NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Clinical Research;Eye Disease and Disorders of Vision;Neurosciences

PI_NAMEs: CONWAY, BEVIL  (contact)

PROJECT_TERMS: Anatomy;Animals;Anterior;Area;Auditory;Banana;Behavior;Behavioral;Biological Models;Brain;Brain imaging;Categories;Cells;Cerebral cortex;Characteristics;Child;Cognition;Cognitive;cognitive process;Cognitive Science;Color;color category;comparative;comparison group;Complex;Computer Models;Concept Formation;Cone;Consensus;convolutional neural network;Cues;Data;Data Set;Ear;Emotions;experience;experimental study;extrastriate visual cortex;Eye;fovea centralis;Frequencies;Functional Magnetic Resonance Imaging;gaze;Goals;Heart;Human;Image;Individual;Inferior;information processing;Investments;Journals;Knowledge;Language;large datasets;Learning;Likelihood Functions;Macaca;Magnetic Resonance Imaging;Maps;Measures;meetings;Memory;Methods;Microelectrodes;microstimulation;Mind;Modeling;Monkeys;movie;neural;neuroethology;neuroimaging;Neurons;neurophysiology;Neurosciences;Noise;non-verbal;nonhuman primate;object shape;Paper;Pattern;Perception;Persons;pharmacologic;Photoreceptors;Physiological;Play;Population;Positioning Attribute;Primates;Process;programs;psychologic;Psychophysics;Publications;Publishing;receptive field;Redness;Research;Research Personnel;Research Technics;Resolution;response;Retina;retinotopic;Reverse engineering;Role;Sampling;Scanning;Science;science and society;Sensory;Shapes;Signal Transduction;social cognition;Societies;Source;spatiotemporal;Stimulus;Strawberries;Structure;Temporal Lobe;Testing;Thinking;tool;trend;ventral visual stream;Vision;vision science;Visual;Visual Cortex;Visual Fields;Visual Pathways;visual processing;visual search;visual stimulus;visual tracking;Visualization;Work

PROJECT_TITLE: Using Color as a Model System for studying Perception, Thoughts, and Action


ACTIVITY: ZIA

ADMINISTERING_IC: EY

ARRA_FUNDED: N

FUNDING_MECHANISM: INTRAMURAL RESEARCH

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Clinical Research;Clinical Trials and Supportive Activities;Eye Disease and Disorders of Vision;Genetics;Macular Degeneration;Neurodegenerative;Neurosciences

ORG_NAME: NATIONAL EYE INSTITUTE

PI_NAMEs: CHEW, EMILY Y (contact)

PROJECT_TERMS: Addendum;Age related macular degeneration;Biological Markers;Biological Specimen Banks;biomarker identification;Blindness;British;Certification;Classification;Classification Scheme;Clinic;clinical research site;Data;Data Analyses;Derivation procedure;Development;Elderly;Eligibility Determination;Equipment;Future;Genetic Determinism;genetic information;Genotype;Human Resources;Image;Imaging technology;Institutional Review Boards;international center;Leadership;Longitudinal Studies;Measurement;Multicenter Studies;Natural History;operation;oral supplementation;Outcome;Participant;Patient Recruitments;Patients;Phase II Clinical Trials;Phenotype;Reading;recruit;Research Personnel;Resources;Retina;serial imaging;Site;Standardization;System;Therapeutic;United States;United States National Institutes of Health;Vision;vision development

PROJECT_TITLE: AMD Ryan Initiative Study (ARIS)


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences;Rare Diseases

PI_NAMEs: CUKRAS, CATHERINE  (contact)

PROJECT_TERMS: Agreement;Clinical;clinical outcome measures;Clinical Trials;design;Diagnosis;Disease Progression;Electroretinography;Enrollment;Evaluation;Functional disorder;functional outcomes;Future;Goals;imaging modality;Intervention;Kinetics;Length;macula;Maps;Measures;Nature;neuroinflammation;novel;Optical Coherence Tomography;Outcome Measure;Participant;Patients;Perimetry;photoreceptor degeneration;Photoreceptors;primary outcome;Process;Psychophysics;Quantitative Evaluations;Retina;Retinitis Pigmentosa;scaffold;secondary outcome;Severities;study population;Surveys;Testing;Therapeutic Intervention;Thick;Time;Transplantation;Visual Acuity;Visualization

PROJECT_TITLE: A Survey study of Retinitis Pigmentosa (RP) clinical measures and repeatability testing of potential outcome measures


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Congenital Structural Anomalies;Eye Disease and Disorders of Vision;Genetic Testing;Genetics;Human Genome;Macular Degeneration;Neurodegenerative;Neurosciences;Pediatric;Rare Diseases

PI_NAMEs: GUAN, BIN  (contact)

PROJECT_TERMS: achromatopsia;Albinism;Aniridia;Anophthalmos;Autosomal Dominant Optic Atrophy;Axenfeld-Rieger syndrome;bioinformatics pipeline;Blood;blue cone monochromacy;causal variant;Cell Line;Choroideremia;Classification;CLIA certified;Clinic;Clinical;clinical care;clinical center;clinical phenotype;Clinical Protocols;Clinical Services;cohort;Collaborations;Coloboma;cone-rod dystrophy;Corneal dystrophy;Data;Data Set;design;Development;Diagnostic tests;Dideoxy Chain Termination DNA Sequencing;digital;Disease;DNA;epigenomics;exome;exome sequencing;Extramural Activities;Frequencies;functional genomics;Genes;Genetic;genetic testing;Genome;genome sequencing;Genomics;Goals;Heritability;Human;improved;in silico;Individual;insertion/deletion mutation;Laboratories;Leber's Hereditary Optic Neuropathy;malformation;meetings;Microphthalmos;Mitochondrial DNA;Molecular;molecular diagnostics;Molecular Genetics;next generation sequencing;Night Blindness;novel;Outsourcing;Patients;pattern dystrophies;programs;Protocols documentation;Publishing;recruit;Reporting;Research;Retinal Degeneration;Retinitis Pigmentosa;Sampling;segregation;Single Nucleotide Polymorphism;Site;Skin;Sorsby's fundus dystrophy;Stargardt's disease;Stickler syndrome;Testing;tool;Usher Syndrome;Variant;variant of unknown significance;Vision Disorders;Vitelliform macular dystrophy;X-Linked Retinoschisis

PROJECT_TITLE: Clinical ophthalmic molecular diagnostics and discovery


NIH_SPENDING_CATS: Biotechnology;Congenital Structural Anomalies;Eye Disease and Disorders of Vision;Genetics;Human Genome;Pediatric

PI_NAMEs: HUFNAGEL, ROBERT  (contact)

PROJECT_TERMS: Address;Affect;Animal Model;Area;ATAC-seq;Bibliography;Biological Models;Birds;Blindness;BMPR1A gene;candidate validation;causal variant;Cell Line;Cell model;Cells;Cellular biology;Child;Childhood;Code;Collaborations;congenital vision disorder;CRISPR/Cas technology;Data;Development;Developmental Biology;Diagnostic;Disease;Dysplasia;Education;Employment;epigenomics;Eye;Eye diseases;fovea centralis;Frequencies;functional genomics;gene therapy;Generations;Genes;Genetic;Genetic Screening;genetic testing;genetic variant;Genetic Variation;Genome;genomic locus;genomic platform;genomic variation;Genomics;Goals;Hereditary Disease;Heritability;Hi-C;Human;human disease;human model;In Vitro;induced pluripotent stem cell;Investigation;Knowledge;Laboratories;Live Birth;Lizards;Machine Learning;macula;malformation;Maps;Medical Genetics;Medicine;Modeling;Molecular;Molecular Biology;Molecular Diagnosis;molecular diagnostics;Morbidity - disease rate;Morphology;Mus;Neural Retina;novel;novel strategies;Pathogenicity;Patients;Population;Population Study;preclinical study;prevent;Primates;programs;Proteins;public database;Replacement Therapy;Research;Retinal Degeneration;RNA-Binding Proteins;Science;Shock;single cell sequencing;Sumoylation Pathway;Syndrome;Techniques;Technology;Tissues;transcriptome sequencing;transcriptomics;Untranslated RNA;Variant;Vision;Work;Zebrafish

PROJECT_TITLE: Genomic and epigenomic mechanisms of pediatric ocular disorders


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Eye Disease and Disorders of Vision;Neurosciences;Patient Safety

PROJECT_TERMS: Affect;Anatomy;Area;Blindness;Cells;Ciliary Neurotrophic Factor;Clinic;Clinical Trials;Controlled Clinical Trials;Degenerative Disorder;design;Deterioration;Diabetic Retinopathy;Diagnosis;Disease;Disease Progression;Early treatment;effective therapy;efficacy evaluation;Eligibility Determination;Encapsulated;Enrollment;Exclusion Criteria;Eye;follow-up;Goals;Image;Implant;Intervention;Intervention Studies;Letters;macula;Masks;Measures;Multicenter Studies;Multicenter Trials;Operative Surgical Procedures;Ophthalmologist;Outcome Measure;Participant;Perimetry;Persons;Pharmacologic Substance;Phase;phase 3 study;Phase I Clinical Trials;Phase II Clinical Trials;phase II trial;Phase III Clinical Trials;phase III trial;Photoreceptors;placebo group;Placebos;primary endpoint;primary outcome;Questionnaires;Randomized;rate of change;Reading;Reporting;Retina;Safety;safety testing;screening;secondary outcome;Serious Adverse Event;sham surgery;sham-controlled study;Signal Transduction;Site;Speed;study population;Surgeon;Surgical complication;Telangiectasis;Telephone;Testing;Thick;treatment group;Vision;Visual Acuity

PROJECT_TITLE: A Phase 3 Multicenter, Randomized, Sham-Controlled Study to Determine the Safety and Efficacy of Renexus in Macular Telangiectasia Type 2


NIH_SPENDING_CATS: Clinical Research;Dietary Supplements;Eye Disease and Disorders of Vision;Neurosciences;Nutrition

PROJECT_TERMS: Adverse reactions;Dark Adaptation;design;Eligibility Determination;Enrollment;Event;improved;Investigation;Kinetics;luminance;Measurement;Measures;Outcome Measure;Participant;Patient Outcomes Assessments;Patients;primary outcome;prospective;Questionnaires;retinyl palmitate;secondary outcome;study population;Supplementation;Visual Acuity

PROJECT_TITLE: An Investigation of Vitamin A Palmitate Supplementation in Patients withAMD and/or Reticular Pseudodrusen (RPD) and Delayed Dark Adaptation


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Emerging Infectious Diseases;Eye Disease and Disorders of Vision;Genetics;Human Genome;Infectious Diseases;Neurodegenerative;Neurosciences

PI_NAMEs: SHIH, HAN-YU  (contact)

PROJECT_TERMS: 3-Dimensional;Alzheimer's Disease;Amyloidosis;Architecture;Autoimmunity;Binding;Binding Sites;Biological;brain parenchyma;CD8-Positive T-Lymphocytes;Cells;Chromatin;Chromatin Loop;cytokine;Cytokine Gene;Development;Dimensions;Disease;disorder prevention;DNA;DNA Methylation;Elements;Engineering;Epigenetic Process;Exhibits;Flow Cytometry;Gene Expression Regulation;Genes;Genome;Genomics;Glaucoma;Helper-Inducer T-Lymphocyte;histone modification;Homeostasis;Host Defense;Human;Immune;Immune response;Immunity;Immunology;immunoregulation;Impairment;Infiltration;insight;Interferon Type I;Interferon Type II;interleukin-22;Knowledge;Lymphocyte;Lymphoid Cell;Mediating;Molecular;mouse model;Mus;Nerve Degeneration;Neurodegenerative Disorders;neuroinflammation;Nucleic Acid Regulatory Sequences;Phenotype;Play;Positioning Attribute;Predisposition;Production;Regulation;Regulatory Element;Research;Role;Science;Signaling Molecule;single-cell RNA sequencing;Site;Specific qualifier value;Stimulus;Synteny;Techniques;Th1 Cells;Tissues;Toxoplasmosis;transcription factor;Variant

PROJECT_TITLE: Genomic regulation of immune response in neurodegeneration in mice


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Data Science;Eye Disease and Disorders of Vision;Machine Learning and Artificial Intelligence;Mental Health;Neurosciences

PI_NAMEs: NIENBORG, HENDRIKJE  (contact)

PROJECT_TERMS: Acoustics;Address;Affect;Anatomy;Animal Behavior;Animals;Area;area striata;Attention;Behavior;behavior influence;behavior prediction;Behavioral;Biological;Brain;Brain region;Cerebral cortex;Characteristics;Cognitive;Collaborations;Communication;Complex;cost;Data;Data Set;Decision Making;Desire for food;Development;dimension reduction;discrimination task;dorsal raphe nucleus;Electrophysiology (science);extrastriate visual cortex;Eye;Eye Movements;Face;Feedback;flexibility;follow-up;Funding;Hand;Hibernation;high dimensionality;Human;improved;Individual;information processing;Knowledge;Learning;learning strategy;Light;Macaca;Machine Learning;Mammals;Measurement;Mental disorders;Modeling;Monkeys;Motion;Motor Activity;Movement;Mus;Nervous System Disorder;neural;Neurobiology;Neuromodulator;Neurons;neurophysiology;neuroregulation;Neurosciences;neurotransmission;optogenetics;Organism;Performance;pharmacologic;Physiological;Primates;Property;Publications;Reporting;Research;response;retinal imaging;Robotics;Rodent;Role;Saccades;sample fixation;Science;selective attention;Sensory;Sensory Process;Serotonergic System;Serotonin;serotonin receptor;Signal Transduction;Spermophilus;statistics;Stimulus;Structure;System;Techniques;Testing;tool;Training;training project;unsupervised learning;vigilance;Vision;Visual;Visual Cortex;visual discrimination;Visual Fields;visual information;visual processing;visual stimulus;vocalization;Work

