NIH_SPENDING_CATS: Genetics;Lung;Orphan Drug;Pulmonary Hypertension;Rare Diseases

ORG_CITY: LOS ANGELES

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE Patients suffering from PAH (pulmonary arterial hypertension) are young and have a poor life quality and a short life expectancy despite current treatments. Recent advances showed that PAH arose from a genome-wide deregulation of gene expression. In this proposal, we aim to explore the therapeutic potential of RNA-binding proteins in PAH through the integration of computational and experimental approaches.

PI_NAMEs: EGHBALI, MANSOUREH  (contact)

PROGRAM_OFFICER_NAME: SUTLIFF, ROY L

PROJECT_TERMS: Amphiregulin;Apoptosis;Apoptotic;Binding;Biological Markers;Biology;carcinogenesis;Cell Cycle;Cell Proliferation;Cells;Characteristics;chromatin immunoprecipitation;Chronic;Circulation;Complex;Computational Biology;Data;Disease;DNA damage checkpoint;DNA Repair;Endothelial Cells;Epidermal Growth Factor Receptor;Event;experimental study;Feedback;Fibroblasts;Gene Expression;Gene Expression Regulation;Genes;genome-wide;Human;human subject;Hypoxia;In Vitro;innovation;Investigation;Lead;Life Expectancy;Link;Lung;Manuscripts;Messenger RNA;Metabolic;Modeling;Mutate;novel therapeutics;Oncogene Deregulation;Patients;Phenotype;Plasma;prevent;Proliferating;promoter;Proteins;Publishing;pulmonary arterial hypertension;pulmonary arterial pressure;pulmonary artery endothelial cell;Pulmonary Hypertension;pulmonary vascular disorder;Quality of life;Rattus;receptor;Recombinants;Resistance;RNA Splicing;RNA-Binding Proteins;Role;Sampling;Severities;Sister Chromatid;Smooth Muscle Myocytes;Therapeutic;therapeutic target;Transcript;transcription factor;transcriptomics;Translations;Up-Regulation;Zinc Fingers

PROJECT_TITLE: ZFP36, an RNA Binding Protein that Regulates DNA Repair and Cell Proliferation in PAH

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


ADMINISTERING_IC: GM

ARRA_FUNDED: N

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: RIVERSIDE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CALIFORNIA RIVERSIDE

ORG_STATE: CA

PHR: PROJECT NARRATIVE The amount of genetic shuffling due to meiotic recombination each generation (i.e., recombination rate) has profound effects on patterns of inheritance and is a key modulator of evolutionary processes such as adaptation and speciation. Despite its wide-ranging importance across many domains of biology, we have a poor understanding of how and why recombination rate varies across biological scales. To address this gap, my lab will shed light on the genetic and evolutionary causes and consequences of recombination rate variation in natural populations by testing long-standing hypotheses using modern genomic tools.

PI_NAMEs: SAMUK, KIERAN  (contact)

PROGRAM_OFFICER_NAME: ADKINS, RONALD

PROJECT_TERMS: 2019-nCoV;Address;Biological;Biological Models;Biology;Chromosome inversion;Clustered Regularly Interspaced Short Palindromic Repeats;Computational Biology;Congenital chromosomal disease;Disease;Down's Syndrome;Drosophila genus;Engineering;Eukaryota;Evolution;Gasterosteidae;Generations;Genetic;Genetic Nondisjunction;Genetic Recombination;genome-wide;genomic tools;Genomics;Germ Cells;Human;Human Resources;Inheritance Patterns;Klinefelter's Syndrome;Maps;Mechanics;Mediating;Meiotic Recombination;Modeling;Modernization;novel;Pattern;Population;Process;programs;Reproduction;Research;Resources;Role;Statistical Methods;Techniques;Technology;Testing;tool;Training;user-friendly;Variant;Vertebrates;Work

PROJECT_TITLE: The evolution and genetics of recombination rate variation

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Diabetes;Prevention

ORG_CITY: STANFORD

ORG_DEPT: PEDIATRICS

ORG_NAME: STANFORD UNIVERSITY

PHR: This project proposes to develop non-peptide ligands that activate insulin receptors, offering a new approach for glycemic control in diabetes management. Combining advanced computational design, collaborative expertise, and innovative drug development techniques, the research aims not only to introduce a transformative therapeutic option but also to significantly enhance the quality of life for individuals with diabetes.

PI_NAMEs: CHOU, DANNY HUNG-CHIEH (contact)

PROGRAM_OFFICER_NAME: SECHI, SALVATORE

PROJECT_TERMS: Address;alternative treatment;Binding Sites;Chronic;Dedications;design;Development;diabetes management;Diabetes Mellitus;drug development;Generations;glycemic control;Health;improved;Individual;innovation;insight;Insulin;Insulin Receptor;Ligands;next generation;novel;novel strategies;Oral Administration;Outcome;Outcomes Research;Quality of life;receptor;Research;Research Project Grants;technique development;Therapeutic

PROJECT_TITLE: Beyond insulin: Next-generation modulators of insulin receptor for glycemic control

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-S (M3)]


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Digestive Diseases;Nutrition

ORG_CITY: STOCKTON

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF THE PACIFIC-STOCKTON

PHR: PROJECT NARRATIVE In this proposal, we will characterize the interactions between Pichia pastoris, a protein expression system, and C57BL/6 mice to determine the extent to which P. pastoris can colonize the murine gastrointestinal tract. Our goal is to have P. pastoris survive in the murine gut and secrete β-galactosidase to aid the digestion of ingested lactose. Results from this project will demonstrate the potential of P. pastoris to express other recombinant proteins in the digestive tract of living organisms to either investigate protein function or to be used as therapeutic proteins.

PI_NAMEs: THOR, DER  (contact)

PROGRAM_OFFICER_NAME: BERNAL, FEDERICO

PROJECT_TERMS: 3T3 Cells;Adult;Affinity;Animal Diseases;Animals;Anti-Inflammatory Agents;antimicrobial;Behavior;beta-Galactosidase;Binding;Biological Markers;Biological Products;Body Weight;Body Weight decreased;Bypass;C57BL/6 Mouse;Cecum;Collaborations;Colon;Consumption;cost;Data;Diet;Digestion;Digestive System Disorders;Disease;DNA;Dose;Endothelial Cells;Energy-Generating Resources;Engineering;Enzyme-Linked Immunosorbent Assay;Enzymes;Epithelial Cells;Exhibits;Feces;feeding;Female;FGF2 gene;Fibroblast Growth Factor;Fibroblasts;gastrointestinal;Gastrointestinal Contents;Gastrointestinal tract structure;genetic manipulation;Goals;Green Fluorescent Proteins;Growth;gut microbes;Histologic;Histology;Hour;Human;immunogenicity;improved;Inflammation;inflammatory marker;Inflammatory Response;Ingestion;Interferon Type II;Investigation;Lactase;Lactose;Lactose Intolerance;Leukocyte L1 Antigen Complex;male;Mammalian Cell;Measurable;Microscopy;Modeling;Morphology;mouse model;Movement;Mucins;Mucous body substance;Mus;NIH 3T3 Cells;old mice;Oral;Oral cavity;Organism;Pichia;Pilot Projects;Prevention;Probiotics;protein expression;protein function;Protein Secretion;Proteins;recombinant peptide;Recombinant Proteins;Recombinants;Reporting;Role;Saccharomyces;Small Intestines;stool sample;System;Testing;Therapeutic;Therapeutic Agents;therapeutic protein;Therapeutic Uses;Time;tissue culture;Tissues;TNF gene;treatment duration;treatment effect;treatment strategy;Vaccines;Weight;Yeasts

PROJECT_TITLE: Characterization of colonization and protein secretion by Pichia pastoris in the gastrointestinal tract of mice

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 SPJ-D (M1)]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Building Research Capacity at Institutions with Limited NIH Funding;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: POCATELLO

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: IDAHO STATE UNIVERSITY

ORG_STATE: ID

PHR: Narrative The study of brain recordings can more effectively be pursued by employing machine learning methods that are based on nonlocal equations, due to the highly complex dynamics of the brain. We propose to use models based on integral equations (highly nonlocal) to model and predict brain dynamics. Such models are explainable, in the sense that the self-attention weights of the model can be used to characterize brain dynamics, and therefore develop diagnosis scores.

PI_NAMEs: ZAPPALA, EMANUELE  (contact)

PROGRAM_OFFICER_NAME: REVILLEZA, MARIA

PROJECT_TERMS: Algorithms;Applications Grants;Attention;Brain;cardiac magnetic resonance imaging;Characteristics;Classification;Cognition;Cognitive;Complex;Data;Data Set;Development;Diagnosis;Diagnostic;Differential Equation;Disease;Equation;Fingerprint;Follow-Up Studies;Functional Magnetic Resonance Imaging;Integral Equation;Learning;Machine Learning;machine learning algorithm;machine learning method;Maps;Medical;Medical Records;Mental Depression;Methodology;Methods;Modeling;Nervous System Disorder;Neurologic;Pathologic;Pathology;Patients;Physicians;Process;Property;self-attention;Severities;spatiotemporal;Structure;theories;Training;Video Recording;Visualization;Weight

PROJECT_TITLE: Using integral equations to capture spatiotemporal relations in the brain

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 RCB-T (SF)]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Gene Therapy;Genetics;Immunotherapy;Neurosciences;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative: Proficiency of macrophages and microglia to infiltrate malignant brain tumors provides a unique opportunity to exploit their phagocytic properties by engineering the activation of these professional phagocytes using exogenous expression of Chimeric Antigen Receptor (CARs) targeted towards a brain tumor-specific antigen.

PI_NAMEs: MITRA, SIDDHARTHA S. (contact)

PROGRAM_OFFICER_NAME: HU, ZHANG-ZHI

PROJECT_TERMS: Adoptive Transfer;Adult;Anaplastic astrocytoma;Anti-CD47;Antibody Specificity;Antigen Presentation;Antigen Targeting;Antigens;Biology;Brain;Brain Neoplasms;cancer cell;CAR T cell therapy;CD19 Antigens;CD19 gene;CD276 gene;CD47-SIRPα;cell killing;Cell surface;cell type;Cells;Cellular Structures;Childhood;Childhood Glioma;chimeric antigen receptor;Conserved Sequence;Development;Diffuse intrinsic pontine glioma;diffuse midline glioma;effective therapy;Effector Cell;Engineering;Equilibrium;Excision;Exclusion;exhaustion;Extravasation;Glioblastoma;Human;human induced pluripotent stem cells;Immune;immune activation;Immune system;immunosuppressive macrophages;Immunotherapy;improved;in vivo;Infiltration;Inflammatory;interest;ITAM;Lesion;Macrophage;Malignant neoplasm of brain;Malignant Neoplasms;Memory;Microglia;Modeling;Molecular;Monoclonal Antibodies;monocyte;mouse model;Mus;neoplastic cell;Pathway interactions;Patients;Pediatric Neoplasm;Penetration;Peripheral Blood Mononuclear Cell;Phagocytes;Phagocytosis;phagocytosis receptor;Play;Prognosis;Property;Publications;Publishing;receptor;Recruitment Activity;Role;Series;Shapes;Signal Transduction;Solid Neoplasm;System;T-Lymphocyte;Testing;Therapeutic;trafficking;tumor;Tumor Antigens;Tumor Burden;tumor microenvironment;tumor-immune system interactions;Work;Xenograft Model

PROJECT_TITLE: Development of Chimeric Antigen Receptor Phagocytes Against Glioblastoma

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Dental, Oral, and Craniofacial Disease;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE While oral diseases are extremely common and can meaningfully reduce quality of life, relatively few studies have examined the causes of oral diseases during young adulthood, a time when many individuals experience a transition in their economic and social circumstances that can lead to changes in their behaviors and their risk of disease. This study will collect detailed information about economic status, social environments, and health behaviors, as well as general health and oral health, among a diverse population of college students, many of whom are from disadvantaged backgrounds. Such information will increase our understanding of the early stages of long-term oral diseases, including diseases that can lead to future problems like tooth loss, in order to help develop programs and policies that can eventually improve oral health for everyone.

