NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Brain Disorders;Dementia;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Prevention

PI_NAMEs: DODGE, HIROKO HAYAMA (contact)

PROJECT_TERMS: Aged, 80 and over;aging brain;Alzheimer's Disease;Alzheimer's Disease Core Center;Area;authority;Award;Biological Markers;Biomedical Engineering;Biometry;Clinical;Collaborations;collaborative environment;Communities;Computer software;Consensus;Consultations;Data;Data Coordinating Center;Data Files;data integrity;data management;data sharing;Database Management Systems;Databases;Dementia;dementia risk;design;Detection;Diagnosis;digital technology;Early Diagnosis;Education;effective therapy;Electronics;Ensure;environmental enrichment for laboratory animals;Fostering;Generations;Goals;Grant;Health Insurance Portability and Accountability Act;Home;Information Distribution;innovation;Institutional Review Boards;International;Internet;Intranet;Investigation;Knowledge;Leadership;Mediating;Medical Informatics;meetings;mild cognitive impairment;neuroimaging;neuropathology;Newsletter;novel;Oregon;outreach;Play;prevent;Procedures;programs;recruit;repository;Research;Research Personnel;Research Project Grants;response;Role;Sampling;Science;Secure;sensor;Source;Specific qualifier value;Statistical Data Interpretation;Statistical Models;Structure;success;Time;Training

PROJECT_TITLE: Data Management and Statistical Core


ADMINISTERING_IC: AA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Patient Safety;Precision Medicine;Prevention;Substance Misuse;Telehealth

ORG_CITY: ANN ARBOR

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PSYCHIATRY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative High-risk alcohol use is one of the most common risk factors for surgical complications among elective surgical patients. There is a pressing need to identify scalable intervention strategies that promote short- and longer- term alcohol use reductions in surgical settings. This sequential, multiple assignment, randomized trial will address this need by identifying the most efficacious adaptive intervention approaches to reduce alcohol use before and after surgery.

PI_NAMEs: FERNANDEZ, ANNE CHRISTIE (contact)

PROGRAM_OFFICER_NAME: WHITAKER, DAMIYA EVE

PROJECT_TERMS: Abstinence;adaptive intervention;addiction;Address;Adult;age stratification;Alcohol abuse;alcohol abuse therapy;Alcohol consumption;alcohol intervention;alcohol monitoring;alcohol risk;Alcoholism;Alcohols;Alternative Therapies;American;Area;Behavior;care episode;Caring;Dose;drinking;Early treatment;efficacy evaluation;efficacy testing;Electronic Health Record;Event;Feedback;follow-up;Health;health care settings;Health Priorities;Health Services;Health system;Healthcare;Heterogeneity;high risk;Improve Access;Individual;individual response;individualized medicine;innovation;Intervention;intervention effect;Interview;Length of Stay;Life;lifestyle factors;Link;Mainstreaming;Measures;mHealth;mhealth interventions;Monitor;Morbidity - disease rate;mortality;Motivation;National Institute on Alcohol Abuse and Alcoholism;Operative Surgical Procedures;Outcome;Participant;Patient Recruitments;Patients;Perioperative;personalized approach;Postoperative Complications;Postoperative Period;Precision Health;prevent;primary outcome;Randomized;Randomized, Controlled Trials;recruit;reduced alcohol use;remote delivery;remote intervention;Reporting;Research;responders and non-responders;Risk;Risk Factors;Role;screening;secondary outcome;Sequential Multiple Assignment Randomized Trial;sex;social stigma;surgery outcome;Surgical complication;surgical risk;telehealth;Testing;Time;tool;treatment as usual;Treatment Efficacy;treatment response;virtual coach;virtual health;Work

PROJECT_TITLE: Reducing Alcohol use among Elective Surgical Patients using Adaptive Interventions

STUDY_SECTION: AA

STUDY_SECTION_NAME: Clinical, Treatment and Health Services Research Study Section[AA-3]


ADMINISTERING_IC: AG

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PI_NAMEs: WOLTJER, RANDALL L (contact)

PROJECT_TERMS: Achievement;Age;age related changes;age related neurodegeneration;Aged, 80 and over;aging brain;Alzheimer's Disease;Antibodies;Archives;Area;Autopsy;Basic Science;Behavior monitoring;Biological;Biological Assay;Biological Markers;Brain;Brain Pathology;brain tissue;Caring;Classification;Clinical;Code;Cognitive;Collaborations;collaborative environment;Collection;Communication;Complement;Data;data management;Dementia;Development;Diagnostic;diagnostic criteria;Disease;Education;Educational process of instructing;Elderly;Electronic Mail;Elements;Evaluation;Extramural Activities;faculty mentor;Family;Family member;Freezing;guidebooks;healthy aging;Home;Human Resources;Image;Impairment;improved;Individual;Infrastructure;innovation;insight;interest;Knowledge;late life;Learning;Measures;Mentorship;Methods;mild cognitive impairment;Morphology;neuroimaging;Neurology;neuropathology;novel;novel strategies;Oregon;outreach;Participant;Pathologic;Pathology;Patients;Peripheral;Physicians;Play;Population;pre-clinical;Preparation;Productivity;Psychiatry;Psychology;Reagent;Recommendation;recruit;Reporting;repository;Research;Research Personnel;Resources;Role;Science;Scientist;Services;Specimen;Standardization;Supervision;Telephone;Testing;Time;Tissue Banks;tissue fixing;Tissues;Training;Training and Education;Work

PROJECT_TITLE: Neuropathology Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Prevention;Rural Health

PI_NAMEs: LINDAUER, ALLISON  (contact)

PROJECT_TERMS: Acceleration;Address;African American;Alzheimer's Disease;Alzheimer's disease related dementia;Asian;Awareness;Biological Markers;brain health;care outcomes;Caring;Clinical;Clinical Research;clinical trial recruitment;Clinical Trials;Collaborations;Communities;community engagement;Community Healthcare;Computers;Dementia;digital technology;Education;education research;Ensure;Equity;Event;evidence base;experience;Family;Family Caregiver;family support;Fostering;Geography;graduate student;Health;improved;Internet;Lead;Learning;Life;Minority;Minority Groups;minority undergraduate;Mission;neuroimaging;neuropathology;next generation;Oregon;outreach;Participant;participant retention;Patients;Philosophy;Postdoctoral Fellow;Prevention;programs;recruit;recruitment science;Registries;Research;Research Personnel;Research Support;Rural;Rural Community;Science;Scientist;Seasons;success;Technology;Time;Training;undergraduate student;Underrepresented Populations;Vision;Walking;Work

PROJECT_TITLE: Outreach, Recruitment and Engagement Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

PI_NAMEs: QUINN, JOSEPH F (contact)

PROJECT_TERMS: Address;Age-associated memory impairment;Aged, 80 and over;aging brain;Algorithms;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease related dementia;Alzheimer’s disease biomarker;Amyloid beta-Protein;Apolipoprotein E;Area;Award;Behavior monitoring;Biological Markers;biomarker development;Blood;Blood specimen;Clinical;cohort;Collaborations;cooperative study;Data;data sharing;Dementia;Development;Disease;Disease Progression;DNA;Education;experience;extracellular;Fostering;Funding;Genetic;Genetic Risk;Genotype;Goals;Grant;Growth;Home;Image;improved;innovation;Knowledge;late life;Measurement;Measures;microRNA biomarkers;mild cognitive impairment;Mission;Monitor;Names;Neurodegenerative Disorders;neuroimaging;neuropathology;new technology;novel;Omega-3 Fatty Acids;Oregon;Peptides;Peripheral;Plasma;Practice Guidelines;pre-clinical;Productivity;prospective;Protocols documentation;Publishing;Reagent;repository;Research;Research Peer Review;Research Personnel;Research Support;RNA;sample collection;Sampling;Single Nucleotide Polymorphism;Site;Specimen;Standardization;Structure;tau Proteins;tau-1;Technology;Testing;United States National Institutes of Health;vascular factor;Work

PROJECT_TITLE: Biomarker Core


ADMINISTERING_IC: DK

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Nutrition;Obesity;Physical Activity;Physical Rehabilitation;Prevention;Rehabilitation;Sarcopenia

ORG_CITY: BIRMINGHAM

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE Aging is associated with a progressive accrual of body fat and loss of skeletal muscle mass that causes a vicious cycle of increasing metabolic disease risk and loss of functional capacity. Intentional weight loss improves metabolic health but loss of skeletal muscle during weight loss may cause the development of sarcopenia. The proposed K01 research will use an pilot Sequential Multiple Assignment Randomized Trial to begin investigating the separate and combined effects of a higher protein diet and resistance training on the retention of fat free mass during weight loss in adults ≥50 years.

PI_NAMEs: SAYER, RICHARD DREW (contact)

PROGRAM_OFFICER_NAME: OSGANIAN, VOULA

PROJECT_TERMS: Activities of Daily Living;Address;Adherence;Adult;Aerobic;aged;Aging;Alabama;Automobile Driving;Award;Balance training;Behavior;Behavior Therapy;biological sex;Body Composition;Body fat;Body Weight decreased;career;career development;Classification;Clinical;Clinical Trials;community setting;Consumption;Counseling;Data;design;Development;Diet;Dietary Intervention;Dietary Proteins;dietary restriction;disorder risk;Education;Effectiveness of Interventions;effectiveness research;Energy consumption;Enrollment;Ensure;Equilibrium;Exercise;exercise intervention;exercise prescription;exercise training;Fatty acid glycerol esters;feasibility trial;flexibility;functional loss;Funding;Goals;Grant;Health;improved;individual response;Intervention;intervention effect;Intervention Trial;Knowledge;Maintenance;men;Mentored Research Scientist Development Award;Mentors;Metabolic;Metabolic Diseases;Monitor;muscle form;nutrition;Obesity;Outcomes Research;Participant;Phase;Pilot Projects;preference;preservation;prevent;programs;Proteins;Race;Randomized;recruit;rehabilitation research;Research;Research Project Grants;Resistance;resistance exercise;Resources;response;Role;sarcopenia;sarcopenic obesity;Scientist;secondary analysis;Sequential Multiple Assignment Randomized Trial;Sex Differences;skeletal muscle wasting;skills;Supervision;Supplementation;Testing;Training;treatment strategy;trial design;United States National Institutes of Health;Universities;Weight;weight loss intervention;weight loss program;Whey Protein;Woman;Work;Yoga

PROJECT_TITLE: Effects of a higher protein diet and resistance training on fat free mass retention during weight loss in adults over 50: A Pilot Sequential Multiple Assignment Randomized Trial

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Cerebrovascular;Dementia;Neurodegenerative;Neurosciences;Prevention;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

PI_NAMEs: SILBERT, LISA C (contact)

PROJECT_TERMS: Acceleration;Address;age related changes;age related cognitive change;Age Years;Aged, 80 and over;Aging;aging brain;Alzheimer's Disease;Alzheimer's disease related dementia;Amyloid;Autopsy;Brain;brain tissue;Cerebrospinal Fluid;Cerebrovascular Disorders;Clinical;Cognition;Cognitive;cognitive function;Collaborations;Communities;Data;Dementia;dementia risk;Development;digital imaging;Early Diagnosis;Early identification;Elderly;Fostering;Funding;Future;Genetic;Goals;healthy aging;Histopathology;Human;Image;imaging biomarker;Impaired cognition;in vivo;innovation;interest;longitudinal database;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Methods;mild cognitive impairment;Motor;neuroimaging;neuroimaging marker;novel;Oregon;Outcome;Participant;Pathologic;Positron-Emission Tomography;Prevention trial;Process;Protocols documentation;Psychometrics;Recording of previous events;Research;Research Personnel;Resources;Role;Sampling;Sequence Analysis;tau Proteins;Techniques;Technology;treatment trial;vascular cognitive impairment and dementia;Vascular Diseases;white matter

PROJECT_TITLE: Neuroimaging Core


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: NEW YORK

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: PROJECT NARRATIVE This proposal aims to develop a new approach to block MRSA progression by leveraging the anti- inflammatory activity of LXR alpha by attenuating receptor phosphorylation at serine 196 both genetically and pharmacologically using mouse models and human cells.

