ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Clinical Research;Dissemination and Implementation Research;Emergency Care;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Homelessness;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE Acute alcohol intoxication is prevalent in patients cared for by the emergency medical system and emergency departments, impacting individual and community health and health system resource utilization. Improved understanding of incidence of uncomplicated alcohol intoxication and the decision-making of ambulance personnel in triage of these patients will contribute to the appropriate use of resources for acute uncomplicated alcohol intoxication, including the Sobering Center and ED.

PI_NAMEs: SMITH-BERNARDIN, SHANNON  (contact)

PROGRAM_OFFICER_NAME: WHITAKER, DAMIYA EVE

PROJECT_TERMS: Accident and Emergency department;Acute;acute care;addiction;Address;Adult;Affect;Alcohol consumption;alcohol use disorder;Alcohol withdrawal syndrome;Alcoholic Intoxication;Ambulances;Assessment tool;Cardiac;Caring;Characteristics;chronic alcohol ingestion;Classification;Clinical;Communities;Community Health;Complication;cost effective;Crowding;Data;Decision Making;design;Deterioration;Development;Diagnosis;dissemination science;Doctor of Philosophy;Effectiveness of Interventions;Emergency Care;Emergency department visit;Emergency Medicine;Environmental Risk Factor;Evaluation;Event;Evidence based intervention;Evidence based treatment;experience;Foundations;Funding;Future;Goals;Grant;Harm Reduction;Health;Health Policy;Health Services Research;Health system;Healthcare;Homeless persons;Homelessness;hospital patient care;Hospitals;Hour;Human Resources;hybrid type 2 trial;implementation science;improved;Incidence;Individual;Injury;innovation;Interview;Intoxication;Intracranial Hemorrhages;Intubation;Leadership;Liver Failure;Maps;Medical;Medical emergency;Mentored Research Scientist Development Award;Mentorship;Methods;Monitor;Morbidity - disease rate;mortality;multidisciplinary;novel;Nurses;Paramedical Personnel;Patient Care;Patient Triage;Patients;Persons;Play;Policies;prevent;programs;Provider;provider factors;psychiatric emergency;Publications;Qualitative Research;Recording of previous events;recruit;Research;Research Methodology;Research Personnel;Resources;Safety;Sampling;San Francisco;Scientist;Services;skills;sobriety;Solid;Statistical Methods;statistics;System;Testing;Training;Training Programs;Transportation;Triage;United States;Variant;Ventilatory Depression;Visit;Vulnerable Populations;Writing

PROJECT_TITLE: Evaluation of paramedic decision making in triage and transport of adults with acute uncomplicated alcohol intoxication to the emergency department versus sobering center


ADMINISTERING_IC: DK

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Diabetes;Immunotherapy;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_COUNTRY: UNITED STATES

ORG_DEPT: SURGERY

ORG_FIPS: US

PHR: NARRATIVE This collaborative research program will advance immunotherapies for type 1 diabetes by developing cell engineering strategies to target regulatory T cells to the pancreatic islets and creating a platform for monitoring their activation in the target tissue.

PI_NAMEs: MCMANUS, MICHAEL T;PARENT, AUDREY ;TANG, QIZHI  (contact)

PROGRAM_OFFICER_NAME: GUPTA, DHANANJAY

PROJECT_TERMS: Address;Aggressive behavior;Antigen Presentation;Antigens;Autoimmune;Autoimmune Diabetes;Bar Codes;Beta Cell;Biological Markers;Blood;Cell Therapy;Cells;Cellular biology;cellular engineering;Clinical;Development;Diabetes Mellitus;differentiation in vitro;early phase clinical trial;Effectiveness;efficacy evaluation;endocrine pancreas development;Engineering;experience;extracellular vesicles;Frequencies;HLA-A2 Antigen;Homeostasis;Human;human pluripotent stem cell;humanized mouse;Immune;immune self tolerance;Immunology;Immunosuppression;Immunotherapy;improved;In Vitro;in vivo;Individual;Inflammation;Infusion procedures;Insulin-Dependent Diabetes Mellitus;islet;Islets of Langerhans;Knowledge;lymph nodes;Maps;Mass Spectrum Analysis;Molecular;Monitor;mouse model;next generation;Pancreas;Patients;Peptides;peripheral blood;preproinsulin;preservation;prevent;Process;Program Description;programs;Regulatory T-Lymphocyte;Research;Research Personnel;RNA;Safety;selective expression;Specificity;stem cells;Structure of beta Cell of islet;Surface;synergism;T cell therapy;T-Cell Immunologic Specificity;T-Lymphocyte Subsets;TCR Activation;Technology;technology development;Testing;therapeutic target;therapy development;Tissues

PROJECT_TITLE: iSTAR Tregs


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Breast Cancer;Cancer;Clinical Research;Colorectal Cancer;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Opioids;Prevention;Prostate Cancer;Rural Health;Social Determinants of Health;Urologic Diseases;Women's Health Research

ORG_CITY: SALT LAKE CITY

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: NARRATIVE There are an estimated 2.8 million rural cancer survivors today, and they experience lower survival rates than cancer patients living in urban areas. We propose to conduct a study of rural prostate, rural breast, rural colorectal cancer patients and comparison groups of urban cancer patients in Utah and in elderly patients across the US, to investigate whether rural cancer survivors experience higher rates of adverse outcomes such as cardiovascular disease, diabetes, opioid use disorders and mental illness than urban cancer survivors. We will also assess why rural cancer survivors may experience higher adverse outcome rates, with possible reasons including differences in the cancer treatment they receive or the distance to care.

PI_NAMEs: CAMP, NICOLA J. (contact);HASHIBE, MIA

PROGRAM_OFFICER_NAME: GALLICCHIO, LISA M

PROJECT_TERMS: Address;adverse outcome;Body mass index;Body System;Breast;Breast Cancer Patient;cancer diagnosis;Cancer Etiology;cancer health disparity;Cancer Patient;cancer survival;Cancer Survivor;Cancer Survivorship;cancer therapy;Cardiotoxicity;Cardiovascular Diseases;Caring;Chronic Disease;cohort;colon cancer patients;Colorectal Cancer;comorbidity;comparison group;Computerized Medical Record;Data;Databases;design;Development;Diabetes Mellitus;diabetes risk;Diagnosis;Disease;disorder prevention;disorder risk;Elderly;Endometrial Carcinoma;experience;Family;Family history of;follow-up;Future;Health care facility;Health Insurance;Health Services Accessibility;high risk;human old age (65+);improved;Incidence;innovation;Insurance Coverage;Intervention;Late Effects;Link;Longterm Follow-up;Malignant Breast Neoplasm;Malignant neoplasm of prostate;Malignant neoplasm of testis;Malignant neoplasm of thyroid;Malignant Neoplasms;Medicare;Mental Depression;Mental disorders;Mental Health;Monitor;neoplasm registry;Obesity;older patient;Older Population;Operative Surgical Procedures;opioid use;opioid use disorder;Outcome;Population;population based;Population Database;preventive intervention;Primary Care;Prostate;Publishing;Radiation;Recording of previous events;Records;Registries;Research;Risk;Risk Assessment;risk prediction model;Rural;rural dwellers;Rural Population;Sample Size;Screening for cancer;Smoking;Survival Rate;Telemedicine;Time;Tobacco smoking behavior;Tobacco Use Cessation;urban area;Urban Population;Utah

PROJECT_TITLE: Long-Term Adverse Outcomes Among Rural Cancer Survivors in a Population-Based Cohort

STUDY_SECTION: CHSA

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology A Study Section[CHSA]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Data Science;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Ovarian Cancer;Prevention;Rare Diseases;Women's Health Research

ORG_CITY: LOS ANGELES

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

PHR: PROJECT NARRATIVE Ovarian cancer is responsible for more than 150,000 deaths per year and so it remains a high priority to develop effective prevention approaches and to identify new disease specific therapies to reduce disease mortality. The research proposed here has two components: (1) To characterize the genetic component in ovarian cancer development through epigenomic landscape; (2) to establish the functional relevance of genetic findings for clinical translation. This is a highly integrated multi-disciplinary research proposal, and these approaches to novel discovery and mechanistic understanding are desperately needed to advance our basic knowledge of this disease to develop clinical interventions that reduce mortality.

PI_NAMEs: PENG, PEI-CHEN  (contact)

PROGRAM_OFFICER_NAME: JOHNSON, RONALD L

PROJECT_TERMS: Acceleration;Advisory Committees;Affect;Area;Binding Sites;Biological Assay;BRCA1 gene;Buffers;California;Cancer Biology;cancer genetics;cancer genomics;cancer initiation;cancer predisposition;cancer type;career development;Cell Physiology;cell type;Cessation of life;ChIP-seq;Chromatin;Clinical;clinical translation;Code;cohort;Collaborations;Complex;complex biological systems;Computer Models;Computing Methodologies;Data;Data Science;Data Set;Development;Disease;DNA Sequence;DNA Sequence Alteration;Elements;Enhancers;Ensure;Environment;epigenetic regulation;epigenomics;Epithelial ovarian cancer;Etiology;experience;Faculty;Fellowship;Fostering;Future;Gene Expression;Genes;Genetic;genetic information;Genetic Risk;genetic variant;Genetic Variation;Genome;genome sequencing;genome wide association study;genome-wide;genome-wide analysis;genomic data;Genomic Segment;Genotype;Germ Lines;Germ-Line Mutation;Goals;Grant;Heritability;histone modification;Human Genetics;improved;insight;Interdisciplinary Study;Intervention;Knowledge;Knowledge acquisition;Laboratories;Learning;Los Angeles;Machine Learning;machine learning model;Malignant neoplasm of ovary;Malignant Neoplasms;Measurement;Medical center;Mentors;Modeling;Molecular Profiling;mortality;multiple omics;Mutation;Nature;next generation sequencing;Noise;Normal tissue morphology;novel;Nucleic Acid Regulatory Sequences;Ovarian;ovarian neoplasm;Penetrance;Phenotype;population based;Positioning Attribute;Postdoctoral Fellow;precursor cell;Prevention approach;Process;Productivity;professor;Prognosis;promoter;Proteins;Regulatory Element;Research;Research Personnel;Research Proposals;Research Training;risk variant;Science;Series;Somatic Mutation;success;Susceptibility Gene;Techniques;Technology;tenure track;TP53 gene;Training;Training Programs;transcription factor;Transcriptional Regulation;tumor;tumor progression;Tumor Tissue;tumorigenesis;Universities;Untranslated RNA;Variant;whole genome

PROJECT_TITLE: Identifying new drivers of ovarian cancer from the non-coding genome by converging germline risk variants and somatic mutations


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Lung;Orphan Drug;Pulmonary Fibrosis;Rare Diseases

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: PROJECT NARRATIVE Idiopathic pulmonary fibrosis (IPF) is a deadly disease caused by uncontrolled tissue fibrosis in the lungs. There are no FDA-approved drugs that cure or prevent disease progression. We propose to combine computational modeling with experiments study how fibroblasts and microvessel remodeling in the lung contribute to disease and to identify novel drugs and drug combinations that target these processes in order to effectively treat IPF.