PI_NAMEs: CHAFFEE, BENJAMIN W (contact)

PROGRAM_OFFICER_NAME: IIDA, HIROKO

PROJECT_TERMS: Adolescence;Adult;Age;Attention;Behavior;Behavioral;Blood Pressure;Body mass index;Cardiometabolic Disease;cardiometabolism;Cardiovascular Diseases;Child;Childhood;Chronic;Chronic Disease;cohort;Cohort Studies;Complex;Data;Dental caries;Dental Hygiene;design;Development;Diet;disadvantaged background;Disease;disorder prevention;disorder risk;Economics;Education;effective intervention;emerging adult;emerging adulthood;Employment;ethnic identity;Ethnic Origin;experience;Financial Hardship;First Generation College Students;Future;Gender;Gender Identity;Gingiva;Grant;Health;Health behavior;health equity;health inequalities;Health Promotion;health service use;Health Status;higher education;Hispanic-serving Institution;improved;Incidence;Income;Individual;Inflammation;insight;Intervention;Life;Life Cycle Stages;Link;Liquid substance;Measures;Mediation;Minority;Mouth Diseases;National Heart, Lung, and Blood Institute;novel;older adult;Oral;Oral health;Outcome;Pathway interactions;Patient Self-Report;Periodontal Diseases;Persons;Policies;Population;Population Heterogeneity;prevent;Prevention;programs;prospective;protective factors;Quality of life;Race;racial difference;racial identity;Research;Risk;Risk Factors;Role;Services;Sleep;social;social capital;Social Environment;Social status;Socioeconomic Factors;Socioeconomic Status;socioeconomics;Stress;stressor;substance use;Testing;Time;Tobacco;Tooth Loss;transition to adulthood;university student;young adult

PROJECT_TITLE: Economic Stressors and Opportunities as Influences of Emerging Adult Oral Health

STUDY_SECTION_NAME: Special Emphasis Panel[ZDE1 YM (12)]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

ORG_CITY: SALT LAKE CITY

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Project narrative The objective of this project is to prepare Dr. Ian Boys to transition to an independent position as a tenure-track investigator. This project focuses on 1) using structural homology screens to identify and classify antiviral proteins in biodiverse genomes, as well as anti-immune genes in diverse viruses, and 2) the study of protein families that have diverged to serve distinct functions, with some of them evolving to become antiviral proteins. This multidisciplinary evolution-driven study of the biology of infection presents an opportunity to study functional convergence, with implications for our understanding of how proteins evolve to acquire novel function.

PI_NAMEs: BOYS, IAN  (contact)

PROGRAM_OFFICER_NAME: STOKES, KALYNDA K

PROJECT_TERMS: Advisory Committees;Animals;arms race;BCL2 gene;Biochemical;Biochemistry;bioinformatics tool;Biology;boys;career;Carrier Proteins;Categories;Chimeric Proteins;Classification;combat;Communicable Diseases;comparative;Comparative Study;Computational Biology;Development;Distant;Evolution;experience;experimental study;flexibility;Foundations;functional plasticity;Future;Genes;genetic approach;Genome;Genomics;Goals;Herpesviridae;Homologous Gene;Homologous Protein;host-pathogen coevolution;Immune;Immune system;Immunity;Immunologic Stimulation;Immunology;Infection;Inflammasome;inhibitor;innovation;insight;Learning;Life;Link;Mammals;marenostrin;Mentors;model organism;Modeling;Molecular Biology;Molecular Virology;multidisciplinary;Natural Selections;novel;Organism;pathogen;Pathway interactions;Pattern;Phosphotransferases;Positioning Attribute;Poxviridae;predictive tools;pressure;programs;Property;Protein Family;protein function;protein kinase R;Proteins;Proteome;receptor;Recurrence;Research;Research Personnel;RNA Binding;Role;skills;Source;Structural Models;Structure;System;Techniques;tenure track;Tertiary Protein Structure;tool;Training;Translational Repression;Vaccinia;Vertebrates;Viral;Viral Physiology;Viral Proteins;virology;Virus;Virus Diseases;virus host interaction;Virus Inhibitors;yeast genetics;Yeasts;Zinc Fingers;zygote

PROJECT_TITLE: Functional Convergence at the Host-Virus Interface

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 TWD-A (KR)]


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Networking and Information Technology R&D (NITRD);Opioid Misuse and Addiction;Opioids;Prevention;Social Determinants of Health;Substance Misuse;Telehealth

ORG_CITY: ROCHESTER

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF ROCHESTER

ORG_STATE: NY

PHR: Perceived social isolation—also known as loneliness—has a significant impact on mental and physical health, increasing risk of death. Individuals (N = 300) with an opioid use disorder reporting perceived social isolation will be randomized to either (1) therapist-delivered Cognitive-Behavioral Therapy for Perceived Social Isolation, (2) therapist-delivered Health Education, or (3) self-guided Health Education. We will assess perceived social isolation, opioid and other substance use, the amount and quality of social interactions, and mental health prior to and up to 6 months following the interventions to see how well the they work compared to each other.

PI_NAMEs: ASHRAFIOUN, LISHAM  (contact);STECKER, TRACY A

PROGRAM_OFFICER_NAME: WEBB, CANDACE KARONDELETTE

PROJECT_TERMS: addiction;Address;Aftercare;Behavior;Belief;Cessation of life;Clinical;Cognitive;Cognitive Therapy;Communities;cost effective intervention;craving;Data;Diagnostic;Diagnostic Factor;effective intervention;efficacy testing;efficacy trial;Evidence based intervention;Feedback;follow-up;Goals;health care settings;Health education;Health Services;Individual;innovation;insight;Insurance Carriers;interest;Intervention;intervention effect;Loneliness;Mediating;Medicaid;Medicare;Mental Health;Morbidity - disease rate;mortality;mortality risk;National Institute of Drug Abuse;negative affect;new therapeutic target;novel;Opioid;opioid mortality;opioid use;opioid use disorder;Outcome;Overdose;Participant;Persons;physical conditioning;Pilot Projects;Population;post intervention;premature;Prevention;psychosocial;psychosocial stressors;Public Health;Randomized;Recovery;Recovery Support;recruit;Relapse;Reporting;Research;Risk;Risk Factors;Sampling;Severities;social;social contact;Social Controls;social engagement;social health determinants;Social Interaction;Social isolation;Social support;Strategic Planning;substance use;Substance Use Disorder;Suicide;Symptoms;telehealth;Testing;Therapeutic;therapeutic target;treatment comparison;treatment strategy;Work

PROJECT_TITLE: Addressing perceived social isolation as a novel therapeutic target among individuals with OUD using telehealth CBT

STUDY_SECTION: SPIP

STUDY_SECTION_NAME: Social Psychology, Personality and Interpersonal Processes Study Section[SPIP]


NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: PORTLAND

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE This project aims to develop novel molecular tools to study protein-protein interactors of epigenetic factors. We intend to develop a suite of techniques, that employ specialized antibody barcoding or peptide mass spectrometry to identify protein complexes. Through these methodologies, we will dissect core mechanisms regulating dynamic chromatin alterations at regulatory genomic elements

PI_NAMEs: MOHAMMED, HISHAM  (contact)

PROGRAM_OFFICER_NAME: MASKERI, BAISHALI

PROJECT_TERMS: Antibodies;Bar Codes;Bypass;Cell Differentiation process;Cells;Chromatin;Complement;Complex;Cues;Disease;Disease Progression;DNA;DNA Methylation;Elements;Embryonic Development;Enhancers;Epigenetic Process;Gene Expression;Gene Expression Regulation;Genetic Transcription;Genomics;Homeostasis;Immunoprecipitation;Individual;innovation;instrument;Mass Spectrum Analysis;member;Metabolic;Methodology;Methods;Molecular;multiple omics;Nerve Degeneration;novel;Oligonucleotides;Pattern;Peptides;protein complex;Proteins;Proteomics;Regulatory Element;Reproducibility;response;Sampling;Shapes;Signal Transduction;Signaling Protein;Specificity;Techniques;Technology;Tissues;tool;tool development;transcription factor

PROJECT_TITLE: Deciphering Transcription Factor-Coregulator Interactions through Innovative Tools

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MBBC-F (55)]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Building Research Capacity at Institutions with Limited NIH Funding;Emerging Infectious Diseases;Infectious Diseases;Orphan Drug;Rare Diseases;Tuberculosis

ORG_DEPT: CHEMISTRY

ORG_NAME: SAN FRANCISCO STATE UNIVERSITY

PHR: PROJECT NARRATIVE Antibiotic resistance is currently a major public healthcare concern. Two notoriously hard to kill bacterial, Clostridioides difficile (C. diff) and Mycobacterium tuberculosis (M. tb), have emerging strains that are resistant to many antibiotic treatments and require new drugs that target alternate biosynthetic pathways, such as DNA biosynthesis. Since M. tb and C. diff use an alternate enzyme, (Flavin-Dependent Thymidylate Synthase—FDTS) not present in humans, to synthesize the essential DNA base, thymine, this presents an enticing new direction to target and inhibit these enzymes providing a pathway towards new antimicrobial agents.

PI_NAMEs: KOEHN, ERIC MICHAEL (contact)

PROGRAM_OFFICER_NAME: PEI, WUHONG

PROJECT_TERMS: Active Sites;Anabolism;analog;anti-microbial drug;antibiotic design;Antibiotic Resistance;antibiotic resistant infections;Antibiotic Therapy;Antibiotics;antimicrobial;Antimycobacterial Agents;Bacteria;Bacterial Antibiotic Resistance;Bacterial Infections;base;Binding;Biochemical;Biological Assay;Biophysics;Catalysis;Cessation of life;Chemicals;Clostridium difficile;Code;cofactor;Consensus;Crystallography;design;Development;Disease;DNA;DNA biosynthesis;Docking;Drug Design;drug discovery;Drug Screening;Drug Targeting;efficacy testing;Elements;Enzyme Inhibition;enzyme structure;Enzymes;Eukaryota;experimental study;Flavins;Folic Acid;Future;Genes;Goals;Healthcare;Human;human DNA;human pathogen;infancy;Infection;inhibitor;Interruption;Investigation;Kinetics;Laboratories;Ligand Binding;Literature;Measures;Methodology;Methods;Modeling;Molecular;Mycobacterium tuberculosis;Naphthoquinones;Nature;new therapeutic target;novel;pathogen;pathogenic bacteria;Pathogenicity;Pathway interactions;Pharmaceutical Preparations;Prevalence;Production;protein structure;Proteins;Public Health;Pyrimidine Nucleotides;Quinones;Raltitrexed;rational design;Reaction;Reporting;Research;resistant strain;Role;screening;Structure;Structure-Activity Relationship;success;targeted agent;Techniques;Testing;Therapeutic;Thermodynamics;thermophilic bacteria;thymidylate;Thymidylate Synthase;Thymidylate Synthase Inhibitor;Thymine;tool;Toxic effect;Tuberculosis;TYMS gene;United States;uridylate;virtual

PROJECT_TITLE: Investigation of the Flavin Dependent Thymidylate Synthase enzyme as a potential antimicrobial target

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 RCB-7 (SF)]


ADMINISTERING_IC: AR

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Aging;Arthritis;Clinical Research;Nutrition;Obesity;Osteoarthritis;Physical Activity;Physical Injury - Accidents and Adverse Effects;Physical Rehabilitation;Rehabilitation;Sarcopenia;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_DEPT: OTHER HEALTH PROFESSIONS

PHR: PROJECT NARRATIVE Anterior cruciate ligament injury promotes chronic skeletal muscle weakness and leads to early diagnosis of osteoarthritis. This project seeks to investigate physiologic contributors to skeletal muscle weakness, such as intramuscular adipose tissue, and how it is influenced with age. This will promote impairment-based treatments and rehabilitation to restore skeletal muscle function following injury.

