NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Nutrition

ORG_DEPT: CHEMISTRY

PHR: Project Narrative: Multidrug-resistant Acinetobacter baumannii and Streptococcus pneumoniae among other bacterial human pathogens, are significant threats to global human health. In this proposal, we outline a broad-based experimental strategy to significantly enhance our understanding of two regulatory processes linked to the survival of these organisms in the infected host. How bacterial cells adapt to host-mediated changes in the availability of essential transition metal nutrients and leverage hydrogen sulfide biogenesis and signaling are the focus of these studies, potentially leading to the identification of new targets for the development of novel antimicrobial therapies.

PI_NAMEs: GIEDROC, DAVID P. (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TERMS: Acinetobacter baumannii;Analytical Chemistry;Anti-Bacterial Agents;Antibiotics;antimicrobial;Antioxidants;Area;Bacteria;Biogenesis;Bioinorganic Chemistry;Biological Process;biophysical chemistry;Cells;Communicable Diseases;Consensus;design;Development;Drug Metabolic Detoxication;experimental study;Genetic Transcription;Health;Homeostasis;Human;human pathogen;Hydrogen Sulfide;Infection;innovation;Inorganic Chemistry;interdisciplinary approach;interest;Iron;Kinetics;Knowledge;Life;Link;Mass Spectrum Analysis;Mediating;metal poisoning;Methods;Microbial Physiology;Modification;Multidrug-resistant Acinetobacter;Nosocomial Infections;novel;Nutrient;Nutritional Immunity;Organism;Oxygen;pathogen;pathogenic bacteria;Pathway interactions;Positioning Attribute;Process;programs;Proteins;Proteomics;Reactive Nitrogen Species;Relaxation;Repressor Proteins;Research;respiratory pathogen;sensor;Signal Transduction;Signaling Molecule;Species Specificity;Staphylococcus aureus;Starvation;Streptococcus pneumoniae;Sulfur;Transcription Repressor;Transcriptional Regulation;Transition Elements;weapons;Zinc

PROJECT_TITLE: Transition Metal Homeostasis and Reactive Sulfur Species in Bacterial Pathogens

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-P(55)R]


ADMINISTERING_IC: AI

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Clinical Research;Infectious Diseases;Prevention;Rare Diseases;Sexually Transmitted Infections

ORG_CITY: SEATTLE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Relevance Syphilis rates in the U.S. are rising. The tests used to diagnose syphilis do not become positive until 3-5 weeks after a person becomes infected. This proposal will evaluate whether a new, molecular test for syphilis is better than older tests in diagnosing people with syphilis soon after they become infected. If the new test is superior, its adoption could lead to earlier diagnosis and treatment, thereby preventing illness in people with syphilis and transmission of the infection to others.

PI_NAMEs: GOLDEN, MATTHEW R (contact)

PROGRAM_OFFICER_NAME: GLOCK, JONATHAN A

PROJECT_TERMS: Adoption;Affect;Anatomy;Antibodies;antibody detection;antigen detection;Biological Assay;Blood;Blood Tests;Centers for Disease Control and Prevention (U.S.);Chlamydia;Clinic;Clinical;Clinical Treatment;Computerized Medical Record;Congenital Syphilis;Consent;Cross-Sectional Studies;Data;Development;Diagnosis;diagnostic strategy;diagnostic tool;Early Diagnosis;Early identification;Early treatment;Enrollment;Epidemic;Evaluation;Face;Freezing;Generations;Gonorrhea;Heterosexuals;high risk;HIV;HIV Seronegativity;HIV Seropositivity;Immunoglobulin G;Immunoglobulin M;impression;improved;Incubated;Industry;Infection;Interview;Laboratories;Lesion;Measurable;Medical;men who have sex with men;Molecular;Morbidity - disease rate;mucosal site;Mucous Membrane;Natural History;Nucleic Acid Amplification Tests;Oropharyngeal;Participant;patient screening;Patients;Persons;Pharyngeal structure;Pilot Projects;Population;Population Surveillance;pre-exposure prophylaxis;prevent;Prospective Studies;Provider;Rectum;Research;research clinical testing;Ribosomal RNA;RNA;Sampling;screening;seroconversion;Serology;Serology test;Serum;Sexual Health;Sexually Transmitted Diseases;Specimen;Study Subject;surveillance data;Swab;symposium;synthetic polymer Bioplex;Syphilis;Syphilis Serodiagnosis;Testing;tool;transcription mediated amplification;transgender;transmission process;Treponema pallidum;Urine;Vagina;Whole Blood

PROJECT_TITLE: Evaluation of a Treponema pallidum transcription mediated amplification assay for Syphilis Screening

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIB-G(90)]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Immunotherapy;Liver Disease;Organ Transplantation;Rare Diseases;Transplantation

ORG_CITY: MADISON

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PUBLIC HEALTH RELEVANCE STATEMENT Transplant recipients must take lifelong anti-rejection medications that cause side effects and decrease their ability to defend against infections and cancers. We will use a novel method of liver storage in a rat model of liver transplantation to examine the impact of interventions aimed at increasing regulatory cells within the liver, thereby making the entire organ less likely to cause an immune reaction in the recipient. This exploration of strategies to decrease patient reliance on harmful drugs holds tremendous promise not only for liver transplantation, but all solid organ transplants.

PI_NAMEs: AL-ADRA, DAVID PETER (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Acute;Affect;Animals;Anti-Inflammatory Agents;anti-PD-L1 antibodies;Belief;Biology;Biometry;career;career development;Cells;Cellular biology;Clinical;clinical practice;clinically relevant;Communication;Competence;cytokine;cytokine therapy;Dangerousness;Data;Dedications;Dendritic Cells;Development;Educational Activities;end stage liver disease;Environment;Ethics;experience;extracellular vesicles;Flow Cytometry;Foundations;Frequencies;Goals;Graft Rejection;Graft Survival;Immune;immune checkpoint;Immune response;Immune system;Immunologics;immunoreaction;immunoregulation;improved;In Vitro;in vivo;Inbred BN Rats;Infection;innovation;Interleukin-10;Intervention;Knowledge;Laboratories;Laboratory Research;Life;Liver;liver function;liver transplantation;Malignant Neoplasms;Measures;Mediating;Mentorship;Methods;Modeling;Modification;novel;Operative Surgical Procedures;Organ;Organ Donor;organ transplant rejection;Organ Transplantation;Outcome;Patients;Perfusion;Pharmaceutical Preparations;Phenotype;Physiological;Production;professor;Program Development;programmed cell death ligand 1;Property;Proteins;public health relevance;Rattus;Reaction;Research;Research Design;Research Personnel;response;Risk;Role;Scientist;side effect;skills;Solid;Surgeon;Techniques;Technology;Testing;Time;Training;Transforming Growth Factor beta;Translating;transplant model;Transplant Recipients;Transplantation;Transplantation Immunology;Transplantation Surgery;tumor-immune system interactions;Universities;Wisconsin

PROJECT_TITLE: Targeting Donor Regulatory Dendritic Cells During Normothermic Ex Vivo Liver Perfusion to Overcome Rejection after Liver Transplant

STUDY_SECTION: AITC

STUDY_SECTION_NAME: Allergy, Immunology, and Transplantation Research Committee[AITC]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: SALT LAKE CITY

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE  Mitochondria play a central role in cellular metabolism, and alterations in the function of this organelle contribute to the development of numerous human diseases. This proposal seeks to understand the regulation and function of a new cell biological pathway discovered in our lab that controls mitochondrial homeostasis in response to cellular nutrient changes. Because of the prominence of mitochondria in cellular metabolism, the proposed studies will enhance our understanding of the cellular regulation of metabolism, and provide new avenues for controlling cellular metabolic health to combat mitochondrial-associated disorders.

PI_NAMEs: HUGHES, ADAM  (contact)

PROJECT_TERMS: acid stress;Acute;age related;Amino Acids;Anabolism;Biogenesis;Biological;Carrier Proteins;cell growth regulation;Cells;Cellular Structures;combat;Cues;Cysteine;Cytoprotection;Data;Development;Disease;Functional disorder;Goals;Health;Homeostasis;Human;human disease;Impairment;Inner mitochondrial membrane;Link;Mediator;Metabolic;Metabolic Diseases;Metabolism;Mitochondria;Mitochondrial Proteins;Modeling;Nutrient;Organelles;Pathway interactions;Physiology;Play;Predisposition;Production;protective pathway;Regulation;Respiration;response;Rest;Role;sensor;Sorting;Source;Structure;System;Toxic effect;Work;Yeasts

PROJECT_TITLE: Investigating the Mitochondrial-Derived Compartment Pathway

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-T(55)R]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: HOUSTON

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: PROJECT NARRATIVE A scientific workforce well-trained in the interdisciplinary area of Pharmacological Sciences is needed to meet the increasing demand for translational researchers who can effectively address critical issues in drug development and navigate the ever-changing, interdisciplinary landscape that makes up today’s basic, translational, and clinical research. This multi-institutional training program for predoctoral students will provide interdisciplinary training in drug development including screening, computation, medicinal chemistry, and structural biology relevant to target discovery and validation, while exploring how to maximize therapeutic benefit, minimize toxicity, implement precision medicine and improve human health.

PI_NAMEs: DESSAUER, CARMEN W. (contact)

PROGRAM_OFFICER_NAME: NELSON, SHAKIRA M

PROJECT_TERMS: Pharmacology;Scientist;Training

PROJECT_TITLE: Training Interdisciplinary Pharmacology Scientists (TIPS)

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - A[TWD-A]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Health Services;Prevention;Primary Health Care

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE There are 34 million adults in the U.S. who have diabetes, and half use diabetes medications that put them at risk for having low blood sugar, a serious side effect of diabetes treatment. Doctors can help prevent this side effect by counseling patients on prevention strategies and by making changes to diabetes medications. This application will fund studies to understand how primary care doctors are communicating with patients about low blood sugar, and to develop and evaluate an intervention to help primary care doctors prevent low blood sugar more effectively.

PI_NAMEs: PILLA, SCOTT  (contact)

PROGRAM_OFFICER_NAME: ARREAZA-RUBIN, GUILLERMO

PROJECT_TERMS: Address;Adult;Area;arm;behavior change;Blood Glucose;career;career development;Caring;Chronic Disease;Clinic;clinical encounter;clinical practice;Clinical Trials;Communication;Communication Research;community based participatory research;Complex;Counseling;Data;Development Plans;Diabetes Mellitus;diabetes mellitus therapy;effective intervention;Electronic Health Record;Endocrine;Enrollment;Ensure;Environment;Event;evidence base;Evidence based intervention;Evidence based practice;experience;Frequencies;Funding;Goals;Guidelines;Health;high risk;hospital utilization;Hospitalization;Hyperglycemia;Hypoglycemia;improved;Insulin;insulin secretagogues;Internal Medicine;Interpersonal Relations;Intervention;Intervention Studies;Intervention Trial;K-Series Research Career Programs;Knowledge;Lead;Leadership;Link;Medical center;Mentors;Methodology;Methods;Modification;Morbidity - disease rate;mortality;National Institute of Diabetes and Digestive and Kidney Diseases;Outcome;Outcome Measure;Outcomes Research;Patient Outcomes Assessments;patient-clinician communication;Patients;Personal Communication;Persons;Pharmaceutical Preparations;Pilot Projects;Positioning Attribute;post intervention;prevent;Prevention;prevention practice;Prevention strategy;Preventive;preventive intervention;Primary Care;primary care practice;primary care setting;primary care visit;Process;programs;Provider;provider communication;Public Health Schools;Qualitative Methods;Qualitative Research;Recommendation;Recording of previous events;Relationship-Building;Research;Research Methodology;Research Personnel;Research Proposals;Resources;Risk;Sampling;Self Management;side effect;skills;Societies;successful intervention;Symptoms;therapy design;tool;Training;Translating;United States Department of Veterans Affairs;Visit

PROJECT_TITLE: An intervention to enhance hypoglycemia communication and preventive action in primary care

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Neurosciences;Pediatric;Racial and Ethnic Minority Health Research;Tourette Syndrome

ORG_CITY: MINNEAPOLIS

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE Tourette Syndrome (TS) is a chronic neurodevelopmental disorder that is characterized by tics, which are involuntary, repetitive movements and vocalizations. A major limitation in TS healthcare is the lack of clinical assessment measures to objectively diagnose and quantify tics and their severity, one reason that many individuals with TS go unrecognized or experience long delays in diagnosis and treatment access. In this study, we will create a large video and questionnaire dataset of N = 1,000 individuals with tics, code the videos for tic symptoms using human raters to better understand the spectrum of symptoms, and use the coded videos to train a computer algorithm to automatically detect and quantify tics.