PI_NAMEs: BARKER, THOMAS HARRISON;PEIRCE-COTTLER, SHAYN  (contact)

PROGRAM_OFFICER_NAME: GOMEZ, CHRISTIAN RENE

PROJECT_TERMS: Affect;Alveolar;American;Bayesian Analysis;Biological;Bleomycin;Blood capillaries;Blood Vessels;cell behavior;Cell Communication;Cells;Cessation of life;Cicatrix;Clinic;Clinical;Clinical Data;Clinical Trials;Computer Models;Computer Simulation;Country;Data;Death Rate;Deposition;Development;Diagnosis;Disease;Disease Progression;Drug Combinations;Drug Targeting;Drug usage;Endothelial Cells;Endothelium;Environment;experimental study;Extracellular Matrix;FDA approved;Fibroblasts;Fibrosis;Harvest;Heterogeneity;Histology;Human;human data;idiopathic pulmonary fibrosis;Impairment;KDR gene;kinase inhibitor;Lesion;Logic;Lung;lung lesion;Machine Learning;Mediating;Modeling;models and simulation;Molecular;mortality;mouse model;Mus;Myocardium;Myofibroblast;Nature;New Agents;new therapeutic target;nintedanib;novel;novel therapeutic intervention;novel therapeutics;Outcome;Output;Patients;Pericytes;Pharmaceutical Preparations;Phenotype;Phosphotransferases;Pirfenidone;Platelet-Derived Growth Factor;Platelet-Derived Growth Factor Receptor;pre-clinical;preclinical study;predicting response;predictive modeling;prevent;Process;Production;Progressive Disease;Publishing;pulmonary agents;Pulmonary Fibrosis;pulmonary function;pulmonary function decline;Research;response;Retina;Signal Pathway;Signal Transduction;Skeletal Muscle;Specific qualifier value;standard of care;Tamoxifen;Terminal Disease;therapy design;Time;Tissues;transcriptome sequencing;transcriptomics;Transforming Growth Factors;Translating;Validation;Vascular Endothelial Growth Factor Receptor-1;Vascular Endothelial Growth Factors

PROJECT_TITLE: Modeling to Design Treatments for Idiopathic Lung Fibrosis

STUDY_SECTION: MABS

STUDY_SECTION_NAME: Modeling and Analysis of Biological Systems Study Section[MABS]


ADMINISTERING_IC: GM

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: PITTSBURGH

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: The graduate-level “Interinstitutional Program in Cell and Molecular Biology” will focus on training in the research areas vital for understanding the basic mechanisms of human disease and preparing trainees to a variety of conventional and unconventional career tracks related to health sciences. The Program will focus on an urgent need to increase diversity in the scientific community, and the importance of enhancing ethics and rigor in research.

PI_NAMEs: BRODSKY, JEFFREY L.;MURRAY, SANDRA ANN (contact);WOOLFORD, JOHN L.

PROGRAM_OFFICER_NAME: HARTON, MARIE DEBORAHGAYNELLE

PROJECT_TITLE: Interinstitutional Program in Cell and Molecular Biology: A Graduate Training Path to Promote Traditional and Non-Traditional Professional Outcomes

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - A[TWD-A]


NIH_SPENDING_CATS: Diabetes

ORG_CITY: ANN ARBOR

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Increasing genetic evidence suggests that susceptibility to type 2 diabetes is linked to defects in the ability to make and store insulin. Several of the risk loci are linked to genes involved in the process generally described as “Endoplasmic Reticulum (ER) Quality Control”. This group of leading investigators are among the world’s experts in the ER quality control in insulin-producing cells, and this proposal directly relates such quality control to the pathogenesis of diabetes (as well as therapeutic approaches to ameliorate the disease).

PI_NAMEs: ARVAN, PETER  (contact);QI, LING ;TSAI, BILLY

PROGRAM_OFFICER_NAME: WANG, XUJING

PROJECT_TERMS: Anabolism;Animals;anterograde transport;Area;Autophagocytosis;Belief;Beta Cell;Biogenesis;Biological;biological adaptation to stress;Blood Glucose;cell dedifferentiation;Cell Physiology;Cells;Complex;Coupled;dalton;Data;Defect;Degradation Pathway;Development;Diabetes Mellitus;diabetes pathogenesis;diabetes risk;Disease;Disease Progression;Distal;Endoplasmic Reticulum;endoplasmic reticulum stress;Failure;follow-up;Functional disorder;Genes;Genetic;Glucose;Golgi Apparatus;Grant;Homeostasis;Hormones;Human;Hyperactivity;INS gene;Insulin;Insulin deficiency;islet;Knockout Mice;Link;Lysosomes;Maintenance;manufacture;Membrane;Messenger RNA;Mind;Modeling;Molecular;Mus;mutant;non-diabetic;Non-Insulin-Dependent Diabetes Mellitus;novel therapeutic intervention;Pathway interactions;Patients;Peptide Signal Sequences;Phenotype;Predisposition;preproinsulin;prevent;Process;Production;Proinsulin;protein degradation;Proteins;Qi;Quality Control;recruit;Research;Research Personnel;restraint;risk variant;Role;Route;Secretory Cell;secretory protein;Secretory Vesicles;signal sequence receptor;Site;Structure of beta Cell of islet;success;TGF Beta Signaling Pathway;Therapeutic;transcription factor;transcriptomics;Translations;Vesicle;Work;Youth

PROJECT_TITLE: Secretory Pathway Protein Degradation Maintains Insulin Biogenesis + Secretion


NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: NEW YORK

ORG_DEPT: PHARMACOLOGY

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: Public Narrative: This project will investigate the mechanism underlying HSC migration using next-generation cutting-edge mouse genetic technology. Our research will provide an innovative platform to study HSC biology for further understanding how blood cells are generated and regulated in mammals.

PI_NAMEs: DING, LEI ;YAZAWA, MASAYUKI  (contact)

PROGRAM_OFFICER_NAME: YEH, ALVIN TIEN-WEI

PROJECT_TERMS: Address;Adult;Bar Codes;base;Binding;Biological Process;Biology;Bioluminescence;Blood;Blood Cells;Bone Marrow;Bone Marrow Transplantation;Cell Lineage;Cells;Clinic;Clonal Hematopoietic Stem Cell;Codon Nucleotides;Communities;CRISPR/Cas technology;Development;Disease;Dissociation;DNA Binding Domain;Doxycycline;Enterobacteria phage P1 Cre recombinase;experience;experimental study;Fluorescence;Gene Expression;gene repression;Genes;Genetic;genetic manipulation;Genetic Recombination;genetic technology;Genetic Transcription;Genome engineering;Goals;Guide RNA;Hematopoiesis;Hematopoietic stem cells;HSF1;improved;In Vitro;in vivo;innovation;knock-down;knockout gene;Libraries;Life;Light;Lighting;Liver;Mammalian Cell;Mammals;Molecular;mouse genetics;Mus;mutant;Names;new technology;Newborn Infant;next generation;novel;Nuclear Localization Signal;nuclease;optogenetics;p65;Pathologic;Photoreceptors;Physiologic pulse;Reporter;Research;Resolution;RNA;self renewing cell;single-cell RNA sequencing;Site;small molecule;Sorting;spatiotemporal;Specificity;stem cell biology;stem cell migration;Stimulus;synthetic biology;System;Tamoxifen;Technology;Testing;Tetracyclines;Tissues;tool;Transcriptional Activation Domain;Work

PROJECT_TITLE: Developing Next Generation Genetics for Understanding Hematopoietic Stem Cell Biology

STUDY_SECTION: CMT

STUDY_SECTION_NAME: Cellular and Molecular Technologies Study Section[CMT]


NIH_SPENDING_CATS: Genetics;Kidney Disease

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative Loss of integrity of the kidney filtration barrier results in urinary protein loss, which accounts for approximately 80% of end stage kidney disease where nearly 700,000 patients in the United States require dialysis or await kidney transplantation. Understanding the biological mechanisms are necessary to prevent the progression of chronic kidney disease. In this grant proposal, we plan to elucidate the underlying components required to maintain a normally functioning filtration barrier so that potential novel treatments can be discovered in the near future.

PI_NAMEs: ISHIBE, SHUTA  (contact)

PROGRAM_OFFICER_NAME: SADUSKY, ANNA BURKART

PROJECT_TERMS: Address;Affect;Agonist;Applications Grants;Area;Biological;Biology;Cell Count;Cell Culture Techniques;Cell Cycle;Cell Differentiation process;Cell Size;Chronic Kidney Failure;Clathrin;Clathrin-Coated Vesicles;Data;Databases;Deterioration;Development;Dialysis procedure;disease model;DNA Repair;DNA Sequence Alteration;Doxycycline;ds-DNA;Effectiveness;End stage renal failure;Endosomes;Endothelial Cells;Evaluation;Excretory function;experimental study;Failure;FDA approved;Filtration;Functional disorder;Future;gene repair;Genes;Genetic;genetic approach;Genetically Engineered Mouse;glomerular basement membrane;glomerular filtration;glomerular function;Goals;Grant;Guanosine;Human;Human Genetics;Impairment;In Vitro;in vivo;Information Systems;Injury;Kidney;Kidney Diseases;Kidney Failure;Kidney Transplantation;knock-down;Knock-out;Knockout Mice;Ligands;Lipoprotein Receptor;lipoprotein receptor related protein 5;Maintenance;Mass Spectrum Analysis;Mediating;Membrane;Metabolic;Modality;Modeling;Molecular;mouse model;Mus;Nephrotic Syndrome;new therapeutic target;Nonhomologous DNA End Joining;novel;Pathogenesis;Pathologic;Pathway interactions;Patients;pharmacologic;Play;podocyte;Population;Positioning Attribute;precision medicine;prevent;Proteins;Proteinuria;Proteomics;Public Health;Regulation;Renal function;Renal glomerular disease;repaired;Residual state;Role;Secondary to;Shotguns;Signal Pathway;Signal Transduction;Small Interfering RNA;solute;Steroid-resistant idiopathic nephrotic syndrome;tandem mass spectrometry;Testing;Therapeutic;trafficking;transcriptome sequencing;United States;urinary;Urine;wasting;Water

PROJECT_TITLE: Role of LRP1 in Podocyte Biology

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


NIH_SPENDING_CATS: Cancer;Genetics;Immunotherapy

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

PHR: Cancer is treated with DNA damaging chemotherapy and radiation therapy (XRT). Cancer cells are sensitive to DNA damage as they divide rapidly and have often acquired mutations in mechanisms that safeguard genome stability. Immune cells are also sensitive to DNA damage as they divide extremely rapidly (<6 h). Since cancer is treated with combinations of DNA damaging chemotherapy, XRT and immunotherapy, we investigate new approaches to separate the impact of DNA damage on cancer and anti-tumor immune cells.

PI_NAMEs: BAKKENIST, CHRISTOPHER J. (contact)

PROGRAM_OFFICER_NAME: HU, ZHANG-ZHI

PROJECT_TERMS: Acceleration;Adenosine;anti-tumor immune response;ataxia telangiectasia mutated protein;Base Excision Repairs;Biological Availability;cancer cell;Cancer Model;Cancer Patient;cancer therapy;CD8-Positive T-Lymphocytes;CDC2 gene;Cell Cycle;Cell Cycle Checkpoint;Cell Cycle Kinetics;cell killing;Cells;Cessation of life;chemotherapy;Chemotherapy and/or radiation;Clinical Trials;CT26;Cyclin-Dependent Kinases;Cytidine;Data;DNA;DNA biosynthesis;DNA Damage;DNA Double Strand Break;DNA Integration;DNA Repair;DNA Repair Pathway;DNA replication fork;DNA Sequence;DNA-Directed RNA Polymerase;Dose Limiting;Excision;Excision Repair;Genetic Transcription;Genetically Engineered Mouse;Genome;Genome Stability;Genomic DNA;Goals;Guanosine;helicase;Immune;immune checkpoint blockade;Immune response;Immunologic Memory;Immunotherapy;In Vitro;in vivo;Inbred BALB C Mice;inhibitor;innovation;Interferons;Ionizing radiation;kinase inhibitor;Kinetics;Knock-out;Laboratories;Licensing;Lymphopenia;Malignant Neoplasms;MCM4 gene;Mediating;mouse model;Mus;Mutation;novel strategies;Phosphotransferases;Radiation therapy;repaired;Reporting;response;Ribonucleosides;Ribonucleotides;RNA;S phase;Signal Transduction;System;T cell response;T cell therapy;Testing;Thymidine;Toxic effect;transplant model;Transplantation;tumor;Tumor Immunity;Tumor-infiltrating immune cells;Uracil;uracil-DNA glycosylase;Uridine

PROJECT_TITLE: DNA damage response and cancer immunity


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Antimicrobial Resistance;Infectious Diseases;Natural Products

ORG_DEPT: CHEMISTRY

PHR: PROJECT NARRATIVE Approximately half of all drugs in use today come from organisms in the environment such as bacteria. However, because of issues including increasing levels of antibiotic resistance, we need new bacterial sources of these compounds to replenish the drug pipeline. This research will discover new therapeutically relevant compounds and associated biochemistry using bacteria that were missed during past drug discovery efforts due to their growth requirements.

