NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Nutrition;Obesity;Prevention;Social Determinants of Health

PROJECT_TERMS: Acids;Affect;Alanine;Amino Acids;Anion Gap;Basal metabolic rate;behavior prediction;Behavioral;Biological Markers;blood glucose regulation;Body Size;Body Weight Changes;Calories;Carbohydrates;Carbon Isotopes;Childhood;Clinical Trials;cold temperature;Collection;computerized;Consumption;Data;design;Desire for food;Devices;Diet;dietary;Dietary History;Dietary Practices;Dietary Proteins;Dopamine;Dose;Drops;Eating;energy balance;Energy Intake;Energy Metabolism;Equation;experience;Fasting;Fatty acid glycerol esters;Fatty Acids;fibroblast growth factor 21;Fishes;flexibility;Follow-Up Studies;Food;food insecurity;Food Selections;Fructose;Future;Genetic;Genotype;glucagon-like peptide 1;Goals;gut microbiome;Hair;Height;High Fat Diet;Hormonal;Hormones;Hour;Hyperphagia;Individual;Ingestion;Inpatients;Intake;Intervention;Leucine;Link;Lipids;Liquid substance;long chain fatty acid;Machine Learning;Macronutrients Nutrition;Measurement;Measures;Meat;Mediation;Metabolic;metabolic rate;Metabolism;metabolomics;Methods;Modeling;Monounsaturated Fatty Acids;Natural History;Nitrogen Isotopes;novel;obese person;Obesity;Obesity Epidemic;Outcome;Outpatients;oxidation;Participant;Pathway interactions;Pattern;Perception;Physiological;Plasma;preference;protective effect;Proteins;Psychosocial Factor;Questionnaires;Records;recruit;reduced food intake;Reproducibility;Residual state;respiratory;Rewards;Risk Factors;Role;Saline;Saturated Fatty Acids;Sensitivity and Specificity;Socioeconomic Status;soft drink;stable isotope;Sucrose;sugar;sweetened beverage;System;Temperature;Testing;Thinness;Thirst;thirst regulation;Threonine;Time;trial comparing;urinary;Variant;warm temperature;Water;Water consumption;Weight Gain;weight loss intervention;Work

PROJECT_TITLE: Regulators of Food Intake


ACTIVITY: ZIA

ADMINISTERING_IC: DK

ARRA_FUNDED: N

FUNDING_MECHANISM: INTRAMURAL RESEARCH

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: American Indian or Alaska Native;Clinical Research;Diabetes;Genetics;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Kidney Disease;Racial and Ethnic Minority Health Research

PI_NAMEs: HANSON, ROBERT  (contact)

PROJECT_TERMS: Albuminuria;American Indians;Blood specimen;Cardiovascular Diseases;Cell Line;Cholesterol;Collaborations;Complications of Diabetes Mellitus;Development;Diabetes Mellitus;Diabetic Nephropathy;Diabetic Neuropathies;Diabetic Retinopathy;DNA;DNA analysis;DNA Methylation;East Asian;epidemiology study;Ethnic Population;Family;Family Study;follow-up;Frequencies;Genetic;genetic association;Genetic Determinism;genetic epidemiology;genetic linkage;genetic pedigree;Genetic study;Genetic Techniques;genome wide association study;genome-wide;genome-wide analysis;genome-wide linkage;Genomic Segment;Genotype;Glucose Clamp;Hispanic Populations;Hyperinsulinism;Incidence;Indigenous American;Individual;Insulin Resistance;interest;Investigation;Kidney Diseases;Kidney Failure;Linkage Disequilibrium Mapping;lymphoblast;Maps;Measures;Methods;Micronesia;Morbidity - disease rate;Nuclear;Pacific Islander;peripheral blood;Pima Indian;Population;Predisposition;recruit;Renal function;Risk;sample collection;Sampling;segregation;Single Nucleotide Polymorphism;Susceptibility Gene;Techniques;trait;United States;Variant

PROJECT_TITLE: Genetic Epidemiology of Diabetic Complications


NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Clinical Research;Digestive Diseases;Genetics;Prevention;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

PI_NAMEs: WANK, STEPHEN  (contact)

PROJECT_TERMS: Ablation;Affect;Age of Onset;autosome;Biochemical;Biopsy;capsule;Carcinoid Tumor;carrier testing;cell regeneration;Cell Survival;Cells;chemotherapy;Clinical;clinical application;Collection;Colonoscopy;deep learning;Detection;Development;Diagnosis;Diagnostic;diagnostic screening;Diagnostic tests;Disease;Distal;DNA;effective therapy;Endocrine;Endoscopy;Enrollment;Enterochromaffin Cells;Epithelial Cells;Esophagogastroduodenoscopy;Evaluation;Excision;exome sequencing;Family;Family member;Family Study;follow-up;Gastrointestinal Carcinoid Tumor;Gene Mutation;Genes;Genetic;genetic analysis;genetic linkage analysis;Genotype;Germ Lines;Hereditary Malignant Neoplasm;histological specimens;Histology;human old age (65+);Image;imaging modality;Impairment;improved;Incidence;indexing;Individual;Inherited;Injury;inositol polyphosphate multikinase;Intention;intestinal epithelium;intestinal homeostasis;Intestinal Neuroendocrine Neoplasm;Intestines;kindred;Knowledge;Length;Lesion;lifetime risk;Location;Magnetic Resonance Imaging;Mediating;member;Metabolic;Methods;Modality;Morbidity - disease rate;mortality;Mucous Membrane;Mus;mutant;Mutate;Mutation;Natural History;neoplastic cell;Nuclear;Operative Surgical Procedures;Paneth Cells;Pathologic;Patients;PDPK1 gene;peripheral blood;Phenotype;Phosphorylation;Phosphotransferases;PIK3CG gene;Population;Primary Neoplasm;proband;Process;Prognostic Factor;Protein Truncation;Proteins;Proto-Oncogene Proteins c-akt;rare cancer;recruit;Recurrent disease;Reserve Stem Cell;Role;Sampling;Scanning;screening;Sensitivity and Specificity;Small Intestinal Carcinoid Tumor;Small Intestinal Neoplasm;Small Intestines;somatostatin analog;Specimen;stem cells;Survival Rate;Susceptibility Gene;Symptoms;Syndrome;Testing;tissue regeneration;TP53 gene;tumor;tumor DNA;tumorigenesis;X-Ray Computed Tomography

PROJECT_TITLE: Natural History of Familial Carcinoid Tumor


NIH_SPENDING_CATS: Congenital Structural Anomalies;Genetics;Pediatric;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human;Stem Cell Research - Nonembryonic - Non-Human

PI_NAMEs: GE, KAI  (contact)

PROJECT_TERMS: Acetylation;Acetyltransferase;Acute;Binding;cancer type;Cell Differentiation process;Cell Fate Control;cell type;Cells;Chromatin Remodeling Factor;cofactor;Complex;congenital heart abnormality;Data;Development;developmental disease;Embryonic Development;embryonic stem cell;Enhancers;EP300 gene;epigenomics;Feedback;Fingers;Gene Expression;gene induction;Genes;Genetic Transcription;Genets;Histones;ISWI;Kabuki Make-Up Syndrome;lipid biosynthesis;Malignant Neoplasms;Mammalian Cell;Mediating;Mediator;Methyltransferase;MLL gene;Modeling;mouse development;Mus;muscle regeneration;Mutate;myogenesis;novel;Nuclear Protein;Pathogenesis;Play;PPAR gamma;protein complex;Proteins;Reader;recruit;Regulation;RNA Polymerase II;Role;stem cells;Tissues;transcription factor;Transcriptional Regulation;Tumor Suppression

PROJECT_TITLE: Enhancer regulation by H3K4 methyltransferase KMT2D/MLL4 and associated factors


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Bioengineering;Clinical Research;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Nutrition;Obesity;Prevention;Racial and Ethnic Minority Health Research

PI_NAMEs: MUNIYAPPA, RANGANATH  (contact)

PROJECT_TERMS: Address;Adipocytes;Adult;adult obesity;Affect;African;African American population;African ancestry;American;Behavioral;Beta Cell;biobank;biobehavior;Blood;Blood Glucose;Blood specimen;Body Composition;Body mass index;Body Weight;Body Weight decreased;cardiovascular health;Cell Physiology;Child;Chronic;clinical center;Clinical Research;Closure by clamp;Coin;Collaborations;Communities;comorbidity;Consumption;Degenerative polyarthritis;design;Deuterium;Development;Diabetes Mellitus;diabetes risk;Eating;Eating Behavior;economic impact;Economics;Education;Energy Metabolism;Enrollment;epidemiology study;Ethnic Origin;euglycemia;European;Evaluation;exome sequencing;Fasting;Fatty acid glycerol esters;food marketing;Fostering;Functional disorder;Gastric Inhibitory Polypeptide;Gene Expression;genetic testing;glucagon-like peptide 1;Glucose;Glucose Clamp;glucose disposal;glucose production;Health;healthy volunteer;Heart Diseases;Hepatic;high risk;Hispanic Populations;Homeostasis;Human;Hyperglycemia;Hyperinsulinism;Hypertension;Impairment;improved;incretin hormone;indexing;Individual;Inflammation;Infusion procedures;Insulin;Insulin Resistance;insulin secretion;insulin sensitivity;Intervention;Intervention Studies;Intestinal Hormones;Intestinal Secretions;Intravenous;intravenous glucose tolerance test;islet;Life Expectancy;Liver diseases;Magnetic Resonance Spectroscopy;Malignant Neoplasms;mathematical model;Measurement;Measures;Mental Depression;Metabolic;Metabolism;Methodology;Methods;Modeling;multidisciplinary;Muscle;Natural History;non-diabetic;Non-Insulin-Dependent Diabetes Mellitus;obese person;Obesity;OGTT;Oral;Overweight;patient oriented research;Patients;Persons;Phenotype;Physical activity;Plasma;Policies;Population;Prediabetes syndrome;Predictive Value;Predisposing Factor;Procedures;Protocols documentation;Public Opinion;Race;recidivism;Relapse;Reporting;Research;Resources;response;Risk Factors;Sleep Apnea Syndromes;South Asian;Specimen;stable isotope;Stroke;Structure of beta Cell of islet;Techniques;Testing;Time;Tissue Sample;Tracer;trait;translational study;United States;United States National Institutes of Health;Urinary Incontinence;Urine;Variant;volunteer;Weight

PROJECT_TITLE: Biobehavioral Studies of Obesity, Weight loss and Recidivism


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Hematology;Liver Disease;Primary Immunodeficiencies;Rare Diseases;Sickle Cell Disease

PI_NAMEs: HELLER, THEO  (contact)

PROJECT_TERMS: Affect;Anatomy;Biology;Blood Platelets;Body System;Bone Marrow Transplantation;Case Series;Case Study;Categories;Chronic;Chronic Granulomatous Disease;Cirrhosis;Clinic;Clinical;clinical center;clinically relevant;cohort;Collaborations;congenital hepatic fibrosis;Consult;Data Collection;Development;Disease;Disease Progression;drug induced liver injury;end stage liver disease;gallin;Genetic Diseases;graft vs host disease;Hematological Disease;Hepatic;Hyperplasia;individual patient;Infection;Injury;interest;Investigation;Iron Overload;Knock-out;Knowledge;Laboratories;Lesion;Liver;liver biopsy;liver development;Liver diseases;liver hyperplasia;Manuscripts;model development;Modeling;mortality;Mortality Determinants;Mutation;National Heart, Lung, and Blood Institute;National Institute of Allergy and Infectious Disease;Natural History;neutrophil;pathogen;Patients;Portal Hypertension;Production;Protocols documentation;Publishing;regenerative;Reporting;Research;Respiratory Burst;Risk;Safety;sample collection;Services;Sickle Cell;Sickle Cell Anemia;Study models;Syndrome;System;Systemic disease;Time;United States National Institutes of Health;Viral hepatitis;Work

PROJECT_TITLE: Investigation of non-cirrhotic portal hypertension.


