NIH_SPENDING_CATS: Autoimmune Disease;Chronic Pain;Diabetes;Genetics;Neurodegenerative;Neurosciences;Nutrition;Obesity;Pain Research;Peripheral Neuropathy

ORG_CITY: RICHARDSON

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF TEXAS DALLAS

PHR: PROJECT NARRATIVE: PUBLIC HEALTH RELEVANCE With obesity and diabetes affecting a large percentage of the US population and the increased occurrence of associated pain states; studies on pain, diet, diabetes, and inflammation are critical. The objective of the proposed experiments is to understand if direct activation of sensory neurons or adjacent macrophages is the culprit in TLR4-specific diabetic neuropathic pain development. The results of the studies will resolve a highly contended theory in the field and undoubtedly lead to a paradigm shift to our approach on therapeutics for diet- induced and diabetic neuropathic pain.

PI_NAMEs: BURTON, MICHAEL D (contact)

PROGRAM_OFFICER_NAME: SERRANO, KATRINA JANE

PROJECT_TERMS: Affect;Afferent Neurons;Agonist;Alleles;Animals;antinociception;Automobile Driving;Biochemical;Biological Assay;Calcium;cell type;Cells;chronic neuropathic pain;chronic pain;Development;Diabetes Mellitus;diabetic;Diabetic Neuralgia;Diet;diet-induced obesity;dietary;Dietary Component;Dietary Factors;Dietary Fats;Dietary Sugars;dimorphism;Disease;Disparate;Dissociation;Electrophysiology (science);experimental study;Fatty acid glycerol esters;Female;Foundations;Gene Expression;Gene Modified;Gene Proteins;Generations;Genetic;genetic technology;Goals;High Fat Diet;HMGB1 gene;Image;in vivo;Incidence;Individual;Inflammation;Inflammatory;innovation;insight;Knock-out;Lead;LoxP-flanked allele;Macrophage;Maintenance;male;Mediating;Methods;Molecular;Mus;Nervous System;Neurons;Neuropathy;new therapeutic target;Nociception;nociceptive response;Nociceptors;Nonesterified Fatty Acids;novel;novel therapeutic intervention;novel therapeutics;Obesity;Pain;Pain Measurement;pain relief;painful neuropathy;Paper;Pathology;Patients;Pattern;Peripheral;Peripheral Nervous System;Peripheral Nervous System Diseases;Persons;pharmacologic;Phenotype;Physiological;Play;Population;Prevention;Production;programs;public health relevance;Publishing;Pyruvaldehyde;receptor;Reporting;Research;Resistance;response;Rodent Model;Role;Saturated Fatty Acids;Sensory;Signal Transduction;Source;Streptozocin;System;theories;Therapeutic;therapeutic target;TLR4 gene;tool;Transgenic Organisms;Unhealthy Diet;United States;western diet;Work

PROJECT_TITLE: The role of cell-specific TLR4 in Diabetic Peripheral Neuropathy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-P(54)]


ADMINISTERING_IC: EB

ARRA_FUNDED: N

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Racial and Ethnic Minority Health Research;Wound Healing and Care

ORG_CITY: MIAMI

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_FIPS: US

ORG_NAME: FLORIDA INTERNATIONAL UNIVERSITY

ORG_STATE: FL

PHR: PROJECT NARRATIVE Assessing wounds from a subclinical physiological perspective is a novel addition to smartphone-based technologies that augment mobile health (mHealth) point-of-care wound management, potentially predicting serious complications early on, and triage diabetic foot ulcers (DFUs) with high-risk lesions for clinical care. In addition, the development and validation of a smartphone-based optical device that performs physiological imaging (based on oxygen to wounds) apart from visual imaging across any skin tone and foot curvatures make the technology applicable across different racial/ethnic groups.

PI_NAMEs: GODAVARTY, ANURADHA  (contact)

PROGRAM_OFFICER_NAME: LASH, TIFFANI BAILEY

PROJECT_TERMS: 3-Dimensional;Adopted;African American population;Amputation;Assessment tool;Beer;Caring;Caucasians;Cellular Phone;Characteristics;Chronic;Chronic Care;Clinical;Clinical assessments;clinical care;Clinics and Hospitals;Collaborations;Communities;Complications of Diabetes Mellitus;computer science;Development;Devices;Diabetes Mellitus;Diabetic Foot Ulcer;Discipline of Nursing;Ethnic Origin;Ethnic Population;Excision;Florida;flu;foot;Functional Imaging;global health;healing;health care delivery;high risk;Hispanic Americans;Hospitalization;Image;Image Analysis;imaging approach;Imaging technology;in vivo;Incidence;innovation;International;Laws;Lesion;Light;Limb structure;machine learning algorithm;Maps;Measurement;mHealth;Modeling;multidisciplinary;mutant;Native Americans;Near-infrared optical imaging;Noise;novel;Optics;Outcome;Oxygen;pandemic disease;Patients;Persons;Physiological;Pigmentation physiologic function;point of care;Positioning Attribute;preservation;racial difference;racial population;Research;Research Design;Risk;Signs and Symptoms;Site;Skin;skin color;skin wound;SMART health;statistics;Surface;Surgeon;Technology;tissue mapping;tissue oxygenation;tissue phantom;Tissues;tool;Triage;Validation;validation studies;Variant;Visual;wound;wound care;wound treatment

PROJECT_TITLE: Smartphone-based optical scanner to physiologically assess diabetic foot ulcers

STUDY_SECTION: ITD

STUDY_SECTION_NAME: Imaging Technology Development Study Section[ITD]


ADMINISTERING_IC: FD

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: BALTIMORE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: Narrative Statement We propose continuation of M-CERSI that fosters FDA-oriented research, as well as regulatory science information sharing opportunities. The Center's mission is to foster the development of regulatory science – the science of developing new tools, standards and approaches to assess the safety, efficacy, quality and performance of FDA-regulated products. Activities leverage the close geographic proximity between University of Maryland and FDA's main campus.

PI_NAMEs: BENTLEY, WILLIAM E.;POLLI, JAMES E (contact)

PROGRAM_OFFICER_NAME: SEPULVEDA, KRISTIN

PROJECT_TITLE: University of Maryland Center of Excellence in Regulatory Science and Innovation


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: PROJECT NARRATIVE The Johns Hopkins CERSI (JH-CERSI) represents a highly innovative collaboration between the world’s leading regulatory authority and the country’s largest research university. In this renewal, we combine the remarkable success of JH-CERSI since its inception with three new elements to accelerate knowledge and enhance impact in areas of incredibly high regulatory importance. There is not a moment to lose.

PI_NAMEs: ALEXANDER, G. CALEB (contact)

PROGRAM_OFFICER_NAME: BATTLES, JESSICA JOY

PROJECT_TITLE: Johns Hopkins Center of Excellence in Regulatory Science and Innovation


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Congenital Heart Disease;Congenital Structural Anomalies;Heart Disease;Heart Disease - Coronary Heart Disease;Hypertension;Lung;Nutrition;Obesity;Pediatric;Rare Diseases;Sleep Research

ORG_CITY: COLUMBIA

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

ORG_STATE: MO

PHR: Project Narrative Obstructive sleep apnea (OSA) is a chronic condition that can lead to heart attacks. The currently unknown impact of OSA on the coronary arteries of the heart in female and obese OSA patients and the contribution of mineralocorticoid receptor activation, which is known to cause cardiovascular disease, will be characterized using a mouse model of sleep apnea. This will permit development of treatments for OSA patients to prevent coronary heart disease

PI_NAMEs: BADRAN, MOHAMMAD  (contact)

PROGRAM_OFFICER_NAME: FLEG, JEROME L

PROJECT_TERMS: Acceleration;Adjuvant Therapy;Air;Aldosterone;Animals;antagonist;Area;Atherosclerosis;Blood;Blood Pressure;blood pressure reduction;Blood Vessels;Cardiac;Cardiovascular Diseases;cardiovascular risk factor;Cardiovascular system;Cells;Chronic;Clinical Trials;clinically significant;Collagen Fiber;Continuous Positive Airway Pressure;Coronary;Coronary artery;Coronary heart disease;Coronary Vessel Anomalies;Coronary Vessels;Data;diet-induced obesity;dietary control;Echocardiography;Endothelial Cells;endothelial dysfunction;Endothelium;Euthanasia;experimental study;Exposure to;Fasting;Fatty acid glycerol esters;Female;gene network;Goals;Heart;heart function;Hour;Human;Hypertension;Hypoxia;Impairment;improved;improved outcome;in vivo;Incidence;indexing;Inflammation;innovation;insight;Insulin Resistance;intimal medial thickening;Left;Link;Lipids;male;Mediating;Metabolic;Methods;Microvascular Dysfunction;Mineralocorticoid Receptor;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;Myocardial Infarction;new therapeutic target;Non obese;normoxia;novel;Obese Mice;obese person;Obesity;Obstructive Sleep Apnea;Outcome;Oxidative Stress;Patients;Persons;Placebos;Play;Population;prevent;Process;Protocols documentation;receptor;Receptor Activation;Receptor Inhibition;Receptor Signaling;Recovery;Renin-Angiotensin-Aldosterone System;Rest;Risk;Role;sex;Signal Transduction;single nucleus RNA-sequencing;Sleep;Sleep Apnea Syndromes;Smooth Muscle Myocytes;Source;Spironolactone;System;Tail;Telemetry;Testing;Therapeutic Intervention;therapeutic target;therapy development;Thinness;Tissues;Transgenic Mice;treatment adherence;Treatment Efficacy;vascular contributions;Vascular Diseases

PROJECT_TITLE: Coronary artery dysfunction in OSA: Role of mineralocorticoid receptors

STUDY_SECTION: TDPS

STUDY_SECTION_NAME: Therapeutic Development and Preclinical Studies Study Section[TDPS]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Genetics;Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: PHILADELPHIA

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

ORG_STATE: PA

PHR: Microcephaly, and disorder, division abnormal smallness of the head, is caused by genetic mutations, viral infections maternal substance abuse. To prevent or ameliorate this devastating neurodevelopmental the proposal will study pathogenic mechanisms associated with the abnormal cell of neural progenitors.

PI_NAMEs: KIM, SEONHEE  (contact)

PROGRAM_OFFICER_NAME: RIDDLE, ROBERT D

PROJECT_TERMS: Abnormal Cell;Actomyosin;Apical;Binding;Biogenesis;brain size;Cannibalism;cell behavior;cell cortex;Cell Death;Cell Nucleus;Cell Survival;Cells;Cerebral cortex;Complex;Cre driver;Cytokinesis;Defect;Disease;DNA Sequence Alteration;Event;Gene Expression;Genes;Genetic;Genetic Models;genome integrity;Genomics;Head;Hippocampus;Human;Image;insight;Knowledge;Length;Maintenance;Microcephaly;Mitosis;Mitotic;Molecular;molecular asymmetry;Morphology;mouse model;mutant;Mutation;Myosin ATPase;neoplastic cell;nerve stem cell;Neuroepithelial;Neuroglia;Neurons;novel;Pathogenicity;Pathology;Phenotype;prevent;Process;Production;progenitor;protein complex;Proteins;Radial;Regulation;rho;Side;Signal Transduction;stemness;Structure;Substance abuse problem;Surface;Tertiary Protein Structure;Testing;Time;TP53 gene;tumorigenic;Ventricular;Virus Diseases

PROJECT_TITLE: Regulation of Cortical Progenitor Mitosis

STUDY_SECTION: NCF

STUDY_SECTION_NAME: Neurogenesis and Cell Fate Study Section[NCF]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;Emerging Infectious Diseases;Infectious Diseases;Tickborne Diseases;Vector-Borne Diseases

ORG_CITY: BOSTON

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: HARVARD MEDICAL SCHOOL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Babesia species are thick-borne intracellular parasites that infect the red blood cells of their mammalian host, causing severe to fatal diseases called babesiosis. Novel and effective drugs against Babesia parasites are needed, given its increasing worldwide distribution and the lack of a vaccine to treat this illness. This proposal aims to determine the structure of apicoplast ribosomes from B. divergens.

