ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cardiovascular;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Mental Health;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: BOSTON

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

ORG_STATE: MA

PHR: PROJECT NARRATIVE Although Black Americans are twice as likely to have Alzheimer’s disease than White Americans, little is known about the impact of social and societal determinants of health on neurocognitive integrity of the medial temporal hippocampal memory and prefrontal-executive systems, the primary brain systems impacted in Alzheimer’s disease. The objective of this application is to investigate the impact of interpersonal and institutional/structural racism on neurocognitive integrity of these brain systems in Black adults aged 65 years and older and to examine cardiovascular disease risk as an underlying biological mechanism. Addressing this knowledge gap is critical for developing new health policies and biobehavioral and social interventions for healthy aging.

PI_NAMEs: SCHON, KARIN  (contact)

PROGRAM_OFFICER_NAME: FRANKOWSKI, DAVID WITT

PROJECT_TERMS: Address;Adult;African American population;Age;Aging;aging brain;Algorithms;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Ambulatory Blood Pressure Monitoring;Ambulatory Monitoring;American;American Heart Association;Amygdaloid structure;Atherosclerosis;biobehavior;Biological;Biological Markers;Biometry;Black American;Black race;black women;Blood Pressure;Blood Tests;Brain;brain health;Cardiology;cardiovascular disorder risk;cardiovascular health;caucasian American;Chronic;Chronic stress;Cognitive;cognitive neuroscience;cognitive testing;college;community engagement;comorbidity;Data;depressive symptoms;Dimensions;Discrimination;Disparity;Education;Episodic memory;Equation;executive function;Exhibits;experience;Family;Family history of;Fasting;Future;Genetic Risk;geriatric mental health;Goals;Head;Health;health determinants;health disparity;health inequalities;Health Policy;healthy aging;Hippocampus;Human;human old age (65+);Hypersensitivity skin testing;Implicit Association Test;indexing;Inequity;Institution;Institutional Racism;Interview;Knowledge;Left;Life Stress;Link;Lipids;Magnetic Resonance Imaging;Measures;Medial;Mediating;Mediation;Mediator;Memory;Memory Loss;Mental Depression;Mental Health;Methods;Modeling;Nerve Degeneration;neural;Neurobiology;Neurocognitive;neuropathology;Neuropsychology;older adult;Outcome;Participant;perceived discrimination;physical conditioning;Population Heterogeneity;Positioning Attribute;predictive modeling;Prefrontal Cortex;Proxy;Race;racism;Recording of previous events;recruit;residential segregation;Risk Factors;sex;social;Social Discrimination;social factors;social interventions;social stress;Societal Factors;Socioeconomic Status;Source;Structural Racism;Structure;System;Testing;Thick;White Matter Hyperintensity

PROJECT_TITLE: Perceived racism, cardiovascular disease risk, and neurocognitive aging

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


ADMINISTERING_IC: AI

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Genetics;Health Disparities and Racial or Ethnic Minority Health Research;Hematology;Human Genome;Infectious Diseases;Racial and Ethnic Minority Health Research;Rare Diseases;Sepsis

ORG_CITY: BALTIMORE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: Project Narrative To explain the enigmatic endemicity of typhoid fever in the small Pacific island nation of Samoa since at least the 1960s, despite steady improvements in water and sanitation, we hypothesize that a unique strain of S. Typhi entered Samoa decades ago and expanded into the dominant circulating strain, and asymptomatic chronic gallbladder carriers of the strain serve as an effective long-term reservoir and source of infection. Through our close collaboration with the Samoa Ministry of Health, the “Samoa Typhoid Fever Surveillance Initiative,” we propose a series of comparative genomic and geospatial analyses integrating whole genome sequence data of Salmonella Typhi isolates from Samoa with clinical and household epidemiologic data to determine the population structure, evolutionary origins, and local patterns of transmission including the relative role of asymptomatic chronic carriers of Salmonella Typhi. Where previous large scale phylogenetic studies of Salmonella Typhi have demonstrated the feasibility and public health utility of our experimental approaches, none have focused on Samoa nor been implemented as part of an accelerated and coordinated national typhoid control program; therefore, our results will not only contribute a Polynesian perspective to the field of Salmonella Typhi genomics, but also present new information on endemic typhoid fever to assist the Samoa Ministry of Health and our international collaborators in public health decisions.

PI_NAMEs: SIKORSKI, MICHAEL JOSEPH (contact)

PROGRAM_OFFICER_NAME: ALEXANDER, WILLIAM A

PROJECT_TERMS: Acceleration;Acute;Age;Age Years;Antibiotic Resistance;Bacteremia;Bacteria;bacterial genome sequencing;Bacterial Infections;Bile fluid;Biliary;Blood;Blood Circulation;Bone Marrow;chlorination;Cholelithiasis;Chronic;Cities;Clinical;Collaborations;Collection;Communicable Diseases;Comparative Genomic Analysis;comparative genomics;Consumption;contaminated water;Country;Data;Disease;disease model;Disease Outbreaks;Duodenum;Environment;Environmental Risk Factor;epidemiologic data;Epidemiology;Etiology;Evolution;Exhibits;extensive drug resistance;Family member;Female;Filtration;Flushing;food consumption;Food Contamination;Fostering;Founder Effect;Funding;Gallbladder;Gene Deletion;Genes;Genome;genome sequencing;genomic epidemiology;Genomic Segment;Genomics;Genotype;Geography;Goals;Health;Hepatobiliary;Household;Human;improved;Incidence;Incubated;Individual;Infection;International;Intestinal Mucosa;Intestines;Investigation;Island;Link;Liquid substance;Liver;lymphatic drainage;Macrophage;Methods;Modeling;Modernization;Molecular;Mononuclear;Obesity;Pacific Islands;Pattern;Persons;Phagocytes;Phylogenetic Analysis;Phylogeny;Policies;Polynesian;Population;Predisposition;Prevalence;programs;Public Health;Recording of previous events;Relapse;resistance factors;Resolution;Risk;Risk Factors;Role;Salmonella typhi;Samoa;Samoan;Sanitation;Seasons;Sepsis;septic;Series;Silicon Dioxide;Single Nucleotide Polymorphism;Source;spatiotemporal;Spleen;Structure;System;Systemic infection;Technology;Testing;Time;tool;Training;transmission process;Trees;Typhoid Fever;Variant;Virulence Factors;Water;water quality;Water Supply;waterborne;whole genome

PROJECT_TITLE: Genomics of Salmonella Typhi in Samoa: Population structure and genomic epidemiology

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F13-Z(20)L]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Natural Products

ORG_CITY: HOUSTON

ORG_DEPT: CHEMISTRY

ORG_NAME: RICE UNIVERSITY

ORG_STATE: TX

PHR: PROJECT NARRATIVE  Transformations that allow for the rapid introduction of complexity have become increasingly important in the areas of drug discovery, agriculture, and materials science. The objective of this proposal is to develop new methods and strategies to convert aromatic compounds into complex small molecules that are highly desirable but not readily accessible. The proposed research will simplify and expand synthetic pathways to molecular motifs that are prevalent in bioactive natural products and pharmaceuticals.

PI_NAMEs: SARLAH, DAVID  (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TITLE: Dearomative Functionalization with Arenophiles

STUDY_SECTION: SBCA

STUDY_SECTION_NAME: Synthetic and Biological Chemistry A Study Section[SBCA]


NIH_SPENDING_CATS: Congenital Structural Anomalies;Kidney Disease;Pediatric;Polycystic Kidney Disease

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Epithelial cell function is crucial for the human body. Many diseases such as metastatic cancer manifest through aberrant surface delivery of proteins in epithelial cells or overgrowth of epithelial tissues. The proposed research will provide insights into fundamental regulatory processes that govern epithelial polarity, which is necessary to enable development of novel strategies to treat or to prevent human diseases.

PI_NAMEs: FOLSCH, HEIKE  (contact)

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TERMS: Apical;Area;basolateral membrane;Biochemistry;Biological;Cell Adhesion Molecules;Cell membrane;cell motility;Cell Physiology;Cell Polarity;Cells;Chronic;Clathrin Adaptors;Complement;Complex;Crohn's disease;Development;Disease;Disseminated Malignant Neoplasm;Elements;Endosomes;Epithelial Cells;Epithelium;experimental study;Focal Adhesions;Growth;Growth Hormone Receptor;Health;Homeostasis;Human;Human body;human disease;Imaging Techniques;Inflammation;innovation;insight;Lipids;Maintenance;Malignant Neoplasms;Mass Spectrum Analysis;Membrane;migration;monolayer;novel;novel strategies;Nutrient;Organ;Organizational Change;phosphoinositide-3,4,5-triphosphate;Phosphotransferases;photoactivation;Play;Polycystic Kidney Diseases;prevent;Process;Proteins;receptor;Receptor Signaling;recruit;Recycling;Research;Role;Sorting;Speed;Surface;Testing;Tissues;TLR3 gene;Total Internal Reflection Fluorescent;trafficking;uptake;Vesicle;Waste Products;Work;wound

PROJECT_TITLE: Role of Membrane Trafficking in Epithelial Homeostasis


ADMINISTERING_IC: CA

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: American Indian or Alaska Native;Cancer;Clinical Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: OKLAHOMA CITY

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PHR: PROJECT NARRATIVE Much of the extreme Native American cancer disparities are due to cancer types where early screening and access to healthcare have the largest impact, suggesting that these disparities could be mitigated with a stronger Native American healthcare workforce and infrastructure, and yet, the most underrepresented population in science and medicine are Native Americans. In response, we provide an intensive 8 week summer course that serves as a primer for cancer research, along with curriculum development and outreach activities that will directly impact >76 participants, annually, and indirectly impact thousands of underserved students, teachers, families and community members, over five years.

