NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences;Prevention;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Alzheimer's disease (AD) is a progressive neurodegenerative disease and the leading cause of dementia with high heritability. Although recent genome-wide association studies (GWAS) of AD have identified more than 20 risk loci, the genetic etiology of AD leading to molecular and cellular pathology remains largely unknown. By combining human induced pluripotent stem cells (hiPSCs) with gene editing and comprehensive multi-omics and cellular analyses, our investigation will reveal the cell type-specific effects of AD genetic risk variants on AD pathogenesis, which may advance our understanding of genetic architecture of AD and disease etiology, and lead to therapeutic advances.

PI_NAMEs: LI, BINGSHAN ;WEN, ZHEXING  (contact)

PROGRAM_OFFICER_NAME: GRAY, ERIN EMILY

PROJECT_TERMS: Abeta synthesis;Address;Affect;Alzheimer like pathology;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease risk;Astrocytes;ATAC-seq;Biological Process;biological systems;Brain;brain tissue;causal variant;Cell Death;Cell Physiology;cell type;Cells;cellular pathology;Chromatin;Chromatin Conformation Capture and Sequencing;Clustered Regularly Interspaced Short Palindromic Repeats;Coculture Techniques;Complex;Data;Dementia;Dendrites;design;Development;Disease;disorder risk;Dissection;Distal;DNA;DNA Methylation;Epigenetic Process;epigenomics;Etiology;Gene Expression;Genes;Genetic;genetic architecture;Genetic Heterogeneity;Genetic Predisposition to Disease;Genetic Risk;Genetic study;Genetic Transcription;Genome;genome wide association study;Genomics;Goals;Heritability;Heterogeneity;histone modification;Human;Human body;Human Genome;human induced pluripotent stem cells;indexing;induced pluripotent stem cell;Induced pluripotent stem cell derived human neuron;insight;Investigation;Lead;Link;Linkage Disequilibrium Mapping;Machine Learning;machine learning method;Maps;Microglia;Modeling;molecular pathology;Morphology;multi-ethnic;multiple omics;Nature;Neurodegenerative Disorders;neuroinflammation;Neurons;novel therapeutic intervention;Oxidative Stress;Pathogenesis;Pathway interactions;Play;Regulation;Reporting;Research;risk variant;Role;Synapses;synaptic function;tau aggregation;tau-1;Testing;Therapeutic;trait;transcriptome sequencing;transcriptomics;United States;Untranslated RNA;Variant;virtual

PROJECT_TITLE: Towards a better understanding of genetic architecture of Alzheimer's disease with human iPSC models

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


ADMINISTERING_IC: DK

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Clinical Research;Digestive Diseases;Genetics;Human Genome;Inflammatory Bowel Disease;Microbiome

ORG_CITY: NEW YORK

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: Project Narrative All living cells use carbohydrates and carbohydrate binding proteins (e.g. lectins) to interact with its environment but despite the importance of lectins to human pathophysiology and for therapeutic development, the study of lectins made by bacteria that live inside humans (i.e. commensal bacteria) has been limited. In this proposal we will (1) study how a lectin made by a commensal bacteria regulates intestinal immune cells, (2) explore the therapeutic potential of this lectin to treat inflammatory bowel disease and (3) begin mapping the network of host- microbe interactions mediated by lectins produced by human commensal bacteria. These aims will improve our understanding of how the human microbiome contributes to disease and develop novel therapeutic strategies.

PI_NAMEs: COHEN, LOUIS JARED (contact)

PROGRAM_OFFICER_NAME: LUNSFORD, DWAYNE

PROJECT_TERMS: Architecture;Bacteria;Binding;Bioinformatics;Biological Response Modifier Therapy;carbohydrate binding protein;carbohydrate receptor;Carbohydrates;Cell Communication;Cell Separation;Cells;cellular targeting;Clinical Trials;Colitis;Collaborations;commensal bacteria;commensal microbes;Complex;Data;Data Set;Dendritic Cells;dextran sulfate sodium induced colitis;Disease;effective therapy;Engineering;Environment;experimental study;Functional disorder;functional genomics;Future;Gene Family;Genes;Gnotobiotic;Grant;gut microbiota;Health;Homeostasis;host-microbe interactions;Human;Human Microbiome;human microbiota;Immune;improved;Inflammatory Bowel Diseases;intestinal homeostasis;Intestines;Laboratories;Lectin;Length;Libraries;Ligands;Macrophage;Maintenance;Maps;Mediating;microbial;microbiome;microbiome sequencing;microbiota;monocyte;mouse model;Mucous Membrane;murine colitis;Mus;Myeloid Cells;New York;novel therapeutic intervention;novel therapeutics;Patients;Pattern recognition receptor;Peripheral Blood Mononuclear Cell;Persons;Polysaccharides;Population;pre-clinical;protein complex;Proteins;Regulation;Research;Research Methodology;Resources;response;Role;screening;Severities;Signal Transduction;single-cell RNA sequencing;Site;Specificity;structural biology;Target Populations;Testing;Therapeutic;therapeutic development;trafficking

PROJECT_TITLE: Characterization of lectins to understand human microbiome functions and develop live biotherapeutics

STUDY_SECTION: DHMI

STUDY_SECTION_NAME: Digestive System Host Defense, Microbial Interactions and Immune and Inflammatory Disease Study Section[DHMI]


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Digestive Diseases - (Peptic Ulcer);Infectious Diseases;Rare Diseases;Stomach Cancer

ORG_CITY: LOS ANGELES

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: Project Narrative  Helicobacter pylori infect the gastric mucosa of 50% of the world’s population, leading to gastritis and, in some, gastric or duodenal ulcers or cancer. The proposed study will investigate how H. pylori injure the stomach lining. The results from this study will aid in understanding why and how some people develop advanced disease, including ulcers and cancer, and will help in the development of new treatment regimens or gastric protective measures.

PI_NAMEs: MARCUS, ELIZABETH A. (contact)

PROGRAM_OFFICER_NAME: GREENWEL, PATRICIA

PROJECT_TERMS: Acceleration;acute infection;Adhesions;advanced disease;Affect;Antibiotic Resistance;Atrophic;Bacteria;Bacterial Attachment Site;Cancer Etiology;career;Caring;Cell Adhesion Molecules;Cell membrane;Cell Physiology;Cells;Cessation of life;Childhood;chronic infection;Clinical;Coculture Techniques;Critical Pathways;Data;Dependence;Development;Disease;Down-Regulation;Duodenal Ulcer;Epithelial Cells;epithelial injury;Epithelium;Faculty;Fortification;Functional disorder;Gastric Adenocarcinoma;Gastric mucosa;Gastric ulcer;Gastritis;Gastroenterologist;Gastrointestinal Diseases;Genes;Goals;Helicobacter Infections;Helicobacter pylori;Homeostasis;Impairment;improved;In Vitro;in vivo;Infection;Injections;Injury;innovation;insight;Integration Host Factors;Ions;Knowledge;Malignant Neoplasms;malignant stomach neoplasm;Measures;Mediating;Membrane Potentials;Modeling;Molecular Chaperones;mucosa-associated lymphoid tissue lymphoma;Mucous Membrane;nano-string;novel;novel therapeutics;Outcome;pathogen;Pathology;Pathway interactions;Persons;Phosphotransferases;Physicians;Physiological;Play;Population;Post-Translational Protein Processing;prevent;Prevention;Proteins;Pump;Research;Research Proposals;Role;Scientist;Signal Induction;Signal Pathway;Signal Transduction;Sodium;Stomach;Stomach Carcinoma;System;Techniques;trafficking;Treatment Protocols;tumorigenesis;Type IV Secretion System Pathway;Ulcer;Work

PROJECT_TITLE: Mechanisms of induction of gastric injury by H. pylori

STUDY_SECTION: GMPB

STUDY_SECTION_NAME: Gastrointestinal Mucosal Pathobiology Study Section[GMPB]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Cerebrovascular;Childhood Injury;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Stroke;Unintentional Childhood Injury

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Project Narrative This proposal focuses on recently discovered cellular and molecular mechanisms of disrupted regeneration and repair of neonatal white matter injury that are mediated by formation of a “glial scar” that serves as a barrier to prevent the normal myelination of the preterm developing human brain after hypoxia-ischemia. We will employ molecular and histopathological approaches to define a novel molecular pathway that initiates formation of the glial scar. We will test new potential therapies to block glial scar formation and promote enhanced myelination of chronic white matter lesions in the hope of reducing the life-long burden of cerebral palsy in preterm survivors.

PI_NAMEs: BACK, STEPHEN ARTHUR (contact)

PROGRAM_OFFICER_NAME: DOPERALSKI, ADELE ELIZABETH

PROJECT_TERMS: Adult;Animal Model;astrocyte progenitor;Astrocytes;astrogliosis;Attention;Attenuated;Blocking Antibodies;Brain;Brain Hypoxia-Ischemia;central nervous system injury;Cerebral Palsy;Cerebrum;Childhood;Chronic;Cicatrix;Clinical Trials;Cognitive;connectome;Diagnosis;Diffuse;disability;Disease;Enzymes;Event;Extracellular Matrix;Failure;Future;Generations;Genes;Human;Hyaluronic Acid;Hyaluronidase;hypoxic ischemic injury;In Vitro;in vivo;inhibiting antibody;inhibitor;insight;inter-alpha-inhibitor;kinase inhibitor;Learning;Lesion;Life;Mediating;Memory;Modeling;Molecular;Motor;myelination;Natural regeneration;Neonatal;Nervous System Disorder;neurobehavioral;neuropsychiatric disorder;novel;novel strategies;novel therapeutic intervention;novel therapeutics;oligodendrocyte progenitor;Pathway interactions;Perinatal Hypoxia;Phase;Premature Birth;preterm newborn;prevent;progenitor;Proliferating;protein complex;Protein Subunits;Proteins;Reaction;repaired;response;Risk;Rodent;Role;Signal Transduction;Socialization;src-Family Kinases;Survivors;Testing;Therapeutic;Time;TNF gene;Tumor Necrosis Factor Activation;Vertebral column;white matter;white matter injury

PROJECT_TITLE: White matter protection by inhibitors of glial scar formation in perinatal hypoxia ischemia

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


NIH_SPENDING_CATS: Brain Disorders;Epilepsy;Neurodegenerative;Neurosciences;Orphan Drug;Pediatric;Rare Diseases

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: T-type calcium channels (T-channels) play an important role in controlling neuronal excitability. Pro-excitatory changes in T-channels have been reported in absence epilepsy and temporal lobe epilepsy (TLE). A better understanding for the role of CACHD1 in facilitating increases in T- channel activity and the development of absence epilepsy and TLE will lead to novel targeted therapies for this disorder.

PI_NAMEs: PATEL, MANOJ K (contact)

PROGRAM_OFFICER_NAME: LEENDERS, MIRIAM

PROJECT_TERMS: Absence Epilepsy;Action Potentials;Affect;American;Animal Model;anti-epileptic agents;Anticonvulsants;Aspartic Acid;Awareness;Brain region;butyrolactone;Calcium Channel;Cell surface;Characteristics;Chemotaxis;Development;Diagnosis;Disease;Economics;Epilepsy;Equilibrium;Event;Extracellular Domain;Fire - disasters;Foundations;Frequencies;gain of function;Generations;Hippocampus;Human;knock-down;Knock-out;Knockout Mice;Link;loss of function;Membrane Potentials;Modeling;mouse model;Mus;neuronal excitability;Neurons;new therapeutic target;novel;novel therapeutic intervention;Pacemakers;Patients;Pattern;Pharmaceutical Preparations;Play;Population;Predisposition;prevent;protein expression;Proteins;receptor;Reporting;Rest;Rodent;Role;Seizures;Severities;side effect;Signal Transduction;Site;Sodium;T-Type Calcium Channels;Temporal Lobe Epilepsy;Testing;Thalamic structure;therapy development;trafficking;Tyrosine;Unconscious State;Up-Regulation

PROJECT_TITLE: Role of CACHD1 in the development of temporal lobe epilepsy and absence epilepsy

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Networking and Information Technology R&D (NITRD);Neurosciences;Radiation Oncology;Rare Diseases

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

PHR: Spectroscopic MRI provides increased sensitivity and specificity for detection of brain tumors relative to conventional MRI by measuring differences in metabolism between aggressive brain tumor and normal brain tissues. Our 3-site pilot study using spectroscopic MRI to guide radiation dose escalation not only demonstrated feasibility and safety, but also showed potential for significant improvement in clinical outcomes for patients diagnosed with glioblastoma (GBM). This project will increase the performance of spectroscopic MRI to improve image quality and reliability, to reduce acquisition and processing times, and will facilitate clinical adoption of this technology.