PI_NAMEs: LEGER-ABRAHAM, MELISSA  (contact)

PROGRAM_OFFICER_NAME: MCGUGAN, GLEN C

PROJECT_TERMS: Address;Affinity;Affinity Chromatography;Animal Diseases;Animals;Anti-Bacterial Agents;antibiotic design;Antibiotics;Antiparasitic Agents;Apicomplexa;Area;Babesia;Babesiosis;Binding;Biology;climate change;Clinical;Complex;Cryoelectron Microscopy;Cytoplasm;Cytoplasmic Structures;Cytosol;design;Development;Disease;Drug resistance;Elements;Erythrocytes;Event;experience;experimental study;Fever;forest;Foundations;Gene Expression;Gene Expression Regulation;Geographic Distribution;Geography;Goals;Growth;Hemagglutinin;Human;human disease;Immune system;Immunocompromised Host;improved;Individual;Infection;Inorganic Phosphate Transporter;Laboratories;Life;Life Cycle Stages;Malaria;Membrane;Methods;Mitochondria;Molecular;Molecular Biology;Molecular Structure;Names;NMR Spectroscopy;novel;novel therapeutics;Organelles;Organism;Parasites;particle;Pathway interactions;Pharmaceutical Preparations;Plasmodium;Plasmodium falciparum;posttranscriptional;Preparation;Property;Protein Biochemistry;Protein Biosynthesis;Protocols documentation;Public Health;rational design;Relapse;Research Proposals;Resolution;Ribosomal Proteins;Ribosomal RNA;Ribosomes;structural biology;Structure;suburb;Symptoms;targeted agent;targeted treatment;Therapeutic Intervention;Thick;tick-borne;Tick-Borne Diseases;Toxoplasma;Toxoplasmosis;Translations;Vaccines;Work;X-Ray Crystallography

PROJECT_TITLE: Ribosome structure determination from Apicomplexan parasites

STUDY_SECTION: MSFC

STUDY_SECTION_NAME: Macromolecular Structure and Function C Study Section[MSFC]


ORG_CITY: NEW HAVEN

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: 8. PROJECT NARRATIVE The Centers of Excellence in Regulatory Science and Innovation (CERSI) program allows the U.S. Food and Drug Administration (FDA) to form extramural partnerships that foster robust and innovative research to develop new tools, standards, and approaches to assess the safety, efficacy, quality, and performance of FDA- regulated products, supporting regulatory decision-making and the overall mission of the FDA. Over the past seven years, the Yale-Mayo Clinic CERSI has pursued a series of innovative research projects that leverage real-world data sources to assess the safety, efficacy, quality, and performance of FDA-regulated products, informing regulatory decision-making as well as manufacturers, clinicians, and patients in support of optimizing patient-centered care, along with providing and supporting high-quality mentorship and training in regulatory science. The Yale-Mayo Clinic CERSI will continue this work, conducting high-quality, high-impact regulatory science research in priority areas identified by the FDA to modernize development and evaluation of FDA- regulated products, strengthen post-market surveillance and labelling of FDA-regulated products, and invigorate public health preparedness and response of FDA, patients, and consumers.

PI_NAMEs: ROSS, JOSEPH SOLOMON (contact)

PROJECT_TITLE: Yale-Mayo Clinic FDA Center of Excellence in Regulatory Science and Innovation (CERSI)


NIH_SPENDING_CATS: Biotechnology;Immunization;Infectious Diseases;Malaria;Rare Diseases;Vector-Borne Diseases

ORG_CITY: BETHESDA

ORG_NAME: HENRY M. JACKSON FDN FOR THE ADV MIL/MED

PHR: PROJECT NARRATIVE Despite over a half a century of effort, no effective vaccines have been developed against malaria, which still causes in over 450,000 deaths a year, primarily in children. The proposed study examines the development and maturation of the humoral immune responses following sequential parasite exposures. The findings will be used to design understand the development of immunity to facilitate the design of more effective vaccines.

PI_NAMEs: ROTH, ALISON ELIZABETH;WILLIAMSON, KIM C (contact)

PROGRAM_OFFICER_NAME: PESCE, JOHN T

PROJECT_TERMS: Accounting;acquired immunity;Address;Adult;Affinity;Animals;Antibodies;Antibody Formation;Antibody Repertoire;Antibody-mediated protection;Antigens;Appearance;Area;B-Lymphocytes;Biological Assay;Bite;Blood;CD19 gene;Cell Separation;Cells;Cessation of life;Child;Clinical;Clinical Trials;Clonal Expansion;cofactor;Collaborations;Communicable Diseases;Country;Culicidae;cytokine;Data;design;Detection;Development;Disease;Environment;Erythrocytes;Exposure to;Fever;Future;Generations;Genetic Polymorphism;Goals;Growth;Hepatocyte;Human;Humoral Immunities;Immune response;Immunity;Immunoglobulins;Immunophenotyping;In Vitro;in vitro Assay;Individual;Infection;Invaded;Legal patent;Liver;Malaria;malaria infection;Memory;Memory B-Lymphocyte;Micro Array Data;Modeling;Monitor;multiplex assay;Natural Immunity;Parasite Control;Parasitemia;Parasites;Pattern;Peptides;Peripheral Blood Mononuclear Cell;Persons;Plasma;Plasma Cells;Plasmablast;Plasmodium;Plasmodium falciparum;Population;Predisposition;Production;Proliferating;Recombinants;reduce symptoms;response;Role;Sequence Analysis;single cell sequencing;single-cell RNA sequencing;Sorting;Sporozoites;Time;vaccine development;Vaccines;Virulent;Virus Diseases;volunteer;Work

PROJECT_TITLE: Maturation of human humoral immunity through repeat malaria challenges

STUDY_SECTION: CMIB

STUDY_SECTION_NAME: Cellular and Molecular Immunology - B Study Section[CMIB]


NIH_SPENDING_CATS: Cardiovascular;Genetics;Heart Disease

ORG_CITY: FARMINGTON

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT

PHR: Heart failure is a syndrome of major public health significance. An estimated 6.2 million Americans are currently suffering from heart failure, and this number is estimated to increase 46% by 2030. A better understanding of the molecular mechanism underlying cardiac remodeling, including pathological myocyte hypertrophy, should significantly help in the design of new therapeutics for treatment, thereby decreasing patient mortality.

PI_NAMEs: DODGE-KAFKA, KIMBERLY L (contact)

PROGRAM_OFFICER_NAME: SCHWARTZ, LISA

PROJECT_TERMS: A kinase anchoring protein;Adverse effects;American;beta-adrenergic receptor;Binding;Biological Assay;Biosensor;Calcineurin;calcineurin phosphatase;Calmodulin;Cardiac;Cardiac Myocytes;Cell Physiology;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Computer Models;Coupling;Cyclic AMP;Cyclic AMP-Dependent Protein Kinases;Cytosol;Data;Dedications;Dependovirus;design;Development;Dimensions;Disease;Fluorescence Resonance Energy Transfer;Gene Expression;gene induction;Gene Transduction Agent;Genetic Transcription;Goals;Heart Diseases;Heart failure;Heart Hypertrophy;Human;Hypertrophy;in vivo;Individual;Induced Cardiomyocytes;inhibitor;insight;Ion Channel;Length;light microscopy;live cell imaging;Maps;Mediating;Modeling;Molecular;mortality;mouse model;Muscle;Muscle Cells;Mutation;novel;novel therapeutic intervention;novel therapeutics;Nuclear;Nuclear Envelope;nuclear factors of activated T-cells;Organelles;Pathologic;Pathway interactions;Patients;Phosphorylation;Phosphorylation Site;Photobleaching;Physiology;polypeptide;pressure;prevent;Prevention;Process;Protein phosphatase;Public Health;Receptor Signaling;recruit;Regulation;response;Role;Ryanodine Receptor Calcium Release Channel;Sarcoplasmic Reticulum;Scaffolding Protein;Second Messenger Systems;segregation;sensor;Series;Signal Pathway;Signal Transduction;Site;Source;Specific qualifier value;Specificity;Structure;Syndrome;Testing;Therapeutic;tool;transcription factor;Transcriptional Activation;Treatment Failure;treatment strategy;Visible Radiation

PROJECT_TITLE: Perinuclear Ryanodine Receptors and Cardiac Remodeling

STUDY_SECTION: BBHV

STUDY_SECTION_NAME: Basic Biology of Blood, Heart and Vasculature Study Section [BBHV]


NIH_SPENDING_CATS: Antimicrobial Resistance;Digestive Diseases;Infectious Diseases;Lung;Microbiome;Pneumonia;Pneumonia and Influenza;Prevention

ORG_CITY: WINSTON-SALEM

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

ORG_STATE: NC

PHR: NARRATIVE Klebsiella pneumoniae infections are a growing threat to human health. This application will address mechanisms of acquisition, carriage, pathogenesis, and host resistance. Our results our expected to lead to preventative strategies and therapeutic interventions to combat Klebsiella pneumoniae-associated disease.

PI_NAMEs: HAAS, KAREN M (contact);ZAFAR, MUHAMMAD AMMAR

PROGRAM_OFFICER_NAME: ERNST, NANCY L

PROJECT_TERMS: Affect;Animal Model;Antibiotic Resistance;Antibiotics;Antibodies;Automobile Driving;B-Lymphocytes;Bacteria;Bar Codes;Blood;Blood Circulation;Cardiovascular system;colonization resistance;combat;Data;deep sequencing;Development;Disease;Disease Progression;disorder control;dysbiosis;epidemiologic data;Epithelium;Event;Exhibits;experience;experimental study;Feces;Frequencies;gastrointestinal;Gastrointestinal tract structure;Growth;gut colonization;gut microbiome;Health;healthcare-associated infections;host microbiota;Host resistance;Hour;Human;humoral immunity deficiency;Immune;Immune system;Immunocompetent;Immunocompromised Host;immunodeficiency;Immunoglobulins;improved;Individual;Infection;innovation;Integration Host Factors;Intervention;intestinal epithelium;Klebsiella pneumoniae;Knowledge;Life;Liver;Mediating;microbiome;Modeling;Molecular;mortality;mouse model;Mucous Membrane;Mus;Oral cavity;Organ;pathogen;Pathogenesis;Pathway interactions;Patients;Pattern;Play;Polymeric Immunoglobulin Receptors;Population;Population Dynamics;Predisposition;prevent;Prevention;Prevention strategy;Probiotics;Public Health;Publishing;reconstitution;Resistance;resistant Klebsiella pneumoniae;Resolution;Role;Sampling;Sepsis;Site;Spleen;Sterility;Surface;Systemic infection;Therapeutic Intervention;Time;Tissues;Wild Type Mouse;Work

PROJECT_TITLE: Role of B cells in controlling Klebsiella pneumoniae associated disease states

STUDY_SECTION: IHD

STUDY_SECTION_NAME: Immunity and Host Defense Study Section[IHD]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Project Narrative It has never been more important to create and maintain a cadre of PhD and physician-scientists engaged in translational research in lung disease and critical illness. Given the unprecedented developments at the cellular and molecular level, including knowledge of the human genome, we are now poised for unprecedented progress in translation of this new knowledge base to the study of the pathophysiology, prevention and treatment of human disease. Investment and innovation in the training and career development of this class of new investigators is greatly needed and will prepare future researchers for the unique challenges associated with advancing science and public health in the realm of pulmonary and critical care medicine.

PI_NAMEs: WARE, LORRAINE B (contact)

PROGRAM_OFFICER_NAME: KALANTARI, ROYA

PROJECT_TERMS: Clinical;Pulmonology;Training Programs

PROJECT_TITLE: Clinical and Translational Training Program in Pulmonary Medicine

STUDY_SECTION: NITM

STUDY_SECTION_NAME: NHLBI Institutional Training Mechanism Study Section[NITM(OA)]


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Genetics;Neurosciences;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: Los Angeles

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

ORG_STATE: CA

PHR: The current proposal exploits foundations of neuroscience to advance our understanding, through the perspective of the neural microenvironment the development of one of the most common and deadliest childhood brain tumors: medulloblastoma (MB)-- interplay which remains poorly understood and studied. We hypothesize that medulloblastoma will exploit an enzyme called ABAT used to breakdown the neurotransmitter GABA, one of the most abundant molecules in their microenvironment, for growth and spread. These studies will have potential near-term impact on understanding how the pediatric brain tumor MB is formed and uncover ABAT overexpressing tumor cells as a target to treat MB metastasis – the principal reason for MB-induced mortality.

