NIH_SPENDING_CATS: Breast Cancer;Cancer;Women's Health Research

ORG_CITY: LOUISVILLE

ORG_NAME: UNIVERSITY OF LOUISVILLE

ORG_STATE: KY

PHR: While clinical responses to CDK4/6 inhibition have been remarkable, metastatic breast cancer remains incurable. The proposed studies will provide the mechanistic base for the combined targeting of PFKFB3 and CDK4/6. The results should facilitate the rational design of combinatorial phase I/II trials of PFKFB3 inhibitors with CDK4/6 agents for the treatment of stage IV ER+ breast adenocarcinoma patients.

PI_NAMEs: IMBERT-FERNANDEZ, YOANNIS  (contact)

PROGRAM_OFFICER_NAME: FORRY, SUZANNE L

PROJECT_TERMS: 6-Phosphofructo-2-kinase;6-Phosphofructokinase;advanced breast cancer;Attenuated;Automobile Driving;base;Binding;Biological Availability;blood glucose regulation;Breast Adenocarcinoma;Breast Cancer Cell;Breast Cancer cell line;Breast Cancer Model;Breast Cancer Patient;Bypass;cancer cell;CDK4 gene;Cell Cycle;Cell Cycle Progression;Cells;Clinical;Clinical Trials;combinatorial;Cyclin D1;cyclin D3;cyclin-dependent kinase 6;Cyclins;design;Development;Disabling;early phase clinical trial;efficacious treatment;Enzymes;ERBB2 gene;Estradiol;Estrogen receptor positive;Estrogen Receptors;FDA approved;Fructose;Genetic;Genetic Transcription;Glucose;glucose metabolism;Glycolysis;Glycolysis Induction;Growth;hormone receptor-positive;hormone therapy;improved;In Vitro;in vivo;inhibitor;Malignant Breast Neoplasm;Malignant Neoplasms;Mediating;Metabolic;Metastatic breast cancer;mouse model;novel;novel strategies;Oncogenic;Oral;overexpression;Pathway interactions;Patients;pharmacologic;Phase;Phase I/II Trial;Phosphorylation;prevent;Progression-Free Survivals;Proliferating;rational design;Relapse;research clinical testing;Resistance;Resistance development;response;Retinoblastoma Protein;Role;targeted treatment;Testing;therapy resistant;Time;treatment response;tumor

PROJECT_TITLE: Targeting 6-Phosphofructo-2-Kinase to increase efficacy of CDK4/6 Inhibitors

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 1 Study Section[MCT1]


ADMINISTERING_IC: CA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Hepatitis;Liver Cancer;Liver Disease;Orphan Drug;Rare Diseases

ORG_CITY: NEW YORK

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: Hepatocellular carcinoma (HCC) is the most common type of liver cancer and the third leading cause of cancer mortality world-wide. In the US, HCC rates have tripled over the last 30 years and a further increase is expected due to the increase in obesity and fatty liver disease. Our proposal will investigate their role of hepatic stellate cells and liver in the development of hepatocellular carcinoma in fatty liver disease, focusing on therapeutically targetable pathways through which they promote and protect from HCC.

PI_NAMEs: SCHWABE, ROBERT F. (contact)

PROGRAM_OFFICER_NAME: WOODHOUSE, ELIZABETH

PROJECT_TERMS: Ablation;Affect;Cancer Etiology;Cell Count;Cell secretion;cell type;Cessation of life;Cholangiocarcinoma;Chronic;chronic liver disease;chronic liver injury;Cirrhosis;Collagen Receptors;Collagen Type I;cytokine;Data;Development;Disease;Disease Progression;Environment;Evolution;Extracellular Matrix;fatty liver disease;Fibroblasts;Fibrosis;Functional disorder;Genetic;genetic approach;Goals;Growth Factor;Hepatic;Hepatic Stellate Cell;Hepatocarcinogenesis;Hepatocyte;HGF gene;Human;Immunity;improved;Incidence;Inflammation;Injury;insight;Ligands;Link;Liver;liver cell proliferation;Liver diseases;Liver Fibrosis;liver injury;Malignant neoplasm of liver;Malignant neoplasm of pancreas;Malignant Neoplasms;Mediating;Mediator;mortality;Mus;Myofibroblast;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;novel;novel therapeutics;Obesity;Outcome;Pathway interactions;Patients;premalignant;Prevention;Primary carcinoma of the liver cells;Production;protective pathway;receptor;Regulation;response;Risk;Risk Factors;Role;Signal Transduction;single-cell RNA sequencing;Source;Stromal Cell-Derived Factor 1;targeted treatment;Therapeutic;Therapeutically Targetable;Time;tumor;tumor microenvironment;Tumor Promotion;viral liver disease;wound

PROJECT_TITLE: Tumor-promoting and tumor-suppressive roles of Hepatic Stellate Cell Subpopulations in NASH-HCC

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Aging;Brain Disorders;Genetics;Neurodegenerative;Neurosciences;Parkinson's Disease;Prevention;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: STONY BROOK

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because revealing if cellular senescence is a general mechanism in dopamine neurons leading to parkinsonism is critical for the understanding of Parkinson’s disease and age- related neurodegeneration. This study aims to identify factors and pathways that cause cellular senescence in dopamine neurons and other cell types of the midbrain, to ultimately unravel how senescence spreads between cell types and how it would be possible to interfere and prevent neurodegeneration. Thus, this proposal is relevant to the part of NIH’s mission that pertains to fostering fundamental creative discoveries and innovative research strategies as a basis for ultimately protecting health.

PI_NAMEs: RIESSLAND, MARKUS  (contact)

PROGRAM_OFFICER_NAME: SULLIVAN, LUIS FLANAGAN

PROJECT_TERMS: Ablation;Adaptive Immune System;Address;age related neurodegeneration;alpha synuclein;AT Rich Sequence;Binding Proteins;Brain;Cell Aging;Cell model;Cell Nucleus;cell type;Cells;Cellular Stress;Clinical;Coculture Techniques;Creativeness;Cues;Development;disease phenotype;DNA Damage;dopaminergic neuron;Eating;Encephalitis;Endothelial Cells;experimental study;Fostering;Functional disorder;Genetic;Goals;Health protection;Human;human old age (65+);Immune;immune activation;Immune response;In Vitro;in vivo;Individual;Inflammaging;Inflammation;Inflammatory;Innate Immune System;innovation;Lead;Mediating;Methods;Microglia;Midbrain structure;Mission;Mitochondria;Mitotic;Molecular;Monitor;motor symptom;Mus;mutant;Mutation;Nerve Degeneration;Neuroglia;neuron loss;Neurons;neuroprotection;novel;Outcome;Outcome Study;Paraquat;Parkinson Disease;Parkinson's Disease Pathway;Parkinsonian Disorders;pars compacta;Pathology;Pathway interactions;Patients;Phenotype;Play;postmitotic;posture instability;Prevalence;prevent;Prevention;programs;Proliferating;Public Health;recruit;release factor;Research;response;Risk Factors;Role;Route;senescence;senescence associated secretory phenotype;senescent cell;senolytics;Signal Transduction;single nucleus RNA-sequencing;Sorting;sporadic Parkinson's Disease;stem cells;Stress;Substantia nigra structure;Symptoms;Time;tool;Toxin;TP53 gene;Tremor;United States National Institutes of Health

PROJECT_TITLE: Molecular Assessment of Cause and Consequence of Cellular Senescence in Diverse Midbrain Cell Types in Parkinson's Disease

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD]


NIH_SPENDING_CATS: Neurosciences

ORG_DEPT: NEUROLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Narrative This study examines mechanisms that are responsible for the assembly of nodes of Ranvier, and other domains of myelinated axons, in the PNS and CNS. We will investigate two complementary mechanisms: the roles of contractile myosin II in promoting node assembly and that of glial induced endocytic clearance in removing nodal components elsewhere, i.e. at extranodal sites. In the future, this research may aid the development of therapies directed at promoting recovery of function in demyelinating neurological disorders.

PI_NAMEs: SALZER, JAMES  (contact)

PROGRAM_OFFICER_NAME: TYLER, WILLIAM A

PROJECT_TERMS: Actins;Action Potentials;Agreement;ANK3 gene;Axon;betaIV spectrin;Binding;Biology;Cell Adhesion Molecules;Central Nervous System;Clathrin;Coculture Techniques;Complex;conditional knockout;Cytoskeleton;Demyelinations;Diameter;Disease;Dynamin I;Endocytosis;Engineering;Extranodal;Fiber;Future;Generations;Genetic;Hippocampus;In Vitro;in vivo;insight;knock-down;Knock-out;Length;loss of function;Macromolecular Complexes;Maintenance;Mediating;Modeling;Morphology;Mus;mutant;myelination;Myosin Heavy Chains;Myosin Light Chains;Myosin Regulatory Light Chains;Myosin Type II;Natural regeneration;Nervous System Disorder;Nervous System Physiology;Neuroglia;Neurons;Nodal;nodal protein;non-muscle myosin;novel;novel therapeutic intervention;Pathogenesis;Peripheral;Phosphorylation;Potassium;Proteins;Proteome;Ranvier's Nodes;Recovery of Function;recruit;repaired;Reporting;Research;Role;scaffold;Signal Transduction;Site;Sodium;Spectrin;Surface;Testing;therapy development;Transgenic Mice;voltage

PROJECT_TITLE: Mechanisms of Node of Ranvier Assembly

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Cancer

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Cancer remains a major cause of morbidity and mortality in the United States, and new approaches to the diagnosis and treatment of cancer are critically needed. This T32 program focuses predominantly on the training of physician-scientists who plan research careers that will improve our understanding of the molecular basis of human cancers. The program is based on the translational and basic science strengths of a Pathology department and Cancer Center, and thus creates a dynamic platform to educate physician-scientists and fundamental researchers in the study of cancer biology.

PI_NAMEs: LANGENAU, DAVID MICHAEL (contact)

PROGRAM_OFFICER_NAME: LIM, SUSAN E

PROJECT_TERMS: Molecular Immunology;Tumor Biology

PROJECT_TITLE: Molecular Immunology and Tumor Biology

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Immunotherapy;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: GAINESVILLE

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Project Narrative High grade glioma is the leading cause of cancer-related death in children. Our preliminary data suggest hematopoietic stem cells and PD-1/PD-L1 inhibiting therapies may promote anti-glioma T cell responses in a thymus-dependent manner. This proposal will characterize the impact of PD-1 blockade on thymocyte development and determine how the thymus promotes anti-tumor responses in the context of hematopoietic stem cell and anti-PD-1 combination therapy.

PI_NAMEs: FRANCIS, CONNOR PATRICK (contact)

PROGRAM_OFFICER_NAME: ODEH, HANA M

PROJECT_TERMS: Ablation;Adoptive Transfer;Affect;anti-PD-1;anti-PD1 therapy;anti-tumor immune response;Antigen Presentation;Antitumor Response;autoreactivity;beta Chain Antigen T Cell Receptor;Binding;Cancer Etiology;Cancer Patient;CD8B1 gene;Cell Physiology;Central Nervous System Neoplasms;childhood cancer mortality;Childhood Glioma;Clinical;clinical decision-making;Clinical Management;Combined Modality Therapy;Data;Data Display;Dendritic Cells;design;Disease;draining lymph node;Ensure;exhaust;experience;Experimental Models;Frequencies;Glioblastoma;Glioma;Goals;Health;Hematopoietic stem cells;Human;Immune checkpoint inhibitor;Immunooncology;Immunotherapy;improved;innovation;Knowledge;leukemia;Ligands;Ligation;Long-Term Survivors;Lymphopoiesis;Malignant Childhood Neoplasm;Malignant Neoplasms;Mediating;Mitotic;Modality;mouse model;Mus;novel;novel therapeutics;Outcome;Output;Pathway interactions;Patients;PDL1 inhibitors;Pediatric Neoplasm;Peripheral;Physiology;Population;prevent;Process;Production;Prognostic Factor;programmed cell death ligand 1;programmed cell death protein 1;Proliferating;Receptor Signaling;Regulation;Rejuvenation;Reporting;Resistance;Signal Pathway;Signal Transduction;Specificity;standard of care;stem cell migration;stem cell therapy;Survival Rate;synergism;T cell infiltration;T cell reconstitution;T cell response;T-Cell Activation;T-Cell Development;T-Cell Receptor;T-cell receptor repertoire;T-Lymphocyte;Testing;Therapeutic;therapy resistant;thymocyte;Thymocyte Development;Thymus Gland;trafficking;Treatment Protocols;treatment response;tumor;Tumor Immunity;tumor microenvironment;tumor-immune system interactions;Tumor-Infiltrating Lymphocytes;Work

PROJECT_TITLE: Thymic PD-1 blockade mediates the anti-tumor immune response in pediatric high-grade glioma


ADMINISTERING_IC: GM

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: WEST LAFAYETTE

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: PROJECT NARRATIVE This project aims to understand mechanisms regulating the Cullin-RING ubiquitin ligases (CRLs), a large family of enzymes that control the activity and degradation of numerous critical regulatory proteins in human cells. Dysfunction and misregulation of CRLs can lead to various diseases such as cancers and muscle dystrophies, and a member of CRLs, Crbn, is responsible for the anticancer activity of the drug thalidomide. Our research findings will provide a foundation for understanding the pathogenesis of CRL-related diseases and inform novel strategies for the prevention and treatment of these diseases.