PI_NAMEs: GARABEDIAN, MICHAEL J. (contact);SHOPSIN, BO

PROGRAM_OFFICER_NAME: XU, ZUOYU

PROJECT_TERMS: Affect;Animals;Anti-Inflammatory Agents;Antibiotic Resistance;Antibiotic Therapy;antimicrobial;Autophagocytosis;Binding;Biogenesis;Blood;Breeding;Cardiometabolic Disease;Cell model;Cell Physiology;cell type;Cells;Cessation of life;chromatin immunoprecipitation;combat;Community-Acquired Infections;comparison control;Cultured Cells;Dose;Endothelial Cells;Enterobacteria phage P1 Cre recombinase;exosome;experimental study;Foundations;gamma secretase;Gene Expression;Genes;Hospitals;Human;Impairment;in vivo;Individual;Infection;Inflammatory;Inflammatory Response;inhibitor;Intervention;intraperitoneal;Intravenous;Knock-in Mouse;Ligands;LXRalpha protein;Macrophage;Measures;Mediating;methicillin resistant Staphylococcus aureus;monocyte;mortality;mouse model;Mus;Myeloid Cells;Natural Immunity;neutrophil;novel strategies;Pathogenesis;Pathology;Pathway interactions;Peripheral Blood Mononuclear Cell;pharmacologic;Phosphorylation;Predisposition;Preventive;programs;promoter;Publishing;receptor;Reporting;Resistance;response;Role;Serine;Serum;small molecule;Staphylococcus aureus;Staphylococcus aureus infection;Streptococcus pneumoniae;Surface;Systemic infection;targeted treatment;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;Tissues;Toxic effect;Toxin;transcription factor;transcriptome;transcriptome sequencing;United States National Institutes of Health;upstream kinase;Variant;Virulence Factors;Wild Type Mouse

PROJECT_TITLE: “Protection from MRSA lethality by inhibiting LXRα phosphorylation”

STUDY_SECTION: HIBP

STUDY_SECTION_NAME: Host Interactions with Bacterial Pathogens Study Section[HIBP]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Colorectal Cancer;Digestive Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_DEPT: PATHOLOGY

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: PROJECT NARRATIVE A stem-mesenchymal phenotype of the tumor epithelium, and its associated immunosuppressive and desmoplastic stroma, are fundamental characteristics of the most aggressive and poor survival type of colorectal cancer. Here we will test the hypothesis that the PKC/ deficiency in the intestinal epithelium underlies the upregulation of epithelial CD44 whose activation by its stromal ligands contributes to the development of this type of CRC. The successful completion of this proposal will have a high impact because a better comprehension of the signaling mechanisms that govern the mesenchymal characteristics of intestinal cancer cells is critical for the design of new and more selective therapeutic strategies.

PI_NAMEs: MOSCAT, JORGE  (contact)

PROGRAM_OFFICER_NAME: YASSIN, RIHAB R

PROJECT_TERMS: Address;Adenocarcinoma;adenoma;adverse outcome;Appearance;ATAC-seq;Automobile Driving;cancer cell;CD44 gene;Cells;Characteristics;Clinic;Collagen;colon cancer patients;Colorectal Cancer;Comprehension;Data;design;Desmoplastic;Development;Down-Regulation;Epithelial Cells;Epithelium;Growth;Human;Hyaluronan;Hyaluronidase;Immunologic Surveillance;immunosuppressed;Immunosuppression;Impairment;in vivo;Incidence;inhibitor;innovation;Intestinal Cancer;intestinal epithelium;Intestines;Knockout Mice;Laboratories;LGR5 gene;Ligands;Link;MAP Kinase Modules;MAPK8 gene;Mediating;Mesenchymal;Mitogen-Activated Protein Kinases;Molecular;Mus;Mutation;Neoplasms;neoplastic cell;new therapeutic target;novel;Organoids;osteopontin;Pathway interactions;Patients;Phenotype;Play;prevent;Process;Prognosis;Property;Publishing;receptor;Receptor Cell;Repression;Role;Sampling;Series;Signal Pathway;Signal Transduction;stem;stem cell biomarkers;stem cells;stemness;Testing;Therapeutic;Tissues;transcription factor;Transcription Factor AP-1;transcriptome sequencing;tumor;Tumor Cell Invasion;tumor initiation;Tumor Suppressor Proteins;Up-Regulation

PROJECT_TITLE: Molecular mechanisms driving mesenchymal colorectal cancer

STUDY_SECTION: MONC

STUDY_SECTION_NAME: Molecular Oncogenesis Study Section[MONC]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Bioengineering;Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Prevention

PI_NAMEs: BEATTIE, ZACHARY  (contact)

PROJECT_TERMS: advanced dementia;Aging;aging brain;Agitation;Alzheimer's Disease;Alzheimer's disease related dementia;Appointment;Area;Atrophic;Automobile Driving;Behavior;Biological Markers;care recipients;Caregivers;Clinical;Clinical assessments;Clinical Markers;Cognition;cognitive change;cohort;Collaborations;Communities;computational platform;Computers;Computing Methodologies;Data;Dementia;dementia care;Devices;Diagnosis;Digital biomarker;digital technology;Early Diagnosis;Elderly;Electronics;Environment;Evolution;experience;follow-up;Fostering;Gait speed;Genetic;Home;Impaired cognition;improved;insight;Institution;interest;Intervention;Investigation;Laboratories;Life;Liquid substance;Maps;Measurement;Measures;medial temporal lobe;Methodology;Modeling;Monitor;Moods;Motor;novel strategies;Oregon;Outcome;Pain;Participant;Pathologic;Pathology;Patient Isolation;Pattern;Peer Review;Pharmaceutical Preparations;Phase;Physical activity;Physiology;Process;programs;Protocols documentation;Psychometrics;Research;Research Personnel;Resources;Risk;Sampling;sensor;Sister;Sleep;social engagement;statistics;Symptoms;Technology;Testing;Time;training opportunity;video chat;Visit;volunteer;wearable device;white matter change

PROJECT_TITLE: Digital Technology Core


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Genetics;Intellectual and Developmental Disabilities (IDD);Neurosciences;Pediatric;Rare Diseases

ORG_CITY: CHAPEL HILL

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE The neurodevelopmental disorder Dup15q syndrome is caused by duplication of a chromosomal region containing the UBE3A gene, whose overexpression in the brain appears to be a major driver of disease pathology. Accordingly, reversing the overexpression of UBE3A represents a rational therapeutic strategy to treat Dup15q syndrome. We will optimize an approach to reduce brain UBE3A levels dose-dependently as a potential treatment.

PI_NAMEs: PHILPOT, BENJAMIN D (contact)

PROGRAM_OFFICER_NAME: TYLER, WILLIAM A

PROJECT_TERMS: Accounting;Adolescent;Adult;Age;Antisense Oligonucleotides;autism spectrum disorder;Behavioral;Biological Sciences;Brain;candidate identification;Cells;Chromosome 15;chromosome 15q duplication syndrome;Chromosome abnormality;Chromosomes;Clinical Trials;Coupled;critical period;Data;design;Disease;Dose;Electrophysiology (science);Engineering;Epilepsy;Frequencies;Functional disorder;Future;Gene Dosage;Gene Expression;Genes;Genetic;genomic locus;Human;In Vitro;in vivo;interstitial;Intervention;Isodicentric Chromosome;knock-down;Lead;Maps;Modeling;mortality;mouse model;Mus;Neonatal;Neurodevelopmental Disorder;Outcome;overexpression;Pathology;pharmacologic;Phenotype;Physiological;Population;postnatal;preclinical study;primary endpoint;prospective;Proteins;Seizures;Severities;sudden unexpected death in epilepsy;Syndrome;Testing;Therapeutic;Therapeutic Intervention;tool;Transgenes;Transgenic Organisms;UBE3A gene;Work

PROJECT_TITLE: Investigating UBE3A as a driver gene in Duplication 15q syndrome

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


NIH_SPENDING_CATS: Infectious Diseases;Urologic Diseases

ORG_CITY: Aurora

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: This proposal aims to understand the structure-function relationship of a non-canonical importer, YbtPQ, from the uropathogenic Escherichia coli, which is relevant to public health. The results will have potential for future pharmaceutical development to treat related bacterial infections, which makes the proposal align well with NIH’s mission.

PI_NAMEs: ZHENG, HONGJIN  (contact)

PROGRAM_OFFICER_NAME: ERNST, NANCY L

PROJECT_TERMS: Accounting;Address;Adopted;Anti-Bacterial Agents;Antibiotic Resistance;ATP-Binding Cassette Transporters;Back;Bacteria;Bacterial Infections;Binding;Biochemistry;Biology;Biophysics;Cell membrane;chelation;Clinical;Cryoelectron Microscopy;Data;design;Development;Drug Delivery Systems;drug development;fascinate;fighting;Future;Goals;Growth;Health;high throughput screening;Human;Infection;inhibitor;innovation;interdisciplinary approach;interest;Ions;Knowledge;Maps;Mediating;Membrane;Membrane Transport Proteins;Metals;Microbiology;Micronutrients;Mission;Modeling;Molecular;Molecular Conformation;Movement;novel;Nutritional;Nutritional Immunity;particle;pathogen;Pathogenicity;Pathway interactions;Pharmaceutical Preparations;Pharmacologic Substance;Physiological;Process;Protein Conformation;Proteins;Public Health;Resolution;Scheme;Side;Siderophores;small molecule;small molecule inhibitor;societal costs;Solvents;structural biology;Structure;Structure-Activity Relationship;Theft;Therapeutic;Time;translational impact;Transmembrane Domain;United States;United States National Institutes of Health;uptake;Urinary tract infection;Uropathogenic E. coli;Virulence;War;Woman;yersiniabactin

PROJECT_TITLE: Structural and functional studies of YbtPQ for fighting bacterial infections

STUDY_SECTION: MSFA

STUDY_SECTION_NAME: Macromolecular Structure and Function A Study Section[MSFA]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

PI_NAMEs: OKEN, BARRY S (contact)

PROJECT_TERMS: Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Budgets;career;Climate;Clinical;clinical translation;Collaborations;community organizations;Cultural Sensitivity;data sharing;Dementia;design;Development;Discipline;early experience;Education;education research;Ensure;Environment;Equilibrium;Ethics;expectation;experience;Faculty;Fire - disasters;Fostering;Future;Gifts;Goals;Grant;Habits;Human;Hunger;Individual;Infrastructure;Knowledge;Laboratories;Leadership;Learning;lectures;Life;Manuscripts;Mentors;Mind;Neurobiology;Oregon;Outcome;Personnel Management;Postdoctoral Fellow;preservation;Process;Productivity;programs;Recommendation;Recording of previous events;recruit;Research;Research Design;Research Institute;Research Methodology;Research Personnel;Resources;Scholars Program;Science;Scientist;Secure;skills;Structure;Talents;Training;Training and Education;training opportunity;Training Programs;Translational Research;United States National Institutes of Health;Work;Writing

PROJECT_TITLE: Research Education Component


ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Project Narrative Generalized seizures are brain-wide events and occur in several types of epilepsy. Asking a patient to hyperventilate is a reliable strategy to diagnose generalized absence seizures – rapid breathing triggers a seizure in nearly 100% of patients. Identifying the biological processes that intimately link respiration and generalized seizures will lead to a better understanding of how the brain triggers seizures and will pave the way forward in developing better treatments.

