NIH_SPENDING_CATS: Bioengineering;Biotechnology;Clinical Research;Data Science;Drug Abuse (NIDA only);Genetics;HIV/AIDS;Human Genome;Microbiome;Networking and Information Technology R&D (NITRD);Neurosciences;Opioids;Precision Medicine;Stimulant Use and Misuse;Substance Misuse

PHR: Project Narrative - Computational Biology in Substance Use Core C Substances of abuse have a major impact on immunological, virological, gastrointestinal, and neurological outcomes associated with HIV disease progression, viral latency, and successful treatment. The complexity and multiplicity of the mechanisms associated with these effects requires the implementation of a comprehensive strategy to identify the mechanisms that lead to these defects. This core will develop and implement a holistic and unbiased analytical strategy that allows investigators in the CWRU Center of Excellence to identify mechanisms triggered by drug use that underlie these defects, thereby leading to the development of novel therapeutic approaches tailored to persons with substance use disorder and HIV.

PI_NAMEs: CHANCE, MARK R (contact)

PROJECT_TERMS: Address;Area;arm;Automobile Driving;bacterial community;Behavioral;Bioinformatics;Biological;Biological Assay;biomarker identification;biomarker validation;Biometry;Biomimetics;Blood - brain barrier anatomy;Body System;Cannabis;Cell model;Cells;Clinical;Cocaine;cohort;Color;complex data;Comprehensive Cancer Center;Computational Biology;computational pipelines;computing resources;Constipation;cytokine;Data;data acquisition;Data Analyses;data curation;data dissemination;data integration;data management;data platform;Data Set;Data Storage and Retrieval;Databases;Dedications;Defect;design;Development;Dimensions;Disease;Disease Progression;Doctor of Medicine;Doctor of Philosophy;drug testing;Drug usage;epigenome;Experimental Designs;Faculty;Fentanyl;Flow Cytometry;Functional disorder;Funding;gastrointestinal;gastrointestinal function;Genes;Genetic Transcription;Genomics;graduate student;gut dysbiosis;Health;Heroin;HIV;Homeostasis;Immune;Immune system;Immunologics;in vivo;Intestinal permeability;Knowledge;longitudinal analysis;Maps;Mass Spectrum Analysis;Measures;member;Meta-Analysis;Metabolism;metabolome;metabolomics;Methamphetamine;Methods;microbial;microbiome;Modeling;Molecular;Mucous Membrane;Multiomic Data;multiple omics;National Institute of Drug Abuse;Neurocognitive;Neurologic;Neurological outcome;new technology;novel therapeutic intervention;Opioid;Pathology;Pathway interactions;Patients;personalized approach;Persons;Pharmaceutical Preparations;Physiological;Plasma;Post-Translational Protein Processing;Postdoctoral Fellow;Preparation;professor;programs;Proteome;Proteomics;Protocols documentation;public database;Reporting;Research;Research Personnel;Research Support;Resolution;Resource Sharing;Resources;response;Risk;role model;Sampling;Services;Severity of illness;single-cell RNA sequencing;Small RNA;Source;Specimen;stem;Structure;Substance of Abuse;substance use;Substance Use Disorder;System;Technology;therapeutic development;Tissue Model;Tissues;Training;transcriptome sequencing;transcriptomics;Untranslated RNA;Viral;Virus Latency

PROJECT_TITLE: Research Support Core C: Computational Biology in Substance Use


ADMINISTERING_IC: DK

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Clinical Research;Digestive Diseases

ORG_CITY: PITTSBURGH

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE As the first comprehensive assessment of drug-induced pancreatic injury using modern epidemiologic and biostatistical techniques, the proposed research is relevant to public health because it is expected to identify which medications cause drug-induced pancreatic injury. This will directly impact post-pancreatitis medication management by reducing clinical uncertainty about which medications to stop to prevent recurrent pancreatitis and which essential medications to continue to treat patients’ other conditions. Furthermore, the proposed research is relevant to Scientific Goal 1 and Research Opportunity 2.4 of the 2021 NIDDK Strategic Plan because it will generate hypotheses about biologic and pharmacodynamic mechanisms of drug-induced pancreatic injury through novel data science techniques.

PI_NAMEs: VAJRAVELU, RAVY KUPPALAPALLE (contact)

PROGRAM_OFFICER_NAME: ANDERSEN, DANA K

PROJECT_TERMS: Accounting;acute pancreatitis;Address;Biological;Biometry;Case Study;Case/Control Studies;chronic pancreatitis;Classification;Clinical;clinical data warehouse;Clostridium difficile;Computers;Controlled Study;Dangerousness;Data;Data Analyses;Data Mart;Data Science;Databases;design;Dose;Drug Prescriptions;Electronic Health Record;Electronics;Epidemiology;Etiology;evidence base;Exhibits;experience;Exposure to;fundamental research;Future;gastrointestinal;Genomics;Goals;Health;Health Personnel;Hospitalization;improved;Incidence;Individual;individual patient;Infection;innovation;insight;interest;Label;Life Style;Linear Regressions;Logistic Regressions;Medical;Medication Management;Methodology;Methods;Modernization;National Institute of Diabetes and Digestive and Kidney Diseases;novel;Observational Study;Outcome;Pancreatic Injury;Pancreatitis;patient health information;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;Pharmacodynamics;Pharmacoepidemiology;pharmacologic;Pharmacopoeias;pilot test;post-market;prevent;Procedures;Public Health;Randomized, Controlled Trials;Recurrence;Reporting;Research;Research Design;Research Personnel;response;Retrospective cohort study;side effect;Specificity;Strategic Planning;Techniques;Time;time use;Uncertainty;United States;Update;usability;Veterans Health Administration

PROJECT_TITLE: Determining medications associated with drug-induced pancreatic injury through novel pharmacoepidemiology techniques that assess causation

STUDY_SECTION: KEDD

STUDY_SECTION_NAME: Kidney Endocrine and Digestive Disorders Study Section[KEDD]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Colorectal Cancer;Digestive Diseases;Nutrition;Patient Safety;Radiation Oncology

ORG_CITY: LOS ANGELES

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

ORG_STATE: CA

PHR: PROJECT NARRATIVE This prospective, two-parallel-arm, randomized controlled trial tests whether time-restricted eating (TRE; 8-hour eating/16-hour fasting) improves treatment-related toxicity, patient-reported adverse events and quality of life, and tumor regression (Aim 1) among rectal cancer patients compared to control (>12-hour eating). Aim 2 explores the underlying molecular mechanisms and tests whether these improvements are mediated through the IGF-1 pathway. Aim 3 examines whether mood, psychosocial functioning, daily activity, sleep and dietary intake moderate the relationships between intervention arms and clinical outcomes.

PI_NAMEs: FIGUEIREDO, JANE C. (contact);PETERSON, COURTNEY MARIE;SALVY, SARAH-JEANNE

PROGRAM_OFFICER_NAME: REEDY, JILL

PROJECT_TERMS: actigraphy;active method;Acute;Adverse effects;Adverse event;Affect;Aftercare;aged;Alabama;Animal Model;Animals;anti-cancer;Antioxidants;Anxiety;Apoptosis;arm;Autophagocytosis;Behavior;Behavioral;Blood Pressure;Body mass index;Caloric Restriction;cancer care;Cancer Patient;cancer regression;cancer therapy;cardiometabolism;CASP3 gene;Cell Death;cell growth;Cells;Characteristics;chemoradiation;chemotherapy;Chemotherapy and/or radiation;Clinical;clinical implementation;Clinical Trials;Common Terminology Criteria for Adverse Events;comparison control;Comprehensive Cancer Center;Counseling;cytotoxic;daily functioning;Data;Diagnosis;Diet;Dietary intake;Disease;DNA Damage;Eating;Enrollment;Equilibrium;ethnic diversity;European Organization for Research and Treatment of Cancer;Excision;Family;Fasting;Fatty acid glycerol esters;feasibility trial;Gamma-H2AX;Health;Heterogeneity;Hour;Human;Hunger;improved;In complete remission;indexing;innovation;insulin sensitivity;Intermittent fasting;Interview;Lead;Life;Life Style;Los Angeles;Malignant Neoplasms;Measures;Mediating;Medical;Medical center;men;Mental Depression;Molecular;Moods;neoplastic cell;Newly Diagnosed;nutrition;Oncology;Operative Surgical Procedures;Outcome;oxidation;Oxidative Stress;Participant;Pathologic;Pathway interactions;Patient Outcomes Assessments;Patient-Focused Outcomes;Patients;Peripheral Blood Mononuclear Cell;Physical activity;pilot trial;post intervention;predict clinical outcome;Proliferating;prospective;protein expression;psychosocial;Quality of life;Questionnaires;racial diversity;Randomized;Randomized, Controlled Trials;recruit;Rectal Cancer;Rectal Neoplasms;reduced food intake;Regimen;Reporting;Resistance;Risk;Schedule;Seminal;Serum;Shapes;Site;Sleep;social;Social Functioning;Somatomedins;standard of care;Stress;Structure;Symptoms;Testing;theories;Time;Time Study;Time-restricted feeding;Toxic effect;treatment arm;Treatment outcome;Treatment-related toxicity;tumor;Tumor Tissue;Universities;Weight;Woman;Work

PROJECT_TITLE: Time-Restricted Eating and Cancer: Clinical Outcomes, Mechanisms, and Moderators


ORG_CITY: MONTREAL

ORG_COUNTRY: CANADA

ORG_FIPS: CA

ORG_NAME: UNIVERSITY OF MONTREAL

ORG_STATE: PQ

ORG_ZIPCODE: H3C 3J7

PHR: Project Narrative The protein, eIF4E, is important to normal cells and when dysregulated can drive the development of a broad array of cancers. eIF4E does this by co-opting the signal from the DNA (known as RNA) allowing it to generate more of the proteins that can drive cancer. In this proposal, we identified a new mechanism by which eIF4E not only increases the protein-coding capacity of an RNA, but changes its structure, by subverting a process known as splicing. We can exploit this new knowledge to ultimately develop new therapeutic strategies for high-eIF4E cancers.

PI_NAMEs: BORDEN, KATHERINE L B (contact);GUZMAN, MONICA L

PROGRAM_OFFICER_NAME: MAAS, STEFAN

PROJECT_TERMS: Acute Myelocytic Leukemia;Alternative Splicing;Anti-viral Agents;Automobile Driving;Binding;Biochemical;Biological;Biological Models;burden of illness;Cancer Patient;cell type;Cells;Clinic;Code;Complex;Development;Disease remission;Dissection;DNA;Eukaryotic Initiation Factors;Event;Exhibits;extracellular;functional outcomes;Future;Geography;Goals;Guanosine;Head and Neck Cancer;head and neck cancer patient;improved;insight;Invaded;Knowledge;Malignant Neoplasms;malignant phenotype;MAP Kinase Gene;Mediating;Molds;Molecular;mouse model;Mutation;Nature;Neoplasm Metastasis;NF-kappa B;Normal Cell;novel;novel therapeutic intervention;novel therapeutics;Nuclear Export;Oncogenic;overexpression;Pathway interactions;Patients;Phase I Clinical Trials;Physiological;Play;Post-Transcriptional Regulation;Process;Production;programs;Proliferating;Prostate;Proteins;Regulon;response;Ribavirin;RNA;RNA Processing;RNA Splicing;Role;Signal Transduction;Spliceosomes;Structure;System;therapeutic target;Transcript;Translations;Work

PROJECT_TITLE: Molecular Mechanisms of eIF4E mediated transformation

STUDY_SECTION: CAMP

STUDY_SECTION_NAME: Cancer Molecular Pathobiology Study Section[CAMP]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Cancer;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Liver Cancer;Liver Disease;Microbiome;Nutrition;Prevention;Rare Diseases;Substance Misuse

ORG_CITY: IRVINE

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: Project Narrative Excessive consumption of fructose or alcohol causes fatty liver and occasionally liver cancer, but whether these two dietary risk factors synergistically induce liver cancer is unknown. In this proposal, we will determine how fructose intake alters liver handling of alcohol to increase liver cancer risk. To achieve this goal, we will employ state-of-the-art mass spectrometry and our newly generated genetically modified mice.

