ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative: The proposed project has significant relevance to public health as it studies the role of a novel molecule with potential role in atherosclerosis. Atherosclerosis is the clogging of arteries which may lead to chest pain, heart attacks, heart failure or stroke, with atherosclerotic heart disease causing ≈1 of every 6 deaths in the United States according to the 2018 American Heart Association statistics. Findings from our proposed project will provide new insight into the mechanism of the disease, and could lead to therapies preventing or treating atherosclerosis.

PI_NAMEs: REZVAN, AMIR  (contact)

PROGRAM_OFFICER_NAME: CHEN, JUE

PROJECT_TERMS: Address;adenoviral mediated;Adhesions;Affect;American Heart Association;angiogenesis;Apolipoprotein E;Apoptosis;Apoptotic;Area;Arteries;athero susceptible;atheroprotective;Atherosclerosis;Binding;Binding Sites;Biological Assay;Cardiovascular Physiology;Cell Physiology;Cell Proliferation;Cessation of life;Chest Pain;ChIP-seq;comparison control;Coronary Arteriosclerosis;Coronary heart disease;Data;Dendritic Cells;differential expression;Disease;Endothelial Cell Inhibitor;Endothelial Cells;Endothelium;Experimental Models;Exposure to;Funding;Future;gain of function;Gene Expression;Gene Targeting;Genes;Heart failure;Hydrogen Peroxide;immune cell infiltrate;in vivo;Inflammation;Inhibition of Cell Proliferation;inhibitor;insight;Knockout Mice;Ligation;loss of function;Luciferases;Mediating;Methods;Modeling;monocyte;Morbidity - disease rate;mortality;mouse model;Mus;Myocardial Infarction;neovascularization;novel;overexpression;Peripheral arterial disease;Predisposition;prevent;Process;Proliferating;promoter;Proteins;Public Health;Regulation;Reporter;response;Role;senescence;Site;Small Interfering RNA;Smooth Muscle Myocytes;statistics;Stimulus;Stroke;Testing;therapeutic target;Time;TNF gene;transcription factor;tumor;United States;United States National Institutes of Health;WNT Signaling Pathway

PROJECT_TITLE: The role of shear induced endothelial ZBTB46 in atherosclerosis

STUDY_SECTION: AICS

STUDY_SECTION_NAME: Atherosclerosis and Inflammation of the Cardiovascular System Study Section[AICS]


ADMINISTERING_IC: AI

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;Infectious Diseases;Rare Diseases;Vector-Borne Diseases;Zika Virus

ORG_CITY: ALBANY

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOLOGY

ORG_FIPS: US

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT ALBANY

ORG_STATE: NY

PHR: Epitranscriptomic marks on viral RNAs are emerging as important regulators of viral gene expression. In this project we will combine next generation sequencing technologies together with molecular assays to identify the nucleotide position of pseudouridine on Zika virus RNA and determine the function of this epitranscriptomic mark during virus infection in human and mosquito host cells. This research will broaden our knowledge of viral epitranscriptomics and possibly identify novel targets for antiviral therapeutics targeting Zika virus.

PI_NAMEs: PAGER, CARA THERESIA (contact)

PROGRAM_OFFICER_NAME: GAUTAM, RAJEEV

PROJECT_TERMS: Affect;Affinity;Americas;Anti-viral Agents;Antisense Oligonucleotides;Appearance;Biological Assay;Biotinylation;Cell Line;Cell Nucleus;Cells;Chemicals;combinatorial;Culicidae;Cytoplasm;Defect;Detection;Development;Disease Outbreaks;Enzymes;epitranscriptomics;Flavivirus;Gene Expression;Genome;Goals;Health;Hepatitis C virus;hepatoma cell;HIV-1;Human;Immune response;improved;infancy;Infection;insight;Knowledge;Label;Length;Life Cycle Stages;Luciferases;Mass Spectrum Analysis;Methodology;Microcephaly;Modification;Molecular;Molecular Biology;mosquito-borne;Mutagenesis;Neurologic;new therapeutic target;next generation sequencing;novel;Nuclear Export;Nucleotides;overexpression;Plaque Assay;Polyribosomes;Positioning Attribute;Proteins;Pseudouridine;Regulation;Replicon;Reporting;Research;Reverse Transcription;RNA;RNA Folding;RNA Interference;RNA Stability;RNA Viruses;RNA-Protein Interaction;Role;Site;Site-Directed Mutagenesis;Stress;Structure;System;Techniques;Technology;Testing;Therapeutic;therapeutic target;Time;Transcript;transcriptome sequencing;Translations;Untranslated Regions;Viral;Viral Genes;Viral Physiology;Viral Proteins;viral RNA;viral transmission;Virion;Virus;Virus Assembly;Virus Diseases;Western Blotting;Woman;ZIKA;Zika Virus;ZIKV infection

PROJECT_TITLE: Functional Role of Pseudouridine on Zika Virus Gene Expression

STUDY_SECTION: MCV

STUDY_SECTION_NAME: Molecular and Cellular Biology of Virus Infection Study Section[MCV]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: Project Narrative Predicting the impact of disease variants on molecular and cellular function is essential to uncovering disease mechanisms and discovering therapeutics. In this proposal, we aim to understand genomic regulatory function by integrating ever-evolving functional genomics data. The tools that we will develop to predict the functional impact of disease risk variants, predict the genes impacted by disease variants, and defining the pathways impacted by disease variants, will enable mechanistic understanding of a broad spectrum of human diseases.

PI_NAMEs: PRICE, ALKES L;RAYCHAUDHURI, SOUMYA  (contact);SUNYAEV, SHAMIL

PROGRAM_OFFICER_NAME: GILCHRIST, DANIEL A

PROJECT_TERMS: Address;Affect;Alleles;Base Pairing;Benchmarking;Biological;Biological Assay;Biology;Catalogs;causal variant;Cell Physiology;cell type;Cells;ChIP-seq;Chromatin;Cleavage Under Targets and Release Using Nuclease;clinically actionable;Code;cohort;Collaborations;Complex;Computer software;Computing Methodologies;CRISPR screen;Data;data exchange;data integration;Data Set;de novo mutation;Development;differential expression;Disease;Disease Pathway;disorder risk;Drug Targeting;Epigenetic Process;flexibility;functional genomics;Gene Expression Regulation;Gene Frequency;Genes;Genetic;Genetic study;Genetic Transcription;genetic variant;Genetic Variation;genome sequencing;genome wide association study;genome-wide;Genomic approach;genomic data;Genomics;Genotype;Goals;Heritability;Heterogeneity;Hi-C;human disease;Human Genetics;improved;Individual;insight;interest;large scale data;Letters;Link;Localized Disease;Maps;Mendelian disorder;Methods;Modeling;Molecular;Mutation;Network-based;Nucleic Acid Regulatory Sequences;Parental Ages;Pathogenicity;Pathway interactions;Phenotype;Population Genetics;pressure;Price;programs;Publications;Rare Diseases;rare variant;Recording of previous events;Records;Regulatory Element;Research Personnel;Resolution;risk variant;Sampling;single cell ATAC-seq;single-cell RNA sequencing;Source;success;synergism;Testing;Therapeutic;therapeutic target;Time;tool;trait;transcription factor;transcriptomics;Untranslated RNA;Validation;Variant;whole genome

PROJECT_TITLE: Predicting the impact of genetic variants, genes and pathways on human Disease


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Autoimmune Disease;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE The proposal aims to study the role of microglia in neuromyelitis optica, with particular focus on astrocyte-microglia interaction in the evolving spinal cord lesion. We anticipate the results will advance understanding of neuroimmune interaction in neuromyelitis optica and potentially justify therapeutic targeting of microglia in future management of patients with neuromyelitis optica. New principles and therapeutic strategies discovered may be applicable to other IgG-mediated disorders affecting the central nervous system and neurodegenerative neurological diseases with an inflammatory, complement-mediated component.

PI_NAMEs: LENNON, VANDA A (contact);WU, LONG-JUN

PROGRAM_OFFICER_NAME: UTZ, URSULA

PROJECT_TERMS: Ablation;Address;Affect;Agonist;aquaporin 4;Astrocytes;Autoimmune Diseases;Autoimmunity;Automobile Driving;Behavioral;Binding;Blindness;Cells;Central Nervous System;Cessation of life;Communication;Complement;Complement 3a;conventional therapy;Coupled;Data;Demyelinations;Designer Drugs;designer receptors exclusively activated by designer drugs;Development;diphtheria toxin receptor;Disease;Event;Evolution;experience;experimental study;Functional disorder;Future;Genetic;genetic approach;genetic technology;glial activation;Gliosis;GTP-Binding Proteins;IgG autoantibodies;Image;Immune;Immunoglobulin G;Immunosuppression;Impairment;improved;Inflammation;Inflammatory;Infusion procedures;inhibitor;Knockout Mice;Lesion;Mediating;Membrane;Microglia;Minocycline;Modeling;Molecular;monocyte;Morbidity - disease rate;Motor;motor disorder;motor impairment;mouse model;Multiple Sclerosis;Mus;Nature;Nerve Degeneration;Nervous System Disorder;Neuroimmune;neuroinflammation;Neuromyelitis Optica;Neuronal Dysfunction;Neuronal Injury;novel;Optic Nerve;Outcome;Oxidative Stress;Paralysed;Pathogenesis;pathogenic autoantibodies;Pathologic;Patients;Pattern;pharmacologic;prevent;Prevention;Process;Production;Proteins;Protons;receptor;Relapse;Research;response;Role;Secondary to;selective expression;Spinal Cord;Spinal Cord Lesions;Testing;Therapeutic;therapeutic target;Time;tool;two-photon;voltage;water channel

PROJECT_TITLE: The role of microglia in neuromyelitis optica

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Chronic Pain;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy

ORG_CITY: BLACKSBURG

ORG_DEPT: NEUROSCIENCES

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

ORG_STATE: VA

PHR: Chemotherapy-induced peripheral neuropathy (CIPN) affects ~70% of cancer patients in the first month and may persist indefinitely. Pain hypersensitivity and affective disorders impair patient quality of life, underscoring the need for new treatments. This proposal evaluates the anti- nociceptive effects of cocaine and amphetamine-regulated transcript peptide II (CART II) as a potential non-opioid alterative approach for treating CIPN.

PI_NAMEs: BUCZYNSKI, MATTHEW WALLACE (contact)

PROGRAM_OFFICER_NAME: ALTSHULER, RACHEL DINA

PROJECT_TERMS: Absence of pain sensation;Acute;Acute Pain;Affect;Affinity;Aftercare;allodynia;Analgesics;antagonist;anti-depressive agents;Antineoplastic Agents;antinociception;Anxiety;Behavior;Behavior Control;Behavioral;Biological Assay;Brain;Cancer Patient;CARTPT gene;Cells;Chemicals;Chemotherapy-induced peripheral neuropathy;chronic pain;Clinical;Data;DNQX;Dose;drug candidate;duloxetine;Evaluation;Excitatory Amino Acid Antagonists;Exhibits;experimental study;extracellular;Face;Female;Genetic;Glutamates;Hyperalgesia;Hypersensitivity;Impairment;in vivo;inhibitor;Knockout Mice;Lysophosphatidic Acid Receptors;male;Mass Spectrum Analysis;Measures;Mediating;Mental Depression;Microdialysis;midbrain central gray substance;Molecular;Mood Disorders;Mus;neurochemistry;Neuropeptides;neurotransmission;Neurotransmitters;Nociception;non-opioid analgesic;Norepinephrine;novel;novel therapeutic intervention;novel therapeutics;Nucleus Accumbens;Opioid;Opioid Peptide;Output;Paclitaxel;Pain;Pain management;pain relief;painful neuropathy;Patients;Peptides;Pharmacologic Actions;Pharmacology;Pilot Projects;positive allosteric modulator;prevent;Quality of life;receptor;response;Risk;Role;Safety;Serotonin;sex;Sex Differences;Signal Pathway;Signal Transduction;Site;System;Tactile;Testing;Therapeutic;tool;treatment response;uptake;Work

PROJECT_TITLE: Anti-nociceptive actions of CART II in chemotherapy-induced peripheral neuropathy

STUDY_SECTION: NPI

STUDY_SECTION_NAME: Neurobiology of Pain and Itch Study Section [NPI]


ADMINISTERING_IC: EY

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Genetics;Macular Degeneration;Neurodegenerative;Neurosciences;Prevention;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_NAME: SCHEPENS EYE RESEARCH INSTITUTE

PHR: NARRATIVE Retinal pigment epithelium cells, a population of cells that lies underneath and supports the neural retina, degenerates with aging and are believed to be the primary site for the initiation of age-related macular degeneration. Age-related modifications of genes and epigenetic changes disrupt youthful DNA patterns, resulting in cellular dysfunction and senescence; yet, it has been shown recently that these age-related modifications can be reversed through a process called “partial epigenetic reprogramming”. This application proposes to test the hypothesis that partial epigenetic reprogramming can reverse retinal pigment epithelial cell aging in vivo, their injury profile in vitro, and inhibit the formation of AMD-like pathologies in a mouse model.

