ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Depression;Mental Health;Mental Illness;Neurosciences

ORG_CITY: ATLANTA

ORG_DEPT: PSYCHOLOGY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Converging evidence suggests that stress induced alterations in dopamine contribute to behavioral and neurocognitive correlates of anhedonia. However, limitations associated with popular dopamine imaging techniques have made it difficult to clarify this mechanism. The proposed study aims to use neuromelanin magnetic resonance imaging to better understand the neurobiological mechanism underlying stress-induced anhedonia.

PI_NAMEs: TREADWAY, MICHAEL TILGHMAN (contact)

PROJECT_TERMS: Anhedonia;Behavioral;Chronic stress;Clinical Research;Corpus striatum structure;cost;depressive symptoms;Development;Dopamine;dopaminergic neuron;Exposure to;Functional Magnetic Resonance Imaging;Glutamates;Human;Image;Imaging Techniques;in vivo;interest;Ketamine;life span;Link;Magnetic Resonance Imaging;Measurement;Measures;Motivation;neural;neurobiological mechanism;Neurocognitive;neuroimaging;neuromelanin;Neurotransmitters;non-invasive imaging;Patient Self-Report;Physiological;Pigments;Positron-Emission Tomography;Postdoctoral Fellow;preclinical study;Proxy;Radiation;Research Personnel;Rewards;Risk Factors;Signal Transduction;Stress;suicidal risk;Techniques;treatment response;willingness;Work

PROJECT_TITLE: Glutamatergic adaptation to stress as a mechanism for anhedonia and treatment response with ketamine

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


ADMINISTERING_IC: CA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: LA JOLLA

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PHARMACOLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: Narrative The UC San Diego Faculty Institutional Recruitment for Sustainable Transformation (FIRST) Program seeks to employ a faculty cohort model to transform cultures of inclusive excellence and sustain our commitment to diversity and inclusion in biomedical research. We will create and foster an institutional environment of faculty hiring, sponsorship, continual mentoring, and support for professional development to cultivate an academic culture of inclusive excellence. We will develop and implement an evaluation plan to demonstrate how cluster hires and implementation of structured system-wide evidence-based faculty development programs enhance underrepresented faculty academic advancement and success, lead to institutional inclusive excellence, increase diversity and improve institutional climate for all faculty.

PI_NAMEs: MARTINEZ, MARIA ELENA;TREJO, JOANN  (contact)

PROGRAM_OFFICER_NAME: CALZOLA, JESSICA MARIE

PROJECT_TERMS: Address;Advanced Development;Biomedical Research;California;career development;cohort;community building;Development;Development Plans;diversity and inclusion;Elements;Environment;equity, diversity, and inclusion;Ethnic Origin;Evaluation;evidence base;Evidence based practice;Faculty;Faculty Recruitment;faculty support;Fostering;Goals;health equity;improved;Individual;innovation;Institution;Knowledge;Lead;Leadership;Mentors;Mentorship;Modeling;organizational climate;Program Development;programs;Race;recruit;Research;research and development;Scientist;Secure;Strategic Planning;Structure;success;supportive environment;System;Teacher Professional Development;United States National Institutes of Health;Universities;Woman

PROJECT_TITLE: UC San Diego FIRST Program


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

ORG_CITY: ALBUQUERQUE

ORG_NAME: UNIVERSITY OF NEW MEXICO

ORG_STATE: NM

PHR: Project Narrative The University of New Mexico (UNM) FIRST program seeks to improve public health by hiring a diverse cohort of early career faculty in neuroscience and data science and ultimately fostering sustained, inclusive excellence within the institution. This initiative aims to diversify the biomedical faculty workforce, providing crucial role models for underrepresented minorities and supporting the next generation of NIH-funded scientists. Additionally, the program's efforts and supplemental funding support collaboration, community- building, and professional development among FIRST Faculty at the annual Grantees Meetings, contributing to a nationwide network for inclusive excellence.

PI_NAMEs: SALINAS, IRENE ;SMITH, JANE ELLEN  (contact)

PROJECT_TERMS: Administrative Supplement;Arts;cohort;Collaborations;college;Communication;Communities;community building;Data Science;Development;diversity and inclusion;early-career faculty;Faculty;faculty support;Female;Fostering;Funding;Goals;Hispanic-serving Institution;improved;innovation;Institution;Leadership;meetings;Minority;Mission;Modeling;Neurosciences;New Mexico;next generation;peer networks;programs;Public Health;recruit;Research;Research Activity;Research Personnel;role model;Science;Scientist;success;symposium;Training;Travel;Underrepresented Minority;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: UNM FIRST: Promoting Inclusive Excellence in Neuroscience and Data Science - Administrative Supplement to support FIRST Faculty Travel


ADMINISTERING_IC: EY

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Eye Disease and Disorders of Vision;Microbiome

ORG_CITY: BALTIMORE

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE While the resident microbiota has been extensively characterized in many parts of the human body, such as the gut, the ocular surface microbiome is relatively understudied. This is in part due to the unique challenges of characterizing a broad range of organisms in specimens that have low microbial biomass, such as those collected from the ocular surface. Here, we describe the systematic optimization of sample processing methods, validation of computational tools, and longitudinal characterization of the composition and viability of organisms comprising the healthy ocular surface microbiome.

PI_NAMEs: ENSIGN, LAURA  (contact);SALZBERG, STEVEN L.

PROGRAM_OFFICER_NAME: GAO, JAMES

PROJECT_TERMS: Address;analytical method;analytical tool;Biomass;Biopsy;Body Surface;Brain;Cerebrospinal Fluid;Clinical;Clinical assessments;Collection;computerized tools;Data Set;Detection;Development;Diagnostic tests;Disease;Environment;Epithelium;Eye;female reproductive tract;Guidelines;Homeostasis;Human body;Laboratories;metagenome;metagenomic sequencing;Metagenomics;Methods;Microbe;microbial;microbiome;microbiota;microorganism;Mucous Membrane;multidisciplinary;ocular surface;open source;Organism;Paraffin Embedding;Participant;pathogen;patient population;Procedures;Protocols documentation;Resources;sample collection;Sampling;Site;Skin;Software Tools;Source;Specimen;Specimen Handling;Standardization;Surface;Tissues;tool;Validation

PROJECT_TITLE: Development of standardized resources for characterization of the resident ocular surface microbiome.


ADMINISTERING_IC: TW

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Pediatric;Prevention;Social Determinants of Health;Violence Research

ORG_CITY: Los Angeles

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: PROJECT NARRATIVE Physical, verbal and sexual abuse documented in boarding schools in Zambia are strongly linked to stigma and discrimination and heighten HIV stigma experiences for those affected by HIV both at school and beyond; given the impact of HIV-related stigma and discrimination on HIV-related outcomes, there is a compelling need for HIV stigma reduction in boarding schools within a broader context of safeguarding to foster deeper acceptance of HIV. This study seeks to adapt the ‘total facility approach’ to addressing HIV-related stigma and discrimination in healthcare settings and pilot-test it in boarding school communities, including individuals living with HIV and individuals who are not. Intervention packages will be co-created with school stakeholders and will target learners, teachers, staff, and staff from nearby healthcare facilities to create a community of safety characterized by reduced experiences of HIV-related stigma and abuse so as to lower barriers to engagement in care within the boarding school setting and equip young people with skills to better navigate HIV.

PI_NAMEs: BOND, VIRGINIA ;FERGUSON, LAURA  (contact)

PROGRAM_OFFICER_NAME: BANSAL, GEETHA PARTHASARATHY

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Affect;Africa South of the Sahara;AIDS prevention;Anti-Retroviral Agents;Attention;Attitude;Awareness;Behavior;Caring;Child;Clinical;Communities;Complex;Consequences of HIV;Data;Data Collection;Disclosure;Discrimination;Drops;Education;Elements;Environment;Exclusion;experience;Fostering;Friends;Government;Health;Health care facility;health care settings;health related quality of life;Healthcare;HIV;HIV risk;implementation barriers;implementation evaluation;implementation facilitators;implementation fidelity;implementation intervention;implementation research;improved;Individual;insight;Intervention;Intervention Studies;Learning;Link;Measures;Methods;multidisciplinary;Names;neighborhood safety;Outcome;Outcome Measure;Participant;Patient Self-Report;perceived discrimination;Persons;Pharmaceutical Preparations;Phase;physical abuse;pilot test;Population;primary outcome;Privatization;process evaluation;Province;Questionnaires;Reporting;Research;Research Design;response;Rights;Risk Reduction Behavior;Running;Sampling;scale up;school environment;Schools;secondary outcome;Self Administration;self esteem;Services;Sexual abuse;skills;social stigma;Stigmatization;Structure;Students;Surveys;Tablets;teacher;Training;Verbally abusive behavior;Violence;Virginia;Work;Youth;Zambia

PROJECT_TITLE: A total school approach using safeguarding to address HIV-related stigma and discrimination in boarding schools in Zambia

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Social Determinants of Health;Women's Health Research

PHR: PROJECT NARRATIVE This proposed study addresses a highly relevant public health question: how to reduce individual-level stigma around HIV and drug use that may undermine people’s ability to seek and remain engaged in HIV care. This study will take place in Ukraine, which continues to experience one of the highest HIV rates in Europe. The information gained through this study has the potential to inform the development of policies and practices to help people living with HIV maintain access to and engaged in HIV care.

PI_NAMEs: KIRIAZOVA, TETIANA ;OWCZARZAK, JILL  (contact)

PROJECT_TERMS: Address;Adherence;Affect;AIDS prevention;Appointment;Area;arm;Attitude;Behavioral;care outcomes;care systems;Caring;Clinical;Cognitive;Communication;contextual factors;coping;cost;Data;development policy;Dimensions;Disadvantaged;Drug usage;Educational workshop;effectiveness evaluation;Effectiveness of Interventions;Enrollment;Europe;Evaluation;expectation;experience;Gender;Goals;Harm Reduction;Health;Health behavior and outcomes;health care availability;Health care facility;health care service utilization;Health Status;HIV;HIV/AIDS;implementation outcomes;implementation process;improved;Individual;Injections;internalized stigma;Intervention;intervention participants;Interview;low and middle-income countries;Measures;Medical;Medical Records;medication compliance;men;Mental Health;Modeling;novel;Outcome;Outcome Assessment;Participant;Patient Self-Report;Persons;Pharmacotherapy;Pilot Projects;poor health outcome;Population;post intervention;Practical Robust Implementation and Sustainability Model;Process;Productivity;Provider;psychologic;Public Health;Randomized;Reporting;Research;Research Priority;Research Proposals;Resources;Risk Behaviors;secondary outcome;Services;skills;social stigma;Social support;Social Workers;Stigmatization;Stress;Structure;substance use;Testing;Training;Ukraine;United States National Institutes of Health;Woman

PROJECT_TITLE: Adaptation and evaluation of an intersectional stigma reduction intervention to increase HIV care engagement among women who use drugs


ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE In this R01 study, we will adapt, and pilot test the Kupambana intervention to address intersectional HIV and poverty stigmas and their impact on mental health, progression across the HIV continuum of care, and mechanisms of change, such as stigma, among young people with HIV in Zambia. The pilot test of Kupambana will evaluate its feasibility, acceptability, implementation costs, and preliminary effects. If findings show promise, this research will form the basis of a subsequent type 1 hybrid effectiveness-implementation investigation of Kupambana.