PI_NAMEs: BEENHAKKER, MARK  (contact)

PROGRAM_OFFICER_NAME: WHITTEMORE, VICKY R

PROJECT_TITLE: Respiration and Generalized Epilepsies

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


NIH_SPENDING_CATS: Cancer;Childhood Leukemia;Clinical Research;Health Services;Hematology;Pediatric;Pediatric Cancer;Rare Diseases;Social Determinants of Health

ORG_DEPT: PEDIATRICS

PHR: PROJECT NARRATIVE / PUBLIC HEALTH RELEVANCE While inadequate systemic exposure to oral 6-mercaptopruine (6MP) during maintenance therapy (~2y) for acute lymphoblastic leukemia (ALL) is associated with an increased risk of relapse, the underlying determinants of systemic exposure to 6MP in adolescents and young adults (AYA) have not been examined. Within a 14-site national consortium focused on AYA ALL, this proposal will examine factors which may influence systemic exposure to 6MP in AYA ALL, including those related to both the AYA patient (6MP adherence) and healthcare, as well as the barriers and facilitators within these domains. By identifying actionable targets in both domains, this proposal sets the stage to develop meaningful interventions which can mitigate outcome disparities in AYA ALL, where outcomes have lagged behind those in children.

PI_NAMEs: WOLFSON, JULIE ANNA (contact)

PROGRAM_OFFICER_NAME: CASTRO, KATHLEEN M

PROJECT_TERMS: 6-Mercaptopurine;Acute Lymphocytic Leukemia;Address;Adherence;Adolescent and Young Adult;Adult;Adult Acute Lymphocytic Leukemia;Age;age related;Behavioral Sciences;Biometry;Caring;chemotherapy;Child;Childhood;cohort;Diagnosis;Diagnostic;Disease Management;Disease remission;Disparity;DNA;Dose;drug metabolism;Enrollment;Exposure to;Geography;health belief;health care delivery;Health Personnel;Health Services Research;Healthcare;improved;Individual;Inferior;Infrastructure;innovation;Institution;Intervention;Interview;Investigation;Knowledge;leukemia treatment;Leukocytes;Maintenance;Maintenance Therapy;Malignant Neoplasms;Measures;medication compliance;Methods;Modeling;Monitor;novel;Nucleotides;Oncology;oncology service;Oral;Outcome;outcome disparities;Outcomes and Health Services Research;Patient Care;Patient Self-Report;Patients;peripheral blood;Pharmacogenetics;Pharmacology;Phase;Population;Process;Prospective cohort;Provider;Psychosocial Factor;public health relevance;Qualitative Research;Questionnaires;Recurrent disease;Regimen;Relapse;relapse risk;Research Design;Role;Services;Site;Social support;sociodemographics;Structure;Survival Rate;System;Thioguanine;Time;young adult

PROJECT_TITLE: Predictors of Systemic Exposure to Oral 6MP During Maintenance in Adolescentsand Young Adults with Acute Lymphoblastic Leukemia

STUDY_SECTION: NRCS

STUDY_SECTION_NAME: Nursing and Related Clinical Sciences Study Section[NRCS]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Genetics

ORG_CITY: WORCESTER

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

ORG_STATE: MA

PHR: Public Health Relevancy Statement/Project Narrative tRNAs are the link required to translate genomic information from RNA copies of the genome into the amino acid sequences that make up proteins. Interestingly, tRNAs are among the most heavily-modified RNAs in the cell, and tRNA-modifying enzymes have been linked to an ever-increasing range of disease processes. In addition, tRNAs often cleaved in response to changes in environmental conditions, and the resulting fragments are increasingly understood to play underappreciated roles in the cell. In this proposal we will systematically investigate the biology of tRNA modification in control of tRNA cleavage and control of protein translation.

PI_NAMEs: RANDO, OLIVER J (contact)

PROGRAM_OFFICER_NAME: KENT, TRAVIS JOHN

PROJECT_TERMS: Address;Affect;Alleles;Amino Acid Sequence;Amino Acids;angiogenin;Anticodon;Biochemical;Biogenesis;Biological Assay;Biology;cell growth;Cells;Codon Nucleotides;Collection;conditional mutant;Cytosine;deep sequencing;Diabetes Mellitus;Disease;Disparate;DNA Modification Methylases;embryonic stem cell;Enzymes;ES Cell Line;Event;experimental study;Genetic;Genetic Code;Genome;Genomics;Growth;Homeostasis;human disease;In Vitro;in vivo;Infertility;insight;Link;Malignant Neoplasms;Mammals;Mediating;Metabolic;Methylation;model organism;Modeling;Modification;Mus;mutant;Nerve Degeneration;nuclease;Nucleotides;Organism;overexpression;Play;Predisposition;Process;Production;Proteins;Public Health;reconstitution;Regulation;Resources;response;Ribosomes;RNA;Role;Saccharomycetales;Small RNA;Stress;Surveys;System;Transfer RNA;Transfer RNA Aminoacylation;Translating;Translational Regulation;Translations;Yeasts

PROJECT_TITLE: Regulation of tRNA fragment biogenesis and function by nucleotide modifications

STUDY_SECTION: GCAT

STUDY_SECTION_NAME: Genomics, Computational Biology and Technology Study Section[GCAT]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cancer;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurodegenerative;Neurosciences;Prevention;Rehabilitation;Social Determinants of Health

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

PHR: PROJECT NARRATIVE There is a critical need to understand the long-term aging process of the growing population of older cancer survivors. The goal of this proposal is to identify long-term memory trajectories of older cancer survivors in the US and England, evaluate socioeconomic disparities in this relationship, and identify modifiable Alzheimer’s disease and related dementia (ADRD) risk factors. This study’s findings will enhance our understanding of the long-term aging process of older cancer survivors and identify potential intervention targets to promote healthy aging in this growing population.

PI_NAMEs: WESTRICK, ASHLY C (contact)

PROGRAM_OFFICER_NAME: TORRES, DELANY

PROJECT_TERMS: Acceleration;Accounting;Acute;Address;Age;Aging;aging process;Alzheimer's disease related dementia;cancer diagnosis;cancer epidemiology;Cancer Patient;Cancer Survivor;Cancer Survivorship;cardiovascular health;career;Clinic;Cognitive;cohort;comorbidity;Complex;Comprehensive Health Care;Country;Data;Data Analyses;dementia risk;Diabetes Mellitus;Diagnosis;Diagnostic;Economics;Education;England;Environment;Equity;experience;General Population;Goals;Government;Health;Health and Retirement Study;health care availability;health difference;Healthcare Systems;healthy aging;high risk population;human old age (65+);Hypertension;Income;Individual;individual variation;Inequality;Intervention;Interview;Knowledge;late life;Leadership;long term memory;Longitudinal Studies;Malignant Neoplasms;Measurement;Memory;Memory Loss;Mental Depression;Mental Health;Mentorship;modifiable risk;multilevel analysis;neighborhood disadvantage;Neighborhoods;Obesity;older adult;Older Population;older women;Persons;Phase;Physical activity;Policies;Politics;Population;population based;Positioning Attribute;prevent;Proxy;recruit;Research;Research Personnel;resilience;resilience factor;Risk;Risk Factors;Role;safety net;Sampling;sex;Short-Term Memory;social;social determinants;social epidemiology;Social support;social vulnerability;socioeconomic disparity;Socioeconomic Factors;socioeconomics;Survivors;survivorship;Symptoms;Training;United Kingdom;United States;Variant

PROJECT_TITLE: Risk and Resilience Factors in Memory Aging Among Older Cancer Survivors: A Cross Country Comparison of the US and England

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development Facilitating The Transition to Independence Study Section[AGCD-1]


ADMINISTERING_IC: DC

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Behavioral and Social Science

ORG_CITY: CLEVELAND

ORG_DEPT: PSYCHOLOGY

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative This proposal describes an innovative, collaborative, inter-institutional mentoring program between Case Western Reserve University and Hampton University to support underrepresented minority (URM) students in communication sciences and disorders (CSD). The purpose of this program is to enhance the diversity of the CSD workforce to better serve all people with communication disorders by successfully transitioning URM students to CSD graduate programs and by developing strong networks of mentors to foster long-term success. Over the course of the annual programming, students will advance their professional development skills, build a diverse professional network, increase their sense of belonging in the field, particularly research, increase their knowledge of CSD professions, and enhance their self-efficacy, resulting in increased URM student achievement and retention in CSD.

PI_NAMEs: CALANDRUCCIO, LAUREN  (contact)

PROGRAM_OFFICER_NAME: RIVERA-RENTAS, ALBERTO L

PROJECT_TERMS: Achievement;Affinity;Black race;boys;career;career networking;Clinical;cohort;Collaborations;Communication;Communication impairment;design;Development;Dimensions;Disease;empowerment;Environment;Equity;experience;Female;Fostering;Foundations;Goals;Graduate Degree;graduate student;Grant;hearing impairment;Historically Black Colleges and Universities;Hospitals;Hour;improved;improved outcome;Individual;innovation;Institution;inter-institutional;interest;Intervention;Knowledge;Learning;Manuals;meetings;Mentors;Mentorship;Minority Groups;Minority-Serving Institution;Mission;Modeling;Motivation;National Institute on Deafness and Other Communication Disorders;Neighborhoods;Not Hispanic or Latino;Oral;Outcome;Patient Care;peer;peer coaching;peer support;people of color;Persons;Population;Professional Organizations;programs;recruit;Research;Resource Development;Science;Self Efficacy;service learning;skill acquisition;skills;Speech-Language Pathology;Structure;student participation;Student recruitment;student retention;Students;success;Technical Expertise;Training;Training Programs;Travel;treatment strategy;undergraduate student;Underrepresented Minority;underrepresented minority student;Universities;Work;Writing

PROJECT_TITLE: IMPACT: Promoting Diversity and the Success of Underrepresented Minority Students in the Clinical and Research Workforce for Communication Sciences and Disorders


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Autoimmune Disease;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Multiple Sclerosis;Neurodegenerative;Neurosciences

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: NARRATIVE The proposed research aims to unify and improve simultaneous diffusion-based magnetic resonance imaging of the brain and spinal cord in order to study the complete motor pathways in vivo and to study their involvement in patients with multiple sclerosis. Previously, the brain and spinal cord have been studied in isolation due to challenges associated with long image acquisitions, different demands on resolution and acquisition paradigms, tissue modeling, and connectivity analysis. The proposed studies will provide a basis for understanding the role of the motor pathways in normal and damaged white matter microstructure in multiple sclerosis, and provide a foundation for further applications in diseases that involve both brain and spinal cord tissues.

PI_NAMEs: SCHILLING, KURT G (contact)

PROGRAM_OFFICER_NAME: GATLIN, TINA L

PROJECT_TERMS: Address;Affect;Anatomy;Axon;axon injury;Biological Markers;Biophysical Process;Brain;Brain imaging;Brain Mapping;brain pathway;Brain Stem;burden of illness;Central Nervous System;Central Nervous System Diseases;Clinical;Clinical assessments;cohort;Complex;Corticospinal Tracts;Demyelinations;Deterioration;Development;Diffusion;Diffusion Magnetic Resonance Imaging;disability;Disease;Disease Progression;Edema;Evaluation;Evolution;Fiber;Foundations;Goals;Health;Human;Image;Image Analysis;image processing;Impairment;improved;in vivo;indexing;Investigation;Lesion;Literature;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Maps;Measures;Medical Imaging;Methods;Modeling;Morphologic artifacts;motor impairment;Motor Pathways;Multiple Sclerosis;Multiple Sclerosis Lesions;multiple sclerosis patient;Nervous System Disorder;Neurologic;Pathologic;Pathology;Pathway interactions;Prognosis;Radiology Specialty;Reproducibility;Research;Resolution;Role;Sensitivity and Specificity;Specificity;Spinal Cord;Spinal cord damage;Spinal Cord Diseases;spinal pathway;stem;Structural Models;Structure;Swelling;Techniques;Technology;Time;Tissue Model;Tissues;tractography;Water;white matter;white matter damage

PROJECT_TITLE: Microstructure and connectivity modeling from the cortex to the spinal cord in Multiple Sclerosis


NIH_SPENDING_CATS: Neurodegenerative;Neurosciences

ORG_CITY: COLUMBIA

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

ORG_STATE: SC

PHR: PROJECT NARRATIVE Higher levels of serum urate are associated with slower disease progression and improved survival in several neurodegenerative movement disorders, suggesting that urate levels may have prognostic utility in Parkinson’s Disease or Amyotrophic Lateral Sclerosis. Despite this, urate elevation therapy does not slow clinical disease progression. In this proposal we suggest an alternative fate of urate that may better explain why urate levels are low early in the disease diagnosis, and we propose to develop tools to better characterize this process.

