NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Congenital Structural Anomalies;Data Science;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pediatric

PI_NAMEs: MAGA, ALI MURAT (contact)

PROJECT_TERMS: 3-Dimensional;Anatomy;Atlases;automated segmentation;Biological Assay;Communities;computational anatomy;Computer Vision Systems;Consumption;contrast enhanced;Data;Data Analyses;Data Set;deep learning;deep learning model;Detection;Development;Dimensions;Etiology;fetal;Fetal Development;Fetus;Genomics;Genotype;Goals;Harvest;Human;Image;imaging Segmentation;insight;interest;Iodine;Machine Learning;machine learning model;microCT;Modeling;molecular phenotype;Morphology;mouse development;mouse model;Mus;mutant;Mutant Strains Mice;Mutation;next generation;open source;organ growth;Organogenesis;phenomics;Phenotype;Population;Protocols documentation;Publishing;Random Allocation;Reproducibility;Resolution;Sampling;Scanning;Shapes;soft tissue;statistics;Structural Congenital Anomalies;Structural defect;Structure;Technology;Three-Dimensional Image;Three-Dimensional Imaging;Tissues;tool;Training;transcriptome sequencing;user-friendly;Variant;X-Ray Computed Tomography

PROJECT_TITLE: Project II - 3D Quantitative Analysis of Mouse Models of Structural Birth Defects Through Computational Anatomy


ADMINISTERING_IC: DK

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Digestive Diseases;Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: SAINT LOUIS

ORG_COUNTRY: UNITED STATES

ORG_DEPT: OTHER BASIC SCIENCES

ORG_FIPS: US

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE  This research project and training plan will provide advanced training in bioinformatics/biostatistics (for scRNA-seq, RNA-seq, and ChIP-seq), organoid culture, Helicobacter pylori infection, and High-content imaging to explore the regulation of cell identity and growth in differentiated cells of the gastric epithelium. The studies proposed in this application will provide key insights into how gastric cell identity is maintained, controlled, and perturbed in disease states.

PI_NAMEs: WILLET, SPENCER GAFFNEY (contact)

PROGRAM_OFFICER_NAME: SASLOWSKY, DAVID E

PROJECT_TERMS: Acute;Address;Advisory Committees;Atrophic Gastritis;Bioethics;Bioinformatics;Biology;Biometry;career development;cell dedifferentiation;Cell Differentiation process;cell growth;Cell Line;Cell Proliferation;Cell Shape;Cells;cellular transduction;Chief Cell;ChIP-seq;Chronic;Data;Data Set;Development;Disease;Disease Progression;Educational workshop;Epithelial Cells;Epithelium;experience;experimental study;follow-up;Frequencies;Future;Gastric Adenocarcinoma;Gastric Metaplasia;gastric organoids;Gene Expression;Generations;Genes;Grant;Growth;Helicobacter Infections;Homeostasis;Human;Image;In Vitro;in vitro Model;in vivo;Injury;insight;interest;Internal Ribosome Entry Site;International;Journals;Laboratories;LoxP-flanked allele;Manuscripts;meetings;Mentorship;Metaplasia;Metaplastic Cell;Modeling;Molecular;Molecular Target;mouse genetics;mouse model;Mutation;Neurofibromin 2;novel;Nuclear;Organ;Organoids;Pathway interactions;pathway tools;patient population;Patients;Phase;Phenotype;Population;Preparation;prevent;Principal Investigator;Regulation;Research;Research Project Grants;Research Training;response;response to injury;Risk;Role;Sampling;Scaffolding Protein;Science;Series;Signal Pathway;Signal Transduction;single-cell RNA sequencing;skill acquisition;skills;Smooth Pursuit;spasmolytic polypeptide;stem-like cell;stemness;Stomach;Stomach Diseases;symposium;targeted treatment;Techniques;Testing;Time;tool;Training;transcriptome sequencing;United States National Institutes of Health;Visit

PROJECT_TITLE: The role of the Hippo Pathway in gastric homeostasis and metaplasia

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


ADMINISTERING_IC: HG

ED_INST_TYPE: GRADUATE SCHOOLS

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

ORG_CITY: MADISON

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Narrative A human genome has 46 DNA molecules, some many inches in length, and when laid end-to- end they span almost 6 feet in length. Consequently, it is now impossible to make human genomes in the laboratory. This challenge will be met by greatly simplifying genome manufacturing through new large-scale chromosome construction technologies that assemble large “chunks” of DNA into chromosome-sized molecules by directly harnessing the very intrinsic physical properties that make them “difficult” objects to deal with.

PI_NAMEs: SCHWARTZ, DAVID C. (contact)

PROGRAM_OFFICER_NAME: NOVA, IAN CURTIS

PROJECT_TERMS: Adsorption;Attenuated;Bacterial Artificial Chromosomes;Binding;Biological Assay;Buffers;Cells;Charge;Chemicals;Chromosomes;Complement;Computer Models;Computer Simulation;copolymer;Coupling;Derivation procedure;design;Device Designs;Dimensions;DNA;DNA Binding;DNA biosynthesis;DNA Ligation;electric field;Engineering;fabrication;Fluorescence;foot;Genome;Genomic DNA;Genomics;Glass;Grain;Health;Human;Human Genome;Image;Image Analysis;In Vitro;Ionic Strengths;Laboratories;Length;Ligation;manufacture;Maps;Measurement;Mediating;Methods;microscopic imaging;Microscopy;Modality;Modeling;Modification;Molecular;Molecular Conformation;molecular modeling;monomer;Names;novel;Nucleic Acids;Oligonucleotides;operation;Optics;Pathway interactions;Peptides;Performance;Periodicity;Phase;Physical condensation;physical property;polyacrylamide;polyacrylamide hydrogels;Polyamines;Process;Reagent;Reproducibility;Research;research and development;response;Scheme;single molecule;Solid;Stretching;Surface;synergism;synthetic construct;synthetic nucleic acid;System;Techniques;Technology;technology development;Validation

PROJECT_TITLE: GenSyn: A Cycle for Serial Assembly of Very Large DNA Molecules


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Clinical Research;HIV/AIDS;Infectious Diseases;Microbiome;Prevention;Sexually Transmitted Infections;Women's Health Research

ORG_CITY: WASHINGTON

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: GEORGE WASHINGTON UNIVERSITY

ORG_STATE: DC

PHR: PROJECT NARRATIVE The proposed research is relevant to public health, because little is known regarding how individuals acquire the genital bacteria species that increase HIV risk and how to remove them. By studying the impact of sex and antimicrobials on the penile microbiome and what can predict the outcomes, this project will build new knowledge regarding how to design new strategies to prevent and reduce carriage of genital bacteria that are associated with HIV risk and other poor health outcomes. Therefore, the proposed research is relevant to the NIH mission to better understand and prevent infectious diseases, including HIV.

PI_NAMEs: LIU, CINDY  (contact)

PROGRAM_OFFICER_NAME: KIRKALI, ZIYA

PROJECT_TERMS: Adjuvant;Affect;Aftercare;Anaerobic Bacteria;antimicrobial;arm;Automobile Driving;Bacteria;Biological;Cells;Clindamycin;Coculture Techniques;Coitus;Communicable Diseases;Couples;density;design;Development;dysbiosis;Epidemiology;fighting;genital microbiome;Genitalia;Goals;Heterosexuals;HIV;HIV risk;Hour;Hydrogen Peroxide;Immune;Immune response;Immunoglobulin A;in vitro Model;Individual;innovation;Intervention Studies;Knowledge;Link;Male Adolescents;Male Circumcision;men;Metagenomics;Metronidazole;microbiome;microbiome composition;Mission;Modeling;Mucosal Immune Responses;Mucous Membrane;novel;Observational Study;Oral;Outcome;outcome prediction;Oxygen;pandemic disease;penile microbiome;penis;penis foreskin;poor health outcome;Predisposition;prevent;Prevention strategy;Public Health;recruit;Reproducibility;Research;Research Design;response;Risk Factors;sex;sexual debut;Sexual Transmission;Sexually Transmitted Diseases;Shapes;Testing;Tinidazole;topical anti-microbial;Topical application;transmission process;treatment arm;Treatment outcome;United States National Institutes of Health;Vagina;vaginal microbiome;Viral;Woman;Work

PROJECT_TITLE: How sex, host microenvironment, and immune responses shape acquisition of genital bacteria that increase HIV risk

STUDY_SECTION: HIVD

STUDY_SECTION_NAME: HIV Immunopathogenesis and Vaccine Development Study Section[HIVD]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Aging;Biomedical Imaging;Cancer;Clinical Research;Prevention;Prostate Cancer;Urologic Diseases

ORG_DEPT: SURGERY

PHR: PROJECT NARRATIVE Many of the invasive transrectal prostate biopsies performed for PSA screening are unnecessary—50% of the men undergoing a biopsy do not have prostate cancer. Although biomarkers and magnetic resonance imaging (MRI) has been used more often to help better select men for biopsy, these tools are not accurate enough to replace biopsy. We have developed a new way of analyzing the MRI images called diffusion histology imaging (DHI) that can accurately and non-invasively diagnose prostate cancer, which has the potential to reduce—if not eliminate—unnecessary prostate biopsies.

PI_NAMEs: IPPOLITO, JOSEPH EDWARD (contact);JOHNSON, MICHAEL HIROSHI;KIM, ERIC H

PROGRAM_OFFICER_NAME: AVULA, LEELA RANI

PROJECT_TERMS: accurate diagnosis;Address;artificial intelligence algorithm;Benign;Benign Prostatic Hypertrophy;Biological Markers;Biopsy;Blood;Blood Tests;cancer diagnosis;Cancer Patient;Classification;Clinical;clinical care;clinical imaging;clinical risk;clinical translation;clinically significant;cohort;Data;Diagnosis;Diagnostic;Diffusion;Disease Progression;disorder risk;Extraprostatic;General Population;Gleason Grade for Prostate Cancer;Goals;high risk;Histology;Hospitalization;Image;improved;Indolent;Interdisciplinary Study;Invaded;Liquid substance;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Malignant neoplasm of prostate;Malignant Neoplasms;men;Methods;Modeling;Monitor;Nomograms;Non-Invasive Detection;non-invasive monitor;noninvasive diagnosis;novel;Operative Surgical Procedures;overtreatment;Pathologic;Pathology;patient screening;Patient Selection;patient subsets;Patients;performance tests;Periodicals;Procedures;prospective;Prostate;prostate biopsy;prostate cancer risk;Prostate-Specific Antigen;Prostatectomy;Prostatic Diseases;prostatitis;Protocols documentation;PSA screening;Radiation;Radical Prostatectomy;recruit;Rectum;Reference Standards;research clinical testing;Risk;risk prediction;risk stratification;screening;Seminal Vesicles;Sensitivity and Specificity;Sepsis;spectrograph;standard of care;Testing;Tissues;tool;training data;tumor;United States;Update;Urine;Visualization

PROJECT_TITLE: Diffusion Histology Imaging: A Clinical Tool to Non-Invasively Diagnose and Manage Prostate Cancer

STUDY_SECTION: CBSS

STUDY_SECTION_NAME: Cancer Biomarkers Study Section[CBSS]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Biotechnology;Congenital Structural Anomalies;Genetics;Human Genome;Pediatric

ORG_CITY: SEATTLE

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

ORG_STATE: WA

PI_NAMEs: DIPPLE, KATRINA M (contact)

PROJECT_TERMS: Adoption;Affect;Area;base;Base Pairing;Biopsy;Blood;Body System;candidate validation;causal variant;Cells;Child;Clinical;clinical diagnostics;clinical phenotype;clinically relevant;Code;collaborative environment;Congenital Abnormality;Copy Number Polymorphism;cost;Data;deep sequencing;Diagnosis;Diagnostic;DNA;DNA Methylation;DNA Modification Process;DNA Sequence Alteration;DNA sequencing;Environmental Risk Factor;Epigenetic Process;Etiology;Evaluation;exome;exome sequencing;Gene Abnormality;Gene Expression;Genetic;genetic architecture;genetic disorder diagnosis;genetic testing;genetic variant;Genetic Variation;Genome;genome sequencing;genome wide association study;Genomics;Goals;Human;Human Development;improved;Individual;Infant;infant morbidity;infant morbidity/mortality;Introns;Laboratory Scientists;Live Birth;Methods;Methylation;Modification;Molecular;Morbidity - disease rate;mortality;mosaic;mosaic variant;Mosaicism;Mutation;nanopore;National Institute of Child Health and Human Development;new technology;next generation;Patient Selection;Patients;perinatal period;Phenotype;Prevention;Prospective cohort;Protein Isoforms;Repetitive Sequence;RNA Splicing;Source;Structural Congenital Anomalies;Surgeon;Technology;Tissues;transcriptome sequencing;Transformed Cell Line;Untranslated RNA;Variant;whole genome;Work

PROJECT_TITLE: Project III - Comprehensive Genomic Evaluation of Structural Birth Defects


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: PHILADELPHIA

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE The stability, expression, and inheritance of genetic information depends on the packaging of our genome by specialized proteins. The disruption of this protein-DNA complex, called chromatin, results in the genome instability observed in virtually all types of cancer and in chromosomal birth defects like trisomy. My research combines evolutionary predictions with basic chromatin biology to generate unique insights into these disease and infertility states.