PI_NAMEs: MASA, RAINIER DEVERA (contact);ZULU, JOSEPH MUMBA

PROJECT_TERMS: acceptability and feasibility;Address;Age;AIDS prevention;antiretroviral therapy;Budgets;care outcomes;Caring;Collaborations;Communities;Continuity of Patient Care;Coping Skills;cost;Country;Data;Development;Economic Conditions;Economics;Education;effectiveness/implementation hybrid;effectiveness/implementation trial;Emotional;empowerment;Entrepreneurship;Evaluation;experience;Fees;Female;financial literacy;follow up assessment;follow-up;Foundations;Funding;Future;Goals;Health;Health Disparities Research;HIV;implementation cost;implementation determinants;implementation process;improved;Inequity;internalized stigma;International;Intervention;intervention refinement;Interview;Investigation;low and middle-income countries;male;medication compliance;Mental Health;Methodology;Modeling;mortality;Names;operation;Outcome;Participant;Personal Satisfaction;Persons;Phase;pilot test;Population;Poverty;Prevalence;Procedures;Process;Production;Program Sustainability;programs;Protocols documentation;Province;Psychosocial Assessment and Care;Public Health;Randomized;Recording of previous events;Research;resilience;Resources;response;Sampling;Savings;Secondary Schools;Self Care;Self Efficacy;service providers;skills;skills training;social stigma;social structure;Structure;Support Groups;Surveys;Testing;theories;Training;treatment as usual;Unemployment;United States National Institutes of Health;usual care arm;Vocation;voucher;Work;young adult;Youth;Zambia

PROJECT_TITLE: Kupambana: A Combined Microeconomic Strengthening and Stigma Reduction Intervention for Young People with HIV in Zambia


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease;Regenerative Medicine

ORG_CITY: DURHAM

ORG_DEPT: SURGERY

ORG_NAME: DUKE UNIVERSITY

PHR: Narrative (relevance): Elucidating novel roles for -adrenergic receptor (AR) signaling regulation in the heart by the nitric oxide (NO) system via S-nitrosylation (SNO) will lead to a broader understanding of mechanisms of cardiac injury and repair. This includes several targets (i.e. receptor, GRK2 and -arrestins) that have the potential for discovering novel therapeutic strategies for heart failure. Finally, studying cardiac ARs for outcomes of NO/SNO regulation in (patho)physiology can be a model system for other GPCRs and organ systems.

PI_NAMEs: KOCH, WALTER J. (contact);STAMLER, JONATHAN S.

PROGRAM_OFFICER_NAME: SCHWARTZ, LISA

PROJECT_TERMS: Acute;ADRBK1 gene;Adrenergic Agents;Adrenergic Receptor;Affect;Aging;Arr2;Arrestins;beta-adrenergic receptor;beta-arrestin;Binding;Biological Models;Body System;Cardiac;Cardiac Myocytes;cardiac repair;cardioprotection;Cardiovascular system;Catecholamines;Cell Physiology;Cessation of life;Chronic;Collaborations;Cyclic GMP-Dependent Protein Kinases;Cysteine;Data;Defect;desensitization;Development;Disease;Down-Regulation;Enzymes;Evaluation;Functional disorder;G protein coupled receptor kinase;G Protein-Coupled Receptor Signaling;G-Protein-Coupled Receptors;Goals;Guanylate Cyclase;Health;Heart;Heart failure;heart function;Heart Injuries;Hybrids;Impairment;improved;Injury;injury and repair;innovation;insight;Ischemia;ischemic injury;Knock-in Mouse;Laboratories;Mediating;Modeling;Modification;mouse model;Mus;Muscle Cells;mutant;Mutant Strains Mice;Myocardial;Myocardial dysfunction;Myocardial Ischemia;Myocardium;Neurons;Nitric Oxide;Nitric Oxide Synthase;NOS2A gene;NOS3 gene;novel;novel therapeutic intervention;Organ;Outcome;Oxidation-Reduction;Pathogenesis;Pathologic;Pathology;Phosphorylation;Phosphotransferases;Physiological;Physiology;Play;Post-Translational Protein Processing;Property;Protein Isoforms;Protein S;Proteins;Reaction;Reagent;receptor;receptor function;Receptor Signaling;Refractory;Regulation;repaired;response;response to injury;Role;S-Nitrosothiols;Signal Transduction;Site;Stress;Sulfhydryl Compounds;System;Testing;Therapeutic;Therapeutic Intervention;Translations;Work

PROJECT_TITLE: Role of S-Nitrosylation on Beta-Adrenergic Signaling in Cardiac Injury and Repair

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MIM-R(01)]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Infectious Diseases;Maternal Health;Maternal Morbidity and Mortality;Prevention;Women's Health Research

ORG_DEPT: OBSTETRICS & GYNECOLOGY

PHR: NARRATIVE In this K24 renewal, Dr. Benjamin Chi proposes to continue his successful mentoring program focused on HIV prevention in pregnancy and postpartum. This research will provide new insights about how perceptions of HIV risk influence the use of HIV prevention interventions (in this case, pre-exposure prophylaxis) during these periods. It will also provide a platform to train promising, early-stage researchers in this emerging and important field.

PI_NAMEs: CHI, BENJAMIN H. (contact)

PROGRAM_OFFICER_NAME: CHIOU, CHEN-CHIA CHRISTINE C

PROJECT_TERMS: Address;Adherence;Africa South of the Sahara;African;AIDS prevention;Altruism;Assessment tool;Award;Behavior;Biological;Blood;career;Clinical;clinical practice;Clinical Trials;cohort;Collaborations;Country;Dapivirine;Data;Decision Making;Dedications;design;Development;Diphosphates;Dryness;educational atmosphere;effective therapy;emtricitabine;Enrollment;Environment;Evaluation;feasibility testing;Formulation;Fostering;Fumarates;Funding;Future;global health;Goals;Health;HIV;HIV Infections;HIV risk;Home;Household;human centered design;implementation research;improved;Individual;Injectable;insight;Institution;International;International Maternal Pediatric Adolescent AIDS Clinical Trials;Intervention;intervention refinement;Interview;Joints;Leadership;Learning;life span;Malawi;Maternal and Child Health;Maternal Health;Measurement;Mentors;Mentorship;Methods;Monitor;Mother-to-child HIV transmission;Mothers;Motivation;multidisciplinary;Newborn Infant;Oral;Participant;participant enrollment;patient oriented;peer coaching;Perception;Policies;Postpartum Period;Postpartum Women;pre-exposure prophylaxis;Pregnancy;Pregnant Women;prenatal;Prevention;preventive intervention;Productivity;programs;Public Health;reproductive;Research;Research Personnel;Research Support;Research Training;Resources;Risk;Risk Assessment;Risk Behaviors;risk perception;Role;Seasons;skills;social factors;Spottings;Study models;Surveys;Tenofovir;Testing;Time;tool;Training;Training Programs;transmission process;United States National Institutes of Health;Woman;Work;Zambia;Zimbabwe

PROJECT_TITLE: A mentoring program for HIV prevention in pregnancy and postpartum

STUDY_SECTION: AIDS

STUDY_SECTION_NAME: Acquired Immunodeficiency Syndrome Research Study Section[AIDS]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: STANFORD

ORG_DEPT: BIOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE This project aims to understand the mechanism of the eukaryotic chaperonin TRiC/CCT, a ring- shaped hetero-oligomeric complex that folds many essential cellular proteins in an ATP- dependent manner. Recent observations have highlighted the links between TRiC and several pathological states incuding cancer, viral infection and neurodegeneration. Thus our project deciphering the mechanism of this chaperonin in cellular folding will help develop therapies to ameliorate these human diseases.

PI_NAMEs: FRYDMAN, JUDITH  (contact)

PROGRAM_OFFICER_NAME: PHILLIPS, ANDRE W

PROJECT_TERMS: Actins;Address;Allosteric Regulation;Apical;ATP Hydrolysis;ATP phosphohydrolase;Binding;Binding Sites;Biochemical;Biological Assay;Biophysics;Cells;chaperonin;Code;cofactor;Complex;Consensus;crosslink;Cryoelectron Microscopy;Data;Encapsulated;Eukaryotic Cell;experimental study;Fluorescence;Fluorescence Spectroscopy;Funding;Genetic;Goals;Heterogeneity;Homo;Human;human disease;Hydrolysis;Individual;insight;Link;Malignant Neoplasms;Mediating;member;Modeling;Molecular;Molecular Chaperones;Molecular Conformation;Mutagenesis;mutant;Mutation;Nerve Degeneration;Nucleotides;parent grant;Pathologic;Pathway interactions;Peptide Library;Peptide Phage Display Library;Play;polypeptide;programs;Property;protein complex;protein folding;Proteins;Recombinants;response;Role;Shapes;Substrate Domain;Substrate Interaction;Surface Plasmon Resonance;System;Testing;therapy development;Time;tool;Variant;Virus Diseases;Work;Yeasts

PROJECT_TITLE: Diversity Supplement under Parent Grant "Mechanism of the Eukaryotic Chaperonin TRiC/CCT"

STUDY_SECTION: MBPP

STUDY_SECTION_NAME: Membrane Biology and Protein Processing Study Section[MBPP]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Coronaviruses;Emerging Infectious Diseases;Infectious Diseases;Influenza;Lung;Pneumonia and Influenza;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE The primary cause of sickness and mortality in respiratory viral infections in humans is often not uncontrolled viral replication, but respiratory distress caused by pro-inflammatory cell infiltration and a loss of epithelial cell resilience and function. An understanding of the baseline host factors present in diverse people is critical to better determine the risk of susceptible populations and novel therapeutic strategies to effectively promote tissue resilience. Importantly, as vaccines for both influenza and SARS-CoV-2 are non-sterilizing, and variants continue to emerge for both, underlying causes of severe viral respiratory diseases will still continue to require adjunctive therapies to complement vaccination campaigns.

PI_NAMEs: ORDOVAS-MONTANES, JOSE MANUEL (contact)

PROGRAM_OFFICER_NAME: LU, QING

PROJECT_TERMS: 2019-nCoV;Airway Disease;airway epithelium;Anabolism;Anti-viral resistance;Anti-viral Response;Area;assault;Basal Cell;Biogenesis;Biology;Cachexia;Cardiovascular system;Cell Physiology;Cell Survival;Cells;cellular resilience;Cholesterol;cholesterol biosynthesis;Clinical;cohort;Complement;Coupled;COVID-19;COVID-19 pandemic;COVID-19 patient;Data;Defect;design;Development;Disease;epidemiology study;Epithelial Cells;epithelial stem cell;Epithelium;Equilibrium;flu;Genes;Genetic study;Glycoproteins;Goblet Cells;Health;Histologic;Host Defense;Host resistance;Human;Immunity;Impairment;in vivo;Individual;Infection;Infiltration;Inflammatory;Influenza;influenza infection;influenzavirus;innovation;Integration Host Factors;Interferons;Investigation;Knowledge;Laboratories;Lead;Light;lipid metabolism;lipidomics;Lipids;Metabolic;Modeling;Molecular;mortality;Mus;Mutation;nasopharyngeal swab;novel;novel therapeutic intervention;obese person;Outcome;Overweight;Oxidoreductase;Pathogenesis;Pathogenicity;Persons;Phenotype;Population;Predisposition;prophylactic;prospective;Publishing;recruit;Regenerative capacity;Research;resilience;Resistance;resistance mechanism;respiratory;Respiratory Disease;Respiratory distress;Respiratory System;respiratory virus;response;Risk;RNA Viruses;screening;seasonal influenza;Secretory Cell;Sensory;severe COVID-19;Severity of illness;Signal Transduction;single-cell RNA sequencing;Specialized Epithelial Cell;stability testing;STAT1 gene;stem cells;Structure of mucous membrane of nose;System;Testing;Therapeutic;Tissues;Up-Regulation;Vaccination;Vaccines;Variant;Viral;Viral Respiratory Tract Infection;Virus;Virus Diseases;Virus Replication;Work;Zinc

PROJECT_TITLE: Balancing epithelial cell resistance and resilience to respiratory viral infections

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Palliative Care;Racial and Ethnic Minority Health Research

PHR: PROJECT NARRATIVE African American (AA) older adults have more than twice the prevalence of Alzheimer’s disease and related dementias (ADRD) compared to non-Latinx White older adults; thus, there are more AA caregivers. Formal care (paid care services for older adults usually associated with a healthcare institution) is essential to the treatment and management of ADRD and associated with better quality of life, and African American adult daughters, the largest group of caregivers of African American persons living with dementia, must navigate decision-making related to formal care. This project seeks to identify key factors associated with the formal care decision-making process for African American persons living with ADRD and to improve the quality of life of African American parent-adult daughter dementia dyads by designing and testing a structured prototype intervention to support these dyads and their families with the formal care decision-making process.

