NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research;Rural Health

PI_NAMEs: BEARER, ELAINE L (contact)

PROJECT_TERMS: Age;Alzheimer's Disease;Alzheimer's disease related dementia;American Indians;Autopsy;Biocompatible Materials;Biological Markers;Biological Specimen Banks;Blood Vessels;blood-brain barrier disruption;Board Certification;Brain;brain tissue;Cerebrovascular Disorders;Certification;Chemistry;Clinical;clinical diagnosis;Clinical Pathology;cognitive testing;Collaborations;Collection;Communities;community engagement;Consent;cultural values;Data;Databases;Dementia;Development;Diagnosis;Diagnostic;digital;Disease;DNA;Doctor of Philosophy;education research;Educational process of instructing;Equipment and supply inventories;Ethnic Population;Funding;Goals;Hispanic;Histocytochemistry;Histopathology;Human;human tissue;Image;Immunohistochemistry;Impaired cognition;improved;Inflammatory;innovation;interactive teaching;Intervention;Label;Latinx;Learning;Link;Low income;Magnetic Resonance Imaging;Measurement;Medical;member;Methods;Mexican;Minority Groups;Neurodegenerative Disorders;neuroinflammation;neuropathology;New Mexico;novel;Older Population;outreach;Paraffin;Participant;Pathologic;Pathologist;Pathology;Patients;Persons;Population;Population Heterogeneity;Positioning Attribute;professor;Prosencephalon;Prospective Studies;Proteins;Protocols documentation;Pueblo Race;Recommendation;Research;Research Personnel;Reservations;Resolution;Role;Rural;Rural Community;Sampling;Scientist;Slice;Slide;Specimen;Stains;Teaching Materials;Techniques;Tissues;transcriptomics;Translating;Underrepresented Populations;United States National Institutes of Health;Vascular Diseases;web site;webinar;white matter;White Matter Disease;Work

PROJECT_TITLE: Neuropathology Core


ADMINISTERING_IC: AG

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);American Indian or Alaska Native;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research;Rural Health

ORG_CITY: ALBUQUERQUE

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR

ORG_STATE: NM

PI_NAMEs: RICHARDSON, JESSICA D (contact)

PROJECT_TERMS: Address;aged;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;American Indian community;American Indian Population;American Indian Tribe;American Indians;Ancillary Study;Belief;Biological Markers;Blood Vessels;care outcomes;Caregivers;Caring;Cerebrovascular Disorders;Clinical;Cognitive;cognitive disability;cohort;Collaborations;Communication;Communities;community engagement;Community Health;Community Healthcare;cultural competence;Data;data management;Dementia;design;Detection;digital;Disease;Disparity;education research;effectiveness evaluation;Elderly;Enrollment;Ethics;Event;Friends;Funding;Grant;hearing screening;Hispanic;Home;Individual;Inflammatory;Infrastructure;Knowledge;Latino;Linguistics;Medical;medically underserved population;member;Mentors;Mexican;Neighborhoods;New Mexico;outreach;Participant;Persons;Positioning Attribute;Prevention;primary care provider;Printing;programs;Protocols documentation;Readiness;recruit;Registries;Relationship-Building;Research;Research Personnel;Resource Sharing;Resources;rural area;Rural Population;rural residence;rural underrepresented;Science;Scientific Advances and Accomplishments;Site;social;Specialist;success;System;Translating;tribal community;Tribes;Trust;Underrepresented Populations;Videoconferencing;virtual;Work

PROJECT_TITLE: Outreach, Recruitment and Engagement Core

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-G (J1)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

PI_NAMEs: BHASKAR, KIRAN  (contact)

PROJECT_TERMS: Address;Albumins;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;American Indian Population;American Indians;Autopsy;biobank;Biological;Biological Assay;Biological Markers;Blood;Blood specimen;Blood Vessels;blood-brain barrier permeabilization;Cancer Center Planning Grant;Caring;Caucasians;Cerebrospinal Fluid;Classification;Clinical;Clinical Trials;Cognitive;cohort;Communities;contrast enhanced;cost;cytokine;Data;Databases;Dementia;dementia risk;Development;Diagnosis;Diagnostic;Early identification;early onset;early screening;Education;Etiology;FDA approved;Freezing;Future;Glial Fibrillary Acidic Protein;Goals;Growth Factor;Hispanic;Hispanic Populations;Image;Impaired cognition;improved;Incidence;indexing;Individual;Inflammation;Inflammatory;Infrastructure;Injury;instrument;Latino;Latino Population;Life;Light;Liquid substance;Magnetic Resonance Imaging;Measures;Medical;Methods;Minority Groups;mixed dementia;Nerve Degeneration;neurofilament;neuroinflammation;Neuropsychological Tests;neurovascular;New Mexico;next generation;outreach;Participant;Patients;Peptide Hydrolases;Phase;Plasma;Population;Population Heterogeneity;Positron-Emission Tomography;Prevalence;Prevention;Prognosis;Proteins;recruit;Research;Research Personnel;Resource Sharing;Resources;Risk;Risk Factors;Role;Rural;rural area;Rural Population;rural underrepresented;sample collection;Sampling;screening;Spinal Puncture;tau-1;Test Result;Threonine;Training;treatment trial;Underrepresented Minority;Urban Community;vascular cognitive impairment and dementia;Vascular Diseases;vascular inflammation;white matter;white matter damage;white matter injury;Work

PROJECT_TITLE: Fluid Biomarker Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);American Indian or Alaska Native;Bioengineering;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

PI_NAMEs: CAPRIHAN, ARVIND  (contact)

PROJECT_TERMS: Alzheimer's Disease;Alzheimer's disease related dementia;American Indians;Amyloid;Autopsy;Biological Markers;Blood - brain barrier anatomy;Blood Vessels;blood-brain barrier permeabilization;Brain imaging;brain magnetic resonance imaging;Cerebrovascular Disorders;cerebrovascular reactivity;Clinical;Collaborations;Communities;community engagement;Data;Data Analyses;data management;data quality;Dementia;dementia care;Development;Diagnosis;Disease Progression;Early Diagnosis;Ensure;experience;Faculty;Functional disorder;Funding;Future;Goals;Grant;Hispanic;Hispanic Populations;Histopathology;Image;imaging biomarker;Imaging Techniques;Impairment;improved;Inflammatory;innovation;interest;Latino Population;lectures;Liquid substance;Magnetic Resonance Imaging;Measurement;Measures;Medical Students;meetings;Methods;Microvascular Dysfunction;mixed dementia;Modeling;Motivation;multimodal neuroimaging;neuroimaging;neuroinflammation;neuropathology;neurovascular unit;New Mexico;outreach;Participant;Plasma;Population;Positron-Emission Tomography;Postdoctoral Fellow;potential biomarker;Predisposition;Prognosis;programs;progression marker;Protocols documentation;Pueblo Race;Radiology Specialty;recruit;Research;Research Personnel;Risk;Rural;Rural Population;Scanning;Skeleton;skills;Standardization;statistics;Talents;tau Proteins;Techniques;Testing;Time;tool;Training;Underrepresented Populations;Universities;vascular contributions;Vascular Dementia;Vascular Diseases;Water;Width;Work;Zuni

PROJECT_TITLE: Imaging Biomarker Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Rural Health

PI_NAMEs: GINOSSAR, TAMAR  (contact)

PROJECT_TERMS: Acceleration;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Basic Science;Behavioral Research;Biomedical Research;Blood Vessels;career;career development;Caregivers;Cerebrovascular Disorders;Clinical;Clinical Research;Clinical Trials;Communication;Communities;Competence;Dementia;design;Development;Diagnosis;Education;education research;Educational Activities;educational atmosphere;Educational Curriculum;Ethics;Faculty;Future;Generations;Goals;graduate student;Health;health inequalities;high school;hispanic community;improved;indigenous community;Inflammatory;Infrastructure;innovation;interest;investigator training;Knowledge;Lead;literacy;Medical Students;meetings;Mentors;Minority;minority engagement;Minority Groups;Minority-Serving Institution;Mission;Modeling;multidisciplinary;Nature;New Mexico;next generation;novel;outreach;Participant;Patients;Play;Positioning Attribute;Postdoctoral Fellow;pre-doctoral;Prevention;programs;recruit;Research;research and development;Research Personnel;Research Project Summaries;Research Training;Residencies;Role;Rural Community;Science;Scientist;skill acquisition;skills;symposium;Training;Training and Education;training opportunity;Training Programs;Translational Research;translational study;Underrepresented Populations;Universities;webinar;Work

PROJECT_TITLE: Research Education Component


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer

ORG_CITY: Aurora

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative The University of Colorado Paul Calabresi Award for Clinical Oncology Research trains the future leaders of cancer research in clinical trials and translational team science. This award focuses on creating diverse cohorts of clinician-scientists capable of using the advanced and emerging technologies to design clinical and ancillary trials that will improve outcomes and reduce toxicity for patients across the spectrum of diagnosis, treatment and survivorship.

PI_NAMEs: BORGES, VIRGINIA F. (contact);SLANSKY, JILL E

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: Advisory Committees;Ancillary Study;Award;Back;bench-to-bedside translation;Cancer Burden;cancer clinical trial;career;Clinical;Clinical Oncology;Clinical Research;clinical training;cohort;Colorado;Communication;Correlative Study;design;Disease;Doctor of Philosophy;early-career faculty;Ensure;Environment;experience;Faculty;flexibility;Fostering;Foundations;Funding;Future;Grant;Individual;innovation;Institution;Interdisciplinary Study;Knowledge;Learning;Malignant Neoplasms;Medical;meetings;member;Mentors;Mentorship;multidisciplinary;novel;Oncology;Outcome;Peer Review;personalized cancer therapy;professor;Program Development;programs;Publications;Qualifying;Research;Research Design;Research Personnel;Research Project Grants;role model;Running;Science;Scientist;skills;success;The University of Colorado Cancer Center;Training;Training Programs;United States National Institutes of Health;Universities;Virginia

PROJECT_TITLE: Paul Calabresi Award in Clinical Oncology Research

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: PROJECT SUMMARY Visualizing and quantifying tissue and cellular pathologies are central to understanding the pathogenesis, progression and complications of metabolic disease and related disorders, and to monitor the effectiveness of treatment. The Advanced Tissue Pathology and Imaging (ATPI) Core of the NIH-funded Columbia Diabetes Research Center provides investigators with access to confocal microscopy that is essential for their research. This application proposes to replace an aging system and to enhance the capabilities of the ATPI to meet new and growing demands for confocal microscopy with the purchase of a Zeiss LSM 900 with Airyscan 2.

PI_NAMEs: ZELTSER, LORI M (contact)

PROGRAM_OFFICER_NAME: AGGARWAL, MONIKA

PROJECT_TERMS: Aging;Area;Atherosclerosis;blood glucose regulation;Cells;cellular pathology;confocal imaging;Confocal Microscopy;Consultations;cost effective;detector;Diabetes Mellitus;Disease;energy balance;Equipment;Faculty;Foundations;Funding;Hour;Image;imaging facilities;Infrastructure;Length;Maintenance;Medical center;metabolic abnormality assessment;Metabolic Diseases;Microscopy;Monitor;non-alcoholic fatty liver disease;Obesity;Pathogenesis;Pathology;Preparation;Process;Productivity;protein expression;Research;Research Personnel;RNA;Sampling;Scientist;Structure;Subcellular structure;success;superresolution imaging;Support System;System;Techniques;Thick;Tissues;Treatment Effectiveness;United States National Institutes of Health;Universities;Visualization

PROJECT_TITLE: Zeiss LSM 900 with Airyscan 2

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CDB-J (30)]


ADMINISTERING_IC: NS

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Neurosciences;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: DALLAS

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: Project Narrative:  EZHIP-mediated PRC2 inhibition globally reduces H3K27me3 levels in cells and underlies PFA ependymoma, an epigenetically driven tumor primarily found in children. The overall goal of this search is to study a newly identified molecular mechanism, which specifically disrupts the EZHIP–PRC2 complex and thereby reshapes the unique epigenetic and metabolic pathways associated with PFA ependymoma.