PI_NAMEs: ERDREICH-EPSTEIN, ANAT ;NEMAN-EBRAHIM, JOSH  (contact)

PROGRAM_OFFICER_NAME: FOUNTAIN, JANE W

PROJECT_TERMS: 4-Aminobutyrate aminotransferase;Amino Acid Sequence;ATAC-seq;BARHL1 gene;Biological;Biological Assay;Blood - brain barrier anatomy;blood-brain barrier crossing;blood-brain barrier permeabilization;Brain;Cell Nucleus;Cells;Cerebellum;Cerebrospinal Fluid;Cessation of life;Characteristics;Child;Childhood Brain Neoplasm;Childhood Malignant Brain Tumor;Chromatin Structure;Cisplatin;comparison control;Competence;Control Animal;Cytoplasmic Granules;Data;Development;Disease;Energy-Generating Resources;Enzymes;Epigenetic Process;Foundations;gamma-Aminobutyric Acid;Gene Activation;Genetic Markers;Genetic Transcription;Goals;Growth;Histone Acetylation;Histone Deacetylase;Histone H3;Human;human induced pluripotent stem cells;Immunoprecipitation;In Vitro;in vivo;inducible gene expression;inhibitor;knock-down;Leptomeninges;Lesion;Life;Lysine;Malignant Neoplasms;Maximum Tolerated Dose;Medulloblastoma;Metabolic;Metabolism;Metastatic Neoplasm to the Leptomeninges;Mitochondria;Modification;mortality;mouse model;Mus;Neoplasm Metastasis;neoplastic cell;nerve stem cell;Nervous System;neural;Neurobiology;neurodevelopment;Neuroglia;Neurons;Neurosciences;Neurotransmitters;novel;novel therapeutic intervention;Nuclear;Nutrient;Oncogenes;Outcome;overexpression;Paper;Pathogenesis;Patients;Pharmaceutical Preparations;Phenotype;Primary Neoplasm;Proliferating;protein H(3);Publishing;radiation resistance;receptor;Receptor Activation;Reporting;Research;Role;Route;Shunt Device;Signal Transduction;Site;small molecule;Spectrum Analysis;standard of care;stem cell differentiation;Therapeutic;therapeutic target;Toxic effect;transcriptome;transcriptome sequencing;Transgenic Mice;tumor;tumor microenvironment;tumorigenic;Vincristine;Xenograft procedure

PROJECT_TITLE: The Role of GABA Transaminase ABAT in Pediatric Brain Tumor Medulloblastoma Development and Spread

STUDY_SECTION: TEHM

STUDY_SECTION_NAME: Tumor Evolution, Heterogeneity and Metastasis Study Section[TEHM]


NIH_SPENDING_CATS: Lung

ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: PROJECT NARRATIVE The development of allergic inflammation in the airways depends upon cytokines that are secreted by various cell types in the lung to orchestrate the inflammatory process. This is dependent upon cells that respond to those cytokines. In this proposal we define an alternative receptor for one of those cytokines that is present on non-hematopoietic cells.

PI_NAMEs: KAPLAN, MARK H (contact)

PROGRAM_OFFICER_NAME: MINNICOZZI, MICHAEL

PROJECT_TERMS: Acute;airway epithelium;Allergic Disease;Allergic inflammation;Autoimmune Diseases;Autoimmunity;Binding;Biochemical;Biological Assay;Biological Models;Biology;Cell Communication;cell type;Cells;Chronic;Communication;Complex;cytokine;Cytokine Receptor Binding;Cytokine Receptors;Data;Development;Dimerization;Disease;Epithelial Cells;Erythropoietin;Exposure to;Family;flexibility;Gene Activation;Gene Expression;Gene Targeting;Hematopoietic;IL-13Ralpha1;IL7 gene;immune function;Immune response;Immunity;In Vitro;in vivo;in vivo Model;Inflammation;Inflammatory;insight;Interleukin 2 Receptor;Interleukin-15;Interleukin-2;interleukin-21;Interleukin-4;Interleukin-9;intestinal epithelium;Knowledge;Left;Lung;Mediating;Mediator;Modeling;Mus;Mutant Strains Mice;Organ;patient population;Patients;Process;Proliferating;protein activation;Pulmonary Inflammation;receptor;Reporting;response;Signal Pathway;Signal Transduction;Smooth Muscle Myocytes;STAT protein;Structure;Testing;Tracheal Epithelium;Tumor Immunity

PROJECT_TITLE: Defining a type II IL-9R


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Mental Health;Neurodegenerative;Neurosciences

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative: This project seeks to adapt existing supported decision-making tools for use in AD/ADRD and to assess whether it is feasible to implement supported decision making in a clinical setting. This intervention development research will further our understanding of interventions that could be broadly implemented in clinical settings to promote effective dyadic- and triadic- communication and improve wellbeing for patients and their care partners.

PI_NAMEs: LARGENT, EMILY  (contact)

PROGRAM_OFFICER_NAME: GERALD, MELISSA S

PROJECT_TERMS: Address;Adoption;Adult;Affect;Age;Agreement;Alzheimer's Disease;Alzheimer's disease related dementia;American;Appointment;Attitude;Behavior Therapy;Behavioral Model;Belief;Bioethics;Caring;Clinical;clinical encounter;Collaborations;Communication;Conflict (Psychology);Consensus;Consent;Decision Making;Development;Elder Abuse;Elements;Ensure;Ethicists;Family member;Fostering;Freedom;Goals;Health;help-seeking behavior;Impairment;improved;Individual;innovation;insight;Intellectual functioning disability;Intention;Intervention;intervention delivery;Interview;Legal Guardians;Logic;Measures;Medical;medical appointment;Memory;Methods;mild cognitive impairment;Minor;Modification;neglect;novel;older adult;Outcome;Parents;Patients;Personal Satisfaction;Persons;pilot test;Process;Readability;Reporting;Research;research and development;Research Methodology;Resources;Role;Self Determination;Self Efficacy;shared decision making;Specific qualifier value;Structure;Supervision;therapy development;tool;Training;treatment as usual;United States National Institutes of Health;Vulnerable Populations;Work;young adult

PROJECT_TITLE: Adapting supported decision making to promote wellbeing and improve health outcomes for persons living with Alzheimer's disease and Alzheimer's disease related dementias


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Mental Health;Mental Illness;Neurosciences;Pediatric;Psychosis;Schizophrenia;Serious Mental Illness

ORG_CITY: LA JOLLA

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Narrative Despite significant advances in our understanding of the clinical high risk (CHR) for psychosis state, the longer-term outcomes (5+ years) and the trajectory of diagnoses, symptoms and psychosocial function have been seldom investigated in this population. Substantial evidence already exists for multiple biomarker abnormalities in CHR subjects that predict psychotic conversion but it is not known whether biomarkers predict longer term (>5 years) conversion and functional outcomes. Longer-term follow-up of up to 2000 CHR individuals identified over the last 20 years provides a unique and rare opportunity to investigate the full trajectory of illness in both those individuals who developed psychosis and those who did not.

PI_NAMEs: CADENHEAD, KRISTIN S. (contact)

PROGRAM_OFFICER_NAME: MORRIS, SARAH ELIZABETH

PROJECT_TERMS: Adolescence;Affective;Affective Symptoms;Age;Anxiety;Biological Markers;Brain;Characteristics;Chronic;Chronic Disease;Clinical;clinical high risk for psychosis;comorbidity;Data;design;Development;Diagnosis;Diagnostic;diagnostic criteria;Disease;Disease remission;duration of untreated psychosis;emerging adult;EP300 gene;Event-Related Potentials;Female;first episode psychosis;follow-up;Functional impairment;functional outcomes;Future;Gender;gray matter;high risk;high risk population;Hydrocortisone;Impairment;improved;in utero;Individual;inflammatory marker;insight;Link;meetings;Meta-Analysis;Modeling;Moods;Neurocognition;Neurocognitive;Neurocognitive Deficit;Neurodevelopmental Disorder;non-affective psychoses;Onset of illness;Outcome;outcome prediction;Parents;Participant;Pathologic;Persons;Phase;polygenic risk score;Population;Population Heterogeneity;predictive marker;prospective;Psychoses;psychosis risk;psychosocial;psychotic;Psychotic Disorders;psychotic symptoms;Research;Retrospective Studies;Risk Factors;Role;Schizophrenia;social;substance use;Symptoms;Syndrome;Testing;Time;Trauma;white matter;Youth

PROJECT_TITLE: Predictors and Moderators of Long-Term Outcome of Persons at Clinical High Risk for Psychosis

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Chronic Pain;Infectious Diseases;Neurosciences;Pain Research;Psoriasis

ORG_CITY: PITTSBURGH

ORG_DEPT: DERMATOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative Cutaneous sensory neurons, in particular pain-sensing nociceptors, are required for the development of inflammation in skin in both patients and mouse models. Using mouse models, our goal is to fully delineate the pathway(s) that link neurons with the development of local inflammation. We expect that this basic mechanistic understanding will provide benefit to patients with autoimmune skin disease and those suffering from chronic pain.

PI_NAMEs: KAPLAN, DANIEL H (contact)

PROGRAM_OFFICER_NAME: UNDALE, ANITA H

PROJECT_TERMS: Ablation;adaptive immunity;Affect;afferent nerve;Atopic Dermatitis;Autoimmune;Autoimmune Diseases;Autoimmunity;autoinflammatory diseases;Candida albicans;Cell Degranulation;Cell model;cell type;Cells;Cellularity;chemokine;chronic pain;Chronic small plaque psoriasis;Complex Regional Pain Syndromes;Contact hypersensitivity;Cutaneous;cutaneous sensory neurons;cytokine;Data;Dendritic cell activation;Dendritic Cells;Dermal;Dermis;designer receptors exclusively activated by designer drugs;Development;Disease;expectation;extracellular;Feedback;Flare;Genetic;Goals;Grant;Hidradenitis;Hidradenitis Suppurativa;Host Defense;IL17 gene;Imiquimod;Immune;immune function;Immunity;Immunologics;Infection;Inflammation;Inflammatory;Innate Immune Response;insight;Interleukin-1 beta;Interleukin-13;interleukin-23;Interleukin-4;Interleukin-6;Ion Channel;Irritant Dermatitis;Kinetics;Lasers;Light;Link;Maintenance;mast cell;Mediating;Memory;Modeling;Monitor;mouse model;Mus;Nerve;neuroinflammation;Neurons;Neuropeptides;Nociceptors;optogenetics;Organ;Pain;Papain;Papillary;Parasites;pathogen;Pathogenicity;Pathway interactions;Patients;Play;Production;Psoriasis;Pyroglyphidae;Reflex action;response;Role;Site;Skin;skin disorder;Staphylococcus aureus infection;Stimulus;T cell response;T-Lymphocyte;Testing;Therapeutic Intervention;Time;Tissues;TRPV1 gene;Work

PROJECT_TITLE: Immune Functions of Cutaneous Nociceptors

STUDY_SECTION: ACTS

STUDY_SECTION_NAME: Arthritis, Connective Tissue and Skin Study Section[ACTS]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences;Opioids;Substance Misuse

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

PHR: This proposal addresses the need for more effective pharmacotherapies to treat alcohol use disorder (AUD). Our previous findings have implicated the brain nociceptin/orphanin FQ (N/OFQ) neuropeptide receptor (NOP) as a treatment target for AUD. This project employs a translationally oriented approach to establish therapeutic potential of a novel pharmacological agent that, like the major AUD therapeutics currently in use, blocks classical opioid receptors but also activates NOP receptors and, therefore, may provide superior treatment efficacy.

