NIH_SPENDING_CATS: Brain Disorders;Cardiovascular;Cerebrovascular;Childhood Injury;Heart Disease;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Physical Injury - Accidents and Adverse Effects;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Stroke;Unintentional Childhood Injury

ORG_CITY: PITTSBURGH

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Quality survival after brain injury is currently the greatest challenge for critically ill or injured infants and children. A universal contributor limiting quality survivorship is the devastating impact of hypoxic-ischemic encephalopathy. This research aims to synthesize and develop novel mitochondria-targeting therapeutics, toward meaningfully improving neurological outcome and quality of life in infants and children suffering from cerebral hypoxia-ischemia.

PI_NAMEs: BAYIR, HÜLYA ;CLARK, ROBERT S B (contact)

PROGRAM_OFFICER_NAME: BOSETTI, FRANCESCA

PROJECT_TERMS: Adolescence;Aerobic;Aftercare;Age;age difference;Antioxidants;apoptosis inducing factor;Brain;Brain Injuries;Brain region;Cell Death;Cell Death Signaling Process;Cell Respiration;Cerebral Ischemia;Cerebral Ischemia-Hypoxia;Cerebrum;Child;Childhood;Clinical;cognitive testing;Computer Models;Consumption;Critical Illness;Data;deprivation;Development;DNA Damage;DNA Repair;Dose;druggable target;Event;Failure;Female;Generations;Glucose;Gramicidin S;Heart Arrest;Histologic;Image;improved;In Vitro;in vivo;in vivo imaging;infancy;Infant;inhibitor;Injury;Intracranial Hemorrhages;Ischemia;Link;lipidomics;liquid chromatography mass spectrometry;male;Mediating;metabolic rate;Metabolism;Mitochondria;Mitochondrial DNA;mitochondrial therapeutics;Modeling;Motor;NADH;nanomolar;Necrosis;neonatal hypoxic-ischemic brain injury;Nerve Degeneration;neuroinflammation;Neurological outcome;neuron loss;neuronal survival;neuroprotection;novel;Nuclear;Organism;Outcome;Oxygen;Pathogenesis;Pharmaceutical Preparations;Placebos;Poly Adenosine Diphosphate Ribose;Poly(ADP-ribose) Polymerase Inhibitor;Poly(ADP-ribose) Polymerases;Polymers;postnatal;preservation;prevent;Quality of life;Randomized;Rattus;Reactive Oxygen Species;Regimen;release factor;Reporting;Research;Role;Septic Shock;severe injury;sex;Shock;Source;Status Epilepticus;Stroke;Structure-Activity Relationship;superresolution microscopy;survivorship;Therapeutic;Time;tool;translational potential;Traumatic Brain Injury;Western Blotting

PROJECT_TITLE: Druggable Mitochondrial Targets for Treatment of Cerebral Ischemia

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


ADMINISTERING_IC: DC

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Clinical Research;Coronaviruses;Emerging Infectious Diseases;Infectious Diseases;Neurosciences;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: BALTIMORE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: OTOLARYNGOLOGY

ORG_FIPS: US

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: NARRATIVE The olfactory epithelium is not only important for the sense of smell, but also as a site of immune defense against inhaled microbes and viruses. In this proposal, we utilize mouse models and human samples to study how olfactory tissue defends itself and the body against infection and injury. The experiments will provide new insights into neuro-immune interactions in the olfactory system, which will potentially lead to new strategies for treating the loss of the sense of smell, which is a health problem that markedly diminishes the quality of life of affected individuals.

PI_NAMEs: LANE, ANDREW P (contact)

PROGRAM_OFFICER_NAME: SULLIVAN, SUSAN L

PROJECT_TERMS: 2019-nCoV;Address;Affect;airway epithelium;Anatomy;Anosmia;Apical;Basal Cell;Bipolar Neuron;Brain;Cell Communication;Cell Differentiation process;Cell Line;Cell Physiology;Cell Proliferation;cell type;Cells;Chemicals;chemokine;Chronic;cilium motility;Communication;COVID-19 pandemic;cytokine;differential expression;Environment;epithelial injury;Epithelium;experimental study;fighting;Foundations;Genes;Goals;Health;Human;Immune;immune cell infiltrate;immune function;Immune response;Immune signaling;Immune system;immunoregulation;Impairment;In Vitro;in vivo;Individual;Infection;Inflammation;Inflammatory;Inhalation;Injury;Innate Immune Response;Innovative Therapy;insight;Irritants;Knowledge;Location;Maintenance;Mediating;Mesenchymal;Microbe;Modeling;mouse model;Mucociliary Clearance;Mucous Membrane;Mus;Nasal Polyps;Natural regeneration;Nerve Regeneration;Neuroepithelial;neuroepithelium;Neuroimmune;Neuroimmunomodulation;Neurons;neuropeptide Y;Nose;notch protein;novel;Olfactory Epithelial Cell;Olfactory Epithelium;Olfactory Mucosa;Olfactory Pathways;Organ;pathogen;Pathway interactions;Pattern recognition receptor;Phagocytes;Physiological;Play;Process;progenitor;Pseudostratified Epithelium;Quality of life;Receptor Signaling;reconstitution;repaired;Research;Respiratory Mucosa;response;Rest;Role;Sampling;SARS-CoV-2 infection;scaffold;self-renewal;Sensory;Shapes;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Site;Smell Perception;stem cells;stemness;Stimulus;Structure;Surface;sustentacular cell;Testing;Tissues;trafficking;transcription factor;Transcriptional Regulation;transcriptome sequencing;transcriptomics;United States;Virus;Virus Diseases;Work

PROJECT_TITLE: Olfactory mucosa repair and defense: neuro-immune mechanisms and therapy

STUDY_SECTION: NIC

STUDY_SECTION_NAME: Neuroscience of Interoception and Chemosensation Study Section[NIC]


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Bioengineering;Building Research Capacity at Institutions with Limited NIH Funding;Diabetes;Networking and Information Technology R&D (NITRD);Nutrition;Patient Safety;Pediatric

ORG_CITY: SAN DIEGO

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: SAN DIEGO STATE UNIVERSITY

ORG_STATE: CA

PHR: PROJECT NARRATIVE Pediatric diabetes has been steadily increasing in recent decades by far greater rates than can be predicted by diet and lifestyle alone. This research utilizes computational modeling to characterize how exposures to pharmacological or toxicological agents during development can impair pancreatic organogenesis and potentially predispose individuals to diabetes later in the lifecourse. Here, we employ a rigorous multilayer network and topological clustering approach, rather than simple regression, to build predictive quantitative structure-activity relationship (QSAR) models and adverse outcome pathways (AOPs) with broader toxicological translation.

PI_NAMEs: GEORGE, UDUAK ZENAS (contact)

PROGRAM_OFFICER_NAME: SERRANO, KATRINA JANE

PROJECT_TERMS: adverse outcome;antagonist;Biological;biological systems;chemical property;Chemical Structure;Chemicals;Childhood diabetes;Complex;computational toxicology;Computer Analysis;Computer Models;Cross-Sectional Studies;cytotoxicity;Data Set;Development;developmental disease;developmental toxicity;developmental toxicology;Diabetes Mellitus;diabetic;Diet;diet and exercise;dietary;Disease;Embryo;Environmental Pollutants;Environmental Science;Etiology;Experimental Models;Exposure to;Gene Expression;Gene Targeting;Goals;Habits;Health;Heterogeneity;high dimensionality;Impairment;Incidence;Individual;Insulin-Dependent Diabetes Mellitus;Life Cycle Stages;Life Style;Mathematics;Metabolic Diseases;Methodology;Methods;Modeling;Molecular;Morphology;multi-scale modeling;network models;Non-Insulin-Dependent Diabetes Mellitus;novel;Organ;Organogenesis;Outcome;Pancreas;pancreas development;Pathogenesis;Pathologic;Pathway interactions;Peroxisome Proliferator-Activated Receptors;pharmacologic;physical science;PPAR alpha;predictive modeling;Prevalence;Process;Quantitative Structure-Activity Relationship;Receptor Signaling;Research;Resolution;response;Science;SEARCH for Diabetes in Youth;Signal Transduction;small molecule;spatiotemporal;Structure;Techniques;Testing;Tissues;Toxic effect;Toxicology;transcriptomics;translational impact;Translations;Uncertainty;Unhealthy Diet;United States;Youth;Zebrafish

PROJECT_TITLE: Integrating Computational and Experimental Models to Predict Toxicity of the Pancreas

STUDY_SECTION: MABS

STUDY_SECTION_NAME: Modeling and Analysis of Biological Systems Study Section[MABS]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Bioengineering;Brain Disorders;Cardiovascular;Clinical Research;Heart Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_DEPT: EMERGENCY MEDICINE

ORG_STATE: PA

PHR: Project Narrative Physicians’ struggle to accurately distinguish patients who will awaken from coma after cardiac arrest from those with irrecoverable injury. This proposal brings together a diverse team of world-class experts in post- arrest care, statistical modeling and machine learning to develop a tool that rapidly and accurately delivers prognostic information to doctors. Improving the speed and accuracy of post-arrest prognostication will save lives, allow appropriate resources to be directed to patients who are likely to benefit, avoid long and difficult care for patients who cannot recover, and spare families the agony of prolonged uncertainty.

PI_NAMEs: ELMER, JONATHAN  (contact)

PROGRAM_OFFICER_NAME: HEWETT, SANDRA JEANNE

PROJECT_TERMS: Academic Medical Centers;Address;analytical tool;Anoxic Encephalopathy;Benchmarking;Brain;Brain Injuries;Caring;Cause of Death;Clinical;Clinical Data;Collection;Coma;Complex;cost;Critical Care;Data;data ecosystem;Databases;Decision Support Systems;deep learning;demographics;Detection;disability;Electroencephalography;Ensure;Event;evidence based guidelines;Evolution;Failure;Family;feature selection;Future;Heart Arrest;Hospitalization;Hour;Human;Image;improved;inclusion criteria;Information Sciences;Injury;innovation;insight;Knowledge;Label;Laboratories;Learning;life-sustaining therapy;Machine Learning;Methods;Modality;model building;Modeling;Modern Medicine;Monitor;neural;Neurologic;Neurologic Examination;neurological recovery;novel;novel strategies;Outcome;outcome prediction;Output;Patient Care;patient population;Patient-Focused Outcomes;Patients;Pattern;Performance;Pharmaceutical Preparations;Physicians;Physiological;Physiology;predictive tools;Process;Prognosis;prognostic;prognostication;prospective;prospective test;Provider;random forest;Recommendation;Recovery;Resolution;Resources;risk minimization;Sampling;Series;Specificity;Speed;Statistical Models;Structure;Supervision;Survival Analysis;Survivors;System;Temperature;Test Result;Testing;Time;tool;Training;training data;Uncertainty;United States;Validation;Withdrawal;Work

PROJECT_TITLE: Optimizing Recovery prediction after Cardiac Arrest (ORCA)

STUDY_SECTION: CIDH

STUDY_SECTION_NAME: Clinical Informatics and Digital Health Study Section[CIDH]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Drug Abuse (NIDA only);Neurosciences;Nutrition;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: SAINT LOUIS

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative: In 2018, more than 60,000 people died from opioid overdose. The rapid escalation of opioid substance abuse that contributes to the development of addiction is, in part, driven by activation of endogenous opioid systems in nucleus accumbens, a brain area implicated in mediating the pleasurable and rewarding effects of natural and drug rewards (Koob and Volkow 2016; Richard et al. 2013). Therefore, the goal of this proposal is to refine and elucidate the mechanistic substrates of this opioid system in motivation.

