NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cardiovascular;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Heart Disease;Nutrition;Obesity;Pediatric;Prevention;Primary Health Care;Social Determinants of Health

ORG_CITY: COLUMBUS

ORG_NAME: RESEARCH INST NATIONWIDE CHILDREN'S HOSP

PHR: PROJECT NARRATIVE: Black and low-income populations are disproportionately affected by obesity and its comorbidities, including cardiovascular disease. Although primary care health care providers could play an important role in providing tangible and practical lifestyle advice to prevent childhood obesity, they lack efficient and effective tools to engage parents and evoke change. This study will develop, assess, and evaluate the acceptability, feasibility, and preliminary efficacy of two visual communication tools that incorporate culturally relevant brief behavior change counseling grounded in motivational interviewing, to facilitate engagement in behavioral lifestyle counseling between primary care health care providers and Black parents from low-income households who are affected by obesity.

PI_NAMEs: KHALSA, AMRIK SINGH (contact)

PROGRAM_OFFICER_NAME: CAMPO, REBECCA A

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;Adopted;Adult;Affect;Area;Atherosclerosis;Awareness;Behavior;behavior change;Behavior Therapy;Behavioral;biobehavior;Black race;Cardiovascular Diseases;cardiovascular disorder prevention;cardiovascular disorder risk;cardiovascular health;career;career development;Characteristics;Child;Child Health;Clinical;clinical application;clinical encounter;Communication;Communication Tools;Communities;comorbidity;Competence;Counseling;Coupled;Data;design;Development;Development Plans;dietary;disorder risk;Disparity;disparity reduction;empowerment;Evaluation;Face;Family;Family member;Focus Groups;Future;Goals;Health;Health Personnel;high risk;Household;Image;improved;Income;Intention;interest;intergenerational;Intervention;Knowledge;Language;Learning Skill;Life;Life Style;Low income;Low Income Population;lower income families;Maintenance;Measurable;Medial;Mentorship;Motivation;motivational enhancement therapy;Names;Obesity;obesity in children;obesity risk;Outcome;Parents;Performance;Play;Population;post intervention;practice setting;prevent;Prevention;primary care setting;Primary Health Care;racial minority population;randomized controlled design;Randomized, Controlled Trials;Reporting;Research;Research Personnel;Risk;Risk Factors;Role;School-Age Population;Shapes;skill acquisition;socioeconomics;Standardization;Structure;Testing;Thick;tool;Ultrasonography;vision development;Visual;Visualization

PROJECT_TITLE: The Development and Evaluation of Visual Communication Tools to Convey Parental and Intergenerational Cardiovascular Disease Risk and Evoke Lifestyle Behavior Change in Low-income Black Families

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(JA)]


ADMINISTERING_IC: DC

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences;Nutrition

ORG_CITY: STONY BROOK

ORG_COUNTRY: UNITED STATES

ORG_DEPT: NEUROSCIENCES

ORG_FIPS: US

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

ORG_STATE: NY

PHR: PROJECT NARRATIVE  Taste and appetite are inherently intertwined, yet very little in known about the cortical circuits that integrate gustatory perception and expectation with interoception related to hunger/satiety. The gustatory cortex has been extensively studied for its involvement in taste perception and expectation, and for its role in mediating taste- related behaviors, decisions and learning. Recent data show that cortical responses to taste, anticipatory cues and spontaneous activity are affected by hunger and thirst. Yet, the nature and the function of these interoceptive homeostatic signals in the cortex is poorly understood. Here we propose to address this gap, focusing on a population of gustatory cortical neurons expressing gastrin-releasing peptide (GRP), a feeding-suppressing peptide. Neurons containing GRP are ideal candidates to integrate gustatory perception, expectation and interoception, and drive behavior through release of GRP.  We will combine anatomical and electrophysiological analyses, cellular imaging and manipulations of neural activity to unveil the organization and function of GRP in the circuit involving the gustatory cortex and the basolateral amygdala. The results of this research will advance our understanding of the neural basis of taste- based consumption and help us revise existing models of the function of the gustatory cortex. In addition to furthering our knowledge, this work will test the validity of GRP as a target for modulating feeding behaviors.

PI_NAMEs: FONTANINI, ALFREDO  (contact)

PROGRAM_OFFICER_NAME: SABRI, MERAV

PROJECT_TERMS: Acute;Address;Affect;Amygdaloid structure;Anatomy;Animals;Appetitive Behavior;Area;Automobile Driving;base;Behavior;Behavior Control;Behavioral;Behavioral Paradigm;behavioral response;Calcium;Cell Nucleus;Cells;cellular imaging;Consumption;Cues;Data;Desire for food;drinking;Electrophysiology (science);excitatory neuron;expectation;experimental study;feeding;Feeding behaviors;Gastrin releasing peptide;Glutamates;Head;Hunger;Image;imaging study;In Vitro;Infusion procedures;Interoception;Knowledge;Learning;Location;LoxP-flanked allele;Measures;Mediating;Methods;Modeling;Monitor;Mus;Nature;neural;neurochemistry;Neurons;Neuropeptides;neurotransmission;Neurotransmitters;novel;Nutrient;optogenetics;Output;patch clamp;Pattern;Peptides;pharmacologic;Pharmacology;Pharmacology Study;Play;Population;Process;Property;Reporter;Research;response;restraint;Rodent;Role;Satiation;Sensory;sensory integration;Shapes;Signal Transduction;Stimulus;Study models;Synapses;System;Taste Perception;Testing;Thirst;Time;Tracer;Transgenic Mice;transmission process;two-photon;Viral;Visualization;Work

PROJECT_TITLE: Functional role of Gastrin Releasing Peptide (GRP) and GRP expressing neurons in the gustatory cortex

STUDY_SECTION: NIC

STUDY_SECTION_NAME: Neuroscience of Interoception and Chemosensation Study Section[NIC]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: CHAPEL HILL

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE The need for rigorously trained infectious diseases epidemiologists has never been more evident than during the CoVID-19 pandemic of the past two years. The Training in Infectious Diseases Epidemiology (TIDE) T32 training program fills a unique and critical training niche in preparing academic and clinical researchers in interdisciplinary infectious diseases epidemiology. Funded for 15 years, we seeks to continue for another 5 years our work to train first-class academic and clinical infectious diseases epidemiology researchers to combat the infectious diseases of today and prepare for those of tomorrow.

PI_NAMEs: PENCE, BRIAN W (contact)

PROGRAM_OFFICER_NAME: SASTALLA, INKA I

PROJECT_TITLE: Training in Infectious Disease Epidemiology (TIDE)

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases Advisory Committee[MID]


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: NEWARK

ORG_DEPT: BIOLOGY

ORG_NAME: RUTGERS THE STATE UNIV OF NJ NEWARK

ORG_STATE: NJ

PHR: PROJECT NARRATIVE Peripheral demyelinating disease is a prevalent disorder of the PNS that affects myelin, and the prognosis of these diseases is poor with no available cure. Therefore, understanding the molecular mechanisms that regulate Schwann cell myelination and myelin repair is important for developing therapeutic strategies to improve the prognosis of the patients. Upon conclusion of the proposed study, we will 1) understand how choline, which is an important precursor to myelin membrane, is imported into Schwann cell, 2) understand how choline metabolism regulates Schwann cell myelination and 3) gain important insights into understanding the implication of choline metabolism in developing therapeutic strategies to treat peripheral demyelinating diseases.

PI_NAMEs: KIM, HAESUN A (contact)

PROGRAM_OFFICER_NAME: NUCKOLLS, GLEN H

PROJECT_TERMS: Affect;Anabolism;Biochemical;Carrier Proteins;Cells;Choline;choline transporter;Cytidine Diphosphate Choline;Defect;Demyelinating Diseases;Diet;dietary supplements;Disease;disease prognosis;DNA Methylation;DNA Modification Process;early onset;Epigenetic Process;epigenetic regulation;Exhibits;Feeds;Gene Expression;genetic approach;genome-wide;Goals;Hereditary Disease;histone methylation;histone modification;Histones;Homeostasis;Impairment;improved;insight;Knockout Mice;Lecithin;lipid metabolism;lipidomics;Lipids;Maintenance;Measures;Membrane;Metabolism;metabolomics;Methylation;Modification;Molecular;Mus;Myelin;Myelin Sheath;myelination;Nerve;Neuroglia;Neuropathy;Pathway interactions;patient prognosis;Peripheral;Peripheral Nervous System Diseases;Phenotype;Phosphatidylcholine Biosynthesis;Phosphatidylinositols;phosphoinositide-3,4,5-triphosphate;Phospholipids;Phosphorylation;Play;Positioning Attribute;Regulation;repaired;Research Personnel;Role;S-Adenosylhomocysteine;S-Adenosylmethionine;Schwann Cells;Signal Transduction;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;tandem mass spectrometry;Testing;Therapeutic;Washington;Wisconsin

PROJECT_TITLE: Choline-dependent metabolism in PNS myelination


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: In the 21st century the biomedical sciences will have ever increasing roles in improving health as well as acting as an engine of economic growth, so it is central to America's future to train the next generation of biomedical scientists. At the center of the biological revolution has been the understanding of basic cell mechanics using cell and molecular biology techniques. For 35 years the Cell and Molecular Biology graduate training program at the University of Virginia has turned out leaders in biological research that populate laboratories in companies, thinktanks and universities throughout the country. This has always been an inclusive program that has had over 20% of its trainees from under represented populations and produced outstanding graduation rates. This proposal outlines a bold restructuring of this program with the introduction of a number of student- centered activities to modernize our Ph.D. training program and to continue this proud training tradition.

PI_NAMEs: PASCHAL, BRYCE  (contact)

PROGRAM_OFFICER_NAME: HARTON, MARIE DEBORAHGAYNELLE

PROJECT_TITLE: Training in Cell and Molecular Biology

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - A[TWD-A]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences;Post-Traumatic Stress Disorder (PTSD)

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE Every day, humans and rodents alike are faced with opportunities to learn, store, and remember events. It is challenging to remember distinct events that are very similar, particularly under conditions of chronic stress. Neuroscience and clinical practice for memory dysfunction would both greatly benefit from understanding the brain circuitry that underlies this multi-stage discrimination of very similar events.

PI_NAMEs: EISCH, AMELIA J (contact)

PROGRAM_OFFICER_NAME: RANGEL GOMEZ, MAURICIO

PROJECT_TERMS: Adult;Age;Aging;Anatomy;behavior test;Behavioral;Behavioral trial;Biological;brain circuitry;Brain Diseases;Brain region;Cells;Chronic;Chronic stress;clinical practice;Cognition Disorders;combat;Data;dentate gyrus;Discrimination;discrimination task;Disease;Emotions;entorhinal cortex;Episodic memory;Event;Female;Fiber;Fright;Future;Genetic;Glutamates;granule cell;Hippocampus;Human;human imaging;Impaired cognition;Impairment;improved;indexing;insight;Knowledge;Lateral;Learning;Lesion;Link;Literature;Location;male;Mediating;member;Memory;Memory impairment;memory process;Modeling;Mus;neural;neural circuit;neural model;Neurons;Neurosciences;Opsin;optical fiber;Pathologic;Pattern;Performance;Play;Post-Traumatic Stress Disorders;Predisposition;Process;receptor;Resolution;Retrieval;Rodent;Rodent Model;Role;sex;Shapes;social defeat;Stimulus;Stress;stress related disorder;System;Testing;Therapeutic;touchscreen;Uncertainty;Viral;Virus

PROJECT_TITLE: Behavioral pattern separation: orchestration by lateral entorhinal cortex-hippocampal circuitry

STUDY_SECTION: BRLE

STUDY_SECTION_NAME: Biobehavioral Regulation, Learning and Ethology Study Section[BRLE]


ORG_CITY: MILWAUKEE

ORG_DEPT: BIOPHYSICS

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: PROJECT NARRATIVE Electron paramagnetic resonance (EPR) spectroscopy is a critically important technique in biomedical research with a unique ability to detect naturally occurring or engineered unpaired electrons in complex biological environments. I focus on the development of three technical and method developments that significantly improve X-band EPR sensitivity for three classes of samples: small to medium-sized (0.1–3 nl) protein single crystals, volume-limited frozen samples (85 nl), and microfluidic (500 nl) with microfluidic sample handling. The combination of these prototypes will be easy to use and widely available to the scientific community, enabling a wide range of new applications in biomedical EPR spectroscopy.