PI_NAMEs: RAMESH, RAJAGOPAL  (contact);SMITH, KENT

PROGRAM_OFFICER_NAME: CALZOLA, JESSICA MARIE

PROJECT_TERMS: Advisory Committees;Agreement;American Indians;anti-cancer research;Biomedical Research;Cancer Center;cancer education;cancer health disparity;cancer prevention;cancer type;career;Chairperson;Cherokee Nation;cohort;college;Comanche;Communities;Community Health;Community Outreach;cost;curriculum development;Death Rate;Development;Disparity;Early Diagnosis;early screening;Education;Education and Outreach;Educational Curriculum;Educational Materials;Educational process of instructing;Enrollment;Event;experience;Eye;faculty mentor;Family;Fostering;Funding;Future;General Population;hands on research;health care availability;health disparity;Health Sciences;Health Status;Health system;Healthcare;high school;High School Faculty;High School Student;higher education;Hour;Human Resources;Infrastructure;Institution;interest;intertribal;junior high school;Kiowa;Laboratory Research;Malignant Neoplasms;matriculation;Medical Students;Medicine;member;Mentors;Mentorship;Middle School Faculty;Middle School Student;mortality;Native American population;Native Americans;Oklahoma;Osteopathic Medicine;outreach;Participant;Pathway interactions;Patients;Population;Prevention education;programs;Public Health;recruit;Research;research and development;Research Training;response;Role;Rural;Schools;Science;screening;Screening for cancer;STEM field;STEM program;student participation;Students;summer program;teacher;Training;Training Programs;tribal community;tribal health;Tribes;undergraduate student;Underrepresented Populations;underserved students;United States National Institutes of Health;Universities;Wichita;Youth

PROJECT_TITLE: Native American Youths Enjoy Science - YES Oklahoma

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


ORG_CITY: SAN ANTONIO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

PHR: NARRATIVE Mg2+ is essential for wide range of cellular processes including the imposition of membrane shape and stability, neutralization and stabilization of nucleic acids and nucleotides, channel modulation, enzyme secretion from acinar cells, and serves as a cofactor for cytosolic and mitochondrial metabolic enzymes. Although cellular Mg2+ dynamics is accomplished via numerous Mg2+ transport machineries, the molecular identity of these Mg2+ flux mechanisms have not been fully elucidated. In the MIRA program, we will identify ligands and channels and elucidate Mg2+-dependent metabolic signals that would establish the Mg2+ flux compendium.

PI_NAMEs: MUNISWAMY, MADESH  (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TERMS: Ablation;Acinar Cell;Agonist;Binding;Biochemical Reaction;Bioenergetics;Biological;Buffers;Calcium;Cardiac Myocytes;Cations;Cell Death;Cell membrane;Cell model;Cell Physiology;Cells;Cellular biology;cofactor;Complex;CRISPR/Cas technology;Cysteine;Cytosol;Deficiency Diseases;defined contribution;Dissociation;Endosomes;Enzymes;Equilibrium;Event;Functional disorder;Funding;Future;gain of function;Homeostasis;Hormonal;ID2 gene;Ion Channel;ionization;Isomerase;Isomerism;Knock-in;Laboratories;Ligands;Link;Lysosomes;Magnesium;Mediating;Membrane;Metabolic;Metabolism;MgATP;Mitochondria;mitochondrial dysfunction;Mitochondrial Matrix;mitochondrial permeability transition pore;Molecular;mouse model;mutant;National Institute of General Medical Sciences;Necrosis;Nucleic Acids;Nucleotides;Organelles;Oxidation-Reduction;Phenotype;Physiological;prevent;programs;Proteins;Quality Control;Rest;RNA interference screen;Role;Route;Shapes;Signal Pathway;Signal Transduction;Stimulus;Stress;Testing;Variant;Work

PROJECT_TITLE: Magnesium flux compendium: Discover ligands, channels, and metabolic signals


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Biotechnology;Neurosciences

ORG_CITY: ITHACA

ORG_DEPT: MISCELLANEOUS

ORG_NAME: CORNELL UNIVERSITY

ORG_STATE: NY

PHR: Project Narrative Phosphatidic acid is a lipid signaling molecule whose aberrant production or accumulation can lead to many diseases, including several types of cancer, neurodegeneration, and susceptibility to infection. This proposal seeks to develop and apply cutting-edge toolsets to understand how cells regulate the production and metabolism of phosphatidic acid to maintain physiological processes that depend on it without tipping the balance away from homeostasis to favor pathological outcomes.

PI_NAMEs: BASKIN, JEREMY  (contact)

PROGRAM_OFFICER_NAME: NIE, ZHONGZHEN

PROJECT_TITLE: Deciphering phosphatidic acid homeostasis and signaling using optogenetic membrane editors (Equipment Supplement 2024)

STUDY_SECTION_NAME: Cell Structure and Function 1 Study Section[CSF1]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Chronic Obstructive Pulmonary Disease;Genetics;Human Genome;Infant Mortality;Lung;Neonatal Respiratory Distress;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: PROJECT NARRATIVE:  Chemical changes to our genetic information that do not change the underlying DNA sequence itself are referred to as “epigenetic” changes, and are increasingly being recognized to be altered in a wide range of lung diseases. How these epigenetic alterations contribute to the onset or progression of these diseases, and whether we can modify the epigenome to treat lung diseases remains largely unknown. This proposal will define how the SWI/SNF complex establishes patterns of chromatin accessibility (a type of epigenetic change) during development of the lung epithelium, and how these same patterns are modified by the SWI/SNF complex following repair after lung injury in the adult.

PI_NAMEs: SINNER, DEBORA ;ZACHARIAS, WILLIAM JOHN (contact)

PROGRAM_OFFICER_NAME: LIN, SARA

PROJECT_TERMS: Adult;Alveolar;Alveolar Cell;alveolar epithelium;ARID1A gene;Bronchopulmonary Dysplasia;Cell division;cell type;Chemicals;Chromatin;Chromatin Modeling;chromatin remodeling;Chronic Obstructive Pulmonary Disease;Code;Data;Development;Disease;Disease Progression;DNA Sequence;Drosophila snf protein;Epigenetic Process;epigenetic regulation;epigenome;epigenomics;Epithelial Cells;epithelial repair;epithelial stem cell;Epithelium;Foundations;Future;Gene Expression;genetic information;Human;Impairment;influenza infection;Lung;lung development;Lung Diseases;lung injury;Mediating;Mediator;Mus;Neonatal Mortality;Pathogenesis;Pattern;Play;Process;programs;pulmonary function;repaired;Respiratory distress;response;Role;stem cell genes;stem cell population;Structure;SWI/SNF Family Complex;Systems Biology;Therapeutic;Time;tool;transcription factor;translational study

PROJECT_TITLE: Epigenetic Regulation of the Maturation and Function of Lung Epithelium by the SWI/SNF Proteins ARID1A and ARID1B.


NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: BIRMINGHAM

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: NARRATIVE: We will purchase a newly available piece of equipment, PippinHT, to more efficiently prepare size- selected cDNA libraries that will allow us to advance the specific aims of the parental R01, 5R01GM146756.

PI_NAMEs: DUTTA, ANINDYA  (contact)

PROGRAM_OFFICER_NAME: CZAPLINSKI, KEVIN

PROJECT_TERMS: Affect;cDNA Library;Cell Line;Complementary DNA;Complex;Equipment;Family;Funding;Gatekeeping;Gene Expression;gene repression;Genes;Length;Libraries;MicroRNAs;Modification;novel;Phenotype;Regulation;Repression;RNA;RNA-Induced Silencing Complex;Testing;transcriptome sequencing

PROJECT_TITLE: Involvement of Noncanonical Short RNAs in Gene Repression through the RNA-Induced-Silencing Complex

STUDY_SECTION: MG

STUDY_SECTION_NAME: Molecular Genetics Study Section[MG]


ORG_CITY: CAMBRIDGE

ORG_NAME: HARVARD UNIVERSITY

PHR: Project Narrative Chemical genetics is powerfully enabling for biological discovery and therapeutics development. We propose to leverage breakthroughs in precision genome-editing technologies and multi-omics to transform chemical genetic approaches, allowing us to illuminate small molecule mechanism and endogenous protein structure-function at scale and in high resolution. By applying these innovative approaches to critical and diverse protein targets, we expect to advance our fundamental understanding of drug mechanism of action and protein complex structure and function.

PI_NAMEs: LIAU, BRIAN  (contact)

PROGRAM_OFFICER_NAME: ASLAN, KADIR

PROJECT_TERMS: Address;Alleles;Allosteric Regulation;Androgen Receptor;Binding;Biological;Biology;Cells;Cellular biology;chemical genetics;Chemicals;Clustered Regularly Interspaced Short Palindromic Repeats;Computational Biology;Development;Disease;drug mechanism;Drug Targeting;Environment;Future;genetic approach;Genetic Screening;genome editing;genomic platform;Genomics;In Situ;innovation;Malignant Neoplasms;Molecular Biology;Molecular Mechanisms of Action;multicatalytic endopeptidase complex;multiple omics;mutant;Mutation;mutation screening;new technology;Oncogenes;Pathway interactions;Phenotype;protein complex;Protein Complex Subunit;protein degradation;protein structure function;Proteins;Research;Resolution;Signal Transduction;small molecule;structural biology;Structure;System;Technology;Testing;therapeutic development;tool;transcription factor;Ubiquitin;Work

PROJECT_TITLE: Integrating Chemical Genetic Approaches with Precision Genome Editing


ED_INST_TYPE: SCHOOLS OF PHARMACY

ORG_CITY: CHAPEL HILL

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Narrative Protein allostery is a fundamental phenomenon in which ligand binding at one site affects substrate activity or ligand binding at a second, distal site of the protein. Allostery is a primary mode of regulation for enzymes and other proteins that drive signal transduction and metabolism, and it is now being used in some drug development efforts, even though the mechanisms of allostery are not well understood. The work in this project will characterize dynamics and allosteric communication pathways for the homodimeric enzymes chorismate mutase and thymidylate synthase, and for engineered optogenetic conformational switch proteins.

