NIH_SPENDING_CATS: Antimicrobial Resistance;Biotechnology;Genetics;Infectious Diseases;Vector-Borne Diseases

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Parasitic nematodes are the most abundant, diverse, and destructive macroparasites on the planet, placing heavy health burdens on billions of people in developing countries and causing billions of dollars lost annually in crops and livestock. This proposal seeks to identify genes, transcripts, and small molecules involved in emodepside resistance, a promising new anthelmintic with completely uncharacterized resistance mechanisms. Completion of this proposal will identify emodepside resistance genes and establish biochemical mechanisms behind the metabolism of emodepside, which are both needed to implement targeted and effective anthelmintic treatment plans.

PI_NAMEs: SHAVER, AMANDA  (contact)

PROGRAM_OFFICER_NAME: MO, ANNIE X  Y

PROJECT_TERMS: acetylcholine receptor agonist;Animals;antagonist;Anthelmintics;Behavior;benzimidazole;Biochemical;Biochemistry;Biological;Biological Assay;Biology;C. elegans genome;Caenorhabditis elegans;Calcium-Activated Potassium Channel;Candidate Disease Gene;candidate validation;Clinical;Collaborations;combat;CRISPR/Cas technology;Data;Developing Countries;Development;drug efficacy;Drug Exposure;Drug Metabolic Detoxication;drug metabolism;Drug resistance;Enzyme Inhibitor Drugs;Enzymes;experience;experimental study;Exposure to;Family;fitness;Future;Gene Expression;Gene Expression Profile;Gene Frequency;Generations;Genes;Genetic;genetic variant;Genetic Variation;genome editing;genome wide association study;Genomic Segment;Genomics;Health;high throughput screening;Human;improved;inhibitor;interest;Knowledge;Laboratories;Lactones;Link;liquid chromatography mass spectrometry;Livestock;loss of function mutation;Measures;member;Metabolic Biotransformation;Metabolism;metabolomics;Modeling;Molecular;Molecular Target;Multi-Drug Resistance;Mutation;neglected tropical diseases;Nematoda;Nematode infections;Nicotinic Receptors;novel;novel strategies;novel therapeutics;Ocular Onchocerciasis;Onchocerca volvulus;Outcome;Parasite Control;Parasite resistance;Parasites;Parasitic infection;Parasitic nematode;Persons;Pharmaceutical Preparations;Pharmacotherapy;Phenotype;Planets;Play;Poison;Population;programs;Quality Control;Research;Research Proposals;Resistance;resistance allele;resistance gene;resistance mechanism;resistance mutation;response;Role;Sampling;Scientist;small molecule;Statistical Data Interpretation;Testing;Time;Training;Transcript;transcriptome sequencing;treatment planning;treatment strategy;Variant;voltage;Xenobiotics

PROJECT_TITLE: Discovery of the mechanisms of resistance for the anthelmintic emodepside

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F08-L (20)]


ADMINISTERING_IC: CA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: LOS ANGELES

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PHARMACOLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: PROJECT NARRATIVE Our recent studies identified ATAD2 as an up-regulated druggable protein treatment-induced NEPC. Moreover, we demonstrated that ATAD2 inhibitors dramatically suppress NEPC cell and tumor growth. The goals of the study are to test the therapeutic potential of ATAD2 inhibitor alone or in combination therapy settings in pre- clinical models of adeno-CRPC and NEPC and define new mechanisms through which ATAD2 regulates prostate tumorigenesis.

PI_NAMEs: STOYANOVA, TANYA I (contact)

PROGRAM_OFFICER_NAME: GREENBERG, WILLIAM A

PROJECT_TERMS: Advanced Development;advanced disease;advanced prostate cancer;Aftercare;Aggressive Clinical Course;androgen deprivation therapy;androgen independent prostate cancer;Androgen Receptor;Androgens;Binding;Biological Markers;cell growth;Cell Line;Cessation of life;ChIP-seq;Cisplatin;Clinical;Clinical Trials;clinically relevant;cohort;Combined Modality Therapy;deprivation;Development;Diagnosis;Disease;docetaxel;Down-Regulation;experimental study;Future;Gene Deletion;Goals;Growth;hormone therapy;In Vitro;in vivo;inhibitor;Invaded;knock-down;Life Expectancy;Localized Disease;male;Malignant neoplasm of prostate;Malignant Neoplasms;men;migration;Modeling;Molecular;mortality;Neoplasm Metastasis;neuroendocrine phenotype;Neurosecretory Systems;new combination therapies;new therapeutic target;novel;novel therapeutic intervention;novel therapeutics;overexpression;patient derived xenograft model;Patients;Phenotype;Pilot Projects;Platinum Compounds;pre-clinical;Pre-Clinical Model;prostate carcinogenesis;Proteins;Proteomics;Recurrence;Research;Role;Specimen;standard of care;synergism;taxane;Testing;therapeutic candidate;therapeutic evaluation;Therapeutic Intervention;therapeutic target;Time;Tissue Sample;transcriptome;transcriptome sequencing;Treatment Efficacy;tumor;tumor growth

PROJECT_TITLE: Testing ATAD2 as a new therapeutic target for advanced prostate cancer

STUDY_SECTION: MCTA

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics A Study Section[MCTA]


ADMINISTERING_IC: HL

ED_INST_TYPE: GRADUATE SCHOOLS

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Diabetes;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Nutrition;Obesity;Prevention

ORG_CITY: BLACKSBURG

ORG_DEPT: BIOLOGY

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

ORG_STATE: VA

PHR: Project Narrative At present, there is no ideal treatment for type II diabetes, which increases a patient's likelihood of developing cardiovascular disease and its related mortality. This research proposal aims to investigate the molecular pathways through which high fat diet leads to cardiac insulin resistance, as obesity is a major contributor. The insights gained from this study will allow for the advancement of therapies for cardiovascular disease in patients with diabetes.

PI_NAMEs: WHEELER, MASON  (contact)

PROGRAM_OFFICER_NAME: CHEON, YEWON

PROJECT_TERMS: Automobile Driving;Binding;Blood Glucose;burden of illness;Cardiac;Cardiac Myocytes;Cardiovascular Diseases;cardiovascular disorder therapy;Cell Respiration;Chemicals;Chromatin;chromatin immunoprecipitation;Complex;Coronary Arteriosclerosis;Critical Pathways;Data;Data Set;deep sequencing;Development;Diabetes Mellitus;diabetic cardiomyopathy;Diet;DNA;DNA Damage;Dyslipidemias;Fatty acid glycerol esters;Fatty Acids;Gene Expression;Genes;Genetic;Genetic Transcription;genome-wide;genome-wide analysis;genomic locus;Heart;Heart Diseases;Heart failure;High Fat Diet;Hypertension;Impairment;In Vitro;in vivo;inhibitor;insight;Insulin;insulin regulation;Insulin Resistance;insulin sensitivity;insulin sensitivity/resistance;insulin signaling;Investigation;Laboratories;Link;Mediating;Mediator;Mentorship;Messenger RNA;Metabolic;Modeling;Molecular;mortality;mouse model;Mus;mutant;Mutation;Myocardial dysfunction;new therapeutic target;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutics;Nuclear;Obesity;Pathogenesis;Pathology;Pathway interactions;Patient risk;Patients;Polymerase;prevent;protein expression;Proteins;Research;Research Proposals;Resistance;restoration;Risk Factors;RNA Polymerase II;Role;Signal Transduction;Testing;Therapeutic;Training;Transcript;Transcription Initiation Site;Transcriptional Regulation;Translating;Up-Regulation

PROJECT_TITLE: Investigating REDD1 as a mediator of cardiac insulin resistance

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F10A-K (20)]


ADMINISTERING_IC: EY

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Eye Disease and Disorders of Vision;Infectious Diseases;Nanotechnology;Orphan Drug;Rare Diseases;Sexually Transmitted Infections

ORG_CITY: TUCSON

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: PROJECT NARRATIVE Ocular herpes infection is a leading cause of infectious corneal blindness in the world. Current topical antiviral eyedrops available for the management of ocular herpes need to be administered 5-9 times daily. This proposal aims to repurpose adefovir dipivoxil, an off-patent FDA-approved hepatitis B virus DNA polymerase inhibitor, for the treatment of ocular herpes and reformulate ADV into long-acting nanoformulations to achieve once a day topical therapy for effective therapy of ocular HSV infections.

PI_NAMEs: DATE, ABHIJIT A (contact);SHUKLA, DEEPAK

PROGRAM_OFFICER_NAME: MCKIE, GEORGE ANN

PROJECT_TERMS: 3-Dimensional;Acyclovir;adefovir;adefovir dipivoxil;Affect;Anatomy;Anti-viral Agents;anti-viral efficacy;Anti-viral Therapy;Antibiotics;Biological Availability;Blindness;C10;Categories;Chronic Hepatitis B;Cidofovir;Clinic;Clinical;clinical development;Cornea;corneal epithelium;Corneal Ulcer;Data;Development;Diphosphates;DNA Polymerase Inhibitor;DNA Viruses;Dose;Drug Kinetics;Drug resistance;effective therapy;emerging virus;Endothelium;Epithelial Cells;Epithelium;Evaluation;Eye;Eye Infections;Eyedrops;Family suidae;FDA approved;Film;Formulation;Frequencies;Friends;Fumarates;Ganciclovir;Gel;Half-Life;Hepatitis B Virus;Herpes Simplex Infections;Herpesviridae Infections;Herpesvirus 1;Herpetic Keratitis;Hour;Human;Human Herpesvirus 2;human tissue;hydrophilicity;Hydrophobicity;improved;In Vitro;in vivo;Infection;Infection Control;Keratitis;Location;meter;Modeling;Morbidity - disease rate;mouse model;Moxifloxacin;Mucins;Mus;nano;nanoformulation;nanomedicine;novel therapeutics;nucleoside analog;Nucleosides;off-patent;Oryctolagus cuniculus;Patient Compliance;Patients;Permeability;Pharmaceutical Preparations;phosphonate;Poloxamers;Prodrugs;Recurrence;Research;Resistance;resistant strain;Retroviridae;Safety;Salts;Simplexvirus;Sodium Chloride;Standardization;Structure;Suspensions;tear proteins;Tenofovir;therapy adherence;therapy outcome;Tissue Model;topical antiviral;Topical application;Translating;Treatment Efficacy;Trifluridine;United States;Viral;Viral Physiology;Visual

PROJECT_TITLE: Repurposing and reformulation of adefovir dipivoxil for improved topical treatment of herpes simplex virus infection of the eye

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 DCAI-U (90)]


NIH_SPENDING_CATS: Bioengineering;Breast Cancer;Cancer;Genetics;Women's Health Research

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative During division, cells must accurately segregate their genome into two equal daughter cells, as errors can impact cell health and lead to diseases such as cancer. The anaphase spindle is the structure responsible for actively separating sister chromatids, and here I will probe its mechanical properties in live mammalian cells and ask how overexpression of the oncogenic protein PRC1 can disrupt its proper functioning. By improving our understanding of anaphase mechanics in healthy and cancer contexts, this work may provide future avenues of therapeutic development.

PI_NAMEs: MULLIN-BERNSTEIN, ZACHARY  (contact)

PROGRAM_OFFICER_NAME: ODEH, HANA M

PROJECT_TERMS: Anaphase;Aneuploidy;Architecture;Automobile Driving;Behavior;Binding Proteins;biophysical tools;Breast Cancer Cell;cancer cell;Cancer cell line;Cell division;Cells;Chromosomal Instability;Chromosome Segregation;Chromosomes;crosslink;Crowding;Cytokinesis;daughter cell;Devices;Disease;Drug resistance;Engineering;Environment;Event;experimental study;extracellular;Fiber;fluorescence imaging;Fluorescence Recovery After Photobleaching;Fracture;Future;Genetic Materials;Genome;Health;Human;Image;improved;In Vitro;in vivo;Individual;insight;Invaded;Kinetics;Lead;Long-nosed rat-kangaroo;Malignant Neoplasms;Mammalian Cell;MCF10A cells;MDA MB 231;Measures;mechanical force;mechanical properties;Mechanics;Metaphase;Microtubule Bundle;Microtubules;migration;Mitosis;Molecular;Motor;Needles;Neoplasm Metastasis;novel therapeutics;Oncogenes;Oncogenic;Outcome;overexpression;physical property;pressure;Process;Proliferating;Protein Dynamics;Proteins;reconstitution;Reproducibility;response;segregation;Shapes;Sister Chromatid;Slide;Small Interfering RNA;stem;Structure;Testing;therapeutic development;Time;Tubulin;tumor;Work

PROJECT_TITLE: Defining the Mechanistic Impact of PRC1 Overexpression on Mammalian Spindle Mechanics

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F05-D (21)]


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Neurosciences;Nutrition;Obesity

ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: PROJECT NARRATIVE Obesity is an important health concern. This project builds on our expertise and established collaborations to learn how a process involved in embryonic development also plays a critical role in adult energy homeostasis. Better understanding of feeding behavior and energy homeostasis will lead to better treatments for human obesity.

