ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Climate-Related Exposures and Conditions;Clinical Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Pediatric;Pediatric - AIDS;Prevention;Social Determinants of Health

PHR: Project Narrative This project aims to conduct the first longitudinal convergent mixed-methods study to quantify and elucidate the impact of water insecurity (WI) on HIV related to climate-related drivers, infrastructure challenges, water accessibility, and heightened risk of water-borne diseases, to inform interventions to address WI among people living with HIV (PLWH). We will utilize innovative remote sensing technologies to estimate the effect of climate- related factors on WI and then measure the impact of WI on HIV health outcomes, including viral load suppression and adherence to antiretroviral treatment. Findings from this study will provide initial data on the drivers of and sequelae of WI and their impact on HIV treatment outcomes, to identify and prioritize intervention options to address WI among PLWH.

PI_NAMEs: OUNER, JERRY JOHN (contact)

PROGRAM_OFFICER_NAME: GREENWOOD, GREGORY LOUIS

PROJECT_TERMS: Accounting;Acquired Immunodeficiency Syndrome;Address;Adherence;Affect;Africa;Africa South of the Sahara;AIDS prevention;antiretroviral therapy;Anxiety;Area;barrier to care;Biological Assay;Biological Markers;Blood;burden of illness;Caring;Characteristics;Climate;climate change;climate impact;climate variability;climate-related health;cohort;community advisory board;comorbidity;Coping Skills;Country;Cross-Sectional Studies;Data;Dehydration;Developed Countries;Diarrhea;Disease Progression;Droughts;Education;Educational workshop;efficacious treatment;emotional distress;empowerment;Event;experience;extreme weather;Feedback;Floods;Focus Groups;food insecurity;food preparation;Food production;food security;Fright;Funding;Gender;gender-based violence;Ghana;Global Warming;Health;Healthcare Systems;HIV;HIV Infections;HIV risk;Household;Hygiene;improved;Individual;Infrastructure;innovation;Intervention;intervention mapping;Interview;Kenya;Lead;Life;Literature;Measures;member;Mental Health;Methods;migration;Nausea;novel;Nutritional;Nutritional status;Opportunistic Infections;Outcome;Pathway interactions;Patient Self-Report;Pattern;Persons;physical conditioning;Pilot Projects;point of care;Policies;poor health outcome;Population;Poverty;Precipitation;Prevalence;Prevention Research;Productivity;programs;protective factors;Rain;remote sensing;Risk;Role;Safety;Sanitation;Scanning;sea level rise;Seasons;sensor technology;side effect;social health determinants;social stigma;sociodemographics;socioeconomics;Structure;Surveys;Technology;Tenofovir;theories;therapy development;Time;Treatment outcome;treatment research;United States National Institutes of Health;Urine;Venous;Viral;Viral Load result;Visit;Vomiting;Water;waterborne illness;weather patterns;Woman

PROJECT_TITLE: Identifying the mechanisms of water insecurity on HIV treatment outcomes

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


ADMINISTERING_IC: ES

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Genetics

ORG_CITY: PITTSBURGH

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PHARMACOLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Telomere maintenance is essential for genome stability and the prevention of cancer and degenerative diseases. The proposed research will examine how environmental genotoxic and oxidative stress cause accelerated telomere shortening, and the pathways that preserve damaged telomeres. This project will reveal how various forms of telomeric DNA damage impact telomere function, cellular function and organism health.

PI_NAMEs: OPRESKO, PATRICIA L (contact)

PROGRAM_OFFICER_NAME: HEACOCK, MICHELLE

PROJECT_TERMS: Acceleration;Animal Model;Award;base;cancer cell;cancer prevention;carcinogenesis;Cell Culture Techniques;Cell Physiology;Cell Proliferation;cell type;Cells;Chromosomes;Chronic;Degenerative Disorder;DNA Damage;DNA lesion;Environment;Excision Repair;experimental study;flexibility;Functional disorder;Funding;Generations;Genetic;Genome Stability;Genotoxic Stress;Goals;Guanine;Health;Human;human tissue;innovation;Knowledge;Learning;Lesion;Maintenance;Measures;model organism;Mus;National Institute of Environmental Health Sciences;nucleobase;Organ;Organism;Outcome;Oxidative Stress;Pathway interactions;Phase;Phenotype;Population;preservation;programs;Proliferating;Proteins;repaired;Research;System;Technology;telomere;telomere damage;telomere loss;Telomere Maintenance;Telomere Shortening;tool;Transgenic Organisms;Translating;Work;Zebrafish

PROJECT_TITLE: Excision Repair of Environmental Telomere Damage


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: HIV/AIDS

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PI_NAMEs: YUKL, STEVEN A (contact)

PROGRAM_OFFICER_NAME: NOVAK, LEIA KAYE


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: OKLAHOMA CITY

ORG_NAME: OKLAHOMA MEDICAL RESEARCH FOUNDATION

ORG_STATE: OK

PHR: Project Narrative  Autoimmune diseases cause a large social burden on both the patients afflicted with the disease and their support systems. The Accelerated Medicine Partnerships in Autoimmune and Immune-Mediated Diseases (AMP AIM) is a consortium of Governmental, University, Biotech, and Non-profit institutions that will work to assemble an unparalleled repository of samples and data from biopsy tissues using advanced technologies and analysis approaches of samples from four autoimmune diseases: System Lupus Erythematosus (or “Lupus”), Rheumatoid Arthritis (RA), Sjogren’s Syndrome (SjD), and Psoriatic Spectrum of Disease (Psoriasis, PsD). The Oklahoma Medical Research Foundation’s Tissue Research Core (OMRF TRC) proposes to provide the Network with 1) standard methods, 2) centralized sample storage/management, 3) centralized testing, 4) collection of tissue pathology data, and 5) data systems to organize all data through its existing staff and infrastructure.

PI_NAMEs: GUTHRIDGE, JOEL MARVIN (contact);JAMES, JUDITH A

PROGRAM_OFFICER_NAME: WANG, YAN Z

PROJECT_TERMS: Acceleration;adjudication;Attention;Autoimmune;Autoimmune Diseases;Awareness;biobank;Biological Markers;Biopsy;Biotechnology;Caring;Cells;Certification;Characteristics;Cladribine;Clinical;clinical application;clinically actionable;cohort;Collection;cost effective;Country;Data;Data Protection;Data Set;Database Management Systems;Dedications;design;digital imaging;digital pathology;Disease;distributed data;Emerging Technologies;Ensure;Equipment and supply inventories;experience;Foundations;Genetic;high dimensionality;Histology;Image;Immune;Immune System Diseases;improved;Industry Standard;Information Systems;Infrastructure;innovation;Institution;Institutional Review Boards;interest;International;Investments;Knowledge;Leadership;Location;Logistics;Lupus;Lupus Erythematosus;Manuals;Measurement;Mediating;Medical Research;Medicine;Methods;migration;Mission;Modality;Molecular;Molecular Profiling;Monitor;Multiomic Data;multiple omics;Oklahoma;Pathology;Patients;Phenotype;phenotypic biomarker;Play;Positioning Attribute;Procedures;Process;programs;Protocols documentation;Psoriasis;Quality Control;Recording of previous events;repository;Research;Rheumatoid Arthritis;Sampling;Science;Secure;Services;Shipping;single cell analysis;Site;Sjogren's Syndrome;social;Solid;Space Perception;Staff Development;Standardization;success;Support System;System;Systemic Lupus Erythematosus;Technology;Testing;Tissue Banks;Tissue imaging;Tissue Sample;Tissues;Training;transcriptomics;Universities;Work

PROJECT_TITLE: Accelerating Medicines Partnership-Autoimmune and Immunologic Disease Tissue Research Core


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Assistive Technology;Behavioral and Social Science;Bioengineering;Clinical Research;Disability Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Physical Injury - Accidents and Adverse Effects;Physical Rehabilitation;Rehabilitation;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_CITY: CHICAGO

ORG_NAME: REHABILITATION INSTITUTE OF CHICAGO D/B/A SHIRLEY RYAN ABILITYLAB

ORG_STATE: IL

PHR: Frequently the more severe a person's motor impairment, the less able they are to operate the very assistive machines, like powered wheelchairs and robotic arms, which might enhance their quality of life. The purpose of the proposed study is to provide people with tetraplegia with the means, through non-invasive technologies, to control robotic arms with their available body mobility, while concurrently promoting the exercise of available body motions and the maintenance of physical health. We propose and study an approach that leverages robot machine learning and autonomy in order to facilitate human motor learning of how to operate a robotic arm using a customized interface, in order to make powered assisted manipulation more accessible to people with severe paralysis. 1

PI_NAMEs: ARGALL, BRENNA  (contact)

PROGRAM_OFFICER_NAME: BITTMANN, MORIA FISHER

PROJECT_TERMS: 3-Dimensional;Activities of Daily Living;Address;Affect;Algorithms;arm;assistive robot;Back;body-machine interface;brain machine interface;Caregivers;Cerebral Palsy;Chronic;Complex;Computers;Data;Development;Devices;Dimensions;Eating;Effectiveness;efficacy evaluation;empowerment;Environment;Exercise;feeding;Formulation;Fostering;Freedom;Future;Goals;Hand;Head;Health Benefit;high dimensionality;Human;improved;invention;Learning;Left;Limb structure;Machine Learning;machine learning algorithm;Maintenance;Maps;Mental Depression;Mental Health;Motion;Motivation;Motor;motor impairment;motor learning;motor recovery;Motor Skills;Movement;Multiple Sclerosis;n-dimensional;Neurologic;novel strategies;Paralysed;Patients;Performance;Persons;physical conditioning;Population;Posture;Powered wheelchair;Procedures;Process;psychologic;Quadriplegia;Quality of life;Rehabilitation therapy;Residual state;Robot;robot control;Robotics;Self-Help Devices;sensor;Shoulder;Side;Signal Transduction;skills;Specific qualifier value;Spinal cord injured survivor;Stroke;System;Technology;technology platform;Testing;Time;two-dimensional;Wheelchairs;Work

PROJECT_TITLE: Human and Machine Learning for Customized Control of Assistive Robots

STUDY_SECTION: BNVT

STUDY_SECTION_NAME: Bioengineering of Neuroscience, Vision and Low Vision Technologies Study Section[BNVT]


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

NIH_SPENDING_CATS: Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human

ORG_CITY: ROCHESTER

ORG_DEPT: ORTHOPEDICS

ORG_NAME: UNIVERSITY OF ROCHESTER

ORG_STATE: NY

PI_NAMEs: NICHOLS, ANNE E.C. (contact)

PROGRAM_OFFICER_NAME: MARQUITZ, ARON

PROJECT_TERMS: Acute;Affect;Atlases;Award;Biological Products;Biology;Biomechanics;bone;Bone remodeling;cell behavior;cell type;Cells;Communication;Data;design;experimental study;Genetic;Genetic Markers;GLAST Protein;Goals;Growth;healing;Health;Homeostasis;improved;Injury;interest;Knowledge;mechanical load;Mechanics;Modeling;Molecular;Morphology;mouse model;Mus;Musculoskeletal;novel;osteoblast differentiation;Osteoblasts;Osteocytes;Pathway interactions;Periosteum;Phase;physiologic model;Physiological;Play;Population;postnatal;Process;progenitor;Property;Research;response;Role;Running;scleraxis;Signal Transduction;single-cell RNA sequencing;Source;spatial integration;stem cells;tendon development;Tendon structure;Testing;Tissues;tool;transcription factor;transcriptomics;Update;Work

PROJECT_TITLE: Epitenon-derived progenitor cells in tendon healing and adaptation

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Nutrition;Pediatric;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: MINNEAPOLIS

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE This longitudinal observational study examines multiple levels of Structural Racism and Discrimination (SRD) including individual (both intrapersonal and interpersonal), neighborhood, institutional, and societal/policy and their associations with mental, physical, and behavioral health outcomes across the life course. Innovative mixed-methods (e.g., ecological momentary assessment, geographic information system data, community- based participatory approaches, biomarkers) are being used at two sites (Minnesota, Georgia), across two time points 18 months apart, with families from racially/ethnically and socioeconomically diverse households (n=927). Study findings will identify targets for intervening at multiple SRD levels to promote health equity.