NIH_SPENDING_CATS: Cancer;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Genetics;Hepatitis;Hepatitis - C;Infectious Diseases;Liver Cancer;Liver Disease;Microbiome;Prevention;Rare Diseases

PI_NAMEs: GHANY, MARC  (contact)

PROJECT_TERMS: Address;Aftercare;Anti-Inflammatory Agents;Anti-viral Agents;Anti-viral Therapy;Ascites;B-Cell Lymphomas;Bacteria;Biopsy Specimen;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;Cause of Death;Cells;Cholesterol;Chronic;Chronic Hepatitis C;chronic infection;Cirrhosis;Clinical;cohort;Collaborations;COVID-19 pandemic;Detection;Development;Diabetes Mellitus;dysbiosis;Dyslipidemias;Environmental Risk Factor;Extrahepatic;Fasting;fatty acid biosynthesis;Fibrosis;follow-up;General Population;Genetic Polymorphism;genetic predictors;Genotype;gut microbiome;gut microbiota;Hemorrhage;Hepatic;Hepatic Encephalopathy;Hepatitis C;Hepatitis C virus;Hepatocyte;Human;Incidence;Individual;Interferons;Intestines;Life Cycle Stages;Lipids;Lipoproteins;Liver;liver biopsy;Liver diseases;Liver Fibrosis;liver inflammation;Low-Density Lipoproteins;Malignant Neoplasms;Mediating;Metabolism;microbial;microbiome;Monitor;mortality;Natural History;novel marker;Outcome;particle;pathobiont;Pathogenesis;Pathway interactions;Patient Participation;Patient-Focused Outcomes;Patients;Peritonitis;Persons;Play;Primary carcinoma of the liver cells;prospective;Proteins;Public Health;response;Risk;Role;Serum;Time;United States;Variant;Viral;viral RNA

PROJECT_TITLE: Natural History, Therapy and Pathogenesis of Chronic Viral Hepatitis C


NIH_SPENDING_CATS: American Indian or Alaska Native;Diabetes;Genetics;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Kidney Disease;Nutrition;Obesity;Racial and Ethnic Minority Health Research

PI_NAMEs: BAIER, LESLIE J (contact)

PROJECT_TERMS: 6-Phosphofructo-2-kinase;Acute;Adipose tissue;Adult;Affect;Alleles;American Indians;Atrophic;Basal metabolic rate;Beta Cell;Binding;Binding Sites;Biological;Biological Assay;Biopsy;Body fat;Body mass index;Caucasians;CCAAT-Enhancer-Binding Proteins;CDKN1C gene;Cell Line;cell type;Cells;Childhood;Cholesterol;Code;cohort;Collaborations;Communities;Complications of Diabetes Mellitus;CRISPR/Cas technology;Custom;Data;Databases;design;Diabetic Nephropathy;Disease;Energy Metabolism;Ethnic Population;Expenditure;falls;Fasting;follow-up;Follow-Up Studies;Frequencies;Fructose;Gender;Gene Cluster;Gene Expression;Gene Frequency;gene-editing approach;Genes;Genetic study;Genetic Transcription;genetic variant;genome wide association study;genome-wide;genomic data;genomic variation;Genotype;Genotype-Tissue Expression Project;Glucocorticoid Receptor;Glucocorticoids;glucose metabolism;Hepatic;High Prevalence;Human;in silico;Indigenous;indigenous community;Individual;Inpatients;Insulin;insulin secretion;Introns;Kidney;kidney biopsy;Kidney Glomerulus;Knock-out;Leukemic Cell;Linkage Disequilibrium;Liver;Low-Density Lipoproteins;Luciferases;manufacture;Maps;Measures;Meta-Analysis;Metabolic;metabolic rate;Minor;Mus;Muscle;muscle form;Muscular Atrophy;non-diabetic;Non-Insulin-Dependent Diabetes Mellitus;NR3C1 gene;Obesity;Persons;Phenotype;Physiological;Pima Indian;Plasma;Population;promoter;Protein Isoforms;Quantitative Trait Loci;Reporting;Resistance;response;Reverse Transcriptase Polymerase Chain Reaction;Risk;risk variant;RNA Splicing;Role;Sampling;scaffold;Signal Transduction;Site;Skeletal Muscle;Southwestern United States;System;Time;Tissue Sample;Tissues;trait;transcription factor;Tribes;Tyrosine 3-Monooxygenase;urban Native American;Variant;ventilation;whole genome;Y Chromosome

PROJECT_TITLE: Follow-Up Studies of a Genome-Wide Association Analysis in Pima Indians


NIH_SPENDING_CATS: Cancer;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Genetics;Hepatitis;Liver Cancer;Liver Disease;Nutrition;Obesity;Orphan Drug;Prevention;Rare Diseases

PI_NAMEs: ROTMAN, YARON  (contact)

PROJECT_TERMS: Adipose tissue;Adult;Affect;Agonist;Alleles;Animal Model;Biological Assay;Breath Tests;Carbohydrates;cell injury;Cell model;Cirrhosis;clinical center;clinical predictors;Clinical Trials;cohort;Collaborations;Comparative Study;comparison control;density;Development;Devices;Diglycerides;Disease;Drug Industry;Early identification;Eating;effective therapy;Effectiveness;end stage liver disease;Energy Metabolism;Enrollment;Enzymes;Fatty acid glycerol esters;fatty acid oxidation;Fatty Acids;Fatty Liver;Fibrosis;Food Energy;Functional disorder;Genes;genetic association;Genetic study;genetic variant;GLP-I receptor;healthy volunteer;Hepatic;Hepatocyte;high risk;Histologic;Human;human subject;Hydroxysteroid Dehydrogenases;improved;in vivo;Individual;Inflammation;Ingestion;Injury;insulin signaling;interest;intrahepatic;Knockout Mice;Label;lipidome;lipidomics;Lipids;Lipodystrophy;Liquid substance;Liver;Liver diseases;liver injury;liver transplantation;loss of function;Malignant neoplasm of liver;Metabolic;Metabolic dysfunction;Morbidity - disease rate;mortality;mouse model;National Institute of Diabetes and Digestive and Kidney Diseases;Natural History;new therapeutic target;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;novel therapeutics;Nutrient;Obesity;Oral;Overweight;particle;Pathogenesis;Pathway interactions;Patients;pediatric patients;Persons;Phenotype;Physiological;Physiology;Plasma;Population;Proteins;response;Role;Sampling;Severities;Single Nucleotide Polymorphism;Steatohepatitis;Structure;Study models;therapeutic target;Time;transcriptomics;United States;United States National Institutes of Health

PROJECT_TITLE: Nonalcoholic Steatohepatitis: Natural History, Pathogenesis and Therapy


NIH_SPENDING_CATS: Genetics;Human Genome;Obesity

PROJECT_TERMS: Acceleration;Adipocytes;Adipose tissue;Binding;Brown Fat;CCAAT-enhancer-binding protein-delta;cell growth;Cells;Chromatin;Chromatin Remodeling Factor;conditional knockout;CREB1 gene;Data;Defect;Development;Diabetes Mellitus;EGR2 gene;Enhancers;epigenome;epigenomics;gene induction;Genes;genomic profiles;Glucocorticoid Receptor;Histone H3.3;histone methylation;Histones;Hour;Impairment;in vivo;ISWI;Knock-in Mouse;Knock-out;Knockout Mice;Ligands;lipid biosynthesis;Literature;Mediating;Methyltransferase;MLL gene;MLL2 gene;Molecular Chaperones;Morbidity - disease rate;mortality;Mus;Muscle Development;mutant;myogenesis;Non-Insulin-Dependent Diabetes Mellitus;Obesity;Phase;Phosphorylation;Play;postnatal;PPAR gamma;precursor cell;promoter;Proteins;Reader;Regulation;Reporting;Repression;Resources;Risk Factors;RNA Polymerase II;Role;Site;SWI/SNF Family Complex;transcription factor;transcriptome

PROJECT_TITLE: Epigenomic regulation of adipogenesis and adipose expansion


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Genetics;Mental Health;Neurosciences;Obesity;Substance Misuse;Urologic Diseases

PI_NAMEs: WESS, JURGEN  (contact)

PROJECT_TERMS: Acetylcholine;Alpha Cell;Alzheimer's Disease;Animals;Area;Behavioral;Bladder;Body Weight;cell type;cholinergic;Collaborations;Cre-LoxP;detrusor muscle;Development;Disease;Drug Addiction;drug seeking behavior;Endowment;Enteroendocrine Cell;Food Intake Regulation;G-Protein-Coupled Receptors;Gene Targeting;Genes;Glucagon;Glucose;Goals;Homeostasis;Hypothalamic structure;Individual;insulin secretion;Kidney;Knock-out;Knockout Mice;Learning;Ligands;locomotor control;Mediating;member;Memory;Mental Depression;Metabolic;Moods;Muscarinic Acetylcholine Receptor;Muscarinic Agonists;Muscarinics;Muscle Contraction;mutant;Mutant Strains Mice;Nerve;Neurons;new therapeutic target;Non-Insulin-Dependent Diabetes Mellitus;novel;obesity treatment;Outcome Study;Overactive Bladder;Parkinson Disease;Peripheral;Pharmaceutical Preparations;Phenotype;Physiological;Physiology;Play;Process;Publishing;Regulation;response;Role;Schizophrenia;Sensory;Signal Pathway;Signal Transduction;Site;small molecule;Structure of beta Cell of islet;targeted treatment;Technology;therapeutic target;Tissues;transmission process;Urination;Work

PROJECT_TITLE: Muscarinic acetylcholine receptor subtypes: physiological roles


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Coronaviruses;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Influenza;Pneumonia and Influenza

PI_NAMEs: BAX, ADRIAAN  (contact)

PROJECT_TERMS: 2019-nCoV;Affect;alpha helix;Attenuated;Binding;biophysical techniques;Capsid Proteins;Cell fusion;Cell membrane;Cells;Cryoelectron Microscopy;Data;design;Detergents;Ebola;Equilibrium;Hemagglutinin;HIV-1;in silico;Influenza;influenzavirus;inhibitor;Lipids;Mediating;Membrane;Membrane Fusion;Micelles;Modeling;Molecular;Mutation;NMR Spectroscopy;Pathogenicity;Property;Proteins;Resolution;Roentgen Rays;SARS-CoV-2 B.1.1.529;SARS-CoV-2 spike protein;Site;Structure;Tertiary Protein Structure;Transmembrane Domain;transmission process;Variant;Viral;Viral Fusion Proteins;Virus;Water

PROJECT_TITLE: Structural study of the HIV1 gp41 coat protein


NIH_SPENDING_CATS: Bioengineering;Nanotechnology

PI_NAMEs: TYCKO, ROBERT  (contact)

PROJECT_TERMS: Adopted;Aluminum Oxide;Amino Acid Sequence;Amino Acids;Amyloid;aqueous;Area;Bee Venoms;Behavior;beta pleated sheet;Binding Proteins;biophysical properties;Biophysics;C-terminal;Chemicals;Cryoelectron Microscopy;Data;density;Development;Diameter;Electron Microscopy;Environment;Eukaryotic Cell;experimental study;flexibility;Freezing;Glutamine;Goals;Hydration status;Hydrogels;Individual;Isotope Labeling;Journals;Label;Length;Ligation;Liquid substance;Measurement;Membrane;Methods;mimetics;Modeling;Mole the mammal;Molecular Conformation;Molecular Structure;monomer;nano;nanopore;Neurodegenerative Disorders;Nuclear Pore;Organelles;Paper;Peptides;Phase;phosphonate;Physical condensation;Population;Population Distributions;Pore Proteins;Property;Proteins;Publications;Recombinants;RNA;RNA Processing;RNA Transport;RNA-Binding Protein FUS;Sampling;self assembly;Series;Signal Transduction;solid state nuclear magnetic resonance;Structure;Surface;synthetic peptide;System;Temperature;Tertiary Protein Structure;Transition Temperature

PROJECT_TITLE: Structural and Biophysical Properties of Low Complexity Proteins


NIH_SPENDING_CATS: Cooley's Anemia;Genetics;Hematology;Human Genome;Rare Diseases;Sickle Cell Disease;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

PI_NAMEs: DEAN, ANN  (contact)

PROJECT_TERMS: Address;Adult;Affect;Architecture;beta Globin;beta Thalassemia;Binding;cardiogenesis;Cell Differentiation process;Cell Lineage;cell type;Cells;Chromatin;Chromatin Loop;chromatin remodeling;Chromatin Structure;Chromosome Territory;Chromosomes;Complex;conditional knockout;Development;Disease;Elements;embryonic stem cell;enhancer binding protein;Enhancers;Epigenetic Process;Erythroid;Erythroid Cells;Family;Fetal Hemoglobin;GATA1 gene;Gene Activation;Gene Expression;Gene Family;gene repression;Genes;Genetic Diseases;Genetic Transcription;Genome;Globin;Goals;Health;Hematopoiesis;Hematopoietic;Hemoglobin;Hemoglobinopathies;histone modification;Histones;Homologous Gene;Human;human disease;insight;Knock-out;LIM Domain;LMO2 gene;Locus Control Region;Malignant Neoplasms;Meta-Analysis;MLL gene;Mus;Mutation;neurogenesis;Nuclear;Nucleic Acid Regulatory Sequences;Pathway interactions;Pattern;Play;Process;promoter;Property;Proteins;recruit;Regulation;Research;retinogenesis;RNA;Role;Sickle Cell Anemia;Specificity;TAL1 gene;Therapeutic;Tissues;transcription factor;Transcriptional Activation;transcriptome

PROJECT_TITLE: Chromatin Structure, Epigenetic and Developmental Regulation of Mammalian Gene


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Digestive Diseases;Genetics;Human Genome;Pancreatic Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Embryonic - Human

PI_NAMEs: AGARWAL, SUNITA  (contact)

PROJECT_TERMS: accurate diagnosis;Achievement;Adipocytes;Amino Acids;Benign;Biological Assay;Biological Models;Biological Process;C-terminal;Cancer Patient;CDK6-associated protein p18;CDKN2A gene;Cell Cycle;Cell Cycle Progression;Cell Cycle Regulation;Cell Line;Cell Proliferation;cell transformation;cell type;Cells;ChIP-seq;chromatin isolation by RNA purification sequencing;Cosmetics;Cyclin-Dependent Kinase Inhibitor;Cyclin-Dependent Kinase Inhibitor Gene;Data;Defect;Derivation procedure;Detection;differentiation in vitro;disease model;DNA Methylation;Down-Regulation;Duodenum;embryonic stem cell;Endocrine;Endocrine Gland Neoplasms;Enhancers;Epigenetic Process;Ethnic Origin;Event;exome sequencing;Family;follower of religion Jewish;GCM2 gene;Gene Cluster;Gene Expression;Gene Expression Microarray Analysis;Gene Family;Gene Mutation;Genes;Genetic Transcription;Genetically Engineered Mouse;genome sequencing;genome-wide;genome-wide analysis;genomic locus;Genomic Segment;Germ Lines;Germ-Line Mutation;gland development;Goals;Heterozygote;Histone H3;histone methylation;histone modification;Homeostasis;Human;Hyperparathyroidism;imaging modality;Inherited;insight;insulinoma;interest;islet;Islet Cell Tumor;Islets of Langerhans;kindred;Knock-in Mouse;Knockout Mice;Lead;Lipoma;Loss of Heterozygosity;Lysine;malignant parathyroid gland tumor;Maps;Menin;MET gene;Methylation;methylome;Molecular;Molecular Genetics;Mouse Embryonic Stem Cells;mouse model;Multiple Endocrine Neoplasia Type 1;Mus;Mutation;Neoplasms;Neuroendocrine Tumors;novel;novel strategies;Null Lymphocytes;Pancreas;Parathyroid Adenoma;Parathyroid gland;Parathyroid Neoplasms;Pathway interactions;Patients;Phenotype;Pheochromocytoma;Pituitary Neoplasms;positional cloning;Primary Cell Cultures;programs;Prolactin;Proliferating;protein complex;Proteins;Proto-Oncogenes;Regulation;Reporter;Risk Assessment;Role;Small Intestines;Somatic Mutation;Specimen;Syndrome;Tissues;tumor;tumor DNA;tumor initiation;tumor progression;Tumor Suppressor Proteins;tumorigenesis;Untranslated RNA;Up-Regulation;Variant;venous thromboembolism;Work