PI_NAMEs: LEVINE, MIA TAUNA (contact)

PROGRAM_OFFICER_NAME: ADKINS, RONALD

PROJECT_TERMS: Aging;Biochemistry;Biological;Biology;cancer type;Cell Physiology;Cellular biology;Chromatin;chromatin protein;Chromosome Segregation;Complex;Congenital Abnormality;Data;Disease;DNA;DNA Packaging;Drosophila melanogaster;Evolution;Funding;Genes;Genetic;genetic information;Genome;Genome Components;genome integrity;Genomic Instability;Genomic Segment;hazard;Infertility;innovation;insight;Investigation;Malignant Neoplasms;Mediating;Modeling;Molecular;Pathway interactions;preservation;protein protein interaction;Proteins;Publishing;Recurrence;Regulation;Research;Resolution;Satellite DNA;Shapes;System;telomere;Trisomy;virtual

PROJECT_TITLE: Causes and functional consequences of chromatin evolution

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: NEW YORK

ORG_DEPT: NEUROSCIENCES

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: Project Narrative Temporal lobe epilepsy (TLE) is a debilitating disorder that includes severe cognitive deficits that greatly impair quality of life. There is substantial evidence that hippocampal circuits are disrupted in epilepsy but it remains unclear whether these deficits are caused by local processing changes or altered inputs coming into hippocampus. This proposal examines how medial entorhinal cortex projections to the hippocampus are altered in epileptic mice and tests the causal role of this circuit in hippocampal synchronization.

PI_NAMEs: SHUMAN, TRISTAN  (contact)

PROGRAM_OFFICER_NAME: LEENDERS, MIRIAM

PROJECT_TERMS: active control;Automobile Driving;Calcium;cell type;Cells;Chronic;Code;Cognitive deficits;Data;dentate gyrus;designer receptors exclusively activated by designer drugs;Disease;entorhinal cortex;Epilepsy;Fire - disasters;Functional disorder;Head;Hippocampus;Image;Impairment;In Vitro;insight;Interneurons;Intervention;Learning;Lesion;Medial;Mediating;Memory;Memory impairment;Microscope;morris water maze;Mus;Neurons;Pathway interactions;Patients;Pattern;Phase;Quality of life;Rodent Model;Role;Running;Silicon;Site;Source;spatial memory;Speed;stellate cell;Techniques;Temporal Lobe Epilepsy;Testing;virtual;virtual reality;Virus

PROJECT_TITLE: Circuits Driving Spatial Coding Deficits in Epilepsy

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Dental, Oral, and Craniofacial Disease;Genetics;Hematology;Human Genome;Infectious Diseases;Lymphatic Research;Lymphoma;Rare Diseases

ORG_NAME: WISTAR INSTITUTE

PHR: Epstein-Barr Virus (EBV) is an orally transmitted human gamma herpesvirus and the causative agent of several lymphoid and epithelial cell malignancies that occur with high rates in HIV-AIDS patients. EBV-associated cancers are subject to variable expression of viral oncogenes that is controlled by epigenetic mechanisms. Elucidating the epigenetic mechanisms controlling EBV oncogene expression in different cell and tumor types will provide information necessary for the development of new therapies to prevent latent infection and EBV- associated pathogenesis.

PI_NAMEs: LIEBERMAN, PAUL M. (contact)

PROGRAM_OFFICER_NAME: MCNEALY, TAMARA L

PROJECT_TERMS: Architecture;ATP phosphohydrolase;ATRX gene;Autoimmunity;B lymphocyte immortalization;Binding;Binding Sites;Biological Assay;carcinogenesis;Cell Physiology;cell type;Cells;Chromatin;Chromatin Modeling;Chromosomes;cohesin;Complex;Cytosine;DAXX gene;demethylation;Development;DNA;DNA Methylation;EBV-associated disease;Environment;Epigenetic Process;epigenetic regulation;epigenome;Episome;Epithelial Cells;Epithelium;Epstein Barr virus associated oncogenesis;Epstein-Barr Virus Infections;Epstein-Barr Virus latency;Epstein-Barr Virus-Related Malignant Neoplasm;Event;Funding;gammaherpesvirus;Gene Expression;Gene Expression Profile;Gene Expression Regulation;Genetic Transcription;Genome;Goals;Histone H3.3;histone modification;Histones;HIV/AIDS;Human;Human Herpesvirus 4;Infection;latent infection;Latent virus infection phase;Lymphoid Cell;Malignant lymphoid neoplasm;Malignant Neoplasms;methylation pattern;MicroRNAs;Molecular Chaperones;Molecular Conformation;Mutation;Nature;novel therapeutics;Nucleosomes;Oncogenes;Oncogenic;Oral;Pathogenesis;Pathway interactions;Patients;PAX5 gene;Phase;Phenotype;Positioning Attribute;prevent;Process;programs;promoter;Proteins;Role;Testing;Therapeutic Intervention;tool;transcription factor;Transcriptional Regulation;transmission process;tumor;tumorigenesis;Viral;Viral Genes;Viral Genome;Viral Oncogene;Virus Latency

PROJECT_TITLE: Epigenetic Regulation of Epstein-Barr Virus

STUDY_SECTION: VIRA

STUDY_SECTION_NAME: Virology - A Study Section[VIRA]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Aging;Cardiovascular;Diabetes;Genetics;Heart Disease;Kidney Disease;Lung;Prevention;Rare Diseases

ORG_CITY: CHAPEL HILL

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Some individuals genetically make a little more than others a gene product that increases the severity of diabetic complications in heart and kidneys, because it leads to a production of excess production of oxygen radicals. Unbalanced oxygen radical production is known to underlie in aging-associated common diseases as well as in acute injuries, but whether and to what extent the variation in a diabetes-associated gene affects the severities of tissue damage in other diseases is not currently known. Identifying mechanisms by which variations of the genes that influence the severity of common disease conditions should help guide us to new means of treatments/preventions.

PI_NAMEs: MAEDA, NOBUYO  (contact)

PROGRAM_OFFICER_NAME: VARAGIC, JASMINA

PROJECT_TERMS: Actins;Acute;Acute Renal Failure with Renal Papillary Necrosis;Acute Respiratory Distress Syndrome;Affect;Age;age related;aging related;aging related disease;alveolar type II cell;Amino Acids;Angiotensin II;Animal Model;Antioxidants;Apoptosis;Apoptotic;Biological Models;Botulinum Toxins;Cardiac;Cardiac Myocytes;Cardiomyopathies;cardioprotection;cell growth;cell injury;cell motility;cell type;Cells;Cellular Stress;Cellular Structures;Cessation of life;Chronic Kidney Failure;cofactor;comorbidity;Complex;Complication;Complications of Diabetes Mellitus;COVID-19 pandemic;Cytokinesis;Data;Development;Diabetes Mellitus;diabetic;diabetic cardiomyopathy;Diabetic mouse;Diabetic Nephropathy;Disease;disease model;DNA Methylation;Docking;Dose;Elements;Environmental Risk Factor;Etiology;Evolution;gene product;Genes;Genetic;Genetic Recombination;genetic risk factor;Genetic study;Genetic Transcription;Genetic Variation;Glucose;Goals;Guanine Nucleotide Exchange Factors;Heart;heart disease prevention;Heart Diseases;Heart failure;heart function;Heart Hypertrophy;Human;human disease;Human Genetics;Hyperglycemia;Hyperlipidemia;Hypertension;in vivo;Individual;Infection;Inflammatory;Influenza A virus;Infusion procedures;Injury;Ischemia;Kidney;Kidney Diseases;Knowledge;Lipids;Liver;Long-Term Effects;Mediator;Methionine;Monitor;mouse model;Mus;Myocardial dysfunction;NADPH Oxidase;Nature;Neonatal;neonatal mice;non-diabetic;novel;novel therapeutic intervention;nuclear factor-erythroid 2;Nucleotides;older patient;Oral;Organelles;Oxidation-Reduction;Pathogenesis;Pathway interactions;Patients;Physiological;Population;Predisposition;prevent;Prevention;Process;Production;Progress Reports;Proteins;Reactive Oxygen Species;Renal function;renal ischemia;Reperfusion Injury;Reperfusion Therapy;Role;Severities;Severity of illness;Signal Transduction;Somatomedins;Superoxides;System;Testing;tissue injury;Tissues;treatment strategy;Tubular formation;Variant;Virus Diseases;Vitamin B 12;Work

PROJECT_TITLE: Animal Models for Studying the Genetics of Complex Diseases

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Aging;Assistive Technology;Bioengineering;Brain Disorders;Clinical Research;Neurodegenerative;Neurosciences;Parkinson's Disease;Rehabilitation

ORG_CITY: DURHAM

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: DUKE UNIVERSITY

PHR: Deep Brain Stimulation (DBS) lead placement is a challenging and time-intensive procedure often requiring patients to be awake to confirm motor symptom reduction and assess side effect profile intraoperatively. Evoked potentials (EPs) hold promise as biomarkers to guide appropriate placement of DBS leads more rapidly and accurately, possibly even in patients under anesthesia. In this way, the use of EPs as a biomarker may reduce surgical time, improve patient outcomes, and improve patient comfort.

PI_NAMEs: DALE, JAHRANE ANTONIO (contact)

PROGRAM_OFFICER_NAME: SIEBER, BETH-ANNE

PROJECT_TERMS: Acceleration;Affect;Anesthesia procedures;awake;Behavior;Behavioral;Biological Markers;Bradykinesia;career;Cell Nucleus;Cessation of life;Characteristics;Clinic;Clinical;cohort;Collaborations;Complex;Deep Brain Stimulation;deep field survey;Disease;Distant;doctoral student;dopaminergic neuron;Dorsal;Electrocorticogram;Electrodes;Environment;Equipment;Evoked Potentials;experience;experimental study;FDA approved;Feedback;follow-up;Frequencies;Future;Generations;Goals;Human;image guided;Implant;implantation;improved;Intervention;Knowledge;Lead;Link;Location;Medical;Mentors;Methods;Motor;Motor Cortex;motor symptom;Nervous System Disorder;neural;Neurodegenerative Disorders;Neurologist;Neurology;Neurons;Neurosurgeon;neurosurgery;novel;Operative Surgical Procedures;Outcome;Parkinson Disease;Pathology;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;Phenotype;Physicians;Postoperative Period;posture instability;Predictive Value;Preparation;Procedures;Process;radiological imaging;reduce symptoms;Refractory;Research;response;Scientist;Shuffling Gaits;side effect;skills;Stimulus;Structure of subthalamic nucleus;Surgeon;Surrogate Markers;symposium;symptom treatment;symptomatic improvement;Synapses;Techniques;Testing;Therapeutic;Time;Training;Tremor;Visit

PROJECT_TITLE: Characterizing Evoked Potentials of Deep Brain Stimulation for Parkinson's Disease


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Autism;Brain Disorders;Clinical Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Mental Illness;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Schizophrenia;Serious Mental Illness

ORG_NAME: NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC

PHR: This study has significant relevance for public health, as it is aimed at identifying prenatal risk factors, including markers of maternal oxidative stress, in schizophrenia and autism spectrum disorders in a large national birth cohort. These factors have never before been investigated in maternal sera in relation to these outcomes. The proposed research may offer the potential for prevention of these disorders by public health measures including reduction of exposure to factors that increase maternal oxidative stress, and could also result in an improved understanding of how prenatal insults alter brain development in these disorders.

