ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Behavioral and Social Science;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Patient Safety;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE The majority of health care appointments in the United States end with at least one prescription being written for the patient, but doctors may not have the necessary tools to choose the best medication and dose for any given disease or condition. The overarching goal of this proposal is to develop improved strategies that better inform clinicians on how to prescribe therapy that maximizes efficacy and minimizes harm based on the unique characteristics (demographics, genes, environment, and lifestyle) of a given patient. To do this, we will study past electronic health records from hundreds of thousands of patients to observe how they responded to drug therapy and look for patterns that link unique characteristics to favorable outcomes after taking a given medication.

PI_NAMEs: ONI-ORISAN, AKINYEMI  (contact)

PROGRAM_OFFICER_NAME: VOLPI, SIMONA

PROJECT_TERMS: Address;admixture mapping;Adverse drug event;African American population;All of Us Research Program;American;Appointment;biobank;Biological;Biology;Biomedical Research;Black race;cardiovascular disorder epidemiology;care outcomes;Characteristics;Clinical;Clinical Pharmacology;clinical practice;cohort;Communities;Country;Data;Data Set;demographics;Descriptor;Disease;Disease susceptibility;diverse data;Dose;drug efficacy;East Asian;efficacy outcomes;Electronic Health Record;Ensure;Environment;Epigenetic Process;Equity;ethnic difference;ethnic minority;Ethnic Origin;Ethnic Population;European;Exclusion;Failure;Foundations;Future;Gene Expression;Genes;Genetic;Genetic Determinism;Genetic Polymorphism;genetic variant;genome sequencing;genome wide association study;genome-wide;genome-wide analysis;Goals;Harm Reduction;Health;health care disparity;Healthcare;Heritability;improved;Individual;Infrastructure;insight;Institution;Knowledge;Label;Latino;Latino Population;Life Style;Link;medication compliance;medication safety;Mexican Americans;Minority Groups;Molecular Genetics;multidisciplinary;non-genetic;novel;Outcome;parent grant;Participant;Patients;Pattern;Pharmaceutical Preparations;Pharmacogenetics;Pharmacogenomics;pharmacologic;Pharmacotherapy;Phenotype;Population;Population Heterogeneity;predicting response;predictive modeling;prevent;Proxy;Puerto Rican;Quantitative Trait Loci;Race;racial difference;racial minority;racial population;Recommendation;Reporting;Research;Resources;response;safety outcomes;side effect;social determinants;social factors;social health determinants;sociodemographics;Source;South Asian;study population;Therapeutic;tool;Traction;transcriptome;Underrepresented Populations;United States;United States Food and Drug Administration;United States National Institutes of Health;Variant;whole genome;Work;Writing

PROJECT_TITLE: Genetic and social determinants of pharmacological health outcomes in ancestrally diverse populations (Warren)


ADMINISTERING_IC: NS

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Neurodegenerative;Neurosciences;Peripheral Neuropathy

ORG_CITY: STANFORD

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOPHYSICS

ORG_FIPS: US

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: Project Narrative Peripheral and autonomic neuropathies degrade quality of life and are prevalent in patients receiving chemotherapy and living with diabetes, but few treatments exist to alleviate these conditions. Because our skin and internal organs are in constant motion, so are the sensory neurons embedded in these tissues. The proposed multidisciplinary experiments and integrated theoretical research exploits a simple genetic model to develop a comprehensive understanding of how mechanical force is detected by sensory neurons and how these self-same neurons bend without breaking, focusing on cytoskeletal structures like microtubules and spectrin that are conserved in humans and implicated in sensitivity to traumatic brain injury.

PI_NAMEs: GOODMAN, MIRIAM B (contact)

PROGRAM_OFFICER_NAME: MOHAPATRA, DURGA PRASANNA

PROJECT_TERMS: Activities of Daily Living;Address;Affect;Afferent Neurons;Animals;autonomic neuropathy;Biophysics;Caenorhabditis elegans;Calcium;cantilever;Chemicals;chemotherapy;Cytoskeleton;Devices;Diabetes Mellitus;Dissection;Electrophysiology (science);Encapsulated;Engineering;experimental study;Genetic;Genetic Models;Glucose;Health;Human;Image;Invertebrates;Joints;Knowledge;Link;mechanical force;mechanical signal;mechanical stimulus;Mechanics;Microfluidics;Microtubules;Molecular;Monitor;Morphology;Motion;Movement;multidisciplinary;Muscle;Nematoda;Neurons;Optics;Organ;Paclitaxel;Patients;Perception;Performance;Peripheral Nervous System Diseases;programs;Quality of life;Research;Signal Transduction;simulation;Skin;somatosensory;Spectrin;Stress;stressor;Structure;Surface;Tactile;theories;Tissues;tool;Touch sensation;Translating;Traumatic Brain Injury;Visceral;Work

PROJECT_TITLE: The biophysics of skin-neuron sensory tactile organs and their sensitivity to mechanical and chemical stress


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

ORG_DEPT: PHARMACOLOGY

PROJECT_TITLE: Genetic and social determinants of pharmacological health outcomes in ancestrally diverse populations (Recto)


NIH_SPENDING_CATS: Clinical Research;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Patient Safety;Precision Medicine;Prevention

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PROJECT NARRATIVE The Genomic Risk Assessment Coordinating center for eMERGE (GRACE) will create infrastructure to implement and evaluate genomic risk assessments for common, complex diseases such as heart disease, and return these assessments to participants. GRACE will organize collaboration among eMERGE investigators, streamline data collection, and utilize cloud computing to enable large scale analyses of genomic data. GRACE will support the recruitment and genotyping of a 20,000 person cohort to determine the clinical impact of delivering genomic risk assessments, measure the uptake of risk reduction recommendations, and assess changes to clinical outcomes.

PI_NAMEs: LENNON, NIALL JOHN;PETERSON, JOSEPH F. (contact)

PROGRAM_OFFICER_NAME: ROWLEY, ROBB KENNETH

PROJECT_TERMS: Adult;All of Us Research Program;biobank;Case Report Form;Childhood;Clinical;clinical risk;clinical translation;clinically actionable;Cloud Computing;cohort;Collaborations;Communication;Communities;Complex;Computerized Medical Record;Contracts;Data;Data Analyses;Data Collection;data management;Data Science;data tools;Databases;Dedications;design;Development;Diagnosis;Disease;disease phenotype;disorder prevention;Effectiveness;Electronic Health Record;Electronic Medical Records and Genomics Network;Electronics;Evolution;experience;Family;Family health status;Feedback;Funding;Genome;genomic data;Genomic medicine;Genomics;Genotype;Heart Diseases;Home;improved;Individual;Informatics;Infrastructure;innovation;Institutional Review Boards;International;Intervention;Knowledge;Laboratories;Leadership;Manuscripts;Measures;member;Methods;Monitor;multi-ethnic;multidisciplinary;National Human Genome Research Institute;Nature;Outcome;Outcome Assessment;Participant;patient oriented;Patients;Persons;Phase;Phenotype;point of care;polygenic risk score;Population Heterogeneity;precision medicine;Principal Investigator;Process;Productivity;programs;Prospective Studies;Provider;Publishing;real world application;Recommendation;Recording of previous events;recruit;Reporting;repository;Research;Research Methodology;Research Personnel;Resources;Risk;Risk Assessment;Risk Factors;Risk Management;Risk Reduction;Role;Services;success;support network;tool;Translating;Universities;uptake;Validation;Vision;Visualization;Work

PROJECT_TITLE: Invitae Supplement 2: eMERGE Risk Assessment Network Coordinating Center


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Clinical Research;Urologic Diseases

ORG_CITY: DURHAM

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE Lower urinary tract symptoms (LUTS) are common and costly, and most available therapeutic options do not provide long-term symptom relief. The proposed research will increase understanding of LUTS subtypes, the underlying mechanisms behind different subtypes, and will develop and refine comprehensive, validated, and responsive measurement tools for defining treatment efficacy. This work is relevant to public health as it has the potential to improve diagnosis and treatment of LUTS.

PI_NAMEs: AMUNDSEN, CINDY  (contact);JELOVSEK, JOHN ERIC

PROGRAM_OFFICER_NAME: MULLINS, CHRISTOPHER V

PROJECT_TERMS: Adult;Age;Bladder;Categories;Characteristics;Classification;Clinical;clinical examination;cohort;common symptom;Communities;Consensus;cost;Data;Data Scientist;Decision Making;Development;Diagnosis;Economics;Epidemiologist;experience;Failure;Functional disorder;Future;Heterogeneity;improved;Internist;Knowledge;Laboratories;Low Prevalence;Lower urinary tract;lower urinary tract symptoms;Measurement;Measures;men;Modeling;multidisciplinary;novel;Outcome;Participant;Patient Self-Report;patient subsets;Patient-Focused Outcomes;Patients;Phenotype;Plasma;Population;Population Heterogeneity;Probability;Process;Proteins;Public Health;Quality of life;reduce symptoms;Reporting;Research;Research Personnel;Severities;social;Subgroup;symptom cluster;symptom treatment;Symptoms;Testing;Therapeutic;tool;Treatment Efficacy;Treatment outcome;Urodynamics;Urologist;Woman;Work

PROJECT_TITLE: Advancing the Measurement and Classification of Lower Urinary Tract Dysfunction


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: MINNEAPOLIS

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE A healthy retina relies on the proper function of the blood-retina barrier, i.e., the interface between blood vessels and retina that mediates highly selective transport of nutrients, hormones, and metabolic waste. Multiple retinal diseases are associated with blood-retina barrier dysfunction. Here, we will use cell-based systems and mouse models to determine the mechanism of action and efficacy of a novel drug candidate that promotes blood-retina barrier function.

PI_NAMEs: ANGERS, STEPHANE ;JUNGE, HARALD  (contact)

PROGRAM_OFFICER_NAME: GORDIYENKO, NATALIYA

PROJECT_TERMS: Active Biological Transport;Agonist;Anti-Inflammatory Agents;Antibodies;beta catenin;bevacizumab;Blood;Blood Vessels;Blood-Retinal Barrier;Cells;Characteristics;Choroidal Neovascularization;Coats' disease;Complex;Defect;density;Diabetic Retinopathy;Disease;disease model;drug candidate;efficacy evaluation;Endothelial Cells;experimental study;Extravasation;Familial exudative vitreoretinopathy;Functional disorder;functional mimics;Hormones;Human;Immune;Investigation;lipoprotein receptor related protein 5;Low Density Lipoprotein Receptor;macula;macular edema;Mediating;Metabolic;Modality;Modeling;mouse model;novel;novel therapeutics;Nutrient;Nutritional Requirements;Pathway interactions;Patients;Pharmaceutical Preparations;Pharmacodynamics;receptor;Resistance development;restoration;Retina;Retinal Diseases;Retinopathy of Prematurity;Signal Induction;Signal Transduction;solute;System;Telangiectasis;Testing;Therapeutic;transcriptomics;Uveitis;wasting;WNT7A gene

PROJECT_TITLE: Investigation of a first-in-class Frizzled4/LRP5 agonist in retinal disease models


ORG_CITY: ATLANTA

ORG_DEPT: GENETICS

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Classic galactosemia (CG) is one of the most common metabolic disorders identified by newborn screening in the United States, yet despite neonatal diagnosis and lifelong dietary restriction of galactose, which is the current standard of care, most children with CG grow to experience a range of developmental and other disabilities. There is currently no approved treatment that prevents or resolves these complications. The proposed research will leverage our existing GALT-null rat model for CG to define key aspects of an AAV9-based gene therapy approach to intervention, establishing a pre-clinical foundation for future translation to patients.