PI_NAMEs: PURI, AARON WEBSTER (contact)

PROGRAM_OFFICER_NAME: BOND, MICHELLE RUEFFER

PROJECT_TERMS: Address;Anabolism;anti-cancer;Antibiotic Resistance;Antibiotics;Bacteria;Biochemical;Biochemistry;Biological;Carbon;carbon compound;Collection;drug discovery;Environment;Gases;Gene Cluster;Genetic;Genome;Genomics;Growth;Health;Human;In Vitro;in vivo;Knowledge;Libraries;metabolomics;Methane;Methods;Natural product discovery;Natural Products;Natural Source;novel;novel therapeutics;Organism;Peptides;Pharmaceutical Chemistry;Pharmaceutical Preparations;Postdoctoral Fellow;Production;programs;Reporting;Research;Ribosomes;scaffold;Source;Stable Isotope Labeling;Testing;Therapeutic;Time;tool;Work

PROJECT_TITLE: Methylotrophs: underexplored bacteria for discovering novel natural products and biochemistry


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Cancer;Digestive Diseases;Genetics;Liver Cancer;Liver Disease;Rare Diseases

ORG_CITY: CHICAGO

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: Project Narrative Translational dysregulation that enhances protein synthesis and oncogenic gene expression has emerged as a key process contributing to cancer evolution, including in hepatocellular carcinoma (HCC), the most common primary liver malignancy and a leading cause of cancer death worldwide. We have recently biochemically characterized the function of a key HCC-related gene, METTL5, as the 18S rRNA N6-methyladenosine (m6A) methyltransferase, and have shown that its loss markedly reduces cellular proliferation. Defining the role of METTL5 in regulating ribosome function and investigating the mechanism by which it supports proliferation and tumorigenesis will clarify our understanding of the link between METTL5 and HCC, providing a potential new drug target and contributing to our understanding of how rRNA modifications can dynamically regulate translational processes in relation to disease.

PI_NAMEs: SEPICH, CARALINE LEE (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: Affect;Apoptotic;base;Binding;Binding Sites;Biochemical;Biogenesis;Biological Assay;Cancer Etiology;cancer risk;Cell Cycle;cell growth;Cell Line;Cell Nucleolus;Cell Proliferation;cell type;Cells;Cellular Stress;Cessation of life;cofactor;Complex;congenital anomaly;Cytosol;Data;demethylation;Development;Disease;Down-Regulation;Enzymes;Event;Evolution;Fractionation;Future;Gene Expression;Genes;Goals;Growth;Hela Cells;hepatocellular carcinoma cell line;HepG2;Heterogeneity;High Pressure Liquid Chromatography;Image;Immunoprecipitation;innovation;Internal Ribosome Entry Site;Knock-out;Link;Luciferases;Malignant neoplasm of liver;Malignant Neoplasms;Mediating;Messenger RNA;Methylation;Methyltransferase;Modification;Monitor;mouse model;mRNA sequencing;Nature;new therapeutic target;Normal tissue morphology;novel;Nuclear;Oncogenes;Oncogenic;Open Reading Frames;overexpression;Pathogenesis;Pathway interactions;Patients;Phenotype;Phosphotransferases;Positioning Attribute;Primary carcinoma of the liver cells;Process;Production;Prognosis;Prognostic Factor;Proliferating;Protein Biosynthesis;Proteins;Proteome;Recycling;Regulation;Reporter;Research;response;Ribosomal Proteins;Ribosomal RNA;ribosome profiling;ribosome releasing factor;Ribosomes;ribosomopathy;RNA, Ribosomal, 18S;Role;Site;stoichiometry;Stress;Supporting Cell;Testing;therapy development;Transcript;transcriptome sequencing;Translating;translation factor;Translation Initiation;Translation Process;translational impact;translational potential;Translational Regulation;Translations;treatment strategy;tumor;tumorigenesis;Up-Regulation;Western Blotting;Xenograft procedure

PROJECT_TITLE: Investigating METTL5-regulated translational changes in hepatocellular carcinoma

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F08-M(20)L]


ORG_CITY: BOSTON

ORG_NAME: DANA-FARBER CANCER INST

ORG_STATE: MA

PHR: Narrative My laboratory is built on a thorough understanding of the BCL-2 family of proteins, which regulates apoptosis, a program of cellular suicide. We have had important success in guiding small molecule inhibitors of BCL-2, an anti-apoptotic protein, into the clinic, spurring successful clinical trial programs particularly in chronic lymphocytic leukemia and acute myelogenous leukemia. We are building on this success by using dynamic BH3 profiling to identify novel drugs that selectively induce pro-apoptotic signaling in a wide range of cancer types.

PI_NAMEs: LETAI, ANTHONY G (contact)

PROGRAM_OFFICER_NAME: LUO, RUIBAI

PROJECT_TERMS: Acute Myelocytic Leukemia;Amphipathic Alpha Helix;Apoptosis;Apoptotic;BCL1 Oncogene;BH3 Domain;BH3 peptide;cancer cell;cancer type;Cell Membrane Permeability;cell suicide;Cells;Cessation of life;chemotherapy;Chronic Lymphocytic Leukemia;Clinic;Clinical Trials;design;Disease;Disease remission;drug sensitivity;Drug usage;Family;Hour;human model;Immunooncology;in vivo;Induction of Apoptosis;inhibitor;interest;Laboratories;Liquid substance;Malignant Neoplasms;Measures;Mitochondria;mouse model;neoplastic cell;Non-Malignant;novel therapeutics;Oligopeptides;Oncologist;Outer Mitochondrial Membrane;Pharmaceutical Preparations;Phenotype;predictive marker;pro-apoptotic protein;programs;Protein Family;Proteins;Reading;Signal Transduction;small molecule inhibitor;Solid;Solid Neoplasm;Somatic Cell;success;Therapeutic;Therapeutic Index;tool;tumor

PROJECT_TITLE: Reading mitochondrial apoptotic signaling to identify active cancer therapeutics


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Esophageal Cancer;Genetics;Prevention;Rare Diseases

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE Esophageal adenocarcinoma is a cancer with poor outcomes when diagnosed after the onset of symptoms. It arises in a precancerous condition called Barrett’s esophagus. In this proposal, we aim to validate a non- endoscopic approach to the diagnosis of Barrett’s esophagus, dysplasia and adenocarcinoma, using a capsule sponge combined with DNA markers, to enable early diagnosis, prevention and treatment of this lethal cancer.

PI_NAMEs: IYER, PRASAD G. (contact);KISIEL, JOHN

PROGRAM_OFFICER_NAME: YOUNG, MATTHEW R

PROJECT_TERMS: Address;Adenocarcinoma;Age;Algorithms;Barrett Esophagus;Biological Assay;biomarker panel;Biopsy Specimen;bisulfite sequencing;Body mass index;candidate marker;capsule;Case/Control Studies;Chronic;Clinic;Clinical;cohort;cost;Cytology;Data;Deglutition;Demographic Factors;Dependence;design;Detection;Development;Devices;Diagnosis;Diagnostic;DNA;DNA Markers;DNA Methylation;Dysplasia;Early Diagnosis;effective therapy;Effectiveness;Eligibility Determination;Endoscopy;Esophageal Adenocarcinoma;Esophageal Intraepithelial Neoplasia;Esophageal mucous membrane;Esophagus;Ethnic Origin;Evaluation;FDA approved;Gastroesophageal reflux disease;Health system;High grade dysplasia;Histology;Histopathology;Image;improved;Individual;innovation;Intestinal Metaplasia;Lasers;Malignant Neoplasms;Measures;Medical center;meetings;microendoscopy;minimally invasive;Molecular;molecular marker;novel;nursing administration;Oral cavity;Outcome;Participant;Patients;Polyurethanes;Population;Porifera;Precancerous Conditions;prediction algorithm;Predictive Value;prevent;Prevention;Prevention strategy;primary care clinic;Recommendation;Recording of previous events;Reflex action;Research;Sampling;screening;Sensitivity and Specificity;sex;Smoking;Specimen;Stomach;Surveillance Program;Symptoms;Techniques;Testing;Tissue Sample;Uncertainty;Validation;VAV3 gene;Work

PROJECT_TITLE: Minimally Invasive Molecular Approaches for the Detection of Barrett’s Esophagus and Esophageal Adenocarcinoma

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-T(90)]


NIH_SPENDING_CATS: Congenital Structural Anomalies;Genetics;Kidney Disease;Pediatric;Polycystic Kidney Disease

ORG_DEPT: GENETICS

PHR: Nephronophthisis (NPHP) is a recessive renal ciliopathy characterize by interstitial fibrosis and cysts. Although NPHP accounts for a significant portion of end stage renal disease in children and young adults, currently no targeted therapy is available. This project focuses on the NPHP gene Nphp2.

PI_NAMEs: SUN, ZHAOXIA  (contact)

PROGRAM_OFFICER_NAME: MARIC-BILKAN, CHRISTINE

PROJECT_TERMS: Autosomal Dominant Polycystic Kidney;Biochemical;Biological Assay;cell type;Cells;Child;Cilia;ciliopathy;cilium biogenesis;Clustered Regularly Interspaced Short Palindromic Repeats;Coupled;Cyst;Cystic kidney;Cystic Kidney Diseases;Data;Development;Disease;Disease Progression;End stage renal failure;Epithelial Cells;Epithelial cyst;Epithelial-Stromal Communication;Epithelium;Etiology;Excision;Extracellular Matrix Proteins;Feedback;Fibroblasts;Fibrosis;Foundations;Future;Gene Silencing;Generations;Genes;Genetic;Genetic Transcription;Grant;in vivo;infancy;insight;interstitial;interstitial cell;Investigation;Kidney;kidney cell;kidney fibrosis;Knock-out;Knockout Mice;Knowledge;Left;Ligands;Link;Mediating;Messenger RNA;Modeling;Molecular;mouse model;Mus;Mutagenesis;mutant;Myofibroblast;Nature;Neonatal;Nephronophthisis;novel;Outcome;Pathway Analysis;Pathway interactions;Patients;Phenotype;Physiological;PKD1 gene;PKD2 protein;Play;polycystic kidney disease 1 protein;Post-Transcriptional Regulation;posttranscriptional;Proteins;Proteomics;renal epithelium;Research;response;Role;Severities;Signal Transduction;smoothened signaling pathway;Stromal Cells;Symptoms;targeted treatment;Testing;Tissues;transcriptomic profiling;translatome;Work;young adult;Zebrafish

PROJECT_TITLE: NPHP2 in ciliary function, renal fibrosis and cyst formation


NIH_SPENDING_CATS: Asthma;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Lung;Nutrition;Obesity;Pediatric;Physical Rehabilitation;Rehabilitation

ORG_CITY: DURHAM

ORG_DEPT: PEDIATRICS

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Project Narrative Inspiratory training (IT) has demonstrated clinical benefits in numerous chronic cardiopulmonary conditions, and consistently improves breathlessness and exercise capacity. Recently studies suggest IT reduces dyspnea and respiratory symptoms in pediatric asthma. Obesity is an increasingly prevalent factor complicating pediatric asthma management. The mechanism(s) driving the clinical benefits of IT remain wholly unknown. This project leverages our group's expertise with IT and pediatrics to study the mechanisms underlying pediatric obese asthma in general and IT in particular.