PI_NAMEs: BROWN, ALAN STEWART (contact)

PROGRAM_OFFICER_NAME: LAWLER, CINDY P

PROJECT_TERMS: Address;Adverse effects;Antioxidants;Archives;Area;autism spectrum disorder;Behavioral;Biological Assay;Biological Markers;Birth;Brain;C-reactive protein;Clinical;cohort;Cohort Studies;Cotinine;Development;Diagnosis;Diagnostic;Dichlorodiphenyl Dichloroethylene;Disease;disorder prevention;DNA;early life exposure;Environmental Exposure;epidemiology study;Etiology;Event;Exposure to;fetal;Fetal Development;Finland;follow-up;Funding;Future;glutathione peroxidase;Health Policy;Hospitalization;improved;Inflammation;Investigation;Lipid Peroxidation;Lipids;maternal cigarette smoking;Maternal Exposure;maternal risk;maternal serum;Measures;Mediating;Mediator;Mental disorders;Neonatal;Nested Case-Control Study;neurodevelopment;Neurons;Neurosciences;neurotransmission;Nitrogen;novel;offspring;Outcome;oxidation;oxidative damage;Oxidative Stress;Oxygen;Pathogenicity;perinatal complications;Pesticides;Pregnancy;prenatal;prenatal exposure;prenatal risk factor;Prevention;Preventive;Process;Proliferating;Proteins;Public Health;public health relevance;Reactive Oxygen Species;Registries;Research;Resources;Risk;Risk Factors;Role;Sample Size;Sampling;Schizophrenia;Seroepidemiologic Studies;Serum;sex;Specimen;Superoxide Dismutase;System;Testing;therapeutic target;Thiobarbituric Acid Reactive Substances;translational study;Trichloroethanes;virtual;Work

PROJECT_TITLE: A national birth cohort study of prenatal factors and neurodevelopmental psychiatric disorders

STUDY_SECTION: BGES

STUDY_SECTION_NAME: Behavioral Genetics and Epidemiology Study Section[BGES]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Depression;Estrogen;Mental Health;Mental Illness;Neurosciences

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: Project Narrative This proposal addresses gaps in our knowledge on the neuromodulatory effects of circulating steroid hormones on reward and aversion behaviors, a function critical for survival. The proposed studies will examine the Lateral Habenula, integrating molecular to circuit-specific approaches, to better understand how reward and aversion- motivated behaviors are sculpted by sex hormones; thus providing a more comprehensive understanding of the dynamics between reward and aversion. Collectively, the findings from this research proposal have the potential to identify therapeutic targets for treating depression, anxiety, and addiction.

PI_NAMEs: BRIONES, BRANDY A. (contact)

PROGRAM_OFFICER_NAME: VAN'T VEER, ASHLEE VICTORIA

PROJECT_TERMS: addiction;Address;Androgens;Anhedonia;Anti-Anxiety Agents;Anxiety;Attenuated;Automobile Driving;Aversive Stimulus;Bar Codes;Behavior;Behavior Disorders;Behavioral;biological adaptation to stress;Brain;calcium indicator;Cell Nucleus;cell type;Clustered Regularly Interspaced Short Palindromic Repeats;Code;Cognition;Complex;Cues;Data;data resource;Data Set;Depressive disorder;depressive symptoms;Desire for food;dorsal raphe nucleus;Electric Stimulation;Electrophysiology (science);Elements;Estradiol;Estrogens;Etiology;experimental study;Exposure to;Female;Fiber;Fire - disasters;Fluorescent in Situ Hybridization;Functional disorder;Gene Expression;Genes;Gonadal Steroid Hormones;Habenula;hormonal signals;Hormone Receptor;hormone regulation;Hormones;insight;Knock-out;Knowledge;Lateral;Learning;Lesion;Machine Learning;male;Maps;Mental Depression;Mental disorders;mental set;Molecular;Monitor;mood regulation;motivated behavior;Motivation;Names;Negative Valence;neural;neural circuit;Neurons;neuropsychiatric disorder;neuropsychiatry;neuroregulation;neurotechnology;new therapeutic target;nonhuman primate;Nuclear Hormone Receptors;Output;Pattern;Population;Positive Valence;Progesterone;Punishment;Quinine;Research Proposals;response;reward circuitry;reward processing;Rewards;Rodent;Role;Sex Differences;Signal Transduction;Specificity;steroid hormone;steroid hormone receptor;Steroids;stress disorder;Sucrose;System;Taste Perception;Technology;Testing;Testosterone;therapeutic target;tool;Training;Uncertainty;Ventral Tegmental Area;Viral;Work

PROJECT_TITLE: Sex hormone regulation of Lateral Habenula circuitry for reward and aversion encoding


ORG_CITY: HADLEY

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF MASSACHUSETTS AMHERST

ORG_STATE: MA

PHR: PROJECT NARRATIVE Heparin and related glycosaminoglycans hold enormous promise in medicine, as their intimate involvement in processes ranging from cell proliferation and differentiation to immune regulation makes them a largely unexploited source of therapeutic agents that can address a variety of medically important conditions. However, heparin turns deadly in a subset of patients by triggering an immune disorder heparin-induced thrombocytopenia (HIT), which may be fatal if not immediately diagnosed and prompt actions taken. The proposed research will make a critical contribution towards understanding the molecular mechanism of interaction between heparin and platelet factor 4, two key players in the onset and progression of HIT, catalyzing development of reliable diagnostic/prognostic tools and potent therapeutic intervention strategies.

PI_NAMEs: KALTASHOV, IGOR A (contact)

PROGRAM_OFFICER_NAME: BARNES, CHARLES ASHLEY

PROJECT_TERMS: Address;Affect;Affinity;Allosteric Regulation;Alpha Granule;analytical tool;Antibodies;Anticoagulants;Architecture;Behavior;Binding;Binding Proteins;Biopolymers;Cell Differentiation process;Cell Proliferation;cohort;Collaborations;Complex;design;Development;Diagnosis;Diagnostic;diagnostic tool;Electrons;Environment;Etiology;Exhibits;Exopeptidase;Glycosaminoglycans;granule cell;Health;Hematology;Heparin;Heparin Binding;heparin-induced thrombocytopenia;Heterogeneity;Human body;Immune System Diseases;immunogenic;immunogenicity;immunoregulation;Intervention;Knowledge;macromolecule;Maps;Mass Spectrum Analysis;mast cell;Measures;Medical;Medicine;Molecular;molecular modeling;molecular targeted therapies;Pathogenicity;Pathology;patient subsets;Patients;PF4 Gene;Physiological Processes;Plasma;Play;Predisposition;prevent;Process;Prognosis;prognostic tool;Protein Isoforms;Proteins;Proteolytic Processing;Recombinant Antibody;Research;Resolution;Role;Site;small molecule;Source;stoichiometry;structural determinants;Structure;success;System;Techniques;Therapeutic;Therapeutic Agents;Therapeutic Intervention;therapeutic target;therapeutically effective;Thrombin;Thrombocytopenia;Thrombosis;tool;Universities;volunteer;Work

PROJECT_TITLE: An integrated mass spectrometry approach to study heparin structure-bioactivity

STUDY_SECTION: EBIT

STUDY_SECTION_NAME: Enabling Bioanalytical and Imaging Technologies Study Section[EBIT]


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Infectious Diseases;Lung;Orphan Drug;Rare Diseases

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: PROJECT NARRATIVE M. avium complex (MAC) lung disease is a growing clinical problem that surpasses that of TB, particularly in certain states including Virginia. We will utilize a state-wide clinical cohort of all MAC lung disease patients to understand what features of the organism (such as the species or subtype or drug resistance profile), the host (such as antibiotic drug absorption), and the environment (such as household exposure to MAC) are most important in predicting clinical outcome. The sum of this research will direct future therapies and management algorithms for this difficult disease.

PI_NAMEs: HOUPT, ERIC R (contact)

PROGRAM_OFFICER_NAME: MONGODIN, EMMANUEL FRANCK

PROJECT_TERMS: absorption;Address;Algorithms;Antibiotics;Applications Grants;Area;Bioinformatics;Biological Assay;Biology;Chimera organism;Clinical;clinical application;clinical sequencing;cohort;Collaborations;Data;Disease;drug development;Drug Kinetics;Drug Monitoring;Drug resistance;Drug Tolerance;Environment;Environmental Microbiology;Environmental Risk Factor;Epidemiology;evidence base;Exposure to;Future;genome sequencing;Genotype;Genus Mycobacterium;Health;Household;improved;In Vitro;in vivo;indexing;individual patient;Infection;Infection Control;innovation;innovative technologies;Lung Diseases;Measures;Microbial Biofilms;Modification;molecular diagnostics;Morbidity - disease rate;mortality;mycobacterial;Mycobacterium avium;Mycobacterium avium Complex;Mycobacterium intracellulare;non-tuberculosis mycobacteria;novel therapeutics;Organism;Outcome;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;Pharmacodynamics;pharmacokinetics and pharmacodynamics;Phenotype;predict clinical outcome;predictive marker;Predisposition;prognostication;programs;Regimen;Relapse;Request for Applications;Research;Resistance profile;Resolution;respiratory;Role;Sample Size;Serum;Source;Specimen;Sum;tool;Triage;United States National Institutes of Health;Universities;Virginia;Water;whole genome

PROJECT_TITLE: Mycobacterial Lung Diseases in Virginia: sequencing and clinical determinants of relapse and outcome

STUDY_SECTION: CRFS

STUDY_SECTION_NAME: Clinical Research and Field Studies of Infectious Diseases Study Section[CRFS]


NIH_SPENDING_CATS: Charcot-Marie-Tooth Disease;Neurodegenerative;Neurosciences;Peripheral Neuropathy;Rare Diseases

ORG_CITY: LOS ANGELES

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: Project Narrative Charcot-Marie-Tooth disease (CMT) is a hereditary neuropathy caused by gene mutations that lead to demyelination and axon degeneration of peripheral neurons. This proposal follows through on data suggesting that mutations in one of the CMT genes called Mfn2 affects mitochondrial fission and axonal transport in unexpected ways. A successful outcome of this project can provide new insight into the underlying causes of the disease and it may point the way towards developing novel treatment strategies.

PI_NAMEs: KOEHLER, CARLA M;VAN DER BLIEK, ALEXANDER M (contact)

PROGRAM_OFFICER_NAME: NUCKOLLS, GLEN H

PROJECT_TERMS: Affect;Apoptosis;Axon;axonal degeneration;Axonal Transport;Binding;Biochemical;Biological Assay;Biological Testing;Calcium;Carrier Proteins;Cell Line;Cells;Charcot-Marie-Tooth Disease;Chimeric Proteins;constriction;Data;Defect;Demyelinations;Disease;Dynamin;Experimental Designs;experimental study;Gene Deletion;Gene Mutation;Genes;genetic analysis;hereditary neuropathy;human disease;Imaging Techniques;Induction of Apoptosis;Inherited;Inner mitochondrial membrane;insight;Knock-out;knockout gene;Learning;Link;Mediating;Membrane;Membrane Fusion;Membrane Proteins;Metabolism;Microscopy;Mitochondria;Mitochondrial Matrix;Modeling;mutant;Mutation;Mycotoxins;Neurons;novel;OPA1 gene;Outcome;Outer Mitochondrial Membrane;Oxidative Phosphorylation;Patients;Peripheral;Peripheral Nervous System Diseases;Physiological;Play;Process;Proteins;Regulation;release of sequestered calcium ion into cytoplasm;Respiration;Role;Series;Signal Transduction Pathway;Site;Sodium;Spottings;Surface;Techniques;Testing;Transfection;treatment strategy;Zebrafish

PROJECT_TITLE: Control of calcium flux and mitochondrial fission by the Charcot Marie Tooth disease protein Mfn2.