PI_NAMEs: HU, ZHENGPING  (contact)

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: Adult;age related;Age related macular degeneration;aged;Aging;aging related;Atrophic;axon regeneration;bevacizumab;Blindness;career;Cell Aging;Cell Death;cell injury;Cell Physiology;Cell Reprogramming;Cells;Cellular Morphology;Cellular Stress;Cholesterol;cigarette smoking;comparative;Complement;Complement Activation;Crush Injury;Data;Deposition;Development;Diet;DNA;DNA Methylation;Doxycycline;Dryness;Elderly;Electrophysiology (science);Electroretinography;Epigenetic age;epigenetic aging;Epigenetic Process;epigenome;epithelial injury;Exudative age-related macular degeneration;Eye diseases;Fatty acid glycerol esters;Functional disorder;Gene Delivery;Gene Modified;Glaucoma;Heterozygote;high risk;Human;improved;In Vitro;in vivo;in vivo Model;in vivo regeneration;induced pluripotent stem cell;Injury;insight;Investigation;juvenile animal;Knowledge;Mediating;Mentors;methylation pattern;Modeling;Modification;Molecular;Morphology;mouse model;Mus;neovascular;Neural Retina;Nitrogen;Nonexudative age-related macular degeneration;novel therapeutic intervention;old mice;Optic Nerve;Oxidative Stress;oxidized low density lipoprotein;Oxygen;Pathologic;Pathology;Pathway interactions;patient derived induced pluripotent stem cells;Pattern;Phase;Photoreceptors;Play;pluripotency;Population;prevent;Process;programs;Regenerative capacity;Reporting;Research Personnel;Resistance;response;Retina;Retinal Degeneration;Retinal Diseases;Retinal Ganglion Cells;Retinal Pigments;Risk;Risk Factors;Role;Safety;senescence;Serum;Signal Pathway;Site;skills;sodium iodate;stem cell differentiation;Structure of retinal pigment epithelium;Testing;Therapeutic;Tobacco;Tobacco smoking behavior;Training;transcriptome;Transmission Electron Microscopy;Vision;Work

PROJECT_TITLE: Partial epigenetic reprogramming of retinal pigment cells in age-related degeneration, dysfunction, and injury


ADMINISTERING_IC: GM

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Wound Healing and Care

ORG_CITY: COLLEGE PARK

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

ORG_STATE: MD

PHR: PROJECT NARRATIVE Ancestry contributes to differences in disease development and wound healing. This work will address critical gaps in our understanding of the relationship between ancestry and the cell responses in wound healing through biomaterial microenvironments. In the long term, this work will lead to biomaterial models of health disparities for the improved identification of wound healing risks and outcomes.

PI_NAMEs: MOORE, ERIKA MICHELLE (contact)

PROGRAM_OFFICER_NAME: CHAO, CHIEN-CHUNG

PROJECT_TERMS: Address;African;African ancestry;Biocompatible Materials;CD34 gene;Cell Communication;Cell model;Cell Physiology;Cells;Chronic;Cicatrix;Clinical;Clinical Research;Development;Disease;Environment;European;European ancestry;experience;Extracellular Matrix;Fibrosis;Gene Expression;Genetic;Goals;Growth;healing;health disparity;Immune;improved;Individual;Inflammation;inhibitor;Injury;insight;Keloid;Measures;Methodology;Modeling;monocyte;Outcome;Oxidative Stress;Peripheral Blood Mononuclear Cell;Persons;Phenotype;progenitor;programs;Proteomics;Research;response;Risk;Site;social culture;sociocultural determinant;stem cells;Tissues;transcriptome sequencing;Vision;Work;wound;wound environment;wound healing;wound response

PROJECT_TITLE: Biomaterial Models of Ancestral Contributions to Wound Healing

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Aging;Assistive Technology;Bioengineering;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Neurosciences;Physical Activity;Physical Rehabilitation;Rehabilitation;Stroke

ORG_CITY: Newark

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF DELAWARE

ORG_STATE: DE

PI_NAMEs: ARTEMIADIS, PANAGIOTIS  (contact)

PROGRAM_OFFICER_NAME: NURMINSKAYA, MARIA

PROJECT_TERMS: Acceleration;Affect;Back;Biomechanics;Body Weight;Community Participation;Contralateral;conventional therapy;Data;Data Set;design;electric impedance;Engineering;Equilibrium;exoskeleton;functional electrical stimulation;functional outcomes;Gait;Gait abnormality;gait rehabilitation;Goals;hemiparesis;Hip region structure;Human;Impairment;Individual;Intervention;Joints;kinematics;Kinetics;Knowledge;Left;Leg;Length;Limb structure;Long term disability;Measures;Mechanics;Mediation;Meta-Analysis;Metabolic;Methods;Modeling;Motivation;motor learning;Movement;Muscle;neuromuscular;novel;Outcome;Output;Paresis;Patients;Population;Positioning Attribute;post stroke;predicting response;Protocols documentation;Quality of life;Reflex action;rehabilitation research;rehabilitation strategy;Rehabilitation therapy;Research;Research Personnel;response;Robot;robot assistance;robot rehabilitation;robotic device;Robotics;Science;sensory feedback;Side;simulation;Solid;Speed;Stroke;stroke rehabilitation;stroke survivor;Surface;Testing;Therapeutic;tool;Torque;Training;treadmill;United States;Update;Variant;walker;Walking;walking speed

PROJECT_TITLE: SCH: Model-informed patient-specific rehabilitation using robotics and neuromuscular modeling

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-VH-N(50)R]


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Aging;Bioengineering;Biotechnology;Diabetes;Eye Disease and Disorders of Vision;Macular Degeneration;Neurodegenerative;Neurosciences

ORG_CITY: CINCINNATI

ORG_NAME: UNIVERSITY OF CINCINNATI

ORG_STATE: OH

PHR: PROJECT NARRATIVE The proposed research is aimed at developing dose-controllable co-delivery drug delivery systems that can benefit patients with diabetic macular edema and other posterior eye diseases involving pathologic inflammation and choroidal neovascularization by reducing the frequency of intravitreal injections and local side effects associated with the frequent injections and high bolus dose.

PI_NAMEs: PARK, YOONJEE  (contact)

PROGRAM_OFFICER_NAME: BROWN, PATRICK

PROJECT_TERMS: Absorbable Implants;Adrenal Cortex Hormones;Affect;Age;Anti-Inflammatory Agents;bevacizumab;biodegradable polymer;Blindness;Bolus Infusion;capsule;Cataract;Cells;Choroidal Neovascularization;Chronic;Chronic Care;Chronic Disease;Clinical Trials;clinically relevant;Combined Modality Therapy;Conjunctival Hemorrhage;Crystalline Lens;Data;design;Development;Dexamethasone;diabetic;Diabetic Retinopathy;differential expression;Disease;dosage;Dose;Drug Controls;Drug Delivery Systems;Drug Implants;drug release kinetics;Edema;efficacy evaluation;Endothelial Cells;Equipment;Extravasation;Eye;Eye diseases;Fibrosis;Frequencies;Future;Genes;Glaucoma;Glucocorticoids;Goals;high intraocular pressure;histological studies;Human;Implant;implant design;improved;In Vitro;in vivo;in vivo fluorescence imaging;Inflammation;Inflammatory;Injections;intravitreal injection;irradiation;Kinetics;Lasers;Light;Liposomes;Macular degeneration;macular edema;Methods;Modeling;Monoclonal Antibodies;Nanoporous;novel;novel therapeutics;Oryctolagus cuniculus;Outcome;Pathologic;Patients;Permeability;Pharmaceutical Preparations;Physiologic Intraocular Pressure;Posterior Uveitis;Probability;Process;ranibizumab;Research;Research Personnel;Retina;retina blood vessel structure;Retinal Vein Occlusion;Risk;Running;side effect;standard of care;Structure;System;Technology;Testing;Time;Tissues;Trabecular meshwork structure;transcriptome sequencing;Translational Research;translational scientist;Treatment Efficacy;Vascular Endothelial Growth Factors;VEGF165

PROJECT_TITLE: Co-Delivery Dose-Controllable Implants for Advanced Chronic Eye Disease Treatment


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease;Neurosciences;Pediatric;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: SCOTTSDALE

ORG_NAME: MAYO CLINIC ARIZONA

ORG_STATE: AZ

PHR: Project narrative Myocardial infarction occurs in many types of congenital heart diseases and surgical treatments. Recent case reports indicate that newborn patients may be able to regenerate myocardium and recover from severe myocardial infarction that occurred shortly after birth. In this project, we will exploit the high regenerative capacity of neonatal pig heart model to decipher the mechanisms of heart regeneration in large mammals.

PI_NAMEs: ZHU, WUQIANG  (contact)

PROGRAM_OFFICER_NAME: TJURMINA, OLGA A

PROJECT_TERMS: Address;Adhesives;Adult;angiogenesis;Angiogenic Factor;Antibodies;bevacizumab;Biocompatible Materials;Birth;Blood flow;Blood Vessels;Cardiac;Cardiac Myocytes;cardiac regeneration;Cardiac Surgery procedures;cardiogenesis;Case Study;Cell Cycle;Cell Survival;Cells;Chemicals;Clinical Research;Coculture Techniques;congenital heart abnormality;cytokine;Data;Embryo;Endothelial Cells;Endothelium;enhancing factor;experimental study;Family suidae;FDA approved;fetal;Fishes;Functional disorder;Future;Ganglionectomy;Generations;Growth;Heart;Heart Injuries;heart innervation;Human;human induced pluripotent stem cells;Hydrogels;induced pluripotent stem cell derived cardiomyocytes;Injury;Intervention;ischemic injury;Link;Maintenance;Mammals;Maps;Mediating;Modeling;mouse model;Mus;Myocardial;Myocardial Infarction;Myocardial Ischemia;Myocardium;nanoparticle delivery;Natural regeneration;Neonatal;neonatal mice;Nerve Growth Factors;nerve supply;neural;neural network;Neuregulin 1;Neurons;neurotrophic factor;Newborn Infant;novel;Nutrient;Operative Surgical Procedures;paracrine;Patients;Peripheral;pharmacologic;postnatal;Proliferating;Proteomics;Publications;Radionuclide Imaging;Recombinants;regeneration potential;Regenerative capacity;Regenerative response;Reporting;Research;response;revascularization;Rodent;Role;Signal Pathway;single-cell RNA sequencing;Smooth Muscle Myocytes;Stress;Testing;Therapeutic;Therapeutic Intervention;ultrasound;Vagotomy;Vascular Endothelial Cell;Vascular Endothelial Growth Factors;Vascularization;Ventricular;Vertebrates;Zebrafish

PROJECT_TITLE: Cardiomyocyte Non-autonomous Factors and Cardiac Regeneration in Large Mammals


ED_INST_TYPE: SCHOOLS OF MEDICINE

NIH_SPENDING_CATS: Antimicrobial Resistance;Clinical Research;Genetics;Infectious Diseases;Malaria;Prevention;Rare Diseases;Vector-Borne Diseases

ORG_CITY: CHAPEL HILL

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE Emergence of Plasmodium falciparum strains with resistance to first-line artemisinin-combination therapies threatens malaria control and elimination efforts across the Horn of Africa. Improved understanding of the epidemiology and determinants of drug-resistant falciparum malaria, including infections by drug- and diagnostic-resistant strains with hrp2/3 deletions, is needed to inform clinical management and policy decisions in the region. We will conduct population surveys across Ethiopia and characterize resistant parasites, integrating our findings into a point-of-care clinical tool for identifying individuals with drug-resistant falciparum malaria and into a model to predict the future spread of resistance mutations.

