NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Cystic Fibrosis;Genetics;Lung;Orphan Drug;Patient Safety;Precision Medicine;Rare Diseases

ORG_CITY: LITTLE ROCK

ORG_NAME: ARKANSAS CHILDREN'S HOSPITAL RES INST

ORG_STATE: AR

PHR: Our proposal will change the paradigm of care for CFTR modulators, which are a novel class of therapeutic compounds for people with CF. The data we obtain, which will be from the largest study of people with CF on modulator therapy, will help ensure patients are able to personalize therapeutic strategies using a combination of genetics, individual modulator concentrations, and dose titration. This proposal addresses critical knowledge gaps in CF therapy identified by both Francis Collins, former NIH director and NIH’s 2022 conference on the future of CF research, to better understand metabolism enzyme pharmacogenomics, modulator pharmacokinetics, and individualization of modulator dosing.

PI_NAMEs: GUIMBELLOT, JENNIFER S (contact)

PROGRAM_OFFICER_NAME: LACHOWICZ-SCROGGINS, MARRAH ELIZABETH

PROJECT_TERMS: ABCB1 gene;Address;Affect;Age;American;Anxiety;Area;autosome;Behavior;Body System;Caring;Carrier Proteins;Chlorides;Clinical;clinical effect;Clinical effectiveness;clinical implementation;Clinical Trials;Cognition;Combined Modality Therapy;Concentration measurement;cost;CYP3A4 gene;Cystic Fibrosis;cystic fibrosis patients;Cystic Fibrosis Transmembrane Conductance Regulator;Cytochrome P450;Data;Data Set;Defect;Dependence;design;Deterioration;Development;Disease;Dose;Drug Exposure;Drug Kinetics;drug metabolism;Education;Ensure;Enzymes;Equilibrium;evidence base;experience;Family;Functional disorder;Future;Genes;Genetic;Genetic Polymorphism;genetic variant;Genetic Variation;Goals;Guidelines;Health;health care service utilization;improved;Individual;individualized medicine;Influentials;innovation;inter-individual variation;Knowledge;Laboratories;Life;Life Expectancy;life span;Link;Lung;Lung Diseases;Measures;Mental Depression;Mentors;Metabolism;Minority Groups;Modeling;Multicenter Studies;Neuropsychology;novel;novel drug class;novel therapeutics;Nutritional status;Observational Study;optimal treatments;Outcome;Patient Care;patient oriented;Patients;personalized approach;personalized care;personalized therapeutic;Persons;Pharmaceutical Preparations;pharmacogenetic variants;Pharmacogenetics;Pharmacogenomics;Pharmacologic Substance;Pharmacology;Pilot Projects;Plasma;Population;precision medicine;Precision therapeutics;Principal Investigator;prospective;Prospective Studies;Proteins;Psychology;pulmonary function;Quality of life;Race;Recommendation;repository;Research;response;Risk;Risk Reduction;Role;Sample Size;Science;sex;side effect;Specimen;statistics;symposium;Testing;Therapeutic;time use;Tissues;Titrations;tool;treatment response;United States National Institutes of Health;Variant;VX-770;Weight;Work

PROJECT_TITLE: ENsuring ACcess to optimal Therapy in CF: ENACT study

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


ADMINISTERING_IC: HL

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cancer;Cardiovascular

ORG_CITY: BALTIMORE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOCHEMISTRY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: PROJECT NARRATIVE Inflammation and angiogenesis are integral parts of wound healing process, but in pathological conditions, these two processes contribute to the development of cardiovascular diseases and the progression of tumor growth and metastasis. Fibrin(ogen) plays a significant role in these processes. We have recently discovered that endothelial N-cadherin is a novel receptor for fibrin. Our preliminary data suggest that the interaction of fibrin or its fragments with this receptor inhibits leukocyte transmigration, thereby reducing inflammation, and promotes angiogenesis. The primary objectives of the proposed study are: to establish the structural basis for this interaction, to clarify its role in fibrin-dependent inflammation and angiogenesis, and to design efficient anti-inflammatory and anti-angiogenesis agents that can be developed as potent therapeutics for treatment of fibrin-dependent inflammatory disorders and angiogenesis-related tumorigenesis.

PI_NAMEs: MEDVED, LEONID V. (contact)

PROGRAM_OFFICER_NAME: WARREN, RONALD Q

PROJECT_TERMS: Amino Acids;angiogenesis;Angiogenesis Inhibitors;Animal Model;Anti-Inflammatory Agents;Antiinflammatory Effect;atherogenesis;Binding Sites;cadherin 5;Cardiovascular Diseases;cell type;Data;design;Development;Disease;Endothelial Cells;Endothelium;Exhibits;experimental study;Fibrin;fibrin receptor;Fibrinogen;Funding;Hemostatic function;Inflammation;Inflammatory;inhibitor;Leukocytes;migration;Molecular;mutant;N-Cadherin;Neoplasm Metastasis;novel;Pathologic;Pathologic Processes;Pathway interactions;Physiological Processes;Plasma Proteins;Play;Polymers;prevent;Process;Property;protective effect;Proteins;receptor;Receptor Inhibition;Role;Structure;Suggestion;Testing;Therapeutic;Thrombosis;tumor;tumor growth;tumor progression;Tumor Promotion;tumorigenesis;Very low density lipoprotein;VLDL receptor;wound healing

PROJECT_TITLE: Fibrin(ogen) Structure and Interactions

STUDY_SECTION: HTBT

STUDY_SECTION_NAME: Hemostasis, Thrombosis, Blood Cells and Transfusion Study Section[HTBT]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Depression;Drug Abuse (NIDA only);Genetics;Human Genome;Mental Health;Mental Illness;Neurosciences;Substance Misuse

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Psychedelics are considered important therapeutic agents for the treatment of several neuropsychiatric disorders, including substance use disorders (SUDs) and major depression. Both SUDs and depression share common etiological elements that predispose individuals to develop these diseases, including exposure to chronic environmental stress. This project focuses on a molecular mechanism implicated in SUDs that is triggered by immune cells following chronic psychological stress, and is sensitive to psilocybin treatment, which implicates a neuroimmune interaction induced by chronic stress to the predisposition of SUDs.

PI_NAMEs: WHEELER, MICHAEL ALEX (contact)

PROGRAM_OFFICER_NAME: VEMURI, KIRAN R V

PROJECT_TERMS: activin A;addiction;Address;Antibodies;Antiinflammatory Effect;Area;Astrocytes;Behavior;Behavioral;behavioral response;Bone Marrow;Brain;Cell Communication;Cell Separation;cell type;Cells;chemokine receptor;Chimera organism;Chronic;Chronic stress;Clinical Trials;combat;Corticosterone;CRISPR screen;cytokine;Cytometry;Data;Disease;drug craving;drug seeking behavior;Elements;Environmental Risk Factor;Etiology;Exposure to;Functional disorder;Genetic;Genetic Screening;Genetic Transcription;genome-wide;genomic tools;Goals;Growth Factor;Hallucinogens;Hematopoietic;HTR2A gene;Immune;Immune response;Immune system;Immunity;Immunologics;in vivo;Incubators;Individual;Inflammatory;Inflammatory Response;INHA gene;Inhibin A;Interleukin-6;ITGAM gene;Link;Major Depressive Disorder;Meningeal;Meninges;Mental Depression;Microfluidics;Molecular;monocyte;Mood Disorders;Mus;Myeloid Cells;Nervous System;neural circuit;Neuroimmune;neuromechanism;Neurons;neuropsychiatric disorder;Nucleic Acids;Nucleus Accumbens;Operant Conditioning;Pathogenicity;Peripheral;Plasma;Population;Predisposition;Production;Psilocybin;Psychological Stress;Public Health;receptor;receptor expression;Receptor Signaling;recruit;Regulation;Research;response;Rewards;serotonin receptor;Serotonin Receptor 5-HT2A;Signal Induction;Signal Transduction;single cell genomics;Stress;Substance Use Disorder;Testing;Therapeutic;Therapeutic Agents;therapeutic evaluation;therapeutic target;tool;Transgenic Organisms;United States;Ventral Striatum;Work

PROJECT_TITLE: A Psilocybin-Sensitive Neuroimmune Circuit Controlling Stress Behaviors

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 BSW-N (M2)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cardiovascular;Cerebrovascular;Dementia;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Neurodegenerative;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: NEW HAVEN

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Narrative This project consists of an integrated experimental-computational strategy to elucidate in depth the regulatory networks that govern angiogenesis, arteriogenesis and vascular remodeling. We will acquire quantitative experimental data on effects of specific perturbations on the signaling and gene expression pathways that govern endothelial responses to VEGF and fluid shear stress, from which w cSTAR will develop a quantitative causal model. Key model predictions will then be tested experimental in vitro and in vivo.

PI_NAMEs: SCHWARTZ, MARTIN A (contact);SIMONS, MICHAEL

PROGRAM_OFFICER_NAME: GAO, YUNLING

PROJECT_TERMS: Address;angiogenesis;arterial remodeling;Arteries;Biological Process;Blood flow;Blood Vessels;Candidate Disease Gene;Carotid Arteries;causal model;Cells;Cerebral Arterial Diseases;Cerebrovascular Disorders;Collaborations;computer framework;Computer Models;Corneal Neovascularization;Coronary Arteriosclerosis;Data;Diameter;Disease;Disease susceptibility;Endothelial Cells;Endothelium;Ensure;Failure;femoral artery;Gene Expression;Gene Proteins;Genes;Growth;Health;Hemangioma;Hindlimb;Human;improved;In Vitro;in vitro testing;in vivo;in vivo Model;insight;Ischemia;Knock-out;Knowledge;Laboratories;large scale data;Ligation;Liquid substance;malformation;Malignant Neoplasms;Measures;Mediator;Metabolism;Methods;Modeling;mouse model;Mus;Neoplasm Metastasis;new therapeutic target;novel;Nutrient;Outcome;outcome prediction;Oxygen;Pathway interactions;Peripheral arterial disease;Phenotype;Physiological;predictive modeling;predictive test;Process;Publishing;Recording of previous events;Regulation;Regulatory Element;response;Role;shear stress;Signal Transduction;Signaling Protein;Specific qualifier value;System;Testing;therapeutic development;therapeutic target;Tissues;Vascular blood supply;Vascular Dementia;Vascular Diseases;Vascular Endothelial Cell;Vascular Endothelial Growth Factors;Vascular remodeling;Vascular System;Work

PROJECT_TITLE: A QUANTITATIVE, PREDICTIVE MODEL OF VASCULAR REMODELING IN HEALTH AND DISEASE

STUDY_SECTION: MABS

STUDY_SECTION_NAME: Modeling and Analysis of Biological Systems Study Section[MABS]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics;Neurosciences

ORG_CITY: NEW YORK

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: Narrative  Human vision critically depends on normal development of the cornea and its ability to focus light on the retina. Model organisms have been an important tool for understanding other human diseases, but a lack of knowledge has prevented them from being used to study disorders of corneal development such as myopia, hyperopia, astigmatism, keratoconus or corneal dystrophy. This proposal will investigate how the cells that produce the corneal lens of the fruit fly Drosophila differentiate and how the corneal lens itself is organized, with the goal of using this system to model human corneal diseases and test treatments for them.