PI_NAMEs: COOPER, LEE ;MELLON, ERIC ALBERT;SHIM, HYUNSUK  (contact)

PROGRAM_OFFICER_NAME: ZHANG, HUIMING

PROJECT_TERMS: 3-Dimensional;Acceleration;Adoption;Adult;American College of Radiology;American College of Radiology Imaging Network;Area;Award;Back;Brain;Brain Neoplasms;brain tissue;Chemotherapy and/or radiation;Choline;Clinical;clinical decision-making;clinical imaging;clinical implementation;Clinical Trials;Clinical Trials Cooperative Group;cloud based;Collaborations;contrast enhanced;Data;data analysis pipeline;Data Display;data management;data visualization;Detection;detection method;Development;Diagnosis;Diagnostic;Disease Progression;Dose;Eastern Cooperative Oncology Group;Engineering;Environment;Excision;follow-up;Friends;Funding;Genomics;Glioblastoma;Goals;Grant;Head;high risk;Histologic;Hour;Image;image reconstruction;imaging modality;imaging platform;Imaging technology;improved;improved outcome;Infiltration;Left;Life;Lipids;Magnetic Resonance Imaging;magnetic resonance spectroscopic imaging;Maps;Measures;Metabolic;metabolic imaging;Metabolism;Methods;Morphologic artifacts;Motion;multidimensional data;Multimodal Imaging;N-acetylaspartate;National Clinical Trials Network;Nature;neoplastic cell;neovasculature;Network-based;neural network;Newly Diagnosed;novel;Operative Surgical Procedures;Outcome;Patient-Focused Outcomes;Patients;Performance;Phase;Physicians;Pilot Projects;predictive modeling;Predisposition;Primary Brain Neoplasms;Proliferating;prototype;Radiation Dose Unit;Radiation therapy;Radiology Specialty;Randomized;Reading;reconstruction;Recurrence;Reporting;Research;Resolution;safety and feasibility;Scanning;Sensitivity and Specificity;Site;software development;software systems;Software Tools;spectroscopic data;spectroscopic imaging;standard of care;Survival Analysis;System;Systems Integration;Techniques;Technology;technology validation;Time;Tissues;tool;treatment and outcome;treatment planning;treatment response;tumor;tumor progression;two-dimensional;Update;user-friendly;Vendor;Visualization;web based software;Work

PROJECT_TITLE: Improved whole-brain spectroscopic MRI for radiation therapy planning

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: Chicago

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: NORTHWESTERN UNIVERSITY

ORG_STATE: IL

PHR: Project Narrative We propose to study the structure and mechanism of proteins, nucleic acids, and their complexes. The central theme of the work is the understanding of the atomic mechanism of crucial biological macromolecules through a combination of structural and biophysical studies. The goal of the research is to reveal paradigms for understanding fundamental biological processes.

PI_NAMEs: MONDRAGON, ALFONSO  (contact)

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TERMS: Affect;Aminoacylation;Antibiotics;Architecture;Binding;Biological;Biological Process;biophysical analysis;Cell Physiology;chemotherapeutic agent;Complex;design;DNA;Elements;Evolution;Gene Expression Regulation;Genes;Genetic Transcription;Goals;Life;Ligands;macromolecule;Malignant Neoplasms;Messenger RNA;novel therapeutics;Nucleic Acids;Property;Proteins;Research;Research Design;RNA;Role;Signal Transduction;single molecule;small molecule;Structure;Therapeutic Agents;Topoisomerase;Transfer RNA;Translations;Untranslated Regions;Untranslated RNA;Work

PROJECT_TITLE: Structural and biophysical studies of proteins, nucleic acids, and their complexes

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Pediatric;Rural Health

ORG_CITY: WARREN

ORG_NAME: NEW HAMPSHIRE ACADEMY OF SCIENCE, INC.

ORG_STATE: NH

PHR: Project Narrative The Learning Science Through Research program (LSTR) employs the scientific and educational resources of the New Hampshire Academy of Science (NHAS), the Fairbanks Museum and Planetarium (FMP), and Colby Sawyer College (CSC) in providing authentic STEM research experiences to students, their teachers, and prospective teachers from underserved rural communities. By fully involving parents, teachers, and students, the program will: 1) inform all parties to the broad and growing opportunities in health and science careers, 2) transform middle/high school science teachers into inspirational mentors and educational leaders, 3) enable students to carry out the practices of designing, executing and publishing scientific research, 4) enable teachers and students to access peer-to-peer support as well as the mentorship of experienced STEM professionals from regional STEM corporations to become ethical and productive scientists, and 5) advance the STEM career development of underserved students.

PI_NAMEs: FALETRA, PETER  (contact);MAST, JESSICA ;MICHAEL, ALYSON GWEN;WHIPPLE, CHERY ANGEL

PROGRAM_OFFICER_NAME: FAUPEL-BADGER, JESSICA

PROJECT_TERMS: Academy;American Association for the Advancement of Science;Area;Biology;Biomedical Research;career;Career Choice;career development;Career Mobility;Child;college;College Preparation;Communities;community-centered;Competence;Complex;Cookbook;Data Analyses;Depressed mood;design;Development;Education;education resources;Educational process of instructing;Engineering;Ensure;Equipment;Ethics;Event;experience;Experimental Designs;experimental study;Future;Future Teacher;Geography;Grant;Health;high school;High School Student;Human Resources;Infrastructure;inservice teacher;Institution;instrument;interest;Investigation;junior high school;Laboratories;Learning;Length;Libraries;Location;meetings;mentoring community;Mentors;Mentorship;Middle School Student;Modernization;Museums;New Hampshire;Online Systems;outreach;Parents;peer;peer coaching;peer support;planetarium;Process;Productivity;Professional Practice;programs;prospective;Publications;Publishing;Research;research to practice;Resources;Role;Rural;Rural Community;rural underserved;Schools;Science;science museum;science teacher;Scientist;Secondary Schools;Secondary to;Site;skills;STEM career;STEM research;Students;symposium;teacher;underserved students;university student;Visit;web platform;Work

PROJECT_TITLE: Learning Science Through Research

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(56)R]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: PROVIDENCE

ORG_NAME: RHODE ISLAND HOSPITAL

ORG_STATE: RI

PHR: PROJECT NARRATIVE  Pre-exposure prophylaxis (PrEP) is effective in preventing HIV infection among people who inject drugs (PWID) yet studies suggest that its use is low among this population which is particularly vulnerable to HIV infection. The criminal justice (CJ) system, at the intersection of increased risk of HIV infection and substance use, presents a unique opportunity to engage PWID in HIV prevention care that incudes PrEP. The study will characterize the facilitators and barriers to PrEP initiation, adherence and linkage to care among male PWID that are experiencing incarceration and develop the “PrEPare-for-Release” intervention to promote PrEP initiation, adherence and linkage to care upon release from incarceration into the community.

PI_NAMEs: MURPHY, MATTHEW  (contact)

PROGRAM_OFFICER_NAME: LEE-WINN, ANGELA EUNJI

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;Adult;AIDS prevention;Area;Attitude;Awareness;Behavior Therapy;Behavioral;Biometry;Caring;Centers for Disease Control and Prevention (U.S.);Clinical;Clinical Research;Clinical Trials Design;Cognitive Therapy;Communities;community reentry;Continuity of Patient Care;correctional system;Criminal Justice;Data;design;Disease Management;Disease Outbreaks;Enrollment;Ensure;Environment;Evaluation;expectation;experience;Future;Goals;Health behavior;health determinants;health inequalities;Health Personnel;Health Priorities;high risk;HIV;HIV Infections;Imprisonment;improved;Individual;infection risk;Injecting drug user;injection drug use;interest;Intervention;Interview;Knowledge;Life;Link;male;Measures;Medicine;men;men who have sex with men;Mentors;Mentorship;Methodology;Modeling;Morbidity - disease rate;mortality;motivational enhancement therapy;novel;open label;opioid use disorder;Outcome;Participant;patient oriented;Pharmaceutical Preparations;Physicians;Play;Population;Population Intervention;pre-exposure prophylaxis;prevent;Prevention approach;prevention service;preventive intervention;primary outcome;Problem Solving;Public Health;public health research;Public Health Schools;Qualitative Research;Randomized;Recommendation;Recording of previous events;Reporting;Research;Research Methodology;Research Personnel;responsible research conduct;Rhode Island;Risk;Role;Scientist;Self Efficacy;Services;skill acquisition;skills;social cognitive theory;social stigma;standard of care;Structure;substance use;Substance Use Disorder;System;therapy development;Time;Training;Training Activity;transmission process;United States;Universities;Vulnerable Populations;Work

PROJECT_TITLE: An intervention to improve HIV pre-exposure prophylaxis initiation, adherence and linkage to care for recently incarcerated men who inject drugs.

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


NIH_SPENDING_CATS: Genetics;Nutrition

ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: NARRATIVE This proposal is focused on understanding the molecular mechanisms regulating protein synthesis and stress response pathways and how these processes are beneficial or adverse in a given biomedical context. Specifically, we are addressing how a collection of protein kinases that phosphorylate a translation initiation factor, eIF2, recognize nutrient stresses and disruptions in protein folding and implement differential translational control that serves to repair and sustain cells. This research is important for understanding the progression of many diseases, including diabetes, obesity, and Non-alcoholic fatty liver disease (NAFLD), with a long term goal of development of biomarkers and therapeutic treatments.

PI_NAMEs: WEK, RONALD C (contact)

PROGRAM_OFFICER_NAME: BLATCH, SYDELLA ANNE

PROJECT_TERMS: Address;Bar Codes;Biochemistry;biological adaptation to stress;biomarker development;Cell Survival;cell type;Cells;Collection;Couples;Diabetes Mellitus;Diagnosis;Disease;Gene Expression;Gene Expression Profile;Genes;Genomics;Goals;Guanosine Triphosphate;innovation;insight;irradiation;knowledge integration;Malignant Neoplasms;Messenger RNA;Metabolic Diseases;Molecular;Molecular and Cellular Biology;mRNA Translation;neuropathology;non-alcoholic fatty liver disease;Nutrient;Obesity;Open Reading Frames;Pathway interactions;Pattern;Peptide Initiation Factors;Phosphorylation;Process;programs;Protein Biosynthesis;protein degradation;protein folding;Protein Kinase;Proteolysis;Proteome;Regulation;repaired;Repression;Research;Resources;Ribosomes;Scanning;Signal Pathway;Stress;Technology;Therapeutic;Transcription Coactivator;Translating;Translation Initiation;Translations

PROJECT_TITLE: Regulation and Function of Integrated Stress Response

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-Y(55)R]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Cancer;Contraception/Reproduction;Infertility;Organ Transplantation;Pediatric;Pediatric Cancer;Rare Diseases;Transplantation;Women's Health Research

ORG_CITY: CHICAGO

ORG_NAME: LURIE CHILDREN'S HOSPITAL OF CHICAGO

PHR: PROJECT NARRATIVE Life-saving cancer treatments can destroy the finite source of potential eggs and sex hormone-producing cells, and, therefore, ovarian tissue cryopreservation is offered to young girls as the primary fertility preservation method. Hormones and/or fertility can ultimately be restored following transplantation of cryopreserved tissue, but current methods are not suitable for those with cancer cells in the ovary, are not effective in producing children for the majority of individuals and are not long-term solutions for hormone restoration. The goal of this study is to define the microenvironment of the bank of potential eggs in order to develop an engineered ovarian transplant that restores safe, effective and long-term function for cancer survivors.

