NIH_SPENDING_CATS: Biotechnology;Cancer;Immunotherapy;Orphan Drug;Precision Medicine;Rare Diseases

PI_NAMEs: MERIC-BERNSTAM, FUNDA  (contact)

PROJECT_TERMS: Acceleration;Address;Animal Model;antileukemic agent;Biological Assay;Biological Markers;Biological Response Modifier Therapy;biomarker driven;biomarker validation;Biotechnology;Blood;cancer cell;Cancer Center Support Grant;Cancer Patient;Caring;Cells;Characteristics;Clinical;Clinical Investigator;clinical practice;Clinical Trials;Collaborations;Combined Modality Therapy;Conduct Clinical Trials;design;Development;Developmental Therapeutics Program;Disease;Drug Design;drug development;drug discovery;early phase clinical trial;Eligibility Determination;Environment;Exhibits;experience;first-in-human;Functional disorder;Funding;Genomics;Goals;Grant;Growth;Human Cell Line;Immuno-Chemotherapy;immunotherapy trials;Individual;individual patient;Industry;Infrastructure;inhibitor;Institution;instrumentation;inter-institutional;interest;Investigation;investigator-initiated trial;Investments;JAK2 gene;Journals;Laboratories;Lead;Lymphoma;Malignant neoplasm of lung;Malignant neoplasm of ovary;Malignant Neoplasms;member;Modeling;Molecular;Molecular Biology;molecular subtypes;Molecular Target;Moon;mouse model;Mutation;Nature;New Agents;novel;novel therapeutics;optimal treatments;Oxidative Phosphorylation;Pathway interactions;patient population;Patient Selection;Patients;Peer Review;personalized medicine;Pharmaceutical Preparations;pharmacodynamic biomarker;Pharmacologic Substance;Phase;Physicians;PIK3CG gene;Platinum;pre-clinical;pre-clinical research;Precision therapeutics;preclinical trial;predicting response;predictive marker;predictive test;Predisposition;Primary Neoplasm;Process;Prognostic Factor;programs;Proliferating;Property;Proteins;Proto-Oncogene Protein c-kit;Publications;rare cancer;Research;Research Personnel;Resistance;Resource Sharing;response;Role;Sampling;Scientist;Signal Transduction;Site;Skp2 Proteins;Source;standard of care;STAT3 gene;targeted agent;targeted treatment;Technology;Testing;therapy development;Time;tool;Treatment Failure;tumor;Tumor Biology;tumor growth;tumorigenic;ubiquitin ligase;Validation;Work

PROJECT_TITLE: 15 Developmental Therapeutics


ADMINISTERING_IC: CA

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Digestive Diseases;Immunotherapy;Orphan Drug;Pancreatic Cancer;Radiation Oncology;Rare Diseases

ORG_CITY: HOUSTON

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PI_NAMEs: BROCK, KRISTY  (contact)

PROJECT_TERMS: Address;Affect;Anatomy;authority;Biological;Biological Markers;Biology;Blood;Cancer Center Support Grant;cancer imaging;Caring;chemoradiation;Chemotherapy and/or radiation;Clinical;Clinical Research;Collaborations;Combined Modality Therapy;Communities;crypt cell;Development;Diagnosis;Diagnostic Imaging;disease diagnosis;DNA Damage;DNA Markers;DNA Repair;DNA Repair Pathway;ds-DNA;Effectiveness;Faculty;Fasting;Funding;Goals;Heart;Hypoxia;Image;image guided radiation therapy;imaging biomarker;imaging modality;imaging platform;imaging program;Immune;immune activation;Immunomodulators;Immunotherapy;improved;innovation;International;intestinal crypt;Journals;Lung;Magnetic Resonance;Magnetic Resonance Imaging;Malignant neoplasm of lung;Malignant neoplasm of pancreas;Malignant Neoplasms;member;metabolic imaging;Mission;Modality;molecular imaging;multidisciplinary;Nature;Normal tissue morphology;novel;novel imaging technique;pancreas radiation therapy;Paper;PARP inhibition;Pathway interactions;Patients;Peer Review;Photons;Physicians;Physics;Positron-Emission Tomography;preclinical imaging;preclinical study;predicting response;predictive marker;programs;Proteins;Proton Radiation;proton therapy;Protons;Publishing;Radiation;Radiation Dose Unit;Radiation Oncology;Radiation therapy;radiomics;Recommendation;Resource Sharing;response;response biomarker;Role;Science;Scientific Advances and Accomplishments;Scientist;Site;Staging;T cell response;Techniques;Technology;Testing;Therapeutic;Therapy trial;Time;Tissues;Toxic effect;trafficking;Translating;translational study;Treatment-related toxicity;tumor;tumor microenvironment;tumorigenesis;Visualization;WNT Signaling Pathway

PROJECT_TITLE: 29 Radiation Oncology and Cancer Imaging

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


NIH_SPENDING_CATS: Behavioral and Social Science;Biomedical Imaging;Biotechnology;Cancer;Cancer Genomics;Clinical Research;Comparative Effectiveness Research;Cost Effectiveness Research;Data Science;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Human Genome;Lung;Lung Cancer;Pediatric;Pediatric Cancer;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases;Social Determinants of Health

PI_NAMEs: SCHEET, PAUL A (contact)

PROJECT_TERMS: Address;Affect;Atlases;Automobile Driving;Behavior Therapy;Behavioral;Big Data;biobehavior;Bioinformatics;Biological Assay;Biological Factors;Biological Markers;biomarker discovery;biomarker identification;Biometry;blood-based biomarker;Breast;Cancer Burden;cancer care;Cancer Center;Cancer Center Support Grant;Cancer Detection;Cancer Etiology;cancer health disparity;cancer initiation;Cancer Patient;cancer prevention;cancer risk;Cancer Survivor;Carcinogen exposure;care delivery;care outcomes;Catchment Area;chemotherapy;childhood cancer survivor;Clinical;Clinical Trials;cohort;Collaborations;comparative effectiveness;Complement;Computational Biology;Computer Analysis;Computing Methodologies;cost-effectiveness evaluation;Data Sources;Decision Making;Demography;design;Detection;Diagnosis;Diagnostic;Discipline;Disease;DNA;early detection biomarkers;Early Diagnosis;Economic Factors;Economics;effective intervention;Environmental Risk Factor;Epidemiologic Factors;Epidemiology;ethnic minority;Etiology;exome;Family;follow-up;Funding;Genetic;genetic epidemiology;genetic variant;Genets;Genome;Genomics;Germ Lines;Goals;Health;health care delivery;Health Policy;high risk;Human Genetics;improved;improved outcome;Individual;individualized prevention;innovation;insight;Institution;Investigation;Journals;Light;low dose computed tomography;low socioeconomic status;Lung;Malignant Childhood Neoplasm;Malignant neoplasm of lung;Malignant Neoplasms;Marker Discovery;Mathematics;member;metabolomics;Mexican Americans;microbiome;Modeling;modifiable behavior;Molecular;neoplasm registry;next generation sequencing;novel;novel strategies;Nucleic Acids;older adult;Oncology;Organ;Outcome;Ovary;Paper;Pathology;Pathway interactions;Patient-Focused Outcomes;Patients;Pattern;Peer Review;Phase;Policies;Policy Maker;Population;Population Database;population health;Population Sciences;preclinical study;Predisposing Factor;premalignant;Prevention program;programs;Proteins;Proteomics;Public Health;Publishing Peer Reviews;Quality of life;racial minority;Research;Research Personnel;Resource Sharing;Resources;Risk;Risk Assessment;risk prediction;RNA;Role;Sampling;screening;social;social factors;Statistical Models;successful intervention;Surveys;Survivors;survivorship;Techniques;Technology;Testing;Texas;Tissues;tool;Treatment Effectiveness;Treatment Efficacy;treatment response;tumor progression;Underinsured;Uninsured;Variant;whole genome;X-Ray Computed Tomography

PROJECT_TITLE: 27 Risk, Detection and Outcomes


NIH_SPENDING_CATS: Behavioral and Social Science;Biotechnology;Cancer;Colorectal Cancer;Digestive Diseases;Lung;Lung Cancer;Obesity;Orphan Drug;Prevention;Rare Diseases;Tobacco;Tobacco Smoke and Health

PI_NAMEs: VILAR SANCHEZ, EDUARDO  (contact)

PROJECT_TERMS: Algorithms;ARID1A gene;Basen;Behavior;behavior change;Behavior Therapy;Behavioral;Behavioral Mechanisms;Biological;Biological Markers;Biological Response Modifier Therapy;Bupropion;cancer biomarkers;Cancer Center Support Grant;cancer prevention;Cancer Prevention Intervention;Cancer Prevention Trial;cancer risk;Cancer Survivor;carcinogenesis;Chemoprevention;Clinical;clinical practice;Collaborations;Colon Carcinoma;Colorectal Cancer;Communities;community setting;Critical Pathways;depressive symptoms;Development;Diet;DNA Repair;drug repurposing;Early identification;Effectiveness;Electroencephalography;energy balance;Event;Exercise;experience;Funding;Future;Genomics;Goals;Health;Health Disparities Research;Health Promotion;high risk population;Immune;improved;Incidence;Individual;Inherited;Intervention;Journals;Knowledge;lung cancer prevention;Malignant Breast Neoplasm;Malignant neoplasm of liver;Malignant neoplasm of lung;Malignant neoplasm of ovary;Malignant Neoplasms;member;Molecular;mortality;Nature;neural;Nicotine;novel;novel therapeutic intervention;Oncogenic;Paper;Pathway interactions;Patients;Peer Review;Pharmaceutical Preparations;Pharmacotherapy;Poly(ADP-ribose) Polymerase Inhibitor;pre-clinical;Pre-Clinical Model;Precancerous Polyp;preclinical study;prevent;Prevention;prevention clinical trial;Prevention program;Prevention Research;Prevention strategy;preventive intervention;programs;psychobiologic;psychologic;Publishing;Research;Research Personnel;Resource Sharing;Rewards;Risk Behaviors;Risk Factors;Science;Smoker;smoking cessation;Smoking Cessation Intervention;social;Social Behavior;Survivors;Sushi Domain;Syndrome;Testing;Tobacco;Translating;tumorigenesis;vaccine development;varenicline;Weight maintenance regimen

PROJECT_TITLE: 28 Cancer Prevention


NIH_SPENDING_CATS: Cancer;Cervical Cancer;Clinical Research;Colorectal Cancer;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Liver Disease;Lung;Lung Cancer;Obesity;Prevention;Primary Health Care;Sexually Transmitted Infections;Women's Health Research

PI_NAMEs: HAWK, ERNEST T. (contact)

PROJECT_TERMS: Address;Area;Cancer Burden;Cancer Center Support Grant;Cancer Control;cancer prevention;cancer risk;care systems;Catchment Area;Categories;Cervical Cancer Screening;Cities;Clinical;clinical care;Clinical Preventive Practices;Collaborations;Colorectal;Colorectal Cancer;Colposcopy;Communities;community center;community engagement;Community Health Education;community organizations;Community Outreach;community partners;community partnership;Community Relations;community-centered;Country;County;Data;data sharing;Data Sources;Databases;Dedications;Development;Division of Cancer Prevention;Education;Equity;evidence base;Evidence based practice;Faculty;Faith-based organization;Federally Qualified Health Center;Goals;Health;Health Policy;Health system;Human Papilloma Virus Vaccination;Human Papillomavirus;improved;improved outcome;Incidence;Infrastructure;Institution;Intervention;Investments;Knowledge;Leadership;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Medicaid;member;Mission;Monitor;mortality;Obesity;Patient Care;patient population;Peer Review;Persons;Policies;Population;population health;Positioning Attribute;Prevention;Primary carcinoma of the liver cells;Professional Education;programs;Provider;public education;Public Policy;Research;Research Infrastructure;Research Personnel;Research Priority;Resources;Risk Factors;screening;screening services;service delivery;Services;Strategic Planning;System;Testing;Texas;Tobacco use;Training and Education;translational engagement;Translational Research;trend;Ultraviolet Rays;Uninsured;United States Preventative Services Task Force;waiver;Woman;Work