PI_NAMEs: TREISMAN, JESSICA E (contact)

PROGRAM_OFFICER_NAME: MCKIE, GEORGE ANN

PROJECT_TERMS: Address;Affect;Apical;Astigmatism;Binding;Biology;Blindness;Cell Differentiation process;Cell secretion;cell type;Cells;Chromatin;Chromatin Structure;Complement Factor B;Cone;Cornea;Corneal Diseases;Corneal dystrophy;Crystallins;Data;Deposition;Development;Differentiated Gene;Disease;Drosophila genus;Ecdysone;Enhancers;experimental study;Extracellular Matrix;Extracellular Protein;fly;Gene Expression;Genes;Genetic;genetic corepressor;Genetic Diseases;Genetic Enhancer Element;Genetic Models;Genetic Transcription;genome-wide;Glass;Goals;Human;human disease;human model;Hyperopia;Keratoconus;Knowledge;Label;lens;lens morphogenesis;Light;Link;loss of function;Mass Spectrum Analysis;Methods;model organism;Modeling;Molecular;Morphogenesis;Morphology;mutant;Mutation;Myopia;Nature;Neuroglia;Neurons;organizational structure;Photoreceptors;Pigments;prevent;Process;Production;programs;Proteins;Refractive Errors;Retina;Role;Specific qualifier value;Specificity;stem cells;steroid hormone;Structure;System;Testing;Time;tool;transcription factor;transcriptomics;Vision;Vision Disorders;Work;XCL1 gene

PROJECT_TITLE: Development and function of corneal lens-secreting cells

STUDY_SECTION: BDE

STUDY_SECTION_NAME: Biology and Development of the Eye Study Section[BDE]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Kidney Disease;Lung;Nutrition;Rare Diseases

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: Using mouse models, we found that iron deficiency strongly potentiated inflammatory lung and kidney injury. We aim to define the underlying mechanism of this adverse interaction. The topic is of outstanding translational importance given the high global prevalence of both iron deficiency and inflammation.

PI_NAMEs: NEMETH, ELIZABETA  (contact)

PROGRAM_OFFICER_NAME: SADUSKY, ANNA BURKART

PROJECT_TERMS: Acute;Acute Lung Injury;Acute Renal Failure with Renal Papillary Necrosis;Adverse effects;adverse outcome;Anemia;Apoptosis;burden of illness;Cell Physiology;Cessation of life;Chronic;Clinical;Clinical Research;cofactor;comorbidity;Country;CREB1 gene;Data;Disease;Disparity population;endoplasmic reticulum stress;Endothelial Cells;Endothelium;Foundations;Functional disorder;Future;Genes;Health;Heart failure;High Prevalence;Human;Impaired Renal Function;In Vitro;Income;Indigenous;Infection;Inflammation;Inflammation Mediators;Inflammatory;Inflammatory Response;Injury;Injury to Kidney;Investigation;Iron;iron deficiency;Iron deficiency anemia;Kidney;Link;Liver;Low Income Population;Lung;lung injury;Macrophage;Mediating;Migrant;Molecular;monocyte;mouse model;Mus;Neutrophil Infiltration;NF-kappa B;novel;Organ;Outcome;Pathogenicity;Pathway interactions;Pediatric Acute Respiratory Distress Syndrome;Persons;Phenotype;Physiological Processes;Pre-Clinical Model;Prevalence;Prevention;Process;Production;programs;Publishing;Recommendation;Regulation;Research;Role;Sepsis;Severities;Severity of illness;Signal Transduction;Spleen;Sterility;synergism;systemic inflammatory response;Text;TFRC gene;tissue injury;Tissues;transcription factor;translational impact;United States;Work

PROJECT_TITLE: Iron deficiency worsens inflammatory tissue injury: mechanisms and outcomes

STUDY_SECTION: NMHD

STUDY_SECTION_NAME: Nutrition and Metabolism in Health and Disease Study Section[NMHD]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: COLD SPRING HARBOR

ORG_NAME: COLD SPRING HARBOR LABORATORY

PHR: Project Narrative Cancer is a leading cause of death worldwide, with more than 14 million new cases and 8 million deaths each year. New advances in sequencing technology are uncovering the genomic mechanisms that drive cancer development and progression including the complex genetic, transcriptomic, and epigenetic drivers of this disease. Expertise and comfort in these new approaches are essential to a successful cancer research program to facilitate better diagnosis and treatment options.

PI_NAMEs: GOODWIN, SARA  (contact)

PROGRAM_OFFICER_NAME: JOHNSON, ERIC MICHAEL

PROJECT_TERMS: Address;Automobile Driving;Biology;Cancer Center;cancer genomics;Cancer Research Project;Cancer Science;cancer subtypes;Cause of Death;Cells;Cessation of life;Collaborations;Complex;Core Facility;Coupled;Development;Diagnosis;Disease;DNA;DNA sequencing;Epigenetic Process;Fostering;Genetic;Genome;genome sciences;genome sequencing;Genomics;Goals;Head;Heterogeneity;Human Genome;improved;innovation;insight;Interdisciplinary Study;Laboratories;Length;Malignant Neoplasms;Methods;Mission;Modification;novel strategies;Phenotype;Population Group;Research;Research Personnel;Resource Sharing;Resources;RNA;Technology;tool;transcriptomics;Variant;Vision;Work

PROJECT_TITLE: The Development and Optimization of Long-Read Sequencing Applications to Cancer Genomics in a Core Setting

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-1 (M2)]


ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Project Narrative The current clinical approach for preventing vascular re-occlusion following the treatment of cardiovascular disease has the drawback of inducing endothelial dysfunction and thrombosis as side effects. Our objective is to pioneer an alternative strategy with low or no thrombogenic risks to reduce mortality, morbidity, and financial costs inflicted upon millions of patients

PI_NAMEs: GUO, LIANWANG ;KENT, K CRAIG (contact)

PROGRAM_OFFICER_NAME: DANTHI, NARASIMHAN

PROJECT_TERMS: Acetylation;Address;Angioplasty;Animal Model;antiproliferative drugs;Arteries;Automobile Driving;Benefits and Risks;Biochemical;Biological Assay;Biomimetics;Blood Vessels;capsule;Cardiovascular Diseases;Cell Line;Cell Physiology;Cell Proliferation;Chronic;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Collagen Type IV;Complex;Coronary Occlusions;cytokine;Cytoprotection;Data;Disease;Dose;Down-Regulation;Endothelial Cells;endothelial dysfunction;Endothelium;Engineering;EP300 gene;Financial cost;Formulation;Functional disorder;Genes;Heart;Histologic;Homing;Human;human data;Hyperplasia;Impairment;In Vitro;in vivo;Inflammation;Inflammatory;Injectable;injured;Injury;Intercellular adhesion molecule 1;Interleukin-1 beta;Interleukin-6;Kidney;knock-down;Knock-out;Liposomes;live cell imaging;Liver;Measurable;Mechanics;Membrane;Metabolism;Modeling;Molecular;Morbidity - disease rate;mortality;Mus;mutant;nanoparticle;nanopolymer;neutrophil;NF-Kappa B p65;novel;novel strategies;Nuclear;Nuclear Translocation;Operative Surgical Procedures;Organ;p300/CBP-Associated Factor;p65;Patients;Peripheral;pharmacologic;Physiological;preservation;prevent;Procedures;Process;Proteins;Rattus;reconstitution;Recovery;Recurrence;Recurrent disease;restenosis;Risk;Rodent;Role;side effect;Signal Transduction;single-cell RNA sequencing;siRNA delivery;Site;Small Interfering RNA;Smooth Muscle Myocytes;Stains;Stents;Stretching;System;Tail;targeted delivery;targeted treatment;Testing;Therapeutic;therapeutic siRNA;thrombogenesis;Thrombosis;thrombotic;Tissues;TNF gene;Torpedo;Transcriptional Regulation;transcriptomics;Translating;Translations;Up-Regulation;Veins;Work;wound;wound healing

PROJECT_TITLE: Targeted suppression of ALDH1A3 for endothelial beneficial management of restenosis after vascular surgery

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Obesity;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: Newark

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: PROJECT NARRATIVE While the NIH has highlighted the “development and testing of interventions…to address food insecurity and neighborhood-level access to healthy and affordable foods” as a priority research area, little is known about how best to intervene across the food system to improve the diets and health of adolescents. This study uses systems science approaches to prioritize food systems interventions targeting adolescents living in low-income urban settings in Nairobi, Kenya by: 1) characterizing the food and home environments that adolescents have access to; 2) quantifying the influence of those environments on adolescent food preferences, dietary patterns, and malnutrition; and 3) co-designing food systems interventions with key community stakeholders, and using project data to rank these interventions based on their feasibility and likely impact on adolescent food choices, nutrition insecurity, and malnutrition.

PI_NAMEs: DOWNS, SHAUNA  (contact);LEE, GWENYTH O'NEILL

PROGRAM_OFFICER_NAME: ROSS, SHARON A

PROJECT_TERMS: Address;Adolescence;Adolescent;adolescent health;Adolescent Nutrition;Adolescent obesity;Adult;Area;Bayesian Modeling;Beverages;Biological Models;Body mass index;Caregivers;Cessation of life;Cognitive;Collaborations;Communities;community-level factor;critical period;Data;Decision Analysis;Decision Making;design;Development;Diet;Diet Habits;dietary;Dietary intake;Dietary Practices;Disease;disorder risk;Eating;Economics;Environment;Equity;experience;experimental study;Exposure to;Family;Focus Groups;Food;food environment;food insecurity;Food Preferences;Goals;good diet;Growth;Health;Health Services Accessibility;Hemoglobin;Home;Home environment;Hour;Household;improved;Individual;Inequity;Infrastructure;innovation;Intervention;Interview;Kenya;Knowledge;Lived experience;low and middle-income countries;Low income;Malnutrition;Maps;Measurement;Measures;Mediator;Methodology;Methods;Micronutrients;Modeling;Morbidity - disease rate;Neighborhoods;novel;nutrition;Nutritional;Nutritional status;Nutritional Study;Obesity;Outcome;Overweight;Pattern;Perception;Personal Satisfaction;Persons;Policy Maker;Population;prevent;Price;primary caregiver;Research;Research Priority;Sampling;Schools;Science;Security;Services;social;standardize measure;Strategic Planning;Surveys;System;Testing;Thinking;Time;United States National Institutes of Health;urban setting;Water;Work

PROJECT_TITLE: [R01] Prioritizing food systems interventions to reduce adolescents’ nutrition insecurity and malnutrition in low-income settings

STUDY_SECTION: CIHB

STUDY_SECTION_NAME: Community Influences on Health Behavior Study Section[CIHB]


ADMINISTERING_IC: AR

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Arthritis;Bioengineering;Nutrition;Obesity;Physical Injury - Accidents and Adverse Effects;Rehabilitation

ORG_CITY: SAINT LOUIS

ORG_DEPT: ORTHOPEDICS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE. Individuals with obesity are at higher risk of tendon injury than individuals without obesity, but how obesity affects tendon homeostasis and healing is not fully understood. This study investigates obesity-mediated effects of altered mechanical load and metabolic dysfunction on tendon structure, function, and gene transcription during homeostasis (Aim 1) and when healing from injury (Aim 2). This work will elucidate the effect of obesity on tendon homeostasis and healing and provide critical training opportunities for the primary investigator to leverage animal studies for translational tendon science.

PI_NAMEs: ZELLERS, JENNIFER  (contact)

PROGRAM_OFFICER_NAME: PINTUCCI, GIUSEPPE

PROJECT_TERMS: achilles tendon;Address;adipokines;Advisory Committees;Affect;Animal Model;Animals;Appearance;Award;Basic Science;Behavior;Biochemical;Biological;Biology;Biomechanics;Blood Glucose;blood glucose regulation;Body Weight;Body Weight decreased;Characteristics;Clinical;clinical care;clinical investigation;Collagen;Counseling;Degenerative polyarthritis;Delaware;Diet;Disease;Doctor of Philosophy;Dose;Environment;exercise training;experience;Faculty;Fatty acid glycerol esters;Fellowship;Funding;Future;Gait;Gene Expression;Genetic Transcription;Genotype;Glean;Goals;healing;Heterozygote;High Fat Diet;high risk;Histologic;Histology;Homeostasis;Human;human subject;human tissue;hypercholesterolemia;Hyperglycemia;Hyperlipidemia;Impaired healing;Impairment;improved;in vivo;Individual;Inflammatory;inflammatory milieu;Injury;Institution;Intervention;Investigation;K-Series Research Career Programs;Kinesiology;Knee Osteoarthritis;Laboratories;Lipodystrophy;Measures;mechanical load;Mechanics;Mediating;medical schools;Medication Management;Mentors;Metabolic dysfunction;Metabolic syndrome;Methods;Modeling;Molecular;Morphology;mouse model;Muscle;Non obese;Obesity;Observational Study;Operative Surgical Procedures;Orthopedic Surgery;Orthopedics;Outcome;Outcome Assessment;Pain;Patient Care;Patients;Performance;Persons;pharmacologic;physical therapist;Physical therapy;Positioning Attribute;post-doctoral training;Postdoctoral Fellow;Pre-Clinical Model;preclinical study;Prevalence;Principal Investigator;professor;Rehabilitation therapy;Research;Research Personnel;research study;Risk;Science;Serum;Signal Transduction;Skeletal Muscle;skills;soft tissue;standard of care;Techniques;Tendinopathy;Tendon Injuries;Tendon structure;tenure track;Testing;Tissues;tool;Training;training opportunity;Translating;translational research program;translational scientist;treatment and outcome;treatment effect;treatment strategy;Universities;Washington;Work

PROJECT_TITLE: Effect of obesity on Achilles tendon homeostasis and healing: Disentangling mechanical load and metabolic syndrome

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Skin Cancer

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE Transcription factors represent one of the largest groups of oncogenes yet are traditionally considered undruggable. By employing chemical proteomic based drug discovery screens, we have identified a covalent ligand that binds to and disrupts the activity of the oncogenic transcription factor SOX10 in melanoma cells. The goal of this application is to use a suite of advanced chemical-proteomic and genomic technologies to understand the mode of action of this covalent ligand, its potential for optimization and the impact of pharmacological inhibition of SOX10 in melanoma models.