PI_NAMEs: BERGE, JERICA M;FERTIG, ANGELA RICE (contact)

PROGRAM_OFFICER_NAME: MUDD, LANAY MARIE

PROJECT_TERMS: Adolescence;Adult;Affect;African American;anxiety symptoms;behavioral health;Biological;Biological Markers;Black race;Blood Pressure;Body mass index;C-reactive protein;Cardiometabolic Disease;cardiometabolic risk;cardiometabolism;career;career development;Child;Childhood;Clinical Trials;Communities;community based participatory approach;cytokine;Data;depressive symptoms;design;Diet;Dietary intake;Discrimination;Ecological momentary assessment;Elements;ethnic diversity;Ethnic Origin;Event;Exposure to;Family;Geographic Information Systems;Geographic Locations;Glycosylated hemoglobin A;Health;health disparity;health equity;health equity promotion;Heart Rate;Hemoglobin C;High Density Lipoprotein Cholesterol;Hispanic;Household;Housing;Immigrant;Individual;innovation;Institution;Institutional Racism;Intervention;killings;Life Cycle Stages;Lipids;Longitudinal cohort study;Longitudinal Studies;Longitudinal, observational study;Measures;Mental Depression;Mental Health;Methods;Minnesota;Moods;multidisciplinary;Native Americans;negative mood;Neighborhoods;Outcome;Outcome Measure;Parents;Participant;perceived discrimination;perceived stress;Persons;Physical activity;physical conditioning;Police;Policies;Prevalence;prospective;Psyche structure;Public Assistance;Public Health;Race;racial diversity;racism;Refugees;Reporting;Research;Research Design;Research Personnel;Risk Factors;Rural;rural families;rural setting;Safety;Sampling;Schools;sedentary lifestyle;segregation;Site;socioeconomics;Source;Stress;Structural Racism;Surveys;therapy development;Time;Triglycerides;Unhealthy Diet;United States;urban setting;Voting;waist circumference;Well in self;Work

PROJECT_TITLE: Research Supplements to Promote Diversity in Health-Related Research (Admin Supp Clinical Trial Not Allowed)


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Clinical Research;Digestive Diseases;Endocrine Disruptors;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hepatitis;Hepatitis - B;Infectious Diseases;Liver Cancer;Liver Disease;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative This cohort consortium project provides the first comprehensive evaluation of exposure to per- and polyfluoroalkyl substances (PFAS) with risk of liver cancer overall, by racial/ethnic groups, and by hepatitis B virus (HBV) and C virus infection (HCV) status. This research will generate new insights into the etiology of liver cancer and advance the field of liver cancer prevention and health disparities, thereby ultimately reducing morbidity and mortality from this deadly disease. Findings on PFAS and health effects will also provide novel information for regulatory agencies, policymakers, and practitioners to make science-based decisions and action plans to improve public health.

PI_NAMEs: ZHANG, XUEHONG  (contact)

PROGRAM_OFFICER_NAME: DELLAVALLE, CURT TAVIS

PROJECT_TERMS: Address;African American population;Age;Area;Biological Assay;Cancer Burden;Cancer Etiology;cancer health disparity;cancer risk;cancer subtypes;carcinogenicity;Cessation of life;Chemicals;Chronic Hepatitis B;cohort;Cohort Studies;Collection;Communities;Data;design;Diabetes Mellitus;diabetes risk;Diagnosis;Disease;Disparity;Environmental Pollutants;ethnic diversity;Ethnic Origin;Ethnic Population;Etiology;Evaluation;experience;exposed human population;Exposure to;Follow-Up Studies;Goals;Health;health disparity;Health Professional;Heavy Drinking;Hepatitis B Virus;Hepatitis C;Hepatocarcinogenesis;high risk;Hispanic Community Health Study/Study of Latinos;Hispanic Populations;Human;improved;Incidence;innovation;insight;Intervention;Investigation;Laboratories;Laboratory Animals;Liver;liver cancer prevention;Longitudinal cohort study;Malignant neoplasm of liver;Malignant Neoplasms;manufacture;Measures;men's group;Metabolic Diseases;Methods;Morbidity - disease rate;mortality;Nested Case-Control Study;Not Hispanic or Latino;novel;Nurses' Health Study;Obesity;Occupational;Occupational Exposure;Orthohepadnavirus;Patients;Pattern;perfluorooctane sulfonate;perfluorooctanoic acid;Plasma;Policy Maker;Poly-fluoroalkyl substances;Population;Population Heterogeneity;Prevention;Prevention strategy;prospective;Prospective, cohort study;Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial;Public Health;Race;racial diversity;racial population;Regulation;Reproducibility;Research;Resources;Risk;Risk Factors;Role;Sample Size;Sampling;Sampling Studies;Science;sex;Smoking;Solid;Source;stem;Technology;Tissues;United States;Viral;Virus;Virus Diseases;Weight Gain;Women's Health;Work

PROJECT_TITLE: Perfluoroalkyl Substances (PFASs) and Liver Cancer Risk in the United States

STUDY_SECTION: CHSA

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology A Study Section[CHSA]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Services;Neurodegenerative;Neurosciences

ORG_CITY: COLUMBIA

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

ORG_STATE: MO

PHR: PROJECT NARRATIVE In this project we examine how interdisciplinary communication using text messaging can improve delivery of age-friendly care to nursing home (NH) residents and prevent avoidable NH-to-hospital transfer. This study will provide information needed for the development and testing of interventions using convenient, low-cost technologies, like text messaging, to ultimately reduce morbidity and mortality in residents with Alzheimer’s disease or a related dementia.

PI_NAMEs: POWELL, KIMBERLY RYAN (contact)

PROGRAM_OFFICER_NAME: KELLER, CHANDRA

PROJECT_TERMS: Acute;Address;Age;Alzheimer's disease related dementia;Caring;Categories;Characteristics;Clinical;Communication;Communication Methods;Complex;cost;Cost Control;Data;data exchange;Data Set;Data Sources;Decision Making;Dementia;Development;Documentation;Electronics;Elements;Emotional;Emotional Stress;evidence base;Expenditure;Flare;Friends;Goals;Health;Health system;high risk;Home Nursing Care;Hospitalization;Hospitals;Impaired cognition;improved;Individual;Interdisciplinary Communication;Intervention;Language;Medical Care Team;Medicare/Medicaid;member;Modernization;Morbidity - disease rate;mortality;Names;Natural Language Processing;novel;Nursing Homes;older adult;Ontology;Outcome;Pathway Analysis;Patients;Pattern;Pharmaceutical Preparations;Population;portability;prevent;Preventive care;Process;Property;Quality of Care;Resource-limited setting;satisfaction;Severities;Social Network;Standardization;Stress;Structure;Symptoms;Technology;Telefacsimile;Telephone;Test Result;Testing;Text Messaging;therapy development;Thinking;Time;transmission process;Update;Visiting Nurse;Vocabulary;Vulnerable Populations;Work

PROJECT_TITLE: Reducing Avoidable Nursing Home-to-Hospital Transfers of Residents with ADRD: An Analysis of Interdisciplinary Team Communication using Text Messages

STUDY_SECTION: ICSC

STUDY_SECTION_NAME: Interdisciplinary Clinical Care in Specialty Care Settings Study Section[ICSC]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_DEPT: OTOLARYNGOLOGY

PHR: PROJECT NARRATIVE Black women in the United States have worse outcomes and higher mortality from breast and uterine cancer than any other racial/ethnic group. The UPMC Hillman Cancer Center has assembled a multidisciplinary team with expertise in cancer health disparities, epidemiology, environmental health, and basic science to conduct a preliminary evaluation of whether environmental and social determinants of health modify risk of chemical beauty products in the development of breast and uterine cancer among Black women.

PI_NAMEs: FERRIS, ROBERT L. (contact)

PROGRAM_OFFICER_NAME: ROBERSON, SONYA

PROJECT_TERMS: Administrative Supplement;Basic Science;Beauty;Biological;Biological Factors;black women;Cancer Center;Cancer Center Support Grant;Cancer Control;cancer health disparity;cancer risk;Chemicals;Communities;community engagement;Community Outreach;Data;Development;Disparity;Endocrine Disruptors;environmental justice;Environmental Risk Factor;Environmental Science;Epidemiology;Ethnic Population;Evaluation;Exposure to;Genetic;Goals;Hair;Health Sciences;interest;Intervention;Life Cycle Stages;Malignant Breast Neoplasm;Malignant neoplasm of cervix uteri;Malignant Neoplasms;mortality;multidisciplinary;Outcome;racial population;Research;response;Risk;Risk Reduction;social factors;social health determinants;United States;Uterine Cancer

PROJECT_TITLE: Exploration of Contemporary Modifiable Exposures and Cancer in Beauty Salons

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_NAME: HARRY S. TRUMAN MEMORIAL VA HOSPITAL

PHR: Heart failure is the number reason for admission among patients in the Veteran (VA) health system without cure, consuming a significant portion of VA medical resources. This proposal is to test a hypothesis that targeting UCH-L1, a deubiquitinating enzyme, is a novel approach for the treatment of heart failure and circulating UCH-L1 serves as novel biomarker of heart failure. The outcome will pave the way for translational studies of targeting UCH-L1 to treat and manage cardiac disease and heart failure.

PI_NAMEs: CUI, TAIXING  (contact)

PROJECT_TERMS: Admission activity;Animal Model;Automobile Driving;Autophagocytosis;Biological Markers;Cardiac;Cardiac Myocytes;Cardiomyopathies;Cessation of life;Circulation;Clinical;Complex;Consumption;Deubiquitinating Enzyme;diagnostic value;exosome;Failure;FRAP1 gene;Functional disorder;Genes;Genetic;Geometry;Health system;Heart;Heart Diseases;Heart failure;Hsc70 protein;Human;Hydrolase;improved;in vivo;inhibition of autophagy;inhibitor;Knock-out;Link;Mediating;Mediator;Medical;Medical Research;Membrane Proteins;Mission;Molecular;mouse model;Mus;myocardial damage;novel;novel diagnostics;novel marker;novel strategies;novel therapeutics;Outcome;overexpression;Pathogenicity;Pathologic;Pathology;Pathway interactions;patient population;Patients;pharmacologic;Phenotype;Phosphorylation;Phosphotransferases;Physiological;Pilot Projects;pressure;prognostic value;programs;Proteasome Inhibition;Protein Dephosphorylation;Proteins;Regulation;Research;Resources;Risk Factors;Risk Reduction;Role;Signal Transduction;Sirolimus;Site;Symptoms;Testing;Therapeutic;Time;Transgenic Organisms;translational study;Ubiquitin;ubiquitin isopeptidase;Up-Regulation;Veterans;Wild Type Mouse

PROJECT_TITLE: To explore the potential of UCH-L1 as a novel therapeutic and diagnostic target in heart failure


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Chronic Liver Disease and Cirrhosis;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Hepatitis;Liver Disease;Substance Misuse

ORG_CITY: DALLAS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: Project Narrative: Alcohol-associated liver disease (ALD) is a leading cause of mortality/morbidity, and there is no FDA-approved therapy for any stage of ALD. Unfortunately, patients with ALD rarely have their underlying alcohol use disorder (AUD) concomitantly addressed. This consortium links health care providers with expertise in AUD and ALD in a unified treatment strategy to evaluate novel combined treatments for AUD/ALD in patients with advanced ALD. The existing resources of the NIAAA-funded AlcHepNet are used for patient studies, biospecimen collection and site-specific translational studies.