PI_NAMEs: JOHNSON, KALISHA BONDS (contact)

PROGRAM_OFFICER_NAME: RIDDLE, MELISSA

PROJECT_TERMS: Adult Children;Affect;African American;African American population;Alzheimer's disease related dementia;Behavioral;behavioral and social science;care systems;Caregiver research;Caregivers;Caring;Data;Daughter;Decision Making;Dedications;Dementia;Dementia caregivers;dementia caregiving;design;Development;Evaluation;exhaust;experience;Family;feasibility testing;Foundations;Future;health disparity;Health Status;Healthcare;improved;informal caregiving;Institution;Intervention;intervention mapping;Intervention Studies;member;Mentored Patient-Oriented Research Career Development Award;Mentors;Methods;Mission;Modeling;Morbidity - disease rate;multidisciplinary;National Institute on Aging;Not Hispanic or Latino;Nurses;older adult;outcome disparities;Parents;Population Heterogeneity;Prevalence;Process;programs;prototype;Quality of life;racial population;Research;Risk;Scientist;skill acquisition;social culture;Source;Spouse Caregiver;Structure;Testing;therapy design;therapy development;Thinking;Training

PROJECT_TITLE: Designing a Culturally Tailored Formal Care Decision-Making Intervention for African American Dementia Dyads and Families


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Eye Disease and Disorders of Vision;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Regenerative Medicine

PHR: NARRATIVE The Engineered Vision Conference will discuss the fields of bioelectronics, cell-based therapy, and gene therapy. While prioritizing participant diversity, the aim of this meeting is to develop a strategic plan to address grand challenges that cut across these three areas and foster the development of trainees as applied to vision research.

PI_NAMEs: HUMAYUN, MARK S (contact);ZHOU, QIFA

PROGRAM_OFFICER_NAME: ARAJ, HOUMAM H

PROJECT_TERMS: Acceleration;Address;Advanced Development;aged;American;Applications Grants;Area;artificial intelligence algorithm;Augmented Reality;Award;bioelectronics;Biological Testing;Biomedical Engineering;Blindness;career;Cell Therapy;cell type;Cellular Phone;Centers for Disease Control and Prevention (U.S.);Clinical;Collaborations;Communities;Computer software;Contact Lenses;Creativeness;Data;deep learning;Development;Devices;Diagnosis;Disease;Electronics;Engineering;equity, diversity, and inclusion;experience;Eye;fabrication;Faculty;Fostering;Funding;Funding Agency;Future;gene therapy;Glass;Goals;Goggles;Implant;improved;Industrialization;Industry;innovation;interest;Knowledge;Legal Blindness;legally blind;manufacture;meetings;Methodology;Nature;neural network;Neural Retina;next generation;novel;Ophthalmology;Optics;Outcome;outreach;Participant;personalized medicine;Pharmacologic Substance;Physiological;portability;posters;precision medicine;preference;programs;recruit;Regenerative Medicine;Reporting;Research;Research Personnel;Retina;Route;scaffold;Scientific Inquiry;Senior Scientist;stem cells;Strategic Planning;Students;symposium;System;Technology;Therapeutic;Thinking;Time;Tissues;Training;Transfection;Translating;translational potential;translational study;Travel;treatment strategy;ultrasound;United States;virtual reality;Vision;Vision research;vision science;wearable device

PROJECT_TITLE: Engineered Vision Conference (EVC)

STUDY_SECTION_NAME: Special Emphasis Panel[ZEY1 VSN (12)]


NIH_SPENDING_CATS: Bioengineering;Cancer;Cancer Genomics;Digestive Diseases;Genetics;Human Genome;Pancreatic Cancer;Rare Diseases

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: Project Narrative    Pancreatic ductal adenocarcinoma (PDAC) is an aggressive form of pancreatic cancer with limited therapeutic  options.  The  goal  of  this  proposal  is  to  identify  combination  treatment  strategies  that  enhance  existing  PDAC  therapies by chemically degrading or inhibiting key gene- regulatory proteins. This work will guide the deployment  and  development  of  targeted  therapeutics  aimed  at  proteins  responsible  for  drug  resistance  mechanisms  in  PDAC.

PI_NAMEs: NABET, BEHNAM  (contact)

PROGRAM_OFFICER_NAME: SCHMIDT, MICHAEL K

PROJECT_TERMS: Address;Automobile Driving;Biology;Bypass;career development;Career Transition Award;Cell Line;Chemicals;Combined Modality Therapy;Computational Biology;CRISPR screen;Data;design;Development;Disease;Drug resistance;Educational workshop;epigenomic profiling;Evaluation;experimental study;Genes;genetic approach;genetic regulatory protein;Genetic Transcription;genome-wide;Goals;improved;inhibitor;innovation;insight;Interdisciplinary Study;KRAS2 gene;Laboratories;Laboratory Research;Literature;Malignant neoplasm of pancreas;Malignant Neoplasms;MAP Kinase Gene;Measurement;meetings;MEK inhibition;Modeling;mouse model;mutant;Mutate;novel;Oncogenes;Organoids;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;pancreatic ductal adenocarcinoma model;parent grant;Pathway interactions;Patient-Focused Outcomes;Patients;programs;Proteins;Publishing;Regimen;resistance mechanism;Role;Signal Transduction;small molecule;System;targeted treatment;technology platform;Therapeutic;translational model;translational potential;treatment strategy;Work

PROJECT_TITLE: Targeted disruption of the YAP/TAZ/TEAD axis in pancreatic cancer


ADMINISTERING_IC: DK

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Diabetes;Prevention;Wound Healing and Care

ORG_CITY: South Haven

ORG_NAME: EDEN MEDICAL, INC.

ORG_STATE: MN

PHR: Smart Foot Mat Narrative Complications of diabetes that affect the lower extremities are common, complex, and costly. Foot ulceration is the most frequently recognized complication. Recent investigations suggest that 40% of patients experience a recurrent diabetic foot ulcer in the year after healing, and almost 60% within 3 years. Eden Medical is developing a smart foot mat platform to perform daily inspection of their feet to predict ulcer onset and reduce the risk of lower extremity amputation.

PI_NAMEs: ARMSTRONG, DAVID GEORGE;SCHOESS, JEFFREY NORMAN (contact)

PROGRAM_OFFICER_NAME: LI, YAN

PROJECT_TERMS: acceptability and feasibility;Address;Adult;Affect;Agreement;Amputation;Anatomy;Anxiety;Attitude;Biological Markers;Bone callus;Calibration;Cessation of life;Clinical;Clinical Research;Complex;Complication;Complications of Diabetes Mellitus;Confidence Intervals;cost;cost estimate;Coupling;Data;Data Collection;Development;Devices;diabetes management;Diabetes Mellitus;diabetic;Diabetic Foot;Diabetic Foot Ulcer;diabetic patient;diabetic ulcer;Dryness;Early Diagnosis;Enrollment;experience;FDA approved;Feedback;foot;Foot Ulcer;healing;heart rate variability;Hemoglobin;high risk;Home;imaging system;indexing;Infection;Inflammation;Investigation;Lead;Left;Legal patent;Light;Lipids;Liquid substance;Lower Extremity;Maps;Measurement;Measures;Medical;Metabolic Diseases;Methods;Modeling;Monitor;Morphologic artifacts;mortality;mortality risk;Motion;Natural History;Near-Infrared Spectroscopy;Oxygen;Oxygen saturation measurement;Patients;Phase;Physiologic pulse;Pilot Projects;Predictive Value;Preparation;Recurrence;Regional Perfusion;Renal Replacement Therapy;response;Risk;Risk Assessment;Risk Marker;Risk Reduction;ROC Curve;Sample Size;Scanning;sensor;Site;Skin;Skin Pigmentation;Small Business Innovation Research Grant;sobriety;Specificity;Stress;success;Symptoms;System;Technology;Temperature;Testing;Time;tissue phantom;tool;Transducers;treatment planning;Trust;Ulcer;Update;Variant;verification and validation

PROJECT_TITLE: Smart Foot Mat

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 ISB-S (11)]


ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Contact PD/PI: SIMON, MELISSA A. Project Narrative

PI_NAMEs: PERREAULT, ERIC JON;SIMON, MELISSA A. (contact);YANCY, CLYDE W.

PROJECT_TERMS: Equity;recruit;Universities

PROJECT_TITLE: NURTURE: Northwestern University Recruitment to Transform UnderRepresentation and achieve Equity


ORG_CITY: SAN DIEGO

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: SAN DIEGO STATE UNIVERSITY

PHR: Project Narrative San Diego State University (SDSU) is proposing a new faculty recruitment and retention program called SDSU FUERTE (Faculty Unified towards Excellence in Research and Transformational Engagement). Utilizing innovative, evidence-based strategies to promote institutional inclusive excellence, SDSU will recruit nine early-stage, interdisciplinary, tenure-track researchers who have career goals to address Latinx health disparities in the areas of Addiction Science, Environment Health, and Obesity/Physical Activity/Nutrition.

PI_NAMEs: REED, MARK BRIAN;ZUNIGA DE NUNCIO, MARIA LUISA (contact)

PROJECT_TERMS: Academy;addiction;Address;Administrative Supplement;Air;Area;Budgets;career;cohort;Collaborations;Communities;Environment;evidence base;Faculty;Faculty Recruitment;Food;Fostering;Foundations;Funding;Funding Opportunities;Goals;Growth and Development function;Guidelines;Health;health disparity;innovation;Institution;Latinx;meetings;National Cancer Institute;nutrition;Obesity;Physical activity;programs;recruit;Research;Research Personnel;Science;tenure track;Travel;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: SDSU FUERTE: Faculty United towards Excellence in Research and Transformational Engagement


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Mental Health;Prevention;Social Determinants of Health

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: PROJECT NARRATIVE Indigenous GBM in Guatemala experience intersectional stigmas, including racial discrimination, which increase vulnerability to HIV, and other health problems. This study will test the feasibility, acceptability, and preliminary efficacy on HIV and stigma outcomes of a culturally and contextually adapted stigma-reduction intervention for Indigenous GBM and traditional healers in Guatemala. Findings will inform the design of a large effectiveness implementation trial to establish KABAWIL as a model for reducing intersectional stigmas and improve HIV prevention and care for indigenous people in high-stigma, culturally conservative, resource-constrained communities throughout the Americas.