PI_NAMEs: FRIZZELL, NORMA  (contact)

PROGRAM_OFFICER_NAME: SWANSON-FISCHER, CHRISTINE R

PROJECT_TERMS: Acceleration;Address;adduct;Albumins;Amyotrophic Lateral Sclerosis;Antibodies;Antioxidants;cell type;Cellular Stress;Chemicals;Circulation;Clinical;clinical prognosis;Collection;Corpus striatum structure;Coupled;Detection;Diagnosis;Disease;disease diagnosis;Disease Progression;dopamine transporter;Epitopes;Equilibrium;Excision;Exposure to;Future;Generations;Goals;Human;Hydrogen Peroxide;Immunoglobulin G;improved;In Vitro;Infiltration;Inflammation;Inflammatory;Inosine;Investigation;Libraries;Link;Location;Lymphocyte;Lysine;Measurement;men;Microglia;motor deficit;Movement Disorders;Natural regeneration;Nature;Nerve Degeneration;Neurodegenerative Disorders;Neurons;neutrophil;novel;oxidation;oxidative damage;Oxidative Stress;Parkinson Disease;Patient-Focused Outcomes;Patients;Peptides;Peroxidases;Peroxonitrite;Placebos;Plasma;polyclonal antibody;Population;Post-Translational Protein Processing;Pre-Clinical Model;Predisposition;prevent;Process;Prognosis;Prognostic Marker;prognostic value;protein function;protein metabolite;protein structure;Proteins;Proteomics;Research Personnel;Rheumatoid Arthritis;Role;Serum;Sodium Chloride;Spinal Cord;Superoxides;Supplementation;Testing;Time;tool;Treatment Efficacy;Urate;Uric Acid;Woman

PROJECT_TITLE: Developing Tools to Understand an Alternative Fate of Urate in Neurodegenerative Diseases

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD]


NIH_SPENDING_CATS: Biotechnology;Cancer;Immunization;Immunotherapy;Lung;Lung Cancer;Prevention;Stem Cell Research;Stem Cell Research - Embryonic - Human;Vaccine Related

ORG_CITY: LOUISVILLE

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF LOUISVILLE

ORG_STATE: KY

PHR: Project Narrative Lung cancer patients remain at elevated risk for relapse following conventional treatment and recent studies of lung cancer biology provide compelling evidence that lung cancer is initiated by a small population of malignant cells called cancer-initiating cells (CICs); currently available cancer treatments may be ineffective against lung CICs. Our preliminary work using a vaccine consisting of exosomes derived from mouse embryonic stem cells (ES-exo vaccine) has provided validation that immunization with ES-exo vaccine prevents lung cancers in mice and our goal in this proposal is to investigate whether our novel cell-free ES-exo vaccine is effective in depleting lung CICs and preventing lung cancer onset and recurrence. Such a cancer vaccine will reduce health care costs and loss of life from a disease that is now a major health problem worldwide.

PI_NAMEs: LI, CHI ;YADDANAPUDI, KAVITHA  (contact)

PROGRAM_OFFICER_NAME: VLAD, ANDA MIOARA

PROJECT_TERMS: Address;Adenocarcinoma;Adjuvant;Adult;Age Months;Allogenic;anti-cancer;anti-tumor immune response;Antigens;antitumor effect;Autoimmunity;Binding;Biology;Cancer Biology;cancer cell;Cancer Etiology;cancer initiation;Cancer Patient;cancer prevention;cancer therapy;cancer type;Cancer Vaccines;Carcinogens;Cause of Death;CD34 gene;CD8B1 gene;Cell Proliferation;cell type;Cells;Cessation of life;Chemotherapy and/or radiation;Consumption;conventional therapy;cross reactivity;cytotoxic;Data;Daughter;Development;Disease;efficacy testing;Embryo;embryonic antigen;embryonic stem cell;exosome;experimental study;Fibroblasts;Goals;Grant;Granulocyte-Macrophage Colony-Stimulating Factor;Growth;Health;Health Care Costs;Human;human embryonic stem cell;humanized mouse;Immune;Immune response;Immunity;Immunization;Immunize;Immunophenotyping;Implant;In Vitro;in vivo;Injections;insight;intercellular communication;Invaded;KRASG12D;Laboratories;Lewis Lung Carcinoma;Life;Lung Adenocarcinoma;lung cancer prevention;lung development;Lung Neoplasms;lung tumorigenesis;Malignant neoplasm of lung;Malignant Neoplasms;Mediating;Membrane;Messenger RNA;Methodology;MicroRNAs;Modality;Molecular;Mouse Embryonic Stem Cells;mouse model;Mus;Mutation;Neoplasm Metastasis;neoplastic cell;Non-Small-Cell Lung Carcinoma;novel;oncofetal antigen;patient derived xenograft model;Population;prevent;Preventive vaccine;Proliferating;Property;prophylactic;Proteins;Proteomics;Publishing;Recurrence;Recurrent disease;Relapse;relapse risk;Reporting;Resistance;response;Risk;Rodent;screening;self-renewal;Solid Neoplasm;Source;Specificity;Splenocyte;stem cell biomarkers;stem cell exosomes;stem cells;Teratoma;Testing;Tissues;Toxic effect;trait;Transgenic Organisms;translational potential;tumor;Tumor Antigens;Tumor Immunity;tumor progression;Tumor Stem Cells;Tumor-infiltrating immune cells;Vaccinated;Vaccination;vaccination strategy;vaccine development;vaccine efficacy;Vaccines;Validation;Vesicle;Work;Xenograft procedure

PROJECT_TITLE: A Stem Cell Based Exosomal Vaccine for the Prevention of Cancer


ADMINISTERING_IC: OD

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Biotechnology

ORG_CITY: DAVIS

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

ORG_STATE: CA

PHR: Project Narrative The UC Davis T35 Students Training in Advanced Research (STAR) program is a primary means of providing DVM students a balanced experience to hands-on hypothesis driven research that builds broadly applicable skills in critical thinking and problem-solving. The proposed training program is consistent with recommendations to give federal agencies more control over the number of trainees, the quality of their training, and the appropriateness of training to meet pressing societal needs. Funds are requested to provide 10-week stipend support for each of 15 DVM trainees annually who will receive a combination of didactic and experiential training to promote understanding of how students progressing through their professional clinical curriculum can incorporate rigorous research training into their career goals, and the benefits of doing so.

PI_NAMEs: BANNASCH, DANIKA L (contact)

PROGRAM_OFFICER_NAME: TANDON, RITESH

PROJECT_TERMS: Academia;Animal Feed;Animals;Biomedical Engineering;Biomedical Research;Caenorhabditis elegans;Clinical Research;Companions;Complex;Disease;Educational Curriculum;Environment;Epidemiology;experience;experimental study;Faculty;fundamental research;Genetically Modified Organisms;Genomics;Gnotobiotic;Government;Health;Human;Image;Inhalation;innovation;interest;Knowledge;Leadership;Medicine;member;Mentors;metabolomics;Mission;Modernization;Molecular;Motivation;multidisciplinary;Nature;next generation;nonhuman primate;Positioning Attribute;post-doctoral training;pre-doctoral;Private Sector;Productivity;programs;Proteomics;Request for Applications;Research;Research Project Grants;Research Proposals;responsible research conduct;Review Committee;Rodent;Science;Scientist;sound;Structure;student training;Students;success;Teacher Professional Development;Technical Expertise;Technology;Training;Training Programs;Translational Research;transmission process;undergraduate student;United States National Institutes of Health;Vector-transmitted infectious disease;Zebrafish

PROJECT_TITLE: Students Training in Advanced Research


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Brain Disorders;Cocaine;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Natural Products;Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: GALVESTON

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

ORG_STATE: TX

PHR: PROJECT NARRATIVE Cocaine is the second highest abused drug in the United States, resulting in users responding with less immunological severity to human immunodeficiency virus (HIV)-1 then non-users. Long-term cocaine exposure, especially in comorbidity with HIV-1, promotes neuroinflammation-associated toxicities as a result of unmanageable inflammatory responses and decreased antiviral immunity. This project addresses the pathogenic chronic inflammatory states, initiated by cocaine's impact and activation of MAVS and AIM2 inflammasome signaling in HIV—1; that ultimately results in decreased antiviral immunity and heightened inflammation, thereby fueling disease progression and tissue injury in HIV-associated neurocognitive disorders.

PI_NAMEs: CISNEROS, IRMA  (contact)

PROGRAM_OFFICER_NAME: TSAI, SHANG-YI ANNE

PROJECT_TERMS: Address;AIM2 gene;Anti-viral Response;Antioxidants;antiviral immunity;Astrocytes;Attenuated;Binding;CASP1 gene;Caspase;Central Nervous System Diseases;chemokine;Chronic;Cocaine;cocaine exposure;comorbidity;cytokine;Development;Disease Progression;drug of abuse;Equilibrium;Event;Failure;Flavonoids;Future;Generations;Genes;HIV;HIV-1;HIV-associated neurocognitive disorder;Immune response;Immunologics;Infection;Inflammasome;Inflammation;Inflammatory;Inflammatory Response;Innate Immune Response;Interferons;Intervention;Measures;Mediating;Mitochondria;neuroinflammation;neurotoxicity;novel;Outcome;Pathogenicity;Pathology;Pattern recognition receptor;Pharmaceutical Preparations;Phenotype;Phosphorylation;Phosphotransferases;Play;Production;protein activation;protein aggregation;protein function;Protein Inhibition;Proteins;Proteolysis;Quercetin;receptor;recruit;Recurrence;Regulation;Reporting;Response Elements;Risk;Role;scaffold;Severities;Signal Transduction;Signal Transduction Pathway;Signaling Protein;Testing;tissue injury;Toxic effect;United States;Viral;Viral Physiology

PROJECT_TITLE: AIM(2)ing at the inflammasome: Impact of MAVS signaling in cocaine-and HIV-1 induced neuroinflammation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IMM-F(50)R]


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Hepatitis;Liver Disease;Nutrition;Obesity;Prevention

ORG_CITY: NEW HAVEN

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative This application will elucidate novel regulatory organisms underlying the role of myeloid cell m6A methylation to drive hepatic inflammation during obesity-associated NAFLD. The identification of DDX21 as a key role in liver myeloid cell subsets to promote hepatic inflammation will provide the rationale for manipulating DDX21 and the basis for applying small molecules targeting m6A regulators in metabolic liver disease.

PI_NAMEs: OUYANG, XINSHOU  (contact)

PROGRAM_OFFICER_NAME: GARCIA, MARTHA

PROJECT_TERMS: Binding;Biogenesis;Biological;biological adaptation to stress;Cells;Characteristics;Collaborations;Data;Diet;diet-induced obesity;differential expression;Disease Progression;DNA Damage;efficacy testing;endoplasmic reticulum stress;Enzymes;Epigenetic Process;epigenome;Fibrosis;FRAP1 gene;Gene Expression;Gene Expression Regulation;Genes;Genetic Transcription;Grant;Hepatic;Homeostasis;immune cell infiltrate;improved;Inflammation;Inflammatory;inflammatory marker;Kupffer Cells;Liver;Liver diseases;liver inflammation;Macrophage;Maps;Messenger RNA;Metabolic;Methylation;Methyltransferase;Modification;Molecular;monocyte;mRNA Stability;mRNA Transcript Degradation;Mus;Myelogenous;Myeloid Cells;NF-kappa B;non-alcoholic fatty liver disease;novel;Nucleotides;Obesity;Organism;Pathway interactions;Phenocopy;Phenotype;Play;Population;Post-Transcriptional Regulation;prevent;Prevention;prophylactic;Protein Methyltransferases;Proteins;Reaction;Reader;recruit;Reporting;Research;Resolution;response;Ribosomes;Risk Factors;RNA;RNA Editing;RNA Helicase;RNA Transport;Role;single-cell RNA sequencing;Site;small molecule;small molecule inhibitor;Specificity;Steatohepatitis;Testing;Therapeutic;therapeutic target;Transcript;transcriptome;transcriptomics

PROJECT_TITLE: RNA m6A methylation contributes to hepatic inflammation in obesity-associated NAFLD

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-R(04)]


ED_INST_TYPE: SCHOOLS OF EDUCATION

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Drug Abuse (NIDA only);Electronic Nicotine Delivery Systems;Prevention;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: LOGAN

ORG_NAME: UTAH STATE UNIVERSITY

ORG_STATE: UT

PHR: Project Narrative This project will validate a novel pre-clinical rodent electronic nicotine delivery system (e-cigarette). We will also examine the influence of biological sex, fruit flavor, and epigenetic modification on e-cigarette use by rats. This research ultimately aims to help understand and devise prevention and treatment for nicotine addiction in people.