PROJECT_TITLE: Neural Substrates for Visual Decision Making in the Visual Cortex


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Eye Disease and Disorders of Vision;Networking and Information Technology R&D (NITRD);Neurosciences

PI_NAMEs: JEFFREY, BRETT  (contact)

PROJECT_TERMS: Affect;Assessment tool;Biological Markers;Clinical;clinical outcome measures;Clinical Trials;Clinical Trials Design;Color Visions;Consumption;Contrast Sensitivity;Cross-Sectional Studies;Data;disability;experience;Floor;functional outcomes;Goals;healthy volunteer;Measures;Normal Range;novel;Outcome Measure;Patient Recruitments;Patients;Performance;Perimetry;Photosensitivity;Protocols documentation;Reality Testing;recruit;Retinal Diseases;Testing;Time;Training;virtual;virtual reality;Vision;Visual Acuity;Visual Fields;Visual impairment;walking speed

PROJECT_TITLE: An Observational Cross-Sectional Study of Virtual Reality Mobility Assessment of Functional Vision in Retinal Disease


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Eye Disease and Disorders of Vision;Genetics;Neurosciences;Rare Diseases

PROJECT_TERMS: Adolescent;Adverse event;Affect;Antibodies;Blindness;Data;design;Dose;efficacy evaluation;Electroretinography;Enrollment;Eye;first-in-human;follow-up;Gene Transfer;Genes;Genetic;Injections;intravitreal injection;Laboratories;Link;Macular degeneration;male;Measurement;Monitor;Optical Coherence Tomography;Outcome Measure;Participant;Phase;Phase I/II Clinical Trial;primary outcome;prospective;Publishing;response;Retina;Retinal Diseases;retinal imaging;Safety;Sample Size;Scheme;secondary outcome;statistics;Structure;study population;Testing;Transgenes;vector;Vision;Visual Fields;X-Linked Retinoschisis;young man

PROJECT_TITLE: A Phase I/IIa Study of RS1 Ocular Gene Transfer for X-linked Retinoschisis


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Eye Disease and Disorders of Vision;Neurosciences

PROJECT_TERMS: adaptive optics;Affect;Basement membrane;Biological Markers;Cellular Morphology;Cellular Structures;Clinical;cohort;design;Development;Diagnostic Procedure;Disease;Enrollment;Eye diseases;healthy volunteer;human subject;Image;imaging system;instrument;Investigation;Lasers;Location;Longitudinal Studies;multimodality;novel diagnostics;novel therapeutics;Ophthalmoscopy;Optical Coherence Tomography;optical imaging;Outcome Measure;Participant;Pathology;Photoreceptors;primary outcome;protocol development;Protocols documentation;Resolution;Retina;Retinal Diseases;retinal imaging;Scanning;Structure of retinal pigment epithelium;study population

PROJECT_TITLE: Adaptive Optics Imaging of Outer Retinal Diseases


NIH_SPENDING_CATS: Clinical Research;Eye Disease and Disorders of Vision;Macular Degeneration;Neurodegenerative;Rare Diseases

PROJECT_TERMS: Atrophic;Canada;Collaborations;Cross-Sectional Studies;Data;disorder of macula of retina;Enrollment;Family;follow-up;Funding;Funding Agency;Funding Mechanisms;Goals;Institution;macula;member;Mutation;Natural History;Participant;Patient Recruitments;Patients;Phase;Prevalence;prospective;Protocols documentation;Rare Diseases;recruit;Secondary to;Stargardt's disease;Switzerland;Therapeutic;Time;Travel;United States National Institutes of Health;Universities;Visit;Work

PROJECT_TITLE: An Observational Prospective Natural History Study of Stargardt-like Macular Dystrophy (STDG3) Secondary to Mutations in ELOVL4


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Coronaviruses;Emerging Infectious Diseases;Eye Disease and Disorders of Vision;Infectious Diseases;Lung

PI_NAMEs: REDMOND, T. MICHAEL  (contact)

PROJECT_TERMS: 2019-nCoV;ACE2;Amino Acids;Antibodies;Antibody Therapy;Appearance;base;Biochemical;Biochemistry;Blocking Antibodies;Caveolae;caveolin 1;Cell Line;Cell Survival;Cells;Child;China;Cholesterol;Codon Nucleotides;Conjunctivitis;Coronavirus;COVID-19;COVID-19 pandemic;Data;Disease;Dynamin;Dynamin I;economic impact;Endocytosis;Evolution;experimental study;extracellular;Eye;Glycoproteins;Goals;Human;Infection;interest;Knowledge;Lung;Mediating;Membrane;Membrane Microdomains;Morbidity - disease rate;mortality;Mutagenesis;mutant;Mutation;Nonsense Codon;novel;novel coronavirus;ocular surface;Organ;Organoids;particle;Pathway interactions;Peptide Hydrolases;Play;Posterior Uveitis;Process;Property;Protein Biochemistry;protein expression;Proteins;Public Health;Publications;Publishing;receptor;Regulation;Reporting;Rest;Ribosomes;RNA Biochemistry;RNA Sequences;Role;SARS coronavirus;SARS-CoV-2 B.1.1.529;SARS-CoV-2 B.1.617.2;SARS-CoV-2 spike protein;SARS-CoV-2 variant;Site;skills;Small Interfering RNA;Structure;Tertiary Protein Structure;Toxic effect;Transfection;Translations;Variant;Vimentin;Viral Conjunctivitis;Virulence;Virulence Factors;Virus;Vision research;weapons

PROJECT_TITLE: Biochemistry of SARS-CoV-2 Spike Protein and its Ocular Surface Membrane Receptor


NIH_SPENDING_CATS: Clinical Research;Eye Disease and Disorders of Vision

PI_NAMEs: MAGONE, M. TERESA  (contact)

PROJECT_TERMS: Address;Affect;Autoimmune;Biological Assay;Biological Markers;Blood Tests;Calibration;chemokine;Clinic Visits;Clinical;clinical care;clinical examination;Clinical Management;Clinical Research;Collection;Cornea;Custom;cytokine;Diagnosis;Diagnostic;Disease;Dry Eye Syndromes;Enzyme-Linked Immunosorbent Assay;Evaluation;Film;Functional disorder;Growth Factor;healthy volunteer;Hour;Individual;individual patient;Inflammation;Inflammatory;innovation;insight;Lacrimal gland structure;Measurement;Measures;Methods;migration;millimeter;Modification;Monitor;ocular surface;ocular surface disease;Outcome Measure;Paper;Patients;personalized diagnostics;Property;Proteins;Sampling;Sjogren's Syndrome;Standardization;Structure;Syndrome;Systemic Therapy;Testing;tool;Variant

PROJECT_TITLE: Tear film biomarker testing from Schirmer strips as a clinical tool in autoimmune ocular surface disease


NIH_SPENDING_CATS: Data Science;Eye Disease and Disorders of Vision;Networking and Information Technology R&D (NITRD)

PI_NAMEs: MCGAUGHEY, DAVID  (contact)

PROJECT_TERMS: Atlases;Bioconductor;Computer software;Data;data curation;Development;dimension reduction;flexibility;Gene Expression;improved;Knowledge;Learning;Literature;Machine Learning;Metadata;open source;Paper;Publications;Resources;Sampling;tool;Update;Visualization;web app

PROJECT_TITLE: Data Curation and Projection


NIH_SPENDING_CATS: Aging;Clinical Research;Clinical Trials and Supportive Activities;Eye Disease and Disorders of Vision;Macular Degeneration;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Transplantation

PROJECT_TERMS: Adverse event;Age related macular degeneration;Area;Autologous;Autologous Transplantation;Blindness;Cell Therapy;Cells;Clinical Trials;cohort;Data;Elderly;Enrollment;Eye;Fingers;Future;Generations;geographic atrophy;Glycolates;In Vitro;induced pluripotent stem cell;macula;Methods;monolayer;neurosensory;Nonexudative age-related macular degeneration;Operative Surgical Procedures;Outcome Measure;Participant;Patient Recruitments;Phase;phase I/IIa trial;primary outcome;Procedures;Reporting;Retina;Safety;safety and feasibility;scaffold;secondary outcome;Site;stem cell biology;Structure of retinal pigment epithelium;Transplantation;Universities;Visual Acuity;Work

PROJECT_TITLE: A Phase I/IIa Trial for Autologous Transplantation of Induced Pluripotent Stem Cell-Derived Retinal Pigment Epithelium for Geographic Atrophy Associated with Age-Related Macular Degeneration


ACTIVITY: ZIC

ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biotechnology

PI_NAMEs: MORGAN, NICOLE Y (contact)

PROJECT_TERMS: 3-Dimensional;Adoption;Antibodies;Award;Axon;Back;base;bench to bedside;Biochemical;biological systems;biomaterial development;Biomaterials Research;Biomedical Research;CCR;cell motility;Cells;chemokine;Chills;Clinical;Coculture Techniques;Collaborations;Companions;Complement;Consumption;Dedications;density;design;Development;Device Designs;Device or Instrument Development;Devices;Dimensions;Discipline;Elements;Emulsions;Encapsulated;Endothelium;Equipment;exosome;experimental study;Extracellular Matrix;fabrication;Fibroblasts;Fluorescence;Fluorescence Resonance Energy Transfer;Foreign Bodies;Gel;Geometry;Glass;Harvest;Height;high throughput screening;Human Resources;Hydrogels;Hypoxia;Image;Imaging Device;in vitro Model;in vivo;instrument;instrumentation;interest;Intramural Research Program;Knowledge;Laboratories;Length;liposomal formulation;Liquid substance;Macrophage;manufacturing cost;matrigel;Measurement;Mechanics;Membrane;meter;Microfabrication;Microfluidic Microchips;Microfluidics;millimeter;Modeling;Modification;Molds;National Center for Advancing Translational Sciences;National Heart, Lung, and Blood Institute;National Institute of Allergy and Infectious Disease;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;National Institute of Biomedical Imaging and Bioengineering;National Institute of Child Health and Human Development;National Institute of Diabetes and Digestive and Kidney Diseases;National Institute of Neurological Disorders and Stroke;National Institute on Deafness and Other Communication Disorders;Neoplasm Metastasis;Neurons;operation;Operative Surgical Procedures;Oxygen;Patients;Pattern;Pluronics;poly(ethylene glycol)diacrylate;Polymers;pressure;Printing;Process;Protocols documentation;prototype;pulmonary arterial hypertension;Pump;real-time images;Research;Research Personnel;Resected;Resolution;Resource Sharing;response;Robotics;Sampling;SARS-CoV-2 infection;senescence;Sepharose;Sickle Cell Anemia;simulation;Spatial Distribution;stem cells;Structure;Surface;Syringes;System;Techniques;Temperature;Thinness;three dimensional cell culture;Time;tissue culture;Tissues;tool;Training;transcriptomics;United States National Institutes of Health;UV Radiation Exposure;viscoelasticity;With laterality;Work;Zebrafish

PROJECT_TITLE: Microfabrication for Biomedical Research


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Clinical Research;Coronaviruses;Emerging Infectious Diseases;Immunization;Infectious Diseases;Vaccine Related

ORG_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

PI_NAMEs: KALISH, HEATHER  (contact)

PROJECT_TERMS: 2019-nCoV;acrylic acid;Address;Aedes;Aftercare;Antibodies;Automation;Autopsy;B-Lymphocytes;Binding;Biological;Biological Assay;Blood specimen;Calcium;Chlorine;Clinical Research Protocols;Collaborations;Communities;community transmission;Contrast Media;Coupled;COVID-19 mortality;Culicidae;Detection;Development;Diagnosis;Disease;Dose;Enrollment;Enzyme-Linked Immunosorbent Assay;Evaluation;Exhibits;experience;experimental study;Exposure to;Eye;Gel;glycosylated IgG;glycosylation;Goals;Health;Health Personnel;healthy volunteer;Hepatitis C;high throughput analysis;histological stains;HIV;HIV Infections;Human;IgG3;IL7 gene;Image;Immune;Immune response;Immunochemistry;immunodeficiency;immunoengineering;Immunoglobulin A;Immunoglobulin G;Immunoglobulin M;Immunology;immunoregulation;Individual;Inductively Coupled Plasma Mass Spectrometry;Infection;Inflammatory Response;Inherited;instrumentation;interest;Label;Laboratories;Lipids;Manganese;manganese oxide;Manuals;Mass Spectrum Analysis;Measurement;Measures;Metals;Mission;Mitochondrial Diseases;Modality;Molecular;Molecular Profiling;mouse model;Mus;nanoparticle;National Institute of Allergy and Infectious Disease;National Institute of Biomedical Imaging and Bioengineering;novel;Participant;participant enrollment;particle;Patients;Pattern;Paxlovid;pediatric patients;Peptides;Persons;Pharmaceutical Preparations;Plasma;Potassium;Procedures;Process;Proteins;Protocols documentation;Reaction;Regulation;Research;Research Personnel;Resolution;Retinal Diseases;Role;saliva analysis;saliva sample;Sampling;SARS-CoV-2 antibody;SARS-CoV-2 exposure;seropositive;serosurvey;Serum;Serum Proteins;small molecule;Sodium;Spatial Distribution;Specimen;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;Spectrophotometry;Syndrome;System;Techniques;Time;Tissue imaging;Tissue Sample;Tissue Stains;Tissues;tool;Trace metal;Trauma patient;tumor;ultrasound;uptake;Vaccination;vaccine immunogenicity;vaccine response;Work;Xerostomia

