ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Genetics;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Embryonic - Non-Human

ORG_CITY: PHILADELPHIA

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Nearly 50% of the human genome is made up of mobile elements and ancient retroviruses called RetroElements (REs) that are present in thousands of nearly identical copies. As REs are paradoxically expressed during preimplantation development and recent findings reveal that RE reactivation is precise and essential for mammalian development, this proposal seeks to establish the functional importance and mechanistic basis of RE reactivation through gene editing, comparative biology and novel CRISPR based screening. Notably, REs are unintentionally reactivated in aging, autoimmunity, neurodegeneration and cancer and we predict that by cataloging RE-based mechanisms in embryos and identifying RE-regulation, we can therapeutically manipulate REs in adult tissue to mitigate or potentially reverse disease states.

PI_NAMEs: MODZELEWSKI, ANDREW JOSEPH (contact)

PROGRAM_OFFICER_NAME: MACARTHUR, LINDA

PROJECT_TERMS: Adult;Aging;Atlases;Autoimmunity;blastocyst;Cataloging;catalyst;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Comparative Biology;CRISPR screen;CRISPR/Cas technology;Defect;Development;Disease;Elements;Embryo;Ensure;Epigenetic Process;epigenetic silencing;Event;Family;gene network;Genes;Genetic;Genome;genome editing;Goals;Health;Human;human embryonic development;Human Genome;humanized mouse;Immobilization;improved;In Vitro;in vivo;innovation;Junk DNA;Malignant Neoplasms;mammalian genome;Modeling;Molecular;mouse model;Mus;Mutation;Nerve Degeneration;novel;Parasites;Pathology;Pattern;pluripotency;Pre-implantation Embryo Development;preimplantation;programs;Property;Regulation;Retroelements;Retrotransposon;Retroviridae;single cell technology;Structure;Technology;Therapeutic;Tissues;tool;Totipotency;transcriptome sequencing;Variant;Viral Physiology

PROJECT_TITLE: Defining developmentally regulated retroelement-based mechanisms to better understand and treat their dysregulation in disease.


ADMINISTERING_IC: HL

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Bioengineering;Eye Disease and Disorders of Vision;Lung;Orphan Drug;Pulmonary Fibrosis;Rare Diseases;Regenerative Medicine

ORG_CITY: HOUSTON

ORG_COUNTRY: UNITED STATES

ORG_DEPT: SURGERY

ORG_FIPS: US

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: PROJECT NARATIVE Although inflammation is a major driver of mortality in patients with acute respiratory distress syndrome (ARDS), systemic immunomodulation remains plagued by poor biodistribution to the lung, toxicity, infections due to deleterious systemic immunosuppression, and paradoxical pro-inflammatory responses, all of which limit clinical translation. This project will address these shortcomings by utilizing a novel cell therapy platform to: (i) enable sustained cell survival and delivery of secretory proteins locally to the lung via the airway or pleural cavity; (ii) understand local cytokine delivery modulates lung immune populations to promote lung tissue repair; and (iii) translate therapy in a clinically relevant fashion to a large animal model of ARDS. Overall, these studies will develop therapeutic “off-the-shelf” cell therapy system with sustained survival and functionality for application for ARDS.

PI_NAMEs: GHANTA, RAVI K (contact);VEISEH, OMID

PROGRAM_OFFICER_NAME: ESPINOZA GRANDON, INGRID CECILIA

PROJECT_TERMS: absorption;Acute;Acute Respiratory Distress Syndrome;Affect;Alginates;alveolar epithelium;American;anakinra;angiogenesis;Animal Model;AP 1903 reagent;Apoptotic;Biodegradation;Biodistribution;Bleomycin;Bronchoscopes;capsule;Catheters;Cell Physiology;Cell Survival;Cell Therapy;Cell Transplantation;Cells;Chronic;clinical translation;clinically relevant;Combined Modality Therapy;Contact Inhibition;cytokine;Cytometry;Death Rate;design;Development;Dose;Drug Kinetics;Encapsulated;Endothelial Cells;Endothelium;Endotoxins;Engineering;Family suidae;Fibroblasts;Fibrosis;fibrotic interstitial lung disease;fibrotic lung;Formulation;Gases;Growth;Histology;Human;Immune;Immune Evasion;Immune response;Immune system;immunoregulation;Immunosuppression;Implant;implantation;improved;improved outcome;In Situ;in vivo;Infection;Inflammation;Inflammatory;Inflammatory Response;Influenza;Injury;innovation;insight;Interleukin-10;Interstitial Lung Diseases;Leukocytes;Link;Lipopolysaccharides;Lung;lung repair;Lung Transplantation;Mechanics;Microcapsules drug delivery system;Modeling;mortality;nonhuman primate;novel;novel strategies;paracrine;Pathogenicity;Patients;Physiological;Play;Pleural;Pleural cavity;Population;porcine model;Pre-Clinical Model;prevent;Pulmonary alveolar structure;Pulmonary Fibrosis;pulmonary function;Pulmonary Inflammation;Rattus;Recovery of Function;repaired;Respiratory Failure;retina implantation;Role;Safety;secretory protein;single-cell RNA sequencing;small molecule;Structure of retinal pigment epithelium;success;Surface;Survivors;System;Testing;Therapeutic;Time;tissue repair;Tissues;Titrations;Toxic effect;Translating;Viral

PROJECT_TITLE: Cell Based Immunomodulation to Suppress Lung Inflammation and Promote Repair

STUDY_SECTION: DBTD

STUDY_SECTION_NAME: Drug and Biologic Therapeutic Delivery Study Section[DBTD]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Machine Learning and Artificial Intelligence;Microbiome

ORG_CITY: SEATTLE

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project narrative Advances in omics technologies – such as genomics, transcriptomics, proteomics, and metabolomics, and microbiomes – have introduced an unprecedented level of granularity into both clinical and bio- logical measurements. However, using these data to discern causal factors and mechanisms under- lying diseases is challenging due to their high dimensionality, correlation, and complexity. The current proposal aims to address this gap by developing rigorous causal inference methods and software for integrative analysis of omics data, providing new insights on disease etiology and ultimately transform the potential of massive biomedical data into trustworthy, actionable, and generalizable knowledge to solve public health challenges.

PI_NAMEs: YE, TING  (contact)

PROGRAM_OFFICER_NAME: WANG, PEGGY

PROJECT_TITLE: Advancing Causal Inference in Integrative Omics Analysis

STUDY_SECTION: MRAF

STUDY_SECTION_NAME: Maximizing Investigators' Research Award - F Study Section[MRAF]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

ORG_CITY: BRONX

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

ORG_STATE: NY

PHR: Program Narrative While Hispanics are the fastest growing segment of the U.S. population, they are significantly underrepresented at all levels in the scientific community. This proposal is designed to increase the numbers of underrepresented minorities into academic science by promoting the career development of postdoctoral scholars as science researchers and educators through a partnership between Einstein as a research-intensive institution and Hostos Community College and Lehman College, both Hispanic-serving teaching institutions. The activities of this program and of postdoctoral scholar scientist/educators supported by the program will increase the pool of capable undergraduates interested in research at the partner institutions. Ultimately, it is expected that this program will enhance the numbers of underrepresented minorities in academic science, who will, in turn, contribute research findings of benefit to the health and welfare of diverse US citizenry.

PI_NAMEs: COX, DIANNE  (contact)

PROGRAM_OFFICER_NAME: BLATCH, SYDELLA ANNE

PROJECT_TERMS: Academia;Applications Grants;career;career development;Collaborations;Communities;County;Couples;Educational Curriculum;Educational process of instructing;Educational workshop;expectation;experience;Faculty;Funding;Future Generations;Goals;Grant;Hispanic;Hispanic Populations;Individual;innovation;Institution;Joints;Laboratories;Learning;Mentors;Minority;Minority Groups;minority undergraduate;Minority-Serving Institution;Mission;New England;Outcome;pedagogy;Population;Positioning Attribute;Postdoctoral Fellow;programs;Qualifying;Research;Research Project Grants;Science;Scientist;skill acquisition;skills;Students;success;symposium;Techniques;Training;Training Support;undergraduate student;Underrepresented Minority;Underrepresented Populations;urban setting;Work;Writing

PROJECT_TITLE: Bronx-Einstein Training in Teaching and Research (BETTR), an IRACDA program

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - C[TWD-C]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Physical Activity;Prevention;Rehabilitation

ORG_CITY: COLUMBIA

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

ORG_STATE: SC

PHR: Scalable approaches for increasing physical activity are needed for the growing population of adults with knee replacement. This project aims to identify which supplemental non-automated intervention components added to a fully-automated online physical activity program contribute to the greatest increases in physical activity at 6 and 12 months. Based on these results, an optimized remotely delivered physical activity program will be developed for adults with knee replacement.

PI_NAMEs: PELLEGRINI, CHRISTINE ANN (contact);UNICK, JESSICA L

PROGRAM_OFFICER_NAME: NELLISSERY, MAGGIE JACOB

PROJECT_TERMS: Accelerometer;Accountability;Address;Adherence;Adult;Alzheimer's Disease;automated intervention;Behavioral;Cardiovascular Diseases;Cessation of life;Chronic Disease;clinical practice;Competence;cost;Dementia;design;Development;Disease;effectiveness testing;Electronic Mail;Exercise;exercise intervention;exercise program;experience;Feedback;Fostering;Future;Goals;Guidelines;Healthcare Systems;High Prevalence;high risk;Human;improved;Individual;Internet;Intervention;intervention cost;intervention effect;knee replacement arthroplasty;Literature;Measures;Mediating;meetings;Modeling;mortality;mortality risk;multiphase optimization strategy;Nature;Operative Surgical Procedures;Outcome;Pain;Pain intensity;Participant;Persons;Physical activity;Physical Function;physical impairment;Physicians;Population;Population Replacements;prevent;Problem Solving;programs;Progress Reports;Randomized;Recommendation;recruit;remote delivery;remote intervention;Reporting;Research;Risk;Risk Reduction;Self Determination;social engagement;success;Surgeon;telephone coaching;Testing;theories;Time;translational potential;Travel;vigorous intensity

PROJECT_TITLE: Optimizing a Remote-based Physical Activity Intervention for Adults with Total Knee Replacement

STUDY_SECTION: LCBH

STUDY_SECTION_NAME: Lifestyle Change and Behavioral Health Study Section[LCBH]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Aging;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Nutrition;Obesity;Physical Injury - Accidents and Adverse Effects;Prevention;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_CITY: SAN ANTONIO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

PHR: Narrative Persons with spinal cord injury (SCI) develop diabetes more than able-bodied persons at an earlier age. Yet, the effectiveness and tolerability of recently developed anti-diabetic drugs, such as glucagon-like peptide 1 receptor agonists (GLP-1RAs), after SCI remains unknown, contributing to health inequity in diabetes management in this high-risk population. This project will examine the effectiveness of GLP-1R activation by 24-week administration of semaglutide on glucose tolerance, insulin action, and body lean/ fat mass in patients with SCI and diabetes subtype that manifests by severe sarcopenia and beta-cell and autonomic dysfunction in addition to exaggerated insulin resistance.