PI_NAMEs: FRIDOVICH-KEIL, JUDITH L. (contact)

PROGRAM_OFFICER_NAME: EGGERMAN, THOMAS L

PROJECT_TERMS: Address;Adult;Age;Area;behavior test;behavioral outcome;Biochemical;Biochemical Markers;Birth;Blood;Blood specimen;Brain;Cataract;cell type;Cells;Chemistry;Child;Chronic;Classical galactosemia;Clinical Trials;Cognitive;Cognitive deficits;cognitive function;Cytoplasm;Detection;Development;Diagnosis;dietary restriction;disability;Dose;Early Diagnosis;enzyme replacement therapy;Enzymes;Equilibrium;Euthanasia;experience;Exposure to;Eye;Female;Foundations;Freezing;Future;Galactitol;Galactose;gene therapy;Genetic Diseases;Goals;Gonadal structure;Growth;Harvest;Histology;Human;Immunohistochemistry;improved;Inborn Errors of Metabolism;Injections;Intervention;intravenous administration;Life;Liver;Location;Medical;Messenger RNA;Metabolic;Metabolic Diseases;Modeling;morris water maze;Motor;motor deficit;Muscle;Neonatal;Neonatal Screening;Outcome;Pathology;Patient-Focused Outcomes;Patients;Phenotype;Pilot Projects;Plasma;pre-clinical;preclinical study;prevent;Process;pup;Rattus;Reporting;reproductive;Research;restoration;Safety;safety testing;Sampling;Signal Transduction;Solid;Speech;standard of care;Tail;Testing;therapy design;tissue fixing;Tissues;Translations;Uncertainty;United States;Veins;Viral Genome;Viral Vector;Virus;Work

PROJECT_TITLE: Gene Therapy in a GALT-null Rat Model of Classic Galactosemia

STUDY_SECTION: TAG

STUDY_SECTION_NAME: Therapeutic Approaches to Genetic Diseases Study Section[TAG]


ADMINISTERING_IC: AA

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Neurosciences;Prevention;Substance Misuse

ORG_CITY: COLUMBIA

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

ORG_STATE: MO

PHR: PROJECT NARRATIVE In any given year, over 10% of the adult population in the United States engages in excessive alcohol use, which has myriad negative personal and public health consequences. One reason why certain individuals develop disordered and excessive alcohol use may be that their brains’ reward system is primed to learn about cues that predict rewards and is especially sensitive to alcohol reward, such that these individuals lose the ability to control themselves when confronted with cues that their brain has learned are signals for alcohol. This project will begin develop different ways to measure this between-person difference in the laboratory and test if these laboratory measures can predict changes in problematic alcohol use over time.

PI_NAMEs: COFRESI, ROBERTO U (contact)

PROGRAM_OFFICER_NAME: GRAKALIC, IVANA

PROJECT_TERMS: addiction;Address;Adult;affective neuroscience;Alcohol abuse;alcohol abuse therapy;Alcohol consumption;alcohol cue;Alcohol dependence;alcohol involvement;alcohol related problem;alcohol research;alcohol reward;alcohol risk;alcohol sensitivity;alcohol use disorder;Alcoholic Beverages;Alcoholic Intoxication;Alcohols;Area;Association Learning;Award;Behavioral;Behavioral Mechanisms;behavioral phenotyping;blood oxygenation level dependent response;Brain;career;career development;Clinical;clinical development;Cognitive;Conditioned Reflex;conditioning;craving;cue reactivity;Cues;Dedications;Desire for food;Development;Development Plans;Diagnosis;Disease;disorder prevention;disorder risk;Educational workshop;efficacious treatment;Electroencephalography;Etiology;Event-Related Potentials;Exhibits;experience;Faculty;Functional Magnetic Resonance Imaging;Future;Goals;Heavy Drinking;Heterogeneity;Home;Human;improved;incentive salience;Incentives;Individual;Individual Differences;Institution;Knowledge;Laboratories;Learning;Link;Literature;Measurable;Measures;Mentors;Methods;Mission;Missouri;Modeling;Motivation;National Institute on Alcohol Abuse and Alcoholism;neural circuit;neurobehavioral;neurobiological mechanism;Neurobiology;neuroimaging;neurophysiology;Nucleus Accumbens;Participant;Pathway interactions;peer;Persons;Phase;Phenotype;Population;Positioning Attribute;post-doctoral training;pre-clinical;Pre-Clinical Model;preference;Prevention;programs;psychologic;Psychopathology;Public Health;Recording of previous events;Research;Research Personnel;Research Support;Rewards;Role;Sampling;Science;Scientist;Signal Transduction;skills;Smell Perception;Strategic Planning;sugar;symposium;System;Taste Perception;Testing;theories;Time;Training;Training Programs;Translating;translational neuroscience;Translations;United States;United States National Institutes of Health;Universities;Variant;Vision;Visit;Visual;Work

PROJECT_TITLE: A translational human laboratory Pavlovian conditioning model of individual differences in risk for alcohol cue incentive salience sensitization and longitudinal assessment of problematic alcohol use

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Genetics

ORG_CITY: Nashville

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: VANDERBILT UNIVERSITY

PHR: Exposures to the environmental genotoxin aflatoxin B1 (AFB1) factor in etiology of hepatocellular cancer (HCC). Genetic polymorphisms in the hNEIL1 DNA repair glycosylase, and error-prone bypass of AFB1- DNA damage by DNA polymerases may increase risk for HCC; we seek to determine how AFB1 DNA damage is repaired and replicated. Chemistry underlying AFB1 DNA damage is sequence-dependent; we seek to understand how it contributes to the AFB1 mutagenic signature.

PI_NAMEs: STONE, MICHAEL P (contact)

PROGRAM_OFFICER_NAME: SHAUGHNESSY, DANIEL

PROJECT_TERMS: Active Sites;adduct;Aflatoxin B1;aflatoxin B1-DNA adduct;Africa South of the Sahara;Area;Aspergillus flavus;base;Base Excision Repairs;Base Pairing;Binding;Biochemical;Biological Assay;Bypass;Characteristics;Chemistry;China;cohort;Complex;COSY;Cryoelectron Microscopy;Crystallization;Crystallography;Cytosine;DNA;DNA Adducts;DNA biosynthesis;DNA Damage;DNA glycosylase;DNA lesion;DNA polymerase zeta;DNA Repair;DNA replication fork;DNA Sequence;DNA-Directed DNA Polymerase;ds-DNA;early onset;Embryo;Environmental Exposure;Enzymes;Epigenetic Process;Epoxy Compounds;Etiology;exome sequencing;Exposure to;Family;Fapy-dG;Fibroblasts;General Population;Genes;Genetic;Genetic Polymorphism;genetic risk factor;genotoxicity;HMQC;Holoenzymes;Hot Spot;Human;Hydrogen Bonding;In Situ;Incubated;intercalation;Kinetics;Lactams;Lesion;Link;Malignant Neoplasms;Measures;Methylation;Modeling;Molecular Conformation;Monitor;Mus;Mutagenesis;Mutagens;Mutation;Mycotoxins;NOESY;Nucleotides;Patients;Pattern;Play;Polymerase;Primary carcinoma of the liver cells;Process;Reaction;Reagent;recruit;Repair Complex;repaired;Risk;Role;Site;Spottings;Structure;Testing;Thermodynamics;Variant;Work

PROJECT_TITLE: DNA Adduct-Induced Mutagenesis

STUDY_SECTION: MSFC

STUDY_SECTION_NAME: Macromolecular Structure and Function C Study Section[MSFC]


ADMINISTERING_IC: AI

FUNDING_MECHANISM: NON SBIR/STTR CONTRACTS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: SAN JOSE

ORG_NAME: CCS ASSOCIATES, INC.

PI_NAMEs: BRAKAJ, ROBERT  (contact)

PROJECT_TERMS: clinical application;Clinical Research;Clinical Trials;Communicable Diseases;Contracts;Good Clinical Practice;National Institute of Allergy and Infectious Disease;Operations Research;programs;quality assurance;Regulation;Research;response;Support Contracts;Vendor

PROJECT_TITLE: Vendor Audit Support Through the Comprehensive and Rapid Response to NIAID Research Programs (CARRRP) Contract


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Disorders;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hydrocephalus;Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases;Social Determinants of Health

ORG_CITY: Newburyport

ORG_NAME: ENCLEAR THERAPIES, INC.

ORG_STATE: MA

PHR: Project Narrative Relevance to Public Health: EnClear Therapies is performing research under a National Institutes of Health Phase ½ FastTrack Small Business Innovation Research (SBIR) Parent Grant: 1R44NS135792-01 to develop a more effective way of delivering therapeutics to the central nervous system. The EnClear system will improve the outcomes of patients with neurological disease by delivering needed therapeutics, in a precise personalized manner that overcomes the issue of poor CNS penetration. This administrative supplement will increase the diversity at EnClear and in the United States Small Business workforce by enabling EnClear Therapies to hire an MS-level engineer who is of Hispanic male descent (a socially disadvantaged person) to contribute to the parent Phase I/II SBIR award supported research. This new employee will contribute to the development and commercialization of a therapeutic device for drug delivery that will improve the quality of life by enabling better distribution of therapeutics for neurological diseases.

PI_NAMEs: GLICKSMAN, MARCIE A (contact)

PROGRAM_OFFICER_NAME: CAPORELLO, EMILY LAURA

PROJECT_TERMS: Address;Administrative Supplement;Antisense Oligonucleotides;Award;Blood - brain barrier anatomy;Businesses;career;Central Nervous System;Cerebral Ventricles;Cerebrospinal Fluid;cerebrospinal fluid flow;commercialization;Development;Devices;Disparity population;Drug Delivery Systems;Employee;Engineering;Frontotemporal Dementia;gene therapy;Hispanic;improved;improved outcome;Individual;Infusion procedures;male;Mind;National Institute of Neurological Disorders and Stroke;Nervous System Disorder;novel;parent grant;Parents;Patient-Focused Outcomes;Patients;Penetration;Pharmaceutical Preparations;Phase;Physiological;Public Health;Pump;Quality of life;Research;Research Support;response;sensor;skills;Small Business Innovation Research Grant;social disparities;System;Therapeutic;Tissues;United States;United States National Institutes of Health

PROJECT_TITLE: Targeted Cerebral Spinal Fluid (CSF) Drug Delivery - Enclear Precision System


ADMINISTERING_IC: AG

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Services;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: ANN ARBOR

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative (Overall) The societal impact of Alzheimer’s Disease and related dementias is broad. In addition to studies that will lead to prevention and cure, we need to develop new knowledge about how health systems, policy makers and communities can address the needs of people at risk for or with these devastating diseases. The proposed Center to Accelerate Population Research in Alzheimer’s will leverage expertise across disciplines to expand and stimulate multidisciplinary studies that will improve outcomes for the growing population with or at risk for AD/ADRD.