PI_NAMEs: LIU, XING  (contact)

PROGRAM_OFFICER_NAME: BARSKI, OLEG

PROJECT_TERMS: anticancer activity;Arabidopsis;Biochemistry;Biological;Biological Assay;Biophysics;cell type;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Cullin Proteins;Defect;Development;Diagnosis;Disease;Ensure;Environment;Enzymes;Eukaryotic Cell;Family;Foundations;Functional disorder;genetic regulatory protein;genome editing;Guanine Nucleotide Exchange Factors;Homologous Gene;Human;human disease;IL27RA gene;Immunoprecipitation;Impairment;In Vitro;insight;Kinetics;Ligase;Malignant Neoplasms;Mass Spectrum Analysis;mathematical model;member;Metabolic Diseases;Molecular Genetics;muscle degeneration;Muscular Dystrophies;Nerve Degeneration;novel;novel strategies;Organism;Pathogenesis;Performance;Pharmaceutical Preparations;Plant Model;Play;Prevention;Prevention strategy;Process;protein complex;Proteins;Proteome;Proteomics;receptor;recruit;Recycling;Reporting;Research;Role;scaffold;System;Techniques;Thalidomide;Time;Ubiquitin;ubiquitin ligase;ubiquitin-protein ligase;Ubiquitination;Update;Work

PROJECT_TITLE: Regulatory Mechanism of Cullin-RING Ubiquitin Ligases

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-T(55)R]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Asthma;Clinical Research;Clinical Trials and Supportive Activities;Lung;Pediatric

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PROJECT NARRATIVE AND RELEVANCE The proposed R34 and future R61-R33 research are relevant to public health because they focus on repurposing a safe, inexpensive, anti-inflammatory medicine (oral montelukast) to decrease hospitalizations of children with acute asthma exacerbations. This research may lead to more effective and personalized treatment for these children by selectively augmenting or replacing systemic corticosteroid, the only anti- inflammatory medicine currently available and one with concerning side effects. Thus, the proposed research is relevant to the NHLBI mission to promote treatment of lung disease and enhance the health of individuals to live longer and more fulfilling lives.

PI_NAMEs: ARNOLD, DONALD HAYES (contact)

PROGRAM_OFFICER_NAME: FREEMER, MICHELLE M

PROJECT_TERMS: Accident and Emergency department;Acute;Address;Adrenal Cortex Hormones;Adult;Affect;Aftercare;Agonist;airborne allergen;airway inflammation;Albuterol;Allergic rhinitis;Anti-Inflammatory Agents;Asthma;asthma exacerbation;Black race;Bronchoconstriction;Bronchodilator Agents;Child;Chronic;Clinical;Clinical Trials;computerized;Control Groups;cysteinyl-leukotriene;Data;Decision Making;design;Dose;Drug Kinetics;effective therapy;eosinophil;FDA approved;Funding;Future;Goals;Guidelines;Health;Hospitalization;hospitalization rates;Hospitalized Child;Hour;improved;improved outcome;Individual;Inflammation;Inflammation Mediators;Inflammatory;Ingestion;Inhalation;inhibitor;innovation;Intravenous;Knowledge;Leukotriene Antagonists;Leukotriene E4;Leukotrienes;Low income;Lung Diseases;Masks;mast cell;Measures;Mediating;Medicine;Mission;Modeling;montelukast;Morbidity - disease rate;National Heart, Lung, and Blood Institute;novel;Oral;Outcome;Participant;Pathway interactions;personalized medicine;Pharmaceutical Preparations;Phase;Placebos;Plasma;Public Health;pulmonary function;Randomized;Recommendation;Relapse;Research;response;Safety;Severities;side effect;standard care;Stress;Testing;Time;Update;urinary;Viral Respiratory Tract Infection;Weight

PROJECT_TITLE: Dose escalation clinical trial of high-dose oral montelukast to inform future RCT in children with acute asthma exacerbations

STUDY_SECTION: SSPT

STUDY_SECTION_NAME: NHLBI Single-Site and Pilot Clinical Trials Study Section[SSPT(JA)]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;HIV/AIDS;Immunization;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: BETHESDA

ORG_NAME: HENRY M. JACKSON FDN FOR THE ADV MIL/MED

ORG_STATE: MD

PHR: Project Narrative We previously demonstrated that HIV neutralization breadth can be shaped during early HIV infection and develops more frequently following infection with multiple founder variants (MFV). Preliminary data indicate that a multivalent HIV Env vaccine composed of a cocktail of minimally distant, stabilized Env trimer proteins formulated with ALFQ elicited broader neutralizing antibody responses than a more traditional single Env trimer immunization. Our goal is to develop a multivalent clinical HIV vaccine candidate that consists of multiple minimally distant HIV Env trimers corresponding to multiple founder variants and elicits robust protective neutralizing responses against HIV.

PI_NAMEs: VASAN, SANDHYA  (contact)

PROGRAM_OFFICER_NAME: SINGH, ANJALI

PROJECT_TERMS: acute infection;Address;Adjuvant;Antibodies;Antibody Response;Antibody titer measurement;Antigens;B-Cell Activation;B-Cell Development;B-Lymphocytes;base;Binding;Cell Maturation;Chronic;Clinical;Clinical Trials;Cobalt;cohort;Cohort Studies;Complementarity Determining Regions;Complex;Data;design;Development;Distant;Dose;efficacy trial;Engineering;env Gene Products;Epitopes;Evaluation;Frequencies;Germ Lines;glycosylation;Goals;Grant;Growth;HIV;HIV envelope protein;HIV Infections;HIV vaccine;HIV Vaccine Trials Network;HIV-1;HIV-1 vaccine;Human;Immune;Immune response;Immunization;immunogenicity;Immunoglobulin M;Immunologics;improved;in silico;In Vitro;in vivo;Individual;Infection;Knowledge;Lead;Length;liposomal formulation;Liposomes;Macaca mulatta;manufacture;manufacturing test;Messenger RNA;Military Personnel;Modeling;Modification;Molecular Conformation;mosaic;Mutation;neutralizing antibody;neutralizing monoclonal antibodies;nonhuman primate;novel strategies;novel vaccines;Oryctolagus cuniculus;Participant;Persons;Pharmacologic Substance;Phase;Phospholipids;Polysaccharides;Porphyrins;preclinical study;prevent;Prevention strategy;Preventive;Process;programs;protective efficacy;Proteins;QS21;Rectum;Regimen;repaired;Reporting;Research;research clinical testing;response;RNA vaccine;Sampling;self assembly;Shapes;Signal Transduction;simian human immunodeficiency virus;Specific qualifier value;Structure of germinal center of lymph node;T cell response;Testing;Vaccination;Vaccine Adjuvant;vaccine candidate;vaccine delivery;Vaccine Design;vaccine development;vaccine formulation;vaccine platform;vaccine strategy;Vaccines;Variant;Virus

PROJECT_TITLE: Designing HIV-1 envelope immunogens to maximize neutralization breadth through use of multiple founder envelope antigens


ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative Broadly reactive neutralizing antibodies can be used for HIV-1 prevention, treatment and eradication of persistent viral infection. We aim to develop novel strategies to enhance antibody-mediated cell-killing functions. Our study will improve antibody therapeutic efficacy in order to achieve a functional cure of HIV.

PI_NAMEs: SHAN, LIANG  (contact)

PROGRAM_OFFICER_NAME: SANDERS, BRIGITTE E

PROJECT_TERMS: Anatomy;Animal Model;Antibodies;antibody engineering;antibody test;Antibody Therapy;antibody-dependent cell cytotoxicity;antibody-dependent cellular phagocytosis;Antibody-Dependent Enhancement;antiretroviral therapy;Binding;Biopsy;Bispecific Antibodies;Blocking Antibodies;Blood specimen;CD4 Positive T Lymphocytes;CD47 gene;cell killing;Cell model;Cell Physiology;Cells;Clinical;cytokine;Dichloromethylene Diphosphonate;DNA;Effector Cell;experimental study;Fc Immunoglobulins;Fc Receptor;FCGR3B gene;functional improvement;Goals;Grant;Granzyme;HIV;HIV Infections;HIV-1;Human;human tissue;humanized mouse;IgG Receptors;IL18 gene;Immunotherapeutic agent;improved;In Vitro;Infection;Interferons;Interleukin-12;Interleukin-15;interleukin-21;Interruption;latent HIV reservoir;latent infection;lymph nodes;Lymphoid Tissue;Macrophage;Measures;Mediating;Modeling;Monitor;monocyte;mouse model;Mus;mutant;Mutation;Natural Killer Cells;neutralizing antibody;novel strategies;Patients;perforin;peripheral blood;Phagocytes;Phagocytosis;Plasma;Play;Prevention;Production;Proteins;PTPNS1 gene;receptor;Receptor Signaling;Research;Residual state;Rest;RNA;Role;SHPS-1 protein;Signal Transduction;Site;Testing;Therapeutic antibodies;Therapeutic Effect;Tissues;Tonsil;Treatment Efficacy;Viral;Viral Antibodies;viral rebound;Viral reservoir;viral RNA;Virus;Virus Diseases

PROJECT_TITLE: Novel Strategies to Enhance Effector Cell Functions for Antibody-Mediated Clearance of HIV-1 Infection

STUDY_SECTION: HIVD

STUDY_SECTION_NAME: HIV Immunopathogenesis and Vaccine Development Study Section[HIVD]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Nanotechnology;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_CITY: MADISON

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE  Influenza B viruses (IBVs) cause respiratory disease in humans every year. Current vaccines for IBVs are sub-optimal and must be updated frequently. In response to RFA-AI-20-003, which calls for the “development and/or characterization of IBV vaccine components that complement existing lead IAV vaccine candidates”, we propose to test a novel strategy for the development of broadly protective IBV vaccines.

PI_NAMEs: KAWAOKA, YOSHIHIRO  (contact)

PROGRAM_OFFICER_NAME: GORDON, JENNIFER L

PROJECT_TERMS: Address;Adjuvant;Affect;Alhydrogel;Animals;Antibodies;Antibody titer measurement;Antigens;Attenuated Vaccines;Bacteriophages;Biological Assay;CD8-Positive T-Lymphocytes;Cells;Complement;Control Animal;cross reactivity;cytokine;Data;design;Development;Epidemic;Epitopes;Euthanasia;experimental study;Ferrets;future epidemic;Hemagglutinin;Human;Immune response;Immunity;Immunization;Immunize;immunogenicity;Immunology;improved;Infection;Influenza A virus;Influenza A Virus, H1N1 Subtype;Influenza A Virus, H3N2 Subtype;Influenza B Virus;influenza virus strain;influenza virus vaccine;influenzavirus;Lead;Libraries;lymph nodes;Maps;Morbidity - disease rate;mortality;Mutagenesis;mutant;Mutation;nanoparticle;novel;novel strategies;Organ;Peptides;Phage Display;Pharmaceutical Preparations;Phase;Population;Property;protective efficacy;Proteins;Recombinants;Research;respiratory;Respiratory Disease;response;Saint Jude Children's Research Hospital;self assembly;Serum;Spleen;stem;Testing;universal vaccine;Update;Vaccinated;Vaccination;vaccine access;vaccine candidate;vaccine efficacy;Vaccines;Variant;Viral Antigens;Viral Proteins;Virus

PROJECT_TITLE: Development of broadly-protective vaccines for influenza B viruses

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IMM-T(50)]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Eye Disease and Disorders of Vision;Genetics;Infectious Diseases;Neurosciences;Orphan Drug;Rare Diseases;Vector-Borne Diseases

PHR: Project Narrative River blindness is a major neglected chronic tropical disease caused by a parasitic filarial nematode, Onchocerca volvulus, that affects an estimated 25 million people worldwide. Approximately 270,000 are blind and 1.2 million people are visually impaired by river blindness. The World Health Organization's goal is to eliminate this disease by 2030, however, this is unlikely achievable using the existing drug ivermectin that only targets transmission of infection. The long-term goal of this project is to overcome this barrier by rationally identify, optimize and develop new drug candidates to complement the present control interventions, and consequently facilitate the likelihood of eliminating this filarial disease that affects populations in mostly poor, developing countries.

