NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Diabetes;Digestive Diseases;Obesity;Orphan Drug;Rare Diseases

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: The underlying autoimmune mechanisms which result in loss of body fat in patients with acquired generalized lipodystrophies (AGL) and acquired partial lipodystrophies (APL) remain largely unknown. Thus, the main aim of this proposal is to identify additional antigens expressed in body fat tissue, such as recently discovered perilipin-1 (PLIN1), against which patients with AGL and APL develop autoantibodies and to determine their function in adipocyte biology. The other aims are to determine how these autoantibodies cause loss of body fat and insulin resistance and metabolic derangements using the mouse models.

PI_NAMEs: ANDERSON, MARK S;GARG, ABHIMANYU  (contact)

PROGRAM_OFFICER_NAME: BLONDEL, OLIVIER

PROJECT_TERMS: Abdomen;adipocyte biology;Adipocytes;Adipose tissue;Animal Model;antigen detection;Antigens;Autoantibodies;Autoantigens;Autoimmune;Autoimmune Diseases;Autoimmune Process;Autoimmune Responses;Autoimmunity;Biological Assay;Body fat;Body Regions;Cells;Chest;Clinical;cohort;Complement 3;Complement 3 Nephritic Factor;Complement component C4;Data;Development;Diabetes Mellitus;Disease;Dyslipidemias;Etiology;Face;Familial generalized lipodystrophy;Fatty acid glycerol esters;Fatty Liver;Goals;Health;High Prevalence;Human;human model;Immune;Immunoglobulin G;Infiltration;Inflammatory;Infusion procedures;Insulin Resistance;Juvenile Dermatomyositis;Knowledge;Lesion;Lipodystrophy;Lymphocyte;Mediating;Membranoproliferative Glomerulonephritis;Metabolic;Mononuclear;Morbidity - disease rate;mouse model;Mus;Neck;nonalcoholic steatohepatitis;novel;novel therapeutics;Obesity;Panniculitis;Pathogenesis;Pathogenicity;Patients;perilipin;Phage ImmunoPrecipitation Sequencing;Polyglandular Autoimmune Syndrome Type I;Principal Investigator;Production;programs;Proteins;Proteinuria;Proteome;Recording of previous events;Reporting;Role;Serum;subcutaneous;T-Lymphocyte;Techniques;Therapeutic;therapeutic target;Thymus Gland;Tissues;Visceral fat

PROJECT_TITLE: Autoimmune Basis of Acquired Lipodystrophies

STUDY_SECTION: HSDO

STUDY_SECTION_NAME: Human Studies of Diabetes and Obesity Study Section[HSDO]


ADMINISTERING_IC: NS

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Chronic Pain;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy

ORG_CITY: ATLANTA

ORG_COUNTRY: UNITED STATES

ORG_DEPT: NEUROSCIENCES

ORG_FIPS: US

ORG_NAME: GEORGIA STATE UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative The perception of noxious thermal stimuli is often coupled to pain sensation as a protective mechanism, however, aberrant temperature sensation can lead to neuropathic pain (e.g., in peripheral nerve injury; multiple sclerosis; fibromyalgia; stroke; and chemotherapeutic-induced peripheral neuropathy) where patients experience pain due to cold hypersensitivity. By uncovering basic biophysical, cellular, and molecular mechanisms of noxious cold perception, we develop critical insights into neural integration of painful/nociceptive stimuli providing potential routes for understanding and treating neurological disease when this process is disrupted.

PI_NAMEs: COX, DANIEL N (contact);CYMBALYUK, GENNADY S

PROGRAM_OFFICER_NAME: MOHAPATRA, DURGA PRASANNA

PROJECT_TERMS: Acute Pain;Address;Afferent Neurons;allodynia;Automobile Driving;base;Behavior;Behavioral;Behavioral Assay;behavioral response;Biochemical;Biological Models;Biophysical Process;Biophysics;Calcium;Cell Physiology;cellular imaging;Cessation of life;Chemotherapy-induced peripheral neuropathy;Chloride Channels;chronic pain;Code;cold temperature;Complex;Computer Models;computerized tools;Coupled;Cytoskeleton;Detection;Discrimination;Dissection;Drosophila genus;Electrophysiology (science);Esthesia;experience;Fibromyalgia;Functional Imaging;G Protein-Coupled Receptor Signaling;G-Protein-Coupled Receptors;Goals;Health;Hyperalgesia;Hypersensitivity;in vivo;inflammatory pain;insight;Ion Channel;Knowledge;Link;Mechanics;Mechanoreceptors;Membrane;Modality;Modeling;Molecular;multimodality;Multiple Sclerosis;Nervous System Disorder;neural;neurogenetics;Neurologic;Nociception;Nociceptive Stimulus;Organism;Outcomes Research;Output;Pain;pain sensation;painful neuropathy;Patients;Perception;Peripheral;Peripheral nerve injury;Peripheral Nervous System Diseases;Physiological;Play;Population Heterogeneity;Process;Property;receptor;Receptor Signaling;Resolution;response;Role;Route;Sensory;sensory stimulus;Signal Pathway;Signal Transduction;somatosensory;spatiotemporal;Stimulus;Stroke;stroke therapy;Symptoms;System;Temperature;Temperature Sense;Testing;Therapeutic;Tissues;TRP channel;Visual

PROJECT_TITLE: Molecular and Computational Dissection of Cold Nociception

STUDY_SECTION: NPI

STUDY_SECTION_NAME: Neurobiology of Pain and Itch Study Section [NPI]


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biomedical Imaging;Cardiovascular;Clinical Research;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_CITY: PHILADELPHIA

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Of the 1 million people in the US that will develop myocardial infarction (MI) this year 25-50% will be susceptible to sudden death due to malignant arrhythmia over their lifetime. Many strategies are available to mitigate the risk of arrhythmia, and mortality; however, the underlying factors that attenuate individual risks are poorly informed by currently available data. The proposed prospective observational study will define the longitudinal association of reperfusion injury after percutaneous intervention for MI with intra-myocardial fat deposition, negative cardiac remodeling, and malignant arrhythmia.

PI_NAMEs: NAZARIAN, SAMAN  (contact);WITSCHEY, WALTER R.T.

PROGRAM_OFFICER_NAME: SHI, YANG

PROJECT_TERMS: Action Potentials;Acute;Address;Adipose tissue;Affect;Anatomy;animal data;Animals;Apoptosis;Architecture;Arrhythmia;artery occlusion;Attenuated;Binding;Biological Markers;Biometry;Blood flow;Cardiac;Cardiac Electrophysiologic Techniques;cardiac magnetic resonance imaging;Cardiology;Cardiovascular Diseases;cardiovascular health;Cardiovascular system;Cicatrix;Clinical;Clinical Data;cohort;comorbidity;Congestive Heart Failure;Coronary artery;Cox Proportional Hazards Models;Data;Deposition;Development;Dropout;Electrocardiogram;Eligibility Determination;Epidemiology;Evolution;Exhibits;experience;Fatty acid glycerol esters;Fibrosis;follow-up;Funding;Future;Gadolinium;Guidelines;health difference;Health system;Heart failure;heart function;Hemorrhage;high risk;Hospitals;Human;Image;Image Enhancement;Implantable Defibrillators;implantation;Incidence;Individual;Individual Differences;Infarction;Intervention;Iron;Ischemia;life span;Magnetic Resonance;Malignant - descriptor;Maps;Mediating;men;Metaplasia;Modeling;Morbidity - disease rate;mortality;Myocardial;Myocardial Infarction;myocardial injury;Myocardium;National Heart, Lung, and Blood Institute;Observational Study;Participant;Pathologic;Patients;Pennsylvania;personalized therapeutic;Persons;Physics;Population;Predisposition;prevent;prospective;Prospective Studies;Quality of life;Radiology Specialty;rapid diagnosis;Recovery;recruit;Recycling;Reperfusion Injury;Reperfusion Therapy;Research;Research Personnel;Resistance;response;restoration;Risk;risk minimization;risk mitigation;Science;sex;Shock;Strategic vision;Sudden Death;Symptoms;Testing;Time;Tissue Viability;Tissues;treatment response;United States;Universities;Ventricular Tachycardia;Water;Woman

PROJECT_TITLE: LONGITUDINAL ASSOCIATION OF POST-INFARCT LIPOMATOUS METAPLASIA AND MALIGNANT ARRHYTHMIA

STUDY_SECTION: CCHS

STUDY_SECTION_NAME: Clinical Integrative Cardiovascular and Hematological Sciences Study Section[CCHS]


ADMINISTERING_IC: GM

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

ORG_STATE: NY

PHR: The goal of this project is to determine the structures of cytochrome c oxidase (CcO) by using two state-of-the- art technologies: serial femtosecond X-ray crystallography and single particle cryogenic electron microscopy. The outcome derived from this project will yield important knowledge allowing us to comprehend how the oxygen reaction catalyzed by CcO is coupled to proton translocation and how the activity of CcO is regulated by cellular effectors. This research is relevant to the mission of NIH as it will provide a structural framework to guide the development of novel therapeutic strategies targeting related human diseases.

PI_NAMEs: ROUSSEAU, DENIS L. (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TERMS: Active Sites;Adenine Nucleotides;ATP Synthesis Pathway;Automobile Driving;Binding;Binding Sites;Bioenergetics;Biological;Biological Assay;Cattle;Chemicals;Chemistry;Complex;Coupled;Coupling;Cryoelectron Microscopy;Crystallization;cytochrome c;cytochrome c oxidase;Data;design;Development;Devices;dimer;Disease;Electrons;Energy Metabolism;Ensure;Environment;enzyme activity;enzyme mechanism;Enzymes;Estradiol;experience;Funding;Goals;heme a;heme a3;Hormones;Human;human disease;Inner mitochondrial membrane;insight;Knowledge;Life;Light;Lipids;Measurement;Membrane;Membrane Proteins;Mission;Mitochondria;Molecular;Molecular Conformation;monomer;movie;nanodisk;New York;novel therapeutic intervention;Nuclear;Outcome;Oxidants;Oxygen;particle;Play;programs;Protein Conformation;Proteins;Protons;Pump;Reaction;Research;Resolution;Respiratory Chain;Role;Series;Source;spectroscopic survey;steroid hormone;Steroids;structural biology;structural determinants;Structure;success;Techniques;Technology;Testing;Testosterone;Therapeutic;therapeutically effective;three dimensional structure;Thyroid Hormones;Time;time use;United States National Institutes of Health;Water;X-Ray Crystallography

PROJECT_TITLE: Structures of intermediates in cytochrome c oxidase

STUDY_SECTION: MSFA

STUDY_SECTION_NAME: Macromolecular Structure and Function A Study Section[MSFA]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Clinical Research;Clinical Trials and Supportive Activities;Health Services;Networking and Information Technology R&D (NITRD);Pediatric;Prevention;Screening and Brief Intervention for Substance Misuse;Substance Misuse;Telehealth;Underage Drinking

ORG_CITY: HOUSTON

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF HOUSTON

ORG_STATE: TX

PHR: PROJECT NARRATIVE Excessive alcohol consumption among college students continues to be a serious public health concern, associated with a wide range of negative consequences. Development of efficacious intervention approaches remains a priority for NIAAA. The present research proposes to evaluate a telehealth version of the Brief Alcohol Screening and Intervention for College Students (BASICS) intervention for heavy-drinking and mandated college students, which has the potential to retain the strengths of in-person interventions relative to static feedback, and can be disseminated in locations where in-person interventions are not feasible. If effective, this intervention approach will provide evidence for the efficacy of a low-cost intervention paradigm.

PI_NAMEs: NEIGHBORS, CLAYTON  (contact);PEDERSEN, ERIC R.