PROJECT_TITLE: Community Outreach and Engagement


NIH_SPENDING_CATS: Cancer;Clinical Research

PI_NAMEs: KANODIA, SHREYA  (contact)

PROJECT_TERMS: Applications Grants;Area;Award;Basic Science;Cancer Center Support Grant;career;Clinical;Core Facility;Development;Extramural Activities;Faculty Recruitment;faculty support;Fostering;functional genomics;Funding;Goals;Grant;Immunologic Monitoring;Individual;Institution;Interdisciplinary Study;Intervention;Investments;Measurement;member;metabolomics;Methods;microbiome;new technology;Oncology;Peer Review;Pilot Projects;programs;recruit;Research;Research Personnel;Resource Sharing;Services;shared decision making;Technology

PROJECT_TITLE: Development Funds


NIH_SPENDING_CATS: Cancer;Prevention

PI_NAMEs: DRAETTA, GIULIO FRANCESCO (contact)

PROJECT_TERMS: Advisory Committees;Aman;authority;Cancer Center;Cancer Center Support Grant;cancer health disparity;cancer prevention;career;Charge;Clinical;Clinical Research;Clinical Research Protocols;Collaborations;Communication;Communities;Community Outreach;Concept Review;Department chair;Education;Employee;empowerment;Ensure;Evaluation;experience;Faculty;Feedback;Focus Groups;Foundations;Funding;Goals;graduate student;Grant;improved;Infrastructure;Institution;Interdisciplinary Study;Knowledge;Leadership;Malignant Neoplasms;meetings;Mission;Patient Care;population based;Population Sciences;Prevention;Principal Investigator;Process;Productivity;programs;Recommendation;recruit;Research;Research Personnel;Resource Sharing;Scientist;Strategic Planning;Structure;Surveys;Texas;Translational Research;undergraduate education;undergraduate student;University of Texas M D Anderson Cancer Center;Update;Vision

PROJECT_TITLE: Leadership, Planning and Evaluation


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Patient Safety

PI_NAMEs: LITTON, JENNIFER KEATING (contact)

PROJECT_TERMS: Accountability;Aman;Businesses;Cancer Center Support Grant;Child;Clinical;Clinical Data;Clinical Management;Clinical Protocols;Clinical Research;Clinical Research Protocols;Clinical Trials;Computer Systems;Conduct Clinical Trials;Data;data management;data resource;Development;Disease;education research;Electronic Health Record;electronic health record system;Electronics;Enrollment;Ensure;Ethics;Evaluation;Future;Goals;Grant;Home;human subject;improved;industry partner;Infrastructure;Institution;Institutional Review Boards;Intervention;Lead;Legal;life span;Link;migration;Minority;Monitor;Multi-Institutional Clinical Trial;National Clinical Trials Network;Occupational activity of managing finances;Online Systems;organizational structure;Participant;Patients;Pediatric Oncology;Performance;Positioning Attribute;Process;programs;Protocols documentation;Ramp;recruit;Request for Proposals;Research;Research Infrastructure;Research Personnel;Safety;safety study;Services;Site;Structure;Support System;System;systems research;Time;Woman

PROJECT_TITLE: Clinical Protocol and Data Management


PI_NAMEs: WESTIN, SHANNON NEVILLE (contact)

PROJECT_TERMS: Accountability;Aman;Anderson syndrome;behavioral health;Budgets;Cancer Center;Cancer Center Support Grant;Clinical;Clinical Protocols;Clinical Research;Clinical Research Protocols;Clinical Trials;Computerized Medical Record;Contracts;Department chair;Development;Discipline;Disease;Electronics;Eligibility Determination;Enrollment;Ensure;Evaluation;Faculty;follow-up;Goals;Grant;Health Services Research;Human Subject Research;improved;Informed Consent;Institution;Institutional Review Boards;Interdisciplinary Study;Intervention;Intervention Trial;Leadership;Localized Disease;Medical;meetings;member;Monitor;organizational structure;Outcome;Patients;Peer Review;Performance;Positioning Attribute;Process;Program Efficiency;programs;Protocols documentation;psychosocial;Recommendation;Report (document);Reporting;Research;Review Committee;Site;Source;Surveys;System;Therapeutic;Therapeutic Studies;timeline;treatment planning;web-based tool

PROJECT_TITLE: Protocol Review and Monitoring System


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: UNIVERSITY PARK

ORG_DEPT: PSYCHOLOGY

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

ORG_STATE: PA

PHR: PROJECT NARRATIVE Socioeconomic disparities in physical and mental health problems are large, persistent, and severe and stem in part from adaptations to biological, cognitive, affective and behavioral systems necessitated by chronically stressful developmental contexts. Interventions attending to these adaptations and taking the context of a child’s development seriously are needed to address the ever-growing health disparities affecting low-income youth. The proposed study promises to further NIMH’s Strategic Framework on Youth Mental Health Disparities by improving our understanding of culturally affirming interventions with potential to treat internalizing syndromes and disorders, protect against biological embedding of chronic stress, and reduce mental health disparities.

PI_NAMEs: WADSWORTH, MARTHA E (contact)

PROGRAM_OFFICER_NAME: ROONEY, MARY

PROJECT_TERMS: Address;Adolescent;adolescent mental health;Affect;Affective;alpha-amylase;Anxiety;anxiety symptoms;Behavior;Behavioral;Biological;biological adaptation to stress;Biological Markers;Calibration;Child Development;Chronic;Chronic stress;Clinic;Clinical;Cognitive;Community Actions;Community Healthcare;comparison control;confirmatory trial;Control Groups;coping;Coping Skills;COVID-19;COVID-19 pandemic;data integration;depressive symptoms;design;Development;Disease;Disparity;Early Intervention;Educational process of instructing;Emergency Situation;empowerment;Enrollment;Ethnic Origin;Ethnic Population;experience;Exposure to;Family;Fostering;Future;Gender;Geographic Locations;Goals;healing;health disparity;high risk;Hydrocortisone;Hyperactivity;improved;in vivo;Individual;Inequality;Informal Social Control;innovation;Intervention;Justice;Left;Location;Logic;Low income;marginalization;Mediating;Mediator;member;Mental Depression;Mental disorders;Mental Health;Mental Health Services;Methods;Modeling;National Institute of Mental Health;Needles;non-suicidal self injury;Outcome;pandemic disease;pandemic impact;pediatric trauma;peer;Pennsylvania;physical conditioning;Physiological;Physiology;Poverty;primary outcome;programs;Race;racial minority population;racial population;Randomized;repaired;Resources;Risk;Risk Marker;rural area;Services;Site;skill acquisition;skills;social;social culture;social group;Social Identification;Social isolation;socioeconomic disparity;socioeconomics;stem;Stress;Stress and Coping;stress management;stress reactivity;stress symptom;stressor;substance misuse;suicidal;suicidal behavior;suicidal risk;Surgeon;Symptoms;Syndrome;System;Teenagers;Testing;theories;therapy design;Time;tool;Trauma;traumatic stress;treatment effect;trend;trial enrollment;urban area;Waiting Lists;Work;Youth

PROJECT_TITLE: Confirmatory Efficacy of the Building a Strong Identity and Coping Skills Program for Low-Income Young Adolescents

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-N (04)]


ADMINISTERING_IC: TR

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Caregiving Research;Childhood Injury;Clinical Research;Emergency Care;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Patient Safety;Pediatric;Physical Injury - Accidents and Adverse Effects;Unintentional Childhood Injury

ORG_CITY: AMHERST

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

ORG_STATE: NY

PHR: The proposed research is relevant to public health because it will engage family caregivers to identify factors underlying preventable hospital complications in injured children and youth with special health care needs (CYSHCN). The study’s results will inform interventions to improve emergency care quality and reduce hospital complications in this population. The proposed research is therefore relevant to the NIH’s mission because interventions will enhance the health of injured CYSHCN.

PI_NAMEs: LILLVIS, DENISE FINLEY (contact)

PROGRAM_OFFICER_NAME: BROWN, PATRICK

PROJECT_TERMS: Academy;Address;adolescent health;adverse outcome;Affect;American;Asthma;autism spectrum disorder;Award;Behavioral;care delivery;care providers;caregiver strain;Caring;Child;Child Care;Child Health;Child health care;Childhood Injury;Chronic;Complement;Complex;Data;Demographic Factors;Development;Discrimination;Disparity;disparity elimination;Down's Syndrome;Education;Elements;Emergency Care;Emergency Situation;Emotional;Ensure;experience;Face;Family;Family Caregiver;Family Demographies;Funding;Future;Goals;Guidelines;Health;health care delivery;health care disparity;health disparity;Healthcare;Heart Arrest;hospital care;Hospital complications;Hospital Costs;Hospitals;improved;Injury;innovation;interest;Intervention;Interview;Knowledge;Length of Stay;Letters;Maternal and Child Health;Measurement;Medical;Mental Depression;Mission;Modality;Operating Rooms;Outcome;Parents;pediatric trauma;Pediatrics;Population;Positioning Attribute;Pre-hospitalization care;Provider;Public Health;Quality of Care;Questionnaires;recruit;Reporting;Research;Research Personnel;resilience;Risk;Sampling;Science;Spinal Dysraphism;Structure;Surveys;System;tertiary care;Testing;translational scientist;Trauma;trauma care;United States National Institutes of Health;Vision;Voice;Work;Youth

PROJECT_TITLE: Experiences of Parents Seeking Emergency Care for Injured Children with Special Health Care Needs

STUDY_SECTION_NAME: Special Emphasis Panel[ZTR1 CI-4 (01)]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Mental Health;Mental Illness;Neurosciences;Pediatric;Prevention;Psychosis;Rehabilitation;Serious Mental Illness

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: Project Narrative The proposed research is a randomized controlled trial which will test whether a brief group-based behavioral intervention, called Resilience Training (RT), leads to sustained reductions in subclinical psychotic symptoms (“psychotic experiences”) and other transdiagnostic symptoms of psychopathology, and linked changes in emotion reactivity, hippocampal connectivity and hippocampal responses, when compared to a psychoeducational control condition. The study will also assess whether RT positively impacts objective functional outcomes and the onset of psychiatric disorders over time and whether the hypothesized linked psychological (emotion reactivity) and neural (hippocampal connectivity and responses) mechanisms of RT mediate its effects on these functional and clinical outcomes. If the predictions of this project are confirmed, follow-up work can begin to implement RT within college campuses and other communities of young adults, providing one evidence-based, transdiagnostic tool for addressing the worsening mental health crisis in this population.