PI_NAMEs: WEISS, FRIEDBERT  (contact)

PROGRAM_OFFICER_NAME: EGLI, MARK

PROJECT_TERMS: Acute;addiction;Address;Agonist;Alcohol abuse;Alcohol consumption;alcohol intervention;alcohol preferring rats;alcohol relapse;alcohol use disorder;Alcoholic Intoxication;Amygdaloid structure;Animals;antagonist;Area;Attenuated;Behavior;behavior test;Brain;Brain region;Chronic;comparative efficacy;Consumption;craving;Data;Dependence;design;Development;drug action;Foundations;Funding;Genetic;innovation;Intake;Investigation;Knock-out;Lead;Link;Measures;Mediating;Minority;Modeling;motivated behavior;Motivation;nalmefene;Naltrexone;neural;Neurobiology;Neuropeptide Receptor;nociceptin;novel;Opioid;Opioid Antagonist;Opioid Receptor;overexpression;Patients;Pharmaceutical Preparations;pharmacologic;Pharmacotherapy;preference;Psychological reinforcement;Rattus;receptor;Receptor Activation;receptor function;Receptor Up-Regulation;receptor upregulation;Recording of previous events;recruit;Relapse;relapse prevention;Research;Rest;Rewards;Shapes;Site;Solid;standard of care;Stress;System;Therapeutic;transmission process;Treatment Efficacy;Up-Regulation;Ventral Tegmental Area;Wistar Rats;Workload;Yohimbine

PROJECT_TITLE: The Nociceptin ORL1 System: Treatment Target for Relapse

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Social Determinants of Health

ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: Project Narrative The proposed education program is relevant to public health because it increases the pipeline of diverse researchers interested in the behavioral, sociological, biological, and clinical aspects of brain aging as well as Alzheimer’s disease and related dementias. To improve the health and overall wellbeing of older adults, it is imperative to address minority health disparities in vulnerability to dementia and other common comorbidities of advanced age. One way to address these disparities is to recruit more individuals from minority and/or disadvantaged backgrounds to diversify the research workforce and ensure that early career researchers and pre-health professionals develop and appreciation for aging and have access to resources, meeting the NIA mission of fostering the development of research and clinician scientists in aging. .

PI_NAMEs: ABISAMBRA, JOSE FRANCISCO;ALVINA, KARINA ;BURKE, SARA N (contact)

PROGRAM_OFFICER_NAME: LUO, YUAN

PROJECT_TERMS: Address;Aging;aging brain;Alzheimer's disease related dementia;Area;Automobile Driving;Awareness;Bachelor's Degree;Behavioral;Biological;Black race;Brain;bridge to the baccalaureate;career;Clinical;clinical training;Cognitive;Cognitive aging;Collaborations;Communication;Communities;comorbidity;Data Analyses;Dementia;disadvantaged background;Disease;Disparity;Disparity population;Diverse Workforce;Doctor of Philosophy;Education;Educational Status;Educational workshop;Elderly;Ensure;experience;Experimental Designs;Florida;Fostering;Funding;Goals;hands on research;Health;health disparity;health inequalities;Health Professional;Healthcare;Impaired cognition;Impairment;improved;Inequality;Inequity;innovation;Institution;interest;Laboratories;Laboratory Research;Latina;Latino;Latinx population;matriculation;Measurable;meetings;member;Mentors;Mentorship;Minority Groups;minority health disparity;minority undergraduate;Mission;Native Americans;Neurobiology;Not Hispanic or Latino;older adult;Outcome;Participant;Patient Self-Report;Personal Satisfaction;Population;Postbaccalaureate;Process;programs;Public Health;randomized, clinical trials;recruit;Reduce health disparities;Research;Research Activity;research and development;Research Personnel;Research Training;Resources;Risk;Schools;Scientist;skills;Sociology;Students;summer research;Training;Training and Education;Training Programs;undergraduate research;undergraduate student;Underrepresented Minority;United States National Institutes of Health;Universities

PROJECT_TITLE: Networking and Expanding Undergraduate Research on the Neurobiology of Aging to Advance Diversity


NIH_SPENDING_CATS: Antimicrobial Resistance;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Infectious Diseases

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: The UNAIDS has set ambitious “90-90-90” targets and the goal of eliminating HIV by 2030: To achieve this goal, and to eventually end the HIV epidemic, simple, safe, effective, potent and inexpensive ARV-regimens will be needed as well as effective tools for point-of care monitoring. The planned rollout by the Senegal National AIDS Program of 1st-line dolutegravir-based ART with a generic, single table regimen of tenofovir-lamivudine- dolutegravir (TLD) has the potential to improve HIV-2 and HIV-1/HIV-2 dually infected patient outcomes and achieve the UNAIDS 90-90-90 targets. Evaluation of the outcomes of TLD rollout for HIV-2 in Senegal, West Africa will help ensure its promise as novel public health intervention and serve as a model for the region.

PI_NAMEs: GOTTLIEB, GEOFFREY SCOTT (contact)

PROGRAM_OFFICER_NAME: CRAWFORD, KEITH W

PROJECT_TERMS: acceptability and feasibility;Acquired Immunodeficiency Syndrome;Adverse event;Africa;Anti-Retroviral Agents;antiretroviral therapy;arm;Biological Assay;Capsid;Caring;CD4 Lymphocyte Count;Central Africa;Cessation of life;Clinic;Clinical;clinical decision-making;Clinical Research;Clinical Trials;Collaborations;comorbidity;comparative;cost estimate;Death Rate;detection assay;Devices;Diagnosis;diagnostic assay;Discrimination;Drug resistance;drug testing;Effectiveness;Enrollment;Ensure;Epidemic;Europe;Evaluation;experience;Failure;Generations;Genotype;Goals;Guidelines;HIV;HIV diagnosis;HIV drug resistance;HIV Infections;HIV serology;HIV-1;HIV-2;Home;Human immunodeficiency virus test;implementation trial;improved;Infection;inhibitor;Integrase;Lamivudine;Lopinavir/Ritonavir;Modeling;Monitor;Multi-Drug Resistance;next generation;non-nucleoside reverse transcriptase inhibitors;novel;Nucleic Acids;Outcome;Participant;Pathway interactions;Patient Care;Patient-Focused Outcomes;Patients;Persons;Phenotype;point of care;Predisposition;primary endpoint;programs;public health intervention;Recording of previous events;Regimen;Research;Resistance;resistance mechanism;resistance mutation;Resource-limited setting;Sample Size;secondary endpoint;Senegal;Serology;Site-Directed Mutagenesis;Tablets;Tenofovir;Testing;tool;translational study;Treatment Protocols;uptake;Validation;Viral;viral detection;Viral Load result;Visit;Work

PROJECT_TITLE: Improving Diagnosis, Treatment & Detection of Drug Resistance in HIV-2 Infection

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: TUCSON

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: PROJECT NARRATIVE Expeditious diagnosis and effective treatment are essential for the positive long-term outcomes for patients with Cushing’s Disease (CD). Effective treatment of recurrence of disease remains a challenging task for endocrinologists and neurosurgeons. The proposed research will allow us to identify novel therapeutic approaches to effectively treat ACTH-secreting pituitary adenomas in patients with CD by targeting the tumor directly.

PI_NAMEs: LITTLE, ANDREW SCOTT;ZAVROS, YANA  (contact)

PROGRAM_OFFICER_NAME: MALOZOWSKI, SAUL N

PROJECT_TERMS: Acceleration;adenoma;Adrenal Glands;Anxiety;Arizona;Automobile Driving;Biochemical;BRAF gene;Cardiovascular Diseases;CDH23 gene;Cell Culture Techniques;Cell Differentiation process;Cell Line;Cell Lineage;Cells;Cellular biology;Cessation of life;Chemicals;Chronic;Clinic;clinical practice;Confocal Microscopy;Corticotropin;Data;Data Analyses;Development;Diabetes Mellitus;Diagnosis;digital;Disease;Disease remission;drug repurposing;Drug Screening;effective therapy;Endocrine System Diseases;Endocrinologist;Exhibits;experience;Exposure to;Flow Cytometry;follow-up;Funding;Genes;Goals;Growth;Health;Hormone secretion;Human;Hydrocortisone;Hypopituitarism;illness length;Immune;improved;In Vitro;induced pluripotent stem cell;Lead;Link;Malignant Neoplasms;Medical;Mental Depression;Modeling;Molecular Profiling;Morphology;mortality risk;Mus;Mutation;nano-string;Neuroendocrine Tumors;Neurologic;Neurosurgeon;novel;novel therapeutic intervention;Obesity;Operative Surgical Procedures;Organoids;Pathogenesis;Pathologic;Pathology;patient tolerability;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;Pituitary Diseases;Pituitary Gland;Pituitary Gland Adenoma;Pituitary Neoplasms;Pituitary-dependent Cushing's disease;Population;Positioning Attribute;Pre-Clinical Model;prevent;Production;Proliferating;Quality of life;Radiosurgery;Rattus;Recurrence;Recurrent disease;Recurrent tumor;Research;Resected;Resistance;response;Risk;Route;screening;Signal Pathway;spheroids;standard of care;Standardization;stem cell expansion;stem cells;Stroke;Stromal Cells;Study models;Surgeon;targeted treatment;Technology;Therapeutic;therapy development;three dimensional cell culture;Time;tissue/cell culture;Tissues;Training;transcriptome;transcriptomics;Translating;tumor;Tumor Pathology;Tumor Subtype;Tumor-Derived;Universities;USP8 gene

PROJECT_TITLE: Development and Standardization of a Novel Pituitary Adenoma Organoid Model for the Study and Treatment of Cushing's Disease

STUDY_SECTION: CMT

STUDY_SECTION_NAME: Cellular and Molecular Technologies Study Section[CMT]


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Back Pain;Behavioral and Social Science;Chronic Pain;Clinical Research;Mental Health;Neurosciences;Pain Research;Prevention;Sleep Research

ORG_CITY: TEMPE

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

PHR: PROJECT NARRATIVE Given that pain research has historically focused on the occurrence of one chronic pain condition at a time, little is known about the evolution of multiple, co-occurring pain conditions. The proposed study will seek to address this important issue and knowledge gap, as well as provide insight into whether sleep and circadian rhythm disturbances are the underlying catalysts in the progression from a single to multiple chronic pain conditions. Key findings of the proposed study can inform development of novel intervention and/or prevention approaches to improving the care of millions of adults with multiple chronic pain conditions.

PI_NAMEs: MUN, CHUNG JUNG  (contact)

PROGRAM_OFFICER_NAME: GREENWELL, THOMAS

PROJECT_TERMS: 6-sulfatoxymelatonin;actigraphy;Acute;Address;Adult;Affect;Anatomy;Anxiety;body map;burden of illness;Caring;catalyst;Chronic;Chronic Headaches;Chronic low back pain;chronic pain;chronic painful condition;circadian;Circadian Dysregulation;Circadian Rhythms;Clinical;coping;Depressed mood;Development;diaries;disability;Disabling condition;Dose;effective intervention;Electroencephalography;Evaluation;Evolution;Exhibits;Fibromyalgia;follow-up;Genes;Genetic Polymorphism;Health Care Costs;High Prevalence;Home;Hour;improved;Incidence;indexing;Individual;insight;Intervention;Knowledge;Laboratory Study;Lead;Link;Measures;member;Mental Depression;Migraine;modifiable risk;monitoring device;multimodality;Nociceptive Stimulus;novel;Orofacial Pain;Pain;Pain Disorder;pain inhibition;Pain Research;pain-related disability;Participant;Pathway interactions;Patient Self-Report;perceived stress;Phase;Polysomnography;Population;prevent;Prevention approach;Prevention strategy;prospective;Proxy;psychological distress;recruit;response;Risk;Risk Assessment;Risk Factors;Role;Seminal;Sensory;Severities;shift work;Site;Sleep;Sleep Deprivation;Sleep disturbances;Sleep Fragmentations;sleep pattern;statistics;Temporomandibular Joint Disorders;Testing;Time;treatment strategy;urinary;Visit;wireless;Work;Wrist

PROJECT_TITLE: Sleep and circadian rhythm disturbances as risk and progression factors for multiple chronic pain conditions

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cardiovascular;Clinical Research;Congenital Heart Disease;Congenital Structural Anomalies;Heart Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Rare Diseases

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: Project Narrative: This project will develop new data-driven and machine learning methods for accurate and reproducible analysis of diffusion MRI scans of fetuses in utero, and will extensively validate these new methods and compare them with existing techniques. The final methods will be critically assessed by using them to quantify the impact of congenital heart disease on the development of fetal brain micro-structure. More broadly, the technologies developed in this project will enable assessment of fetal brain development and degeneration with unprecedented detail and reproducibility.

