NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Kidney Disease;Orphan Drug;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases;Social Determinants of Health

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: PROJECT NARRATIVE There is a significant racial disparity in renal cell carcinoma. In this proposal, we will identify and characterize oncogenic drivers enriched in tumors from patients of African ancestry. These studies will uncover therapeutic targets for this patient population.

PI_NAMEs: TAYLOR, ALISON M.;ZHANG, JIAN  (contact)

PROGRAM_OFFICER_NAME: WALLACE, TIFFANY A

PROJECT_TERMS: 22q;African;African ancestry;Aneuploidy;Biological;Biological Factors;Biology;black patient;Black race;Carrots - dietary;Cell Line;chromosome mutation;Chromosomes;Clear Cell;Clear cell renal cell carcinoma;Clinical;cohort;Collaborations;Computer Analysis;Coupled;Data;Data Set;Diagnostic tests;Disease;Disparity;disparity reduction;DNA Sequence Alteration;Early Diagnosis;Environmental Risk Factor;European;European ancestry;Event;exome sequencing;experimental study;Foundations;functional genomics;Genes;Genetic;Genome engineering;genome sequencing;genomic data;Genomics;health disparity;improved;Incidence;insight;kidney cell;Knowledge;Medicine;Modeling;Molecular;Mutate;Mutation;Neurofibromin 2;new therapeutic target;novel;novel therapeutics;Oncogenes;Oncogenic;Outcome;Papillary;patient population;Patients;Phenotype;Population;precision medicine;Prognostic Marker;public database;racial disparity;racial population;Renal Carcinoma;Renal Cell Carcinoma;Reporting;Research;Sample Size;Sampling;Socioeconomic Status;structural determinants;survival disparity;therapeutic target;transcriptome sequencing;tumor;Tumor Suppressor Genes;tumorigenesis;Variant;VHL gene;VHL mutation;whole genome

PROJECT_TITLE: Genomics of Renal Cancer in Patients of African Ancestry

STUDY_SECTION: BMCD

STUDY_SECTION_NAME: Basic Mechanisms of Cancer Health Disparities Study Section[BMCD]


ADMINISTERING_IC: AG

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects;Prevention;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: Aurora

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: NARRATIVE Concussion or mild traumatic brain injury (mTBI) is a leading cause of disability in older adults, military service personnel, and athletes. Repeated concussions may lead to increased risk for dementia, but biomarkers which are both diagnostic of mTBI and prognostic for AD have not been identified. The current project is focused on identifying targets for drug development and novel biomarkers for this condition.

PI_NAMEs: GRANHOLM-BENTLEY, ANN-CHARLOTTE ESTHER (contact);LEDREUX, AURÉLIE ;LINSEMAN, DANIEL A

PROGRAM_OFFICER_NAME: OPANASHUK, LISA A

PROJECT_TERMS: 3xTg-AD mouse;Acceleration;Acute;AD transgenic mice;Adult;age related;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease related dementia;Alzheimer's disease risk;Alzheimer’s disease biomarker;American;Amyloid;amyloid pathology;Assessment tool;Astrocytes;Biological;Biological Markers;Biology;biomarker panel;Blood;Blood specimen;blood-brain barrier crossing;Brain;Brain Concussion;brain health;Brain Injuries;Brain Pathology;cell cortex;Cells;Central Nervous System;Clinical;Cognitive;Cognitive deficits;cohort;Cohort Studies;Data;Dementia;dementia risk;design;Diagnostic;diagnostic tool;disability;Disease;drug development;Drug Targeting;epidemiology study;equilibration disorder;Equilibrium;exosome;experimental study;Exposure to;extracellular vesicles;Female;Future;Genetic;Genetic Diseases;Genetic Predisposition to Disease;Goals;Grant;Health;Human;Human Resources;Ice Hockey;Impaired cognition;In Vitro;in vivo;Inflammation;Injections;Injury;Label;Lacrosse;Lead;Longitudinal Studies;male;Manufactured football;Measurement;Mental Depression;mild traumatic brain injury;Military Personnel;military service;Molecular;mouse model;Mus;nanosized;Neurodegenerative Disorders;Neurons;neuropathology;Newborn Infant;normal aging;novel;novel marker;old mice;older adult;Pathologic;Pathology;Preventive treatment;primary outcome;prion-like;prognostic;programs;pup;Research;Research Personnel;response;Risk;secondary outcome;Sports;Stream;Surface;tau aggregation;tau Proteins;Technology;Testing;Text;Transgenes;Trauma;uptake;Wild Type Mouse

PROJECT_TITLE: Exosome biology in Alzheimer's disease and concussion


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: DAYTON

ORG_DEPT: PHYSIOLOGY

ORG_NAME: WRIGHT STATE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative Despite much effort to identify mechanisms underlying amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration dementia (FTLD or FTD), effective treatments remain elusive. Motoneuron (MN) excitability dysfunction is tightly linked to disease pathology, yet to date, excitability dysregulation has not been examined in the recent rNLS8 mouse model, which recapitulates pathologic TDP43 inclusions seen in MNs in >90% of ALS patients and in FTD patients. This proposal is relevant to public health because it will examine excitability dysregulation in this highly relevant model of ALS/FTD.

PI_NAMEs: ELBASIOUNY, SHERIF M (contact)

PROGRAM_OFFICER_NAME: GUBITZ, AMELIE

PROJECT_TERMS: ALS patients;Amygdaloid structure;Amyotrophic Lateral Sclerosis;Animal Model;Area;Automobile Driving;Brain;Cessation of life;cholinergic;comorbidity;Compensation;Conflict (Psychology);Corpus striatum structure;Data;Dementia;Disease;DNA-Binding Proteins;Down-Regulation;Drug Targeting;effective therapy;Electrophysiology (science);Event;Exhibits;FDA approved;Frontotemporal Dementia;Frontotemporal Lobar Degenerations;frontotemporal lobar dementia amyotrophic lateral sclerosis;Functional disorder;Grant;Hippocampus;Hyperactivity;Immunohistochemistry;Individual;Ion Channel;Knowledge;Kv2.1 channel;Life;Link;Measures;Modeling;Motor Neurons;mouse model;Mus;Muscle fasciculation;mutant;Mutation;neuron loss;neuronal excitability;Neurons;neuroprotection;new therapeutic target;novel;Paralysed;Pathogenesis;Pathologic;Pathology;Pathway interactions;Patients;Pharmaceutical Preparations;Play;protein TDP-43;Public Health;Reporting;Research;response;Riluzole;Role;Severities;Spinal;Spinal Cord;Superoxide Dismutase;Symptoms;Synapses;synaptic function;TDP-43 aggregation;Western Blotting

PROJECT_TITLE: Excitability dysfunction mechanisms underlying the TDP43-dependent ALS and FTD pathogenesis

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Complementary and Integrative Health;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: GAINESVILLE

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Project Narrative This competing continuation of a 15-year predoctoral training program is focused on research training for the design and evaluation of cognitive interventions for older adults. The program has three substantive emphases: (a) behavioral interventions (e.g., cognitive training, exercise, mindfulness) for unimpaired older adults; (b) multi-component compensatory interventions for persons with cognitive impairment; (c) neuromodulation/stimulation interventions. We propose to continue this successful program with six pre- doctoral slots a year, reserved for students beyond the first year of doctoral study.

PI_NAMEs: MARSISKE, MICHAEL  (contact);SMITH, GLENN E.

PROGRAM_OFFICER_NAME: TORRES, DELANY

PROJECT_TERMS: Aging;Alzheimer's Disease;Cognition;Nonpharmacologic Therapy;Research Training

PROJECT_TITLE: Research Training in Non-Pharmacological Interventions for Cognition in Aging, MCI, and Alzheimer's Disease


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biomedical Imaging;Biotechnology;Cancer;Immunotherapy;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: BALTIMORE

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative Improvements in outcomes with current chemotherapy and surgery treatment approaches for patients with osteosarcoma have plateaued over the past three decades, necessitating new treatment paradigms. Our proposal aims to develop a novel therapy for osteosarcoma using Magnetic Resonance Imaging (MRI)-guided cryotherapy in conjunction with intratumoral injection of an immune adjuvant in the clinically relevant animal model of spontaneously occurring osteosarcoma in client-owned dogs with the intent of priming an adaptive immune response capable of delaying or preventing the occurrence of metastatic disease. A successful immunotherapy approach for the treatment of osteosarcoma would provide significant benefit to patients for whom current treatments result in substantial short-term and long-term side effects from toxic chemotherapy.

PI_NAMEs: KRAITCHMAN, DARA L (contact);LADLE, BRIAN H.

PROGRAM_OFFICER_NAME: KIM, BOKLYE

PROJECT_TERMS: Academic Medical Centers;adaptive immune response;Adaptive Immune System;Adult;Agonist;Amino Acid Sequence;Amputation;Anatomy;Animal Hospitals;Animal Model;anti-tumor immune response;Antigen Presentation;Antigen-Presenting Cells;Biological Assay;Biological Models;Biotechnology;bone;Bone neoplasms;cancer therapy;Canis familiaris;cell injury;Cells;chemotherapy;Child;Client;clinical outcome measures;Clinical Trials;clinically relevant;Cold Therapy;Collaborations;Combined Modality Therapy;comparative;Correlative Study;Cryosurgery;cytokine;Disease;Disease Progression;Distant;Equipment;Exposure to;Freezing;Future;Goals;Human;image guided;image guided therapy;image translation;imaging system;Immune;immune activation;immune cell infiltrate;Immune response;Immune system;Immunity;Immunoassay;Immunohistochemistry;Immunologic Adjuvants;Immunologics;Immunooncology;immunoregulation;Immunosuppression;Immunotherapy;improved;improved outcome;in situ vaccine;Incidence;Infiltration;Injections;innovation;insight;Interferon Type I;Interferon-beta;Ionizing radiation;Learning;Macrophage;Magnetic Resonance Imaging;Malignant Childhood Neoplasm;Malignant Neoplasms;Maps;medical schools;meetings;Metastatic/Recurrent;Modality;model development;Modeling;Myeloid Cells;Necrosis;neoplastic cell;non-invasive imaging;Nonmetastatic;Normal tissue morphology;novel;novel therapeutic intervention;novel therapeutics;Nucleotides;Oncology;Operative Surgical Procedures;Osteosarcoma;Outcome;Pathway interactions;Patient-Focused Outcomes;Patients;Phase I Clinical Trials;Positioning Attribute;preservation;prevent;Randomized;Recording of previous events;recruit;Safety;Sarcoma;Secondary to;side effect;Solid Neoplasm;standard care;standard of care;Stimulator of Interferon Genes;System;T-Lymphocyte;Technology;Testing;Toxic effect;Translations;treatment and outcome;treatment strategy;trial comparing;tumor;tumor ablation;Tumor Antigens;Tumor Tissue;Virus Diseases;young adult

PROJECT_TITLE: MRI-Guided Cryoablation and Imaging-Guided Intratumoral Delivery of STING Agonist Immunotherapy to Target Localized and Metastatic Canine Osteosarcoma

STUDY_SECTION: IGIS

STUDY_SECTION_NAME: Imaging Guided Interventions and Surgery Study Section[IGIS]


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cancer;Cannabinoid Research;Chronic Pain;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Natural Products;Opioids;Pain Research;Palliative Care;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse;Therapeutic Cannabinoid Research

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE Patients with cancer may use cannabis to manage symptoms, such as pain, and potentially reduce opioid use. Cannabis’ status as a Schedule 1 substance has made it difficult to study the role of cannabis use on pain and opioid use among cancer patients. This study will generate new knowledge to inform clinical practice and guidelines related to cannabis use in cancer pain and symptom management.