PI_NAMEs: SALEHI, MARZIEH  (contact)

PROGRAM_OFFICER_NAME: GOROSPE, RAFAEL

PROJECT_TERMS: Acute;Adipose tissue;Affect;Age;Agonist;Anti-diabetic Drugs;Autonomic Dysfunction;Autonomic nervous system;Beta Cell;Body fat;Body mass index;Body Weight;Body Weight decreased;Cardiovascular Diseases;cardiovascular risk factor;Cardiovascular system;Cell Physiology;Cessation of life;Chronic;Clinical Research;Closure by clamp;cohort;Complex;Data;Deterioration;Development;diabetes management;Diabetes Mellitus;diabetic;diabetic patient;diabetogenic;Disease;Double-Blind Method;Dual-Energy X-Ray Absorptiometry;Effectiveness;effectiveness evaluation;Endocrine;Enrollment;Equilibrium;euglycemia;experimental study;Fatty acid glycerol esters;Fibrosis;Formularies;Functional disorder;GLP-I receptor;Glucose;Glucose Plasma Concentration;glucose tolerance;glycemic control;Guidelines;health disparity;health equity;Health Hazards;health inequalities;Hepatic Tissue;high risk;high risk population;Human;Impairment;improved;Individual;individual patient;Infusion procedures;Ingestion;Injury;insight;Insulin;Insulin Resistance;insulin secretion;insulin sensitivity;Intervention;Knowledge;Liver;Measures;metabolic abnormality assessment;Metformin;Modeling;Muscle;Muscular Atrophy;Myocardial Infarction;Neurologic;neuroprotection;Non-Insulin-Dependent Diabetes Mellitus;Obesity;Oral;Package Insert;Patients;Persons;Pharmaceutical Preparations;Phase;Placebos;Population;pre-clinical;preservation;prevent;Prevention strategy;Randomized;randomized placebo controlled study;randomized, clinical trials;Rattus;Receptor Activation;Recommendation;Reporting;Research Design;response;Risk;Role;Safety;sarcopenia;Spinal cord injury;Spinal cord injury patients;Stroke;Technology;Testing;Texas;Therapeutic;Thinness;Time;Tracer;treatment strategy;Virulence Factors

PROJECT_TITLE: Glycemic and Weight Loss Effects of Semaglutide in Subjects After Spinal Cord Injury and Type 2 Diabetes

STUDY_SECTION: HSDO

STUDY_SECTION_NAME: Human Studies of Diabetes and Obesity Study Section[HSDO]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

ORG_CITY: CORAL GABLES

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF MIAMI CORAL GABLES

ORG_STATE: FL

PHR: Project Narrative Small molecular drugs play a pivotal role in treating a wide range of diseases including cancer and infection, yet many of them suffer from unsatisfactory efficacy and severe side effects with current drug delivery systems. This proposal aims to develop innovative strategies to improve the biodistribution and pharmacokinetics of small molecular drugs, especially those with unfavorable physiochemical properties, ultimately offering novel tools to improve disease treatment.

PI_NAMEs: ZHANG, FUWU  (contact)

PROGRAM_OFFICER_NAME: KODURI, SAILAJA

PROJECT_TERMS: Adverse effects;Albumins;Antibody-drug conjugates;Binding;Biodistribution;Cardiovascular Diseases;Chemistry;cytotoxicity;design;Development;Disease;Drug Delivery Systems;Drug Kinetics;Engineering;Hydrophobicity;improved;In Vitro;in vivo;Infection;innovation;Kinetics;Length;Ligands;Link;Liposomes;Malignant Neoplasms;materials science;Micelles;Molecular;nanocarrier;nanomedicine;nanoparticle;novel;novel strategies;Organic Chemistry;Outcomes Research;Pharmaceutical Preparations;Play;Polymer Chemistry;polymerization;Polymers;Prodrugs;Property;Research;Role;self assembly;side effect;Site;small molecule;Solubility;systemic toxicity;Therapeutic Agents;tool;Treatment Efficacy;uptake

PROJECT_TITLE: Prodrug engineering for enhanced biodistribution and pharmacokinetics

STUDY_SECTION: MRAE

STUDY_SECTION_NAME: Maximizing Investigators' Research Award - E Study Section[MRAE]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: DALLAS

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: PROJECT NARRATIVE Resistance to current AR-targeted therapies poses a significant hurdle in treating advanced prostate cancer (PCa), severely affecting clinical outcomes for patients battling this lethal disease. Our research has identified UBE2J1 as the bona fide E2 ubiquitin-conjugating enzyme regulating AR ubiquitination and revealed its frequent loss in 10-15% patients leads to dysregulated AR degradation and therapy resistance. This study seeks to elucidate the previously uncharted molecular mechanisms behind AR degradation and resistance to therapy in the context of UBE2J1-loss, with the ultimate goal of devising novel therapeutic strategies to counteract resistance and enhance patient outcomes.

PI_NAMEs: MU, PING  (contact)

PROGRAM_OFFICER_NAME: KOHAAR, INDU

PROJECT_TERMS: Accountability;advanced prostate cancer;Affect;Androgen Receptor;antagonist;Automobile Driving;Cancer Patient;Cells;Clinical;clinically relevant;combat;Complication;Comprehension;Development;Disease;Drug resistance;Effectiveness;Employment;Enzymes;Generations;Goals;Growth;Human;improved;In Vitro;in vivo;in vivo Model;innovation;insight;Light;Malignant neoplasm of prostate;Mediating;Modeling;Modernization;Molecular;Neoplasm Metastasis;novel therapeutic intervention;novel therapeutics;Oncogenic;Outcome;Patient-Focused Outcomes;Patients;Physiological Processes;Physiology;Play;predictive marker;Predictive Value;Process;Proliferating;prostate cancer model;prostate carcinogenesis;protein degradation;Proteins;receptor;receptor function;Receptor Signaling;Research;Resistance;Resolution;response biomarker;Role;single-cell RNA sequencing;Site;success;targeted treatment;Therapeutic;therapy resistant;transcriptome;transcriptomics;tumor;tumor heterogeneity;tumor initiation;tumorigenesis;Ubiquitin-Conjugating Enzymes;ubiquitin-protein ligase;Ubiquitination

PROJECT_TITLE: Unveiling the Role of UBE2J1 as the E2 Ubiquitin Conjugating Enzyme in Androgen Receptor Degradation

STUDY_SECTION: MCTB

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics B Study Section[MCTB]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Maternal Health;Mental Health;Neurosciences;Pediatric;Pregnancy;Prevention;Sleep Research;Women's Health Research

ORG_DEPT: PHARMACOLOGY

PHR: Prenatal insults elevate risks to both maternal and offspring health. We will investigate enhanced tryptophan to kynurenine metabolism as a shared mechanism of prenatal insults in an effort to define, treat, and prevent adverse sleep and metabolism dynamics that disrupt a healthy pregnancy. The following proposal is designed to test the novel hypothesis that elevated kynurenic acid during the prenatal developmental period is causally linked to poor quality sleep and cognitive dysfunction.

PI_NAMEs: POCIVAVSEK, ANA  (contact)

PROGRAM_OFFICER_NAME: LAPOSKY, AARON D

PROJECT_TERMS: Adult;Adult Children;adverse outcome;antagonist;Astrocytes;Attenuated;Automobile Driving;Autopsy;Behavior;Behavioral;behavioral impairment;behavioral outcome;Bipolar Disorder;Brain;Brain region;Cerebrospinal Fluid;Chemosensitization;Child;Choline;choline supplementation;cholinergic;circadian;Cognition;cognitive function;comparison intervention;Data;design;Deterioration;Development;Diet;Down-Regulation;Electrophysiology (science);endophenotype;Environment;Enzymes;extracellular;Eye;FDA approved;feeding;fetal;Functional disorder;Gene Transfer;Goals;Health;Health Promotion;healthy pregnancy;hypocretin;Hypothalamic structure;immune activation;Impaired cognition;improved;improvement on sleep;Individual;inhibitor;innovation;interest;Kynurenic Acid;Kynurenine;kynurenine aminotransferase II;Lateral;learned behavior;Link;maternal morbidity;Maternal Mortality;maternal outcome;Mediating;Metabolism;Molecular;Monitor;Movement;N-Methyl-D-Aspartate Receptors;N-Methylaspartate;neurochemistry;Neurocognitive Deficit;neurodevelopment;Neurodevelopmental Disorder;neurotransmission;Neurotransmitters;novel;novel therapeutic intervention;novel therapeutics;offspring;Outcome;Pathologic;Pathway interactions;Periodicity;pharmacologic;Play;poor health outcome;poor sleep;Pregnancy;pregnant;Pregnant Women;prenatal;prevent;Rattus;receptor;Reducing diet;Research;Risk;Role;Safety;saliva sample;Schizophrenia;septohippocampal;Site;Sleep;Sleep Architecture;sleep behavior;Sleep Deprivation;Sleep Disorders;Sleep disturbances;sleep quality;Stress;Testing;Tryptophan;Tryptophan Metabolism Pathway;Up-Regulation;Virus;young adult

PROJECT_TITLE: Kynurenic Acid and Sleep: Focus on Maternal and Offspring Health

STUDY_SECTION: BNRS

STUDY_SECTION_NAME: Behavioral Neuroendocrinology, Neuroimmunology, Rhythms, and Sleep Study Section [BNRS]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences;Nutrition

ORG_CITY: SYRACUSE

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UPSTATE MEDICAL UNIVERSITY

PHR: PROJECT NARRATIVE Feeding is crucial for survival, but dysregulation can cause disorders like obesity and anorexia; many animals, including humans, have distinct meal patterns that are tightly regulated by satiety signals; however, the specific roles of macronutrients in regulating feeding remain unclear. By using Drosophila as a model organism, this project aims to uncover the intricate molecular and neural mechanisms that underlie nutrient- specific feeding behavior. The expected mechanistic insights from this investigation will provide a valuable understanding of how the brain integrates information about specific macronutrients to regulate feeding behavior.

PI_NAMEs: LIN, HUI-HAO  (contact)

PROGRAM_OFFICER_NAME: CUMMINGS, DIANA M

PROJECT_TITLE: The integration of nutrient-specific satiety signals in the brain to control food intake.

STUDY_SECTION: NIC

STUDY_SECTION_NAME: Neuroscience of Interoception and Chemosensation Study Section[NIC]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Nutrition;Pediatric;Prevention;Social Determinants of Health

PHR: The Supplemental Nutrition Assistance Program (SNAP) has financial incentive programs, where families enrolled in SNAP can purchase fruits and vegetables (F&V), at select sites, for half the price or less, leading to increased F&V consumption and projected savings in healthcare costs. Yet, limited awareness and uptake of SNAP F&V incentive programs presents a major barrier to widespread utilization and limits the potential impact of these existing programs. This study aims to leverage pediatric clinic settings to identify eligible families and increase awareness and utilization of SNAP F&V incentive programs by offering vouchers for an initial “free trial” and home delivery services of F&V purchased as part of this program to improve diet quality and lower long-term disease risk.

PI_NAMEs: ADAMS, ELIZABETH  (contact)

PROGRAM_OFFICER_NAME: EVANS, MARY

PROJECT_TERMS: 10 year old;2 arm randomized control trial;acceptability and feasibility;Adoption;Age;Awareness;Black race;cardiovascular disorder risk;Caregivers;Child;Childhood;Chronic Disease;Clinic;Clinic Visits;Communities;community advisory board;community organizations;community partners;comparison control;Consolidated Framework for Implementation Research;Consumption;Control Groups;cost;Data;Diet;dietary;Dietary Assessment;disorder risk;Disparity;Education;effectiveness outcome;effectiveness testing;Electronics;Eligibility Determination;Enrollment;experience;Family;Feedback;Female;financial incentive;follow-up;Food;food insecurity;food security;fruits and vegetables;Funding;Future;group intervention;Health;Health Care Costs;Healthy Eating;Home;Hour;Household;Hunger;implementation intervention;improved;incentive program;indexing;Individual;informant;innovation;Intervention;Interview;Knowledge;Methods;Non-Insulin-Dependent Diabetes Mellitus;novel;nutrition;operation;Outcome;Parents;pediatrician;Physicians;Pilot Projects;Policies;Price;primary outcome;process evaluation;programs;Public Health;Randomized;Recipe;recruit;Reporting;response;Savings;screening;secondary outcome;Security;service delivery;Services;Signal Transduction;Site;social;South Carolina;symposium;Testing;Time;Transportation;United States Department of Agriculture;United States National Institutes of Health;uptake;Visit;voucher;Waiting Lists;web portal;Well Child Visits;Work

PROJECT_TITLE: Increasing Use of SNAP Fruit and Vegetable Incentive Programs for Families with Food Insecurity

STUDY_SECTION: HPC

STUDY_SECTION_NAME: Health Promotion in Communities Study Section[HPC]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Brain Disorders;Dementia;Nanotechnology;Neurodegenerative;Neurosciences

ORG_CITY: Nashville

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: PROJECT NARRATIVE The goal of our research program is to advance spectroscopic methods capable of providing new insight into structural changes induced by protein-protein and protein-surface interactions in complex environments that impact human health. Our first research direction aims to develop methods that can be applied broadly to extract the detailed structural dynamics of protein complexes within biological media, which will be demonstrated by studying the aggregation of β-amyloid in cerebrospinal fluid to gain unprecedented insight into physiologically relevant prefibrillar structures and self-assembly pathways that may drive the pathology of Alzheimer’s Disease. Our second research direction aims to resolve the residue-level structural changes that occur when proteins interact with nanoparticle surfaces in order to understand the underlying cause of adverse responses to nanoparticle exposure, as well as design bio-nano conjugated materials with specific functionalities.