PI_NAMEs: LARONDA, MONICA M (contact)

PROGRAM_OFFICER_NAME: TAYMANS, SUSAN

PROJECT_TERMS: 3D Print;aged;Back;Biochemical;Biological;Biomedical Engineering;Bioprosthesis device;cancer cell;cancer risk;cancer survival;Cancer Survivor;cancer therapy;candidate identification;Cattle;Cell Death Induction;Cells;Charge;Chemicals;Child;Clinic;Collagen;comorbidity;Cryopreserved Tissue;Cues;Data;Development;Diagnosis;Disease;egg;EMILIN1 gene;Enabling Factors;Endothelial Cells;Engineering;Environment;experience;extracellular;Extracellular Matrix;Fertility;fertility preservation;folliculogenesis;Germ Cells;girls;Goals;Gonadal Steroid Hormones;Growing Follicle;Growth;Hormone secretion;Hormones;Housing;human model;Hydrogels;improved;In Vitro;Individual;Infertility;Life;Life Expectancy;Live Birth;Location;Longevity;Malignant Neoplasms;Measures;Methods;Modeling;Monitor;Mus;offspring;Oocytes;Outcome;Ovarian;Ovarian hormone;ovarian reserve;Ovarian Tissue;Ovarian tissue cryopreservation;Ovary;ovary transplantation;Ovulation;paracrine;Pathway interactions;Patients;pediatric patients;Physical environment;physical property;Population;pressure;primary ovarian insufficiency;Primordial Follicle;Procedures;Production;Proteins;Proteomics;Quality of life;recruit;Reporting;Resources;response;restoration;Risk;Role;Safety;scaffold;Source;Stromal Cells;success;Supporting Cell;Testing;Time;Tissues;Translations;transplant model;Transplantation;Woman;Xenograft procedure

PROJECT_TITLE: Defining the microenvironment that will enable a long-term bioprosthetic ovary transplant

STUDY_SECTION: ICER

STUDY_SECTION_NAME: Integrative and Clinical Endocrinology and Reproduction Study Section[ICER]


NIH_SPENDING_CATS: Pediatric;Prevention

ORG_CITY: WASHINGTON

ORG_NAME: CHILDREN'S RESEARCH INSTITUTE

ORG_STATE: DC

PHR: NARRATIVE The Child Health Research Center Development Award (CHRCDA) Program at CNH will train the next generation of pediatrician-scientists who will perform cutting-edge basic, translational, and clinical research on issues of importance to child health and development. While there are many opportunities to use molecular biology, biomedical engineering, and translational science to advance treatment of pediatric diseases, the required technologies and techniques are complex, labor intensive and require a comprehensive understanding of the most recent scientific advances. Because the necessary research experience is often lacking among most academic pediatricians who have recently completed clinical training, the CHRCDA Program at CNH will provide 2-4 years of career development and practical experience under the direction of committed senior mentors.

PI_NAMEs: KUPPERMANN, NATHAN  (contact)

PROGRAM_OFFICER_NAME: WINER, KAREN

PROJECT_TERMS: Address;Advisory Committees;Affinity;Applications Grants;Appointment;Area;Award;Basic Science;Biomedical Engineering;Biometry;Capital;career;Child;Child Health;Childhood;Clinical Research;Clinical Sciences;clinical training;Computing Methodologies;COVID-19 pandemic;Data;Development;Disease;Educational Curriculum;experience;Faculty;Funding;Goals;Grant;Hospitals;Immunology;improved;innovation;Investigation;Investments;K-Series Research Career Programs;Knowledge;Laboratories;Learning;Malignant Neoplasms;Measures;member;Mentors;Mentorship;Molecular Biology;Molecular Genetics;Neurosciences;Outcome;outreach;pediatrician;Pediatrics;Performance;Principal Investigator;professor;programs;Publications;recruit;Research;Research Methodology;Research Personnel;responsible research conduct;Science;Scientist;skills;Structure;Supervision;Time;Trainers Training;Training;Translational Research;United States National Institutes of Health

PROJECT_TITLE: Child Health Research Career Development Award (CHRCDA) Program at Children's National


NIH_SPENDING_CATS: Biotechnology;Genetics;Infectious Diseases;Malaria;Rare Diseases;Vector-Borne Diseases

ORG_CITY: SAINT LOUIS

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Plasmodium falciparum, a causative agent of human malaria, inflicts an enormous burden on global human health. Even though P. falciparum is a eukaryotic organism, there are vast differences in the mechanisms of mRNA translation and surveillance between P. falciparum and humans. This project will apply new approaches to understand better the evolution of the previously unexplored process of protein synthesis in the AT-rich genome of malaria parasites and exploit new parasite-specific drug targets.

PI_NAMEs: DJURANOVIC, SERGEJ  (contact)

PROGRAM_OFFICER_NAME: VATAKIS, DIMITRIOS NIKOLAOS

PROJECT_TERMS: activation-induced cytidine deaminase;Adenosine;Affect;Amino Acids;aptamer;Binding;Binding Proteins;Biological;Cell Line;Cells;Chimera organism;Codon Nucleotides;Development;Drug Targeting;Ensure;Eukaryota;Evolution;Exhibits;experimental study;fighting;Foundations;Gene Expression;Genes;Genome;genome sequencing;Genomics;Goals;Health;Human;Human Cell Line;in vivo;Knowledge;Lysine;Malaria;Mass Spectrum Analysis;Messenger RNA;Modification;mRNA Decay;mRNA Surveillance;mRNA Translation;new therapeutic target;Nonsense-Mediated Decay;novel strategies;Organism;Outcome;Parasites;Pathway interactions;Plasmodium;Plasmodium falciparum;Plasmodium falciparum genome;polyadenosine;Polylysine;Process;Protein Biosynthesis;Proteins;Proteome;Protocols documentation;Quality Control;recruit;Regulator Genes;Reporter;Ribosomal Interaction;Ribosomal Proteins;Ribosomal RNA;Ribosomes;RNA;RNA Decay;RNA purification;RNA-Binding Proteins;Running;single-molecule FRET;Starvation;stem;Stretching;Structure;System;Technology;Testing;Therapeutic;Tobramycin;transcriptome;Translating;Translations;Variant;Work

PROJECT_TITLE: Dissecting mRNA-ribosome interaction in AU-rich transcriptome of Plasmodium falciparum

STUDY_SECTION: MGA

STUDY_SECTION_NAME: Molecular Genetics A Study Section[MGA]


NIH_SPENDING_CATS: Neurosciences

ORG_CITY: CAMBRIDGE

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

ORG_STATE: MA

PHR: A Non-Human Primate Model for Closed-Loop Anesthesia Delivery Narrative Closed-loop anesthesia delivery (CLAD) systems are an invaluable, but yet unrealized paradigm that can: improve second-to-second brain state monitoring of patients during general anesthesia; provide precise computer-controlled anesthetic dosing; and reduce highly prevalent anesthetic side effects such as post-operative cognitive dysfunction. By combining pharmacokinetics and pharmacodynamic modeling with modern control theory and artificial intelligence approaches, we will develop a non-human primate model for design and testing of CLAD systems for two widely used anesthetics: propofol and dexmedetomidine. If successful, this research will provide a critical foundation for the eventual, widespread deployment of CLAD systems in anesthesiology and intensive care unit medicine.

PI_NAMEs: BROWN, EMERY N (contact)

PROGRAM_OFFICER_NAME: KUMSA, DOE WONDWOSSEN

PROJECT_TERMS: Algorithms;Anesthesia procedures;Anesthesiology;Anesthetics;Animal Model;Animals;antinociception;Artificial Intelligence;Behavior;Blood Pressure;Brain;brain dysfunction;Breathing;Caring;Central Nervous System;Circulation;Computer Assisted;Computers;control theory;COVID-19 patient;Data;Development;Dexmedetomidine;Dose;Elderly;Electroencephalography;Ensure;experience;Fostering;Foundations;General Anesthesia;Health;Heart Rate;Hour;Human;Hypotension;improved;Infusion procedures;Intensive Care Units;Left;Manuals;Medicine;model design;Modeling;Modernization;Molecular Target;Monitor;Morbidity - disease rate;Nausea;neural;neural circuit;neurophysiology;nonhuman primate;Operating Rooms;Operative Surgical Procedures;Oxygen;Pain management;Patient Care;Patient Monitoring;patient safety;Patients;Persons;Pharmaceutical Preparations;pharmacodynamic model;pharmacokinetics and pharmacodynamics;Physiologic Monitoring;Physiological;post-operative cognitive dysfunction;Propofol;Provider;Pump;Real-Time Systems;Research;Research Design;Research Project Grants;Safety;Sedation procedure;sensor;side effect;signal processing;Specific qualifier value;Syringes;System;Temperature;Testing;Time;Unconscious State;vigilance

PROJECT_TITLE: Non-Human Primate Model for Developing Closed-Loop Anesthesia Delivery Systems

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


ORG_CITY: Nashville

ORG_DEPT: BIOLOGY

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: PROJECT NARRATIVE Innate immune genes are under natural selection to protect the host from pathogens, but emerging evidence suggests that at least some immune genes may also function in development and the response to stress, complicating our understanding of immune system evolution. We plan to uncover the extent of shared genetic architecture between innate immunity and development and determine its influence on the dynamics of host-parasite coevolution. Understanding evolutionary constraints on host-microbe interactions will improve predictions for pathogen evolution and ultimately shed light on the genetic basis of sepsis and other human diseases with complex genetic origins.

PI_NAMEs: TATE, ANN THOMAS (contact)

PROGRAM_OFFICER_NAME: ADKINS, RONALD

PROJECT_TERMS: Animals;antagonist;Autoimmunity;base;biological adaptation to stress;biological systems;Complex;Data;design;Development;Disease;DNA Sequence Alteration;Evolution;expectation;experimental study;fitness;Flour;gene product;Genes;Genetic;genetic analysis;genetic architecture;genome-wide;Host Defense;host-microbe interactions;Human;human disease;human pathogen;Immune;immune function;Immune response;Immune system;Immunity;Immunological Models;Immunologics;improved;Innate Immune Response;Insecta;insight;mathematical model;Mediating;Modeling;Molecular;Natural Immunity;Natural Selections;Order Coleoptera;Outcome;Parasites;pathogen;Pathway interactions;Physiological Processes;Plants;Play;pleiotropism;Population Genetics;pressure;Process;Property;Proteins;Research;response;Role;Running;Sepsis;Shapes;Side;side effect;Source;Stress;Structure;System;system architecture;theories;Therapeutic;trait;transcriptome;Translations;Tribolium;Work

PROJECT_TITLE: The coevolutionary dynamics of pleiotropic genetic architecture

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-D(55)R]


ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

PHR: Failure of monoclonal antibody treatments against central nervous system (CNS) metastases, which occurs for 15-40% of cancer patients, is due to their inability to enter the CNS. I propose a novel nanotechnology for effective delivery of monoclonal antibodies to the CNS, potentially enabling treatments for cancers of the CNS.