PI_NAMEs: CONELEA, CHRISTINE A (contact)

PROGRAM_OFFICER_NAME: SIEBER, BETH-ANNE

PROJECT_TERMS: Adult;Affect;Aftercare;Agreement;Algorithms;Attention deficit hyperactivity disorder;Benchmarking;Blinking;Child;Childhood;Chronic;Classification;Clinical;Clinical assessments;clinical care;Clinical Data;clinical diagnostics;Clinical Research;Clinical Trials;clinically relevant;Code;Communities;Computational algorithm;computer science;Computer Vision Systems;Data;data acquisition;Data Set;Decision Making;Detection;Development;Diagnosis;Diagnostic;Disparity in diagnosis;Dyskinetic syndrome;Education;ethnoracial disparity;Event;experience;Eye;Face;feature extraction;Frequencies;Gilles de la Tourette syndrome;Goals;Head;Health Services Accessibility;Healthcare;Human;Individual;insight;Internet;Interview;Knowledge;Label;learning algorithm;learning strategy;Left;Machine Learning;machine learning method;Manuals;Measurement;Measures;Medical;Mental Depression;Methods;minority children;Monitor;Motor Tics;Movement;movement analysis;Neurodevelopmental Disorder;Neurology;novel;Paper;Parkinson Disease;Patient Education;patient subsets;Patients;Persons;Pharmaceutical Preparations;phenomenological models;Phenotype;Prospective cohort;prospective test;Provider;Psychiatry;Psychology;psychostimulant;Questionnaires;racial minority;Research;Sampling;screening;Severities;Shoulder;supervised learning;Symptoms;System;Techniques;Technology;Testing;tic suppression;Time;tool;Training;Underrepresented Populations;Vision research;Vocal Tics;vocalization;Work

PROJECT_TITLE: Quantification of Tics in Tourette Syndrome

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BP-R(02)M]


NIH_SPENDING_CATS: Behavioral and Social Science;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Prevention

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PROJECT NARRATIVE This proposal is to use an agent-based HIV transmission model, the HIV Calibrated Dynamic Model (HIV- CDM), to evaluate the role of the PrEP care continuum in the Getting to Zero/Ending the Epidemic (EHE) campaigns in the United States. We will expand the HIV-CDM to incorporate the behavioral, epidemic, and PrEP continuum data for men who have sex with men (MSM), men who have sex with men and women (MSMW), people who inject drugs (PWID) and heterosexuals. Using the HIV-CDM, we will model the population level impact of PrEP strategies (identification, testing, linkage, access, and retention) on the EHE goals of 50% and 90% reduction in HIV incidence over the next 5 and 10 years, respectively.

PI_NAMEs: ESCUDERO, DANIEL  (contact)

PROGRAM_OFFICER_NAME: HUEBNER, ROBIN E

PROJECT_TERMS: access disparities;Address;Adherence;AIDS prevention;Algorithms;antiretroviral therapy;Area;Awareness;Behavioral;Black Populations;black women;Boston;Calibration;Caring;Centers for Disease Control and Prevention (U.S.);Cities;Clinical;Communities;Complex;condoms;Continuity of Patient Care;Country;Couples;Data;Development;efficacy trial;Electronic Health Record;Eligibility Determination;Enrollment;Epidemic;epidemiological model;Epidemiology;evidence base;Face;Future;Goals;Guidelines;Heterosexuals;high risk;high risk population;Hispanic Populations;HIV;HIV diagnosis;HIV Infections;HIV risk;Human immunodeficiency virus test;Incidence;Injecting drug user;innovation;International;Investments;Location;Measures;men who have sex with men;men who have sex with men and women;Methods;metropolitan;Modality;Modeling;Monitor;Network-based;New York City;Phase;Policies;Policy Maker;Population;pre-exposure prophylaxis;prevent;Prevention;Prevention Guidelines;programs;Publishing;Randomized;Recording of previous events;Reporting;Research;Risk Behaviors;Role;rural setting;San Francisco;simulation;success;Testing;tool;transgender women;transmission process;United States;United States Dept. of Health and Human Services;uptake;Viral;young men who have sex with men

PROJECT_TITLE: The role of PrEP in Getting to Zero

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE This project is devoted to the development of a novel integrative, structure-based, artificial intelligence driven methodology for rapid chemical probe discovery against any target protein. The candidate molecules will be experimentally validated for three selected targets, transcription factor brachyury, hydrolase NUDT5, and bromodomain BAZ2B, and then optimized, using computational algorithms, into lead molecules to seed chemical probe development. We expect that our AI-based computational approach to convert crystallographically- determined chemical fragments into lead compounds coupled with the experimental validation of computational algorithms will accelerate the discovery of new chemical probes, expand the coverage of druggable proteome, and support future drug discovery studies.

PI_NAMEs: TROPSHA, ALEXANDER  (contact);WILLSON, TIMOTHY M

PROGRAM_OFFICER_NAME: GERSHENSON, ANNE

PROJECT_TERMS: Acceleration;Affinity;Algorithms;Antibodies;Artificial Intelligence;Binding;Binding Sites;Biological Assay;Biophysics;Brachyury protein;Bromodomain;chemical synthesis;Chemicals;Computational algorithm;computational chemistry;Computer software;Computing Methodologies;Consensus;convolutional neural network;cost;Coupled;Crystallography;Databases;design;Development;Docking;drug candidate;drug discovery;Future;Goals;Graph;Hot Spot;Human;Hybrids;Hydrolase;innovation;interest;iterative design;Laboratories;Lead;Learning;Libraries;Ligand Binding;Ligands;macromolecule;Methodology;Methods;Mining;Modeling;Modernization;Nature;novel;novel strategies;Phosphotransferases;Procedures;protein structure prediction;Proteins;Proteome;Psychological reinforcement;Resources;Roentgen Rays;scaffold;screening;Screening procedure;small molecule;small molecule libraries;Specificity;structural genomics;Structure;success;Synthesis Chemistry;Testing;transcription factor;Validation;X-Ray Crystallography

PROJECT_TITLE: Enabling the Accelerated Discovery of Novel Chemical Probes by Integration of Crystallographic, Computational, and Synthetic Chemistry Approaches

STUDY_SECTION: MSFD

STUDY_SECTION_NAME: Macromolecular Structure and Function D Study Section[MSFD]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Clinical Research;Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Substance Misuse

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Alcohol use disorder carries tremendous personal and societal costs, and in spite of best clinical efforts, this disorder is characterized by very high relapse rates following treatment. There is a pressing need for novel interventions that prevent alcohol use relapse, and help individuals achieve sustained remission. This study will develop the algorithms that will enable the biosensors embedded in commercially available smartwatches to detect stress in real time using physiological measures of autonomic arousal, which will ultimately be used to trigger smartphone relapse prevention apps to prompt patients with real-time coaching to mitigate alcohol use relapse risk.

PI_NAMEs: EDDIE, DAVID  (contact)

PROGRAM_OFFICER_NAME: KWAKO, LAURA ELIZABETH

PROJECT_TERMS: Acute;acute stress;Address;Affect;Alcohol consumption;alcohol risk;alcohol use disorder;Algorithms;Arousal;Autonomic nervous system;Award;Awareness;Bayesian Modeling;Biosensor;Cardiovascular system;career development;Cellular Phone;Chronic;classification algorithm;classifier algorithm;Clinical;clinical application;Clinical Research;Clinical Sciences;Code;cohort;Complement;Coping Behavior;Custom;Detection;detection sensitivity;deter alcohol use;Development;Devices;Disease;Disease remission;early alcohol use;Ecological momentary assessment;Electrocardiogram;Engineering;Ensure;Environment;experience;fitness;General Hospitals;Goals;health application;Health Sciences;heart rate variability;Impairment;improved;indexing;Individual;innovation;Intervention;Knowledge;Laboratories;Language;Learning;Life;Link;Machine Learning;manufacture;Manuscripts;Massachusetts;Measures;medical schools;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;mhealth interventions;Mobile Health Application;model building;Monitor;Morphologic artifacts;Motivation;negative affect;Notification;novel;Participant;Patients;Physiologic Monitoring;Physiological;Prefrontal Cortex;Preparation;Principal Investigator;Psychophysiology;real time monitoring;Recovery;reduced alcohol use;Relapse;relapse prevention;relapse risk;Research;Research Personnel;Risk;Running;Sensitivity and Specificity;Series;Signal Transduction;skill acquisition;smart watch;smartphone application;societal costs;statistics;Stress;stress management;stress reactivity;stress state;stressor;symposium;Targeted Research;Technology;Testing;therapy development;Time;time use;Training;Translating;Translations;United States National Institutes of Health;Universities;wearable sensor technology

PROJECT_TITLE: Bringing real-time stress detection to scale: Development of a biosensor driven, stress detection classifier for smartwatches

STUDY_SECTION: AA

STUDY_SECTION_NAME: Epidemiology, Prevention and Behavior Research Study Section[AA-2]


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: American Indian or Alaska Native;Arctic;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Depression;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse;Suicide;Suicide Prevention

ORG_CITY: TEMPE

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

ORG_STATE: AZ

PHR: Public Health Impact Statement The proposed study responds to a need for innovative culturally grounded parenting interventions to serve diverse urban American Indian/Alaska Native (AI) communities across the nation and address unacceptably high levels of substance use, risky sexual behavior, depression and suicidality among urban AI youth. This study will test whether a parenting intervention proven efficacious in one state is effective in distinctive and geographically dispersed urban AI communities. It will also demonstrate whether the intervention prevents youth risk behaviors through improvements in parenting skills and family functioning.

