ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Genetics;Mental Health;Neurosciences;Opioid Misuse and Addiction;Opioids;Social Determinants of Health;Substance Misuse

ORG_CITY: LAWRENCE

ORG_NAME: UNIVERSITY OF KANSAS LAWRENCE

ORG_STATE: KS

PHR: Project Narrative This proposal uses an early social isolation (ESI) mouse model to investigate pathway-specific (PFC-VTA or PFC-NAc) synaptic transmission and molecular mechanisms involved in ESI-potentiated vulnerability for heroin relapse, measured by cue-induced drug seeking after abstinence from heroin self-administration. These studies may contribute to the development of more efficient pharmacotherapies for relapse prevention.

PI_NAMEs: WANG, ZIJUN  (contact)

PROGRAM_OFFICER_NAME: BERTON, OLIVIER

PROJECT_TERMS: Abstinence;addiction;Adolescence;Adult;Affect;Affinity Chromatography;Amphetamines;Attenuated;Behavior;Behavioral;behavioral study;Bioinformatics;Candidate Disease Gene;career;Chronic;Chronic stress;cocaine seeking;comparative;craving;Cues;Data;designer receptors exclusively activated by designer drugs;Development;differential expression;Drug abuse;Drug Regulations;drug relapse;Drug usage;Early identification;early life adversity;early life stress;Electrophysiology (science);Evaluation;Exposure to;Functional disorder;Gene Expression;Gene Mutation;Gene Transfer;Genes;Genetic;genetic approach;Genetic Transcription;genome-wide;Glutamates;Goals;Heroin;Heroin Dependence;Human;Immunofluorescence Immunologic;insight;Life;Locomotion;Measures;Medial;Mediating;Mental disorders;Mental Health;Methods;Modeling;Molecular;Molecular Profiling;Motivation;mouse model;Mus;nerve supply;neurobiological mechanism;neuron development;neuronal circuitry;Neurons;Opioid abuser;Pathway interactions;Pharmaceutical Preparations;Pharmacotherapy;Play;pre-clinical research;preclinical study;Prefrontal Cortex;Procedures;Public Health;Regulation;Relapse;relapse prevention;Research;Ribosomes;Risk;Role;Self Administration;Social Behavior;Social Controls;Social Interaction;Social isolation;Stress;stressor;Synapses;synaptic function;Synaptic Transmission;Technology;Testing;Therapeutic;tool;Training;transcriptome sequencing;Transgenic Mice;Translating;Viral

PROJECT_TITLE: Neuronal Circuits and Molecular Mechanisms Underlying Early Social Isolation-Potentiated Heroin Seeking

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


ADMINISTERING_IC: CA

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Breast Cancer;Cancer;Clinical Research;Genetics;Immunotherapy;Women's Health Research

ORG_CITY: ROCHESTER

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE/LAY SUMMARY We have discovered a new role for a protein called ATR in promoting aggressive triple negative breast cancer (TNBC) behavior and the ability of TNBC to survive by hiding from the immune system. Our goal in this proposal is two-fold: 1) investigate how ATR promotes aggressive TNBC behavior in response to external forces that are commonly applied to cancer cell walls as tumors progress and 2) examine whether targeting ATR and this new ATR pathway can reverse TNBC aggressive features and promote the immune system’s ability to fight TNBC. As there are over 32,000 cases of TNBC diagnosed in the United States each year and nearly all patients with metastatic progression succumb to the disease, our results could have a profound impact on health and society.

PI_NAMEs: LOU, ZHENKUN ;MUTTER, ROBERT W (contact)

PROGRAM_OFFICER_NAME: WOODHOUSE, ELIZABETH

PROJECT_TERMS: aggressive breast cancer;anti-PD-1;anti-PD1 therapy;ataxia telangiectasia mutated protein;ATR gene;Behavior;beta catenin;Biopsy Specimen;Breast Cancer cell line;breast cancer diagnosis;breast cancer progression;cancer cell;Cell Cycle;Cell Wall;Cells;Cessation of life;Clinical Trials;Complex;Cytoskeleton;Data;Death Rate;Deposition;Deubiquitinating Enzyme;Deubiquitination;Disease;Disease Progression;disorder subtype;Distant Metastasis;DNA Damage;DNA Repair;DNA replication fork;Enrollment;Epithelial Cells;epithelial to mesenchymal transition;Extracellular Matrix;fighting;Genetically Engineered Mouse;Genome Stability;Goals;Health;Immune Evasion;Immune system;Immune System Diseases;Immunologic Surveillance;Immunosuppression;Immunotherapeutic agent;Immunotherapy;in vivo;inhibitor;insight;Institution;Invaded;Malignant Breast Neoplasm;Malignant Neoplasms;mechanical stimulus;Mechanical Stress;Mediating;Mesenchymal;Modeling;Neoplasm Metastasis;novel strategies;Nuclear;Nuclear Translocation;Pathway interactions;Patients;peripheral blood;Phenotype;Play;Process;Prognosis;programs;Progression-Free Survivals;Property;protein expression;Proteins;Regulation;Resistance;response;response biomarker;Role;Sampling;Signal Pathway;Societies;stemness;Stimulus;Testing;Therapeutic;therapy resistant;Tissues;triple-negative invasive breast carcinoma;tumor;Tumor Cell Invasion;Tumor Immunity;tumor progression;Tumor Suppressor Proteins;ubiquitin isopeptidase;United States;Variant;Xenograft procedure

PROJECT_TITLE: ATR: targeting mechanical stress induced EMT and immune suppression in triple negative breast cancer

STUDY_SECTION: MCTB

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics B Study Section[MCTB]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Hematology;Infectious Diseases;Patient Safety;Sepsis

ORG_CITY: HERSHEY

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: PENNSYLVANIA STATE UNIV HERSHEY MED CTR

ORG_STATE: PA

PHR: Project Narrative Sepsis is a global epidemic with a high disease burden, although clinicians caring for septic patients are unable to distinguish between septic patients who will rapidly recover and those who will develop a prolonged disease course marked by significant morbidity and mortality. This is partly due to our incomplete understanding of the complex underlying immune responses in sepsis as well as our inability to translate research findings into information that is useful to clinicians. This research will contribute to the development of novel techniques that will help clinicians to get individualized results about their patients’ immune responses, to guide their decisions about whether immune-adjuvant therapy may be appropriate for each patient.

PI_NAMEs: BONAVIA, ANTHONY S (contact)

PROGRAM_OFFICER_NAME: ZHAO, XIAOLI

PROJECT_TERMS: Academic Medical Centers;Acute;Adjuvant Therapy;Affect;Applications Grants;Award;Biological Assay;burden of illness;cancer therapy;Caring;Cell Separation;Cells;Cessation of life;Chronic;chronic infection;Clinical;clinical care;clinical predictors;Clinical Research;clinical risk;Complex;Critical Illness;cytokine;Data;Development;Disease;Epidemic;Functional disorder;Goals;Grant;Health Care Costs;Human;human model;Iatrogenesis;Immune;Immune response;Immune System Diseases;Immune Tolerance;Immunologic Adjuvants;Immunologics;in vitro Model;Inflammation;Measurement;Medical;metabolomics;Microfluidics;Morbidity - disease rate;mortality;Myeloid Cells;Myeloid-derived suppressor cells;National Institute of General Medical Sciences;novel;Operative Surgical Procedures;participant enrollment;Patients;Peripheral Blood Mononuclear Cell;Phenotype;point of care testing;Pre-Clinical Model;Preclinical Testing;prognostic;prognostic value;prospective;recruit;Research;Research Personnel;Research Priority;response;Scientist;secondary infection;Secondary to;Sepsis;septic patients;Syndrome;Techniques;tertiary care;Testing;theories;Tissues;tool;transcriptomics;Translating;trial enrollment;Whole Blood

PROJECT_TITLE: Integration of Immunologic Phenotyping with Computational Approaches to Predict Clinical Trajectory in Septic Patients

STUDY_SECTION: MRAD

STUDY_SECTION_NAME: Maximizing Investigators' Research Award - D Study Section[MRAD]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

ORG_CITY: BLOOMINGTON

ORG_DEPT: BIOLOGY

ORG_NAME: TRUSTEES OF INDIANA UNIVERSITY

ORG_STATE: IN

PHR: Project Narrative Cancer cells, stem cells, and activated immune cells use a specialized form of sugar metabolism known as aerobic glycolysis to support cell division and tissue growth. I have discovered that fruit flies (Drosophila melanogaster) also use aerobic glycolysis to support rapid growth. My lab is using this model genetic system to understand how growing animal cells regulate aerobic glycolysis.

PI_NAMEs: TENNESSEN, JASON MICHAEL (contact)

PROGRAM_OFFICER_NAME: BARSKI, OLEG

PROJECT_TERMS: aerobic glycolysis;Affect;Anabolism;Animals;Biological Models;Biomass;cancer cell;cancer survival;carbohydrate metabolism;Cell division;cell growth;Cell Proliferation;Cells;Clinical;Development;Dissection;Drosophila genus;Drosophila melanogaster;Enzymes;estrogen-related receptor;fatty acid oxidation;Fatty Acids;fly;Foundations;Genetic;Genetic Models;Genetic study;Genomics;Glucose;Growth;Growth and Development function;Immune;in vivo;Individual;innovation;Larva;Metabolic;Metabolic Pathway;Metabolism;metabolomics;Modeling;Molecular;novel strategies;Nucleotides;oxidation;Pharmacotherapy;Physiology;Production;programs;pyrimidine metabolism;rapid growth;Reaction;Regulation;Repression;response;Role;Signaling Molecule;stem cells;sugar;Supporting Cell;System;T-Cell Activation;Time;tumor;tumor growth;tumor metabolism;Warburg Effect

PROJECT_TITLE: A Drosophila Model for the Regulation of Aerobic Glycolysis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-T(55)R]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Rural Health;Social Determinants of Health;Telehealth

ORG_CITY: SIOUX FALLS

ORG_NAME: SANFORD RESEARCH/USD

ORG_STATE: SD

PHR: PROJECT NARRATIVE The Sanford Community Cancer Program (SCCP) covers rural communities of the upper Midwest and Central Plains representing a large underserved population for cancer treatment, care delivery and clinical trials. The NCI Community Oncology Research Program (NCORP) partnership will help deliver clinical care and offer clinical trials across the rural area served by the SCCP. This will be accomplished through the following aims: maintain and enhance robust accrual to NCI Division of Cancer Prevention (DCP) supported clinical trials through seven components; address disparities in clinical trial accrual in underserved and underrepresented populations to increase participation; cultivate innovative access points to address barriers to clinical trial accrual through outreach and telemedicine; expand current personnel and infrastructure, and contribute to Cancer Care Delivery Research trials.

PI_NAMEs: ALMQUIST, DANIEL ;MILANOVICH, SAMUEL J. (contact)

PROGRAM_OFFICER_NAME: WHITE, VANESSA

PROJECT_TERMS: Address;Area;Awareness;base;cancer care;Cancer Center;Cancer Control;cancer initiation;cancer therapy;care delivery;chemotherapy;Clinic;clinical care;Clinical Oncology;Clinical Research;Clinical Trials;Collaborations;Communities;Community Clinical Oncology Program;Community Health;Community Networks;Consultations;design;Development;Disparity;Division of Cancer Prevention;Elderly;Ensure;Event;Goals;Health;health care disparity;health care service organization;Health Services Accessibility;Hispanic;Hospitals;Human Resources;hutterite;imaging study;Immigrant;Improve Access;improved;Infrastructure;innovation;Integrated Health Care Systems;Leadership;Malignant Neoplasms;Mentorship;Midwestern United States;multidisciplinary;National Clinical Trials Network;Native Americans;Oncology;operation;outreach;outreach program;Patient Participation;patient population;Patient-Focused Outcomes;Patients;Persons;Pilot Projects;Population;Prevention;programs;Research;Research Infrastructure;Research Personnel;rural America;rural area;Rural Community;Rural Population;rural underserved;screening;Services;Site;Telemedicine;Travel;Underrepresented Populations;underserved area;Underserved Population;Work

PROJECT_TITLE: Sanford Community Cancer Program of the North Central Plains (NCORP)


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;HIV/AIDS;Immunization;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: DURHAM

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE The interaction between biological molecules plays a critical role in all life processes. Our ability to influence these interactions determines whether we can control those processes in the treatment of disease. This project aims to characterize and exploit the detailed physics of these interactions for the development of novel therapeutics for the treatment and prevention of disease.