PI_NAMEs: BERBARI, NICOLAS F (contact);REITER, JEREMY F

PROGRAM_OFFICER_NAME: COOKE, BRAD

PROJECT_TERMS: Acute;Adult;Affect;Alleles;appendage;Attenuated;Binding Proteins;Body Composition;Brain;Cell Signaling Process;cell type;Cells;Cilia;ciliopathy;Clinical;Collaborations;Communication;Cyclic AMP;Cyclic AMP-Dependent Protein Kinases;Development;Diabetes Mellitus;diet-induced obesity;Electrophysiology (science);Embryonic Development;Endocrine;Erinaceidae;experimental study;Fasting;feeding;Feeding behaviors;G Protein-Coupled Receptor Signaling;G-Protein-Coupled Receptors;Genetic;Health;Health Care Costs;Heart Diseases;hedgehog signal transduction;Homeostasis;Hormones;Human;Hyperphagia;Hypothalamic structure;Immunofluorescence Immunologic;In Situ Hybridization;In Vitro;in vivo;insight;Learning;Leptin;Ligands;Maps;MCHR1 gene;Measures;Mediating;Mediator;Microtubules;morphogens;mortality;Mus;Neurons;neurotransmission;novel;Obesity;Organ;Organism;Output;Overweight;Pathway interactions;Pattern;Peripheral;pharmacologic;Play;prevent;Process;Reporter;Research;restraint;Role;Signal Transduction;smoothened signaling pathway;Source;Testing;Tissues;tool;United States

PROJECT_TITLE: How Hedgehog Contributes to Centrally Mediated Energy Homeostasis?

STUDY_SECTION: POMD

STUDY_SECTION_NAME: Pathophysiology of Obesity and Metabolic Disease Study Section[POMD]


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Colorectal Cancer;Dietary Supplements;Digestive Diseases;Genetics;Human Genome;Nutrition;Prevention

ORG_CITY: PHILADELPHIA

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE Studies of how distinct dietary inputs integrate to affect colorectal cancer metabolism and epigenetic regulation are limited. This project will contribute to our understanding of how metabolic pathways regulate the differentiation and function of CRC, as well as how manipulation of host genetics can augment or limit the efficacy of dietary interventions. Determining the interaction between dietary inputs in the context of host genetics has the potential to identify novel mechanisms to inform dietary interventions to prevent and combat CRC.

PI_NAMEs: SHARMA, PRATEEK  (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: Acceleration;Acetates;Acetyl Coenzyme A;Acyl Coenzyme A;Affect;Behavior;Binding Proteins;Butyrates;cancer cell;Cancer Etiology;Cancer Patient;cancer risk;Carbohydrates;carcinogenesis;Catabolism;Cell Culture Techniques;Cell Differentiation process;Cells;Cessation of life;Chemopreventive Agent;ChIP-seq;Coenzyme A Ligases;Colon;colon cancer cell line;Colon Carcinoma;Colorectal Adenoma;Colorectal Cancer;colorectal cancer prevention;colorectal cancer risk;combat;combinatorial;Consumption;Data;Diet;diet and cancer;dietary;Dietary Component;Dietary Fiber;Dietary Intervention;dietary manipulation;Differentiated Gene;Distal;Down-Regulation;Enzymes;Epigenetic Process;epigenetic regulation;Epithelium;Esterification;experimental study;Family;Family member;Fatty Acids;Fiber;Fructose;Gene Expression;Gene Expression Profile;Gene Expression Regulation;Gene Targeting;Genes;Genetic;genetic signature;Glycolysis;Growth;gut microbiota;Histone Acetylation;histone modification;Histones;Immunohistochemistry;In Vitro;in vivo;in vivo Model;Individual;inhibitor;insight;Intervention;intestinal tumorigenesis;Investigation;Label;Link;lipid biosynthesis;liquid chromatography mass spectrometry;Malignant neoplasm of gastrointestinal tract;Malignant Neoplasms;Measurement;Mediating;Mesenchymal;Meta-Analysis;Metabolic;Metabolic Pathway;Metabolism;microbial;microbial composition;microbiota;Modeling;Modification;mortality;mouse model;Mus;Neoplasm Metastasis;novel;Nuclear;Nutrient;Organoids;Pathway interactions;Patient Care;Patients;Physiology;Positioning Attribute;Predisposition;prevent;Propionates;Prospective Studies;Proteomics;Regulation;Regulatory Element;response;Response Elements;Risk;Role;sex;Site;Stains;Sterols;Supplementation;Testing;The Cancer Genome Atlas;Tissues;transcription factor;transcriptome sequencing;tumor;Tumor Burden;tumor growth;tumor metabolism;tumor progression;tumorigenesis;Up-Regulation;Volatile Fatty Acids;Western Blotting;western diet;Work

PROJECT_TITLE: Investigating the Role of Diet and ACSS2 in Metabolic and Epigenetic Regulation of Colorectal Cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F09A-R (20)]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Immunotherapy;Infectious Diseases

ORG_CITY: MINNEAPOLIS

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE: PUBLIC HEALTH RELEVANCE Traditional SPF mouse models do not accurately reflect the immune compartment makeup observed in humans, particularly the T cell compartment. This proposal utilizes pet store mouse cohousing to normalize mouse pathogen exposure with the goal to explore the maintenance and function of long-lived effector CD8 T cells. These studies will help better understand the factors that promote T cell maintenance and function in a model with normal levels of pathogen exposure.

PI_NAMEs: LUCAS, ERIN D (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Address;Adoptive Cell Transfers;Adult;Bioinformatics;Biological Assay;Birth;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Compartmentation;Cell Culture Techniques;Cell Maintenance;Cell Physiology;Cells;Cellular biology;Chronic;Circulation;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;CRISPR/Cas technology;cytokine;Cytokine Receptors;cytotoxicity;Data;Effector Cell;Ensure;Environment;experience;experimental study;Exposure to;Flow Cytometry;Focal Infection;Genetic;germ free condition;Goals;Granzyme;Homeostasis;Human;Immune;Immune system;Immunization;Immunologics;Immunology;improved;in vivo;infancy;Infection;Inflammation;Inflammatory;insight;Institution;interest;Interleukin-12;Interleukin-2;Knock-out;Knowledge;Lead;Listeria;Longevity;Maintenance;Mature T-Lymphocyte;Measures;Mediating;Memory;microbial;Microscopy;Minnesota;Modeling;Modification;Monitor;mouse model;Mus;neonate;novel;pathogen;pathogen exposure;Pathway interactions;Pattern;Phase;Phenotype;Population;post-doctoral training;Postdoctoral Fellow;Production;public health relevance;receptor;Reporter;Research;Research Personnel;Resistance;response;Running;Scientist;Serum;skills;Sorting;Systemic infection;T cell therapy;T memory cell;T-Lymphocyte;Testing;Time;trafficking;Training;transcriptome sequencing;translational potential;Universities;vaccine development;Virus Diseases;Work

PROJECT_TITLE: Determining factors of inflammation that support the expansion and function of long-lived effector cell CD8 T cells in a mature memory compartment

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F07C-Y (20)]


NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: BOSTON

ORG_NAME: DANA-FARBER CANCER INST

ORG_STATE: MA

PHR: Project Narrative: Novel Ewing sarcoma therapies are urgently needed as children who present with metastatic disease have only a 30% chance of survival, and if a child relapses the chance of survival drops to nearly zero. This project aims to validate IGF2BP1 as a dependency in Ewing sarcoma, uncover the role IGF2BP1 plays in Ewing sarcoma pathogenesis, and biochemically characterize how IGF2BP1 promotes Ewing sarcoma growth. Through understanding how IGF2BP1 binds substrates, high-throughput chemical screens can be developed to identify novel, IGF2BP1 targeting molecules as future Ewing sarcoma therapeutics.

PI_NAMEs: BOND, MICHAEL JOSEPH (contact)

PROGRAM_OFFICER_NAME: ELJANNE, MARIAM

PROJECT_TERMS: 3' Untranslated Regions;Acute;Adenosine;Affect;Anchorage-Independent Growth;Attenuated;Binding;Biochemical;Biological Assay;Biology;bone;cancer cell;career;Cell Cycle;Cell Death;cell growth;Cell Line;Cell Survival;cell transformation;Cells;Chemicals;Chemotherapy-Oncologic Procedure;Child;Childhood;Childhood Solid Neoplasm;Chimeric Proteins;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;CRISPR/Cas technology;crosslinking and immunoprecipitation sequencing;Data;data mining;Databases;Dependence;design;Disease;Disease remission;DNA;Drops;Drug Combinations;Enzymes;Event;Ewings sarcoma;Fellowship;FLI1 gene;functional genomics;Future;Genes;Genetic;genome editing;graduate school;Growth;Guide RNA;Immunoprecipitation;In Vitro;in vivo;Infection;inhibitor;Injections;insight;Invaded;KH Domain;Knock-out;Libraries;Life Expectancy;Link;Maintenance;Malignant Bone Neoplasm;Malignant Childhood Neoplasm;Malignant Neoplasms;Maps;Mediating;Messenger RNA;Metastatic Ewing's Sarcoma;Methods;Mining;Modification;Molecular;Monitor;mRNA Transcript Degradation;Mus;Nature;new therapeutic target;novel;Oncogenes;Operative Surgical Procedures;Pathogenesis;patient derived xenograft model;Patients;Pharmaceutical Preparations;Phenotype;Play;Positioning Attribute;post-doctoral training;Proliferating;Proteins;Radiation therapy;Recurrence;Relapse;Repression;Research;Resistance;Resources;RNA;RNA-Binding Proteins;Role;skills;Small Interfering RNA;small molecule inhibitor;Standardization;Structure;Substrate Interaction;System;Testing;Therapeutic;therapeutic development;therapeutic target;tool;Training;Transcript;transcription factor;transcriptome sequencing;tumor;Tumor Burden;tumorigenic;Western Blotting;Work;Xenograft Model

PROJECT_TITLE: Investigating  IGF2BP1 as a novel Therapeutic Target for Ewing Sarcoma


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Congenital Structural Anomalies;Genetics;Pediatric;Prevention;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

PHR: PROJECT NARRATIVE Each year, approximately 240,000 infants die globally due to birth defects; although efforts have been made to address this through interventions and preventative strategies, progress is hindered by the challenges of understanding the genetic underpinnings of human development. In this proposal, we aim to investigate a novel epigenetic regulatory mechanism essential for hematopoietic development. The outcomes of this research are expected to significantly enhance our understanding of human development, potentially opening doors to innovative therapeutic approaches for combating birth defects and blood disorders.