PI_NAMEs: ASHARE, REBECCA ;MEGHANI, SALIMAH H. (contact);WORSTER, BROOKE

PROGRAM_OFFICER_NAME: RISCUTA, GABRIELA

PROJECT_TERMS: Adjuvant Analgesic;Adult;African American;American;Anxiety;cancer health disparity;cancer pain;Cancer Pain Management;Cancer Patient;Cancer Science;cancer therapy;Cannabidiol;Cannabinoids;Cannabis;Cannabis policy;cannabis use behavior;Characteristics;Classification;Clinical;clinical practice;Clinical Practice Guideline;Cohort Studies;Cross-Sectional Studies;Data;Databases;design;District of Columbia;Ecological momentary assessment;Enrollment;Exhibits;falls;Female;Frequencies;Funding Agency;Guidelines;health disparity;Health system;Hydrocodone;improved;indexing;Inhalation;Interdisciplinary Study;interest;Knowledge;Laws;Malignant Neoplasms;Marijuana;marijuana legalization;marijuana use;marijuana user;Measures;Medical;Medical Marijuana;Medical Oncologist;Medicine;Methodology;National Cancer Institute;National Comprehensive Cancer Network;New England;Oncologist;Oncology;Opioid;opioid misuse;opioid therapy;opioid use;Oral;Outcome;Oxycodone;Pain;Pain management;pain outcome;Patient Outcomes Assessments;Patients;Pharmaceutical Preparations;pill;Plants;Practice Guidelines;prescription monitoring program;prescription opioid;Prospective cohort;Quality of life;Race;racial disparity;Recommendation;Reporting;Research;Research Design;Respondent;Role;Route;Sampling;Schedule;Science;Severities;side effect;Site;Sleep;Sleeplessness;Solid;Source;substance misuse;Surveys;symptom management;Telephone;Testing;Tetrahydrocannabinol;Time;tumor;United States;United States Food and Drug Administration;Work

PROJECT_TITLE: Cannabis use and outcomes in ambulatory patients with cancer: A 12-month cohort study

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-A(90)]


ADMINISTERING_IC: DA

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Opioid Misuse and Addiction;Opioids;Recovery Support Services;Rehabilitation;Social Determinants of Health;Substance Misuse

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE  The opioid crisis has caused a national decline in average U.S. life-expectancy necessitating a declaration of a federal public health emergency. Opioid use disorder is a chronic condition best managed with long-term use of medications, but even with medication use, compared to those suffering from other substance use disorders, individuals suffering from opioid use disorder continue to suffer from additional deficits. Recovery Community Centers (RCCs) are designed to help individuals with opioid use disorder overcome such deficits, but while promising, systematic research is sorely lacking. This project engages multiple relevant stakeholders at all levels to create a national research infrastructure to facilitate the scientific investigation into the clinical and public health utility and cost-effectiveness of RCCs for individuals suffering from opioid use disorder.

PI_NAMEs: HOEPPNER, BETTINA B. (contact)

PROGRAM_OFFICER_NAME: MARTIN, LINDSEY ANN

PROJECT_TERMS: addiction;Advanced Development;Aphorisms;biobehavior;Capital;Chronic;Clinical;Communities;community center;Contracts;cost effectiveness;Data;design;Disease remission;Education;Effectiveness;effectiveness research;efficacy research;Employment;experience;Formulation;Fostering;Funding;Goals;Growth;Health;Heart;Housing;Human Resources;Individual;interest;Investigation;Investments;Life;Life Expectancy;Lived experience;marginalization;Massachusetts;medication for opioid use disorder;meetings;Narcotics Anonymous;Occupations;opioid epidemic;opioid overdose;opioid use disorder;Outcome;overdose death;Paper;Participant;Patients;person centered;Persons;Pharmaceutical Preparations;Pilot Projects;Play;Probability;prognostic;Psychology;Public Health;public health emergency;Quality of life;Reader;Recovery;recovery community organization;recovery services;Recovery Support;Registries;Relapse;Reporting;repository;Research;Research Infrastructure;Research Institute;research study;Resources;Role;Science;Scientist;Series;Services;Slide;Social Network;Stress;Structure;Substance Use Disorder;Sum;symposium;tool;Training;Twitter;United States National Institutes of Health;United States Substance Abuse and Mental Health Services Administration;Video Recording;web site

PROJECT_TITLE: Advancing the science on recovery community centers to support persons treated with medications for opioid use disorder


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Immunization;Infectious Diseases;Malaria;Malaria Vaccine;Orphan Drug;Pediatric;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PHR: PROJECT NARRATIVE After decades of effort, one malaria vaccine has been approved by the World Health Organization, but improved malaria vaccines with higher efficacy are needed. Antibody responses to infections in infants and young children living in Sub-Saharan Africa who experience multiple malaria infections may hold the key to understanding how immunity to malaria develops. This research will investigate antibody responses against multiple malaria proteins after early childhood malaria infection with the goal of identifying proteins that could be developed into malaria vaccines.

PI_NAMEs: BERRY, ANDREA  (contact)

PROGRAM_OFFICER_NAME: MO, ANNIE X  Y

PROJECT_TERMS: Adult;Affect;Affinity;Africa;Africa South of the Sahara;African;Age;Algorithm Design;Amino Acids;Antibodies;Antibody Binding Sites;Antibody Response;Antigen Targeting;Antigens;Area;Attention;Bar Codes;Birth;Blood;Child;circumsporozoite protein;Clinical;Country;cross reactivity;Data;design;Development;DNA;early childhood;Epitopes;Erythrocytes;experience;Future;Genetic Polymorphism;geographically distant;Goals;high throughput analysis;high throughput technology;Human;Immune response;Immune system;Immunity;Immunoglobulin A;Immunoglobulin G;improved;Infant;Infection;Investigation;Kinetics;Libraries;Life Cycle Stages;Liver;Longevity;Longitudinal Studies;Malaria;malaria infection;Malaria prevention;malaria transmission;Malaria Vaccines;Malawi;Mali;Mass Spectrum Analysis;Measures;Membrane Proteins;Monoclonal Antibodies;Morbidity - disease rate;mortality;Mus;National Institute of Allergy and Infectious Disease;neural network;novel;novel vaccines;Organ;Outcome;Parasitemia;Parasites;Pattern;Peptide Library;Peptides;Plasmodium;Plasmodium falciparum;Proteins;Research;Research Design;response;Role;Sampling Studies;Serology;Serum;Site;Southern Africa;Sporozoites;Surface;Target Populations;Time;tool;vaccine candidate;Vaccine Design;vaccine development;vaccine trial;Vaccines;Variant;Work;World Health Organization

PROJECT_TITLE: Multiplex analysis of IgA and IgG antibody responses to early childhood malaria infections to inform vaccine development

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DCAI-J(03)]


NIH_SPENDING_CATS: Cancer;Immunotherapy

ORG_CITY: AUGUSTA

ORG_NAME: AUGUSTA UNIVERSITY

ORG_STATE: GA

PHR: Approaches that could combine standard chemotherapy agents with targeted immunotherapy for the treatment of cancer have the potential for high clinical impact, but it has been difficult to identify synergistic combinations. The current proposal identifies Bruton’s Tyroseine Kinase (BTK), expressed in specialized host antigen- presenting cells, as a previously unsuspected pathway that suppresses immune responses following chemotherapy. BTK-inhibitor drugs are already in use for other indications, so re-purposing these agents as part of a multi-modal chemo-immunotherapy approach is highly translatable to the clinic.

PI_NAMEs: MUNN, DAVID H. (contact)

PROGRAM_OFFICER_NAME: SINGH, ANJU

PROJECT_TERMS: Adoptive Transfer;Agammaglobulinaemia tyrosine kinase;Antigen Presentation;Antigen-Presenting Cells;Antigens;Apoptotic;cancer therapy;CD8B1 gene;Cell Death;Cell Death Induction;Cell Lineage;Cell Maturation;Cell model;Cells;chemotherapy;Clinic;Clinical;Clinical Trials;Coupled;Cross Presentation;Defect;Dendritic Cells;drug repurposing;effector T cell;FRAP1 gene;Heart;immune activation;Immune response;Immune system;Immuno-Chemotherapy;immunogenic;Immunooncology;Immunosuppression;Immunotherapy;In Situ;Infection;Inflammatory;inhibitor;inhibitor therapy;Innate Immune System;Knock-out;Ligands;Link;Macrophage;Mediating;Metabolic;Modeling;monocyte;multimodality;Mus;Myelogenous;Myeloid Cells;neoplastic cell;novel;paracrine;Pathway interactions;Population;Pre-Clinical Model;precursor cell;prevent;programs;PTEN gene;Regulatory T-Lymphocyte;response;Self Tolerance;Signal Pathway;Signal Transduction;synergism;T-Cell Activation;Testing;Therapeutic;Transforming Growth Factor beta;Translations;Tryptophan 2,3 Dioxygenase;tumor;Tumor Antigens;Tumor Immunity;tumor microenvironment;Tumor-associated macrophages;Tyrosine Kinase Inhibitor;Virus

PROJECT_TITLE: Reprogramming the TME for immunogenic antigen-presentation

STUDY_SECTION: CII

STUDY_SECTION_NAME: Cancer Immunopathology and Immunotherapy Study Section[CII]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Breast Cancer;Cancer;Nanotechnology;Women's Health Research

ORG_CITY: TUCSON

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: Project Narrative A stabilized lipid bilayer will improve the drug packaging and therapeutic delivery to the target sites compared to the conventional liposomal nanotherapeutics; and the selective cationization-induced endocytosis and transcytosis will further reinforce the intracellular uptake and tissue penetration to maximize the therapeutic potential, paving the way for the future translational applications of treating diverse human diseases.

PI_NAMEs: LU, JIANQIN  (contact)

PROGRAM_OFFICER_NAME: KODURI, SAILAJA

PROJECT_TERMS: Adsorption;Adverse effects;Affect;Alzheimer's Disease;biomaterial compatibility;Blood;Breast Cancer Model;Charge;Chemistry;Cholesterol;Circulation;Clinic;clinical translation;design;Disease;Drug Delivery Systems;Drug Kinetics;Drug Packaging;Endocytosis;Endocytosis Induction;Environment;Extracellular Matrix;Extravasation;Fortification;Future;Gene Delivery;Goals;human disease;improved;Infiltration;Intercellular Fluid;Lipid Bilayers;Liposomes;Liquid substance;Lymphoma;Mediating;Membrane;Membrane Fluidity;Membrane Lipids;nanotherapeutic;Pancreas;Penetration;Permeability;Pharmaceutical Preparations;Phospholipids;Physiological;Play;premature;pressure;prevent;programs;Property;Pulmonary Inflammation;Research;Resistance;Role;Serum Proteins;Site;Sterols;Stimulus;Structure-Activity Relationship;systemic toxicity;Technology;Therapeutic;Therapeutic Agents;therapy outcome;Time;Tissues;transcytosis;translational applications;Treatment Efficacy;triple-negative invasive breast carcinoma;uptake;Vision

PROJECT_TITLE: A fortified lipid bilayer platform for improved drug packaging and therapeutic delivery


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Nanotechnology;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Wound Healing and Care

ORG_CITY: ANN ARBOR

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Relevance: The skin is the largest organ in the body, and its primary purpose is to prevent the loss of body fluids and to protect against biological, physical, and chemical insults by maintaining a functional epithelial barrier. Compromised skin barrier due to burns occurs in more than 1 million US citizens annually and is the seventh cause of injury death in the US alone. Our research focuses on developing new therapies that combine biomaterials capable of delivering homogeneous cell suspension of epithelial cells lifted from small amounts of donor tissues to burn sites.