PI_NAMEs: KARIMI, DAVOOD  (contact)

PROGRAM_OFFICER_NAME: UTZ, URSULA

PROJECT_TERMS: Address;analysis pipeline;Anatomy;Anisotropy;Awareness;Biological Markers;biophysical model;Brain;brain abnormalities;brain based;Calibration;Compensation;computerized data processing;Congenital Abnormality;congenital heart abnormality;Consumption;convolutional neural network;Corpus Callosum;Corticospinal Tracts;Data;Data Analyses;deep learning;density;Development;Diffusion;Diffusion Magnetic Resonance Imaging;Disease;Estimation Techniques;experimental study;fetal;Fetal Development;Fetal Structures;Fetus;Fiber;Generations;Gestational Age;Goals;Histologic;Human;Image;improved;in utero;Inferior;Knowledge;Label;Learning;Machine Learning;machine learning method;Manuals;Maps;mathematical model;Measurement;Measures;Methodology;Methods;Morphologic artifacts;Motion;MRI Scans;Neonatal;network architecture;neural network architecture;Neurites;Neurodevelopmental Disorder;Noise;novel;Pathway interactions;Population Study;postnatal;Pregnancy;Premature Infant;Process;Reproducibility;Research;Resolution;Scanning;Shapes;Signal Transduction;spatiotemporal;Structure;Techniques;Technology;Testing;Time;tool;Training;training data;Training Technics;Uncertainty;white matter;Work

PROJECT_TITLE: Enabling the Assessment of Fetal Brain Development and Degeneration with Machine Learning

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Mental Health;Mental Illness;Neurodegenerative;Neurosciences;Psychosis;Schizophrenia;Serious Mental Illness

ORG_CITY: MANHASSET

ORG_NAME: FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH

ORG_STATE: NY

PHR: Project Narrative This project aims to examine in vivo tau pathology in specific structural and functional connectivity networks as mediator of psychotic symptoms in Alzheimer’s disease, which are associated with a faster cognitive and functional decline and increased mortality.

PI_NAMEs: GOMAR, JESUS J (contact)

PROJECT_TERMS: Address;Alzheimer's Disease;Alzheimer's disease patient;Amyloid;Area;Atrophic;Autopsy;Behavioral;Brain;burden of illness;career;career development;Caregiver Burden;Cerebrospinal Fluid;Cerebrum;Clinical;Cognitive;Cognitive deficits;Data;Delusions;Development;Diffusion Magnetic Resonance Imaging;Economics;effective therapy;Executive Dysfunction;executive function;experience;frontal lobe;functional decline;Functional Magnetic Resonance Imaging;Future;Generations;global health;Goals;gray matter;Hallucinations;imaging approach;imaging properties;Impaired cognition;Impairment;improved;in vivo;Inferior;innovation;insight;Investigation;K-Series Research Career Programs;Lateral;Link;Measures;Mediator;Methods;molecular imaging;mortality;Multimodal Imaging;multimodal neuroimaging;network dysfunction;Neurobiology;neuroimaging;Neuropsychology;Occipital lobe;Parietal;Parietal Lobe;Pathology;Patients;phenomenological models;Positron-Emission Tomography;Psychologist;Psychoses;psychotic symptoms;Public Health;radiotracer;Research;Research Activity;Rest;Role;Schizophrenia;Short-Term Memory;skills;social;social cognition;Specificity;tau aggregation;tau Proteins;Techniques;Temporal Lobe;Testing;Tracer;tractography;Training;Training Activity;white matter

PROJECT_TITLE: Tau networks in AD psychosis

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development For Early Career Investigators Study Section [AGCD-2]


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Cancer;Dementia;Gene Therapy;Genetics;Immunotherapy;Infectious Diseases;Neurodegenerative

ORG_CITY: STANFORD

ORG_DEPT: CHEMISTRY

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative: This project involves interconnected synthetic, mechanistic, structural, computer modeling, biochemical mode of action, preclinical, and extensive collaborative studies directed at bryostatin 1, a PKC modulator entered into clinical trials for HIV/AIDS eradication and for treating Alzheimer's disease and proposed as a clinical candidate for enhancing immuno-therapy for cancer, suppressing T cell exhaustion and treating multiple sclerosis. This project is directed at understanding how the structures of bryostatin and other natural as well as designed PKC modulators influence their PKC binding, translocation selectivity, clinically relevant biological activity and tolerability and the use of this knowledge to design, synthesize and evaluate potentially superior, better tolerated, disease specific and more synthetically accessible candidates for clinical use.

PI_NAMEs: WENDER, PAUL ANTHONY (contact)

PROGRAM_OFFICER_NAME: FU, YALI

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Acute Lymphocytic Leukemia;Address;Affinity;Alzheimer's Disease;Anabolism;analog;Animals;anti-cancer research;Antibodies;Antigen Targeting;Antigens;antiretroviral therapy;Aquaculture;Area;Award;Binding;Biochemical;Biological;Biological Assay;bryostatin;cancer clinical trial;cancer immunotherapy;cancer therapy;Canis familiaris;CAR T cell therapy;career;CD22 gene;Cell Physiology;Cell Therapy;Cells;Cellular Assay;Child;chimeric antigen receptor T cells;Chronic;Clinical;clinical candidate;Clinical Research;Clinical Trials;clinically relevant;clinically significant;Clustered Regularly Interspaced Short Palindromic Repeats;comparative;Computer Models;Cooperative Research and Development Agreement;cost;COVID-19 vaccine;Cyclic AMP-Dependent Protein Kinases;density;design;Development;Disease;Disseminated Malignant Neoplasm;DNA;Drug Delivery Systems;Epigenetic Process;Evaluation;exhaustion;Family;FDA approved;Foundations;Genomics;Goals;Grant;guanidinium;Health;HIV;HIV Seropositivity;HIV/AIDS;Human;humanized mouse;immune clearance;Immune system;Immunology;Immunotoxins;In Vitro;Individual;Injections;Knowledge;Lead;Letters;Licensing;Malignant Neoplasms;marine;Mast Cell Neoplasm;Medicine;Messenger RNA;Modification;molecular transporter;mouse model;mRNA delivery;Multiple Sclerosis;Mus;natural product inspired;Natural Products;Neurology;NK cell therapy;novel;novel therapeutics;pandemic disease;Patients;Penetration;Peptides;Pharmaceutical Preparations;phase II trial;pre-clinical;preclinical study;Prodrugs;Productivity;programs;Protein Engineering;Protein Isoforms;Protein Kinase C;Proviruses;Publications;Reporting;Research;Resistance;Role;scaffold;scale up;Scientist;Seminal;Small Interfering RNA;small molecule;solid state nuclear magnetic resonance;Source;Structure;T-Lymphocyte;Technology;Therapeutic;Time;Toxic effect;Trees;United States National Institutes of Health;virology;Virus;Work

PROJECT_TITLE: Synthetic Studies Related to Cancer Research/Treatment

STUDY_SECTION: SBCA

STUDY_SECTION_NAME: Synthetic and Biological Chemistry A Study Section[SBCA]


PHR: Project Narrative Respiratory syncytial virus (RSV) lower respiratory infection remains one of the most consistently identified risk factors for developing childhood asthma; approximately 50% of all infants are infected with RSV in their first year of life, placing them at potential risk for subsequent childhood asthma. In this application, Project 1 aims to understand the age-dependent effects of RSV infection, its role in airway epithelial developmental and epigenetic programming and assessing gene x RSV interactions as a genetic approach to determine if a child's genetic risk for asthma depends on whether or not they were infected with RSV in early life. Project 2 similarly focuses on the host, using a clinical trial design in mice to determine the mechanisms through which citrulline decreases type 2 immune responses and how it may modify the response to RSV infection.

PI_NAMEs: HARTERT, TINA V (contact);PEEBLES, RAY STOKES

PROGRAM_OFFICER_NAME: SUBRAMANIAN, HARIHARAN

PROJECT_TERMS: Acute;Address;Age;age related;airway epithelium;Asthma;asthma prevention;Biological Process;Birth;Blood;Bronchiolitis;Cells;Cellular Metabolic Process;chemokine;Child;Childhood;Childhood Asthma;chronic respiratory disease;Citrulline;Clinical;Clinical Trials Design;cohort;complex data;Confidence Intervals;cytokine;Data;Data Analyses;data management;Data Set;design;Development;Developmental Process;Diet;dietary;Dietary Supplementation;Disease;DNA Methylation;Epigenetic Process;epigenetic regulation;Epithelial Cells;Event;experience;Frequencies;Funding;Generations;Genes;Genetic;genetic approach;Genetic Risk;Human;Hypersensitivity;Immune;Immune response;immunopathology;In Vitro;in vitro Model;Individual;individual variation;infancy;Infant;infant infection;Infection;Interleukin-13;Laboratories;Life;Lower Respiratory Tract Infection;Lung;Mediating;Membrane;Metabolic;Metabolic dysfunction;Metabolism;Mus;Nose;Odds Ratio;offspring;Parents;Predisposition;Pregnancy;prenatal;prevent;Prevention strategy;Production;programs;Proliferating;protective effect;Randomized;Recurrence;Resources;respiratory health;respiratory microbiome;Respiratory syncytial virus;Respiratory Syncytial Virus Infections;response;restraint;Risk;Risk Factors;Role;Services;Source;study population;Supplementation;Testing;therapeutic target;Time;Variant;Viral;Viral Genes;Virus Diseases;Vitamins;Watermelon;Wheezing

PROJECT_TITLE: Viral and Host Determinants of Infant and Childhood Allergy and Asthma


NIH_SPENDING_CATS: Asthma;Lung;Pediatric

PI_NAMEs: PEEBLES, RAY STOKES (contact)

PROJECT_TERMS: Advisory Committees;Area;Asthma;Budgets;Childhood;Communication;Complex;Computer Hardware;Computer software;Consensus;cost;cost efficient;Cost Savings;data management;Databases;Discipline;Equipment and Supplies;Funding;Goals;Grant;Human Resources;Hypersensitivity;Infant;Leadership;Maintenance;meetings;Mission;Monitor;operation;Productivity;programs;Progress Reports;Records;Research Personnel;Resources;Schedule;Services;Structure;symposium;United States National Institutes of Health;Universities;Viral;Vision;Work

PROJECT_TITLE: Administrative Core


PI_NAMEs: HARTERT, TINA V (contact)

PROJECT_TERMS: 10 year old;8 year old;acronyms;Address;Age;airway epithelium;Allergic Disease;Asthma;Biometry;Birth;Blood;Child;Childhood;Childhood Asthma;Clinic;Clinical;Clinical Management;clinical phenotype;Clinical Research;cohort;Collection;Core Assembly;Data;data acquisition;Data Analyses;Data Collection;data management;design;Development;Discipline of obstetrics;Disease Outcome;DNA;Enrollment;Ensure;Environment;Epidemiologist;epidemiology study;Epithelial Cells;experience;follow-up;Funding;Human;human population study;Hypersensitivity;Immune;Immunologist;infancy;Infant;Infection;Infrastructure;Intervention;Laboratories;Lung infections;Methodology;multidimensional data;Neonatal;Nose;novel;Pathway interactions;Peripheral Blood Mononuclear Cell;Persons;Phenotype;Physiological;Predisposition;Pregnancy;Process;Randomized;recruit;Research;Research Personnel;Resources;respiratory morbidity;Respiratory syncytial virus;Respiratory Syncytial Virus Infections;Role;Sampling;Site;Specimen;Structure;study population;synergism;Techniques;Testing;United States National Institutes of Health;Viral;Virus;Visit;Woman

PROJECT_TITLE: Clinical Ascertainment, Biospecimen Acquisition, Data Management and Analysis Research Core


NIH_SPENDING_CATS: Cardiovascular

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: The underlying cellular and molecular mechanisms that lead to the development of thoracic aortic aneurysm and dissection (TAAD) remain not fully elucidated. Studies in this proposal aim to characterize the importance of endothelial CCN3 in the maintenance of vascular health and its role against the progression of TAAD. Results gleaned from our studies may facilitate the development of novel therapies to ameliorate TAAD progression.