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Coronaviruses;Gene Therapy;Genetics;Human Genome;Infectious Diseases;Rare Diseases

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative Viruses are a major threat to human health. The goal of our research is to dissect molecular mechanisms of how viruses replicate and invade the host cell or its genome. Overall, the studies proposed in this application will help better understand important human pathogens including cancer-causing retroviruses and coronaviruses to facilitate the development of new antiviral strategies.

PI_NAMEs: AIHARA, HIDEKI  (contact)

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TERMS: Antibodies;antiviral drug development;Area;Cells;Chromosomes;Complex;Coronavirus;Coronavirus spike protein;Development;Exoribonucleases;Gene Delivery;gene therapy;Genome;Goals;Health;Human;human pathogen;Human T-Cell Leukemia Viruses;Integration Host Factors;interest;Invaded;Laboratories;Life Cycle Stages;Malignant Neoplasms;Molecular;novel;receptor binding;Receptor Inhibition;Research;Retroviridae;RNA;Role;Rous sarcoma virus;small molecule;structural biology;Techniques;tool;Viral;Viral Genome;Viral Reverse Transcription;Virus;Virus Replication

PROJECT_TITLE: Structural studies of viral replication and invasion

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


NIH_SPENDING_CATS: Clinical Research;Contraception/Reproduction;Genetics;Human Genome;Nutrition;Pediatric;Women's Health Research

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Strassmann, BI Project Narrative Many diseases in adulthood have their origins in early development. This study will find out how the activity of genes in human placentas can transmit nutritional information from mothers to offspring. The purpose is to figure out some of the early pathways for a healthy start on life.

PI_NAMEs: STRASSMANN, BEVERLY ILSE (contact)

PROGRAM_OFFICER_NAME: MAJJI, SAI PRASANNA

PROJECT_TERMS: 5 year old;Address;Adult;Africa;Age;Alleles;Biological;Birth;Body mass index;Buttocks;Cessation of life;Characteristics;Childhood;cohort;Cohort Studies;Data;Data Set;Development;Disease;DNA;DNA Methylation;DNA Sequence;Education;Epigenetic Process;epigenetic regulation;Exons;Fatty acid glycerol esters;Fertilization;Gene Expression;Generations;Genes;genome-wide;Genomic Imprinting;Gestational Age;Growth;Growth and Development function;Head circumference;Health;Height;High-Throughput Nucleotide Sequencing;Human;imprint;improved;Individual;innovation;insight;inter-individual variation;interest;Length;Life;life history;Linear Regressions;Locomotion;low income country;Mali;Maps;Maternal Age;Measures;Menarche;Methylation;Modeling;mother nutrition;Mothers;Nutritional;offspring;Oocytes;Parents;parity;Pathway interactions;Phenotype;phenotypic data;Placenta;placental malaria;Play;Population;population based;Positioning Attribute;prepregnancy;Puberty;Quality Control;Reporting;Repression;Reproducibility;Research;Research Personnel;Resolution;Role;Sampling;sex;Techniques;Testing;Tissues;transcriptome sequencing;transmission process;Variant;Walking;Weaning;Weight

PROJECT_TITLE: Effect of genomic imprinting in placentas on maternal transmission of growth phenotypes to offspring in a multigenerational human cohort study

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-N(90)]


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Depression;Machine Learning and Artificial Intelligence;Major Depressive Disorder;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Neurosciences;Precision Medicine;Serious Mental Illness

ORG_CITY: PITTSBURGH

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: This is a K01 application designed to develop a data-driven machine learning model that will take into account several neural markers of response to Transcranial Magnetic Stimulation (TMS). The application proposes expanded training in machine learning optimization approaches and depression neurobiology for the applicant, who has a PhD in Bioengineering. The goal of the study is to identify stable, reproducible neural predictors of TMS treatment response to achieve clinically translatable personalized treatments, which matches the candidate’s long-term goal to conduct research on and develop models that personalize medicine for depression. 1

PI_NAMEs: KARIM, HELMET TALIB (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: Algorithms;Anterior;anti-depressive agents;archived data;Biological;biomarker identification;Biomedical Engineering;Brain;career;Clinical;clinical diagnosis;clinical translation;Clinical Treatment;cohort;Complex;Corpus striatum structure;cost;Data;Data Set;design;Development;Diagnostic;Doctor of Philosophy;electric field;executive function;experience;Goals;Heterogeneity;Individual;individual patient;large scale data;Left;Literature;Machine Learning;machine learning model;Major Depressive Disorder;Measures;Mental Depression;Modeling;Motor;neural;neural network;Neurobiology;neuroimaging;Neurosciences;Participant;Patients;personalized medicine;Placebo Effect;Positioning Attribute;predicting response;Prediction of Response to Therapy;predictive modeling;psychologic;random forest;Reproducibility;Research;response;response biomarker;Rest;Rewards;support vector machine;Testing;Time;Training;Transcranial magnetic stimulation;translational scientist;treatment response;Universities;voltage

PROJECT_TITLE: Machine Learning Models for Identifying Neural Predictors of TMS Treatment Response in MDD

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Cancer;Clinical Research;Neurosciences;Skin Cancer

ORG_CITY: ALBUQUERQUE

ORG_NAME: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR

ORG_STATE: NM

PHR: Melanoma brain metastasis (MBM) associates with high morbidity and mortality and is still extremely difficult to treat. An improved in-depth understanding of properties and mechanisms of brain-homing and brain-extruded Circulating Tumor Cells (CTCs) are urgently needed, and considered fundamental pre-requisites for the development of new and effective therapies targeting MBM.

PI_NAMEs: MARCHETTI, DARIO  (contact)

PROGRAM_OFFICER_NAME: YOUNG, MATTHEW R

PROJECT_TERMS: Affect;Astrocytes;Automobile Driving;Autopsy;Biological Assay;Biological Markers;biomarker development;Blood;Brain;cancer therapy;CD44 gene;Cell Line;Cell Proliferation;Cell Separation;Cell surface;Cells;Cerebrospinal Fluid;Clinical;clinical development;clinical predictors;Clinical Trials;cohort;combat;combinatorial;Complement;Country;Cytology;Dedications;Development;Diagnosis;Diagnostic;diagnostic value;Disease;drug discovery;Drug usage;effective therapy;Extracellular Matrix;Flow Cytometry;Fright;Gene Expression;Gene Expression Profiling;Goals;Growth;Heparan Sulfate Proteoglycan;heparanase;Heparanase inhibitors;Heparitin Sulfate;Homing;Human;improved;In Vitro;in vivo;Incidence;Invaded;Knowledge;Lead;Leptomeninges;Ligands;Link;Magnetic Resonance Imaging;Malignant Neoplasms;Mediating;Melanoma;Melanoma Cell;Melanoma patient;Metastatic malignant neoplasm to brain;Metastatic Melanoma;Modeling;Morbidity - disease rate;mortality;Neoplasm Circulating Cells;Neoplasm Metastasis;neoplastic cell;Nerve Growth Factor Receptors;Neurofibromatosis 2;Neurofibromin 2;Neuroglia;neurotrophic factor;NGFR Protein;novel;novel therapeutics;Oncogenic;PAK-1 kinase;Pathway interactions;Patient Isolation;Patients;Phenotype;Phosphorylation;Positioning Attribute;prevent;Prevention;Primary Neoplasm;Prognosis;prognostic;promoter;Property;Proteomics;Reporting;Role;Sampling;Selection for Treatments;Series;Signal Transduction;small molecule;syndecan;targeted biomarker;targeted treatment;Technology;Testing;Therapeutic;Therapeutic Effect;therapeutic target;Time;Tissues;tool;transcriptional coactivator p75;transcriptomics;tumor;Tumor Markers;Variant;Work;Xenograft procedure

PROJECT_TITLE: Mechanisms of melanoma brain metastasis by CTCs isolated from patients' blood and CSF

STUDY_SECTION: TPM

STUDY_SECTION_NAME: Tumor Progression and Metastasis Study Section[TPM]


NIH_SPENDING_CATS: Aging;Biotechnology

ORG_CITY: CHESTNUT HILL

ORG_NAME: BOSTON COLLEGE

PHR: Project Narrative We propose to develop chemical-proteomic platforms to investigate cysteine-oxidation events triggered by cellular reactive oxygen species. These methods will be applied to interrogate protein oxidation events that mediate cancer-cell proliferation upon growth-factor stimulation, and regulate lifespan in C. elegans.

PI_NAMEs: WEERAPANA, ERANTHIE  (contact)

PROGRAM_OFFICER_NAME: BARSKI, OLEG

PROJECT_TERMS: age related;Binding;Biotinylation;bropirimine;Caenorhabditis elegans;Cell Physiology;Cell Proliferation;Cells;cellular targeting;Chemicals;Cysteine;Disease;disulfide bond;Disulfides;Electron Transport;Epidermal Growth Factor;Epidermal Growth Factor Receptor;Event;extend lifespan;FABP5 gene;fatty acid-binding proteins;Generations;Growth Factor;Homeostasis;Hydrogen Peroxide;Label;life span;Light;Lipid Binding;Malignant Neoplasms;Mediating;Mediator;Methods;Mitochondria;mitochondrial dysfunction;Mitochondrial Proteins;Modification;mutant;NADPH Oxidase;Organelles;oxidation;Oxidation-Reduction;Property;Proteins;Proteomics;Reactive Oxygen Species;Role;Signal Pathway;Signal Transduction;SOD2 gene;spatiotemporal;Sulfenic Acids;Sulfhydryl Compounds;Sulfinic Acids;Sulfonic Acids;Superoxides;System;tool

PROJECT_TITLE: Developing chemical-proteomic tools to investigate cysteine oxidation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-G(55)R]


NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: NARRATIVE Meiosis is an evolutionarily conserved process by which a precursor cell is remodeled to produce gametes, which enable sexual reproduction. The proper execution of these cellular remodeling events is critical for production of viable gametes and is controlled by changes in which genes are turned on (expressed) at different stages of the process, although the specific regulation responsible has been unclear. My lab has recently defined the natural gene expression changes that occur during meiosis, discovering mysterious aspects to this regulation that defy expectations based on traditional models, and prompting important questions about how meiosis is regulated that we will now investigate.

PI_NAMEs: BRAR, GLORIA ANN (contact)

PROGRAM_OFFICER_NAME: MILLER, RITA K

PROJECT_TERMS: Case Study;Cell Physiology;Cells;Cellular Structures;Codon Nucleotides;Event;expectation;experimental study;Gene Expression;Gene Expression Regulation;Genes;genome annotation;Genomic approach;Germ Cells;Label;Meiosis;Messenger RNA;Metabolic;Modeling;Molecular;mRNA Transcript Degradation;Open Reading Frames;Organism;precursor cell;Process;Production;programs;Protein Isoforms;Proteins;Regulation;Reporter;Repression;Research;Role;Saccharomycetales;Sexual Reproduction;Structure;Time;Transcript;Translating;Translation Initiation;Translations;Work

PROJECT_TITLE: Illuminating the gene regulation underlying meiotic differentiation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-E(55)R]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science

ORG_CITY: PORTLAND

ORG_DEPT: NEUROLOGY

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Project Narrative Reducing health disparities requires a diverse biomedical workforce. This program provides research experience, skill-building activities, academic advising, and cultural immersion for trainees underrepresented in biomedical sciences to prepare them for successful pursuit and entry into a career in biomedical research.