PI_NAMEs: ORELLANA, EDWIN ROBERTO  (contact)

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;AIDS prevention;Americas;Belize;bilingualism;Bisexual;Caring;Characteristics;Cities;Clinics and Hospitals;Consequences of HIV;Consolidated Framework for Implementation Research;Continuity of Patient Care;control trial;Country;Data;design;Discrimination;Dominican Republic;Educational workshop;effectiveness/implementation trial;El Salvador;Ensure;Epidemic;experience;feasibility testing;Feedback;Focus Groups;Future;Gays;Guatemala;Guatemalan;Health;Health Personnel;Health Services;Health system;HIV;HIV Infections;Honduras;Human immunodeficiency virus test;implementation barriers;implementation evaluation;implementation intervention;improved;Indigenous;indigenous community;Individual;Intervention;Interview;Knowledge;Language;Latin America;Latin American;Manuals;men who have sex with men;Mental Health;Mental Health Services;Mesoamerican;Methods;Mexico;Modeling;Names;Outcome;Participant;Patients;Persons;physical conditioning;physical health service;pilot test;Population;post implementation;pre-exposure prophylaxis;prevention service;Process;Provider;psychosocial;Public Health;Public Hospitals;racial discrimination;Randomized;Randomized, Controlled Trials;Recording of previous events;Research;Resource-limited setting;response;sexual minority;sexual minority men;Sexuality;social stigma;Societies;Source;Spanish;Spanish/English;System;Testing;Time;transmission process;trial design;two spirit;uptake;Virus;Waiting Lists

PROJECT_TITLE: Kabawil: Adapting an Intervention to Reduce Intersectional Stigmas among Indigenous Sexual Minority Men and Traditional Healers in Mesoamerica


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);American Indian or Alaska Native;Atherosclerosis;Bioengineering;Biomedical Imaging;Brain Disorders;Cardiovascular;Clinical Research;Dementia;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Physical Activity;Prevention;Racial and Ethnic Minority Health Research

ORG_CITY: ORANGE

ORG_NAME: CHAPMAN UNIVERSITY

PHR: The aim of the proposed administrative supplement is to conduct enhanced computerized tomography (CT) of the brain, mouth/jaw, neck, abdominal aorta, spine, and pelvis by making use of a newly available CT scanner in Bolivia. The new Canon Aquilion Prime SP CT scanner was installed in 2023, and this scanner offers both greater resolution and lower radiation exposure than the original scanner that was previously available. The new scanner will enhance the study of brain aging (Aim 1 of the parent award) with greater differentiation of grey and white matter, regional brain volumes, and intracranial calcifications. Supplemental funds are requested for the increased costs of the enhanced scanning capabilities and to increase imaging coverage to include the abdomen and pelvis, extending the measurement of arteriosclerosis to other arterial beds.

PI_NAMEs: FINCH, CALEB E;GATZ, MARGARET ;GURVEN, MICHAEL DOUGLAS;KAPLAN, HILLARD S (contact);STIEGLITZ, JONATHAN P;THOMAS, GREGORY SCOTT;THOMPSON, RANDALL ;TRUMBLE, BENJAMIN CHAPIN

PROGRAM_OFFICER_NAME: ANDERSON, DALLAS

PROJECT_TERMS: Abdomen;abdominal aorta;Administrative Supplement;Age;aging brain;Apolipoprotein E;Arteries;Arteriosclerosis;Atherosclerosis;Award;Beds;biological sex;Bolivia;Bolivian;Bone Density;Brain;Brain region;brain volume;Budgets;calcification;Cephalic;cerebral atrophy;Cognition;Collaborations;Collection;computerized data processing;Coronary;Coronary artery;cost;Data;Data Analyses;Data Collection;Dementia;Failure;femoral artery;Funding;genotypic sex;German population;Grant;gray matter;Hospitals;iliac artery;Image;Impaired cognition;Infection;Institution;intracranial artery;Jaw;Lesion;Link;Lipids;Measurement;Mechanics;motor impairment;Native American population;Neck;Oral cavity;Outcome;parent project;Parents;Pathway interactions;Pelvis;Phase;Physical activity;Population;Prevalence;Protocols documentation;Radiation Dose Unit;Radiation exposure;Reporting;Research;Resolution;Risk;RNA analysis;Scanning;Schedule;study population;Testing;Thoracic aorta;Travel;Universities;Vertebral column;white matter;X-Ray Computed Tomography

PROJECT_TITLE: Testing Hypothesized Pathways Linking Infection, Physical Activity, Apoe Genotype, And Biological Sex To Low Dementia Prevalence And Reduced Brain Atrophy In Two Native American Populations

STUDY_SECTION: NAME

STUDY_SECTION_NAME: Neurological, Aging and Musculoskeletal Epidemiology Study Section[NAME]


NIH_SPENDING_CATS: Cardiovascular;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: PROJECT NARRATIVE Tyrosine kinase inhibitors (TKIs) are the mainstay therapies for various malignancies; however, several common TKIs are associated with vascular toxicity. In this supplement, we will investigate the underlying mechanisms of TKI-induced vascular toxicity (TKI-VT) by employing iPSC technologies, tissue engineering, and multi-omics, aiding the parent R01 by investigating the impact of TKI on vascular toxicity within Hispanic populations, which will help identify ethnicity-specific pathological mechanisms underlying TKI-VT. The knowledge we gain here will provide novel insights into the pathogenesis of TKI-VT and enable the identification of druggable therapeutics to prevent or treat TKI-VT.

PI_NAMEs: WONG, WING H.;WU, JOSEPH C. (contact)

PROGRAM_OFFICER_NAME: CHARETTE, MARC F

PROJECT_TERMS: 3-Dimensional;Acute Coronary Event;Address;Adhesions;Affect;African American population;Animal Model;Asian population;Biological Assay;Blood capillaries;Blood Vessels;Cancer Patient;Cardiac;Cardiac health;Cardiovascular Diseases;cardiovascular health;cardiovascular risk factor;Cardiovascular system;Caucasians;Cell Density;Cell Physiology;Cell Proliferation;cell type;Cells;Chronic;Circulation;Citrates;Clinical;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;Collagen Type I;Communities;CRISPR screen;Data;Dissociation;druggable target;Endothelial Cells;Endothelium;Environment;ethnic minority population;Ethnic Origin;Ethnic Population;Extracellular Matrix;Face;Force of Gravity;Functional disorder;Funding;Grant;Health;health difference;high risk;Hispanic Populations;Human;human induced pluripotent stem cells;Hydrogels;Hypertension;In Vitro;Individual;induced pluripotent stem cell;induced pluripotent stem cell technology;Inflammation;insight;Journals;Knowledge;Length;Life Expectancy;Malignant Neoplasms;Mediating;Methodology;Methods;migration;Modeling;Molecular;monocyte;monolayer;mortality;multiple omics;Myocardial Infarction;Nature;novel;novel therapeutics;Oncology;Oxidative Stress;Paper;Parents;Pathogenesis;Pathologic;Patients;Pericytes;Peripheral arterial disease;Permeability;Phenotype;Physiological;prevent;Proliferating;Protocols documentation;Publications;Publishing;Qi;racial diversity;recruit;Reporting;Risk;Role;Safety;screening;self assembly;side effect;Signal Pathway;single-cell RNA sequencing;Stroke;Testing;Therapeutic;thrombogenesis;Thrombosis;Tissue Engineering;Toxic effect;transcriptomics;Tyrosine Kinase Inhibitor;United States;vascular contributions;Vascular Diseases;Vascular Endothelial Cell;Whole Blood;Wing

PROJECT_TITLE: Modeling Tyrosine Kinase Inhibitor-Induced Vascular Dysfunction Using Human iPSCs

STUDY_SECTION: BBHV

STUDY_SECTION_NAME: Basic Biology of Blood, Heart and Vasculature Study Section [BBHV]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Dental, Oral, and Craniofacial Disease

ORG_NAME: PERCEPTIVE TECHNOLOGIES, INC.

PHR: PROJECT NARRATIVE Despite the negative consequences of poor dental care, many people do not seek professional services. Cyberdontics is developing a digital imaging platform that will enable faster, more understandable, and more affordable dental diagnoses and treatments. With this Direct to Phase II application, Cyberdontics will refine and test their ultra-fast frame-capture-time 3D swept-source OCT intraoral scanner in preparation for commercialization.

PI_NAMEs: KANG, WEI  (contact)

PROGRAM_OFFICER_NAME: LOPEZ, ORLANDO

PROJECT_TERMS: 3-Dimensional;accurate diagnostics;Air;Algorithms;Alzheimer's Disease;American;Appointment;Artificial Intelligence;base;Biomedical Engineering;care costs;Caring;Clinic;Clinical Research;commercialization;Computer Vision Systems;cone-beam computed tomography;cost;cost effective;Crowns;Data;data acquisition;data analysis pipeline;Dental;Dental Care;Dental caries;Dental Cementum;Dental Clinics;Dental Enamel;Dental Pulp;Dentin;Dentistry;Dentists;Detection;Development;Diabetes Mellitus;Diagnosis;digital imaging;Disease Progression;Effectiveness;Engineering;experience;Exposure to;feasibility testing;Generations;Geometry;Goals;Health;Healthcare;Heart Diseases;human subject;Image;imaging modality;imaging platform;imaging system;Imaging technology;improved;Incidence;Industry;innovation;Insurance Carriers;ionization;Lasers;Mandible;Marketing;Maxilla;Mechanics;Medical;meter;Methods;minimally invasive;Modality;Motion;Noise;novel;Ophthalmology;Optical Coherence Tomography;Oral;Oral health;Patients;Performance;Periodontal Diseases;Persons;Phase;Positioning Attribute;Preparation;prevent;Process;Radiation Dose Unit;radiological imaging;reconstruction;Refractive Indices;Residual state;Resolution;restorative dentistry;retinal imaging;Robotics;Rotation;Saliva;Sampling;Scanning;Services;Signal Transduction;Source;spatial relationship;Speed;Study Subject;Surface;System;Systemic disease;Techniques;Technology;Testing;Therapeutic;Thick;Time;Tissues;Tooth Diseases;Tooth Preparation;Tooth structure;tooth surface;treatment planning;usability;Visit;Visualization;Work

PROJECT_TITLE: Developing an Optical Coherence Tomography (OCT) based handheld intraoral scanner for dentistry

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ISB-Z(10)B]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: NEW YORK

ORG_NAME: VA  MEDICAL CENTER

ORG_STATE: NY

PHR: Background: Tinnitus and hearing loss are among the most common service-connected disabilities with Veterans being at particular risk for severe hearing loss. Comprehensive hearing health services are available within the VA to qualifying veterans. The delivery of optimal hearing healthcare mandates tailored treatments are offered based on degree of hearing loss and patient preferences. These options are defined in practice guidelines including the VA since 2004. Significance/Impact: Despite the prevalence of hearing loss among Veterans, there are few projects studying the management of those with severe hearing loss. Ensuring appropriate treatments for those most severely affected represents an important access to care issue with implications for patients’ communication, quality of life and overall health. This also facilitates patient communication in health care settings as being able to hear is a cornerstone of participation in shared-decision making. Innovation: The VA is the ideal setting to study management of severe hearing loss as this is a prevalent condition among veterans, interested patients are offered comprehensive treatments for hearing loss and longitudinal audiometric data are available to allow identification of factors associated with receipt of particular treatment strategies. Stakeholder engagement including interviews with affected Veterans and providers are incorporated in the study design. Specific Aims: 1. Define the prevalence, modes of treatment and time to treatment of Veterans with severe  hearing loss using the Audiometric Repository, a national database of audiograms and a  registry of assistive listening devices, hearing aids and cochlear implants within the VA,  between 2005-2017. 2. Identify which factors are associated with different treatment approaches for Veterans with  severe hearing loss using the Audiometric Repository linked to administrative data from the  electronic medical record during years 2005-2017. 3. Identify facilitators and barriers for distinct management of severe hearing loss among hearing  aid users (including referral for cochlear implants) through semi-structured interviews with  current VHA providers (audiologists, otolaryngologists and primary care providers) and  affected Veterans. Methodology: A mixed methods study using a sequential explanatory design will be employed. Data from the Audiometric Repository will be linked to administrative data from the electronic health record to understand management of Veterans with severe hearing loss. Interviews will be conducted with various stakeholders including Veterans and providers to identify barriers and facilitators to particular treatment modalities. Next Steps/Implementation: Results from this pilot will provide new information on barriers and facilitators of management of severe hearing loss. In addition to a planned manuscript describing our findings, we will develop educational materials for providers on CI indications and criteria for referral. We will also develop an educational brochure for Veterans and families to address potential attitudinal/knowledge barriers. These materials will form the basis for a Merit application to study trajectories of hearing loss and to develop and test an implementation approach to achieve best practices in the treatment of severe hearing loss.