PI_NAMEs: HENDERSON, RORY  (contact)

PROGRAM_OFFICER_NAME: SHAPIRO, STUART Z

PROJECT_TERMS: Affinity;Antibodies;antibody and antigen binding;Antibody Response;Antigens;B-Cell Antigen Receptor;B-Lymphocytes;Binding;Binding Sites;Biological;Cell Lineage;Complex;Cryoelectron Microscopy;Data;design;Development;Disease;disorder prevention;Dissociation;Distant;Ensure;env Gene Products;Equation;Failure;Germ Lines;Goals;HIV-1;Immunization;improved;Kinetics;Knock-out;Life;Maps;Measures;Methods;Molecular;molecular dynamics;Mutagenesis;Mutate;Mutation;neutralizing antibody;novel;novel strategies;novel therapeutics;Outcome;Pathway interactions;Physics;Play;Polysaccharides;Population;preference;Process;Protein Engineering;protein structure;Resolution;response;Role;Series;simulation;Site;Structure;Thermodynamics;Time;tool;Vaccination;Vaccine Design;Vaccines;Vertebral column;X-Ray Crystallography

PROJECT_TITLE: Assessing HIV-1 Broadly Neutralizing Antibody Association Pathways for Vaccine Immunogen Design


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: LOS ANGELES

ORG_DEPT: CHEMISTRY

ORG_NAME: CALIFORNIA STATE UNIVERSITY LOS ANGELES

ORG_STATE: CA

PHR: The proposed Bridge to the Baccalaureate at California State University, Los Angeles (B2B at Cal State LA) research training program will develop talented and motivated URM-, disadvantaged-, and disabled science students at East Los Angeles College and Pasadena City College for success in academics and research as they prepare for transfer to strong BS programs, and subsequently pursue PhD training in biomedical science disciplines. This will make available a broad range of intellectual perspectives to solve the nation’s biomedical research problems. The proposed B2B at Cal State LA Program is relevant to the mission of the NIGMS Division of Training, Workforce Development, and Diversity by contributing significantly to the training and development of a strong and diverse biomedical research workforce.

PI_NAMEs: SWEIMEH, KHULOUD ;TUNSTAD, LINDA M. (contact);VINCENT, JORDAN C.

PROGRAM_OFFICER_NAME: NELSON, SHAKIRA M

PROJECT_TERMS: Achievement;American;Attention;Biomedical Research;bridge to the baccalaureate;California;career;career awareness;Characteristics;Cities;Collaborations;college;Communities;Coupled;Coupling;Creativeness;curriculum enhancement;design;Development;disabled;Disadvantaged;Doctor of Philosophy;doctoral student;Educational workshop;Environment;experience;Growth;improved;Institution;Laboratory Research;Leadership;Los Angeles;Mentors;Minority;Mission;Positioning Attribute;programs;Research;Research Training;Reverse engineering;Science;Scientist;skills;Solid;success;supplemental instruction;support network;Talents;Time;Training;Training Programs;undergraduate research;undergraduate student;Universities;Work;Writing

PROJECT_TITLE: Bridges to the Baccalaureate at Cal State LA

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - D[TWD-D]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Infectious Diseases;Lung

ORG_CITY: NEW YORK

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: PROJECT NARRATIVE Aspergillus fumigatus is an opportunistic pathogenic mold that can cause invasive aspergillosis, a fatal lung infection of immunocompromised patients. Preliminary data indicate that IL-1 signaling is required for murine survival and leukocyte killing of A. fumigatus. This three-year research training plan seeks to uncover the immune and lung structural cells involved in IL-1-dependent crosstalk during A. fumigatus infection to support development of targeted therapeutics promoting sterilizing immunity in patients with invasive aspergillosis.

PI_NAMEs: MILLS, KATHLEEN  (contact)

PROGRAM_OFFICER_NAME: LOVE, DONA

PROJECT_TERMS: Ablation;alveolar epithelium;Alveolar Macrophages;anti-fungal agents;Aspergillosis;Aspergillus;Aspergillus fumigatus;Biology;Bone Marrow;cell killing;cell type;Cells;Cellular Immunology;Chemotactic Factors;Chimera organism;Communication;CSF3 gene;cytokine;Data;design;Development;Environment;Enzyme-Linked Immunosorbent Assay;Epithelial Cells;Flow Cytometry;fungicide;Genetic;Goals;Granulocyte-Macrophage Colony-Stimulating Factor;Host Defense;Human;human pathogen;Immune;immune function;Immune response;Immunity;Immunocompromised Host;Immunofluorescence Microscopy;Infection;Inflammatory;Innate Immune Response;Institution;Interferons;Interleukin-1;Interleukin-1 alpha;Interleukin-1 Receptors;Knockout Mice;Knowledge;Laboratories;Leukocytes;Licensing;Life;Ligands;Lung;Lung Diseases;Lung immune response;Lung infections;lung pathogen;Maps;Measures;Mediating;Medical;Microscopy;Modeling;Molds;Molecular Immunology;monocyte;mortality;mouse model;Mus;Myelogenous;Natural Immunity;neutrophil;novel therapeutics;pathogen;Pathogenesis;pathogenic fungus;Pathogenicity;Patients;Phagocytes;Phagocytosis;pharmacologic;Prevention;Production;programs;Property;Publishing;pulmonary function;radioresistant;receptor expression;Receptor Signaling;recruit;Reporter;Reproduction spores;Research;Research Training;response;Role;Signal Pathway;Signal Transduction;Source;success;targeted treatment;Testing;The science of Mycology;Training;uptake;Vascular Endothelial Cell;Wild Type Mouse;Work

PROJECT_TITLE: IL-1 signaling in defense against Aspergillus fumigatus infection


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: VALHALLA

ORG_DEPT: PHARMACOLOGY

ORG_NAME: NEW YORK MEDICAL COLLEGE

PHR: Project Narrative Hypokalemia or Hyperkalemia have potentially lethal consequence such as cardiac arrhythmia or arrest. We have now identified a novel mechanism by which the kidney regulates K excretion or absorption. The new concept will expend the current knowledge regarding renal K transport and may lead to development of new approach for treatment of hypokalemia and hyperkalemia.

PI_NAMEs: LIN, DAO-HONG  (contact)

PROGRAM_OFFICER_NAME: KETCHUM, CHRISTIAN J

PROJECT_TERMS: absorption;Aldosterone;Arrhythmia;Attenuated;Companions;Complex;Data;Development;Dietary Potassium;Distal;Distal convoluted renal tubule structure;epithelial Na+ channel;Excretory function;FRAP1 gene;genetic regulatory protein;Heart;Heart Arrest;Homeostasis;hyperkalemia;Hypokalemia;IGF1 gene;Insulin-Like Growth Factor I;Intake;KCNJ1 gene;Kidney;Knockout Mice;Knowledge;Life;LoxP-flanked allele;Lysine;Mediating;member;Messenger RNA;mouse model;Nephrons;Neurons;novel;novel therapeutic intervention;Pathway interactions;Phosphorylation;Phosphotransferases;Plasma;Play;Potassium;Potassium Channel;prevent;Regulation;Renal tubule structure;Role;sensor;Sirolimus;Skeletal Muscle;SLC12A3 gene;symporter;Testing;urinary;wasting

PROJECT_TITLE: Regulation of Kir4.1/Kir5.1 and renal potassium excretion

STUDY_SECTION: KUFD

STUDY_SECTION_NAME: Kidney and Urological Systems Function and Dysfunction Study Section[KUFD]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Complementary and Integrative Health;Dissemination and Implementation Research;Drug Abuse (NIDA only);Mental Health;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: Newark

ORG_DEPT: PSYCHIATRY

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: RELEVANCE Implementation of evidence-based behavioral interventions that enhance treatment success among people receiving medication for opioid use disorder (MOUD) is needed. The objective of this study is to identify optimal implementation strategies for Mindfulness-Oriented Recovery Enhancement and Scripted Mindfulness Practice in methadone treatment (MT) and to examine their impact among people with opioid use disorder. This study could provide an evidence base and implementation strategy for mindfulness-based interventions in MT.

PI_NAMEs: COOPERMAN, NINA  (contact);GARLAND, ERIC LEE

PROGRAM_OFFICER_NAME: SU, SHELLEY

PROJECT_TERMS: Abstinence;Acceleration;acceptability and feasibility;addiction;Address;Adherence;Affect;American;Anxiety;arm;Behavior Therapy;Brain;Case Study;Clinic;Clinical Trials;Communities;COVID-19;craving;Data;Disparity;Dissemination and Implementation;Dropout;Drug Prescriptions;Drug usage;Educational Materials;effective intervention;Effectiveness;effectiveness evaluation;effectiveness testing;effectiveness trial;effectiveness/implementation study;emotion dysregulation;emotional distress;evidence base;experience;Feedback;Future;Group Therapy;health care settings;hedonic;Heroin;implementation facilitators;implementation strategy;Internet;Intervention;Manuals;Measures;medication for opioid use disorder;Mental Depression;methadone treatment;Methods;mindfulness;mindfulness intervention;Modeling;novel;Opioid;opioid epidemic;opioid overdose;opioid use;opioid use disorder;Pain;Patient-Focused Outcomes;Patients;Personal Satisfaction;Persons;Population;prescription opioid misuse;prevent;primary outcome;programs;Provider;Quality of life;Randomized;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recovery;Relapse;remediation;remote delivery;Research Design;Resources;reward processing;Rewards;secondary outcome;skills;success;Supervision;System;Technology;therapy design;Time;timeline;Trainers Training;Training;Translations;treatment as usual;United States;Universities;uptake;Videoconferencing

PROJECT_TITLE: Implementation and Effectiveness of Mindfulness Oriented Recovery Enhancement as an Adjunct to Methadone Treatment for Opioid Use Disorder

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Infectious Diseases;Rare Diseases

ORG_CITY: CHICAGO

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative Infections caused by the highly lethal marine pathogen Vibrio. vulnificus are the most burdensome foodborne illness. The proposed study investigates pathogenesis mechanisms of Multifunctional-Autoprocessing Repeats- in-Toxin (MARTX) toxin, a primary bacterial toxin produced by V. vulnificus. By investigating host receptor(s) and receptor binding domains on MARTX, the proposed work will provide important basic science knowledge on toxin functions and inform generation of novel therapeutics to combat lethal infections.