PI_NAMEs: JANG, CHOLSOON  (contact)

PROGRAM_OFFICER_NAME: MURRAY, GARY

PROJECT_TERMS: Acetate-CoA Ligase;Acetates;Acetyl Coenzyme A;Alcohol consumption;Alcoholism;Alcohols;Antibiotic Therapy;Antibiotics;Biochemical;Blood;cancer risk;cancer type;Carbon;carcinogenicity;Catabolism;Catalogs;Cause of Death;Charge;Chronic;Circulation;Cirrhosis;clinically relevant;colon microbiota;comparative;Consumption;Data;Development;diagnostic biomarker;dietary;dietary guidelines;drinking;Environment;Ethanol;Ethanol Metabolism;Event;Exposure to;Fatty acid glycerol esters;Fatty Liver;fatty liver disease;feeding;Feeds;Fructose;Gene Modified;Goals;gut microbiota;Hepatic;Histone Acetylation;in vivo;Incidence;Inflammatory;innovation;insight;Intake;knock-down;Leaky Gut;Liquid substance;Liver;liver inflammation;liver injury;Malignant neoplasm of liver;Malignant Neoplasms;Mass Spectrum Analysis;Measures;Mediating;Metabolic;Metabolism;metabolomics;Metagenomics;microbial;microbiota;microbiota metabolites;Molecular;mortality;mouse model;Mus;novel strategies;Oncogenic;Output;overexpression;Prevention strategy;Primary carcinoma of the liver cells;Production;Protocols documentation;Public Health;Risk;Risk Factors;soft drink;stable isotope;success;Techniques;Testing;tool;tumorigenic;Venous

PROJECT_TITLE: Elucidating dietary fructose and alcohol interactions during liver cancer development

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


ADMINISTERING_IC: DA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Emergency Care;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Opioids;Social Determinants of Health;Substance Misuse

ORG_CITY: CLEVELAND

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative - Clinical and Behavioral Services Core D Our understanding of the impact of substance use on HIV and those at-risk for HIV is limited by access to patients in this extremely vulnerable and marginalized population. The Clinical and Behavioral Services Research Support Core D’s activities will create, maintain, and expand a Clinical Database and Specimen Repository of this population to enable researchers the opportunity to complete translational investigations on difficult to reach and retain populations. The Clinical database, as well as their biological samples, will initially include HIV substance using individuals and then expand to include at-risk HIV negative substance using individuals.

PI_NAMEs: AVERY, ANN K (contact)

PROJECT_TERMS: Accident and Emergency department;addiction;AIDS prevention;Area;Back;Behavior Therapy;Behavioral;behavioral study;biobank;Biological;Biological Specimen Banks;Biopsy;Caring;Cerebrospinal Fluid;Characteristics;Client;Clinic;Clinical;Clinical Data;clinical database;Clinical Research;Clinical Trials;cohort;Collection;Colon;combat;Communicable Diseases;Community Healthcare;Community Outreach;County;County Hospitals;Data;Data Collection;data structure;Databases;design;Disease;Electronic Health Record;Emergency Department patient;epidemiology study;experience;Feces;Funding;Future;Health;health organization;Health Services Research;HIV;HIV Seronegativity;Hospitalization;Hospitals;implementation science;Indigent Care;Individual;Inpatients;Institution;Laboratories;Leadership;Link;Longitudinal cohort;marginalized population;Medical center;Medical Education;medical specialties;medication-assisted treatment;Mental Health;mental health organization;Mission;motivational enhancement therapy;Naloxone;National Institute of Drug Abuse;Needle-Exchange Programs;Nursing Research;Observational Study;Ohio;Opioid;opioid epidemic;Participant;Patient Care;Patient Outcomes Assessments;Patients;peer support;Peripheral Blood Mononuclear Cell;Persons;Plasma;Population;population health;pre-exposure prophylaxis;Primary Care;programs;Provider;Psychosocial Assessment and Care;Public Health;Recording of previous events;Recovery Support;recruit;Rectum;Registries;Reporting;repository;Research;Research Activity;Research Assistant;Research Personnel;Research Project Grants;Research Subjects;Research Support;Resources;Risk;RNA purification;Rural;Safety;sample collection;Sampling;screening;Serum;Services;Sexually Transmitted Diseases;Specimen;Suboxone;substance use;Substance Use Disorder;suburb;success;Swab;System;Teaching Hospitals;Time Study;Tonsillar Tissue;tool;Training;Translational Research;translational study;trauma centers;Universities;Urine;Vagina;virtual;Vulnerable Populations;waiver;Whole Blood

PROJECT_TITLE: Research Support Core D: Clinical and Behavioral Services


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Agent Orange & Dioxin;Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Endocrine Disruptors;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: PROJECT NARRATIVE The proposed research is relevant to the public health because craniofacial malformations, including cleft palate and congenital skull deformity, are among the most common birth defects. Our proposed study aims to improve the understanding how these craniofacial malformations occur and how the occurrence can be affected by environmental pollutants. Discovery from the study will help provide new strategies to prevent or decrease the risk of birth defects and inspire the development of novel therapeutic options.

PI_NAMEs: XU, JIAN  (contact)

PROGRAM_OFFICER_NAME: CHOU, ALICIA YESIU

PROJECT_TERMS: 3-Dimensional;Ablation;Affect;Animal Model;Area;Arginine;Aryl Hydrocarbon Receptor;Biochemical;Bioinformatics;Blood Vessels;bone loss;cell behavior;Cellular biology;ChIP-seq;Cleft Palate;cofactor;Complex;Congenital Abnormality;Connective Tissue;craniofacial;Craniofacial Abnormalities;craniofacial bone;craniofacial development;cranium;Cues;Cytoprotection;Defect;Deformity;Deposition;Development;Differentiation and Growth;Dioxins;DNA Binding;Elements;Environmental Pollutants;Environmental Risk Factor;Enzymes;Epigenetic Process;Exhibits;Face;gain of function;gene environment interaction;Gene Expression;gene induction;Genes;Genetic;Genetic Models;Genetic Predisposition to Disease;Genetic Transcription;Genomics;Growth;Head;high risk population;histone methylation;improved;Incidence;Investigation;Ligands;liver injury;loss of function;malformation;Mandible;Maps;Mediating;Methylation;Molecular;Morphogenesis;mouse genetics;Mus;Muscle;Nerve Tissue;Neural Crest Cell;non-histone protein;novel strategies;novel therapeutics;Nuclear Receptors;oxidative damage;palatal shelves;Palate;Pathway interactions;Predisposition;prevent;Prevention strategy;Primordium;Process;Protein Methylation;Protein-Arginine N-Methyltransferase;Public Health;pup;receptor;receptor binding;Repression;Research;response;Risk;Role;Stress;Structure;Tetrachlorodibenzodioxin;Toxic effect;Toxic Environmental Substances;Transcriptional Activation;transcriptome;transcriptome sequencing;Xenobiotics

PROJECT_TITLE: Protein methylation pathways that control genetic susceptibility to environmental pollutants in the occurrence of craniofacial defects

STUDY_SECTION: SBDD

STUDY_SECTION_NAME: Skeletal Biology Development and Disease Study Section[SBDD]


ADMINISTERING_IC: HD

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Physical Injury - Accidents and Adverse Effects;Prevention;Social Determinants of Health;Violence Research

ORG_CITY: SAINT LOUIS

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRIATIVE The cycle of violence is an under addressed public heath treat that disproportionately affects Black children and young adults in the United States (US) through the impact of structural and systemic racism. Life Outside Violence (LOV), the St. Louis region-wide hospital-based violence intervention program, is an individualized program that provides counseling and social- and case-based services to promote healing and prevent re- injury and death in patients who have presented to a LOV partner hospital with a violent injury. This project is a multi-center, mixed-methods study of barriers and facilitators of LOV enrollment informed by the social- ecologic model that uses community-based participatory research methods with an intervention mapping operational structure to design and assess an improved pathway to engage violently injured patients in the program.

PI_NAMEs: MUELLER, KRISTEN  (contact)

PROGRAM_OFFICER_NAME: MAHOLMES, VALERIE

PROJECT_TERMS: acceptability and feasibility;Accident and Emergency department;Address;Adult;Affect;Age;aged;Area;Award;black patient;Black race;career;career development;Caring;case-based;Cessation of life;Characteristics;Child;Childhood;clinical investigation;clinically relevant;Communities;community based participatory research;Counseling;Data;data repository;data sharing;Death Rate;design;Development;Development Plans;dissemination science;Education;Effectiveness;Electronic Mail;Elements;Eligibility Determination;Employment;Enrollment;Family;Firearms;Geography;Goals;Group Interviews;Gun injury;healing;Health;high risk;Hospitals;implementation barriers;implementation determinants;implementation facilitators;implementation science;improved;Incidence;Individual;Injury;injury prevention;innovation;Inpatients;insight;Institutional Racism;Intervention;intervention mapping;intervention program;Interview;K-Series Research Career Programs;Letters;Life;male;Master of Science;Medical;member;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Methods;Mission;Missouri;Modeling;Morbidity - disease rate;mortality;multilevel analysis;Murder;National Institute of Child Health and Human Development;Nonpenetrating Wounds;Not Hispanic or Latino;novel;Outcome;Participant;participant enrollment;partner violence;Pathway interactions;Patient Recruitments;Patients;Penetration;Persons;Pilot Projects;Positioning Attribute;preference;prevent;Program Evaluation;programs;prospective;Public Health;Recurrence;Reporting;Research;research and development;Research Design;Research Methodology;Research Personnel;Research Project Grants;research study;response;revictimization;Risk;Role;Sampling;scale up;service delivery;Services;skills;social;social health determinants;sociodemographics;Structural Racism;Structure;success;Telephone;Testing;Training;Training Programs;transition to adulthood;Trauma;Traumatic injury;United States;Universities;Violence;violence prevention;violent crime;Violent injury;ward;Washington;young adult

PROJECT_TITLE: Spreading LOV: Developing a Plan to Improve Engagement in the Life Outside Violence Program

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Health, Behavior, and Context Study Section[CHHD-M]


NIH_SPENDING_CATS: Clinical Research;Drug Abuse (NIDA only);HIV/AIDS;Substance Misuse

PHR: Project Narrative – Pilot Research Project Core E Substance use remains the second most common mode of exposure to HIV among infected individuals nationwide, representing 31% of total diagnoses. In addition, substance use is associated with a more severe course of HIV disease as shown by poor immune reconstitution and increased rate of co-morbidities. This core provides financial support, mentoring, and training for junior and under-represented minority faculty working in this arena.