PI_NAMEs: SIDABRAS, JASON W (contact)

PROGRAM_OFFICER_NAME: BARNES, CHARLES ASHLEY

PROJECT_TERMS: absorption;Adopted;Adoption;Amplifiers;aqueous;Automobile Driving;Biological;Biology;Biomedical Research;Characteristics;clinical diagnostics;Communities;Complement;Complex;Computers;Coupling;cryogenics;Crystallography;Data Collection;design;Development;Directed Molecular Evolution;Drug Design;drug discovery;Electron Spin Resonance Spectroscopy;Electrons;Emerging Technologies;Engineering;Environment;Enzymes;experimental study;Ferredoxin;Fluorescence;Fluorescence Resonance Energy Transfer;Freezing;Frequencies;Geometry;Goals;Hemoglobin;high throughput screening;improved;innovation;instrumentation;magnetic field;Measures;Metalloproteins;method development;Methodology;Methods;Microfluidics;microwave electromagnetic radiation;Molecular;Monitor;Muramidase;nano;nanolitre;Noise;novel;Oxidation-Reduction;Performance;Physiologic pulse;Process;Protein Analysis;protein complex;protein structure function;Proteins;prototype;Publishing;Rapid screening;Research;Research Personnel;Sampling;Scanning;Scheme;Secondary Protein Structure;Signal Transduction;Site;Spin Labels;structural biology;Structure;Structure-Activity Relationship;System;Techniques;Technology;technology development;temporal measurement;Time;tool;transmission process;usability

PROJECT_TITLE: Emergent Technology for Studying the Structure/Function Relationship of Enzymes Using Electron Paramagnetic Resonance

STUDY_SECTION: EBIT

STUDY_SECTION_NAME: Enabling Bioanalytical and Imaging Technologies Study Section[EBIT]


NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Biomedical Imaging;Disability Research;Hearing Loss;Neurosciences;Prevention;Rehabilitation

ORG_CITY: PORTLAND

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Project Narrative Cochlear implants cause scarring in the ears of humans and rodents who subsequently can experience implantation induced hearing loss, but the processes causing this hearing loss are not fully understood. We will measure sound evoked vibrations inside implanted guinea pig ears, to understand how inner ear scarring impacts hearing, and also compare this data to 3D scans of the scarring in each inner ear. Understanding how scarring impacts remaining hearing mechanics following implantation will help to improve implants or develop treatments to prevent implant induced hearing loss.

PI_NAMEs: BURWOOD, GEORGE WILLIAM STRATHDEE (contact)

PROGRAM_OFFICER_NAME: MILLER, ROGER

PROJECT_TERMS: 3-Dimensional;Acoustic Nerve;Acoustic Stimulation;Acoustics;Acute;Affect;Animals;Apical;Basilar Membrane;Benchmarking;Cavia;Characteristics;Chronic;Cicatrix;Clinical;Cochlea;Cochlear implant procedure;Cochlear Implants;Complement;Computer Models;Coupled;Data;Decalcification;design;Detection;Development;Ear;Electric Stimulation;Electrocochleographies;Electrodes;Eligibility Determination;experience;experimental study;Exposure to;Fibrosis;Frequencies;Future;Goals;Hair Cells;Harvest;Hearing;hearing impairment;Hearing Tests;Histology;Human;Hybrids;Image;Image Analysis;image reconstruction;Immune;Implant;implantation;improved;insight;Interferometry;Labyrinth;Lead;Libraries;Link;Location;Loudness;Machine Learning;Maps;Measurement;Measures;mechanical behavior;mechanical properties;Mechanics;Metabolic;minimally invasive;Modeling;Morphology;multidisciplinary;Music;Nature;neurosensory;Noise;Noise-Induced Hearing Loss;Operative Surgical Procedures;Optical Coherence Tomography;Organ of Corti;Outer Hair Cells;Patients;Performance;Periodicals;Persons;Phase;Physiologic Ossification;Physiological;prevent;Process;Production;Prosthesis;Quality of life;Research;Residual state;response;Rodent;Rodent Model;Scala Tympani;Scanning;Signal Transduction;Site;sound;speech recognition;success;Techniques;Testing;Tissues;tool;Travel;vibration

PROJECT_TITLE: Changes in apical cochlear mechanics after cochlear implantation

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

ORG_CITY: STANFORD

ORG_DEPT: PHARMACOLOGY

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: NARRATIVE Although we now have the power to routinely sequence human genomes, most genetic variants discovered in patients are of uncertain consequence. Predictive models of complex traits, which are caused by large ensembles of genetic changes acting together, are therefore key to realizing the goals of personalized medicine. We propose to use a powerful genetic model system to build a mechanistic understanding of which variants impact complex traits and how they do so, with far-reaching implications for interpreting the functional consequences of genetic variation and for the diagnosis and treatment of disease.

PI_NAMEs: JAROSZ, DANIEL  (contact)

PROGRAM_OFFICER_NAME: ARGUELLO, ALEXANDER

PROJECT_TERMS: Affinity;Alleles;Amino Acid Sequence;Atlases;Biological;Biological Models;Biology;Biotechnology;Catalogs;causal variant;Cell model;cell type;Cellular biology;Chromosome Mapping;Classification;Collection;Complex;Diagnosis;Disease;disorder risk;DNA;DNA-Directed RNA Polymerase;Environment;Etiology;experimental study;Foundations;functional genomics;gene environment interaction;Gene Expression;Gene Expression Regulation;Genes;Genetic;genetic architecture;genetic manipulation;Genetic Models;Genetic Polymorphism;genetic variant;Genetic Variation;Genome;Genomic approach;genomic data;Genomics;Genotype;genotyped patients;Goals;Haplotypes;histone modification;human disease;Human Genome;Individual;insight;Intuition;Knowledge;Link;Maps;Measurement;Medical;Medicine;Messenger RNA;Missense Mutation;model organism;Modeling;Molecular;Mutation;Nucleosomes;Nucleotides;Open Reading Frames;Pathology;patient population;Patients;personalized medicine;Phenotype;Play;Positioning Attribute;precision medicine;predictive modeling;Property;Proteins;Proteomics;Reading;recruit;Resolution;Resources;RNA;RNA-Binding Proteins;Role;Saccharomyces cerevisiae;Saccharomycetales;segregation;Shapes;Structure;System;Technology;Testing;Time;Tissues;tool;training data;trait;Transcript;Transcription Initiation;transcriptomics;Translations;ultra high resolution;Validation;Variant;variant of unknown significance;Writing

PROJECT_TITLE: Mechanisms of Action of Natural Genetic Variation

STUDY_SECTION: GVE

STUDY_SECTION_NAME: Genetic Variation and Evolution Study Section[GVE]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Cancer;Genetics;Regenerative Medicine;Skin Cancer;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: LA JOLLA

ORG_DEPT: DERMATOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative Alterations in the growth and differentiation of epidermal stem and progenitor cells can lead to a variety of disorders including non-melanoma skin cancers as well as chronic wounds. Thus a comprehensive understanding of the mechanisms that regulate epidermal growth and differentiation is necessary to understand the progression to disease. This proposal seeks to characterize the mechanisms of epidermal self-renewal and differentiation through the regulation of mRNA export.

PI_NAMEs: SEN, GEORGE L (contact)

PROGRAM_OFFICER_NAME: KOCH, PETER

PROJECT_TERMS: 3-Dimensional;Adaptor Signaling Protein;Address;Basal cell carcinoma;Basement membrane;Binding;Binding Proteins;Cell Differentiation process;Cell Proliferation;Cells;chronic wound;clinically relevant;Clonal Expansion;Code;Complex;crosslinking and immunoprecipitation sequencing;Cytoplasm;Defect;Dermal;design;Differentiated Gene;Differentiation and Growth;Disease;DNA sequencing;embryonic stem cell;epidermal stem cell;Equilibrium;experimental study;Future;Gene Expression;Generations;Genes;Genetic Transcription;Growth;Homeostasis;Human;Immune;Immunoprecipitation;Impairment;knock-down;Lead;loss of function;loss of function mutation;Malignant Neoplasms;Mediating;Messenger RNA;Mitosis;Modeling;Molecular;mRNA Export;Mus;mutant;Mutate;Mutation;Natural regeneration;next generation sequencing;NOTCH1 gene;Nuclear Pore Complex;Pathway interactions;Phenotype;Play;pluripotency;posttranscriptional;Process;Proliferating;protein complex;Protein Export Pathway;Proteins;Psoriasis;Regulation;Research Design;RNA;RNA-Binding Proteins;Role;self-renewal;Skin;Skin Carcinoma;skin disorder;Specificity;Squamous cell carcinoma;stem;stem cell growth;stem cell self renewal;stem cells;Stratum Basale;Tissues;Transcript;transcription factor;transcriptome sequencing;Translating;Water

PROJECT_TITLE: Regulation of epidermal growth and differentiation through mRNA export

STUDY_SECTION: ACTS

STUDY_SECTION_NAME: Arthritis, Connective Tissue and Skin Study Section[ACTS]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Influenza;Lung;Pneumonia;Pneumonia and Influenza

ORG_CITY: PITTSBURGH

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: NARRATIVE  Influenza virus infects millions globally each year and in some cases is complicated with bacterial super-infection, which can result in severe illness and/or death. This study addresses the mechanisms by which influenza makes the lung more susceptible to later bacterial infection. This proposal defines the molecular pathways by which influenza leads to suppressed Staphylococcus aureus host defense and attempts to identify novel therapeutic targets to improve patient outcomes.

PI_NAMEs: ALCORN, JOHN F (contact)

PROGRAM_OFFICER_NAME: ESPINOZA-PINTUCCI, MARISOL

PROJECT_TERMS: Address;Age;Animal Model;Anti-Bacterial Agents;Anti-viral Agents;Anti-viral Therapy;Antibiotic Resistance;Antibiotics;Area;Attenuated;Bacterial Infections;Bacterial Pneumonia;Binding;Biological Assay;Bone Marrow;C Type Lectin Receptors;Cartoons;Cause of Death;CD209 gene;cell type;Cells;Cessation of life;Child;Childhood;Clinical;comorbidity;Complex;Coupled;cytokine;Data;Dimensions;disease model;Disease Outbreaks;Epithelial Cells;Etiology;Flow Cytometry;flu;Funding;global health;Goals;Hematopoietic;Host Defense;Human;immune activation;immune clearance;immune function;immune modulating agents;Immune response;Immunity;Impairment;improved;In Vitro;in vivo;Individual;Influenza;Influenza A virus;influenza infection;influenza pneumonia;influenzavirus;Interferon Type I;Interferon Type II;Interferons;Interleukin-1 beta;interleukin-23;Knockout Mice;Laboratories;Link;LoxP-flanked allele;Lung;lung injury;Mediating;Modeling;Molecular;monocyte;Morbidity - disease rate;mortality;mouse model;Mus;Neutrophil Infiltration;new therapeutic target;novel;Orthologous Gene;pandemic disease;pathogen;Pathway interactions;Patient Care;Patient-Focused Outcomes;Patients;Pattern recognition receptor;Persons;Phagocytes;Phagocytosis;Phagocytosis Inhibition;Pneumonia;polarized cell;Population;pre-clinical;Pre-Clinical Model;Predisposition;Prevalence;Publishing;receptor;receptor expression;Regulation;Risk Factors;Role;Seasons;Seminal;Signal Transduction;Staphylococcus aureus;Streptococcus pneumoniae;superinfection;T-Lymphocyte;Therapeutic;United States;uptake;vaccine access;Vaccines;Viral;Virus;Virus Diseases;Work

PROJECT_TITLE: Influenza A Inhibits TH17 Host Defense Against Bacterial Pneumonia

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Eye Disease and Disorders of Vision;Hypertension;Neurosciences

ORG_CITY: SHREVEPORT

ORG_DEPT: PHYSIOLOGY

ORG_NAME: LOUISIANA STATE UNIV HSC SHREVEPORT

ORG_STATE: LA

PHR: Approximately one-third of adults in the United States has hypertension, which can have severe consequences on the retina in the eye. This disease is called hypertensive retinopathy, which occurs in 25% of those with mild hypertension, and in 85% of those with severe hypertension. The disease involves changes in the blood vessels of the retina, which will be studied in the proposed work. We plan to identify the specific structural changes in the blood vessel wall that can be targeted in future treatments to protect vision.

