NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Prevention;Substance Misuse

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: PROJECT NARRATIVE The goal of the HIV Prevention Trials Network (HPTN) is to identify safe, effective, implementable, and scalable interventions for HIV prevention. The HPTN Laboratory Center (LC) will provide leadership, expertise, and laboratory support to the HPTN and oversee all laboratory activities in HPTN studies. The HPTN LC will participate in all phases of science generation; oversee and support activities at study sites; perform testing for HPTN protocols; develop, evaluate, and validate new laboratory methods; and perform innovative laboratory- based research related to HIV prevention.

PI_NAMEs: ESHLEMAN, SUSAN H (contact);MARZINKE, MARK A

PROGRAM_OFFICER_NAME: DEJLI, JAMAL

PROJECT_TERMS: Address;Adolescent;Africa;AIDS prevention;Ancillary Study;Anti-Retroviral Agents;Area;Asia;assay development;Award;Behavior Therapy;Behavioral;Biological Assay;Biomedical Research;Clinical;Clinical Trials;Clinical Trials Network;co-infection;cohort;Cohort Studies;Collaborations;Communities;Couples;Data;design;Development;Discipline;Drug Delivery Systems;Eastern Europe;Ensure;Epidemic;Evaluation;experience;Generations;Goals;Government;HIV;HIV prevention trial;HIV prevention trials network;HIV/AIDS;Human immunodeficiency virus test;Immunology;Individual;industry partner;Infrastructure;Injecting drug user;innovation;insight;Institution;International;Intervention;Investigational New Drug Application;Laboratories;laboratory equipment;laboratory experiment;Laboratory Procedures;Laboratory Scientists;Latin America;Lead;Leadership;Medical;meetings;men who have sex with men;Mentors;Methods;Mission;neutralizing antibody;novel;novel therapeutics;Observational Study;operation;Participant;Passive Immunization;Pathogenesis;Pathologist;Performance;Persons;Pharmaceutical Preparations;Pharmacology;Phase;Play;point of care testing;Population Heterogeneity;Populations at Risk;Positioning Attribute;pre-exposure prophylaxis;Prevention Research;Prevention strategy;product development;protocol development;Protocols documentation;Psychological Transfer;quality assurance;Quality Control;Regulatory Affairs;remote technology;Research;research and development;research clinical testing;Research Personnel;response;Risk;Role;Science;Shapes;Site;Social Behavior;Specialist;study population;System;Technology;Technology Transfer;Toxicology;transgender women;transmission process;trial enrollment;United States;United States Food and Drug Administration;vaccination strategy;Validation;virology;Woman;Work;working group

PROJECT_TITLE: LC: HIV PREVENTION TRIALS NETWORK


ADMINISTERING_IC: GM

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: SAN FRANCISCO

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE Receptor tyrosine kinases (RTKs) constitute second largest family of membrane receptors in human genome that transduce the bulk of the signals that control cellular growth, proliferation and survival. Their activation by extracellular growth factors sets in motion a series of poorly understood conformational changes which transduce signals across the plasma membrane. By aiming to solve first high resolution full-length structures of human epidermal growth factor receptor tyrosine kinases (EGFR/HERs), we aim to provide critical information about the mechanism of RTK signal transduction, ultimately aiming to enable the development of new strategies to combat aberrant signaling by these receptor complexes in cancer and other human diseases.

PI_NAMEs: JURA, NATALIA  (contact)

PROGRAM_OFFICER_NAME: LEWIS, MECHELLE MAYLEBEN

PROJECT_TERMS: Affect;Biological;cell growth;Cell membrane;Cells;combat;combinatorial;Complex;Coupled;Cryoelectron Microscopy;Data Set;Development;dimer;Dimerization;Disease;Elements;Epidermal Growth Factor Receptor;ERBB2 gene;ERBB3 gene;ErbB4 gene;extracellular;Extracellular Domain;Family;Future;Goals;Growth Factor;Human;human disease;Human Genome;innovation;Knowledge;Length;Ligand Binding;Ligands;Malignant Neoplasms;Measurement;member;Membrane;Modeling;Molecular;Molecular Conformation;Motion;Mutation;Negative Staining;Outcome;Phosphorylation;Phosphotransferases;Process;Proliferating;Proteins;receptor;Receptor Protein-Tyrosine Kinases;Receptor Signaling;Recombinants;Resolution;response;Role;Sampling;Series;Side;Signal Transduction;Structure;System;Testing;therapeutic target;Transmembrane Domain;Work;X-Ray Crystallography

PROJECT_TITLE: Structural and Functional Studies of HER Receptors

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Dental, Oral, and Craniofacial Disease;Immunotherapy;Orphan Drug;Precision Medicine;Rare Diseases

ORG_CITY: LA JOLLA

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: NARRATIVE There is an urgent need to develop new therapeutic options to treat head and neck squamous cell carcinomas (HNSCC). Targeting the immune checkpoint PD-1 has revolutionized HNSCC treatment. However, the overall response rate of anti-PD-1 therapies remains low (15-20%). Our overall objective is to increase the response to anti-PD-1 treatment by targeting oncogenic signaling circuitries, and to exploit the emerging information of the HNSCC genomic mutational landscape and the single cell understanding of the anti-tumor immune response to inform the molecular stratification for patient selection in future precision immune oncology trials.

PI_NAMEs: GUTKIND, JORGE SILVIO  (contact)

PROGRAM_OFFICER_NAME: VENKATACHALAM, SUNDARESAN

PROJECT_TERMS: anti-cancer;anti-PD1 therapy;anti-tumor immune response;Bar Codes;Biological Models;cancer cell;Cancer Remission;candidate validation;Cells;Cessation of life;chromatin immunoprecipitation;Clinical;Clinical Trials;Cytometry;Development;Disabling;Disease remission;DNA Sequence Alteration;ERBB3 gene;Exhibits;FRAP1 gene;Future;Genetic;Genetic Engineering;genome editing;Genomics;Grant;Head and Neck Squamous Cell Carcinoma;Human;Immune;immune checkpoint;immune checkpoint blockade;Immune Evasion;Immune response;Immune Targeting;Immunooncology;Immunotherapy;improved;In complete remission;Laboratories;Lesion;Ligands;Malignant Neoplasms;Modeling;Molecular;Monoclonal Antibodies;Morbidity - disease rate;mortality;mTOR inhibition;mTOR Signaling Pathway;multimodality;Mus;Mutation;Nivolumab;novel;novel therapeutics;Oncogenes;Oncogenic;oncology trial;Pathway interactions;patient derived xenograft model;Patient Selection;patient stratification;Patients;PD-1 blockade;pembrolizumab;personalized immunotherapy;Pharmacodynamics;Phase II Clinical Trials;PIK3CA gene;PIK3CG gene;Population;Precision therapeutics;predictive signature;Predictive Value;Prognosis;programmed cell death protein 1;Resistance;Resolution;response;restraint;RNA interference screen;Signal Transduction;single-cell RNA sequencing;System;targeted agent;targeted treatment;Therapeutic;Tobacco;transcriptomics;Treatment Efficacy;Treatment Protocols;tumor;tumor growth;Tumor Suppressor Genes;tumor xenograft;tumor-immune system interactions;Tyrosine Phosphorylation;United States

PROJECT_TITLE: Co-targeting the HER3 oncogenic signaling circuitry and PD-1 as a novel multimodal precision immunotherapy for HNSCC

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-H(02)M]


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Cancer Genomics;Genetics;Human Genome;Women's Health Research

ORG_CITY: HOUSTON

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: PROJECT NARRATIVE Chemoresistance is a major clinical problem in breast cancer patients with triple-negative disease, in which over half of the patients develop resistance and frequently progress to metastatic disease and death. The proposed studies will use single cell sequencing technologies to investigate the genomic and phenotypic evolution of tumor cells and the tumor microenvironment during the progression of chemoresistance and metastatic disease. Our studies are directly aligned with the mission of the NIH to decrease morbidity and improve the quality of life for breast cancer patients, by discovering new fundamental knowledge on chemoresistance in TNBC patients and identifying novel therapeutic targets and biomarkers that will benefit patient care.

PI_NAMEs: NAVIN, NICHOLAS  (contact)

PROGRAM_OFFICER_NAME: DEY, SUMANA MUKHERJEE

PROJECT_TERMS: Address;Adjuvant Chemotherapy;Aftercare;Biopsy;Breast Cancer Patient;Breast Cancer Treatment;Cell Line;Cell Reprogramming;cell type;Cells;Cessation of life;Chemoresistance;chemotherapy;Classification;Clinic;Clinical;clinical application;cohort;CRISPR/Cas technology;Data;Data Set;Diagnosis;diagnostic biomarker;diagnostic technologies;Disease;Disease Resistance;Distant;DNA;DNA sequencing;Ecology;Evolution;Gene Expression;Gene Expression Profile;Genes;genetic signature;Genetic Transcription;Genomics;Genotype;Goals;Grant;Heterogeneity;Hormonal;Human;improved;In Vitro;Inherited;knock-down;Knowledge;Left;Malignant Breast Neoplasm;Methods;Mission;Modeling;Morbidity - disease rate;Mutation;Neoadjuvant Therapy;Neoplasm Metastasis;neoplastic cell;new therapeutic target;novel diagnostics;Organ;Outcome;overexpression;Patient Care;Patients;Phenotype;Primary Neoplasm;programs;Quality of life;receptor;Refractory Disease;Resistance;Resistance development;response;RNA;Role;Sampling;Signal Pathway;single cell genomics;single cell sequencing;single cell technology;single-cell RNA sequencing;Site;Stromal Cells;targeted treatment;Technology;The Cancer Genome Atlas;Therapeutic;therapeutic biomarker;therapeutic target;Therapy trial;Time;Tissue Sample;transcriptional reprogramming;transcriptome sequencing;transcriptomics;Translating;treatment response;triple-negative invasive breast carcinoma;tumor;tumor microenvironment;United States National Institutes of Health

PROJECT_TITLE: DELINEATING THE EVOLUTION AND ECOLOGY OF CHEMORESISTANCE IN BREAST CANCER WITH SINGLE CELL GENOMICS

STUDY_SECTION: CG

STUDY_SECTION_NAME: Cancer Genetics Study Section[CG]


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding

ORG_CITY: CHAMPAIGN

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

ORG_STATE: IL

PHR: The proposed Summer Undergraduate Research Program in Toxicology (SURE Tox) will provide undergraduate students who are underrepresented minorities with high quality research experiences during the summer academic break. Students will receive extensive research training in the field of environmental health/toxicology, participate in a number of workshops on research ethics, use of animals in research, academic and industry careers in toxicology, how to apply to graduate school, how to write and present scientific papers, and optional Graduate Record Exam workshops.

PI_NAMEs: FLAWS, JODI A. (contact);NOWAK, ROMANA A.

PROGRAM_OFFICER_NAME: HUMBLE, MICHAEL C

PROJECT_TERMS: Animals;career;college;Complement;Digital Libraries;Educational workshop;Enrollment;Environmental Health;experience;Faculty;faculty mentor;Funding;Goals;graduate school;Illinois;Industry;Laboratories;Learning;Medical Students;meetings;member;minority student;Paper;Participant;posters;programs;Research;Research Ethics;Research Training;responsible research conduct;Scholars Program;skills;student training;Students;summer research;symposium;Techniques;Toxicology;Training;Training Programs;undergraduate research experience;undergraduate student;Underrepresented Minority;Universities;Work;Writing

PROJECT_TITLE: Summer Undergraduate Research Experience in Toxicology


ADMINISTERING_IC: DC

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences

ORG_CITY: BALTIMORE

ORG_DEPT: PSYCHOLOGY

ORG_STATE: MD

PHR: Project Narrative Our work hopes to identify general circuit rules and dynamics that enable neuroplasticity and we argue that behaviorally-relevant plasticity is not only about the acquisition of knowledge but also the ability to use that knowledge in the appropriate behavioral context. Diseases such as post-traumatic stress disorder (PTSD), language disorders, and autism may hijack these parallel learning mechanisms in distinct ways to drive pathology. This proposal provides essential data on basic auditory learning mechanisms that will enable a fundamental neurobiological basis to explore a myriad of neurological disorders.