PROJECT_TITLE: Genes associated with endocrine tumorigenesis


NIH_SPENDING_CATS: Genetics

PI_NAMEs: YANG, WEI  (contact)

PROJECT_TERMS: ATP phosphohydrolase;base;Binding;Biochemical;biophysical properties;Cells;chemotherapy;Cisplatin;Complex;Data;Deamination;Detection;dimer;DNA;DNA Adducts;DNA lesion;DNA Repair;DNA-Directed RNA Polymerase;endonuclease;ERCC3 gene;Excision;Excision Repair;helicase;Individual;Intervention;Label;Lesion;Molecular;Molecular Conformation;Nuclear Extract;Nucleotide Excision Repair;Oligonucleotides;overexpression;plasmid DNA;Plasmids;Postdoctoral Fellow;Process;protein purification;Protein Subunits;Proteins;Publications;Reaction;reconstitution;recruit;Repair Complex;Research;Resolution;Series;SS DNA BP;Structure;transcription factor TFIIH;UV induced;Work;Writing;XPA gene

PROJECT_TITLE: Biophysical characterization of DNA repair complex TFIIH


PI_NAMEs: KIMMEL, ALAN R (contact)

PROJECT_TERMS: 3' Untranslated Regions;Adhesions;Affinity;Affinity Chromatography;Anabolism;Back;Bacteria;beta pleated sheet;Binding;Binding Proteins;Biochemical;Biological Assay;Biological Process;Calcium;Calpain;Cardiovascular Diseases;Cell Adhesion;Cell Aggregation;Cell Communication;Cell Density;cell growth;cell motility;Cell Physiology;Cells;cellular development;Cellularity;Characteristics;Chemotactic Factors;Chemotaxis;cofactor;Communication;Complex;Coupled;Coupling;Cues;Cyclic AMP;Cyclic AMP Receptors;Cytoplasm;Data;Deamination;density;Derivation procedure;desensitization;Development;Dictyostelium;Dimerization;directional cell;Dominant-Negative Mutation;Dose;Elements;Ensure;Epidermal Growth Factor;Epidermal Growth Factor Receptor;Eukaryota;Eukaryotic Cell;Event;Exhibits;experimental study;Family;Family member;Fatty Liver;Feedback;folate-binding protein;Folic Acid;Foundations;G Protein-Coupled Receptor Signaling;G-Protein-Coupled Receptors;Gene Expression;Gene Silencing;Genes;Genetic;Genetic Transcription;Genomics;Growth;Growth and Development function;GTP-Binding Proteins;Heterocyclic Compounds;Heterodimerization;Homeostasis;Homo;human disease;Image;Individual;Insulin Resistance;Integral Membrane Protein;interest;Kinetics;Length;Ligands;Lipid Mobilization;Lipids;mammalian genome;Mammals;MAPK1 gene;Mass Spectrum Analysis;Mediating;member;Membrane;Messenger RNA;Metabolic;Metabolic Diseases;Modeling;Molecular;Molecular Conformation;molecular modeling;Monitor;Mouse Strains;Movement;mRNA Stability;mutant;Mutate;Mutation;Natural Immunity;novel;Null Lymphocytes;Nutrient;Nutrient Depletion;Organelles;Organism;overexpression;Pathway interactions;Pattern;Peptide Hydrolases;perilipin;Periodicals;Phagocytes;Phenocopy;Phenotype;Phosphorylation;Phosphotransferases;Play;Population;posttranscriptional;preference;Process;Prokaryotic Cells;Property;protein complex;Protein Secretion;Protein Sequence Analysis;Proteins;Pterins;receptor;Receptor Activation;receptor binding;receptor function;Receptor Signaling;recruit;Regulation;Research;Resistance;response;Risk Factors;RNA Binding;RNA Splicing;RNA Stability;Role;scaffold;self organization;Sequence Deletion;Series;Signal Pathway;Signal Transduction;Site;Source;Starvation;steroid hormone;Surface;System;Territoriality;three-dimensional modeling;TIS11 protein;Tissues;Totipotent cell;trafficking;Transcript;Transcription Process;transcriptome sequencing;Translational Repression;Transmembrane Domain;Up-Regulation;Variant

PROJECT_TITLE: SIGNALING PATHWAYS IN CONTROL OF GROWTH AND DEVELOPMENT


NIH_SPENDING_CATS: Biotechnology;Congenital Structural Anomalies;Eye Disease and Disorders of Vision;Genetics;Kidney Disease;Neurodegenerative;Pediatric;Polycystic Kidney Disease;Rare Diseases

PI_NAMEs: GERMINO, GREGORY  (contact)

PROJECT_TERMS: Address;Affect;anterior chamber;Autosomal Dominant Polycystic Kidney;Autosomal Recessive Polycystic Kidney;Binding;Biological Models;Brain;Cell Culture System;Cells;Clinical;Collection;combinatorial;Cystic Kidney Diseases;Dedications;Development;Diameter;Disease;disease model;End stage renal failure;Eye;gene function;Gene Modified;Genes;Genetic;genome wide association study;Hereditary Disease;Human;Hydrophthalmos;in vivo;Individual;insight;interest;Intervention;Kidney;Laboratories;Length;Life;Link;Maintenance;Manuscripts;Methods;Molecular;Morphology;Mus;Mutant Strains Mice;Mutate;Nephrons;novel therapeutics;Open-Angle Glaucoma;Organ;Organoids;Pathogenesis;Phenotype;Polycystic Kidney Diseases;Preparation;Process;Proprotein Convertase 1;Proprotein Convertase 2;Proteins;Publishing;Renal function;Renal tubule structure;Reporting;Reproducibility;response to injury;Role;Sampling;Sequence Deletion;Severity of illness;Signal Pathway;Structure;System;Testing;Tubular formation;United States;Update;Variant

PROJECT_TITLE: The role of PKD proteins in regulating tubular morphology


PROJECT_TERMS: Affect;Area;base;BMI1 gene;Bromodeoxyuridine;Cell Differentiation process;Cell division;Cell Lineage;cell motility;Cells;Classification;Data;Development;Developmental Process;Distal;Duodenum;Endocrine;Enterochromaffin Cells;Enteroendocrine Cell;Ephrins;Epithelial Cells;Epithelium;epithelium regeneration;Erinaceidae;Gastrointestinal tract structure;Genetic Induction;Genetic Markers;Genetic Models;Goals;Homeostasis;Hormones;Human;ileum;In Situ Hybridization;In Vitro;in vivo;insight;interest;intestinal crypt;intestinal epithelium;Intestinal Neuroendocrine Neoplasm;Intestines;Ions;Label;LGR5 gene;Location;Maintenance;Mediating;Mesenchyme;Methods;Microscopic;migration;Mitochondrial DNA;Mitotic spindle;Modeling;Molecular;Monitor;Morphology;Mucous Membrane;Mus;Mutation;Neurons;Neurosecretory Systems;notch protein;novel;Organ;Organoids;Paneth Cells;Pathologic;Patients;Pattern;peptide hormone;Population;Positioning Attribute;precursor cell;Predisposition;Process;Property;Reporting;Reserve Stem Cell;RNA;Role;self-renewal;Signal Pathway;Small Intestinal Neoplasm;Small Intestines;Space Perception;stem cell biomarkers;stem cell division;stem cell genes;stem cell niche;stem cell population;stem cells;stemness;System;Tissues;transcription factor;tumor;tumorigenesis;Villus;WNT Signaling Pathway;Work

PROJECT_TITLE: Presence and role of Enteroendocrine Cells Residing at the Intestinal Crypt Base


PI_NAMEs: WEINSTEIN, LEE  (contact)

PROJECT_TERMS: Acute;adiponectin;Adipose tissue;Agonist;Alleles;Biochemical;cardiovascular effects;Central Nervous System;Chondrocytes;Collaborations;Cyclic AMP;Defect;diet-induced obesity;early-onset obesity;Eating;energy balance;Energy Metabolism;Enterobacteria phage P1 Cre recombinase;Enzymes;extracellular;Genes;Germ Lines;glucose metabolism;Goals;GTP-Binding Proteins;Hormones;Human;Hyperphagia;Hypothalamic structure;hypothalamic-pituitary-adrenal axis;In Vitro;in vivo;Knock-out;Knockout Mice;Liver;LoxP-flanked allele;Mediating;Melanocortin 4 Receptor;Melanocortin 4 receptor mutation;melanocortin receptor;Metabolic;Morbid Obesity;Mus;mutant;Mutation;Neurotransmitters;Obesity;paraventricular nucleus;Pathway interactions;Peripheral;Phenotype;Phospholipase C;Play;promoter;Property;receptor;Receptor Inhibition;Receptor Signaling;Regulation;Resistance;Role;Signal Transduction;Tissues;Transgenes;Transgenic Mice;Transgenic Organisms;transmission process;virtual

PROJECT_TITLE: Role of Gq/11-alpha in metabolic regulation


PI_NAMEs: REITMAN, MARC L (contact)

PROJECT_TERMS: Ablation;Acute;Affinity;Agonist;Alpha Cell;Area;attenuation;Beta Cell;Biology;Blood Pressure;Body Temperature;Body Weight;Bombesin;Bombesin Receptor;bombesin receptor subtype 3;Brain;Brain Stem;Cannabinoids;Cardiovascular Diseases;Cell Line;Cell Nucleus;Cholelithiasis;combinatorial;comorbidity;complement pathway;Cre driver;Degenerative polyarthritis;Drug Kinetics;Dyslipidemias;Eating;Effectiveness;Fasting;Feedback;G-Protein-Coupled Receptors;Genetic;Genetic Transcription;Glucose;Goals;Health;Heart Rate;Homeostasis;Hypertension;Hypothalamic structure;improved;insulin secretion;interest;Islets of Langerhans;Knock-out;Leptin;Life Expectancy;Ligands;Malignant Neoplasms;member;metabolic rate;Midbrain structure;mouse genetics;Mus;Names;Neurons;neuropeptide Y;Non-Insulin-Dependent Diabetes Mellitus;Obesity;obesity treatment;Oral;paraventricular nucleus;Pathway interactions;Pharmacology;Physiology;Population;Preoptic Areas;recombinase;reduced food intake;Regulation;Research;Rest;Risk;Rodent;Role;Signal Pathway;Sympathetic Nervous System

PROJECT_TITLE: Physiology and Pharmacology of BRS3 (Bombesin Receptor Subtype-3)


NIH_SPENDING_CATS: American Indian or Alaska Native;Childhood Obesity;Diabetes;Genetics;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Nutrition;Obesity;Pediatric;Racial and Ethnic Minority Health Research

PROJECT_TERMS: Adipocytes;Adipose tissue;Adult;Affect;Alleles;American Indians;Amish;Animals;Architecture;Arizona;Asian ancestry;Body mass index;Butyrates;Candidate Disease Gene;Cell Size;Cells;Child;Childhood;clinical phenotype;Code;Codon Nucleotides;Complex;D-Amino Acid Dehydrogenase;Data;detection assay;Development;diabetes mellitus genetics;diabetes risk;Diabetic Nephropathy;Disease;disorder risk;DNA;Dopamine;Dyslipidemias;East Asian;Elements;energy balance;Energy Metabolism;enzyme activity;Enzymes;Ethnic Population;European;European ancestry;Exclusion;Exhibits;exome;exome sequencing;Familial partial lipodystrophy;Fatty Acids;Fatty Liver;FOXO1A gene;Frequencies;Gene Frequency;Genes;Genetic Transcription;genome sequencing;genome wide association study;genome-wide;Genomics;Genotype;Glucose;Glycerol;Heritability;Hour;Human;Hydrolysis;IGFBP4 gene;Impairment;In Vitro;Indigenous;Indigenous American;indigenous community;Individual;Infusion procedures;insertion/deletion mutation;Insulin;Insulin Resistance;insulin sensitivity;Insulin-Like Growth Factor I;Insulin-Like Growth-Factor-Binding Proteins;Isoproterenol;Knockout Mice;Large-Scale Sequencing;Link;Lipase;lipid biosynthesis;lipid metabolism;Lipids;Lipolysis;Longitudinal Studies;loss of function;loss of function mutation;Measures;Mediating;Methods;Minor;Modeling;Morbid Obesity;Mus;new therapeutic target;Non-Insulin-Dependent Diabetes Mellitus;Nonesterified Fatty Acids;Nonsense Codon;novel;NTRK2 gene;Nuclear;Obesity;OGTT;oxidation;Pathogenicity;Pathway interactions;Persons;Phase;Phenotype;PI3K/AKT;Plasma;Population;Prediabetes syndrome;Predisposition;Privatization;protein degradation;Protein Isoforms;Proteins;rare variant;Reporter;Reporting;Research Personnel;Risk;Role;Sampling;Serine;Siblings;Signal Transduction;Single Nucleotide Polymorphism;Sleep;Somatomedins;sterol esterase;Techniques;Testing;Therapeutic;Threonine;trait;Triglycerides;United States;Variant;whole genome

PROJECT_TITLE: Whole Genome and Whole Exome Sequencing to Identify Genes for Type 2 Diabetes and Obesity


NIH_SPENDING_CATS: Nutrition;Obesity

PROJECT_TERMS: Anti-Obesity Agents;Biological Assay;Biology;Body Temperature;Bupropion;cost effective;Diabetes Mellitus;drug development;Eating;Energy Metabolism;Goals;Homeostasis;Human;human model;Knowledge;liraglutide;Medical;metabolic rate;Metabolism;mouse model;Mus;Naltrexone;Obesity;obesity treatment;orlistat;Persons;Pharmaceutical Preparations;Pharmacodynamics;pharmacologic;Pharmacological Treatment;Pharmacotherapy;Phentermine;Physiologic Thermoregulation;Physiology;Temperature;Therapeutic;topiramate;Translating;United States;virtual;Work

PROJECT_TITLE: Pharmacologic approaches to the treatment of obesity


PROJECT_TERMS: Adult;Agonist;awake;Basal metabolic rate;Biology;Body Temperature;Body Weight;Body Weight decreased;Brain;Brown Fat;Cardiac;circadian;clinical development;cold stress;cost;Darkness;diet-induced obesity;Disease;Dissection;Diurnal Rhythm;drug efficacy;drug testing;Energy Intake;Energy Metabolism;Evaluation;Exhibits;Expenditure;experimental study;fibroblast growth factor 21;Food;GDF15 gene;glucagon-like peptide 1;Home;Homeostasis;House mice;Human;human disease;human model;inter-individual variation;Knockout Mice;Light;Link;Mammals;Measurement;Measures;Melanocortin 4 Receptor;Metabolic;metabolic rate;Modeling;Mus;Muscle;Obesity;Peptide YY;Pharmaceutical Preparations;Phase;Photoperiod;Physical activity;Physiological;Physiology;prevent;Rest;Sampling;Shapes;Sleep;Temperature;Thermogenesis;Time;total energy expenditure;virtual;Weight-Loss Drugs;Work

PROJECT_TITLE: What can body temperature tell us about energy homeostasis?