PI_NAMEs: ABRAHAM, ELIZABETH  (contact)

PROGRAM_OFFICER_NAME: MUKHOPADHYAY, MAHUA

PROJECT_TERMS: Address;Affect;Anterior;Area;ATAC-seq;Biological Assay;Blood;Blood Cells;career;Catalytic Domain;Cell Culture Techniques;Cell Differentiation process;Cell Fate Control;cell growth;Cell Proliferation;cell type;Cells;Chromatin;chromatin protein;combat;comparison control;Complex;conditional knockout;Congenital Abnormality;Data;Defect;Development;Diagnosis;Disease;Doctor of Philosophy;Ectoderm;Embryo;Embryology;Embryonic Development;Endoderm;Enhancers;Epiblast;Epigenetic Process;Exhibits;experimental study;Eye Development;Fellowship;Fetal Development;Flow Cytometry;gastrulation;Gene Activation;Gene Expression;Genes;Genetic;Genetic Markers;Genetic Transcription;Goals;Hematological Disease;Hematopoietic;Hematopoietic stem cells;histone methyltransferase;Homologous Gene;Human Development;human embryonic development;human embryonic stem cell;in vivo;Infant;Infant Mortality;innovation;Innovative Therapy;insight;Intervention;Knowledge;Label;Literature;liver development;LoxP-flanked allele;Mediating;Mesoderm;Mesoderm Cell;Molecular Analysis;Molecular Target;Mus;next generation sequencing;novel;Nuclear Extract;Organ;organ growth;Organogenesis;Outcomes Research;Output;Paraxial Mesoderm;Pathway interactions;Pattern;Phenotype;Polycomb;Population;precursor cell;Prevention;Prevention strategy;Primitive Streaks;Proteins;Publications;Publishing;recruit;Regulation;Repression;Repressor Proteins;Resolution;Rest;restoration;RNA;Role;Signal Pathway;Signal Transduction;single-cell RNA sequencing;skills;SOX18 gene;Specific qualifier value;stem cell differentiation;Testing;Therapeutic;Tissues;tool;Training;Transcription Repressor;United States;Vascular Diseases;WNT3 gene;Work

PROJECT_TITLE: Investigating the role of YAP1 in blood cell specification


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: WASHINGTON

ORG_DEPT: MISCELLANEOUS

ORG_NAME: GEORGETOWN UNIVERSITY

ORG_STATE: DC

PHR: PROJECT NARRATIVE Medulloblastoma metastasizes outside of the brain leading to a ten-fold increase in mortality but the underlying mechanisms that lead to invasion and migration properties in medulloblastoma is still unknown. Our preliminary analyses indicate BAIAP2 and CDC42 have oncogenic roles leading to migratory properties in medulloblastoma. We will investigate their interaction in medulloblastoma in order to identify possible novel therapies.

PI_NAMEs: RUIZ, LUZ CLARITA (contact)

PROGRAM_OFFICER_NAME: ADAMS, GREGORY

PROJECT_TERMS: Actins;Affinity;angiogenesis;Binding;Biological Assay;Blood Circulation;Brain;brain cell;CDC42 gene;cdc42 GTP-Binding Protein;cell motility;Cell Proliferation;cell type;Cells;Cerebrospinal Fluid;chemotherapy;Chemotherapy and/or radiation;Child;Childhood Malignant Brain Tumor;Chromium;Clinical;Cognitive;Data;Data Set;differential expression;Distant;Doxycycline;effective therapy;Excision;experimental study;Face;Foundations;Functional disorder;Future;gene discovery;Genes;Genetic Engineering;Genomics;high risk;Histology;Implant;improved;In Vitro;in vivo;Individual;innovation;Invaded;Kinetics;knock-down;Knowledge;Literature;Magnetic Resonance Imaging;Malignant neoplasm of brain;Measures;Mediating;Medical;Medulloblastoma;Methods;migration;Modeling;mortality;Mus;Neoplasm Metastasis;Neurodevelopmental Disorder;NOD/SCID mouse;novel;novel therapeutics;Oncogenic;Operative Surgical Procedures;Organoids;Outcome;particle;Pathogenesis;Patients;pediatric patients;polymerization;Polymers;Process;Prognosis;Prognostic Marker;Proliferating;Property;protein protein interaction;Proteins;Publishing;Research;Role;screening;SHH gene;side effect;single-cell RNA sequencing;Site;small hairpin RNA;Small Interfering RNA;Specificity;spheroids;Stains;Subgroup;Surface Plasmon Resonance;Survivors;Testing;Therapeutic;therapeutic target;Time;treatment strategy;Treatment-related toxicity;tumor;tumor growth;Validation;Work

PROJECT_TITLE: Identification of BAIAP2 and CDC42 as potential therapeutic targets in SHH medulloblastoma

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F09B-Z (20)]


ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE: Antibiotics are primary treatments for bacterial infections, but their use promotes generation of multi- resistant pathogens, affects the diversity and function of the microbiota, and subsequently impacts the intestinal regulatory immune system. Very little is known about how commonly prescribed oral antibiotics, such as ciprofloxacin, impacts beneficial gut microbes, such as Lactobacillus, and its interaction with the host immune system. This project addresses that gap by investigating how the ciprofloxacin-selected Lactobacillus alters the function of intestinal regulatory lymphocytes.

PI_NAMEs: RIVERA-RODRIGUEZ, DORMARIE  (contact)

PROGRAM_OFFICER_NAME: MOITRA, KAROBI

PROJECT_TERMS: 16S ribosomal RNA sequencing;Address;Affect;Anaerobic Bacteria;Anti-Inflammatory Agents;Antibiotic susceptibility;Antibiotic Therapy;Antibiotics;Bacterial DNA;Bacterial Infections;beneficial microorganism;Biological Assay;Cells;Ciprofloxacin;Citrobacter rodentium;Colitis;Colon;Colony-forming units;commensal bacteria;cytokine;Data;Development;Diet;DNA biosynthesis;dysbiosis;effective therapy;Environment;experimental study;Flow Cytometry;Fluoroquinolones;FOXP3 gene;gastrointestinal function;gastrointestinal infection;Gastrointestinal tract structure;Generations;gut colonization;gut microbes;host microbiome;ileum;Immune;Immune response;Immune system;immunoregulation;In Vitro;in vivo;Infection;Infection prevention;Inflammation;insight;Interleukin-10;Intestines;intraepithelial;Knowledge;Lactobacillus;Lamina Propria;Large Intestine;Lymphocyte;macromolecule;Macrophage;Mediating;Medicine;Methods;microbial;microbiota;Mucous Membrane;multi-drug resistant pathogen;Mus;Nutrient;opportunistic pathogen;Oral;pathogen;Phenotype;Population;Population Analysis;Population Dynamics;Prevalence;Production;Regulatory T-Lymphocyte;Reporter;Resistance;response;Role;Small Intestines;Stimulus;Structure;T-Lymphocyte;Techniques;Testing;uptake;Work

PROJECT_TITLE: Impact of antibiotic treatment on Lactobacillus population dynamics and intestinal T cell regulatory function

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F07A-B (20)]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: IOWA CITY

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Project Narrative Alzheimer’s Disease and its related dementias (ADRD) have become both a health and financial crisis in America; it is currently estimated that one-third of seniors dies with ADRD, and more than 11 million Americans provide unpaid care for persons with ADRD. There are currently no viable treatments for ADRD that have been shown to rescue brain function. My proposal will contribute fundamental knowledge to early ADRD reversal, using an interventional approach that may someday achieve clinical relevance in the treatment of ADRD.

PI_NAMEs: KOLLING, LOUIS  (contact)

PROGRAM_OFFICER_NAME: SARE, RACHEL

PROJECT_TERMS: 3-Dimensional;Affect;Age;Age Months;Alzheimer's Disease;American;Amyloid beta-Protein;Area;Axonal Transport;Behavior;Behavioral;Binding;Brain;Brain region;Caring;Cell Physiology;Cerebrum;clinically relevant;Cytoskeleton;Data;Dementia;Deposition;depressive symptoms;Digestion;Disease Progression;Dissociation;DNA;dorsal raphe nucleus;Electrophysiology (science);entorhinal cortex;Excision;Exhibits;Fellowship;Functional disorder;Health;Hippocampus;hTau Mice;Human;Image;Impaired cognition;In Vitro;Intervention;intervention effect;Iowa;Knowledge;Laboratories;Light;Literature;MAPT gene;Mediating;Microtubule-Associated Proteins;Microtubules;mouse model;Mus;Nerve Degeneration;Neurofibrillary Tangles;neuron loss;neuronal survival;Neurons;Neurosciences;paired helical filament;Pathology;Pathway interactions;Peptide Hydrolases;Persons;Pharmacology;Phenotype;Phosphorylation;Phosphotransferases;Predisposition;Protein Dephosphorylation;Protein Isoforms;Protein phosphatase;Protein Phosphatase 2A Regulatory Subunit PR53;Proteins;Psychological reinforcement;raphe nuclei;research and development;Research Training;Resistance;Retrograde Degeneration;Serotonin;Sleep;Sleep disturbances;Sleeplessness;Social Interaction;Synapses;tau aggregation;tau dysfunction;tau expression;tau Proteins;tau-1;Testing;Therapeutic Intervention;Time;Training;Treatment outcome;Ubiquitination;Universities;vector induced;Viral;Viral Vector

PROJECT_TITLE: Reversal of Tau Pathology to Rescue Serotonergic Function in Early Alzheimer’s Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F03C-K (20)]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Genetics

ORG_CITY: CHAPEL HILL

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE Diseased skeletal muscles exhibit abnormal patterns of RNA processing. The proposed work aims to determine how disruption to the RNA processing of the clathrin gene products leads to defects in skeletal muscle function. By defining these cellular and molecular events, the proposed studies will help identify targets that can be used to develop novel therapeutics to treat skeletal muscle diseases.

PI_NAMEs: COTE, JESSICA LEIGH (contact)

PROGRAM_OFFICER_NAME: VINCENT, ISAAH S

PROJECT_TERMS: Actins;Adult;Alternative Splicing;Antisense Oligonucleotides;Architecture;Binding;Biogenesis;Cell Culture Techniques;Cell membrane;Cell Physiology;cell type;Cells;Cellular biology;Clathrin;Clathrin Heavy Chains;Confocal Microscopy;Core Facility;CRISPR/Cas technology;Cytoskeleton;Data;Defect;Development;Disease;Down-Regulation;Dynamin 2;Early Endosome;effective therapy;Endocytosis;Endosomes;Environment;Equilibrium;Event;Exhibits;Exons;fetal;Fiber;Foundations;gene product;Generations;Genes;Goals;Group Meetings;Health;hepatocyte growth factor-regulated tyrosine kinase substrate;Image Analysis;Immunohistochemistry;In Situ;In Situ Hybridization;In Vitro;insight;Institution;Ion Channel;Lead;Measures;Mediating;Membrane;Molecular;Molecular Cloning;monomer;mouse model;Mus;Muscle;Muscle Cells;Muscle Contraction;Muscle Development;Muscle Fibers;Muscle function;Muscle Weakness;Myopathy;Myotonic dystrophy type 1;Neonatal;North Carolina;novel;novel therapeutics;Nucleotides;Pathogenesis;Pathology;Patients;Pattern;Play;postnatal;postnatal development;posttranscriptional;prevent;Productivity;programs;Protein Biosynthesis;protein degradation;Protein Isoforms;Protein Sortings;Proteins;receptor;Research;Research Personnel;RNA Processing;RNA Splicing;Role;scaffold;Scaffolding Protein;skeletal disorder;Skeletal Muscle;skeletal muscle weakness;skills;Soleus Muscle;Sorting;Specificity;Striated Muscles;Structure;targeted treatment;Testing;tibialis anterior muscle;timeline;trafficking;Training;Ubiquitin;Universities;Work

PROJECT_TITLE: Clathrin alternative splicing in skeletal muscle development

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F10B-Q (20)]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE The vestibular inner ear encodes head motions through the displacement of mechanosensitive hair bundles and distinct afferent firing patterns. Previous work has characterized hair cell and afferent properties at the single- cell level yet how head motions are encoded at the circuit-level is not well understood. The objective of the proposed study is to use hair cell and afferent voltage-gated ion channels as building blocks for circuit-level computational models that are more faithful to how the system encodes head motions.