PI_NAMEs: LEE, ANDREW L (contact)

PROGRAM_OFFICER_NAME: CHO, THOMAS Y

PROJECT_TERMS: Address;Affect;Allosteric Regulation;Antineoplastic Agents;Area;Attention;base;Behavior;Binding Sites;Biochemistry;Biology;biophysical analysis;biophysical techniques;Calorimetry;Catalysis;chemical conjugate;Chemistry;Chorismate Mutase;Communication;dimer;Distal;drug development;drug discovery;Engineering;Enzymes;Escherichia coli;Exhibits;falls;flexibility;Fluorouracil;Foundations;Goals;Guanosine Triphosphate Phosphohydrolases;Human;improved;interest;Investigation;Label;Laboratories;Ligand Binding;Ligands;Metabolism;Molecular Conformation;molecular dynamics;Movement;Nature;NMR Spectroscopy;optogenetics;Pathway interactions;Property;Protein Engineering;protein function;Proteins;Protomer;Regulation;Relaxation;Role;Signal Transduction;Signaling Protein;Site;small molecule;Structure;System;Technology;Thymidylate Synthase;Work;X-Ray Crystallography;Yeasts

PROJECT_TITLE: Mechanisms and dynamics of allosteric function in proteins

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Chronic Pain;Interstitial Cystitis;Pain Research;Urologic Diseases

ORG_CITY: MILWAUKEE

ORG_DEPT: PHYSIOLOGY

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: Interstitial cystitis/bladder pain syndrome (IC/BPS) affects millions of Americans, and current treatment options are ineffective for many patients. This project aims to determine the role of angiotensin signaling in developing and maintaining disease symptoms of IC/BPS using animal models. These results could open up new FDA- approved treatments with widely available and safe angiotensin inhibitors, substantially impacting patients’ quality of life.

PI_NAMEs: MICKLE, AARON DAVID (contact)

PROGRAM_OFFICER_NAME: MULLINS, CHRISTOPHER V

PROJECT_TERMS: Affect;Afferent Neurons;American;Angiotensin II;Angiotensins;Animal Disease Models;Animal Model;Behavior;biological adaptation to stress;Bladder;Bladder Diseases;Bladder Dysfunction;Body System;Cardiac;cell type;chronic painful condition;chronic pelvic pain;coronary fibrosis;cytokine;Disease;disease model;Event;FDA approved;Fibrosis;Foundations;Frequencies;Functional disorder;Hormones;Human;improved;Infiltration;Inflammation;Inflammation Mediators;Inflammatory;inhibitor;Interstitial Cystitis;Kidney;Link;Literature;Liver;Lung;Macrophage;mast cell;Measures;Modeling;Molecular;mouse model;Myofibroblast;Nociception;Nocturia;oxidative damage;Oxidative Stress;Pathology;Patients;Peptide Signal Sequences;Peptides;Peripheral;pharmacologic;Play;Production;Quality of life;Rattus;Receptor Activation;receptor expression;Receptor Signaling;Receptor, Angiotensin, Type 1;reduce symptoms;Renin;Research;Research Project Grants;Role;Sensory;Shapes;side effect;Signal Pathway;Signal Transduction;Source;Symptoms;Testing;Tissue Model;Tissues;Transgenic Organisms;Type 2 Angiotensin II Receptor;United States;vasoconstriction;Water;Woman

PROJECT_TITLE: Role of Angiotensin II in Bladder Dysfunction

STUDY_SECTION: KUFD

STUDY_SECTION_NAME: Kidney and Urological Systems Function and Dysfunction Study Section[KUFD]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Autoimmune Disease;Diabetes;Eye Disease and Disorders of Vision;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: GALVESTON

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

PHR: NARRATIVE Mechanisms of RGC and axonal degeneration in diabetic retinopathy (DR) is largely unknown. Our proposed studies will identify novel roles of Sirt6 and DDR-ATM pathway in retinal neurodegeneration in DR and establish a link between them. Knowledge learned from this project may identify novel strategies to limit RGC and axonal injury and preserve vision in DR.

PI_NAMEs: ZHANG, WENBO  (contact)

PROGRAM_OFFICER_NAME: SHEN, GRACE L

PROJECT_TERMS: Abbreviations;Adult;Age;age acceleration;age related;Aging;aging mechanism;aging process;Animal Model;anti aging;ataxia telangiectasia mutated protein;ATM Signaling Pathway;Axon;axon injury;axonal degeneration;beta-Galactosidase;Biochemistry;Blindness;blood glucose regulation;Blood Vessels;Brain;Cardiovascular system;Cell Aging;Cell Death;Cell division;cell injury;cell type;Cessation of life;Chronic;Clinic;Clinical;clinically significant;conditional knockout;Data;Deacetylase;Diabetes Mellitus;diabetic;Diabetic Retinopathy;Disease;DNA Damage;DNA Repair;Electroretinography;Endothelial Cells;Exhibits;Extravasation;Family;Functional disorder;Gamma-H2AX;Ganglion Cell Layer;gene repression;Genes;Genomic Instability;Glucose;Histone Deacetylase;Histone H3;Homologous Gene;Immunohistochemistry;Inflammation;Injury;Inner Nuclear Layer;Kidney;knock-down;Knock-out;Knowledge;Learning;life span;Link;Lysine;Mammals;Mediating;member;Microvascular Dysfunction;Mitochondria;mitochondrial dysfunction;Modeling;mouse model;Mus;neovascularization;Nerve Degeneration;Neuronal Injury;Neurons;neuroprotection;Nicotinamide adenine dinucleotide;nitrosative stress;non-invasive imaging;novel;novel strategies;Nuclear;Optic Nerve;Optical Coherence Tomography;overexpression;Oxidative Stress;Pathologic;pathological aging;Pathology;Pathway interactions;Patients;Phenotype;Play;Positioning Attribute;premature;Premature aging syndrome;preservation;prevent;Process;Proteins;Reperfusion Therapy;Reporting;response;Retina;retinal ganglion cell degeneration;Retinal Ganglion Cells;retinal ischemia;retinal neuron;Role;senescence;senescence associated secretory phenotype;senescent cell;Sirtuins;Stains;Stimulus;Streptozocin;Stress;Synapsins;Testing;transcription factor;Vision;Visual evoked cortical potential;Visual impairment;Yeasts

PROJECT_TITLE: Anti-Aging Molecule Sirt6 in Neuroprotection in Diabetic Retina


ADMINISTERING_IC: EB

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_DEPT: ENGINEERING (ALL TYPES)

PHR: Project Narrative Non-invasive optical imaging is essential for understanding biological functions at the cellular or sub- cellular level. This project brings together an interdisciplinary team to develop the next generation microscopy techniques for imaging deep and fast within intact tissues and organs.

PI_NAMEs: NISHIMURA, NOZOMI ;WISE, FRANK W;XU, CHRIS  (contact)

PROGRAM_OFFICER_NAME: ANDERSON, AFROUZ AZARI

PROJECT_TERMS: 3-Dimensional;Address;Algorithms;Anatomy;Animal Model;Biological;Biological Process;biological systems;Biology;Biomedical Research;Blood;Blood capillaries;Blood flow;blood flow measurement;Brain;Cancer Biology;Cardiac;career;Categories;cell motility;Cell Physiology;Cells;Characteristics;Clinical;Clinical Research;clinically relevant;Color;Compensation;Coronary Circulation;cost;Data;Development;Disease;EFRAC;Electrocardiogram;Erythrocytes;Fiber;Fluorescence Microscopy;Foundations;frontier;Generations;Heart;Heart Diseases;Heart failure;heart imaging;heart motion;Heart Research;Histology;Hypertension;Image;image reconstruction;imaging approach;imaging capabilities;Imaging Techniques;Immunology;improved;in vivo;Injury;insight;instrument;intravital imaging;knowledge base;Label;Lasers;Lead;Left;Left ventricular structure;Location;Measurement;Medical;Metabolic;Metabolic stress;Methods;Microscope;Microscopy;Modeling;Motion;mouse model;Mus;Myocardium;Neurosciences;new technology;next generation;non-invasive optical imaging;novel;Operative Surgical Procedures;Optics;Organ;Organ Model;Pathologic Processes;Penetration;Performance;perfusion imaging;Photons;Physiologic pulse;Physiology;Predisposition;Preparation;preservation;Process;programs;Property;Protocols documentation;reconstruction;Reproduction;Research;Research Activity;Resolution;respiratory;Running;Scanning;Scientist;Signal Transduction;Source;Structure;Surface;System;Techniques;Thick;three photon microscopy;Time;Tissue imaging;Tissues;Training;Transgenic Mice;Translating;two photon microscopy;two-photon;Ventricular;Vision;Visualization;Work

PROJECT_TITLE: Toward fast and deep imaging of living tissue with cellular resolution


NIH_SPENDING_CATS: Biotechnology;Contraception/Reproduction;Genetics;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

ORG_DEPT: BIOLOGY

PHR: Project Narrative Stem cells are special cells that replicate many times over to give rise to all the tissues of the body in an embryo, replenish the tissues of the body over the life of an organism, and make the sperm and egg cells that go on to make the next generation. I study the relationship between stem cells and their supportive niche cells in a microscopic worm called C. elegans, which has many of the same cellular features as humans. I propose to follow up on my recent discovery that the niche and associated cells grow dramatically to support the stem cells, encourage their proliferation, and help them make sperm and eggs.