PI_NAMEs: HARRIS, NORMAN R (contact)

PROGRAM_OFFICER_NAME: GORDIYENKO, NATALIYA

PROJECT_TERMS: Address;Adhesions;Adult;Affect;Angiotensin II;Anti-Hypertensive Agents;Area;arteriole;Basement membrane;Blood capillaries;Blood flow;Blood Platelets;Blood Pressure;blood pressure reduction;Blood Vessels;Blood-Retinal Barrier;cadherin 5;CD31 Antigens;Chronic;Collagen;collagenase;Connexin 43;cotton wool spots;Data;Dependence;Desmin;Development;Disease;driving force;E-Selectin;Endothelial Cells;endothelial dysfunction;Endothelin-1;Endothelium;Event;experimental study;Extracellular Matrix;Eye;Female;Fibronectins;Functional disorder;Future;Glycocalyx;Glycoproteins;Glypican;Gonadal Steroid Hormones;Health;Hemorrhage;Hypertension;hypertensive;Hypertensive Retinopathy;Hypoxia;Inbred SHR Rats;Inbred WKY Rats;KDR gene;Knowledge;Leukocytes;male;Mediator;Mesenchymal;Microcirculation;migration;Modeling;moesin;Molecular;muscle degeneration;N-Cadherin;Names;normotensive;novel;Optic Disk;optical disc;Oxygen;Pathologic;Pathway interactions;Perfusion;Pharmaceutical Preparations;pharmacologic;Phenotype;Platelet Glycoproteins;Population;Predisposition;pressure;Prevalence;prevent;Proteoglycan;Recovery;response;Retina;retina blood vessel structure;retina circulation;Retinal Artery Occlusion;Retinal Diseases;retinal neuron;Risk Factors;S100A4 gene;sex;Smooth Muscle;Smooth Muscle Myocytes;Surface;Swelling;syndecan;Testing;therapeutically effective;Thinness;Thrombus;United States;Vascular Cell Adhesion Molecule-1;Vasodilation;vein occlusion;Vimentin;Vision;von Willebrand factor receptor;women versus men;Work

PROJECT_TITLE: Retinal vasculature in hypertension

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 1 Study Section[PED1]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Homelessness;Mental Health;Pediatric;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: CAMBRIDGE

ORG_NAME: NATIONAL BUREAU OF ECONOMIC RESEARCH

ORG_STATE: MA

PHR: Project Narrative How health systems recover and respond in the face of major events, such as the COVID-19 pandemic, speaks to the structure of health systems and the policies that support them. The proposed study examines primary and mental health care to vulnerable and at-risk child populations (i.e., children with emotional disorders, children who experienced prior abuse, children in foster care, homeless children, and children who identify as LGBTQ+) during the pandemic, transition and recovery periods, in order to inform drivers of safety net system performance, policy improvement, and advance health equity.

PI_NAMEs: EVANS CUELLAR, ALISON  (contact)

PROGRAM_OFFICER_NAME: CHINN, JUANITA JEANNE

PROJECT_TERMS: Age;age group;Black, Indigenous, People of Color;care outcomes;Caring;Characteristics;Child;Childhood;Clinic;Clinical Data;Communities;community-level factor;comorbidity;Continuity of Patient Care;COVID-19 impact;COVID-19 pandemic;COVID-19 pandemic effects;COVID-19 prevalence;Data;design;Disease;Disparity;Drops;Economics;Electronic Health Record;Emergency department visit;Emotional disorder;Epidemic;ethnic disparity;Event;experience;falls;Family;flexibility;foster care;health care delivery;health care disparity;health equity;health inequalities;Health system;Healthcare Systems;Homeless Youth;Homelessness;Immunization;improved;Inequity;Information Systems;Lesbian Gay Bisexual Transgender Queer;Measures;Medicaid;medical specialties;Mental Health;Mental Health Services;Modeling;Neighborhood Health Center;Neighborhoods;novel;Outcome;pandemic disease;Patient-Centered Care;Patients;payment;Performance;Pharmaceutical Preparations;Policies;Population;Preventive service;Primary Health Care;Provider;Quality of Care;racial disparity;Recovery;Research;response;Rewards;Risk;safety net;school closure;screening;Shapes;Social isolation;stressor;Structure;System;Testing;Time;Uninsured;Vaccines;Visit;Vulnerable Populations;Well in self

PROJECT_TITLE: Impact of the COVID-19 Pandemic on Safety Net Performance, Disparities, and Vulnerable Children

STUDY_SECTION: HHD

STUDY_SECTION_NAME: Healthcare and Health Disparities Study Section[HHD]


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Hepatitis;Hepatitis - B;Infectious Diseases;Liver Disease

ORG_CITY: Chicago

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative Hepatitis B virus is a major human pathogen that replicates by reverse transcription of its pregenomic RNA within the viral capsid. Ten-eleven translocation (Tet) methylcytosine dioxygenases mediate the demethylation of HBV genomic DNA during liver development and therefore are essential for viral transcription, and hence replication, in vivo. A detailed understanding of the mechanism by which Tet-deficiency prevents viral biosynthesis without significantly altering liver physiology may permit the more effective design of antiviral therapies targeting this essential step in the viral life cycle. https://uic365-my.sharepoint.com/personal/mclach_uic_edu/Documents/Documents/MSword files/UIC/Grants/R01 Methylation 2/ProjectNarrative_Methylation_AMcL01.docx

PI_NAMEs: MCLACHLAN, ALAN  (contact)

PROGRAM_OFFICER_NAME: FLORES, AMANDA CHRISTINE

PROJECT_TERMS: acute liver disease;Adult;Anabolism;Anti-viral Therapy;Biological Models;bisulfite;Capsid;Cell Nucleus;Cell Therapy;cellular targeting;Cessation of life;Chromatin Structure;Chromosome Deletion;Chronic;Chronic Hepatitis B;chronic liver disease;Circular DNA;Clinical;Cytoplasm;demethylation;design;Development;Dioxygenases;DNA;DNA Methylation;DNA sequencing;effective therapy;Epigenetic Process;Gene Silencing;Genetic;Genetic Transcription;Genome;Genomic DNA;Genomics;Grant;Health;Hepatitis B Virus;Histones;human pathogen;in vivo;Individual;inhibitor therapy;Life Cycle Stages;Liver;liver development;liver function;LoxP-flanked allele;Mediating;Methylation;Molecular;Molecular Weight;mouse model;Mus;new therapeutic target;novel;novel strategies;Nuclear;Nucleotides;Physiological;Physiology;postnatal;Predisposition;prevent;Protein translocation;Proteins;recombinase;Regulation;Resolution;Reverse Transcription;RNA;Role;Signal Transduction;Suggestion;System;Tamoxifen;targeted treatment;therapeutic target;Transgenes;Transgenic Mice;Viral;Viral Genome;Viral Load result;Virus Diseases;Virus Inactivation;Virus Integration;Virus Replication

PROJECT_TITLE: Developmental regulation of HBV biosynthesis by Ten-eleven translocation (Tet) methylcytosine dioxygenases

STUDY_SECTION: VPI

STUDY_SECTION_NAME: Viral Pathogenesis and Immunity Study Section [VPI]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_NAME: HARVARD UNIVERSITY

PHR: Project Narrative Understanding the role of selection, gene flow, and mutations in the formation and divergence of species is a principal goal of evolutionary biology. This research investigates how selection and hybridization affect the genome during the process of speciation and adaptation, which is relevant to the NIH’s mission as hybridization with ancient hominins contributed to variation (some adaptive) in modern humans. Studying genomic variation in an organism for which manipulative field experiments and laboratory studies can verify the cause and effect of mutations is critical for a broader understanding of how evolutionary forces cause divergence and speciation in all organisms, including humans.

PI_NAMEs: HOPKINS, ROBIN  (contact)

PROGRAM_OFFICER_NAME: ADKINS, RONALD

PROJECT_TERMS: Affect;Biology;Candidate Disease Gene;Case Study;causal variant;Color;Comparative Genomic Analysis;cost;Environment;Evolution;experimental study;Flowers;Genes;Genetic;genetic analysis;genetic association;genetic variant;Genetic Variation;Genome;Genomic Segment;genomic variation;Genomics;Geography;Goals;Human;innovation;Investigation;Laboratory Study;Learning;Maps;Mission;Modernization;Molecular;Mutation;Natural Selections;novel;Organism;Pattern;Population Genetics;Process;programs;Psychological reinforcement;Recording of previous events;reproductive;Research;response;Role;Shapes;System;Time;Transgenic Organisms;United States National Institutes of Health;Validation;Variant;Vision;Work

PROJECT_TITLE: The genetics and genomics of reinforcement

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-U(55)R]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cannabinoid Research;Drug Abuse (NIDA only);Endocannabinoid System Research;Neurosciences;Opioid Misuse and Addiction;Opioids;Substance Misuse;Therapeutic Cannabinoid Research

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

PHR: Project Narrative Functional opioid  interactions between the endocannabinoid and opioid systems have been proposed to modulate  reward, although the underlying mechanisms are not well known. We propose here to studysynaptic, molecular and circuit mechanisms of how alterations in the endocannabinoid 2-AG control opioid reward in specific brain circuits.

PI_NAMEs: LEE, FRANCIS SANG YONG;RAJADHYAKSHA, ANJALI M (contact)

PROGRAM_OFFICER_NAME: LIN, YU

PROJECT_TERMS: 2-arachidonylglycerol;Analgesics;Animals;Arrestins;Attenuated;attenuation;Behavior;behavior measurement;Behavioral;Brain;Brain region;Calcium;cannabinoid receptor;Cannabinoids;Cell Nucleus;Cells;cellular imaging;Clinic;Complement;conditioned place preference;Cultured Cells;Dependence;desensitization;Detection;Development;Disease;Disinhibition;Dopamine;dopaminergic neuron;Down-Regulation;drug seeking behavior;Electron Microscopy;Electrophysiology (science);endocannabinoid signaling;Endocannabinoids;endogenous cannabinoid system;Enzymes;Fiber;Genetic;Heroin;in vivo;Inhibitory Synapse;Knock-out;male;Measurement;Measures;Mediating;Molecular;Monoacylglycerol Lipases;Morphine;mu opioid receptors;Mus;neural;Neuroanatomy;neurochemistry;Neurons;non-opioid analgesic;novel;novel therapeutic intervention;Nucleus Accumbens;Opiate Addiction;Opioid;Opioid agonist;opioid epidemic;opioid mortality;opioid use;opioid use disorder;Optics;optogenetics;Overdose;Oxycodone;oxycodone self-administration;Pain management;Pathway interactions;Persons;Pharmaceutical Preparations;pharmacologic;Photometry;preservation;presynaptic;Process;Property;Receptor Cross-Talk;Receptor Signaling;Regulation;reinforced behavior;Rewards;Role;Self Administration;Self Stimulation;Series;Slice;Synapses;System;Testing;tool;transmission process;United States;Ventral Tegmental Area

PROJECT_TITLE: Circuit and Synaptic Mechanisms of Endocannabinoid-Opioid Crosstalk

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Social Determinants of Health;Substance Misuse

ORG_CITY: KINGSTON

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF RHODE ISLAND

ORG_STATE: RI

PHR: Project Narrative By asking people to report their behaviors, feelings, and social context in nearly real time, ecological momentary assessment (EMA) helps researchers better understand the causes of drug use so that just-in-time intervention strategies could be developed. However, EMA data are often partially missing, increasing the risks of drawing invalid research conclusions and developing ineffective interventions. Using simulated and existing data in a cost-effective way, the current study develops novel statistical methods to deal with missing data in EMA, which inform the development of better drug use interventions.