PI_NAMEs: LIU, XIN  (contact)

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: Active Sites;Agreement;Amino Acid Sequence;Binding;Biochemistry;Biological Assay;Brain;brain cell;cancer cell;Catalytic Domain;Cell model;Cell Proliferation;Cells;Central Nervous System Neoplasms;Characteristics;Child;Childhood;Citric Acid Cycle;Complex;crosslink;Data;Diffuse;Dose;Drug Targeting;Enzymes;Ependymoma;Epigenetic Process;EZH2 gene;Genes;Glioma;Glycolysis;Goals;Gonadal structure;Growth;high reward;Histones;Hybrids;In Vitro;in vivo;Infant;inhibitor;Knowledge;Left;Length;Link;Lysine;Malignant Neoplasms;Mammalian Cell;Mass Spectrum Analysis;Mediating;Metabolic;Metabolic Pathway;Metabolism;Methionine;Methylation;Modeling;Molecular;molecular phenotype;Molecular Target;Mutate;Nucleosomes;oncohistone;Pathway interactions;Physiology;Polycomb;Pontine structure;Posterior Fossa;PRC1 Protein;Primary Neoplasm;Proteins;Research;restoration;Role;Series;Shapes;Site;spatial integration;Spinal Cord;structural biology;Structural Models;Structure;Surface;synergism;Testing;therapeutic target;Toddler;tumor;tumorigenesis

PROJECT_TITLE: Understanding Molecular Crosstalk Between EZHIP and PRC2 in PFA Ependymoma

STUDY_SECTION: MG

STUDY_SECTION_NAME: Molecular Genetics Study Section[MG]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Pediatric;Social Determinants of Health

ORG_CITY: CHICAGO

ORG_NAME: LURIE CHILDREN'S HOSPITAL OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE This project aims to develop and evaluate a transdiagnostic gender-affirmative CBT-based digital mental health intervention for transgender and nonbinary (TNB) adolescents. Leveraging technology to deliver culturally tailored, evidence-based mental health interventions to TNB adolescents holds great promise to reduce health disparities and improve mental health outcomes in this health disparity population with documented barriers to accessing competent mental health care.

PI_NAMEs: CHEN, DIANE  (contact)

PROGRAM_OFFICER_NAME: BURSTEIN, MARCY ELLEN

PROJECT_TERMS: Address;Adolescent;Adult;Affective;Aftercare;aged;Anxiety;attentional control;Behavioral;Birth;cisgender;Cognitive;Cognitive Therapy;Collaborations;Communities;Compensation;Data;Development;Diagnostic;digital;digital mental health;Discrimination;Disease;Dropout;Effectiveness;effectiveness/implementation trial;Ensure;Environment;Equity;evidence base;Evidence based intervention;expectation;experience;feasibility testing;Future;Gender;gender affirmation;Gender Identity;gender minority;Geographic Locations;Goals;group intervention;health disparity;health disparity populations;Health Personnel;high school;Human;implementation context;implementation design;implementation determinants;improved;Individual;Intervention;Knowledge;Lesbian Gay Bisexual Transgender Queer;Mental Depression;Mental Health;Mental Health Services;Minority;minority stress;mobile delivery;Modification;nonbinary;novel strategies;Outcome;overtreatment;participant retention;patient privacy;Patient Recruitments;Patient Self-Report;Persons;Population;prototype;psychological distress;Randomized;Reduce health disparities;Reporting;Research;Resources;Risk;rural area;Safety;satisfaction;School-Age Population;screening;sex;social;social stigma;Stigmatization;stressor;suicidal;Suicide attempt;symptom treatment;Symptoms;Technology;Testing;Therapeutic Intervention;transgender;transphobia;Treatment outcome;United States;usability;user centered design;Youth

PROJECT_TITLE: Development and Preliminary Trial of a Digital Transdiagnostic CBT Intervention for Transgender Adolescents

STUDY_SECTION: EMHI

STUDY_SECTION_NAME: Effectiveness of Mental Health Interventions Study Section[EMHI]


NIH_SPENDING_CATS: Cancer;Orphan Drug;Pediatric;Pediatric Cancer;Prevention;Rare Diseases

ORG_CITY: MEMPHIS

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

ORG_STATE: TN

PHR: NARRATIVE The Pediatric Oncology Career Development Program at St. Jude is designed to provide protected time for early career faculty to conduct patient-oriented research focused on cancers in children and adolescents and engage in career development programming to facilitate transition to successful careers as independent clinical investigators. Scholars will be mentored by a team of clinical, basic/translational, or epidemiological science and biostatistician faculty, engage in didactic and experiential learning in biostatistics, clinical trial design, as well as diversity, equity, and inclusion, and have unique opportunities to interact with faculty and scholars at other institutions to present their research and further advance their careers.

PI_NAMEs: FOX, ELIZABETH ;ROBERTS, CHARLES  (contact)

PROGRAM_OFFICER_NAME: BIAN, YANSONG

PROJECT_TERMS: Academic Training;Adolescent;Area;Award;Basic Science;Cancer Center;Cancer Control;cancer diagnosis;Cancer Survivorship;career development;Clinical;clinical care;clinical investigation;Clinical Research;Clinical Trials;combat;Combination Drug Therapy;Comprehensive Cancer Center;Dedications;design;Development;Diagnosis;Enrollment;Environment;Epidemiologist;Evaluation;Faculty;Feedback;Fellowship Program;genome sciences;Grant;Hematology;Home;innovation;Institution;instructor;interest;Intervention Trial;investigator-initiated trial;Late Effects;leadership development;lectures;Malignant Childhood Neoplasm;Malignant Neoplasms;Master of Science;Mentors;Mission;Monitor;Newly Diagnosed;next generation;Oncology;patient oriented;patient oriented research;Patients;Pediatric Oncology;Pediatrics;Positioning Attribute;Process;Productivity;Program Development;Program Effectiveness;programs;Publications;Research;Research Personnel;Research Project Grants;Resources;Role;Saint Jude Children's Research Hospital;Scientist;Seminal;Series;Therapeutic Trials;Time;Training;training opportunity;translational medicine;Translational Research;translational scientist;treatment effect;trial design;visiting scholar


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Services;Patient Safety;Prevention;Primary Health Care;Rehabilitation;Social Determinants of Health

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE Despite advances in understanding and preventing health care problems faced by cancer survivors, little has changed in the delivery of survivorship care. With the lack of a planned and formal transition of the cancer survivor from the cancer care to the primary care team, non-cancer-related comorbidities are poorly managed. The proposed study aims to use a multi-level intervention including patient and PCP strategies to optimize the management of CVD comorbidities during and after cancer therapy.

PI_NAMEs: OEFFINGER, KEVIN CHARLES (contact);ZULLIG, LEAH L.

PROGRAM_OFFICER_NAME: JENSEN, ROXANNE ELAINE

PROJECT_TERMS: Acute;Adherence;Adult;Affect;Aftercare;Aging;Attention;Back;Behavior;Behavioral Sciences;Biometry;Breast;cancer care;Cancer Center;Cancer Patient;cancer recurrence;cancer risk;Cancer Survivor;cancer survivorship care;cancer therapy;Cardiovascular Diseases;cardiovascular disorder risk;care coordination;care costs;care delivery;Caring;Chronic;Clinic;Clinical;Colorectal;Communication;Communities;comorbidity;comparison intervention;Data;Diet;Education;Effectiveness;effectiveness evaluation;Electronic Health Record;Emergency department visit;empowerment;Endometrial;Enrollment;Exercise;experience;financial toxicity;follow-up;Genetic;Goals;group intervention;Growth;Head and neck structure;Health;health care delivery;Healthcare;Healthcare Systems;hypercholesterolemia;Hypertension;improved;Individual;Institute of Medicine (U.S.);Interdisciplinary Study;Internal Medicine;Intervention;Interview;Laboratories;Length of Stay;Letters;Life Style;Malignant Neoplasms;Measurement;Measures;Mediating;Medical;Medical Oncologist;medication compliance;member;Methods;mortality risk;Newly Diagnosed;Non-Insulin-Dependent Diabetes Mellitus;Non-Small-Cell Lung Carcinoma;North Carolina;Oncologist;Oncology;Outcome;Outpatients;Participant;Patient Care;patient oriented;patient-clinician communication;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;Pharmacy facility;Phase;Population;Population Heterogeneity;Population Sciences;prevent;Primary Care;primary care patient;primary care provider;primary care team;primary outcome;Productivity;Prostate;Provider;provider communication;Randomized;Randomized, Controlled Trials;Reporting;Research;Research Design;Risk;risk stratification;Seminal;Sequential Multiple Assignment Randomized Trial;Series;sociodemographics;Specialist;Survival Rate;Survivors;survivorship;team-based care;theories;Therapeutic;Time;Titrations;Touch sensation;Training;treatment as usual;trial design;Uninsured Medical Expense;Visit;webinar

PROJECT_TITLE: Onco-primary care networking to support TEAM-based care - the ONE TEAM Study


ADMINISTERING_IC: OH

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH

ORG_CITY: FARMINGTON

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT

ORG_STATE: CT

PHR: PROJECT NARRATIVE (Overall section) The CPH-NEW Total Worker Health® (TWH) Center of Excellence will conduct research and outreach activities to advance worker safety, health, and well-being using participatory worker-centered methods that engage workers in organizational decision-making to advance worker well-being. Research projects focus on the well-being, work-life balance, and organizational support of teachers; novel implementation strategies for health and safety promotion among healthcare workers; and the crisis preparedness of small- and medium- sized enterprises. The Center will also translate research to produce evidence-based workplace tools and integrated programs that can be used to promote health and well-being for all working people.

PI_NAMEs: CAVALLARI, JENNIFER M (contact)

PROJECT_TITLE: CPH-NEW IV - Total Worker Health


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: OTHERS

ORG_CITY: LOS ANGELES

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: OVERALL - PROJECT NARRATIVE The programs of the SCERC impact occupational health and safety in three ways: Our graduates contribute directly to worker safety and health through their employment as professionals in the field and many go on to assume leadership positions in business and various state and federal agencies. Our research contributes to longer term improvements in worker health through improved understanding of workplace exposures, health effects, and their control. Our Outreach and Continuing Education Programs facilitate the translation of research results into actual occupational and public health and safety practice.

PI_NAMEs: JONES, RACHAEL MARY (contact)

PROJECT_TITLE: Southern California Education and Research Center


ORG_CITY: HOUSTON

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PI_NAMEs: FELKNOR, SARAH A. (contact)

PROJECT_TITLE: Southwest Center for Occupational and Environmental Health


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Arthritis;Clinical Research

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

ORG_STATE: MA

PHR: Project Narrative Neutrophils protect against infection but also contribute to tissue injury in diseases such as inflammatory arthritis and vasculitis. We show that two related neutrophil surface proteins, Ly6G in mice and CD177 in humans, alter integrin-dependent neutrophil migration and distinguish distinct neutrophil subphenotypes. We test the possibility that these Ly6-family molecules provide unique insight into neutrophil function and heterogeneity in a manner that may expose opportunities for safe therapeutic targeting.