PI_NAMEs: GORDON, KACY LYNN (contact)

PROGRAM_OFFICER_NAME: SALAZAR, DESIREE LYNN

PROJECT_TERMS: Adhesions;Adult;Animals;Area;Behavior;Biological Models;Cadherins;Caenorhabditis elegans;Candidate Disease Gene;candidate identification;Cell division;Cell Fate Control;cell growth;Cell Proliferation;Cells;Cellular Structures;Complex;Cues;daughter cell;Development;egg;Embryo;follow-up;Genes;genetic analysis;genetic manipulation;Germ Cells;germline stem cells;Goals;Gonadal structure;Growth;Health;Human;imaging study;in vivo imaging;insight;Larva;Life;loss of function;Maintenance;Mediating;Microscopic;Modeling;Molecular;neglect;next generation;Organism;pandemic disease;Pathway interactions;programs;Proliferating;Regulation;Research;RNA Interference;self-renewal;Somatic Cell;Specific qualifier value;sperm cell;stem cell division;stem cell fate;stem cell model;stem cell niche;stem cell population;stem cell proliferation;stem cells;Stimulation of Cell Proliferation;Structure;success;System;Tissues;transcriptome sequencing;Undifferentiated;Work

PROJECT_TITLE: Extreme cell growth in support of stem cell proliferation and niche exit

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Down Syndrome;Hearing Loss;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric

ORG_CITY: MADISON

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

PHR: The proposed supplement is relevant to the INCLUDE project, in which the parent grant focuses on adults with Down Syndrome (DS), specifically, associations between hearing status, auditory function, cognition, language and brain imaging through functional and structural approaches. This supplement aims to collect pilot data in children with DS, as there is a paucity of auditory studies in this population, with known incidence of hearing loss in infants and children with being much higher than in the general population. This supplement will provide pilot data in children with DS, establishing feasibility for a new parent R01 on auditory function and its association with cognition, language and brain structure and function in children with DS.

PI_NAMEs: ALEXANDER, ANDREW L;HARTLEY, SIGAN L;LITOVSKY, RUTH Y (contact)

PROGRAM_OFFICER_NAME: KING, KELLY ANNE

PROJECT_TERMS: Adult;Affect;Age;Area;Attention;Auditory;Auditory area;Auditory Brainstem Responses;Auditory Evoked Potentials;auditory processing;Auditory system;Basic Science;behavior measurement;Brain;Brain imaging;Brain region;Centers for Disease Control and Prevention (U.S.);Child;clinical practice;Cognition;Cognitive;cohort;Communication;Community Integration;comorbidity;Data;Data Set;Development;Developmental Delay Disorders;Developmental Disabilities;Diffusion;Down's Syndrome;Ear;Electroencephalography;executive function;Functional disorder;General Population;Goals;Hearing;hearing impairment;hearing screening;Hearing Tests;high reward;high risk;human old age (65+);Image;Impairment;improved;Incidence;Individual;Infant;Intellectual and Developmental Disabilities Research Centers;Intervention;Investigation;Knowledge;Language;Leadership;Learning;Magnetic Resonance Imaging;magnetic resonance imaging/electroencephalography;Manuscripts;Measures;Memory;Methods;Minor;morphometry;Names;Neurocognition;Neurocognitive;neuroimaging;Newborn Infant;Outcome;parent grant;Parents;Participant;Phenotype;Population;Process;Publications;recruit;Reporting;Research;Research Institute;Resources;Sampling;screening;sensory input;sound;Sound Localization;Speech;speech in noise;standardize measure;statistics;Structure;success;Testing;Universities;Vocabulary;Wisconsin;young adult

PROJECT_TITLE: Auditory function, cognition, language and brain structure in Down Syndrome- Admin Supplement


PHR: NARRATIVE Enhancer regulatory elements play essential roles in development and cell function through gene regulation, and dysregulation of enhancers contributes to various human diseases. The objective of our parental R35 program is to investigate the regulations of enhancer dynamics and assembly in response to signaling and their functional importance. To understand the functional attributes of different enhancer components, we require support from this supplemental equipment grant to purchase a user-friendly cell analyzer with a high- throughput sampler for our planned CRISPR screen experiments.

PI_NAMEs: LIU, ZHIJIE "JASON"  (contact)

PROJECT_TERMS: Acute;Affect;Behavior;Binding;Bioinformatics;Biological Models;Biotin;candidate identification;cell analyzer;Cell Physiology;Cells;Chromatin;Chronic;Chronic Disease;combinatorial;CRISPR screen;Development;Disease;Disease Progression;DNA;Enhancers;Equipment;ESR1 gene;experimental study;Fluorescence;Foundations;Gene Expression;Gene Expression Regulation;genetic approach;Genetic Transcription;Genomic approach;Grant;Hormone Receptor;hormone therapy;Hormones;human disease;imaging approach;imaging system;in vivo;innovation;Label;Ligand Binding;Malignant Breast Neoplasm;Mediating;Molecular;multiple omics;National Institute of General Medical Sciences;Phase;Physical condensation;Play;Prevention approach;programs;protein protein interaction;Proteins;Regulation;Regulatory Element;Research;Resistance;response;Role;Series;Signal Transduction;Site;System;Tamoxifen;Technology;Tissues;transcription factor;Transcriptional Activation;user-friendly

PROJECT_TITLE: Mechanisms of enhancer dynamics and assembly in gene regulation


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: NARRATIVE The type 1 secretion system (T1SS) widely exists in many Gram-negative bacterial pathogens and secretes a variety of toxins which contribute to their virulence. This interdisciplinary study exploits single particle cryo-electron microscopy (cryo-EM), biochemical and in vivo approaches to dissect the structures and mechanisms of the T1SS. The study will provide a new basis for developing future therapeutic interventions against a range of bacterial infections.

PI_NAMEs: MI, WEI  (contact)

PROJECT_TERMS: Adaptor Signaling Protein;Adenylate Cyclase;ATP-Binding Cassette Transporters;Bacterial Adhesins;Bacterial Genome;Bacterial Infections;Biochemical;Bioinformatics;Bordetella pertussis;Cryoelectron Microscopy;Cytoplasm;extracellular;Future;Gram-Negative Bacteria;Hemolysin;Immune response;in vitro Assay;in vivo;Interdisciplinary Study;Invaded;Knowledge;Membrane;Modeling;Molecular;Nature;particle;pathogen;pathogenic bacteria;Pathway interactions;periplasm;Protein Secretion;Proteins;Regulation;Research;Salmonella enterica;Structure;System;Therapeutic Intervention;Tissues;Toxin;Uropathogenic E. coli;VDAC1 gene;Virulence

PROJECT_TITLE: Molecular Mechanisms of the Type I Secretion System from Bacterial Pathogens

STUDY_SECTION: BBM

STUDY_SECTION_NAME: Biochemistry and Biophysics of Membranes Study Section[BBM]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biodefense and Related Countermeasures;Brain Disorders;Dementia;Emerging Infectious Diseases;Eye Disease and Disorders of Vision;Infectious Diseases;Macular Degeneration;Neurodegenerative;Neurosciences;Vector-Borne Diseases

ORG_DEPT: BIOPHYSICS

PHR: PUBLIC HEALTH RELEVANCE Proteins involved in host-pathogen interactions and innate immunity play fundamental roles in human health and are major targets for therapeutic drug development. Elucidating their structures will provide important information for advancing medical research.

PI_NAMEs: MARASSI, FRANCESCA M (contact)

PROGRAM_OFFICER_NAME: TAYLOR, VERONICA

PROJECT_TERMS: Address;Administrative Supplement;age related;Age related macular degeneration;Alzheimer's Disease;Bacterial Outer Membrane Proteins;Blood Proteins;Cell Adhesion;cell motility;Cell surface;Complement;Deposition;design;Diagnostic;Disease;drug development;Environment;Goals;Health;Hemostatic function;Host Defense;Human;Immunity;Knowledge;knowledge base;Lipids;Medical Research;Membrane Proteins;microbial;multidisciplinary;Natural Immunity;Parents;pathogen;Pathogenesis;pathogenic bacteria;pathogenic microbe;Pathologic;Play;Preventive;Process;Proteins;public health relevance;recruit;Research;Research Project Grants;Role;solid state nuclear magnetic resonance;stressor;structural biology;Structure;targeted treatment;Techniques;Therapeutic;Yersinia pestis

PROJECT_TITLE: Administrative Supplement to Membrane Protein Effectors of Pathogen Interactions With Host


NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: IOWA CITY

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: PROJECT NARRATIVE Mechanistic understanding of the fundamental molecular mechanisms of how single-stranded DNA intermediated are channeled in the cell into specific genome maintenance pathways can be exploited in developing novel therapeutics targeting cancer, ageing and neurodegenerative conditions. Structure and architecture of the dynamic nucleoprotein complexes containing these intermediates in key to understanding their function. Robust data processing enabled by the EI-FLEX will allow us to facilitate mechanistic understanding of these complexes and their manipulation for therapeutic purposes.

PI_NAMEs: SPIES, MARIA  (contact)

PROGRAM_OFFICER_NAME: REDDY, MICHAEL K

PROJECT_TERMS: Acceleration;Affinity;age related neurodegeneration;Aging;Architecture;Award;Binding;Binding Proteins;Binding Sites;Biochemical;Biophysics;Blood;Brain Diseases;CAG repeat;Cells;Collaborations;Communication;Complement;Complex;computerized data processing;Cryoelectron Microscopy;Data;Decision Making;Defect;Diffusion;DNA;DNA Binding Domain;DNA biosynthesis;DNA Damage;DNA Folding;DNA lesion;DNA metabolism;DNA Repair;DNA Repeat Expansion;DNA Replication Damage;DNA replication fork;DNA Structure;DNA-Directed DNA Polymerase;drug discovery;Event;Expanded DNA Repeat;Fluorescence;Fluorescence Microscopy;Fluorescence Resonance Energy Transfer;follow-up;Funding;G-Quartets;gain of function;gain of function mutation;Genome;Genome Stability;Goals;Grant;helicase;homologous recombination;Human;Human Pathology;Huntington Disease;In Vitro;in vivo;Individual;instrument;Kinetics;laser tweezer;Macromolecular Complexes;Maintenance;Malignant Neoplasms;melting;Modeling;Molecular;Molecular Conformation;molecular dynamics;Molecular Machines;monomer;mutant;Nerve Degeneration;Neuromuscular Diseases;new therapeutic target;novel;Nucleoproteins;optic tweezer;overexpression;Paper;Parents;Pathogenesis;Pathway interactions;Photometry;Physiological;Poly T;Preparation;Primates;Process;programs;Property;Proteins;Rapid screening;reconstitution;repaired;replication factor A;Request for Applications;Research;Signal Transduction;single molecule;single-molecule FRET;Single-Stranded DNA;structural biology;Structure;Surface;Syndrome;System;telomere;Therapeutic;Time;United States National Institutes of Health;Universities;Variant;Visualization;Work

PROJECT_TITLE: Assembly and Dynamics of Molecular Machines in Genome Maintenance


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Lung;Orphan Drug;Precision Medicine;Rare Diseases;Tuberculosis

ORG_CITY: LOS ANGELES

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: Narrative This project addresses a critical limitation of existing culture-based markers used in Phase 2b/c trials by advancing the validation and qualification of the RS ratio as a novel and highly sensitive molecular tool that enables the detection of Mtb activity beyond the limits of culture.