PROGRAM_OFFICER_NAME: KERRIDGE, BRADLEY TOWNSEND

PROJECT_TERMS: acceptability and feasibility;Accounting;Adopted;Alcohol consumption;alcohol intervention;alcohol measurement;alcohol related consequences;alcohol violation;Alcoholic beverage heavy drinker;Alcohols;Attention;Back;barrier to care;Brief Alcohol Screening and Intervention for College Students;brief intervention;college;college drinking;comparative efficacy;comparison control;cost;COVID-19 pandemic;Development;drinking;drinking behavior;Education;efficacious intervention;efficacy evaluation;efficacy testing;Expectancy;experience;Feedback;follow up assessment;Harm Reduction;hazardous drinking;Heavy Drinking;high risk population;high standard;improved;Intervention;intervention cost;intervention effect;Location;Mediating;Mediator;meetings;men;Motivation;motivational enhancement therapy;National Institute on Alcohol Abuse and Alcoholism;Online Systems;Participant;Patient Recruitments;Persons;Population;post intervention;prevent;Prevention;Privatization;programs;Public Health;Randomized;Recording of previous events;recruit;relative cost;Reporting;Research;Research Personnel;research study;Resources;response;Risk Reduction;Schedule;Schools;standard of care;Strategic Planning;student drinking;Students;substance use;telehealth;Testing;Therapeutic;Time;Training;Travel;treatment as usual;Treatment Efficacy;United States;Universities;university student;volunteer;Woman;Work;young adult

PROJECT_TITLE: Evaluating Telehealth Delivery of Brief Alcohol Screening and Intervention for College Students

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Assistive Technology;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Clinical Research;Disability Research;Hearing Loss;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Rehabilitation

ORG_CITY: CAMBRIDGE

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

ORG_STATE: MA

PHR: PROJECT NARRATIVE: People with normal hearing are typically able to recognize, understand and localize sounds of interest, even when they are embedded in mixtures of other sounds, but these abilities are often compromised in listeners with hearing disorders. The proposed research will enrich the understanding of how information in the ear gives rise to auditory behavior and how impairments in the ear alter behavior. The results will likely provide insight into the basis of listening difficulties, potentially leading to improved remediation strategies.

PI_NAMEs: MCDERMOTT, JOSH H (contact)

PROGRAM_OFFICER_NAME: MILLER, ROGER

PROJECT_TERMS: Acoustic Nerve;Address;Age;Aging;Algorithms;Attention;Auditory;Auditory Perception;auditory processing;Auditory system;Behavior;Behavioral;Behavioral Assay;behavioral impairment;Benchmarking;Binaural;Brain;Classification;Clinical;Cochlea;Cochlear Implants;computer framework;Computer Models;Data;deep learning;Dependence;Development;Devices;Ear;experimental study;Fiber;Frustration;Future;Generations;Goals;Hearing;Hearing Aids;hearing impairment;Hearing problem;Human;Human Characteristics;human model;Impairment;Implant;improved;Inner Hair Cells;insight;interest;Intervention;Judgment;Link;Location;Machine Learning;Measures;model building;Modeling;Nerve Fibers;Neurodevelopmental Disorder;Neurons;Noise;normal hearing;Outer Hair Cells;Perception;Performance;Peripheral;Persons;predictive modeling;Property;Prosthesis;remediation;Reporting;Research;Role;selective attention;Sensory;signal processing;Social isolation;sound;Sound Localization;Source;Speech;speech in noise;System;Testing;Therapeutic Intervention;trait;Voice;Work

PROJECT_TITLE: Computational Models of Normal and Impaired Hearing

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Hematology;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza;Rare Diseases;Sepsis

ORG_CITY: BATON ROUGE

ORG_DEPT: PATHOLOGY

ORG_NAME: LOUISIANA STATE UNIV A&M COL BATON ROUGE

ORG_STATE: LA

PHR: NARRATIVE Pneumonia followed by sepsis is a growing public health threat. The primary cause of death in pneumonia patients is sepsis and extrapulmonary organ failure rather than respiratory failure. The proposal will provide novel insights into the organ dysfunction in pneumonia-derived sepsis to improve therapeutic strategies.

PI_NAMEs: JEYASEELAN, SAMITHAMBY  (contact)

PROGRAM_OFFICER_NAME: MINNICOZZI, MICHAEL

PROJECT_TERMS: Ablation;Acute Lung Injury;Acute Respiratory Distress Syndrome;Adoptive Transfer;Alveolar;Alveolar Macrophages;Anti-Bacterial Agents;Antibiotic Resistance;Antibiotics;Antioxidants;Bacterial Drug Resistance;Bacterial Pneumonia;bacterial resistance;Binding;Blood;Bone Marrow;Bone Marrow Examination;carbapenem resistance;Cause of Death;Cell Nucleus;Cells;cigarette smoke-induced;Clinical Research;Cytosol;Data Display;Death Rate;design;Disease;Edema;Emergency Situation;Enterobacteriaceae;Extrinsic asthma;Functional disorder;Gene Expression;Generations;Genes;Genetic Transcription;Goals;Granulopoiesis;Hematopoietic;Host Defense;Human;Hypoxia;Immune system;Impairment;improved;In Vitro;in vivo;Infection;Inflammatory;innate immune function;insight;Klebsiella pneumoniae;knock-down;Knock-out;Knockout Mice;Lactams;Leukocytes;Life;Lung;Lung infections;Macrophage;Marrow;Methods;migration;Modeling;mouse model;Multi-Drug Resistance;Mus;Myeloid Cells;Natural Immunity;neutrophil;novel;nuclear factor-erythroid 2;Organ;Organ failure;organ injury;Outcome;overexpression;Oxidative Stress;pathogen;Pathogenesis;Patients;peripheral blood;Phagocytes;Pneumonia;Predisposition;Pseudomonas aeruginosa;Public Health;Pulmonary Emphysema;recruit;resistant Klebsiella pneumoniae;resistant strain;Resolution;Respiratory Failure;response;Response Elements;Role;Sepsis;Septic Shock;Septicemia;Signal Transduction;Small Interfering RNA;Staphylococcus aureus;stem cells;Stress;targeted treatment;Testing;Therapeutic;Tissues;transcription factor;vaccine access;Ventilator

PROJECT_TITLE: Inflammatory Organ Injury after Pneumonia-Derived Sepsis

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cardiovascular;Clinical Research;Gene Therapy;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Nanotechnology

PHR: Despite advances in the treatment of cardiovascular disease, therapies that directly target the heart are lacking. The proposed research uses newly discovered lipid nanoparticles with unprecedented targeting to the heart to deliver agents that can remodel the microtubule network - a scaffolding within the cardiomyocyte that can lead to impaired heart contraction. We will test the lipid nanoparticle therapies in two clinically relevant models of heart failure, as well as in human heart samples, supportive of lipid nanoparticles as a general method for targeting therapy to the heart.

PI_NAMEs: MARGULIES, KENNETH BER (contact);MUZYKANTOV, VLADIMIR R;WEISSMAN, DREW

PROGRAM_OFFICER_NAME: DANTHI, NARASIMHAN

PROJECT_TERMS: Acute;Acute myocardial infarction;Affect;Age;alpha Tubulin;Animal Model;Antisense Oligonucleotides;Apolipoprotein E;Binding;Blood;Cardiac;Cardiac Myocytes;Cardiomyopathies;Cardiovascular Diseases;cell type;Cells;Chronic;Clinical;clinical translation;clinically relevant;Complex;Coronary;delivery vehicle;Development;Disease;disease model;EFRAC;Endothelium;experimental study;Functional disorder;Gene Expression;gene therapy;Genes;Grant;Heart;Heart failure;Heart Transplantation;hemodynamics;Human;Impairment;improved;in vivo;Inherited;Injections;Kinetics;knock-down;Knock-out;Ligation;Link;lipid nanoparticle;Liver;MALAT1 gene;Mechanics;Mediating;Medical;Methods;Microtubules;Modeling;Molecular Chaperones;Molecular Target;Morphology;Motion;Mus;Myocardial;Myocardial Contraction;Myocardial dysfunction;Myocardial Infarction;Myocardium;novel;nucleic acid delivery;Nucleic Acids;Nucleotides;Obesity;Outcome;Outcome Measure;Perfusion;pharmacologic;Preparation;preservation;Proteins;Randomized;Rattus;Reagent;receptor;Relaxation;Research;Research Design;restraint;RNA;RNA delivery;RNA vaccine;Sampling;scaffold;single nucleus RNA-sequencing;Slice;small hairpin RNA;Small Interfering RNA;Small RNA;Solid;Structure;success;System;targeted treatment;Testing;Therapeutic;therapeutic nanoparticles;therapeutic RNA;therapeutic target;Tissues;Transcript;transcriptomics;Transplant Recipients;Tubulin;uptake;viscoelasticity;Work

PROJECT_TITLE: Cardiac delivery of RNA to treat contractile disorder

STUDY_SECTION: TDPS

STUDY_SECTION_NAME: Therapeutic Development and Preclinical Studies Study Section[TDPS]


NIH_SPENDING_CATS: Neurosciences

ORG_CITY: SYRACUSE

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UPSTATE MEDICAL UNIVERSITY

PHR: Project Narrative Restoring coordinated, rapid neuronal signaling is a goal of myelin repair therapies in diseases such as multiple sclerosis, where myelin sheath loss leads to disability. Here we combine innovative 3-D myelinating cell cultures and in vivo analysis to identify developmental mechanisms that establish myelin sheath properties expected to enable precise neuronal signaling. Results from this work will reveal fundamental cellular and molecular mechanisms as a step towards the goal of devising strategies to restore myelin for fidelity of neuronal signaling in neurological disorders.

PI_NAMEs: BECHLER, MARIE E (contact)

PROGRAM_OFFICER_NAME: TYLER, WILLIAM A

PROJECT_TERMS: 3-Dimensional;Address;antagonist;Architecture;Axon;Biochemical;Calcium;Caliber;Cell Culture Techniques;Cellular biology;Central Nervous System;Chemicals;Controlled Environment;Cues;Data;Development;Diameter;disability;Disease;Face;Fiber;Future;Goals;Growth;Image;in vivo;in vivo evaluation;Individual;innovation;Instruction;Ion Channel;knock-down;Knowledge;Length;life span;Light;Measures;mechanotransduction;Mediating;Methods;Modeling;Molecular;Multiple Sclerosis;Mus;Myelin;Myelin Sheath;myelination;Nervous System Disorder;Nervous System Physiology;neural network;Neurologic;Neurons;neurotransmission;Oligodendroglia;optogenetics;phosphoproteomics;Phosphotransferases;Piezo 1 ion channel;Process;Property;Protein Biosynthesis;Proteins;Proteomics;remediation;remyelination;repaired;response;restoration;Role;sensor;Signal Transduction;Slice;Speed;System;Testing;Tissues;tool;Translating;Translations;Variant;Work

PROJECT_TITLE: Mechanotransduction Control of CNS Myelin Sheath Length.

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Burden of Illness;Clinical Research;Contraception/Reproduction;Fibroid Tumors (Uterine);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: PROJECT NARRATIVE Fibroids are the most common pelvic tumors in women of reproductive age, incurring significant health care costs and morbidity, and are two to three times as common among Black women compared to White women. This study will seek to identify factors that explain the differences in fibroid incidence between Black and White women. The identification of how established fibroid risk factors, psychosocial factors, environmental factors, and structural racism contribute to the racial disparity in fibroid incidence could lay the groundwork for identifying strategies that would reduce fibroid incidence, particularly among Black women.