PI_NAMEs: CHEN, JIEXI  (contact)

PROGRAM_OFFICER_NAME: ZEITUNI, AMIR E

PROJECT_TERMS: Address;Animals;Antibiotic Resistance;Antibodies;Bacteria;Bacterial Proteins;Bacterial Toxins;Basic Science;Binding;Biological Assay;Biology;Black Box;C-terminal;Calcium ion;career;Caspase;Cell Death;Cell Line;Cell membrane;Cell Membrane Proteins;Cell surface;Cells;Cellular Assay;Cessation of life;climate change;coastal water;combat;Communicable Diseases;Communication;Consensus Sequence;Consumption;Core Facility;CRISPR screen;Cytolysis;Cytosol;Cytotoxin;Data;Defect;design;Disease;economic cost;enteric infection;Environment;Epithelial Cells;Exhibits;extracellular;Family;Fatality rate;Flow Cytometry;Fluorescence Microscopy;Fluorescence Resonance Energy Transfer;foodborne;foodborne illness;Foundations;Gastroenteritis;Generations;Genes;genetic manipulation;Genetic Screening;genome-wide;Global Warming;Goals;Gram-Negative Bacteria;Grant;gulf coast;Hospitalization;Hour;Human;Immunofluorescence Immunologic;In Vitro;Incidence;Individual;Infection;instrument;intestinal epithelium;Intestines;Intoxication;Journals;Knock-out;Knowledge;Lead;Life;Lysine;marine;medical schools;meetings;Membrane;Membrane Proteins;Microscopic;Mission;Modeling;Monoclonal Antibodies;Multi-Drug Resistance;Mutation;National Institute of Allergy and Infectious Disease;novel therapeutics;open wound;pathogen;Pathogenesis;Pathogenicity;Penetration;Phosphotransferases;Phytic Acid;Play;Predisposition;prevent;Principal Investigator;programs;Property;Protease Domain;Protein Biochemistry;Protein Fragment;Protein Kinase;protein purification;protein structure;Proteins;Public Health;receptor;receptor binding;Research;Research Personnel;Research Support;Resistance;Role;Seafood;Sepsis;Septicemia;Signal Transduction;skills;Surface;System;Targeted Toxins;Techniques;Terminal Repeat Sequences;Testing;TGFBR2 gene;therapeutic development;Toxin;toxin V;Training;training opportunity;Universities;Vibrio;Vibrio vulnificus;Virulence Factors;Water;Work;wound;Wound Infection;Writing

PROJECT_TITLE: Determine host surface interactions of MARTX toxin of foodborne Vibrio vulnificus


ADMINISTERING_IC: AG

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging

ORG_CITY: AMES

ORG_DEPT: GENETICS

ORG_NAME: IOWA STATE UNIVERSITY

ORG_STATE: IA

PHR: Project Narrative Dysregulated mitochondrial function is associated with many age-related diseases. Resolving the contributing mechanisms underlying age-dependent declines of mitochondrial health is a pressing goal of basic and translational aging research. This research aims to delineate novel organelle communication mechanisms involved in maintaining mitochondrial homeostasis during aging. This study will contribute to the discovery of interventions targeting mitochondria for the treatment of age-related diseases.

PI_NAMEs: BAI, HUA  (contact)

PROGRAM_OFFICER_NAME: FU, YI-PING

PROJECT_TERMS: Age;age related;age related changes;age related decline;age-related disease;Aging;Anabolism;Animals;Area;Attenuated;Binding;Binding Proteins;biological adaptation to stress;Biological Assay;Cell Aging;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Communication;Drosophila genus;Enzymes;extend lifespan;Feedback;Functional disorder;fusion gene;genetic manipulation;Genetic Transcription;genome editing;Goals;Health;Hepatocyte;Homeostasis;human old age (65+);Imaging Device;Impairment;insight;interdisciplinary approach;Intervention;lipid metabolism;Lipids;Longevity;Mediating;Metabolic;Metabolism;metabolomics;Mitochondria;Monoubiquitination;Morphology;novel;Organelles;overexpression;oxidation;Oxidation-Reduction;Oxidative Stress;Pathology;Pathway interactions;peroxisome;Phospholipid Ethers;Phosphorylation;Phosphotransferases;Plasmalogens;Play;preservation;Protein Import;Proteins;Proteomics;PXR1 protein;Reactive Oxygen Species;receptor;recruit;Recycling;Regulation;repaired;Research;Role;Site;Stress;Structure;Testing;Tissues;Transcriptional Regulation;ubiquitin ligase;Up-Regulation;Very Long Chain Fatty Acid;Work

PROJECT_TITLE: Role of peroxisome-mitochondrion communication in tissue aging

STUDY_SECTION: CMAD

STUDY_SECTION_NAME: Cellular Mechanisms in Aging and Development Study Section[CMAD]


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Complementary and Integrative Health;Digestive Diseases;Genetics;Inflammatory Bowel Disease;Microbiome;Nutrition

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE  Loss of intestinal barrier function is a hallmark of inflammatory bowel disease (IBD), a condition afflicting 6.8 million people worldwide in 2017 with substantially increasing prevalence, particularly in the USA. Microbiota-derived purines were recently identified to support intestinal barrier function and wound healing during disease and represent a potential therapeutic avenue for IBD treatment. This work will employ a mutant bacterium enriched in purine production to not only delineate the role of microbial-derived purines in intestinal metabolism, barrier function, and wound healing, but also assess the therapeutic efficacy of such a genetically modified organism as a next generation probiotic in disease intervention.

PI_NAMEs: LEE, JOSEPH SCOTT (contact)

PROGRAM_OFFICER_NAME: SASLOWSKY, DAVID E

PROJECT_TERMS: 5'-AMP-activated protein kinase;Advisory Committees;Apical;Apoptosis;Apoptosis Regulation Gene;Award;Bacteria;Biogenesis;C57BL/6 Mouse;Caco-2 Cells;career;Cell Proliferation;Cell secretion;Cells;cohort;Colitis;Collaborations;Colon;Communities;Complex;Critiques;Development;Development Plans;Differentiation Antigens;Disease;dysbiosis;endoplasmic reticulum stress;energy balance;Energy Metabolism;Environment;Epithelial Cells;Epithelium;Escherichia coli;experimental study;Feces;Feedback;Fostering;Foundations;gastrointestinal epithelium;Gastrointestinal tract structure;Genetically Modified Organisms;Germ-Free;Glycolysis;glycosylation;Growth;gut health;Gut Mucosa;Habitats;Harvest;Health;Histologic;Hypoxanthines;Immune system;Immunology;In Vitro;in vivo;Inflammatory Bowel Diseases;inorganic phosphate;Intervention;intestinal barrier;Intestinal Diseases;intestinal epithelium;intestinal homeostasis;Intestines;knock-down;Knock-out;Knockout Mice;Knowledge;Luciferases;Mediating;Mentored Clinical Scientist Development Program;Mentors;Metabolic;Metabolism;microbial;Microbiology;microbiota;microbiota metabolites;microorganism;Molds;Monitor;Mucins;Mucositis;Mucous Membrane;multidisciplinary;Mus;mutant;Mutation;next generation;Nucleotide Biosynthesis;Nucleotides;Nutrient;Oral;Oral Administration;Pathology;Pathway interactions;Pentosephosphate Pathway;Permeability;Persons;Physicians;Prevalence;Probiotics;Process;Production;programs;Proliferating;Proliferation Marker;promoter;Publications;Publishing;purine metabolism;Purines;reconstitution;Recovery;Research;Research Personnel;Resolution;Resources;response;Ribose;Role;Scientist;Severity of illness;Small Interfering RNA;Social Distance;Source;Supplementation;symposium;Testing;Therapeutic;Tissues;TP53 gene;transcription factor;Transfection;Treatment Efficacy;Undifferentiated;wasting;Work;wound healing

PROJECT_TITLE: Microbiota-sourced purines in gut health and disease

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: KNOXVILLE

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF TENNESSEE KNOXVILLE

ORG_STATE: TN

PHR: Project Narrative Genome maintenance is essential to life and disruption of genome integrity often leads to diseases. In this proposal, we will carry out genetics, molecular, and genomic studies in a functional model to study programmed DNA elimination, an exception to the genome constancy rule. These studies will reveal the functions and mechanisms of DNA elimination that will provide insights into genome maintenance and diseases.

PI_NAMEs: WANG, JIANBIN  (contact)

PROGRAM_OFFICER_NAME: MACARTHUR, LINDA

PROJECT_TERMS: 3-Dimensional;Animals;Biochemistry;Bioinformatics;Biological;Biological Process;Biology;Caenorhabditis elegans;Cells;ChIP-seq;chromosomal location;Chromosomes;Clustered Regularly Interspaced Short Palindromic Repeats;comparative genomics;Conserved Sequence;Cytology;Data;Development;Disease;DNA;DNA Transposable Elements;embryo cell;Ensure;Evolution;Excision;Family;flexibility;Gene Expression Profile;Genes;Genetic;genetic manipulation;Genetic Models;Genetic Transcription;Genetic Variation;Genome;genome analysis;genome integrity;genome sequencing;Genome Stability;genome-wide;genomic locus;Genomics;Germ Lines;healing;Histones;In Vitro;insight;Life;Life Cycle Stages;life span;Location;Maintenance;member;Modeling;Molecular;mutant;Mutation;Nematoda;Organism;Phenotype;Phylogenetic Analysis;Plants;Population;Positioning Attribute;Process;Proteins;Repetitive Sequence;Reproducibility;Reproduction;RNA Interference;Role;Site;Small RNA;Somatic Cell;telomere;tool;transcriptome sequencing;Untranslated RNA;Variant;Work

PROJECT_TITLE: A genetic model for metazoan programmed DNA elimination

STUDY_SECTION: GVE

STUDY_SECTION_NAME: Genetic Variation and Evolution Study Section[GVE]


NIH_SPENDING_CATS: Anxiety Disorders;Brain Disorders;Complementary and Integrative Health;Depression;Mental Health;Mental Illness;Natural Products;Neurosciences;Post-Traumatic Stress Disorder (PTSD);Substance Misuse

ORG_CITY: TALLAHASSEE

ORG_NAME: FLORIDA STATE UNIVERSITY

ORG_STATE: FL

PHR: Project Narrative  Alkaloid natural products have had an immense impact on the field of therapeutic medicine, and hold promise for the discovery of new neuropharmacological treatments. The development of new synthetic strategies to build these important molecules allows for the construction of new matter capable of improving upon the available treatments for crippling ailments such as addiction, depression, post-traumatic stress disorder and Parkinson's. Laboratory synthetic access to these important alkaloid natural products holds immense promise for the development of efficacious and novel neuropharmacological small molecules.

PI_NAMEs: SMITH, JOEL MICHAEL (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TITLE: Synthesis of Bioactive Natural Products and Unnatural Congeners


ORG_CITY: NEW HAVEN

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative: While our understanding of the patterns of human genomic variation has greatly improved in the past decades, genetic studies failed to capture the full picture of genetic variation harbored in human populations across the globe. Research in my newly established lab aims to bridge one of the largest gaps in representation in genomics, by leading two large-scale genome sequencing studies of geographically diverse populations in Oceania, with the goal of reconstructing our evolutionary past and disentangling the genetic basis of phenotypic variation and disease susceptibility.

PI_NAMEs: TUCCI, SERENA  (contact)

PROGRAM_OFFICER_NAME: ADKINS, RONALD

PROJECT_TERMS: Address;Admixture;Anthropology;Complex;Computational Biology;Disease susceptibility;DNA;empowerment;Evolution;fitness;Genetic;Genetic Drift;Genetic study;Genetic Variation;Genome;genome sequencing;genome-wide;genomic variation;Genomics;Geography;Goals;Graph;Human;Human Genetics;Human Genome;human pangenome;improved;Inherited;insight;Knowledge;Maps;migration;Modernization;Molecular Biology;Natural Selections;novel;Oceania;Pattern;Phase;Phenotype;Play;Population;population genetic structure;Population Heterogeneity;programs;Recording of previous events;Research;Resolution;Role;Single Nucleotide Polymorphism;Variant

PROJECT_TITLE: Mapping the Full Spectrum of Human Genetic Variation and Archaic Hominin Introgression in Oceania

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-GGG-S(55)]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Genetics;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: BIRMINGHAM

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: We want to study how ADGRB1/BAI1, a cell surface receptor, can exert tumor suppressor functions in brain tumor development. Our goal is to decipher how the extracellular N-terminus of ADGRB1 can suppress mesenchymal transition in glioma, including through prevention of the maturation of growth factor  TGFβ1. The knowledge derived from these studies may lead to the development of novel therapeutics for brain and other cancers.