PI_NAMEs: FRIEDMANN, DAVID R (contact)

PROJECT_TERMS: Acoustics;Address;Adherence;Affect;Age;age related;Age Years;American;Attitude;Audiology;Bilateral;Caring;Clinical Management;clinical practice;Cochlear implant procedure;Cochlear Implants;Communication;comorbidity;Computerized Medical Record;connected health;cooperative study;Counseling;Data;Databases;design;Diabetes Mellitus;disability;Disabling;Education;Educational Materials;Elderly;electronic data;electronic health data;Electronic Health Record;Eligibility Determination;Ensure;Evidence based intervention;Family;functional decline;Geographic Locations;Goals;Guidelines;Health;health care settings;health service use;Health Services;Health Services Accessibility;Healthcare;Hearing;Hearing Aids;hearing impairment;hearing loss treatment;Hearing Tests;Impaired cognition;Improve Access;improved;Individual;individualized medicine;inhibitor;innovation;interest;Intervention;Interview;Knowledge;Link;Literature;Manuscripts;Medical;Mental Depression;Methodology;Methods;military service;Modality;Neurocognitive Deficit;noise exposure;Otolaryngologist;Outcome;Outpatients;Pamphlets;Patient Preferences;patient subsets;Patients;Personal Satisfaction;Practice Guidelines;Prevalence;prevent;primary care provider;Procedures;Process;programs;prospective;Prosthesis;Provider;provider factors;Psyche structure;Qualifying;Quality of Care;Quality of life;Recommendation;Registries;Rehabilitation therapy;repository;Research Design;Research Methodology;research study;Risk;Schedule;Services;shared decision making;Social isolation;sociodemographic variables;sound;Specialist;Structure;System;systematic review;Testing;Time;Tinnitus;treatment strategy;United States Agency for Healthcare Research and Quality;Update;verbal;Veterans;Veterans Health Administration;Work

PROJECT_TITLE: Resubmssion: Management of Severe Hearing Loss in the Veterans Health Administration

STUDY_SECTION_NAME: HSR-1 Health Care and Clinical Management[HSR1]


ADMINISTERING_IC: OD

FUNDING_MECHANISM: CONSTRUCTION GRANTS

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: HIV/AIDS

ORG_CITY: SAN JUAN

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF PUERTO RICO MED SCIENCES

ORG_STATE: PR

PI_NAMEs: SARIOL, CARLOS A (contact)

PROGRAM_OFFICER_NAME: SPECTOR, JEFFREY O

PROJECT_TERMS: Animals;Biomedical Research;Breeding;Communities;Funding;HIV/AIDS;Macaca mulatta;Modeling;National Institute of Allergy and Infectious Disease;nonhuman primate;programs;Research;Research Personnel;Resources;Therapeutic Intervention;United States National Institutes of Health;vaccine development

PROJECT_TITLE: Expansion of an established breeding SPF Program at CPRC

STUDY_SECTION: STOD

STUDY_SECTION_NAME: Scientific and Technical Review Board on Biomedical and Behavioral Research Facilities[STOD]


ORG_CITY: LANCASTER

ORG_NAME: SIMULATIONS PLUS, INC.

PHR: Identifying chemicals with similar shape and characteristics to other chemicals that bind a drug target has proven useful in several areas of drug discovery and development. While there are several programs that currently do this, none account for water molecules that make important connections between the drug and the target. We aim to create software that includes these relevant water molecules into the shape-matching calculations, thereby improving upon current programs and leading to better, faster, and more effective new drugs.

PI_NAMEs: JONES, JEREMY O (contact)

PROGRAM_OFFICER_NAME: KODURI, SAILAJA

PROJECT_TERMS: 3-Dimensional;Algorithms;aqueous;Area;Binding;Binding Sites;Biological Assay;Characteristics;chemical binding;chemical group;Chemicals;Chemistry;Code;Collection;Complex;Computer software;conformer;design;Drug Design;drug development;drug discovery;Drug Industry;Drug Kinetics;Drug Targeting;Environment;Evolution;Excision;Exclusion;experimental study;Generations;Glucose;Glyburide;Goals;Hybrids;Hydrogen Bonding;improved;in vitro activity;in vitro testing;in vivo;insulin secretion;Ligand Binding;Ligand Binding Domain;Ligands;Machine Learning;Methodology;Methods;novel;novel strategies;novel therapeutics;Pharmaceutical Preparations;pharmacologic;pharmacophore;Play;Positioning Attribute;prevent;programs;Property;prospective test;Proteins;Research Personnel;Role;scaffold;Scoring Method;screening;Shapes;simulation;Structure;Sulfonylurea Compounds;Techniques;Test Result;three dimensional structure;Tolbutamide;Toxic effect;virtual;virtual library;virtual screening;Water;Work;Writing

PROJECT_TITLE: Improving Similarity Scoring in Drug Discovery: Solving by Solvating

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MBBC-G (10)]


ORG_CITY: CHAMPAIGN

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

PHR: PI: BLANKE, S.R.  NIAID R13 Application  Lakeside Conference on Protein Toxins and Effectors PROJECT NARRATIVE This application requests support for the “Lakeside Conference on Protein Toxins and Effectors”, to be held October 6-9, 2024 at the Abbey Resort and Conference Center, located on the shores Lake Geneva Wisconsin, USA, which will focus on the cellular, structural, and biochemical mechanisms of protein toxins and effectors, as well as translational efforts to leverage this research for the mitigation and treatment of disease. Goals of the conference are (i) to provide an inclusive environment for bringing together existing communities of microbiologists, biochemists, structural biologists, and biophysicists in North America who share an interest and passion for protein toxin/effector biology, (ii) to promote new collaborations across disease and phylogenetic boundaries, and, (iii) to provide professional and career opportunities for trainees, early career scientists, including those individuals who identify as historically unrepresented minorities. Importantly, the “in person-virtual” hybrid format of the conference is intended to promote both diversity and the highest level of inclusion for scientists and their laboratory teams who are unable to attend the meeting in person.

PI_NAMEs: BLANKE, STEVEN R. (contact)

PROGRAM_OFFICER_NAME: MULACH, BARBARA L

PROJECT_TERMS: Address;anthrax toxin;Area;Award;Bacteria;Bacterial Proteins;Biochemical;Biology;Botulinum Toxins;Caliber;career;Cells;Characteristics;Cholera Toxin;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Communities;Complex;Cryoelectron Microscopy;cytotoxic;design;Detection;Diphtheria Toxin;Discipline;Disease;Disease Progression;Ecosystem;Environment;Eukaryotic Cell;Family;Feedback;Fees;follow-up;Fostering;Funding;Future;Goals;graduate student;human disease;Hybrids;Illinois;Individual;Injections;innovation;insight;interdisciplinary collaboration;interest;Investigation;Knowledge;Laboratories;live stream;medical schools;meetings;member;Methods;microbial community;microbial genomics;Microscopy;Minority;Modality;Modeling;multidisciplinary;National Institute of Allergy and Infectious Disease;North America;novel;Oral;Participant;Pathogenesis;pathogenic bacteria;Persons;Phylogenetic Analysis;Postdoctoral Fellow;posters;programs;Protein Family;Protein Secretion;Proteins;Proteomics;Request for Applications;Research;Research Personnel;Resolution;Resort;Running;Scholarship;Science;Scientist;screening;Secure;Services;Shapes;single molecule;Structural Biologist;structural biology;Structure;Students;symposium;Syringes;System;Techniques;Technology;Testing;tool;Toxin;translational potential;Translations;Travel;Type III Secretion System Pathway;Type IV Secretion System Pathway;Underrepresented Minority;United States National Institutes of Health;Universities;Videoconferencing;virtual;Virulence Factors;Wisconsin;Woman;Work

PROJECT_TITLE: 2024 Lakeside Conference on Protein Toxins and Effectors

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 CAB-D (M1)]


ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PI_NAMEs: KAPER, JAMES B (contact);LACOURSE, WILLIAM RICHARD

PROGRAM_OFFICER_NAME: CALZOLA, JESSICA MARIE

PROJECT_TERMS: Academy;Affect;Appointment;Area;Baltimore;Cancer Biology;cohort;Communicable Diseases;Communities;County;Dedications;Educational process of instructing;Ensure;Environment;experience;Faculty;faculty mentor;Funding;Goals;Grant;Individual;Infrastructure;Institution;Institutional Policy;Link;Maryland;medical schools;member;Microbiology;Modeling;Neurosciences;Procedures;programs;recruit;Research;Resources;Schools;Services;Teacher Professional Development;tenure track;Textiles;undergraduate student;Underrepresented Minority;Underrepresented Populations;United States National Institutes of Health;Universities

PROJECT_TITLE: University of Maryland FIRST Program


NIH_SPENDING_CATS: Microbiome;Nutrition;Physical Activity

ORG_NAME: JOSLIN DIABETES CENTER

PHR: PROJECT NARRATIVE This project will determine how gut bacteria, known as the gut microbiome, can influence the health benefits of regular physical exercise. We will test whether specific types of gut bacteria can act in conjunction with exercise training to enhance improvements in metabolic health in mouse models of disease with high blood sugar levels. We anticipate this work will lead to development of a “probiotic” treatment to improve health and the response to exercise training in people with metabolic diseases like type 1 and type 2 diabetes.

PI_NAMEs: KOSTIC, ALEKSANDAR DAVID (contact);LESSARD, SARAH

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Aerobic;Bacteria;Biological Response Modifier Therapy;Blood Glucose;Defect;Development;disease model;Exercise;exercise intensity;exercise training;Fermentation;glucose metabolism;gut bacteria;gut microbes;gut microbiome;Health;Health Benefit;impaired glucose tolerance;Impairment;improved;Individual;insulin sensitivity;Lead;Mediator;Metabolic;Metabolic Diseases;Metabolism;microbial;Microbiology;microbiome;mouse model;Muscle;Muscle function;muscle metabolism;novel;Pathology;Performance;Persons;Physical Exercise;probiotic therapy;Production;receptor;response;Skeletal Muscle;skeletal muscle metabolism;Source;Supplementation;Testing;Tissues;Training;type I and type II diabetes;Volatile Fatty Acids;Work

PROJECT_TITLE: Gut microbial fermentation products of muscle-derived lactate as mediators of exercise and metabolism

STUDY_SECTION: CSME

STUDY_SECTION_NAME: Cell Signaling and Molecular Endocrinology Study Section[CSME]


ED_INST_TYPE: OVERALL MEDICAL

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Emerging Infectious Diseases;HIV/AIDS;Immunization;Immunotherapy;Infectious Diseases;Nanotechnology;Orphan Drug;Prevention;Rare Diseases;Vaccine Related

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: NARRATIVE Individuals with an underlying HIV-infection have an increased risk of developing AIDS-related malignancies. Kaposi sarcoma-associated herpesvirus (KSHV) is the necessary causal agent for Kaposi's sarcoma and is a cofactor in B cell lymphoproliferative disorders observed in AIDS patients. Devising a vaccine strategy that can inhibit KSHV infection amongst the population is a necessary first step in creating a vaccine to prevent the spread of KSHV worldwide and the results from the proposed studies utilizing the nonhuman primate model should help elucidate and define vaccine strategies to prevent KSHV infection or KSHV-associated disease.

