouse model;Mus;Nature;novel;novel strategies;Osteocytes;Osteoporosis;Parathyroid gland;pathogen;Patients;Phenotype;Population;prevent;Process;Production;PTH gene;Reporting;Reproduction spores;Role;skeletal;Stream;Stromal Cells;T-Lymphocyte;Testing;Tissues;TNF gene;TNFSF11 gene;trafficking;Up-Regulation;Variant;Visualization

PROJECT_TITLE: Role of the gut microbiome in the bone loss induced by hyperparathyroidism in mice and humans

STUDY_SECTION: SBSR

STUDY_SECTION_NAME: Skeletal Biology Structure and Regeneration Study Section[SBSR]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Mental Illness;Neurosciences;Psychosis;Schizophrenia;Serious Mental Illness

ORG_CITY: CHICAGO

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: Project Narrative Although it is widely known that people with psychosis have reduced cognitive ability compared to their psychiatrically healthy peers, the neurobiological mechanisms that give rise to this impairment remain poorly understood. In this project we will evaluate the role of a promising candadite biomarker of working memory dysfunction—a “core” cognitive deficit commonly observed in people with psychosis. Using EEG, we will (1) isolate a core psychophysiological process involved in working memory; (2) measure the impact of psychosis and illness chronicity on this biomarker; and (3) manipulate this biomarker using neurofeedback and measure the effects of this manipulation on working memory capacity.

PI_NAMEs: ERICKSON, MOLLY  (contact)

PROGRAM_OFFICER_NAME: MORRIS, SARAH ELIZABETH

PROJECT_TERMS: Address;Attention;Award;Biological Markers;Brain;candidate marker;Chronic;Clinical;clinical biomarkers;Cognitive;cognitive ability;Cognitive deficits;Coupling;Cues;Data;design;Development;effective intervention;Effectiveness of Interventions;Electroencephalography;Etiology;Event;Exhibits;first episode psychosis;Frequencies;Functional impairment;Future;Goals;Illness impact;Impaired cognition;Impairment;improved;Individual;Intervention;Learning;Link;Literature;Maintenance;Measurement;Measures;Memory;memory consolidation;Memory impairment;memory process;memory retention;National Institute of Mental Health;neural;neurobiological mechanism;neurofeedback;novel;Participant;peer;Perception;Performance;personalized intervention;Persons;Phase;Play;Population;Process;Protocols documentation;Psychophysiology;Psychoses;Psychotic Disorders;psychotic symptoms;remediation;Research Personnel;response;Role;Series;severe mental illness;Short-Term Memory;Signal Transduction;Specificity;therapy development;Training;Validation;Variant;Visual;Work

PROJECT_TITLE: Measurement and manipulation of oscillatory biomarker of working memory in psychosis

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Biotechnology;Brain Disorders;Clinical Research;Dementia;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Machine Learning and Artificial Intelligence;Neurodegenerative;Neurosciences;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research

PI_NAMEs: SAYKIN, ANDREW J (contact)

PROJECT_TERMS: Acceleration;African;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease related dementia;Alzheimer’s disease biomarker;American;Amyloid;Artificial Intelligence;artificial intelligence model;Biological;Biological Markers;biomarker identification;Blood;Blood Vessels;Brain;brain tissue;candidate marker;causal model;cerebrovascular;Clinical;Clinical Trials;Cognition;Cognitive;cognitive change;cognitive performance;cohort;Cohort Studies;Collaborations;Communities;Coupled;Data;Data Set;Dementia;design;Diagnostic;differential expression;Disease;Disease Progression;DNA;DNA Methylation;Early Diagnosis;endophenotype;epigenetic clock;Epigenetic Process;Ethnic Population;follow-up;Functional disorder;Functional Magnetic Resonance Imaging;Funding;Future;Genes;Genetic;Genetic Transcription;genome sequencing;Goals;Heterogeneity;Immune;Immunity;Indiana;induced pluripotent stem cell;insight;Latino;Length;Link;lipidomics;Liquid substance;longitudinal analysis;Machine Learning;Magnetic Resonance Imaging;metabolomics;Modality;Modeling;Molecular;Molecular Profiling;multi-ethnic;Multimodal Imaging;multimodal neuroimaging;Multiomic Data;multiple omics;Mus;myelination;Nerve Degeneration;neuroimaging;novel;open data;Outcome;Participant;Pathway interactions;Patients;Peripheral;peripheral blood;polygenic risk score;Population;Positron-Emission Tomography;precision medicine;predictive marker;predictive modeling;Process;Proteomics;Research;Risk;RNA;Sampling;Site;Synapses;tau Proteins;telomere;Testing;Therapeutic;therapeutic biomarker;therapeutic target;Time;Transcript;transcriptome sequencing;transcriptomics;translational approach;Validation;validation studies;Variant;whole genome

PROJECT_TITLE: Longitudinal Blood-based Transcriptomic Changes in AD: Relation to Clinical and Biomarker Data


NIH_SPENDING_CATS: Neurosciences

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: The proposal seeks to define the mechanism by which voltage changes activate ion conducting channels, a fundamental system in neurobiology, by determining atomic structures that enable therapeutic approaches to regulate ion channels in the lysosome, of impact in Ebola and viral infection. It also seeks to determine how regulatory complexes and their structural interfaces control uric acid transport in the endolysosome, to play a key factor in neurodegeneration, cancers, metabolic and cardiovascular diseases, that each depend on endolysosomal trafficking. A second set of aims concern determining the fundamental basis for the transmembrane transport of essential nutrients, particularly phosphate and glucose into, and removal of uric acid from cells, providing an atomic structural roadmap for therapeutic intervention in cancers, neurodegenerative diseases and malignant melanomas.

PI_NAMEs: STROUD, ROBERT M (contact)

PROGRAM_OFFICER_NAME: TAYLOR, VERONICA

PROJECT_TERMS: Alzheimer's Disease;Amaze;Amino Acid Sequence;Automobile Driving;Autophagocytosis;Binding;Cardiovascular Diseases;Cell membrane;Cell Survival;Cells;Chemicals;Complex;Coupled;Coupling;crosslink;Cryoelectron Microscopy;Cysteine;Dependence;design;Development;Disease;drug development;Ebola;Electrophysiology (science);Engineering;Erythrocytes;Eukaryotic Cell;Excision;genetic variant;Glucose;Glucose Transporter;Goals;Gout;Growth;Human;Hyperactivity;Hyperuricemia;Individual;inhibitor;inorganic phosphate;Inorganic Phosphate Transporter;Integral Membrane Protein;Ion Channel;Ion Channel Gating;Ion Transport;Ions;Link;Lysosomal Storage Diseases;Lysosomes;Malignant Neoplasms;Maps;Mass Spectrum Analysis;Measures;Melanoma;Membrane;Membrane Proteins;Membrane Transport Proteins;Metabolic Diseases;Modeling;Molecular;Molecular Conformation;monomer;Motion;Movement;Mutagenesis;mutant;Mutation;Nerve Degeneration;Neurobiology;Neurodegenerative Disorders;Neurons;neurotransmission;Nuclear;Nutrient;Pathway interactions;Pattern;Pharmaceutical Preparations;Physiology;Plants;Play;Poison;Process;Property;prospective;Proteins;Protons;Recycling;Regulation;Research;Resolution;response;Rest;Risk;Roentgen Rays;Role;Rotation;sensor;Signal Transduction;simulation;Sister;SLC2A1 gene;Slide;Structure;symporter;System;Therapeutic;Therapeutic Intervention;Time;trafficking;Transducers;Transmembrane Domain;Transmembrane Transport;Travel;Uric Acid;Virus Diseases;Visualization;voltage;X-Ray Crystallography

PROJECT_TITLE: Molecular Basis for Transmembrane Conduction & Signaling

STUDY_SECTION: BBM

STUDY_SECTION_NAME: Biochemistry and Biophysics of Membranes Study Section[BBM]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Human Genome;Immunotherapy;Lung;Lung Cancer

ORG_CITY: BOSTON

ORG_NAME: DANA-FARBER CANCER INST

ORG_STATE: MA

PHR: Project Narrative Genomic analysis of plasma circulating tumor DNA has been adopted widely for genotyping of advanced cancer to select targeted therapies. This noninvasive biomarker also offers clear potential for evaluating treatment response, though no rigorous criteria have been established for determining when to assess response in plasma, and how much change is meaningful. In this grant we will identify a criterion for plasma response and evaluate its utility in clinical trial analysis and in guiding the care of lung cancer patients receiving first-line immunotherapy.