PI_NAMEs: VAN MEIR, ERWIN G. (contact)

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: adhesion receptor;Adhesions;Affect;Angiogenesis Inhibitors;BAI1 gene;Binding;Binding Proteins;Binding Sites;blood-brain barrier permeabilization;Brain;Brain Neoplasms;cancer cell;Cell Surface Receptors;Cells;chemotherapy;Chemotherapy and/or radiation;Clinical;Complex;conventional therapy;crosslink;Data;Data Set;Deuterium;Development;Diagnosis;Ensure;Epigenetic Process;epigenetic silencing;epigenetic therapy;Excision;experience;extracellular;Extracellular Domain;Family;G-Protein-Coupled Receptors;Gene Expression;Genes;Genetic Transcription;Glioblastoma;Glioma;Goals;Growth Factor;Growth Factor Receptors;Health;Human;Hydrogen;Image;In Vitro;in vitro Assay;in vivo;inhibitor;innovation;Invaded;Knowledge;Laboratories;Lead;Malignant Glioma;Malignant neoplasm of brain;Malignant Neoplasms;Mass Spectrum Analysis;Mediating;Medulloblastoma;Membrane;Mesenchymal;Methylation;Micro Array Data;migration;Molecular;mouse model;mRNA Expression;Mus;N-terminal;Nature;neoplastic cell;novel;novel therapeutic intervention;novel therapeutics;Oncogenic;operation;Operative Surgical Procedures;Orphan;Outcome;overexpression;Pathway interactions;patient prognosis;Patients;Peptides;Phenotype;Pilot Projects;Play;prevent;Prevention;Process;programs;Property;Radiation therapy;Recurrent tumor;Regulation;Research;restoration;Role;Secure;Signal Pathway;Signal Transduction;Slice;targeted treatment;Testing;Therapeutic;therapeutic target;therapy resistant;Thrombospondins;Transforming Growth Factor beta;tumor;Tumor Cell Invasion;tumor growth;tumor progression;Tumor Suppressor Proteins;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Mechanisms underlying BAI1/ADGRB1 negative regulation of glioblastoma mesenchymal transition and invasion.

STUDY_SECTION: TPM

STUDY_SECTION_NAME: Tumor Progression and Metastasis Study Section[TPM]


NIH_SPENDING_CATS: Cancer;Colorectal Cancer;Digestive Diseases;Genetics;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

PHR: PROJECT NARRATIVE The colon is distinct from the small intestine in morphology, cell type composition, function, and disease susceptibility, yet basic understanding of colon biology lags significantly behind that of small intestine, hindering a deeper understanding of colonic diseases and therapeutic development. We identified a chromatin factor that functions as a crucial regulator of colonic stem cell identity and differentiation. We propose in-depth studies of this factor to gain insight on colonic fate regulation and to evaluate a novel therapeutic approach to promote colonic nutrient absorption to treat digestive failure in the Short Bowel Syndrome.

PI_NAMEs: RAFII, SHAHIN  (contact)

PROGRAM_OFFICER_NAME: GREENWEL, PATRICIA

PROJECT_TERMS: absorption;Adult;Appearance;Binding;Biological;Biological Assay;Biology;blood glucose regulation;Cell Lineage;cell type;Cells;ChIP-seq;Chromatin;Chromatin Remodeling Factor;cofactor;Colon;Colonic Diseases;Colorectal Cancer;combat;Compensation;Competence;Data;Development;Disease;Disease susceptibility;Duodenum;Enhancers;Enterocytes;Epithelium;Excision;Failure;Fatty Liver;Functional disorder;Gene Expression;Genes;Genetic;Genetic Transcription;genome-wide;Gland;Goals;Growth;gut inflammation;Histology;Homeostasis;ileum;Immunohistochemistry;insight;Intestinal Diseases;Intestinal permeability;Intestines;jejunum;Large Intestine;LGR5 gene;Malabsorption Syndromes;Mass Spectrum Analysis;Mediating;Modeling;Molecular;Morphology;mosaic;mouse model;Mucous Membrane;Mus;mutant;novel therapeutic intervention;NuRD complex;Nutrient;nutrient absorption;Paneth Cells;permissiveness;Phenotype;Physiological;Physiology;Play;preservation;recruit;Regulation;Role;Short Bowel Syndrome;Small Intestines;stem cells;Structure;Therapeutic;therapeutic development;Tissues;transcription factor;Transcriptional Activation;Transcriptional Regulation;transcriptome sequencing;transcriptomics;Ulcerative Colitis;uptake;Villus;Water;Weight Gain;XCL1 gene

PROJECT_TITLE: Investigating a master regulator of large intestine stem cells

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DNPD-A(01)]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Conditions Affecting the Embryonic and Fetal Periods;Contraception/Reproduction;Heart Disease;Hypertension;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Rare Diseases;Women's Health Research

ORG_DEPT: OBSTETRICS & GYNECOLOGY

PHR: PROJECT NARRATIVE Preeclampsia, a condition characterized by high blood pressure in pregnancy, constitutes a major cause of maternal and perinatal morbidity and mortality; severe hypertension (blood pressure ≥160/110 mmHg) is a common trigger for antihypertensive treatment and preterm delivery. We propose a clinical trial that will test whether lowering the blood pressure of women with preeclampsia at <36 weeks’ gestation to <140/90 mmHg will prolong pregnancy and, therefore, improve maternal and fetal/neonatal outcomes. Data generated in this study, along with knowledge and skills acquired by the candidate in the complementary career development plan, will facilitate an independent research career focused on hypertension and cardiovascular disease in pregnancy and the postpartum period.

PI_NAMEs: SINKEY, RACHEL G (contact)

PROGRAM_OFFICER_NAME: SIDDIQUI, AYESHA SAEED

PROJECT_TERMS: 37 weeks gestation;Acute;Acute Kidney Failure;Admission activity;adverse maternal outcomes;Affect;Alabama;American;American College of Obstetricians and Gynecologists;American Heart Association;Amniotic Fluid;Anti-Hypertensive Agents;Arteries;Award;Biological Markers;Birth;Blood;Blood Pressure;Bronchopulmonary Dysplasia;Cardiology;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;Cardiovascular system;career;career development;Cessation of life;Clinical;Clinical Research;Clinical Trials;college;Conduct Clinical Trials;Conflict (Psychology);Data;design;Development Plans;Diagnosis;Eclampsia;endothelial dysfunction;fetal;Fetal Death;Fetal Growth Retardation;Fetal health;Fetus;Foundations;Funding;Future;Goals;Grant;Guidelines;hazard;Heart failure;hospital readmission;Hypertension;hypertension control;improved;Intensive Care Units;interest;Intervention;intraventricular hemorrhage;Knowledge;Knowledge acquisition;Life;lifetime risk;Liver Dysfunction;Long term disability;Masks;Master of Science;Maternal Health;maternal morbidity;Maternal Mortality;maternal risk;maternal serum;Maternal-fetal medicine;Mentors;Mentorship;Mothers;Multi-Institutional Clinical Trial;Multiple Organ Failure;Necrotizing Enterocolitis;Neonatal;Neonatal Intensive Care Units;Neonatal Mortality;neonatal outcome;neonate;offspring;open label;Organ;Outcome;Participant;participant enrollment;Pathway interactions;Patients;Perfusion;Perinatal;perinatal health;perinatal morbidity;Perinatal mortality demographics;Pharmaceutical Preparations;Phase;Postpartum Period;Pre-Eclampsia;Pregnancy;pregnancy hypertension;Pregnant Women;premature;Premature Birth;Productivity;Professional Competence;Prolonged Pregnancy;Public Health;Pulmonary Edema;Randomized;randomized, clinical trials;Recommendation;Research;research study;Retinopathy of Prematurity;Safety;Scientist;skill acquisition;skills;Small for Gestational Age Infant;Stroke;Testing;Thrombocytopenia;Time;Training;treatment arm;treatment as usual;University resources;usual care arm;Uterus;Woman;women's reproductive health;Writing

PROJECT_TITLE: The ACHIEVE Trial: Achieving longer gestation in preeclampsia via antihypertensive therapy.

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(JA)]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Data Science;Depression;Machine Learning and Artificial Intelligence;Major Depressive Disorder;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Neurosciences;Precision Medicine;Serious Mental Illness

ORG_CITY: ATLANTA

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative Recent mental health studies, both cross-sectional and longitudinal, have led to an expanded depth of neuroimaging, clinical assessments and physiological data, which provide an unprecedented opportunity for crosscutting investigations that may offer new insights to mechanisms and trajectory of mental disorders. However, much-needed statistical methods for exploring discoveries are lacking. In this project, we seek to develop rigorous and computationally efficient statistical methods for neural circuitry analysis, predictive modeling and longitudinal modeling of multi-dimensional data to facilitate diagnosis, deepen mechanistic understanding and improve treatment of mental disorders.

PI_NAMEs: GUO, YING  (contact);KANG, JIAN

PROGRAM_OFFICER_NAME: WOUHIB, ABERA

PROJECT_TERMS: Address;Advanced Development;analytical tool;Award;Behavior;Behavior assessment;behavior change;Biological Markers;Brain;Brain imaging;Clinical;Clinical assessments;clinical biomarkers;cohort;Communities;Complex;Computational Technique;computer framework;Data;Data Analyses;data platform;Data Set;denoising;depressive symptoms;Development;Diagnosis;Diffusion Magnetic Resonance Imaging;dimension reduction;Dimensions;Disease Progression;disorder subtype;effective therapy;endophenotype;feature extraction;Feeling suicidal;Fingerprint;Functional Magnetic Resonance Imaging;Funding;Goals;graphical user interface;High-dimensional Modeling;Human;Hybrids;Image;imaging modality;imaging study;improved;independent component analysis;Individual;individualized medicine;innovation;insight;Investigation;Joints;Lead;learning strategy;Libraries;Link;longitudinal analysis;Longitudinal Studies;magnetic resonance imaging/electroencephalography;Major Depressive Disorder;Measures;Mental Depression;Mental disorders;Mental Health;method development;Methods;Modeling;multidimensional data;multimodal neuroimaging;multimodality;National Institute of Mental Health;neural;neural circuit;neural network;Neural Pathways;neurobiological mechanism;neuroimaging;neuroimaging marker;Neurosciences Research;novel;Patients;Phenotype;Physiological;predict clinical outcome;Prediction of Response to Therapy;predictive modeling;predictive tools;Psychiatry;Pythons;Regimen;Relapse;Research;Sample Size;Selection for Treatments;Statistical Methods;Strategic Planning;Structure;Symptoms;Time;tool;Treatment outcome;treatment planning;treatment response;United States National Institutes of Health;user friendly software;Validation

PROJECT_TITLE: Statistical ICA Methods for Analysis and Integration of Multi-dimensional Data

STUDY_SECTION: BMRD

STUDY_SECTION_NAME: Biostatistical Methods and Research Design Study Section[BMRD]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dementia;Machine Learning and Artificial Intelligence;Mental Health;Neurodegenerative;Neurosciences;Patient Safety;Precision Medicine

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: Project narrative: The study aims to establish an integrated healthcare database and a novel analytical framework for causal analyses comparing continuation vs. different discontinuation strategies of antipsychotic medications (APMs) used to manage delirium due to hospitalization in persons living with dementia (PLWDs). The proposal will produce data reflecting routine-care delivery to optimize delirium pharmacotherapy management in PLWDs and a generalizable framework that facilitates evidence generation guiding deprescribing of potentially inappropriate medications in older adults.