PI_NAMEs: WESTBROOK, GARY L;WYATT, LETISHA RENEE (contact)

PROGRAM_OFFICER_NAME: AKACEM, LAMEESE DANA

PROJECT_TERMS: Academic advising;Address;Area;Articulation;Authorship;Biomedical Engineering;Biomedical Research;Cancer Biology;career;career development;college;Communication;Communities;Competence;Competency-Based Education;Critical Thinking;Data Analytics;data management;Dedications;Deposition;design;Development;Development Plans;Diverse Workforce;Doctor of Philosophy;Doctor's Degree;doctoral student;Educational workshop;Ensure;Environment;Ethics;evidence base;experience;Exposure to;Faculty;faculty mentor;Fostering;Funding;Goals;Graduate Degree;graduate school;graduate school preparation;graduate student;GRE Preparation;Health;health disparity;High School Student;Image;Immersion;Immunology;Individual;Informatics;Institution;Instruction;Interdisciplinary Study;interest;Interest Group;Joints;medical schools;meetings;Mentors;Mentorship;Neurosciences;novel;Oral;Oregon;Outcome;outreach program;Paper;Participant;peer coaching;Population;Postbaccalaureate;Postdoctoral Fellow;Preparation;Productivity;Professional Competence;Program Development;programs;Publications;recruit;Reduce health disparities;repository;Reproducibility;Research;research faculty;research in practice;Research Personnel;Research Project Grants;resilience;responsible research conduct;Rotation;Science;Self Efficacy;skill acquisition;skills;social organization;STEM field;Strategic Planning;Students;Study Skills;success;Techniques;Time;Time Management;Training;undergraduate student;Underrepresented Populations;Underrepresented Students;United States;Universities;Work;Writing

PROJECT_TITLE: OHSU PREP - Guiding Promising Underrepresented Post-Baccalaureates to be Successful Biomedical Scholars

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - D[TWD-D]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences;Pediatric

ORG_CITY: BALTIMORE

ORG_NAME: HUGO W. MOSER RES INST KENNEDY KRIEGER

ORG_STATE: MD

PHR: Project Narrative Social behavior deficits are common features of myriad psychiatric illnesses known to have roots in early development, including autism, schizophrenia and anxiety. Yet, there is little understanding of the ontogeny of social behavior in typically developing individuals. The proposedstudies are aimed towards dissecting the neural circuitry supporting flexible social behavior in typical and perturbed development.

PI_NAMEs: OPENDAK, MAYA  (contact)

PROGRAM_OFFICER_NAME: BREEDEN, ANDREW LEE

PROJECT_TERMS: Adaptive Behaviors;Adult;Age;age related;Amygdaloid structure;Animals;Anxiety;Area;autism spectrum disorder;Award;Behavior;behavior test;Behavioral;behavioral response;Brain;career;career development;Complex;Coupling;Data;Development;Development Plans;developmental neurobiology;dopaminergic neuron;effective therapy;Electrophysiology (science);ex vivo imaging;Exhibits;Fiber;flexibility;Food;Foundations;Frequencies;Goals;Growth;Imaging Techniques;Individual;Infant;Infant Behavior;innovation;insertion/deletion mutation;Laboratory Research;Lead;Life;Literature;Measures;Mental disorders;Mentors;Methodology;nerve supply;neural;neural circuit;neural network;neurobehavioral;Neurobiology;neurodevelopment;Neuronal Plasticity;neurophysiology;Neurophysiology - biologic function;Optics;optogenetics;Partner in relationship;Pathology;peer;pharmacologic;Phase;Photometry;postnatal;prevent;pup;Rattus;receptor;recruit;Research;Research Personnel;Research Project Grants;Research Proposals;Resources;Rodent;Role;Schizophrenia;skills;social;Social Behavior;Social Behavior Disorders;social bias;Social Development;Social Interaction;spatiotemporal;Stress;System;Techniques;Testing;Time;tool;Training;Trauma;Ventral Tegmental Area;Weaning;Work

PROJECT_TITLE: Neurobiology of Social Behavior: Circuit Analysis in Early Life

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Genetics

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Project narrative Humans have many unique features that distinguish them from other animals, ranging from behavior and social organization to susceptibility to infectious and chronic diseases. Elucidating the origin of these novelties is essential for understanding the genetic basis of human biology, individual variation, and health risk factors. The goal of this project is to reconstruct the molecular mechanisms of evolutionary innovations at all levels of biological organization, from new functional elements in the genome to new genetic pathways to new anatomical structures, using experimentally tractable animal models.

PI_NAMEs: KOPP, ARTYOM  (contact)

PROGRAM_OFFICER_NAME: ADKINS, RONALD

PROJECT_TERMS: Anatomy;Animal Model;Animals;Behavior;Biological;Biological Models;Cell Differentiation process;cell type;Chronic Disease;Communicable Diseases;Complex;DNA Sequence;Drosophila genus;Elements;Evolution;Gene Expression;Genes;Genetic;Genome;Goals;Health;Human;Human Biology;individual variation;innovation;Knowledge;Life;Modification;Molecular;Molecular Genetics;Morphology;Mutation;novel;Nutrient;Organ;Pathway interactions;Pattern;Planet Earth;Population;Predisposition;Regulatory Element;Regulatory Pathway;Research;Risk Factors;Series;Shapes;single molecule;social organization;Structure;Testing;Tissues;trait;Translating;Variant;Work

PROJECT_TITLE: Molecular Genetics of Evolutionary Innovations


ED_INST_TYPE: OVERALL MEDICAL

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Breast Cancer;Cancer;Clinical Research;Networking and Information Technology R&D (NITRD);Precision Medicine;Women's Health Research

PHR: Project Narrative This application proposes to validate the robustness of Shutter-Speed Model (SSM) dynamic contrast- enhanced (DCE) MRI as a quantitative imaging biomarker for assessment of cancer therapy response in a multicenter prospective study, using the setting of breast cancer response to neoadjuvant chemotherapy as the clinical test platform. Validation of this quantitative imaging method in a multi-site and multi-MR scanner platform setting and making the associated software tools publicly available will accelerate the translation into clinical trials and, ultimately, clinical practice to improve prediction and evaluation of cancer therapy response for individual patients in the emerging era of precision medicine.

PI_NAMEs: HOLMES, JAMES H;HUANG, WEI  (contact);PARTRIDGE, SAVANNAH CORRINA

PROGRAM_OFFICER_NAME: TATA, DARAYASH B

PROJECT_TERMS: Acceleration;Adjuvant Chemotherapy;Assessment tool;Benchmarking;Biological Process;Blood Vessels;Breast;Breast Cancer therapy;Breast Cancer Treatment;Breast Magnetic Resonance Imaging;Cancer Burden;cancer imaging;cancer therapy;cancer type;Cell membrane;Clinical;clinical application;Clinical Data;clinical decision support;Clinical Decision Support Systems;clinical decision-making;clinical practice;clinical translation;Clinical Trials;Computer software;contrast enhanced;Contrast Media;Data;data acquisition;Data Analyses;Data Set;Diffusion;Diffusion Magnetic Resonance Imaging;digital;Dimensions;Drug Kinetics;early phase clinical trial;Evaluation;Future;Goals;Head and Neck Cancer;Health;human data;Image;imaging biomarker;Imaging Device;imaging modality;improved;In complete remission;individual patient;individual response;Kinetics;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Neoplasms;Maps;Measurement;Measures;Metabolic;Methods;Modeling;molecular marker;MRI Scans;Multicenter Studies;Neoadjuvant Therapy;non-invasive imaging;Online Systems;Oregon;Outcome;Pathologic;patient subsets;Patients;Performance;Perfusion;Permeability;pharmacokinetic model;Physiological;precision medicine;predicting response;Prediction of Response to Therapy;predictive marker;predictive modeling;predictive tools;Procedures;prospective;Prospective Studies;Protocols documentation;quantitative imaging;Research;research clinical testing;Residual Cancers;response;Science;Signal Transduction;Site;Software Tools;Solid Neoplasm;Speed;System;Testing;Therapy Evaluation;Time;Tissues;Training;Translations;Treatment Protocols;treatment response;Treatment-related toxicity;tumor;Universities;Validation;Variant;Vendor;Water

PROJECT_TITLE: Multicenter Quantitative MRI Assessment of Breast Cancer Therapy Response

STUDY_SECTION: IGIS

STUDY_SECTION_NAME: Imaging Guided Interventions and Surgery Study Section[IGIS]


NIH_SPENDING_CATS: Attention Deficit Hyperactivity Disorder (ADHD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health

PHR: Project Narrative Attention deficit hyperactivity disorder (ADHD) is a condition in which functional impairments are observed at perceptual, cognitive, and motor levels, but few investigations have investigated how these functions relate to and influence each other. Using perceptual decision making paradigms, combined with high-resolution movement tracking, we will (1) investigate the extent movement improves timing deficits in adults with ADHD (and matched controls), and (2) assess how sensory information from multiple visual feature domains are combined to guide movement plans. These investigations present novel methods to probe integrated (i.e., perceptual, cognitive, and motor) performance in ADHD, and may inform the development of more comprehensive behavioral interventions by exploiting the link between movement and cognition.

PI_NAMEs: DE KOCK, ROSE V (contact)

PROGRAM_OFFICER_NAME: CORNELL, ASHLEY ROSE

PROJECT_TERMS: Adult;Affect;Area;Attention;Attention deficit hyperactivity disorder;Basic Science;Behavior;Behavior Therapy;Categories;Characteristics;Child;Clinical Psychology;Cognition;Cognitive;cognitive benefits;cognitive control;Cognitive deficits;cognitive function;cognitive load;cognitive process;Computer Models;Control Groups;Decision Making;Defect;design;Development;Diagnostic;Diffusion;Dimensions;Discrimination;discrimination task;Dissociation;Evaluation;executive function;Exhibits;experience;Foundations;Functional impairment;Future;Heterogeneity;Hyperactive behavior;Hyperactivity;Impairment;improved;Individual;information processing;innovation;insight;interest;Intervention;Investigation;Judgment;Knowledge;Laboratories;Link;Location;Maps;Methodology;Methods;Mind;Modeling;Motor;motor control;motor deficit;motor symptom;Movement;National Institute of Mental Health;Noise;novel;Participant;Pathway interactions;Perception;Performance;Persons;prevent;Process;Psychopathology;Quality of life;Reaction Time;Research;Resolution;Robotics;Sampling;Sensory;sensory integration;Sensory Process;Short-Term Memory;Signal Transduction;Source;spatiotemporal;Stimulus;stimulus processing;System;Testing;Therapeutic Intervention;Time;Time Perception;Uncertainty;Visual;visual stimulus;volunteer;Work

PROJECT_TITLE: Defining Embodied Characteristics of Decision Making in Attention Deficit Hyperactivity Disorder


NIH_SPENDING_CATS: Asthma;Biotechnology;Cardiovascular;Clinical Research;Contraception/Reproduction;Genetics;Human Genome;Hypertension;Lung;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Women's Health Research

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Project Narrative Preeclampsia (PE) causes maternal-fetal physiologic imbalance with maternal, fetal and neonatal morbidity and mortality. Maternal asthma also increases the risk of PE and childhood asthma. The genomic overlap of the two conditions could help to elucidate their early origins and potential prevention of both disorders and childhood asthma.

PI_NAMEs: MIRZAKHANI, HOOMAN  (contact)

PROGRAM_OFFICER_NAME: SHENOY, SIDDHARTH KAUP

PROJECT_TERMS: 25-hydroxyvitamin D;Academic Medical Centers;Achievement;Address;Affect;Age;antenatal;Asthma;asthmatic;Biological;Biological Markers;biomarker identification;biomedical informatics;Biometry;Blood;Blood specimen;Body mass index;career;Child;Childhood Asthma;circulating microRNA;Clinical;clinical practice;Clinical Research;Code;cohort;Comparative Genomic Analysis;Complex;Data;Development;developmental plasticity;differential expression;Disease;Doctor of Philosophy;early childhood;Early Diagnosis;early pregnancy;Epidemiology;Essential Genes;fetal;Future;gene environment interaction;Gene Expression;Genes;genetic signature;genomic data;genomic signature;Genomics;Goals;Grant;Health;high risk;High-Throughput Nucleotide Sequencing;Hospitals;Hypertension;immunoregulation;in utero;Inflammation;insight;instructor;interest;Investigation;Late pregnancy;Life;maternal condition;Maternal-Fetal Exchange;Maternal-fetal medicine;Measurement;Measures;Medical;medical schools;Medicine;Mentors;Messenger RNA;MicroRNAs;miRNA expression profiling;Molecular;Morbidity - disease rate;mortality;Mothers;multidisciplinary;Multiomic Data;neonatal morbidity;Neonatal Mortality;neonate;Netherlands;next generation sequencing;novel;offspring;pathophysiology of preeclampsia;Pathway interactions;peripheral blood;Pharmacogenetics;Pharmacogenomics;Phase;Physiological;Placenta;pre-clinical;Pre-Eclampsia;preclinical development;Pregnancy;pregnancy disorder;Pregnant Women;prenatal;prenatal risk factor;preservation;Prevalence;Prevention;prevention practice;Preventive;protein protein interaction;Records;Research;Research Personnel;respiratory;Risk;Risk Factors;RNA;Role;Sampling;Science;Scientist;Systems Biology;Time;Tissues;Training;transcriptome;transcriptomics;Translational Research;Translations;Umbilical Cord Blood;Validation;Vitamin D;Wheezing;Woman

PROJECT_TITLE: Integrative Longitudinal Genomics of Maternal Asthma-Preeclampsia Overlap and Risk of Childhood Asthma

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(OA)]


ADMINISTERING_IC: EB

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Clinical Research;Neurosciences;Pediatric

ORG_CITY: BLACKSBURG

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

PHR: PROJECT NARRATIVE The primary purpose of this project is to adapt and validate wearable, optically pumped magnetometer-based magnetoencephalography (opmMEG) methods to measure brain function in infants, and to then further adapt these protocols to simultaneously record brain function in mother-infant dyads during naturalistic interactions. This would represent the first application of wearable opmMEG in infants, as well as the first simultaneous opmMEG recordings from actively interacting mother-infant dyads. This work will lay the foundation for innovative, hypothesis-driven research aimed at understanding both how these dyadic neural patterns change during normative development, as well as how we can use this technology for identifying functional brain patterns that are indicative of emerging risk for developmental disorders in infants and postpartum psychopathology in mothers, allowing for early identification and intervention.