PI_NAMEs: PAWELETZ, CLOUD PETER (contact)

PROGRAM_OFFICER_NAME: OSSANDON, MIGUEL

PROJECT_TERMS: Address;Adopted;Advanced Malignant Neoplasm;Biological;Biological Assay;Biological Markers;Biopsy;Blood;Blood Tests;cancer care;cancer imaging;Cancer Patient;cancer therapy;Caring;chemotherapy;Clinical;clinical application;clinical trial analysis;Clinical Trials;cohort;Communities;Complement;Dana-Farber Cancer Institute;Data;Development;Diagnostic;DNA analysis;Drug resistance;Drug Targeting;effective therapy;Effectiveness;Epidermal Growth Factor Receptor;experience;FDA approved;Generations;Genomics;Genotype;Grant;Image;Immuno-Chemotherapy;Immunotherapy;improved;innovation;insight;Institution;Intuition;Investigational Therapies;KRAS2 gene;liquid biopsy;Malignant neoplasm of lung;Malignant Neoplasms;Measurement;Measures;Methods;Molecular;Monitor;mutant;Mutation;Nature;next generation sequencing;Non-Small-Cell Lung Carcinoma;novel diagnostics;novel therapeutics;Oncogenes;Oral;Outcome;Patient Care;Patients;pembrolizumab;Performance;Pharmaceutical Preparations;Plasma;Positioning Attribute;radiological imaging;Research Personnel;response;response biomarker;ROS1 gene;Specimen;targeted treatment;Testing;Therapeutic Trials;tool;Translating;treatment effect;Treatment outcome;treatment response;tumor;tumor DNA;Validation;Variant

PROJECT_TITLE: Early change in plasma tumor DNA as a patient and trial-level diagnostic in advanced lung cancer

STUDY_SECTION: CONC

STUDY_SECTION_NAME: Clinical Oncology Study Section[CONC]


PI_NAMEs: CARRASQUILLO, MINERVA MARIA (contact)

PROJECT_TERMS: Address;African American;African American population;Alcohol consumption;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease patient;Alzheimer's disease risk;Alzheimer’s disease biomarker;American;Amyloid;Autopsy;Biological;Biological Markers;Biomedical Research;Blood;Blood specimen;Blood Vessels;Brain;California;cerebrovascular;Characteristics;Clinic;Clinical;clinical diagnosis;Clinical Trials;Cognition;Cognitive;cohort;Cohort Analysis;Collection;Community Outreach;comorbidity;comparative;Data;data analysis pipeline;data archive;Dementia;dementia risk;Development;Diabetes Mellitus;Diagnosis;diagnostic biomarker;differential expression;Disease;Disease Progression;Disparity;Education;endophenotype;Epigenetic Process;Ethnic Population;Evaluation;Exhibits;Frequencies;Funding;Genes;Genetic;Genetic Risk;genetic variant;Genetic Variation;genomic locus;Genotype;Goals;High Prevalence;Hypertension;image archival system;Impaired cognition;improved;Incidence;Indiana;Individual;Institution;Knowledge;Latino;lifestyle factors;Link;longitudinal analysis;Measures;Methylation;methylome;Michigan;mild cognitive impairment;minimally invasive;Molecular;Molecular Profiling;multi-ethnic;Multiomic Data;multiple omics;Nerve Degeneration;neuroimaging;neuron loss;Not Hispanic or Latino;novel;outreach program;Participant;Pathway interactions;Pattern;Peripheral;Phenotype;Plasma;polygenic risk score;Population;potential biomarker;precision medicine;predictive marker;preventive intervention;Preventive therapy;Prognostic Marker;recruit;Research;research study;Resources;risk variant;sample collection;Sample Size;Sampling;Sensitivity and Specificity;Smoking;Subgroup;tau Proteins;Testing;therapy design;therapy development;Time;Transcript;transcriptome;transcriptome sequencing;transcriptomics;Translations;trial readiness;Underrepresented Populations;Universities;Validation;whole genome

PROJECT_TITLE: Peripheral and Central Biomarkers of Alzheimer's Disease in Diverse Cohorts


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Prevention;Prostate Cancer;Racial and Ethnic Minority Health Research;Urologic Diseases

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: Project Narrative At present, it is not known how the prostate cancer metabolome contributes to health disparities. The information gleaned from this proposal could rapidly revolutionize current diagnostic, prognostic, and therapeutic approaches by revealing the biological underpinnings of prostate cancer health disparity. This proposal investigates how altered metabolism in African-American Prostate Cancers promotes tumor progression and how the knowledge can be used in the future to develop diet based interventions and early detection markers for African American men.

PI_NAMEs: RUSTVELD, LUIS ;SREEKUMAR, ARUN  (contact)

PROGRAM_OFFICER_NAME: SNYDERWINE, ELIZABETH G

PROJECT_TERMS: Address;African American;African ancestry;Age;American;Area Under Curve;beef;Benign;Biological;Biological Factors;Biological Markers;biomarker panel;Biopsy;bone;cancer biomarkers;cancer health disparity;Cardiovascular Diseases;case control;cell growth;Cells;Chickens;Clinical;clinically significant;cofactor;college;Consumption;cooking;Cystathionine beta-Synthase;Data;Data Set;Diagnosis;Diagnostic;Diet;Diet Modification;Dietary Practices;Disparity;early detection biomarkers;Enzymes;epidemiologic data;Epidemiologic Factors;Epidemiology;European;Exhibits;Fishes;follow-up;Food;Future;gain of function;Genes;Genetic;Glean;Growth and Development function;health disparity;healthy lifestyle;high risk;high risk men;High temperature of physical object;Homocysteine;In Vitro;in vivo;Incidence;Intake;Intervention;Knowledge;lifestyle intervention;Link;LNCaP;loss of function;Malignant neoplasm of prostate;Mass Spectrum Analysis;Meat;Medicine;men;Metabolic;Metabolism;metabolome;Metastatic Neoplasm to the Bone;Methionine;Methods;Modeling;Molecular;mortality;National Health and Nutrition Examination Survey;Neoplasm Metastasis;Non-Invasive Detection;Odds Ratio;Organ;Pathologic;Pathway interactions;Patients;Plasma;population based;Population Study;Processed Meats;prognostic;prostate biopsy;prostate cancer cell;prostate cancer progression;prostate cancer risk;Prostate-Specific Antigen;Prostatic Diseases;Prostatic Neoplasms;PSA level;Publishing;Race;racial difference;Research;Risk;risk mitigation;Role;saturated fat;Screening for Prostate Cancer;Side;socioeconomics;Supplementation;Tenascin;Testing;Therapeutic;Time;Tissues;Training;Transcript;Transforming Growth Factor beta;tumor;tumor progression;Tumor Promotion;Vitamin B6;Work;Xenograft Model

PROJECT_TITLE: Elevated homocysteine in African American Prostate Cancer: Association with Diet and Dietary practices, evaluating its biomarker potential, and characterizing its tumor promoting function

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OBT-Y(55)R]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Neurosciences;Opioids;Substance Misuse;Tobacco

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PI_NAMEs: BRUCHAS, MICHAEL R. (contact)

PROGRAM_OFFICER_NAME: BERTON, OLIVIER

PROJECT_TERMS: Alcohols;Amygdaloid structure;Anxiety;Behavior;Behavioral;Behavioral Model;Biological;Brain;Calcium;calmodulin-dependent protein kinase II;Cartoons;cell type;Cells;Cessation of life;Chemosensitization;Claustral structure;Clustered Regularly Interspaced Short Palindromic Repeats;Cocaine;Corpus striatum structure;Dependovirus;Dorsal;Drug abuse;drug of abuse;Drug Regulations;drug seeking behavior;Dynorphins;Electrophysiology (science);endogenous opioids;Enterobacteria phage P1 Cre recombinase;experience;experimental study;gain of function;Genetic;genetic approach;Glutamates;Heroin;Hippocampus;Image;in vivo;in vivo calcium imaging;Instruction;interdisciplinary approach;kappa opioid receptors;lead candidate;Learning;Ligands;Link;Measures;Mediating;Memory;Methods;microendoscopy;Modeling;Mood Disorders;Motivation;mouse genetics;mouse model;Mus;neural circuit;Neurons;Neuropharmacology;Nicotine;Nicotine Dependence;nicotine reward;nicotine seeking behavior;nicotine self-administration;nicotine treatment;nicotine use;novel therapeutic intervention;Nucleus Accumbens;Opiate Addiction;Opioid;Opioid agonist;Opioid Peptide;Opioid Receptor;optogenetics;Outcome;parabrachial nucleus;Pharmaceutical Preparations;pharmacologic;Pharmacology;Photometry;Play;preference;presynaptic;Process;receptor;Receptor Activation;receptor expression;recruit;Regulation;Relapse;Reporting;Rewards;Risk;Role;Satellite Viruses;Self Administration;Site;Slice;Stress;Synapses;Synaptic plasticity;System;Testing;Therapeutic Intervention;Time;Tobacco;Ventral Striatum;Viral;viral rescue;Work

PROJECT_TITLE: DISSECTING DYNORPHIN-KAPPA OPIOID MEDIATED REINSTATEMENT OF NICOTINE PREFERENCE

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Neurosciences

ORG_CITY: AUSTIN

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

PHR: PROJECT NARRATIVE The ability to listen selectively in everyday environments like noisy restaurants, classrooms, and workplaces is essential to communication. Its disruption significantly diminishes quality of life in many communication, developmental, neurological, and psychiatric disorders. The project examines the mechanisms underlying human adult listeners' ability to direct attention to specific dimensions of sound.