PI_NAMEs: BROWN, E SHERWOOD ;MITCHELL, MACK CLARENCE (contact)

PROGRAM_OFFICER_NAME: GAO, PETER

PROJECT_TERMS: acamprosate;Address;Adrenal Cortex Hormones;Affect;alcohol abstinence;alcohol abuse therapy;Alcohol consumption;alcohol misuse;alcohol use disorder;Alcoholic Hepatitis;Alcoholic Liver Diseases;Alcohols;anakinra;Ancillary Study;antagonist;Antimicrobial Effect;Antioxidants;Apoptotic;Behavior Therapy;Behavioral;behavioral study;Biological Specimen Banks;care outcomes;Caregivers;catalyst;Chimeric Proteins;Cirrhosis;Clinical;clinical center;Clinical Data;Clinical Treatment;Clinical Trials;cohort;Collaborations;Collection;Combined Modality Therapy;Compensation;Computers;Data;data repository;Databases;Diagnosis;Double-Blind Method;drinking;Early Intervention;Eligibility Determination;Evaluation;evidence base;FDA approved;Funding;Glucocorticoids;group counseling;Guidelines;Health Personnel;healthy volunteer;Heavy Drinking;Hospitals;improved;Individual;Informatics;Interleukin-1 Receptors;interleukin-22;Knowledge;Lactobacillus casei rhamnosus;Link;Liver;Liver diseases;longitudinal database;Masks;Measures;meetings;Morbidity - disease rate;mortality;National Institute on Alcohol Abuse and Alcoholism;new therapeutic target;novel;novel therapeutics;Observational Study;open label;optimal treatments;Outcome;patient population;Patient Preferences;patient registry;Patient-Focused Outcomes;Patients;Pattern;Pharmacotherapy;Phase;Phosphatidylethanolamine;Physicians;placebo controlled trial;Placebos;Prednisone;primary endpoint;prospective;Quality of Care;Quality of life;Randomized;randomized placebo controlled trial;Randomized, Controlled Trials;Regression Analysis;Reporting;Research Design;Research Personnel;Resource Allocation;Resources;Safety;Site;social stigma;standard of care;Steroids;Systems Biology;Testing;Thinking;Translational Research;translational study;Transplantation;treatment strategy;Zinc

PROJECT_TITLE: Integrated therapies for alcohol use and ALD (ITAALD) Network – UTSW Clinical Center

STUDY_SECTION_NAME: Special Emphasis Panel[ZAA1 DD (05)]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Bioengineering;Clinical Research;Diabetes;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: Columbus

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE No changes from parent grant. See Supplement Research Plan for supplement specific information.

PI_NAMEs: ROBERTS, CYNTHIA J (contact)

PROGRAM_OFFICER_NAME: MCKIE, GEORGE ANN

PROJECT_TERMS: Age;Biological Markers;biomechanical test;Biomechanics;Clinical;Clinical Data;Clinical Management;cohort;Cornea;crosslink;Data;Diabetes Mellitus;diabetic;Diabetic Retinopathy;Disease;Disease Progression;Evaluation;Eye;Eye diseases;follow-up;Foundations;Funding;Glaucoma;Glycosylated hemoglobin A;Goals;Grant;Hyperglycemia;hypertension treatment;instrument;Keratoconus;Knowledge;Longitudinal Studies;Measures;Modeling;novel;Ocular Hypertension;Ocular Pathology;Ohio;Outcome;Panthera leo;parent grant;Pathologic;Performance;Pharmaceutical Preparations;Primary Open Angle Glaucoma;Procedures;Process;Protocols documentation;Research;response;Retinal Diseases;Risk;Risk Factors;Sclera;Spottings;Stress;Synthetic Prostaglandins;Thick;Time;translational potential;Translations;Validation;Visit

PROJECT_TITLE: Corneal Biomechanics in Ocular Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(81)-S]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Chronic Pain;Drug Abuse (NIDA only);Neurosciences;Opioid Misuse and Addiction;Opioids;Pain Research;Substance Misuse

ORG_CITY: AMHERST

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

PHR: Project Narrative The proposed research is relevant to public health because opioid use is prevalent in the United States and the human and financial costs associated with tolerance and withdrawal are at crisis levels. The relationship between altered adenylyl cyclase signaling and potassium channels present an opportunity to develop intriguing candidates target to prevent opioid-induced tolerance and withdrawal. This proposal is relevant to the part of NIDA’s mission that pertains to conducting basic research on drug use, its consequences, and the underlying neurobiological mechanisms involved in long-term use.

PI_NAMEs: KLEIN, AMANDA HELEN (contact)

PROGRAM_OFFICER_NAME: HILLERY, PAUL

PROJECT_TERMS: Absence of pain sensation;Acute;Address;Adenoviruses;Adenylate Cyclase;adenylyl cyclase 1;Affect;Agonist;Analgesics;antagonist;ATP sensitive potassium channel complex;Attenuated;base;Basic Science;Cells;Central Nervous System;Chronic;Chronic inflammatory pain;chronic pain relief;Classification;Clinical;combat;Coupled;Cyclic AMP;Cyclic AMP-Dependent Protein Kinases;Data;Development;Down-Regulation;drug development;Drug Targeting;Drug usage;Electrophysiology (science);Exposure to;Financial cost;Future;G-Protein-Coupled Receptors;genetic approach;genetic predictors;Goals;GTP-Binding Proteins;Human;Hypersensitivity;Hypertrophy;improved;In Situ Hybridization;In Vitro;in vitro activity;in vitro Assay;in vivo;Incidence;innovation;Intervention;Intrathecal Injections;knock-down;Knowledge;Mechanics;Mediator;Mission;Molecular;Morphine;mu opioid receptors;Mus;National Institute of Drug Abuse;Nerve Fibers;Nervous System;Neural Conduction;neurobiological mechanism;neuronal excitability;Neurons;neurophysiology;Nociceptors;novel;novel therapeutics;opiate tolerance;Opioid;opioid abuse;Opioid agonist;opioid exposure;opioid misuse;opioid use;opioid withdrawal;Outcome;pain patient;pain processing;pain signal;Patients;Peripheral Nervous System;pharmacologic;Play;Potassium;Potassium Channel;prescription opioid;prevent;Protein Isoforms;Public Health;Recording of previous events;Research;response;Rodent Model;sciatic nerve;Signal Transduction;Signal Transduction Pathway;Spinal Cord;Spinal Ganglia;spontaneous pain;Therapeutic;United States;Up-Regulation;Viral Vector;Withdrawal;Withdrawal Symptom;Work

PROJECT_TITLE: KATP Channels as Downstream targets of adenylyl cyclases during opioid tolerance and withdrawal

STUDY_SECTION: NPI

STUDY_SECTION_NAME: Neurobiology of Pain and Itch Study Section [NPI]


NIH_SPENDING_CATS: Assistive Technology;Behavioral and Social Science;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Eye Disease and Disorders of Vision;Health Services;Networking and Information Technology R&D (NITRD);Patient Safety;Rehabilitation;Social Determinants of Health;Telehealth

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Narrative This NIH Diversity Supplement will provide a clinical research experience with related training for the candidate with a doctorate in occupational therapy to become involved in the funded non-inferiority trial (BeST-AID) of telerehabilitation versus in-office care for low vision magnification devices. Specifically, we will evaluate how enhanced intervention approaches (habit training and motivational interviewing administered by the candidate) in both telerehabilitation and in-office settings impact BeST-AID participants’ acceptability and increased utilization of visual aids. Additionally, we aim to develop, implement and evaluate a training protocol specifically for visually impaired patients to improve their ability to independently access electronic health records and healthcare resources through Epic patient portals at ophthalmologic academic centers.

PI_NAMEs: BITTNER, AVA K (contact)

PROGRAM_OFFICER_NAME: WIGGS, CHERI

PROJECT_TERMS: acceptability and feasibility;Activities of Daily Living;Address;Blindness;Bluetooth;Caring;clinical care;clinical encounter;clinical practice;Clinical Research;Clinical Trials;Collaborations;Consult;Data;Devices;Disparity;effective intervention;efficacy evaluation;electronic health information;Electronic Health Record;electronic health record system;evidence base;experience;Face;Family member;Feedback;Frequencies;functional health literacy;Funding;Future;Geography;Goals;Grant;Habits;Health;health care availability;health literacy;health management;Health system;Healthcare;Home;Hospitals;Improve Access;improved;Individual;Institution;Intervention;Lead;Leadership;mobile application;Modality;motivational enhancement therapy;Occupational Therapist;Occupational Therapy;Online Systems;Outcome;Participant;patient portal;Patient Self-Report;Patients;Population;Protocols documentation;Provider;Proxy;Quality of life;Reading;reading ability;Recommendation;rehabilitation service;remote delivery;Research;Resources;Role;sensor;Services;social engagement;sociodemographics;Standardization;Technology;telehealth;telerehabilitation;Time;Training;Training Support;Transportation;treatment as usual;United States National Institutes of Health;Videoconferencing;Vision;vision aid;vision rehabilitation;Visual;Visual Aid;Visual impairment;web app;Work

PROJECT_TITLE: Beacon Sensors and Telerehabilitation to Assess and Improve use of Devices (BeST-AID) for Low Vision


NIH_SPENDING_CATS: Clinical Research;Genetics;Pediatric;Primary Immunodeficiencies;Rare Diseases

ORG_CITY: NEW YORK

ORG_DEPT: PEDIATRICS

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative Persistent inflammation is a venomous biological process - it can initiate or worsen human pathologies of all organ systems. The purpose of this study is to delineate the mechanisms behind rare monogenic causes of inflammatory syndromes featured around the JAK-STAT pathway. Improved understanding of innate immune regulation in these patients will ultimately inform the design of anti-inflammatory therapeutics.

PI_NAMEs: BOGUNOVIC, DUSAN  (contact)

PROGRAM_OFFICER_NAME: MORRIS FEARS, MARGARET A

PROJECT_TERMS: Affect;Alleles;Anti-Inflammatory Agents;Apoptosis;Arthritis;Atopic Dermatitis;autoinflammation;autoinflammatory;autoinflammatory diseases;Autophagocytosis;Biochemical;Biological Assay;Biological Process;Body System;Cell Line;cell type;Child;Clinical;clinically significant;Complex;congenital immunodeficiency;cytokine;Cytokine Signaling;Data;Dermatitis;design;Development;Disease;dominant genetic mutation;early onset;Ectopic Expression;Enteritis;Evaluation;exome sequencing;Family;Functional disorder;gain of function mutation;gastrointestinal;Gastrointestinal tract structure;gene function;gene product;Genes;Genetic Predisposition to Disease;Genetic Variation;Goals;Health;Hereditary Disease;Human;human disease;Human Pathology;IL6ST gene;Immune;Immune system;Immune System Diseases;Immunologic Receptors;Immunologics;immunoregulation;Impairment;improved;In Vitro;in vivo;Individual;Inflammation;Inflammatory;innate immune function;insight;Intellectual impairment;Interferon Type I;Interferons;Interleukin-10;Interleukin-6;IRF3 gene;ISG15 gene;JAK1 gene;Knowledge;Laboratories;Lesion;loss of function mutation;Mediating;Medicine;member;Membranous Glomerulonephritis;Methods;Molecular;Mutation;Natural Immunity;Neurologic;novel;Outcome;pathogen;Pathogenesis;Pathway interactions;Patients;Phenocopy;Phenotype;Phosphorylation;Play;Point Mutation;Predisposition;Production;protein function;recruit;Regulation;Reporting;response;RIPK1 gene;Role;Series;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Skin;STAT2 gene;Syndrome;TBK1 gene;Technology;Therapeutic;TLR3 gene;TNF gene;Transactivation;transmission process;type I interferon receptor;Type I Interferonopathy;Up-Regulation;Viral;Virus Diseases;white matter

PROJECT_TITLE: Inborn Errors of Immunity Leading to Autoinflammatory Syndromes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IMM-K(52)]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Biotechnology;Genetics;Immunization;Infectious Diseases;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention;Sexually Transmitted Infections;Vaccine Related

ORG_CITY: OAK PARK

ORG_NAME: THYREOS, INC

PHR: PROJECT NARRATIVE HSV-2 is a sexually-transmitted infectious (STI) agent that is responsible for painful genetical blisters in approximately 15% of the population: 40-80 million people globally are estimated to suffer from recurrent symptomatic genital infections. The virus can be transmitted to neonates during birth where encephalitis can result in long-term neurologic deficits and disseminated infections are life threatening. The goal of these studies is to develop an HSV-2 non-neuroinvasive live-attenuated vaccine based on our established R2 technology. The vaccine will be tested for safety, immunogenicity, and efficacy in preparation for clinical trials.