PI_NAMEs: JANETKA, JAMES W;LUSTIGMAN, SARA ;MITREVA, MAKEDONKA  (contact);SAKANARI, JUDY

PROGRAM_OFFICER_NAME: MCKIE, GEORGE ANN

PROJECT_TERMS: Acceleration;Address;Adult;Affect;Africa;analog;Animal Model;Area;Aspartic Endopeptidases;Autopsy;Biochemical;Biological Assay;Biological Availability;blind;Brugia pahangi;Cell Line;Chemicals;Chronic;Chronic Disease;Clinical;Complement;design;Developing Countries;Development;Dimensions;Disease;Docking;drug candidate;drug discovery;Drug Targeting;drug use screening;efficacy validation;Encephalopathies;Evaluation;Evaluation Studies;Female;Fertility;Filariasis;G-Protein-Coupled Receptors;Genetic Transcription;Goals;Homology Modeling;Human;in silico;In Vitro;in vivo;in vivo evaluation;Individual;Infection;inhibitor;innovation;interdisciplinary approach;International;Interruption;Intervention;Intestinal Volvulus;Ivermectin;Jird;knock-down;Knowledge;Lead;lead candidate;lead optimization;Libraries;Ligands;Loa;Loa loa;Loiasis;meetings;metabolomics;meter;Modeling;Molecular;Molecular Target;Motility;multidisciplinary;neglect;Nematoda;novel;novel therapeutics;Ocular Onchocerciasis;Onchocerca;Onchocerca volvulus;Onchocerciasis;Oral;Organizational Objectives;Orthologous Gene;Outcome;Parasites;Persons;Pharmaceutical Preparations;pharmacophore;Phenotype;Pimozide;Population;pre-clinical;preclinical evaluation;preclinical study;process optimization;programs;Property;Protease Inhibitor;rational design;Recombinant Proteins;Research;Resources;response;Risk;Ritonavir;RNA Interference;Rodent;Rodent Model;scaffold;Schedule;screening;Selection Criteria;Series;Serious Adverse Event;Structure;Systems Biology;targeted treatment;Testing;Therapeutic;Toxic effect;transcriptome sequencing;transcriptomics;transmission process;Tropical Disease;Validation;Visually Impaired Persons;World Health Organization

PROJECT_TITLE: Integrative approach for accelerating filarial worm drug discovery to treat river blindness

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AIDC-Y(02)]


NIH_SPENDING_CATS: Genetics

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: PROJECT NARRATIVE A failure to properly segregate replicated chromosomes has been directly linked to human cancers and severe developmental disorders. Defining the molecular mechanisms that underlie this essential process will inform new ways to combat these diseases. Bacterial cell wall biogenesis is the target of some of the most highly effective and widely used antibiotics; a deeper understanding of how cell wall synthesis pathways are coordinated and maintained has the potential to uncover novel targets for therapeutic intervention.

PI_NAMEs: RUDNER, DAVID Z (contact)

PROGRAM_OFFICER_NAME: MACARTHUR, LINDA

PROJECT_TERMS: 3-Dimensional;Antibiotics;ATP phosphohydrolase;Bacillus subtilis;Bacteria;Biogenesis;Cell Wall;Cells;Cellular biology;Chromatin Loop;chromosome replication;Chromosomes;combat;Complex;condensin;crosslink;Cytolysis;Cytoprotection;Defect;developmental disease;Differentiation and Growth;Disease;DNA;Ensure;Enzymes;Eukaryota;Failure;Goals;Growth;Human;Hydrolase;inorganic phosphate;insight;Knowledge;Link;Lipids;Maintenance;Malignant Neoplasms;Mediating;Molecular;Monitor;Morphology;new therapeutic target;Organism;Osmosis;Pathway interactions;Peptides;Peptidoglycan;Play;Polysaccharides;Process;repaired;Replication Origin;Research;Resolution;Role;segregation;Shapes;Signal Transduction;Signal Transduction Pathway;Sister;Sister Chromatid;Site;System;therapeutic development;Therapeutic Intervention;virtual;Walking

PROJECT_TITLE: Growth and differentiation in Bacillus subtilis

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


NIH_SPENDING_CATS: Cancer;Precision Medicine;Prostate Cancer;Urologic Diseases

ORG_CITY: ATLANTA

ORG_DEPT: CHEMISTRY

ORG_NAME: GEORGIA INSTITUTE OF TECHNOLOGY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Prostate cancer (PCa) is the most diagnosed cancer among men in developed countries including the United States. Despite advances in PCa screening, more than a quarter of a million men die globally from the disease every year due to lack of effective treatment and emergence of castration resistant prostate cancer (CRPC). The overall goal of this proposal is to develop small molecules to treat CRPC, by directly targeting both androgen receptor (AR) and AR-splice variants (AR-SV).

PI_NAMEs: DAMODARAN, CHENDIL ;OYELERE, ADEGBOYEGA  (contact)

PROGRAM_OFFICER_NAME: AGYIN, JOSEPH KOFI

PROJECT_TERMS: abiraterone;Androgen Antagonists;androgen independent prostate cancer;Androgen Receptor;Androgens;Antineoplastic Agents;Apoptosis;Biological Availability;Cancer Cell Growth;cancer diagnosis;cancer drug resistance;Cancer Etiology;cancer therapy;Cell Proliferation;Cells;clinical candidate;Clinical Research;clinically relevant;Coupled;cytotoxicity;Dependence;Developed Countries;Development;Disease;Down-Regulation;Drug Kinetics;Drug or chemical Tissue Distribution;Drug resistance;effective therapy;enzalutamide;Enzymes;Epigenetic Process;Event;Foundations;Functional disorder;Future;Generations;Goals;Growth;HDAC1 gene;Histone Deacetylase;Histone Deacetylase Inhibitor;Histones;implantation;improved;In Vitro;in vivo Model;inhibitor;insight;Investigational Drugs;Lead;Mainstreaming;Malignant neoplasm of prostate;Mediating;member;men;Modeling;nanomolar;Neoplasm Metastasis;neoplastic cell;new therapeutic target;novel;Oral Administration;Outcome;patient derived xenograft model;Patients;Phase I Clinical Trials;Pre-Clinical Model;preclinical efficacy;Property;prostate cancer cell;prostate cancer cell line;prostate cancer model;prostate cancer progression;Prostate Cancer therapy;rational design;receptor expression;Receptor Inhibition;Receptor Signaling;Regulation;Research;Resistance;Resistance development;resistance mechanism;RNA Splicing;Role;Screening for Prostate Cancer;small molecule;Solid Neoplasm;standard of care;Stimulus;Structure-Activity Relationship;targeted agent;targeted treatment;Therapeutic;therapy resistant;Toxic effect;Toxicology;Treatment Efficacy;tumor;tumor growth;United States;Variant;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Development of Novel Targeted Therapeutic Agents for Castration Resistant Prostate Cancer

STUDY_SECTION: DT

STUDY_SECTION_NAME: Developmental Therapeutics Study Section[DT]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease

ORG_CITY: SAN FRANCISCO

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE The UCSF Oral and Craniofacial Sciences training program educates diverse students to apply scientific approaches to solve the most challenging problems in dental, oral and craniofacial health. The goal of this training grant is to provide the financial resources for education and training of DDS/PhD, PhD and postdoctoral fellows to become influential leaders in academic and industrial biomedical research, and other fields related to dental, oral and craniofacial science.

PI_NAMEs: DEN BESTEN, PAMELA K (contact)

PROGRAM_OFFICER_NAME: MCGUIRL, MICHELE

PROJECT_TERMS: craniofacial;health science research;Oral;Research Training

PROJECT_TITLE: Oral and Craniofacial Sciences Health Research Training


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Prostate Cancer;Urologic Diseases

ORG_CITY: Aurora

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Prostate cancer is a complex disease characterized by genetic alterations in the cancer cell. This project will characterize androgen signaling in an aggressive subtype of prostate cancer. This project could identify new pathways that could be targeted to treat prostate cancer.

PI_NAMEs: CRAMER, SCOTT D (contact)

PROGRAM_OFFICER_NAME: KAI, MIHOKO

PROJECT_TERMS: advanced prostate cancer;androgen independent prostate cancer;Androgens;Animal Model;Apoptotic;Binding;Biochemical;cancer cell;Cancer Patient;Castration;Cell model;Cells;CHD1 gene;ChIP-seq;Clinical;Clinical Data;cohort;Collaborations;Complex;CWR22Rv1;Data;Development;Disease;Disease-Free Survival;DNA Sequence Rearrangement;E-Cadherin;enzalutamide;Eph Family Receptors;Ephrins;functional genomics;Future;Gene Expression;Genes;genomic data;Genomics;Global Change;Growth;Human Cell Line;In Vitro;in vivo;innovation;Invaded;KLK3 gene;knock-down;LAPC4;Length;LNCaP;Malignant neoplasm of prostate;MAP3K7 gene;Mediating;men;Messenger RNA;Metastatic malignant neoplasm to brain;Modeling;Motility;mRNA Expression;Mus;Mutation;Neurons;Neurosecretory Systems;new therapeutic target;novel;Nuclear Atypia;Pathway interactions;Patient-Focused Outcomes;Patients;Phenotype;Primary Neoplasm;Prognosis;Prostate;prostate cancer model;prostate carcinogenesis;protein expression;Protein Isoforms;Proteins;Receptor Protein-Tyrosine Kinases;Recurrence;Regulation;Relapse;Resistance;Risk;RNA Splicing;Role;Sampling;Sequence Deletion;Signal Transduction;Spliceosomes;stem cells;success;Testing;The Cancer Genome Atlas;Therapeutic;transcriptome sequencing;Transforming Growth Factor beta;Translating;tumor;Up-Regulation;Variant;Work

PROJECT_TITLE: Androgen Signaling in CaP with loss of MAP3K7 and CHD1

STUDY_SECTION: TCB

STUDY_SECTION_NAME: Tumor Cell Biology Study Section[TCB]


NIH_SPENDING_CATS: Aging;Atherosclerosis;Cardiovascular;Clinical Research;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_CITY: MILWAUKEE

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

PHR: Coronary artery disease (CAD) is the leading cause of death for both men and women in the US. It has become increasingly evident that coronary microvascular dysfunction plays a pivotal role in myocardial ischemia and predicts outcomes of patients with CAD. Our application addresses a change of vasodilation mechanism as an underlying cause of coronary microvascular dysfunction.