PI_NAMEs: HOLT, LORI L (contact)

PROGRAM_OFFICER_NAME: KING, KELLY ANNE

PROJECT_TERMS: Acoustics;Adopted;Adult;Affect;Animal Experimentation;Animals;Attention;Auditory;Auditory area;auditory pathway;Automobile Driving;Behavior;Behavioral;behavioral outcome;Biological Assay;Characteristics;Clinical;Cognitive;Communication;Communication impairment;Complex;Coupled;Crowding;Developmental Communication Disorders;developmental disease;Dimensions;directed attention;Disease;Electrophysiology (science);Employment Opportunities;Environment;Equilibrium;Event;evidence base;expectation;Frequencies;Friends;Future;Goals;Grain;Human;Impairment;improved;innovation;Learning;lectures;Life;Literature;Magnetic Resonance Imaging;Maps;Measures;meetings;member;Mental Depression;Mental disorders;Modeling;Molecular;multimodality;myelination;Nervous System Disorder;neurobiological mechanism;Neurobiology;Neurodegenerative Disorders;neuroimaging;Neurologic;neuromechanism;Noise;novel strategies;Persons;Play;prevent;Process;Psychophysics;Quality of life;remediation;Research;Resolution;Restaurants;Risk;Schools;selective attention;Shapes;Signal Transduction;Social isolation;sound;Source;Speech;Stimulus;Stroke;Testing;theories;tool;Training;Traumatic Brain Injury;Work;Workplace

PROJECT_TITLE: Behavioral outcomes and neurobiological mechanisms of sustained auditory selective attention

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


ORG_CITY: LOS ANGELES

ORG_NAME: VA GREATER LOS ANGELES HEALTHCARE SYSTEM

PHR: Atrial fibrillation (AF) is an increasingly common heart rhythm disorder, affecting nearly 1 million Veterans engaged in VA health care. AF is associated with an increased risk of stroke, heart failure, and hospitalization, and results in substantial medical and societal costs. Although oral anticoagulant therapy reduces the risk of stroke from AF by 60%, it is often underutilized, particularly for racial and ethnic minorities who have an even higher risk of this adverse outcome. These inequities are particularly pronounced for a newer class of direct oral anticoagulants (DOACs) – which have greater effectiveness, safety, and adherence compared to traditional warfarin anticoagulation. This project will use quantitative and qualitative research to understand the multilevel determinants of racial and ethnic disparities in anticoagulant therapy initiation for Veterans with AF and use the findings to empirically develop and test implementation strategies to reduce or eliminate these well-documented disparities.

PI_NAMEs: ESSIEN, UTIBE R. (contact)

PROJECT_TERMS: Address;Adherence;Administrator;Adult;adverse outcome;Affect;Aging;Anticoagulant therapy;Anticoagulants;Anticoagulation;Area;Arrhythmia;Atrial Fibrillation;Attenuated;Award;black patient;Cardiovascular Diseases;Cardiovascular system;care outcomes;career;Caring;Chronic;Clinic;Clinical;cohort;Consolidated Framework for Implementation Research;cost;Data Sources;Death Rate;design;Detection;Disease;Disparity;disparity elimination;disparity reduction;effective therapy;Effectiveness;effectiveness evaluation;effectiveness testing;Ensure;Equitable healthcare;Equity;ethnic disparity;ethnic health disparity;ethnic minority;Ethnic Origin;evidence base;experience;feasibility testing;Foundations;Frequencies;Goals;health care disparity;health equity;Health equity research;Health Services;Health Services Research;Healthcare;Heart failure;heart rhythm;high risk;Hispanic;Hospitalization;Hybrids;implementation design;implementation science;implementation strategy;improved;Individual;Inequity;innovation;Internist;Interview;K-Series Research Career Programs;Leadership;Medical;Medical Care Costs;medical specialties;medication safety;Mentors;Methodology;Methods;military veteran;Minority;Minority Groups;Modeling;Monitor;mortality;Neighborhoods;Newly Diagnosed;novel;Oral;Participant;Patients;Perception;pilot test;primary care practice;Provider;Qualitative Research;Race;racial determinant;racial disparity;racial minority;recruit;Research;Research Personnel;Research Support;Risk Reduction;Safety;Sampling;Site;societal costs;sociodemographic factors;Socioeconomic Status;Specific qualifier value;stroke risk;Testing;tool;Training;Training Support;treatment disparity;United States;Variant;Veterans;Warfarin;Work

PROJECT_TITLE: Access, Quality and Equity of Anticoagulants in Veterans with Atrial Fibrillation


ADMINISTERING_IC: AA

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Cardiovascular;Heart Disease;Natural Products;Prevention;Substance Misuse

ORG_CITY: COLUMBIA

ORG_NAME: ACEPRE, LLC

ORG_STATE: SC

PHR: Project Narrative: Alcoholic Cardiomyopathy (ACM) is the most prevalent form of ethanol-induced heart damage. There are currently no FDA-approved therapies for ACM. We propose to develop a pleiotropic natural compound emodin as a therapy for the prevention and treatment of ACM.

PI_NAMEs: CARVER, WAYNE E (contact);FAN, DAPING

PROGRAM_OFFICER_NAME: LIN, LI

PROJECT_TERMS: Alcohol abuse;alcohol abuse therapy;Alcohol consumption;alcohol testing;Alcoholic Cardiomyopathy;Alcohols;Anatomy;Animal Model;Anti-Inflammatory Agents;Apoptosis;Apoptotic;Area;Arrhythmia;Attenuated;Autocrine Communication;Basic Science;Blood;Body Weight;capsule;Cardiac;Cardiac Myocytes;cell type;Cessation of life;Chronic;chronic alcohol ingestion;commercialization;coronary fibrosis;Cyclic GMP;Data;Data Reporting;Development;Dilatation - action;Disease;dosage;Dose;Doxorubicin;drug development;Drug Kinetics;effective therapy;efficacy study;Emodin;Ethanol;Family suidae;FDA approved;feeding;Fibroblasts;Formulation;Functional disorder;Funding;Future;Goals;Heart;heart damage;Heart failure;Hepatotoxicity;Human;Inbred BALB C Mice;inhibitor;kidney dysfunction;Literature;Liver;Liver Dysfunction;Malignant Neoplasms;manufacture;Metabolism;Modeling;mouse model;Mus;Myocardial;Myocardial dysfunction;Myocarditis;Natural Compound;Necrosis;novel therapeutics;Oral;Organ;Paracrine Communication;Pathogenesis;Pathology;Pharmaceutical Preparations;Phase;phase 1 study;phase 2 study;preclinical study;prevent;Prevention;Prevention therapy;Preventive;Process;programs;Rattus;Rodent Model;Safety;safety study;Signal Transduction;Small Business Technology Transfer Research;small molecule;Surface;Testing;Therapeutic;Therapeutic Agents;Toxic effect;Transforming Growth Factor beta;translation to humans;Ventricular;Wistar Rats

PROJECT_TITLE: Developing natural compound emodin as a therapy for alcoholic cardiomyopathy


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: CLEMSON

ORG_DEPT: GENETICS

ORG_NAME: CLEMSON UNIVERSITY

PHR: PROJECT NARRATIVE Common and rare genetic diseases affect a large fraction of the world’s population, but the causal genetic variants affecting disease risk and the mechanisms by which they affect disease remain largely unknown. We will establish a Center of Biomedical Research Excellence (COBRE) in Human Genetics that constitutes a unique partnership between the Clemson University Center for Human Genetics and the Greenwood Genetic Center. Research in the COBRE in Human Genetics will focus on understanding the genetic, genomic, and epigenetic mechanisms by which molecular genetic variation affects rare and common diseases and will strengthen the biomedical research infrastructure of Clemson University and the state of South Carolina.

PI_NAMEs: ANHOLT, ROBERT R. H;MACKAY, TRUDY F. (contact)

PROGRAM_OFFICER_NAME: BASKIR, RUBIN SAM

PROJECT_TERMS: Advisory Committees;Affect;Animal Model;animal model development;Animals;Assistantship;Award;Bioinformatics;Biological Models;Biomedical Research;candidate identification;causal variant;Cell Culture Techniques;Cells;Cellular biology;Centers of Research Excellence;Collaborations;Complement;Complex;Computational Biology;Core Facility;Data;Development;Developmental Biology;developmental genetics;Diagnosis;dimensional analysis;Disease;disease phenotype;disorder risk;Epigenetic Process;Evaluation;exome sequencing;Extramural Activities;Face;Faculty;forward genetics;functional genomics;Funding;Future;Gene Expression Regulation;Genetic;genetic information;Genetic Research;Genetic Transcription;genetic variant;Genetic Variation;genome sequencing;genomic data;Genomic medicine;Genomics;Goals;graduate student;Grant;Health;high dimensionality;Human;human disease;Human Genetics;Human Genome;Individual;innovation;Institution;Interdisciplinary Study;interest;Knowledge;Leadership;Maps;member;Mentors;Modeling;Modernization;Molecular;Molecular Genetics;multidisciplinary;nature center;neurogenetics;Patients;Phenotype;Pilot Projects;pleiotropism;Population;predictive modeling;professor;programs;Rare Diseases;rare genetic disorder;rare variant;recruit;Research;Research Activity;Research Infrastructure;Research Personnel;Research Project Grants;Research Support;Resources;Risk;risk prediction;Role;Scientist;South Carolina;Statistical Models;statistics;Structure;Symptoms;Testing;therapy development;Training;trait;United States National Institutes of Health;Universities;Untranslated RNA;Variant;whole genome

PROJECT_TITLE: COBRE in Human Genetics


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Genetics;Stem Cell Research;Stem Cell Research - Embryonic - Human

PI_NAMEs: MACKAY, TRUDY F. (contact)