PI_NAMEs: HARRIS, HOLLY RUTH (contact);ROSENBERG, LYNN

PROGRAM_OFFICER_NAME: TINGEN, CANDACE M

PROJECT_TERMS: Accounting;Age;Age at Menarche;Air Pollution;Attention;biobank;black women;Body Size;child bearing;Clinical;cohort;Consumption;Data;data harmonization;Depo Provera;Disparity;Disproportionately impacts women;economic impact;Environmental Exposure;Environmental Impact;Environmental Risk Factor;Epidemiologic Methods;experience;Fibroid Tumor;First Births;follow-up;Foundations;Future;Health;Health Care Costs;Healthcare;Hemorrhage;Hysterectomy;Incidence;indexing;Individual;Infertility;Infrastructure;Life Style;lifestyle factors;Measures;Mediation;Methods;Modeling;Morbidity - disease rate;Neighborhoods;Newly Diagnosed;Nitrogen Dioxide;Non-Malignant;novel;Nurses' Health Study;Odds Ratio;Ozone;Pain;parity;Participant;Particulate Matter;Pelvic Pain;Pelvis;pollutant;Population;Population Attributable Risks;Positioning Attribute;Pregnancy Complications;Prevalence;prevent;prospective;Prospective cohort;psychosocial;Psychosocial Factor;Public Health;Quality of life;Race;racial disparity;racism;reproductive;Reproductive History;Research;residential segregation;Resources;Risk;Risk Factors;Role;Smoking;Smooth Muscle Tumor;Stress;Structural Racism;Symptoms;tumor;Uterine Fibroids;White Women;Woman;Women's Health;Women's study;Work

PROJECT_TITLE: Examination of factors influencing the racial disparity in fibroid incidence

STUDY_SECTION: RPPH

STUDY_SECTION_NAME: Reproductive, Perinatal and Pediatric Health Study Section[RPPH]


ORG_DEPT: BIOCHEMISTRY

ORG_NAME: EMORY UNIVERSITY

PHR: PROJECT NARRATIVE The proposed research has a strong public health need because the respiratory syncytial virus (RSV) is the top cause of lower respiratory tract infections among young children and older adults in the US and worldwide. RSV RNA synthesis machinery remains a high priority among non-segmented negative-sense (NNS) RNA viruses, and we seek to understand the molecular mechanism by elucidating the atomic details of the interaction surfaces and catalytic domains. The proposed research meets the NIH’s mission of reducing illness and disability caused by RSV and related NNS RNA viruses.

PI_NAMEs: LIANG, BO  (contact)

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TERMS: Active Sites;Anti-viral Agents;antiviral drug development;Area;Binding;Biochemical;Biochemistry;Biological Assay;Biological Models;Catalytic Domain;Child;Childhood;Classification;cofactor;Cryoelectron Microscopy;Crystallography;Data;disability;Dissection;DNA-Directed RNA Polymerase;Ebola;Ensure;Enzymatic Biochemistry;Enzymes;Funding;Genetic;Genetic Transcription;Glycine decarboxylase;Goals;Grant;Hybrids;In Vitro;Knowledge;Legal patent;Lower Respiratory Tract Infection;Measles;Methods;Methylation;Methyltransferase;Mission;Molecular;Mutagenesis;novel;Nucleotides;older adult;Pathogenicity;phosphodiester;Phosphoproteins;Polyadenylation;Polymerase;polymerization;Polymers;Process;promoter;protein complex;Proteins;Public Health;Publications;Rabies;Reaction;reconstitution;Regulation;Reporting;Research;Respiratory Disease;Respiratory syncytial virus;Respiratory Syncytial Virus Infections;RNA;RNA chemical synthesis;RNA methylation;RNA Viruses;RNA-Directed RNA Polymerase;Role;Solid;Structure;success;Surface;Testing;transcription factor;transcriptome sequencing;United States National Institutes of Health;Vesicular stomatitis Indiana virus;Viral;Viral Genome;Viral Proteins;virology;Virus

PROJECT_TITLE: Structure and Regulation of The Respiratory Syncytial Virus Polymerase

STUDY_SECTION: MSFC

STUDY_SECTION_NAME: Macromolecular Structure and Function C Study Section[MSFC]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Breast Cancer;Cancer;Genetics;Prevention;Women's Health Research

ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

ORG_STATE: CA

PHR: PROJECT NARRATIVE  Breast cancer arises from breast epithelial cells that gather pro-tumorigenic mutations leading to uncontrolled cell proliferation and tumor initiation. Knowledge of how tumor initiation can be regulated by the cellular microenvironment will enable us to specifically interfere with the function of tumor-initiating cells to stop tumor growth and potentially recurrence of breast cancer. In this renewal, we will explore the emergence precancer-associated fibroblasts (preCAFs) and define their role in reshaping the breast immune microenvironment in the pre-malignant breast of BRCA1 mutation carriers. This may ultimately lead to the development of novel therapeutic approaches for primary cancer prevention and to treat patients suffering from breast cancer.

PI_NAMEs: KESSENBROCK, KAI  (contact)

PROGRAM_OFFICER_NAME: KAI, MIHOKO

PROJECT_TERMS: Address;Affect;Biological Assay;Breast;Breast Cancer Model;Breast Epithelial Cells;breast tumorigenesis;cancer initiation;Cancer-Predisposing Gene;Cell Proliferation;cell type;Cells;Coculture Techniques;cohort;Computer Analysis;Cues;CXCL2 gene;Data;Data Set;Development;DNA Damage;DNA Repair;Epithelial Cells;epithelial stem cell;Epithelium;Event;exhaustion;Fibroblasts;Funding;Genetic;Genomic Instability;Germ Lines;Heterozygote;Homologous Gene;Human;human disease;IL8 gene;Immune;immunoregulation;In Vitro;in vivo;Incidence;Infiltration;Inflammation Mediators;Inflammatory;Knowledge;Lead;Malignant Breast Neoplasm;Malignant Neoplasms;mammary epithelium;Mammary Gland Parenchyma;Maps;Modeling;Molecular;mouse model;Mus;Mutation;mutation carrier;Myeloid Cells;Myeloid-derived suppressor cells;neutrophil;NF-kappa B;novel therapeutic intervention;paracrine;Patients;Phenotype;Population;precision cancer prevention;premalignant;Prevention strategy;Primary Cancer Prevention;recruit;Recurrence;Regulation;Role;Shapes;Signal Transduction;Stromelysin 1;System;T-Lymphocyte;Testing;Tissue Sample;transcriptomics;transplant model;Transplantation;tumor growth;tumor initiation;tumor progression;Tumor Suppressor Genes;tumor-immune system interactions;tumorigenesis;tumorigenic;Work

PROJECT_TITLE: Microenvironmental regulation of breast tumorigenesis

STUDY_SECTION: THI

STUDY_SECTION_NAME: Tumor Host Interactions Study Section[THI]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Genetics;Infectious Diseases;Kidney Disease;Urologic Diseases

ORG_CITY: NEW YORK

ORG_DEPT: SURGERY

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: NARRATIVE The upper urinary tract exhibits peristaltic contractions that propel wastes from the kidney to the bladder. Defects in upper urinary tract peristalsis, such as vesicoureteral reflux, are prevalent and associated with a high morbidity. In this proposal, we will define the signaling mechanisms that underlie upper urinary tract peristalsis defects, as well as identify the potential of drugs to treat these defects.

PI_NAMEs: HURTADO, ROMULO  (contact)

PROGRAM_OFFICER_NAME: BRUNSKILL, ERIC WAYNE

PROJECT_TERMS: Affect;Automobile Driving;Binding;Binding Proteins;Biological Assay;Bladder;Cell Differentiation process;Cells;Child;Childhood;Chronic;cofactor;Complex;conditional knockout;Congenital Abnormality;Contracts;cost;Coupled;Defect;Development;Diagnostic;Electrophysiology (science);End stage renal failure;Erinaceidae;Etiology;Excretory function;Exhibits;Functional disorder;Future;Genetic;Genetic Markers;Genetic Transcription;Goals;Human;Hydronephrosis;Immunoprecipitation;Impairment;insight;Ion Channel;Kidney;Kidney Diseases;Kidney Failure;Knockout Mice;Knowledge;Maps;Measurement;Mediating;Morbidity - disease rate;mouse model;Muscle;mutant mouse model;nodal myocyte;novel;Nuclear Matrix;Nuclear Proteins;Obstruction;Operative Surgical Procedures;Optics;Organ;organ growth;Pacemakers;patch clamp;Pathologic;Pathologic Processes;Pathology;Pathway interactions;Peristalsis;Pharmaceutical Preparations;Physiological;Physiology;Population;pressure;Process;protein biomarkers;Proteins;real-time images;Reflux;Regulation;renal damage;Renal Tissue;Research;Role;Scaffolding Protein;Signal Transduction;Smooth Muscle;smoothened signaling pathway;Specific qualifier value;stem cells;Techniques;transcription factor;transcriptomics;urinary;Urinary tract;Urinary tract infection;Urinary Tract Physiology;Urine;Urologic Diseases;Vesico-Ureteral Reflux;wasting

PROJECT_TITLE: Defining the onset and regulation of myogenic upper urinary tract physiology

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 KUDS-W (04)]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Nutrition;Obesity;Pediatric;Pediatric Cancer;Prevention;Rare Diseases;Rehabilitation;Telehealth

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: PROJECT NARRATIVE Childhood cancer survivors are a growing cohort of individuals with both modifiable and non-modifiable risk factors for premature cardiovascular morbidity and mortality. This phase IIb randomized trial will test whether time-restricted eating can be deployed as a feasible, sustainable, risk-reducing measure to reduce weight and cardiometabolic risk in radiation-exposed childhood cancer survivors with overweight/obesity. This intervention may provide an important, scalable tool to combat the obesity epidemic and survivor-specific cardiometabolic risk and thereby improve the longitudinal health of survivors of childhood cancer.

PI_NAMEs: FRIEDMAN, DANIELLE  (contact)

PROGRAM_OFFICER_NAME: AGURS-COLLINS, TANYA

PROJECT_TERMS: Abdomen;Abstinence;Address;Adherence;adherence rate;Adipocytes;adipokines;adiponectin;Adipose tissue;Adult;Affect;Age;aged;American;Behavior;Behavior Therapy;Biological Markers;biopsychosocial factor;Blood;Blood Pressure;Bluetooth;Body Composition;Body fat;Body mass index;Body Weight decreased;Breast Cancer survivor;Caloric Restriction;Cancer Burden;cancer recurrence;Cancer Survivor;cardiometabolic risk;cardiometabolism;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;Cardiovascular system;Central obesity;Cessation of life;Chest;childhood cancer survivor;Childhood Cancer Survivor Study;Chronic;circadian;Circadian Rhythms;cohort;combat;Communities;comorbidity;Devices;Diabetes Mellitus;Diet;dietary restriction;digital;Dryness;Dyslipidemias;Eating;Education;Educational Materials;effective intervention;efficacy evaluation;Energy Intake;Enrollment;Exposure to;Fasting;Functional disorder;Funding;future implementation;General Population;Glucose;glycemic control;Goals;Health;Healthy Eating;healthy lifestyle;high risk population;Hour;Human;Hypertension;implementation efforts;improved;Incidence;Individual;Inflammation;inflammatory marker;Institution;Insulin;Insulin Resistance;Interleukin-6;Intervention;Intervention Studies;Interview;Leptin;Life;Life Style;lifestyle intervention;Lipids;live text;Maintenance;Malignant Childhood Neoplasm;Measures;Mediating;Metabolic;metabolic profile;mHealth;Modality;modifiable risk;Monitor;Morbidity - disease rate;mortality;motivational enhancement therapy;neoplasm resource;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;Obesity Epidemic;Outcome;Overweight;Pancreas;Participant;Patient Recruitments;Patient Self-Report;Pediatric Neoplasm;Phase;Population;Population Heterogeneity;preclinical study;premature;primary outcome;Questionnaires;Radiation;Radiation exposure;Randomized;randomized trial;Randomized, Controlled Trials;remote delivery;Reporting;Risk;Risk Factors;Risk Reduction;Sampling;sedentary lifestyle;Self Efficacy;social cognitive theory;Spottings;Structure;Subgroup;Survivors;Technology;Testing;Therapeutic;Thermogenesis;Time-restricted feeding;tool;treatment as usual;United States;virtual visit;waist circumference;Weight;Weights and Measures;Work

PROJECT_TITLE: Decreasing Cardiometabolic Risk in Survivors of Childhood Cancer: Survivors engaged in Time-Restricted EatiNG after THerapy (STRENGTH)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CCHI-W (02)]


NIH_SPENDING_CATS: Antimicrobial Resistance;Infectious Diseases;Malaria;Orphan Drug;Rare Diseases;Vector-Borne Diseases

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

PHR: Project Narrative Malaria is a huge global health problem with 254 million cases per year and more than 617,000 deaths annually. Our goal is to develop small chemical molecules that target an essential protein- degrading enzyme of malaria-causing plasmodium parasites. The study will provide preclinical compounds for further development as anti-malarial therapeutics.