PI_NAMEs: ZHANG, DAVID X. (contact)

PROGRAM_OFFICER_NAME: OH, YOUNGSUK

PROJECT_TERMS: acute stress;Address;Adipose tissue;Aging;analog;Animal Disease Models;Animal Model;Arachidonic Acids;Arteries;arteriole;Atherosclerosis;Binding;Binding Sites;Blood Vessels;Cause of Death;Cell Separation;Cells;Compensation;Coronary;Coronary Arteriosclerosis;Cyclic AMP-Dependent Protein Kinases;design;Disease;eicosanoid metabolism;Electrophysiology (science);Endothelial Cells;endothelial dysfunction;Endothelium;Enzymes;Equilibrium;Functional disorder;Funding;gain of function;Gene Expression;Genetic Polymorphism;Goals;Health;Homeostasis;Homologous Gene;Human;human disease;human model;human tissue;Hydrogen Peroxide;Image;Impairment;improved;in vivo;Inflammation;inhibitor;innovation;insight;Ion Channel;Knock-out;Ligands;lipophilicity;Mass Spectrum Analysis;Mediating;Mediator;men;Metabolism;Microcirculation;Microvascular Dysfunction;mimetics;Mitochondria;Modeling;Molecular;molecular modeling;Mutagenesis;Myocardial Ischemia;NADPH Oxidase;Nitric Oxide;novel;novel strategies;Outcome;outcome prediction;Oxidation-Reduction;patch clamp;Pathogenesis;Pathologic;Pathology;Pathway interactions;Patient-Focused Outcomes;Patients;pharmacologic;Phospholipase A2;Phosphorylation;Play;Process;Production;Protein Isoforms;Proteins;Reactive Oxygen Species;receptor;Regulation;release factor;Role;Signal Transduction;Small Interfering RNA;structural biology;Structural Models;Structure;synergism;targeted treatment;Testing;transcriptome sequencing;Transfection;TRP channel;Vanilloid;Variant;Vascular Diseases;Vasodilation;Vasodilator Agents;vasomotion;Woman

PROJECT_TITLE: TRP channels in the regulation of vascular tone

STUDY_SECTION: VCMB

STUDY_SECTION_NAME: Vascular Cell and Molecular Biology Study Section[VCMB]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Project Narrative Loss of function progranulin (GRN) mutations, which typically cause progranulin haploinsufficiency, are a major cause of frontotemporal dementia (FTD). Progranulin-boosting therapies are a promising treatment strategy for FTD-GRN, but the most effective strategy for boosting progranulin remains unclear due to progranulin’s complex cellular trafficking and diverse effects in a variety of cell types. We propose to investigate the cellular and molecular mechanisms by which progranulin insufficiency causes FTD, with the goal of identifying the cellular site of action for progranulin-boosting therapy.

PI_NAMEs: ARRANT, ANDREW EMMETT (contact)

PROGRAM_OFFICER_NAME: SHEWMAKER, FRANK PAUL

PROJECT_TERMS: Address;Adverse effects;Age;Age Months;Alzheimer's Disease;Antiinflammatory Effect;axon growth;Behavior;Behavioral;Cathepsins;Cathepsins B;cell type;Complex;Cytoplasm;Dendrites;design;efficacy evaluation;extracellular;Fluorescent Dyes;FOS gene;Frontotemporal Dementia;Functional disorder;Genetic;Genetic Polymorphism;Goals;Growth;immunoreaction;Impairment;improved;insight;Knowledge;Lentivirus Vector;loss of function;Lysosomes;Measures;Medial;Mediating;Microinjections;minimal risk;Modeling;Molecular;mouse model;Mus;Mutation;neural circuit;Neurites;neuron loss;Neurons;novel;Nuclear;Pathogenesis;Pathogenicity;Pathology;Patients;PGRN gene;pleiotropism;Prefrontal Cortex;protein TDP-43;Risk;Risk Reduction;Safety;Signal Transduction;Site;Social Behavior;social deficits;Social Dominance;Structure;targeted treatment;Testing;Thalamic structure;Therapeutic;trafficking;Transgenic Mice;treatment strategy;tumor growth;Tumor Promotion;Ubiquitin;vector;Viral Vector;Work

PROJECT_TITLE: Mechanisms of Thalamocortical Dysfunction and Social Deficits in FTD due to GRN Mutations


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Childhood Obesity;Eating Disorders;Estrogen;Mental Health;Mental Illness;Neurosciences;Nutrition;Obesity;Pediatric;Women's Health Research

ORG_DEPT: PSYCHIATRY

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: The prepubertal hormonal surge that primes the rapid social and emotional development of adolescence may accelerate risk for disordered eating and the development of binge eating, particularly among girls. This project will test a model of sex differences in risk for binge eating that positions differential gonadal hormone influences on the development of functional brain networks in girls relative to boys as a key determinant of accelerated risk for disordered eating during this vulnerable period. Validation of this model would constitute important progress in delineating the neuroendocrine basis of sex differences in eating disorder risk and could have wide applicability to other behavioral and psychosocial problems characterized by altered responses to natural environmental cues (food, substances of abuse, etc.).

PI_NAMEs: HILDEBRANDT, THOMAS B;SCHULZ, KURT P. (contact)

PROGRAM_OFFICER_NAME: THOMAS, LAURA ANDERSON

PROJECT_TERMS: 10 year old;12 year old;13 year old;Acceleration;Accounting;Adolescence;Adolescent;Age;Anterior;Arousal;Back;Behavior;Behavioral;Binge Eating;boys;Brain;Central Nervous System;Clinical;Cognitive;cognitive development;cohort;Computer Models;Corpus striatum structure;cost;critical developmental period;Cues;Data;Development;Diagnosis;disorder risk;early adolescence;Eating Behavior;Eating Disorders;Emotional;emotional experience;Endocrine;Ensure;Environment;feeding;Female;financial incentive;follow-up;Food;Functional Magnetic Resonance Imaging;functional status;Genetic Risk;girls;Gonadal Hormones;Graph;heuristics;Hormonal;Hormones;Hyperphagia;Inferior;Insula of Reil;Link;Locomotion;longitudinal dataset;Mediating;Mediation;Modality;model building;Modeling;motivated behavior;Motor Activity;Neurobiology;Neurosecretory Systems;Ovarian hormone;Positioning Attribute;preadolescence;prepuberty;Property;Psychological Techniques;psychosocial;Puberty;Research;response;reward processing;Rewards;Risk;Role;Seminal;sensory input;sex;Sex Differences;sexual dimorphism;Signal Transduction;social;Social Environment;Substance of Abuse;Testing;theories;Twin Studies;Validation;Work

PROJECT_TITLE: General Brain Arousal and Risk for Eating Disorder

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


NIH_SPENDING_CATS: Aging;American Indian or Alaska Native;Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Colorectal Cancer;Comparative Effectiveness Research;Digestive Diseases;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Telehealth

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative mPATH-Cloud is an innovative digital health platform that delivers evidence-based and culturally responsive communication and navigation to help patients receive colorectal cancer screening, a widely recommended test that decreases mortality. However, while this type of technology has proven effective for routine, face-to- face primary care appointments, there is increasing interest and demand for reaching more diverse and marginalized patients beyond the confines of the traditional clinical visit. This project will determine the effectiveness and optimal way to implement mPATH-Cloud as fully remote and culturally responsive strategy for increasing CRC screening among low-income, rural and racially diverse patients.

PI_NAMEs: FRERICHS, LEAH M. (contact)

PROGRAM_OFFICER_NAME: DORIA-ROSE, PAUL P

PROJECT_TERMS: Address;Affect;Age;American;American Indians;Appointment;Attention;Black race;Black, Indigenous, People of Color;Cancer Etiology;Caring;Cessation of life;Clinic;Clinical;Colonoscopy;Colorectal Cancer;colorectal cancer screening;Communication;cost;COVID-19 pandemic;Decision Aid;demographics;digital health;Disparity;Dissemination and Implementation;Education;Effectiveness;effectiveness evaluation;effectiveness/implementation design;evidence base;Face;Feces;Federally Qualified Health Center;Friends;Future;future implementation;Geographic Locations;Goals;Guidelines;Health Resources;Health system;Healthcare Systems;Hispanic;implementation evaluation;implementation outcomes;implementation process;improved;Individual;Inequity;innovation;interest;Intervention;Interview;Knowledge;Lead;Linguistics;Low income;Mail Order;Malignant Neoplasms;marginalization;Marketing;Measures;member;Methods;Modeling;Morbidity - disease rate;mortality;multi-component intervention;Neighborhood Health Center;new technology;North Carolina;novel;Outcome;Outcome and Process Assessment;outreach;patient oriented;patient population;patient subsets;Patients;Persons;Population Heterogeneity;Preventive service;Primary Care;Process;Process Measure;profiles in patients;Provider;Race;racial diversity;Randomized;randomized trial;Recommendation;remote delivery;remote health care;Research;Resources;response;Rural;rural area;Rural Community;screening;screening program;Services;socioeconomics;Structural Racism;Subgroup;tailored messaging;Technology;Testing;tool;Translating;treatment as usual;United States;Visit;Work

PROJECT_TITLE: Evaluating a remotely delivered, digital health CRC screening intervention among racially diverse patients of a community health center

STUDY_SECTION: CMGC

STUDY_SECTION_NAME: Clinical Management in General Care Settings Study Section[CMGC]


NIH_SPENDING_CATS: Bioengineering

ORG_DEPT: ANATOMY/CELL BIOLOGY

PHR: Project Narrative Inside the living cell, the cytoplasm is a crowded place occupied by a diverse collection of dynamic molecular constituents. How this environment supports life processes is still not well understood. These studies will show how this crowded environment influences cellular processes such as cytoskeletal and chromosomal dynamics, control of nuclear size control and cell growth.

PI_NAMEs: CHANG, FRED  (contact)

PROGRAM_OFFICER_NAME: MILLER, RITA K

PROJECT_TERMS: Aging;Biological Process;biophysical properties;Cell Cycle;Cell division;cell growth;Cell Nucleus;Cell Physiology;Cell Wall;Cells;Cellular Assay;Cellular biology;Chromosomes;Collection;Crowding;Cytoplasm;Cytoskeleton;density;Development;Disease;DNA Repair;Environment;Fission Yeast;Foundations;Goals;Image;innovation;Investigation;Life;macromolecule;Malignant Neoplasms;Mechanics;Microtubules;Mitosis;Mitotic spindle;Molecular;molecular dynamics;Motility;Nuclear;Nucleic Acids;Nucleoplasm;Organelles;Osmotic Pressure;Pathogenesis;Phase;Physiological;Process;Proteins;Rheology;small molecule;Water;Work

PROJECT_TITLE: Mechanics of cell growth and division

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-D(55)R]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: ALBUQUERQUE

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR

ORG_STATE: NM

PHR: NARRATIVE The Center for Brain Recovery and Repair will strengthen its interdisciplinary team of basic science and clinical investigators, with the goal of discovery of new and effective treatments to accelerate recovery of function for stroke and traumatic brain injury survivors. The Center will continue to develop innovative new research programs, supported by intensive mentoring and state-of-the-art resources. These efforts provide a hub for brain injury research in New Mexico, and aim to ultimately benefit the large number of New Mexicans and their families living with the consequences of debilitating brain injuries.