PI_NAMEs: BUCHANAN, LAUREN E (contact)

PROGRAM_OFFICER_NAME: CHO, THOMAS Y

PROJECT_TERMS: abeta accumulation;Adsorption;Affect;Alzheimer's Disease;Alzheimer's disease pathology;Amyloid beta-Protein;Biological;Biological Models;Cerebrospinal Fluid;Chemistry;Complex;design;Disease;Environment;functional group;Goals;Health;Human;improved;In Vitro;insight;Label;Machine Learning;Maps;Measures;Membrane Proteins;metallicity;Methods;Modeling;Muramidase;nanomaterials;nanoparticle;nanoparticle exposure;Organism;Pathway interactions;Peptides;Physiological;programs;protein aggregation;protein complex;Protein Dynamics;protein structure;Proteins;Research;Resolution;response;Role;self assembly;Silicon Dioxide;Site;Spectrum Analysis;Structure;Surface;System;Time;two-dimensional;unnatural amino acids

PROJECT_TITLE: Probing protein structure and aggregation in complex environments with 2D IR spectroscopy

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


NIH_SPENDING_CATS: Genetics

ORG_CITY: STORRS-MANSFIELD

ORG_NAME: UNIVERSITY OF CONNECTICUT STORRS

ORG_STATE: CT

PHR: Supernumerary chromosomes are extra, nonessential chromosomes that are derived from the essential chromosomes. Despite their ability to negatively impact human health, many fundamental aspects regarding their formation and dynamics are understudied. The proposed research aims to use the newly established B chromosome model system in D. melanogaster to answer outstanding scientific questions about supernumerary chromosome biology, which will reveal the genetic conditions that permit them to form, how they disrupt the stability of the essential chromosomes, and what defenses the cell uses to protect against their passage to the next generation.

PI_NAMEs: HANLON, STACEY L (contact)

PROGRAM_OFFICER_NAME: MILLER, RITA K

PROJECT_TERMS: Affect;Aneuploidy;Bioinformatics;Biological Assay;Biological Models;Biology;Cells;Chromosomes;Chromosomes, Human, 4-5;Cytology;Development;developmental disease;DNA sequencing;Environment;Etiology;Female;Genetic;genetic analysis;genetic approach;Genetic Diseases;Growth;Health;Human;Image;Infertility;Investigation;Knowledge;Malignant Neoplasms;Maps;Meiosis;Methods;Modeling;Molecular;next generation;Positioning Attribute;prevent;Prevention;Reproduction;Research;System;Technology;tool;transmission process;Work

PROJECT_TITLE: Investigating supernumerary chromosome biology using the B chromosome model system

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Genetics;Human Genome;Immunization;Immunotherapy;Pancreatic Cancer;Prevention;Rare Diseases;Vaccine Related

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: NARRATIVE Once the diagnosis of pancreatic cancer is made, the possibility of survival is dismal at only 12% over 5 years despite conventional therapy––making this cancer type amongst the most difficult to treat. However, it has been gleaned that early pre–cancer progresses to cancer over a decade and those at a high risk of progression can be identified by genetic testing and radiology. Here, we will test the ability of a new vaccine against a cancer driver molecule KRAS to halt cancer progression in high–risk patients by activating the immue system to detect and kill pre–malignant cells.

PI_NAMEs: ZAIDI, NEEHA  (contact)

PROGRAM_OFFICER_NAME: HENDERSON, LORI A

PROJECT_TERMS: Architecture;Back;cancer invasiveness;cancer type;Cancer-Predisposing Gene;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;Cells;Clinical;Clinical Trials;Clonality;cohort;combinatorial;Complement;conventional therapy;Cytometry;cytotoxic;Data;Data Set;Detection;Development;Diagnosis;Disease-Free Survival;Distant;Early Diagnosis;Ensure;Epitopes;Evaluation;Evolution;Excision;exhaustion;Family;Genetic Predisposition to Disease;genetic signature;genetic testing;Germ Lines;Germ-Line Mutation;Glean;Goals;Heterozygote;high risk;high risk population;Histology;Human;Image;Immune;Immune checkpoint inhibitor;immunogenicity;Immunomodulators;improved;In Vitro;Incidence;Individual;Intercept;Interferon Type II;Knock-in;KPC model;KRAS2 gene;KRASG12D;Lasers;Length;Lesion;Listeria;Malignant neoplasm of pancreas;Malignant Neoplasms;Maps;Memory;Modality;Morbidity - disease rate;mouse model;Mucinous;Mucinous Neoplasm;Mus;mutant;Mutate;Mutation;Neoplasm Metastasis;Neoplasms;novel;novel vaccines;Oncogenic;Operative Surgical Procedures;Pancreatic Ductal Adenocarcinoma;Pancreatic Intraepithelial Neoplasia;Papillary;participant enrollment;Pathogenicity;Pathology;Patients;Peptide Vaccines;Peptides;Peripheral;peripheral blood;Phenotype;premalignant;Premalignant Cell;prevent;progression risk;Proteins;Radiology Specialty;Recording of previous events;recruit;Regulatory T-Lymphocyte;Resected;Resistance;Role;Safety;safety study;Signal Transduction;single-cell RNA sequencing;Survival Analysis;System;T cell receptor repertoire sequencing;T cell response;T-Lymphocyte;Tamoxifen;Technology;Testing;therapy resistant;Time;Tissues;trafficking;transcriptome sequencing;transcriptomics;Translations;Tumor Immunity;tumor initiation;tumor progression;vaccine evaluation;vaccine immunogenicity;Vaccines;Validation;Variant

PROJECT_TITLE: Mutant KRAS targeted vaccines for the interception of pancreatic cancer development

STUDY_SECTION: CONC

STUDY_SECTION_NAME: Clinical Oncology Study Section[CONC]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Infectious Diseases;Malaria;Orphan Drug;Rare Diseases;Vector-Borne Diseases

ORG_CITY: LEXINGTON

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: Project Narrative Malaria, a disease caused by Plasmodia parasites, afflicts approximately 240 million individuals and kills up to 630,000 each year. A significant problem with fielding effective antimalarial medicines is that the malaria parasites become resistant to treatment over time, causing drugs to stop working. We are using our understanding of the mechanism of action of a new class of antimalarial drugs, the ATP4 inhibitors, to direct selection of the best medicines from other classes to combine with ATP4 inhibitors to minimize drug resistance arising and lengthen the time they can be effectively used to treat malaria.

PI_NAMEs: DERISI, JOSEPH L.;GUY, RODNEY KIPLIN (contact)

PROGRAM_OFFICER_NAME: MO, ANNIE X  Y

PROJECT_TERMS: acquired drug resistance;Address;Affect;Africa;Anti-malarial drug resistance;Anti-malarials;artemether;Artemisinins;artesunate;atovaquone;Automobile Driving;benflumetol;Blood;candidate identification;Cessation of life;Clinic;Clinical;clinical development;clinical risk;Clinical Trials;clinically relevant;clinically significant;Collaborations;combat;Combined Modality Therapy;cost;design;Development;Disease;Disparity;Dose;drug action;Drug Combinations;Drug Exposure;Drug resistance;Educational process of instructing;Erythrocytes;Excision;experimental study;fitness;Frequencies;Future;Genetic;Genomics;Goals;Growth;Health;Human;humanized mouse;improved;In Vitro;in vivo;in vivo Model;Individual;Infection;inhibitor;inhibitor therapy;innovation;Knock-in;Laboratories;Macrophage;Malaria;Mediating;Medicine;Methods;Modeling;Mus;mutant;Mutation;Nature;novel;novel therapeutics;Parasite resistance;Parasites;Patients;Pattern;Pharmaceutical Preparations;Pharmacodynamics;pharmacologic;Pharmacology;Phase;Plasma;Plasmodium;Plasmodium falciparum;Plasmodium vivax;pressure;prevent;Probability;pyronaridine;Regimen;Research;Resistance;Resistance development;resistance mechanism;resistance mutation;resistant strain;Risk;risk minimization;risk mitigation;Role;Schedule;Signal Transduction;Southeastern Asia;Speed;Spleen;targeted treatment;Testing;Time;treatment duration;Variant;Vivax Malaria

PROJECT_TITLE: Interactions between drug combinations and resistance acquisition risk for antimalarial ATP4 inhibitors

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-M (81)]


ORG_CITY: RALEIGH

ORG_NAME: NORTH CAROLINA STATE UNIVERSITY RALEIGH

ORG_STATE: NC

PHR: 2023. NIH MIRA project narrative Title: Chemical labeling strategies using biomolecule-compatible, nonaqueous media The proposed research is relevant to public health because chemical labeling of proteins allows for the deeper understanding of their roles in living systems including disease states as well as the application of such labeled biomolecules for therapeutic and diagnostic applications. The proposed research program will tackle the long-standing issues of realization of efficient, selective chemical labeling of proteins using biomolecule-compatible nonaqueous media, and the proposed research is relevant to the part of the NIH’s mission that pertains to creation/improvement of therapeutic agents.

PI_NAMEs: OHATA, JUN  (contact)

PROGRAM_OFFICER_NAME: ASLAN, KADIR

PROJECT_TERMS: Address;Amino Acids;aqueous;chemical reaction;Chemicals;Development;Diagnostic;Disease;disease mechanisms study;Goals;Hydrophobicity;improved;innovation;Label;Literature;Methodology;Methods;Mission;Modification;novel;Organic Chemistry;Organism;Preparation;programs;Proteins;Public Health;Reaction;Research;Role;Site;Surface;Technology;Therapeutic;Therapeutic Agents;Therapeutic Studies;tool;United States National Institutes of Health


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Genetics;Human Genome;Mental Health;Neurosciences;Social Determinants of Health

ORG_CITY: ATLANTA

ORG_DEPT: PSYCHIATRY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative The social environment has profound effects on human biology and health, but we understand little about how and why these effects vary across individuals. We will address this knowledge gap by studying variability in responses to social stimuli in prairie voles, a uniquely social animal model in which individuals differ in their genetics, neurobiology, and behavior. Because many biological features are conserved between humans and other animals, this research is likely to identify candidate genetic, molecular, cellular, and neural circuit mechanisms underlying individual differences in human health and disease risk.