PI_NAMEs: CASTRO, DANIEL CHARLES (contact)

PROGRAM_OFFICER_NAME: LIN, YU

PROJECT_TERMS: addiction;Affect;Affective;Animals;Area;Arrestins;Behavior;Behavioral;Behavioral Paradigm;beta-arrestin;Brain;Budgets;calcium indicator;Calcium Signaling;career;cell type;Cessation of life;Chimera organism;Classification;Committee Members;conditional knockout;Consumption;CRISPR/Cas technology;Development;dorsal raphe nucleus;drug reward;Eating;endogenous opioids;Enkephalins;Ensure;experimental study;Faculty;Fiber;Food;food consumption;Food deprivation (experimental);Genetic;genetic approach;Goals;GTP-Binding Proteins;hedonic;illicit opioid;Image;imaging approach;in vivo;in vivo imaging;Incentives;Intake;Interdisciplinary Study;interest;Intervention;Knockout Mice;Knowledge;knowledgebase;Lead;Leadership;Learning;light gated;loss of function;Measures;Medial;Mediating;meetings;Mentors;Mentorship;microendoscopy;Microscopy;Modeling;Molecular;motivated behavior;Motivation;mouse model;mu opioid receptors;Mus;Naloxone;Negative Valence;neural circuit;neurochemistry;neuromechanism;Neurons;novel strategies;novel therapeutics;Nucleus Accumbens;Opioid;opioid overdose;opioid use disorder;optogenetics;orofacial;Output;Pathway interactions;Persons;Pharmaceutical Preparations;pharmacologic;Pharmacology;Phase;Phosphorylation;Photometry;Photons;Physiological;Physiology;Population;Positioning Attribute;Positive Valence;Postdoctoral Fellow;postsynaptic;prescription opioid abuse;presynaptic;Presynaptic Terminals;prevent;programs;Prosencephalon;Proteins;Quinine;Reaction;receptor;receptor function;Receptor Signaling;recruit;Research;Research Personnel;response;Rewards;Rhodopsin;Role;Scientific Societies;Serine;Shapes;Signal Pathway;Signal Transduction;Signaling Protein;Site;skills;Structure;Substance abuse problem;Sucrose;symposium;System;Taste Perception;taste stimuli;Technical Expertise;Testing;Therapeutic;Thirst;Time;Training;training opportunity;United States;Viral;Viral Vector;Water

PROJECT_TITLE: Physiological and Molecular Mechanisms of Mu Opioid Receptors in Motivation and Affect


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Immunotherapy;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: PROVIDENCE

ORG_DEPT: PATHOLOGY

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: Project Narrative Modulation of the cellular composition of immunologically cold tumors such as glioblastoma (GBM) may be a useful approach for combination treatments alongside systemic immunotherapies. We have identified that delivery of chemically-modified derivatives of the Chinese traditional medicine component indirubin via a novel nanoparticle formulation promotes survival of GBM-bearing mice and alters tumor cellular composition. Here we will perform mechanistic and survival studies in mouse GBM models to provide support for new therapeutic approaches in GBM patients.

PI_NAMEs: LAWLER, SEAN EDWARD (contact)

PROGRAM_OFFICER_NAME: AGYIN, JOSEPH KOFI

PROJECT_TERMS: angiogenesis;Angiogenesis Inhibitors;Animals;Anti-Inflammatory Agents;Aryl Hydrocarbon Receptor;Biodistribution;Biological Availability;Biological Process;Brain Neoplasms;cancer therapy;cancer type;CD8-Positive T-Lymphocytes;Cell Line;Cells;Chemicals;chemoradiation;Chinese;Chinese Traditional Medicine;Chronic Myeloid Leukemia;clinical development;clinical translation;Clinical Trials;Coculture Techniques;Combination immunotherapy;Combined Modality Therapy;copolymer;Cytometry;Data;design;Development;Dose;Drug Kinetics;efficacy evaluation;Enzymes;Excision;experimental study;Formulation;Future;Glioblastoma;Goals;Heterogeneity;Human;Immune;immune checkpoint blockade;Immune system;Immunocompetent;Immunologics;Immunosuppression;Immunotherapeutic agent;Immunotherapy;improved;In Vitro;in vivo;indigo dye;indirubin;Infiltration;Interferons;Intracranial Neoplasms;Intravenous;intravenous administration;intravenous injection;Invaded;irradiation;kinase inhibitor;Kynurenine;Macrophage;Malignant neoplasm of brain;Malignant Neoplasms;Medical;Melanoma;Modeling;Molecular;Molecular Biology;mouse model;Mus;nanoparticle;nanopolymer;Natural Products;Nature;novel;novel therapeutic intervention;Operative Surgical Procedures;Pathway interactions;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;Phosphoproteins;Physiological;Plants;pre-clinical;pre-clinical assessment;preclinical study;Proliferating;Psoriasis;Publishing;rapid growth;Refractory;refractory cancer;response;Safety;Solubility;standard of care;success;Suspensions;Testing;Therapeutic;Toxic effect;transcriptome sequencing;translational therapeutics;Tryptophan;Tryptophan 2,3 Dioxygenase;tumor;tumor growth;Tumor Immunity;tumor microenvironment;Tumor Promotion;tumor-immune system interactions;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Preclinical assessment of efficacy and tumor microenvironment alterations by PPRX-1701 in glioblastoma


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Project Narrative Primary cilium is an important cellular organelle that senses and integrates cell signaling responses to environmental cues. Human ciliopathies comprise a wide spectrum of human diseases caused by ciliary defects. Due to major gaps in our knowledge about ciliary structure and signaling, the molecular bases of ciliary dysfunction in many ciliopathies remain obscure. Our proposal is aimed at elucidating the mechanisms underpinning cell signaling of a ciliopathy-associated protein kinase that has a highly conserved role in negative regulation of ciliogenesis and cilia length. Anticipated outcomes from this continuation proposal will significantly advance our understanding of the basic mechanisms underlying human ciliopathies.

PI_NAMEs: FU, ZHENG  (contact)

PROGRAM_OFFICER_NAME: XU, JIANHUA

PROJECT_TERMS: Address;Adenylate Cyclase;Affect;Animal Model;Apical;base;Binding;Body System;C-terminal;Cell model;Cell Physiology;Cell surface;Cells;Chemicals;Cilia;ciliopathy;cilium biogenesis;Clinical;Cues;Cyclic AMP;Cyclic AMP-Dependent Protein Kinases;Data;Defect;Development;Disease;DNA Sequence Alteration;Enzymes;Epilepsy;Esthesia;Event;Exhibits;Functional disorder;Genes;Genetic Diseases;Genetic Engineering;Growth Factor;Homeostasis;Human;human disease;Human Genetics;Impairment;in vivo;innovation;katanin;kinetosome;Knowledge;Length;Link;loss of function;Mammalian Cell;MAP Kinase Gene;Mediating;Microtubules;Molecular;Motility;Motor;Mus;mutant;Mutation;novel;null mutation;organ growth;Organelles;Outcome;Pathogenicity;Perinatal mortality demographics;Phenotype;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphotransferases;Play;Point Mutation;PP5 protein-serine-threonine phosphatase;Production;Protein Dephosphorylation;Protein Kinase;Protein-Serine-Threonine Kinases;Proteins;Regulation;Reporting;Research;Research Proposals;response;Role;Scaffolding Protein;Sensory;Signal Pathway;Signal Transduction;Site;smoothened signaling pathway;Structure;Surface;Testing;tissue-factor-pathway inhibitor 2;Tissues;Variant;Yin-Yang

PROJECT_TITLE: Signaling Mechanisms and Cellular Functions of a Ciliopathy-Associated Protein Kinase

STUDY_SECTION: MIST

STUDY_SECTION_NAME: Molecular and Integrative Signal Transduction Study Section[MIST]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Biotechnology;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Liver Disease;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Embryonic - Non-Human;Substance Misuse

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because understanding how elevated NADH contributes to non-alcoholic and alcoholic fatty liver disease will enable novel approaches to treat these conditions, which are the most common forms of liver disease in the United States but which have no effective pharmacologic therapies. Thus, the proposed project is relevant to the NIH’s mission to seek and apply knowledge to lengthen life and reduce illness.

PI_NAMEs: GOODMAN, RUSSELL PAUL (contact)

PROGRAM_OFFICER_NAME: PAWLIKOWSKA, LUDMILA SYLWIA

PROJECT_TERMS: Alcoholic Fatty Liver;Alcohols;Candidate Disease Gene;Cardiovascular Diseases;Cell Culture Techniques;circulating biomarkers;Cirrhosis;cofactor;cohort;Data;Dependence;Development;Disease;Dyslipidemias;Engineering;experimental study;Fatty acid glycerol esters;Fatty Liver;fatty liver disease;FGF21 gene;fibroblast growth factor 21;Genes;Genetic;Genetic Determinism;Genetic Transcription;genome wide association study;Genotype;Goals;heart metabolism;Hepatic;Human;Human Engineering;Human Genetics;Hydroxybutyrates;improved;in vivo;inhibitor;innovation;insight;Knowledge;Life;Lipids;Liver;Liver diseases;liver transplantation;Measures;Medical;Metabolic;metabolic abnormality assessment;Metabolic Diseases;Metabolic Pathway;Metabolic stress;Metabolism;Mission;Modeling;Morbidity - disease rate;mortality;mouse model;Mus;NADH;Nature;non-alcoholic fatty liver;non-alcoholic fatty liver disease;novel;novel strategies;novel therapeutic intervention;novel therapeutics;Organoids;Oxidation-Reduction;Pathogenicity;pharmacologic;Phenotype;pleiotropism;Post-Translational Protein Processing;Public Health;Publishing;Reaction;Research;Role;Source;Stress;Testing;Therapeutic;therapeutic target;Time;tool;trait;transcription factor;Transcriptional Activation;transcriptome sequencing;Transgenic Organisms;United States;United States National Institutes of Health;Variant;Work

PROJECT_TITLE: An NADH-ChREBP axis in fatty liver disease and dyslipidemia

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Clinical Research;Lung;Lung Cancer;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention

ORG_CITY: WORCESTER

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: Project Narrative The proposed research is relevant to public health because it represents a new and alternative strategy for detecting lung nodules that would have been otherwise missed. This project will show clear and reliable behavioral and physiological biomarkers of non-conscious detection at the location of missed lung nodules using high-speed eye-tracking. These eye-tracking biomarkers of non-conscious detection can be used to train Machine Learning modules to detect the location of missed nodule: disrupting the current standard in Radiology AI by reading the radiologist and not the image, making use of the full trained expertise of the radiologist by tapping into these non-conscious expert processes, and improving detection accuracy and subsequent cancer outcomes beyond that currently constrained by solely conscious recognition. Thus, the proposed research is relevant to the NCI's mission to reduce lung cancer and increase cancer survival rates.

PI_NAMEs: DIGIROLAMO, GREGORY JAMES (contact)

PROGRAM_OFFICER_NAME: GREEN, PAIGE A

PROJECT_TERMS: Anatomy;Arousal;Behavioral;Biological Markers;biomarker identification;biomedical imaging;Brain;Cancer Detection;cancer survival;Cessation of life;Chest;Classification;clinical practice;Complex;Conscious;Data;Detection;detection limit;Diagnosis;Diagnostic;Diagnostic Errors;Early Diagnosis;experience;Eye;Feedback;Image;improved;indexing;innovation;Learning Module;Left;Location;Lung;Lung nodule;Machine Learning;machine learning model;Malignant neoplasm of lung;Malignant Neoplasms;Measures;Medical Students;Mission;Modality;Modeling;Mus;Nodule;Normal tissue morphology;novel;Outcome;Patients;Physiological;Principal Investigator;Process;programs;Public Health;Pupil;radiologist;Radiology Specialty;random forest;Reading;Research;Specific qualifier value;Speed;Survival Rate;Testing;Time;Training;visual search;visual tracking;X-Ray Computed Tomography

PROJECT_TITLE: Increasing Nodule Detection in Lung Cancer by Non-Conscious Detection of "Missed" Nodules and Machine Learning


ADMINISTERING_IC: MH

ED_INST_TYPE: GRADUATE SCHOOLS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Mental Illness;Neurodegenerative;Neurosciences;Schizophrenia

ORG_CITY: Princeton

ORG_DEPT: NEUROSCIENCES

ORG_NAME: PRINCETON UNIVERSITY

ORG_STATE: NJ

PHR: PROJECT NARRATIVE This project will investigate how the brain uses rules to guide our behavior. Rules define how we should act in a given situation and so disrupting one’s ability to learn and follow rules carries significant social and economic costs for many neuropsychiatric and neurodegenerative diseases, including schizophrenia. Our work will provide insight into the neural mechanisms of rule-based behavior, providing the foundation for a better understanding of these diseases.