PI_NAMEs: SHUTTLEWORTH, CLAUDE W (contact)

PROGRAM_OFFICER_NAME: KOVBASNJUK, OLGA NIKOLAEVNA

PROJECT_TERMS: Acceleration;Acute Brain Injuries;Address;Adoption;Animal Experimentation;Basic Science;Behavior;behavioral health;Brain;brain health;Brain Injuries;brain research;career;Caring;Cell Nucleus;Centers of Research Excellence;Clinical;clinical application;Clinical Investigator;Cognitive;cognitive control;cognitive testing;cohort;Collaborations;Communities;community living;Core Facility;cost;data streams;Dedications;Development;effective intervention;effective therapy;Electrophysiology (science);Ensure;equipment acquisition;Evolution;Exposure to;Extramural Activities;Faculty;faculty mentor;Family;Fertilization;Funding;Goals;Grant;Home;Hospitals;Image;improved;Individual;injured;innovation;Inpatients;Institution;interdisciplinary collaboration;Interdisciplinary Study;Intervention;Laboratories;Leadership;Life;Lifelong disability;Long term disability;Mentors;Methods;Mexican;mortality;Motor;multimodal data;Neuroanatomy;Neurons;neurophysiology;New Mexico;novel;Outcome;Outpatients;Patients;personalized approach;Phase;Physiology;Positioning Attribute;pre-clinical;prevent;programs;Quality of life;Recovery;Recovery of Function;repaired;Research;Research Personnel;Resource Sharing;Resources;Rodent;Rodent Model;senior faculty;Services;Severities;societal costs;Stroke;Structure;Students;success;Survivors;symposium;tenure track;Time;Training;Trauma;Traumatic Brain Injury;Traumatic injury;Universities;Work

PROJECT_TITLE: University of New Mexico (UNM) Center for Brain Recovery and Repair


NIH_SPENDING_CATS: Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Neurosciences

PROJECT_TERMS: Acute Brain Injuries;Address;Advisory Committees;base;Brain;Brain Diseases;Brain Injuries;Capital;career development;Centers of Research Excellence;cohort;Collaborations;Communication;Communities;Core Facility;Educational workshop;Effectiveness;Ensure;Environment;Equipment;equipment acquisition;Evaluation;Evolution;Facility Accesses;Faculty;faculty mentor;faculty support;Feedback;Foundations;Funding;Goals;Grant;Home;improved;Income;Individual;Information Dissemination;Institution;Intervention;Leadership;Mentors;Mission;New Mexico;novel strategies;Office of Administrative Management;Outcome;Participant;Peer Review;Phase;Procedures;Program Evaluation;programs;Recovery;repaired;Reporting;Research;Research Personnel;Resources;Role;scientific hub;Series;skills;Source;Strategic Planning;Study Section;success;Talents;Training;Training Programs;United States National Institutes of Health;Universities;Work;Writing

PROJECT_TITLE: Administrative Core Component 1


NIH_SPENDING_CATS: Bioengineering;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Disability Research;Neurosciences;Physical Injury - Accidents and Adverse Effects

PHR: PROJECT NARRATIVE  The Clinical Core supports the goals of the Center for Brain Recovery and Repair by providing an essential  resource to support studies with human subjects. The Clinical Core serves as a centrally-located Human  Subjects research hub that provides expert consultation, mentoring/training, cutting-edge instrumentation and  technical support for Project Leads and other clinical neuroscience investigators. These efforts will advance  inventions and treatments that will reduce disabilities and improve outcomes for brain injury survivors and their  families.

PI_NAMEs: RICHARDSON, JESSICA D (contact)

PROJECT_TERMS: Acceleration;Acute;Acute Brain Injuries;Affect;Applications Grants;Area;base;Behavioral;Brain;Brain Diseases;Brain Injuries;brain research;career;Cause of Death;Chronic;Chronic Brain Injury;Clinical;clinical investigation;Clinical Investigator;Clinical Research;Clinical Trials;cohort;Collaborations;collaborative environment;Communities;Computer software;Consultations;Core Facility;Data;Data Collection;data management;Development;Devices;Diagnostic;Disability outcome;Educational workshop;Electroencephalography;Electrophysiology (science);Emerging Technologies;Ensure;Environment;Equipment;equipment acquisition;Family;Fee-for-Service Plans;Feedback;Fostering;Funding;Future;Goals;Good Clinical Practice;Grant;Human;human subject;Human Subject Research;improved;improved outcome;Income;Individual;Injury;injury and repair;injury recovery;innovation;Inpatients;Institution;Institutional Review Boards;instrumentation;Intensive Care;Intensive Care Units;interdisciplinary collaboration;Interdisciplinary Study;Intervention;invention;investigator training;Investments;Leadership;life span;Long term disability;Maintenance;Manuscripts;Measures;member;Mentors;Methodology;Methods;Modeling;Monitor;Names;neural circuit;Neurodevelopmental Disorder;neuroimaging;Neurologic;Neuropsychology;neuroregulation;Neurosciences;Neurosciences Research;New Mexico;novel;novel therapeutics;operation;Outcome;Outpatients;outreach;Patient Recruitments;Phase;pre-clinical;Preparation;Procedures;Program Research Project Grants;programs;Quality of life;Recovery;recruit;repaired;Reporting;Reproducibility of Results;Research;Research Design;Research Methodology;Research Personnel;Research Project Grants;Research Support;Resources;Role;Safety;Schedule;Science;Services;Severities;societal costs;Stream;success;Survivors;System;Technology;Testing;Therapeutic;therapeutic target;Training;trend;trial design;Universities;user-friendly

PROJECT_TITLE: Human Subjects Clinical Core Component 2


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Bioengineering;Emerging Infectious Diseases;Infectious Diseases;Nanotechnology;Wound Healing and Care

ORG_CITY: HADLEY

ORG_NAME: UNIVERSITY OF MASSACHUSETTS AMHERST

PHR: Project Narrative The goal of the proposed research is to develop antimicrobial nanomaterials for the treatment of wound biofilm infections. These challenging infections occur across the population, and, in particular, in the elderly and those with underlying diseases. This proposed study will impact the rapidly emerging threat of multidrug resistant bacterial infections, providing an alternative to surgical methods currently in use.

PI_NAMEs: PATEL, ROBIN ;ROTELLO, VINCENT M. (contact)

PROGRAM_OFFICER_NAME: XU, ZUOYU

PROJECT_TERMS: Acinetobacter baumannii;Adhesions;Affect;Anti-Bacterial Agents;anti-microbial drug;Antibiotic Therapy;Antibiotics;antimicrobial;Architecture;Bacteria;Bacterial Counts;Bacterial Drug Resistance;Bacterial Infections;bactericide;Biocompatible Materials;Biological Assay;biomaterial compatibility;Cells;Charge;chronic infection;chronic wound;Clinical Treatment;Coculture Techniques;controlled release;copolymer;cost;Coupled;crosslink;design;di-block copolymer;Disease;Dose;Drug resistance;Elderly;Emulsions;Engineering;Environment;Excision;experimental study;extracellular;Foundations;Gel;Goals;healing;Hydrogels;Hydrophobicity;Immune response;In Vitro;in vitro activity;in vitro testing;in vivo;in vivo evaluation;Infection;Infiltration;luminescence;Mammalian Cell;methicillin resistant Staphylococcus aureus;Methods;Microbial Biofilms;Modeling;Multi-Drug Resistance;Mus;nanoDroplet;nanoemulsion;nanomaterials;nanomedicine;nanoparticle;nanopolymer;Nature;new therapeutic target;Oils;Operative Surgical Procedures;Outcome;particle;Pathogenicity;Penetration;Persons;Phytochemical;Polymers;Population;preclinical evaluation;Refractory;Research;Resistance;scaffold;self assembly;Serial Passage;Sterile coverings;Surface Properties;System;Testing;Therapeutic;Tissues;Toxic effect;uptake;Video Microscopy;Volatile Oils;wound;wound biofilm;wound dressing;wound environment;wound healing;Wound Infection;Wound models;wound treatment

PROJECT_TITLE: Engineered Polymer Nanoemulsions for Treatment of Wound Biofilm Infections

STUDY_SECTION: NANO

STUDY_SECTION_NAME: Nanotechnology Study Section[NANO]


NIH_SPENDING_CATS: Bioengineering;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Neurosciences

PHR: The Preclinical Core is a centralized resource that provides expertise, training and instrumentation to Project Leads and other investigators to accelerate discovery of new treatments for brain injury survivors. The Preclinical Core supports the goals of the Center for Brain Recovery and Repair by providing an essential resource for developing new therapeutic avenues for improving function after brain injury.

PI_NAMEs: CUNNINGHAM, LEE ANNA (contact)

PROJECT_TERMS: Acceleration;addiction;alcohol exposure;alcohol research;Anatomy;Applications Grants;Area;base;Behavior;behavior test;Behavioral;Biological Assay;Brain;Brain Injuries;brain repair;Budgets;Clinical Investigator;cohort;Collaborations;Communities;Comprehensive Cancer Center;Computer software;confocal imaging;Consultations;cost;Data;design;Development;Documentation;Educational workshop;Electroencephalography;Ensure;Equipment;Experimental Designs;Fee-for-Service Plans;Fees;Fostering;functional improvement;Funding;Future;Goals;Grant;Image;Image Analysis;improved;Income;innovation;instrumentation;Interdisciplinary Study;investigator training;Investments;Laboratory Research;Malignant neoplasm of brain;man;Measures;Mentorship;Methodology;Methods;Mission;multidisciplinary;National Institute on Alcohol Abuse and Alcoholism;Nervous System Disorder;neural;Neuroanatomy;Neurologic;Neurology;neurophysiology;Neurosciences;Neurosciences Research;neurosurgery;New Mexico;novel therapeutics;Outcome;outreach;Performance;Phase;Physiological;Play;pre-clinical;Pre-Clinical Model;pre-clinical research;Procedures;programs;Recovery;repaired;Reproducibility;Research;Research Design;research facility;Research Institute;Research Personnel;Research Project Grants;Research Support;Resolution;Resources;Rodent;Rodent Model;Role;Scanning;Schedule;Scientist;Site;Speed;Stroke;Structure;success;Survivors;System;Technical Expertise;touchscreen;Training;translational impact;Translational Research;United States National Institutes of Health;Universities;Wing

PROJECT_TITLE: Preclinical Core Component 3


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research

ORG_CITY: LA JOLLA

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative Spontaneous speech patterns and time-pressured picture naming ability have been shown to predict who may eventually develop Alzheimer’s Disease, but to date, these patterns have only been identified in monolinguals. As the country diversifies, the aging population will include many more people who speak two or more languages which makes the assessment of dementia inherently more complex. The proposed research will investigate linguistic markers of future cognitive decline and cognitive ability in older Spanish-English bilinguals to determine which aspects of bilingual speech might be useful in early diagnosis of AD in a more diverse demographic than previously studied.

PI_NAMEs: GARCIA, DALIA  (contact)

PROGRAM_OFFICER_NAME: TORRES, DELANY

PROJECT_TERMS: Affect;Aging;aging population;Alzheimer disease detection;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease patient;Alzheimer’s disease biomarker;American;Amyloid deposition;archived data;Archives;Attention;bilingualism;career;Censuses;Clinical;Cognition;Cognitive;cognitive ability;cognitive function;cognitive testing;Complex;Consensus;Country;Cross-Sectional Studies;Dementia;dementia risk;density;Development;Diagnosis;Disease Management;Disease Progression;Early Diagnosis;Early identification;Elderly;Episodic memory;executive function;Exhibits;expectation;field study;Filler;Formulation;Frequencies;Future;Genetic Transcription;graduate school;Impaired cognition;improved;Interview;Knowledge;Language;language impairment;language processing;Lead;lexical;Linguistics;Longitudinal Studies;Measures;Memory;Methods;Minority Status;Modeling;Names;Neurobehavioral Manifestations;Neuropsychological Tests;non-demented;novel;Oral;Pathologist;Pattern;Performance;Persons;Population;pre-clinical;pressure;prevent;Probability;Procedures;prodromal Alzheimer's disease;Production;Productivity;prospective;Psycholinguistics;recruit;Research;Research Project Grants;Retrieval;Role;Semantics;skills;Spanish;Spanish/English;Speech;Structure;syntax;Testing;theories;Time;Training;Transcript;Visuospatial

PROJECT_TITLE: Speech Markers of Cognition in Aging Bilingualism


ORG_CITY: CHESTNUT HILL

ORG_DEPT: BIOLOGY

ORG_NAME: BOSTON COLLEGE

PHR: Project Narrative A specialized CNS macrophage, the perivascular macrophage is the target of HIV and SIV early following infection in the periphery and throughout infection even with non-detectable ART. SPION labels injection into the CSF label the PV macrophages and show they can leave the CNS, via draining lymphatics potentially reseeding the periphery with CNS derived virus. Studies in this application propose to use an FDA approved reagent to target PV macrophages, that ablates these cells, and study ask whether such ablation with ART and ART cessation, clears this CNS reservoir and its ability to traffic to the periphery with CNS derived viral sequences.