PI_NAMEs: NIGROVIC, PETER A (contact)

PROGRAM_OFFICER_NAME: MAO, SU-YAU

PROJECT_TERMS: Adult;Anti-Bacterial Agents;Arthritis;Attenuated;Award;biobank;Bioinformatics;Biological Assay;Biology;Blood;Blood specimen;cell motility;Cells;Child;cytokine;Data;Development;differential expression;Disease;Endothelium;Ensure;Exhibits;Experimental Arthritis;Family;Family member;Gene Expression;Genes;Genetic Transcription;Goals;Health;Heterogeneity;Human;Image;Immune;In Vitro;in vivo;Infection;Inflammation;Inflammatory;Inflammatory Arthritis;Inflammatory Infiltrate;insight;Integrins;Interruption;Investigation;Joints;Laboratories;Leukotrienes;Ligation;Link;Liquid substance;Lung;Mediating;Membrane Proteins;Metabolism;migration;Modeling;Molecular;molecular imaging;mouse model;Mucocutaneous Lymph Node Syndrome;Mus;Myelogenous;nanoscale;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;neutrophil;novel;Outcome;Pathogenicity;Pathway interactions;Peritoneum;Phenotype;Positioning Attribute;Production;Productivity;Protein Dynamics;Proteins;Recycling;Research Personnel;Rheumatism;Role;Sampling;Signal Transduction;single-cell RNA sequencing;Sorting;Sterility;Stimulus;Surface;System;Talin;Testing;Therapeutic;therapeutic target;tissue injury;tool;transcriptome sequencing;Vasculitis

PROJECT_TITLE: Ly6 family members in neutrophil biology

STUDY_SECTION: III

STUDY_SECTION_NAME: Innate Immunity and Inflammation Study Section[III]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: BIRMINGHAM

ORG_NAME: BIRMINGHAM VA MEDICAL CENTER

ORG_STATE: AL

PHR: Vascular calcification and stiffness are hallmarks of diabetic vascular disorder, a prevalent cardiovascular complication in the Veteran's population that leads to increased morbidity and mortality. Disrupted circadian clock is a common issue in military personnel, which affects many of our Veterans. The proposal will establish a novel paradigm underlying circadian regulation of O-GlcNAcylation-mediated signaling in diabetic vascular calcification. The mechanistic insights learned from this proposal can not only advance our understanding of the basic mechanisms governing pathogenesis of diabetic vascular calcification, but also provide molecular insights into the development of novel strategy or drugs for prevention and therapy of these diabetic complications.

PI_NAMEs: CHEN, YABING  (contact)

PROJECT_TERMS: Acceleration;Affect;Animal Model;Animals;Aorta;ARNTL gene;Arteries;Blood Vessels;calcification;Cardiovascular system;Cell Physiology;circadian;Circadian Dysregulation;circadian pacemaker;circadian regulation;Circadian Rhythms;Clinical;Complication;Complications of Diabetes Mellitus;Darkness;Development;Diabetes Mellitus;diabetic;Diabetic Angiopathies;diabetic cardiomyopathy;Diabetic mouse;Disease Progression;Dose;Echocardiography;feeding;FOXO1A gene;Genes;Health;High Fat Diet;Hyperglycemia;improved;In Vitro;in vivo;insight;Knowledge;Learning;Light;Lipids;Mass Spectrum Analysis;Mediating;Military Personnel;military veteran;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;novel;novel strategies;novel therapeutics;Outcome;Outcome Study;Oxidative Stress;Pathogenesis;Pathologic;Physiological;Post-Translational Protein Processing;Prevention;Proteins;Proteomics;Proto-Oncogene Proteins c-akt;Regulation;Reporting;Role;Signal Induction;Signal Transduction;Smooth Muscle Myocytes;Streptozocin;Time;tool;United States Department of Veterans Affairs;Up-Regulation;Vascular calcification;Vascular Diseases;Vascular Smooth Muscle;Veterans

PROJECT_TITLE: Molecular Regulation of Vascular Calcification in Diabetes


ADMINISTERING_IC: FD

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_DEPT: PHYSIOLOGY

PHR: NARRATIVE  The proposal requests partial support for the 14th through the 18th Annual Meetings of the Organization for the Study of Sex Differences (OSSD). The 14th Annual Meeting, entitled “Sex Differences Across the Lifespan”, will be held in Marina del Rey, Los Angeles, California, in May 4-7, 2020, with a particular focus on the effect of sex on age-related diseases. The OSSD is a scientific membership society with the mission to enhance the knowledge of sex/gender differences in human health and disease by facilitating interdisciplinary communication and collaboration among scientists and clinicians from diverse backgrounds.

PI_NAMEs: ARNOLD, ARTHUR P (contact)

PROGRAM_OFFICER_NAME: HARTER, KRYSTAL

PROJECT_TITLE: Organization for the Study of Sex Differences Annual Meetings


ADMINISTERING_IC: EY

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Clinical Research;Data Science;Disability Research;Eye Disease and Disorders of Vision;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: TEMPE

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

ORG_STATE: AZ

PHR: Project Narrative The proposed project is relevant to public health because it develops artificial intelligence–driven tools to generate descriptions for online videos, making them accessible to blind and low vision individuals . This is essential for their health and wellbeing, as these videos contain critical information related to all facets of life. Thus, the proposed research is relevant to the part of the NIH’s mission that pertains to applying knowledge to enhance health.

PI_NAMEs: FAZLI, POOYAN  (contact)

PROGRAM_OFFICER_NAME: WIGGS, CHERI

PROJECT_TERMS: Address;Artificial Intelligence;assistive robot;blind;Breeding;Canis familiaris;Collaborations;Communication;Communities;community engagement;computer human interaction;Computer Vision Systems;Data Set;Decision Making;design;Diagnosis;digital;diverse data;Education;Emotional;Employment;Ensure;Environment;Ethics;Face;Feeling;Future;German population;global health;Goals;Health;Human;Human Volunteers;human-in-the-loop;Image;improved;Individual;innovation;Internet;Intervention;Knowledge;large scale data;Life;Machine Learning;Mission;Modernization;Natural Language Processing;novel;open source;Outcome;Output;Pathway interactions;Personal Satisfaction;Persons;Positioning Attribute;Public Health;Research;response;Safety;satisfaction;Self-Help Devices;social;social exclusion;System;Time;tool;Training;United States;United States National Institutes of Health;virtual;Vision;vision rehabilitation;Visual;Visual impairment;visual information;volunteer;Work

PROJECT_TITLE: From Human-Powered to Automated Video Description for Blind and Low Vision Users


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Project Narrative At least two years of mentorship and training in research approaches and techniques are absolutely essential as graduates of dermatology training programs or PhD programs transition from student to independent biomedical scientists. The Harvard Dermatology Training grant provides this support, partnering the most promising trainees with accomplished and supportive research mentors who will sponsor their work in their laboratories. We wish to continue to build on the extraordinary success that this program has achieved over the last 45 years, in training the best and the brightest biomedical scientists of tomorrow.

PI_NAMEs: KUPPER, THOMAS S. (contact)

PROGRAM_OFFICER_NAME: VINCENT, ISAAH S

PROJECT_TERMS: Dermatology;Grant;Training

PROJECT_TITLE: Dermatology Training Grant


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: CHAPEL HILL

ORG_DEPT: BIOLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: NARRATIVE This program will investigate the role of secondary and tertiary RiboNucleic Acid (RNA) structure in controlling gene expression. We will use experimental data to compute models of how disease-causing genetic variants alter the precursor and mature messenger RNA structures. These models will discover and validate novel mechanisms by which RNA structure change causes human genetic disease.

PI_NAMEs: LAEDERACH, ALAIN T (contact)

PROGRAM_OFFICER_NAME: MASKERI, BAISHALI

PROJECT_TERMS: 3-Dimensional;Acylation;Alleles;Biological;Biological Assay;Cells;Chemical Structure;Chemicals;crosslink;Data;Disease;disease model;Elements;Etiology;experimental study;Gene Expression;Gene Expression Regulation;Genetic Diseases;genetic variant;genome-wide;Goals;human disease;Human Genetics;human tissue;Hybrids;Hydroxyl Radical;in vivo;innovation;Maps;Measures;Messenger RNA;Modeling;Modification;Molecular;Mutation;novel;Organism;posttranscriptional;Primer Extension;Process;programs;Proteins;Reagent;Reporter;Research;RNA;RNA Stability;RNA, Messenger, Splicing;RNA-Directed DNA Polymerase;Role;Sampling;Structure;technological innovation;Technology;transcriptome;Translations;Untranslated RNA;Variant;Viral Genome;Virus;Work

PROJECT_TITLE: Variant induced RNA structure change in human genetic disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-S(55)R]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

ORG_CITY: BALTIMORE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: Project Narrative Learning, memory and cognition are all dependent on communication between neuronal cells within the brain. The goal of this proposal is to improve our current understanding of the structure underlying this precise transcellular communication. Elucidating the role of key proteins involved in this process may improve our understanding of many neuropsychiatric disorders and inform their treatments.

PI_NAMEs: DEMARCO, EMILY M. (contact)

PROGRAM_OFFICER_NAME: MATTHEWS, MARGUERITE

PROJECT_TERMS: Action Potentials;Acute;Affect;AMPA Receptors;Anxiety Disorders;autism spectrum disorder;Binding;Brain;career;Cell Adhesion Molecules;Cells;Chronic;Cognition;Communication;Compensation;Confocal Microscopy;density;Development;DLG4 gene;DNA;Electrophysiology (science);Engineering;Evoked Potentials;Excitatory Synapse;Experimental Designs;experimental study;extracellular;Extracellular Domain;Family;Fellowship;Genetic;Genetic Complementation Test;Glutamate Receptor;Goals;Hippocampus;Image;improved;insight;knock-down;Knock-out;Lead;Learning;live cell imaging;Measures;Mediating;member;Memory;Mental Depression;Methodology;Microscopy;Modeling;Molecular Biology;mutant;N-Methyl-D-Aspartate Receptors;N-Methylaspartate;N-terminal;nano;nanocolumn;nanoscale;Nanostructures;Neurons;neuropsychiatric disorder;Neurosciences;neurotransmitter release;novel;Optics;patch clamp;Pathology;Peptide Hydrolases;Physiology;Play;Positioning Attribute;postsynaptic;presynaptic;Probability;Process;protein complex;Protein Family;Protein Tyrosine Phosphatase;Proteins;receptor;Receptor Activation;receptor function;Regulation;Research Personnel;Resistance;Resolution;response;Role;scaffold;Scaffolding Protein;single molecule;Site;Structure;superresolution microscopy;Synapses;Synaptic Cleft;Synaptic Transmission;synaptogenesis;Techniques;Testing;Training;transmission process;Universities;Vesicle;vesicular release;Work

PROJECT_TITLE: Elucidating the dynamic role of PTPsigma in synaptic nano-organization and NMDA receptor function


NIH_SPENDING_CATS: Aging;Biomedical Imaging;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences

ORG_CITY: LA JOLLA

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative Glaucoma is a leading cause of permanent vision loss in the United States and worldwide where the only treatment is to lower intraocular pressure (IOP). IOP is largely governed by how aqueous humor (the fluid in the eye) exits through drainage pathways; and recent discoveries have uncovered that aqueous humor outflow (AHO) is not static and unchanging but instead shows previously unappreciated behaviors such as dynamic variable outflow (DVO): including dynamic, segmental, and rescuable characteristics. Specifically, in this proposal we work to 1) discover the regulation of DVO and study how glaucoma 2) surgeries and 3) pharmacological drugs alter or are impacted by DVO in different parts of the eye as a way to improve current treatments and help innovate future ones.