PI_NAMEs: WEN, JING  (contact)

PROGRAM_OFFICER_NAME: TANDON, PUSHPA

PROJECT_TERMS: Acetylcholine;Address;analog;anti-CD20;Antibodies;Antibody Therapy;authority;B-Cell Lymphomas;Binding;Biodistribution;Biological;Biological Factors;Biomedical Engineering;Blood - brain barrier anatomy;blood-brain barrier crossing;blood-brain barrier penetration;BLR1 gene;Brain;Cancer Patient;cancer therapy;Cell surface;Cells;Central Nervous System;Central Nervous System Lymphoma;Central Nervous System Neoplasms;Cerebrospinal Fluid;Chemical Engineering;chemical property;chemical substitution;Choline;choline analog;Circulation;Clinical;Collaborations;controlled release;Crosslinker;CXCL13 gene;Data;design;Discipline;Disease;DNA;Drug Kinetics;effective therapy;Encapsulated;Environment;experience;Failure;Formulation;Gene Delivery;Genes;Immunotherapy;improved;In Situ;Individual;ineffective therapies;innovation;Intravenous;Intraventricular;Ligands;Lymphoma;macromolecule;Malignant Breast Neoplasm;Malignant neoplasm of central nervous system;Malignant Neoplasms;materials science;Mediating;Metastatic malignant neoplasm to brain;Metastatic Neoplasm to the Central Nervous System;Modeling;Molecular Target;Monoclonal Antibodies;Monoclonal Antibody Therapy;monomer;Mus;nanocapsule;nanoencapsulated;Nanotechnology;nanotechnology platform;Nature;Neoplasm Metastasis;neoplastic cell;neuropathology;neurotoxicity;new technology;Non-Hodgkin's Lymphoma;nonhuman primate;novel;novel strategies;Oncology;Pharmaceutical Preparations;polymerization;Polymers;Positioning Attribute;Property;Proteins;Publishing;Reagent;receptor;Recording of previous events;Relapse;Reporting;Research Personnel;Risk;rituximab;RNA;Rodent;Route;success;Surface;Systemic disease;targeted delivery;Technology;Therapeutic;Therapeutic Effect;therapeutic evaluation;Therapeutic Monoclonal Antibodies;therapeutic protein;Thinness;Time;Trastuzumab;Treatment Efficacy;tumor;Tumor Burden;tumor growth;virtual;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Targeting delivery of mAbs to CNS metastases

STUDY_SECTION: DMP

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology Study Section[DMP]


NIH_SPENDING_CATS: Genetics;Human Genome;Women's Health Research

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF HOUSTON

ORG_STATE: TX

PHR: PROJECT NARRATIVE Transposable elements are mobile DNA sequences which spread through eukaryotic genomes, making up ~50% of the human genome. The mobilization of transposable elements is implicated in the onset and progression of many cancers, as well as age-related neurodegenerative diseases. The proposed research uses Drosophila melanogaster as a model to reveal the mechanisms and evolution of host cellular responses to transposon mobilization.

PI_NAMEs: KELLEHER, ERIN S (contact)

PROGRAM_OFFICER_NAME: MACARTHUR, LINDA

PROJECT_TERMS: age related neurodegeneration;Alleles;Cells;Cellular Stress;Collection;Complex;cost;Development;DNA;DNA Damage;DNA Sequence;DNA Transposable Elements;DNA Transposons;Dose;Drosophila melanogaster;Elements;Evolution;Excision;experimental study;Female;fitness;Future;Gametogenesis;genetic analysis;genetic variant;Genome;Genomics;Genotoxic Stress;genotoxicity;Germ Lines;Goals;Heterochromatin;Human Genome;innovation;Invaded;Malignant Neoplasms;Maps;Modeling;mutant;Mutation;Nuclear;Oogenesis;Parasites;Population;Quantitative Trait Loci;Recording of previous events;Repression;Research;Resistance;resistance mechanism;response;Shapes;Shock;Small RNA;Taxonomy;transposon/insertion element;Tremor;tumor;Variant

PROJECT_TITLE: Mechanisms and Evolution of Host Tolerance to Transposable Elements

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-K(55)R]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_NAME: VA  MEDICAL CENTER

PHR: Nearly half of all patients with epilepsy have deficits in attention and executive function, with no available medical treatment. To determine efficacy of methylphenidate (MPH) for the treatment of epilepsy-related cognitive dysfunction would be of particular importance to combat Veterans and others with traumatic brain injuries (TBI), as epilepsy and neuropsychological dysfunction are among the most common sequelae of TBI. If MPH is shown to be efficacious and safe for the treatment of epilepsy-related cognitive dysfunction in a large randomized, double-blind, placebo controlled trial over an extended treatment period in patients with post- traumatic and other epilepsies, the results could guide clinical management and greatly impact daily function, quality of life, and employability in Veterans with seizures.

PI_NAMEs: LEEMAN-MARKOWSKI, BETH AMI (contact)

PROJECT_TERMS: Activities of Daily Living;Adult;Adverse event;Anticonvulsants;Anxiety;Arousal;Attention;Attention deficit hyperactivity disorder;Attentional deficit;Beck depression inventory;Blinded;Boston;Brain;Child;Clinical;Clinical Management;clinically relevant;Cognition;Cognitive;cognitive ability;cognitive benefits;Cognitive deficits;cognitive function;cognitive performance;cognitive process;cognitive testing;Color;combat veteran;comorbidity;computerized;Craniocerebral Trauma;daily functioning;Databases;Digit structure;Dose;Double-Blind Method;double-blind placebo controlled trial;efficacy evaluation;Epilepsy;Equipment and supply inventories;Etiology;executive function;expectation;FDA approved;Frequencies;Functional disorder;Healthcare Systems;Hospitals;Impact Seizures;Impaired cognition;Impairment;improved;Impulsivity;Lesion;Measures;Medical;medical schools;Memory;Methods;Modality;Moods;Neuropsychology;open label;Outcome Measure;Patient Self-Report;Patients;Performance;performance tests;Pharmaceutical Preparations;Phase;Placebo Control;Placebos;Post-Traumatic Epilepsy;primary endpoint;primary outcome;psychiatric comorbidity;Quality of life;Quality of Life Assessment;Randomized;Recording of previous events;recruit;Registries;rehabilitation strategy;Research;response;Risk;Ritalin;Safety;secondary analysis;Seizures;side effect;Site;Speed;Stimulant;sustained attention;Syndrome;System;Testing;Titrations;Traumatic Brain Injury;treatment duration;Veterans

PROJECT_TITLE: Methylphenidate for the treatment of epilepsy-related cognitive deficits: a randomized, double-blind, placebo-controlled trial


NIH_SPENDING_CATS: Bioengineering;Genetics

ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: Project Narrative Over a decade after the release of the human genome sequence, we are continuing to discover that many diseases arise from mutations in DNA regulatory regions, which “decide” specifically where and when to produce proteins in our bodies. While we have made great progress in our ability to predict where proteins will be produced, we have only recently begun to appreciate how much DNA sequence precisely dictates when production will ensue. The work proposed here seeks to reach a predictive understanding of these processes that will empower scientists and physicians to “read out” when and where cellular decisions are made from DNA sequence, just as the function of an electronic circuit can be predicted from its wiring diagram. This understanding, combined with synthetic biology, will set the stage for the predictive bioengineering of the development of multicellular organisms and future precision therapeutic tools for repairing developmental defects and halting states of unchecked cellular proliferation in cancer.

PI_NAMEs: GARCIA, HERNAN GUSTAVO (contact)

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TERMS: Acetylation;Affect;Binding;Binding Sites;Biochemical;Biological Assay;Biomedical Engineering;Case Study;Cell Cycle;Cell Proliferation;Cells;Chromatin;chromatin modification;Cytoplasm;Data;Decision Making;Defect;Development;Developmental Biology;Disease;Dissection;DNA;DNA Sequence;Drosophila genus;Drosophila melanogaster;Electronics;Embryo;Embryonic Development;empowerment;Engineering;experimental study;fly;Future;Gene Expression;Genes;Genetic Transcription;genome-wide;genome-wide analysis;Germ Lines;Histone Acetylation;histone acetyltransferase;Histone Deacetylase;Histones;Human Genome;in vivo;Investigation;knock-down;Knock-out;Libraries;Malignant Neoplasms;Measurement;Measures;Messenger RNA;Microscope;Modeling;Molecular;mutant;Mutation;Nature;new technology;Nucleic Acid Regulatory Sequences;optogenetics;Organism;Output;Pathway interactions;Pattern;Physicians;Play;Precision therapeutics;predictive modeling;Process;Production;programs;promoter;Proteins;Regulation;repaired;Reporter;Role;Scientist;Series;Shapes;single molecule;small hairpin RNA;spatiotemporal;Structure;synthetic biology;Technology;temporal measurement;Testing;Theoretical model;theories;Time;tissue fixing;tool;transcription factor;Transcription Initiation;Transcriptional Regulation;Work

PROJECT_TITLE: Predictive understanding of the temporal control of transcription in Drosophila development

STUDY_SECTION: MABS

STUDY_SECTION_NAME: Modeling and Analysis of Biological Systems Study Section[MABS]


NIH_SPENDING_CATS: Genetics;Neurosciences

ORG_CITY: MEMPHIS

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

PHR: Project Narrative: Neural circuits in the spinal cord are directly responsible for controlling movement, and damage to these circuits through neurodegenerative disorders or acute trauma can severely impair motor output. The research described in this proposal aims to significantly advance the understanding of the identity and circuitry of interneurons in the spinal motor system, which should facilitate the development of new therapeutic approaches to the treatment of developmental motor disabilities and spinal cord injury.

PI_NAMEs: BIKOFF, JAY BENJAMIN (contact)

PROJECT_TERMS: Acute;Address;Adolescent;Adult;Behavior;Brain;brain pathway;cell type;Data;Development;Electrophysiology (science);Elements;Embryo;Exhibits;experimental study;Forelimb;Foundations;FOXP2 gene;Future;Gene Expression;Genetic;Goals;Interneuron function;Interneurons;Knowledge;limb movement;Limb structure;Link;Locomotion;Logic;Mediating;Methods;Molecular;Motor;motor behavior;motor control;Motor disability;motor disorder;motor impairment;Motor Neurons;Motor output;Motor Pathways;Movement;Mus;Muscle Contraction;mutant;Mutant Strains Mice;Nature;Neonatal;neonatal mice;Nervous System control;neural circuit;Neurodegenerative Disorders;Neurons;neuroregulation;novel therapeutic intervention;Output;Pathway interactions;Periodicity;Physiological;Play;Population;Positioning Attribute;programs;Rabies;reconstruction;Research;Role;segregation;selective expression;Series;Shapes;skills;Spatial Distribution;Speed;Spinal;Spinal Cord;Spinal cord injury;Stereotyping;Synapses;System;Testing;transcription factor;Transgenic Organisms;Trauma;Viral

PROJECT_TITLE: Interneuron circuits in the spinal motor system

STUDY_SECTION: SMN

STUDY_SECTION_NAME: Sensory-Motor Neuroscience Study Section[SMN]


ADMINISTERING_IC: NR

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Pain Research;Palliative Care;Pediatric;Social Determinants of Health

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE About 90,000 US children, adolescents, and young adults live with a severe neurologic impairment; these children are typically marginalized and understudied, and a majority suffer from uncontrolled pain. Using a rigorous research approach, we propose to pilot test the PediQUEST ResPOND intervention, which combines the use of electronic parent reported outcome measures with integration of a specialized pediatric palliative care team to systematically address pain and distress in these underserved children and their parents that, if successful, will lead to a multisite Phase III trial. The proposal ultimately aims to improve quality of life and promote health equity and access in children with severe neurologic impairment and their parents, which is aligned with top priorities of the National Institute of Nursing Research, National Academy of Medicine, and World Health Organization.