PI_NAMEs: ALDROVANDI, GRACE M (contact)

PROGRAM_OFFICER_NAME: LIVNAT, DANIELLA

PROJECT_TERMS: Acceleration;Address;AIDS clinical trial group;analytical method;arm;Award;bactericide;Biological;Biological Assay;Biological Markers;California;candidate marker;Cause of Death;Certification;Characteristics;Clinical;Clinical Laboratory Improvement Amendments;clinical risk;Clinical Trials;Collaborations;Colony-forming units;Colorado;design;Detection;Development;Diagnosis;Documentation;drug development;Guidelines;HIV;HIV Infections;Human;improved;Laboratories;Liquid substance;Measurable;Measurement;Medical;Methods;microbial;Molecular;Mus;Mycobacterium tuberculosis;novel;novel therapeutics;Pathway interactions;Patients;Performance;Persons;pharmacodynamic biomarker;Pharmacodynamics;Phase;phase 3 testing;practical application;predict clinical outcome;preservation;Process;programs;Qualifying;Regimen;Relapse;Reproducibility;Residual Neoplasm;Residual state;Resources;Ribosomal RNA;Risk;RNA;RNA chemical synthesis;rRNA Precursor;Sampling;San Francisco;Sputum;Statistical Data Interpretation;Technology Transfer;Testing;Time;tool;treatment effect;Tuberculosis;tuberculosis drugs;tuberculosis treatment;United States Food and Drug Administration;United States National Institutes of Health;Universities;Validation

PROJECT_TITLE: Validation, CLIA and Qualification (VQC): Enhancing the RS ratio as a tool for AIDS Clinical Trial Group (ACTG) tuberculosis trials


ORG_CITY: LA JOLLA

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

PHR: Project Narrative Natural product chemical space (NP space) embodies small molecules that are preoptimized for organismic compatibility. This proposal describes the invention of new chemistry to access, interrogate and modify secondary metabolites that already demonstrate neuromodulatory or antiproliferative phenotypes. These studies lay the foundation for the development of new tools to study human disease and new therapeutics to alleviate it.

PI_NAMEs: SHENVI, RYAN ASHOK (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TITLE: Unusual Pharmacophores and New Tools for Cross-Coupling


PHR: PROJECT NARRATIVE We propose to perform heterologous SHIV challenge of 12 NHPs serially immunized with HIV vaccine candidate NFL trimers that induced cross-neutralizing antibodies to CH505 virus and other clinical isolates as proof-of- principle toward an effective HIV-1 vaccine to improve public health.

PI_NAMEs: WYATT, RICHARD THOMAS (contact)

PROGRAM_OFFICER_NAME: SINGH, ANJALI

PROJECT_TERMS: Adjuvant;Animals;Antibodies;Antigens;Apical;Autologous;B-Lymphocytes;Back;Binding;Budgets;Charge;Clinical;Collaborations;Control Animal;Data;density;Dose;experimental study;Funding;Germ Lines;Grouping;Hand;HIV;HIV vaccine;HIV-1 vaccine;Human;Immunity;Immunize;immunogenicity;Immunoglobulin G;improved;Liposomes;Macaca;Maps;Mediating;Messenger RNA;Monoclonal Antibodies;Mucous Membrane;neutralizing antibody;nonhuman primate;novel;pathogenic virus;Personal Communication;Population;Proteins;Public Health;Recombinants;Regimen;response;Science;Series;Serum;simian human immunodeficiency virus;Testing;United States National Institutes of Health;Vaccinated;vaccine candidate;Vaccines;Virus;Virus Diseases;ward

PROJECT_TITLE: Eliciting neutralizing antibodies and B cell responses using novel HIV Env immunogens in non-human primates


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_CITY: AUSTIN

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

PHR: Project Narrative: This study centers cell movements called convergent extension which are controlled by a set of proteins called the planar cell polarity (PCP) proteins. These experiments will be significant because convergent extension is essential for neural tube closure and limb morphogenesis, and failure of these movements results in a human birth defects such as neural tube defects and skeletal dysplasia. Thus, experiments proposed here will shed new light on mechanisms underlying human congenital anomalies.

PI_NAMEs: WALLINGFORD, JOHN B (contact)

PROGRAM_OFFICER_NAME: MUKHOPADHYAY, MAHUA

PROJECT_TERMS: Actins;Actomyosin;Adhesions;Animals;Award;Behavior;Biological;Biological Process;C cadherin;Cadherins;Cell Adhesion;cell behavior;cell motility;Cell Polarity;cell type;Cell-Cell Adhesion;Cells;Cellular biology;cofilin;Collaborations;Congenital Abnormality;congenital anomaly;convergent extension;Cytoskeleton;Defect;Development;Developmental Biology;Etiology;experimental study;Failure;Genetic;genetic regulatory protein;Goals;Human;Image;in vivo;in vivo imaging;insight;Integral Membrane Protein;Limb structure;Link;Mediating;Morphogenesis;Movement;Neural Tube Closure;Neural Tube Defects;Organ;Pattern;planar cell polarity;protein protein interaction;Proteins;Proteomics;Set protein;Signal Transduction;skeletal dysplasia;Speed;success;superresolution imaging;System;Time;Tissues;UPK3 gene;Vertebrates;Work

PROJECT_TITLE: Control of collective cell movement by planar cell polarity signaling

STUDY_SECTION_NAME: Development - 2 Study Section[DEV2]


FUNDING_MECHANISM: NON SBIR/STTR CONTRACTS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Pregnancy;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: ROCKVILLE

ORG_NAME: THE EMMES COMPANY, LLC

PI_NAMEs: SHERMAN, SETH  (contact)

PROJECT_TERMS: 18 year old;Address;Affect;Age Months;Beginning of Life;Behavior;biobank;Biological;Biological Markers;Birth;Characteristics;Child Development;Child Rearing;Childhood;childhood adversity;Clinical;clinical research site;cohort;Collection;Contracts;COVID-19 pandemic;Data;Data Collection;Data Coordinating Center;Data Management Resources;data platform;data quality;Data Set;design;Development;Discrimination;Disease;Disparity;Documentation;economic disparity;Eligibility Determination;Enrollment;Ensure;Environment;ethnic diversity;Ethnic Origin;Etiology;Evaluation;Family;Fathers;fetal;First Pregnancy Trimester;follow up assessment;follow-up;Generations;Gestational Age;Health;health disparity;improved;Individual;Inequality;Infant;Infant Development;Infant Health;Intervention Studies;Interview;Interviewer;Knowledge;knowledge base;Life;Life Cycle Stages;Link;Literature;Maternal Health;Measurement;Measures;Mediating;Medical Records;Mental Health;Methods;Monitor;Names;National Institute of Child Health and Human Development;Neighborhoods;Neonatal;Neurocognitive;neurodevelopment;Newborn Infant;observational cohort study;Observational Study;offspring;Outcome;outcome disparities;pandemic disease;Parents;Participant;Patient Recruitments;Patient Self-Report;perceived stress;Performance;Persons;Phase;Phenotype;physical conditioning;Play;Population;population health;postnatal;Poverty;Pregnancy;Pregnant Women;prenatal;Procedures;prospective;protective factors;Psychiatric Diagnosis;Psychopathology;Race;racial disparity;racial diversity;recruit;Research;Research Design;Risk Factors;Role;Sampling;Services;Site;social disparities;Social support;Socioeconomic Status;socioeconomics;Source;Spanish;Strategic Planning;Stressful Event;substance use;System;Testing;theories;Training;Translations;transmission process;Umbilical Cord Blood;United States;United States National Institutes of Health;Update;Visit;Woman

PROJECT_TITLE: DATA COORDINATING CENTER FOR THE PRENATAL AND CHILDHOOD MECHANISMS OF HEALTH DISPARITIES: FOLLOW-UP OF THE FIRST SUBCOHORT AND INITIATION OF RECRUITMENT OF THE SECOND SUBCOHORT OF PREGNANT WOMEN


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;HIV/AIDS

ORG_CITY: YEMASSEE

ORG_NAME: ALPHA GENESIS INC

ORG_STATE: SC

PI_NAMEs: WESTERGAARD, GREG  (contact)

PROJECT_TERMS: Animal Experimentation;Biomedical Research;Breeding;Caring;China;clinical practice;Contracts;cooperative study;COVID-19 pandemic;Ensure;Funding;germ free condition;Health;Histocompatibility;Macaca;Macaca fascicularis;Maintenance;mature animal;Monitor;National Institute of Allergy and Infectious Disease;nonhuman primate;offspring;programs;Research;Research Design;Research Personnel;Rhesus;Source;Translating;Translational Research;Transplantation Tolerance;United States National Institutes of Health;Work

PROJECT_TITLE: MAINTENANCE OF NIAID SPECIFIC PATHOGEN-FREE MACAQUE BREEDING COLONIES


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Pediatric;Prevention;Social Determinants of Health

ORG_NAME: WESTAT, INC.