PI_NAMEs: KULIS, STEPHEN S. (contact)

PROGRAM_OFFICER_NAME: ROMBERG, ALEXA RUTH

PROJECT_TERMS: Address;Adolescent;adolescent health;Adolescent Risk Behavior;Affect;Age;Alaska Native;Alaska Native population;American Indians;Area;Arizona;behavior influence;behavioral health;Child;Child Rearing;Child Welfare;Cities;Collaborations;Communities;comparative effectiveness trial;cultural values;Death Rate;depressive symptoms;design;Education;Educational Curriculum;Effectiveness;Effectiveness of Interventions;effectiveness testing;effectiveness trial;evidence base;experience;Face;Family;Family health status;Feeling suicidal;Foundations;Geography;Health;Health behavior;health disparity;Health Services;high risk sexual behavior;Home environment;improved;Income;Individual;innovation;Intervention;intervention delivery;intervention effect;Knowledge;Lead;Link;Mediating;Mediation;medical services inaccessibility;Mental Depression;Mental Health;Midwestern United States;migration;Modeling;Morbidity - disease rate;native youth;non-Native;Nonprofit Organizations;Outcome;parent-adolescent communication;parenting intervention;Parents;Participant;Poverty;prevent;Prevention program;preventive intervention;Process;programs;Public Health;Randomized;Randomized, Controlled Trials;Recording of previous events;recruit;Reporting;Research;Research Personnel;resilience factor;Resistance;Resources;Risk;Risk Behaviors;Risk Factors;service organization;Sexual Health;Sexually Transmitted Diseases;Site;skills;social;social determinants;Social Network;Social Work;socioeconomics;Stress;stressor;Substance abuse problem;substance use;suicidal;suicidal behavior;Suicide;Testing;therapy design;Time;tribal lands;Tribes;Underserved Population;United States National Institutes of Health;Unsafe Sex;urban area;Urban Health;urban Native American;Urban Population;urban underserved;Work;Youth

PROJECT_TITLE: A multiregional RCT of Parenting in 2 Worlds for Urban Indian Families

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-V(55)]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Autoimmune Disease;Diabetes;Pediatric

ORG_CITY: GAINESVILLE

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Project Narrative  Type 1 diabetes (T1D) is an autoimmune disease characterized by autoantibody development and beta cell dysfunction prior to the immune-mediated destruction of the insulin producing beta cells of the pancreas and clinical diagnosis. The goals of this proposal are to determine the roles immune dysregulation plays in beta cell dysfunction, the mechanistic origin of the beta cell dysfunction, and whether MHC class I hyperexpression develops and causes the beta cells to be more visible to the immune system. The information gained through this proposal will be used to determine the mechanistic origin of T1D and to identify possible therapeutic targets to halt disease progression.

PI_NAMEs: HUBER, MOLLIE KATHRYN (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Academic Medical Centers;Adoptive Transfer;Age Years;Antigens;Autoantibodies;Autoimmune Diseases;Autoimmune Responses;Autoimmunity;autoreactive T cell;Beta Cell;C-Peptide;Cell Communication;Cell Death;Cell Physiology;Cell Survival;Cells;Cessation of life;clinical diagnosis;Confocal Microscopy;Coupled;Data;Development;Diabetes Mellitus;diabetes pathogenesis;Diagnosis;Disease;Disease Progression;Environment;Enzyme-Linked Immunosorbent Assay;Event;experimental study;Functional disorder;Future;Gene Expression;Generations;Glucose;glucose metabolism;glucose tolerance;Goals;Human;human tissue;Immune;immune cell infiltrate;Immune mediated destruction;Immune system;In Situ;Inbred NOD Mice;Incidence;Individual;Infiltration;inflammatory milieu;Insulin;insulin dependent diabetes mellitus onset;Insulin-Dependent Diabetes Mellitus;insulitis;Investigation;islet;Kinetics;Mediating;MHC Class I Genes;Mitochondria;Modeling;Monitor;mouse model;Mus;non-diabetic;Onset of illness;Organ Donor;Pancreas;Pathogenesis;Pathology;Pathway interactions;Patients;Pharmaceutical Preparations;Play;Population;preservation;prevent;Principal Investigator;Process;Production;protein expression;Research;Research Personnel;response;Role;Sampling;Scientist;Slice;Splenocyte;Stress;Structure of beta Cell of islet;success;T-Lymphocyte;Techniques;Testing;therapeutic target;therapy design;Time;timeline;Tissue Donors;Tissues;Training;United States;Work

PROJECT_TITLE: Investigating type 1 diabetes pathogenesis using the live pancreas tissue slice platform


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Prevention;Sleep Research;Social Determinants of Health

ORG_DEPT: PSYCHOLOGY

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

PHR: PROJECT NARRATIVE Although early interventions can improve health equity in young children living in poverty, this promise often is not realized because of barriers to family engagement. The proposed study will target co-morbid behavior and sleep problems in early childhood, comparing child outcomes and family response to sleep and behavior interventions and investigating the novel strategy of letting families select their intervention. Results will provide crucial information about how best to engage low-income families for effective early intervention to reduce behavioral and sleep health disparities in toddlers living in poverty.

PI_NAMEs: TARULLO, AMANDA  (contact)

PROGRAM_OFFICER_NAME: ESPOSITO, LAYLA E

PROJECT_TERMS: active control;Acute;Address;aged;barrier to care;Behavior;Behavior Therapy;behavioral health;behavioral health intervention;behavioral outcome;checkup examination;Child;Child Behavior;Child Health;comorbidity;design;Development;Disparity;early childhood;Early Intervention;emotion regulation;Enrollment;evidence base;Family;Functional disorder;Health;Health Benefit;health disparity;health equity;high risk;Home visitation;Household;Hygiene;improved;Income;innovation;Intervention;intervention effect;Low income;lower income families;Maintenance;Measures;Mental Health;Motivation;novel strategies;Outcome;Parents;physical conditioning;post intervention;Poverty;preference;prevent;Problem behavior;Randomized;Randomized, Controlled Trials;Reduce health disparities;response;Rest;Risk;Safety;Self Determination;Sleep;Sleep Disorders;sleep health;social stigma;socioeconomics;stressor;successful intervention;Symptoms;System;Testing;Toddler;Transact;Treatment Efficacy;trial design

PROJECT_TITLE: Advancing Engagement and Efficacy of Interventions for Co-Morbid Sleep and BehaviorProblems in Young Children


NIH_SPENDING_CATS: Genetics;Infectious Diseases

ORG_CITY: DURHAM

ORG_DEPT: GENETICS

ORG_NAME: DUKE UNIVERSITY

PHR: The goal of this proposal is to elucidate the evolutionary trajectory of the mating type locus (MAT) and how this region controls sexual development and pathogenicity of the human fungal pathogen Cryptococcus. This eukaryotic pathogen is a complex of related infectious species that are of significant global public health impact, and which infect both immunocompromised and immunocompetent individuals to cause life- threatening diseases of the lungs and brain (pneumonia, meningoencephalitis); together these species are responsible for >220,000 infections each year, and more than 181,000 deaths worldwide resulting in >15% of all HIV/AIDS associated deaths. Recent studies, including our own, have implicated auto-antibodies to the cytokine GM-CSF as a risk factor for C. gattii infections in humans, and we will employ animal models to study the impact of loss of GM-CSF signaling as a risk factor for cryptococcal infection, and assess this in the context of the distinct species in this pathogenic complex and the contributions of mating types to virulence.

PI_NAMEs: HEITMAN, JOSEPH  (contact)

PROGRAM_OFFICER_NAME: LOVE, DONA

PROJECT_TERMS: Acceleration;aerosolized;Alleles;Animal Model;Animals;Anti-sense RNA;Architecture;asexual;Autoantibodies;Award;Biology;Brain Diseases;Breeding;Centromere;Cessation of life;Chromatin Structure;Chromosomal translocation;Clustered Regularly Interspaced Short Palindromic Repeats;Code;Complex;Congenic Strain;Cryptococcus;Cryptococcus gattii;Cryptococcus neoformans;cytokine;Data;Defect;Development;dimorphism;Disease;Disease Outbreaks;Engineering;Ensure;Evolution;experimental study;Gene Cluster;Gene Expression Regulation;Generations;Genes;Genetic Recombination;Genome;genome-wide;Genomic Segment;Goals;Granulocyte-Macrophage Colony-Stimulating Factor;Growth;H19 gene;Hi-C;HIV/AIDS;Human;human pathogen;Immune;Immunocompetent;Immunocompromised Host;imprint;Inbreeding;Individual;Infection;infectious disease evolution;Inhalation;Integration Host Factors;Life;Link;low income country;Lung Diseases;Mating Types;Mating-Type Genes;Meningoencephalitis;Messenger RNA;microbial genome;Modeling;mortality;mouse model;mRNA Stability;Mus;nanopore;novel;Nuclear;organizational structure;paralogous gene;Partner in relationship;pathogen;pathogen genome;Pathogenesis;pathogenic fungus;pathogenic microbe;Pathogenicity;Patients;Plants;Play;Pneumonia;Predisposition;Prevention;Process;Production;Proteins;Public Health;Recording of previous events;Reproduction spores;Resources;Retrotransposon;Ribosomal Proteins;Ribosomes;Risk Factors;RNA;RNA Splicing;Role;Saccharomyces cerevisiae;sex;Sex Chromosomes;Sexual Development;Sexual Reproduction;Shapes;Signal Transduction;Site;Small RNA;Structure;success;System;Testing;transcriptome sequencing;transmission process;Untranslated RNA;Variant;Virulence;whole genome;Zebrafish

PROJECT_TITLE: Structure, function, and evolution of the Cryptococcus MAT locus

STUDY_SECTION: PTHE

STUDY_SECTION_NAME: Pathogenic Eukaryotes Study Section[PTHE]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Dementia;Epilepsy;Neurodegenerative;Neurosciences

ORG_CITY: LEXINGTON

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: The proposed research is relevant to public health because it is expected to advance understanding of the mechanisms underlying blood-brain barrier dysfunction in Alzheimer’s disease with epilepsy as comorbidity. The research is designed to provide a novel therapeutic intervention that repairs blood-brain barrier dysfunction to improve seizure control and reduce cognitive decline in patients that have Alzheimer’s disease with epilepsy. Thus, the proposed research is relevant to the missions of the NIH/NINDS and the NIH/NIA that pertain to developing fundamental knowledge that will help reduce the burden of neurological disease and improve the health and well-being in aging.

PI_NAMEs: BAUER, BJOERN ;HARTZ, ANIKA M.S. (contact)

PROGRAM_OFFICER_NAME: NEWMAN, ELIZABETH

PROJECT_TERMS: Acceleration;Aging;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease patient;Amyloid beta-Protein;Anticonvulsants;Attenuated;Blood - brain barrier anatomy;Blood brain barrier dysfunction;Brain;brain tissue;cerebral capillary;Characteristics;Clinical;Cognition;comorbidity;Cyclooxygenase Inhibitors;Data;design;Disease Progression;Epilepsy;Extravasation;Feedback;Functional disorder;glutamatergic signaling;Glutamates;Health;Impaired cognition;improved;in vivo;Inflammation;innovation;Intervention;Knowledge;Life Expectancy;Link;LOX gene;Matrix Metalloproteinases;Mediating;Mission;Modeling;Molecular Target;Mus;National Institute of Neurological Disorders and Stroke;Nervous System Disorder;neurovascular;novel therapeutic intervention;Outcome;Oxidative Stress;Oxidative Stress Induction;Pathway interactions;Patients;Personal Satisfaction;pre-clinical;prevent;Process;Public Health;repaired;Research;Rodent;Seizures;Signal Transduction;Testing;Therapeutic;Therapeutic Intervention;therapy design;Tight Junctions;translational potential;United States National Institutes of Health;Work

PROJECT_TITLE: Blood-Brain Barrier Repair in Alzheimer’s Disease with Epilepsy

STUDY_SECTION: BINP

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Neurosciences

ORG_CITY: NEW YORK

ORG_DEPT: NEUROSCIENCES

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: Project Narrative Although the ability of the nervous system to predict sensory input is critical for accurate perceptions, coordinated movements, and normal cognitive function, detailed accounts of the underlying neural circuitry and plasticity are lacking. This proposal addresses this challenge by applying novel experimental approaches and theoretical modeling to an advantageous model system where neural correlates for learned predictions are highly accessible to mechanistic investigation. The detailed circuit-level models we plan to develop will provide a foundation for understanding how disruptions of predictive mechanisms contribute to neurological disorders.