PI_NAMEs: YANG, MANSHU  (contact)

PROGRAM_OFFICER_NAME: KURAMOTO-CRAWFORD, SATOKO JANET

PROJECT_TERMS: Address;Adoption;Affect;Alcohol consumption;Alcohols;Area;Bayesian Analysis;Bayesian Method;Bayesian Modeling;Behavior;behavioral health;Cannabis;career;career development;Career Mobility;Characteristics;Code;Complement;Complex;Computers;contextual factors;cost;cost effective;Data;Data Analyses;Data Collection;data handling;data management;Data Set;Dedications;design;Development;Development Plans;Doctor of Philosophy;Drug Addiction;Drug usage;Ecological momentary assessment;effective intervention;efficacious intervention;Emotions;Environment;Etiology;Evaluation;experience;Feeling;Functional disorder;Funding;Goals;Health Psychology;Heavy Drinking;Hour;improved;Intervention;intimate partner violence;Knowledge;Longitudinal Studies;Mandatory Reporting;Marijuana;marijuana use;marijuana user;Measurement;Mentored Research Scientist Development Award;Mentorship;method development;Methodology;Methods;Names;National Institute of Drug Abuse;National Research Council;novel;Participant;Pattern;Persons;Pharmaceutical Preparations;Prevention strategy;Process;professor;programs;psychological symptom;Psychology;psychosocial;Psychosocial Factor;Psychosocial Influences;Public Health;Publications;Recommendation;Reporting;Reproducibility;Research;Research Personnel;research study;response;Retrieval;Rhode Island;Risk;Schedule;skills;smartphone application;Smoking;social;Social Environment;Statistical Data Interpretation;Statistical Methods;statistics;substance use;Surveys;System;Target Populations;Techniques;Technology;Testing;theories;Time;Tobacco;Training;Trauma;treatment strategy;Universities;university student;Work

PROJECT_TITLE: Improving Methods for Dealing with Missing Data in Drug Use and Addiction Research: The Use of Later-Retrieval in Ecological Momentary Assessment

STUDY_SECTION: ASPB

STUDY_SECTION_NAME: Analytics and Statistics for Population Research Panel B Study Section[ASPB]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Endocrine Disruptors;Estrogen;Genetics;Human Fetal Tissue;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: PULLMAN

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: WASHINGTON STATE UNIVERSITY

ORG_STATE: WA

PHR: PROJECT NARRATIVE Chromosomally abnormal pregnancies are the leading cause of miscarriage and birth defects. Most errors leading to chromosomally abnormal conceptions occur during egg development and their incidence is strongly influenced by maternal age. This project will make use of data amassed during ten-plus years of collaborative studies of human fetal ovaries to enhance our understanding of the earliest stages of oogenesis and test the hypothesis that disturbances that predispose to chromosomally abnormal eggs are increased by fetal exposure to manmade endocrine disrupting chemicals (EDCs).

PI_NAMEs: HASSOLD, TERRY J;HUNT, PATRICIA  (contact)

PROGRAM_OFFICER_NAME: TAYMANS, SUSAN

PROJECT_TERMS: Adult;Affect;Aneuploidy;Biological Monitoring;bisphenol A;Cell Cycle Regulation;Characteristics;Chemical Exposure;Chemicals;Chromatin;Chromosome abnormality;Chromosome Pairing;Chromosomes;Circulation;cohort;Cohort Analysis;Conceptions;Congenital Abnormality;Data;Databases;design;Development;egg;Endocrine Disruptors;Endogenous Factors;Environment;Environmental Exposure;Environmental Risk Factor;Event;Exhibits;Exogenous Factors;exposed human population;Exposure to;Failure;fascinate;Female;fetal;Fetal Development;Fetus;Frequencies;Generations;Genetic;Genetic Nondisjunction;Genetic Recombination;Genetic Variation;Genotype;Germ Lines;Homologous Gene;Human;human female;Incidence;Individual;insight;inter-individual variation;Laboratories;Length;man;Maternal Age;Maternal Exposure;Meiosis;Meiotic Recombination;Metabolic;Methods;Nature;Oocytes;Oogenesis;Ovary;Pathway interactions;Phenotype;phthalates;Placenta;placental transfer;Predisposition;Pregnancy;prenatal exposure;Prophase;Resources;Sampling;Serum;Spontaneous abortion;stem;Synaptonemal Complex;Testing;Urine;Variant;Work

PROJECT_TITLE: The impact of genetic and environmental factors on meiotic prophase in the human female

STUDY_SECTION: CMIR

STUDY_SECTION_NAME: Cellular, Molecular and Integrative Reproduction Study Section[CMIR]


ORG_CITY: BOSTON

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: Project Narrative (Public Health Relevance) Heart failure with preserved ejection fraction (HFpEF) is associated with a high burden of morbidity and mortality, yet contributing factors are incompletely understood and no effective therapies exist to date. The goal of this proposal is to train new investigators in clinical research methods in order to learn more about the pathogenesis of HFpEF.

PI_NAMEs: HO, JENNIFER E (contact)

PROGRAM_OFFICER_NAME: WEBB, STEPHANIE JOHNSON

PROJECT_TERMS: Address;adjudication;Adverse event;Affect;Analytical Chemistry;Area;Attention;Award;Biochemical;Bioinformatics;Blood Vessels;Body System;cardiometabolism;Cardiopulmonary;Cardiopulmonary Physiology;Cardiovascular system;career;career development;Classification;Clinical;clinical epidemiology;clinical heterogeneity;Clinical Investigator;Clinical Research;cohort;Collaborations;Communities;Complex;Coupled;Coupling;Development;disease phenotype;disorder prevention;education resources;effective therapy;EFRAC;Environment;Exercise;Exercise Physiology;Exercise Test;Fellowship Program;Foundations;Functional disorder;Funding;Future;General Hospitals;Goals;Heart;Heart failure;hemodynamics;Hospitals;Human;Individual;Inflammatory;Inflammatory Response;Infrastructure;Insulin Resistance;Interdisciplinary Study;interest;International;Investigation;Knowledge;Laboratories;Learning;Link;Lung;Massachusetts;Medicine;men;Mentors;Mentorship;Metabolic Diseases;Metabolic dysfunction;Mid-Career Clinical Scientist Award (K24);Monitor;Morbidity - disease rate;mortality;Obesity;optimal treatments;Outcome;outcome prediction;Pathogenesis;Pathway interactions;patient oriented;patient oriented research;Patients;Phenotype;Physiological;preservation;Prevention therapy;Productivity;programs;prospective;Prospective Studies;Public Health;public health relevance;Public Health Schools;Pulmonary Hypertension;recruit;Research;Research Methodology;Research Personnel;Research Support;Research Training;Resources;Right Ventricular Function;Risk Factors;Role;Sampling;Seminal;Sex Differences;systemic inflammatory response;Therapeutic;Training;training opportunity;Translational Research;translational research program;translational study;United States National Institutes of Health;Universities;Ventricular;Woman;women versus men;Work

PROJECT_TITLE: Mentoring in Patient-Oriented and Translational HFpEF Research


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Opioid Misuse and Addiction;Opioids;Social Determinants of Health;Substance Misuse

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PROJECT NARRATIVE State and federal policymakers have expanded access to residential treatment for substance use disorder (SUD) in the Medicaid program, broadening access to the full continuum of care, increasing the capacity in the greater SUD treatment system, and potentially spurring patients to seek care for an SUD. This project will examine the relationship between increasing coverage for residential treatment services among Medicaid beneficiaries with opioid use disorder and explore the implications of co-morbid SUDs. Through the proposed research and training in this Mentored Research Scientist Career Development Award, I will gain the additional skills and knowledge to pursue innovative, independent research to improve access to care and health outcomes for people with SUD in the U.S.

PI_NAMEs: FRY, CARRIE ELIZABETH (contact)

PROGRAM_OFFICER_NAME: SU, SHELLEY

PROJECT_TERMS: Accident and Emergency department;addiction;Address;Adult;Affect;Ambulatory Care;American;beneficiary;care seeking;career;Categories;Collaborations;comorbidity;Continuity of Patient Care;cost;Cost Sharing;Coupled;Data;Doctor of Philosophy;Elements;Eligibility Determination;Emergency department visit;Equipment and supply inventories;Evaluation;evidence base;Evidence based treatment;experience;federal policy;flexibility;follow-up;Future;Glean;Goals;Grant;Health;health care availability;Health Policy;Health Services;Health Services Accessibility;Improve Access;improved;Incidence;informant;innovation;insight;interest;Interview;K-Series Research Career Programs;Knowledge;learning network;Low income;Managed Care;marginalization;marginalized community;Measurement;Measures;Medicaid;medical schools;medication for opioid use disorder;Medicine;Mental disorders;Mentors;Modality;Monitor;opioid use disorder;Outcome;Overdose;overdose death;Patients;Pattern;Personal Satisfaction;Persons;Policies;Policy Maker;Policy Making;Population;Prevalence;professor;programs;Quasi-experiment;Regulation;Research;Research Personnel;Residential Treatment;Risk;Role;Sampling;Scientist;skills;Social outcome;Structure;substance use;Substance Use Disorder;Surveys;System;Time;tool;Training;treatment services;United States;Universities;Variant;waiver;Work

PROJECT_TITLE: Opioid Use Disorder and Residential Treatment in Medicaid

STUDY_SECTION: ODHS

STUDY_SECTION_NAME: Organization and Delivery of Health Services Study Section[ODHS]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Biomedical Imaging;Cancer;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Lung Cancer;Prevention;Primary Health Care;Rural Health;Social Determinants of Health;Tobacco;Tobacco Smoke and Health

ORG_CITY: Columbus

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE Lung cancer causes nearly as many deaths as the number of deaths resulting from breast, cervical, colorectal, and prostate cancers combined and rural areas are disproportionately impacted, but knowledge to inform effective interventions is limited. In this project, we will examine the uptake of bundled evidence-based interventions for prevention and early detection, examine the occurrence of modifiable gaps in the care received, and then conduct interviews with patients and healthcare professional to further understand why death rates may be higher in rural than urban areas. The innovative approaches we propose in socioeconomically diverse populations will allow us to inform interventions that can substantially improve outcomes in many communities.