PI_NAMEs: PARR, JONATHAN BOYD (contact)

PROGRAM_OFFICER_NAME: RAO, MALLA R

PROJECT_TERMS: accurate diagnosis;Address;Affect;Africa;alternative treatment;Anti-malarial drug resistance;Anti-malarials;arm;Artemisinins;Behavioral;Cessation of life;Clinic;Clinical;clinical care;Clinical Management;clinical practice;clinical predictors;clinical risk;Collaborations;Collection;Combined Modality Therapy;Communities;Complex;cost;Country;Culicidae;Data;Deletion Mutation;design;Detection;Development;Diagnosis;Diagnostic;diagnostic strategy;Diagnostic tests;Drug resistance;effective therapy;Environment;Epidemiology;Ethiopia;Ethiopian;experimental study;Falciparum Malaria;fitness;Future;Gene Deletion;Genes;Genetic;Genetic Polymorphism;Health;Health care facility;Horns;HRP-2 protein;Human;human model;improved;In Vitro;in vivo;Incidence;Individual;Infection;Investments;Malaria;Mediating;migration;Modeling;Monitor;Movement;multiple data sources;Mutation;Parasite resistance;Parasites;Persons;Pharmaceutical Preparations;Plasmodium falciparum;point of care;Policies;Population;population survey;Positioning Attribute;predictive modeling;predictive tools;pressure;Prevalence;prevent;programs;prospective;Public Health;rapid diagnosis;Rapid diagnostics;Regimen;Reporting;Residencies;Resistance;resistance mutation;Resistance to infection;resistant Plasmodium falciparum;resistant strain;Risk;Risk Factors;risk prediction model;Selection for Treatments;Statistical Models;Surveys;Testing;therapy design;Time;tool;transmission process;Travel;treatment strategy;Uncertainty;Vertebral column

PROJECT_TITLE: Epidemiology and determinants of emerging artemisinin-resistant malaria in Ethiopia

STUDY_SECTION: PRID

STUDY_SECTION_NAME: Population based Research in Infectious Disease Study Section[PRID]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Influenza;Lung;Pneumonia and Influenza

PHR: Project narrative: Protective immunity against viruses depends on memory cytotoxic CD8+ T cells – therefore, understanding how memory CD8+ T cell survive long-term will positively impact antiviral therapies and immunizations. We recently identified that sensing of the “danger signal” extracellular ATP (via its receptor P2RX7) induces antiviral memory CD8+ T cells, but it is still unclear (a) if P2RX7 imprints memory CD8+ T cell longevity in a subset of memory precursors or in all cells seeding the memory pool, and (b) how this receptor promotes long-lived memory in response to tissue-localized infections, especially the medically relevant influenza virus. These questions will be addressed in this proposal.

PI_NAMEs: BORGES DA SILVA, HENRIQUE  (contact)

PROGRAM_OFFICER_NAME: MALLIA, CONRAD M

PROJECT_TERMS: adaptive immunity;Address;Affect;Anti-viral Therapy;Antibodies;antiviral immunity;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Death;Cell Survival;Cells;Circulation;Complement;Complex;CRISPR/Cas technology;Cues;cytotoxic CD8 T cells;Data;design;Development;Disease;Effector Cell;experimental study;extracellular;flu;Focal Infection;Future;Generations;Genetic;Goals;Homeostasis;Immune response;Immunity;Immunization;imprint;Infection;Inflammation;Inflammatory;Influenza;influenza infection;influenza virus strain;influenzavirus;interest;Knock-out;Knowledge;Longevity;Lung;lung injury;Maps;Mediating;Medical;Memory;Natural Immunity;overexpression;Pathway interactions;Persons;Population;receptor;Regulation;Reporter;Reporting;response;Role;Route;secondary lymphoid organ;sensor;Signal Transduction;Structure of parenchyma of lung;Systemic infection;Testing;Time;Tissues;tool;United States;Up-Regulation;Vaccines;Viral;Virus;Virus Diseases

PROJECT_TITLE: Control of antiviral memory CD8+ T cell longevity by extracellular ATP sensing

STUDY_SECTION: IHD

STUDY_SECTION_NAME: Immunity and Host Defense Study Section[IHD]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Caregiving Research;Clinical Research;Comparative Effectiveness Research;Cost Effectiveness Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: RICHMOND

ORG_DEPT: ADMINISTRATION

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

PHR: Project Narrative This project will use a combination of Markov models, stated preference data and econometric models of treatment take-up to calculate the costs, benefits, societal value and health equity impacts of novel treatments or Alzheimer disease and Alzheimer's disease-related dementias.

PI_NAMEs: ATHERLY, ADAM J (contact)

PROGRAM_OFFICER_NAME: CHATTERJI, MINKI

PROJECT_TERMS: Acceleration;Aducanumab;Adverse effects;African American;Age of Onset;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Alzheimer's disease therapeutic;Amyloid;Amyloid beta-Protein;Black American;Black Populations;Calibration;care giving burden;Caregiver Burden;Caregivers;Caring;caucasian American;clinical efficacy;clinical trial enrollment;Clinical Trials;community based participatory research;community engagement;community partners;Continuity of Patient Care;cost;cost effectiveness;Cost Effectiveness Analysis;cost estimate;Costs and Benefits;Data;data modeling;Diagnosis;discrete data;Disparity;Early treatment;Econometric Models;economic value;Economics;Elements;Equation;ethnic difference;ethnic minority;ethnoracial;ethnoracial minority;experimental study;Family;family burden;Family member;Financial Hardship;Flowers;Focus Groups;Grant;health equity;healthy aging;Heterogeneity;Hispanic Americans;improved;Inequality;Life Expectancy;Literature;Logit Models;markov model;Measures;Medicare;Methodology;Methods;Minority Groups;Modeling;models and simulation;Monoclonal Antibodies;Motivation;novel;novel therapeutics;Outcome;Patients;Pharmaceutical Preparations;Pharmacological Treatment;Phase;Policies;Population;preference;Prevalence;Probability;Quality-Adjusted Life Years;Race;racial difference;racial minority;racial population;Reduce health disparities;Research;Research Methodology;Resources;Risk;Severity of illness;Structure;Therapeutic;treatment and outcome;treatment disparity;trend;underserved area;United States;United States Centers for Medicare and Medicaid Services;United States Food and Drug Administration;Update;uptake

PROJECT_TITLE: Measuring the Impact of the Value Flower and Unobserved Heterogeneity on the Cost Effectiveness and Use of Novel Treatments for Alzheimer's Disease and Related Dementias


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF OSTEOPATHIC MEDICINE

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Harm Reduction for Substance Misuse;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Opioid Misuse and Addiction;Opioids;Prevention;Primary Health Care;Rural Health;Social Determinants of Health;Substance Misuse

ORG_CITY: ATHENS

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: OHIO UNIVERSITY ATHENS

PHR: Project Narrative: Buprenorphine is an evidence-based treatment for opioid use disorder that also has strong potential to reduce HIV transmission in people who use drugs. Rural health care professionals are eligible and critically needed to provide these medications, but stigma currently limits provider willingness to prescribe buprenorphine, especially in regions where mortality and HIV transmission secondary to opioid use are high. In this developmental trial, we will adapt, refine, and test the feasibility of a prototype brief stigma-reduction training intervention aimed at increasing buprenorphine prescribing in the rural primary care setting.

PI_NAMEs: FRANZ, BERKELEY  (contact)

PROGRAM_OFFICER_NAME: LYNCH, SEAN EDWARD WINTERS

PROJECT_TERMS: acceptability and feasibility;Address;Adoption;Affect;Appalachian Region;Area;Attitude;Awareness;Behavior;Buprenorphine;burnout;Caring;Clinic;cohort;Communities;Control Groups;County;Data;Development;Disease Outbreaks;disease transmission;Drug Prescriptions;Drug usage;Drug user;Educational Intervention;Eligibility Determination;Empathy;Evidence based treatment;experience;Exposure to;Family;feasibility testing;Feedback;Feeling;Focus Groups;follow-up;Future;Goals;Harm Reduction;Health Professional;HIV;HIV risk;injection drug use;Intervention;intervention refinement;Interview;Knowledge;Label;Measures;medication for opioid use disorder;Methods;mortality;naloxone dispensing;Nature;Needle-Exchange Programs;negative emotional state;Nurse Practitioners;Ohio;Opiate Addiction;Opioid;opioid epidemic;opioid misuse;opioid use;opioid use disorder;Outcome;Patient Self-Report;Patients;peer;Perception;Persons;perspective taking;Pharmaceutical Preparations;Physician Assistants;Physicians;Pilot Projects;pilot trial;Play;practice setting;prevent;Primary Care;primary care clinic;primary care practice;primary care provider;primary care setting;Primary Health Care;prototype;Provider;psychologic;Randomized;Randomized, Controlled Trials;Reporting;Role;Rural;rural area;rural counties;rural healthcare;Rural Population;Sampling;secondary outcome;Secondary to;social health determinants;social stigma;Stigmatization;Stress;Structure;substance use treatment;Surveys;Testing;therapy development;tool;Training;transmission process;underserved community;United States;waiver;willingness;Work

PROJECT_TITLE: Developing a Tailored Stigma Reduction Intervention to Increase Buprenorphine Prescribing among Rural Primary Care Providers in Ohio

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


ED_INST_TYPE: HOSPITALS

ORG_CITY: HOUSTON

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: Project narrative Despite promising new therapeutics, lung cancer remains a devastating disease and is the top cause of cancer mortality. We recently showed that a particular cellular metabolic process called oxidative phosphorylation is essential for growth of a subtype of lung cancer and discovered a potent chemical inhibitor of this process. In this proposal, we aim to perform in depth biological studies to better understand the mechanism of the metabolic rewiring in this lung cancer subtype and explore the therapeutic potential of inhibition of oxidative phosphorylation in such tumors.

PI_NAMEs: LISSANU, YONATHAN  (contact)

PROGRAM_OFFICER_NAME: VENKATACHALAM, SUNDARESAN

PROJECT_TERMS: Ablation;ARID1A gene;Biogenesis;Biological;Biological Models;cancer cell;Cancer cell line;Cancer Etiology;cancer subtypes;Catalytic Domain;Cells;Cellular Metabolic Process;Chemicals;Chromatin;Chromatin Remodeling Factor;Clinic;Clinical;clinical development;Clinical Research;clinically relevant;Complex;CRISPR/Cas technology;Custom;Data;Dependence;design;Development;Disease;Drug Combinations;Drug Targeting;efficacy testing;Epidermal Growth Factor Receptor;FDA approved;Foundations;Frequencies;Future;Gene Expression;gene product;Gene Targeting;Genes;Genetic Screening;Genetic Transcription;Genetically Engineered Mouse;Genomics;Goals;Growth;Guide RNA;Immunotherapy;improved;in vivo;inhibitor;insight;Knock-out;Libraries;LoxP-flanked allele;lung cancer cell;Lung Neoplasms;Maintenance;Malignant neoplasm of lung;Malignant Neoplasms;Mediating;Metabolic;Metabolism;metabolomics;Mitochondria;Modeling;mortality;mouse model;Mus;mutant;Mutate;Mutation;Non-Small-Cell Lung Carcinoma;novel;novel therapeutics;Oxidative Phosphorylation;Oxygen;Oxygen Consumption;patient derived xenograft model;Patients;Pharmaceutical Preparations;Phosphorylation Inhibition;Positioning Attribute;pre-clinical;Process;programmed cell death ligand 1;Publishing;response;Role;Screening Result;small molecule;SMARCA4 gene;Stress;Sucrose;synergism;targeted treatment;Therapeutic;Therapeutic Studies;therapeutically effective;tool;TP53 gene;Translating;treatment strategy;tumor;tumor growth;tumor microenvironment;Tumor Suppressor Proteins;tumor xenograft;Work;Xenograft procedure

PROJECT_TITLE: Mechanisms and Vulnerabilities of  SWI/SNF chromatin remodeling complex mutant lung cancer

STUDY_SECTION: DT

STUDY_SECTION_NAME: Developmental Therapeutics Study Section[DT]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Eye Disease and Disorders of Vision;Neurosciences

ORG_NAME: METHODIST HOSPITAL RESEARCH INSTITUTE

PHR: PROJECT NARRATIVE Although the phenomenon of subliminal priming has been known for decades, whether and how sensory information is encoded in the brain in the absence of awareness remains a mystery. We will perform multiple- electrode recording simultaneously in two visual cortical areas of non-human primate to examine the neural dynamics and coding of subliminal stimuli across neuronal circuits, and their impact on perceptual performance. Our research has the potential to advance our understanding of the neural underpinnings of vision while providing effective non-invasive therapies to treat the brain-based aspects of low vision conditions which can lead to life- altering benefits for many millions of people worldwide.