PI_NAMEs: BODKIN, STEPHAN G (contact)

PROGRAM_OFFICER_NAME: WASHABAUGH, CHARLES H

PROJECT_TERMS: Acute;Adipocytes;Adipose tissue;Adult;Age;age difference;age effect;age related changes;age-related muscle loss;aged;Aging;aging mechanism;anterior cruciate ligament injury;anterior cruciate ligament reconstruction;Area;Athletic;base;Biological;Biology;Biometry;Biopsy;career;career development;Cartilage;cartilage degradation;cell type;Chronic;Clinical;clinical decision-making;clinical imaging;Clinical Trials;cohort;college;Conduct Clinical Trials;cytokine;Data;Degenerative polyarthritis;design;Development;Diagnosis;Diet;Disease;Early Diagnosis;Etiology;experience;Extensor;Faculty;Fibrosis;Funding;Goals;Growth;Health;Impairment;improved;Individual;Infiltration;Inflammatory;Injury;Intervention;Intramuscular;Investigation;joint injury;Knee;Knee Injuries;Knowledge;Leadership;life span;limb injury;Linear Regressions;Lipids;Magnetic Resonance Imaging;Measures;Medicine;member;Mentored Research Scientist Development Award;Mentors;Mentorship;middle age;Modeling;Molecular;Muscle;Muscle Development;Muscle function;muscle strength;Muscle Weakness;Muscular Atrophy;Musculoskeletal;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;Neurologist;Obesity;Operative Surgical Procedures;Orthopedic Surgery;Outcome;patient-level barriers;Patients;personalized health care;Physical activity;Physical Rehabilitation;Physical therapy;Physiological;Population;post-operative rehabilitation;prevent;primary outcome;professor;progenitor;Property;quadriceps muscle;Recovery;recruit;reduced muscle strength;Rehabilitation Outcome;Rehabilitation therapy;Research;Research Personnel;Research Priority;Risk;Risk Factors;rotator cuff injury;sarcopenia;sex;Skeletal Muscle;skeletal muscle wasting;skeletal muscle weakness;skills;Source;Sports Medicine;stem cell function;Strategic Planning;strength training;Techniques;Testing;Time;Tissues;Torque;Training;translational scientist;Traumatic Arthropathy;Traumatic injury;Treatment Cost;United States National Institutes of Health;Universities;Utah;vastus lateralis;Work;young adult

PROJECT_TITLE: Skeletal Muscle Remodeling and Intramuscular Adipose Tissue following Traumatic Knee Injury

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: SEATTLE

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative Life must ultimately balance chromosome compaction and accessibility to proliferate, but how organisms mediate this dynamic challenge is poorly understood. Our discoveries of a bacterial chromosome packing regulator and proteins in bacterial viruses that hijack this and other regulators, have pinpointed the mechanisms that bacteria and viruses utilize to regulate DNA packaging. By studying these mechanisms, our long-term goal is to identify new targets and facilitate development of new antibacterial therapies.

PI_NAMEs: GUO, MONICA S. (contact)

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TITLE: Investigating regulators of bacterial chromosome organization

STUDY_SECTION: MRAF

STUDY_SECTION_NAME: Maximizing Investigators' Research Award - F Study Section[MRAF]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding

ORG_CITY: LAS VEGAS

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF NEVADA LAS VEGAS

ORG_STATE: NV

PHR: Project narrative: IPMK is a novel PI3K that is necessary and sufficient for mTORC2 activation in specific cellular compartments, maintaining actin cytoskeletal dynamics and cell migration. Aberrant mTORC2 activation and cell migration are linked to various diseases. Understanding the mechanism of IPMK-mediated mTORC2 activation and cell migration will be useful in understanding disease mechanisms and fundamental cell biological processes.

PI_NAMEs: GUHA, PRASUN  (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TERMS: Actins;Address;Affect;Amino Acids;Binding;Biochemical;Biological;Biological Assay;Biological Process;Carcinoid Tumor;Cell Compartmentation;Cell membrane;cell motility;Cell Nucleus;Cell Physiology;Cell Proliferation;Cells;Clinical;complement C2a;Complex;Crohn's disease;Cytoskeleton;Data;Disease;Elements;Embryo;Endosomes;experimental study;Family;Genetic;Growth Factor;Homeostasis;Human;Immunoprecipitation;Impairment;In Vitro;in vivo;inositol polyphosphate multikinase;insight;Intestines;Investigation;Link;Lipids;live cell imaging;Mass Spectrum Analysis;Mediating;member;Membrane;Methods;Microscopic;Mitochondria;Molecular;Multiprotein Complexes;Mus;mutant;Mutate;novel;Pathologic;Pathway interactions;PDPK1 gene;phosphatidylinositol 3,4,5-triphosphate;Phosphatidylinositol 4,5-Diphosphate;Phosphatidylinositols;Phosphorylation;Phosphorylation Site;Phosphotransferases;Physiological;PIK3CG gene;polymerization;Polymers;Production;Protein Kinase;Proto-Oncogene Proteins c-akt;Publications;Regulation;Research;Role;Second Messenger Systems;Serine;Signal Pathway;Signal Transduction;Threonine;tissue regeneration;Tissues;wound

PROJECT_TITLE: IPMK is a novel PI3k essential for mTORC2 activation and cell migration


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Agent Orange & Dioxin;Chronic Obstructive Pulmonary Disease;Climate-Related Exposures and Conditions;Clinical Research;Endocrine Disruptors;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Effects of Indoor Air Pollution;Lung;Social Determinants of Health

ORG_CITY: RALEIGH

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: NORTH CAROLINA STATE UNIVERSITY RALEIGH

ORG_STATE: NC

PHR: This time-sensitive research study characterizes changes in airborne particulate matter (PM) and its constituents and local population exposure in the aftermath of a policy change to cease open-burn/open-detonation (OBOD) activities at a thermal treatment site that primarily handles munitions wastes in Colfax, LA. Through our work, we will compare concentrations of ambient PM and associated chemicals and their presence in household dust and biological samples at key time periods during OBOD, during site demolition and construction of the closed- burn containment system (CBCS), and at the start of operation of the CBCS in Colfax. We are committed to community engagement best practices including co-production of our study design and frequent report back to community partners to allow for ongoing feedback and input.

PI_NAMEs: RICHMOND-BRYANT, JENNIFER  (contact)

PROGRAM_OFFICER_NAME: HENRY, HEATHER F

PROJECT_TERMS: Afghanistan;Air;air monitoring;Air Pollution;Airborne Particulate Matter;Area;Aromatic Polycyclic Hydrocarbons;Asthma;Back;base;Biological;Biological Warfare;Black race;burn pit;Cardiovascular Diseases;Cardiovascular system;Cessation of life;chemical association;Chemicals;Chronic;Chronic Bronchitis;Chronic Obstructive Pulmonary Disease;coarse particles;Communities;community engagement;community living;community partners;Containment;Coronary Arteriosclerosis;Data;Data Set;Dioxins;Dust;Effectiveness;Environment;Exposure to;Fatigue;Feedback;fine particles;Free Radicals;Furans;Grant;Hazardous Waste;Health;health data;Hearing;Heavy Metals;Home;House Dust;Income;Individual;Iraq;Liver;longitudinal analysis;Louisiana;Malignant Neoplasms;Measures;Metals;Military Personnel;Monitor;Mood Disorders;mortality;Musculoskeletal Diseases;Myocardial Infarction;Nail plate;operation;Oxidative Stress;Paint;Particulate Matter;Perchlorates;Pesticides;Phase;Policies;Poly-fluoroalkyl substances;Population;Positioning Attribute;Production;programs;Pulmonary Emphysema;Refuse Disposal;Reporting;Research;Research Design;research study;respiratory;Respiratory Disease;Risk;Risk Assessment;Rural Community;Sampling;Science;Site;Skin;skin disorder;Soil;Soldier;Solvents;Structure of nail of toe;Superfund;superfund site;System;Technology;technology platform;Thyroid Diseases;Time;Transition Elements;treatment site;ultrafine particle;United States;Universities;Urine;War;Waste Management;wasting;Withholding Treatment;Work

PROJECT_TITLE: Changes in Exposures to PFAS, Metals, Dioxins, and Furans following Cessation of Open Burning of Munitions Wastes at a Hazardous Waste Thermal Treatment Facility

STUDY_SECTION_NAME: Special Emphasis Panel[ZES1 LWJ-K (TS)]


ADMINISTERING_IC: OD

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: DAVIS

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Aging is the single most important risk factor for Alzheimer’s Disease AD, yet the transition from synaptic and cellular alterations that occur with aging and lead to cognitive decline to the pathology of AD is not well understood. We have now developed rhesus macaque models of AD, but it has become very clear that in order to fully exploit these models we need to have a comprehensive understanding of the nature and extent of AD- like pathology in normal aging with no experimental manipulation to create an AD model. We will employ the NIA-supported geriatric colony at the California national Priumate Research Center to begin to characterize this interface and potential basis for a transition to AD.

PI_NAMEs: ATKINSON, SIMON J. (contact)

PROGRAM_OFFICER_NAME: BUHRING, BETTINA D

PROJECT_TERMS: 3-Dimensional;abeta oligomer;Affect;Age;age related;aged;Aging;aging brain;Alzheimer like pathology;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease risk;American;Amyloid;Amyloid beta-Protein;Animal Model;animal old age;Animals;Antibodies;Area;automated segmentation;Autopsy;Behavioral;biobank;Biochemical;Biological Markers;biomarker identification;Brain;Brain-Derived Neurotrophic Factor;California;candidate identification;candidate marker;Cause of Death;Clinical;Cognitive aging;cohort;Collection;Data;Dementia;Development;Disease Progression;Effectiveness;Elderly;Engineering;Epitopes;Experimental Models;Glial Fibrillary Acidic Protein;Health;Human;human old age (65+);hyperphosphorylated tau;Immunoassay;Immunohistochemistry;Immunotherapy;Impaired cognition;improved;in vivo;Individual;Intervention;life span;Light;Liquid substance;Macaca;Macaca mulatta;Medicine;Methods;middle age;Modeling;Monitor;Morphology;Nature;Nerve Degeneration;neurochemistry;Neurodegenerative Disorders;neurofilament;neuroinflammation;neuropathology;nonhuman primate;normal aging;parent project;Pathogenesis;Pathologic;Pathology;Pattern;Phylogenetic Analysis;Plasma;Prefrontal Cortex;Primates;Process;protein aggregation;Public Health;Research;Research Personnel;Role;Sampling;Senile Plaques;sex;Synapses;tau Proteins;Testing;tool;TREM2 gene;United States National Academy of Sciences;United States National Institutes of Health

PROJECT_TITLE: Alzheimer's Disease Pathology and Biomarkers in a Cohort of Aged Rhesus Macaques

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(41)-P]


ADMINISTERING_IC: VA

FUNDING_MECHANISM: OTHERS

IC_NAME: Veterans Affairs

ORG_NAME: VA SALT LAKE CITY HEALTHCARE SYSTEM

PHR: The proposed research is relevant to Veteran health because it focuses on defining the sites (peripheral vascular, mitochondrial, and neuromuscular systems) and underlying mechanisms (elevated ROS) contributing to the exercise intolerance induced by stage I-III breast cancer (Phase A) and cytotoxic and endocrine therapies (Phase B). These results are expected to have an important positive impact because they will provide information that is fundamental for developing targeted therapies to mitigate the systemic effects of breast cancer and cytotoxic and endocrine therapies, thereby preserving quality of life. Thus, the proposed research is relevant to the Women Veteran’s health priority research of CSR&D and the VA National Cancer Strategy objective to improve quality of life of patients.

