NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Genetics;Hematology;Infectious Diseases;Machine Learning and Artificial Intelligence;Orphan Drug;Pediatric;Precision Medicine;Primary Immunodeficiencies;Rare Diseases;Sepsis

ORG_CITY: PITTSBURGH

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Narrative Every year over 1 million American adults and children develop overwhelming infection leading to a rotting of their body we call ‘sepsis’ and death in up to 1 of 4 afflicted, caused by too much inflammation, too little immunity, and toxic metabolism. In our previous funding period, we used ‘Watson’-like and ‘Twenty three and me’ and ‘Ancestry.com’-like machine learning approaches to figure out how to help each child to reduce inflammation and restore ability to kill infection with individually tailored treatments. We next figure out how to restore normal metabolism so that each child can live their longest and happiest life.

PI_NAMEs: CARCILLO, JOSEPH A (contact)

PROGRAM_OFFICER_NAME: ZHAO, XIAOLI

PROJECT_TERMS: Address;Adult;aerobic glycolysis;American;Anti-Inflammatory Agents;Autoimmunity;Big Data;biobank;Bioinformatics;Biological Assay;CCL2 gene;Cessation of life;Characteristics;Child;chronic infection;Clinical;Clinical Data;Clinical Trials;Clinical Trials Design;Coagulation Process;Computers;congenital immunodeficiency;Cytochrome P450;cytokine;Data Set;design;Disease;drug repurposing;Energy Metabolism;Enrollment;Epigenetic Process;Epstein-Barr Virus Infections;Epstein-Barr Virus latency;exome;Funding;Genes;genetic variant;Glucose;high risk;Hour;Human Genetics;Human Herpesvirus 4;Immune;Immune response;Immunity;Immunoglobulin G;immunoregulation;Immunotherapy;improved;Inborn Errors of Metabolism;Individual;individual patient;individualized medicine;Infection;Inflammation;Inflammatory;Laboratories;Latent virus infection phase;Lead;Life;Link;Long COVID;Lymphopenia;Machine Learning;Macrophage Activation;Macrophage activation syndrome;Malignant Neoplasms;Measures;Mediating;Metabolic;Metabolic Pathway;Metabolism;metabolomics;Metformin;Methylation;Molecular;Molecular Biology;mortality;Multiple Organ Failure;Multiple Sclerosis;Names;next generation sequencing;novel;novel therapeutics;Organ;Organ failure;Outcome;Oxidative Phosphorylation;pathogen;Pathogenicity;Patients;pediatric sepsis;personalized medicine;Phenotype;Placebo Control;Plasma;precision medicine;Precision medicine trial;Proliferating;Research;Research Personnel;response;Rheumatoid Arthritis;Role;Sampling;Sepsis;septic;septic patients;Subgroup;Systemic Lupus Erythematosus;targeted treatment;Technology;Testing;Therapy trial;Thrombocytopenia;thrombotic;United States;Variant;Virus;virus genetics

PROJECT_TITLE: Inflammation Phenotypes in Pediatric Sepsis Induced Multiple Organ Failure Renewal

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


ADMINISTERING_IC: HL

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Genetics;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Obesity;Prevention;Racial and Ethnic Minority Health Research

ORG_COUNTRY: UNITED STATES

ORG_DEPT: GENETICS

ORG_FIPS: US

ORG_STATE: PA

PHR: NARRATIVE Title: Lipidomics and structural genomics of cardiometabolic health in Samoan adults Project Period: 04/01/2023–03/31/2027 This project will explore the relationships between lipids, genes, environment, heart health, and obesity-related traits among Samoans, a Pacific Islander population with high rates of diseases like type 2 diabetes and heart disease. This study will focus on the lipidome, made up of biologically simpler lipid species than conventional cholesterol measurements, and on structural changes in the genome, which are expected to have larger effects than simpler genetic variants. Our discoveries will improve our understanding of the basic biology of lipids and how they affect heart health and obesity-related traits. We will also identify potential targets for interventions to improve health overall.

PI_NAMEs: MINSTER, RYAN LEE (contact)

PROGRAM_OFFICER_NAME: COADY, SEAN

PROJECT_TERMS: Address;Adult;Affect;Alcohol consumption;American;American Samoa;ancestry analysis;Architecture;Asian Americans;Biological;Biology;Blood Pressure;Cardiac health;Cardiometabolic Disease;cardiometabolism;Cholesterol;community advisory board;community partnership;comorbidity;Complex;Data;Data Analyses;Data Set;diabetes risk;Dietary Practices;Disease;Environment;epidemiology study;Etiology;experience;fasting glucose;Feedback;Funding;Genes;Genetic;Genetic Determinism;genetic variant;Genetic Variation;Genome;genome wide association study;genome-wide;Genomics;Genotype;Health;Heart Diseases;high body mass index;High Density Lipoprotein Cholesterol;high risk;improved;Individual;insight;Interdisciplinary Study;Intervention;Investigation;Knowledge;Lead;lipidome;lipidomics;Lipids;lipoprotein triglyceride;Maps;Measurement;Measures;Mendelian randomization;Mission;modifiable risk;Molecular;National Heart, Lung, and Blood Institute;Native Hawaiian or Other Pacific Islander;Non-Insulin-Dependent Diabetes Mellitus;novel;Nucleotides;Obesity;obesity risk;Outcome;Overweight;Pacific Islander;Participant;Pattern;Persons;Phenotype;Polynesian;Population;Population Heterogeneity;Positioning Attribute;programs;Research;response;Risk Factors;Samoa;Samoan;Sampling;sedentary;Serum;Socioeconomic Status;Source;structural genomics;System;Testing;Tobacco use;trait;Trans-Omics for Precision Medicine;United States National Institutes of Health;Variant;Voice;Work

STUDY_SECTION: KEDD

STUDY_SECTION_NAME: Kidney Endocrine and Digestive Disorders Study Section[KEDD]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Infectious Diseases;Neurosciences

ORG_CITY: LOS ANGELES

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: PROJECT NARRATIVE Skin-penetrating parasitic nematodes infect nearly a billion people and are a major cause of morbidity worldwide. This grant will investigate the behavioral, neural, and molecular mechanisms that underlie the process of skin penetration in these parasites. Our results will illuminate how skin-penetrating nematodes invade human hosts and may enable the development of novel nematode control strategies.

PI_NAMEs: HALLEM, ELISSA ANYON (contact)

PROGRAM_OFFICER_NAME: PESCE, JOHN T

PROJECT_TERMS: Agar;Ancylostoma (genus);Anthelmintics;Behavior;Behavioral;Behavioral Mechanisms;behavioral response;Biological Assay;Body Temperature;Caenorhabditis elegans;Calcium;Cessation of life;Child;chronic gastrointestinal distress;Clustered Regularly Interspaced Short Palindromic Repeats;Cream;CRISPR/Cas technology;Cues;Development;Distant;Dopamine;dopaminergic neuron;Enterobius;Evolution;experimental study;Exposure to;gastrointestinal;Genes;Genetic;genetic manipulation;Grant;Growth;Hookworms;Human;Image;Impaired cognition;In Vitro;in vivo calcium imaging;in vivo monitoring;Infection;Ingestion;Insect Repellents;insight;Intervention;Invaded;Larva;Life;Life Cycle Stages;Lotion;Mechanics;mechanotransduction;Mediating;Methods;Modeling;Molecular;Morbidity - disease rate;Mutagenesis;Necator;Nematoda;neural;neuromechanism;Neurons;novel;Parasites;Parasitic nematode;Pathway interactions;Penetration;Persons;Process;programs;Property;Rattus;receptor;Resource-limited setting;response;Role;Sensory;Signal Transduction;Skin;Soil;Source;Strongyloides;Strongyloides ratti;Strongyloides stercoralis;Surface;Temperature;Testing;Texture;Touch sensation

PROJECT_TITLE: Mechanisms of skin penetration in skin-penetrating parasitic nematodes

STUDY_SECTION: PTHE

STUDY_SECTION_NAME: Pathogenic Eukaryotes Study Section[PTHE]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences;Nutrition

ORG_CITY: SEATTLE

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative The retinal pigment epithelium is the outer retina/blood barrier so it can influence the flow of fuel to the retina. It also stores fuels as glycogen and fat. We will determine the metabolic roles of the stored fuels and how they are influenced by diurnal cycles.

PI_NAMEs: HURLEY, JAMES BRYANT (contact)

PROGRAM_OFFICER_NAME: NEUHOLD, LISA

PROJECT_TERMS: Acidity;aerobic glycolysis;Affect;Age related macular degeneration;Aging;Blindness;Blood;Blood-Retinal Barrier;Cell Death;Cell membrane;Cells;Choroid;circadian;Circulation;Consumption;Cytoplasm;Disease;Energy-Generating Resources;Environment;Environmental Risk Factor;Eye;Fatty acid glycerol esters;fatty acid metabolism;Fatty Acids;Funding;Future;Genetic;Glucose;Glucosephosphates;Glycogen;glycogen metabolism;Glycolysis;Hepatocyte;Homeostasis;Hydrolysis;in vivo;inorganic phosphate;insight;Ion Pumps;Light;light intensity;Lipids;Liver;Measurement;Membrane;Metabolic;Metabolism;Methods;Mitochondria;Mus;Muscle;Muscle Cells;mutant;Mutation;Normal tissue morphology;Nucleotides;Nutrient;Organism;particle;Patients;Phagocytosis;Phagosomes;Phosphorylases;Phosphorylation;photoreceptor degeneration;Photoreceptors;Process;Proteins;Recycling;Research;Retina;Rhodopsin;Role;Signaling Molecule;Source;stress resilience;Structure of retinal pigment epithelium;Time;Tissues

PROJECT_TITLE: Control of Photoreceptor Metabolism

STUDY_SECTION: BDE

STUDY_SECTION_NAME: Biology and Development of the Eye Study Section[BDE]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: Chicago

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: Narrative The proposed research is relevant to public health because the development of a novel endogenous MRI method for quantitative imaging of metabolic function of adipose tissues will help to better understand the disrupted metabolic homeostasis in obesity and diabetes and to monitor responses of novel brown-fat targeting treatments. Thus, the proposed research is relevant to the part of NIH’s mission to enhance health, lengthen life, and reduce illness and disability.

PI_NAMEs: CAI, KEJIA  (contact)

PROGRAM_OFFICER_NAME: LAUGHLIN, MAREN R

PROJECT_TERMS: Adipocytes;Adipose tissue;Adrenergic Agents;Agonist;Amides;Animals;Bioenergetics;Brain;Brain Neoplasms;Brown Fat;cancer type;Cardiovascular Diseases;Cells;Chemicals;clinical translation;comorbidity;Contrast Media;Creatine;Creatine Kinase;Creatine Supplement;creatine transporter;design;Development;Diabetes Mellitus;Diagnosis;Diet;dietary;disability;Early Diagnosis;Energy Metabolism;Equilibrium;Fatty acid glycerol esters;fluorodeoxyglucose;Functional Imaging;Gene Modified;Health;Heart;High Fat Diet;Homeostasis;Human;Image;imaging modality;Impairment;improved;innovation;Insulin Resistance;Ionizing radiation;kinase inhibitor;Knock-out;Knockout Mice;Life;Life Style Modification;Magnetic Resonance Imaging;Malignant Neoplasms;Measurement;Measures;Mediator;Metabolic;Metabolic Diseases;metabolic imaging;Metabolism;Methods;Microdialysis;Mission;mitochondrial uncoupling protein;Molecular;molecular imaging;Monitor;Morphologic artifacts;Motion;Mus;Muscle;Non-Insulin-Dependent Diabetes Mellitus;novel;Obese Mice;Obesity;obesity treatment;Operative Surgical Procedures;Oral;Overweight;Persons;PET/CT scan;pharmacologic;prevent;Prevention;Protons;Public Health;quantitative imaging;Research;Resolution;Respiration;respiratory;response;Risk Factors;Rodent;Role;Route;Saline;Signal Transduction;spectrograph;success;Techniques;temporal measurement;Testing;Thermogenesis;Time;Tissue imaging;Tissues;uncoupling protein 1;United States National Institutes of Health;Validation

PROJECT_TITLE: Endogenous molecular MRI of creatine as a mediator of adrenergic activation of brown adipose tissue

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics;Nutrition

ORG_CITY: Newark

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: PROJECT NARRATIVE Proliferating cells reprogram metabolism to supply critical metabolites and satisfy the increased demand for specific nutrients. During early T cell development, the generation of T cell receptor diversity relies on robust synthesis of the TCR, which requires abundant nucleotides and hexosamines for proper synthesis and folding. Our studies will elucidate how the de novo hexosamine biosynthesis pathway reprogram metabolism via regulation of mTOR signaling and pyrimidine metabolism to generate a diverse TCR repertoire.