PI_NAMEs: HOLT, DAPHNE J (contact)

PROJECT_TERMS: Address;Affect;Age;American;Anxiety;Anxiety Disorders;arm;Behavior Therapy;Brain;Brain region;Chronic;Clinical;college;Communities;community setting;conditioned fear;Control Groups;Controlled Clinical Trials;Deterioration;Development;Diagnostic;diagnostic tool;disability;disability burden;Distress;Emotional;Emotions;Employee;Enrollment;Epidemiology;evidence base;experience;Family;Feeling;Financial Hardship;follow-up;Foundations;functional disability;Functional disorder;Functional impairment;functional outcomes;Genetic;Goals;Hearing;High Prevalence;Hippocampus;Impairment;improved;Incidence;Individual;Intervention;life span;Link;Measures;Mediating;Medical;Mental Depression;Mental disorders;Mental Health;mindfulness;Modeling;Mood Disorders;Moods;Names;neural;neuroimaging;novel;Outcome;Participant;Pathway interactions;Pattern;Persons;Population;post intervention;precision medicine;prevent;Prevention;Prevention approach;Preventive;preventive intervention;primary care clinic;Psychiatric Diagnosis;psychiatric symptom;psychoeducation;psychologic;Psychopathology;Psychoses;psychotic;psychotic symptoms;Randomized;randomized, clinical trials;Randomized, Controlled Trials;Recurrence;Research;resilience;response;retention rate;Risk;Risk Marker;Sample Size;Sampling;Schools;Services;Stress;Substance Use Disorder;suicidal;suicidal behavior;Symptoms;Testing;Time;Training;Training Programs;university student;Vocation;Waiting Lists;Work;Workplace;young adult

PROJECT_TITLE: A randomized controlled trial of a preventive behavioral intervention for young adults with psychotic experiences


ADMINISTERING_IC: EB

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Autoimmune Disease;Bioengineering;Biotechnology;Brain Disorders;Multiple Sclerosis;Neurodegenerative;Neurosciences;Regenerative Medicine

ORG_CITY: ANN ARBOR

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PI_NAMEs: MORRIS, AARON HARVEY (contact)

PROGRAM_OFFICER_NAME: FEHR, TUBA HALISE

PROJECT_TERMS: Adaptive Immune System;Advisory Committees;antigen binding;Antigens;Autoimmune;Autoimmune Diseases;Autoimmunity;Award;Binding;Biocompatible Materials;Biological Markers;Biopsy;Biosensor;career;Clinical Management;Computer Analysis;Demyelinations;design;Detection;Development;Diagnostic;Disease;Disease Progression;Disease remission;Engineering;Euthanasia;experience;Fluorescence Resonance Energy Transfer;fluorophore;Gene Chips;Gene Expression;Harvest;Hydrogels;Immune;Immune response;immunoengineering;Immunologics;Immunology;Implant;implant material;in vivo;Label;Location;Machine Learning;Monitor;Multiple Sclerosis;Mus;Natural Immunity;non-invasive monitor;novel diagnostics;optical sensor;Peptides;Pharmaceutical Preparations;Physiological;Population;prevent;prognostic;Relapse;Research Personnel;scaffold;sensor;single-cell RNA sequencing;Techniques;Testing;Time;Tissue Engineering;tool;Training;Validation;Work

PROJECT_TITLE: Immulogical Niches and Non-invasive Biosensors for Autoimmune Monitoring

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: PROJECT NARRATIVE Nephrolithiasis is a common and painful condition with considerable morbidity the incidence of which is increasing among youth. The evidence base supporting management of common scenarios is weak due in part to the few urologists engaged in research. In this project, we leverage existing data and research infrastructure to accelerate the research careers of early-stage investigators and generate important knowledge of the course of non-obstructive kidney stones and the experiences after surgery to remove kidney and/or ureteral stones among pediatric patients.

PI_NAMEs: TASIAN, GREGORY EDWARD (contact)

PROGRAM_OFFICER_NAME: NIHALANI, DEEPAK

PROJECT_TERMS: Acceleration;Address;associated symptom;Benign;career;Caregivers;Caring;Chicago;Child;Childhood;clinical investigation;Collaborations;Communities;cost;Data;data access;data infrastructure;data resource;design;Disease;Ensure;Environment;Event;evidence base;experience;Funding;Future;Generations;Goals;Health system;Hydration status;improved;improved outcome;Incidence;Individual;Infrastructure;innovation;Interdisciplinary Study;Kidney;Kidney Calculi;kidney surgery;Knowledge;Learning;member;Methodology;Mission;Morbidity - disease rate;National Institute of Diabetes and Digestive and Kidney Diseases;Nephrolithiasis;Operative Surgical Procedures;Outcome;Pain;patient oriented;Patient Outcomes Assessments;Patients;Pediatric Hospitals;pediatric patients;Philadelphia;predictive modeling;prevent;Prevention;programs;Recurrence;Research;Research Infrastructure;Research Personnel;Research Priority;Research Project Grants;research study;Research Support;Resources;Scientific Advances and Accomplishments;Stents;Strategic vision;success;trial design;United States National Institutes of Health;Ureteroscopy;Urinary Calculi;urologic;Urologic Diseases;Urologist;Urology;Wisconsin;Youth

PROJECT_TITLE: Personalizing Outcomes of Nephrolithiasis in Youth (PONY)

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-M (M2)]


PROJECT_TERMS: Acceleration;Address;associated symptom;base;Benign;career;Caring;Chicago;Child;Childhood;Clinical;clinical care;clinical investigation;Collaborations;Communities;community collaboration;comparative effectiveness study;Data;data access;Disease;Ensure;Environment;evidence base;Funding;Future;Generations;Goals;Health;Health system;improved;improved outcome;Infrastructure;Institution;interdisciplinary collaboration;Kidney Calculi;Knowledge;Leadership;Learning;meetings;Mission;National Institute of Diabetes and Digestive and Kidney Diseases;Nephrolithiasis;North America;Operative Surgical Procedures;organizational structure;Outcome;patient engagement;Patient-Focused Outcomes;Patients;Pediatric Hospitals;personalized management;Philadelphia;prevent;Prevention;programs;prospective;Randomized, Controlled Trials;Research;Research Personnel;Research Priority;Research Project Grants;Research Support;Resources;skills;Stents;success;sustainable resource;Talents;Urinary Calculi;urologic;Urologic Diseases;Urology;Wisconsin;Youth

PROJECT_TITLE: Personalizing Outcomes of Nephrolithiasis in Youth (PONY) Administrative Core


NIH_SPENDING_CATS: Chronic Pain;Clinical Research;Comparative Effectiveness Research;Health Services;Kidney Disease;Pain Research;Patient Safety;Pediatric;Prevention;Urologic Diseases

PI_NAMEs: CHU, DAVID  (contact)

PROJECT_TERMS: 21 year old;acute care;adaptive intervention;Admission activity;Adult;Affect;Anxiety;associated symptom;Benefits and Risks;career;Caregivers;Caring;Characteristics;Chicago;Child;Childhood;Chronic Disease;Clinical;Collaborations;comorbidity;comparative effectiveness trial;Data;Data Analyses;data modeling;Disease;effectiveness/implementation trial;Epidemiological trend;Equilibrium;Event;evidence base;experience;follow-up;Future;Goals;Guidelines;health care service utilization;high risk;Hydration status;improved;improved outcome;Incidence;Individual;Infrastructure;Inpatients;Kidney Calculi;Knowledge;Link;Measures;Mission;model development;Modeling;National Institute of Diabetes and Digestive and Kidney Diseases;Natural History;Nephrolithiasis;Operative Surgical Procedures;Outcome;Pain;Pain intensity;Pain interference;Participant;patient oriented;Patient Outcomes Assessments;Patient-Centered Care;Patients;Pediatric Hospitals;personalized management;Persons;Phenotype;Philadelphia;Population;Postoperative Pain;Postoperative Period;postoperative recovery;Pragmatic clinical trial;pragmatic trial;predictive modeling;predictive tools;Prevention;programs;prospective;Prospective Studies;Recurrence;Recurrent disease;Reporting;Research;Research Personnel;Research Project Grants;Research Project Summaries;Residual state;Resources;risk prediction model;risk stratification;secondary analysis;Source;Stents;Subgroup;Symptoms;treatment as usual;trend;trial comparing;trial enrollment;United States;Ureteroscopic operation;Ureteroscopy;urinary;Urinary Calculi;urologic;Urologist;Visit;Wisconsin;Youth

PROJECT_TITLE: Personalizing Outcomes of Nephrolithiasis in Youth (PONY) Research Project


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Neurosciences;Substance Misuse

ORG_CITY: CINCINNATI

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF CINCINNATI

ORG_STATE: OH

PHR: Project Narrative The proposed project will advance our understanding of how changes in brain cell function relate to malfunctioning decision-making in alcohol use disorder. The results of this research will guide future studies that seek to develop new treatments for people with or at risk of developing alcohol use disorder.

PI_NAMEs: TIMME, NICHOLAS M (contact)

PROGRAM_OFFICER_NAME: CUI, CHANGHAI

PROJECT_TERMS: Acclimatization;Address;Affect;alcohol abuse therapy;Alcohol consumption;alcohol effect;alcohol exposure;alcohol research;alcohol reward;alcohol risk;alcohol use disorder;Alcohols;Animals;Anterior;Applications Grants;Area;Aversive Stimulus;Award;Behavior;Behavioral;Blood;Brain;brain cell;Brain region;career;career development;Cell Physiology;Cells;Collaborations;computational neuroscience;Cues;Data;Data Set;Decision Making;density;Disease;drinking;Educational workshop;Electrophysiology (science);Environment;Ethanol;Exhibits;experimental study;Faculty;flexibility;Foundations;Fright;Future;Goals;Head;Impairment;improved;Individual;insight;International;Intervention;Journals;Laboratories;Medial;Mentors;Modification;Mus;neural;neural circuit;neural correlate;Neurobiology;Neurons;neurophysiology;neurotransmission;novel;Pathology;Pattern;Performance;Persons;pharmacologic;Phase;Population;Positioning Attribute;Prefrontal Cortex;Preparation;Process;Protocols documentation;Publishing;Quinine;reinforcer;repaired;Research;Research Personnel;Resistance;Resolution;Resources;Rewards;Risk;Route;sex as a biological variable;Signal Transduction;symposium;Synapses;System;Task Performances;Techniques;Testing;theories;Time;tool;Training;Ventral Striatum;visual discrimination;Water;Work

PROJECT_TITLE: Identifying how alcohol-evoked changes in neural firing affect systems level computations during decision-making


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

ORG_CITY: GAINESVILLE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Project Narrative/Public Health Relevance Adoptive cell transfer T cell immunotherapy has immense potential for treatment in several diseases, including cancer. Non-invasive quantitative imaging would be a powerful tool for evaluation of the impact of T cell modifi- cations and delivery routes, monitoring of off-target T cell accumulation, and stratification of groups of responders or non-responders to therapy on the basis of measures of T cell tumor accumulation. This project will pioneer non-invasive and quantitative tracking of adoptive T cell cancer immunotherapy using a new molecular imaging modality called magnetic particle imaging.

PI_NAMEs: RINALDI-RAMOS, CARLOS M (contact)

PROGRAM_OFFICER_NAME: ATANASIJEVIC, TATJANA

PROJECT_TERMS: Adoptive Cell Transfers;Affect;Animals;Anisotropy;Benchmarking;Biodistribution;Biological Assay;biomaterial development;Biomedical Engineering;Blood Circulation Time;cancer cell;cancer immunotherapy;Cancer Model;cancer therapy;Cell Count;Cell Survival;Cell Therapy;Cells;Charge;clinical translation;Coculture Techniques;Computer Models;Coupled;cytotoxic;Cytotoxic T-Lymphocytes;Defect;Diameter;Disease;Dose;Electron Microscopy;Elements;Environment;Euthanasia;Exocytosis;Failure;Flow Cytometry;Fluorescence Microscopy;Foundations;Future;Generations;Glioblastoma;Glioma;Goals;Image;imaging approach;imaging modality;Imaging technology;immune imaging;Immunotherapy;Impact evaluation;improved;In Vitro;in vivo;insight;instrumentation;interest;Intracranial Neoplasms;Ionizing radiation;iron oxide nanoparticle;Label;Life;Longitudinal Studies;magnetic field;Magnetic nanoparticles;Magnetic Resonance Imaging;Magnetism;Malignant Neoplasms;Measures;Mediating;Melanoma;Methods;Modeling;Modification;Molecular;molecular imaging;Monitor;Motivation;mouse model;Multimodal Imaging;Mus;nanoparticle;neoplastic cell;nuclear imaging;Organ;Oxygen;particle;Penetration;Performance;Phenotype;Physics;Polymers;preclinical evaluation;Preclinical Testing;Property;public health relevance;Qualifying;Quantitative Evaluations;quantitative imaging;Research;research and development;Research Project Grants;Resolution;responders and non-responders;response;Route;Signal Transduction;Site;Solid;Solid Neoplasm;Specificity;Stratification;success;superparamagnetism;Surface;T cell therapy;T-Lymphocyte;Therapeutic;Tissues;tomography;tool;Toxic effect;Tracer;trafficking;treatment response;tumor;uptake;Validation;Work

PROJECT_TITLE: Nanoparticles to Track T Cell Immunotherapy Using Magnetic Particle Imaging

STUDY_SECTION: IPCA

STUDY_SECTION_NAME: Imaging Probes and Contrast Agents Study Section[IPCA]


ADMINISTERING_IC: AG

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Patient Safety;Social Determinants of Health

PHR: Project Narrative This proposal will lead to the development and preliminary testing of a novel intervention, Geriatric Assessment Strategy for Ostomy Management and Adaptation (GA-STOMA), aimed at addressing unmet needs of older adults facing fecal ostomy surgery. Surgical teams are not trained to address the biopsychosocial needs of the rising number of older adults undergoing fecal ostomy surgery. The proposed intervention includes geriatric assessment and management steps to improve integration of geriatric principles into surgical care of older adults undergoing fecal ostomy surgery and will provide the training necessary to launch my career as an independent surgeon-scientist and national leader at the intersection of geriatrics and colorectal surgery.