PI_NAMEs: LIN, JOSHUA K (contact)

PROGRAM_OFFICER_NAME: SALIVE, MARCEL

PROJECT_TERMS: Acute;Admission activity;Adopted;advanced dementia;adverse outcome;Adverse reactions;Algorithms;Alzheimer's disease patient;Alzheimer's disease related dementia;Antipsychotic Agents;Arrhythmia;Aspiration Pneumonia;Assessment tool;atypical antipsychotic;care delivery;Cessation of life;Clinical;Clinical assessments;clinical phenotype;comorbidity;comparative;Consent;Data;data mining;Data Set;Databases;Delirium;Dementia;Dose;Dose Rate;Electronic Health Record;Evaluation;evidence base;Family;frailty;Functional disorder;Generations;Goals;Health;health assessment;health care service utilization;Healthcare;Hepatic;Heterogeneity;high dimensionality;Hospitalization;improved;Infection;Influentials;Inpatients;Intervention Studies;Kidney;Knowledge;Length of Stay;Life;Link;Machine Learning;Medicare claim;Medication Management;medication safety;mental state;Methods;Monitor;mortality;multidimensional data;novel;off-label use;older adult;Operative Surgical Procedures;Outcome;Patients;Pattern;Performance;Persons;Pharmaceutical Preparations;Pharmacoepidemiology;Pharmacotherapy;phenotyping algorithm;Polypharmacy;precision medicine;Procedures;Process;Prognostic Factor;Proxy;psychological symptom;Randomized, Controlled Trials;readmission rates;Recovery;recruit;Rehabilitation therapy;Reporting;Risk Factors;routine care;Serious Adverse Event;Severities;Subgroup;Symptoms;Time;tool;treatment effect;validation studies;virtual;Vulnerable Populations;Weight

PROJECT_TITLE: A targeted analytical framework to optimize posthospitalization delirium pharmacotherapy in patients with Alzheimers disease and related dementias

STUDY_SECTION: CIDH

STUDY_SECTION_NAME: Clinical Informatics and Digital Health Study Section[CIDH]


NIH_SPENDING_CATS: Data Science;Genetics;Human Genome

ORG_DEPT: PHYSICS

ORG_NAME: GEORGIA INSTITUTE OF TECHNOLOGY

PHR: Project Narrative High-throughput single cell genomics and transcriptomics technologies have allowed researchers to study our cells with unprecedented resolution and scale. With the knowledge obtained on individual aspects of cells and the development of technologies that can jointly profile multi-modality data, we are entering an era of “putting the pieces together”. In this proposal, we propose concepts and methods to integrate multi-omics data to understand cell temporal dynamics and regulatory mechanisms, and we also propose a new concept of “problem integration”, where related computational formulations can be connected into one unified framework to provide a consistent and more general picture of a certain aspect of cells.

PI_NAMEs: ZHANG, XIUWEI  (contact)

PROGRAM_OFFICER_NAME: WANG, PEGGY

PROJECT_TERMS: Biological;Cell Communication;Cell Physiology;cell type;Cells;Chromatin;Data;data integration;data modalities;Dependence;design;Dimensions;Formulation;Future;Gene Expression;gene regulatory network;Individual;Knowledge;Learning;Location;Methods;Modeling;multimodal data;Multiomic Data;multiple data types;multiple omics;Organism;Output;Population;Research Personnel;Resolution;Signal Transduction;single cell ATAC-seq;single cell genomics;Technology;technology development;Time;transcription factor;transcriptome sequencing;transcriptomics

PROJECT_TITLE: Studying temporal dynamics and regulatory mechanisms of single cells with a unified framework and multi-omics data

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-K(55)R]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Genetics;Human Genome;Prevention

PHR: NARRATIVE The proposed project is relevant to public health as this research will contribute to fundamental knowledge about risk factors for developing tinnitus and the metabolic pathways and genetic influences that underlie its persistence. The long-term goal of this research is to identify treatment targets and preventative strategies to reduce the considerable public health burden due to tinnitus-related disability, lost productivity, and mental health suffering, and thereby improve quality of life. This research exemplifies the NIH mission to reduce illness and disability and will advance the mandate of the NIDCD to improve the lives of those with auditory disorders.

PI_NAMEs: ZELEZNIK, OANA ALINA (contact)

PROGRAM_OFFICER_NAME: WATSON, BRACIE

PROJECT_TERMS: Address;Age;American;Analgesics;biobank;Biological Markers;Caffeine;Canada;Candidate Disease Gene;career;Cholesterol Esters;Cognition;cohort;daily functioning;Data;Data Collection;Databases;Development;disability;Disabling;Disease;drug metabolism;Economic Burden;economic impact;effective therapy;Enrollment;Environmental Exposure;Environmental Risk Factor;Enzymes;epidemiologic data;ethnic minority;Etiology;evidence base;experience;Female;follow-up;Frustration;Future;gene environment interaction;Genetic;Genetic study;genetic variant;Genetic Variation;genome wide association study;genomic data;Genomics;Germ-Line Mutation;Goals;Health Care Costs;Hearing;Hearing problem;high risk;homocitrulline;improved;Individual;innovation;Intake;Intervention;Investigation;Knowledge;Lecithin;life span;Logistic Regressions;Longitudinal cohort;Longitudinal cohort study;Lysophosphatidylcholines;male;member;men;Mental Health;Meta-Analysis;Metabolic Pathway;Metabolism;metabolomics;Mission;modifiable risk;multiple omics;National Institute on Deafness and Other Communication Disorders;neuroprotection;novel;Nurses' Health Study;offspring;Outcome;Participant;Pathway interactions;Phosphatidylethanolamine;Plasma;Plasmalogens;population based;Population Heterogeneity;prevent;Prevention strategy;Productivity;Public Health;Publishing;Quality of life;Questionnaires;racial minority;Research;Research Personnel;Resources;Risk;Risk Factors;secondary analysis;Sleep disturbances;therapeutic target;Tinnitus;treatment strategy;Triglycerides;United States National Institutes of Health;Update;Veterans;Woman;Women's cohort

PROJECT_TITLE: A Multi-omics Investigation of Incident Persistent Tinnitus

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Services;Mental Health;Mental Illness;Post-Traumatic Stress Disorder (PTSD);Primary Health Care

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: NARRATIVE The proposed study aims to conduct a hybrid effectiveness-implementation study, harnessing the strengths of both quantitative and qualitative studies, to examine the effectiveness of a nurse-delivered brief transdiagnostic treatment for anxiety disorders and PTSD in South African primary care clinics. The proposed study will also examine the barriers and facilitators to the implementation of this treatment in primary care clinics in South Africa. The findings from our study have implications for increasing access and the scale-up of evidence-based treatments for anxiety disorders and PTSD in South Africa and other low and middle-income countries.

PI_NAMEs: KORTE, KRISTINA JO (contact)

PROGRAM_OFFICER_NAME: LEVINTOVA, MARYA

PROJECT_TERMS: 3-Dimensional;acceptability and feasibility;Accounting;Address;Anxiety;Anxiety Disorders;Area;Behavior;career;Clinic;Clinical;Clinical Trials;Collaborations;comorbidity;Complex;Control Groups;Data;design;Development;Diagnosis;Diagnostic;diagnostic strategy;disability;Disease;Dissemination and Implementation;dissemination science;Educational Status;effective therapy;effectiveness evaluation;effectiveness trial;effectiveness/implementation design;effectiveness/implementation study;effectiveness/implementation trial;Evidence based treatment;experience;Goals;Health Services Accessibility;HIV;Hybrids;Impairment;implementation barriers;implementation evaluation;implementation facilitators;implementation outcomes;implementation science;implementation strategy;implementation trial;improved;Individual;Intervention;Interview;Literature;low and middle-income countries;Malaria;Measures;Medical;meetings;Mental disorders;Mental Health;Mentorship;Methods;Minority;Modeling;Nurses;Outcome;Patient Participation;patient retention;Patients;Perception;Persons;Phase;Population;Post-Traumatic Stress Disorders;Primary Care;primary care clinic;Primary Nursing Care;primary outcome;Protocols documentation;Provider;Public Health;Publications;Randomized;Research Methodology;Research Personnel;Resources;Safety;Sampling;scale up;Schizophrenia;secondary outcome;Severities;skills;South Africa;South African;standard care;Therapeutic Intervention;therapy design;Time;Training;training opportunity;treatment of anxiety disorders;Work;years of life lost to disability

PROJECT_TITLE: Brief Transdiagnostic Treatment for Anxiety Disorders and PTSD in South Africa: A Hybrid-Effectiveness Trial

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ICP-L(57)R]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics;Networking and Information Technology R&D (NITRD)

ORG_DEPT: MISCELLANEOUS

ORG_NAME: TRUSTEES OF INDIANA UNIVERSITY

PHR: Narrative The proposed research aims to infer gene regulation at the single-cell level. Revealing cell-level gene regulation would not only help to unveil the mystery of the working principle of different living organisms but also provide insights for disease diagnosis, treatment, and prevention.

PI_NAMEs: WANG, YIJIE  (contact)

PROJECT_TERMS: cell type;Cells;computer framework;Computing Methodologies;disease diagnosis;Distal;Foundations;Gene Expression Regulation;insight;machine learning algorithm;Measurement;multiple omics;Organism;Post-Transcriptional Regulation;Prevention;Regulatory Element;Research;Resolution;single cell sequencing;Solid;Techniques;Transcriptional Regulation

PROJECT_TITLE: Revealing cell-level gene regulation through integration of single-cell multi-omics measurements


NIH_SPENDING_CATS: Infectious Diseases;Urologic Diseases

ORG_CITY: CAMBRIDGE

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

PHR: NARRATIVE Transition metals are essential nutrients for all organisms including bacterial pathogens that cause devastating human disease. To prevent infection, the human innate immune system orchestrates a metal-withholding response that attempts to starve invading bacterial pathogens by reducing the availability of essential metal nutrients. Understanding how metal-sequestering proteins such as calprotectin contribute to metal withholding and the host-microbe interaction may inspire new non-traditional antibacterial approaches to prevent and treat microbial infection in humans.

PI_NAMEs: NOLAN, ELIZABETH M (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TERMS: Address;Anti-Bacterial Agents;Area;Bacterial Physiology;Binding;Biochemical;Biological;biophysical properties;Biophysics;Case Study;Cell Physiology;Chemistry;Clinical Research;Complex;design;Development;Diagnostic;Disease;disulfide bond;Disulfides;Environment;Epithelial Cells;expectation;extracellular;Extracellular Space;Funding;Goals;Growth;Homeostasis;Host Defense;host-microbe interactions;Human;human disease;Human Pathology;Immune;in vivo;Infection;Infection prevention;Inflammation;Inflammatory;Innate Immune Response;Innate Immune System;insight;Intestines;Invaded;Investigation;Ions;Laboratories;Leukocyte L1 Antigen Complex;Link;Metals;Methionine;microbial;Modeling;Molecular;molecular modeling;Mus;neutrophil;novel diagnostics;Nutrient;Nutrient availability;Nutritional Immunity;Organism;Outcome;oxidation;pathogen;pathogenic bacteria;pathogenic Escherichia coli;pathogenic fungus;pathogenic microbe;Pathology;Peptide Hydrolases;Physiology;Play;Post-Translational Protein Processing;prevent;Property;Proteins;Research;Resistance;response;Role;Rosaniline Dyes;S100A8 gene;S100A9 gene;Site;Starvation;Structure;Testing;Therapeutic;Transition Elements;uptake;Urinary tract infection;Uropathogenic E. coli;Work

PROJECT_TITLE: Bioinorganic Explorations of Host-defense Proteins

STUDY_SECTION: MSFA

STUDY_SECTION_NAME: Macromolecular Structure and Function A Study Section[MSFA]


ORG_CITY: MANHASSET

ORG_NAME: FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH

PHR: RELEVANCE Immunology is a major field that is increasingly influencing medical care and therapeutics across a wide range of disease specialties. The Institute of Molecular Medicine at the Feinstein Institutes for Medical Research provides mentored research opportunities in translational immunology as a mechanism to encourage physician-scientists and PhD scientists to pursue immunology related research that will enhance the care of patients with immunologic and inflammatory disorders.

PI_NAMEs: DAVIDSON, ANNE  (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Grant;Training;translational immunology

PROJECT_TITLE: T32 Training Grant in Translational Immunology

STUDY_SECTION: AITC

STUDY_SECTION_NAME: Allergy, Immunology, and Transplantation Research Committee[AITC]


ORG_CITY: TEMPE

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

ORG_STATE: AZ

PHR: Project Narrative Intrinsically disordered proteins, which lack of a well-defined folded structure alone, play important roles in a variety of intracellular activities. Characterizing the mechanism how these disordered proteins interact with others is therefore critical for understanding the relevant biological process. The research aims at developing a comprehensive set of computational tools to investigate sequence and conformational properties giving rise to biomolecular assemblies containing disordered proteins.