PI_NAMEs: LIN, GANG  (contact)

PROGRAM_OFFICER_NAME: JOY, DEIRDRE A

PROJECT_TERMS: 5 year old;Achievement;Active Sites;Address;Africa South of the Sahara;African;Age;Animal Model;Anti-malarials;Artemisinins;Binding;Biochemistry;Biological Availability;cancer therapy;Catalytic Domain;Cell Death;Cell Physiology;Cessation of life;Chemicals;Child;Clinical;clinical development;Communicable Diseases;Complex;COVID-19 pandemic;Cryoelectron Microscopy;Development;Drug Kinetics;Drug resistance;Drug Targeting;Enzymes;Eukaryota;Evaluation;FDA approved;Feedback;Genetic Transcription;global health;Goals;Human;Hydrogen Bonding;improved;In Vitro;in vivo;Infection;inhibitor;insight;Life Cycle Stages;Liver;Malaria;malaria infection;Measures;mortality;mouse model;multicatalytic endopeptidase complex;mutant;Mutation;novel;Oral;Parasitemia;Parasites;Peptides;Pharmaceutical Chemistry;Pharmaceutical Preparations;Plasmodium;Plasmodium falciparum;Play;pre-clinical;preservation;Program Development;Property;prophylactic;Proteasome Inhibitor;Proteins;proteostasis;Regulation;Reporting;Resistance;resistance mechanism;response;Role;Series;Site;Structure;Structure-Activity Relationship;Testing;Therapeutic;transmission blocking;transmission process;Treatment Efficacy;vector control;World Health Organization

PROJECT_TITLE: Selective Plasmodium proteasome inhibitors as novel multi-stage antimalarials

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 DCAI-T (90)]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Mental Health;Mental Illness;Prevention;Suicide;Suicide Prevention

ORG_DEPT: PSYCHIATRY

PHR: PROJECT NARRATIVE Suicide risk is high in middle-aged and older adults, and especially in those who have been recently hospitalized for suicidal ideation or behavior. The goal of this project is to evaluate the predictive association of emotion reactivity and cognitive reappraisal with suicidal ideation in middle-aged and older adults (40-90 years old) who have been discharged from a suicide-related hospitalization. Understanding this relationship may help identify suicide risk factors and subgroups of patients at high suicide risk.

PI_NAMEs: KIOSSES, DIMITRIS N (contact)

PROGRAM_OFFICER_NAME: LYONS, ELIZABETH ANNE

PROJECT_TERMS: Admission activity;Affect;Biometry;Characteristics;Clinical;Cognition;cognitive control;cognitive reappraisal;comorbidity;complement C2b;Data;Development;Diabetes Mellitus;Electroencephalography;emotion regulation;Emotional;Emotions;Equipment and supply inventories;Event-Related Potentials;Feeling suicidal;Goals;hospital readmission;Hospitalization;Hospitals;innovation;instrument;Interviewer;Loneliness;Measurement;Measures;Medical;Mental Depression;middle age;National Institute of Mental Health;older adult;Participant;Patient Self-Report;patient subsets;Patients;perceived stress;Population Intervention;precision medicine;Process;Psychiatric Diagnosis;Psychophysiology;psychosocial;Public Health;Questionnaires;Race;recruit;Regulation;Research;Research Domain Criteria;response;Rest;Risk Factors;Severities;sex;Stimulus;Strategic Planning;suicidal;suicidal behavior;suicidal risk;Suicide;Suicide prevention

PROJECT_TITLE: Emotion Reactivity, Cognitive Reappraisal, and Suicidal Ideation In Middle-aged and Older Adults at High Suicide Risk

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


ED_INST_TYPE: OTHER SPECIALIZED SCHOOLS

ORG_DEPT: MISCELLANEOUS

PHR: Electrophysiology is essential in developing novel therapeutics against cardiovascular diseases, the leading cause of death worldwide. This proposal introduces a novel nanophotonic device to wirelessly perform electrophysiological studies of cardiac models in vitro with unprecedented resolution and long-term stability. This technological development is projected to impact fundamental and translational cardiac research significantly and, in the long term, contribute to relieving the social and economic burden of cardiovascular disorders on society.

PI_NAMEs: SARKAR, DEBLINA  (contact)

PROGRAM_OFFICER_NAME: THAKAR, RAHUL GAUTAM

PROJECT_TERMS: Acceleration;Action Potentials;Affect;aged;Amplifiers;Arrhythmia;Biological;Biological Assay;Cardiac;Cardiac Myocytes;Cardiovascular Diseases;Cardiovascular system;Cause of Death;Cells;Cessation of life;Characteristics;Complex;Coupling;Darkness;density;design;Development;Devices;Diameter;Disabling;Economic Burden;Electrophysiology (science);Electroporation;Environmental Risk Factor;Evaluation;Event;experimental study;extracellular;Fluorescence;Gap Junctions;genetic manipulation;Gold;Government;Heart;Heart Diseases;Heart Research;Hour;In Vitro;in vitro Model;innovation;Laboratories;Lateral;Light;light scattering;Location;manufacture;Medicine;Membrane;Membrane Potentials;meter;Methods;Microelectrodes;Microfluidics;Microscope;Microscopic;Microscopy;Modeling;Monitor;monolayer;Morbidity - disease rate;mortality;multi-electrode arrays;Myocardial Infarction;nano;nanoelectrodes;nanofabrication;nanoneedle;nanophotonic;nanoscale;Nanostructures;Nature;new technology;novel;novel therapeutics;Optical reporter;Optics;Outcome;patch clamp;Patch-Clamp Techniques;Pattern;Performance;Persons;Pharmacology Study;Photobleaching;Physiological;plasmonics;Play;prevent;Process;professor;Property;prospective;Reporter;Research;Resistance;Resolution;response;Role;seal;Shapes;Site;social;Societies;Sodium Channel;Specialist;Structure;System;Techniques;Technology;technology development;Time;Tissues;Translations;United States;voltage;voltage sensitive dye;wireless

PROJECT_TITLE: Multi-electroplasmonic nanoantenna arrays for wireless transmembrane-level recording of cardiomyocyte action potentials with sub-micrometer resolution

STUDY_SECTION: ISD

STUDY_SECTION_NAME: Instrumentation and Systems Development Study Section[ISD]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Clinical Research;Contraception/Reproduction;Depression;Estrogen;Menopause;Mental Health;Mental Illness;Neurosciences;Nutrition;Prevention;Women's Health Research

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: The mechanism causing depression and anxiety in the menopause transition is surprisingly unknown, precluding prevention, treatment and cure. This naturalistic longitudinal study of women who choose to undergo surgical menopause will test a novel mechanism in which follicle-stimulating hormone (FSH) and acyl-ghrelin produce an inflammatory state involving autonomic signaling that underpins depressive and anxiety symptoms. Burgeoning knowledge has expanded the actions of these two hormones beyond their well-known roles in reproduction and feeding into aging, enhancing the plausibility that our hypothesis could impact the health of women.

PI_NAMEs: SPICER, JULIE A (contact)

PROJECT_TERMS: adipokines;Adult;Age;Aging;antagonist;Anti-Inflammatory Agents;anti-microbial peptide;Anxiety;anxiety symptoms;Autonomic nervous system;Bilateral;Biological;Biological Assay;blood-brain barrier crossing;Case/Control Studies;Cells;Clinical;Communities;comparison control;cytokine;Data;depressive symptoms;design;Detection;Education;Endocrine;Enzyme-Linked Immunosorbent Assay;Estradiol;Estradiol Receptors;Estrogens;experience;feeding;Fertility;Follicle Stimulating Hormone;Follicle Stimulating Hormone Receptor;ghrelin;ghrelin receptor;Goals;Gynecologic Surgical Procedures;Health;Healthcare;heart rate variability;High Risk Woman;Hormonal;hormonal signals;Hormones;Hunger;Immune;Impairment;Inflammation;Inflammatory;inflammatory marker;innovation;inter-individual variation;Intervention;Knowledge;Leadership;Link;Lipids;Lipopolysaccharides;Liver;Longitudinal Studies;Measures;Mediation;Menopause;Mental Depression;Modeling;monocyte;mood symptom;Moods;multiplex assay;neuroinflammation;novel;Occupational;Osteoporosis;Outcome;Pathway interactions;Perimenopause;Peripheral;Persons;Plasma;Postmenopause;Premenopause;prevent;Prevention;Production;Productivity;Progesterone;prospective;psychiatric symptom;psychologic;Public Health;Receptor Activation;Receptor Signaling;recruit;Reflex action;Reproduction;reproductive hormone;Research;Rest;Risk;Risk Reduction;Role;Salpingo-Oophorectomy;Signal Transduction;social;suicide rate;surgical menopause;Symptoms;Testing;Time;Tissues;Vagus nerve structure;Woman;Women's Health;Women's study;Work

PROJECT_TITLE: Hormonal Drivers of Perimenopausal Inflammation and Mood Symptoms

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Estrogen;Neurosciences;Substance Misuse;Women's Health Research

ORG_DEPT: PHARMACOLOGY

PHR: Project Narrative Binge alcohol drinking is a major risk factor for neuropsychiatric diseases including alcohol use disorder, and women are more likely to develop these diseases with a shorter history of alcohol consumption and suffer greater negative effects of binge drinking. The research proposed here will characterize the mechanisms by which the sex hormone estrogen dynamically controls alcohol drinking behavior in female mice through rapid modulation of critical brain circuits in real time. This work may identify novel targets for intervention and prevention of excessive alcohol drinking, especially in women.

PI_NAMEs: PLEIL, KRISTEN ELIZABETH (contact)

PROGRAM_OFFICER_NAME: LIU, QI-YING

PROJECT_TERMS: Action Potentials;Acute;Affect;Alcohol consumption;Alcohol dependence;alcohol use disorder;Alcoholic Intoxication;Anatomy;Anti-Anxiety Agents;Behavior;binge drinking;biological adaptation to stress;Biosensor;Birds;Brain;Cardiovascular Diseases;Complex;Corticotropin-Releasing Hormone Receptors;Development;Disease;Dose;drinking;drinking behavior;Electrophysiology (science);ESR1 gene;Estradiol;Estrogen Receptors;Estrogens;Estrous Cycle;excessive behavior;Female;G-Protein-Coupled Receptors;Genomics;Glutamates;Gonadal Steroid Hormones;Health;Heavy Drinking;Hippocampus;Hormonal;Hour;Hypothalamic structure;Image;improved;inhibitor;insight;Intervention;Ion Channel Gating;Limbic System;Literature;Liver;male;Malignant Neoplasms;Mammals;Maps;Measures;Mediating;Membrane;men;Metabolic Diseases;Molecular Profiling;Mus;Neurons;neuropsychiatric disorder;neurotransmitter release;non-genomic;novel;Outcome;Ovarian;Ovarian hormone;Ovariectomy;Peptides;Physiological;Play;Population Projection;postsynaptic;preclinical study;presynaptic;Prevention;Puberty;Public Health;receptor;Receptor Signaling;Recording of previous events;reproductive;Research;Rewards;Risk;Risk Factors;RNA Interference;Rodent;Role;Signal Transduction;single nucleus RNA-sequencing;Site;Slice;Synapses;Testing;therapeutically effective;Time;Toxic effect;voltage;Woman;Work

PROJECT_TITLE: The role of rapid estrogen signaling in alcohol drinking behavior

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric

ORG_DEPT: PEDIATRICS

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE Increasing evidence suggests that cerebellar dysfunction is a key contributor to the pathogenesis of cognitive, communication, motor, and behavioral co-morbidities observed in neurodevelopmental disorders (NDDs), but the mechanistic insight to this relationship is still nascent. The proposed research will leverage parallel approaches in humans and mouse models of EBF3-related NDDs to provide insights into the molecular and cellular role of the COE-transcription factor EBF3 in cerebellar development and define the mechanisms of cerebellar inhibitory neuronal dysfunction in NDDs. The unique findings will have broad implications for advancing both cerebellar neuroscience and our understanding of the pathophysiology of cerebellar inhibitory neuronal dysfunction in NDD pathogenesis.