PI_NAMEs: WOLFE, JOANNE  (contact)

PROGRAM_OFFICER_NAME: KEHL, KAREN

PROJECT_TERMS: 1 year old;Academy;acceptability and feasibility;Activities of Daily Living;Acute Pain;Address;Adolescent and Young Adult;Advanced Malignant Neoplasm;Advocate;American;Anxiety;Back;Case Series;Central Nervous System Diseases;Child;Child Care;Child Welfare;Childhood;chronic pain;Collection;Complementary therapies;Consultations;coping;Data;design;Development;disability;disadvantaged background;Distress;efficacy trial;Electronics;Eligibility Determination;Enrollment;Evaluation;Exclusion;experience;Family;family burden;Family health status;Feasibility Studies;Feedback;Feeds;Funding;Goals;Health;health equity promotion;Impaired cognition;Impairment;improved;Inequity;Intervention;intervention refinement;Intervention Studies;Interview;Low income;Malignant Childhood Neoplasm;Manuals;marginalization;marginalized population;Mediating;medical specialties;Medicine;Mental Depression;Minority;Modeling;Monitor;motor impairment;National Institute of Nursing Research;Neurologic;Neurological disability;novel;Outcome;Outcome Measure;Pain;pain behavior;Palliative Care;Parents;Participant;Patients;Pediatrics;Personal Satisfaction;Phase;phase III trial;Pilot Projects;pilot test;Population;Positioning Attribute;Primary Care;Principal Investigator;Procedures;psychological distress;Quality of life;Randomized;Randomized, Controlled Trials;Recommendation;recruit;Recurrence;Recurrent pain;Reporting;Research;Research Design;response;Running;Sample Size;screening;Site;sleep quality;social stigma;Standardization;Stigmatization;Stress;Structure;Surveys;Symptom Burden;symptom management;Symptoms;Technology;Testing;therapy development;Training;treatment as usual;World Health Organization;Writing

PROJECT_TITLE: PediQUEST ResPOND: Piloting an intervention to treat recurrent pain in children with severe neurological impairment

STUDY_SECTION: ICSC

STUDY_SECTION_NAME: Interdisciplinary Clinical Care in Specialty Care Settings Study Section[ICSC]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE Microtubule motor-based transport is essential for the clearance of phagosomes in the retinal pigment epithelium (RPE), a cell type that performs numerous functions essential for the health of the retina, and therefore normal vision. The proposed project will utilize advanced techniques in molecular and cell biology, in combination with state-of-the-art live-cell imaging, to investigate the role of dynein in phagosome transport, maturation, and clearance, in human RPE. This study will advance our current understanding of phagosomal transport, and the mechanisms by which microtubule motors operate to ensure the fidelity of this vital RPE function.

PI_NAMEs: HAZIM, RONI  (contact)

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: Adaptor Signaling Protein;Affect;Applications Grants;Area;Award;Back;cell type;Cells;Cellular biology;combinatorial;Complex;Cytoplasm;Data;Defect;Development Plans;Dynein ATPase;Endosomes;Ensure;Epithelium;Eukaryotic Cell;Exhibits;Funding Mechanisms;Goals;Health;Human;Hybrids;Impairment;Institution;Intracellular Transport;Investigation;Kinesin;Kinetics;Knowledge;Laboratories;late endosome;Link;live cell imaging;Lysosomes;Macular degeneration;Measures;Mediating;Melanosomes;Mentors;Microtubules;migration;Minus End of the Microtubule;Mitochondria;Molecular;Molecular Biology;Molecular Motors;Motility;Motor;motor control;Movement;novel;Organelles;Pathology;peroxisome;Phagocytosis;Phagosomes;Physiological;Play;Plus End of the Microtubule;polarized cell;Positioning Attribute;Preparation;prevent;Principal Investigator;Process;programs;protein transport;Proteins;Regulation;Research;Research Training;Retina;Role;Route;Specificity;Structure;Structure of retinal pigment epithelium;Surface;symposium;Techniques;Testing;tool;trafficking;Training;Vision;vision science

PROJECT_TITLE: In-depth molecular studies of dynein transport in the RPE


NIH_SPENDING_CATS: Natural Products

ORG_DEPT: CHEMISTRY

PHR: Project Narrative The detailed examination of the fundamental chemistry and biological mechanism of action of natural products is critical in the development of new treatments for a variety of human ailments. This program aims to discover, develop, and apply new chemical synthesis strategies and methodologies for efficient preparation of bioactive and structurally complex natural products and designed derivatives. Whereas the immediate impact of this program is access to precious and rare samples of complex alkaloids for structure validation, collaborative biological evaluation, and mechanistic studies, the long-term and broader impact of this program is the establishment of precedence for the application of new chemistries in synthesis of other complex molecules, natural or rationally designed, with therapeutic potential.

PI_NAMEs: MOVASSAGHI, MOHAMMAD  (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TITLE: Development of New Strategies for Chemical Synthesis and Study of Complex Natural Products

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-P(55)R]


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Emergency Care;Epilepsy;Neurodegenerative;Neurosciences;Pediatric;Prevention

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

PHR: Narrative Childhood status epilepticus (SE) is a common life-threatening emergency, with a high risk of death and high risk of disability among survivors. This large cohort study of children with SE in northern Nigeria will determine the phenotypes of childhood SE, clinical and genomic predictors of SE resistance to specific first-line drugs (benzodiazepines), clinical and genomic predictors of SE outcome (death and disability), and clinical and genomic predictors of epilepsy among children who survive SE as their first seizure. This research may lead to a better understanding of this cause of childhood death and disability, informing future improved strategies for treatment and prevention.

PI_NAMEs: RAMSAY, MICHELE MICHELE;SABO, UMAR ABBA;TREVATHAN, EDWIN  (contact)

PROGRAM_OFFICER_NAME: HARTMAN, ADAM L

PROJECT_TERMS: Academic Medical Centers;Accident and Emergency department;Address;Africa;Africa South of the Sahara;African;Age;Asia;Awareness;Benzodiazepines;Biological Sciences;Blood;Brain imaging;brain magnetic resonance imaging;Candidate Disease Gene;Caring;Central Nervous System Infections;Cessation of life;Child;Childhood;Cities;Clinical;clinical predictors;clinical risk;cohort;Cohort Studies;Collaborations;Collection;Community Health;Country;Data;Data Collection;Data Coordinating Center;Development;disability;disability risk;DNA;EEG-based imaging;Electroencephalography;Electronics;Emergency Situation;Enrollment;Epilepsy;Europe;experience;Family;Frequencies;Funding;Future;Gender;Genetic;genome wide association study;genomic data;genomic predictors;Genomics;global health;Grant;high risk;Hospitals;Human;human disease;Hypoglycemia;improved;Incidence;Income;Infant;innovation;insight;Laboratories;Life;low and middle-income countries;Medical History;Medical Records;modifiable risk;Molecular;Morbidity - disease rate;mortality;mortality risk;Neurological disability;Neurological emergencies;Neurology;Nigeria;North America;Outcome;pediatric emergency;Pharmaceutical Preparations;Phenotype;phenotypic data;Physicians;point of care;Population Control;Prevention;Probability;Publishing;Randomized, Controlled Trials;Recording of previous events;Recurrence;Research;Resistance;Rest;Risk;Risk Factors;screening;Seizures;Site;South Africa;Specialist;Standardization;Status Epilepticus;Survivors;System;Teaching Hospitals;Technology;Testing;Training;Treatment Protocols;treatment strategy;United States National Institutes of Health;Universities;Variant;Video Recording;Wit

PROJECT_TITLE: Childhood Status Epilepticus and Epilepsy Determinants of Outcome (SEED)


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Dementia;Fragile X Syndrome;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: NEW YORK

ORG_DEPT: NEUROSCIENCES

ORG_NAME: NEW YORK UNIVERSITY

PHR: Project Narrative Previous studies have identified the signaling pathways that couple receptors to the translation machinery to regulate protein synthesis during long-lasting synaptic plasticity and long-term memory formation, and several of these translational control pathways are dysregulated in brain disorders including Alzheimer’s disease (AD), fragile X syndrome (FXS), and autism spectrum disorder (ASD). In this proposal we will use novel mouse lines and viruses that we have developed to determine the specific cell types in the amygdala, hippocampus, and prefrontal cortex that require de novo protein synthesis for memory consolidation, reconsolidation, and extinction, and will identify the mRNAs that are translationally regulated following learning in these cells. In addition, we will utilize ribosomal profiling, translating ribosome affinity profiling, and de novo proteomics in mouse models of FXS and AD in order to generate new therapeutic targets for these devastating disorders.

PI_NAMEs: KLANN, ERIC  (contact)

PROGRAM_OFFICER_NAME: LEE, CRYSTAL ANNE

PROJECT_TERMS: Address;Affinity;Alzheimer's Disease;Alzheimer's disease model;Amygdaloid structure;Auditory;autism spectrum disorder;Behavior;Behavioral Paradigm;Biochemical;Brain Diseases;cell type;Cells;Complex;Discrimination;Disease;EIF-2alpha;Electrophysiology (science);Event;excitatory neuron;Extinction;Fragile X Syndrome;Functional disorder;Genetically Engineered Mouse;Hippocampus;immunocytochemistry;in vivo;inhibitory neuron;innovation;insight;Laboratories;Learning;long term memory;Measures;Memory;memory consolidation;Memory Disorders;memory process;Messenger RNA;Methods;Molecular;mouse model;mRNA Translation;multidisciplinary;Mus;Neurodegenerative Disorders;Neurodevelopmental Disorder;new therapeutic target;novel;Pathway interactions;Peptide Initiation Factors;Prefrontal Cortex;Protein Biosynthesis;Proteins;Proteomics;receptor;ribosome profiling;Ribosomes;Rodent;Role;Signal Pathway;Synapses;Synaptic plasticity;therapeutic target;Translating;Translational Regulation;Translations;Virus

PROJECT_TITLE: Translational Control in Memory and Brain Disorders


NIH_SPENDING_CATS: Autoimmune Disease;Genetics;Prevention

ORG_CITY: STANFORD

ORG_DEPT: GENETICS

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE Innate immunity must be tightly controlled to fight pathogen infection as well as to prevent autoimmune disease. An RNA editing enzyme termed ADAR1 is a key regulator of innate immunity preventing the unwanted autoim- munity. To understand the molecular basis for autoimmunity and to ultimately harness this understanding for therapeutic development, we will investigate the underlying regulatory mechanisms of how ADAR1 functions along with other players at the molecular and cellular level.

PI_NAMEs: LI, JIN BILLY  (contact)

PROJECT_TERMS: ADAR1;Address;Adenosine;Autoimmune Diseases;Autoimmunity;Biochemical;Biological Assay;Cell Nucleus;Cells;Cytoplasm;Defect;Disease;Double-Stranded RNA;Enzymes;fighting;Genetic Screening;In Vitro;in vivo;Infection;Innate Immune Response;innovation;Inosine;Knowledge;Mediating;Molecular;mouse model;Natural Immunity;Nuclear;pathogen;Pathogenicity;Pathway interactions;prevent;Protein Isoforms;Regulation;RNA Binding;RNA Editing;sensor;Testing;therapeutic development

PROJECT_TITLE: Regulatory and Mechanistic Understanding of ADAR-Mediated RNA Editing

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


NIH_SPENDING_CATS: Genetics

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE When a cell reproduces, the chromosomes are first duplicated and then segregated into a pair of daughter cells. The proposed studies focus on regulatory proteins that control chromosome segregation. This research will provide a better understanding of how errors in this process can result in genetic damage or defects in chromosome number, which can accelerate cancer progression or cause developmental defects.