PI_NAMEs: BAR-PELED, LIRON  (contact);LIAU, BRIAN

PROGRAM_OFFICER_NAME: AGYIN, JOSEPH KOFI

PROJECT_TERMS: Address;Affinity;analog;anti-cancer research;Antineoplastic Agents;Applications Grants;Binding;Binding Sites;Biochemical;Biological;Biological Models;biophysical techniques;Biotin;Cancer Model;cancer subtypes;cancer therapy;Cell Line;Cells;Characteristics;Chemicals;ChIP-seq;Complex;Cysteine;Dependence;Derivation procedure;Development;DNA Binding;drug discovery;Drug Targeting;Elements;Enzymes;Foundations;functional genomics;Future;Genes;Genetic;Genetic Transcription;Genomics;Glues;Goals;Growth;Human Genetics;Immune;improved;inhibitor;Intervention;Label;Learning;Libraries;Ligand Binding;Ligands;Malignant Neoplasms;Medicine;Melanoma;Melanoma Cell;Metabolic;Methods;Modeling;Molecular;Monitor;Mutate;Mutation;next generation;novel;Oncogenes;Oncogenic;Outcome;Patients;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacologic;Phosphotransferases;preclinical development;programs;Proliferating;protein protein interaction;Proteins;Proteome;Proteomics;Regulation;Reporter;Research;Role;Shapes;Site;Skin Cancer;small molecule;small molecule inhibitor;spheroids;success;Synthesis Chemistry;targeted treatment;Technology;Testing;tool;transcription factor;Transcription Factor Oncogene;transcriptome sequencing;tumor;tumorigenesis;Validation

PROJECT_TITLE: Identification of Covalent Transcriptional Dependencies in Melanoma

STUDY_SECTION: CBP

STUDY_SECTION_NAME: Chemical Biology and Probes Study Section[CBP]


NIH_SPENDING_CATS: Biotechnology;Cancer;Hematology;Immunotherapy;Lymphatic Research;Lymphoma;Orphan Drug;Rare Diseases

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: RELEVANCE STATEMENT/NARRATIVE Diffuse large B-cell lymphoma is the most common lymphoid neoplasm in adults. Despite of good responses to standard treatments more than forty percent of patients develop therapy resistance. This R50 application for NCI Research Specialist Award requests salary support for Dr. Serganova in the frame of the Dr. Zappasodi program to understand how specific inhibitors for lymphoma can enhance the immunotherapy responses.

PI_NAMEs: SERGANOVA, INNA  (contact)

PROGRAM_OFFICER_NAME: LIN, CHARLES

PROJECT_TERMS: Accounting;Adult;Advanced Development;Affect;Animals;Antigen Targeting;Antitumor Response;Award;B-Cell NonHodgkins Lymphoma;Biological Models;cancer cell;Cancer Model;Cell Physiology;Cells;Clinical;clinical application;clinically relevant;Data;Dedications;Development;effective therapy;experience;Failure;Foundations;Funding;Generations;Grant;Growth;Hematology;imaging approach;imaging modality;Imaging technology;Immune;Immune Evasion;Immune mediated destruction;Immunotherapy;inhibitor;interest;Knowledge;Laboratories;Laboratory Research;large cell Diffuse non-Hodgkin's lymphoma;lymphoid neoplasm;Lymphoma;Medicine;Metabolic;Molecular;Mus;Neoplasm Metastasis;neoplastic cell;non-invasive monitor;novel therapeutic intervention;Oncology;Pathway interactions;Patients;Permeability;Primary Neoplasm;programs;Research;Resistance;response;Role;Scientist;Seminal;Specialist;standard care;System;T cell response;T cell therapy;T-Lymphocyte;therapy development;therapy resistant;Time;trafficking;tumor;Tumor Biology;Tumor Escape;tumor metabolism;tumor microenvironment;Tumor-infiltrating immune cells;Wages

PROJECT_TITLE: Exploiting tumor metabolism to optimize T cell therapy


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Neurodegenerative;Neurosciences

ORG_DEPT: PATHOLOGY

PHR: PROJECT NARRATIVE Neurodegenerative diseases, like Alzheimer's, have massive accumulation of proteins such as tau, which is linked to the failure of the cellular recycling system known as autophagy. A unique protein called BOK connects an intricate signaling network between autophagy and cellular survival. This project will elucidate the metabolic pathways regulated by BOK in order to reveal potential mechanisms by which to prevent tau-mediated death of neurons.

PI_NAMEs: KATZ, SAMUEL G (contact)

PROGRAM_OFFICER_NAME: MCGAVERN, LINDA

PROJECT_TERMS: Ablation;Address;Alzheimer's Disease;Apoptosis;Apoptotic;Autophagocytosis;BCL1 Oncogene;Binding;Biochemical;Brain;Calcium;calcium phosphate;Cell Death;Cell Death Induction;Cell Membrane Permeability;Cell Survival;Cells;Chemicals;Data;defined contribution;Endoplasmic Reticulum;endoplasmic reticulum stress;Equilibrium;Exhibits;Failure;Family member;Functional disorder;Genetic;Goals;Homeostasis;hyperphosphorylated tau;Impairment;Induced Neurons;Induction of Apoptosis;Injury;innovation;inositol 3-phosphate;interdisciplinary approach;intravital microscopy;Lead;Link;lipid metabolism;lipidomics;Lipids;Measures;Mediating;Membrane;Metabolic;Metabolic Control;Metabolic Pathway;Metabolism;metabolomics;Mitochondria;Molecular;Mus;Nerve Degeneration;Neurodegenerative Disorders;Neurofibrillary Tangles;neuron loss;Neurons;new therapeutic target;novel;Outer Mitochondrial Membrane;Ovarian;overexpression;Pathologic;Pathway interactions;Play;prevent;Process;Production;Proteins;proteotoxicity;Recycling;Regulation;resilience;response;Role;Shapes;Signal Pathway;Signal Transduction;Site;Stimulus;Stress;Structure;System;targeted treatment;tau aggregation;tau mutation;tau Proteins;Tauopathies;Techniques;therapeutic development;tool;two-photon;Work

PROJECT_TITLE: Cell Death Regulation by Pro-Apoptotic BOK in Tauopathies

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Coronaviruses;Coronaviruses Therapeutics and Interventions;Dental, Oral, and Craniofacial Disease;Emerging Infectious Diseases;Infectious Diseases;Lung;Neurosciences;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

PHR: PROJECT NARRATIVE: Among the unique symptoms of COVID-19 are the abrupt and profound loss of smell and taste. While transient disruption of normal smell and taste is associated with many upper respiratory infections, the sudden onset and degree of severity are key distinguishing symptoms of COVID-19. Importantly, up to 4% of patients who recover from COVID-19 have persistently distorted sense of smell and/or taste 6-12 months later. Although current studies have identified disruption of the normal architecture of the olfactory neuroepithelium and of olfactory neuron signaling in patients with persistent COVID19 chemosensory dysfunction, the mechanistic determinants of persistence are still unclear. This proposal seeks to define the relevant mediators derived from uniquely dysregulated immune cells of patients with persistent COVID19 chemosensory dysfunction, the cellular targets of these mediators and how they disrupt the normal developmental and survival trajectories in the olfactory mucosa.

PI_NAMEs: BANKOVA, LORA  (contact)

PROGRAM_OFFICER_NAME: SULLIVAN, SUSAN L

PROJECT_TERMS: 2019-nCoV;Afferent Neurons;Anosmia;Anti-Inflammatory Agents;Architecture;Biological Response Modifiers;Biology;Cell Differentiation process;cell type;Cells;cellular targeting;Characteristics;chemokine;Chronic;chronic rhinosinusitis;Clinical;Clinical Data;Clinical Sciences;Computing Methodologies;COVID-19;COVID-19 associated anosmia;CSF1R gene;Cystic Fibrosis;Data;Development;Disease;Dryness;Dysgeusia;Dysosmia;Environment;Epithelial Cells;Epithelium;Esthesia;experience;Functional disorder;Generations;Genes;Genetic Transcription;Glioblastoma;Glioma;Glycoproteins;Goblet Cells;Homeostasis;Human;human subject;Immune;immune cell infiltrate;Immunophenotyping;immunosuppressive macrophages;In Vitro;Incidence;ineffective therapies;Infiltration;Inflammation;Inflammation Mediators;Inflammatory;inflammatory milieu;insight;Linoleic Acids;lipid mediator;Lipids;Liquid substance;Long COVID;Macrophage;Maps;Measures;Mediator;Melanoma;Methods;Molecular;monocyte;Mus;Myelogenous;Nasal Epithelium;nasal obstruction;nasal swab;Natural regeneration;Neuroepithelial;neuroepithelium;neuron apoptosis;neuron development;neuronal survival;neurotransmission;neurotrophic factor;Neutrophil Infiltration;Nonmetastatic;Nose;novel;Olfactory Epithelial Cell;Olfactory Mucosa;olfactory sensory neurons;online registry;Pathway interactions;Patients;Phenotype;Physiological;PLAUR gene;Population;post SARS-CoV-2 infection;post-COVID-19;Proliferating;protein B;Proteins;Recovery;recruit;Reporting;respiratory;Respiratory Mucosa;Sampling;SARS-CoV-2 variant;Sensory;Severities;Smell Perception;Source;stem cell proliferation;stem cells;Steroid Resistance;Steroid therapy;Steroids;Structure of mucous membrane of nose;Supporting Cell;Swab;Symptoms;Syndrome;System;Taste Perception;Testing;TGFBI gene;therapeutic development;Time;tool;treatment response;tumor;Upper Respiratory Infections;Urokinase;Viral

PROJECT_TITLE: Immune dysregulation mechanisms of persistent post-COVID19 olfactory dysfunction

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


NIH_SPENDING_CATS: Bioengineering;Complementary and Integrative Health;Neurosciences;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_CITY: DETROIT

ORG_DEPT: GENETICS

ORG_NAME: WAYNE STATE UNIVERSITY

ORG_STATE: MI

PHR: Narrative: This project will use an innovative, non-invasive technology, which is based on infrared light, to target the mitochondria, the so-called powerhouses of the cell, in the injured spinal cord. The treatment attenuates increase in reactive oxygen species production, which is detrimental to neuronal cell regeneration.

PI_NAMEs: HUETTEMANN, MAIK  (contact);MALEK, MOH H.