PI_NAMEs: BYNUM, JULIE PW (contact)

PROGRAM_OFFICER_NAME: FAZIO, ELENA

PROJECT_TERMS: Acceleration;Address;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Archives;Area;Behavioral Risk Factor Surveillance System;cardiovascular risk factor;Caring;Collaborations;Communities;Complex;Consult;Consumption;cost;Country;Data;Data Sources;Dementia;design;Diffusion;Discipline;Disease;Disparity;Drug Prescriptions;drug quality;Economics;effective therapy;end of life;falls;Funding;Future;Goals;Government;Health;health care delivery;health care service organization;Health Services;Health Services Accessibility;Health system;Healthcare;Home;improved outcome;Individual;Infrastructure;innovation;Institution;Interdisciplinary Study;International;Investigation;Investments;Knowledge;Leadership;Link;Long-Term Care;Medicare;Methods;Michigan;multidisciplinary;National Health and Nutrition Examination Survey;new technology;novel diagnostics;novel therapeutics;organizational structure;Outcome;Personal Satisfaction;Persons;Pilot Projects;Policies;Policy Maker;Population;population based;Population Research;Populations at Risk;Positioning Attribute;prevent;Prevention;Program Development;Public Health;Public Policy;Quality of Care;Ramp;Research;Research Personnel;Research Training;Resource Allocation;Resource Development;Resources;Science;social;Societies;Surveys;System;Time;tool;Training;Universities

PROJECT_TITLE: Center to Accelerate Population Research in Alzheimer's (CAPRA)


NIH_SPENDING_CATS: American Indian or Alaska Native;Clinical Research;Genetics;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Racial and Ethnic Minority Health Research;Rural Health

ORG_CITY: NORMAN

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: UNIVERSITY OF OKLAHOMA

ORG_STATE: OK

PHR: Narrative American Indian and Alaska Native (AI/AN) concerns about genomic research have been well-documented. Failure to engage Tribes about these concerns perpetuates barriers to participation in genomic research. Our center seeks to make progress on these issues through community-led ELSI research and a commitment to training the next generation of leaders in the field, from both the academy and the community.

PI_NAMEs: SPICER, PAUL G (contact)

PROGRAM_OFFICER_NAME: KAUFMAN, DAVE J

PROJECT_TERMS: Academy;Address;Alaska Native;Alaska Native population;American;American Indian Population;American Indians;Area;biobank;Bioethics;Communities;community based participatory research;community engagement;Community of Practice;community partners;community research;Data;Data Collection;Data Set;data sharing;Empirical Research;ethical, legal, and social implication;Ethics;Faculty;Failure;Fellowship Program;Funding;Genomics;Goals;Indigenous;Indigenous American;Infrastructure;Institution;Investments;Journals;Lead;Leadership;Left;Mentors;Modeling;multidisciplinary;National Human Genome Research Institute;next generation;Oklahoma;Population Heterogeneity;Postdoctoral Fellow;precision medicine;Process;programs;Qualifying;racism;Research;Research Methodology;Research Personnel;Research Priority;Resources;Rights;Scholarship;Science;solidarity;Students;Thinking;Training;tribal community;Tribes;United States;Universities;Work

PROJECT_TITLE: Center on the Ethics of Indigenous Genomic Research


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: CINCINNATI

ORG_NAME: UNIVERSITY OF CINCINNATI

ORG_STATE: OH

PHR: Project Narrative CRAC channels are one of the primary Ca2+ influx pathways in nearly all cell types and generate Ca2+ signals critical for many cellular functions. Gain- and loss-of-function mutations in CRAC channel genes lead to diseases in which various tissues and cell types are affected, suggesting diverse physiological and pathophysiological roles CRAC channels play in human health and disease. Here, I present a basic research program to study the molecular regulation of the CRAC channel signaling pathway, which will help uncover the molecular mechanisms underlying the diverse functions of CRAC channels and facilitate development of therapeutics for treating CRAC channel-associated diseases.

PI_NAMEs: HOU, XIAOWEI  (contact)

PROGRAM_OFFICER_NAME: CHAO, CHIEN-CHUNG

PROJECT_TERMS: Address;Affect;Basic Science;Biochemical;Biochemistry;Calcium;Calcium Channel;Calcium Signaling;Cell membrane;Cell Physiology;cell type;Cells;Complex;Cryoelectron Microscopy;Disease;Drosophila genus;Endoplasmic Reticulum;experience;Foundations;gain of function;gain of function mutation;Genes;Goals;Health;Human;human disease;innovation;Ion Channel;Knowledge;Lead;Lipids;loss of function;loss of function mutation;Mammals;Mediating;Membrane;Methods;Molecular;novel;Pathologic;Pathway interactions;Pharmaceutical Preparations;pharmacologic;Physiological;Play;Principal Investigator;programs;protein protein interaction;Proteins;Regulation;Research;response;Role;sensor;Signal Pathway;Signal Transduction;small molecule;STIM1 gene;structural biology;Structure;therapeutic development;Tissues;tool;X-Ray Crystallography

PROJECT_TITLE: Molecular regulation of the CRAC channel signaling pathway


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Obesity;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: LAS VEGAS

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF NEVADA LAS VEGAS

ORG_STATE: NV

PHR: Project Title: Integrating Responsive Feeding and Nutrition Security to Prevent Early Childhood Obesity in Food Insecure Populations. Project Narrative: Despite an increase in the diversity of the United States (US) population, women from an underrepresented race/ethnic minority group remain underrepresented in higher education, particularly in the biomedical research workforce. Childhood obesity has reached epidemic levels, requiring diversifying the workforce who will be researching culturally sensitive approaches to prevent early childhood obesity (ECO) among diverse racial/ethnic and socioeconomic disadvantaged, such as food insecure populations. This diversity supplement application aims to build upon the parent U01 grant to provide mentored research training in community participatory and mixed-methods research for a pre-doctoral and Filipino woman to promote diversity in the field of health disparities in ECO prevention. Letters of Support (Drs. Buccini, Flatt, Sharma, Moonie, Grigsby, Johansen, and Simangan)

PI_NAMEs: BUCCINI, GABRIELA  (contact)

PROGRAM_OFFICER_NAME: CAPPS, RANDOLPH CHRISTOPHER

PROJECT_TERMS: Age;Biomedical Research;Caregivers;Caring;Child;Communities;community based participatory research;Consumption;Data Set;Doctor of Philosophy;early childhood;Epidemic;ethnic minority population;Ethnic Origin;experience;feeding;Fellowship;Filipino;Food;food insecurity;food security;fruits and vegetables;Goals;Grant;health disparity;higher education;Home;Household;improved;Individual;Institution;Intervention;Knowledge;Letters;Manuscripts;Mentors;minority student;Minority-Serving Institution;Nevada;nutrition;obesity in children;obesity prevention;Outcome;parent grant;Parents;Peer Review;Policies;Population;pre-doctoral;prevent;Process;programs;Public Health;Publications;Publishing;racial diversity;racial minority population;Research Methodology;Research Project Grants;Research Training;Risk Assessment;Security;Services;skills;socioeconomic disadvantage;symposium;United States;United States National Institutes of Health;Universities;Woman;Writing

PROJECT_TITLE: Integrating Responsive Feeding and Nutrition Security to Prevent Early Childhood Obesity in Food-Insecure Populations

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(54)-R]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Cancer;Cardiovascular;Heart Disease;Machine Learning and Artificial Intelligence;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: SAN DIEGO

ORG_NAME: VALA SCIENCES, INC.

PHR: FDA guidelines stipulate that all new drugs be tested for dangerous side-effects on the heart as part of preclinical research; however, the current tests are poorly predictive of both dangerous and safe drugs leading to unwarranted attrition and dangerous drugs reaching clinic. Human cardiomyocytes derived from donor tissue (iPSC-derived cardiomyocytes) are widely considered to hold great promise for clinical trial in a dish studies of drug cardiotoxicity. This STTR proposal is to commercialize a high throughput platform to accurately identify drug candidates that have cardiac side effects, in particular adding the ability to detect the type of primary heart cell damage common with anti-cancer drugs in a fully automated (high throughput) robotic assay for the first time, to improve the efficiency of preclinical research and the safety of human clinical trials, which will also likely have the added benefit of reducing animal research.

PI_NAMEs: PRICE, JEFFREY H. (contact)

PROGRAM_OFFICER_NAME: ADHIKARI, BISHOW B

PROJECT_TERMS: Action Potentials;Address;Animal Experimentation;Animal Model;Animal Testing;Animals;Antineoplastic Agents;Arrhythmia;Artificial Intelligence;Biological Assay;Calcium;calcium indicator;cancer recurrence;cancer survival;Cancer Survivor;cancer therapy;cancer type;Cardiac;Cardiac Myocytes;Cardiomyopathies;Cardiotoxicity;cell injury;Cells;cellular imaging;chemotherapy;Clinic;Clinical;clinical trial in a dish;Clinical Trials;commercialization;Complex;Contractile Proteins;cytotoxicity;Dangerousness;detection assay;dosage;Dose;drug candidate;drug discovery;Drug Industry;Guidelines;Heart;heart cell;Heart Diseases;Human;human induced pluripotent stem cells;Image Cytometry;Impairment;improved;In Vitro;induced pluripotent stem cell derived cardiomyocytes;Kinetics;Label;Malignant Neoplasms;Marketing;Measures;Methods;Microscopy;Mitochondria;Motion;novel therapeutics;Pathologic;Pharmaceutical Preparations;Phase;pre-clinical;Pre-Clinical Model;pre-clinical research;Protocols documentation;Research Contracts;response;Robotics;Safety;Sensitivity and Specificity;side effect;Small Business Technology Transfer Research;Speed;Testing;Therapeutic;therapeutic candidate;Time;Tissue Donors;Treatment Side Effects;validation studies;voltage

PROJECT_TITLE: Combined Cardiomyopathy, e.g., of Cancer Chemotherapeutics, and Proarrhythmia for Cardiotoxicity Clinical Trials-in-a-Dish (CTiD) with iPSC-Derived Cardiomyocytes


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Clinical Research;Data Science;Kidney Disease;Networking and Information Technology R&D (NITRD);Patient Safety;Precision Medicine;Prevention

ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: NARRATIVE Chronic kidney disease (CKD) and acute kidney injury (AKI) are common, heterogeneous, and morbid diseases. Mechanistic characterization of CKD and AKI in patients may facilitate a precision-medicine approach to prevention, diagnosis, and treatment. The KPMP aims to ethically and safely obtain kidney biopsies from participants with CKD or AKI; create a reference kidney atlas; characterize disease subgroups to stratify patients based on molecular features of disease, clinical characteristics, and associated outcomes; and identify critical cells, pathways, and targets for novel therapies and preventive strategies.

PI_NAMEs: HIMMELFARB, JONATHAN  (contact);KRETZLER, MATTHIAS

PROGRAM_OFFICER_NAME: GIPSON, DEBBIE SUE

PROJECT_TERMS: Acute Renal Failure with Renal Papillary Necrosis;Address;Atlases;biobank;biomedical informatics;Biometry;Budgets;Cells;Characteristics;Chronic Kidney Failure;Clinical;Clinical Data;Clinical Trials Data Monitoring Committees;Collaborations;collaborative environment;Collection;Communities;community engagement;Community Outreach;Complex;Data;Data Analyses;data curation;data de-identification;data lake;data management;data modeling;data reuse;Data Set;data sharing;Dedications;Diagnosis;Disease;disorder subtype;Ecosystem;Education and Outreach;Ensure;Environment;Epidemiology;equity, diversity, and inclusion;Ethics;experience;FAIR principles;flexibility;Fostering;Funding;Funding Agency;Goals;Human Resources;Image Analysis;improved;Industry;Information Dissemination;Infrastructure;Institutional Review Boards;Kidney;kidney biopsy;Kidney Diseases;Knowledge;Laboratories;Lead;Leadership;Medicine;Metadata;metadata standards;Modeling;Molecular;Monitor;Multicenter Studies;multidisciplinary;National Institute of Diabetes and Digestive and Kidney Diseases;Nephrology;new therapeutic target;Nomenclature;operation;Outcome;Participant;participant enrollment;participant safety;Pathology;Pathway interactions;patient engagement;patient stratification;Patients;Performance;Personnel Management;Phase;Philosophy;precision medicine;Prevention approach;Prevention strategy;Procedures;programs;Protocols documentation;Public Health;Publications;quality assurance;Quality Control;recruit;Reporting;Research;research study;Research Training;Role;Running;Sampling;satisfaction;Science;Scientific Advances and Accomplishments;Secure;Services;Site;software development;Standardization;Structure;success;synergism;System;Systems Biology;Tissue atlas;Tissues;translational approach;web site;website development;Work;working group

PROJECT_TITLE: Central Hub for Kidney Precision Medicine


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Emergency Care;Epilepsy;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurodegenerative;Neurosciences;Pediatric;Prevention;Social Determinants of Health

ORG_DEPT: EMERGENCY MEDICINE

PHR: PROJECT NARRATIVE To provide equitable care for all children experiencing a seizure, we must first understand what inequities exist that may influence the outcomes of children from vulnerable demographic groups and/or communities. By identifying inequities, we can then implement targeted interventions to ensure that all children receive equitable and efficient care regardless of their background or community.