PI_NAMEs: KIM, WOONG-KI ;WILLIAMS, KENNETH C (contact)

PROGRAM_OFFICER_NAME: DALEY, WILLIAM PATRICK

PROJECT_TERMS: Ablation;Address;animal tissue;Animals;antiretroviral therapy;Binding;Blood Vessels;Bone Marrow;Brain;Cells;Cerebrospinal Fluid;Cervical;Color;deep sequencing;DNA;draining lymph node;Emigrations;Engraftment;FDA approved;HIV;immunoreactivity;Individual;Infection;inhibitor;Injections;Interruption;iron oxide nanoparticle;Label;Lymph;Lymphatic;lymphatic drainage;Macaca;Macrophage;Macrophage Colony-Stimulating Factor Receptor;migration;Monkeys;Myeloid Cells;Pathway interactions;Patients;Peripheral;Plasma;Population;prevent;Productivity;Reagent;Residual state;RNA;Role;SIV;Source;Spinal Ganglia;Spleen;superparamagnetism;Testing;Tissues;trafficking;Viral;viral DNA;viral rebound;Viral reservoir;Viremia;Virus

PROJECT_TITLE: Effects of CSF1R Blockade on Repopulation of SIV Reservoirs from the CNS to the Periphery After Antiretroviral Therapy Interruption


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Aging;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Emerging Infectious Diseases;Heart Disease;Hypertension;Infectious Diseases;Lead Poisoning;Prevention;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: NARRATIVE: The K24 proposal will support Dr. Margaret McNairy to train clinical investigators in the conduct of patient-oriented cardiovascular disease research in Haiti and Tanzania, and to conduct a new study on environmental lead exposure and cardiovascular disease risk factors in Haiti. United States trainees will spend ~60% of their time at international research sites in Haiti or Tanzania, which have onsite Weill Cornell faculty, long-standing international collaborators, and outstanding environments for research training. All the projects have patient-oriented research on cardiovascular disease as their focus and offer trainees a broad experience in the conduct of mentored research in the topics of cardiovascular epidemiology, clinical trials and implementation science.

PI_NAMEs: MCNAIRY, MARGARET LEIGHTON (contact)

PROGRAM_OFFICER_NAME: SMITH, SHARON M

PROJECT_TERMS: 2019-nCoV;Adult;Amlodipine;Anti-Hypertensive Agents;Area;biobank;Blood;blood lead;Blood Pressure;Blood Screening;Cardiac;Cardiac Death;Cardiovascular Diseases;cardiovascular disorder epidemiology;cardiovascular disorder risk;Caring;Case/Control Studies;Cessation of life;Clinic;Clinical;clinical epidemiology;clinical implementation;Clinical Investigator;Clinical Trials;cohort;Cohort Studies;Communicable Diseases;Communities;Consumption;COVID-19;COVID-19 complications;Data;design;Development;Diabetes Mellitus;Diastolic blood pressure;Disease;early phase clinical trial;Early treatment;Echocardiography;Environment;environmental Pb exposure;Event;experience;Faculty;Family;Fellowship;Foundations;Functional disorder;Funding;Future;General Population;global health;Goals;Haiti;Haitian;Health;Heart failure;HIV;Hypertension;hypertension control;hypertension treatment;hypertensive;immune activation;implementation evaluation;implementation science;improved;Incidence;Inflammation;International;Intervention;Kidney Diseases;kidney dysfunction;Laboratories;Lead;Lead levels;Leadership;Learning;Longitudinal cohort;low income country;Mass Spectrum Analysis;medication compliance;Mentors;Mentorship;Mid-Career Clinical Scientist Award (K24);mortality;Myocardial dysfunction;Myocardial Infarction;National Heart, Lung, and Blood Institute;National Institute of Allergy and Infectious Disease;Natural History;Obesity;occupational lead exposure;Outcome;Participant;patient oriented;patient oriented research;Persons;physical inactivity;Population;Postdoctoral Fellow;Poverty;prehypertension;premature;Prevalence;Prevention;primary outcome;programs;Randomized;randomized trial;randomized, clinical trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;Recording of previous events;Research;Research Project Grants;Research Training;Risk Factors;Role;Safety;screening;Serology;Severities;Site;Smoking;social determinants;Sodium;Sodium Chloride;Source;Spottings;standard care;stool sample;Stroke;Tanzania;Testing;Time;Training;training opportunity;Training Programs;training project;Tuberculosis;Unhealthy Diet;United States;Urine;Woman

PROJECT_TITLE: Global Health Research and Training in Cardiovascular Disease

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(JA)]


NIH_SPENDING_CATS: Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Epilepsy;Neurodegenerative;Neurosciences;Sleep Research

PI_NAMEs: MCKENZIE, SAMUEL ARNOLD (contact)

PROJECT_TERMS: Acetylcholine;Affect;Anticonvulsants;Binding;Brain;Brain region;Cell Nucleus;cholinergic;Chronic;Clinical Research;Databases;Electric Stimulation;Electrophysiology (science);Epilepsy;experimental study;Future;Hippocampus;Injections;Kainic Acid;Link;Midbrain structure;Modeling;Neocortex;neural;Neurons;neurophysiology;neuroprotection;New Mexico;Optics;Patients;Pattern;prevent;Protocols documentation;rapid eye movement;Rattus;Reaction;Recovery;REM Sleep;repaired;Seizures;Signal Transduction;Sleep;Testing;Thalamic structure;Therapeutic;Universities

PROJECT_TITLE: A rat model of responsive neural treatment for epilepsy


ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

PHR: Project Narrative The objective of this preclinical study is to investigate the molecular mechanism and therapeutic efficacy of SUMO1 small molecule degraders in treatment of advanced stage III and IV metastatic colon cancers, alone and in combination with the standard chemotherapy.

PI_NAMEs: BELLAIL, ANITA  (contact)

PROGRAM_OFFICER_NAME: CHEN, WEIWEI

PROJECT_TERMS: 3-Dimensional;Affinity;anticancer activity;Antineoplastic Agents;beta catenin;Binding;Binding Proteins;Biological Markers;BRAF gene;cancer cell;Cancer Model;Cessation of life;Chemicals;chemotherapy;Clinical Treatment;colon cancer cell line;colon cancer patients;colon cancer treatment;Colon Carcinoma;Complex;CRISPR screen;CRISPR/Cas technology;CUL1 gene;Cytoplasm;Data;Development;Diagnosis;Dose;drug action;Drug Screening;Drug Targeting;effective therapy;efficacious treatment;Enzymes;Event;Foundations;Genes;Genetic Transcription;genome wide screen;genome-wide;Genomics;Glucosephosphate Dehydrogenase;Glycolysis;Goals;Human;human disease;in vivo evaluation;Interferometry;Invaded;Investigation;KRAS2 gene;Lead;Ligase;Lipids;Liquid Chromatography;Mediating;Metabolic;metabolomics;metastatic colorectal;Metastatic Neoplasm to the Liver;Modification;Molecular;mouse model;Mus;Mutation;No-Observed-Adverse-Effect Level;novel;Nuclear Magnetic Resonance;Organ;Organoids;Pathway interactions;patient derived xenograft model;Patients;PF4 Gene;Pharmaceutical Preparations;pharmacologic;Pharmacotherapy;Plasma;pre-clinical;preclinical study;Proliferating;Proteins;Recombinants;recruit;refractory cancer;Resistance;small molecule;Solid;Sumoylation Pathway;tandem mass spectrometry;TCF7L2 gene;Tertiary Protein Structure;Testing;therapeutically effective;Toxic effect;Toxicology;transcription factor;Treatment Efficacy;Tumor Burden;Ubiquitin;ubiquitin ligase;ubiquitin-protein ligase;Ubiquitination

PROJECT_TITLE: Targeting SUMO1 degradation for advanced colon cancer therapy


ORG_DEPT: EMERGENCY MEDICINE

PHR: Project Narrative Ischemic stroke is a devastating neurological disease affecting millions of Americans. There is now an urgent need to understand the underlying mechanisms of stroke brain injury and to develop therapeutics against stroke brain injury. This proposal will use state-of-the-art animal models to study the role of the endolysosomal system in stroke brain injury.

PI_NAMEs: HU, BINGREN  (contact)

PROJECT_TERMS: Abbreviations;Affect;American;Animal Model;ATP phosphohydrolase;Autophagosome;Brain;Brain Injuries;Brain Ischemia;Cathepsins;Cathepsins B;Cell Death;Cell Membrane Permeability;Cells;cytokine;Cytoplasm;Cytosol;Development;Disease;Early Endosome;Encephalitis;Endopeptidases;Endosomes;Enzymes;Ethylmaleimide;Event;Exhibits;Extracellular Space;Family member;Golgi Apparatus;Hybrids;I Kappa B-Alpha;Inflammasome;Inflammation;Inflammation Mediators;Inflammatory;Inflammatory Response;Injury;Ischemia;Ischemic Brain Injury;Ischemic Stroke;Knock-out;Knockout Mice;late endosome;Lysosomes;Macrophage;Mediating;Microglia;migration;Modeling;mouse model;Mus;N-ethylmaleimide-sensitive protein;Nervous System Disorder;neuron loss;Neurons;neuropathology;new therapeutic target;NF-kappa B;novel;Outer Mitochondrial Membrane;overexpression;Pathologic;Pathway interactions;Pattern;Phenotype;Process;Protein Deficiency;Proteins;Replacement Therapy;Research;Role;Rupture;Site;Stroke;Structural Protein;Structure;Suicide;System;Testing;Therapeutic;Tissues;Transgenic Mice;wasting

PROJECT_TITLE: The Role of Lysosomal Membrane Permeabilization and Cathepsin B Release in Stroke Brain Injury

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


NIH_SPENDING_CATS: Bioengineering;Biotechnology

ORG_CITY: CLEMSON

ORG_NAME: CLEMSON UNIVERSITY

ORG_STATE: SC

PHR: Project Narrative Exosomes are now fully realized as being integral elements in many biological processes, first and foremost as conduits for inter-cellular communication. Key to their study and utilization across fundamental biochemistry, potential uses in clinical diagnostics, and realizing their promise as therapeutic drug delivery vehicles is the development of technologies that allow their rigorous, robust, efficient and inexpensive isolation and purification across many size scales and source matrices. Capillary-channeled polymer (C-CP) fiber and film platforms address these challenges in a unified way that provides continuity and simplicity across these fields of endeavor, holding the promise of advancing the knowledge base and applications of these important extracellular vesicles.

PI_NAMEs: BRUCE, TERRI LANE FOSTER;MARCUS, RICHARD KENNETH (contact)

PROGRAM_OFFICER_NAME: SALVADOR MORALES, CAROLINA

PROJECT_TERMS: 3D Print;Address;Affect;Aliquot;Antibodies;aptamer;base;Basic Science;Benchmarking;Biochemistry;Biological;Biological Assay;Biological Markers;Biological Process;Blood capillaries;Cell Culture Techniques;Cell Line;cell type;Cells;Cellular biology;Characteristics;Chemicals;Clinical;clinical diagnosis;clinical diagnostics;Column Chromatography;Communication;Communities;Complex;cost;cost effective;Coupled;Culture Media;delivery vehicle;design;Development;Diagnosis;Diagnostic tests;Diameter;Disease;disease diagnostic;Drug Delivery Systems;Elements;Environment;Ethylenes;Exhibits;exosome;Experimental Models;extracellular vesicles;Fiber;Film;fluid flow;fundamental research;Harvest;High Pressure Liquid Chromatography;Home;Image;Immobilization;Immunoassay;instrumentation;intercellular communication;interest;knowledge base;Laboratories;Lateral;Liquid substance;Membrane Proteins;meter;Methodology;Methods;new technology;novel;parallel processing;peer;Performance;Permeability;Phase;Plasma;Polymers;Population;Positron-Emission Tomography;Program Development;programs;protein biomarkers;Proteins;Proteomics;prototype;Provider;Rapid diagnostics;Recovery;Reproducibility;Research;research and development;Sampling;Scientific Evaluation;Shapes;Source;Surface;System;technology development;technology platform;terephthalate;Therapeutic;transcriptome sequencing;Urine;Validation;vector;Vesicle;Virion;Western Blotting

PROJECT_TITLE: Capillary-channeled polymers fibers and films - A platform technology for exosome isolation and analytics

STUDY_SECTION: ISD

STUDY_SECTION_NAME: Instrumentation and Systems Development Study Section[ISD]


NIH_SPENDING_CATS: Behavioral and Social Science;Biomedical Imaging;Brain Cancer;Brain Disorders;Cancer;Cerebrovascular;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Radiation Oncology;Rare Diseases

ORG_CITY: IRVINE

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: PROJECT NARRATIVE  Radiotherapy remains a frontline treatment for childhood medulloblastoma (MB) where long-term survival in  the majority of patients (> 80%) is accompanied by debilitating cognitive and cerebrovascular side effects. The  proposed R01 seeks to evaluate the benefit of FLASH for the treatment of MB, a new ultra-high dose rate  radiation modality that greatly minimizes normal tissue toxicities without compromising the eradication of brain  tumors when compared to conventional dose rate radiation protocols currently used in the clinic. This project  involves studies approximating clinical treatments of MB using a relevant grade 3 MB tumor orthotopically  implanted in the brain of mice as well as tumor free animals. Mice subjected to each radiation modality will be  evaluated at short (1-month) and long-term (4-6 month) post-irradiation times for tumor control,  neurocognitive, cerebrovascular and molecular outcomes to provide clinical and mechanistic insight into the  neuroprotective effects of FLASH.