PI_NAMEs: KUCHIBHOTLA, KISHORE V (contact)

PROGRAM_OFFICER_NAME: POREMBA, AMY

PROJECT_TERMS: Acoustics;Animals;Association Learning;Auditory;Auditory area;auditory stimulus;Auditory system;autism spectrum disorder;Axon;basal forebrain;Behavior;Behavioral;Behavioral Paradigm;behavioral response;Brain;Calcium;Cells;cholinergic;Code;Color;Complement;Data;Development;Discrimination;Discrimination Learning;Disease;Dissociation;Educational process of instructing;excitatory neuron;Exhibits;experience;flexibility;Image;Impairment;improved;in vivo;Knowledge;Knowledge acquisition;Laboratories;Language Disorders;Learning;Link;Measures;Mediating;Modeling;Monitor;Mus;Music;Nervous System Disorder;neural;neural circuit;Neurobiology;neuromechanism;Neuronal Plasticity;Neurons;neuroregulation;optogenetics;Pathology;Patients;Pattern;Phase;Post-Traumatic Stress Disorders;Process;Psychological reinforcement;Publishing;receptive field;response;Rewards;Role;Sensory;Shapes;Signal Induction;Signal Transduction;Site;sound;spatiotemporal;Speech;Stereotyping;Stimulus;Symptoms;Synapses;System;Testing;Time;Training;two-photon;voltage clamp;Water;Whole-Cell Recordings;Work

PROJECT_TITLE: Neural circuits for flexible audiomotor learning

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Genetics;Physical Injury - Accidents and Adverse Effects

ORG_CITY: PHILADELPHIA

ORG_DEPT: ORTHOPEDICS

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative Tendon injuries are challenging clinical problems due to slow, incomplete healing with fibrovascular scar formation. The limited understanding of the regulatory mechanisms underlying fibrovascular scar formation is a significant gap in knowledge, hindering the development of effective treatment modalities for tendon diseases. This proposal aims to define the function of the mTORC1/Stat3 signaling cascade in fibrovascular scar formation and evaluate the beneficial effects of mTORC1/Stat3 modulation on regenerative tendon healing.

PI_NAMEs: JOENG, KYU SANG  (contact)

PROGRAM_OFFICER_NAME: PINTUCCI, GIUSEPPE

PROJECT_TERMS: 3-Dimensional;Adhesions;Area;Biological;biomechanical test;cancer cell;Cells;Cellularity;Chronic;Cicatrix;Clinical;Clinical Research;clinically significant;Complex;Data;Development;Disease;effective therapy;experimental study;Extracellular Matrix;Fibroblasts;Flexor;FRAP1 gene;gain of function;Gene Expression;Genetic;Genetic Models;Genetic study;Genetic Transcription;Goals;healing;Human;Image;in vivo;Infiltration;Injury;innovation;interdisciplinary approach;Knowledge;loss of function;Mediating;Mediator;Modality;Modeling;Molecular;Molecular Analysis;mouse genetics;mouse model;Mus;neovascularization;novel;Operative Surgical Procedures;Outcome;Pain;patellar tendon;Pathogenicity;pharmacologic;Pharmacology Study;Phenotype;postnatal;Qualifying;regenerative;Regenerative Medicine;Regulation;Reporting;Research;rotator cuff tear;Signal Transduction;STAT1 protein;Stat3 protein;success;Surgical Injuries;Targeted Research;Tendinopathy;tendon development;Tendon Injuries;tendon rupture;Tendon structure;Testing;therapeutic target;Tissues;Transcriptional Regulation;translational approach;Translational Research;wound

PROJECT_TITLE: The function of mTORC1/Stat3 signaling in the regulation of fibrovascular scar formation during tendon healing

STUDY_SECTION: SBSR

STUDY_SECTION_NAME: Skeletal Biology Structure and Regeneration Study Section[SBSR]


ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

ORG_STATE: NY

PHR: PROJECT NARRATIVE The overarching goal of the proposed research is to explore the metabolism of T cells in order to develop metabolic imaging approaches with hyperpolarized (HP) MR. It has been shown that T-cell therapies are hindered by a dearth of metabolic precursors in the tumor microenvironment. In this work, we aim to better understand T-cell metabolism using novel tools and models and to develop strategies to overcome metabolic limitations. We aim to enhance the glycolytic metabolism of T cells by giving them a unique endogenous substrate for their metabolism, fructose, which is present in our diet but not normally metabolized by a wide range of cancers. This work will advance the treatment of a range of solid tumors and develop non-invasive metabolic biomarkers for cancer immunotherapy.

PI_NAMEs: KESHARI, KAYVAN R (contact)

PROGRAM_OFFICER_NAME: LIU, YIN

PROJECT_TERMS: Address;Animal Model;Biochemistry;Biological Availability;Biological Models;Cancer Biology;cancer biomarkers;cancer cell;cancer immunotherapy;Carbon;Cell Physiology;Cellular Metabolic Process;Charge;checkpoint inhibition;chimeric antigen receptor T cells;Clinic;Data;Diet;Dietary Component;Effectiveness;effector T cell;Energy Metabolism;engineered T cells;Engineering;Enzymes;Exclusion;exhaust;exhaustion;Exhibits;extracellular;Foundations;Fructose;fructose-1-phosphate;Future;Gluconeogenesis;Glucose;Glucose Transporter;GLUT-2 protein;Glycolysis;Goals;Image;imaging approach;immune checkpoint blockade;Immune checkpoint inhibitor;Immune system;Immunotherapeutic agent;Immunotherapy;In Vitro;in vivo;in vivo Model;innovation;Insulin;Investigation;Isotopes;Ketohexokinase;Kidney;liquid chromatography mass spectrometry;Liver;Magnetic Resonance;Magnetic Resonance Imaging;magnetic resonance spectroscopic imaging;Malignant Neoplasms;Measures;Mediating;Melanoma;Metabolic;metabolic imaging;Metabolism;metabolomics;Methods;Modeling;Monosaccharides;Motivation;Mus;neoplastic cell;new technology;non-invasive imaging;novel;novel strategies;Nutrient;overexpression;Oxygen;Pathway interactions;Patients;Production;Proliferating;Research;response;Serine;Small Intestines;Solid Neoplasm;sugar;System;T cell therapy;T-Cell Activation;T-Lymphocyte;Technology;Time;Tissues;Titrations;tool;trafficking;Translating;Translations;tumor;tumor microenvironment;Warburg Effect;Work

PROJECT_TITLE: Leveraging fructose transport to create a privileged substrate to selectively fuel T cells

STUDY_SECTION: IPCA

STUDY_SECTION_NAME: Imaging Probes and Contrast Agents Study Section[IPCA]


PHR: Project Narrative The goal of this project is to engineer therapeutic immune cells that are substantially safer and more effective in treating solid tumors.

PI_NAMEs: LIM, WENDELL A (contact)

PROGRAM_OFFICER_NAME: ZAMISCH, MONICA

PROJECT_TERMS: Antigen Presentation;Antigens;B lymphoid malignancy;cancer cell;candidate identification;cell killing;Cell Therapy;cell type;Cells;chimeric antigen receptor;chimeric antigen receptor T cells;combinatorial;Complex;cross reactivity;Cytotoxic T-Lymphocytes;design;Ecosystem;efficacy evaluation;Endothelial Cells;engineered T cells;Engineering;Epithelium;Fibroblasts;Goals;Growth;Immune;Immunotherapeutic agent;improved;In Vitro;Individual;Malignant - descriptor;Malignant neoplasm of lung;Malignant neoplasm of ovary;Malignant Neoplasms;mesothelin;Molecular;mouse model;neoplastic cell;Normal tissue morphology;Organ;pancreatic cancer model;Play;Pre-Clinical Model;receptor;Role;Signal Transduction;Solid;Solid Neoplasm;Source;spatial integration;Specificity;Stromal Cells;Stromal Neoplasm;success;Supporting Cell;Surface Antigens;T cell therapy;T-Lymphocyte;Testing;Therapeutic;Therapeutic Agents;Tissues;tool;Toxic effect;tumor;Tumor Antigens;tumor microenvironment;tumor xenograft;VTCN1 gene;Work;Xenograft Model

PROJECT_TITLE: Recognizing the tumor ecosystem: Integrating stromal and cancer antigen signals to achieve precision recognition of solid tumors by CAR T cells

STUDY_SECTION: CII

STUDY_SECTION_NAME: Cancer Immunopathology and Immunotherapy Study Section[CII]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: Columbus

ORG_DEPT: PHYSIOLOGY

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE Mitophagy plays an essential role in preserving cardiovascular homeostasis by identifying and selectively eliminating dysfunctional mitochondria. This project aims to delineate novel molecular mechanisms connecting mitophagy to myocardial substrate utilization, and to assess the physiological implications when mitophagy is specifically altered. These studies will lead to a greater understanding of how myocardial energy metabolism is linked to mitochondrial quality control, and provide groundwork for the development of novel therapeutic approaches in the treatment of heart disease.

PI_NAMEs: SUN, NUO  (contact)

PROGRAM_OFFICER_NAME: WONG, RENEE P

PROJECT_TERMS: Adult;Affect;Attenuated;Bioenergetics;Cardiac;Cardiac Myocytes;Cardiomyopathies;cardioprotection;Cardiovascular Physiology;Cardiovascular system;carnitine palmitoyltransferase 2 deficiency;Carnitine Palmitoyltransferase I;Deubiquitinating Enzyme;Deubiquitination;Development;Energy Metabolism;Exhibits;Fatty Acids;functional decline;gain of function;Genes;Genetic;genetic analysis;Glucose;Goals;Heart;Heart Diseases;Heart failure;heart function;Heart Hypertrophy;Homeostasis;Human;human induced pluripotent stem cells;Impairment;improved;In Vitro;in vivo;in vivo monitoring;induced pluripotent stem cell;inhibitor;Inner mitochondrial membrane;innovation;insight;Intervention;Kinetics;Knock-out;Knowledge;Link;long chain fatty acid;Lysosomes;Mediating;Metabolic;Metabolism;Mitochondria;mitochondrial dysfunction;Mitochondrial Membrane Protein;mitochondrial metabolism;Modeling;Molecular;mouse model;Mus;Myocardial;novel;novel therapeutic intervention;Nuclear;Outer Mitochondrial Membrane;oxidation;Parkin;Pathologic;Pathway interactions;Peptide Hydrolases;pharmacologic;Phenotype;Phosphotransferases;Physiological;PINK1 gene;Play;premature;presenilin;preservation;pressure;Production;programs;Proteins;PTEN gene;Quality Control;Reaction;Reagent;receptor;Regulation;Research;Research Proposals;response;rhomboid;Role;Signal Pathway;spatiotemporal;Stress;Testing;Therapeutic;therapeutic target;Tissues;treatment strategy;Ubiquitin;ubiquitin isopeptidase;ubiquitin-protein ligase;Ubiquitination

PROJECT_TITLE: Interplay between mitophagy and substrate utilization in heart failure progression

STUDY_SECTION: MPPB

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology B Study Section[MPPB]


NIH_SPENDING_CATS: Cancer

ORG_CITY: SYRACUSE

ORG_DEPT: UROLOGY

ORG_NAME: UPSTATE MEDICAL UNIVERSITY

PHR: PROJECT NARRATIVE Cell invasion through the basement membrane barrier is one of the early phases in the multistep process of tumor cell dissemination and indicative of disease progression. The proposed research is relevant to public health because elucidation of regulatory mechanisms of cell invasion will ultimately increase our understanding of diseases that depend on this behavior to progress. Thus, the proposed research is relevant to NIH's mission because it will yield fundamental knowledge that will assist in the improvement of human health and translate into new treatments for invasive diseases including neurodegenerative, cardiovascular and cancer.