PI_NAMEs: LUTZ, OLIVIA  (contact)

PROGRAM_OFFICER_NAME: SCHURMAN, JACLYN REBECCA

PROJECT_TERMS: Address;Bayesian Analysis;Biological;biophysical properties;Brain Stem;Calcium;Cells;Code;Computer Models;computer studies;dimension reduction;Dimensions;Epithelium;Equation;Feedback;Hair;Hair Cells;Head;Hodgkin-Huxley model;Image;insight;Ion Channel Gating;Knowledge;Laboratories;Measurement;Mechanics;Mediating;Modeling;Molecular;Morphology;Motion;neural;neural model;neural network;Neurons;open source;Pattern;Performance;Peripheral;Physiological;Population;Potassium;Presynaptic Terminals;Property;receptive field;response;Response to stimulus physiology;Rest;spatiotemporal;statistics;Stimulus;Structure;Synapses;Synaptic Transmission;System;Techniques;Time;two-dimensional;two-photon;vector;Vestibular epithelia;Vestibular function;Vestibular inner ear;vestibular system;voltage;With laterality;Work

PROJECT_TITLE: Spatiotemporal models of neural coding in the vestibular periphery

STUDY_SECTION_NAME: Special Emphasis Panel[ZDC1 SRB-Y (58)]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Infectious Diseases

PHR: Narrative: Periodontitis is a chronic inflammatory disease that leads to the destruction of the tooth-supporting structures including periodontal tissue attachment and alveolar bone. We propose that activation of a newly identified cell surface receptor present on gingival mast cells contributes to inflammation and periodontal bone loss. Development of novel humanized mouse models to study how this receptor is activated may provide new approaches to modulate periodontitis.

PI_NAMEs: ALI, HYDAR  (contact);SAHINGUR, SINEM ESRA

PROGRAM_OFFICER_NAME: CHANDER, PREETHI

PROJECT_TERMS: Actins;Adaptor Signaling Protein;Agonist;alveolar bone;Alveolar Bone Loss;antagonist;antimicrobial;Attenuated;beta-arrestin;Binding;Biology;bone loss;Bone Marrow;Bone Marrow Stem Cell;cathelicidin;cathelicidin antimicrobial peptide;Cell Surface Receptors;Cells;Chemotaxis;chronic inflammatory disease;Code;cofilin;Coupled;CRISPR/Cas technology;cytokine;Data;Defensins;depolymerization;desensitization;Development;Disease;Engraftment;Environment;Epithelium;G protein coupled receptor kinase;G-Protein-Coupled Receptors;gastrointestinal;Generations;Gingiva;Gingivitis;GTP-Binding Proteins;Homeostasis;Host Defense;host-microbe interactions;Human;humanized mouse;Immune;Inflammation;Inflammatory;intraperitoneal;Lesion;Ligature;mast cell;Mediating;Mediator;Modeling;Mononuclear;mouse model;Mucous Membrane;Mus;neutrophil;novel;novel strategies;Oral;Orthologous Gene;Osteitis;Pathway interactions;Patients;Peptides;Periodontal Diseases;Periodontitis;Periodontium;Phosphorylation;Phosphorylation Site;Porphyromonas gingivalis;Pre-Clinical Model;Protein Dephosphorylation;quorum sensing;receptor;Receptor Cell;recruit;Regulation;Respiratory System;retroviral transduction;Role;Rosacea;Saliva;Sequence Homology;Severity of illness;Signal Transduction;Skin;small molecule;Testing;Tissues;Wild Type Mouse

PROJECT_TITLE: Role of a novel G protein-coupled mast cell receptor-mediated pathways in periodontal disease

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]


ORG_CITY: ANN ARBOR

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE The dysregulation of inflammation and immune responses plays a key role in the pathophysiology of skin disorders, including psoriasis, atopic dermatitis, hidradenitis suppurativa, and pachyonychia congenita. This project is focused on identifying keratin-dependent pathways in epidermal keratinocytes and understanding their role in regulating the spatiotemporal pattern of neutrophil infiltration and engagement of other cellular effectors in inflamed skin. Completion of the proposed studies will generate new insight into skin homeostasis and may help identify new biomarkers and new targets for the diagnosis and treatment of skin disorders.

PI_NAMEs: COULOMBE, PIERRE  (contact);PARENT, CAROLE ANNE

PROGRAM_OFFICER_NAME: UNDALE, ANITA H

PROJECT_TERMS: Aggressive behavior;Animals;Atopic Dermatitis;Binding;Biochemical;biological adaptation to stress;Biological Markers;Biology;biomarker identification;Cell Culture Techniques;cellular targeting;chemokine;Chronic;chronic inflammatory skin;CXCL1 gene;CXCL2 gene;Data;defined contribution;Dermis;Diagnosis;Disease;Ensure;Epidermis;Event;Exposure to;Functional disorder;Head;Hidradenitis Suppurativa;Homeostasis;Human;immune cell infiltrate;Immune response;in vivo;Individual;Inflammation;Inflammatory;inflammatory modulation;Inflammatory Response;Innate Immune Response;insight;Intermediate Filaments;Irritants;Keratin;keratinocyte;Knockout Mice;Link;Macrophage;Maps;Mediating;Modeling;Mus;Natural Immunity;neutrophil;Neutrophil Infiltration;novel;pachyonychia congenita;Parents;Pathway interactions;Pattern;Play;PRKCA gene;Property;Proteins;Psoriasis;Regulation;Research Personnel;response;Role;Signal Transduction;single cell analysis;Skin;skin disorder;Skin Tissue;spatiotemporal;Sterility;Stress;stressor;Structure;Testing;transcriptomics;Transgenic Mice

PROJECT_TITLE: Keratinocyte-dependent regulation of innate immune responses in inflamed skin

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MSOS-H (02)]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: MADISON

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE Precise regulation of neutrophil inflammatory state following myocardial infarction is critical in driving cardiac repair. The balance of chemical and mechanical cues that regulate this state, and the mechanisms by which they act, remain poorly understood. This proposed research will contribute to human health by elucidating mechanisms by which neutrophils integrate chemical and mechanical cues to regulate inflammatory state, which will inform the design of therapeutics to modulate this process in the context of human cardiovascular disease.

PI_NAMEs: SCHROPE, JON  (contact)

PROGRAM_OFFICER_NAME: MEADOWS, TAWANNA

PROJECT_TERMS: Acute;Anti-Inflammatory Agents;Automobile Driving;Biological Models;Cardiac;Cardiac Myocytes;cardiac regeneration;cardiac repair;Cardiovascular Diseases;Cardiovascular system;career;Cells;Cellular biology;Cessation of life;Chemicals;Clinical;clinically significant;Communication;Confined Spaces;Coupled;Cues;cytokine;design;Development;Dissection;Engineering;Environment;Equilibrium;Event;experience;experimental study;Failure;Fellowship;Future;genetic manipulation;Goals;Growth Factor;healing;Health;Heart failure;Heart Injuries;Human;human induced pluripotent stem cells;Immune;Immune response;Immune system;improved;In Vitro;in vivo;in vivo imaging;induced pluripotent stem cell;Infarction;Inflammatory;Injury;injury and repair;innovation;interdisciplinary approach;interstitial;Knowledge;Leukocytes;Liquid substance;mechanical force;mechanical pressure;mechanical signal;Mechanical Stress;Mechanics;Mediating;Medical;Mentorship;Microfluidics;migration;Modeling;Motility;Mus;Myelogenous;Myocardial Infarction;Natural regeneration;neutrophil;Neutrophil Activation;Neutrophil Infiltration;Paracrine Communication;Phenotype;Physicians;Piezo 1 ion channel;Play;Positioning Attribute;pre-doctoral;Process;Production;Protein Secretion;Publishing;Reactive Oxygen Species;Recovery;Recurrence;regeneration model;Regulation;Research;research and development;Resources;response;Risk;Role;Scientist;Seminal;Signal Pathway;Signal Transduction;Site;skills;Sterility;Stroke;stroke risk;Survivors;System;targeted treatment;Technology;Testing;Therapeutic;therapeutic target;tissue injury;tissue repair;Tissues;tool;Training;United States;Universities;Wisconsin;Work;wound healing;Wound models;Zebrafish

PROJECT_TITLE: Investigating the role of myeloid-derived growth factor in opposing neutrophil mechanical activation to regulate cardiac healing in the context of myocardial infarction


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: Nashville

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: Project Narrative We propose the development of a 3D hydrogel platform that can anchor soluble bioinert ligands, like GFP, for the activation of regenerative cell behaviors from cells engineered with synthetic Notch receptors. We hypothesize that this innovative technology will lead to tunable and dynamic control of cellular behaviors with high levels of spatial control from the captured ligands. To demonstrate the therapeutic potential of our platform, we will test inflammation attenuation and differentiation of multipotent cells to osteogenic and chondrogenic fates for musculoskeletal repair.

PI_NAMEs: LEE, JOANNE  (contact)

PROGRAM_OFFICER_NAME: GUTEKUNST, DAVID JOSEPH

PROJECT_TERMS: 3-Dimensional;Address;Aging;Alkaline Phosphatase;antagonist;Anti-Inflammatory Agents;Area;Attenuated;attenuation;Autoimmune Diseases;Bathing;Behavior;Biochemical;Biocompatible Materials;Biological Assay;Biological Factors;biomechanical test;bioscaffold;career;career development;cell behavior;Cell Differentiation process;Cell Proliferation;Cell surface;Cell Survival;Cell Therapy;cell type;Cells;cellular engineering;Coculture Techniques;Cues;cytokine;design;Development;Diabetes Mellitus;Disease;Educational Status;Elements;Encapsulated;Engineering;Environment;Enzyme-Linked Immunosorbent Assay;Exposure to;Extracellular Domain;Extracellular Matrix;Fellowship;Fibroblasts;Flow Cytometry;Formulation;Foundations;Gel;Genes;Genetic Transcription;Goals;Growth Factor;Histology;Hydrogels;Immune;Immunohistochemistry;implantation;in vivo;Inflammation;Inflammatory;inflammatory milieu;Injury;innovation;innovative technologies;insulin secretion;Ligands;luminescence;Malignant Neoplasms;Mediating;Mentors;mesenchymal stromal cell;Methods;migration;multidisciplinary;multipotent cell;Mus;Muscle Fibers;Musculoskeletal;nanobodies;Natural regeneration;new technology;notch protein;Notch Signaling Pathway;osteochondral tissue;osteogenic;Output;Pathway interactions;Polyethylene Glycols;Population;Preparation;Production;programs;Proliferating;Proteins;receptor;Receptor Signaling;regeneration function;regenerative;regenerative cell;Regenerative Medicine;Regenerative response;regenerative tissue;repaired;Reporter;Research;response;scaffold;Scientist;side effect;Signal Pathway;Signal Transduction;stem cells;Supporting Cell;synthetic biology;Techniques;Technology;Testing;Therapeutic;Time;time use;Tissue Engineering;tissue regeneration;Tissues;TNF gene;tool;Training;transcription factor;Transgenes;Validation;Work;wound healing

PROJECT_TITLE: Co-engineering Synthetically Programmed Cells and Biomaterials for Regenerative Medicine

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F05-Q (20)]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology

PHR: Project narrative Biological energy transduction is crucial to life and is primarily orchestrated through the coupling of proton and electron movement. While electron transfer has been extensively studied, proton transfer has been more difficult to study experimentally. Through protein design, we will design and express proteins that bind abiological photoacid cofactors that will enable us to observe, for the first time, the generation and management of proton currents in proteins, giving fundamental insight into proton conduction in biological systems and take the first step toward the design of complex protein machinery.

PI_NAMEs: BAKANAS, IAN  (contact)

PROGRAM_OFFICER_NAME: JONES, LATAISIA CHERIE

PROJECT_TERMS: 2019-nCoV;absorption;Acidity;Affinity;Amino Acid Sequence;Area;Back;Bacteria;Binding;Binding Proteins;Binding Sites;Biological;Biological Process;biological systems;career;Cells;Charge;Chemicals;cofactor;Collaborations;Complication;computerized tools;Coupled;Coupling;deprotonation;design;Device Designs;drug discovery;Dyes;Electron Transport;Electrons;Engineering;Enzymes;experimental study;Generations;generative models;Goals;Harvest;High Prevalence;Hydrogen Bonding;influenzavirus;innovation;insight;irradiation;Kinetics;Life;Light;Measurable;Membrane;Metals;Methodology;Methods;migration;Monitor;Movement;Nature;Network-based;neural network;NMR Spectroscopy;novel strategies;Organelles;Organic Synthesis;Oxidation-Reduction;Pathway interactions;Pharmaceutical Preparations;Photosynthesis;Porphyrins;Positioning Attribute;Postdoctoral Fellow;Process;Property;protein complex;Protein Engineering;protein expression;protein folding;Proteins;protonation;Protons;Pump;rational design;Reaction;Recording of previous events;Reproduction;Research;Rhodopsin;Sampling;Scaffolding Protein;Signal Transduction;skills;small molecule;Solvents;spectroscopic survey;Spectrum Analysis;Structure;success;System;Testing;Therapeutic;Time;tool;Training;Universities;Viral;Water;X-Ray Crystallography

PROJECT_TITLE: De novo design of photoacid-binding proteins to study proton dynamics in biological systems

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F04-S (20)]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Drug Abuse (NIDA only);Mental Health;Mental Illness;Neurosciences;Substance Misuse

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: PROJECT NARRATIVE To navigate our complex and dynamic world, humans must use information obtained from past experiences and environmental/social cues to guide their decisions. This critical cognitive function is compromised in patients with autism spectrum disorders and obsessive-compulsive disorder. This study aims to advance our understanding of the neural basis of context-dependent, flexible decision making which may lead to the prevention and treatment of these mental illnesses.