PI_NAMEs: DRIVER, BARBARA  (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Adolescent;Adult;Affect;Africa South of the Sahara;Age;Asia;Award;behavioral and social science;Brazil;Caring;Childhood;clinical development;Clinical Protocols;Clinical Research;clinical research site;Clinical Trials;Collection;Communicable Diseases;Communication;Communities;Comprehensive Health Care;Continuity of Patient Care;Contracts;Country;data infrastructure;data management;Development;Education;education research;Effectiveness;effectiveness/implementation study;Ensure;Equipment;Family;Funding;Geography;Goals;Grant;Health;Health system;HIV;HIV Infections;Human Resources;implementation science;improved;Incidence;Income;Individual;Information Systems;Infrastructure;innovation;Intervention;Laws;Leadership;Mission;Monitor;multidisciplinary;National Institute of Child Health and Human Development;National Institute on Minority Health and Health Disparities;Outcome;performance site;Policies;Population;Prevention;prevention service;programs;Public Health;public health intervention;Public Health Practice;Publications;Qualifying;Research;Research Activity;research clinical testing;Research Personnel;Research Project Grants;Research Support;Resource-limited setting;Risk;Services;social science research;Statistical Models;Structure;Study models;success;Surveys;Translating;Translations;U-Series Cooperative Agreements;United States National Institutes of Health;Viral;web site;Work;working group;Youth

PROJECT_TITLE: SUPPORT SERVICES FOR THE PREVENTION AND TREATMENT THROUGH A COMPREHENSIVE CARE CONTINUUM FOR HIV-AFFECTED ADOLESCENTS IN RESOURCE CONSTRAINED SETTINGS IMPLEMENTATION SCIENCE NETWORK


ORG_CITY: WILMINGTON

ORG_NAME: PPD DEVELOPMENT LP

PI_NAMEs: GLESSNER, MARY  (contact)

PROJECT_TERMS: Clinical Research;clinical research site;Clinical Trials;Conduct Clinical Trials;Contracts;Ensure;Immune Tolerance;International;Monitor;National Institute of Allergy and Infectious Disease;Regulation;Research Personnel;research study;Services;symposium

PROJECT_TITLE: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES (NIAID) CLINICAL SITE MONITORING CENTER (CSMC)


ADMINISTERING_IC: VA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: Veterans Affairs

ORG_CITY: HOUSTON

ORG_NAME: MICHAEL E DEBAKEY VA MEDICAL CENTER

PHR: The Houston Health Services Research & Development (HSR&D) Center for Innovations in Quality, Effectiveness and Safety (IQuESt) has been continuously funded by HSR&D since 1990, providing strong scientific leadership and institutional infrastructure dedicated to a model of embedded health system research. We have a nearly 20-year tradition of conducting research in partnership with the health care delivery system and responding to its needs, making us pioneers in the execution of the learning health care system model in VHA. The IQuESt mission, “Improving health and well-being through innovations in health care delivery”, conveys our commitment to transformative and innovative research that is aligned with VHA national priorities. IQuESt is ideally poised to contribute to making care more accessible, safer, and more patient-centered with innovative research, rapid implementation of evidence, novel methodologies, solid partnerships, stakeholder engagement, career development of scientists, and infrastructure to promote the learning health care system in VHA.

PI_NAMEs: PETERSEN, LAURA A (contact)

PROJECT_TERMS: Biological Models;career development;Caring;Dedications;Effectiveness;Funding;Health;health care delivery;Health Services Research;Health system;Healthcare Systems;improved;Infrastructure;innovation;Institution;Leadership;Learning;Methodology;Mission;Modeling;novel;patient oriented;Personal Satisfaction;Research;research and development;Safety;Scientist;Solid;System;systems research

PROJECT_TITLE: Center for Innovations in Quality, Effectiveness, and Safety (IQuESt)

STUDY_SECTION_NAME: HCN1 COIN REVIEW[HCN1]


ORG_CITY: MINNEAPOLIS

ORG_NAME: MINNEAPOLIS VA  MEDICAL CENTER

ORG_STATE: MN

PHR: The mission of the Center for Care Delivery and Outcomes Research (CCDOR) is to develop and evaluate interventions and implementation strategies that improve health care delivery, Veteran engagement in health care, and Veterans' health and functioning in their communities. CCDOR's vision is to elevate the quality, consistency and equity of health care and outcomes for all Veterans through innovative health services and implementation research. CCDOR is a vibrant health services research center of 26 core investigators leading research in Trauma Recovery (Priority 1) and Chronic Pain and Opioid Harms Reduction (Priority 2), as well as conducting and promoting research in additional areas including cancer prevention and control, health aging, and other timely topics. CCDOR has deep and strong partnerships with VA Program Offices, including the Office of Mental Health and Suicide Prevention, the National Center for PTSD, and National Pain Management. These and other partnerships ensure the value and impact of Center research.

PI_NAMEs: FU, STEVEN  (contact)

PROJECT_TERMS: acronyms;Aging;Area;Cancer Control;cancer prevention;care delivery;care outcomes;chronic pain;Communities;community based participatory research;community engagement;data management;Dedications;Disease;Ensure;Equitable healthcare;Evidence based practice;experience;Family;functional outcomes;Goals;Harm Reduction;Health;health care delivery;Health Services;Health Services Research;health training;Healthcare;Healthcare Systems;healthy aging;implementation research;implementation strategy;improved;Informatics;innovation;Intervention;Mental Health;Mentors;Methodology;Methods;Mission;Names;Opioid;Outcome;Outcomes Research;Pain management;Pain Research;Positioning Attribute;Post-Traumatic Stress Disorders;preservation;programs;Research;Research Personnel;Resources;Services;statistics;Strategic Planning;Structure;success;Suicide prevention;Training;Trauma;Trauma recovery;Veterans;Vision


ORG_CITY: PORTLAND

ORG_NAME: PORTLAND VA MEDICAL CENTER

ORG_STATE: OR

PHR: Not applicable.

PI_NAMEs: DOBSCHA, STEVEN K (contact)

PROJECT_TERMS: Area;career development;Caring;Collaborations;Decision Making;Dissemination and Implementation;empowerment;Ensure;experience;Faculty;falls;Family;Feedback;Fellowship;Goals;Health;Health Services Research;Healthcare;Healthcare Systems;improved;innovation;Malignant neoplasm of lung;member;Mental Health;Methodology;Mission;non-opioid analgesic;operation;Opioid;Oregon;Pain;Pain management;Patient-Centered Care;Personal Satisfaction;prescription opioid;Process;Research;Research Methodology;Research Personnel;Safety;Science;Self Care;Site;Substance Use Disorder;Suicide prevention;Support System;Technology;Universities;Veterans;whole health

PROJECT_TITLE: Center to Improve Veteran Involvement in Care (CIVIC)


ORG_CITY: HINES

ORG_NAME: EDWARD HINES JR VA HOSPITAL

PHR: The Center of Innovation for Complex Chronic Healthcare (CINCCH) is a HSR&D COIN based at Hines VA Hospital. CINCCH's mission is to conduct research to optimize coordination and contextualization of healthcare delivery and improve outcomes for Veterans with high priority neurologic conditions, disseminate and implement best evidence, and train future researchers. We utilize innovative direct observation methods to collect data that compliments other forms of data to assess quality and patient experiences. CINCCH collaborates with several VA Operations Partners and is affiliated with three universities in the Chicago area. In addition, we have established a Veterans Engagement Panel that provides feedback on grant proposals and dissemination activities. Our COIN's vision is to create the evidence and implement the findings to support and guide VA in providing the best care in the right place at the right time.

PI_NAMEs: WEAVER, FRANCES M. (contact)

PROJECT_TERMS: Address;Antibiotics;Applications Grants;Appointment;Area;Award;bone health;Books;care coordination;career;Caring;Centers for Disease Control and Prevention (U.S.);Chicago;Chronic;Chronic Care;Collaborations;Complex;Data;decubitus ulcer;Disease;Doctor of Medicine;Doctor of Philosophy;experience;Faculty;Feedback;Funding;Future;health care delivery;Health Care Research;Health Services;Healthcare;Homelessness;Homogeneously Staining Region;Hospitals;Illinois;improved;improved outcome;innovation;Institution;instrument;Kidney Diseases;Leadership;Life;Medicare;Mentors;Methods;Mission;Modeling;Modernization;Neurologic;operation;Paper;Patient-Centered Care;Patients;Persons;pharmacy benefit;Physical Medicine;Physical Rehabilitation;programs;Renal dialysis;Research;Research Personnel;Respiratory Tract Infections;Scientist;Services;Source;Spinal cord injury;telehealth;Time;Training;Universities;Veterans;Vision;Weight Gain;Weight maintenance regimen;Work


ORG_NAME: VA GREATER LOS ANGELES HEALTHCARE SYSTEM

PHR: The VA HSR&D Center for the Study of Healthcare Innovation, Implementation & Policy (CSHIIP) has had a fundamental role in the ongoing transformation of VA health care, through critical examination of multilevel determinants of variations in VA care, development and testing of innovative healthcare delivery models that improve the effectiveness and value of VA care, and impact on VA practice and policy through implementation and spread of evidence-based practice. Our work is anchored in a longstanding history of high-impact research through career development, support, and engagement of a multidisciplinary cadre of investigators, leveraging extensive partnerships that have infused our mission, vision, and values with a deep understanding of VA priorities. These partnerships and priorities have guided our strategic planning, enabling us to build a portfolio of highly responsive research in key focused (primary care, women’s health, high-risk/high-need groups) and emerging areas (complementary/integrative health, specialty care, and emergency management).