PI_NAMEs: DOUBENI, CHYKE ABADAMA (contact)

PROGRAM_OFFICER_NAME: WEAVER, SALLIE JAYNE

PROJECT_TERMS: Address;aged;Area;cancer care;Cancer Control;Cancer Death Rates;cancer diagnosis;Cancer Etiology;cancer health disparity;Caring;Censuses;Cessation of life;Classification;Clinic;Clinical;Code;cohort;Cohort Studies;Colorectal Cancer;Communities;Commuting;Continuity of Patient Care;County;COVID-19;COVID-19 impact;COVID-19 pandemic;Data;data resource;Databases;Death Rate;Dimensions;disorder risk;Disparity;Early Diagnosis;effective intervention;Eligibility Determination;Epidemiology;epidemiology study;Equity;Evidence based intervention;Federally Qualified Health Center;follow-up;Future;Goals;Guidelines;health care availability;Health care facility;health equity;Health Professional;Health Services Accessibility;Health system;Healthcare;high risk;improved outcome;Individual;Information Systems;innovation;Intervention;Interview;Knowledge;lens;low dose computed tomography;lung cancer prevention;lung cancer screening;Malignant Breast Neoplasm;Malignant neoplasm of cervix uteri;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant Neoplasms;Measures;men;Methods;mortality;mortality risk;novel;novel coronavirus;Older Population;Patient Self-Report;Patients;Persons;Policies;population based;Population Heterogeneity;President's Cancer Panel;preventable death;preventive intervention;Primary Care;Process;promote resilience;promoter;Race;Recommendation;Reporting;Research;Risk Assessment;Risk Factors;Risk Reduction;Role;Rural;rural area;Rural Population;rurality;Scientist;screening;Screening for cancer;Screening Result;Series;shared decision making;Site;Smoking;smoking cessation;Smoking Cessation Intervention;smoking prevalence;social;Social Environment;social factors;social stigma;socioeconomic disadvantage;Socioeconomic Factors;Socioeconomic Status;socioeconomics;Structure;study population;System;Taxonomy;Translating;Travel;United States National Institutes of Health;United States Preventative Services Task Force;uptake;urban area;urban disparity;Urban Population;Variant;Woman;X-Ray Computed Tomography

PROJECT_TITLE: Promoting Equity of Cancer Screening and Follow-up for Lung Cancer

STUDY_SECTION: CHSA

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology A Study Section[CHSA]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Asthma;Lung

ORG_CITY: BALTIMORE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: NARRATIVE  Allergen-induced inflammation and increases in the amount of airway smooth muscle, fibroblasts, and extracellular matrix in the lung occur in asthma and contribute to disease progression and severity. We have identified a novel compound that selectively inhibits signaling molecules critical in the pathogenesis of asthma. Studies proposed in this application will use structure-guided computer-aided drug design to optimize the pharmacological properties of this compound and its ability to inhibit pathological features of asthma providing a framework for developing a new class of anti-asthma drugs and treatment.

PI_NAMEs: DESHPANDE, DEEPAK A;SHAPIRO, PAUL S (contact)

PROGRAM_OFFICER_NAME: LU, JINING

PROJECT_TERMS: acquired drug resistance;adduct;airway hyperresponsiveness;airway inflammation;airway remodeling;Allergens;analog;Anti-Asthmatic Agents;Asthma;asthma model;asthmatic;Binding;Binding Sites;Biological Availability;Biological Sciences;Bronchoconstriction;Cardiotoxicity;Cell Line;Cell Physiology;Cell Proliferation;cell type;Cells;chemical synthesis;Chemicals;Chronic;Collaborations;Complex;Computer Assisted;Cysteine;cytokine;Data;design;Disease Progression;Docking;Drug Design;Drug Kinetics;Drug resistance;Drug Targeting;Drug toxicity;efficacy evaluation;Enzymes;Evaluation;extracellular;Extracellular Matrix;Extracellular Signal Regulated Kinases;Extrinsic asthma;Family;Fibroblasts;Genetic Transcription;Growth Factor;Heterogeneity;Human;Hyperplasia;Hypertrophy;Immune;Immunologics;improved;In Vitro;in vivo;in vivo Model;Inflammation;Inflammation Mediators;Inflammatory;Inflammatory Response;inhibitor;innovation;Intravenous;kinase inhibitor;Lead;Ligands;Lung;MAPK1 gene;MAPK3 gene;MAPK7 gene;MAPK8 gene;Mass Spectrum Analysis;Mediating;Mediator;Methods;Mitogen-Activated Protein Kinases;Morbidity - disease rate;mouse model;Mus;Normal Cell;novel;novel therapeutics;Obstructive Lung Diseases;Oral;p38 Mitogen Activated Protein Kinase;Pathogenesis;Pathologic;Pathology;PDGF inhibition;Persons;Pharmaceutical Preparations;pharmacologic;Pharmacology and Toxicology;Phase;Phosphotransferases;pre-clinical;preclinical development;preclinical study;Preclinical Testing;prevent;Proliferating;Property;protein complex;Protein Kinase;Proteins;pulmonary function;Pyroglyphidae;Quality of life;rational design;Regulation;respiratory smooth muscle;scaffold;Scanning;Severity of illness;Signal Pathway;Signal Transduction;Signaling Molecule;Site;Slice;Smooth Muscle Myocytes;Solubility;STAT protein;Structure;Surface Plasmon Resonance;Technology;Testing;Therapeutic;Therapeutic Agents;therapeutic target;Tissues;Toxic effect;Toxicology;transcription factor;Transcription Factor AP-1;Western Blotting

PROJECT_TITLE: Optimizing function-selective ERK1/2 inhibitors for reducing AP-1-mediated airway pathology in asthma.


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Aphasia;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Rehabilitation;Stroke

ORG_DEPT: PHYSICAL MEDICINE & REHAB

ORG_NAME: THOMAS JEFFERSON UNIVERSITY

PHR: PROJECT NARRATIVE  It is estimated that between 2.5 and 4 million Americans are living with aphasia today – a primary disorder of spoken and written language. This project addresses common problems experienced by people with aphasia, including difficulty retrieving known words for production, and problems retrieving the meanings of words. The proposed studies aim to elucidate how powerful learning principles derived from basic psychological research can be leveraged to confer maximal, sustained improvements in the naming or comprehension of treated words in people with aphasia.

PI_NAMEs: MIDDLETON, ERICA LEE (contact)

PROGRAM_OFFICER_NAME: STORKEL, HOLLY LYNN

PROJECT_TERMS: Address;Affect;Aftercare;American;Anatomy;Aphasia;aphasia rehabilitation;Brain imaging;Categories;Chronic;clinical application;clinically relevant;Comprehension;comprehension deficit;Dedications;design;Development;Disease;dosage;Dose;Drops;Elements;experience;feasibility trial;Feedback;Future;Gestures;Goals;Grouping;Guidelines;Home;Impairment;improved;improved outcome;Individual Differences;individualized medicine;Language;Learning;Left;Measures;Memory;Methods;Names;National Institute on Deafness and Other Communication Disorders;Outcome;Participant;Pathologist;Persons;Phase;Preparation;Production;programs;Protocols documentation;psychologic;Randomized, Controlled Trials;Regimen;Research;Research Design;Retrieval;Schedule;Semantics;Speech;Stroke;Symptoms;System;Techniques;theories;Training;treatment response;trend;Vocabulary;Word Processing;Work;Writing

PROJECT_TITLE: Retrieval Practice Principles: A Theory of Learning for Aphasia Rehabilitaion

STUDY_SECTION: LCOM

STUDY_SECTION_NAME: Language and Communication Study Section[LCOM]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Biotechnology

ORG_CITY: RALEIGH

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: NORTH CAROLINA STATE UNIVERSITY RALEIGH

PHR: Project Narrative Advanced training in molecular biotechnology is critical to modern biomedical science research and should be a key component of pre-doctoral education for students aspiring to academic, industrial, and government research careers. This training should be done in an inclusive environment and complemented by an appreciation of responsible conduct of research and scientific rigor and reproducibility. Furthermore, students should be given opportunities for professional development through a variety of mechanisms, including workshops and internships.

PI_NAMEs: HAUGH, JASON M. (contact);KELLY, ROBERT M

PROGRAM_OFFICER_NAME: DAVANI, BEHROUS

PROJECT_TITLE: NC STATE MOLECULAR BIOTECHNOLOGY TRAINING PROGRAM (MBTP)

STUDY_SECTION_NAME: Training and Workforce Development Study Section - B[TWD-B]


NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease;Regenerative Medicine

ORG_CITY: COLUMBUS

ORG_NAME: RESEARCH INST NATIONWIDE CHILDREN'S HOSP

PHR: PROJECT NARRATIVE Adult mammalian heart is one of least regenerative organs. In this study, we will test whether manipulation of histone deacetylase 7 may promote adult cardiomyocyte proliferation and understand the potential underlying mechanisms. Our new findings will shed new light on how to promote heart regeneration, ultimately find a new treatment for heart failure.

PI_NAMEs: LI, DEQIANG  (contact)

PROGRAM_OFFICER_NAME: TJURMINA, OLGA A

PROJECT_TERMS: Adult;Aging;Apical;Biochemistry;Blood Vessels;c-myc Genes;Cardiac;Cardiac Myocytes;cardiac regeneration;cardiac repair;cardiogenesis;Cell Cycle;Cell division;Cell Nucleus;Chromatin;Chromatin Remodeling Factor;comparative;Cytoplasm;Data;Development;Developmental Biology;Disease;Drug or chemical Tissue Distribution;Embryo;Epigenetic Process;Epithelium;Excision;experimental study;Goals;Growth;Heart;Heart Diseases;Heart failure;heart function;Histone Deacetylase;Human;Impairment;improved;in vivo;Induced Cardiomyocytes;knock-down;Knock-out;Malignant Neoplasms;Measures;Molecular Biology;Morbidity - disease rate;mortality;mouse genetics;Mus;Myocardial;Myocardial Infarction;myocardial injury;myocyte-specific enhancer-binding factor 2;Natural regeneration;Neonatal;neonatal mice;novel;Nuclear;Organ;organ growth;Outcome;overexpression;Pathologic;Pathologic Processes;Physiological Processes;Polyploidy;postnatal;Process;Proliferating;Recovery;regeneration potential;regenerative;Regenerative Medicine;response;Role;Signal Transduction;Testing;Therapeutic;therapeutically effective;transcriptome sequencing;transcriptomics;tumor growth;Zebrafish

PROJECT_TITLE: Cardiac regeneration by histone deacetylases

STUDY_SECTION: CDD

STUDY_SECTION_NAME: Cardiovascular Differentiation and Development Study Section[CDD]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative  Drugs of abuse usurp and modify communication between different types of neurons within defined circuits in the brain, resulting in stable changes in the expression and activities of proteins (the “neuroproteome”) required for normal neuronal function. Improving our understanding of how drugs of abuse alter the distinct neuroproteomes of the specific neuronal sub-types that define the circuits that underlie the actions and addictive properties of drugs of abuse will provide deeper insight into the molecular basis of drug addiction and thus help in the design of new and more effective therapeutic strategies.

PI_NAMEs: NAIRN, ANGUS C.;WILLIAMS, KENNETH ROBERT (contact)

PROGRAM_OFFICER_NAME: POLLOCK, JONATHAN D

PROJECT_TERMS: addiction;Address;Affinity;Alleles;Area;Behavioral;Bioinformatics;Biological Assay;Biological Markers;biological systems;Biology;Biometry;biophysical analysis;Biophysics;Biotechnology;Biotinylation;Brain;Brain Chemistry;Brain region;Cannabis;career;cell type;Cells;Central Nervous System;Cocaine;Collaborations;combinatorial;Communication;comparative;Country;Data;design;Development;Drug abuse;drug action;Drug Addiction;drug of abuse;Environment;Epigenetic Process;Exposure to;Faculty;Fluorescence-Activated Cell Sorting;Fostering;Foundations;Future;Gene Expression;Genomics;Goals;Group Affiliation;Heterogeneity;High Performance Computing;histone modification;improved;in vitro Assay;Individual;innovation;insight;Institution;interest;Kinetics;Laboratories;Lasers;Ligands;Lipids;Medical Libraries;Mentors;method development;Methodology;Methods;Microscopy;Molecular;Monitor;National Institute of Drug Abuse;neural;Neurobiology;Neurologic;Neurons;neuropathology;neuroproteomics;neurotransmission;Nicotine;novel;novel strategies;Opioid;optogenetics;Organelles;Peptides;Pharmaceutical Preparations;Phosphatidylinositols;Pilot Projects;Play;Post Translational Modification Analysis;Post-Translational Protein Processing;Postdoctoral Fellow;Process;Program Research Project Grants;programs;Property;protein expression;protein profiling;Proteins;Proteome;Proteomics;Psychiatry;Puromycin;Reaction;Reagent;Records;Regulation;Research;Research Personnel;Research Project Grants;Resources;response;Rewards;Scientist;Signal Pathway;Signal Transduction;Signaling Protein;Specificity;Structure;Substance abuse problem;Substance of Abuse;synergism;System;Techniques;Technology;technology development;therapeutically effective;Thermodynamics;tool;Training;transcriptomics;Translations;translatome;virtual;Work