PI_NAMEs: JOHNSON, ZACHARY V (contact)

PROGRAM_OFFICER_NAME: STEPANEK, LAURIE ELIZABETH

PROJECT_TITLE: Cellular, neurogenomic and neuroendocrine mechanisms underlying variation in social behavior

STUDY_SECTION: MRAD

STUDY_SECTION_NAME: Maximizing Investigators' Research Award - D Study Section[MRAD]


NIH_SPENDING_CATS: Biotechnology

ORG_CITY: AMHERST

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

PHR: Narrative New drugs are needed to treat diseases, however the process by which they are produced is inefficient resulting in additional cost and time. We are working to gain knowledge through novel methods that will reduce the guesswork and streamline various aspects of drug development. In the long term, our work should lead to accelerated development of urgently needed medicines.

PI_NAMEs: HEPPNER, DAVID E. (contact)

PROGRAM_OFFICER_NAME: HARTON, MARIE DEBORAHGAYNELLE

PROJECT_TERMS: Acceleration;Area;Binding;Biological Assay;Biological Models;Breathing;chemical property;Chemical Structure;Confusion;Consumption;cost;Decision Making;design;Development;Disease;Drug Design;drug development;drug discovery;Epidermal Growth Factor Receptor;Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor;Exhibits;Future;Goals;Human;improved;inhibitor;innovation;insight;kinase inhibitor;Knowledge;Link;Medicine;Methods;Minor;Molecular;multidisciplinary;novel;novel therapeutics;Pharmaceutical Preparations;pharmacologic;Phosphotransferases;Process;Production;programs;Property;Protac;Protein Kinase;protein kinase inhibitor;Research;Shapes;structural determinants;Time;virtual;Work

PROJECT_TITLE: Improving Drug Development Through Studies of Protein Kinase Inhibitors


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research

ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: PROJECT NARRATIVE The ACCELERATE-BASSO Dissemination and Coordination Center (DCC) will serve as a backbone for the U01 Network on Accelerating Behavioral and Social Science through Ontology Development and Use to (1) facilitate collaboration and cross-project learning; (2) provide ontology-related technical, computational, and informatics expertise and support; (3) facilitate dissemination of resources and training to support ontology expansion, development, and use; and (4) provide active outreach and coordination with relevant stakeholders to increase understanding of and demand for BSSR ontology-related tools and resources.

PI_NAMEs: BIAN, JIANG  (contact);MUSEN, MARK A;TAO, CUI

PROGRAM_OFFICER_NAME: JAIN, KRITI MUNJAL

PROJECT_TERMS: Acceleration;Address;Adopted;Attention;Behavioral;behavioral and social science;behavioral study;Biological;biomedical ontology;Classification;Cognition;Collaborations;Communities;Complex;Consensus;data sharing networks;design;Development;Discipline;efficacious intervention;Emotions;Engineering;Environment;Evaluation;Face;FAIR principles;Genetic;Health;health science research;improved;Individual;Informatics;informatics tool;Information Resources;Infrastructure;Knowledge;Learning;Legal;Licensing;Life Cycle Stages;Maintenance;Manuals;Medicine;member;Minority-Serving Institution;Modeling;multidisciplinary;Ontology;ontology development;operation;Organism;outreach;Phenotype;Plug-in;Policies;Procedures;Process;Professional Organizations;programs;Recommendation;Records;Reporting;repository;Research;Research Project Grants;Resource Sharing;Resources;response;Science;social;social science research;Somatotype;Standardization;success;System;Technology;tool;tool development;Training;United States National Academy of Sciences;United States National Institutes of Health;user-friendly;Vertebral column;Visualization;working group

PROJECT_TITLE: ACCELERATE-BASSO: Coordinating Center for Accelerating Behavioral and Social Science through Ontology

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 SCIL-D (50)]


NIH_SPENDING_CATS: Biotechnology;Cancer

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: PROJECT NARRATIVE The human interactome, comprising over 650,000 interactions between various proteins, remains an underexplored frontier in therapeutic discovery. The significance of these interactions is highlighted by an exemplary interaction between MAGE-A4 (a melanoma protein) and RAD18 (a protein involved in DNA replication and repair), which is believed to enhance DNA damage tolerance and contribute to the resistance of cancer cells to chemotherapies. The work proposed herein aims to address fundamental questions about the design of potent macromolecule therapeutics targeting these protein-protein interactions, with anticipated outcomes including increased efficacy of chemotherapies.

PI_NAMEs: KNIGHT, ABIGAIL  (contact)

PROJECT_TERMS: Acceleration;Address;algorithm development;Algorithms;Antigens;Binding;Binding Proteins;bioactive scaffold;Biological;Biological Assay;Biological Models;cancer cell;Cells;Characteristics;chemotherapy;cost;Cyclization;design;Development;Disease;DNA biosynthesis;DNA Damage;DNA Repair;frontier;human interactome;innovation;macromolecule;Melanoma;Membrane Proteins;Methods;Molecular Conformation;Outcome;Peptides;peptidomimetics;Permeability;prediction algorithm;Property;protein protein interaction;Proteins;Resistance;Role;stapled peptide;Therapeutic;therapeutic target;ubiquitin-protein ligase;Vision;Work

PROJECT_TITLE: Identifying favorable regions of the conformational landscapes of peptides and peptidomimetics


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Data Science;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: HERSHEY

ORG_NAME: PENNSYLVANIA STATE UNIV HERSHEY MED CTR

ORG_STATE: PA

PHR: PROJECT NARRATIVE Kmers, which are short sequences of nucleic acids or peptides, are crucial for deciphering the immense amounts of genomic and proteomic information generated every day. Through the in-depth examination of kmers and artificial intelligence techniques, we aim to discern specific genomic patterns, gain insights in evolution, and develop advanced tools and resources for usage by the wider research community.

PI_NAMEs: GEORGAKOPOULOS-SOARES, ILIAS  (contact)

PROGRAM_OFFICER_NAME: YU, GUOQIN

PROJECT_TERMS: Algorithms;Area;Artificial Intelligence;artificial intelligence model;Base Sequence;Basic Science;Bioinformatics;Biological;Biological Process;Biomedical Research;Brain;Codon Nucleotides;Cognition;Collaborations;Communities;computing resources;Data;Data Analyses;data integration;Data Set;Databases;Development;Environment;Evolution;FAIR principles;Fostering;Frequencies;generative artificial intelligence;Genes;Genetic Transcription;genetic variant;Genome;Genomic Instability;Genomics;Goals;Human;improved;innovation;insight;Metagenomics;Methods;Modernization;open source;Organism;Pattern;Peptides;Play;Population Heterogeneity;Primates;Process;protein aminoacid sequence;Proteome;Proteomics;Quantitative Trait Loci;Research;Research Personnel;Resources;Role;Shapes;Software Tools;Taxonomy;Techniques;Technology;tool;trait;Translations;variant detection

PROJECT_TITLE: Harnessing the Power of Kmers: Concepts and Methods for Genomic and Proteomic Research


NIH_SPENDING_CATS: Congenital Structural Anomalies;Pediatric;Primary Immunodeficiencies;Rare Diseases

ORG_CITY: PITTSBURGH

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Barth syndrome (BTHS) is a mitochondrial X-linked genetic disease with severe cardio/skeletal myopathy which limits the quality of life or even causes premature death. Effective BTHS therapies are lacking due to incomplete understanding of the leading pathogenic mechanism. We propose expeditious pre-clinical testing of drugs targeting an entirely new pathogenic mechanism that have not been tested as BTHS mitigators. The mechanism is based on a newly discovered role of the major biochemical process of remodeling of essential and unique mitochondrial phospholipid, cardiolipin. We established that a remodeling intermediate, monolyso- cardiolipin, forms an aberrant complex with a Fe-protein, cytochrome c, with a calamitous new pro-oxidant function of a peroxidase. The latter triggers massive and lipotoxic lipid peroxidation. We propose three new types of potent and selective inhibitors of the peroxidase as potential new treatments for BTHS.

PI_NAMEs: BAYIR, HÜLYA ;GREENBERG, MIRIAM L;KAGAN, VALERIAN E (contact)

PROGRAM_OFFICER_NAME: BURNS, KRISTIN

PROJECT_TERMS: 3-Methylglutaconic aciduria type 2;Acylation;Bezafibrate;Binding;biochemical model;Biochemical Process;Biology;Cardiolipins;Cells;Cessation of life;Clinical Trials;clinically relevant;Code;Collaborations;Complex;cytochrome c;Cytochrome c Peroxidase;deacylation;Diagnosis;Disease;double-blind placebo controlled trial;Drug Targeting;effective therapy;Electron Transport;experimental study;Fatty Acids;Genes;Hemeproteins;Hydrogen Peroxide;Image;Imidazole;improved;inhibitor;Injury;Inner mitochondrial membrane;Lecithin;Ligand Binding;Ligands;Link;Lipid Peroxidation;lipidomics;Lipids;Mediating;Medicine;Membrane;Mitochondria;mitochondrial dysfunction;mitochondrial membrane;model organism;Modeling;Molecular Genetics;Mutate;Myopathy;Neutropenia;novel therapeutic intervention;Oleic Acids;Oxidants;Oxidation-Reduction;Pathogenesis;Pathogenicity;Pathology;Patients;Peroxidases;peroxidation;Pharmaceutical Preparations;Pharmacotherapy;Phosphatidylethanolamine;Phosphatidylinositols;Phospholipase;Phospholipids;Preclinical Testing;premature;prevent;Prevention;Proteins;Publishing;Quality of life;Reaction;Reactive Oxygen Species;Role;Site;skeletal;small molecule inhibitor;Source;Superoxides;Testing;Toxic effect;Transacylase;Unsaturated Fatty Acids;Whole Organism;X-Linked Genetic Diseases

PROJECT_TITLE: Selective inhibitors of MLCL/CytC Peroxidase in Barth Syndrome

STUDY_SECTION: DMPB

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology B Study Section[DMPB]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Coronaviruses;Emerging Infectious Diseases;Health Services;Infectious Diseases;Prevention

ORG_CITY: PROVIDENCE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: Project Narrative To respond to infectious disease outbreaks, public health officials require data about real-world, population- level effectiveness of potential interventions. This project will refine methods for policy evaluation with infectious disease outcomes, producing more accurate estimates of intervention effects, and use these to guide public health policies and planning.

PI_NAMEs: BILINSKI, ALYSSA  (contact)

PROJECT_TERMS: 2019-nCoV;Address;Adoption;Affect;analytical method;Architecture;Biological;Collaborations;Communicable Diseases;Complex;Computer software;COVID-19;Data;Disease;Disease Outbreaks;Disease Outcome;Ebola virus;Effectiveness;Effectiveness of Interventions;Future;Health Planning;Health Policy;HIV;improved;Influenza;innovation;Institution;interest;Intervention;intervention effect;Measures;Methodology;Methods;Modeling;Monkeypox;Morbidity - disease rate;mortality;open source;Outcome;pathogen;Play;Policies;Policy Analysis;Population;Population Dynamics;prospective;Public Health;respiratory;Role;SARS coronavirus;Specific qualifier value;Therapeutic;Time;tool;transmission process;treatment effect;Uncertainty;Update;Vaccines;Work

PROJECT_TITLE: Observational causal inference with infectious disease outcomes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MGG-D (55)]


ORG_CITY: ROCHESTER

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: PROJECT NARRATIVE The assembly states and secondary structures of biomolecules such as proteins and nucleic acids are crucial for their functions in biological processes. My research program leverages supramolecular chemistry to design new materials and structures that can interact with and modulate how biomolecules assemble and fold. Specifically, the work proposed here will develop synthetic, supramolecular chaperones to prevent protein aggregation and establish a platform for DNA and RNA targeting based on novel bifacial nucleobases, laying the foundation for future diagnostic and therapeutic interventions.