PI_NAMEs: CHAO, HSIAO-TUAN  (contact)

PROGRAM_OFFICER_NAME: RIDDLE, ROBERT D

PROJECT_TERMS: Abnormal coordination;Affect;Alleles;Anxiety;Ataxia;Attention deficit hyperactivity disorder;autism spectrum disorder;B-Lymphocytes;Behavior;Behavioral;behavioral study;Biological Markers;Brain;brain magnetic resonance imaging;Brain region;candidate identification;cell type;Cells;Cerebellar Diseases;Cerebellar vermis structure;Cerebellum;Cleavage Under Targets and Release Using Nuclease;Cognition;Cognitive;cohort;Communication;comorbidity;Complex;Defect;Development;Diagnostic;differential expression;Disease;Dissection;Drosophila genus;Electrophysiology (science);Embryo;Epilepsy;Etiology;excitatory neuron;executive function;Fibroblasts;Functional disorder;Gene Deletion;gene regulatory network;Genes;Genotype;Goals;granule cell;Homologous Gene;Human;human model;Immunohistochemistry;Impairment;in vivo;Individual;information processing;inhibitory neuron;innovation;insight;Intellectual functioning disability;Interneurons;Language;Lesion;loss of function;Loss of Heterozygosity;malformation;Mediator;Mendelian disorder;Molecular;Morbidity - disease rate;Motor;mouse model;Movement;multimodality;Mus;Muscle hypotonia;Neuroanatomy;neurobehavioral;Neurodevelopmental Disorder;neuron development;Neuronal Differentiation;Neuronal Dysfunction;Neurons;neuropsychiatry;Neurosciences;neurotransmission;Pathogenesis;Pathway interactions;Phenotype;postnatal;Process;Proliferating;Purkinje Cells;recruit;Regulation;Reporting;Research;Role;Sensory;Severity of illness;SHH gene;Signal Transduction;single-cell RNA sequencing;Skin;Slice;smoothened signaling pathway;Social Behavior;Specific qualifier value;Syndrome;Time;Tissue-Specific Gene Expression;transcription factor;Transcription Factor 3;transcriptome sequencing;transcriptomics;Variant;Wild Type Mouse;Zinc Fingers

PROJECT_TITLE: Molecular and Cellular Mechanisms of Cerebellar Dysfunction in Neurodevelopmental disorders

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: Nashville

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: Project Narrative We propose to elucidate the molecular mechanism of arrestin-1 binding to rhodopsin, design arrestin-1 mutants that compensate for defects of rhodopsin phosphorylation in vivo, and identify novel interaction partners of arrestin-1 in rod photoreceptors. To this end, we propose to use direct binding assay with phosphorylated and unphosphorylated light-activated and dark rhodopsin, in vivo electroretinography in mice, ex vivo single cell recordings of rod photoreceptors, and in vivo proximity labeling with subsequent mass-spectrometry.

PI_NAMEs: GUREVICH, VSEVOLOD V. (contact)

PROGRAM_OFFICER_NAME: NEUHOLD, LISA

PROJECT_TERMS: Acceleration;Affinity;arrestin 1;Arrestins;Avidin;Binding;Biological Assay;Biotin;Biotinylation;Cells;Characteristics;clinically relevant;Collaborations;Compensation;Complex;Darkness;Data;Defect;Dependovirus;design;Electroretinography;Elements;Engineering;Ensure;experimental study;G-Protein-Coupled Receptors;gain of function;gain of function mutation;gene therapy;Gene Transfer;Goals;GRK1 gene;Human;improved;In Vitro;in vivo;in vivo Model;Label;Light;Maps;Mass Spectrum Analysis;Mediating;Modeling;Molecular;monomer;Mus;mutant;Mutation;Night Blindness;novel;Opsin;Patients;Peptides;Phosphorylation;Phosphorylation Site;Photoreceptors;preservation;Property;Protein Dephosphorylation;Proteins;receptor;Recovery;Regulation;Reproducibility;Retinal Degeneration;retinal rods;Rhodopsin;Rod;Role;screening;side effect;Signaling Protein;Site-Directed Mutagenesis;Structure;success;Testing;Therapeutic;transgene expression;Vision Disorders;Visual

PROJECT_TITLE: Structure-function studies of visual arrestin

STUDY_SECTION: BDE

STUDY_SECTION_NAME: Biology and Development of the Eye Study Section[BDE]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Nutrition;Obesity

ORG_CITY: SAN ANTONIO

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

PHR: Project Narrative: The search for novel strategies to promote both healthspan and lifespan is an important effort in geroscience research. Hyperleptinemia directly promotes cellular senescence and leptin modulation may be a novel strategy to promote both healthspan and lifespan.

PI_NAMEs: ZHAO, SHANGANG  (contact)

PROGRAM_OFFICER_NAME: WILLIAMS, JOHN

PROJECT_TERMS: Acceleration;Adipocytes;Adipose tissue;Affect;Age;age effect;age related;age-related disease;Aging;aging process;aging related;Antipsychotic Agents;Body Weight decreased;Brain;Cell Aging;Cell Count;Cellular Metabolic Process;cellular targeting;Chronic;cohort;Complex;Development;Diabetes Mellitus;Diet;diet-induced obesity;Doxycycline;driving force;extend lifespan;Functional disorder;Galactose;Genetic;genetic approach;Geroscience;Health;healthspan;High Fat Diet;Human;Impairment;improved;In Vitro;in vivo;Inflammation;Knock-out;Knockout Mice;Lead;Leptin;leptin receptor;Leptin resistance;life span;LoxP-flanked allele;Measures;Mediating;Metabolic;Metabolic Diseases;Metabolism;Molecular;Monitor;mouse model;Mus;Muscle;Muscle function;neutralizing antibody;novel;novel strategies;Obese Mice;Obesity;old mice;Phenotype;Physiology;Play;Process;Publications;receptor expression;Research;Research Personnel;Research Proposals;Resources;response;Role;senescence;senescence associated secretory phenotype;senescent cell;Shock;Signal Transduction;Supplementation;Testing;Therapeutic;Tissues;TP53 gene;Transgenic Mice;Transgenic Organisms;translational medicine;Translational Research;Visceral;Visceral fat;Weight Gain;Work

PROJECT_TITLE: Effects of leptin modulation on health span and lifespan

STUDY_SECTION: CMAD

STUDY_SECTION_NAME: Cellular Mechanisms in Aging and Development Study Section[CMAD]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention;Social Determinants of Health

ORG_CITY: FORT COLLINS

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: COLORADO STATE UNIVERSITY

ORG_STATE: CO

PHR: Project Narrative We will provide first of its kind methods to estimate health effects of environmental mixtures that account for ef  fect heterogeneity driven by multiple individual  and neighborhood level modifiers. The new methodology will advance precision environmental health research and identify individuals with increased sensitivity to environ  mental mixtures. Freely available software and vignettes will make the methods available to the wider scientific community.

PI_NAMEs: WILSON, THOMAS ANDER (contact)

PROGRAM_OFFICER_NAME: JOUBERT, BONNIE

PROJECT_TERMS: Address;Adverse effects;Air Pollutants;Air Pollution;analytical tool;Birth;Birth Weight;built environment;Characteristics;Chemical Exposure;Chemicals;Child;Child Development;Child Health;cohort;Colorado;Communities;Computer software;Data;Data Set;design;Development;disorder prevention;Educational workshop;Environment;Environmental Exposure;Environmental Health;Environmental Risk Factor;Epidemiology;Exposure to;Fetal Development;Genetic;Health;Heterogeneity;high dimensionality;Human;indexing;Individual;individual variation;innovation;insight;Journals;Life;Maternal Exposure;Measures;member;Methodology;Methods;Modeling;Movement;Neighborhoods;New England;novel;Outcome;Outcome Assessment;Outcome Measure;Paper;Pathway interactions;Perinatal;Population;precision medicine;Predisposition;Pregnancy;Prevention strategy;programs;Reaction Time;Registries;regression trees;Research;Research Personnel;response;Risk;Risk Assessment;Sentinel;sex;social;Social Environment;socioeconomics;software development;Source;Statistical Methods;Stress;stressor;Subgroup;Time;Trees;United States National Institutes of Health;user friendly software;Work;Writing

PROJECT_TITLE: Statistical Methods for Precision Environmental Health with Mixture Exposures

STUDY_SECTION: ASPB

STUDY_SECTION_NAME: Analytics and Statistics for Population Research Panel B Study Section[ASPB]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Genetics;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: Los Angeles

ORG_DEPT: ORTHOPEDICS

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: PROJECT NARRATIVE The clinical management of extensive bone injuries in humans continues to present a significant challenge. By studying new models of natural large-scale bone regeneration, we have identified a specific subpopulation of cells that is sensitive to injury and coordinates repair. In this proposal, we examine the molecular mechanisms that control these cells, with the long-term goal to develop therapeutic approaches that could heal large and difficult bone injuries in patients.

PI_NAMEs: MARIANI, FRANCESCA V (contact)

PROGRAM_OFFICER_NAME: CHEN, FAYE H

PROJECT_TERMS: Ablation;ATAC-seq;Automobile Driving;Binding;Binding Sites;Biological Assay;bone;Bone callus;Bone Injury;Bone Marrow;Bone Regeneration;bone repair;Cell Communication;Cell Lineage;Cell Physiology;cell type;Cells;Chromatin;Clinical;Clinical Management;Complex;craniofacial;Data;Dedications;Defect;Dependence;Endosteum;Erinaceidae;Event;Excision;Exhibits;experimental study;Femur;Follistatin;FOS gene;FOS Protein;Fracture;Future;Gene Expression Regulation;Generations;Genes;Genetic;Genetic Transcription;Goals;healing;Homeostasis;Hour;Human;Impaired healing;improved;Injury;injury and repair;insight;jun Oncogene;Lesion;Ligands;Mediating;Methods;Modeling;Molecular;mouse model;Mus;Muscle satellite cell;Natural regeneration;novel;novel therapeutic intervention;Nucleic Acid Regulatory Sequences;Operative Surgical Procedures;Osteoblasts;Pathway interactions;Patients;Periosteal Cell;Periosteum;periostin;Phase;Population;preclinical study;Prevalence;Process;Production;Property;rapid detection;recruit;regenerative;Regenerative capacity;repaired;reparative capacity;Reporting;Research;response;response to injury;rib bone structure;Role;Sentinel;Signal Transduction;Site;skeletal;skeletal injury;skeletal stem cell;Skeleton;Source;stem cell population;Stromal Cell-Derived Factor 1;Stromal Cells;Surgeon;Techniques;Testing;Therapeutic;Thrombospondins;Toxin;transcription factor;Transcription Factor AP-1;Transplantation;Trauma;Work

PROJECT_TITLE: Cellular and molecular coordinators of large-scale bone repair

STUDY_SECTION: SBSR

STUDY_SECTION_NAME: Skeletal Biology Structure and Regeneration Study Section[SBSR]


ADMINISTERING_IC: EB

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Breast Cancer;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Precision Medicine;Women's Health Research

ORG_CITY: DURHAM

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Project Narrative Metabolic adaptation is essential to survival, and metabolic imaging either by itself or in combination with genomics, proteomics, and metabolomics can provide a holistic understanding of how cells adapt under varying physiological and pathological microenvironments as well as serve as a predictive marker of treatment success. The goal of this proposal is to develop a portable and versatile optical imaging platform called the CapCell to characterize the metabolism of subpopulations of cells with different phenotypes and the relationship of these cells with the local microvasculature. We will use this technology to elucidate how metabolic endpoints can inform on the growth and invasion of tumor cells into adjacent host tissue, elucidate how diverse types of therapeutics inhibit the downstream efforts of tumor-promoting oncogenes, and identify biomarkers that can inform the management of cancer therapy in patients.