NIH_SPENDING_CATS: Neurosciences;Nutrition;Obesity

PROJECT_TERMS: Acute;Adrenergic Agonists;Adult;Biology;Body Temperature;Body Weight;Brown Fat;comorbidity;Dinitrophenols;energy balance;Energy Metabolism;Ensure;experimental study;Genes;Goals;Histamine;Homeostasis;House mice;Human;Insulin Resistance;interest;Knockout Mice;Mammals;metabolic rate;Modeling;Mus;natural hypothermia;Neurons;Obese Mice;Obesity;Preoptic Areas;Protons;receptor;Role;Temperature;Tissues

PROJECT_TITLE: Role of brown adipose tissue (BAT) in energy balance


PI_NAMEs: CHOW, CARSON  (contact)

PROJECT_TERMS: Binding;biochemical model;Biological Assay;Cells;cellular imaging;cofactor;Collaborations;Computer software;Data;Data Set;design;Dose;experimental study;Gene Expression;gene product;Genes;Genetic Transcription;Goals;Image;Kinetics;Location;Malignant Neoplasms;Mediating;Messenger RNA;Modeling;molecular imaging;MYC gene;next generation;novel;open source;Pharmaceutical Preparations;Positioning Attribute;predictive modeling;Process;Reaction;Repression;Resolution;response;RNA;Site;Spliced Genes;Steroid Receptors;Steroids;Theoretical model;theories;Time;whole genome;Writing

PROJECT_TITLE: Modeling gene transcription


NIH_SPENDING_CATS: American Indian or Alaska Native;Clinical Research;Diabetes;Genetics;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Physical Activity;Prevention;Racial and Ethnic Minority Health Research

PI_NAMEs: HANSON, ROBERT  (contact)

PROJECT_TERMS: Arizona;Biolectric Impedance;Body Composition;Calories;Clinical Research;Collaborations;Community Health;Cross-Sectional Studies;Data;Diabetes Mellitus;Diet;Disease;DNA Methylation;doubly-labeled water;Eligibility Determination;Energy Metabolism;Enrollment;Environment;environmental change;epidemiology study;epigenetic marker;Ethnography;experience;Fatty acid glycerol esters;Fiber;Frequencies;Genetic;Genetic Polymorphism;genetic variant;Glycosylated hemoglobin A;Goals;health belief;Height;High Prevalence;Immune System Diseases;Indirect Calorimetry;Individual;Insulin-Dependent Diabetes Mellitus;Life Style;Low Prevalence;Measurement;Measures;men;Methods;Mexican;Mexico;Modernization;National Institute of Diabetes and Digestive and Kidney Diseases;Non-Insulin-Dependent Diabetes Mellitus;Obesity;obesity risk;oral glucose tolerance;Oral health;Other Genetics;Physical activity;Pima Indian;Population;Prevalence;Research Personnel;Rest;Societies;Surveys;Technology;total energy expenditure;United States;Universities;Variant;ventilation;waist circumference;Weight;Woman

PROJECT_TITLE: Diabetes and Obesity in Mexican Pima Indians


NIH_SPENDING_CATS: American Indian or Alaska Native;Clinical Research;Diabetes;Genetics;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Nutrition;Obesity;Prevention;Racial and Ethnic Minority Health Research

PROJECT_TERMS: American Indians;Blood Glucose;Blood specimen;Chronic;Code;Collaborations;Complications of Diabetes Mellitus;Data;Development;Diabetes Mellitus;diabetes risk;diabetic;disorder risk;DNA Methylation;Environmental Risk Factor;Epidemiology;epidemiology study;Epigenetic Process;Family;follow-up;Frequencies;Gene Expression;Gene Expression Profile;Genes;Genetic;genetic epidemiology;Genetic Polymorphism;Genetic Transcription;genome-wide;genome-wide analysis;Genomic DNA;Genotype;Goals;Heritability;high risk;high risk population;histone modification;identity by descent;Individual;Insulin Resistance;Kidney Diseases;Longitudinal Studies;Measures;Metabolic Diseases;Metabolism;metabolomics;Modality;Molecular;Molecular Profiling;Muscle;Natural Selections;non-diabetic;Non-Insulin-Dependent Diabetes Mellitus;Obesity;Parents;Pathway interactions;Pattern;peripheral blood;Peripheral Nervous System Diseases;Phenotype;Process;protein expression;Proteins;recruit;Research Personnel;Retinal Diseases;Risk;Risk Factors;RNA;Sampling;Skeletal Muscle;Techniques;Texas;Transcript;transcriptomics;Universities;Variant

PROJECT_TITLE: Molecular Profiling of Diabetes and its Complications


NIH_SPENDING_CATS: Diabetes;Genetics

PI_NAMEs: RANE, SUSHIL  (contact)

PROJECT_TERMS: Activins;Adult;Beta Cell;Biological Assay;Biology;Cell Physiology;Cells;clinically relevant;Complex;Diabetes Mellitus;diabetes pathogenesis;Dominant-Negative Mutation;established cell line;Exhibits;Functional disorder;Gene Expression;gene repression;Genes;Genetic Transcription;Glucose;glucose tolerance;Human;Hyperinsulinism;Hypoglycemia;improved;in vivo;Insulin;Insulin Receptor;insulin regulation;insulin secretion;islet;Islets of Langerhans;Knowledge;Morphogenesis;mouse model;Mus;Non-Insulin-Dependent Diabetes Mellitus;nonhuman primate;Pancreas;pancreas development;Pancreatic Diseases;Pathway Analysis;Pathway interactions;Play;promoter;Regulation;Repression;Role;Sampling;Signal Pathway;Signal Transduction;Small Interfering RNA;Transforming Growth Factor beta

PROJECT_TITLE: Transforming Growth Factor Beta Superfamily Signaling in Pancreas Biology


NIH_SPENDING_CATS: Aging;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Diabetes;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Nutrition;Obesity;Physical Activity;Prevention

PROJECT_TERMS: adjudication;Adult;Age Years;aged;Aging;American Indian Population;Angiography;Anti-Hypertensive Agents;Blinded;Blood Vessels;Body mass index;Body Weight decreased;Cardiovascular Diseases;cardiovascular risk factor;Cardiovascular system;Cause of Death;Cells;Cessation of life;Clinic;Clinical;clinical center;Clinical Research;Clinical Trials;Compensation;Complex;Complications of Diabetes Mellitus;Coronary;Coronary heart disease;Data Collection;design;Development;Diabetes Mellitus;diabetes prevention program;Disease remission;Education;Electrocardiogram;Energy Intake;Enrollment;Environment;epidemiology study;Event;Expectancy;Eye;follow-up;Follow-Up Studies;frailty;gene environment interaction;gene interaction;Genes;genetic architecture;genome wide association study;Genotype;Glucose;Goals;group intervention;hazard;Health;Health Care Costs;heart disorder diagnosis;Heart failure;Heterogeneity;high risk;Hospitalization;Incidence;Insulin;Insulin Resistance;insulin secretion;interest;Intervention;intervention effect;intervention program;Intervention Studies;Kidney;life span;Life Style;Life Style Modification;lifestyle intervention;Long-Term Effects;Longterm Follow-up;macrovascular disease;Malignant Neoplasms;Measures;Mediating;Metformin;Microvascular Dysfunction;Modeling;mortality;mortality risk;Multi-Institutional Clinical Trial;Myocardial Infarction;Native Americans;Non-Insulin-Dependent Diabetes Mellitus;Obesity;Outcome;Outcome Study;Overweight;Participant;Pattern;Peripheral;Persons;Phase;Physical activity;Placebos;prevent;Prevention;primary outcome;Primary Prevention;programs;Quality of life;Randomized;randomized, clinical trials;Recording of previous events;recruit;Reporting;Research;response;revascularization;Risk;Risk Factors;Role;secondary analysis;secondary outcome;Stroke;Subgroup;success;Techniques;tertiary prevention;Testing;therapy design;Time;trait;Treadmill Tests;treatment effect;treatment program;Unstable angina;volunteer;Work

PROJECT_TITLE: Primary and Tertiary Prevention of type 2 diabetes


NIH_SPENDING_CATS: Aging;Atherosclerosis;Bioengineering;Biomedical Imaging;Cardiovascular;Clinical Research;Congenital Structural Anomalies;Digestive Diseases;Heart Disease;Heart Disease - Coronary Heart Disease;Infectious Diseases;Liver Disease;Nutrition;Pediatric;Prevention

PI_NAMEs: GHARIB, AHMED  (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Affect;Anti-Inflammatory Agents;Arterial Fatty Streak;Atherosclerosis;Blood Vessels;Body mass index;burden of illness;Cardiac;Choline;Controlled Environment;Coronary;Coronary Arteriosclerosis;Coronary artery;Coronary Vessel Anomalies;Coronary Vessels;Cushing Syndrome;detection method;Development;Disease;Early Diagnosis;experience;Fatty acid glycerol esters;glucose metabolism;Glycogen;Heart;HIV;HIV/AIDS;Human;Image;imaging modality;improved;Ionizing radiation;lipid metabolism;Lipids;Liver;Liver Fibrosis;Liver Glycogen;magnetic field;Magnetic Resonance Imaging;Magnetic Resonance Spectroscopy;Measurement;Measures;Metabolic;Methods;millisecond;Monitor;Morphology;Motion;Muscle;Noise;non-invasive imaging;Pancreas;Patients;Phase;Protons;Publications;Recovery;Resolution;response;Signal Transduction;Spectrum Analysis;Subcutaneous Tissue;Techniques;Thick;Time;Visualization

PROJECT_TITLE: Advanced Non Invasive Vascular Imaging Methods


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Diabetes;Digestive Diseases;Genetics;Human Genome;Neurosciences;Pancreatic Cancer;Rare Diseases

PROJECT_TERMS: Adrenal Gland Neoplasms;Affect;Angiofibroma;Anterior Pituitary Gland;Apoptosis;Apoptotic;ATRX gene;autosome;Beta Cell;Binding Proteins;Biological;Biological Markers;Blood;Carcinoid Tumor;CBLB gene;Cell Cycle Progression;Cell Differentiation process;Cell Line;Cell Nucleus;Cell Proliferation;cell transformation;cell type;Cells;Central Nervous System Neoplasms;ChIP-seq;clinically relevant;Collagen nevus of skin;Data;DAXX gene;Defect;design;Diabetes Mellitus;Disease of parathyroid glands;effective therapy;Embryo;Embryonic Development;embryonic stem cell;Endocrine;Endocrine Gland Neoplasms;Ependymoma;Epigenetic Process;Esophageal Neoplasms;Event;Face;Gene Expression;Gene Expression Profile;Gene Mutation;Genes;Genetic;Germ-Line Mutation;glycogen synthase kinase 3 beta;glycogen synthase kinase 3 beta inhibitor;Goals;Hematopoietic stem cells;Heterozygote;Human;Impairment;Inherited;inhibitor;inhibitor therapy;insulinoma;interest;Intestinal Neuroendocrine Neoplasm;Investigation;Islet Cell Tumor;Islets of Langerhans;Leiomyoma;Life;Link;Lipoma;Lithium Chloride;Mediating;Menin;meningioma;Molecular;Molecular Profiling;morphogens;mortality;mouse model;Multiple Endocrine Neoplasia Type 1;Mus;mutant;Mutation;Nature;neonatal diabetes mellitus;Neuroendocrine Cell;neuroendocrine differentiation;Neuroendocrine Tumors;Nuclear RNA;Oncogenic;Pancreas;pancreatic neoplasm;Parathyroid Adenoma;Parathyroid gland;Parathyroid Neoplasms;Pathogenesis;Pathway interactions;Patients;Phosphorylation;Phosphotransferases;Polyamines;posttranscriptional;Primitive foregut structure;protein expression;Protein Isoforms;Proteins;proteomic signature;Proto-Oncogene Protein c-met;rare variant;receptor;Recurrence;Regulation;RNA-Binding Proteins;Role;skin lesion;Small Intestines;Smooth Muscle Tumor;Specific qualifier value;Specificity;Stomach;Syndrome;synthetic peptide;telomere;Therapeutic;therapeutic target;Thymoma;Thymus Carcinoid Tumor;Thymus Gland;Thymus Neoplasms;Tissue Differentiation;Tissues;transcription factor;transcriptome sequencing;transcriptomics;tumor;tumor progression;tumorigenesis;Up-Regulation;Uterine Fibroids