PI_NAMEs: HUANG, ALEX  (contact)

PROGRAM_OFFICER_NAME: SONG, HONGMAN

PROJECT_TERMS: Acetylcholine;Affect;Angiography;Anterior;aqueous;Aqueous Humor;Area;Behavior;Biology;Blindness;Brain Death;Bypass;Carbachol;Cell Death;Characteristics;cholinergic;Ciliary Muscle;clinical care;Complex;Coupled;Cytoskeleton;Disease;Distal;Drainage procedure;Drug Delivery Systems;drug development;Drug Formulations;Drug Targeting;Endothelin-1;Engineering;Excision;experimental study;Eye;FDA approved;Future;Genomics;Glaucoma;glaucoma surgery;Goals;Grant;Histologic;Human;human model;human tissue;Image;Imaging Device;improved;in vivo;Individual;individual patient;innovation;Institutional Review Boards;kinase inhibitor;Laboratories;Liquid substance;Location;Measures;Methods;Molecular;Movement;Muscarinics;National Eye Institute;Nitric Oxide;novel;novel therapeutics;Operating Rooms;Operative Surgical Procedures;Optical Coherence Tomography;Optics;Organ Donor;Pathway interactions;Patient Care;Patients;Pattern;Perfusion;personalized medicine;Pharmaceutical Preparations;pharmacologic;Pharmacological Treatment;Physiologic Intraocular Pressure;Physiological;Pilocarpine;Process;Proteomics;Protocols documentation;real-time images;Regulation;Relaxation;Research;Research Personnel;Resources;response;Retinal Ganglion Cells;Rho-associated kinase;Risk Factors;Route;Science;structural imaging;Structure of sinus venosus of sclera;Study models;success;System;Time;tool;Trabecular meshwork structure;Tracer;Translating;United States;United States National Institutes of Health;Veins;Venous;Vision;Work

PROJECT_TITLE: Dynamic Variable Aqueous Humor Outflow and Glaucoma Therapies in the Human Eye


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Infectious Diseases

ORG_DEPT: OTOLARYNGOLOGY

PHR: PROJECT NARRATIVE Relevance to Public Health: Training physicians in Otolaryngology to perform research is of critical importance to the future of the field as well as patient care. Only through research that is performed in a rigorous manner by highly trained physician-scientists will diseases be understood and new treatments developed and validated. The proposed training will prepare Otolaryngologists for careers in that include high-quality research.

PI_NAMEs: FRIEDMAN, RICK A (contact)

PROGRAM_OFFICER_NAME: RIVERA-RENTAS, ALBERTO L

PROJECT_TERMS: academic preparation;Address;Area;Attention;Basic Science;Biomedical Research;career;Career Choice;Clinical;Clinical Research;Clinical Sciences;clinical training;Collaborations;Communicable Diseases;Conflict (Psychology);Counseling;data quality;Development;Disease;Education;Education Projects;education research;Ensure;Evidence Based Medicine;experience;Experimental Designs;Fellowship;Female;Funding;Future;Genomic medicine;Goals;Grant;Head and neck structure;Healthcare;Immune;Immunologics;Immunology;Immunotherapy;Inflammatory;Institution;Instruction;Length;Malignant Neoplasms;Manuscripts;Mediating;medical schools;medical specialties;Medicine;Mentors;Methods;Minority;Mission;Molecular;Molecular Biology;National Institute on Deafness and Other Communication Disorders;Natural Immunity;Otolaryngologist;Otolaryngology;pathogen;Patient Care;Patients;Physicians;Play;Preparation;programs;Public Health;receptor;recruit;Reproducibility;Research;Research Ethics;Research Personnel;Research Project Grants;Research Training;Residencies;responsible research conduct;Role;Science;Scientist;skills;Structure;success;Supervision;Surgical Specialties;symposium;Teacher Professional Development;Techniques;Therapeutic;Time;Training;Training Programs;Translational Research;Underrepresented Populations;virology;Virus Diseases;Wages;Work;Writing

PROJECT_TITLE: Otolaryngology Training in Immunology, Virology and Molecular Biology


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Eating Disorders;Mental Health;Neurosciences;Nutrition

ORG_CITY: PHILADELPHIA

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative Loss of control eating is a key feature of many eating disorders, and loss of control in general is pervasive in psychiatric disease, demanding an improved understanding of its physiology. Pathophysiological understanding of loss of control eating is limited to preclinical and neuroimaging evidence of dysfunctional corticolimbic and striatal circuits, however, invasive animal studies are yet to be confirmed in humans and neuroimaging methods lack the spatiotemporal resolution to inform new treatments. For the first time in the field, we will use exquisite tools to invasively probe aspects of loss of control eating (i.e. anticipation of palatable food, cravings, etc) in subjects implanted with depth electrodes in the nucleus accumbens attached to an intracranial deep brain stimulation device capable of sensing to pave the path forward more refined, understanding of the neuroanatomy and physiologic underpinnings of loss of control.

PI_NAMEs: HALPERN, CASEY HARRISON (contact)

PROGRAM_OFFICER_NAME: TILGHMAN, JESSICA IRENE

PROJECT_TERMS: Adult;Anatomy;Animals;bariatric surgery;Behavior Control;Behavioral;behavioral response;Bilateral;Binge eating disorder;BRAIN initiative;cohort;Corpus striatum structure;craving;Cues;Data;data archive;Data Set;Deep Brain Stimulation;Detection;Devices;Diagnostic;Dorsal;Eating;Eating Behavior;Eating Disorders;Electrodes;Enrollment;Exhibits;feasibility trial;Food;food craving;Frequencies;Graph;Home;Human;human subject;Hunger;Implant;implantation;improved;insight;interest;Left;loss of control over eating;Mediating;Mental disorders;Methods;Mus;neural;Neuroanatomy;neuroimaging;Nucleus Accumbens;Operative Surgical Procedures;Outcome;Participant;Pattern;Physiological;Physiology;pre-clinical;preclinical study;primary endpoint;Psychiatry;Recurrence;Research Personnel;Resolution;response;Role;Safety;Satiation;Series;Serious Adverse Event;Signal Transduction;Source;spatiotemporal;Specificity;Sum;System;Time;tool;Ventral Lateral Thalamic Nucleus;Weight Gain;Work

PROJECT_TITLE: Investigating the role of nucleus accumbens delta signaling in loss of control


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_DEPT: SURGERY

PHR: Project Narrative Achieving tolerance remains the most important goal in transplantation. The significance of the current proposal is that it will define the function and mechanisms of specialized stromal cells and stromal structures in the lymph node that determine transplantation tolerance, and how they determine the choice between immunity versus tolerance. The findings from these investigations will have general applicability to other areas of immunology such as infection, vaccination, and autoimmunity.

PI_NAMEs: BROMBERG, JONATHAN S (contact)

PROGRAM_OFFICER_NAME: KEHN, PATRICIA J

PROJECT_TERMS: adaptive immunity;Adhesions;Alloantigen;Allografting;Antibodies;Apoptotic;Area;Autoimmunity;Binding;CD8-Positive T-Lymphocytes;Cell Maturation;cell motility;Cells;chemokine;Chronic;Cicatrix;cohort;Colitis;Cues;Data;Dendritic Cells;draining lymph node;effector T cell;Endothelium;Environment;Event;Fiber;FOXP3 gene;Funding;Gatekeeping;Generations;Goals;Graft Enhancements;Graft Survival;Heart Transplantation;High Endothelial Venule;Immune;Immune response;Immunity;Immunologics;Immunology;Immunosuppression;Infection;Infiltration;Inflammation;Inflammatory;Inflammatory Response;insight;Integrin alpha6;interstitial;Intervention;Investigation;Knock-out;Knockout Mice;Laminin;laminin alpha5;Ligands;lymph nodes;Macrophage;migration;Modeling;Mus;Natural Immunity;Outcome;Pathologic;Pathway interactions;pharmacologic;prevent;receptor;Regulatory T-Lymphocyte;response;Reticular Cell;Role;Spleen;Stromal Cells;Structure;T cell differentiation;T-Cell Proliferation;T-Lymphocyte;TNFRSF5 gene;TNFSF5 gene;trafficking;Transcriptional Regulation;Transgenic Organisms;Transplantation;Transplantation Tolerance;Tumor Immunity;Vaccination;α-Dystroglycan

PROJECT_TITLE: Lymph Node Structure and Function in Tolerance: Role of Laminins

STUDY_SECTION: TTT

STUDY_SECTION_NAME: Transplantation, Tolerance, and Tumor Immunology Study Section[TTT]


ORG_CITY: SEATTLE

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Public Health Narrative The COPII vesicle pathway, the focus of this grant, is essential for normal cellular function. It is essential for secretion of hormones and antibodies, and is subverted for the assembly of viruses including HIV. Le- sions in genes encoding components of this pathway cause a variety of human diseases. The fundamental research in this Project may ultimately help to guide development of therapeutics to treat viral infections and genetic lesions that cause COPII-associated diseases.

PI_NAMEs: MERZ, ALEXEY JARRELL (contact)

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TERMS: Address;Antibodies;Area;Biochemical;Biological Assay;Biophysics;Cell Extracts;Cell Physiology;Cells;Chemicals;Coated vesicle;cofactor;Complex;Consumption;Data;Disease;Dissociation;Docking;Elements;Endoplasmic Reticulum;experimental study;functional genomics;fundamental research;Genes;Genetic;Genetic Screening;Genomic approach;Golgi Apparatus;Golgi Targeting;golgin;Grant;Guanine Nucleotide Exchange Factors;Guanosine Triphosphate Phosphohydrolases;Hand;HIV;Hormone secretion;human disease;insight;Lesion;Lipids;Measures;Mediating;Membrane;Membrane Protein Traffic;Modeling;Molecular Conformation;Nucleotides;Pathway interactions;Phosphatidylinositols;prevent;Process;Productivity;Proteins;Public Health;Publishing;rab GTP-Binding Proteins;reconstitution;Recycling;Research;Saccharomycetales;SNAP receptor;Sorting;System;Testing;therapeutic development;TRAPP transport protein particle;Vesicle;vesicle transport;Virus Assembly;Virus Diseases;virus genetics;Yeasts

PROJECT_TITLE: Dynamics of Endomembrane Docking and Fusion

STUDY_SECTION: MBPP

STUDY_SECTION_NAME: Membrane Biology and Protein Processing Study Section[MBPP]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Contraception/Reproduction;Endocrine Disruptors;Estrogen;Infertility;Women's Health Research

ORG_CITY: NEWARK

ORG_DEPT: CHEMISTRY

ORG_NAME: NEW JERSEY INSTITUTE OF TECHNOLOGY

ORG_STATE: NJ

PHR: PROJECT NARRATIVE Exposure to endocrine disrupting chemicals such as phthalates contributes to increased rates of human infertility and reproductive disorders worldwide. The proposed research will fill a public health need by developing a method to investigate the mechanisms through which endocrine disrupting chemicals such as phthalates act to cause toxicity in the ovary. The results of this project will facilitate the development of safer alternative chemicals and contribute to the identification of new treatments to protect the ovary from environmental chemical exposure.