PI_NAMEs: MORGAN, DAVID OWEN (contact)

PROGRAM_OFFICER_NAME: XU, JIANHUA

PROJECT_TERMS: Acceleration;Affinity;anaphase-promoting complex;Binding;Biochemical;Cancer Etiology;Cell Cycle;Cell Cycle Progression;Cell Cycle Regulation;Cell division;Cells;Cellular biology;chaperonin;Chromosome Segregation;Chromosomes;cohesin;Complex;Cyclin-Dependent Kinases;Cyclins;Cytokinesis;daughter cell;Defect;Development;Disease;Enzymes;Eukaryotic Cell;Event;event cycle;fascinate;Gene Expression;Genetic;genetic regulatory protein;Genetic Transcription;histone H1 kinase;Human;human disease;information processing;insight;Investigation;Malignant Neoplasms;Measurement;Mediating;Mitosis;Mitotic spindle;Phosphorylation Site;Process;Protease Inhibitor;Proteins;PTTG1 gene;Research;S phase;Saccharomycetales;segregation;separase;single molecule;Substrate Interaction;System;tumor progression;ubiquitin ligase;Variant;Work

PROJECT_TITLE: Regulatory Enzymes and Systems in Cell Cycle Control


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;HIV/AIDS;Health Services;Infectious Diseases;Mental Health;Prevention;Women's Health Research

ORG_CITY: RESEARCH TRIANGLE PARK

ORG_NAME: RESEARCH TRIANGLE INSTITUTE

ORG_STATE: NC

PHR: PROJECT NARRATIVE Despite considerable progress toward global goals for ending the HIV epidemic, limited utilization of HIV services by those at highest risk continues to drive HIV transmission. In western Kenya, men who purchase sex constitute a particularly high-priority population because they face high risk of HIV infection and are inherently challenging to identify and reach with existing approaches. This project will evaluate an HIV self- testing intervention that relies on sexual networks to reach men who purchase sex and promote their utilization of essential HIV services.

PI_NAMEs: NAPIERALA, SUE  (contact)

PROGRAM_OFFICER_NAME: GREENWOOD, GREGORY LOUIS

PROJECT_TERMS: Address;Africa South of the Sahara;AIDS prevention;Caring;Clinic;Cluster randomized trial;Computerized Medical Record;contextual factors;cost;cost effective;cost effectiveness;Cost Effectiveness Analysis;Counseling;Couples;Data;Diagnosis;Diagnostic Reagent Kits;effectiveness evaluation;Effectiveness of Interventions;Enrollment;Epidemic;experience;Face;Female;follow-up;Geography;Goals;Health;high risk;high risk men;high risk population;High Risk Woman;HIV;HIV Infections;Hot Spot;Hour;Human immunodeficiency virus test;incremental cost-effectiveness;indexing;Individual;innovation;Intervention;Interview;Kenya;Liquid substance;Location;male;Measures;men;Modeling;Oral;Pathway interactions;patient population;Pattern;Persons;Pilot Projects;pilot test;Population;Population Sizes;Positioning Attribute;pre-exposure prophylaxis;Prevalence;Prevention;primary outcome;process evaluation;programs;Qualitative Research;Questionnaires;Randomized;randomized trial;recruit;Reporting;Research;Research Personnel;secondary outcome;self testing;service delivery;Services;sex;Sexual Partners;standard of care;Testing;testing services;tool;transactional sex;transmission process;trial design;uptake;Woman;women's treatment

PROJECT_TITLE: Reaching the last 20%: a targeted HIV self-test secondary distribution intervention to engage high-risk men in Kenya

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Dissemination and Implementation Research;HIV/AIDS;Health Services;Infectious Diseases;Prevention;Social Determinants of Health;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

PHR: PROJECT NARRATIVE. Male smoking prevalence in Viet Nam is one of the highest in the world (45%), and rates of tobacco use are even higher among people living with HIV/AIDS (PLWHA) (59%). The goal of this proposal is to conduct a randomized controlled trial that compares the effectiveness and cost-effectiveness of three multi-component interventions that are embedded in HIV outpatient clinics. The research is significant for its potential to guide large-scale adoption of promising, cost effective strategies for implementing and disseminating tobacco use treatment in HIV care settings in Viet Nam and will serve as a model for similar action in other LMICs.

PI_NAMEs: NGUYEN, NAM TRUONG;SHELLEY, DONNA R (contact)

PROGRAM_OFFICER_NAME: PARASCANDOLA, MARK

PROJECT_TERMS: Abstinence;Acquired Immunodeficiency Syndrome;Adoption;Ambulatory Care Facilities;arm;Belief;Biochemical;Caring;Cessation of life;Cities;Climate;Clinic;Clinical;Collaborations;comorbidity;comparative cost effectiveness;compare effectiveness;contextual factors;cost;cost effective;cost effectiveness;Counseling;Data;Effectiveness of Interventions;effectiveness testing;evidence base;Focus Groups;forging;Funding;General Population;Goals;Health;health care delivery;health care settings;Health Personnel;HIV;HIV/AIDS;hybrid type 1 trial;Hybrids;implementation evaluation;implementation framework;implementation process;implementation strategy;implementation study;implementation trial;Infrastructure;Intervention;Interview;low and middle-income countries;male;Medical;men;Modeling;Morbidity - disease rate;multi-component intervention;Neighborhood Health Center;nicotine patch;nicotine replacement;non-smoker;Outcome Measure;Outpatients;Patients;Persons;Policy Maker;post intervention;premature;Prevalence;Primary Care;primary outcome;Process Assessment;Provider;provider adherence;Public Health;public policy on tobacco;quitline;Randomized;Randomized, Controlled Trials;recruit;Research;Research Personnel;Resources;Risk;Science;secondary outcome;Site;Smoke;Smoking;smoking abstinence;smoking prevalence;social;social culture;Source;standard care;Structure;Surveys;System;three-arm study;Tobacco;tobacco abstinence;tobacco cessation intervention;Tobacco use;Tobacco Use Cessation;tobacco user;Training;treatment guidelines;treatment services;trial design;United States National Institutes of Health;Universities;Vietnam;Vietnamese;Village Health Workers;Woman;Work

PROJECT_TITLE: Implementing  tobacco use treatment in HIV clinics in Viet Nam

STUDY_SECTION: DIRH

STUDY_SECTION_NAME: Dissemination and Implementation Research in Health Study Section[DIRH]


ADMINISTERING_IC: HL

ED_INST_TYPE: OVERALL MEDICAL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Infectious Diseases;Precision Medicine

ORG_CITY: TYLER

ORG_NAME: UNIVERSITY OF TEXAS HLTH CTR AT TYLER

PHR: For four decades, advanced-stage empyema in adults, a disease with high rates of mortality in the elderly, has lacked diagnostic tests to advise clinical decision-making and approved non-surgical interventions. By combining novel companion diagnostic test, FPA, that predicts treatment outcomes with the delivery of low dose PAI-1- targeted fibrinolytic therapy, we will define a personalized, safe and efficient treatment for advanced-stage empyema.

PI_NAMEs: FLOROVA, GALINA ;IDELL, STEVEN ;KOMISSAROV, ANDREY  (contact)

PROGRAM_OFFICER_NAME: VUGA, LOUIS J

PROJECT_TERMS: Acute;Address;Adult;animal old age;Antibiotics;Bacterial Infections;Binding;Biochemical;Biological Assay;Biotechnology;candidate identification;chest computed tomography;Child;clinical decision-making;Clinical Research;Clinical Trials;comorbidity;companion diagnostics;Complication;Death Rate;Development;diagnostic assay;diagnostic strategy;Diagnostic tests;Disease;Docking;Dose;Drainage procedure;effective therapy;efficacy testing;effusion;Elderly;Empyema;Failure;FDA approved;Fibrin;Fibrinolysis;Gender;Hemorrhage;Human;improved;improved outcome;Incidence;Injections;Injury;innovation;Intervention;juvenile animal;Legal patent;Liquid substance;Lung;Medicine;Meta-Analysis;Modeling;Molecular;Molecular Target;Monitor;Monoclonal Antibodies;mortality;novel;novel diagnostics;Operative Surgical Procedures;Oryctolagus cuniculus;outcome prediction;Pathogenesis;Patients;Peptides;personalized approach;personalized medicine;Phage Display;Phase;Phase II Clinical Trials;Plasma;Plasminogen Activator;Plasminogen Activator Inhibitor 1;Pleural;Pleural effusion disorder;Pneumonia;Positioning Attribute;Prediction of Response to Therapy;Prior Therapy;Probability;prospective;Reagent;Research;research clinical testing;Resistance;Resolution;response;Risk;risk mitigation;Sampling;Schedule;Site;Solid;Streptococcus pneumoniae;success;Technical Expertise;Techniques;Technology;Testing;therapy outcome;Thoracentesis;Thoracotomy;Thrombolytic Therapy;Time;Translational Research;translational therapeutics;treatment optimization;Treatment outcome;treatment strategy;Ultrasonography;Uncertainty;Video-Assisted Thoracic Surgery;Work

PROJECT_TITLE: Delivery of PAI-1-targeted intrapleural fibrinolytic therapy for empyema

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Depression;Mental Health;Neurosciences

ORG_CITY: ITHACA

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: CORNELL UNIVERSITY

PHR: PROJECT NARRATIVE Calcium influx in dendritic spines is essential for synaptic plasticity. In this project, we will investigate how ketamine influences calcium signaling in dendritic spines in the mouse frontal cortex, and whether this process contributes to the compound’s rapid antidepressant effects. The results may provide important insights into the biological basis of the action of fast-acting antidepressants.

PI_NAMEs: KWAN, CHUN-HAY ALEX  (contact)

PROGRAM_OFFICER_NAME: NADLER, LAURIE SUE

PROJECT_TERMS: Acceleration;Acute;Affect;Amygdaloid structure;Animals;anti-depressive agents;antidepressant effect;Apical;Architecture;Behavioral;behavioral outcome;Biological;Biology;Brain;Brain region;Calcium;Calcium Signaling;Chronic stress;Color;Data;Dendrites;Dendritic Spines;density;Development;Diameter;Dorsal;Electric Stimulation;Evaluation;Exhibits;experimental study;Frequencies;frontal lobe;Goals;Head;Heterogeneity;Hour;Image;imaging approach;in vivo;in vivo optical imaging;insight;Ketamine;Maps;Measures;Mechanics;Medial;Mental Depression;Molecular;Morphology;Mus;nerve supply;novel;postsynaptic;predictive marker;Process;Research;Resolution;Role;Saline;social defeat;Source;Specificity;Stress;Structure;Synapses;Synaptic plasticity;Testing;Thalamic structure;two photon microscopy;Vertebral column;Visualization;Work

PROJECT_TITLE: A Dendritic Substrate for Fast-Acting Antidepressant Action

STUDY_SECTION: MNPS

STUDY_SECTION_NAME: Molecular Neuropharmacology and Signaling Study Section[MNPS]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Autoimmune Disease;Bioengineering;Biotechnology;Brain Disorders;Genetics;Multiple Sclerosis;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_NAME: ADVANCED SCIENCE RESEARCH CENTER

PHR: Myelinating glial cells traditionally viewed as inert “insulation” to neuronal processes, simply providing functional support, have been recently reported to respond to a variety of stimuli (i.e. social environment, gut metabolites, mechanical forces). The detection of their impaired function in a number of neurological and psychiatric conditions, even in the absence of neuronal damage, has led to new interest in understanding the biology of oligodendrocyte lineage cells and in developing myelin regenerative strategies. This proposal addresses key open questions with the potential to open new venues of regulation of the regenerative process in response to external signals.