PI_NAMEs: PARTRIDGE, BENJAMIN EDWARD (contact)

PROJECT_TERMS: 3-Dimensional;Adopted;amphiphilicity;Amyloid beta-Protein;Architecture;Area;base;Base Pair Mismatch;Base Pairing;Base Sequence;Binding;Biological Process;capsule;Cell Differentiation process;Chemistry;Complex;cytotoxicity;design;Development;Diagnostic;DNA;Face;Foundations;Future;Genetic Transcription;Goals;Hydrophobicity;In Situ;Individual;Intercalating Agents;Interruption;Intervention;Length;Molecular Chaperones;molecular recognition;Molecular Structure;novel;Nucleic Acids;nucleobase;prevent;Process;programs;Property;protein aggregation;protein expression;protein folding;Protein Fragment;Proteins;Reaction;Research;RNA;scaffold;Series;small molecule;Structure;Structure-Activity Relationship;synthetic construct;Therapeutic;Therapeutic Intervention;Work

PROJECT_TITLE: Supramolecular Strategies to Modulate Biomolecular Folding and Assembly


NIH_SPENDING_CATS: Behavioral and Social Science;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Complementary and Integrative Health;Digestive Diseases;Mental Health;Pain Research;Rehabilitation

ORG_CITY: LOS ANGELES

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

ORG_STATE: CA

PHR: PROJECT NARRATIVE Irritable bowel syndrome (IBS) affects >10% of the US population and is characterized by chronic, recurrent abdominal pain and abnormal bowel habits that significantly impact health-related quality of life; current pharmacologic treatments, though, often fall short in delivering meaningful improvements in symptoms and are commonly limited by side effects. While cognitive behavioral therapy (CBT) is very effective and safe in IBS and endorsed in national guidelines, there is a paucity of CBT-trained clinicians in the US; to address this gap, we aim to conduct a pilot randomized controlled trial to collect preliminary data on the clinical impact and feasibility of a self-administered, home-based virtual reality (VR) CBT program that we developed vs. sham VR among patients with IBS. If this pilot study demonstrates that the VR CBT program is both feasible and meaningfully improves IBS symptoms, it will provide a strong platform to undertake an adequately powered, hypothesis-testing Phase II efficacy trial.

PI_NAMEs: ALMARIO, CHRISTOPHER V (contact)

PROGRAM_OFFICER_NAME: UNALP-ARIDA, AYNUR

PROJECT_TERMS: 3D world;Abdominal Pain;acceptability and feasibility;Address;Affect;American;Analgesics;Behavior Therapy;Behavioral;biopsychosocial;Brain;Chronic;Chronic Disease;Clinical;Clinical Trials;clinically significant;Cognitive;Cognitive Therapy;cognitive training;college;comorbidity;Congestive Heart Failure;COVID-19;Data;design;Development;Diabetes Mellitus;digital health;Disease;disorders of gut-brain interaction;Distress;Economics;effective therapy;efficacy trial;Emotional;End stage renal failure;Exercise Therapy;experience;Funding;Future;Gastroenterologist;Gastroenterology;Guidelines;Habits;head mounted display;health care service utilization;health related quality of life;High Prevalence;Home;human centered design;Image;implementation efforts;improved;improved outcome;Intestines;Irritable Bowel Syndrome;Medical;Mission;Modeling;multidisciplinary;National Institute of Diabetes and Digestive and Kidney Diseases;novel;Outpatients;Pain;pandemic disease;Participant;Patients;Perception;Persons;Pharmaceutical Preparations;pharmacologic;Pharmacological Treatment;Phase;phase 2 testing;Pilot Projects;Population;pre-pandemic;Prevalence;Problem Solving;programs;Psychiatrist;psychoeducation;psychologic;Psychologist;psychosocial;Randomized;Randomized, Controlled Trials;Recommendation;Recurrence;Relaxation;Research;Research Personnel;response;Risk;Self Administration;Severities;side effect;skills;Specialist;Symptoms;Techniques;Telephone;Testing;Therapeutic;Training;trial comparing;United States Food and Drug Administration;Validation;virtual reality;Visit;Visualization

PROJECT_TITLE: Clinical Impact and Feasibility of Virtual Reality (VR) for Irritable Bowel Syndrome: A Pilot Randomized Controlled Trial Comparing VR Cognitive Behavioral Therapy vs. Sham VR

STUDY_SECTION: BMHO

STUDY_SECTION_NAME: Biobehavioral Medicine and Health Outcomes Study Section[BMHO]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

ORG_STATE: MA

PHR: Project Narrative  Alzheimer’s disease (AD) and other neurodegenerative diseases are characterized by age-associated neuronal loss, which involves neuroinflammation induced by reactive microglia. Our preliminary analyses from three AD cohorts and with three sequencing technologies consistently revealed an excess of clonal somatic mutations in AD brains, particularly in proliferation-related genes of microglia. We plan to test our hypothesis that the accumulation of somatic mutation contributes to an age-related increase in AD risk by driving the clonal expansion of microglia, which subsequently induces neuroinflammation and neuronal loss in AD brains.

PI_NAMEs: HUANG, YUE  (contact)

PROGRAM_OFFICER_NAME: GRAY, ERIN EMILY

PROJECT_TERMS: 3-Dimensional;Age;age related;Aging;aging process;Alleles;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease patient;Alzheimer's disease risk;Automobile Driving;Autopsy;Bar Codes;Benchmarking;Bioinformatics;Biological Assay;Blood Cells;BRAF gene;Brain;brain control;Brain region;Cancer Etiology;cancer risk;Cardiovascular Diseases;Cell Cycle;Cell Nucleus;Cell Proliferation;cell type;Cells;Central Nervous System;Clinic;Clonal Expansion;Code;cohort;Collection;Copy Number Polymorphism;Data;Data Analyses;Development;differential expression;Disease associated microglia;Environment;Gene Expression;Genes;Genetic;Hematologic Neoplasms;Histiocytosis;Human;Human body;human stem cells;Immune;Impaired cognition;in silico;In Vitro;Inflammatory;insertion/deletion mutation;knock-down;large datasets;Link;Mediating;Methods;Microglia;Modeling;mouse model;mutant;Mutate;Mutation;Nerve Degeneration;Nervous System Disorder;Neurodegenerative Disorders;neuroinflammation;neuron loss;Neurons;novel;pathogen;Pathogenesis;Pathway interactions;Patients;Phagocytosis;Play;Population;Prevalence;Proliferating;Recurrence;Reporting;response to injury;Risk;Role;Sampling;sex;Single Nucleotide Polymorphism;single nucleus RNA-sequencing;single-cell RNA sequencing;Somatic Mutation;Sorting;stem cell differentiation;Technology;Testing;Tissue-Specific Gene Expression;transcriptome;transcriptome sequencing;Up-Regulation;Validation

PROJECT_TITLE: Role of clonal somatic mutations in microglia and Alzheimer’s disease

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


NIH_SPENDING_CATS: Biotechnology;Lung;Pulmonary Fibrosis;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Chronic lung diseases including chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis are a significant healthcare burden in the US and small airways are often the sites of damage in these diseases. In this proposal we seek to obtain a mechanistic understanding of epithelial regeneration in these regions and these results will assist in developing effective therapies to regenerate small airways in chronic lung diseases.

PI_NAMEs: KADUR LAKSHMINARASIM, PREETISH  (contact)

PROGRAM_OFFICER_NAME: LU, QING

PROJECT_TERMS: Address;Affect;Air;airway obstruction;airway regeneration;Alveolus;Anatomy;Bar Codes;Basal Cell;Binding Sites;Biology;Black Box;Cell Culture Techniques;Cell Differentiation process;Cell Physiology;cell type;Cells;Chronic lung disease;Chronic Obstructive Pulmonary Disease;Cleavage Under Targets and Release Using Nuclease;Clustered Regularly Interspaced Short Palindromic Repeats;Coupled;Data;Diameter;Disease;Distal;Duct (organ) structure;effective therapy;Epithelium;epithelium regeneration;experimental study;Ferrets;Fibrosis;Gene Expression Regulation;Genes;Genetic Transcription;Genome;Goals;Health;healthcare burden;Homeostasis;Human;human stem cells;Hybrid Cells;idiopathic pulmonary fibrosis;Immunocompromised Host;Immunoprecipitation;in vivo;Inflammation;Injury;Lesion;Liquid substance;Lung;Lung Diseases;Maps;meter;Microdissection;model organism;Modeling;Molecular;Mucous body substance;Mus;Natural regeneration;novel;Outcome;Pathology;Patients;Pattern;Population;Production;progenitor;programs;Property;Protocols documentation;Pulmonary Fibrosis;Regulation;respiratory;Secretory Cell;self-renewal;Seminal;Site;small airways disease;stem cell population;stem cells;stoichiometry;Structure of respiratory bronchiole;Terminal Bronchiole;Testing;transcription factor;transcriptomics;Xenograft procedure

PROJECT_TITLE: Regulation of distal basal cells in terminal and respiratory airway regeneration

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 RCCS-B (03)]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Neurosciences;Pediatric;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Project Narrative Communal living and cooperative behavior can help ensure group success, the health and well-being of adults and children, and survival of the species. Perhaps the single most important brain system for pro-social behavior and parenting is the hypothalamic oxytocin neuron population, but little is known about how oxytocin neurons respond during group interactions, including in complex outdoor environments. The experiments to be performed in this proposal provide essential data on neural activity during collective behavior of groups of mice first studied in the lab and then examined in the outdoor Stony Ford field station, including a focus on oxytocin for social hierarchy formation, foraging, burrow building, and co-parenting.

PI_NAMEs: FROEMKE, ROBERT CROOKS (contact);GRAHAM, ANDREA L.

PROGRAM_OFFICER_NAME: DAVID, KAREN KATE

PROJECT_TERMS: Adult;Affect;Aggressive behavior;Algorithms;Animal Behavior;Animals;Automobile Driving;Behavior;Behavior monitoring;Behavioral;Biological Assay;Brain;BRAIN initiative;Brain region;Caring;cell type;Cells;Child;Child Rearing;Climacteric;Collaborations;commune;Complex;Cooperative Behavior;Coupled;Crying;Data;Data Analyses;Data Collection;Development;Ecology;Ecosystem;Ensure;Environment;environmental stressor;experience;experimental study;Family;feeding;Feeding behaviors;Female;Food;Gene Expression;Goals;Grooming;Health;Hour;Housing;Hunger;Hyperthermia;Hypothalamic structure;Image;in vivo;Infant;Knockout Mice;Laboratory mice;large datasets;Life;male;mature animal;Measures;Methodology;Methods;Monitor;Motion;Multimodal Imaging;Mus;neural;neural circuit;neurobehavioral;Neurons;Neurosciences;Nulliparity;offspring;Optics;optogenetics;Oxytocin;paraventricular nucleus;Parents;Pattern;Personal Satisfaction;Physiological;Population;Pregnancy;preservation;pup;recruit;Regulation;Resolution;response;Role;Same-sex;Shapes;Site;skills;social;social engagement;Social Hierarchy;Social Interaction;Social Network;Structure;success;System;Technology;Temperature;Territoriality;Testing;Time;Tube;Volatilization;Water;wireless;Women's Group;Work

PROJECT_TITLE: Hypothalamic activity and collective mouse behavior in lab cages vs outdoor colonies

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 ICN-D (55)]


ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative Improper cell division is linked to developmental defects and cancers. A critical irreversible step in cell division is the precise positioning of the cell cleavage site to form two equal daughter cells. Here we examine how an essential mitotic kinase, which is required for proper completion of cell division, finds the cell center. Our findings will uncover fundamental mechanisms underlying error-free cell division and has the potential to uncover new therapeutic strategies for targeting cell division.