PI_NAMEs: SHAH, MANISH ISHWAR (contact)

PROGRAM_OFFICER_NAME: BROWN, JEREMY

PROJECT_TERMS: Accident and Emergency department;Age;Area;Caring;Child;Child Care;Childhood;Clinical Trials;Communities;demographics;development policy;Disparity population;Dose;Emergency Medicine;Emergency Situation;Equity;experience;Frequencies;Future;Health;health care disparity;Health equity research;health inequalities;Hospital Departments;improved;Individual;Inequity;Intervention;Midazolam;Outcome;parent grant;Patients;pediatric patients;Personal Satisfaction;Pre-hospital setting;Pre-hospitalization care;Principal Investigator;prospective;Research;Risk Factors;Seizures;Service setting;Services;Site;social health determinants;Standardization;Work

PROJECT_TITLE: Pediatric Dose Optimization for Seizures in EMS (PediDOSE)


ORG_DEPT: NEUROSURGERY

PHR: Relevance Disruptions of mitochondrial structure have been found in many neurodegenerative and mitochondrial diseases. An effective treatment is desperately needed but the underlying molecular and cellular mechanisms of their destructive path remain poorly understood. This proposal aims to elucidate the mechanisms underlying mitochondrial strucutral maintenance and provide novel therapeutic strategies to alleviate oxidative damage, is therefore relevant to public health and the mission of the NIH.

PI_NAMEs: WANG, XINNAN  (contact)

PROGRAM_OFFICER_NAME: MILLER, DANIEL L

PROJECT_TERMS: Address;Alzheimer's Disease;Amyotrophic Lateral Sclerosis;ATP Synthesis Pathway;Axon;Behavior;Biochemical;Cells;Charcot-Marie-Tooth Disease;Complex;Crista ampullaris;crista membrane;Disease;Drosophila genus;effective therapy;experimental study;fly;Health;Homeostasis;human disease;Huntington Disease;Impairment;improved;in vivo;Inner mitochondrial membrane;Knowledge;Length;Macromolecular Complexes;Maintenance;Membrane;Metabolic Diseases;Mission;Mitochondria;Mitochondrial Crista;Mitochondrial Diseases;Modification;Molecular;Nerve Degeneration;Neurodegenerative Disorders;Neuronal Dysfunction;Neurons;novel therapeutic intervention;novel therapeutics;Organism;Outcome;oxidation;oxidative damage;Oxidative Phosphorylation;Oxidative Stress;Parkinson Disease;Pathogenicity;Pathologic;Phenotype;Phosphorylation;Physiological;polarized cell;Post-Translational Protein Processing;Proliferating;Public Health;Reaction;Regulation;response;Role;Series;Signal Transduction;Site;stressor;Structure;synaptic function;System;Testing;United States National Institutes of Health

PROJECT_TITLE: Molecular Regulations of Mitochondrial Structure in Neuronal Homeostasis and Survival


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Firearms Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_DEPT: MISCELLANEOUS

PHR: PROJECT NARRATIVE Since 2013, inequities in firearm-related mortality between Black and White children and adolescents ages 1-19 have widened, with the most recent dramatic increases in Black rural youth. This study will apply demographic methods and spatial analysis to examine how area-level structural racism, socioeconomic disadvantage, firearm availability, and population composition contribute to recent spatial and temporal trends in firearm-related mortality among Black youth. The findings will provide critical evidence to guide policymakers in crafting targeted strategies to reduce Black youth firearm-related deaths.

PI_NAMEs: OSYPUK, THERESA LOUISE (contact)

PROGRAM_OFFICER_NAME: CLARK, REBECCA L

PROJECT_TERMS: Adolescent;adolescent health;Age;American;Area;Automobile Driving;Black race;Censuses;Cessation of life;Child;Child Health;Community Surveys;County;Data;Demographic Factors;demographics;Epidemic;Firearms;Goals;Guns;improved;Inequity;innovation;insight;Link;Methods;migration;Minnesota;Modeling;mortality;National Institute of Child Health and Human Development;Ownership;Pattern;Policy Maker;Population;Population Dynamics;Reduce health disparities;residence;Rural;rural area;social factors;socioeconomic disadvantage;spatiotemporal;structural determinants;Structural Racism;Structure;Techniques;Time;Time trend;trend;United States;urban area;Youth

PROJECT_TITLE: Minnesota Population Center


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding

ORG_CITY: LITTLE ROCK

ORG_NAME: UNIV OF ARKANSAS FOR MED SCIS

ORG_STATE: AR

PI_NAMEs: SMELTZER, MARK S (contact)

PROGRAM_OFFICER_NAME: CUPIT, PAULINE

PROJECT_TERMS: Address;Advisory Committees;Applications Grants;Area;Arkansas;Basic Science;career;Center for Translational Science Activities;Centers of Research Excellence;Clinical Sciences;clinically relevant;college;Communicable Diseases;Communication;Development;Development Plans;Disease;Doctor of Philosophy;Ensure;Environment;experience;Extramural Activities;Fostering;Funding;Goals;Grant;Growth;Heart;Immune response;Individual;Inflammatory;Inflammatory Response;Infrastructure;innovation;Institution;Interdisciplinary Study;interest;Laboratories;Lead;Leadership;Letters;Medical;Medicine;meetings;Mentors;microbial;Pathogenesis;Phase;Positioning Attribute;Process;Productivity;Program Development;Program Research Project Grants;programs;recruit;Research;Research Infrastructure;Research Personnel;Resources;Science;Scientist;Seasons;Strategic Planning;Structure;success;Teacher Professional Development;Textiles;Universities;Virulence Factors;Work

PROJECT_TITLE: Core A: Administrative and Scientific Development Core


NIH_SPENDING_CATS: Neurosciences

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Narrative For the brain to function it is essential that large numbers of neurons are interconnected in a highly precise manner, a process which is controlled by the patterns of genes expressed during brain development. Work of this grant focuses on a circuit of the Drosophila brain controlling navigation. We are analyzing connectivity within this circuit with digital connectomes, and use optogenetic tools to record and manipulate neuronal activity in order to develop concepts which are important to understand, and therapeutically manipulate, circuits formed by nerve cells in the human brain.

PI_NAMEs: HARTENSTEIN, VOLKER  (contact);LOUIS, MATTHIEU R. P. J. C. G.

PROGRAM_OFFICER_NAME: OSBORNE, LESLIE CAROL

PROJECT_TITLE: Developmental and functional analysis of neural circuits controlling navigation in Drosophila


ORG_CITY: SEATTLE

ORG_DEPT: UROLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative The aim of the proposed UW Research Site, in conjunction with the Data Coordination Center and existing LURN Research Sites, is to develop and validate urinary symptom-based instruments both in men and women, and to better define the subtypes of men and women with lower urinary tract symptoms. The relevance of the project is to identify subgroups of persons with urinary symptoms, in order to find the causes of the symptoms and identify better treatments.

PI_NAMEs: YANG, CLAIRE C (contact)

PROGRAM_OFFICER_NAME: MULLINS, CHRISTOPHER V

PROJECT_TERMS: Adopted;Clinical;Data Coordinating Center;Diabetes Mellitus;Digestive System Disorders;Finding by Cause;Functional disorder;Guidelines;instrument;Kidney Diseases;Lower urinary tract;lower urinary tract symptoms;Measures;men;Outcome Measure;Participant;Patient Outcomes Assessments;Persons;Protocols documentation;recruit;Request for Applications;Research;Research Personnel;Site;Subgroup;Symptoms;Universities;urinary;Washington;Woman

PROJECT_TITLE: University of Washington LURN II Research Site


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Cardiovascular;Contraception/Reproduction;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hypertension;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PI_NAMEs: KAPLAN, ROBERT  (contact)

PROJECT_TERMS: Acculturation;adjudication;Age Years;Ancillary Study;asthma exacerbation;Award;Cardiac;cardiovascular risk factor;career;Chronic Obstructive Pulmonary Disease;cohort;Communities;Contracts;cultural values;Data Analyses;Diabetes Mellitus;Diagnosis;Disease;Echocardiography;Eclampsia;Education;Ensure;Event;follow-up;Funding;Gestational Diabetes;Health;Health Services Accessibility;Hispanic;Hispanic Community Health Study/Study of Latinos;Hispanic Populations;Hypertension;Individual;innovation;Laboratories;Latino;Left Ventricular Hypertrophy;Length;Medical;Mentorship;Methods;migration;National Heart, Lung, and Blood Institute;Participant;Pre-Eclampsia;Pregnancy;Principal Investigator;programs;protective factors;Protocols documentation;Publications;Reading;Research;Research Personnel;Risk Behaviors;Risk Factors;Services;sociocultural determinant;Socioeconomic Factors;Standardization;Structure;Time;Underrepresented Populations;Visit

PROJECT_TITLE: IGF::OT::IGF Hispanic Community Health Study - Study of Latinos (HCHS-SOL)- Bronx Field Center


ORG_CITY: FREDERICK

ORG_NAME: PRECISION BIOSERVICES, INC.

ORG_STATE: MD

PI_NAMEs: LANGENBACH, KURT  (contact)

PROJECT_TERMS: biobank;National Institute of Diabetes and Digestive and Kidney Diseases;operation;Research;Science

PROJECT_TITLE: THE PURPOSE OF THIS TASK ORDER IS TO MAINTAIN AND ENHANCE THE NIDDK BIOREPOSITORY ROUTINE OPERATIONS TO FACILITATE BIOSPECIMEN UTILIZATION FOR NEW SCIENCE AND BROAD SHARING ACROSS THE RESEARCH COMMUNI


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer

PI_NAMEs: KHOO, PETER  (contact)

PROJECT_TERMS: Agreement;digital;Information Technology;National Cancer Institute;Services

PROJECT_TITLE: NATIONAL CANCER INSTITUTE (NCI)  DIGITAL SERVICES AND SOLUTIONS (DSS) FOUNDATIONAL SUPPORT_CCDI


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Aging;Bioengineering;Clinical Research;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences

ORG_DEPT: BIOMEDICAL ENGINEERING

PHR: PROJECT NARRATIVE Glaucoma is one of the leading causes of irreversible blindness worldwide, and current pharmacologic and surgical treatment methods have low adherence rates and associated complications. The suprachoroidal space can be expanded via a simple microneedle injection of a hydrogel and has been shown to reduce intraocular pressure. In this proposal, I will determine the mechanism of intraocular pressure reduction from suprachoroidal expansion, develop an optimal hydrogel for this application, and evaluate the safety and efficacy of this approach, which will lead to the development of a novel glaucoma treatment method without the use of pharmacologic agents or surgical procedures.