PROJECT_TITLE: Micro Analytical Immunochemistry


NIH_SPENDING_CATS: Bioengineering;Nanotechnology

PI_NAMEs: ZHANG, GUOFENG  (contact)

PROJECT_TERMS: Actins;Autophagocytosis;Biological;Biological Process;Cell Line;Cells;chemical fixation;Collaborations;Cryopreservation;Cytoskeleton;Dehydration;Development;digital;Drosophila genus;Drug Delivery Systems;Electron Microscopy;Exposure to;Freeze Substitution;Freezing;gastrointestinal system;glycosylation;Link;medical schools;Membrane Fusion;Methods;Mitochondria;Molecular;Morphology;Motility;Mucins;nanoparticle;National Heart, Lung, and Blood Institute;National Institute of Biomedical Imaging and Bioengineering;National Institute of Dental and Craniofacial Research;National Institute of Diabetes and Digestive and Kidney Diseases;National Institute of Neurological Disorders and Stroke;Negative Staining;Neurons;neuroprotection;Organelles;Oxidative Stress;pressure;Procedures;Process;Publishing;Research Personnel;sample fixation;Sampling;Stains;Structure;System;Techniques;Transmission Electron Microscopy;United States National Institutes of Health;Universities

PROJECT_TITLE: Electron Microscopy


PI_NAMEs: DIMITRIADIS, EMILIOS K (contact)

PROJECT_TERMS: 3-Dimensional;Address;Adhesions;Affect;Aftercare;Air;Albinism;alpha synuclein;Amino Acid Sequence;Amino Acids;Apoptosis;Appearance;Atomic Force Microscopy;Attention;Automobile Driving;Behavior;Binding Sites;Biochemical;Biogenesis;Biological;biological systems;Biomedical Engineering;Biomedical Research;Blood capillaries;Blood Vessels;Cell membrane;Cell Nucleolus;Cell Nucleus;Cells;Characteristics;Chemicals;Collaborations;Collagen;Communities;Complex;Computer Models;Computing Methodologies;crosslink;Cysteine;Cytoplasmic Granules;Data Analyses;Development;Disease;DNA;Drosophila genus;Elasticity;Electron Microscopy;Environment;Epithelium;eumelanin;Evolution;Exhibits;Exocytosis;experimental study;Extracellular Matrix;Fiber;Fluorescence Microscopy;Gel;Geometry;Goals;Growth;Hair Color;Human;Image;Image Analysis;imaging study;In Vitro;Individual;insight;interest;Intramural Research;Knock-out;Length;mathematical methods;Measures;mechanical properties;Mechanics;Melanins;melanocyte;member;Membrane;Methods;microscopic imaging;Microscopy;Modulus;molecular dynamics;monomer;Monophenol Monooxygenase;Morphology;Mucins;Mucous body substance;mutant;nanofluidic;nanoscale;Nanotopography;National Heart, Lung, and Blood Institute;National Institute of Dental and Craniofacial Research;Neurodegenerative Disorders;novel;novel anticancer drug;Organism;Osmosis;oxidation;Paper;Parkinson Disease;Pathway interactions;Patients;Pattern;Peptides;Pericytes;Periodicity;Pharmaceutical Preparations;Phase;physical science;Physiological;Pigments;Polymers;Positioning Attribute;Probability;Process;Production;Property;protein expression;Protein Glycosylation;Proteins;Protocols documentation;Publishing;Reaction;Recombinants;Research;Resistance;Resolution;Resources;Ribosomes;RNA;Role;Salivary Glands;Sampling;scaffold;Scanning;Scanning Probe Microscopy;single molecule;skin color;small molecule;Spectrum Analysis;Stress;Structure;Supporting Cell;Surface;Swelling;synuclein;System;Techniques;Technology;Temperature;Time;Tissues;tool;Training;Tyrosine;United States National Institutes of Health;Variant;Vesicle;viscoelasticity;Work

PROJECT_TITLE: Scanning Probe Microscopy for the Intramural Research Community


PI_NAMEs: KIESEWETTER, DALE O (contact)

PROJECT_TERMS: Albumins;American;Analytical Chemistry;Animal Model;Animals;Annual Reports;Binding;Biomedical Engineering;cancer therapy;chemical synthesis;Chemicals;Chemistry;Collaborations;Communicable Diseases;Computer software;Consumption;Core Facility;Data;data acquisition;Data Analyses;Data Files;Development;Diagnostic;Diagnostic Imaging;Disease;Employee;Enzymes;Equipment;Evaluation;falls;Fluorine;Goals;High Pressure Liquid Chromatography;Human Resources;Image;Imaging Device;imaging study;imaging system;Immunochemistry;instrument;interest;Intramural Research Program;intravital imaging;invention;Label;Laboratories;Legal patent;Longitudinal Studies;Mass Chromatography;Mass Fragmentography;Mass Spectrum Analysis;meetings;Mentorship;Microscope;Modeling;Molecular;multi-photon;Mus;nanomaterials;National Institute of Biomedical Imaging and Bioengineering;National Institute of Diabetes and Digestive and Kidney Diseases;National Institute of Neurological Disorders and Stroke;Neurosciences Research;NMR Spectroscopy;novel;Oligonucleotides;optical imaging;Organic Chemistry;Peptides;PET/CT scan;physical science;Positron-Emission Tomography;Postdoctoral Fellow;posters;Principal Investigator;Procedures;Process;programs;Prosthesis;protein crosslink;Proteins;Proteomics;Radioactivity;radiochemical;Radioisotopes;Radiolabeled;Radionuclide Imaging;Radionuclide therapy;radiotracer;Reporting;Research;Research Personnel;Resolution;Resource Sharing;Sampling;Scientist;Services;single photon emission computed tomography;small molecule;Societies;System;Therapeutic;Therapeutic Studies;thyroid neoplasm;Time;Tracer;Treatment Efficacy;tumor;validation studies;Water;Work;X-Ray Computed Tomography

PROJECT_TITLE: Molecular Tracer and Imaging Core Facility


NIH_SPENDING_CATS: Assistive Technology;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Biotechnology;Cancer;Clinical Research;Coronaviruses;Coronaviruses Diagnostics and Prognostics;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Eye Disease and Disorders of Vision;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Pediatric;Rehabilitation;Urologic Diseases;Vector-Borne Diseases

PI_NAMEs: POHIDA, THOMAS  (contact)

PROJECT_TERMS: 3-Dimensional;3D Print;adaptive optics;Aedes;Air;Alcohols;analog;analytical ultracentrifugation;Animal Behavior;Animal Feed;Atomic Force Microscopy;Automation;Behavior;Behavior monitoring;Behavioral;Behavioral Assay;bioimaging;Biomechanics;Biophysics;Bioreactors;Biosensor;Blood flow;Blood Vessels;Bone Growth;Brain;brain tissue;Calcium;cancer cell;cancer therapy;Cannulas;Cardiac Electrophysiologic Techniques;Cardiovascular system;Cartilage;Cell Culture Techniques;cell fixing;cell growth;Cell Separation;Cells;Cerebrum;Childhood;Clinic;Clinical;Clinical Research;Collaborations;collaborative environment;Communication;Complex;Computer software;Computers;cost;Coupling;COVID-19 monitoring;COVID-19 patient;COVID-19 test;cranium;crosslink;Culicidae;Custom;data acquisition;data visualization;Dengue Infection;design;Detection;Development;Devices;Diffusion;digital;Disinfectants;Dissection;Documentation;Drosophila genus;drug efficacy;early detection biomarkers;elastography;Electronics;Engineering;engineering design;Epiphysial cartilage;Equipment;Evaluation;Evoked Potentials;Exhibits;exoskeleton;experience;experimental study;Extracellular Matrix;fabrication;Fostering;Freezing;Fresh Tissue;Functional Magnetic Resonance Imaging;Generations;Genomics;Glioblastoma;glymphatic system;Growth;Head;Hela Cells;hemodynamics;Hibernation;high reward;high risk;histological studies;Histology;histone-binding proteins;Histopathology;HIV;Home;Housing;Hydrogels;Image;imager;imaging system;Immunological Models;Impairment;improved;in vivo;Incubated;Incubators;Individual;Infrastructure;Injections;innovation;instrument;instrumentation;Intellectual functioning disability;Intervention;Intramural Research Program;Intubation;Knowledge;Laboratories;Laboratory Research;Larva;Lasers;Learning;Light;Lighting;Liver;Lower Extremity;Macaca;Machine Learning;machine vision;magnetic field;Magnetic Resonance;Magnetic Resonance Elastography;Magnetic Resonance Imaging;Malignant Neoplasms;Maps;Measurement;Mechanics;Memory;Methodology;Methods;Microfluidics;Microscopy;mimetics;mirror neuron;Mobile Health Application;Molds;Monitor;monitoring device;Motor Neurons;Movement;Mus;Myography;Near-Infrared Spectroscopy;neoplastic cell;network dysfunction;Neurodevelopmental Disorder;neuroimaging;neuronal circuitry;Neurosciences;Nociception;novel;novel strategies;open source;Optics;optogenetics;Organ;Organoids;otoacoustic emission;Ovary;Oxygen;Oxygen saturation measurement;Pain;Patients;Pattern;pediatric patients;Perfusion;Peritoneum;PET/CT scan;Phase;Phenotype;Placenta;Polymers;portability;Positron-Emission Tomography;precision medicine;preservation;pressure;Principal Investigator;printed circuit board;Process;Production;Prostate;Prostatic Neoplasms;prosthetic hand;Proteins;Proteomics;prototype;pup;pyrethroid;Quantitative Evaluations;radio frequency;radiological imaging;Reader;recruit;Rehabilitation therapy;Research;research and development;Research Personnel;research study;Resected;resistance mechanism;Resource Sharing;Resources;response;Retinal Dystrophy;retinal imaging;RNA-Protein Interaction;Robotics;Running;Sampling;Science;Scientist;Sensory;Sepharose;serial imaging;Shoes;Signal Transduction;single cell analysis;software development;Software Engineering;Specific qualifier value;spectrograph;Spectrum Analysis;Spermophilus;spheroids;Spinal;Surface;System;Systems Analysis;Systems Biology;systems research;Techniques;Technology;technology development;temporal measurement;Testing;theories;Therapeutic;tick feeding;Time;tissue culture;Tissue Sample;Tissues;Traction Force Microscopy;Training;Transfection;tumor;ultrasound;United States National Institutes of Health;Validation;vapor;vestibular system;Vibrissae;Virus;Vision;Visual;visual tracking;water treatment;wearable device;Zebrafish

PROJECT_TITLE: Instrumentation Development and Engineering Application Solutions (IDEAS) Shared Resource


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

PI_NAMEs: VISHWASRAO, HARSHAD  (contact)

PROJECT_TERMS: 3-Dimensional;American;Artificial Intelligence;artificial intelligence model;Award;base;Bibliography;Biological;Biological Markers;biological systems;Black race;Brain;Canis familiaris;carcinogenesis;Cells;Cellular biology;Child;Collaborations;Comb animal structure;Communities;Complex;computer infrastructure;Computer software;Country;Custom;Data;Data Analyses;Data Scientist;Data Set;design;Development;Doctor of Philosophy;Education;Educational workshop;Emerging Technologies;Engineering;Event;First Independent Research Support and Transition Awards;Fluorescence;Funding;Geometry;High Performance Computing;Home;Human;human data;human disease;Image;Image Analysis;image processing;imaging capabilities;imaging scientist;imaging Segmentation;imaging system;Imaging technology;Immune;Immune system;improved;in vivo;in vivo imaging;innovation;insight;instrumentation;International;Investments;Legal patent;Light;Malignant Neoplasms;Manuscripts;Measurement;Metastatic Osteosarcoma;Methods;Microscope;microscopic imaging;Microscopy;model organism;Molecular;Monitor;multiplexed imaging;Mus;National Center for Advancing Translational Sciences;National Heart, Lung, and Blood Institute;National Institute of Biomedical Imaging and Bioengineering;National Institute of Diabetes and Digestive and Kidney Diseases;National Institute of Neurological Disorders and Stroke;Neoplasm Metastasis;new technology;next generation;novel;operation;optical imaging;Optics;Organoids;Osteosarcoma;Pattern;Preparation;Principal Investigator;Process;prototype;Publishing;Research;research and development;Research Personnel;Resolution;Resource Development;Resource Sharing;Resources;Sampling;Scanning Probe Microscopes;Scientist;second harmonic;Services;Signal Transduction;Societies;software infrastructure;Speed;submicron;Survival Rate;System;Techniques;Technology;terabyte;Testing;theories;Therapeutic;therapeutic candidate;therapy development;Time;Tissue Sample;Tissues;tool;Training;Transgenic Mice;tumor;tumor microenvironment;two-photon;ultra high resolution;Underrepresented Minority;United States National Institutes of Health;user-friendly

PROJECT_TITLE: Advanced Imaging and Microscopy Shared Resource


NIH_SPENDING_CATS: Biotechnology;Eye Disease and Disorders of Vision;Gene Therapy;Genetics;Neurodegenerative;Neurosciences;Rare Diseases

PI_NAMEs: LI, TIANSEN  (contact)