PI_NAMEs: WONG, SCOTT W (contact)

PROGRAM_OFFICER_NAME: READ-CONNOLE, ELIZABETH LEE

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;acute infection;Agonist;AIDS related cancer;Animals;Antibodies;antibody-dependent cell cytotoxicity;antibody-dependent cellular phagocytosis;Antigen-Presenting Cells;antigen-specific T cells;Antigens;B-Lymphocytes;Binding;Biological Sciences;Biotechnology;Cell Lineage;cell type;Cells;Chimera organism;Chimeric Proteins;cofactor;Collaborations;Complement-Dependent Cytotoxicity;Complex;Data;Dendritic Cells;Development;Disease;Dose;General Population;Glycoproteins;Goals;head-to-head comparison;Herpesviridae Infections;Herpesvirus Vaccines;HIV Infections;Human;Human Herpesvirus 8;Immune;Immune response;Immunization;Immunize;Immunocompetent;Immunoglobulin G;Immunologic Stimulation;Immunosuppression;In Vitro;in vivo;Individual;Infection;innovation;Kaposi Sarcoma;latent infection;Laws;lipid nanoparticle;Lymphoproliferative Disorders;Macaca mulatta;Mediating;Messenger RNA;Modeling;monocyte;mRNA lipid nano particle vaccine;nonhuman primate;novel;novel vaccines;Oral;Patients;Peripheral Blood Mononuclear Cell;Population;prevent;Primates;Principal Investigator;Production;Proteins;Reagent;Recombinant Fusion Proteins;recombinant virus;Recombinants;research clinical testing;Research Personnel;response;Rhadinovirus;Rhesus;Risk;Rodent;Safety;SARS-CoV-2 immunity;SIV;Study Section;therapeutic vaccine;Time;Toll-like receptors;transmission process;Vaccinated;Vaccination;vaccination strategy;vaccine platform;vaccine strategy;Vaccines;Viral Antigens;Virus;Virus Diseases

PROJECT_TITLE: Targeting CD180 to induce anti-KSHV response in nonhuman primates

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-A (M2)]


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Emerging Infectious Diseases;HIV/AIDS;Immunization;Infectious Diseases;Prevention;Rare Diseases;Vaccine Related

PHR: PROJECT NARRATIVE Kaposi Sarcoma-associated herpesvirus (KSHV) is an important pathogen that drives tumor formation, particularly in persons living with HIV-1/AIDS. The research proposed herein aims to understand the role that antibodies play in preventing KSHV infection and or tumor development. This work could lead to the development of a protective vaccine that eliminates the burden of KSHV-driven malignancies worldwide.

PI_NAMEs: BOONYARATANAKORNKIT, JIM ;MCGUIRE, ANDREW  (contact);PHIPPS, WARREN

PROGRAM_OFFICER_NAME: LIDDELL HUPPI, REBECCA

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Africa South of the Sahara;Animal Model;Animals;Antibodies;Antibody Response;Antibody-mediated protection;Antigens;B-Lymphocytes;Binding;Biological Assay;Cell Line;Cell Separation;cell type;Cells;Childhood;cohort;Complex;Cryoelectron Microscopy;design;Development;Disease;efficacy evaluation;Epitopes;General Population;Genetic Complementation Test;glycoprotein structure;Glycoproteins;Herpesviridae Infections;Herpesvirus Vaccines;HIV;HIV-1;Human;Human Herpesvirus 8;humanized mouse;Humoral Immunities;Immune response;Immunotherapy;In Vitro;in vivo;Individual;Infection;Infection prevention;Kaposi Sarcoma;Ligands;Malignant Neoplasms;men who have sex with men;Modeling;Monoclonal Antibodies;Morbidity - disease rate;mortality;mouse model;Multicentric Angiofollicular Lymphoid Hyperplasia;neutralizing antibody;neutralizing monoclonal antibodies;Oncogenic Viruses;Participant;pathogen;Pathway interactions;Peripheral Blood Mononuclear Cell;Persons;Plasma;Play;prevent;primary effusion lymphoma;Process;prophylactic;rational design;receptor;Recombinants;Reporter;repository;Research;response;Role;Sampling;seropositive;Serum;Site;Structure;Therapeutic;tool;tumor;Uganda;Vaccine Design;vaccine development;vaccine response;Vaccines;Viral;Viral Physiology;Viral Proteins;Virus;Work;X-Ray Crystallography

PROJECT_TITLE: Defining Critical Sites of Vulnerability and Correlates of Protection to Kaposi Sarcoma Associated Herpesvirus to Inform Vaccine Design


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Aging;Osteoporosis;Patient Safety;Physical Injury - Accidents and Adverse Effects;Prevention

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative Our project, which includes data from three large, population-based studies of AFF, will help identify people at particularly high or low risk for AFF, facilitating the development of prediction models and risk score tools. Three other projects with diverse sets of aims and methodologies using combinations of claims and electronic health records data were also funded through the same program announcement to advance the research program. The goal of this administrative supplement is to fund the effort required to support the coordination and collaboration of a consortium consisting of the four R01-funded projects that are leveraging existing large databases and cohorts to better understand the risks and benefits of long-term osteoporosis therapy and drug holiday.

PI_NAMEs: ADAMS, ANNETTE L;BLACK, DENNIS M (contact)

PROGRAM_OFFICER_NAME: CHEN, FAYE H

PROJECT_TERMS: Address;adjudication;Administrative Supplement;Aging;Algorithms;American;Benefits and Risks;Biometry;bisphosphonate;Black race;bone;clinical practice;clinical risk;Clinical Trials;Code;cohort;Cohort Studies;Collaborations;Communication;computable phenotypes;Coordination and Collaboration;Data;data harmonization;Data Set;Databases;Decision Making;Development;Electronic Health Record;Endocrinology;Epidemiology;Equilibrium;experience;Femoral Fractures;Fracture;fracture risk;Fright;Funding;Geriatrics;Goals;Grant;high risk;Hip Fractures;Holidays;Individual;individual patient;Industry;Lead;meetings;member;Methodology;Methods;Minerals;Mission;Modeling;Morbidity - disease rate;mortality;Multicenter Studies;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;NIH Program Announcements;Orthopedics;Osteoporosis;osteoporosis with pathological fracture;Outcome;parent grant;Patients;Pattern;Periodicals;Persons;Pharmaceutical Preparations;pharmacologic;Pharmacology;Physicians;population based;Population Study;predictive modeling;Prevention;Principal Investigator;programs;Provider;Public Health;Qualifying;radiological imaging;Recommendation;repository;Research;Research Support;Risk;Risk Factors;risk prediction;Schedule;Science;secondary analysis;Societies;Specific qualifier value;Spinal Fractures;Statistical Methods;Supervision;tool;treatment duration;United States National Institutes of Health;webinar;working group

PROJECT_TITLE: Coordination of Consortium Activities for RFA-AG-22-018


NIH_SPENDING_CATS: Bioengineering

ORG_CITY: ATHENS

ORG_NAME: UNIVERSITY OF GEORGIA

PHR: Project Narrative Metabolism is the process by which food is converted into energy and the molecular building blocks necessary for life. It is highly dynamic and changes rapidly with different conditions, for example after a large meal or vigorous exercise. We can measure a great number of metabolites in chemical extracts or biofluids, but there are few methods to measure metabolites in living systems. This project is to develop a better method to measure metabolism in a living microorganism in different conditions.

PI_NAMEs: EDISON, ARTHUR S (contact)

PROGRAM_OFFICER_NAME: BARNES, CHARLES ASHLEY

PROJECT_TITLE: Platform for in vivo Metabolism

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

ORG_CITY: WOODCLIFF LAKE

ORG_NAME: DIRECTSEQ BIOSCIENCES, INC.

ORG_STATE: NJ

PHR: Current technologies can sequence only a subset of RNA sequences and modifications, not their entirety. The goal of the proposed research is to test feasibility of next-generation mass spectrometry-based exhaustive sequencing to deliver a comprehensive profile of RNAs and their modifications, a crucial advance for understanding their impact on human health.

PI_NAMEs: ZHANG, SHENGLONG  (contact)

PROGRAM_OFFICER_NAME: NOVA, IAN CURTIS

PROJECT_TERMS: Acids;Address;Affect;Algorithms;American;analytical method;anti-cancer research;Benchmarking;Biological Sciences;Cancer cell line;Chemicals;Complementary DNA;Complex;Data;Defect;Detection;Disease;drug development;Ensure;Enzymes;Face;feasibility testing;Genomics;Goals;Health;Heterogeneity;High-Throughput Nucleotide Sequencing;Human;human disease;Hydrolysis;Industry;innovation;insight;Legal patent;Length;Libraries;Ligation;Link;Location;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant Neoplasms;Maps;Mass Spectrum Analysis;MEL Gene;Melanoma;Methods;Modification;nanopore;Nature;neglect;next generation;next generation sequencing;Nucleotides;Pharmaceutical Preparations;Phenylalanine-Specific tRNA;Play;Preparation;Process;Research;Research Personnel;RNA;RNA Degradation;RNA Sequences;Role;Sampling;Services;Site;Skin Cancer;Specificity;stoichiometry;Techniques;Technology;Testing;Therapeutic;therapeutic RNA;Time;transcriptome sequencing;Transfer RNA;tumor progression;two-dimensional;Variant;Yeasts

PROJECT_TITLE: Exhaustive de novo sequencing of every RNA in a sample by a layer-by-layer mass spectrometry ladder intensity approach.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-J (10)]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences;Social Determinants of Health

ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: Project Narrative Acoustic communication is at the center of our everyday lives and impedances on it directly affect our well- being. The results of my proposed research will bridge a critical gap in our understanding of the neural mechanisms mediating the auditory processing of social sounds in mammals and will pave the way to new predictions and hypotheses on speech and natural sound processing mechanisms in humans. By leveraging bats as auditory specialist animal models, the project will yield new discoveries on sound processing, which is a necessary first step towards therapeutic interventions for individuals for whom auditory processing may be challenging.

PI_NAMEs: SALLES, ANGELES  (contact)

PROGRAM_OFFICER_NAME: POREMBA, AMY

PROJECT_TITLE: Neural processing of communication sounds: acoustic features and semantic content

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Microbiome;Neurodegenerative;Neurosciences

ORG_CITY: WORCESTER

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: PROJECT NARRATIVE Alzheimer's disease (AD) is the most frequent causes of dementia of which there is no cure and treatment options are limited. Recently the human gut microbiome, the community of microorganisms that live within our intestines, has been connected to several neurodegenerative disorders, however this research among AD elders has been limited. Accordingly, our goal is to compare the microbiome of older adults with AD to those without dementia, and to categorize them by peripheral AD biomarkers, to determine the role the microbiome plays in cognitive decline while studying local and systemic immune function and brain cellular activity. Understanding how the intestinal microbiome impacts AD development and progression will provide novel therapeutic targets and enable future trials aimed at improving the memory of patients with AD.