PROJECT_TERMS: Accounting;Advisory Committees;Appointment;Assistantship;career;career development;Career Mobility;Centers of Research Excellence;Collaborations;college;Communities;Community Outreach;Core Facility;Development;Development Plans;early-career faculty;Educational workshop;Effectiveness;Ensure;Evaluation;experience;Extramural Activities;Faculty;formative assessment;Funding;Genetic;graduate student;Group Meetings;Growth;Growth and Development function;Human Genetics;Individual;Institution;Journals;Leadership;Learning;meetings;member;Mentors;Mentorship;Monitor;peer coaching;Performance;Phase;Pilot Projects;professor;Program Evaluation;programs;Progress Reports;Questionnaires;Recommendation;recruit;Regulation;Reproducibility;Research;Research Personnel;Research Project Grants;Resources;responsible research conduct;Science;Series;Structure;success;symposium;Training;Universities

PROJECT_TITLE: Admin-Core


ED_INST_TYPE: GRADUATE SCHOOLS

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

ORG_CITY: Princeton

ORG_DEPT: NEUROSCIENCES

ORG_NAME: PRINCETON UNIVERSITY

ORG_STATE: NJ

PHR: PROJECT NARRATIVE Accumulating evidence over time to select between alternative options is a fundamental process in decision making, but canonical models suggest that neural signatures of this process should show persistent, ramping activity, unlike the choice-selective, sequential neural firing commonly observed throughout cortical and subcortical areas. This project will develop new computational circuit models that suggest different underlying mechanisms for accumulating evidence through sequences and analyze the correspondence between these novel models and neural recordings in different brain regions at the individual neuron and population levels during the same navigation-based, accumulation of evidence task. Successful completion of this work will lead to the development of novel models which propose yet unexplored mechanisms that may underlie decision making and advance our understanding of how decision making processes are distributed and coordinated across the brain.

PI_NAMEs: BROWN, LINDSEY SHOEMAKER (contact)

PROGRAM_OFFICER_NAME: VAN'T VEER, ASHLEE VICTORIA

PROJECT_TERMS: Address;Algorithms;Animals;Anterior;Area;Base Sequence;Behavioral;Brain;BRAIN initiative;Brain region;Calcium;cingulate cortex;Code;cognitive process;computational neuroscience;Corpus striatum structure;Cues;Data;Data Analyses;data modeling;Decision Making;Development;Dimensions;Environment;evidence base;experimental analysis;experimental study;Fellowship;Fire - disasters;Foundations;geometric structure;Goals;Hippocampus;Human;Individual;insight;Institution;Knowledge;Learning;Location;Memory;Mental Processes;Modeling;Mus;Neocortex;neural;neural circuit;neural model;neuromechanism;Neurons;Neurosciences;novel;Population;Population Dynamics;Positioning Attribute;predictive modeling;Process;Ramp;Resources;response;Rewards;Side;Signal Transduction;skills;Structure;System;Task Performances;Techniques;Technology;Testing;Time;tool;Training;Travel;Visual;Visual Cortex;Work

PROJECT_TITLE: Models for accumulation of evidence through sequences in a navigation-based, decision-making task


ADMINISTERING_IC: LM

IC_NAME: NATIONAL LIBRARY OF MEDICINE

ORG_CITY: PHILADELPHIA

ORG_DEPT: BIOLOGY

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

ORG_STATE: PA

PHR: Project Narrative The profiling of genome variation from hundreds to thousands of cells now provides a powerful means to study the tempo and mode of molecular evolution at the finest resolution, but there is a need for new methods to analyze such datasets effectively. We will develop new mutation-ordering phylogenetic methods for evolutionary bioinformatics analysis of cell sequencing data. These methods and their software implementations will facilitate evolutionary research pursued by basic and applied biologists.

PI_NAMEs: MIURA, SAYAKA  (contact)

PROGRAM_OFFICER_NAME: BINGHAM, CLAYTON SCOTT

PROJECT_TERMS: Bioinformatics;Biological;Cells;Charge;Collection;Compensation;Computer software;Data;Data Analyses;Data Set;Dimensions;Disease Outbreaks;Education;Evolution;Exclusion;Frequencies;frontier;Genetic Recombination;genetic variant;Genome;genomic profiling;Genomics;Genotype;Haplotypes;high throughput analysis;improved;indexing;Individual;innovation;Joints;large datasets;Libraries;method development;Methodology;Methods;Molecular;Molecular Evolution;Mutation;Mutation Analysis;novel;pathogen;Pattern;Performance;Phase;Phylogenetic Analysis;Phylogenetic Pattern;Phylogeny;Positioning Attribute;Probability;Process;programs;reconstruction;Recurrence;Research;research and development;Research Personnel;Resolution;Sequence Alignment;single cell sequencing;software development;Somatic Cell;Somatic Mutation;Source Code;Techniques;Technology;Testing;Time;tool;Training;Translating;Trees;Variant;Vertebral column

PROJECT_TITLE: Cellular Phylogenetics and Evolution

STUDY_SECTION: BLR

STUDY_SECTION_NAME: Biomedical Informatics, Library and Data Sciences Review Committee[BLR]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences

ORG_CITY: Newark

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF DELAWARE

ORG_STATE: DE

PHR: Project Narrative:  Understanding the fundamental principles governing social communication is of paramount importance as deficits in expressive and receptive vocal communication skills are hallmark characteristics of a wide range of neurological disorders. The proposed experiments aim to determine the direct impact of social communication on behavior and delineate how neural circuits encode social communication. Ultimately, knowledge gained from the proposed project has the potential to inform and hasten the discovery of novel therapeutic approaches that will help reduce the burdens of human disability.

PI_NAMEs: NEUNUEBEL, JOSHUA P (contact)

PROGRAM_OFFICER_NAME: BREEDEN, ANDREW LEE

PROJECT_TERMS: Acoustics;Adult;affiliative behavior;Agonistic Behavior;Animal Disease Models;Animals;Auditory;autism spectrum disorder;Behavior;Behavioral;behavioral phenotyping;Biological Assay;Biological Models;Categories;Characteristics;Cognitive;Communication;Communication impairment;Complex;Coupling;Cues;Data;deprivation;disability;Disease;Electrophysiology (science);entorhinal cortex;experience;experimental study;free behavior;Future;Goals;Hippocampus;Human;Impairment;in vivo;Individual;innovation;insight;Knowledge;Lateral;Link;Location;Machine Learning;mature animal;Medial;Methods;microphone;mouse model;Mus;Nervous System;Nervous System Disorder;neural;neural circuit;neurobiological mechanism;Neurobiology;neuromechanism;Neurons;neurophysiology;Neurophysiology - biologic function;nonhuman primate;novel;novel therapeutic intervention;optogenetics;Parkinson Disease;Pattern;Pheromone;Play;Research;response;Rodent;Role;Schizophrenia;Sensory;Shapes;skills;social;Social Behavior;social communication;Social Interaction;Socialization;sound;source localization;Stimulus;System;Techniques;Testing;therapeutic target;Time;tool;Touch sensation;Translational Research;transmission process;vocalization;wireless

PROJECT_TITLE: Neural Encoding of Social Information


NIH_SPENDING_CATS: Genetics;Human Genome

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative Our proposal seeks to understand how two genetic elements, termed enhancers and promoters, interact to turn on genes. The findings will provide important information relevant to dysregulated gene expression that occurs in human developmental disorders and cancer.

PI_NAMEs: CAREY, MICHAEL F (contact)

PROGRAM_OFFICER_NAME: CHOW, CHI-WING

PROJECT_TERMS: Address;Area;Auxins;Binding;biological systems;CCCTC-binding factor;Cells;ChIP-seq;Chromatin;Chromatin Loop;chromatin modification;chromosome conformation capture;Clustered Regularly Interspaced Short Palindromic Repeats;cohesin;combinatorial;Communication;Complex;Curiosities;Data;Development;developmental disease;DNA Polymerase II;Down-Regulation;Enhancers;Environment;EP300 gene;estrogen-related receptor;Eukaryota;Experimental Models;gain of function;Gene Activation;Gene Expression;Gene Order;Genes;Genetic;genetic element;Genetic Transcription;genome-wide;Genomics;Goals;Hi-C;Human;Imaging Techniques;Individual;Kidnappings;Knowledge;loss of function;Malignant Neoplasms;mammalian genome;Measurable;Mediator;Methodology;microscopic imaging;Modeling;Mouse Embryonic Stem Cells;Nature;Neighborhoods;novel;Organization administrative structures;Process;Progress Reports;promoter;Promoter Regions;protein protein interaction;Proteins;Regulatory Element;Regulon;Resolution;Role;Site;Small Interfering RNA;SMARCA4 gene;System;TAF1 gene;TAF12 gene;Testing;transcription factor;transcriptome sequencing

PROJECT_TITLE: Interplay Between Chromatin and Co-Activator Complexes

STUDY_SECTION: MGB

STUDY_SECTION_NAME: Molecular Genetics B Study Section[MGB]


NIH_SPENDING_CATS: Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Embryonic - Human

PROJECT_TERMS: Adoption;Award;Bioinformatics;bioinformatics infrastructure;bioinformatics resource;Biology;Centers of Research Excellence;Chromium;cluster computing;computer infrastructure;Computer software;computing resources;Core Facility;Custom;Data;Development;DNA Resequencing;Doctor of Philosophy;Educational workshop;empowerment;Epigenetic Process;Experimental Designs;Faculty;Fee-for-Service Plans;Generations;Genetic;Genome;genome analysis;genome sciences;genome-wide;genomic data;Genomics;graduate student;High Performance Computing;high throughput analysis;Human;Human Genetics;Human Resources;Infrastructure;innovation;Institution;instrumentation;Laboratories;Memory;Methods;model organism;Modernization;Molecular Biology;nanopore;next generation sequencing;Nucleotides;pathogen;Performance;Pilot Projects;Population;Postdoctoral Fellow;Program Research Project Grants;programs;Research;Research Personnel;Research Project Grants;Resources;RNA analysis;Running;Scientist;sequencing platform;Services;single cell analysis;single molecule;Sister;South Carolina;Statistical Data Interpretation;statistics;student training;success;Supervision;Technology;Tissue-Specific Gene Expression;Training;transcriptome sequencing;Universities;Variant;Workload

PROJECT_TITLE: Research Core


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Cost Effectiveness Research;HIV/AIDS;Health Services;Infectious Diseases;Mental Health;Mental Illness;Prevention

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE Common mental disorders such as depression and anxiety are extremely prevalent among people living with HIV, interfere with lifelong adherence to treatment, and are associated with risky sexual behaviors. We hypothesize that screening and treatment of common mental health disorders is an important component of the HIV response in sub-Saharan Africa, especially in areas that are not on track to achieve HIV epidemic control. We will determine the best role for mental health care as part of the HIV response in highly endemic areas of sub-Saharan Africa, while also ensuring that the resources spent measuring the HIV prevention needs of specific locations are justified by the benefits of a customized HIV response.