PROJECT_TERMS: adeno-associated viral vector;Animal Model;Biological Models;Books;Capsid;cell type;cesium chloride;Client;Clinical;Collaborations;Complement;CRISPR/Cas technology;Cytomegalovirus;Dependovirus;Disease;DNA Sequence Alteration;efficacy evaluation;Endotoxins;Engineering;Eye diseases;Gene Delivery;Gene Expression;gene therapy;Gene Transduction Agent;Gene Transfer;Genes;Genome;genome editing;GNRH1 gene;Human;human induced pluripotent stem cells;human subject;in vivo;Inherited;Laboratories;Leber's amaurosis;Link;Mediating;Mutation;Names;National Institute of Neurological Disorders and Stroke;Organoids;Pathology;pharmacologic;PHluorin;Plasmid Cloning Vector;Plasmids;Production;promoter;recessive genetic trait;Research;Research Personnel;Research Project Grants;Retina;Retinal Degeneration;Retinitis Pigmentosa;RNA;RPGR gene;Serotyping;Services;Simian virus 40;Techniques;Testing;Therapeutic;therapeutic gene;Tomatoes;United States National Institutes of Health;Usher Syndrome;vector;Viral Packaging

PROJECT_TITLE: Ocular Gene Therapy


NIH_SPENDING_CATS: Bioengineering;Eye Disease and Disorders of Vision;Networking and Information Technology R&D (NITRD)

PI_NAMEs: CASPI, RACHEL R. (contact)

PROJECT_TERMS: 7 year old;Adopted;Age;analytical method;Apoptosis;bioinformatics resource;Blood;Budgets;Cells;Collaborations;Communities;Computer software;cytate;cytokine;data acquisition;Data Analyses;Detection;DNA;Education;Equipment;equipment acquisition;Eye;Flow Cytometry;Foundations;Gene Expression;Genetic Transcription;Genotype;Grant;Hour;Human;human tissue;Individual;Information Technology;instrument;instrumentation;Intramural N.I.H. Research Support;Investments;Laboratories;Leukocytes;Liquid substance;Measurement;Membrane;Methods;Monitor;National Eye Institute;operation;Peripheral Blood Mononuclear Cell;Phenotype;Ploidies;Postdoctoral Fellow;Preparation;Principal Investigator;Procedures;Production;Proliferating;Proteins;Protocols documentation;Publications;Recommendation;recruit;Reporter Genes;Research;Research Personnel;Research Project Grants;Sampling;Science;Services;Sorting;Source;Specimen;square foot;Stains;Students;Techniques;Tissues;Training;United States National Institutes of Health;volunteer;Work

PROJECT_TITLE: Flow Cytometry CORE


NIH_SPENDING_CATS: Biotechnology;Eye Disease and Disorders of Vision;Gene Therapy;Genetics;Neurosciences;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human

PI_NAMEs: DONG, LIJIN  (contact)

PROJECT_TERMS: Alleles;Animal Model;Area;assisted reproduction;Biomedical Research;Biopsy Specimen;Brain;cell type;Cells;Clone Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Complex;Cone;CRISPR/Cas technology;Cryopreservation;Derivation procedure;design;disease model;DNA;Electroporation;Embryo;embryo cryopreservation;embryonic stem cell;Engineering;Etiology;Eye diseases;Female;Fibroblasts;Gene Expression Regulation;Gene Modified;Gene Targeting;Genes;Genetic Engineering;Genetic Induction;Genome;genome editing;Genomic DNA;Genotype;Growth;Guide RNA;Human;human disease;human induced pluripotent stem cells;Human Pathology;induced pluripotent stem cell;inducible Cre;Intramural Research Program;Knock-in;Knock-out;Laboratories;Leber's amaurosis;Mediating;Mission;Mitochondria;molecular pathology;mouse model;Mus;Mutagenesis;mutant;Mutation;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;National Institute of Child Health and Human Development;National Institute of Diabetes and Digestive and Kidney Diseases;National Institute of Neurological Disorders and Stroke;National Institute on Deafness and Other Communication Disorders;Oligonucleotides;operation;Opsin;Ovum;pathogen;Patients;Peripheral Blood Mononuclear Cell;Point Mutation;Population;preimplantation;programs;Proteins;Reaction;Research Personnel;Research Project Grants;Retina;Retinal Degeneration;RNA;Rodent;Role;RPE65 protein;Sampling;Sequence Deletion;Series;Services;sperm cell;Syndrome;System;Tail;Technology;technology development;transcription factor;Transgenes;Transgenic Founder Mouse;United States National Institutes of Health;Usher Syndrome;Viral;Vision;Work

PROJECT_TITLE: NEI Genetic Engineering Core


NIH_SPENDING_CATS: Bioengineering;Eye Disease and Disorders of Vision;Neurosciences

PI_NAMEs: FARISS, ROBERT  (contact)

PROJECT_TERMS: Aging;Agreement;Biological;Cilia;clinical application;Confocal Microscopy;Cryoelectron Microscopy;Crystallization;Custom;Data;denoising;Development;ex vivo imaging;fluorescence imaging;fluorescence lifetime imaging;fluorophore;Freezing;Future;Goals;high resolution imaging;Histology;human model;Image;imaging approach;imaging study;Imaging Techniques;improved;in vivo;insight;instrumentation;Lasers;Methodology;Methylmethacrylate;Microscope;novel;ocular imaging;Organelles;Organoids;Paraffin;particle;Pathologic;Physics;Preparation;Process;protein purification;protein structure;Proteins;Research Personnel;Resolution;Resources;Retina;Retinal Degeneration;Sampling;Scanning;Scientist;Services;Slide;Structure;Structure-Activity Relationship;superresolution imaging;Synapses;Synchrotrons;System;Techniques;Technology;Time;Tissue Sample;tissue/cell culture;Tissues;Training;Transgenic Mice;Transmission Electron Microscopy;United States National Institutes of Health;X ray diffraction analysis;X-Ray Crystallography

PROJECT_TITLE: Imaging Core Unit


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Congenital Structural Anomalies;Eye Disease and Disorders of Vision;Genetic Testing;Genetics;Human Genome;Macular Degeneration;Neurodegenerative;Neurosciences;Pediatric;Peripheral Neuropathy;Precision Medicine;Rare Diseases;Usher Syndrome

PI_NAMEs: GOETZ, KERRY  (contact)

PROJECT_TERMS: achromatopsia;Albinism;American;Aniridia;Anophthalmos;Ataxia;Autosomal Dominant Optic Atrophy;Axenfeld-Rieger syndrome;Biomedical Research;Blood;Blood specimen;Cephalic;Choroideremia;Chronic progressive external ophthalmoplegia;CLIA certified;Clinic;Clinical;Clinical Data;Clinical Research;Clinical Trials;Collaborations;Communities;Community Health;community partnership;cone-rod dystrophy;Consultations;Corneal dystrophy;Data;Data Set;Databases;Deposition;design;Development;diagnosis evaluation;Diagnostic;Disease;DNA;Eligibility Determination;Enrollment;Environment;Epilepsy;Ethics;Extramural Activities;Eye;Eye diseases;Future;Genes;Genetic;Genetic Counseling;genetic information;genetic testing;Genotype;Glaucoma;Goals;Government;Health Personnel;Hermanski-Pudlak Syndrome;Human Genetics;Individual;individual patient;Industry;Informed Consent;interest;Kearns-Sayre syndrome;Leber's Hereditary Optic Neuropathy;Medical Genetics;MELAS Syndrome;Microphthalmos;Mission;Modeling;Molecular;Molecular Diagnostic Testing;molecular diagnostics;Molecular Genetics;molecular phenotype;Neuropathy;news;Night Blindness;Notification;Oculocerebrorenal Syndrome;Online Systems;Pantothenate kinase;Participant;participant enrollment;Pathway interactions;Patients;pattern dystrophies;personalized health care;Persons;Phenotype;phenotypic data;precision medicine;Private Practice;Privatization;Rare Diseases;recruit;Red Fiber;Registries;Reporting;repository;Research;Research Personnel;Research Project Grants;research study;Resources;Retinal Degeneration;Retinal Diseases;Retinal Dystrophy;Retinitis Pigmentosa;Retinoblastoma;Role;Sampling;Scientist;Secure;Seitelberger's Disease;Services;Sorsby's fundus dystrophy;Stargardt's disease;Stickler syndrome;Test Result;tool;treatment trial;United States Dept. of Health and Human Services;United States National Institutes of Health;Usher Syndrome;Vision;Vision research;Vitelliform macular dystrophy;web site;X-Linked Retinoschisis

PROJECT_TITLE: National Ophthalmic Disease Genotyping and Phenotyping Network - eyeGENE


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

PI_NAMEs: QIAN, HAOHUA  (contact)

PROJECT_TERMS: Adopted;Animal Model;automated segmentation;Behavior;behavior test;Collaborations;Communication;Communities;Computer software;Computers;Consultations;Data;Data Analyses;design;Disinfection;Electrophysiology (science);Ensure;Environment;Equipment;experience;Extramural Activities;Eye;Goals;Human Resources;Image;imaging Segmentation;innovation;Instruction;instrument;Machine Learning;Maintenance;Measures;Methods;Monitor;Mus;Performance;Periodicals;Physiology;Procedures;programs;Protocols documentation;Reporting;Research;Research Design;Research Personnel;Research Project Grants;Resources;response;Retina;retinal imaging;Scientist;Services;Supervision;Techniques;tool;Training;United States National Institutes of Health;virtual;Vision;Vision research

PROJECT_TITLE: Visual Function Core


ACTIVITY: ZID

NIH_SPENDING_CATS: Clinical Research;Eye Disease and Disorders of Vision;Health Services;Patient Safety;Rare Diseases

PI_NAMEs: O'DONNELL, WILLIAM  (contact)

PROJECT_TERMS: Age related macular degeneration;Autoimmune;Blood Vessels;Cataract;Clinic;Clinical;clinical application;clinical care;clinical center;Clinical Data;Clinical Informatics;Clinical Investigator;Clinical Protocols;Clinical Research;Clinical Research Protocols;Clinical Trials;Collaborations;Communities;Consult;Consultations;Credentialing;data management;design;Development;diabetic;Diagnosis;Diagnostic;Diagnostic Services;Disease;Education;Ensure;Eye;Eye diseases;Fellowship;Fostering;Funding;Genetic;graft vs host disease;Grant;Health Personnel;high risk;Image;imager;Inflammation;Infrastructure;Inherited;innovation;Institutional Review Boards;Intramural Research Program;Investigation;Laboratory Research;Lasers;Lead;macular edema;Maryland;Metastatic Melanoma;Methodology;Monitor;motor disorder;multidisciplinary;National Eye Institute;National Heart, Lung, and Blood Institute;National Institute of Allergy and Infectious Disease;neovascularization;Neurocysticercosis;Nutritional;off-label drug;Office Management;Ophthalmology;outpatient facility;Pathology;Patient Care;patient safety;Patients;pharmacologic;Phase;Physicians;Prevention;Process;programs;Protocols documentation;quality assurance;Research Personnel;Research Training;Resources;Retinal gene therapy;Safety Management;Services;skills;Source;Students;System;Testing;testing services;Time;Training;Translations;Travel;United States National Institutes of Health;Vision;Visual System;Wegener's Granulomatosis

PROJECT_TITLE: Clinical Research and Protocol Support Services


ACTIVITY: ZIE

NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Congenital Structural Anomalies;Eye Disease and Disorders of Vision;Genetic Testing;Genetics;Neurodegenerative;Neurosciences;Pediatric;Rare Diseases;Usher Syndrome

PI_NAMEs: HURYN, LARYSSA  (contact)

PROJECT_TERMS: achromatopsia;Affect;Albinism;Aniridia;Anophthalmos;Bardet-Biedl Syndrome;Basic Science;Caring;Child;Clinic;Clinical;Clinical Protocols;Clinical Research;Clinical Sciences;Coloboma;Cystinosis;Dark Adaptation;Electrophysiology (science);Environment;Evaluation;experience;Exposure to;Eye;Eye diseases;Family;Fellowship;Generations;Genetic;Genetic Counseling;genetic counselor;Genetic Diseases;genetic pedigree;Grant;Holoprosencephaly;Individual;Inherited;inherited retinal degeneration;interest;Investigation;Journals;Knowledge;Laboratories;Laboratory Research;Learning;Leber's amaurosis;malformation;Manuscripts;Medical;Medical Genetics;Metabolic Diseases;Methods;Microphthalmos;Molecular Diagnosis;molecular diagnostics;Molecular Genetics;multidisciplinary;Neurofibromatosis 2;ophthalmic examination;Ophthalmological Diagnostic Techniques;Patients;Perimetry;Physicians;Preparation;programs;Psychophysics;Publications;Recording of previous events;Research;Research Project Grants;Retinitis Pigmentosa;Review Literature;Series;Stargardt's disease;symposium;Syndrome;Testing;Training;Trichothiodystrophy;Usher Syndrome;Vision;Visual;Work;Writing;WT1 gene;Xeroderma Pigmentosum;Zein

PROJECT_TITLE: Ophthalmic Genetics Fellowship


NIH_SPENDING_CATS: Aging;Clinical Research;Eye Disease and Disorders of Vision;Genetics;Macular Degeneration;Neurodegenerative;Neurosciences;Rare Diseases

PI_NAMEs: KEENAN, TIARNAN  (contact)

PROJECT_TERMS: age related;Age related macular degeneration;biobank;Blood;Clinical;clinical application;clinical care;clinical epidemiology;Clinical Research;clinical training;clinical trial participant;Collaborations;Collection;Dark Adaptation;Diabetic Retinopathy;Disease;DNA;Epidemiology;epidemiology study;experience;Eye diseases;Faculty;Fellowship;follow-up;gene therapy;Genotype;geographic atrophy;high standard;HIV;Hydroxychloroquine;Individual;Inherited;inhibitor;Intervention Studies;macula;Medical;National Cancer Institute;National Eye Institute;National Human Genome Research Institute;Natural History;Nerve Degeneration;neuroprotection;novel;Nursing Faculty;Participant;Patient Care;Patients;Phase;Phenotype;Protocols documentation;recruit;Resources;Retina;Retinal Diseases;retinal toxicity;Retinal Vein Occlusion;screening;Serous;Telangiectasis;Testing;Translational Research;Von Hippel-Lindau Syndrome;X-Linked Retinoschisis