PI_NAMEs: BROXTERMAN, RYAN MICHAEL (contact)

PROJECT_TERMS: Affect;anti-cancer research;Antioxidants;Area;Attenuated;Biological Availability;Blood flow;Blood Vessels;breast cancer diagnosis;Breast Cancer therapy;cancer cell;cancer therapy;career;career development;Clinical Trials;comparison control;Complex;Cytotoxic Chemotherapy;Data;Development;Diagnosis;Disease;evidence base;Exercise;exercise intolerance;Exercise Tolerance;Exhibits;Extensor;Fatigue;Functional disorder;Health;Health Priorities;Healthcare;hormone therapy;Impairment;improved;innovation;Intervention;Knee;Leg;Lipids;Malignant Breast Neoplasm;Malignant Neoplasms;Mediating;Metabolic;Mitochondria;mitoquinone;Movement;Muscle;Muscle Fibers;Muscle Mitochondria;neuromuscular;neuromuscular function;neuromuscular system;Nitric Oxide;Nitrogen;Operative Surgical Procedures;Oxygen;Patients;Peripheral;Peripheral Nerve Stimulation;Permeability;Phase;Physical Function;preservation;prevent;Probability;Proteins;Quality of life;Reaction;Research;Research Priority;Respiration;response;Role;Severities;Site;Skeletal Muscle;System;targeted treatment;therapeutic target;therapy development;Training;Veterans;Woman

PROJECT_TITLE: Mechanisms of systemic dysfunction responsible for exercise intolerance induced by breast cancer, cytotoxic chemotherapy, and endocrine therapy in Veterans


ADMINISTERING_IC: HL

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Genetics;Infectious Diseases;Lung

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE As respiratory infections result in millions of deaths annually, these pulmonary diseases are considered as the global leading cause of communicable mortality. As such, human health greatly benefits from studies that address the regulatory mechanisms of immune development and function in the lungs. This research proposal aims to investigate the regulatory contributions of chromatin remodeling during the development, maintenance, and immune response of alveolar macrophages to respiratory infections.

PI_NAMEs: RATTU MANDIAS, HANNAH CAROLINE (contact)

PROGRAM_OFFICER_NAME: ESPINOZA-PINTUCCI, MARISOL

PROJECT_TERMS: adaptive immunity;Address;Adoptive Transfer;Affect;Alveolar;Alveolar Macrophages;Anti-Inflammatory Agents;Apoptotic;Asthma;ATAC-seq;Binding;Biological Assay;Blood-Air Barrier;Bone Marrow;Cause of Death;Cells;Cessation of life;Chimera organism;Chromatin;chromatin remodeling;Chromatin Remodeling Factor;Chronic Obstructive Pulmonary Disease;Cleavage Under Targets and Release Using Nuclease;cofactor;Communication;Complex;Cues;cytokine;Data;Development;Disease;DNA;DNA Methylation;Elderly;Environment;Epigenetic Process;epigenetic therapy;Epithelium;Exhibits;Family;fetal;Functional disorder;Future;Gene Expression;Gene Expression Profile;Generations;Genetic;Genetic Transcription;Goals;Granulocyte-Macrophage Colony-Stimulating Factor;Health;Hematopoietic;Homeostasis;Host Defense;Human;Immune;immune function;Immune response;Immune system;Immune Tolerance;Immunity;Immunocompromised Host;improved;in vivo;Individual;Inflammatory;Inflammatory Response;Influenza;influenza infection;intercellular communication;Knock-out;Longitudinal Studies;Lung;Lung Diseases;Lung infections;Macrophage;Maintenance;Malignant neoplasm of lung;Malignant Neoplasms;Measures;Microbe;Mission;Modeling;Modification;Molecular;monocyte;Mononuclear;Morbidity - disease rate;mortality;mouse model;Mus;Myelogenous;novel;pathogen;Pathway interactions;Phagocytes;Phagocytosis;Phenotype;Physiological;Play;Pneumonia;Population;PPAR gamma;prevent;Process;programs;Property;Pulmonary alveolar structure;pulmonary function;recruit;Research;Research Proposals;Respiratory Tract Infections;response;Role;self-renewal;Sentinel;Signal Transduction;Signaling Molecule;Stimulus;Stress;Structure of parenchyma of lung;surfactant;T-Cell Activation;T-Lymphocyte;targeted treatment;tissue repair;Tissues;Toxin;transcription factor;transcriptome sequencing;Transforming Growth Factor beta;United States National Institutes of Health;Variant;Viral;Virus Diseases

PROJECT_TITLE: The Involvement of PBRM1 in Alveolar Macrophage Development, Homeostasis, and Immune Function


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Digestive Diseases;Hematology;Inflammatory Bowel Disease

ORG_DEPT: PATHOLOGY

PHR: Project Narrative Inflammatory bowel disease (IBD) is a lifelong chronic condition characterized by platelet hyperactivity and significantly increased risk of thromboembolic disease, the most significant cause of mortality in IBD. Our preliminary research has identified the hyaluronan receptor layilin as a regulator of platelet activation that links inflammation and thrombosis in IBD. Since there are no cures available for IBD, the research proposed in relevant to public health and the proposed studies investigate innate immune mechanisms that are important to the onset and progression of disease which is relevant to the NHLBI’s mission.

PI_NAMEs: MELLEMA, REBECCA  (contact)

PROGRAM_OFFICER_NAME: WARREN, RONALD Q

PROJECT_TERMS: Adhesions;Affect;Antibodies;Automobile Driving;Binding;Biological Assay;Blood Platelets;Cause of Death;CD44 Antigens;CD44 gene;cell type;Cells;Characteristics;Chronic;chronic inflammatory disease;Circulation;Colitis;Colon;cytokine;Data;Disease;Disease Progression;Drug Targeting;Enzymes;Extracellular Matrix;F2R gene;Flow Cytometry;Foundations;Functional disorder;Gastrointestinal tract structure;General Population;Glycosaminoglycans;Goals;Human;Hyaluronan;Hyaluronidase;Hyperactivity;Immune;immune cell infiltrate;Immunosuppressive Agents;Impairment;In Vitro;in vivo;Incidence;Inflammation;Inflammatory;Inflammatory Bowel Diseases;innate immune mechanisms;Innate Immune Response;innovation;insight;Intestines;Knockout Mice;leukocyte activation;Leukocytes;Link;Measures;Mediating;Megakaryocytes;Metabolism;Mission;Molecular;mortality;mouse model;murine colitis;Mus;National Heart, Lung, and Blood Institute;new therapeutic target;novel;novel therapeutics;Operative Surgical Procedures;Outcome;Pathogenesis;Pathway interactions;Patients;Platelet Activation;Platelet aggregation;platelet function;Play;prevent;Public Health;receptor;receptor binding;Receptor Inhibition;recruit;Research;Risk;Role;Signal Transduction;Site;Structure;Submucosa;Surface;Symptoms;Testing;Thromboembolism;thromboinflammation;Thrombosis;Tissues;Ulcerative Colitis;Work

PROJECT_TITLE: Layilin as a modulator of platelet activation and thromboinflammation


ORG_CITY: St. Louis

ORG_NAME: ST. LOUIS VA MEDICAL CENTER

ORG_STATE: MO

PHR: Our observation that microglia, key innate immune cells of the central nervous system, are found circulating with cerebrospinal fluid of patients with multiple sclerosis (MS) and amyotrophic lateral sclerosis (ALS), has led us to hypothesize that these cells are phenotypically unique in different diseases. We will examine patients with MS and ALS to determine any disease-specific features of CSF microglia and explore the nature of these cells in rat models of MS and ALS.

PI_NAMEs: WU, GREGORY  (contact)

PROJECT_TERMS: Address;Amyotrophic Lateral Sclerosis;Animal Model;Biological Assay;Biopsy;Bone Marrow;Cell Physiology;Cell Separation;Cells;Central Nervous System;Central Nervous System Diseases;Cerebrospinal Fluid;cerebrospinal fluid flow;Characteristics;Chimera organism;Dendritic Cells;differential expression;Disease;efficacious treatment;Elements;Exhibits;Exposure to;Flow Cytometry;Functional disorder;Gene Expression;Gene Expression Profile;Gene Expression Profiling;Growth;Health;Human;Immune;Immunity;Immunologic Markers;Immunologics;Individual;Inflammation;Informatics;insight;Investigation;Membrane Proteins;Microglia;Modeling;Molecular;Molecular Profiling;monocyte;Multiple Sclerosis;multiple sclerosis patient;Mutation;Myelogenous;Myeloid Cells;Nature;Nerve Degeneration;Nervous System Disorder;Neurodegenerative Disorders;neuroinflammation;Neurology;neuropathology;new therapeutic target;next generation;next generation sequencing;novel;Pathogenesis;patient stratification;Patients;Phenotype;Population;Primary Progressive Multiple Sclerosis;Process;prognostic;Property;prospective;protein expression;Radiation;Rattus;Resolution;Role;Sampling Studies;single-cell RNA sequencing;Source;superoxide dismutase 1;Techniques;therapeutic development;Tissues;Traction;trait;transcriptome sequencing;transcriptomic profiling;transcriptomics;Yolk Sac

PROJECT_TITLE: Role of CSF microglia in health and disease


ORG_CITY: BOSTON

ORG_NAME: VA BOSTON HEALTH CARE SYSTEM

ORG_STATE: MA

PHR: Cognitive Processing Therapy (CPT), the evidence-based psychotherapy for PTSD most frequently delivered within VHA, yields large magnitude reductions in primary PTSD outcomes. Corresponding gains in occupational, social, leisure, and sexual functioning, and in health-related concerns, including chronic pain have also been demonstrated. Despite CPT’s effectiveness, there is room for improvement in overall outcomes (about 2/3 retain their PTSD diagnosis) and patient engagement (35-40% drop out prior to treatment completion). Further, improvements in functioning and quality of life are more modest than those observed in PTSD and associated mental health symptoms. Unaddressed difficulties in functioning contribute to premature dropout from EBPs for PTSD among Veterans. Directly targeting impairments associated with psychosocial functioning has the potential to substantially increase the scope of recovery beyond the core symptoms of PTSD and facilitate greater patient engagement, resulting in more Veterans benefitting from CPT.

PI_NAMEs: GALOVSKI, TARA E (contact);KEHLE-FORBES, SHANNON M.

PROJECT_TERMS: Address;Aftercare;Anger;Anxiety;Area;associated symptom;Certification;Chronic;chronic pain;Client;Clinic;Clinical;Cognitive;cognitive benefits;cognitive enhancement;Cognitive Therapy;comorbidity;Complex;Data;Data Sources;depressive symptoms;Diagnosis;Diagnostic;diaries;Disease;Dose;Dropout;Drops;effective therapy;Effectiveness;effectiveness evaluation;evidence base;Exposure to;flexibility;follow-up;Formulation;Freedom;Frequencies;Functional impairment;Goals;Health;Healthcare;Heterogeneity;Impairment;improved;individual patient;individualized medicine;Injury;Intervention;Interview;Leisures;Measures;Mental Depression;Mental Health;Mental Health Associations;Mental Health Services;Methods;military veteran;Modeling;Monitor;novel;Numbness;Occupational;Outcome;Panic;patient engagement;patient population;Patient Self-Report;Patient-Focused Outcomes;Patients;Personal Satisfaction;personalized intervention;Post-Traumatic Stress Disorders;premature;primary outcome;Process;programs;Protocols documentation;Provider;psychologic;psychosocial;psychosocial rehabilitation;Psychotherapy;Publishing;Quality of life;Randomized;Randomized, Controlled Trials;Recommendation;Recovery;Rehabilitation therapy;relative effectiveness;Research;response;Sampling;secondary outcome;Sex Functioning;Sleep;social;standardize measure;substance use;success;suicidal;Suicide prevention;Surveys;Symptoms;Techniques;Trauma;Traumatic Brain Injury;traumatic event;Treatment outcome;treatment responders;Veterans;Veterans Health Administration;Work

PROJECT_TITLE: Personalizing Cognitive Processing Therapy with a Case Formulation Approach to Intentionally Target Impairment in Psychosocial Functioning Associated with PTSD

STUDY_SECTION_NAME: Behavioral Health & Social Reintegration[RRD4]


NIH_SPENDING_CATS: Cardiovascular;Congenital Heart Disease;Genetics;Heart Disease;Orphan Drug;Pediatric;Rare Diseases

ORG_CITY: Nashville

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: Project narrative Loss of function mutations in the voltage gated potassium channel KCNQ1 cause type 1 long QT syndrome (LQT1), a cardiac disorder associated with arrythmias, cardiac arrest, and sudden unexpected death. Previous studies suggest that decreased efficiency of trafficking to the plasma membrane (mistrafficking) may be a common mechanism of KCNQ1 loss of function in LQT1. In the proposed project, I plan to investigate the role of KCNQ1 mistrafficking in LQT1 by classifying the trafficking phenotype of all possible KCNQ1 variants and determine whether KCNQ1 trafficking can be altered with small molecules by performing a high throughput screen for compounds that modify the trafficking of KCNQ1.