PI_NAMEs: BOTTINO, MARCO C;CASTILHO, ROGERIO MORAES;SQUARIZE, CRISTIANE  (contact)

PROGRAM_OFFICER_NAME: CHAO, CHIEN-CHUNG

PROJECT_TERMS: 3-Dimensional;Acceleration;Address;Affect;American;Animals;Behavior;Binding;Biocompatible Materials;biodegradable scaffold;biofabrication;bioink;Biological;Biological Testing;Biology;bioprinting;Body Fluids;Burn injury;burn model;burn wound;caprolactone;cell motility;Cell Proliferation;Cells;Cessation of life;Chemicals;Connective Tissue;Dehydration;design;diabetic ulcer;Effectiveness;efficacy evaluation;Encapsulated;Engineering;epidermal stem cell;Epidermis;Epithelial Cells;Epithelium;Extracellular Matrix Proteins;fabrication;Family suidae;Fibroblasts;FRAP1 gene;Gelatin;Genetic Transcription;Harvest;healing;Heterogeneity;Homeostasis;Housing;Human;Hydrogels;improved;in vivo;Infection;Injury;innovation;Lifting;Liquid substance;Mediating;melting;Mesenchyme;Michigan;Modification;Molecular;Nanosphere;new combination therapies;novel;novel therapeutic intervention;novel therapeutics;Organ;organ growth;Osteoblasts;Pathway interactions;Patients;PIK3CG gene;Play;Polymers;Porosity;prevent;Process;Proliferating;Quality of life;Recombinant Proteins;Recombinants;Recovery;recruit;Research;response;scaffold;severe injury;Signal Transduction;single cell sequencing;Site;Skin;skin barrier;skin regeneration;spheroids;stem cell technology;stem cells;Stratum Basale;Structure;Suspensions;Technology;Testing;Therapeutic;therapeutic effectiveness;Time;Tissue Donors;Tissue Engineering;tissue regeneration;translation to humans;Translations;Universities;Work;wound;wound closure;wound healing

PROJECT_TITLE: Combined bioprinting with stem cell technology to regenerate skin burn wounds


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Chronic Pain;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy;Physical Injury - Accidents and Adverse Effects;Sleep Research

ORG_DEPT: NEUROSURGERY

PHR: Project Narrative Spontaneous pain and poor sleep quality are the two main complaints from patients with traumatic neuropathic pain. Our preliminary results strongly support the hypothesis that sleep fragmentation after nerve injury is linked to spontaneous pain. In this project we will test formally if sleep fragmentation after nerve injury is specifically caused by ectopic activation of injured sensory neurons which in turn activate nociceptive ascending pathways. These results will test if sleep fragmentation after nerve injury can be used as a surrogate for measuring neuropathic spontaneous pain in mice. Validating a reliable outcome measure for spontaneous pain is essential to perform mechanistic studies.

PI_NAMEs: LATREMOLIERE, ALBAN A (contact)

PROGRAM_OFFICER_NAME: GREENWELL, THOMAS

PROJECT_TERMS: Acoustics;Affect;Afferent Neurons;Amyloid beta-Protein;Analgesics;Animals;Area;awake;Axon;Behavior;C Fiber;Carbamazepine;Cells;Cre driver;Data;Diameter;dorsal horn;efficacy testing;Electroencephalography;Enterobacteria phage P1 Cre recombinase;Event;experimental study;Fiber;gabapentin;Genetic;genetic approach;Glycine Receptors;Hypersensitivity;injured;Injury;Label;Lateral;Lesion;Light;Link;Local Anesthetics;Measures;mechanical allodynia;Modeling;Monitor;mouse model;Mus;Nature;Nerve;nerve injury;neural;Neurons;Neuropathy;neurotransmission;Nociception;non rapid eye movement;novel;optogenetics;Outcome Measure;Pain;pain patient;pain sensitivity;painful neuropathy;Pathway interactions;Patients;Peripheral;Peripheral nerve injury;Peripheral Nerves;pharmacologic;poor sleep;pre-clinical research;Reporting;response;Rodent;Sedation procedure;Sensory;Signal Transduction;Site;Sleep;Sleep Architecture;Sleep disturbances;Sleep Fragmentations;sleep quality;Spinal;spinal pathway;spontaneous pain;Stimulus;Symptoms;TACR1 gene;Techniques;Testing;Tetanus Toxin;Thermal Hyperalgesias;Transgenic Mice;Trauma;Trigeminal nerve structure

PROJECT_TITLE: Sleep fragmentation by brief awakenings as a surrogate to measure neuropathic spontaneous pain

STUDY_SECTION: NNRS

STUDY_SECTION_NAME: Neuroendocrinology, Neuroimmunology, Rhythms and Sleep Study Section[NNRS]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biomedical Imaging;Chronic Obstructive Pulmonary Disease;Clinical Research;Infant Mortality;Lung;Neonatal Respiratory Distress;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Pulmonary Hypertension;Rare Diseases

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

PHR: NARRATIVE  Advances in neonatal medicine have improved survival, particularly in infants born extremely premature, <30 weeks gestational age. However, the impact of extreme prematurity on heart and lung structure and function has not been rigorously assessed in young children. In this proposal, we will conduct the most in depth evaluation of changes in the heart and lung structure and function related to extreme preterm birth ever performed.

PI_NAMEs: HYSINGER, ERIK BRADFORD (contact);PARIKH, NEHAL A.;WOODS, JASON C

PROGRAM_OFFICER_NAME: NATARAJAN, ARUNA R

PROJECT_TERMS: 8 year old;Address;Admission activity;Adrenal Cortex Hormones;adverse outcome;Age;Air;Air Movements;Alveolar;antenatal;Asthma;Birth;Blood Vessels;Bronchopulmonary Dysplasia;burden of illness;Carbon Monoxide;Cardiac;Cardiopulmonary;Cessation of life;Child;Childhood;Chronic;Chronic Disease;Chronic Obstructive Pulmonary Disease;Clinical;clinically relevant;cohort;Data;Defect;Dexamethasone;Diffusion;Dose;early childhood;Early identification;early onset;Evaluation;extreme prematurity;Funding;Gases;Gestational Age;Goals;Growth;Health Care Costs;Heart;heart imaging;hospital readmission;Impairment;improved;Infant;Intervention;Life;Longitudinal cohort;Lung;Lung Diseases;lung imaging;Magnetic Resonance Imaging;Medical center;Medicine;Methods;Morphology;Neonatal;Neonatal Intensive Care Units;neurodevelopment;novel;Outcome;outcome prediction;Parents;Patient Readmission;Patients;Pediatric Hospitals;Pediatrics;Phenotype;Plethysmography;population based;postnatal;premature;Premature Birth;Premature Infant;Prevalence;prevent;Protons;pulmonary function;Pulmonary function tests;Pulmonary Hypertension;pulmonary vascular disorder;Questionnaires;recruit;Research;Resolution;Resources;respiratory;respiratory health;response;Risk;School-Age Population;secondary analysis;Severities;Severity of illness;Spirometry;Steroid therapy;Steroids;Structure;Subgroup;surfactant;Surfactant therapy;Symptoms;Three-Dimensional Image;Time;Tracheotomy procedure;United States;United States National Institutes of Health;ventilation;Work

PROJECT_TITLE: Trajectories of Regional Cardiopulmonary Structure and Function in A Longitudinal Cohort of Extremely Preterm Infants

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_CITY: LOS ANGELES

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: OVERALL PROJECT NARRATIVE Public Health Relevance: CCPR research increases scientific knowledge of population dynamics and their effects on reproductive and population health. Future improvements in public health require deeper understanding of the demographic and social determinants of health and, conversely, the effects of health on population dynamics and socioeconomic well- being. CCPR research seeks to understand these processes to improve public health.

PI_NAMEs: BAILEY, MARTHA JANE (contact)

PROGRAM_OFFICER_NAME: CLARK, REBECCA L

PROJECT_TERMS: Ally;Applications Grants;Applied Research;Area;Big Data;California;Case Study;Censuses;Child;Code;Collaborations;collaborative environment;Communities;Complex;Contraceptive Usage;cost effectiveness;Creativeness;Data;Data Collection;Data Science;Demography;Development;Discipline;Discrimination;Educational workshop;Environment;Extramural Activities;Faculty;Family;Family Demographies;Family member;Fertility;fundamental research;Funding;Future;Germination;Goals;Government Agencies;Grant;Health;health disparity;HIV/AIDS;Household;Immigration;improved;Inequality;Influentials;Infrastructure;innovation;Institution;Interdisciplinary Study;Internet;Investments;Knowledge;Los Angeles;medical schools;Mentors;Mentorship;Methodological Studies;Methodology;Methods;migration;mortality;National Institute of Child Health and Human Development;next generation;Nonprofit Organizations;novel;outreach;Personal Satisfaction;Pilot Projects;Play;Policies;Population;Population Dynamics;population health;Population Research;Population Sciences;Poverty;Preparation;Process;Productivity;programs;Public Health;public health relevance;Qualitative Methods;racism;Reproductive Health;Research;Research Methodology;Research Personnel;Research Project Grants;Resources;Role;Scientist;Secure;senior faculty;Services;social;social health determinants;Social Sciences;Societies;socioeconomics;Source;Statistical Methods;statistics;structural determinants;summer institute;Surveys;symposium;Time;United States National Institutes of Health;Universities;walkability;women's outcomes;Work;Writing

PROJECT_TITLE: California Center for Population Research (CCPR) at UCLA


PROJECT_TITLE: Administrative Core


ADMINISTERING_IC: DK

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_DEPT: PATHOLOGY

PHR: Project Narrative  Type 1 diabetes (T1D) is an autoimmune disease leading to major complications despite advancements in glucose monitoring and exogenous insulin. Adoptive cell therapy with polyclonal Tregs has been proven to be safe but lacks efficacy in preventing T1D progression after disease onset. This research seeks to improve adoptive Treg cell therapy by providing islet antigen specificity and homing to the germinal centers of pancreatic lymph nodes.

PI_NAMEs: THIRAWATANANOND, PUCHONG  (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Acceleration;Adoptive Cell Transfers;Adoptive Transfer;Affinity;Age;Animal Disease Models;Animal Model;Antigens;Autoantibodies;Autoimmune Diseases;Autoimmunity;Autologous;B-Cell Activation;B-Lymphocytes;Back;Beta Cell;Biological Models;BLR1 gene;Bystander Suppression;C-Peptide;cancer therapy;CD3 Antigens;CD4 Positive T Lymphocytes;Cell Separation;Cell Therapy;Cells;cellular engineering;Characteristics;chemokine receptor;Chemotaxis;Clinical Management;clinical translation;Confocal Microscopy;CXCL13 gene;cytokine;Data;Dendritic Cells;Dependence;Detection;Development;Diabetes Mellitus;Diabetes prevention;diabetogenic;Diagnosis;diphtheria toxin receptor;Disease Progression;early phase clinical trial;Educational process of instructing;efficacy evaluation;engineered T cells;Engineering;Enzyme-Linked Immunosorbent Assay;Exhibits;experience;Experimental Designs;Female;Florida;Flow Cytometry;Gene Transfer;Generations;Genes;Genome;genome editing;glucose monitor;Growth;Helper-Inducer T-Lymphocyte;Histology;Homing;Immune;immune activation;immune modulating agents;Immune response;Immune Targeting;Immunoglobulin Class Switching;Immunoglobulin Somatic Hypermutation;Immunology;immunoregulation;improved;In Vitro;in vitro testing;in vivo evaluation;Inbred BALB C Mice;Inbred NOD Mice;Incidence;Infusion procedures;Injections;Insulin;insulin secretion;Insulin-Dependent Diabetes Mellitus;insulitis;interleukin-21;Interruption;Investigational Therapies;islet;islet cell antibody;Islets of Langerhans;Knock-in;Location;lymph nodes;Mature B-Lymphocyte;Measures;Mediating;Mesentery;Methods;Migration Assay;Modality;Modeling;Mus;Onset of illness;Organ;Ovalbumin;Pancreas;Patients;Pharmaceutical Preparations;Phase;Phase I Clinical Trials;Physicians;Play;Population;pre-clinical;Prediabetes syndrome;prevent;Principal Investigator;Production;Prognosis;promoter;Protocols documentation;Rattus;Regulatory T-Lymphocyte;repaired;Reporting;Research;Research Design;Research Personnel;response;Risk;Role;Scientist;Serum;Site;skills;Specificity;Stains;Structure of beta Cell of islet;Structure of germinal center of lymph node;T cell infiltration;T-Cell Activation;T-Cell Receptor;T-Cell Receptor Genes;T-Lymphocyte;targeted treatment;Technical Expertise;Testing;Therapeutic;TNFSF5 gene;trafficking;Training;Transfusion;Transgenic Mice;Transgenic Organisms;Translating;Universities;Writing

PROJECT_TITLE: Generation of Islet Specific T Follicular Regulatory Like Cells for Autologous Cell Therapy of Type 1 Diabetes


NIH_SPENDING_CATS: Clinical Research

PI_NAMEs: HEUVELINE, PATRICK C. (contact)

PROJECT_TITLE: Development Core


NIH_SPENDING_CATS: Bioengineering;Data Science;Networking and Information Technology R&D (NITRD)

PI_NAMEs: BELTRAN-SANCHEZ, HIRAM  (contact)

PROJECT_TERMS: Archives;Big Data;California;Case Study;Communities;Computing Methodologies;Consult;Consultations;cost;Data;Data Collection;data dissemination;data enclave;data infrastructure;data integration;Data Science;Data Set;Data Storage and Retrieval;data visualization;Development;Educational workshop;Ensure;Environment;Event;Faculty;flexibility;frontier;Future;indexing;Infrastructure;innovation;Institution;Interdisciplinary Study;interest;Investments;Knowledge;Link;Methodological Studies;Methodology;Methods;Performance;Policies;Population;Population Dynamics;Population Research;Productivity;Records;Research;Research Infrastructure;Research Personnel;Research Project Grants;Resources;Scientist;Secure;Services;social media;Social Sciences;Speed;Statistical Methods;statistics;success;summer institute;symposium;Technical Expertise;Training

PROJECT_TITLE: Scientific and Technical Core


ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: Project Narrative Persistent HCV is a common cause of liver failure and death. There was limited effect of the only vaccine tested for prevention of HCV infection. We will define the successful immune responses observed in people infected with HCV many times who never become persistently infected and compare them to those seen in the only human vaccine efficacy trial and in vaccine models in order to design a more effective HCV vaccine.