PROJECT_TITLE: Medical Retina Fellowship


ACTIVITY: ZIG

NIH_SPENDING_CATS: Biomedical Imaging;Eye Disease and Disorders of Vision

PI_NAMEs: ALLEN-WORTHINGTON, KRYSTAL  (contact)

PROJECT_TERMS: Accreditation;Administrative Personnel;Anesthesia procedures;Angiography;animal care;Animal Experimentation;animal facility;Animal Husbandry;animal imaging;Animals;Area;Bite;Breeding;Budgets;Callithrix;Caring;Communities;comparative;Contracts;Derivation procedure;Development;Disease;Employee;environmental enrichment for laboratory animals;Euthanasia;Family suidae;Gnotobiotic;Government;Guidelines;Habitats;Healthcare;Hemorrhage;Hour;Housing;Injections;International;Intramural Research Program;Laboratory Animal Science;Laboratory Animals;Laws;Lead;Leadership;Macaca;Magnetic Resonance Imaging;Maryland;Medical;Medicine;Mission;model development;Movement;Mus;National Center for Complementary and Integrative Health;National Heart, Lung, and Blood Institute;National Human Genome Research Institute;National Institute of Allergy and Infectious Disease;National Institute of Child Health and Human Development;National Institute of Mental Health;National Institute of Neurological Disorders and Stroke;National Institute on Alcohol Abuse and Alcoholism;National Institute on Deafness and Other Communication Disorders;nonhuman primate;operation;Operative Surgical Procedures;Participant;pathology imaging;Phenotype;Photography;Play;Policies;policy recommendation;Positioning Attribute;Positron-Emission Tomography;Preparation;Prevention;Principal Investigator;Procedures;programs;Protocols documentation;radiological imaging;Rattus;Regulation;Research;Research Activity;Research Personnel;Research Support;Resources;restraint;Retina;Rodent;Role;Running;sample collection;Services;Specialist;Spermophilus;Techniques;Training;United States National Institutes of Health;Veterinarians;Weaning;Zebrafish

PROJECT_TITLE: Veterinary Research and Resources Section


ACTIVITY: ZIJ

ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: JOHNSON, ANTHONY  (contact)

PROJECT_TERMS: Academy;Acclimatization;African American;American Indians;American Public Health Association;Asian;Award;Awareness;Bangladesh;Behavioral Sciences;Biomedical Research;Caliber;career;Charge;China;Clinical;Collaborations;college;Communication;Communities;community collaboration;community research;community science;Complex;Data;Data Analyses;Dedications;design;Development;Development Plans;disparity reduction;Doctor of Philosophy;Domiciles;Education;Educational Status;Educational workshop;Effectiveness;Ensure;Environment;Epidemiology;epidemiology study;equity, diversity, and inclusion;ethnic diversity;Evaluation;Event;Evidence based practice;experience;Feedback;Fellowship;Female;first responder;Fostering;Funding Opportunities;Gender;Genetic;Genomics;Ghana;Goals;graduate student;Grant;Health;Health behavior and outcomes;Health Disparities Research;health disparity;Health Promotion;high reward;high risk;Hispanic Americans;HIV Vaccine Trials Network;Human;Individual;infrastructure development;insight;Institution;International;Internships;Intervention;Interview;Intramural Research;Intramural Research Program;Knowledge acquisition;Latino;Leadership;leadership development;Learning;lectures;Life;Location;male;Maryland;Medical;Medical Students;meetings;Mentors;Mexican Americans;minority health disparity;Minority Health Research;minority scientist;Minority-Serving Institution;Mission;Monitor;National Institute of Nursing Research;National Institute on Minority Health and Health Disparities;Native Americans;Needs Assessment;Nervous System Disorder;New Zealand;operation;Operations Research;Outcome;outreach;Patient Care;Personal Satisfaction;Persons;Policies;population health;Population Heterogeneity;Population Research;Population Sciences;Postbaccalaureate;Postdoctoral Fellow;posters;practical application;pre-doctoral;Principal Investigator;Problem Solving;Procedures;Professional counselor;Professional Organizations;professional students;Program Development;Program Effectiveness;Program Efficiency;Program Evaluation;programs;Public Health;Readiness;recruit;Recruitment Activity;Reduce health disparities;Research;Research Personnel;Research Training;resource guides;Resources;Role;Science;Science Policy;Scientist;Series;Site;skill acquisition;skills;skills training;Social Behavior;Social Sciences;Societies;Stroke;Student recruitment;Students;success;summer internship;symposium;Training;Training and Education;training opportunity;Training Programs;trend;tribal community;Underrepresented Populations;United States;United States National Institutes of Health;United States Public Health Service;Universities;virtual;Visit;Vocational Guidance;Vulnerable Populations;Water;Work;Writing

PROJECT_TITLE: Intramural Training and Scientific Workforce Outreach Operations


ADMINISTERING_IC: AI

FUNDING_MECHANISM: NON SBIR/STTR CONTRACTS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Prevention

ORG_CITY: SAINT CHARLES

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: EUROFINS PANLABS, INC.

ORG_STATE: MO

PI_NAMEs: ZHAO, YOUNG  (contact)

PROJECT_TERMS: Biological;Biological Assay;Chemistry;Communicable Diseases;Development;Development Plans;Drug Kinetics;Evaluation;In Vitro;in vivo;Interventional Agent Development;Lead;lead optimization;manufacture;pandemic preparedness;pathogen;pre-clinical;product development;programs;Property;Rodent;Safety;screening;Services;Therapeutic;therapeutic development;Toxicology;Toxin;viral pandemic

PROJECT_TITLE: Task E11: Lead Optimization Screening Assays for ADMET, Safety Profiling, and Rodent Pharmacokinetics for the Antiviral Pandemic Preparedness Program (APP)


ADMINISTERING_IC: ES

FUNDING_MECHANISM: INTERAGENCY AGREEMENTS

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Bioengineering;Networking and Information Technology R&D (NITRD);Social Determinants of Health

PI_NAMEs: WALLQVIST, ANDERS  (contact)

PROJECT_TERMS: Acceleration;Accounting;Acute;Address;Adoption;Affect;Agreement;assessment application;Biochemical Pathway;Biological;Biological Models;biological systems;Biology;Cardiovascular system;Chronic;Communication;Computer Models;data modeling;Development;Disease;Environment;environmental chemical;Evaluation;evidence base;Exposure to;genome-wide;hazard;Health;Human;improved;Individual;innovation;Link;mathematical model;Mathematics;Metabolic;Mission;Modeling;Molecular;multi-scale modeling;National Institute of Environmental Health Sciences;Organ;Outcome;Persons;Population;Predisposition;Preventive;reproductive;Research;research and development;response;Rodent;safety assessment;Science;sex;sex as a biological variable;System;tool;tool development;Toxicology;Translating

PROJECT_TITLE: Developing Computational Models to Understand and Predict Adverse Human Health Effects Associated with Exposure to Environmental Chemicals


NIH_SPENDING_CATS: HIV/AIDS;Infectious Diseases;Women's Health Research

ORG_CITY: FREDERICK

ORG_NAME: PRECISION BIOSERVICES, INC.

ORG_STATE: MD

PI_NAMEs: PHIPPARD, DEBORAH  (contact)

PROJECT_TERMS: Autopsy;Biological;Biological Specimen Banks;Biopsy;Body Fluids;cervicovaginal;Clinical Research;Clinical Trials;Cohort Studies;Contracts;Cryopreservation;Dryness;Feces;HIV;HIV Vaccine Trials Network;Institution;International;Laboratories;Lavage;National Institute of Allergy and Infectious Disease;observational cohort study;Paper;Peripheral Blood Mononuclear Cell;Plasma;repository;Saliva;Seminal fluid;Serum;Site;Specimen;Spottings;The Multicenter AIDS Cohort Study;Tissues;Urine;Whole Blood;Women's Interagency HIV Study

PROJECT_TITLE: NIAID Specimen Repository


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Brain Disorders;Cerebrovascular;Chronic Pain;Neurosciences;Pain Research;Stroke

ORG_CITY: ALBANY

ORG_NAME: ALBANY MOLECULAR RESEARCH, INC.

ORG_STATE: NY

PHR: This study is part of the NIH’s Helping to End Addiction Long-term (HEAL) initiative to speed scientific solutions to understand the basis of pain and enhance clinical pain management.

PI_NAMEs: SURMAN, MATTHEW  (contact)

PROJECT_TERMS: absorption;analog;Animal Model;Area;Biological Assay;cancer pain;chemical synthesis;Chemistry;clinical pain;Communication;computational chemistry;Computer Assisted;Contracts;Data;design;Development;direct application;Drug Compounding;drug discovery;Enzymes;Evaluation;Excretory function;Goals;Helping to End Addiction Long-term;In Vitro;indexing;inhibitor;Investigational Drugs;Investigational New Drug Application;Lead;lead optimization;Ligands;Logistics;malignant mouth neoplasm;Metabolic;Metabolism;milligram;Nervous System Disorder;novel;novel therapeutics;Pain;Pain management;Performance;Pharmaceutical Chemistry;Phase;pre-clinical;Preparation;programs;Property;Research Personnel;scaffold;scale up;Services;Shipping;small molecule;Speed;Stroke;Structure-Activity Relationship;Substance Use Disorder;success;System;Teleconferences;Testing;Therapeutic;therapeutically effective;Toxicology;United States National Institutes of Health;Update;Writing

PROJECT_TITLE: SPIGELMAN (UCLA) - MCSP- EXPLORATORY CHEMISTRY (EC)


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Lung Cancer;Networking and Information Technology R&D (NITRD);Prevention;Telehealth;Tobacco;Tobacco Smoke and Health

ORG_CITY: FAIRFAX

ORG_NAME: ICF, INC., LLC

ORG_STATE: VA

PI_NAMEs: SCHWARZ, MARY  (contact)

PROJECT_TERMS: behavioral health;Cancer Control;Contractor;Data;design;Development;Effectiveness;Focus Groups;General Population;Health behavior;Health behavior change;high risk;implementation efforts;interactive tool;Internet;Language;Maintenance;Malignant Neoplasms;Marketing;mHealth;Monitor;Online Systems;programs;Reporting;Resources;Services;Site;smartphone application;smoking cessation;Spanish;Surveys;Text;Tobacco;tool;Underserved Population;Work

PROJECT_TITLE: DEVELOPMENT, MAINTENANCE, AND PROMOTION OF NCI SPONSORED BEHAVIORAL AND MOBILE HEALTH INITIATIVES.


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Services;Mental Health;Mental Illness;Prevention;Suicide;Suicide Prevention

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PI_NAMEs: ROATEN, KIMBERLY  (contact)

PROJECT_TERMS: Health system;Injury;insight;Outcome Assessment;patient screening;screening program;suicidal risk;Suicide;Suicide prevention;suicide rate

PROJECT_TITLE: ASSESSING OUTCOMES OF HEALTH SYSTEM SUICIDE RISK SCREENING PROGRAMS


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Brain Disorders;Cancer;Clinical Research;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Infectious Diseases;Neurosciences

ORG_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

PI_NAMEs: COHEN, JEFFREY  (contact)

PROJECT_TITLE: Pathogenesis and Chemotherapy of Human Virus Infections


NIH_SPENDING_CATS: Clinical Research;Emerging Infectious Diseases;Genetics;Infectious Diseases;Lymphatic Research;Rare Diseases;Vector-Borne Diseases

PI_NAMEs: NUTMAN, THOMAS  (contact)

PROJECT_TERMS: Affect;Allergic;Allergic Disease;Anthelmintics;Antibodies;Antigen-Presenting Cells;Antigens;Automobile Driving;Binding;CD4 Positive T Lymphocytes;Cells;Chronic;Clinical;cohort;Dendritic Cells;Development;Disease;Effector Cell;Enterovirus;Environment;Epitopes;Exhibits;Exposure to;extracellular vesicles;Filarial Elephantiases;Filariasis;Flow Cytometry;FRAP1 gene;Functional disorder;Genetic;Goals;helminth infection;Herpesviridae;Heterogeneity;HHV-6A;Human;human virome;Immune;Immune response;Immunity;Immunoglobulin G;Immunologic Memory;Immunologics;immunoregulation;Individual;Infection;Interleukin-13;Interleukin-4;Interleukin-5;Loa loa;Loiasis;Lymphatic;Memory;MicroRNAs;Molecular;monocyte;multiple omics;Onchocerciasis;Outcome;Parasites;Parasitic infection;Pathogenesis;Pathogenicity;Peptides;Phosphorylation;Production;programs;Proteins;Recording of previous events;Regulation;response;Rhinovirus;RNA;Role;Serology;seropositive;Sorting;Specificity;Strongyloidiasis;T cell response;T-Lymphocyte Subsets;Th2 Cells;transcriptome sequencing;Viral;Viral Antigens;Virus;Work

PROJECT_TITLE: Immunoregulation /Immune Recognition In Filarial/Nonfilarial Parasitic Infection


PI_NAMEs: SHEVACH, ETHAN  (contact)