PROGRAM_OFFICER_NAME: KUMSA, DOE WONDWOSSEN

PROJECT_TERMS: Acute;Address;Animal Model;Area;Attenuated;Blood;Blood Circulation;Blood flow;Cadaver;Calcium;cell regeneration;Cells;central gray matter;Cessation of life;Clinic;clinical implementation;Collaborations;Computer Simulation;cytochrome c oxidase;Data;design;Dose;Drug Delivery Systems;Electron Transport;Enzymes;Euthanasia;Event;Family suidae;Fiber Optics;Free Radicals;Generations;Homeostasis;Human;Hyperactivity;Inflammatory Response;Injury;innovation;Intervention;Intrinsic factor;Lasers;Legal patent;Lesion;Light;manufacture;Manufacturer;Medical Device;Membrane;Methods;Methylprednisolone;Mitochondria;mitochondrial dysfunction;Mitochondrial Proteins;Modeling;motor recovery;nerve injury;neurological recovery;neuron loss;neuron regeneration;Neurons;neuroprotection;novel strategies;Ohio;Oxidases;Pathogenesis;Penetration;phantom model;pharmacologic;Pharmacologic Substance;Phase;Phase I Clinical Trials;Phototherapy;portability;prevent;Production;Publishing;Rattus;Reactive Oxygen Species;Research;response;response to injury;Riluzole;Rodent;Site;Source;Spinal Cord;Spinal Cord Contusions;Spinal cord injury;Structure;Surgical Decompression;System;Technology;Testing;Therapeutic;Therapeutic Effect;Time;tissue injury;Tissues;Translating;Vertebral column;white matter;Work

PROJECT_TITLE: Non-invasive infrared light therapy and medical device to treat spinal cord injury

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-Q (91)]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Contraception/Reproduction;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Hypertension;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Physical Activity;Pregnancy;Prevention;Racial and Ethnic Minority Health Research;Women's Health Research

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: NARRATIVE Black women are more likely to get high blood pressure in pregnancy (preeclampsia) and heart failure later in life. This study will look for heart failure risk in women who had preeclampsia. The results might help find women who we can help keep heart-healthy after pregnancy with medicine and lifestyle modifications.

PI_NAMEs: LINDLEY, KATHRYN  (contact)

PROGRAM_OFFICER_NAME: DESVIGNE-NICKENS, PATRICE

PROJECT_TERMS: Activities of Daily Living;Address;Adult;Age;American;angiogenesis;Area;Biochemical;Biological Markers;Black race;black women;Blood Vessels;cardiometabolic risk;Cardiovascular Diseases;Cardiovascular system;Characteristics;Clinical;clinical phenotype;Clinical Research;Data;Development;Discipline of obstetrics;Disease;Early identification;Echocardiography;EFRAC;endothelial dysfunction;Endothelium;Enrollment;Epidemiology;Exercise;exercise capacity;Exercise stress test;Exhibits;experience;Functional disorder;Funding;Future;Gestational Age;Gestational Diabetes;Gravid;Heart;Heart failure;hemodynamics;high risk;High Risk Woman;Hypertension;hypertension control;hypertensive heart disease;Image;Impairment;Inflammation;Inflammatory;Infrastructure;Interruption;Intervention Studies;Kinetics;Lead;Left;Leg;Life;Life Style Modification;lifestyle intervention;Link;maternal morbidity;maternal risk;Measures;Medicine;Minority;Modeling;Modification;molecular phenotype;multidisciplinary;Myocardial;Myocardial dysfunction;normotensive;Obesity;Pathogenesis;Pathway interactions;Patients;Perinatal;PGF gene;pharmacologic;Phenotype;Population;post pregnancy;Postpartum Period;Pre-Eclampsia;Pregnancy;premature;preservation;Prospective Studies;protein expression;Proteinuria;Proteome;Proteomics;Race;recruit;Registries;Reporting;response;Rest;Risk;Risk Adjustment;Risk Factors;risk stratification;Severities;Small for Gestational Age Infant;Stress;Stress Tests;Subgroup;Syndrome;Target Populations;Time;Underrepresented Populations;United States National Institutes of Health;vascular inflammation;Vascular remodeling;Ventricular;Ventricular Remodeling;VO2max;Weight;Woman;Women's Group;Women's mortality;Women's study;Work;young woman

PROJECT_TITLE: Identification of Early HFpEF after Preeclampsia by Exercise Stress Testing

STUDY_SECTION: CCHS

STUDY_SECTION_NAME: Clinical Integrative Cardiovascular and Hematological Sciences Study Section[CCHS]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_DEPT: BIOLOGY

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: Project Narrative: Accumulated neuronal DNA damage is thought to contribute to age-associated cognitive decline and neurodegeneration. The proposed study investigates the molecular mechanisms by which neurons repair genomic damage stemming from repeated neural circuit activation throughout life.

PI_NAMEs: GREENBERG, MICHAEL ELDON (contact);GRIFFITH, ERIC C

PROGRAM_OFFICER_NAME: GRAY, ERIN EMILY

PROJECT_TERMS: Address;age related;Age-associated memory impairment;aged;Aging;aging process;aging related;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease risk;Attenuated;Autopsy;Biochemical;Brain;Central Nervous System;chromatin remodeling;Cognitive;Cognitive aging;combat;comparative;Complex;Coupled;Coupling;Data;Defect;DNA;DNA Damage;DNA Double Strand Break;DNA Repair;DNA Repair Pathway;DNA Sequence Alteration;Double Strand Break Repair;driving force;Elements;Exhibits;experimental study;Gene Expression;Genes;Genetic;Genetic Transcription;genome integrity;Genome Stability;genome-wide;Genomic Instability;Genomics;Human;Impaired cognition;in vivo;Induced Neurons;inhibitor;insight;Laboratories;Life;life span;Maps;Mediating;Methods;Molecular;mouse model;Mus;Nature;Nerve Degeneration;neural;neural circuit;Neuronal Plasticity;Neurons;normal aging;novel;NPAS4 gene;Nucleotides;Physiological;postmitotic;preservation;Process;programs;Recurrence;Regulatory Element;Repair Complex;repaired;Resolution;response;Risk;Sampling;Sensory;Series;Site;Somatic Mutation;stem;Stimulus;System;Testing;therapeutic development;transcription factor;Wild Type Mouse;Work

PROJECT_TITLE: Neuronal activity-responsive DNA repair mechanisms and cognitive aging

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Genetics;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: GENT

ORG_COUNTRY: BELGIUM

ORG_FIPS: BE

ORG_NAME: FLANDERS INTERUNIV INST BIOTECHNOLOGY

PHR: NARRATIVE Frontotemporal lobar degeneration (FTLD) is a group of progressive neurodegenerative disorders with an early onset, profoundly impacting patients and their families' quality of life. While it is known that the genetic makeup of an individual impacts their responses to certain phenotypes, and thereby their susceptibility to developing FTLD, the mechanism through which this happens remains elusive. The studies proposed here combine the use of patient-derived human stem cells and cellular factors linked to neurodegeneration to build a novel mouse model of FTLD with the potential to contribute to the understanding of and ability to diagnose and treat patients with FTLD and similar neurodegenerative diseases.

PI_NAMEs: MANCUSO, RENZO ;RADEMAKERS, ROSA  (contact)

PROGRAM_OFFICER_NAME: LI, TONG

PROJECT_TERMS: Affect;Age;Alzheimer's Disease;Antibody Therapy;Biological Markers;Biotin;Brain;brain cell;Brain region;brain tissue;candidate validation;Cell Nucleus;cell type;Clinical;clinical diagnosis;Code;cohort;Communication;Data;Data Set;Dementia;Diagnosis;Disease;Disease susceptibility;early onset;Elderly;Environment;epigenomics;Exposure to;Family;fitness;frontal lobe;Frontotemporal Lobar Degenerations;Functional disorder;Genetic;Genetic Engineering;genetic makeup;Genetic Risk;GRN gene;Haplotypes;Human;Human Engineering;human induced pluripotent stem cells;human stem cells;Immunoprecipitation;improved;in vivo Model;Individual;insight;Integral Membrane Protein;Label;Late Onset Alzheimer Disease;Ligase;Link;loss of function mutation;Lysosomes;Microglia;Modeling;Molecular;mouse model;Mus;Nerve Degeneration;Neurodegenerative Disorders;neuroinflammation;neuron loss;Neurons;neuropathology;novel;overexpression;Pathologic;Pathology;Patients;Peptides;Personality;PGRN gene;Phenotype;Physiology;Predisposition;Protein Secretion;protein TDP-43;Proteins;Proteomics;Protocols documentation;Quality of life;Regulation;response;Risk;Sampling;Shapes;single nucleus RNA-sequencing;Stress;Symptoms;TDP-43 aggregation;Temporal Lobe;theories;therapeutic target;transcriptomics;translational potential;transplant model;Transplant Recipients;Transplantation;Untranslated RNA;validation studies;Variant;verbal;Xenograft procedure

PROJECT_TITLE: The TMEM106B-GRN-TDP43 triad: leveraging human samples and humanized models to unravel FTLD-TDP disease mechanisms


ORG_CITY: CHARLESTON

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: NARRATIVE The overall goal is to determine the molecular mechanisms by which sphingolipid analog drug FTY720 and its functional analogs, such as A7-2, suppress non-small cell lung cancer (NSCLC) growth and/or proliferation via targeting cytoplasmic SET oncoprotein and inducing ceramidosome-mediated necroptosis.

PI_NAMEs: OGRETMEN, BESIM  (contact)

PROGRAM_OFFICER_NAME: CHEN, WEIWEI

PROJECT_TERMS: analog;Animal Model;anti-cancer;Antineoplastic Agents;Binding;Biological;Bradycardia;Cancer Patient;cancer therapy;Cardiotoxicity;Cell Death;Cell membrane;Ceramides;Clinic;Clinical;clinically significant;Coin;Colon Carcinoma;Complex;Cryoelectron Microscopy;Cytoplasm;Data;design;Development;dihydroceramide desaturase;Disease;Exhibits;experimental study;Generations;Genetic;Goals;Growth;Immunosuppression;Immunosuppressive Agents;improved;in vivo;inhibitor;KRAS2 gene;leukemia;Lipids;lung cancer cell;Lung Neoplasms;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant Neoplasms;MAPK3 gene;MAPK8 gene;Mediating;Membrane;mimetics;Modeling;Molecular;Molecular Biology;Multiple Sclerosis;Multiprotein Complexes;mutant;N-palmitoylsphingosine;Names;nanomolar;new therapeutic target;non-muscle myosin;Non-Small-Cell Lung Carcinoma;Nonmuscle Myosin Type IIA;novel;novel therapeutic intervention;Nuclear Envelope;Oncoproteins;overexpression;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;pharmacologic;Phosphoric Monoester Hydrolases;Phosphorylation;Precision therapeutics;prevent;Prodrugs;Proliferating;protein complex;Protein Dephosphorylation;Protein phosphatase;Protein Phosphatase Inhibitor;Proto-Oncogene Proteins c-akt;PTK2 gene;Publishing;Ras Inhibitor;Refractory;Reporting;RIPK1 gene;Role;Rupture;Signal Transduction;Sphingolipids;Sphingosine;sphingosine kinase;structural biology;Testing;Therapeutic;tool;Treatment outcome;tumor;tumor growth;Tumor Suppression;Tumor Suppressor Proteins;United States;X-Ray Crystallography

PROJECT_TITLE: Targeting cytoplasmic SET oncoprotein by sphingolipid analog drugs for the induction of necroptosis to treat lung cancer

STUDY_SECTION: MCTC

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics C Study Section [MCTC]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Cancer;Genetics;Infectious Diseases

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE DNA from pathogens and the host organism can bind innate immune receptors, resulting in the activation of key cytokine and signaling pathways to initiate immunity. This proposal will address two understudied but important questions in this field. The first concerns the fine structure of DNA that activates key DNA-binding receptors and the second concerns the roles of these receptors in adaptive immune cells, thus extending their functions beyond the confines of innate immunity.