PI_NAMEs: JACINTO, ESTELA  (contact)

PROGRAM_OFFICER_NAME: BOND, MICHELLE RUEFFER

PROJECT_TERMS: Address;Affect;Anabolism;Biochemical;cationic antimicrobial protein CAP 37;Cell Count;Cell Differentiation process;Cell Physiology;Cell Proliferation;Cell surface;Cell Surface Receptors;Cells;Defect;Development;dietary manipulation;Dietary Supplementation;Enzymes;Equilibrium;Feedback;Flow Cytometry;FRAP1 gene;fructose-6-phosphate;Generations;Genes;Genetic;Genetic Recombination;Genomics;Glucosamine;Glutamine;glycosylation;Hexosamines;Immune system;immune system function;Impairment;in vivo;innovation;Isotopes;Link;Mass Spectrum Analysis;Messenger RNA;Metabolic Control;Metabolism;metabolomics;mouse model;mTOR inhibition;Nucleotides;Nutrient;Nutrient availability;Output;pathogen;Pathway interactions;Peptides;Process;Production;progenitor;programs;Protein Biosynthesis;protein folding;protein misfolding;Proteomics;Pyrimidine;pyrimidine metabolism;Regulation;Role;Signal Transduction;T-Cell Development;T-Cell Receptor;T-cell receptor repertoire;T-Lymphocyte;Techniques;Testing;thymocyte;Thymus Gland;Transcript

PROJECT_TITLE: The hexosamine biosynthesis pathway in metabolism and cell fate

STUDY_SECTION: CSRS

STUDY_SECTION_NAME: Cellular Signaling and Regulatory Systems Study Section[CSRS]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Nutrition;Osteoporosis

ORG_CITY: ROCHESTER

ORG_DEPT: ORTHOPEDICS

ORG_NAME: UNIVERSITY OF ROCHESTER

ORG_STATE: NY

PHR: Project Narrative The proposed research is relevant to public health because it has a potential to establish the role of osteoblast bioenergetic and redox processes in defining bone phenotype and provide a scientific basis for new therapeutic approaches for bone aging. It will also advance the field by elucidating yet unknown mechanisms connecting the unique metabolic setup in osteoblasts, i.e. mitochondrial/glycolysis/pentose phosphate axis with bone phenotype. This is highly relevant to the NIH mission of developing fundamental knowledge that will help to reduce the burdens of human aging and disability.

PI_NAMEs: ELISEEV, ROMAN  (contact)

PROGRAM_OFFICER_NAME: WILLIAMS, JOHN

PROJECT_TERMS: Abbreviations;aerobic glycolysis;Aging;Agreement;Alleles;Anabolism;Bioenergetics;bone;bone aging;bone health;bone loss;Bone Tissue;cancer cell;Cells;Citric Acid Cycle;Data;disability;DNA;Energy Metabolism;enzyme pathway;Enzymes;Equilibrium;Fatty Acids;G6PD gene;Glucose;glucose metabolism;Glutamates;Glutamine;Glycolysis;hallmarks of aging;Homeostasis;Human;Impairment;in vitro activity;in vivo;inhibitor;inorganic phosphate;Knock-in;Knowledge;Lactate Dehydrogenase;lactate dehydrogenase A;loss of function;Maintenance;Malate-Aspartate Shuttle Pathway;Measures;Mediating;Metabolic;Metabolism;metabolome;Mission;Mitochondria;mitochondrial dysfunction;Modeling;Mus;mutant;NADP;novel;novel therapeutic intervention;novel therapeutics;Nucleotides;old mice;osteoblast differentiation;osteoblast proliferation;Osteoblasts;Oxaloacetates;Oxidation-Reduction;Oxidative Phosphorylation;Oxidative Stress;Oxidoreductase;Pathway interactions;Pentosephosphate Pathway;Pentosephosphates;Phenotype;Process;progenitor;Proliferating;Public Health;Pyruvate;Reaction;Rejuvenation;repaired;Research;RNA Interference;RNA Precursors;Role;skeletal;Slice;Testing;Text;therapeutic target;Tissues;Transaminases;United States National Institutes of Health;Work

PROJECT_TITLE: Energy Metabolism in Osteoblasts and Bone Health

STUDY_SECTION: SBDD

STUDY_SECTION_NAME: Skeletal Biology Development and Disease Study Section[SBDD]


ADMINISTERING_IC: VA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: Veterans Affairs

ORG_CITY: OMAHA

ORG_NAME: OMAHA VA  MEDICAL CENTER

ORG_STATE: NE

PHR: Peripheral artery disease (PAD) is a cardiovascular disease manifesting from systemic atherosclerosis, which blocks the leg arteries and results in insufficient blood flow to the lower extremities. Limb ischemia from PAD is the most common disorder treated within the vascular surgery service at the Omaha Veterans’ Affairs Medical Center. PAD also accounts for one-third of the operations performed in the VA Medical Centers nationwide. This project aims to establish the feasibility and acceptability of a muscle oxygen-guided supervised exercise program for patients with PAD. We will determine the potential benefits of using this intervention over standard supervised exercise therapy. This modified intervention may enable patients to increase overall physical activity without the negative impacts on muscle structure and function. Increasing physical activity will decrease cardiovascular morbidity and mortality. If proven beneficial, our findings will lead to an improved exercise program that directly benefits veterans nationwide.

PI_NAMEs: PIPINOS, IRAKLIS ILIAS (contact)

PROJECT_TERMS: acceptability and feasibility;Activities of Daily Living;Acute;Adopted;Adverse effects;Affect;Antioxidants;Arteries;Atherosclerosis;Award;Biochemical;Biochemistry;Blood flow;Blood Vessels;Cardiovascular Diseases;cardiovascular risk factor;Cardiovascular system;Characteristics;claudication;Clinical Trials;comparison control;cost;Crossover Design;deoxyhemoglobin;Disease;effective therapy;Electron Spin Resonance Spectroscopy;Electronics;Enzyme-Linked Immunosorbent Assay;Exercise;exercise intensity;exercise physiologist;exercise program;Exercise Therapy;Exertion;experience;Fibrosis;functional independence;Gait;Goals;hemodynamics;Histologic;improved;improved mobility;Inflammation;Inflammatory;Intervention;Interview;Ischemia;Knowledge;Leg;limb ischemia;Lower Extremity;Measures;Medical center;Metabolic;Methods;Mitochondria;mitochondrial dysfunction;Monitor;Morbidity - disease rate;mortality;Muscle;muscle form;Muscle function;muscle strength;muscular structure;Myopathy;Near-Infrared Spectroscopy;operation;Outcome;Outcome Measure;Oxidative Stress;Oxygen;Oxyhemoglobin;Pain;Participant;Pathologic;Patient Care;Patients;Peripheral arterial disease;Peripheral Blood Mononuclear Cell;Physical activity;Pilot Projects;Positioning Attribute;preference;preservation;prevent;Procedures;Process;Production;programs;Proteins;Protocols documentation;Quality of life;Questionnaires;Randomized;Reactive Oxygen Species;Recommendation;Rehabilitation therapy;Reperfusion Therapy;Reporting;Research;response;Rest;sedentary lifestyle;Specific qualifier value;Surgeon;surgical service;Techniques;Tissues;Training;Treatment Efficacy;United States Department of Veterans Affairs;Veterans;Walking;walking performance;Western Blotting;Work

PROJECT_TITLE: Oxygen-guided supervised exercise therapy in peripheral artery disease.

STUDY_SECTION: RRDS

STUDY_SECTION_NAME: Rehabilitation Research and Development SPiRE Program[RRDS]


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Genetics

ORG_CITY: LEXINGTON

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: We recently found that high expression of the collagen-modifying enzyme lysyl hydroxylase 2 (LH2) drives lung cancer metastasis due to a previously undetected collagen glucosyltransferase (GGT) activity. Based on our new mechanistic and structural insights into LH2 GGT’s pro-metastatic activity, we hypothesize that the unique structural features of LH2 GGT underlie its pro-metastatic activity. If our hypothesis is proven true, these findings will inform LH2b GGT inhibitor development and could have broad clinical applicability because LH2 has been implicated in the metastasis of multiple cancer types.

PI_NAMEs: GUO, HOUFU  (contact)

PROGRAM_OFFICER_NAME: AMIN, ANOWARUL

PROJECT_TERMS: 2-Oxoglutarate 5-Dioxygenase Procollagen-Lysine;Active Sites;Address;Affinity;Alleles;Alternative Splicing;Anabolism;Binding;Binding Sites;Biological Assay;Cancer Biology;cancer cell;Cancer Etiology;cancer invasiveness;Cancer Patient;cancer type;Cells;Cessation of life;clinical application;Clustered Regularly Interspaced Short Palindromic Repeats;Collagen;Collagen Fibril;Country;Cysteine;Development;dimer;Dimerization;Disulfides;Enzymes;Epithelial Cells;Epithelium;Exons;Glucose;Glucosyltransferase;glycosylated collagen;Goals;Growth;Homologous Gene;Human;Hydrophobicity;Incidence;inhibitor;insight;interest;Kentucky;Knock-out;Laboratories;LHX2 gene;Link;Lung;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant Neoplasms;Mediating;Mesenchymal;Mesenchymal Cell Neoplasm;Modeling;mortality;mRNA Expression;Mus;mutant;Mutate;Mutation;Nature;Neoplasm Metastasis;new therapeutic target;Normal tissue morphology;novel;novel therapeutics;Osteoblasts;overexpression;Play;Prognosis;prognostic value;Protein Isoforms;Proteins;Reporting;Role;Sarcoma;Structure;Surface;Testing;therapeutic development;therapeutic target;Tissues;tumor;tumor progression;Tumor Promotion;Tumor-infiltrating immune cells;tumorigenesis;United States;Work

PROJECT_TITLE: Mechanistic and structural insights into a new pro-metastatic collagen glucosyltransferase

STUDY_SECTION: TEHM

STUDY_SECTION_NAME: Tumor Evolution, Heterogeneity and Metastasis Study Section[TEHM]


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;HPV and/or Cervical Cancer Vaccines;Immunization;Infectious Diseases;Pediatric;Prevention;Primary Health Care;Sexually Transmitted Infections;Social Determinants of Health;Vaccine Related

ORG_CITY: ATLANTA

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Suboptimal human papillomavirus (HPV) vaccine uptake has been an intractable problem since it was recommended for use in the US 12 years ago. Continued low uptake of HPV vaccine indicates that new systems-level approaches, beyond standard public health education campaigns, are needed to improve provider’s recommendations for HPV vaccination. We will utilize formative research to improve our existing TweenVax intervention, leading to an evaluation to assess the efficacy of the practice-, provider-, and patient/parent-level intervention package in improving HPV vaccine recommendations and uptake.

PI_NAMEs: BEDNARCZYK, ROBERT A. (contact)

PROGRAM_OFFICER_NAME: KOBRIN, SARAH

PROJECT_TERMS: 12 year old;13 year old;Academy;Address;Adolescent;adolescent health;adolescent patient;Affect;American;Appointments and Schedules;arm;Attention;Award;base;boys;Cancer Control;cancer prevention;Childhood;Clinic;Clinic Visits;Clinical;clinical examination;Clinical Trials;Cluster randomized trial;Communication;Continuing Education;Data;design;Development;Education;efficacy evaluation;Elements;Ethnography;Evaluation;evidence base;Family Physicians;Family Practice;Female Adolescents;follow-up;girls;health belief;Health Personnel;Healthcare;Healthy People 2020;HPV vaccine acceptance;Human papilloma virus infection;Human Papilloma Virus Vaccination;Human Papilloma Virus Vaccine;Human Papillomavirus;Immunization;Immunization Programs;implementation research;improved;Individual;Information Systems;Intervention;Interview;Male Adolescents;Malignant Neoplasms;Modeling;Online Systems;Parents;Patient Education;patient level intervention;Patients;Pediatrics;Phase;Pilot Projects;pilot test;Policies;prevent;programs;Provider;Public Health Education;Qualifying;Quantitative Evaluations;Randomized;Recommendation;Registries;Research;Research Project Grants;Series;Services;Severity of illness;Solid;standard of care;Standardization;System;Tablets;Tennessee;theories;therapy design;therapy development;three-arm trial;tool;Training;Training Activity;Treatment Efficacy;United States;Update;uptake;Vaccination;vaccine delivery;Vaccines

PROJECT_TITLE: TweenVax: A comprehensive practice-, provider-, and parent/patient-level intervention to improve adolescent HPV vaccination.