PI_NAMEs: BUSCHMAN, TIMOTHY J. (contact)

PROGRAM_OFFICER_NAME: ROSSI, ANDREW F

PROJECT_TERMS: Acute;Animals;Area;attentional control;autism spectrum disorder;Basal Ganglia;Bayesian Modeling;Behavior;Behavioral;Behavioral Paradigm;Belief;Brain;Chronic;Cognition Disorders;Cognitive;cognitive control;Cognitive deficits;Color;Complex;Computer Models;Corpus striatum structure;Dementia;Detection;Disease;Early Intervention;Eating;economic cost;Electric Stimulation;Electrodes;Electrophysiology (science);Evolution;experience;experimental study;Feedback;flexibility;Foundations;Functional Magnetic Resonance Imaging;improved;insight;Knowledge;Learning;Maintenance;Maps;Measures;Mental disorders;Mental Health;Modeling;Monkeys;Motor;Nature;neural;Neurodegenerative Disorders;neuromechanism;Neurons;neuropsychiatric disorder;novel;novel diagnostics;Obsessive-Compulsive Disorder;Parietal Lobe;Pathologic;Pattern;Physiological;Positioning Attribute;predictive modeling;Prefrontal Cortex;Research;response;Restaurants;Rewards;Role;Saccades;Schizophrenia;Sensory;sensory input;sensory stimulus;Shapes;Short-Term Memory;social;Stimulus;Structure;Techniques;Testing;theories;Training;Update;Work

PROJECT_TITLE: Neural Mechanisms of Rule-Based Behavior

STUDY_SECTION: LMDN

STUDY_SECTION_NAME: Learning, Memory and Decision Neuroscience Study Section[LMDN]


NIH_SPENDING_CATS: Brain Disorders;Neurosciences

ORG_CITY: TAMPA

ORG_DEPT: PHYSICS

ORG_NAME: UNIVERSITY OF SOUTH FLORIDA

ORG_STATE: FL

PI_NAMEs: ULLAH, GHANIM  (contact)

PROGRAM_OFFICER_NAME: LEENDERS, MIRIAM

PROJECT_TERMS: Affect;Astrocytes;Bioenergetics;Brain;Brain region;Cell Physiology;Cells;Cellular Morphology;Chemical Synapse;Communication;Computer Models;Data;density;design;Development;Disease;Dissection;driving force;Electrophysiology (science);Event;Excitatory Synapse;excitotoxicity;experimental study;extracellular;Extracellular Space;Feedback;Florida;fluorescence imaging;fluorescence lifetime imaging;Fluorescence Microscopy;Future;German population;Germany;Giant Cells;Glutamate Transporter;Glutamates;Heterogeneity;Hippocampus;Homeostasis;image processing;Impairment;Individual;insight;Ion Transport;Ischemic Stroke;Link;Measures;Modeling;Molecular;Monitor;Morphology;multi-scale modeling;multiphoton imaging;Mus;N-Methyl-D-Aspartate Receptors;Neocortex;neocortical;Nervous System Disorder;neuronal cell body;neuronal excitability;Neuronal Plasticity;Neurons;neurotransmission;novel;novel strategies;Pathway interactions;pharmacologic;Pharmacology;Play;postsynaptic;predictive modeling;Preparation;presynaptic;Process;Production;Property;Protons;Research;Research Proposals;Role;Side;Signal Transduction;Site;spatiotemporal;Specificity;stoichiometry;Structure;Synapses;Synaptic Cleft;synaptic function;Synaptic Transmission;Techniques;Testing;Time;Tissues;tool;transmission process;Universities;uptake;Viral;Work

PROJECT_TITLE: CRCNS US-German Research Proposal: Quantitative and Computational Dissection of Glutamatergic Crosstalk at Tripartite Synapses


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Colorectal Cancer;Digestive Diseases;Patient Safety;Radiation Oncology;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: OMAHA

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: PROJECT NARRATIVE Patients receiving radiotherapy for rectal cancers often suffer from debilitating side-effects due to radiation damage to tissues surrounding the tumor. Currently, there are no radioprotectors approved to be used with rectal cancer radiotherapy. An antioxidant drug, BMX-001, shows promise as an effective, clinical, radioprotector because the drug protects healthy tissues from radiation damage while, simultaneously, inhibiting growth of colorectal cancers.

PI_NAMEs: LIN, CHI ;OBERLEY-DEEGAN, REBECCA E (contact)

PROGRAM_OFFICER_NAME: VIKRAM, BHADRASAIN

PROJECT_TERMS: Acute;acute toxicity;Address;Adverse effects;American Cancer Society;Antioxidants;Anus;Apoptosis;Area;biomarker identification;Bladder;Blood;BMX gene;cancer cell;Cancer Patient;cancer radiation therapy;Cell Death Induction;Cell Proliferation;chemoradiation;chemotherapy;Chronic;Clinical;Colorectal;Colorectal Cancer;Combined Modality Therapy;cytotoxic;Data;Diagnosis;Disease-Free Survival;DNA Damage;efficacy evaluation;Epithelium;FDA approved;Fecal Incontinence;Fibrosis;Fluorouracil;Free Radicals;Functional disorder;gastrointestinal;Genitourinary system;Growth;Hematology;Hemorrhage;Histologic;Human;improved;in vivo Model;Inflammation;inflammatory marker;Injury;insight;Insurance;Intestinal permeability;Intestines;irradiation;Malignant neoplasm of anus;Malignant Neoplasms;Manganese;Mediating;Metabolic;Mucous Membrane;Neoadjuvant Therapy;Normal Cell;Normal tissue morphology;Operative Surgical Procedures;oxidative damage;Oxidative Stress;Paraffin Embedding;Pathway interactions;Patient-Focused Outcomes;Patients;Pelvis;pelvis fracture;Permeability;Pharmaceutical Preparations;Phase II Clinical Trials;phase II trial;Placebo Control;Porphyrins;Postoperative Complications;potential biomarker;prevent;primary endpoint;Production;Quality of life;Radiation;Radiation Dose Unit;Radiation exposure;Radiation induced damage;Radiation Monitoring;Radiation Protection;Radiation therapy;Radiation Toxicity;radiation-induced tissue damage;Randomized;Reactive Inhibition;Reactive Oxygen Species;Rectal Cancer;Rectum;Resected;Safety;Sampling;secondary endpoint;senescent cell;side effect;Signal Transduction;Skin;small molecule;SOD2 gene;Specimen;Stains;stem cell biomarkers;stem cells;Structure;Superoxides;Survival Rate;Therapeutic;Tight Junctions;tissue injury;Tissues;Toxic effect;Transforming Growth Factor beta;Translating;tumor;tumor growth;tumor progression;Urine;Work

PROJECT_TITLE: Use of radioprotector in rectal cancer

STUDY_SECTION: CONC

STUDY_SECTION_NAME: Clinical Oncology Study Section[CONC]


ADMINISTERING_IC: AG

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Palliative Care;Prevention

ORG_CITY: SAN FRANCISCO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Understanding the epidemiology of prescribing cascades and the patterns of decision-making that lead to them will help clinicians and health system leaders develop strategies to prevent and mitigate these often-harmful practices.

PI_NAMEs: STEINMAN, MICHAEL A. (contact)

PROGRAM_OFFICER_NAME: NOVAK, PRISCILLA JOY

PROJECT_TERMS: 5 Alpha-Reductase Inhibitor;Accidents;Address;Adrenergic alpha-Antagonists;Adverse drug effect;Adverse effects;Affect;Alzheimer's disease related dementia;Amiodarone;Bladder;Caring;Chronology;Clinical;combat;Communication difficulty;Complex;Control Groups;Data;Data Sources;Decision Making;Dementia;Disease;Diuretics;Edema;Elements;Epidemiology;Event;Frequencies;gabapentin;General Population;Goals;Health;Health system;Impaired cognition;indexing;Individual;Internet;Link;Medicare;men;Mentors;Methods;Mid-Career Clinical Scientist Award (K24);Modeling;Morbidity - disease rate;multiple chronic conditions;Nature;Neurofibrillary Tangles;older adult;Outcome;palliative;Pathway interactions;Pattern;Peripheral;Persons;Pharmaceutical Preparations;Polypharmacy;Population;Predisposition;pregabalin;Prevalence;prevent;Process;Public Health;Reporting;Research;Research Personnel;research study;Retinal blind spot;Retrospective cohort;Risk;Risk Factors;Scholarship;Side;Signs and Symptoms;Spasmolytics;symptom management;Symptoms;Thyroxine;Time;urinary

PROJECT_TITLE: Prescribing cascades in older adults with and without dementia

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Clinical Aging Study Section[NIA-C]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Dementia;Genetics;Neurodegenerative;Neurosciences;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: Los Angeles

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: NARRATIVE  The annual health care costs for neurodegenerative disorders range in excess of a hundred billion dollars. Sadly, we do not have cure yet for any of these diseases. Understanding cellular and molecular mechanisms underlying effects of apolipoprotein E (apoE) on the cerebrovascular system and how these effects may contribute to development of neuronal dysfunction and neurodegeneration, amyloid-beta and tau disorders will have profound implications for our understanding of Alzheimer’s disease pathogenesis and may ultimately guide the development of new therapeutic approaches for this devastating brain disorder.

PI_NAMEs: YASSINE, HUSSEIN N (contact)

PROGRAM_OFFICER_NAME: YIN, XILING

PROJECT_TERMS: Acceleration;adenovirus mediated delivery;Age;Alleles;Alzheimer's Disease;Alzheimer's disease risk;Amyloid beta-Protein;Apolipoprotein E;apolipoprotein E-3;apolipoprotein E-4;Apolipoproteins;APP-PS1;Astrocytes;behavior test;Blood - brain barrier anatomy;Blood capillaries;Blood flow;Blood Vessels;blood-brain barrier disruption;Brain;Brain Diseases;Brain Injuries;cell type;Cells;cerebral capillary;Cerebral endothelium;cerebrovascular;Cerebrovascular Disorders;Cerebrovascular system;Cyclophilin A;Data;Dementia;Dependovirus;Development;Disease;disorder control;Endothelium;Enterobacteria phage P1 Cre recombinase;Female;Functional disorder;Gelatinase B;Gender;Gene Delivery;Genes;genetic risk factor;Health Care Costs;Hemorrhage;in vivo;Intravenous;Knock-in;LDL-Receptor Related Protein 1;Link;Lipoprotein Receptor;LoxP-flanked allele;Magnetic Resonance Imaging;male;Mediating;Methods;Molecular;Mus;Nerve Degeneration;Neurodegenerative Disorders;neuron development;Neuronal Dysfunction;Neurons;neurovascular;novel;novel therapeutic intervention;Optical Methods;Pathogenesis;Pathogenicity;Pathology;Pathway interactions;Pericytes;Protein Isoforms;Proteins;Publishing;Signal Transduction;Smooth Muscle Myocytes;Structure;System;tau Proteins;Technology;Testing;Therapeutic;therapeutic target;Tissues;Vascular Smooth Muscle;vector

PROJECT_TITLE: Alzheimer's Abeta, Tau, Apolipoproteins and Blood-brain barrier

STUDY_SECTION: BINP

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: LA JOLLA

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

PHR: PROJECT NARRATIVE Autophagy is a recycling process with the ability to recruit selective type of cytosolic components like lipid droplets and protein aggregates for degradation. While accumulating evidence indicates that these selective types of autophagy play crucial roles in cellular health maintenance with application to age-related diseases such as Alzheimer’s disease, the regulatory functions of selective autophagy remain elusive. I will study the molecular mechanisms of lipophagy in the cells to further understand how lipophagy can be regulated during aging and neurodegeneration, using a small molecule approach.

PI_NAMEs: TAN, EE PHIE  (contact)

PROGRAM_OFFICER_NAME: DIBATTISTA, AMANDA

PROJECT_TERMS: 3-Dimensional;Acid Lipase;Address;Affect;age related;age-related disease;Aging;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease patient;Astrocytes;Autophagocytosis;Autophagosome;Autopsy;Binding;Binding Proteins;Brain;Caenorhabditis elegans;Candidate Disease Gene;cell injury;Cell model;Cell Physiology;Cells;Ceramides;Characteristics;Chronic Disease;combat;Deposition;design;Deterioration;Disease;Disease Progression;efficacy evaluation;Exhibits;extend lifespan;Failure;familial Alzheimer disease;fitness;functional restoration;Future;Genes;Genetic;Health;healthspan;high throughput screening;Homeostasis;Human;human disease;improved;Individual;insight;Intervention;knock-down;Knowledge;life span;Link;Lipids;Longevity;Lysosomes;Maintenance;Membrane;Methods;Modeling;Molecular;molecular phenotype;Molecular Profiling;Nematoda;Nerve Degeneration;Nervous System Disorder;Neurodegenerative Disorders;Neurons;novel;Organoids;Pathogenicity;Pathway interactions;pharmacologic;Phenotype;Play;preservation;Process;protein aggregation;Proteins;Proteomics;receptor;receptor function;recruit;Recycling;Research;Role;screening;small molecule;Therapeutic;Tissues;tool;Vesicle

PROJECT_TITLE: Role of selective autophagy in aging and neurodegeneration: a small molecule approach

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development Facilitating The Transition to Independence Study Section[AGCD-1]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Digestive Diseases;Immunotherapy;Inflammatory Bowel Disease

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Narrative Current IBD therapies often fail as a long-term treatment option and have undesirable side effects, leaving an unmet clinical need for new strategies that can sustain immune tolerance in IBD. The current proposal is aimed at understanding PD1 signaling in IBD patients, a major pathway implicated in peripheral immune tolerance, and leveraging these insights to maximize the efficacy of PD1 agonist monotherapy and low-dose IL-2 combination therapy in humanized IBD mouse models. The successful completion of this clinically-oriented proposal has the potential to advance novel therapies for IBD and other autoimmune disease patients.

