ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE Current data trends in the U.S. depict an adolescent mental health crisis, with elevated rates of depression and suicidality that do not correspond with elevated treatment utilization, prompting national calls for a “holistic and equitable” approach. Simultaneously, significant increases in social media use, and its rapidly diffused mental health promotion (e.g., anti-stigma awareness campaigns, symptom support) and pejorative (e.g., stigma, hate speech, cyber-bullying) content, have shown mixed effects on mental health outcomes among adolescents. To improve our understanding of the social media landscape for adolescents and further accountability of technology as it relates to population mental health, this project will: adapt our validated, culturally relevant measures of social media use and scanning and seeking of mental health promotion and pejorative content (exposure), mental health stigma, self-perception, and help-seeking (mediators), mental health status (outcome), and other individual, family, and peer factors (covariates/moderators); focus on the critical period of adolescence (ages 13-20); conduct a prospective cohort study with longitudinal data; conduct youth participatory action research to attain a culturally competent social media database for community-based analysis; and focus on Latino adolescents to leverage natural counterfactual contexts from their diverse language/cultural social media preferences and further mental health equity goals as Latino youth report the most social media use in the U.S.

PI_NAMEs: DUPONT, MELISSA JULIANA (contact)

PROGRAM_OFFICER_NAME: CORNELL, ASHLEY ROSE

PROJECT_TERMS: Accountability;Address;Adolescence;Adolescent;adolescent mental health;Age;age group;Anxiety Disorders;Archives;Asian;Attention;Awareness;Behavior;Belief;Black race;Clip;cohesion;cohort;Communities;community based participatory research;COVID-19;critical period;Cross-Sectional Studies;cultural competence;Culture Media;cyberbullying;Data;Databases;Depressed mood;design;Diffusion;Eating Disorders;Ensure;Equity;Ethnic Population;Evaluation;experience;experimental study;Exposure disparity;Exposure to;Family;Feeling hopeless;Gender;Glean;Goals;Hate;health equity;Health Status;help-seeking behavior;Heterogeneity;improved;Individual;innovation;insight;Instagram;Internet;Intervention;intervention mapping;Interview;Knowledge;Label;Language;Latino;Latino Population;Latinx;Longterm Follow-up;Measurement;Measures;media use;Mediation;Mediator;Mental Depression;Mental disorders;Mental Health;Mental health promotion;Methodology;Methods;Modeling;Mood Disorders;new technology;novel strategies;Outcome;Participant;Pathway interactions;Patient Recruitments;peer;Policies;Population;preference;Privatization;programs;Prospective cohort;Prospective, cohort study;Qualitative Methods;Race;racial population;Randomized;Recommendation;reduce symptoms;Reporting;Research;Role;Safety;Sampling;Sampling Studies;Scanning;Self Perception;Shapes;social culture;social group;social influence;social media;Social Network;social stigma;Social support;Source;Spanish;Spanish/English;Specific qualifier value;Speech;Stigmatization;Students;success;suicidal;Surgeon;Surveillance Methods;Survey Methodology;Surveys;symptom management;Symptoms;Target Populations;Technology;Testing;theories;TikTok;Time;trend;Twitter;United States;Youth

PROJECT_TITLE: Leveraging Latinx Adolescents, Photovoice, and Longitudinal Data to Disentangle the Bidirectional Effects of Social Media and Mental Health


ADMINISTERING_IC: CA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Genetics;Human Genome;Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: STONY BROOK

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PHARMACOLOGY

ORG_FIPS: US

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

ORG_STATE: NY

PHR: PROJECT NARRATIVE Diffuse gliomas are incurable brain tumors that often harbor mutations in the isocitrate dehydrogenase 1 (IDH1) gene, leading to high levels of 2-hydroxyglutarate, which interferes with epigenetic regulation. The proposed studies use oligodendrocyte progenitor cells, candidate glioma cells-of-origin, to examine the role of epigenetic alterations found in IDH1-mutant gliomas, determine whether these epigenetic alterations can drive gliomagenesis in vivo, and examine the mitotic heritability of these lesions. Understanding the epigenetic underpinnings of glioma has the potential to inform novel therapeutic interventions for this and other incurable tumors characterized by epigenome-wide reprogramming.

PI_NAMEs: RAHME, GILBERT J (contact)

PROGRAM_OFFICER_NAME: OKANO, PAUL

PROJECT_TERMS: 3-Dimensional;Advisory Committees;Affect;aggressive therapy;Automobile Driving;Award;Binding;Binding Sites;Brain Neoplasms;career;CCCTC-binding factor;CDKN2A gene;Cell division;cell type;Cells;Characteristics;Collaborations;Combined Modality Therapy;Communities;CpG Island Methylator Phenotype;Diffuse;DNA;DNA Methylation;DNA Modification Methylases;Elements;Enhancers;Enzymes;Epigenetic Process;epigenetic regulation;epigenome;Event;Functional disorder;Gene Activation;Gene Expression;Genes;Genetic;Genome;genome-wide;Glioma;Gliomagenesis;Heritability;Human;Hypermethylation;improved;In Vitro;in vivo;in vivo Model;Inherited;inhibitor;International;Isocitrate Dehydrogenase;Lesion;Malignant - descriptor;Mediating;Medical;Mentors;Metabolic;Methylation;methylation pattern;Missense Mutation;Mitotic;Modeling;Mus;mutant;Mutation;novel therapeutic intervention;oligodendrocyte progenitor;Platelet Activation;Platelet-Derived Growth Factor alpha Receptor;Primary Brain Neoplasms;programs;Proliferating;promoter;Proto-Oncogenes;Recording of previous events;Research;Role;Scientist;Shapes;Site;stem cell niche;stem cells;Structure;Synteny;Testing;tumor;tumor initiation;Tumor Suppressor Genes;Tumor Suppressor Proteins

PROJECT_TITLE: Modeling and Dissecting Epigenetic Drivers of Gliomagenesis

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Transition to Independence Study Section (I)[NCI-I]


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Genetics;Precision Medicine;Women's Health Research

ORG_CITY: INDIANAPOLIS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Project Narrative Despite improvements in clinical considerations for cancer, a considerable number of cancer subtypes continue to lack effective targeted therapies, resulting in the urgent need for the development of previously unconsidered treatment approaches and therapeutic strategies. Following the emergence of preliminary data implicating snoRNAs as key players in a significant number of cancer-related processes and signaling pathways, this project seeks to determine the functional effects of snoRNAs in vitro and in vivo, elucidate the drug response effects of snoRNAs, and provide a comprehensive data resource for exploring the biomedical significance of snoRNAs. The proposed study will shed light on future clinical considerations for the development of targeted therapies for cancer types currently lacking effective treatment options, and it is also expected that the computational methods and experimental systems established in the proposed research will be applicable to other cancer types, thereby greatly leveraging the impact of this project.

PI_NAMEs: HAN, LENG  (contact)

PROGRAM_OFFICER_NAME: WEINREICH, MICHAEL DALE

PROJECT_TERMS: Antisense Oligonucleotides;Attenuated;Biological;Biological Markers;Biological Models;Biomedical Research;Breast Cancer Cell;Breast Cancer cell line;cancer drug resistance;cancer initiation;Cancer Patient;cancer subtypes;cancer type;Cell Proliferation;Clinical;clinically relevant;clinically significant;Communities;Computing Methodologies;Data;data portal;data resource;deep learning;Development;Diagnostic;diagnostic value;differential expression;disease diagnostic;Drug resistance;drug response prediction;effective therapy;Exhibits;Fatty acid glycerol esters;FDA approved;Foundations;Future;Genetic;Genetic Transcription;genetic variant;Goals;Growth;improved;In Vitro;in vivo;Individual;individual response;insight;Invaded;large scale data;Malignant Breast Neoplasm;Malignant Neoplasms;mammary;Mammary gland;Mammary Tumorigenesis;Molecular;mouse model;Multiomic Data;novel;Outcome;Pathway interactions;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;Play;Process;Prognosis;prognostic;prognostic value;Proliferating;Quantitative Trait Loci;refractory cancer;Research;Research Personnel;response;RNA;RNA-targeting therapy;Role;Sampling;Signal Pathway;Signal Transduction;Small Nucleolar RNA;Solid Neoplasm;success;survival outcome;System;targeted cancer therapy;targeted treatment;The Cancer Genome Atlas;Therapeutic;therapeutic RNA;therapeutic target;Transcription Alteration;treatment strategy;triple-negative invasive breast carcinoma;tumor;tumorigenesis;user-friendly;Work;Xenograft procedure

PROJECT_TITLE: Systematic Characterization of Small Nucleolar RNAs in Cancer

STUDY_SECTION: CG

STUDY_SECTION_NAME: Cancer Genetics Study Section[CG]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Crohn's Disease;Digestive Diseases;Inflammatory Bowel Disease;Microbiome;Nutrition

ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: Narrative Mounting evidence indicates that microbiome, vitamin D, and the vitamin D receptor (VDR) play unique roles in the pathogenesis of digestive diseases. Our proposed studies are designed to show how VDR regulates gut microbiome and Paneth cells and to identify the host and microbiologic factors responsible for modulating intestinal functions in chronic inflammation. Our long-term goals are to apply this information to develop novel approaches that prevent and treat dysbiosis- or VDR- associated diseases, including inflammatory bowel diseases.

PI_NAMEs: SUN, JUN  (contact)

PROGRAM_OFFICER_NAME: SENGER, STEFANIA

PROJECT_TERMS: alertness;Animal Model;anti-microbial peptide;Area;Bacterial Infections;base;bile acid metabolism;Biochemical;bioinformatics tool;Biological Factors;Biology;Biopsy;Carbohydrates;Categories;Chronic;Chronic Disease;Clinical;Colitis;Colon;Complex;conditional knockout;Crohn's disease;Data;design;Development;Digestive System Disorders;Disease;Down-Regulation;dysbiosis;Elements;Ensure;Environmental Risk Factor;Epithelial Cells;Epithelium;Etiology;fecal transplantation;Functional disorder;Gastroenterology;Genetic Predisposition to Disease;Germ-Free;Goals;gut inflammation;gut microbes;gut microbiome;gut microbiota;Host Defense;host-microbe interactions;Human;human disease;Ileitis;Immune system;Impairment;Inflammation;Inflammatory Bowel Diseases;innovation;insight;Integration Host Factors;Intestinal Diseases;intestinal epithelium;intestinal homeostasis;Intestines;Knowledge;Lead;Lipids;Literature;Methods;microbial;microbial homeostasis;microbiome;microbiome alteration;microbiota;microbiota metabolites;Modeling;Molecular;mouse model;Mucositis;Mus;Natural Immunity;novel;novel strategies;Organoids;overexpression;Paneth Cells;Pathogenesis;pathogenic bacteria;Patients;Physiology;Play;Predisposition;prevent;Process;Proteins;Qualifying;receptor;Regulation;Relapse;Research;Role;Salmonella;Sampling;Severities;Shapes;Signal Pathway;Signal Transduction;single cell technology;Small Intestines;Source;stem cells;Technology;Tissues;Transgenic Mice;Ulcerative Colitis;Vitamin D;Vitamin D3 Receptor

PROJECT_TITLE: Vitamin D Receptor Regulation of Microbiota in Intestinal Epithelia

STUDY_SECTION: DHMI

STUDY_SECTION_NAME: Digestive System Host Defense, Microbial Interactions and Immune and Inflammatory Disease Study Section[DHMI]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Data Science;Networking and Information Technology R&D (NITRD)

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Project Narrative - Public Health Relevance Statement: To encourage the creation of new research partnerships and to promote career path development, we will host a unique Biomedical Data Science Innovation Lab program focused on large-scale biomedical data to address salient challenges in health and disease. This event will follow a rigorous, interactive, mentored, and facilitated online and in-person program for data science skills training where novel team projects will be developed for NIH/NSF grant submissions. 1