PI_NAMEs: ABBOTT, LAURENCE F.;SAWTELL, NATHANIEL  (contact)

PROGRAM_OFFICER_NAME: OSBORNE, LESLIE CAROL

PROJECT_TERMS: Address;Animals;autism spectrum disorder;Axon;Behavior;Behavior monitoring;Behavioral;Biological Models;Biophysics;Brain;Brain Stem;Cells;Cerebellum;cognitive function;Complex;Computer Models;Data;Dependence;Electric Fish;Electric Organ;Electrodes;Electrostatics;Environment;Feedback;Fishes;Foundations;Goals;Hippocampus;Immobilization;insight;Investigation;kinematics;Learning;Lobe;machine learning model;Measures;Methods;Modeling;Mormyridae;Motor;Movement;Nature;Neocortex;Nervous System;Nervous System Disorder;Nervous System Physiology;neural;neural circuit;neural correlate;Neuronal Plasticity;Neurons;Neurosciences;novel;Output;Pattern;Perception;Physiologic pulse;Posture;Recurrence;Resolution;Schizophrenia;Sensory;sensory input;Signal Transduction;Spinal Cord;Swimming;Synaptic plasticity;System;Testing;Theoretical model;transmission process;Work

PROJECT_TITLE: Mechanisms for Internal Models in a Cerebellum-like Circuit

STUDY_SECTION: SMI

STUDY_SECTION_NAME: Sensorimotor Integration Study Section[SMI]


ORG_CITY: Nashville

ORG_DEPT: PHYSIOLOGY

ORG_NAME: VANDERBILT UNIVERSITY

PHR: Narrative  The field of molecular endocrinology is of central relevance to multiple common human diseases, most notably obesity and diabetes. Continued progress towards understanding and curing these and many other diseases requires the training of the next generation of scientists with expertise in molecular endocrinology, which is the goal of the Molecular Endocrinology Training Program (METP).

PI_NAMEs: O'BRIEN, RICHARD M (contact)

PROJECT_TITLE: Multidisciplinary Training in Molecular Endocrinology


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF OSTEOPATHIC MEDICINE

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Depression;Dissemination and Implementation Research;Health Services;Mental Health;Mental Illness;Palliative Care;Patient Safety;Prevention;Telehealth

ORG_CITY: EAST LANSING

ORG_NAME: MICHIGAN STATE UNIVERSITY

ORG_STATE: MI

PHR: Project Narrative Use of oral anti-cancer treatment has increased significantly over the past decade for many cancers. In exchange for eliminating trip to infusion units, cancer survivors on oral agents must self-manage their symptoms at home. This project tests a highly scalable automated intervention for monitoring and managing symptoms during oral anti-cancer treatment, adding a counseling intervention for survivors in need with high psychological distress.

PI_NAMEs: BADGER, TERRY A;CRANE, TRACY E;SIKORSKII, ALLA  (contact)

PROGRAM_OFFICER_NAME: CASTRO, KATHLEEN M

PROJECT_TERMS: active control;adaptive intervention;Address;anti-cancer treatment;Antineoplastic Agents;Anxiety;anxiety symptoms;arm;attentional control;automated intervention;Cancer Survivor;care systems;Caring;Clinic;Clinic Visits;clinical practice;common symptom;Common Terminology Criteria for Adverse Events;Communities;Community Clinical Oncology Program;cost;Cost Savings;Counseling;depressive symptoms;design;Diagnosis;Dissemination and Implementation;effectiveness testing;effectiveness/implementation trial;Electronics;Emergency department visit;end of life;evidence base;Exanthema;experience;Fatigue;handbook;health service use;Home;Hospitalization;Hybrids;implementation evaluation;implementation outcomes;indexing;Infusion procedures;Interruption;Intervention;Letters;Malignant Neoplasms;Mental Depression;Minority;Monitor;multiphase optimization strategy;Multiple Cancer Sites;Nurses;Oncology;Oral;Outcome;Outpatients;Patient Outcomes Assessments;Perception;Persons;Pharmaceutical Preparations;Physicians;prevent;primary outcome;Printing;programs;Provider;psychological distress;Randomized;Reporting;Research;response;rural area;secondary outcome;Self Management;Site;Social Workers;Spanish;Supportive care;Survivors;survivorship;symptom management;symptom self management;symptomatic improvement;Symptoms;telehealth;Telephone;telephone based;Testing;Time;Toxic effect;treatment as usual;Visit;Voice;Work

PROJECT_TITLE: Managing symptoms and psychological distress during oral anti-cancer treatment

STUDY_SECTION: BMHO

STUDY_SECTION_NAME: Biobehavioral Medicine and Health Outcomes Study Section[BMHO]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Racial and Ethnic Minority Health Research

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE Black individuals have a disproportionately higher burden of insulin resistance and cardiometabolic diseases, the reasons for which are poorly understood. Neprilysin enzyme, which has increased expression in Blacks, breaks down natriuretic peptides and glucagon-like peptide-1, which are important regulators of cardiometabolic health. This study will assess the impact of neprilysin inhibition on the cardiometabolic indices in Blacks, who already have low natriuretic peptide levels and impaired postprandial glucagon-like peptide-1 response, and provide a novel therapeutic pathway for the treatment and control of the burgeoning cardiometabolic disease burden in Blacks.

PI_NAMEs: ARORA, PANKAJ  (contact)

PROGRAM_OFFICER_NAME: SCHOPFER, DAVID WESLEY

PROJECT_TERMS: Adult;Affect;Aftercare;Age;arm;Biological;Biological Markers;Black Populations;Black race;blood glucose regulation;Blood Vessels;Body mass index;Brown Fat;burden of illness;Cardiac;Cardiometabolic Disease;cardiometabolism;cohort;Data;Development;Diabetes Mellitus;disorder risk;Double-Blind Method;Endocrine system;Endocrinology;Energy Metabolism;Enrollment;Enzymes;Epidemiology;Exercise;Expenditure;experimental study;FDA approved;glucagon-like peptide 1;Glucose;Glycosylated Hemoglobin;Health;health disparity;High Prevalence;Homeostasis;Hormonal;Human;Impairment;improved;indexing;Individual;inhibitor;innovation;insulin regulation;Insulin Resistance;insulin secretion;insulin sensitivity;Intervention;intravenous glucose tolerance test;LDL Cholesterol Lipoproteins;Lipolysis;lipoprotein cholesterol;Measures;Mediating;Metabolic;Metabolism;Modeling;mortality risk;Natriuresis;Natriuretic Peptides;Neprilysin;novel strategies;novel therapeutic intervention;novel therapeutics;Obesity;Participant;Pathway interactions;patient oriented;Pharmaceutical Preparations;pharmacologic;Physiological;Population Study;primary outcome;Protocols documentation;Randomized;Randomized, Controlled Trials;Regulation;response;Rest;Role;Skeletal Muscle;Standardization;Testing;Therapeutic;treatment arm;United States Food and Drug Administration;valsartan

PROJECT_TITLE: The Effects of Neprilysin Inhibition on Cardiometabolic Health in Black Individuals

STUDY_SECTION: CCHS

STUDY_SECTION_NAME: Clinical Integrative Cardiovascular and Hematological Sciences Study Section[CCHS]


ADMINISTERING_IC: EY

ED_INST_TYPE: SCHOOLS OF OPTOMETRY/OPHT TECH

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Pediatric;Prevention;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_NAME: UNIVERSITY OF HOUSTON

PHR: Project Narrative Age related-Meibomian gland dysfunction (ARMGD) is a common eyelid disorder with a prevalence of up to 50% in the US population. Our recently published work and preliminary data show that the overexpression of hyaluronan in Meibomian glands leads to enlarged Meibomian glands and resistance to the development of ARMGD, with a striking 4-fold increase in Meibomian gland volume and an overall 10-fold increase in lipid production at 1 year of age, when compared to age-matched controls. This proposal will characterize the precise composition of the hyaluronan matrix present in Meibomian glands (Specific Aim 1), characterize how this matrix regulates Meibomian gland progenitor cells and prevents ARMGD and dry eye disease (DED) (Specific Aim 2), and allow us to develop novel strategies for treating Meibomian gland dysfunction, ARMGD and DED (Specific Aim 3).

PI_NAMEs: COULSON-THOMAS, VIVIEN JANE (contact)

PROGRAM_OFFICER_NAME: MCKIE, GEORGE ANN

PROJECT_TERMS: 1 year old;2 year old;5 year old;Age;age related;age related changes;aged;Aging;Anabolism;Atrophic;Basal Cell;Binding;Biodistribution;Biological Availability;Blurred vision;Cell Proliferation;Clinic;Clinical;Clinical Research;Complex;Data;Desiccation;design;Development;Dry Eye Syndromes;Dryness;Enzymes;Esthesia;Esthetics;Etiology;extracellular;Extracellular Matrix;Eye;eye dryness;Eyelid Diseases;Fatigue;FDA approved;General Population;Gland;gland development;HAS2 gene;HAS3 gene;Homeostasis;Human;Hyaluronan;hyaluronan synthase 1;Individual;innovation;insight;Knockout Mice;Life;Lipids;macromolecule;Medical Care Costs;meibomian gland;meibomian gland dysfunction;Modeling;Mus;novel strategies;novel therapeutic intervention;novel therapeutics;overexpression;Pain;Pathogenesis;Pathology;Photophobia;Physiological;Population;Predisposition;Prevalence;prevent;Production;Productivity;progenitor;Proliferating;Protein Isoforms;Publishing;Quality of life;Resistance;stem cell fate specification;stem cells;Stress;subcutaneous;Symptoms;Tarsal plate;Techniques;Testing;therapy development;Time;Tissues;translational potential;Treatment Protocols;United States;Up-Regulation;Wild Type Mouse;Work

PROJECT_TITLE: Modifying the extracellular matrix to prevent dry eye disease and age-related Meibomian gland dysfunction (ARMGD)

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Breastfeeding, Lactation and Breast Milk;Dental, Oral, and Craniofacial Disease;Neurosciences;Nutrition;Pediatric

ORG_CITY: STONY BROOK

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

PHR: Project Narrative  We propose to investigate the role of experience with tastants at the time of weaning on the development of taste preference in adulthood. The focus on this postnatal developmental window was chosen to determine the neural mechanism underlying gustatory experience when animals transition from relying on their mother’s milk to foraging and consuming foods. We will determine the role of GABAergic inhibitory circuits in the gustatory cortex (GC) in the postnatal development of taste preference. GC is required for taste-motivated behaviors and for learning about the chemosensory and affective dimensions of tastants, but no study to date has investigate the role of gustatory experience on the maturation of this important circuit. Successful completion of this study will provide novel insight in the contribution of early exposure to gustatory stimuli on dietary preferences in adulthood by focusing specifically on the experience-dependent refinement of neural circuits for taste perception.

PI_NAMEs: MAFFEI, ARIANNA  (contact)

PROGRAM_OFFICER_NAME: SABRI, MERAV

PROJECT_TERMS: Acute;Adolescent;Adult;Affect;Affective;Age;Animals;area striata;Auditory area;Behavioral;behavioral outcome;Blindness;Calories;Chondroitinases;Consumption;Cues;Data;design;designer receptors exclusively activated by designer drugs;Detection;Development;dietary;Dimensions;early experience;Eating;Electrophysiology (science);Exclusion;experience;experimental study;Exposure to;Extracellular Matrix Proteins;Familiarity;feeding;Food;food consumption;Food Safety;genetic manipulation;Human Milk;Immunohistochemistry;inhibitory neuron;Inhibitory Synapse;insight;Investigation;Learning;Life;motivated behavior;Mus;neural;neural circuit;neuromechanism;Neurons;novel;Nutritional;Nutritional Study;Parvalbumins;Pattern;postnatal;postnatal development;preference;Preparation;Process;Property;response;Role;Sensory;sensory cortex;sensory stimulus;Shapes;Slice;Somatosensory Cortex;Stimulus;Sucrose;Synapses;Synaptic Transmission;Taste Perception;Taste preferences;taste stimuli;Temperature;Testing;Texture;Time;Visual Cortex;Weaning;Work;young adult

PROJECT_TITLE: Cortical mechanisms for the postnatal development of taste preference.