PI_NAMEs: CASACCIA, PATRIZIA  (contact)

PROGRAM_OFFICER_NAME: TYLER, WILLIAM A

PROJECT_TERMS: Address;Adult;Aging;Animal Model;Automobile Driving;Autopsy;Biological;Biology;Biophysics;Biosensor;Brain;brain health;Cell Lineage;Cellular biology;Chemical Engineering;Chemicals;Collaborations;depression model;design;Detection;Development;Discipline;DNA;Enzymes;Epigenetic Process;epigenetic regulation;epigenomics;experience;Foundations;Functional disorder;Gene Expression;gene repression;Goals;Histones;Human;Impairment;interdisciplinary approach;interest;Knowledge;mechanical force;mechanical stimulus;Mental disorders;Metabolic;Modality;Multiple Sclerosis;Myelin;myelination;Nanotechnology;Nervous System Disorder;Neuroglia;Neurologic;Neurons;neuropathology;novel;novel therapeutic intervention;oligodendrocyte lineage;oligodendrocyte progenitor;Oligodendroglia;Physical environment;Process;progenitor;Proliferating;Proteomics;regenerative;regenerative approach;Regulation;remyelination;Reporting;response;Signal Transduction;social;Social Environment;spectroscopic imaging;stem cell differentiation;stem cells;Stimulus;superresolution microscopy;tool;Transgenic Mice;Transgenic Organisms;Undifferentiated

PROJECT_TITLE: Environmental Biosensors in the Oligodendrocyte Lineage


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Bioengineering;Breast Cancer;Cancer;Genetics;Women's Health Research

ORG_DEPT: PHARMACOLOGY

PHR: NARRATIVE Many patients with in situ breast cancers are overtreated because we cannot predict which of these cancers will progress to form dangerous invasive tumors. We will identify the molecular and physical changes to breast cancer cells that are necessary to progress to invasive disease using primary human breast tissue and genetically engineered mouse models. Successful completion of our long-term goals will decrease the fraction of women given radical treatments for low risk in situ tumors, and provide new targets for preventing the progression of these tumors to invasive disease.

PI_NAMEs: GARTNER, ZEV JORDAN (contact);GOGA, ANDREI ;LABARGE, MARK A;THOMSON, MATTHEW W.

PROGRAM_OFFICER_NAME: MILLER, DAVID J

PROJECT_TERMS: Acceleration;Adhesions;AKT inhibition;Architecture;Basement membrane;Binding Sites;Bioinformatics;Biological Assay;Breast;Breast Cancer Cell;Breast Cancer Prevention;breast cancer progression;Breast Epithelial Cells;Cell Adhesion Molecules;Cell Lineage;cell motility;Cell Separation;cell type;Cells;cellular engineering;Chemicals;Clinical;Complex;Dangerousness;Defect;derepression;Disease;Disease Marker;Disease Progression;drug development;Drug Targeting;Duct (organ) structure;Entropy;Epithelial Cell Proliferation;Epithelial Cells;Epithelium;Exclusion;Experimental Models;Extracellular Matrix;Extracellular Matrix Proteins;Genes;Genetic;Genetic Transcription;Genetically Engineered Mouse;Goals;Human;Image;In Situ;In Vitro;in vivo;infiltrating duct carcinoma;inhibitor;innovation;interfacial;Invaded;lens;Lobule;Malignant Breast Neoplasm;Malignant Neoplasms;Mammaplasty;mammary epithelium;Mammary gland;Mammary Gland Parenchyma;Mass Spectrum Analysis;mathematical model;Measurement;Measures;mechanical drive;mechanical energy;Mechanics;Mediating;Molecular;mouse model;Mutation;Myoepithelial;neoplastic cell;Noninfiltrating Intraductal Carcinoma;Operative Surgical Procedures;Organoids;Pathway interactions;Patients;Penetration;Peptide Hydrolases;Phenotype;PIK3CA gene;Polycomb;Positioning Attribute;predictive modeling;prevent;Probability;programs;Property;Publishing;reconstitution;Risk;self organization;Signal Transduction;single-cell RNA sequencing;small hairpin RNA;Statistical Mechanics;Structure;System;Temperature;Testing;Therapeutic;three dimensional cell culture;Tissue Engineering;Tissue Model;Tissues;tumor;Tumor Cell Invasion;tumor progression;Western Blotting;Woman

PROJECT_TITLE: Understanding breast cancer progression as a defect in the mechanics of tissue self-organization


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Electronic Nicotine Delivery Systems;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Prevention;Social Determinants of Health;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE The proposed research in Project SMART is relevant to public health because sexual and gender minority (SGM) youth are at significantly higher risks of vaping compared with non-SGM youth in the US. The study aims to develop and test the effectiveness of a culturally responsive social media campaign to prevent initiation of electronic cigarette use (or vaping) among SGM youth between the ages of 13 and 18 years and help reduce vaping-related health disparities among vulnerable populations. This proposal directly addresses key scientific priorities of RFA-DA-21-009 to test the effectiveness of interventions to prevent initiation of vaping among adolescents.

PI_NAMEs: TAN, ANDY SL (contact)

PROGRAM_OFFICER_NAME: ROMBERG, ALEXA RUTH

PROJECT_TERMS: acceptability and feasibility;Address;Adolescent;Age;age stratification;Attitude;Behavior;Belief;Bisexual;California;cigarette smoking;cisgender;Communities;comparative effectiveness;culturally appropriate intervention;design;Development;disparity reduction;Effectiveness;effectiveness evaluation;Effectiveness of Interventions;effectiveness testing;electronic cigarette use;Ensure;Evaluation;evidence base;experimental study;Exposure to;Face;Feedback;Female;Focus Groups;Gender;Gender expansive;Gender Identity;gender minority group;gender minority youth;girls;Goals;harassment;Health;health communication;health disparity;health equity promotion;Health Promotion;Heterosexuals;High Prevalence;high risk;high school;implementation intervention;Individual;Intervention;Lesbian;Lesbian Gay Bisexual Transgender Queer;Life;Linguistics;male;Media Campaign;Media Intervention;media use;Modeling;Participant;Patient Self-Report;Peripheral;Personal Satisfaction;personalized approach;polytobacco use;Population;Predisposition;preference;prevent;primary outcome;Public Health;Qualitative Methods;Qualitative Research;Randomized;reduce tobacco use;Reporting;Research;Research Methodology;Risk;Risk Factors;Sex Orientation;Sexual and Gender Minorities;sexual debut;sexual minority group;sexual minority youth;social culture;Social Development;Social Environment;social media;Surveys;Teenagers;Testing;Tobacco;Tobacco use;transgender;United States;vaping;Vulnerable Populations;Work;Youth

PROJECT_TITLE: Project SMART: Social Media Anti-vaping Messages to Reduce ENDS Use Among Sexual and Gender Minority Teens


ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: NARRATIVE The fundamental processes of metabolism — breaking down nutrients to generate energy and using that energy to create the molecular building blocks of life — take place in a highly organized environment inside cells. In response to changes in environmental conditions many enzymes that control cellular metabolism dynamically reorganize into large assemblies that regulate and coordinate metabolic reactions. We propose to study the role of enzyme assemblies in multiple important pathways to gain insight into metabolic control, how enzyme misregulation causes disease, and how enzyme assemblies might be manipulated in new medical therapies.

PI_NAMEs: KOLLMAN, JUSTIN M (contact)

PROGRAM_OFFICER_NAME: BARSKI, OLEG

PROJECT_TITLE: Structure and function of metabolic enzyme assemblies

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


ORG_CITY: PORTLAND

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

PHR: PROJECT NARRATIVE SWOG’s clinical and translational research will lead to a better understanding of the biology underlying neoplastic disease and will ultimately enable those potentially affected by cancer to lead longer, healthier lives.

PI_NAMEs: BLANKE, CHARLES D. (contact);LARA, PRIMO N.

PROGRAM_OFFICER_NAME: MOONEY, MARGARET M

PROJECT_TERMS: Accountability;Advocate;Affect;Applications Grants;Behavior;Biology;Canada;cancer clinical trial;cancer therapy;career;Clinical;Clinical Research;clinical translation;Clinical Trials;Collaborations;Communities;cost effective;design;Development;Disease;Enrollment;Ensure;Ethics;experience;Fostering;Foundations;Funding;Future Generations;Goals;Grant;Human;Immune;improved;innovation;Knowledge;Lead;Leadership;Malignant Neoplasms;member;Mentors;Mexico;Mission;Modality;National Clinical Trials Network;NCI-Designated Cancer Center;Neoplasms;neoplastic;next generation;Oncology;operation;Pathway interactions;Patients;Persons;Physicians;Problem Solving;programs;Publishing;Regimen;Research;Research Personnel;Saudi Arabia;Science;Site;South America;South Korea;Southwest Oncology Group;standard of care;Therapeutic Trials;Time;tool;Training and Education;Translational Research;translational scientist;Translational trial;United States;United States Food and Drug Administration;Work

PROJECT_TITLE: SWOG Network Group Operations Center of the NCTN


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Patient Safety

PI_NAMEs: BLANKE, CHARLES D. (contact)

PROJECT_TERMS: adjudication;Adolescent and Young Adult;Clinical Trials;Collaborations;Collection;Communication;Contracts;Data;Data Coordinating Center;Dedications;Development;Ensure;financial conflict of interest;Funding;improved;Individual;Infrastructure;Institution;Legal;Link;meetings;member;Mission;Monitor;Occupational activity of managing finances;operation;Organizational Policy;organizational structure;patient safety;Policies;Population;Procedures;Process;process improvement;Protocols documentation;Publications;quality assurance;Records;Reporting;Research;Safety;Serious Adverse Event;Site;Southwest Oncology Group;Specimen;Speed;Structure;Tissue Banks;Training Programs;Translational trial;Work


NIH_SPENDING_CATS: Autoimmune Disease;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Epilepsy;Neurodegenerative;Neurosciences;Rare Diseases

ORG_DEPT: NEUROLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Project Narrative About 5% of focal epilepsy is associated with neural autoantibodies and may respond to immune-modulating treatment, but the diagnosis of autoimmune epilepsy remains limited to neural autoantibody testing. In this proposal, we explore novel PET and MR imaging methods that can visualize and quantify microglial activation and blood brain barrier disruption in people with definite autoantibody positive autoimmune epilepsy, and clinically suspected but antibody negative focal epilepsy. These studies may improve the diagnosis of autoimmune epilepsy, explore its neuroinflammatory mechanisms, and develop more broadly applicable markers of disease that may be used in the context of treatment.

PI_NAMEs: STERIADE, CLAUDE  (contact)

PROGRAM_OFFICER_NAME: LEENDERS, MIRIAM

PROJECT_TERMS: Aftercare;Albumins;Animal Model;Antibodies;Autoantibodies;Autoimmune;Autoimmune biomarker;Autoimmune encephalitis;Binding;Biological Markers;biomarker driven;Blood - brain barrier anatomy;Blood brain barrier dysfunction;blood-brain barrier disruption;blood-brain barrier permeabilization;Cerebrospinal Fluid;Chronic;Classification;Clinical;clinical diagnosis;Clinical Trials;cohort;Collaborations;contrast enhanced;cost estimate;Diagnosis;Diagnostic;diagnostic biomarker;Diagnostic Procedure;Disease;Disease Marker;disorder control;Encephalitis;Ensure;Epilepsy;Epileptogenesis;Etiology;Exhibits;Genetic;glial activation;Human;Image;imaging biomarker;Imaging Device;imaging modality;imaging scientist;imaging study;Immune;immunomodulatory therapies;immunoregulation;improved;Inflammation;innovation;Intervention Studies;Magnetic Resonance Imaging;Measurement;Measures;Mediating;Methodology;neural;neuroimaging;neuroinflammation;novel;Observational Study;Outcome;Partial Epilepsies;Pathologic Processes;patient population;Patients;Persons;Phenotype;Positron-Emission Tomography;Proteins;Radial;radioligand;Recovery;regional difference;Research;Seizures;Serum;Serum Albumin;Signs and Symptoms;Site;standard of care;Subjects Selections;Surrogate Markers;targeted treatment;Techniques;Temporal Lobe Epilepsy;Testing;therapeutic biomarker;tool;treatment planning;treatment response;Update;uptake;Validation;Variant;Visualization

PROJECT_TITLE: TSPO-PET and MRI Imaging as Novel Imaging Tools for Autoimmune Epilepsy

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Orthopoxviruses;Rare Diseases

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

PHR: Project Narrative To successfully replicate and disseminate in their hosts, viruses employ different strategies to manipulate the host immune responses. One such viral immune evasion strategy is the inhibition of host cell death. We have identified a viral inhibitor that targets a specific mammalian cell death pathway. We propose that this viral inhibitor not only inhibit host cell death, but also interferes with anti-viral inflammation. In this proposal, we will examine the molecular mechanism by which this viral inhibitor targets the host cell death machinery. Using mouse infection as model, we will also examine the effect of this viral inhibitor on anti-viral immune responses. The proposed study will reveal important knowledge on how viruses cause disease in human and shed light on new strategies to control viral diseases.