PI_NAMEs: LANG, JASON E. (contact)

PROGRAM_OFFICER_NAME: FREEMER, MICHELLE M

PROJECT_TERMS: 17 year old;Address;Adherence;Adult;airway inflammation;Anti-Inflammatory Agents;arm;Asthma;asthmatic;Automobile Driving;Chest;Child;Childhood;Childhood Asthma;Chronic pulmonary heart disease;Clinical;Communities;conventional therapy;Coughing;Data;design;Doctor of Philosophy;Dose;Dyspnea;Esthesia;exercise capacity;exercise physiologist;experience;Fatigue;Fostering;Functional disorder;Impairment;improved;Inhalation;Intervention;Knowledge;Laboratory Finding;Link;Lung;Masks;Measures;Mechanics;Morbidity - disease rate;multidisciplinary;Muscle;Muscle Fatigue;Muscle function;muscle strength;Non obese;non-drug;novel;Obesity;obesity in children;obesity-associated asthma;Oscillometry;Participant;Pediatrics;Pharmaceutical Preparations;Phase II/III Trial;phase III trial;Phenotype;Play;Plethysmography;pressure;Prevalence;Public Health;Qualifying;Randomized;recruit;Regimen;rehabilitation science;Rehabilitation therapy;Reporting;Research;Research Personnel;Residual volume;Resistance;Respiration;Respiratory Mechanics;Respiratory Signs and Symptoms;Respiratory System;response;Rest;Risk Factors;Role;Sampling;Schools;stem;Symptoms;Techniques;Testing;Thinness;Training;Training Programs;treatment comparison;treatment response;trend;trial design;Wheezing;Work;Youth

PROJECT_TITLE: Mechanistic Study of Inspiratory Training in Childhood Asthma

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


ADMINISTERING_IC: DA

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Mental Health;Mental Illness;Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Prevention;Social Determinants of Health;Substance Misuse;Substance Misuse Prevention

ORG_CITY: PHILADELPHIA

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE Strategies to prevent opioid overdose which impact large groups of opioid users at multiple levels of influence are acutely needed. The broad objective of this K01 proposal is to investigate modifiable neighborhood factors which impact opioid misuse and mental health and which may contribute to opioid overdose using a mix of both quantitative and qualitative methods. The proposed research and training will lead to a subsequent R01 proposal that formally tests implementation strategies and effectiveness of neighborhood-level interventions for overdose prevention.

PI_NAMEs: NESOFF, ELIZABETH  (contact)

PROGRAM_OFFICER_NAME: COLLIER KIDEMU, KEVA WONTORIA

PROJECT_TERMS: Acute;Address;Adult;Affect;Anxiety;Anxiety Disorders;Area;Arousal;Bayesian Modeling;Behavior;built environment;career;Characteristics;Chicago;Cities;Communities;comparative;Consumption;cost;Crack Cocaine;Data;design;Deterioration;Development;Diagnosis;diagnostic criteria;Disease;Drug abuse;Drug usage;Drug user;Economics;Educational workshop;Environment;Environmental Health;Equation;Ethics;Exhibits;experience;fentanyl use;Goals;hands on research;harassment;Health;heroin use;Home;implementation strategy;implementation/effectiveness;injection drug use;Injury;injury-related death;Intervention;Interview;Intoxication;Knowledge;Lighting;Link;Location;Major Depressive Disorder;Major Mental Illness;marginalization;Marijuana;Measures;Mediating;Mediator;Mental association;Mental Depression;Mental disorders;Mental Health;Mentors;Methods;Modeling;Mood Disorders;multidisciplinary;Neighborhoods;New York City;novel strategies;Opioid;opioid misuse;opioid overdose;opioid use;opioid use disorder;opioid user;Overdose;overdose death;overdose prevention;overdose risk;Pain management;Pharmaceutical Preparations;Policies;Population;prescription opioid;Prevalence;prevent;Prevention;Psychiatric epidemiology;Public Health;Qualitative Methods;Reporting;Research;Research Activity;Research Methodology;residence;Risk;Risk Factors;Safety;Scientist;skills;social;social deficits;social group;Social Interaction;Social isolation;Statistical Data Interpretation;Stigmatization;stressor;Structure;Testing;theories;Training;Translating;Travel;trend;United States;verbal;violence prevention

PROJECT_TITLE: Neighborhoods, Mental Health, and the Prevention of Opioid Overdose: A Mixed Methods Approach

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-J(04)]


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Cervical Cancer;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Prevention;Primary Health Care;Sexually Transmitted Infections;Social Determinants of Health;Women's Health Research

ORG_DEPT: OBSTETRICS & GYNECOLOGY

PHR: NARRATIVE HIV, cervical cancer and human papillomavirus (HPV) are interrelated health conditions with intersecting stigmas that may influence women’s uptake of prevention services. We will evaluate the effectiveness of a novel stigma-responsive service delivery model for HPV-based cervical cancer screening called “Elimisha HPV” among women in a high HIV-prevalence area of Kenya. If effective, this may serve as a new model for cervical cancer screening as well as a new paradigm for comprehensive, stigma-responsive service delivery packages for people living with HIV.

PI_NAMEs: HUCHKO, MEGAN J. (contact)

PROGRAM_OFFICER_NAME: BANSAL, GEETHA PARTHASARATHY

PROJECT_TERMS: Address;Anti-Retroviral Agents;Area;Awareness;Biological;cancer risk;care outcomes;Caring;cervical cancer prevention;Cervical Cancer Screening;Characteristics;Clinic;Collection;Communication;Communities;Community Health;County;Data;design;Diagnosis;Discrimination;Education;Educational Intervention;Educational Materials;effective therapy;Effectiveness;effectiveness evaluation;effectiveness testing;Epidemiology;Focus Groups;follow-up;Fright;Government;Health;Health care facility;Healthcare;HIV;HPV positive;Human Development;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;implementation strategy;implementation/effectiveness;Individual;infection risk;Infrastructure;Institution;Intervention;Interview;Kenya;Language;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Measurement;Methods;Modeling;novel;Outcome;Outpatients;outreach;Pamphlets;Patient-Centered Care;peer;Perception;Persons;Prevalence;prevent;prevention service;programs;randomized, clinical trials;response;Risk;Risk Factors;screening;Screening for cancer;screening services;service delivery;Service delivery model;Sex Behavior;social stigma;Social support;standard of care;Stigmatization;success;synergism;Testing;Text Messaging;therapy design;tool;Training;treatment arm;uptake;volunteer;Woman;women's outcomes;Work;World Health Organization

PROJECT_TITLE: A stigma responsive service delivery model for HPV-based screening among women living with HIV

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


PHR: Project Narrative: The research performed by students in the CMB program addresses fundamental questions about the nation’s pressing public health concerns, including prevalent chronic disorders (e.g., cancer, diabetes, heart disease), neurological conditions (e.g., Alzheimer’s, epilepsy, addiction), and infectious diseases (e.g., COVID, MRSA). Training a diverse pool of students, using evidence-based approaches that combine broad exposure and focused training of students in cellular and molecular approaches, effective mentor training, and program evaluation at multiple levels, fills a critical need for producing well-trained scientists in the biomedical workforce who work to advance fundamental knowledge in areas relevant to advancing health, reducing illness and improving the quality of human life.

PI_NAMEs: BRENNER, JOHN CHADWICK (contact)

PROGRAM_OFFICER_NAME: NELSON, SHAKIRA M

PROJECT_TITLE: Cellular and Molecular Biology at Michigan


NIH_SPENDING_CATS: Genetics

ORG_CITY: IRVINE

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: Alternative pre-mRNA splicing is a crucial component of establishing appropriate gene expression programs that are unique to tissues and differentiated cell types. Defects in alternative splicing are known to associate with many human diseases. In this project we will analyze the mechanisms of regulated alternative splicing using a combination of experimental and computational approaches to provide detailed molecular insights into the control of gene expression and to identify novel disease targets.

PI_NAMEs: HERTEL, KLEMENS J (contact)

PROGRAM_OFFICER_NAME: CZAPLINSKI, KEVIN

PROJECT_TERMS: 5' Splice Site;Address;Alternative Splicing;Biochemical;Bioinformatics;Biological;Biological Assay;Biology;cancer type;Cell Differentiation process;cell type;Cells;cis acting element;Code;combinatorial;conformer;Defect;Disease;Elements;Essential Genes;Event;Excision;Exons;Gene Expression;Gene Expression Profile;Generations;Genes;Genetic Diseases;genetic regulatory protein;Genetic Transcription;Goals;Growth;Heterogeneous-Nuclear Ribonucleoproteins;human disease;Human Genetics;Human Genome;improved;insight;Introns;Kinetics;Knock-in;Knock-out;Label;Lead;Link;Mediating;Messenger RNA;Metabolic;Methods;Modeling;Molecular;Molecular Biology;mRNA Precursor;mRNA Stability;Mutation;novel;Outcome;Pathway interactions;Positioning Attribute;premature;Process;programs;Proteins;Publishing;radioligand;reconstitution;Regulation;Reporter;Repression;Research;RNA;RNA Processing;RNA Splicing;Role;Site;Spliceosome Assembly Pathway;Structure;synthetic biology;System;Techniques;Testing;therapeutic target;tissue culture;Tissues;Transcript;transcriptomics;Translating;Translations;U1 Small Nuclear Ribonucleoprotein;Variant;Work

PROJECT_TITLE: Regulation and impact of alternative splicing in biology and disease

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Bioengineering;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

ORG_DEPT: ORTHOPEDICS

PHR: Narrative Injuries to tendons and ligaments make up almost half of all musculoskeletal injuries yet the signaling pathways that regulate tissue formation during development and following injury remain poorly understood. This proposal seeks to fill this gap in knowledge using a series of novel mouse models to elucidate the functional role of hedgehog signaling in tendon-to-bone repair following anterior cruciate ligament reconstruction.

PI_NAMEs: DYMENT, NATHANIEL A. (contact)

PROGRAM_OFFICER_NAME: MARQUITZ, ARON

PROJECT_TERMS: Ablation;Adult;Agonist;antagonist;Anterior;anterior cruciate ligament reconstruction;Automobile Driving;Biological Assay;Biology;Biomechanics;bone;bone marrow mesenchymal stem cell;bone repair;Cell Differentiation process;Cells;Clinical;Clinical Treatment;Collagen Fiber;Data;Day Surgery;Deposition;Development;Drug Delivery Systems;Erinaceidae;Fibrocartilages;Future;gain of function;Genes;Genetic;Growth and Development function;healing;improved;Injury;innovation;Knowledge;LacZ Genes;Lasers;ligament injury;Ligaments;loss of function;Measures;Mechanics;Mesenchymal Stem Cells;Methods;mineralization;Minerals;Modeling;mouse model;Mus;musculoskeletal injury;novel;novel therapeutics;Osteocytes;Outcome;Pathway interactions;Pharmaceutical Preparations;pharmacologic;Phenotype;Process;Production;progenitor;Proliferating;Proteoglycan;Qualifying;reconstruction;repair model;repaired;Reporter;Reporting;response;Role;Scientist;Series;Signal Pathway;Site;smoothened signaling pathway;spatiotemporal;Sports Medicine;stem cell expansion;stem cell proliferation;Surgical Models;Tamoxifen;tendon graft;Tendon Injuries;Tendon structure;Testing;Therapeutic;Tissues;Transgenic Mice

PROJECT_TITLE: Functional role and therapeutic potential of hedgehog signaling in tendon-to-bone repair

STUDY_SECTION: SBSR

STUDY_SECTION_NAME: Skeletal Biology Structure and Regeneration Study Section[SBSR]


ADMINISTERING_IC: NS

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Aging;Bioengineering;Brain Disorders;Cerebrovascular;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hematology;Nanotechnology;Neurosciences;Stroke

ORG_CITY: SAINT LOUIS

ORG_NAME: UNANDUP, LLC

ORG_STATE: MO

PHR: There are more than 700,000 annual acute ischemic stroke (AIS) events in the US which result in nearly 150,000 deaths, making AIS the fifth leading cause of death and the leading cause of neurological disability. Although thrombectomy is the standard of care for those diagnosed with a treatable large vessel occlusion in the anterior circulation, improvements in thrombolysis are needed given that most AIS events are not amenable to thrombectomy. UNandUP (short for “Unmet Needs and Underserved Populations”) has invented a safe and effective nanoparticle-based magnetic thrombolysis platform which can be applied to nearly all AIS victims.