PI_NAMEs: BOURBOULIA, DIMITRA  (contact)

PROGRAM_OFFICER_NAME: PHILLIPS, ANDRE W

PROJECT_TERMS: 2-tyrosine;Affect;Affinity;analog;angiogenesis;ATP Hydrolysis;ATP phosphohydrolase;Basement membrane;Behavior;Binding;Biochemical;Biological Assay;Biophysics;Calorimetry;Cardiovascular system;Cell Culture Techniques;Cell Line;Cell membrane;cell motility;Cell Physiology;Cells;chaperone machinery;Client;Clustered Regularly Interspaced Short Palindromic Repeats;Communicable Diseases;Complex;design;Disease;Disease Progression;Drug Targeting;Ensure;Enzyme Kinetics;extracellular;Extracellular Matrix;Extracellular Space;Genetic;Goals;Health;Heat-Shock Proteins 90;Homeostasis;HSP 90 inhibition;Human;Human Cell Line;Hydrolysis;Hyperactivity;improved;In Vitro;in vivo;Individual;inhibitor;innovation;insight;Invaded;Knock-out;Knowledge;Laboratories;Malignant Neoplasms;Matrix Metalloproteinase Inhibitor;Measures;Mediating;Metalloproteases;mimetics;Mission;MMP2 gene;Molecular Chaperones;mutant;N Domain;Neoplasm Metastasis;neoplastic cell;Nerve Degeneration;Neurodegenerative Disorders;Outcome;Pathway interactions;Peptide Hydrolases;Pharmaceutical Preparations;pharmacologic;Phase;prevent;Process;protein protein interaction;protein-tyrosine kinase c-src;Proteins;Proteolysis;Public Health;Publishing;Regulation;Regulatory Element;Reporting;Research;response;Role;Signal Transduction;Small Interfering RNA;System;targeted treatment;Technology;Testing;Therapeutic;therapeutic target;Tissue Inhibitor of Metalloproteinases;Translating;Tumor Cell Invasion;Tumor-Associated Process;Tyrosine Phosphorylation;United States National Institutes of Health;Work;wound healing

PROJECT_TITLE: Regulation of the extracellular HSP90 chaperone machinery

STUDY_SECTION: MBPP

STUDY_SECTION_NAME: Membrane Biology and Protein Processing Study Section[MBPP]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PROJECT NARRATIVE In developed countries allergic diseases effect up to 1/5th of the population and in developing countries 2 billion people worldwide are infected with parasitic worms; these two diseases seem very much unrelated, however, both involve the human IgE antibody response. As industrialized countries eliminate parasitic worms the incidence of allergic diseases, particularly those to foods, has steadily risen – resulting in an “allergy epidemic”. Studying human IgE at the molecular level as monoclonal antibodies will allow for the most basic and critical interactions to be assessed between the human IgE antibody and the allergen proteins of peanut and will provide new insights into the often pathological but potentially protective aspect of the human adaptive immune system.

PI_NAMEs: SMITH, SCOTT ALAN (contact)

PROGRAM_OFFICER_NAME: DONG, GANG

PROJECT_TERMS: Adaptive Immune System;Affinity;Albumins;Allergens;Allergic;Allergic Disease;Allergy to peanuts;Anaphylaxis;Antibodies;Antibody Response;Antigenic Specificity;associated symptom;B-Lymphocytes;Basophils;Binding;Biological Assay;Cells;Cellular Assay;Circulation;Clinical;Clinical Data;clinical predictors;clinically relevant;Clone Cells;Complex;cross reactivity;crosslink;design;Developed Countries;Developing Countries;Development;Diagnostic;Disease;Dose;Enzyme-Linked Immunosorbent Assay;Epidemic;Epitopes;Exposure to;Food;Freezing;Generations;Goals;Helminths;Human;Hybridomas;Hypersensitivity;IgE;Immunoglobulin G;Immunotherapy;In Vitro;in vivo;Incidence;Individual;insight;Knowledge;Location;Maps;mast cell;Measures;Mediating;Mediator;Methods;Molecular;Monoclonal Antibodies;novel;passive sensitization;Pathogenesis;Pathologic;Patients;peripheral blood;Persons;Play;Population;preservation;Process;Proteins;prototype;receptor;Recombinants;Research Subject Selections;Research Subjects;Resolution;response;Role;Serum;Severities;Severity of illness;Site;Specificity;Structure;Therapeutic;Time;Tissues;tool;Transgenic Mice;Vaccines;Variant;Work;X-Ray Crystallography

PROJECT_TITLE: Comprehensive antigenic mapping of the human anti-peanut IgE antibody response

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IMM-T(57)S]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Autoimmune Disease;Behavioral and Social Science;Brain Disorders;Multiple Sclerosis;Neurodegenerative;Neurosciences

ORG_CITY: Aurora

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative The link between behaviorally-relevant neuronal activity and circuit-specific changes in myelination remains unknown. Our proposal incorporates an innovative and cross-disciplinary approach to dissect how behavior shapes the pattern of myelination on the level of individual axons in defined circuits during learning and myelin repair.

PI_NAMEs: HUGHES, ETHAN GARRETT (contact)

PROGRAM_OFFICER_NAME: UTZ, URSULA

PROJECT_TERMS: Address;Adult;Affect;Axon;Behavior;Behavior Therapy;Behavioral;Biology;Brain;Central Nervous System Diseases;Communities;Data;Demyelinations;disability;Disease;efficacy testing;Etiology;Forelimb;Frequencies;Goals;Health;in vivo;Individual;Inflammatory;Injury;innovation;insight;Knowledge;Learning;Length;Lesion;Life Experience;Link;Memory;Motor;motor behavior;Motor Cortex;motor disorder;motor learning;motor recovery;motor rehabilitation;Motor Skills;mouse model;Multiple Sclerosis;multiple sclerosis patient;Mus;Myelin;Myelin Sheath;myelination;neural;neural circuit;neuronal circuitry;Neurons;novel;novel strategies;novel therapeutics;Oligodendroglia;Pattern;Persons;Process;Recovery;remyelination;repaired;response;Role;Seizures;Shapes;skill acquisition;skills training;Specificity;Techniques;therapeutic candidate;Therapeutic Intervention;Time;Visualization

PROJECT_TITLE: Precision of Myelin Plasticity in Health and Disease

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Brain Disorders;Neurosciences;Stimulant Use and Misuse

ORG_CITY: Nashville

ORG_NAME: VANDERBILT UNIVERSITY

PHR: PROJECT NARRATIVE  3,4-methylenedioxymethamphetamine (MDMA) is abused by millions of Americans every year, resulting in addiction due to increases in synaptic levels of serotonin through its mechanism at the serotonin transporter (SERT). While under normal physiological conditions, SERT regulates synaptic concentrations of serotonin through reuptake (forward transport), MDMA alters SERT’s mechanism to engage in reverse transport. By illuminating structural motifs and dynamics associated with both SERT’s forward and reverse transport mechanisms, this research will provide foundational knowledge for combating MDMA addiction.

PI_NAMEs: SCHWARTZ, ALEXANDRA CORINNE (contact)

PROGRAM_OFFICER_NAME: UMANAH, GEORGE KWABENA ESSIEN

PROJECT_TERMS: 3-Dimensional;abuse liability;addiction;American;Amphetamine Addiction;Amphetamines;autism spectrum disorder;Benchmarking;Biochemical;Brain;Cell membrane;Cells;Chloride Ion;Collaborations;computer studies;conformational conversion;Coupled;Cryoelectron Microscopy;Crystallography;Data;data acquisition;Data Analyses;Dimensions;Disease;Dopamine;dopamine transporter;Drosophila melanogaster;drug action;Drug Design;drug of abuse;ecstasy;Electron Spin Resonance Spectroscopy;Electrons;Elements;Engineering;Equilibrium;experimental study;Fingerprint;Functional disorder;Future;Goals;Homologous Gene;Human;in vivo;insight;Ion Cotransport;Knowledge;Label;Laboratories;Length;Ligands;Light;Link;Lipid Binding;Lipids;Mediating;member;Membrane;Mental Depression;Mental disorders;Mentorship;Methodology;Modeling;Molecular;Molecular Conformation;Mutation;N-terminal;Neurons;neuropsychiatric disorder;neurotransmitter transport;Neurotransmitters;Norepinephrine;novel therapeutics;Phosphatidylinositol 4,5-Diphosphate;Physiological;Post-Translational Protein Processing;presynaptic;Presynaptic Terminals;protein expression;protein protein interaction;protein purification;Proteins;Research;Resolution;reuptake;Role;Sampling;Serotonin;serotonin transporter;Signal Transduction;Site;skills;Sodium;sodium ion;Solvents;Spectrum Analysis;Spin Labels;Stimulant;Structure;success;Surveys;symporter;Synapses;targeted treatment;Testing;therapeutic development;tool;Transmembrane Domain

PROJECT_TITLE: Structural Dynamics of the Human Serotonin Transporter


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: SAN DIEGO

ORG_NAME: VA SAN DIEGO HEALTHCARE SYSTEM

PHR: Heart diseases and in particular, heart failure are an increasing serious health concern in the Veteran population in particular, as the population ages and are exposed to risk factors such as post-traumatic stress disorder. Heart failure with preserved ejection fraction is more commonly seen in women and the VA has identified Women’s Veterans health as an area of priority research. Nearly 70% of male veterans are older than 55 years of age and the majority of female veterans are over 45 years of age (National Center for Veterans Analysis and Statistics report 2011). The current proposal aims to address the role of uncontrolled inflammation in the development of cardiac fibrosis in female animal models of heart failure with preserved ejection fraction where the heart fails to accommodate greater blood pumping volumes. The work described in this proposal will also test novel therapeutic strategies that may be effective in the future treatment of this disease.

PI_NAMEs: VILLARREAL, FRANCISCO J (contact)

PROJECT_TERMS: Address;Adverse event;Age;Age Years;aged;Agonist;Animal Model;Animals;Area;Attenuated;Blood;blood pump;Cardiac;Cardiac Output;Cells;Clip;Collagen;Complex;coronary fibrosis;cytokine;Data;Deposition;Development;Diffuse;Disease;drinking water;EFRAC;Endocardium;Exhibits;experience;Exposure to;Female;Fibroblasts;Fibrosis;fMet-Leu-Phe receptor;Fructose;Functional disorder;Future;Goals;Health;Heart;Heart Diseases;Heart failure;Hospitalization;Hypertension;improved;improved outcome;Inflammation;Inflammatory;Injury to Kidney;insight;interest;Kidney;Kidney Diseases;Lead;Left;Left Ventricular Remodeling;Left ventricular structure;Leucocytic infiltrate;Lipoxins;Macrophage;male;Mediator;Medicare;men;military veteran;Modeling;Mus;Myocardial;Myocardial Infarction;Myocardium;new therapeutic target;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutic intervention;Obesity;Oral Administration;Ovariectomy;Pathway interactions;Patients;pharmacologic;Phase I Clinical Trials;Phenotype;Physiological;Play;polarized cell;Population;Post-Traumatic Stress Disorders;Postmenopause;pre-clinical;preservation;prevent;Process;Property;Rattus;receptor;Relaxation;Reporting;Research;Research Priority;Resolution;Risk Factors;Rodent Model;Role;Severities;statistics;Steroids;Stress;systemic inflammatory response;Testing;Therapeutic;Tissues;tool;Ventricular;Veterans;Weight Gain;Woman;Work

PROJECT_TITLE: Beneficial Effects of FPR Agonists on an Animal Model of Early Stage Heart Failure with Preserved Ejection Fraction


FUNDING_MECHANISM: OTHERS

PHR: Sleep disruption is increasingly common in modern society. Many factors can compromise a good night's sleep, including medical reasons (obstructive sleep apnea, lower back pain), mental health issues (PTSD, depression), and societal factors (shift work, childcare, financial stress, etc.). One well-recognized aspect of health impacted by sleep is immune function as short sleepers typically have more infections and weaker immune responses to vaccines. In particular, veterans commonly report insomnia, poor sleep, and daytime sleepiness; specifically veterans with chronic sleep disruption are at higher risk of chronic inflammatory diseases. While addressing sleep is the most sensible approach, improving or restoring proper sleep is practically challenging. This study aims to explore how the immune system "senses" adequate sleep. By garnering a thorough understanding of these mechanisms, we can strategize ways to not only improve immune function but also slow down perpetual inflammatory insults due to sleep disruption.