STUDY_SECTION: NIC

STUDY_SECTION_NAME: Neuroscience of Interoception and Chemosensation Study Section[NIC]


NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: Boulder

ORG_NAME: UNIVERSITY OF COLORADO

ORG_STATE: CO

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because dysfunction of membrane trafficking pathways to the lysosome are linked to genetic disease, and exploitations of these pathways are essential for the spread of HIV-1 and other viral pathogens. Membrane trafficking pathways to lysosomes use evolutionarily conserved mechanisms. Therefore, the proposed research is relevant to the mission of NIGMS in understanding biologi- cal processes as a foundation for advances in disease diagnosis, treatment, and prevention.

PI_NAMEs: ODORIZZI, CHARLES G (contact)

PROGRAM_OFFICER_NAME: STOKES, KALYNDA K

PROJECT_TERMS: Address;Biogenesis;Biological Process;biophysical analysis;Cell Physiology;Cell Surface Receptors;Cells;Collaborations;Diagnostic;Disease;disease diagnosis;Endocytosis;Endosomes;Enzymes;extracellular;Foundations;Functional disorder;Genetic;Genetic Diseases;Genetic Screening;HIV-1;Human;In Vitro;Infection;Link;Lumen of the Lysosome;Lysosomes;man;Mediating;Membrane;Microscopy;Mission;model organism;Molecular;Mutation;National Institute of General Medical Sciences;novel;pathogen;pathogenic virus;Pathway interactions;Physiological;Prevention;Process;Productivity;Protein Analysis;Proteins;Proteomics;proteostasis;Public Health;receptor;reconstitution;Regulation;Research;Resolution;Saccharomyces cerevisiae;Saccharomycetales;Site;Sorting;System;Techniques;tool;trafficking;Ubiquitin;Vesicle;vesicle transport;Vision;Work;Yeasts

PROJECT_TITLE: Membrane trafficking to lysosomes


NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Drug Abuse (NIDA only);Mental Health;Mental Illness;Social Determinants of Health;Substance Misuse

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Project Narrative Many individuals with substance use disorders experience significant psychological distress or meet criteria for comorbid psychiatric disorders, such as mood and anxiety disorders. In this proposal we plan to examine the impact of such comorbidity on outcomes of over 5,000 patients with substance use disorders participating in 20 randomized controlled trials of pharmacological and psychosocial treatments sponsored by the National Institute on Drug Abuse. We further aim to examine how such comorbidity and its treatment changes the effect of substance use treatments these individuals receive.

PI_NAMEs: CRUM, ROSA M. (contact);MOJTABAI, RAMIN

PROGRAM_OFFICER_NAME: LYNCH, SEAN EDWARD WINTERS

PROJECT_TERMS: Abstinence;Address;analytical method;Anxiety Disorders;Behavior Therapy;Caring;Characteristics;Clinical;Clinical Trials;Cocaine;Communities;comorbidity;Criminal Justice;Data;data harmonization;Disease;Drug usage;Effectiveness;Exclusion;experience;Family;Future;General Population;Health;Health Services;Heterogeneity;improved;Individual;Investments;Legal;Measures;Medical;Mental disorders;Mental Health Services;Meta-Analysis;Methamphetamine;Methodology;Methods;Modeling;Modernization;Mood Disorders;multidisciplinary;National Institute of Drug Abuse;Observational Study;Occupational;optimal treatments;Outcome;Outcome Measure;Participant;Patient Self-Report;Patients;Pharmaceutical Preparations;pharmacologic;Placebos;psychiatric comorbidity;Psychiatric Diagnosis;Psychiatric therapeutic procedure;psychological distress;psychosocial;Randomized, Controlled Trials;reduced substance use;Research;Sample Size;Sampling;Scoring Method;screening;Services;severe mental illness;Site;social;Social Justice;Social outcome;sociodemographics;Standardization;Stimulant;Substance Use Disorder;substance use treatment;Target Populations;Techniques;Toxicology;treatment adherence;treatment arm;treatment as usual;treatment effect;Treatment outcome;treatment program;trial design;Urine;Variant;Weight;Work

PROJECT_TITLE: Substance Use Treatment Outcomes: Effect of Psychiatric Comorbidity


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

ORG_CITY: ITHACA

ORG_NAME: CORNELL UNIVERSITY

PHR: Reproductive health is not only critical for fertility and propagation of the species, but also underlies many key parameters of human health and longevity. This tri-institutional annual symposium will feature reproductive scientists, clinicians, and clinician-scientists in an informal local meeting that will facilitate collaboration and co- operation between institutions that have a strong focus on reproduction and infertility research. The emphasis of this meeting will be on trainee development and will engage neighboring institutions in order to facilitate greater communication among reproductive biologists in the Northeast.

PI_NAMEs: BARTOLOMEI, MARISA S.;COHEN, PAULA ELAINE (contact);ORWIG, KYLE EDWIN

PROGRAM_OFFICER_NAME: TAYMANS, SUSAN

PROJECT_TERMS: Advertising;Applications Grants;Area;bench to bedside;Biochemistry;career;career development;Cellular biology;Center for Translational Science Activities;Clinical;Collaborations;Communication;Communities;Connecticut;cost;Decision Making;design;Development;Distant;diversity and inclusion;Endocrine system;Endocrine System Diseases;endometriosis;Environment;Epigenetic Process;Event;experience;Faculty;Feedback;Fertility;Food;forging;Fostering;Future;Genetic;Genomics;Goals;Habitual Abortion;Health;Human;improved;Individual;Infertility;Institution;interest;International;Joints;Knowledge;Leadership;Location;Longevity;Massachusetts;meetings;Molecular;Names;National Institute of Child Health and Human Development;New Jersey;New York;Patients;peer;Pennsylvania;Personal Satisfaction;Physiological;posters;Reproduction;reproductive;Reproductive Biology;Reproductive Health;Reproductive Sciences;reproductive system disorder;Research;Research Institute;Research Personnel;Rotation;Scientist;symposium;Time;Travel;Underrepresented Minority;Underrepresented Populations;Universities;videoconference;Wine;Woman;Women's Health

PROJECT_TITLE: Tri-Institutional Symposium on Reproductive Biology & Infertility (Tri-Repro)

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Reproduction, Andrology, and Gynecology Study Section[CHHD-R]


NIH_SPENDING_CATS: Genetics;Neurosciences

ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: There is currently no effective treatment for motor neuron (MN) disorders in part due to a lack of understanding of the molecular mechanisms that allow distinct MN subtypes to acquire and maintain their function-defining properties. We recently identified several evolutionarily conserved regulatory factors (e.g., UNC-3, BNC-1, PBRM-1) that control MN subtype development and function, and the proposed research will employ cutting-edge methods to illuminate their molecular mechanism of action. Completion of these experiments will advance our understanding of how MNs become and remain functional, aiming to provide key insights into the etiology, diagnosis or treatment of MN disorders.

PI_NAMEs: KRATSIOS, PASCHALIS  (contact)

PROGRAM_OFFICER_NAME: LEE, CRYSTAL ANNE

PROJECT_TERMS: Activator Appliances;Adult;Amyotrophic Lateral Sclerosis;Auxins;Basic Science;Binding;Binding Sites;Biological Models;Brain Stem;Caenorhabditis elegans;Cell Adhesion Molecules;cell type;Cells;cholinergic;Chromatin;chromatin immunoprecipitation;Chromatin Remodeling Factor;Code;CRISPR/Cas technology;Data;Defect;Development;Developmental Delay Disorders;Diagnosis;differential expression;Disease;Ectopic Expression;effective therapy;Embryo;Endowment;Ensure;Etiology;Event;experimental study;fly;Genes;Genetic Models;Genetic Screening;Genetic Transcription;genome-wide;Goals;Human;Human Pathology;Individual;insight;Ion Channel;knock-down;Lead;Life;Light;Locomotion;Maintenance;Membrane;Methods;model organism;Molecular;Molecular Mechanisms of Action;Morphology;Motor;motor control;motor neuron development;Motor Neuron Disease;motor neuron function;Motor Neurons;Mus;Mutate;Mutation;Nematoda;Nerve;Nervous System;Neurons;Neuropeptides;Neurotransmitter Receptor;Orthologous Gene;Outcome;Predisposition;prevent;Property;Proteins;receptor;Repression;Research;Role;Secure;Spinal;Spinal Cord;Spinal Muscular Atrophy;Syndrome;System;Testing;tool;transcription factor;Transcriptional Regulation;transcriptome sequencing

PROJECT_TITLE: Molecular mechanisms of motor neuron terminal identity

STUDY_SECTION: NCF

STUDY_SECTION_NAME: Neurogenesis and Cell Fate Study Section[NCF]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Depression;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Patient Safety;Serious Mental Illness

ORG_CITY: ALBUQUERQUE

ORG_NAME: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR

ORG_STATE: NM

PHR: Electroconvulsive therapy (ECT) is the most effective therapy for adults with major depression; however, some patients fail to respond despite an adequate trial, and ECT can produce negative cognitive effects. In this revised four site, prospective study we propose the first investigation of ECT outcome integrating multiple types of data including clinical and cognitive measures, whole-brain neuroimaging, EEG, and E-field modeling to establish the mechanisms underlying ECT-induced antidepressant response (response biomarkers) and negative cognitive effects (safety biomarkers). Using this approach in patients with major depressive disorder (n = 230), we will confirm the “sweet spot” of ECT dosing in order to maximize antidepressant benefit and cognitive safety.

PI_NAMEs: ABBOTT, CHRISTOPHER C (contact)

PROGRAM_OFFICER_NAME: TILGHMAN, JESSICA IRENE

PROJECT_TERMS: Acute;Address;Adult;Adverse effects;Algorithms;Amnesia;Anatomy;anti-depressive agents;Biological Markers;biomarker identification;Blood flow;Brain;Clinical;Clinical Research;Cognitive;cognitive benefits;Collaborations;Corpus striatum structure;Data;Disease remission;Disfluent;Dissociation;Dose;effective therapy;electric field;Electroconvulsive Therapy;Electroencephalography;Ensure;Executive Dysfunction;executive function;follow-up;Functional Magnetic Resonance Imaging;Hippocampus;Image;imaging study;Impaired cognition;improved;Individual;Intervention;Investigation;Knowledge;Magnetic Resonance Imaging;magnetic resonance imaging/electroencephalography;magnetic seizure therapy;Major Depressive Disorder;Measures;Medial;meter;Methodology;Methods;Modeling;multiple data types;National Institute of Mental Health;neuroimaging;Neuronal Plasticity;noninvasive brain stimulation;Outcome;Patient-Focused Outcomes;Patients;Phenotype;Prefrontal Cortex;Process;Prospective Studies;Protocols documentation;Public Health;Research Infrastructure;response;response biomarker;Safety;Sample Size;Seizures;side effect;Site;Spottings;Standardization;Structure;System;Testing;Thalamic structure;therapy outcome;Time;verbal;Weight

PROJECT_TITLE: 2/4 Deciphering Mechanisms of ECT Outcomes and Adverse Effects (DECODE)


NIH_SPENDING_CATS: Biomedical Imaging;Drug Abuse (NIDA only);Neurosciences;Substance Misuse

ORG_CITY: BELMONT

ORG_NAME: MCLEAN HOSPITAL

PHR: Sophisticated brain imaging techniques are more frequently being used to better detect, understand, develop new medications, and track and prevent drug abuse. Since its inception 19 years ago, we have built and maintained an integrated, multidisciplinary Drug Abuse and Brain Imaging Training Program that currently supports 4 postdoctoral slots to train postdoctoral fellows how to merge imaging technologies with basic and applied clinical research and translational models of drug and alcohol abuse in order to meet these important needs. The extensive breadth of credentials of program mentors offers our trainees the best opportunity to learn to apply these skills in order to further our understanding of the neurobiological bases of the addicted brain.