PI_NAMEs: SHEN, JIA  (contact)

PROGRAM_OFFICER_NAME: LIN, YU

PROJECT_TERMS: 3-Dimensional;Address;Animal Model;Animals;Anterior;Apical;Area;Attention deficit hyperactivity disorder;autism spectrum disorder;Behavior;Behavioral;Behavioral Paradigm;behavioral response;Brain;Brain region;cingulate cortex;Cognitive;cognitive control;cognitive function;Collaborations;Complex;Computer Models;Cues;Data;Decision Making;Dendrites;Disease;Environment;executive function;Exhibits;experience;experimental study;flexibility;frontal lobe;Genetic;Goals;hippocampal pyramidal neuron;Holography;Human;Image;Imaging Device;Impairment;information processing;insight;Interneurons;Knowledge;Lateral;Left;Maps;Mediating;Mental disorders;Methods;Modality;Molecular;Motor Cortex;mouse model;Movement;Mus;National Institute of Mental Health;Nervous System Disorder;neural;neuroimaging;neuromechanism;Neurons;Obsessive-Compulsive Disorder;Odors;Olfactory Pathways;Optics;optogenetics;Pathway interactions;Patients;Pattern;Perception;Performance;Prefrontal Cortex;Prevalence;Prevention;Process;Quality of life;repetitive behavior;response;Role;Route;Sampling;Sensory;sensory stimulus;Series;Side;Signal Transduction;social;Stimulus;success;Testing;Travel;two-photon;Update;Work

PROJECT_TITLE: Unraveling the neural mechanism underlying context-dependent decision making

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F02B-Y (20)]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Genetics;Huntington's Disease;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: WORCESTER

ORG_DEPT: GENETICS

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: PROJECT NARRATIVE Huntington’s Disease – a devastating neurodegenerative condition – is caused by a defect in the Huntingtin gene, resulting in the production of alternative forms of Huntingtin mRNA and protein. This proposal will use small RNA drugs to reduce alternative forms of Huntingtin in mouse models of Huntington’s disease and determine the effect on disease features and outcomes. Findings from these studies will provide insight into the mechanisms underlying Huntington’s Disease to inform the development of future therapeutics.

PI_NAMEs: ALLEN, SARAH JANE (contact)

PROGRAM_OFFICER_NAME: MATTHEWS, MARGUERITE

PROJECT_TERMS: Affect;Alternative Splicing;autosome;Bacterial Artificial Chromosomes;Biology;Brain;Brain region;CAG repeat;Cell Nucleus;Cells;Central Nervous System;Chemicals;Clinical;Cognitive;Corpus striatum structure;Cytoplasm;Defect;Development;Disease;Disease Outcome;Disease Progression;Exhibits;Exons;experience;Feedback;Fluorescence;Fluorescent in Situ Hybridization;Future;Gene Silencing;Genes;Genetic Transcription;Harvest;Human;Huntington Disease;Huntington gene;Image;In Vitro;in vivo;Inherited;Injections;insight;knock-down;Lead;Length;Link;Measures;Mental Depression;Messenger RNA;Microscopy;Modification;Molecular;Motor;mouse model;mRNA Expression;Mus;mutant;Nerve Degeneration;Neurodegenerative Disorders;Neurons;nonhuman primate;Nuclear;Onset of illness;Outcome;Pathogenicity;Pathology;Patients;Pattern;Pharmaceutical Preparations;Predisposition;Prevalence;Process;Production;protein aggregation;protein expression;Protein Isoforms;Proteins;RNA;RNA Splicing;RNA-Binding Proteins;Role;scaffold;Site;Small Interfering RNA;Small RNA;Testing;Therapeutic;therapeutic development;therapeutic target;therapy design;Time;Training;Transcript;transcriptome sequencing;Translations;Treatment Failure;treatment strategy;Work

PROJECT_TITLE: Examining the Role of a Pathogenic HTT Isoform, HTT1a, in Somatic Expansion and RNA Aggregation in Huntington's Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F03A-E (20)]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Autoimmune Disease;Brain Disorders;Cardiovascular;Clinical Research;Disability Research;Multiple Sclerosis;Neurodegenerative;Neurosciences;Physical Activity;Prevention

ORG_CITY: Chicago

ORG_DEPT: NUTRITION

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: Project Narrative The ability for blood vessels to dilate for the delivery of oxygen (O2) to targeted muscles and the extraction of O2 at the muscle level are impaired in persons with multiple sclerosis (MS); however, no research has examined the influence of lower-limb vascular function on poor walking efficiency in this population. This project may identify specific vascular mechanisms that contribute to walking efficiency in persons with MS. Such findings may guide researchers, clinicians, and exercise specialists in the design of targeted approaches to improve walking efficiency and its consequences with the aim of promoting health, managing comorbidities, and enhancing overall well-being, quality of life, and participation in the community.

PI_NAMEs: JENG, BRENDA  (contact)

PROGRAM_OFFICER_NAME: MARDEN, SUSAN F

PROJECT_TERMS: Adult;Aerobic;Age;Area;Arteries;Blood flow;Blood Vessels;Body Weight;brachial artery;Cardiovascular Physiology;Cardiovascular system;Communities;Community Participation;comorbidity;Comparative Study;Consumption;cost;design;Development;Diagnosis;disability;Disability status;Disease;early onset;Educational Intervention;Exercise;exercise rehabilitation;exercise training;Fatigue;Forearm;Functional disorder;Future;Gait abnormality;Gastrocnemius Muscle;General Population;Health Promotion;Hypertension;Hypoxia;Impairment;improved;Intervention;Kilogram;Life;Lower Extremity;Measures;Metabolism;Methods;Mitochondria;Multiple Sclerosis;multiple sclerosis patient;Muscle;Muscle function;Neurologic;Outcome;Oxygen;peripheral blood;Personal Satisfaction;Persons;Physical activity;Physiological;Population;Quality of life;Research;Research Personnel;response;sex;Specialist;Structure of popliteal artery;Surface;Task Performances;Travel;Trees;United States;Upper Extremity;Vascular Diseases;Vascular remodeling;Vasodilator Agents;Walking

PROJECT_TITLE: Walking Inefficiency in Multiple Sclerosis: Influence of Vascular Dysfunction

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F16-H (20)]


ORG_CITY: Princeton

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: PRINCETON UNIVERSITY

ORG_STATE: NJ

PHR: PROJECT NARRATIVE The regulation of gene expression to produce proteins at the right time and right place is essential for animal development. Localization of messenger RNA (mRNA) and local translation is one method of regulating gene expression posttranscriptionally, and this mRNA regulation is necessary for establishing asymmetrical protein distributions to create the architecture of polarized cells during a process called morphogenesis. This proposal examines the localization and protein interactors of an mRNA as neurons remodel their axons and dendrites during morphogenesis using a relevant fruit fly (Drosophila) model through novel CRISPR/Cas13-based methods.

PI_NAMEs: MCMANUS, ELIZABETH  (contact)

PROJECT_TERMS: Actins;Amyotrophic Lateral Sclerosis;Animals;aptamer;Architecture;Atrophic;Axon;Behavior;Binding;Biological;Biology;Biotin;Biotinylation;Cell Nucleus;Cell Polarity;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;Complex;CRISPR/Cas technology;Defect;Dendrites;Development;Disease;Distal;Drosophila genus;Ensure;Event;Family;Fluorescent in Situ Hybridization;Foundations;Fragile X Syndrome;Gene Expression;Gene Expression Regulation;Goals;Green Fluorescent Proteins;Growth;Guide RNA;Human;Image;imaging system;interest;Knowledge;Label;Ligase;Link;Maintenance;Mammalian Cell;Mass Spectrum Analysis;Messenger RNA;meter;Methods;Modeling;Morphogenesis;Morphology;Motility;Motor;Mushroom Bodies;Mutation;Nature;Nervous System Disorder;Neurites;Neurons;novel;novel strategies;Nuclear Export;nuclease;Organism;Peripheral;Phase;polarized cell;Post-Transcriptional Regulation;posttranscriptional;Process;profilin;protein distribution;Proteins;Proteome;Regulation;Research;RNA;RNA Probes;RNA Splicing;RNA-Binding Proteins;Role;Sampling;Site;spatiotemporal;Spinal;Stereotyping;Structure;Study models;System;Techniques;Time;Transcript;Transcriptional Regulation;Translations

PROJECT_TITLE: Interrogating spatiotemporal control of mRNA in Drosophila morphogenesis using Cas13-based techniques


NIH_SPENDING_CATS: Aging;Cancer;Cancer Genomics;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Genetics;Human Genome;Pediatric;Pediatric Cancer;Rare Diseases

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: PROJECT NARRATIVE: Oral cancer is associated with extensive morbidity and mortality and limited treatment options. In this study, I will examine how two newly acknowledged hallmarks of cancer, cell plasticity and senescence, and one enabling characteristic, epigenetic remodeling, contribute to oral cancer evolution. The aim of this research is to better understand oral cancer biology and develop improved therapeutic options for patients.

PI_NAMEs: FISHER, EMILY  (contact)

PROGRAM_OFFICER_NAME: FUQUA, CHANTEL FAYSAN

PROJECT_TERMS: Acetylation;Address;Adopted;Age;age effect;age related;Aging;Anatomy;beta catenin;Cancer Biology;cancer stem cell;Cell Aging;Cell Cycle;Cell Cycle Arrest;cell growth;Cell Line;Cells;Characteristics;Chromatin;Chromatin Structure;Chronic;Cleavage Under Targets and Release Using Nuclease;cohort;Complex;CREBBP gene;Dasatinib;Dependence;Diagnosis;differential expression;Disease;Doxycycline;Early Diagnosis;effective therapy;Epigenetic Process;epigenomics;Epithelial Cells;Epithelium;Evolution;experimental study;Fluorescence;Gene Expression;Gene Expression Profile;Genes;Genetic Transcription;Genome;Head and Neck Cancer;Heterogeneity;histone methylation;histone methyltransferase;Histones;HPV negative;Human;Immunofluorescence Immunologic;Immunohistochemistry;Implant;improved;In Vitro;in vivo;inhibitor;insight;Isogenic transplantation;Knock-out;Knowledge;Laboratories;Lysine;malignant mouth neoplasm;Malignant Neoplasms;Maps;Mediating;Methylation;Methyltransferase;Mixed-Lineage Leukemia;MLL gene;Morbidity - disease rate;mortality;Mouse Cell Line;mouse model;mouth squamous cell carcinoma;Mus;Mutation;Neoplasm Metastasis;Nitroquinolines;novel;novel therapeutics;Nuclear;old mice;oral cavity epithelium;Oxides;Paracrine Communication;Patients;pharmacologic;Phenotype;Placebos;Process;programs;protein complex;protein expression;Proteins;Quercetin;recruit;Research;Research Project Grants;Resistance;senescence;senescence associated secretory phenotype;senescent cell;senolytics;Signal Pathway;Signal Transduction;Signaling Protein;single-cell RNA sequencing;small hairpin RNA;Testing;Therapeutic;Tobacco;Tongue;Tongue Neoplasms;Transcript;Transcription Initiation Site;Transfection;tumor;tumor growth;tumorigenesis

PROJECT_TITLE: Identifying novel contributors to Wnt/beta-catenin mediated epigenetic activity in the evolution of OSCC

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Contraception/Reproduction;Women's Health Research

PHR: Project Narrative The proposed research will provide insight into the relationship between chronic health conditions occurring early in the life course and fertility patterns, including the mechanisms through which these processes are connected. Results from this study will improve demographic knowledge of population fertility by enhancing understandings of fertility goals, timing, and achievement in the context of chronic health conditions, particularly as average maternal age at birth increases in the U.S. This project will provide an unparalleled opportunity to train the applicant in the methodological tools and professional skills required to complete the proposed research and develop into a social demographer poised to study this important intersection between health and fertility.

