ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative  Multidrug-resistant Pseudomonas aeruginosa infections are a critical public health threat and a desired target for bacteriophage therapy. Nucleus-forming bacteriophages are a recently discovered class of bacteriophage with high therapeutic potential due to their lytic nature and intrinsic resistance to multiple bacteriophage defense systems. The research in this proposal will determine the genetic, biochemical, and structural basis for protein import into the phage nucleus, as well as how these bacteriophages affect pathogenicity and antibiotic sensitivity in P. aeruginosa.

PI_NAMEs: MORGAN, CHASE  (contact)

PROGRAM_OFFICER_NAME: XU, ZUOYU

PROJECT_TERMS: Affect;antibiotic tolerance;Antibiotics;antimicrobial resistant infection;Aorta;Bacteria;Bacteriophages;Biochemical;Carrier Proteins;Cell Nucleus;Cells;Clinical;co-infection;Complex;cost;Cryoelectron Microscopy;Cytoplasmic Protein;Data;Defect;design;Development;Disparate;DNA;DNA Restriction Enzymes;DNA-Directed DNA Polymerase;DNA-Directed RNA Polymerase;efflux pump;Electron Microscopy;Encapsulated;endonuclease;Engineering;Enzymes;Essential Genes;Exclusion;Genetic;genetic selection;Genome;genome editing;Goals;Homologous Gene;Homologous Protein;Human;In Situ;In Vitro;Infection;interest;Label;Life;Light;Lytic;Mediating;Membrane;Multi-Drug Resistance;multidrug-resistant Pseudomonas aeruginosa;Mus;mutant;Mutation;Nature;Nuclear;Nuclear Localization Signal;Nuclear Proteins;Nucleotides;particle;pathogenic microbe;Pathogenicity;Pattern;Play;pneumonia model;Population;Property;Protein Import;protein transport;Proteins;Pseudomonas;Pseudomonas aeruginosa;Pseudomonas aeruginosa infection;Public Health;Research;Resistance;resistant strain;Role;Signal Transduction;Signaling Protein;Structure;Surface Antigens;System;Testing;Therapeutic;thymidylate kinase;Time;trait;Variant

PROJECT_TITLE: Investigating the mechanism of infection and therapeutic potential of Pseudomonas nucleus-forming phages

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F07A-B (20)]


ADMINISTERING_IC: CA

ARRA_FUNDED: N

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Genetics

ORG_CITY: SILVERTHORNE

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: KEYSTONE SYMPOSIA

ORG_STATE: CO

PHR: PROJECT NARRATIVE Epigenetic mechanisms govern how behavior and environment affect the way genes work and thus, have direct influences in regulating cellular and organismal health. When epigenetic processes go awry serious health problems, including cancer, can result and lead to mortallity. This conference will bring together biological researchers, who understand the fundamental principles of epigenetic deregulation in cancer, with scientists from industry who are skilled at advancing drug discovery and development, to discuss frontiers in the field and translating these discoveries for improving human health.

PI_NAMEs: SHEPPARD, TERRY L. (contact)

PROGRAM_OFFICER_NAME: SHARMAN, ANU

PROJECT_TERMS: Academia;Affect;Basic Science;Behavior;Biological;Biotechnology;Cancer Patient;cancer therapy;career;Career Choice;Clinic;Clinical;clinical practice;Collaborations;Development;Diet;Disease;drug development;drug discovery;Educational workshop;Environment;Epigenetic Process;experience;forging;frontier;fundamental research;Future;Genes;Health;Human;improved;Industrialization;Industry;industry partner;interest;Knowledge;Learning;Malignant Neoplasms;Mentors;Methodology;Mutation;Neoplasm Metastasis;New Mexico;new technology;next generation;novel strategies;Outcome;Pathway interactions;Patients;Pharmacologic Substance;posters;Predisposition;prevent;programs;Reporting;Research;Research Personnel;Resistance;Role;Science;Scientist;Senior Scientist;Side;skills;symposium;therapy outcome;Thinking;Training;Translating;Translations;tumor;Woman;Work

PROJECT_TITLE: Epigenetic Mechanisms and the Treatment of Cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 PCRB-9 (O1)]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE Antimicrobial resistance is an urgent and growing threat, with a projected toll of 10 million deaths annually by 2050. A firmer understanding of existing antibiotics’ mechanisms of action and avoidance of resistance would make critical steps towards combating this public health crisis. By developing insight into the mechanism of oxazolidinone activity and the ability of certain compounds in the class to avoid emerging mechanisms of resistance, this proposal will greatly expand understanding of context-specific antibiotics and inform development of therapeutics with enhanced efficacy.

PI_NAMEs: KLEINMAN, JORDAN ISABELLE (contact)

PROJECT_TERMS: Affect;Alanine;analog;Anti-Bacterial Agents;Antibiotic Resistance;Antibiotics;antimicrobial;Antimicrobial Resistance;Bacterial Infections;bacterial resistance;Binding;Biological Assay;Cessation of life;Clinical;Collaborations;Complex;Cryoelectron Microscopy;Data;Development;effective therapy;Exhibits;FDA approved;Genes;improved;In Vitro;Infection;infectious disease treatment;Infectious Skin Diseases;inhibitor;insight;Investigation;Knowledge;Libraries;Linezolid;Link;Literature;Mediating;Methylation;Mission;Modeling;Modification;Molecular;Multi-Drug Resistance;National Institute of Allergy and Infectious Disease;Natural Products;Oxazolidinones;Parents;pathogen;Peptides;Pharmaceutical Preparations;Play;Positioning Attribute;Predisposition;preference;Proteins;Public Health;rational design;Research;Resistance;resistance factors;resistance frequency;resistance mechanism;Ribosomal RNA;ribosome profiling;Ribosomes;Role;Specificity;Structure;Structure-Activity Relationship;therapeutic development;tool;Translational Repression;Translations;Treatment Efficacy;Variant;Work

PROJECT_TITLE: Elucidating the role of context-specificity in oxazolidinone mechanism of action


ADMINISTERING_IC: AG

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Data Science;Dementia;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Prevention

ORG_CITY: Los Angeles

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: NARRATIVE Artificial intelligence and deep learning methods have been highly successful in detecting Alzheimer’s disease (AD) and discovering patterns in brain MRI and PET scans associated with dementia. We launch a global alliance of AD experts and Artificial Intelligence (AI) teams worldwide to create a Secure Federated Learning framework, learning from diverse international data. Our novel AI approach computes, without sharing data, on multiple geographically distributed AD biobanks - in India, Japan, the U.S. and Europe - to diagnose and subtype dementia, to infer brain amyloid and tau burden from less invasive biomarkers, and predict who will decline clinically from health or mild cognitive impairment to AD, facilitating clinical trial selection and personalized prognosis.

PI_NAMEs: AMBITE, JOSE LUIS;THOMPSON, PAUL M (contact)

PROGRAM_OFFICER_NAME: YAO, ALISON Q

PROJECT_TERMS: abeta deposition;Acceleration;Accounting;Address;age related neurodegeneration;Alzheimer disease detection;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease related dementia;Alzheimer's disease risk;Amyloid;Architecture;Artificial Intelligence;artificial intelligence method;artificial intelligence model;Artificial Intelligence platform;autoencoder;Benchmarking;Binding;biobank;biobehavior;Biological;Biological Markers;blood-based biomarker;Brain;brain magnetic resonance imaging;Classification;Clinical;Clinical Data;Clinical dementia rating scale;Clinical Trials;Cognitive;cognitive ability;cohort;Complex;cost;Data;data harmonization;Data Set;data sharing;deep learning;deep learning model;deep neural network;Dementia;Diagnosis;Disease;disease prognosis;Disease Progression;Distributed Systems;drug discovery;Early Diagnosis;East Asian;empowerment;encryption;Ensure;Environment;Episodic memory;Europe;experience;Extravasation;federated learning;follow-up;Funding;Future;Genetic;Genome;genomic data;Genomics;Geography;Health;Image;India;Individual;innovation;insight;Institutional Review Boards;International;Japan;Japanese;large datasets;Learning;Machine Learning;Magnetic Resonance Imaging;Malignant Breast Neoplasm;Malignant neoplasm of prostate;Measures;Memory;Meta-Analysis;Methodology;Methods;mild cognitive impairment;Modeling;MRI Scans;multimodality;multiple data types;neural;neuroimaging;Neuropsychology;novel;novel strategies;Onset of illness;Outcome;Participant;Pathogenicity;patient privacy;Pattern;Performance;Persons;Phenotype;phenotypic data;Population;Positron-Emission Tomography;predictive modeling;Predisposition;preservation;prevent;Prevention;Privacy;Privatization;Process;Productivity;Prognosis;prognostic;repository;Research;Research Personnel;Running;Sampling;Sampling Studies;Secure;Security;Site;Social Network;South Asian;Spain;Staging;Standardization;success;Sum;tau Proteins;tau-1;Techniques;Testing;Training;training data;Weight;Work

PROJECT_TITLE: Federated Deep Learning to Accelerate Alzheimer's Disease Research

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 HSS-Z (90)]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology

ORG_DEPT: OPHTHALMOLOGY

PHR: PROJECT NARRATIVE  Dysfunction of the primary cilium causes obesity, skeletal abnormalities, kidney cysts and retinal degeneration. The proposal aims to uncover the basic principles that underlie the packaging of ciliary signaling receptors into extracellular vesicles. If successful, this research program will further our understanding of retinal degeneration and obesity and provide novel means for therapeutic intervention.

PI_NAMEs: NACHURY, MAXENCE V (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TERMS: Actins;Back;Biological Assay;Cell Compartmentation;Cells;Cilia;ciliopathy;Coupled;CRISPR screen;Cues;Cystic kidney;Data;Dedications;design;Development;Devices;Disease;Engineering;Erinaceidae;extracellular vesicles;Functional disorder;Future;G-Protein-Coupled Receptors;Goals;Hair;hepatocyte growth factor-regulated tyrosine kinase substrate;insight;Knowledge;Ligase;Link;luminescence;Membrane;miniaturize;Modality;Modeling;Molecular;Movement;Mus;mutant;novel;Obesity;Pathway interactions;Phenotype;Phosphotransferases;Physiological;programs;Proteins;Proteome;Proteomics;Quality Control;Reader;Receptor Signaling;Regulation;Research;Rest;Retinal Degeneration;Retrieval;Role;Route;sensory input;Shapes;Signal Pathway;Signal Transduction;skeletal abnormality;Smell Perception;smoothened signaling pathway;Specific qualifier value;Specificity;Symptoms;Testing;Therapeutic Intervention;tool;Transducers;Ubiquitin;Vision;Work

PROJECT_TITLE: Quality Control of the cilia proteome

STUDY_SECTION_NAME: Cell Structure and Function 1 Study Section[CSF1]


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

PHR: PROJECT NARRATIVE Drug discovery is undergoing a revolution that is now using molecules to induce “closeness” of cellular molecules as a new approach to developing therapeutics. “Proximity-based therapeutics” have the potential to regulate biological targets in a new way that will allow the development of drugs for diseases thought to have previously been “undruggable”. This conference program will bring together interdisciplinary groups of scientists, including biologists and chemists, from both academic and industry to explore the latest findings in this field and accelerate its growth.

PROGRAM_OFFICER_NAME: SHARMA, KARLIE ROXANNE

PROJECT_TITLE: Proximity Based Therapeutics

STUDY_SECTION_NAME: Special Emphasis Panel[ZTR1 CG-4 (02)]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Ataxia Telangiectasia;Genetics;Neurodegenerative;Primary Immunodeficiencies;Rare Diseases

ORG_CITY: EAST LANSING

ORG_DEPT: PATHOLOGY

ORG_NAME: MICHIGAN STATE UNIVERSITY

ORG_STATE: MI

PHR: Project Narrative B and T lymphocytes utilize special receptors to recognize pathogens called antibodies and T cell receptors; genes encoding these receptors do not exist in our genome as functional genes, but are assembled from small gene segments during lymphocyte development by a process called VDJ recombination. However, since this process requires breaking and repairing DNA, mistakes can occur that sometimes result in deleterious genome alterations, which have been shown to promote the development of lymphoid cancers. This application aims to elucidate how VDJ recombination is regulated so that these potentially cancer causing mistakes do not occur.