PI_NAMEs: CHUNG, YOOREE GRACE (contact)

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: Adherence;adherence rate;Adverse effects;Affect;Animal Model;Aqueous Humor;Blindness;career;Characteristics;Choroid;Ciliary Muscle;Clinical;Clinical Research;clinical translation;Clinical Trials;Complementary therapies;Data;Development;Disease;Doctor of Philosophy;Drainage procedure;Drug Delivery Systems;Enzymes;Evaluation;experience;Eye;Eyedrops;fabrication;Fellowship;Fibrosis;Formulation;Foundations;Frequencies;Future;Glaucoma;Goals;Health Personnel;Hydrogels;improved;Inflammation;Injections;innovation;interest;Kinetics;Life;Measurement;Measures;medical schools;Mentorship;Methods;Modeling;Muscle Contraction;Needles;non-drug;nonhuman primate;normotensive;novel;novel strategies;Open-Angle Glaucoma;Operative Surgical Procedures;Ophthalmologic Surgical Procedures;optic nerve disorder;optimal treatments;Oryctolagus cuniculus;Outcome;Outpatients;Paper;Pathway interactions;Patient Compliance;Patients;Peer Review;Persons;Pharmaceutical Preparations;pharmacologic;Physiologic Intraocular Pressure;Polymers;Preparation;prevent;Prevention;Procedures;Residencies;Risk;Safety;safety assessment;Scientist;Sclera;side effect;Specialist;success;Surgical complication;Surveys;Techniques;Technology;Tissues;Tracer;Training;translational potential;Translations;treatment adherence;Treatment Efficacy;Treatment outcome;Vision research;Visual;Work

PROJECT_TITLE: A Novel Non-Drug, Non-Surgical Hydrogel-Based Treatment of Glaucoma


NIH_SPENDING_CATS: Clinical Research;Kidney Disease;Organ Transplantation;Prevention;Transplantation

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative Non-functioning kidney grafts after deceased-donor kidney transplantation remain a significant problem, with about one thousand grafts failing yearly and only 50% remain functional after ten years. The current tools we have to predict graft failure are limited in providing pathways for future intervention, therefore this project aims to identify if recipient protein markers involved in blood vessel stability are associated with future graft function in an effort to identify pathways amenable to intervention. The mission of this project aligns well with the overall mission of the NIDDK, as we aim to understand pathways that influence recipient graft outcomes to be able to enhance graft quality and improve overall recipient health.

PI_NAMEs: MANSOUR, SHERRY GEORGE (contact)

PROGRAM_OFFICER_NAME: RANKIN, TRACY L

PROJECT_TERMS: Albumins;Allografting;Angiopoietins;ANGPT1 gene;Animal Model;antagonist;antibody-mediated rejection;Atrophic;Biological;Biological Markers;Biopsy;Blood;Blood capillaries;Blood specimen;Blood Vessels;cadherin 5;career;cell injury;clinical care;clinical epidemiology;Clinical Research;cohort;Collection;Data;Development;Donor person;effective therapy;End stage renal failure;Endothelial Cells;Enrollment;Equilibrium;Evaluation;experience;Extravasation;Family;Fibrosis;Finding by Cause;Folic Acid;follow-up;Future;Glomerular Filtration Rate;Goals;graft failure;graft function;Health;Histologic;Histology;Hospitals;Human;Impairment;improved;Injury;interstitial;Intervention;Intervention Studies;ischemic injury;junctional adhesion molecule;Kidney;kidney allograft;kidney fibrosis;Kidney Transplantation;Learning;Measurement;Measures;Mediator;Mission;Multicenter Trials;National Institute of Diabetes and Digestive and Kidney Diseases;Organ;Organ Procurements;Outcome;participant enrollment;Pathology;Pathway interactions;Patients;Perioperative;Permeability;Plasma;Postoperative Period;Production;prognostic;Prognostic Marker;prospective;Prospective cohort;protein biomarkers;Protocols documentation;Recurrence;Renal function;repaired;Research;response;retransplantation;risk stratification;Role;Sampling;Stains;Structure;Testing;TIE-2 Receptor;Time;Tissue Banks;Tissue Grafts;Tissues;tool;Transplant Recipients;Transplantation;Tubular formation;Urine;Waiting Lists

PROJECT_TITLE: Evaluation of Angiopoietins as Prognostic Markers of Kidney Allograft Structure and Function

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


NIH_SPENDING_CATS: Brain Disorders;Cerebrovascular;Congenital Structural Anomalies;Neurosciences;Pediatric;Prevention;Stroke

ORG_CITY: ATHENS

ORG_DEPT: BIOLOGY

ORG_NAME: OHIO UNIVERSITY ATHENS

PHR: Project Narrative Brain arteriovenous malformation (AVM) is a human neurovascular disorder in which perturbations to vascular cells – including endothelial cells that line the inner lumen of blood vessels – can trigger debilitating blood vessel dysfunction. We previously reported abnormal brain endothelial cell shape, directionality, and movement, using in vitro and in vivo models of endothelial cell dysfunction and brain AVM. We will test the hypothesis that abnormalities to the cytoskeleton underlie brain AVM-related endothelial cell dysfunction and that pharmacological-based normalization of endothelial cell signaling will prevent cytoskeletal anomalies and restore cellular function.

PI_NAMEs: NIELSEN, CORINNE  (contact)

PROGRAM_OFFICER_NAME: UTZ, URSULA

PROJECT_TERMS: Abnormal Endothelial Cell;Address;adrenomedullin;Affect;Blood Vessels;brain abnormalities;brain arteriovenous malformations;brain endothelial cell;Brain hemorrhage;Cell Line;Cell Physiology;Cell Shape;Cells;Central Nervous System;Cessation of life;Chronic disability;Cytoskeletal Modeling;Cytoskeleton;Development;Disease;Endothelial Cells;Endothelium;F-Actin;Functional disorder;Funding;Health;hemodynamics;Human;Impairment;In Vitro;in vivo;in vivo Model;Lead;Metabolic;Molecular;Morphology;Movement;Mus;Nervous System Physiology;neurovascular;parent project;Pathology;pharmacologic;Pharmacological Treatment;polymerization;Polymers;prevent;Reporting;Research;Risk;Signal Transduction;small molecule;small molecule inhibitor;System;Testing;Tissues;United States Food and Drug Administration;vascular abnormality;vascular bed;Vascular System;Work

PROJECT_TITLE: Inhibiting Adrenomedullin signaling to prevent mammalian brain endothelial cell abnormalities and brain arteriovenous malformation


NIH_SPENDING_CATS: Biotechnology;Contraception/Reproduction;Estrogen;Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Women's Health Research

ORG_CITY: DAVIS

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: The proposed research is relevant to public health because defects in germline mechanisms are  responsible for various genetic and epigenetic diseases. This study has high potential  to identify novel epigenetic mechanisms that govern distinct sexually dimorphic processes  in spermatogenesis and oogenesis. The outcome of this study will contribute to significant,  transformative advances in germline biology, and to our understanding of human reproduction and  reproductive health.

PI_NAMEs: NAMEKAWA, SATOSHI  (contact)

PROGRAM_OFFICER_NAME: SALAZAR, DESIREE LYNN

PROJECT_TERMS: Address;Biology;Complement;Complex;Defect;Development;Developmental Process;Disease;DNA Damage;egg;Embryo;Ensure;Epigenetic Process;epigenetic regulation;epigenome;epigenomics;Female;Foundations;Gene Expression;Gene Expression Regulation;Generations;Genetic;Genome;Germ Cells;Germ Lines;Global Change;Human;innovation;Life;Maintenance;male;Meiosis;Mitosis;Molecular;next generation;novel;oocyte maturation;Oogenesis;Outcome Study;Pathway interactions;Positioning Attribute;postnatal;Process;Production;programs;Public Health;Reproduction;Reproductive Health;Research;response;Sex Chromosomes;sexual dimorphism;sperm cell;Spermatocytes;Spermatogenesis;stem cells;therapy development;Work

PROJECT_TITLE: Epigenetic gene regulation in the germline

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


ED_INST_TYPE: HOSPITALS

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: This research project aims to support Samantha Mota, a female graduate student of Latin-American descent, in her studies related to the parent grant “Analgesic signaling in Drosophila”. Preliminary data supporting the parent grant found that AstC-R1, a putative Drosophila receptor for the analgesic effects of opiates, is expressed in nociceptive interneurons. Samantha's related project will explore the exact cellular locus of AstC- R1 analgesic function and related roles for the AstC neuropeptide ligand of this receptor.

PI_NAMEs: GALKO, MICHAEL J (contact)

PROGRAM_OFFICER_NAME: GREENWELL, THOMAS

PROJECT_TERMS: Absence of pain sensation;Acids;Acute;Analgesics;Animals;antinociception;Area;Automobile Driving;base;Basic Science;Behavioral;behavioral response;Binding;Biochemical;Biological;Biological Assay;Biology;Calcium;Candidate Disease Gene;career;Cells;Chemicals;clinical practice;Constipation;Data;Dedications;design;Dose;Drosophila genus;Educational process of instructing;Exhibits;experimental study;Exposure to;Female;Fentanyl;fighting;fly;Funding;Future;G Protein-Coupled Receptor Signaling;G-Protein-Coupled Receptors;gene conservation;gene discovery;Genes;Genetic;genetic analysis;genetic approach;Goals;graduate student;Grant;Hand;Health;health practice;High temperature of physical object;Human;Image;improved;Injury;Institution;Interneurons;Ion Channel;Larva;Latin American;Ligands;Mechanics;Mediating;Mediator;minority undergraduate;Modality;model organism;Modeling;Molecular;Morphine;morphine administration;Morphine Receptors;morphine tolerance;National Institute of Neurological Disorders and Stroke;Neurons;Neuropeptides;Nociception;nociceptive response;Opioid;Opioid Peptide;Opioid Receptor;Organism;Orthologous Gene;Pain;Paper;parent grant;Parents;Pathway interactions;Peptides;Peripheral;Phenotype;Physiological;Population;Qualifying;receptor;receptor binding;Reporter;Research;Research Project Grants;response;Role;role model;Scientist;Sensory;side effect;Signal Pathway;Signal Transduction;skills;somatostatin receptor 2;Stimulus;System;Testing;tissue injury;Tissues;Touch sensation;Training;United States National Institutes of Health;Vertebrates;Video Microscopy;Withdrawal;Work

PROJECT_TITLE: Analgesic Signaling in Drosophila

STUDY_SECTION: NPI

STUDY_SECTION_NAME: Neurobiology of Pain and Itch Study Section [NPI]


NIH_SPENDING_CATS: Clinical Research;Maternal Health;Pediatric;Pregnancy;Women's Health Research

ORG_CITY: Newark

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: PROJECT NARRATIVE This is a request to support Michael Campbell through a “Supplement to Promote Diversity in Health-Related Research” (PA-23-189), under Lauren Aleksunes’ (PI) award UC2HD113039. Michael Campbell is a predoctoral fellow in the Joint Graduate Program in Toxicology at Rutgers University. The studies outlined in this proposal will extend the parent grant to elucidate the specific OATP placental isoforms responsible for uptake of the harmful algal bloom toxin, microcystin, as well as evaluate 3D placental spheroids as a translational model for placental xenobiotic uptake.