PI_NAMEs: YANO, ELIZABETH M (contact)

PROJECT_TERMS: Academy;Acceleration;acute care;Adoption;Affect;Area;care coordination;care delivery;career development;Caring;Collaborations;Communication;Complementary Health;Comprehensive Health Care;Development;Disasters;Discipline of Nursing;Dissemination and Implementation;Doctor of Philosophy;Effectiveness;Emergency Situation;Employee;Employee Engagement;Evaluation;evidence base;Evidence based practice;experience;Funding;Gender;Goals;harassment;Health;Health system;Healthcare;high risk;Home;Homelessness;Homogeneously Staining Region;implementation science;improved;innovation;Integrative Medicine;Intervention;Leadership;Los Angeles;Medical;Medical center;medical schools;medical specialties;Medicine;Mentors;Methodology;Methods;Mission;Modeling;multidisciplinary;Neighborhoods;novel;older adult;operation;Outcome;Paper;Patients;Policies;Primary Care;Provider;provider behavior;Public Health;Publishing;Quality of Care;Readiness;Recording of previous events;recruit;Research;Research Personnel;resilience;Role;Safety;scale up;Scientific Advances and Accomplishments;Service delivery model;Services;severe mental illness;Site;Strategic Planning;substance use;System;Testing;tool;Training;United States Agency for Healthcare Research and Quality;United States Centers for Medicare and Medicaid Services;United States National Institutes of Health;Variant;Veterans;Vision;whole health;Woman;Women's Health;Women's Health Services;Work;Workplace


ORG_CITY: WEST HAVEN

ORG_NAME: VA CONNECTICUT HEALTHCARE SYSTEM

PHR: This application proposes the continuation of a Center of Innovation (COIN), called the Pain Research, Informatics, Multimorbidities, and Education (PRIME) Center. The COIN builds on the successes of our existing PRIME Center at VA Connecticut Healthcare System. The goals of the PRIME Center are to conduct research to improve care for all Veterans with a specific focus on pain management and women's health. The Center also fosters innovative research in emerging areas like suicide prevention and CHOICE care. Through a Veteran Engagement Group, the Center strives to be Veteran-centric. Investigators provide research mentoring to train the next generation of VA health services researchers. To achieve its goals, the PRIME Center is supported by partnerships with VHA Patient Care Services and Operations leaders, especially the Pain Management Program and Women's Health Services, as well as a large number of cross-COIN and other VHA medical center collaborations.

PI_NAMEs: BASTIAN, LORI A (contact)

PROJECT_TERMS: Area;Award;behavioral health;Behavioral Sciences;care systems;career;career development;Caring;Chronic;Clinical;Collaborations;Complementary Medicine;Connecticut;Disparity;Eating Disorders;Education;Electronic Health Record;Fostering;gender difference;Goals;Health;health data;Health Services;Health Services Research;Healthcare;Healthcare Systems;High Prevalence;implementation research;implementation science;improved;Informatics;Infrastructure;innovation;Institution;Integrative Medicine;Intervention;Leadership;Medical;Medical center;Medical Informatics;medical schools;medical specialties;Mental Health Services;Mentors;Minority;Mission;multimodality;Neurology;New England;next generation;operation;Opioid;Pain;Pain management;Pain Research;Patient Care;Patient-Centered Care;Primary Care;programs;Reproductive Health;Research;Research Methodology;Research Personnel;sex;Strategic Planning;success;Suicide;Suicide prevention;System;Technology;Training;Veterans;Woman;Women's Health;Women's Health Services

PROJECT_TITLE: Pain, Research, Informatics, Multimorbidities, Education


ORG_CITY: PITTSBURGH

ORG_NAME: VETERANS HEALTH ADMINISTRATION

ORG_STATE: PA

PHR: The Veterans Health Administration (VA) provides care for individuals who are more likely to be racial and ethnic minorities, older, and poorer than the general population. Although VA provides a health care safety net, disparities in health and health care exist for many vulnerable Veteran populations and are associated with increased risks of disability, illness, and death. In addition to individual, provider, and health system factors, disparities may originate outside of the health care system and involve personal behaviors and social and community influences. As a health system committed to delivering high-quality, equitable care to all Veterans, VA must identify vulnerable populations, understand the root causes of disparities, and assess interventions to eliminate them. The Center for Health Equity Research and Promotion's mission is to advance the quality and equity of health and health care for vulnerable Veterans.

PI_NAMEs: FINE, MICHAEL JONAH (contact);LONG, JUDITH A

PROJECT_TERMS: Address;behavioral economics;Big Data;Caring;Cessation of life;Clinical;clinical care;clinical epidemiology;Clinical Trials;Collaborations;Communities;community advisory board;Community Healthcare;Data Analyses;Decision Analysis;design;Development;disability risk;Discipline;Disparity;Ensure;Equity;ethnic minority;General Population;Genomics;Goals;Health;Health behavior change;health disparity;health equity;Health equity research;Health Services Research;Health system;Healthcare;Healthcare Systems;implementation science;improved;Individual;Infrastructure;innovation;Institution;Intervention;Knowledge;Leadership;Medical center;medical specialties;medication safety;Mentors;Meta-Analysis;Methods;military veteran;Mission;Outcome;Pattern;Pennsylvania;Personal Behavior;Pharmacologic Substance;pharmacy benefit;Policies;Program Development;programs;Provider;Psychometrics;Publications;Qualitative Research;racial minority;Records;Research;Research Personnel;Research Training;Safety;safety net;Scientific Advances and Accomplishments;Services;Site;social;Technology Assessment;Therapeutic;tool;Training;Training and Education;Translating;Universities;Veterans;Veterans Health Administration;Vulnerable Populations;Work

PROJECT_TITLE: Center for Health Equity Research and Promotion (CHERP)


ORG_NAME: IOWA CITY VA MEDICAL CENTER

PHR: The Center for Access and Delivery Research and Evaluation (CADRE) is seeking to renew its Center of Innovation (COIN) funding to advance research and improve access for Veterans. We aim to build upon our existing expertise, established operational partnerships, and long-term research objectives through prioritizing five overarching goals that align with our focused areas of research and emerging priorities. GOAL 1: Improve access to high quality care for rural Veterans through innovative applications of telehealth in specialty care, community care, and dual use. GOAL 2: Develop and evaluate interventions targeting the multidrug-resistant organism crisis. GOAL 3: Expand efforts in developing innovative health services research in three additional areas: (1) women’s health, (2) epidemic opioid use and substance use disorders, and (3) cardiovascular outcomes. GOAL 4: Continue the Center’s success in supporting mentored career development. GOAL 5: Promote Veteran engagement with recognition that Veterans are experts on Veteran experience.

PI_NAMEs: PERENCEVICH, ELI N (contact)

PROJECT_TERMS: Address;Area;barrier to care;Cardiovascular system;career development;Caring;Centers for Disease Control and Prevention (U.S.);Cities;Communities;Community Healthcare;connected care;design;digital intervention;Endocrinologist;Enrollment;Equity;Evaluation;experience;Face;Fertility;Funding;Goals;health care availability;Health Services Research;Healthcare Systems;Improve Access;improved;innovation;Internet;Intervention;Iowa;Leadership;medical specialties;meetings;Mentors;multi-drug resistant pathogen;operation;opioid epidemic;opioid use;Outcome;pharmacy benefit;Poverty;Prevention;Provider;Publishing;Quality of Care;Recommendation;reproductive;Research;Research Personnel;Research Priority;Resources;Rural;rural area;Rural Health;rural setting;Scientist;Services;Substance Use Disorder;success;telehealth;Universities;Veterans;Women's Health;Women's Health Services

PROJECT_TITLE: Center for Access & Delivery Research and Evaluation (CADRE)


ORG_CITY: SEATTLE

ORG_NAME: VA PUGET SOUND HEALTHCARE SYSTEM

ORG_STATE: WA

PHR: The Center of Innovation (COIN) for Veteran-Centered and Value-Driven Care has had outstanding productivity and impact on Veteran healthcare and well-being through the application of the National Academy of Medicine's learning health system. In the past 3 years, our 47 investigators generated ~$47 million in operating revenue, published 583 manuscripts, and led 113 projects across our research, implementation science, operational projects/program evaluations and training programs. Our dual-site Center will continue to address our two focus areas: 1) promote Veteran-centered care to improve patient experiences across VA healthcare and community settings and 2) advanced value-driven care by providing Veterans the highest quality care at the lowest financial burden. Building on our prior success, we will continue to partner with operational leaders and our Veteran Engagement Board to innovate new research, implementation science, and operational programs as well as train the next generation of outstanding research leaders.

PI_NAMEs: AU, DAVID H (contact);HO, P. MICHAEL

PROJECT_TERMS: Academy;Address;Area;Award;care delivery;career development;Caring;clinical care;Colorado;Communities;community setting;Complex;Congresses;Deimplementation;disparity elimination;Evaluation;experience;Faculty;Financial Hardship;Funding;geographic disparity;health care service;health care settings;Health Services;Health Services Accessibility;Health Services Research;Health system;Healthcare;Healthcare Systems;implementation science;improved;improved outcome;innovation;Intervention;Knowledge;Lead;Learning;Manuscripts;Medical center;medical specialties;Medicine;Mental Health Services;Methods;Mission;next generation;novel strategies;Paper;Patient Compliance;patient oriented;Patient Outcomes Assessments;Patient-Centered Care;Patients;Personal Satisfaction;Policies;Postdoctoral Fellow;Primary Care;primary health service;Productivity;Program Evaluation;programs;Provider;Psyche structure;Publishing;Quality of Care;Research;research clinical testing;Research Personnel;Rural Health;Safety;satisfaction;Self Management;Site;socioeconomic disparity;sound;Statutes and Laws;success;Suicide prevention;Training;Training Programs;Translating;United States National Institutes of Health;Universities;Veterans;Washington;Women's Health;Work;Workforce Development

PROJECT_TITLE: Seattle-Denver Center of Innovation for Veteran-Centered and Value-Driven Care


ORG_CITY: INDIANAPOLIS

ORG_NAME: RLR VA MEDICAL CENTER

ORG_STATE: IN

PHR: Given Veterans' increasing choices about where and how they receive care, successful coordination of care will require improving effective communication among a variety of individuals and entities, as well as improved management and use of health information. This project supports the Center for Health Information and Communication, of the U.S. Department of Veterans Affairs Health Services Research & Development Service. The Center's mission is to improve Veterans' health care through innovative research on health information, technology, and communication. The Center's vision is to improve Veterans' health through innovative applications of health information and health information systems that serve the population-based and interpersonal needs of patients and health professionals. The Center will generate knowledge about the impact of the Department's investment in health information technology, and will determine how systems-based and interpersonal communication of health information can improve delivery and outcomes of care.