PI_NAMEs: ODUM, AMY  (contact)

PROGRAM_OFFICER_NAME: MOORE, HOLLY MARIE

PROJECT_TERMS: addiction;Address;Animals;Area;Award;Basic Science;Behavior;biological sex;Blood;Brain;cardiovascular health;Cause of Death;Cigarette;Complex;cost;Cotinine;Data;Data Analyses;Deposition;Development;Dose;drug misuse;drug of abuse;Drug usage;Electronic cigarette;electronic cigarette use;electronic liquid;Electronic Nicotine Delivery Systems;Enhancers;Epigenetic Process;experience;experimental analysis;Experimental Designs;Exposure to;Extinction;Face;Female;Flavoring;Fruit;Goals;Health;health disparity;Histone Deacetylase;Histone Deacetylase Inhibitor;Human;improved;Inhalation;Injections;innovation;Intake;Investigation;Maintenance;male;Malignant Neoplasms;Measures;Methods;Modeling;Modification;Nicotine;Nicotine Dependence;nicotine treatment;nicotine use;nicotine vapor;Nose;novel;novel strategies;open source;Persons;Pharmaceutical Preparations;Phase;Physiological;Physiology;Play;Policies;Population;pre-clinical;Pre-Clinical Model;pre-clinical research;prevent;preventable death;Prevention;Psychological reinforcement;public repository;Publications;Rattus;Regimen;reinforcer;Relapse;Reproducibility;Research;respiratory health;Rewards;Rodent;Rodent Model;Role;Self Administration;sex as a biological variable;Smoking;Sodium Butyrate;Sodium Chloride;therapy development;Time;Tobacco;Tobacco smoking behavior;Tobacco use;Training;uptake;Validation;vaping;vaping nicotine;vapor;Withdrawal;Woman;young adult;Youth

PROJECT_TITLE: The Rodent Electronic Nicotine Delivery System (RENDS): Behavior, physiology, and epigenetics


NIH_SPENDING_CATS: Breast Cancer;Cancer;Cancer Genomics;Genetics;Human Genome;Microbiome;Prevention;Women's Health Research

PHR: PROJECT NARRATIVE Defining early ‘triggers’ that exist within the mammary tissue of non-tumor bearing individuals and establishing how these triggers enhance long-term risk for metastatic hormone receptor positive breast cancer would have a substantial impact on reducing the mortality associated with this disease. We have identified that gut commensal dysbiosis is an early trigger that induces specific immune changes in the normal mammary tissue that lead to enhanced long-term risk for metastatic breast cancer. This project will establish how the gut microbiome distally regulates normal mammary tissues to enhance early tumor dissemination, the impact of which could lead to therapies that modify the gut microbiome, host metabolism, or tissue microenvironment for the long-term prevention of metastatic breast cancer.

PI_NAMEs: RUTKOWSKI, MELANIE R (contact)

PROGRAM_OFFICER_NAME: SNYDERWINE, ELIZABETH G

PROJECT_TERMS: acylcarnitine;Adoptive Transfer;Affect;Benign;Bile Acids;Biodiversity;Blood;Breast;Breast Cancer Patient;CCL2 gene;Cell Communication;Cell Degranulation;Cells;Clinical;clinically relevant;cost;Data;Detection;Diagnosis;Dinoprostone;Disease;Disease Outcome;Distal;Distant;Drug Combinations;dysbiosis;Environment;epidemiology study;Estrogen Receptors;experience;Fibroblasts;Gene Expression;Genomics;Goals;Growth;gut microbiome;gut microbiota;high risk;Histologic;Homeostasis;Hormone Receptor;hormone receptor-positive;Immune;Immunofluorescence Immunologic;Incidence;Individual;Inflammation;Inflammatory;Insulin Resistance;Intervention;Link;Lung;lymph nodes;Macrophage;Malignant Breast Neoplasm;mammary;Mammary Gland Parenchyma;Mammary Neoplasms;mast cell;Mediating;Medical;Metabolic;Metabolism;Metastatic breast cancer;microbial;microbiome;Modeling;Modification;Molecular;mortality;mouse model;Mus;Neoplasm Metastasis;neoplastic cell;new therapeutic target;Newly Diagnosed;Normal tissue morphology;novel;Outcome;Pathway interactions;Patients;Pharmaceutical Preparations;pharmacologic;Phenotype;Predisposition;premalignant;prevent;Prevention;Primary Neoplasm;progesterone receptor positive;recruit;Recurrence;Relapse;Reporter;response;restoration;Risk;Role;Sampling;Signal Pathway;Testing;Therapeutic;Tissues;treatment response;tumor;tumor diagnosis;tumor growth;tumor initiation;tumor microenvironment;Tumor-associated macrophages;Up-Regulation;Woman;Work

PROJECT_TITLE: Gut microbiome-mediated differences within the pre-malignant mammary tissue environment enhance early breast tumor metastasis

STUDY_SECTION: TME

STUDY_SECTION_NAME: Tumor Microenvironment Study Section[TME]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Biomedical Imaging;Cancer;Cardiovascular;Clinical Research;Heart Disease;Hematology;Orphan Drug;Patient Safety;Physical Activity;Prevention;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_CITY: RICHMOND

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

PHR: PROJECT NARRATIVE The success of hematopoietic cell transplantation to treat hematologic cancer is significantly limited in those with poor exercise tolerance, but current methods to measure exercise capacity in these patients do not identify the reasons for their exercise intolerance. To better understand and ultimately address the causes of exercise intolerance, we will directly assess the relationship between heart function (using noninvasive cardiac magnetic resonance imaging during exercise) and its contribution on exercise capacity in hematopoietic cell transplant patients before and after transplant. This K23 project will allow training of an early-stage investigator to become an independent clinical researcher in cardio-oncology and develop expertise in exercise magnetic resonance imaging to understand the reasons for exercise intolerance—ultimately leading to future study of targeted treatments to improve outcomes among those receiving hematopoietic cell transplantation.

PI_NAMEs: CANADA, JUSTIN MCNAIR (contact)

PROGRAM_OFFICER_NAME: WOO, SEUNG KYOON

PROJECT_TERMS: Acute Myelocytic Leukemia;Address;adverse event risk;Allogenic;Assessment tool;Biomedical Engineering;Body Weight decreased;Canada;Cancer Center;cancer therapy;Cardiac;cardiac magnetic resonance imaging;Cardiac Output;Cardiopulmonary;Cardiovascular Diseases;Cardiovascular system;career development;Clinical;Clinical Management;Clinical Oncology;Clinical Trials;cofactor;Collection;Communities;comorbidity;Coupled;curative treatments;Data;design;Development Plans;disability;Disease;Doctor of Philosophy;Early Diagnosis;Elderly;Eligibility Determination;Environment;Equation;Equipment;Evaluation;Exclusion;Exercise;exercise capacity;exercise intolerance;exercise physiologist;Exercise Tolerance;exhaustion;Exposure to;Feasibility Studies;frailty;functional status;Future;Gait speed;Gases;Goals;Health;Heart failure;heart function;heart imaging;Hematologic Neoplasms;Hematopoietic Stem Cell Transplantation;Imaging Techniques;Impairment;improved;improved outcome;Individual;innovation;interest;International;Intravenous;Ionizing radiation;leukemia;leukemia treatment;Life;Magnetic Resonance;Magnetic Resonance Imaging;Malignant Neoplasms;Measurement;Measures;Mentored Patient-Oriented Research Career Development Award;Mentors;Methodology;Methods;Morbidity - disease rate;mortality;mortality risk;multidisciplinary;Muscle;Myocardial dysfunction;novel;older patient;Oncologist;Oncology;Outcome;Oxygen;Oxygen Consumption;patient oriented;Patients;Peripheral;Phenotype;Physical activity;Physical Performance;Physicians;Play;Principal Investigator;Procedures;programs;Publications;Qualifying;Quality of life;Relapse;Reproducibility;Research;Research Personnel;Research Training;responsible research conduct;Risk;Role;Scientist;Serious Adverse Event;side effect;Stress;success;supportive environment;Survivors;Syndrome;targeted treatment;Techniques;temporal measurement;Testing;theories;Therapeutic Intervention;Time;Training;translational scientist;Transplant Recipients;Transplantation;transplantation therapy;Treatment-Related Cancer;Virginia

PROJECT_TITLE: The Relationship of Exercise Associated Cardiac Reserve on Peak Oxygen Consumption and Frailty Measures in Individuals Undergoing Allogeneic Hematopoietic Stem Cell Transplant.

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(OA)]


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Genetics;Hematology;Human Genome;Orphan Drug;Rare Diseases;Sickle Cell Disease

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: NARRATIVE Sickle cell disease (SCD) is one of the most common genetic disorders in the world. It is characterized by many acute manifestations most notably the acute chest syndrome (ACS), a severe lung complication that causes premature death in SCD. Currently, there is no specific treatment for ACS, and so it continues to be a major clinical problem globally. We have identified a potential reason that might explain why children survive ACS 10-times better than adults. This project will help us understand the protection in children, and to see if we can exploit it to develop a new and specific treatment for ACS for all patients.

PI_NAMEs: OFORI-ACQUAH, SOLOMON FIIFI (contact)

PROGRAM_OFFICER_NAME: QASBA, PANKAJ

PROJECT_TERMS: Acute;acute chest syndrome;Acute Lung Injury;Adult;Africa;African;Age;Azacitidine;Biological;Blood;Blood Cells;Blood Circulation;Cells;Cessation of life;Child;Clinical;cohort;Complication;conditional knockout;CpG Islands;Data;demethylation;design;DNA Methylation;DNA Sequence;Dose;efficacy testing;Enrollment;enzyme activity;Enzymes;Epigenetic Process;experience;experimental study;extracellular;functional genomics;Genes;Genetic;Genetic Diseases;genome sequencing;genome-wide;Genomics;Ghana;Health;Heme;heme oxygenase-1;Hemolysis;HL60;Human;improved;Individual;Inflammatory;Infusion procedures;Iron;knock-down;Knock-out;Liver;Longitudinal cohort;Lung;Measures;Messenger RNA;Methylation;MicroRNAs;Modeling;Molecular;mRNA Expression;Mus;next generation;next generation sequencing;novel;Organ;Outcome;overexpression;Pathogenesis;Patients;Peripheral Blood Mononuclear Cell;Pilot Projects;Plasma;Population;Pre-Clinical Model;Pregnant Women;premature;prevent;Process;Production;promoter;prophylactic;Proteins;Recombinants;Reporting;Research;Respiratory distress;Risk;Role;Sampling;Sickle Cell Anemia;Signal Transduction;Site;Stress;Survival Rate;targeted treatment;Testing;Therapeutic;therapeutic target;Time;TLR4 gene;Toxic effect;Transgenic Mice;Transgenic Organisms;Variant;whole genome

PROJECT_TITLE: Therapeutic Targets in Acute Chest Syndrome

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CVRS-A(05)]


NIH_SPENDING_CATS: Brain Disorders;Congenital Structural Anomalies;Genetics;Human Genome;Infant Mortality;Neurosciences;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: NARRATIVE Recent work from our group has demonstrated that PRDM15, a member of the PRDM family of transcription regulators, is essential in early embryogenesis leading to defects in growth, Anterior/Posterior patterning and Forebrain development. Here we propose to further investigate the function, at the mechanistic level, of PRDM15 at different stages of development and to identify its relevant downstream targets. Our work will not only expand our knowledge on basic developmental processes, but given mutations of the PRDM15 gene and of PRDM15-transcriptional targets in the NOTCH and WNT/PCP patways, detected in patients with Holoprosencephaly (HPE) and microcephaly, will also have a potential diagnostic and therapeutic impact.