PI_NAMEs: BERSHTEYN, ANNA  (contact)

PROGRAM_OFFICER_NAME: SENN, THERESA ELAINE

PROJECT_TERMS: Adherence;Africa South of the Sahara;AIDS prevention;Anxiety;Area;authority;Behavioral;Caring;Characteristics;Classification;Collaborations;common treatment;Communities;cost;cost effectiveness;Cost Effectiveness Analysis;Country;Data;demographics;Diagnosis;Ensure;Epidemic;epidemic response;Equilibrium;Feedback;Fractals;frontier;Geography;Goals;Growth;Health;Health Benefit;Health Personnel;high risk population;high risk sexual behavior;HIV;HIV risk;in silico;Incidence;Infection;information gathering;Investments;Kenya;Knowledge;Link;Location;Maps;mathematical model;Mathematics;Measurable;Measures;Mental Depression;Mental disorders;Mental Health Services;Methods;Modeling;Nature;Pattern;Persons;Phase;Policies;pre-exposure prophylaxis;Prevalence;Prevention;programs;Proliferating;Property;Recording of previous events;Research Personnel;Resources;response;Risk;Risk Behaviors;Role;Running;Sample Size;scale up;screening;Services;simulation;Spottings;Sustainable Development;Taxonomy;Testing;transactional sex;Translations;Typology;United Nations;Variant;Visit;Work;Zambia

PROJECT_TITLE: Can mental health services break the cycle perpetuating HIV hotspots in sub-Saharan Africa?

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


ORG_CITY: BURLINGTON

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE

ORG_STATE: VT

PHR: Project Narrative  This program will investigate the enzymatic mechanisms of heme oxygenase enzymes using both spectroscopic characterization and computational modelling. Human heme oxygenases are drug targets due to their association with antioxidant and cytoprotective functions, along with neonatal jaundice, and improved fundamental understanding of the enzymatic reaction mechanism will aid these drug design efforts. Heme oxygenases are also part of iron acquisition pathways of pathogenic organisms, and fundamental understanding of these enzymes will aid antibiotic development.

PI_NAMEs: LIPTAK, MATTHEW D (contact)

PROGRAM_OFFICER_NAME: ASLAN, KADIR

PROJECT_TERMS: Active Sites;analog;Antibiotics;Antioxidants;Biliverdine;Binding;Biochemical Reaction;Biochemistry;Biological;Biological Assay;biological systems;Carbon;Chemicals;Computer Models;Cytoprotection;Data;Development;Drug Design;Drug Targeting;Enzymes;Eukaryota;fascinate;Heme;heme a;Human;Hydrogen Bonding;improved;insight;Iron;Knowledge;Measures;Modeling;Multienzyme Complexes;Neonatal Jaundice;Optics;Organism;Oxygen;Oxygenases;Pathogenicity;Pathway interactions;programs;Prokaryotic Cells;Proteins;Reaction;Recycling;Research Project Summaries;Site;Structure;Techniques

PROJECT_TITLE: Heme Oxygenases: chemically complex enzymes found in diverse biological pathways

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-Q(55)R]


NIH_SPENDING_CATS: Adolescent Sexual Activity;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Contraception/Reproduction;Dissemination and Implementation Research;HIV/AIDS;Health Services;Infectious Diseases;Mental Health;Pediatric;Prevention;Teenage Pregnancy;Women's Health Research

PHR: NARRATIVE New and innovative strategies are urgently needed to increase the uptake of HIV prevention and sexual and reproductive health services among adolescent girls and young women (AGYW) in sub-Saharan Africa. In this study, we will rigorously evaluate an innovative intervention intended to create AGYW-friendly drug shops in Tanzania that includes the distribution of HIV self-test kits alongside contraception and linkages to care. The results from the study will provide guidance about whether community-based distribution of HIV testing at drug shops is an effective strategy for decreasing the incidence of HIV and unintended pregnancies among AGYW.

PI_NAMEs: LIU, JENNY XIN (contact)

PROGRAM_OFFICER_NAME: KAMATH, SUSANNAH M A

PROJECT_TERMS: Accreditation;Adopted;Adoption;Adult;Africa;Africa South of the Sahara;Age;age related;AIDS prevention;antenatal care;Area;Awareness;barrier to care;base;Behavior;behavior change;Birth;Businesses;California;care seeking;Caring;Catchment Area;Characteristics;Child;Client;Clinic;Cluster randomized trial;Collaborations;Communities;Community Developments;Community-Based Distributions;Contraceptive Agents;Contraceptive methods;Counseling;Data;design;Diagnostic Reagent Kits;Effectiveness;effectiveness evaluation;Effectiveness of Interventions;Elderly;empowerment;enhancing factor;Environment;Equity;Face;Failure;Female Adolescents;Focus Groups;Fostering;Friends;Gender;girls;Goals;Government;Health;Health behavior;Health care facility;health care service;Health Personnel;Health Services;Health system;Heterogeneity;HIV;HIV diagnosis;HIV Infections;HIV-infected adolescents;human centered design;Human immunodeficiency virus test;implementation fidelity;implementation science;implementation strategy;improved;Incidence;Individual;innovation;Intervention;intervention program;Interview;Link;Liquid substance;Long-Term Effects;Methods;Modeling;Motivation;Oral;Outcome;Pathway interactions;Perception;Personal Satisfaction;Pharmaceutical Preparations;Pharmacy facility;Pilot Projects;Population;Pregnancy;Pregnancy Tests;Prevention;prevention service;primary outcome;Private Sector;Privatization;Program Effectiveness;programs;Provider;Randomized;Records;recruit;Reporting;Reproductive Health Services;Research;Respondent;Risk;Role;Sales;Sampling;San Francisco;secondary outcome;self testing;Services;sexual and reproductive health;Side;Signal Transduction;social stigma;South Africa;standard of care;success;Surveys;Tanzania;Time;unintended pregnancy;Universities;uptake;Vendor;Visit;vulnerable adolescent;Women's Health;young woman;Youth

PROJECT_TITLE: AmbassADDOrs for Health: Supporting young women's health through girl-friendly drug vendors


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Kidney Disease;Nutrition;Prevention

ORG_NAME: BOSTON MEDICAL CENTER

PHR: Narrative The aggressive form of kidney disease seen in blacks has been related to genetic risk variants prevalent in sub-Saharan Africa thought to be triggered by other genes and environmental factors. This application investigates diet (dietary nutrients and dietary factors) as risk factors and triggers for kidney disease in Africans.

PI_NAMEs: ILORI, TITILAYO OMOLARA (contact)

PROGRAM_OFFICER_NAME: GREER, RAQUEL CHARLES

PROJECT_TERMS: Acceleration;Address;Africa;Africa South of the Sahara;African;African American population;American;Anti-Inflammatory Agents;Apolipoproteins;biobank;Biological Markers;Biometry;Black Populations;blood pressure elevation;Boston;career;Career Choice;Cessation of life;Chronic Kidney Failure;Collection;cost;Data Analyses;design;Development;Diabetes Mellitus;Dialysis procedure;Diet;dietary;Dietary Factors;Dietary Fiber;Dietary intake;Dietary Potassium;Dietary Practices;Dietary Sodium;Disease;disease phenotype;Disease Progression;disorder risk;early onset;Elements;End stage renal failure;Environmental Exposure;Environmental Risk Factor;Europe;Excretory function;Fruit;Funding;gene environment interaction;Gene Expression;gene interaction;Genes;Genetic;genetic epidemiology;Genetic Risk;genetic risk factor;Genomics;Genotype;global health;Health;health determinants;health disparity;High Prevalence;high risk;Human;Incidence;Individual;Inflammasome;Inflammation;Inflammatory;Inherited;Injury to Kidney;Intake;Intervention Studies;K-Series Research Career Programs;Kidney;Kidney Diseases;Kidney Transplantation;Life;Life Style;Link;Maintenance;Malignant - descriptor;Measures;medical schools;Minority;mitochondrial dysfunction;modifiable risk;Modification;National Institute of Diabetes and Digestive and Kidney Diseases;nephrotoxicity;new therapeutic target;novel;Nutrient;nutrition;nutritional epidemiology;Outcome;Oxalates;Parents;Participant;patient oriented research;Patients;Phenotype;Population;Potassium;professor;prospective;Prospective Studies;Prospective, cohort study;Public Health;public health research;Renal function;Research;Research Project Grants;Resources;Risk;Risk Factors;Risk Reduction;risk variant;Role;skill acquisition;skills;Sodium;Testing;Toxic effect;Training;Transplantation;Universities;urinary;Urine;Variant;Vegetables