PI_NAMEs: LIMOLI, CHARLES  (contact)

PROGRAM_OFFICER_NAME: PRASANNA, PAT G

PROJECT_TERMS: Adolescent;Animals;arm;astrogliosis;Attention;Behavior;Behavioral;Blood Vessels;Brain;Brain Neoplasms;Cephalic;cerebral microbleeds;cerebrovascular;chemotherapy;Child;Childhood;Childhood Brain Neoplasm;Childhood Medulloblastomas;Cisplatin;Classification;Clinic;Clinical;Clinical Management;clinical practice;clinical translation;Clinical Treatment;clinically relevant;Cognitive;Cognitive deficits;cognitive function;cohort;comparison control;cone-beam computed tomography;contrast enhanced;conventional dosing;Cranial Irradiation;Data;density;Diagnosis;Disease;Dose Rate;executive function;Exhibits;Exposure to;Female;Fractionation;Functional disorder;Gliosis;Goals;Hippocampus;Human;Image;Immunocompromised Host;Impaired cognition;Impairment;Implant;improved;Injections;innovation;insight;Ionizing radiation;irradiation;Lead;Learning;Light;Link;Longterm Follow-up;Magnetic Resonance Imaging;male;Malignant Childhood Neoplasm;Malignant neoplasm of brain;Medulloblastoma;medulloblastoma cell line;Memory;Methods;Modality;Modeling;Molecular;Monitor;Mood Disorders;Morbidity - disease rate;Mus;myelination;Necrosis;neoplastic cell;nerve stem cell;Neurocognitive;neurogenesis;neuroinflammation;Neurologic;neuroprotection;neurotoxic;Normal tissue morphology;novel;Nude Mice;Outcome;Pathology;Patients;Pediatric Oncology;pediatric patients;Performance;Physiologic pulse;Posterior Fossa;pre-clinical;Precision therapeutics;preclinical study;preservation;Prevalence;Prognosis;Protocols documentation;Quality of life;Radiation;radiation effect;Radiation therapy;Radiation Tolerance;Radiation Toxicity;radiation-induced cognitive dysfunction;Regimen;response;Series;side effect;Spinal;stem cells;stroke risk;Structure;Survival Rate;Survivors;Technology;Testing;therapy outcome;Time;Toxic effect;Translating;tumor;tumor growth;Tumor Tissue;vascular abnormality;Vertebral column;white matter;X-Ray Computed Tomography

PROJECT_TITLE: Improving pediatric brain tumor treatments using FLASH radiotherapy

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Aging;Assistive Technology;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Clinical Research;Disability Research;Hearing Loss;Neurosciences;Rehabilitation

ORG_CITY: MINNEAPOLIS

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE This project investigates the perception and neural coding of pitch in infants, as well as in adults throughout the lifespan with normal and impaired hearing. Pitch plays a crucial role in music and speech perception, and in enabling us to hear out one voice in the presence of other competing sounds. An improved understanding of how pitch is coded should lead to better hearing aids and auditory implants, which will help people with hearing disabilities communicate more effectively.

PI_NAMEs: OXENHAM, ANDREW J. (contact)

PROGRAM_OFFICER_NAME: KING, KELLY ANNE

PROJECT_TERMS: Acoustic Nerve;Acoustics;Adult;Affect;Age;age effect;age related;Aging;Animals;Area;Auditory;Auditory area;Auditory Perception;Auditory system;Basilar Membrane;Behavior;Behavioral;behavioral study;Bilateral;Cochlear Hearing Loss;Cochlear Implants;cochlear synaptopathy;Code;Communication;Communication Disability;Complex;Computer Models;Consensus;cortex mapping;Cues;Development;Dimensions;Dissociation;Electroencephalography;Environment;experience;experimental study;Exposure to;Frequencies;Functional Magnetic Resonance Imaging;Goals;Grouping;Hearing;Hearing Aids;hearing disability;hearing impairment;Human;Implant;improved;Individual Differences;Infant;Judgment;Language;Lead;Learning;lexical;life span;Maps;Measures;Mediating;Music;neural;neuroimaging;neurophysiology;normal hearing;novel strategies;Perception;Performance;Peripheral;Persons;Phase;Pitch Discrimination;Pitch Perception;Play;Process;Property;Research;Resolution;response;Role;Running;segregation;Signal Transduction;sound;sound frequency;Speech;Speech Perception;statistical learning;statistics;Stimulus;Structure;success;Testing;theories;trait;two-dimensional;Variant;Work

PROJECT_TITLE: Complex pitch perception in complex environments

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


NIH_SPENDING_CATS: Cancer;Skin Cancer

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: PROJECT NARRATIVE The tumor microenvironment plays a critical role in melanoma proliferation and invasion. Keratinocytes are the most abundant cells in the microenvironment of early-stage melanomas, but their role is poorly characterized in vivo. This study aims to elucidate the role of microenvironmental keratinocytes in melanoma progression in vivo by examining the effect of keratinocyte adhesion and paracrine signaling.

PI_NAMEs: MA, YILUN  (contact)

PROGRAM_OFFICER_NAME: PURI, ANU

PROJECT_TERMS: Adhesions;Affect;Animal Model;Brain-Derived Neurotrophic Factor;Cell Communication;cell motility;cell type;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Data;Development;Electroporation;Endothelin;Epidermis;epithelial to mesenchymal transition;Growth;Growth Factor;Histology;Human;human tissue;Image;In Vitro;in vivo;in vivo imaging;Individual;insight;interest;Invaded;keratinocyte;Knock-out;Label;Melanins;melanocyte;Melanoma;Melanoma Cell;Melanosomes;member;Methods;migration;Modeling;Morphology;Neoplasm Metastasis;paracrine;Paracrine Communication;Patient-Focused Outcomes;Physical Restraint;Physiology;Pigments;Play;programs;Proliferating;promoter;Proteins;Quantitative Reverse Transcriptase PCR;Regulation;Resolution;restraint;Role;Skin;Skin Cancer;Stratum Basale;System;Testing;Tissue Sample;Tissues;tool;transcription factor;transcriptome;Transgenic Organisms;tumor;Tumor Expansion;tumor microenvironment;tumor progression;tumorigenic;Ultraviolet Rays;Up-Regulation;Western Blotting;Zebrafish

PROJECT_TITLE: In vivo characterization of keratinocytes in the melanoma microenvironment


ED_INST_TYPE: HOSPITALS

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: PROJECT NARRATIVE  Lung cancer is the global leader in cancer related deaths, and responsible for an estimated 1.4 million deaths worldwide and ~160,000 deaths in the United States annually. Treatment outcomes have improved in recent years with our recent understanding that patients can be divided into subsets based on the presence of specific genetic mutations occurring in their tumors that can be targeted with certain specific therapeutics. This application proposes the analysis of mechanisms that drive lethal lung cancer progression, using genetic mouse experimental models of lung cancer.

PI_NAMEs: VAISHNAVI, ARIA  (contact)

PROGRAM_OFFICER_NAME: FORRY, SUZANNE L

PROJECT_TERMS: 3-Dimensional;Acceleration;acquired drug resistance;Alleles;BRAF gene;Cancer Biology;cancer initiation;Cancer Patient;Cell Line;Cells;Cessation of life;Clinic;Clinical;Complementary DNA;CRISPR/Cas technology;Disease;Disease Progression;Disease Resistance;DNA Sequence Alteration;Dominant-Negative Mutation;Drug resistance;EGFR gene;Epidermal Growth Factor Receptor;established cell line;Experimental Models;Family member;gain of function;Genetic;Genetic Transcription;Genetically Engineered Mouse;genome editing;Goals;Heterogeneity;improved;In Vitro;in vitro Model;in vivo;KRAS2 gene;KRASG12D;loss of function;Lung;Lung Neoplasms;Maintenance;Malignant - descriptor;Malignant neoplasm of lung;Malignant Neoplasms;Mediating;Modeling;Molecular;molecular subtypes;molecular targeted therapies;Monitor;mouse model;Mus;Mutation;neoplastic cell;Non-Small-Cell Lung Carcinoma;Oncogenes;Oncogenic;Organoids;overexpression;patient derived xenograft model;patient stratification;Patients;personalized medicine;Phosphotransferases;Population;predictive marker;programs;Proliferating;Receptor Signaling;recruit;Refractory;Reporting;Research;Research Personnel;Residual Neoplasm;Resistance;response;Role;scaffold;Signal Transduction;single-cell RNA sequencing;spatiotemporal;Structure;success;System;targeted biomarker;targeted treatment;Technology;Testing;Therapeutic;Time;Treatment outcome;treatment response;treatment strategy;tumor;Tumor Burden;tumor heterogeneity;tumor initiation;Tumor Markers;tumor progression;tumorigenesis;United States;War;Work;Xenograft Model

PROJECT_TITLE: Elucidating the role of support signaling in promoting minimal residual disease in mouse models of oncogene-driven lung cancer


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Bioengineering;Rare Diseases

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: Project Narrative Muscle contraction is reliant upon excitation-contraction coupling (ECC) process that leads to an increase in cytosolic Ca2+ concentration and its subsequent binding to contractile proteins. Several neuromuscular disorders including Central Core Disease, Multiminicore Disease, Malignant Hyperthermia, Hypokalemic Periodic Paralysis are related to defects in the ECC process resulting in abnormal Ca2+ levels. Our studies will provide pivotal structural insights into the molecular mechanisms of ECC, that is ultimately required for finding new cures for neuromuscular diseases.

PI_NAMEs: SERYSHEVA, IRINA I (contact)

PROGRAM_OFFICER_NAME: LINDHURST, MARJORIE JEAN

PROJECT_TERMS: 3-Dimensional;Address;Affect;Architecture;Binding;Biochemical;Cell membrane;Cellular Membrane;Central Core Myopathy;Complex;Contractile Proteins;convolutional neural network;Coupled;Coupling;Crowding;Cryoelectron Microscopy;cryogenics;Cytoplasm;Data;Data Collection;Defect;Detergents;Dihydropyridine Receptors;disease model;drug discovery;electron tomography;Electrons;Elements;Environment;Event;Foundations;Freezing;Functional disorder;Future;genetic regulatory protein;Geometry;Goals;Hydration status;Hypokalemic periodic paralysis;Image;Image Analysis;Impairment;In Situ;insight;Integral Membrane Protein;Ions;Knowledge;Link;Lipid Bilayers;Location;Malignant hyperpyrexia due to anesthesia;Measurement;Membrane;Membrane Lipids;Methodology;Molecular;Morphologic artifacts;Multiminicore disease;Multiprotein Complexes;Muscle;Muscle Cells;Muscle Contraction;Muscle Fibers;Mutation;Myopathy;Neuromuscular Diseases;new therapeutic target;Outcome;particle;Pathologic;Pharmaceutical Preparations;Physiological;Positioning Attribute;Preparation;preservation;Process;protein complex;protein protein interaction;Proteins;Receptor Gene;reconstruction;Regulation;Research;Resolution;Ryanodine Receptor Calcium Release Channel;Sampling;Sarcoplasmic Reticulum;Series;Signal Transduction;Skeletal Muscle;structural determinants;Structure;Techniques;Thick;three dimensional structure;Tomogram;tomography;Visualization;voltage

PROJECT_TITLE: Defining architecture of EC coupling machinery in situ

STUDY_SECTION: SMEP

STUDY_SECTION_NAME: Skeletal Muscle and Exercise Physiology Study Section[SMEP]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

ORG_CITY: Chicago

ORG_NAME: NORTHWESTERN UNIVERSITY

ORG_STATE: IL

PHR: Narrative The activities of this grant represent a major upgrade in the technology to precisely analyze protein molecules from cells and the human body. From model systems and humans, proteins are measured from cell culture, cells, fluids, and solid tissue to better understand and detect mechanisms and markers of human disease. Technological improvements assist the collaborating clinical and research labs directly, but also the field of protein measurement science in general through robust programs for training, dissemination and community engagement.