PI_NAMEs: CANNON, LINDSAY MARIE (contact)

PROGRAM_OFFICER_NAME: TAYMANS, SUSAN

PROJECT_TERMS: Achievement;Address;Adolescent;Adoption;Adult;Advocate;Affect;Age;aged;Assisted Reproductive Technology;Behavior;Birth;Cardiovascular Diseases;caregiving;child bearing;Childbirth;Chronic;Chronic Disease;Clinical;Clinical Management;Complex;Data;Data Analyses;Data Set;Decision Making;Demographer;Demography;Diabetes Mellitus;Dimensions;disability;Discipline of obstetrics;Disease;disease diagnosis;Disparate;Epidemiology;Family;Fertility;Foundations;Functional disorder;Future;Goals;Gynecology;Health;improved;Individual;Inequality;insight;intergenerational;Interview;Investigation;Justice;Kinship Networks;Knowledge;Least-Squares Analysis;Life Cycle Stages;life span;Link;Longitudinal Studies;Maternal Age;Medical;medical attention;Mental Health;Mentors;Methodology;Methods;Morbidity - disease rate;mortality;National Longitudinal Survey of Youth;Parents;Patient Self-Report;Patient-Centered Care;Patients;Pattern;Perception;perinatal health;Personal Satisfaction;Persons;Phase;Policies;Policy Maker;Population;Pregnancy;pregnancy health;pregnant;premature;Premature Mortality;Process;Professional Competence;Quality of life;Race;racial difference;Recommendation;reproductive;Research;Research Personnel;Resources;Risk;Running;Sampling;satisfaction;Senior Scientist;Sequence Analysis;sex;Shapes;skills;social;social factors;Structure;Testing;Time;tool;Traction;Training;transmission process;Unipolar Depression;United States;welfare;Woman

PROJECT_TITLE: Fertility Among Women with Chronic Health Conditions: A Mixed Methods Study

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F18-E (20)]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

PHR: Narrative This proposal requests funds to support the 77th Annual Symposium of the Society of General Physiologists (SGP) titled `Molecular Evolution in the Membrane' from September 4th to September 8th, 2024, at the Marine Biological Laboratory (MBL) in Woods Hole, MA. The SGP annual symposium has an established international reputation as a leading meeting for physiologists, biophysicists, and molecular biologists at all career stages. The overarching goals of the 77th edition are to highlight cutting edge methods and transformative technologies that have led to advancements in understanding the origins of functional diversity in ion channels, transporters, and receptors, inspire and recognize young and diverse investigators who carry out this research, and to foster interdisciplinary collaborations across fields such as biophysics, physiology, structural biology, bioinformatics, and phylogenetics, which will contribute to foundational science in support of breakthroughs in human health.

PI_NAMEs: STOCKBRIDGE, RANDY B. (contact)

PROGRAM_OFFICER_NAME: UMANAH, GEORGE KWABENA ESSIEN

PROJECT_TERMS: Address;Allosteric Site;Animals;Applied Research;Area;Award;Basic Science;Bioinformatics;Biological;Biophysics;Black race;career;career development;Child Care;Child Support;childcare allowance;Complex;Creativeness;Cryoelectron Microscopy;Development;Discipline;diversity and inclusion;drug discovery;Electrophysiology (science);Ensure;Environment;equity, diversity, and inclusion;Fostering;fundamental research;Funding;Genetic Variation;Goals;graduate student;Health;Human;Human Genetics;Individual;insight;interdisciplinary collaboration;interest;International;Ion Channel;Laboratories;Language;Latinx;Machine Learning;marine;meetings;Membrane;Membrane Proteins;Membrane Transport Proteins;Methods;Michigan;Molecular;Molecular Evolution;Mutagenesis;National Institute of Neurological Disorders and Stroke;Nervous System Disorder;Neurologic;Neurosciences;non-tenure faculty;nonbinary;Pharmacology;Phylogenetic Analysis;Physiology;Postdoctoral Fellow;posters;programs;protein structure prediction;Proteins;Publishing;receptor;Request for Proposals;Research;Research Personnel;Research Project Grants;Science;Scientific Advances and Accomplishments;Scientist;single molecule;Societies;Structural Biochemistry;structural biology;Structure;Students;symposium;Technology;tool;Transmembrane Transport;Travel;United States;United States National Institutes of Health;Universities;Woman;Work

PROJECT_TITLE: Conference Funding: Society of General Physiologists "Molecular Evolution in the Membrane"

STUDY_SECTION_NAME: Special Emphasis Panel[ZNS1 SRB-K (43)]


NIH_SPENDING_CATS: Cerebrovascular;Congenital Structural Anomalies;Hematology;Neurosciences;Pediatric;Rare Diseases

ORG_CITY: NEW ORLEANS

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: UNCOVERING THE COMBINED EFFECTS OF VEGFA AND ANG2 PRO-ANGIOGENIC SIGNALING IN HEREDITARY HEMORRHAGIC TELANGIECTASIA Hereditary Hemorrhagic Telangiectasia (HHT) is a genetic vascular disease with sometimes lethal, non-curative arteriovenous malformations. The proposed research study will explore and compare the beneficial effects of potential therapeutic strategies in suppression of arteriovenous malformation development and assess their molecular impacts. The insight gained from these therapeutic, mechanistic studies may guide future HHT management options.

PI_NAMEs: BAVISHI, SHREYA  (contact)

PROGRAM_OFFICER_NAME: NEILSON, KAREN MARY

PROJECT_TERMS: activin receptor-like kinase 1;angiogenesis;Angiopoietin-2;Angiopoietins;Antibodies;Aortic Aneurysm;Appearance;Arteries;Arteriovenous malformation;bevacizumab;Biological Assay;Blood Vessels;Brain;brain arteriovenous malformations;Cancer Model;Cerebrovascular system;Cessation of life;Chronic;Clinical;Communication;Connective Tissue Diseases;density;Development;Diagnosis;Diameter;Disease;dosage;Dyes;Effectiveness;effectiveness evaluation;Endoglin;ENG gene;Enzyme-Linked Immunosorbent Assay;Epistaxis;experience;Extravasation;FDA approved;Frequencies;Future;Gastrointestinal Polyp;Genetic;Goals;Hemorrhage;Hereditary hemorrhagic telangiectasia;Human;improved;Individual;inhibitor;insight;Juvenile polyposis syndrome;KDR gene;Knowledge;Latex;Life;Light;Link;Liver;Lung;MADH4 gene;malformation;Malignant Neoplasms;Manuscripts;Mentorship;Microscopy;Molecular;mouse model;Mus;Mutation;Neurofibrillary Tangles;Operative Surgical Procedures;Organ;Pathologic;Pathology;Patients;Pharmaceutical Preparations;Phenotype;postnatal;pre-clinical assessment;Predisposition;prevent;Principal Investigator;Proteomics;Quality of life;rare variant;receptor;Reporting;Research;Research Design;research study;Resources;Retina;retina blood vessel structure;Role;Severities;Signal Pathway;Signal Transduction;Stains;Surface;symposium;targeted treatment;Technical Expertise;TEK gene;Telangiectasis;Testing;Therapeutic;therapeutically effective;Tissues;TNFSF15 gene;Training;transcription factor;transcriptomics;Transforming Growth Factor beta;Universities;vascular abnormality;Vascular Diseases;Vascular Endothelial Growth Factors;VEGFA gene;Veins;Writing

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F10C-D (20)]


NIH_SPENDING_CATS: Emerging Infectious Diseases;Infectious Diseases

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Project Narrative Encephalitozoon intestinalis is one of the most prevalent species of microsporidia found in humans and can lead to fatal disease in immunocompromised individuals. While E. intestinalis causes significant disease burden, our understanding of how these parasites develop within their host remains limited. Thus, using cellular, proteomic, and structural approaches we will investigate the molecular and cellular features of the replicative niche established during infection and uncover how these parasites successfully replicate within their host, ultimately leading to the development of novel therapeutic strategies which are currently limited.

PI_NAMEs: MCCARTY, KACIE  (contact)

PROGRAM_OFFICER_NAME: PESCE, JOHN T

PROJECT_TERMS: Anabolism;Apoptosis;Binding;Biotinylation;burden of illness;Carrier Proteins;Cell Nucleus;Cell Physiology;Cells;Complex;Cryo-electron tomography;Data;Development;Diarrhea;Disease;Environment;Face;Generations;genetic manipulation;Genome;Host Defense Mechanism;Human;Immunocompromised Host;Individual;Infection;Insecta;insight;Integration Host Factors;Knock-out;Maintenance;Mass Spectrum Analysis;Membrane;Membrane Proteins;Metabolic Pathway;Methods;Microsporidia;Microsporidiosis;Mitochondria;Molecular;Morphology;non-genetic;novel therapeutic intervention;Nuclear;Nutrient;Organelles;Parasites;pathogen;pathogenic fungus;Pathway interactions;Patients;permissiveness;Plasmodium falciparum;Process;protein complex;Protein Secretion;protein transport;Proteins;Proteome;Proteomics;recruit;Regulatory Pathway;Reproduction spores;Resolution;Role;Scanning Electron Microscopy;Septata intestinalis;Site;small molecule;Structure;Surface;Symptoms;timeline;tool;trafficking;Tube;Vacuole;Vesicle;Visualization;Wasting Syndrome;Work

PROJECT_TITLE: Investigating the molecular composition of the parasitophorous vacuole during Encephalitozoon intestinalis infection

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F07C-Y (20)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Neurosciences

ORG_CITY: CAMBRIDGE

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: HARVARD UNIVERSITY

PHR: Narrative The proposed research has broad relevance for neuroscience because it will provide new information about how reward-predicting signals are learned and represented stably in the brain. Understanding how information is stored in the face of continuous learning in the normal brain could help devise interventions in abnormal conditions.

PI_NAMEs: MURTHY, VENKATESH N (contact);UCHIDA, NAOSHIGE

PROGRAM_OFFICER_NAME: SABRI, MERAV

PROJECT_TERMS: addiction;Affect;Animal Behavior;Area;Association Learning;Behavior;Behavioral;behavioral outcome;Behavioral Paradigm;Brain;Brain region;Chemicals;Corpus striatum structure;Cues;Dopamine;DRD2 gene;Evaluation;experience;experimental study;flexibility;Genetic;Image;Intervention;Learning;learning progression;Light;Mediating;Monitor;motivated behavior;multiphoton imaging;Mus;nerve supply;neural;Neurons;Neurosciences;novel;Odors;olfactory bulb;Olfactory Cortex;Olfactory tubercle;Outcome;Output;Pattern;Physiology;piriform cortex;Population;Psychological reinforcement;Research;Resolution;reward processing;Rewards;Role;Schedule;Sensory;sensory input;Signal Transduction;Stimulus;Synapses;Synaptic plasticity;Testing;Training;Update;Ventral Striatum;Ventral Tegmental Area;Work

PROJECT_TITLE: Stability and flexibility of neural representations in the ventral striatum

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 ICN-T (02)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Pediatric;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_DEPT: PSYCHOLOGY

PHR: PROJECT NARRATIVE  Racism is increasingly becoming a public health concern which poses a risk for an increase in depression symptoms among Black Americans during adolescence and with recent studies indicating that Black fathers are salient and active participants in the parenting process,5, 25, 39 our understanding of the patterns of parenting strategies among Black fathers is limited. The overall goal of this NRSA proposal is to provide a methodologically rigorous examination of the heterogeneity of Black fathers’ parenting strategies and its protective capabilities on the long-term consequences of racism experiences on depression symptomatology among Black adolescents. The proposed research will 1) investigate the longitudinal stability of Black fathers’ paternal strategies subgroups and attenuating effects of parenting strategies among Black fathers on the relationship between racism exposure and depression symptoms among Black adolescents and 2) could inform theory and efforts to promote positive youth development in the face of racism.