PI_NAMEs: WARNER, GENOA R (contact)

PROGRAM_OFFICER_NAME: SCHUG, THADDEUS

PROJECT_TERMS: Acceleration;Affinity;Award;Behavior;Biochemical;Biological;Biology;building materials;career;career development;Cell Culture Techniques;Cell membrane;cell type;Cells;Cessation of life;Chemical Structure;Chemicals;Chemistry;Child;chromatin immunoprecipitation;Complex;consumer product;Culture Media;Data;Development;Development Plans;Dioxins;Disease;DNA-Binding Proteins;Endocrine disruption;Endocrine Disruptors;Environment;environmental chemical exposure;Environmental Health;Enzymes;Equipment;Esters;exposed human population;Exposure to;Family;Female;Female infertility;Gene Expression;General Population;Genes;Genetic Transcription;Genomics;Goals;Hormones;Human;Hydrocarbons;Illinois;Image;imaging modality;In Vitro;Individual;Industrialization;Infertility;innovation;insight;Label;Length;lipophilicity;Mass Spectrum Analysis;Massive Parallel Sequencing;Mediating;Medical;men;Mentors;Mentorship;Metabolism;Methods;Modernization;Molecular;mouse model;Nature;novel;Oocytes;Ovarian;Ovarian aging;Ovarian Follicle;Ovarian Tissue;Ovary;ovotoxicity;personal care products;Phase;phthalates;Phthalic Acids;Plasticizers;Population;Postdoctoral Fellow;Premature Ovarian Failure;Prevalence;Prevention;programs;Property;Proteins;Public Health;receptor;Reproduction;reproductive;Reproductive Biology;reproductive organ;reproductive system disorder;Research;Research Personnel;Research Proposals;Research Training;Sampling;screening;Side;skills;small molecule;Solvents;Structure;Techniques;Technology;Testing;Tissues;Toxic effect;toxicant;Toxicology;Toy;Training;transcription factor;Universities;Urine;Visualization;Woman

PROJECT_TITLE: Mechanisms of Phthalate Toxicity in the Ovary

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

PHR: PROJECT NARRATIVE: In cardiac ischemia/reperfusion (I/R) injury, approximately 50% of cell death is due to reperfusion injury, for which there are no standard clinical therapies. This proposal will study the importance of two biological processes using specific FDA approved medicines to induce autophagy and PGC1-mediated mitochondrial biogenesis during reperfusion injury. This study may lead to a new therapy for heart attack patients that results in less heart damage and a better quality of life for these patients.

PI_NAMEs: XIE, MIN  (contact)

PROGRAM_OFFICER_NAME: WONG, RENEE P

PROJECT_TERMS: Affect;attenuation;Autophagocytosis;Biogenesis;Biological Process;Brain;Cardiac;Cardiac Myocytes;cardioprotection;Cell Death;Cell Respiration;Clinical;Data;Excision;FDA approved;gain of function;Genetic;genetic manipulation;Heart;heart damage;Histone Deacetylase Inhibitor;Homeostasis;Impairment;improved;Infarction;Ischemia;Kidney;Knowledge;loss of function;Mediating;Medicine;Mitochondria;mitochondrial autophagy;Modeling;Molecular;mouse model;Mus;Myocardial Infarction;Myocardial Ischemia;Myocardial Reperfusion;novel therapeutics;overexpression;Parkin;Parkinson Disease;Pathway interactions;patient population;Patients;Peptides;pharmacologic;PPAR gamma;Process;Proteins;Quality Control;Quality of life;receptor;Recycling;Regulation;Reperfusion Injury;Reperfusion Therapy;Role;Signal Transduction;small molecule;Testing;Time;transcription factor;ubiquitin ligase;Vorinostat

PROJECT_TITLE: Enhancing Autophagy and Mitochondrial Biogenesis to Mitigate Cardiac Reperfusion Injury

STUDY_SECTION: MIM

STUDY_SECTION_NAME: Myocardial Ischemia and Metabolism Study Section[MIM]


NIH_SPENDING_CATS: Cancer;Congenital Structural Anomalies;Genetics;Pediatric;Pediatric Cancer;Rare Diseases;Skin Cancer;Wound Healing and Care

ORG_CITY: MINNEAPOLIS

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Public Health Relevance Squamous cell carcinoma arising in chronic wounds is the leading cause of death in patients with recessive dystrophic epidermolysis bullosa. This project aims to elucidate the mechanisms underlying cancer initiation in these patients by interrogation of HMGB1, a protein involved in both inflammation and genome maintenance. The results from this study will provide a foundation for new drug targets in this fragile patient population and will shed new light on carcinogenesis in the broader context of inflammatory disease.

PI_NAMEs: BUI, KACEY LINNEA GUENTHER (contact)

PROGRAM_OFFICER_NAME: ADAMS, GREGORY

PROJECT_TERMS: Acceleration;Address;Age;Alleles;Attenuated;attenuation;Basal cell carcinoma;Basement membrane;Binding;Biological Markers;Biological Process;cancer initiation;carcinogenesis;career;career development;Cause of Death;cell injury;Cell Line;Cell Nucleus;cell transformation;chemical carcinogenesis;Childhood;Chromatin;chronic wound;Cicatrix;Clinical;Code;COL7A1;Collagen Type VII;Complex;Cutaneous;cytokine;Defect;Development;Diagnosis;Disease;DNA;DNA Binding;DNA biosynthesis;DNA Damage;DNA Repair;DNA Repair Enzymes;DNA Repair Pathway;early onset;effective therapy;Epidermolysis Bullosa;Epidermolysis Bullosa Dystrophica;Epithelial Cells;Exposure to;Extracellular Matrix;Extracellular Space;Fellowship;Fibrosis;Foundations;Genes;Genetic Diseases;Genetic Skin Diseases;Genetic Transcription;Genome;Genome Stability;Genomic Instability;Goals;healing;HMGB1 gene;Human;improved;In Vitro;in vivo;in vivo Model;Incidence;Inflammation;Inflammatory;inflammatory milieu;Inflammatory Response;inhibitor;Innate Immune Response;keratinocyte;Knowledge;Life;life span;Location;Maintenance;Malignant Neoplasms;Melanoma Cell;Membrane Proteins;Mentorship;Minnesota;Molecular;mouse model;Mus;Mutagens;mutant;Mutation;Nature;new therapeutic target;Nuclear;Nuclear Protein;Oncologist;Oxidation-Reduction;Pathogenesis;Pathway interactions;patient population;Patients;Pattern;Pediatric Hematologist;Pediatric Oncologist;pediatric patients;Physicians;Play;Positioning Attribute;Post-Translational Protein Processing;prevent;Prevention;primary endpoint;Production;Productivity;protein function;protein protein interaction;Proteins;public health relevance;rare genetic disorder;receptor for advanced glycation endproducts;recruit;Research;response;Role;Scientist;Serum;Severity of illness;Signal Pathway;Signal Transduction;Site;Skin;skin squamous cell carcinoma;small molecule inhibitor;Squamous cell carcinoma;Stimulator of Interferon Genes;Testing;Time;TLR4 gene;TP53 gene;Training;tumor;tumor progression;Tumor Suppressor Proteins;tumorigenesis;Universities;wound;wound healing

PROJECT_TITLE: HMGB1 in EB-Associated Squamous Cell Carcinoma


NIH_SPENDING_CATS: Genetics

ORG_CITY: AUSTIN

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

PHR: The proposed research will provide fundamental knowledge about the coordination of organism-wide growth during development and the functional role of nucleolus, which is the site of ribosome assembly. Our studies will provide concrete leads towards defining and approaching disease conditions associated with ribosome assembly and translational dysfunction.

PI_NAMEs: SARINAY CENIK, ELIF  (contact)

PROGRAM_OFFICER_NAME: CZAPLINSKI, KEVIN

PROJECT_TERMS: Architecture;Biogenesis;Caenorhabditis elegans;Cell Nucleolus;Cell Physiology;Cells;Chromosomes;Complex;Development;Disease;Embryo;Epigenetic Process;Functional disorder;Gene Expression;Genetic Screening;Genome;Growth;Investigation;Knowledge;Light;Mission;Null Lymphocytes;Organism;Pathway interactions;programs;Research;Ribosomal DNA;Ribosomal Proteins;Ribosomes;Role;Site;Structure;System;Tissues

PROJECT_TITLE: Role of Nucleolus and Ribosome Biogenesis in Coordinating Organism-wide Growth

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Cancer;Clinical Research;Immunotherapy

ORG_CITY: ATLANTA

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: GEORGIA INSTITUTE OF TECHNOLOGY

ORG_STATE: GA

PHR: PROJECT NARRATIVE This project investigates the mechanical regulation of binding, signaling, and function of the molecule Programmed cell death 1 (PD-1) in relation to T cell responses to melanoma. Results from this project will advance our understanding of PD-1 mechanobiology and improve cancer immunotherapy by targeting the mechanoregulation of PD-1.

PI_NAMEs: ZHU, CHENG  (contact)

PROGRAM_OFFICER_NAME: JOHNSON, ERIC MICHAEL

PROJECT_TERMS: acute infection;adaptive immunity;Adoptive Cell Transfers;Amino Acids;Antigens;Binding;cancer immunotherapy;Cancer Vaccines;CD28 gene;CD4 Antigens;CD8 receptor;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Differentiation process;cell killing;Cell Physiology;Cells;cellular imaging;chemokine receptor;Chronic;Communicable Diseases;Complex;Coupled;Cytokine Receptors;Cytotoxic T-Lymphocytes;Data;Devices;Discrimination;Disease;Dissociation;DNA;Effector Cell;Engineering;exhaustion;Foundations;Generations;Goals;gp100 Antigen;Human;Image;Immunologist;Immunooncology;Immunotherapy;improved;in silico;In Situ;In Vitro;in vivo;insight;Investigation;Kinetics;Ligands;Major Histocompatibility Complex;Malignant Neoplasms;Mechanics;Mediating;Melanoma;Memory;Methods;Microfluidics;Modeling;Molecular;Molecular Conformation;molecular dynamics;mouse model;multidisciplinary;Mus;Mutate;novel strategies;Oncology;Peptide Receptor;Peptides;physical science;programmed cell death ligand 1;programmed cell death protein 1;receptor;Receptor Signaling;Regulation;Reporting;response;Signal Transduction;single molecule;Solid;stem;stem-like cell;stemness;Structure;synergism;T cell differentiation;T cell response;T cell therapy;T memory cell;T-Cell Activation;T-Cell Receptor;T-Lymphocyte;T-Lymphocyte Subsets;Testing;Therapeutic;Thinking;tool;tumor;Tumor Immunity;Vaccination;Vaccine Therapy;Virus Diseases

PROJECT_TITLE: Exploiting the Mechanobiology of PD-1 for Cancer Immunotherapy


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: IRVINE

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: PROJECT NARRATIVE Inflammation plays both protective and damaging roles in Alzheimer's disease (AD), so to identify a long lasting and effective treatment, it is critical that we better understand the underlying processes. Our studies implicate a cytokine called interleukin-18 (IL-18) as a factor that accelerates AD pathology. Here we propose to uncover the mechanisms by which this cytokine alters basic cell biological functions and how these changes affect AD.