PI_NAMEs: LEVINE, ALAN DAVID (contact)

PROJECT_TERMS: Acceleration;Award;Basic Science;Behavioral;career;career development;Clinical Sciences;community engagement;comorbidity;Consultations;design;Development;Diagnosis;Discipline;Disease;Educational workshop;Ensure;Ethics;experience;Exposure to;Faculty;Financial Support;Funding;Grant;Growth;HIV;immune reconstitution;Individual;Informed Consent;innovation;Institution;instructor;Investments;Link;medical schools;Medicine;member;Mental Health;Mentors;multidisciplinary;National Institute of Drug Abuse;next generation;Participant;participant retention;Patient Recruitments;peer;peer coaching;Persons;Pilot Projects;Procedures;professor;programs;Reproducibility;Research;Research Activity;Research Design;Research Methodology;Research Personnel;Research Project Grants;Resources;responsible research conduct;retention rate;Review Committee;Role;Scientist;senior faculty;Series;Services;sound;substance use;synergism;Teacher Professional Development;Training;Training Activity;Translational Research;Travel;Underrepresented Minority;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Pilot Research Project Core E


NIH_SPENDING_CATS: Biotechnology;Genetics;Hematology;Human Genome;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

PHR: NARRATIVE The proposed work focuses on understanding basic cellular and molecular mechanisms that underlie the production and function of blood cells; specifically in regulating the production and terminal development of blood cells (hematopoiesis), regulating the expression of genes relevant to normal blood-cell maturation and function, and defining regulatory molecules that influence blood cell production from hematopoietic stem cells and progenitors. Broad community access to these deliverables will to accelerate scientific progress in understanding, treatment and prevention of diseases.

PI_NAMEs: GRIMES, H. LEIGHTON (contact)

PROGRAM_OFFICER_NAME: HATTANGADI, SHILPA MANOHAR

PROJECT_TERMS: Acceleration;Address;Adoptive Transfer;analytical method;Antibodies;Architecture;Bar Codes;bioinformatics pipeline;bioinformatics tool;Biological;Biological Assay;Blood Cells;Bone Marrow;Catalogs;Cell Maturation;Cell Physiology;Cell surface;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Chromatin;Collaborations;Colony-Forming Units Assay;Communities;computer framework;computerized tools;Confusion;Coupled;Data Set;Development;Disease;disorder prevention;Dissection;Elements;Enhancers;Explosion;Flow Cytometry;functional genomics;Gene Expression;gene regulatory network;Genes;Genetic;Genetic Transcription;genomic data;Genomics;Health;Hematologist;Hematopoiesis;Hematopoietic;Hematopoietic Cell Production;Hematopoietic stem cells;Hematopoietic System;Heterogeneity;Hi-C;Human;Impairment;In Vitro;in vivo;indexing;insight;Interdisciplinary Study;Link;Macrophage;Methods;microscopic imaging;Molecular;Multipotent Stem Cells;Mus;Myelogenous;Myeloid Cells;neutrophil;Oligonucleotides;online resource;Outcome;Population;Production;progenitor;programs;promoter;Reporter;self-renewal;single cell ATAC-seq;single cell genomics;single cell technology;single-cell RNA sequencing;Sorting;Specific qualifier value;stem cell fate specification;stem cell population;System;Systems Biology;Testing;tool;transcription factor;transcriptome;Transplantation;Validation;Work

PROJECT_TITLE: A generalizable framework for linking single-cell genomic states with cell fate outcomes in hematopoiesis


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Clinical Research

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PI_NAMEs: HOLMES, JAMES F. (contact)

PROGRAM_OFFICER_NAME: RADMAN, THOMAS C

PROJECT_TERMS: Address;Area;Awareness;Biological Sciences;career;career development;Center for Translational Science Activities;Clinical;Clinical Investigator;Clinical Sciences;cohort;Collaborations;Communities;Complex;Development;Discipline;Diverse Workforce;early-career faculty;Education;education research;effectiveness testing;Ensure;Extramural Activities;faculty support;Fostering;Foundations;Funding;Goals;Grant;Health;Healthcare;Human;Industry;Institution;Intervention;Knowledge;Leadership;Mentors;Mission;multidisciplinary;Persons;Positioning Attribute;Program Development;programs;Randomized, Controlled Trials;recruit;Research;Research Personnel;Research Training;Resources;Science;skills;Special needs;Speed;success;synergism;Teacher Professional Development;tool;Training;Translational Research;translational scientist;Underrepresented Populations;Universities;Videoconferencing

PROJECT_TITLE: Institutional Career Development Core (KL2)


ADMINISTERING_IC: HL

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Genetics;Heart Disease;Human Genome;Regenerative Medicine

ORG_CITY: MADISON

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE My proposed studies will elucidate the molecular mechanisms by which activation and repression dually ensure precise cardiac regeneration enhancer activity in uninjured and regenerating hearts. My studies also seek to identify novel cardiac regeneration enhancers in the genomes of zebrafish, mice, and humans, which will reveal how cardiac regeneration enhancer activity and regulation have evolved across regenerative and non- regenerative species. These studies will utilize genetic tools and the endogenous regenerative ability of the zebrafish heart to elucidate transcriptional mechanisms underlying heart regeneration and identify potential targets for improving heart repair in mammals.

PI_NAMEs: BEGEMAN, IAN  (contact)

PROGRAM_OFFICER_NAME: HUANG, LI-SHIN

PROJECT_TERMS: Adult;ATAC-seq;Bar Codes;Binding;Binding Sites;Biological Assay;Cardiac;Cardiac Myocytes;cardiac regeneration;cardiac repair;cell regeneration;Cells;ChIP-seq;Chromatin;Cicatrix;Complex;Computer Analysis;Conserved Sequence;CRISPR/Cas technology;Data;Deposition;Elements;Endocardium;Enhancers;Ensure;epigenomics;Failure;Fishes;Future;Gene Expression;gene regulatory network;Genes;Genetic;genetic approach;Genetic Transcription;Heart;Heart failure;Heart Injuries;Histones;Homologous Gene;Human;Human Genome;improved;in vivo;inhibitor;injured;Injury;Leptin;Link;loss of function;Mammals;MAP2K1 gene;MAPK3 gene;Mediating;MEK inhibition;MEKs;Modeling;Molecular;mouse genome;Mus;Mutate;Mutation Analysis;Myocardial Infarction;Natural regeneration;novel;paracrine;Pathway interactions;pharmacologic;prevent;programs;Proliferating;regenerative;Regulation;Reporter Genes;Repression;Research;Residual state;Resolution;response;Role;SET Domain;Signal Pathway;Signal Transduction;Sorting;spatiotemporal;Sudden Death;Testing;Therapeutic;Tissues;tool;Transcription Factor AP-1;Transcription Repressor;transcriptome sequencing;Transgenic Organisms;Zebrafish;zebrafish genome

PROJECT_TITLE: Dissecting Regulatory Mechanisms of Cardiac Regeneration Enhancers


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics

ORG_CITY: PHILADELPHIA

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative Some genetic diseases result not because cells make a defective protein component, but rather because they don’t make enough of the component. We have identified a widely applicable, targeted approach to induce cells to increase the protein output from a single ‘good’ copy of a gene. We aim to define all such clinically relevant targets, and to apply our existing knowledge to a mouse model of specific, incurable, fatal disease called pulmonary arterial hypertension.

PI_NAMEs: BARASH, YOSEPH  (contact);HAND, NICHOLAS JOSEPH

PROGRAM_OFFICER_NAME: YU, GUOQIN

PROJECT_TERMS: 5' Untranslated Regions;Affect;Animal Model;Animals;Antisense Oligonucleotides;Back;biobank;Biological Assay;Biology;BMPR2 gene;Cell Culture Techniques;Cells;clinically relevant;Code;Communities;computational pipelines;Computer Models;Coupled;Data;Data Set;Databases;design;Disease;disease phenotype;dosage;Dose;Enzyme-Linked Immunosorbent Assay;Evolution;Exhibits;experimental study;Future;Gene Proteins;Genes;Genetic;Genetic Databases;Genetic Diseases;genetic variant;Genomics;Goals;Grant;Hereditary Disease;Heritability;Human;improved;in vivo;in vivo evaluation;Initiator Codon;Intervention;Knowledge;Luciferases;Maps;Measures;Messenger RNA;Modeling;Molecular Biology;mouse model;Mus;Mutate;novel;Open Reading Frames;Output;Pathway interactions;Patients;Peptides;Phenotype;preservation;protein expression;Proteins;Publishing;pulmonary arterial hypertension;Pulmonary artery structure;Regulatory Element;Reporter;Resources;Rest;ribosome profiling;RNA;RNA Processing;Role;Signal Pathway;targeted treatment;Terminator Codon;Testing;Therapeutic;Therapeutic Intervention;translational approach;translational potential;Translations;user-friendly;Validation;Variant;web-based tool;Work

PROJECT_TITLE: Identifying regulatory uORFs as a targetable axis for hereditary disease

STUDY_SECTION: TAG

STUDY_SECTION_NAME: Therapeutic Approaches to Genetic Diseases Study Section[TAG]


ADMINISTERING_IC: EY

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Eye Disease and Disorders of Vision;Nanotechnology;Neurosciences

ORG_CITY: ITHACA

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CORNELL UNIVERSITY

ORG_STATE: NY

PHR: Project Narrative The phototransduction pathway in retinal rods is a highly amplified GPCR (rhodopsin)-coupled signaling pathway responsible for vision in dim light. The loss of the proper regulation for the coupling of rhodopsin to its G-protein partner transducin, or in the subsequent stimulation of the cyclic GMP phosphodiesterase by activated transducin-a, has been linked to retinal degeneration and various eye diseases. We propose to learn more about the proper functioning of these critically important signaling steps with the ultimate goal of identifying new therapeutic strategies against these vision disorders, as well as gain fundamental insights into other GPCR-dependent sensory response pathways that have clinical relevance.

PI_NAMEs: CERIONE, RICHARD A. (contact)

PROGRAM_OFFICER_NAME: NEUHOLD, LISA

PROJECT_TERMS: 3-Dimensional;absorption;Address;alpha Subunit Transducin;Antibodies;Binding;Biochemical;Biological;Biological Assay;C-terminal;Catalysis;Catalytic Domain;clinically relevant;Complex;Coupled;Coupling;Cryoelectron Microscopy;Cyclic GMP;design;Disease;Electron Spin Resonance Spectroscopy;Environment;Enzymes;Eye diseases;Fluorescence;Fluorescence Resonance Energy Transfer;G-Protein Signaling Pathway;G-Protein-Coupled Receptors;Goals;GTP Binding;GTP-Binding Proteins;Guanosine Triphosphate;Heterotrimeric GTP-Binding Proteins;insight;Ion Channel Gating;Label;Laboratories;Learning;Light;Link;Liposomes;Membrane;Membrane Lipids;Modeling;Molecular Probes;Monitor;nanodisk;Noise;novel;novel therapeutic intervention;Optic Nerve;Output;Pathway interactions;phosphodiesterase 6;phosphoric diester hydrolase;Photons;Photoreceptors;Phototransduction;Physiologic pulse;Physiological;Play;Proteins;reconstitution;Regulation;response;Retina;Retinal Degeneration;retinal rods;Rhodopsin;Rod Outer Segments;Role;Sensory;Sensory Receptors;Signal Pathway;Signal Transduction;Site;Structure;System;Testing;three dimensional structure;Time;Transducin;Vision;Vision Disorders;Work

PROJECT_TITLE: Probing the molecular mechanisms that regulate key steps in the GPCR-sensory response pathway responsible for vision in dim light

STUDY_SECTION: BBM

STUDY_SECTION_NAME: Biochemistry and Biophysics of Membranes Study Section[BBM]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Microbiome;Nutrition;Obesity

ORG_CITY: FARMINGTON

ORG_NAME: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT

ORG_STATE: CT

PHR: Aging and age-related metabolic dysfunction poses unprecedented challenge to public health, and development of innovative and targetable interventions is highly warranted. Our project will examine the interplay of the microbiome and cellular senescence underlying diet-induced metabolic dysfunction in mice with older age. It will offer an integrative understanding of pathophysiology of age-related diseases, and lay a solid foundation to develop robust interventions targeting senescence, microbiome or both to improve health and increase longevity.