PI_NAMEs: GOPAL, MURUGAIYAN  (contact)

PROGRAM_OFFICER_NAME: HUDSPETH, KELLY

PROJECT_TERMS: Address;Affect;Agonist;Alpha Interleukin 2 Receptor;Animal Model;Autoimmune Diseases;Autoimmunity;Autologous;Biological Models;CD34 gene;CD4 Positive T Lymphocytes;Cells;Chimeric Proteins;Clinical;clinically significant;Colitis;Combined Modality Therapy;Crohn's disease;cytokine;Dendritic Cells;Development;Disease;Dose;dysbiosis;effector T cell;Exploratory/Developmental Grant;Functional disorder;Goals;gut inflammation;Hematopoietic stem cells;high reward;high risk;Homeostasis;Human;humanized mouse;Immune;Immune response;Immune Tolerance;Immunocompromised Host;Immunoglobulins;immunoregulation;In Vitro;in vivo;Inflammation;Inflammatory;Inflammatory Bowel Diseases;innovation;insight;interest;Interleukin 2 Receptor;Interleukin-2;Interleukins;Intestines;Knock-in Mouse;Ligands;Modeling;mouse model;Mus;Myeloid Cells;novel therapeutic intervention;novel therapeutics;Pathogenesis;Pathogenicity;Pathway interactions;Patients;Peripheral;Peripheral Blood Mononuclear Cell;Persons;Prevalence;prevent;programmed cell death ligand 1;programmed cell death protein 1;Rag1 Mouse;Recombinants;reconstitution;Regulatory T-Lymphocyte;response;restraint;Role;side effect;Signal Transduction;single-cell RNA sequencing;T cell response;T cell therapy;T-Lymphocyte;Testing;Therapeutic;Therapeutic Effect;therapeutic target;Tissues;trinitrobenzene sulfonic acid induced colitis;Ulcerative Colitis

PROJECT_TITLE: Therapeutic targeting of PD1 signaling in inflammatory bowel disease

STUDY_SECTION: DHMI

STUDY_SECTION_NAME: Digestive System Host Defense, Microbial Interactions and Immune and Inflammatory Disease Study Section[DHMI]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Childhood Injury;Clinical Research;Neurosciences;Pediatric;Physical Injury - Accidents and Adverse Effects;Spinal Cord Injury;Traumatic Head and Spine Injury;Unintentional Childhood Injury

ORG_CITY: PHILADELPHIA

ORG_NAME: THOMAS JEFFERSON UNIVERSITY

PHR: Relevance to Public Health: The current clinical method to evaluate and classify neurological impairment of spinal cord injury (International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI)), causes anxiety in children up to eight years of age, is difficult to administer (invasive), and does not provide a direct assessment of damage to white matter tracts within the spinal cord. The creation of the first pediatric spinal cord structural template, which will be made available to the scientific community, will allow for examination of the spinal cord in a standardized space for group studies and can remove user variability during the analysis process. Also, if functional imaging measures such as DTI, DKI, NODDI, and SCCSA can be established as valid and reliable methods to quantify viable neural tissue within the spinal cord in young children, it will be a critical non invasive neurodiagnostic tool and a useful adjunct to the current ISNCSCI (The Standards).

PI_NAMEs: KRISA, LAURA ;MOHAMED, FEROZE B (contact)

PROGRAM_OFFICER_NAME: BAMBRICK, LINDA LOUISE

PROJECT_TERMS: 17 year old;3-Dimensional;8 year old;Age;American;Anatomy;Anxiety;Area;Atrophic;biological age;Biological Markers;biological sex;Cervical;Chest;Child;Childhood;Childhood Injury;Chronic;Classification;Clinical;clinical imaging;clinical predictors;Clinical Trials;Communities;Data;Data Set;density;Development;Diagnosis;Diffusion;Diffusion Magnetic Resonance Imaging;Disease;Esthesia;Functional Imaging;Future;Image;imaging biomarker;imaging modality;Imaging Techniques;Impairment;injured;Injury;International;Knowledge;Location;Magnetic Resonance Imaging;Measurement;Measures;Methods;Motor;Nature;neural;Neurites;neurodevelopment;neuroimaging;neuroimaging marker;Neurologic;neurological recovery;Neurological status;Patients;pediatric patients;Population;predictive modeling;Process;Public Health;quantitative imaging;Recovery;Reference Values;Research;Research Personnel;Resolution;Scanning;Sensitivity and Specificity;Severities;Spinal Cord;Spinal Cord Diseases;spinal cord imaging;Spinal cord injury;Spinal cord injury patients;Spinal Injuries;Standardization;structural imaging;Techniques;Tissues;tool;Treatment Effectiveness;Validation;white matter;Work

PROJECT_TITLE: Development of an MRI Template & Neuroimaging Biomarkers of the Pediatric Spinal Cord

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;HIV/AIDS;Immunization;Immunotherapy;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Antibodies have emerged as one of the most powerful and effective classes of drugs to treat a wide variety of human diseases including cancer, autoimmunity and inflammatory conditions. While much effort in the past has been devoted to engineering antibodies to recognize distinct targets, the next generation of antibodies will derive enhanced clinical efficacy from engineering efforts aimed at manipulating the manner in which antibodies engage immune receptors and the subsequent immune system reactions that they induce, which is driven nearly entirely by sugar molecules attached to the antibody. Experiments proposed in this application are designed to create a suite of uniquely glycosylated antibodies with customized effects on stimulating the immune system that could form the basis of a new generation of monoclonal antibody therapeutics.

PI_NAMEs: SUNDBERG, ERIC JOHN (contact)

PROGRAM_OFFICER_NAME: CASTLEMAN, MORIAH JOVITA

PROJECT_TERMS: Affinity;Antibodies;antibody engineering;antibody-dependent cell cytotoxicity;antigen binding;Antigens;Autoimmunity;Binding;Biochemical Reaction;Biological;Biophysics;cancer therapy;cell killing;Cells;Chemical Structure;Clinical;Clinical effectiveness;clinical efficacy;clinically relevant;Complement 1q;Complex;Complex Mixtures;design;Disease;Endoglycosidases;Endowment;Engineering;Equilibrium;Exhibits;experimental study;Fab domain;Fc domain;FDA approved;Fucose;Generations;glycosylation;human disease;IgG Receptors;IgG1;Immune signaling;Immune system;Immunoglobulin Constant Region;Immunoglobulin G;Immunologic Receptors;Immunologic Stimulation;Immunotherapeutic agent;in vivo;Infection;Inflammatory;innovation;Kinetics;Link;macromolecule;Malignant Neoplasms;Mannose;Measures;Mediating;Methods;Molecular;Monoclonal Antibodies;Nature;next generation;novel;Pharmaceutical Preparations;Pharmacotherapy;Polysaccharides;Property;Reaction;recruit;Research;Resolution;sialylation;structural biology;Structure;sugar;Therapeutic Monoclonal Antibodies;Thermodynamics;Time;Toxic effect;Treatment-related toxicity;Variant;Work

PROJECT_TITLE: Engineering mono-fucosylated IgGs to fine-tune antibody-mediated effector functions

STUDY_SECTION: CMIA

STUDY_SECTION_NAME: Cellular and Molecular Immunology - A Study Section[CMIA]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Cystic Fibrosis;Genetics;Infectious Diseases;Lung;Pediatric;Rare Diseases

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative Understanding the fundamental biology of bacterial phenotypic heterogeneity during infection will improve care success. Although Pseudomonas aeruginosa (Pa) is a leading cause of hospital acquired infections and chronic cystic fibrosis lung infections, there is a little information about why some Pa successfully transition from the environmental reservoirs to humans. This project aims to elucidate how cyclic-di-GMP metabolism and single cell variation alters the success of Pa during this important transition.

PI_NAMEs: MORRIS, ROXANNE  (contact)

PROGRAM_OFFICER_NAME: MOITRA, KAROBI

PROJECT_TERMS: Acute;Aerobic;Affect;antimicrobial;Bacteria;Behavior;Biology;Carbon;Caring;cell behavior;cell growth;Cells;Characteristics;Chronic;chronic infection;clinically relevant;cofactor;Cystic Fibrosis;cystic fibrosis airway;cystic fibrosis patients;Data;Development;diguanylate cyclase;Environment;environmental change;Enzymes;Exhibits;experience;fitness;follow-up;Gene Expression;Generations;Genetic Transcription;Growth;Heterogeneity;Human;improved;Individual;Infection;innovation;insight;Interruption;Knock-out;Libraries;Life Style;Literature;Lung infections;Measures;Metabolic;Metabolic Pathway;Metabolism;Methods;Microbial Biofilms;Microscopy;Modeling;Motility;Multi-Drug Resistance;mutant;Noise;Nosocomial Infections;novel strategies;Nucleotides;Nutrient;Nutrient availability;Nutritional;opportunistic pathogen;Outcome;Oxygen;pathogen;Pathway interactions;Patients;Periodicity;Persons;Phenotype;phosphoric diester hydrolase;Physiology;Play;Population;Pseudomonas aeruginosa;Pulmonary Cystic Fibrosis;Regulatory Pathway;Reporter;Reporting;response;Role;Second Messenger Systems;Source;success;Surface;Techniques;Testing;Time;time use;transcriptome;Translating;Translations;Variant;Virulence;Virulence Factors

PROJECT_TITLE: Determining the role of cyclic-di-GMP in Pseudomonas aeruginosa's transition to the nutritional environment of the cystic fibrosis lung

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F07C-K(20)]


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Hepatitis;Hepatitis - B;Infectious Diseases;Liver Disease

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

PHR: PROJECT NARRATIVE Hepatitis B virus (HBV) is an important human pathogen. There are approximately 300 million people in the world that are chronically infected by this virus, resulting in nearly 1 million deaths every year. The goal of our proposed research is to understand how HBV establishes persistent infection. The knowledge gained from our studies will be important for improving the treatments for chronic HBV patients.

PI_NAMEs: OU, J.-H. JAMES  (contact)

PROGRAM_OFFICER_NAME: FLORES, AMANDA CHRISTINE

PROJECT_TERMS: Affect;analog;anti-hepatitis B;Anti-Inflammatory Agents;attenuation;Binding;Birth;CD8-Positive T-Lymphocytes;Cell Separation;Cessation of life;Chronic;Chronic Hepatitis B;chronic infection;Cirrhosis;Clinical;Discipline of Nursing;e Antigens;Female;Genes;Genomic DNA;Glutamates;Glutaminase;Glycolysis;Goals;Grant;Hepatic;Hepatitis B e Antigens;Hepatitis B Therapy;Hepatitis B Virus;Hepatocyte;human pathogen;Impairment;improved;in utero;Inflammatory;Injections;Knowledge;Kupffer Cells;Length;Life;Liver;Liver diseases;Macrophage;male;Mediating;Metabolic;metabolic profile;Metabolism;metabolomics;Modeling;Mothers;mouse model;Mus;Names;offspring;Oxidative Phosphorylation;Patients;Persons;Play;Pregnancy;Primary carcinoma of the liver cells;Productivity;programs;Proteins;receptor;Regulation;Research;response;Role;Signal Pathway;T cell response;Testing;TLR4 gene;Training;Transgenic Mice;Viral;viral DNA;Viral Genome;Virus;Virus Replication

PROJECT_TITLE: Hepatitis B virus e antigen in viral persistence

STUDY_SECTION: VIRB

STUDY_SECTION_NAME: Virology - B Study Section[VIRB]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases;Rare Diseases;Tuberculosis

ORG_CITY: SEATTLE

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

ORG_STATE: WA

PHR: NARRATIVE Phosphosignaling is the primary means by which bacteria sense their environment and is thus critical for bacterial pathogenesis. This study will identify new phosphosignaling pathways in Mycobacterium tuberculosis, the causative agent of tuberculosis.