PI_NAMEs: SUBRAMANIAN, RADHIKA  (contact)

PROJECT_TERMS: Address;Amino Acids;Anaphase;Aneuploidy;Atomic Force Microscopy;aurora B kinase;Binding;Biochemical;Biochemistry;Biological Assay;biophysical techniques;Biophysics;borealin;Cell division;Cells;Centromere;Chimera organism;chromosome missegregation;Chromosomes;Complex;Cryoelectron Microscopy;Cues;Cytokinesis;Cytoplasm;Cytoskeleton;Data;daughter cell;Defect;Dependence;design;Development;Dissociation;Ensure;Failure;Future;genome integrity;Goals;Grant;Human;Human Chromosomes;In Vitro;inner centromere protein;insight;Kinesin;Knowledge;Length;Link;Malignant Neoplasms;mechanical properties;microscopic imaging;Microtubule Bundle;Microtubule-Associated Proteins;Microtubules;Mitotic;Mitotic spindle;Modeling;Molecular;Molecular Conformation;Motor;mutant;nanometer;novel therapeutic intervention;Peptides;Phosphorylation;Phosphotransferases;physical separation;Play;Positioning Attribute;Process;Property;protein complex;Proteins;quantitative imaging;Radial;Reaction;Recombinants;reconstitution;Research;Role;Scaffolding Protein;Series;Signal Transduction;Signaling Protein;Site;Specific qualifier value;Spectrum Analysis;Speed;Structure;survivin;System;Testing;Therapeutic;Time;Total Internal Reflection Fluorescent;tumorigenesis;Visualization;Work

PROJECT_TITLE: Mechanisms of spindle organization for cell division

STUDY_SECTION_NAME: Cell Structure and Function 1 Study Section[CSF1]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering

ORG_CITY: RICHMOND

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: PROJECT NARRATIVE Collective migration, when cells migrate as an entire unit, is the foundation not only for successful development of many tissues but also dysregulation in collective migration is a hallmark for development abnormalities or disease progression. Our understanding of collective migration, especially the mechanics and mechanisms driving this phenomenon is very limited and thus the objective of this proposal. Our proposal will significantly accelerate our progress towards a comprehensive understanding of collective migration and lay the foundation for advancing treatment for developmental abnormalities or diseases.

PI_NAMEs: HWANG, PRISCILLA Y (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TERMS: Acceleration;Automobile Driving;Biological Process;Biomechanics;Cell Communication;cell motility;cell type;Cells;Cues;Development;Devices;Disease;Disease Progression;Environment;experimental study;Extracellular Matrix;Fluorescence Resonance Energy Transfer;Foundations;Goals;Intercellular Junctions;interest;knock-down;Measures;mechanical force;mechanical signal;Mechanics;mechanotransduction;Microfluidic Microchips;Microfluidics;migration;Neoplasm Metastasis;prevent;Research Design;Role;sensor;Series;Signal Transduction;success;Time;Tissues;wound healing

PROJECT_TITLE: Dissecting mechanisms of collective migration


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: Project Narrative Almost every cell in an individual has the same DNA sequence yet vary greatly in the chemical modifications on DNA called epigenetics that can give rise to different cell types. Failure to regulate the epigenetic content of human cells is a hallmark of aging, cancer cells, and many human diseases. My research aims to understand how epigenetic modifications are established on the human genome and to understand how aberrant epigenetic patterns in human DNA can lead to disease states.

PI_NAMEs: NUNEZ, JAMES KARLO (contact)

PROGRAM_OFFICER_NAME: CHOW, CHI-WING

PROJECT_TERMS: Aberrant DNA Methylation;Biochemistry;Biology;cancer cell;cancer immunotherapy;cancer stem cell;Cell Therapy;cell type;Cells;Chemicals;clinical application;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;CRISPR/Cas technology;Defect;Disease;DNA;DNA Methylation;DNA Sequence;DNA sequencing;DNA Transposable Elements;embryonic stem cell;Engineering;epigenetic memory;Epigenetic Process;Failure;gene discovery;Gene Expression;gene therapy;Genes;Genetic;Genetic Code;Genetic Screening;Genetic Transcription;Genome;genome editing;genome-wide;Genomic Imprinting;Goals;hallmarks of aging;Human;human disease;human DNA;Human Genome;Immune;Individual;innovation;interdisciplinary approach;Laboratories;Laboratory Research;methylation pattern;Modification;next generation;Pathway interactions;Pattern;programs;Proteins;Research;RNA-Binding Proteins;Role;Science;Site;Technology;tool;Writing;X Inactivation

PROJECT_TITLE: Mechanisms of epigenetic memory in human cells

STUDY_SECTION_NAME: Maximizing Investigators' Research Award - F Study Section[MRAF]


ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative: Decisions of fate for an activated cell are complex processes that are tightly regulated in the human body to ensure organ functionality while safeguarding against deleterious consequences of uncontrolled cell proliferation or death. One such mechanism, namely the metabolic clock operates as a countdown to self-destruction through metabolic instability, which is initiated when a cell receives an activation signal and can only be defused by receiving secondary signals validating the initial stimulus. Our proposed studies will elucidate the mechanistic underpinnings of the metabolic clock and identify molecular targets that can be used for generating novel therapeutics against disorders stemming from errors in cell fate decision processes, including degenerative diseases, malignancies and autoimmune conditions.

PI_NAMEs: AKKAYA, MUNIR  (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TERMS: Address;antigen binding;Autoimmune Diseases;Autoimmunity;B-Cell Antigen Receptor;B-Lymphocytes;Biochemical;Bone Marrow;Calcium;Cell Cycle;Cell Death;Cell Proliferation;Cell Survival;cell type;Cells;Cellular Assay;Cessation of life;Chimera organism;Complex;Cytoplasm;Degenerative Disorder;Disease;Ensure;Epigenetic Process;Equilibrium;Functional disorder;Goals;Homeostasis;Human;Human body;in vivo Model;Life;Malignant Neoplasms;Metabolic;Metabolic Pathway;Metabolism;Mitochondria;mitochondrial dysfunction;Modeling;Molecular;Molecular Target;mouse model;Neoplasms;novel;novel therapeutic intervention;novel therapeutics;Organ;Outcome;pathogen;Pathway interactions;Play;prevent;Process;Production;Proliferating;Research;Role;Sampling;Signal Transduction;Signaling Molecule;spatiotemporal;stem;Stimulus;T-Lymphocyte;Toll-like receptors;Transgenic Mice;Work

PROJECT_TITLE: The metabolic clock as a regulator of cell fate decision

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


NIH_SPENDING_CATS: Aging;Dietary Supplements

ORG_CITY: WINSTON-SALEM

ORG_NAME: WAKE FOREST UNIVERSITY

PHR: Project Narrative The proposed research is relevant to public health because fundamental studies aimed at exploring chemical biology and medicinal chemistry of reactive sulfur and selenium species is likely to open new and innovative avenues for therapeutic intervention. The proposed program aligns with the mission of NIH as it will expand the knowledge base to address the causes, diagnosis, prevention, and cure of human diseases.

PI_NAMEs: LUKESH, JOHN CARL (contact)

PROJECT_TERMS: Address;age related;Alzheimer's Disease;anticancer activity;Attention;Biological;Biology;Blood Vessels;Cardiovascular system;Chemicals;Chemistry;Chemoprotective Agent;Communities;Detection;Development;Diagnosis;Diagnostic;Disease;Drug Design;Half-Life;Health;hormone regulation;Human;human disease;human model;Hydrogen;Hydrogen Sulfide;improved;innovation;interest;knowledge base;Malignant Neoplasms;member;Mission;Monitor;neuroprotection;novel;novel therapeutic intervention;novel therapeutics;Organelles;Parkinson Disease;Pathology;Patient Self-Report;persulfides;Pharmaceutical Chemistry;Play;polysulfide;Pre-Clinical Model;Prevention;Production;programs;Property;protective effect;Public Health;Reaction;Relaxation;Research;Role;Selenium;sensor;small molecule;Sulfur;Supplementation;theranostics;Therapeutic;Therapeutic Intervention;trafficking;United States National Institutes of Health;Work

PROJECT_TITLE: Biomedical Applications of Reactive Sulfur and Selenium Species: Diagnosis and Therapuetics


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: TUCSON

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: PROJECT NARRATIVE This proposal utilizes a family-based approach to address how culturally-relevant family relationship dynamics among Latinx sexual and gender minority (SGM) adolescents and their parents inform health inequalities. A new parallel adolescent-report measure of Latinx parent acceptance will be developed to work with an existing parent- report measure of Latinx parent acceptance of their SGM adolescents; this new measure – along with other key indicators of general and SGM-specific family relationships and structural and social determinants of health will be studied as predictors of family mental health. The new dyadic tool and intersectional approach will provide novel information to develop culturally-relevant, family-based interventions to reduce health disparities among Latinx SGM adolescent populations.

PI_NAMEs: ABREU, ROBERTO LUIS;GATTAMORTA, KARINA ;TOOMEY, RUSSELL BLAKE (contact)

PROGRAM_OFFICER_NAME: GARRIDO, CARLOS OSWALDO

PROJECT_TERMS: Address;Adolescent;Age;Anxiety;anxiety symptoms;Area;Arizona;Belief;Characteristics;cisgender;Clinical;Communities;coping;Counseling;Cultural Backgrounds;cultural values;Delphi Study;depressive symptoms;design;Destinations;Development;Discrimination;Disparity;disparity reduction;Emotional;Ensure;ethnic minority population;Ethnic Origin;experience;Family;Family health status;family influence;Family member;Family Process;Family Relationship;Feeling suicidal;Florida;Focus Groups;Future;Gender;gender minority;gender minority health disparity;gender minority youth;Goals;Health;Health Disparities Research;health inequalities;Health Resources;Homo;Immigrant;Individual;innovation;interest;Intervention;Investigation;Knowledge;knowledge base;Latinx;Link;Literature;Measurement;Measures;member;Mental Depression;Mental Health;Methods;Modeling;National Institute on Minority Health and Health Disparities;nonbinary;novel;Outcome;Parents;Personal Satisfaction;PhenX Toolkit;Population;Process;promote resilience;Property;protective factors;Provider;Psychology;Psychometrics;racial minority population;recruit;Reduce health disparities;Reporter;Reporting;Research;Research Design;Research Personnel;resilience;response;Risk;Risk Reduction;Sampling;Science;Sexual and Gender Minorities;sexual minority;sexual minority youth;Sexuality;social;social determinants;social health determinants;Social Processes;Social support;Stress;stressor;structural determinants;suicidal behavior;System;Testing;therapy development;tool;Work

PROJECT_TITLE: Mental Health Risk and Resilience among Latinx SGM Adolescents and their Parents

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


NIH_SPENDING_CATS: Genetics;Kidney Disease

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

PHR: Project narrative Nuclear receptors regulate a myriad of genetic programs to control metabolism, inflammation, and development in a precise spatiotemporal manner. In this project, we seek to determine molecular mechanisms by which these multi-domain nuclear receptors act, focusing on the emerging roles of the highly disordered domains and allosteric communications between folded domains. Understanding the molecular basis of these regulation mechanisms will help to understand and treat many human disorders ranging from cardiovascular to metabolic diseases.

PI_NAMEs: LIU, XU  (contact)

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TERMS: Adipose tissue;Androgen Receptor;antagonist;Biological Process;biophysical techniques;Brain;C-terminal;cardiovascular disorder therapy;Cardiovascular system;chromatin modification;Communication;Development;Disease;Distal;DNA Binding Domain;DNA Sequence;Electrolytes;Enzymes;Epithelial Cells;Estrogen Receptors;Family;Fibrosis;Future;Gene Expression;Genetic;Genetic Transcription;Glucocorticoid Receptor;Goals;Heart;Homeostasis;Homologous Gene;Human;Individual;Inflammation;Kidney;Kidney Diseases;Knowledge;Laboratories;Length;Ligand Binding Domain;Ligands;Liquid substance;Liver;Mediating;member;Metabolic Diseases;Metabolism;Mineralocorticoid Receptor;Molecular;N-terminal;Nephrons;Nuclear Receptors;Oxidative Stress;Phase;Physical condensation;Play;programs;recruit;Regulation;Reproduction;Role;spatiotemporal;structural biology;System;Tissues;transcription factor

PROJECT_TITLE: Multifaceted Regulation of Mineralocorticoid Receptor Transcriptional Activities


NIH_SPENDING_CATS: Aging;Hematology;Neurosciences;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

ORG_STATE: NY

PHR: PROJECT NARRATIVE The microenvironment of the bone marrow plays a critical role in regulating stem cell activity and has a significant role in mediating stem cell aging and the development of age-related blood disorders. This project seeks to understand how the autonomic nervous system controls components of the stem cell niche to regulate aging of the blood system.