PI_NAMEs: LUKAS, SCOTT E (contact)

PROGRAM_OFFICER_NAME: KAUTZ, MARY A

PROJECT_TERMS: Brain imaging;Drug abuse;Training

PROJECT_TITLE: Training in Drug Abuse and Brain Imaging


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Genetics;Lewy Body Dementia;Neurodegenerative;Neurosciences;Parkinson's Disease

ORG_DEPT: NEUROLOGY

PHR: PROJECT NARRATIVE Both α-synuclein aggregates in the brain and mutations in the gene GBA1 associate with cognitive decline in Parkinson’s disease and Dementia with Lewy bodies. The goal of this project is the determine if the lipid, glucosylsphingosine, plays a role in toxicity caused by pathologic α-syn and mutant GBA1. We will accomplish this using mouse models of mutant GBA1 and α-synuclein aggregations along with analysis of glucosylsphingosine in cortex and limbic regions from human PD-GBA1 patients.

PI_NAMEs: VOLPICELLI-DALEY, LAURA A. (contact)

PROGRAM_OFFICER_NAME: DIBATTISTA, AMANDA

PROJECT_TERMS: Age;aged;alpha synuclein;Alzheimer's Disease;Area;Attention;Behavior;Behavioral;Behavioral Assay;Biological Models;Brain;Brain region;brain tissue;Clinical Trials;Cognition;Cognition Disorders;cognitive change;Cognitive deficits;cognitive impairment in Parkinson's;Collaborations;conditioned fear;CRISPR/Cas technology;Data;deacylation;debilitating symptom;Defect;Dementia;Dementia with Lewy Bodies;Development;Diagnosis;Disease;dopaminergic neuron;enzyme activity;Enzymes;Executive Dysfunction;Exposure to;Feedback;galactosylgalactosylglucosylceramidase;Genes;Genetic Variation;glucosylceramidase;Glucosylceramides;glucosylsphingosine;Glutamates;Glycosphingolipids;Goals;Health;Heterozygote;Hippocampus;Human;human model;Impaired cognition;Impairment;Individual;inhibitor;Institutionalization;knock-down;Lewy Body Dementia;Lewy body pathology;Lipids;Lysosomes;Measures;Metabolism;Methods;monomer;Motor;motor behavior;mTOR Inhibitor;Mus;mutant;mutant mouse model;Mutation;Neurobehavioral Manifestations;Neurodegenerative Disorders;neuron loss;Neurons;neurotoxicity;novel;Parkinson Disease;Parkinson's Dementia;Parkinsonian Disorders;Pathologic;Pathology;Patients;Performance;Phenotype;Physiology;pre-formed fibril;Predisposition;prevent;promoter;Proteins;Risk;Role;Short-Term Memory;Slice;Structure;Synapses;Synapsins;synucleinopathy;TFE3 gene;Therapeutic;therapeutic target;Tissues;Toxic effect;Universities;Visuospatial;Wild Type Mouse

PROJECT_TITLE: Role of GlcSph in cognitive deficits in Lewy body dementias


NIH_SPENDING_CATS: Kidney Disease;Osteoporosis

ORG_CITY: POTSDAM

ORG_NAME: CLARKSON UNIVERSITY

PHR: NARRATIVE Dysregulation of chloride homeostasis caused by chloride channel mutations results in a significant healthcare burden, such as kidney stones (39 million people in US), Osteoporosis (10 million people in US, 43 million people in the risk group). This project will develop “organelle chemotype fingerprinting” and employ this technique to elucidate the physiological role of organellar chloride, which is essential for developing new effective treatments.

PI_NAMEs: LEUNG, KA HO  (contact)

PROGRAM_OFFICER_NAME: JUSTINOVA, ZUZANA

PROJECT_TERMS: Anions;Autophagocytosis;Calcium;Cell membrane;Cells;Chloride Channels;Chlorides;Clinical Trials;Cystic Fibrosis;Cystic Fibrosis Transmembrane Conductance Regulator;Development;effective therapy;FDA approved;Fingerprint;Fluorescence;Health;healthcare burden;Homeostasis;Human;Human body;human disease;Image;Investigation;Ions;Kidney Calculi;Measurement;Methods;Minor;Mitochondria;Mutation;Organelles;Osteoporosis;Pathway interactions;Persons;Pharmaceutical Preparations;Physiological;Play;Potassium;Proteins;Proteinuria;Reporter;Reporting;Research;Respiration;Risk;Role;Sodium;targeted therapy trials;targeted treatment;Techniques;Three-dimensional analysis;tool;Variant

PROJECT_TITLE: Development and Application of Organelle Chemotype Fingerprinting for the Functional Investigation of Organellar Chloride

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-M(55)R]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Dissemination and Implementation Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Opioid Misuse and Addiction;Opioids;Pediatric;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: PROJECT NARRATIVE More than one-third of Americans living with an opioid use disorder are publicly insured by state Medicaid or Children’s Health Insurance Plan (CHIP), but many of these state programs fail to provide sufficient access to lifesaving medications for opioid use disorder [(MOUD), i.e., buprenorphine, methadone and naltrexone] in their plan benefits. Research is critically needed to understand how policymakers overseeing Medicaid/CHIP benefit arrays solicit, receive, and use evidence to define their benefit and utilization management policies for MOUD. Aligned with NIDA’s goals to support evidence-based policies supporting substance use treatment, the proposed study will advance policy dissemination science methods to: (1) develop and administer a national survey to Medicaid/CHIP agency and MCO policymakers to identify determinants, mechanisms, and intermediaries that influence their evidence use behaviors; (2) empirically identify and describe distinct subgroups of Medicaid/CHIP agencies and MCOs based on their evidence use behaviors when designing MOUD benefits; and, (3) design and pilot test the acceptability, appropriateness and feasibility of dissemination strategies, tailored to each latent class, for promoting policymakers’ evidence-based decision-making regarding MOUD benefits.

PI_NAMEs: CRABLE, ERIKA LYNN (contact)

PROGRAM_OFFICER_NAME: WILEY, TISHA R  A

PROJECT_TERMS: 18 year old;Academy;access restrictions;Address;Adult;Advocacy;American;Authorization documentation;Behavior;behavioral health;beneficiary;Buprenorphine;career;Caring;Child;Child Health;Communication;Communities;Contracts;Data;Decision Making;design;Development;disorder prevention;Dissemination and Implementation;dissemination science;dissemination strategy;effectiveness testing;Enrollment;evidence base;FDA approved;federal policy;flexibility;Goals;Health;health inequalities;Health Insurance;Implant;implementation strategy;Improve Access;improved;Individual;Injectable;K-Series Research Career Programs;Laws;Level of Evidence;Life;Link;Managed Care;Mediator;Medicaid;medication for opioid use disorder;Mentors;Mentorship;Methadone;methadone clinic/center;Methods;Modeling;mortality;Naltrexone;National Institute of Drug Abuse;Opioid;opioid epidemic;opioid overdose;opioid use disorder;Oral;Organizational Policy;Outcome;Patients;Pediatrics;Pharmaceutical Preparations;pilot test;Policies;Policy Maker;Population;Positioning Attribute;preference;prevent;Process;programs;Public Health;Recovery;Relapse;Reporting;Research;safety net;Services;skills;Source;standard care;Statistical Data Interpretation;Subgroup;Substance Use Disorder;substance use treatment;Surveys;System;Testing;Training;United States Centers for Medicare and Medicaid Services;United States Food and Drug Administration;Youth

PROJECT_TITLE: Policy Dissemination Strategies to Improve the Use of Research Evidence in Medicaid Benefits for Opioid Use Disorder Treatment

STUDY_SECTION: SIHH

STUDY_SECTION_NAME: Science of Implementation in Health and Healthcare Study Section[SIHH]


NIH_SPENDING_CATS: Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Interstitial Cystitis;Pain Research;Urologic Diseases

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

PHR: PROJECT NARRATIVE: Interstitial cystitis/bladder pain syndrome (IC/BPS) is a severe pain condition lacking effective treatments that affects 4-12 million people in the United States. The way individuals with IC/BPS experience symptoms varies widely, and new research shows certain IC/BPS sub-groups differ in their pain and symptom presentations based on the mechanism causing their illness. To help improve treatment for IC/BPS, this project seeks to understand how IC/BPS sub-groups may respond differently to two separate therapies.

PI_NAMEs: MCKERNAN, LINDSEY COLMAN (contact)

PROGRAM_OFFICER_NAME: MULLINS, CHRISTOPHER V

PROJECT_TERMS: Affect;Affective;Aftercare;Analgesics;Behavioral;Biological Markers;Caring;central pain;Chronic;Classification;Clinical;clinical care;Clinical Management;clinical phenotype;Cognitive;cognitive benefits;Cognitive Therapy;cohort;Collaborations;cost;Coupled;cytokine;Data;Distress;effective therapy;emotional distress;Exhibits;experience;Fatigue;Future;Goals;Grouping;Growth Factor;Immunologic Stimulation;Impaired cognition;impression;Improve Access;improved;Individual;individualized medicine;Inflammation;inflammatory marker;Inflammatory Response;Institution;Interstitial Cystitis;Intervention;Intervention Studies;Medical;multidisciplinary;National Institute of Diabetes and Digestive and Kidney Diseases;neurobiological mechanism;Neurobiology;novel;Outcome;Pain;pain sensitivity;Participant;Patient Outcomes Assessments;Patients;Pelvic floor structure;Pelvic Pain;Pelvis;Peripheral;peripheral pain;Persons;Phenotype;Physical therapy;precision medicine;pressure;primary outcome;Psychology;Psychophysics;Randomized;rate of change;recruit;Reporting;Research;Research Personnel;response;Sleep;Sleep Disorders;Subgroup;Symptoms;Telemedicine;Testing;Therapeutic Intervention;Training;treatment effect;treatment planning;United States;United States National Institutes of Health;urinary;Urology

PROJECT_TITLE: Mechanistic-Based Treatment of Interstitial Cystitis/Bladder Pain Syndrome


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Clinical Research;Genetics;Human Genome;Mental Health;Mental Illness;Neurosciences;Schizophrenia;Serious Mental Illness;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: Newark

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: Project Narrative Having ascertained and clinically assessed over 65,000 participants (cases and controls) in the Genomic Psychiatry Cohort allows us the unique opportunity to study individuals with highly penetrant rare mutations that, in most cases, cause schizophrenia. We will test the hypothesis that these mutations may converge on shared pathways or targets using induced pluripotent stem cell and induced neuronal cell technologies derived from subject from the GPC with diverse genetic background. The tools and data generated herein will support the mental health field aligning with NIMH priorities, lead to transformative insights into the neurobiology of SZ, and uncover novel targets that may be a launch point for therapeutic discovery.