PI_NAMEs: MEEK, KATHERYN D (contact);YU, KEFEI

PROGRAM_OFFICER_NAME: CASTLEMAN, MORIAH JOVITA

PROJECT_TERMS: Ablation;access restrictions;adaptive immune response;Affect;Alanine;Antibodies;Antigen Receptors;Ataxia Telangiectasia;ataxia telangiectasia mutated protein;Ataxia Telangiectasia Patients;ATM deficient;Atrophic;Biochemical;Biological Assay;Cancer Etiology;Cell Line;Cell model;Cells;Cellular Assay;Code;Complex;Cultured Cells;Data;Defect;Development;Disease;DNA Damage;DNA Double Strand Break;DNA Repair;DNA Repair Pathway;DNA-dependent protein kinase;endonuclease;Exons;experimental study;Gene Pool;Genes;Genetic Recombination;Genome;Genomic Instability;Genomics;Growth;Human;Immune System Diseases;immunodeficiency;In Vitro;in vivo;Infertility;Lymphocyte;lymphoid neoplasm;Malignant lymphoid neoplasm;Modeling;Mus;mutant;Nonhomologous DNA End Joining;Occupations;pathogen;Pathway interactions;Phenotype;Phosphorylation;Phosphorylation Site;Phosphotransferases;Predisposition;Premature aging syndrome;prevent;Process;RAG1 gene;receptor;repaired;Research;Resistance;Resolution;response;restraint;Role;Signal Transduction;Site;Structure;T-Cell Receptor;T-Lymphocyte;Telangiectasis;V(D)J Recombination;virtual

PROJECT_TITLE: Defining the mechanistic basis of ATM’s impact on VDJ recombination

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IMM-T(02)]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Brain Disorders;Depression;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences

ORG_CITY: Nashville

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: PROJECT NARRATIVE The objective of this grant is to study the role of BDNF in the hippocampus in regulating homeostatic synaptic plasticity critical for mediating antidepressant responses in mice. Based on our preliminary data presented in this application, we will examine the impact of BDNF specifically in the hippocampus on homeostatic synaptic scaling in vivo in rapid antidepressant responses. These studies will use molecular, cellular, behavioral, and electrophysiological approaches to investigate whether BDNF is sufficient to drive synaptic scaling in vivo and mediate fast-acting antidepressant responses, in the hopes of developing novel antidepressants with rapid onset of clinical efficacy.

PI_NAMEs: MONTEGGIA, LISA M (contact)

PROGRAM_OFFICER_NAME: DRISCOLL, JAMIE DANIELLE

PROJECT_TERMS: Acids;Acute;Affect;Affinity;AMPA Receptors;Animals;antagonist;anti-depressive agents;antidepressant effect;Attenuated;Behavior;Behavioral;Brain;Brain-Derived Neurotrophic Factor;C57BL/6 Mouse;calmodulin-dependent protein kinase III;channel blockers;Chemosensitization;Chronic;Clinical;clinical efficacy;Data;Depressed mood;Development;Electrophysiology (science);Excitatory Postsynaptic Potentials;Funding;Genetic Polymorphism;Glutamates;Grant;Hippocampus;In Vitro;in vivo;Infusion procedures;insight;Ketamine;kinase inhibitor;Knockout Mice;Link;Mediating;Mediator;Mental Depression;Molecular;Mus;N-Methyl-D-Aspartate Receptors;N-Methylaspartate;Neuronal Plasticity;Neurons;neurotransmission;neurotrophic factor;Neurotrophic Tyrosine Kinase Receptor Type 2;novel;Patients;Peptide Elongation Factor 2;Phosphorylation;Postsynaptic Membrane;Pre-Clinical Model;Predisposition;Property;Prosencephalon;Protein Dephosphorylation;Proteins;receptor;Receptor Activation;Regulation;Research;response;Rest;Role;sensor;Signal Transduction;Synapses;synaptic function;Synaptic plasticity;Synaptic Transmission;Testing;Transcript;Translational Derepression;Translations;treatment-resistant depression;Wild Type Mouse;Work

PROJECT_TITLE: Antidepressants and Intracellular Signaling Linked to BDNF

STUDY_SECTION: MNPS

STUDY_SECTION_NAME: Molecular Neuropharmacology and Signaling Study Section[MNPS]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: Columbus

ORG_DEPT: PHYSIOLOGY

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: NARRATIVE Fibrosis in the heart is bad and contributes to poor survival for patients with heart failure, which afflicts millions of Americans, yet no effective treatments for fibrosis in the heart are available. Using special (genetically modified) mice, the proposed study will determine if targeting a specific protein, BRD4, in fibroblasts might work as a treatment for fibrosis in the heart and will determine if other proteins in the same family are important for turning on and off specific genes in the heart. Together, this work will help us understand how cells in the heart become disease activated and help us progress toward finding better treatments for heart failure.

PI_NAMEs: FRANCOIS, ASHLEY  (contact)

PROGRAM_OFFICER_NAME: HUANG, LI-SHIN

PROJECT_TERMS: Adult;adverse outcome;Agonist;American;Angiotensin II;Antibodies;Apoptosis;Architecture;Binding;Biological Assay;BRD2 gene;Bromodomain;Bromodomains and extra-terminal domain inhibitor;Cardiac;Cardiac Myocytes;Caspase;Cell Culture Techniques;cell type;Cells;Cessation of life;Chemicals;ChIP-seq;Chromatin;chromatin protein;Chronic;Clinical;coronary fibrosis;Coupled;Deposition;Disease;Disease Progression;DNA Polymerase II;Echocardiography;effective therapy;Electric Conductivity;Enhancers;Epigenetic Process;epigenetic regulation;experimental study;Extracellular Matrix;Extracellular Matrix Proteins;Family;Family member;Fibroblasts;Fibrosis;Functional disorder;Gene Expression;Gene Expression Regulation;Gene Modified;Genes;Genetic;Genetic Transcription;Genome;Goals;Heart;Heart failure;heart function;Heart Hypertrophy;heart preservation;hemodynamics;Histology;Histone Acetylation;Homeostasis;Hypertrophy;Immunoprecipitation;Impairment;improved;in vivo;in vivo evaluation;Individual;Inflammation;Infusion procedures;inhibitor;Injury;insight;Investigation;Laboratories;Left ventricular structure;Lysine;Measures;Mediating;Methods;mimetics;Mitochondria;mouse model;Mus;Muscle Cells;Myocardial dysfunction;Myofibroblast;Norepinephrine;Pathologic;Pathology;Patient-Focused Outcomes;Patients;Pharmacology;Phenylephrine;Physiology;Prevention;Process;programs;Proliferating;promoter;Protein Family;Proteins;Rattus;Reader;Relaxation;response;RNA;Rodent Model;Role;small molecule;small molecule inhibitor;Stimulus;Stress;Supervision;Tamoxifen;targeted treatment;Tertiary Protein Structure;Testing;therapeutically effective;Tissues;Ventricular;Work;wound healing;wound response

PROJECT_TITLE: The role of BET proteins in pathological cardiac remodeling


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Genetics;Muscular Dystrophy;Myotonic Dystrophy;Neurosciences;Rare Diseases

ORG_CITY: ATLANTA

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: The proposed basic research is focused on better understanding how RNAs are localized and translated in neurons. Perturbations to these processes occur in many neurological diseases, but we do not have a good understanding of how RNA localization occurs. This research has implications for many neurological diseases.

PI_NAMEs: BASSELL, GARY J (contact);WANG, ERIC T

PROGRAM_OFFICER_NAME: NUCKOLLS, GLEN H

PROJECT_TERMS: Adult;Alternative Splicing;Axon;Basic Science;Biochemical;biophysical properties;Brain Diseases;Cell Nucleus;Cell Physiology;Cells;Cellular biology;Charcot-Marie-Tooth Disease;Complex;CUG repeat;Cytoplasm;Cytoplasmic Granules;Cytoskeleton;Dendrites;Destinations;Development;Disease;Distal;Elements;Exhibits;FMR1 gene;Fragile X Syndrome;Genomics;Hippocampus;Impairment;In Vitro;Investigation;Kinesin;Kinetics;Link;live cell imaging;Maintenance;Mediating;Membrane;Messenger RNA;Microtubules;Mitochondria;Modeling;Morphology;Motility;Motor;mouse model;Mus;Muscle;Mutate;Myotonic Dystrophy;Nerve Degeneration;Nervous System Disorder;Neurites;Neurologic;neuron development;Neurons;Neuropil;novel;Pathogenesis;Patients;postsynaptic;Process;Property;Proteins;proteostasis;Records;Regulation;Reporting;Research;Resolution;RNA;RNA Splicing;RNA Transport;RNA-Binding Proteins;Signal Transduction;Site;Skeletal Muscle;Symptoms;Synapses;synaptic function;Synaptic plasticity;Synaptic Vesicles;Translating;Translations;Variant;vesicular release

PROJECT_TITLE: Mechanism and Function Of MBNL Mediated mRNA Localization in Neuronal Development and Neurologic Disease

STUDY_SECTION: SYN

STUDY_SECTION_NAME: Synapses, Cytoskeleton and Trafficking Study Section[SYN]


NIH_SPENDING_CATS: Genetics;Neurosciences

PHR: Project Narrative: Relevance to Public Health A number of human diseases result from mutations in genes that play broad roles in all cell types in our bodies, but the clinical consequences are restricted to only some cell types, tissues or organs. This type of scenario occurs very regularly where the brain and the cells, termed neurons, that are key for proper brain function are affected. The proposed studies use a combination of model systems to explore the molecular basis for a specific form of neurodevelopmental human disease, a heritable form of intellectual disability, by exploring the intersection of specific factors and modifications of RNA that may help to explain why neurons are impacted and define a paradigm for such diseases.

PI_NAMEs: CORBETT, ANITA H.;MOBERG, KENNETH H (contact)

PROGRAM_OFFICER_NAME: RIDDLE, ROBERT D

PROJECT_TERMS: activation-induced cytidine deaminase;Affect;axon guidance;Behavioral;Binding;Binding Proteins;Binding Sites;Biological Assay;Biological Models;Brain;Cell Line;cell type;Cells;Central Nervous System;Cis-Acting Sequence;Clinical;Consensus;Coupled;Data;Defect;Dendritic Spines;Deposition;Development;Disease;Drosophila genus;Drosophila melanogaster;Elements;Event;exon skipping;Exons;Experimental Genetics;Female;fly;Foundations;Genes;Genetic;Genetic Models;Heritability;Homologous Gene;Human;human disease;Hypermethylation;in vivo;in vivo evaluation;Individual;Inherited;inhibitor;insight;Intellectual functioning disability;Introns;Link;Locomotion;Maps;Mediating;Memory;Messenger RNA;model organism;Modeling;Modification;Molecular;Molecular Probes;Morphogenesis;Morphology;mRNA Precursor;Mus;Mutation;Nervous System;neurodevelopment;Neurodevelopmental Disorder;Neuronal Differentiation;Neurons;novel;Nuclear;Organ;Orthologous Gene;Pathway interactions;Phenotype;Play;Poly(A)+ RNA;polyadenosine;Post-Transcriptional Regulation;protein function;Proteins;Public Health;Publishing;Reader;recruit;Regulation;Reporter;RNA;RNA Splicing;RNA-Binding Proteins;Role;sex;sex determination;Site;Specific qualifier value;Testing;Tissues;tool;Trans-Activators;Transcript;transcriptome;Translations;unpublished works;Vertebrates;Work;Zinc Fingers

PROJECT_TITLE: A Conserved RNA Binding Protein Required for Control of Key Developmental Pathways

STUDY_SECTION: NCF

STUDY_SECTION_NAME: Neurogenesis and Cell Fate Study Section[NCF]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Cancer Genomics;Colorectal Cancer;Digestive Diseases;Genetics;Human Genome;Women's Health Research

ORG_CITY: BLACKSBURG

ORG_DEPT: BIOLOGY

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

ORG_STATE: VA

PHR: Project Narrative Given the prevalence of nuclear size alterations and whole genome doubling (WGD) in malignant tumors, the aim of this proposal is to determine how variations in nuclear size after WGD affect tumorigenic potential and identify the cellular mechanisms that regulate nuclear size in tetraploid (4N) cells. These findings will yield new insights into the epigenetic and transcriptional consequences of WGD and unveil whether nuclear size is important for 4N cell tumorigenicity. Leveraging the mechanisms that link nuclear size, increased ploidy, and tumorigenicity may refine current cancer diagnostic practices and lead to the development of new strategies that target nuclear size in cancer cells for therapeutic benefit.