PROJECT_TITLE: Yale/NIDA Neuroproteomics Center


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Drug Abuse (NIDA only);Neurosciences;Substance Misuse

PI_NAMEs: WILLIAMS, KENNETH ROBERT (contact)

PROJECT_TERMS: addiction;authority;base;Biotechnology;Brain;Brain Chemistry;Budgets;Collaborations;Communication;Databases;Development;Disputes;drug action;Drug Addiction;drug of abuse;Ensure;Exposure to;Fostering;Funding;Future;Gene Expression;Goals;improved;Infrastructure;innovation;Institution;instrumentation;Leadership;medical schools;meetings;member;Methodology;Mission;National Institute of Drug Abuse;neuroproteomics;neurotransmission;operation;Pilot Projects;Play;Post-Translational Protein Processing;Procedures;Process;Program Research Project Grants;programs;Proteins;Proteomics;Publications;Qualifying;Quality Control;recruit;Regulation;Research;Research Activity;Research Personnel;Research Support;Research Training;Resources;response;Rewards;Role;service utilization;Signal Transduction;Signaling Protein;Specialist;Structure;System;Technology;tool;Training;Training and Education;Translations;Twitter;United States National Institutes of Health;virtual environment;web site

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Drug Abuse (NIDA only);Substance Misuse

PI_NAMEs: LAM, TUKIET T (contact)

PROJECT_TERMS: addiction;Binding;Bioinformatics;Biological;Biological Assay;Biometry;biophysical analysis;Biophysics;Biotechnology;Brain;Brain region;Carrier Proteins;cell type;Cells;Chemicals;Circular Dichroism;Collaborations;combinatorial;Complex;Computer software;Computers and Advanced Instrumentation;Data;Data Analyses;Data Set;Databases;design;Development;differential expression;Digestion;drug action;Drug Addiction;drug of abuse;Ensure;Enzymes;Epigenetic Process;Experimental Designs;Exposure to;Field Flow Fractionation;Fluorescence Resonance Energy Transfer;Fractionation;Generations;Glycopeptides;glycosylation;histone modification;holistic approach;Immunologics;improved;Individual;Information Dissemination;innovation;interest;Ions;Kinetics;Label;Lectin;Libraries;Licensing;Ligands;light scattering;lipid transport;lipidomics;Lipids;Liquid substance;Mass Spectrum Analysis;Medical Libraries;Membrane;Metabolism;Methodology;Methods;microcalorimetry;Monitor;National Institute of Drug Abuse;neuroproteomics;neurotransmission;Nucleic Acids;Organelles;Output;overexpression;Peptides;Phosphatidylinositols;Phosphopeptides;polypeptide;Post Translational Modification Analysis;Post-Translational Modification Site;Post-Translational Protein Processing;Postdoctoral Fellow;Preparation;programs;protein complex;protein expression;protein function;protein profiling;Proteins;Proteome;Proteomics;Reaction;Recombinant Proteins;Research;Research Personnel;Resolution;response;Sampling;scaffold;Scheme;Signal Transduction;Site;small molecule;Spottings;Students;Surface Plasmon Resonance;System;Techniques;Technology;Thermodynamics;Time;Tissues;titanium dioxide;tool;Training;transcriptome sequencing;Vendor;Visualization;Work

PROJECT_TITLE: Discovery Proteomics Core


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Immunization;Infectious Diseases;Lung

ORG_CITY: SAN DIEGO

ORG_NAME: APPLIED BIOMEDICAL SCIENCE INSTITUTE

PHR: Project Narrative The SARS-CoV-2 virus is a pandemic causing widespread COVID-19 respiratory disease and death globally. We have discovered that cow antibody CDR H3 “knob” domains can be made as independent small peptides, and have identified several such peptides that potently bind and neutralize the SARS-CoV-2 virus and its variants, including delta and omicron. We aim to discover a larger panel of these knob peptides and evaluate their efficacy as single agents, cocktails, and bispecific molecules on SARS-CoV-2 neutralization; this work could impact the current SARS-CoV-2 outbreak, as well as future novel coronavirus outbreaks.

PI_NAMEs: SMIDER, VAUGHN VASIL (contact)

PROGRAM_OFFICER_NAME: BASU, DIPANWITA

PROJECT_TERMS: 2019-nCoV;Affinity;Animals;Anti-viral Agents;Antibodies;Antibody Binding Sites;Antibody Response;Antigens;Binding;Cattle;Cessation of life;Clinical;Combined Modality Therapy;Coronavirus;coronavirus disease;coronavirus pandemic;Coronavirus spike protein;COVID-19;COVID-19 outbreak;COVID-19 pandemic;cross reactivity;Disease;disease model;Disease Outbreaks;Distant;disulfide bond;Disulfides;Electron Microscopy;Enzyme Inhibition;Epitopes;Escherichia coli;Evolution;Fab Immunoglobulins;Future;future pandemic;G-Protein-Coupled Receptors;Genetic Variation;glycosylation;Goals;HIV;Human;Immunity;Immunize;In Vitro;in vitro activity;in vivo;Infection;Inhalation;inhibitor;Ion Channel;Length;Libraries;Light;Lung Diseases;manufacture;microbial;Middle East Respiratory Syndrome;Middle East Respiratory Syndrome Coronavirus;Molecular;Molecular Evolution;Monoclonal Antibodies;nanomolar;neutralizing antibody;novel;novel coronavirus;novel drug class;novel therapeutics;Organism;pandemic disease;Parents;Passive Immunotherapy;Patients;Pattern;Peptide Hydrolases;Peptides;pharmacologic;Plants;Production;Property;prophylactic;Prophylactic treatment;Proteins;Resistance;Respiratory Disease;Risk;Rodent Diseases;Route;SARS coronavirus;SARS-CoV-2 variant;Serum;Severe Acute Respiratory Syndrome;severe COVID-19;small molecule;Stress;System;targeted treatment;Techniques;Technology;Therapeutic;therapeutic development;Therapeutic Monoclonal Antibodies;tool;transmission process;Variant;variants of concern;Venoms;Viral;Viral Physiology;Virus;Work;X-Ray Crystallography

PROJECT_TITLE: Broadly neutralizing SARS-CoV-2 peptidic knobs

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DCAI-B(81)]


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Data Science

ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PI_NAMEs: PETER, INGA  (contact)

PROGRAM_OFFICER_NAME: MERCHANT, CAROL

PROJECT_TERMS: Academic skills;Acceleration;Area;Big Data;biobank;Biomedical Research;Biometry;career;career development;Child Health;Clinical;Clinical Data;clinical translation;Clinical Trials;cohort;Communication;community engagement;Competence;Complex;conflict resolution;course development;data resource;Data Science;Data Scientist;Data Set;design;Development Plans;Discipline;Disease;diversity and inclusion;drug discovery;Educational Curriculum;Educational process of instructing;Educational workshop;Entrepreneurship;Environment;Epidemiology;Ethics;experience;Exposure to;Face;Faculty;Future;Generations;Genomics;Goals;Grant;Growth;Guidelines;Health;improved;Individual;Industry;Informatics;innovation;Institution;Life Cycle Stages;life span;Mediation;Mentors;Methodology;Methods;Modern Medicine;Modernization;National Center for Advancing Translational Sciences;Outcome;Preparation;Process;Productivity;Program Development;programs;promote resilience;Research;research and development;Research Design;research study;Science;Scientist;skills;Training;Training Programs;Translation Process;Translational Research;translational scientist;Workforce Development;Writing

PROJECT_TITLE: Institutional Career Development Core


NIH_SPENDING_CATS: Biotechnology;Drug Abuse (NIDA only);Neurosciences;Substance Misuse

PROJECT_TERMS: Address;adeno-associated viral vector;animal tissue;Antibodies;Binding;Biological Assay;Biological Markers;Biotinylation;Brain;Brain region;brain tissue;Cell Nucleus;cell type;Cells;Central Nervous System;Collaborations;comparative;Corpus striatum structure;DARPP;Data;Data Analyses;design;detection sensitivity;differential expression;Digestion;drug of abuse;Emerging Technologies;Experimental Designs;Exposure to;Genetic Transcription;Genomics;Goals;Heterogeneity;Human;improved;in vivo;instrument;interest;Label;Laboratories;Libraries;Literature;mass spectrometer;Mass Spectrum Analysis;member;Methodology;Mitochondria;Modeling;Monitor;Multiprotein Complexes;Mus;National Institute of Drug Abuse;Neurons;neuroproteomics;next generation;Organelles;Organism;Peptide Fragments;Peptide Library;Phosphatidylinositols;Post-Translational Protein Processing;Preparation;Property;protein biomarkers;Protein Phosphatase 2A Regulatory Subunit PR53;protein profiling;Proteins;Proteome;Proteomics;Protocols documentation;Puromycin;Rattus;Reaction;Research Personnel;Resolution;Resources;response;Running;Sampling;Source;Spinal;Subcellular Fractions;Synaptic Vesicles;Techniques;Technology;Tissues;Training;Transcript;translatome

PROJECT_TITLE: Targeted Proteomics Core


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Genetics;Immunization;Infectious Diseases;Lung;Prevention;Pulmonary Fibrosis;Vaccine Related

PHR: Project Narrative: We aim to elucidate the immunological basis of why otherwise healthy individuals develop severe COVID19 by studying the role of DPP9. Human genetics have highlighted the importance of DPP9 in response to SARS-CoV-2 infection, and our preliminary studies indicate this role is conserved in mice. We are therefore uniquely situated to determine how this susceptibility locus determines disease outcome to one of the biggest global health challenges in the last century.

PI_NAMEs: FLAVELL, RICHARD A (contact)

PROGRAM_OFFICER_NAME: ARNOLD, MICHELLE MARIE

PROJECT_TERMS: 2019-nCoV;adaptive immune response;Biological Assay;Cell Death;Cells;Cessation of life;comorbidity;coronavirus pandemic;COVID-19;COVID-19 risk;COVID-19 severity;COVID-19 susceptibility;cytokine;Data;Dendritic cell activation;Dendritic Cells;Development;Disease;Disease Outcome;Double-Stranded RNA;Effectiveness;Failure;Functional disorder;Future;Genes;Genetic;genetic regulatory protein;Genetic Transcription;genome wide association study;global health;Human;Human Genetics;Humoral Immunities;Hyperactivity;idiopathic pulmonary fibrosis;Immune;Immune response;Immunity;Immunologics;Individual;Inflammasome;Inflammatory;Investigation;K-18 conjugate;Knowledge;Lung;Mediating;migration;monocyte;mouse model;Mus;Myeloid Cells;novel;novel coronavirus;novel vaccines;Outcome;pathogen;Pathway interactions;Peptide Hydrolases;peripheral tolerance;pharmacologic;Phenotype;Physiology;Population;protein complex;Respiratory distress;respiratory virus;response;risk variant;Role;SARS-CoV-2 infection;sensor;severe COVID-19;Severity of illness;Stimulus;Susceptibility Gene;T cell response;T-Lymphocyte;Testing;ubiquitin-protein ligase;Vaccination;Vaccines;Viral;viral detection;Virus;Virus Inhibitors;Work

PROJECT_TITLE: Investigation of Dpp9 in COVID19

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IIDA-M(90)]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Data Science;Drug Abuse (NIDA only);Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Substance Misuse

PI_NAMEs: NAIRN, ANGUS C. (contact)