PI_NAMEs: GOGA, ANDREI ;RAMANUJAM, NIRMALA  (contact)

PROGRAM_OFFICER_NAME: ANDERSON, AFROUZ AZARI

PROJECT_TERMS: Acceleration;Address;Algorithms;Animals;anti-cancer research;Architecture;Area;Biological;Biological Markers;Biological Models;biological systems;Biology;biomarker identification;biomedical imaging;Blood capillaries;Blood Vessels;Breast Cancer therapy;Cancer Patient;cancer therapy;Carbon;Cardiovascular system;Cell Respiration;Cells;cellular imaging;Characteristics;Clinical;clinical translation;Clinical Trials;Companions;Dedications;density;design;Development;Diagnosis;Discipline;Disease;driver mutation;drug development;drug efficacy;efficacy evaluation;Engraftment;fatty acid oxidation;Fatty Acids;flexibility;fluorophore;Funding;Future;Genetically Engineered Mouse;Genomics;Geometry;Glucose;glucose metabolism;glucose uptake;Glycolysis;Goals;Growth;Hand;Heterogeneity;high resolution imaging;Homeostasis;Human;Image;imaging platform;imaging Segmentation;Imaging technology;in vivo;Individual;innovation;interest;Invaded;Label;Laboratories;Laboratory Scientists;Lighting;Lipids;magnetic resonance spectroscopic imaging;Malignant Breast Neoplasm;Malignant Neoplasms;Marketing;Metabolic;metabolic abnormality assessment;metabolic imaging;metabolic phenotype;metabolic profile;Metabolism;metabolomics;Microscope;mitochondrial metabolism;Modeling;Molecular Profiling;Morphology;mouse model;Mus;Mutation;MYC gene;Neighborhoods;Neoadjuvant Therapy;neoplastic cell;Neurosciences;Noise;novel therapeutics;Nucleic Acids;Nutrient;Oncogenes;Oncogenic;optical imaging;Optics;Organoids;Outcome;overexpression;oxidation;Pathologic;Pathway interactions;patient derived xenograft model;Patients;Perfusion;personalized management;Pharmaceutical Preparations;Phenotype;Physiological;portability;Positron-Emission Tomography;predictive marker;Proliferating;Proteins;Proteomics;Protocols documentation;Recurrence;Recurrent disease;Reporting;Research;Research Personnel;Residual Neoplasm;Resistance;Resolution;response;Risk;Sampling;segmentation algorithm;serial imaging;Source;success;Surveys;System;Technology;Testing;Therapeutic;therapy resistant;Tissue imaging;Tissues;tool;Training;transcriptome sequencing;treatment response;triple-negative invasive breast carcinoma;tumor;tumor behavior;Tumor Cell Invasion;Tumor Promotion;Tumor Suppressor Proteins;Variant;Visualization;Work;Xenograft procedure

PROJECT_TITLE: Development of CapCell Scope for Metabolic Imaging of Tissue Heterogeneity and Therapy Response

STUDY_SECTION: IPCA

STUDY_SECTION_NAME: Imaging Probes and Contrast Agents Study Section[IPCA]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Hematology;Human Genome;Rare Diseases

ORG_DEPT: GENETICS

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Narrative The proposed research is highly relevant to public health. The spatial organization of DNA repair establishes the balance between normal repair, a tumor suppressor mechanism, and pathological repair, yielding oncogenic chromosome rearrangements. Elucidating how DNA repair is organized 3D following DNA damage will help understand the modality of action of cancer therapies.

PI_NAMEs: GAUTIER, JEAN  (contact)

PROGRAM_OFFICER_NAME: WITKIN, KEREN L

PROJECT_TERMS: 3-Dimensional;Actins;Affect;ANGPTL2 gene;B-Lymphocytes;Biochemical Reaction;Biological Assay;cancer cell;cancer therapy;candidate identification;Cell Nucleus;Chromatin;Chromosomes;common rule;Communities;constitutive expression;Data;Development;Disease;DNA;DNA Binding;DNA biosynthesis;DNA Damage;DNA Double Strand Break;DNA lesion;DNA Repair;DNA replication fork;Double Strand Break Repair;Down-Regulation;driving force;Ensure;Equilibrium;Family member;gain of function mutation;Generations;Genes;Genetic Transcription;Genome;genome integrity;Genome Stability;genome-wide;Genomic approach;Genomic Instability;GTP Binding;Guanosine Triphosphate Phosphohydrolases;Hi-C;imaging approach;immunodeficiency;In Vitro;innovation;Link;live cell imaging;Maintenance;Mammalian Cell;Measures;mechanical force;Membrane;Microscopy;Modality;Modeling;Monitor;Monomeric GTP-Binding Proteins;Movement;multidisciplinary;Mutagenesis;mutant;Mutate;Mutation;NBS1 gene;Neutropenia;novel;Nuclear;nuclease;Oncogenic;Outcome;Pathologic;Pathway interactions;Pharmaceutical Preparations;Phosphorylation;Physical condensation;Point Mutation;polymerization;Polymers;Property;Protein Complex Subunit;protein protein interaction;Proteins;Public Health;Reaction;repaired;replication stress;Reporter;Research;response;Risk;RNA;RNA Binding;Role;Seminal;Source;superresolution microscopy;synergism;T-Cell Lymphoma;T-Lymphocyte;Testing;Therapeutic;Thrombocytopenia;tumor;Tumor Suppressor Proteins;Wiskott-Aldrich Syndrome;Wiskott-Aldrich syndrome protein;Work

PROJECT_TITLE: Maintenance of genome stability in 3D

STUDY_SECTION: MG

STUDY_SECTION_NAME: Molecular Genetics Study Section[MG]


NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: STANFORD

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE  Glaucoma is a leading cause of irreversible blindness associated with elevated intraocular pressure and increased glial cell reactivity that contribute to retinal ganglion cell (RGC) death. Here, using a newly developed model of ocular hypertension and novel viral vectors, we will test the role of compartmented signaling in astrocyte and Muller glial reactivity before, during, and after glaucoma onset, assaying for effects on RGC survival and microglial/macrophage infiltration, and explore the transcriptional and (epi)genomic mechanisms of neurotoxic and protective astrocyte reactivity.

PI_NAMEs: GOLDBERG, JEFFREY L (contact)

PROGRAM_OFFICER_NAME: HENLE, STEVEN JOHN

PROJECT_TERMS: Address;Adenylate Cyclase;Astrocytes;axon regeneration;Bicarbonates;Biological;Biological Assay;Biology;Blindness;Brain;Calcium;Cell Cycle;Cell Death;cell regeneration;Cell Survival;central nervous system injury;Cessation of life;Cyclic AMP;Cytoplasm;Data;Development;Disease;Elements;experimental study;Functional disorder;Gene Expression;Gene Expression Profile;Genetic;Genetic Transcription;Genomics;Glaucoma;glial activation;human disease;in vivo;Infiltration;inhibitor;Injury;Inner Plexiform Layer;insight;Knockout Mice;Link;Macrophage;Macrophage Activation;Mediating;Modeling;Molecular;Muller's cell;Mus;Mutation;Nerve Crush;Nerve Degeneration;neural repair;Neurodegenerative Disorders;Neuroglia;neuronal survival;Neurons;neuroprotection;neurotoxic;novel;novel strategies;Nuclear;Ocular Hypertension;Optic Disk;Optic Nerve;optic nerve disorder;Optic Nerve Injuries;Pathway interactions;Patients;Phenotype;Physiologic Intraocular Pressure;Play;Population;Porifera;Proliferating;Repression;response;Retina;Retinal Ganglion Cells;Role;Signal Transduction;single-cell RNA sequencing;Specificity;standard of care;Stress;Synapses;Testing;Time;Tissue-Specific Gene Expression;translational goal;Viral Vector;visual dysfunction;visual information;Work

PROJECT_TITLE: Compartmentalized cAMP signaling in reactive astrocytes

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 1 Study Section[PED1]


ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Narrative We plan to build on the successes of teplizumab in delaying the development of Type 1 diabetes and its approval as the first therapy for treating Type 1 diabetes since insulin. We aim to identify mechanisms of operational tolerance in responders to increase their frequency and duration of response.

PI_NAMEs: HEROLD, KEVAN C (contact)

PROGRAM_OFFICER_NAME: AKOLKAR, BEENA

PROJECT_TERMS: 2019-nCoV;Address;Affect;Aftercare;Age;Antibodies;antigen-specific T cells;Antigens;Autoantigens;Autoimmune Diseases;Autoimmunity;Back;Bar Codes;Beta Cell;biobank;CD3 Antigens;CD8-Positive T-Lymphocytes;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Characteristics;Clinical;clinical predictors;Clinical Trials;Combined Modality Therapy;Data;Development;Diabetes Mellitus;Diagnosis;Disease;Disease Progression;DNA;drug efficacy;early phase clinical trial;Environment;epigenome;exhaustion;Exhibits;experience;FDA approved;follow-up;Frequencies;Funding;Future;Goals;Grant;gut microbes;Human;Human Herpesvirus 4;Immune;Immune Tolerance;immunological status;Immunologics;Immunosuppression;Immunotherapy;Individual;Infection;Infusion procedures;Insulin;insulin dependent diabetes mellitus onset;Insulin-Dependent Diabetes Mellitus;Investigation;machine learning prediction;Membrane Proteins;Modeling;Monoclonal Antibodies;multiple omics;Pathogenesis;Pathogenicity;Pathologic Processes;Pathway interactions;Patient Selection;Patients;peripheral blood;Pharmaceutical Preparations;Pharmacotherapy;Phase;phase II trial;Phase III Clinical Trials;Phenotype;Population;predictive marker;predictive modeling;prevent;Prevention trial;Resolution;responders and non-responders;response;Risk;Sampling;Shapes;Signal Transduction;success;T-Lymphocyte;Techniques;Testing;therapy development;Time;transcriptome;Viral;Viral Antigens;Work

PROJECT_TITLE: Modulating pathogenic T cells in Type 1 diabetes

STUDY_SECTION: HAI

STUDY_SECTION_NAME: Hypersensitivity, Autoimmune, and Immune-mediated Diseases Study Section[HAI]


NIH_SPENDING_CATS: Antimicrobial Resistance;Bioengineering;Biomedical Imaging;Clinical Research;Clinical Trials and Supportive Activities;Infectious Diseases

ORG_CITY: SAN FRANCISCO

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE: This proposal describes a new approach to synthesize bacteria-targeted radiotracers for positron emission tomography (PET) via a one-step reaction using an enzyme and [18F]FDG, the most common tracer used in nuclear medicine. The simplicity of this method and wide availability of [18F]FDG suggest that numerous complex tracers can be made “on demand” in the acute care setting to better diagnose and treat infected patients.

PI_NAMEs: OHLIGER, MICHAEL ;WILSON, DAVID M (contact)

PROGRAM_OFFICER_NAME: RITCHIE, ALEC

PROJECT_TERMS: Acute;acute care;Affect;Antibiotic Therapy;ATP-Binding Cassette Transporters;Bacteria;Bacterial Infections;Binding Proteins;Clinical;clinical practice;clinical translation;Complex;Data;design;Detection;detection method;Diagnosis;Dimerization;Disaccharides;Discipline of Nuclear Medicine;Discitis;dosimetry;Engineering;Enzymes;Evaluation;Failure;first-in-human;Genes;Glucose;glucose 1 phosphate;Human;human disease;human pathogen;Imaging Device;Immobilization;improved;In Vitro;in vivo;Infection;Label;Laboratories;Link;Maltose;Mediating;Methicillin Resistance;Methods;Microbe;microorganism;Minor;Modeling;Mus;Musculoskeletal;novel strategies;Oligosaccharides;Osteomyelitis;Patients;Performance;permease;Phase;Phosphorylases;Polysaccharides;Positron;Positron-Emission Tomography;pre-clinical;Pre-Clinical Model;preclinical study;Preclinical Testing;Product Labeling;Production;radiotracer;Rattus;Reaction;Reporting;resistant strain;response;sensor;Serum;Signs and Symptoms;Solid;Spinal;spine bone structure;Staphylococcus aureus;Staphylococcus aureus infection;Sucrose;Techniques;Therapeutic;Time;tool;Toxic effect;Tracer;Translations;Trehalose;uptake;Work

PROJECT_TITLE: Chemoenzymatic radiosyntheses of [18F]FDG-derived oligosaccharides for S. aureus detection

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 ISB-P (03)]


ED_INST_TYPE: SCHOOLS OF NUTRITION

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Comparative Effectiveness Research;Cost Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Nutrition;Obesity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: BOSTON

ORG_NAME: TUFTS UNIVERSITY BOSTON

PHR: PROJECT NARRATIVE This project will address critical remaining questions around Food is Medicine programs (FIM), including assessing the health, equity, and cost impacts of varying FIM program design options, including key elements of dose ($/mo), food groups, duration, and disease targets; 2) assessing intersections of FIM with other levels of healthcare interventions including (a) coordinated food insecurity screening and SNAP enrollment, and (b) new clinical drug treatments; 3) investigating the administrative and legal feasibility of pathways for scaling FIM. This project also aims to disseminate top findings around FIM to relevant scientific, healthcare, legislative, agency, and advocacy stakeholders.