PI_NAMEs: ALEKSUNES, LAUREN M (contact);HUH, DONGEUN ;ZHU, HAO

PROGRAM_OFFICER_NAME: WEINBERG, DAVID H

PROJECT_TERMS: 3-Dimensional;Acceleration;Active Biological Transport;ATP-binding cassette transport;ATP-Binding Cassette Transporters;Award;Biology;Biomedical Engineering;Birth;career;Chemicals;cohort;Computational Biology;Computer Models;Data;Data Set;dietary supplements;Discipline of obstetrics;doctoral student;drug disposition;Ensure;Epidemiology;fetal;Fetal Development;Fetus;Genetic;Goals;harmful algal blooms;Health;Healthcare;improved;inhibitor;innovation;Institution;Joints;Maternal Health;Maternal-fetal medicine;microcystin;microphysiology system;Modeling;novel;novel strategies;Nutrient;parent grant;perinatal health;Pharmaceutical Preparations;Pharmacology;Pharmacotherapy;Placenta;Postdoctoral Fellow;pre-doctoral;Pregnancy;programs;Property;Protein Isoforms;Proteomics;Public Health;Regulation;Research;Resources;Scientist;solute;spheroids;System;Testing;Therapeutic;Therapeutic Intervention;toxicant;Toxicology;Toxin;Training;training opportunity;translational model;Translational Research;trophoblast;undergraduate student;Universities;uptake;Xenobiotics

PROJECT_TITLE: Diversity Supplement to Integrated Transporter Elucidation Center


ADMINISTERING_IC: OD

FUNDING_MECHANISM: OTHERS

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Data Science;Genetics;Human Genome

PI_NAMEs: MA'AYAN, AVI  (contact)

PROGRAM_OFFICER_NAME: KUKKE, SAHANA NALINI

PROJECT_TERMS: Address;Adoption;Affect;Archives;Automobile Driving;Biological Assay;Biomedical Research;Cell Survival;Cells;Collection;Communities;Complex;computing resources;Data;Data Commons;data ecosystem;data harmonization;data integration;data visualization;Databases;Dimensions;Disease;drug discovery;Educational process of instructing;Ensure;Environment;epigenomics;FAIR principles;Funding;gene regulatory network;Genes;Genotype-Tissue Expression Project;Human;human data;Image;improved;Intuition;knock-down;Knock-out;Libraries;Link;Metadata;Molecular;Monitor;Network-based;online resource;Online Systems;overexpression;Paper;patient subsets;Patients;Pharmaceutical Preparations;Physicians;Pilot Projects;pre-clinical;Process;programs;Proteomics;Publications;Research;Resources;response;Sampling;side effect;Signal Transduction;small molecule;small molecule libraries;statistics;Therapeutic;Time;tool;transcriptome sequencing;transcriptomics;treatment response;United States National Institutes of Health;Visit;Visualization

PROJECT_TITLE: The LINCS DCIC Engagement Plan with the CFDE


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Dementia;Frontotemporal Dementia (FTD);Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: SAN FRANCISCO

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE The neurobiological basis of socioemotional symptoms, a debilitating feature of many neurological and psychiatric disorders, is not well understood. The brain and autonomic nervous system cohesively interact to support socioemotional well-being, and cutting-edge analytical techniques can now reveal the rich dynamic properties of these systems. By leveraging behavioral variant frontotemporal dementia, a neurodegenerative disease of socioemotional deficits that targets these systems, the goal of the proposed project is to determine how autonomic and functional brain network dynamics shape human emotions and social behavior in healthy and clinical populations.

PI_NAMEs: PASQUINI, LORENZO  (contact)

PROGRAM_OFFICER_NAME: SUTTERER, MATTHEW

PROJECT_TERMS: Affective Symptoms;Aging;aging population;Algorithms;Applications Grants;Area;Arousal;Autonomic nervous system;Award;Behavioral;behavioral variant frontotemporal dementia;Biometry;Brain;Brain region;Breathing;California;career;Clinical;comparison control;Computing Methodologies;Data;data acquisition;Dementia;Deterioration;Diagnostic;Disease;dynamic system;Educational Status;Elderly;Emotional;emotional functioning;emotional symptom;Emotions;Empathy;Exhibits;fundamental research;Future;Galvanic Skin Response;geriatric neuropsychiatry;Goals;Health;healthy aging;Human;Image;Impairment;improved;innovation;Lesion;Link;Machine Learning;machine learning algorithm;Magnetic Resonance Imaging;Maps;Memory;Mental disorders;Mentors;Mentorship;Modeling;Mood Disorders;Moods;multimodal data;multimodality;Nerve Degeneration;Nervous System Disorder;network dysfunction;neural;neural correlate;Neuroanatomy;Neurobiology;Neurodegenerative Disorders;neuroimaging;Neurologist;neuromechanism;Neurons;Neurosciences;older adult;Pathway interactions;Patients;Phase;Physiological;Physiology;Pilot Projects;Play;Population;Postdoctoral Fellow;Productivity;programs;Property;Psychiatry;Psychologist;recruit;Regulation;Research;Research Personnel;Rest;Role;Running;Sampling;San Francisco;Scanning;Series;Severities;Shapes;skills;Social Behavior;Syndrome;System;Techniques;Time;Training;Universities;Virginia;Well in self;Work

PROJECT_TITLE: Dynamic neural systems underlying socioemotional function


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Prevention

PHR: PROJECT NARRATIVE The number of individuals with clinical Alzheimer's disease (AD) is rapidly increasing worldwide due to aging of the population, but current cognitive measures lack sufficient sensitivity and specificity to detect subtle decline within the preclinical phase. There is a critical need for tools that are sensitive to AD neuropathology during the preclinical phase that are low-cost, high-access, and fast to administer that can be used across educationally, linguistically, and culturally diverse older individuals. The goal of this project is to identify metrics for semantic impairment in diverse individuals that correlate with AD neuropathology and predict clinical decline.

PI_NAMEs: VONK, JET M.J. (contact)

PROJECT_TERMS: Adult;Age;age effect;Aging;Alzheimer's Disease;Alzheimer's disease diagnosis;Amyloid;Amyloid beta-Protein;Animals;apolipoprotein E-4;Area Under Curve;autosome;Biological Markers;Black race;Canis familiaris;Caregivers;Categories;Clinical;clinical diagnosis;clinical predictors;Clinical Research;Cognitive;cognitive testing;cohort;cost;Data;Dementia;Demographic Factors;demographics;Diagnosis;diagnostic accuracy;early detection biomarkers;Early Diagnosis;Education;Epidemiology;Episodic memory;Equation;Ethnic Origin;Ethnic Population;experience;Foundations;Frequencies;Gender;gender difference;Genes;Goals;Hippocampus;Hispanic;Iguanas;imaging biomarker;Impairment;Individual;Inherited;Intervention;Intervention Trial;Investigation;Knowledge;Language;Length;lexical;Linear Models;Linguistics;Longitudinal cohort;Magnetic Resonance Imaging;Maps;Measures;Medial;Memory impairment;Modeling;mutation carrier;Names;neuroimaging marker;neuropathology;Neuropsychology;non-demented;normal aging;novel;older adult;Older Population;Outcome;Parietal;Participant;Patients;Performance;Persons;Phase;Population;Positron-Emission Tomography;pre-clinical;Predictive Value;Process;prognostic model;programs;Psycholinguistics;Race;racial population;Research;Semantic memory;semantic processing;Semantics;Sensitivity and Specificity;sex;Spanish;Specificity;Statistical Data Interpretation;Symptoms;Testing;Thinness;Time;tool;Training;trait;Translating;Universities;Variant;Walking;Work

PROJECT_TITLE: Preclinical markers of Alzheimer's disease using psycholinguistic semantic measures


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Eye Disease and Disorders of Vision;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric

ORG_CITY: DE KALB

ORG_NAME: NORTHERN ILLINOIS UNIVERSITY

ORG_STATE: IL

PHR: Project Narrative This project examines how school-age blind children acquire word meanings, and whether the trajectory of vocabulary development in blind children is altered or delayed relative to that in typically sighted children. Findings from this research have the potential to improve instructional approaches and language and literacy interventions for blind children.

PI_NAMEs: HARRIS, LINDSAY NICOLE (contact)

PROGRAM_OFFICER_NAME: WIGGS, CHERI

PROJECT_TITLE: Word Learning and Vocabulary Development in Blind Children


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Pediatric;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human;Stem Cell Research - Nonembryonic - Non-Human;Temporomandibular Muscle/Joint Disorder (TMJD)

ORG_CITY: Los Angeles

ORG_DEPT: ORTHOPEDICS

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Birth defects and skeletal diseases affecting the skull and jaw are a major societal burden. We propose to use zebrafish, a highly regenerative vertebrate amenable to powerful genetic and imaging techniques, to understand how stem cells build and then maintain and repair the head skeleton. The long-term goal is to use foundational knowledge acquired in the zebrafish to develop new regenerative medicine treatments for human craniofacial diseases.

PI_NAMEs: CRUMP, GAGE D (contact)

PROGRAM_OFFICER_NAME: SAIFUDEEN, ZUBAIDA

PROJECT_TERMS: Adult;Affect;Arthritis;arthropathies;Award;bone;California;career;Cartilage;Cells;Congenital Abnormality;craniofacial;craniofacial development;craniofacial repair;craniofacial tissue;cranium;Development;Disease;Doctor of Philosophy;Economics;endogenous stem cells;Face;Faculty;Fellowship;Fishes;Funding;Future;gene editing technology;Genes;Genetic;Genetic Techniques;Goals;Head;healing;high school;Human;human model;Image;Imaging Techniques;improved;Industry;Injury;innovation;Jaw;Joints;Knowledge acquisition;Maintenance;man;member;Mentors;Microscopy;Modeling;Mus;National Institute of Dental and Craniofacial Research;Natural regeneration;notch protein;novel;Patients;Pattern;Population;Positioning Attribute;Postdoctoral Fellow;Privatization;progenitor;programs;Publishing;recruit;regenerative;regenerative approach;Regenerative Medicine;Regulation;repaired;Research;Research Personnel;Resources;Role;Science;Signal Transduction;skeletal;skeletal disorder;Skeleton;stem cell biology;Stem Cell Research;stem cells;Surgical sutures;Temporomandibular Joint;tenure track;underrepresented minority student;Universities;Work;Zebrafish

PROJECT_TITLE: Progenitor Regulation in Craniofacial Development and Regeneration


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Chronic Pain;Machine Learning and Artificial Intelligence;Neurosciences;Pain Research

ORG_CITY: PISCATAWAY

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: RUTGERS, THE STATE UNIV OF N.J.

PHR: Intrathecal oxytocin is in clinical trials as an opioid alternative for chronic pain treatment. Our work in mice suggests that coupling intrathecal oxytocin with manual therapies (i.e. massage) optimizes the analgesic properties of oxytocin. This project provides the framework to support this combination therapy by concentrating on the spinal cord circuit mechanisms by which oxytocin alleviates pain.

PI_NAMEs: ABRAIRA, VICTORIA EUGENIA GUADALUPE (contact)

PROJECT_TERMS: Absence of pain sensation;Affective;Analgesics;Animals;Anterolateral;autistic children;Behavior;Behavior Therapy;Behavioral;Behavioral Assay;behavioral study;Biological Assay;Brain;brain circuitry;Chronic;chronic pain management;Clinic;Clinical Trials;Combined Modality Therapy;Computer Vision Systems;Coupling;Data;differential expression;Dimensions;Dissection;dorsal horn;dosage;efficacy evaluation;Electrophysiology (science);emotional experience;experience;experimental study;Female;genetic approach;Histologic;Human;human tissue;Image;injured;innovation;Interneurons;Learning;Machine Learning;male;Manipulative Therapies;Maps;Massage;Mechanoreceptors;Mediating;Methods;Modeling;Molecular;Morphology;Motivation;Mus;National Institute of Neurological Disorders and Stroke;Negative Valence;Nervous System;Neuromodulator;Neurons;Neuropeptides;Nociception;Nociceptors;novel;novel therapeutics;Opioid;Output;Oxytocin;Oxytocin Receptor;Pain;Pain Measurement;Peripheral;pharmacologic;Pharmacology Study;Physiology;Positive Valence;pre-clinical;Preparation;Property;Rattus;receptor;receptor expression;Reflex action;Reproducibility;Research;Resource Sharing;response;Rodent;Rodent Model;Sensory;sensory stimulus;Shapes;Signal Transduction;Skin;Social Behavior;Social Interaction;social learning;Spinal;Spinal Cord;Standardization;Stimulus;Synapses;System;Techniques;Testing;tool;Touch sensation;Translating;two-photon;Work

PROJECT_TITLE: NINDS Diversity Supplement-Ms. Lucero Shorter


ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: PROJECT NARRATIVE Proper cell shape control is essential for the proliferation of cells, normal development and maintenance of a healthy organism. We study how cytokinesis, the physical process in which one cell splits into two, works at a fundamental level in order to understand how cells control cell shape more generally. Ultimately, with a rigorous understanding and a complete molecular handle on these processes, it should be possible to develop better therapies that are tailored to the properties of specific disease types.