PI_NAMEs: DRAGOI, VALENTIN  (contact)

PROGRAM_OFFICER_NAME: FLANDERS, MARTHA C

PROJECT_TERMS: Age related macular degeneration;Amblyopia;Animals;Area;area V1;area V4;Attention;Awareness;Behavior;Behavioral;Brain;brain based;calmodulin-dependent protein kinase II;Cells;Code;Complex;Conscious;Diabetic Retinopathy;Discrimination;discrimination task;effective therapy;Electrodes;Exhibits;experience;experimental study;Exposure to;Goals;Human;Image;improved;Individual;Learning;Life;Link;Macaca;Masks;millisecond;neural;neuronal circuitry;Neurons;nonhuman primate;novel;optogenetics;Perception;Performance;Persons;Population;promoter;Property;receptive field;Research;Resolution;response;Sensory;sensory cortex;spatiotemporal;Stimulus;stimulus processing;Stroke;Subliminal Stimulation;Techniques;Testing;Time;transmission process;Unconscious State;V1 neuron;V4 neuron;Vision;Visual Cortex;Visual impairment;visual information;Visual Perception;visual stimulus

PROJECT_TITLE: Cortical encoding of unconscious visual information and its impact on behavior


ADMINISTERING_IC: NR

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Caregiving Research;Chronic Pain;Clinical Research;Opioid Misuse and Addiction;Opioids;Pain Research;Palliative Care;Patient Safety;Prevention;Substance Misuse

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project Narrative By investigating opioid-related benefits and risk factors for harms in individuals with metastatic cancer, the proposed study will provide evidence that patients, family caregivers, and clinicians need when engaged in opioid-related decision-making. This has the potential to transform pain and opioid care for patients with metastatic cancer, and as such, is directly responsive to National Institute of Nursing Research priorities to improve the health of individuals with serious illness and the National Cancer Institute’s mission of helping people with cancer lead longer, healthier lives.

PI_NAMEs: MERLIN, JESSICA S (contact);RITCHIE, CHRISTINE S

PROGRAM_OFFICER_NAME: MCNAMARA, KAREN MARIE

PROJECT_TERMS: Accounting;addiction;Age;Area;Behavioral;Belief;Benefits and Risks;Benzodiazepines;Body part;Characteristics;chronic pain patient;Collaborations;Data;Data Collection;Decision Making;Decision Modeling;decision research;Diagnosis;Discipline of Nursing;Disease;Disseminated Malignant Neoplasm;Distant;Dose;Drowsiness;Drug Prescriptions;Effectiveness;Effectiveness of Interventions;Event;evidence base;Exclusion;experience;Explosion;Family Caregiver;follow-up;Funding;Geography;Goals;Guidelines;Health;improved;Individual;insight;Intervention;Intervention Studies;Interview;Lead;Life;Literature;Malignant Neoplasms;Measures;Medical Records;Mental Health;Methodology;Mission;Modeling;Mood Disorders;morphine equivalent;National Cancer Institute;National Institute of Nursing Research;Newly Diagnosed;non-cancer chronic pain;novel;Oncology;Opioid;opioid misuse;opioid sparing;opioid therapy;opioid use;opioid use disorder;Outcome Assessment;Outcome Measure;Overdose;Pain;Pain interference;Pain management;palliate;Palliative Care;Patient Care;Patient Outcomes Assessments;patient prognosis;patient subsets;Patients;Persons;Pharmaceutical Preparations;Placebo Control;Population;prescription opioid;primary outcome;programs;Prospective cohort;Recommendation;Recording of previous events;Research;Research Priority;Risk;Risk Factors;Sedation procedure;Series;Severities;side effect;Site;stakeholder perspectives;standard of care;Substance Use Disorder;Testing;Time;Work

PROJECT_TITLE: Opioid therapy for pain in individuals with metastatic cancer: benefits, harms and stakeholder perspectives

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-Z(02)]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Depression;Heart Disease;Heart Disease - Coronary Heart Disease;Major Depressive Disorder;Mental Health;Mental Illness;Prevention;Serious Mental Illness;Sleep Research

ORG_CITY: SAINT LOUIS

ORG_DEPT: PSYCHIATRY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative Depression doubles the risk of death in patients with coronary heart disease (CHD), but so far, there is insufficient evidence that we can reduce the risk of death by treating depression. This study will investigate the cardiac risk markers that are associated with depression symptoms that remain despite treatment, and identify potential targets for their treatment. The results of the study will inform the development of more effective interventions to improve both depression and survival in patients with CHD.

PI_NAMEs: FREEDLAND, KENNETH E (contact)

PROGRAM_OFFICER_NAME: TATAW-AYUKETAH, GLADYS OROCK

PROJECT_TERMS: actigraphy;Aftercare;aggressive therapy;Anhedonia;anti-depressive agents;Behavioral Medicine;Biological Markers;Blood;C-reactive protein;Cardiac;Cardiology;Cardiovascular system;Chronic;circadian;Clinical;Clinical Trials;cofactor;Cognitive Therapy;common symptom;Compensation;Coronary heart disease;Depressed mood;depressed patient;depressive symptoms;Development;Disease remission;Disease Resistance;Disease-Free Survival;DSM-V;effective intervention;effective therapy;efficacy testing;Electrocardiogram;Eligibility Determination;Enrollment;Equipment;Equipment and supply inventories;Evaluation;Event;Exclusion Criteria;Fatigue;Future;Goals;Heart Diseases;Heart Rate;heart rate variability;high risk;Home;Hour;Hydrocortisone;Hyperthyroidism;improved;Instruction;Intervention;Interview;Lipids;Major Depressive Disorder;Measurement;Measures;Mediating;Medical;medical schools;Mental Depression;Modeling;Monitor;Morbidity - disease rate;mortality;mortality risk;Participant;Patient Self-Report;Patients;perceived stress;Physical activity;Plasma;poor sleep;Prognostic Marker;programs;randomized, clinical trials;Randomized, Controlled Trials;recruit;Research;Residual state;response;Risk;Risk Marker;Risk Reduction;saliva sample;Sampling;Schedule;sex;Sleep;Sleep Apnea Syndromes;Sleep Disorders;Sleep Fragmentations;sleep quality;standard care;Stressful Event;Structure;Sympathetic Nervous System;symptom treatment;Symptoms;Thyroid Diseases;Thyroid Gland;Thyroid Hormones;Thyroxine;Time;Treatment outcome;treatment response;Universities;Washington;Wrist

PROJECT_TITLE: Fatigue, Anhedonia and Cardiac Prognostic Markers in Depressed Patients with Coronary Heart Disease

STUDY_SECTION: BMIO

STUDY_SECTION_NAME: Behavioral Medicine, Interventions and Outcomes Study Section[BMIO]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: Encinitas

ORG_NAME: PERCEPTION DYNAMICS INSTITUTE

ORG_STATE: CA

PHR: This study will contribute to the fundamental knowledge of how to remediate visual and cognitive deficits resulting from a mTBI to enhance the health, lengthen the life and reduce the disabilities that result from a mTBI. The goal of this study is to determine the feasibility of a timing intervention (PATH neurotraining) to significantly improve working memory, processing speed (primary outcomes) and auditory working memory, selective attention, cognitive flexibility, sustained attention, reading speed, and reading proficiency (secondary outcomes) in mTBI patients more than after either Sham or conventional working memory training The present work is a critical step towards establishing feasibility of PATH training and determining early stage data demonstrating efficacy and understanding individual differences regarding which participants with mTBI may be the best targets for these types of timing interventions.

PI_NAMEs: LAWTON, TERI A (contact)

PROGRAM_OFFICER_NAME: AUBRECHT, TARYN GRACE

PROJECT_TERMS: Acceleration;Address;Age;age group;Area;Athletic Injuries;Attention;attentional control;Auditory;automobile accident;Back;Behavioral;Biological Markers;Brain;Brain Concussion;Clinical Trials;Cognition Disorders;Cognitive;cognitive ability;Cognitive deficits;cognitive function;Cognitive remediation;cognitive skill;cognitive testing;commercialization;Coupled;Data;Deceleration;design;Diagnosis;disability;Discrimination;Dorsal;dorsal visual stream;dosage;Educational Intervention;effective therapy;Event;executive function;Exhibits;falls;flexibility;functional improvement;Goals;Head;Health;Impaired cognition;Impairment;improved;Individual;Individual Differences;Intervention;Knowledge;Lateral;Life;Magnetoencephalography;Marketing;Memory;mild traumatic brain injury;Motion;Movement;Nature;neural correlate;Neural Pathways;Neurons;Neuropsychological Tests;neurotransmission;novel;Outcome;Participant;Pathway interactions;Patients;Performance;personalized medicine;Phase;phase 2 designs;phase II trial;Pilot Projects;Population;Post-Concussion Syndrome;Prefrontal Cortex;primary outcome;Process;processing speed;Quality of life;Questionnaires;Reaction Time;Reading;reading ability;Rehabilitation therapy;remediation;Research;research clinical testing;response;Rest;Running;Sampling;satisfaction;Schools;screening;secondary outcome;selective attention;Short-Term Memory;Speed;Standardization;sustained attention;TBI Patients;Testing;therapeutic evaluation;Training;treatment group;trial comparing;Unconscious State;vehicular accident;ventral visual stream;Veterans;Visual;Visual Cortex;Visual Motion;Work

PROJECT_TITLE: Retraining Neural Pathways to Improve Cognitive Skills after a Mild Traumatic Brain Injury (mTBI)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-NV-G(13)B]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Endocrine Disruptors;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Rehabilitation;Social Determinants of Health;Women's Health Research

ORG_CITY: ORANGE

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: CHAPMAN UNIVERSITY

PHR: PROJECT NARRATIVE The purpose of this career award is to support my training and career development trajectory toward becoming an independent, community-based implementation scientist and develop an intervention to reduce harmful, car- cinogenic chemical exposures as well as improve quality of life among Black breast cancer survivors.