PI_NAMEs: TING, JENNY P (contact)

PROGRAM_OFFICER_NAME: KELLY, HALONNA R

PROJECT_TERMS: activating transcription factor 3;Affect;Affinity;Apoptosis;B-Cell Activation;B-Lymphocytes;Binding;Biochemical;Biological Assay;biophysical analysis;C-terminal;CASP1 gene;Cells;Complex;Cyclic GMP;cytokine;Development;Dinucleoside Phosphates;DNA;DNA Binding;DNA Structure;DNA-Binding Proteins;ds-DNA;Electron Microscopy;Enzymes;Event;Family;functional outcomes;Gene Activation;Guanosine Triphosphate;Human;IL18 gene;Immune;Immunity;Immunologic Receptors;In Vitro;in vivo;Inflammasome;Inflammatory;innate immune function;Interferon Type I;Interferons;Interleukin-10;IRF3 gene;Knowledge;Length;Ligase;Lymphocyte;marenostrin;Mediating;Mediator;Melanoma;member;microscopic imaging;Molecular;Mus;Myeloid Cells;N-terminal;Natural Immunity;nucleic acid structure;Nucleic Acids;Organism;pathogen;pathogenic bacteria;pathogenic virus;Pathogenicity;Pathway interactions;Periodicity;Phase;Phenotype;Phosphoric Monoester Hydrolases;Phosphotransferases;Play;preference;Production;Property;Protein Dephosphorylation;Protein Phosphatase 2A Regulatory Subunit PR53;Proteins;receptor;receptor binding;recruit;Regulatory T-Lymphocyte;Relaxation;response;Role;Signal Pathway;Stimulator of Interferon Genes;Structure;Superhelical DNA;T-Lymphocyte;TBK1 gene;Testing;transcription factor;Transcriptional Activation;Viral

PROJECT_TITLE: Molecular and Functional Analysis of Innate Immune Receptors

STUDY_SECTION: III

STUDY_SECTION_NAME: Innate Immunity and Inflammation Study Section[III]


NIH_SPENDING_CATS: Bioengineering;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Rehabilitation;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Anterior cruciate ligament (ACL) injuries are a leading cause of training and sports-related injuries, resulting in significant loss of activity and quality of life. ACL reconstruction, a common treatment, requires suitable tendon graft-to-bone integration to resume prior activities, as such there is an unmet clinical need to improve and expedite treatment of these debilitating injuries to get patients back to their active lifestyles and minimize health care expenditures. This proposal seeks to address this clinical need by localizing delivery of a small molecule agonist of the hedgehog pathway, a potent regulator of fibrocartilage formation during enthesis development, to improve tendon-to-bone integration following anterior cruciate ligament reconstruction.

PI_NAMEs: DYMENT, NATHANIEL A. (contact);KUNTZ, ANDREW FREDERIC

PROGRAM_OFFICER_NAME: MARQUITZ, ARON

PROJECT_TERMS: active lifestyle;Address;Adult;Agonist;Animals;Anterior;Anterior Cruciate Ligament;anterior cruciate ligament injury;anterior cruciate ligament reconstruction;anterior cruciate ligament rupture;articular cartilage;Back;bone;bone healing;Bone Marrow;bone repair;Bromodeoxyuridine;Cell Proliferation;cell type;Cells;Clinical;Collagen Fiber;common treatment;Data;Development;Dose;Drug Delivery Systems;Erinaceidae;Failure;Femur;Fibrocartilages;Formulation;functional outcomes;functional restoration;Future;Genes;Genetic;Goals;graft failure;Growth and Development function;healing;Health;Health Expenditures;High Pressure Liquid Chromatography;Histology;Image;improved;In Vitro;in vivo;Injury;innovation;Investigation;Joints;Knee;Lasers;Ligaments;Long-Term Effects;Magnetic Resonance Imaging;Maintenance;Measures;Mechanics;Mesenchymal Stem Cells;mesenchymal stromal cell;Methods;Microspheres;mineralization;Modeling;Monitor;nanofiber;novel;novel therapeutic intervention;Operative Surgical Procedures;Oryctolagus cuniculus;Outcome;Pathway interactions;Patients;Pilot Projects;Positioning Attribute;premature;Process;Proliferating;Proteoglycan;Quality of life;Recovery;Recurrence;rehabilitation strategy;Rehabilitation therapy;repaired;Research;response;Risk;risk minimization;Role;scaffold;Site;small molecule;smoothened signaling pathway;Sports;standard of care;stem cell proliferation;stem cells;Synovial Membrane;System;targeted delivery;Technical Expertise;Techniques;tendon graft;Tendon structure;Testing;Therapeutic;therapeutic evaluation;therapy development;tibia;Tissues;Training;Translating;Traumatic Arthropathy

PROJECT_TITLE: Localized small molecule delivery to improve tendon-to-bone integration following anterior cruciate ligament reconstruction

STUDY_SECTION: MTE

STUDY_SECTION_NAME: Musculoskeletal Tissue Engineering Study Section[MTE]


ADMINISTERING_IC: MD

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Prevention;Social Determinants of Health;Suicide

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE Social support has multiple beneficial effects that mitigate adverse mental health outcomes and promote well- being across all populations. Understanding how to optimize social support for transgender and nonbinary (TNB) populations, specifically those experiencing multiple forms of marginalization, could meaningfully reduce TNB mental health disparities, specifically depression, anxiety, and suicide risk. Using an intersectional framework and a community-engaged approaches, this project will identify the most crucial aspects of social support for TNB populations for reducing adverse mental health outcomes, and to develop the measurement tools necessary to support future prevention and intervention strategies that can build and leverage social support to improve TNB mental health.

PI_NAMEs: BUDGE, STEPHANIE L;TEBBE, ELLIOT  (contact)

PROGRAM_OFFICER_NAME: BARKSDALE, CRYSTAL

PROJECT_TERMS: Address;Adult;Anxiety;anxiety reduction;Attitude;Buffers;Characteristics;cisgender;Clinical;Collaborations;Communities;community advisory board;community engaged approach;community engagement;community organizations;Data;design;Development;diaries;Dimensions;Disparity;Ecological momentary assessment;education resources;Emotional;Ethnic Origin;experience;Focus Groups;Future;Goals;Health;health determinants;health disparity;health inequalities;Health Promotion;Health Resources;HIV risk;improved;inattention;Individual;innovation;Institution;Intervention;Interview;Investigation;Knowledge;Link;Longitudinal Surveys;marginalization;Measurement;Measures;member;Mental Depression;Mental Health;Methods;minority stress;Modeling;National Institute on Minority Health and Health Disparities;Network-based;nonbinary;Outcome;Outcome Study;Participant;peer;people of color;Personal Satisfaction;Persons;physical conditioning;Population;Prevention strategy;protective factors;Protocols documentation;Psychometrics;Race;Research;Research Methodology;Resources;Risk;risk mitigation;Sampling;Scholarship;Self-Injurious Behavior;social;social contact;Social Network;social stigma;Social support;Societies;Source;Specificity;Statistical Models;Structure;Subgroup;substance use;suicidal;suicidal risk;Testing;theories;Time;tool;transgender;translational impact;Variant

PROJECT_TITLE: A multidimensional investigation of social support for transgender and nonbinary people and its impacts on health and well-being: Measurement development using community engagement

STUDY_SECTION: SPIP

STUDY_SECTION_NAME: Social Psychology, Personality and Interpersonal Processes Study Section[SPIP]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Breast Cancer;Cancer;Clinical Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Women's Health Research

PHR: PROJECT NARRATIVE Integrating tumor function-orientated imaging technology such as near-infrared tomographic optical breast imaging (TOBI) with predominantly structure-oriented clinical diagnostic imaging modalities has demonstrated considerable potential in improving the specificity of breast cancer diagnoses. This project seeks to address the limitation of optical breast imaging in characterizing small lesions by utilizing a deep learning-based image reconstruction framework accompanied by a dual-modal integration with diagnostic x-ray mammography under spot compression (DeepTOBIDx) to achieve marked improvement in optical image resolution, as well as in quantification accuracy and speed. Once validated in the proposed reader study, this work will offer radiologists with actionable lesion functional information to effectively avoid unnecessary biopsies during the diagnostic workup.

PI_NAMEs: DENG, BIN  (contact)

PROGRAM_OFFICER_NAME: PEREIRA DE SA, RUI CARLOS

PROJECT_TERMS: 3-Dimensional;accurate diagnosis;Address;Adopted;Anatomy;Anxiety;Back;Benchmarking;Benign;Biological Markers;Biological Models;Biopsy;Blinded;Breast;breast cancer diagnosis;Breast Cancer Patient;breast imaging;breast lesion;Case Study;Categories;Characteristics;Clinical;clinical application;clinical decision-making;clinical diagnostics;clinical imaging;clinical practice;cohort;Complex;Consumption;Data;data acquisition;Data Set;deep learning;deep learning model;deep neural network;demographics;density;design;detector;Diagnosis;Diagnostic;Diagnostic Imaging;Diagnostic X-Ray;Diameter;diffuse optical tomography;digital;Digital Breast Tomosynthesis;Engineering;Functional disorder;Functional Imaging;generative adversarial network;Geometry;Goals;Health Care Costs;Hemoglobin;high resolution imaging;Human;human-in-the-loop;Image;image reconstruction;Imaging Device;imaging modality;imaging system;Imaging technology;improved;Joints;Lesion;Location;Magnetic Resonance Imaging;Malignant - descriptor;Malignant Breast Neoplasm;Malignant Neoplasms;Mammography;Maps;Measurement;Methods;Modality;Modification;mortality;Multimodal Imaging;multimodal modeling;multimodality;Neural Network Simulation;next generation;Noise;novel;optical imaging;Optical Tomography;Optics;Outcome;Patient-Focused Outcomes;Patients;Physiological;Population;Predictive Value;Procedures;programs;prospective;Prospective cohort;radiologist;Reader;Reading;Recovery;Research;Resolution;Risk;sensor;Source;Specificity;Speed;Spottings;standard of care;Structural defect;Structure;System;Technology;Testing;Thick;Time;Tissues;tomography;Training;training data;translational barrier;transmission process;tumor;ultrasound;Unnecessary Procedures;Work

PROJECT_TITLE: DeepTOBIDx: deep learning-enhanced multimodal diagnostic breast imaging

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]


NIH_SPENDING_CATS: Aging;Bioengineering;Biomedical Imaging;Clinical Research;Clinical Trials and Supportive Activities

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

PHR: Validation of NAD+ measurements for human clinical studies: multi-method inter-laboratory standardization There is widespread interest in the role of NAD+ in human disease and whether increasing NAD+ with supplements (e.g., nicotinamide riboside or nicotinamide mononucleotide) has therapeutic value in humans. However, our understanding of NAD+ and its metabolites in vivo is limited by technical barriers and a lack of consensus on analytical techniques. This proposal will develop standard methodology that can be used to measure NAD+ and related metabolites in human clinical trials. This includes testing whether simple blood and urine measurements by mass spectrometry or enzymatic assays can accurately predict the NAD+ content of tissue, which is currently determined by expensive and technically challenging magnetic resonance spectroscopy (MRS) methods.

PI_NAMEs: BAUR, JOSEPH A.;MESAROS, A. CLEMENTINA ;REDDY, RAVINDER  (contact)

PROGRAM_OFFICER_NAME: SAZONOVA, IRINA Y

PROJECT_TERMS: age group;Agreement;Binding Proteins;Biochemical;Biological Assay;Biopsy;Blood;Body Fluids;Brain;Buffers;Calibration;Cells;Chemicals;Clinical;Clinical Data;Clinical Research;Clinical Trials;Consensus;Deuterium;Diphosphates;efficacy evaluation;experimental group;Freezing;Healthcare;Human;human disease;human subject;human tissue;in vivo;Individual;interest;Intervention;Isotopes;Knowledge;Laboratories;liquid chromatography mass spectrometry;Magnetic Resonance Spectroscopy;Masks;Mass Spectrum Analysis;Measurement;Measures;Metabolism;metabolomics;method development;Methodology;Methods;multidisciplinary;Muscle;NADH;NADP;Nicotinamide Mononucleotide;nicotinamide-beta-riboside;Noise;novel;Nuclear Magnetic Resonance;Older Population;Physiological;practical application;recruit;Rest;Role;Route;Sampling;Serum;sex;Signal Transduction;Site;Standardization;stress state;Supplementation;Surrogate Markers;Techniques;Temperature;Testing;Therapeutic;Time;Tissues;Urine;Validation;Whole Blood;Work

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-2 (M1)]


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Bioengineering;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Hematology;Infectious Diseases;Lung;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Racial and Ethnic Minority Health Research;Rare Diseases;Sepsis;Social Determinants of Health

PHR: Project Narrative In-hospital mortality prediction models (MPMs) are widely used in clinical research and practice; but existing MPMs suffer from algorithmic bias, or systematic differences in performance across groups, which is especially consequential for patients hospitalized with acute respiratory failure (ARF) or sepsis because (1) such patients face high risks of biased predictions due to diagnostic uncertainty and high mortality risk; (2) these syndromes pose increased mortality risks for racial and ethnic minorities; and (3) MPMs are frequently applied to these populations. Therefore, we seek to develop, validate, and demonstrate the impact of a novel MPM that optimizes fairness (i.e., defined by ‘groupwise optimality,’ optimizing subgroup performance without sacrificing predictive accuracy) across key subgroups defined by race, ethnicity, sex, age, primary language, insurance status, and social vulnerability. Unlike development of commonly used MPMs, we will explicitly address key causes of bias in model development: differential missing data and calibration biases.