PI_NAMEs: HART, RONALD P;MULLE, JENNIFER GLADYS (contact);PANG, ZHIPING P.;PATO, CARLOS N

PROGRAM_OFFICER_NAME: PANCHISION, DAVID M

PROJECT_TERMS: 22q11;22q11.2;3q29;Address;Affect;African ancestry;ATAC-seq;Biological Assay;Biological Process;Biology;Cell Line;Cell Nucleus;Cell Physiology;cell type;Cells;Characteristics;Chromatin;chromosomal location;Clinical assessments;cohort;Communities;Complex;Confounding Factors (Epidemiology);Copy Number Polymorphism;Cryopreservation;Data;Delphinapterus leucas;Disease;Ectopic Expression;Ensure;excitatory neuron;Functional disorder;gamma-Aminobutyric Acid;Gene Expression;Genes;Genetic;Genetic study;genetic variant;genomic data;Genomics;Genotype;Glutamates;high risk;Human;Image;Individual;Induced Neurons;induced pluripotent stem cell;induced pluripotent stem cell technology;inhibitory neuron;insight;Investigation;Lead;Location;Lymphocyte;Mental disorders;Mental Health;mitochondrial dysfunction;Modernization;Molecular;Molecular Biology;molecular phenotype;Molecular Target;multimodality;multiple omics;Mutation;National Institute of Mental Health;Neurobiology;neuronal excitability;Neurons;Neurosciences;novel;Outcome;Participant;Pathway interactions;Penetrance;Phenotype;Physiology;Protocols documentation;Psychiatric Diagnosis;Psychiatry;psychogenetics;Psychoses;rare variant;Sampling;Schizophrenia;schizophrenia risk;sensor;single cell genomics;stem cell biology;Synapses;Synaptic Transmission;Syndrome;Techniques;Technology;Testing;Therapeutic;Time;tool;transcriptome sequencing;Underrepresented Minority;Variant;Work

PROJECT_TITLE: Cellular consequences and convergent biology of schizophrenia-associated rare variants in the diverse GPC cohort


NIH_SPENDING_CATS: Congenital Structural Anomalies;Eye Disease and Disorders of Vision;Genetics;Pediatric

ORG_DEPT: OPHTHALMOLOGY

PHR: PROJECT NARRATIVE The genetic bases of many ocular syndromes remain unresolved, due to our limit in understanding the mechanism of lens development. This study has the potential to identify the molecular mechanism of FGF signaling in orchestrating lens morphogenesis. Such an understanding will help to guide our efforts in treating ocular related birth defects.

PI_NAMEs: ZHANG, XIN  (contact)

PROGRAM_OFFICER_NAME: ARAJ, HOUMAM H

PROJECT_TERMS: Adaptor Signaling Protein;Adherens Junction;Affect;base;Binding;Cadherins;Cell Culture Techniques;Cell Differentiation process;Cell Proliferation;Child;Complex;conditional mutant;Congenital Abnormality;congenital eye disease;Cytoskeleton;Defect;Development;Diagnosis;Disease;Docking;Epithelial Cells;experimental study;Eye Development;Failure;fiber cell;Fibroblast Growth Factor;Genetic;Genetic Epistasis;Genetic Models;Goals;Grant;Health;Human;human disease;lens;Lens development;Lens Fiber;lens morphogenesis;Lens Placodes;Maintenance;Malignant Neoplasms;Mediating;Metabolic syndrome;Modeling;Molecular;Monomeric GTP-Binding Proteins;Morphogenesis;mouse genetics;mutant;Mutant Strains Mice;novel;Pathway interactions;Patients;Phenotype;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphorylation Site;Phosphotransferases;Phosphotyrosine;programs;Protein Tyrosine Phosphatase;proto-oncogene protein c-crk;Proto-Oncogene Proteins c-abl;PTPN11 gene;Receptor Protein-Tyrosine Kinases;recruit;Regulation;Role;Scaffolding Protein;SH3 Domains;Signal Pathway;Signal Transduction;Signaling Molecule;Site;Surface Ectoderm;Syndrome;Testing;transmission process;Vesicle;Vision research

PROJECT_TITLE: Signaling Mechanisms in Lens Development

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-L(02)M]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Mental Health;Pediatric;Prevention;Social Determinants of Health;Women's Health Research

PHR: PROJECT NARRATIVE Prenatal stress has devastating effects on children's neurobehavioral development, including elevating the risk for mental health disorders. What remains virtually unknown, however, is how the differential timing of prenatal stress affects the risk for later psychopathology, how this risk is mediated by children's capacity to self-regulate, and the role of the postnatal family environment in exacerbating or reducing this risk. The proposed study will provide essential information about how the timing of prenatal stress, child regulatory capacity, and the postnatal environment interact to increase risk for emerging psychopathology, which will inform strategies for developing and implementing interventions to prevent poor mental health and other negative child outcomes.

PI_NAMEs: LEVENDOSKY, ALYTIA A (contact);MUZIK, MARIA

PROGRAM_OFFICER_NAME: ESPOSITO, LAYLA E

PROJECT_TERMS: 4 year old;Address;Adolescent;Adult;Affect;Age;behavior influence;behavior observation;Behavioral;biobehavior;boys;Brain;Child;Child Behavior;Child Development;Child Rearing;Childhood;Chronic;cohort;Communities;Coping Skills;critical period;Data;Data Collection;Development;early childhood;Early Diagnosis;Environment;Environmental Risk Factor;examination questions;executive function;externalizing behavior;Family;fetal;Funding;girls;Goals;Grain;Grant;Healthcare;High Risk Woman;Impulsivity;Individual Differences;Infant;Informal Social Control;innovation;Intervention;intimate partner violence;Knowledge;Laboratories;Lead;Life;Life Stress;Literature;Machine Learning;Measures;Mediating;Mental disorders;Mental Health;Methods;Mothers;National Institute of Child Health and Human Development;negative affect;neural;neurobehavioral;novel;Outcome;Physiological;postnatal;Postpartum Period;Poverty;Predisposition;Pregnancy;prenatal;prenatal stress;Preschool Child;prevent;preventive intervention;Problem behavior;prospective;psychologic;Psychopathology;Public Health;Reporting;Research;Research Personnel;resilience;resilience factor;respiratory;Risk;Risk Factors;Role;Salivary;Sampling;sex;Sinus Arrhythmia;Stress;stress reactivity;stressor;System;Teratogens;Testing;United States National Institutes of Health;virtual;Woman

PROJECT_TITLE: Timing of prenatal stress and early markers of child psychopathology

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE The specific mediators of neuroinflammation produced by activated microglia that promote neurodegeneration in Alzheimer’s disease (AD) and related dementias (ADRD) are poorly understood. A metabolite of cholesterol that regulates lipid metabolism and promotes neuroinflammation will be examined in this proposal. Successful completion of this project may enable the development of novel therapeutic strategies towards ADRD.

PI_NAMEs: CASHIKAR, ANIL G (contact)

PROJECT_TERMS: 25-hydroxycholesterol;Acceleration;Acute;Affect;Age;age related neurodegeneration;Agonist;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease related dementia;Alzheimer's disease risk;Amyloid;Apolipoprotein E;apolipoprotein E-3;apolipoprotein E-4;Astrocytes;Brain;brain tissue;cell type;Cells;Cholesterol;cholesterol biosynthesis;Cholesterol Esters;Cholesterol Homeostasis;Cholesterol Synthesis Inhibition;Coculture Techniques;cytokine;Data;Development;Disease associated microglia;early onset;Enzymes;Esterification;Female;Functional disorder;Gene Expression;Genes;genetic risk factor;Genotype;Hippocampus;Immune;Immune System Diseases;Inflammatory;inhibitor;Late Onset Alzheimer Disease;lateral ventricle;lipid metabolism;lipidomics;Lipids;Lipopolysaccharides;longitudinal analysis;male;Measures;Mediating;Mediator;Microglia;Mixed Function Oxygenases;mouse model;Mus;Nerve Degeneration;Neurodegenerative Disorders;Neurofibrillary Tangles;Neuroglia;neuroinflammation;neuron loss;neuronal survival;Neurons;neuropathology;neurotoxicity;novel therapeutic intervention;osmotic minipump;overexpression;Pathogenesis;Pathogenicity;Pathologic;Pathway interactions;Phagocytes;Phagocytosis;piriform cortex;Play;prevent;Production;Protein Isoforms;Reporting;Role;Senile Plaques;single nucleus RNA-sequencing;SRE-2 binding protein;Stains;Synapses;tau Proteins;Tauopathies;Testing;TLR4 gene;Transgenic Mice;Transgenic Organisms;TREM2 gene;Variant

PROJECT_TITLE: Role of the microglial immune-oxysterol 25-hydroxycholesterol in mediating neuroinflammation and neurodegeneration in the P301S tau transgenic mouse model of Alzheimer's disease


NIH_SPENDING_CATS: Brain Disorders;Genetics;Neurosciences

ORG_CITY: HOUSTON

ORG_DEPT: NEUROSURGERY

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: Narrative The focal point of this project is to understand how transcription factors regulate the function of astrocytes and circuits in the brain and apply these findings to neurodegenerative diseases, including Alzheimer’s Disease. Given that astrocyte function is linked to a wide spectrum of neurological disease states, including Alzheimer’s and other neurodegenerative diseases, these studies are likely to reveal new mechanisms that can be applied to the understanding and possible treatment of these disorders. The transcription factor families we are studying NFI- and Sox- families, have been implicated in a host of neurological disorders, underscoring the direct connections between these studies and associated disease states.

PI_NAMEs: DENEEN, BENJAMIN  (contact)

PROGRAM_OFFICER_NAME: TYLER, WILLIAM A

PROJECT_TERMS: Adult;aging brain;Alzheimer's Disease;Astrocytes;Brain;Cells;Dependence;Development;Disease;epigenomics;Exhibits;Family;Family Study;Functional disorder;Genes;Genetic Transcription;Hippocampus;Knowledge;Link;Maps;member;Molecular;mouse model;Nervous System Disorder;Neurodegenerative Disorders;Neurons;NFIA gene;nuclear factor 1;olfactory bulb;Pathogenesis;Physiological;Play;Property;Proteomics;Renaissance;Role;transcription factor;transcriptomics

PROJECT_TITLE: Astrocyte Transcriptional Dependencies in Brain Circuits


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Contraception/Reproduction;Drug Abuse (NIDA only);Estrogen;Methamphetamine;Prevention;Stimulant Use and Misuse;Substance Misuse;Women's Health Research

ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because the findings will significantly advance our understanding of how natural and synthetic ovarian hormones influence methamphetamine effects and motivation to use methamphetamine. The findings will apply to a large number of US women who currently use oral contraceptives and are expected to provide a strong framework for women-focused approaches to prevention and treatment of methamphetamine and other stimulant use disorders. Thus, the project is relevant to the NIH strategic plan for women's health and sex/gender differences research, to NIDA’s Strategic Plan 2021-2025 specifically the Cross-Cutting Research Topic ‘To Understand Sex/Gender Differences’, and to NIDA’s mission to advance science on the causes and consequences of drug use and addiction and apply that knowledge to improve individual and public health.