PI_NAMEs: TETEH-BROOKS, DEDE K (contact)

PROGRAM_OFFICER_NAME: JOHNSON, JARRETT AINSWORTH

PROJECT_TERMS: Address;Advocacy;Affect;Aftercare;Award;Beauty;Behavior;Behavior Therapy;Biological;Black race;black women;Breast Cancer cell line;breast cancer survival;Breast Cancer survivor;Breast Cancer survivorship;California;cancer health disparity;cancer risk;Cancer Survivorship;carcinogenicity;career;career development;Caring;Cell Proliferation;Chemical Exposure;Chemicals;Cities;Clinic;Clinical;Communities;community based participatory research;community based research;community engagement;community intervention;community organizations;community partners;community setting;Comprehensive Cancer Center;Development;Diagnosis;Disparity;Dissemination and Implementation;dissemination science;Doctor of Philosophy;Educational Curriculum;Endocrine Disruptors;Endocrine system;Environmental Exposure;estrogenic;Ethnic Population;experience;Experimental Animal Model;Exposure to;Face;Frequencies;Goals;Hair;Hair Dyes;hazard;Health;Health behavior;health care availability;health disparity;Health Hazards;Human;Immune system;implementation science;improved;In Vitro;Income;Inequality;informant;Infrastructure;Intervention;intervention delivery;Interview;Invaded;Knowledge;Malignant Breast Neoplasm;Malignant Neoplasms;Mentors;Mentorship;migration;Outcome;Parabens;peer;personal care products;Population Intervention;post intervention;pressure;Procedures;professor;prototype;psychologic;psychosocial;Quality of life;racial population;Randomized;randomized trial;Recurrence;Reduce health disparities;Reproduction;Research;Research Personnel;Risk;Risk Reduction;Robin bird;Sampling;Scientist;social;social health determinants;social influence;Structural Racism;Surveys;Survival Rate;Survivors;survivorship;tenure track;therapy design;Training;trial design;Universities;Urine;Virginia;White Women;Women's Health

PROJECT_TITLE: Social and Environmental Determinants of Breast Cancer Survivorship: The Black Breast Cancer Survivors Intervention


PHR: The proposed research is relevant to public health because it focuses on optimizing outcomes for patients with severe aortic stenosis undergoing transcatheter aortic valve replacement (TAVR). Results from this study have the potential to change antithrombotic therapy guidelines for patients with valvular heart disease. The proposed work is relevant to the NHLBI's strategic goals to not only more effectively treat aortic stenosis but also, by advancing understanding of the thromboinflammatory response, improve thromboembolic and bleeding outcomes.

PI_NAMEs: LYNCH, DONALD RAY (contact)

PROGRAM_OFFICER_NAME: LIDMAN, KARIN FREDRIKSSON

PROJECT_TERMS: Acute;adverse outcome;Affect;aortic valve;aortic valve replacement;Aortic Valve Stenosis;Blood flow;Blood Platelets;calcification;Characteristics;Clinical;Clinical Research;Coagulation Process;cost;Data;Development;efficacious treatment;Event;FDA approved;Foundations;Functional disorder;Generations;Goals;Guidelines;Healthcare Systems;Heart;Heart Valve Diseases;Heart Valves;Hemorrhage;Hemostatic Agents;Hospitalization;Hour;improved;Inflammation;Inflammation Mediators;Inflammatory;Inflammatory Response;innovation;insight;Knowledge;Mass Spectrum Analysis;Measures;Mediating;monocyte;mortality;National Heart, Lung, and Blood Institute;Observational Study;Operative Surgical Procedures;Outcome;Pathologic;Pathway interactions;patient subsets;Patient-Focused Outcomes;Patients;Platelet aggregation;Procedures;prospective;Protein Disulfide Isomerase;Public Health;Research;response;Risk;Risk Factors;risk mitigation;Role;Sampling;secondary analysis;surgical risk;Surrogate Markers;System;Technology;Testing;Thrombin Receptor;Thrombocytopenia;thromboinflammation;Thromboplastin;thrombotic;Time;treatment choice;Work

PROJECT_TITLE: Platelets and Hemostatic Factors as Facilitators of the Inflammatory Response Following Transcatheter Aortic Valve Replacement

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(JA)]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: ITHACA

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: CORNELL UNIVERSITY

PHR: NARRATIVE Viruses that are able to establish persistent or chronic infections have developed strategies to suppress immune mechanisms that would normally eradicate the virus. Regulating inflammation in the face of persistent infection is also critical as many of the long-term problems of chronic infection are due to persistent inflammation, including increased risk of developing cancer. Our new data have uncovered an unexpected role for IL-17 in helping to limit T cell activation and inflammation as persistent infection becomes established, and here we propose to explore the sources and functions of IL-17 in immunoregulation of antiviral response.

PI_NAMEs: MCGEACHY, MANDY J (contact)

PROGRAM_OFFICER_NAME: JOFFE, AARON MICHAEL

PROJECT_TERMS: Adoptive Transfer;Anti-viral Response;Antibodies;antiviral immunity;Attention;Automobile Driving;Bacteria;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Count;Cell Physiology;Cell Proliferation;Cell Survival;Cells;cellular targeting;Chronic;chronic autoimmune disease;chronic infection;Chronic Phase;Clinical;Data;design;Development;Elements;exhaustion;extracellular;fungus;Future;Gene Expression Profiling;Genes;Genetic;Hepatitis B;HIV;IL17 gene;Immune;Immune response;Immunity;immunopathology;immunoregulation;Immunosuppression;improved;Infection;Inflammation;Inflammatory Response;Interferon Type II;Invaded;Kinetics;Lead;Lymphocytic choriomeningitis virus;Lymphoid;Lymphoid Tissue;Malignant Neoplasms;Mediating;Metabolic;Metabolic Pathway;microbiota;Modeling;Molecular Profiling;Morbidity - disease rate;Mus;novel;Outcome;pathogen;Pathology;Pathway interactions;Persons;Population;Production;Proliferating;Regulation;Regulatory T-Lymphocyte;response;Reticular Cell;Risk;Role;Signal Transduction;Source;Stromal Cells;Surface;T-Cell Activation;T-Lymphocyte;Testing;Therapeutic;Therapeutic Intervention;Time;tissue repair;Viral;Virus;Virus Diseases

PROJECT_TITLE: IL-17 regulation of type-1 immunity in chronic viral infection


NIH_SPENDING_CATS: Cardiovascular;Congenital Heart Disease;Congenital Structural Anomalies;Heart Disease;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Rare Diseases

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Relevance The ductus arteriosus (DA) is a fetal blood vessel whose patency is critical for survival in the womb, and whose closure is essential for adaption to newborn life. Persistent patency of the DA after birth (PDA) occurs frequently in preterm infants, increasing their risks for chronic lung disease and other complications. Because preterm infants are exposed to multiple drug combinations, this proposal will determine whether drugs used in the NICU may inadvertently impair DA closure and contribute to high rates of PDA.

PI_NAMEs: REESE, JOHN JEFFREY (contact)

PROGRAM_OFFICER_NAME: BURNS, KRISTIN

PROJECT_TERMS: Adverse effects;Affect;Aminoglycosides;Anemia;Animals;Antacids;Antibiotics;Aorta;Area;Biological Assay;Birth;Blood Vessels;Chronic;Chronic lung disease;clinically relevant;Complex;constriction;Critical Illness;Cyclooxygenase Inhibitors;cytotoxicity;Data;Databases;Development;Disease;Diuretics;drug candidate;Drug Combinations;Drug Exposure;Drug Screening;Drug toxicity;Drug usage;Ductus Arteriosus;Evaluation;Exposure to;Failure;fetal;fetal blood;Furosemide;gene network;Gentamicins;Grant;high risk infant;high throughput screening;Human;human data;human tissue;Hypoxia;Impairment;In Vitro;in vivo;innovation;interest;Kidney;Knowledge;Legal patent;Life;Ligation;Liquid substance;Mediating;modifiable risk;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;Muscle Contraction;Myography;Neonatal;neonatal human;Neonatal Intensive Care Units;neonatal mice;neonate;Newborn Animals;Newborn Infant;novel;Operative Surgical Procedures;Patent Ductus Arteriosus;Pathway interactions;permissiveness;Pharmaceutical Preparations;pharmacologic;Pharmacological Treatment;Pharmacopoeias;Phase;Physiological;postnatal;Pregnancy;premature;Premature Infant;prenatal exposure;pressure;preterm newborn;prevent;Property;Prostaglandin-Endoperoxide Synthase;Prostaglandins;Pulmonary artery structure;Relaxation;Research;Risk;Risk Factors;screening;seal;Sepsis;Series;Shunt Device;Signal Transduction;skills;Smooth Muscle;Smooth Muscle Myocytes;Stimulus;Testing;Therapeutic;Time;Toxic effect;Transfusion;translational potential;Uterus;Vasoconstrictor Agents;Vasodilator Agents;Woman

PROJECT_TITLE: Pharmacologic Contributors to Patent Ductus Arteriosus

STUDY_SECTION: PN

STUDY_SECTION_NAME: Pregnancy and Neonatology Study Section[PN]


ORG_CITY: LOS ANGELES

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE Intracranial aneurysms are extremely dangerous when they rupture. When one is detected, it may be treated or monitored through imaging, with aneurysm growth a strong indication of increased risk of rupture. This project will study how remodeling in the arteries of the Circle of Willis associates with aneurysm growth, and how blood flow may determine locations of remodeling, in order to identify new biomarkers to improve tracking and assessment of aneurysm progression.

PI_NAMEs: CHIEN, AICHI  (contact)

PROGRAM_OFFICER_NAME: LUO, JAMES

PROJECT_TERMS: Aneurysm;Angiography;Animal Model;Area;arterial tortuosity;Arteries;Autosomal Dominant Polycystic Kidney;Biochemical Process;biomarker identification;Blood flow;Blood Vessels;Caliber;Cell Death;cerebrovascular;Characteristics;Circle of Willis;Clinical;clinical risk;clinical translation;Dangerousness;Data;data modeling;Data Set;demographics;Disease;Disease Progression;Disproportionately impacts women;Extracellular Matrix;Family;Gender;Genetic;Geometry;Grant;Growth;hemodynamics;Human;Hypertension;Image;imaging biomarker;improved;Individual;Inflammation;innovation;Intracranial Aneurysm;Investigation;Length;Lesion;Link;Liquid substance;Location;Machine Learning;Medical History;Methods;Modeling;Monitor;mortality;novel;Outcome;patient oriented research;Patients;Pattern;Persons;Phenotype;Population;Prevalence;Process;Prospective cohort;Recording of previous events;Research;Risk;Risk Factors;risk stratification;Role;Rupture;sex;shape analysis;shear stress;side effect;Site;Speed;Statistical Models;Stroke;Subarachnoid Hemorrhage;Techniques;Testing;tool;Translating;translational study;United States;Validation;Vascular remodeling;Woman;Work

PROJECT_TITLE: Investigation of arterial changes in the Circle of Willis during intracranial aneurysm growth in humans

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


NIH_SPENDING_CATS: Brain Disorders;Childhood Injury;Epilepsy;Neurodegenerative;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Unintentional Childhood Injury

ORG_CITY: IOWA CITY

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it focuses on determining the pathways that lead to water accumulation during cytotoxic edema, a pathological state observed in multiple neurological injuries of the newborn, resulting in cell death and difficult to treat seizures. Once the pathways are identified, there is the potential for significant advancement in the treatment of neuronal swelling, which is currently lacking. The project is relevant to NIH’s mission that pertains to reducing illness and disability.