PI_NAMEs: LAFERLA, FRANK M (contact)

PROGRAM_OFFICER_NAME: LI, TONG

PROJECT_TERMS: Acceleration;Acute;Affect;Alzheimer like pathology;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease pathology;Amyloid beta-Protein;Animal Model;Anti-Inflammatory Agents;anxious;Automobile Driving;Behavior;Binding;Biochemical;Biological Process;Brain;Cell Culture Techniques;Cells;Cerebrum;Chronic;Clinic;Cues;cytokine;Dependovirus;desensitization;Development;Disease;effective therapy;Failure;gain of function;Genetic;Homeostasis;Human;hyperphosphorylated tau;IL18 gene;immune function;Immune response;Impaired cognition;Impairment;In Vitro;in vivo;Inflammation;Inflammatory;Inflammatory Response;insight;Interleukin-1 Receptors;interleukin-18 binding protein;interleukin-18 receptor;late endosome;Learning;Link;Long-Term Potentiation;loss of function;Maps;MAPT gene;Mediating;Memory;Methods;Microglia;Microtubules;Molecular;Molecular Target;mouse model;Mus;Nature;Neurofibrillary Tangles;Neurons;neurotoxic;novel;novel strategies;novel therapeutics;Outcome;Pathologic;Pathology;Pathway interactions;pharmacologic;Physiological;Play;pre-clinical;preservation;prevent;Process;Production;Protein Kinase;Protein phosphatase;Proteins;proteomic signature;Proteomics;receptor;Resistance;Resolution;response;restoration;Role;Signal Induction;Signal Transduction;Sum;Synapses;tau dysfunction;tau Proteins;tau-1;Tauopathies;Testing;Therapeutic;therapeutic candidate;TOLLIP gene;tool;trafficking;Translating;Treatment Efficacy;Up-Regulation;Validation

PROJECT_TITLE: Deciphering the role of interleukin-18 as a driver of tau pathology in Alzheimer's disease


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Physical Rehabilitation;Rehabilitation

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Current vestibular rehabilitation only addresses impairments and does not include targets that contribute to low activity and participation in people with vestibulopathy. It is unclear whether reductions in vestibular impairment translate to improvement in activity and participation and, if so, through what mechanisms or predisposing factors. This project will use input from stakeholders (patients with vestibulopathy and the physical therapists who provide vestibular rehabilitation care) to iteratively refine an enhanced vestibular rehabilitation that aims to improve activity and participation and augment current vestibular rehabilitation.

PI_NAMEs: KLATT, BROOKE  (contact)

PROJECT_TERMS: Address;Adult;Age;Behavioral;behavioral clinical trial;Blurred vision;career development;Caring;Case Series;Charities;Chronic disability;Clinical;Clinical Trials;Clinical Trials Design;Cognition;Cognitive;cohort;comorbidity;Complex;coping;Coping Skills;Crowding;Data Analyses;design;Deterioration;Development Plans;disability;Disabling;Dizziness;Doctor of Philosophy;effective intervention;Effectiveness of Interventions;efficacy evaluation;efficacy testing;Environment;Environmental Risk Factor;Epidemiologic Methods;Equilibrium;Equipment and supply inventories;experience;fall risk;Feedback;Foundations;Fright;Future;Gait;gaze;Impaired cognition;Impairment;improved;Incidence;Individual;insight;instrument;Intervention;intervention refinement;Intervention Trial;Interview;K-Series Research Career Programs;late life;longitudinal analysis;Measures;medical attention;Mental Health;Methodology;Moods;Motion;multidisciplinary;multimodality;Nausea;novel;Outcome;Patients;Perception;Persons;physical therapist;Population;Positioning Attribute;Predisposing Factor;Protocols documentation;Provider;Quality of life;Recovery;rehabilitation science;Rehabilitation therapy;rehabilitative care;remediation;Reporting;Research;Research Priority;Science;Scientist;Sensorimotor functions;Series;skills;Structure;Testing;Theoretical model;therapy development;Training;Translating;United States;Vestibular Diseases;Vestibular dysfunction;vestibular system;Visual;Vulnerable Populations

PROJECT_TITLE: Activity and Participation in Vestibulopathy

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Child Abuse and Neglect Research;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Networking and Information Technology R&D (NITRD);Pediatric;Primary Health Care;Social Determinants of Health;Telehealth;Violence Research;Youth Violence

PHR: Project Narrative The COVID-19 pandemic shredded safety nets in the child welfare system; it made evident to providers, administrators, and policymakers how fragile our child protective system is. In-home services, a critical source of support for families, were quickly replaced with telehealth services. This study addresses the effectiveness and acceptability of delivery of an evidence-based home-visiting program to families in the child protective system with children under the age of 18 months at enrollment using telehealth methodology.

PI_NAMEs: OXFORD, MONICA L (contact)

PROGRAM_OFFICER_NAME: ESPOSITO, LAYLA E

PROJECT_TERMS: 2019-nCoV;Address;Adherence;Administrator;Age;arm;Attention;care systems;Caregivers;Caring;Child;Child Care;child protective service;Child Rearing;Child Welfare;Communities;Control Groups;Cost Analysis;cost effective;cost effectiveness;Cost-Benefit Analysis;COVID-19;COVID-19 pandemic;Data;design;Development;distraction;dosage;Drops;Economics;Effectiveness;effectiveness evaluation;effectiveness testing;Eligibility Determination;Emotional;Enrollment;evidence base;Evidence based program;externalizing behavior;Failure;Family;family support;foster care;Foundations;Funding;Health Personnel;Health Services;Health Services Accessibility;Home;Home visitation;Household;improved;innovation;Interruption;Investigation;Knowledge;Learning;maltreatment;Measures;member;Mental Health;Methodology;Modeling;Monitor;Natural experiment;Noise;Occupations;online delivery;Outcome;pandemic disease;Parent-Child Relations;Parents;Persons;Policy Maker;prevention service;Procedures;programs;Protocols documentation;Provider;provider adherence;randomized controlled design;Randomized, Controlled Trials;Reporting;response;Risk;safety net;Sampling;satisfaction;school closure;Schools;service delivery;Service delivery model;service providers;service utilization;Services;social;Social Change;social service provider;Source;System;Technology;telehealth;Time;treatment as usual;United States;Universities;Washington;welfare;wireless fidelity;Work;Youth

PROJECT_TITLE: Delivering Evidence-Based Parenting Services to Families in Child Welfare Using Telehealth

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


NIH_SPENDING_CATS: Neurosciences

ORG_DEPT: PHARMACOLOGY

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: The neuroscience training mission of BU resonates with a shared belief that major discoveries relevant to public health will come from innovative thinking and an interdisciplinary community of faculty and students. An essential feature is a set of core courses that are taken by all students in the Graduate Program for Neuroscience, which is aimed at developing a community of thinkers, who move through their training together, building relationships that cross inter- departmental and inter-campus barriers, and foster cross disciplinary collaborations. Every effort is expended to provide an individually tailored mentorship and educational program for each student with an emphasis on rigor and reproducibility that builds upon their unique strengths and interests, while also recognizing areas that need enrichment via faculty guidance and curriculum choice.

PI_NAMEs: RUSSEK, SHELLEY J (contact)

PROGRAM_OFFICER_NAME: WEIGAND, LETITIA ALEXIS

PROJECT_TERMS: Neurosciences;programs

PROJECT_TITLE: Graduate Program for Neuroscience


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: FARMINGTON

ORG_DEPT: ORTHOPEDICS

ORG_NAME: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT

PHR: Project Narrative: Polysaccharides such as cellulose hold great promise for tissue repair and regeneration, but overcoming barriers to their full clinical potential will require developing and testing new innovative composites. Our proposal aims to address issues of adaptability, strength, and degradability by designing and evaluating a cellulose-based putty- enabling platform with tunable degradation, broad bioactive factor release properties, and appropriate mechanical strength for bone healing. This work is expected to enhance our understanding of cellulose and its utility as a biomaterial for tissue repair by evaluating its effects on cell behaviors and bone regeneration.

PI_NAMEs: KUMBAR, SANGAMESH GURAPPA (contact)

PROGRAM_OFFICER_NAME: FEHR, TUBA HALISE

PROJECT_TERMS: 3-Dimensional;Acetates;Address;Biocompatible Materials;Biological Assay;biomaterial compatibility;bone;Bone Density;bone engineering;bone healing;Bone Matrix;Bone Regeneration;bone repair;bone strength;Bone Tissue;Bone Transplantation;calcium phosphate;Calvaria;cell behavior;Cell Culture Techniques;Cellulose;Cephalic;Ceramics;clay;Clinical;comparison control;Complement;Complex;cortical bone;Coupled;craniofacial;Defect;demineralization;design;Development;Diffusion;Drug or chemical Tissue Distribution;dynamic system;Economic Burden;efficacy testing;Enabling Factors;Ensure;Equilibrium;Excipients;Extracellular Matrix;FDA approved;flat bone;flexibility;Formulation;Fracture;Future;Generations;Growth;Growth Factor;halloysite;Hydrogels;Impaired healing;implantable device;implantation;In Vitro;in vivo;innovation;Knowledge;long bone;Mechanics;Mesenchymal Stem Cells;Modeling;Molds;mouse model;nano;Nanotubes;Natural regeneration;novel;Oryctolagus cuniculus;Osteoblasts;Osteoclasts;Osteogenesis;Pharmaceutical Preparations;phthalates;Physiologic pulse;Physiological;Plants;Polymers;Polymethyl Methacrylate;Polysaccharides;Porosity;Property;Proteins;release factor;repaired;Research;scaffold;Shapes;Site;Solubility;stem cell delivery;stem cell expansion;Sterilization;subcutaneous;System;Technology;Temperature;Testing;three dimensional structure;Time;Time Factors;tissue regeneration;tissue repair;Tissues;ulna;Variant;Vascularization;Vertebral column;Weight-Bearing state;Work

PROJECT_TITLE: Polysaccharide putty formulations for tissue regeneration

STUDY_SECTION: MTE

STUDY_SECTION_NAME: Musculoskeletal Tissue Engineering Study Section[MTE]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Project Narrative Alterations in the distribution of cellular cholesterol in the brain has been linked to a host of chronic neurodegenerative disorders. This study will investigate the mechanisms through which lysosomal cholesterol transport can modify the distribution and activity of ion channels to shape neuronal function. The results from the proposed work could inform novel therapeutic strategies to treat neuropathophysiological disorders.

PI_NAMEs: DICKSON, EAMONN JAMES (contact)

PROGRAM_OFFICER_NAME: NIE, ZHONGZHEN

PROJECT_TERMS: Alzheimer's Disease;Animal Behavior;Attention;Autophagocytosis;Award;behavior test;Brain;Brain Mapping;Brain region;Calcium;Cell membrane;Cellular Membrane;Cholesterol;Cholesterol Homeostasis;cholesterol transporters;Chronic;Communication;cytotoxic;Dementia;Disease;Electrophysiology (science);Elements;Endoplasmic Reticulum;Gatekeeping;Genetic Transcription;Golgi Apparatus;Homeostasis;Instruction;Ion Channel;Knowledge;Lead;Link;loss of function mutation;Lumen of the Lysosome;lysosome membrane;Lysosomes;Membrane;Metabolism;Mitochondria;mitochondrial membrane;Modeling;Molecular;mouse model;Nerve Degeneration;Neurodegenerative Disorders;neuronal excitability;Neurons;neuropathology;neurotoxic;novel;novel therapeutic intervention;Nuclear Pore Complex;Optics;Parkinson Disease;progressive neurodegeneration;Reporting;Seizures;Shapes;Signal Transduction;Site;superresolution imaging;Symptoms;System;Testing;Toxic effect;Work

PROJECT_TITLE: Lysosomal control of plasma membrane -endoplasmic reticulum membrane contacts regulates neuronal excitability


ED_INST_TYPE: SCH OF BUSINESS/PUBLIC ADMIN

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Social Determinants of Health

ORG_CITY: CHAMPAIGN

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

PHR: Project Narrative We propose to provide new evidence on the causal relationship between income and health and the mechanisms underlying this relationship by evaluating a large-scale unconditional cash transfer program that randomly assigns participants to a treatment group that receives $1,000 per month for 3 years or a control group that receives $50 per month. To estimate the causal effect of the additional income on health, we will examine treatment/control differences in physical and mental health outcomes and intermediate outcomes, such as physical activity, nutrition, neighborhood characteristics, and medical care access and utilization, that could affect longer-term health outcomes. Our study will provide new, timely, and policy-relevant evidence on the health implications of income support and the causal mechanisms underlying the relationship between income and health.