PI_NAMEs: COX, ANDREA L (contact)

PROGRAM_OFFICER_NAME: GAUTAM, RAJEEV

PROJECT_TERMS: Acute;Acute Hepatitis C;acute infection;adaptive immune response;Adjuvant;Animals;anti-hepatitis C;Antibodies;Antibody Response;Antibody-mediated protection;Antigens;B cell repertoire;B-Lymphocytes;Binding;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cellular Immunity;Cessation of life;Characteristics;Chronic Hepatitis C;chronic infection;Clinical;clinical trial participant;Cohort Studies;Collaborations;Complex;Country;cross reactivity;Data;design;Development;efficacy study;efficacy trial;env Gene Products;Epitopes;Event;Evolution;Exposure to;Extinction;Future;Generations;Genes;Genetic;genome sequencing;Genotype;Goals;healthy volunteer;Hepatitis C;Hepatitis C Antibodies;Hepatitis C Therapy;Hepatitis C Transmission;Hepatitis C Vaccine;Hepatitis C virus;high risk;high risk population;Human;human data;Humoral Immunities;Immune;Immune response;Immunity;immunogenicity;Income;Infection;Length;Liver Failure;Mediating;Membrane;memory CD4 T lymphocyte;Modeling;Molecular;Mus;nanoparticle;neutralizing antibody;nonhuman primate;novel;novel vaccines;Participant;particle;Pathway interactions;Patients;Persons;Phenotype;Placebos;Plasma;Population;pre-clinical assessment;preclinical study;prevent;Prevention;Primary carcinoma of the liver cells;Primary Infection;programs;Property;Recovery;recruit;Regimen;repository;Research;Research Personnel;Resolution;Resources;response;Risk;Sequence Analysis;Site;Standardization;Structure;T cell response;T-Lymphocyte;Testing;Translating;transmission process;Vaccinated;Vaccination;vaccination strategy;Vaccine Antigen;vaccine candidate;vaccine development;vaccine efficacy;vaccine evaluation;vaccine failure;vaccine immunogenicity;vaccine platform;vaccine strategy;vaccine trial;Vaccinee;Vaccines;vector vaccine;Viral;Viral Antigens;Viral Genome;viral RNA;Viral Vector;Viremia;Virus;virus envelope;Virus-like particle;Work

PROJECT_TITLE: Mechanisms of spontaneous and vaccine mediated hepatitis C virus control to direct rational development of a novel HCV vaccine


NIH_SPENDING_CATS: Biotechnology;Digestive Diseases;Hepatitis;Hepatitis - C;Immunization;Infectious Diseases;Liver Disease;Prevention;Vaccine Related

PROJECT_TERMS: Adherence;Agreement;animal safety;Annual Reports;Award;Back;Budgets;central database;cohort;Collaborations;Communication;Communities;Coordination and Collaboration;Data;Data Analyses;data integrity;data management;data sharing;Development;Ensure;Environment;Fertilization;Fostering;Goals;Guidelines;Hepatitis C Vaccine;Hepatitis C virus;Human;human subject;Individual;Joints;Leadership;Legal patent;Location;Macaca;Manuscripts;Mediating;meetings;Methods;Mus;National Institute of Allergy and Infectious Disease;novel;operation;outreach;Plasma;Preparation;Privacy;Problem Solving;Productivity;programs;Progress Reports;Regulation;Reporting;Reproducibility;Research;Research Activity;Research Personnel;Research Project Grants;Resources;Role;Sampling;Science;Scientist;Secure;Serology test;Serum;Specimen;Structure;success;synergism;Travel;United States National Institutes of Health;Vaccine Research;Vaccines;Work


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Eczema / Atopic Dermatitis;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_DEPT: DERMATOLOGY

PHR: NARRATIVE Racial/ethnic disparities in atopic dermatitis (AD) outcomes among adults are understudied and remain unaddressed. This proposal aims to use a novel transdisciplinary approach to understand the contributions of individual behavioral, social, and environmental determinants of AD to racial/ethnic differences in AD outcomes among a socioeconomically disadvantaged, urban, adult population in North Philadelphia, Pennsylvania that is vulnerable to a high burden of skin disease. Knowledge gained from this project will inform the development and implementation of future interventions to eliminate racial/ethnic disparities in AD outcomes among adults who are living in similarly underserved, urban neighborhoods in the U.S.

PI_NAMEs: TAKESHITA, JUNKO  (contact)

PROGRAM_OFFICER_NAME: UNDALE, ANITA H

PROJECT_TERMS: Address;Adult;Affect;Air;Atopic Dermatitis;Behavior;Behavioral;Biology;Black race;burden of illness;Child;Childhood;Chronic Disease;chronic inflammatory disease;cohort;community intervention;Complex;contextual factors;Data;Dermatologist;design;Development;Diabetes Mellitus;Disease;Disease remission;Disparity;disparity elimination;Emotional;Environmental Epidemiology;Environmental Risk Factor;Epidemiology;ethnic difference;ethnic disparity;ethnic diversity;Ethnic Origin;Ethnic Population;experience;Future;future implementation;Genetic;Geographic Locations;Health;health care service utilization;health related quality of life;Heart Diseases;Hispanic;Housing;Hypertension;Impairment;improved;Individual;innovation;Intervention;Interview;Knowledge;Left;Lived experience;Longitudinal cohort;Longitudinal cohort study;Measures;Mediation;Mediator;Medical;medically underserved;medically underserved population;Methods;Modeling;Neighborhoods;novel;Outcome;Pennsylvania;Persons;Philadelphia;Population;Prevalence;psychosocial;Race;racial difference;racial disparity;racial diversity;Regimen;Reporting;Research Design;Research Methodology;Research Personnel;Role;Severities;Skin Care;skin disorder;Smoking History;social;social factors;Social support;socioeconomic disadvantage;Statistical Data Interpretation;Structure;Surveys;Urban Population;Work

PROJECT_TITLE: Atopic dermatitis in an urban adult population: identifying the role of social and environmental factors

STUDY_SECTION: HHD

STUDY_SECTION_NAME: Healthcare and Health Disparities Study Section[HHD]


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Digestive Diseases;Hepatitis;Hepatitis - C;Immunization;Infectious Diseases;Liver Disease;Prevention;Vaccine Related

PROJECT_TERMS: Acute;Acute Hepatitis C;acute infection;Aliquot;Animals;Antibodies;Antibody Response;Antibody titer measurement;Binding;Biological Assay;Biological Specimen Banks;Blood;Blood Component Removal;Cells;chronic infection;Clinical;clinical care;clinically relevant;Code;cohort;Collection;Counseling;design;Development;efficacy trial;Elements;Enrollment;Ensure;env Gene Products;Enzyme-Linked Immunosorbent Assay;Experimental Models;experimental study;Funding;Future;Genotype;Goals;Grant;Harm Reduction;Hepatitis C;Hepatitis C Acquisition;Hepatitis C Antibodies;Hepatitis C Incidence;Hepatitis C Vaccine;Hepatitis C virus;high risk;Human;Immune response;Immunity;immunogenicity;in vivo;Infection;infection risk;Infrastructure;Injecting drug user;injection drug use;Location;Lymphocyte;Macaca;Measurement;Measures;Mediating;Mediator;Monitor;Monoclonal Antibodies;Mus;Neutralization Tests;nonhuman primate;novel;Older Population;Outcome;outreach;Participant;Peripheral Blood Mononuclear Cell;Persons;Pharmacotherapy;Phase;Phylogenetic Analysis;Plasma;Population;Populations at Risk;prophylactic;prospective;Recovery;recruit;Recurrence;repository;Research;Research Personnel;Resources;response;Risk;RNA;Sampling;Scientist;screening;seroconversion;Serology test;Serum;Specimen;Standardization;success;Testing;Time;treatment program;United States National Institutes of Health;Vaccinated;Vaccination;vaccine candidate;vaccine evaluation;vaccine-induced antibodies;Vaccines;Viremia;Virus;Visit


ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE The trillions of microbes inhabit the human intestine (our microbiome) also change dramatically during the aging process. This application will study how gut microbiota changes with aging can cause inflammation leading to decline of health.

PI_NAMEs: DIXIT, VISHWA DEEP (contact);PALM, NOAH WOLCOTT

PROGRAM_OFFICER_NAME: TILAHUN, MULUALEM ENYEW

PROJECT_TERMS: 16S ribosomal RNA sequencing;Acceleration;Adipocytes;Adipose tissue;Age;aged;Aging;aging process;aging related;Antibiotic Therapy;Antibiotics;Antigens;B-Lymphocytes;Bacterial Translocation;Bacteroides thetaiotaomicron;Caloric Restriction;Cells;Chronic;Chronic Disease;commensal bacteria;conventional therapy;Coupled;Data;Development;dysbiosis;Enterococcus;experience;experimental study;Fatty acid glycerol esters;fly;Fucose;Funding;G-Protein-Coupled Receptors;Gene Expression Profile;Germ-Free;gut bacteria;gut microbes;gut microbiome;gut microbiota;hallmarks of aging;Health;healthspan;Homeostasis;Human;Impairment;Infection;Inflammaging;Inflammation;intestinal barrier;Intestines;Life;life span;Liver;lymph nodes;Lymphoid;Lymphoid Tissue;Macrophage;Mediating;member;Mesentery;Metabolic;Metabolic dysfunction;Microbe;microbial;microbiome;microbiota;Modeling;Monosaccharides;Mus;old mice;Omentum;pathogen;Play;prevent;Process;randomized, clinical trials;regenerative;response;restoration;Role;T-Lymphocyte;tertiary lymphoid organ;Testing;tissue injury;Visceral;Visceral fat

PROJECT_TITLE: Impact of dysbiosis on the development of age-related inflammation


ED_INST_TYPE: SCHOOLS OF EDUCATION

NIH_SPENDING_CATS: Aging;Arthritis;Bioengineering;Biomedical Imaging;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Osteoarthritis;Pain Research;Physical Activity;Physical Rehabilitation;Prevention;Rehabilitation

ORG_CITY: EAST LANSING

ORG_DEPT: MISCELLANEOUS

ORG_NAME: MICHIGAN STATE UNIVERSITY

PHR: PROJECT NARRATIVE For at least 1 in 3 young adults with an anterior cruciate ligament reconstruction, the injury and surgery are pivotal life events that lead to chronic pain, diminished long-term quality of life, and an increased risk for osteoarthritis. This study will determine how longitudinal changes in physical activity and walking biomechanics throughout the first year after surgery relate to poor symptomatic or osteoarthritis-related structural outcomes over the same period. This study is significant because it will provide foundational evidence for which patients and which visits to target with existing evidence-based interventions to mitigate the risk of poor outcomes following anterior cruciate ligament reconstruction.