PI_NAMEs: MOSTER, KATHERINE R (contact)

PROGRAM_OFFICER_NAME: WEBB, STEPHANIE JOHNSON

PROJECT_TERMS: Action Potentials;Binding;Biological Assay;Cardiac;Cardiac Myocytes;Cell Line;Cell membrane;Cell surface;Cells;Cessation of life;Characteristics;Classification;Color;Cystic Fibrosis;Defect;Disease;DNA;Dose;drug development;Electrocardiogram;Endoplasmic Reticulum;Evaluation;Exhibits;Flow Cytometry;Fluorescence-Activated Cell Sorting;Functional disorder;Genes;Genome;Goals;Heart Arrest;Heart Diseases;high throughput screening;Image;Immunofluorescence Immunologic;Impairment;improved;Individual;Induced Mutation;insight;Lead;Left;Libraries;Long QT Syndrome;loss of function;loss of function mutation;Mammalian Cell;Mediating;Membrane Proteins;Methods;Molecular;Molecular Bank;Molecular Chaperones;mutant;Mutation;mutation screening;next generation sequencing;novel;Pharmaceutical Preparations;pharmacologic;Pharmacotherapy;Phenotype;Population;Potassium;Potassium Channel;Proteins;Research;response;Retinitis Pigmentosa;Rhodopsin;Risk;Role;Romano-Ward Syndrome;Route;Severities;small molecule;Sorting;Specificity;Structure;Surface;Symptoms;Testing;trafficking;treatment choice;Variant;variant of unknown significance;voltage;Voltage-Gated Potassium Channel

PROJECT_TITLE: Investigating KCNQ1 Mistrafficking in Long QT Syndrome


ORG_CITY: PROVIDENCE

ORG_NAME: PROVIDENCE VA  MEDICAL CENTER

ORG_STATE: RI

PHR: PROJECT NARRATIVE / RELEVANCE Improving stroke-related disability and stroke rehabilitation are major priorities for the VA healthcare system. Over 15,000 Veterans suffer from stroke each year in the United States, the majority of whom have resulting arm and hand motor impairments that limit their everyday function. Current treatment options to improve motor function after stroke are limited. Therapies including neurotechnological approaches (i.e. non-invasive brain stimulation and brain computer interfaces) for motor neurorehabilitation have not yet realized their potential to maximize recovery because the precise neuroanatomic and neurophysiologic mechanisms of upper extremity hemiparesis have not been clearly defined. Dr. Lin’s proposed career development plan has outstanding potential to advance knowledge about the neuroscientific mechanisms of upper extremity hemiparesis after stroke, which is a crucial step towards the development and translation of novel neurorehabilitation therapies to maximize functional recovery, improve stroke rehabilitation, and reduce stroke-related disability for Veterans.

PI_NAMEs: LIN, DAVID J (contact)

PROJECT_TERMS: Acoustics;Acute;acute stroke;Anatomy;Area;arm;arm function;Bilateral;Biomechanics;Biometry;brain computer interface;brain pathway;career;career development;Caring;Chronic;chronic stroke;Clinical;Clinical Trials;cohort;Complement;Contralateral;Corticospinal Tracts;Cross-Sectional Studies;Data;Dedications;Development;Development Plans;dexterity;Diffusion Magnetic Resonance Imaging;disability;Distal;Electroencephalography;Environment;experience;Future;General Hospitals;Goals;Hand;Hand functions;Healthcare Systems;hemiparesis;Impairment;improved;Individual;insight;Intervention;Ischemic Stroke;K-Series Research Career Programs;kinematics;Knowledge;Laboratories;Lead;Lesion;Maps;Massachusetts;medical schools;Mentors;Mentorship;Modeling;Motor;motor control;Motor Cortex;motor deficit;motor function improvement;motor impairment;Motor Pathways;motor recovery;multidisciplinary;Natural History;neural;Neuroanatomy;neuroimaging;Neurologic;neurological rehabilitation;Neurologist;Neurology;Neuronal Plasticity;neurophysiology;neurorestoration;Neurosciences;neurotechnology;noninvasive brain stimulation;novel;Pathway interactions;patient oriented research;Pattern;Phenotype;Physicians;Physiologic pulse;Physiology;post stroke;Prospective cohort;randomized, clinical trials;Recovery;Recovery of Function;recruit;Research;Research Project Grants;research study;Resources;response;Science;Scientist;skills;Spinal Cord;Stimulus;Stroke;stroke hemiparesis;stroke patient;stroke recovery;stroke rehabilitation;stroke therapy;Syndrome;synergism;System;targeted treatment;Technology;Testing;Training;Transcranial magnetic stimulation;Translating;Translations;United States;Upper Extremity;Variant;Veterans

PROJECT_TITLE: Deconstructing Post-Stroke Hemiparesis for Precision Neurorehabilitation

STUDY_SECTION_NAME: Career Development Program - Panel I[RRD8]


NIH_SPENDING_CATS: Clinical Research;Genetics;Human Genome;Lung;Pulmonary Hypertension;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project Narrative Pulmonary arterial hypertension (PAH) is a deadly disease of the pulmonary blood vessels that may in part be caused by mutations of a person’s DNA. My proposal aims to establish the role of one such mutation, its regulation of abnormal blood vessel behavior, and its effects on PAH severity. These findings may aid in developing more effective ways to detect and treat this deadly disease.

PI_NAMEs: KIRILLOVA, ANNA  (contact)

PROGRAM_OFFICER_NAME: SUTLIFF, ROY L

PROJECT_TERMS: Alleles;angiogenesis;Angiogenesis Inhibition;Antigen-Presenting Cells;Architecture;ATF6 gene;Behavior;Binding;Biological Assay;Blood Vessels;Cardiovascular system;career;Cell Extracts;cell motility;Cell Physiology;cell type;Cells;Chromatin;chromatin immunoprecipitation;Clinical;clinical translation;cohort;Data;Diagnosis;Diagnostic;diagnostic tool;Disease;Distal;DNA;Endothelial Cells;endothelial dysfunction;Endothelium;Enhancers;Exhibits;experimental study;Exposure to;gain of function;Gene Targeting;Genes;Genetic;Genome;genome wide association study;Genotype;Hematological Disease;Histocompatibility Antigens Class II;Human;Immune;induced pluripotent stem cell;Inflammatory;insight;Link;Linkage Disequilibrium;loss of function;Lung;Lung Diseases;Maps;Mediating;Mediator;migration;mortality;Mutation;novel diagnostics;Nuclear;Nucleotides;Oligonucleotides;Pathogenicity;Pathologic;Patients;Peripheral Blood Mononuclear Cell;Persons;Phenotype;physical model;Physicians;Population;Populations at Risk;Process;prognostic tool;Property;Protein Isoforms;pulmonary arterial hypertension;pulmonary artery endothelial cell;pulmonary vasoconstriction;Regulation;Risk;Role;Scientist;Severities;Severity of illness;Single Nucleotide Polymorphism;SNP genotyping;Specificity;Testing;Therapeutic;Training;transcription factor;Untranslated RNA;Variant;Vascular remodeling;vasoconstriction

PROJECT_TITLE: ACTN4 Binding to Functional SNP rs9277336 Controls the Genome Architecture and Endothelial Pathophenotypes in Pulmonary Arterial


ORG_CITY: LOS ANGELES

ORG_NAME: VA GREATER LOS ANGELES HEALTHCARE SYSTEM

PHR: Vocal folds are the vibrating parts of the human larynx that produce voice. Vocal folds can be damaged from a number of injuries, including surgeries for laryngeal cancer or non-cancerous masses, radiation therapy for other head and neck cancers, smoke or chemical inhalation injuries, and chronic severe acid reflux. Once the vocal folds are scarred, there is little that can be done to restore their vibration. Veterans with vocal fold injuries can suffer disabling voice difficulties with poor voice quality and vocal fatigue. The communication impairment limits social interactions and job opportunities. This project aims to develop an implantable vibrating replacement tissue to restore voice for these Veterans.

PI_NAMEs: LONG, JENNIFER L (contact)

PROJECT_TERMS: 3-Dimensional;Acoustics;Adipose tissue;Adult;Adverse event;Animal Model;Animals;Autopsy;Bilateral;Cell Separation;Cells;Chemicals;Chronic;Cicatrix;Collagen Fiber;Communication impairment;Data;Data Collection;Deposition;Desmosine;Development;Disabling;efficacy testing;Elastic Fiber;Emotional;Excision;experience;Extracellular Matrix;Family suidae;Fatigue;Female;Fibrin;Fibrosis;Frequencies;functional restoration;Gastroesophageal reflux disease;Goals;Head and Neck Cancer;healing;Histologic;Human;Hydrogels;Hydroxyproline;Immunocompetent;Impairment;Implant;implantation;Implantation procedure;improved;in vivo;Inhalation;injured;Injury;Laboratories;Laryngeal Diseases;Larynx;Laser Scanning Microscopy;Link;male;Malignant neoplasm of larynx;Mammals;Measurement;Measures;mechanical behavior;mechanical properties;Mechanics;mesenchymal stromal cell;Methods;Miniature Swine;Modeling;Morphology;multipotent cell;Occupational;Occupations;Operative Surgical Procedures;Oryctolagus cuniculus;Outcome;Periodicals;Phonation;Pilot Projects;Postoperative Period;Proteins;Proteomics;Radiation therapy;Recovery;Regenerative Medicine;repaired;replacement tissue;Research;restoration;Safety;Sampling;scaffold;Serum;Smoke;smoke inhalation;social;Social Interaction;sound;Speed;Structure;Testing;tissue culture;Tissue Engineering;Tissues;Translations;Trauma;Urine;Veterans;vibration;vocal cord;Voice;Voice Disturbances;Voice Quality;Work;wound healing

PROJECT_TITLE: Long-term function of vocal fold replacement in swine

STUDY_SECTION_NAME: Regenerative Rehabilitation[RRD0]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: CHARLESTON

ORG_DEPT: NEUROLOGY

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: PROJECT NARRATIVE Blood-based biomarkers including hyperphosphorylated tau-181 (p-tau181) have emerged as a possible efficient and accurate tool to assist with early detection and disease monitoring for Alzheimer's Disease (AD). However, further validation and understanding of how these biomarkers reflect underlying AD processes and changes in white matter microstructure are necessary. This study will examine the relationships between plasma p-tau181 and the role of early white matter changes in the context of preclinical AD within a longitudinal research cohort with the goal of further validating this biomarker for research and clinical implementation.