PI_NAMEs: BARTIK, ALEXANDER WICKMAN (contact)

PROGRAM_OFFICER_NAME: JEKIELEK, SUSAN

PROJECT_TERMS: Adult;Affect;Aftercare;Anxiety;Automobile Driving;Behavior;Biological Markers;Blood;Blood Glucose;Blood Pressure;C-reactive protein;Caring;Characteristics;Cholesterol;Cities;Commuting;Consent;Control Groups;Country;COVID-19;COVID-19 pandemic;diabetes risk;diaries;Disease;Economics;Education;Eligibility Determination;Emergency department visit;Environment;Environmental Risk Factor;Evaluation;Exercise;Food;food security;Glycosylated Hemoglobin;Health;Health behavior;Health Benefit;health knowledge;Health Services Accessibility;Healthcare;Height;Hospitalization;Housing;improved;Incidence;Income;Individual;Intervention;Life;Link;Longterm Follow-up;Low income;Measures;Medical;Mental Depression;Mental Health;mortality;National Health Interview Survey;Nature;Neighborhoods;Nonprofit Organizations;nutrition;Nutritional;Outcome;Outcome Assessment;Outcome Measure;Participant;payment;Personal Satisfaction;Persons;Physical activity;physical conditioning;Policies;Policy Maker;population health;poverty alleviation;Preventive care;professional atmosphere;programs;Proxy;Public Health;Random Allocation;Randomized;Randomized, Controlled Trials;Records;Reporting;Research;Research Support;Role;Sampling;Services;Sleep;sleep quality;Social Sciences;Spottings;Stress;substance use;Surveys;Time;tool;Training;treatment group;Variant;Weight;Work

PROJECT_TITLE: Experimental evidence on the relationship between income and health

STUDY_SECTION: SSPA

STUDY_SECTION_NAME: Social Sciences and Population Studies A Study Section[SSPA]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Women's Health Research

PHR: PROJECT NARRATIVE The proposed studies aim to determine the role of the Mucin-4 cell-surface glycoprotein in platelet-tumor cell interactions in breast cancer metastasis. Successful completion of these studies will reveal a novel method of platelet-tumor cell crosstalk which enhances survival of metastasizing tumor cells. Characterization of this relationship will advance understanding of metastasis and reveal a novel target for metastatic intervention.

PI_NAMEs: FREE, SAVANNAH R (contact)

PROGRAM_OFFICER_NAME: ODEH, HANA M

PROJECT_TERMS: Affect;Anoikis;Apical;Apoptosis;Automobile Driving;Behavior;Binding;Biochemical;Biological Assay;Blood Circulation;Blood Platelets;Breast;Breast Cancer Cell;Breast Cancer cell line;breast cancer metastasis;Breast Cancer Treatment;cell behavior;Cell Communication;Cell Survival;Cells;Cessation of life;Chemicals;Circulation;Development;Disease;Distant Metastasis;Epidermal Growth Factor;Epithelial Cells;epithelial to mesenchymal transition;ERBB2 gene;Face;Feedback;Gene Expression;Genes;Genetic Transcription;Glycoproteins;glycosylation;Goals;Immune;improved;In Vitro;in vivo;in vivo Model;Intervention;Link;Lubricants;Maintenance;Malignant Breast Neoplasm;Mediating;Mediator;Membrane Glycoproteins;Metastatic breast cancer;Methods;Modeling;Molecular;Morphology;mouse model;Mucins;Neoplasm Circulating Cells;Neoplasm Metastasis;neoplastic cell;new therapeutic target;novel;Outcome;P-Selectin;Patient-Focused Outcomes;Patients;Platelet Activation;Platelet aggregation;Play;Prevention;Primary Neoplasm;Proteins;Publishing;receptor;recruit;Regulation;Research;Resistance;Role;Signal Transduction;standard of care;success;Surface;Survival Rate;Tail;Techniques;Testing;Therapeutic Intervention;Transcript;Transforming Growth Factor beta;tumor;Tumor Promotion;tumor xenograft;Up-Regulation;Veins

PROJECT_TITLE: The TGF-Beta/MUC4 Signaling Axis in Circulating Tumor Cells of Metastatic Breast Cancer


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases;Microbiome

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Staphylococcus aureus is a Gram-positive opportunistic pathogen that causes the majority of soft skin and tissue infections (SSTIs). This work investigates human skin metabolite contribution to S. aureus skin colonization using new, accessible models of the human skin surface environment.

PI_NAMEs: COSTA, FLAVIA GISELA (contact)

PROGRAM_OFFICER_NAME: HUNTLEY, CLAYTON C

PROJECT_TERMS: Acidity;Address;Adult;Amino Acids;Ammonia;Animal Model;Anterior nares;Antibiotic Resistance;Arginine;Atopic Dermatitis;Biochemical;Carbon;Chelating Agents;Clinical;Communities;Complement;Data Set;Deamination;Defect;Development;Eccrine Glands;Environment;Epidemic;Epidemiology;experimental study;filaggrin;Foundations;Future;Gene Expression Regulation;Genes;Genetic;Genetic Transcription;Genus staphylococcus;Growth;Health;Hospitals;Human;Hydrolysis;In Vitro;in vitro Model;in vitro testing;in vivo;Infection;Infection prevention;infection risk;Infectious Skin Diseases;inhibitor;interest;Ions;keratinocyte;keratinocyte differentiation;Laboratories;Measures;Metabolic;Metabolism;methicillin resistant Staphylococcus aureus;Methodology;microorganism;Modeling;mouse model;Mus;mutant;Natural Immunity;Nickel;Nitrogen;novel strategies;opportunistic pathogen;Organ;Other Genetics;Outcome;pathogen;Pathway interactions;Patients;pH Homeostasis;Physiology;Population;Publishing;Recipe;Reporter;Research;response;Risk;Role;Sepsis;Skin;Skin colonization;skin microbiota;skin organogenesis;Soft Tissue Infections;Source;soy;Staphylococcus aureus;Staphylococcus aureus infection;Structure;Substrate Specificity;Surface;Sweat Glands;Systemic infection;Testing;Therapeutic;therapeutic development;Therapeutic Intervention;therapeutic target;Tissue Model;Tissues;transcriptome sequencing;transmission process;Ultraviolet Rays;Up-Regulation;Urea;urea transporter;Urease;Urocanic Acid;Virulent;Western Blotting;Work

PROJECT_TITLE: Metabolic determinants of Staphylococcus aureus skin colonization


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Genetics;Human Genome

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: Project Narrative Genomic technologies promise to transform our understandings of human biology and history and offer unprecedented power to influence the health of individuals and generations. Such knowledge and power imply immense responsibility to use them in ways that promote social and ethical values in the service of the public’s health. This research training program aims to nurture a diverse cadre of interdisciplinary scholars prepared to engage critically and respectfully with, and advance our knowledge and understanding of, the profound ethical, legal and social (ELSI) challenges that genomic technologies raise.

PI_NAMEs: JOFFE, STEVEN  (contact)

PROGRAM_OFFICER_NAME: STERLING, RENE

PROJECT_TERMS: ethical, legal, and social implication;Genetic;Genomics;post-doctoral training;Training Programs

PROJECT_TITLE: Penn Postdoctoral Training Program in the Ethical, Legal and Social Implications of Genetics and Genomics


NIH_SPENDING_CATS: Digestive Diseases;Human Fetal Tissue;Infectious Diseases;Pediatric;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: PALO ALTO

ORG_NAME: PALO ALTO VETERANS INSTIT FOR RESEARCH

PHR: PROJECT NARRATIVE Balanced immunity in the gastrointestinal tract is essential to health, and imbalance contributes to inflammatory bowel disease (IBD), cancer, allergic, and metabolic disorders. Our studies identify new mechanisms and cells and their roles in establishing the gut immune system to protect newborn babies against viruses and bacterial infections, and to prevent inflammatory bowel disease, allergic and infectious diseases in adults. The results will improve our understanding of a healthy mucosal immune system, and could provoke novel preventative, therapeutic treatment strategies or cures for these infectious and inflammatory diseases.

PI_NAMEs: BUTCHER, EUGENE C (contact)

PROGRAM_OFFICER_NAME: HUDSPETH, KELLY

PROJECT_TERMS: Address;Adhesions;Adult;Allergic;Allergic Disease;analog;assault;Autoimmune Diseases;Bacterial Infections;Birth;Blood;CCL25 gene;CCR9 gene;Cell Maturation;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Chemotactic Factors;Coculture Techniques;Colon;Communicable Diseases;cytokine;Cytometry;Data;Defense Mechanisms;Development;Disease;Embryo;Enteral;Enterobacteriaceae;Environment;Epithelial Cells;Epithelium;fetal;fetus cell;Flow Cytometry;fMet-Leu-Phe receptor;food antigen;Gastrointestinal tract structure;Gene Expression Profile;Genes;Genetic Models;Goals;GPR15 gene;Health;high dimensionality;Home;Homeostasis;Homing;Human;Immune;Immune system;Immune System Diseases;Immunity;immunoregulation;improved;in vivo;Inflammatory;Inflammatory Bowel Diseases;innovation;insight;intestinal epithelium;intestinal maturation;Intestines;intraepithelial;Life;Lymphocyte;lymphocyte trafficking;Malignant Neoplasms;Mediating;Metabolic Diseases;microbial;Modeling;Mucosal Immune System;Mucosal Immunity;Mucous Membrane;Mus;Mutant Strains Mice;Natural regeneration;Nature;Neonatal;neonatal immunity;Newborn Infant;novel;novel diagnostics;Organoids;Paneth Cells;pathogen;Pathway interactions;Perinatal;perinatal period;Population;postnatal period;prenatal;Preparation;prevent;Prevention strategy;progenitor;programs;Protocols documentation;receptor;reconstitution;recruit;Resistance;response;Role;Rotavirus;Salmonella;self-renewal;single-cell RNA sequencing;Skin;Small Intestines;Somatostatin;stem cell differentiation;stemness;T-Lymphocyte;T-Lymphocyte Subsets;Testing;Therapeutic;Thymus Gland;Time;tool;trafficking;treatment strategy;Viral;Virus Diseases

PROJECT_TITLE: Intestinal Lymphocyte Trafficking


NIH_SPENDING_CATS: Bioengineering

ORG_DEPT: PHYSICS

ORG_NAME: CARNEGIE-MELLON UNIVERSITY

PHR: Project Narrative The computational model for bacterial growth and antibiotic response will identify the feedback pathways for antibiotic resistance. This will have direct influence on the design strategies for antibacterial therapies and protocols. Our study on cell state transitions in response to anoxia and metabolic arrest will identify the molecular mechanisms for inducing states of dormancy, limits to reversibility of dormant states and their preservation for cellular transplants.

PI_NAMEs: BANERJEE, SHILADITYA  (contact)

PROGRAM_OFFICER_NAME: BLATCH, SYDELLA ANNE

PROJECT_TERMS: Anoxia;Anti-Bacterial Agents;Antibiotic Resistance;Antibiotics;Bacterial Model;Behavior;Biochemical;Biochemical Pathway;biological adaptation to stress;biological systems;biophysical model;Biophysical Process;Biophysics;Calibration;cell behavior;Cell model;Cell Shape;Cell Transplantation;Cells;Cellular Stress;Complex;Computer Models;computerized tools;Cues;Data;Data Analyses;deprivation;design;Development;driving force;Embryo;environmental stressor;Feedback;Goals;Growth;interdisciplinary approach;Metabolic;Modeling;Molecular;Morphogenesis;Nematoda;Nutrient;Pathway interactions;physical property;Physics;Physiological;predictive modeling;preservation;Process;Proliferating;Property;Protocols documentation;Research;response;Role;simulation;Stress;System;Systems Biology;Testing;theories;tool

PROJECT_TITLE: Biophysical models and mechanisms for cellular adaptation to environmental stress

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-R(55)R]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics;Hearing Loss;Human Genome;Neurosciences;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: PROJECT NARRATIVE Sound-sensing cells in the human inner ear are vulnerable to damage, resulting in permanent hearing loss. There is currently no treatment option to biologically cure profound hearing loss. This study will establish a novel human in vitro platform with which to study the cause/progression of hearing loss and identify/test promising therapeutic approaches to treat hearing loss.