PI_NAMEs: BLOOMFIELD, MATHEW  (contact)

PROGRAM_OFFICER_NAME: SCHMIDT, MICHAEL K

PROJECT_TERMS: Address;Affect;Agar;Anchorage-Independent Growth;Aneuploidy;Animal Model;Animals;behavior in vitro;Bioinformatics;Biological Assay;Biopsy;Breast;Breast Cancer Cell;Breast Cancer cell line;Breast Epithelial Cells;cancer cell;Cancer cell line;Cancer Diagnostics;career;Cell Culture Techniques;Cell Line;Cell Nucleus;Cell Size;cell type;Cells;Cessation of life;Chemicals;Clinical;Clinical Data;Clone Cells;Colon;Colon Carcinoma;Colorectal Cancer;Computer Analysis;Cytokinesis;Cytoplasm;Data;Development;digital;Diploidy;Disease;DNA Methylation;Environment;Epigenetic Process;epigenomics;Event;Experimental Models;experimental study;Failure;fitness;Gene Expression;Gene Expression Profiling;Genes;Genetic;Genetic Transcription;Genome;genomic data;Genomics;HCT116 Cells;Histones;Histopathology;Human;Image;in silico;In Vitro;in vivo;insight;Institution;Interdisciplinary Study;interest;Invaded;Link;Malignant Neoplasms;Mass Spectrum Analysis;Measures;Metabolic;Metabolism;Metastatic breast cancer;Methods;Mitotic;Modeling;Mus;Nature;neoplastic cell;novel;Nuclear;Phenotype;Ploidies;Population;Post-Translational Protein Processing;Postdoctoral Fellow;Prevalence;Process;Regulation;Research;Research Personnel;Research Project Grants;Resources;Running;Scientist;Shapes;Soft tissue sarcoma;success;Technical Expertise;Testing;Tetraploidy;The Cancer Genome Atlas;Therapeutic;therapeutic target;Training;training opportunity;Training Programs;tumor;tumor progression;tumor xenograft;tumorigenesis;tumorigenic;Tumorigenicity;United States;Variant;whole genome;Work;Xenograft procedure

PROJECT_TITLE: Understanding how variations in nuclear size after whole genome doubling affect tumorigenesis


ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Certain adjuvants lead to allergic sensitization, but their mechanisms of action are poorly understood. We discovered that a subset of non-steroidal anti-inflammatory drugs (NSAIDs) are sufficient as allergic adjuvants. We propose to mechanistically dissect how NSAIDs act as adjuvants to cause allergic sensitization.

PI_NAMEs: WANG, ANDREW  (contact)

PROGRAM_OFFICER_NAME: MINNICOZZI, MICHAEL

PROJECT_TERMS: Acetaminophen;adduct;Adjuvant;Affect;Allergic;Allergic Disease;allergic response;American;Analgesic and Antipyretic;Analgesics;Antigen Presentation;Antigens;Cell Nucleus;Cells;Chemical Structure;Chemicals;Child;Cholera Toxin;Collaborations;Cysteine;Data;Dendritic Cells;Development;Dissection;dosage;Dose;drug action;Drug usage;Environment;Environmental Exposure;Epithelial Cells;Erythroid;Etiology;Exposure to;Fatty acid glycerol esters;Food;food antigen;food consumption;Food Hypersensitivity;Food Preservatives;Genetic;gut microbiome;Health Policy;High Prevalence;Human;Hydroquinones;Hypersensitivity;Ibuprofen;Immune response;Incidence;Ingestion;intestinal epithelium;Intestines;Knock-out;Lead;Link;man;Mediating;Medicine;microbiota;microbiota composition;Modeling;Modernization;Mus;Non-Steroidal Anti-Inflammatory Agents;novel;novel therapeutics;Nuclear;nuclear factor-erythroid 2;Oral;oral tolerance;Ovalbumin;Pathway interactions;Persons;Pharmaceutical Preparations;pharmacologic;Predisposition;Prevalence;Process;Production;Property;PTGS2 gene;Public Health;receptor;Role;sensor;Severities;Signal Transduction;Source;Specificity;Testing;Time;urban setting;Work;Xenobiotics

PROJECT_TITLE: Dissecting How Xenobiotics Act as Adjuvants for Oral Allergic Sensitization

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIB-E(57)]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Colistin is an antibiotic that is reserved for the treatment of serious infections caused by bacteria that are resistant to other antibiotics but increasing use of colistin has led to the emergence of colistin-resistant strains of bacteria. There is also significant concern that colistin may not be working as well in patients with infection as it may be in test tubes. This project will expand our ongoing investigation on how bacteria can become resistant to colistin and develop rapid and accurate methods to detect resistance.

PI_NAMEs: DOI, YOHEI  (contact);ERNST, ROBERT K

PROGRAM_OFFICER_NAME: HUNTLEY, CLAYTON C

PROJECT_TERMS: Acinetobacter baumannii;acronyms;Address;Adjuvant;Antibiotics;appropriate dose;Bacteria;Bacterial Pneumonia;bacterial resistance;Basic Science;Biological Assay;Bronchoalveolar Lavage;Bronchoalveolar Lavage Fluid;Chemicals;Clinical;Clinical Microbiology;Clinical Research;clinically relevant;Colistin;colistin resistance;Detection;Dose;Drug Kinetics;Enterobacter;ESKAPE pathogens;experimental study;extensive drug resistance;Failure;Funding;Galactosamine;Glycolipids;Gram-Negative Bacteria;Hospitals;Human;improved;In Vitro;in vitro activity;in vivo;Infection;insight;Interdisciplinary Study;Investigation;Klebsiella pneumoniae;Knowledge;Laboratories;Lipid A;Lipids;Lipopolysaccharides;liquid chromatography mass spectrometry;Lung infections;Mediating;Membrane;Methods;Modeling;Modification;Morbidity - disease rate;mortality;Mus;Mutation;novel;Outcome;pathogen;Patients;phosphoethanolamine;Pneumonia;Polymyxins;predictive test;Predisposition;pressure;prospective;Protocols documentation;Pseudomonas aeruginosa;public health priorities;Resistance;resistance mechanism;resistant strain;Series;side effect;Site;small molecule;Specimen;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;Structure of parenchyma of lung;Synthesis Chemistry;System;Testing;Tube;ventilator-associated pneumonia

PROJECT_TITLE: Colistin resistance in extensively drug-resistant Gram-negative pathogens

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDM-U(02)M]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE Patterning during early development is a product of integration of signaling cues that result in specific gene expression. Gene expression results from transcription factors engaging with the chromatin environment. In this proposal we will investigate the mechanism by which, histone demethylases of the KDM3 family affect gene expression during the early stages of development especially in the specification of primordial germ cells that are precursors to gametes. The results obtained from this proposal will be highly impactful to the fields of early developmental disorders and infertility.

PI_NAMEs: SRIDHARAN, RUPA  (contact)

PROGRAM_OFFICER_NAME: TAYMANS, SUSAN

PROJECT_TERMS: active control;Adenosine;Affect;Arginine;arginine methyltransferase;cell motility;Cell Nucleus;Cells;Chromatin;chromatin immunoprecipitation;Cues;Cytosine;Data;Defect;demethylation;Dependence;design;Development;developmental disease;DNA;DNA Methylation;Elements;embryonic stem cell;Enabling Factors;Environment;Enzymes;Epiblast;Epigenetic Process;epigenetic regulation;epitranscriptome;epitranscriptomics;Event;Excision;Family;Fertilization;Gene Expression;Gene Expression Profile;Gene Silencing;Genes;Genetic;Genome;genome integrity;genome-wide;genomic locus;Germ Cells;Germ Lines;Gonadal structure;histone demethylase;histone modification;Histones;Immunofluorescence Immunologic;implantation;imprint;in vitro Model;in vivo;Infertility;insight;Location;Lysine;Measures;Mediating;Messenger RNA;Methods;Methylation;Methyltransferase;migration;Modification;Mus;non-genetic;Nuclear Translocation;Organism;Pattern;Phenotype;Play;Post-Transcriptional Regulation;posttranscriptional;prevent;protein complex;Proteins;recruit;Repetitive Sequence;Reporting;Repression;RNA;RNA Splicing;Role;Series;Signal Transduction;Specific qualifier value;Structure of primordial sex cell;Testing;Tetanus Helper Peptide;Tissues;Totipotent;transcription factor;transcriptome;transgenerational epigenetic inheritance;transmission process;zygote

PROJECT_TITLE: Histone Demethylase Control of Post Implantation Development


ORG_CITY: MANHATTAN

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: KANSAS STATE UNIVERSITY

ORG_STATE: KS

PHR: Project Narrative Innate immune responses of insect vectors of human diseases are likely to affect the their ability to transmit pathogens to hosts. The long term goals of this research is to gain understanding of proteins in insect hemolymph that mediate innate immune responses, using a model system, Manduca sexta, well suited for biochemical studies. The knowledge gained from this project will enhance understanding of the evolution of innate immune mechanisms and can be applied to future investigations of arthropod disease vectors.

PI_NAMEs: KANOST, MICHAEL R (contact)

PROGRAM_OFFICER_NAME: ZHAO, XIAOLI

PROJECT_TERMS: Affect;Arthropods;Biochemical;Biological Models;Complex;disease transmission;Disease Vectors;Environment;Evolution;Future;Goals;Gram-Positive Bacteria;Hemolymph;human disease;Immune;Immune response;Immunity;Immunologic Tests;Infection;innate immune mechanisms;Innate Immune Response;Innate Immune System;Insect Vectors;Insecta;Invaded;Investigation;Iron;Knowledge;Laboratories;Mammals;Manduca sexta;Mediating;microorganism;Modeling;Modification;Monophenol Monooxygenase;Oxidation-Reduction;Parasites;pathogen;Pathway interactions;Peptide Hydrolases;Peptidoglycan;Plasma;Plasma Proteins;Proteins;Regulation;Research;Serine Protease;Sulfhydryl Compounds;transmission process;Work

PROJECT_TITLE: Function of hemolymph plasma proteins in insect immune responses

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-T(55)R]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Data Science;Machine Learning and Artificial Intelligence;Natural Products;Networking and Information Technology R&D (NITRD)

ORG_DEPT: ZOOLOGY

PHR: Unified Computational Tools for Natural Products Research Approximately 50% of all FDA approved drugs trace their origins to natural products, either directly or through indirect routes of development. To accelerate and make more efficient the study of natural products, we are developing innovative computational tools for the rapid annotation of natural product structures and their associated chemical and biological properties.