PI_NAMEs: HARKEY, MATTHEW  (contact)

PROGRAM_OFFICER_NAME: WASHABAUGH, CHARLES H

PROJECT_TERMS: Accelerometer;adduct;anterior cruciate ligament injury;anterior cruciate ligament reconstruction;Atlases;biomechanical test;Biomechanics;Bone Spur;Cartilage;chronic pain;Classification;Clinical;clinical trial participant;Clinical Trials;Clinical Trials Design;Collaborations;Data Analyses;Degenerative polyarthritis;Development;Devices;Diagnosis;effusion;Event;evidence base;Evidence based intervention;Future;gait rehabilitation;Grant;high risk;improved;Injury;insight;joint loading;Joints;Knee;Knee Injuries;Knee Osteoarthritis;Laboratories;Lead;Level of Evidence;Life;Life Experience;Lifelong disability;Meniscus structure of joint;Mentors;modifiable risk;Monitor;Motion;novel;Operative Surgical Procedures;Outcome;Pain;Participant;Pathology;Patients;persistent symptom;Persons;Physical activity;Popliteal Cyst;Population;Predisposition;prevent;Quality of life;radiological imaging;Reaction;Reconstructive Surgical Procedures;recruit;Reporting;Research;Risk;Risk Factors;risk mitigation;skills;Sports Medicine;Standardization;Symptoms;Synovitis;System;Time;Training;trial planning;Ultrasonography;ultrasound;United States;Visit;Walking;Work;young adult

PROJECT_TITLE: Walk this Way: Physical Activity and Walking Biomechanics Lead to Early Knee OA Symptoms and Ultrasound-Detected Structural Pathology after ACL Reconstruction

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunotherapy;Ovarian Cancer;Prevention;Rare Diseases;Women's Health Research

ORG_CITY: HOUSTON

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: PROJECT NARRATIVE The omentum plays an important role in peritoneal immunity but also is the major site of ovarian cancer metastasis. Prophylactic removal of the omentum in ovarian cancer patients who do not present with overt metastasis has been contentious, and there are currently no effective strategies that prevent metastasis of occult circulating cancer cells to the omentum when this site is preserved. By using a preclinical model that recapitulates omental metastasis, this study will evaluate the ability of agents that inhibit a neutrophil response called neutrophil extracellular traps to boost anti-tumor immunity in the omentum and prevent omental metastasis.

PI_NAMEs: NAORA, HONAMI  (contact)

PROGRAM_OFFICER_NAME: CARDONE, MARCO

PROJECT_TERMS: Acceleration;Address;Adipose tissue;anti-PD1 therapy;Attention;B-Lymphocytes;cancer cell;Cancer Patient;cancer therapy;cancer type;Cells;Cellular Structures;chemotherapy;Chromatin Fiber;circulating cancer cell;Clinical;Clinical Management;cost effective;Data;Development;Disease;Disease Progression;Effectiveness;Excision;Exhibits;extracellular;Gene Modified;Goals;Greater sac of peritoneum;Immune;Immune Tolerance;Immunity;Immunosuppression;Immunotherapy;Implant;improved outcome;in vivo;Infection;inhibitor;innovation;insight;interest;Interleukin-10;Internet;Intestinal Obstruction;Laboratories;Lymphocyte;Malignant neoplasm of ovary;metastasis prevention;Modeling;Mus;Neoplasm Metastasis;neutrophil;novel strategies;Omentum;ovarian neoplasm;Pain;pathogen;Peritoneal;Peritoneal Fluid;permissiveness;Play;Positioning Attribute;Pre-Clinical Model;preservation;prevent;Prevention;Production;programmed cell death protein 1;prophylactic;Quality of life;Regimen;Regulatory T-Lymphocyte;Reporter;response;Risk;Role;Sepsis;Signal Transduction;Site;Spottings;standard of care;Stomach;Surface;T-Lymphocyte;targeted treatment;Th1 Cells;Therapeutic;therapy development;tumor;Tumor Immunity;tumor-immune system interactions;Underserved Population;Validation;Work

PROJECT_TITLE: Boosting anti-tumor immunity in the omentum for metastasis prevention


NIH_SPENDING_CATS: Biotechnology;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Genetics;Hepatitis;Hepatitis - C;Immunization;Infectious Diseases;Liver Disease;Prevention;Vaccine Related

PROJECT_TERMS: Acute;acute infection;Antibody Response;Antigens;Assessment tool;B-Lymphocytes;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;Cells;Characteristics;Chronic Hepatitis C;chronic infection;cohort;Data;Development;Disease Outcome;efficacy trial;Failure;Flow Cytometry;General Hospitals;Generations;Genetic Transcription;Genotype;Goals;healthy volunteer;Hepatitis C;Hepatitis C Vaccine;Hepatitis C virus;high dimensionality;high risk;Human;Immune;Immune response;Immunity;immunogenicity;Immunologics;Infection;Infection Control;Libraries;Massachusetts;Measures;Mediating;Memory;memory CD4 T lymphocyte;Metabolic;metabolic abnormality assessment;metabolic profile;Mus;nonhuman primate;novel;Outcome;Pan Genus;patient population;Patients;Peripheral Blood Mononuclear Cell;Persons;Phenotype;Placebos;Population;prevent;Primary Infection;programs;Property;prophylactic;Recovery;Regimen;response;Risk;RNA;Role;single-cell RNA sequencing;Specimen;T cell receptor repertoire sequencing;T cell response;T memory cell;T-Lymphocyte;Testing;Time;Transcriptional Regulation;Universities;Vaccination;vaccine candidate;Vaccine Design;vaccine response;vaccine strategy;Vaccines;Variant;Viral;Viremia;Virus

PROJECT_TITLE: Immunologic and Metabolic Profiles of T cells that control diverse HCV infections


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Genetics;Human Genome;Prevention;Social Determinants of Health

ORG_CITY: BLOOMINGTON

ORG_NAME: TRUSTEES OF INDIANA UNIVERSITY

ORG_STATE: IN

PHR: PROJECT NARRATIVE Due to the significant increase in the US elderly population and growing trend of younger cohorts having worse health outcomes, examining biological aging (e.g., epigenetic profiles) across the life course is a public health priority. There is substantial evidence linking social connectedness and aging-related morbidities, yet we know little about whether biological aging underlies the protective effects of social networks, or the strong mortality risk associated with social isolation. The proposed study will examine whether structural social network characteristics (i.e., stable social signatures) can slow or disrupt biological aging associated with DNA methylation, thereby promoting resilience to stress exposures, reducing healthcare costs, and increasing healthy years of life.

PI_NAMEs: PERRY, BREA LOUISE (contact)

PROGRAM_OFFICER_NAME: HOOKER, EMILY DIANE

PROJECT_TERMS: accelerated epigenetic aging;Acute;Address;adverse childhood events;Adverse effects;Affect;age acceleration;Aging;aging related;Alcohol consumption;Alzheimer's Disease;Alzheimer's disease related dementia;Area;Attention;Attenuated;Behavioral;Behavioral Mechanisms;Biological;biological age;Biological Aging;Biological Markers;Biological Process;cardiometabolism;Cardiovascular Diseases;Cells;Characteristics;Chronic;cohort;Complex;Data;data infrastructure;Dementia;density;Diabetes Mellitus;Discrimination;Disease;Disease Outcome;Divorce;DNA;DNA Methylation;early detection biomarkers;Elderly;Empirical Research;Environmental Exposure;epigenetic marker;Epigenetic Process;epigenome-wide association studies;Event;Exercise;Exhibits;experience;Exposure to;Family;food insecurity;Frequencies;Future;genomic locus;Goals;Health;health assessment;Health Care Costs;Health Surveys;healthy aging;Homeostasis;Household;Human;Human Development;Imprisonment;improved;Individual;Inflammation;innovation;Intervention;Interview;Knowledge;late life;Life;Life Cycle Stages;Link;Literature;member;Meta-Analysis;Methods;Methylation;middle age;Modeling;Morbidity - disease rate;mortality;mortality risk;neuropsychiatric disorder;novel;Obesity;obesity risk;Onset of illness;Pathogenesis;Pathogenicity;Pathway interactions;Pattern;Personal Satisfaction;Persons;Phenotype;Physiological;poor health outcome;Population;population health;Probability Samples;Process;promote resilience;Property;protective effect;public health priorities;Publishing;Reporting;Research;Research Infrastructure;Research Personnel;response;Risk;Risk Factors;Role;saliva sample;Salivary;Science;sedentary lifestyle;Site;Smoking;social;social implication;social influence;Social isolation;Social Network;social structure;Stress;stressor;Stroke;Structure;Time;Tissues;trend;United States National Institutes of Health;Variant

PROJECT_TITLE: Epigenetic mechanisms underlying the direct and moderating effects of social connectedness on complex diseases in aging

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: SALT LAKE CITY

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROGRAM NARRATIVE The CHEETAH Center for the Structural Biology of HIV Infection, Restriction and Viral Dynamics will be organized around: 1) three Scientific Projects that will advance our understanding of HIV-host interactions and provide the foundations for developing new therapeutic strategies for HIV treatment and cure, 2) three Scientific Cores that will advance and apply new technologies, 3) an Administrative Core that will coordinate Center activities and direct our Scientific Education, Public Outreach, and Molecular Animations, and 4) a Developmental Core that will engage and support the next generation of HIV structural biology researchers.

PI_NAMEs: SUNDQUIST, WESLEY I. (contact)

PROGRAM_OFFICER_NAME: MCDONALD, DAVID JOSEPH

PROJECT_TERMS: Animals;animation;Architecture;Award;base;Biological Products;Biology of HIV Infection;biophysical properties;Biopolymers;Capsid;career;Cells;Complex;CRISPR screen;Cryoelectron Microscopy;design;Development;Education;Electrons;Ensure;Fluorescence Spectroscopy;Foundations;Genome;Goals;HIV;HIV-1;Human Resources;Image;In Situ;Infection;Innate Immune Response;instrumentation;Life Cycle Stages;Link;member;Methodology;Molecular;Monitor;new technology;next generation;novel therapeutic intervention;Nuclear;Nucleosome Core Particle;outreach;Peptide Synthesis;Production;programs;Protein Engineering;protein purification;Proteins;Proviruses;reconstitution;Research Personnel;Resolution;Reverse Transcription;Role;scaffold;Science;screening;Signal Transduction;Site;structural biology;Structure;synergism;System;Technology;Tissues;tool;Training Activity;TRIM Gene;Viral;Viral Physiology;viral rebound;Virus;visiting scholar;web site;X-Ray Crystallography

PROJECT_TITLE: CHEETAH Center for the Structural Biology of HIV Infection, Restriction, and Viral Dynamics


NIH_SPENDING_CATS: HIV/AIDS;Infectious Diseases

PHR: CORE NARRATIVE Our Administrative Core will support CHEETAH Center missions by providing enabling administrative services that will increase the productivity, integration, efficiency and management of all of our Scientific Projects and Cores, and will maximize impact by supporting high-quality public outreach and scientific education programs.

PROJECT_TERMS: Administrator;AIDS prevention;animation;Award;Basic Science;Biology;Biology of HIV Infection;Budgets;Capital;Cells;Communication;Consultations;Cytoprotection;data sharing;Decision Making;Development;Education;education resources;Educational workshop;Equipment;Funding;Goals;HIV;HIV-1;Human Resources;Immune;Infection;Institution;interest;Learning;meetings;member;Mission;Molecular;National Institute of Allergy and Infectious Disease;new technology;next generation;Occupational activity of managing finances;outreach;Persons;Policies;Productivity;programs;Publications;Reagent;recruit;Reproducibility;Research;Research Personnel;Science;Services;structural biology;Structure;success;symposium;System;Training;Utah;Viral;Virginia;Visualization;web site


PHR: CORE NARRATIVE Our Developmental Core will engage, train, and support the next generation of HIV researchers by providing Collaborative Development Awards to talented young independent researchers, running a journal club-style Seminar Series in which Center trainees will present current HIV-1 research papers, offering a Visiting Scholar Program for Center trainees that will include online training and lab visits to gain “hands on” experience and expert guidance, and providing Other Training Activities that will include visual communication workshops for Center trainees.