PI_NAMEs: LIN, ZHIYONG  (contact)

PROGRAM_OFFICER_NAME: GALIS, ZORINA S

PROJECT_TERMS: Address;Angiotensin II;Animals;Anti-Inflammatory Agents;Aorta;Aortic Aneurysm;Atlases;Automobile Driving;Behavior;Biochemical;Blood Vessels;Cell Communication;cell type;Cells;Communication;conditional knockout;Development;Dilatation - action;Dissection;Endothelial Cells;endothelial dysfunction;Endothelium;Environmental Risk Factor;Event;Exhibits;experimental study;Exposure to;Extracellular Matrix Degradation;Foundations;Functional disorder;Gene Family;gene network;Glean;Health;Histologic;Homeostasis;In Vitro;in vivo;Incidence;Inflammasome;Inflammation;Infusion procedures;inhibitor;insight;Knockout Mice;Knowledge;Laboratories;Left;Leucocytic infiltrate;Maintenance;Marfan Syndrome;Medical;member;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;Mutation;novel;novel therapeutic intervention;novel therapeutics;Operative Surgical Procedures;Organ;Oxidative Stress;Pathogenesis;Pathologic;pharmacologic;Physiological;Physiology;Play;prevent;Prevention;Property;Proteins;Reactive Oxygen Species;Regulation;Research;Role;Rupture;Secondary to;Severities;Signal Pathway;single-cell RNA sequencing;Therapeutic;Thoracic aorta;Thoracic Aortic Aneurysm;Tissues;transcriptome sequencing;Vascular Diseases;Vascular Endothelium;vascular inflammation;Work

PROJECT_TITLE: Matricellular protein CCN3 in vascular homeostasis

STUDY_SECTION: AVI

STUDY_SECTION_NAME: Atherosclerosis and Vascular Inflammation Study Section[AVI]


PI_NAMEs: GEBRETSADIK, TEBEB  (contact)

PROJECT_TERMS: 10 year old;acronyms;Address;airway epithelium;Animals;Asthma;Bioinformatics;Biological Assay;Biometry;Birth;Blood;Cellular Metabolic Process;Childhood;Clinical;Clinical Data;cohort;Collaborations;Collection;Complex;complex data;Core Assembly;Data;Data Analyses;Data Collection;data management;data quality;Data Set;Data Sources;Database Management Systems;Development;DNA Methylation;Ensure;Environment;Epigenetic Process;Epithelial Cells;experience;Funding;Genetic;genetic analysis;genome wide association study;Human;human population study;Hypersensitivity;Immune;Immunologics;Infant;Infection;Infrastructure;Intervention;Laboratories;Lung infections;Methodology;microbiome;Neonatal;Nose;novel;Organizational Efficiency;Pathway interactions;Performance;Peripheral Blood Mononuclear Cell;Phenotype;Physiological;Predisposition;Protocols documentation;Quality Control;Reproducibility;Research;Resources;respiratory morbidity;Respiratory syncytial virus;Role;Sampling;Site;skills;success;synergism;System;Testing;transcriptome sequencing;United States National Institutes of Health;Viral;Virus;Work

PROJECT_TITLE: DATA MANAGEMENT AND ANALYSIS RESEARCH CORE


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cardiovascular;Heart Disease;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Transplantation

ORG_CITY: HOUSTON

ORG_NAME: TEXAS HEART INSTITUTE

ORG_STATE: TX

PHR: PROJECT NARRATIVE End-stage heart failure is one of the leading causes of death and disability in the US, and options for these patients, including heart transplantation, are minimal. Researchers are trying to build transplantable hearts from human stem cells and organ scaffolds, but the immaturity of the lab-grown heart muscle cells is a significant obstacle. We will develop an innovative womb-like machine that provides the mechanical, electrical, and biological signals to develop bioartificial ventricles, establishing the platform for a potential new wave of breakthroughs in cardiac tissue engineering toward building a bioartificial heart.

PI_NAMEs: HOCHMAN-MENDEZ, CAMILA  (contact)

PROGRAM_OFFICER_NAME: THAKAR, RAHUL GAUTAM

PROJECT_TERMS: 3-Dimensional;3D Print;Address;Anatomy;Automobile Driving;Bioartificial Organs;Biochemical;Biological;Biomedical Engineering;Biophysics;Bioreactors;Cardiac Myocytes;cardiac tissue engineering;Cardiovascular system;Cause of Death;Cell Maturation;Cell Physiology;Cells;Cessation of life;Clinical;Coupled;Data;deprivation;design;Development;Dilated Cardiomyopathy;disability;disease model;EFRAC;Electric Stimulation;Endothelial Cells;Engineering;experience;Extracellular Matrix;fatty acid metabolism;fatty acid supplementation;Fatty Acids;Feedback;Fostering;Functional disorder;Generations;Glucose;Goals;Grant;Heart;heart dimension/size;Heart failure;Heart Rate;Heart Transplantation;Heart Ventricle;Human;human induced pluripotent stem cells;human stem cells;Hypoxia;Impairment;improved;in vivo;Incubated;induced pluripotent stem cell;induced pluripotent stem cell derived cardiomyocytes;innovation;Left ventricular structure;Liquid substance;Measures;mechanical drive;Mechanical Stimulation;Mechanics;Metabolic;metabolic profile;Methods;mimetics;Neonatal;novel;novel strategies;Organ;Organ Donor;Oryctolagus cuniculus;Oxygen;oxygen transport;Pathologic;Patients;Performance;Physiological;Protocols documentation;prototype;Public Health;Rattus;Regenerative Medicine;Regimen;Regulation;Reporting;Research;Research Personnel;response;restoration;Risk;scaffold;scale up;Shapes;Signal Transduction;Stimulus;Stress;Structure;Supplementation;Surface;System;technological innovation;Technology;Thick;Tissue Engineering;Tissues;Training;Transplantation;Uterus

PROJECT_TITLE: Coordinated Heart Stimulation Testbed: A Platform for Contractile Ventricle Engineering

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]


PROJECT_TERMS: Acute;Age;age related;airway epithelium;Anti-viral Response;Asthma;asthma prevention;Biological;Biological Process;Birth;Candidate Disease Gene;Cell Differentiation process;Cellular Metabolic Process;Characteristics;Child;Childhood;Childhood Asthma;chronic respiratory disease;complex data;Data;Data Set;design;Development;Developmental Process;Disease;Disease Pathway;DNA Methylation;early childhood;Epithelial Cells;Epithelium;Etiology;experimental study;Funding;Genes;Genetic Predisposition to Disease;Genetic Risk;Genetic study;genomic locus;Human;Hypersensitivity;Immune response;In Vitro;in vitro Model;Individual;individual variation;infancy;Infant;infant infection;Infection;Laboratories;Life;Lower Respiratory Tract Infection;Mediation;Mediator;Metabolic;Metabolism;metabolomics;Modeling;Morbidity - disease rate;mouse model;nasal microbiome;Nose;novel;Outcome;Pathway interactions;Phenotype;Play;Predisposition;Prevention;Process;programs;Publishing;Randomized;Recurrence;respiratory health;Respiratory syncytial virus;Respiratory Syncytial Virus Infections;response;Risk;Role;Series;sex;Sex Differences;Testing;Time;transcriptomics;Variant;Viral;Wheezing

PROJECT_TITLE: RSV and asthma: Defining host and exposure variation on disease development


NIH_SPENDING_CATS: Biotechnology;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Genetics;Human Genome;Liver Disease;Prevention;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Nonalcoholic fatty liver disease (NAFLD) is a common and potentially very serious disorder that can lead to cirrhosis and liver cancer. A person’s genetic background represents an important risk factor for NAFLD and the risk involves the combined effect of many genes. The goal of this research project is to use stem cells previously generated from NAFLD patients to understand how multiple genetic risk factors combine to cause NAFLD. This information will help us tailor NAFLD treatments to individual patients based on their genetic profile.

PI_NAMEs: MAHER, JACQUELYN J. (contact);MATTIS, ARAS NIKODEMAS;WILLENBRING, HOLGER

PROGRAM_OFFICER_NAME: PAWLIKOWSKA, LUDMILA SYLWIA

PROJECT_TERMS: Address;Affect;biobank;Biological;Biological Assay;Biological Models;Cataloging;Catalogs;Cell Culture Techniques;Cell Differentiation process;Cell Line;Cell Lineage;cell type;Cells;Cirrhosis;Clinic;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;Coculture Techniques;cohort;Collection;combinatorial;Communities;comparative;CRISPR interference;CRISPR screen;Data;data library;Data Set;defined contribution;Development;Disease;disease model;Disease Outcome;disease phenotype;Ensure;Environmental Risk Factor;Evaluation;Exhibits;experimental study;fibrogenesis;Fibrosis;Foundations;Future;gene correction;Gene Expression Profile;Genes;Genetic;Genetic Predisposition to Disease;genetic risk factor;genetic variant;genome wide association study;genome-wide;Goals;Health Care Costs;Hepatic Stellate Cell;Hepatocyte;Hepatology;Human;Image;Impairment;In Vitro;Individual;individual patient;induced pluripotent stem cell;Inflammation;Inflammatory;Information Dissemination;Insulin Resistance;knock-down;Libraries;Lipids;Liver;Liver diseases;Macrophage;Malignant neoplasm of liver;Measures;Mediating;Metabolic;miniaturize;Mitochondria;Modeling;Morphology;Multiomic Data;non-alcoholic fatty liver disease;novel;Obesity;Outcome;Parents;Pathogenesis;patient derived induced pluripotent stem cells;Patients;Persons;Pharmaceutical Preparations;Phenotype;population based;Process;protective allele;Proteomics;Publishing;Reporter;Research;Research Project Grants;Resources;Risk;Risk Factors;risk variant;RNA Interference;screening;Services;Stains;Standardization;stem cell model;stem cells;System;targeted treatment;Testing;theories;Therapeutic Intervention;transcriptomics;Translations;Validation;Variant;web platform;whole genome

PROJECT_TITLE: Establishing patient-derived iPSCs as a platform for discovery research in NAFLD


NIH_SPENDING_CATS: Biotechnology;Cancer;Lung;Lung Cancer;Orphan Drug;Prevention;Rare Diseases

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: PROJECT NARRATIVE This Coordinating Center promotes information exchange, resource sharing, and collaboration among investigators in the NCI-supported Small Cell Lung Cancer Consortium, with the ultimate goal of reducing the impact of this disease by facilitating clinical translation toward prevention, early detection, and novel therapeutic research.