NIH_SPENDING_CATS: Biomedical Imaging;Clinical Research;Clinical Trials and Supportive Activities;Congenital Structural Anomalies;Kidney Disease;Orphan Drug;Pediatric;Polycystic Kidney Disease;Rare Diseases

ORG_CITY: CLEVELAND

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

ORG_STATE: OH

PHR: NARRATIVE Autosomal Recessive Polycystic Kidney Disease (ARPKD) is a potentially lethal inherited kidney disease affecting children and young adults. Unfortunately, methods to sensitively measure kidney disease progression are lacking creating a barrier to conducting clinical trials in these patients. In the proposed studies, our collaborative multi-center research team will evaluate the capability of our multiple MRI biomarkers of cystic burden, kidney perfusion, and fibrosis to: (1) sensitively detect and stage ARPKD kidney disease across the spectrum of disease (Aim 1); (2) assess the progression of kidney disease over time in comparison to conventional clinical measures of kidney function (Aim 2); and (3) develop new free-breathing MR Fingerprinting methods to pave the way for assessments of kidney disease in very young children with ARPKD (Aim 3).

PI_NAMEs: DELL, KATHERINE MACRAE (contact);FLASK, CHRISTOPHER A

PROGRAM_OFFICER_NAME: GOSSETT, DANIEL ROBERT

PROJECT_TERMS: 6 year old;advanced disease;Affect;Age;Animal Disease Models;arterial spin labeling;Autosomal Recessive Polycystic Kidney;autosome;Biological Markers;Breathing;burden of illness;Child;Chronic Kidney Failure;Clinic;Clinical;Clinical Trials;cohort;Collaborations;Conduct Clinical Trials;Cyst;Cystic kidney;Cystic Kidney Diseases;Data;Diffuse;Dilatation - action;Disease;Disease Management;Disease Progression;Early Diagnosis;Early identification;elastography;End stage renal failure;Fibrosis;Fingerprint;flasks;Functional disorder;Funding;Future;Genetic;Genetic Diseases;Glomerular Filtration Rate;Hereditary Disease;high risk;Hour;Human;Image;Infant;Inherited;Iohexol;Kidney;Kidney Diseases;kidney fibrosis;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Measurement;Measures;Methodology;Methods;Morbidity - disease rate;mortality;MRI Scans;multimodality;neonatal period;neonate;novel;novel therapeutics;Outcome Measure;participant enrollment;Pathology;patient subsets;Patients;Pediatric Hospitals;Perfusion;Philadelphia;potential biomarker;pre-clinical;progression risk;Progressive Disease;prospective;Publishing;Rare Diseases;recruit;Relaxation;Renal function;Reproducibility;Research;Rodent Model;Scanning;Sedation procedure;Severity of illness;Site;Survivors;Therapy Clinical Trials;Time;treatment response;United States National Institutes of Health;Universities;young adult

PROJECT_TITLE: Imaging Assessments of ARPKD Kidney Disease Progression

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


NIH_SPENDING_CATS: Aging;Biomedical Imaging;Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Prevention;Women's Health Research

ORG_CITY: SAINT LOUIS

ORG_DEPT: SURGERY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Mammographic breast density is one of the strongest risk factors for breast cancer. Notably, a reduction in breast density over time translates to a decrease in breast cancer incidence. However, because adult dietary and lifestyle modifications have not been shown to reduce mammographic density, identifying a pathway that can be targeted to reduce breast density and breast cancer incidence is crucial. Buidling on recent findings, we propose a clinical trial to quantify the effect of RANKL inhibition on mammographic density in high-risk premenopausal women with dense breasts. Study findings could open up additional approaches to primary breast cancer prevention in high-risk premenopausal women, who do not have dominant genetic predisposition.

PI_NAMEs: TORIOLA, ADETUNJI T (contact)

PROGRAM_OFFICER_NAME: HECKMAN-STODDARD, BRANDY

PROJECT_TERMS: Address;Adoption;Adult;Age Years;aged;Antibodies;arm;Biological Markers;biomarker signature;Blood;Breast;Breast biopsy;Breast Cancer Prevention;Breast Cancer Risk Factor;breast density;Cancer Center;Categories;Chemoprevention;Clinical;Clinical Trials;Computer software;Data;density;Development;Diet Modification;Dominant Genetic Conditions;Evaluation;Fibroblast Growth Factor;First Degree Relative;Future;Gene Expression;Genes;Genetic Predisposition to Disease;Goals;Health;high risk;Hospitals;Incidence;inclusion criteria;indexing;Injections;innovation;interest;International;Intervention;Intervention Studies;Life Style Modification;Ligands;Malignant Breast Neoplasm;Malignant Neoplasms;mammary;mammary epithelium;Mammary Gland Parenchyma;Mammographic Density;Mammographic screening;Mammography;Measures;Mediator;metabolome;Needles;Nuclear;parent grant;Participant;participant enrollment;Pathway interactions;Placebos;predicting response;predictive signature;Premenopause;Progesterone;Progesterone Receptors;Proliferating;Randomized;randomized, clinical trials;receptor;receptor expression;Receptor Inhibition;Recording of previous events;recruit;routine screening;screening;side effect;Signal Transduction;stem cells;Structure;study population;subcutaneous;Subcutaneous Injections;Susceptibility Gene;Tamoxifen;Target Populations;Testing;Therapeutic;Time;Transforming Growth Factors;Translating;treatment arm;ultrasound;Woman

PROJECT_TITLE: Targeting RANK Pathway in Mammographic Density and Primary Breast Cancer Prevention


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research;Rehabilitation

ORG_CITY: NEW YORK

ORG_DEPT: PSYCHIATRY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: In a clinical trial, 240 participants with mild cognitive impairment (MCI) across 4 U.S. academic sites will be randomized to computerized, web-based high dose crosswords (4 puzzles per week), low dose crosswords (1 puzzle per week), or a health education control group for 12 weeks with subsequent booster sessions for a total of 78 weeks. Efficacy will be compared on measures of cognition, function, and change in MRI volumetric measures with exploratory analyses for change in plasma biomarkers. If crosswords training shows efficacy and dose effects are clarified, it could become a low-cost, home-based, scalable, cognitive enhancement tool for individuals with MCI, which is a common condition and major public health problem worldwide.

PI_NAMEs: DEVANAND, DAVANGERE P (contact)

PROGRAM_OFFICER_NAME: HETTINGER, JANE CECELIA

PROJECT_TERMS: active control;Activities of Daily Living;Acute;Adult;age stratification;Alzheimer's Disease;Biological Markers;Blinded;cerebral atrophy;Clinical;clinical diagnosis;Clinical Trials;Cognition;Cognitive;cognitive enhancement;cognitive training;comparative efficacy;comparison control;computerized;Control Groups;cooperative study;cost;Dementia;Dose;epidemiology study;ethnic difference;Exercise;Frequencies;functional gain;functional outcomes;gender difference;Health education;Healthcare;Hippocampus;Home;Impaired cognition;Impairment;Individual;informant;instrument;instrumental activity of daily living;Intervention;Light;Literature;Magnetic Resonance Imaging;Measures;Mediator;Mental disorders;mild cognitive impairment;Modeling;Nerve Degeneration;neurofilament;Neuronal Plasticity;older adult;Online Systems;Outcome;Participant;patient engagement;Patient Recruitments;Patients;Persons;Phase;Plasma;pre-clinical;Prevention;primary outcome;progression risk;Public Health;Questionnaires;racial difference;Randomized;Reporting;Research Personnel;Risk;Sample Size;Sampling;secondary outcome;Severity of illness;Site;Therapeutic;Therapeutic Intervention;Thick;tool;Training;treatment effect;treatment group;trend;Universities;Video Games;Washington;web platform;week trial

PROJECT_TITLE: COGNITIVE TRAINING AND NEUROPLASTICITY IN MILD COGNITIVE IMPAIRMENT

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Aging;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Osteoporosis;Physical Injury - Accidents and Adverse Effects;Prevention;Racial and Ethnic Minority Health Research;Women's Health Research

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: We will test the global hypothesis that external bone size is associated with variation in hip strength-decline trajectory and fracture risk, independent of femoral neck aBMD. We leverage high resolution imaging and direct mechanical tests of cadaveric proximal femurs along with longitudinal hip DXA images collected for older men and women enrolled in MrOS and Health ABC to identify structural and material measures that explain the external-size specific fracture risks in terms of structural traits and trait interactions. Successful completion of the proposed aims will provide evidence of multiple biomechanical pathways leading to reduced proximal femur strength in older men and women and will identify sets of traits that best predict fracture risk for subgroups of individuals.

PI_NAMEs: BREDBENNER, TODD L;JEPSEN, KARL J (contact)

PROGRAM_OFFICER_NAME: NICKS, KRISTY

PROJECT_TERMS: Address;Age;age related;age related decline;Area;Biomechanics;black men;Black Populations;black women;bone;Bone Density;Bone Mineral Contents;bone strength;Cadaver;Clinical;cohort;computer framework;cortical bone;Data;Disease;Dual-Energy X-Ray Absorptiometry;early detection biomarkers;Early identification;Elderly;Enrollment;Ethnic Origin;Femur;Fracture;fracture risk;fragility fracture;Health;high resolution imaging;Hip Fractures;Hip region structure;Image;improved;Individual;Longitudinal Studies;Maintenance;male;Measures;Mechanics;men;Midlife women;Modeling;Monitor;Neck;novel;novel strategies;older men;Older Population;older women;Osteoporosis;osteoporosis with pathological fracture;Osteoporotic;Outcome;Pathway interactions;Pattern;Population;Population Heterogeneity;prevent;Prevention strategy;Preventive treatment;Public Health;Race;Risk;risk prediction;sex;Shapes;skeletal;Sorting;Structure;Structure-Activity Relationship;Subgroup;substantia spongiosa;Testing;Time;trait;Uncertainty;Variant;Voice;White Women;Woman;Work;World Health Organization

PROJECT_TITLE: Heterogeneous pathways to bone strength decline and hip fracture

STUDY_SECTION: MRS

STUDY_SECTION_NAME: Musculoskeletal Rehabilitation Sciences Study Section[MRS]


ED_INST_TYPE: HOSPITALS

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Cancer;Neurosciences

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: PROJECT NARRATIVE The nervous system drives the initiation and growth of many cancers, establishing the targeting of nervous system-cancer interactions as a new therapeutic approach in oncology. To spur pioneering interactions among researchers in the fields of clinical oncology, cancer biology, and neuroscience, the proposed Cancer Neuroscience: An Emerging Hallmark symposium will feature seminars by a diverse team of leading experts in cancer neuroscience, with topics ranging from translational and basic biology to oncology, mental health, and quality of life issues for cancer survivors. The primary goal of the symposia will help fulfill the mission of the NCI of advancing scientific knowledge and help cancer patients have longer and healthier lives by exchanging data and driving thought-provoking discussions on the nervous system as a new actionable target in cancer treatment by a diverse forum of investigators and trainees.