PROJECT_TITLE: Role of tissue differentiation factors in endocrine tumorigenesis


NIH_SPENDING_CATS: Neurosciences

PI_NAMEs: KRASHES, MICHAEL J. (contact)

PROJECT_TERMS: Acute;Agonist;Amygdaloid structure;Anatomy;Animals;Behavioral;Binding;Body Weight;cell type;Chronic;Complex;Data;Dependovirus;design;designer receptors exclusively activated by designer drugs;Eating;Enterobacteria phage P1 Cre recombinase;experimental study;falls;feeding;Feeding behaviors;Feeling;Future;G-Protein-Coupled Receptors;Grant;Hormones;Hypothalamic structure;Immunohistochemistry;in vivo;Injections;Ion Channel;Ion Pumps;Knock-out;Knockout Mice;Label;Laboratories;Lateral;Ligands;Light;LoxP-flanked allele;Maps;Medial;Mediating;Melanocortin 4 Receptor;melanocyte;midbrain central gray substance;Modality;Mus;neural;neural circuit;neural network;neuronal cell body;Neurons;Nose;Nucleus Accumbens;Nucleus solitarius;Obesity;optical imaging;optogenetics;Output;parabrachial nucleus;Pharmacogenetics;pharmacologic;Physiological;Population;preference;Pro-Opiomelanocortin;promoter;Protocols documentation;receptor;Receptor Gene;Regulation;Reporter;restoration;Role;Satiation;Self Stimulation;Signal Transduction;Site;Structure of nucleus infundibularis hypothalami;Structure of terminal stria nuclei of preoptic region;Synaptophysin;Thalamic structure;Tracer;Transgenic Organisms;Virus

PROJECT_TITLE: Probing neural circuits underlying satiety


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Eating Disorders;Mental Health;Neurosciences;Nutrition;Obesity

PROJECT_TERMS: Acute;Animals;Behavior;behavior change;Bilateral;Binge Eating;Biological Assay;Body Weight;Body Weight decreased;Chronic;comparison control;Consumption;designer receptors exclusively activated by designer drugs;Eating;Eating Behavior;Ensure;Equipment;experimental study;Fatty acid glycerol esters;feeding;Feeding behaviors;Food;Food Access;food consumption;Future;Hour;Hunger;Hyperphagia;Hypothalamic structure;in vivo;Measures;Mediating;Monitor;Motor Activity;Mus;neural;Neurons;Nose;Obese Mice;optogenetics;Oxygen Consumption;Pharmacogenetics;Population;Property;Protocols documentation;Psychological reinforcement;Reagent;reduced food intake;Reporting;Role;Satiation;Signal Pathway;Thinness;Time;tool;Transgenic Organisms;Viral;Weight Gain;willingness;Work

PROJECT_TITLE: Investigating addictive/compulsive feeding behavior


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences;Nutrition

PROJECT_TERMS: Acute;Agonist;antagonist;Antibodies;Area;Attention;Attenuated;Behavior;Biological Assay;Body Weight;cell type;conditioned place preference;design;Diffuse;Dorsal;Drosophila genus;Eating;Equipment;experimental study;feeding;Feeding behaviors;Food;Frequencies;Hippocampus;Homeostasis;Hypothalamic structure;Immunohistochemistry;In Vitro;in vivo;Injections;Length;Leptin;leptin receptor;Love;Measurement;Melanocortin 4 Receptor;Memory;memory process;Mus;neural circuit;Neurons;Obsession;optogenetics;Output;Paper;Pattern;pharmacologic;Positioning Attribute;promoter;Protocols documentation;Publishing;Rabies virus;receptor;receptor expression;reduced food intake;Retrieval;Rodent;Role;Satiation;Signal Transduction;Slice;STAT3 gene;Synapsins;Testing;tool;Viral;Virus

PROJECT_TITLE: Unraveling hippocampal networks related to food memories


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences;Nutrition;Obesity

PROJECT_TITLE: Investigating the interaction of motivational systems


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Coronaviruses;Emerging Infectious Diseases;Genetics;Infectious Diseases

PI_NAMEs: PERIWAL, VIPUL  (contact)

PROJECT_TERMS: 2019-nCoV;Accounting;Amino Acid Sequence;Amino Acids;antiretroviral therapy;Biological;Capsid;Chronology;combinatorial;Complex;computing resources;Coupling;Data;Data Collection;Data Set;Data Storage and Retrieval;Development;Disease Outbreaks;Drug resistance;Entropy;env Glycoproteins;Equilibrium;Evolution;expectation;Face;Family;fitness;Future;Genetic Anticipation;Genetic Epistasis;genome-wide analysis;Growth;heuristics;HIV;HIV-1 drug resistance;Homologous Protein;Immune system;improved;Individual;Infection;Information Sciences;insight;Integrase;large datasets;large scale data;Lead;lens;macromolecule;Methodology;Methods;Modeling;Mutate;Mutation;Names;neutralizing antibody;novel;pathogen;Pathway interactions;Pattern;Peptide Hydrolases;Persons;Pharmaceutical Preparations;Pharmacotherapy;Phylogenetic Analysis;Population;Positioning Attribute;pressure;Probability;protein function;protein structure;protein structure prediction;Proteins;Publications;Regimen;resistance mutation;Rest;Retrotransposon;RNA-Directed DNA Polymerase;Role;Route;SARS-CoV-2 genome;Science;Sequence Alignment;Sequence Analysis;success;System;Techniques;Technology;Therapeutic;therapeutic target;tool;Treatment Protocols;Viral;viral fitness;Viral Genome;Viral Proteins;Virus;Work

PROJECT_TITLE: Pattern Identification in Sequence Activity Data


NIH_SPENDING_CATS: Bioengineering

PI_NAMEs: BEST, ROBERT  (contact)

PROJECT_TERMS: 2019-nCoV;Accounting;Address;Affinity;Amyloid;Amyloid Fibrils;Area;Cell Nucleus;Cells;Charge;Collaborations;Collagen;Collagen Fiber;Complex;Coupling;Cytoplasmic Granules;Data;Data Set;Dependence;design;Development;Disease;doctoral student;Evolution;Exclusion;experimental study;Extracellular Matrix;Fluorescence Resonance Energy Transfer;Friction;Goals;Grain;improved;interest;Investigation;Ions;Length;Liquid substance;Measurement;Measures;member;Membrane;Membrane Proteins;Methodology;Methods;Modeling;models and simulation;Molecular;Molecular Conformation;molecular dynamics;Molecular Structure;Neutrons;non-Native;novel;Nuclear Proteins;Nucleic Acids;Organelles;Osmotic Pressure;Pathway interactions;Peptide Hydrolases;Peptides;Phase;Physical condensation;Procedures;Property;protein aggregation;protein complex;Protein Dynamics;protein folding;protein function;protein misfolding;Proteins;protonation;Regulation;Resolution;Roentgen Rays;Running;Scanning;Set protein;Signal Transduction;simulation;single-molecule FRET;Site;Sodium Chloride;Structure;System;Temperature;theories;Universities;Work

PROJECT_TITLE: Understanding protein folding, evolution and function via molecular simulation


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Diabetes;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Liver Disease;Nutrition;Obesity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

PI_NAMEs: CHUNG, STEPHANIE THERESE (contact)

PROJECT_TERMS: Adipose tissue;African;African American;African American population;African American Women;African ancestry;African Women;Age;Biological;black women;Blood Glucose;Body fat;Body mass index;cardiometabolic risk;Circulation;Clinical Endocrinology;Complex;Contractor;design;Detection;detection sensitivity;Development;Diabetes Mellitus;diabetes risk;Diet;Dietary Assessment;Disease;Eligibility Determination;Employee;Endocrinology;Energy Metabolism;epidemiology study;ethnic difference;Ethnic Origin;Evaluation;Fasting;fasting glucose;Fatty acid glycerol esters;fatty acid metabolism;Fatty Acids;genetic analysis;genetic variant;Gluconeogenesis;Glucose;glucose metabolism;glucose production;glycogenolysis;health care availability;Heart Diseases;Hepatic;Hyperglycemia;insight;Insulin;Insulin Resistance;Journals;Life Style;lipid metabolism;lipidomics;Liver;Low Prevalence;low socioeconomic status;Manuscripts;Measures;Metabolism;metabolomics;Non-Insulin-Dependent Diabetes Mellitus;novel;Nutritional;Pathway interactions;Peer Review;Physical activity;Physiological;Population;precision nutrition;Prediabetes syndrome;Premenopause;Preparation;Protocols documentation;Psychosocial Factor;Publishing;Race;racial difference;Research;Resources;Risk Factors;screening;Screening procedure;secondary analysis;Testing;Tissues;Triglycerides;Variant;White Women;Woman;Women's study

PROJECT_TITLE: Nested Study: Identifying Risk for Diabetes and Heart Disease in Women: A Study of African-American, African and White Federal Employees and Contractors


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Neurosciences;Nutrition;Obesity

PI_NAMEs: HALL, KEVIN  (contact)

PROJECT_TERMS: Adult;Affect;antagonist;Body fat;Body mass index;Brain;Brain region;Clinical Research;Complex;Corpus striatum structure;Data;dietary;Dopamine D2 Receptor;Eating;Eating Behavior;Fasting;Food;Habits;high body mass index;Hour;Human;Individual;Mathematics;Measures;Methodology;Nature;neural;neural circuit;neural correlate;neuroimaging;Neurosciences;Obesity;Perception;Physiological;Positron-Emission Tomography;radioligand;receptor binding;Reporting;Research;research study;response;reward processing;Signal Transduction;Standardization;Stimulus;Techniques;Time

PROJECT_TITLE: Neuroscience of human food perception and eating behavior


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

PI_NAMEs: HAASE, ASTRID  (contact)

PROJECT_TERMS: Adult;Age;age-related disease;Animals;Autoimmune Diseases;Biochemistry;Biogenesis;Biology;Biotechnology;Cancer Biology;Cells;chromatin modification;Complex;Conflict (Psychology);Development;Discrimination;Disease;Drosophila genus;Ensure;Epigenetic Process;Event;experimental study;Fertility;fly;Foundations;Gene Expression;Genes;Genetic;genetic element;genetic makeup;Genetic Transcription;Genome;genome integrity;Genome Stability;genomic locus;Genomics;Germ Cells;Germ Lines;Goals;Human;Immune system;innovation;Insecta;insight;Length;Maintenance;Mediating;meetings;Molecular;Mus;Mutagenesis;next generation sequencing;novel;Parasites;Pathway interactions;piRNA;Play;Positioning Attribute;posttranscriptional;preference;Proteins;Repression;restraint;RNA;RNA Decay;RNA Interference;Role;Secure;Small RNA;Somatic Cell;Specificity;Surveys;System;targeted treatment;Time;Toxic effect;Transcript;Untranslated RNA;Uridine;Virus;Yeasts

PROJECT_TITLE: PIWI proteins and PIWI-interacting small RNAs guard the genomic integrity of germ cells


PI_NAMEs: CYPESS, AARON  (contact)

PROJECT_TERMS: Acute;Adipocytes;Adipose tissue;Adult;Anatomy;Atlases;Biological Markers;Biological Models;Biopsy;Brown Fat;Cell Physiology;Cell surface;Cells;Chad;Collaborations;Communities;COVID-19;COVID-19 susceptibility;Data;Development;Energy Metabolism;Fatty acid glycerol esters;FGF21 gene;fibroblast growth factor 21;Gene Expression;Gene Expression Profiling;Gene Targeting;Genetic;genetic signature;Genetic Transcription;Growth;Heterogeneity;HIV;Human;Human Cell Line;immunodeficiency;improved;In Vitro;in vitro Model;in vivo;insulin sensitivity;Intervention;IRF4 gene;lipid biosynthesis;Lipodystrophy;Maps;medical schools;Metabolic;Metabolism;MicroRNAs;Molecular;Neck;novel;Nude Mice;Oncology;Organ;Patients;PET/CT scan;Physiological;Physiology;Plasma;Positron-Emission Tomography;Process;programs;Reporting;Risk;Rodent;Role;stem cell model;Structure;Testing;Tissues;Transplantation;ultrasound;United States National Institutes of Health;Wood material

PROJECT_TITLE: The Molecular, Cellular, and Genetic characterization of Human Adipose Tissue and its Role in Metabolism


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Neurodegenerative

PI_NAMEs: CHUNG, HOI SUNG  (contact)

PROJECT_TERMS: abeta accumulation;aggregation pathway;Alexa594;Alzheimer's Disease;American;Amyloid Fibrils;Binding;Binding Proteins;cell growth regulation;Chemicals;Collaborations;Color;Complex;Data;Data Analyses;Development;Diffusion;Disease;Event;experimental analysis;experimental study;fluorescence imaging;fluorescence lifetime imaging;Fluorescence Resonance Energy Transfer;fluorophore;Genetic Polymorphism;Genetic Transcription;Goals;Heterogeneity;Image Analysis;imaging modality;Individual;Journals;Label;Malignant Neoplasms;Methods;Microscopic;Molecular;Molecular Conformation;Monitor;Parkinson Disease;Pathology;Pathway interactions;Pattern;Peptides;Phase;Physical Chemistry;Process;protein aggregation;protein folding;Protein Isoforms;protein misfolding;Proteins;Publications;Publishing;Resolution;Role;Signal Transduction;single molecule;single-molecule FRET;Societies;Statistical Data Interpretation;stoichiometry;Structure;Time;tool;Variant;Work