PI_NAMEs: LAM, MICHAEL TUN YIN (contact)

PROJECT_TERMS: Activities of Daily Living;Acute;Address;adequate sleep;adverse outcome;Affect;Animals;ATAC-seq;Automobile Driving;Binding;Bone Marrow;Caring;Cells;Child Care;ChIP-seq;Chromatin;Chronic;chronic inflammatory disease;Clinical;clinical practice;Complex;Coupled;Critical Care;Critical Illness;cytokine release syndrome;Data;Disease;DNA Sequence;Drowsiness;Endotoxins;Enhancers;Enzymes;Exhibits;experience;experimental study;extracellular;Financial Hardship;Foundations;Gene Expression;Generations;Genes;Genetic Transcription;genome-wide;genome-wide analysis;genomic tools;Genomics;Global Change;Goals;Health;high risk;Homeostasis;Immune;immune function;Immune system;Immune System Diseases;immunoregulation;Immunosuppression;improved;Infection;infection risk;Inflammation;Inflammatory;Inflammatory Response;Innate Immune System;innovation;insight;Kinetics;Life;Link;Low Back Pain;Mediating;Medical;Medicine;Mental Depression;Mental Health;military veteran;mimetics;Modeling;Modernization;Molecular;mortality;mouse model;Mus;neutrophil;Neutrophil Activation;new therapeutic target;novel;novel therapeutic intervention;Obstructive Sleep Apnea;Outcome;pathogen;Pathway interactions;Patients;Peritoneal;Peritonitis;Peroxidases;Phagocytosis;pharmacologic;Phenotype;Physicians;poor sleep;Population;Post-Traumatic Stress Disorders;preservation;Procedures;Production;programs;Reactive Oxygen Species;Recovery;Regulatory Element;Reporting;Research;Risk;Role;Sepsis;septic;Septic Shock;shift work;Shock;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Sleep;Sleep Deprivation;Sleep Disorders;Sleep disturbances;Sleep Fragmentations;sleep regulation;Sleeplessness;Societal Factors;Societies;Techniques;Testing;Time;tool;transcription factor;Transcriptional Regulation;transcriptome;transcriptome sequencing;transcriptomics;Translating;translational potential;vaccine immunogenicity;Veterans

PROJECT_TITLE: The Role of Sleep in Innate Immune Homeostasis: Toward Mechanistic Understanding Through Genome-Wide Enhancer Analysis


ORG_CITY: CHARLESTON

ORG_NAME: RALPH H JOHNSON VA MEDICAL CENTER

ORG_STATE: SC

PHR: Chronic heart failure (CHF) has a designated Quality Enhancement Research Initiative (QUERI) in the VA system to address ways to improve cardiovascular healthcare for Veteran’s suffering from CHF. Success in treatment of CHF particularly CHF associated with chronic pressure overload (hypertension, aortic valve stenosis) is limited by the presence of persistent interstitial fibrosis despite our ability to normalize hemodynamic load. The proposed studies will define abnormalities in cellular and molecular mechanisms that cause this persistent fibrosis. If we can more completely define these mechanisms, then more effective and comprehensive patient care programs can be developed to limit the development and progression of HF, and reverse the abnormalities in heart structure and function. These issues are especially important in our Veterans who develop chronic heart failure at a younger age, have a high incidence of myocardial fibrosis, and have a disproportionately greater level of functional limitations.

PI_NAMEs: BRADSHAW, AMY D (contact);ZILE, MICHAEL R

PROJECT_TERMS: Ablation;Address;Age;Animal Model;aorta constriction;Aortic Valve Stenosis;Cardiac;cardiovascular health;Characteristics;Chronic;Clinical;clinically relevant;Collagen;Congestive Heart Failure;coronary fibrosis;Data;Deposition;Development;disease diagnosis;Disease Pathway;Excision;Exhibits;Exposure to;Extracellular Matrix;Fibroblasts;Fibrosis;Healthcare;Heart;hemodynamics;Homeostasis;Hypertension;Imaging Techniques;improved;In Vitro;in vivo;Incidence;innovation;interstitial;Lead;Macrophage;Matrix Metalloproteinases;Measurement;Measures;Mediating;Methods;Modification;Molecular;mouse model;Mus;Myocardial;Myocardium;novel;Outcome;Patient Care;Patients;Peptide Hydrolases;Phenotype;Physiological;Population;pressure;Production;profibrotic fibroblast;programs;Proteins;Publishing;Reproducibility;Research;response;Role;Structure;success;System;Testing;Time;Tissue Inhibitor of Metalloproteinase-1;Transgenic Mice;Veterans

PROJECT_TITLE: Cellular Mechanisms of Cardiac ECM Structure and Function


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Neurosciences;Schizophrenia;Serious Mental Illness;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PHR: Project Narrative This project will investigate brain bioenergetic alterations in schizophrenia using a translational approach that includes brain imaging, cognition, functioning, and clinical assessments in living patients, bioenergetics studies in cultured human iPSC-derived neurons/astrocytes, and biochemical confirmation studies in postmortem brain accompanied with bioinformatics. This project will help identify treatment targets in bioenergetic pathways that may improve cognition and quality of life in those with this devastating illness.

PI_NAMEs: MARANO, CHRISTOPHER  (contact);MCCULLUMSMITH, ROBERT E;WEN, ZHEXING

PROGRAM_OFFICER_NAME: MEINECKE, DOUGLAS L

PROJECT_TERMS: Affect;Age;Animal Model;Anterior;Antipsychotic Agents;Astrocytes;Autopsy;Biochemical;Bioenergetics;Bioinformatics;Biological;Biological Assay;Blood;Brain;brain dysfunction;Brain imaging;Brain region;Caring;Cell Line;cell type;Cells;cingulate cortex;Clinical;Clinical assessments;Coculture Techniques;Cognition;Cognitive;cognitive function;cost;Coupled;Data;Defect;Delusions;Development;Dopamine Antagonists;Dopamine D2 Receptor;Energy Metabolism;Enzymes;Failure;Functional disorder;functional outcomes;Generations;Genetic;Glucose;glucose uptake;Goals;Hallucinations;Human;Image;Impaired cognition;Impairment;improved;in silico;induced pluripotent stem cell;Induced pluripotent stem cell derived human neuron;Induced pluripotent stem cell derived neurons;Intervention;Lasers;Magnetic Resonance Spectroscopy;Medical;Metabolic;Metabolism;Methods;Microdissection;Molecular;Neurobehavioral Manifestations;neuroimaging;neuron development;Neuronal Plasticity;Neurons;novel therapeutic intervention;Occipital lobe;Outcome Assessment;Oxidative Phosphorylation;Pathologic;Pathway interactions;Patients;Persons;Pharmaceutical Preparations;Pharmacological Treatment;Population;Production;Protons;Quality of life;Reporting;Sampling;Schizophrenia;severe mental illness;sex;Symptoms;Thalamic structure;therapy development;tissue culture;Tissues;translational approach;uptake;Wages;Work

PROJECT_TITLE: Translational assessment of brain bioenergetic function in schizophrenia


NIH_SPENDING_CATS: Cancer;Genetics;Lung;Lung Cancer;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: STONY BROOK

ORG_DEPT: PATHOLOGY

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

PHR: PROJECT NARRATIVE Hexavalent chromium [Cr(VI)] is one of the most common environmental and occupational pollutants and exposure to Cr(VI) is a major environmental health concern, affecting millions of people in the United States as well many other countries. The goal of this study is to study the mechanism of Cr(VI) exposure causing cancer focusing on the role of functional RNA modification dysregulation.

PI_NAMEs: YANG, CHENGFENG  (contact)

PROGRAM_OFFICER_NAME: TYSON, FREDERICK L

PROJECT_TERMS: Affect;Biological Assay;Biological Process;Biology;Cancer Etiology;cancer stem cell;cancer therapy;carcinogenesis;carcinogenicity;Carcinogens;cell transformation;Cells;Chemicals;chromium hexavalent ion;Chronic;CISH gene;conditional knockout;Control Groups;Country;Data;DNA;Down-Regulation;environmental carcinogenesis;Environmental Carcinogens;Environmental Health;Enzyme-Linked Immunosorbent Assay;Exposure to;Gene Expression;Goals;Histones;Human;Impairment;Incidence;insight;Janus kinase;knock-down;Knockout Mice;Lung;Lung Neoplasms;lung tumorigenesis;Lysine;Malignant neoplasm of lung;Mediating;Messenger RNA;Metal Carcinogenesis;Methyltransferase;Microarray Analysis;Modification;Monoubiquitination;mouse model;Mus;novel;Nucleotides;Occupational;Oncogenic;overexpression;Pathway interactions;Persons;Play;pollutant;Post-Translational Protein Processing;Process;promoter;Promoter Regions;Property;Proteins;Reader;recruit;Resistance;Review Literature;Ribose;RNA;RNA Polymerase II;RNA Stability;Role;Small Interfering RNA;STAT protein;stem cell self renewal;stemness;transcriptome sequencing;Tumor Burden;tumor progression;Tumor Tissue;tumorigenesis;Tumorigenicity;ubiquitin isopeptidase;ubiquitin-protein ligase;United States;Untranslated RNA;Up-Regulation;Western Blotting

PROJECT_TITLE: Dysregulations of functional RNA modifications and hexavalent chromium lungcarcinogenesis

STUDY_SECTION: SIEE

STUDY_SECTION_NAME: Systemic Injury by Environmental Exposure[SIEE]


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Patient Safety;Physical Activity;Prevention

ORG_CITY: AUSTIN

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

PHR: PROJECT NARRATIVE Individuals diagnosed with heart failure (HF) in the southern U.S. face significant disparities in hospitalization and mortality rates, but effective HF self-management behaviors can reduce their healthcare burden and suffering. We propose a randomized controlled trial of a sensor-controlled digital game intervention in 7 southern U.S. states, to improve HF individuals’ knowledge, skills, and motivation to engage in the important HF self-management behaviors of weight monitoring and physical activity. This project will generate insight and guidance regarding the use of digital gaming as an affordable, portable, scalable technology to improve HF self-management behaviors and potentially reduce the burden of HF.

PI_NAMEs: RADHAKRISHNAN, KAVITA  (contact)

PROGRAM_OFFICER_NAME: SCHOPFER, DAVID WESLEY

PROJECT_TERMS: Accelerometer;Active Learning;Address;Adherence;Adult;Age;age group;aged;Behavior;behavior change;Behavior Therapy;Behavioral;Behavioral Model;behavioral outcome;Biometry;Cardiac health;Cellular Phone;Chronic Disease;Clinical Trials;Cognitive;compliance behavior;Control Groups;cost;Data;Death Rate;design;Diabetes Mellitus;Diagnosis;digital;digital phenotyping;Disparity;Ecological momentary assessment;Education;Educational Materials;effective intervention;efficacy evaluation;Electronics;Equilibrium;evidence base;Face;Feasibility Studies;feasibility trial;Feedback;Foundations;functional status;Geographic Locations;Geography;Goals;group intervention;Habits;Health;health disparity;Health Promotion;healthcare burden;Heart;Heart failure;Home;hospital readmission;Hospitalization;hospitalization rates;impaired functional status;improved;Incentives;Individual;individual response;innovation;insight;Intervention;Knowledge;Knowledge Management;Life Style;Measures;Methods;Monitor;Moods;Morbidity - disease rate;mortality;Motivation;Oklahoma;older adult;Outcome;pandemic disease;Participant;Patient Compliance;patient engagement;Pattern;Pharmaceutical Preparations;Physical activity;Play;portability;Precision Health;Prevention;primary outcome;processing speed;prospective;Psychology;Quality of life;racial health disparity;Randomized;Randomized Controlled Clinical Trials;Randomized, Controlled Trials;Recommendation;recruit;Regimen;remote intervention;Resources;response;Rewards;Sampling;satisfaction;scale up;secondary outcome;Self Efficacy;Self Management;sensor;skills;social;Software Engineering;Standardization;Symptoms;Technology;technology intervention;Texas;Time;tool;Vulnerable Populations;Weight;Weight maintenance regimen;Writing

PROJECT_TITLE: Sensor-controlled digital game for heart failure self-management behavior adherence: A randomized controlled trial

STUDY_SECTION: BMHO

STUDY_SECTION_NAME: Biobehavioral Medicine and Health Outcomes Study Section[BMHO]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: American Indian or Alaska Native;Anxiety Disorders;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Neurosciences;Post-Traumatic Stress Disorder (PTSD);Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: TULSA

ORG_NAME: LAUREATE INSTITUTE FOR BRAIN RESEARCH

ORG_STATE: OK

PHR: PROJECT NARRATIVE American Indians (AIs) display high rates of mental health difficulties; however, evidence indicates that when accounting for socio-cultural and demographic risk factors AIs appear resilient to mental health concerns. Although specific factors associated with AI culture have been identified as protective, there is a lack of research aimed at understanding behavioral and neural underpinnings of these protective effects. The primary aim of this work is to establish (1) brain and behavior responses that characterize the cultural protective factors among AIs and (2) an experimental, cultural identification paradigm to serve as the basis for future culturally informed neuroscientific research and intervention/prevention efforts.