PI_NAMEs: MARIANOVICH, MARIA  (contact)

PROGRAM_OFFICER_NAME: BAI, C BRIAN

PROJECT_TERMS: Acceleration;Adrenergic Agents;Adrenergic Agonists;Adrenergic Receptor;age related;aged;Aging;Agonist;Appearance;Autonomic nervous system;Biological;Blood;Blood Vessels;Bone Marrow;bone marrow mesenchymal stem cell;Cell Aging;Cell Communication;Cell Culture System;Cell Culture Techniques;Cell Maintenance;Cell membrane;cell type;Cells;Cellular Metabolic Process;circadian;Circadian Rhythms;Clinical;Coculture Techniques;Complex;Connexin 43;Connexins;Data;Deterioration;Development;Discontinuous Capillary;Disease;Elderly;Exhibits;experimental study;Gap Junctions;Generations;Genetic;glucose metabolism;Hematological Disease;Hematopoietic;hematopoietic stem cell aging;Hematopoietic Stem Cell Mobilization;hematopoietic stem cell niche;Hematopoietic stem cells;Hematopoietic System;Hemorrhage;Homeostasis;immune function;improved;In Vitro;Individual;Mediating;Mesenchymal Stem Cells;Metabolic;migration;Mitochondria;mitochondrial metabolism;Molecular;Mus;Myelogenous;Myeloproliferative disease;NADPH Oxidase;Nerve;nerve supply;Nervous System control;neural model;neuromechanism;Neuropathy;neurotransmission;novel;novel strategies;old mice;Output;Oxidation-Reduction;Pathway interactions;Periodicity;peripheral blood;pharmacologic;Phenotype;Play;premature;prevent;Production;progenitor;Reactive Oxygen Species;Regenerative capacity;Regulation;Rejuvenation;Role;self-renewal;Series;Signal Transduction;single-cell RNA sequencing;stem;stem cell aging;stem cell function;stem cell homeostasis;stem cell niche;stem cells;Stromal Cell-Derived Factor 1;Stromal Cells;Superoxides;Supplementation;Sympathetic Nervous System;System;Testing;Therapeutic;trafficking;transmission process

PROJECT_TITLE: Regulation of hematopoietic stem cell niche aging by the sympathetic nervous system

STUDY_SECTION: HTBT

STUDY_SECTION_NAME: Hemostasis, Thrombosis, Blood Cells and Transfusion Study Section[HTBT]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Digestive Diseases;Liver Disease;Orphan Drug;Rare Diseases;Regenerative Medicine;Transplantation

ORG_CITY: SCOTTSDALE

ORG_NAME: MAYO CLINIC ARIZONA

PHR: PROJECT NARRATIVE Off-the-shelf engineered cells secreting therapeutic proteins is an attractive approach for treating chronic diseases such as hemophilia, diabetes, and liver disorders. However, poor survival and dysfunction within the in vivo environment limit their clinical translation. My lab will use bioengineering strategies to design cells and implants better suited for long-term survival and durable functioning at the target organ in vivo.

PI_NAMEs: BOSE, SUMAN  (contact)

PROGRAM_OFFICER_NAME: KODURI, SAILAJA

PROJECT_TERMS: Attention;Biological;Biomedical Engineering;Black Box;cell behavior;Cell Death;Cell Physiology;Cell secretion;Cell Therapy;Cell Transplantation;Cells;cellular engineering;cellular resilience;Cessation of life;Chronic Disease;clinical translation;combat;Cues;design;Devices;Diabetes Mellitus;Disease;Encapsulated;Engineering;Environment;Fibrosis;Foreign-Body Reaction;Functional disorder;Future;Goals;Heart;Hemophilia A;Homologous Transplantation;Human;Hypoxia;Immune system;immunogenic;immunogenicity;Immunosuppression;Implant;improved;in vivo;inflammatory milieu;innovation;Knowledge;Liver;Liver diseases;multidisciplinary;Organ;Pathway interactions;Pharmaceutical Preparations;programs;Research;System;Therapeutic;therapeutic protein

PROJECT_TITLE: Engineering cell-based therapy for enhanced survival and durable function in vivo

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MBBC-F (55)]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Depression;Mental Health;Mental Illness;Neurosciences

ORG_CITY: ITHACA

ORG_NAME: CORNELL UNIVERSITY

PHR: PROJECT NARRATIVE Classical psychedelics such as psilocybin are being investigated as potential treatment for major depression. It is known that psilocybin can induce neural plasticity in the neocortex, however the brain region contains many different cell types and how they may interact to mediate drug action is not known. This proposal seeks to address this knowledge gap, which can provide insights into the neurobiology of psilocybin and may lead to better treatments for depression.

PI_NAMEs: KWAN, CHUN-HAY ALEX  (contact)

PROGRAM_OFFICER_NAME: NADLER, LAURIE SUE

PROJECT_TERMS: Acute;Address;awake;Behavior;Behavioral;behavioral phenotyping;Binding;Biology;Brain region;Calcium;cell type;Cells;Clinical Trials;conditional knockout;Cre driver;Data;Dependence;Dose;drug action;Electrophysiology (science);Experimental Designs;experimental study;Extinction;Fright;frontal lobe;Genetic;Goals;Hallucinogens;Head;HTR2A gene;Image;in vivo;insight;interest;Interneurons;Knock-out;Knowledge;Learned Helplessness;Major Depressive Disorder;Measures;Medial;Mediating;Mental Depression;Mental disorders;Mouse Strains;Mus;Neocortex;neural;Neurobiology;Neuronal Plasticity;Neurons;optical imaging;Outcome;Parvalbumins;Patients;Pharmaceutical Preparations;Psilocybin;Psychotherapy;Pyramidal Cells;receptor;receptor expression;reduce symptoms;Research;response;Role;serotonin receptor;Serotonin Receptor 5-HT1A;Serotonin Receptor 5-HT2A;Serotonin Receptor 5-HT2C;Shapes;Slice;Somatostatin;Stress;Testing;Therapeutic;Therapeutic Effect;tool;transcriptomics;two-photon;Vasoactive Intestinal Peptide

PROJECT_TITLE: Role of cortical GABAergic interneurons in psychedelic drug action

STUDY_SECTION: MCNP

STUDY_SECTION_NAME:
Molecular and Cellular Neuropharmacology Study Section
[MCNP]


NIH_SPENDING_CATS: Bioengineering;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Nutrition;Prevention

ORG_CITY: PORTLAND

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Title: Advancing computational modeling of disease metabolism by integrating AI and systems biology Project Narrative: The goal of this project is to design and implement an omics-centric framework to systematically delineate metabolic variations and their implications in complex disease, by leveraging advanced data-driven and AI- enhanced systems biology methodologies. Specifically, we will harness the power of multi-omics data to innovatively characterize metabolic landscapes, quantify metabolic shifts, mechanistically decode the impact of metabolic variations, and advance precision medicine, through novel computational tools, metrics, and a public knowledge base. This project promises transformative insights into metabolic dysregulation underpinning the complex disease pathology, which is directly relevant to the missions of NIGMS to improve fundamental principles and mechanisms underlying living organisms.

PI_NAMEs: CAO, SHA  (contact)

PROJECT_TERMS: Address;Area;Artificial Intelligence enhanced;Biochemical;Biology;Biophysics;Cardiovascular Diseases;Cells;clinical diagnostics;Complex;Computer Models;computerized tools;Data;design;Development;Diabetes Mellitus;Diet;dietary;Disease;disease model;early detection biomarkers;Early Diagnosis;Early treatment;Goals;Health;Heterogeneity;Immune response;improved;Inflammatory;innovation;insight;Intervention;Knowledge;knowledge base;Literature;Malignant Neoplasms;Medical;Metabolic;metabolic abnormality assessment;Metabolic Pathway;metabolic phenotype;Metabolism;Methodology;Mission;Modeling;Multiomic Data;National Institute of General Medical Sciences;Natural Language Processing;neural network;Neurodegenerative Disorders;new therapeutic target;novel;Nutrient;Nutritional;Organism;Pathology;Patients;Population;precision medicine;Prevention;Recommendation;Research;response;Role;System;Systems Biology;Tissues;tool;Transcriptional Regulation;treatment optimization;Validation;Variant


NIH_SPENDING_CATS: Complementary and Integrative Health;Microbiome;Nutrition

ORG_CITY: DENVER

ORG_NAME: UNIVERSITY OF DENVER (COLORADO SEMINARY)

ORG_STATE: CO

PHR: Project Narrative The composition and function of the human microbiota is significantly influenced by access to key metal micronutrients, including iron, copper, zinc, and cobalt, because microorganisms must compete with one another for limited resources. Although mechanisms and effects of metal competition have been extensively studied in metal-limited environmental systems, how the human microbiota acquires metals through the production of metallophores, small-molecule natural products that bind metals with high affinity and selectivity, remains underexplored due to various analytical, chemical, and biological challenges. The goal of this proposal is to elucidate the structure and functions of microbially-derived metallophores as modulating microbe-microbe and community interactions within human microbiomes; not only will this contribute fundamental chemical and microbiological knowledge, but can also enable targeted modulation of the microbiota and precision medicine approaches.

PI_NAMEs: ARON, ALLEGRA  (contact)

PROJECT_TITLE: Microbiota Metallophores: Probing Interactions and Nutrient Dynamics of the Human Gut

STUDY_SECTION_NAME: Maximizing Investigators' Research Award - E Study Section[MRAE]


ADMINISTERING_IC: HS

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: TEMPE

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

PHR: PROJECT NARRATIVE The proposed project will develop and evaluate an online contraceptive decision aid for the transgender and gender-nonconforming (TGNC) individuals assigned female at birth (AFAB). It will generate evidence to use digital health interventions to improve gender-minority groups’ health. The project has long-term potential impacts to advance health and healthcare equity.

PI_NAMEs: WANG, DONGWEN  (contact)

PROGRAM_OFFICER_NAME: CHEW, EMILY

PROJECT_TITLE: Development and Evaluation of an Online Contraception Decision Aid for Transgender and Gender-Nonconforming (TGNC) Persons Assigned Female at Birth (AFAB)

STUDY_SECTION: HITR

STUDY_SECTION_NAME: Healthcare Information Technology Research[HITR]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Disorders;Intellectual and Developmental Disabilities (IDD);Lymphatic Research;Nanotechnology;Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

PHR: Project Narrative Gaucher disease is a common inherited lysosomal storage disease affecting 1 in 500 in Ashkenazi Jews and 1 in 60,000 in the general population. Available enzyme treatment is adequate for the form of the disease affecting organs outside the brain, but a highly lethal central nervous system subtype, unfortunately, lacks any effective therapy, primarily because current enzyme treatments do not cross the blood-brain barrier. We have developed a therapeutic approach utilizing a more stable enzyme linked to Saposin C-based nanovesicles that can cross through the blood-brain barrier, allowing delivery of the replacement enzyme into the brain and promising an effective treatment.