PI_NAMEs: CAULEY, CHRISTY ELAINE (contact)

PROGRAM_OFFICER_NAME: BAKOS, ALEXIS DIANE

PROJECT_TERMS: abdominal wall;acceptability and feasibility;Address;Adherence;Affect;age-related disease;aging related;Ambulatory Surgical Procedures;Area;arm;Attitude;Benchmarking;biopsychosocial;career;career development;Caring;Characteristics;Clinic;Clinical;clinical care;Clinical Trials;clinically relevant;Cognition;Cognitive;cognitive interview;Colorectal;Colorectal Cancer;Colorectal Surgery;Complex;Data;data integration;Dehydration;Development;disability;Disease;Diverticulitis;effective intervention;Effectiveness;effectiveness trial;efficacy trial;Elderly;Ensure;Environment;Evaluation;experience;feasibility trial;Fecal Incontinence;Focus Groups;Foundations;functional independence;General Hospitals;Geriatric Assessment;Geriatrics;Goals;Guidelines;Health;Hybrids;Hydration status;improved;innovation;Institution;Intervention;intervention refinement;Intervention Trial;Interview;Intestinal Obstruction;Intestines;Lead;Leadership;leadership development;Life;Massachusetts;Medial;Medical;medical schools;meetings;member;Mentors;Mentorship;Methodology;Methods;Modeling;novel;Nurses;Nutritionist;older adult;Oncology;Operative Surgical Procedures;Ostomy;Outcome;Palliative Care;Participant;patient population;Patient-Focused Outcomes;Patients;Pelvic floor dysfunction;Pelvic Infection;Perioperative;Perioperative Nursing;Personal Satisfaction;Persons;Physical Function;physical therapist;Physicians;Play;Positioning Attribute;Preparation;prevent;Protocols documentation;Psychosocial Assessment and Care;Publications;Quality of life;randomized, clinical trials;recruit;Reporting;Research;Research Design;Research Methodology;Research Personnel;Research Project Grants;Research Training;Risk Factors;Role;Running;Scientist;skills;Social Workers;Structure;Surgeon;Surgical complication;Surgical Wound Infection;Symptoms;Testing;therapy design;therapy development;Time;Training;Training Programs;Training Support;treatment planning;trial design;United States;United States National Institutes of Health;usability;wound

PROJECT_TITLE: Improving Biopsychosocial Outcomes of Older Adults Facing Fecal Ostomy Surgery

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-6 (M1)]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Heart Disease;Lung;Pulmonary Hypertension;Rare Diseases

ORG_CITY: SEATTLE

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project narrative We propose a randomized controlled trial of valsartan in patients with pulmonary arterial hypertension and right heart failure. There are no current medications that change the natural history of right heart failure. There is ample evidence to suggest angiotensin receptor blockers may impact right heart failure, and - if confirmed by randomized evaluation - this would address a clear unmet need in heart failure management.

PI_NAMEs: LEARY, PETER J (contact)

PROGRAM_OFFICER_NAME: XIAO, LEI

PROJECT_TERMS: Activities of Daily Living;Address;Adult;Angiotensin II;Angiotensin II Receptor;Angiotensin Receptor;Angiotensin-Converting Enzyme Inhibitors;Angiotensins;Animals;Apoptosis;Area;Biochemical Markers;Cardiac;Cardiac Myocytes;Caring;Clinical;clinical efficacy;cohort;coronary fibrosis;cost;Development;Diameter;Diastole;Disease;Diuretics;Dose;effective therapy;efficacy evaluation;Etiology;Evaluation;exercise capacity;Failure;Fibrosis;Frequencies;Goals;health related quality of life;Heart;Heart failure;improved;Individual;innovation;instrument;Interstitial Lung Diseases;Left;Lung;Measures;Morbidity - disease rate;mortality;Muscle Cells;Natural History;New York;novel;novel strategies;Outcome;Participant;Pathogenesis;Pathway interactions;Patient Outcomes Assessments;Patients;Pharmaceutical Preparations;Phase;Placebos;primary endpoint;pro-brain natriuretic peptide (1-76);Progressive Disease;pulmonary arterial hypertension;Pulmonary Emphysema;Pulmonary Hypertension;pulmonary vascular remodeling;Pulmonary Vascular Resistance;Randomized;randomized placebo controlled trial;Randomized, Controlled Trials;receptor;right ventricular failure;Right Ventricular Function;Role;routine therapy;Safety;secondary endpoint;Signal Transduction;Societies;Stress;success;targeted treatment;Testing;therapeutic target;tool;United States National Institutes of Health;valsartan;Vasodilator Agents;Ventricular;Veterans;Walking;Work

PROJECT_TITLE: REVAMP-PH: REpurposing Valsartan May Protect against Pulmonary Hypertension

STUDY_SECTION: SSPT

STUDY_SECTION_NAME: NHLBI Single-Site and Pilot Clinical Trials Study Section[SSPT(JA)]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_DEPT: PHYSIOLOGY

PHR: Project Narrative Retinal degenerative diseases frequently cause failures in adaptation to changes in the statistics of visual input such as changes in the mean light level. The work proposed here aims to understand how visual adaptation operates under naturalistic stimulus conditions. This is likely to provide new insights into the diagnosis and treatment of disorders of the visual system and retinal degenerative diseases.

PI_NAMEs: FIELD, GREGORY DARIN;RIEKE, FREDERICK M (contact);ZYLBERBERG, JOEL

PROGRAM_OFFICER_NAME: WRIGHT, CHARLES BAKER

PROJECT_TITLE: Dynamic retinal coding in natural environments

STUDY_SECTION: BDE

STUDY_SECTION_NAME: Biology and Development of the Eye Study Section[BDE]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Burden of Illness;Caregiving Research;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Palliative Care;Social Determinants of Health

ORG_NAME: FRED HUTCHINSON CANCER CENTER

PHR: PROJECT NARRATIVE Financial hardship is common in people with Alzheimer's disease and dementia and their families but brief, valid and reliable measures to screen for financial hardship are not available. Current measures of financial hardship are too general or specific to other medical conditions. This project will create a group of ten patient- reported and caregiver-reported measures using item response theory that will be able to screen for patient and caregiver financial hardship in Alzheimer's disease and dementia.

PI_NAMEs: JONES, SALENE M. W. (contact)

PROGRAM_OFFICER_NAME: NOVAK, PRISCILLA JOY

PROJECT_TERMS: 3-Dimensional;Address;Affect;Algorithms;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Buffers;care costs;Caregiver Burden;Caregivers;caregiving;Caring;Child;Chronic;Clinic;Clinical;Communities;comorbidity;computerized;coping;cost;Dementia;Development;Dimensions;disability;Disease;Disparity;Elderly;Ensure;ethnic minority population;Ethnic Origin;Ethnic Population;experience;Face;Family;Feedback;Financial Hardship;Financial Support;health equity;Health Status;Home;Home Nursing Care;improved;Income;Insurance Coverage;Interview;Labor Forces;Length;life span;Long-Term Care;marginalization;marginalized population;Measurement;Measures;Mediation;Medical;Methods;Modeling;Occupational activity of managing finances;Onset of illness;Outcome;Patient Outcomes Assessments;patient screening;Patients;Persons;Population;Prevalence;Primary Care;primary caregiver;Productivity;Psychometrics;Race;racial minority population;racial population;recruit;Reporting;Resources;response;Sampling;screening;Severities;social;Social Network;Spouses;Structure;Surveys;Testing;theories;Time;Work

PROJECT_TITLE: Development of Measures to Screen for Financial Hardship in Alzheimer's Disease and Dementia

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-5 (M1)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Breast Cancer;Cancer;Clinical Research;Palliative Care;Women's Health Research

ORG_CITY: STORRS-MANSFIELD

ORG_NAME: UNIVERSITY OF CONNECTICUT STORRS

ORG_STATE: CT

PHR: 8. PROJECT NARRATIVE Identifying specific forms and features of talk that may help or hinder partners as they navigate intimacy in the context of metastatic breast cancer (MBC) is a pivotal first step in understanding if and how communication can benefit individual and relational well-being within the understudied population of metastatic breast cancer patients (MBCPs). Using a communication-based approach, this project will provide preliminary data regarding the relationships between communication and sexual, relational, and individual well-being for MCBPs, and determine the feasibility of collecting data from partners of individuals with MBC. The findings of the pilot study will address the dearth of research on communication about sexuality among MCBPs and identify forms and features of communication that patients find beneficial when navigating sexuality and intimacy in their relationship.

PI_NAMEs: DENES, AMANDA  (contact)

PROGRAM_OFFICER_NAME: EVERSON, NICOLE MARIE

PROJECT_TERMS: Address;advanced breast cancer;advanced disease;Advanced Malignant Neoplasm;Adverse effects;Aftercare;anti-cancer research;Body Image;Breast Cancer Patient;Breast Cancer Treatment;cancer diagnosis;Cancer Patient;Caring;Communication;Communications Media;Computer software;Couples;Data;Diagnosis;Disease;Disseminated Malignant Neoplasm;Distress;emotional experience;Emotions;end of life care;expectation;experience;Feeling;Fostering;Goals;Health Professional;improved;Individual;individual patient;insight;Intervention;intimate behavior;Investments;Language;Life;Link;Malignant Breast Neoplasm;Malignant Neoplasms;Measures;Mediation;Mental Health;Metastatic breast cancer;Modeling;Neoplasm Metastasis;Organ;Outcome;Participant;Partner Communications;Patients;Pattern;Personal Communication;Personal Satisfaction;physical conditioning;Pilot Projects;Population;Process;psychosocial outcome;Quality of life;Reporting;reproductive;Research;response;Role;satisfaction;sex;Sex Functioning;sexual relationship;Sexuality;Surveys;Time;treatment effect;Work

PROJECT_TITLE: Couples' Communication about Sexuality when Facing Metastatic Breast Cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-2 (M2)]


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Services;Mental Health;Mental Illness;Post-Traumatic Stress Disorder (PTSD);Substance Misuse

ORG_CITY: PISCATAWAY

ORG_NAME: RUTGERS, THE STATE UNIV OF N.J.

ORG_STATE: NJ

PHR: Project Narrative Among patients with posttraumatic stress disorders and substance use disorders (PTSD/SUD), reductions in PTSD symptom severity are associated with less subsequent substance use. The goal of this pragmatic Hybrid Type I randomized clinical trial is to compare treatment as usual with prolonged exposure, a gold standard PTSD therapy, delivered in a massed format (i.e., multiple sessions per week where patients complete PE in 2- 4 weeks instead of 3-5 months) to treatment as usual for patients with PTSD/SUD in intensive outpatient treatment at Gateway Community Services, Inc., a nationally recognized SUD treatment program. The successful completion of this project can help change the practices that drive treatment for patients with SUD/PTSD, yielding a high public health impact for a challenging comorbidity.