PI_NAMEs: GUCCIONE, ERNESTO  (contact)

PROGRAM_OFFICER_NAME: KOSTER, MARANKE IRENE

PROJECT_TERMS: Accounting;Affect;Anterior;Automobile Driving;Biological Process;Brain;brain malformation;Cause of Death;Cells;Cephalic;Cessation of life;Chromatin;Clinical;cohort;Collaborations;Congenital Abnormality;congenital anomaly;Craniofacial Abnormalities;Critical Pathways;Data;Defect;defined contribution;Development;Developmental Process;Diagnostic;diagnostic screening;Disease;Embryo;Embryonic Development;embryonic stem cell;Embryonic Structures;Epigenetic Process;epigenomics;Erinaceidae;Event;Eye;Failure;Family;Fingers;Follow-Up Studies;Forebrain Development;Gene Expression;Genes;Genetic;Genetic Determinism;genetic testing;Genetic Transcription;genetic variant;Goals;Growth;Head;Healthcare Systems;Heterozygote;Holoprosencephaly;Human;improved;In Vitro;in vivo;Individual;Infant;Knowledge;Lifelong disability;Link;malformation;MAP Kinase Gene;Mediating;member;Microcephaly;Mining;Molecular;Molecular Diagnosis;Morbidity - disease rate;mouse genetics;Mus;Mutate;Mutation;Nature;Neonatal Mortality;Newborn Infant;NOTCH3 gene;novel;Oncogene Deregulation;Pathogenicity;Pathway interactions;Patients;Pattern;Phenotype;prevent;Primitive Streaks;progenitor;programs;Prosencephalon;Proteins;Regenerative Medicine;Reporting;Research Project Grants;Risk;Role;Science;Shapes;SHH gene;Signal Pathway;Signal Transduction;Specific qualifier value;stem;Structural defect;Structure;System;targeted sequencing;Testing;Therapeutic;transcription factor;Transcriptional Regulation;transcriptomics;United States National Institutes of Health;Variant;Work

PROJECT_TITLE: FUNCTIONAL CHARACTERIZATION OF NOVEL DETERMINANTS OF HOLOPROSENCEPHALY (HPE)

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


NIH_SPENDING_CATS: Clinical Research;Digestive Diseases;Genetics;Human Genome;Patient Safety;Prevention

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative Data suggest that a person’s genetic background influences his individual risk of developing diverticulitis. The proposed work will: 1) Determine if the genetic background can predict whether a patient will have a mild or severe course of diverticulitis; 2) Investigate whether abdominal obesity might change the impact of genetic background; and 3) Research a potential shared genetic causality between diverticulitis and other clinically related diseases. Knowledge gained from these studies could translate into meaningful advances for patients with diverticular disease.

PI_NAMEs: MAGUIRE, LILLIAS HOLMES (contact)

PROGRAM_OFFICER_NAME: PAWLIKOWSKA, LUDMILA SYLWIA

PROJECT_TERMS: Abdomen;Abdominal Abscess;Abdominal Pain;Adipose tissue;Admission activity;Alleles;Aneurysm;Architecture;biobank;Bioinformatics;Biological;career development;case-by-case basis;Central obesity;Chills;Clinical;clinical decision-making;clinical phenotype;cohort;Colectomy;Colon;Colorectal;Complex;Connective Tissue;cost;Data;Development;Development Plans;Diet;Disease;Disease stratification;Distress;Diverticulitis;Diverticulosis;Emergency department visit;Environmental Risk Factor;Epidemiology;Etiology;Fever;Foundations;gastrointestinal;Genes;Genetic;Genetic Determinism;Genetic Risk;genetic risk factor;genome wide association study;genomic epidemiology;genomic locus;genomic tools;Genomics;Goals;Health;Heritability;Hernia;high risk;Hospitalization;improved;Individual;Inpatients;Joint Dislocation;Knowledge;Lead;Link;Malaise;Master of Science;Measures;Medicine;Mentors;Mentorship;Mesenchymal Stem Cells;Michigan;modifiable risk;Morbidity - disease rate;Obesity;Operative Surgical Procedures;Outcome;Pathology;Patient Care;Patients;pelvic organ prolapse;Perforation;Performance;Peritonitis;Persons;phenome;Phenotype;Physicians;Polycystic Kidney Diseases;polygenic risk score;Polygenic Traits;Population;prevent;prospective;Ptosis;Radiology Specialty;Recurrence;Research;Research Personnel;Risk;Risk Factors;risk prediction;risk stratification;Role;Secondary Prevention;Sepsis;Severities;skills;Structure;Surgeon;tool;Training;trait;Translating;Twin Studies;United Kingdom;United States;Universities;Visceral;Visceral fat;Work

PROJECT_TITLE: Genetic Determinants of Outcomes in Diverticular Disease


ORG_CITY: BLOOMINGTON

ORG_DEPT: BIOLOGY

ORG_NAME: TRUSTEES OF INDIANA UNIVERSITY

ORG_STATE: IN

PHR: Project Narrative: The proposed research is relevant to public health and the mission of the NIH because Drosophila has been and continues to be a leading model organism to study fundamental biological processes and molecular and cellular mechanisms of human disease. The Drosophila Genomics Resource Center is a central repository and distribution center for genomic resources essential for research in Drosophila.

PI_NAMEs: ZELHOF, ANDREW  (contact)

PROGRAM_OFFICER_NAME: ZOU, SIGE

PROJECT_TERMS: aerobic glycolysis;Anterior;Applied Research;Archives;Behavior;Biological Models;Biological Process;Biomedical Research;Catalogs;cDNA Library;Cell Cycle;Cell Line;Cells;Cessation of life;Chromatin Modeling;Clinical Sciences;Collaborations;Communities;Complementary DNA;cost;Coupled;COVID-19 pandemic;CRISPR/Cas technology;Data;Data Management Resources;Development;Disease;Drosophila genome;Drosophila genus;Drosophila melanogaster;Epigenetic Process;Erinaceidae;Evolution;fundamental research;Funding Agency;gene conservation;Gene Expression Regulation;gene replacement;Genes;Genetic;Genome;genome resource;Genomics;Goals;Grant;Homeostasis;Homologous Gene;Human;human disease;improved;Indiana;Individual;Informatics;International;Link;Malignant Neoplasms;Meiosis;Metabolic;Metadata;Mission;Mitosis;model organism;Modeling;Molecular;Nerve Degeneration;neural;Neurobiology;neuroblast;notch protein;Pathway interactions;Pattern;Plasmid Cloning Vector;Population;preservation;Process;programs;Protocols documentation;Public Health;Quality Control;Reagent;Receptor Protein-Tyrosine Kinases;recombinase-mediated cassette exchange;Recovery;repository;Reproducibility;Research;Resources;RNA Interference;Scientist;sensor;Signal Pathway;Signal Transduction;Specific qualifier value;success;Synapses;Technology;Translational Research;United States National Institutes of Health;Universities;Update;vector;web interface;Work

PROJECT_TITLE: DROSOPHILA GENOMICS RESOURCE CENTER

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BTC-Y (55)]


PROJECT_TERMS: aerobic glycolysis;Anterior;Applied Research;Archives;Behavior;Biological Models;Biological Process;Biomedical Research;Catalogs;cDNA Library;Cell Cycle;Cell Line;Cells;Cessation of life;Chromatin Modeling;Clinical Sciences;Collaborations;Communities;Complementary DNA;cost;Coupled;COVID-19 pandemic;CRISPR/Cas technology;Data;Data Management Resources;Development;Disease;Drosophila genome;Drosophila genus;Drosophila melanogaster;Epigenetic Process;Erinaceidae;Evolution;fundamental research;Funding Agency;gene conservation;Gene Expression Regulation;gene replacement;Genes;Genetic;Genome;genome resource;Genomics;Goals;Grant;Homeostasis;Homologous Gene;Human;human disease;improved;Indiana;Individual;International;Link;Malignant Neoplasms;Meiosis;Metabolic;Metadata;Mission;Mitosis;Modeling;Nerve Degeneration;neural;Neurobiology;neuroblast;notch protein;Pathway interactions;Pattern;Plasmid Cloning Vector;Population;preservation;Process;programs;Protocols documentation;Quality Control;Reagent;Receptor Protein-Tyrosine Kinases;recombinase-mediated cassette exchange;Recovery;repository;Reproducibility;Research;Resources;RNA Interference;Scientist;sensor;Signal Pathway;Signal Transduction;Specific qualifier value;success;Synapses;Technology;Translational Research;United States National Institutes of Health;Universities;Update;vector;web interface;Work


PROJECT_TERMS: aerobic glycolysis;Anterior;Applied Research;Archives;Behavior;Biological Models;Biological Process;Biomedical Research;Catalogs;cDNA Library;Cell Cycle;Cell Line;Cells;Cessation of life;Chromatin Modeling;Clinical Sciences;Collaborations;Communities;Complementary DNA;cost;Coupled;COVID-19 pandemic;CRISPR/Cas technology;Data;Data Management Resources;Development;Disease;Drosophila genome;Drosophila genus;Drosophila melanogaster;Epigenetic Process;Erinaceidae;Evolution;fundamental research;Funding Agency;gene conservation;Gene Expression Regulation;gene replacement;Genes;Genetic;Genome;genome resource;Genomics;Goals;Grant;Homeostasis;Homologous Gene;Human;human disease;improved;Indiana;Individual;Informatics;International;Link;Malignant Neoplasms;Meiosis;Metabolic;Metadata;Mission;Mitosis;Modeling;Nerve Degeneration;neural;Neurobiology;neuroblast;notch protein;Pathway interactions;Pattern;Plasmid Cloning Vector;Population;preservation;Process;programs;Protocols documentation;Quality Control;Reagent;Receptor Protein-Tyrosine Kinases;recombinase-mediated cassette exchange;Recovery;repository;Reproducibility;Research;Resources;RNA Interference;Scientist;sensor;Signal Pathway;Signal Transduction;Specific qualifier value;success;Synapses;Technology;Translational Research;United States National Institutes of Health;Universities;Update;vector;web interface;Work


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Disability Research;Epilepsy;Gene Therapy;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurodegenerative;Neurosciences;Pediatric

ORG_CITY: NEW YORK

ORG_DEPT: NEUROLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: The proposed research serves public health through the development of therapeutics that could improve treatment and reduce disability for certain patients with neurodevelopmental disability resulting from pathogenic variants in KCNQ3. With the current standard of care, patients remain substantially impaired, non- verbal, and unable to care for themselves. The project is relevant to the NIH's mission because it is focused on improving the care of patients for whom no dedicated treatment currently exists.