PI_NAMEs: HOWELL, BRITTANY ROLLINS (contact)

PROGRAM_OFFICER_NAME: WANG, SHUMIN

PROJECT_TERMS: Address;Adult;awake;Award;Behavior;Behavioral;Behavioral Paradigm;Brain;brain shape;Cementation;Characteristics;Child Development;clinically relevant;cost;Data;Data Collection;design;Development;developmental disease;Distress;dyadic interaction;Early identification;Early Intervention;Electroencephalography;Engineering;Event;Fostering;Foundations;Functional Magnetic Resonance Imaging;functional magnetic resonance imaging/electroencephalography;Future;Goals;Helmet;Human;Image;improved;infancy;Infant;innovation;Knowledge;Life;light weight;Loudness;Magnetoencephalography;Measures;method development;Methods;millisecond;Mothers;Motion;National Institute of Biomedical Imaging and Bioengineering;neural;neural patterning;neurobehavioral;neurodevelopment;neuroimaging;Neurophysiology - biologic function;Optics;Outcome;Participant;Pattern;Persons;Planets;Positioning Attribute;Postpartum Period;Procedures;programs;prospective;Protocols documentation;Psychopathology;Pump;Research;Research Personnel;Research Proposals;Resolution;response;Risk;Role;sensor;social;social deprivation;Social Interaction;source localization;Structure;success;System;Technology;Temperature;temporal measurement;Touch sensation;Virginia;wearable device;Work

PROJECT_TITLE: Developing wearable OPM-MEG to assess brain function in mother-infant dyads during social interactions


ORG_CITY: COLUMBIA

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

ORG_STATE: SC

PHR: Hypertension is a condition of premature vascular aging, where the normal decline in vascular function as we age is accelerated and exacerbated. It is well established that upregulation of autophagy can ameliorate this “aged” phenotype; however, underlying mechanisms are yet to be determined. Given that autophagy also serves to mobilize macro- and micronutrients in times of stress, we hypothesize that upregulation of autophagy in the liver, stimulates the production of ketone body, ? -hydroxybutyrate, which induces vasodilation, and decreases phenotypes of premature vascular aging associated with hypertension.

PI_NAMEs: MCCARTHY, CAMERON  (contact)

PROGRAM_OFFICER_NAME: OH, YOUNGSUK

PROJECT_TERMS: Acceleration;Age;age acceleration;age effect;aged;Aging;aging related;Anabolism;Angiotensin II;Anti-Hypertensive Agents;Aorta;arterial stiffness;Arteries;Autophagocytosis;beta-Hydroxybutyrate;Biological Availability;blood pressure reduction;Blood Vessels;calcium-activated potassium channel small-conductance;cardiovascular disorder risk;cardiovascular risk factor;Carotid Arteries;Catabolic Process;Chronic;Chronology;Clinical;Data;Deterioration;Development;Endothelial Cells;Endothelium;FFAR3 gene;Goals;Hepatic;Hepatocyte;Hydroxybutyrates;Hypertension;hypertensive;hypertensive factor;indexing;Infusion procedures;Intermittent fasting;ketogenesis;Ketone Bodies;lipid metabolism;Liver;Longevity;Mediator;Mesentery;Metabolism;Micronutrients;Mission;Morbidity - disease rate;mortality;Mus;Nitric Oxide;novel;novel therapeutics;Organelles;Pathogenicity;Patients;pharmacologic;Phase;Phenotype;Physiological;Potassium Channel;premature;pressure;prevent;Production;Proteins;Public Health;Rattus;receptor;reconstitution;Recycling;repaired;Resistance;response;Seminal;Signal Transduction;Starvation;Stress;System;Testing;Time;United States;United States National Institutes of Health;Up-Regulation;vascular bed;Vascular remodeling;Vasodilation;Waste Products

PROJECT_TITLE: Autophagy regulates β-hydroxybutyrate synthesis to prevent hypertension-associated premature vascular aging


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: AMHERST

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

PHR: Toxoplasma replication is the underlying mechanism by which this parasite causes severe and life-threatening disease. The work proposed here seeks to define how the parasite forms a structure called the inner membrane complex, which is analogous to its skeleton. Data from these studies will also identify novel drug targets.

PI_NAMEs: BLADER, IRA J (contact);WEST, CHRISTOPHER M.

PROGRAM_OFFICER_NAME: MCGUGAN, GLEN C

PROJECT_TERMS: 3-Dimensional;Antiparasitic Agents;Apical;Cell Maturation;Cell membrane;Cell Nucleus;Cells;Centrosome;Complex;Cullin Proteins;Cytokinesis;Cytoplasm;Data;Daughter;daughter cell;Defect;Development;Disease;F Box Domain;F-Box Proteins;Fetal Development;Future;Growth;Guanosine Triphosphate Phosphohydrolases;Immunocompromised Host;Interphase;Life;Membrane;Modeling;Mothers;Motility;Names;new therapeutic target;novel;oligomycin sensitivity-conferring protein;Organelles;Parasites;pathogen;Plasmodium;Process;protein complex;Proteins;Proteomics;Publishing;receptor;recruit;Research;Role;scaffold;screening;Skeleton;Structure;superresolution microscopy;Testing;Toxoplasma;Trimethoprim-Sulfamethoxazole;ubiquitin-protein ligase;Work

PROJECT_TITLE: The Organization and Function of the Toxoplasma Daughter Cell Scaffold

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDM-M(02)]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Cancer;Genetics;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: LARAMIE

ORG_NAME: UNIVERSITY OF WYOMING

ORG_STATE: WY

PHR: Project Narrative: Nuclear size is often deregulated in cancer cells, many cancers are diagnosed and staged based on graded increases in nuclear size, and little is known about the causes or effects of nuclear morphology changes in cancer. We will identify nuclear size effectors and elucidate mechanisms of nuclear size regulation, informing how nuclear size impacts embryonic development, cell differentiation, and carcinogenesis and shedding light on novel approaches and targets for the diagnosis and treatment of cancer. Aberrant nuclear size in cancer might actually be required for cell homeostasis and viability, so therapeutic manipulation of nuclear size could provide a means to selectively target and kill only affected cells.

PI_NAMEs: LEVY, DANIEL LEON (contact)

PROJECT_TERMS: Address;Affect;Biochemical;Biological;cancer cell;cancer diagnosis;cancer therapy;carcinogenesis;Cell Cycle;Cell Differentiation process;Cells;Chromatin Structure;Collaborations;Complement;Complex;Cytoplasm;Cytoskeletal Modeling;Development;Diagnosis;Diagnostic Neoplasm Staging;Disease;DNA Methylation;egg;Embryo;Embryonic Development;Encapsulated;experimental study;F-Actin;Growth;histone methylation;Histones;Homeostasis;human induced pluripotent stem cells;Image;In Vitro;in vivo;induced pluripotent stem cell;Knowledge;Lamins;Light;Malignant Neoplasms;Mammalian Cell;Microfluidics;Microscopy;Modification;Molecular Chaperones;Morphology;novel;novel strategies;Nuclear;Nuclear Envelope;Nuclear Import;Nuclear Lamin;Nuclear Lamina;Organelles;Pathologist;Ploidies;pluripotent stem cell differentiation;Productivity;Proteins;Proteomics;reconstitution;Regulation;Resolution;RNA interference screen;Screening Result;Shapes;Structural Protein;System;Techniques;Technology;Testing;Therapeutic;transcriptome sequencing;Vesicular Transport Proteins;Work;Xenopus;xenopus development

PROJECT_TITLE: Mechanisms of nuclear size regulation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


NIH_SPENDING_CATS: Biotechnology;Cancer;Colorectal Cancer;Complementary and Integrative Health;Digestive Diseases;Genetics;Immunotherapy;Natural Products

ORG_CITY: INDIANAPOLIS

ORG_DEPT: GENETICS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Project Narrative-Relevance to Public Health Reduction or loss of antigen presentation is a frequent and essential mechanism used by tumor cells to escape immune recognition and destruction. We identified atractylenolide I (ATT-I) in a screen of natural compounds from herbal medicine for colorectal cancer immunotherapy. We propose that ATT-I significantly promotes tumor antigen presentation of colorectal cancer cells and thereby enhances the efficacy of immune checkpoint blockade therapy.

PI_NAMEs: OPYRCHAL, MATEUSZ ;ZHANG, XINNA  (contact)

PROGRAM_OFFICER_NAME: XI, DAN

PROJECT_TERMS: 26S proteasome;Adoptive Cell Transfers;anti-PD1 antibodies;Antigen Presentation;Antigen Presentation Pathway;antigen processing;Antigens;antitumor effect;Architecture;Autologous;Bioinformatics;Biological Assay;Cancer Biology;cancer cell;cancer immunotherapy;cancer infiltrating T cells;Cancer Patient;cancer therapy;CD8-Positive T-Lymphocytes;cell mediated immune response;Cell-Mediated Cytolysis;Cells;Chemicals;Clinical;Coculture Techniques;Colon;colon cancer patients;Colon Carcinoma;Colonic Neoplasms;Colorectal Cancer;Colorectal Neoplasms;Complex;CTLA4 gene;cytotoxic;cytotoxic CD8 T cells;Cytotoxic T-Lymphocytes;cytotoxicity;Distal;empowerment;Event;Genes;Genetic Transcription;Genetically Engineered Mouse;Herbal Medicine;Histocompatibility;Human;Immune;immune cell infiltrate;immune checkpoint blockade;Immune checkpoint inhibitor;Immune response;Immune system;Immunology;Immunotherapy;Impairment;improved;KRASG12D;Legal patent;Macrophage;Malignant Neoplasms;Mass Spectrum Analysis;Mediating;Methods;MHC Class I Genes;Microsatellite Instability;Microsatellite Repeats;Modeling;Modeling of Functional Interactions;Molecular;Molecular Biology;Mus;Natural Compound;neoplastic cell;Organoids;Outcome;Patients;Peptides;Population;preservation;programmed cell death ligand 1;programmed cell death protein 1;Proteins;Protocols documentation;Public Health;Regulatory T-Lymphocyte;Research Personnel;Resistance;response;Sequence Deletion;single-cell RNA sequencing;small molecule;Solid Neoplasm;Stains;Standardization;structural biology;success;T-Cell Receptor;T-Lymphocyte;Testing;Therapeutic;Therapeutic antibodies;Therapeutic Intervention;tumor;Tumor Antigens;Tumor Escape;tumor immunology;tumor microenvironment;Tumor Promotion;Tumor Tissue;Tumor-infiltrating immune cells;Tumor-Infiltrating Lymphocytes;Ubiquitination

PROJECT_TITLE: Targeting immunoproteasome-mediated antigen presentation in colorectal cancer immunotherapy

STUDY_SECTION: CII

STUDY_SECTION_NAME: Cancer Immunopathology and Immunotherapy Study Section[CII]


ORG_CITY: DETROIT

ORG_DEPT: PHYSIOLOGY

ORG_NAME: WAYNE STATE UNIVERSITY

PHR: 8. PROJECT NARRATIVE The proposed research addresses the critical need to determine new molecular mechanisms that underlie how the heart relaxes, a key component of diastolic dysfunction and Heart Failure with preserved Ejection Fraction (HFpEF). We investigate a unique strain-rate (stretch) dependent mechanism to accelerate the relaxation of heart muscle. We utilize novel biomechanical tests to discover new drug targets and diagnostic indexes for diastolic dysfunction that can be translated into clinical practice.