PI_NAMEs: SMITH, GREGORY ALLAN (contact)

PROGRAM_OFFICER_NAME: CONNOLLY, KRISTIE LEE

PROJECT_TERMS: Ablation;adaptive immune response;Animal Model;Antibodies;antibody-dependent cell cytotoxicity;antibody-dependent cellular phagocytosis;Attenuated;Attenuated Vaccines;attenuation;Award;Axonal Transport;Bacterial Artificial Chromosomes;Binding;Birth;Bulla;Cavia;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cell Culture Techniques;Central Nervous System Diseases;Clinical;Clinical Trials;Code;Congenital herpes simplex;cytokine;Dedications;design;Development;Disease;Encephalitis;Excision;Failure;Foundations;Fred Hutchinson Cancer Research Center;Gene Expression;Genes;Genetic;Genetic Recombination;genital infection;Genitalia;Goals;guinea pig model;Herpes Simplex Virus Vaccines;Herpesvirus 1;Human Herpesvirus 2;Immune response;immunogenicity;Infection;Infectious Agent;Invaded;latent infection;Life;Marker Vaccines;Marketing;Measures;Medical center;Messenger RNA;Methods;Modeling;Monitor;mouse model;Mucous Membrane;Mus;mutant;Mutate;Mutation;neonate;Nervous System;Neurologic;Neurologic Deficit;neutralizing antibody;Newborn Infant;next generation;Pain;Pediatric Hospitals;Persons;Phase;Phase I Clinical Trials;Phenotype;Population;Positioning Attribute;pre-clinical;Preparation;product development;Proteins;prototype;Recombinants;Recurrence;research and development;Safety;safety testing;Serial Passage;Serology;Sexual Transmission;Sexually Transmitted Diseases;Side;Small Business Technology Transfer Research;Stains;T cell response;Technology;technology platform;Testing;Tissues;transmission process;Universities;vaccine candidate;Vaccine Design;vaccine development;vaccine efficacy;Vaccines;Vagina;Validation;Vertical Disease Transmission;Virulence;Virus;Virus Replication;Work

PROJECT_TITLE: An R2 non-neuroinvasive herpes simplex virus type 2 vaccine

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DCAI-U(11)]


ADMINISTERING_IC: DC

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Clinical Research;Cost Effectiveness Research;Health Services;Prevention

ORG_CITY: IOWA CITY

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Project Narrative The lifetime prevalence of voice problems in teachers is considerably higher (in some reports as high as 94%) than in the average occupation and negatively impacts children's learning in the classroom. The current research provides further insight into how internal and external risk factors (including classroom vocal demands) are associated with the vocal accommodations that teachers make. Additionally, this research investigates the economic impact of current and potential policies (or lack thereof) used to address voice problems and/or improve vocal health.

PI_NAMEs: HUNTER, ERIC J (contact)

PROGRAM_OFFICER_NAME: KOPF, LISA MARIE

PROJECT_TERMS: Acoustics;Address;Administrator;Advocate;Affect;Attitude;Behavioral;Characteristics;Child;Clinical;Clinical assessments;Clinical Data;Clinical Trials;clinically significant;Communication;communication theory;Complex;cost;Cost Analysis;cost effective;Data;Development;economic impact;Economics;Education;educational atmosphere;Educational process of instructing;Engineering;Environment;experience;Face;Financial cost;Focus Groups;Goals;Health;Health education;Health Personnel;Health Policy;High Prevalence;Human Resources;improved;Individual;innovation;insight;Interdisciplinary Study;Intervention;Interview;Knowledge;large datasets;Learning;Length;Measures;Methodology;Occupational;Occupational Health;Occupations;Outcome;Pattern;Physiological;Policies;Policy Maker;Predictive Factor;present value;preservation;Prevalence;Preventive;preventive intervention;Principal Investigator;Productivity;Public Health;Recovery;Registries;Rehabilitation therapy;Reporting;Research;Research Personnel;Resources;response;Risk;Risk Factors;risk mitigation;Sampling;School Teachers;Schools;Science;Selection Bias;simulation;stem;Stroboscopy;Surveys;System;teacher;Technology;Testing;Time;tool;Translating;treatment program;virtual reality;virtual reality environment;Voice;Work

PROJECT_TITLE: Protecting Teachers’ Voices: Investigating Risk Factors, Conducting Cost Analysis

STUDY_SECTION: MFSR

STUDY_SECTION_NAME: Motor Function, Speech and Rehabilitation Study Section[MFSR]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Digestive Diseases;Orphan Drug;Pancreatic Cancer;Precision Medicine;Rare Diseases

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: PROJECT NARRATIVE: Pancreatic ductal adenocarcinoma (PDA) is a deadly cancer, and there is an urgent need for rapid treatment response monitoring so that patients can be spared the significant toxicities of ineffective drugs and can instead be offered alternative regimens with a higher chance of efficacy. In this project, we will combine circulating tumor DNA and metabolic imaging to improve the timely assessment of the clinical utility of therapies in PDA, with the overarching goal of lengthening survival in PDA patients.

PI_NAMEs: COLLISSON, ERIC  (contact);GOENKA, AJIT HARISHKUMAR;WANG, ZHEN JANE

PROGRAM_OFFICER_NAME: LIN, CHARLES

PROJECT_TERMS: adjudication;Biological Markers;Biology;biomarker discovery;burden of illness;CA-19-9 Antigen;Cancer Etiology;Cessation of life;chemotherapy;Clinical;Clinical Management;cost;Data;data integration;data modeling;Detection;Diagnosis;Disease;Drops;effective therapy;evidence base;Excision;fluorodeoxyglucose;fluorodeoxyglucose positron emission tomography;Futility;Future;genomic biomarker;Goals;Grant;Hybrids;Image;image reconstruction;improved;improved outcome;ineffective therapies;innovation;KRAS2 gene;liquid biopsy;Localized Disease;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Malignant neoplasm of pancreas;Malignant Neoplasms;Medical Oncologist;Metabolic;metabolic imaging;Minority;Modeling;Molecular;Monitor;mutant;Neoadjuvant Therapy;Neoplasm Metastasis;next generation;Operative Surgical Procedures;Pancreatic Ductal Adenocarcinoma;Pathologic;Patient-Focused Outcomes;Patients;personalized decision;Pharmaceutical Preparations;Positioning Attribute;Positron-Emission Tomography;precision medicine;Prediction of Response to Therapy;prospective;radiologist;Recurrence;Regimen;Resectable;Resistance;response;response biomarker;Staging;standard of care;Surgeon;Surgical Models;Systemic Therapy;Testing;Therapeutic;tool;Toxic effect;treatment optimization;treatment response;tumor DNA;Tumor Markers;United States;Unresectable;X-Ray Computed Tomography

PROJECT_TITLE: Optimizing Pancreatic Cancer Management with Next Generation Imaging and Liquid Biopsy

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: Project Narrative The goal of the Center for Innovative NeuroTech Advancement (CINTA) is to rapidly transform emerging technologies into commercially viable, clinically focused solutions for disorders of the nervous system as a hub under the NIH Blueprint MedTech: Incubator Hubs program. CINTA will support the advancement of neurotechnology solutions by adapting and improving upon the proven model that CIMIT developed and implemented for RADx Tech to accelerate promising neurotechnologies that address critical areas of unmet needs in the diagnosis and treatment of nervous system disorders to human-grade prototypes. CINTA plans to find, fund, facilitate, and accelerate 15 projects per year through this program.

PI_NAMEs: BONATO, PAOLO ;SCHACHTER, STEVEN C. (contact)

PROGRAM_OFFICER_NAME: WOLFSON, MICHAEL

PROJECT_TERMS: Acceleration;Address;Area;Clinical;Collaborations;commercialization;Committee Members;Communities;Companions;Complex;Development;Diagnosis;Emerging Technologies;Ensure;Environment;equity, diversity, and inclusion;Evaluation;experience;Funding;Goals;Health Technology;Healthcare;Human;improved;Incubators;Infrastructure;innovation;Institution;interest;International;Investments;Laboratories;Leadership;manufacture;Medical;Medicine;Modeling;multidisciplinary;Needs Assessment;Nervous System Disorder;neurological rehabilitation;neurotechnology;Outcome;outreach;Performance;Process;programs;prototype;RADx Tech;Research;Research Personnel;Resources;Risk;Science;sharing platform;success;technological innovation;Technology;tool development;Training;Translational Research;United States National Institutes of Health;virtual technology;web site

PROJECT_TITLE: Center for Innovative NeuroTech Advancement - CINTA


NIH_SPENDING_CATS: Bioengineering;Eye Disease and Disorders of Vision

PI_NAMEs: SCHACHTER, STEVEN C. (contact)

PROJECT_TERMS: Acceleration;Achievement;Address;Area;Benchmarking;career;Charge;Clinical;Committee Membership;Communities;Companions;Conflict of Interest;Data Security;Diagnosis;Elements;equity, diversity, and inclusion;experience;Feedback;Funding;Glean;Guidelines;Healthcare;Human;improved;Infrastructure;innovation;interest;Investments;Leadership;Life Experience;Modeling;Needs Assessment;neighborhood disadvantage;Nervous System Disorder;Neurology;neurotechnology;Online Systems;operation;outreach;Patient advocacy;patient oriented;Patients;Point of Care Technology;Policies;Primary Care;Process;programs;prototype;RADx Tech;Recommendation;Research;Resources;Role;Secure;Structure;Technology;Time;tool development;Translations;United States National Institutes of Health;Voice;Work

PROJECT_TITLE: Center for Innovative NeuroTech Advancement (CINTA) - Administrative Core


FUNDING_MECHANISM: NON SBIR/STTR CONTRACTS

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology

ORG_CITY: BOULDER

ORG_NAME: BOLDER BIOTECHNOLOGY, INC.

ORG_STATE: CO

PI_NAMEs: COX, GEORGE  (contact)

PROJECT_TERMS: Acute;Advanced Development;analog;Animals;Biotechnology;Blood specimen;clinical trial protocol;Development;Dose;Enzyme-Linked Immunosorbent Assay;Formulation;GMP lots;Hematopoietic;Histopathology;Human;human subject;Interleukin-11;Investigational Drugs;Investigational New Drug Application;manufacture;Measures;medical countermeasure;Mus;Phase I Clinical Trials;Plasma;protocol development;Protocols documentation;Qualifying;Radiation;Radiation exposure;Radiation Toxicity;Reference Standards;Reporting;Research Contracts;Safety;Sampling;stability testing;Statistical Data Interpretation;Testing;Time;Tissues;Toxicokinetics;Toxicology;United States Food and Drug Administration;Work;Writing

PROJECT_TITLE: ADVANCED DEVELOPMENT OF BBT-059 AS A RADIATION MEDICAL COUNTERMEASURE FOR DOSING UP TO 48H POST EXPOSURE"


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Infectious Diseases;Vector-Borne Diseases

ORG_CITY: DOYLESTOWN

ORG_NAME: BARUCH S. BLUMBERG INSTITUTE

PI_NAMEs: CHANG, JINHONG  (contact)

PROJECT_TERMS: Advanced Development;antiviral drug development;candidate selection;Chemistry;Clinical assessments;efficacy evaluation;lead optimization;manufacture;pandemic disease;pre-clinical;product development;programs;research and development;Research Support;safety assessment;Therapeutic;therapeutic candidate;therapeutic development;Viral;Virus;Yellow fever virus;Yellow Fever Virus Infection

PROJECT_TITLE: Development of an Antiviral for Yellow Fever Virus Infection


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Genetics;Hematology;Human Genome;Precision Medicine

ORG_CITY: ROCKVILLE

ORG_NAME: WESTAT, INC.