PI_NAMEs: XU, MING ;ZHOU, YANJIAO  (contact)

PROGRAM_OFFICER_NAME: FLORES, ROBERTO L

PROJECT_TERMS: Adipocytes;Affect;age effect;age related;age related chronic disease;age-related disease;Aging;aging related;Agreement;anti aging;Anti-Inflammatory Agents;Attenuated;Bacteria;Caloric Restriction;Cell Aging;cell growth regulation;Cell Proliferation;cell type;Cells;Colon;Development;Diet;Dietary Intervention;Disease;Exhibits;fecal microbiota;fecal transplantation;Female;Fortification;Foundations;Functional disorder;Gene Expression;Genetic;Goals;Gram-Negative Bacteria;gut bacteria;gut microbiome;gut microbiota;Health;High Fat Diet;Human;human old age (65+);immune activation;improved;In Vitro;in vitro Assay;in vivo;Inflammation;Inflammatory;innovation;insight;Insulin Resistance;Intermittent fasting;Intervention;life span;Lipopolysaccharides;Literature;Longevity;male;Mediating;Metabolic;Metabolic Control;Metabolic Diseases;Metabolic dysfunction;Metabolic stress;metabolome;Metagenomics;Microbe;microbial;microbial composition;microbiome;microbiome alteration;microbiome composition;microbiota;microbiota transplantation;mouse model;Mucous Membrane;Mus;novel;novel therapeutics;Obesity;old mice;Pattern;Physiological Processes;Play;Population;Production;Progeria;Property;Proteobacteria;Public Health;Research;Role;Sample Size;senescence;senescence associated secretory phenotype;senescent cell;Shotgun Sequencing;Solid;Testing;Tissues;Transgenic Mice;Transplantation

PROJECT_TITLE: Reciprocal Modulation of the Microbiome and Cellular Senescence in Metabolic Dysfunction


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Data Science;Emerging Infectious Diseases;Infectious Diseases;Networking and Information Technology R&D (NITRD)

ORG_CITY: BIRMINGHAM

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE This proposed effort will develop, enable access to, and substantially improve information on viruses from the perspective of their evolutionary relationships and taxonomy. It will provide the infrastructure needed to deliver that information, advancing the capacity of bench scientists, computer scientists, educators, trade regulators, pharmaceutical firms, government agencies, policy makers, and the general public to conduct leading edge research, mitigate the threat posed by virus disease, and better understand the risks posed by viruses to human, animal, and agricultural health. This work will also contribute to national and international security by helping governments to respond to unforeseen outbreaks of virus diseases such as COVID-19.

PI_NAMEs: LEFKOWITZ, ELLIOT J. (contact)

PROGRAM_OFFICER_NAME: SASTALLA, INKA I

PROJECT_TITLE: Virus Taxonomy: A Community Knowledgebase Supporting Virus Research

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-T(55)R]


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Clinical Research;Kidney Disease

ORG_CITY: SEATTLE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative The proposed research is expected to define the pathways of metabolism and transport of the widely used disinfectant, benzalkonium chlorides, and elucidate interactions between the metabolism and transport capacity and toxicity of BACs in vitro and in humans. This project relates to NIH’s goals in understanding biological effects of environmental contaminants and prevention and cure of human diseases.

PI_NAMEs: XU, LIBIN  (contact)

PROGRAM_OFFICER_NAME: CARLIN, DANIELLE J

PROJECT_TERMS: 3-Dimensional;ABCB1 gene;absorption;Active Biological Transport;Address;Affect;antimicrobial;Benzalkonium Chloride;Bile Acids;Biological;Biological Markers;biomarker identification;Blood;Carboxylic Acids;Carrier Proteins;Case Study;Cell Death;cell injury;Cell Line;Cells;Cholesterol;Chronic;Complement;consumer product;COVID-19 pandemic;CYP2D6 gene;Cytochrome P450;cytotoxicity;Data;Dermal;Development;Disinfectants;Environmental Pollutants;Epithelial Cells;experimental study;Exposure to;Food processing industry;gene environment interaction;Gene Expression;Genetic Variation;Goals;Healthcare;Hepatocyte;high risk;Homeostasis;Human;human disease;Hydroxylation;In Vitro;Ingestion;Inhalation;inhibitor;Injury to Kidney;innovation;Intake;Kidney;kidney cell;Knowledge;lipid metabolism;lipidomics;Lipids;Liver;Local Anti-Infective Agents;Medical;Metabolic;Metabolism;microphysiology system;Mus;nephrotoxicity;Neurologic;novel;Oral;Oral Ingestion;Organ;organ on a chip;Organic Cation Transporter;Outcome;oxidation;Participant;Pathway interactions;Pharmaceutical Preparations;Phase;Plasma;Population;Prevention;Protein Isoforms;Proteins;Proximal Kidney Tubules;Rattus;Reporting;reproductive;Research;respiratory;Rodent;Route;Safety;Sampling;Side;Sterols;stool sample;System;Testing;Time;Tissues;Toxic effect;Toxicology;Toxin;transcriptome sequencing;transcriptomics;Transfection;United States National Institutes of Health;uptake;Urine;Work;Xenobiotics

PROJECT_TITLE: Interactions between metabolism, transport, and toxicity of benzalkonium chlorides

STUDY_SECTION: SIEE

STUDY_SECTION_NAME: Systemic Injury by Environmental Exposure[SIEE]


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Genetic Testing;Genetics;Prevention;Urologic Diseases

ORG_CITY: BALTIMORE

ORG_DEPT: PATHOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Narrative Bladder cancer is the sixth most common cancer in the United States, but current screening tests have low sensitivity, high cost, or require invasive procedures. My proposal will generate a non-invasive, low-cost diagnostic workflow to detect bladder cancer, consisting of a novel method to enrich the cells that give rise to bladder cancer from voided urine and a flow-cytometry assay to detect tumor-specific DNA changes in those cells with high performance characteristics. The goal of this work is to improve outcomes of patients with bladder cancer through the early detection of their disease, when it can be cured without removal of the bladder.

PI_NAMEs: DUDLEY, JONATHAN CARL (contact)

PROGRAM_OFFICER_NAME: BIAN, YANSONG

PROJECT_TERMS: Address;Aneuploidy;Award;Benign;Biological Assay;Biological Markers;Biometry;Biopsy;Biotechnology;Bladder Neoplasm;Blood;cancer biomarkers;cancer cell;Cancer Detection;Cancer Patient;Cancerous;Cell Size;cell type;Cells;Characteristics;Clinical;Clinical Trials;Clonal Expansion;Complex;cost;Cystectomy;Cytolysis;Data;deep sequencing;Detection;detection assay;Diagnostic;Diagnostic Procedure;diagnostic tool;Disease;DNA;Early Diagnosis;Flow Cytometry;Future;Gene Mutation;Goals;Graph;Hematopoiesis;Hematuria;Hospitals;improved;improved outcome;Laboratories;Leukocytes;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Medical Oncology;Mentorship;Methodology;Methods;Microscopy;Molecular;Mutation Detection;Nature;neoplastic cell;next generation sequencing;Noise;Non-Invasive Detection;novel;Pathology;Patient-Focused Outcomes;Patients;Performance;performance tests;Physicians;Population;Predisposition;Procedures;programs;Prospective Studies;Research;Research Design;Retrospective cohort study;Sampling;Scientist;screening;Screening for cancer;Sensitivity and Specificity;skills;Solid Neoplasm;specific biomarkers;Specificity;Specimen;Testing;Training;Transitional Cell Carcinoma;tumor DNA;Tumor Pathology;United States;urinary;Urine;Urology;Urothelial Cell;Urothelium;Work

PROJECT_TITLE: Early detection of bladder cancer through urothelial cell enrichment and DNA flow cytometry

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Bioengineering;Brain Disorders;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Dissemination and Implementation Research;Health Services;Lewy Body Dementia;Neurodegenerative;Neurosciences;Rehabilitation;Rural Health;Social Determinants of Health;Telehealth

ORG_CITY: GAINESVILLE

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Project Narrative Individuals with Lewy body dementia (LBD), one of the Alzheimer’s disease-related dementias, frequently have difficulty accessing specialty care due to limited access to medical specialists, rural residence, travel distances, and physical, cognitive, and behavioral impairments making travel to appointments more challenging. I propose to develop and test a stakeholder-designed telemedicine model of LBD interdisciplinary care. I will also assess the use of a Samsung Galaxy watch to measure a potentially modifiable risk factor of mortality called life-space mobility (the spatial area and frequency through which an individual moves through).

PI_NAMEs: PATEL, BHAVANA  (contact)

PROGRAM_OFFICER_NAME: LUO, YUAN

PROJECT_TERMS: Address;advocacy organizations;Affect;Alzheimer's disease related dementia;American;Appointment;Area;behavior change;behavioral impairment;care delivery;career;Caregiver Burden;Caregivers;Caring;Clinic;Clinical;Clinical Trials;Clinical Trials Design;Cognitive;Communication;Country;Data;Data Analyses;Dementia;dementia care;Dependence;design;Disease;dissemination science;Elements;experience;falls;Family;Florida;Frequencies;Future;Galaxy;Goals;Grant;Health;health management;Health Personnel;Home;Impaired cognition;implementation outcomes;implementation science;Improve Access;improved;Individual;Intervention;Interview;K-Series Research Career Programs;Lewy Body Dementia;Life;Life Style;Location;Measurement;Measures;medical specialist;medical specialties;Mentors;Mobility decline;Modeling;modifiable risk;mortality;Movement;Nature;Nerve Degeneration;Nervous System Disorder;neurodegenerative dementia;Nutritional;older adult;Outcome;Outcome Assessment;Outcome Measure;Parkinsonian Disorders;Patient Care;Patient Outcomes Assessments;Patient Self-Report;patient-level barriers;Patients;Persons;pharmacologic;Physical activity;physical impairment;pilot test;pilot trial;Population;Pragmatic clinical trial;Preparation;Professional Organizations;Qualitative Research;Quality of Care;Quality of life;Questionnaires;Randomized;Randomized Controlled Clinical Trials;Rehabilitation therapy;Reporting;Research;Research Methodology;Research Personnel;Resources;Risk Factors;Role;rural residence;satisfaction;Schedule;Science;secondary analysis;Services;skills;Social isolation;Social support;Social Workers;Specialist;Supervision;System;telehealth;Telemedicine;Testing;Training;Travel;treatment as usual;United States;Universities;usability;usual care arm;virtual;virtual delivery;virtual model;virtual platform;Visit;wearable device;wearable sensor technology

PROJECT_TITLE: Multi-Stakeholder Engagement for Interdisciplinary Telehealth in Lewy Body Dementia

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Behavior and Social Science of Aging Study Section[NIA-S]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurosciences;Physical Injury - Accidents and Adverse Effects;Social Determinants of Health;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: ALBUQUERQUE

ORG_NAME: LOVELACE BIOMEDICAL RESEARCH INSTITUTE

ORG_STATE: NM

PHR: Project Narrative Forensic populations have a rate of traumatic brain injury seven times higher than the general population. Traumatic brain injury is a risk factor for risk-taking behavior, substance use and future offending. There is almost no neuroimaging literature on brain injury in forensic populations. Here we leverage an existing sample and follow-up with a large subsample (n=300) of male and female offenders with varying history and severity of brain injury. This will create a longitudinal time-point to assess change-over-time in neuroimaging measures and relate these to brain injury and other risk factors. Algorithms developed in our laboratory will be tested to assess their generalizability to measuring brain injury and cognitive decline from multimodal neuroimaging data.

PI_NAMEs: KIEHL, KENT A (contact);KOENIGS, MICHAEL R.