PI_NAMEs: GRUNDNER, CHRISTOPH  (contact)

PROGRAM_OFFICER_NAME: ROBINSON, RICHARD THOMAS

PROJECT_TERMS: Affect;Arginine;Bacillus subtilis;Bacteria;Biology;Chromosomes;Data;DNA Binding;endopeptidase Clp;Environment;Eukaryota;Event;Family;gain of function;Gene Expression;Genes;Genetic Transcription;Gram-Positive Bacteria;Individual;loss of function;Maps;Mass Spectrum Analysis;Measures;Mediating;mimetics;Modification;mutant;Mutation;Mycobacterium tuberculosis;novel;Organism;Output;Pathogenesis;Pathway interactions;Phenotype;phosphoproteomics;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphorylation Site;Phosphotransferases;Physiological;Post-Translational Protein Processing;preservation;protein degradation;Proteins;Proteolysis;Regulation;Role;Signal Pathway;Signal Transduction;Substrate Interaction;System;Testing;transcription factor;Transcriptional Regulation;transcriptomics;Tuberculosis;Virulence;Virulence Factors

PROJECT_TITLE: Functional exploration of a deep Mycobacterium tuberculosis phosphoproteome

STUDY_SECTION: PCMB

STUDY_SECTION_NAME: Prokaryotic Cell and Molecular Biology Study Section[PCMB]


NIH_SPENDING_CATS: Mental Health;Neurosciences

ORG_DEPT: BIOLOGY

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

PHR: Project Narrative Neurons are able to restore their activity when challenged by external or internal perturbations. This form of homeostatic plasticity is important in the maintenance of neuronal or network stability during development and normal brain function. The proposed research will investigate mechanisms regarding the biogenesis of calcium-permeable AMPA receptors during neuronal inactivity and the requirement of receptor acetylation for the expression of the homeostatic response.

PI_NAMEs: MAN, HENGYE  (contact)

PROGRAM_OFFICER_NAME: DRISCOLL, JAMIE DANIELLE

PROJECT_TERMS: Acetylation;Adenosine;adenosine deaminase;AMPA Receptors;Arginine;Biogenesis;Brain;Calcium;Calcium-Sensing Receptors;Chronic;Codon Nucleotides;Complex;dark rearing;deprivation;Development;DRADA2b protein;Enzymes;Generations;Glutamates;Glutamine;In Vitro;in vivo;Induced Neurons;Inosine;Link;Location;Maintenance;Mediating;Messenger RNA;Modification;Molecular;Mus;Nature;Neurons;novel;overexpression;Pathologic;Permeability;Pilot Projects;Play;posttranscriptional;Process;Protein Acetylation;Protocols documentation;receptor;Receptor Signaling;Regulation;Research;Resistance;response;Rodent Model;Role;Signaling Molecule;Site;Sodium;Synapses;Synaptic plasticity;Synaptic Receptors;Synaptic Transmission;Time;Visual Cortex;visual deprivation;Work

PROJECT_TITLE: Molecular mechanisms of homeostatic synaptic plasticity

STUDY_SECTION: NC

STUDY_SECTION_NAME: Neuronal Communications Study Section[NC]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: HIV/AIDS;Immunization;Infectious Diseases;Lymphatic Research;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: ITHACA

ORG_NAME: CORNELL UNIVERSITY

ORG_STATE: NY

PHR: Project Narrative The priming of CD8+ T cells by antigen presenting cells in the lymph node ultimately determines the success of the host response to intracellular pathogens. This grant aims to uncover a new paradigm for how immune development alters the position and behavior of CD8+ T cells in the lymph node.

PI_NAMEs: RUDD, BRIAN DAVID (contact);XU, CHRIS

PROGRAM_OFFICER_NAME: PRABHUDAS, MERCY R

PROJECT_TERMS: Adopted;Adult;Antigen-Presenting Cells;Antigens;Behavior;Bone Marrow;CD8-Positive T-Lymphocytes;cell behavior;Cell Communication;Cell Compartmentation;Cells;Collaborations;Cues;CXCR3 gene;Data;Dendritic Cells;Development;Disparate;Environment;Exhibits;fetal;Fetal Liver;fetus cell;Frequencies;Grant;Hematopoietic stem cells;Image;Image-Guided Surgery;Imaging Device;Immune;Immune response;Immune system;Immunological Models;Immunology;Individual;Infection;Inflammation;intravital imaging;Kinetics;Life;Link;Location;lymph nodes;lymphoid organ;Macrophage;Maps;mature animal;Measures;Memory;Metabolic;Microscopy;Mus;novel;pathogen;Photons;Positioning Attribute;Primary Infection;real-time images;recruit;Resolution;response;Role;secondary infection;Secondary to;stem cell population;success;Surveys;System;T cell response;T memory cell;T-Cell Activation;T-Lymphocyte;Testing;Time;tool;Vaccinia virus;Work

PROJECT_TITLE: Developmental layers of CD8+ T cells in the lymph node

STUDY_SECTION: CMIB

STUDY_SECTION_NAME: Cellular and Molecular Immunology - B Study Section[CMIB]


NIH_SPENDING_CATS: Genetics;Immunotherapy;Infectious Diseases;Malaria;Rare Diseases;Vector-Borne Diseases

ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: PROJECT NARRATIVE Plasmodium infections cause more than 400 million cases of malaria each year and more than 3.5 billion people are at risk for contracting this devastating infectious disease. The goal of our research is to identify and develop new immune-based interventions that improve the function of cells that are critical for resistance to blood-stage Plasmodium infection. These studies will enable us to enhance immunity against malaria.

PI_NAMEs: BUTLER, NOAH SULLIVAN (contact)

PROGRAM_OFFICER_NAME: PESCE, JOHN T

PROJECT_TERMS: Acute;adaptive immunity;Address;Agonist;Amino Acid Transporter;Anti-malarials;Antibody Response;Antigen-Presenting Cells;Applied Genetics;B-Lymphocytes;Biological;Biology;Blood;burden of illness;CD4 Positive T Lymphocytes;Cell Compartmentation;cell mediated immune response;Cell Physiology;Cells;Cessation of life;Communicable Diseases;Contracts;Data;Deposition;Development;Disease;drinking water;Erythrocytes;Event;Failure;functional improvement;Gene Expression Profile;genetic approach;Genetic Transcription;global health emergency;Glutamine;Goals;Helper-Inducer T-Lymphocyte;Hemoglobin;hemozoin;Humoral Immunities;Hypoxia;Immune;Immune response;Immunity;Immunology;immunoregulation;Immunotherapy;Individual;Infection;Inflammasome;Inflammation;innovation;Intervention;Journals;Knowledge;Link;Malaria;Mediating;Medicine;Metabolic;Metabolism;Molecular;Molecular Genetics;Mus;Natural Immunity;Nature;new therapeutic target;novel;novel strategies;Parasite Control;Parasites;Parasitology;pathogen;Pathogenesis;Pathway interactions;Physiological;Plasmablast;Plasmodium;Population;Populations at Risk;Predisposition;programs;Publications;Publishing;Reagent;Regulation;Reporting;Research;Resistance;Resolution;response;Severity of illness;Signal Transduction;Symptoms;System;T cell differentiation;T cell response;T-Cell Development;T-Lymphocyte Subsets;Testing;transcriptomics;Vaccines

PROJECT_TITLE: Regulation of Plasmodium-specific CD4+ T cells

STUDY_SECTION: IHD

STUDY_SECTION_NAME: Immunity and Host Defense Study Section[IHD]


NIH_SPENDING_CATS: Aging;Atherosclerosis;Cardiovascular

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: NARRATIVE Regulatory T cells have been shown to play important protective roles in atherosclerosis, including being critical for plaque regression. It is known that the atherosclerotic environment dysregulates regulatory T cells making them more inflammatory. This proposal hypothesizes that oxidized phospholipids that accumulate in plaques are mechanistically important for the dysregulation of regulatory T cells in atherosclerosis.

PI_NAMEs: MAJOR, AMY S (contact)

PROGRAM_OFFICER_NAME: JIANG, CHAO

PROJECT_TERMS: adaptive immunity;Affect;Animal Model;Arterial Fatty Streak;Arteries;atherogenesis;Atherosclerosis;C57BL/6 Mouse;Cardiac;Cardiovascular Diseases;Cause of Death;CD36 gene;CD4 Positive T Lymphocytes;Cell Compartmentation;Cell Count;cell dedifferentiation;Cell Fraction;Cell Physiology;Cell Survival;Cells;Cellular biology;Cholesterol;Clinical;cytokine;Data;Disease Outcome;effector T cell;Endothelial Cells;Environment;Event;experimental study;Feedback;FOXP3 gene;Functional disorder;Funding Mechanisms;Future;Growth;Human;Hyperlipidemia;Immune;In Vitro;in vivo;Inflammatory;insight;Interferons;Intervention;Knockout Mice;Laboratories;Lesion;lipid metabolism;Lipids;Macrophage;Measures;Mediating;mouse model;Myocardial Infarction;Nature;novel;oxidized low density lipoprotein;oxidized phosphatidyl choline;Pathogenicity;Patients;Phenotype;Phospholipids;Play;Population;Process;Production;Proteins;receptor;Receptor Signaling;Regulatory T-Lymphocyte;Research;response;Role;Rupture;scavenger receptor;Signal Transduction;single-cell RNA sequencing;T cell differentiation;T-bet protein;T-Lymphocyte;Testing;TLR4 gene;tumor microenvironment;United States;uptake;Work

PROJECT_TITLE: Investigating mechanisms of oxidized phospholipid-mediated dysregulation of regulatory T cells in atherosclerosis

STUDY_SECTION: AVI

STUDY_SECTION_NAME: Atherosclerosis and Vascular Inflammation Study Section[AVI]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Rehabilitation;Rural Health

ORG_CITY: LUBBOCK

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: TEXAS TECH UNIVERSITY HEALTH SCIS CENTER

ORG_STATE: TX

PHR: Project Narratives A substantially large number of children who need speech and language services are currently underserved in the US. Telepractice, the provision of speech-language services using communication technologies, has been considered as a way to enhance provision of speech-language services. The proposed study will develop a robust clinical intervention program, and test the efficacy of speech intervention via telepractice for children with a history of cleft palate using a randomized controlled trial design.

PI_NAMEs: LEE, SUE ANN SOYOUNG (contact)

PROGRAM_OFFICER_NAME: MATTIA, JILL

PROJECT_TERMS: Acoustics;Adopted;Affect;Agreement;Articulation;Auditory;Behavior;Behavior Therapy;Behavioral;Certification;Characteristics;Child;Cleft Palate;Clinical;Clinical Trials;clinically significant;Communication;Computer software;COVID-19 pandemic;craniofacial disorder;Custom;Data;Data Management Resources;Development;Disabled Children;Education;effectiveness evaluation;efficacy research;efficacy study;efficacy testing;Emotional;emotional factor;Ensure;Evaluation;evidence base;executive function;experimental study;functional outcomes;Genetic Transcription;glottis;Goals;health care service;Healthcare;Image;improved;Individual;Individuals with Disabilities Education Act;Inequity;innovation;instrumentation;Intervention;intervention program;Intervention Studies;Judgment;Language;language impairment;Literature;Manuals;Measures;Methodology;Methods;Mission;Modeling;Monitor;Mouth Diseases;National Institute of Dental and Craniofacial Research;non-verbal;operation;Output;Parents;Pathologist;Patients;Pattern;Perception;Pharyngeal structure;Phase;Phonetics;Physiological;Population;Prediction of Response to Therapy;Process;Production;programs;Protocols documentation;public education;Randomized, Controlled Trials;Recording of previous events;repaired;Reporting;Research;rural area;Safety;Sample Size;School Teachers;School-Age Population;Schools;Self-control as a personality trait;service delivery;Service delivery model;Services;Severities;skills;social;Social Distance;social interventions;software development;Speech;Speech and language services;Speech Disorders;Speech Perception;Stimulus;Strategic Planning;Technology;Testing;Therapeutic;treatment effect;Treatment Efficacy;Treatment outcome;Treatment Protocols;trial comparing;trial design;trial planning;U-Series Cooperative Agreements;United States;United States National Institutes of Health;urban area

PROJECT_TITLE: Speech Intervention via Telepractice for Children with Repaired Cleft Palate : Randomized Controlled Trial and Assessment of Speech Production and Perception Skills


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Rare Diseases;Tuberculosis

ORG_CITY: NEW YORK

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Project Narrative  Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), is one of the deadliest pathogens on the planet, and TB is one of the leading causes of death due to infectious disease. The cell envelope of Mtb forms a barrier around the cell, protecting the bacterium from antibiotics and our immune system. We will study protein-based systems that facilitate the transport of nutrients across the cell envelope, including the building blocks of the barrier itself, which may aid in the design of new antibiotics to treat TB.