PI_NAMEs: ROBINSON, DOUGLAS N (contact)

PROGRAM_OFFICER_NAME: MILLER, RITA K

PROJECT_TERMS: Actins;Actomyosin;Adenine Nucleotide Translocase;Affinity;Area;Binding;Biochemical;Biological Assay;Biology;Biomechanics;Bypass;cell behavior;cell cortex;Cell model;Cell Physiology;Cell Proliferation;Cell Shape;Cells;cellular imaging;Chemicals;Clustered Regularly Interspaced Short Palindromic Repeats;Collection;Colorectal Cancer;Complex;cortexillin I;Crosslinker;crosslinking and immunoprecipitation sequencing;Cytokinesis;Cytoplasm;Cytoprotection;Cytoskeletal Proteins;Cytoskeleton;Data;daughter cell;Development;Dictyostelium;Dictyostelium discoideum;Diffusion;Disease;Endowment;Engineering;Environmental Hazards;Exposure to;Feedback;Filament;Fluorescence;follow-up;Gene Expression;Genetic;Grant;Hepatocyte;Human;In Vitro;in vivo;individualized medicine;KIT gene;knock-down;Lectin;Length;Life;Link;Liquid substance;Lung;Maintenance;Malignant neoplasm of pancreas;Mammalian Cell;Maps;Measurement;Mechanical Stress;Mechanics;Messenger RNA;Metabolic;Metabolism;Microtubules;Molecular;mRNA Stability;mutant;Myoblasts;Myosin Type II;Nocodazole;Organism;Outcome;overexpression;Oxidative Phosphorylation;Pathway interactions;Phenotype;physical process;Process;Production;Property;Protein Secretion;Proteins;Proteomics;Race;reconstitution;Ribonucleoproteins;RNA;RNA Recognition Motif;RNA-Binding Proteins;Role;Signal Transduction;single molecule;Site;small molecule;Spectrum Analysis;stoichiometry;Surface;Surveys;System;Techniques;Transcript;transcriptome sequencing;viscoelasticity;Work

PROJECT_TITLE: The Biochemical Basis for the Mechanics of Cytokinesis

STUDY_SECTION: NCSD

STUDY_SECTION_NAME: Nuclear and Cytoplasmic Structure/Function and Dynamics Study Section[NCSD]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Cerebrovascular;Dementia;Lewy Body Dementia;Neurodegenerative;Neurosciences;Parkinson's Disease

ORG_CITY: BAYAMON

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSIDAD CENTRAL DEL CARIBE

ORG_STATE: PR

PHR: PROJECT NARRATIVE: Parkinson’s disease (PD), late PD dementia (PDD), and PD-related amyloid angiopathy are looming disasters for public health. The combined direct and indirect cost of PD, including treatment, social security payments, and lost income, is estimated to be nearly $52 billion per year in the United States alone. Nearly 1 million Americans are living with PD (2020), and the numbers are growing, as there is no definitive cure. This proposed research is highly relevant, as the control of systemic β-amyloid peptide production and transport, involving platelets and blood, could slow the advance of late-stage dementia and open up a new approach to therapy.

PI_NAMEs: INYUSHIN, MIKHAIL  (contact)

PROGRAM_OFFICER_NAME: BERNAL, FEDERICO

PROJECT_TERMS: abeta accumulation;abeta oligomer;Abeta synthesis;Affect;Alzheimer's Disease;American;Amyloid;Amyloid beta-Protein;Amyloidosis;anti-microbial drug;antimicrobial;Antiplatelet Drugs;Apolipoproteins;Area;artery occlusion;Autoimmunity;Biochemistry;Biology;Blood;Blood Platelets;Blood Vessels;Brain;brain cell;Brain Neoplasms;brain tissue;Cells;Cerebral Amyloid Angiopathy;Cerebral Thrombosis;Cerebrovascular system;Cerebrum;Chemicals;Coagulation Process;Collaborations;Corpus striatum structure;Data;debilitating symptom;Dementia;density;Development;Direct Costs;Disasters;Disease;disease model;Dopamine;dopaminergic neuron;Encephalitis;experience;experimental study;Facilities and Administrative Costs;frontal lobe;Goals;Hour;immunocytochemistry;Immunofluorescence Immunologic;Impaired cognition;Income;Infectious Agent;Inflammation;Injury;innovation;Lead;Lesion;Membrane;meter;Midbrain structure;motor impairment;mouse model;Mus;natural antimicrobial;Natural Immunity;Neurofibrillary Tangles;neuropathology;novel strategies;novel therapeutics;Oxidopamine;Parkinson Disease;Parkinson's Dementia;Pathogenesis;Patients;payment;Peptides;Physiology;Plasma;Platelet Activation;Platelet Count measurement;Prealbumin;Process;Production;Public Health;Publishing;Qualifying;Research;Role;Senile Plaques;Site;Skin;Slice;Social Security;Source;Specialist;Substantia nigra structure;synucleinopathy;tau aggregation;Testing;Therapeutic;Thrombosis;thrombotic;Time;Tissues;United States

PROJECT_TITLE: Build-up of beta-amyloid in the brain in Parkinson's disease


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Neurosciences;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: BLACKSBURG

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

ORG_STATE: VA

PHR: PROJECT NARRATIVE Limited information exists pertaining to the physiological relevance of innate immune regulation across the age spectrum following TBI. Completion of these studies will advance our understanding of the key regulators involved in monocyte/macrophage responses and neurovascular health in TBI pathophysiology. Exploiting the pro-resolving phenotype of juvenile- derived PDMs may provide a novel restorative intervention aimed at improving TBI outcomes and reveal novel targets for drug discovery.

PI_NAMEs: THEUS, MICHELLE LEE (contact)

PROGRAM_OFFICER_NAME: AWWAD, HIBAH OMAR

PROJECT_TERMS: Acceleration;Acute;Adolescent;Adult;Affect;Age;age difference;age related;age related changes;aged;Attenuated;Behavior;Behavioral;behavioral outcome;behavioral phenotyping;Biochemical;Blood - brain barrier anatomy;Blood brain barrier dysfunction;Blood Vessels;Brain Injuries;Cells;central nervous system injury;Cerebrovascular Circulation;Chronic;Data;disability;drug discovery;Endothelial Cells;EphA4 Receptor;epigenomics;Female;Functional disorder;functional outcomes;genome-wide;genome-wide analysis;Goals;Health;Hippocampus;Histologic;IL4 gene;Immune;Immunologics;immunoregulation;improved;In Vitro;in vivo;Infiltration;Inflammation;Inflammatory;inflammatory milieu;Injury;innovation;Intervention;Lesion;Macrophage;male;Mediating;Microglia;Molecular;monocyte;mouse model;Mus;neuroinflammation;neuron loss;neuroprotection;neurotoxic;neurovascular;neurovascular injury;neutrophil;new therapeutic target;novel;novel strategies;Outcome;Pathogenesis;Pathogenicity;Patients;Peripheral;Phagocytes;pharmacologic;Phenotype;Physiological;porcine model;postnatal;pre-clinical;preclinical study;Process;protective effect;Publishing;Receptor Cross-Talk;Recovery;Recovery of Function;repaired;Reporter;Research;response;response to injury;restoration;Rodent Model;Role;Technology;Testing;Time;Tissues;tool;transcriptomics;Transgenic Mice;Transgenic Organisms;Traumatic Brain Injury;Traumatic Brain Injury recovery

PROJECT_TITLE: Chronic behavioral outcome and neuroinflammatory consequences of TBI

STUDY_SECTION: BINP

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Prevention;Social Determinants of Health

ORG_CITY: FULLERTON

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: CALIFORNIA STATE UNIVERSITY FULLERTON

PHR: PROJECT NARRATIVE Brain-related aging and health, including Alzheimer's disease and related dementia (ADRD) have a profound impact on individual physical and mental functioning, and also on families and society. Therefore, investigation of neurocognitive aging and ADRD is crucial to our society and the individuals within it; however, we have too few trained underrepresented scientists to address the challenges of neurocognitive aging and ADRD faced by our increasingly diverse aging population. Our project will develop an exhaustive research training experience in neurocognitive aging ranging from basic neurobiology of neurodegenerative conditions, modifiable risk factors and health disparities related to neurocognitive aging, which will subsequently establish a talented, committed, and sustained pipeline of underrepresented students reflective of community demographics, who have unique perspectives, capable of addressing critical neurocognitive aging challenges in our changing world.

PI_NAMEs: BRASKIE, MEREDITH NICOLE;MCELIGOT, ARCHANA J (contact);TOGA, ARTHUR W

PROGRAM_OFFICER_NAME: LUO, YUAN

PROJECT_TERMS: Address;African American population;age related;age-related disease;Aging;aging brain;aging population;aging related;Alaskan;Alzheimer's disease related dementia;American;Area;Basic Science;Biomedical Research;Brain;brain health;career;career preparation;Cell Physiology;Censuses;Clinical Research;Clinical Trials;cohort;Communities;comparative;Competence;Computer Analysis;curriculum development;Data;Data Science;Degenerative Disorder;demographics;disadvantaged student;Disparity;Economics;Education;education research;Educational Curriculum;Educational workshop;Effectiveness;Enrollment;Ensure;Environmental Risk Factor;epidemiology study;ethnic diversity;ethnic health disparity;ethnic minority;Ethnic Population;Evaluation;evidence base;experience;Face;Faculty;faculty mentor;Family;Female;Funding;Future;Generations;Genetic Processes;genetic risk factor;Goals;graduate school;graduate school preparation;GRE Preparation;hands on research;Health;health disparity;health equity;Health equity research;Health Professional;health training;human old age (65+);Impaired cognition;improved;Individual;innovation;insight;interest;Investigation;Knowledge;Latino Population;Letters;male;meetings;mental function;Mentors;Mentorship;Minority;minority undergraduate;modifiable risk;Molecular;Multimedia;Native Americans;Nerve Degeneration;Neurobiology;Neurocognitive;neuroimaging;Neurosciences;next generation;Oral;Participant;Physical Function;Population;Population Heterogeneity;Population Research;Process;programs;racial diversity;racial minority;Readiness;Research;Research Methodology;Research Personnel;Research Training;Risk Factors;role model;Science;Scientist;Site Visit;skills;Social Environment;Societies;Statistical Data Interpretation;Students;success;Talents;Training;undergraduate student;Underrepresented Minority;Underrepresented Populations;Underrepresented Students;United States;Universities;Vulnerable Populations;Writing

PROJECT_TITLE: Neurocognitive Aging & Analytics Research Education (NAARE)


NIH_SPENDING_CATS: Aging;Bioengineering;Brain Disorders;Clinical Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Parkinson's Disease

ORG_NAME: HUGO W. MOSER RES INST KENNEDY KRIEGER

PHR: Project Narrative Parkinson’s disease (PD) often results in widespread motor dysfunction. PD is a progressive and degenerative condition, and thus frequent and granular assessment of motor function is critical to effective management of motor symptoms. In this proposal, we will use an innovative pose estimation approach to enable objective quantification of many motor features of PD using only simple digital videos that can be recorded from common household devices (e.g., smartphones, tablets, laptop computers).