PI_NAMEs: QI, XIAOYANG ;SUN, YING  (contact)

PROGRAM_OFFICER_NAME: MORRIS, JILL A

PROJECT_TERMS: Affect;Amino Acids;Ashkenazim;Autophagocytosis;beta-Glucosidase;beta-Glucosidase Stimulating Protein;Binding;Biodistribution;Biological;Biotechnology;Blood - brain barrier anatomy;Blood coagulation;blood-brain barrier crossing;blood-brain barrier penetration;bone;Brain;Brain Diseases;brain tissue;Cell membrane;Cell Physiology;Cell surface;Cells;Central Nervous System;Central Nervous System Diseases;Circulation;Clinical Trials;cost;Disease;disease model;Disease Outcome;disorder subtype;disulfide bond;Dose;Drug Kinetics;effective therapy;Effectiveness;efficacy evaluation;enzyme replacement therapy;Enzyme Stability;Enzymes;FRAP1 gene;Gaucher Disease;General Population;Genes;glucosylceramidase;Glucosylceramides;glucosylsphingosine;Glycolipids;Half-Life;Hepatosplenomegaly;Hour;Human;Impairment;improved;improved outcome;induced pluripotent stem cell;Inherited;Intraperitoneal Injections;Intravenous;Intravenous infusion procedures;intravenous injection;Kinetics;Link;lymph nodes;Lymphatic;lymphatic circulation;Lymphatic System;lymphatic vessel;Lysosomal Storage Diseases;Lysosomes;Mediating;Meninges;Midbrain structure;Mitochondria;Modeling;mouse model;Mus;Mutation;Names;nanocarrier;nanodrug;nanovesicle;Nerve Degeneration;Neurologic;Neuronopathic Gaucher Disease;Neurons;novel;Organ;Organoids;Pathway interactions;patient derived induced pluripotent stem cells;Patients;Penetration;Peptide Hydrolases;Phenotype;Phosphatidylserines;Plasma;preclinical study;prevent;Process;Property;receptor;Regimen;Role;Route;Secondary to;Serine;Signal Transduction;System;Testing;Therapeutic;Tissues;Transgenic Mice;uptake;Visceral

PROJECT_TITLE: Systemic Enzyme Delivery by a Brain Targeted SapC-DOPS Nanocarrier for Treatment of Neuronopathic Gaucher Disease

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


NIH_SPENDING_CATS: Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: Princeton

ORG_NAME: PRINCETON UNIVERSITY

ORG_STATE: NJ

PHR: Project Narrative  Biomolecular condensates are intracellular structures that organize cellular components into “membraneless organelles,” which play essential roles in a wide range of biological processes including gene transcription, protein translation, and cell signaling. This research program will determine the biochemical features of protein/RNA molecules that govern the molecular compositions and assembly mechanisms of biomolecular condensates, allowing us to connect changes in protein/RNA sequences to changes in membraneless compartmentalization within the complex intracellular environment. By leveraging modern simulation and machine-learning methods, our work will (1) provide vital insights into the mechanisms that cells use to control condensate assembly and composition, (2) introduce sequence design tools for engineering protein/RNA molecules to regulate condensate assembly and composition, and (3) lay the groundwork for future therapeutic strategies based on manipulating this form of intracellular spatial organization.

PI_NAMEs: JACOBS, WILLIAM MONROE (contact)

PROGRAM_OFFICER_NAME: GERSHENSON, ANNE

PROJECT_TERMS: Amino Acid Sequence;Biochemical;Biochemical Reaction;Biological Process;Biophysical Process;Biophysics;Cells;Chromatin;Chromatin Modeling;Complex;Computer Models;computer studies;Computing Methodologies;Data;design;Environment;Future;Genetic Transcription;histone modification;in vivo;innovation;insight;Kinetics;learning strategy;Liquid substance;Location;Machine Learning;machine learning method;machine learning model;Maps;Membrane;Modeling;models and simulation;Modernization;Molecular;Neurodegenerative Disorders;Nuclear;Nucleic Acids;Organelles;organizational structure;Pathologic;Pathway interactions;Phase;Physical condensation;Play;Process;programs;Protein Biosynthesis;Protein Engineering;Proteins;Regulation;Research;RNA;RNA Sequences;Role;self assembly;Signal Transduction;simulation;Structure;Subcellular structure;success;Techniques;Theoretical Studies;theories;Therapeutic;Thermodynamics;tool;transcription factor;Translations;Virus Replication;Work

PROJECT_TITLE: Molecular determinants of condensate assembly in heterogeneous environments

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Depression;Mental Health;Neurosciences;Nutrition;Women's Health Research

ORG_CITY: DURHAM

ORG_DEPT: PSYCHOLOGY

ORG_NAME: DUKE UNIVERSITY

PHR: Narrative Decades of research have strongly linked disruptions in the serotonin (5HT) system to mental health disorders such as depression, and social and communication difficulties. Microglia colonize the developing dorsal raphe nucleus (DRN) where 5HT cell bodies are localized starting as early as embryonic day (E)10 and thus are likely to shape this brain region as it develops. Our data point to microglia as a critical effector cell between maternal inflammatory signals in response to a high fat diet and subsequent neural development, which we examine in this proposal.

PI_NAMEs: BILBO, STACI D (contact)

PROGRAM_OFFICER_NAME: TONELLI, LEONARDO HERALDO

PROJECT_TERMS: Address;Adult;Affective;Anhedonia;Apoptosis;Automobile Driving;Bathing;Behavior;Behavioral;behavioral health;behavioral outcome;Brain;Brain region;brain shape;Cell Proliferation;Cells;Color;Communication difficulty;conditional knockout;Data;density;Development;Diet;Dietary Intervention;Disease;Dorsal;dorsal raphe nucleus;Effector Cell;Embryo;Endotoxins;Environment;Etiology;Excision;Exhibits;Female;fetal;fetal programming;Fiber;Fluorescence;Gene Expression Profile;Goals;Heterogeneity;High Fat Diet;Hyperphagia;Image;Immune;Immune response;Immunologic Receptors;In Situ;Inflammation;Inflammatory;Life;Link;male;Measurement;Measures;Mental Depression;Mental disorders;Microglia;migration;mother nutrition;Mus;neural circuit;neurodevelopment;Neurons;neurotransmission;Neurotransmitters;Nucleus Accumbens;offspring;Outcome;Pattern;Phagocytes;Phagocytosis;Placenta;Population;Predisposition;preference;Pregnancy;prevent;receptor;Research;response;Rewards;Role;saturated fat;Serotonin;sex;Sex Differences;Shapes;Signal Transduction;single molecule;single-cell RNA sequencing;Slice;social;social deficits;Stimulus;stressor;Sucrose;Supplementation;System;Testing;Time;TLR4 gene;Translating;Tryptophan;women versus men;Work

PROJECT_TITLE: Microglial-serotonin interactions in the developing brain.

STUDY_SECTION_NAME: Behavioral Neuroendocrinology, Neuroimmunology, Rhythms, and Sleep Study Section [BNRS]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Cardiovascular;Cerebrovascular;Clinical Research;Emergency Care;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Heart Disease;Heart Disease - Coronary Heart Disease;Neurosciences;Rural Health;Social Determinants of Health;Stroke

ORG_CITY: BOSTON

PHR: PROJECT NARRATIVE Many patients with a heart attack or stroke do not receive high-quality care and certain patient groups (for example rural residents) are less likely to get the best care. A number of changes are taking place in the organization of the health care delivery system that may have a positive or negative impact on the delivery of heart attack and stroke care such as hospital mergers and acquisitions and hospital and emergency department openings and closures. Our goal is to understand the impact of these changes on heart attack and stroke care and whether certain patients and communities are more likely to be positively or negatively impacted.

PI_NAMEs: BEAULIEU, NANCY DEAN;ZACHRISON, KORILYN SAUSER (contact)

PROGRAM_OFFICER_NAME: KIM, THERESA YOUNGJOO

PROJECT_TERMS: access disparities;Accident and Emergency department;Action Potentials;Acute;acute care;Acute myocardial infarction;acute stroke;Address;Admission activity;Affect;Cardiac;Cardiac Catheterization Procedures;Cardiology;Cardiovascular system;Caring;Cause of Death;cerebrovascular;cerebrovascular health;Characteristics;Clinical;Communities;Community Hospitals;Compensation;Coronary Artery Bypass;Data;Databases;design;disability;Disabling;Disparity;disparity reduction;Ensure;Ethnic Origin;Event;experience;Fee-for-Service Plans;Future;gaps in access;Geographic Distribution;Goals;Health;health care delivery;health care service organization;Health Policy;Health Service Area;Health Services Accessibility;Health system;Healthcare Market;Healthcare Systems;Home;Hospital Departments;Hospital Mergers;hospital services;Hospitals;Improve Access;improved;improved outcome;innovation;Institution;Insurance;Intervention;Investments;Ischemic Stroke;marginalized population;Marketing;Mechanics;Medicaid;medical specialties;Medicare;Medicare/Medicaid;Methods;Morbidity - disease rate;mortality;Motivation;Myocardial Infarction;Neurologist;Neurology;Outcome;outcome disparities;Parents;Pathway interactions;Patient Care;Patient Transfer;Patient-Focused Outcomes;Patients;Pattern;percutaneous coronary intervention;Performance;Physicians;Policies;policy implication;post stroke;Protocols documentation;Quality of Care;Quasi-experiment;Race;Regulation;Rehabilitation therapy;Reperfusion Therapy;Resources;Risk;Rural;rural area;Rural Community;rural dwellers;Rural Health;Rural Hospitals;rural patients;safety net;sex;Site;sociodemographics;Specialist;Speed;Stroke;stroke rehabilitation;System;Technology;telestroke;tertiary care;Thrombectomy;Time;Variant

PROJECT_TITLE: The Effects of Changing Health Care Markets on Cardiovascular and Cerebrovascular Care and Outcomes

STUDY_SECTION: ODHS

STUDY_SECTION_NAME: Organization and Delivery of Health Services Study Section[ODHS]


ORG_CITY: COLUMBIA

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

ORG_STATE: SC

PHR: NARRATIVE Sepsis is a rapid-developing and life-threatening condition caused by the body’s extreme reaction to an infection. Early detection of sepsis-causing agents enables precise treatment and higher chance of survival for patients, but current molecular diagnostic technologies still depend on lengthy blood culture. This MIRA project aims to develop a blood culture-independent sensing device to accurately detect sepsis-causing pathogens in about 2 hours after blood sampling.

PI_NAMEs: LIU, CHANG  (contact)

PROGRAM_OFFICER_NAME: ZHAO, XIAOLI

PROJECT_TERMS: Affinity;Antibiotic Therapy;Antibiotics;Bacterial Infections;Biochemistry;Biological;Biological Assay;Biological Markers;Biosensing Techniques;Biosensor;Blood;Blood specimen;Cause of Death;Chemistry;Circulation;Clinical;clinical diagnosis;Clinical Treatment;cost effective;Detection;detection sensitivity;Devices;Diagnostic Procedure;diagnostic technologies;doctoral student;Early Diagnosis;Ensure;Genomics;Goals;Hospitalization;Hour;improved;in-vitro diagnostics;Infection;innovation;Life;Ligand Binding;Membrane Proteins;Mentors;Methodology;Methods;microelectronics;microorganism;microorganism growth;molecular diagnostics;mortality;Mycoses;nanoengineering;nanopore;Nanotechnology;novel;Paper;pathogen;Pathogen detection;Patients;Postdoctoral Fellow;Preparation;Procedures;Prognosis;protein biomarkers;Proteomics;prototype;Publishing;Reaction;release factor;Research;Research Project Grants;Risk;Sampling;Secure;Sepsis;septic patients;Source;Specificity;success;user-friendly;Virulence Factors;Virus Diseases

PROJECT_TITLE: Rapid Culture-Independent Detection of Sepsis Causing Microorganism Directly from Blood

STUDY_SECTION_NAME: Maximizing Investigators' Research Award - D Study Section[MRAD]