PI_NAMEs: CHUNG, CHARLES S (contact)

PROGRAM_OFFICER_NAME: ADHIKARI, BISHOW B

PROJECT_TERMS: Acceleration;Actins;Acute;Address;arm;Attention;Attenuated;attenuation;Biochemical Process;biomechanical test;biophysical properties;Biophysics;Calcium;Cardiac;Catheterization;Clinical;clinical practice;clinically relevant;connectin;Contracts;Data;Dependence;Diagnosis;Diagnostic;Disease;EFRAC;Excision;experimental study;Filament;Fructose;Functional disorder;Goals;Head;Heart;Heart Diseases;Heart failure;hemodynamics;imaging biomarker;Impairment;improved;In Vitro;in vivo;indexing;Individual;Isometric Exercise;Kinetics;Length;Link;Mechanics;Mediating;Mediator;Methods;Modeling;Modification;Molecular;Motion;Myocardial;Myocardium;Myofibrils;Myosin ATPase;new therapeutic target;novel;Outcome Study;Patients;Peripheral Resistance;Pharmaceutical Preparations;pharmacologic;Physiological;Positioning Attribute;preservation;pressure;Property;Protein Isoforms;Rattus;Regulation;Relaxation;Research;response;Role;Sodium Chloride;Stretching;tau Proteins;Techniques;Testing;Thick Filament;Thin Filament;Tissues;Translating;Translations;ultrasound;Validation;Work;X ray diffraction analysis

PROJECT_TITLE: Leveraging Mechanical Control of Relaxation to Improve Diastolic Function

STUDY_SECTION: CCHF

STUDY_SECTION_NAME: Cardiac Contractility, Hypertrophy, and Failure Study Section[CCHF]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease;Prevention;Radiation Oncology

ORG_CITY: BUFFALO

ORG_NAME: ROSWELL PARK CANCER INSTITUTE CORP

PHR: PROJECT NARRATIVE  Despite the high incidence of debilitating coronary microvascular diseases in thoracic cancer survivors treated with ionizing radiation, no effective therapy is currently available. This interdisciplinary project will examine the effects and mechanisms of radiation-induced coronary endothelial and microvascular damage, and test the therapeutic utility of a novel liposome-stabilized peptide to counteract these effects.

PI_NAMEs: POKHAREL, SARASWATI  (contact)

PROJECT_TERMS: Achievement;Address;Birth;Blood flow;Blood Vessels;Bypass;Cancer Patient;cancer radiation therapy;Cancer Survivor;Cardiac;cardiac magnetic resonance imaging;cardioprotection;cell injury;Cells;Cessation of life;Chest;claudin-1 protein;Clinical;cohort;Coronary;Coronary artery;coronary fibrosis;Coronary Vessel Anomalies;Coronary Vessels;cytotoxic;Data;design;Development;Dose;Drug or chemical Tissue Distribution;effective therapy;Endothelial Cells;Endothelium;Engineering;Event;Extravasation;Fibrosis;fluorescence imaging;Formulation;Functional disorder;gain of function;Genes;Genetic;Genetic Transcription;Genetically Engineered Mouse;Goals;Half-Life;Heart;Heart failure;heart function;Hodgkin Disease;hypoperfusion;imaging approach;Impairment;improved;in vivo;Incidence;Injury;insight;Intervention;Ionizing radiation;Ions;irradiation;knock-down;Knowledge;Lead;Liposomes;loss of function;lysylproline;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of thorax;Malignant Neoplasms;Mediating;Microvascular Dysfunction;Modeling;Molecular;Molecular Biology;molecular imaging;mouse model;Mus;Muscle Cells;Myocardial;Myocardial Ischemia;Myocardial perfusion;nanoparticle;next generation;novel;novel therapeutics;Operative Surgical Procedures;Organ;overexpression;Pathologic;Peptides;Permeability;Pharmacotherapy;Porosity;Predisposition;preservation;prevent;Process;Property;protective effect;Protocols documentation;Radiation;radiation effect;Radiation exposure;radiation mitigation;Radiation therapy;reconstitution;Resistance;restoration;Rodent;Role;seal;Serum;siRNA delivery;Site;Small Interfering RNA;small molecule;solute;Stents;Structure;Technology;Testing;testing uptake;Therapeutic;therapeutic evaluation;thymosin beta(4);Tight Junctions;Tissues;tumor;uptake;Vascular Endothelial Cell;vascular injury;Vascular Permeabilities;water diffusion;Xenograft Model

PROJECT_TITLE: Inhibition of Radiation-Induced Coronary Microvascular Disease

STUDY_SECTION: MIM

STUDY_SECTION_NAME: Myocardial Ischemia and Metabolism Study Section[MIM]


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Chronic Pain;Dental, Oral, and Craniofacial Disease;Dietary Supplements;Genetics;Microbiome;Neurosciences;Pain Research;Temporomandibular Muscle/Joint Disorder (TMJD)

ORG_CITY: COLLEGE STATION

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR

ORG_STATE: TX

PHR: Project Narrative: In this project, we will reveal a specific epigenetic mechanism by which short-chain fatty acids (SCFAs) regulate chronic temporomandibular joint (TMJ) pain. The proposed studies will advance our understanding of the role of SCFAs in the epigenetic regulation of TMJ pain. Our long-term goal is to create a SCFA-based complementary non-opioid approach for treating TMJ pain and other chronic pain.

PI_NAMEs: TAO, FENG  (contact)

PROGRAM_OFFICER_NAME: GHIM, MELISSA M

PROJECT_TERMS: Acetic Acids;Address;Affect;Anti-Inflammatory Agents;Arthralgia;Butyric Acids;Carbohydrates;Chronic;chronic pain;Development;Epigenetic Process;epigenetic regulation;Facial Pain;fatty acid supplementation;fecal transplantation;Fermentation;Freund's Adjuvant;Genes;genetic manipulation;Genetic Transcription;Germ-Free;Glutamate Decarboxylase;Goals;gut bacteria;gut microbiome;gut microbiota;Health Personnel;Histone Acetylation;Histone Deacetylase;Histone Deacetylation;Inflammatory;Injections;innovation;Knockout Mice;Ligation;Maintenance;Masseter Muscle;Mediating;Medical;microbiome alteration;mouse model;Mus;Neurons;Nociception;non-opioid analgesic;Oral health;Pain;pain inhibition;Pathogenesis;Patients;Play;Promoter Regions;Property;Propionic Acids;Publishing;receptor;Regulation;Research;Resveratrol;Role;Signal Transduction;Structure of trigeminal nerve spinal tract nucleus;System;Temporomandibular Joint;Temporomandibular Joint Disorders;Tendon structure;Testing;Therapeutic Effect;Trigeminal System;Vagotomy;vagus nerve stimulation;Vagus nerve structure;Volatile Fatty Acids;Work

PROJECT_TITLE: Short-chain fatty acids and chronic temporomandibular joint pain

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Clinical Research;Genetics;Human Genome;Mental Health;Mental Illness;Schizophrenia;Serious Mental Illness

ORG_CITY: NEW YORK

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE Africa, the birthplace of modern humans, is the single most informative continent for understanding the human genome and human disorders with worldwide impact. Since most genomic research has not involved African populations, generations of human genetic history are missing from our understanding of human genetics and complex disease. In this study, we will use novel whole genome sequencing strategies to characterize the genetic bases of schizophrenia in the Xhosa population of South Africa.

PI_NAMEs: SUSSER, EZRA S. (contact)

PROGRAM_OFFICER_NAME: PEVSNER, JONATHAN ABRAM

PROJECT_TERMS: Africa;African;African ancestry;Age;Alleles;base;Binding;Blood;Brain;Cell Line;Code;Complex;Consent;Copy Number Polymorphism;Custom;Detection;Diagnosis;Disease;DNA Transposable Elements;Enhancers;Enrollment;experience;Gender;Generations;Genes;Genetic;genetic architecture;Genetic Diseases;Genetic study;Genetic Variation;genome sequencing;Genomic DNA;Genomics;Genotype;Goals;Grant;Human;Human Genetics;Human Genome;human genomics;human reference genome;Human Resources;Individual;Infrastructure;insertion/deletion mutation;International;international partnership;Link;Location;lymphoblast;Modeling;Modernization;Mutation;New York;novel;Participant;Phase;Phenotype;Point Mutation;Population;Privatization;Productivity;promoter;Protocols documentation;Recording of previous events;recruit;Regulatory Element;Research;Research Personnel;response;risk variant;Role;Sample Size;Sampling;Schizophrenia;Science;screening;Signal Transduction;Site;SNP array;South Africa;South African;Structure;study population;Synapses;synaptic function;Technology;Testing;transcription factor;Universities;Untranslated RNA;Variant;Washington;whole genome

PROJECT_TITLE: 2/3 Genomics of Schizophrenia in the South African Xhosa


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Rehabilitation;Stroke

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: NORTHEASTERN UNIVERSITY

PHR: Narrative This project will advance our empirical understanding of how dexterous updating of the upper limb, in particular reach-to-grasp actions, are orchestrated by the brain. The knowledge will be immediately applicable and translatable for rehabilitation of upper limb recovery in stroke and other similar disorders, by using error augmentation through visual and haptic platforms to facilitate skill reacquisition and identifying cortical targets for non-invasive neuromodulatory stimulation. These findings will be relevant to the mission of the NIH, with broad interest to clinicians and basic scientists, and will have direct public health relevance.

PI_NAMEs: ADAMOVICH, SERGEI V;TUNIK, EUGENE  (contact)

PROGRAM_OFFICER_NAME: CHEN, DAOFEN

PROJECT_TERMS: Anatomy;Anterior;Architecture;arm;arm movement;Behavior;Brain;Brain region;clinically relevant;Compensation;Complex;design;Digit structure;Disease;Dorsal;Exhibits;experience;flexibility;Goals;grasp;Hand;haptics;Individual;innovation;interest;intraparietal sulcus;Investigation;Knowledge;Limb structure;Location;Mechanics;Mediating;Mission;Modeling;Motion;Motor Cortex;Movement;movement analysis;neural;neuromechanism;neuromuscular;neurophysiology;neuroregulation;Parietal;Pathway interactions;Phase;Population;Posture;Procedures;Process;public health relevance;Recovery;Rehabilitation therapy;response;Robotics;Role;Scientist;Sensory;sensory feedback;Shapes;skills;Solid;Stroke;stroke intervention;System;Techniques;Testing;Thinking;Transcranial magnetic stimulation;United States National Institutes of Health;Update;Upper Extremity;Validation;virtual reality environment;Visual;Work

PROJECT_TITLE: Planning and Updating in Frontoparietal Networks for Grasping

STUDY_SECTION: MRS

STUDY_SECTION_NAME: Musculoskeletal Rehabilitation Sciences Study Section[MRS]


NIH_SPENDING_CATS: Clinical Research;Digestive Diseases;Food Allergies;Genetics;Human Genome

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: PROJECT NARRATIVE Eosinophilic esophagitis (EoE) is a chronic allergic disorder that begins in childhood and affects people of all ages. EoE is poorly understood, although it is known to be associated with allergic conditions. In this proposal, I will study how allergic signals change gene regulation in the epithelial lining of the esophagus and affect the esophageal mucosal barrier.