PI_NAMEs: ROEMMICH, RYAN THOMAS (contact)

PROGRAM_OFFICER_NAME: AJISAFE, TOYIN DELE

PROJECT_TERMS: Algorithms;Artificial Intelligence;Cellular Phone;Clinic;Clinical;Communities;Computer Vision Systems;Computers;cost;Data;Degenerative Disorder;Development;Devices;digital;digital video recording;Emerging Technologies;Equipment;Fingers;Gait;Gait abnormality;Home;Household;Human;innovation;kinematics;laptop;Measurement;Methods;Motion;Motor;motor deficit;motor disorder;motor symptom;Movement;Movement Disorder Society Unified Parkinson's Disease Rating Scale;Movement Disorders;Nature;Nerve Degeneration;Neurologist;novel strategies;Parkinson Disease;Persons;Process;Research;Series;Tablets;Technology;Testing;Time;Visual

PROJECT_TITLE: An automated approach for video-based motor assessment in Parkinson's disease


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Biotechnology;Childhood Injury;Congenital Structural Anomalies;Genetics;Pediatric;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human;Unintentional Childhood Injury

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: NARRATIVE  The proposed research is focused on understanding the mechanism of Hox function in regulating skeletal differentiation. Loss of Hox function impacts the ability of skeletal stem/progenitors to complete differentiation down the osteogenic and chondrogenic lineages via unknown pathways. The conserved, region-specific, expression of Hox genes in the skeletal stem/progenitors (MSCs) in all vertebrates, including humans, supports the significance and relevance of these studies and fulfills the mission and goal of the NIH to understand the processes of human growth and development.

PI_NAMEs: WELLIK, DENEEN M (contact)

PROGRAM_OFFICER_NAME: PINTUCCI, GIUSEPPE

PROJECT_TERMS: Address;Adipocytes;Adult;Alleles;Animal Model;Animals;Apoptosis;Binding;Binding Sites;Biology;Biometry;bone;bone fracture repair;Bypass;Candidate Disease Gene;Cartilage;Cell Culture Techniques;Cell Differentiation process;Cells;Chondrocytes;Chondrogenesis;Chromatin;Cleavage Under Targets and Release Using Nuclease;Collection;comparative;conditional mutant;Control Animal;Data;Defect;Differentiation Antigens;differentiation in vitro;Embryo;Embryonic Development;Epitopes;Event;experimental study;Forelimb;Fracture;Gene Expression Profiling;gene function;Genes;Genetic;Genomics;Goals;Growth;Growth and Development function;Homeobox Genes;Homeostasis;Human;In Vitro;in vivo;Injury;innovation;Knock-in;Knowledge;Label;Laboratories;Life;loss of function;Maps;Mediating;Mission;Modeling;Molecular;morphogens;Morphology;Mus;mutant;Osteoblasts;Osteocalcin;Osteocytes;Osteogenesis;osteogenic;osteopontin;Pathway interactions;Pattern;Phenotype;Play;Population;Positioning Attribute;Process;progenitor;Publishing;Radial;Regulation;repaired;Reporter;Reporting;Research;Research Personnel;Research Proposals;Resolution;response to injury;Role;self-renewal;Site;skeletal;Skeletal Development;skeletal stem cell;Skeleton;stem;stem cells;Testing;Time;Tissue-Specific Gene Expression;tool;transcription factor;transcriptomics;ulna;United States National Institutes of Health;unsupervised clustering;Vertebrates;virtual;Visualization;Work

PROJECT_TITLE: Hox-Regulated MSCs in Skeletal Development, Growth and Fracture Healing

STUDY_SECTION: SBDD

STUDY_SECTION_NAME: Skeletal Biology Development and Disease Study Section[SBDD]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Lewy Body Dementia;Neurodegenerative;Neurosciences;Parkinson's Disease

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative This supplement project will develop methods to measure specific protein components in the cerebrospinal fluid of people with Parkinson disease (PD), and determine whether these measurements correlate with the development of cognitive impairment and other symptoms that occur with disease progression. These types of biomarker measurements are needed to guide the development of treatments for PD. The supplement project will also support the career development of an investigator developing expertise in biomarkers for PD.

PI_NAMEs: KOTZBAUER, PAUL T (contact)

PROGRAM_OFFICER_NAME: SWANSON-FISCHER, CHRISTINE R

PROJECT_TERMS: Affect;alpha synuclein;Autopsy;Biological Markers;brain tissue;career development;Cell Nucleus;Cerebrospinal Fluid;Clinical;Cognitive;Cross-Sectional Studies;Data;Dementia;Development;Diffuse;Disease;disease prognosis;Disease Progression;Effectiveness;Funding;Immunoassay;Impaired cognition;Impairment;interest;Lewy Bodies;Liquid Chromatography;Longitudinal Studies;Manuscripts;Measurement;Measures;Methods;Monitor;Motor;motor symptom;neocortical;Neurobehavioral Manifestations;neurobiological mechanism;Neurodegenerative Disorders;Neurons;Neurotransmitters;non-motor symptom;noradrenergic;novel;Parkinson Disease;Parkinson's Dementia;Participant;Persons;Presynaptic Terminals;protein aggregation;Proteins;psychiatric symptom;Research Personnel;single molecule;Symptoms;Synapses;Therapeutic;therapeutic target;therapy development;Tissue Sample

PROJECT_TITLE: Protein Aggregation and Neurotransmitter Deficits in Parkinson Disease

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Neurosciences;Sleep Research

ORG_CITY: COLLEGE STATION

ORG_NAME: TEXAS A&M UNIVERSITY

PHR: Successful completion of the proposed experiments will characterize the role of astrocytic molecular clock in regulating synaptic development and establishment of synaptic rhythmicity and cognitive performance. There is a strong comorbidity between disruptions to the circadian cycle, and cognitive impairments, yet the mechanistic link is not well understood. We will examine how developmental perturbation to astrocytic molecular clock regulates time-of-day-dependent changes in synapse number and activity, and underlying behavior.

PI_NAMEs: FARHY, ISABELLA  (contact)

PROGRAM_OFFICER_NAME: TYLER, WILLIAM A

PROJECT_TERMS: Address;Adult;Affect;Alzheimer's Disease;AMPA Receptors;Area;ARNTL gene;Astrocytes;autism spectrum disorder;Behavior;Brain;Brain region;Calcium;Calcium Signaling;cell type;chordin;Chronic;circadian;Circadian Dysregulation;circadian pacemaker;Cognition;Cognition Disorders;Cognitive;Cognitive deficits;cognitive function;cognitive performance;comorbidity;Data;Development;differential expression;Disease;Eating;epidemiology study;Exhibits;experimental study;Functional disorder;Future;Genes;Genetic;Glutamates;Glypican;Harvest;Health;Hippocampus;Human;Hypothalamic structure;Impaired cognition;in vivo;Investigation;Knockout Mice;Knowledge;Learning;Life;Life Style;Light;Link;Maintenance;Mass Spectrum Analysis;Mediating;Memory;Memory impairment;memory process;Mental Depression;Modernization;Molecular;molecular clock;Mus;Nature;Nervous System Disorder;Neuroglia;Neurons;novel;Periodicity;Peripheral;Persons;Population;Prevalence;Process;Production;Prosencephalon;Protein Secretion;Proteins;Proteome;Publishing;receptor expression;Regulation;Research;Role;shift work;Sleep;Sleep disturbances;sleep pattern;Stress;suprachiasmatic nucleus;Synapses;synaptic function;synaptogenesis;Testing;Time;Travel;Work

PROJECT_TITLE: Regulation of Synaptic Rhythmicity by Astrocytic Clock


NIH_SPENDING_CATS: Neurosciences

ORG_CITY: EDINBURG

ORG_NAME: UNIVERSITY OF TEXAS RIO GRANDE VALLEY

PHR: NARRATIVE The project aims to study the interaction between the N-terminus of snake PLA2 and human nAChR β2 subunit, deciphering the role of PLA2 in interacting with β2 subunit. The findings will contribute to understanding the signaling pathways of a particular human nAChR subtype relevant to health issues like overweight and obesity. Additionally, the project seeks to enrich the research skills of UTRGV undergraduate students and promote diversity in neuroscience research. 1

PI_NAMEs: JIA, YING  (contact)

PROGRAM_OFFICER_NAME: UMANAH, GEORGE KWABENA ESSIEN

PROJECT_TERMS: 3-Dimensional;Agonist;Alzheimer's Disease;Animals;antagonist;Bacterial Transformation;Binding;Biochemical;Biology;Biomedical Research;Calcium;career;Cell Physiology;Central Nervous System;Complex;design;Detection;Dideoxy Chain Termination DNA Sequencing;Discipline;Disease;DNA amplification;Educational Status;empowerment;Enzyme-Linked Immunosorbent Assay;Epilepsy;experimental study;extracellular;Functional disorder;Funding;Future;Generations;Goals;graduate student;Health;Human;Institution;Instruction;Lead;Learning;Ligands;Maps;Measures;Medical;Membrane Potentials;Molecular;Molecular Biology Techniques;National Institute of Neurological Disorders and Stroke;Natural Selections;Nervous System;Nervous System Disorder;Neurons;Neurosciences;Neurosciences Research;neurotoxicity;next generation;Nicotine Dependence;nicotinic receptor beta2;Nicotinic Receptors;Obesity;Organism;Outcome;Overweight;Paper;Paralysed;Parkinson Disease;Peer Review;pharmacologic;Phospholipase A2;Physiological;Physiological Processes;polypeptide;posters;programs;Property;Proteins;Publishing;receptor;Research;Research Activity;Research Personnel;Research Proposals;Role;role model;Science;Scientist;Signal Pathway;skills;Snake Venoms;Snakes;Structure;student participation;Students;Techniques;tool;Toxin;Training;undergraduate student;Underrepresented Populations;Venoms;Work

PROJECT_TITLE: Identifying the interactions between animal toxins and human nAChRs: the role of snake PLA2 in interacting with nAChR alpha subunits


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Precision Medicine

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

ORG_STATE: MA

PHR: NARRATIVE The proposed research is relevant to public health because it will lead to development of biomarkers that reflect granular neurobiological principles underlying ASD and related neurodevelopmental conditions. Among these individuals, understanding and addressing challenges related to atypical sensory processing is repeatedly noted as a common goal that would improve quality of life. In the long term, by developing objective brain-based measures of sensory processing (which has historically been a subjective phenomenon), this work has the potential to elevate research for a host of different diseases, alongside a wide variety of neurodevelopmental and sensory conditions.

PI_NAMEs: LEVIN, APRIL R. (contact)

PROGRAM_OFFICER_NAME: HARDY, KRISTINA KOREN

PROJECT_TERMS: 4 year old;Address;Anxiety;Attention;autism spectrum disorder;autistic children;behavior prediction;Behavioral;behavioral phenotyping;Biological Markers;biomarker development;biotypes;Brain;brain based;Caregivers;Child;Classification;clinical diagnostics;Complement;Data;Development;diagnostic development;Disease;Electroencephalography;endophenotype;Functional disorder;functional outcomes;Goals;improved;Individual;individuals with autism spectrum disorder;innovation;Measurement;Measures;Methods;neural circuit;Neurobiology;Neurodevelopmental Disorder;neuromechanism;Neurophysiology - biologic function;novel;outcome prediction;personalized medicine;Public Health;Quality of life;Research;response;Sensory;sensory input;Sensory Process;sensory stimulus;social skills;Stratification;Subgroup;Symptoms;Testing;time use;Work

PROJECT_TITLE: Paradoxical Sensory Responses: A Clue Towards Understanding Biotypes in Autism Spectrum Disorder and Other Neurodevelopmental Disorders (R01 Diversity Supplement - Rogers)