PI_NAMEs: HARAN, JOHN PATRICK (contact)

PROGRAM_OFFICER_NAME: ARUNKUMAR, NANDINI

PROJECT_TERMS: Alzheimer's Disease;Alzheimer's disease patient;Alzheimer’s disease biomarker;amnestic mild cognitive impairment;Amyloid beta-Protein;Apolipoprotein E;Back;Biological;Biological Assay;Biological Markers;Blood;Brain;Categories;Characteristics;Clinical assessments;clinical diagnosis;Cognition;Cognitive;cognitive testing;cohort;Communities;cytokine;Data;Dementia;Development;dysbiosis;Elderly;Epithelium;Etiology;Feces;Functional disorder;Funding;Future;gene function;Goals;gut inflammation;gut microbiome;gut-brain axis;Human;immune function;immunosenescence;Impaired cognition;improved;in vivo;Inflammation;inflammatory marker;insight;Intestines;Light;Measures;Memory;Metabolic;metabolomics;microbiome;microbiome composition;microbiome research;microbiota;microbiota-gut-brain axis;Microglia;microorganism;mild cognitive impairment;Movement;National Institute on Alcohol Abuse and Alcoholism;Neurodegenerative Disorders;neurofilament;new therapeutic target;older adult;Participant;Pathologic;Pathology;Peptides;Peripheral;peripheral blood;Play;Population;Positron-Emission Tomography;Research;Research Support;Role;Sampling;stool sample;systemic inflammatory response;T-Lymphocyte;tau-1;Taxonomy;Time;Work

PROJECT_TITLE: Understanding the “Microbiome-gut-brain axis” in Alzheimer’s disease and its Role in Cognitive Decline

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(55)-R]


NIH_SPENDING_CATS: Biotechnology;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Gene Therapy;Genetics;Liver Disease;Lung;Neurosciences;Orphan Drug;Pediatric;Rare Diseases

ORG_CITY: DURHAM

ORG_DEPT: PEDIATRICS

ORG_NAME: DUKE UNIVERSITY

PHR: PROJECT NARRATIVE  Pompe disease is a devastating disease that affects the heart, muscles, and breathing, particularly in infants. In this project we will use a Pompe disease mouse model to test how novel therapies are able to clear the accumulated glycogen which is a classic sign of this disease. Once glycogen is cleared, we will analyze the organelles responsible for nutrient recycling, which become nonfunctional and lead to breathing problems caused by neural and muscle weakness in Pompe disease.

PI_NAMEs: ROGER, ANGELA L. (contact)

PROGRAM_OFFICER_NAME: LACHOWICZ-SCROGGINS, MARRAH ELIZABETH

PROJECT_TERMS: Acute;Address;adeno-associated viral vector;Affect;Architecture;Automobile Driving;Autophagocytosis;Autophagosome;Blood;blood-brain barrier crossing;Brain;Breathing;Cardiac;career;Cell Therapy;Childhood;Clinical;clinical care;Clinical Treatment;Clinical Trials;Collaborations;Complex;Disease;Distress;Environment;enzyme deficiency;enzyme replacement therapy;Enzymes;experience;experimental study;FDA approved;Foundations;FRAP1 gene;Functional disorder;Future;gallium arsenide;Gene Delivery;gene replacement;gene therapy;Genes;Glucan 1,4-alpha-Glucosidase;Glycogen;Glycogen Storage Disease;Glycogen storage disease type II;Goals;Health;Heart;Heart Hypertrophy;Human;Hypoxia;Immune response;Immunohistochemistry;Immunosuppressive Agents;improved;infancy;Infant;innovation;Intervention;Knowledge;Lead;Location;Lysosomes;Mentors;Metabolic;Methods;Molecular;Motor;Motor Neurons;motor recovery;mouse model;Mus;Muscle;Muscle function;Muscle Weakness;Mutation;Myocardium;Nerve;neural;Neurobiology;Neuromuscular Diseases;Neuronal Plasticity;neurophysiology;novel;novel therapeutics;Nutrient;Organelles;Output;Pathology;Pathway interactions;Patient Care;Patients;Phase;preservation;prevent;Process;Proteins;Proteomics;Recombinant adeno-associated virus (rAAV);Recombinants;Recycling;repaired;Research;Research Personnel;Respiration;respiratory;respiratory disease/disorder therapy;Respiratory distress;Respiratory Failure;Respiratory Muscles;Respiratory physiology;Respiratory Therapy;Scientist;Secondary to;Sirolimus;skeletal;Skeletal Muscle;skills;standard of care;targeted treatment;Testing;Therapeutic;Translating;Universities;Viral Genes;Whole Body Plethysmography;Work

PROJECT_TITLE: Novel Adjunctive Therapies for Pompe Disease

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Depression;Major Depressive Disorder;Mental Health;Mental Illness;Serious Mental Illness

ORG_CITY: SALT LAKE CITY

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Project Narrative Not applicable This is an administrative supplement to R33 AT012329-01 Rapaport (PI) 04/11/2023 – 03/31/2026 Specialized pro-resolving lipid mediators and treatment resistant depression

PI_NAMEs: RAPAPORT, MARK HYMAN (contact)

PROGRAM_OFFICER_NAME: CHIDEYA-CHIHOTA, SEKAI RUTENDO

PROJECT_TERMS: Administrative Supplement;lipid mediator;treatment-resistant depression


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Diabetes;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Microbiome;Neurosciences;Nutrition;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_NAME: NEW YORK UNIVERSITY

PHR: NARRATIVE Black and Hispanic women (BHW) are disproportionately affected by poverty, type 2 diabetes, HIV, and depression, but the social and biological pathways that promote and facilitate the intersection of these epidemics are unclear, a deficit that limits our understanding of health disparities etiology and, in turn, hampers the development of effective strategies to improve health and health equity. The proposed research will use an intersectional and multi-omic approach (epigenetics, gut microbiome) to elucidate how experiences of poverty translate to biological maladaptation and examine effects on mental and metabolic health and variation by race and ethnicity. The goal of this project is to fill critical scientific gaps about the biological embodiment of poverty and pathways through which risk and protective factors operate and, ultimately, inform future research and strategies to eradicate health disparities and improve health equity for BHW.

PI_NAMEs: PEREZ, NICOLE BEAULIEU (contact)

PROGRAM_OFFICER_NAME: GARRIDO, CARLOS OSWALDO

PROJECT_TERMS: accelerated epigenetic aging;Acceleration;Affect;Aging;Behavioral;Bioinformatics;Biological;Biological Markers;Biology;black women;brain based;built environment;Caring;Clinical;Clinical Data;cohort;Cohort Studies;Collection;Communities;comorbidity;Critical Pathways;Cross-Sectional Studies;Data;Data Collection;depressive symptoms;design;Development;Diagnosis;diagnostic biomarker;disparity reduction;Disproportionately impacts women;Economics;Environmental Impact;Environmental Risk Factor;Epidemic;epigenetic aging;Epigenetic Process;Ethnic Origin;Etiology;experience;Exposure to;food insecurity;Functional Magnetic Resonance Imaging;Funding;Future;Glycosylated hemoglobin A;Goals;Grant;gut microbes;gut microbiome;gut-brain axis;Health;health disparity;health equity;Heterogeneity;Hispanic Women;HIV;HIV Seropositivity;improved;indexing;Individual;Inequity;inflammatory marker;K-Series Research Career Programs;Link;Low income;low socioeconomic status;Maps;Mental Depression;Mental Health;Mentors;Metabolic;Metabolic dysfunction;Methods;microbiome;microbiome alteration;Molecular;multiple chronic conditions;multiple omics;National Institute of Mental Health;National Institute on Minority Health and Health Disparities;Neurobiology;neuroimaging;Non-Insulin-Dependent Diabetes Mellitus;nutrition;Outcome;Pathway interactions;Poverty;programs;protective factors;Psyche structure;Race;Research;Risk;Risk Factors;Role;Sentinel;Severities;social;social culture;social factors;socioeconomic disadvantage;socioeconomics;Stress;Symptoms;syndemic;The Multicenter AIDS Cohort Study;Training;Translating;United States;United States National Institutes of Health;Variant;Woman;Women's cohort;Women's Interagency HIV Study;Work

PROJECT_TITLE: Reducing Disparities in Mental and Metabolic Health among Predominantly Low-Income, Black and Hispanic Women with and without HIV

STUDY_SECTION_NAME: Special Emphasis Panel[ZMD1 DRI (M2)]


ORG_CITY: Columbus

ORG_DEPT: PHYSIOLOGY

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative Heart failure is the most frequent cause of death in the developed world and often identified by significant enlargement of the heart called hypertrophy. This hypertrophy is divided into early, adaptive and chronic, disease causing stages with little knowledge to the mechanisms which regulate this transition over time. This study proposes to identify those mechanisms and therapeutically promote the persistence of adaptive hypertrophy which associates with significantly greater heart performance.

PI_NAMEs: NASSAL, DREW  (contact)

PROGRAM_OFFICER_NAME: TJURMINA, OLGA A

PROJECT_TERMS: acute stress;Aortic Valve Stenosis;Area;Automobile Driving;betaIV spectrin;Cardiac;Cardiac Myocytes;Cardiac Output;Cardiomegaly;Cardiovascular system;career;career development;Cause of Death;Cells;ChIP-seq;Chronic;Chronic stress;Clinical;Complex;Cytoskeletal Proteins;Data;design;Development;Dimensions;Disease;Disease Progression;DNA Binding;effectiveness evaluation;Fibrosis;Framingham Heart Study;Future;gene induction;Gene Targeting;gene therapy;Genes;Genetic;Genetic Transcription;Grant;Growth;Heart;Heart Diseases;Heart failure;heart function;Heart Hypertrophy;heart preservation;Human;Hypertrophy;Immune signaling;improved;in vivo;Incidence;Individual;Inflammation;insight;Intervention;Investigation;Knowledge;Left;Left Ventricular Hypertrophy;Length;Link;Malignant Neoplasms;MAPK3 gene;Mediating;Mentorship;Microtubule Proteins;Microtubules;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;Muscle Cells;Myocardial;Myocardial Infarction;Nature;novel;novel therapeutic intervention;novel therapeutics;oral communication;Organ;Organism;Outcome;Pathologic;Pathway interactions;Performance;pharmacologic;Phosphorylation;preservation;pressure;prevent;Prevention;programs;recruit;Regulation;Reporting;Research;Resistance;response;Risk Factors;Role;Scientist;Serine;Signal Transduction;skills;Source;Spectrin;Stat3 protein;Stimulus;Stress;stressor;Switch Genes;targeted agent;Testing;Therapeutic;therapeutic evaluation;therapeutic target;Thinness;Time;Tissues;transcription factor;transcriptome sequencing;translational study;Treatment Failure;Universities;Ventricular;Width;Work;Writing

PROJECT_TITLE: Regulation of STAT3 phosphorylation and its role in orienting myocyte hypertrophy


NIH_SPENDING_CATS: Infectious Diseases;Lung;Orphan Drug;Rare Diseases

ORG_CITY: DIX HILLS

ORG_NAME: MICRORID TECHNOLOGIES, INC.

PHR: NARRATIVE Fungal infections have dramatically increased during the last decade and new treatment strategies are needed. This proposal focuses on developing new compounds targeting selectively the fungal ceramide synthases.

PI_NAMEs: DEL POETA, MAURIZIO  (contact)

PROGRAM_OFFICER_NAME: LIU, BAOYING

PROJECT_TERMS: A549;Acquired Immunodeficiency Syndrome;Animal Model;Animals;anti-fungal agents;Aspergillosis;Asthma;ATP phosphohydrolase;Attention;Biochemical;Biological Availability;Blood;Candidiasis;Carbon Dioxide;Cell membrane;Ceramides;Cryptococcosis;Data;Death Rate;Development;dihydroceramide desaturase;Disease;Disseminated candidiasis;Dose;Drug Design;Engineering;Environment;Enzymes;experience;fungicide;fungus;Glucosylceramides;Goals;Growth;Healthcare;HepG2;high throughput screening;Hospitals;Human;Immunocompromised Host;improved;in vitro Assay;in vivo;Incidence;indexing;Industry;Infection;Inflammatory;Inhalation;inhibitor;Lead;Libraries;Life;Lung;Malaria;Mammalian Cell;Mammals;Modeling;mutant;Mycoses;novel therapeutic intervention;novel therapeutics;Organ;pathogenic fungus;Patient-Focused Outcomes;Patients;Persons;Pharmaceutical Chemistry;Physiological;Plants;preclinical study;Production;Property;Regulation;Reporting;research and development;screening;Sepsis;Sphingolipids;Testing;theories;Therapeutic;Tissues;Toxicity Tests;Treatment outcome;Tuberculosis

PROJECT_TITLE: Targeting fungal ceramide synthases as new antifungals

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 DCAI-F (12)]


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Networking and Information Technology R&D (NITRD);Social Determinants of Health

ORG_CITY: SAINT PAUL

ORG_NAME: XANTHOSHEALTH, INC.