PROJECT_TERMS: Alleles;Autopsy;Benchmarking;Bioinformatics;Biological Assay;biomedical data science;Biometry;Biostatistics Core;Brain;Brain region;Catalogs;cell type;Cells;ChIP-seq;Cloud Computing;Collaborations;comparative;Complex;Computational Biology;computer framework;Computer software;crosslinking and immunoprecipitation sequencing;Data;Data Analyses;data imputation;data quality;Data Set;data visualization;database query;Databases;Detection;DNA Methylation;Doctor of Philosophy;Education;Elements;Environment;epigenomics;Event;Experimental Designs;Future;Genes;Genetic Transcription;genome sequencing;Genomics;graduate student;Grant;High Performance Computing;histone methylation;histone modification;Human;Individual;Joints;Label;large scale data;Medical Libraries;member;Messenger RNA;MicroRNAs;multidisciplinary;National Institute of Drug Abuse;neuroproteomics;novel;online resource;Peptides;Pilot Projects;Post-Translational Protein Processing;Postdoctoral Fellow;posttranscriptional;Privatization;programs;protein aminoacid sequence;Proteins;proteomic signature;Proteomics;Regulatory Element;Research;Research Design;Research Personnel;RNA;Sampling;Sequence Alignment;single-cell RNA sequencing;Small RNA;Source;Speed;Statistical Methods;Students;System;Tissues;tool;Training and Education;transcriptome sequencing;transcriptomics;Variant;Visualization;Visualization software;whole genome;Work

PROJECT_TITLE: Bioinformatics and Biostatistics Core


NIH_SPENDING_CATS: Brain Disorders;Drug Abuse (NIDA only);Neurosciences;Substance Misuse

PI_NAMEs: PICCIOTTO, MARINA R (contact)

PROJECT_TERMS: addiction;Applications Grants;Award;Biological;Brain;career;Cells;Conflict of Interest;Drug abuse;Drug Addiction;Electronic Mail;experience;Experimental Designs;Funding;Future;graduate student;Grant;improved;Institution;interest;Laboratories;Mentors;Mentorship;Methods;Mission;Modeling;Molecular;National Institute of Drug Abuse;Neurobiology;neuroproteomics;neurotransmission;new technology;novel;Peer Review;Pilot Projects;Positioning Attribute;Postdoctoral Fellow;Program Research Project Grants;programs;Proteomics;Publications;Qualifying;Research;Research Personnel;Research Project Grants;Resources;Role;Substance abuse problem;success;Suggestion;System;Technology;technology development;Training;Twitter;web site

PROJECT_TITLE: Pilot Research Projects Core


ORG_CITY: PHILADELPHIA

ORG_DEPT: NEUROSCIENCES

PHR: NARRATIVE Safe and effective strategies toward an HIV cure remain a clinically unmet challenge. This is due to HIV DNA integration in the host cell chromosome, where it remains in a latent state and persists in viral reservoirs. Upon cessation of ART, the virus reactivates and silent virus rebounds causing viremia and eventually progression toward AIDS. A highly effective, genetic strategy involving gene editing to excise viral DNA from the host together in concert with immune cell activation/improvement offers a promising curative strategy for the eradication of the virus.

PI_NAMEs: BURDO, TRICIA HELEN;KHALILI, KAMEL  (contact)

PROGRAM_OFFICER_NAME: POON, BETTY

PROJECT_TERMS: Ablation;Acceleration;Achievement;Acquired Immunodeficiency Syndrome;Address;Adenovirus Vector;Adenoviruses;Animal Model;antiretroviral therapy;B-Lymphocytes;Bar Codes;Basic Science;Binding;Biodistribution;bioinformatics pipeline;Biological Assay;Biological Response Modifier Therapy;Biotechnology;CCR5 gene;cell killing;Cell Maintenance;Cell Physiology;Cells;Chromosomes;Clinical;clinical investigation;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;collaboratory;Communities;community engagement;CRISPR therapeutics;CRISPR/Cas technology;cytokine;design;Development;Disease;Disease remission;DNA;DNA Integration;Education and Outreach;Effector Cell;Epigenetic Process;Excision;exhaustion;experience;FCGR3B gene;functional restoration;Funding Agency;Future;gene editing technology;gene-editing approach;Genes;genetic approach;Genetic Variation;Genome;genome editing;Genomics;Goals;Government;Granulocyte-Macrophage Colony-Stimulating Factor;Growth;Guide RNA;Hematopoietic stem cells;high throughput screening;Histopathology;HIV;HIV Infections;HIV-1;Human;humanized mouse;IL3 Gene;Immune;immune activation;Immune response;Immune system;Immunodeficient Mouse;Immunologics;implementation barriers;improved;in vivo;industry partner;Infection;innovation;innovative technologies;insight;Institution;Interleukin-15;Interleukin-6;Interruption;Knock-out;Knowledge;latent infection;latent virus activation;Lymphoid;Macaca;Macaca mulatta;Macrophage Colony-Stimulating Factor;manufacture;manufacturing capabilities;Measures;Mediating;Methods;Modification;Molecular;Monitor;Morbidity - disease rate;mortality;mouse model;Mouse Strains;multidisciplinary;Mus;Myelogenous;Myeloid Cells;Myelopoiesis;next generation;next generation sequencing;novel;novel strategies;operation;Outcome;Patients;Peripheral Blood Mononuclear Cell;Persons;Population;Positioning Attribute;pre-clinical;Private Sector;Probability;programmed cell death protein 1;programs;Proviruses;PTPNS1 gene;Research;Residual state;Resource Allocation;Resources;response;Role;Safety;Sampling;SIV;Specificity;Standardization;Structure;synergism;Technology;Testing;Thrombopoietin;Toxicology;transcriptomics;translational scientist;Up-Regulation;Viral;viral DNA;viral rebound;Viral reservoir;Viremia;Virus;virus genetics;Work

PROJECT_TITLE: CRISPR for Cure


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases;Prevention

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: Project Narrative The long-acting lipoglycopeptide dalbavancin can select for cross-resistance to vancomycin and daptomycin, which play critical roles in the management of invasive methicillin-resistant Staphylococcus aureus (MRSA) infections. This cross-resistance is highly correlated with the emergence of mutations in the walKR pathway but it remains unclear how WalKR dysfunction leads to resistance to each agent or whether this resistance can be mitigated. Our interdisciplinary team proposes to use integrated and complementary techniques to determine the mechanisms through which walKR mutations lead to dalbavancin, vancomycin, and daptomycin cross- resistance, and to use beta-lactams and other metabolic modulators to re-sensitize mutants and prevent resistance.

PI_NAMEs: WERTH, BRIAN JAMES (contact);XU, LIBIN

PROGRAM_OFFICER_NAME: HUNTLEY, CLAYTON C

PROJECT_TERMS: Affect;Alleles;Antimetabolites;antimicrobial;Bacteremia;beta-Lactams;Biochemical Pathway;biophysical analysis;Biophysics;cell envelope;Cell Wall;Clinical;Combined Modality Therapy;cost;Coupled;CRISPR interference;dalbavancin;Daptomycin;Dose;Drug Kinetics;drug preservation;Drug resistance;Drug Targeting;Endocarditis;Exhibits;experimental study;Exposure to;Folic Acid Antagonists;Fosfomycin;Frequencies;Functional disorder;Gene Expression;Genetic;genome sequencing;Glycopeptides;Goals;Grant;Half-Life;Hospitals;In Vitro;Individual;Infection;infection management;inhibitor;innovation;knock-down;Lead;lipid metabolism;lipidomics;Lipids;Mass Spectrum Analysis;Measures;Mediating;Metabolic;Metabolic Pathway;metabolic phenotype;Metabolism;metabolomics;Methicillin Resistance;methicillin resistant Staphylococcus aureus;Modification;mortality;mutant;Mutate;Mutation;nucleotide metabolism;Nucleotides;optimal treatments;Outcome;Outpatients;Parents;Pathway interactions;Patients;Pharmaceutical Preparations;pharmacodynamic model;Pharmacodynamics;pharmacokinetics and pharmacodynamics;Phenotype;Play;Predisposition;prevent;Prevention;Property;Proteomics;Publishing;Reporting;Resistance;resistant strain;response;Role;Serial Passage;standard care;Staphylococcus aureus;Staphylococcus aureus infection;Sulfamethoxazole;Superbug;synergism;System;targeted agent;Techniques;Testing;transcriptome sequencing;transcriptomics;treatment strategy;Trimethoprim;Vancomycin;Vancomycin Resistance;Walking;Water;Work

PROJECT_TITLE: Contribution of altered cell envelope metabolism to resistance to cell envelope-targeting antimicrobials in MRSA

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AIRT-J(01)]


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision

ORG_CITY: DAVIS

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Project Narrative This grant will provide support for high quality, specialized training in the mechanistic bases of vision and related diseases with modern approaches to the development of technologies and therapies for eye disease. In addition, this training program will broaden the research perspective, communication skills and knowledge base of future vision scientists. The program is designed to have significant impact on the health and science agendas of the National Eye Institute and to prepare the next generation of PhD scientists to enter the biomedical workforce.

PI_NAMEs: BURNS, MARIE E (contact)

PROGRAM_OFFICER_NAME: CLAYTON, EDWIN C

PROJECT_TERMS: Cornea;Training Programs;vision science

PROJECT_TITLE: Vision Science Training Program: Cornea to Cortex


ORG_CITY: CHICAGO

ORG_DEPT: NEUROLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: Giant Axonal Neuropathy is an autosomal recessive disease that results in early onset neurodegeneration. We have discovered that gigaxonin—the protein mutated in this disease—regulates the disassembly and degradation of cytoskeletal intermediate filaments. In this proposal we seek to elucidate the role of gigaxonin in neurons, in particular its part in modulating the levels of neuronal intermediate filaments along with identification of its other substrates, in order to understand the pathological basis of this disease and identify therapeutic targets.

PI_NAMEs: OPAL, PUNEET  (contact)

PROGRAM_OFFICER_NAME: NUCKOLLS, GLEN H

PROJECT_TERMS: Adaptor Signaling Protein;Adolescent;Alzheimer's Disease;Amino Acids;analog;Antisense Oligonucleotides;Autophagocytosis;Autophagosome;autosome;Axon;Axonal Transport;Behavioral;Cell Culture Techniques;Cell Nucleus;Cell Physiology;cell type;Cells;Central Nervous System;Clinic;Complex;Cytoskeleton;Data;Degradation Pathway;Disease;early onset;Endosomes;Environment;Event;Excision;experimental study;Family;forgetting;Functional disorder;Future;Genes;giant axonal neuropathy;gigaxonin;Goals;Impairment;Intermediate Filaments;Intracellular Transport;Knock-out;Knockout Mice;Light;loss of function mutation;Lysosomes;Mediating;member;Mitochondria;Modeling;Movement;multicatalytic endopeptidase complex;Mus;Mutate;Mutation;Names;Nerve Degeneration;Nervous System Disorder;Neurites;Neurodegenerative Disorders;neurofilament;Neurologic Symptoms;Neurons;neuropathology;neuroprotection;novel;Organelles;Parkinson Disease;Pathogenesis;Pathologic;Pathology;Pathway interactions;Peripheral Nervous System;Phenotype;Phosphorylation;Play;Process;protein degradation;Proteins;Proteomics;Quality Control;Regulation;Reporting;Research;Role;self assembly;Severities;Shapes;short hairpin RNA delivery;Signal Pathway;Signal Transduction;Sirolimus;Site;small molecule;Spinal Ganglia;Stable Isotope Labeling;Swelling;Testing;therapeutic target;therapy development;treatment strategy;Ubiquitin;ubiquitin ligase;ubiquitin-protein ligase;Ubiquitination

PROJECT_TITLE: Elucidating cellular mechanisms underlying neurodegeneration

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Kidney Disease;Neurosciences

PHR: Narrative: The brain controls the kidney's excretion of salt, its release of the blood pressure controlling protein, renin and its ability to remove blood poisons through filtration, and it is likely that disorders in brain control lead to hypertension and sudden failure of kidney function. Until we can identify the specific nerve cells in the brain which control the kidney, we will not be able make progress in understanding how the brain controls kidney function. The studies proposed in this grant will identify which nerve cells in two parts of the brain (hypothalamus and medulla) actually control kidney function and in doing so will open the way for investigators to map out the brain circuits that control kidney function in health and disease.