PROJECT_TERMS: Agreement;animation;Award;Binding;Biology of HIV Infection;Biophysics;Communication;design;Development;Educational process of instructing;Educational workshop;experience;Funding;HIV;HIV-1;interest;Journals;Laboratories;Learning;Literature;member;Methods;next generation;outreach;Paper;posters;Program Development;programs;Public Health Education;Reporting;Research;Research Personnel;Research Project Grants;Resources;Running;Scholars Program;Scientific Advances and Accomplishments;Series;Site;skills;structural biology;Talents;Technology;Training;Training Activity;training opportunity;Training Programs;Travel;Viral;virtual;Visit;visiting scholar;Visual


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Bioengineering;Emerging Infectious Diseases;Infectious Diseases;Kidney Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pediatric;Precision Medicine

ORG_NAME: CHILDREN'S HOSPITAL OF LOS ANGELES

PHR: Drugs are currently prescribed to groups of patients (e.g., children) with fixed dosing in each population for the duration of therapy, which results in wide variations in blood drug concentrations between patients and within a patient over time. Our group is uniquely qualified to conduct translational work that combines sophis- ticated machine learning with traditional population drug models and novel laboratory infection models. We will use these capabilities and the VPICU dataset of >20,000 critically ill children to deliver software tools that predict changes in renal function in these patients, that predict changes in drug kinetics over time in patients using vancomycin as an example, and that quantify the degree of within-patient variability in vancomycin con- centrations that is relevant to laboratory kill in our hollow fiber infection model of Staphylococcus aureus, a common and serious bacterial infection in hospitalized children.

PI_NAMEs: NEELY, MICHAEL N. (contact)

PROGRAM_OFFICER_NAME: SAMEDY BATES, LESLY

PROJECT_TERMS: Accounting;Acute Renal Failure with Renal Papillary Necrosis;Admission activity;adverse drug reaction;Algorithms;Anti-Bacterial Agents;Antibiotics;Bacteremia;Bacterial Infections;Blood;Categories;Cefazolin;Characteristics;Child;Childhood;Clindamycin;Clinical;clinically relevant;Collection;Compensation;Computer software;Computing Methodologies;Creatinine;Creatinine clearance measurement;Critical Illness;Critically ill children;Data Set;Differential Equation;Dose;Drug Design;drug development;Drug Exposure;Drug Kinetics;Drug Modelings;Drug Monitoring;Drug Prescriptions;Drug Targeting;Excretory function;FDA approved;Fiber;Future;Genus staphylococcus;Hospitalized Child;Hospitals;improved;In Vitro;Individual;Individuality;individualized medicine;Infection;innovation;inter-individual variation;Kidney;Kidney Failure;Laboratories;Laboratory Infection;Learning;Link;Machine Learning;mathematical methods;Measurement;Measures;Methicillin Resistance;methicillin resistant Staphylococcus aureus;methicillin susceptible Staphylococcus aureus;Methods;Modeling;novel;novel strategies;Obstetric pharmacology;off-label use;Organism;Outcome;outcome prediction;patient variability;Patients;Pediatric Intensive Care Units;pediatric pharmacology;Pharmaceutical Preparations;pharmacodynamic model;Pharmacodynamics;pharmacokinetics and pharmacodynamics;Plasma;Population;population based;predictive modeling;predictive tools;Predisposition;Probability;Process;Qualifying;Recording of previous events;recurrent neural network;Regimen;Renal function;Sepsis;Series;Serum;severe injury;Software Tools;Staphylococcus aureus;Statistical Methods;Testing;Therapeutic;therapy duration;Time;tool;Toxic effect;Training;Translational Research;United States;Vancomycin;Variant;virtual;Voriconazole;Weight;Work

PROJECT_TITLE: Precision Dosing for Critically Ill Children


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics;HIV/AIDS;Human Genome;Infectious Diseases;Machine Learning and Artificial Intelligence

PHR: CORE NARRATIVE This Core will provide CHEETAH Center members with advanced capabilities for synthesizing new peptides, designing new proteins, and discovering and characterizing new factors involved in HIV-host interactions. Applications of these advancing technologies will enable new approaches and insights into many of the problems under study in our Center.

PI_NAMEs: KAY, MICHAEL S (contact)

PROJECT_TERMS: Amino Acids;base editing;Biochemical;Biology of HIV Infection;Biopolymers;candidate identification;Cell Line;Cells;chemical synthesis;Chemicals;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Complex;CRISPR library;CRISPR screen;CRISPR/Cas technology;crosslink;Custom;deep learning;design;Development;Epitopes;experimental study;fluorophore;functional genomics;Genes;Genomic approach;Goals;Hand;HIV;HIV-1;Image;improved;Infection;insight;instrumentation;Integration Host Factors;interest;Investigation;Isotopes;Label;Laboratories;Length;Lentivirus Vector;Libraries;Ligation;Link;machine learning model;member;method development;Methodology;Methods;Methylation;Modification;Mutation;mutation screening;novel;novel strategies;peptide chemical synthesis;Peptide Synthesis;Peptides;Periodicity;Phase;Phenotype;Phosphorylation;polypeptide;Protein Engineering;protein expression;protein structure;Proteins;Reagent;Recombinants;Research;Role;screening;SETDB1 gene;Solid;Solubility;structural biology;synthetic peptide;synthetic protein;System;Technology;tool;TRIM Gene;Validation;validation studies;Viral


NIH_SPENDING_CATS: Biotechnology;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Hepatitis;Hepatitis - C;Immunization;Infectious Diseases;Liver Disease;Prevention;Vaccine Related

PI_NAMEs: BAILEY, JUSTIN RICHARD (contact)

PROJECT_TERMS: adaptive immunity;Affinity;Animal Model;Antibodies;Antibody Response;Antibody titer measurement;Antigenic Variation;Antigens;Autologous;Automobile Driving;B cell repertoire;B-Cell Activation;B-cell receptor repertoire sequencing;B-Lymphocytes;Binding;Binding Sites;Biological Assay;Blocking Antibodies;CD4 Positive T Lymphocytes;CD81 gene;Cells;Chronic;chronic infection;Clone Cells;Collaborations;Complex;Development;Disease Outcome;env Gene Products;Epitopes;Evolution;Exposure to;Flow Cytometry;Functional disorder;Hepatitis C;Hepatitis C Antibodies;Hepatitis C Vaccine;Hepatitis C virus;high dimensionality;HIV-1;Human;human subject;Immune;Immune response;Immunoglobulin Somatic Hypermutation;In Vitro;in vivo;Individual;Infection;Infusion procedures;Link;Measures;Mediating;Modeling;Monoclonal Antibodies;neutralizing antibody;novel;Participant;Phenotype;Plasma;Play;pressure;Primary Infection;Probability;Proteins;Resistance;response;Role;single-cell RNA sequencing;Site;Stimulus;Study Subject;T cell response;T-Lymphocyte;Testing;Time;vaccine candidate;vaccine development;vaccine response;Vaccines;Variant;Viral;Viral Physiology;Viremia;Virus;Virus Diseases;Work

PROJECT_TITLE: Mechanisms of antibody-mediated control of repeated hepatitis C virus infection in humans


PHR: CORE NARRATIVE This Core will enable CHEETAH investigators to visualize and follow the behavior of HIV-related complexes by using fluorescence spectroscopy to analyze structure and dynamics, antibody technology to facilitate 3D structure determinations, and electron cryotomography to visualize complexes in their native cellular environments.

PI_NAMEs: PUGLISI, JOSEPH D (contact)

PROJECT_TERMS: Antibodies;antibody mimetics;Behavior;Binding;Biological;Biological Process;biological systems;Biology of HIV Infection;Complex;Cryoelectron Microscopy;design;Electron energy loss spectroscopy;Electron Microscopy;Electrons;empowerment;Environment;Epitopes;Fluorescence;Fluorescence Spectroscopy;HIV;HIV-1;Hybrids;Image;imaging approach;instrumentation;Investigation;Ions;Label;light microscopy;Link;Macromolecular Complexes;Measures;member;Methodology;Methods;Microscopy;Molecular;Molecular Conformation;Nanotechnology;novel;novel strategies;particle;protein complex;Proteins;Reporter;Research Personnel;Resolution;RNA;RNA I;scaffold;single molecule;Site;spectroscopic imaging;Spectrum Analysis;structural biology;Structure;System;Technology;three dimensional structure;Time;tool;trafficking;Viral;Virus;Visualization;waveguide


NIH_SPENDING_CATS: Cancer;Genetics

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: Project Narrative DNA double strand breaks are a dangerous, yet common form of DNA damage and their repair is essential for cell survival. In humans, two major pathways rejoin broken chromosomes and the improper utilization of these pathways is associated with the onset of cancer. Using advanced single-molecule imaging in a physiological cell-free extract, this proposal will elucidate the mechanisms by which DNA double strand break repair pathways are selected.

PI_NAMEs: LOPARO, JOSEPH J. (contact)

PROGRAM_OFFICER_NAME: WITKIN, KEREN L

PROJECT_TERMS: Address;Back;Binding;Biochemical;Biological;Biological Assay;Biological Process;C-terminal;cancer cell;cancer therapy;Cell Death;Cell Survival;Cells;Chromosomal Breaks;Chromosomal Rearrangement;Chromosomal translocation;Chromosome Pairing;clinically relevant;cofactor;Dangerousness;Data;Decision Making;DNA;DNA Binding;DNA Damage;DNA Double Strand Break;DNA Ligation;DNA Repair Pathway;Double Strand Break Repair;egg;Enzymes;Equilibrium;Eukaryotic Cell;Excision;experimental study;Filament;Genes;genetic approach;Glues;Health;helicase;homologous recombination;Human;Image;imaging approach;Individual;insertion/deletion mutation;insight;Invaded;Knowledge;Label;Ligation;Malignant Neoplasms;Mastication;Mediating;Molecular;molecular imaging;N-terminal;Nonhomologous DNA End Joining;novel;Nucleoproteins;Nucleotides;Pathway interactions;Physiological;Play;Polymerase;Process;Proteins;Rad51 recombinase;Rana;Reaction;reconstitution;Regulation;repaired;Resected;response;Role;Signal Transduction;single molecule;Single-Stranded DNA;Sister Chromatid;Site;Synapses;System;targeted cancer therapy;Time;trait;tumorigenesis;Work;Xenopus;Xenopus laevis

PROJECT_TITLE: Molecular mechanisms of pathway choice in DNA double strand break repair

STUDY_SECTION: MSFC

STUDY_SECTION_NAME: Macromolecular Structure and Function C Study Section[MSFC]


PHR: CORE NARRATIVE This Core will provide access to state-of-the-art instrumentation and expertise in construct design, protein expression, biophysical characterization, X-ray crystallography, cryoEM, and training in biophysics and structural biology.

PI_NAMEs: HILL, CHRISTOPHER P. (contact)

PROJECT_TERMS: analytical ultracentrifugation;Bacterial Proteins;Binding;Biochemistry;Biological Assay;Biology;Biology of HIV Infection;biophysical properties;Biophysics;Calorimetry;Circular Dichroism;Collaborations;Complement;Complex;Computer software;computerized data processing;Cryoelectron Microscopy;Crystallization;Data;Data Collection;design;design and construction;Development;Experimental Designs;Fluorescence Polarization;Foundations;Growth;HIV;HIV-1;insight;instrumentation;Kinetics;Laboratories;macromolecule;member;Micro Electron Diffraction;Negative Staining;novel therapeutic intervention;particle;Process;Production;programs;protein expression;protein folding;protein purification;Proteins;Recombinants;Recording of previous events;Resolution;Resources;RNA;Robotics;Roentgen Rays;Role;Sampling;Scholars Program;screening;Services;small molecule;structural biology;Structure;success;Surface Plasmon Resonance;Synchrotrons;System;Techniques;Thermodynamics;Titrations;tool;Training;Universities;Utah;Validation;Viral;visiting scholar;X-Ray Crystallography


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: We are applying to continue a successful interdisciplinary pre-doctoral training program focused on Environmental Epidemiology in Community Settings within the Department of Environmental Health at the Boston University School of Public Health. We will recruit four pre-doctoral trainees each year for a steady state census of twelve trainees. This proposal describes a specific training regimen that is designed to prepare pre-doctoral students to use the most sophisticated methods available to advance the state of knowledge and develop new methods in community-oriented environmental epidemiology.