PROJECT_TITLE: The Role of Dietary Nutrients in Chronic Kidney Disease Progression and Apolipoprotein L1 Nephropathy

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Emerging Infectious Diseases;Genetics;Human Genome;Infectious Diseases

PI_NAMEs: ALEXANDROV, ANDREI  (contact)

PROJECT_TERMS: anti-cancer;Anti-viral Therapy;Biochemical;Biogenesis;cancer therapy;Candidate Disease Gene;Cell Line;Cells;Centers of Research Excellence;Color;Complex;Cytoplasm;design;developmental disease;Disease;Down-Regulation;embryonic stem cell;Endocrine;Fluorescence;forward genetics;Foundations;gammaherpesvirus;gene discovery;gene network;Genes;Genetic;genetic analysis;genome-wide;genome-wide analysis;Goals;high throughput screening;Human;human disease;human embryonic stem cell;Human Genetics;Human Herpesvirus 8;Immune;in vivo;Individual;Investigation;knowledge of results;Libraries;Lytic;MALAT1 gene;Malignant Neoplasms;men;MEN1 gene;Methods;Molecular;Neoplasms;Neuronal Differentiation;Nuclear;Nuclear Export;particle;Pathogenicity;Pathway interactions;Poly A;Poly(A)+ RNA;Post-Transcriptional Regulation;Production;Refractory;Regulation;Reporter;RNA;Role;screening;stem cell differentiation;Technology;Therapeutic;Therapeutic Intervention;therapeutic target;Transcript;triple helix;Untranslated RNA;Viral;Virus Diseases

PROJECT_TITLE: Forward Genetic Analysis of Human Nuclear Long Non-Coding RNAs


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Infant Mortality;Lung;Neonatal Respiratory Distress;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Precision Medicine;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases

ORG_DEPT: PEDIATRICS

PHR: PROJECT NARRATIVE Bronchopulmonary dysplasia (BPD) in preterm infants is a common and often severe lung disease with long term sequelae. Currently, there are no biological markers available to predict which infants will develop BPD or to assess options for prevention and treatment. The goal of this project is to characterize infant physiology using metabolomics, and to investigate the role of race/ethnicity, genetics and medical interventions in order to increase our knowledge of the biological basis of BPD and improve the health and outcome of these infants.

PI_NAMEs: BALLARD, PHILIP L. (contact);TORGERSON, DARA

PROGRAM_OFFICER_NAME: SOOD, BEENA G

PROJECT_TERMS: Acute;Adrenal Cortex Hormones;African American;Age;aspirate;Biochemical;Biochemical Pathway;Biological;Biological Markers;biomarker development;Black American;Bronchopulmonary Dysplasia;Cessation of life;Childhood;clinical biomarkers;cohort;Cohort Studies;Development;Diagnosis;Disease;disorder risk;early detection biomarkers;Early Diagnosis;Early identification;Early treatment;empowerment;Environment;Environmental Exposure;ethnic difference;Ethnic Origin;Ethnic Population;Extremely low gestational age newborn;Genetic;Genetic Processes;Genetic study;genome wide association study;genomic locus;Genomics;Gestational Age;Goals;Growth;Health;high risk;high risk population;improved;Infant;infant outcome;inhaled nitric oxide;insight;Intervention;Knowledge;knowledge base;Liquid substance;long-term sequelae;Lung;lung development;lung developmental disorder;Lung Diseases;Measures;Medical;metabolic profile;metabolome;metabolomics;Molecular;Mothers;multiple omics;novel;novel marker;nutrition;Outcome;Pathogenesis;Pathway interactions;Patient Self-Report;Pharmaceutical Preparations;Physiological Processes;Physiology;Population;Population Heterogeneity;postnatal;Postnatal respiratory distress;Pregnancy;premature;Premature Infant;prevent;Prevention;Process;programs;Quantitative Trait Loci;Race;racial difference;racial diversity;racial population;Resources;respiratory;respiratory morbidity;response;Risk Assessment;Role;Severities;social;Sum;supplemental oxygen;surfactant;targeted treatment;Testing;Therapeutic;Time;time use;Trachea;urinary;Urine;Variant

PROJECT_TITLE: Integrative metabolomics of bronchopulmonary dysplasia in extremely low gestational age infants

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Hepatitis;Liver Disease

ORG_CITY: RICHMOND

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: Non-alcoholic fatty liver disease (NAFLD) affects 1 in 4 adults, has no FDA-approved treatments, and increases the risk of developing end-stage liver disease and several cancers. Our proposed study examines the potential role of sphingosine kinase 2 (SphK2) in preventing hepatocyte mitochondrial dysfunction and inflammation, which coincide with NAFLD progression. These findings will significantly enhance our knowledge of fundamental hepatocyte biology and may inspire future research investigating sphingolipids as a potential drug target for NAFLD treatment.

PI_NAMEs: JACKSON, KAITLYN GEORGENE (contact)

PROGRAM_OFFICER_NAME: DENSMORE, CHRISTINE L

PROJECT_TERMS: Adenovirus Vector;Adult;Affect;Anti-Inflammatory Agents;Bile Acids;Biochemical;Biological;Biology;Cardiac Myocytes;Cell Nucleus;Cell Physiology;Cells;Clinical;Complex;complex IV;cytochrome c;cytochrome c oxidase;cytokine;Data;Disease;Disease Progression;Drug Targeting;end stage liver disease;endoplasmic reticulum stress;Evaluation;Exhibits;Exposure to;fatty acid oxidation;Fatty Liver;FDA approved;Flow Cytometry;Future;Genes;Genetic Transcription;Goals;Hepatic;Hepatocyte;hepatocyte injury;Histone Deacetylase Inhibitor;Human;Immune;immune cell infiltrate;Immune response;immunoregulation;improved;In Vitro;in vivo;Incidence;Inflammation;Inflammatory;Inflammatory Response;Innate Immune Response;innovation;Intervention;Knockout Mice;Knowledge;Kupffer Cells;Link;lipid metabolism;Lipids;Literature;Liver;liver inflammation;Location;Malignant Neoplasms;Measures;Mediator;Membrane Potentials;Metabolic Diseases;Metabolic stress;Metabolism;Mitochondria;mitochondrial dysfunction;mitochondrial membrane;Modeling;Molecular;mouse model;new therapeutic target;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;novel;novel therapeutic intervention;Nuclear;Ontology;overexpression;Oxidative Stress;Palmitic Acids;Pathogenesis;Patients;Pattern;Peripheral;pharmacologic;Pharmacotherapy;Population;Prevalence;prevent;prohibitin;protective effect;Protein Isoforms;Reactive Oxygen Species;Regulation;Reporting;response;Risk;Role;Saturated Fatty Acids;Signal Transduction;Signaling Molecule;Source;Sphingolipids;sphingosine 1-phosphate;sphingosine kinase;Sphingosine-1-Phosphate Receptor;System;Testing;trafficking;transcriptome sequencing;Up-Regulation;Variant;western diet;Wild Type Mouse

PROJECT_TITLE: The role of sphingosine kinase 2 in mitochondrial dysfunction and NAFLD


PHR: Project Narrative Community college (CC) students suffer high rates of depression and anxiety in the face of daunting life challenges (e.g. housing and food insecurity) without adequate mental health resources. This Center aims to optimize the effectiveness and implementation of a system for screening, tracking and treating anxiety and depression in a low-income, diverse community college student population, and explore pathways for sustainability and spread to other community colleges.

PI_NAMEs: CRASKE, MICHELLE G (contact);WOLITZKY-TAYLOR, KATE BASIA

PROGRAM_OFFICER_NAME: ROONEY, MARY

PROJECT_TERMS: Acceleration;Address;Adherence;Administrator;Advocacy;Affect;Algorithms;Anxiety;anxiety treatment;Area;Awareness;behavior influence;Behavioral;Budgets;California;care systems;Caring;Chronic;Clinical;Clinical Sciences;Cognitive;Cognitive Therapy;cohort;Collaborations;college;Communities;community barrier;community college;cost effectiveness;County;cultural competence;Data;Data Science;data streams;Decision Making;design;Detection;digital mental health;disparity gap;early life adversity;Economics;Education;Effectiveness;ethnic minority;Ethnic Origin;Evaluation;evidence base;falls;Financial Hardship;food insecurity;Funding;Geography;Goals;Health Care Costs;health disparity;health literacy;Health Resources;health service use;Health Status;Healthcare Systems;Hearing;higher education;Homelessness;Housing;implementation barriers;implementation efforts;implementation facilitators;implementation framework;implementation science;improved;innovation;Investigation;Investments;Learning;Life;Life Stress;Los Angeles;Low income;Mental Depression;Mental Health;Mental Health Services;Methods;Mind;minority student;model generalizability;Modeling;operation;Outcome;Pathway interactions;peer coaching;Performance;Persons;Pilot Projects;pilot trial;Policy Maker;Population;prediction algorithm;predictive modeling;Prevention;programs;Provider;Public Health;Quality of Care;Race;racial minority;rapid detection;recruit;reduce symptoms;Research Personnel;Research Project Grants;Research Support;Resources;Risk;Risk Reduction;Sampling;satisfaction;Science;screening;Self Efficacy;Self-Injurious Behavior;Services;Severities;social determinants;social stigma;socioeconomics;Source;Students;substance use;success;suicidal;Suicide;Suicide prevention;Supervision;Surveys;Symptoms;System;Testing;tool;Training;treatment response;Triage;Unemployment;university student;Update;uptake;user centered design