PI_NAMEs: RUFFNER, MELANIE A (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: 3-Dimensional;Affect;Age;Air;Allergens;Allergic;allergic airway inflammation;Automobile Driving;barrier to testing;Basal Cell Hyperplasia;Behavior;Bioinformatics;Biopsy;career;Cell division;Cell Physiology;Cells;chemokine;Chemotactic Factors;Childhood;ChIP-seq;chromatin immunoprecipitation;chromatin modification;Chronic;comparison control;cytokine;Data;dietary;Disease;DNA Sequence;Down-Regulation;Drug Targeting;Environment;eosinophil;Eosinophilic Esophagitis;Eosinophilic Infiltrate;eosinophilic inflammation;Epigenetic Process;epigenetic regulation;Epithelial Cells;Epithelium;Esophageal mucous membrane;Esophagus;experience;Exposure to;Flow Cytometry;Food Hypersensitivity;Foundations;Functional disorder;Future;Gene Expression;Gene Expression Profile;Gene Expression Regulation;Gene Proteins;Genes;Genetic Transcription;Genome;genomic locus;Goals;Growth;Heritability;Heterogeneity;Histologic;histone modification;Histones;Human;Immunofluorescence Immunologic;Impairment;improved;In Vitro;Inflammation;Inflammatory;Inflammatory Infiltrate;insight;Interleukin-13;Interleukin-4;Intracellular Space;Liquid substance;Mediating;Medical;Mentors;Microbe;microorganism antigen;Modeling;Modification;Morbidity - disease rate;Mucositis;Mucous Membrane;novel;Outcome Study;Pathogenesis;Pathway interactions;Patients;Persons;Phase;Phenotype;Play;Population;Positioning Attribute;Process;programs;protein expression;Proteins;Quantitative Reverse Transcriptase PCR;Regulatory Pathway;Reproducibility;Research;Research Personnel;Resolution;Risk;Role;Signal Pathway;Signal Transduction;single-cell RNA sequencing;skills;Squamous Differentiation;Squamous Epithelium;Structural Protein;Structure;Tight Junctions;Tissues;TLR2 gene;Training;transcription factor;transcriptome;transcriptomics;Translational Research;unsupervised clustering;Up-Regulation;Western Blotting;Work

PROJECT_TITLE: Epigenetic regulation of esophageal epithelial barrier function in eosinophilic esophagitis

STUDY_SECTION: AITC

STUDY_SECTION_NAME: Allergy, Immunology, and Transplantation Research Committee[AITC]


NIH_SPENDING_CATS: Bioengineering

ORG_CITY: Nashville

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: PROJECT NARRATIVE The dynamic microtubule cytoskeleton plays vital roles in cell division, motility and differentiation. This project aims to provide a fundamental molecular understanding of dynamic microtubule behavior using a multidisciplinary approach that combines biochemical in vitro reconstitution, live-cell imaging and computational modeling. Because microtubules are a common target for chemotherapeutic agents and many of their regulating proteins are implicated in cancer and neurodegenerative diseases, the proposed research bears critical relevance for both basic science and human health.

PI_NAMEs: ZANIC, MARIJA  (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TERMS: Basic Science;Behavior;Binding;Biochemical;Biophysics;Cell Differentiation process;Cell division;cell motility;Cell Physiology;Cells;chemotherapeutic agent;Computer Models;Cytoskeletal Modeling;Cytoskeleton;experience;experimental study;Feedback;Goals;Growth;Health;Human;human disease;in silico;In Vitro;Individual;insight;interdisciplinary approach;Investigation;Kinesin;light microscopy;live cell imaging;Long-Term Effects;Malignant Neoplasms;mathematical model;Measurement;Microfluidics;Microtubule Polymerization;Microtubules;Modeling;Molecular;Motility;Neurodegenerative Disorders;Neurodevelopmental Disorder;neuron development;Phase;Physiological;Play;Polymers;Process;protein purification;Proteins;reconstitution;Research;Resolution;Role;spatiotemporal;stathmin;Tertiary Protein Structure;Testing;Time;Tubulin;ultra high resolution

PROJECT_TITLE: Biophysical Principles of Microtubule Dynamics

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


ADMINISTERING_IC: AR

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: MADISON

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Project Narrative This project is relevant to public health because the outcomes could lead to the identification of targets for therapies that are aimed at preventing the loss of skeletal muscle mass that occurs during a variety of conditions such as bed rest, cachexia, muscular dystrophies, myopathies, immobilization, and aging.

PI_NAMEs: HORNBERGER, TROY A (contact)

PROGRAM_OFFICER_NAME: CARIFI, EMILY FORAN

PROJECT_TERMS: Aging;Bed rest;Biochemical;Biogenesis;Biopsy;Cachexia;Cell fusion;Cell Nucleus;Cell Proliferation;disorder prevention;Dissociation;Event;experimental study;Fiber;FRAP1 gene;Future;gene therapy;genetic corepressor;Genetic Transcription;Goals;Growth;Human;Hypertrophy;Immobilization;insight;Knockout Mice;LacZ Genes;Link;Maintenance;mechanical load;mechanical signal;Mechanical Stimulation;mechanical stimulus;Mechanics;Mediating;mimetics;Molecular;Mus;Muscle;muscle form;Muscle satellite cell;Muscular Dystrophies;mutant;Mutation;Myoblasts;Myopathy;novel;Outcome;Pathway interactions;phosphoproteomics;Phosphorylation;Phosphotransferases;Play;prevent;Process;Protein Biosynthesis;Public Health;Quality of life;Regulation;Reporting;Research;resistance exercise;response;Ribosomes;Role;Sampling;Scaffolding Protein;Serine;Signal Transduction;Skeletal Muscle;skeletal muscle wasting;targeted treatment;Testing;transcription factor;Transfection;Translating;Translations;TRIM Motif

PROJECT_TITLE: The Role of TRIM28 Phosphorylation in the Mechanical Regulation of Skeletal Muscle

STUDY_SECTION: SMEP

STUDY_SECTION_NAME: Skeletal Muscle and Exercise Physiology Study Section[SMEP]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Neurosciences

ORG_CITY: ATLANTA

ORG_DEPT: PSYCHOLOGY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Narrative The proposed research is relevant to public health because it develops better primate models of auditory cognitive processes critical for language in humans. By identifying shared components of auditory working memory, attentional control, and strategic decision-making in primates and humans, this work will enable researchers to use primates in basic and interventional studies. Thus, the proposed research is relevant to the part of the NIDCD’s mission that pertains to biomedical research on processing of speech and language.

PI_NAMEs: HAMPTON, ROBERT R (contact)

PROGRAM_OFFICER_NAME: POREMBA, AMY

PROJECT_TERMS: Address;Area;Attention;attentional control;attenuation;Auditory;auditory pathway;Behavioral Assay;Behavioral Model;Biomedical Research;Brain;Cognitive;cognitive ability;cognitive capacity;cognitive control;cognitive load;cognitive process;cognitive system;Communication;Communication impairment;Comparative Study;Complement;Data;Decision Making;Development;Diagnostic;Diagnostic tests;directed forgetting;Dissociation;Dorsal;dorsal visual stream;experimental study;flexibility;Foundations;Future;Goals;Hearing Tests;Human;human model;Individual;innovation;Instruction;Intervention;Intervention Studies;Language;language impairment;Link;Macaca mulatta;Maintenance;Memory;memory process;Mission;Modality;Modeling;Monkeys;National Institute on Deafness and Other Communication Disorders;neural;neuromechanism;nonhuman primate;novel;Outcome;Outcomes Research;Pongo pygmaeus;Primates;Process;Public Health;Reporting;Research;Research Personnel;Role;Short-Term Memory;skills;Speech;speech processing;Stream;System;Techniques;Testing;Training;Visual;Work

PROJECT_TITLE: Advancing primate models of human auditory cognitive control

STUDY_SECTION: HCMF

STUDY_SECTION_NAME: Human Complex Mental Function Study Section[HCMF]


NIH_SPENDING_CATS: Brain Disorders;Congenital Structural Anomalies;Neurosciences;Pediatric;Prevention;Rare Diseases;Spina Bifida;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

PHR: Project narrative Neural tube defects (NTDs) are among the most common serious birth defects diagnosed in human fetuses and newborns that result from the failure of neural tube closure during early pregnancy. We will determine the molecular and cellular mechanisms of neural activity during neural tube formation. The findings from this study will contribute to devising measures for the prevention of NTDs.

PI_NAMEs: BORODINSKY, LAURA NOEMI (contact)

PROGRAM_OFFICER_NAME: MORRIS, JILL A

PROJECT_TERMS: anti-epileptic agents;Brain;Brain Neoplasms;Calcium;Cell Cycle;Cell Cycle Progression;Cell Cycle Proteins;Cell Cycle Regulation;Cell Proliferation;Cell Shape;Cells;Congenital Abnormality;Data;Diagnosis;early pregnancy;Embryo;Environmental Risk Factor;Enzymes;Epilepsy;experimental study;extracellular;Failure;Fetus;gain of function;Genetic;Genetic Transcription;glutamatergic signaling;Glutamates;Goals;Human;Image;improved;in vivo imaging;Incidence;Incubated;innovation;Ion Channel;Knowledge;Lead;loss of function;Mainstreaming;Metabolic;Modeling;Molecular;nerve stem cell;Nervous System;nervous system development;neural;Neural Fold;neural plate;Neural tube;Neural Tube Closure;Neural Tube Defects;Neurodegenerative Disorders;Neurodevelopmental Disorder;neurogenesis;neuromechanism;Neurons;neuroregulation;Neurotransmitter Receptor;Neurotransmitters;Newborn Infant;novel;offspring;Patients;Pharmaceutical Preparations;pharmacologic;phosphoproteomics;Phosphorylation;Post-Translational Protein Processing;Pregnancy;Pregnant Women;Prevention Measures;Preventive measure;Proliferating;protein expression;protein function;Publishing;Reagent;Regulation;Reporter;Research;Research Design;Role;screening;sensor;Signal Transduction;spatiotemporal;Spinal Cord;spinal cord and brain injury;Statistical Data Interpretation;stem cell division;Testing;transcription factor;Valproic Acid;voltage;Xenopus laevis

PROJECT_TITLE: Mechanisms of neural activity during neural tube formation

STUDY_SECTION_NAME: Development - 2 Study Section[DEV2]


NIH_SPENDING_CATS: Cancer;Genetics;Immunotherapy

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

ORG_STATE: NY

PHR: PROJECT NARRATIVE CD8 T cells are powerful immune cells that specifically recognize infected cells, and in some settings cancer cells, and eliminate them. However, CD8 T cells in cancer patients fail to eliminate cancer cells because T cells become hyporesponsive. We propose to understand the mechanisms that drive T cells into cancer-induced hyporesponsiveness and test strategies to reprogram T cells into effective cancer killing immune cells.

PI_NAMEs: SCHIETINGER, ANDREA  (contact)

PROGRAM_OFFICER_NAME: LIU, YIN

PROJECT_TERMS: acute infection;Affinity;antigen-specific T cells;Antigens;Binding;cancer cell;cancer genetics;cancer immunotherapy;cancer infiltrating T cells;Cancer Model;Cancer Patient;carcinogenesis;CD8-Positive T-Lymphocytes;Cell Physiology;Cells;Chromatin;Chronic;chronic infection;clinically relevant;Data;design;DNA-Binding Proteins;Down-Regulation;Epigenetic Process;epigenomics;exhaust;exhaustion;Functional disorder;Genetic;genetic signature;Goals;Heterogeneity;Human;Immune;immune checkpoint blockade;Immunotherapeutic agent;Immunotherapy;imprint;improved;innovation;Maintenance;Major Histocompatibility Complex;Malignant Neoplasms;Mediating;Mediator;Methods;Molecular Profiling;mouse model;Mus;Nature;neoantigens;novel;patient subsets;Peptide Receptor;pharmacologic;Phenotype;Population;Population Heterogeneity;prevent;programs;protein degradation;receptor;Receptor Signaling;Repression;Resistance;Resources;Role;Signal Transduction;Specificity;T cell differentiation;T-Cell Activation;T-Cell Receptor;T-Lymphocyte;Testing;Therapeutic;Time;trait;transcription factor;transcriptomics;tumor;Tumor Antigens;Tumor-Infiltrating Lymphocytes;Work

PROJECT_TITLE: TOX-driven CD8 T cell differentiation and dysfunction in tumors