PROGRAM_OFFICER_NAME: UMOH, NSINI ALEASE

PROJECT_TERMS: Acceleration;Address;African American;Age;aged;Algorithms;Behavior;behavior prediction;behavioral outcome;Brain;brain based;Brain Injuries;Chronology;Classification;classification algorithm;Clinical;Clinical assessments;Cognitive;Communities;comorbidity;Consent;Data;Data Set;data sharing;Databases;Dementia;Detection;Diagnosis;Diffusion;ethnic diversity;Ethnic Origin;Evaluation;Female;follow-up;Follow-Up Studies;Forensic Medicine;Functional disorder;Funding;Future;General Population;Health;high risk population;Hispanic;Image;Impaired cognition;Impairment;Imprisonment;improved;independent component analysis;Individual;Injury;Institution;Laboratories;Literature;longitudinal dataset;Longitudinal Studies;Magnetic Resonance Imaging;male;Measures;men;Mental Depression;mild cognitive impairment;mild traumatic brain injury;Minority Groups;Modeling;multimodal neuroimaging;National Institute of Neurological Disorders and Stroke;Native Americans;Neurocognitive;Neurocognitive Deficit;Neurodegenerative Disorders;neuroimaging;neuroimaging marker;Neuropsychology;offender;Outcome;Participant;Pathologic Processes;Pathology;pediatric trauma;Phenotype;Population;predictive modeling;Process;Protocols documentation;psychopathic personality;Public Health;Race;Recording of previous events;Reproducibility;Research;Research Personnel;Resources;Risk;Risk Factors;Risk Taking;Sampling;Secure;Severities;sex;social;Specific qualifier value;Substance abuse problem;substance use;Testing;Time;tool;Traumatic Brain Injury;Twin Multiple Birth;Underserved Population;United States National Institutes of Health;Woman;Work

PROJECT_TITLE: A longitudinal study of traumatic brain injury in a high-risk population

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


NIH_SPENDING_CATS: Cancer;Childhood Leukemia;Hematology;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

ORG_STATE: MA

PHR: Project Narrative The antileukemic drug asparaginase is a central component of curative therapy for several acute leukemias, but the development of resistance is a major clinical problem with a poor prognosis. We found that inhibition of the kinase GSK3α induces asparaginase sensitization in several drug-resistant subtypes of acute leukemia. We propose to investigate the biology underlying this potent therapeutic interaction, which is expected to provide fundamental insights into the amino acid starvation response, and allow its rational therapeutic exploitation for maximal clinical benefit.

PI_NAMEs: GUTIERREZ, ALEJANDRO  (contact)

PROGRAM_OFFICER_NAME: JHAPPAN, CHAMELLI

PROJECT_TERMS: Acute leukemia;Acute Lymphocytic Leukemia;Acute Myelocytic Leukemia;Address;Amino Acids;Anabolism;antileukemic agent;asparaginase;Asparagine;B-Cell Acute Lymphoblastic Leukemia;beta catenin;Biology;cancer therapy;Carcinoma;Cell Cycle Arrest;Cell Death;Clinical;Colon Carcinoma;curative treatments;Cytoplasmic Inclusion;Data;Disease;Drug resistance;Drug Sensitization;Enzymes;experimental study;Generations;Genetic Screening;genome-wide;glycogen synthase kinase 3 beta;Hematopoietic stem cells;high risk;Human;improved;in vivo;inhibitor;innovation;insight;interest;Knowledge;leukemia;leukemia relapse;Leukemic Cell;logarithm;Malignant Neoplasms;Mediating;Modeling;Molecular;Mus;Mutation;Myeloid Leukemia;N-terminal;Non-Essential Amino Acid;Normal Cell;Oncogenic;paralogous gene;Pathway interactions;patient derived xenograft model;Phase;Phenocopy;Phosphorylation;Phosphotransferases;Process;Prognosis;prospective;protein degradation;Protein Isoforms;Proteins;Refractory;Regulation;Resistance;Resistance development;resistance mechanism;response;Role;Signal Transduction;Signal Transduction Induction;Source;Starvation;synthetic lethal interaction;Testing;Therapeutic;Therapeutic Index;therapeutically effective;Toxic effect;Translating;treatment response;Ubiquitination;WNT Signaling Pathway

PROJECT_TITLE: Defining and targeting asparaginase resistance mechanisms in high-risk acute leukemias

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 1 Study Section[MCT1]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: PASADENA

ORG_NAME: CALIFORNIA INSTITUTE OF TECHNOLOGY

PHR: Project Narrative The proposed research is relevant to public health because it develops new methods to investigate the neural circuits governing naturalistic social behaviors in animal models, and such behaviors are often disrupted in human psychiatric disorders such as autism, schizophrenia, and depression. Our objective is to use computer vision and machine learning algorithms (AI) to produce detailed and reproducible measurements capturing the richness of social behaviors, and to correlate those behaviors with simultaneously recorded neural activity in freely interacting animals. We apply these techniques in established and novel social behavior assays to test hypotheses about the neural mechanisms underlying social behavioral decision-making.

PI_NAMEs: ANDERSON, DAVID J (contact);PERONA, PIETRO

PROGRAM_OFFICER_NAME: VAZIRI, SIAVASH

PROJECT_TERMS: Address;Adoption;Adult;Affect;Amygdaloid structure;Animal Behavior;Animal Model;Animals;Area;autism spectrum disorder;Behavior;Behavior Control;Behavioral;Behavioral Assay;Behavioral Model;behavioral study;Benchmarking;Biological Assay;body position;Brain;Brain region;Calcium;Cell Nucleus;Classification;collaborative approach;Collection;Communities;Complex;Computer software;Computer Vision Systems;computerized tools;Computing Methodologies;Control Animal;Data;Data Set;Decision Making;design;Development;Educational process of instructing;Endoscopy;Environment;experience;experimental study;flexibility;Future;generative models;Goals;Grain;Home;Hour;Human;Hypothalamic structure;Image;improved;innovation;insight;interest;Joints;Link;Machine Learning;machine learning algorithm;Manuals;mathematical model;Measurement;Measures;Mental Depression;Mental disorders;Methods;Modeling;Motivation;Movement;multimodality;Mus;Mutation;National Institute of Mental Health;neural;neural circuit;neural correlate;neuroimaging;neuromechanism;Neuronal Dysfunction;neuroregulation;Neurosciences;novel;Performance;Population Dynamics;Public Health;Reciprocal Social Interaction;Reproducibility;Research;Resolution;Resources;Role;Schizophrenia;social;Social Behavior;Social Controls;social defeat;Social Interaction;social structure;Structure;System;Techniques;temporal measurement;Testing;theories;Time;tool;Training;transfer learning;user-friendly;Variant;Work

PROJECT_TITLE: Multimodal, integrated analysis of neural activity and naturalistic social behavior in freely moving mice

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hematology;Pediatric;Prevention;Rare Diseases;Sickle Cell Disease;Social Determinants of Health

ORG_CITY: HOUSTON

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: RICE UNIVERSITY

ORG_STATE: TX

PHR: Project Narrative Sickle cell disease (SCD) is a devastating genetic blood disorder that disproportionately affects individuals living in low- and middle-income countries and is associated with significant morbidity and mortality, especially in children under age 5. Early diagnosis and treatment could save an estimated 9 million lives by 2050, but currently available tests are either too costly and complex, or ineffective at diagnosing SCD in children who have received emergency blood transfusions to treat acute, severe anemia resulting from SCD. A novel DNA-based nucleic acid amplification test for SCD diagnosis at the point of care could enable immediate and appropriate treatment, thus decreasing the number of deaths of young children due to SCD.

PI_NAMEs: RICHARDS-KORTUM, REBECCA R. (contact)

PROGRAM_OFFICER_NAME: GOLDBERG, ILANA GRACE

PROJECT_TERMS: 5 year old;Abnormal Hemoglobins;accurate diagnostics;Acute;acute care;Address;Affect;Africa;Africa South of the Sahara;Age;Alleles;Anemia;beta Globin;Biological Assay;Biomedical Engineering;Birth;Blood;Blood capillaries;Blood donor;Blood specimen;Blood Transfusion;Buffers;Cells;Cessation of life;Child;Child Care;Childhood;Clinical;clinical care;clinical diagnostics;Clinical Research;clinically relevant;Code;college;Complex;cost;Cytolysis;design;Detection;Devices;Diagnosis;Diagnostic;diagnostic platform;Diagnostic tests;diagnostic tool;Disease;disease diagnosis;disease diagnostic;Disease Management;DNA;DNA amplification;DNA analysis;Drops;Drug resistance;Early Diagnosis;Early treatment;Education;Electrophoresis;Emergency Situation;Equipment;Erythrocytes;experience;Fingers;Freeze Drying;Genes;Genetic;Genomic DNA;Genotype;global health;Globin;Goals;Hematological Disease;Hematology;Hemoglobin;Hemoglobin C Disease;hemoglobin polymer;High Pressure Liquid Chromatography;Hospitals;Human;Human Resources;improved;Individual;Infant;Infrastructure;Inherited;Isoelectric Focusing;isothermal amplification;Lateral;Life;low and middle-income countries;Malawi;Malignant Neoplasms;Medicine;meetings;Morbidity - disease rate;mortality;Mutation;neonate;Newborn Infant;novel;Nucleic Acid Amplification Tests;Nucleic Acids;Nucleotides;Optics;Pain;Pathologic;Patients;Performance;Persons;Pilot Projects;Point Mutation;point of care;Point of Care Technology;point of care testing;point-of-care diagnostics;Polymerase;Positioning Attribute;Preparation;prevent;Preventive treatment;Proteins;Provider;rapid detection;Reaction;Reagent;recombinase;Research;resistance mutation;Resource-limited setting;Rice;Sampling;screening;screening program;Sensitivity and Specificity;Sickle Cell;Sickle Cell Anemia;Sickle Cell Trait;Sickle Hemoglobin;Specificity;Testing;Texas;Time;Training;Transfusion;Translating;Translational Research;Tube;Universities;usability;user-friendly;Variant;Whole Blood

PROJECT_TITLE: A Sample-to-Answer Point-of-Care Diagnostic for Recently Transfused Sickle Cell Anemia Patients in Low Resource Settings

STUDY_SECTION: ISD

STUDY_SECTION_NAME: Instrumentation and Systems Development Study Section[ISD]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Physical Injury - Accidents and Adverse Effects;Prevention;Social Determinants of Health;Substance Misuse;Underage Drinking;Violence Against Women;Violence Research;Women's Health Research;Youth Violence;Youth Violence Prevention

ORG_CITY: ATLANTA

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: GEORGIA STATE UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Heavy episodic drinking and sexual assault (SA) are problematic on college campuses and risk differs based on gender identity and sexual orientation. Alcohol and Sexual Assault Prevention (ASAP) is a web-based personalized feedback intervention for alcohol use and SA tailored based on risk group (cisgender heterosexual men, cisgender heterosexual women, and sexual/gender minorities). The current study will assess the short- and long-term efficacy of ASAP on heavy episodic drinking and SA among college students.