PROJECT_TITLE: Single molecule studies of protein binding and aggregation


NIH_SPENDING_CATS: American Indian or Alaska Native;Biotechnology;Childhood Obesity;Conditions Affecting the Embryonic and Fetal Periods;Diabetes;Genetics;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Maternal Health;Nutrition;Obesity;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Racial and Ethnic Minority Health Research;Women's Health Research

PI_NAMEs: BAIER, LESLIE J (contact)

PROJECT_TERMS: Affect;Age;American Indians;bead chip;Beta Cell;Biological;Blood;Blood specimen;Cardiovascular Diseases;Cell Physiology;Cell Proliferation;Child;cohort;CYP1A1 gene;Cytosine;Data Set;Development;Diabetes Mellitus;diabetes risk;diabetic;Disease;DNA;DNA Methylation;Embryonic Development;Environment;Epigenetic Process;epigenetic regulation;epigenome-wide association studies;Ethnic Population;Exposure to;Fatty acid glycerol esters;Fetal Development;Fetal health;Future;Gene Expression Regulation;Genes;Genetic Enhancer Element;genome-wide;genome-wide analysis;Genomics;gestational weight gain;glucose tolerance;Guanine;hazard;Health;high risk;Hypermethylation;Impairment;in utero;Individual;Infant;Inflammation;inorganic phosphate;Insulin;insulin secretion;Intercistronic Region;Leukocytes;Life;logarithm;Longitudinal Studies;Maps;maternal diabetes;Maternal Health;maternal obesity;Measures;Metabolic;Metabolic Diseases;Methylation;methylation pattern;Modification;Mothers;Native Americans;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;offspring;Outcome;Pathway interactions;peripheral blood;Pima Indian;Placenta;Population;Pregnancy;Pregnancy Complications;Reporting;Risk;Role;RRAS2 gene;Sampling;Siblings;Signal Transduction;Site;Source;STC1 gene;Testing;text searching;Time;Tissues;transmission process;Weight;Weight Gain

PROJECT_TITLE: Epigenetic modifications associated with intrauterine exposure to maternal type 2 diabetes.


NIH_SPENDING_CATS: Diabetes;Genetics;Nutrition;Obesity

PROJECT_TERMS: Ablation;Acids;Address;adipocyte differentiation;Adipocytes;Adipose tissue;Adrenergic Agents;Adrenergic Agonists;Adrenergic Receptor;Agonist;Anabolism;Anatomy;Arachidonate 12-Lipoxygenase;Bile Acids;Biochemistry;Bioinformatics;Blood Pressure;Body fat;Body measure procedure;Boston;Brown Fat;C57BL/6 Mouse;Cardiovascular system;Cell Line;Cells;Clinical;Clinical Trials;Collaborations;Collection;Corticotropin;COVID-19;Cyclic AMP;Data;Diabetes Mellitus;Diet;diet-induced obesity;Dose;Ephedrine;Experimental Models;Failure;Fatty acid glycerol esters;fatty acid metabolism;Gene Expression;Gene Expression Profile;Gene Expression Profiling;Gene Targeting;Generations;Genes;genetic signature;glucose metabolism;glucose tolerance;glucose uptake;Health;Heart Rate;Heterogeneity;High Fat Diet;Human;Human Cell Line;Human Cloning;immunodeficiency;impaired glucose tolerance;Impairment;improved;In Vitro;in vitro Model;in vivo;Inflammation;inflammatory marker;Insulin;Insulin Resistance;insulin signaling;Leukocytes;Ligand Binding;Ligands;lipidomics;Lipolysis;Maps;Mass Spectrum Analysis;Mediating;medical schools;member;Messenger RNA;Metabolic;Metabolic Diseases;Mitochondria;Modeling;mRNA Expression;Mus;Neck;Norepinephrine;novel;Nude Mice;obese patients;Obesity;Oxygen Consumption;Patients;pharmacologic;Pharmacological Treatment;Phosphorylation;Physiology;Population;Postdoctoral Fellow;Process;receptor expression;Respiration;response;Risk;Rodent;Role;Sampling;Signal Pathway;Skeletal Muscle;Sympathomimetics;Testing;Thermogenesis;Time;Tissue Differentiation;Tissues;TNF gene;Transplantation

PROJECT_TITLE: Mechanisms Underlying Adipose Tissue Thermogenesis


NIH_SPENDING_CATS: Biomedical Imaging;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Nutrition;Obesity

PROJECT_TERMS: Acute;adiponectin;Adipose tissue;Adrenergic Agonists;Adrenergic Receptor;Adult;Adverse effects;Advisory Committees;Anti-diabetic Drugs;Anti-Inflammatory Agents;Antioxidants;Atlases;Axilla;Basal metabolic rate;bile acid metabolism;Bile Acids;Binding;Biological Markers;Bladder;Blood;Body Composition;Body mass index;Body Weight;Brown Fat;Cardiovascular system;Catecholamines;Cervical;Chronic;Clinical;Clinical Trials;clinically relevant;Collaborations;COVID-19 treatment;Development;Diabetes Mellitus;Diastolic blood pressure;Dose;Effectiveness;effectiveness study;Energy Metabolism;experience;Fatty acid glycerol esters;Fatty Acids;FDA approved;fluorodeoxyglucose;fluorodeoxyglucose positron emission tomography;Future;Gallbladder;Glucose;High Density Lipoproteins;Hormones;Hour;Human;improved;Individual;Inflammation;Insulin;insulin secretion;insulin sensitivity;interest;intravenous glucose tolerance test;Investigation;Label;Lipolysis;Lipoproteins;male;Measures;Mediastinal;meetings;men;Metabolic;Metabolic Diseases;Metabolism;metabolomics;Methods;microbiome;Obesity;Oral;Overactive Bladder;Paper;Patients;Pharmaceutical Preparations;pharmacologic;Phase;Physiological;Physiology;Pilot Projects;Placebos;Plasma;Polycystic Ovary Syndrome;Positron-Emission Tomography;primary endpoint;Publishing;Regional Anatomy;Relaxation;Reporting;Reproductive Health;Resistance;Resolution;response;Risk;Rodent;Series;Supraclavicular;Thermogenesis;Thinness;Thioctic Acid;Tissues;uptake;Woman;X-Ray Computed Tomography;young man

PROJECT_TITLE: Physiological Responses to Activation of Human Brown Adipose Tissue


NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Clinical Research;Hypertension;Rare Diseases

PI_NAMEs: NIEMAN, LYNNETTE  (contact)

PROJECT_TERMS: Admission activity;Adrenal Gland Hyperfunction;Adrenal Glands;Adrenal Mass;Adrenalectomy;Adrenergic Receptor;Algorithms;Bilateral;Biochemical;Blood Pressure;Case Study;Catecholamines;Corticotropin;Corticotropin-Releasing Hormone;Cushing Syndrome;Cushingoid habitus;Desmopressin;Dexamethasone;dexamethasone suppression test;Diagnosis;Diagnostic;diagnostic accuracy;diagnostic tool;Differential Diagnosis;Dose;Doxazosin;Etiology;Excision;Histopathology;Hydrocortisone;hypertensive;Immunohistochemistry;improved;Magnetic Resonance Imaging;Measures;Metanephrine;Morbidity - disease rate;Nodule;older women;Pathology;Patients;Performance;Periodicity;Peripheral;Petrosal Sinus Sampling;Pheochromocytoma;Physiological;Pituitary Gland;Pituitary Gland Adenoma;Pituitary-dependent Cushing's disease;Plasma;Positron-Emission Tomography;Postoperative Period;Predictive Value;Publishing;Quality of life;Radioisotopes;Recording of previous events;Recovery;Reporting;Research Personnel;response;Scanning;Serum;Specificity;Techniques;Test Result;Testing;tool;tumor;X-Ray Computed Tomography

PROJECT_TITLE: The differential diagnosis and treatment of Cushing's syndrome


NIH_SPENDING_CATS: Genetics;Infectious Diseases

PI_NAMEs: GUYDOSH, NICHOLAS  (contact)

PROJECT_TERMS: 5' Untranslated Regions;Address;Affect;Aging;Anticodon;Apoptosis;Apoptotic;Biochemistry;Biological Assay;Biological Process;C-terminal;Cell Nucleus;Cells;Code;Codon Nucleotides;Collaborations;Communicable Diseases;computerized tools;Data;Development;endonuclease;Ensure;environmental change;Event;Fluorescence;Fluorescence Microscopy;Frequencies;gamma-Glutamyl Hydrolase;Gene Expression;Gene Expression Regulation;Genes;Genetic Code;Genetic Transcription;Goals;Guanine + Cytosine Composition;Health;Human;Image;Infection;Innate Immune Response;interest;Isoleucine;Kinetics;Length;Malignant Neoplasms;Measures;Messenger RNA;Molecular;mRNA Decay;mRNA Transcript Degradation;mRNA Translation;new therapeutic target;nitrogen metabolism;Nonsense Codon;Nonsense-Mediated Decay;novel;Nutrient;Open Reading Frames;Oxidative Stress;Pancreatic ribonuclease;Pathway interactions;Phenotype;Phosphotransferases;Play;premature;prevent;Process;programs;Proline;promoter;Protein Array;Protein Isoforms;Proteins;Quality Control;recruit;Recycling;release factor;Reporter Genes;Research;Residual state;Respiratory syncytial virus;Respiratory Syncytial Virus Infections;response;Ribonucleases;Ribosomal Proteins;Ribosomal RNA;ribosome profiling;Ribosomes;RNA;RNA Degradation;Role;sensor;Signal Pathway;single molecule;Stress;Techniques;Terminator Codon;Testing;Time;Transcript;transcriptome;transcriptome sequencing;Transfection;Transfer RNA;Translating;Translation Initiation;Translation Process;translational genetics;Translational Regulation;Translations;Ubiquitin;Universities;Viral;viral RNA;Virus;Virus Diseases;Work;Yeasts

PROJECT_TITLE: Molecular mechanism of the ribosome and functions of translational regulation


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Racial and Ethnic Minority Health Research

PROJECT_TERMS: Address;Adolescent;Adult;Affect;African American;African American population;African ancestry;Age;aged;American;Anti-diabetic Drugs;Beta Cell;Cell Physiology;Cells;Child;Childhood;Combined Modality Therapy;Complication;Data;Data Analyses;design;Diabetes Mellitus;Diagnosis;Disease;Disparity;Drug Kinetics;Early treatment;eligible participant;Enrollment;Extrahepatic;Fatty Acids;follow-up;Gene Frequency;Genes;Genetic;Genetic Polymorphism;glucagon-like peptide 1;Gluconeogenesis;Glucose;glucose production;glucose tolerance;Glycosylated hemoglobin A;Goals;gut bacteria;health disparity;Hepatic;Hepatocyte;Heritability;high risk;Hormones;improved;improved outcome;Individual;Inpatients;Insulin;insulin secretion;insulin sensitivity;International;Intervention;Intervention Trial;Intestines;Light;Lipolysis;liraglutide;Liver;Manuscripts;Medical History;medication compliance;meetings;Metabolic;Metformin;Minor;minority children;Modeling;Monitor;Morbid Obesity;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutics;Oral;Outcome;Outpatients;Palmitates;Participant;Pathologic;Pathway interactions;Patients;Pharmaceutical Preparations;Physical Examination;Pilot Projects;Population;Precision Medicine Initiative;Prediabetes syndrome;Predictive Factor;Preparation;primary outcome;proctolin;Public Health;Publishing;Randomized;randomized trial;recruit;Regimen;Research;Research Design;Role;Running;screening;Single Nucleotide Polymorphism;Societies;solute;Testing;Therapeutic;therapeutic target;Time;treatment arm;Treatment Failure;Visit;Work;Youth

PROJECT_TITLE: Therapeutic targets in African-American youth with type 2 diabetes


NIH_SPENDING_CATS: HIV/AIDS;Infectious Diseases;Prevention

PI_NAMEs: APPELLA, DANIEL H (contact)

PROJECT_TERMS: Acetyl Coenzyme A;Acquired Immunodeficiency Syndrome;Biological Testing;chemical synthesis;Clinical;Collaborations;Death Rate;Drug Kinetics;Drug resistance;FDA approved;Female;Formulation;Generations;HIV;HIV Infections;HIV resistance;HIV-1;Human;in vivo;Injectable;Lead;Lysine;male;Metabolism;microbicide;Molecular;Peripheral Blood Mononuclear Cell;Pharmaceutical Preparations;Positioning Attribute;preclinical toxicity;prevent;Process;Prodrugs;Proteins;Resistance development;resistant strain;scaffold;Toxic effect;transacylation;Translating;transmission process;Vaccines;Variant;Viral;Viral Physiology;Virus;Virus Replication;Work

PROJECT_TITLE: Small Molecular Inactivators of HIV


PI_NAMEs: ZHANG, JINWEI  (contact)

PROJECT_TERMS: Adopted;Amino Acids;Amino Acyl-tRNA Synthetases;Aminoacylation;Antibiotics;Anticodon;Architecture;Bacteria;Bacterial Infections;Binding;Binding Proteins;Biogenesis;Biological Assay;Biological Models;biophysical analysis;Cell Physiology;Cellular Stress;Collaborations;Communication;Complex;dark matter;Data;Development;Dinucleoside Phosphates;Elbow;Elements;Enzymes;Family;flexibility;Fluorescence;Gene Expression;Gene Expression Regulation;Genes;Genetic Transcription;Genome;Gram-Positive Bacteria;Homeostasis;Human;human pathogen;Immunity;In Vitro;insight;Isomerism;Life;Location;Maintenance;MALAT1 gene;Malignant Neoplasms;Metabolic;Metabolic Diseases;Metabolism;mimicry;Modeling;Molecular;Molecular Biology;Molecular Conformation;Mutation Analysis;National Institute of Diabetes and Digestive and Kidney Diseases;Nature;novel;Nucleic Acids;Nutritional;Oligonucleotides;Oligosaccharides;Plant Viruses;Play;prevent;protein folding;Proteins;Publishing;recruit;Research;Resolution;response;Retroviridae;RNA;RNA Binding;RNA-targeting therapy;RNase P;single-molecule FRET;small molecule;Specificity;spleen exonuclease;Starvation;Stress;structural biology;structural determinants;Structure;sugar;System;targeted treatment;Thermodynamics;trafficking;transcription termination;Transfer RNA;Translation Initiation;Translations;triple helix;Untranslated RNA;Virus Diseases;Work;Yeasts