PI_NAMEs: GLYKYS, JOSEPH C. (contact)

PROGRAM_OFFICER_NAME: UMANAH, GEORGE KWABENA ESSIEN

PROJECT_TERMS: Age;Anions;Blindness;Blood flow;Brain;Brain Injuries;Cations;Cell Death;cell type;Cells;Cerebral Palsy;Childhood Injury;Chlorides;Cognitive;cytotoxic;Data;deafness;deep learning algorithm;deprivation;Development;disability;drug development;Drug Targeting;Edema;Epilepsy;Event;excitotoxicity;extracellular;fluorophore;Foundations;Future;genetic manipulation;Goals;Human;Hypoxia;Hypoxic-Ischemic Brain Injury;Imaging Techniques;improved;In Vitro;in vivo;Incidence;innovation;Ions;Knowledge;Link;Live Birth;Measures;Mediating;Metabolic;Mission;Morbidity - disease rate;Movement;multiphoton imaging;neonatal brain;neonatal hypoxic-ischemic brain injury;neonatal period;neonatal seizure;neonate;Nervous System Trauma;neuron loss;Neurons;Newborn Infant;novel;Osmolar Concentration;Outcome;Oxygen;Pathologic;Pathway interactions;Pharmaceutical Preparations;pharmacologic;Pharmacological Treatment;Positioning Attribute;prevent;Public Health;Regulation;Reproducibility;Research;Role;Seizures;Stroke;Swelling;symporter;Testing;Transgenic Mice;Trauma;Traumatic Brain Injury;United States National Institutes of Health;Water;water channel;water flow;Water Movements

PROJECT_TITLE: Water and chloride movement in neurons during seizure activity

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


NIH_SPENDING_CATS: Bioengineering

ORG_CITY: NEW YORK

ORG_DEPT: PHARMACOLOGY

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: PROJECT NARRATIVE Protein kinase signaling dynamics is highly heterogeneous in diseases such as cancer, but the biological origin and implications of such heterogeneity remain elusive. We plan to develop novel imaging probes and analytical methods for studying protein kinase signaling dynamics at single-cell resolution. Our results will help to understand the regulatory mechanisms that shape the kinetic patterns of protein kinase signaling activities and inform about therapeutic outcomes.

PI_NAMEs: XUE, MIN  (contact)

PROGRAM_OFFICER_NAME: HARTON, MARIE DEBORAHGAYNELLE

PROJECT_TERMS: Address;Affinity;AKT inhibition;analytical method;Behavior;Biological;Cell Line;Cells;Chemicals;Cyclic Peptides;Data;Disease;Epidermal Growth Factor Receptor;Glioblastoma;Heterogeneity;Human;imaging probe;insight;kinase inhibitor;Kinetics;Link;Malignant Neoplasms;Methods;Multivariate Analysis;neural network algorithm;novel;Outcome;Pattern;Pharmacotherapy;Phenotype;Phosphotransferases;Process;Protein Kinase;Proto-Oncogene Proteins c-akt;Reporting;Research;Resolution;response;Shapes;Signal Transduction;Signaling Protein;single cell technology;System;Technology;Testing;therapy outcome;tool;translational impact;Work

PROJECT_TITLE: Interrogation and interpretation of protein kinase signaling dynamics at single-cell resolution

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


NIH_SPENDING_CATS: Congenital Structural Anomalies;Digestive Diseases;Infectious Diseases;Kidney Disease;Pediatric;Rare Diseases

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

PHR: Project Narrative Activation of pattern recognition receptors initiates inflammatory signaling that is regulated by endocytosis. We have recently discovered that a protein that is mutated in patients of human ARC syndrome controls inflammatory responses induced by pattern recognition receptors by regulating endocytosis and phagocytosis. In this proposal we aim to study the molecular mechanisms by which this protein functions in cells of the innate immune system and the impact of its function on adaptive immunity.

PI_NAMEs: KRAMER, HELMUT J;PASARE, CHANDRASHEKHAR  (contact)

PROGRAM_OFFICER_NAME: KELLY, HALONNA R

PROJECT_TERMS: Acceleration;adaptive immunity;Affect;Antigen Presentation;Antigen Presentation Pathway;antimicrobial;Apoptotic;Arthrogryposis;Bacteremia;Bacteria;Bacterial Infections;Binding;C Type Lectin Receptors;CD8-Positive T-Lymphocytes;Cell membrane;Cell surface;cell type;Cells;Cessation of life;Cholestasis;Complex;cytokine;Data;Dendritic Cells;Development;Disease;Drosophila genus;Early Endosome;Endocytosis;Endosomes;Event;Exposure to;Failure;Family;fly;Genes;Germ Lines;Goals;Human;human disease;Humulus;Immune response;Immune signaling;Immunity;in vivo;Inflammation;Inflammatory;Inflammatory Response;Innate Immune Response;Innate Immune System;insight;Investigation;kidney dysfunction;Ligands;Link;Macrophage;Membrane Fusion;MHC Class II Genes;Microbe;microbial;Molecular;Mus;mutant;Mutate;Mutation;Natural Immunity;Necrosis;novel therapeutics;Outcome;paralogous gene;Pathway interactions;Patients;Pattern recognition receptor;Phagocytes;Phagocytosis;Phagosomes;Phosphotransferases;Play;protein function;Proteins;Publishing;receptor;Receptor Activation;Receptor Signaling;recruit;Recurrence;Regulation;response;Role;Sampling;Sepsis;Signal Transduction;Signal Transduction Pathway;Specificity;Symptoms;Syndrome;System;T cell response;Testing;TLR4 gene;Toll-like receptors;trafficking;Translating;unpublished works;Vertebrates

PROJECT_TITLE: Regulation of TLR signaling, Inflammation and Antigen Presentation by VPS33B


NIH_SPENDING_CATS: Genetics

ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: Narrative The goals of this proposal are to combine evolutionary and biochemical analysis to discover the genetic and structural mechanisms that caused the evolution of protein functions that play major roles in health and disease, including allosteric regulation of protein activity, formation of multimeric complexes, regulation of gene expression by transcription factors, and support for protein folding by chaperones. A better understanding of the genetic causes an consequence of protein evolution will allow more accurate interpretation of patterns of conservation and variability among modern-day proteins, improve our ability to predict the effects of genetic variation on health and disease, and aid in the design of proteins with desired properties.

PI_NAMEs: THORNTON, JOSEPH W (contact)

PROGRAM_OFFICER_NAME: ADKINS, RONALD

PROJECT_TERMS: Adopted;Affect;Allosteric Regulation;Area;Binding;Biochemical;Biological Assay;Biological Models;Biophysical Process;Biophysics;Case Study;Complex;Dependence;Disease;Event;Evolution;experimental study;fitness;Gene Expression Regulation;Genetic;Genetic Epistasis;Genetic Variation;Goals;Health;Hemoglobin;improved;insight;Knowledge;Lead;Libraries;Measures;Mediating;Modernization;Molecular;Molecular Chaperones;Molecular Evolution;Mutation;mutation screening;novel strategies;Outcome;Pattern;physical property;Play;Process;Property;Protein Biochemistry;protein complex;Protein Engineering;Protein Family;protein folding;protein function;Proteins;reconstruction;Recording of previous events;Role;Shapes;theories;Time;transcription factor;Work

PROJECT_TITLE: Genetic and biophysical causes of historical protein evolution

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: LEXINGTON

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: Project Narrative We have shown that neurotensin (NT), a hormone localized predominantly to the small bowel, acts as a “thrifty” gene to efficiently absorb ingested fats; NT deficiency in mice protects against obesity, insulin resistance and hepatic steatosis associated with high fat diet consumption. Moreover, we found that elevated NT levels in humans is strongly predictive of future obesity. Our current studies, which will define the mechanisms regulating NT-mediated intestinal lipid absorption and fat metabolism in liver and adipose tissues, will significantly impact the fields of GI physiology and metabolism and may eventually lead to innovative therapies for diet-induced obesity and resultant metabolic disorders based on inhibition of NT signaling.

PI_NAMEs: EVERS, BERNARD MARK (contact)

PROGRAM_OFFICER_NAME: SHEA-DONOHUE, TEREZ

PROJECT_TERMS: 5'-AMP-activated protein kinase;absorption;Adipocytes;Adipose tissue;Affinity;Amino Acids;Attenuated;Biochemistry;Biological Models;Biometry;blood glucose regulation;Body mass index;Body Weight decreased;Breast Cancer Risk Factor;cardiovascular disorder risk;Cells;Clinical;Computational Biology;Consumption;Development;Diabetes Mellitus;diet-induced obesity;Dietary Fats;Digestion;Disease;Disease Resistance;Distant;Drosophila genus;drug development;Endocrinology;Enteroendocrine Cell;Epidemiology;Epigenetic Process;experimental study;Fasting;Fatty acid glycerol esters;fatty acid oxidation;Fatty Acids;Fatty Liver;Future;Gastrointestinal Hormones;Gastrointestinal Physiology;Genes;Genetic;Goals;Grant;Growth;Hepatic;High Fat Diet;Homeostasis;Hormone Activity Inhibition;Hormones;Human;Ingestion;Innovative Therapy;insight;Insulin Resistance;Interdisciplinary Study;Intestinal Hormones;Intestinal Mucosa;Intestines;Knockout Mice;Knowledge;Laboratories;Length;Link;Lipase;lipid biosynthesis;lipid metabolism;Lipids;Lipolysis;Liver;Malignant neoplasm of gastrointestinal tract;Malignant Neoplasms;Mediating;Metabolic Diseases;Metabolism;metabolomics;Molecular;Morbidity - disease rate;mortality;mouse model;multidisciplinary;Mus;Neurotensin;Neurotensin Receptors;non-alcoholic fatty liver disease;novel;Nutrient;Obesity;obesity prevention;obesity treatment;Organ;Overnutrition;Physiological;Physiology;Play;Prevention;Process;Prognostic Marker;Publishing;Regulation;Reporting;Research;response;Role;Signal Pathway;Signal Transduction;Small Intestines;sortilin;sterol esterase;Stimulus;System;Technology;Time;Transgenic Organisms;Triglycerides;uptake;Weight Gain;Woman

PROJECT_TITLE: Mechanisms Regulating Neurotensin Secretion and Function

STUDY_SECTION: NMHD

STUDY_SECTION_NAME: Nutrition and Metabolism in Health and Disease Study Section[NMHD]


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases

ORG_CITY: SAN DIEGO

ORG_NAME: CALIFORNIA MEDICAL INNOVATIONS INSTITUTE

PHR: NARRATIVE Defecatory disorders are common and poorly diagnosed and treated. Our goals are to understand defecation reflex in normal subjects and patients suffering from chronic constipation using a novel electronic simulated stool (Fecobionics), a device that maps geometric and manometric profiles during the defecation/evacuation process.

PI_NAMEs: GREGERSEN, HANS  (contact);KASSAB, GHASSAN S

PROGRAM_OFFICER_NAME: UNALP-ARIDA, AYNUR

PROJECT_TERMS: abdominal pressure;abdominal wall;Affect;American;Anal canal;anorectal disorder;Anus;Area;Barium;biomechanical model;Biomechanics;Chronic;Circular layer of muscularis propria of anal canal;clinical decision-making;Colorectal;Constipation;cost;Data;Defecation;Defecography;Defect;Development;Devices;Diagnosis;Diagnostic;Diagnostic tests;Disease;driving force;Electromyography;Electronics;Etiology;Event;Expenditure;External anal sphincter structure;Feces;Friction;Functional disorder;Future;Geometry;Goals;Health;Health Care Costs;Human;improved;Incidence;Innovative Therapy;insight;Intra-abdominal;Knowledge;Laboratories;laxative;Length;Location;Manometry;Maps;mathematical model;Medicine;Methods;Modality;Motility;motility disorder;Motor;Muscle;North America;novel;novel therapeutic intervention;outcome prediction;Patients;Pattern;Pelvic Floor Muscle;Peristalsis;Persons;Physiological;Physiology;Play;Population;pressure;Privatization;Process;Property;Radiation;Records;Rectum;Reflex action;Relaxation;Research;Resolution;Risk;Role;Sensory;Shapes;Skeletal Muscle;Smooth Muscle;Sphincter;sphincter ani muscle structure;Stress;Symptoms;System;Test Result;Testing;Therapeutic;Thinking;Time;tool;Treatment outcome;treatment strategy;Valsalva Maneuver;viscoelasticity;wireless

PROJECT_TITLE: Defecation mechanisms and subtyping of constipation patients with Fecobionics

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-A(90)]


NIH_SPENDING_CATS: Neurosciences;Nutrition;Obesity

ORG_CITY: NEW HAVEN

ORG_DEPT: PHYSIOLOGY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE The proposed project aims to elucidate which brain nuclei underlie the response to changes in whole body thermogenesis. This work will improve our understanding on thermogenesis identifying the molecular identity of neurons in premotor areas driving a thermogenic response, which could lead to the development of novel, cell type specific efficacious therapies for treating obesity. Furthermore, direct manipulation of identified neuronal subtypes will provide unprecedented information of how the coordinated sympathetic nervous system mediated thermogenesis response is produced.