PI_NAMEs: STOCKER, SEAN D;ZEIDEL, MARK L. (contact)

PROGRAM_OFFICER_NAME: BRUNSKILL, ERIC WAYNE

PROJECT_TERMS: Acute Renal Failure with Renal Papillary Necrosis;Adrenergic Fibers;Affect;Atlases;Blood;Blood flow;Blood Pressure;blood pressure control;Brain;brain control;Brain region;Cell Nucleus;Cells;Chronic;Chronic Kidney Failure;CRH gene;Data;Disease;Electrolyte Balance;Electrolytes;Elements;Excretory function;experimental study;Filtration;FOXP2 gene;Future;Glomerular Filtration Rate;Glutamates;Goals;Grant;Health;Hypertension;Hypothalamic structure;In Situ;In Situ Hybridization;Injections;Kidney;Kidney Failure;kidney vascular structure;Label;Lateral;Lead;Link;mad itch virus;Maps;Methods;Mind;Mus;Nephrons;Nerve;Neural Pathways;neurochemistry;Neurons;novel;novel strategies;optogenetics;paraventricular nucleus;Phenotype;Play;Poison;Population;Proteins;Renal function;Renal Plasma Flow;Renin;Research Personnel;RNA;Role;salt balance;Sodium Chloride;Sorting;Spinal;Spinal Cord;Stress;Synapses;tool;Tracer;transcriptome sequencing;Transgenic Mice;Vascular resistance

PROJECT_TITLE: Autonomic control of kidney function

STUDY_SECTION: KUFD

STUDY_SECTION_NAME: Kidney and Urological Systems Function and Dysfunction Study Section[KUFD]


NIH_SPENDING_CATS: Bioengineering;Brain Disorders;Data Science;Epilepsy;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: This grant proposes to develop the capability for accurate, reliable seizure forecasting and adaptive brain stimulation using advances in machine learning. Focal canine epilepsy is an excellent model for investigation of seizure forecasting and adaptive brain stimulation because of the clinical and electrophysiological similarity to focal human epilepsy. This is an initial step in establishing a new treatment paradigm for focal epilepsy, whereby the probability of seizure occurrence is continuously tracked for patient warning and intelligent responsive adaptive brain stimulation or pharmacological therapies.

PI_NAMEs: WORRELL, GREGORY A (contact)

PROGRAM_OFFICER_NAME: CHURN, SEVERN BORDEN

PROJECT_TERMS: Anticonvulsants;Automobile Driving;Bilateral;Biological Markers;Body Temperature;Brain;Canis familiaris;Chronic;circadian;Classification;Clinical;convolutional neural network;Data Analytics;deep learning;Development;Device Designs;Devices;Dose;Drug Side Effects;Effectiveness;electric impedance;Electric Stimulation;Electrical Stimulation of the Brain;Electrocardiogram;Electroencephalography;Electrophysiology (science);Epilepsy;epileptiform;Event;Evoked Potentials;Focal Seizure;Goals;Grant;Hippocampus;Human;Immune Sera;Immunologic Factors;Immunologic Markers;Immunologics;Implant;implantable device;Implantable Injection/Infusion Ports;improved;Incidence;Individual;Injury;Investigation;learning strategy;Life;Machine Learning;machine learning method;machine learning model;Modeling;Morbidity - disease rate;multimodal data;multimodality;Neural Network Simulation;Partial Epilepsies;Patients;Pattern;Performance;Persons;pharmacologic;Physiological;prevent;Probability;prospective;psychologic;Psychological Impact;Research;response;Risk;Sampling;Seizures;Series;side effect;Signal Transduction;Stream;support vector machine;targeted treatment;Temperature;Temperature Sense;Therapy trial;Time;Work

PROJECT_TITLE: Reliable Seizure Prediction Using Physiological Signals and Machine Learning

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Nutrition;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: PROJECT NARRATIVE (limited to 2-3 sentences) Given the limited effectiveness of single food group-targeted interventions to enhance child nutrition, a key component of current and future health, innovative approaches are needed. Healthy dietary patterns are emerging as an important intervention target, and the Mediterranean Dietary pattern has been particularly effective at reducing cardiovascular disease risk factors, a leading cause of death in the US. Since parents are the gatekeepers of the home food environment and influence child intake through their food-related parenting practices, children enjoy cooking with their parents, and home food preparation is associated with more healthful dietary intake, we propose to develop and assess the feasibility, acceptability, and preliminary efficacy of an online cooking intervention for parent-child dyads living in low-income households that promotes the Mediterranean dietary pattern and healthful food-related parenting practices.

PI_NAMEs: THOMPSON, DEBORAH I (contact)

PROGRAM_OFFICER_NAME: BROWN, ALISON GWENDOLYN MARY

PROJECT_TERMS: 12 year old;acceptability and feasibility;Adolescence;Adopted;adopted child;Adult;American;anti-cancer research;Behavior;behavior change;behavior influence;Belief;cancer prevention;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;Cause of Death;Cellular Phone;Child;Child Behavior;Child Nutrition;Child Rearing;Childhood;Chronic Disease;Cognitive;cooking;cost;cultural values;Data Collection;design;Development;Diet;dietary;dietary guidelines;Dietary intake;Dietary Practices;digital intervention;disorder prevention;disorder risk;Early Intervention;Eating;Eating Behavior;Education;Educational Intervention;effective intervention;Effectiveness;efficacy testing;expectation;Family;family support;feeding;Food;food environment;food preparation;Fruit;Funding;Future;Gatekeeping;Health;health disparity;heart disease prevention;Home;Household;improved;Individual;innovation;insight;Intake;interest;Internet;Intervention;Learning;Low income;lower income families;Maintenance;Mediterranean Diet;Methods;Modeling;Modification;Motivation;nutrition;online intervention;Outcome;Parent-Child Relations;parenting intervention;Parents;Pattern;Play;Preparation;Preventive;Procedures;programs;prototype;Public Health;Qualitative Research;Recommendation;recruit;Reporting;Research;Risk;Risk Factors;Self Determination;Self Efficacy;skills;social;social interventions;Structure;success;Systems Theory;theories;trend;Waiting Lists

PROJECT_TITLE: Super Chef:  Family Fun in the Kitchen

STUDY_SECTION: SSPT

STUDY_SECTION_NAME: NHLBI Single-Site and Pilot Clinical Trials Study Section[SSPT(JA)]


NIH_SPENDING_CATS: Autoimmune Disease;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Multiple Sclerosis;Neurodegenerative;Neurosciences;Physical Activity;Physical Rehabilitation;Prevention;Rehabilitation

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

PHR: PROJECT NARRATIVE Multiple sclerosis (MS) is a common neurologic disease caused by inflammation and damage to myelin, the fatty substance that insulates nerve fibers. Myelin repair may be an effective strategy to improve mobility and prevent disability in people with MS and, in animal models of MS, aerobic exercise has been shown to repair myelin independently or synergistically with medications. This project will investigate how damage to myelin impacts mobility in people with MS and will help design a future, full-scale trial using aerobic exercise with myelin repair medications to overcome and prevent MS disability.

PI_NAMEs: WOOLISCROFT, LINDSEY BRIANNA (contact)

PROGRAM_OFFICER_NAME: BONNER, JOSEPH FRANCIS

PROJECT_TERMS: Action Potentials;Address;Aerobic;Aerobic Exercise;Affect;Animal Model;Axon;axon injury;axonal degeneration;Biological Markers;Body measure procedure;Clinical;clinical outcome measures;Clinical Trials;Clinical Trials Cooperative Group;Collaborations;Complement;Control Groups;Data;Demyelinations;design;Development;dexterity;disability;disability impact;Disability prevention;Disabling;Education;Electrophysiology (science);Enrollment;Ensure;Exercise;exercise adherence;exercise intervention;experience;Failure;falls;foot;Frequencies;Funding;Future;Gait abnormality;Goals;improved;improved mobility;Inflammation;Intervention;Lifelong disability;Lower Extremity;Measures;Mobility disability;Monitor;Multicenter Trials;multimodality;Multiple Sclerosis;multiple sclerosis patient;muscle strength;Myelin;myelination;Nerve Fibers;Nervous System Disorder;Neural Pathways;Neurologic;neurological rehabilitation;Neurons;neuroprotection;novel imaging technique;Outcome;Outcome Measure;Patient Outcomes Assessments;Patient Self-Report;Persons;Pharmaceutical Preparations;pharmacologic;Pharmacotherapy;prevent;primary outcome;Randomized;randomized, clinical trials;Recurrence;Rehabilitation therapy;remyelination;repaired;Reproducibility;Research;Research Design;safety and feasibility;Sample Size;Single-Blind Study;Somatosensory Evoked Potentials;Spinal Cord;Spinal Remyelination;Structure;Supervision;Symptoms;Testing;Therapeutic;Time;Upper Extremity;Walking;walking speed;Work;young adult

PROJECT_TITLE: Aerobic exercise to improve mobility in multiple sclerosis: optimizing design and execution for a full-scale multimodal remyelination clinical trial

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Function, Integration, and Rehabilitation Sciences Study Section[CHHD-K]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cannabinoid Research;Drug Abuse (NIDA only);Natural Products;Neurosciences;Substance Misuse

ORG_CITY: PITTSBURGH

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative Polysubstance use is a very common phenomenon that is generally thought to lead to worse outcomes than use of single substances. However, very little preclinical research has investigated polysubstance use, leading to a gap in our fundamental knowledge of how combinations of drugs may produce differential outcomes relative to single drug exposure. Thus, this project will use an established model of co-use of nicotine and THC, two of the most commonly co-used substances, to investigate neural mechanisms by which the two drugs interact to produce changes in dopamine neuron function and enhanced THC reinforcement.

PI_NAMEs: TORREGROSSA, MARY M (contact)

PROGRAM_OFFICER_NAME: NAIR, SUNILA GOPI

PROJECT_TERMS: Acute;addiction;Address;Adoption;Affect;Alcohols;Animal Model;Animals;antagonist;Area;Biotinylation;Brain;cannabinoid receptor;Cannabis;Catheters;cell type;Choices and Control;Clinical;Cognitive;Color;comparison group;Consumption;Control Groups;design;Dopamine;dopaminergic neuron;Drug Combinations;Drug Exposure;Drug Interactions;drug of abuse;Drug user;epidemiologic data;epidemiology study;experimental study;Fiber;functional outcomes;gamma-Aminobutyric Acid;General Population;Glutamates;Implant;Incidence;Individual;insight;Intake;Intravenous;Intravenous infusion procedures;Investigation;Knowledge;Label;Left;Marijuana;marijuana use;marijuana user;Mass Spectrum Analysis;Measures;Mediating;Methods;Modeling;Motivation;National Institute of Drug Abuse;neural;neurobiological mechanism;neuromechanism;Neuronal Plasticity;Neurons;Nicotine;nicotine use;Nicotinic Receptors;novel;Nucleus Accumbens;Outcome;Pharmaceutical Preparations;phosphoproteomics;Phosphorylation;Photometry;polysubstance use;pre-clinical;pre-clinical research;preference;Prevalence;Procedures;Property;Proteins;Proteomics;Psychological reinforcement;Public Health;Rattus;receptor;Relapse;Reporting;Research;response;Rewards;Role;Saline;Self Administration;Signal Transduction;Signaling Protein;social;Speed;Structure of jugular vein;substance use;substance use treatment;System;Testing;Tetrahydrocannabinol;Time;tobacco smokers;transmission process;Tyrosine 3-Monooxygenase;Ventral Tegmental Area;Viral

PROJECT_TITLE: Investigating mechanisms mediating enhanced THC reinforcement by nicotine