PI_NAMEs: CHILDS, EMMA  (contact)

PROGRAM_OFFICER_NAME: MOLLICK, JESSICA ANN

PROJECT_TERMS: abuse liability;Acute;addiction;Address;Age;antagonist;Area;Biological Availability;Blood specimen;Brain;capsule;Clinical Data;Clinical Research;clinically significant;Data;Dependence;Development;Dopamine Agonists;dopamine system;Drug abuse;Drug Addiction;drug reward;Drug usage;Drug Use Disorder;efficacious treatment;Estrogens;Ethinyl Estradiol;Ethinyl Estradiol/Levonorgestrel;Exhibits;experience;Female;female sex hormone;gender difference;Goals;Gonadal Steroid Hormones;Hormonal;hormonal contraception;Hormones;improved;Individual;innovation;inter-individual variation;interest;Knowledge;Laboratories;Levonorgestrel;Life;Luteal Phase;Mediating;men;Menstrual cycle;Methamphetamine;methamphetamine effect;methamphetamine use;Methamphetamine use disorder;Midbrain structure;Mission;Motivation;National Institute of Drug Abuse;Neurobiology;Noise;novel;Oral;Oral Contraceptives;Ovarian hormone;overdose death;Participant;Pharmaceutical Preparations;Phase;pill;pre-clinical;Predisposition;Prevention;Prevention approach;Progesterone;Progestins;proliferative phase Menstrual cycle;Psychological reinforcement;Public Health;reproductive;Research;response;reward processing;Rewards;Role;Route;Schedule;Science;Self Administration;sex;Sex Differences;sigma-1 receptor;Signal Transduction;Stimulant;stimulant use disorder;Strategic Planning;Study Subject;synthetic data;Synthetic Progestogens;System;Testing;therapy development;United States National Institutes of Health;willingness;Woman;Women's Health;Work;young adult

PROJECT_TITLE: Influence of synthetic sex hormones on methamphetamine effects and self-administration in women

STUDY_SECTION: ARM

STUDY_SECTION_NAME: Addiction Risks and Mechanisms Study Section[ARM]


NIH_SPENDING_CATS: Infectious Diseases;Kidney Disease;Prevention;Urologic Diseases

ORG_CITY: COLUMBUS

ORG_NAME: RESEARCH INST NATIONWIDE CHILDREN'S HOSP

ORG_STATE: OH

PHR: Project Narrative Ascending urinary tract infections (UTIs) commonly result in pyelonephritis (PN), which can lead to clinically significant renal scarring and functional impairment. To date, the cellular mechanisms underlying the development of renal fibrosis and kidney dysfunction following PN remain unknown. Our proposed research is relevant to public health because we will identify the mechanisms by which macrophages and neutrophils mediate the development of renal scarring following PN, which will allow us to establish the foundation for new treatment paradigms to prevent loss of kidney function in patients with PN.

PI_NAMEs: RUIZ ROSADO, JUAN DE DIOS  (contact)

PROGRAM_OFFICER_NAME: RANKIN, TRACY L

PROJECT_TERMS: Acute;acute pyelonephritis;Acute Renal Failure with Renal Papillary Necrosis;Adoptive Cell Transfers;Advanced Practice Nurse;Advisory Committees;Affect;Antibiotic Therapy;antimicrobial;Area;ascending urinary tract infection;Award;Biological Assay;Biological Process;Bladder;Bladder Control;career;career development;Cells;Cicatrix;clinically significant;Complex;conditional knockout;Cystitis;Data;defined contribution;Development;End stage renal failure;Escherichia coli Infections;Fibrosis;Foundations;Functional impairment;Funding;Healthcare;Histopathology;Human;Immune;Immune response;Immunology;Impaired Renal Function;Infection;Infection prevention;Inflammation;Inflammatory;Injury to Kidney;Innate Immune Response;Innate Immune System;innovation;interstitial;Interstitial Nephritis;K-Series Research Career Programs;Kidney;kidney dysfunction;kidney fibrosis;kidney infection;Knockout Mice;long-term sequelae;Macrophage;Mediating;Mentors;Mentorship;Methodology;microbicide;Microbiology;Modeling;Molecular Biology;monocyte;mouse model;Mus;NADPH Oxidase;nephrogenesis;Nephrology;neutrophil;novel;novel therapeutic intervention;Office Visits;Outcome;oxidative damage;Oxidative Stress;Pathogenesis;Patients;Persons;Phagocytes;Phenotype;pre-clinical;Predisposition;prevent;Public Health;Reactive Oxygen Species;renal damage;Renal function;renal scarring;Research;response;Role;Scientist;Structure;Testing;therapeutic target;Training;transcriptome;United States;Urinary tract infection;Uropathogenic E. coli

PROJECT_TITLE: Contrasting roles for neutrophils and macrophages during acute pyelonephritis

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

NIH_SPENDING_CATS: Brain Disorders;Drug Abuse (NIDA only);Substance Misuse

PHR: 1. PROJECT NARRATIVE Estimates from NIDA established that pre-pandemic costs associated with drug misuse and addiction, including harms to individuals, families and society, exceeded $600 billion annually; these are likely to have increased sharply during the pandemic, given the massive increase in opioid overdose deaths alone. Thus, the nation needs a workforce equipped to impact the modifiable risk and protective factors for substance misuse and addiction, particularly among vulnerable populations including racial, ethnic, sexual and gender minorities. Through a mentoring team approach, TranSTAR aims to train future addictions researchers to work across disciplinary boundaries, to produce translatable, rigorous and reproducible research that will inform services to, treatment of, clinical correlates of and policies affecting populations vulnerable to substance use disorders and co-occurring and comorbid conditions.

PI_NAMEs: CAVAZOS-REHG, PATRICIA A;GOLDBACH, JEREMY THOMAS (contact)

PROGRAM_OFFICER_NAME: HIGHSMITH, KEISHER S

PROJECT_TERMS: addiction;Research;Training

PROJECT_TITLE: Transdisciplinary Training in Addictions Research

STUDY_SECTION: NIDA

STUDY_SECTION_NAME: Career Development Education and Training Study Section[NIDA-S-K]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Infectious Diseases;Primary Immunodeficiencies;Rare Diseases

ORG_CITY: SAN FRANCISCO

ORG_DEPT: DERMATOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative Hidradenitis Suppurativa (HS) is a prevalent and debilitating disease that results from chronic skin inflammation. Experiments in this grant application will discover why the immune system is chronically activated in the skin of HS patients. In addition, we will determine if enhancing specific immune cells that suppress inflammation can effectively treat this disease. Our results will help establish new therapeutic approaches for patients with HS.

PI_NAMEs: ROSENBLUM, MICHAEL DAVID (contact)

PROGRAM_OFFICER_NAME: UNDALE, ANITA H

PROJECT_TERMS: Abnormal Cell;Acceleration;Affect;Affinity;Age;Animal Model;Applications Grants;Attenuated;Basic Science;Binding;Biological Assay;Biological Models;Biopsy Specimen;Caring;Cell Compartmentation;Cell Lineage;Cell Physiology;Cell Separation;Cell Surface Receptors;Cells;Cellular Assay;Chronic;chronic inflammatory disease;chronic inflammatory skin;Clinic;Cutaneous;Data;Dedications;Defect;Development;Disease;effective therapy;Epigenetic Process;Equilibrium;Evaluation;experience;experimental study;Fibrosis;Flow Cytometry;Foundations;Functional disorder;Gender;Genetic Transcription;Hair follicle structure;Health;Hidradenitis Suppurativa;High Prevalence;Homeostasis;Human;humanized mouse;IL17 gene;Immune;Immune response;Immune system;Immunology;immunopathology;in vivo;Infiltration;Inflammation;Inflammatory;Inflammatory Infiltrate;innovation;interdisciplinary approach;Interleukin 2 Receptor;Interleukin-2;Laboratories;Lesion;Mediating;Medical;member;Modeling;Molecular;Morbidity - disease rate;mouse model;multidisciplinary;Mus;neutrophil;novel;novel strategies;novel therapeutic intervention;OX40;Pathogenesis;Pathologic;Pathology;Pathway interactions;Patients;Phenotype;Play;Proteins;Psoriasis;Regulatory T-Lymphocyte;Research Personnel;response;Role;Signal Transduction;single-cell RNA sequencing;Sinus;Site;Skin;skin biopsy;skin disorder;skin fibrosis;skin lesion;skin organogenesis;Testing;Therapeutic;Tissues;tool;Translational Research;translational study;treatment strategy;Tumor Necrosis Factor Receptor;Validation

PROJECT_TITLE: Restoring Immune Balance in Hiddradenitis Suppurativa


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences;Nutrition

PHR: Project Narrative Body weight is regulated by neural circuits that track food intake and trigger satiety. While these circuits have long been studied using many approaches, their natural activity patterns during a meal are almost completely unknown. Here we propose to apply approaches from systems neuroscience and physiology to define how these key neural circuits that control satiety are dynamically regulated in mice.

PI_NAMEs: KNIGHT, ZACHARY A. (contact)

PROGRAM_OFFICER_NAME: COOKE, BRAD

PROJECT_TITLE: Neural Dynamics Underlying Feeding

STUDY_SECTION: POMD

STUDY_SECTION_NAME: Pathophysiology of Obesity and Metabolic Disease Study Section[POMD]


NIH_SPENDING_CATS: Brain Disorders;Chronic Pain;Drug Abuse (NIDA only);Neurosciences;Opioid Misuse and Addiction;Opioids;Pain Research;Substance Misuse

ORG_CITY: TUCSON

ORG_NAME: UNIVERSITY OF ARIZONA

PHR: NARRATIVE  In our work we’ve found that Heat shock protein 90 (Hsp90) has a crucial role in regulating opioid signaling in brain and spinal cord. We’ve further found that isoform-selective Hsp90β inhibitors can enhance the potency of morphine to control acute and chronic pain, while reducing tolerance and leaving constipation and reward unchanged. In this proposal we will thus develop optimized Hsp90β inhibitors based on our KUNB106 scaffold; this will result in a drug that could be given to humans in order to reduce the doses of opioid needed to control pain, resulting in fewer side effects, most notably tolerance and addiction.

PI_NAMEs: STREICHER, JOHN MICHAEL (contact)

PROGRAM_OFFICER_NAME: HILLERY, PAUL

PROJECT_TERMS: ABCB1 gene;Absence of pain sensation;Acute Pain;addiction;Affect;Affinity;Analgesics;analog;antinociception;aqueous;Binding;Binding Proteins;Biological Availability;Brain;Chronic;chronic pain;chronic pain management;Clinical;Constipation;cost;Crystallization;Cytochrome P450;Data;Dependence;Development;Dose;Drug Kinetics;Drug usage;Fluorescence Polarization;Generations;Goals;Health;Heat-Shock Proteins 90;HIV;HSP 90 inhibition;Human;improved;In Vitro;in vivo;in vivo evaluation;Individual;inhibitor;Investigation;Lead;Liver Microsomes;MDCK cell;Medical;meter;Methods;Microsomes;Modern Medicine;molecular modeling;Morphine;morphine tolerance;mu opioid receptors;Mus;Neuropathy;novel;novel drug class;novel strategies;novel therapeutics;opiate tolerance;Opioid;opioid abuse;Opioid Analgesics;opioid epidemic;Opioid Receptor;opioid therapy;Oral;Oral Administration;Overdose;Oxycodone;Pain;Pain management;pain model;patient population;Patients;Performance;Permeability;Persons;Pharmaceutical Chemistry;Pharmaceutical Preparations;Plasma;Plasma Proteins;Play;Protein Isoforms;Proteins;Public Health;Quality of life;Receptor Signaling;Regulation;response;Rewards;Role;scaffold;side effect;Signal Transduction;small molecule;social;Solubility;Spinal;Spinal Anesthesia;Spinal Cord;Structure;Surgical incisions;Tail;Techniques;Testing;Therapeutic;Toxic effect;Toxicity Tests;United States;Ventilatory Depression;Work

PROJECT_TITLE: Development of Hsp90 Isoform- Selective Inhibitors as a Novel Opioid Dose-Reduction Therapy

STUDY_SECTION: DDNS

STUDY_SECTION_NAME: Drug Discovery for the Nervous System Study Section[DDNS]