PI_NAMEs: AMIT, MORAN  (contact);MONTANO, MONTY A

PROGRAM_OFFICER_NAME: GEORGE, CHRISTINA DAWN

PROJECT_TERMS: Acceleration;Advanced Malignant Neoplasm;Advocate;Affect;Age;Anatomy;anti-cancer research;Area;arm;Automobile Driving;bench to bedside;Biology;Biology of Aging;Brain;brain health;Cancer Biology;cancer cell;Cancer Center;Cancer Patient;Cancer Survivor;cancer therapy;career;career development;Cells;Central Nervous System;Clinical Oncology;clinically relevant;Collaborations;Committee Members;Communication;Communities;Country;Data;data exchange;detection platform;Development;Discipline;disparity reduction;diversity and inclusion;Environment;Ethnic Origin;Evaluation;Faculty;Fertilization;Fostering;Friends;frontier;Funding;Future;Gender;Gender Identity;Geography;Goals;Growth;Hybrids;Immune;Immune system;Immunologist;Immunooncology;improved;Individual;Institution;Integrative Medicine;International;Invaded;Investigation;Journals;Knowledge;lectures;Location;Malignant Neoplasms;meetings;Mental Health;Mentorship;Methodology;Mission;Neoplasm Metastasis;Nerve;Nerve Fibers;nerve injury;Nervous System;Nervous System Physiology;Neurobiology;Neuroepithelial, Perineurial, and Schwann Cell Neoplasm;neurogenesis;Neuroglia;Neuroimmune;Neurologist;Neuronal Plasticity;Neurons;neuroregulation;Neurosciences;Neurosciences Research;novel therapeutic intervention;Oncologist;Oncology;Outcome;Pain;Palliative Care;Participant;Patient advocacy;Patient Care;Patient-Focused Outcomes;Patients;perineural;Peripheral Nervous System;Play;Policies;Postdoctoral Fellow;programs;Quality of life;Race;recruit;Religion;Research;Research Personnel;Role;Scientific Advances and Accomplishments;Scientist;Secure;Series;Services;sex;Sex Orientation;Site;Socioeconomic Status;Specialist;Students;Surgeon;survival outcome;symposium;Translating;transmission process;Travel;treatment strategy;tumor;tumor initiation;tumor microenvironment;tumor progression;Tumor Promotion;Underrepresented Populations;United States National Institutes of Health;University of Texas M D Anderson Cancer Center;virtual;Work;Writing

PROJECT_TITLE: Cancer Neuroscience - An Emerging Hallmark

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 PCRB-9 (O1)]


ORG_CITY: PHILADELPHIA

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE The proposed research program utilizes a systematic approach to investigate new genetic discoveries associated with blood lipids and cardiovascular disease (CVD). The investigators aim to demonstrate this through a paradigm of functional characterization of newly discovered lipid-regulating genes using naturally-occurring genetic variants. This effort will help bridge the significant gaps in knowledge linking human genomic discoveries to new biology and therapeutic targets and provide a roadmap for how novel genomic loci, genes, and variants associated with blood lipids and CVD might be investigated in a systematic manner.

PI_NAMEs: RADER, DANIEL JAMES (contact)

PROGRAM_OFFICER_NAME: HASAN, AHMED A  K

PROJECT_TERMS: Abdominal Aortic Aneurysm;Aortic Valve Stenosis;Atherosclerosis;Biological;Biological Models;Biology;blood lipid;Cardiovascular Diseases;causal variant;Cells;Code;Communities;comparative;Data;Data Analyses;data ingestion;Disease;Genes;Genetic;genetic association;genetic variant;genome wide association study;genomic data;genomic locus;Genomics;Goals;Human;Human body;Human Genetics;insight;Investigation;Knowledge;Link;lipid metabolism;Lipids;Lipoproteins;Liver;Low-Density Lipoproteins;Medical;Metabolism;Molecular;mouse model;National Heart, Lung, and Blood Institute;novel;Outcome Study;Pathogenesis;Peripheral arterial disease;Phenotype;Physiological;Plasma;Privatization;programs;Property;Proteins;Research;Research Personnel;Risk;Risk Factors;Risk Reduction;Role;Structure;Structure-Activity Relationship;therapeutic target;trait;Variant

PROJECT_TITLE: From genetic association to function: pleiotropic novel genes and variants linking lipid metabolism and cardiovascular diseases

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-I (O1)]


NIH_SPENDING_CATS: Burden of Illness;Cancer;Clinical Research;Comparative Effectiveness Research;Cost Effectiveness Research;Health Services;Orphan Drug;Patient Safety;Precision Medicine;Rare Diseases

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: Project Narrative One-third of the U.S. population has a detectable thyroid nodule and thyroid cancer is increasing in incidence and prevalence; yet the effects of current and emerging clinical practice on patients and related health care utilization are unknown. The proposed comprehensive simulation model of individuals with benign and malignant thyroid nodules in the U.S. population is a powerful, systematic approach to evaluating the impact of recent changes in practice guidelines and future advancements in the diagnosis, treatment, and surveillance strategies on patients with thyroid nodules and cancer. The insights gained through the proposed aims will identify strategies that have the most promise for increasing both length and quality of life, while enhancing the health and minimizing harm to our patients.

PI_NAMEs: CUNNINGHAM, CARRIE ELIZABETH (contact)

PROGRAM_OFFICER_NAME: MCKEE, TAWNYA C

PROJECT_TERMS: Affect;American;Area;Benign;Biopsy;BRAF gene;Calcitonin;Calibration;cancer subtypes;Carcinoma;Caring;Clinical;clinical practice;Clinical stratification;comparative cost effectiveness;Computer Models;Conduct Clinical Trials;Consumption;cost;cost effective;Cost utility;Data;data registry;Databases;Development;Diagnosis;diagnostic biomarker;diagnostic strategy;diagnostic technologies;Disease;Disease Reservoirs;Economics;Effectiveness;effectiveness evaluation;Evaluation;Fine needle aspiration biopsy;Frequencies;Future;Goals;Guidelines;Harm Reduction;Health;Health Care Costs;health care service utilization;health related quality of life;Health Resources;improved;improved outcome;Incidence;Individual;individual patient;Indolent;insight;Interdisciplinary Study;Intervention;Length;Lobectomy;Localized Disease;Malignant - descriptor;Malignant neoplasm of thyroid;Malignant Neoplasms;mathematical model;Mathematics;Medical;medullary thyroid carcinoma;Minority;Modeling;models and simulation;Molecular;Molecular Diagnostic Testing;molecular diagnostics;Morbidity - disease rate;mortality;multidisciplinary;Natural History;neoplasm registry;Nodule;online version;Operative Surgical Procedures;Outcome;overtreatment;Papillary;Papillary thyroid carcinoma;Patient Care;Patient-Focused Outcomes;Patients;personalized approach;personalized medicine;personalized strategies;Population;Practice Guidelines;pre-clinical;predictive marker;Prevalence;Prospective Studies;Public Health;Quality of Care;Quality of life;Recurrent disease;Reporting;Research;Research Personnel;research study;Risk;risk stratification;Scientist;screening;Serum;surveillance strategy;Technology;Testing;Thyroid Diseases;Thyroid Gland;Thyroid Nodule;Thyroidectomy;Time;treatment optimization;treatment strategy;Tumor Subtype;Uncertainty;Visualization;Work

PROJECT_TITLE: Thyroid Nodule Treatment Optimization: A Personalized Approach


ORG_CITY: BRONX

ORG_NAME: JAMES J PETERS VA  MEDICAL CENTER

PHR: Project Narrative Diabetic kidney disease (DKD) and focal segmental glomerulosclerosis (FSGS) are common cause of end- stage kidney disease (ESKD) in the US and in our veterans. However, current regimen provides only partial therapeutic effects and the incidence and prevalence of these diseases remains high. Therefore, it is urgently needed to develop novel preventive and therapeutic measures for patients with DKD and FSGS.

PI_NAMEs: HE, JOHN CIJIANG (contact)

PROJECT_TERMS: Acceleration;Adriamycin PFS;Agonist;Animal Model;Attenuated;Binding;Binding Proteins;Biological;Biological Assay;C10;Cell Survival;Data;db/db mouse;design;diabetic;Diabetic Nephropathy;Disease;dosage;Dose;drug development;drug discovery;Drug Kinetics;drug metabolism;End stage renal failure;Event;experimental analysis;Experimental Models;Family;Focal and Segmental Glomerulosclerosis;Foot Process;Gene Expression;Goals;Grant;Homology Modeling;Human;improved;In Vitro;in vivo;Incidence;Inflammation;Injury;insight;Investigational New Drug Application;Kidney;Kidney Diseases;Knock-out;Knockout Mice;Lead;lead optimization;Legal patent;Measures;Mediating;Modeling;mRNA Expression;Mus;Nephrectomy;NF-kappa B;novel;novel therapeutics;Obese Mice;Paper;Pathway interactions;Patients;peptidomimetics;Pharmaceutical Preparations;Phosphorylation;podocyte;Prevalence;Preventive;prognostic;Property;Protective Agents;protective effect;protective pathway;Protein S;Proteinuria;Proteomics;Proto-Oncogene Proteins c-akt;Publications;Publishing;receptor;Receptor Protein-Tyrosine Kinases;Regimen;Regulation;Renal glomerular disease;Reporting;Role;screening;Series;Signal Transduction;Site;small molecule;Specificity;Structure;success;Systems Biology;targeted treatment;Therapeutic;Therapeutic Effect;Toxic effect;transcriptomics;Translations;TYRO3 gene;Tyrosine;Validation;Veterans

PROJECT_TITLE: Lead optimization of Tyro3 agonists as a novel therapy for glomerular disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 NEPH-N (01)]


ADMINISTERING_IC: EB

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Biomedical Imaging;Breast Cancer;Cancer;Women's Health Research

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: GEORGIA INSTITUTE OF TECHNOLOGY

PHR: Project Narrative Noninvasive tracking of macrophage trafficking can reveal important molecular, cellular, and functional characteristics of the host tissue and support the discovery of new biomarkers for improved diagnosis, prognosis, and treatment monitoring. This proposal will lay the groundwork towards the development of a novel framework for macrophage imaging and tracking using ultrasound.

PI_NAMEs: ARVANITIS, KONSTANTINOS-COSTAS  (contact)

PROGRAM_OFFICER_NAME: ATANASIJEVIC, TATJANA

PROJECT_TERMS: 4T1;Address;Animals;Atherosclerosis;Autoimmune;Biological Markers;Bone Marrow;Cancer Detection;cancer immunotherapy;Cell Count;Cell Line;Cells;Characteristics;clinical translation;Collagen;contrast imaging;cost;Data;Definity;density;Detection;detection limit;Development;Diagnosis;Diagnostic;Disease;experimental study;Flow Cytometry;Homeostasis;Homing;Host Defense;Hour;human disease;Image;imaging modality;Immune;Immunofluorescence Immunologic;improved;In Vitro;in vivo;Inbred BALB C Mice;indexing;Insulin-Dependent Diabetes Mellitus;Investigation;Label;Liver;Macrophage;Magnetic Resonance Imaging;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Neoplasms;Measures;Mechanics;Methods;Microbubbles;Microbubbles Ultrasound Contrast Medium;Microscopy;migration;Modality;Modeling;Molecular;Monitor;monocyte;mouse model;Mouse Strains;Mus;Noise;novel;Optics;Organ;Outpatients;pathogen;Pattern;Penetration;Performance;Physiologic pulse;Play;portability;Positron-Emission Tomography;prevent;Prognosis;prognostic;Prognostic Marker;Research;Resolution;Rodent;Role;Signal Transduction;Site;Solid Neoplasm;Specificity;Technology;Testing;Therapeutic Intervention;Time;Tissues;trafficking;tumor;Ultrasonography;ultrasound

PROJECT_TITLE: Imaging of macrophage trafficking with ultrasound


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: MINNEAPOLIS

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE Millions of people in the U.S. and worldwide have been diagnosed with Parkinson’s disease (PD), a progressively debilitating disorder characterized by slowed and abnormal movement. Many patients with PD who no longer respond adequately to medications can be treated successfully with an FDA approved therapy known as deep brain stimulation (DBS), however results vary widely among individual patients and much remains unknown about how it works. Results from this study will provide a better understanding of how DBS and medical therapy change brain function to improve movement in patients, and lead to the refinement of current approaches and the development of new DBS strategies that provide a more consistent and beneficial therapeutic effect.