PI_NAMEs: ZHENG, WENWEI  (contact)

PROGRAM_OFFICER_NAME: GERSHENSON, ANNE

PROJECT_TITLE: Decoding the mechanism of disordered protein interactions

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


ED_INST_TYPE: UNIVERSITY-WIDE

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PI_NAMEs: BAHOU, WADIE F;BARASCH, JONATHAN M.;BARON, MARGARET H;KASKEL, FREDERICK JEFFREY (contact)

PROGRAM_OFFICER_NAME: MARIC-BILKAN, CHRISTINE

PROJECT_TERMS: Academia;Address;Area;Award;Benign;Biological;Biology;Biomedical Engineering;Cancer Education Grant Program;career;career development;Caring;Clinical;Clinical Investigator;Clinical Research;Clinical Trials;Collaborations;college;Communication;Complement Factor H;Development;Development Plans;Developmental Biology;Dimensions;Discipline;Disease;Doctor of Philosophy;Education;Educational Curriculum;Educational process of instructing;Enrollment;Environment;Epidemiology;Evaluation;experience;Faculty;field study;Funding;Genitourinary system;Genomics;Geographic Locations;Goals;Grant;Hematological Disease;Hematology;Hospitals;improved;Individual;innovation;Institution;inter-institutional;interdisciplinary collaboration;Interdisciplinary Study;Journals;K-Series Research Career Programs;Kidney;Kidney Diseases;Knowledge;Learning;Learning Skill;life span;Long Island;Manuscripts;Master of Science;Measures;Medical;Medical center;Medical Education;medical schools;Medicine;meetings;Mentors;Methods;metropolitan;Modeling;multidisciplinary;Nephrology;Neurosciences;New York;New York City;next generation;novel;Peer Review;Performance;Persons;Pilot Projects;Positioning Attribute;Postdoctoral Fellow;pre-doctoral;Program Evaluation;Program Research Project Grants;programs;Publishing;Quality of life;remediation;Renaissance;Request for Applications;Research;Research Design;Research Personnel;Research Training;Scholarship;Science;Scientist;Series;skills;social media;strength training;success;Support System;symposium;System;Technical Expertise;Thinking;Time;TNFSF15 gene;Training;Training Programs;translational scientist;United States National Institutes of Health;Universities;urologic;Urologic Diseases;Urology;verbal;Vocabulary;web site;Woman;Work;Writing

PROJECT_TITLE: New York Consortium for Interdisciplinary Training in Kidney, Urological and Hematological Research (NYC Train KUHR)


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Emergency Care;Heart Disease

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

PHR: Project Narrative In the United States, approximately 350,000 people suffer out-of-hospital cardiac arrest per year; the best chance of survival is when defibrillation occurs within 3 minutes. This proposal seeks estimate bystander AED performance in high-risk geographic areas to determine the treatment effect of a drone AED network. Our research has the potential to significantly improve treatment and survival for OHCA.

PI_NAMEs: STARKS, MONIQUE ANDERSON (contact)

PROGRAM_OFFICER_NAME: REDMOND, NICOLE

PROJECT_TERMS: 911 call;Accounting;Advisory Committees;Affect;Age;American;Arrhythmia;Automated External Defibrillator;base;Brain;Cardiopulmonary Resuscitation;Censuses;Characteristics;Chest;Communities;community-level factor;Data;Data Science;Databases;design;Drops;Education;Effectiveness;Elderly;Electric Countershock;Emergency medical service;emergency service responder;Emergency Situation;Emergency treatment;Ensure;Europe;Evaluation;first responder;Funding;Gender;Geographic Locations;geographic risk;Grant;Heart Arrest;heart function;high risk;Hispanic;Hospitals;Household;improved;Incidence;Income;innovative technologies;Institute of Medicine (U.S.);Intervention;Lead;Location;Long-Term Survivors;Measurable;Medical;Medical emergency;Mentors;Mentorship;Methods;Minority;Modeling;models and simulation;multiple data sources;Neighborhoods;Nervous System Physiology;North Carolina;Organ;out-of-hospital cardiac arrest;Outcome;Patients;Performance;Persons;Phenotype;Positioning Attribute;Pragmatic clinical trial;Race;Refractory;Registries;Research;Resuscitation;Risk;Rural;rural counties;sex;simulation;Supervision;Survival Rate;System;Testing;Time;Training;training opportunity;treatment effect;Treatment Effectiveness;treatment pattern;treatment responders;United States;United States National Institutes of Health;Universities;Use Effectiveness;Ventricular Tachycardia;Work

PROJECT_TITLE: Evaluation of the Requirements and Critical Features of a Drone-Deployed AED Network to Improve Community-Level Survival after OHCA

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(MA)]


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Hematology;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: DUARTE

ORG_NAME: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE

PHR: Project Narrative: Acute myeloid leukemia (AML) patients have a poor five-year survival (<30%), likely due to the persistence of a very resistant leukemic cell population called leukemia stem cells (LSCs). We identified a small RNA molecule called miR-126 as a potential target in LSCs and have invented and produced a miR-126 inhibitor called miRisten to eliminate the otherwise treatment-resistant AML LSCs. We are planning to test this new compound by conducting mechanistic, pharmacokinetic, pharmacodynamic and toxicology studies followed by a phase 1 clinical trial in AML patients with resistant disease.

PI_NAMEs: KUO, YA-HUEI  (contact);MARCUCCI, GUIDO ;NGUYEN, LE XUAN TRUONG

PROGRAM_OFFICER_NAME: OLKHANUD, PUREVDORJ BALJINNYAM

PROJECT_TERMS: Acute Myelocytic Leukemia;Adverse event;Allogenic;Apical;Apoptosis;Attenuated;Automobile Driving;BCL1 Oncogene;Bone Marrow;Cells;Clinic;Clinical Trials;Correlative Study;curative treatments;Data;deprivation;design;Disease Resistance;Dose;Down-Regulation;Drug Kinetics;Dynamin;endogenous stem cells;Endothelial Cells;Endothelium;Energy-Generating Resources;exhaustion;experimental study;first-in-human;Funding;Future;Growth;Hematopoietic;Hematopoietic stem cells;Homeostasis;Human;inhibitor;invention;Investigation;Investigational New Drug Application;leukemia;leukemia treatment;Leukemic Cell;leukemic stem cell;Maximum Tolerated Dose;Membrane Potentials;Metabolic;Metabolism;MicroRNAs;Mitochondria;mitochondrial membrane;mitochondrial metabolism;Molecular;Molecular Mechanisms of Action;Mus;nonhuman primate;novel;novel therapeutic intervention;Output;Oxidative Phosphorylation;Patients;pharmacodynamic model;Pharmacodynamics;pharmacokinetics and pharmacodynamics;pharmacologic;Phase;Phase I Clinical Trials;phase I trial;Population;prevent;Principal Investigator;Production;protein biomarkers;Proteins;Rattus;Reactive Oxygen Species;Recommendation;Refractory;Refractory Disease;Relapse;Resistance;safety assessment;Schedule;self renewing cell;Signal Transduction;Small RNA;Source;stem cell exhaustion;stem cell homeostasis;Stem cell transplant;Testing;Therapeutic;therapeutically effective;Toxicology;Translating;Transplantation

PROJECT_TITLE: Targeting MicroRNAs to Eradicate Leukemia Stem Cells

STUDY_SECTION: DT

STUDY_SECTION_NAME: Developmental Therapeutics Study Section[DT]


PHR: Narrative There is an urgent need to train investigators in the related fields of kidney, urology and hematology. In this U2C/TL1 proposal we bring together expertise in research and education from the Albert Einstein College of Medicine, the Columbia University Irving Medical Center, the Icahn School of Medicine at Mount Sinai and the Renaissance School of Medicine at Stony Brook University, to establish the “New York Consortium for Interdisciplinary Training in Kidney, Urological and Hematological Research”. This consortium will train a new generation of investigators, who will recognize the value of interdisciplinary collaboration in kidney, urology, and hematology research.

PI_NAMEs: BAHOU, WADIE F;BARASCH, JONATHAN M.;BARON, MARGARET H;COCA, STEVEN G;DAVIES, KELVIN P;GREEN, NANCY S.;MALLIPATTU, SANDEEP K;ROSS, MICHAEL J (contact)

PROGRAM_OFFICER_NAME: SADUSKY, ANNA BURKART

PROJECT_TERMS: Adult;Affect;Age;American;Anemia;Animal Model;Area;Award;Benign;Benign Prostatic Hypertrophy;Biomedical Engineering;Blood Coagulation Disorders;career;career development;Caring;Childhood;Chronic Kidney Failure;Clinical Trials;Collaborations;collaboratory;college;Development;Development Plans;Diabetes Mellitus;Discipline;Disease;Doctor of Philosophy;early embryonic stage;Education;educational atmosphere;Endowment;Ensure;Epidemiology;Erectile dysfunction;Erythropoiesis;Erythropoietin;Evidence based practice;experience;Financial Support;Fostering;Foundations;Funding;Generations;Genitourinary system;Genomics;Geriatrics;Goals;Grant;Hematological Disease;Hematology;Home;Hypertension;improved;Infrastructure;innovation;Institution;interdisciplinary approach;interdisciplinary collaboration;Interdisciplinary Study;investigator training;Iron;Journals;Kidney;Kidney Calculi;Kidney Diseases;Kidney Failure;Knowledge;Leadership;Learning;life span;Medical center;medical schools;Medicine;Methodology;metropolitan;Morbidity - disease rate;mortality;neonate;Nephrology;Neurosciences;New York;New York City;next generation;novel;Overactive Bladder;peer;peer networks;Persons;Postdoctoral Fellow;pre-doctoral;Principal Investigator;Privatization;Process;Production;Productivity;programs;Quality of life;Recording of previous events;Recycling;Renaissance;Research;Research Personnel;Scientist;Sickle Cell Anemia;skills;Stem Cell Research;strength training;Structure;Study Section;symposium;System;TNFSF15 gene;Training;Training Programs;United States;Universities;Urinary Incontinence;Urinary system;urologic;Urologic Diseases;Urology;virtual;Work


ORG_CITY: La Jolla

ORG_NAME: SALK INSTITUTE FOR BIOLOGICAL STUDIES

PHR: Project Narrative: Overall The human brain contains roughly equal numbers of neuronal and non-neuronal cells. A major unresolved issue in understanding brain function is how the non-neuronal cells integrate neuronal molecular signals, modulate neural circuit structure and function at multiple temporal and spatial scales, and mediate changes in information processing, perception, and behavior. This project will employ a broad range of experimental and theoretical approaches to identify core principles of the bi-directional communication between neuronal and non-neuronal cells in various brain regions and how disrupting this regular communication transforms perception and action in health and disease.