PROJECT_TITLE: Screening, Tracking and Treatment for Anxiety and Depression in Community Colleges


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Infectious Diseases;Social Determinants of Health

ORG_CITY: LARAMIE

ORG_NAME: UNIVERSITY OF WYOMING

ORG_STATE: WY

PHR: Narrative Self-nonself recognition is an essential function that maintains and protects cooperative interactions among cells in a multicellular organism. As an example, our immune system interacts harmoniously with our own tissues, while eliminating foreign pathogens and non-cooperative cancer cells. This proposal investigates a new paradigm for cellular self-recognition and how cells assemble cooperative multicellular behaviors

PI_NAMEs: WALL, DANIEL  (contact)

PROGRAM_OFFICER_NAME: BLATCH, SYDELLA ANNE

PROJECT_TERMS: Address;antagonist;Area;Bacteria;Behavior;Biology;Biosensor;cancer cell;cell assembly;cell behavior;Cell Communication;cell injury;Cell Surface Receptors;Cells;cellular development;Cellular Structures;Cellularity;Complex;Discrimination;Environment;environmental stressor;Exhibits;Future;Genes;Goals;Horizontal Gene Transfer;Immune system;Immunity;Individual;Investigation;Life;Lipids;Mediating;Membrane;Membrane Fusion;model organism;Monitor;Motility;Movement;Myxococcales;Myxococcus xanthus;Nonlytic;Organ;Organism;particle;pathogen;Population;Process;Property;Proteins;receptor;release of sequestered calcium ion into cytoplasm;repaired;Research;response;Role;Signal Transduction Pathway;Social Discrimination;social group;Social outcome;Starvation;Tissues;Toxin;trait;transcriptome

PROJECT_TITLE: Self-nonself recognition and multicellularity in myxobacteria

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-S(55)R]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Genetics;Human Genome;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Embryonic - Human

PI_NAMEs: FLANAGAN STEET, HEATHER R (contact)

PROJECT_TERMS: Address;Affect;Biochemical;Bioinformatics;Biosensor;Cartilage;cartilage development;Cell Adhesion Molecules;Centers of Research Excellence;Chondrocytes;Chondrogenesis;clinical phenotype;confocal imaging;Congenital disorders of glycosylation;Defect;Development;Disease;Drosophila genus;Embryo;Environmental Risk Factor;Enzymes;Exhibits;Fishes;fly;Foundations;Future;Gene Expression;Genes;Genetic;genetic manipulation;glycosylation;Goals;Guanosine Diphosphate Mannose;Heat-Shock Response;Hereditary Disease;Human Genetics;Impairment;in vivo;Individual;Knowledge;Laboratories;Link;mannose 1-phosphate;mannose 6 phosphate;Maps;Matrix Metalloproteinases;Mendelian disorder;Methods;Modeling;Molecular;Molecular Genetics;mutant;Mutation;N-Cadherin;novel;null mutation;Pathogenesis;Pathogenicity;Pathology;Pathway interactions;Patients;Penetrance;Peptide Hydrolases;pharmacologic;Phenotype;Phosphomannomutase;Polysaccharides;Process;Production;promoter;Protein Glycosylation;Proteins;Research Project Grants;Services;Severity of illness;Signal Transduction;Single-Gene Defect;stem;sugar nucleotide;System;Technology;Testing;Tissues;tool;transcriptome sequencing;Transgenic Organisms;Viral;Work;Zebrafish

PROJECT_TITLE: Research Project 2


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Health Services;Mental Health;Mental Illness

PI_NAMEs: CRASKE, MICHELLE G (contact)

PROJECT_TERMS: Administrator;Advocate;Anxiety;anxiety reduction;anxiety treatment;Award;California;care systems;career;Clinical;Clinical Research;Clinical Services;Collaborations;Communication;Communities;community college;Consult;Data;Decision Making;Effectiveness;Ensure;Environment;Ethics;ethnic diversity;Evaluation;experience;Faculty;Feedback;Funding;Future;Goals;Grant;Health Resources;healthcare community;Human Resources;human subject protection;Human Subject Research;implementation barriers;Improve Access;improved;Infrastructure;innovation;Intervention;Leadership;Life;Manuscripts;Marketing;meetings;Mental Depression;Mental Health;Mental Health Services;Mentors;Mentorship;Methods;Mission;multidisciplinary;next generation;operation;Pilot Projects;Preparation;programs;Provider;Publications;racial diversity;Research;research data dissemination;Research Ethics;Research Infrastructure;Research Personnel;Research Project Grants;Research Support;Research Training;Resources;Rice;Risk;Role;Scientist;screening;Self-Injurious Behavior;Services;social media;Solid;Structure;Students;Suicide;symposium;timeline;Training;university student;Vision;web platform;web site;Work

PROJECT_TITLE: Admin Core


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Data Science;Depression;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Mental Illness;Social Determinants of Health

PI_NAMEs: MIRANDA, JEANNE  (contact)

PROJECT_TERMS: Acceleration;Address;Adoption;Algorithms;Anxiety;anxiety treatment;Area;California;care systems;Caring;Clinical;clinical decision-making;Clinical Sciences;college;Communities;community based participatory approach;community college;community engagement;Complex;Consultations;cultural competence;Cultural Diversity;Data;Data Collection;data hub;data infrastructure;data management;data modeling;Data Science;Decision Making;decision making algorithm;design;Detection;digital mental health;effective therapy;Effectiveness;Ensure;Ethnic Origin;Evaluation;Faculty;Funding;Goals;Grant;health disparity;Health Sciences;high risk population;implementation framework;implementation science;improved;Infrastructure;innovation;interdisciplinary collaboration;Interdisciplinary Study;Knowledge;Los Angeles;Low income;member;Mental Depression;Mental Health;Mental Health Services;Mentors;Methodology;Methods;Modeling;Monitor;multidisciplinary;Pilot Projects;Population;predictive modeling;Procedures;programs;Protocols documentation;Public Health;Race;Randomized, Controlled Trials;recruit;Research;Research Personnel;Research Project Grants;research study;Research Support;Resources;Risk;Sampling;screening;social determinants;Statistical Models;student participation;Student recruitment;Students;Supervision;synergism;System;Technology;Time;Training;Triage;university student;uptake;Work;working group

PROJECT_TITLE: Methods Core


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Biotechnology;Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Genetics;Human Genome;Neurosciences;Pediatric

ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: PROJECT NARRATIVE A major challenge in treating birth defects and developing regenerative medicine is to better understand complex systems of cell fate specification in stochastic and dynamic environments. This application will exploit novel experimental tools and new computational methods to uncover new mechanisms that control fate specification in neural crest cells that form diverse tissues including body pigmentation, the peripheral nervous system and the skull. The expected new results are directly relevant to treating birth defects, regenerative therapy, and therapeutic strategies for the many diseases associated with these derivatives of the neural crest.

PI_NAMEs: NIE, QING ;SCHILLING, THOMAS F (contact)

PROGRAM_OFFICER_NAME: SAIFUDEEN, ZUBAIDA

PROJECT_TERMS: Actins;Adhesions;Adhesives;Behavior;Biography;Cadherins;Cell Adhesion;Cell Communication;Cell Differentiation process;cell fate specification;Cell Lineage;cell motility;Cell Physiology;cell type;Cell-Cell Adhesion;Cells;Cephalic;Complex;Computer Models;Computing Methodologies;Congenital Abnormality;craniofacial;cranium;Cytoskeleton;Data;Data Set;Defect;Development;Disease;Dorsal;Embryo;Embryonic Development;Emigrations;Environment;Epithelium;Event;First Pharyngeal Arch;Focal Adhesions;Gene Combinations;Gene Expression;Gene Expression Profiling;gene function;gene regulatory network;Genes;Genetic Models;Heterogeneity;Image;imaging platform;in vivo;in vivo imaging;Individual;insight;intercellular communication;interdisciplinary approach;Label;live cell imaging;Location;Malignant Neoplasms;Mandible;Maps;Melanoma;Mesenchymal;Methods;migration;Monitor;Movement;mutant;Mutation;Neural Crest;Neural Crest Cell;novel;novel strategies;Organ;Pattern;Peripheral Nervous System;Pigmentation physiologic function;Pigments;population migration;Process;programs;Proteins;Publishing;Regenerative Medicine;regenerative therapy;Regulation;Reporter;Research;response;Role;single-cell RNA sequencing;skeletal;Skeleton;Sorting;spatiotemporal;Specific qualifier value;System;Testing;Therapeutic;Time;Tissues;tool;trafficking;transcriptome sequencing;WNT Signaling Pathway;Zebrafish

PROJECT_TITLE: Dissecting single cell dynamics that coordinate neural crest migration and diversification

STUDY_SECTION: SBDD

STUDY_SECTION_NAME: Skeletal Biology Development and Disease Study Section[SBDD]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Homelessness;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Racial and Ethnic Minority Health Research;Social Determinants of Health