PI_NAMEs: VAN HORN, JOHN DARRELL (contact)

PROGRAM_OFFICER_NAME: STOKES, KALYNDA K

PROJECT_TERMS: Acceleration;Address;analytical method;Applications Grants;Area;big biomedical data;Biological;biomedical data science;Biomedical Research;Biophysics;career;Career Choice;Clinical;Collaborations;Communities;community building;computer science;Computers;Creativeness;Data;Data Analytics;data modeling;Data Science;data science education;Dedications;Dependence;Development;Discipline;Disease;Education Projects;Educational workshop;Engineering;Ensure;Epidemiology;Evaluation;Event;Exposure to;Faculty;faculty mentor;Feedback;follow-up;Foundations;Funding;Funding Agency;Funding Mechanisms;Generations;Goals;Grant;Health;Human;innovation;interest;Knowledge;large scale data;Leadership;Learning;mathematical model;mathematical sciences;Mathematics;Measures;member;Mentors;Mentorship;Methods;mid-career faculty;Modeling;Modernization;multidisciplinary;next generation;novel;Outcome;outreach;Participant;Persons;Physics;Postdoctoral Fellow;Privatization;Process;Program Development;program dissemination;programs;public health relevance;Questionnaires;Reproducibility;Research;Research Personnel;Research Project Grants;Research Proposals;Research Training;responsible research conduct;Science;Scientist;senior faculty;Senior Scientist;Series;skills;skills training;social engagement;Social Network;Source;statistics;success;System;tenure track;Thinking;Time;tool;Training;Training Activity;Training and Education;trend;United States National Institutes of Health;Use Effectiveness;virtual;Vision;visual media;Visualization;web site;Woman

PROJECT_TITLE: Biomedical Data Science Innovation Labs: An Intensive Research Project Development Program


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Breastfeeding, Lactation and Breast Milk;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Microbiome;Nutrition;Obesity;Pediatric;Prevention

ORG_CITY: OAKLAND

ORG_DEPT: NUTRITION

ORG_STATE: CA

PHR: Project Narrative In the U.S. it is recommended that young children consume whole-fat cow’s milk when they are 1 year old and then transition to low-fat (1%) or non-fat milk beginning at age 2 years to reduce calorie intake for obesity prevention. However, these recommendations are not based on rigorous trials, and the existing observational studies suggest that higher fat milk consumption throughout childhood may in fact be associated with reduced adiposity. To inform dietary recommendations and federal nutrition policy, we propose a 1-year randomized controlled trial to test the impact of milk type (whole versus 1%) on adiposity (waist-to-height ratio, body mass index, tri-ponderal mass index, and waist circumference), dietary intake (energy, total and saturated fat, added sugars, overall diet quality), vitamin D status, cardiometabolic health (blood lipids, glucoregulatory indices), neurocognitive development, and microbiota, based on baseline and follow-up assessments in 500 children followed from 2 to 3 years of age. 1

PI_NAMEs: PATEL, ANISHA INDRAVADAN;RITCHIE, LORRENE D (contact)

PROGRAM_OFFICER_NAME: EVANS, MARY

PROJECT_TERMS: 1 year old;2 year old;3 year old;5 year old;Adolescent obesity;Adult;adult obesity;Affect;Age;Appetite Regulation;blood lipid;Body mass index;Brain;Calories;Cardiometabolic Disease;cardiometabolism;Caring;Cattle;Characteristics;Child;Childhood;Clinical;comorbidity;Consumption;Development;Diet;dietary;Dietary intake;disorder risk;drinking;Energy Intake;Ensure;Epidemic;Essential Fatty Acids;evidence base;excessive weight gain;Fatty acid glycerol esters;follow up assessment;follow-up;Food;Growth;Guidelines;gut microbiota;Health;Health Personnel;Height;Home;Hormones;Household;Human Milk;indexing;infancy;Infant;Insulin Resistance;Intake;Leptin;Measurement;Measures;Metabolic;microbiota;microbiota composition;Milk;milk fat;milk intake;Neurocognitive;Nursery Schools;Nutrient;nutrition;Nutrition Policy;Obesity;obesity in children;obesity prevention;Observational Study;Outcome;Outcome Study;Overweight;Parents;Participant;pediatrician;Policies;Preschool Child;Prevalence;primary outcome;programs;Proteins;Public Health;Randomized;Randomized, Controlled Trials;Recommendation;recruit;Risk Factors;Role;Satiation;saturated fat;School-Age Population;secondary outcome;Source;Standardization;sugar;Surveys;Testing;Time;Toddler;Underweight;Vitamin D;waist circumference;Weight;Woman

PROJECT_TITLE: Milk Type in Toddlers (Milk-TOT) Study: Impact of Whole versus Low-fat Milk on Child Adiposity, Health and Development

STUDY_SECTION: HSDO

STUDY_SECTION_NAME: Human Studies of Diabetes and Obesity Study Section[HSDO]


NIH_SPENDING_CATS: Cancer;Cervical Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Radiation Oncology;Women's Health Research

ORG_CITY: LA JOLLA

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE This proposal describes my 13 yr. long-standing qualifications and contributions for NCI funded clinical trials though my leadership within the NRG Oncology network as former co-chair of the GYN developmental therapeutics phase I committee, current co-chair of the cervix committee, service as a core and executive committee member, principal investigator status on two early phase clinical trials in cervical cancer with novel translational outcomes, and my development of new clinical trials through strategy. I am a clinical trials leader as GYN co-chair at my institution, UCSD, Moores Cancer Center (MCC), which has a strong, well-established National Cancer Clinical Trials program with over 265 therapeutic treatment trials open. My clinical trial research focuses on health care disparities and increasing underrepresented minority accrual and representation as a PI on national clinical trials through extensive mentorship within the NRG Oncology for junior investigators.

PI_NAMEs: MAYADEV, JYOTI  (contact)

PROGRAM_OFFICER_NAME: LINDWASSER, ONN WOLF

PROJECT_TERMS: anti-PD-L1;Area;Award;biomarker driven;Board Certification;California;Cancer Center;cancer clinical trial;Cervix Uteri;chemoradiation;Clinical;clinical trial enrollment;Clinical Trials;Committee Members;community engagement;Community Outreach;Development;Developmental Therapeutics Program;early phase clinical trial;Early Therapeutic-Clinical Trials Network;Ensure;Equity;Female;Female Genital Diseases;Funding;Goals;Grant;Gynecologic;Gynecologic Oncology Group;health care disparity;high risk;Immune;improved;Information Dissemination;Institution;ipilimumab;K-Series Research Career Programs;Leadership;Malignant neoplasm of cervix uteri;Medicine;member;Mentors;Mentorship;Molecular;novel;Oncology;Oncology Group;Outcome;Patients;Phase;phase I trial;Positive Lymph Node;Principal Investigator;professor;programs;Qualifying;Radiation;Radiation Oncologist;Radiation Oncology;Rebecca and John Moores UCSD Cancer Center;Research;Research Personnel;Role;Sampling;Services;Testing;Therapeutic;Therapeutics Committee;translational clinical trial;Translational Research;treatment trial;Underrepresented Minority;Underserved Population;Universities;Writing

PROJECT_TITLE: NCI Clinical Trial Research Strategy, Harnessing of Equity, and Implementation


ORG_CITY: UNIVERSITY PARK

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

ORG_STATE: PA

PHR: Microbiome plays a critical role in various diseases and conditions, such as asthma, diabetes, obesity, autism, skin diseases, infant growth, and so on. The new statistical methods and software developed in this project can be applied to microbiome studies of these diseases to gain biological and biomedical insights into the complex microbiome-disease relationships. A better understanding of the microbiome mechanism will lay the foundation for advances in disease diagnosis, treatment, and prevention.

PI_NAMEs: XUE, LINGZHOU  (contact);YU, XIUFAN

PROGRAM_OFFICER_NAME: WANG, PEGGY

PROJECT_TERMS: 16S ribosomal RNA sequencing;analytical tool;Asthma;autism spectrum disorder;Biological;biomarker discovery;cancer biomarkers;Clinical;combat;Communities;Complex;Computer software;computerized tools;Data;data structure;Dependence;design;Diabetes Mellitus;Diagnostic;Disease;disease diagnosis;Foundations;Genetic Markers;genome wide association study;Growth;Health;high dimensionality;High-Throughput Nucleotide Sequencing;Human;improved;Infant;insight;interest;Learning;Maps;Mediation;metabolomics;Metagenomics;Methodology;microbial;microbial community;microbiome;microbiome analysis;microbiome research;microbiome therapeutics;Molecular Epidemiology;National Institute of General Medical Sciences;Nature;Obesity;Outcome;Pattern;Phylogenetic Analysis;Play;Prevention;prognostic;Research;Research Personnel;Role;Sample Size;Shotgun Sequencing;skin disorder;software development;Statistical Methods;Structure;Surveys;Technology;theories

PROJECT_TITLE: Collaborative Research: DMS/NIGMS 2: New statistical methods, theory, and software for microbiome data


ADMINISTERING_IC: HL

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: LOS ANGELES

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: OVERALL: Sex Differences in the Cardiometabolic Health and Disease NARRATIVE Men and women differ in their risk for the development of cardiometabolic diseases, and in their response to widely used preventive drugs. We are dedicated to understanding the reasons for these sex differences, and will study the effects of hormones and genetic factors. Our studies will allow the development of therapies that will optimally benefit both women and men.

PI_NAMEs: REUE, KAREN  (contact)

PROGRAM_OFFICER_NAME: SHI, YANG

PROJECT_TERMS: adipocyte differentiation;Adverse effects;Bioinformatics;Biological;Biological Models;Cardiac;Cardiac Myocytes;Cardiometabolic Disease;cardiometabolism;Cardiomyopathies;Cardiotoxicity;Cardiovascular Diseases;career;Cell Line;cell type;Collaborations;Communication;Computer Analysis;Coronary;Coronary Arteriosclerosis;Coronary artery;Data;Data Set;Dedications;Development;Diagnosis;diet-induced obesity;Disease;disorder risk;Dissection;EFRAC;Ensure;Enzymes;Epigenetic Process;epigenetic regulation;ESR1 gene;Estrogen Receptors;Estrogens;Experimental Models;Female;Fostering;Genes;Genetic;genetic approach;Genetic Variation;Genomics;Goals;Gonadal Hormones;Grant;Health;Heart failure;heart function;histone demethylase;Hormones;Human;human data;Human Genetics;human induced pluripotent stem cells;human model;improved;Individual;insight;Investigation;knock-down;Knock-out;Laboratories;Leadership;Libraries;meetings;men;Metabolism;metabolomics;Microvascular Dysfunction;Mitochondria;mitochondrial dysfunction;mitochondrial metabolism;Molecular;mortality;mouse model;Mouse Strains;Mus;Mutation;Myocardial Infarction;Obesity;Operations Research;overexpression;patient derived induced pluripotent stem cells;Pharmaceutical Preparations;Population;pre-clinical;Predisposition;preservation;Prevalence;Prevention;Preventive;Process;programs;Proteomics;Publishing;Research;Research Personnel;Research Project Grants;response;Risk;Role;Series;sex;Sex Bias;Sex Chromosomes;Sex Differences;Stress cardiomyopathy;Stroke;Students;symposium;System;Testing;therapeutic development;therapy development;Tissues;trait;transcriptomics;Translating;Woman;women versus men;Y Chromosome

PROJECT_TITLE: Sex Differences in Cardiometabolic Health and Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-EMS-A(70)R]


NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Clinical Research;Diabetes;Genetics;Heart Disease;Human Genome;Nutrition;Obesity;Prevention;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Women's Health Research

PHR: PROJECT 1: Epigenetic sex determinants of cardiometabolic disease and prevention NARRATIVE Women and men differ in the development of cardiovascular disease risk factors such as obesity, and women are more likely than men to experience adverse effects from statin drugs. We have identified genes on the X and Y chromosomes that work in conjunction with hormones such as estrogen and testosterone to influence obesity and vulnerability to statin drug side effects. A better understanding of how these X and Y chromosome genes regulate obesity and drug response will contribute to development of therapies that optimally benefit both women and men.