PI_NAMEs: CLAUS HENN, BIRGIT GUNHILD (contact)

PROGRAM_OFFICER_NAME: SHREFFLER, CAROL A


ORG_NAME: WRIGHT STATE UNIVERSITY

PHR: PROJECT NARRATIVE Despite many anti-hypertensive drugs, up to 90% of chronic kidney disease (CKD) patients exhibit uncontrolled hypertension, which accelerates kidney damage and kidney function decline. In fact, CKD is the strongest predictor of treatment-resistant hypertension, and worse, an alarming 96% of those with early, asymptomatic CKD are unaware of their condition. The proposed work will identify novel strategies to combat the detrimental cycle of hypertension and kidney damage in early and late stages, and is thus highly relevant to public health.

PI_NAMEs: WILLIAMS, CLINTORIA RICHARDS (contact)

PROGRAM_OFFICER_NAME: NIHALANI, DEEPAK

PROJECT_TERMS: absorption;Acceleration;Anti-Hypertensive Agents;Attenuated;Biological Availability;Blood Pressure;blood pressure elevation;blood pressure regulation;Calcineurin inhibitor;Carrier Proteins;Cells;Chronic Kidney Failure;combat;Data;Development;Diabetes Mellitus;Diabetic Nephropathy;Diagnosis;Diet;disease model;Disease Progression;Distal convoluted renal tubule structure;Early Intervention;efficacy evaluation;epithelial Na+ channel;Equilibrium;Excretory function;Exhibits;FDA approved;Goals;Health;Homeostasis;Hydroxychloroquine;Hypertension;Impairment;In Vitro;inhibitor;insight;Intervention;Ionophores;Kidney;Knowledge;Link;Maintenance;Modeling;Molecular;mouse model;Mus;novel;novel strategies;novel therapeutic intervention;Nuclear;Outcome;Pathway interactions;Patients;Physiological;Plasma;Populations at Risk;preclinical study;Prediction of Response to Therapy;prevent;Property;Public Health;Publishing;renal damage;Renal function;Renal Hypertension;Reporting;Resistant Hypertension;Role;Signal Transduction;Signaling Molecule;SLC12A3 gene;Testing;Therapeutic;Therapeutic Effect;Translations;Transplant Recipients;urinary;Urine;wasting;Work;Zinc deficiency;Zinc supplementation

PROJECT_TITLE: Mechanisms of the Renoprotective Properties of Zinc Supplementation in Mouse Models of Chronic Kidney Disease

STUDY_SECTION: IVPP

STUDY_SECTION_NAME: Integrative Vascular Physiology and Pathology Study Section[IVPP]


NIH_SPENDING_CATS: Genetics;HIV/AIDS;Infectious Diseases

PHR: PROJECT NARRATIVE To establish a productive infection, HIV-1 must enter the cell, copy its RNA genome into DNA, enter the nucleus, and integrate into the host cell DNA. Studies in this Project will uncover currently unknown aspects of these different processes in molecular detail, providing a foundation for the identification and development of new anti-viral targets. We will also characterize how the potent new HIV-1 inhibitor, lenacapavir, binds the viral capsid and inhibits nuclear entry.

PI_NAMEs: BJORKMAN, PAMELA J (contact)

PROJECT_TERMS: 3-Dimensional;Architecture;Binding;Biological Assay;Biology of HIV Infection;Capsid;Cell Communication;Cell membrane;Cell Nucleus;Cell-Free System;Cells;Chromatin;Complementary DNA;Complex;Coupled;design;Development;dimer;DNA;DNA Integration;Docking;electron tomography;Electrons;experimental study;Exposure to;Fluorescence Microscopy;Foundations;Genome;genomic RNA;HIV-1;Host Factor 1 Protein;Image;In Situ;in vivo;Infection;inhibitor;Integration Host Factors;Knowledge;Learning;Life Cycle Stages;Macaca;Methods;Molecular;Molecular Conformation;novel;Nuclear;Nuclear Import;Nuclear Pore;Nucleosome Core Particle;Pathway interactions;Plastic Embedding;Process;Productivity;Proviruses;receptor;reconstitution;Replication Initiation;Resolution;Reverse Transcription;RNA;Role;Series;simian human immunodeficiency virus;Stains;structural biology;Structure;System;Systems Integration;Time;Tissue Sample;Transcription Initiation;transcriptional coactivator p75;Ubiquitin;Viral;viral DNA;viral genomics;Viral Reverse Transcription;viral RNA;Virus;Virus Integration;Visualization


NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Conditions Affecting the Embryonic and Fetal Periods;Mucopolysaccharidoses (MPS);Neurosciences;Orphan Drug;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Rare Diseases

ORG_CITY: SAN FRANCISCO

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative Patients with lysosomal storage disorders can be treated with enzyme replacement therapies (ERT) but many patients already have signs of the disease by the time they start treatment and may develop immune reactions to ERT. We are conducting a phase 1 clinical trial of in utero ERT in fetuses with several types of lysosomal storage disorders to evaluate the safety and efficacy of this approach in improving long-term outcomes including neurologic and cardiac function, mobility, and growth; we will also analyze pharmacokinetics and pharmacodynamics of in utero ERT and the ability to induce tolerance to the missing enzyme.

PI_NAMEs: MACKENZIE, TIPPI  (contact)

PROGRAM_OFFICER_NAME: REN, ZHAOXIA

PROJECT_TERMS: Address;Affect;Antibodies;Antibody Therapy;Attitude;Back;Biochemical;Birth;Blood;Blood Transfusion;blood-brain barrier crossing;blood-brain barrier penetration;Brain;Cardiac;Cardiomyopathies;Child;Clinical Trials;Collaborations;Data;design;Development;Diagnosis;Disease;disease prognosis;Edema;Education;effective therapy;Enrollment;Ensure;Enzyme Induction;enzyme replacement therapy;Enzymes;exome sequencing;experience;Exposure to;Family;FDA approved;fetal;Fetal safety;Fetus;first-in-human;Functional disorder;Funding;Future;Generations;Genetic;genetic testing;Genotype;Glycogen storage disease type II;Glycosaminoglycans;Goals;Growth;heart function;Hydrops Fetalis;Immune;Immune response;immunoreaction;improved;improved outcome;in utero;Incidence;Individual;infancy;Infrastructure;Infusion procedures;Injections;International;Investigational Drugs;Live Birth;Lysosomal Storage Diseases;maternal safety;Measures;Medical;Microglia;mouse model;Mucopolysaccharidoses;Mucopolysaccharidosis VII;multidisciplinary;multiorgan damage;Mus;Mutation;Nervous System Physiology;Nervous System Trauma;Neurocognitive Deficit;Neurologic Effect;New Drug Approvals;Organ;organ growth;Outcome;Parents;Pathology;patient advocacy group;Patient Participation;Patients;pediatric patients;Penetration;Perinatal;perinatal morbidity;Perinatal mortality demographics;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;phase 1 study;Phase I Clinical Trials;Phenotype;postnatal;Pregnancy;Pregnant Women;prenatal;prenatal exposure;prenatal therapy;prevent;programs;Progressive Disease;Proteins;Protocols documentation;Publishing;Recombinants;Recording of previous events;Regulatory T-Lymphocyte;Respondent;Risk;Safety;safety and feasibility;Severities;Siblings;Site;skeletal dysplasia;specific biomarkers;success;Surveys;Techniques;Testing;Time;treatment center;trial design;ultrasound;Umbilical vein;Wolman Disease

PROJECT_TITLE: Phase 1 Study of In Utero Enzyme Replacement Therapy for the Treatment of Lysosomal Storage Diseases


PHR: PROJECT NARRATIVE Although the virus eventually wins in the absence of sustained antiretroviral treatment (ART), humans have an array of innate immune responses that help to limit HIV-1 replication, particularly during viral transmission and when the virus rebounds upon removal of ART. These observations imply that it might be possible to devise effective new antiviral therapeutic strategies if we better understood how innate immune factors sense and inhibit viral replication, and can learn better how to manipulate and harness these responses. The primary goal of this Project is therefore to gain such insights into innate immune factors that act at early steps in the HIV life cycle.

PI_NAMEs: PORNILLOS, OWEN  (contact)

PROJECT_TERMS: Affect;Anti-viral Agents;Anti-viral Response;antiretroviral therapy;APOCEC3G gene;Binding;Biological Assay;Biology of HIV Infection;Capsid;Cell-Free System;Cells;cofactor;Cryoelectron Microscopy;design;Detection;Dissociation;Excision;experimental study;Genetic;Goals;HIV;HIV-1;HIV/AIDS;Human;Immune;Immunologic Factors;In Vitro;Infection;inhibitor;Innate Immune Response;innate immune sensing;insight;Integration Host Factors;Interferons;Interruption;Learning;Life Cycle Stages;Lipid Bilayers;Lipids;Mediating;Membrane Fusion;Modeling;Molecular Conformation;Myeloid Cells;novel;Pathway interactions;phospholipid scramblase;pressure;Process;Proteins;Reaction;Recombinants;reconstitution;Regulation;response;Reverse Transcription;Role;Running;sensor;Serine;Signal Transduction;structural biology;Structure;System;Testing;Therapeutic;Transcript;transmission process;TRIM Gene;TRIM5 gene;Ubiquitination;Viral;Viral Physiology;viral rebound;viral transmission;Virion;Virus;Virus Replication


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Biotechnology;Cancer;Digestive Diseases;Immunization;Immunotherapy;Orphan Drug;Pancreatic Cancer;Rare Diseases

ORG_CITY: NEW YORK

ORG_DEPT: GENETICS

ORG_NAME: ROCKEFELLER UNIVERSITY

ORG_STATE: NY

PHR: Project Narrative To make immunotherapy for cancer more efficient, we aim to target macrophages within the tumor microenvironment and recruit them to fight the tumor. Using antibodies against specific pattern recognition receptors on macrophages we can increase efficacy of T cell mediated targeting and provide better therapeutic benefits also against so far unresponsive tumors.

PI_NAMEs: KARLSSON, MIKAEL  ;RAVETCH, JEFFREY VICTOR (contact)

PROGRAM_OFFICER_NAME: SINGH, ANJU

PROJECT_TERMS: Agonist;Anti-CD40;Antibodies;antibody engineering;Antibody Therapy;Antigen Presentation;Antitumor Response;Binding;Biological Assay;Blocking Antibodies;cancer immunotherapy;cancer therapy;CD8-Positive T-Lymphocytes;cell killing;Cells;checkpoint therapy;Chemotherapy and/or radiation;Clinical;Clinical Treatment;Clinical Trials;Combined Modality Therapy;CTLA4 gene;Cytotoxic T-Lymphocytes;Data;design;Development;Disease;Dose;Engineering;Evaluation;exhaustion;Fc Receptor;fighting;Flow Cytometry;Genetically Engineered Mouse;Goals;Human;IgG Receptors;Immune;Immune system;Immunoglobulin G;immunoregulation;immunosuppressive macrophages;Immunotherapeutic agent;Immunotherapy;improved;in vitro Assay;in vivo;in vivo evaluation;Inflammatory;innovation;Innovative Therapy;interest;Interleukin-12;Knowledge;Lead;Macrophage;Malignant neoplasm of pancreas;Malignant Neoplasms;Mediating;member;Methods;Mus;Myelogenous;Myeloid Cells;Myeloid-derived suppressor cells;Natural Killer Cells;Neoplasm Metastasis;neoplastic cell;new therapeutic target;novel;Oncology;Operative Surgical Procedures;Pancreas;Pancreatic Adenocarcinoma;pancreatic cancer model;pancreatic cancer patients;pancreatic neoplasm;Pathway interactions;Pattern recognition receptor;PD-1/PD-L1;Phenotype;prevent;Property;Proteins;receptor;receptor binding;recruit;Research;Research Personnel;response;Role;Signal Transduction;Specimen;standard of care;Structure;success;T cell therapy;T-Lymphocyte;targeted treatment;Testing;Therapeutic;therapeutic candidate;TNF gene;TNFRSF5 gene;translational potential;Treatment Efficacy;tumor;Tumor Antigens;Tumor Immunity;tumor microenvironment;Tumor-associated macrophages;tumor-immune system interactions;Variant;Work