PI_NAMEs: BHABHA, GIRA  (contact);EKIERT, DAMIAN CHARLES

PROJECT_TERMS: Antibiotics;Architecture;Bacteria;Binding;Biochemical;Biological Assay;Cause of Death;cell envelope;Cells;Cellular Membrane;Cholesterol;combat;Communicable Diseases;Complex;Complex Analysis;Cryoelectron Microscopy;design;Development;Drug resistance;Environment;Escherichia coli;Fatty Acids;gene product;Genes;Genus Mycobacterium;Gram-Negative Bacteria;Growth;Hydrophobicity;Immune response;Immune system;In Vitro;Individual;insight;Learning;Link;lipid transport;Lipids;Lung;Macrophage;Maintenance;Mammalian Cell;Mass Spectrum Analysis;Membrane;membrane biogenesis;Modeling;Multiprotein Complexes;Mutation;mycobacterial;Mycobacterium smegmatis;Mycobacterium tuberculosis;Nutrient;Operon;particle;pathogen;Pathogenesis;Phagosomes;Planets;Play;polypeptide;protein complex;Protein Family;protein function;protein protein interaction;protein structure;Protein Subunits;protein transport;Proteins;Proteomics;resistant strain;Role;structural biology;Structure;System;Testing;Time;trafficking;Tuberculosis;tuberculosis treatment;Virulence;Virulence Factors;Work

PROJECT_TITLE: Structural characterization of MCE transport systems from Mycobacterium tuberculosis


NIH_SPENDING_CATS: Clinical Research;Genetics;Infectious Diseases;Malaria;Rare Diseases;Vector-Borne Diseases

ORG_CITY: BALTIMORE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: PUBLIC HEALTH RELEVANCE As programmatic and research efforts shift from malaria control to malaria elimination, understanding host, parasite and environmental factors that contribute to parasite investment in sexual reproduction versus asexual replication will be critical for predicting the impact of new interventions on malaria transmission. In this study, we will examine the effect of host, parasite, and environmental factors on P. falciparum sexual commitment and gametocytemia in the context of a longitudinal cohort study, with particular emphasis on the impact of infection complexity and clone composition on gametocyte production by a given clone. In addition to providing important insights into parasite biology, we anticipate that this research will provide actionable associations to predict transmission reservoirs and identify target populations for transmission-reducing interventions.

PI_NAMEs: HARRISON, SHANNON TAKALA (contact)

PROGRAM_OFFICER_NAME: RAO, MALLA R

PROJECT_TERMS: Adult;Age;Anopheles Genus;Anti-malarials;Area;asexual;Biology;Bite;Blood;Bone Marrow;Child;Circulation;Clinical Treatment;cohort;Culicidae;density;Development;Disease;DNA;DNA-Binding Proteins;Dryness;enhancer-binding protein AP-2;Environmental Risk Factor;Epidemiology;Epigenetic Process;Equilibrium;Erythrocytes;Evaluation;Family;Female;follow-up;Frequencies;Genes;Genetic;Genotype;heterochromatin-specific nonhistone chromosomal protein HP-1;Human;Immunity;Individual;Infection;Ingestion;insight;Integration Host Factors;Interruption;Intervention;Invaded;Investments;Longitudinal cohort;Longitudinal cohort study;Malaria;malaria transmission;Malawi;male;Midgut;Molecular;Parasites;Participant;Peripheral;Plasmodium;Plasmodium falciparum;Production;Proteins;Public Health;public health relevance;Research;response;RNA;Sampling;School-Age Population;Seasons;Sex Differentiation;Sexual Development;Sexual Reproduction;Stream;Symptoms;Target Populations;theories;transmission blocking;transmission process;transmission-blocking vaccine;Vaccines;vector;vector mosquito

PROJECT_TITLE: Impact of infection complexity on P. falciparum sexual commitment and gametocytemia

STUDY_SECTION: GVE

STUDY_SECTION_NAME: Genetic Variation and Evolution Study Section[GVE]


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Crohn's Disease;Digestive Diseases;Genetics;Human Genome;Inflammatory Bowel Disease;Microbiome

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Up to 30% of patients with treatment refractory ulcerative colitis (UC) require colon removal and the creation of an ileal pouch anal anastomosis (IPAA) to serve as an internal pelvic stool reservoir and allow for defecation per anus. Approximately 20% of patients with an IPAA develop Crohn’s disease-like pouch inflammation (CDLPI) which causes symptoms similar to their original UC, and up to 50% of these patients do not respond to therapy and require surgical pouch removal and the creation of a permanent ostomy. We aim to characterize the genetic variants, ileal transcriptome, microbial and metabolomic profiles associated with CDLPI in patients with UC after IPAA in order to identify predictive disease markers and potential therapeutic strategies.

PI_NAMEs: KAYAL, MAIA  (contact)

PROGRAM_OFFICER_NAME: SASLOWSKY, DAVID E

PROJECT_TERMS: 16S ribosomal RNA sequencing;Affect;American;Anastomosis - action;Antibiotics;Anus;Anxiety;Automobile Driving;biobank;Biological;career;Childhood;Chronic;Clinical;clinical application;clinical care;cohort;Cohort Analysis;Colectomy;Colitis;Colon;Country;Crohn's disease;Data;Defecation;Development;Diagnostic;differential expression;Disease;Disease Marker;disease model;Distal;Environment;Evolution;Excision;experience;Exposure to;Faculty;Failure;Faith;Feces;Formalin;Funding;Gastroenterology;Gastrointestinal tract structure;Genes;Genetic;Genetic Anticipation;Genetic Risk;genetic variant;Genome;genome sciences;genomic locus;genotyped patients;Goals;Grant;gut inflammation;Histologic;Hospitals;host microbiome;Ileal Reservoirs;ileum;Inflammation;Inflammatory Bowel Diseases;innovation;Intention;Intestines;Link;Longitudinal cohort;Medical;medical schools;Medicine;Mental Depression;Mentorship;metabolome;metabolomics;Methodology;microbial;microbiome;microbiome analysis;microbiota;mid-career faculty;Modeling;multidisciplinary;Nature;news;Operative Surgical Procedures;Ostomy;Paraffin Embedding;pathobiont;Pathway interactions;patient oriented;Patients;Pediatrics;Pelvis;personalized medicine;Play;pre-clinical;preservation;prevent;Procedures;professor;profiles in patients;prognostication;prospective;psychosocial outcome;Rectum;Refractory;Reporting;Research;Research Personnel;restoration;Restorative Proctocolectomy;Risk;risk stratification;Role;Secondary to;skill acquisition;skills;Stomas;stool sample;Symptoms;Testing;Therapeutic;therapeutic target;Time;Tissue Sample;Training;transcriptome;transcriptome sequencing;transcriptomics;translational genetics;translational scientist;Ulcerative Colitis;Uncertainty;United States National Institutes of Health;Work

PROJECT_TITLE: Characterizing the Biologic Evolution of Crohn's Disease Like Pouch Inflammation in Ulcerative Colitis Patients After Restorative Proctocolectomy with Ileal Pouch Anal Anastomosis

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: American Indian or Alaska Native;Building Research Capacity at Institutions with Limited NIH Funding;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research

ORG_CITY: TUCSON

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: PROJECT NARRATIVE Environmental Health Science Research for Indigenous Scholar Engagement (EHS-RISE) is a summer training program for undergraduate Native American students at the University of Arizona. The long-term goal of EHS-RISE is to increase the number of Native Americans who chose careers in science. By contributing to workforce diversity, this project advances scientific innovation via the inclusion of a wide range of under- represented backgrounds and perspectives in problem-solving.

PI_NAMEs: SOLOMON, TESHIA G. ARAMBULA;ZHANG, QING-YU  (contact)

PROGRAM_OFFICER_NAME: HUMBLE, MICHAEL C

PROJECT_TERMS: academic standard;Address;Adopted;American Indians;Arizona;Attitude;Biology;career;cohort;college;Communities;community building;Creativeness;cultural values;Decision Making;design;Development;Diverse Workforce;diversity and inclusion;Education;Educational workshop;Environment;Environmental Health;Epistemology;Event;experience;Fostering;Goals;health science research;higher education;implicit bias;Indigenous;Individual;innovation;interest;Internships;Knowledge;learning community;matriculation;member;Modeling;National Institute of Environmental Health Sciences;Native Americans;Personal Satisfaction;Pharmacology and Toxicology;Positioning Attribute;Problem Solving;programs;recruit;Research;Research Activity;Research Project Grants;Research Training;role model;Science;Science, Technology, Engineering and Mathematics Education;Scientific Advances and Accomplishments;Scientist;Secure;skill acquisition;skills;STEM career;STEM field;STEM program;Student recruitment;Students;success;summer research;System;Toxicology;Training;Training Programs;undergraduate research experience;undergraduate student;Universities;university student

PROJECT_TITLE: Environmental Health Sciences Research for Indigenous Scholar Engagement (EHS-RISE)


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Depression;Mental Health;Neurosciences;Pain Research;Rehabilitation;Social Determinants of Health;Temporomandibular Muscle/Joint Disorder (TMJD)

ORG_CITY: FARMINGTON

ORG_NAME: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT

PHR: TMD-related pain is a widespread chronic pain problem, affecting not just the patient, but the family and the healthcare system at large. A treatment program that helps the patient more effectively develop coping skills can create the conditions necessary for long-term treatment success. Results from this project are expected to shed light on mechanisms of pain treatment and to translate to other chronic pain problems.

PI_NAMEs: LITT, MARK D. (contact)

PROJECT_TERMS: Accounting;Address;Adult;Affect;Aftercare;Behavioral;Chronic;chronic pain;chronic painful condition;chronic widespread pain;Cognition;Cognitive;Cognitive Therapy;coping;Coping Behavior;Coping Skills;Data;depressive symptoms;design;Development;Disease;Educational process of instructing;effective therapy;Effectiveness;Exhibits;experience;Family;Feeling;Frequencies;Goals;Healthcare Systems;Home environment;improved;in vivo;Individual;individualized medicine;information gathering;innovation;Life Style;Measurement;Measures;Mediating;Modeling;Monitor;Moods;Orofacial Pain;Outcome;Pain;Pain Disorder;Pain management;Pain Measurement;pain patient;pain symptom;Patients;personalized approach;Persons;Procedures;programs;psychosocial;Quality of life;Randomized;Records;recruit;Relaxation;Reporting;Role;Sampling;Self Efficacy;skill acquisition;skills;skills training;smartphone application;Splint Device;standard care;success;Temporomandibular Joint Disorders;Testing;Thinking;Time;Training;Translating;treatment effect;Treatment outcome;treatment program;Work

PROJECT_TITLE: Individualized Assessment and Treatment Program for TMD: Coping as a Mechanism

STUDY_SECTION: BMIO

STUDY_SECTION_NAME: Behavioral Medicine, Interventions and Outcomes Study Section[BMIO]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: PROJECT NARRATIVE  In vitro modeling of human disease has recently become possible due to the remarkable achievements of human induced pluripotent stem cells (iPSCs) and precise genome editing technologies. We propose to apply hereditary retinoblastoma (RB) iPSCs to dissect the pathological mechanisms triggered by RB1 mutation. This research will have the potential to reveal novel therapeutic targets to treat RB1-mutant osteosarcoma.