PI_NAMEs: COTTRELL, GARRISON W;DORRESTEIN, PIETER C;GERWICK, LENA ;GERWICK, WILLIAM HENRY (contact)

PROGRAM_OFFICER_NAME: BOND, MICHELLE RUEFFER

PROJECT_TERMS: Acceleration;Address;annotation  system;artificial intelligence method;Binding;Biological;Biological Assay;Bite;chemical association;Chemicals;Classification;Communities;computerized tools;Country;Creativeness;Cyanobacterium;Data;Databases;deep learning;deep learning model;Development;drug discovery;Ecosystem;Evaluation;FDA approved;Future;genome sequencing;genomic data;Genomics;Goals;Grant;informatics tool;innovation;Knowledge;Laboratories;Legal patent;Libraries;Machine Learning;Mainstreaming;marine;marine natural product;Mass Spectrum Analysis;metabolomics;Molecular;Molecular Profiling;Molecular Structure;Natural Products;Noise;Nuclear Magnetic Resonance;Occupations;Organism;Paper;Pathway Analysis;Pharmaceutical Preparations;Positioning Attribute;Postdoctoral Fellow;Printing;Process;Property;Publications;quantum;repository;Research;Research Activity;Research Personnel;Resources;Route;small molecule;social;Source;Spectrometry;Structure;Students;System;Technology;tool;web site

PROJECT_TITLE: Unified Computation Tools for Natural Products Research

STUDY_SECTION: SBCB

STUDY_SECTION_NAME: Synthetic and Biological Chemistry B Study Section[SBCB]


NIH_SPENDING_CATS: Aging;Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Infectious Diseases;Microbiome;Nutrition

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: Increasing age is associated with changes in the host immune system and the indigenous microbiota. These changes affect the interaction of the host with bacterial pathogens leading to increased susceptibility to infection and worse clinical outcomes, including infection with the pathogen Clostridiodes difficile. Three teams with complementary expertise in geriatrics, infectious diseases, immunology, bioinformatics, and microbiology will work in animal models systems to understanding how aging leads to the increased burden of infectious diseases.

PI_NAMEs: YOUNG, VINCENT B (contact);YUNG, RAYMOND L

PROGRAM_OFFICER_NAME: BAQAR, SHAHIDA

PROJECT_TERMS: Address;Adipose tissue;adverse outcome;Affect;Age;age effect;age related;age related changes;Aging;Animal Model;Animals;Antibiotics;Bioinformatics;Biological Models;Breeding;Cardiovascular Diseases;Chronic;Clinical;Clostridium difficile;Communicable Diseases;Development;Diabetes Mellitus;Digestion;Disease;disease model;Disease Outcome;Ecosystem;Elderly;Environment;Exhibits;experience;experimental study;fecal transplantation;Food;Fostering;frailty;Geriatrics;Germ-Free;Goals;gut microbiota;Health;host microbiota;host-microbe interactions;Immune;Immune response;Immune system;Immunology;immunosenescence;improved;Indigenous;Individual;Infection;Inflammation;Inflammatory;insight;Invaded;Investigation;life span;Malignant Neoplasms;Mediating;Microbiology;microbiome;microbiome research;microbiota;microbiota transplantation;Modeling;Morbidity - disease rate;mortality;mouse model;Mus;Neurodegenerative Disorders;novel;Obesity;old mice;older adult;older patient;Older Population;Organism;Outcome;pathogen;pathogenic bacteria;Phenotype;Physiology;Play;Predisposition;Prevention;Recurrence;Resources;restoration;Risk;Role;Severities;Severity of illness;Shapes;Structure;Testing;Therapeutic;Work

PROJECT_TITLE: The microbiome and aging in Clostridioides difficile infection

STUDY_SECTION: HIBP

STUDY_SECTION_NAME: Host Interactions with Bacterial Pathogens Study Section[HIBP]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Neurosciences

ORG_CITY: RALEIGH

ORG_NAME: NORTH CAROLINA STATE UNIVERSITY RALEIGH

ORG_STATE: NC

PHR: Project Narrative To navigate our surroundings, the nervous system must identify which of the many stimuli we encounter are threatening enough to require a behavioral response and which can be ignored. Sensory hypersensitivity to innocuous stimuli is a hallmark of many behavioral disorders including autism, anxiety, and schizophrenia. Our research aims to determine the molecular pathways that guide the formation and function of the neural circuits that underlie this sensory filtering, with the long-term goal of establishing approaches for therapeutic intervention in disorders of sensory processing.

PI_NAMEs: MARSDEN, KURT C. (contact)

PROGRAM_OFFICER_NAME: OSBORNE, LESLIE CAROL

PROJECT_TERMS: Acoustics;Actins;Acute;addiction;Affect;Anxiety;Architecture;Auditory;auditory stimulus;autism spectrum disorder;base;Behavior;Behavior Disorders;Behavioral;behavioral phenotyping;behavioral response;Binding;Biological;Biological Models;Brain;Bypass;Calcium;cell type;Cells;Cellular Morphology;Clinical;Complex;Critical Pathways;Cytoplasm;Cytoskeleton;Data;Defect;density;Detection;Development;Disease;DLG4 gene;Electrophysiology (science);Enabling Factors;Epilepsy;Equilibrium;Esthesia;Excitatory Synapse;experience;Fiber;FMR1 gene;Foundations;Genetic;genome wide screen;gephyrin;Glutamates;Goals;Hair Cells;hindbrain;human disease;Hypersensitivity;Image;imaging approach;in vivo imaging;Inhibitory Synapse;Interneurons;Label;Laboratories;Link;Measures;Mediating;Molecular;Molecular Genetics;molecular modeling;Motor Neurons;Movement;Mutagenesis;mutant;Nervous System;Nervous System Physiology;neural;neural circuit;Neurologic Dysfunctions;neuronal circuitry;Neurons;Neurophysiology - biologic function;neuropsychiatric disorder;novel;Optics;optogenetics;Pathway interactions;Peripheral;Phenotype;polymerization;Polymers;Population;programs;promoter;protein protein interaction;Regulation;Reproducibility;Research;response;RNA;Role;scaffold;Schizophrenia;Sensory;sensory processing disorder;sensory stimulus;Site;sound;Startle Reaction;Stereotyping;Stimulus;Structure;Synapses;Testing;Therapeutic Intervention;tool;Transgenic Organisms;Translational Repression;Translations;Variant;Work;Zebrafish

PROJECT_TITLE: Molecular and Cellular Mechanisms of Acoustic Startle Threshold Regulation


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: CORAL GABLES

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: Project Narrative Type 1 diabetes (T1D) occurs when a loss of immune tolerance to insulin-producing beta cells of the pancreas leads to their destruction and blood glucose dysregulation. T1D can be cured with beta cell replacement through pancreatic islet transplantation, but the need for chronic systemic immunosuppression limits the applicability of this procedure. Islet transplantation without the need for chronic systemic immunosuppression can be achieved by encapsulation, where transplanted islets are coated in biocompatible gels that act as a barrier to recipient immune responses. Unfortunately, an indirect immune response still occurs. This proposed project seeks to combine islet encapsulation with two tolerance-inducing therapies that block this indirect immune response, thereby improving the efficacy of encapsulated islet transplantation and its potential for translation to the clinic.

PI_NAMEs: LI, CHRIS MICHAEL (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Address;Alloantigen;Allogenic;anergy;Animal Model;Animals;Antibodies;Antigen Presentation;Antigen-Presenting Cells;Antigens;Attenuated;Autoimmune;Autoimmune Diseases;Beta Cell;beta cell replacement;Binding;Biocompatible Materials;Biodistribution;Biological;biomaterial compatibility;Biomedical Engineering;Blood Glucose;blood glucose regulation;Cell model;Cells;Chronic;Climacteric;Clinic;clinically relevant;Continuous Glucose Monitor;CTLA4 gene;Devices;Diagnosis;Drug Packaging;Encapsulated;engineered stem cells;Environment;Equilibrium;Face;Family suidae;Fatty acid glycerol esters;Gel;Genetic Engineering;Glucose;Goals;Health;Hydrogels;Hyperglycemia;Immune;Immune response;Immune Tolerance;Immunoglobulins;immunoregulation;Immunosuppression;Implant;implantation;improved;In Vitro;in vivo;Individual;Inflammation;Inflammatory;Insulin;Insulin Infusion Systems;insulin secretion;Insulin-Dependent Diabetes Mellitus;insulinoma;intravenous injection;islet;Islets of Langerhans;Islets of Langerhans Transplantation;Kinetics;lymph nodes;Macrophage;Mediating;Metabolic Control;Methods;mouse model;mRNA Expression;Mus;nanoparticle delivery;nanoscale;new technology;novel;Organ Donor;Oxygen;paracrine;Pathway interactions;Patients;Permeability;pharmacologic;Phenotype;Physiological;Polyethylene Glycols;preconditioning;Procedures;protein expression;Protocols documentation;Psyche structure;Recurrence;Refractory;response;Reticular Cell;scaffold;Shapes;Signal Transduction;Site;Stromal Cells;Structure of beta Cell of islet;T cell response;T-Cell Activation;T-Lymphocyte;targeted delivery;Testing;Therapeutic;Thick;Tissue Grafts;translational potential;Transplant Recipients;Transplantation;treatment strategy;uptake;Vascularization;Vesicle

PROJECT_TITLE: Strategies to attenuate the indirect alloimmune response in encapsulated pancreatic islet transplantation


NIH_SPENDING_CATS: Neurosciences

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: Project Narrative  Our main goals are to understand the molecular mechanisms by which neurons activate pathways that induce axon degeneration during development apoptosis and pruning. Apoptosis and pruning are physiologically important as they allow for the removal of excessive or defective neurons or specific axon branches during the establishment of the nervous system. The results from this study will help identify key mechanisms by which axon degeneration occurs during brain development.

PI_NAMEs: DESHMUKH, MOHANISH P (contact)

PROGRAM_OFFICER_NAME: TYLER, WILLIAM A

PROJECT_TERMS: Apoptosis;Apoptotic;Architecture;Area;Axon;axon injury;axonal degeneration;Axotomy;Behavioral;Brain;CASP3 gene;CASP6 gene;Caspase;Caspase Inhibitor;Cells;Defect;deprivation;Development;Devices;Dimerization;Event;Excision;Exhibits;experimental study;Exposure to;Gene Family;Goals;Image;in vivo;Induction of Apoptosis;Injury;Mediating;Mediator;Messenger RNA;Microfluidics;Microscopy;Modeling;Molecular;mRNA Expression;Mus;NAD+ Nucleosidase;Nerve Degeneration;Nervous System;neurodevelopment;neuron apoptosis;neuronal cell body;neuronal survival;Neurons;Neurosciences;novel;Pathway interactions;Physiological;Point Mutation;protein expression;Puma;Research;Resolution;response;Rest;Role;segregation;Signal Transduction;Structure;synaptic pruning

PROJECT_TITLE: Spatial Restriction of Apoptotic Machinery during Neuronal Apoptosis and Pruning

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD]


ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: Narrative HIV-1 establishes a chronic infection that the immune system cannot spontaneously clear. We are studying mechanisms of cell-to-cell transmission of HIV that facilitate immune evasion and promote viral escape by enhancing viral diversity. Knowledge of these mechanisms of immune evasion will help target HIV-infected cells in new vaccine or therapeutic antibody strategies.