PI_NAMEs: GIBSON, STEPHEN  (contact)

PROGRAM_OFFICER_NAME: ESPOSITO, LAYLA E

PROJECT_TERMS: Address;Adolescence;Adolescent;Adverse effects;Adverse event;Age;Articulation;assault;Attenuated;Awareness;Black American;Black race;career;Child;child depression;Child Development;Child Rearing;Childhood;Competence;contextual factors;critical developmental period;Data;Data Analyses;Data Set;depressive symptoms;Development;Economics;Ethnic Origin;experience;Exposure to;Family;fatherhood;Fathers;Fellowship;Goals;Grant;Heterogeneity;Intervention;Knowledge;Long-Term Effects;Longitudinal Studies;Longitudinal Surveys;Mental Depression;Mental Health;Methodology;Mothers;National Institute of Child Health and Human Development;National Research Service Awards;Outcome;parental monitoring;Parents;Participant;Pattern;person centered;positive youth development;Postdoctoral Fellow;preadolescence;Process;protective factors;Public Health;Race;racism;Research;research and development;Risk;Role;Sampling;Science;Scientist;Shapes;skills;Socialization;sociodemographic factors;sociodemographics;Stereotyping;Strategic Planning;Subgroup;symptomatology;Testing;Theoretical model;theories;Time;Training;Writing;Youth

PROJECT_TITLE: Parenting Profiles Among Black Fathers: Implications for Black Adolescents’ Depression Symptomatology


NIH_SPENDING_CATS: Digestive Diseases;Genetics;Liver Disease;Regenerative Medicine

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE Liver disorders affect 30 million people in the United States and a better understanding of hepatocyte biology is urgently needed to improve existing approaches and to innovate therapies for liver disease treatment. Polyploidy (increases in whole chromosome sets) is characteristic of the liver, yet the functions of diploid and polyploid hepatocytes are poorly understood. The comprehensive research plan will expand our understanding of hepatocyte ploidy populations and elucidate the specialized roles played by diploid and polyploid hepatocytes in acute liver injuries.

PI_NAMEs: WILSON, SIERRA  (contact)

PROGRAM_OFFICER_NAME: BODDIE, THOMAS ARTIS

PROJECT_TERMS: Acceleration;Acetaminophen;acetaminophen overdose;acetaminophen-induced liver injury;acute liver injury;Adult;Affect;American;Analgesics;Automobile Driving;Biology;Cause of Death;Cell Cycle Completion;cell injury;Cell Separation;Cessation of life;Characteristics;Chromosomes;cost;Development;Diploid Cells;Diploidy;effective therapy;end stage liver disease;experimental study;Extensive Necrosis;fatty liver disease;Gene Expression;global health;Goals;healing;Hepatic;Hepatocyte;Human;improved;In Vitro;in vivo;Injury;innovation;insight;Knock-out;Knowledge;Liver;Liver diseases;Liver Dysfunction;Liver Failure;liver injury;Liver Regeneration;liver transplantation;Modeling;Molecular;Mus;Natural regeneration;Organ;Organ Donor;oxidative damage;Oxidative Stress;Persons;Play;Ploidies;Polyploid Cells;Polyploidy;Population;Proliferating;regenerative;Regenerative response;Research;Resistance;response;response to injury;Role;Signal Transduction;Sirtuins;Somatic Cell;Testing;Therapeutic;therapeutic development;Toxic effect;Training;United States

PROJECT_TITLE: Role of hepatic ploidy populations in liver injury and compensatory regeneration after acetaminophen overdose

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Fellowships in Digestive Diseases and Nutrition[DDK-F]


ORG_CITY: Rockville

ORG_NAME: FEDERATION OF AMER SOC FOR EXPER BIOLOGY

ORG_STATE: MD

PHR: Project Narrative Lipid droplets play critical roles in energy metabolism and the etiology of numerous human diseases, such as obesity, type 2 diabetes, non-alcoholic fatty liver disease, atherosclerosis, cancer, and neurodegenerative disorders. A comprehensive understanding of the underlying processes of lipid droplets is paramount for the development of effective strategies to prevent and treat these prevalent diseases. The upcoming 9th FASEB Scientific Research Conference on Lipid Droplets will unite researchers from diverse scientific backgrounds and career stages, fostering lasting collaborations and discussions on important topics in lipid droplet biology and inspiring innovative research among the next generation of scientists.

PI_NAMEs: OLZMANN, JAMES A (contact)

PROGRAM_OFFICER_NAME: LIANG, HANYU

PROJECT_TERMS: Address;Atherosclerosis;Automobile Driving;Bacterial Infections;Biochemistry;Biogenesis;Biological Models;Biology;Biophysics;Biotechnology;Breathing;Caenorhabditis elegans;Cardiovascular Diseases;career;catalyst;Cellular biology;Chemicals;Clinical Research;Collaborations;Communities;Cultured Cells;Dedications;design;Development;Diabetes Mellitus;Disabled Persons;Discipline;Disease;diversity and inclusion;Educational workshop;empowerment;Energy Metabolism;Ensure;Environment;Etiology;Exclusion;Farm;Feedback;Fertilization;fly;Fostering;Funding;Future;Genetic;graduate student;Growth;Health;Heart;Homeostasis;Human;human disease;Image;Immune response;innovation;Insulin Resistance;interdisciplinary collaboration;Interdisciplinary Study;interest;International;Intervention;Knowledge;Link;lipid disorder;lipid metabolism;lipidomics;Lipids;Lipodystrophy;Malignant Neoplasms;meetings;membrane biogenesis;Metabolic Diseases;Methods;Minnesota;Mission;Molecular;multidisciplinary;Mus;Nerve Degeneration;Neurodegenerative Disorders;next generation;non-alcoholic fatty liver disease;Non-Insulin-Dependent Diabetes Mellitus;novel therapeutics;Obesity;Organelles;Participant;pathogen;Pathogenesis;Pathologic;Physiology;Play;Postdoctoral Fellow;posters;Prevalence;prevent;Process;Published Comment;Research;Research Personnel;Role;Running;Saints;Scientist;Shapes;Signal Transduction;skills;summer research;symposium;Technology;Therapeutic;therapeutic development;Thinking;trafficking;Training;Underrepresented Minority;Virus Diseases;Vocational Guidance;Voice;Woman;Work;Yeasts

PROJECT_TITLE: Lipid Droplets

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-7 (J3)]


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Congenital Structural Anomalies;Intellectual and Developmental Disabilities (IDD);Mucopolysaccharidoses (MPS);Neurosciences;Orphan Drug;Pediatric;Rare Diseases

ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Project Narrative The AAVtcm8-coNAGLU vector dosing, biodistribution and toxicology will be determined. The vector production optimizations and assays of potency, neutralizing antibody, gene product and storage product assays will be performed. Information sufficient for FDA pre-IND and IND submissions will be compiled and approvals obtained.

PI_NAMEs: BYRNE, BARRY J;HELDERMON, COY D (contact)

PROGRAM_OFFICER_NAME: FRIEDMAN, LAUREN GENIENE

PROJECT_TERMS: Address;Age;analytical method;Antibodies;Biodistribution;Biological Assay;Brain;Canis familiaris;Capsid;cell bank;Cerebrospinal Fluid;Cesarean section;Cessation of life;cisterna magna;Clinical;Clinical Protocols;Clinical Research;Codon Nucleotides;Collaborations;Contracts;Data;design;Development;Disease;disease model;Dose;Ensure;enzyme deficiency;Enzymes;FDA approved;Formulation;Funding;gene product;Glucosaminidase;good laboratory practice;Hearing;Heparitin Sulfate;Immune;Immune response;Injections;Investigational Drugs;life span;Lysosomal Storage Diseases;manufacture;manufacturing organization;manufacturing process;manufacturing run;manufacturing scale-up;method development;Methods;mouse model;Mucopolysaccharidosis III;Mucopolysaccharidosis III B;Mus;Mutate;Nerve Degeneration;neutralizing antibody;Neutralizing antibody assay;New Drug Approvals;nonhuman primate;novel;Pharmaceutical Preparations;Phase;pre-clinical;pre-Investigational New Drug meeting;Process;process repeatability;Production;programs;Proteins;Protocols documentation;Reagent;Reproducibility;Running;Serotyping;Serum;therapeutic gene;Tissues;Toxic effect;Toxicology;United States National Institutes of Health;vector;Viral;Virus;Weight;Writing

PROJECT_TITLE: Procession to IND of a capsid mutated AAV8 codon optimized NAGLU vector for treatment of Sanfilippo Syndrome type B

STUDY_SECTION_NAME: Special Emphasis Panel[ZNS1 SRB-Q (09)]


NIH_SPENDING_CATS: Cancer;Genetics

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE The poorly characterized initiation factor eIF2A functions in an alternate translation initiation pathway during times of cellular stress. This factor has been implicated in the translation initiation of viral and oncogenic mRNA through classical AUG and near-cognate start codons. The proposed research will contribute to a fundamental understanding of how eIF2A selectively binds and recruits tRNA to the ribosome to facilitate activation of this non-canonical initiation pathway.

PI_NAMEs: FERRELL, AARON  (contact)

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TERMS: 7-methylguanosine;Amino Acid Sequence;anti-cancer therapeutic;Anticodon;antiviral drug development;Base Pairing;Binding;Biochemical;biological adaptation to stress;Bypass;c-myc Genes;C-terminal;cancer cell;cancer therapy;cell growth regulation;Cell Line;Cells;Cellular Stress;Cistrons;Co-Immunoprecipitations;Codon Nucleotides;Complex;Cryoelectron Microscopy;Crystallography;Data;Dependence;Disease;Down-Regulation;EIF-2alpha;Elements;Eukaryotic Initiation Factor-2;Eukaryotic Initiation Factors;Event;Exhibits;experimental study;Fission Yeast;Future;Health;Hepatitis C virus;Human;Immunoglobulin binding proteins;inhibitor;Initiator Codon;Initiator tRNA;insight;interest;Internal Ribosome Entry Site;knock-down;Luciferases;Malignant Neoplasms;Mediating;Messenger RNA;mRNA Translation;novel;Nucleotides;Oncogenes;Oncogenic;overexpression;Paclitaxel;particle;Pathogenicity;Pathway interactions;Peptide Initiation Factors;Phosphorylation;Play;Polyproteins;prevent;Process;Protein Biosynthesis;Proteins;Proto-Oncogene Proteins c-myc;Proto-Oncogenes;Reading;Recovery;recruit;Reporter;Reporting;Research;Resolution;Ribosomes;Role;Specificity;src-Family Kinases;Stress;Structure;Techniques;Therapeutic;Transfection;Transfer RNA;Translating;Translation Initiation;Translation Process;Translations;tumor;tumor growth;Tunicamycin;Untranslated Regions;Viral;Viral Cancer;Virus;Virus Diseases;X-Ray Crystallography

PROJECT_TITLE: Mechanism of translation initiation through the non-canonical initiation factor eIF2A

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F08-L (20)]


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Disability Research;Epilepsy;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurodegenerative;Neurosciences;Pediatric

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it seeks to understand how synaptic dysfunction of inhibitory interneurons contribute to disease phenotypes of human disorders due to pathogenic loss-of-function variants in the X-linked gene CASK. Lack of knowledge about how loss of the protein CASK contributes to neuronal dysfunction and how this dysfunction connects to disease phenotypes has limited the ability to develop therapeutics to alleviate symptoms or prevent disease. Furthermore, this project is applicable to the NIH’s mission because it will provide fundamental knowledge about the cellular mechanisms of intellectual disability and epilepsy, common symptoms across numerous neurodevelopmental disorders. .