ORG_STATE: MD

PI_NAMEs: SHIFFLETT, PATRICIA  (contact)

PROJECT_TERMS: Clinical Research;Cohort Studies;Communication;Data;genome resource;genome sequencing;Goals;Heart Diseases;Hematological Disease;improved;Individual;Knowledge;Lung Diseases;Maintenance;Manuals;metabolome;methylome;multiple omics;National Heart, Lung, and Blood Institute;operation;Phenotype;precision medicine;programs;Proteome;Publications;Research Personnel;Sleep Disorders;Trans-Omics for Precision Medicine;transcriptome sequencing;website development;whole genome;working group

PROJECT_TITLE: NHLBI TRANS-OMICS FOR PRECISION MEDICINE (TOPMED) ADMINISTRATIVE COORDINATING CENTER (ACC)


NIH_SPENDING_CATS: Bioengineering

ORG_CITY: RESEARCH TRIANGLE PARK

ORG_NAME: RESEARCH TRIANGLE INSTITUTE

ORG_STATE: NC

PI_NAMEs: SEVERYNSE-STEVENS, DIANA  (contact)

PROJECT_TERMS: Clinical Research;commercialization;Data;Decision Making;Development;Development Plans;Disease;Documentation;Education;falls;first-in-human;Funding;Health Services Accessibility;Individual;Institution;Intellectual Property;Investments;Leadership;Legal patent;Licensing;Mediation;meetings;member;Monitor;National Heart, Lung, and Blood Institute;new technology;pre-Investigational New Drug meeting;preclinical development;Principal Investigator;programs;Property Rights;Public Health;Recommendation;Research;Research Contracts;Research Personnel;Resources;Rights;Risk Assessment;Risk Management;Services;success;Technology;technology development;Time;translational pipeline;Variant

PROJECT_TITLE: NHLBI CATALYZE COORDINATING CENTER SUPPORT SERVICES


NIH_SPENDING_CATS: Burden of Illness;Cancer;Prevention;Social Determinants of Health

ORG_NAME: MASSACHUSETTS STATE DEPT OF PUB HEALTH

PI_NAMEs: GERSHMAN, SUSAN  (contact)

PROJECT_TERMS: Annual Reports;anti-cancer research;Cancer Control;Cancer Patient;cancer statistics;Data;Diagnosis;Disease;Geography;Incidence;Infrastructure;insight;Malignant Neoplasms;Monitor;National Cancer Institute;Patients;Population;Prevalence;SEER Program;Social Characteristics;Subgroup;Time;treatment pattern;trend

PROJECT_TITLE: SEER - Core Infrastructure


NIH_SPENDING_CATS: Antimicrobial Resistance;Infectious Diseases;Malaria;Orphan Drug;Rare Diseases;Vector-Borne Diseases

ORG_CITY: ORLANDO

ORG_NAME: UNIVERSITY OF CENTRAL FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE Malaria is one of the major global health problems afflicting about 229 million people and causing over 400,000 deaths annually. Because of the emergence of drug resistance parasites, current therapies for malaria are rapidly losing their efficacy. The proposed research seeks to identify novel antimalarial lead compounds targeting parasite protein kinases effective against multidrug resistant malaria with therapeutic and prophylactic properties, thus contributing to the global malaria elimination campaign.

PI_NAMEs: CHAKRABARTI, DEBOPAM  (contact);GRAY, NATHANAEL SCHIANDER;WINZELER, ELIZABETH A

PROGRAM_OFFICER_NAME: MO, ANNIE X  Y

PROJECT_TERMS: Address;Affect;Africa;Aminopyridines;analog;Animal Model;Anti-Infective Agents;Anti-malarials;Appearance;Artemisinins;asexual;Binding Sites;Biochemical;Biological;Biological Assay;Biology;Blood;California;cancer therapy;Cellular biology;Cessation of life;Chemicals;Child;Collaborations;Collection;Combined Modality Therapy;Copy Number Polymorphism;Cyclic AMP-Dependent Protein Kinases;design;Development;Dose;drug development;Drug Industry;Drug resistance;efficacy evaluation;Erythrocytes;Evaluation;Evolution;Exhibits;Falciparum Malaria;FDA approved;Florida;genome sequencing;global health;Goals;human disease;humanized mouse;Hydrophobicity;improved;In Vitro;in vivo;Infection;inhibitor;inhibitor therapy;Interdisciplinary Study;kinase inhibitor;knock-down;Knowledge;Laboratories;Lead;Lipids;Liver;Malaria;Methods;Modeling;Molecular;Molecular Conformation;Molecular Target;mouse model;Multi-Drug Resistance;Mus;nanomolar;next generation;novel;Oncogenic;optimism;Parasite resistance;Parasites;Persons;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacologic;pharmacophore;Phenotype;phosphoproteomics;Phosphorylation;Phosphotransferases;Plasmodium;Plasmodium falciparum;Plasmodium falciparum genome;Plasmodium vivax;Population;Predisposition;Property;prophylactic;Prophylactic treatment;Protein Kinase;protein kinase inhibitor;Proteins;pyridine;Relapse;Reporting;Research;Resistance;Resistance profile;resistant strain;Resources;Route;scaffold;screening;Signal Pathway;small molecule therapeutics;Source;Southeastern Asia;targeted treatment;Testing;Therapeutic;Thiophenes;Universities;Validation;whole genome

PROJECT_TITLE: Plasmodium Protein Kinase Focused Antimalarials Discovery

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AIDC-V(02)]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Assistive Technology;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Hearing Loss;Neurosciences

ORG_CITY: COLLEGE PARK

ORG_DEPT: BIOLOGY

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

PHR: PROJECT NARRATIVE Practice-based improvements in our ability to detect or discriminate subtle sound features – a process known as perceptual learning – is important for the development of speech and language, and for maximizing the benefits of hearing aids and cochlear implants. While non-sensory factors, such as attentional state or delivery of reward, are known to shape perceptual learning, we lack a comprehensive understanding of the neural mechanisms involved. The experiments proposed here will address this issue by assessing the contribution of one non-sensory brain region, the orbitofrontal cortex, and its descending projection to the auditory cortex to perceptual learning.

PI_NAMEs: CARAS, MELISSA LYNNE (contact)

PROGRAM_OFFICER_NAME: POREMBA, AMY

PROJECT_TERMS: Anesthesia procedures;Animal Testing;Animals;Arousal;Attention;Auditory;Auditory area;Auditory system;autism spectrum disorder;Behavioral;Brain;Brain region;Calcium;calcium indicator;Clinical;Cochlear Implants;Cues;Data;design;Detection;Devices;Dyslexia;Electrodes;Electrophysiology (science);Event;expectation;experimental study;Fiber;Frequencies;Gerbils;Goals;Hearing Aids;hearing impairment;Impairment;improved;in vivo;Individual;Language;Life;Measures;Mediating;Methods;model organism;Monitor;Music;neural;neural circuit;Neurobiology;Neurodevelopmental Disorder;neuromechanism;Neurons;Noise;non-Native;optogenetics;Pathway interactions;Perception;Perceptual learning;pharmacologic;Photometry;Population;Prefrontal Cortex;Presbycusis;presynaptic;Process;Psychometrics;response;Rewards;Role;sensory cortex;Sensory Thresholds;Shapes;Signal Transduction;skills;sound;sound frequency;Speech;Speech Development;Speech Perception;speech recognition;Stimulus;Testing;therapy design;Time;tool;Training;Viral;Work

PROJECT_TITLE: Life event supplement: Non sensory circuits for auditory perceptual learning


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Rehabilitation;Substance Misuse

ORG_CITY: Aurora

ORG_NAME: LOHOCLA RESEARCH CORPORATION

PHR: The World Health Organization in 2014 reported that alcohol contributed to more than 200 diseases and injury- related health conditions, including Alcohol Use Disorder, liver cirrhosis and cancer. Alcohol misuse is the third leading preventable cause of death in the United States and generates a significant economic burden. Lohocla Research Corporation has developed a novel therapeutic, called Nezavist, to reduce heavy alcohol consumption, including consumption by dependent individuals, and has completed nearly all nonclinical studies required to proceed to human clinical trials. The goal of this application is to complete and submit an Investigational New Drug (IND) application to the Food and Drug Administration (FDA) and, upon approval, to perform the first-in-human clinical trials of safety and tolerability of Nezavist in humans.

PI_NAMEs: TABAKOFF, BORIS  (contact)

PROGRAM_OFFICER_NAME: SENEVIRATNE, CHAMINDI

PROJECT_TERMS: ADME Study;Adult;Age;alcohol abuse therapy;Alcohol consumption;alcohol misuse;alcohol relapse;alcohol use disorder;Alcohols;Award;Benzodiazepines;Biological Availability;Brain;Cardiovascular system;Cause of Death;Characteristics;Chemistry;Clinical Trials;commercialization;Consumption;Cyclic GMP;Data;Disease;Dose;Double-Blind Method;Drug Kinetics;Drug or chemical Tissue Distribution;Drug usage;Dryness;Economic Burden;efficacy study;efficacy testing;Enrollment;Enteric Nervous System;Enzymes;Equilibrium;Excretory function;first-in-human;Formulation;Funding;GABA-A Receptor;genotoxicity;Goals;Grant;gut-brain axis;Health;Heavy Drinking;Human;In Vitro;in vivo;Individual;Injury;Institutional Review Boards;Intestines;Investigational Drugs;Investigational New Drug Application;Kilogram;Laboratory Study;Legal patent;Liver Cirrhosis;Malignant neoplasm of liver;manufacture;Marketing;Maximum Tolerated Dose;Metabolism;method development;Methods;Modeling;Molecular Target;new chemical entity;No-Observed-Adverse-Effect Level;novel;novel therapeutic intervention;novel therapeutics;Oral Administration;Outcome;Participant;Pathway interactions;Performance;Persons;Pharmaceutical Preparations;Pharmacodynamics;Phase;Phase I Clinical Trials;Phase Ia Trial;Phase Ib Clinical Trial;Phase Ib Trial;Phase II Clinical Trials;Placebo Control;positive allosteric modulator;pre-Investigational New Drug meeting;Radiolabeled;Randomized;Rattus;receptor;Recommendation;Recovery;recruit;Reporting;Research;respiratory;Rodent;Route;Safety;safety study;scale up;Site;Small Business Innovation Research Grant;Surveys;Testing;Therapeutic;therapeutically effective;Tissues;Toxicokinetics;Toxicology;United States;United States Food and Drug Administration;Work;World Health Organization

PROJECT_TITLE: Nezavist a Novel Molecule for Treatment of Alcohol Use Disorder


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities

ORG_CITY: PHILADELPHIA

ORG_NAME: NRG ONCOLOGY FOUNDATION, INC.

ORG_STATE: PA

PI_NAMEs: WOLMARK, NORMAN  (contact)

PROGRAM_OFFICER_NAME: MOONEY, MARGARET M

PROJECT_TERMS: Address;Adult;Advisory Committees;Biological Specimen Banks;Cancer Patient;Clinical Trials;cohort;Collaborations;Data Coordinating Center;Development;experience;Fostering;Goals;improved;Infrastructure;Lead;Leadership;member;Mentors;Mission;Modeling;Modernization;National Clinical Trials Network;Oncology;operation;organizational structure;Population;Productivity;programs;remote monitoring;Research;Site;statistics;success

PROJECT_TITLE: NRG Oncology Network Group Operations Center


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Chronic Liver Disease and Cirrhosis;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Hepatitis;Liver Disease;Substance Misuse

ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Project Narrative: Alcohol-associated liver disease (ALD) is a leading cause of mortality/morbidity, and there is no FDA-approved therapy for any stage of ALD. Unfortunately, patients with ALD rarely have their underlying alcohol use disorder (AUD) concomitantly addressed. This consortium links health care providers with expertise in AUD and ALD in a unified treatment strategy to evaluate novel combined treatments for AUD/ALD in patients with advanced ALD.