PROJECT_TITLE: Noncoding RNA structures and interactions in cellular stress responses and immunity


NIH_SPENDING_CATS: Diabetes;Nutrition;Obesity;Prevention

PI_NAMEs: SHERMAN, ARTHUR  (contact)

PROJECT_TERMS: Adolescence;Africa;African;Agreement;Apoptosis;bariatric surgery;base;Behavior;Beta Cell;Blood Glucose;blood glucose regulation;Caloric Restriction;Cell Physiology;Chronic;Clinical Research;Closure by clamp;Collaborations;Compensation;cost;cost effective;Data;design;Deterioration;Diabetes Mellitus;diabetes pathogenesis;diabetes risk;Diagnosis;Diagnostic;diagnostic criteria;Disease;disease model;Ethnic Population;Etiology;European;experience;Far East;fasting glucose;Feedback;Glucose;Glucose Clamp;glucose tolerance;Goals;Homeostasis;Hour;Human;Hyperglycemia;Hyperinsulinism;Immigrant;indexing;Individual;Infusion procedures;Insulin;Insulin Resistance;insulin secretion;insulin sensitivity;International;Intervention;intravenous glucose tolerance test;Investigation;mathematical model;Measures;Mediating;Modeling;National Institute of Diabetes and Digestive and Kidney Diseases;Non-Insulin-Dependent Diabetes Mellitus;Obesity;OGTT;Parameter Estimation;Participant;Pathogenesis;Pathway interactions;Persons;Physiology;Population;Prediabetes syndrome;Prevalence;prevent;Prevention;Process;Public Health;Publishing;Regulation;Reporting;Resistance;Resolution;response;Risk Factors;Rodent;Sampling;screening;Severities;Source;Standard Model;Structure of beta Cell of islet;Thinness;Time;Work

PROJECT_TITLE: Modeling Pathogenesis of Type 2 Diabetes


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

PI_NAMEs: BAX, ADRIAAN  (contact)

PROJECT_TITLE: Study of protein folding and misfolding by NMR spectroscopy


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Biodefense and Related Countermeasures;Biotechnology;Brain Disorders;Clinical Research;Coronaviruses;Coronaviruses Therapeutics and Interventions;Dementia;Emerging Infectious Diseases;Genetics;Infectious Diseases;Neurodegenerative;Neurosciences;Parkinson's Disease

PI_NAMEs: YE, YIHONG  (contact)

PROJECT_TERMS: 2019-nCoV;3-Dimensional;ACE2;Actins;Affinity;alpha synuclein;Alternative Therapies;analog;Astrocytes;Binding;Biological Assay;Brain;breakthrough infection;candidate identification;Cell fusion;Cell membrane;Cell surface;Cell Surface Receptors;Cells;Charge;Chemicals;chemokine;Classification;Complement;Complex;COVID-19 pandemic;cytokine;cytotoxicity;Development;Disease;DNA Topoisomerases;dopaminergic neuron;dorsal motor nucleus;drug repurposing;Drug Targeting;Embryo;Endocytosis;Endoplasmic Reticulum;extracellular;Family;FDA approved;Fluorescence;Gene Expression Profile;Gene Expression Profiling;Glycosaminoglycans;Goals;Golgi Apparatus;graph neural network;Health;Heparan Sulfate Proteoglycan;Heparitin Sulfate;Human;In Vitro;Infection;Inflammatory;inhibitor;Integrins;knock-down;Label;late endosome;Lewy Bodies;Ligation;Lung;Lysosomes;Mammalian Cell;Maps;MAPT gene;Mediating;Membrane;Membrane Proteins;Metalloproteases;Methods;misfolded protein;Mitoxantrone;Modeling;Network-based;Neurodegenerative Disorders;Neuroglia;neuron loss;Neurons;neurotoxic;neurotransmission;new therapeutic target;Nucleosomes;olfactory bulb;Parkinson Disease;Pathologic;Pathology;Pathway interactions;Patients;Pattern;Peptide Signal Sequences;Pharmaceutical Preparations;Physiological;PIK3CG gene;polypeptide;pre-formed fibril;prion hypothesis;Process;protein aggregation;Protein Export Pathway;Protein Secretion;Proteins;Proteomics;proteotoxicity;Quality Control;receptor;recruit;Reporting;Research Project Grants;response;SARS-CoV-2 entry inhibitor;SARS-CoV-2 spike protein;sensor;severe COVID-19;Signal Transduction;Stereotyping;Subgroup;Surface;synuclein;System;tau aggregation;tau Proteins;Tauopathies;Tissues;Topoisomerase Inhibitors;Toxic effect;Training;transcriptome sequencing;transmission process;Transplantation;ubiquitin isopeptidase;Up-Regulation;uptake;Vaccines;Viral;viral entry inhibitor;virtual;Virus;Virus Diseases;Work

PROJECT_TITLE: Unconventional protein secretion-mediated protein quality control in health and diseases


PROJECT_TERMS: Adult;Alzheimer's Disease;Attenuated;Autophagocytosis;Cell Differentiation process;Cell membrane;Cells;Chemicals;Co-Immunoprecipitations;Collection;COS-7 Cell;Coupled;Defect;Drosophila genus;Endoplasmic Reticulum;Endosomes;Eukaryotic Cell;Excision;exosome;Extracellular Space;extracellular vesicles;Failure;Family member;fly;Functional disorder;Goals;Heat shock proteins;Homeostasis;human disease;Inherited;inhibitor;knock-down;late endosome;Lead;Lipofuscin;Lysosomes;Mammalian Cell;Mediating;member;Membrane Fusion;Membrane Proteins;Methods;misfolded protein;Modeling;Molecular Chaperones;multicatalytic endopeptidase complex;mutant;Mutation;Nerve Degeneration;Neurodegenerative Disorders;Neuronal Ceroid-Lipofuscinosis;Neurons;neurotoxic;Nuclear;overexpression;Parkinson Disease;Pathway interactions;Patients;Physiological;polypeptide;Population;Process;Proliferating;protein degradation;Protein Family;protein folding;Protein Isoforms;protein misfolding;Protein Secretion;Protein translocation;Proteins;Proteomics;proteostasis;proteotoxicity;Quality Control;receptor;Reporting;Research Project Grants;Role;Route;secretion process;Serum;SNAP23 gene;Stains;Starvation;Stress;Surface;Synapses;synuclein;tau Proteins;transmission process;Triage;Ubiquitin;ubiquitin isopeptidase;Variant;Vesicle;Western Blotting

PROJECT_TITLE: Roles of protein misfolding in neurodegenerative diseases


NIH_SPENDING_CATS: Bioengineering;Data Science;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

PROJECT_TERMS: Algorithm Design;Algorithmic Analysis;Algorithms;AQP1 gene;Atlases;Back;Biological;Biological Assay;Biological Models;Biology;Black Box;Bladder;Cell Cycle;Cell Differentiation process;Cell Physiology;cell type;Cells;Characteristics;Classification;Compensation;Computing Methodologies;cost;Data;Data Analyses;data complexity;Data Set;deep learning;deep learning model;density;Development;Dimensions;Dropout;Drosophila genus;dynamic system;Endothelial Cells;Equation;experimental study;Gene Expression;generative models;Genes;Genetic Transcription;Goals;graph neural network;Hand;Heart;Heterogeneity;high dimensionality;Human;human tissue;improved;indexing;insight;learning network;Maps;mathematical model;Measurement;Measures;Methods;Modeling;models and simulation;Morphologic artifacts;multidimensional data;Mus;Noise;novel;Output;Pattern;Performance;Probability;Probability Learning;response;Reverse engineering;RNA;screening;simulation;single-cell RNA sequencing;Sodium Chloride;Speed;Stress;Techniques;Testing;Time;Tissues;Training;transcriptome sequencing;Variant;water channel

PROJECT_TITLE: Single Cell Data Analysis Algorithms


NIH_SPENDING_CATS: Biotechnology;Genetics

PI_NAMEs: MCJUNKIN, KATHERINE  (contact)

PROJECT_TERMS: adenylate;Animals;Behavior;Biogenesis;Biological;Biological Models;Biological Process;Biology;Caenorhabditis elegans;Caffeine;Catalysis;Cell Lineage;Cessation of life;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;CRISPR/Cas technology;Development;Disease;Embryo;Embryonic Development;Equilibrium;Exhibits;Family;Gene Expression;Gene Expression Regulation;Gene Silencing;Genes;Genetic;genome editing;insight;Malignant Neoplasms;Mediating;member;Messenger RNA;MicroRNAs;model organism;Modification;Molecular;Mutagenesis;mutant;Mutation;Names;novel;Nucleotides;Organism;Pathway interactions;Phenotype;Physiological Processes;Plants;Play;Post-Transcriptional Regulation;pressure;programs;Proteins;Regulation;Research;Ribonuclease H;RNA;RNA Interference;Role;Stereotyping;Therapeutic;Time;Tissue Differentiation;tool;Untranslated RNA;uridylate

PROJECT_TITLE: Biological functions and post-transcriptional regulation of microRNAs


NIH_SPENDING_CATS: Biomedical Imaging;Chronic Liver Disease and Cirrhosis;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Hepatitis;Hepatitis - B;Hepatitis - C;Infectious Diseases;Liver Disease

PI_NAMEs: KOH, CHRISTOPHER  (contact)

PROJECT_TERMS: Adult;Annual Reports;Ascites;Biochemical;Caring;Chronic Hepatitis B;Chronic Hepatitis C;Chronic Hepatitis D;chronic liver disease;Chronic viral hepatitis;Cirrhosis;Clinic;Clinical;clinical center;Clinical Trials;cohort;Combined Modality Therapy;Communities;Congresses;Data;Data Analyses;deep learning model;Disease;Dose;Effectiveness;elastography;Enrollment;experience;Farnesyl Transferase Inhibitor;FDA approved;Fibrosis;Follow-Up Studies;Goals;Hepatitis B;Hepatitis C;Hepatitis C virus;Hepatitis D;Hepatitis Delta Virus;Hepatology;human subject;Individual;Infection;Injury;Institutional Review Boards;Interferons;International;Journals;Knowledge;Liver;Liver diseases;Lonafarnib;Manuscripts;mathematical model;Measures;Medical;meetings;Methods;Modality;Monitor;National Institute of Diabetes and Digestive and Kidney Diseases;novel;novel therapeutics;open label;Outcome Study;Patient Participation;Patients;Peer Review;peginterferon alfa-2a;Performance;Pharmaceutical Preparations;Phase;Placebos;primary outcome;Principal Investigator;Process;Protease Inhibitor;Publications;Publishing;Radiology Specialty;Reporting;Research;Research Personnel;response;Risk;Ritonavir;Safety;Scanning;serological marker;Serology;Site;Spleen;Staging;success;Therapeutic;Therapeutic Trials;tool;treatment response;United States National Institutes of Health;vibration;Viral;Viral hepatitis;viral RNA;Virus Diseases;Work;X-Ray Computed Tomography

PROJECT_TITLE: Management and Treatment of Chronic Delta Hepatitis Infection and other Liver Diseases


NIH_SPENDING_CATS: Emerging Infectious Diseases;Genetics;Infectious Diseases

PI_NAMEs: HINTON, DEBORAH M (contact)

PROJECT_TERMS: Alleles;Anti-Bacterial Agents;arms race;Bacterial Antibiotic Resistance;Bacterial RNA;Bacteriophage T4;Bacteriophages;Biological;Biology;dark matter;Development;Environment;Equilibrium;Family;Fluorescence;gene product;Genes;genetic information;Growth;Homologous Gene;Impairment;improved;Infection;interest;Laboratories;Mediating;Mediation;Messenger RNA;Molecular Chaperones;mRNA Expression;mutant;novel;nuclease;overexpression;Post-Transcriptional Regulation;posttranscriptional;Process;protein folding;Proteins;Reporter;repository;Resources;rho;Ribonucleases;RNA;RNA Binding;RNA-Binding Proteins;System;termination factor;transcription termination;Work

PROJECT_TITLE: Host Takeover by Bacteriophage T4


NIH_SPENDING_CATS: Diabetes;Genetics;Human Genome;Obesity;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PROJECT_TERMS: Abnormal Karyotype;Adult;Affect;Alleles;Alpha Cell;Beta Cell;Binding;Biological Assay;Biological Models;Catalogs;CDKN1C gene;Cell Differentiation process;Cell Line;cell type;Cells;channel blockers;Clone Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Collecting Cell;Communities;CRISPR/Cas technology;Data;Development;Diabetes Mellitus;diabetes risk;Diazoxide;Dideoxy Chain Termination DNA Sequencing;Disease;disease model;Endocrine;endocrine pancreas development;Enhancers;fetal;Flow Cytometry;Gene Combinations;Gene Expression;Gene Expression Profiling;Gene Expression Regulation;Genes;Genetic;genetic variant;genomic locus;Glucose;glucose metabolism;glucose tolerance;Goals;H19 gene;Haplotypes;Heterozygote;High birth weight infant;Human;human induced pluripotent stem cells;Hyperinsulinism;Hypermethylation;Hypoglycemia;imprint;in utero;Indigenous American;indigenous community;Individual;induced pluripotent stem cell;infancy;Inherited;INS gene;Insulin;insulin regulation;insulin secretion;Introns;islet;Islets of Langerhans;Lead;Linkage Disequilibrium;Maps;Methylation;Modeling;Molecular;Mutation;mutation correction;Non-Insulin-Dependent Diabetes Mellitus;Obesity;Pancreas;Parents;Pathogenesis;Phenotype;pluripotency;prevent;Privatization;Procedures;progenitor;programs;Protocols documentation;Reporting;Research Design;response;Risk;risk variant;RNA analysis;Signal Transduction;single-cell RNA sequencing;Site;Structure of beta Cell of islet;System;Therapeutic Agents;therapeutic evaluation;Therapeutic Intervention;Time;Tissues;Tolbutamide;tool;transcriptome sequencing;transcriptomics;Translating;TRPM5 gene;Variant

PROJECT_TITLE: Differentiation of human induced pluripotent stem cells as a tool to study the effects of type 2 diabetes loci.