PI_NAMEs: KOHN, RACHEL  (contact)

PROGRAM_OFFICER_NAME: SHENOY, SIDDHARTH KAUP

PROJECT_TERMS: Accident and Emergency department;Acute;Acute respiratory failure;Address;Administrator;Admission activity;Advocate;Age;algorithmic bias;Algorithms;Beds;black patient;Blinded;Calibration;California;Characteristics;Clinical;clinical practice;clinical predictors;Clinical Research;cohort;Collaborations;COVID-19;Data;data integration;Deterioration;Development;Diagnostic;disability;Elasticity;Electronic Health Record;electronic structure;Eligibility Determination;Ensure;Equity;ethnic minority;Ethnic Origin;Exclusion;Exercise Therapy;Face;feature selection;Focus Groups;Geography;Goals;Health;health care disparity;health equity;Health system;high risk;Hospital Mortality;Hospitalization;Hospitals;Hour;improved;indexing;Informatics;innovation;Insurance Coverage;Intensive Care Units;Laboratories;Language;Logistics;machine learning model;Measures;minority patient;model development;Modeling;mortality;mortality risk;National Heart, Lung, and Blood Institute;neuromuscular;novel;Organ failure;Outcome;Patient Admission;patient subsets;Patients;Pennsylvania;Performance;Physiology;Population;pragmatic trial;Predictive Analytics;predictive modeling;preference;Public Health;Race;racial minority;random forest;Recording of previous events;Research Personnel;Resource Allocation;Risk Adjustment;Sepsis;septic patients;sex;simulation;social vulnerability;sociodemographics;structured data;Subgroup;Syndrome;Testing;Therapeutic Studies;Tidal Volume;Uncertainty;Universities;ventilation;Work

PROJECT_TITLE: Promoting algorithmic equity in in-hospital mortality prediction

STUDY_SECTION: CIDH

STUDY_SECTION_NAME: Clinical Informatics and Digital Health Study Section[CIDH]


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Hepatitis;Hepatitis - B;Infectious Diseases;Liver Disease

ORG_CITY: Princeton

ORG_NAME: PRINCETON UNIVERSITY

PHR: Public health narrative: Hepatitis B virus (HBV) remains a major health problem, globally affecting at least 257 million carriers who are at risk of developing serious liver disease, including liver cancer. Although HBV infections can be prevented through vaccination, chronic hepatitis B can rarely be cured. Here, we aim to mechanistically dissect the steps of the HBV life-cycle that are critical for persistence and could yield new targets for novel antiviral therapies.

PI_NAMEs: PLOSS, ALEXANDER  (contact)

PROGRAM_OFFICER_NAME: FLORES, AMANDA CHRISTINE

PROJECT_TERMS: Affect;Animal Model;Anti-viral Therapy;Antibodies;Biochemical;Biological Assay;Biological Models;Cell Culture Techniques;Cell Extracts;Cell Line;Cell Nucleus;Cells;Cessation of life;Chronic;Chronic Hepatitis B;Circular DNA;Clustered Regularly Interspaced Short Palindromic Repeats;Coculture Techniques;Complex;cytotoxicity;Data;design;DNA lesion;DNA Ligases;DNA Polymerase III;DNA Repair;experience;Exposure to;Generations;Genetic;Genome;Goals;Health;Hepatitis B Virus;Hepatocyte;hepatoma cell;HepG2;high risk;Homologous Gene;Human;In Vitro;Individual;Infection;innovation;Integration Host Factors;Kinetics;knock-down;Knock-out;Learning;Lesion;Life Cycle Stages;Liver;Liver diseases;Maintenance;Malignant neoplasm of liver;Mediating;Methods;Molecular;Monitor;mouse model;Mus;Mutation;Nature;new therapeutic target;novel;overexpression;Pan Genus;pathogenic virus;Patients;Persons;Physiological;Polymerase;prevent;Process;Public Health;purge;Recombinants;reconstitution;Refractory;Regimen;Relaxation;repair enzyme;repaired;replication factor C;Resolution;Risk;Role;RTH-1 Nuclease;self assembly;Series;Set protein;small hairpin RNA;System;Techniques;Testing;Therapeutic Intervention;Transcript;Vaccination;Viral;Viral Genome;Virion;Virus;Virus Diseases;Virus Receptors;Work;Yeasts

PROJECT_TITLE: Mechanisms of hepatitis B virus cccDNA formation

STUDY_SECTION: VIRB

STUDY_SECTION_NAME: Virology - B Study Section[VIRB]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Eye Disease and Disorders of Vision;Neurosciences

ORG_DEPT: NEUROSCIENCES

PHR: PROJECT NARRATIVE The proposed work is basic research, designed to provide new insights into how a healthy nervous system implements decision rules that support flexible visuo-oculomotor behavior. Because the cortico-basal ganglia pathway has been implicated in multiple deficits associated with decision-making in Parkinsonism, addiction, and other disorders, our systematic examination of multiple key stations in this pathway is likely to provide health- related benefits in the long term.

PI_NAMEs: DING, LONG  (contact);GOLD, JOSHUA I

PROGRAM_OFFICER_NAME: FLANDERS, MARTHA C

PROJECT_TERMS: addiction;Basal Ganglia;Basic Science;Behavior;Behavioral;Binding;Brain;Brain region;Calibration;Cell Nucleus;Cognition;Data;Decision Making;Decision Modeling;design;discrimination task;Disease;electrical microstimulation;Face Processing;Feedback;Fiber;flexibility;Foundations;frontal eye fields;Functional disorder;Ganglia;Goals;Health;Impaired cognition;Impairment;information processing;innovation;insight;lateral intraparietal area;Link;Measurement;Measures;Modeling;Monkeys;Morphologic artifacts;Motor;Nervous System;neural;neural correlate;neuromechanism;Neurons;neurotransmission;novel;oculomotor;oculomotor behavior;Outcome;Output;Parietal Lobe;Parkinsonian Disorders;Pathway interactions;Pattern;Physiologic pulse;Prefrontal Cortex;Primates;Process;Property;Recording of previous events;response;Role;Saccades;Sensory;Site;Solid;Specific qualifier value;Structure;Substantia nigra structure;superior colliculus Corpora quadrigemina;Testing;theories;Time;Training;Update;Visual;Visual Motion;visual processing;visual stimulus;Work

PROJECT_TITLE: Neural mechanisms of flexible visual-oculomotor decision rules

STUDY_SECTION: NBVP

STUDY_SECTION_NAME: Neuroscience of Basic Visual Processes Study Section[NBVP]


ADMINISTERING_IC: GM

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: ITHACA

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: CORNELL UNIVERSITY

PHR: Project Narrative Peptide-based degraders can catalyze the selective degradation of a protein of interest but studies into their catalytic performance have been limited by their poor cellular permeability. By overcoming their cellular transport limitations, we will explore structure-function relationships to improve their potency and expand their use broadly as novel chemical biology tools and therapeutic modalities.

PI_NAMEs: ALABI, CHRISTOPHER AKINLEYE (contact)

PROGRAM_OFFICER_NAME: PHILLIPS, ANDRE W

PROJECT_TITLE: Optimizing PepTAC structure and amphiphilicity for enhanced target protein degradation

STUDY_SECTION: DBTD

STUDY_SECTION_NAME: Drug and Biologic Therapeutic Delivery Study Section[DBTD]


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Aging;Cancer;Cardiovascular;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Pediatric;Pediatric Cancer;Prevention;Rare Diseases;Social Determinants of Health

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: NARRATIVE Survivors of adolescent and young adult (AYA) cancer are likely to live several more decades, yet their previous treatment exposures can have dramatic long-term effects on their cardiovascular health. Our preliminary research suggests that there is a group of survivors of AYA cancer whose hearts are functioning at the same levels as hearts in individuals who are decades older. We have initiated the development of a diverse survivor of AYA cancer study designed to identify the characteristics of accelerated cardiac aging that can inform strategies reduce risk during treatment and develop personalized risk-informed follow-up care to reduce and prevent the development of cardiac dysfunction.

PI_NAMEs: HILDEBRANDT, MICHELLE A T (contact)

PROGRAM_OFFICER_NAME: GALLICCHIO, LISA M

PROJECT_TERMS: Acceleration;Address;Adolescent and Young Adult;Adolescent and young adult cancer patients;age acceleration;aged;Aging;aging biomarker;aging related;Anthracycline;Biodiversity;biological age;Biological Markers;Cancer Survivor;cancer therapy;Cardiac;cardiac aging;Cardiotoxicity;Cardiovascular Diagnostic Techniques;cardiovascular disorder risk;cardiovascular health;cardiovascular risk factor;Cardiovascular system;Caring;Characteristics;Chemotherapy and/or radiation;Clinical;cohort;comorbidity;Data;demographics;design;Development;Diagnosis;Disparity;Echocardiography;epigenetic clock;Ethnic Origin;Event;Exhibits;expectation;Exposure to;follow-up;Functional disorder;Genetic;Germ Lines;Health;Heart;heart function;Incidence;Individual;Investigation;Late Effects;Length;Life;Long-Term Effects;Lymphocyte;Malignant Neoplasms;Measures;Methylation;Modality;Morbidity - disease rate;mortality risk;Myocardial dysfunction;Neighborhoods;novel;Participant;patient population;Patients;Personal Satisfaction;Pharmaceutical Preparations;Phenotype;polygenic risk score;Population;prevent;Race;racial difference;Radiation;Research;Research Design;Risk;Risk Factors;Risk Reduction;Role;social health determinants;Survival Rate;Survivors;telomere;Testing;Treatment Protocols

PROJECT_TITLE: Role of disparities and aging biomarkers in accelerated cardiac aging among adolescent and young adult cancer survivors

STUDY_SECTION: BMCD

STUDY_SECTION_NAME: Basic Mechanisms of Cancer Health Disparities Study Section[BMCD]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Neurosciences;Substance Misuse

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Alcohol Use Disorder (AUD) is associated with deficits in brain structure and function, but it remains unclear which of these brain abnormalities can recover when alcohol use stops. This proposal aims to fill a gap in understanding how the neural mechanisms associated with cognitive reappraisal (e.g., prefrontal cortex [PFC]) and alcohol cue reactivity (e.g., striatum) change during early abstinence, and whether changes in these mechanisms can predict the individuals most likely to return to heavy alcohol use. By identifying neural signatures associated with risk for relapse to heavy drinking, we can target specific deficits and tailor treatment plans to each individual, improving outcomes for patients with AUD.