PI_NAMEs: WHITE, EVAN JAMES (contact)

PROGRAM_OFFICER_NAME: LAI, GABRIEL Y

PROJECT_TERMS: Accounting;Address;American Indian Population;American Indians;Amygdaloid structure;Anxiety Disorders;Behavioral;behavioral response;blood oxygenation level dependent response;Brain;Buffers;Characteristics;Clinical;clinically relevant;Cognitive;cognitive control;cognitive enhancement;community based participatory research;Corpus striatum structure;Data;Data Analytics;Dedications;Demographic Factors;Diagnosis;Discrimination;disease model;effective therapy;emotion regulation;emotional functioning;Environment;Ethnic Population;Event-Related Potentials;Evidence based intervention;Exhibits;experience;family structure;Feedback;Foundations;Functional Magnetic Resonance Imaging;functional magnetic resonance imaging/electroencephalography;Future;Goals;health disparity;Image;Individual;Inferior frontal gyrus;Intervention;Interview;Investigational Therapies;Link;Literature;Measures;Mental disorders;Mental Health;Mentors;Mentorship;Mood Disorders;multimodality;National Institute of General Medical Sciences;neural;neural circuit;Neurocognitive;neuroimaging;neuromechanism;neuropsychiatric disorder;Neuropsychology;Neurosciences;novel;Outcome;Outcome Measure;Participant;Patient Recruitments;Patient Self-Report;Performance;Personal Satisfaction;Phase;Play;Population;post-traumatic stress;Post-Traumatic Stress Disorders;precision medicine;Prefrontal Cortex;Prevention;primary outcome;Process;protective effect;protective factors;Psychopathology;Publishing;Randomized;recruit;Research;resilience;resilience factor;response;reward processing;Rewards;Risk;Risk Factors;Role;Sampling;secondary outcome;Self Efficacy;Signal Transduction;social culture;Social support;Statistical Methods;Stress;substance use;suicidal risk;Suicide;suicide rate;Symptoms;Training;Trauma;trauma exposure;Tribes;Work

PROJECT_TITLE: Neuroscientific Exploration of Cultural Protective Factors in American Indians


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Neurosciences

ORG_CITY: PITTSBURGH

ORG_NAME: CARNEGIE-MELLON UNIVERSITY

PHR: PROJECT NARRATIVE Auditory selective attention (i.e., the ability to focus in on important parts of the auditory signal) is a critical part of listening, but it is impaired in a wide range of populations, including individuals with ADHD, children with developmental language disorders, and veterans who have been exposed to blast noises. The goal of this project is to clarify the cognitive and neural mechanisms that support auditory selective attention. In doing so, we will establish missing links between the nonhuman animal and human literatures on attention, and we will pave the way for long-term advances in biomedical engineering (such as “smart” hearing aids).

PI_NAMEs: LUTHRA, SAHIL  (contact)

PROGRAM_OFFICER_NAME: SCHURMAN, JACLYN REBECCA

PROJECT_TITLE: Mechanisms of auditory selective attention for speech and non-speech stimuli


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Cardiovascular;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_CITY: BATON ROUGE

ORG_NAME: LOUISIANA STATE UNIV AGRICULTURAL CENTER

ORG_STATE: LA

PHR: Project Narrative  After myocardial infarction, the infarcted myocardium is replaced by a fibrotic scar, which is mediated by cardiac fibroblasts. The proposed research will explore the role of Runx1 in the myocardial infarction-induced proliferation and differentiation of cardiac fibroblasts, which will reveal novel therapeutic targets for treating heart failure. If the application is funded, this public health relevance statement will be combined with the project summary (above) and will become public information.

PI_NAMEs: FU, XING  (contact)

PROGRAM_OFFICER_NAME: SHI, YANG

PROJECT_TERMS: Acute;acute myeloid leukemia 1 protein;ATAC-seq;Biological Assay;bone marrow mesenchymal stem cell;Cardiac;Cardiac Myocytes;Cell Differentiation process;Cell Nucleus;Cell Proliferation Regulation;Cessation of life;Chondrocytes;Chondrogenesis;Cicatrix;Cleavage Under Targets and Release Using Nuclease;cofactor;Communication;coronary fibrosis;Coupled;DNA Polymerase II;Enhancers;Epidermal Growth Factor;Equilibrium;Extracellular Matrix;Fibroblasts;Fibrosis;Funding;Gene Expression;Genes;healing;Heart;Heart failure;heart function;Heart Injuries;Hi-C;In Vitro;Infarction;Injury;Knock-out;Knockout Mice;loss of function;Maintenance;Mass Spectrum Analysis;Mediating;Mitotic Activity;Molecular;Mus;Myocardial Infarction;Myocardial rupture;Myocardium;Myofibroblast;Natural regeneration;new therapeutic target;non-compliance;Phase;Play;Polymerase;premature;prevent;Process;Proliferating;promoter;Protein Family;Protein Isoforms;Proteins;public health relevance;Regulation;Reporting;Research;response;response to injury;RNA;Role;Signal Pathway;Signal Transduction;Stains;Tamoxifen;Techniques;Therapeutic;therapy development;Tissues;transcriptome sequencing;Transforming Growth Factor beta;treatment strategy;Up-Regulation;Wild Type Mouse;wound healing

PROJECT_TITLE: The function of Runx1 in cardiac fibroblasts and post-myocardial infarction healing


NIH_SPENDING_CATS: Cardiovascular;Heart Disease

PHR: RELEVANCE. Exosomes are potential means of intercellular communications and transmission of macromolecules between cells, and are projected for drug delivery as well as therapeutic targets for several diseases including cardioprotection. For the first time, we have discovered and recorded a functional channel from intact exosomes and showed their potential in cardioprotection. The results of this investigation will allow the advancement of cardioprotective medicine and provide new molecular targets in exosomes for therapeutics.

PI_NAMEs: KHAN, MAHMOOD ;SINGH, HARPREET  (contact)

PROJECT_TERMS: Animals;Attention;Biochemical;Biogenesis;Biological;biophysical properties;Body System;Brain Hypoxia-Ischemia;Calcium;Cardiac;Cardiac Myocytes;cardioprotection;Cell Death;Cell membrane;Cells;coronary fibrosis;Cytoplasm;Cytoprotection;Data;Data Analyses;delivery vehicle;Disease;Disease Marker;Distant;Docking;Drug Delivery Systems;Electrophysiology (science);Environment;exosome;experimental study;extracellular;extracellular vesicles;Face;Future;gain of function;Genetic;Goals;Heart;Homeostasis;Human;human induced pluripotent stem cells;imaging approach;in silico;induced pluripotent stem cell derived cardiomyocytes;innovation;intercellular communication;Investigation;Ion Channel;Ion Exchange;Ions;large-conductance calcium-activated potassium channels;Link;Liposomes;macromolecule;Measures;Mediator;Medicine;Membrane;Messenger RNA;Methods;MicroRNAs;Mitochondria;Molecular;Molecular Biology;molecular imaging;Molecular Target;mouse model;Mus;mutant;Myocardial Infarction;Myocardial Ischemia;Myocardial Reperfusion Injury;new technology;novel;Organelles;Osmolar Concentration;Osmosis;Osmotic Shocks;Outcome;patch clamp;Physiological;Physiology;Plasma;Play;Potassium;Potassium Channel;Process;programs;Proteins;Proteomics;Pump;Reperfusion Injury;Reporting;RNA Splicing;Role;sensor;Signal Transduction;Source;Stress;superresolution microscopy;targeted delivery;Techniques;Testing;Therapeutic;therapeutic development;therapeutic target;Time;Tissues;transmission process;Variant;Voltage-Gated Potassium Channel;Wild Type Mouse

PROJECT_TITLE: Molecular identity of exosomal BK channels

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-TDPS-R(01)]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Foodborne Illness;Genetics;Infectious Diseases

ORG_CITY: CLEMSON

ORG_NAME: CLEMSON UNIVERSITY

PHR: PROJECT NARRATIVE  Toxoplasma gondii infects almost one-third of the human population in the world, causing severe disease and even lethality in people with compromised immune systems. The regulation of physiology and function of the digestive vacuole in Toxoplasma parasites plays important roles in parasite infections. Our proposed studies aim to understand how parasites control efflux of small nutrient molecules from the digestive vacuole to maintain its morphology and function, which will establish a scientific basis of identifying new therapeutic targets to impact toxoplasmosis.

PI_NAMEs: DOU, ZHICHENG  (contact)

PROGRAM_OFFICER_NAME: MCGUGAN, GLEN C

PROJECT_TITLE: Regulation of the physiology and function of the digestive vacuole in Toxoplasma gondii

STUDY_SECTION: PTHE

STUDY_SECTION_NAME: Pathogenic Eukaryotes Study Section[PTHE]


NIH_SPENDING_CATS: Cancer;Genetics;Hematology

ORG_DEPT: BIOCHEMISTRY

PHR: Type II topoisomerases are ubiquitous enzymes that remove knots and tangles from the genetic material by passing an intact double helix through a transient double-stranded break that they generate in a separate DNA segment. These enzymes are targets for important anticancer drugs, but are also capable of triggering specific types of leukemias. To more fully understand these essential enzymes and develop more effective topoisomerase II-targeted anticancer drugs, we propose to further determine how type II enzymes function and how drugs alter their activities in vitro and in cultured cells.

PI_NAMEs: OSHEROFF, NEIL  (contact)

PROGRAM_OFFICER_NAME: SIMONOVIC, MILJAN

PROJECT_TERMS: Acute Promyelocytic Leukemia;Affect;anti-cancer;Antineoplastic Agents;Apoptosis;Bacillus anthracis;Biological;Catalysis;Catalytic DNA;Catenated DNA;CDC2 gene;Cell Death;cell growth;cell killing;Cell Proliferation;Cell Survival;Cells;Chemotherapy-Oncologic Procedure;Chromatids;Chromosomal translocation;Chromosome Segregation;Chromosome Structures;Complex;Cultured Cells;Cyclin B;Daughter;Development;DNA;DNA biosynthesis;DNA Damage;DNA Double Strand Break;DNA topoisomerase II alpha;DNA Topoisomerase IV;drug action;drug development;Drug Prescriptions;Drug Targeting;egg;environmental chemical;enzyme activity;Enzyme Inhibition;Enzymes;Escherichia coli;Etoposide;experimental study;Gene Mutation;Generations;Genetic Materials;Genetic Recombination;Genetic Transcription;genome integrity;Geometry;Handedness;Herb;Human;Human Activities;Impairment;In Vitro;in vitro activity;inhibitor;innovation;Learning;leukemia;Magnetism;Malignant Neoplasms;Mechanical Stress;Mediating;Medicine;Mitosis;Mitoxantrone;MLL gene;Multiple Sclerosis;Mycobacterium tuberculosis;Naphthoquinones;Natural Products;Neurofibrillary Tangles;neuron development;novel;novel therapeutics;Pathway interactions;Patients;Pharmaceutical Preparations;Physiological;Play;PML gene;Poison;pollutant;Property;Protein Isoforms;Reaction;Regulation;Relaxation;Research;Research Design;Role;single molecule;Specificity;Study models;targeted agent;Techniques;Time;Topoisomerase;Topoisomerase II;Topoisomerase Inhibitors;Toxin;Type I DNA Topoisomerases;Xenopus laevis

PROJECT_TITLE: Mechanistic Studies of Type II Topoisomerases and Topoisomerase-Targeted Agents

STUDY_SECTION: MGA

STUDY_SECTION_NAME: Molecular Genetics A Study Section[MGA]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Immunization;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Project Narrative The Johns Hopkins University-Blantyre, Malawi Clinical Trials Unit (CTU) and its Clinical Research Site (CRS) in Blantyre, Malawi have the expertise, experience, infrastructure and commitment to contribute to the scientific agendas of four NIAID Clinical Research Networks. Over the past 30 years, including 13 years in the preivious and current CTU cycle, the CRS has strong relationships with the community, in order to educate stakeholders about the value of research and to share key findings from all studies. The CTU Principal Investigator is strongly supported by the host institution, the Johns Hopkins University, through its leadership and a wide array of research-related resources.