PI_NAMEs: BYERS, LAUREN AVERETT;MINNA, JOHN D.;OLIVER, TRUDY GALE;RUDIN, CHARLES M. (contact)

PROGRAM_OFFICER_NAME: UJHAZY, PETER

PROJECT_TERMS: Address;Administrative Coordination;Advocate;anti-cancer research;Area;Award;Bioinformatics;Biological;Biological Specimen database;Biometry;cancer immunotherapy;Cancer Model;Cataloging;central database;Clinical;clinical translation;Clinical Trials;cohort;Collaborations;Collection;Communication;Communities;comparative;Congresses;Data;Data Analyses;Data Analytics;Databases;design;Development;Disease;disease model;disorder prevention;Early Diagnosis;Early Intervention;Epigenetic Process;Fostering;Funding;Funding Opportunities;Generations;Genetic Databases;Genetically Engineered Mouse;Goals;Grant;Growth;Health;Human;Immunologic Surveillance;Immunologics;improved;in vitro Model;in vivo;Individual;innovation;insight;Institution;Intervention;Knowledge;Leadership;Maintenance;Malignant Neoplasms;meetings;member;Metastasis Suppression;Modeling;Molecular and Cellular Biology;Mus;novel strategies;novel therapeutics;Oncogenic;Pathology;patient derived xenograft model;Patient-Focused Outcomes;Patients;Peer Review;pre-clinical;Prevention;Prevention strategy;Principal Investigator;Proteomics;Publications;repository;Research;Research Personnel;Resource Sharing;Resources;Role;Rotation;Secure;small cell lung carcinoma;Societies;Structure;success;Sum;synergism;Teleconferences;Therapeutic;Therapeutic Research;tissue resource;transcriptomics;Translational trial;tumor;Universities;University of Texas M D Anderson Cancer Center;Utah;virtual;web site;Work

PROJECT_TITLE: Coordinating center for the NCI small cell lung cancer research consortium


ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

PROJECT_TERMS: Affect;airway epithelium;airway obstruction;Allergic Disease;antiviral immunity;Asthma;Birth;Blood;Breeding;Bronchiolitis;Cell Physiology;Cells;chemokine;Child;Childhood;Childhood Asthma;Citrulline;clinically significant;cohort;Cohort Studies;Confidence Intervals;cost;cytokine;Cytokine Gene;Data;Development;Diagnosis;Diet;dietary;Dietary Supplementation;Disease;Enrollment;epigenetic regulation;Epithelial Cells;Female;Frequencies;Funding;Gene Expression;Generations;Hospitalization;Human;Hypersensitivity;Immune response;immunopathology;in vivo;infancy;Infant;Infection;innovation;Interleukin-13;Life;Link;Lung;Lung infections;male;Membrane;Mus;Neonatal Screening;Nose;Odds Ratio;offspring;Parents;population based;Predisposition;Pregnancy;Pregnant Women;prenatal;prevent;Production;Proliferating;protective effect;protein expression;Publishing;Records;recruit;Research;Respiratory Syncytial Virus Infections;response;restraint;Risk;Risk Factors;Role;sex;Source;study population;Supplementation;Tennessee;Testing;Time;United States;Viral;Viral Respiratory Tract Infection;Vitamins;Watermelon;Weaning;Wheezing

PROJECT_TITLE: RSV-induced type 2 immune responses are inhibited by dietary citrulline supplementation during gestation and early life


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Contraception/Reproduction;Genetics

ORG_CITY: ITHACA

ORG_DEPT: ZOOLOGY

ORG_NAME: CORNELL UNIVERSITY

PHR: Project Narrative Reproduction and immune defense are both physiologically demanding processes, and each constrains the other in humans and in a wide variety of animal systems. The proposed study will determine the mechanistic basis and evolutionary consequences of reproduction-immunity tradeoffs in the genetic model insect, Drosophila melanogaster, specifically testing the hypothesis that such tradeoffs can be hormonally regulated. The conclusions from this work will be broadly applicable across human and animal systems, especially including insects with agricultural and public health importance.

PI_NAMEs: LAZZARO, BRIAN  (contact)

PROGRAM_OFFICER_NAME: SINGLETON, KENTNER L

PROJECT_TITLE: Mechanisms and Evolutionary Consequences of a Reproduction-Immunity Tradeoff

STUDY_SECTION: GVE

STUDY_SECTION_NAME: Genetic Variation and Evolution Study Section[GVE]


NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Biomedical Imaging;Brain Cancer;Brain Disorders;Cancer;Hydrocephalus;Neurosciences;Rare Diseases

ORG_DEPT: ENGINEERING (ALL TYPES)

PHR: Project Narrative Brain tumors are usually associated with elevated intracranial pressure (ICP) and continuous ICP measurements are essential to prevent irreversible neurological damages in these patients. This research proposes to develop highly sensitive, ultrasmall and brain compatible bioelectronic sensors, that are designed for long-term and wireless ICP measurements. We envision that this clinically-needed flexible bioelectronic technology can have utility with several other types of brain diseases that are highly correlated with elevated ICP, such as hydrocephalus and stroke.

PI_NAMEs: KHALIFEHZADEH, LAYLA  (contact)

PROGRAM_OFFICER_NAME: FALCONE, JESSICA

PROJECT_TERMS: Award;Basic Cancer Research;Biocompatible Materials;bioelectronics;biomaterial compatibility;Biomedical Engineering;Brain;Brain Diseases;brain magnetic resonance imaging;Brain Neoplasms;brain tissue;Butadiene;cancer diagnosis;cancer imaging;Cancer Patient;cancer therapy;Cardiovascular system;career;career development;Cellular Phone;Cerebrospinal Fluid;Cessation of life;Clinical;clinical application;cost;Data;design;Detection;Devices;Diagnosis;diagnostic technologies;Disease;Doctor of Philosophy;elastomeric;Elastomers;Electric Capacitance;Elements;Emergency Situation;Engineering;Environment;experience;experimental study;fabrication;flexibility;Frequencies;Future;Geometry;Goals;Growth;Heart-Assist Devices;Histology;Hospitals;Hydrocephalus;Immune response;Immunohistochemistry;Implant;implantable device;implantation;improved;in vivo;Incubated;Individual;Intervention;Intracranial Hypertension;Intracranial Pressure;Kinetics;Left;Life;light weight;Link;Magnetic Resonance Imaging;Malignant neoplasm of brain;Malignant Neoplasms;Measurement;Measures;Medicine;Mentors;meter;model design;Monitor;Morphology;mouse model;multidisciplinary;Mus;Nanotechnology;neglect;Nervous System Trauma;neural implant;Neurologic;Neurology;neurosurgery;Noise;Operative Surgical Procedures;optical imaging;parylene;Patients;Pattern;Performance;point of care;Polymers;pressure;pressure sensor;prevent;Procedures;Program Development;programs;Research;research and development;Research Personnel;response;Rights;Schools;Scientist;sensor;Signal Transduction;simulation;Stents;Stroke;Structure;Styrenes;System;Technology;temporal measurement;Testing;Therapeutic;Thick;Thinness;Time;Training;tumor;Tumor Cell Line;tumor growth;Tumor Volume;Urinary system;Variant;water diffusion;wearable device;wireless;wireless communication;wireless sensor

PROJECT_TITLE: Flexible and Wireless Bioelectronics for Continuous Monitoring of Intracranial Pressure

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Clinical Research;Contraception/Reproduction;Women's Health Research

ORG_CITY: DURHAM

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: DUKE UNIVERSITY

PHR: PROJECT NARRATIVE Conditions affecting women's reproductive health have a significant impact on quality-of-life, overall health, and life expectancy for both women and their children. Reducing this impact through improved prevention and treatment requires researchers with a fundamental understanding of the clinical impact of these conditions and the ability to apply rigorous, innovative methods to facilitate discovery and translation into effective interventions. The Duke Women's Reproductive Health Research training program combines cutting-edge research experiences with an innovative and proven career development framework to help develop the next generation of obstetrician-gynecologist clinician-scientists.

PI_NAMEs: BARBER, MATTHEW D (contact)

PROGRAM_OFFICER_NAME: KAUFMAN, STEVEN

PROJECT_TERMS: Advisory Committees;Area;career;career development;clinical practice;cohort;Communicable Diseases;Conceptions;Dedications;Development Plans;Educational workshop;Environment;Evaluation;experience;Feedback;Fostering;Funding;Generations;Goals;Group Meetings;Gynecologist;hands on research;Human Development;Immunology;Infrastructure;innovation;Institution;Interdisciplinary Study;Journals;Lead;Leadership;Malignant Female Reproductive System Neoplasm;Mentored Clinical Scientist Development Program;Mentors;Methods;Monitor;multidisciplinary;next generation;novel;peer;Peer Review;Pelvic Floor Disorders;Perinatology;Pregnancy;Program Development;programs;Publishing;recruit;reproductive;Research;Research Methodology;Research Personnel;Research Project Grants;Research Training;Resource Development;Resources;responsible research conduct;Science;skills;Testing;Time;tool;Training;Vocational Guidance;women's reproductive health;Work

PROJECT_TITLE: Duke Women's Reproductive Health Research Scholars


ORG_CITY: MEMPHIS

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

PHR: PROJECT NARRATIVE Genome editing technologies have potential to become safe new genomic medicines to address fundamental genetic causes of human disease. Although fit-for-purpose cellular methods like GUIDE-seq to define the safety and genome-wide off-target activity of human genome editing products are essential during both pre-clinical and IND enabling phases of development, fully optimized and qualified protocols for use in regulatory submissions are not generally available. Here we propose to optimize and qualify GUIDE-seq-2, an improved, highly scalable, and accurate version of GUIDE-seq we recently developed, for use in future therapeutic genome editing IND submissions.

PI_NAMEs: TSAI, SHENGDAR  (contact)

PROGRAM_OFFICER_NAME: POON, BETTY

PROJECT_TERMS: Address;Adopted;Adoption;Affect;Biological Assay;cancer immunotherapy;cell type;Cellular Assay;Chemistry;Collaborations;Computer software;Data;Development;DNA Double Strand Break;DNA Integration;Future;Gene Transduction Agent;Genetic;Genetic Variation;genome editing;genome editor;genome-wide;Genome-wide Unbiased Identification of DSBs Enabled by sequencing;Genomic DNA;Genomic medicine;Goals;Hepatocyte;High-Throughput Nucleotide Sequencing;Human Activities;human disease;Human Genome;improved;in vivo;Individual;Informatics;Investigational Drugs;Investigational New Drug Application;Lead;lead candidate;leukemia;manufacture;member;Methods;Neurons;novel;nuclease;off-target mutation;Outcome;patient safety;Patients;Performance;Pharmaceutical Preparations;Phase;pre-clinical;preclinical development;prime editor;product development;Proto-Oncogenes;Protocols documentation;Qualifying;Reproducibility of Results;Safety;Sickle Cell Anemia;Site;somatic cell gene editing;Specificity;T-Lymphocyte;Technology;Testing;Therapeutic;therapeutic evaluation;therapeutic genome editing;Translations;Viral Vector

PROJECT_TITLE: Sensitive, unbiased, high-throughput, cellular GUIDE-seq-2 genome-wide activity assay for therapeutic genome editing INDs

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MGG-M(70)R]


ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: NARRATIVE Broadly neutralizing antibodies (bnAbs) against HIV-1 provide new opportunities for immunotherapy and prevention but the development of HIV-1 resistance to bnAbs is still an obstacle for medical interventions. Here we will study how HIV-1 strains resist multiple bnAbs and investigate indirect pathways that HIV-1 may use to escape bnAbs. We will define new ways to overcome HIV-1 resistance to bnAbs and provide important insights into the interactions of HIV-1 and bnAbs.

PI_NAMEs: ACHARYA, PRIYAMVADA ;CRISPIN, MAX ;DEKOSKY, BRANDON JAMES;HERSCHHORN, ALON  (contact)

PROGRAM_OFFICER_NAME: JANCI, ELIZABETH WONDERLICH

PROJECT_TERMS: Affect;Affinity;Amino Acid Sequence;Amino Acids;Antibodies;antibody immunotherapy;Antibody Therapy;Binding;Biological Assay;Biomedical Engineering;Cells;Clinical Research;Clinical Trials;Communities;cost;Data;Development;Directed Molecular Evolution;Epitopes;Evolution;Exhibits;fitness;Future;Glycoproteins;glycosylation;HIV resistance;HIV-1;Immunotherapy;improved;in vivo;insight;Intervention;Knowledge;knowledge base;Measures;Mediating;Medical;Molecular;Molecular Conformation;neutralizing antibody;Participant;Pathway interactions;Patients;Pattern;Polysaccharides;Population;Prevention;preventive intervention;Property;Public Health;Recombinants;Resistance;resistance mechanism;resistant strain;Resolution;Sampling;screening;Serum;Site;Source;Structure;Sum;synergism;Technology;Testing;Therapeutic;tool;transmission process;United States National Institutes of Health;Vaccines;Viral;Virus;Virus Replication;Work;Yeasts

PROJECT_TITLE: Dissecting the mechanisms of HIV resistance in vivo to broadly neutralizing antibodies


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Cancer;Dental, Oral, and Craniofacial Disease;Genetics;Hematology;Infectious Diseases;Lymphatic Research;Lymphoma;Rare Diseases

ORG_DEPT: DENTISTRY

PHR: PROJECT NARRATIVE As an orally transmitted pathogen, EBV infection causes infectious mononucleosis, oral hairy leukoplakia of tongue, and ~200,000 cases of various cancers, including nasopharyngeal carcinoma that occurs in a space immediately adjacent to the oral cavity, some B cell malignancies, and ~10% of gastric cancer. This study will determine the functions of EBV-encoded nuclear antigen leader protein (EBNALP) in transcription regulation and may lead to identification of new targets for intervening EBV-associated diseases.