PI_NAMEs: CREIGHTON, FRANCIS MILTON (contact);DERDEYN, COLIN PIETER

PROGRAM_OFFICER_NAME: GILCHRIST, FLOY ANNETTE

PROJECT_TERMS: 3D Print;absorption;Acceleration;Acute;Alteplase;Ambulances;American;Animal Model;Animals;Anterior;Biodistribution;Biological;Biological Assay;biomaterial compatibility;Blood;Blood coagulation;Blood flow;Brain;Caring;Cause of Death;Cessation of life;Circulation;Coagulation Process;cost;Custom;Cyclic GMP;Cytolysis;Data Set;Deterioration;Development;Diagnosis;Diffusion;disability;Dose;Drug Kinetics;Economic Burden;efficacy study;Eligibility Determination;Embolism;Ensure;Family suidae;FDA approved;Fibrinogen;Fibrinolytic Agents;Goals;Half-Life;hemodynamics;Hemorrhage;Hospitals;Hour;Human;improved;In Vitro;in vivo;Infusion procedures;invention;Iron;iron oxide;Ischemic Stroke;Knowledge;Location;Magnetic nanoparticles;Magnetism;Marketing;Measures;Mechanics;meetings;Metabolism;Methods;millimeter;Modeling;Morphology;nanoparticle;Neurological disability;Neurological outcome;novel;Organ;Palliative Care;Pathway interactions;Patient Transfer;Patients;Performance;Pharmaceutical Preparations;Pharmacodynamics;Pharmacologic Substance;Plasma;portability;prevent;Procedures;Process;programs;prototype;Publishing;Rattus;Reaction;Reperfusion Therapy;Resolution;response;Risk;Rodent;Safety;safety assessment;safety study;Sex Distribution;Silicon Dioxide;Speed;standard of care;Stroke;stroke event;stroke intervention;stroke outcome;stroke therapy;stroke victims;success;Surface;System;Techniques;Technology;Thrombectomy;thrombolysis;Time;tool;Underserved Population;United States

PROJECT_TITLE: Low-Dose Magneto-Thrombolysis to Expand Stroke Care

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-NV-C(10)B]


ORG_CITY: OKLAHOMA CITY

ORG_NAME: OKLAHOMA MEDICAL RESEARCH FOUNDATION

ORG_STATE: OK

PHR: Project Narrative The loss of skeletal muscle mass can occur through genetic or external factors such as disease, hospitalization or aging; and affects the quality of life for millions of people. In this proposal, I will be studying a novel and potentially important protein (F-box and leucine-rich repeat protein 22) involved in the development of skeletal muscle atrophy. The approach taken in this proposal has great potential for understanding the role of E3 ubiquitin ligases in the regulation of skeletal muscle mass and function and the findings may provide a basis for new therapeutic strategies for the treatment of muscle atrophy.

PI_NAMEs: HUGHES, DAVID C (contact)

PROGRAM_OFFICER_NAME: LINDHURST, MARJORIE JEAN

PROJECT_TERMS: Acute;Affect;Aging;alpha Actinin;Atrophic;Chronic Disease;Complex;Data;Denervation;Direct Lytic Factors;Disease;Electroporation;Exercise;F Box Domain;Faculty;Family member;Fasting;filamin;Genes;Genetic;genetic manipulation;Genetic Transcription;Growth;Hindlimb;Homeostasis;Hospitalization;Human Genome;Hypertrophy;improved;in vivo;Individual;Injury;Iowa;knock-down;Leucine;leucine-rich repeat protein;Mediating;Mentored Research Scientist Development Award;Mentors;Modeling;Molecular;mRNA Expression;multicatalytic endopeptidase complex;Muscle;Muscle Fibers;muscle form;Muscle function;muscle physiology;Muscle Proteins;Muscular Atrophy;Myocardium;myogenesis;Myogenic Regulatory Factors;Myogenin;Myopathy;Nerve Crush;novel;novel therapeutic intervention;overexpression;Persons;Phenotype;Plasmids;Positioning Attribute;Post Translational Modification Analysis;Process;Promoter Regions;protein degradation;Protein Isoforms;Proteins;Proteomics;Quality of life;Recording of previous events;Regulation;Research;Research Personnel;RNA Interference;Role;Skeletal Development;Skeletal Muscle;skeletal muscle wasting;skills;Stimulus;Structure;System;Techniques;Testing;Therapeutic;Therapeutic Intervention;Tissues;tool;treatment strategy;Ubiquitin;ubiquitin-protein ligase;Ubiquitination;Universities

PROJECT_TITLE: The role of Fbxl22 in the regulation of skeletal muscle mass

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Liver Disease;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Women's Health Research

ORG_CITY: KINGSTON

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF RHODE ISLAND

ORG_STATE: RI

PHR: Liver plays important roles in maintaining normal pregnancy. Pregnant women with liver diseases have increased risk for developing pregnant complications including preterm birth and stillbirth. However, our current understanding on the underlying mechanisms and treatment option are limited. This proposal is aiming at filling in those gaps to investigate the underlying mechanisms of increased pregnancy complications in pregnant women with liver diseases and develop novel mechanism-based interventions to reduce or prevent pregnancy complications in those affected populations.

PI_NAMEs: DENG, RUITANG  (contact)

PROGRAM_OFFICER_NAME: BURGESS-BEUSSE, BONNIE L

PROJECT_TERMS: Acids;Affect;Agonist;Animal Model;Bile Acid Biosynthesis Pathway;Bile Acids;bile salts;Carbon Tetrachloride;Characteristics;Cholestasis;Cholestyramine;Cholic Acids;Clinical;design;Dose;Drug Modulation;Energy Metabolism;Enterohepatic Circulation;Estrogens;Etiology;experience;experimental study;farnesoid X-activated receptor;FDA approved;Fetus;G-Protein-Coupled Receptors;General Population;High Fat Diet;Homeostasis;Hormones;improved;Infant;Inflammation;Intervention;intrahepatic cholestasis of pregnancy;Knock-out;Link;Liver;Liver diseases;liver injury;Mediating;Metabolic;Modeling;Morbidity - disease rate;mortality;Mothers;mouse model;Mus;Muscle Contraction;myometrium;Newborn Infant;non-alcoholic fatty liver disease;novel;Nutritional;Organ;Patients;Pharmaceutical Preparations;Play;Population;Predisposition;Pregnancy;Pregnancy Complications;pregnant;Pregnant Women;Premature Birth;Prevalence;prevent;Pump;receptor;Receptor Activation;Regulation;Repression;Research;Risk;Role;Serum;Signal Pathway;Signaling Molecule;stillbirth;Structure;Survival Rate;Testing;Therapeutic;Therapeutic Effect;Tissues;Woman

PROJECT_TITLE: Liver Diseases and Pregnancy Complications

STUDY_SECTION: PN

STUDY_SECTION_NAME: Pregnancy and Neonatology Study Section[PN]


PHR: Project Narrative The proposed study is key to reducing burden and to improving the quality of thyroid cancer survivorship. The findings from this study will have implications for patients, physicians, and policy makers with potential for a pivotal change in long-term thyroid cancer surveillance.

PI_NAMEs: HAYMART, MEGAN RIST (contact)

PROGRAM_OFFICER_NAME: GALLICCHIO, LISA M

PROJECT_TERMS: Age;Asian;Cancer Patient;cancer recurrence;Cancer Survivor;Cancer Survivorship;cancer type;Caring;Categories;Characteristics;cohort;Collaborations;cost;County;Data;Data Collection;Data Set;Databases;Development;Diagnosis;evidence base;experience;Female;Frequencies;Health Care Costs;health data;high risk;High-Risk Cancer;Hispanic;Image;improved;Incidence;Institution;Longterm Follow-up;Los Angeles;Malignant neoplasm of thyroid;Malignant Neoplasms;Michigan;Modeling;Molecular;mortality;neoplasm registry;Pacific Islander;Pathology Report;Pathway interactions;patient oriented;Patient Selection;Patients;Phenotype;Physicians;Policy Maker;population based;Positioning Attribute;Positive Test Result;Precision Health;predictive modeling;Quality of life;Recurrence;Registries;Reporting;Resources;Risk;risk prediction model;risk stratification;Rural;Secondary to;SEER Program;side effect;Site;Survivors;Symptom Burden;Test Result;Testing;Time;Treatment Side Effects;Universities;unnecessary treatment;Validation;Woman;young adult;young woman

PROJECT_TITLE: Risk-stratified care for thyroid cancer survivors

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 HSS-B (90)]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Depression;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Mental Illness;Pediatric;Prevention;Serious Mental Illness;Social Determinants of Health;Suicide;Suicide Prevention

ORG_DEPT: PSYCHIATRY

PHR: PROJECT NARRATIVE Suicide exacts a heavy toll among adolescents living with HIV (ALWH) in Malawi where suicide prevention efforts are lagging. This proposed study will 1) enhance the Friendship Bench (FB) depression model with a culturally-adapted Safety Planning (SP) intervention to reduce suicidal ideation and behaviors among ALWH in Malawi; 2) evaluate the implementation and preliminary effectiveness of the FB+SP model through a pilot randomized controlled trial (RCT); and 3) build the capacity of researchers and policy makers to use evidence to advance decriminalization efforts. This proposal will critically advance suicide prevention in Malawi, build capacity, and generate the preliminary evidence needed to test the FB+SP model in a large-scale R01 RCT.

PI_NAMEs: KULISEWA, KAZIONE ;STOCKTON, MELISSA ANN (contact)

PROGRAM_OFFICER_NAME: VEDHAM, VIDYA

PROJECT_TERMS: Acute;Address;Adolescent;Advocate;Africa;Africa South of the Sahara;barrier to care;Caring;Cause of Death;child depression;Chronic;Clinical;Cognitive Therapy;Collaborations;common symptom;Communication;community advisory board;community based participatory approach;comorbid depression;Coping Skills;Counseling;Country;Data;depression model;Development;Educational process of instructing;Educational workshop;Effectiveness;Enrollment;Event;evidence base;Evidence based intervention;Evidence based treatment;Family member;Feeling suicidal;Friends;Friendships;Goals;Health;Health system;help-seeking behavior;HIV;HIV-infected adolescents;Human Resources;implementation evaluation;improved;Individual;innovation;Intervention;Investments;Learning;Lived experience;low and middle-income countries;Malawi;meetings;member;Mental Depression;Mental disorders;Mental Health;Modeling;Mood Disorders;mortality;Patients;pilot test;Policy Maker;Policy Making;Prevalence;Prevention;Prevention program;preventive intervention;Problem Solving;problem solving therapy;programs;Protocols documentation;Psychiatrist;psychosocial stressors;Public Health;Randomized;Randomized, Controlled Trials;reducing suicide;Reporting;Research;Research Personnel;Resources;Safety;Services;skills;social culture;social stigma;Specialist;Stigmatization;Structure;suicidal;suicidal adolescent;suicidal behavior;suicidal risk;Suicide;Suicide attempt;Suicide prevention;symposium;Testing;therapy design;Thinking;Training;treatment as usual;Youth

PROJECT_TITLE: Suicide Assessment and Feasible Evidence-based Treatments for Youth Living with HIV: SAFETY Planning

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-C (01)]


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Hepatitis;Liver Disease

PHR: PROJECT NARRATIVE/LAY SUMMARY This proposal examines the mechanisms of liver injury and inflammation in nonalcoholic fatty liver disease by employing models related to obesity. We propose that liver endothelial cells exposed to excess circulating toxic lipids such as saturated free fatty acids undergo structural and functional alterations that we refer to as endotheliopathy, which increases vascular resistance and enhances white blood cell infiltration into the liver, promoting portal hypertention and liver inflammation. The results of the proposal have the potential to identify new mechanisms of liver inflammation and portal hypertention in nonalcoholic fatty liver disease (the most common liver disease in children and adults), and discover new therapeutic targets for this disease.