PI_NAMEs: VITEK, JERROLD L (contact)

PROGRAM_OFFICER_NAME: SIEBER, BETH-ANNE

PROJECT_TERMS: Address;Affect;Anatomy;Animals;Area;Basal Ganglia;Behavioral;Biological Markers;Brain;Clinical;Coupling;Data;Deep Brain Stimulation;Development;Diagnosis;Disease;Dyskinetic syndrome;effective therapy;FDA approved;Frequencies;Functional disorder;Future;Globus Pallidus;Implant;improved;Individual;individual patient;insight;Knowledge;Levodopa;Mediating;Medical;Mental disorders;Modeling;Motor;Motor Cortex;Motor Pathways;Movement;Movement Disorder Society Unified Parkinson's Disease Rating Scale;Nervous System Disorder;Neurons;nonhuman primate;novel;Outcome;Parkinson Disease;Parkinsonian Disorders;Pathway interactions;Patients;Pattern;Persons;Pharmaceutical Preparations;Phase;Physiologic pulse;Population;Prefrontal Cortex;Reporting;Role;Severities;Site;STN stimulation;Structure;Structure of subthalamic nucleus;Testing;Thalamic structure;Therapeutic;Therapeutic Effect;Therapeutic Intervention;therapy development;Time;Work

PROJECT_TITLE: Basal Ganglia Cortical Coupling and Connectivity Changes in PD and DBS

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Mental Health;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Prevention;Social Determinants of Health

ORG_NAME: MAYO CLINIC ROCHESTER

PHR: PROJECT NARRATIVE / LAY SUMMARY There is a critical need to develop and validate tools to assess cognitive function remotely (e.g., not in a clinical facility) for both research and clinical purposes. Mayo Test Drive is an easily accessible, web-based platform and brief cognitive screening instrument developed for remote self-administered cognitive assessment via multiple devices (e.g., smartphones, PCs, tablets) to ensure widespread utility in urban or rural environments. This project is relevant to the NIA's mission and will specifically (1) improve our understanding of the aging brain, Alzheimer's disease, and other neurodegenerative diseases and (2) promote broad use and dissemination of digital technology for early detection and monitoring of cognitive decline in aging, Alzheimer's disease and AD-related dementias.

PI_NAMEs: STRICKER, NIKKI H (contact)

PROGRAM_OFFICER_NAME: LUO, YUAN

PROJECT_TERMS: Address;Aging;aging brain;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease related dementia;Amyloid;Amyloid beta-42;Area;Assessment tool;Behavior Therapy;Biological;Biological Markers;Biology;Cellular Phone;Clinic;Clinical;clinical practice;clinical translation;Clinical Trials;Cognitive;cognitive function;cognitive testing;cohort;computerized;Computers;Dementia;demographics;Development;Devices;diagnostic accuracy;digital;digital technology;Early Diagnosis;Early Intervention;Ensure;executive function;flexibility;follow-up;Funding;Future;Glial Fibrillary Acidic Protein;Goals;Impaired cognition;improved;Individual;instrument;Learning;Machine Learning;Measures;Medical center;medical specialties;Memory;Memory impairment;Methods;mild cognitive impairment;Mission;Mississippi;Monitor;Needs Assessment;neurodegenerative dementia;Neurodegenerative Disorders;Neuropsychology;novel;older adult;open source;Participant;Pathologic;Pattern;Performance;Persons;Plasma;Positron-Emission Tomography;pre-clinical;Predictive Value;Preparation;processing speed;prodromal Alzheimer's disease;recruit;remote administration;remote assessment;Reporting;Research;rural environment;screening;Self Administration;social determinants;Specificity;structural health determinants;Symptoms;Syndrome;Tablets;tau Proteins;Testing;tool;Triage;Universities;urban setting;Validation;Visit;Visual;web platform

PROJECT_TITLE: Validation of the Mayo Test Drive Screening Battery Composite and Stricker Learning Span for Early Detection and Monitoring of Cognitive Decline in Preclinical and Prodromal Alzheimer’s Disease


ORG_CITY: SAN DIEGO

ORG_NAME: VA SAN DIEGO HEALTHCARE SYSTEM

PHR: Alcohol use disorder (AUD) is highly prevalent in Veterans, and while evidence-based treatments (EBT) are effective at reducing alcohol use, the rate of relapse if high. Anhedonia, i.e., a reduced interest in rewards, is widespread in Veterans, contributes to the maintenance of maladaptive alcohol use, and predicts poorer treatment outcomes. However, anhedonia is a multi-faceted deficit involving several mechanisms of goal- directed reward behavior, which are still poorly understood in relation to alcohol use and AUD outcomes. The proposed research will use computational modeling and functional neuroimaging to identify mechanistically driven anhedonic markers of alcohol recovery in Veterans with AUD completing standard care EBT. This project is expected to improve our understanding of how the relationships between anhedonia and alcohol use impact AUD recovery in Veterans, and to identify understudied mechanisms of change that are critical for developing new interventions to boost healthy reward processing in Veterans.

PI_NAMEs: HARLE, KATIA  (contact)

PROJECT_TERMS: Address;Aftercare;alcohol abuse therapy;Alcohol consumption;alcohol cue;alcohol reinforcement;alcohol use disorder;Alcohols;Anhedonia;Anterior;approach behavior;arm;Bayesian Analysis;Bayesian learning;Bayesian Modeling;Behavior;Behavioral;Behavioral Mechanisms;Brain;cingulate cortex;Clinical assessments;clinical predictors;Clinical Trials;cognitive process;Cognitive Therapy;Computer Models;computerized;Computers;Corpus striatum structure;Development;drinking;drinking behavior;Dropout;Enrollment;evidence base;Evidence based treatment;expectation;Funding;Goals;Heavy Drinking;improved;Individual;insight;interest;Intervention;Learning;Maintenance;Measures;Medial;Mental Depression;Methods;Modeling;Moods;neural;neurobehavioral;Neurobiology;neuroimaging;Outcome;Participant;Pathology;Patients;Post-Traumatic Stress Disorders;predict clinical outcome;Prefrontal Cortex;Probability;Protocols documentation;Psychiatric therapeutic procedure;Randomized;Recovery;recruit;reduced alcohol use;Relapse;Research;response;reward circuitry;reward processing;Rewards;Role;Severities;Social Conditions;standard care;Substance Addiction;substance use;Symptoms;System;targeted treatment;tool;Training;Treatment outcome;treatment response;Triage;Veterans

PROJECT_TITLE: The Neurocomputational mechanisms of anhedonia and their role in predicting alcohol use and treatment responsiveness in Veterans with Alcohol Use Disorder"

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 NURA-N (01)]


ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Heart attack and stroke due to blood clots in the blood vessels are a primary cause of morbidity/mortality in the older individuals, which is enhanced by risk factors such as diabetes. We will investigate cause of blood clot formation in aged mice and in the mouse with diabetes. We will study if and how calorie restriction protects from age-related blood clot formation.

PI_NAMEs: DAYAL, SANJANA  (contact)

PROGRAM_OFFICER_NAME: LOUDEN, ANDREW

PROJECT_TERMS: Adhesions;Age;age related;age related changes;Age related comorbidities;aged;Aging;aging related;Agonist;Biological Assay;Blood coagulation;Blood Platelets;Blood Vessels;Caloric Restriction;Cardiolipins;Carotid Artery Thrombosis;cell free DNA;Circulation;Clinical Research;Coagulation Process;cohort;comorbidity;Cytoplasmic Granules;Data;Deacetylase;Deep Vein Thrombosis;demographics;Diabetes Mellitus;diabetic;DNA;Dose;Down-Regulation;druggable target;Eating;Elderly;Event;Generations;Goals;Healthcare;healthy lifestyle;High Fat Diet;high risk population;honokiol;Human;Hyperactivity;in vivo;Incubated;Inferior vena cava structure;Insulin Resistance;Intervention;lifestyle intervention;Ligation;Link;Measures;Mediating;mimetics;Mitochondria;Mitochondrial DNA;Mitochondrial Proteins;Modeling;Molecular Target;Morbidity - disease rate;mortality;Mus;Myocardial Infarction;new therapeutic target;Non-Insulin-Dependent Diabetes Mellitus;novel;Nuclear;Obesity;old mice;Older Population;Oxidants;Pathway interactions;pharmacologic;Phenotype;Pilot Projects;Plasma;Platelet Activation;Population;Predisposition;prevent;Preventive;Preventive measure;protective effect;Proteins;Reactive Oxygen Species;Regulation;Reporting;Risk Factors;Role;Serine;Signal Transduction;Sirtuins;small molecule;SOD2 gene;Stenosis;Streptozocin;Stroke;Superoxide Dismutase;Surface;targeted treatment;Testing;therapy development;Thrombin;Thrombosis;thrombotic;translational applications;translational approach;Venous Thrombosis

PROJECT_TITLE: Preventive mechanisms of Age-associated Thrombosis

STUDY_SECTION: HTBT

STUDY_SECTION_NAME: Hemostasis, Thrombosis, Blood Cells and Transfusion Study Section[HTBT]


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Heart Disease;Networking and Information Technology R&D (NITRD);Nutrition;Physical Activity;Physical Rehabilitation;Prevention;Rehabilitation;Telehealth

ORG_DEPT: MISCELLANEOUS

PHR: Narrative Cardiac rehabilitation (CR) is effective at improving cardiovascular outcomes by supporting heart-healthy lifestyle changes, but these benefits are often not sustained after patients finish the program. Mobile health (mHealth) has the potential to provide ongoing support for behavioral maintenance after CR programs end, but to do so effectively, there is a need for new approaches to support engagement with mHealth interventions. We will develop algorithms and user interfaces that enable mHealth interventions to effectively adapt to a broad range of changes in individuals' lives so they can continue to be useful—and effectively support behavior change—over the long-term.

PI_NAMEs: KLASNJA, PREDRAG  (contact)

PROGRAM_OFFICER_NAME: CAMPO, REBECCA A

PROJECT_TERMS: adaptation algorithm;Address;Adopted;Algorithms;arm;Award;Behavior;behavior change;Behavioral;Behavioral Mechanisms;behavioral outcome;Cardiac rehabilitation;cardiovascular risk factor;Cardiovascular system;Climacteric;comparison intervention;Data;Decision Making;design;Development;Eating;Effectiveness;Effectiveness of Interventions;Elements;Event;Exercise;exercise intervention;Family;Feedback;fitbit;Frustration;Funding;General Population;Generations;Goals;good diet;Health;Health behavior;Healthy Eating;healthy lifestyle;Heart;Heart Diseases;hospital readmission;improved;Individual;Information Systems;innovation;Intervention;intervention effect;Left;Length;Life;Longitudinal Studies;Maintenance;Measures;Mediating;Methods;mHealth;mhealth interventions;middle age;Mobile Health Application;Monitor;mortality;novel;novel strategies;older adult;Outcome;Patient Abandonment;Patients;Perception;Persons;Physical activity;programs;randomized trial;Randomized, Controlled Trials;recidivism;Research;Risk Reduction;satisfaction;Science;Specific qualifier value;System;Travel;treatment arm;trial design;Trust;uptake;Work

PROJECT_TITLE: ADAPT: Enabling robust adaptation in mHealth interventions for supporting maintenance of heart-healthy behaviors

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 HSS-F (90)]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Disorders;Down Syndrome;Intellectual and Developmental Disabilities (IDD);Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

PHR: Project Narrative Abnormal brain development in DS begins in utero. It is critical to be aware of an altered initial brain anatomy in DS for better predicting what aspects of brain function will likely preferentially/precociously deteriorate, which would allow for potentially earlier/better prevention and treatment. Based on our promising results from in vivo MRI, we plan to confirm the findings using ex vivo MRI with significantly higher spatial resolution as well as polarization sensitive optical coherence tomography which provides micron-level spatial resolution, in order to identify detailed basis of the DS early brain abnormality.