PROJECT_TERMS: Address;Adult;Alloantigen;allograft rejection;Animals;Antigen Presentation;Antigen Targeting;Antigen-Presenting Cells;Antigens;Area;Autoantigens;Autoimmune;Autoimmune Diseases;Autoimmunity;Avidity;Breeding;Bystander Suppression;CD28 gene;CD44 gene;CD8-Positive T-Lymphocytes;CD80 gene;CD86 gene;CD8B1 gene;Cell surface;cell type;Cells;Clinic;Complex;Dendritic Cells;Development;diphtheria toxin receptor;Disease;Effector Cell;Event;Excision;FOXP3 gene;Germ Cells;Goals;Graft Rejection;graft vs host disease;Homeostasis;Human;IL2RA gene;immune activation;Immune response;Immunologics;Immunosuppression;Immunosuppressive Agents;In Vitro;in vivo;Infection;Inflammatory;Interferon Type II;Interferons;Interleukin-2;Kidney Transplantation;Lymphoid Tissue;Mediating;Modeling;Mus;Organ;partial response;Pathway interactions;Patients;Peptide/MHC Complex;Peptides;Peripheral;Physiologic pulse;Population;prevent;Prevention;promoter;Regulation;Regulatory T-Lymphocyte;response;Role;Signal Transduction;Specificity;Stem cell transplant;Suppressor-Effector T-Lymphocytes;Surface;Synapses;Syndrome;System;T cell response;T memory cell;T-Cell Activation;T-Lymphocyte;Therapeutic;Thymus Gland;Transgenic Mice;tumor;Up-Regulation;uptake

PROJECT_TITLE: Control of Autoimmunity by Regulatory T Cells


NIH_SPENDING_CATS: Brain Disorders;Immunization;Infectious Diseases;Malaria;Rare Diseases;Vaccine Related;Vector-Borne Diseases

PI_NAMEs: MILLER, LOUIS  (contact)

PROJECT_TERMS: African;Aotus primate;Binding Proteins;Blood;blood group;Blood typing procedure;Cerebral Malaria;Complement Receptor;erythrocyte receptor;Erythrocytes;Human;improved;Invaded;Ligands;Malaria;Malawi;Molecular;Parasites;Plasmodium falciparum;Plasmodium vivax;Proteins;Receptor Cell;Role;Saimiri;Testing;vaccine development;Vaccines;Work

PROJECT_TITLE: Malaria Parasite Ligands And Host Cell Receptors


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Genetics;Hematology;Rare Diseases

PI_NAMEs: KOMAROW, HIRSH D (contact)

PROJECT_TERMS: Adult;Age;Alleles;Allergic Disease;anti-IgE;Antibodies;Austria;Autoantibodies;Autoimmune Diseases;Basophils;Binding;Biological Assay;Biological Markers;Biological Products;Blinded;Bone Marrow;Bone Marrow Aspiration;candidate marker;Case/Control Studies;Cell Count;Cell Degranulation;Cell division;Cell Proliferation;Cells;Cellular biology;Characteristics;Child Care;Childhood;China;Clinical;Clinical Immunology;Clinical Trials;cohort;Collaborations;Cutaneous Mastocytosis;Cytometry;Data;Databases;Diagnosis;Disease;Disease stratification;Disseminated eosinophilic collagen disease;eosinophil;Event;Evolution;Exhibits;Fc Receptor;Flow Cytometry;FPR2 gene;France;Future;genetic association;Genetic Polymorphism;Genome;Germany;healthy volunteer;Hematological Disease;Hematopoietic;Heterozygote;Histopathology;Human;Hypersensitivity;Idiopathic anaphylaxis;IL-6 inhibitor;Immunophenotyping;Individual;Indolent Systemic Mastocytosis;Inflammatory;Interferon alpha;Interferon Type I;Interferon-beta;Interferons;Interleukin 6 Receptor;Interleukin-6;Interleukins;Investigation;Israel;Journals;Laboratories;leucyl-phenylalanine;Manuscripts;mast cell;mastocytosis;Measurement;Mediator;Molecular Abnormality;Mutation;novel;novel therapeutics;particle;Pathogenesis;Patients;Pattern;pediatric patients;peripheral blood;Pharmaceutical Preparations;Placebos;Preparation;Prevalence;Production;Proliferating;Publications;Publishing;Quality of life;Randomized;receptor;receptor expression;Recommendation;reduce symptoms;Reporting;Research;response;Retirement;Role;Safety;Sampling;Serum;Severities;Signal Transduction;STAT1 gene;Surrogate Markers;symposium;symptomatology;Symptoms;Systemic Mastocytosis;Training;Tryptase;Tyrosine Kinase Inhibitor;Variant

PROJECT_TITLE: The Pathogenesis, Diagnosis, and Treatment of Systemic Mast Cell Disorders


NIH_SPENDING_CATS: Biotechnology;Genetics;Infectious Diseases;Prevention;Rare Diseases;Vector-Borne Diseases

PI_NAMEs: SACKS, DAVID  (contact)

PROJECT_TERMS: Area;arm;Bilateral;Biological;Biology;biomarker validation;Bite;Blood;Cell fusion;Cell hybridization;Cells;Chromosome Mapping;Clinical;Communities;Competence;Cutaneous Leishmaniasis;Development;Disease;Dose;Drug resistance;Early Diagnosis;Early treatment;Exposure to;fly;Generations;Genes;Genetic;Genetic Recombination;Genetic Transcription;Genome;genome analysis;Geographic Locations;Goals;Haplotypes;HIV;Homologous Protein;Human;Huntingtin-Associated protein 1;Hybrids;Immune response;In Vitro;in vivo;India;Infection;Inflammatory Response;Island;Laboratories;Leg;Leishmania;Leishmania donovani;Leishmaniasis;Life Cycle Stages;Mammals;Mediating;Meiosis;microbiota;Microscopy;Midgut;Modeling;molecular marker;Motility;Mus;novel;Nuclear;paralogous gene;parasite genome;Parasites;Parents;Partner in relationship;pathogen;Pathogenesis;Pathology;Patient Isolation;Patients;Phlebotominae;Phlebotomus;Population;programs;Relapse;Reporting;Saliva;segregation;Series;Sexual Reproduction;single cell analysis;single-cell RNA sequencing;Source;Sri Lanka;Testing;trait;transcriptomics;transmission process;Vaccines;vector;Visceral;Visceral Leishmaniasis;whole genome;Xenodiagnosis

PROJECT_TITLE: Vector Biological  Studies in Leishmaniasis


NIH_SPENDING_CATS: Cancer;Genetics;Infectious Diseases

PI_NAMEs: KOZAK, CHRISTINE  (contact)

PROJECT_TERMS: Adenosine;Alleles;Anti-Retroviral Agents;Anti-viral Response;arms race;Base Pairing;Biology;Breeding;Cell Nucleus;Cell Surface Receptors;Chromosomes;Complementary DNA;Cytidine;Cytidine Deaminase;Data;Deamination;Derivation procedure;Development;Direct Repeats;Disease;DNA;Endogenous Retroviruses;Evolution;Exhibits;Family;Frequencies;Fv-1 protein;gag Gene Products;Gammaretrovirus;Generations;Genes;Genetic;Genetic Polymorphism;Genetic Recombination;Genetic Variation;Genome;genome analysis;genome editing;genome integrity;genome-wide;Geographic Distribution;Geography;Germ Lines;Goals;Guanosine;Haplotypes;HIV;homologous recombination;House mice;Human;Inbred Strain;Inbred Strains Mice;Inbreeding;Individual;Infection;Infection prevention;Inherited;insight;Integration Host Factors;Introns;Laboratory mice;Length;Life Cycle Stages;Long Terminal Repeats;Mammals;mammary tumor virus;mouse genome;Mouse Mammary Tumor Virus;Mouse Strains;Murine leukemia virus;Mus;Mutagenesis;Mutagens;Mutation;novel;Open Reading Frames;Orthologous Gene;pathogen;Pathogenicity;Pattern;Point Mutation;Population;preference;Process;Production;Proviruses;receptor;Recording of previous events;Recurrence;Resistance;resistance factors;resistance gene;Retroviridae;Reverse Transcription;RNA Splicing;Rodent;Role;Sequence Analysis;Site;Source;Southeastern Asia;Specificity;Superantigens;T-Lymphocyte;Time;TRIM5 gene;tumorigenesis;Uracil;usability;Variant;Viral;Viral Genes;viral resistance;Virion;Virus;virus envelope;Virus Replication;Work

PROJECT_TITLE: Genetic Aspects Of Viral Oncogenesis In Inbred Strains and Wild Mouse Species


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases;Orthopoxviruses;Rare Diseases

PI_NAMEs: MOSS, BERNARD  (contact)

PROJECT_TERMS: Biology;Cells;Chimeric Proteins;Data;DNA-Binding Proteins;Drosophila spi protein;Gene Expression;Genome;Goals;Host Defense;membrane assembly;Modeling;Poxviridae;Proteins;prototype;Reagent;Role;tissue culture;Vaccinia virus;Viral;viral DNA;Viral Proteins;Virion

PROJECT_TITLE: Poxvirus Biology


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Immunization;Infectious Diseases;Lung;Pediatric;Pneumonia;Pneumonia and Influenza;Prevention;Vaccine Related

PI_NAMEs: BUCHHOLZ, URSULA  (contact)

PROJECT_TERMS: 2 year old;5 year old;Active immunity;Active Immunization;Acute;Adolescence;Adult;age group;Age Months;Amino Acids;Anti-viral Agents;Antibody Response;Antigens;Apoptosis;Asthma;Attenuated;Attenuated Vaccines;attenuation;Blinded;Cattle;Cessation of life;Child;Childhood;Chimeric Proteins;Clinical;Clinical Research;Clinical Trials;Codon Nucleotides;Collaborations;Complementary DNA;Complication;Conduct Clinical Trials;Cooperative Research and Development Agreement;Data Analyses;Deletion Mutation;design;Development;Dose;effectiveness evaluation;efficacy study;Elements;Evaluation;Experimental Models;follow-up;Genes;Genetic;Genetic Transcription;Genome;Goals;Half-Life;Head;Health;Hemagglutinin;Hospitalization;Human;Human Metapneumovirus;Immune response;Immunity;Immunization;immunogenic;immunogenicity;improved;infancy;Infant;Infection;Interferons;Kansas;Laboratories;Laboratory Study;lead candidate;Lower Respiratory Tract Infection;Manuscripts;Maryland;maternal vaccination;Medical;Missense Mutation;Modeling;Monoclonal Antibodies;mucosal site;Mutation;Neuraminidase;Open Reading Frames;Para-Influenza Virus Type 1;Para-Influenza Virus Type 3;parainfluenza virus;Participant;particle;Passive Immunity;passive immunoprophylaxis;pathogen;Phase;phase 1 study;Phase I Clinical Trials;phase I trial;Phenotype;Pneumovirus;Polymerase;Population;Positioning Attribute;preclinical development;preclinical study;Preparation;Proteins;Publications;randomized placebo controlled study;recombinant virus;Reporting;Research;research clinical testing;respiratory;Respiratory Disease;Respiratory Mucosa;Respiratory syncytial virus;Respiratory Syncytial Virus Infections;Respiratory Syncytial Virus Vaccines;response;reverse genetics;RNA chemical synthesis;RNA replication;Safety;Seasons;seropositive;Serotyping;Side;Subunit Vaccines;System;therapeutic candidate;Toddler;Universities;Up-Regulation;vaccine candidate;Vaccine Clinical Trial;Vaccine Design;vaccine evaluation;vaccine strategy;Vaccines;vector;vector vaccine;Viral;Viral Antigens;Viral Genes;Viral Pathogenesis;viral RNA;virology;Virus;Virus Diseases;volunteer

PROJECT_TITLE: Clinical Trials of  Vaccines for Respiratory Syncytial Virus and Related Viruses


PROJECT_TERMS: A549;Active Immunization;Affect;Age;Animal Experiments;Anti-viral Agents;Antibodies;Antigens;attachment protein G;Attenuated;Attenuated Vaccines;attenuation;Cattle;Cell Culture Techniques;Cells;Child;Childhood;Chimeric Proteins;Clinical Research;Clinical Trials;Code;Codon Nucleotides;Collaborations;Complement;Cooperative Research and Development Agreement;Cytoplasmic Tail;Development;Disease;disulfide bond;Engineering;Epithelium;Genes;Glycoproteins;Growth;Hamsters;Hemagglutinin;Human;Human Parainfluenza Virus 2;Immunization;immunogenic;immunogenicity;immunoprophylaxis;In Vitro;in vivo;Infant;Infection;Interferons;Intranasal Administration;Laboratory Study;Lead;lead candidate;Life;Lung;manufacture;Membrane;Missense Mutation;Modification;Molecular Biology;Molecular Conformation;Molecular Virology;Mutation;Nasal turbinate bone structure;Neuraminidase;neutralizing antibody;NIH Vaccine Research Center;nonhuman primate;Nose;NPM1 gene;Nucleoproteins;Open Reading Frames;Para-Influenza Virus Type 1;Para-Influenza Virus Type 3;parainfluenza virus;particle;Phase;phase 1 study;Phase I Clinical Trials;Phenotype;Phosphoproteins;Pneumovirus;Polymerase;preclinical study;programs;Protein Conformation;Proteins;Reporting;research clinical testing;respiratory;respiratory pathogen;Respiratory syncytial virus;Respiratory Syncytial Virus Vaccines;response;reverse genetics;Serotyping;Serum;Site;System;vaccine candidate;Vaccine Clinical Trial;Vaccines;vector;Vero Cells;Vertebral column;Viral;Viral Antigens;Viral Proteins;Virion;Virus;Virus Replication;Work