PI_NAMEs: MOZAFFARIAN, DARIUSH  (contact)

PROGRAM_OFFICER_NAME: PRATT, CHARLOTTE A

PROJECT_TERMS: Acceleration;Accreditation;Address;Adult;Advocacy;advocacy organizations;Agonist;authority;black patient;Blood Pressure;Body mass index;Cardiometabolic Disease;cardiometabolism;care providers;Caring;Clinical;clinical care;Communication;comparative;cost;cost effectiveness;Cost Effectiveness Analysis;cost outcomes;Cost Savings;design;Diabetes Mellitus;Diet;dietary;Dietary Intervention;Disease;Disparity;Dose;E-learning;economic incentive;Education;Elements;Enrollment;Equity;ethnic minority;Ethnic Origin;Etiology;experimental study;Food;Food Assistance Programs;food insecurity;Food Labeling;Food Policy;food security;Food Services;Formulation;Foundations;glucagon-like peptide 1;Government;Government Officials;Health;health assessment;Health Care Sector;health disparity;health equity;Health Food;Health Insurance;Health Status;Health system;Healthcare;Healthcare Systems;Hispanic;Hunger;improved;incentive program;Income;interest;Intervention;Joints;Label;Learning;Legal;Low income;marginalized population;Mass Media;Measures;Medicaid;Medical;Medical Care Costs;Medical Education;Medicare/Medicaid;Medicine;Modeling;models and simulation;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutics;nutrition;Obesity;outcome disparities;Overweight;Pathway interactions;Patient Self-Report;Patients;Pharmacotherapy;Physicians;Policies;Policy Analysis;Population;Prediabetes syndrome;Private Sector;Privatization;Productivity;programs;Progress Reports;Provider;Qualitative Research;Quality-Adjusted Life Years;Quasi-experiment;Race;racial minority;randomized, clinical trials;Reduce health disparities;Research;Research Methodology;Risk;Schools;screening;Security;social culture;social health determinants;Societies;Sodium Chloride;soft drink;sugar;Surveys;System;Taxes;Teenagers;Training;Uncertainty;United States Department of Veterans Affairs;United States Indian Health Service;United States National Institutes of Health;waiver;Wellness Program;Work

PROJECT_TITLE: Cost-Effectiveness of Food is Medicine Interventions to Improve Diet and Reduce Cardiometabolic Diseases

STUDY_SECTION: HSQE

STUDY_SECTION_NAME: Health Services: Quality and Effectiveness Study Section[HSQE]


ORG_CITY: LA JOLLA

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative. Microbial derived non-ribosomal peptide and polyketide secondary metabolites play critical roles in the clinic, and their biosynthetic pathways hold great promise for development of new therapeutic molecules. However, we still lack a full understanding of the molecular mechanisms responsible for non- ribosomal peptide and polyketide secondary metabolites biosynthesis, particularly related to the role of protein- protein interactions in directing biosynthesis. Leveraging an advanced series of molecular traps, our team combines structural biology with novel state-locking methods to explore the discrete interactions, dynamics, reactivities and catalytic mechanisms that enable natural product production and use them to enable synthetic biology.

PI_NAMEs: BURKART, MICHAEL D. (contact)

PROGRAM_OFFICER_NAME: BOND, MICHELLE RUEFFER

PROJECT_TERMS: Active Sites;Acyl Carrier Protein;Address;Alkylation;Anabolism;analog;anti-fungal agents;Anti-Inflammatory Agents;Antiparasitic Agents;Berry;Binding;Biological;Biological Models;Biology;Biomanufacturing;Book Chapters;Carrier Proteins;Catalytic Domain;Chemicals;Chemistry;Clinic;clinically relevant;Communicable Diseases;Complex;Computer Models;cooking;Coupled;Coupling;crosslink;Crosslinker;Cryoelectron Microscopy;Cyclization;Data;design;Development;direct application;Docking;Engineering;Enzymes;Evolution;Funding;Future;Genetic;Goals;Hybrids;Immunosuppression;in silico;In Situ;In Vitro;Individual;Maps;Mechanics;metabolic engineering;Metabolic Pathway;Methodology;Methods;microbial;Modification;Molecular;molecular modeling;Mutagenesis;Natural Products;Nature;NMR Spectroscopy;novel;novel therapeutics;Oxazoles;particle;Pathway interactions;peptide synthase;Peptides;Pharmaceutical Preparations;Physical condensation;Play;polyketide synthase;polyketides;Preparation;Production;programs;Progress Reports;protein crosslink;Protein Engineering;protein protein interaction;Proteins;Publications;Publishing;Pyrroles;rational design;Regulation;Research;Role;secondary metabolite;Series;simulation;Site;Source;Specificity;structural biology;Structure;synthetic biology;System;Technology;Tertiary Protein Structure;Testing;Therapeutic;tool;X-Ray Crystallography

PROJECT_TITLE: Protein-protein interactions in natural product biosynthesis

STUDY_SECTION: MSFA

STUDY_SECTION_NAME: Macromolecular Structure and Function A Study Section[MSFA]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Disability Research;Machine Learning and Artificial Intelligence;Mental Health;Neurosciences;Pediatric

ORG_CITY: STORRS-MANSFIELD

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF CONNECTICUT STORRS

PHR: Project Narrative This project is motivated by two significant overarching issues: 1) Across children with reading disability there is substantial variability in pre-to-post intervention gains in reading, with many children showing minimal improvement; and 2) Despite substantial efforts, factors that might explain these variable outcomes remain elusive and prediction at the individual level is not yet possible. Through Community Engaged Research (CER), this project will utilize a novel in-school cognitive neuroscience approach and state-of-the-art analytic methods to establish trajectories of response to intervention among RD readers and identify reliable, generalizable predictors of response.

PI_NAMEs: LANDI, NICOLE  (contact)

PROGRAM_OFFICER_NAME: MILLER, BRETT

PROJECT_TERMS: Academic achievement;Accounting;advanced analytics;Affect;analytical method;Attention deficit hyperactivity disorder;behavior measurement;Behavioral;brain behavior;Child;cognitive ability;cognitive neuroscience;cohort;community engaged research;comorbidity;Data;Data Collection;design;Development;disability;disabled students;dosage;educational atmosphere;Educational Curriculum;Electroencephalography;Environment;evidence base;Evidence based intervention;Grain;Growth;improved;Individual;Individual Differences;Instruction;Intervention;Knowledge;Laboratories;Language;Language Development Disorders;Learning;Learning Disabilities;Letters;Machine Learning;machine learning model;Mainstreaming;Measures;Modeling;Names;neural;Neurobiology;Neurocognitive;Neurodevelopmental Disorder;novel;Oral;Orthography;Outcome;Personal Satisfaction;phonological awareness;phonology;Population;post intervention;predicting response;Predictive Factor;predictive modeling;Printing;Privatization;Process Measure;Reader;Reading;reading difficulties;Reading Disabilities;Research;response;Sampling;Schools;Science;Semantics;skills;sound;Speech;Speech Perception;spelling;Standardization;standardize measure;Students;System;Testing;theories;Time;treatment response;Vocabulary;Well in self;Work;Writing

PROJECT_TITLE: Predicting Intervention Outcomes in Reading Disabled Students Using In-School Cognitive Neuroscience

STUDY_SECTION: LCOM

STUDY_SECTION_NAME: Language and Communication Study Section[LCOM]


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: BELTSVILLE

ORG_NAME: PACIFIC INSTITUTE FOR RES AND EVALUATION

ORG_STATE: MD

PHR: Project Narrative Compared to their cisgender peers, Transgender or Gender Diverse (TGD) people—individuals with gender identities that differ from their sex assigned at birth—are impacted by an extraordinarily high prevalence of negative mental and physical health outcomes and have major unmet social needs due to structural factors, including systematic societal, political, and economic marginalization, medical pathologization, and violence. Using a structural competency framework that considers the external forces shaping health outcomes at levels above individual interaction, this study will implement and evaluate a TGD-specific adaptation of the Critical Time Intervention (CTI), an evidence-based case management program, for TGD people, and develop implementation strategies to facilitate its uptake in under-resourced health and human service systems. This theory-driven, mixed-methods research will produce data targeting the structural factors responsible for the well-documented access barriers and excessive morbidity and mortality faced by TGD people.

PI_NAMEs: WILLGING, CATHLEEN E. (contact)

PROGRAM_OFFICER_NAME: FREEMAN, WILLIAM

PROJECT_TITLE: Implementing Structurally Competent Critical Time Intervention for Transgender and Gender-Diverse Patients

STUDY_SECTION: HEOR

STUDY_SECTION_NAME: Healthcare Effectiveness and Outcomes Research[HEOR]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Human Genome;Patient Safety;Prevention

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

PHR: PROJECT NARRATIVE Although genetic information provides an opportunity to personalize clinical care, it is not widely used in practice. We will build a system to make genetic information a routine part of clinical medicine, working in partnership with doctors and patients to learn and share strategies that work best.

PI_NAMEs: BICK, ALEXANDER ;KRIPALANI, SUNIL ;RODEN, DAN M (contact)

PROGRAM_OFFICER_NAME: ROWLEY, ROBB KENNETH

PROJECT_TERMS: Academic Medical Centers;Adoption;Adult;cancer genomics;cancer predisposition;Cardiovascular Diseases;care delivery;Clinic;Clinical;clinical care;clinical decision support;Clinical Informatics;Clinical Medicine;clinical practice;clinical research site;Clinics and Hospitals;Collaborations;Critical Illness;Data;Diagnostic;Discipline;Disease;disease-causing mutation;disorder risk;education resources;effectiveness evaluation;Electronic Health Record;Ensure;Environment;Equity;Family health status;Family history of;Frequencies;Genetic;Genetic Diseases;genetic information;Genetic Risk;genetic testing;genome sciences;genomic data;Genomic medicine;Genomics;Goals;Health system;Healthcare;Hereditary Disease;human disease;implementation evaluation;implementation science;implementation strategy;in silico;Individual;Informatics;Infrastructure;innovation;Institution;Intervention;Knowledge;Laboratories;Lead;Leadership;Learning;Link;Mendelian disorder;Methods;National Human Genome Research Institute;neonate;Outcome;Patient Education;Patients;pediatric patients;personalized genomics;Pharmacogenomics;Phenotype;point of care;Population;portability;Positioning Attribute;practice setting;precision oncology;preempt;prevent;Productivity;Protocols documentation;randomized controlled design;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;Recording of previous events;Reference Values;Research;Research Personnel;Resource Sharing;Resources;Site;support network;support tools;System;Testing;tool;Translations;Underserved Population;Universities;uptake;Work

PROJECT_TITLE: Vanderbilt Genomic Learning Health System Clinical Site

STUDY_SECTION_NAME: Special Emphasis Panel[ZHG1 HGR-W (M1)]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Immunotherapy;Prevention;Skin Cancer

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: NARRATIVE A major problem in treating human cancer is development of resistance to therapy that occurs following most treatments including radiation, chemo-, targeted, and immuno-therapies. We will use our novel analytical tools to compare how drug resistance develops at the single cell level in human cancer and in chemically induced mouse cancer by studying thousands of individual malignant cells at molecular resolution. This may ultimately lead to biomarkers of cancer drug resistance or targets to prevent development of drug resistance.