PI_NAMEs: TAKAHASHI (OKI), EMI  (contact)

PROGRAM_OFFICER_NAME: BARDHAN, SUJATA

PROJECT_TERMS: Address;Age;Agreement;Anatomy;Awareness;Axon;Biological;Birth;Brain;brain abnormalities;brain based;brain malformation;brain morphology;Brodmann's area;Cerebral cortex;Clinical;clinical translation;Cognitive deficits;Congenital chromosomal disease;Data;Destinations;Deterioration;Development;Diffusion Magnetic Resonance Imaging;Down's Syndrome;Early Diagnosis;Early identification;Epigenetic Process;Etiology;fetal;Fiber;Funding;Future;Heterogeneity;Histologic;Histopathology;immunohistochemical markers;Immunohistochemistry;Impairment;in utero;in vivo;in vivo imaging;Infant;Knowledge;Language;Learning;Letters;Life;Link;Magnetic Resonance Imaging;Measures;Memory;migration;Morphology;nerve stem cell;Neurobiology;Neurodevelopmental Impairment;neurofilament;neuroimaging;Neurons;Newborn Infant;Optical Coherence Tomography;Outcome;Parietal;Parietal Lobe;Pathologic;pathological aging;Pathology;Pathway interactions;Pattern;Phase;phenotypic data;Physiological;postnatal;Pregnancy;Premature aging syndrome;Premature Infant;Prevention;prospective;Radial;Recording of previous events;Reporting;Resolution;Retrospective Studies;Science;Sensory;Severities;somatosensory;spatiotemporal;Speech;Stains;statistics;stem cell population;Stream;subventricular zone;Superior temporal gyrus;Symptoms;Techniques;Temporal Lobe;Term Birth;Thick;Thinness;Toddler;tractography;United States;Ventricular

PROJECT_TITLE: Brain Development in Down Syndrome during Fetal and Early Postnatal Ages

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 DBD-M (90)]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Eye Disease and Disorders of Vision;Mental Health;Mental Illness;Neurosciences;Schizophrenia;Serious Mental Illness

PHR: Narrative Transcranial electrical stimulation represents a promising approach for treatment of cognitive dysfunction in schizophrenia and other mental disorders. This project will provide early-stage testing of transcranial interference stimulation as a promising new transcranial electrical stimulation approach.

PI_NAMEs: JAVITT, DANIEL C. (contact);JUCHEM, CHRISTOPH ;SEHATPOUR, PEJMAN

PROGRAM_OFFICER_NAME: ANKUDOWICH, ELIZABETH

PROJECT_TERMS: Affective;Aftercare;Alzheimer's Disease;autism spectrum disorder;Behavioral;Brain;Canada;Cell Nucleus;Cephalic;China;Clinical;clinically relevant;Cognitive deficits;cognitive function;cohort;Complement;Consultations;Controlled Study;Corpus striatum structure;Data;Deep Brain Stimulation;design;Development;Devices;Disease;Dose;Double-Blind Method;Effectiveness;Electric Stimulation;Electroencephalography;Emotions;Event;Face;Face Processing;Facial Expression;first-in-human;Frequencies;Functional disorder;Functional Magnetic Resonance Imaging;functional magnetic resonance imaging/electroencephalography;Funding;Future;Generations;Genetic Complementation Test;Goals;healthy volunteer;Impaired cognition;Impairment;improved;Individual;industry partner;Investigational Drugs;Link;Location;Magnetic Resonance Spectroscopy;Measures;Mediating;Medical;Mental disorders;minimal risk;Modeling;National Institute of Mental Health;Neurocognition;Neurocognitive;Neurocognitive Deficit;neurophysiology;neuropsychiatric disorder;new technology;noninvasive brain stimulation;novel;Pattern;Performance;Periodicity;Phase I Clinical Trials;Physiological;Play;Process;Protons;Publications;Pulvinar structure;Randomized;Reporting;Research;Research Project Grants;response;Rest;Risk;Role;Safety;safety assessment;Schizophrenia;Sensory;social;social cognition;Specificity;Stimulus;Structure;System;Techniques;Technology;Testing;Thalamic structure;Tissues;tool;Visual;Visual Cortex;Visual impairment;visual processing

PROJECT_TITLE: Use of alpha-frequency deep transcranial interference stimulation (tIS) to understand and modify temporal dynamics of face emotion recognition and social/affective function.

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-B (01)]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Depression;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Serious Mental Illness

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Narrative Many antidepressants show limited effectiveness in patients, which partially reflects the limited relevance of the models used to study depression-relevant behavior in animals to the human condition. The proposed study will test whether psychedelic drugs, such as psilocybin, can reverse the effects of three distinct manipulations known to induce depression-relevant behaviors in mice. Using both behavioral and EEG assessments, we intend to develop more suitable depression-relevant models and to find new, and possibly more effective, treatments for people with depression.

PI_NAMEs: HALBERSTADT, ADAM L.;YOUNG, JARED WILLIAM (contact)

PROGRAM_OFFICER_NAME: HUPALO, SOFIYA

PROJECT_TERMS: Acetylcholinesterase Inhibitors;Acute;Affect;Anhedonia;Animals;anti-depressive agents;Attenuated;Awareness;Behavior;behavior measurement;behavior test;Behavioral;Behavioral Model;Belief;Biological;Biological Markers;Chronic;Clinic;Clinical;clinical efficacy;Clinical Sensitivity;Clinical Trials;conventional therapy;Coping Skills;Corticosterone;Data;Depressed mood;depressive symptoms;Development;Disease;Dose;Effectiveness;efficacy evaluation;Electroencephalography;Exhibits;Face;Female;Food;forced swim test;Future;Hallucinogens;Head;Heterogeneity;Human;Immobilization;Impairment;Intoxication;Ketamine;Laboratories;Link;Major Depressive Disorder;male;Mental Depression;Mental disorders;Modeling;Morbidity - disease rate;mortality;Mus;Nature;neural;Neurobiology;Neurologic Process;neuronal circuitry;novel;Outcome;Outcome Measure;Parietal;patient population;Patients;Performance;Persons;Pharmaceutical Preparations;pharmacologic;Pharmacotherapy;Photoperiod;Physostigmine;Population;preference;Process;Property;Psilocybin;reduce symptoms;remediation;Resistance;response;Reversal Learning;Rewards;Rodent;Seasonal Affective Disorder;sex;stressor;Sucrose;Symptoms;Taxonomy;Testing;Therapeutic;therapy development;therapy resistant;Time;Translations;Treatment Efficacy

PROJECT_TITLE: Determining the efficacy of psychedelic agents reversing depression-relevant amotivated behaviors with concomittant EEG biomarkers.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CN-W (92)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: DURHAM

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Project Narrative A loss of smell is associated strongly with pre-clinical Alzheimer’s Disease, yet the relationship between olfactory loss and disease progression are not understood. We have developed an approach to obtain human olfactory biopsies for single cell profiling, providing a means to directly compare neuroepithelial samples at any disease stage, focusing on sensory, supporting and immune cells. In our proposed studies, we will use this approach leveraging an Alzheimer’s Disease Research Center cohort to identify mechanistic insights into human olfactory loss as well as Alzheimer’s Disease progression.

PI_NAMEs: GOLDSTEIN, BRADLEY J (contact)

PROGRAM_OFFICER_NAME: ST  HILLAIRE-CLARKE, CORYSE

PROJECT_TERMS: Address;Aging;aging related;Air;Alzheimer's Disease;Animal Model;Anosmia;apolipoprotein E-4;Area;Attention;Automobile Driving;Autopsy;Biological Assay;Biological Markers;biomarker identification;Biopsy;Biopsy Specimen;Brain;Brain imaging;Cell Communication;Cell Separation;Cells;Cellular Assay;Chronic;Clinic;Clinical;cohort;cytokine;Data;Data Analyses;Data Set;Development;Disease;Disease Progression;experimental study;Exposure to;Functional disorder;Gene Expression;Gene Expression Profile;Genetic Transcription;Homeostasis;Human;human data;human subject;hyposmia;Immune;Impaired cognition;In Vitro;in vitro Assay;Inflammation;insight;interest;large datasets;Measures;Memory Disorders;Metadata;Microglia;minimally invasive;Molecular;Motor;Myeloid Cells;Nasal cavity;Nerve Degeneration;nerve stem cell;Nervous System;neural;Neuroepithelial;neuroepithelium;Neuroimmune;neuroinflammation;Neurons;new therapeutic target;North Carolina;olfactory bulb;olfactory disorder;Olfactory dysfunction;Olfactory Epithelium;Olfactory Mucosa;Olfactory Pathways;olfactory sensory neurons;Organ;Otolaryngology;Outpatients;Pathogenesis;Pathologic;patient oriented;Patients;Pattern;Peripheral;PLCG2 gene;Population;pre-clinical;Process;programs;Property;Protocols documentation;Psychophysics;Race;Research;Resources;response;Role;Sampling;Sensory;Sensory impairment;sensory system;Series;sex;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Smell Perception;stem cells;Structure;Subgroup;Symptoms;System;T-Lymphocyte;Techniques;Testing;therapeutic biomarker;therapeutic target;Tissues;Universities

PROJECT_TITLE: Biopsy-based single cell assays for olfactory sensory changes in an Alzheimer's Disease cohort

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 AN-Q (55)]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Kidney Disease;Patient Safety

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: While the newer classes of diabetes medications have shown clinical benefits in patients with diabetic kidney disease (DKD) in randomized controlled trials, one of the major prescribing barriers is the lack of safety data in real-world patients with DKD, a complex, older population with multimorbidity and polypharmacy, who are at greater risk for adverse events and drug-drug interactions. This proposal’s goal is to develop a framework to optimize the safety of newer diabetes medications in real-world patients with DKD. This proposal will advance our understanding of these drugs’ safety and thus, will help overcome barriers to prescribing in patients with DKD who may largely benefit from them, greatly advancing the clinical care of patients with DKD.

PI_NAMEs: PAIK, JULIE  (contact)

PROGRAM_OFFICER_NAME: PARSA, AFSHIN

PROJECT_TERMS: active comparator;Acute Renal Failure with Renal Papillary Necrosis;Address;Adverse event;adverse event risk;Affect;Age;Agonist;Amputation;Anticoagulants;Benzodiazepines;Calibration;Cardiovascular system;Clinical;clinical care;Clinical Management;clinical practice;clinically relevant;cohort;Complex;Data;data mining;Databases;Diabetes Mellitus;Diabetic Ketoacidosis;Diabetic Nephropathy;Dipeptidyl Peptidases;Disease Progression;Drug Interactions;Drug Prescriptions;Education;Effectiveness;Electronic Health Record;Ethnic Origin;Event;Exclusion;falls;Fracture;frailty;genital infection;GLP-I receptor;Glucose;Goals;Healthcare;high reward;high risk;high risk population;hyperkalemia;Hypoglycemia;Impairment;implementation efforts;Incentives;Individual;inhibitor;insight;Insulin;Kidney;Kidney Diseases;Knowledge;Link;Medicaid;Medicare;medication safety;Methodology;Monitor;multiple chronic conditions;novel;novel therapeutics;Older Population;Patient Care;Patients;Pharmaceutical Preparations;Polypharmacy;Population;programs;prospective;Race;Randomized, Controlled Trials;Renal function;Residual state;Risk;Safety;safety outcomes;Sample Size;Scanning;screening;sex;Signal Transduction;Sodium;statistics;Subgroup;Sulfonylurea Compounds;Surveillance Methods;symporter;Therapeutic;Time;Trees;Update;Urinary tract infection

PROJECT_TITLE: Optimizing the Safety of the Newer Diabetes Medications in Patients with Diabetes and Kidney Disease


NIH_SPENDING_CATS: Atherosclerosis;Biotechnology;Cardiovascular;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Heart Disease - Coronary Heart Disease;Kidney Disease;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: Project Narrative Heart disease poses a major health threat in the US, and there is a disproportionate burden of heart disease among African Americans. However, the environmental and/or genetic reasons remain incompletely defined. Our goal is to use novel technologies to study blood proteins to identify those most at risk so that preventive interventions can be made as early as possible – and to improve our understanding of the underlying disease mechanisms.