PI_NAMEs: MIAO, EDWARD A (contact)

PROGRAM_OFFICER_NAME: KNISELY, JANE M

PROJECT_TERMS: Apoptosis;Apoptosis Inhibitor;Binding;Biological Process;CASP8 gene;Caspase Inhibitor;Cell Death;Cell Death Inhibition;Cells;Co-Immunoprecipitations;Complex;Cowpox virus;CUL1 gene;Cullin Proteins;cytokine;Defense Mechanisms;design;Detection;Disease;domain mapping;Enzymes;Exhibits;F Box Domain;Family;Goals;Herpesviridae;Human;Immune;immune cell infiltrate;Immune Evasion;Immune response;Immune system;immunopathology;Immunoprecipitation;in vivo;Infection;Inflammation;Inflammatory;Inflammatory Response;Inhibition of NF-KB activation;inhibitor;Innate Immune Response;insight;Knowledge;Lytic;Mammalian Cell;Mediating;Medical;Modeling;Molecular;multicatalytic endopeptidase complex;Mus;mutant;NF-kappa B;novel;Orthopoxvirus;Outcome;pathogenic virus;Pathology;Pathway interactions;Pattern;Phosphotransferases;Poxviridae;Protein Kinase Interaction;Proteomics;Receptor-Interacting Protein;Recombinants;Resistance;response;RIPK3 gene;Role;Site;Small Interfering RNA;Testing;Tissues;Transfection;Ubiquitination;Vaccines;Vaccinia virus;Viral;Viral Interference;Viral Load result;Viral Physiology;Virus;Virus Diseases;Virus Inhibitors;Virus Replication;Western Blotting;Work

PROJECT_TITLE: Viral inhibition of cell death in host immune responses

STUDY_SECTION: VIRB

STUDY_SECTION_NAME: Virology - B Study Section[VIRB]


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities

PROJECT_TERMS: Advocate;Affect;American;Clinical Trials;Conceptions;cost;cost effective;Data Reporting;Development;Ensure;General Population;Goals;improved;Investments;Leadership;Life;Malignant Neoplasms;member;Mission;operation;Patients;Population;programs;Recording of previous events;Research;Research Personnel;Safety;Southwest Oncology Group;tool;Training;treatment trial


ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: Project Narrative The primary cilium is an antenna-like structure that protrudes from the cell surface. Defects in primary ciliary formation and function result in dysfunctional Hedgehog signaling, which is directly associated with human birth defects and cancers. Thus, understanding how ciliary gene mutations affect Hedgehog signaling will provide insight into the identification of potential therapeutic targets, possibly leading to the development of drugs for cilia- and Hedgehog- related human diseases.

PI_NAMEs: WANG, BAOLIN  (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TERMS: Activator Appliances;Affect;Antibodies;Binding Proteins;C-terminal;casein kinase I;Cell Differentiation process;cell fate specification;Cell Proliferation;Cell Surface Extensions;Cells;Centrioles;Centrosome;Cilia;ciliopathy;Complex;Congenital Abnormality;Cyclic AMP-Dependent Protein Kinases;Data;Defect;Development;drug development;embryo cell;Embryonic Development;Erinaceidae;Exhibits;extracellular;F-Box Proteins;Family;G-Protein-Coupled Receptors;Gene Mutation;Genes;Genetic Transcription;Glycogen Synthase Kinase 3;Goals;hedgehog signal transduction;Human;human disease;insight;Kidney;Length;Malignant Neoplasms;Mediating;Microtubules;Molecular;Mothers;multicatalytic endopeptidase complex;Mus;mutant;Mutate;Mutation;Organ;Organelles;Pathway interactions;Phenotype;Phosphorylation;Phosphorylation Inhibition;Play;Process;Proliferating;Proteins;receptor;Retina;Role;Sensory;Serine;Signal Transduction;Signaling Molecule;Signaling Protein;Site;smoothened signaling pathway;Structure;therapeutic target;Threonine;Transcription Coactivator;transcription factor;ubiquitin-protein ligase;Ubiquitination;Vertebrates;Vesicle;Zinc Fingers

PROJECT_TITLE: Understanding how ciliary gene mutations affect the processing and activity of Gli2 and Gli3 transcription factors

STUDY_SECTION_NAME: Development - 1 Study Section[DEV1]


ADMINISTERING_IC: AG

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

PHR: Overall Project Narrative Alzheimer disease (AD) has a long asymptomatic stage in which brain changes accumulate silently before finally culminating in symptoms caused by declines in memory and thinking abilities. The Knight Alzheimer Disease Research Center will coordinate and support integrated, cutting-edge transdisciplinary research initiatives to examine the mechanisms that underlie the transition from preclinical to symptomatic AD and that enhance the understanding of the pathobiological disorder.

PI_NAMEs: HOLTZMAN, DAVID M. (contact)

PROGRAM_OFFICER_NAME: SILVERBERG, NINA B

PROJECT_TERMS: Acceleration;Address;Age;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease related dementia;Amyloid;Area;Autopsy;Basic Science;Behavioral;Biological Markers;Blood;Brain;brain magnetic resonance imaging;brain tissue;career development;Cerebrospinal Fluid;Clinical;clinical center;clinical phenotype;Clinical Sciences;Cognitive;cohort;Collaborations;Communities;Consent;Data;data management;Data Set;Dementia;Dermal;design;Development;Diagnosis;Disease;disorder prevention;DNA;education research;effective therapy;Ensure;Environment;Etiology;Faculty;Fibroblasts;Financial Support;Fostering;Functional Magnetic Resonance Imaging;Funding;Genetic;Goals;Grant;Image;induced pluripotent stem cell;innovation;instrument;International;Knowledge;Memory;metropolitan;mild cognitive impairment;molecular marker;Molecular Profiling;Multicenter Studies;multidisciplinary;multimodality;National Institute on Aging;neuropathology;normal aging;outreach;Participant;Pathogenesis;Pathologic;Performance;Persons;Plasma;Population;Positron-Emission Tomography;pre-clinical;prevent;Prevention trial;Productivity;programs;Psychometrics;racial diversity;recruit;repository;Research;Research Personnel;Research Project Grants;Resources;Rest;Scientist;Services;skills;skin biopsy;statistics;student training;Students;Symptoms;tau Proteins;Thinking;Tissues;Training;transmission process;Universities;Washington;Work

PROJECT_TITLE: Alzheimer's Disease Research Center


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

PROJECT_TERMS: Advisory Committees;African American population;Alzheimer's Disease;Alzheimer's disease related dementia;Animal Welfare;Area;Collaborations;Communication;Communities;Data;data exchange;Data Set;data sharing;Development;Education;Electronics;Ensure;Faculty;Funding;Future;Goals;Human Subject Research;Individual;Leadership;meetings;Monitor;National Institute on Aging;Periodicals;Policies;Population Heterogeneity;Practice Management;programs;Public Relations;repository;Research;Research Personnel;Resource Sharing;Resources;Sampling;Schedule;senior faculty;Structure;symposium;Training;United States National Institutes of Health;Universities;Washington

PROJECT_TITLE: Administration Core


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Rare Diseases

PROJECT_TERMS: cancer clinical trial;Communication;Ensure;improved;member;Monitor;operation;Patient advocacy;Patients;rare cancer;Recruitment Activity;Research;Resources;Site;Southwest Oncology Group;Special Population;Work


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Genetics;Neurodegenerative;Neurosciences

PHR: The research aims outlined in this proposal seek to better understand the molecular pathways that contribute to neuroinflammation and neurodegeneration in Alzheimer disease (AD), which as the most common form of dementia, is a major source of human suffering and significant source of cost to the public health sector. This research has the potential to identify novel aspects of AD pathogenesis and to point to novel therapeutic targets. Ultimately, the long-term goal of these studies would be to facilitate novel treatments that could treat or prevent AD, leading to longer lives with less disability for affected patients and reduced caregiver burden.

PI_NAMEs: LONG, JUSTIN MATTHEW (contact)

PROGRAM_OFFICER_NAME: HAAKENSON, CHELSEA MARIE

PROJECT_TERMS: 25-hydroxycholesterol;Adrenoleukodystrophy;Affect;Aging;Alzheimer like pathology;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease related dementia;Alzheimer's disease risk;Amyloid;Amyloid deposition;amyloid pathology;Amyloidosis;Amyotrophic Lateral Sclerosis;Anti-Inflammatory Agents;Apolipoprotein E;apolipoprotein E-3;apolipoprotein E-4;APP-PS1;Astrocytes;Autoimmune Diseases of the Nervous System;autoimmune pathogenesis;Award;Basic Science;Biological Response Modifiers;career;career development;Caregiver Burden;Cells;cerebral amyloidosis;Cholesterol;Clinical;clinical candidate;clinical development;Clinical Research;clinical training;Coculture Techniques;Complement;cost;cytokine;Data;Dementia;Deposition;Development;Development Plans;disability;Disease;Disease associated microglia;Doctor of Philosophy;effective therapy;Ensure;Environment;Enzymes;experience;experimental study;extracellular;Faculty;Genes;Genetic;Gliosis;Goals;Human;Immune;immune activation;Inflammasome;Inflammatory;Innate Immune Response;insight;International;K-Series Research Career Programs;Knockout Mice;Laboratories;Learning;Macrophage;Mediating;meetings;Mentors;Mentorship;Methods;Microglia;Mixed Function Oxygenases;Modeling;Molecular;Motility;mouse model;Mus;Nerve Degeneration;Neurodegenerative Disorders;neurodegenerative phenotype;Neuroglia;Neuroimmune;neuroinflammation;Neurologist;Neurology;Neurons;neurotoxic;new therapeutic target;novel;Nuclear RNA;Pathogenesis;Pathologic;Pathology;Pathway interactions;Patients;Pattern;Peripheral;Phagocytes;Phenotype;Physicians;Play;Positioning Attribute;prevent;Process;Production;Productivity;Protein Isoforms;Public Health;Research;Research Personnel;Research Training;response;responsible research conduct;Role;sarkosyl;Scientist;Senile Plaques;single cell sequencing;skills;Source;Structure;tau aggregation;tau mutation;tau Proteins;Tauopathies;Testing;Therapeutic Intervention;Training;Transcript;transcriptome sequencing;transcriptomics;Transgenic Mice;Transgenic Organisms;Translating;Work;β-amyloid burden

PROJECT_TITLE: The role of 25-hydroxycholesterol in modulating ApoE-dependent Alzheimer disease-related pathogenesis

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Basic Neuroscience of Aging Study Section[NIA-N]