PI_NAMEs: GILMORE, AMANDA KATHERINE (contact)

PROGRAM_OFFICER_NAME: FREEMAN, ROBERT

PROJECT_TERMS: Address;aged;Alcohol consumption;alcohol intervention;Alcohols;asexual;assault;attentional control;Behavior Therapy;binge drinking;cisgender;college;comparative efficacy;comparison control;comparison intervention;coping;cost;Data;drinking;Educational Intervention;efficacious intervention;efficacy evaluation;efficacy testing;Ensure;experience;feasibility trial;Feedback;follow-up;Funding;Gender;Gender Identity;gender minority group;genderqueer;Goals;Government;Grant;Guidelines;Health Care Costs;Heterosexuals;high risk;Incidence;innovation;Intersex;Intervention;Intoxication;Lesbian Gay Bisexual;Long-Term Effects;men;minority student;National Institute on Alcohol Abuse and Alcoholism;nonbinary;novel;Online Systems;Outcome;peer;personalized intervention;personalized normative feedback;post intervention;Prevention;prevention practice;Prevention program;programs;Public Health;public health priorities;queer;Randomized;Randomized, Controlled Trials;Recommendation;recruit;reduced alcohol use;Research;Resistance;Risk;Risk Reduction;Sampling;Self Efficacy;Sex Orientation;Sexual and Gender Minorities;sexual assault;sexual minority group;sexual minority stress;social norm;student drinking;student participation;Students;Subgroup;Testing;Universities;university student;usability;Victimization;web-based intervention;Woman;Work;young adult

PROJECT_TITLE: Personalized Integrated Alcohol and Sexual Assault Prevention among College Students

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


ADMINISTERING_IC: HG

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Biotechnology;Data Science;Genetics;Human Genome

ORG_CITY: Aurora

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Narrative A genomics diverse community of data scientists are needed to fully use the growing genetics and data to support biomedical research and translation into the clinic. Here, we present the Pathways in Genomic Data Science (PATH-GDS) research experience program where we will recruit, train, and build a community of genomic data scientists from groups traditionally underrepresented in biomedical research.

PI_NAMEs: FRENCH, JOSHUA P;HENDRICKS, AUDREY E (contact);LANGE, LESLIE A

PROGRAM_OFFICER_NAME: XIRASAGAR, SANDHYA

PROJECT_TERMS: Academia;Biomedical Research;career;Clinic;Collaborations;Colorado;Communication;Communities;community college;community engagement;Creativeness;Data;Data Science;Data Scientist;Data Security;Disease;Disparity;diverse data;doctoral student;Dryness;early awareness;Economics;Ensure;Ethics;Etiology;experience;faculty mentor;faculty support;First Generation College Students;Future;Genetic;genome sciences;genomic data;Genomics;Grant;Health;Hispanic;Home;Human;human genomics;Individual;Industry;innovation;Institution;laboratory experience;Mathematics;Medical;Medical Genetics;Mentors;metropolitan;outreach;Participant;Pathway interactions;peer coaching;Persons;Positioning Attribute;precision medicine;Professional Competence;programs;recruit;Research;Research Personnel;Research Training;Resources;Science;Series;Services;skills;statistics;Students;Training;Training Programs;Translations;undergraduate student;Underrepresented Populations;United States;United States National Institutes of Health;Universities;university student;Wages;Work

PROJECT_TITLE: Research experience pathways in genomic data science (PATH-GDS) for underrepresented groups


ORG_CITY: OKLAHOMA CITY

ORG_NAME: OKLAHOMA MEDICAL RESEARCH FOUNDATION

ORG_STATE: OK

PHR: NARRATIVE – PUBLIC HEALTH RELEVANCE STATEMENT Mitochondria are essential organelles in all eukaryotic cells, and their dysfunction has severe consequences in development and diseases. Mitochondria are highly dynamic through biogenesis, trafficking, changing morphology and targeted removal. Our research seeks fundamental understanding of the regulatory biology of mitochondria under normal physiology focusing on the crosstalk among mitochondrial dynamics, mitochondrial functions, cellular metabolism and signaling.

PI_NAMEs: ZHAO, MENG  (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TERMS: Bioenergetics;Biogenesis;Biology;Cell Differentiation process;Cell Lineage;Cell model;Cell Physiology;Cell Survival;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Cues;Defect;Development;Disease;Environment;Epigenetic Process;Eukaryotic Cell;Event;Excision;Functional disorder;Genetic;Genetic Transcription;high resolution imaging;Maintenance;Malignant Neoplasms;Mediating;Metabolic;Metabolism;Mitochondria;mitochondrial metabolism;Modification;Morphology;Organ Culture Techniques;Organelles;Pathogenesis;pharmacologic;Physiology;Process;public health relevance;Publishing;Regulation;Research;Role;Signal Transduction;Specific qualifier value;stem cells;System;Therapeutic;tool;trafficking;Work

PROJECT_TITLE: The role of mitochondrial regulation in cell lineage specification and function

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-M(55)R]


NIH_SPENDING_CATS: Cancer;Clinical Research;Colorectal Cancer;Digestive Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Metastatic disease accounts for >90% of cancer-related deaths worldwide, yet this phase of tumor progression is the least biologically understood. To address this challenge, we will integrate newly developed protein phenotyping technology, sophisticated computational biologic analyses, and an understudied neoplastic hybrid cell that represents the largest tumor population in peripheral blood. Our proposed study will explore the biology underlying the lifecycle of a disseminated neoplastic hybrid cells providing new insights into metastatic disease effectors, identification of pre-metastatic tumor states, and evaluation of a stage II colorectal cancer patient cohort in need of new approaches for treatment stratification to impact their survival.

PI_NAMEs: GIBBS, SUMMER LYNNE;WONG, MELISSA H. (contact)

PROGRAM_OFFICER_NAME: WATSON, JOANNA M

PROJECT_TERMS: Address;Aggressive behavior;Architecture;Area;Behavioral;Binding Sites;Biological;Biological Assay;Biology;Blood specimen;cancer care;Cancer Etiology;Cells;Cellular biology;Cessation of life;Circulation;Clinical;cohort;colon cancer patients;Colorectal Cancer;Computer Analysis;Copy Number Polymorphism;Development;Diagnosis;Disease;Disseminated Malignant Neoplasm;Distant;DNA Sequence Alteration;Effector Cell;Elements;Evaluation;Evolution;fluorescence imaging;Foundations;Gene Expression;Human;Hybrid Cells;Hybrids;Immunofluorescence Immunologic;in vivo;Incidence;innovation;insight;Investigation;Knowledge;Life Cycle Stages;Link;Location;longitudinal analysis;Malignant Neoplasms;Mediating;metastatic process;Micrometastasis;migration;Molecular;multidisciplinary;multiple omics;Nature;Neoplasm Circulating Cells;Neoplasm Metastasis;neoplastic;neoplastic cell;novel;novel therapeutic intervention;Outcome;Patient Care;Patients;Periodicity;peripheral blood;Phase;Phenotype;Population;Primary Neoplasm;Property;Prospective Studies;protein expression;Proteins;Publishing;Recurrence;Recurrent tumor;Reporting;Risk;Role;Sampling;Site;Spatial Distribution;stem cells;stemness;Technology;technology development;Testing;Therapeutic;Time;treatment response;treatment stratification;tumor;Tumor Biology;tumor growth;tumor initiation;tumor progression;Tumor stage;Work;Zebrafish

PROJECT_TITLE: Mechanistic understanding of the lifecycle of a circulating hybrid cell

STUDY_SECTION: TPM

STUDY_SECTION_NAME: Tumor Progression and Metastasis Study Section[TPM]


NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Data Science;Health Services;Heart Disease;Hypertension;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

ORG_STATE: PA

PHR: The objective of the major study proposed in this K01 application is to first, develop and validate a random forest machine learning algorithm (MLA) to predict risk of uncontrolled blood pressure among adults with hypertension. Second, identify barriers and facilitators to implementing an MLA-clinical decision support (CDS) tool that predicts uncontrolled blood pressure into clinical settings by conducting key-informant interviews and focus groups with primary care clinicians and patients. Third, compare clinical management of hypertension with and without information from the MLA on whether a patient will have uncontrolled blood pressure through a case-vignette study.

PI_NAMEs: TAJEU, GABRIEL S (contact)

PROGRAM_OFFICER_NAME: REDMOND, NICOLE

PROJECT_TERMS: Address;Adult;algorithm development;Algorithms;Anti-Hypertensive Agents;Attitude;Award;Bass;Blood Pressure;blood pressure control;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;career;Caring;Chronic Disease;Clinic Visits;Clinical;clinical care;clinical decision support;Clinical Management;clinical practice;Clinical Research;Clinical Treatment;Complex;Computerized Medical Record;Data;Death Rate;design;Diabetic Retinopathy;diet and exercise;dosage;Education;effective therapy;Event;experience;Failure;Focus Groups;Future;Goals;Guidelines;Health;Health Services;Health system;Heart failure;high risk;high risk population;Hospital Mortality;Hypertension;hypertension control;hypertension treatment;improved;informant;Intervention;Interview;Knowledge;Leadership;Length of Stay;Life Style Modification;Logistic Regressions;Machine Learning;machine learning algorithm;machine learning prediction algorithm;Measurement;medication compliance;Medicine;Mentors;mid-career faculty;Modeling;Monitor;mortality;Obesity;outcome prediction;Patients;Pattern Recognition;Persons;Pharmaceutical Preparations;Philadelphia;Physicians;pilot test;Population;Population Intervention;Populations at Risk;predictive modeling;predictive tools;primary care clinician;Principal Investigator;prototype;Provider;Public Health;Qualitative Research;random forest;Randomized;Recommendation;Regimen;Reporting;Research;Research Personnel;Research Technics;Resources;risk prediction;skills;socioeconomics;Statistical Methods;support tools;Testing;tool;tool development;Training;Uncertainty;underserved area;United States;Universities;Validation;Visit;Zoran

PROJECT_TITLE: Machine Learning to Reduce Hypertension Treatment Clinical Inertia

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(JA)]


ADMINISTERING_IC: MD

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Violence Against Women;Violence Research;Women's Health Research

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Intimate partner violence (IPV) is considered a public health problem in the United States, with many scholars identifying it as a public health crisis. American Indian (AI) and Black women in the United States are disproportionately affected by IPV with the communities in which they live also currently disproportionately affected by the COVID-19 pandemic. It is an urgent matter of public health that we systematically identify, in an effort to minimize, the barriers to help- seeking for IPV that AI and Black women are experiencing during the pandemic, in order to inform policy and improve health outcomes for AI and Black populations of women.

PI_NAMEs: MKANDAWIRE-VALHMU, LUCY  (contact)

PROGRAM_OFFICER_NAME: MUJURU, PRISCAH

PROJECT_TERMS: Address;Advocate;Affect;American Indian Women;American Indians;Area;Black Populations;Black race;black women;Cessation of life;Characteristics;Cities;Clinic;Communities;community advisory board;community based participatory approach;community based participatory research;community partners;Complex;coping;County;COVID-19;COVID-19 pandemic;COVID-19 pandemic effects;Data;Disasters;Economics;Emergency Health Services;Employment;Employment Opportunities;Ensure;experience;Face;Family;Focus Groups;Gender;Generations;Geography;Goals;Group Interviews;Health;health care service;Health Policy;health practice;Health Services Accessibility;help-seeking behavior;high risk;Home;Homicide;Imprisonment;improved;Indigenous;Individual;Inequality;Institution;Interview;intimate partner violence;Knowledge;Law Enforcement;Literature;Measures;member;Methods;metropolitan;Mission;National Institute on Minority Health and Health Disparities;Nature;Outcome;pandemic disease;pandemic impact;Participant;Pattern;peace;Pilot Projects;Policies;poor health outcome;Population;Poverty;Public Health;Quarantine;Race;Racial Segregation;racism;Recommendation;recruit;research study;resilience;Resources;response;Risk;Rural;rural area;Sampling;Scholarship;segregation;Services;Site;social;Social Distance;Social Network;Social support;Social Work;stressor;structural determinants;Structural Racism;Structure;Surveys;System;Time;United States;Universities;urban area;urban Native American;urban residence;Violence;Voice;Wisconsin;Woman;Work

PROJECT_TITLE: Impact of the COVID-19 Pandemic on Help Seeking of American Indian and Black Women Experiencing Intimate Partner Violence

STUDY_SECTION: CIHB

STUDY_SECTION_NAME: Community Influences on Health Behavior Study Section[CIHB]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: DUARTE

ORG_NAME: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE

ORG_STATE: CA

PHR: Project Narrative: This application will evaluate our hypothesis that circulating extracellular vesicles (EVs) in T1D, through distinct molecular characteristics, are cytotoxic to beta cell health, thus contributing to the pathogenesis of T1D; with the potential to serve as biomarkers for early disease diagnosis. Our goal is to decode the molecular messages that circulating EVs carry and decipher their functional characteristics. These studies have the potential to provide novel insights into disease pathology as well as to identify new biomarkers and therapeutics for T1D.