PI_NAMEs: IBRAHIM, SAMAR  (contact)

PROGRAM_OFFICER_NAME: GARCIA, MARTHA

PROJECT_TERMS: Adult;Affect;Antibody Therapy;Biological Assay;Cell Adhesion;Cell model;cell type;Cells;Cellular Stress;Child;Cytoskeletal Proteins;Cytoskeleton;Data;Diet;Disease;Endothelial Cells;Endothelium;Exposure to;Focal Adhesions;Functional disorder;functional outcomes;Gene Expression Profile;Generations;Genetic;Genetic Transcription;glycogen synthase kinase 3 beta;Glycogen Synthase Kinases;Hepatocyte;Human;Impairment;In Vitro;in vitro Model;in vivo;in vivo Model;Infiltration;Inflammatory;Inflammatory Response;inhibitor;insight;Intercellular adhesion molecule 1;Intercellular Adhesion Molecules;intrahepatic;JUN gene;Leukocytes;Lipids;Liver;Liver diseases;Liver Fibrosis;liver inflammation;liver injury;Mediating;Mediator;Metabolic dysfunction;migration;Modeling;Molecular;mouse model;multiple omics;Mus;Myeloid Cells;myosin light chain 2;neutralizing antibody;new therapeutic target;non-alcoholic fatty liver disease;Nonesterified Fatty Acids;novel;Obesity;Oral;Pathogenesis;Pathogenicity;Pathway interactions;Patients;pharmacologic;Phenotype;phosphoproteomics;Phosphorylation;Phosphotransferases;Portal Hypertension;Portal Pressure;Post-Translational Regulation;Public Health;recruit;Regulation;Repression;Role;Severity of illness;Signal Transduction;Steatohepatitis;Sterility;Stress;Stress Fibers;Testing;Therapeutic;therapeutic target;transcription factor;Transcriptional Regulation;transcriptomics;Up-Regulation;Vascular resistance;Vasodilation;Work

PROJECT_TITLE: Lipotoxicity and Liver Inflammation

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


ADMINISTERING_IC: HD

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Cerebral Palsy;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Rehabilitation

ORG_CITY: ALLENDALE

ORG_NAME: GRAND VALLEY STATE UNIVERSITY

PHR: Project Narrative For children with severe cerebral palsy, a powered wheelchair (PWC) may provide their only option for functional mobility and independence. PWC use is often restricted to a small percentage of children who can quickly demonstrate proficient PWC skills within a single 30- minute PWC trial. This 2-arm, parallel group, single blinded, pre-test-post-test randomized controlled trial will test our hypothesis that an 8-week PWC skills training intervention will produce greater improvements in children’s PWC skills capacity immediately after the intervention and at an 8-week follow-up assessment.

PI_NAMEs: KENYON, LISA  (contact)

PROGRAM_OFFICER_NAME: NITKIN, RALPH M

PROJECT_TERMS: Academic Research Enhancement Awards;Age;arm;Augmentative and Alternative Communication;Automobile Driving;Caregivers;Cerebral Palsy;Child;Child Support;Classification;Climacteric;clinically significant;Communication;communication device;Control Groups;Custom;design;disability;Educational Intervention;empowerment;evidence base;Exclusion;Exhibits;follow up assessment;follow-up;functional independence;Funding;Health;Health Professional;improved;innovation;International;Intervention;Joystick;Learning;Manual wheelchair;Measures;mobility aid;Occupational;Outcome;Parents;Perception;Performance;performance based measurement;Phase;post intervention;Powered wheelchair;Pre-Post Tests;professional students;Random Allocation;Randomized, Controlled Trials;Research;routine care;Safety;Single-Blind Study;skills;skills training;Small Business Innovation Research Grant;Standardization;System;Testing;Time;tool;Training;Training Activity;undergraduate student;United States National Institutes of Health;Universities;Waiting Lists;Walking;Wheelchairs;Work

PROJECT_TITLE: Em-power: Maximizing Functional Independence for Children with Severe Cerebral Palsy

STUDY_SECTION: MFSR

STUDY_SECTION_NAME: Motor Function, Speech and Rehabilitation Study Section[MFSR]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research

ORG_CITY: AMES

ORG_NAME: IOWA STATE UNIVERSITY

ORG_STATE: IA

PHR: Through this project, we aim to increase awareness of the importance of evidence-based decision making and enable biomedical science administrators and other stakeholders with the tools and skill sets to make program evaluation an on-going, integral component of research training programs from the beginning rather than a one-time event. Our proposed solution highlights the strength of decision-making based on systematically collected evidence that improves the quality of biomedical research training programs and therefore contributes to the development of biomedical research and global health. Our long-term goal, therefore, is to make program evaluation a seamless component of biomedical research training programs by equipping the stakeholders with skills and knowledge required for planning and conducting program evaluation through online educational modules.

PI_NAMEs: KARABULUT ILGU, ALIYE  (contact)

PROGRAM_OFFICER_NAME: STAMM, JOYCE CHIN-CHIN NG

PROJECT_TERMS: Address;Administrator;Association of American Medical Colleges;Attitude;Awareness;Biomedical Research;college;Communication;Competence;Decision Making;design;Development;E-learning;Education;education resources;Effectiveness;effectiveness outcome;Electronics;empowerment;Evaluation;Event;evidence base;flexibility;formative assessment;global health;Goals;Health;Healthcare;improved;Institution;Instruction;interdisciplinary approach;International;Iowa;Journals;Knowledge;Learning;learning materials;Learning Module;learning outcome;lectures;Manuscripts;Measures;Medical Education;Medicine;member;National Institute of General Medical Sciences;next generation;Outcome;Participant;Peer Review;pilot test;Play;Positioning Attribute;Program Effectiveness;Program Evaluation;programs;Publications;Publishing;Qualitative Methods;Research;Research Institute;Research Personnel;Research Training;Resources;Role;Scholars Program;Science;science education;skills;Societies;success;symposium;System;Teaching Hospitals;Teaching Materials;Teaching Method;Time;tool;Training;Training Programs;Universities;University Hospitals;Veterinary Medicine;web site

PROJECT_TITLE: Empowering Researchers through Evaluation: The Development of Online Educational Modules for Evaluating Biomedical Research Training Programs

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 TWD-U (RW)]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Contraception/Reproduction;Hematology;Pediatric;Prevention;Women's Health Research

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE Heavy menstrual bleeding is a frequent and life-altering problem for adolescents and young adults with heritable bleeding disorders, but this population has previously been excluded from research on treatments. In this multicenter prospective clinical trial of U.S. adolescents and young adults with heritable bleeding disorders, we aim to compare two commonly used treatments that are successful for menstrual suppression in those without heritable bleeding disorders – 52 mg levonorgestrel intrauterine device (LNG-IUD) and norethindrone acetate (NETA). Under this application we will compare the bleeding outcomes, satisfaction, hemostatic parameter changes, and patient reported quality of life measures at baseline and through 6 months of treatment and compare LNG-IUD treatment results to a control group without a bleeding disorder, with the goal of determining the benefits and expected outcomes of these treatment options for this population.

PI_NAMEs: BALDWIN, MAUREEN  (contact);WHEELER, ALLISON PAROSKIE

PROGRAM_OFFICER_NAME: CROTTI ESPINOZA, LUCIANA B

PROJECT_TERMS: Activities of Daily Living;Adolescent;Adolescent and Young Adult;Affect;Aftercare;Age;Anemia;Blood Coagulation Disorders;Blood Tests;Caring;Clinic;Clinical Trials;Control Groups;Counseling;Data;Diagnosis;Diagnostic;Diagnostic tests;disease diagnostic;effective therapy;Effectiveness;Enrollment;Evidence based practice;Exclusion;experience;Factor VIII-Related Antigen;Family;Ferritin;Goals;Health;health assessment;health related quality of life;Health Status;Hemorrhage;Hemostatic Agents;Heritability;Hormonal;Hospitalization;improved;Incidence;Information Systems;Interdisciplinary Study;Intrauterine Devices;Investigation;Iron;iron deficiency;Knowledge;Left;Levonorgestrel;Life;Measurement;Measures;member;Mental Health;Methods;multidisciplinary;Norethisterone Acetate;novel diagnostics;Oral;Outcome;Outcome Assessment;Participant;Patient Outcomes Assessments;Patient Self-Report;Patients;Persons;Pharmaceutical Preparations;physical conditioning;Physiological;Population;Pragmatic clinical trial;pragmatic trial;primary outcome;Progestin Therapy;Progestins;prospective;Prospective Studies;Provider;Quality of life;Questionnaires;Recommendation;Records;Reporting;Research;Research Personnel;Residual state;Retrospective Studies;Safety;satisfaction;Schools;Science;secondary outcome;Site;Specialist;Stress;success;Symptom Burden;Test Result;Testing;Therapeutic;tool;Transfusion;treatment comparison;Treatment outcome;von Willebrand Disease;von Willebrand Factor;Work;Youth

PROJECT_TITLE: Heavy Menstrual Bleeding Progestin Treatment in Bleeding Disorders Study

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-J (96)]


NIH_SPENDING_CATS: Cardiovascular;Congenital Heart Disease;Congenital Structural Anomalies;Genetics;Heart Disease;Pediatric;Rare Diseases

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Summary: We have identified a discrete stage of heart valve development that is critical for aortic valve morphogenesis and have also discovered a unique cascade of endocardial signaling proteins that are essential for normal valve formation prior to birth. Our goal is to understand how these signaling cascades within the endocardium direct normal aortic valve development. As most congenital heart defects involve abnormalities of heart valve formation, these studies will lay the foundation for understanding the etiology many congenital heart diseases.

PI_NAMEs: BALDWIN, H SCOTT (contact)

PROGRAM_OFFICER_NAME: EVANS, FRANK

PROJECT_TERMS: Affect;Agonist;Alleles;Anatomy;aortic valve;autocrine;bicuspid aortic valve;Birth;Candidate Disease Gene;Cardiac;Cell Nucleus;Cell Proliferation;Cells;Collaborations;conditional knockout;conditional mutant;Congenital Abnormality;congenital anomaly;congenital heart abnormality;Congenital Heart Defects;Critical Pathways;critical period;Cultured Cells;Cytoplasm;Data;Defect;Development;Disease;EGF-Like Domain;Embryo;Embryonic Heart;Endocardium;Endothelial Cells;Endothelium;Etiology;Event;Exclusion;Exposure to;Extracellular Matrix Proteins;Foundations;FOXO1A gene;Frequencies;gain of function;Goals;Growth;Harvest;Heart Abnormalities;Heart failure;Heart Valve Diseases;Heart Valves;Histologic;Human;Immunoglobulins;in vivo;inducible Cre;kinase inhibitor;Knock-out;Knockout Mice;Life;LoxP-flanked allele;MAP Kinase Gene;MAPK3 gene;Mediating;Mesenchymal;Mesenchyme;Mitral Valve;Modeling;Morphogenesis;Mus;mutant;Mutant Strains Mice;Nuclear;overexpression;paracrine;Pathology;Pathway interactions;Phenocopy;Phenotype;Phosphorylation;PIK3CG gene;Play;Process;protein expression;Protein Tyrosine Kinase;Proto-Oncogene Proteins c-akt;Regulation;Role;semilunar valve;Signal Pathway;Signal Transduction;Signaling Protein;single-cell RNA sequencing;Tamoxifen;TEK gene;Testing;Thinness;Time;transcription factor;transcriptome sequencing;Tricuspid valve structure;Variant;versican;Work

PROJECT_TITLE: The role of Tie2 signaling in Aortic Valve Remodeling

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CDD-Q (81)]


NIH_SPENDING_CATS: Aging;Assistive Technology;Behavioral and Social Science;Bioengineering;Bipolar Disorder;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Neurosciences;Rehabilitation;Serious Mental Illness

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: Bipolar disorder, an often-debilitating condition associated with a high risk for suicide, is characterized by dramatic and recurrent shifts in mood, energy levels and behavior ranging from the lows of depression (lasting weeks or months) to the highs of mania (lasting at least a week). There is an urgent need for more effective treatments of the depressive phase of bipolar disorder; accordingly, this study will test whether deep brain stimulation (DBS), a neurosurgical procedure widely using in movement disorders, is effective and safe in 10 patients with bipolar depression. To reduce the risk of inducing mania, emerging signs such as decreased need for sleep, increased activity, rapid speech, and elevated mood, will be monitored using a variety of mobile monitoring methods (e.g., wearables, smart phone readouts, audio diaries, etc.) together with recording of brain activity by the DBS device.