PI_NAMEs: SANDS, TRISTAN T (contact)

PROGRAM_OFFICER_NAME: SPRIGGS, SHARDELL M

PROJECT_TERMS: Absence Epilepsy;Action Potentials;Address;adeno-associated viral vector;Affect;Alleles;Arginine;autism spectrum disorder;Axon;Behavior;Behavioral Assay;Caring;Cells;Central Nervous System;Clinical;clinical application;Codon Nucleotides;Data;Dedications;design;Development;disability;Disease;effective therapy;Fire - disasters;Future;gain of function;gene therapy;Generations;Genes;Goals;Homing;Human;human disease;Impairment;improved;In Vitro;in vivo;in vivo evaluation;Individual;Intellectual functioning disability;knock-down;Knock-in Mouse;Lead;Meninges;MicroRNAs;Missense Mutation;Mission;Modeling;Motor Seizures;mouse model;Neurodevelopmental Disability;Neurodevelopmental Disorder;Neurons;non-verbal;novel;Outcome Measure;overexpression;Pathogenicity;Patient Care;Patients;Phase;Phenotype;Population;pre-clinical;preclinical study;Public Health;pup;Recurrence;Reporting;Research;response;RNA Interference;RNA Interference Therapy;Safety;Sample Size;Specificity;standard of care;Structure of choroid plexus;symptom management;Syndrome;System;targeted treatment;Therapeutic;therapeutic development;therapeutic target;therapeutically effective;tissue tropism;Tissues;Toxic effect;translational applications;translational approach;Translations;Ultrasonics;United States National Institutes of Health;Variant;vector;Viral Vector;vocalization;Voltage-Gated Potassium Channel

PROJECT_TITLE: Therapeutic Targeting of KCNQ3 in KCNQ3 Gain-of-Function Disorder

STUDY_SECTION_NAME: Special Emphasis Panel[ZNS1 SRB-M (16)]


NIH_SPENDING_CATS: Autoimmune Disease;Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Complementary and Integrative Health;Digestive Diseases;Emerging Infectious Diseases;Infectious Diseases;Inflammatory Bowel Disease;Nutrition

ORG_CITY: COLLEGE STATION

ORG_NAME: TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR

PHR: Narrative Enteric diseases are among the most common human ailments. Conventional biologics are not suited for enteric applications due to their susceptibility to degradation in the protease-rich environment of the GI tract. This project will develop both a protease-stable scaffold that can be templated for engineering biologics for diverse enteric diseases and a probiotic yeast-based platform for in situ delivery of biologics to the GI lumen.

PI_NAMEs: CHEN, ZHILEI  (contact)

PROGRAM_OFFICER_NAME: RANALLO, RYAN

PROJECT_TERMS: Acceleration;Acute Diarrhea;adalimumab;Animal Model;Animals;Ankyrin Repeat;Antibiotics;Antibodies;Bacteria;Binding;Biological;Biological Products;Biological Response Modifier Therapy;Biomedical Engineering;Blood;Blood Circulation;Capsid Proteins;Cattle;Chronic diarrhea;chymotrypsin;Clostridium difficile;Code;Colostrum;Complementary DNA;Constipation;Coupled;Custom;design;Development;Diarrhea;diarrheal disease;Diffusion;Digestion;Directed Molecular Evolution;Disease;Drug Side Effects;Engineered Probiotics;Engineering;engineering design;Enteral;Environment;Escherichia coli;Exhibits;Food;Gastrointestinal tract structure;Generations;Health;Home;Hospitalization;Human;illness length;improved;In Situ;In Vitro;in vivo;Infection;infection risk;Inflammatory Bowel Diseases;Injections;Libraries;Link;Malignant Neoplasms;Mediating;Messenger RNA;Microbe;microorganism;Modeling;Mutation;novel;Oral;Patients;Peptide Hydrolases;Peptide Signal Sequences;Peptides;Persons;Phage Display;Pharmaceutical Preparations;Population;Positioning Attribute;preclinical development;Predisposition;Prevalence;prevent;Probiotics;promoter;Protein Secretion;Proteins;Reaction;Resistance;Ribonucleases;Ribosomes;scaffold;Scaffolding Protein;Sepsis;side effect;standard of care;Symptoms;synergism;Systemic disease;Technology;thermostability;Toxin;Trypsin;Variant;Viral;Virulent;Yeasts

PROJECT_TITLE: Engineering Biologics for treatment of enteric diseases

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-M (81)]


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

ORG_CITY: BOSTON

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: We know that metabolically active brown adipose tissue (BAT) is present in adult humans and burns energy for thermogenesis. The study is designed to evaluate the complex relationship between the intra-cellular and circulating thyroid hormone (TH) levels and BAT activity, transcriptome, and cellular composition to better understand the interaction between the thyroid axis and BAT in the process of thermogenesis in humans. Finding ways to stimulate BAT can lead to the development of new therapies for obesity and diabetes, which are major public health concerns.

PI_NAMEs: GAVRILA-FILIP, ALINA  (contact)

PROGRAM_OFFICER_NAME: BROWN, PATRICK

PROJECT_TERMS: adipocyte differentiation;Adipose tissue;Adult;Affect;animal data;Basal metabolic rate;Body Composition;Body fat;Body measure procedure;Brown Fat;Burn injury;Caring;Child;Clinical Research;Complex;design;Development;Diabetes Mellitus;Dual-Energy X-Ray Absorptiometry;Energy Metabolism;fasting glucose;Glycosylated hemoglobin A;Goals;Grant;Hour;Human;Indirect Calorimetry;Infant;Insulin;Life;Lipids;liquid chromatography mass spectrometry;Measures;Medical;Metabolic;Neck;novel therapeutic intervention;novel therapeutics;Obesity;obesity treatment;Operative Surgical Procedures;Oxidative Phosphorylation;Patients;PET/CT scan;Play;Positron-Emission Tomography;Process;Public Health;Publishing;Research;Role;Scanning;Schedule;single nucleus RNA-sequencing;subcutaneous;Testing;Thermogenesis;Thyroid Function Tests;Thyroid Gland;Thyroid Hormones;Thyrotropin;Time;Tissue Sample;transcriptome;United States National Institutes of Health;Visit;Writing;X-Ray Computed Tomography

PROJECT_TITLE: The Interaction Between the Thyroid Axis and Brown Adipose Tissue in Humans

STUDY_SECTION_NAME: Special Emphasis Panel[ZTR1 CI-5 (01)]


NIH_SPENDING_CATS: Cardiovascular;Genetics;Heart Disease

ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Narrative The goal of this multi-PI project is to develop a high-throughput discovery platform to characterize the function and pharmacology of voltage-gated sodium channels of defined subunit composition.

PI_NAMEs: AHERN, CHRISTOPHER A (contact);PIPER, ROBERT C

PROGRAM_OFFICER_NAME: BALIJEPALLI, RAVI C

PROJECT_TERMS: Action Potentials;Affect;Arrhythmia;Atrial Fibrillation;base;Biological Assay;Cardiac;Cell Line;Cell Size;Cells;Characteristics;Cholesterol;Clinical;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;Cultured Cells;Cytoplasm;Data;Defect;Development;Disease;disease-causing mutation;drug development;Drug Screening;effective therapy;Electrophysiology (science);Engineering;Ensure;Epilepsy;Exhibits;experimental study;Family;Family member;Gene Family;Genes;Goals;Haploid Cells;Heart;Heart Diseases;high throughput screening;Human;human disease;Immunoglobulins;indium arsenide;Individual;Inherited;instrument;Intervention;Ion Channel;ischemic injury;Life;Lipids;Mammalian Cell;Manuals;medication safety;member;Membrane;Modality;Molecular;Muscle;mutant;Mutation;Myocardium;novel therapeutics;Obesity;Outcome;Pain;patch clamp;Pathology;Performance;Pharmaceutical Preparations;pharmacologic;Pharmacology;prevent;Property;protein complex;Protein Isoforms;Proteins;Reperfusion Injury;Research;SCN1A protein;Sodium;Sodium Channel;Specificity;Structure;Sudden infant death syndrome;Syndrome;System;Testing;tool;trafficking;Transgenes;translational study;Variant;voltage;Xenopus oocyte

PROJECT_TITLE: Towards systematic analysis of cardiac voltage-gated sodium channel beta subunit function

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-O (O1)]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: WINSTON-SALEM

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative The project will examine the perceptions that 1st and 2nd generation Mexican immigrants hold regarding the benefits and drawbacks to receiving their epigenetic age. In addition, it will examine the response that participants have to receiving their epigenetic age test results among those who do so. Findings from this study may be useful as we seek to understand the degree to which people, including underrepresented minority populations, value receipt of epigenetic information

PI_NAMEs: SANDBERG, JOANNE CHRISTINE (contact)

PROGRAM_OFFICER_NAME: BANDIERA, FRANK

PROJECT_TERMS: accelerated epigenetic aging;Address;Adult;Age;Attitude;Awareness;Behavior;Belief;Biological;biological age;Biological Aging;Biomedical Research;Cardiovascular Diseases;cell type;Chronology;Clinical;Communities;Complex;Coronary heart disease;Country;Diet;Disease;DNA Methylation;Eating;Ensure;Epigenetic age;epigenetic aging;Epigenetic Process;epigenetic variation;epigenome;epigenomics;Exercise;Funding;Gene Expression;Generations;Genetic;genetic testing;Genome;Genomics;Genotype;good diet;Grant;Health;health equity;Hearing;histone modification;human old age (65+);Immigrant;improved;Individual;interest;Intervention;Interview;Interviewer;Knowledge;Latinx;Measurement;Medicine;Mexican;Minority;minority communities;Minority Groups;mortality;Non-Insulin-Dependent Diabetes Mellitus;Obesity;Parkinson Disease;Participant;Patients;Perception;Persons;Pilot Projects;Proteins;Reporting;Research;Resources;response;Risk;Sampling;smoking cessation;Structure;Technology;Test Result;Time;Transcript;Underrepresented Minority;Underrepresented Populations;underserved community;underserved minority;Underserved Population;uptake;Voice;young adult

PROJECT_TITLE: Attitudes about Return of Epigenetic Age Results among Latinx Adults

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 SEIR-S (80)]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Biomedical Imaging;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Neurodegenerative;Neurosciences;Prevention;Psychosis;Schizophrenia;Serious Mental Illness

ORG_CITY: BELMONT

ORG_NAME: MCLEAN HOSPITAL

PHR: PROJECT NARRATIVE Schizophrenia is a devastating psychiatric disorder that brings heavy burden to health care systems, associated with early aging, such as faster decline in cognitive functioning, increased risk for dementia, and significantly shorter life expectancies. Our goal in this project is to investigate neurobiological mechanisms and to explore in vivo biomarkers that capture unique neurobiological contributions of aging and disease course trajectory in schizophrenia.

PI_NAMEs: DU, FEI  (contact);ONGUR, DOST

PROGRAM_OFFICER_NAME: ROWLAND, LAURA

PROJECT_TERMS: Acceleration;Address;Affect;Age;age acceleration;Age Years;Aging;aging mechanism;Antioxidants;Antipsychotic Agents;ATP phosphohydrolase;ATP Synthesis Pathway;Automobile Driving;Biochemical;Bioenergetics;Biological Markers;Biology;Blood;Blood specimen;Blood Vessels;Brain;brain control;brain dysfunction;brain metabolism;Brain Pathology;Brain region;cardiometabolism;Cardiovascular Diseases;cerebral atrophy;Cerebrovascular Circulation;Chronic;Chronic Disease;Clinical;Clinical assessments;clinical phenotype;Cognition;Cognitive;cognitive function;cognitive testing;cohort;Cohort Effect;Communication;Communities;comparative;Creatine Kinase;Data;Data Set;Dementia;dementia risk;design;Development;Diabetes Mellitus;Disease;Distant;early psychosis;Energy Metabolism;Ensure;follow-up;functional decline;Functional disorder;Functional Magnetic Resonance Imaging;Future;gamma-Aminobutyric Acid;Glutamates;Glutathione;Glycolysis;Goals;Healthcare Systems;healthy aging;Hospitals;Image;Impaired cognition;Impairment;in vivo;Individual;Inflammatory;information processing;insight;interest;Intervention;late life;Lead;Life;Life Expectancy;life span;Life Style;Link;Literature;longitudinal design;Magnetic Resonance Imaging;Measures;Medial;Medical;Mental disorders;Metabolic;Metabolic syndrome;Metabolism;Mitochondria;Modality;Molecular;mortality;myoinositol;N-Methyl-D-Aspartate Receptors;NADH;National Institute of Mental Health;neurobiological mechanism;Neurobiology;neurochemistry;Neurodegenerative Disorders;neuroimaging;neuroinflammation;Neuronal Dysfunction;Neurons;novel;Obesity;Older Population;Oxidation-Reduction;Pathologic;pathological aging;Pathology;Pathway interactions;Patient Recruitments;Patients;Persons;Pharmaceutical Preparations;Phase;Phosphorus;Prefrontal Cortex;premature;Premature aging syndrome;Process;Protons;Psychoses;rate of aging;repaired;Research;response;Rest;Risk Factors;Risk Reduction;RNA Splicing;Role;Schizophrenia;schizophrenia spectrum disorder;sedentary lifestyle;sex;side effect;Smoking;Societies;structural imaging;Survivors;Symptoms;Tobacco smoking behavior;Toxic effect;treatment effect;Work

PROJECT_TITLE: Molecular Mechanisms of Aging in Schizophrenia: Implications of Bioenergetic Metabolism and Redox Biology

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-S (06)]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases;Orphan Drug;Rare Diseases;Tuberculosis

ORG_CITY: SEATTLE

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

ORG_STATE: WA

PHR: NARRATIVE The transporters that shuttle nutrients across the outer membrane of the bacterium that causes tuberculosis, Mycobacterium tuberculosis, are largely unknown. Here, we will test the role of the large PE/PPE protein family in nutrient transport.