PROJECT_TITLE: Laboratory And Pre-clinical Studies Of Parainfluenza Viruses


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Crohn's Disease;Digestive Diseases;Genetics;Inflammatory Bowel Disease;Primary Immunodeficiencies;Rare Diseases

PI_NAMEs: STROBER, WARREN  (contact)

PROJECT_TERMS: Acetylmuramyl-Alanyl-Isoglutamine;Alleles;autosome;Blau syndrome;Cells;Clinical;Colonic inflammation;comparison control;Crohn's disease;Defect;Deubiquitinating Enzyme;Deubiquitination;Development;dextran sulfate sodium induced colitis;Disease;Dominant-Negative Mutation;Etiology;Exhibits;Eye;Functional disorder;Gastrointestinal tract structure;Gene Abnormality;Gene Expression;gene function;Genes;Genetic;Genetic Polymorphism;Genetic Transcription;genome wide association study;gut inflammation;gut microbiota;Heterozygote;Human;IL17 gene;Immunologics;immunoregulation;In Vitro;in vivo;Inflammation;Inflammatory;Inflammatory Bowel Diseases;Innate Immune Response;Interferon alpha;IRF3 gene;IRF4 gene;joint inflammation;Joints;Knock-in;Knock-in Mouse;Lamina Propria;Lead;Learning;lentivirally transduced;Ligands;Link;Lymphoid Cell;Mediating;Mesentery;Molecular;Molecular Abnormality;monocyte;Mus;Mutate;Mutation;NF-kappa B;Organism;overexpression;Patients;peripheral blood;Phosphorylation;Predisposition;Production;Regulation;Reporting;Research;response;RIPK2 gene;sensor;Series;Signal Transduction;Site;Skin;Spleen;Statistical Study;Sterility;Stimulus;T-Lymphocyte;theories;Tissues;TNF receptor-associated factor 3;transcription factor;trinitrobenzene sulfonic acid induced colitis;ubiquitin isopeptidase;Ubiquitination;Ulcerative Colitis;Work

PROJECT_TITLE: Immunoregulatory Defects In Inflammatory Bowel Disease


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emergency Care;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Organ Transplantation;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID;Prevention;Sexually Transmitted Infections;Transplantation

PI_NAMEs: REDD, ANDREW  (contact)

PROJECT_TERMS: Accident and Emergency department;Acquired Immunodeficiency Syndrome;administrative database;Africa;Age;Algorithms;American;Anosmia;Anti-Retroviral Agents;Antibodies;Antibody Response;Asia;Behavioral;Biological;Biological Assay;CD4 Positive T Lymphocytes;Cells;chemokine;Classification;Clinical;Clinical Trials;Clonality;co-infection;cohort;Collaborations;Communicable Diseases;convalescent plasma;Country;COVID-19;COVID-19 impact;cross reactivity;cytokine;Data;Developing Countries;Development;Disease;Disease Progression;Down-Regulation;efficacy evaluation;Emergency Department patient;Epidemiology;Fatigue;Female;Goals;Health;Health Sciences;High Prevalence;HIV;HIV Infections;HIV Seropositivity;HIV-1;HIV/STD;human old age (65+);Immune response;Immunoassay;Immunologics;Immunology;Individual;Infection;Inflammation;Interleukin-6;International;Intervention;Journals;Kidney;Kidney Diseases;Kidney Transplantation;Kinetics;Laboratories;Latin America;Long COVID;longitudinal analysis;low and middle-income countries;Maintenance;male;Male Circumcision;Measures;Mediating;Medicine;men;microbicide;Molecular;Morbidity - disease rate;Mutation;New England;novel;Odds Ratio;organ transplant recipient;Organ Transplantation;Outcome;pandemic disease;Participant;Patient Self-Report;Patients;Perinatal;Persons;Pharmaceutical Preparations;Plasma;Population;post-COVID conditions;pre-pandemic;prevent;Primary Care Physician;programs;Publications;randomized trial;Reporting;reproductive;response;Rest;Role;Sampling;SARS-CoV-2 infection;screening;Serum;sex;sociodemographic variables;Solid;South Africa;superinfection;Symptoms;Syphilis;T cell response;Testing;transcriptomics;transmission process;Transplantation;Uganda;Universities;Vaccination;Vaccines;Validation;Viral;Viral reservoir;virology;Virus Diseases;Virus Latency;whole genome;Woman;Work

PROJECT_TITLE: International Studies of the Acquired Immune Deficiency Syndrome (AIDS)


NIH_SPENDING_CATS: Biotechnology;Genetics;Immunization;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza;Prevention;Vaccine Related

PROJECT_TERMS: Age;Amino Acids;Animal Model;Attenuated;Attenuated Vaccines;attenuation;Basic Science;Biological Assay;Cardiopulmonary;Characteristics;Childhood;clinical candidate;clinical development;Clinical Research;Code;Codon Nucleotides;Computational algorithm;Cooperative Research and Development Agreement;Cytoplasm;design;Development;Elderly;Evaluation;experimental study;Family member;Gene Mutation;Gene Proteins;gene synthesis;Genes;Genetic;Genome;genome-wide;glycoprotein G;Glycoproteins;Goals;Human;Human Metapneumovirus;Hydrophobicity;Immunobiology;immunodeficiency;improved;Individual;Laboratory Study;lead candidate;Licensing;Marketing;member;Messenger RNA;Molecular Biology;Molecular Genetics;Molecular Virology;Morbidity - disease rate;mortality;multiple myeloma M Protein;Murine pneumonia virus;mutant;Mutation;Nonstructural Protein;Nucleoproteins;Open Reading Frames;pathogen;Phase;Phosphoproteins;Play;Pneumovirus;Point Mutation;Polymerase;Population;preclinical development;preclinical study;programs;Proteins;Reagent;Refractory;Reporting;research clinical testing;Respiratory syncytial virus;Respiratory Syncytial Virus Vaccines;Respiratory Tract Diseases;reverse genetics;RNA;RNA Viruses;Rodent;Role;Route;Serology test;System;Temperature;vaccine candidate;Vaccine Clinical Trial;vaccine development;Vaccines;Variant;Viral;viral fitness;Viral Proteins;Virus

PROJECT_TITLE: Laboratory Studies of Human Respiratory Syncytial Virus and Other Pneumoviruses


PI_NAMEs: MARGULIES, DAVID  (contact)

PROJECT_TERMS: Address;Affinity;Antibodies;Antigen-Presenting Cells;Antigens;Area;Autoimmunity;Bacterial Infections;Biochemical;Biological;Cancerous;Cell surface;Cells;Collaborations;Communicable Diseases;Complex;Computational algorithm;Computational Technique;Cryoelectron Microscopy;Docking;Engineering;Epitopes;Family;Generations;genetic analysis;Goals;Histocompatibility;Human;humanized mouse;immune activation;Immune response;Immune system;immune system function;in vitro Model;in vivo;interest;Lymphocyte Function;Malignant Neoplasms;Molecular;Molecular Biology;Molecular Genetics;Monoclonal Antibodies;Monoclonal Antibody Therapy;mouse model;Mus;Myeloid Cells;Natural Killer Cells;Nature;NK Cell Activation;Parasitic infection;Pathologic;Peptide/MHC Complex;Peptides;prediction algorithm;Predisposition;Process;protein complex;Proteins;Publications;Reaction;receptor;Receptor Cell;Recombinants;Regulation;response;Roentgen Rays;Role;Site;Stress;Structure;T-Cell Receptor;three dimensional structure;trafficking;tumor;Viral Physiology;Virus Diseases

PROJECT_TITLE: Molecular Genetic Analysis Of Lymphocyte Function


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Nanotechnology;Orphan Drug;Orthopoxviruses;Prevention;Rare Diseases;Vaccine Related

PROJECT_TERMS: Animal Model;Antibodies;Cellular Immunity;Collaborations;Disease;Encapsulated;Immune response;improved;Infection;Infectious Skin Diseases;Licensing;Lipids;Messenger RNA;Monkeypox;Monkeypox virus;Mucous Membrane;nanoparticle;Orthopoxvirus;particle;Proteins;Recombinant Proteins;recombinant virus vaccine;Research;RNA vaccine;Role;side effect;Testing;vaccine candidate;Vaccines;vector;Viral Antigens;Viral Proteins

PROJECT_TITLE: Recombinant Virus Vaccines


NIH_SPENDING_CATS: Cancer;Hematology;Human Fetal Tissue;Immunization;Infectious Diseases;Neurosciences;Prevention;Vaccine Related

PROJECT_TERMS: afferent nerve;Attenuated;Cells;Chickenpox;Chickenpox Vaccine;Collaborations;Cranial Nerves;Ganglia;Goals;Hematologic Neoplasms;Herpes zoster disease;Herpesvirus Type 3;Human;Immunocompromised Host;Licensing;Molecular Biology;National Heart, Lung, and Blood Institute;Pathogenesis;patient response;Persons;Primary Infection;response;Subunit Vaccines;United States;Vaccines;Virus;Virus Diseases;Zoster Vaccine

PROJECT_TITLE: Molecular Biology Of Varicella Zoster Virus Infection


NIH_SPENDING_CATS: Autoimmune Disease;Digestive Diseases;Genetics;Inflammatory Bowel Disease;Microbiome

PROJECT_TERMS: Affect;Albumins;analog;Animal Experiments;Anti-Inflammatory Agents;Autophagocytosis;Binding;Blood;Caspase;Cell Line;Cell Survival;Cells;Characteristics;Chemicals;Circulation;Colitis;Collaborations;Coupled;Crohn's disease;cytokine;Data;dectin 1;Dendritic Cells;Disease;enhancing factor;Epithelial Cells;Evaluation;Event;Exhibits;Flagellin;Gastrointestinal tract structure;Genes;Genetic;Genetic Polymorphism;Genetic Processes;genome wide association study;gut inflammation;gut microbiome;gut microbiota;Hand;Human;IL18 gene;Immune;immune activation;immune function;Immune response;immunoregulation;Impairment;Individual;Inflammasome;Inflammation;Inflammatory;Inflammatory Bowel Diseases;inhibition of autophagy;inhibitor;Interleukin-10;Intestinal permeability;Intestines;Intraperitoneal Injections;Kidney;kinase inhibitor;knock-down;Lamina Propria;Legionella pneumophila;lethal factor;Ligands;LRRK2 gene;Lung;Macrophage;Measures;Mediating;Medical center;medical schools;Messenger RNA;Methods;microbial;Molecular;Molecular Abnormality;Mucosal Immune Responses;Mus;Needles;New York City;NF-kappa B;Nuclear Translocation;Organism;Parents;Parkinson Disease;Patients;Peripheral;Phosphorylation;Phosphorylation Inhibition;Phosphotransferases;Play;Production;promoter;Property;Proteins;Protocols documentation;Qi;Research Personnel;response;RIPK2 gene;Risk;Role;Series;Serine;side effect;Specificity;Stimulus;Time;Tissues;Toxic effect;transcription factor;Transgenes;Ulcerative Colitis

PROJECT_TITLE: Regulation Of Immune Responses In Humans and in Experimental Animals


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Digestive Diseases;Genetics;Infectious Diseases;Prevention;Rare Diseases;Vector-Borne Diseases

PROJECT_TITLE: Clinical And Therapeutic Studies Of Human Filariasis and Related Diseases


NIH_SPENDING_CATS: Antimicrobial Resistance;Emerging Infectious Diseases;Genetics;Infectious Diseases;Malaria;Orphan Drug;Prevention;Rare Diseases;Vector-Borne Diseases

PI_NAMEs: WELLEMS, THOMAS E (contact)

PROJECT_TERMS: Aedes;Affect;Africa;Aftercare;Anopheles Genus;Anti-malarials;Antimicrobial Resistance;Apoptosis;Area;artesunate;asexual;Attention;biological adaptation to stress;Blood;Blood specimen;Cells;Cellular Stress;Chloroplasts;Collaborations;Communication;Culicidae;Deterioration;Development;Diagnostic Procedure;diagnostic tool;Disease;disease transmission;Drug resistance;Erythrocytes;Eukaryotic Cell;experimental study;Failure;field study;Funding;Genotype;Glutathione;Goals;Hemolysis;Human;Individual;Infection;innovation;insight;Investigation;Knowledge;Label;Laboratories;Light;Malaria;malaria infection;Malaysia;Maryland;Metabolism;Microscopy;Mitochondria;Modeling;Monkeys;Morphology;multidisciplinary;National Institute of Allergy and Infectious Disease;Nature;new therapeutic target;nonhuman primate;novel strategies;Organelles;Oxidative Stress;Parasitemia;Parasites;Pathway interactions;Pharmaceutical Preparations;Pharmacotherapy;Plants;Plasmodium;Plasmodium falciparum;Plasmodium knowlesi;Plasmodium vivax;Plastids;Play;Population;Preparation;Prevention;Primates;Production;Publications;Recrudescences;Recurrence;Regulation;Reporting;Research;Research Project Grants;response;Riboflavin;RNA;Role;Saimiri;Scientific Advances and Accomplishments;Sepsis;Severity of illness;Sex Differentiation;Shapes;Signal Transduction;single cell analysis;single-cell RNA sequencing;sound;Sporozoites;stressor;Swelling;tissue culture;Tissue-Specific Gene Expression;Toxoplasma;transcriptome;transmission process;treatment strategy;ultra high resolution;Universities;vaccine candidate;Vaccines;vector mosquito;Virulence;Work

PROJECT_TITLE: Malaria Drug Resistance and Disease Virulence


NIH_SPENDING_CATS: Biotechnology;Immunization;Immunotherapy;Infectious Diseases;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases

PROJECT_TERMS: Ablation;CCL24 gene;Cells;Cessation of life;chemokine;Chronic;Clinical Research;confocal imaging;Cutaneous;Cutaneous Leishmaniasis;cytokine;Dermis;Development;Discontinuous Capillary;Disease;Environment;eosinophil;experimental study;Generations;Goals;Granuloma;Growth;Hamsters;healing;Hepatic;Heterogeneity;Homeostasis;Human;Immunity;Immunologics;immunoregulation;India;Infection;Infectious Skin Diseases;Inflammatory;Interleukin-4;Interleukin-5;interstitial;Kupffer Cells;Label;Leishmania infantum;Leishmania major;Leishmaniasis;Lesion;Liver;Lymphoid Cell;Macrophage;Mediating;Mediator;migration;Modeling;Molecular;monocyte;mouse model;Mus;Organ;Parasite Control;Parasites;Persons;Preventive vaccine;Property;rational design;recruit;repaired;Resistance;response;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Source;therapeutic vaccine;Tissues;TSLP gene;vaccine development;Vaccines;Visceral;Visceral Leishmaniasis

PROJECT_TITLE: IMMUNE REGULATION AND VACCINE DEVELOPMENT IN LEISHMANIASIS


NIH_SPENDING_CATS: Biotechnology;Digestive Diseases;Genetics;Infectious Diseases;Rare Diseases;Vector-Borne Diseases

PROJECT_TERMS: Angiostrongylus cantonensis;Antigens;Ascaris;Biological Assay;Biological Process;Biology;Cameroon;Chromosomes;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;commercialization;Country;Data;Detection;detection limit;Diagnosis;diagnostic strategy;DNA;Dracunculus medinensis;Fluorescence;fluorophore;Genes;Genome;genome annotation;Genomics;Gnathostoma;Goals;Helminths;IgG4;Immunoassay;improved;Individual;Infection;insight;Intestinal Volvulus;Knowledge;Laboratories;Leishmania;Life Cycle Stages;Loa;Loiasis;Meningitis;Microscope;Molecular;molecular diagnostics;Molecular Target;Monitor;Monoclonal Antibodies;multiplex assay;Nature;neglected tropical diseases;Nematoda;Onchocerciasis;Parasites;parasitism;Pathogenicity;Patients;Plasma;polyclonal antibody;programs;Proteins;Proteomics;Recrudescences;Research Personnel;Sampling;Schistosoma;Schistosoma mansoni;Strongyloides stercoralis;Taenia solium;telomere;Testing;Therapeutic Intervention;tool;Toxocara;Toxocara canis;transmission process;Treatment Efficacy;Trichinella;Trichocephalus trichiura;Update;Validation;Visit

PROJECT_TITLE: Molecular Definition Of Filarial And Related Nonfilarial Genes And Proteins


PI_NAMEs: LONG, ERIC O (contact)

PROJECT_TERMS: Abnormal Cell;Affinity;Alleles;Antigens;Autoimmune Diseases;B lymphoid malignancy;B-Lymphocytes;Binding;Binding Sites;cancer cell;cancer immunotherapy;CD58 gene;CD94 Antigen;Cell Count;Cell Line;Cell surface;Cells;chimeric antigen receptor;Chronic Lymphocytic Leukemia;chronic myeloid leukemia cell;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;CRISPR screen;Cytolysis;Data;Detection;Disease;Down-Regulation;Genes;Genetic study;genome-wide;Germ Lines;glycoproteomics;glycosylation;glycosyltransferase;Golgi Apparatus;HLA-C Antigens;Human;human disease;Immune Evasion;Immune system;Immunoglobulins;Immunotherapy;Infection;K-562;Killer Cells;Knock-out;large cell Diffuse non-Hodgkin's lymphoma;leukemia/lymphoma;Ligands;Lymphocyte Function;Lymphoid Cell;Malignant Neoplasms;Mediating;Modification;MS4A1 gene;Mutation;N-acetyllactosamine;Natural Killer Cells;neoplastic cell;Non-Hodgkin's Lymphoma;Pathway interactions;Patients;Peptide Hydrolases;Peptides;Play;Polysaccharides;predicting response;preference;protein aminoacid sequence;receptor;Receptor Activation;receptor binding;Recombinant Antibody;Regulation;Resistance;response;rituximab;Role;Shapes;Specificity;Surface;Testing;Transferase

PROJECT_TITLE: Regulation of innate lymphocyte function


PI_NAMEs: GERMAIN, RONALD N (contact)

PROJECT_TERMS: adaptive immune response;Adjuvant;Afferent Neurons;Affinity;analytical method;Animals;Anti-CD40;Antigen Presentation;Antigen-Presenting Cells;Antigens;Area;Atlases;autoreactivity;B-Cell Activation;B-Lymphocytes;Behavior;Blood Vessels;Breast;Cancer Model;CD209 gene;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;cell motility;Cell Physiology;cell type;Cells;Cessation of life;checkpoint inhibition;checkpoint therapy;Collection;Color;Communities;complex data;Computer software;Cytometry;Data;Dendritic Cells;Detection;detection method;Development;Dimensions;Disease;Effector Cell;Elements;Endothelial Cells;Event;Excision;Experimental Models;experimental study;Flow Cytometry;Follicular Lymphoma;Freezing;Generations;Germ-Free;Goals;Hand;high dimensionality;Host Defense;Human;Image;imaging modality;imaging study;Imaging technology;Immune;immune checkpoint blockade;Immune response;Immune system;immune system function;Immunohistochemistry;Immunologics;Immunosuppression;Immunotherapeutic agent;Immunotherapy;implantation;improved;in vivo;innate immune function;insight;Interferons;Intervention;Intestines;intravital microscopy;Laboratories;Lectin;Lung;Lung Adenocarcinoma;lymph nodes;Lymphocyte;Lymphocyte Subset;Lymphoid;Lymphoid Tissue;Macrophage;Malignant - descriptor;Malignant neoplasm of ovary;Malignant Neoplasms;Maps;Mediating;Memory;Methods;microbial products;Microscopy;microwave electromagnetic radiation;Modeling;multiplexed imaging;Mus;Mutation;Myelogenous;Myeloid Cells;National Institute of Allergy and Infectious Disease;neoplastic cell;neutrophil;new technology;novel;Oligosaccharides;Ontology;optical imaging;Organ;Outcome;Pancreas;PARP inhibition;Pathology;Patients;Pattern;PD-1 pathway;Pericytes;Phenotype;Photons;Poison;Poisoning;Population;Positioning Attribute;Production;Productivity;programmed cell death protein 1;Proliferating;Property;protein protein interaction;Proteins;Publishing;Regulatory T-Lymphocyte;Reporting;Research;Resolution;responders and non-responders;response;Retina;RNA;Role;Sampling;Signal Transduction;Site;Specific qualifier value;Speed;Spleen;Stains;stem;Structure;Surface Immunoglobulins;System;T-Cell Activation;T-Cell Receptor;T-Lymphocyte;T-Lymphocyte Subsets;technology development;Testing;Thick;Thymus Gland;Tissue imaging;Tissues;TNF gene;transcriptome sequencing;transcriptomics;Transgenic Animals;tumor;Tumor Antigens;tumor growth;tumor immunology;tumor microenvironment;Vagotomy;Variant;Visualization;Work;XCR1 gene

PROJECT_TITLE: Multiscale Analysis of Immune Responses


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Immunization;Infectious Diseases;Prevention;Sexually Transmitted Infections;Vaccine Related;Women's Health Research

PROJECT_TERMS: Acute Disease;Animal Model;Animals;Antibodies;Antibody Response;Cavia;CD8-Positive T-Lymphocytes;clinical center;Disease;DNA;efficacy evaluation;Fibroblasts;genital herpes;genital infection;Goals;Growth;Herpes Simplex Infections;Herpes Simplex Virus Vaccines;HIV;Human;human disease;Human Herpesvirus 2;Immunity;In Vitro;Infection;Lesion;Licensing;Macaca mulatta;Modeling;Monkeys;Monoclonal Antibodies;mortality;Mus;Natural Immunity;Neurologic Symptoms;neutralizing antibody;Phase I Clinical Trials;Prevention;Preventive vaccine;Primary Infection;Primates;Recurrence;Risk;Sapajus apella;Swab;T cell response;Testing;transmission process;United States National Institutes of Health;vaccine candidate;vaccine development;vaccine effectiveness;vaccine-induced antibodies;Vaccines;Vagina;Virus;Virus Shedding;Vulva

PROJECT_TITLE: Development Of Vaccines For Genital Herpes Simplex Infection


NIH_SPENDING_CATS: Atherosclerosis;Autoimmune Disease;Cardiovascular;Clinical Research;Digestive Diseases;Genetics;Inflammatory Bowel Disease;Pediatric;Primary Immunodeficiencies;Rare Diseases

PI_NAMEs: SU, HELEN  (contact)

PROJECT_TERMS: Affect;anergy;Antigens;Apoptosis;Atherosclerosis;Autoimmune Diseases;Autoimmune Process;autoinflammatory diseases;Body System;Cardiomegaly;Cardiovascular system;CD8-Positive T-Lymphocytes;Cell Culture Techniques;Cells;Characteristics;chemokine receptor;Citrobacter rodentium;Colitis;Colon;Complex;congenital immunodeficiency;Data;Development;Disease;disease model;early onset;Endothelial Cells;Epithelium;Event;gastrointestinal;Genes;Goals;GPR15 gene;Guanosine Triphosphate Phosphohydrolases;Homeostasis;Homing;Human;Immune;Immune system;Immune Tolerance;Immunologics;immunoregulation;Inflammatory;Inflammatory Bowel Diseases;intestinal barrier;Investigation;Knockout Mice;Ligands;Lipids;Location;loss of function;Macrophage;Mature T-Lymphocyte;Mediating;Metabolism;Molecular;Morbidity - disease rate;mortality;Mus;Mutation;novel therapeutic intervention;Organ;Pathogenesis;Pathogenicity;Patients;Physiological;Play;Predisposition;prevent;Process;Protein Family;Regulation;Regulatory T-Lymphocyte;Reporting;Research;Role;Signal Pathway;single-cell RNA sequencing;System;T-Lymphocyte;T-Lymphocyte Subsets;targeted treatment;Work

PROJECT_TITLE: Gene Regulatory Events in Establishing Mature T Cell Tolerance


NIH_SPENDING_CATS: Infectious Diseases;Rare Diseases;Sexually Transmitted Infections

PI_NAMEs: HACKSTADT, TED  (contact)

PROJECT_TERMS: Affect;Agriculture;Amino Acids;Apoptotic;Area;Bacteria;Bacterial Proteins;Basic Science;Binding;Blindness;Calcineurin;Calcium;calcium indicator;Calcium Signaling;Cell membrane;Cell Physiology;Cell secretion;Cells;Cellular biology;chemokine;Chlamydia;Chlamydia Infections;Chlamydia trachomatis;Chlamydophila pneumoniae;Chlamydophila psittaci;Cholesterol;Chronic;Chronic Disease;community acquired pneumonia;cytokine;Cytoplasm;Cytosol;Data;Defense Mechanisms;Development;Disease;Domestic Fowls;Down-Regulation;Economics;Ectopic Expression;Endosomes;Environment;Epithelium;Eukaryotic Cell;Event;Face;Genes;Genetic;genetic manipulation;Genetic Transcription;Genome;Golgi Apparatus;Growth;Hela Cells;Homeostasis;Human;human disease;human pathogen;Hydrophobicity;immunological intervention;immunoregulation;Impairment;improved;Industry;Infection;Inflammation;Inguinal lymph node group;inorganic phosphate;Inositol;Integral Membrane Protein;interest;ITPR1 gene;Knock-out;Length;Life Style;Livestock;Lymphogranuloma Venereum;Mass Spectrum Analysis;Mediating;Medical;member;Membrane;Membrane Proteins;Metabolic;Metabolism;Microtubule-Organizing Center;Microtubules;Mitochondria;Mitochondrial Proteins;Modification;Molecular Biology;Mucous Membrane;novel;nuclear factors of activated T-cells;Nutrient;obligate intracellular parasite;Organelles;Parasites;pathogen;Pathogenesis;pathogenic bacteria;Pathway interactions;Pelvic Inflammatory Disease;Probability;Process;Production;Protein Analysis;Protein Biosynthesis;protein protein interaction;Proteins;Proteomics;receptor;recruit;Recycling;Regulation;release of sequestered calcium ion into cytoplasm;response;Serology;Sexually Transmitted Diseases;Signal Pathway;Signal Transduction;Specificity;Sphingomyelins;STIM1 gene;Study Section;Systemic infection;Therapeutic Intervention;Trachoma;trafficking;Transferrin;Translating;Translations;transmission process;Type III Secretion System Pathway;United States;Vacuole;Vesicle;virtual;Zoonoses

PROJECT_TITLE: Cellular Biology Of Host/parasite Interactions


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Brain Disorders;Emerging Infectious Diseases;Infectious Diseases;Neurodegenerative;Neurosciences;Rare Diseases;Transmissible Spongiform Encephalopathy (TSE)

PI_NAMEs: CAUGHEY, BYRON  (contact)

PROJECT_TERMS: Bovine Spongiform Encephalopathy;Characteristics;Chronic Wasting Disease;Clinical;Creutzfeldt-Jakob Syndrome;Detergents;Disease;disease transmission;Goals;in silico;Learning;Lesion;Molecular;molecular dynamics;Neurodegenerative Disorders;neuropathology;Pathogenesis;Pathologic;Prion Diseases;Prions;PrP;Rodent;Scrapie;Structure;Time;transmission process;Work

PROJECT_TITLE: Structures and Activities of Prions and Prion Proteins