PI_NAMEs: GOWIN, JOSHUA LEIGH (contact)

PROGRAM_OFFICER_NAME: GRAKALIC, IVANA

PROJECT_TERMS: Abstinence;Admission activity;Adult;Affect;aged;Alcohol consumption;alcohol cue;alcohol use disorder;Alcoholic beverage heavy drinker;Amygdaloid structure;Behavioral;Biological;Brain;brain abnormalities;Cessation of life;Chronic;cognitive function;cognitive reappraisal;Cognitive Therapy;Coping Skills;Corpus striatum structure;Country;craving;cue reactivity;drinking;emotion regulation;Emotional;emotional functioning;Ensure;evidence base;Exercise;follow-up;Frequencies;Functional Magnetic Resonance Imaging;Future;Group Therapy;Heavy Drinking;Hispanic-serving Institution;Impairment;improved;improved outcome;Individual;individualized medicine;insight;Insurance;Link;machine learning algorithm;Measures;Medicaid;mindfulness;Modeling;Morbidity - disease rate;mortality;Motivation;neural;neuroimaging;neuromechanism;Neurophysiology - biologic function;Outpatients;Participant;Patient Self-Report;Patient-Focused Outcomes;Patients;Pattern;Pharmaceutical Preparations;Population;Population Heterogeneity;Prefrontal Cortex;Process;programs;prospective;psychoeducation;Quality of Care;recruit;Relapse;relapse risk;Research;Residential Treatment;response;Risk;Sampling;Social Functioning;standard care;Stimulus;Structure;substance use treatment;success;Symptoms;Techniques;Testing;therapeutic target;treatment center;treatment planning;Ventral Tegmental Area

PROJECT_TITLE: Neural Signature Changes Across Early Abstinence in Alcohol Use Disorder

STUDY_SECTION: ARM

STUDY_SECTION_NAME: Addiction Risks and Mechanisms Study Section[ARM]


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: NARRATIVE While electronic health records (EHRs) have had positive effects for patient safety and quality of care, they have also worsened the work experiences of primary care physicians (PCPs), and health system leaders struggle to identify interventions that contribute to improved primary care quality while also enhancing PCPs’ EHR interactions and wellbeing. To address this gap, we will use data from both community-based and academic primary care practices to evaluate the impact of three EHR-optimization interventions - 1) scribes, 2) advanced team-based inbox messaging support, and 3) artificial intelligence (AI)-assisted inbox messaging support - on PCP and patient panel outcomes and will assess the cost effectiveness of these interventions. The results of this study will guide health systems leaders towards interventions that both address EHR-based challenges negatively impacting the PCP work experience and maximize benefits of EHRs for physicians, patients, and health systems.

PI_NAMEs: BATES, DAVID W., MD,MSC (contact);ROTENSTEIN, LISA

PROGRAM_OFFICER_NAME: EDEN, AIMEE

PROJECT_TITLE: Assessing the Effects of EHR Optimization Interventions in Primary Care

STUDY_SECTION: HITR

STUDY_SECTION_NAME: Healthcare Information Technology Research[HITR]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Dissemination and Implementation Research;Drug Abuse (NIDA only);Fentanyl Misuse and Addiction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Opioid Misuse and Addiction;Opioids;Patient Safety;Physical Injury - Accidents and Adverse Effects;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

ORG_CITY: RICHMOND

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

PHR: Project Narrative To better understand the needs and barriers faced by adults with SUD in underserved, high-poverty communities in Richmond, VA, the Virginia Patient Engagement Resource Center (PERC) will create and train a patient advisory panel with people in recovery and peer recovery navigators. We will implement a consultation process co-developed with the panel to facilitate discussions with researchers regarding their grant proposals, ongoing research projects, and/or emerging research outcomes. We will conduct research on patient experiences, including a survey of individuals not yet in recovery and qualitative and participatory, arts- based research, and use the findings to inform the design and implementation of two pilot research projects strategically focused on increasing treatment initiation and retention.

PI_NAMEs: ZIMMERMAN, EMILY BETH (contact)

PROGRAM_OFFICER_NAME: FITZ-RANDOLPH, MARCY ESTHER

PROJECT_TERMS: addiction;Address;Adopted;Adult;African American;African American population;Applications Grants;Articulation;care delivery;Cessation of life;Collaborations;collaborative approach;Communication;community based participatory approach;community engagement;Consultations;cost;Criminal Justice;Data;Data Collection;Data Sources;design;Diagnosis;Disadvantaged;Discrimination;Disparity;dissemination research;dissemination strategy;Drug Prescriptions;Education;empowerment;Equity;Evaluation;evidence base;Exclusion;experience;Fatality rate;Fentanyl;Fostering;Fright;Glean;Goals;Guns;Health;Health Care Costs;Health system;Healthcare;illicit drug use;Illicit Drugs;implementation research;improved;Individual;insight;intersectionality;Intervention;Interview;Latino;Link;Literature;Low income;marginalization;marginalized population;medication for opioid use disorder;member;Methodology;Modification;mortality;Motor Vehicles;Opioid;opioid mortality;opioid overdose;opioid use;opioid use disorder;Outcomes Research;Overdose;overdose death;Participant;patient engagement;Patients;peer;peer recovery;Persons;Pharmaceutical Preparations;Phase;Pilot Projects;poor communities;Population;Primary Care;Process;Productivity;productivity loss;programs;racial disparity;Readiness;Recovery;Research;Research Personnel;Research Project Grants;Resources;retention rate;service delivery;Services;social stigma;Socioeconomic Status;Structure;Subgroup;substance abuse treatment;substance use;Substance Use Disorder;Surveys;Testing;Training;treatment program;user centered design;Variant;Virginia;Vulnerable Populations

PROJECT_TITLE: A Virginia Patient Engagement Resource Center to Improve Substance Abuse Treatment Interventions

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 SAI-E (M1)]


NIH_SPENDING_CATS: Diabetes;Digestive Diseases;Genetics

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: Narrative  Type 3c diabetes mellitus (T3cD) accompanies exocrine pancreas diseases like chronic pancreatitis (CP) and has distinct clinical features and greater prevalence than previously appreciated, but the mechanisms underlying T3cD are poorly understood. From studies of islets in living subjects with CP, we have identified molecular and functional changes in islet cells that could promote prediabetes. In this proposal we aim to identify signaling and genetic mechanisms underlying islet dysfunction in pre-T3cD development.

PI_NAMEs: KIM, SEUNG K (contact);MACDONALD, PATRICK

PROGRAM_OFFICER_NAME: ZAGHLOUL, NORANN

PROJECT_TERMS: acute pancreatitis;Address;Alpha Cell;Anti-Inflammatory Agents;Atrophic;Biological Assay;Biology;biomarker identification;Cell Physiology;Cells;Chromatin;chronic pancreatitis;Clinical;Clinical Research;Consensus;Cystic Fibrosis;cytokine;Data;Detection;Development;Diabetes Mellitus;Diagnosis;Disease;Electrophysiology (science);Exocrine pancreas;Fibrosis;Functional disorder;gastric inhibitory polypeptide receptor;Gene Expression;Gene Expression Regulation;gene function;Genetic;Glucagon;Human;human tissue;hyperglucagonemia;Hyperglycemia;imaging modality;impaired glucose tolerance;Impairment;In Vitro;Inflammatory;innovation;Insulin;Insulin-Dependent Diabetes Mellitus;Interleukin-10;islet;Islet Cell;Islets of Langerhans;Islets of Langerhans Transplantation;Knowledge;Laboratories;Ligands;Link;Methods;Modernization;Molecular;molecular phenotype;multiplexed imaging;Non-Insulin-Dependent Diabetes Mellitus;Operative Surgical Procedures;Output;Pancreas;Pancreatic Diseases;Pancreatic Ductal Adenocarcinoma;patch clamp;Pathogenesis;Patients;Phenotype;Population;Prediabetes syndrome;Prevalence;Productivity;prospective test;receptor;reconstitution;Regulation;Research;Risk Assessment;Sampling;Scientist;Signal Pathway;Signal Transduction;Signaling Protein;single cell ATAC-seq;single cell technology;Testing;Therapeutic;Tissue Procurements;Tissues;tool;Total Pancreatectomy;transcriptomics;type I and type II diabetes;Work

PROJECT_TITLE: Investigating mechanisms underlying diabetes associated with exocrine pancreas diseases

STUDY_SECTION: CSME

STUDY_SECTION_NAME: Cell Signaling and Molecular Endocrinology Study Section[CSME]


NIH_SPENDING_CATS: Neurosciences

ORG_CITY: ANN ARBOR

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: Project Narrative Acetylcholine is a neurotransmitter that plays critical roles in normal hearing, helping us hear in quiet or noisy environments throughout our lives. Understanding these roles is critical for developing approaches to help people with age-related hearing loss, difficulty understanding speech in noisy environments, learning to hear with cochlear implants or coping with hearing dysfunctions in disorders such as autism or schizophrenia. The present proposal will answer critical questions about the cellular and circuit mechanisms that allow acetylcholine to support hearing.

PI_NAMEs: ROBERTS, MICHAEL THOMAS (contact)

PROGRAM_OFFICER_NAME: POREMBA, AMY

PROJECT_TERMS: Acetylcholine;Address;Aging;Architecture;Arousal;Auditory;auditory processing;auditory stimulus;Auditory system;autism spectrum disorder;awake;Axon;Behavioral;Brain;Brain Stem;Cell Nucleus;Central Auditory Processing Disorder;cholinergic;Cholinergic Agents;cholinergic neuron;Cholinergic Receptors;cholinergic synapse;Cochlear Implants;Complex;coping;Cues;Data;differential expression;Disease;Dorsal;Electron Microscopy;Environment;Equilibrium;experimental study;flexibility;Fluorescent in Situ Hybridization;Future;Genetic Techniques;Goals;Hearing;hearing impairment;Image;in vivo;Inferior Colliculus;insight;Investigation;Knowledge;Label;Learning;Link;Location;Logic;Maps;Mediating;Midbrain structure;Molecular Genetics;Mus;Muscarinic Acetylcholine Receptor;Muscarinics;Neurons;Neurotransmitters;Nicotinic Receptors;normal hearing;novel;optogenetics;patch clamp;Pathway interactions;pedunculopontine tegmentum;Persons;Pharmacology;Physiology;Play;Population;Positioning Attribute;Presbycusis;Presynaptic Terminals;Prosencephalon;receptive field;receptor;Receptor Activation;response;Response Latencies;Rewards;Role;Schizophrenia;Sensory;sensory stimulus;Signal Transduction;sound;Source;Speech;Speed;Synapses;System;Testing;transmission process;two-photon;Whole-Cell Recordings

PROJECT_TITLE: Mechanisms of Cholinergic Signaling in the Inferior Colliculus

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Aging;Arthritis;Chronic Pain;Dental, Oral, and Craniofacial Disease;Genetics;Human Genome;Neurosciences;Osteoarthritis;Pain Research;Temporomandibular Muscle/Joint Disorder (TMJD)

ORG_CITY: Los Angeles

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: PROJECT NARRATIVE Temporomandibular joint (TMJ) osteoarthritis (TMJOA) can cause joint degeneration and chronic pain, and has no effective treatments. This study will establish a high dimensional map of TMJ with or without OA at single cell and 3-D resolutions and validate Netrin-1/Dcc as a new therapeutic target for TMJOA.