PI_NAMEs: EROGLU, CAGLA ;NIMMERJAHN, AXEL  (contact);TIAN, LIN ;YU, GUOQIANG

PROGRAM_OFFICER_NAME: DAVID, KAREN KATE

PROJECT_TERMS: Address;Anatomy;Astrocytes;Atlases;Behavior;Behavioral Assay;Biology;Brain;Brain region;brain research;cell type;cellular imaging;Collaborations;Communication;Communities;Complex;Computer Models;computerized tools;Data;Data Analyses;Data Science Core;Disease;Elements;Environment;experience;experimental analysis;Gene Expression;gene therapy;genetic analysis;genetic profiling;Goals;Health;Heterogeneity;Human;in vivo imaging;information processing;innovation;Intervention;learned behavior;Link;Machine Learning;mathematical model;Mediating;Methods;Modeling;Modernization;Molecular;Molecular Analysis;molecular dynamics;Molecular Genetics;molecular imaging;Morphology;multidisciplinary;nervous system development;neural;neural circuit;Neuroglia;Neuromodulator;neuronal circuitry;Neurons;neuroregulation;Neurosciences;neurotransmission;Neurotransmitters;novel;operation;Output;Perception;Play;predictive modeling;programs;Protein Engineering;Research Personnel;Research Project Grants;Rewards;Role;Scientist;Signal Transduction;spatial integration;Statistical Data Interpretation;Structure;Supporting Cell;Synapses;synaptic function;System;Techniques;Testing;Theoretical model;theories;Time;tool;tool development

PROJECT_TITLE: Astrocyte Modulation of Neural Circuit Function and Behavior


NIH_SPENDING_CATS: Hematology;Kidney Disease

PHR: Project Narrative Not Applicable – Administrative Core

PI_NAMEs: MELAMED, MICHAL L (contact)

PROJECT_TERMS: Address;Administrator;Admission activity;Adult;Advertising;Affinity;Animal Model;Area;Award;Biomedical Engineering;Clinical Trials;Collaborations;college;Communication;Development;Development Plans;Discipline;Education;educational atmosphere;Ensure;Epidemiology;Evaluation;Evidence based practice;experience;Feedback;Fostering;Funding;Genomics;Goals;Grant;Hematological Disease;Hematology;improved;Incentives;innovation;Institution;interdisciplinary approach;interdisciplinary collaboration;Interdisciplinary Study;Journals;Kidney;Kidney Diseases;Knowledge;Leadership;Learning;Medical center;medical schools;Medicine;meetings;metropolitan;Mission;National Institute of Diabetes and Digestive and Kidney Diseases;Nephrology;Neurosciences;New York;New York City;outreach;Persons;Pilot Projects;Postdoctoral Fellow;pre-doctoral;Principal Investigator;Process;Program Evaluation;programs;recruit;Renaissance;Research;Research Personnel;Self-Examination;social;Stem Cell Research;strength training;Structure;Study Section;success;symposium;Techniques;TNFSF15 gene;Training;Training and Education;Training Programs;United States;Universities;urologic;Urologic Diseases;Urology;Vision;Work


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Data Science;Neurosciences;Substance Misuse

PI_NAMEs: NIMMERJAHN, AXEL  (contact)

PROJECT_TERMS: Accountability;Advisory Committees;Agreement;Astrocytes;Behavior;behavior test;BRAIN initiative;brain research;Budgets;Cells;Communities;cost effective;Data;Data Analyses;Data Science Core;data sharing;Data Storage and Retrieval;Decision Making;Ensure;experimental study;Future;Generations;Genotype;Goals;Human Resources;Leadership;meetings;member;Monitor;Mouse Strains;neural circuit;novel;organizational structure;Participant;Performance;Play;Principal Investigator;Procedures;programs;Reagent;Regulation;Reporting;Research;Research Project Grants;Resources;Schedule;tissue processing;transcriptome sequencing;Transgenic Animals;United States National Institutes of Health

PROJECT_TITLE: Administrative Core


PHR: Project Narrative Not Applicable – Professional Development Core

PI_NAMEs: ROSS, MICHAEL J (contact)

PROJECT_TERMS: Address;Adult;Animal Model;Area;Award;Biomedical Engineering;Brothers;Career Mobility;Clinical Trials;Collaborations;college;Communication;Communities;Competence;design;Development;Development Plans;Developmental Biology;Discipline;Disease;diversity and inclusion;Education;educational atmosphere;Educational Curriculum;Educational workshop;Ensure;Environment;Epidemiology;Equity;Evaluation;Evidence based practice;experience;Exposure to;Fostering;Funding;Future;Genomics;Goals;Grant;Hematology;improved;innovation;Institution;interdisciplinary approach;interdisciplinary collaboration;Interdisciplinary Study;Journals;Kidney;Knowledge;Leadership;Learning;life span;Manuscripts;Medical center;medical schools;Medicine;member;Mentors;Mentorship;metropolitan;Nephrology;Neurosciences;New York;New York City;novel;oral communication;peer;peer support;Pilot Projects;Postdoctoral Fellow;pre-doctoral;Principal Investigator;Program Development;programs;remediation;Renaissance;Research;Research Personnel;Resources;Rewards;Schedule;Science;Sister;skills;skills training;Stem Cell Research;strength training;Stress;Study Section;symposium;synergism;System;TNFSF15 gene;Trainers Training;Training;Training Programs;Universities;urologic;Urology;Work;Writing


ORG_CITY: ROCHESTER

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: PROJECT NARRATIVE The availability of general synthetic methods that build the carbon framework of organic molecules determines the types of compounds that are available for biological studies and therapeutics for the treatment of human diseases. My research program invents new chemical methods that allow for rapid access to novel small molecules with direct relevance to human health. To accomplish this, we develop new technologies in transition metal catalysis that enable new reactivity and selectivity for C–C and C–X bond forming transformations that prepare functional, highly three-dimensional small molecules.

PI_NAMEs: PARADINE, SHAUNA M (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TITLE: Discovering catalytic strategies for transition metal-catalyzed reactions to construct topologically complex organic scaffolds


ADMINISTERING_IC: NR

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Aging;Biotechnology;Breast Cancer;Cancer;Cancer Genomics;Chronic Pain;Clinical Research;Estrogen;Genetics;Human Genome;Neurosciences;Pain Research;Prevention;Women's Health Research

ORG_CITY: CLEVELAND

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE Chronic musculoskeletal pain (MSKP) is a significant problem in many women with hormone receptor-positive early stage breast cancer receiving treatment designed to prevent cancer recurrence by blocking estrogen production via systemic inhibition of the aromatase enzyme. Unfortunately, very little is known about the mechanisms that underly the development of MSKP, which in turn limits the development of effective treatments and prevention strategies. This project will examine both the RNA transcriptome and the DNA methylome to identify genes and biological pathways that are involved in the development of MSKP within the context of declining estrogen levels providing evidence to inform mechanistically driven therapeutic interventions to mitigate the negative consequences of cancer and its treatment.

PI_NAMEs: WAGNER, MONICA ANN (contact)

PROGRAM_OFFICER_NAME: BLACHMAN, DARA

PROJECT_TERMS: Address;Adherence;Adrenergic Agents;alpha 2 agonist;antagonist;Architecture;Aromatase Inhibition;Aromatase Inhibitors;Bioinformatics;Biological;Blood specimen;Brain;Breast;Breast Cancer Prevention Trial;Brief Pain Inventory;Cancer Center;cancer pain;cancer recurrence;cancer therapy;cancer type;career development;chronic musculoskeletal pain;chronic pain;Clinical;Colon;Competence;Data;Development;DNA;DNA Methylation;effective therapy;Ensure;Environment;Enzyme Inhibition;epigenomics;Estrogen decline;Estrogens;evidence base;experience;Faculty;functional status;Gene Expression;Gene Expression Regulation;Genes;gray matter;health care service utilization;hormone receptor-positive;Individual;inhibitor therapy;innovation;interest;Investigation;Knowledge;Lung;Malignant Breast Neoplasm;Malignant Neoplasms;Measures;Mediating;Medical center;Mentors;methylome;Modality;Molecular;Musculoskeletal Development;Musculoskeletal Pain;NCI-Designated Cancer Center;neuroimaging;Newly Diagnosed;novel;Pain;Pain Disorder;pain inhibition;Pain interference;Pathway interactions;Phase;Phenotype;Positioning Attribute;Postmenopause;prevent;Prevention strategy;Production;programs;Prostate;recruit;Research;Resources;response;Risk;RNA;Role;Sampling;Severities;sex;Site;skills;Symptoms;Testing;Therapeutic Intervention;therapy design;Time;Training;transcriptome;transcriptomics;treatment strategy;Universities;white matter;whole genome;Woman

PROJECT_TITLE: Omics of Pain in the Context of Declining Estrogen

STUDY_SECTION: NRRC

STUDY_SECTION_NAME: Nursing Science Review Committee[NRRC(76)]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Bioengineering;Data Science;Genetics;Networking and Information Technology R&D (NITRD);Neurosciences;Substance Misuse

PI_NAMEs: YU, GUOQIANG  (contact)

PROJECT_TERMS: 3-Dimensional;Anatomy;animal data;Architecture;Area;Astrocytes;Atlases;Automobile Driving;Behavior;Brain;ChIP-seq;Communities;computerized tools;Consumption;Coupled;Data;Data Analyses;data analysis pipeline;data dissemination;Data Files;data format;data repository;Data Science Core;Data Set;data sharing;data sharing networks;data visualization;design;digital;digital object identifier;Electron Microscopy;Ensure;Gene Expression;Genes;Genetic Transcription;Goals;Image;Imaging Device;Individual;Infrastructure;Internet;Light;light microscopy;Maps;Measurement;member;Metadata;Methods;Microscopy;Modeling;multiple data types;neural circuit;neuronal circuitry;Online Systems;open source;operation;Pattern;Positioning Attribute;Proteomics;Protocols documentation;Research Personnel;Research Project Grants;Services;Specific qualifier value;Structure;System;Techniques;tool;transcription factor;transcriptome sequencing;ultra high resolution;user-friendly;Visualization;Visualization software;web based interface;web based software;web portal;web-based tool

PROJECT_TITLE: Data Science Core


PHR: Project Narrative Not Applicable – Network Core

PI_NAMEs: DAVIES, KELVIN P (contact)


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: PUBLIC HEALTH NARRATIVE With the population of U.S. adults ages 65 and older growing at a rate 3 times that of those under 65, primary care providers must be prepared to care for the 80% of older adults who have complex care needs due to multiple chronic conditions (MCC). Our Northwestern Older Americans Independence Center will infuse geriatrics principles into primary care and align services with patients' priorities, enhance treatment decision making and promote self-management to optimize function, independence and quality of life among older adults with MCC.

PI_NAMEs: LINDER, JEFFREY A.;WOLF, MICHAEL S (contact)

PROGRAM_OFFICER_NAME: SERRA, MONICA CHRISTINE

PROJECT_TERMS: Acceleration;Address;Adult;Age;Aging;American;Applied Research;Area;Assessment tool;burden of illness;Capsicum;career;career networking;Caregivers;Caring;Chicago;Chronic Disease;Clinical;clinical decision-making;Collaborations;Collection;Communities;Complex;cost effective;Data Analytics;data harmonization;Decision Making;Dedications;design;Development;Discipline;Disease Outcome;education research;Evidence based practice;Faculty;frailty;functional independence;Future;Geriatrics;Government;Growth;Health;Health system;Healthcare;Healthcare Systems;human old age (65+);Illinois;improved;industry partner;Information Dissemination;Infrastructure;innovation;Institution;interest;International;Intervention;Investigation;Learning;Link;Managed Care;Measurement;Medical;medical schools;Mental Health;Mentors;Mentorship;Methodology;Mission;Modeling;multidisciplinary;multiple chronic conditions;novel;older adult;older patient;Outcome;Patient Outcomes Assessments;Patients;physical conditioning;Pilot Projects;Population;Prevalence;Primary Care;primary care practice;primary care provider;programs;provider adherence;Public Health;Quality of life;Research;Research Activity;research faculty;Research Infrastructure;Research Personnel;Resources;Risk;risk stratification;Schools;Scientist;Self Management;Services;social;Technology;technology intervention;Testing;Training;Training Activity;Translating;Universities

PROJECT_TITLE: The Claude D. Pepper Older Americans Independence Center (OAIC) at Northwestern University


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Neurosciences;Substance Misuse

PROJECT_TERMS: Affect;Algorithm Design;Anatomy;Astrocytes;Automobile Driving;Behavior;Behavioral;Binding Sites;Biological Models;Brain;Calcium;Calcium ion;Cells;Chemicals;Color;Communities;Complex;Computer Models;Computer Simulation;Computer Vision Systems;computerized tools;Cyclic AMP;Data;Data Analyses;Databases;Detection;Disease;disease model;Drosophila genus;Elements;Event;experience;experimental study;extracellular;Functional disorder;Gene Expression Profile;Genes;genetic manipulation;Genomics;Goals;Image;improved;information processing;Information Theory;Ions;Knowledge;Label;Learning;Link;mathematical model;Mathematical Model Simulation;Measurement;Measures;Mechanics;Methods;Microscopic;model development;Modeling;Molecular;Molecular Analysis;Morphology;multiplexed imaging;neural circuit;neural model;Neuromodulator;Neurons;Neuropeptides;neuroregulation;Neurosciences;neurotransmission;Neurotransmitter Receptor;Neurotransmitters;Nociception;Output;Pattern;Population;postsynaptic neurons;presynaptic neurons;Property;Resolution;Role;Sensory;sensory input;Signal Transduction;Source;spatial integration;spatiotemporal;Speed;Statistical Data Interpretation;Statistical Models;Structure;System;Time;tool;transcription factor;Translating;Visualization;Work

PROJECT_TITLE: Integrating Astrocytes into Models of Neural Circuits Regulating Behavior


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Prevention;Racial and Ethnic Minority Health Research

ORG_CITY: MADISON

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE Experiencing racial discrimination is harmful to the health and wellbeing of children of color. By creating and testing an intervention to improve how young children treat their peers, the project seeks to improve the social experiences, health, and wellbeing of children of color.