PI_NAMEs: JENNINGS, JACKY M;TAHA, TAHA E (contact)

PROGRAM_OFFICER_NAME: CASTILLO, BLANCA E

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Adolescent;Adult;Affect;Africa;Africa South of the Sahara;age group;AIDS prevention;Area;Basic Science;Behavior Therapy;Child;Childhood;Cities;Clinical;Clinical Management;Clinical Research;clinical research site;Clinical Trials;Clinical Trials Cooperative Group;Clinical Trials Network;Clinical Trials Unit;Collaborations;college;Communication;Communities;community collaboration;community engagement;Country;Data;data management;Development;Elements;Ensure;Epidemic;Ethics;Evaluation;experience;flexibility;Generations;Goals;Health;high standard;HIV;HIV Infections;HIV prevention trials network;HIV Seronegativity;HIV Seropositivity;HIV Vaccine Trials Network;HIV-1;HIV/AIDS;Individual;Information Technology;Infrastructure;Institution;International;Laboratories;Leadership;Malawi;Medicine;Mentors;Microbicide Trials Network;Modality;National Institute of Allergy and Infectious Disease;Occupational activity of managing finances;Office of Administrative Management;operation;Patient Self-Report;Persons;Pharmacy facility;Policies;Population;Prevalence;prevent;Prevention;Prevention Research;Preventive;Principal Investigator;programs;Prophylactic treatment;Protocols documentation;Regimen;Research;Research Infrastructure;Research Priority;research study;Resources;Risk;Role;Scientific Advances and Accomplishments;Site;social interventions;statistics;Structure;support network;Surveys;Testing;Therapeutic Clinical Trial;Training;treatment research;United States National Institutes of Health;Universities;Vaccine Research;vaccine trial;Vaccines;Viral Load result;Work

PROJECT_TITLE: The Johns Hopkins University-Blantyre Clinical Trials Unit


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

ORG_CITY: HADLEY

ORG_NAME: UNIVERSITY OF MASSACHUSETTS AMHERST

ORG_STATE: MA

PHR: PROJECT NARRATIVE Any successful immune response depends on the proper maintenance and differentiation of the involved cells. The CD8 T cell-mediated immune response is often compromised during chronic infection and cancer. Our studies not only will investigate a novel posttranscriptional mechanism that profoundly influences both the maintenance and the differentiation of CD8 T cells but will also provide a rational for developing new immunotherapies.

PI_NAMEs: POBEZINSKIY, LEONID  (contact)

PROGRAM_OFFICER_NAME: JIANG, CHAO

PROJECT_TERMS: Ablation;Acute;Address;Adoptive Immunotherapy;Antigens;Antitumor Response;Apoptotic;BCL2 gene;Cancerous;CD8-Positive T-Lymphocytes;Cell Differentiation process;Cell Maintenance;cell mediated immune response;Cell Survival;Cells;Chronic;chronic infection;Clinical;Clonal Expansion;cytokine;cytotoxic;Cytotoxic T-Lymphocytes;Data;Defect;Effector Cell;effector T cell;Environment;exhaust;exhaustion;Exhibits;experimental study;Family;gain of function;Generations;Genetic;Goals;Granzyme;Homeostasis;Immune response;Immunologic Memory;Immunotherapy;improved;in vivo;Infection;Inflammation;insight;Interferon Type II;Laboratories;Lead;Longevity;loss of function;Lymphocyte;Maintenance;Malignant Neoplasms;Mediating;Memory;Metabolic;MicroRNAs;Modeling;Molecular;new therapeutic target;novel;Outcome;pathogen;Pathologic;perforin;Performance;Play;Post-Transcriptional Regulation;posttranscriptional;prevent;Production;programs;Proliferating;Publishing;Regulation;Role;success;T cell differentiation;T memory cell;T-Cell Receptor;T-Lymphocyte;Testing;transcription factor;Transcriptional Regulation;tumor;tumor growth;Tumor-Derived;Viral

PROJECT_TITLE: Defining post-transcriptional mechanisms that control CD8 T cell longevity, proliferation and differentiation

STUDY_SECTION: CMIA

STUDY_SECTION_NAME: Cellular and Molecular Immunology - A Study Section[CMIA]


NIH_SPENDING_CATS: Behavioral and Social Science;Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Emerging Infectious Diseases;HIV/AIDS;Hepatitis;Hepatitis - B;Immunization;Infectious Diseases;Liver Disease;Pediatric;Prevention;Rare Diseases;Tuberculosis;Vaccine Related

ORG_CITY: CHIANG MAI

ORG_COUNTRY: THAILAND

ORG_FIPS: TH

ORG_NAME: CHIANG MAI UNIVERSITY

PHR: Thailand HIV/AIDS and Infectious Disease Clinical Trials Unit (THAI CTU)  SF 424 (R&R) Other Project Information – Project Narrative The Thailand HIV/AIDS and Infectious Disease Clinical Trials Unit (THAI CTU) is a collaboration between the Chiang Mai University-Research Institute for Health Sciences (CMU-RIHES) in Chiang Mai, Thailand, and the Thai Red Cross AIDS Research Centre (TRC-ARC) in Bangkok, Thailand. The renewed THAI CTU and its four CRSs will participate in developing and conducting clinical trials proposed by the four NIH HIV/AIDS Clinical Trials Networks: HIV/AIDS adult therapeutics; HIV/AIDS maternal, adolescent and pediatric therapeutics; HIV prevention; and HIV vaccines. The collaboration between the NIH HIV/AIDS Clinical Trials Networks and their affiliated CTUs, including the THAI CTU, will lead to development of innovative and effective measures for HIV treatment and prevention, and ultimately to HIV cure and an end to the global HIV epidemic.

PI_NAMEs: RUXRUNGTHAM, KIAT ;SUPPARATPINYO, KHUANCHAI  (contact)

PROGRAM_OFFICER_NAME: JALLAH, ODAV MARDEA

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Adolescent;adolescent men who have sex with men;Adult;AIDS prevention;Anti-Retroviral Agents;antiretroviral therapy;Behavioral Sciences;Biological;Childhood;clinical development;Clinical Research;clinical research site;Clinical Treatment;Clinical Trials;Clinical Trials Network;Clinical Trials Unit;co-infection;Collaborations;Communicable Diseases;comorbidity;Conduct Clinical Trials;Development;diagnostic technologies;Disease remission;Drug resistance in tuberculosis;drug-sensitive;Epidemic;Epidemiology;Evaluation;Health Sciences;Hepatitis B;Hepatitis B Infection;Hepatitis B Virus;Hepatitis C;high-risk adolescents;HIV;HIV vaccine;HIV Vaccine Trials Network;HIV/AIDS;Immunologics;Incidence;Infant;Infrastructure;Injecting drug user;innovation;Intervention;Investigation;Laboratories;Measures;National Institute of Allergy and Infectious Disease;neutralizing antibody;novel;Opiate Addiction;Outcome;Participant;Passive Immunization;Persons;Pharmacy facility;Population;pre-exposure prophylaxis;Pregnancy;Prevention;Principal Investigator;recruit;Red Cross;Research;Research Institute;Research Priority;Sexually Transmitted Diseases;Site;Social Sciences;System;Technology;Thailand;Therapeutic;Therapeutic Clinical Trial;transgender women;treatment center;Tuberculosis;United States National Institutes of Health;Universities;Vaccination;vaccination against tuberculosis;Viral hepatitis;Virus Diseases


NIH_SPENDING_CATS: Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Endocrine Disruptors;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Social Determinants of Health

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE: The Columbia Center for Children’s Environmental Health (CCCEH) requests infrastructure support to maintain retention and engagement of its unique environmental cohorts, enhance basic laboratory and data management resources, increase community outreach efforts, and set the stage for new partnerships and training opportunities to evaluate cumulative oxidative damage from prenatal exposure to mixtures of environmental pollutants. Given that the CCCEH cohorts are comprised of mothers and children who are low-income and minority (largely African-American and Latino), retaining the participants, their associated biorepositories, and the environmental health data they have provided over the past 20 years is of critical importance. Support will facilitate our efforts to preserve CCCEH unique resources, guide behaviors, and inform policies to reduce exposures of pregnant women and children to toxic chemicals and pollutants.

PI_NAMEs: HERBSTMAN, JULIE BETH (contact);PERERA, FREDERICA P

PROGRAM_OFFICER_NAME: GRAY, KIMBERLY A

PROJECT_TERMS: African American;aged;Applications Grants;Aromatic Polycyclic Hydrocarbons;Award;Behavior;biobank;Biological;Biological Markers;Birth;bisphenol A;Chemicals;Child;Childhood;Cities;cohort;Collaborations;Collection;Color;Communication;Communities;Community Outreach;community partners;Consent;Data;Data Coordinating Center;data management;Data Management Resources;Databases;Discipline;Disease;Education;Electronics;Elements;Enrollment;Ensure;Environment;Environmental Epidemiology;Environmental Health;environmental justice;Environmental Pollutants;environmental tobacco smoke;Equipment and supply inventories;experience;Exposure to;Flame Retardants;Foundations;Funding;Gifts;Grant;Health;health assessment;health data;health record;Health Resources;high throughput screening;improved;in utero;Infrastructure;insight;inter-institutional;Interdisciplinary Study;Laboratories;Latino;Letters;Low income;Magnetic Resonance Imaging;Measures;medical schools;mental health counseling;Methods;Mexico;Minority;Mitochondria;Mitochondrial DNA;Modeling;Molecular Epidemiology;Mothers;neurodevelopment;new technology;Newborn Infant;novel;novel marker;Outcome;outreach;oxidative damage;Participant;participant enrollment;participant retention;patient engagement;payment;Pesticides;Philanthropic Fund;phthalates;Poison;Policies;pollutant;polybrominated diphenyl ether;Population;pregnant;Pregnant Women;prenatal environmental exposure;prenatal exposure;Preparation;preservation;prevent;Privatization;Psychologist;Quality Control;recruit;Research Personnel;Resources;screening program;Secure;Services;Siblings;Standardization;student training;Students;Surveys;Technology;Teenagers;tool;Toxic effect;training opportunity;Translations;user-friendly;volunteer;Work;Youth

PROJECT_TITLE: To Maintain and Enrich Resource Infrastructure for Existing Environmental Epidemiology Cohorts


NIH_SPENDING_CATS: Obesity

ORG_CITY: SCOTTSDALE

ORG_NAME: MAYO CLINIC ARIZONA

ORG_STATE: AZ

PHR: Project Narrative  Obesity is a major public health problem around the world, however effective prevention and long-term management are suboptimal. This project is focused on a receptor for a GI hormone that mediates post-cibal satiety, but that is negatively affected by elevated cholesterol in the membrane, which can be present in obesity. In this project, we will explore the physical and functional basis for this lipid sensitivity, in hopes of gaining insights to correct the abnormal responsiveness to this satiety agent.

PI_NAMEs: MILLER, LAURENCE J (contact)

PROGRAM_OFFICER_NAME: LEWIS, MECHELLE MAYLEBEN

PROJECT_TERMS: Acute;Address;Affect;Afferent Neurons;Affinity;Agonist;antagonist;Binding;Biology;Cell membrane;Cholecystokinin;Cholecystokinin Receptor;Cholesterol;Chronic;Clinical Medicine;Clinical Trials;Collaborations;Complex;Coupling;Cryoelectron Microscopy;Data;Development;dieting;Disease;Docking;drug development;drug discovery;Drug Receptors;Drug Targeting;Environment;Event;Exhibits;experience;extracellular;Face;feeding;Fluorescence;G-Protein-Coupled Receptors;genetic regulatory protein;GTP-Binding Proteins;Heterotrimeric GTP-Binding Proteins;Hormones;insight;Investigation;Kinetics;Knowledge;Lateral;Ligand Binding;Ligands;Link;Lipids;Mediating;Membrane;Membrane Lipids;Methodology;Molecular;Molecular Conformation;molecular site;mutant;novel;obese person;Obesity;obesity treatment;Occupations;patient subsets;Peptides;Persons;Pharmaceutical Preparations;Pharmacology;Photoaffinity Labels;Physiological;Population;Prevention;Process;Public Health;receptor;receptor function;recruit;Refractory;Regulation;Research Personnel;Resistance;Resolution;response;Satiation;Scaffolding Protein;screening;Series;side effect;Signal Transduction;Sincalide;Site;skills;Stimulus;structural biology;Structure;System;Texture;Therapeutic;Therapeutic Effect;therapeutic target;Toxic effect;trafficking;Work

PROJECT_TITLE: Impact of membrane composition on cholecystokinin receptor structure and function

STUDY_SECTION: MIST

STUDY_SECTION_NAME: Molecular and Integrative Signal Transduction Study Section[MIST]


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Bioengineering;Chronic Liver Disease and Cirrhosis;Digestive Diseases;HIV/AIDS;Hepatitis;Hepatitis - B;Hepatitis - C;Infectious Diseases;Liver Disease

ORG_CITY: Los Alamos

ORG_NAME: TRIAD NATIONAL SECURITY, LLC

ORG_STATE: NM

PHR: NARRATIVE Even with better and simpler treatments HIV-1 is still a life-long infection for millions of people. The major barrier to cure is the latent reservoir. Here we will study multiple datasets and develop mechanistic models to understand how the reservoir is established and maintained. We will also examine patient specific factors that determine the time after therapy discontinuation that virus rebounds or is controlled. We also will model the effects of new treatments for hepatitis B infection, another viral illness in which current therapy is generally life-long, and for which novel approaches may lead to functional cure.