PROJECT_TERMS: Address;adipocyte differentiation;Adipocytes;Adipose tissue;Adverse effects;Adverse event;Area;Binding Sites;Bioinformatics;Biology;Body Composition;Cardiometabolic Disease;cardiometabolism;Cardiovascular Diseases;cardiovascular disorder prevention;cardiovascular disorder risk;Cell Line;Cells;Childhood;Chromatin;Chromosomes;Collaborations;Conceptions;Data;Development;Diabetes Mellitus;differential expression;Disease;dosage;Drug Prescriptions;Drug Side Effects;Dyslipidemias;Embryo;energy balance;Enhancers;Enzymes;Epigenetic Process;epigenetic regulation;epigenomics;Estrogens;Exhibits;Female;Fetus;Gene Dosage;Gene Expression Regulation;Genes;Genomics;Goals;gonad development;Gonadal Hormones;Health;histone demethylase;histone methylation;Histones;Hormones;Human;human female;Human Genetics;human induced pluripotent stem cells;human male;In Vitro;in vivo;induced pluripotent stem cell;Length;lipid biosynthesis;male;men;mitochondrial dysfunction;Modification;Molecular;mouse model;multiple omics;Mus;Obesity;obesity development;optimal treatments;Outcome;patient derived induced pluripotent stem cells;Pharmaceutical Preparations;Physiological;Ploidies;Prevalence;prevent;Prevention;Preventive treatment;promoter;Puberty;Regulation;Research Personnel;Resources;response;Risk Factors;Role;sex;Sex Bias;Sex Chromosomes;Sex Differences;Tail;Testosterone;therapy development;trait;transcription factor;transcriptome;transcriptomics;Translating;translation to humans;Woman;Work;X Chromosome;Y Chromosome

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-EMS-A]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Genetics;Heart Disease;Women's Health Research

PHR: Project 2: Gene-by-sex interactions in heart failure with preserved ejection fraction (HFpEF) PROJECT NARRATIVE Heart failure with preserved ejection fraction accounts for 50% of all heart failure. It exhibits a strong sex bias, with about two-thirds of patients being women. We will dissect the basis of this sex difference using systems genetics approaches in mice as well as validation of hypotheses in human cohorts.

PI_NAMEs: LUSIS, ALDONS JAKE (contact)

PROJECT_TERMS: Affect;Bioinformatics;Biological;Cardiac Function Study;Cardiac Myocytes;cardiometabolism;Chromosomes;Clinical;cohort;Collaborations;comorbidity;Complex;coronary fibrosis;Data;Diabetes Mellitus;Diagnosis;Disease;disease model;EFRAC;Environmental Risk Factor;Enzymes;epidemiologic data;ESR1 gene;Estrogens;Exhibits;feeding;Female;Four Core Genotypes;Functional disorder;Genes;Genetic;genetic analysis;genetic approach;Genetic study;Genetic Variation;Goals;Gonadal Steroid Hormones;Health;Heart;Heart failure;heart failure with reduced ejection fraction;heart function;Heart Mitochondria;High Fat Diet;Hormonal;Hormones;Human;Hybrids;Hypertension;Inbred Strains Mice;Inflammation;interest;Kidney Diseases;Knockout Mice;Laboratories;Left ventricular structure;loss of function;male;Maps;member;men;Mitochondria;Mitochondrial Proteins;Modeling;Molecular;Molecular Analysis;mouse model;Mus;Nature;Nitric Oxide Synthetase Inhibitor;Obesity;Pharmaceutical Preparations;Predisposition;preservation;programs;Resources;Role;sex;Sex Bias;Sex Chromosomes;Sex Differences;Statistical Models;Structure;Symptom Burden;Syndrome;System;Technology;Testing;Tissues;trait;Translating;Validation;Woman;women patients


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Dietary Supplements;Digestive Diseases;Genetics;Liver Disease;Prevention

PHR: Project Narrative Drug induced liver injury (DILI) is a rare but serious problem that can lead to liver failure, transplantation, death, or chronic liver disease. Drug induced liver injury network (DILIN) was set up by the National Institutes of Health in 2003 to facilitate clinical, mechanistic and therapeutic research related to DILI. Indiana University is proposing several novel specific aims to promote DILIN during the next funding period.

PI_NAMEs: CHALASANI, NAGA P (contact)

PROGRAM_OFFICER_NAME: SHERKER, AVERELL H

PROJECT_TERMS: acute drug induced liver toxicity;acute liver injury;Address;Adult;Agonist;Alkaline Phosphatase;Ambulatory Care Facilities;Ancillary Study;anti-epileptic agents;Attenuated;Bilirubin;Biological;cell type;Cells;Cessation of life;Cholestasis;Chronic;chronic liver disease;Clinical;clinical application;clinical center;cohort;County Hospitals;COVID-19 vaccination;Data;Data Coordinating Center;data integration;Development;dietary supplements;Double-Blind Method;drug induced liver injury;Electronic Health Record;Eligibility Determination;Enrollment;Epidemiology;epidemiology study;Epigallocatechin Gallate;ethnic diversity;Etiology;exome sequencing;follow-up;Funding;Funding Opportunities;Gastroenterology;Genes;Genetic;genetic variant;genome wide association study;Goals;Health;Health care facility;Healthcare;Hepatocyte;Herbal supplement;Hospitals;Immunotherapeutic agent;improved;Indiana;Individual;Infrastructure;Intervention;Investigation;Knowledge;large datasets;Link;Liver Failure;liver injury;Medical Informatics;meetings;Messenger RNA;Methodology;Molecular;Morbidity - disease rate;mortality;Multiple Trauma;Natural History;Nitrofurantoin;novel;operation;Outcome;Pathway interactions;Patient-Focused Outcomes;Patients;Pharmacogenetics;Phenotype;Pilot Projects;Placebo Control;Placebos;Plasma;PPAR alpha;Primary biliary cirrhosis;Privatization;Probability;prospective;Prospective Studies;Protocols documentation;Pruritus;Publications;Quality of life;racial diversity;Randomized;Recovery;recruit;Research;Research Personnel;Retrospective Studies;Risk Factors;risk variant;Safety;Serious Adverse Event;Serum;Severities;Source;Stethoscopes;tertiary care;Testing;Therapeutic;Therapeutic Research;Tissues;total measurement Bilirubin;transcriptome;transcriptome sequencing;Transplantation;Trimethoprim-Sulfamethoxazole;Underrepresented Minority;United States National Institutes of Health;Universities;Variant

PROJECT_TITLE: IU Clinical Center: Drug Induced Liver Injury Network


NIH_SPENDING_CATS: Aging;Biotechnology;Breast Cancer;Cancer;Cardiovascular;Estrogen;Genetics;Heart Disease;Menopause;Nutrition;Women's Health Research

PHR: Project 3: The impact of estrogen receptor alpha on cardiomyocellular metabolism and health PROJECT NARRATIVE Cardiometabolic dysfunction and the incidence of chronic disease increase markedly in women following menopause. However, the role of estrogen action and the mechanisms underlying the preservation of cardiometabolic health are inadequately understood. We intend for our work to provide mechanistic insight into novel strategies to combat heart failure in women.

PI_NAMEs: HEVENER, ANDREA L (contact)

PROJECT_TERMS: Aerobic;Age;aging related;Animals;Antineoplastic Agents;Architecture;ATP Synthesis Pathway;Breast Cancer Patient;Calcium;Cardiac;Cardiac Myocytes;Cardiac Output;Cardiometabolic Disease;cardiometabolism;Cardiomyopathies;Cardiotoxicity;Carnitine;cell type;Cells;Chemotherapy-Oncologic Procedure;Chronic Disease;Clinical;Collaborations;combat;comparative;Complex;Complication;Crista ampullaris;Cytochrome c Reductase;Data Set;density;Deuterium;Disease;disorder risk;Dissection;DNA Damage;Doxorubicin;EFRAC;ESR1 gene;Estradiol;Estrogen Receptors;Estrogens;Exercise Tolerance;Fatty acid glycerol esters;fatty acid metabolism;fatty acid oxidation;feeding;Fibrosis;Functional disorder;Funding;Genes;Genome;Genus Hippocampus;Goals;Health;Heart;Heart failure;heart function;heart metabolism;High Fat Diet;Homeostasis;human subject;Immune;Impairment;improved;in vivo;Incidence;Inflammation;insight;Insulin Resistance;insulin sensitivity;Iron;Isoproterenol;Isotopes;knock-down;Knockout Mice;Label;Laboratories;Life;Link;lipid metabolism;Liver;Malignant Breast Neoplasm;Membrane;men;Menopause;Metabolic;Metabolism;metabolomics;Mitochondria;Mitochondrial DNA;mitochondrial dysfunction;mitochondrial metabolism;Mitochondrial Proteins;Molecular;mouse model;Mus;Muscle;Mutation;Myocardial dysfunction;novel;novel strategies;Nuclear;Obesity;Outcome;overexpression;Pathogenicity;Pathology;Pathway Analysis;Pathway interactions;Perimenopause;Phase;Phenotype;Postmenopause;Predisposition;Premature Menopause;preservation;prevent;Proteins;Proteome;Proteomics;proteostasis;Purines;Quality Control;Radiolabeled;Regulation;Reporting;Research;Respiratory Chain;Ribonucleotides;Risk;Role;Sex Differences;Skeletal Muscle;Specificity;targeted treatment;Testing;Tissues;tool;Transcript;transcriptome;transcriptome sequencing;transcriptomics;VO2max;Woman;Women's Health;Work


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Neurosciences;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: BIRMINGHAM

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE Opioid use disorder is frequently accompanied by chronic alcohol use, yet preclinical models of polydrug opioid and alcohol use are lacking. This project will determine the basic mechanisms underlying heroin seeking after comorbid alcohol use, with a focus on the prefrontal cortex, a key brain site whereby drugs highjack decision- making. These studies will lay the groundwork for understanding how prefrontal receptors and circuits are differentially impacted by opioid use versus opioid use with chronic comorbid alcohol use, thus guiding treatment strategies in individuals with a polydrug use history.