PI_NAMEs: CHALASANI, NAGA P (contact);OJO, OLAWALE

PROJECT_TERMS: acamprosate;Address;Adrenal Cortex Hormones;Affect;alcohol abstinence;alcohol abuse therapy;Alcohol consumption;alcohol misuse;alcohol use disorder;Alcoholic Hepatitis;Alcoholic Liver Diseases;Alcohols;anakinra;Ancillary Study;antagonist;Antimicrobial Effect;Antioxidants;Apoptotic;Behavior Therapy;Behavioral;behavioral study;Biological Specimen Banks;care outcomes;Caregivers;catalyst;Chimeric Proteins;Cirrhosis;Clinical;clinical center;Clinical Data;Clinical Treatment;Clinical Trials;cohort;Collaborations;Collection;Combined Modality Therapy;Compensation;Computers;Data;data repository;Databases;Diagnosis;Double-Blind Method;drinking;Early Intervention;Eligibility Determination;Evaluation;evidence base;FDA approved;Funding;Glucocorticoids;group counseling;Guidelines;Health Personnel;healthy volunteer;Heavy Drinking;Hospitals;improved;Individual;Informatics;Interleukin-1 Receptors;interleukin-22;Knowledge;Lactobacillus casei rhamnosus;Link;Liver;Liver diseases;longitudinal database;Masks;Measures;meetings;Morbidity - disease rate;mortality;National Institute on Alcohol Abuse and Alcoholism;new therapeutic target;novel;novel therapeutics;Observational Study;open label;optimal treatments;Outcome;patient population;Patient Preferences;patient registry;Patient-Focused Outcomes;Patients;Pattern;Pharmacotherapy;Phase;Phosphatidylethanolamine;Physicians;placebo controlled trial;Placebos;Prednisone;primary endpoint;prospective;Quality of Care;Quality of life;Randomized;randomized placebo controlled trial;Randomized, Controlled Trials;Regression Analysis;Reporting;Research Design;Research Personnel;Resource Allocation;Resources;Safety;Site;social stigma;standard of care;Steroids;Systems Biology;Testing;Thinking;Translational Research;Transplantation;treatment strategy;Zinc

PROJECT_TITLE: Integrated therapies for alcohol use and ALD (ITAALD) Network - IU Clinical Center


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Cancer;Dental, Oral, and Craniofacial Disease;Genetics;Precision Medicine;Rare Diseases

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: Project Narrative: Abnormal white patches of tissue in the mouth, or leukoplakias, are common and may become cancerous over time. This project aims to understand what events make these patches arise, and if we can predict which ones might go on to become cancer. This will permit us better select which people need treatment, as well as possible treatment strategies for these white patches.

PI_NAMEs: TWARD, AARON  (contact)

PROGRAM_OFFICER_NAME: BACCAGLINI, LORENA

PROJECT_TERMS: Address;Biological Markers;Biological Models;Biopsy;Biopsy Specimen;Cancer cell line;Cancerous;causal variant;CDKN2A gene;Cell Reprogramming;Cell Separation;Classification;clinical application;Clustered Regularly Interspaced Short Palindromic Repeats;Cold Therapy;Communities;Data;data resource;deep sequencing;Disease;driver mutation;Dysplasia;Engineering;Event;Excision;FDA approved;flexibility;Future;gene editing technology;Genes;Grant;Growth;Head and Neck Cancer;Human;Hybrids;In Vitro;Individual;individual patient;individual response;keratinocyte;Knowledge;Lesion;Leukoplakia;Low-Level Laser Therapy;Maintenance;Malignant Epithelial Cell;Malignant Neoplasms;Mediator;Modeling;Molecular;Monitor;mouth squamous cell carcinoma;Mutation;mutational status;Natural History;Neoplasms;neoplastic;next generation sequencing;novel;novel therapeutic intervention;novel therapeutics;Oral;Oral cavity;oral dysplasia;Pathogenesis;Pathologic;patient subsets;Patients;Persons;Pharmaceutical Preparations;pharmacologic;Phenotype;Phototherapy;precision medicine;Precision therapeutics;predictive marker;premalignant;Prevalence;Protein Analysis;Recurrence;Research;Resolution;response;Retinoids;Signal Transduction;Squamous cell carcinoma;standard of care;success;System;Testing;Therapeutic;Time;Tissues;transcriptome sequencing;treatment strategy;tumor progression;Uncertainty;United States;Validation;Work

PROJECT_TITLE: Defining the mutational pathogenesis of oral preneoplasia

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Chronic Liver Disease and Cirrhosis;Clinical Research;Clinical Trials and Supportive Activities;Data Science;Digestive Diseases;Hepatitis;Liver Disease;Substance Misuse

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

PHR: Project Narrative The Integrated Therapies for Alcohol use in Alcohol-associated Liver Disease (ITAALD) network, comprised of six leading partner institutions in the field, will examine novel treatments for advanced alcohol-associated liver disease. The Indiana University Data Coordinating Center will serve as a vital hub facilitating the execution of these trials and organizing the collection and storage of clinical data and biosamples generated by the network. It will also provide data analytical support to the ITAALD trials and facilitate their data dissemination.

PI_NAMEs: GAWRIEH, SAMER ;TU, WANZHU  (contact)

PROGRAM_OFFICER_NAME: PERRUCCIO, ELIZABETH M

PROJECT_TERMS: Address;Adherence;Adverse event;Alcohol consumption;alcohol research;alcohol use disorder;Alcoholic Hepatitis;Alcoholic Liver Diseases;Alcohols;Ancillary Study;biobank;Biological Specimen Banks;Catalogs;Cirrhosis;Clinical;clinical center;Clinical Data;clinical database;clinical investigation;Clinical Management;clinical phenotype;Clinical Trials;Clinical Trials Data Monitoring Committees;Collaborations;Collection;Communication;Data;data access;Data Analyses;Data Analytics;Data Collection;Data Commons;Data Coordinating Center;data dissemination;Data Element;data infrastructure;data integrity;data management;data modeling;data sharing;design;effective therapy;Eligibility Determination;Ensure;evidence based guidelines;experience;FAIR principles;FDA approved;Fostering;Funding;Genetic;Goals;improved;Indiana;Infrastructure;Institution;Investigational New Drug Application;knowledge translation;Link;Liver;Liver diseases;Massachusetts;medical schools;Metadata;Methodology;Monitor;Morbidity - disease rate;mortality;Multi-Institutional Clinical Trial;National Institute on Alcohol Abuse and Alcoholism;novel;Observational Study;operation;Outcome;Patients;Pharmaceutical Preparations;Pharmacy facility;Phase;Play;Policies;Procedures;Productivity;protocol development;Protocols documentation;Publications;Publishing;quality assurance;randomized, clinical trials;Randomized, Controlled Trials;Reporting;Reproducibility;Research;Research Activity;Research Design;Research Infrastructure;Research Methodology;Research Support;response;Role;Safety;Scientist;searchable database;secondary analysis;Secure;Site;Standardization;Steroids;success;synergism;System;tool;treatment strategy;Universities;Visualization;Work

PROJECT_TITLE: Integrated Therapies for Alcohol use in Alcohol-associated Liver Disease (ITAALD) - Indiana University Data Coordinating Center


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative

ORG_CITY: HADLEY

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF MASSACHUSETTS AMHERST

PHR: There are currently no effective treatments for tauopathies, such as Alzheimer’s Disease (AD). Uptake and spreading of pathogenic tau is recognized as a key driver of AD pathology, and is primarily mediated by tau's interaction with the cellular receptor LRP1. Molecular dissection of the tau-LRP1 interaction will enable us to devise new therapies for AD.

PI_NAMEs: RAUCH, JENNIFER NICOLE (contact)

PROGRAM_OFFICER_NAME: YANG, AUSTIN JYAN-YU

PROJECT_TERMS: 3-Dimensional;Acetylation;Affinity;Alternative Splicing;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease pathology;Alzheimer's disease therapeutic;Alzheimer's disease therapy;Amber;Biochemical;Biological;Biological Assay;Brain;Cell Culture Techniques;Cells;Charge;Codon Nucleotides;comparison control;Complex;Cryoelectron Microscopy;density;Deposition;Development;Disease;Disease Progression;Dissection;effective therapy;Electrostatics;Elements;Evaluation;Fluorescence Resonance Energy Transfer;Genetic;Goals;Human;human disease;human induced pluripotent stem cells;In Vitro;in vivo;Induced pluripotent stem cell derived neurons;innovation;insight;Intervention;knock-down;Knowledge;LDL-Receptor Related Protein 1;Learning;Ligands;Link;Lipoprotein Receptor;Lysine;Maps;Mass Spectrum Analysis;Measures;Mediating;Methods;Modeling;Modification;Molecular;Mus;Neurodegenerative Disorders;novel;novel therapeutics;Pathogenicity;Pathologic;Pathway interactions;Phosphorylation;Point Mutation;Post-Translational Protein Processing;prevent;Process;protein aggregation;Protein Isoforms;protein protein interaction;Proteins;Protocols documentation;Publishing;receptor;Regulation;Sampling;Site;Structure;Surface;tau aggregation;tau interaction;tau mutation;tau Proteins;tau-1;Tauopathies;Technology;Testing;therapeutic target;treatment strategy;Ubiquitin;Ubiquitination;unnatural amino acids;unpublished works;uptake;Work

PROJECT_TITLE: Deciphering the Molecular Features Underlying LRP1-Mediated Tau Spread

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND-R]


ADMINISTERING_IC: NS

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Disability Research;Neurosciences;Physical Rehabilitation;Rehabilitation

ORG_CITY: TUCSON

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: Narrative Over 1.7 million people suffer from limb loss in the United States and this number is estimated to increase by 185,000 per year for upper extremity loss. Sophisticated limb robotic limb prosthetics have increased dramatically the intuitive control, but evoking a naturalistic sensation from the engineered sensors in the bionic limb to the amputee users, remain a formidable challenge. We propose to develop a highly selectivity regenerative peripheral nerve interface that uses small electrodes, and molecularly guided motor and sensory subtype axonal defasciculation to improve neural interfacing of amputated nerves.

PI_NAMEs: ROMERO-ORTEGA, MARIO IGNACIO (contact)

PROGRAM_OFFICER_NAME: KUMSA, DOE WONDWOSSEN

PROJECT_TERMS: Adult;Afferent Neurons;age acceleration;Amputation;Amputees;Animals;Area;arm;Axon;base;Biomedical Engineering;Bionics;Charge;Chemicals;cognitive load;Cues;Cutaneous;Data;design;Deterioration;Devices;Diameter;Distal;efficacy evaluation;Elbow;electric impedance;Electric Stimulation;Electrodes;Electromyography;Electron Microscopy;Engineering;Esthesia;experimental group;Failure;Freedom;glial cell-line derived neurotrophic factor;grasp;Growth Factor;Hand;Histology;Human;Implant;improved;Individual;innovation;Intuition;kinematics;limb loss;limb movement;Limb Prosthesis;Limb structure;Locomotion;Maps;Measurement;mechanical properties;Mechanics;median nerve;meter;Methods;microstimulation;Modality;Modeling;Molecular;Morphologic artifacts;Motion;Motor;motor control;Motor Cortex;Movement;multi-electrode arrays;Muscle;Natural regeneration;Nerve;neural;neuroprosthesis;neurotransmission;novel strategies;Paraplegia;Pathway interactions;Patients;Pattern;Periodicity;Peripheral;Peripheral Nerves;Peripheral Nervous System;Persons;Physiology;pleiotrophin;Population;Positioning Attribute;powered prosthesis;Property;Proprioception;Prosthesis;prosthesis control;Rattus;Reading;regenerative;residual limb;response;robot control;Robotics;sciatic nerve;sensor;Sensory;sensory feedback;Shapes;Signal Transduction;silicon carbide;Site;Skin;somatosensory;Somatosensory Cortex;Spectrum Analysis;Sting Injury;Structure of ulnar nerve;Surface;Tactile;Testing;Thalamic structure;Time;Touch sensation;Training;Translating;treadmill;United States;Upper Extremity;Utah;Viral;Visual;visual feedback;voltage

PROJECT_TITLE: Regenerative Ultramicroelectrode arrays for sensory-motor specific interfacing


ORG_CITY: BROOKLYN

ORG_DEPT: PSYCHIATRY

ORG_NAME: SUNY DOWNSTATE MEDICAL CENTER

ORG_STATE: NY

PHR: Project Narrative Alcohol use disorder (AUD) is a leading contributor to mental, physical and cognitive disability, and preventable death in the US, particularly in those 40 years old and older. The Collaborative Study on the Genetics of Alcoholism (COGA) is a tightly integrated and interdisciplinary project, whose overarching goals are to understand the contributions and interactions of genetic, neurobiological, behavioral and social-environmental factors on risk and resilience over the developmental course of AUD, including remission and recurrence; the three COGA projects (Lifespan, Brain Function, and Genomics), supported by three cores (Administrative, Data Management Coordination and NIAAA/COGA Sharing Repository) aim to address the public health challenge of AUD by integrating findings across multiple domains of research. Combining our multidisciplinary expertise with our single mission, COGA can traverse the path from genes to brain to behavior across the lifespan and lay the foundation for precision medicine efforts.