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Coronaviruses;Emerging Infectious Diseases;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza;Sleep Research

PROJECT_TITLE: Observation and quantification of respiratory droplets by laser light scattering


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Cancer;Cancer Genomics;Coronaviruses;Coronaviruses Vaccines;Emerging Infectious Diseases;Genetics;Hematology;Human Genome;Immunization;Infectious Diseases;Lymphatic Research;Lymphoma;Prevention;Rare Diseases;Vaccine Related

PI_NAMEs: HENNIGHAUSEN, LOTHAR  (contact)

PROJECT_TERMS: 2019-nCoV;ACE2;Address;Adult-Onset Still's Disease;Affect;Agammaglobulinaemia tyrosine kinase;Alternative Splicing;Antibodies;Antibody Formation;Antibody Response;Austria;B-Lymphocytes;Biomedical Research;Blood;Blood specimen;booster vaccine;cancer transplantation;cell type;Cells;Chronic Lymphocytic Leukemia;Classification;Clinical;clinical practice;Clinical Research;Complete Blood Count;computerized tools;COVID-19;COVID-19 pandemic;COVID-19 patient;COVID-19 prevention;COVID-19 vaccination;cytokine release syndrome;Data;diagnostic tool;Disease;Dose;Effectiveness;Europe;Event;Exhibits;experience;experimental study;FDA Emergency Use Authorization;Flare;Gene Expression;Gene Expression Profiling;Genes;genetic signature;Genetic Transcription;genome-wide;Germany;Human;Immune;immune activation;Immune response;Immune system;Immune System Diseases;Immunity;Immunize;Immunocompromised Host;immunological status;Immunologics;improved;In Vitro;Individual;individual response;Infection;Inflammation;Inflammatory Response;inhibiting antibody;inhibitor;insight;Interferons;International;international partnership;Italy;Janus kinase;Kidney;kinase inhibitor;leukemia;leukemia treatment;Link;Logistics;Lung;Lymphocyte Depletion;male;Mediating;Messenger RNA;Methods;Mus;Mutation;neutralizing antibody;neutrophil;organ transplant recipient;pandemic disease;pathogen;Pathway interactions;Patients;Pattern;Persons;Pfizer-BioNTech COVID-19 vaccine;Population;Population Group;Prevalence;Production;Publishing;receptor;receptor binding;Recording of previous events;Recovery;Reporting;Research;response;RNA analysis;Safety;Sampling;SARS-CoV-2 B.1.1.529;SARS-CoV-2 exposure;SARS-CoV-2 immune response;SARS-CoV-2 infection;SARS-CoV-2 variant;Sequence Alignment;Severity of illness;Signal Pathway;Signal Transduction;Small-Cell Lymphoma;South Korea;Spliced Genes;symptomatology;System;T cell response;T-Cell Receptor;T-cell receptor repertoire;Therapeutic Uses;tool;tositumomab;transcriptome;transcriptome sequencing;Tyrosine Kinase Inhibitor;United States Food and Drug Administration;Vaccination;Vaccinee;Vaccines;vaccinology;Variant;vector-based vaccine;Viral;Virus

PROJECT_TITLE: COVID-19: immune response and systems vaccinology


PI_NAMEs: CHELOHA, ROSS  (contact)

PROJECT_TERMS: Address;Adenosine;Affect;Alpaca;Angiotensin Receptor;Animal Model;Antibodies;antibody conjugate;Binding;Biological;Biological Assay;Biology;Camels;Cell Surface Proteins;Cell Surface Receptors;Cells;Characteristics;Chemicals;Chemistry;chronic pain;design;Development;Diabetes Mellitus;Disease;Exhibits;G-Protein-Coupled Receptors;GLP-I receptor;Goals;Immune system;In Vitro;Inflammation;interest;Llama;Mammalian Cell;Marriage;Methodology;Methods;Muscarinic Acetylcholine Receptor;nanobodies;novel strategies;Organic Chemistry;Osteoporosis;Peptides;pharmacologic;Pharmacologic Substance;Physiological;Process;Property;protein function;Proteins;Reagent;receptor;receptor function;response;small molecule;Specificity;Surface;TACR1 gene;Testing;Therapeutic;tool;unnatural amino acids

PROJECT_TITLE: New tools from chemistry and antibodies to address receptor function


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Prevention;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PI_NAMEs: NARAYAN, PRIYANKA  (contact)

PROJECT_TERMS: Acceleration;Address;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;apolipoprotein E-4;Area;Astrocytes;Biochemistry;cell type;Chemicals;Collaborations;Development;Disease;disorder risk;Environmental Risk Factor;Genetic;glial activation;Human;human induced pluripotent stem cells;induced pluripotent stem cell;lipid metabolism;Lipids;Mediating;metabolomics;Microglia;Molecular;Molecular Biology;Motility;mutant;mutation screening;Netherlands;Neurodegenerative Disorders;Neuroglia;neuroinflammation;Neurons;novel;novel therapeutics;Pathway interactions;patient population;Predisposition;prevent;Prevention strategy;Process;protective allele;Public Health;Research;Research Personnel;resilience;Risk;Risk Factors;Role;Shapes;Therapeutic;trafficking;United States National Institutes of Health;Variant;ward;Work

PROJECT_TITLE: Investigating the molecular basis of risk and resilience to Alzheimer's disease


NIH_SPENDING_CATS: American Indian or Alaska Native;Childhood Obesity;Clinical Research;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Microbiome;Nutrition;Obesity;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

PI_NAMEs: SINHA, MADHUMITA  (contact)

PROJECT_TERMS: 18 year old;Adolescence;adverse pregnancy outcome;Age Years;Alaska Native;American Indians;Area;Arizona;Award;Barker Hypothesis;Belief;bench to bedside;Biochemical;Biological Factors;Biological Markers;Birth;Birth Weight;Body Composition;Body mass index;Child;Childbirth;Childhood;Clinical;cohort;Communities;Consent;Data;Diabetes Mellitus;diabetes risk;diabetic;early childhood;Enrollment;Environmental Risk Factor;epidemiology study;Ethnic Population;experience;Exposure to;Family;Fatty Liver;Frequencies;Future;Genetic;gestational weight gain;Goals;Grant;Growth;gut microbiome;Health;health determinants;Health Policy;Health Status;High Prevalence;high risk;high risk population;Hispanic;Hispanic Americans;Indigenous American;infancy;Infant;Inflammatory;innovation;Institutional Review Boards;Intramural Research Program;intrauterine environment;Life;Life Cycle Stages;lifestyle factors;Longitudinal cohort;Longitudinal Studies;maternal risk;Mediating;Metabolic;metabolic profile;metabolome;methylome;metropolitan;microbiome composition;Molecular;Mothers;National Institute of Diabetes and Digestive and Kidney Diseases;Native Americans;neurodevelopment;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;obesity in children;offspring;Participant;Pattern;phenotypic data;Placenta;Population;Population Group;Postpartum Period;predictive modeling;Pregnancy;Pregnant Women;prenatal;prepregnancy;prevent;Proteome;Psychosocial Factor;recruit;Research;Risk;Risk Factors;Role;Serum;Socioeconomic Factors;Southwestern United States;transcriptome;Umbilical Cord Blood;United States National Institutes of Health;Urban Community;Visit;Weight

PROJECT_TITLE: Epidemiologic studies of maternal and early life metabolic risk


NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Telehealth

PROJECT_TERMS: 10 year old;Active Learning;Address;Adult;Affect;Alaska Native;American Indians;Award;Behavior Therapy;bench to bedside;Caregivers;Child;Clinic;Collaborations;Colorado;Communities;community-level factor;COVID-19 impact;COVID-19 pandemic;COVID-19 pandemic effects;Data Analyses;Data Collection;Diabetes Mellitus;diabetes risk;Educational Curriculum;Enrollment;Ethnic Population;experience;fatty liver disease;Funding;Future;genetic variant;Grant;gut microbiota;Health;Health behavior;Hispanic Populations;Hybrids;improved;Incidence;Individual;intervention program;Learning;lifestyle intervention;Mediating;Metabolic;microbial;minority children;Morbid Obesity;motivational enhancement therapy;National Institute of Diabetes and Digestive and Kidney Diseases;native youth;Navajo;non-alcoholic fatty liver disease;Obesity;obesity in children;obesity prevention;open data;operation;Outcome Study;Overweight;pandemic disease;Parents;Participant;participant enrollment;patient engagement;Persons;Prevalence;primary caregiver;Procedures;Process;programs;Publications;racial minority population;Randomized, Controlled Trials;Regulation;remote delivery;remote visit;Research;Reservations;resilience;Risk Factors;Role;Rural;Safety;Sampling;Schedule;Site;Susceptibility Gene;Tribes;United States;United States National Institutes of Health;Universities;Variant;virtual;Visit;Youth

PROJECT_TITLE: Diabetes/obesity prevention in youth


PI_NAMEs: PERIWAL, VIPUL  (contact)

PROJECT_TERMS: 3-Dimensional;Address;Agreement;Algorithms;Alpha Cell;Animals;Architecture;Auxins;Beta Cell;Biological;cell type;Characteristics;Chromatin Loop;Chromosomes;cohesin;Collection;complex data;Computer software;Consumption;cost;D Cells;Data;Data Analyses;Data Set;Development;Diabetes Mellitus;DNA;Endocrine;Energy Metabolism;Equilibrium;Fatty acid glycerol esters;Functional disorder;Genes;Genome;genome-wide;Genomics;Glucagon;Glucose;graph theory;Hi-C;Hormone secretion;Hour;Human Genome;Image;Impairment;improved;Insulin;interest;Interruption;islet;Islets of Langerhans;large datasets;Location;Manuals;Maps;Memory;Metabolic;Methods;multidimensional data;nerve supply;Noise;novel;Organ;Pattern;Process;Property;protein complex;Pythons;Regulation;Resolution;Running;Science;Signal Transduction;statistics;Structure;System;Three-Dimensional Imaging;Time;tool;two-dimensional;user-friendly;Vascularization;Work

PROJECT_TITLE: Computing persistent homology in biological datasets


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Genetics;Infectious Diseases;Lung

PI_NAMEs: YANG, WEI  (contact)

PROJECT_TERMS: 2019-nCoV;ATP Hydrolysis;Base Pairing;betacoronavirus;Binding;Biochemical;Biological Assay;C-terminal;Catalytic Domain;Cell Separation;Cells;Cessation of life;Charge;Classification;Clinical Trials;Colorado;Complex;Coronavirus;Coupled;COVID-19;COVID-19 pandemic;COVID-19 treatment;Cryoelectron Microscopy;Data;Dengue Fever;design;Disease Outbreaks;DNA;DNA Primase;ds-DNA;foot;Future;Genes;Genetic Transcription;Genome;Goals;helicase;Hepatitis C;Human;Human poliovirus;improved;In Vitro;in vivo;Individual;Infection;inhibitor;International;Left;Maps;Membrane;Middle East Respiratory Syndrome;Middle East Respiratory Syndrome Coronavirus;Modeling;Molecular;movie;Mus;Names;Nonstructural Protein;novel coronavirus;Nucleic Acids;Open Reading Frames;pandemic disease;Papain;Pathogenesis;Patients;Peptide Hydrolases;Persons;Pharmaceutical Preparations;Polyproteins;Postdoctoral Fellow;Power stroke;Preparation;prevent;Process;protein purification;Proteins;remdesivir;Reporting;Rhinovirus;RNA;RNA chemical synthesis;RNA Helicase;RNA replication;RNA Viruses;RNA-Directed RNA Polymerase;SARS coronavirus;Science;Severe Acute Respiratory Syndrome;Small RNA;Specificity;Structural Genes;Structure;Symptoms;Taxonomy;Testing;Time;United States National Institutes of Health;Vaccines;Vesicle;Viral;Viral Physiology;viral RNA;Viral Structural Proteins;Virion;Virus;Virus Assembly;Virus Diseases;Virus Inhibitors;Virus Replication;Visit;X-Ray Crystallography;Yellow fever virus

PROJECT_TITLE: Characterization of replication and transcription of SARS-CoV-2


NIH_SPENDING_CATS: Clinical Research;Rare Diseases

PI_NAMEs: BROWN, REBECCA  (contact)

PROJECT_TERMS: Adipose tissue;antagonist;Appearance;Dyslipidemias;Fasting;Fatty acid glycerol esters;Glycerol;Goals;Growth Hormone Receptor;Insulin Receptor;Insulin Resistance;Insulin-Like Growth Factor I;Lipodystrophy;Lipolysis;Measures;Mediating;Metabolic Diseases;non-alcoholic fatty liver disease;Nonesterified Fatty Acids;Palmitates;Pathogenicity;Patients;pegvisomant;Rare Diseases;recruit;Somatotropin;subcutaneous;Variant

PROJECT_TITLE: Growth hormone inhibition in severe insulin resistance