PI_NAMEs: CHEN, BENJAMIN K (contact)

PROGRAM_OFFICER_NAME: SHANKAR, UDAY K

PROJECT_TERMS: adhesion receptor;Antibodies;Antibody Response;Bar Codes;Binding;Biochemical;Biological Assay;Biotin;Cell Adhesion;Cell Culture Techniques;Cell Physiology;Cell surface;Cells;Cellular biology;Chimeric Proteins;chronic infection;Combined Modality Therapy;Data;Detection;Endocytosis;Endosomes;Epitopes;Evolution;Face;Genes;genetic manipulation;Glycoproteins;glycosylation;gp160;Heterogeneity;HIV;HIV-1;humanized mouse;Image;Immune;Immune Evasion;Immune response;Immune system;improved;In Vitro;in vivo;Infection;inhibitor;Knowledge;Label;Learning;Lymphoid Tissue;Masks;Measures;Mediating;Membrane Fusion;Modeling;Molecular Conformation;mouse model;mutant;Mutate;neutralizing antibody;novel vaccines;Pathway interactions;Pattern;Peptides;Play;pressure;Process;ratiometric;receptor;recruit;Recycling;response;Role;Shapes;Signal Transduction;single-cell RNA sequencing;Surface;synaptogenesis;synergism;T-Lymphocyte;Testing;Therapeutic antibodies;trafficking;transmission process;vaccine-induced antibodies;Viral;Viral Proteins;Virion;virological synapse;Virus;Virus Diseases;Work

PROJECT_TITLE: HIV immune evasion and escape through T cell virological synapses

STUDY_SECTION: HVCD

STUDY_SECTION_NAME: HIV Molecular Virology, Cell Biology, and Drug Development Study Section[HVCD]


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Intellectual and Developmental Disabilities (IDD);Machine Learning and Artificial Intelligence;Mental Health;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: SEATTLE

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE This proposal will develop and assess a framework for developing culturally-sensitive and highly predictive parental-report screening measures to improve the equity and accuracy of future ASD screeners. Current ASD screeners do not sufficiently account for i) heterogeneity between cultural groups in culture-based parental perceptions of early Autism Spectrum Disorder (ASD) expressions and ii) heterogeneity within cultural groups in the development of social communication behaviors over time, which together impede equitable and accurate ASD screening and timely access to ASD-specialized services. This proposal will apply mixed- methods data collection and analytic techniques in a novel manner to precisely characterize this dual heterogeneity and to develop prototype algorithms that predict ASD in diverse families.

PI_NAMEs: ATTAR, SHANA M (contact)

PROGRAM_OFFICER_NAME: SIMS, BELINDA ENITA

PROJECT_TERMS: African;Age;algorithm development;Algorithms;Attenuated;autism spectrum disorder;autism symptoms;autistic children;Behavior;Behavioral;Brain;Caregivers;Caring;Characteristics;Child;Clinical;communication behavior;Communication difficulty;cost;Cultural Sensitivity;Data Analytics;Data Collection;design;Detection;Development;Developmental Delay Disorders;Diagnosis;Diagnostic;disorder risk;Ecological momentary assessment;economic need;Equity;ethnic minority;Ethnic Population;Exhibits;expectation;Facial Expression;Family;Future;Group Affiliation;Heterogeneity;human old age (65+);improved;Individual;Individual Differences;Inequity;Life;Machine Learning;Measures;Methods;Middle Eastern;minority children;Monitor;novel;Nursery Schools;Outcome;Parents;Perception;phenomenological models;Play;Population;prediction algorithm;prospective;prototype;racial minority;racial population;Recommendation;Reporting;Research;Sampling;School-Age Population;Scientist;screening;Screening procedure;Services;skills;social communication;Social Development;Socioeconomic Status;Specialist;Specificity;Techniques;Time;Toddler;Training;United States;Variant

PROJECT_TITLE: Developing a Framework to Advance Cultural Sensitivity and Accommodate Behavioral Variability in Toddler Autism Screening: A Mixed-Methods Cross-Cultural Approach to Improve Autism Screening Accuracy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F16-L(20)L]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: LA JOLLA

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

PHR: PROJECT NARRATIVE Mitochondrial dysfunction and endoplasmic reticulum (ER) stress are hallmarks of pathologic aging and are intricately linked in the onset and pathogenesis of etiologically-diverse neurodegenerative disorders including Alzheimer’s disease (AD) and related dementias (ADRDs). PERK—an ER stress-responsive kinase that acts as an effector of both unfolded protein response (UPR) and integrated stress response (ISR) signaling—regulates mitochondrial adaptation in response to ER stress and is deficient in neurodegenerative tauopathies such as AD and progressive supranuclear palsy (PSP). Here I will define a critical role for PERK in regulating adaptive mitochondrial remodeling during neurodegeneration, and I will establish pharmacologic ISR activation as a potential therapeutic strategy to mitigate mitochondrial dysfunction and improve neuronal survival in neurodegenerative disease.

PI_NAMEs: BARON, KELSEY ROSE (contact)

PROGRAM_OFFICER_NAME: SARE, RACHEL

PROJECT_TERMS: Affect;Alleles;Alzheimer's Disease;Alzheimer's disease related dementia;Apoptosis;biological adaptation to stress;Biology;Cell Culture Techniques;Cell model;Cells;Cellular Stress;Chronic;Clinical;clinical diagnosis;Complex;Crista ampullaris;Disease;EIF-2alpha;Endoplasmic Reticulum;endoplasmic reticulum stress;Environmental Risk Factor;Etiology;Fibroblasts;Gene Expression Profiling;Genes;Genetic;Genetic Induction;Genetic Transcription;Goals;Health;Human;human model;Impairment;improved;Individual;interest;Link;Membrane;Mitochondria;mitochondrial dysfunction;Modeling;Molecular Chaperones;Morphology;Nerve Degeneration;Neurodegenerative Disorders;neurodegenerative phenotype;Neuronal Dysfunction;neuronal survival;Neurons;Pathogenesis;Pathologic;pathological aging;Pathology;Patients;PERK kinase;pharmacologic;Phospholipids;Phosphorylation;Phosphotransferases;programs;Progressive Supranuclear Palsy;Protein Import;Proteins;Proteolysis;proteostasis;Regulation;respiratory;Respiratory Chain;response;restoration;Role;Signal Induction;Signal Pathway;Signal Transduction;Site;small molecule;Stress;Stress Response Signaling;tau Proteins;Tauopathies;Therapeutic;transcriptome sequencing;Variant

PROJECT_TITLE: Alleviating Mitochondrial Dysfunction in PERK-deficient Neurodegenerative Disease


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Child Abuse and Neglect Research;Mental Health;Mental Illness;Neurosciences;Pediatric;Social Determinants of Health;Violence Research

ORG_DEPT: PSYCHIATRY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Project Narrative Maternal care is one of the most important environmental factors influencing brain development and later vulnerability to maladaptive behaviors. We recently found that the mother’s presence or absence regulates the activity of the prefrontal cortex (PFC) in 11-day-old rat pups through the serotonergic system. In the current proposal, we propose to uncover the mechanisms regulating PFC activity during development and how this affects adaptive behavior in adulthood.

PI_NAMEs: TEIXEIRA, CATIA  (contact)

PROGRAM_OFFICER_NAME: MANN KOEPKE, KATHY M

PROJECT_TERMS: Adaptive Behaviors;Adolescent;Adult;Affect;Anterior;Attention;Attentional deficit;Behavior;behavior test;Behavioral;behavioral outcome;Bipolar Disorder;Brain;caregiving;Caring;cell cortex;Cells;Child;Child Abuse and Neglect;child neglect;Childhood;childhood adversity;cingulate cortex;constriction;Data;designer receptors exclusively activated by designer drugs;Development;Dyes;early life adversity;early life stress;Enterobacteria phage P1 Cre recombinase;Environment;Environmental Risk Factor;executive function;Exposure to;Fluoxetine;food insecurity;Frequencies;Functional disorder;Gene Expression;Image;Impaired cognition;Impulsivity;inhibitor;Ketanserin;Knowledge;Life;Link;Location;Major Depressive Disorder;maladaptive behavior;Maternal Behavior;maternal separation;Memory;Mental disorders;Mental Health;Mothers;Mus;neglect;nerve supply;neural;Neurons;Newborn Infant;novel;object recognition;optogenetics;Pathway interactions;pediatric trauma;physical abuse;Population;Post-Traumatic Stress Disorders;postnatal;postnatal period;Predisposition;Prefrontal Cortex;prepulse inhibition;prevent;Process;pup;Rattus;Reaction Time;receptor;Regulation;response;Risk;Rodent;Role;Schizophrenia;Selective Serotonin Reuptake Inhibitor;Serotonergic System;Serotonin;Shapes;Signal Transduction;single nucleus RNA-sequencing;stressor;Syndrome;Testing;transcriptome;Transgenic Mice;United States;Violence;Viral Vector;voltage;voltage sensitive dye

PROJECT_TITLE: Role of PFC Activity in the Behavioral Deficits Induced by Maternal Separation

STUDY_SECTION: BRLE

STUDY_SECTION_NAME: Biobehavioral Regulation, Learning and Ethology Study Section[BRLE]


NIH_SPENDING_CATS: Biotechnology;Natural Products

ORG_CITY: TAMPA

ORG_NAME: H. LEE MOFFITT CANCER CTR & RES INST

PHR: PROJECT NARRATIVE The development of new synthetic methods in organic chemistry is critical to enabling the continued discovery and production of pharmaceuticals and other chemicals that directly benefit society and public health. This proposal aims to develop a series of novel methods for C–C, C–N, and C–S bond formation that will allow for the rapid preparation of medicinally-relevant scaffolds across a variety of disease states. The newly developed reagents, and their associated reactions and applications, will be of immediate utility to synthetic chemists and chemical biologists in both academic and industrial laboratories.

PI_NAMEs: LOPCHUK, JUSTIN MATTHEW (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TERMS: Acceleration;Alcohols;Amines;Anions;bioactive natural products;Carboxylic Acids;chemical synthesis;Chemicals;Chemistry;Communities;Complex;Development;Diazomethane;direct application;Disease;Drug Delivery Systems;drug discovery;Fluorides;Goals;Hydrazines;Hydrogen Bonding;Industrialization;Industry;Laboratories;Link;Literature;Medicine;Methods;Molecular;Natural Products;Nitrogen;novel;Organic Chemistry;Pharmaceutical Chemistry;Pharmaceutical Preparations;Pharmacologic Substance;piperazic acid;Positioning Attribute;Preparation;Production;programs;Proteomics;Public Health;Reaction;Reagent;scaffold;Series;small molecule therapeutics;Societies;Work

PROJECT_TITLE: New reagents for C-C and C-N bond formation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-Q(55)R]


ADMINISTERING_IC: DA

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Mental Health;Mental Illness;Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Post-Traumatic Stress Disorder (PTSD);Substance Misuse;Suicide

ORG_CITY: KINGSTON

ORG_NAME: UNIVERSITY OF RHODE ISLAND

ORG_STATE: RI

PHR: Project Narrative The co-occurrence of opioid use and suicide is an urgent public health concern that has received growing national attention. The proposed project is the first to disentangle the proximal role of trauma context in subsequent co-occurring opioid use and acute suicide risk in the daily lives of community individuals. Findings will specify time-sensitive and context-dependent risk for co-occurring opioid use and acute suicide risk to inform targeted and trauma-informed prevention and intervention efforts.

PI_NAMEs: RAUDALES, ALEXA  (contact)

PROGRAM_OFFICER_NAME: KURAMOTO-CRAWFORD, SATOKO JANET

PROJECT_TERMS: Acute;adaptive intervention;Address;Adult;Anxiety;Area;associated symptom;Attention;Behavior;Behavioral;Cessation of life;cognitive interview;common symptom;Communities;comorbidity;coping;Coupled;craving;death anxiety;design;Distal;dysphoria;Ecological momentary assessment;Environment;Ethics;evidence base;experience;Feasibility Studies;Feeling suicidal;follow-up;Funding;Future;Goals;Grant;Health;high risk;high risk population;Impulsivity;Individual;individualized medicine;innovation;Institution;Intervention;Knowledge;Link;Literature;longitudinal design;Measures;Mentors;Mentorship;Methodology;Methods;Modeling;multilevel analysis;Myopia;National Institute of Drug Abuse;Nature;novel;Numbness;Opioid;opioid epidemic;opioid overdose;opioid use;Outcome;Overdose;Pattern;Persons;Pharmaceutical Preparations;Phase;Policies;Population;Positioning Attribute;post-traumatic symptoms;premature;Prevalence;Prevention;Process;Protocols documentation;Psyche structure;psychosocial;Public Health;public health priorities;Recording of previous events;recruit;Reporting;Research;Rhode Island;Risk;Risk Factors;risk sharing;Role;Sampling;Self Destructive Behavior;Specific qualifier value;Statistical Models;suicidal;suicidal behavior;suicidal risk;Suicide;suicide rate;Surveys;Technology;tenure track;Time;Training;Trauma;trauma exposure;Typology;United States;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Opioid Use and Acute Suicide Risk: The Real-Time Influence of Trauma Context"


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_DEPT: NEUROSCIENCES

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: Mitochondria produce energy but they also release free radicals that can impair neural cells and contribute to disorders of the brain. Using experimental models, we will test the therapeutic efficacy of uniquely selective blockers of mitochondrial free radicals in dementia-linked pathology, and investigate new candidate mechanisms underlying the effects of free radicals on glial cells. These studies are expected to uncover novel roles of mitochondria in dementia-related processes and new treatment approaches for aging-related disorders of the brain.