PI_NAMEs: AGRAWAL, ARPANA ;HESSELBROCK, VICTOR M;PORJESZ, BERNICE  (contact)

PROGRAM_OFFICER_NAME: POWELL, ELIZABETH

PROJECT_TERMS: Achievement;Address;Adverse effects;adverse outcome;Affect;Affective;Age;age related;aged;Alcohol consumption;alcohol related consequences;alcohol research;alcohol response;alcohol use disorder;Alcohols;Autopsy;Behavior;Behavioral;behavioral health;Biological;Biological Specimen Banks;Biology;Brain;brain health;Brain region;brain shape;Cell Nucleus;Cells;Characteristics;Chromatin;Clinical;Clinical Assessment Tool;clinical care;Cognitive;cognitive disability;Collaborations;Data;Data Collection;data management;Data Set;data sharing;Development;Developmental Course;Disease remission;economic cost;Electroencephalography;Environment;Environmental Risk Factor;Etiology;Family;Family member;Foundations;Gene Expression;Generations;Genes;Genetic;Genetic Risk;Genetic study;genetic variant;genetics of alcoholism;genome-wide;genomic data;Genomics;Goals;Healthcare;Heavy Drinking;high risk;high risk drinking;Human;human old age (65+);Impaired cognition;Individual;induced pluripotent stem cell;insight;Knowledge;late life;life span;Link;longitudinal course;Longitudinal Studies;Measures;Memory;Mental disability;Mental Health;Methylation;middle age;Mission;Modality;Modeling;Molecular;mortality;multidisciplinary;multimodality;multiple omics;National Institute on Alcohol Abuse and Alcoholism;Nature;neural;Neurobiology;Neurocognitive;neurodevelopment;Neurons;neurophysiology;neuropsychiatry;Neuropsychology;Outcome;Participant;Pathway interactions;Pattern;Phenotype;phenotypic data;physical conditioning;physically handicapped;Population;population health;Positioning Attribute;precision medicine;preventable death;Process;Productivity;protective factors;psychologic;Public Health;Recording of previous events;Recurrence;Reporting;Research;Research Personnel;resilience;resilience factor;response;Risk;Risk Factors;risk variant;Role;Sampling;Science;shared repository;social;Social Environment;Specificity;synergism;Time;transcriptomics;Translating;Variant;Woman;Work

PROJECT_TITLE: Collaborative Study on the Genetics of Alcoholism (COGA).

STUDY_SECTION_NAME: Special Emphasis Panel[ZAA1 CC (03)]


NIH_SPENDING_CATS: Aging;Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Clinical Research;Genetics;Mental Health;Neurosciences;Substance Misuse

PI_NAMEs: PORJESZ, BERNICE  (contact)

PROJECT_TERMS: Achievement;Address;adverse outcome;Affect;Age;aged;Alcohol consumption;alcohol related consequences;alcohol research;alcohol use disorder;Alcohols;Behavioral;behavioral health;Biocompatible Materials;Biological Specimen Banks;Brain;brain health;brain shape;Budgets;Clinical;clinical care;Clinical Research;Collaborations;Communication;Communities;Data;data archive;Data Collection;data management;Data Set;data sharing;database of Genotypes and Phenotypes;design;Disease remission;Education;effective intervention;Ensure;Environmental Risk Factor;Family;Family member;Genetic;Genetic Research;Genetic study;genetics of alcoholism;genome-wide;genomic data;Genomics;Goals;Healthcare;Heavy Drinking;Impaired cognition;information gathering;Infrastructure;insight;Institution;International;late life;life span;longitudinal course;meetings;member;Mental Health;Mission;Modality;Molecular;mortality;multidisciplinary;National Institute on Alcohol Abuse and Alcoholism;neural;Neurobiology;Neurocognitive;neurophysiology;neuropsychiatry;Neuropsychology;Outcome;outreach;Persons;phenotypic data;physical conditioning;Play;population health;Positioning Attribute;precision medicine;Productivity;Public Health;Publications;Qualifying;Recording of previous events;Recurrence;Reporting;Research;Research Personnel;Research Project Grants;research study;resilience;resilience factor;Resource Sharing;Resources;response;Risk;Risk Factors;Role;Sampling;Science;Scientific Advances and Accomplishments;Scientist;shared repository;Site;social;socioenvironmental factor;Structure;symposium;synergism;trait;Translating;translational genetics;U-Series Cooperative Agreements;United States National Institutes of Health;Update;web site;Woman;Work

PROJECT_TITLE: COGA Administrative Core


NIH_SPENDING_CATS: Aging;Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Clinical Research;Data Science;Genetics;Human Genome;Mental Health;Networking and Information Technology R&D (NITRD);Neurosciences;Substance Misuse

PI_NAMEs: HARTZ, SARAH  (contact)

PROJECT_TERMS: Achievement;Address;adverse outcome;Affect;Affective;Age;aged;Agreement;Alcohol consumption;alcohol related consequences;alcohol research;alcohol risk;alcohol use disorder;Alcohols;Algorithms;Archives;Behavioral;behavioral health;Biocompatible Materials;Biological Specimen Banks;Brain;brain health;brain shape;Clinical;clinical care;Clinical Data;Code;Collaborations;Collection;Communities;Computer Assisted;Computer software;Data;data archive;data cleaning;Data Collection;data collection site;data management;Data Set;data sharing;data visualization;database of Genotypes and Phenotypes;Databases;Disease remission;distributed data;Electroencephalography;Electrophysiology (science);Ensure;Environmental Risk Factor;FAIR principles;Family;Family member;Gene Expression;Genes;Genetic;Genetic Risk;Genetic study;genetics of alcoholism;genome-wide;genomic data;Genomics;Goals;Harvest;Healthcare;Heavy Drinking;Impaired cognition;Individual;insight;Interview;late life;life span;Link;longitudinal course;Measures;Mental Health;Meta-Analysis;Metadata;Modality;Molecular;Monitor;mortality;multimodality;Multiomic Data;National Institute on Alcohol Abuse and Alcoholism;Neurobiology;Neurocognitive;neuroimaging;neurophysiology;Neuropsychology;Outcome;Participant;Phenotype;phenotypic data;physical conditioning;population health;Positioning Attribute;Procedures;Process;Productivity;programs;protective factors;psychiatric genomics;Psychopathology;Public Health;Qualifying;Recording of previous events;recruit;Recurrence;Reporting;repository;Research;Research Personnel;resilience factor;response;Risk;Risk Factors;Role;Sampling;scaffold;Science;Scientist;Secure;shared repository;Site;social;Structure;Substance Use Disorder;Surveys;synergism;System;trait;Translating;user-friendly;Visualization;web site;Work

PROJECT_TITLE: Data Management Core


NIH_SPENDING_CATS: Aging;Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Biotechnology;Clinical Research;Genetics;Human Genome;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Substance Misuse

PI_NAMEs: TISCHFIELD, JAY ARNOLD (contact)

PROJECT_TERMS: Achievement;Address;adverse outcome;Affect;Age;aged;Alcohol consumption;alcohol related consequences;alcohol research;alcohol use disorder;Authorization documentation;Behavioral;behavioral health;biobank;Biocompatible Materials;Biological;Biological Specimen Banks;Blood;Blood specimen;Brain;brain health;brain shape;Cell Line;cell repository;Cell Reprogramming;Clinical;clinical care;Clinical Data;Collaborations;Collection;Communication;Consent;CRISPR/Cas technology;Cryopreservation;Data;Data Collection;data management;Data Set;data sharing;Disease remission;DNA;DNA Sequence;Environmental Risk Factor;epigenomics;experience;Family;Family member;Fee-for-Service Plans;Funding;Future;Gene Modified;Genetic;Genetic Research;Genetic study;genetic variant;genetics of alcoholism;genome editing;Genome Stability;genome-wide;genomic data;genomic platform;Genomics;Genotype;Goals;Grant;Healthcare;Heavy Drinking;Impaired cognition;induced pluripotent stem cell;insight;late life;Leadership;life span;Liquid substance;longitudinal course;lymphoblastoid cell line;Lymphocyte;Mechanics;Mental Health;metabolomics;Methodology;Modality;Molecular;Molecular Weight;Monitor;mortality;National Institute of Drug Abuse;National Institute on Alcohol Abuse and Alcoholism;Neurobiology;Neurons;neurophysiology;Neuropsychology;Nitrogen;Outcome;Participant;Peripheral Blood Mononuclear Cell;phenotypic data;physical conditioning;Plasma;pluripotency;population health;Positioning Attribute;Process;Productivity;Proteomics;Public Health;Publications;Quality Control;Recording of previous events;Recurrence;Reporting;repository;Research;Research Personnel;resilience factor;Resources;response;Risk;Risk Factors;RNA;Role;Saliva;Sampling;Science;Scientist;Secure;shared repository;Site;social;synergism;Technology;Testing;Time;Translating;Validation

PROJECT_TITLE: COGA Cell Repository


NIH_SPENDING_CATS: Aging;Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Genetics;Human Genome;Mental Health;Neurosciences;Prevention;Substance Misuse

PI_NAMEs: SALVATORE, JESSICA E (contact)

PROJECT_TERMS: Abstinence;Achievement;Address;Adult;adverse outcome;Affect;Affective;African American;Age;aged;alcohol consequences;Alcohol consumption;alcohol related consequences;alcohol research;alcohol use disorder;Alcohols;Behavior;Behavioral;behavioral health;binge drinking;Biological Specimen Banks;Biomedical Research;Brain;brain health;brain shape;Cause of Death;Cessation of life;Clinical;clinical care;Collaborations;Communities;Data;Data Collection;data management;Data Set;data sharing;Development;Disease;Disease remission;drinking behavior;Emotional;Environment;Environmental Risk Factor;Etiology;Family;Family member;follow up assessment;follow-up;Genes;Genetic;genetic pedigree;Genetic Risk;Genetic study;genetics of alcoholism;genome-wide;genomic data;Genomics;Genotype;Goals;Health;Healthcare;Heavy Drinking;high risk drinking;Impaired cognition;indexing;Individual;Individual Differences;innovation;insight;Interview;Knowledge;knowledge base;late life;life span;Link;longitudinal course;Longitudinal Studies;Maps;Mental Health;Modality;Molecular;mortality;multimodal data;National Institute on Alcohol Abuse and Alcoholism;Neurobiology;Neurocognitive;neurophysiology;Neuropsychology;Outcome;Participant;Pattern;phenotypic data;physical conditioning;Population;population health;Positioning Attribute;preventive intervention;Preventive treatment;Productivity;psychologic;Public Health;Questionnaires;Recording of previous events;Records;Recurrence;Reporting;Research;Research Personnel;resilience factor;response;Risk;Risk Factors;Role;Sampling;Science;shared repository;social;Source;synergism;Time;Translating;Work