PI_NAMEs: SAHOO, SUSMITA ;VASAVADA, RUPANGI C (contact)

PROGRAM_OFFICER_NAME: BLONDEL, OLIVIER

PROJECT_TERMS: Address;Age;Alpha Cell;Autoantibodies;Autoantigens;Autoimmune Diseases;Autoimmunity;Beta Cell;biomarker identification;Cell Death;Cell Physiology;Cessation of life;Characteristics;Childhood;clinical biomarkers;clinically relevant;Code;Communication;cytotoxic;cytotoxicity;Data;diabetes control;Diabetes Mellitus;diabetic;Diagnosis;differential expression;Disease;disease diagnosis;Disease Progression;early detection biomarkers;Ethnic Origin;Event;extracellular vesicles;Female;Functional disorder;functional loss;Glucagon;Goals;Health;Human;Hyperglycemia;in vivo;Inbred NOD Mice;insight;insulin dependent diabetes mellitus onset;insulin secretion;Insulin-Dependent Diabetes Mellitus;islet;Knowledge;Mediating;Mediator;MicroRNAs;Mitochondria;Modeling;Molecular;Mus;Non obese;non-diabetic;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutics;Pathogenesis;Pathology;Patients;Plasma;Play;Research;Resistance;RNA;Rodent Model;Role;Severe Combined Immunodeficiency;sex;signature molecule;Testing;Therapeutic;Untranslated RNA;uptake

PROJECT_TITLE: Circulating Extracellular Vesicles in the Pathogenesis of Type 1 Diabetes

STUDY_SECTION: CSME

STUDY_SECTION_NAME: Cell Signaling and Molecular Endocrinology Study Section[CSME]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Dissemination and Implementation Research;HIV/AIDS;Health Services;Infectious Diseases;Pediatric;Prevention

PHR: Project narrative Adolescents and young adults living with HIV need tailored interventions that address their unique social, interpersonal, and developmental needs. Leveraging data from a parent cluster randomized controlled trial that will be testing a Stepped Care intervention to improve retention in care among adolescents and young adults living with HIV, this F31 project aims to evaluate implementation outcomes of the intervention as it is delivered across 10 Kenyan healthcare facilities. This project will provide the F31 candidate with the opportunity to acquire new methods and content-area expertise and develop necessary skills to become an independent researcher.

PI_NAMEs: CHHUN, NOK  (contact)

PROGRAM_OFFICER_NAME: YATES, FRANKLIN WILLEM

PROJECT_TERMS: Address;Adolescent;Adolescent and Young Adult;Adoption;Adult;Africa South of the Sahara;Caring;Categories;Characteristics;Client;clinical predictors;community based care;Consolidated Framework for Implementation Research;Data;design;Development;doctoral student;effectiveness evaluation;Effectiveness of Interventions;Eligibility Determination;Ensure;Evaluation;evidence base;Evidence based intervention;Failure;Feedback;Focus Groups;follow-up;Frequencies;Friends;Future;Goals;Health care facility;health care settings;health empowerment;Health Personnel;Health Services;Health system;Healthcare Systems;high-risk adolescents;HIV;HIV Infections;HIV-infected adolescents;implementation determinants;implementation evaluation;implementation facilitators;implementation intervention;implementation outcomes;implementation science;implementation strategy;improved;Individual;Intervention;Interview;Kenya;Measures;meetings;Methodology;Methods;Modeling;Modification;mortality;Nature;Outcome;Parents;Penetration;Perception;Persons;Phase;post intervention;pre-doctoral;predictive tools;preference;Procedures;Process;Qualitative Methods;Randomized, Controlled Trials;Readiness;Recommendation;Reporting;Research;Research Personnel;Resource-limited setting;Resources;Risk;risk prediction;routine practice;scale up;service delivery;Service delivery model;Services;skills;social;success;Surveys;Testing;Time;Time Series Analysis;Training;treatment adherence;Treatment outcome;trend;Variant;Viral;Youth

PROJECT_TITLE: Improving Retention in Care for Adolescents and Young Adults in Kenya: Implementation Science to Support Adaptation and Integration of a Stepped Care Intervention


ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Children are not small adults; yet clinicians treating pediatric patients rely heavily on information collected in randomized and non-randomized studies of adult populations. To address this evidence gap – which puts pediatric patients at increased risk – we propose to develop and test the performance of tree-based scan statistic (TreeScan) approaches for the systematic and simultaneous evaluation of multiple potential adverse outcomes in pediatric populations, and to implement these methods for prospective sequential surveillance of new pediatric medications. This project will provide a critically needed tool that could lead to early detection of unsuspected adverse effects of drugs in pediatric populations if they exist and provide reassurance if no such safety concerns are detected.

PI_NAMEs: HUYBRECHTS, KRISTA F;WANG, SHIRLEY  (contact)

PROGRAM_OFFICER_NAME: REN, ZHAOXIA

PROJECT_TERMS: Acceleration;Address;Adult;Adverse drug effect;Adverse effects;Adverse event;adverse outcome;age related changes;Characteristics;Child;Childhood;Clinical;Clinical Research;Clinical Treatment;cohort;Complement;Complex;Data;Databases;Development;Drug Targeting;Drug usage;Early Diagnosis;Effectiveness;Electronic Health Record;epidemiology study;Ethics;Evaluation;Grant;Healthcare;Heterogeneity;innovation;Joints;Label;Left;Link;medication safety;Methodology;Methods;Monitor;novel therapeutics;off-label use;Outcome;Pattern;pediatric patients;Pediatrics;Performance;performance tests;Pharmaceutical Preparations;Pharmacoepidemiology;Population;Predisposition;prospective;Public Health;Randomized;Research;Research Personnel;Risk;Safety;safety assessment;Scanning;screening;Signal Transduction;simulation;Statistical Methods;statistics;System;Testing;Time;tool;treatment effect;treatment strategy;Trees;Uncertainty;Update;Vertebral column

PROJECT_TITLE: TreeScan to Evaluate the Safety of New Drugs in Pediatric Populations


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Cancer;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Depression;Health Services;Mental Health;Mental Illness;Palliative Care;Rehabilitation

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: PROJECT NARRATIVE The increasingly crucial role played by informal cancer caregivers (ICs) is often complicated by persistent anxiety and depression, but to date, current psychosocial interventions fail to adequately address IC anxiety and depression. This project is relevant to NIH’s mission as it represents a step in the development of an intervention – Emotion Regulation Therapy for Cancer Caregivers (ERT-C) – that has shown encouraging results in ameliorating IC anxiety and depression. If successful, ERT-C holds significant promise to not only improve the quality of life for ICs across the caregiving trajectory, but also yield downstream benefits to the patients for whom they provide care.

PI_NAMEs: APPLEBAUM, ALLISON ;MENNIN, DOUGLAS ;NELSON, CHRISTIAN J (contact)

PROGRAM_OFFICER_NAME: FERRER, REBECCA

PROJECT_TERMS: Address;Aftercare;Alcohol consumption;Anxiety;anxiety symptoms;Attention;behavior prediction;Behavioral;Biological;Blood Pressure;Cancer Patient;cancer therapy;Cardiovascular Diseases;care coordination;Caregivers;caregiving;Caring;Chronic;Chronic stress;clinical anxiety;clinical efficacy;Cognitive Therapy;comparative;coping;cost;cytokine;depressive symptoms;Disease;Distress;efficacy evaluation;emotion regulation;Emotional;Endocrine;Enrollment;experience;flexibility;follow-up;Friends;General Population;Health;Health behavior;Health Care Costs;health care service utilization;Healthcare Systems;Heart Rate;Hydrocortisone;Hyperphagia;improved;indexing;Individual;Inflammation;Inflammatory;informal caregiver;Interleukin-6;Intervention;Intervention Studies;Link;Major Depressive Disorder;Malignant Neoplasms;Mediating;Mediation;Medical;Medical Care Team;member;Mental Depression;Mind;mindfulness meditation;Mission;multi-site trial;Outcome;Patient Care;Patient Care Team;Patient-Focused Outcomes;Patients;perceived stress;Persons;Play;primary outcome;Process;Production;psychosocial;Quality of life;Randomized;Randomized, Controlled Trials;Regulation;Reporting;Resolution;Risk;Role;rumination;Salivary;Science;secondary outcome;Series;Shoulder;Site;skills;skills training;Sleeplessness;social;Stress;sustained attention;systemic inflammatory response;Therapeutic Intervention;therapy development;Thinking;Time;TNFRSF1A gene;Tobacco use;Uncompensated Care;United States;United States National Institutes of Health;Vertebral column;Waiting Lists;Work

PROJECT_TITLE: A Randomized Controlled Trial of Emotion Regulation Therapy for Cancer Caregivers: A Mechanism-Targeted Approach to Addressing Caregiver Distress

STUDY_SECTION: SPIP

STUDY_SECTION_NAME: Social Psychology, Personality and Interpersonal Processes Study Section[SPIP]


NIH_SPENDING_CATS: Clinical Research;Infectious Diseases;Malaria;Microbiome;Pediatric;Rare Diseases;Vector-Borne Diseases

ORG_CITY: INDIANAPOLIS

ORG_DEPT: PEDIATRICS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: PROJECT NARRATIVE Recent studies have shown that the trillions of microbes living on and within us profoundly influence multiple aspects of human physiology. Malaria remains a significant infectious disease causing the death of over 400,000 people annually. Completing these translational studies will lead to an improved understanding of the role of gut microbiota in differential severity of malaria in humans, which could lead to new strategies to prevent malaria-associated mortality.

PI_NAMEs: JOHN, CHANDY C.;SCHMIDT, NATHAN  (contact)

PROGRAM_OFFICER_NAME: RAO, MALLA R

PROJECT_TERMS: 16S ribosomal RNA sequencing;Acceleration;Affect;Africa South of the Sahara;African;Antibodies;B-Lymphocytes;Bacteria;bacterial community;Biological Models;Cause of Death;Cell Communication;Cell Count;Cerebral Malaria;Cessation of life;Characteristics;Child;Clinical;cohort;Communicable Diseases;Communities;Data;Development;Disease;Evolution;Exhibits;Feces;Fever;follow-up;Future;Germ-Free;gut bacteria;gut microbiome;gut microbiota;Health;Human;human data;Humoral Immunities;Immunity;Immunoglobulin Class Switching;improved;Infection;Knowledge;Malaria;malarial anemia;Malawi;Mali;Mediating;Microbe;microbiome;mortality;mouse model;Mus;novel;Output;Parasitemia;Parasites;Parasitic infection;Persons;Physiology;Plasmodium;Plasmodium falciparum;Plasmodium yoelii;Predisposition;prevent;prospective;Publishing;Reaction;response;Risk;Risk Factors;Rodent;Role;Severities;stool sample;Structure of germinal center of lymph node;Taxonomy;Testing;transcriptome sequencing;translational study;Uganda

PROJECT_TITLE: Gut microbiota and human malaria

STUDY_SECTION: CRFS

STUDY_SECTION_NAME: Clinical Research and Field Studies of Infectious Diseases Study Section[CRFS]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Disability Research;Health Services;Physical Rehabilitation;Prevention;Rehabilitation;Social Determinants of Health

ORG_DEPT: ADMINISTRATION

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: PROJECT NARRATIVE Losses in key functional abilities with age prevent many Americans from working in jobs of their choosing and hence healthy aging. The goal of this project is to adapt international methods for measuring functional ability to work to the U.S. context and use this information to identify targets for interventions that would restore or prevent loss of specific functional abilities among Americans.