PI_NAMEs: ORR, ANNA GOLDSHMIDT (contact)

PROGRAM_OFFICER_NAME: BARRETT, PAUL JOHN

PROJECT_TERMS: Address;Aging;aging related;Alzheimer's Disease;Alzheimer's disease related dementia;Amyloid beta-Protein;apolipoprotein E-4;Astrocytes;behavior test;beta amyloid pathology;Biological Models;blood-brain barrier penetration;Brain;Brain Diseases;Brain Pathology;Cell Culture Techniques;Cells;Cellular Metabolic Process;Coculture Techniques;Cognitive deficits;Complex;Cytosol;Data;Dementia;Disease;Disease Progression;drug development;Electron Transport Complex III;Electrons;Electrophysiology (science);Engineering;Experimental Models;Free Radicals;Gene Expression;genetic manipulation;Homeostasis;hyperphosphorylated tau;Image;Immune;Impairment;in vivo;Individual;inhibitor;insight;interest;Investigation;Link;Mediator;Metabolism;Mitochondria;mitochondrial dysfunction;Modeling;Molecular;motor deficit;mouse model;Mus;Nerve Degeneration;neural;Neurodegenerative Disorders;Neuroglia;Neuroimmune;neuroinflammation;Neuronal Dysfunction;Neurons;neuropathology;Neurophysiology - biologic function;novel;novel therapeutic intervention;Oxidation-Reduction;Oxidative Stress;Pathogenicity;Pathologic;Pathology;Pathway interactions;pharmacologic;pre-clinical;predictive modeling;Process;Production;protein misfolding;Reactive Inhibition;Reactive Oxygen Species;research and development;respiratory;response;Role;sensor;Signal Transduction;single-cell RNA sequencing;Site;small molecule;Synapses;tau dysfunction;tau Proteins;Tauopathies;Testing;Therapeutic;therapeutic evaluation;Therapeutic Studies;tool;transcriptomics;Transgenic Mice;Transgenic Organisms;translational study;Treatment Efficacy;treatment strategy

PROJECT_TITLE: Mitochondrial Complex III Free Radicals in Dementia-Related Proteinopathy and Neuroinflammation


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

PHR: Research Narrative The adult mammalian hippocampus contains neural stem cells that provide a self-renewable source for continuous replenishment of new neurons throughout life, highlighting the striking structural plasticity and regenerative capacity within the mature nervous system. Neurodegenerative diseases, such as Alzheimer’s disease (AD), lead to impaired adult hippocampal neurogenesis in both AD mouse models and human patients likely due to lack of permissive niche environment for neuroregeneration. Therefore, identifying critical neurogenic niche components that promotes sustainable neurogenesis may enable development of novel strategies to enhance functional repair from endogenous NSCs upon neurodegeneration.

PI_NAMEs: SONG, JUAN  (contact)

PROGRAM_OFFICER_NAME: LAVAUTE, TIMOTHY M

PROJECT_TERMS: Address;Adult;adult neurogenesis;Aging;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease pathology;Alzheimer's disease patient;Anti-Inflammatory Agents;Astrocytes;Atrophic;Behavioral;cell behavior;Cells;Cholecystokinin;Chronic;Data;dentate gyrus;Deposition;Development;Electrophysiology (science);Environment;Epilepsy;Exhibits;Genetic;glutamatergic signaling;Glutamates;Goals;granule cell;Hippocampus;Human;IFNGR1 gene;Image;Impairment;in vivo evaluation;Interferon Type II;Interneurons;knock-down;Knowledge;Lead;Life;Mammals;Mediating;Memory;Memory impairment;mouse model;Mus;Nerve Degeneration;Nerve Regeneration;nerve stem cell;Nervous System;Neurites;Neurodegenerative Disorders;neurogenesis;neuroinflammation;neuronal cell body;Neurons;neuropathology;neutralizing antibody;novel strategies;Patients;permissiveness;Play;Production;Proliferating;Radial;Regenerative capacity;Regulation;repaired;Research;Role;Series;Serine;Signal Transduction;Slice;Source;stem cell proliferation;System;Testing;Time;transcriptome sequencing;Up-Regulation

PROJECT_TITLE: Role of Cholecystokinin in the Dentate Gyrus


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Childhood Injury;Pediatric;Physical Injury - Accidents and Adverse Effects

ORG_DEPT: PEDIATRICS

PHR: Project Narrative Injury control is directly related to two overarching goals of Healthy People 2020: (1) Attain high-quality, longer lives free of preventable disease, disability, injury, and premature death; and (2) Achieve health equity, eliminate disparities, and improve the health of all groups. Continued attention to controlling injuries in children and reducing health disparities related to injury remains a foremost challenge for public health, a priority reflected in the 43 injury prevention goals set forth in Healthy People 2020, many of which have not been achieved. This Pediatric Injury Research Training program remains the only comprehensive pediatric injury research training program in the nation that addresses injury and violence of all types.

PI_NAMEs: MC CARTY, CAROLYN A;RIVARA, FREDERICK P. (contact)

PROGRAM_OFFICER_NAME: MAHOLMES, VALERIE

PROJECT_TERMS: Childhood Injury;Research Training;Training Programs

PROJECT_TITLE: Pediatric Injury Research Training Program


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Esophageal Cancer;Precision Medicine;Prevention;Rare Diseases

ORG_CITY: DALLAS

ORG_NAME: BAYLOR RESEARCH INSTITUTE

ORG_STATE: TX

PHR: Project Narrative Over the past 50 years, there has been an eight-fold increase in the frequency of esophageal adenocarcinoma (EAC), a deadly tumor that develops in patients who have gastroesophageal reflux disease (GERD) complicated by a change in the lining of the esophagus called Barrett’s esophagus (BE). The current policy of using endoscopy to identify individuals with GERD symptoms who have BE, and then enrolling BE patients in a program of regular endoscopy to detect pre-cancerous changes has failed to stem the rising frequency of EAC, largely because of the lack of a reliable test to identify which BE patients are at high risk for cancer development. Preliminary studies suggest that a new precision medicine test called TissueCypher can identify BE patients at high risk for cancer development, and the proposed study is designed to validate TissueCypher’s utility as a BE risk-stratification tool, a finding of high relevance to public health that could stem the rising frequency of EAC.

PI_NAMEs: CRITCHLEY-THORNE, REBECCA ;SOUZA, RHONDA F (contact);SPECHLER, STUART JON

PROGRAM_OFFICER_NAME: KLAPPROTH, JAN-MICHAEL AXEL

PROJECT_TERMS: Address;Barrett Esophagus;Biological Assay;Biological Markers;Biopsy;Biopsy Specimen;cancer prevention;cancer risk;carcinogenicity;Case/Control Studies;Categories;Cessation of life;Clinical;clinical practice;clinical risk;cohort;Cohort Studies;Communities;Consumption;cost effective;Data;design;Development;Dysplasia;Early Intervention;Endoscopic Biopsy;Endoscopy;Enrollment;Esophageal Adenocarcinoma;Esophagus;follow-up;Frequencies;Gastroesophageal reflux disease;General Population;Health Care Costs;High grade dysplasia;high risk;High-Risk Cancer;Image Analysis;Image Enhancement;improved;Incidence;Individual;individual patient;innovation;Malignant - descriptor;Malignant Neoplasms;Managed Care;Molecular;Mucous Membrane;Pathology;patient population;Patients;Performance;Policies;Population;precision medicine;premalignant;prevent;Prevention strategy;preventive intervention;programs;progression risk;Protocols documentation;Public Health;Publishing;Randomized, Controlled Trials;Recommendation;Research;Research Design;Retrospective Studies;Risk;Risk Factors;risk prediction;risk stratification;Running;Sample Size;screening;Specimen;standard of care;stem;Stratification;Surveillance Program;Symptoms;technological innovation;Testing;Time;tool;trial comparing;tumor;tumor progression;Validation

PROJECT_TITLE: Stratification of Cancer Risk in Patients with Non-Dysplastic Barrett's Esophagus using TissueCypher: The SCRiBE study

STUDY_SECTION: DNPD

STUDY_SECTION_NAME: Digestive and Nutrient Physiology and Diseases Study Section [DNPD]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Genetics;Pediatric

ORG_CITY: JACKSON

ORG_NAME: UNIVERSITY OF MISSISSIPPI MED CTR

ORG_STATE: MS

PHR: Narrative Misshapen teeth are highly common in humans and most cases are due to a genetic mutation like for the Runx2 gene which, when mutated, causes cleidocranial dysplasia (CCD). Retinoic acid is a signaling molecule that plays a crucial role during tooth induction and that we suspect play a major role during tooth morphogenesis. This proposal will develop new fish models to study the role of retinoid acid and the Runx2 gene during tooth formation, clarifying the mechanisms which cause misshapen teeth in CCD and will identify novel genes implicated in the development and evolution of tooth morphogenesis.

PI_NAMEs: GIBERT, YANN  (contact)

PROGRAM_OFFICER_NAME: SAIFUDEEN, ZUBAIDA

PROJECT_TERMS: Acids;Adult;Affect;autosome;Cell Separation;Cells;Cellular biology;Cleidocranial Dysplasia;comparison control;Complex;CRISPR/Cas technology;Data;Dental;Dentition;Development;differential expression;Disease;DNA Sequence Alteration;Dominant Genetic Conditions;Embryo;Embryonic Development;Enzymes;Epithelium;Evolution;Exposure to;Fishes;Functional disorder;Gene Expression;gene function;Genes;Genetic;genetic analysis;Genetic Diseases;Genetic study;Germ Cells;Goals;Goldfish;Growth Factor;Hand;Heterozygote;Histologic;Human;human disease;Human Genetics;Incisor;inhibitor;Knock-out;knockout gene;Larva;Link;loss of function;malformation;Mesenchymal;Mesenchyme;mineralization;Minnows;Modeling;Molar tooth;Molecular;Molecular Biology;Morphogenesis;morphogens;Morphology;Mus;mutant;Mutate;Mutation;novel;Odontoblasts;Odontogenesis;oral ectoderm;Organ;Organogenesis;Orthologous Gene;Pathway interactions;pharmacologic;Phenotype;Play;Process;Rattus;Receptor Signaling;Regulation;Retinoids;Role;Series;Shapes;Siblings;Signal Transduction;Signaling Molecule;Structure;Syndrome;Techniques;teleost;Testing;Thinness;Tooth Abnormalities;Tooth Cell;Tooth Germ;Tooth structure;transcription factor;transcriptome;Tretinoin;Vertebrates;Work;Zebrafish

PROJECT_TITLE: Mechanisms responsible for tooth morphogenesis in vertebrates

STUDY_SECTION: SBDD

STUDY_SECTION_NAME: Skeletal Biology Development and Disease Study Section[SBDD]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Autoimmune Disease;Dietary Supplements;Digestive Diseases;Genetics;Inflammatory Bowel Disease;Nutrition

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

PHR: Inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, is a family of chronic inflammatory disorders of the gastrointestinal tract that affect over 3 million Americans. This project will define the roles of dietary Mn and SLC39A8 gene that maintain intestinal health, thereby advancing research into the etiology of IBD. Our findings will pave the way for future research to provide dietary recommendations and therapeutic targets for individuals at high risk of IBD.