PROJECT_TITLE: Lifespan Project


NIH_SPENDING_CATS: Aging;Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Mental Health;Neurosciences;Social Determinants of Health;Substance Misuse

PI_NAMEs: MEYERS, JACQUELYN LEIGH (contact)

PROJECT_TERMS: Acceleration;Achievement;Address;advanced analytics;Adverse effects;adverse outcome;Affect;Affective;African American population;Age;aged;Aging;aging brain;alcohol consequences;Alcohol consumption;alcohol effect;alcohol related consequences;alcohol research;alcohol use disorder;Alcohols;analytical method;Attention;Attenuated;Behavioral;behavioral health;Big Data;Biological Markers;Biological Specimen Banks;Brain;brain dysfunction;brain health;brain shape;Chronology;Clinical;clinical care;Collaborations;Communication;Complex;Data;Data Collection;data management;Data Set;data sharing;Disease remission;disorder risk;drinking;Electroencephalography;emotion regulation;Emotions;Environmental Risk Factor;Episodic memory;Exposure to;Family;Family member;family support;Gender;Genetic;Genetic study;genetics of alcoholism;genome wide association study;genome-wide;genomic data;genomic locus;Genomics;Goals;Health;Healthcare;Heavy Drinking;Impaired cognition;Individual;insight;Interview;Knowledge;late life;Life;life span;longitudinal course;Machine Learning;machine learning model;machine learning prediction;Measures;Memory;Mental Depression;Mental Health;Methods;Modality;Molecular;mortality;National Institute on Alcohol Abuse and Alcoholism;Nerve Degeneration;neural network;Neurobiology;Neurocognitive;neurophysiology;neuropsychiatry;Neuropsychology;novel;older adult;Older Population;Outcome;Participant;Pattern;Phenotype;phenotypic data;physical conditioning;population health;Positioning Attribute;Productivity;protective effect;Psyche structure;Public Health;Recording of previous events;Recurrence;Reporting;Research;Research Personnel;resilience factor;response;reward processing;Risk;Risk Factors;Role;Sampling;Science;Self Medication;sex;shared repository;social;social engagement;Social Environment;Social support;stressor;synergism;Time;trait;Translating;Underrepresented Populations

PROJECT_TITLE: Brain Function Project


NIH_SPENDING_CATS: Aging;Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Biotechnology;Brain Disorders;Clinical Research;Genetics;Human Genome;Mental Health;Neurosciences;Prevention;Substance Misuse

PI_NAMEs: LIU, YUNLONG  (contact)

PROJECT_TERMS: Achievement;Address;adverse outcome;Affect;Age;aged;Alcohol abuse;Alcohol consumption;alcohol effect;alcohol exposure;alcohol related consequences;alcohol research;alcohol response;alcohol sensitivity;alcohol use disorder;Amygdaloid structure;ATAC-seq;Autopsy;Behavior;Behavioral;behavioral health;Biocompatible Materials;Biological;Biological Assay;Biological Specimen Banks;Brain;brain health;brain shape;cell repository;cell type;Cells;Chromatin;Clinical;clinical care;Collaborations;comorbidity;Data;Data Collection;data integration;data management;Data Set;data sharing;Development;Disease remission;disorder risk;Environment;Environmental Risk Factor;Ethanol;Family;Family member;Gene Expression;gene network;Genes;Genetic;genetic architecture;Genetic Predisposition to Disease;Genetic study;genetics of alcoholism;genome wide association study;genome-wide;genomic data;Genomics;Goals;Health;Healthcare;Heavy Drinking;Human;Hypothalamic structure;Impaired cognition;Individual;induced pluripotent stem cell;Induced pluripotent stem cell derived neurons;insight;late life;life span;longitudinal course;men;Mental Health;Methods;Methylation;Modality;Modeling;Molecular;mortality;multimodality;Multiomic Data;multiple omics;National Institute on Alcohol Abuse and Alcoholism;Neurobiology;Neuronal Differentiation;Neurons;neurophysiology;Neuropsychology;novel;novel therapeutics;Outcome;Participant;Pathway interactions;personalized approach;Phenotype;phenotypic data;physical conditioning;Population;population health;Positioning Attribute;Productivity;Psyche structure;Public Health;Recording of previous events;Recurrence;Regulatory Pathway;Reporter;Reporting;Research;Research Personnel;resilience;resilience factor;response;Risk;Risk Factors;risk variant;Role;Sampling;Science;shared repository;single nucleus RNA-sequencing;social;Source;Structure of middle temporal gyrus;synergism;Tissues;trait;Translating;Woman

PROJECT_TITLE: Genomics Project


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: LOS ANGELES

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative Advanced age is the greatest risk factor for the onset and progression of Alzheimer's disease. We are using the powerful genetics of the fruit fly Drosophila to better understand the biological mechanisms of aging. The long-term goal of this research is to provide novel therapeutic targets to counteract age-related human diseases, including Alzheimer's disease.

PI_NAMEs: WALKER, DAVID W (contact)

PROGRAM_OFFICER_NAME: FU, YI-PING

PROJECT_TERMS: Adult;age related;age-related disease;aged;Aging;aging brain;aging mechanism;aging related;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease patient;Alzheimer's disease related dementia;Alzheimer's disease risk;Animals;Biological;Body System;Brain;Cell model;Cytosol;Deoxyribonucleases;DNA;drivers of aging;Drosophila genus;effective therapy;Elderly;extend lifespan;fly;Genetic;genetic approach;Goals;Health;healthspan;Homeostasis;Immune signaling;Inflammatory;Inflammatory Response;Knowledge;Link;Mitochondria;mitochondrial autophagy;Mitochondrial DNA;mitochondrial dysfunction;Neurons;new therapeutic target;novel therapeutic intervention;parent grant;Pathogenesis;Pathology;Process;Reporting;Research;Risk Factors;Role;sensor;Signal Transduction;Stress;targeted treatment;Therapeutic Intervention;Work

PROJECT_TITLE: Role of Mitochondrial Homeostasis in Animal Aging


NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Genetics;Heart Disease;Orphan Drug;Pediatric;Pediatric Cardiomyopathy;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: NARRATIVE Dilated cardiomyopathy (DCM) is a prevalent cause of heart failure and death. We identified a set of candidate therapeutic genes that will be investigated to determine whether they will be good drug targets using human in vitro models, human population genetics, and a mouse in vivo model of DCM. This diversity supplement will support an aspiring physician-scientist as he investigates whether drugs that target the genes we have identified might be beneficial for the treatment of DCM.

PI_NAMEs: MERCOLA, MARK  (contact);SUBRAMANIAM, SHANKAR

PROGRAM_OFFICER_NAME: SCHWARTZ, LISA

PROJECT_TERMS: Administrative Supplement;Affect;Antioxidants;Bachelor's Degree;Biochemical;Cardiac Myocytes;Cardiology;career;Career Mobility;Cessation of life;Characteristics;Clinical;CRISPR correction;Dilated Cardiomyopathy;Disease;Doctor of Philosophy;drug repurposing;Drug Targeting;endoplasmic reticulum stress;familial dilated cardiomyopathy;Functional disorder;Gene Mutation;Genes;Genetic;genetic variant;Heart failure;Hispanic Americans;Human;Human Genetics;human induced pluripotent stem cells;human population genetics;improved;in vitro Model;in vivo Model;Individual;Instruction;Mediating;Mentors;Microfilaments;MicroRNAs;Modeling;mortality;mouse model;Mus;Muscle Proteins;mutant;Mutation;Myocardium;new therapeutic target;novel therapeutics;parent project;Parents;Pathway interactions;Patients;Pharmaceutical Preparations;Physicians;Physiology;Process;programs;Scientist;Signal Transduction;Small Interfering RNA;Symptoms;Testing;Therapeutic;therapeutic candidate;therapeutic gene;Therapeutic Intervention;Training;Variant

PROJECT_TITLE: MicroRNA Control of Dilated Cardiomyopathy


ADMINISTERING_IC: OD

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

FUNDING_MECHANISM: OTHERS

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Data Science;Networking and Information Technology R&D (NITRD)

ORG_CITY: AUSTIN

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

PI_NAMEs: FONNER, JOHN M. (contact);NEKRUTENKO, ANTON ;SCHATZ, MICHAEL ;SMALLEN, SHAVA

PROGRAM_OFFICER_NAME: PAPANICOLAOU, GEORGE

PROJECT_TERMS: Accounting;Address;Adoption;Archives;Area;Authorization documentation;bioinformatics tool;Biomedical Research;broadening participation research;Cloud Computing;Collaborations;Communities;Complex;computing resources;cost;cost estimate;Custom;Data;Data Analyses;data ecosystem;data integration;Data Set;data sharing;Data Storage and Retrieval;design;Documentation;Education and Outreach;Ensure;Environment;experience;flexibility;Funding;Galaxy;Goals;Infrastructure;Ingestion;innovation;interest;interoperability;Investments;large datasets;large scale data;Leadership;Link;Manuals;Measures;Movement;multiple omics;online tutorial;open data;open source;outreach;Pain;Performance;portability;Privatization;programs;Recording of previous events;Reporting;Research;Research Personnel;Resources;Rights;satisfaction;Science;Scientist;skills;Software Engineering;Software Tools;Source;Speed;success;Supercomputing;Texas;tool;Training;United States National Institutes of Health;user-friendly;Vision;Work

PROJECT_TITLE: The CFDE Cloud Workspace

STUDY_SECTION: CFOT

STUDY_SECTION_NAME: Common Fund Other Transactions Programs[CFOT (02)]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE The purpose of this supplement is to build the early career of an emerging Latina clinician- researcher. The project’s purpose will be accomplished through supplemental work on an existing funded grant. The supplement aims to increase participation of the United States (US) Latinx community in clinical trials for neurodevelopmental disorders. The proposed project has broad public health relevance because it will improve access of US Latinx families to clinical research interventions. Data from this project will inform approaches to enhance research participation in neurodevelopmental disorder related clinical trials among the Latinx community, which is well aligned with the NICHD’s mission.

PI_NAMEs: MAITRE, NATHALIE  (contact)

PROGRAM_OFFICER_NAME: MARDEN, SUSAN F

PROJECT_TERMS: Address;Belief;career;career development;Caregivers;Caring;Case Manager;Case/Control Studies;Child;Child Rearing;Clinic;Clinical;clinical care;Clinical Research;Clinical Trials;Communities;Community Participation;culturally appropriate intervention;Data;Decision Making;Dedications;design;Diagnosis;Disabled Children;Early Diagnosis;Economic Conditions;Education;Effectiveness;Effectiveness of Interventions;Eligibility Determination;empowerment;Enrollment;Ensure;experience;Family;Funding;Geography;Goals;Grant;health care disparity;health literacy;Health Services Accessibility;Healthcare;Healthcare Systems;high risk;Holistic Health;Immigrant;Improve Access;improved;Infant;insight;Intervention;Interview;Language;Latin American;Latina;Latinx;Limited English Proficiency;Manuals;marginalization;Mental Depression;Mentorship;Minority Groups;Mission;Mothers;Motor;National Institute of Child Health and Human Development;Neurodevelopmental Disorder;operation;Outcome;parenting intervention;Parents;Participant;Perception;Persons;Physicians;poor health outcome;Population;primary outcome;Psychologist;public health relevance;Qualitative Research;Records;rehabilitation research;Reporting;Research;Research Assistant;Research Personnel;research study;Research Training;Resources;Sampling;Scientist;secondary outcome;Site;social health determinants;social relationships;sociodemographics;socioeconomics;Spanish;Stress;Students;success;Therapeutic;Time;Translations;underserved community;United States;Upper Extremity;volunteer;Work

PROJECT_TITLE: APPLES-tele Diversity Supplement