PI_NAMEs: PERELSON, ALAN S (contact)

PROGRAM_OFFICER_NAME: VONKOLLMAR, DESIREE

PROJECT_TERMS: acute infection;Address;Aftercare;Anti-Retroviral Agents;Anti-viral Agents;Anti-viral Therapy;antiretroviral therapy;Back;Berlin;Binding;Biological;Biological Markers;Biology;Cells;Clinical;Clinical Data;Clinical Trials;Collaborations;Collection;Communities;Data;Data Set;design;detection limit;Development;Differential Equation;diverse data;Drug Combinations;Drug Industry;drug mechanism;Effectiveness;experience;Frustration;Generations;Genetic;Goals;Grant;Hepatitis B;Hepatitis B Infection;Hepatitis B Therapy;Hepatitis B Virus;Hepatitis C;Hepatitis C virus;HIV;HIV Antigens;HIV-1;HIV/HCV;Human;Immune;in vivo;Individual;Infection;innovation;insight;Interruption;Intervention;Knowledge;latent HIV reservoir;Literature;London;Maintenance;mathematical model;Modeling;multi-scale modeling;multiple datasets;New Agents;nonhuman primate;novel;novel strategies;novel therapeutics;Participant;Patients;Persons;Pharmaceutical Preparations;Play;Process;purge;response;RNA;Scientist;success;T-Lymphocyte;Testing;Time;Viral;Viral Load result;viral rebound;Viral reservoir;Virus;Virus Diseases;Withholding Treatment

PROJECT_TITLE: Modeling Viral and T Lymphocyte Dynamics


NIH_SPENDING_CATS: Lung;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

PHR: NARRATIVE The proposed research is relevant to public health because anticipated results will determine the mechanism(s) that maintains the alveolar macrophage population in health and disease and inform the therapeutic mechanism of action of a new type of cell transplantation – pulmonary macrophage transplantation (PMT) therapy, which we are developing to treat children with hereditary pulmonary alveolar proteinosis and potentially patients with other lung diseases. The proposed research is relevant to the NIH’s mission pertaining to the development of fundamental knowledge that can be used to reduce the burden of human illness by identifying the cell source used for alveolar macrophage self-renewal and elucidating the mechanism(s) responsible for maintaining the size of alveolar macrophage population in health and disease.

PI_NAMEs: ARUMUGAM, PARITHA  (contact)

PROGRAM_OFFICER_NAME: GOMEZ, CHRISTIAN RENE

PROJECT_TERMS: Adult;Agonist;Alveolar Macrophages;Biochemical;Biogenesis;Cell Count;Cell Cycle Regulation;Cell Differentiation process;Cell Line;Cell Proliferation;Cell Survival;Cell Therapy;cell type;Cells;Child;Confocal Microscopy;CSF2RB gene;Data;Development;Disease;Dyes;Enabling Factors;Evaluation;fatty acid oxidation;Fatty Acids;Feedback;Flow Cytometry;Foundations;Gene Expression Profiling;Genes;Genetic;Genus Hippocampus;Goals;Granulocyte-Macrophage Colony-Stimulating Factor;Growth;Half-Life;Health;hematopoietic stem cell self-renewal;Hematopoietic stem cells;Homeostasis;Hormones;Human;Impairment;improved;in vivo;Inherited;inhibitor;innovation;Interphase Cell;JAK2 gene;Knowledge;Leukemic Cell;Ligands;Lung;Lung Diseases;Lung Transplantation;Macrophage;Macrophage Colony-Stimulating Factor;Maintenance;Measures;Mediating;Membrane Potentials;Metabolism;Methodology;Methods;Minor;Mission;Mitochondria;mitochondrial metabolism;Molecular;monocyte;mouse model;Mus;Nature;novel;novel therapeutic intervention;novel therapeutics;oxidation;Pathway interactions;Patients;pharmacologic;Phase;Phospholipids;Play;Population;Population Sizes;Process;Production;progenitor;Proliferating;Proteins;Public Health;Pulmonary Alveolar Proteinosis;Reactive Oxygen Species;receptor;Receptor Signaling;Regulation;Regulator Genes;Reporting;Research;Resolution;Respiration;Role;self renewing cell;self-renewal;Signal Transduction;Source;Stains;stem cell expansion;stem cell proliferation;surfactant;Technology;Testing;Therapeutic;tool;transcription factor;Transcriptional Regulation;transcriptome sequencing;Transplantation;transplantation therapy;United States National Institutes of Health;vector

PROJECT_TITLE: Role of GM-CSF in Alveolar Macrophage Self-Renewal

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Burden of Illness;Climate-Related Exposures and Conditions;Clinical Research;Emerging Infectious Diseases;Infectious Diseases;Prevention;Rare Diseases;Social Determinants of Health;Valley Fever

ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: Project Narrative This project addresses gaps in our understanding of the kinds of dust exposures, and the environmental and social conditions, that increase the incidence of coccidioidomycosis in the southwest. The findings will have wide-ranging benefits for public health, including a better understanding of how people are exposed to the pathogen, the identification of areas and people that are at the highest risk, and predictions of future coccidioidomycosis that can be used to prevent infection in vulnerable groups.

PI_NAMEs: REMAIS, JUSTIN V (contact)

PROGRAM_OFFICER_NAME: LOVE, DONA

PROJECT_TERMS: Address;Air;Area;burden of illness;California;Cessation of life;Charge;Chronic;Climate;Climatology;Coccidioides;Coccidioides immitis;Coccidioides posadasii;Coccidioidomycosis;Crossover Design;Data;Data Collection;density;design;Development;Disease;Disease Outbreaks;Dose;Droughts;Dust;Economic Burden;Economics;Elderly;Environment;environmental intervention;Environmental Risk Factor;Environmental Wind;Epidemic;Epidemiology;Event;experience;Exposure to;fungus;Future;Goals;Heterogeneity;high risk;High temperature of physical object;Hospitalization;Human;Incidence;Individual;Infection;Infection prevention;infection rate;infection risk;Influenza;Inhalation;Knowledge;Laboratories;Lung infections;Measures;Meningitis;Methods;Modeling;Monitor;novel;pathogen;Pathogen detection;pathogen exposure;Pattern;Performance;Persons;Population;Population Analysis;predictive modeling;Proliferating;prospective;Public Health;Rain;Records;remote sensing;Reproduction spores;Research;Resolution;response;Retrospective cohort;Risk;Risk Factors;Sampling;Seasons;Social Conditions;sociodemographics;Soil;Source;spatiotemporal;statistical and machine learning;Subgroup;Symptoms;temporal measurement;Testing;Time;timeline;transmission process;Variant;Vulnerable Populations

PROJECT_TITLE: Integrating epidemiologic and environmental approaches to understand and predict Coccidioides exposure and coccidioidomycosis emergence

STUDY_SECTION: IRAP

STUDY_SECTION_NAME: Infectious Diseases, Reproductive Health, Asthma and Pulmonary Conditions Study Section[IRAP]


NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Brain Disorders;Clinical Research;Digestive Diseases;Genetics;Human Genome;Immunotherapy;Multiple Sclerosis;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Information generated from the proposed studies will not only advance our understanding of the c-Rel biology in MS, but also aid in developing novel c-Rel blocking drugs for the treatment of inflammatory diseases. Therefore, this project should advance both scientific knowledge and clinical management of MS.

PI_NAMEs: JORDAN, MARTHA S (contact)

PROGRAM_OFFICER_NAME: GUERAU, MIREIA

PROJECT_TERMS: Acceleration;Animal Model;Animals;Antigens;Arthritis;Autoimmune Diseases;Autoimmune Responses;autoimmunity checkpoint;Binding;Biochemical;Biology;Celiac Disease;Cell Differentiation process;Cell Physiology;cell type;Cells;Central Nervous System Diseases;ChIP-seq;Clinical Management;Colitis;Development;Disease;Disease Progression;DNA;Drug Targeting;experience;Experimental Autoimmune Encephalomyelitis;Family;FDA approved;Genes;Genetic;Genetic Transcription;genome wide association study;genome-wide;Goals;Health;Human;Immune response;Immunologics;Infection;Inflammatory;inhibitor;Interferons;Knock-out;Knockout Mice;Knowledge;Knowledge Management;Legal patent;Lymphoid;Lymphoid Cell;Mediating;member;Modeling;Multiple Sclerosis;multiple sclerosis patient;multiple sclerosis treatment;Mus;Myelin;Myelogenous;Myeloid Cells;novel;Nuclear;Pathologic;Patients;peripheral blood;Persons;Pharmaceutical Preparations;Pharmacologic Substance;Pharmacotherapy;Play;prevent;primary sclerosing cholangitis;Psoriasis;Recovery;Regulatory T-Lymphocyte;Relapse;Reporting;Research Proposals;Resistance;Rheumatoid Arthritis;Risk Factors;Role;Small Interfering RNA;small molecule;T-Lymphocyte;Testing;theories;Therapeutic;therapeutically effective;Time;time use;Ulcerative Colitis;United States;Virulence Factors

PROJECT_TITLE: Transcriptional Checkpoints Of Autoimmune Encephalomyelitis


NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_CITY: GREENVILLE

ORG_NAME: EAST CAROLINA UNIVERSITY

ORG_STATE: NC

PHR: Project Narrative Despite current therapies, the 5-year mortality after myocardial infarction (MI, commonly known as heart attack) is 40% due to persistent tissue degradation that leads to adverse remodeling of the left ventricle (LV). We developed a peptide that modulates tissue degradation by proteases; this peptide significantly reduces adverse remodeling post-MI by changing the inflammatory profile and directly interacting with reparative cells. This proposal will study the mechanisms underlying the peptide mode of action to explore new therapeutic avenues and, therefore, enhance our fundamental knowledge on the mechanisms of adverse LV remodeling.

PI_NAMEs: DE CASTRO BRAZ, LISANDRA E (contact)

PROJECT_TERMS: Actins;Biological;Cardiac;Cells;cellular targeting;Cicatrix;Clinical Trials;Collagen;Congestive Heart Failure;Data;Death Rate;Deposition;Diagnosis;Drug or chemical Tissue Distribution;Equilibrium;Event;Extracellular Matrix;Extracellular Matrix Degradation;Family;Fiber;Fibroblasts;Fibrosis;Foundations;Gelatinase B;Generations;Heart failure;heart function;Human;improved;In Vitro;in vivo;Infarction;Infiltration;Inflammation;Inflammatory;Inflammatory Response;Inhibition of Matrix Metalloproteinases Pathway;inhibitor;innovation;Integrin alpha4;Integrins;Knowledge;Left Ventricular Remodeling;Left ventricular structure;Macrophage;mass spectrometric imaging;Matrix Metalloproteinase Inhibitor;Matrix Metalloproteinases;Mediating;migration;mimetics;Molecular;monocyte;mortality;multiple reaction monitoring;Mus;Myocardial;Myocardial dysfunction;Myocardial Infarction;neutrophil;novel;novel therapeutics;paracrine;Paracrine Communication;Pathway interactions;Patients;Peptide Hydrolases;Peptide Receptor;Peptides;pharmacologic;Phase;Phenotype;Physiology;Plasma;polymerization;Polymers;predict clinical outcome;preference;pressure;Process;prognostic indicator;Proteolysis;Proteomics;receptor;repaired;Reporting;Resolution;response;rho GTP-Binding Proteins;Role;Signal Pathway;Signal Transduction;Specificity;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;synthetic peptide;Testing;Therapeutic;Tissues;Transgenic Animals;Visualization

PROJECT_TITLE: Collagen-derived peptides to target inflammation in myocardial infarction


NIH_SPENDING_CATS: Antimicrobial Resistance;Clinical Research;Clinical Trials and Supportive Activities;Cost Effectiveness Research;Dissemination and Implementation Research;Health Services;Infectious Diseases;Lung;Primary Health Care

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Narrative The proposed project is relevant to public health because it seeks to decrease inappropriate antibiotic use in acute respiratory infections which leads to antibiotic resistance. We will adapt our innovative clinical decision support, that uses evidence-based rules to determine risk of bacterial infection, for use in nurse led evaluation and treatment of patients with acute respiratory infections. We will determine if the nurse driven clinical decision support decreases antibiotic prescriptions, diagnostic testing and cost of care.