PROJECT_TITLE: Engaging immunosuppressive myeloid cells in the TME for the treatment of pancreatic cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-M(08)F]


NIH_SPENDING_CATS: Biotechnology;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Hepatitis;Hepatitis - C;Immunization;Infectious Diseases;Liver Disease;Prevention;Vaccine Related

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PROJECT_TERMS: Adenoviruses;Animals;Anti-viral Agents;Antibodies;Antibody Avidity;Antibody Response;antigen binding;Antigens;B-Lymphocytes;Binding;Binding Sites;Biological Assay;Chronic;Chronic Hepatitis C;Complex;cost;cross reactivity;Cryo-electron tomography;design;Development;env Gene Products;Environment;Enzyme-Linked Immunosorbent Assay;Epidemic;epidemic response;epidemic virus;Epitopes;Genes;Genetic Variation;Germ Lines;Hepatitis C;Hepatitis C Vaccine;Hepatitis C virus;hepatitis C virus envelope 2 protein;Human;Immune response;Immunization;Immunize;immunogenic;immunogenicity;improved;In Vitro;Individual;Infection;Length;Liver Cirrhosis;Liver diseases;lonely individuals;Macaca;Mediating;Membrane;Methods;Molecular Conformation;mosaic;Mus;nanoparticle;neutralizing antibody;nonhuman primate;novel;novel vaccines;Orthologous Gene;Pan Genus;Persons;Point Mutation;preservation;Preventive vaccine;Primary carcinoma of the liver cells;Production;Proteins;receptor binding;Research Project Grants;Resolution;response;Sampling;Serum;Sorting;structural determinants;Structure;T cell response;T-Lymphocyte;Testing;three dimensional structure;Vaccinated;Vaccination;vaccination strategy;vaccine candidate;vaccine development;vaccine trial;Vaccines;Variant;Virion;Virus;Virus Diseases;Virus-like particle;Work

PROJECT_TITLE: Characterization of HCV vaccine induced-neutralizing antibody response in non-human primates


PHR: PROJECT NARRATIVE Research in this Project is designed to create the foundations necessary for developing treatments that could cure HIV patients, broadly protect animals against infection by enveloped viruses, and deliver biological therapeutics more effectively.

PI_NAMEs: MOTHES, WALTHER H (contact)

PROJECT_TERMS: Animal Model;Animals;Anti-Retroviral Agents;Anti-viral Agents;Architecture;Binding;Binding Sites;Biological;Biological Products;Biological Response Modifier Therapy;Biology;Biology of HIV Infection;Capsid;cell behavior;Cell Line;cell type;Cells;Collaborations;Complex;delivery vehicle;design;Development;Engineering;flexibility;Foundations;frontier;Gene Expression Profile;gene therapy;Generations;Genes;Goals;Heterochromatin;HIV;HIV-1;humanized mouse;Image;imaging approach;In Situ;Infection;Integral Membrane Protein;Knock-in;Knock-in Mouse;Knockout Mice;macromolecule;Medicine;Membrane;Membrane Fusion;Messenger RNA;Methods;Methyltransferase;Modeling;Molecular;Molecular Structure;Mouse Cell Line;mouse model;Mus;nanocage;nanomaterials;nanoparticle;new technology;next generation;nonhuman primate;particle;Pathway interactions;Patients;Protein Engineering;Proteins;receptor;recruit;Research;Resistance;Resolution;Scaffolding Protein;self assembly;SETDB1 gene;Shapes;Site;SIV;structural biology;Structure;success;System;technology platform;Testing;Therapeutic;Therapeutic Intervention;Transgenic Mice;Viral;viral rebound;Virus;Virus Diseases;Visualization


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

PHR: Narrative: Bridge2AI Center The promise of using Big Data for precision medicine, drug discovery, and a host of other challenges has remained elusive; barriers to effectively leveraging Artificial Intelligence (AI) and Machine Learning (ML) are both serious and varied — occurring at every stage of the development lifecycle from data to standards to tools and algorithms. Our Bridge to AI Center will engage the scientific community across this lifecycle in order to ensure that data are ethically sourced, machine-understandable, and easily integrated with other data. These advances will catalyze AI solutions to complex biomedical challenges.

PI_NAMEs: MUNOZ-TORRES, MONICA CECILIA (contact)

PROGRAM_OFFICER_NAME: SEN, SHURJO KUMAR

PROJECT_TERMS: Acceleration;Address;Adoption;Algorithms;Artificial Intelligence;artificial intelligence algorithm;Behavioral;behavioral health;Behavioral Research;Benchmarking;Big Data;Biomedical Research;Bridge to Artificial Intelligence;Collaborations;Communities;community based evaluation;community building;Community Developments;community engagement;community setting;Complement;Complex;Data;data resource;Data Set;data sharing;Dedications;design;Development;drug discovery;Educational Curriculum;empowerment;Engineering;Ensure;Environment;Ethics;Evaluation;evidence base;experience;Fostering;Funding;Future;Generations;Goals;Health;Human;improved;Incentives;indexing;innovation;Knowledge;Language;Learning;Life Cycle Stages;Machine Learning;Metadata;Methodology;Mind;Mission;novel;Outcome;Participant;Persons;Positioning Attribute;precision medicine;Process;Productivity;programs;Readiness;recruit;Research;Research Personnel;responsible artificial intelligence;Science;skill acquisition;skills;social;Societies;Sociology;Source;Standardization;Structure;Technology;tool;Training;Training Programs;translational pipeline;Trust;trustworthiness;United States National Institutes of Health;Vision;Vocabulary;Work;Workforce Development

PROJECT_TITLE: Integration, Dissemination and Evaluation(BRIDGE) Center for the NIH Bridge to Artificial Intelligence (BRIDGE2AI) Program


ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE Nearly half of American adults have hypertension, a known risk factor for severe complications that can reduce life quality or lead to death. We need to understand more of the mechanisms of hypertension to develop new anti-hypertensive therapies. The proposed research will address this serious public health concern by providing fundamental knowledge on the role of prostaglandin EP4 receptors in the development of hypertension.

PI_NAMEs: YANG, TING  (contact)

PROGRAM_OFFICER_NAME: KETCHUM, CHRISTIAN J

PROJECT_TERMS: absorption;Adult;Affect;American;Amiloride;antagonist;Anti-Hypertensive Agents;Area;Attenuated;Blood Pressure;blood pressure control;blood pressure elevation;blood pressure reduction;candidate identification;cardiovascular effects;Cells;cellular targeting;Cessation of life;Chronic Disease;Clinical Research;Complex;Cyclic AMP;Development;Dinoprostone;Diuretics;Drug Receptors;Duct (organ) structure;Ductal Epithelium;Electrophysiology (science);Endothelial Cells;EP4 receptor;epithelial Na+ channel;Epithelium;Essential Hypertension;Excision;Excretory function;genetic approach;Goals;Homeostasis;Human;Hypertension;hypertensive;Individual;inhibitor;Intercalated Cell;Kidney;kidney epithelial cell;Knowledge;Lead;Link;Macrophage;MAP Kinase Gene;Mediating;Morbidity - disease rate;mortality;Mus;Mutation;Natriuresis;Nephrons;new therapeutic target;Non-Steroidal Anti-Inflammatory Agents;novel strategies;patch clamp;Pathogenesis;Pathway interactions;Patients;Phenotype;Phosphorylation;PIK3CG gene;Play;preservation;Production;Prostaglandins;Protein Kinase C;protein kinase C kinase;Public Health;Quality of life;receptor expression;Receptor Inhibition;Regulation;renal epithelium;Renal tubule structure;Renin-Angiotensin System;Research;Resistance;response;Risk Factors;Role;Severities;Signal Pathway;Signal Transduction;single cell sequencing;single-cell RNA sequencing;Smooth Muscle Myocytes;Sodium;Specificity;Techniques;Testing;Tissues;Transgenes;Transgenic Mice;Transgenic Organisms;urinary;vacuolar H+-ATPase;Vascular Smooth Muscle;WFDC2 gene;Work

PROJECT_TITLE: The role of kidney epithelial cells specific EP4 receptors in blood pressure control


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

PI_NAMEs: WOOD-JOHNSON, LAKAIJA J (contact)

PROJECT_TITLE: BRIDGE Center Teaming Core

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IMST-K]


ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: PROJECT NARRATIVE Puberty is a unique developmental process in which the body develops secondary sexual characteristics and becomes capable of reproduction, yet the mechanisms leading to pubertal onset are not well understood and an important area of scientific exploration. This proposal aims to understand how an important gene, Makorin Ring Finger Protein 3 (MKRN3), which has been associated with early puberty in children, may also be involved in causing delayed puberty, as preliminary studies show that increased expression of Mkrn3 leads to delayed puberty in female mice. The goal of this career development award is to gain further expertise in understanding puberty regulation using both innovative mouse models and human studies, to ultimately improve child health through improving diagnosis and management of disorders of puberty.

PI_NAMEs: ROBERTS, STEPHANIE ANNE (contact)

PROGRAM_OFFICER_NAME: WINER, KAREN

PROJECT_TERMS: Accounting;Area;Bilateral;Bone Density;Brain;Caenorhabditis elegans;Characteristics;Child;Child Health;Chromosomes;Clinical;Code;cohort;Complex;Data;Delayed Puberty;Developmental Process;Diagnosis;Disease;Disease Management;DNA Sequence Alteration;Dynorphins;Estrus;Female;Future;Genes;Genetic;genetic variant;GNRH1 gene;Goals;Health;Human;hypothalamic pituitary gonadal axis;Hypothalamic structure;Impairment;improved;in vivo;inhibitor;Injections;innovation;Investigation;K-Series Research Career Programs;KISS1 gene;Klinefelter's Syndrome;Lead;Life;long-term sequelae;loss of function mutation;Mediator;Messenger RNA;Modeling;mouse model;mRNA Transcript Degradation;Mus;neonatal mice;Neurokinin B;Neurons;Neuropeptides;Neurosecretory Systems;novel;overexpression;Patients;peer;Periodicity;Phenotype;Physiological;Precocious Puberty;premature;Premature Menopause;prepuberty;protein degradation;protein structure;Proteins;psychosocial wellbeing;pubertal timing;Puberty;Recombinant adeno-associated virus (rAAV);recombinant virus;Regulation;Reporting;Reproduction;reproductive;Ring Finger Domain;Risk;RNA Binding;Role;sex;Sex Differentiation;Structure;Structure of nucleus infundibularis hypothalami;therapeutic target;Time;tool;Transgenes;Transgenic Mice;Transgenic Organisms;ubiquitin-protein ligase;Untranslated RNA;Variant

PROJECT_TITLE: The effects of Mkrn3 on delayed puberty

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Reproduction, Andrology, and Gynecology Study Section[CHHD-R]


NIH_SPENDING_CATS: Bioengineering;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

PROJECT_TERMS: Address;Adopted;Adoption;Anatomy;Artificial Intelligence;Awareness;Back;Behavioral;Benchmarking;Bridge to Artificial Intelligence;Businesses;Communities;Confusion;Consultations;Consumption;dashboard;Data;Data Collection;data dissemination;Data Engineering;data harmonization;data ingestion;data modeling;Data Provenance;data quality;data reuse;Data Scientist;Data Set;data sharing;data standards;Deposition;Development;Discipline;Disease;Disparate;Documentation;Ecosystem;Elements;empowerment;Ensure;Environment;Equipment and supply inventories;Evaluation;FAIR principles;Generations;Genes;Goals;Human;insight;interoperability;Investments;Knowledge;Language;large datasets;Licensing;Life Cycle Stages;Link;Machine Learning;machine learning model;Modality;Modeling;Modernization;Molecular;Morphologic artifacts;novel;Ontology;open source;Output;Phenotype;programs;Protocols documentation;Provider;quality assurance;Quality Control;Readiness;Registries;Reporting;Reproducibility;Research;Research Personnel;Resources;response;Sea;Semantics;Services;skills;Source;Specific qualifier value;Specificity;Standardization;System;Terminology;Time;tool;Training;Translational Research;United States National Institutes of Health;Update;Variant;Vocabulary;web portal;Work;working group

PROJECT_TITLE: BRIDGE Center Standards Core