PI_NAMEs: JIANG, KEVIN  (contact)

PROGRAM_OFFICER_NAME: OREILLY, JULIA JIAQI

PROJECT_TERMS: Absence Epilepsy;Acute;Address;Anticonvulsants;APBA1 gene;Binding;Biological Assay;Brain;Calcium;Calmodulin;career;Cell Count;cell type;Cells;Child;Childhood;Clinical;Cognitive deficits;cognitive performance;college;common symptom;comorbidity;conditional knockout;Data;de novo mutation;design;Development;developmental disease;Diagnosis;Disease;disease phenotype;Electroencephalography;Electrophysiology (science);Environment;Epilepsy;excitatory neuron;experience;experimental study;Female;Functional disorder;Genes;genetic manipulation;Genetic Recombination;Goals;Heterogeneity;Heterozygote;Homeostasis;Human;human model;Image;Impairment;improved;In Vitro;in vivo;inhibitory neuron;insight;Intellectual functioning disability;Interneurons;Investigation;knock-down;Knock-out;Knockout Mice;Knowledge;Learning;Link;Location;loss of function;LoxP-flanked allele;male;Measures;Medical center;Medicine;Memory;Mission;Modeling;Molecular;Mosaicism;mouse model;Mus;Myoclonic Epilepsies;Neurodevelopmental Disorder;Neurologic;Neurologist;Neuronal Dysfunction;Neurons;neuropsychiatric disorder;neurotransmitter release;novel;novel therapeutics;Outcome;Output;patch clamp;Pathogenesis;Pathogenicity;Pathology;Patients;Penetrance;Pharmacotherapy;Phenotype;Population;postsynaptic;postsynaptic neurons;presynaptic;presynaptic neurons;prevent;Probability;Property;Prosencephalon;Protein-Serine-Threonine Kinases;Proteins;Public Health;reduce symptoms;Research;Research Institute;Resistance;Scaffolding Protein;Severities;Slice;success;Symptoms;Synapses;synaptic function;Synaptic Transmission;Syndrome;targeted treatment;Techniques;Technology;Testing;Texas;Therapeutic;therapeutic target;Training;Translating;two-photon;United States National Institutes of Health;Variant

PROJECT_TITLE: Inhibitory neuron dysfunction in intellectual disability and epilepsy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F01A-V (20)]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cardiovascular;Genetics;Heart Disease;Nutrition;Obesity;Physical Activity;Prevention

ORG_CITY: SYRACUSE

ORG_NAME: UPSTATE MEDICAL UNIVERSITY

PHR: PROJECT NARRATIVE This project aims to investigate the activation mechanisms of myokine signaling in response to mitochondrial protein import stress. We will validate the role of a specific myokine in promoting body mass homeostasis and cardiac health. This research holds the potential to advance our understanding of cellular stress adaptation and its implications for metabolic and cardiovascular health, opening new avenues for targeted therapeutic interventions to reduce the burden of metabolic and cardiovascular diseases.

PI_NAMEs: MAURO, JOSEPH V. (contact)

PROGRAM_OFFICER_NAME: FU, YI-PING

PROJECT_TERMS: Ablation;Adipose tissue;aged;Aging;Animals;Bioenergetics;Biology;Body mass index;Body Weight;Bone Growth;Brown Fat;Calories;Cardiac;Cardiac health;Cardiac Myocytes;cardioprotection;Cardiovascular Diseases;cardiovascular health;Cell Line;Cells;Cellular Stress;Cessation of life;Communication;Coupled;Cytosol;Death Rate;Defect;Development;Disease;EFRAC;Exercise;Fatty acid glycerol esters;Fellowship;fibroblast growth factor 21;Foundations;Genes;Health;Health Promotion;healthy aging;Heart;heart function;Homeostasis;Immunoprecipitation;improved;in vivo;Individual;Intervention;Knock-out;Knockout Mice;Knowledge;Lipolysis;Mass Spectrum Analysis;Mediating;Mediator;Metabolic;Metabolic Diseases;Metabolic stress;Mitochondria;Mitochondrial Diseases;Mitochondrial Membrane Protein;Mitochondrial Proteins;Modeling;Molecular;mortality risk;mouse model;Mus;Muscle;mutant;Neurons;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutic intervention;Nuclear;Obesity;obesity risk;old mice;Organ;overexpression;Pathway interactions;Patients;Persons;Phenotype;Physical activity;Physical Endurance;Physical Exercise;Play;Population;pre-doctoral;Production;Protein Import;Reperfusion Injury;Research;response;Risk Reduction;Role;saluretic;Signal Transduction;SLC25A4 gene;Stress;success;targeted treatment;Testing;Therapeutic Intervention;therapeutic target;therapeutically effective;Thinness;Tissues;Transcription Coactivator;transcription factor;transcriptome;Transgenic Mice;Transgenic Organisms;translational potential;United States

PROJECT_TITLE: Mechanism of mitochondria-induced myokine activation and implications for healthy aging.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F06-L (20)]


NIH_SPENDING_CATS: Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza

PHR: Pneumonia remains the leading killer of children globally and a significant cause of morbidity and mortality in the US. We aim to study how immune cells function in the lung and how they communicate with lung fibroblasts to protect the host from bacterial pneumonia.

PI_NAMEs: REMCHO, THOMAS PARKS (contact)

PROGRAM_OFFICER_NAME: ESPINOZA-PINTUCCI, MARISOL

PROJECT_TERMS: antimicrobial;Bacteria;Bacterial Pneumonia;bactericide;beta-Chemokines;Binding;Biological Assay;Biology;Bone Marrow;bronchial epithelium;Bronchoalveolar Lavage Fluid;Cell Line;cell motility;Cell Physiology;Cell Separation;Cells;chemokine;chemokine therapy;Child;Communication;Complement;CXC Chemokines;cytokine;Data;Dependence;Development;Diagnosis;Drug resistance;Effector Cell;Enterobacteriaceae;Epigenetic Process;Epithelial Cells;experimental study;Exposure to;Fibroblasts;Flow Cytometry;Foundations;Generations;Genetic Transcription;Goals;HIF1A gene;Human;IL17 gene;Immune;Immunology;improved;In Vitro;in vivo;interstitial;ITGAM gene;ITGAX gene;Klebsiella pneumoniae;knock-down;Location;Lung;Lung Lavage Fluid;Macrophage;Measures;Memory;Methods;Modification;monocyte;Morbidity - disease rate;mortality;mRNA Stability;Mucous Membrane;Mus;Muscle Cramp;Myelogenous;Myeloid Cells;Neutrophil Infiltration;Nose;pathogen;Phenotype;Physicians;Pneumonia;Population;receptor;recruit;Regulation;Research;residence;resilience;Respiratory System;response;Role;Scientist;Signal Transduction;Sorting;Structure of parenchyma of lung;Surface;Testing;Th1 Cells;Tissues;TLR4 gene;TNF gene;Training;Transforming Growth Factor beta;vaccine efficacy;Vaccines;Validation;Work;XCL1 gene

PROJECT_TITLE: Lung Th17 cells signal via fibroblasts,  establish interstitial macrophages, and contribute to host protection

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F10A-K (20)]


NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: Project Narrative The maternal and neonatal morbidity and mortality crisis in the US has led to implementation of numerous state-level initiatives and policies aimed at changing clinical practices to improve outcomes. However, some newborn initiatives were designed and implemented with little mention of maternal outcomes, and evidence on the effect of these initiatives is limited and mixed. This study will use recent methodologic innovations to address evidence gaps and evaluate the effects of state-level initiatives to reduce early-term elective deliveries (i.e., non-medically indicated labor inductions and c-sections occurring before 39 weeks gestational age) on both maternal and newborn outcomes and disparities in outcomes; results will inform future adaptation and development of state-level initiatives to improve perinatal outcomes.

PI_NAMEs: HUGHES, CAROLYN SMITH (contact)

PROGRAM_OFFICER_NAME: CHINN, JUANITA JEANNE

PROJECT_TERMS: Address;Admission activity;adverse outcome;Arizona;Birth;Birth Certificates;Birth trauma;California;career;Caring;Cesarean section;Cessation of life;Child;Clinical;clinical care;clinical practice;Colorado;comparative effectiveness study;cost;Data;Data Set;Data Sources;Databases;design;Development;Disparity;doctoral student;Education;Ensure;Epidemiologist;Epidemiology;epidemiology study;Ethnic Origin;Etiology;Evaluation;Exclusion;experience;Family;Fellowship;Florida;Foundations;Future;Gestational Age;Goals;Grant;health care service utilization;health disparity;Health Policy;Health Services;Health Services Research;hospital readmission;Hospitals;Hypertension;Icterus;improved;improved outcome;Individual;Individual National Research Service Award;Induced Labor;Infant;Infection;innovation;Insurance;Intensive Care;Intervention;Knowledge;Length of Stay;Link;Louisiana;Massachusetts;maternal morbidity;Maternal Mortality;maternal outcome;Measurement;Measures;Medical;Mentors;Mentorship;Methodology;Methods;Michigan;Modeling;Morbidity - disease rate;mortality;Mothers;National Institute of Child Health and Human Development;Neonatal Intensive Care Units;neonatal morbidity;Nevada;New Jersey;New York;Newborn Infant;novel strategies;Oregon;Outcome;Outcomes Research;payment;Pennsylvania;Perinatal;Perinatal Care;Perinatal Epidemiology;perinatal health;perinatal outcomes;Physicians;Policies;Policy Research;Postpartum Hemorrhage;pre-doctoral;Pregnancy;Pregnancy Outcome;programs;Publishing;Quasi-experiment;Race;Recommendation;Research;Research Personnel;respiratory distress syndrome;Risk;Rural;Sepsis;severe maternal morbidity;skills;social determinants;South Carolina;Strategic Planning;structural determinants;Subgroup;Tennessee;Training;United States National Institutes of Health;urban residence;US State;Variant;Virginia;West Virginia;Woman;Women's Health;Work

PROJECT_TITLE: Effects of state-level initiatives to reduce early-term elective deliveries on maternal and newborn outcomes


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Aging;Biotechnology;Eye Disease and Disorders of Vision;Genetics;Human Genome;Neurodegenerative;Neurosciences

ORG_CITY: WEST LAFAYETTE

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: Narrative Oxidative stress contributes to the development and progression of ocular diseases including cataracts, glaucoma, age-related macular degeneration, and diabetic retinopathy. One-carbon metabolism influences the response to oxidative stress via antioxidant biosynthesis; however, this pathway is also perturbed by oxidative stress in the eye. In these studies, I propose that oxidative stress leads to the oxidation of Adenosylhomocysteinase (Ahcy) inhibiting its activity, resulting in increased SAH and decreased methylation capacity.

PI_NAMEs: STANHOPE, SARAH  (contact)

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: Adenosine;Adenosylhomocysteinase;Age related macular degeneration;Anabolism;Antioxidants;assay development;Binding;Biochemical;Bioinformatics;Biological Assay;Carbon;career;Cataract;Cell Physiology;Cells;Cleavage Under Targets and Release Using Nuclease;Cultured Cells;Cysteine;Data;Development;Diabetic Retinopathy;dimedone;DNA Methylation;Down-Regulation;Drosophila eye;Drosophila genus;Drug Industry;enzyme activity;Enzymes;epigenome;Eukaryota;experimental study;Eye;Eye diseases;fly;Foundations;Future;Gene Expression;Genes;Genetic;genetic manipulation;genome-wide;genomic locus;Glaucoma;Goals;histone methylation;Homocysteine;Human;Hydrogen Peroxide;Hydrolysis;Impairment;In Vitro;in vitro Assay;in vivo;indexing;knock-down;large scale data;Light;Metabolism;Methionine;methyl group;Methylation;methylome;Methyltransferase;Modeling;Modification;Mutation;neuroprotection;novel;Optics;oxidation;Oxidation-Reduction;Oxidative Stress;Oxidative Stress Induction;Pathway interactions;Point Mutation;Predisposition;prevent;protein purification;Proteins;Proteomics;Reaction;Recombinant Proteins;Regulation;response;Retina;retinal damage;Retinal Degeneration;S-Adenosylhomocysteine;S-Adenosylmethionine;sensor;Signal Transduction;Site-Directed Mutagenesis;skills;Stress;targeted treatment;Testing;transcriptome sequencing;Transgenic Organisms

PROJECT_TITLE: Characterizing Ahcy as a redox regulated enzyme in the Drosophila eye under oxidative stress

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F03B-L (20)]