PI_NAMEs: PETERS, JAMIE  (contact)

PROGRAM_OFFICER_NAME: ANANTHAN, SUBRAMANIAM

PROJECT_TERMS: Acute;Addictive Behavior;Agonist;alcohol comorbidity;Alcohol consumption;alcohol exposure;alcohol seeking behavior;alcohol use disorder;Alcohols;Animals;antagonist;Basic Science;Brain;Buprenorphine;cell type;Chronic;chronic alcohol ingestion;Clinical Research;cocaine seeking;cognitive function;comorbidity;Cues;Data;Decision Making;Disease;drug craving;drug relapse;Drug usage;druggable target;Electrophysiology (science);endogenous opioids;executive function;Exhibits;Extinction;FDA approved;Frequencies;Functional disorder;Genetic;Goals;Heroin;heroin use;hippocampal pyramidal neuron;Home;HTR2A gene;Human;Individual;innovation;insight;Interneurons;Light;Measures;Medial;Methadone;Modeling;Motivation;mu opioid receptors;multiple drug use;Naloxone;Naltrexone;neuroadaptation;neuronal excitability;Neurons;neurophysiology;novel;Nucleus Accumbens;Opioid;opioid exposure;Opioid Receptor;Opioid Rotation;opioid use;opioid use disorder;opioid withdrawal;Outcome Measure;Output;Pathway interactions;Patients;Pharmaceutical Preparations;Physiological Adaptation;Play;polysubstance use;Population;Positioning Attribute;Pre-Clinical Model;preclinical study;Prefrontal Cortex;Public Health;Publishing;receptor;Recording of previous events;Regulation;Relapse;Reporting;Research;Rodent;Role;Self Administration;Serotonin;Serotonin Receptor 5-HT2A;Severities;Site;Slice;stimulant use;Substance Use Disorder;System;Testing;Therapeutic;therapeutic evaluation;therapeutic opioid;therapeutic target;Treatment Efficacy;treatment strategy;United States

PROJECT_TITLE: Prefrontal mechanisms underlying polydrug heroin and alcohol use


NIH_SPENDING_CATS: Women's Health Research

PHR: Leadership Administrative Core RELEVANCE TO PUBLIC HEALTH Men and women differ in the prevalence and disease course of common cardiometabolic disorders such as obesity and several cardiovascular diseases. Our investigators are dedicated to understanding the reasons for these sex differences so that both men and women can receive more effective diagnoses and treatments for these conditions.

PROJECT_TERMS: Administrative Efficiency;Advisory Committees;Award;Bioinformatics;biological sex;Brain;Budgets;Cantor;Cardiac health;Cardiometabolic Disease;cardiometabolism;Cardiovascular Diseases;career;career development;Collaborations;Collection;Consultations;Dedications;Development;Diagnosis;Disease;Doctor of Philosophy;Education;Educational Activities;Educational workshop;Ensure;Event;Feedback;Fostering;Funding;Goals;gut microbiome;Health;health organization;Human;Human Genetics;Individual;Iris;Irritable Bowel Syndrome;Leadership;male health;meetings;men;Metabolism;Monitor;Obesity;Office of Administrative Management;Pilot Projects;posters;Preparation;Prevalence;Productivity;programs;Progress Reports;Public Health;Research;Research Personnel;Research Project Grants;Resource Sharing;Resources;Risk;Role;Scientist;Sex Differences;symposium;synergism;Woman;Women's Health;Work

PROJECT_TITLE: Leadership Administration Core


NIH_SPENDING_CATS: Behavioral and Social Science;Genetics;Prevention;Sleep Research

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Irregular sleep is highly prevalent and linked to the development of adverse health outcomes, yet it is also highly modifiable, representing an important public health target. Here, we seek to characterize and validate dimensions of naturalistic light exposure that affect sleep regularity and blood-based markers of sleep regularity. This research has the potential to advance the field by investigating the contribution of environmental light, an important but underexamined exposure, to sleep health and identify relevant markers to inform sleep health in the general population.

PI_NAMEs: WALLACE, DANIELLE A. (contact)

PROGRAM_OFFICER_NAME: BAIZER, LAWRENCE

PROJECT_TERMS: actigraphy;Address;Affect;Age;Area;Award;Behavior;Biological;Biological Markers;blood-based biomarker;Body Temperature;candidate identification;cardiometabolism;career;career development;Chronobiology;circadian;Circadian desynchrony;Clinical;cohort;Cohort Studies;Communities;community setting;Cues;Data;Data Analyses;Data Collection;Development;Development Plans;Dimensions;Disease;disorder prevention;DNA Methylation;Drowsiness;Environment;Environmental Exposure;Environmental Health;Environmental Risk Factor;Epidemiology;Epigenetic Process;Foundations;General Population;Genetic Materials;genome-wide;Goals;Grant;Health;Health Promotion;Health Status;Heart Rate;high dimensionality;Hispanic Community Health Study/Study of Latinos;Humidity;improvement on sleep;Interdisciplinary Study;Intervention;Knowledge;Light;Linear Models;Link;Measurement;Measures;Mentors;methylation biomarker;methylation pattern;Modeling;Molecular Epidemiology;molecular marker;multi-ethnic;Multi-Ethnic Study of Atherosclerosis;Mutation;Noise;Non-linear Models;novel;Outcome;Participant;Pathway interactions;Patient Recruitments;Pattern;Phase;Population;population health;Printing;programs;prospective;Prospective cohort;Proxy;Public Health;public health intervention;Recording of previous events;Reporting;Research;Research Personnel;Role;secondary analysis;sex;shift work;Site;Sleep;Sleep Deprivation;Sleep disturbances;sleep health;Statistical Data Interpretation;Statistical Models;successful intervention;Sum;System;Temperature;tool;Training;United States National Institutes of Health;Vision research;Work

PROJECT_TITLE: Investigating relationships between naturalistic light exposure and sleep


PHR: Career Enhancement Core NARRATIVE The Career Enhancement Core (CEC) will provide an integrated set of educational and research support activities at UCLA to foster development of research at UCLA in women's health and sex as a biological factor in disease (WH/SABVD), especially related to sex differences in the metabolic syndrome. Among the activites of the CEC are a Pilot and Feasibility pilot grant program for UCLA investigators, teaching early-stage and advance undergraduate SABV courses at UCLA, producing the UCLA SABV Video Library streaming videotaped lectures on SABV for free distribution worldwide, and programs to recruit under-represented minority students to research in this field.

PI_NAMEs: ARNOLD, ARTHUR P (contact)

PROJECT_TERMS: Acceleration;Affect;Animal Disease Models;animal resource;apprenticeship;Area;Awareness;cardiometabolism;career;Communities;Consult;Consultations;Data;Development;Disease;doctoral student;Education;Educational process of instructing;Enrollment;experience;Faculty;Fostering;Funding;Future;Goals;Gonadal Hormones;Grant;Health;Incubated;Individual;International;Internet;Knowledge;Laboratories;Laboratory Research;Lead;Learning;lectures;Libraries;medical schools;meetings;member;Metabolic syndrome;Methods;Modeling;novel;Occupations;Peer Review;Physicians;Physiology;Preparation;programs;recruit;Research;research and development;Research Personnel;Research Project Grants;Research Support;Resources;Scientific Societies;Scientist;sex as a biological variable;Sex Bias;Sex Chromosomes;Sex Differences;Stream;Students;Translational Research;undergraduate education;undergraduate student;Underrepresented Minority;underrepresented minority student;United States National Institutes of Health;Universities;Videotape;Women's Health;Women's study

PROJECT_TITLE: Career Enhancement Core


NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Clinical Research;Data Science;Dissemination and Implementation Research;Heart Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Organ Transplantation;Transplantation

ORG_CITY: CHARLESTON

ORG_DEPT: SURGERY

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: NARRATIVE Although 250,000 patients with end-stage heart failure may benefit from heart transplantation, only 3,500 are performed annually in the US due to donor shortages, with recent data also demonstrating that higher risk recipients are being transplanted with declining post-transplant survival rates nationally. Clinicians lack data- driven decision support tools to assess donor quality and match suitable donors with appropriately selected recipients. This work seeks to create high quality predictive models for heart transplantation using machine learning to assist transplant providers in their ability to efficiently select and match donors and recipients, as well as to inform allocation policy, thereby expanding donor utilization, accelerating the pace of time-sensitive clinical decision-making, optimizing allocation of scarce resources, and improving outcomes.

PI_NAMEs: KILIC, ARMAN  (contact)

PROGRAM_OFFICER_NAME: ANAYA, GABRIEL

PROJECT_TERMS: Acceleration;Address;Adoption;Adult;Artificial Intelligence;Clinical;clinical candidate;clinical decision-making;clinically relevant;Complex;Computer Analysis;Computer Simulation;Data;data registry;Data Set;Decision Making;Decision Support Model;Decision Support Systems;Development;Evaluation;experience;Face;Failure;FAIR principles;Future;Goals;Heart;Heart failure;Heart Transplantation;high risk;Human;implementation science;implementation strategy;improved;improved outcome;Individual;innovation;Judgment;Machine Learning;machine learning method;machine learning model;Modeling;mortality risk;Multicenter Trials;novel;open data;Organ;Outcome;Output;Patients;Performance;personalized decision;Policies;Policy Maker;Policy Making;post-transplant;Predictive Analytics;predictive modeling;Preparation;Process;programs;prototype;Provider;Reporting;Research;Resources;Risk;risk prediction;Specific qualifier value;statistics;stem;success;support tools;Survival Rate;Technology Assessment;Time;tool;transplant centers;transplant database;Transplant Recipients;Transplantation;trend;usability;Visual;Waiting Lists;web-based tool;Work

PROJECT_TITLE: Developing Machine Learning Models for Decision Support and Allocation Optimization in Heart Transplantation

STUDY_SECTION: CDMA

STUDY_SECTION_NAME: Clinical Data Management and Analysis Study Section[CDMA]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Clinical Research;Genetics;Human Genome;Women's Health Research

PHR: PROJECT NARRATIVE The overall objective of Center is to use a series of basic science experiments to understand how risk for cardiometabolic diseases differs between men and women. The role of the Human Translational Bioinformatics Core will be to serve as the hub for computational analyses that translate findings from the experimental projects for association and relevance to cardiometabolic traits in humans. These cost-effective and efficient analyses may, in turn, reveal additional biological information and lead to new hypotheses that can be investigated experimentally.

PI_NAMEs: ALLAYEE, HOOMAN  (contact)

PROJECT_TERMS: analytical tool;Basic Science;Bioinformatics;Biological;Biological Markers;Biological Models;biomarker identification;Candidate Disease Gene;candidate identification;Cardiometabolic Disease;cardiometabolic risk;cardiometabolism;Cells;Clinical;Clinical Research;cohort;Communities;Computer Analysis;computer infrastructure;Computer software;Coronary Arteriosclerosis;cost effective;Data;Data Set;Databases;Disease;Ensure;Epidemiology;experience;experimental study;Gene Modified;Genes;Genetic;genetic association;Genetic Complementation Test;Genetic study;genome wide association study;Genomics;Genotype;Goals;Health;Hospitals;Human;Human Activities;human data;Human Resources;in silico;In Vitro;Inbred Strains Mice;Intuition;Knowledge;large scale data;Leadership;men;metabolomics;Molecular;mouse model;Multiomic Data;multiple data sources;Mus;online resource;Online Systems;open source tool;Outcome;Pathway interactions;phenome;Population;programs;Proteomics;Publishing;Research;Research Personnel;Resources;Risk Factors;Role;Sample Size;searchable database;Series;Sex Differences;sexual dimorphism;success;System;Systems Biology;targeted biomarker;tool;trait;transcriptomics;Translating;Update;Validation;Variant;Visualization software;web based interface;Woman

PROJECT_TITLE: Human Translational Bioinformatics Core


ADMINISTERING_IC: MH

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Mental Health;Pediatric

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE. Our understanding of social media as a key developmental context for adolescent mental health is currently limited by a focus on average effects across individuals and time. Innovation is needed to move beyond average effects to identify who is at risk (or can benefit), via what type of social media interpersonal experiences, when in real-time or development, and by which pathway risk escalates or remits. In this project we will, (1) chart real-time links in differential susceptibility to positive and negative online social experiences across individuals, (2) test whether short term effects accumulate over time to amplify or buffer risk for psychopathology, and (3) identify the relative developmental contributions of online vs. in-person socioemotional experiences to growth in psychopathology risk across adolescence.