PHR: NARRATIVE ConnectedNest, developed by XanthosHealth using SBIR Phase I funding from NIH, addresses the critical issue of social determinants of health (SDoH) affecting individuals facing cancer, aiming to reduce health inequities and adverse outcomes. Through a pilot study in Minneapolis, the platform demonstrated successful engagement with community-based organizations (CBOs) and cancer survivors. In Phase II, the project aims to enhance ConnectedNest's technical features, and conduct a randomized clinical trial recruiting patients from multiple oncology clinics to evaluate its impact on patient health outcomes, with the ultimate goal of providing an innovative, cost-effective, and scalable solution to connect individuals with essential social and community services in the context of cancer care and beyond.

PI_NAMEs: HAYNES, DAVID A (contact)

PROGRAM_OFFICER_NAME: DJEMIL, SARRA

PROJECT_TERMS: Accident and Emergency department;Address;Adopted;Adult;Adverse effects;adverse outcome;Affect;Algorithms;application programming interface;Appointment;Architecture;Area;Award;Businesses;cancer care;Cancer Survivor;Cancer Survivorship;cancer therapy;Caregivers;Caring;Client;Clinic;Clinical;clinical trial recruitment;Collaborations;Collection;Communities;community advisory board;community engagement;Community Health;Community Health Aides;community organizations;Community Services;community setting;Computer software;Continuity of Patient Care;Contracts;cost effective;Data Collection;Development;digital platform;Documentation;efficacy testing;electronic patient reported outcomes;Electronics;Eligibility Determination;Enrollment;Evaluation;Fast Healthcare Interoperability Resources;Feedback;Financial Hardship;food insecurity;Fostering;Funding;Future;Goals;Health;health assessment;Health Care Costs;health goals;health inequalities;health outcome disparity;Health Services Accessibility;Health Status;Health Technology;Hour;housing instability;improved;improved outcome;Individual;Infrastructure;innovation;Learning;Libraries;Logical Observation Identifiers Names and Codes;Malignant Neoplasms;Measures;Medical;mHealth;Minnesota;Modeling;novel;Oncology;Outcome;patient engagement;Patient Recruitments;Patient-Focused Outcomes;Patients;Personal Satisfaction;Phase;Pilot Projects;Population;primary outcome;Process;programs;Public Health;Quality of life;Randomized;randomized, clinical trials;recruit;Reporting;Research;Resources;Sampling;secondary outcome;Services;SF-12;Shapes;Site;Small Business Innovation Research Grant;social;social health determinants;Social Work;Social Workers;Spanish;Surveys;survivorship;Technology;Testing;Time;Travel;treatment as usual;treatment planning;Uninsured Medical Expense;United States National Institutes of Health;Universities;usability

PROJECT_TITLE: ConnectedNest: a digital platform connecting individuals with cancer to social care

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 SCIL-D (10)]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Anxiety Disorders;Autism;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Mental Illness;Neurosciences;Pediatric

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE Untreated anxiety disorders among youth with autism spectrum disorder (ASD) carries tremendous personal and societal costs including serious behavioral problems, failure of occupational or residential placement, and decreased independence. Progress towards the development of interventions that reduce anxiety severity in this population has been limited by difficulties in accurately measuring anxiety severity due to the differences in social communication that are core to ASD. This study will develop objective methods to detect physiological measures of anxiety which will be incorporated into a clinical trial assessing buspirone for the treatment of anxiety in youth with ASD.

PI_NAMEs: THOM, ROBYN P. (contact)

PROGRAM_OFFICER_NAME: SIMS, BELINDA ENITA

PROJECT_TERMS: Accelerometer;acceptability and feasibility;Address;Adolescent;adolescent with autism spectrum disorder;Adverse drug effect;Affect;Aftercare;Agonist;Anxiety;Anxiety Disorders;anxiety reduction;anxiety spectrum disorders;anxiety symptoms;anxiety treatment;Applied Research;autism spectrum disorder;autistic children;Autonomic nervous system;Award;Behavioral;Biological Markers;biomarker validation;Biometry;Blood Pressure;Buspirone;career development;Child;Childhood;Clinical;clinical anxiety;clinical efficacy;clinical heterogeneity;Clinical Trials;Clinical Trials Design;cognitive ability;Cognitive Therapy;comorbidity;Data;data acquisition;Data Analyses;Development;Dropout;effectiveness testing;effectiveness trial;Emotions;Environment;evidence base;Evidence based treatment;experience;Failure;Familiarity;feasibility testing;Functional impairment;Funding;Future;General Hospitals;Goals;Grant;Heart Rate;heart rate variability;Impairment;improved;Individual;innovation;Intellectual functioning disability;Intervention Trial;Knowledge;Laboratories;Leadership;Manuscripts;Massachusetts;Measurement;Measures;medical schools;Mental disorders;Mentors;Mentorship;Meta-Analysis;Methodology;Methods;multi-site trial;novel;Occupational;Parents;Patient Self-Report;Pharmaceutical Preparations;Pharmacotherapy;Phase;Phenotype;Physiological;Placebo Effect;Placebos;Population;preclinical study;Preparation;Principal Investigator;Problem behavior;psychiatric comorbidity;Psychopharmacology;Psychophysiology;Publishing;Quality of life;Randomized;Randomized, Controlled Trials;Reporting;Research;responsible research conduct;Risk;Sample Size;Selective Serotonin Reuptake Inhibitor;Serotonin;Severities;Site;skills;social communication;societal costs;standard care;Stress;symposium;Testing;therapy development;Training;Treatment outcome;treatment response;usability;Work

PROJECT_TITLE: Anxiety in Youth with Autism Spectrum Disorder


NIH_SPENDING_CATS: Clinical Research;Diabetes;Genetics;Human Genome;Wound Healing and Care

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Diabetic wounds are a major cause of amputation and poor quality of life. The proposed work studies genetic factors that influence skin wound closure and utilizes such knowledge to determine risk of diabetic wound chronicity.

PI_NAMEs: SEN, CHANDAN K (contact)

PROGRAM_OFFICER_NAME: LI, YAN

PROJECT_TERMS: Affect;Amputation;Caring;Cells;Chronic;chronic wound;cohort;combinatorial;Complication;Complications of Diabetes Mellitus;Data;Death Rate;Dermatologic;Diabetes Mellitus;diabetic;Diabetic Foot Ulcer;diabetic ulcer;diabetic wound healing;Discipline;DNA Methylation;epithelial wound;Fruit;Gene Expression;Gene Silencing;gene-targeted therapy;Genes;genetic risk factor;Genetic study;genome-wide;Genomics;Genotype;Goals;healing;Healthcare;healthcare burden;Human;Human Genome Project;Hypermethylation;Impairment;Individual;Knowledge;life span;lifetime risk;Longitudinal cohort study;Malignant Neoplasms;Morbidity - disease rate;NOTCH1 gene;novel;Nucleotides;Ontology;Operative Surgical Procedures;Patients;personalized medicine;Persons;Pharmacotherapy;Positioning Attribute;Prevalence;Provider;Quality of life;Research;Risk;Signal Transduction;skin ulcer;skin wound;Techniques;Testing;transcription factor;Transcription Initiation Site;Trauma;United States National Institutes of Health;Variant;Vision;Work;wound;wound closure;wound healing

PROJECT_TITLE: Cell Specific Gene Editing to Close Diabetic Wounds


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Congenital Heart Disease;Congenital Structural Anomalies;Heart Disease;Hematology;Infant Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Rare Diseases;Women's Health Research

ORG_CITY: COLUMBUS

ORG_NAME: RESEARCH INST NATIONWIDE CHILDREN'S HOSP

PHR: NARRATIVE: Clamping and cutting the umbilical cord at birth occurs for each of the 140 million neonates born annually. The significant public health advantages of delayed cord clamping (DCC) over early cord clamping (ECC) for healthy newborns has not been studied in neonates with critical congenital heart disease (CCHD), a population with a high frequency of adverse outcomes and, correspondingly, the potential for substantial benefit from ameliorative interventions. The studies described in the present proposal are relevant to NIH’s mission to understand the processes of human growth and development, by determining, via a multicenter randomized clinical trial, whether, among neonates born with CCHD, DCC provides better outcomes post cardiac surgery or catheterization, as measured by a validated composite measure (global rank scores) and neurodevelopmental outcomes, than are observed with ECC.

PI_NAMEs: BACKES, CARL  (contact);HILL, KEVIN DENNIS;KATHERIA, ANUP C

PROGRAM_OFFICER_NAME: PEMBERTON, VICTORIA

PROJECT_TERMS: Academy;adherence rate;adverse outcome;Age;American;American College of Obstetricians and Gynecologists;Anatomy;Birth;Blood;Body System;Cardiac Catheterization Procedures;Cardiac Surgery procedures;Catheterization;Cesarean section;Child;Child Health;Clinical;clinically significant;Closure by clamp;cohort;Collaborations;Complement;Complex;Conduct Clinical Trials;Congenital Abnormality;congenital heart abnormality;Consent;cost;Critical Care;critical congenital heart disease;Data;Data Coordinating Center;design;Development;Diabetes Mellitus;effectiveness evaluation;Enrollment;Environment;Equipoise;Erythrocyte Transfusion;Ethnic Origin;Event;Evidence Based Medicine;Exclusion;experience;Exposure to;Family;Feasibility Studies;fetal;fetal blood;fetal diagnosis;Frequencies;Functional disorder;General Population;Gestational Age;Goals;Growth and Development function;Guidelines;Health;Health Benefit;Health Personnel;heart defect;Hematology;high risk;High-Risk Pregnancy;Hospitalization;Hospitals;Human;Hyperviscosity;improved;Infant;Infrastructure;Intensive Care;International;Intervention;Iron deficiency anemia;Joints;maternal hypertension;maternal outcome;maternal risk;Measures;Mediating;Mission;mortality;Mothers;Motor;Movement;multidisciplinary;myocardial injury;Neonatal;neonatal morbidity;neonatal resuscitation;neonate;Neurologic;Neurological outcome;Newborn Infant;Operative Surgical Procedures;Outcome;Parents;Patient-Focused Outcomes;Patients;Pediatrics;Perception;Physiological;Placenta;Polycythemia;Population;postnatal;Postpartum Hemorrhage;Pregnancy;primary outcome;Process;Public Health;Questionnaires;Race;Randomized;randomized, clinical trials;Randomized, Controlled Trials;Recommendation;Records;recruit;Reporting;Research Design;Research Personnel;Risk;Safety;secondary outcome;Severities;sex;Site;Stroke;Subgroup;Surveys;Survivors;Testing;Thrombosis;Translating;Umbilical cord structure;Uncertainty;United States National Institutes of Health;Vagina;Vulnerable Populations

PROJECT_TITLE: 1/2 CORD-CHD:  Clamp OR Delay among neonates with Congenital Heart Disease

STUDY_SECTION: CLTR

STUDY_SECTION_NAME: Clinical Trials Review Study Section[CLTR(OA)]