PI_NAMEs: DEVINE, PATRICIA G;SHUTTS, KRISTIN B (contact)

PROGRAM_OFFICER_NAME: ESPOSITO, LAYLA E

PROJECT_TERMS: 7 year old;Address;Affect;Age;Attitude;Awareness;base;Behavior;Belief;Black Populations;Black race;Buffers;Child;Child Welfare;Childhood;children of color;Color;Development;Discrimination;Educational process of instructing;effectiveness study;Environment;Evaluation;Event;evidence base;Exhibits;experience;Goals;Health;Home;improved;innovation;Intervention;intervention effect;intervention program;Laboratories;Learning;Measures;Monitor;Motivation;Nature;novel;Outcome;Parent-Child Relations;parenting intervention;Parents;Participant;peer;Persons;Play;Prevalence;programs;Race;racial bias;racial discrimination;racial diversity;Racial Equity;Racial injustice;Randomized;randomized controlled design;Reaction;recruit;Reporting;Research;Research Personnel;Review Literature;Role;Self Efficacy;Shoulder;social;social situation;Testing;theories;Time;tool;Training;Training Programs;Work

PROJECT_TITLE: Reducing Children’s Racial Biases via a Parent-Led Intervention

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


NIH_SPENDING_CATS: Aging;Clinical Research;Health Services;Primary Health Care

PI_NAMEs: BRADLEY, SARA  (contact)

PROJECT_TERMS: Address;Aging;American;Award;Capsicum;career development;Caring;Charge;Chicago;Chronic Disease;Clinical;Clinical Sciences;Communities;Complex;cost effective;Data;Data Analyses;Dedications;design;Discipline;Disease Outcome;Education;education research;Educational Activities;educational atmosphere;Educational Needs Assessments;Elderly;Ensure;Environment;experience;Exposure to;Faculty;faculty mentor;faculty research;Funding;Future;Geriatrics;Goals;Government;Grant;Growth;Health;health care settings;Health Promotion;Health Status;Healthcare;Healthcare Systems;Illinois;improved;Industry;industry partner;Information Dissemination;Infrastructure;innovation;interest;K-Series Research Career Programs;Knowledge;Leadership;Link;Managed Care;Measurement;Medical;mentoring community;Mentors;Methodology;Midwestern United States;Monitor;multiple chronic conditions;next generation;novel;older adult;older patient;Outcome;outreach;Participant;Patient Outcomes Assessments;patient population;Pilot Projects;Primary Care;primary care practice;Process;programs;Quality of life;Research;research faculty;Research Project Grants;Research Training;Resources;Scholars Program;Schools;Services;skills;social;success;Technology;Time;tool;Training;Training Activity;Translational Research;Translations;Universities;voucher

PROJECT_TITLE: Research Education Component


PI_NAMEs: WOLF, MICHAEL S (contact)

PROJECT_TERMS: Academia;Address;Aging;aging related;American;Applied Research;Basic Science;Behavior Therapy;Biometry;Capsicum;Clinical Sciences;Collaborations;Communication;Communities;community partners;Complex;Consult;design;Development;Education;education research;Evaluation;experience;Faculty;Feedback;functional improvement;Geriatrics;Goals;Government;Health;Health Services Research;Healthcare Systems;Human Resources;improved;Industry;industry partner;Information Dissemination;Infrastructure;innovation;Institution;Interest Group;Internal Medicine;Leadership;Link;Managed Care;Measurable;Measurement;Medical;Medicine;meetings;Methods;Midwestern United States;Mission;Modeling;Monitor;multiple chronic conditions;National Institute on Aging;novel;older adult;operation;Outcome;Persons;Pilot Projects;Primary Care;Process;programs;prospective;Public Health;Qualitative Research;Quality of life;recruit;Reporting;Research;Resource Sharing;Resources;Science;Services;technology intervention;tool;Translational Research;Translations;Universities;Work

PROJECT_TITLE: Leadership & Administrative Core


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Project Narrative We will build and test a novel PET (positron emission tomography) scanner to be used simultaneously with an MRI. This is based on a recent invention of ours to build the PET scanner using a crystal scintillator tube instead of multiple flat panel detectors. The scanner will be built collaboratively between UVa, i3M, and Bruker.

PI_NAMEs: BERR, STUART S. (contact);GONZALEZ MARTINEZ, ANTONIO

PROGRAM_OFFICER_NAME: TORNAI, MARTIN PAUL

PROJECT_TERMS: absorption;anatomic imaging;Animals;Applications Grants;attenuation;Biological Markers;clinical imaging;Computer software;Coupled;Data;design;detector;Diameter;Electrons;Elements;fabrication;Generations;Grant;Human;Image;imaging modality;improved;Industrialization;industry partner;instrumentation;interest;invention;Lead;Legal patent;Length;Light;lung imaging;magnetic field;Magnetic Resonance Imaging;Maps;Measures;Modality;Molecular;molecular imaging;Motion;mouse model;MRI Scans;multimodality;Mus;National Research Council;Neoplasm Metastasis;novel;Optics;Pattern;Performance;photomultiplier;photon-counting detector;Photons;Physiologic pulse;Positioning Attribute;Positron;Positron-Emission Tomography;pre-clinical;preclinical imaging;Radiation;Resolution;response;Rodent;Role;sensor;Series;Shapes;Signal Transduction;Silicon;single photon emission computed tomography;soft tissue;Spanish;Specificity;Surface;Technology;Temperature;Testing;Tissues;Tube;tumor progression;Universities;Virginia;Visualization;water diffusion;Work

PROJECT_TITLE: Fabrication and Testing of a Novel PET insert for Simultaneous PET/MRI


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences;Substance Misuse

PROJECT_TERMS: Adult;Affect;Anatomy;Animal Behavior;Animals;Astrocytes;Atlases;Behavior;Behavioral;Behavioral Assay;Blood Vessels;Brain;Brain region;Cell Communication;Cells;cellular imaging;Chemicals;cholinergic;Communication;Computer Analysis;Computer Models;Coupled;Coupling;Data;Data Science Core;Data Set;Development;Elements;Environment;experimental study;extracellular;Fiber;Gap Junctions;Genetic;Giant Cells;Goals;Heterogeneity;in vivo;in vivo imaging;Individual;Intervention;Ions;Link;Maps;Measurement;Microscopy;Modeling;Molecular;molecular dynamics;multiplexed imaging;Mus;neural;neural circuit;neural patterning;Neuroglia;Neuromodulator;neuronal excitability;Neurons;Neuropeptides;neuroregulation;Neurosciences;Neurotransmitter Receptor;noradrenergic;novel;Pattern;Physiological;Positioning Attribute;predictive modeling;Process;Property;receptor;Regulation;Rewards;Role;Signal Transduction;spatiotemporal;Synapses;Synaptic plasticity;Task Performances;Techniques;Testing;Time;tool

PROJECT_TITLE: Linking Fast Timescale Neuron-Astrocyte Communication to Neural Circuit Function and Behavior


NIH_SPENDING_CATS: Aging;Brain Disorders;Clinical Research;Depression;Emergency Care;Health Services;Machine Learning and Artificial Intelligence;Mental Health;Primary Health Care

PI_NAMEs: MCDERMOTT, MARY MCGRAE (contact)

PROJECT_TERMS: Accident and Emergency department;Advisory Committees;Aging;American;Applications Grants;Applied Research;Award;Back;Capsicum;career;Caregivers;Caring;Chicago;Clinical;Clinical Sciences;Communication;Communities;community involvement;Complex;Data;Depressed mood;design;Development;Direct Costs;education research;Electronics;Emergency Care;Emergency Medicine;expectation;experience;Faculty;faculty support;Foundations;functional improvement;functional outcomes;Funding;Future;Geriatrics;Goals;Grant;Health;hospital readmission;improved;Industry;Information Dissemination;innovation;Institution;intelligent personal assistant;interest;Intervention;Lead;Leadership;Life Cycle Stages;Link;Managed Care;Manuscripts;Measurement;Medical;Medication Errors;meetings;member;Mental Depression;Mentors;Methodology;Modeling;Monitor;multidisciplinary;multiple chronic conditions;novel;older adult;Patients;Peer Review;Pharmaceutical Preparations;Pharmacotherapy;Pilot Projects;pilot test;Primary Care;primary care practice;primary care services;Process;professor;programs;psychologic;Publishing;Quality of life;Readiness;Recommendation;Request for Applications;Research;Research Design;Research Personnel;Research Project Grants;Resources;Services;Skilled Nursing Facilities;Stream;Study Section;System;tool;Training;Translational Research;United States National Institutes of Health;Universities;Voice;Work

PROJECT_TITLE: Pilot/Exploratory Studies Core (PESC)


NIH_SPENDING_CATS: Aging;Clinical Research;Disability Research;Hematology;Infectious Diseases;Microbiome;Precision Medicine;Prevention;Rehabilitation;Sepsis

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

PHR: NARRATIVE Severe infection (sepsis) leads to high mortality and long-term impairments such as physical disability, which diminishes quality of life and overburdens health-care systems. Clinical trials have been ineffective to prevent disability after sepsis, likely because of the lack of understanding of the pathology and variability of sepsis- induced physical disability. To improve future treatments that prevent physical disability, we first must not only better characterize the effect of age, sex, and race/ethnicity on variability in disability outcomes, but also explore the role of the gut microbiome, which uniquely controls the host immune response, depends on biological variability, and affects skeletal muscle in sepsis.

PI_NAMEs: MANKOWSKI, ROBERT T (contact)

PROGRAM_OFFICER_NAME: ZHAO, XIAOLI

PROJECT_TERMS: Acute;Affect;Age;age effect;Animals;Atrophic;Biological;Biological Markers;Catabolism;Chronic;Chronically Ill;Clinical;Clinical Trials;Critical Illness;Development;Disability outcome;Disability prevention;dysbiosis;Ethnic Origin;exercise training;functional decline;Functional disorder;Future;Goals;gut microbiome;Healthcare Systems;Heterogeneity;Hospitalization;human old age (65+);Immune response;immunological status;Immunologics;Immunosuppression;Impairment;improved;Individual;Infection;Inflammation;Intervention;Laboratory Research;Life;mode of exercise;Modeling;mortality;muscle strength;Muscle Weakness;Muscular Atrophy;Nutritional;older adult;Organ;Outcome;Pathology;patient population;Patients;Peripheral;personalized approach;Physical Function;physically handicapped;Population;pre-clinical;precision medicine;prevent;Principal Investigator;profiles in patients;programs;Quality of life;Race;Recovery;Risk;Role;Sepsis;septic patients;sex;Skeletal Muscle;Survivors;Syndrome

PROJECT_TITLE: Understanding pathology of sepsis-induced physical disability for future precision medicine

STUDY_SECTION: MRAD

STUDY_SECTION_NAME: Maximizing Investigators' Research Award - D Study Section[MRAD]