PI_NAMEs: FOSTER, KATHERINE TATE (contact);MAGIS-WEINBERG, LUCIA

PROJECT_TERMS: Absenteeism at work;Acceleration;Address;Adolescence;Adolescent;adolescent mental health;Age;aged;Attention;Benefits and Risks;Buffers;Cellular Phone;Clinical;cohort;course development;Data;density;design;Development;Disease remission;Distress;early adolescence;Ecological momentary assessment;Emotional;emotional experience;Exclusion;Exhibits;experience;Exposure to;Goals;Growth;Heterogeneity;high risk;improved;Individual;innovation;insight;Intervention;Joints;Link;longitudinal design;media use;Methodology;Methods;Modeling;Nature;neglect;Outcome;Pathway interactions;peer;person centered;Persons;Predisposition;Prevention;Process;promote resilience;Psychopathology;rate of change;recruit;Research;Risk;Risk Factors;risk minimization;Role;Sampling;Signal Transduction;social;Social Environment;Social Interaction;social media;Social support;statistical center;Surveys;Techniques;Testing;Time;Variant;Well in self;Work;Youth

PROJECT_TITLE: Heterogeneity in joint real-time and developmental influences of positive and negative social media experiences on socioemotional vulnerability and psychopathology across adolescence


NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Neurosciences;Pediatric;Sleep Research

ORG_CITY: MIAMI

ORG_NAME: FLORIDA INTERNATIONAL UNIVERSITY

ORG_STATE: FL

PHR: Project Narrative There is a critical need to identify etiological mechanisms implicated in social anxiety to inform prevention efforts and guide treatment development. This R01 addresses this need by testing a mechanistic model of the relationship between social media use and social anxiety in adolescents ages 13 to 17 years, focusing on attention perturbations and key features of sleep disturbance as variables that impact risk. Findings of the proposed research are expected to identify modifiable targets that can be leveraged to prevent the escalation of social anxiety severity in the key developmental period of adolescence.

PI_NAMEs: PETTIT, JEREMY W (contact)

PROGRAM_OFFICER_NAME: THOMAS, LAURA ANDERSON

PROJECT_TERMS: Acceleration;actigraphy;Address;Adolescence;Adolescent;Age;Anxiety;anxiety symptoms;Attention;Behavior;cognitive development;cognitive neuroscience;Data;design;Development;Diagnostic;diaries;Ecological momentary assessment;Ethnic Population;Etiology;Exhibits;experience;Female;Frequencies;Future;Gatekeeping;Goals;Hispanic;Hour;insight;Instagram;Latinx;Literature;Location;longitudinal design;male;Measures;media use;Mediating;Mediator;member;Methods;Modeling;neurodevelopment;Patient Self-Report;Phase;poor sleep;Positioning Attribute;prevent;Prevention;Process;Reporting;Research;Risk;Severities;Shapes;Sleep;Sleep disturbances;sleep quality;social;social anxiety;Social Behavior;Social Development;social media;sustained attention;Symptoms;Testing;therapy development;Time;time use;vigilance;visual tracking;Work

PROJECT_TITLE: Testing a Mechanistic Model of Attention to Social Media Content and Sleep Disturbance in the Escalation of Social Anxiety in Adolescents


ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: Narrative The Mayo Clinic Breast Cancer SPORE addresses significant problems relating to breast cancer with the goal of reducing morbidity and mortality from the disease. This will be accomplished through projects focusing on breast cancer risk, prevention, and development of a novel approach to treat premenopausal ER+/HER2- breast cancer. The proposed research addresses vitally important issues to an enormous number of women both with, and at risk of, developing breast cancer.

PI_NAMEs: GOETZ, MATTHEW PHILIP (contact)

PROGRAM_OFFICER_NAME: BASA JANAKIRAM, NAVEENA

PROJECT_TERMS: Address;Adjuvant;age related;Antigen Targeting;Antigens;Aromatase Inhibitors;Benign;Bioinformatics;Biometry;Blood;bone;BRCA2 gene;Breast;Breast Cancer Prevention;Breast Cancer Risk Factor;breast cancer vaccine;Breast Diseases;cancer recurrence;cancer subtypes;career;Cell Cycle Progression;CHEK2 gene;Classification;Clinic;Clinical;Clinical Trials;clinically relevant;Collaborations;Colorectal;Contralateral Breast;CRISPR/Cas technology;Cyclin D1;Data;deprivation;Development;Diagnosis;Disease;DNA;Dose;Down-Regulation;Drug Targeting;E2F transcription factors;Economic Burden;Endocrine;ERBB2 gene;ESR1 gene;Estrogen receptor positive;Estrogens;Extramural Activities;faculty support;first-in-human;Funding;Future;Genes;Goals;High Risk Woman;high throughput screening;hormone therapy;Immune response;Immunologic Markers;improved;in vivo;Incidence;innovation;instrument;Knock-in;Laboratories;Leadership;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Gland Parenchyma;Mayo Clinic Cancer Center;Medical;Mentors;Methodology;Morbidity - disease rate;mortality;National Surgical Adjuvant Breast and Bowel Project;novel;novel strategies;novel therapeutics;novel vaccines;Oncogenic;Organ;Ovarian;PALB2 gene;Pancreas;Pathogenicity;Pathology;patient registry;Performance;phase 1 study;Phase III Clinical Trials;population based;Positioning Attribute;premalignant;Premenopause;Prevention;Prevention strategy;Principal Investigator;Prognosis;prognostic;programs;Protein Degradation Induction;Proteins;RAD51C gene;Recommendation;Reproduction spores;Research;Research Personnel;Research Project Grants;response;Risk;Risk Assessment;Sampling;Science;Scientist;Second Primary Cancers;success;Susceptibility Gene;Systemic Therapy;Tamoxifen;Translating;translational cancer research;Translational Research;translational research program;treatment response;tumor;United States National Institutes of Health;Uterus;Vaccine Antigen;Vaccine Clinical Trial;vaccine trial;Vaccines;Variant;variant of unknown significance;Vision;Woman;women's prevention;Work

PROJECT_TITLE: Mayo Clinic Breast Cancer SPORE


NIH_SPENDING_CATS: Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Women's Health Research

PHR: NARRATIVE The Administration Core provides the organizational infrastructure necessary to perform the work proposed in this SPORE application.

PROJECT_TERMS: Advisory Committees;Advocacy;Advocate;anti-cancer research;Breast;career;career development;Clinic;Collaborations;Communication;Development;Extramural Activities;Funding;Future;Goals;Human Resources;Infrastructure;innovation;instrument;Leadership;Malignant Breast Neoplasm;Malignant Neoplasms;Mayo Clinic Cancer Center;meetings;Monitor;National Cancer Institute;operation;Organ;Performance;Positioning Attribute;Production;Program Development;programs;Progress Reports;Reporting;Research;Research Personnel;Research Project Grants;Research Support;Scientist;Structure;translational cancer research;Translational Research;translational research program;United States National Institutes of Health;Visit;Woman;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Genetic Testing;Genetics;Prevention;Women's Health Research

PHR: PROJECT NARRATIVE The risk estimates for primary and contralateral breast cancers associated with pathogenic variants (PVs) in estrogen receptor positive breast cancer predisposition genes for women of all ages from the general population and high-risk population will substantially improve risk assessment and management of these individuals. Reclassification of variants of uncertain significance in these genes as pathogenic or benign will also improve the utility of genetic testing results. Furthermore, determination of the influence of PVs in ER-positive predisposition genes on disease free survival and overall survival in response to adjuvant therapy and whether these PVs are correlated with Oncotype Dx Breast Recurrence Scores will provide substantial insight into the selection of therapy for women with PVs in these genes.

PI_NAMEs: COUCH, FERGUS JOSEPH (contact)

PROJECT_TERMS: Address;Adjuvant;Adjuvant Therapy;African;African American;African American population;African Women;Age;age related;ATM gene;BARD1 gene;Benign;Biological Assay;brca gene;BRCA1 gene;BRCA2 gene;Breast;Breast Cancer Detection;Breast Cancer Patient;Breast Cancer Risk Factor;cancer clinical trial;cancer predisposition;cancer risk;Caring;Categories;CDH1 gene;CHEK2 gene;chemotherapy;Classification;Clinic;Clinical;clinical risk;clinical subtypes;Clinical Trials;clinically relevant;cohort;Colorectal;Contralateral Breast;Data;Disease-Free Survival;DNA;Eligibility Determination;ERBB2 gene;Estrogen receptor positive;Estrogen Receptor Status;Estrogen Receptors;FDA approved;General Population;Genes;Genetic;genetic testing;Germ Lines;Germ-Line Mutation;high risk;high risk population;High Risk Woman;Histologic;Histopathology;hormone therapy;improved;Individual;insight;lifetime risk;Magnetic Resonance Imaging;Malignant Breast Neoplasm;Mammary Neoplasms;Medical Genetics;Methods;Molecular;Mutate;NF1 gene;oncotype;Operative Surgical Procedures;Ovarian;PALB2 gene;Pancreas;Participant;Pathogenicity;population based;predictive marker;Predisposition;Prevention;Progesterone Receptors;Prognosis;Prognostic Factor;Prognostic Marker;Proteins;PTEN gene;Qualifying;RAD51C gene;Recurrence Score;research clinical testing;response;Risk;Risk Assessment;Risk Estimate;Risk Management;risk variant;screening;Screening for cancer;Second Primary Cancers;Selection for Treatments;success;Susceptibility Gene;Test Result;TP53 gene;triple-negative invasive breast carcinoma;tumor;Variant;variant of unknown significance;virulence gene;Woman

PROJECT_TITLE: Project 1


NIH_SPENDING_CATS: Aging;Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Estrogen;Prevention;Women's Health Research

PHR: PROJECT NARRATIVE Premenopausal women diagnosed with ER+/HER2- breast cancer tend to have a more aggressive form of disease compared to women diagnosed in the postmenopausal setting and as such are aggressively treated with chemotherapy, ovarian function suppression and aromatase inhibitors. While this therapeutic strategy improves breast cancer specific outcomes, it is associated with substantial morbidity. This proposal focuses on developing an alternative endocrine approach for premenopausal breast cancer patients using endoxifen without ovarian function suppression and aims to mechanistically understand the basis for endoxifen’s superior anticancer effects.

PROJECT_TERMS: Adjuvant Study;Adjuvant Therapy;anti-cancer;arm;Aromatase Inhibitors;Binding;Biological;Biological Availability;Biopsy;bone;Breast Cancer Cell;Breast Cancer Patient;Breast Cancer therapy;Breast-Conserving Surgery;Cancer Burden;cancer diagnosis;CDK4 gene;Cell Proliferation;Cessation of life;Characteristics;chemotherapy;Clinic;Clinical;Clinical Research;cohort;Cohort Studies;Collaborations;Cyclin D1;Data;Developed Countries;Development;Diabetes Mellitus;Disease;Disease Resistance;Disease-Free Survival;Distant;Dose;Down-Regulation;E2F transcription factors;Early Diagnosis;Endocrine;ERBB2 gene;ESR1 gene;Estrogen receptor positive;Estrogens;Event;Exemestane;Foundations;Genes;Goserelin;Heart Diseases;hormone therapy;Hyperlipidemia;Hypertension;improved;In Vitro;in vivo;Incidence;inhibitor;kinase inhibitor;Laboratories;Malignant Breast Neoplasm;Mammary Neoplasms;Mediating;Menopause;Molecular;Morbidity - disease rate;Mutation;Neoadjuvant Therapy;Newly Diagnosed;North Central Cancer Treatment Group;novel;Oncoproteins;Operative Surgical Procedures;optimal treatments;Oral;Osteoporosis;Outcome;Ovarian;Pathway interactions;Patients;Pharmacodynamics;pharmacologic;Phase;Phase II Clinical Trials;phase II trial;Phosphotransferases;Postmenopause;preclinical study;predictive marker;Predictive Value;Premature Menopause;Premenopause;prevent;primary endpoint;Prognostic Marker;prognostic value;Progression-Free Survivals;prospective;protein expression;Quality of life;Quality of Life Assessment;Randomized;Recommendation;Regimen;Residual Cancers;Resistance;response;Role;secondary endpoint;side effect;Signal Transduction;standard of care;Tamoxifen;Testing;Text;Therapeutic;therapy resistant;Toxic effect;transcriptome sequencing;tumor;Uterus;Woman;women's diagnosis

PROJECT_TITLE: Project 2


ORG_CITY: SCOTTSDALE

ORG_NAME: MAYO CLINIC ARIZONA

ORG_STATE: AZ

PHR: PROJECT NARRATIVE The Mayo Clinic Multiple Myeloma SPORE is a highly productive research program based at the NCI- designated Mayo Clinic Comprehensive Cancer Center located in Minnesota, Florida and Arizona and the Princess Margaret Cancer Centre in Toronto, Ontario. The goal of the SPORE is to support investigators at all three sites with expertise in basic myeloma biology, genetics, clinical research and epidemiology as they work together to translate basic science advances into improved care for myeloma patients. SPORE research projects focus on oncolytic virotherapy, the myeloma tumor microenvironment, myeloma immunotherapy, early detection of myeloma requiring treatment, prevention of myeloma progression, and using genetics to optimize therapy of high-risk myeloma.