PI_NAMEs: GERSZTEN, ROBERT E (contact);WILSON, JAMES GRAHAM

PROGRAM_OFFICER_NAME: COADY, SEAN

PROJECT_TERMS: African;African American population;African ancestry;Amyloidosis;Aorta;APOL1 gene;aptamer;Arterial Fatty Streak;Base Sequence;Biological Assay;Biological Markers;Biological Models;Biology;Blood Proteins;Body mass index;Bone Marrow;Cardiometabolic Disease;cardiometabolism;causal variant;Chronic Kidney Failure;Circulation;Clinical;Collaborations;Communities;coronary artery calcium;Coronary heart disease;Data;Databases;Development;Diabetes Mellitus;Disease;Ethnic Population;Etiology;European ancestry;experimental study;follow-up;Funding;gain of function;Genetic;genetic architecture;Genetic Determinism;genetic variant;genome wide association study;Goals;Health;Heart Diseases;Heart failure;High Density Lipoprotein Cholesterol;High Fat Diet;Homologous Gene;Human;human disease;improved;in silico;Individual;Inflammation;Inflammatory;insight;Institution;Integral Membrane Protein;Intervention;Investigation;Jackson Heart Study;Kidney;Laboratories;Left Ventricular Hypertrophy;Leukocytes;Link;Lipoprotein (a);loss of function;Maps;Measures;Mediating;Mendelian randomization;Meta-Analysis;metabolomics;Methods;monocyte;mouse model;multi-ethnic;multiple omics;Mus;new technology;Non-Insulin-Dependent Diabetes Mellitus;novel;novel marker;Outcome;Pathogenesis;Pathway interactions;Pattern;Plasma;Plasma Proteins;Population;preventive intervention;progenitor;Proteins;Proteome;Proteomics;Publishing;RBP4 gene;Recombinants;Risk;Risk Factors;Risk Marker;risk variant;Sentinel;Sequence Analysis;Sickle Cell Trait;Smoking;Spleen;Stroke;Testing;Time;Tissues;trait;Triglycerides;unpublished works;Variant;whole genome;Work

PROJECT_TITLE: Proteomics of Cardiometabolic and Renal Traits in African Americans

STUDY_SECTION: CRD

STUDY_SECTION_NAME: Cardiovascular and Respiratory Diseases Study Section[CRD]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Data Science;Dementia;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences

ORG_CITY: BALTIMORE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: Narrative ASL MRI is a noninvasive technique for quantifying regional cerebral blood flow (CBF), which is altered in Alzheimer’s Disease and other neurodegenerative disorders. This project will develop advanced techniques to reduce noise, improve spatial resolution, and reduce scan time for ASL MRI and to apply the method in ASL- CBF based AD studies.

PI_NAMEs: WANG, ZE  (contact)

PROGRAM_OFFICER_NAME: HSIAO, JOHN

PROJECT_TERMS: 3-Dimensional;Address;Adopted;Adult;Affect;Algorithm Design;Algorithms;Alzheimer disease detection;Alzheimer's Disease;analytical method;arterial spin labeling;Artificial Intelligence;Basic Science;Brain;Brain region;cerebrovascular;Cerebrovascular Circulation;Clinical;Clinical Research;Code;Communities;Compensation;Conflict (Psychology);cost;Data;data acquisition;Data Set;deep learning;denoising;Differential Diagnosis;Disease;Disease Progression;Early Diagnosis;Early Intervention;Ensure;Episodic memory;experience;Head;high risk;hypoperfusion;Image;improved;indexing;innovation;Knowledge;Label;Learning;learning network;learning strategy;life span;Machine Learning;machine learning algorithm;machine learning method;machine learning model;Magnetic Resonance Imaging;Maps;Measures;Medical Imaging;Memory;Methods;Modeling;Monitor;Motion;multimodality;Neurobehavioral Manifestations;Neurodegenerative Disorders;Neurologic;neuromechanism;neuropsychiatry;Neurosciences;neurovascular;Noise;novel;Output;Patients;Pattern;Performance;Perfusion;Persons;Physiological;pre-clinical;Process;Property;Protocols documentation;Research;Research Priority;Residual state;Resolution;Risk;Scanning;Scheme;Signal Transduction;Spin Labels;stability testing;success;technique development;Techniques;Testing;Therapeutic Intervention;Time;Training;Translational Research;ultra high resolution;Variant;Work

PROJECT_TITLE: Deep-Learning Enhanced ASL MRI For Early AD Assessment


NIH_SPENDING_CATS: Diabetes;Nutrition;Obesity

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: FGF21 is a particular hormone that is made by fat cells that may be important for the development of obesity, which is currently a major public health burden. The objectives of this proposal are to examine how FGF21 released from fat cells modulates the harmful metabolic effects of obesity, and whether FGF21 released from fat is different from FGF21 derived from other parts of the body such as the liver, where it is known to exert beneficial effects on health. Strategies to specifically target FGF21 released from fat cells could lead to new therapies to combat obesity.

PI_NAMEs: DEN HARTIGH, LAURA JANE (contact)

PROGRAM_OFFICER_NAME: GUPTA, DHANANJAY

PROJECT_TERMS: Adipocytes;Adipose tissue;Affinity;Animal Model;autocrine;Autocrine Communication;blood glucose regulation;Body fat;Body mass index;Body part;Body Weight;Body Weight decreased;Brown Fat;combat;comorbidity;Complex;Data;Development;Diet;diet-induced obesity;Distal;Endocrine;Endopeptidases;energy balance;Energy Metabolism;Epidemic;Exhibits;experimental study;Fasting;Fatty acid glycerol esters;feeding;fibroblast growth factor 21;fibroblast-activating factor;gain of function;genetic manipulation;glucose metabolism;Health;Hepatic;Homeostasis;Hormones;Human;Hypertrophy;improved;Individual;insulin sensitivity;ketogenic diet;Knockout Mice;Knowledge;lipid metabolism;Liver;loss of function;Maintenance;Mediating;Messenger RNA;Metabolic;Metabolic dysfunction;Metabolism;Modeling;mouse model;Mus;novel strategies;novel therapeutic intervention;novel therapeutics;Nutritional;Obesity;obesity development;obesogenic;overexpression;paracrine;pharmacologic;Phenotype;Physiologic Thermoregulation;Physiological;Physiology;Play;Process;Proteins;Proteolysis;Public Health;receptor;Regulation;Resistance;response;Rodent;Role;Signal Transduction;Stimulus;Stress;targeted treatment;Techniques;Temperature;Tissue Expansion;Tissues;tool;Transplantation

PROJECT_TITLE: Distinct functions of adipocyte-derived FGF21 in obesity

STUDY_SECTION: POMD

STUDY_SECTION_NAME: Pathophysiology of Obesity and Metabolic Disease Study Section[POMD]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Genetics;Human Genome;Neurosciences;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: LOS ANGELES

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

ORG_STATE: CA

PHR: PROJECT NARRATIVE CRISPR has revolutionized our approaches to study cancer, allowing rapid functional interrogation at transcriptome-wide scales. However, single-cell sequencing compatible transcriptome-wide screens in autochthonous genetically engineered models remain a challenge. Here we propose a novel methodology to enable transcriptome-scale multiplex gain and loss of function CRISPR screens that is compatible with our robust MADR tumor modeling approach in human 3D organoid models and well-characterized “off-the-shelf” mouse lines.

PI_NAMEs: BREUNIG, JOSHUA JOHN (contact)

PROGRAM_OFFICER_NAME: DUECK, HANNAH RUTH

PROJECT_TERMS: 3-Dimensional;Advanced Development;anti-cancer research;Applications Grants;Bar Codes;Biological;Biology;Brain Neoplasms;Cancer Etiology;cancer type;Cause of Death;Cells;Chemicals;Chemotherapy and/or radiation;Child;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;cost effective;CRISPR screen;CRISPR-mediated transcriptional activation;CRISPR/Cas technology;diffuse midline glioma;DNA Insertion Elements;driver mutation;Electroporation;Elements;Engineering;Ependymoma;Evolution;Excision;experience;experimental study;fitness;gain of function;Gene Transfer Techniques;Generations;Genes;Genetic;genetic element;Genetic Engineering;Genetic Screening;genome editing;genome wide screen;genomic locus;Genomics;Glioblastoma;Glioma;Goals;Growth;Hour;Human;Human Engineering;human induced pluripotent stem cells;human model;Immunocompetent;In Vitro;in vivo;induced pluripotent stem cell;insight;large scale data;Learning;Libraries;life history;Link;loss of function;Malignant Neoplasms;Mediating;Methodology;Methods;Modeling;Modernization;Molecular;mosaic analysis;multiple omics;Mus;Mutation;novel;novel therapeutics;Open Reading Frames;Organoids;Patients;Plasmids;Proteins;Radiation therapy;rapid technique;recombinase;recombinase-mediated cassette exchange;Recurrence;RELA gene;Reporter;Resistance;Resolution;screening;Signal Transduction;single cell sequencing;single-cell RNA sequencing;Somatic Mutation;standard of care;Supratentorial;Survival Rate;System;Techniques;Technology;temozolomide;Testing;Therapeutic;tool;transcriptome;transcriptomics;Transgenic Organisms;tumor;tumor heterogeneity;tumorigenesis;Validation;Variant;Viral;Work;young adult

PROJECT_TITLE: Enabling in vivo barcoded single-cell multiomics-compatible genome-wide screens in personalized tumor models using defined-copy somatic transgenesis

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 TCRB-Q (O1)]


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Clinical Research;Digestive Diseases;Liver Disease;Microbiome

ORG_DEPT: PHARMACOLOGY

ORG_STATE: WA

PHR: The proposed research aims to elucidate the interactions between gut microbiome and liver metabolism in responding to exposure to benzalkonium chloride (BAC) disinfectants in animal models and assess the impact of BAC exposure on gut microbiome diversity and function in humans. This project relates to NIH’s goals in understanding the biological effects of environmental contaminants and the prevention and cure of human diseases.

PI_NAMEs: XU, LIBIN  (contact)

PROGRAM_OFFICER_NAME: DZIERLENGA, ANIKA LIN

PROJECT_TERMS: Affect;Animal Model;antimicrobial;Bacteria;Benzalkonium Chloride;bile acid metabolism;Bile Acids;Biliary;Biological;Blood;Blood specimen;Chronic;constitutive androstane receptor;consumer product;COVID-19;COVID-19 pandemic;CYP2D6 gene;Cytochrome P450;Data;Detection;Disinfectants;Dose;Environmental Pollutants;Enzymes;Excretory function;exposure route;Exposure to;fecal microbiome;Feces;Food processing industry;Foundations;Frequencies;Future;gene environment interaction;Gene Expression;Genes;Germ-Free;Goals;gut microbiome;gut-liver axis;Health;Human;human disease;Individual;innovation;Intestines;Knowledge;Ligands;lipid metabolism;lipidomics;Lipids;Liver;Liver diseases;liver function;liver metabolism;Liver Microsomes;Local Anti-Infective Agents;Measures;Medical;Metabolic;Metabolic Diseases;Metabolic Pathway;Metabolism;metabolome;metagenomic sequencing;meter;microbial;microbiome;microbiome composition;microbiota;Mus;novel;Nuclear Receptors;Oral;Outcome;pandemic disease;Plasma;Population;PPAR alpha;pre-pandemic;pregnane X receptor;Prevention;Protein Isoforms;receptor;Receptor Signaling;Reporting;Research;response;Risk;Role;Route;Safety;Sampling;Shotguns;Signal Transduction;Sterols;stool sample;transcriptome sequencing;United States National Institutes of Health;Xenobiotic Metabolism;Xenobiotics

PROJECT_TITLE: Impact of benzalkonium chloride on gut microbiome and gut-liver interactions

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 KUDS-Y (04)]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Hematology;Human Genome;Immunotherapy;Lymphatic Research;Lymphoma;Precision Medicine;Rare Diseases

PHR: PROJECT NARRATIVE Aggressive B cell lymphomas are a very common type of cancer with varied outcomes for patients—some are cured with standard treatment, but others are not. The goal of this research is to identify biomarkers that can identify which patients are likely to be cured, and which patients might need new treatments. The biomarkers may also tell us if certain types of immune targeting therapies would be useful for certain types of patients.