PI_NAMEs: GOODMAN, WAYNE K (contact);HERRON, JEFFREY A.;PROVENZA, NICOLE RENEE;SHETH, SAMEER ANIL

PROGRAM_OFFICER_NAME: FRANKOWSKI, MEGAN MICHELLE

PROJECT_TERMS: Acute;Affect;Affective;Algorithms;Anxiety;Apple watch;Behavior;behavior measurement;Behavioral;Bipolar Depression;Bipolar Disorder;Blinded;Brain;capsule;Cellular Phone;Chronic;Clinic;Clinical;clinical risk;Clinical Trials;clinically relevant;Cluster Analysis;cohort;Computer software;Computer Vision Systems;Coupled;Custom;dashboard;Data;Deep Brain Stimulation;density;Depressed mood;depressive symptoms;Detection;Development;Devices;diaries;effective intervention;effective therapy;Effectiveness;efficacy outcomes;Enrollment;Environment;Ethics;Feasibility Studies;feature detection;Feedback;follow-up;Force of Gravity;Functional Magnetic Resonance Imaging;Funding;Future;Goals;Heart Rate;high risk;Home;Home environment;Hour;hypomania;Individual;Intervention;Label;Life;longitudinal course;Machine Learning;Magnetoencephalography;Manic;Measurement;Measures;meetings;Mental Depression;Mental disorders;Methods;Monitor;Moods;Morbidity - disease rate;mortality;Movement Disorders;multimodality;neural;neural correlate;neurobehavioral;neurodevelopment;neuropsychiatric disorder;Neurosurgical Procedures;Notification;novel;open label;Outcome;Outcome Measure;Participant;Pathologic;patient biomarkers;patient population;Patient Self-Report;Patients;Phase;Physiological;Predictive Value;Prior Therapy;Recurrence;recurrent depression;Research;Resistance;Resolution;response;Rest;Rewards;Risk;Risk Reduction;Safety;Services;Short-Term Memory;Sleep;Speech;Standardization;suicidal risk;System;Techniques;Testing;Time;Trust;United States National Institutes of Health;Update;Ventral Striatum;Voice;wearable device;Work

PROJECT_TITLE: Building Mood State Classifiers to Inform Deep Brain Stimulation (DBS) of Treatment-Resistant Bipolar Depression

STUDY_SECTION: NSD

STUDY_SECTION_NAME: Neurological Sciences and Disorders C Study Section[NSD-C]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: KANSAS CITY

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: PROJECT NARRATIVE African Americans experience among the highest levels of tobacco-related disease and socioeconomic disadvantage; approximately 85% of African Americans who smoke use menthol, which contributes to persistent tobacco use. This study will characterize unmet social needs of African American menthol users by assessing community- and individual-level disadvantage, and will subsequently examine these key factors in relation to smoking treatment outcomes, with the goal of identifying opportunities to address needs and enhance treatment. Improving treatment for African Americans, including menthol users, is central to reducing disease burden and enhancing health equity.

PI_NAMEs: COX, LISA SANDERSON (contact)

PROGRAM_OFFICER_NAME: CICCOLO, JOSEPH THOMAS

PROJECT_TERMS: Abstinence;Address;Adult;Advertising;African American;African American population;Award;biopsychosocial;Black race;Bupropion;burden of illness;care outcomes;Censuses;Child Care;Cigarette;Clinical Trials;Clothing;Communities;Cotinine;Counseling;Data;Disadvantaged;Disease;Disparity;Education;Enrollment;Evaluation;Evidence based intervention;experience;Food;Funding;Goals;health care quality;health disparity;health disparity populations;health equity;Healthcare;Home;Housing;housing instability;improved;indexing;Individual;Industry;Infrastructure;innovation;Institutional Racism;Insurance;Intervention;Link;long term abstinence;Low income;Measures;medication compliance;Menthol;Modeling;Morbidity - disease rate;mortality;neighborhood disadvantage;Neighborhoods;Outcome;Ownership;Parents;Participant;Patient Self-Report;people of color;Pharmacotherapy;Population;Poverty;Prediction of Response to Therapy;Process;Protocols documentation;Randomized;Reporting;Resolution;Risk;Sampling;Services;Smoke;Smoker;Smoking;smoking abstinence;smoking cessation;smoking prevalence;Smoking treatment;social;social determinants;social disparities;social vulnerability;Social Work;socioeconomic disadvantage;standard care;structural health determinants;System;Telephone;Tobacco;Tobacco use;Transportation;Treatment Efficacy;Treatment outcome;treatment trial;Vulnerable Populations;Work

PROJECT_TITLE: Improving smoking cessation outcomes in the African American community through extended treatment: Addressing social vulnerability to advance treatment of menthol users

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CCHI-X (57)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Lewy Body Dementia;Neurodegenerative;Neurosciences;Parkinson's Disease

ORG_CITY: Los Angeles

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

ORG_STATE: CA

PHR: NARRATIVE Up to 80% of the 8.5 million people diagnosed with Parkinson’s disease (PD) worldwide will develop dementia within a decade of diagnosis, yet we know little about what processes are occurring in the brain in those who develop PDD versus those who do not, and what clinical and neuroimaging measures best predict PDD. Overcoming the small samples and low power of prior studies, we launch a global initiative with unprecedented power to understand what leads to dementia in PD - what are the primary risk factors, and which kinds of neuroimaging data are most valuable to collect, and for which patients.

PI_NAMEs: JAHANSHAD, NEDA ;THOMPSON, PAUL M (contact)

PROGRAM_OFFICER_NAME: BABCOCK, DEBRA J

PROJECT_TERMS: Address;Adult;Age;age effect;age related;Aging;Atlases;Basal Ganglia;biobank;Biological Markers;Brain;Brain Mapping;Brain region;brain tract;Caregiver Burden;Clinical;Clinical Data;clinical practice;cognitive impairment in Parkinson's;Country;Data;Data Collection;Data Pooling;Data Set;Deep Brain Stimulation;Dementia;Deterioration;Diagnosis;Diffusion Magnetic Resonance Imaging;Disease;Disease Progression;disorder subtype;Economic Burden;Female;Fiber;Future;Image;Impaired cognition;Individual;innovation;International;Knowledge;Length;Life;Life Expectancy;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;male;Maps;Measures;Methods;mild cognitive impairment;Modeling;Morbidity - disease rate;mortality;Neuroanatomy;neuroimaging;North America;novel;Odds Ratio;Parietal Lobe;Parkinson Disease;Parkinson's Dementia;Participant;Pathology;Pathway interactions;Patients;Pattern;personalized medicine;Persons;Population;Process;Prognostic Marker;prognostic value;Research;Risk Factors;Sample Size;Sampling;Scanning;sex;Site;Specificity;statistics;stem;Structural defect;Structure;Subgroup;symptom treatment;Temporal Lobe;Testing;Therapeutic;treatment planning;Vascular Diseases;white matter;White Matter Hyperintensity;Work

PROJECT_TITLE: Worldwide Tractometry Initiative to Investigate Brain Microstructure, Cognitive Impairment & Dementia in Parkinsons Disease

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


ADMINISTERING_IC: OH

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH

ORG_CITY: COOPERSTOWN

ORG_NAME: MARY IMOGENE BASSETT HOSPITAL

PHR: NARRATIVE: OVERALL CENTER AgFF industries have the highest rates of occupational fatality in the country and AgFF workers suffer from disproportionately high rates of work-related illness and injury, as well as chronic health conditions, suicide and stress. This application seeks to improve the health and welfare of AgFF populations in the Northeast by working collaboratively with AgFF partners, industries and workers to develop solutions that are effective and can be easily adopted by the workforce.

PI_NAMEs: SORENSEN, JULIE ANN (contact)

PROJECT_TITLE: Northeast Center for Occupational Health and Safety: Agriculture, Forestry and Fishing


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Digestive Diseases;Digestive Diseases - (Gallbladder);Liver Disease;Microbiome;Rare Diseases

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE Biliary tract inflammation contributes to the development and progression of many common human biliary and liver pathologies, but our understanding of immune processes within the biliary tract is exceedingly limited. I have characterized resident immune cell populations in the extrahepatic biliary tree at high resolution, and found that the make-up of this biliary immune niche is impacted by biliary epithelial cells and the microbiome-status of the host. This project will test how the microbiome, microbial metabolites, and biliary epithelial cells impact the biliary immune niche, and will test whether alterations in the biliary immune niche at homeostasis, specifically the presence or absence of neutrophils, impacts the progression of cholesterol gallstone disease.

PI_NAMEs: O'LEARY, CLAIRE E (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Acute;Adult;Biliary;Biliary Atresia;biliary tract;Biliary Tract Cancer;Biliary Tract Diseases;Biology;career development;Cell Shape;cell type;Cells;Childhood;Cholangiocarcinoma;Cholecystitis;Cholelithiasis;Cholesterol;Chronic;Clinical;Collaborations;Data;Dendritic Cells;design;Development;Development Plans;Diet;Disease;Disease Progression;Environmental Risk Factor;Epithelial Cells;Epithelium;Event;Extrahepatic;Extrahepatic Bile Ducts;Frequencies;Gallbladder;gallstone disease;Germ-Free;granulocyte;Health;Homeostasis;Hospitalization;host microbiome;Human;Immune;immune cell infiltrate;Immune system;Immunologics;Immunology;immunoregulation;Infiltration;Inflammation;Inflammatory;Inflammatory Response;Integration Host Factors;Left;Ligands;Link;Liver;Liver Failure;liver transplantation;Lymphocyte;Lymphoid Cell;Macrophage;Malignant Neoplasms;Methods;microbial;microbiome;microbiota;mortality;Mucous Membrane;Mus;neutrophil;Neutrophil Infiltration;Normal tissue morphology;Operative Surgical Procedures;Pathologic;Pathology;Phenotype;Play;Population;post-doctoral training;primary sclerosing cholangitis;Process;Property;receptor;Recording of previous events;repository;Reproducibility;Research;Resolution;Risk;Risk Factors;Role;Secretory Cell;Sensory;Severities;Severity of illness;Shapes;Signal Transduction;single cell sequencing;single-cell RNA sequencing;Stromal Cells;Surface;Testing;Therapeutic Intervention;therapeutic target;Tissue atlas;Tissues;Training;Volatile Fatty Acids;Work

PROJECT_TITLE: Modulation of the biliary immune niche by the microbiome

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases B Research Study Section[MID-B]


ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

PHR: Project Narrative Multiple system atrophy (MSA) is a rare, rapidly progressive, and invariably fatal neurological condition characterized by autonomic failure, parkinsonism, and/or ataxia. There is no available treatment to slow or halt disease progression. Based on strong efficacy signals from a recently completed early phase study, we propose a randomized double-blind, placebo-controlled, phase II trial to assess optimal dosing frequency, efficacy and safety of adipose-derived autologous mesenchymal stem cells delivered into the spinal fluid of patients with MSA.