PI_NAMEs: BENITEZ, ANDREANA  (contact)

PROGRAM_OFFICER_NAME: ROVESCALLI, ALESSANDRA C

PROJECT_TERMS: Activities of Daily Living;Aging;Alzheimer's Disease;Alzheimer's disease pathology;Amyloid;Biological Markers;biomarker validation;biomedical imaging;Biometry;blood-based biomarker;career;Child Rearing;Clinical;Clinical assessments;clinical care;clinical implementation;clinically relevant;Cognitive;cognitive function;cohort;cost effective;Data;Development;Diagnosis;Diagnostic;diagnostic accuracy;Diffusion;Diffusion Magnetic Resonance Imaging;Disease;Doctor of Philosophy;Early Diagnosis;follow-up;Funding;Gliosis;Goals;Grant;hyperphosphorylated tau;Impaired cognition;improved;indexing;Individual;interest;K-Series Research Career Programs;Language;Longitudinal Studies;Magnetic Resonance Imaging;Measures;Medical;Memory;Mentors;minimally invasive;Modeling;Monitor;Mosses;Myelin;Nature;Nerve Degeneration;neuroimaging;Neurology;neuropathology;Neuropsychological Tests;older adult;parent grant;Participant;Pathologic;Pathology;Peer Review;Performance;performance tests;Plasma;Population;Positron-Emission Tomography;pre-clinical;Principal Investigator;Process;professor;prognostic;prognostic value;Publications;repaired;Research;Research Activity;Research Personnel;Risk;Role;Sampling;Senile Plaques;Signal Transduction;South Carolina;specific biomarkers;Spouses;Structure;symposium;tau-1;Techniques;Threonine;tool;Training;Universities;Validation;Visit;white matter;white matter change;Work

PROJECT_TITLE: Quantitative Neuroimaging Assessment of White Matter Integrity in the Context of Aging and AD

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Data Science;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Networking and Information Technology R&D (NITRD);Prevention;Social Determinants of Health

ORG_CITY: LONDON

ORG_COUNTRY: UNITED KINGDOM

ORG_FIPS: UK

ORG_NAME: UNIVERSITY COLLEGE LONDON

ORG_ZIPCODE: WC1E 6BT

PHR: Title: Advancing Prevention Research In Cancer through Ontology Tools (The APRICOT project) Project Narrative Research into cancer prevention through behavior change, like other areas of behavioral science, is hampered by imprecision and heterogeneity in the use of constructs across studies and data sets, limiting integration and knowledge accumulation. We have developed a large, semantically rich, Behavior Change Intervention Ontology (BCIO) with associated tools and resources that together provide a starting point for developing an innovative solution to this problem. We will engage with a diverse Community of Practice to set up an ongoing and sustainable program to: (i) enhance and extend the BCIO, specifically focusing on the behavioral cancer risk factors of tobacco use and physical (in)activity, and including causal relations between intervention components and mechanisms of action (processes of change), (ii) integrate the BCIO with other ontologies capturing ‘real-world’ data to better address issues relating to the Social and Environmental Determinants of Health (e.g., poverty, educational level, gender identity and sexual orientation, racial and ethnic group, and built environment), and (iii) develop tools and resources to promote effective and widespread adoption of the BCIO for writing study reports and protocols, and evidence synthesis for theory building and intervention development.

PI_NAMEs: MICHIE, SUSAN  (contact)

PROGRAM_OFFICER_NAME: WOLFF-HUGHES, DANA L

PROJECT_TERMS: Acceleration;Address;Adopted;Adoption;annotation  system;Apricot;Area;Behavior;behavior change;Behavior Therapy;Behavioral;behavioral and social science;behavioral outcome;Behavioral Research;Behavioral Sciences;built environment;cancer prevention;cancer risk;Censuses;Characteristics;Clinical;Collaborations;Community of Practice;computer scientist;Data;Data Set;design;Development;Educational Status;Engineering;Ensure;Ethics;Ethnic Population;Evaluation;Evaluation Studies;evidence base;FAIR principles;Fast Healthcare Interoperability Resources;Force of Gravity;Fostering;Funding;Gender Identity;health data;health determinants;Heterogeneity;implementation strategy;implementation tool;improved;innovation;interoperability;Intervention;Investments;Knowledge;Label;Life;Link;Malignant Neoplasms;Maps;Measures;Medical;Medicine;member;Metadata;method development;Methodology;multidisciplinary;NCI Thesaurus;online resource;Ontology;ontology development;Outcome Assessment;Paper;Patients;Pattern;Persons;Physical activity;Policies;Policy Maker;Population;Poverty;prevent;Prevention Research;Process;Production;Program Sustainability;Protocols documentation;Public Health;racial population;Records;Reporting;Research;Research Design;Research Personnel;research study;Resources;Risk Factors;Role;Science;Scientist;Semantics;Services;Sex Orientation;SNOMED Clinical Terms;social;Source;Specific qualifier value;success;Taxonomy;Techniques;theories;therapy development;Tobacco use;tool;Training;Unified Medical Language System;United States National Academy of Sciences;United States National Institutes of Health;usability;Vocabulary;wasting;Work;Writing

PROJECT_TITLE: Accelerating Behavioral and Social Sciences through Ontology Development and Application: NIH Research Network Project (APRICOT).

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 SCIL-D (50)]


NIH_SPENDING_CATS: Genetics

ORG_CITY: CLEVELAND

ORG_DEPT: PHARMACOLOGY

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: NARRATIVE The purpose of the current proposal is to understand the molecular structure and functional interactions of human telomeres. A related goal of this project is designed to identify the molecular changes in telomere proteins that are the result of diverse pathogenic mutations and the associated interference related to nucleotide concentrations and administration of nucleotide/nucleoside analogs. This knowledge is a prerequisite to developing rational drugs for treating human disease related to telomere dysfunction, aberrant DNA damage, and chromosome instability.

PI_NAMEs: TAYLOR, DEREK JAMES (contact)

PROGRAM_OFFICER_NAME: VATAKIS, DIMITRIOS NIKOLAOS

PROJECT_TERMS: Affect;analog;Anti-viral Agents;Area;Binding;Biogenesis;Biological Assay;cancer type;Cell Proliferation;chemotherapy;Chromosomal Instability;chromosome replication;Chromosomes;Collaborations;Collection;Complex;Core Protein;Cryoelectron Microscopy;Data;design;Diagnosis;Discrimination;Disease;DNA;DNA Binding;DNA biosynthesis;DNA Damage;DNA Repair;Ensure;Enzymes;Event;Excision;Exhibits;FDA approved;Functional dependence;Functional disorder;Genes;genetic information;Genome;Genome Stability;Genomic Instability;Goals;Homeostasis;Human;human disease;Impairment;Individual;Investigation;Kinetics;Knowledge;Length;Mediating;Metabolic;Modeling;Molecular;Molecular Structure;Motion;Mutate;Mutation;non-Native;Nucleoproteins;nucleoside analog;Nucleosides;nucleotide analog;Nucleotides;Outcome;Pathogenicity;Pathologic;Pathway interactions;Patients;Pharmaceutical Preparations;pharmacologic;Physiological;Polymerase;prevent;Process;Proteins;Reaction;recruit;Regulation;Research;Resolution;response;RNA;Role;side effect;Signal Transduction Pathway;Single Nucleotide Polymorphism;Single-Stranded DNA;Specificity;standard of care;Structure;Telomerase;telomere;Telomere Maintenance;Telomere-Binding Proteins;Therapeutic;Viral;Virus Diseases;Work

PROJECT_TITLE: Molecular interactions and regulatory events in telomere maintenance

STUDY_SECTION: MSFB

STUDY_SECTION_NAME: Macromolecular Structure and Function B Study Section[MSFB]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Genetics;Huntington's Disease;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: GAINESVILLE

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: The proposed work is relevant to public health because the discovery of molecular mechanisms of ribosome stalling regulation in Huntington disease is ultimately expected to increase understanding of the neuronal vulnerability in diseases such as Parkinson disease, as well as provide framework for developing novel therapeutic strategies, based on mechanisms-based approaches. Thus, the proposed research is relevant to the part of NIH's mission that pertains to acquiring basic insights that will aid to lessen the pain of human of disability.

PI_NAMEs: SUBRAMANIAM, SRINI  (contact)

PROGRAM_OFFICER_NAME: MILLER, DANIEL L

PROJECT_TERMS: 3' Untranslated Regions;Affinity Chromatography;age related;Amino Acids;Binding;Binding Proteins;Biochemical;biochemical tools;Brain;Cells;Cognitive;Complex;Corpus striatum structure;crosslink;Data;Diagnostic;disability;Disease;disease model;Disease Progression;Exhibits;Exons;experimental study;FMR1 gene;Human;Huntington Disease;Huntington gene;Immunoprecipitation;In Vitro;in vivo;insight;Investigation;Knock-in;Mass Spectrum Analysis;Mediating;Messenger RNA;Methods;Mission;Modality;Molecular;Motor;motor deficit;motor symptom;mouse model;Movement;mRNA Translation;Multiple Abnormalities;Mus;Nerve Degeneration;Neurobehavioral Manifestations;Neurologic;Neurons;novel;novel therapeutic intervention;Outcome;Pain;Parkinson Disease;Pathogenesis;Pathogenicity;Play;polyglutamine;polypeptide;polyproline;Polyribosomes;postsynaptic;premature;prevent;Protein Biosynthesis;Protein Synthesis Inhibition;Proteins;Proteome;psychiatric symptom;Public Health;Publishing;Regulation;Reporter;Research;Ribosomal Interaction;Ribosomal Proteins;Ribosomal RNA;ribosome profiling;Ribosomes;RNA;RNA-Binding Proteins;Role;Solid;Synapses;Synaptosomes;Therapeutic;Tissues;tool;translation factor;Translations;ultra high resolution;United States National Institutes of Health;Up-Regulation;Work

PROJECT_TITLE: Mechanisms of Translational Dysregulation in Huntington disease

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Genetics;Human Genome

ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: PROJECT NARRATIVE Chronic diseases such as autoimmune diseases are genetically complex and it is hard to predict whether certain mutations increase disease risk and how they increase disease risk, especially when they are not present in DNA regions that directly code for proteins. In this proposal, we will utilize and develop holistic approaches to systematically investigate how specific regions of the genome affect the long-term gene function in T lymphocytes, a class of cells that are highly relevant in autoimmunity, and to delineate how these regions ensure that T cells remain fit and protect against disease. Once we define the importance of these genomic regions on long-term gene function, and unravel how they alter disease, we will be able to develop appropriate therapeutic strategies to reduce poor disease outcomes.

PI_NAMEs: ISSUREE, PRIYA  (contact)

PROGRAM_OFFICER_NAME: CHOW, CHI-WING

PROJECT_TERMS: Affect;Autoimmune;Autoimmune Diseases;Autoimmunity;B-Lymphocytes;Cell Maturation;Cell Physiology;cell type;Cells;Chromatin Structure;Chronic Disease;Code;Complex;demethylation;Development;Disease;Disease Outcome;disorder risk;DNA;DNA Methylation;Ensure;Epigenetic Process;Exhibits;Foundations;Future;Gene Expression;Gene Expression Regulation;gene function;Genes;Genetic Polymorphism;Genome;genome wide association study;Genomic Segment;Goals;Health;holistic approach;Human;Immune;Immune system;innovation;insight;Insulin-Dependent Diabetes Mellitus;Investigation;Link;Maps;Medicine;Modeling;Molecular;mouse model;Multiple Sclerosis;Mutation;Nucleic Acid Regulatory Sequences;Patients;Play;preservation;prevent;Proteins;Regulation;Regulatory Element;Rheumatoid Arthritis;Role;Self Tolerance;Signal Transduction;T-Cell Development;T-Cell Receptor;T-Lymphocyte;Testing;Therapeutic;Thymus Gland;trait;Untranslated RNA;Variant;Work

PROJECT_TITLE: Connecting epigenetic programming of T cells with molecular traits of the immune system in health and disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MGG-D (55)]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Dietary Supplements;Genetics;Nutrition

ORG_CITY: Newark

ORG_DEPT: BIOLOGY

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: Project Narrative Proper epigenetic gene regulation is required for health and often disrupted in disease. Metabolism supports this regulation by converting nutrients into usable chemical forms for the placement of a one- carbon unit, known as methylation, onto chromatin. The goal of this research program is to use quantitative metabolism techniques to investigate how metabolic homeostasis is achieved through production of these one-carbon units to meet demand for methylation.