PI_NAMEs: SCHNEEBERGER, MARC  (contact)

PROGRAM_OFFICER_NAME: COOKE, BRAD

PROJECT_TERMS: Address;Affect;American;Anatomy;Area;Automobile Driving;Back;Behavioral Mechanisms;Body Temperature;Brain;Brain Stem;Brown Fat;Calcium;career;Cell Nucleus;cell type;Cells;Central Nervous System;Clinical;Data;Development;Disease;dorsal raphe nucleus;Eating;effective therapy;efficacious treatment;Energy Metabolism;Environment;Epidemic;experimental study;Exposure to;feeding;Future;Genetic;genetic approach;Goals;Health;Heart;heart function;Heterogeneity;Homeostasis;Human;Hypothalamic structure;Image;improved;in vivo calcium imaging;interdisciplinary approach;Laboratories;Lung;mad itch virus;Mammals;Maps;Mediating;Mentors;Metabolic;Metabolic dysfunction;Metabolism;Methods;Molecular;molecular marker;molecular phenotype;Molecular Profiling;Motor;Motor Activity;Motor Neurons;nerve supply;neural;neural circuit;neuronal patterning;Neurons;Neurosciences;novel;novel therapeutics;Obesity;obesity treatment;optogenetics;Outcome;Peripheral;Peripheral Nervous System;Pharmacology;Phase;Physiologic Thermoregulation;Population;Process;pulmonary function;Regulation;Research;Research Personnel;response;Role;Shivering;Skin;Sympathetic Nervous System;System;Technology;Temperature;Testing;Thermogenesis;Tissues;Training;Validation;Vasodilation;Viral;Work

PROJECT_TITLE: Understanding how the thermogenic response is orchestrated in the central nervous system

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Immunization;Infectious Diseases;Orphan Drug;Prevention;Rare Diseases;Vaccine Related

ORG_CITY: BALTIMORE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PHR: Program Director/Principal Investigator (Last, First, Middle): Barry, Eileen M. Project Narrative: This project proposes to perform cGMP production, and IND-enabling pre-clinical studies of two lead live, attenuated Shigella-ETEC vaccine candidates that constitute essential components of a broadly protective vaccine against two priority enteropathogens. This work is required for advancement to clinical trials and eventual deployment to multiple at-risk populations in urgent need of novel interventions. OMB No. 0925-0001/0002 (Rev. 03/2020 Approved Through 02/28/2023) Page Continuation Format Page

PI_NAMEs: BARRY, EILEEN M. (contact);CHEN, WILBUR H.

PROGRAM_OFFICER_NAME: BAQAR, SHAHIDA

PROJECT_TERMS: Advanced Development;Animal Model;Antigens;Antimicrobial Resistance;Attenuated;Attenuated Vaccines;Biological Products;burden of illness;cell bank;Child;Chromosomes;Clinical;Clinical Trials;colonization factor antigens;Combined Vaccines;Consultations;Data;Dedications;Developing Countries;Development;Diarrhea;diarrheal disease;Disease;Documentation;Engineering;Ensure;enteric pathogen;enterotoxigenic Escherichia coli;Enterotoxins;Escherichia coli Vaccines;Excretory function;experience;Fermentation;Formulation;Funding;Funding Mechanisms;Genes;Goals;Good Manufacturing Process;Human;Immune response;immunogenic;immunogenicity;In Vitro;in vivo;Industrialization;Intervention;Investigational Drugs;Laboratory Research;Lead;lot production;manufacture;Military Personnel;Mission;Modification;National Institute of Allergy and Infectious Disease;novel;Organism;pathogen;Pattern;Performance;Phase I Clinical Trials;Phase II Clinical Trials;Plasmids;Population;Populations at Risk;pre-clinical;preclinical study;prevent;Principal Investigator;Procedures;Process;Production;programs;protective efficacy;prototype;research clinical testing;Research Institute;Safety;scale up;Series;Shigella;Shigella flexneri;Shigella sonnei;Shigella Vaccines;success;Target Populations;Testing;Toxin;Translating;vaccine candidate;vaccine development;vaccine distribution;vaccine immunogenicity;Vaccine Production;Vaccines;Vial device;Virulence;Visit;Vulnerable Populations;Work

PROJECT_TITLE: Advanced Development of a Combined Shigella-ETEC Vaccine


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Physical Activity;Prevention;Sleep Research;Social Determinants of Health

ORG_CITY: PROVIDENCE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: PROJECT NARRATIVE Findings from this study will allow us to determine (1) how green space utilization (GPS-derived measures of daily activity and environmental features) is related to sleep (duration, timing, regularity) in children, (2) Determine whether greenspace utilization is associated with mental health and wellbeing via sleep behaviors and (3) Explore the potential epigenetic contribution of greenspace on sleep and wellbeing in children.

PI_NAMEs: GRIGSBY, DIANA SYLVIA (contact)

PROGRAM_OFFICER_NAME: LINARES, DEBORAH ELIZABETH

PROJECT_TERMS: Accelerometer;actigraphy;Address;Adolescent;Adult;Affect;Age;Anxiety;Attention deficit hyperactivity disorder;biological adaptation to stress;Child;Childhood;Cities;cognitive function;contextual factors;Data;Development;DNA Methylation;Economic Burden;Education;elementary school;Epigenetic Process;Excessive Daytime Sleepiness;Exposure to;Family;Foundations;Genes;genome-wide;geographic difference;Green space;Health;health assessment;Health Benefit;Home;improved;improvement on sleep;Interleukin-1 beta;Light;Link;Measurement;Measures;Mental disorders;Mental Health;Mental health promotion;Methodology;novel;Outcome;Pathway interactions;Pattern;peer;Personal Satisfaction;Physical activity;physical conditioning;Play;policy implication;Psychological Stress;Public Health;recruit;response;Rhode Island;risk sharing;Role;Sampling;Sleep;sleep behavior;Sleep Deprivation;sleep health;sleep pattern;social health determinants;Socioeconomic Factors;State Interests;Stress;stress reduction;Survey Methodology;Symptoms;Time;Trees;Well in self;Work

PROJECT_TITLE: Green Space, Mental Health and Sleep

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


NIH_SPENDING_CATS: Bioengineering;Breast Cancer;Cancer;Clinical Research;Genetics;Women's Health Research

ORG_CITY: AMHERST

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

ORG_STATE: NY

PHR: Project Narrative Basal cancer is a complex and deadly subtype of breast cancer. In this study, we will combine next-generation sequencing technology and advanced computational methods to address some pressing issues and unmet clinical needs of basal cancer, including those related to 1) the derivation of accurate prognostic evaluation systems, 2) the delineation of the dynamic disease development process through progression modeling, and 3) the identification of pivotal, driving molecular events that present therapeutic opportunities. If successfully implemented, this study can significantly advance the basal cancer research, and pave the way for applying similar strategies to study other deadly cancers.

PI_NAMEs: GOODISON, STEVE ;SUN, YIJUN  (contact)

PROGRAM_OFFICER_NAME: MILLER, DAVID J

PROJECT_TERMS: Address;American Society of Clinical Oncology;anti-cancer research;Area;Automobile Driving;Bioinformatics;Biological Process;Cancer Patient;Cancer Prognosis;Cause of Death;chemotherapy;Classification;Clinic;Clinical;Clinical Management;Clinical Research;Complex;Computational Technique;Computing Methodologies;Data;Data Set;Derivation procedure;Development;Disease;Disease-Free Survival;DNA Sequence Alteration;DNA sequencing;ERBB2 gene;Estrogen Receptors;Evaluation;Event;Evolution;Experimental Designs;Future;Genes;Genetic;genetic association;Genetic Determinism;Genomic Instability;Guidelines;high risk;indexing;insight;Institution;Interdisciplinary Study;Learning;Life;Machine Learning;Malignant - descriptor;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Neoplasms;Methods;Modeling;Molecular;Molecular Profiling;molecular subtypes;multidisciplinary;Multiomic Data;Neoplasm Metastasis;next generation sequencing;novel;Outcome;Pathology;Pathway interactions;Patients;Pattern;Prevalence;Primary Neoplasm;Process;Progesterone Receptors;prognostic;prognostic assays;prognostic model;prognostication;prospective;Recurrence;Resolution;Role;Sampling;Series;Specimen;Structure;System;targeted treatment;Technology;theories;Therapeutic;therapeutic target;Tissue Banks;tissue mapping;transcriptome sequencing;Treatment Protocols;tumor;Tumor Biology;tumor progression;Tumor Tissue;tumorigenesis;Visualization;Woman;Work

PROJECT_TITLE: Prognostic analysis and progression modeling of basal-like breast cancer using multi-region sequencing

STUDY_SECTION: BDMA

STUDY_SECTION_NAME: Biodata Management and Analysis Study Section[BDMA]


NIH_SPENDING_CATS: Hematology;Social Determinants of Health

ORG_CITY: LITTLE ROCK

ORG_NAME: UNIV OF ARKANSAS FOR MED SCIS

ORG_STATE: AR

PHR: PROJECT NARRATIVE Arkansas is primarily a rural state that has a growing number of individuals living at or below the poverty level with limited access to health care, and many of these individuals are members of minority groups who face health care disparities that could potentially be reduced through health care workforce diversity. The goal of this project is to assist in increasing diversity among biomedical sciences' health professional students and faculty. Establishing a diverse biomedical science workforce will result in improved quality of medical education, improved access to health care for underserved populations, and accelerated advances in medical and public health research, as well as a reduction in health care disparities and improved public health.

PI_NAMEs: MCGEHEE, ROBERT E;THOMAS, BILLY R (contact)

PROGRAM_OFFICER_NAME: SIDDIQUI, AYESHA SAEED

PROJECT_TERMS: Acceleration;Address;Area;Arkansas;Bachelor's Degree;Basic Science;Cardiovascular system;career;Clinical Research;Communication;Continuing Education;Data;Degree program;design;Disadvantaged;disadvantaged student;Enrollment;Ensure;Evaluation;experience;Faculty;faculty mentor;Familiarity;formative assessment;Fostering;Foundations;Funding;Goals;Graduate Degree;graduate school;Health;health care availability;health care disparity;Health Occupations;Health Professional;Health Sciences;Healthcare;Hematology;higher education;Hour;Improve Access;improved;Individual;Institution;interest;Leadership;lecturer;lectures;Letters;Life;Lung;Medical;Medical Education;medical schools;member;Mentors;Minority Groups;Mission;National Heart, Lung, and Blood Institute;Operative Surgical Procedures;Oral;Outcome;Paper;Participant;Positioning Attribute;posters;Poverty;professional students;programs;Public Health;public health research;Recommendation;recruit;Reporting;Research;Research Personnel;Research Project Grants;responsible research conduct;Rewards;Rural;satisfaction;Schools;Science;Services;Site;skills;Students;success;summer program;summer research;symposium;Talents;Techniques;Training;Translational Research;undergraduate research experience;undergraduate student;Underrepresented Populations;Underrepresented Students;Underserved Population;United States National Institutes of Health;Universities;Work;Writing

PROJECT_TITLE: UAMS Summer Undergraduate Research Program to Increase Diversity in Research


ADMINISTERING_IC: VA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: Veterans Affairs

ORG_CITY: WEST HAVEN

ORG_NAME: VA CONNECTICUT HEALTHCARE SYSTEM

PHR: The healthcare system plays an integral role in the detection of intimate partner violence (IPV), a complex public health crisis with far-reaching consequences. Although the focus of IPV screening implementation at VHA to date has targeted women Veterans of reproductive age, the national IPV Assistance Program (IPVAP) is expanding IPV screening to Veterans of all genders and ages through a national rollout. Evaluating the implementation and clinical impact of this rollout, with a primary focus on identifying potential gender differences, is a critical priority for IPVAP. This robust and highly-partnered evaluation will (1) extend prior research conducted primarily with women Veterans; (2) provide critically needed clinical data to enhance and inform national programming; (3) result in the development of data systems essential for monitoring screening; and (4) lead to optimization of future IPV screening implementation strategies.