PI_NAMEs: FELDSTEIN, DAVID ALAN;MANN, DEVIN M (contact)

PROGRAM_OFFICER_NAME: SASTALLA, INKA I

PROJECT_TERMS: Acute;Acute Disease;Acute respiratory infection;Adoption;Ambulatory Care;Antibiotic Resistance;Antibiotics;Bacterial Infections;care costs;Caring;Chronic Disease;Client satisfaction;Clinic;Clinical;clinical care;clinical decision support;clinical predictors;Cluster randomized trial;cluster trial;Collaborations;cost;Cost Analysis;cost effectiveness;Coughing;Data;Decision Aid;Diagnosis;Diagnostic tests;Electronic Health Record;Elements;empowerment;Evaluation;evidence base;Fatigue;Foundations;Funding;Goals;Health;health care quality;Healthcare;implementation evaluation;implementation framework;implementation outcomes;implementation tool;improved;Information Technology;innovation;Institution;Intervention;intervention cost;Laboratories;Lead;Licensing;Modeling;Morbidity - disease rate;National Institute of Allergy and Infectious Disease;New York;novel;Nurses;Outcome;Patient Care;Patient risk;Patients;Pattern;Persons;Physical Examination;Physicians;post implementation;Preventive;Primary Care;Proctor framework;Protocols documentation;Provider;Public Health;Recommendation;Recording of previous events;Registered nurse;Research;Resources;Risk;risk stratification;Sore Throat;Standardization;success;support tools;Technology;Telephone;Testing;theories;Time;tool;Training;Training Programs;Triage;Universities;uptake;urgent care;Utah;Visit;Wisconsin;Work

PROJECT_TITLE: Decreasing antibiotic prescribing in acute respiratory infections through implementation of nurse driven clinical decision support

STUDY_SECTION: DIRH

STUDY_SECTION_NAME: Dissemination and Implementation Research in Health Study Section[DIRH]


NIH_SPENDING_CATS: Behavioral and Social Science;Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Emerging Infectious Diseases;HIV/AIDS;Hepatitis;Immunization;Infectious Diseases;Liver Disease;Prevention;Rare Diseases;Tuberculosis;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: Rio de Janeiro

ORG_COUNTRY: BRAZIL

ORG_FIPS: BR

ORG_NAME: FUNDACAO OSWALDO CRUZ

PHR: FioTrials Project Narrative The past decade has seen unprecedented progress in strategies for HIV prevention and treatment. The FioTrials CTU is committed to a partnership with the ACTG, HPTN, and HVTN Networks to conduct and design clinical trials that reduce the burden of HIV, Tuberculosis, and Hepatitis among populations living with HIV and those at risk of acquiring these infections. Through our strong ties to the community, the FioTrials CTU has expertise with working with vulnerable populations and we are confident that our ongoing efforts and progress will contribute to the end of the HIV epidemic and improving public health globally.

PI_NAMEs: GRINSZTEJN, BEATRIZ  (contact)

PROGRAM_OFFICER_NAME: TUCKER, JENESE

PROJECT_TERMS: Advocate;Affect;AIDS clinical trial group;AIDS prevention;authority;Belief;Brazil;Caring;Clinical Management;Clinical Research;clinical research site;Clinical Trials;Clinical Trials Design;Clinical Trials Unit;Collaborations;Communicable Diseases;Communication;Communities;community involvement;comorbidity;Developing Countries;Ensure;Epidemic;European;experience;Foundations;Funding;Gender;Generations;global health;Goals;Good Clinical Practice;Health Personnel;Hepatitis;HIV;HIV Vaccine Trials Network;HIV/AIDS;HIV/TB;Hospitals;improved;Individual;Infection;innovation;insight;international center;Leadership;Licensure;Nongovernmental Organizations;novel;Participant;Population;Prevention;Process;programs;Public Health;Race;Research;Research Personnel;Rewards;Risk;Sex Orientation;Site;social;Solid;Standardization;success;Therapeutic;Tuberculosis;United States National Institutes of Health;Vulnerable Populations

PROJECT_TITLE: The FIOCRUZ Therapeutic and Prevention HIV/AIDS Clinical Trials Unit.


NIH_SPENDING_CATS: Cardiovascular;Genetics;Heart Disease

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: Project Narrative We propose that heart failure is partially due to a progressive loss of EC identity, and TCF4 dysregulation plays a driver role in this EC dysfunction. Successful completion of this proposal will define TCF4 as a novel EC identity gene. Therapeutic modulation of EC specific TCF4 delivery may be a novel and promising approach for heart failure and cardiac fibrosis.

PI_NAMEs: ZHANG, LILI  (contact)

PROJECT_TERMS: Angiotensin II;Attenuated;autocrine;Bioinformatics;Biological Assay;Blood Vessels;Cardiac;Cell secretion;cell type;Cells;Chronic;Coculture Techniques;Communication;Computer Models;Confusion;Coronary artery;coronary fibrosis;Data;density;Diastolic blood pressure;Down-Regulation;Endothelial Cells;endothelial dysfunction;Endothelium;Enhancers;Epigenetic Process;epithelial to mesenchymal transition;Exhibits;Fibroblasts;Fibrosis;Foundations;Functional disorder;gain of function;gene discovery;Gene Expression;Gene Silencing;Genes;Genetic;Genomics;Heart;Heart failure;histone modification;Impairment;In Vitro;in vivo Model;Incidence;Infusion procedures;insight;intercellular communication;Intercellular Fluid;interstitial;Knowledge;Literature;loss of function;Lung;machine learning model;Maintenance;marine;Mediating;Mesenchymal;Modeling;Molecular;Morbidity - disease rate;mortality;Myocardial;Myofibroblast;Nature;novel;Outcome;overexpression;paracrine;Pathway interactions;Patients;Performance;PF4 Gene;Phenotype;Play;prevent;Protein Secretion;Reporting;Repression;Role;System;targeted treatment;TCF Transcription Factor;TCF7L2 gene;Testing;Therapeutic;Time;Tissues;transcription factor;transdifferentiation;Transforming Growth Factor beta;Vascular Endothelial Cell;Vasodilation;Ventricular;Work

PROJECT_TITLE: Transcription Factor 4 Maintain Endothelial identity to Oppose Heart Failure

STUDY_SECTION: MPPA

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology A Study Section [MPPA]


NIH_SPENDING_CATS: Behavioral and Social Science;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);HIV/AIDS;Immunization;Infectious Diseases;Prevention;Substance Misuse;Vaccine Related;Vaccine Related - AIDS

PHR: PROJECT NARRATIVE Despite recent breakthroughs in HIV treatment and prevention, many obstacles remain. The Penn HIV Clinical Trials Unit will test new strategies that will improve HIV treatment and advance the goal of curing people living with HIV infection. We will also test novel, long-acting strategies to prevent HIV infection.

PI_NAMEs: FRANK, IAN  (contact);TEBAS, PABLO

PROGRAM_OFFICER_NAME: GREENFIELD, TERI L

PROJECT_TERMS: Achievement;Adherence;Adolescent;Adult;Affect;AIDS clinical trial group;AIDS prevention;Anti-Retroviral Agents;antiretroviral therapy;Behavior Therapy;Behavioral Research;Biology;Cardiovascular Diseases;career development;Caring;Cells;Chronic Kidney Failure;cis-female;Cities;Clinical Investigator;Clinical Research;clinical research site;clinical trial implementation;Clinical Trials;Clinical Trials Unit;Communities;comorbidity;Conduct Clinical Trials;Consequences of HIV;cost efficient;Creativeness;design;Diagnosis;Drug Interactions;Dyslipidemias;Education;Effectiveness;Epidemic;Evaluation;Event;Faculty;Failure;frailty;gender nonconforming;Goals;Hepatitis B Virus;Heterosexuals;HIV;HIV Infections;HIV prevention trial;HIV therapy;HIV vaccine;Human immunodeficiency virus test;immune activation;immune function;Immune response;Immunologics;implantable device;improved;Incentives;Individual;Infection;Infection Control;Infrastructure;Injectable;Injecting drug user;International;Investigation;latent HIV reservoir;Leadership;Maintenance Therapy;Medical;medical schools;men who have sex with men;Mentors;microbicide;Monoclonal Antibodies;Mucous Membrane;Network Infrastructure;neutralizing monoclonal antibodies;New Agents;next generation;non-alcoholic fatty liver disease;novel;novel therapeutics;Obesity;Oral;outbreak response;Outcome;Pathogenesis;Pennsylvania;Persons;Phenotype;Philadelphia;Physical Function;physical impairment;Population;Populations at Risk;Positioning Attribute;pre-exposure prophylaxis;prevent;Prevention;Prevention strategy;preventive intervention;protocol development;Protocols documentation;purge;Recovery;Research;Research Personnel;Resources;Risk;Risk Behaviors;Role;Science;senescence;shared decision making;Site;Structure;Support Groups;symposium;Testing;Therapeutic;therapy design;Training;transgender;treatment as prevention;treatment response;Treatment-related toxicity;Tuberculosis;Universities;uptake;vaccine trial;Virus Activation;Vision;Work

PROJECT_TITLE: University of Pennsylvania HIV Clinical Trials Unit


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Neurosciences;Pediatric

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

PHR: PROJECT NARRATIVE The proposed study will investigate the organization of speech sound representations in the developing brain from childhood to adolescence. In addition to its overall organization for speech, we will determine how the brain is able to segment continuous speech sounds in different contexts, including when speech is self- generated or occurs in the presence of noise or other competing information. Understanding such processes will inform developmental milestones for brain development, and could lead to brain-based treatments of language disorders delayed language learning and dyslexia.

PI_NAMEs: HAMILTON, J LIBERTY S (contact)

PROGRAM_OFFICER_NAME: POREMBA, AMY

PROJECT_TERMS: 1 year old;Acoustics;Address;Adolescence;Adolescent;Adult;Age;age related changes;Anterior;Aphasia;Area;Articulation Disorders;Attention;attentional modulation;Auditory;Auditory area;Auditory Perceptual Disorders;autism spectrum disorder;behavior measurement;Bilateral;Biological Markers;Brain;brain based;brain computer interface;Child;Childhood;Classification;Communication;comorbidity;Complex;Data Set;Detection;Development;Disease;Dyslexia;early childhood;educational atmosphere;Electrophysiology (science);Epilepsy;Event;expectation;experimental study;Face;Genetic Transcription;Goals;Human;improved;innovation;insight;Intervention;Intractable Epilepsy;Language;Language Delays;Language Development;Language Development Disorders;Language Disorders;Learning;Linguistics;Location;Measures;Methods;Motor;neural;neurodevelopment;neurofeedback;neuromechanism;neurophysiology;Noise;Operative Surgical Procedures;Organizational Change;Participant;Patients;pediatric patients;Perception;Phonetics;phonological awareness;phonology;phrases;Procedures;Process;Production;Research;research clinical testing;Resolution;response;Role;Signal Transduction;social;sound;spatiotemporal;Speech;Speech Development;Speech Disorders;speech in noise;Speech Perception;speech processing;Speech Sound;Stimulus;Superior temporal gyrus;Temporal Lobe;temporal measurement;Testing;therapeutic target;verbal;Voice;Wernicke Area;Work

PROJECT_TITLE: Electrophysiological Approaches to Understanding Functional Organization of Speech in the Brain

STUDY_SECTION: LCOM

STUDY_SECTION_NAME: Language and Communication Study Section[LCOM]