PI_NAMEs: MERCHANT, AKIL  (contact)

PROGRAM_OFFICER_NAME: BHARTI, SANITA

PROJECT_TERMS: Address;Adoptive Transfer;Adult;B-Cell Lymphomas;B-Lymphocytes;Biological Markers;Biological Models;biomarker identification;cancer cell;cancer type;candidate marker;candidate validation;Cells;Chemoresistance;Classification;Clinical;cohort;Complex;Congenic Mice;Cytometry;Data;Development;Elements;Ensure;exome sequencing;Gene Expression;Generations;Genetic;Genetic Models;Genetic Variation;Goals;Grant;Hematologic Neoplasms;Histologic;Human;human disease;Image;Immune;Immune checkpoint inhibitor;Immune Targeting;Immunohistochemistry;Immunophenotyping;Immunotherapy;In Vitro;in vitro Model;in vivo Model;insight;Institution;International Prognostic Index;large cell Diffuse non-Hodgkin's lymphoma;Link;Lymphoma;Malignant Neoplasms;Mediating;Methods;Modeling;Molecular;Molecular Profiling;Monitor;mosaic analysis;mouse model;Mus;Mutation;Nature;neoplastic cell;next generation;Non-Hodgkin's Lymphoma;Non-Malignant;novel;novel strategies;nucleofection;Oncogenic;Outcome;parent grant;parent project;Parents;Pathologist;Patient-Focused Outcomes;Patients;Phenotype;pre-clinical;Pre-Clinical Model;Preclinical Testing;predictive marker;Prognostic Marker;programmed cell death ligand 1;protein biomarkers;Publishing;recombinase-mediated cassette exchange;Recurrence;Research;Resolution;response;Role;Sample Size;Sampling;standard care;Structure;Subgroup;survival prediction;Systems Biology;targeted agent;targeted cancer therapy;targeted treatment;Technology;Testing;Tissues;transcriptomics;tumor;tumor growth;Tumor Markers;tumor-immune system interactions;Validation

PROJECT_TITLE: Generation of novel murine B-cell lymphoma models using mosaic analysis by dual recombinase-mediated cassette exchange (MADR) to more closely resemble human B-cell lymphomas

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 TCRB-5 (O2)]


NIH_SPENDING_CATS: Cancer;Childhood Leukemia;Hematology;Immunotherapy;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: DUARTE

ORG_NAME: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE

PHR: Project Narrative Overall outcome for patients with acute myeloid leukemia (AML) remains unfavorable. The limited applicability of allogeneic hematopoietic stem cell transplantation (allo-HSCT) as well as the rise of the immunotherapy era highlights a pressing need to develop novel immune-stimulating drugs for AML eradication. To address this challenge, herein, we will determine whether targeting PRMT9 promotes a sustained leukemia-eliminating immunity and assess whether a PRMT9 inhibitor combined with an immune checkpoint inhibitor eliminates AML cells in-vivo.

PI_NAMEs: LI, LING  (contact)

PROGRAM_OFFICER_NAME: KLAUZINSKA, MALGORZATA

PROJECT_TERMS: Ablation;Acute Lymphocytic Leukemia;Acute Myelocytic Leukemia;acute myeloid leukemia cell;Address;Aftercare;Allogenic;Animal Model;anti-PD-1;Antigen Targeting;Antigen-Presenting Cells;Bone Marrow;Bone Marrow Cells;cancer cell;Cell Compartmentation;Cell Proliferation;cell type;Cells;cellular engineering;checkpoint therapy;chimeric antigen receptor T cells;Chromosome abnormality;Clinical;Cytogenetics;Development;DNA Damage;Drug Targeting;effective therapy;Engraftment;extracellular;FLT3 gene;Funding;Hematologic Neoplasms;Hematopoietic;Hematopoietic Stem Cell Transplantation;high risk;Human;humanized mouse;Immune;immune activation;immune checkpoint;Immune checkpoint inhibitor;Immune Evasion;Immunity;Immunologic Stimulation;Immunologic Surveillance;Immunotherapy;immunotoxicity;Implant;in vivo;inhibitor;Interferon Type I;Knock-out;Laboratories;lead optimization;leukemia;leukemia treatment;Leukemic Cell;Lymphoma;Machine Learning;Malignant Neoplasms;MLL-AF9;Modeling;Molecular;molecular dynamics;Mononuclear;mouse model;Mus;Non-Hodgkin's Lymphoma;novel;Oncogenic;Outcome;overexpression;Pathway interactions;Patient-Focused Outcomes;Patients;PD-1 inhibitors;Pharmaceutical Preparations;pharmacologic;Production;programmed cell death protein 1;protein function;Protein-Arginine N-Methyltransferase;Proteins;relapse risk;Reporting;Repression;response;risk stratification;Signal Transduction;single-cell RNA sequencing;Specimen;Stimulator of Interferon Genes;STING agonists;T-Lymphocyte;targeted treatment;Testing;Therapeutic;Therapeutic Uses;transcriptome;transcriptomics;Translations;transplant model;Transplantation;Treatment outcome;tumor;Work

PROJECT_TITLE: Targeting Protein Arginine Methyltransferases to Eradicate Acute Myeloid Leukemia

STUDY_SECTION: MCTB

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics B Study Section[MCTB]


NIH_SPENDING_CATS: Biomedical Imaging;Brain Disorders;Genetics;Human Genome;Mental Health;Mental Illness;Neurosciences

PHR: Project Narrative Many human illnesses, such as neuropsychiatric disorders are heritable, but the connection among genes, brain structure and neuropsychiatric disorders is not well understood. Through application of genetically-based cortical atlases and new statistical approaches in a large sample with brain imaging and genotyping data, we will identify genetic variants associated with structural variation of the human brain. These findings in turn may help us better understand the pathogenesis of neuropsychiatric disorders.

PI_NAMEs: CHEN, CHI-HUA  (contact)

PROGRAM_OFFICER_NAME: PRICE, AMANDA JOY

PROJECT_TERMS: Adolescent;Anatomy;Atlases;biobank;Biological;Brain;Brain imaging;brain magnetic resonance imaging;brain morphology;Brain region;brain shape;causal variant;Cerebral cortex;Chromosome Mapping;clinical phenotype;cognitive development;cohort;cost;Data;Data Collection;Development;Diagnostic;Disease;Dosage Compensation (Genetics);endophenotype;Enhancers;exome;experimental study;Face;Female;Future;Gene Targeting;Genes;Genetic;Genetic Heterogeneity;Genetic Models;Genetic Risk;genetic testing;genetic variant;genome wide association study;genomic locus;Genomic Segment;Genotype;Goals;Hereditary Disease;Human;Image;improved;Incidence;Individual;insight;Knowledge;Link;Literature;Magnetic Resonance Imaging;male;Measures;Mediating;Mendelian randomization;Mental disorders;Methodology;Methods;Modeling;Molecular;Morphology;Nature;neurodevelopment;neuroimaging;neuropsychiatric disorder;neuropsychiatry;Neurotic Disorders;Pathogenesis;Pathway interactions;Pattern;Phenotype;pleiotropism;polygenic risk score;Population Genetics;Prevalence;Process;Quantitative Trait Loci;research study;Risk;Sample Size;Sampling;Science;sex;Sex Chromosomes;Sex Differences;Single Nucleotide Polymorphism;Single Nucleotide Polymorphism Map;Structure;Subgroup;Testing;therapeutic development;therapeutic target;trait;Twin Multiple Birth;Untranslated RNA;Variant;Work;X Chromosome

PROJECT_TITLE: Genetic heterogeneity and pleiotropy of neuroimaging and psychiatric phenotypes

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Precision Medicine;Prevention;Serious Mental Illness

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: Project Narrative The typical selection method of therapies for patients with major depressive disorder has not changed for many decades, involving a trial-and-error approach without firm biological rationale. This project examines a candidate EEG biomarker to improve understanding of brain function with the long-term goal of optimally selecting depressed patients for novel interventions such as ketamine/esketamine.

PI_NAMEs: MATHEW, SANJAY J (contact);MURPHY, NICHOLAS

PROGRAM_OFFICER_NAME: SABBAGH, JONATHAN JACOB

PROJECT_TERMS: Address;Adult;Age;Alcohol consumption;antagonist;anti-depressive agents;Biological;Biological Markers;Biological Models;Bipolar Disorder;Brain;candidate marker;Chemosensitization;Clinic;Clinical;Clinical Markers;clinical practice;community partners;Control Groups;cost;Crossover Design;depressed patient;depressive symptoms;Development;Diagnosis;disability;Disease;Drug Kinetics;Electroencephalography;Elements;Equilibrium;Exclusion;Exploratory/Developmental Grant;Glutamates;Goals;Heterogeneity;improved;Individual;Infusion procedures;innovation;Intervention;Intravenous;Investigation;Ketamine;Link;Major Depressive Disorder;Measurement;Measures;Mechanics;Mental Depression;Methods;middle age;Modeling;multilevel analysis;N-Methyl-D-Aspartate Receptors;neural circuit;neurophysiology;neuroregulation;Nose;novel;Outcome;Patient Selection;Patients;Pattern;personalized care;Pharmaceutical Preparations;Phase;Post-Traumatic Stress Disorders;preclinical study;Prediction of Response to Therapy;Procedures;Process;Prognosis;prognostic;prognostic indicator;Prognostic Marker;Proliferating;prospective;Psychiatrist;Psychotherapy;psychotic;Public Health;Research;Resistance;response;Rest;Saline;Sampling;Schedule;sex;Shapes;success;symptomatic improvement;Synapses;System;Therapeutic;tool;translational potential;Treatment outcome;treatment stratification;treatment-resistant depression;Variant

PROJECT_TITLE: Gamma oscillations as a prognostic marker for ketamine therapy in treatment resistant depression

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


NIH_SPENDING_CATS: Biomedical Imaging;Childhood Obesity;Chronic Liver Disease and Cirrhosis;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Digestive Diseases;Liver Disease;Nutrition;Obesity;Pediatric

ORG_CITY: CHICAGO

ORG_NAME: LURIE CHILDREN'S HOSPITAL OF CHICAGO

ORG_STATE: IL

PHR: Public Health Relevance This study will examine the effect of a novel treatment for treating non-alcoholic fatty liver disease among adolescents with obesity. Furthermore, we will examine the mechanism by which this treatment changes insulin sensitivity, glycemic control, and liver fat content. If successful, this trial represents a first step toward a clinically relevant treatment of pediatric non-alcoholic fatty liver disease and a greater understanding of how empagliflozin works.

PI_NAMEs: CRAWFORD, PETER A;RYDER, JUSTIN R. (contact)

PROGRAM_OFFICER_NAME: LOH, KATRINA SHUEH WEN

PROJECT_TERMS: 19 year old;Acetyl Coenzyme A;Address;Adipose tissue;Adolescent;Adult;Aftercare;Age;Animal Model;Automobile Driving;Blood;Body Composition;Body fat;Body mass index;Body measure procedure;Body Weight;Childhood;Cirrhosis;Clinical;clinical care;Clinical Trials;clinically relevant;Data;density;Deposition;Diabetes Mellitus;Disease;Dose;Dual-Energy X-Ray Absorptiometry;effective therapy;Enzymes;Extrahepatic;Fasting;Fatty acid glycerol esters;Fatty Acids;Glucagon;Gluconeogenesis;Glucose;Glucose Clamp;glucose production;glucose tolerance;glycemic control;Glycosuria;Hepatic;Hyperinsulinism;improved;inhibitor;inhibitor therapy;innovation;Insulin;Insulin Resistance;insulin sensitivity;Investigation;ketogenesis;life span;Lipolysis;Liver;Liver diseases;liver injury;Liver Mitochondria;liver transplantation;Magnetic Resonance Imaging;Magnetic Resonance Spectroscopy;Measures;Mechanics;Medical;Metformin;Methods;non-alcoholic fatty liver disease;non-diabetic;Non-Insulin-Dependent Diabetes Mellitus;nonalcoholic steatohepatitis;novel;Obesity;Oral;oxidation;pediatric non-alcoholic fatty liver disease;Pediatrics;Peripheral;Pharmaceutical Preparations;Pharmacotherapy;Placebos;Population;Positioning Attribute;Prevalence;Primary carcinoma of the liver cells;Protons;public health relevance;randomized placebo controlled trial;Randomized, Controlled Trials;Research;response;Sodium;Source;stable isotope;symporter;Testing;Thiazolidinediones;Time;Tracer;Venous;Visceral fat;Work

PROJECT_TITLE: Mechanisms of SGLT2 Inhibition in Pediatric NAFLD

STUDY_SECTION: HSDO

STUDY_SECTION_NAME: Human Studies of Diabetes and Obesity Study Section[HSDO]