PI_NAMEs: HIEN, DENISE AIMEE (contact);NORMAN, SONYA

PROGRAM_OFFICER_NAME: RUDORFER, MATTHEW V

PROJECT_TERMS: Abstinence;Aftercare;Ambulatory Care;Belief;Caring;Clinical;Clinical Trials;Cognition;Communities;Community Services;comorbidity;compare effectiveness;Coping Skills;craving;depressive symptoms;Disease;Dropout;Drops;effective therapy;Effectiveness;effectiveness/implementation trial;efficacious treatment;experience;Exposure to;Feeling suicidal;Female;follow-up;Gender;Goals;Hybrids;implementation barriers;improved;Length;male;Mediator;Methods;novel;Outcome;Outpatients;Participant;Patient-Focused Outcomes;Patients;Population;Post-Traumatic Stress Disorders;process evaluation;programs;Provider;Psychotherapy;Public Health;Quality of life;randomized, clinical trials;reduce symptoms;reduced substance use;Relapse;Research;satisfaction;Severities;skills;Structure;substance use;Substance Use Disorder;Symptoms;Trauma;treatment arm;treatment as usual;treatment comparison;treatment program;Work

PROJECT_TITLE: Hybrid Effectiveness-Implementation Trial of Massed PTSD Treatment in a Community Substance Use Program

STUDY_SECTION: EMHI

STUDY_SECTION_NAME: Effectiveness of Mental Health Interventions Study Section[EMHI]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Autoimmune Disease

PHR: PROJECT NARRATIVE  Autoantibodies initiate inflammation and tissue injury in patients with autoimmune disease. This proposal will define how the ubiquitin ligase Itch regulates metabolic pathways in B cells that distinguish selection of foreign-antigen specific as compared to autoreactive B cell responses. Information from completion of these studies is the essential first step in designing therapies that could specifically inhibit autoantibodies in patients with autoimmune disease without affecting B cell responses to foreign antigens.

PI_NAMEs: MOSER, EMILY K. (contact)

PROGRAM_OFFICER_NAME: RICE, JEFFREY S

PROJECT_TERMS: Affect;Antibodies;Antibody Response;Antibody Specificity;Antigens;Apoptosis;Apoptosis Regulation Gene;Apoptotic;Autoantibodies;Autoantigens;Autoimmune;Autoimmune Diseases;autoreactive B cell;autoreactivity;B Cell Proliferation;B-Cell Acute Lymphoblastic Leukemia;B-Lymphocytes;Binding;Cell Death Induction;Cell Survival;Cells;Clone Cells;Complex;Cues;Data;Development;DNA;ds-DNA;Exposure to;extracellular;FRAP1 gene;Immunoprecipitation;Immunosuppression;In Vitro;in vivo;Inflammation;Kidney Diseases;Ligands;loss of function mutation;Mass Spectrum Analysis;Metabolic;Metabolic Pathway;Mitochondria;Modeling;Molecular;mouse model;Mus;Oxidative Phosphorylation;Oxygen Consumption;pathogenic autoantibodies;Patients;Peripheral;Plasma Cells;Predisposition;preservation;prevent;Production;Proliferating;Proteins;Pruritus;rational design;Reporting;Resistance;response;Role;Substrate Interaction;systemic autoimmune disease;Systemic Lupus Erythematosus;targeted treatment;therapy design;tissue injury;TNFSF5 gene;ubiquitin ligase;ubiquitin-protein ligase;Work

PROJECT_TITLE: Metabolic enforcement of selection in anti-DNA B cells vs. antigen-specific B cells

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IIDB-S (02)]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding

ORG_CITY: GRANVILLE

ORG_DEPT: CHEMISTRY

ORG_NAME: DENISON UNIVERSITY

PHR: PROJECT NARRATIVE Many pathogenic and symbiotic bacteria require the metal manganese to survive in eukaryotic hosts, like mammals and plants. This project will determine the mechanism of action of a small protein of only 42 amino acids in manganese homeostasis in the model bacterium Escherichia coli. As small proteins are a newly-recognized class of proteins with unique features that could be exploited as biotechnology reagents, this study will not only increase understanding of bacterial survival and growth in stressful environments, but will provide insight into a poorly- understood type of gene to expand fundamental knowledge of how cells work.

PI_NAMEs: WATERS, LAUREN  (contact)

PROGRAM_OFFICER_NAME: RIGAS, MARC

PROJECT_TERMS: Address;Affect;Amino Acids;Award;Bacteria;Bacteria sigma factor KatF protein;Binding;Binding Proteins;Biological Assay;Biotechnology;C-terminal;Cell Fractionation;Cell Physiology;Cells;chemical reaction;Coenzymes;Cytoprotection;design;Disease;Drug Metabolic Detoxication;Enterobacteriaceae;Environment;Enzymes;Escherichia coli;experimental study;Genes;Genetic Screening;Goals;Gram-Negative Bacteria;Growth;Half-Life;Homeostasis;Human;hybrid protein;In Vitro;insight;Knowledge;Length;Mammals;Manganese;Mediating;Medical;member;Membrane;Metals;Methods;Modeling;Molecular;Monitor;mutant;Mutation;novel;Organism;Outcome;Oxidative Stress;pathogenic bacteria;Pathogenicity;Peptide Fragments;Peptide Hydrolases;Peptide Signal Sequences;periplasm;Phenotype;Physiology;Plants;Population;Post-Translational Regulation;Process;Property;Protein Biochemistry;protein degradation;protein protein interaction;Proteins;Proteolysis;proteostasis;Reactive Oxygen Species;Reagent;Regulation;Role;Scientist;Starvation;System;Testing;Tissues;Trace Elements Nutrition;Work;yeast two hybrid system

PROJECT_TITLE: Bacterial Manganese Homeostasis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MGG-V (81)]


ADMINISTERING_IC: NS

FUNDING_MECHANISM: OTHERS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

PI_NAMEs: CUDKOWICZ, MERIT E (contact)

PROGRAM_OFFICER_NAME: OHAYON, JOAN M

PROJECT_TERMS: Academia;Address;Adult;Affect;Area;Child;Childhood;Clinical;clinical biomarkers;clinical research site;Clinical Trials;Clinical Trials Network;Collaborations;Community Networks;Conceptions;Conduct Clinical Trials;Data Coordinating Center;design;Development;Disease;early phase clinical trial;Ensure;Ethics;FDA approved;first-in-human;Foundations;Funding;Gene Delivery;gene function;gene therapy;gene therapy clinical trial;Gene therapy trial;gene-targeted therapy;Genes;Genetic;Goals;Government;Industry;innovation;Leadership;manufacture;member;Methodology;Monitor;National Institute of Neurological Disorders and Stroke;Nervous System Disorder;Neurosciences;novel;Outcome Measure;Persons;Phase;Phase I Clinical Trials;Privatization;Procedures;Process;Processed Genes;programs;Publishing;Rare Diseases;Regulatory Affairs;Reporting;Research Personnel;Role;Safety;Site;Standardization;targeted therapy trials;Therapeutic;therapeutic development;Therapeutic Studies;Therapy Clinical Trials;therapy development;Translating;trial design;trial planning;Update;web site;Work

PROJECT_TITLE: Gene Therapy Consortium (GTC) for Gene-Based Clinical Trials Conducted within NeuroNEXT


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Eating Disorders;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Mental Illness;Nutrition;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Precision Medicine;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Women's Health Research

ORG_CITY: LOUISVILLE

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF LOUISVILLE

ORG_STATE: KY

PHR: Project Narrative Five percentage of pregnant women have clinically severe disordered eating symptoms, with devastating consequences for both mother and infant, and high societal cost. This proposed research will identify which disordered eating symptoms are most problematic and frequent for driving disordered eating in pregnant and postpartum women, and develop and test interactive, relevant, personalized digital interventions for this high-risk population. This research has significant public health relevance to provide the first highly accessible digital personalized self- guided therapeutic to address the unique challenges that pregnant and postpartum women with disordered eating face and is relevant to NIH’s and IDeA strategic initiatives to develop personalized intervention and treatments, and to provide better healthcare access for women and infants.

PI_NAMEs: BICKFORD, MARTHA E (contact)

PROGRAM_OFFICER_NAME: ZHOU, YANG

PROJECT_TERMS: Address;Algorithms;Anemia;Anxiety;Anxiety Disorders;associated symptom;Automobile Driving;Binge Eating;Birth;body dissatisfaction;career;Caring;Cellular Phone;Cessation of life;Chronic;Clinical;community intervention;Computer software;Congenital Abnormality;cost;Data;Death Rate;Defect;Depressive disorder;digital;digital intervention;digital treatment;Disproportionately impacts women;Eating;Eating Disorders;Emotional;Evidence based intervention;experience;Face;food restriction;Frequencies;Fright;Funding;Growth;Health;health care availability;Health Services Accessibility;Hemorrhage;High Prevalence;high risk;high risk population;High Risk Woman;Impairment;Improve Access;improved;Infant;Infant Health;infant outcome;Insurance;Intervention;Life;Low Birth Weight Infant;maternal outcome;Mental Depression;Mental disorders;Mental Health;Mentorship;Methods;Modeling;Monitor;Morning Sickness;mortality;Mothers;novel;parent grant;Pathological anxiety;Pathology;personalized intervention;personalized medicine;physical conditioning;physical impairment;Population;post pregnancy;postpartum complications;postpartum outcome;Postpartum Period;Postpartum Women;Precision therapeutics;Pregnancy;Pregnancy Complications;Pregnancy Outcome;Pregnant Women;Premature Birth;pressure;programs;Provider;Psyche structure;public health relevance;purge;Quality of life;Randomized, Controlled Trials;Recommendation;recruit;reduce symptoms;Reporting;reproductive;Research;Research Personnel;response;Risk;Risk Reduction;Sleep disturbances;smartphone based assessment;societal costs;Spontaneous abortion;Students;symptom treatment;Symptoms;System;Testing;Therapeutic;Training;Treatment Efficacy;United States;United States National Institutes of Health;user friendly software;Vomiting;Weight;Weight Gain;Woman;Women's Health;Work

PROJECT_TITLE: KY INBRE NOSI Supplement: Identification of Personalized Treatment Targets in Pregnant and Postpartum Women


NIH_SPENDING_CATS: Biotechnology;Genetics;Lung;Neonatal Respiratory Distress;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: IOWA CITY

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Narrative Completing the proposed studies will provide an important proof of concept for a gene addition therapy for ABCA3 deficiency. We will gain new insights into how ABCA3 mutations alter the biology of human alveolar type 2 epithelial cells. In addition to developing a therapeutic strategy for this currently untreatable disease, these studies may also provide a platform for the treatment of other diseases of the surfactant system affecting newborns.

PI_NAMEs: MCCRAY, PAUL B (contact)

PROGRAM_OFFICER_NAME: SHARMA, KARLIE ROXANNE

PROJECT_TERMS: A549;ABCA3 gene;Address;Affect;Air;airway surface liquid;Alveolar;alveolar lamellar body;ATP Hydrolysis;autosome;Baculoviruses;Biological;Candidate Disease Gene;Cell Differentiation process;Cell Line;Cell model;Cell Physiology;Cells;Childhood;Complement;Complementary DNA;Confocal Microscopy;Cyclic AMP;cytokine;Disease;endoplasmic reticulum stress;Ensure;Epithelial Cells;Foundations;functional restoration;Gene Expression Profiling;gene therapy;Gene Transfer;gene-editing approach;Genes;Genetic;genetic variant;Glycoproteins;Goals;HIV;Human;Human Biology;human induced pluripotent stem cells;In Vitro;in vitro Model;in vivo;induced pluripotent stem cell;Inflammatory;insight;Interstitial Lung Diseases;Length;Lentivirus Vector;lipidomics;Liquid substance;loss of function;Lung;Lung Transplantation;Measurement;Membrane;Metabolism;Modeling;monolayer;Mus;mutant;Mutation;Neonatal Respiratory Distress;Newborn Infant;NF-kappa B;Phenotype;Phospholipids;Physiological;Preparation;prevent;Privatization;Production;progenitor;protein expression;Proteins;Pulmonary Fibrosis;Pulmonary Surfactants;Quantitative Reverse Transcriptase PCR;rare variant;Signal Transduction;stem cells;Structure;Surface Tension;surfactant;surfactant deficiency;surfactant production;System;Therapeutic;transcriptome sequencing;transcriptomics;Transgenes;Transmission Electron Microscopy;tubular myelin;Variant;vector;Viral Vector;Visualization;Western Blotting

PROJECT_TITLE: Impact of ATP-binding cassette A3 (ABCA3) mutations on alveolar type 2 cell function and genetic complementation

STUDY_SECTION_NAME: Special Emphasis Panel[ZTR1 RD-8 (01)]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Mental Health;Mental Illness;Neurosciences;Rehabilitation;Serious Mental Illness

ORG_CITY: NEW HAVEN

ORG_DEPT: PSYCHIATRY

ORG_NAME: YALE UNIVERSITY

PHR: Project Narrative Borderline Personality Disorder (BPD) is a common and disabling psychiatric disorder; gold standard treatments leave many patients with ongoing symptoms and profound socio-occupational deficits. Mindfulness training is at the core of one of the best-evidenced BPD treatments, Dialectical Behavior Therapy (DBT), and mediates some of the therapeutic change seen with treatment. Accordingly, the proposed research will investigate whether an innovative mindfulness-based real-time fMRI neurofeedback intervention elicits change in the brain circuits associated with mindfulness to improve clinical outcomes in adults with BPD undergoing DBT.