PI_NAMEs: MCBRIDE, MATTHEW JOSEPH (contact)

PROGRAM_OFFICER_NAME: BARSKI, OLEG

PROJECT_TERMS: Address;Amino Acids;Carbon;Cell Proliferation;Chemicals;Chromatin;Chromatin Structure;Consumption;Development;dietary;Disease;DNA Methylation;Epigenetic Process;epigenetic regulation;Gene Expression;Gene Expression Regulation;Glycine;Goals;Grant;hallmarks of aging;Health;histone methylation;Histones;Homeostasis;In Vitro;in vivo;insight;Knowledge;liquid chromatography mass spectrometry;Maintenance;Malignant Neoplasms;Measures;Mediating;Metabolic;Metabolism;Methionine;Methods;Methylation;Modernization;Natural regeneration;novel;Nutrient;Nutrient availability;Production;programs;Reaction;Regulation;Research;Role;S-Adenosylhomocysteine;S-Adenosylmethionine;Serine;Source;stable isotope;Tail;Techniques;Therapeutic;Tissue Differentiation;Tissues;tool;usability;Vision

PROJECT_TITLE: Homeostasis of one-carbon metabolism to support epigenetic methylation

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Clinical Research;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Machine Learning and Artificial Intelligence;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: ATLANTA

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE This study will characterize the poor outcomes of Shigella diarrhea that can be prevented by appropriate antibiotic treatment and evaluate strategies to identify Shigella at the point-of-care to target therapy. The results from the study will define the value of targeted treatment interventions for Shigella and optimize their implementation. Targeted treatment of Shigella may reduce morbidity and mortality from Shigella diarrhea among children in low-resource settings while reducing antibiotic use for diarrhea overall, limiting antimicrobial resistance.

PI_NAMEs: ROGAWSKI MCQUADE, ELIZABETH TACKET (contact)

PROGRAM_OFFICER_NAME: BAQAR, SHAHIDA

PROJECT_TERMS: 5 year old;Age;Antibiotic Therapy;Antibiotics;Antimicrobial Resistance;Bangladesh;Bangladeshi;Biological Markers;Blood;Caring;Cessation of life;Child;Clinical;Clinical Data;Clinical Management;clinical predictors;cohort;Collaborations;Communicable Diseases;Data;design;Diagnosis;diagnostic value;Diarrhea;Dysentery;Effectiveness;Enrollment;Enteral;enteric pathogen;Epidemiologic Methods;Epidemiologist;Etiology;evidence base;Feces;field study;Goals;Growth;Guidelines;Health care facility;Health Services Accessibility;high risk population;hospital readmission;Hospital Referrals;Hospitalization;Hospitals;improved;improved outcome;Inflammatory;Intervention;Knowledge;low and middle-income countries;Machine Learning;machine learning method;Medical;Modeling;molecular diagnostics;Morbidity - disease rate;mortality;novel;novel marker;optimal treatments;Outcome;overtreatment;Performance;point of care;Population;postneonatal mortality;prediction algorithm;prevent;Prospective cohort;Public Health;public health intervention;Recommendation;Research;Resource-limited setting;Resources;Rotavirus;Seasonal Variations;Seasons;Sensitivity and Specificity;Shigella;Shigella Infections;Specific qualifier value;Syndrome;Tanzania;targeted treatment;Time;treatment guidelines;treatment strategy;Viral;Work;World Health Organization

PROJECT_TITLE: Targeted antibiotic therapy for Shigella among children in low-resource settings

STUDY_SECTION: PRID

STUDY_SECTION_NAME: Population based Research in Infectious Disease Study Section[PRID]


NIH_SPENDING_CATS: Behavioral and Social Science;Burden of Illness;Cardiovascular;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Heart Disease;Networking and Information Technology R&D (NITRD);Prevention;Primary Health Care;Rural Health;Social Determinants of Health;Telehealth

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: PROJECT NARRATIVE  In the United States, working-age adults (age 20 to 64 years) in rural areas experience significantly higher cardiovascular mortality rates than their urban counterparts due to worse access to care and a higher burden of risk factors, and there is concern that the spillover effects of the COVID-19 pandemic (disruptions in care, unemployment, financial strain) will further widen these differences for years to come. We will use a combination of national datasets to understand changes in access to care and cardiovascular health for rural working-age adults after the pandemic, determine the potential effects of changing the age of Medicare eligibility on access to care and the screening, treatment, and control of cardiovascular risk factors for this population, and evaluate whether the expansion of broadband internet in rural areas leads to increased telemedicine use and improvements in cardiovascular health. The identification of policies that improve access, care delivery, and cardiovascular health in rural communities could have major public health implications, and ultimately inform strategies to improve cardiovascular outcomes nationwide.

PI_NAMEs: WADHERA, RISHI KUMAR (contact)

PROGRAM_OFFICER_NAME: COADY, SEAN

PROJECT_TERMS: Acute;Address;Adoption;Adult;Affect;Age;Ambulatory Care;American;Behavioral Risk Factor Surveillance System;Biometry;Cardiovascular Diseases;cardiovascular disorder epidemiology;cardiovascular health;cardiovascular risk factor;Cardiovascular system;care delivery;Caring;Cessation of life;Cholesterol;Chronic Care;COVID-19 pandemic;COVID-19 pandemic effects;Data;Data Set;Death Rate;design;Diabetes Mellitus;digital divide;early onset;Economics;Eligibility Determination;Enrollment;Equity;experience;falls;Federal Government;Financial Hardship;Goals;health care availability;Health Services Accessibility;Heart failure;Hospitalization;Hospitals;Hyperlipidemia;Hypertension;Improve Access;improved;improved outcome;Incidence;Inequity;Infrastructure;Inpatients;insight;Insurance Coverage;Internet;Investments;Laboratories;Medical;Medicare;Morbidity - disease rate;mortality;multidimensional data;Myocardial Infarction;National Health and Nutrition Examination Survey;Occupations;Outpatients;pandemic disease;Persons;Policies;Policy Maker;Population;population health;post-pandemic;Prevalence;preventable death;Preventive care;programs;Public Health;Research;Risk Factors;Rural;rural America;rural area;Rural Community;rural counties;Rural Health;Rural Hospitals;Rural Population;screening;social;Source;Stroke;Surveys;Telemedicine;telestroke;Unemployment;Uninsured;United States;urban area;Visit;years of life lost

PROJECT_TITLE: Strategies to Improve the Cardiovascular Health of Rural Working-Age Adults in the United States

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 HSS-B (90)]


NIH_SPENDING_CATS: Neurosciences

ORG_CITY: SAINT LOUIS

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

PHR: PROJECT NARRATIVE (PARENT GRANT) Metabolic flexibility is essential for cellular and organismal survival in times of energetic stress. Our work aims to decipher the molecular pathways that enable energetic cells like neurons to fine-tune their metabolic programs to energy demand and thereby perform highly complex functions.

PI_NAMEs: ASHRAFI, GHAZALEH  (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TERMS: Bioenergetics;Biosensor;Cell Energetics;Cell Physiology;cell type;Cells;cellular imaging;Communities;Complex;Coupled;Diabetes Mellitus;Disease;Endocytosis;Energy Metabolism;Eukaryotic Cell;flexibility;Gene Expression Profile;Genomics;Glycolysis;Goals;Laboratories;Leigh Disease;Metabolic;Metabolic dysfunction;metabolic imaging;Metabolism;Mitochondria;Molecular;Muscle Fibers;Myopathy;Neurons;new technology;novel;optical imaging;Oxidative Phosphorylation;parent grant;Pathway interactions;Process;Production;programs;Regulation;Research;Stress;Synaptic Vesicles;tool;transcriptomics;Work

PROJECT_TITLE: Cellular mechanisms of bioenergetic plasticity


ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative Product labeling for the nicotine concentration of liquids used in Electronic Nicotine Delivery Systems (ENDS) currently is not sufficiently informative to the public, so this project will improve upon FDA-required labeling of ENDS nicotine concentration by producing an optimized nicotine concentration label that is linked to an objective scaling metric: the nicotine content of combustible cigarettes. We expect our new concentration label to improve understanding of the nicotine strength and, secondarily, addiction potential of ENDS liquids among youth and adults. The project also will generate data on the utility of labeling nicotine emissions from closed- system ENDS (i.e., non-refillable pod/cartridge-based devices and disposables) via nicotine flux, a complex but potentially more informative index of nicotine from closed-system ENDS that better approximates nicotine delivery than does liquid nicotine concentration alone.

PI_NAMEs: MOREAN, MEGHAN E (contact)

PROGRAM_OFFICER_NAME: FEDOTA, JOHN RAPHAEL

PROJECT_TERMS: addiction;addiction liability;Address;Adult;Affect;Area;Authorization documentation;Behavior;Categories;Characteristics;Cigarette;cigarette user;Code;Color;combustible cigarette;Communication;Complex;Data;Descriptor;design;Development;Devices;Electronic Nicotine Delivery Systems;evidence base;Expert Opinion;Exposure to;Feedback;Focus Groups;Grant;Health Benefit;improved;indexing;innovation;interest;JUUL;Label;Lead;Link;liquid nicotine;Liquid substance;Marketing;Nicotine;Nicotine Dependence;nicotine vapor;novel;Participant;Performance;Persons;pilot test;prevent;Product Labeling;Proxy;Public Health;Qualitative Methods;Reporting;Research;Risk;Sales;Smoke;Smoker;smoking cessation;Surveys;System;Testing;Text;tobacco advertising;tobacco products;United States;uptake;Vulnerable Populations;Withdrawal;Work;Youth

PROJECT_TITLE: Using Novel Labeling to Improve Public Understanding of Nicotine in Electronic Nicotine Delivery Systems (ENDS): Nicotine Concentration and Nicotine Flux

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 SCIL-E (56)]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Fentanyl Misuse and Addiction;Lung;Neurosciences;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative Opioids interfere with the normal functioning of brainstem circuitry that controls breathing leading to respiratory depression and cessation of breathing (apnea). The proposed studies will provide mechanistic details on the neurons that continue to function unopposed during opioid exposure to determine the role of these opioid- insensitive neurons in respiratory failure. The outcomes of this research will advance our understanding of the pontomedullary circuitry that controls breathing and mechanisms of opioid-induced respiratory depression.

PI_NAMEs: LEVITT, ERICA SAWYER (contact)

PROGRAM_OFFICER_NAME: LAPOSKY, AARON D

PROJECT_TERMS: Adult;Anesthesia procedures;Apnea;Area;Attenuated;Brain;brain control;Brain Stem;Breathing;Cause of Death;Cell Nucleus;cell type;Complex;Data;Dose;Electrophysiology (science);Equilibrium;excitatory neuron;expiration;Exposure to;Failure;Fentanyl;fentanyl overdose;Fire - disasters;Future;Gene Modified;Genetic;Glutamates;Goals;In Situ;in vivo;inhibitory neuron;innovation;Knowledge;Label;Measurement;Mediator;Modeling;Morphine;mu opioid receptors;Mus;neural circuit;Neurons;neurotransmission;non-opioid analgesic;Opioid;Opioid agonist;opioid exposure;opioid mortality;opioid overdose;opioid use;Optics;optogenetics;Outcomes Research;Output;Perfusion;Phenotype;Pontine structure;Population;preBotzinger complex;Preparation;prevent;Public Health;Publishing;Research;respiratory;Respiratory Center;Respiratory Failure;Role;side effect;Site;Slice;Synapses;System;Testing;Tidal Volume;Ventilatory Depression

PROJECT_TITLE: Brainstem mechanisms of opioid-induced respiratory depression

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_CITY: MADISON

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it addresses the mutation process, which gives rise to genetic variants that are responsible for heritable disorders and cancer. This work will significantly advance our understanding of how fundamental evolutionary forces influence genome maintenance. By testing theories for how DNA replication and repair processes evolve and mechanistically affect the genome, this research will improve our ability to predict genetic change, which is relevant to the core mission of the NIGMS.