PROJECT_TERMS: Acculturation;active method;Acute;adaptation algorithm;Address;Adherence;algorithm development;Algorithms;Anxiety;anxiety symptoms;anxiety treatment;automated algorithm;Back;California;care systems;Caring;Characteristics;clinical decision-making;Cognitive Therapy;college;community college;comorbidity;cost effectiveness;Critical Pathways;cultural competence;Data;Decision Making;decision making algorithm;depressive symptoms;design;disability;Discrimination;early life adversity;Effectiveness;emotion dysregulation;Employment;Enrollment;ethnic minority;Ethnic Origin;Family;food insecurity;food security;functional outcomes;Gender;Generations;Geography;Goals;health determinants;health disparity;health service use;Health Status;Home;Homelessness;Housing;Immigration;Impairment;implementation framework;improved;Income;Individual;Investments;Lead;Life;Life Stress;Los Angeles;Low income;Managed Care;Measures;Mental Depression;Mental Health;Mental Health Services;Methods;Mind;minority student;Monitor;Neurocognitive;Observational Study;Occupational;Outcome;personalized care;Population;prediction algorithm;preference;Prevention;programs;Race;racial minority;Randomized;Recording of previous events;response;Sampling;Science;screening;Severities;Sex Orientation;social;social determinants;Social support;sociodemographics;socioeconomics;standard of care;Statistical Models;stressor;Suicide;Surveys;symptomatic improvement;Symptoms;Testing;theories;Time;Time Study;tool;treatment adherence;Treatment outcome;Triage;underserved community;university student;Workforce Development

PROJECT_TITLE: Signature Project


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Uterine Cancer;Women's Health Research

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: PROJECT NARRATIVE Endometrial cancer is becoming increasingly common, particularly in women with aggressive tumors who have poor outcomes. African American women have higher mortality than other racial/ethnic groups even after accounting for stage, histology, comorbid conditions, and treatment. Here, we will use the largest, most diverse population to date (including >1,000 African American and >2,000 non-African American endometrial cancer patients) to investigate endometrial tumor genomics, distinct risk factor profiles across tumor types, and the role of underlying tumor biology in driving this large survival disparity.

PI_NAMEs: DE VIVO, IMMACULATA  (contact);DU, MENGMENG ;SETIAWAN, VERONICA WENDY

PROGRAM_OFFICER_NAME: MECHANIC, LEAH E

PROJECT_TERMS: Accounting;African American;African American population;African American Women;Algorithms;anti-cancer research;Automobile Driving;Bioinformatics;Biology;Blood;cancer genome;cancer health disparity;Cancer Patient;cancer subtypes;carcinogenicity;Carcinoma;Cessation of life;Classification;Clear Cell;Clinical;Collaborations;comorbidity;cost;Data;Development;Diagnosis;Diagnostic;disorder prevention;Disparity;Endometrial Carcinoma;Endometrial Neoplasms;Endometrioid Tumor;Epidemiology;epidemiology study;Ethnic Population;Etiology;exome;exome sequencing;experience;Foundations;Frequencies;Funding;Future;Genetic;genetic risk factor;genomic profiling;genomic variation;Genomics;Genotype;Germ Lines;Hereditary Disease;Heterogeneity;high risk;Histology;improved;Incidence;Informatics;insertion/deletion mutation;insight;Intervention;Knowledge;Letters;Life Style;Malignant Female Reproductive System Neoplasm;Malignant Neoplasms;Maps;Mediation;Molecular;Molecular Profiling;molecular subtypes;mortality;mortality disparity;Mutation;novel;Oncogenes;Outcome;Patient Selection;Patients;Point Mutation;Population;population based;Population Heterogeneity;predictive tools;Prevention strategy;Process;Prognosis;prognostic significance;racial difference;racial disparity;racial diversity;racial population;reproductive;Research;Resources;Risk;Risk Factors;risk prediction;Role;sample collection;Sampling;Sequence Analysis;Serous;sociodemographics;Somatic Mutation;Statistical Data Interpretation;survival disparity;Techniques;Testing;The Cancer Genome Atlas;tumor;Tumor Biology;Tumor stage;Tumor Subtype;Variant;White Women;Woman

PROJECT_TITLE: Comprehensive molecular characterization of endometrial cancer, etiologic heterogeneity, and racial disparities

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-C(02)M]


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Hepatitis;Liver Disease;Nutrition

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project narrative Disease pathogenesis for non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) remains poorly understood and attempts to modulate a singular hepatic lipid homeostatic pathway have been plagued by unexpected compensation and feedback loops. We have shown that loss of hepatic folliculin (FLCN) robustly protects against NAFLD/NASH via an FLCN-mTORC1-TFE3 signaling axis that controls de novo lipogenesis and fatty acid oxidation. We have evidence that this non-canonical mTORC1 signaling also regulates VLDL-TG secretion and we propose that upregulated VLDL-TG secretion is a major mechanism by which loss of FLCN protects against NAFLD/NASH.

PI_NAMEs: THORSHEIM, CHELSEA  (contact)

PROJECT_TERMS: Affect;American;Biological Assay;Blood Circulation;career;Cirrhosis;Compensation;Data;defined contribution;detection of nutrient;Development;Diet;Disease;Enzymes;Fatty acid glycerol esters;fatty acid oxidation;FDA approved;Feedback;feeding;Fibrosis;Folliculin;FRAP1 gene;Genes;Genetic Transcription;genetic variant;Hepatic;Histology;Human;human disease;Human Genetics;Immunohistochemistry;improved;Infection;Inflammation;insight;Intervention;Investigation;Knock-out;Knockout Mice;Lead;Lecithin;Left;lipid biosynthesis;Lipids;Liver;liver metabolism;Measures;Mediating;Messenger RNA;Metabolic;mouse model;Mus;non-alcoholic fatty liver;non-alcoholic fatty liver disease;Non-Insulin-Dependent Diabetes Mellitus;nonalcoholic steatohepatitis;Nuclear;Obesity;Organ;overexpression;particle;Pathogenesis;Pathway interactions;Patients;Peripheral;Persons;Pharmacotherapy;Phosphorylcholine;Predisposition;prevent;Primary carcinoma of the liver cells;Process;Proteins;Public Health;Regulation;Research;Risk;Risk Factors;Role;Signal Transduction;Steatohepatitis;Testing;Therapeutic;therapeutic target;Tissues;transcription factor;Transcriptional Activation;Triglycerides;Up-Regulation;uptake;Very low density lipoprotein;very low density lipoprotein triglyceride;Wild Type Mouse;Work

PROJECT_TITLE: Investigating folliculin as a regulator of VLDL-TG secretion in non-alcoholic fatty liver disease and steatohepatitis


PI_NAMEs: KONKEL, MIRIAM KRISTINE (contact)

PROJECT_TERMS: Algorithms;Alu Elements;Back;Binding Sites;Biology;Birth;burden of illness;candidate identification;Centers of Research Excellence;Code;Codon Nucleotides;comparative;comparative genomics;Complex;contig;Custom;Data;Data Set;Diagnostic;Disease;DNA Insertion Elements;DNA Polymerase II;DNA Polymerase III;DNA Sequence;DNA Transposable Elements;Elements;Embryo;Enhancers;Evolution;Exons;Family;Foundations;Future;Gene Expression Regulation;gene regulatory network;Genes;Genetic;Genetic Diseases;Genetic Recombination;Genetic Transcription;Genetic Variation;Genome;genome annotation;genome sequencing;Genomic approach;Genomic Segment;Genomics;Germ Lines;Human;human data;human disease;Human Genetics;Human Genome;human reference genome;improved;Individual;Inherited;insertion/deletion mutation;Investigation;Jumping Genes;Knowledge;Life;life span;Literature;Live Birth;Location;mammalian genome;Messenger RNA;Mutation;Nature;offspring;Output;Pan Genus;personalized approach;Phase;Play;Polymerase;Population;Predisposition;premature;Primates;prospective;Proteins;Recording of previous events;reference genome;Regulation;Repetitive Sequence;Research Project Grants;Resolution;Retrotransposition;RNA;RNA Splicing;Role;Site;Source;Structure;success;targeted sequencing;Tissues;transcription factor;Untranslated RNA;Variant;whole genome

PROJECT_TITLE: Research Project 3


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Mental Illness;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: CHAVIRA, DENISE A (contact)

PROJECT_TERMS: academic standard;active control group;Address;Advertisements;Affect;Anxiety;anxiety treatment;Attitude;Attitude to Health;Awareness;Collaborations;college;Communities;community college;Community Developments;community engaged intervention;community engagement;Consent;cost;Data;digital;Discrimination;Disparity;Economics;Educational Materials;Effectiveness;effectiveness evaluation;effectiveness testing;Electronic Mail;Eligibility Determination;Enrollment;ethnic minority;experience;Focus Groups;Future;Goals;health disparity;health knowledge;Health Services Accessibility;improved;inhibitor;Intervention;Latinx;Literature;Lived experience;Location;Logistics;Los Angeles;Low income;Mental Depression;Mental disorders;Mental Health;Mental Health Services;minority student;motivational enhancement therapy;Participant;peer;peer coaching;Perception;Phase;primary outcome;programs;racial minority;Randomized;recruit;screening;secondary outcome;Self Efficacy;service uptake;service utilization;Services;social;social contact;social culture;social stigma;stressor;Structure;Students;System;Telephone;Testing;Time;Trust;Universities;university student;uptake;user centered design;Visit;willingness

PROJECT_TITLE: Project 1