PI_NAMEs: AKHURST, ROSEMARY J (contact);BALMAIN, ALLAN

PROGRAM_OFFICER_NAME: BERA, TAPAN K

PROJECT_TERMS: Acetates;Adjuvant;Aftercare;analytical tool;anti-PD-1;Antineoplastic Agents;Benchmarking;biocomputing;Biological Markers;Biology;biomarker discovery;Biometry;Bladder;cancer biomarkers;Cancer Burden;cancer cell;cancer drug resistance;cancer therapy;Candidate Disease Gene;Carcinogens;Carcinoma;Cells;Cessation of life;chemical carcinogenesis;Chemicals;chemotherapy;Cisplatin;Clinical Oncology;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;combinatorial;comparative;Complex;Computing Methodologies;Credentialing;CRISPR interference;Data;data sharing;Databases;Development;digital;dimethylbenzanthracene;Distant;drug development;Drug resistance;drug resistance development;Drug Targeting;Elements;Environment;Esophagus;Exposure to;Gene Targeting;Genes;Genetic;Genetic Transcription;genome-wide;Genomics;Goals;Head and neck structure;House mice;Human;Immune;Immunotherapeutic agent;Immunotherapy;In Situ;in vivo;in vivo Model;Individual;knock-down;Knowledge;Lung;Malignant Neoplasms;Metastasis Induction;Methods;Modeling;Molecular;mouse model;Mus;Mutagenesis;Mutagens;Mutation;nano-string;Neoadjuvant Therapy;Neoplasm Metastasis;neoplastic cell;new technology;notch protein;novel;novel strategies;Oncogenic;Oncology;Operative Surgical Procedures;Papilloma;Pathway interactions;Pharmaceutical Preparations;Pharmacotherapy;Phorbols;PIK3CG gene;Play;Population;prevent;Prevention;Process;Protocols documentation;Radiation;Radiation therapy;Resected;Resistance development;Resolution;response;Role;Sampling;Signal Pathway;single cell analysis;single-cell RNA sequencing;Site;Skin;skin squamous cell carcinoma;Solid Neoplasm;spatial relationship;Squamous cell carcinoma;standard of care;stem cells;Structure;System;Technology;Testing;Therapeutic;therapeutic target;therapy resistant;Tissues;tool;transcriptomics;treatment response;tumor;tumor initiation;Tumor Promotion;validation studies;Work

PROJECT_TITLE: A network approach to interrogate cellular plasticity and drug resistance in cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CTH-D (55)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Pediatric

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Project Narrative Executive functions, the goal-directed processes that support flexible adaptation of behavior in response to changing circumstances, develop dramatically during childhood, predict important life outcomes, and are impaired in many clinical disorders. Many studies and intervention attempts have focused on children’s capacity to engage executive functions, but children adaptively coordinate whether or not to engage executive functions based on a variety of factors beyond capacity, and these choices shape future engagement of executive functions. This project thus investigates how executive functions are adaptively coordinated across development to match environmental demands, how these adaptations can be harnessed during sensitive time periods to develop effective interventions, and how these adaptations lead to cascading effects that are important to healthy development.

PI_NAMEs: MUNAKATA, YUKO  (contact)

PROGRAM_OFFICER_NAME: MACHLIN, LAURA STONER

PROJECT_TERMS: Academic achievement;Adaptive Behaviors;Address;Adolescence;Adult;Age;Attention deficit hyperactivity disorder;autism spectrum disorder;Basic Science;Behavior;Behavioral;Child;Child Behavior;Child Support;Childhood;Clinical;Cognition;Cognitive;Complex;contextual factors;Costs and Benefits;Development;Disease;early experience;effective intervention;Electroencephalography;Emotional;Environment;executive function;experience;flexibility;Foundations;Future;Goals;Habits;Health;Impairment;improved;Individual;Individual Differences;Intervention;Lead;Learning;learning ability;Life;Link;longitudinal dataset;Measures;Mental Depression;neural;neurophysiology;Outcome;Parents;Performance;Problem behavior;Process;Psyche structure;Psychological reinforcement;Questionnaires;Reporting;response;Retrieval;scaffold;Schizophrenia;Series;Shapes;social norm;support network;Testing;theories;Time;Variant;Work

PROJECT_TITLE: Developing Adaptive Coordination of Executive Functions

STUDY_SECTION: HCMF

STUDY_SECTION_NAME: Human Complex Mental Function Study Section[HCMF]


NIH_SPENDING_CATS: Atherosclerosis;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Physical Activity

ORG_CITY: LOUISVILLE

ORG_NAME: UNIVERSITY OF LOUISVILLE

ORG_STATE: KY

PHR: Abstract A food supplement carnosine can improve the walking ability of patients having leg ischemia.

PI_NAMEs: BABA, SHAHID P (contact);BHATNAGAR, ARUNI ;DWIVEDI, AMIT J

PROGRAM_OFFICER_NAME: REID, DIANE M

PROJECT_TERMS: Aerobic;Affect;Aftercare;Aldehydes;American;angiogenesis;Ankle;Arterial Fatty Streak;Arterial Occlusive Diseases;Arteries;Atherosclerosis;ATP Synthesis Pathway;Attenuated;Binding;Biopsy;Blood flow;blood perfusion;Buffers;Cardiac;cardiovascular disorder risk;Carnosine;Cell Therapy;chelation;Chronic;claudication;clinical efficacy;Clinical Management;Clinical Trials;cost;Data;Defect;design;Dipeptides;Double-Blind Method;Effectiveness;efficacy testing;Enrollment;Enzymes;Excision;Excretory function;Exercise;exercise capacity;FDA approved;feeding;Female;Fibrosis;follow-up;Food Supplements;Foundations;Functional disorder;Glucose;Goals;Growth;hemodynamics;Hindlimb;Histidine;Impairment;improved;indexing;Intermittent Claudication;Intervention;Ischemia;Isolated limb perfusion;Laboratories;Leg;limb loss;Limb structure;Lipid Peroxidation;Lower Extremity;Magnetic Resonance Imaging;Magnetic Resonance Spectroscopy;male;Measures;Mediating;Medical;Metabolic;Metabolic dysfunction;Metabolism;metabolomics;Metals;Mitochondria;Morbidity - disease rate;mortality;Mus;Muscle;Muscle function;muscle physiology;novel;Obstruction;Operative Surgical Procedures;Outcome Study;Participant;Pathway interactions;Patients;Performance;Perfusion;Peripheral arterial disease;Persons;Pharmacotherapy;Phase III Clinical Trials;Placebos;pre-clinical;prevent;primary outcome;Process;Property;protein expression;Proteomics;Quality of life;Randomized;Reperfusion Injury;Rest;revascularization surgery;Risk Factors;Role;secondary outcome;Secondary to;Skeletal Muscle;skeletal muscle metabolism;standard of care;Stenosis;Stents;success;Supplementation;Testing;Therapeutic;Therapeutic Intervention;Time;Tissues;Transition Elements;treadmill;urinary;Walking;walking performance;β-Alanine

PROJECT_TITLE: Role of carnosine in peripheral arterial disease

STUDY_SECTION: CCHS

STUDY_SECTION_NAME: Clinical Integrative Cardiovascular and Hematological Sciences Study Section[CCHS]


NIH_SPENDING_CATS: Contraception/Reproduction;Estrogen;Fibroid Tumors (Uterine);Genetics;Women's Health Research

ORG_CITY: KANSAS CITY

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: Project Narrative Functional loss of the repressor protein REST in the myometrium leads to aberrant expression of its target genes and altered ovarian steroid hormone response in UL. Similarly, widespread occurrence of MED12 mutation promotes UL pathogenesis dependent on estrogen – progesterone receptor pathways. The project will establish a mechanistic relationship between the loss of REST, MED12 mutation and altered hormone sensitivity in uterine fibroids using in vitro methods and novel in vivo models.

PI_NAMEs: CHENNATHUKUZHI, VARGHEESE MANI (contact);RAJKOVIC, ALEKSANDAR

PROGRAM_OFFICER_NAME: ALLEN, CATHERINE LEIGH

PROJECT_TERMS: 3-Dimensional;Ablation;Accounting;Age;Benign;Binding;Chromatin;Clinical;Collagen;Complex;Computer Analysis;conditional knockout;cost;Data;Data Set;Development;Epigenetic Process;epigenetic regulation;epigenome;epigenomics;ESR1 gene;Estrogen Receptor Modulators;Estrogens;experimental study;Fibroid Tumor;functional loss;Future;Gene Expression;Gene Expression Profile;Gene Expression Regulation;Gene Modified;Genes;Genetic Models;Genomic Instability;Goals;Growth;Hi-C;histone methyltransferase;hormone regulation;hormone sensitivity;Hormones;Human;Hysterectomy;In Vitro;in vivo Model;Investigation;Laboratories;Lead;Leiomyoma;Malignant Breast Neoplasm;Mediator;medication safety;Methods;Missense Mutation;Modeling;Molecular;Molecular Target;Morbidity - disease rate;mouse model;Mus;mutant;mutant mouse model;Mutate;Mutation;myometrium;neoplastic cell;novel;Ovarian Steroid Hormone;Pathogenesis;Pathway interactions;Pelvic Neoplasms;Pharmaceutical Preparations;Pharmacotherapy;Phenotype;Pre-Clinical Model;premature;Progesterone;Progesterone Receptors;racial disparity;receptor;receptor function;recruit;Regulation;Regulatory Element;Reporting;Repressor Proteins;reproductive;Research;response;Rest;Role;Safety;Signal Transduction;Smooth Muscle Myocytes;steroid hormone;Steroids;Symptoms;therapy development;Tissue Sample;Tissues;transcriptomics;tumor;Tumor Suppressor Proteins;tumorigenesis;United States;Uterine Fibroids;Uterus;Variant;Woman

PROJECT_TITLE: REST-MED12 Pathways in the Regulation of Estrogen - Progesterone Sensitivity in Uterine Leiomyoma

STUDY_SECTION: ICER

STUDY_SECTION_NAME: Integrative and Clinical Endocrinology and Reproduction Study Section[ICER]


NIH_SPENDING_CATS: Clinical Research;Digestive Diseases;Neurodegenerative;Neurosciences;Nutrition;Obesity;Peripheral Neuropathy;Prevention

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

PHR: PROJECT NARRATIVE Degeneration of enteric neurons can lead to intestinal motility disorders as seen in diabetes, aging, slow transit constipation, Hirschsprung’s disease and Western diet intake. In this proposal, using our model of Western diet induced neuronal loss, we will examine the mechanism of how saturated fatty acids lead to damage of enteric neurons with a focus on the role of iron and mitochondrial dysfucntion. Experiments outlined in this proposal may also lead to new therapeutic targets for treating the altered gastrointestinal motility in humans with a Western diet intake as well as in aging and diseases such as diabetes and slow transit constipation.

PI_NAMEs: SRINIVASAN, SHANTHI K (contact)

PROGRAM_OFFICER_NAME: SHEA-DONOHUE, TEREZ

PROJECT_TERMS: Aging;Antioxidants;Cell Line;Cells;Cessation of life;Clinical;clinically relevant;Colon;colon surgery;Congenital Megacolon;Constipation;Data;Diabetes Mellitus;Diet;Disease;Enteral;Enteric Nervous System;enteric neuropathy;Epithelial Cells;experimental study;Exposure to;Fatty acid glycerol esters;feeding;Ferritin;Functional disorder;Ganglia;Gastrointestinal Motility;Generations;Goals;High Fat Diet;Homeostasis;Human;Impairment;In Vitro;in vivo;Induced Neurons;inhibitor;Injury;Intake;Intestinal Motility;Intestines;Investigation;Iron;Iron Chelation;Iron Overload;knock-down;Laboratory Study;Lead;Lipid Peroxidation;Mediating;Membrane Lipids;Mitochondria;mitochondrial dysfunction;Modeling;Motility;motility disorder;mouse model;Mus;Nerve Degeneration;neural network;neuron loss;Neurons;new therapeutic target;novel;Obese Mice;obese patients;obese person;Obesity;overexpression;Overweight;oxidation;Palmitates;Pathway interactions;Predisposition;preservation;prevent;Production;Reactive Oxygen Species;Respiration;Role;Sampling;Saturated Fatty Acids;SLC11A2 gene;Small Interfering RNA;Stress;Structure;targeted treatment;Testing;Thinness;uptake;western diet

PROJECT_TITLE: Mechanism of Enteric Neuropathy

STUDY_SECTION: DNPD

STUDY_SECTION_NAME: Digestive and Nutrient Physiology and Diseases Study Section [DNPD]