PI_NAMEs: BERGSAGEL, PETER LEIF (contact)

PROGRAM_OFFICER_NAME: KUZMIN, IGOR A

PROJECT_TERMS: Advocate;Area;Arizona;Basic Science;Benign;Bioinformatics;Biological Specimen database;Biology;Biometry;Bispecific Antibodies;Cancer Center;Cancer Research Project;career;Caring;Clinic;Clinical;clinical database;clinical epidemiology;Clinical Investigator;Clinical Research;Clinical Trials;Collaborations;Comprehensive Cancer Center;Development;Early Diagnosis;Florida;Foundations;Functional disorder;Funding;Genetic;Goals;high risk;Immune response;immunoregulation;Immunotherapy;improved;Infrastructure;innovation;Institution;Integration Host Factors;International;Joints;Laboratories;Leadership;Malignant - descriptor;Minnesota;Multiple Myeloma;multiple omics;novel;oncolytic virotherapy;Ontario;Patients;Peer Review;Peer Review Grants;Phase I Clinical Trials;Prevention;Productivity;Prognosis;prognostic index;programs;Publications;Regimen;Research;Research Personnel;Research Project Grants;Research Support;Resources;Risk;Site;sound;success;survivorship;Translating;translational cancer research;translational clinical trial;translational scientist;treatment optimization;Tumor Biology;Tumor Markers;tumor microenvironment;tumor-immune system interactions;Vesicular stomatitis Indiana virus;Virotherapy;Work

PROJECT_TITLE: Mayo Clinic Multiple Myeloma SPORE


NIH_SPENDING_CATS: Cancer;Hematology;Rare Diseases

PHR: PROJECT NARRATIVE The Administration Core provides administrative support for all SPORE research activities and assures there is excellent communication between all Mayo sites, all participating investigators and staff, and the NCI. The Administration Core also ensures the patient advocates participation in annual retreats and their inclusion in all key decisions. The Core is a necessary component for a successful SPORE.

PROJECT_TERMS: Achievement;Advisory Committees;Advocate;Arizona;Awareness;career;Clinic;Collaborations;Communication;Communities;design;Detection;Development;Ensure;Florida;Fostering;Funding;Goals;Grant;Growth and Development function;Guidelines;Infrastructure;Leadership;Methods;Multiple Myeloma;Occupational activity of managing finances;operation;organizational structure;Patients;Prevention;Procedures;programs;Reporting;Research;Research Activity;Research Personnel;Research Project Grants;Site;Structure;System;systematic review;Teleconferences;Translational Research;Translations;Work


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Immunization;Prevention;Vaccine Related;Women's Health Research

PHR: NARRATIVE The Core procures biospecimens (snap-frozen, fresh, cryopreserved and FFPE benign and malignant tissues, and whole blood), provides expert histological characterization of both clinically-established and research- based pathologic features, accrues and designs tissue-based benign and breast cancer-associated cohorts, performs high volume assessment of clinical and research-based biomarkers, and employs digital image- based technologies and high-plex quantitative spatial profiling technologies to support breast SPORE projects and other breast cancer translational research projects. These functions are essential for successful translational research, including the projects described in this proposal.

PI_NAMEs: SHERMAN, MARK E (contact)

PROJECT_TERMS: Age;Algorithmic Analysis;Algorithms;Aliquot;Antibodies;Artificial Intelligence;Atypia;Benign;Biological Assay;Biological Markers;Biopsy;Blood;Blood specimen;Breast;Breast biopsy;Breast Diseases;Cancer Burden;candidate marker;CASP3 gene;Classification;CLIA certified;Clinic;Clinical;clinical biomarkers;Clinical Data;Clinical Trials;cohort;Collaborations;Cryopreservation;cryostat;Data Analyses;design;digital;digital applications;digital imaging;digital pathology;Distant Metastasis;epidemiologic data;ERBB2 gene;Evaluation;Evaluation Research;experience;Formalin;Freezing;Gene Mutation;Genetic;Genomic DNA;Germ Lines;high risk;Histologic;Image Analysis;imaging approach;Immune;Immunohistochemistry;Institution;Knowledge;Link;Lobule;MAGEA3 gene;Malignant - descriptor;Malignant Breast Neoplasm;mammaglobin;Mammaplasty;Mammary Gland Parenchyma;Maps;Metastatic Neoplasm to Lymph Nodes;Methods;Mucin 1 protein;nano-string;Neoadjuvant Therapy;Neoplasms;neoplastic;Organoids;Paraffin Embedding;Pathologic;Pathological Staging;Pathology;patient derived xenograft model;Patients;Performance;PKCbeta1;Plasma;predictive marker;Preparation;Process;Prognostic Marker;programmed cell death ligand 1;quality assurance;Registries;Research;Research Design;Research Project Grants;Residual Cancers;Resource Sharing;Resources;response;Risk Factors;Risk Reduction;Sampling;Scanning;Serum;Services;Slide;software systems;Specimen;Stains;survivin;Susceptibility Gene;Technology;Tissue Harvesting;Tissue Microarray;Tissue Sample;Tissues;translational cancer research;Translational Research;translational study;triple-negative invasive breast carcinoma;tumor;Vaccine Antigen;Vaccines;Validation;Whole Blood

PROJECT_TITLE: Biospecimen Core


NIH_SPENDING_CATS: Bioengineering;Breast Cancer;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Data Science;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Women's Health Research

PHR: PROJECT NARRATIVE The Biostatistics, Bioinformatics and Patient Registry Core is comprised of individuals with expertise in biostatistics and/or bioinformatics as well as understanding of factors that impact the development and growth of breast cancer. Their efforts in developing study designs and analysis plans to evaluate the research hypotheses ensures the issue of confounding factors is addressed, reliable and reproducible measurement techniques are employed, emerging scientific insights are incorporated into ongoing studies, and a sufficient number of patients/specimens/mice are utilized to draw conclusions. The care in which studies are designed, conducted, analyzed, and interpreted will impact whether the results are seen as providing insights that should be acted on and further built upon or not.

PI_NAMEs: SUMAN, VERA JEAN  (contact)

PROJECT_TERMS: Address;Archives;B-Cell Antigen Receptor;B-cell receptor repertoire sequencing;Bioinformatics;biomarker identification;Biometry;Breast Cancer Patient;career;Caring;Clinic;Collaborations;Computational Biology;Data;Data Analyses;Data Element;data integration;data management;deep learning;design;Development;digital;digital pathology;Disease;DNA sequencing;Ensure;genome-wide;Genomic approach;Growth and Development function;Histologic;Individual;insight;instrumentation;Knowledge;Machine Learning;machine learning method;Malignant Breast Neoplasm;Manuscripts;Measurement;Medicine;metabolomics;Methodology;Methylation;Monitor;Multiomic Data;Mus;network models;novel;Outcome;patient registry;Patients;phosphoproteomics;programs;Randomized;Reproducibility;Research;Research Design;Research Methodology;Research Personnel;Research Project Grants;Safety;Sample Size;Sampling;Scheme;SNP array;sound;Source;Specimen;study population;T-Lymphocyte;Techniques;Testing;tool;transcriptome sequencing;Work

PROJECT_TITLE: Biostatistic and Patient Registry Core


NIH_SPENDING_CATS: Clinical Research;Genetics;Health Disparities and Racial or Ethnic Minority Health Research;Kidney Disease;Organ Transplantation;Racial and Ethnic Minority Health Research;Transplantation

ORG_CITY: BALTIMORE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: Project Narrative The Maryland “10/14 APOL1 Long-term Kidney Transplantation Outcomes Network (APOLLO) Clinical Center (CC)” will maintain a network of transplant programs and investigators to consent and monitor a cohort of African American (AA) kidney donors and recipients of AA deceased or living donor kidneys, and collect serum and urine for biobanking. This will allow us to prospectively collect long-term follow-up data on all APOLLO participants; provide detailed clinical data and biospecimens on APOLLO participants from our CC; and facilitate return of APOL1 genotype results. The results will help to improve the lives of donors and recipients.

PI_NAMEs: BROMBERG, JONATHAN S (contact);WEIR, MATTHEW R.

PROGRAM_OFFICER_NAME: CHAN, KEVIN E

PROJECT_TERMS: Acceleration;Acute;Address;African American;African ancestry;Albumins;Allografting;American;Antibodies;Apolipoproteins;Bacterial Infections;biobank;Biopsy;Blood;Child;Classification;clinical center;Clinical Data;cohort;Consent;Cost Savings;Counseling;Creatinine;Data;digital pathology;Disparity;DNA;Donor person;Education;Enrollment;Ensure;Environmental Risk Factor;ethnic difference;European;Evaluation;Face;Failure;follow-up;gene interaction;Genes;Genetic;genetic risk factor;Genotype;Geography;graft failure;Graft Survival;Health Care Costs;high risk;HLA Antigens;Hospitals;Immunosuppression;improved;indexing;Individual;Kidney;kidney biopsy;Kidney Failure;Kidney Transplantation;Lesion;Living Donors;living kidney donor;Longterm Follow-up;Maryland;Measures;Medical;Medical center;medical schools;Monitor;novel;Organ;Outcome;Outcome Study;Outcomes Research;Participant;Pattern;Phase;Phenotype;Policies;post-transplant;Prevalence;primary outcome;programs;prospective;Proteinuria;Quality of life;racial difference;recruit;Recurrent disease;Registries;Renal function;Reporting;repository;Research;Research Personnel;Risk;risk variant;Role;Safety;safety assessment;secondary outcome;Serum;Site;Slide;Time;Transplant Recipients;Transplantation;United Network for Organ Sharing;United States National Institutes of Health;Universities;Urine;Variant;Virus Diseases;Washington

PROJECT_TITLE: U Maryland Mid-Atlantic APOLLO Research Network Omic and Clinical Center


PHR: NARRATIVE The Developmental Research Program supports innovative and scientifically meritorious research projects that have the greatest potential to be translated into clinically important applications for the prevention, diagnosis and treatment of women with breast cancer.