PI_NAMEs: SEO, YOUNG AH  (contact)

PROGRAM_OFFICER_NAME: MARUVADA, PADMA

PROJECT_TERMS: Acute;Adherent Culture;Affect;American;Animals;Biology;Ceramidase;Chronic;Consumption;CRISPR/Cas technology;Crohn's disease;Data;Dependence;Development;dextran sulfate sodium induced colitis;Diet;dietary;Dietary Fiber;Dietary Manganese;Digestive System Disorders;Disease;disease model;Disease susceptibility;divalent metal;Dose;Environmental Risk Factor;Enzymes;epidemiology study;Epithelial Cells;Etiology;Exhibits;Family;Fatty acid glycerol esters;Food;Future;Genes;Genetic;Genetic Models;genome wide association study;Grain;gut inflammation;Health;high risk;Homeostasis;Human;In Vitro;Incidence;Individual;Inflammatory;Inflammatory Bowel Diseases;inhibitor;insight;Intake;intestinal epithelium;Intestinal permeability;Intestines;Investigation;Ions;Iron;Knock-in Mouse;Knockout Mice;Lead;Lipids;Manganese;manganese deficiency;Meat;Mediating;Metals;Micronutrients;Minor;Mitochondria;mouse model;Mus;Mutant Strains Mice;Mutation;Normal Range;novel;Nutrient;Nutritional;Nuts;Organoids;Patients;Plants;Play;Positioning Attribute;Predisposition;Production;Reactive Oxygen Species;Recommendation;Research;Resources;Rice;Role;Single Nucleotide Polymorphism;Sodium Dextran Sulfate;Source;Testing;therapeutic target;transcriptomics;Ulcerative Colitis;Variant;Vegetables;western diet;Zinc

PROJECT_TITLE: Manganese in Inflammatory Bowel Disease

STUDY_SECTION: INMP

STUDY_SECTION_NAME: Integrative Nutrition and Metabolic Processes Study Section[INMP]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Colorectal Cancer;Digestive Diseases;Genetics;Human Genome;Prevention

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

PHR: NARRATIVE This proposed study will use exceptional resources and cutting-edge technologies to discover proteins associated with risk of colorectal cancer (CRC), investigate the roles of these proteins in colorectal tumor development, and evaluate their key cellular functions. Results from this study will significantly advance our understanding of the genetic basis, biology, and etiology of CRC, accelerating the translation of genetic findings to CRC prevention and patient care.

PI_NAMEs: GUO, XINGYI  (contact);ZHENG, WEI

PROGRAM_OFFICER_NAME: MECHANIC, LEAH E

PROJECT_TERMS: Acceleration;adenoma;Affect;African ancestry;Asia;Asian;Asian ancestry;Asian population;Association of Community Cancer Centers;Biological;Biological Assay;Biological Process;Biology;biomarker identification;Black Populations;Blood Proteins;Blood specimen;Cancer Biology;Cancer Etiology;Cancer Patient;Cancer-Predisposing Gene;Carcinoma;causal variant;Cell Physiology;Cells;Co-Immunoprecipitations;Cohort Studies;Collaborations;Colon;colon cancer cell line;Colon Carcinoma;colon tumorigenesis;Colorectal Cancer;colorectal cancer prevention;colorectal cancer risk;Colorectal Neoplasms;common treatment;Communities;Complex;CRISPR interference;Data;density;Development;Diagnostic;disorder prevention;disorder risk;Epidemiology;Etiology;European;European ancestry;experimental study;Freezing;Gene Expression;gene product;Genes;Genetic;Genetic Models;Genetic Predisposition to Disease;genome wide association study;genomic data;Immunofluorescence Immunologic;improved;In Vitro;in vitro Assay;Incidence;Individual;insight;Length;male health;Malignant Neoplasms;MAP Kinase Gene;Measures;Messenger RNA;Methodology;Methods;Modeling;Nested Case-Control Study;novel;Pathogenesis;Pathway interactions;Patient Care;Patients;Phosphorylation;PIK3CG gene;Pilot Projects;Play;Predisposition;Prevention;Prospective, cohort study;protein biomarkers;Protein Biosynthesis;protein expression;Protein Kinase;Proteins;Proteome;Proteomics;Regulatory Pathway;Research Design;Resources;Risk Assessment;Role;Sampling;Signal Transduction;Susceptibility Gene;Technology;therapeutic development;therapeutic target;Tissues;TP53 gene;transcriptome;transcriptome sequencing;Transforming Growth Factor beta;Translating;translational genetics;Translational Regulation;Translations;tumor progression;United States;Western Blotting;Women's Health

PROJECT_TITLE: Uncovering colorectal cancer etiology and biology by integrating proteomics with other omics data

STUDY_SECTION: CHSB

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology B Study Section[CHSB]


NIH_SPENDING_CATS: Aging

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: A protein’s function depends on its shape. Proteins that do not fold into the correct shape become dysfunctional and can aggregate into toxic structures that cause diseases in all major organ systems. We will study quality control mechanisms that correct protein folding errors or remove damaging protein aggregates, and how these processes contribute to cellular function and protect cells from diseases produced by protein misfolding and aggregation.

PI_NAMEs: PON, LIZA A (contact)

PROGRAM_OFFICER_NAME: MACARTHUR, LINDA

PROJECT_TERMS: Aging;Autophagocytosis;Autophagosome;biological adaptation to stress;Body System;Cardiovascular Diseases;Cell model;Cell Physiology;Cells;Complex;congenital muscular dystrophy;Cytoprotection;Disease;endoplasmic reticulum stress;Endosomes;Excision;fitness;Funding;Future;Gene Delivery;Goals;hatching;In Vitro;Individual;Lead;Life;Link;Lipids;Lysosomes;Mammalian Cell;Mediating;Membrane;Membrane Proteins;Metabolic Diseases;misfolded protein;Mitochondria;Mitochondrial Inheritance;Mitochondrial Matrix;Mitochondrial Proteins;Modeling;multicatalytic endopeptidase complex;Myopathy;Neurodegenerative Disorders;novel;Organelles;Outer Mitochondrial Membrane;Pathway interactions;Peptide Hydrolases;Physiological;Play;Premature aging syndrome;Process;protein aggregation;Protein Biosynthesis;protein folding;Protein Import;protein misfolding;Proteins;proteostasis;Quality Control;reconstitution;repaired;Role;Shapes;Site;Sorting;Structure;TOM translocase;uptake;Vacuole;Yeasts

PROJECT_TITLE: Mitochondrial inheritance and quality control

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-D(55)R]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Bipolar Disorder;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Mental Illness;Neurosciences;Serious Mental Illness

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Bipolar disorders are chronic and debilitating, associated with significant personal and public health costs. The proposed research seeks to address the need to improve treatments for bipolar mood disorders by examining neuromodulation as a new, non-invasive approach to improving treatments for bipolar patients.

PI_NAMEs: ELLARD, KRISTEN K (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: Address;Anatomy;Anterior;Aversive Stimulus;Behavioral;behavioral response;Bipolar Disorder;bipolar patients;Brain;Chronic;Clinical;clinical translation;cognitive reappraisal;Cognitive Therapy;cohort;Computer Assisted;Computer Systems;Data;Development;Distress;Dorsal;Dose;efficacy testing;Electromagnetics;emotion dysregulation;emotion regulation;Emotional;Emotions;Ensure;executive function;experience;Feeling suicidal;Functional disorder;Functional Magnetic Resonance Imaging;functional MRI scan;Future;Goals;Health Care Costs;improved;Individual;individual patient;Inferior;innovation;Insula of Reil;Intervention;Investigation;Literature;Magnetic Resonance;Maintenance;Mentors;Mood Disorders;Network-based;neural;neural circuit;neuroimaging;Neuronavigation;neuroregulation;Neurosciences;Outcome;Parietal Lobe;Participant;Pathology;Pathway Analysis;Patients;Pattern;Performance;pharmacologic;Physiologic pulse;precision medicine;Prefrontal Cortex;Productivity;programs;Psychopathology;psychopharmacologic;psychosocial;Public Health;Randomized;Reaction Time;recruit;Research;Research Proposals;response;Site;specific biomarkers;Statistical Methods;success;suicidal behavior;Synapses;Techniques;Technology;Testing;tool;Training;Transcranial magnetic stimulation;treatment strategy;Work

PROJECT_TITLE: Neuromodulation for Enhancement of Emotion Regulation in Bipolar Mood Disorders


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurosciences;Pediatric;Racial and Ethnic Minority Health Research;Women's Health Research

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

PHR: Project Narrative Maternal psychological risk, characterized as depression and attachment insecurity, negatively impacts caregiving behavior and infant well-being. Increasing research suggests that neurocognitive mechanisms underscoring maternal sensitivity may represent one pathway through which maternal psychological risk affects caregiving and infant adjustment – although this research is generally limited by focusing largely on European ancestry women. Therefore, the proposed study seeks to examine whether maternal risk factors undermine maternal sensitivity and infant adjustment (including attachment security and behavioral problems) as a function of infant temperament through measurements of maternal brain functioning across the transition to motherhood in 200 European American and 200 African American nulliparous expectant mothers and their children.

PI_NAMEs: GROH, ASHLEY MARIE;RUTHERFORD, HELENA JV (contact)

PROGRAM_OFFICER_NAME: MILLER, BRETT

PROJECT_TERMS: Adult;Affect;African;African American;African American Women;American;Attention;Behavior;Belief;biomarker identification;Birth;Brain;brain research;caregiving;Characteristics;Child;Child Rearing;Child Welfare;Cognition;cohort;Color;Communities;Cues;depressive symptoms;design;Development;developmental psychology;Discrimination;Distress;Electroencephalography;Emotional;Emotions;Enrollment;ethnic difference;ethnic diversity;Ethnic Origin;European;European ancestry;Expectancy;experience;Face;Family;health disparity;infancy;Infant;infant outcome;infant temperament;innovation;intergenerational;Intervention;Knowledge;Life Cycle Stages;Link;Longitudinal Studies;maternal caregiving;maternal depression;maternal risk;Measurement;Mediating;Mental Depression;Mental Health;Modeling;motherhood;Mothers;Nature;neural;neuroadaptation;Neurocognitive;neuromechanism;Neuronal Plasticity;Nulliparity;offspring;Outcome;Parents;Pathway interactions;Perception;Personal Satisfaction;Persons;physical conditioning;postnatal;Postpartum Period;Pregnancy;Pregnant Women;prenatal;Problem behavior;Process;prospective;psychologic;Psychological Impact;psychosocial;Research;Risk;Risk Factors;Role;Sampling;Security;social;Social support;stem;Testing;Third Pregnancy Trimester;Time;vigilance;Woman;Work

PROJECT_TITLE: Neural mechanisms of psychological risk on mother and infant adjustment in African American and European American families

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Behavioral and Social Science;Brain Disorders;Cocaine;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Neurodegenerative;Neurosciences;Prevention;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: BIRMINGHAM

ORG_NAME: SOUTHERN RESEARCH INSTITUTE

ORG_STATE: AL

PHR: PROJECT NARRATIVE  Infection by human immunodeficiency virus (HIV) that causes the acquired immune deficiency syndrome (AIDS) is a major global public health problem. Increasing number of HIV-infected persons are living longer due to combined antiretroviral therapies, and a significant population of such patients suffer from neurocognitive impairments known as HIV-associated neurocognitive disorders (HAND). Development of potential therapeutic approaches for the treatment of HAND will have a significant impact as there are currently no approved drugs for treatment of HAND in HIV-positive patients.