PI_NAMEs: FINEBERG, SARAH K (contact);WHITFIELD-GABRIELI, SUSAN

PROGRAM_OFFICER_NAME: TALKOVSKY, ALEXANDER MAXWELL

PROJECT_TERMS: Adopted;Adult;Aftercare;Amygdaloid structure;Area;Articulation;Awareness;Borderline Personality Disorder;Boston;Brain;brain circuitry;cingulate cortex;Clinical;clinical application;clinical efficacy;Clinical Research;Clinical Trials;clinically significant;cognitive control;comorbidity;completed suicide;Control Groups;Data;Development;Dialectical behavior therapy;Disabling;Double-blind trial;Elements;emotional distress;Enrollment;evidence base;Feedback;follow-up;Foundational Skills;Foundations;Functional disorder;Functional Magnetic Resonance Imaging;functional MRI scan;Future;Hour;improved;Impulsivity;innovation;Intervention;Knowledge;Learning;Lived experience;Measures;Medial;Mediating;Medical;Mental disorders;Mind;mindfulness;mindfulness meditation;Mindfulness Training;Monitor;Moods;neural;neural correlate;neurofeedback;neuropsychiatry;Neurosciences;novel strategies;novel therapeutics;Occupational;Outcome;Patient Selection;Patients;Pattern;Perception;Persons;Pharmaceutical Preparations;Phase;Population;Prefrontal Cortex;Prevalence;primary endpoint;Program Evaluation;Protocols documentation;Psyche structure;Psychotherapy;Randomized;Recovery of Function;recruit;reduce symptoms;Research;response;Rest;Sampling Studies;secondary outcome;Severities;Site;skills;Social Functioning;standard care;Surveys;Symptoms;Testing;Therapeutic;therapy development;Time;Training;treatment group;trial design;Work

PROJECT_TITLE: Mindfulness-based Neurofeedback to augment DBT psychotherapy for adults with Borderline Personality Disorder (MIND-BPD)


NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Project Narrative This proposal has direct public health relevance since it proposes novel strategies to prevent and treat heart failure which is a major public health problem with a worldwide prevalence of 38 million. By identifying the underlying mechanisms of heart failure, our studies should allow rational development of effective therapeutic approaches to prevent myocardial fibrotic remodeling and heart failure. Thus, the proposed research is relevant to the part of NIH's mission that pertains to developing fundamental knowledge that will help to reduce the burdens of heart diseases worldwide.

PI_NAMEs: LAL, HIND  (contact)

PROGRAM_OFFICER_NAME: ADHIKARI, BISHOW B

PROJECT_TERMS: Acceleration;adenoviral mediated;Adenovirus Vector;Adult;Basic Science;Bioinformatics;Biology;Cardiac;Cardiac Myocytes;Cardiology;Circulation;coronary fibrosis;Data;design;Development;Embryo;Fibroblasts;Fibrosis;Functional disorder;Funding;gain of function;Gene Targeting;gene therapy;genetic manipulation;Goals;Grant;Heart;Heart Diseases;Heart failure;heart function;Heart Injuries;homeodomain;in vitro Assay;in vivo;inhibitor;Injury;insight;ischemic injury;Journals;Knockout Mice;Knowledge;Literature;loss of function;Mediating;Mission;Modeling;Molecular;mouse model;Mus;Myocardial;Myocardial dysfunction;Myocardial Infarction;Myocardial Ischemia;Myofibroblast;novel;novel strategies;Organ;Osmosis;Pathway interactions;pharmacologic;Phenotype;Phosphotransferases;Play;Prevalence;prevent;profibrotic cytokine;Profibrotic signal;Progress Reports;Protein Kinase Interaction;Protein-Serine-Threonine Kinases;Public Health;public health relevance;Publications;Publishing;Pump;repaired;Reporting;Research;Role;Signal Transduction;small hairpin RNA;therapeutic target;therapeutically effective;tool;transcriptome;United States National Institutes of Health;virtual

PROJECT_TITLE: Novel Mechanisms of Cardiac Function and Dysfunction

STUDY_SECTION: MPPB

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology B Study Section[MPPB]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Neurodegenerative;Neurosciences;Rare Diseases

PHR: Project Narrative: Pelizaeus Merzbacher Disease (PMD) is a rare (1.9 per 100,000 live births in the United States) X-linked hypomyelinating leukodystrophy caused by pathogenic variants in PLP, which encodes proteolipid protein 1 (PLP1). As therapies emerge there is an urgent need for tools to discriminate disease severity in PMD early in the disease course, which is often the optimum window for clinical trial enrollment. In our project, we propose to develop a new PMD Severity Scale with face and construct validity through an informed consensus building approach among experts and validated for prospective application for its, validity and determine its context of use in future clinical trials.

PI_NAMEs: GAVAZZI, FRANCESCO  (contact)

PROGRAM_OFFICER_NAME: SURPRIS, MARIPIERRE PAYEN

PROJECT_TERMS: Adaptive Behaviors;Address;Affect;Age;Birth;Characteristics;Classification;clinic ready;Clinical;clinical outcome assessment;Clinical Research;clinical trial enrollment;clinical trial readiness;Clinical Trials;Clinical Trials Network;cohort;Communication;Consensus;Data;data integration;Dependence;design;Development;Disease;Disease Marker;disease natural history;Disease stratification;disorder subtype;Documentation;Evaluation;Event;Exclusion Criteria;Face;Floor;functional disability;Funding;Future;Genotype;Goals;Individual;Industry;Infrastructure;integration site;interest;leukodystrophy;Link;Live Birth;male;Manuals;Measures;Medical;Medical Records;member;Monitor;Motor;Natural History;Onset of illness;Outcome;Pathogenicity;patient advocacy group;Pelizaeus-Merzbacher Disease;Phenotype;Prevalence;Process;prospective;Prospective cohort;Proteins;Proteolipids;Rare Diseases;Reporting;Severities;Severity of illness;standardize measure;Stratification;symposium;System;tool;tool development;United States;Validation;validation studies;Variant;virtual;working group

PROJECT_TITLE: Design and Validation of a Pelizaeus Merzbacher Disease (PMD) Severity Scale

STUDY_SECTION_NAME: Special Emphasis Panel[ZTR1 RD-3 (02)]


NIH_SPENDING_CATS: Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Lung;Neurosciences;Physical Injury - Accidents and Adverse Effects;Prevention

ORG_CITY: BALTIMORE

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE … When a person experiences heart and lung failure, he/she may require a life-saving treatment called Extracorporeal Membrane Oxygenation (ECMO). ECMO is accomplished by hooking up the patient to a machine that functions like an extra set of heart and lungs, thus allowing the patient to recover their own heart and lung function while being supported by an ECMO machine. Unfortunately, ECMO support often is associated with brain injury leading to major disability or death. Our work will investigate the cause of this brain injury and ultimately, if we are correct, help avoid or decrease it. Using an innovative brain imaging system called “portable MRI” that can be performed at the patient’s bedside, as well as blood tests that can detect early on ongoing brain insults, we will examine whether rapid and large reductions of carbon dioxide levels in the blood contribute to ECMO-related brain injury.

PI_NAMEs: CHO, SUNG-MIN  (contact);WHITMAN, GLENN JOSEPH ROBERT

PROGRAM_OFFICER_NAME: BROWN, JEREMY

PROJECT_TERMS: Acidosis;Acute;Acute Brain Injuries;Address;Anticoagulation;Biological Assay;Biological Markers;Blood;Blood flow;Blood gas;Blood Tests;Brain;Brain imaging;Brain Injuries;brain magnetic resonance imaging;Cannulations;Carbon Dioxide;Cardiopulmonary;cerebral autoregulation;Cerebral Ischemia;Cerebrovascular Circulation;Cerebrum;Cessation of life;clinical practice;Clinical Trials;Cognition;Complication;Data;design;Detection;Development;diagnostic tool;diagnostic value;disability;Dose;Early Diagnosis;Enrollment;Event;experience;Extracorporeal Membrane Oxygenation;Failure;Frequencies;Functional disorder;Future;Gases;Goals;Head;Heart;Heart failure;heart function;Hemorrhage;high reward;high risk;Hour;Hypercapnia;Hypocapnia;Hypoxic-Ischemic Brain Injury;Image;imaging system;Impairment;improved;indexing;Information Systems;innovation;Intervention;Intracranial Hemorrhages;Ischemia;ischemic injury;Ischemic Stroke;Life;Light;Lung;lung failure;magnetic field;Magnetic Resonance Imaging;Measurement;Measures;Mediator;Membrane Oxygenators;Metabolic;mortality;neurofilament;neuroimaging;Neurologic;Neurological outcome;Neuronal Injury;Neurons;neuropsychiatry;Outcome;Outcome Assessment;Oxygen;Oxygen saturation measurement;Oxygenators;Patient Outcomes Assessments;Patients;Perfusion;Persons;Physiological;Physiology;Plasma;portability;preclinical study;pressure;prospective;Prospective Studies;Proteomics;pulmonary function;Refractory;Regulation;Research;Respiratory Failure;Safety;Sampling;Serum;Solid;System;tau Proteins;Technology;Testing;Therapeutic;Time;United States;vasoconstriction;Vasodilator Agents;Venous;Work;X-Ray Computed Tomography

PROJECT_TITLE: DELTA ECMO ABI study (Assessing Acute Brain Injury after Rapid Reduction of PaCO2 upon ECMO Cannulation using Portable MRI and Biomarkers)

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


ADMINISTERING_IC: ES

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

ORG_CITY: AMES

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: IOWA STATE UNIVERSITY

PHR: Project Narrative: Understanding ovarian cellular signaling changes that are induced by obesity is critical to improve female fertility and to minimize risk from alkylating chemical exposures. These tools are critical for maintenance and improvement of reproductive health in girls and women.