PI_NAMEs: HAWSE, JOHN R. (contact)

PROJECT_TERMS: Achievement;Advisory Committees;Advocacy;American Association of Cancer Research;American Cancer Society;anti-cancer research;Applications Grants;Award;Breast;Breast Cancer Patient;Cancer Center;career;Clinic;Clinical;clinical center;Clinical Research;Collaborations;Data;Death Rate;Decision Making;Detection;Development;Diagnosis;Direct Costs;Disabled Persons;Disease;diversity and inclusion;Ensure;Ethnic Population;Evaluation;expectation;experience;Extramural Activities;Foundations;Funding;Future;Generations;Goals;Grant;Human Resources;Incidence;innovation;Institution;interdisciplinary collaboration;Journals;Laboratory Study;Leadership;Letters;Malignant Breast Neoplasm;Manuscripts;Mayo Clinic Cancer Center;meetings;member;Mentors;Minnesota;Minority;Monitor;mortality;originality;Peer Review;Performance;Pilot Projects;Policies;Population Study;Prevention;Procedures;Process;Productivity;Program Research Project Grants;programs;Progress Reports;Publications;Publishing;Qualifying;Quality of life;racial population;recruit;Regenerative Medicine;Research;research and development;Research Personnel;Research Project Grants;Selection Criteria;Site Visit;success;symposium;Testing;Translating;translational potential;Translational Research;translational study;Universities;Utilization Review;Veterans;Woman;women's treatment

PROJECT_TITLE: Development Research Program


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Hematology;Prevention;Rare Diseases

PHR: PROJECT NARRATIVE Effective myeloma research requires blood and tumor tissue connected to patient records for translational research. The Biospecimens, Pathology & Clinical Database Core coordinates all specimen-related research for projects in the Myeloma SPORE. This Core has developed new innovations in natural language processing that will enable investigators to expand myeloma research in the next funding period.

PI_NAMEs: FONSECA, RAFAEL  (contact)

PROJECT_TERMS: Algorithms;Aliquot;archive data;Area;Arizona;base;Bioinformatics;Biological;Biological Specimen database;Biometry;Blood;Blood specimen;Bone Marrow;Bortezomib;Cancer Center;career;Classification;Clinic;Clinical Data;clinical database;clinical practice;Clinical Research;clinical translation;Clinical Trials;Collection;COVID-19 pandemic;Data;data archive;Data Collection;data handling;data harmonization;Data Set;Databases;Dedications;design;Development;Disease;Early Diagnosis;Electronics;Florida;Funding;Geographic Locations;Goals;Grant;high risk;Individual;Information Systems;Infrastructure;innovation;Institution;Institutional Review Boards;K-Series Research Career Programs;Laboratories;Light-Chain Immunoglobulins;Link;Medicine;Metadata;migration;Monoclonal gammopathy of uncertain significance;Multi-Institutional Clinical Trial;Multiple Myeloma;multiple omics;Natural Language Processing;Outcomes Research;Pathogenesis;Pathology;Patient Recruitments;Patients;Performance;peripheral blood;Plasma Cells;Prevention;primary amyloidosis of light chain type;Process;programs;Protocols documentation;Quality Control;Records;Regimen;Research;research and development;Research Personnel;Research Project Grants;Resources;Risk Factors;Safety;Sampling;Services;Specimen;System;therapy outcome;Time;Tissue Banks;Translational Research;translational study;treatment response;Tumor Tissue;user-friendly;Vesicular stomatitis Indiana virus;Virotherapy;Visit;Waldenstrom Macroglobulinemia

PROJECT_TITLE: Biospecimen & Clinical Database Core


PHR: NARRATIVE The Career Enhancement Program is focused on identifying, supporting and mentoring the most highly qualified investigators in basic science, population science and clinical research who have the greatest potential to conduct meaningful translational research in breast cancer and develop independent research programs directed at reducing the burden and mortality from breast cancer.

PROJECT_TERMS: Achievement;Advisory Committees;Advocacy;anti-cancer research;Applications Grants;Award;Basic Science;bench to bedside;Bioinformatics;Biometry;Breast;career;Categories;Clinic;Clinical;Clinical Investigator;Clinical Research;Clinical Sciences;community engaged research;convict;Data;Development;Diagnosis;Direct Costs;Disabled Persons;Discipline;Disease;diversity and inclusion;Ensure;Evaluation;expectation;Extramural Activities;Faculty;Funding;Future;Goals;Grant;health equity;improved;Individual;Laboratories;Leadership;Malignant Breast Neoplasm;Mayo Clinic Cancer Center;Mentors;Minority;Mission;Monitor;mortality;multidisciplinary;next generation;Pathology;patient registry;Policies;Population;Population Sciences;Positioning Attribute;Prevention;Procedures;Process;Productivity;programs;Qualifying;recruit;Reporting;Research;Research Personnel;Research Project Grants;Resources;Science;Scientist;skills;success;Talents;Translational Research;translational scientist;Veterans;Wages;Woman;women with disabilities;women's treatment;Work

PROJECT_TITLE: Career Enhancement Program


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Dementia;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurodegenerative;Neurosciences;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: Early detection of cognitive impairment in primary care settings is a recognized healthcare priority in the United States. To overcome the technical, cultural and logistic barriers of current cognitive screens in primary care settings, we developed the 5-Cog paradigm, which is a brief cognitive assessment paired with a clinical decision-making support that is simple to use, standardized, takes <5 minutes and does not require informants. The proposed study focuses on this low-cost electronic medical record embedded cognitive assessment and decision support that is applicable and appealing for uptake in everyday primary care settings in the United States.

PI_NAMEs: BOUSTANI, MALAZ ;VERGHESE, JOE  (contact)

PROGRAM_OFFICER_NAME: HOMMER, REBECCA EVE

PROJECT_TERMS: active control;Address;Adoption;African American population;Alzheimer's Disease;Alzheimer's disease related dementia;arm;Assessment tool;Black race;Caring;Clinic;Clinic Visits;clinical decision support;clinical decision-making;Clinical effectiveness;clinical efficacy;Cluster randomized trial;Cognitive;cognitive enhancement;cognitive testing;Computerized Medical Record;Consolidated Framework for Implementation Research;cost;Cost Analysis;cost effectiveness;Dementia;dementia care;design;Detection;Diagnosis;Drug Prescriptions;Early Diagnosis;Education;Effectiveness;effectiveness testing;effectiveness/implementation design;effectiveness/implementation study;Elements;experience;follow-up;Funding;Future;health disparity;health disparity populations;Healthcare;Hispanic;Hispanic Populations;Hybrids;Image;Impaired cognition;implementation context;implementation science;improved;Indiana;informant;innovation;Intervention;Laboratories;Logistics;Measures;Methods;Minority;older adult;older patient;Outcome;Paper;participant enrollment;Patient Care;Patients;Population;Pragmatic clinical trial;Primary Care;primary care clinic;Primary Care Physician;primary care setting;primary outcome;Process;Public Health;Qualifying;randomized, clinical trials;Reduce health disparities;Research;Resources;Rural;rural underserved;Sampling;scale up;Science;secondary outcome;Services;Site;socioeconomics;Specialist;Standardization;support tools;symposium;Testing;tool;treatment as usual;trial design;Underserved Population;United States;United States National Institutes of Health;Update;uptake;Urban Population

PROJECT_TITLE: 5-Cog Paradigm to Improve Detection of Cognitive Impairment in Primary Care: Pragmatic Clinical Trial


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Cancer;Clinical Research;Dental, Oral, and Craniofacial Disease;Genetics;HIV/AIDS;Hematology;Infectious Diseases;Lymphatic Research;Lymphoma;Rare Diseases

ORG_CITY: GAINESVILLE

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: NARRATIVE / PUBLIC HEALTH STATEMENT Non-Hodgkin lymphomas remain a common cause of cancer-related death in HIV-infected individuals – highlighting the importance of additional factors such as the opportunistic cancer-causing Epstein-Barr virus (EBV). In this application, we address how EBV rewires cellular DNA replication to facilitate cancer cell proliferation instead of death. We expect our findings to reveal vulnerabilities that may be targeted via novel synthetic lethal approaches to treat EBV-driven HIV/AIDS-lymphomas.

PI_NAMEs: BHADURI-MCINTOSH, SUMITA  (contact)

PROGRAM_OFFICER_NAME: BACCAGLINI, LORENA

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;AIDS-Related Lymphoma;antiretroviral therapy;B-Cell Activation;B-Cell Lymphomas;B-Lymphocytes;Biopsy;Blast Cell;Blood;Burkitt Lymphoma;cancer cell;Cancer Etiology;cancer specimen resource;Cell Cycle;Cell Death;Cell Line;Cell Nucleus;Cell Proliferation;cell transformation;Cells;Cessation of life;chemotherapy;clinically relevant;Complex;Dependence;Development;Disease;DNA;DNA biosynthesis;DNA replication fork;Ensure;Epstein Barr Virus lymphoma cell;Epstein-Barr Virus-Related Lymphoma;Event;experience;gammaherpesvirus;Genes;Genetic;Genome;genome-wide;Goals;helicase;HIV;HIV/AIDS;Human Herpesvirus 4;Immune;Immunocompromised Host;Immunologic Surveillance;immunosuppressed;Impairment;improved outcome;in vivo;Individual;infected B cell;Infection;Influentials;innovation;Investigation;Job's Syndrome;Knowledge;large cell Diffuse non-Hodgkin's lymphoma;Link;lymphoblastoid cell line;Lymphoma;Lymphoma cell;Malignant Neoplasms;Mass Spectrum Analysis;MCM7 gene;Mechanics;Modeling;Morbidity - disease rate;mortality;Mutation;new therapeutic target;Non-Hodgkin's Lymphoma;novel;Nucleotides;Oncoproteins;oral pathogen;Pathway interactions;Patients;Persons;Phase;Predisposition;Proliferating;Property;Proteins;Proteome;Proto-Oncogenes;Public Health;recruit;replication stress;Risk;Role;S phase;STAT3 gene;Stress;Testing;Therapeutic;Tonsil;Trans-Activators;Transcript;transforming virus;Translating;Transplant Recipients;tumor microenvironment;Up-Regulation;Viral;Virus;Virus Latency;Zinc Fingers

PROJECT_TITLE: Exposing synthetic lethal vulnerabilities in EBV-positive AIDS-NHL through novel replication dependency factors

STUDY_SECTION: HCAC

STUDY_SECTION_NAME: HIV Coinfections and HIV Associated Cancers Study Section[HCAC]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Project narrative: Mass drug administration programs in both veterinary medicine and human populations have caused rapid evolution of resistance to all known anthelmintic compounds, including benzimidazoles. Despite the identification of beta-tubulin as one benzimidazole target, we still do not know how it affects parasites and we do not know any beta-tubulin independent benzimidazole resistance mechanisms. We will use massively scaled genetics approaches in both the free-living nematode Caenorhabditis elegans and the parasitic nematode Haemonchus contortus to discover how benzimidazoles kill nematodes and novel mechanisms of resistance.

PI_NAMEs: ANDERSEN, ERIK CHRISTIAN (contact)

PROGRAM_OFFICER_NAME: MO, ANNIE X  Y

PROJECT_TERMS: Affect;Albendazole;Alleles;Anthelmintics;benzimidazole;benzimidazole resistance;beta Tubulin;Biological Assay;Caenorhabditis elegans;Collaborations;Communities;CRISPR/Cas technology;disability-adjusted life years;Drug Design;Drug Targeting;Early Diagnosis;Economic Burden;Enzymes;Evolution;experimental study;extend lifespan;Farm;fitness;fitness test;follow-up;Future;gamma Tubulin;gene discovery;Genes;Genetic;genetic approach;Genetic Crosses;Genome;genome editing;genome-wide;Genomics;Goals;Growth;Haemonchus;Health;Helminths;Hookworms;Human;Knowledge;Laboratories;Measures;Medicine;Modeling;Molecular;Monitor;Morbidity - disease rate;mortality;Nematoda;novel;offspring;Parasite resistance;Parasites;Parasitic nematode;pathogen;Persons;Pharmaceutical Preparations;Phenotype;Phylogenetic Analysis;Poisoning;Population;Predisposition;Production;programs;Proteins;Research;Research Personnel;Resistance;resistance allele;resistance gene;resistance mechanism;Resources;Ruminants;Sampling;Soil;Structural Biologist;success;Testing;Therapeutic;Time;Tissues;Transgenic Animals;Translating;transmission process;Tubulin Interaction;Veterinary Medicine;X Chromosome

PROJECT_TITLE: Discovery of Novel Benzimidazole Resistance Mechanisms

STUDY_SECTION: DDR

STUDY_SECTION_NAME: Drug Discovery and Mechanisms of Antimicrobial Resistance Study Section[DDR]


NIH_SPENDING_CATS: Bioengineering;Cancer;Data Science;Hematology;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Rare Diseases

PHR: PROJECT NARRATIVE The Biostatistics & Bioinformatics Core will provide the SPORE Investigators access to statistical and bioinformatics expertise that includes state-of-the-art statistical analysis; bioinformatics preprocessing, analysis, and interpretation; novel methodology development; and data management resources. It provides a mechanism for consistent and compatible data handling among all projects and ensures analysis across SPORE projects is accomplished in a timely manner. In providing centralized statistical, bioinformatics, and data management support, this Core enables synergies and efficiencies for programmatic initiatives beyond what can be achieved with individual statistical and bioinformatics teams for each project.