PI_NAMEs: KELLEHER, NEIL L (contact)

PROGRAM_OFFICER_NAME: BARNES, CHARLES ASHLEY

PROJECT_TERMS: Adopted;age related;age-related disease;American;anti-cancer research;Applications Grants;Area;Automobile Driving;Basic Science;Biological Models;Biology;Biomedical Research;Cancer Biology;Cell Culture Techniques;Cells;Chicago;Clinical;Clinical Research;Collaborations;Communities;community engagement;data streams;Dedications;Development;digital media;Disease;Ensure;Environment;experience;Funding;Future;Generations;Genes;Geographic Distribution;Goals;Grant;Heart Diseases;Human;Human body;human disease;Immunobiology;Immunology;improved;Infrastructure;innovation;Institution;interest;International;Investments;Laboratories;Leadership;Letters;Liquid substance;Mass Spectrum Analysis;Measurement;Measures;Medical Research;Methods;Mission;Modernization;Molecular;National Institute of General Medical Sciences;Neurology;new technology;next generation;operation;Organ Transplantation;Persons;Phase;Policies;Post-Translational Protein Processing;Private Sector;programs;Protein Analysis;Proteins;Proteomics;Research;Research Personnel;Resources;Role;Science;Series;Site;Solid;Specificity;success;synergism;Technology;technology research and development;Tissues;Training;Training Activity;Training Programs;Translating;United States National Institutes of Health;Universities

PROJECT_TITLE: National Resource for Translational and Developmental Proteomics

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-T(40)P]


NIH_SPENDING_CATS: Biotechnology

PROJECT_TERMS: Automobile Driving;Award;Biomedical Research;Biomedical Technology;Communities;community engagement;Country;Dedications;Development;Education;Education and Outreach;Ensure;experience;Goals;Growth;Human Resources;Investments;Laboratories;Leadership;Letters;Life Cycle Stages;magnetic field;Mass Spectrum Analysis;member;Methodology;Methods;Mission;multidisciplinary;operation;Perception;Phase;Procedures;Process;Proteomics;Publications;Qualifying;Research;Resources;Running;sustainable resource;Technology;technology research and development;Training;Universities;Vision

PROJECT_TITLE: Administration

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-T]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Networking and Information Technology R&D (NITRD)

PROJECT_TERMS: Address;Basic Science;biological systems;Buffers;Chromatography;clinical application;Communities;community engagement;Computer software;computerized data processing;Coupled;data acquisition;Data Analyses;Desire for food;Detection;Development;Diameter;Education and Outreach;Encapsulated;experimental study;Fostering;Grant;improved;innovation;innovative technologies;instrument;ion mobility;Ions;Knowledge;Leadership;Learning;Link;mass spectrometer;Mass Spectrum Analysis;Measurement;Methods;Molecular Weight;nano;operation;Optics;Peptides;Performance;Phenotype;Preparation;Process;programs;Protein Analysis;Proteins;Proteomics;Publishing;Research Personnel;Resources;Sampling;Science;skills;Software Tools;Source;Spectrometry;Technology;technology research and development;Time;tool;Translational Research;Update;Visualization

PROJECT_TITLE: TR&D 5: Top-Down for the Masses


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Nutrition;Obesity;Physical Activity;Prevention;Social Determinants of Health

ORG_CITY: ATLANTA

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: EMORY UNIVERSITY

PHR: PROJECT NARRATIVE The COVID-19 pandemic resulted in environmental conditions that may have consequences for obesity and related cardio-metabolic behaviors. The study will (1) measure pre-pandemic to pandemic changes in cardio-metabolic health in adults >1 year after the acute lockdown period, and (2) report the size of these changes for different groups of people, (3) study mechanisms leading to changes in health. The findings will help prioritize public health priorities in the pandemic recovery period.

PI_NAMEs: PATEL, SHIVANI A (contact)

PROGRAM_OFFICER_NAME: COADY, SEAN

PROJECT_TERMS: 2019-nCoV;Acute;Adult;age group;Alcohol consumption;American;American Cancer Society;Area;Behavior;Body Weight Changes;Buffers;cancer prevention;cardiometabolism;caregiving;Characteristics;cohort;Cohort Studies;Communities;Containment;Coronavirus;County;COVID-19 pandemic;COVID-19 pandemic effects;Data;data infrastructure;design;Diet;Dietary intake;Distress;District of Columbia;Dose;Enrollment;Environment;Epidemiology;Equity;Ethnic Origin;experience;Future;Geography;Health;Health behavior;Health Priorities;Health Promotion;Health Status;improved;Income;Individual;infection risk;insight;Institution;Investigation;Job loss;Life;Link;Longitudinal Studies;Measures;Mediator;Medical History;Mobility decline;Natural experiment;Obesity;outcome prediction;pandemic disease;pandemic impact;pandemic response;Participant;Persons;Phase;Physical activity;Policies;Population;Population Characteristics;Population Group;post-pandemic;pre-pandemic;prospective;psychosocial;Psychosocial Factor;public database;public health priorities;Quarantine;Race;Recovery;Reporting;Research Support;resilience;response;Risk;SARS-CoV-2 infection;sedentary;Severities;sex;Sleep;sleep pattern;Social Distance;Social isolation;social vulnerability;Socialization;Socioeconomic Factors;socioeconomics;Surveys;Time;Tobacco use;Unemployment;United States;Urbanicity;US State;Vaccines;Weight;Weight Gain;Work

PROJECT_TITLE: The Impact of the COVID-19 Pandemic Environment on Cardiometabolic Health

STUDY_SECTION: LHB

STUDY_SECTION_NAME: Lifestyle and Health Behaviors Study Section[LHB]


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: GAINESVILLE

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: PROJECT NARRATIVE Glioblastoma is an aggressive, fast-growing brain cancer that represents 48% of all malignant brain tumors. Due to the high rate of recurrence, current treatment options only extend survival following initial diagnosis to one year. Building on significant basic research into the biology of glioblastoma identifying myosin 10 as a potential therapeutic target, an interdisciplinary team has been brought together with the necessary expertise in glioblastoma and myosin biology, drug discovery and development, and the clinical treatment of glioblastoma to identify and optimize a myosin 10-based therapeutic agent for glioblastoma therapy.

PI_NAMEs: KAMENECKA, THEODORE M;MILLER, COURTNEY A (contact);RUMBAUGH, GAVIN R;SCAMPAVIA, LOUIS DANIEL;SPICER, TIMOTHY PATRICK;SWEENEY, H LEE

PROGRAM_OFFICER_NAME: ROOF, REBECCA

PROJECT_TERMS: Actins;antitumor effect;Area;ATP Hydrolysis;ATP phosphohydrolase;ATP-G-actin;Basic Science;Binding Proteins;Biochemical;biological adaptation to stress;Biological Assay;Biology;Brain;Cells;Chemicals;cheminformatics;chemotherapy;Chemotherapy and/or radiation;Clinical Treatment;counterscreen;cytotoxicity;Data;Dependence;Development;Diagnosis;DNA Damage;Dose;drug development;drug discovery;Drug Kinetics;drug metabolism;effective therapy;Excision;FDA approved;Funding Mechanisms;Future;Glioblastoma;Goals;Hand;high throughput screening;Human;Impairment;In Vitro;in vivo;Industrialization;inhibitor;inorganic phosphate;Institution;interest;Invaded;Lead;lead optimization;Left;Libraries;Malignant neoplasm of brain;Malignant Neoplasms;Measures;Metabolic stress;Microsomes;Miniaturization;miniaturize;Molecular;Molecular Motors;Molecular Probes;mouse model;Myosin ATPase;Myosin Type II;neoplastic cell;Nonmuscle Myosin Type IIA;novel;Patients;Penetrance;Penetration;Pharmaceutical Chemistry;pharmacologic;pharmacophore;Phase;Plasma Proteins;Preclinical Testing;prevent;Process;Productivity;Proliferating;Property;Readiness;Recurrence;Reproducibility;Research;Research Personnel;response;Robotics;Running;scaffold;screening;Skeletal Muscle Myosins;small molecule;small molecule inhibitor;Solubility;Specificity;standard of care;Structure-Activity Relationship;synergism;targeted treatment;Testing;Therapeutic;Therapeutic Agents;therapeutic target;Titrations;Toxic effect;translational potential;tumor;Work

PROJECT_TITLE: Drug Discovery for First-In-Class Myosin 10 Inhibitors as a Novel Target for Glioblastoma

STUDY_SECTION: NSD

STUDY_SECTION_NAME: Neurological Sciences and Disorders A Study Section[NSD-A]


PROJECT_TERMS: Antibodies;Biological Assay;biological systems;Biology;Capillary Electrophoresis;Cells;cohort;Communities;Computer software;computerized data processing;Data;Dedications;Development;Disease;empowerment;experience;experimental study;follow-up;Foundations;Future;Grant;high throughput screening;Immunoprecipitation;improved;Individual;innovation;insight;interest;Investigation;Investments;Ions;knowledgebase;Liquid Chromatography;Measurement;member;Methods;Modality;Monitor;Pathway interactions;Population;Process;Proteins;Proteomics;Protocols documentation;Rapid screening;Reaction;Reporting;Research;Resources;Sampling;software development;Software Tools;Specific qualifier value;System;Technology;technology research and development;tool;Translating;translational proteomics;Validation;web site

PROJECT_TITLE: TR&D 6: Targeted Top Down


PROJECT_TERMS: Ablation;Basic Science;Biological;Biological Assay;biological research;Biology;Brain;brain tissue;Capillary Electrophoresis;Cell Separation;cell type;Cells;cellular targeting;Clinical;Clinical Research;Collecting Cell;Communities;Data;Dedications;design;Detection;Development;Diameter;Disease;DNA Sequence Alteration;Fluorescence-Activated Cell Sorting;frontier;Grant;Hematopoietic System;High Pressure Liquid Chromatography;human disease;human subject;Immune;improved;Impulsivity;Infrastructure;instrument;International;ion source;Ions;Kidney Transplantation;KRAS2 gene;Label;laser capture microdissection;Lasers;liver transplantation;Maps;Mass Spectrum Analysis;Measurement;Methods;Molecular Profiling;Monitor;nano;Nature;novel;Oncology;Optics;Patients;Peripheral Blood Mononuclear Cell;portability;Proteins;Proteome;Proteomics;Reaction;Research;Resources;RNA Splicing;Sampling;Science;Signal Transduction;Solid;Solid Neoplasm;Specificity;Specimen;Spottings;Steam;Techniques;Technology;technology development;technology research and development;Tissues;Translational Research;Transplant Recipients;Variant;Work

PROJECT_TITLE: TR&D 7: Cell Specific Proteomics


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Pediatric;Pediatric Cancer;Rare Diseases

PROJECT_TERMS: Acceleration;Aging;alpha synuclein;Amyloid beta-Protein;Apolipoproteins C;Area;Automobile Driving;Biomedical Research;Biopsy;cancer proteomics;Cardiac;cell type;Cells;Child;Clinical;Collaborations;Communities;Complex;Coronary Arteriosclerosis;Dedications;Development;Diffuse intrinsic pontine glioma;Disease;Disease Progression;disorder risk;Disparate;Epidemiology;ESKAPE pathogens;experience;Geography;Goals;Graft Rejection;Grant;Health;High Density Lipoproteins;Human;human disease;improved;informatics tool;innovation;Malignant Childhood Neoplasm;Malignant neoplasm of brain;Malignant Neoplasms;Mass Spectrum Analysis;Medicine;Metals;Methods;Monitor;Multi-Drug Resistance;Nerve Degeneration;neuroproteomics;next generation;novel;organ transplant rejection;particle;pathogen;Post-Translational Protein Processing;professor;Proteomics;Publishing;Reaction;Research;Research Personnel;Resources;Role;Science;Services;Structure;success;tau Proteins;Technology;technology research and development;Therapeutic Intervention;Time;Tissues;TP53 gene;Translating;Transplantation;United States National Institutes of Health;Work

PROJECT_TITLE: Driving Biomedical Projects