PI_NAMEs: LEE, DUNG-FANG  (contact)

PROGRAM_OFFICER_NAME: MAAS, STEFAN

PROJECT_TERMS: Achievement;Adolescence;Adolescent;Affect;Alternative Splicing;anti-cancer research;autosome;Binding;Biological Markers;Biological Models;bone;Brain Neoplasms;Cancer Etiology;cancer genetics;Cells;chemotherapy;Child;ChIP-seq;Clinical;clinical application;CRISPR/Cas technology;CUL9 gene;Data;Detection;Development;Disease;disease model;disorder control;Down-Regulation;Etiology;exome sequencing;experimental study;Fibroblasts;Future;Gene Expression;Genes;Genetic;Genome;genome-wide analysis;Germ-Line Mutation;Goals;Hereditary Retinoblastoma;Histologic;Human;human disease;human induced pluripotent stem cells;human model;Impairment;improved;in vitro Model;Incidence;Individual;induced pluripotent stem cell;Inherited;inhibitor;insight;Knockout Mice;leukemia;Li-Fraumeni Syndrome;Link;Lung;Malignant Bone Neoplasm;Malignant Childhood Neoplasm;Malignant Neoplasms;Mediating;Methodology;Missense Mutation;Modeling;Molecular;mortality;multicatalytic endopeptidase complex;Mus;mutant;Mutation;new therapeutic target;Non-Hematologic Malignancy;Nonmetastatic;novel;novel therapeutic intervention;Operative Surgical Procedures;Osteoblasts;Osteosarcoma;Pathologic;Pathway interactions;patient derived induced pluripotent stem cells;Patients;Pharmaceutical Preparations;pharmacologic;Phenocopy;precise genome editing;prevent;promoter;Proteins;Proteolysis;RB1 gene;Research;Research Personnel;Retinoblastoma;RNA Splicing;Role;Specimen;Spliceosomes;Survival Rate;System;Technology;Testing;Therapeutic;TP53 gene;transcriptome;tumor initiation;Tumor Suppressor Genes;Tumor Suppressor Proteins;Ubiquitin;ubiquitin-protein ligase;Variant

PROJECT_TITLE: Dissecting and Targeting RB1-Mutant Osteosarcoma

STUDY_SECTION: SBDD

STUDY_SECTION_NAME: Skeletal Biology Development and Disease Study Section[SBDD]


NIH_SPENDING_CATS: Aging;Biotechnology;Cancer;Cancer Genomics;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Prevention;Prostate Cancer;Racial and Ethnic Minority Health Research;Social Determinants of Health;Urologic Diseases

ORG_CITY: SYDNEY

ORG_COUNTRY: AUSTRALIA

ORG_FIPS: AS

ORG_NAME: UNIVERSITY OF SYDNEY

PHR: Genomic bases for African geo-ethnic prostate cancer health disparity PROJECT NARRATIVE Having an African ancestry is a significant risk factor for lethal prostate cancer (PCa). Here we will use the power of genomics and a unique global resource spanning the United Sates, South America and Africa, to determine the contribution of genetic and non-genetic factors, with the aim to close the gap in PCa health disparities.

PI_NAMEs: HAYES, VANESSA MARIE (contact)

PROGRAM_OFFICER_NAME: FINGERMAN, IAN M

PROJECT_TERMS: Address;Admixture;Africa;Africa South of the Sahara;African;African American;African ancestry;Age;Agreement;base;Biological;Black race;Blood;Brazil;cancer genome;cancer health disparity;carcinogenicity;Carcinogens;Chicago;Chronic;clinically relevant;Collaborations;Complex;Data;Death Rate;Diagnosis;Disease;disorder risk;Disparity;diversity and inclusion;dysbiosis;Early Diagnosis;Environment;Environmental Carcinogens;ethnic disparity;ethnic health disparity;Ethnic Origin;Etiology;European;European ancestry;Exclusion;Future;Generations;Genetic;Genetic Predisposition to Disease;genetic testing;Genetic Variation;Genome;genome sequencing;genomic data;Genomic medicine;genomic profiling;Genomics;Geography;Germ Lines;Germ-Line Mutation;Health;high risk;Infectious Agent;Inflammation;Inherited;insight;Knowledge;Leadership;Link;Malignant neoplasm of prostate;Malignant Neoplasms;men;microbiota;Minority;modifiable risk;Molecular;mortality;Mutation;National Comprehensive Cancer Network;Nature;neoplasm resource;non-genetic;novel;Oncogenic;Outcome;pathogen;pathogenic microbe;Pathogenicity;Patients;Pattern;Pattern Recognition;Population;precision medicine;Prevention;Prostate;Prostatic Neoplasms;Publishing;Recommendation;Recording of previous events;Reporting;Resources;Risk;Risk Factors;Role;Shotguns;skills;socioeconomics;Somatic Mutation;South Africa;South African;South America;Southern Africa;Specificity;Structure of base of prostate;Taxonomy;Testing;Tissues;tumor;United States;Variant;Virus;Whole Blood;whole genome;Work

STUDY_SECTION: BMCD

STUDY_SECTION_NAME: Basic Mechanisms of Cancer Health Disparities Study Section[BMCD]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Aging;Cardiovascular;Estrogen;Hypertension;Kidney Disease;Women's Health Research

PHR: High blood pressure is the leading cause of cardiovascular disease and death world-wide. Young women are protected against high blood pressure, but this protection is lost after menopause, indicating a crucial role for estrogen. This study is designed to investigate the role of a new estrogen receptor and previous pregnancy on blood pressure later in life in women, with the intension of understanding the potential of targeting estrogen signaling in elder women suffering from high blood pressure.

PI_NAMEs: GOHAR, EMAN  (contact)

PROGRAM_OFFICER_NAME: VARAGIC, JASMINA

PROJECT_TERMS: Academic Medical Centers;Adrenal Glands;age related;aged;aging population;aging process;Aldosterone;American;Anabolism;Animal Experimentation;Animals;Anti-Hypertensive Agents;biobank;Blood Pressure;blood pressure reduction;blood pressure regulation;Cardiovascular Diseases;Cardiovascular system;Caring;Cells;Cessation of life;Data;Death Rate;design;Development;DNA;DNA Repository;Duct (organ) structure;Ductal Epithelium;Elderly woman;Electrophysiology (science);Endothelin-1;epithelial Na+ channel;ESR1 gene;Estradiol;Estrogen Receptor 2;Estrogen Receptors;Estrogens;Excretory function;experimental study;Female;genetic variant;Genotype;GPER gene;Health;Human;Hypertension;Impairment;improved;Kidney;Knock-out;Knockout Mice;Knowledge;Life;life span;Long-Term Effects;Longitudinal Studies;Mediating;Menopause;Meta-Analysis;Molecular;Mus;Natriuresis;normal aging;Nulliparity;Ovarian;Ovarian aging;parity;parous;patch clamp;personalized medicine;pharmacologic;Plasma;Polycystic Ovary Syndrome;Population;Postmenopause;Pregnancy;preservation;Prevalence;Production;prospective;Rattus;Regulation;Reporting;Reproductive History;Risk;Risk Factors;Role;Scheme;sex as a biological variable;Signal Transduction;Testing;therapeutic target;timeline;Tubular formation;urinary;Woman;Women's study;young woman

PROJECT_TITLE: Unraveling the Impact of Estrogen Signaling on Postmenopausal Hypertension

STUDY_SECTION: IVPP

STUDY_SECTION_NAME: Integrative Vascular Physiology and Pathology Study Section[IVPP]


ORG_CITY: BOSTON

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: PROJECT NARRATIVE This project focuses on studying a new mechanism leading to salt-sensitive hypertension, which contributes to substantial morbidity, mortality, and healthcare costs. The proposed research will study a novel role of a cytoskeletal protein—previously known to be linked to glomerular disease— in sodium homeostasis and blood pressure regulation. Defining the role of this protein in salt-sensitivity will provide critical insights into salt- sensitive hypertension, laying the foundation for future targets for anti-hypertensive therapy.

PI_NAMEs: FENG, DI  (contact)

PROJECT_TERMS: absorption;Actinin;Acute;Adult;Animal Model;Animals;Anti-Hypertensive Agents;Apical;apical membrane;Blood Pressure;blood pressure reduction;blood pressure regulation;Cell surface;Cells;Chronic;Crosslinker;Cytoskeletal Proteins;Cytoskeleton;Data;Disease;Endocytosis;Exocytosis;experience;F-Actin;Foundations;Functional disorder;Furosemide;Future;Goals;Health Care Costs;Homeostasis;Human;Hypertension;Image;Impairment;in vivo;innovation;insight;Kidney;Kidney Diseases;kidney medulla;Limb structure;Link;Measures;Mediating;Modeling;Morbidity - disease rate;mortality;mutant;Mutate;Natriuresis;new therapeutic target;novel;organ on a chip;Physiological;Play;podocyte;pressure;Proteins;Rattus;Regulation;Renal glomerular disease;Research;response;Role;salt sensitive hypertension;shear stress;Sodium;Sodium Chloride;Stress;Stretching;Surface;symporter;targeted treatment;Technology;Thick;Time;trafficking;uptake;Work

PROJECT_TITLE: Novel Role Of ACTN4 in Sodium Reabsorption and Salt-Sensitive Hypertension


NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Cardiovascular;Clinical Research;Heart Disease;Lung

ORG_DEPT: SURGERY

PHR: Project Narrative While mechanically assisted circulation (MAC), such as mechanical circulatory support (MCS) with ventricular assist devices (VADs), extracorporeal membrane oxygenation (ECMO) and cardiopulmonary bypass (CPB), is routinely implemented to treat patients with advanced heart failure and respiratory failure, infections are a common postoperative complication in patients with MAC. Infections can develop into life-threatening events. Current MAC devices are based almost exclusively on rotary blood pump technology, in which an impeller rotating at high-speed pumps the blood, inevitably resulting in high mechanical shear stress (HMSS) that can damage blood components, including leukocytes. The goal of this project is to gain a better understanding of HMSS-induced neutrophil dysfunction associated with MAC through quantifiable measurements with well- controlled experiments. This knowledge can be used by clinicians to better diagnose and treat patients, and by engineers to develop less traumatic, next-generation biocompatible devices for MAC therapies.

PI_NAMEs: WU, ZHONGJUN JON (contact)

PROGRAM_OFFICER_NAME: AGRAWAL, NITIN

PROJECT_TERMS: Activities of Daily Living;Acute;Adaptor Signaling Protein;adhesion receptor;Adhesions;Affect;American;Assisted Circulation;bactericide;Biological;Biological Markers;biomaterial compatibility;Biomedical Engineering;Blood;Blood Cells;blood damage;blood pump;Blood specimen;Cardiac Surgery procedures;Cardiopulmonary;Cardiopulmonary Bypass;Cells;Chemicals;Clinical;clinically relevant;Communicable Diseases;Cytoskeleton;Data;Device Designs;Devices;Diagnosis;Disease;Endothelium;Engineering;Environment;Event;Evolution;exhaust;experimental study;Exposure to;Extracorporeal Membrane Oxygenation;Functional disorder;Goals;healthy volunteer;Heart;Heart Diseases;Heart failure;Heart Transplantation;Hemorrhage;Immune;Immune system;implantation;improved;In Vitro;in vivo;Infection;infection risk;inhibitor;injured;Injury;Integrins;Knowledge;Length;Leukocytes;Life;Link;Lung;Lung Diseases;lung failure;Lung Transplantation;Measurement;Measures;mechanical circulatory support;mechanical device;Mechanics;Mediating;migration;Modeling;Morbidity - disease rate;mortality;neutrophil;Neutrophil Activation;next generation;novel;Organ;Oxidative Stress;Patient-Focused Outcomes;Patients;Phagocytosis;Phenotype;PI3K/AKT;Plasma;Postoperative Complications;Postoperative Period;Proteins;Proteolysis;Pump;Quality of life;receptor;Regression Analysis;Research;respiratory;Respiratory Disease;Respiratory Failure;risk mitigation;risk stratification;Rotation;Series;shear stress;Sheep;sheep model;Signal Pathway;Signal Transduction;Speed;Structure;Surface;Survival Rate;Syndrome;System;Technology;Time;Transplant Recipients;ventricular assist device

PROJECT_TITLE: High Mechanical Shear Stress-Induced Neutrophil Dysfunction in Mechanically Assisted Circulation

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Gene Therapy;Genetics;Heart Disease;Muscular Dystrophy;Rare Diseases

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: PROJECT NARRATIVE Heart failure and muscular dystrophy are devastating diseases that affect tens of millions of people worldwide, and while these disorders are highly complex in nature, a common feature they share is dysregulated calcium signaling. We recently discovered a small protein called DWORF that can rescue calcium defects in the heart when it is overexpressed and protects from disease. The studies proposed here will leverage a newly developed gene therapy strategy that is optimized for enhanced heart and skeletal muscle gene delivery to comprehensively test the therapeutic potential of DWORF as a novel gene therapy target for the treatment of heart failure and muscular dystrophy.