PI_NAMEs: WANG, CHONG  (contact)

PROGRAM_OFFICER_NAME: MCNEALY, TAMARA L

PROJECT_TERMS: Affect;AIDS-Related Lymphoma;B Cell Proliferation;B lymphoid malignancy;B-Lymphocytes;Binding Proteins;Biological Assay;Biological Models;Cell Line;Cells;Chromatin;chromatin protein;Clustered Regularly Interspaced Short Palindromic Repeats;cofactor;CRISPR interference;CRISPR screen;Data;deep sequencing;Development;Disease;DNA;DNA-Binding Proteins;EBV-associated disease;Elements;Enhancers;Enzymes;EP300 gene;Epithelial Cells;Epstein-Barr pathogenesis;Epstein-Barr Virus Infections;Epstein-Barr Virus latency;Epstein-Barr Virus Nuclear Antigens;Epstein-Barr Virus-Related Malignant Neoplasm;Gene Expression;Gene Expression Profile;Genes;Genetic Transcription;genome-wide;Growth;Hairy Leukoplakia;Health;Histones;HIV;Human;Human Herpesvirus 4;Immune;Immune system;Immunoprecipitation;In Vitro;Infectious Mononucleosis;Knock-out;Lentivirus;Libraries;Link;LMP1;lymphoblastoid cell line;Lymphoma;Lymphoproliferative Disorders;Malignant Neoplasms;malignant stomach neoplasm;Mediating;Membrane Proteins;Mentors;Molecular;Monitor;Mucous Membrane;Mutation;Nasopharynx Carcinoma;novel therapeutics;Nuclear Antigens;Oral;Oral cavity;oral cavity epithelium;pathogen;Patients;Persons;Phase;post-transplant;Primary Infection;programs;Proliferating;promoter;protein activation;protein complex;Proteins;Reporter;Research;Rest;Role;Saliva;Signal Transduction;Simian virus 40;Site;Sorting;stable cell line;Testing;Tongue;Transcription Coactivator;transcription factor;Transcriptional Regulation;Transfection;transforming virus;transmission process;vector;Viral Proteins;Work

PROJECT_TITLE: Epstein-Barr Virus nuclear antigen leader protein in transcription regulation


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Genetics;Mental Health;Pediatric;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE The project will study participants who had severe drug and other behavioral problems when they were teens. The participants are now adults in their early 30s and some have stopped having addiction and behavior problems whereas others have kept having problems or their addictions have gotten worse as they developed cocaine, methamphetamine, or opiate addictions. The study will try to understand what factors predict continuing addiction and mental health problems and also try to understand what factors predict having fewer addiction and mental health problems as participants have gotten older.

PI_NAMEs: HOPFER, CHRISTIAN J (contact);STALLINGS, MICHAEL CRAIG;WALL, TAMARA L

PROGRAM_OFFICER_NAME: VIDAL, SARAH

PROJECT_TERMS: addiction;Address;Adolescence;Adolescent;Adopted;Adult;Affect;Age;Age of Onset;Age Years;Alcohol consumption;Alcohols;American;Amphetamines;antisocial behavior;Architecture;Attenuated;Behavior;Behavioral;California;Cessation of life;Child Abuse and Neglect;Child Rearing;Cocaine;Cocaine Dependence;Cognitive;Colorado;Communities;comorbidity;comparative;Complex;Conduct Disorder;Data;Data Analyses;Data Collection;Development;Disease;early onset substance use;Education;Employment;European;Exhibits;Female;follow up assessment;follow-up;Funding;Genetic;Genetic Predisposition to Disease;Genotype;Growth;high risk;high risk behavior;high-risk adolescents;Imprisonment;Impulsivity;indexing;Individual;injection drug use;Joints;Longitudinal Studies;male;Marijuana;marijuana use;Marriage;Measures;Mediating;Mental Health;Methamphetamine dependence;Morbidity - disease rate;mortality;Neurocognitive Deficit;nicotine use;Opiate Addiction;Opioid;Participant;Personality Character;Personality Traits;Pharmaceutical Preparations;polygenic risk score;Predictive Factor;Problem behavior;protective factors;psychiatric comorbidity;psychosocial;recruit;Reporting;Request for Proposals;Research;Risk Behaviors;Risk Factors;Role;Sampling;Severities;sex;substance use;Substance Use Disorder;substance user;Symptoms;Teenagers;Tobacco;Twin Multiple Birth;Twin Studies;young adult;Youth

PROJECT_TITLE: Adult Progression of Adolescent Onset Substance Use Disorder in a High Risk Sample

STUDY_SECTION: ARM

STUDY_SECTION_NAME: Addiction Risks and Mechanisms Study Section[ARM]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: BOSTON

ORG_NAME: TUFTS UNIVERSITY BOSTON

PHR: Narrative  Alzheimer’s disease (AD) remains one of the most unmet medical challenges in our society. This project will investigate whether there is a pathologically altered efflux of CNS cell-type specific exosomes from brain in AD models and whether and how these brain-derived exosomes may possess specific antigens to trigger peripheral T cell activation in vitro and in vivo. Results from this project will unveil new mechanisms how CNS and periphery interact in AD models.

PI_NAMEs: DEGTEREV, ALEXEI ;YANG, YONGJIE  (contact)

PROGRAM_OFFICER_NAME: MARIC, MAJA

PROJECT_TERMS: adaptive immunity;Alzheimer's Disease;Alzheimer's disease antigen;Alzheimer's disease brain;Alzheimer's disease model;Animal Disease Models;Antigens;aquaporin 4;Astrocytes;Autopsy;Axon;B-Lymphocytes;Biochemical;Blood;Blood Vessels;Brain;brain parenchyma;CD8-Positive T-Lymphocytes;cell type;Cells;cerebrovascular;Cerebrovascular system;Circulation;Clonality;Data;Detection;Disease;Early Endosome;Endosomes;Engineering;exosome;extracellular;extracellular vesicles;foot;Future;Genes;Glutamate Transporter;Human;hyperphosphorylated tau;Immune;Immune response;immunogenic;In Vitro;in vivo;in vivo two-photon imaging;Infiltration;Injections;Label;Mediating;Medical;Microglia;Molecular;mouse genetics;Multivesicular Body;Mus;Mutate;myelination;Myeloid Cells;Natural Immunity;neoplastic cell;Neurodegenerative Disorders;Neurofibrillary Tangles;neuroinflammation;Neurons;novel;Pathogenesis;Pathologic;Pathway interactions;Peripheral;Play;Population;Proteins;Reporter;Role;Senile Plaques;Serum;Signal Transduction;single-cell RNA sequencing;Societies;T-Cell Activation;T-Lymphocyte;therapeutic development;tool;Travel;Vesicle;Virus

PROJECT_TITLE: CNS Exosomes-Mediated Adaptive Immunity in Alzheimer's Disease (AD)


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Data Science;Dissemination and Implementation Research;Genetic Testing;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Orphan Drug;Patient Safety;Pediatric;Prevention;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: Project Narrative Many of over 7000 rare genetic diseases are diagnosed based partially on our understanding of their clinical features or a set of diagnostic criteria that appear in combination. We will test whether a more rigorous scientific approach to these criteria based on actual patient data from over a decade of clinical evaluations of children can improve our ability to make rare disease diagnoses. From these same data, we will develop machine learning algorithms that may one day assist non-specialists in recognizing these rare diseases in their patients.

PI_NAMEs: CAMPBELL, IAN MORGAN (contact)

PROGRAM_OFFICER_NAME: SURPRIS, MARIPIERRE PAYEN

PROJECT_TERMS: Access to Information;Address;Adopted;Age;age related;Algorithms;American;Basal Cell Nevus Syndrome;Blinded;career;career development;Child;Childhood;Chronology;Clinical;clinical decision support;Clinical Decision Support Systems;clinical diagnostics;Clinical Informatics;cohort;Computational algorithm;Consensus;Data;Development Plans;Diagnosis;diagnostic criteria;Diagnostic Specificity;diagnostic strategy;Diagnostic tests;disadvantaged background;Disease;disease diagnosis;Early Diagnosis;effectiveness evaluation;Electronic Health Record;Elements;empowerment;evidence base;experience;Family;Foundations;Funding;Future;Genetic;Genetic Diseases;genetic disorder diagnosis;Genetic Predisposition to Disease;genetic testing;Goals;Health;health inequalities;Health system;Hereditary Malignant Neoplasm;Human;human centered design;Image;improved;Individual;Inequity;Informatics;Inpatients;insight;Intervention;Judgment;Knowledge;Laboratories;Lead;Machine Learning;machine learning algorithm;machine learning framework;marginalized population;Medical;Medical Genetics;member;Methodology;Molecular;molecular targeted therapies;Natural Language Processing;novel;novel diagnostics;Online Systems;Outcome;Outpatients;Participant;Patients;Performance;Phenotype;Physicians;Population Heterogeneity;Predictive Value;Process;prognostication;programs;Rare Diseases;rare genetic disorder;Recording of previous events;reproductive;Research;research clinical testing;Research Personnel;Resolution;Risk;Sampling;Scientist;Sensitivity and Specificity;skills;Specificity;statistical and machine learning;Surveys;System;targeted treatment;Test Result;Testing;Therapeutic Intervention;Time;tool;Training;United States National Institutes of Health;usability;Validation;variant of unknown significance;Work

PROJECT_TITLE: Comprehensive Pediatric Phenotyping for Evidence-Based Diagnosis in Genetic Disease

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Pediatrics Study Section[CHHD-A]


ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

PHR: Project Narrative Industry-academia (IA) partnerships are critical for bringing neurotechnologies to market for public use and benefit, but these partnerships can introduce bias into research and commercialization processes. This project addresses a gap in our current understanding of the ethical complexities of industry-academia (IA) partnerships in the neurotechnology enterprise by engaging relevant stakeholders (e.g., industry, researchers, ethicists, university officials, patients) to identify promising solutions for navigating these complexities. The project will culminate in the development and dissemination of an innovative toolkit that helps neurotechnology research stakeholders cultivate ethical and responsible IA partnerships.

PI_NAMEs: MCINTOSH, TRISTAN  (contact)

PROGRAM_OFFICER_NAME: CHURCHILL, JAMES D

PROJECT_TERMS: Academia;Address;Adopted;Adoption;Area;Behavior;Brain;Brain Diseases;BRAIN initiative;Case Study;Clinical;clinical practice;cognitive interview;Collaborations;commercialization;Conflict of Interest;Consensus;Data;data sharing;design;Development;Devices;Education;Effectiveness;Entrepreneurship;Ethical Issues;Ethicists;Ethics;Evaluation;financial incentive;Fostering;Funding;Goals;Health;health data;Implant;Individual;Industry;industry partner;innovation;innovative neurotechnologies;Interview;Marketing;Mediation;member;Mission;Monitor;neurotechnology;Online Systems;open data;outreach;Patients;Perception;Play;Policies;prevent;Privatization;Process;Recommendation;recruit;Reporting;Research;Research Contracts;Research Personnel;Resources;Risk Factors;risk mitigation;Role;Series;Shapes;stakeholder perspectives;Surveys;Technology Transfer;Translation Process;transmission process;Universities;webinar

PROJECT_TITLE: Fostering Ethical Neurotechnology Academia-Industry Partnerships: A Stakeholder Engagement and Toolkit Development Project