PI_NAMEs: KEATING, AILEEN FRANCES (contact)

PROGRAM_OFFICER_NAME: SCHUG, THADDEUS

PROJECT_TERMS: Address;Adult;Affect;AHR gene;Alkylating Agents;Amenorrhea;Anthracenes;Antioxidants;Area;Aromatic Polycyclic Hydrocarbons;ataxia telangiectasia mutated protein;ATM activation;Birth Rate;carcinogenesis;Chemical Exposure;Chemicals;ChIP-seq;Chronic;Complication;Conceptions;Congenital Abnormality;Coronary heart disease;Couples;Data;Development;Diet;dimethylbenzanthracene;DNA Adducts;DNA Damage;DNA Repair;DNA Repair Gene;Environment;environmental chemical exposure;Enzymes;Estrus;experience;Exposure to;Fatty acid glycerol esters;feeding;Female;female fertility;Fertility;Foundations;Functional disorder;Generations;girls;Goals;Health;histone modification;Hyperphagia;implantation;improved;in utero;Infertility;innovation;interest;Investigation;Learning;Life;Light;Maintenance;Malignant neoplasm of ovary;Mental Depression;Metabolic;Metabolic Biotransformation;Metabolism;Methylation;Minority Groups;Minority Women;Mission;Modeling;Mus;National Institute of Environmental Health Sciences;Neonatal;Non-Insulin-Dependent Diabetes Mellitus;novel;Obese Mice;Obesity;offspring;oocyte quality;Osteoporosis;Outcome;Ovarian;ovarian damage;Ovarian Follicle;Ovary;ovotoxicant;ovotoxicity;Oxidative Stress;Oxidative Stress Induction;Pathway interactions;Periodicity;Phenotype;Physiological;PIK3CG gene;Postmenopause;Pregnancy;Premature Menopause;prepuberty;promoter;protein metabolism;Proteins;Puberty;Public Health;Publishing;Reactive Oxygen Species;repaired;reproductive;Reproductive Health;reproductive success;Research;response;Risk;risk minimization;Role;Signal Transduction;Societies;socioeconomics;Solid;Specific qualifier value;Spontaneous abortion;Subfecundity;sugar;Thinness;tool;transcriptome sequencing;Woman;Women's Health;women's reproductive health;Work

PROJECT_TITLE: Investigating obesity-induced altered ovarian intracellular signaling

STUDY_SECTION: CMIR

STUDY_SECTION_NAME: Cellular, Molecular and Integrative Reproduction Study Section[CMIR]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Immunotherapy;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human

ORG_CITY: NEW YORK

ORG_DEPT: SURGERY

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: PROJECT NARRATIVE CD8+ T cells are critical to the anti-tumor immune response, with therapies targeting these cells providing substantial clinical benefit. A specific subset of these cells, marked by expression of TCF1, is critical to their therapeutic effect; however, how this population is generated and maintained remains unclear, limiting its potential. This project aims to identify core characteristics of these TCF1+ cells, as well as identify and validate key proteins controlling their generation and anti-tumor function for future in depth analysis.

PI_NAMEs: MARKOWITZ, GEOFFREY JOSEPH (contact)

PROGRAM_OFFICER_NAME: BROWN, PATRICK

PROJECT_TERMS: Affect;Affinity;anti-PD1 therapy;anti-tumor immune response;Antigens;Cancer Model;Candidate Disease Gene;Carbon;Career Mobility;CD8-Positive T-Lymphocytes;Cell Differentiation process;Cells;Cellular Metabolic Process;Characteristics;Clinical;Coculture Techniques;CRISPR screen;CRISPR/Cas technology;cytokine;cytotoxic;Data;Drug usage;enzyme pathway;Enzymes;exhaust;extracellular;Flow Cytometry;Future;Gene Expression Profile;Generations;Genetic Transcription;Glycolysis;Goals;Heterogeneity;Human;immune checkpoint blockade;Immunocompetent;Immunotherapeutic agent;Immunotherapy;In Vitro;in vivo;inhibitor;inhibitory surface receptor;inorganic phosphate;Ligation;Link;Maintenance;Malignant neoplasm of lung;Measures;Mediating;Memory;Metabolic;Metabolic Pathway;Metabolism;metabolomics;Mouse Strains;Mus;Organoids;Pathway interactions;Patients;Pentosephosphate Pathway;Pharmaceutical Preparations;pharmacologic;Phenocopy;Phenotype;Population;Population Distributions;Production;progenitor;Property;Proteins;Reporter;Research Personnel;response;small molecule;Sorting;stem;stem cell population;stem cells;stem-like cell;System;T cell differentiation;T cell therapy;T cell transcription factor 1;T-Cell Activation;T-Cell Receptor Genes;T-Lymphocyte;targeted agent;targeted treatment;TCF Transcription Factor;Testing;Therapeutic;Therapeutic Effect;Therapeutically Targetable;transcription factor;transcriptome sequencing;transcriptomics;Transgenic Organisms;Treatment Efficacy;tumor;Tumor Cell Line;Tumor Immunity;Work

PROJECT_TITLE: Modulation of CD8+ T cell differentiation and anti-tumor immunity by metabolic manipulation

STUDY_SECTION_NAME: Special Emphasis Panel[ZTR1 CI-4 (01)]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Dissemination and Implementation Research;Eye Disease and Disorders of Vision;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurosciences;Prevention;Primary Health Care;Rural Health;Social Determinants of Health;Telehealth

ORG_CITY: MADISON

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE Teleophthalmology using retinal cameras in primary care clinics has been shown to improve diabetic eye screening rates and visual outcomes, but remains greatly underutilized in the U.S. This multi-center randomized controlled trial proposes to test the effectiveness and generalizability of a promising implementation program (I- SITE: Implementation to Sustain Impact in Teleophthalmology) for sustaining increased diabetic eye screening rates using teleophthalmology in rural health systems. This research seeks to identify methods for successful integration of telemedicine technology into rural primary care workflows to prevent blindness from diabetes, the leading cause of blindness among working-age U.S. adults.

PI_NAMEs: LIU, YAO  (contact)

PROGRAM_OFFICER_NAME: LE, JIMMY TOAN

PROJECT_TERMS: acceptability and feasibility;Acute;Address;Adherence;Adult;Affect;Age;American;Area;Blindness;care providers;Caring;clinical practice;Clinical Trials;Cluster randomized trial;Communities;Data;design;Diabetes Mellitus;diabetic;Diabetic Retinopathy;Early Diagnosis;Early treatment;Effectiveness;effectiveness evaluation;effectiveness testing;Elements;evidence base;Eye;Face;Future;Goals;Guidelines;Health Services Accessibility;Health system;Health Technology;Healthcare Systems;Human Resources;implementation cost;implementation evaluation;implementation measures;improved;insight;Insurance Coverage;Interview;K-Series Research Career Programs;Knowledge;Measures;meetings;Mentored Patient-Oriented Research Career Development Award;Methods;National Eye Institute;Outcome;Outcome Measure;Patients;pilot test;Prevalence;prevent;Primary Care;primary care clinic;primary care provider;Primary Health Care;primary outcome;programs;Public Health;Randomized, Controlled Trials;Recording of previous events;Research;Retina;Retinal Diseases;Risk;Risk Reduction;Rural;rural Americans;Rural Community;Rural Health;rural patients;Rural Population;scale up;screening;Screening Result;secondary outcome;Strategic Planning;Structure;Technology;telehealth;Telemedicine;teleophthalmology;Testing;Time;Translating;Translations;Travel;treatment as usual;United States National Institutes of Health;Urban Population;urban underserved;Vision;Visual;Visual impairment;Work

PROJECT_TITLE: I-TRUST: Implementation of Teleophthalmology in Rural Health Systems Study


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Clinical Research;Uterine Cancer;Women's Health Research

ORG_CITY: OMAHA

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: Project Narrative: Overall Impactful biomedical research requires an increasing level of sophistication in data acquisition and analysis. The goal of the Nebraska Center for Molecular Target Discovery and Development is to facilitate biomedical research university-wide by providing mentoring/guidance and underwriting the cost of access to cutting-edge techniques that will catalyze the identification, validation, and development of potential therapies against molecular targets for clinically important diseases.

PI_NAMEs: LEWIS, ROBERT E. (contact)

PROGRAM_OFFICER_NAME: BASKIR, RUBIN SAM

PROJECT_TERMS: analytical method;Appointment;Award;Awareness;Basic Science;Belief;bench to bedside;Biological;Biological Models;Biology;Biomedical Research;Career Mobility;Cells;Centers of Research Excellence;Chemicals;Classification;Clinical;Collaborations;college;cost;Data;data acquisition;Data Analyses;Data Set;Dedications;Development;Discipline;Disease;Endometrial Carcinoma;Evaluation;expectation;experience;Faculty;faculty support;Financial Support;Funding;Future;Generations;genetic analysis;Genomics;Goals;Grant;Health;Homeostasis;Human;improved;Infrastructure;inhibitor;insight;Institution;interest;Investments;Journals;Medical center;member;Mentors;Modernization;Molecular;Molecular Analysis;Molecular Target;Nebraska;novel;novel therapeutics;operation;Organoids;Phase;Pre-Clinical Model;preclinical development;programs;Protac;Protein Phosphatase 2A Regulatory Subunit PR53;Reagent;Research;research and development;Research Personnel;Research Project Grants;Research Support;Resource Sharing;Resources;skill acquisition;small molecule;success;System;Taxes;Teacher Professional Development;Techniques;Technology;technology development;Therapeutic;therapeutic development;therapeutic target;Time;Training;transcriptomics;undergraduate student;Universities;Validation;Vision

PROJECT_TITLE: Targeting Endometrial Cancer with Novel Small Molecule Modulators of PP2A


ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: Project Narrative Photoreceptors are the main detectors of light that relay visual information to the brain. This proposal investigates the key molecular interactions that mediate selective wiring of photoreceptors to their respective synaptic targets. The long-term goal of this research is to uncover the molecular basis of retinal wiring in order to devise new forms of therapies to treat and restore vision.

PI_NAMEs: ZUNIGA-SANCHEZ, ELIZABETH  (contact)

PROGRAM_OFFICER_NAME: WRIGHT, CHARLES BAKER

PROJECT_TERMS: Address;Adhesives;Axon;B-Lymphocytes;Binding;Bipolar Neuron;Blindness;Brain;Cell Adhesion Molecules;cell type;Central Nervous System;Clustered Regularly Interspaced Short Palindromic Repeats;CNTNAP1 gene;Complex;Cone;contactin;Data;Defect;Degenerative Disorder;Dendrites;detector;Development;developmental disease;Ectopic Expression;Electroporation;experimental study;Family;gain of function;genetic manipulation;Goals;horizontal cell;in vivo;Knowledge;Label;Light;loss of function;Mediating;Molecular;Nervous System Disorder;Neural Cell Adhesion Molecule L1;neural circuit;neurofascin;Neurons;NRCAM gene;organizational structure;Pathway interactions;Patients;Pattern;Photoreceptors;postsynaptic;Process;protein expression;Research;response;Retina;Retinal Cone;Retinal Diseases;retinal rods;rho;Rod;sight restoration;Specific qualifier value;Specificity;Synapses;synaptogenesis;Techniques;Testing;Transgenic Mice;transmission process;Vertebrate Photoreceptors;Visual;visual information;Work

PROJECT_TITLE: Deciphering the molecular mechanisms in photoreceptor wiring


NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Eye Disease and Disorders of Vision;Neurosciences;Rehabilitation

PHR: NARRATIVE Within a decade, many blind individuals are likely to be offered a wide range of options for sight restoration - including electronic prostheses, gene therapy and optogenetics. However the vision provided by almost all of these technologies will differ substantially from normal sight. The question of this proposal is – What role can cortical plasticity play in helping patients make use of the artificial visual input provided by sight recovery technology?

PI_NAMEs: BOYNTON, GEOFFREY M;FINE, IONE  (contact)

PROGRAM_OFFICER_NAME: WIGGS, CHERI

PROJECT_TERMS: Accommodation phosphene;Adult;Animal Model;Architecture;Axon;Biological;Brain;Cells;Clinical Trials;Code;Compensation;Computer Models;Data;design;Development;Device Designs;Devices;Electrodes;Electronics;experience;Eye;Eye Movements;fovea centralis;Fruit;ganglion cell;gene therapy;Gene therapy trial;Goals;Human;human data;Implant;Individual;infancy;insight;Kinetics;Learning;Leber's amaurosis;Light;Manufacturer;Modeling;Motion;neural;Neurons;neurophysiology;novel;Ocular Dominance;Ocular dominance columns;Ocular Prosthesis;Optic Nerve;optogenetics;Participant;Patients;Perceptual learning;Physiological;Play;Population;Prosthesis;Psychophysics;receptive field;Recovery;Reporting;Research;Resolution;response;Retina;retina implantation;Retinal Ganglion Cells;retinal stimulation;Role;Route;sight restoration;spatiotemporal;Surface;Technology;Testing;Thinking;Training;Video Games;virtual patient;Vision;Visual;Visual Perception;Visually Impaired Persons;Work

PROJECT_TITLE: Learning to see again: biological constraints on cortical plasticity and the implications for sight restoration technologies

STUDY_SECTION: SPC

STUDY_SECTION_NAME: Mechanisms of Sensory, Perceptual, and Cognitive Processes Study Section[SPC]


NIH_SPENDING_CATS: Assistive Technology;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Eye Disease and Disorders of Vision;Neurosciences

PHR: PROJECT NARRATIVE The current project examines the neural basis of Braille reading in proficient congenitally blind adults, late blind readers with varying degrees of proficiency and blind children learning to read, using fMRI and high-density diffusion imaging (dMRI). These studies of Braille literacy provide insights into human brain plasticity and the neural basis of culture.