PI_NAMEs: HASHINO, ERI  (contact)

PROGRAM_OFFICER_NAME: FREEMAN, NANCY

PROJECT_TERMS: Acceleration;Affect;Age;Animal Model;Auditory;Auditory system;Biological;Biomimetics;Biopsy;Brain Stem;Cell Aggregation;Cell Differentiation process;Cell Maturation;Cell Therapy;cell type;Cells;Central Nervous System;Chemicals;Clustered Regularly Interspaced Short Palindromic Repeats;Cochlea;cochlear development;CRISPR screen;Custom;deaf;deafness;Derivation procedure;Development;Disease;Dorsal;Electron Microscopy;Electrophysiology (science);Engineering;Epithelium;Gelatin;Generations;Genes;Genetic Programming;Genetic study;Genome engineering;Hair Cells;Hearing;hearing impairment;hearing restoration;hindbrain;Human;human embryonic stem cell;human model;human pluripotent stem cell;Hydrogels;Immunofluorescence Immunologic;improved;In Vitro;in vitro Model;inducible gene expression;inner ear development;Laboratories;Labyrinth;mechanical properties;Mediating;Microfluidics;microphysiology system;Midbrain structure;Modification;Morbidity - disease rate;Morphology;Mus;neural;neural circuit;neural network;Neurons;next generation;novel;Organ;Organoids;Outcome Study;Outer Hair Cells;patch clamp;Pathologic;Pattern;Peripheral;Peripheral Nervous System;permanent hearing loss;Population;Property;Protocols documentation;Publishing;Reporter;Research;sensor;Sensorineural Hearing Loss;Sensory;Sensory Hair;Signaling Molecule;single-cell RNA sequencing;small molecule;sound;spatiotemporal;Specificity;stem cell technology;System;Systems Development;Technology;Testing;Therapeutic;three dimensional cell culture;Thyroid Hormones;Tissue Engineering;Tissues;tool;transcription factor;Vestibular Hair Cells;vestibular system;Zinc Fingers

PROJECT_TITLE: Engineering High-Fidelity Human Cochlear Organoids

STUDY_SECTION: BNVT

STUDY_SECTION_NAME: Bioengineering of Neuroscience, Vision and Low Vision Technologies Study Section[BNVT]


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Genetics;Hepatitis;Liver Disease;Precision Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

PHR: Project Narrative Non-alcoholic fatty liver disease (NAFLD) is a major health crisis with no approved therapeutics and many failures in the clinic. A vascularized patient-derived liver acinus microphysiology system (vLAMPS) is an innovative precision medicine platform for optimizing clinical trial design for NAFLD. We will test the response of induced pluripotent stem cell-derived liver cells from NAFLD patients in vLAMPS with either the high-risk variant PNPLA3 I148M or the wild-type to the drugs (pioglitozone, Obeticholic acid and two controls).

PI_NAMEs: BEHARI, JAIDEEP ;SOTO-GUTIERREZ, ALEJANDRO ;TAYLOR, D. LANSING (contact)

PROGRAM_OFFICER_NAME: HARGROVE, PASSLEY R

PROJECT_TERMS: Acids;Adipose tissue;Adult;Agonist;Animal Model;Animals;Autologous;Biopsy;Blood Vessels;Cell Culture Techniques;Cell model;cell type;Cells;Chronic Disease;chronic liver disease;Cirrhosis;Clinic;Clinical;Clinical Data;Clinical Trials;Clinical Trials Design;clinically relevant;cohort;Combination Drug Therapy;comorbidity;Complex;Data;Development;Diabetes Mellitus;Disease;disease model;disease phenotype;Disease Progression;drug candidate;Drug Combinations;Drug Controls;drug development;drug repurposing;drug testing;efficacious treatment;Endothelial Cells;Enrollment;Epidemic;Exhibits;Experimental Models;Failure;Fatty Liver;FDA approved;Fibrosis;Future;Genetic;Genetic Polymorphism;Genetic Variation;Genotype;Goals;Health;hepatic acinus structure;Hepatocyte;Heterogeneity;High Prevalence;high risk;Histologic;Human;human induced pluripotent stem cells;Individual;individual patient;induced pluripotent stem cell;Inflammation;innovation;Insulin Resistance;Investigational Drugs;Knock-in;Kupffer Cells;lifestyle factors;Liver;Liver Failure;Liver Fibrosis;liver function;Liver Stem Cell;Lobular;Measurement;Metabolic;metabolic-associated fatty liver disease;Metformin;microphysiology system;Modeling;Molecular;mouse model;non-alcoholic fatty liver disease;Non-Insulin-Dependent Diabetes Mellitus;nonalcoholic steatohepatitis;Obesity;Outcome;Oxygen;Pathway interactions;patient derived induced pluripotent stem cells;Patients;Pharmaceutical Preparations;Pharmacodynamics;pharmacologic;Pharmacotherapy;Phase;Phenotype;Pioglitazone;Population;PPAR gamma;pre-clinical;precision medicine;Preclinical Testing;Prevalence;Primary carcinoma of the liver cells;Process;progression risk;Progressive Disease;Public Health;Reproducibility;response;Risk;risk variant;Source;species difference;stellate cell;Subgroup;Testing;Therapeutic;Therapeutic Intervention;transcriptome sequencing;Treatment Efficacy;Ursodeoxycholic Acid;Variant;Vascularization

PROJECT_TITLE: A vascularized patient-derived iPSC liver acinus microphysiology system as an innovative precision medicine platform for optimizing clinical trial design for nonalcoholic fatty liver disease


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Drug Abuse (NIDA only);Emerging Infectious Diseases;Fentanyl Misuse and Addiction;HIV/AIDS;Harm Reduction for Substance Misuse;Health Services;Infectious Diseases;Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Prevention;Sexually Transmitted Infections;Social Determinants of Health;Substance Misuse;Substance Misuse Prevention

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Project Narrative The proposed study aims to develop, implement and evaluate the effectiveness and cost-effectiveness of a mobile, integrated PrEP intervention that delivers on-site PrEP and peer navigation to increase the engagement of people who inject drugs in the PrEP continuum. The intervention will be delivered to the target population through a stepped wedge cluster randomized trial and outcomes will be evaluated through a prospective cohort and qualitative interviews. The study will lay the foundation for the implementation of initiatives targeting these populations in other locales to simultaneously address the pressing public health challenges conferred by HIV, COVID-19 and opioid use.

PI_NAMEs: SHERMAN, SUSAN G. (contact)

PROGRAM_OFFICER_NAME: JENKINS, RICHARD A

PROJECT_TERMS: Address;AIDS prevention;Awareness;Baltimore;Behavioral Model;care systems;Caring;Chemicals;Cities;Client;Cluster randomized trial;Communities;comorbidity;condoms;Continuity of Patient Care;cost effectiveness;Cost Effectiveness Analysis;Counseling;Country;COVID-19;COVID-19 impact;COVID-19 pandemic;design;Disease Outbreaks;drug market;Drug usage;Drug user;effectiveness evaluation;Effectiveness of Interventions;Environment;Epidemic;Exhibits;experience;Fentanyl;fentanyl test;Focus Groups;Foundations;Frequencies;General Population;health care service;Healthcare;Heroin;high risk;HIV;HIV Infections;HIV risk;HIV/STD;housing instability;Human immunodeficiency virus test;Illicit Drugs;implementation science;improved;Incidence;incremental cost-effectiveness;Indiana;Injecting drug user;Injections;innovation;interest;Intervention;Interview;Locales;Maintenance;Massachusetts;Measures;mHealth;Modeling;Morbidity - disease rate;mortality;Naloxone;naloxone dispensing;Needle Sharing;Needle-Exchange Programs;novel;Nurse Practitioners;opioid epidemic;opioid treatment program;opioid use;Outcome;outreach services;Overdose;overdose death;overdose prevention;peer;peer support;Penetration;Pharmaceutical Preparations;Pharmacotherapy;Population;Populations at Risk;pre-exposure prophylaxis;prevent;Prevention;prevention service;preventive intervention;primary outcome;programs;Prospective cohort;Provider;Public Health;recruit;Reporting;Research;response;Risk;Risk Behaviors;Risk Reduction;scale up;secondary outcome;Service delivery model;service engagement;Services;Site;standard of care;substance use;Target Populations;test strip;Testing;therapy design;Time;tool;treatment services;trend;two way texting;United States National Institutes of Health;Unsafe Sex;uptake;West Virginia

PROJECT_TITLE: Impact of a novel HIV peer navigationand overdose prevention intervention on engagement in the HIV prevention and treatment cascade.


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Clinical Research;Digestive Diseases;Inflammatory Bowel Disease;Liver Disease;Lymphatic Research

ORG_CITY: SAINT LOUIS

ORG_DEPT: PATHOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE The molecular and cellular cargo that escapes the intestinal mucosa has the potential to spread inflammatory signals or infections, but how the intestine is poised to sort such cargo between blood and lymph to minimize negative host outcomes in unknown. This application has assembled a multi-disciplinary, multi-institutional team that incorporates state-of-the-art multi-omics, intravital imaging, surgical prowess, and unique experimental models to define the molecular cargo traversing lymph versus venous blood from different regions of the gut and determine how these drainage sites are equipped to combat spread of inflammation. The resources, skills, and approaches of this group may be of broad interest to the mucosal immunology community in general, as much of the cargo draining other mucosal surfaces also remains undefined.

PI_NAMEs: RANDOLPH, GWENDALYN J (contact)

PROJECT_TERMS: absorption;Address;Affect;Antibody Therapy;B-Lymphocytes;Behavior;Biological;Biology;Blood;Blood Vessels;Cells;Characteristics;Circulation;Colon;combat;Communities;Crohn's disease of the ileum;Data;Disease;Distal;Drainage procedure;Endothelium;Epithelial Cells;Epithelium;Evaluation;Excision;Experimental Models;Extravasation;Genes;gut microbes;Gut Mucosa;Hepatocyte;High Density Lipoproteins;ileum;Immune;Immunology;Infection;Inflammation;Inflammatory;Inflammatory Bowel Diseases;inhibitor;Institution;interest;intestinal barrier;intestinal epithelium;Intestinal Mucosa;Intestines;intravital imaging;Knowledge;Laboratories;Leukocyte Rolling;Leukocytes;lipidome;lipidomics;Lipids;Lipoprotein (a);Lipoproteins;Liver;Liver diseases;liver injury;Location;Lung;lung injury;Lymph;Lymphatic;lymphatic vessel;Mediating;Mesentery;Microbe;microbial;microbiome;Molecular;monocyte;mouse model;Mucous Membrane;multidisciplinary;multiple omics;Mus;Nature;neutralizing antibody;neutrophil;non-alcoholic;novel;Nutrient;nutrient absorption;Operative Surgical Procedures;organ injury;Outcome;Phagocytes;Phagocytosis;Pharmaceutical Preparations;Plasma Cells;porcine model;Portal vein structure;problem drinker;Production;programs;Proteome;Proteomics;Regulation;Resources;response;Role;Signal Transduction;Site;skills;Small Intestines;Sorting;superior mesenteric vein;Surface;Thoracic Duct;Tissues;TLR4 gene;TNF gene;Vaccination;Validation;Veins;Venous;Villus;White Blood Cell Count procedure;Whole Blood

PROJECT_TITLE: Gut region-specific mechanisms that limit dissemination of microbial signals from the intestine