PI_NAMEs: MAESTAS, NICOLE A (contact);MULLEN, KATHLEEN

PROGRAM_OFFICER_NAME: JAIN, KRITI MUNJAL

PROJECT_TERMS: Activities of Daily Living;Affect;Age;age group;American;Assessment tool;base;climate change;Cognitive;cost;Country;Data;data resource;Deterioration;Development;Disability Evaluation;Economic Factors;Economics;Education;effective intervention;Employment;Exercise;functional loss;Future;Goals;Health;healthy aging;human old age (65+);improved;Individual;instrument;International;Intervention;Knowledge;Life Cycle Stages;life span;Maps;Measures;Methods;Netherlands;Occupational;Occupations;pandemic potential;Personal Satisfaction;Persons;Population;prevent;Prevention;Procedures;Productivity;productivity loss;psychosocial;psychosocial wellbeing;public health intervention;Recovery;Rehabilitation therapy;Research;Respondent;response;Sampling;Scientific Advances and Accomplishments;Security;simulation;social;social factors;Standardization;standardize measure;Technology;Time;Vocational rehabilitation;Work

PROJECT_TITLE: Identifying Targets for Interventions to Improve Functional Ability to Work over the Life Course

STUDY_SECTION: SSPB

STUDY_SECTION_NAME: Social Sciences and Population Studies B Study Section[SSPB]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Cocaine;Genetics;Human Genome;Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: SAN JUAN

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF PUERTO RICO MED SCIENCES

ORG_STATE: PR

PHR: Narrative This project will test if the alteration of HCN channel function to progressive cocaine exposure is a critical element of drug action on the VTA resulting from epigenetic regulation acquired during the learning process using contingent and non-contingent animal models. One possible outcome of these studies is to identify risk factors for substance abuse disorders related to epigenetic regulation of an ionic channel that regulates neuronal biophysical properties. Knowledge of the epigenetic control of cocaine-induced biophysical neuronal changes ultimately will lead to the identification of new targets in the development of treatments for substance abuse disorders.

PI_NAMEs: JIMENEZ-RIVERA, CARLOS A (contact)

PROGRAM_OFFICER_NAME: REVILLEZA, MARIA

PROJECT_TERMS: addiction;Affect;Animal Model;Antibodies;Area;Behavioral;behavioral sensitization;Biological Assay;Biology;biophysical properties;Biophysics;Brain;Cations;Cells;chromatin remodeling;Chronic;Closure by clamp;Cocaine;cocaine exposure;cocaine sensitization;Consumption;Development;Disease;DNA Sequence;Dopamine;Dopaminergic Cell;dopaminergic neuron;drug action;Drug Exposure;drug of abuse;Electrophysiology (science);Elements;Epigenetic Process;epigenetic regulation;epigenomics;experimental study;Exposure to;Gene Expression;genome-wide;Genomics;HDAC2 gene;Histone Acetylation;Histone Deacetylase Inhibitor;Histone Deacetylation;histone modification;Hour;Human;In Vitro;in vivo;Incubated;information processing;Injections;Intervention;Ion Channel;Knowledge;Learning;Measurement;Measures;Modeling;Modification;Motor Activity;Natural Substance;neuroadaptation;Neurons;Neurotransmitters;next generation sequencing;Outcome Study;Participant;Pathway interactions;Pharmaceutical Preparations;pharmacologic;Physiological;prevent;Process;promoter;Property;Psychological reinforcement;Rattus;Regulation;response;Rewards;Risk Factors;Role;Self Administration;Slice;small hairpin RNA;Substance abuse problem;substance abuse treatment;Surface;Techniques;Testing;Therapeutic;therapy development;tool;Ventral Tegmental Area;voltage;voltage gated channel

PROJECT_TITLE: Elucidating Ih Biophysical Epigenetic Modifications in VTA Dopaminergic Neurons after Contingent and Non-Contingent Cocaine Administration


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Estrogen;Genetics;Human Genome;Precision Medicine;Prevention;Women's Health Research

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Sex differences in the incidence, age of onset, progression, and response to treatment in cancer are well documented. This project aims to understand how genetics contributes to observed cancer differences between men and women across a wide spectrum of cancers, with the goal of generating knowledge that can have a clinical impact. The project will: 1) Characterize sex differences at the molecular level in tumors derived from male and female patients, 2) Characterize sex differences in the contribution of inherited genetics to cancer risk, and 3) Discover mechanisms contributing to sex differences in response to cancer therapy.

PI_NAMEs: HUANG, RONG STEPHANIE ;STRANGER, BARBARA E (contact)

PROGRAM_OFFICER_NAME: LI, JERRY

PROJECT_TERMS: Affect;Age of Onset;Alleles;Allelic Imbalance;autosome;Awareness;Biological Models;Cancer Biology;Cancer cell line;cancer genome;cancer genomics;cancer risk;cancer therapy;Caring;Cell model;Characteristics;Clinical;Complex;computational pipelines;Data;dimorphism;Disease;Disparity;DNA Methylation;Drug Modelings;drug sensitivity;Environmental Exposure;Epigenetic Process;Exhibits;Exons;Expenditure;experience;Female;Gene Expression;Genes;Genetic;genetic architecture;Genetic Models;Genetic Risk;genetic risk factor;genetic variant;Genetic Variation;genome wide association study;Genomics;Germ Lines;Goals;Hepatocyte;Heritability;Hormonal;Hormones;Human;improved outcome;in vitro Model;Incidence;Individual;Inherited;Knowledge;Literature;lymphoblastoid cell line;male;Malignant Neoplasms;Mediating;men;Messenger RNA;MicroRNAs;Molecular;Morbidity - disease rate;mortality;Newly Diagnosed;novel marker;Oncogenes;Pathway interactions;Penetrance;Pharmaceutical Preparations;Pharmacogenomics;Pharmacotherapy;Phenotype;precision medicine;Precision Medicine Initiative;predictive modeling;Predisposition;Prognosis;protective factors;Protocols documentation;Regulation;Research;Resources;response;Risk;Risk Factors;Sampling;sex;Sex Chromosomes;Sex Differences;sexual dimorphism;Somatic Mutation;System;targeted treatment;Testing;The Cancer Genome Atlas;Therapeutic;therapeutic target;trait;transcriptome;treatment response;tumor;Tumor-Derived;United States;Variant;Woman;women patients;Work;Y Chromosome

PROJECT_TITLE: Genetic mechanisms underlying sexual dimorphism in cancer and response to therapy

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


NIH_SPENDING_CATS: Brain Disorders;Drug Abuse (NIDA only);Genetics;HIV/AIDS;Infectious Diseases;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Substance Misuse

ORG_NAME: BOSTON MEDICAL CENTER

PHR: NARRATIVE Microglia are long-lived central nervous system immune cells that have critical roles in brain immunity and neuron integrity. HIV-1 infection of microglia and the resulting activation of these cells is hypothesized to drive inflammation in the brain and AIDS-associated neurocognitive diseases. We are proposing to use a novel cell model to explore how HIV RNA expression in microglia mediates this inflammatory response. These studies are relevant for understanding how HIV perpetuates disease even in the presence of antiretroviral treatments and could provide new targets and strategies for treatments to improve the lives of people living with HIV.

PI_NAMEs: GUMMULURU, SURYARAM ;HENDERSON, ANDREW J (contact)

PROGRAM_OFFICER_NAME: TSAI, SHANG-YI ANNE

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Aging;antiretroviral therapy;Attenuated;Automobile Driving;Blood - brain barrier anatomy;Blood Vessels;Brain;Cell model;Cells;Central Nervous System;Chronic;chronic infection;Clonal Expansion;Coculture Techniques;comorbidity;cytokine;Data;Deterioration;Disease;Functional disorder;Genetic Transcription;HIV;HIV Infections;HIV-1;HIV-associated neurocognitive disorder;Human;Immune;Immune system;Immunity;Immunologic Surveillance;immunoregulation;Impaired cognition;improved;In Vitro;induced pluripotent stem cell;Infection;Inflammasome;Inflammation;Inflammatory;inflammatory milieu;Inflammatory Response;insight;Introns;Length;Literature;Macrophage;Maintenance;Mediating;Mediator;Microglia;Modeling;Mutation;Nerve Degeneration;Nervous System Trauma;Neurocognitive;Neurodegenerative Disorders;neuroinflammation;Neuronal Injury;Neurons;Neuropathogenesis;neuropsychiatry;novel;pathogen;Patients;permissiveness;Persons;Phagocytosis;Phosphorylation;Play;Pluripotent Stem Cells;Production;protein aggregation;Proviruses;Publishing;Repression;Reverse Transcription;RNA;Role;Shapes;Synapses;System;T-Lymphocyte;Testing;Transcript;treatment strategy;Viral;viral DNA;Viral Proteins;viral RNA;Virus;Virus Replication;Work

PROJECT_TITLE: Persistent HIV-1 expression and microglia dysfunction


NIH_SPENDING_CATS: Aging;Atherosclerosis;Cardiovascular;Clinical Research;Heart Disease;Heart Disease - Coronary Heart Disease;Infectious Diseases;Tickborne Diseases;Vector-Borne Diseases

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: NARRATIVE Humans with IgE sensitization to the mammalian oligosaccharide allergen galactose-a-1,3- galactose (a-gal) have larger coronary artery plaques and unstable plaque features signifying increased coronary artery disease (CAD) compared to those without IgE to a-gal. However, the causal role of IgE to a-gal in CAD is unknown. The proposed research seeks to understand whether IgE to a-gal directly promotes atherosclerotic plaque development and define immune mechanisms mediating IgE sensitization to a-gal linked to atherosclerotic cardiovascular disease in mice and humans.

PI_NAMEs: ERICKSON, LOREN D (contact);MCNAMARA, COLEEN A

PROGRAM_OFFICER_NAME: SUBRAMANIAN, HARIHARAN

PROJECT_TERMS: Address;Allergens;allergic response;alpha-gal syndrome;Ambylomma americanum;Anaphylaxis;Antibody Formation;Antibody Response;Antigens;Arterial Fatty Streak;Atherosclerosis;Attenuated;Automobile Driving;B-Lymphocytes;Bite;Blood Vessels;CCR6 gene;Cells;cohort;comparison control;Consumption;Coronary Angiography;Coronary Arteriosclerosis;Coronary artery;Dairying;Data;Development;Diet;Enzymes;Etiology;Exposure to;Food;Fostering;Frequencies;gain of function;Galactose;galactosyl-(1-3)galactose;Galactosyltransferases;High Prevalence;Histology;Human;humanized mouse;hypercholesterolemia;Hypersensitivity;IgE;Immediate hypersensitivity;Immune;Immunoglobulin Class Switching;Immunoglobulin Switch Recombination;Individual;Inflammation;Ingestion;Interleukin 4 Receptor;Interleukin-4;Link;Lipids;loss of function;Mammals;Measures;Meat;Mediating;Memory B-Lymphocyte;Modeling;Molecular;mouse model;multiple omics;Multivariate Analysis;Mus;Necrosis;novel;Oligosaccharides;Peripheral Blood Mononuclear Cell;Phenotype;Play;Population;Pre-Clinical Model;Production;Reaction;Regulation;Research;response;Risk;Role;Serum;Severity of illness;single cell analysis;STAT6 gene;Structure of germinal center of lymph node;Symptoms;Testing;Ticks;transcriptomics;ultrasound;vascular inflammation;virtual;Wild Type Mouse;Work

PROJECT_TITLE: IgE antibody responses to the oligosaccharide galactose-alpha-1,3-galactose (alpha-gal) in murine and human atherosclerosis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-VH-D(02)M]