PI_NAMEs: SINGER, WOLFGANG  (contact)

PROGRAM_OFFICER_NAME: POKROVNICHKA, ANJELINA

PROJECT_TITLE: Randomized Double-Blind Placebo-Controlled Adaptive Design Trial of Intrathecally Administered Autologous Mesenchymal Stem Cells in Multiple System Atrophy


ORG_CITY: RALEIGH

ORG_NAME: NORTH CAROLINA STATE UNIVERSITY RALEIGH

PHR: PROJECT NARRATIVE Biostatisticians are key contributors to cardiovascular disease research, and demand continues to escalate for PhD biostatisticians with the required training, particularly in this era of biomedical big data. This program will provide predoctoral students at North Carolina State University and Duke University with unique training that integrates rigorous study of statistical theory and methods with a collaborative apprenticeship working on cutting edge cardiovascular disease research studies in multidisciplinary teams at the Duke Clinical Research Institute to prepare them to make immediate contributions to the cardiovascular disease research enterprise.

PI_NAMEs: O'BRIEN, SEAN M;STAICU, ANA-MARIA  (contact)

PROGRAM_OFFICER_NAME: COADY, SEAN

PROJECT_TERMS: Biometry;Research;Training

PROJECT_TITLE: Integrated Biostatistical Training for CVD Research

STUDY_SECTION: NITM

STUDY_SECTION_NAME: NHLBI Institutional Training Mechanism Study Section[NITM(JA)]


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

ORG_CITY: BOSTON

ORG_NAME: TUFTS UNIVERSITY BOSTON

PHR: Project Narrative We propose to train the next generation of clinical and translational researchers to meet the nation's health care challenges of the coming decades. We will provide training in the core knowledge expectations of clinical and translational science (CTS) to clinical and biomedical research postdoctoral fellows in the Tufts CTS Graduate Program and prepare them to be effective leaders, team members, communicators, and innovators in CTS. In addition to a general CTS track, we offer three specialized tracks: Predictive Analytics and Comparative Effectiveness Research (PACER), One Health, and Health Policy and Health Disparities (HPHD).

PI_NAMEs: KENT, DAVID M (contact)

PROGRAM_OFFICER_NAME: CONROY, JENNIE LYNN

PROJECT_TERMS: Postdoctoral Fellow;Universities

PROJECT_TITLE: CTSA Postdoctoral T32 at Tufts University


ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

PHR: PROJECT NARRATIVE The Cell and Molecular Biology program at Duke University is an interdisciplinary training program that allows graduate students to explore the rich and diverse landscape of biomedical research before committing to an area of focus. Through required and elective coursework, rigorous thesis research and diverse professional development resources, students are prepared for a range of careers that contribute to fundamental scientific knowledge and promote human health.

PI_NAMEs: BOYCE, MICHAEL S (contact);DI TALIA, STEFANO

PROGRAM_OFFICER_NAME: HARTON, MARIE DEBORAHGAYNELLE

PROJECT_TERMS: Cellular biology;Molecular Biology;Training Programs

PROJECT_TITLE: Cell and Molecular Biology Training Program

STUDY_SECTION_NAME: Training and Workforce Development Study Section - A[TWD-A]


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE This project will generate the most robust evidence to guide administrators about whether and how to prioritize continuity of care in ICUs to improve quality and minimize costs. We will use econometric methods (causal statistical methods), qualitative methods and optimization and simulation modeling to determine the quality and economic case for improving continuity of ICU interprofessional teams. The results will have direct impact on informing organizational approaches to human resource allocation in intensive care units in Michigan, Massachusetts and ultimately, nationally.

PI_NAMEs: YAKUSHEVA, OLGA  (contact)

PROGRAM_OFFICER_NAME: SIMPSON, MATTHEW

PROJECT_TITLE: A quality and cost analysis of interprofessional team continuity in ICUs

STUDY_SECTION: HEOR

STUDY_SECTION_NAME: Healthcare Effectiveness and Outcomes Research[HEOR]


ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative This program trains students to address challenges in human health by applying the foundations of biology to life at a chemical and molecular level. The program brings together chemists, biologists, engineers, and physician-scientists to foster creative thinking across disciplinary lines, leading to the discovery and engineering of molecules, materials and measurement tools that advance human health. Students trained in this program will be primed to revolutionize the way medicines and medical treatments are conceived, created, and implemented.

PI_NAMEs: BERTOZZI, CAROLYN  (contact)

PROJECT_TITLE: Stanford ChEM-H Chemistry/Biology Interface Predoctoral Training Program

STUDY_SECTION_NAME: Training and Workforce Development Study Section - B[TWD-B]


NIH_SPENDING_CATS: Aging;Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Child Abuse and Neglect Research;Childhood Injury;Clinical Research;Genetics;Human Genome;Mental Health;Mental Illness;Pediatric;Physical Injury - Accidents and Adverse Effects;Post-Traumatic Stress Disorder (PTSD);Prevention;Social Determinants of Health;Violence Research;Youth Violence

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

ORG_STATE: PA

PHR: Project Narrative Child maltreatment is a significant cause of morbidity and mortality in the U.S. Better understanding of proximate mental and physical health predictors after childhood traumatic stressful events (TSEs), including genetic susceptibility and early biologic embedding by epigenetic age acceleration (EAA) and increased inflammation, may facilitate targeted interventions to ameliorate the long-term health burden. Using the Philadelphia Neurodevelopmental Cohort (PNC) and Center for Applied Genomics (CAG) pediatric biorepositories at The Children’s Hospital of Philadelphia, this project will test the hypothesis that childhood TSEs are associated with a spectrum of mental and physical health consequences that are influenced by genetic susceptibility and biologic embedding.

PI_NAMEs: CHAIYACHATI, BARBARA HIRSCHMAN (contact)

PROGRAM_OFFICER_NAME: BECHTHOLT, ANITA JEAN

PROJECT_TERMS: Abate;accelerated epigenetic aging;Accounting;Address;Adolescence;Adult;Age;Attention;Award;Behavioral;biobank;Biological;career;Child;Child Abuse;Child Abuse and Neglect;Child Health;Child Welfare;Childhood;childhood adversity;Clinical;clinical care;Clinical Immunology;cohort;comorbidity;Complex;cytokine;Data;Development;developmental psychology;Diagnosis;Diagnostic;Dimensions;DNA Methylation;Dose;early life adversity;Emotional;Environment;Epigenetic age;epigenetic aging;epigenetic clock;Epigenetic Process;epigenomics;experience;Funding;Future;gene environment interaction;Genes;Genetic;Genetic Predisposition to Disease;Genetic Risk;Genomic approach;genomic data;Genomics;Goals;Grant;Gur;Health;IL6 gene;Immunology;improved;Inflammation;Inflammatory;innovation;insight;Intervention;K-Series Research Career Programs;Leadership;longitudinal, prospective study;maltreatment;Measurable;Measures;Medical;Mental Health;Mentorship;Methylation;methylome;Modernization;Morbidity - disease rate;mortality;multimodality;Neurology;neuropsychiatry;Outcome;Paper;Pediatric Hospitals;Pediatric Research;pediatric trauma;Pediatrics;Pennsylvania;phenomics;Phenotype;Philadelphia;physical abuse;physical conditioning;Physicians;pleiotropism;Policies;polygenic risk score;Population Heterogeneity;Positioning Attribute;Post-Traumatic Stress Disorders;Predisposition;professor;Psyche structure;Psychiatry;psychogenetics;Psychopathology;Radiology Specialty;Reporting;Research;Research Personnel;Risk;Role;Sampling;Scientist;sex;Sex Differences;Sexual abuse;skills;Stress;Stressful Event;Supervision;systemic inflammatory response;Testing;Training;training opportunity;translational genomics;Translational Research;Trauma;trauma exposure;Universities;whole genome;Work;Writing

PROJECT_TITLE: Clinical and biologic health trajectories after early life adversity

STUDY_SECTION: BGES

STUDY_SECTION_NAME: Behavioral Genetics and Epidemiology Study Section[BGES]


NIH_SPENDING_CATS: Genetics;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative The completion of this proposal will lead to a better understanding of ubiquitin-based regulation of emergency hematopoiesis in the bone marrow. Defining the molecular mechanism that links ubiquitin signaling pathway with protein degradation and gene expression, and establishing the importance of such regulation in the response of hematopoietic stem cells to inflammation, will be critical for generating effective personalized therapeutic approaches.

PI_NAMEs: AIFANTIS, IANNIS ;BUSINO, LUCA  (contact)

PROGRAM_OFFICER_NAME: QASBA, PANKAJ

PROJECT_TERMS: Acute;Amino Acid Motifs;Animal Model;Applications Grants;Area;Automobile Driving;Binding;Biochemical;Bone Marrow;Bortezomib;Cell Communication;Cell Compartmentation;cell injury;Cells;Chemicals;Chromatin;chronic inflammatory disease;Clinical;Complex;conditional knockout;Cytokine Receptors;Data;Diagnostic;Emergency Situation;epigenomics;Gene Expression;Gene Expression Regulation;Genetic Transcription;Glues;healing;Hematological Disease;Hematopoiesis;Hematopoietic;Hematopoietic stem cells;Hematopoietic System;hematopoietic tissue;Homeostasis;IL1R1 gene;Immune response;Immune system;In Vitro;in vivo;Inflammation;Inflammatory;Inflammatory Response;Injury;interest;Intervention;IRAK2 gene;irradiation;Knowledge;Ligase;Link;Malignant Neoplasms;Maps;Mediating;Modeling;Molecular;Molecular Conformation;multicatalytic endopeptidase complex;Multiprotein Complexes;mutant;Mutant Strains Mice;MyD88 protein;Myelogenous;Names;Neutrophilia;NF-kappa B;novel;novel therapeutic intervention;Organism;Output;pathogen;Pathology;Pathway interactions;personalized therapeutic;Phenotype;Phosphotransferases;Poison;Post-Translational Regulation;Process;programs;Proliferating;Proteasome Inhibitor;protein degradation;Proteomics;recruit;Regulation;Research;Resolution;response;restoration;restraint;Role;role model;Signal Pathway;Signal Transduction;stem cells;Stimulus;stoichiometry;Structure;success;Syndrome;System;Systemic infection;systemic inflammatory response;Therapeutic;Therapeutic Intervention;tissue injury;Tissues;Toll-like receptors;transcription factor;Transcriptional Regulation;transcriptomics;Transducers;Ubiquitin;ubiquitin-protein ligase;Ubiquitination;Viral

PROJECT_TITLE: Regulation of emergency hematopoiesis by the ubiquitin-proteasome system

STUDY_SECTION: HTBT

STUDY_SECTION_NAME: Hemostasis, Thrombosis, Blood Cells and Transfusion Study Section[HTBT]


ORG_CITY: NEW YORK

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: Project Narrative This program in pulmonary and critical care medicine provides comprehensive research training for individuals with a firm commitment to a career in research focused on lung disease. Our major goal is to train future physician scientists and scientists to become independent researchers in academic medicine. This T32 program will enable trainees to have a better understanding of the pathogenesis of lung disease and to identify new diagnostic or therapeutic modalities in these disorders.

PI_NAMEs: KANER, ROBERT J;STOUT DELGADO, HEATHER WINONA (contact)

PROGRAM_OFFICER_NAME: ESPINOZA-PINTUCCI, MARISOL

PROJECT_TITLE: Multidisciplinary Approach Training in Respiratory Research

STUDY_SECTION_NAME: NHLBI Institutional Training Mechanism Study Section[NITM(OA)]