PI_NAMEs: PORTNOY, GALINA ALEXANDRA (contact)

PROJECT_TERMS: Age;Aggressive behavior;Area;Back;Caring;Characteristics;Clinical;Clinical Data;Clinical effectiveness;Collaborations;Complex;Consolidated Framework for Implementation Research;Data;data warehouse;Detection;Development;Disclosure;Electronic Health Record;Ethnic Origin;Evaluation;experience;Family;Funding;Future;Gender;gender difference;Goals;Health;Health Services;Healthcare;Healthcare Systems;implementation evaluation;implementation framework;implementation outcomes;implementation strategy;improved;Informatics;Information Systems;innovation;Interview;intimate partner violence;Lead;Maintenance;male;Marital Status;member;men;Monitor;Outcome;patient population;patient screening;Patient-Focused Outcomes;Patients;Play;Population;primary care setting;Process;programs;Protocols documentation;Provider;Psychiatric Social Work;psychologic;Public Health;Qualitative Methods;Race;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;Recording of previous events;reproductive;Research;research clinical testing;Research Personnel;Resources;response;Risk;Role;routine screening;Safety;satisfaction;scale up;Scientist;screening;service utilization;Sex Orientation;Strategic Planning;System;Time;tool;United States Preventative Services Task Force;Update;uptake;Veterans;Veterans Health Administration;Woman;Work

PROJECT_TITLE: Evaluating the Implementation and Impact of the Updated Relationship Health and Safety Screening National Rollout


FUNDING_MECHANISM: OTHERS

ORG_NAME: PROVIDENCE VA  MEDICAL CENTER

PHR: Linda Resnik is a physical therapist researcher whose work links the fields of rehabilitation and health services research. She focuses on three research areas: 1) design and evaluation of upper limb prosthetic devices; 2) development, evaluation, and deployment of rehabilitation outcomes measures; 3) study of delivery and effectiveness of rehabilitation services. Her research involves extensive relationships with clinician scientists, investigators, and VA clinical program leaders to maximize dissemination and implementation of findings.

PI_NAMEs: RESNIK, LINDA J. (contact)

PROJECT_TERMS: Acute;Adoption;Amputation;Amputees;Area;arm;Articular Range of Motion;Atlases;Award;Benchmarking;Books;Calibration;care delivery;career;Caring;Chairperson;Chronic;Classification;Clinical;clinical practice;Clinical Practice Guideline;Clinical Protocols;clinical translation;Clinical Trials;Collaborations;Community Integration;community reintegration;comparative effectiveness;compare effectiveness;Computers;Data;design;Development;Devices;disability;Disabling condition;Dissemination and Implementation;Educational Curriculum;Effectiveness;Evaluation;experience;Food and Drug Administration Device Approval;Foundations;Goals;Hand;Health;Health Services;Health Services Research;Health system;Home;Homogeneously Staining Region;improved;indexing;International;Internet;kinematics;Lead;Learning;limb amputation;limb injury;Link;Lower Extremity;Measurement;Measures;meetings;member;Mentors;Methodology;Methods;National Institute of Child Health and Human Development;neural;novel;Outcome;Outcome Measure;Patient Self-Report;Patients;Pattern Recognition;Peer Review;Performance;Peripheral;Persons;Physical Function;physical therapist;Physical therapy;Policies;Principal Investigator;programs;Prosthesis;prosthesis wearer;Protocols documentation;Provider;Proxy;psychosocial adjustment;Publications;Quality of life;Rehabilitation Outcome;rehabilitation research;rehabilitation service;Rehabilitation therapy;rehabilitative care;Reporting;Research;Research Personnel;residual limb health;Risk Adjustment;satisfaction;Science;Scientist;Self-Help Devices;sensory prosthesis;sex;Shapes;Site;Suspensions;systematic review;Taxonomy;Technology;Testing;tool;Training;Translational Research;Traumatic Brain Injury;United States National Academy of Sciences;Upper Extremity;US Army Medical Research and Material Command;Veterans;Weight;Woman;Work;working group;wounded service member

PROJECT_TITLE: RR&D Research Career Scientist Award Application

STUDY_SECTION_NAME: Research Career Scientist[RRD7]


ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Immediate hypersensitivity reactions to drugs, foods, and other substances are diagnosed clinically based on symptoms, which is problematic due to a wide range of presentations, underlying mechanisms, and overlap with other disorders. Unfortunately, current known biomarkers are not sensitive enough to useful in all contexts of acute allergic reactions. This project will investigate the utility of circulating plasma extracellular vesicles as biomarkers for acute hypersensitivity reactions, which will provide clinicians with new tools for diagnosing these conditions.

PI_NAMEs: DISPENZA, MELANIE C. (contact)

PROGRAM_OFFICER_NAME: DONG, GANG

PROJECT_TERMS: accurate diagnosis;Acute;Adult;Allergic;Allergic Reaction;allergic response;Anaphylaxis;aspirin-exacerbated respiratory disease;Award;Basophils;biobank;Biochemistry;Biological Markers;Blood specimen;Cell membrane;Cells;chronic rhinosinusitis;Clinical;clinical diagnosis;Clinical Research;Clinical Trials;Data;Development;Diagnosis;Diagnostic;diagnostic biomarker;Disease;Drug Hypersensitivity;Enrollment;Evaluation;Exercise;extracellular vesicles;Food;food challenge;Food Hypersensitivity;Future;Grant;Hypersensitivity;IgE;Immediate hypersensitivity;in vivo;Infusion procedures;Insecta;insight;Intervention;K-Series Research Career Programs;Laboratories;Life;mast cell;Mediating;Mediator;Medical;microvesicles;Nasal Lavage Fluid;National Institute of Allergy and Infectious Disease;NIH Program Announcements;novel diagnostics;novel marker;Oral;Outpatients;participant enrollment;Patients;Perioperative;peripheral blood;Pharmaceutical Preparations;Plasma;Plasma Cells;programs;Qualifying;Reaction;receptor;Research;Research Project Grants;Resources;response;Sampling;Serum;Severities;Signs and Symptoms;Specimen;Surface;Symptoms;Syndrome;Techniques;Technology;tool;Tryptase;Vaccines;Vancomycin;Venoms;vesicular release

PROJECT_TITLE: Extracellular Vesicles as Biomarkers of Immediate Hypersensitivity Reactions

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IIDA-F (57)]


NIH_SPENDING_CATS: Clinical Research;Genetics;Lung;Neonatal Respiratory Distress;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Rare Diseases

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: PROJECT NARRATIVE Bronchopulmonary dysplasia (BPD) is a lung disease that affects infants born extremely premature, especially those that require mechanical ventilation. Type 1 pulmonary epithelial (AT1) cells are large gas-exchanging cells that are placed at a crucial interface of the outside environment and the underlying developing lung and have been recently found to be key contributors to the pulmonary matrisome. This proposal will identify how biophysical force on AT1 cells impacts matrisome-related gene expression and communication across the developing lung that predisposes to BPD and related comorbidities.

PI_NAMEs: CALLAWAY, DANIELLE ARDEN (contact)

PROGRAM_OFFICER_NAME: REYES, MADELYN

PROJECT_TERMS: Acute;Address;Advisory Committees;Affect;Air;Alveolar;alveolar epithelium;Architecture;Attenuated;base;Bioinformatics;Biophysics;Blood capillaries;Breathing;Bronchopulmonary Dysplasia;career;career development;Cell Communication;Cell Compartmentation;Cell Lineage;Cell model;Cell Physiology;Cell Reprogramming;Cells;Cellular biology;Clinical;Clinical Research;Communication;comorbidity;Competence;Critical Pathways;Data;Development;Developmental Biology;Disease;Educational workshop;Embryo;Environment;Epigenetic Process;Epithelial Cells;Equilibrium;Etiology;Exposure to;Extracellular Matrix;extreme prematurity;Funding;Future;Gases;Gene Expression;Generations;genetic regulatory protein;Genetic Transcription;Goals;Growth;Health;Hyperoxia;Impairment;In Vitro;in vitro Model;in vivo;Incidence;Infant;Injury;innovation;insight;instructor;Integrins;intercellular communication;Laboratories;life span;Ligands;Lung;lung development;Lung Diseases;lung injury;lung regeneration;lymphatic dysfunction;Maps;Mechanical Stress;Mechanical ventilation;Mediating;member;Mentorship;Modeling;Molecular;Molecular Biology;Motion;mouse model;multicatalytic endopeptidase complex;Mus;Natural regeneration;Neonatal lung;neonatal mice;neonate;Neonatology;novel;Oxidative Stress;Pathogenesis;Pathologic;Patients;pediatric department;Pediatric Hospitals;Pennsylvania;Phenotype;Philadelphia;Physicians;potential biomarker;premature;Premature Infant Diseases;prevent;Process;Production;Productivity;Program Development;programs;Pulmonary Hypertension;receptor;Regulation;Research;Research Personnel;Resistance;response;Risk;Role;Scientist;Severities;Signal Pathway;Signal Transduction;single cell ATAC-seq;single-cell RNA sequencing;Stress;Stretching;success;Testing;Therapeutic;Thick;Training;Training Programs;transcriptome;transcriptomics;Transforming Growth Factor beta;Transgenic Mice;Translating;United States National Institutes of Health;Universities;Up-Regulation;Ventilator;Work

PROJECT_TITLE: Biophysical force affects type 1 alveolar epithelial cell-mediated regulation of the pulmonary matrisome and lung development

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-F (J3)]


NIH_SPENDING_CATS: Cancer;Genetics;Prostate Cancer;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Urologic Diseases

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE Prostate cancer becomes an incurable lethal disease once it disseminates to distant organs and progresses to standard therapies. The proposed studies using patient datasets, mouse and patient-derived models will uncover targetable transcriptional mechanisms that contribute to lethal prostate cancer pathobiology. The molecular dissection of these mechanisms has the potential to generate effective therapeutic approaches for prostate cancer patients.

PI_NAMEs: DOMINGO-DOMENECH, JOSEP MARIA (contact);RODRIGUEZ-BRAVO, VERONICA

PROGRAM_OFFICER_NAME: GREENBERG, WILLIAM A

PROJECT_TERMS: advanced disease;Androgen Receptor;anti-cancer;Biological Process;cancer cell;Cancer Etiology;Cancer Patient;Cell Physiology;Cell Survival;Cells;Cessation of life;chemotherapy;Chromatin;Clinical;clinically relevant;Data;Data Set;Development;Disease;Disease Progression;Dissection;Distant;efficacy study;Endothelium;Epigenetic Process;GATA2 transcription factor;Gene Expression;Genes;Genetic;Genetic Transcription;Hematopoietic stem cells;Human;IGF2 gene;improved;in vivo;inhibitor;innovation;Knock-in Mouse;Malignant neoplasm of prostate;Malignant Neoplasms;men;Modeling;Molecular;Motility;mouse model;Mus;Neoplasm Circulating Cells;Neoplasm Metastasis;novel;novel therapeutic intervention;novel therapeutics;Nuclear Import;Nuclear Pore Complex Proteins;Organ;Outcome;Pathogenesis;Pathway interactions;Patients;pharmacologic;Phenotype;Play;pre-clinical;preclinical efficacy;Process;programs;Proliferating;Prostate;prostate cancer cell;prostate cancer metastasis;prostate cancer model;prostate cancer progression;receptor binding;Resistance;Role;Sampling;Signal Pathway;Signal Transduction;single cell analysis;small molecule;small molecule inhibitor;stem;stem cell homeostasis;stem-like cell;stemness;Therapeutic;Therapeutic Agents;therapeutic target;therapeutically effective;therapy resistant;transcription factor;Transcriptional Regulation;transcriptomics;Transgenic Organisms;Translating;tumor;Undifferentiated;United States;Up-Regulation

PROJECT_TITLE: Mechanisms and therapeutic targeting of lethal prostate cancer master regulator transcription factors

STUDY_SECTION: MCTA

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics A Study Section[MCTA]