PI_NAMEs: AUGELLI-SZAFRAN, CORINNE ELIZABETH (contact);ZHU, JUN

PROGRAM_OFFICER_NAME: BORGMANN, KATHLEEN RUTH

PROJECT_TERMS: Acceleration;Acquired Immunodeficiency Syndrome;Address;analog;Animal Model;antiretroviral therapy;Attention;Attenuated;attenuation;Behavioral;behavioral pharmacology;behavioral study;Binding;Binding Sites;Biochemical;Biological Assay;blood-brain barrier crossing;blood-brain barrier penetration;Brain;candidate identification;Cells;Central Nervous System;Chemosensitization;Cocaine;Cocaine Abuse;cocaine reward;Cognition;Cognitive;Cognitive deficits;Complex;conditioned place preference;design;Development;Docking;Dopamine;dopamine transporter;dopaminergic neuron;Dose;Drug Design;Drug Kinetics;drug of abuse;efficacy evaluation;Feedback;Functional disorder;genetic regulatory protein;Genetic Transcription;Goals;HIV;HIV Seropositivity;HIV-1;HIV-associated neurocognitive disorder;Homeostasis;Human;Impaired cognition;Impairment;improved;in silico;In Vitro;in vivo;Incidence;Individual;Infection;Kinetics;Lead;lead optimization;lead series;Learning;Ligands;Mediating;Memory;Metabolic;Modeling;monoamine;Moods;Motivation;Mus;mutant;neuroAIDS;Neurocognitive;Neurocognitive Deficit;Neurologic;Neuroprotective Agents;neurotoxicity;neurotransmission;novel;novel strategies;Patients;Penetration;Performance;Periodicity;Permeability;Persons;Pharmaceutical Chemistry;pharmacologic;Pharmacology Study;Pharmacotherapy;Physiological;Play;Population;prevent;Prevention;Prevention strategy;Property;Proteins;Public Health;Publishing;Quinazolines;Research;Research Personnel;reuptake;Rewards;Role;Series;Severities;Site;small molecule;Solubility;Structure;Structure-Activity Relationship;Synapses;Testing;Therapeutic;Therapeutic Agents;Therapeutic Intervention;Trans-Activators;Transcription Coactivator;Transgenic Mice;transmission process;uptake;Virus Diseases;Virus Replication;Work

PROJECT_TITLE: Allosteric Modulators of Dopamine Transporter as Therapeutic Agents for NeuroAIDS


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;HIV/AIDS;Human Genome;Infectious Diseases

ORG_CITY: COLD SPRING HARBOR

ORG_NAME: COLD SPRING HARBOR LABORATORY

PHR: Retroviruses 2021-2024 Narrative HIV/AIDS is now a major pandemic in human beings throughout the world. According to the World Health Organization, almost 80 million people have been infected with the HIV virus since the beginning of the epidemic, and almost 40 million people have died of HIV. Sub-Saharan Africa remains most severely affected, with nearly 1 in every 20 adults living with HIV and accounting for nearly 71% of the people living with HIV worldwide. Many conferences around the world address a plethora of issues related to the treatment of HIV/AIDS, but few do so by addressing the underlying biology of the virus, and even fewer do this by putting the molecular biology of the virus and its interaction with its human host in the broader context of how all retroviruses, irrespective of host, function and evolve. A key to the success of the Cold Spring Harbor annual retroviruses conference is that the majority of oral presentations are given by graduate students, postdoctoral fellows and junior faculty chosen on the basis of scientific merit, ensuring that the conference showcases the latest developments which are often yet to be published. Participants come from academic centers, research institutes and industrial centers around the world to present and discuss their findings. Many of the currently important treatments for HIV/AIDS were first presented or proposed at this conference in past years. Importantly, this application requests support for junior scientists who might not otherwise be able to attend to actively participate in the meeting. We are proposing to host four annual iterations of this important conference in spring 2021, 2022, 2023 and 2024.

PI_NAMEs: STEWART, DAVID J. (contact)

PROGRAM_OFFICER_NAME: GUTIERREZ, MARTIN

PROJECT_TERMS: Accounting;Acquired Immunodeficiency Syndrome;Address;Adult;Adult T-Cell Leukemia/Lymphoma;Affect;Africa South of the Sahara;Animals;Anti-Retroviral Agents;Anti-viral Agents;antiretroviral therapy;Apoptosis;Area;Attention;Autoimmune Diseases;Biochemistry;Biology;Bovine leukemia;career;career development;CD4 Positive T Lymphocytes;Cell fusion;Cells;Cellular Immunity;Chickens;Complex;Cytotoxic T-Lymphocytes;Data;Dendritic Cells;Development;Disease;DNA;Embryo;Endogenous Retroviruses;Ensure;Environment;Enzymes;Epidemic;Equine Infectious Anemia;Etiology;Event;Evolution;Faculty;Family Felidae;Fostering;Future;General Population;Generations;Genetic;Genetic Transcription;Genome;Germ Lines;Germination;Goals;graduate student;Helper-Inducer T-Lymphocyte;HIV;HIV Infections;Horizontal Disease Transmission;Human;Human Genome;Immune system;Individual;Industrialization;Industry;Infection;Institution;Integration Host Factors;interest;International;Interview;Investigation;Laboratories;lectures;leukemia;Life;Life Expectancy;Lymphocyte;Macrophage;Mediation;meetings;Mentors;Molecular Biology;Multiple Sclerosis;Mus;Opportunistic Infections;Oral;pandemic disease;Participant;particle;Pathogenesis;Persons;Pharmaceutical Preparations;Phase;Placentation;Play;Positioning Attribute;Postdoctoral Fellow;posters;Predisposition;Published Comment;Publishing;Request for Applications;Research Institute;Research Personnel;Resistance;Retroviridae;Retrovirology;Reverse Transcription;RNA;RNA-Directed DNA Polymerase;Role;Sarcoma;Scientist;Seasons;Senior Scientist;Series;Structure;success;symposium;Therapeutic;Time;Tropical Spastic Paraparesis;undergraduate student;Vaccines;Viral;viral transmission;Virus;Woman;Work;World Health Organization

PROJECT_TITLE: CSHL Retroviruses Conference (2021-2024)


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Serious Mental Illness

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: PROJECT NARRATIVE We recently developed a form of neuromodulation that induces remission in 90% of individuals with TRD (SAINT). SAINT-induced remission is associated with connectivity changes that suggest improved regulation of emotion. This project aims to further elucidate the nature of the connectivity changes produced by SAINT.

PI_NAMEs: WILLIAMS, NOLAN R. (contact)

PROGRAM_OFFICER_NAME: ANKUDOWICH, ELIZABETH

PROJECT_TERMS: Acceleration;Anterior;Attenuated;attenuation;Behavior;Behavioral;Brain;cingulate cortex;Clinical;clinical effect;Cognitive;Data;depressive symptoms;Development;Devices;Diagnosis;disability;disease heterogeneity;Disease remission;Dose;effective therapy;emotion regulation;Ethics;experimental study;FDA approved;Functional Magnetic Resonance Imaging;functional MRI scan;Future;Goals;healthy volunteer;Hour;Human;improved;Individual;innovation;Learning;Left;Link;Magnetic Resonance Imaging;Major Depressive Disorder;Measurable;Measurement;Measures;Mental Depression;Methodology;Modification;Moods;Motor;Motor Evoked Potentials;Nature;neural circuit;neural network;Neurobiology;neuropsychiatry;neuroregulation;Neurosciences;novel;open label;Participant;Pathologic;Patients;Pattern;Phase;Physiologic pulse;Prefrontal Cortex;reduce symptoms;Regulatory Element;Remission Induction;Remission Induction Therapy;repetitive transcranial magnetic stimulation;Resistance;response;response biomarker;Rest;Risk;side effect;Symptoms;System;Techniques;Technology;Therapeutic;tool;Treatment Effectiveness;treatment-resistant depression

PROJECT_TITLE: Utilizing changes in human brain connectivity to establish a dose-response relationship involved in the therapeutic actions of prefrontal brain stimulation on depression symptoms


ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

PHR: Project Narrative In order to address diseases that affect our population, we must ensure that our researchers are representative of the full range of our population. The University of Alabama at Birmingham (UAB) has a strong track record of training diverse undergraduates, especially from Historically Black Colleges and Universities (HBCUs) and those of Hispanic/Latino descent. UAB STEP-UP will enhance the diversity of the nation’s research workforce by providing mentored research training, research education, and robust team-mentoring to promising undergraduate students from diverse backgrounds underrepresented in biomedical, clinical, and behavioral research.

PI_NAMEs: FOUAD, MONA N. (contact);GARVEY, W TIMOTHY

PROGRAM_OFFICER_NAME: BODDIE, THOMAS ARTIS

PROJECT_TERMS: Address;Advocate;Affect;Alabama;Area;Behavioral Research;Biomedical Research;career;Clinical Research;cohort;Collaborations;Country;Diabetes Mellitus;Digestive System Disorders;Discipline;Disease;Distance Learning;E-learning;Education;education research;Educational Activities;Elements;Endocrine System Diseases;Ensure;Ethnic Origin;Ethnic Population;experience;Funding;Future;Goals;Graduate Education;graduate school;Hematological Disease;Hispanic;Historically Black Colleges and Universities;Hour;improved;innovation;interest;Investments;Kidney Diseases;Latino;learning strategy;Maintenance;Mentors;Metabolic Diseases;Mission;National Institute of Diabetes and Digestive and Kidney Diseases;next generation;Nutrition Disorders;Obesity;Participant;Performance;Persons;Population;Process;Professional Education;programs;Race;racial population;recruit;Research;Research Personnel;Research Training;rural area;Schools;Science;science, technology, engineering, mathematics, and medicine;skills;Socioeconomic Status;Structure;Students;success;summer research;tool;Training;Training and Education;undergraduate student;Underrepresented Minority;underrepresented minority student;Underrepresented Students;Universities;Urologic Diseases;virtual;virtual education;virtual group

PROJECT_TITLE: UAB STEP-UP: Promoting Diversity through Team Mentored Research Experiences


NIH_SPENDING_CATS: Bioengineering;Kidney Disease

ORG_CITY: TUCSON

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: PROJECT NARRATIVE  The prevalence of end-stage renal failure (ESRD) has increased ~40% over 20 years, but the kidney-related biomedical workforce has been unable to keep pace. New pathways to a career in nephrology and kidney-related medicine and research are vitally needed that combine early and frequent experiential opportunities to engage in patient-oriented kidney care and contribute to innovative technologies that will one-day change how renal dysfunction is diagnosed and treated. ADVANCE Kidney Health responds to this need by assembling diverse mentors, interdisciplinary infrastructure and novel engineering technologies to impact career trajectories and develop the new technological cures of tomorrow.

PI_NAMEs: ARABYAN, ARA ;BROSIUS, FRANK C;SLEPIAN, MARVIN J;WERTHEIM, JASON A (contact)

PROGRAM_OFFICER_NAME: MARIC-BILKAN, CHRISTINE

PROJECT_TERMS: Acceleration;Active Learning;Acute Renal Failure with Renal Papillary Necrosis;Address;Anatomy;Arizona;Biomedical Engineering;bridge program;Businesses;cancer therapy;career;career development;Career Mobility;career preparation;Caring;Chemical Engineering;Chronic Kidney Failure;Clinical;cohort;Collaborations;college;Computers;Coupled;COVID-19;Critical Thinking;Dedications;design;Diabetes Mellitus;Diagnosis;Dialysis procedure;Disease;Disparity;early experience;Education;education research;Elderly;Elements;End stage renal failure;Endowment;Engineering;experience;Faculty;Future;Generations;graduate school;graduate student;Growth;hands on research;Health;Hypertension;Immersion;Infrastructure;innovation;innovative technologies;interest;Internal Medicine;Internships;Kidney;Kidney Diseases;kidney dysfunction;Laws;Legal patent;Machine Learning;Mechanics;Medical;medical schools;Medicine;Mentors;Mentorship;Motivation;Nephrology;new technology;novel;Optics;Pathway interactions;Patient Care;patient oriented;Patients;Physicians;Physiology;Population;Prevalence;Problem Solving;product development;programs;Ramp;recruit;Renal function;Research;Research Personnel;response;Running;Science;Scientist;skills;Solid;Stimulus;Structure;student participation;Students;summer research;Technology;technology development;Technology Transfer;Thinking;Time;Training;translational progress;Translational Research;Translations;undergraduate education;undergraduate student;United States;Universities

PROJECT_TITLE: Arizona Technology Development and Clinical Education Program for Students in Kidney Health (ADVANCE Kidney Health)