PI_NAMEs: CHEN, JIANFU  (contact)

PROGRAM_OFFICER_NAME: GHIM, MELISSA M

PROJECT_TERMS: 3-Dimensional;Adopted;Affect;afferent nerve;Afferent Neurons;Arthralgia;ATAC-seq;Atlases;Automobile Driving;Axon;axon growth;axon guidance;Behavior;Biological Assay;Biology;Cell Communication;Cell Nucleus;cell type;Cells;Chondrocytes;Chromatin;Chronic;chronic pain;Clinical;Coculture Techniques;connectome;craniofacial;Data;Degenerative polyarthritis;Dependence;Development;Disease;effective therapy;Epigenetic Process;epigenomics;Fibroblasts;Foundations;Freund's Adjuvant;Gene Expression;Generations;Genetic;genome wide association study;Goals;Growth;high dimensionality;Human;Hyperactivity;Hyperalgesia;Image;imaging modality;Imaging technology;In Vitro;in vivo;Individual;Inflammation;Inflammatory;insight;joint destruction;Joints;Ligands;Maps;mechanical load;Mediating;Mediator;Methodology;Modeling;Molecular;mouse genetics;mouse model;multimodality;multiple omics;Mus;Nerve;nerve supply;neural;neural circuit;neuronal growth;Neurons;Neurosciences;new therapeutic target;Nociception;NTN1 gene;Opioid;opioid exposure;Orofacial Pain;osteoarthritis pain;Osteoclasts;Osteocytes;Pain;pain behavior;Pathology;Patients;Population;Positioning Attribute;Publishing;receptor;Research Personnel;Resolution;risk variant;Sensory;single nucleus RNA-sequencing;single-cell RNA sequencing;skills;Solvents;Structure of trigeminal ganglion;Synovial Fluid;System;Temporomandibular Joint;Temporomandibular joint osteoarthritis;Testing;therapeutic target;Three-Dimensional Imaging;transcriptome;transcriptomics;Work

PROJECT_TITLE: Mapping temporomandibular joint (TMJ) degeneration and pain

STUDY_SECTION: SBSR

STUDY_SECTION_NAME: Skeletal Biology Structure and Regeneration Study Section[SBSR]


NIH_SPENDING_CATS: Brain Disorders;Chronic Liver Disease and Cirrhosis;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Liver Disease;Microbiome;Neurodegenerative;Rare Diseases

PHR: Project Narrative One-third of patients with cirrhosis will develop a complication called hepatic encephalopathy, which is characterized by confusion, fatigue, and personality changes – all of which significantly decrease quality of life and patient survival. Current treatments are only moderately effective, but there is some data suggesting that intestinal bacteria may play an important role in causing hepatic encephalopathy. This project uses novel approaches to identify the importance of intestinal bacteria in hepatic encephalopathy, and tests if treatments that influence intestinal bacteria can treat this condition.

PI_NAMEs: BLOOM, PATRICIA PRINGLE (contact)

PROGRAM_OFFICER_NAME: LOH, KATRINA SHUEH WEN

PROJECT_TERMS: Address;Ammonia;Applications Grants;Bacteria;bacterial community;Bacterial Translocation;Biological;Biopsy;Brain;Bypass;Cirrhosis;Clinical;clinical care;Clinical Investigator;clinical practice;clinical predictors;clinical translation;Clinical Trials;Clinical Trials Design;Cognitive;cognitive function;Complication;Confusion;Data;design;Diarrhea;efficacy evaluation;Electrical Resistance;Endoscopy;Enrollment;Fatigue;fecal transplantation;Feces;Funding;Future;Goals;Group Meetings;gut bacteria;Hepatic Encephalopathy;high risk;High-dimensional Modeling;hospitalization rates;Impairment;improved;insight;intestinal barrier;Intestinal permeability;Intestines;K-Series Research Career Programs;Knowledge acquisition;Lactulose;Lead;Learning;Liver;Mentored Patient-Oriented Research Career Development Award;Mentorship;metabolome;metabolomics;metagenomic sequencing;Microbe;microbial;microbiome;microbiome composition;microbiome sequencing;microbiota;Modeling;mortality;motor disorder;Mucous Membrane;multiple omics;next generation;novel strategies;novel therapeutics;Osmosis;Pathogenesis;Pathway interactions;Patients;Personality;Persons;Pharmaceutical Preparations;Play;Polyethylene Glycols;Potato;prebiotics;Prevalence;prevent;primary outcome;Production;prospective;Prospective, cohort study;protein expression;psychologic;Psychometrics;Public Health;Quality of life;Randomized;Recording of previous events;Research;Research Design;Research Personnel;Role;side effect;skills;standard of care;Starch;Statistical Models;symposium;Symptoms;Systems Biology;targeted treatment;Testing;Therapeutic;Tight Junctions;Training;translational scientist;United States;Venous;Volatile Fatty Acids;Work

PROJECT_TITLE: The role of the microbiome in hepatic encephalopathy pathogenesis and treatment

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Infectious Diseases;Prevention

ORG_CITY: ATLANTA

ORG_DEPT: PEDIATRICS

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative Infections due to antibiotic-resistant bacteria known as Enterobacterales are occurring increasingly in the community in otherwise healthy persons without significant prior health care contact. Our goal is to identify community-based exposures to resistant bacteria by examining potential environmental, animal, and household sources. Our results will lead to ways to control the sources that we find and to decrease the risk of antibiotic- resistant bacterial infections in the community.

PI_NAMEs: LOGAN, LATANIA K. (contact)

PROGRAM_OFFICER_NAME: ERNST, NANCY L

PROJECT_TERMS: Adult;Animals;Antibiotic Resistance;Antibiotics;Antimicrobial Resistance;Area;Bacteria;Bacterial Antibiotic Resistance;Bacterial Infections;bacterial resistance;Base Sequence;beta-Lactamase;Chicago;Child;Childhood;Clinical;clinically relevant;colistin resistance;Communities;community transmission;Community-Acquired Infections;companion animal;comparison control;cost;Cyclophosphamide;Data;Dimensions;Effectiveness;Environment;Epidemic;epidemiologic data;Epidemiology;Escherichia coli;exposure reduction interventions;Exposure to;Extended-spectrum β-lactamase;Farm;fluoroquinolone resistance;genomic data;Genotype;Goals;Health Care Costs;health care settings;Healthcare;healthcare-associated infections;high risk;Home;Hospitalization;Household;Human;Individual;Infection;infection risk;Interruption;Intestines;Knowledge;Lactamase;Length of Stay;Livestock;Location;Mediating;member;Metagenomics;Mobile Genetic Elements;Multi-Drug Resistance;National Institute of Allergy and Infectious Disease;Outcome;Pathway interactions;Pattern;Persons;Plants;Plasmids;Predisposition;prevent;Public Health;Recreation;Reporting;Research;residence;Resistance;resistance gene;Risk;Risk Assessment;Risk Factors;Role;Sampling;Source;Stream;Surface;Surveys;Taxonomy;transmission process;Update;Virulent;whole genome;Work

PROJECT_TITLE: Community Reservoirs of Extended-Spectrum Beta-Lactamase-producing and Multi-Drug Resistant Enterobacterales

STUDY_SECTION: PRID

STUDY_SECTION_NAME: Population based Research in Infectious Disease Study Section[PRID]


NIH_SPENDING_CATS: Cancer;Prevention

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: The fundamental chemical research provided by the Core Specialist at the service of biology and medicine, if funded, would ultimately contribute to the knowledge of cancer genesis, detection, prevention, and treatment. The synergy stemming from the combination of chemical expertise with high level biology is bound to provide better understanding of disease and better treatment. The close proximity between chemists, biologists and clinicians within the nurturing and collaborative environment that is offered by MSK and WCM are a sure guaranty for success.

PI_NAMEs: OUERFELLI, OUATHEK  (contact)

PROGRAM_OFFICER_NAME: FU, YALI

PROJECT_TERMS: Agreement;Alopecia;Binding;Biology;Cancer Detection;chemical synthesis;Chemicals;Chemistry;Collaborations;collaborative environment;Communities;Core Facility;Detection;Development;Disease;FDA approved;Funding;Human Resources;inter-institutional;Knowledge;Leadership;Malignant Neoplasms;medical schools;Medicine;Memorial Sloan-Kettering Cancer Center;NCI Center for Cancer Research;Organic Synthesis;Pharmaceutical Chemistry;Pharmaceutical Preparations;preclinical study;Prevention;Research;Research Personnel;Services;Specialist;stem;success;synergism;Therapeutic Agents;tool;Topical application

PROJECT_TITLE: Organic Synthesis at the Service of Biology and Medicine

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-1 (M2)]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Genetics;Ovarian Cancer;Rare Diseases;Women's Health Research

ORG_NAME: RESEARCH INST OF FOX CHASE CAN CTR

PHR: PROJECT NARRATIVE There are approximately 55,000 deaths from breast and ovarian cancer annually in the United States, with BRCA1 and BRCA2 mutations found in 5-7% of breast and 6-15% of ovarian cancers cases. PARP inhibitor therapies extend the lives of BRCA1/2 mutation carrying patients; however, drug resistance invariably emerges. The goal of this project is to identify new biological factors that determine PARP inhibitor sensitivity.

PI_NAMEs: JOHNSON, NEIL  (contact)

PROGRAM_OFFICER_NAME: WITKIN, KEREN L

PROJECT_TERMS: Binding;Biological Factors;Biological Models;BRCA mutations;BRCA1 gene;BRCA1 Mutation;BRCA2 gene;BRCA2 Mutation;Breast;Cancer Model;Cancer Patient;Cell Line;cell type;Cessation of life;chemotherapy;Chromatin;Clinical;Collection;CRISPR screen;Development;DNA;DNA Damage;DNA Repair;DNA Repair Pathway;Drug resistance;Event;Excision;Filament;Future;gene function;Gene Mutation;Genes;genome integrity;Goals;Homo;homologous recombination;Human;in vivo;inhibitor therapy;insight;Knowledge;loss of function;Maintenance;Malignant Breast Neoplasm;Malignant neoplasm of ovary;Malignant Neoplasms;Molecular;mouse model;mutant;mutant mouse model;Mutate;Mutation;novel;Outcome;PALB2 gene;Pathway interactions;patient derived xenograft model;Patients;Poly(ADP-ribose) Polymerase Inhibitor;pre-clinical;Proteins;recombinase;recruit;Reporting;Research;Resistance;Resistance development;response;restoration;Role;Single-Stranded DNA;Site;therapeutically effective;Transgenic Mice;treatment response;United States;whole genome;Work

PROJECT_TITLE: Compensatory Mechanisms that Promote Homologous Recombination in BRCA1 Mutant Cancers

STUDY_SECTION: BCO

STUDY_SECTION_NAME: Biochemical and Cellular Oncogenesis Study Section[BCO]


NIH_SPENDING_CATS: Bioengineering;Cancer;Orphan Drug;Pediatric;Pediatric Cancer;Radiation Oncology;Rare Diseases

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Metastatic osteosarcoma (OS) in people and dogs is almost uniformly fatal with little advances in treatment in the past four decades. Alpha-emitter therapy offers a targeted means to treat metastatic OS and is impervious to treatment resistance often seen with chemotherapy, radiation therapy, and immunotherapy. Using a spontaneously occurring canine OS in client-owned pets, we will investigate the efficacy and toxicity of alpha- emitter therapy in a real-world model for future translation to human OS patients.

PI_NAMEs: KRAITCHMAN, DARA L;SGOUROS, GEORGE  (contact)

PROGRAM_OFFICER_NAME: CAPALA, JACEK

PROJECT_TERMS: absorption;Actinium;Acute;acute toxicity;Adolescence;Aftercare;Alpha Particle Emitter;Alpha Particles;Animal Model;Antibodies;antibody conjugate;Biological Assay;Biopsy;calcification;cancer therapy;cancer type;Canis familiaris;chemotherapy;Client;Clinical;Complete Blood Count;Creatinine;Data;Diagnosis;Disease;DNA;DNA Double Strand Break;Dose;Dose Limiting;Dose Rate;dosimetry;Drug Kinetics;efficacy evaluation;Evaluation;experimental study;Face;Friends;Future;Ganglioside GD2;Half-Life;Hematology;high risk;Human;human model;Image;imaging study;Imaging technology;Immunotherapy;Incidence;Kidney;Label;Lesion;Licensing;Localized Disease;Malignant Neoplasms;Marrow;Measurable;Measurement;Measures;Metastatic Osteosarcoma;Modality;Modeling;Monitor;mouse model;Mutation;Neoplasm Metastasis;Neuroblastoma;Normal tissue morphology;novel;novel therapeutics;Organ;Osteosarcoma;particle;Pathway interactions;patient population;Patients;Pediatric Oncology Group;Persons;pet animal;Phase;Positron-Emission Tomography;Prognosis;Radiation therapy;Radiopharmaceuticals;radioresistant;receptor;Recurrence;Red Marrow;Regimen;resistance mechanism;Safety;Scheme;Serum;Signal Pathway;Signal Transduction;single photon emission computed tomography;soft tissue;standard of care;Survival Rate;Techniques;therapy resistant;Toxic effect;translation to humans;Treatment Efficacy;Treatment Failure;treatment planning;tumor;Tumor Burden

PROJECT_TITLE: Alpha-Emitter Therapy of Osteosarcoma

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]