PI_NAMEs: BEDNY, MARINA  (contact)

PROJECT_TITLE: Neural basis of Braille literacy in blind adults and children


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: COLLEGE PARK

ORG_DEPT: BIOLOGY

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

PHR: Project Narrative Identification of the synaptic loci that control critical periods of enhanced plasticity is required to improve the success of treatments for amblyopia. Here we propose a series of experiment to test a provocative new model in which the initial response to monocular deprivation during the critical period is a rapid, transient and synapse-specific elimination of local L2/3 PyràPV INs synaptic connections. We propose that this early elimination of local L2/3 PyràPV INs excitatory synapses is obligatory for subsequent changes in ocular dominance and spatial acuity induced by monocular deprivation.

PI_NAMEs: KIRKWOOD, ALFREDO ;MURASE, SACHIKO  (contact)

PROGRAM_OFFICER_NAME: FLANDERS, MARTHA C

PROJECT_TERMS: Adult;Amblyopia;area striata;Biological Models;cellular targeting;Consensus;Control Locus;critical period;Data;Development;Distal;Dominant-Negative Mutation;Excitatory Synapse;experience;experimental study;Eye;Glutamates;hippocampal pyramidal neuron;improved;in vivo;insight;Interneurons;meter;Modeling;Molecular Genetics;Molecular Target;monocular deprivation;multidisciplinary;Mus;neural;neuronal pentraxin;Neurons;novel;Ocular Dominance;Output;Parvalbumins;permissiveness;Physiological;Physiology;postnatal;predictive modeling;prevent;Pyramidal Cells;receptive field;recruit;Regulation;Research;response;Series;Shapes;Signal Transduction;Stimulus;Structure;success;Synapses;Synaptic plasticity;Testing;tool;Vision;Visual Acuity;Visual Cortex

PROJECT_TITLE: Reversible activation of critical period plasticity in visual cortex


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Emerging Infectious Diseases;Immunotherapy;Infectious Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

PHR: Project Narrative The use of “off-the-shelf” third-party virus specific T-cell (VST) therapy has become an increasingly available and effective treatment for the management of viral infections after allogeneic hematopoietic stem cell transplant. In this study, we aim to use samples from VST recipients to improve mechanistic understanding of how patient-, product-, and virus- specific factors mediate treatment success and failure.

PI_NAMEs: RUBINSTEIN, JEREMY D (contact)

PROGRAM_OFFICER_NAME: DI FRONZO, NANCY L

PROJECT_TERMS: Adenoviruses;Allogenic;Anti-viral Agents;Antigen Presentation;Antigens;Area;BK Virus;Blood;cell bank;Cell Count;Cell Line;Cell Therapy;Cells;Child;Childhood;Clinical;Clinical Trials;Clone Cells;Collaborations;Complication;Conserved Sequence;Cryopreservation;Cytomegalovirus;Cytotoxic T-Lymphocytes;Data;Defect;donor stem cell;Double Stranded DNA Virus;effective therapy;effector T cell;Enrollment;Epitope Mapping;Epitopes;experimental study;Failure;Future;genome sequencing;Hematopoietic Stem Cell Transplantation;HLA Antigens;Hospitalization;Human Herpesvirus 4;Immunocompromised Host;Immunophenotyping;improved;improved outcome;in silico;Infection;infection management;Infusion procedures;Institution;Interferon Type II;Intravenous infusion procedures;Laboratories;Mediating;Medical center;Methods;Morbidity - disease rate;mortality;participant enrollment;Patients;Pattern;Peptides;peripheral blood;Peripheral Blood Mononuclear Cell;Plasma;Population;Resistance;resistance mechanism;response;Role;Safety;Sampling;Site;Source;success;symptomatic improvement;T cell therapy;T-Cell Receptor;T-Lymphocyte;T-Lymphocyte Subsets;Testing;Therapeutic Index;Toxic effect;Transplantation;Treatment Failure;Urine;Viral;Viral Genome;viral genomics;Viral Load result;Viral Physiology;viral resistance;Viremia;Virus;Virus Diseases

PROJECT_TITLE: Allogeneic virus-specific T-cell therapy after hematopoietic stem cell transplant: determinants of treatment success and failure

STUDY_SECTION: TTT

STUDY_SECTION_NAME: Transplantation, Tolerance, and Tumor Immunology Study Section[TTT]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Eye Disease and Disorders of Vision;Neurosciences;Regenerative Medicine

ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: Central retinal artery occlusion is an acute emergency that results in retinal cell death via a number of mechanisms. Preventing retinal cells from dying is a major public health necessity. Our objective is to study mesenchymal stem cell secreted extracellular vesicles (EVs) as a therapeutic tool to prevent the loss of vision from central retinal artery occlusion, wherein we plan to develop functionally engineered EVs (FEEs) for retina- specific protective actions.

PI_NAMEs: RAVINDRAN, SRIRAM ;ROTH, STEVEN  (contact)

PROGRAM_OFFICER_NAME: SHEN, GRACE L

PROJECT_TERMS: Acute;Address;Adjuvant;Affect;Alteplase;Animal Model;antagonist;anterior chamber;Anti-Inflammatory Agents;Antiinflammatory Effect;Apoptosis;Apoptotic;Attenuated;Basic Science;Biology;Biomimetics;Blindness;Blood-Retinal Barrier;Cardiac Surgery procedures;Case Series;Cell Death;cell injury;Cell secretion;Cells;Central Retinal Artery Occlusion;cerebrovascular;Characteristics;clinical translation;combat;Cytokine Gene;Cytoprotection;Dermal;Diabetic Retinopathy;disability burden;Disease;Economic Burden;effectiveness evaluation;Elderly;Emergency Situation;Engineering;Enrollment;Event;experimental study;extracellular vesicles;Eye;Face;falls;Filler;Functional dependence;Functional impairment;functional mimics;gain of function;Generations;Growth;human disease;human model;Hyperbaric Oxygen;Hypoxia;Iatrogenesis;Immune response;immunoregulation;In Vitro;in vivo;Incidence;Inflammation;Inflammatory;Injections;innovation;Interruption;Intervention;Intravenous;Ischemia;ischemic injury;knock-down;Knowledge;Laboratories;Long-Term Care;loss of function;Massage;Mediating;Mesenchymal Stem Cells;Methodology;Microglia;MicroRNAs;model development;Modeling;Molecular;Muller's cell;nanovesicle;Natural regeneration;neuroinflammation;Neurons;neuroprotection;novel;overexpression;Paracentesis;Pathway interactions;Patients;Permeability;Physiologic Intraocular Pressure;Play;precision medicine;preconditioning;prevent;Property;protective effect;Public Health;Publishing;randomized, clinical trials;repaired;Reporting;response;restoration;Retina;retinal damage;Retinal Diseases;Retinal Ganglion Cells;retinal ischemia;retinal neuron;Rodent Model;Role;Specificity;stem cells;Stroke;stroke model;success;System;Testing;Therapeutic;thrombolysis;tool;transcriptome sequencing;Translating;translational medicine;Vascular Diseases;Vascular Endothelial Cell;vascular injury;Vision

PROJECT_TITLE: Mesenchymal stem cell extracellular vesicles for ischemic retinal damage

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]


NIH_SPENDING_CATS: Congenital Structural Anomalies;Eye Disease and Disorders of Vision;Pediatric;Primary Immunodeficiencies;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: Hermansky-Pudlak syndrome is a group of genetic disorders that are particularly common in Puerto Rico and are characterized by oculocutaneous albinism, excessive bleeding, and in many cases a fatal lung fibrosis and/or immune deficiency. The symptoms result from the failure to form certain specialized membrane structures, or organelles, within affected cell types. This proposal uses the melanosome, a target organelle within pigment cells, as a model system to understand how the products of the genes that are disrupted in Hermansky-Pudlak syndrome patients normally function together to generate specialized organelles.

PI_NAMEs: MARKS, MICHAEL S (contact);RAPOSO, GRACA GRACA

PROGRAM_OFFICER_NAME: NEUHOLD, LISA

PROJECT_TERMS: 1-Phosphatidylinositol 4-Kinase;Adaptor Protein Complex 2;Adaptor Protein Complex 3;Adaptor Protein Complex Subunits;Adaptor Signaling Protein;Affect;Behavior;Binding;Biochemical;Biogenesis;Biological Models;Blood Platelets;Cell membrane;cell type;Cells;cohort;Complex;Coupled;Cytoplasm;Data;Dissociation;Early Endosome;Electron Microscopy;Endosomes;Enzymes;Epithelial Cells;Eye;Failure;Funding;gene product;Genes;Genetic Diseases;genetic manipulation;Goals;Grant;Hemorrhage;Hermanski-Pudlak Syndrome;Human;Hypopigmentation;Image;imaging approach;immunodeficiency;insight;Integral Membrane Protein;Kinesin;knock-down;Knock-out;Knowledge;Length;Lipids;live cell imaging;Lysosomes;Maps;Melanins;melanocyte;Melanosomes;Membrane;Microscopy;Microtubules;Molecular;Molecular Diagnosis;Motor;mouse model;Mutate;Mutation;Oculocutaneous Albinism;Organelles;Pathway interactions;Patients;phosphatidylinositol 4-phosphate;Phospholipids;Physiological;Pigment Epithelium;Pigments;Process;Protein Isoforms;Protein Sortings;Proteins;Proteomics;Puerto Rico;Pulmonary Fibrosis;rab GTP-Binding Proteins;Recycling;Role;scaffold;Secretory Vesicles;Skin;Sorting;spatiotemporal;Specificity;Structure;Structure of retinal pigment epithelium;Symptoms;System;Testing;Therapeutic;Transmembrane Transport;Tubular formation;Vision

PROJECT_TITLE: Hermansky-Pudlak syndrome and melanosome formation

STUDY_SECTION_NAME: Cell Structure and Function 1 Study Section[CSF1]


NIH_SPENDING_CATS: Cancer

ORG_CITY: CAMBRIDGE

ORG_NAME: BROAD INSTITUTE, INC.

PHR: Despite advances in targeted therapies and immunotherapies, cancer remains a clinical challenge, indicating a need for new targeting modalities. In this proposal, we will determine whether activation of a toxic RNase, SLFN12, is controlled by dimerization, or linking of two SLFN12 proteins together. Our ultimate goal is to investigate whether SLFN12 can be turned into an anti-cancer agent by dimerizing SLFN12 specifically in cancer cells.

PI_NAMEs: GREULICH, HEIDI  (contact)

PROGRAM_OFFICER_NAME: CERO, CHERYL

PROJECT_TERMS: Antineoplastic Agents;Apoptosis;Binding;Biochemical;Biological Markers;cancer cell;Cell Death;Cell Survival;Cells;Chemicals;Clinical;Codon Nucleotides;Complex;Computer Models;Cryoelectron Microscopy;cytotoxic;cytotoxicity;Data;design;dimer;Dimerization;Ectopic Expression;Exhibits;experimental study;Failure;gain of function;Goals;Homodimerization;Immunotherapy;In Vitro;in vitro activity;Induction of Apoptosis;Leucine;Leucine-Specific tRNA;Link;loss of function;Malignant Neoplasms;Measures;Mediating;Messenger RNA;Modality;Modeling;monomer;mutant;Mutation;PDE3A gene product;Phenocopy;Physiological;Point Mutation;Protein Biosynthesis;Protein Synthesis Inhibition;Proteins;Recombinants;Research;response;Ribonucleases;Role;small molecule;Structure;Tacrolimus Binding Proteins;targeted treatment;Testing;Therapeutic;therapeutic development;Translational Repression;Up-Regulation

PROJECT_TITLE: Activation of SLFN12 RNase Activity by Dimerization

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 RTRB-S (M2)]