PI_NAMEs: GEYER, SUSAN MICHELLE (contact)

PROJECT_TERMS: Address;archive data;Area;Award;Basic Science;Bioinformatics;bioinformatics infrastructure;Biological;Biological Specimen database;Biometry;career development;Cell model;Clinic;Clinical;clinical database;Clinical Management;Clinical Sciences;Clinical Trials;Collaborations;Collection;Common Data Element;Communities;Complement;Complex;computerized data processing;Consultations;Core Facility;Correlative Study;Country;Data;Data Analyses;data archive;Data Collection;Data Element;data handling;data integration;data management;Data Management Resources;data resource;Data Set;data sharing;Data Sources;data standards;Databases;deep learning;design;Development;Ensure;experience;Experimental Designs;Faculty;Funding;Future;Genes;genetic variant;High Performance Computing;high risk;In Vitro;in vivo;Individual;Informatics;informatics infrastructure;Information Management;Infrastructure;innovation;Institution;instrument;K-Series Research Career Programs;Laboratories;Laboratory Study;Machine Learning;Malignant Neoplasms;Mayo Clinic Cancer Center;member;Methodology;Modeling;Monitor;mouse model;multidimensional data;Multiomic Data;Multiple Myeloma;multiple omics;novel;Outcome Measure;Pathway Analysis;Pathway interactions;Patient Care;Patients;Phase;Problem Solving;Procedures;programs;Publications;Quality Control;Research;research and development;Research Design;Research Personnel;research study;Scientist;Security;Source;Specific qualifier value;Specimen;Statistical Data Interpretation;statistics;synergism;System;Techniques;Testing;Time;tool;Translating;Translational Research;tumor registry;web portal;Work

PROJECT_TITLE: Biostatistics & Bioinformatics Core


NIH_SPENDING_CATS: Cancer;Clinical Research;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Genetic Testing;Genetics;Infectious Diseases;Prevention;Primary Health Care;Radiation Oncology;Rare Diseases;Sexually Transmitted Infections

ORG_CITY: TAMPA

ORG_NAME: H. LEE MOFFITT CANCER CTR & RES INST

PHR: NARRATIVE Oropharyngeal cancer (OPC) incidence is significantly increasing with most cases (~80%) caused by human papillomavirus (HPV) infection type 16. Our goal is to validate a non-invasive diagnostic biomarker panel that we have developed to detect OPC early. We hypothesize that we can distinguish early OPC cases from cancer- free individuals using biomarkers related to HPV and host epigenetic alterations, thereby identifying tumors that can be effectively and safely treated with a single modality where survival is highest.

PI_NAMEs: AMELIO, ANTONIO LUIGI;GIULIANO, ANNA R. (contact)

PROGRAM_OFFICER_NAME: CHEN, ZHONG

PROJECT_TERMS: Address;Age;Awareness;biobank;Biological Assay;Biological Markers;Biological Specimen Banks;biomarker development;biomarker panel;Breast Cancer Detection;Cancer Burden;Cancer Center;Cancer Detection;cancer diagnosis;Cancer Patient;case control;Cervical Cancer Screening;chemoradiation;Clinical;clinical assay development;Collaborations;colorectal cancer screening;Data;data repository;Dental General Practice;design;Detection;Development;Diagnosis;Disease;DNA;Early Detection Research Network;Early Diagnosis;early screening;Epidemiologist;Epidemiology;Epigenetic Process;Ethnic Origin;Evaluation;experience;Follow-Up Studies;Genes;genome wide methylation;Goals;high risk population;HPV oropharyngeal cancer;HPV screening;Human papilloma virus infection;Human Papilloma Virus Vaccination;Human Papillomavirus;Human papillomavirus 16;improved;improved outcome;Incidence;Individual;Infrastructure;innovation;Ipsilateral;Laboratories;Lesion;Lifelong disability;Literature;Malignant Neoplasms;malignant oropharynx neoplasm;Measures;Medical;Medical center;Medical Oncologist;men;Methods;Methylation;Modality;Morbidity - disease rate;mortality;Mouth Neoplasms;neoplastic;noninvasive diagnosis;Oral;Oral health;oral HPV;Oropharyngeal;Patient-Focused Outcomes;Performance;Phase;Positive Lymph Node;Prevention;Prevention approach;Primary Prevention;prospective;Race;Radiation Oncologist;Research;Research Infrastructure;Resources;Sampling;screening;Screening for cancer;Secondary Prevention;Sensitivity and Specificity;Series;sex;Site;Specimen;success;Tobacco;Tobacco use;tumor;Tumor Tissue;Tumor-Derived;Universities;Validation;Viral

PROJECT_TITLE: Biomarker Approach to Screening for the early detection of HPV-related Oropharyngeal Cancer (BASH OPC)


ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative - Overall The Michigan Center for Diabetes Translational Research (MCDTR) has a strong track record of strengthening its members' capacities to design and test in real-life settings innovative evidence-based approaches to prevent and manage diabetes. We will build on this work by mobilizing multidisciplinary expertise and resources on the most effective, innovative, and scalable strategies to develop and evaluate interventions and polices involving multiple sectors to address unmet socio-economic needs, provide ongoing support for healthy behaviors, and improve cross-sectoral care and service delivery to improve health equity and outcomes among people at risk for and with diabetes. The MCDTR will reach out to and engage investigators and practitioners in relevant fields, with a particular emphasis on junior investigators and those from underrepresented groups. We will provide multidisciplinary individual and group consultations, trainings, and workshops; provide Pilot and Feasibility funding and mentorship; and conduct enrichment activities to catalyze and sustain effective cross- disciplinary and cross-sectoral collaborations to improve health equity and outcomes.

PI_NAMEs: HEISLER, MARY ELLEN MICHELE (contact);PIATT, GRETCHEN A

PROGRAM_OFFICER_NAME: ARTIS DICKERSON, SHAVON

PROJECT_TERMS: Address;Affect;Air;Area;Awareness;base;Behavior;Behavioral;Black race;burden of illness;Cardiometabolic Disease;care delivery;Caring;Clinical;Collaborations;Collection;Communication;Communities;Community Healthcare;community organizations;Complications of Diabetes Mellitus;Consult;Consultations;COVID-19 mortality;Data;data acquisition;design;Development;diabetes management;Diabetes Mellitus;Diabetes prevention;diabetes risk;Discipline;Dissemination and Implementation;economic disparity;economic need;Economics;Education;Educational Status;Educational workshop;effective intervention;Effectiveness;Environment;Equity;Evaluation;evidence base;experience;Exposure to;Face;family support;Feasibility Studies;Federally Qualified Health Center;food insecurity;Fostering;Funding;Geographic Locations;Geography;Goals;Grant;Health;health care quality;health care service organization;health determinants;health difference;health disparity;health equity;Health equity research;Health Services;Health system;housing instability;Improve Access;improved;Incidence;Individual;Inequity;innovation;interest;International;Intervention;intervention delivery;Latino;Laws;Lesbian Gay Bisexual Transgender Queer;Life;Low income;low socioeconomic status;Measurement;Measures;member;Mentorship;Methods;Michigan;multidisciplinary;Native Americans;Neighborhoods;North Carolina;novel;novel strategies;Obesity;online resource;Outcome;outreach;peer support;Persons;Pilot Projects;Police;Policies;Population;population health;Populations at Risk;Prevalence;prevent;Prevention;programs;protocol development;Public Health;Race;Research;Research Design;Research Personnel;research study;Research Support;Resources;Risk;SARS-CoV-2 infection;Self Management;service delivery;service organization;Services;Shapes;social;Social Class;social disparities;Social Work;socioeconomics;Statistical Data Interpretation;Technology;Telephone;Testing;therapy design;Time;Toxin;Training;Translational Research;Translations;Underrepresented Populations;United States;United States National Institutes of Health;Universities;Water;web site;web-based tool;Work


NIH_SPENDING_CATS: Diabetes

PI_NAMEs: HEISLER, MARY ELLEN MICHELE (contact)

PROJECT_TERMS: Address;Affect;Awareness;Behavioral;Caring;Collaborations;Communities;community setting;Data;design;Development;Diabetes Mellitus;Diabetes prevention;diabetes risk;diversity and inclusion;effective intervention;Elements;Environment;Equity;Evaluation;evidence base;Evidence based intervention;experience;family support;Feasibility Studies;follow-up;Fostering;Funding;Goals;Grant;Health;health care service organization;health determinants;health equity;Health equity research;Health system;Improve Access;improved;Infrastructure;interest;International;Intervention;Leadership;member;Methods;Michigan;Monitor;multimodality;National Institute of Diabetes and Digestive and Kidney Diseases;novel strategies;Outcome;peer support;Personal Satisfaction;Persons;Pilot Projects;Policies;Population;prevent;Process;programs;Research;Research Methodology;Research Personnel;Research Support;Resources;Self Management;Services;social;success;Training;Training and Education;Translational Research;translational scientist;United States National Institutes of Health;web site;Work

PROJECT_TITLE: Administration Core


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Cost Effectiveness Research;Diabetes;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Networking and Information Technology R&D (NITRD);Prevention;Telehealth

PI_NAMEs: HAYWARD, RODNEY A. (contact)

PROJECT_TERMS: Address;administrative database;Adopted;Attitude;barrier to care;Behavior;Behavioral;Belief;Biometry;Caring;Clinic Visits;Clinical;clinical database;Collaborations;Collection;Communication;Communities;community intervention;comorbidity;Complex;Consult;Consultations;Cost Analysis;cost effectiveness;culturally appropriate intervention;Data;data acquisition;data management;Development;diabetes control;diabetes management;Diabetes Mellitus;disease model;Dissemination and Implementation;dissemination science;Economic Models;Educational workshop;Effectiveness;eHealth;Epidemiologic Methods;Equity;Evaluation;examination questions;experience;Faculty;family support;functional status;Funding;handheld mobile device;Health;health determinants;health disparity;health equity;health related quality of life;Health system;Human Resources;implementation science;improved;innovation;interdisciplinary approach;Intervention;Measurement;Measures;member;Metabolic Diseases;Methods;mHealth;Michigan;Mission;Modeling;Obesity;Observational Study;outreach;Patient Outcomes Assessments;peer support;Performance;Population;Populations at Risk;Prevention;protocol development;Psychometrics;Public Health Informatics;Quasi-experiment;Research;Research Design;Research Personnel;research study;Resources;response;Science;Self Management;simulation;skills;social;Statistical Data Interpretation;Survey Methodology;synergism;Technology;Telephone;telephone based;therapy design;translational pipeline;Translational Research;web-based tool;Work

PROJECT_TITLE: Evaluation Methods and Intervention Strategies Core