PI_NAMEs: MAKAREWICH, CATHERINE A (contact);MOLKENTIN, JEFFERY D

PROGRAM_OFFICER_NAME: SHI, YANG

PROJECT_TERMS: Address;Adult;Affect;Affinity;aged;Alleles;Amino Acids;Animal Model;Animals;Arginine;Arrhythmia;Attenuated;Binding;Blood Vessels;Calcium;Calcium Signaling;Capsid;Cardiac;Cardiac Myocytes;cardioprotection;Characteristics;Clinical;Clinical Trials;clinically relevant;Complex;Cytoplasm;Data;Defect;Dependovirus;Dilated Cardiomyopathy;Disease;Duchenne muscular dystrophy;dwarf open reading frame;Dystrophin;Echocardiography;Etiology;Excision;Exhibits;Failure;family genetics;Female;Functional disorder;Future;Gene Deletion;Gene Delivery;gene therapy;Gene therapy trial;gene-targeted therapy;Genes;Genetic;Genetic Diseases;Heart;Heart failure;heart function;Heterozygote;Homeostasis;Human;human disease;humanized mouse;Impairment;improved;in vivo;in vivo monitoring;Individual;Injections;Injury;Knock-in Mouse;Lead;Mediating;Membrane;membrane skeleton;Mitochondria;Modeling;Molecular;mouse model;Mus;Muscle;Muscle Cells;Muscle Contraction;Muscle Development;Muscle function;Muscular Dystrophies;Mutation;Myocardial Infarction;Myocardium;Myopathy;Nature;Necrosis;neonate;new therapeutic target;novel;overexpression;Pathogenesis;Pathogenicity;Patients;Penetration;Persons;Phenotype;phospholamban;Play;Positioning Attribute;postnatal;pressure;prevent;Property;Proteins;Relaxation;Research Personnel;reuptake;Role;Rupture;Sarcoplasmic Reticulum;sarcoplasmic reticulum calcium ATPase;Satellite Viruses;SERCA2a;Signal Transduction;Site;Skeletal Muscle;Striated Muscles;symptom treatment;System;Technology;Testing;Therapeutic;therapeutic evaluation;therapeutic gene;therapeutic target;Time;tool;Transgenes;translational study;uptake;Utrophin;vector;Ventricular Arrhythmia;Virus;Visit

PROJECT_TITLE: Developing DWORF gene therapy to treat heart failure and muscular dystrophy

STUDY_SECTION: TAG

STUDY_SECTION_NAME: Therapeutic Approaches to Genetic Diseases Study Section[TAG]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Health Services;Hematology;Pediatric;Pediatric Cancer;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Narrative Hematopoietic stem cell transplantation is used to treat life-threatening blood disorders and often requires a healthy living donor. Recent medical advances have allowed parents to donate to their children and vice versa, but little is known about how these parent/child donors experience the donation process – particularly if the recipient has complications or dies. With this project, we hope to better understand donor experiences and quality-of-life and how transplant physicians make decisions about when to use a parent or child donor.

PI_NAMEs: PULSIPHER, MICHAEL A;SWITZER, GALEN E. (contact)

PROGRAM_OFFICER_NAME: HAILU, BENYAM

PROJECT_TERMS: Adolescent;Adult;Age;aged;Allogenic;Caring;Cells;Characteristics;Chemotherapy and/or radiation;Child;Clinical;clinical application;comparison group;Consensus;Decision Making;Development;Disease;Donor Selection;Dose;ethnic minority;Ethnic Origin;experience;Family;Focus Groups;Foundations;Frequencies;Geography;Goals;graft vs host disease;Guidelines;Health;health related quality of life;Health Status;Hematological Disease;Hematopoietic Neoplasms;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;Immune system;improved;Infusion procedures;innovation;Interview;Investigation;Life;Living Donors;Matched Group;Medical;Methods;Nature;novel;Online Systems;Outcome;Parents;Patients;Pattern;Physician's Practice Patterns;Physicians;Practice Management;Prevention;Probability;Process;psychosocial;Quality of life;Race;Recommendation;Research;Retrospective cohort;Sampling;Scientific Advances and Accomplishments;Series;Siblings;Source;Structure;Surveys;Telephone Interviews;transplant centers;Transplantation;Variant

PROJECT_TITLE: Donor health-related quality-of-life and physician decision-making in the context of haploidentical hematopoietic stem cell transplantation (HaploQOL)

STUDY_SECTION: HSQE

STUDY_SECTION_NAME: Health Services: Quality and Effectiveness Study Section[HSQE]


NIH_SPENDING_CATS: Biomedical Imaging;Brain Disorders;Clinical Research;Epilepsy;Neurodegenerative;Neurosciences

PHR: PROJECT NARRATIVE Epilepsy surgery can result in seizure freedom in patients with drug-resistant epilepsy. Current clinical tools that guide surgical decisions are limited, in part due to an incomplete understanding of brain connectivity patterns in focal epilepsy. Using magnetic resonance imaging and intracranial recordings, we will develop new network- based tools that can be applied broadly at epilepsy centers to improve patient selection, outcome prediction, and localization of surgical targets in epilepsy surgery.

PI_NAMEs: ENGLOT, DARIO J (contact)

PROGRAM_OFFICER_NAME: WHITTEMORE, VICKY R

PROJECT_TERMS: Ablation;Automobile Driving;Bilateral;Brain;Brain Diseases;brain magnetic resonance imaging;Brain region;Clinical;connectome;Development;Diffusion Magnetic Resonance Imaging;Disabling;Disease;Drug resistance;Electric Stimulation;Electrodes;Electroencephalography;Electrophysiology (science);Ensure;Epilepsy;Evaluation;Evoked Potentials;Excision;feature extraction;Fingerprint;Freedom;Functional disorder;Functional Magnetic Resonance Imaging;Generations;Goals;improved;Individual;innovation;Intractable Epilepsy;Left;Magnetic Resonance Imaging;Measurement;Measures;medial temporal lobe;Modality;Modeling;Monitor;multimodality;Nature;neocortical;Network-based;neuroimaging;Neurologic;novel;Operative Surgical Procedures;Outcome;outcome prediction;Partial Epilepsies;Pathway Analysis;Patient Care;Patient Selection;patient stratification;Patients;Pattern;Pharmaceutical Preparations;Quality of life;research clinical testing;Resistance;response;Rest;Scalp structure;segregation;Seizures;structural imaging;Subgroup;supervised learning;surgery outcome;Techniques;Technology;Temporal Lobe Epilepsy;temporal measurement;Testing;tool;white matter;Work

PROJECT_TITLE: Development of multimodal network analyses to improve epilepsy surgery outcomes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 EITN-L (90)]


NIH_SPENDING_CATS: Biotechnology;Diabetes;Kidney Disease;Orphan Drug;Rare Diseases

ORG_CITY: CHICAGO

ORG_NAME: RUSH UNIVERSITY MEDICAL CENTER

ORG_STATE: IL

PHR: Project narrative Recombinant mutated human Angiopoietin-like 4 protein will be investigated for its potential role in reducing or eliminating the progression of chronic kidney disease in rat and minpig models. Anti-apoptosis mechanisms that maintain interstitial capillary endothelium integrity and keep repair vessels open to reduce interstitial fibrosis will be investigated in endothelial Integrin knockout mouse models.

PI_NAMEs: CHUGH, SUMANT SINGH (contact);CLEMENT, LIONEL CLAUDIUS

PROGRAM_OFFICER_NAME: CHAN, KEVIN E

PROJECT_TERMS: Adipose tissue;Adverse effects;Angiotensin II Receptor;Angiotensin-Converting Enzyme Inhibitors;ANGPTL4 gene;Animal Model;Animals;Apoptosis;Autologous;Binding;Biological;Biological Assay;Biological Process;Blood capillaries;Blood Pressure;Chronic Kidney Failure;comparative efficacy;Creatinine;Data;Development;diabetes risk;Diabetic Nephropathy;diabetic rat;Disease Progression;drug candidate;Drug usage;efficacy evaluation;efficacy study;End stage renal failure;Endothelium;Enzyme-Linked Immunosorbent Assay;experimental study;Fibrosis;Focal and Segmental Glomerulosclerosis;glomerular endothelium;Glomerular Filtration Rate;Glomerulonephritis;glycemic control;Half-Life;Heart;Human;human model;Hypertriglyceridemia;Immune response;improved;In Situ Nick-End Labeling;inhibitor;inhibitor therapy;Integrin alpha3beta1;Integrins;interstitial;Intravenous;intravenous injection;Inulin;Kidney;Kidney Diseases;Knockout Mice;Laboratories;lipoprotein lipase;Lisinopril;Losartan;LoxP-flanked allele;Mass Spectrum Analysis;Mediating;Miniature Swine;Minor;Modeling;Molecular;Monitor;mouse model;Mus;Mutate;Mutation;Nephritis;Nephrotic Syndrome;nephrotoxicity;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutics;Organ;Pathogenesis;Pathway interactions;Patients;Peptides;Phase;Plasma;podocyte;preservation;prevent;Proteins;Proteinuria;Publishing;Rattus;Recombinants;Recommendation;Renin-Angiotensin System;repaired;Rodent;Role;Serum;sialylation;Site;Skeletal Muscle;Stains;subcutaneous;Subcutaneous Injections;systemic toxicity;Telemetry;Therapeutic;Therapeutic Effect;Therapeutic Studies;Toxic effect;transgene expression;Transgenes;Transgenic Organisms;United States Food and Drug Administration;Variant

PROJECT_TITLE: Recombinant hANGPTL4 and CKD

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


ADMINISTERING_IC: AR

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Neurosciences;Physical Injury - Accidents and Adverse Effects;Physical Rehabilitation;Rehabilitation

ORG_CITY: LEXINGTON

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: Project Narrative Anterior cruciate ligament tears are a common injury, and in spite of surgical reconstruction and rehabilitation there remain significant impairments in the quadriceps muscle, which contribute to poor long term outcomes. This project has identified a molecular signature of quadriceps neuromuscular dysfunction that contributes to the initial loss of quadriceps muscle strength. An innovative combination of pre-clinical studies and a mechanistic clinical trial will determine the ability of neuromuscular electrical stimulation to mitigate this early molecular signature and restore quadriceps strength.

PI_NAMEs: FRY, CHRISTOPHER  (contact);NOEHREN, BRIAN

PROGRAM_OFFICER_NAME: WASHABAUGH, CHARLES H

PROJECT_TERMS: Address;anterior cruciate ligament injury;anterior cruciate ligament reconstruction;anterior cruciate ligament rupture;Atlases;Atrophic;Biological;Biopsy;Caring;Cell Nucleus;ChIP-seq;chromatin immunoprecipitation;Clinical Practice Guideline;Clinical Trials;Data;Deacetylase;defined contribution;Denervation;Development;Etiology;Event;evidence based guidelines;experimental study;Fiber;Functional disorder;gain of function;gene induction;gene induction/repression;Genetic;HDAC4 gene;Histone Deacetylase Inhibitor;human data;Impairment;improved outcome;Individual;Injury;innovation;insight;Knockout Mice;Knowledge;Link;loss of function;Measures;Modeling;Molecular;Molecular and Cellular Biology;Molecular Profiling;molecular targeted therapies;Morphology;multidisciplinary;Mus;Muscle;Muscle function;muscle strength;Muscle Weakness;Muscular Atrophy;neural;neuromuscular;Neuromuscular Junction;neuromuscular stimulation;novel;Nuclear;Nuclear RNA;Operative Surgical Procedures;Orthopedic Surgery;Outcome;Participant;Pathway interactions;Peripheral;pharmacologic;Phenotype;Physical therapy;Positioning Attribute;Postoperative Period;pre-clinical;preclinical study;Protocols documentation;quadriceps muscle;Randomized;reconstruction;Reconstructive Surgical Procedures;Recovery;Recovery of Function;regenerative rehabilitation;Rehabilitation therapy;Resolution;response;Role;Signal Transduction;single nucleus RNA-sequencing;Skeletal Muscle;statistics;Testing;Therapeutic;Time;Torque;transcriptional reprogramming;transcriptome;transcriptome sequencing;Translations;Work

PROJECT_TITLE: Mechanistic Assessment of NMES to Rescue Localized Neuromuscular Disruption after ACL Injury

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 SMEP-C (05)]