PI_NAMEs: SHARP, NATHANIEL  (contact)

PROGRAM_OFFICER_NAME: ADKINS, RONALD

PROJECT_TERMS: Address;Affect;Alleles;Aneuploidy;asexual;Biological;causal variant;cell type;Cells;Chromosomes;Consensus;Dimensions;Diploidy;DNA biosynthesis;DNA Double Strand Break;DNA Repair;driver mutation;Drosophila genus;Equilibrium;Evolution;Female;Genetic;genetic predictors;Genetic Recombination;genetic variant;Genetic Variation;Genome;genomic data;Genomics;Germ Lines;Goals;Haploidy;Hereditary Disease;improved;Karyotype;Life Cycle Stages;Maintenance;male;Malignant Neoplasms;Mating Types;Measures;Meiosis;Mission;Modeling;Molecular;mutant;Mutation;Mutation Spectra;National Institute of General Medical Sciences;novel;Organism;parental role;Pattern;Performance;Ploidies;Process;Public Health;reproductive;Research;sex;Sex Bias;Sex Differences;Shapes;System;Techniques;Testing;theories;Time;trait;transmission process;Variant;Work;Yeasts

PROJECT_TITLE: The evolutionary and genomic drivers of mutation spectra

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Project Narratives The progression of complex diseases, such as cancer, Alzheimer’s disease, and diabetes, is driven by interactions among various cell types present at disease sites. This project aims to develop innovative computational methods for inferring the cell-type-specific protein dysregulation. Successful completion of the project will significantly advance the translation of both current and emerging large-scale proteogenomic data into accurate protein-based clinical biomarkers and effective therapeutic targets.

PI_NAMEs: HUANG, CHEN  (contact)

PROGRAM_OFFICER_NAME: YU, GUOQIN

PROJECT_TERMS: Address;Alzheimer's Disease;Biological;cell type;Clinical;clinical biomarkers;Complex;Computing Methodologies;Data;Data Analyses;data portal;Data Set;Diabetes Mellitus;Disease;druggable target;genome-wide;Goals;human disease;innovation;Malignant Neoplasms;Maps;Mass Spectrum Analysis;Methods;Modification;Molecular;Molecular Abnormality;molecular phenotype;multiple omics;Nature;next generation sequencing;Peptides;Phenotype;Post-Translational Protein Processing;protein expression;protein profiling;Proteins;proteogenomics;Proteomics;public database;Regulation;Research Personnel;RNA;Sampling;Signal Pathway;single-cell RNA sequencing;Site;Therapeutic;therapeutic target;therapeutically effective;transcriptomics;Translations

PROJECT_TITLE: Integrative Approaches to Study Cell-Type-Specific Protein Dysregulation in Human Diseases

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MBBC-F (55)]


ORG_CITY: WACO

ORG_NAME: BAYLOR UNIVERSITY

ORG_STATE: TX

PHR: Project Narrative Enzymes are dynamic and flexible proteins that catalyze chemical reactions in the living cell. These motions are vital to the proper functions of these enzymes as well as the discovery of drug candidates to modulate the activity of these molecules. The project studies the dynamics of enzymes involved in metabolism by time-resolved structural methods and develops techniques to observe the movements of these flexible proteins in response to stimuli, which will improve our understandings of these important molecules.

PI_NAMEs: CLINGER, JONATHAN  (contact)

PROJECT_TERMS: Amaze;Amino Acids;Binding;Binding Sites;Biochemical Reaction;Catabolism;Catalysis;catalyst;Cell Physiology;Cells;chemical reaction;Crystallography;design;Disease;Disease Management;drug candidate;Drug Design;Drug Targeting;Engineering;Ensure;enzyme activity;Enzyme Kinetics;enzyme structure;Enzymes;experimental study;flexibility;Future;Goals;Growth;Health;Human;improved;inhibitor;Kinetics;Knowledge;Learning;Life;Metabolism;method development;Methods;millisecond;Motion;Movement;Outcome;Pathway interactions;Pharmaceutical Preparations;programs;Property;Proteins;Reaction;Research;Research Design;Research Personnel;Resolution;response;Stimulus;structural biology;Structure;success;System;Techniques;Temperature;Time;time use;Work

PROJECT_TITLE: Time-Resolved and Multi-Temperature Structural Biology to Understand Dynamic Enzyme Catalysis

STUDY_SECTION: MRAE

STUDY_SECTION_NAME: Maximizing Investigators' Research Award - E Study Section[MRAE]


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Social Determinants of Health

ORG_CITY: CAMBRIDGE

ORG_DEPT: MISCELLANEOUS

ORG_NAME: HARVARD UNIVERSITY

PHR: PROJECT NARRATIVE The proposed project will provide novel large-scale data on emerging workplace practices in the service sector related to surveillance and sanctioning, schedule unpredictability and constraint, and automation, and assess their implications for worker’s health and healthy aging. Our study will reveal how temporal dimensions of job quality differentially affect health across the life course and how social supports at the individual and macro levels may buffer any negative effects on health. The proposed data collection will take advantage of natural experiments at the local and company level that induce exogenous changes in job quality and thus build the evidence-base on the effects of emerging workplace practices on population health.

PI_NAMEs: HARKNETT, KRISTEN ;SCHNEIDER, DANNY  (contact)

PROGRAM_OFFICER_NAME: JAIN, KRITI MUNJAL

PROJECT_TERMS: Advertisements;Advertising;Affect;Age;American;Area;Automation;Buffers;caregiving;Cities;Conflict (Psychology);cost;Country;Data;Data Collection;Data Set;Data Sources;deprivation;design;Dimensions;Economic Conditions;Economics;Employee;evidence base;expectation;Exposure to;Facebook;Family;fast food;Fringe Benefit;Future;Health;Health behavior;healthy aging;human old age (65+);Individual;innovation;insight;Instagram;Knowledge;large scale data;Laws;Life;Life Cycle Stages;Link;Longitudinal Surveys;Measures;Mediation;Mental Health;Methods;Modeling;Natural experiment;new technology;novel;novel strategies;Occupations;Outcome;Personal Satisfaction;physical conditioning;Policies;Policy Maker;Policy Making;Population;population health;recruit;Research;Research Personnel;Role;safety net;Sampling;Schedule;Services;Shapes;Signal Transduction;social;social relationships;Social support;Social Work;Speed;Surveys;Target Populations;Testing;Time;Uncertainty;Variant;Wages;Woman;Work;Workplace

PROJECT_TITLE: Effects of Job Quality in the Service Sector on Health-Related Outcomes Across the Life Course

STUDY_SECTION: SSPA

STUDY_SECTION_NAME: Social Sciences and Population Studies A Study Section[SSPA]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics;Human Genome;Neurosciences;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_DEPT: OPHTHALMOLOGY

PHR: PROJECT NARRATIVE This research aims to uncover the molecular function of the retinal disease gene H3.3 in retinal cell fate specification and differentiation. Individuals with mutations in H3.3 have devastating neurodevelopmental issues and specific mutations have been linked to retinal degeneration. The outcomes of this research will advance our understanding of this key regulator of gene expression and genomic organization, which is the first step toward treatment of this devastating disease.

PI_NAMEs: RUZYCKI, PHILIP ANDREW (contact)

PROGRAM_OFFICER_NAME: WRIGHT, CHARLES BAKER

PROJECT_TERMS: Acetylation;Affect;Amino Acids;ATAC-seq;Blindness;Cell Cycle;Cell Differentiation process;Cell division;cell fate specification;cell type;Cells;cellular development;Cessation of life;Data;Deposition;derepression;Development;Disease;DNA;early onset;Enhancers;Epigenetic Process;epigenome;epigenomics;Essential Amino Acids;experimental study;Eye;Failure;Future;Gene Expression;Gene Expression Regulation;Genes;Genetic Transcription;Genome;Genomics;Goals;Histone H3;Histones;Homeostasis;horizontal cell;Human;in vivo;Individual;Investigation;Isomerism;Label;Length;Link;Methylation;Modification;Molecular;Molecular Probes;Morphology;mouse model;Mus;mutant;Mutation;mutation screening;Natural regeneration;Nervous System Disorder;Neural Retina;Neurons;Outcome;Outcomes Research;Patients;Phenotype;Photoreceptors;postmitotic;Process;progenitor;Prognosis;Protein Isoforms;Regulator Genes;Reporting;Research;Retina;Retinal Degeneration;Retinal Diseases;retinal progenitor cell;retinal rods;Rod;Role;Specific qualifier value;Stem cell transplant;Tail;telomere;Telomere Maintenance;Testing;Therapeutic;therapy design;therapy development;treatment strategy;Variant;Visual impairment

PROJECT_TITLE: Homeostasis of the Retinal Epigenome

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CDB-F (02)]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Childhood Obesity;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;HIV/AIDS;Infectious Diseases;Obesity;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention;Women's Health Research

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative HIV-uninfected individuals born to mothers with HIV are known to exhibit adverse health outcomes in early life, yet the long-term clinical consequences for this population – exceeding 18 million people worldwide – are largely unknown. This project will delineate metabolic and immune sequelae of in utero HIV exposure among HIV- uninfected young adults, and identify mechanisms that may contribute to these outcomes. Only by characterizing lifelong disease risk among HIV-exposed but uninfected individuals can we optimize screening, prevention, and treatment strategies for this group.

PI_NAMEs: FOURMAN, LINDSAY TARA (contact)

PROGRAM_OFFICER_NAME: RUSSO, DENISE

PROJECT_TERMS: abdominal fat;Acceleration;Address;Administrative Supplement;Adolescent and Young Adult;Adolescent obesity;Adult;Airway Disease;antiretroviral therapy;Award;Behavioral;Biometry;Blood Pressure;career;career development;CD4 Lymphocyte Count;Cells;Child;Childbirth;Clinical;Clinical Investigator;Cohort Studies;Communicable Diseases;comorbidity;comparison control;Data;Dedications;design;Development;Development Plans;Diabetes Mellitus;Disease;disorder risk;DNA Methylation;Endocrinologist;Endocrinology;Epidemiology;Epigenetic Process;Event;Exhibits;Exposure to;Fatty acid glycerol esters;Fetal Development;Functional disorder;Funding;Genes;Glucose Intolerance;Goals;Growth;Health;health determinants;Hepatic;high body mass index;HIV;HIV-exposed uninfected infant;Immune;immune activation;Immunologics;Immunology;Impairment;in utero;indexing;Individual;Infant;Infection;Inflammation;inflammatory marker;innovation;International;intrauterine environment;Investments;Lead;lens;Life;Link;Literature;maternal diabetes;maternal obesity;medical schools;Mentors;Metabolic;Metabolic Diseases;Metabolism;methylation pattern;mitochondrial dysfunction;Modification;Molecular;Mothers;novel;Obesity;Outcome;Pathogenesis;Pathologic;Pathway interactions;patient population;peer;Persons;Phenotype;Population;Predisposition;prenatal;prenatal exposure;Prevalence;prevent;Prevention;Prevention strategy;prospective;Prospective Studies;Public Health;Research;research and development;Research Personnel;Risk;Risk Factors;Role;screening;skills;social;Sterile coverings;Testing;Time;Training;training opportunity;treatment strategy;Work;young adult;young mother

PROJECT_TITLE: Administrative Supplement - In Utero HIV Exposure and Metabolic Disease Risk in HIV-Uninfected Young Adults