PI_NAMEs: GRUNDNER, CHRISTOPH  (contact)

PROGRAM_OFFICER_NAME: ROBINSON, RICHARD THOMAS

PROJECT_TERMS: Address;Affect;Amino Acids;Bacteria;Binding;Biochemical;Biology;Capromycin;Cell Wall;Cells;combinatorial;Complex;CRISPR interference;Darkness;Data;Disease;Drug resistance;Drug resistant Mycobacteria Tuberculosis;Drug Transport;efflux pump;Family;Family member;Genes;Genetic;Genetic Code;Genome;Genomics;Genus Mycobacterium;Gram-Negative Bacteria;large datasets;Length;member;Membrane;Mutation;mycobacterial;Mycobacterium tuberculosis;Nutrient;pathogen;Pathogenicity;Permeability;Persons;Pharmaceutical Preparations;Physiology;Predisposition;Process;prolyl-proline;prolylglutamic acid;Protein Family;Proteins;Resistance;Role;Structure;Testing;transcriptome sequencing;Tuberculosis;tuberculosis drugs;uptake;VDAC1 gene;Water;Work

PROJECT_TITLE: Transporter function of the Mycobacterium tuberculosis PE/PPE proteins

STUDY_SECTION: PCMB

STUDY_SECTION_NAME: Prokaryotic Cell and Molecular Biology Study Section[PCMB]


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Disability Research;Intellectual and Developmental Disabilities (IDD);Machine Learning and Artificial Intelligence;Mental Health;Neurosciences;Pediatric

PHR: Narrative This project will develop “wearable” magnetoencephalography with synchronized movement video tracking for use in freely-moving children that will be used to elucidate the brain circuit activity which promotes intellectual development. The participants will be school-age children with typical development and with varying degrees of intellectual disability related to autism spectrum disorder. By defining the frequency bandwidths and brain locations of electrical activity coherence that promote intellectual development, the project will lay the essential groundwork for future therapies that will remediate intellectual disability in children.

PI_NAMEs: ROBERTS, TIMOTHY P;WELSH, JOHN P (contact)

PROGRAM_OFFICER_NAME: ANKUDOWICH, ELIZABETH

PROJECT_TERMS: Address;Adult;Association Learning;Auditory;Auditory area;auditory processing;autism spectrum disorder;autistic children;Behavioral;Blinking;Brain;Brain imaging;Child;Childhood;clinical application;Clinical assessments;clinical diagnostics;clinical research site;Cognition;Cognitive;cognitive function;conditioning;Data;deep learning algorithm;Development;Diagnosis;Diagnostic;Diagnostic tests;Electroencephalography;Electrophysiology (science);Ensure;Feedback;Frequencies;Functional disorder;Future;Human;Intellectual functioning disability;Intervention;kinematics;Laboratories;Language;Least-Squares Analysis;lexical;Limb structure;Location;Machine Learning;Magnetoencephalography;Measures;Medical;Motor;motor learning;Movement;Names;Nervous System Disorder;Neurodevelopmental Disorder;neuronal circuitry;neurophysiology;Neurosciences;neurotechnology;operation;optical imaging;Optics;Participant;Pediatric Hospitals;Pediatric Neurology;Phase;Philadelphia;Physiological;Physiology;Prognosis;Pump;remediation;Research;Research Institute;Resolution;response;Scanning;School-Age Population;Sensory;Signal Transduction;Site;success;System;Technology;Testing;Time;Universities;Variant;Washington;wearable device;Work

PROJECT_TITLE: Integrated movement tracking for pediatric OPM-MEG studies of intellectual disability

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-E (01)]


ADMINISTERING_IC: LM

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cardiovascular;Clinical Research;Complementary and Integrative Health;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Hypertension;Networking and Information Technology R&D (NITRD);Nutrition;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: LEXINGTON

ORG_DEPT: OTHER CLINICAL SCIENCES

ORG_NAME: UNIVERSITY OF KENTUCKY

PHR: The “"Meals that Heal" project will develop, disseminate, and evaluate a useful and usable interactive health information resource for low-income African American women and other economically-disadvantaged African Americans. The interactive resource book will provide tailored health information about hypertension risk reduction and the DASH diet [Dietary Approaches to Stop Hypertension], including culturally relevant and low-cost DASH recipes for hypertension disease prevention or management. The resource book will be marketed to a broader audience through existing community-based partnerships and networks.

PI_NAMEs: WHITE, BRANDI MICHELLE (contact)

PROGRAM_OFFICER_NAME: SMITH, CRISTAN

PROJECT_TERMS: Adherence;adherence rate;Adopted;Adult;Affect;African American;African American population;African American Women;American;Asian Women;Awareness;Behavioral;blood pressure reduction;Books;Budgets;built environment;Cardiac health;Cardiovascular Diseases;cardiovascular disorder risk;Communities;community-centered;Complex;cost;DASH diet;Decision Making;Diastolic blood pressure;Diet;Diet Modification;dietary;dietary adherence;dietary approach;Disease Management;disorder prevention;Disparity;Eating;economic disparity;Economics;Educational workshop;Effectiveness;effectiveness evaluation;evidence base;Family;Family member;Financial Hardship;Food;food insecurity;food quality;Goals;good diet;Government;healing;Health;Health Care Costs;health disparity populations;Health Food;Healthy Eating;Heart;high risk;Hispanic Women;Hypertension;hypertension control;hypertension prevention;improved;informant;Information Resources;innovation;Intervention;Interview;Knowledge;lifestyle intervention;Literature;Low income;Low Income Population;Marketing;Outcome;Pathway interactions;Peer Review;Persons;preference;prevent;Primary Prevention;Professional Organizations;Psychosocial Stress;Public Housing;Publications;racial discrimination;Recipe;Research;Research Project Grants;Resources;Risk;Risk Factors;Risk Reduction;Social Environment;social health determinants;Social support;socioeconomics;Subgroup;United States National Library of Medicine;usability;Woman

PROJECT_TITLE: DASH-ing to Heart Health: Supporting Low-Income African American Women with an Interactive "Meals that Heal" Resource Book

STUDY_SECTION_NAME: Special Emphasis Panel[ZLM1 ZH-G (01)]


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Breast Cancer;Cancer;Cervical Cancer;Clinical Research;Colorectal Cancer;Data Science;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Networking and Information Technology R&D (NITRD);Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Women's Health Research

ORG_CITY: CHARLESTON

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

PHR: PROJECT NARRATIVE This project will develop an interactive web-based tool and a toolkit for community organizations to communicate cancer disparities data in an easy-to-comprehend visual framework. The tool and the toolkit will strengthen cancer outreach efforts, programs, and policies by providing critical insights into unmet needs and inequities among low-income and underserved populations. Our long-term goal is to provide useful, usable, understandable health disparities data and form partnerships with community organizations and stakeholders to implement evidence-based resources and achieve cancer health equity.

PI_NAMEs: SONAWANE, KALYANI  (contact)

PROGRAM_OFFICER_NAME: YOON, SUNG SUG

PROJECT_TERMS: Address;Adherence;American Cancer Society;Area;Big Data;Breast;Breast Cancer Detection;Breast Cancer Early Detection;Cancer Burden;cancer care;Cancer Center;Cancer Control;cancer diagnosis;cancer epidemiology;cancer health disparity;Cancer health equity;cancer prevention;cancer therapy;care systems;Caring;Cervical;Cervical Cancer Screening;Cessation of life;Chronic;Colorectal;Colorectal Cancer;colorectal cancer screening;Communication;Communities;community engagement;community organizations;Community Outreach;Country;County;Data;data infrastructure;data integration;data visualization;Database Management Systems;Death Rate;Decision Making;Development;Diagnosis;Disease;Disparity;early screening;Economics;Evaluation Methodology;evidence base;Evidence based intervention;experience;Feedback;Goals;Health;health disparity;health disparity populations;Healthcare;improved;Individual;Inequity;Information Resources;Information Systems;innovation;insight;interactive tool;interactive visualization;Knowledge;Link;Low income;Low Income Population;Malignant Breast Neoplasm;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Medical;medically underserved;Medically Underserved Area;minority health;Mobile Health Units;Monitor;mortality;mortality disparity;National Cancer Institute;Online Systems;outreach;Patients;Policies;Policy Maker;Policy Making;Population;population health;Poverty;Poverty Areas;premalignant;Preventive care;Primary Care;programs;Public Health;Reporting;repository;Resource Allocation;Resources;Rural;rural underserved;screening;screening disparities;Screening for cancer;screening services;Services;social;Social Environment;sociodemographics;South Carolina;Strategic vision;Subgroup;Time;Time trend;tool;Translating;trend;underserved area;underserved community;Underserved Population;Universities;uptake;usability;Visual;Visualization;Visualization software;Vital Status;vulnerable community;Vulnerable Populations;web-based tool

PROJECT_TITLE: A Health Disparities Visualization Tool for Informing Cancer Prevention and Control Efforts


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Liver Disease;Nutrition

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Relevance to Public Health NALFD/NASH are the leading cause of chronic liver disease in the US, and therefore creates a significant burden to the national health system and there are limited options for treatments. Our discovery that altering bile acid selectively changes the absorption of different fatty acids will advance our fundamental understanding of how our bodies take up lipids from the diet, which is a significant contributor to NAFLD to NASH, and may reveal novel opportunities for therapeutic intervention.

PI_NAMEs: VALLIM, THOMAS A (contact)

PROGRAM_OFFICER_NAME: BURGESS-BEUSSE, BONNIE L

PROJECT_TERMS: absorption;adenovirus mediated delivery;Affect;Bile Acid Biosynthesis Pathway;bile acid metabolism;Bile Acids;Biological Assay;Cells;Cholecystokinin;Cholesterol;Cholic Acids;chronic liver disease;Clustered Regularly Interspaced Short Palindromic Repeats;Complement;Coupled;Data;design;Detergents;Diet;diet-induced obesity;dietary excess;Dietary Fats;Dietary Fatty Acid;Disease;Dose;Eating;Enterocytes;Enzymes;Fatty Acids;Fatty Liver;fatty liver disease;food consumption;GCG gene;Genes;Health system;Hepatic;Hormones;Hydrolysis;Image;imaging modality;In Vitro;in vivo;Individual;Inflammation;inhibitor;Intake;Intestinal Secretions;Intestines;Lipase;lipid biosynthesis;lipid metabolism;lipid transport;lipidomics;Lipids;Liver;Liver diseases;Liver Fibrosis;liver transplantation;Mass Fragmentography;Mass Spectrum Analysis;Measures;Mediating;Metabolic;Metabolism;Methods;Micelles;Molecular;Monounsaturated Fatty Acids;Mus;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;novel;novel therapeutic intervention;novel therapeutics;Nutrient;orlistat;Pathogenesis;Pathogenicity;Pathway interactions;Peptides;Physiological;Polyunsaturated Fatty Acids;prevent;Process;Public Health;receptor;Role;Saturated Fatty Acids;Signal Transduction;Signaling Molecule;System;Testing;Therapeutic Intervention;therapeutic target;Time;tool;Travel;Triglycerides;uptake;Visualization;Weight Gain;western diet

PROJECT_TITLE: Bile acid-mediated control of lipid absorption and fatty liver disease

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]