PI_NAMEs: WEINER, MICHAEL  (contact)

PROJECT_TERMS: Address;alternative treatment;Area;cancer care;care coordination;care outcomes;career development;Caregivers;Caring;chronic pain;chronic pain management;Clinical;clinical decision support;clinical practice;Communication;Communities;computer human interaction;connected care;Decision Making;Dissemination and Implementation;Documentation;Electronic Health Record;Foundations;Funding;Goals;Health;health application;health communication;Health Information System;health information technology;Health Professional;Health Sciences;Health Services Research;Health Technology;Healthcare;improved;Individual;Information Management;innovation;Investments;Knowledge;Mediation;Mental disorders;Mental Health;Mentors;Mission;Office Management;operation;Opioid;Outcome;Pain management;Patients;person centered;Personal Communication;Pharmaceutical Preparations;Policies;population based;Positioning Attribute;programs;Provider;Publications;Research;research and development;Safety;Science;Scientist;Services;skills;Stroke;System;Technology;tool;Translations;Veterans;Veterans Health Administration;virtual;Vision;Work


NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Pediatric;Physical Injury - Accidents and Adverse Effects;Prevention;Unintentional Childhood Injury

ORG_CITY: COLUMBUS

ORG_NAME: RESEARCH INST NATIONWIDE CHILDREN'S HOSP

PHR: PROJECT NARRATIVE Teen drivers who have committed a traffic violation are at increased risk for crashes, injuries, and deaths. Through partnership with the local Juvenile Traffic Court, this randomized controlled trial will assess the effectiveness of an innovative in-vehicle driving feedback technology, with and without parent training, on reducing risky driving events, unsafe driving behaviors, and recidivism among high-risk teen drivers, which correlates with NICHD’s mission to prioritize research on teen driver safety.

PI_NAMEs: YANG, JINGZHEN GINGER (contact)

PROGRAM_OFFICER_NAME: DIXON, CINNAMON ANNE

PROJECT_TERMS: Acceleration;Adolescent;Age;Appearance;Automobile Driving;Behavior;Cause of Death;Cessation of life;Communication;comparison control;Control Groups;County;court;Devices;distracted driving;driving behavior;driving safety;effective intervention;Effectiveness;effectiveness evaluation;Enrollment;Event;Evidence based program;Fatality rate;Feedback;Frequencies;Goals;group intervention;Hearing;high risk;high risk population;improved;improved outcome;Injury;innovation;Intervention;intervention effect;Legal Guardians;Licensing;Measures;Mission;National Institute of Child Health and Human Development;novel;Ohio;Outcome;Outcome Study;parenting intervention;Parents;Phase;Policies;prevent;programs;Randomized;Randomized, Controlled Trials;recidivism;recruit;Research;Research Priority;Risk;risky driving;Safety;Seat Belts;smartphone application;Specialist;Speed;Summary Reports;Supervision;System;Technology;technology training;teen drivers;teen driving;Teenagers;Testing;therapy design;Time;Training;United States;universal prevention;unsafe driving;Vehicle crash;virtual

PROJECT_TITLE: Intervention to Improve Driving Practices Among High-Risk Teen Drivers

STUDY_SECTION: CLHP

STUDY_SECTION_NAME: Community-Level Health Promotion Study Section[CLHP]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Arthritis;Behavioral and Social Science;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Dissemination and Implementation Research;Mental Health;Pain Research;Pediatric;Prevention

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: PROJECT NARRATIVE There is a critical need to improve the long-term physical and psychosocial outcomes of adolescents with chronic musculoskeletal pain (CMP) in order to reduce healthcare utilization and mitigate the psychosocial sequelae of ongoing chronic pain in this vulnerable patient population. The goal of the proposed research is to examine the impact of a resilience coaching program adapted for adolescent chronic musculoskeletal pain in a pilot randomized controlled trial (RCT). Achievement of the study aims has the potential to be a significant contribution to building and fostering resilience among adolescents with chronic musculoskeletal pain, as the proposed research will inform a future multicenter RCT of the resilience coaching program and thereby augment current interdisciplinary management of adolescent CMP.

PI_NAMEs: GMUCA, SABRINA ANDREA (contact)

PROGRAM_OFFICER_NAME: WANG, YAN Z

PROJECT_TERMS: acceptability and feasibility;Achievement;Address;Adolescent;Adolescent and Young Adult;Adult;Affect;Age;aged;Anxiety;arm;behavioral health intervention;bone;burden of illness;career;career development;Caregivers;Caring;Child;Child health care;Child Psychology;Childhood;Chronic Childhood Arthritis;Chronic Disease;chronic musculoskeletal pain;chronic pain;chronic pain management;Clinical;Clinical Trials;Clinical Trials Design;Cognitive;Cognitive Therapy;cohort;Collaborations;comorbidity;Complement;Data;Development;Educational Intervention;Effectiveness;efficacy evaluation;enhanced care;experience;Face;Feedback;Fostering;functional disability;Future;future implementation;Goals;health care service utilization;implementation efforts;implementation evaluation;implementation intervention;implementation outcomes;implementation science;Improve Access;improved;innovation;insight;Institution;inter-individual variation;interdisciplinary approach;Intervention;Interview;Investigation;Joints;K-Series Research Career Programs;Knowledge;Learning;Lupus;Medical Care Costs;Mental Depression;Mentorship;Methods;mindfulness;Multicenter Trials;multidisciplinary;Muscle;novel;Occupational;Outcome;Pain;Pain intensity;pain outcome;Pain Research;Parents;Participant;patient population;Patients;Pediatric Hospitals;pediatric rheumatic diseases;Pennsylvania;Persistent pain;Phase;Philadelphia;pilot trial;Population;post intervention;preference;prevent;primary outcome;Process;programs;promote resilience;Provider;psychologic;psychological distress;psychosocial;Psychosocial Factor;psychosocial outcome;Randomized, Controlled Trials;Recommendation;remote delivery;Research;Research Methodology;Research Personnel;resilience;Resources;rheumatologist;Rheumatology;Role;routine care;Scientist;secondary outcome;Severities;sex;skills;Societies;soft tissue;stress management;Structure;Surveys;Symptoms;Teenagers;tertiary care;theories;Training;treatment as usual;Treatment outcome;Treatment Protocols;treatment responders;treatment response;Universities;Work;Youth

PROJECT_TITLE: A Pilot Randomized Controlled Trial of Resilience Coaching for Adolescents with Chronic Musculoskeletal Pain

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Physical Injury - Accidents and Adverse Effects;Wound Healing and Care

ORG_DEPT: PLASTIC SURGERY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative The proposed research is relevant to public health because it will facilitate and vertically advance the development of critically needed medical countermeasures against chemicals induced skin injuries. The proposed mechanistic studies will facilitate understanding the dynamics of the key processes involved in the chemicals induced injuries that will have an enormous impact on our capabilities to design countermeasure strategies and test them directly on human skin using our novel model system. This whole process will shorten the time for developing countermeasure and increase the chances of success in clinical translation Thus, the proposed research is relevant to the NIH/NIAID/Chemicals Countermeasure Program’s mission to develop new countermeasures and add them to the national stockpile.

PI_NAMEs: EJAZ, ASIM  (contact)

PROGRAM_OFFICER_NAME: KOCH, PETER

PROJECT_TERMS: Abdomen;Acceleration;adiponectin;adipose derived stem cell;Advanced Development;Anatomy;Apoptosis;Apoptotic;Appearance;Area;Arsenicals;arsine;Biological Models;Bioreactors;Blood Vessels;Bulla;Cannulations;CASP3 gene;Cell Death;cell injury;Cell Nucleus;Cell Separation;cell type;Cells;Characteristics;Chemical Agents;chemical countermeasure;Chemical Injury;Chemicals;Cicatrix;Clinic;Clinical;clinical translation;Collaborations;Consumption;Controlled Environment;Dermal;design;Development;DNA Damage;Dose;Down-Regulation;efficacy testing;Ensure;Environment;Erythema;Evaluation;experience;Exposure to;Extracellular Matrix;Fibroblasts;Fibrosis;Fresh Tissue;Funding;Future;Gene Expression;Gene Expression Profiling;Genes;Glucose;Goals;Guidelines;Histologic;Hour;Human;Human Resources;human tissue;In Situ Nick-End Labeling;Inflammation;Injury;innovation;insight;Knowledge;Laboratories;Legal patent;Mechlorethamine;medical countermeasure;Metabolic;Metformin;Mission;Modeling;Molecular;Monitor;mouse model;Mus;National Institute of Allergy and Infectious Disease;Necrosis;novel;novel therapeutics;Operative Surgical Procedures;Outcome;Oxides;Pain;Pathway interactions;Perfusion;Physiological;Plastic Surgical Procedures;Population;Positioning Attribute;Postdoctoral Fellow;pre-clinical;pressure;Probability;Process;Production;programs;Proliferating;Protective Devices;Proteins;Public Health;Quality of life;Radiation;Reaction;Reporting;Research;research clinical testing;Research Support;response;response to injury;Risk;screening;single cell sequencing;Site;Skin;skin fibrosis;Skin injury;Skin wound healing;Specimen;Stains;Stimulus;success;Symptoms;System;Temperature;Testing;Time;tissue injury;Tissue Viability;Tissues;tool;Toxic effect;Toxicant exposure;Training;Training Programs;Translations;United States National Institutes of Health;vasoconstriction;Vasodilation;Vesicants;wasting;weapons of mass destruction;wound healing

PROJECT_TITLE: Explant human skin perfusion model to study mechanisms of chemical injury and mitigation


ORG_CITY: ANN ARBOR

ORG_STATE: MI

PHR: Not applicable

PI_NAMEs: KERR, EVE A (contact)

PROJECT_TERMS: Achievement;Adverse event;Alcohols;Area;Award;behavioral economics;Cannabis;care coordination;care delivery;career;Caring;Chronic;Cladribine;Clinical;clinical center;Clinical Management;Collaborations;Communities;Community Healthcare;Complex;Critical Illness;Data Collection;Development;digital data;Disease Progression;disorder prevention;Effectiveness;experience;Family;Funding;Future;Health;Health Promotion;Health Services Accessibility;Health Services Research;Healthcare;Healthcare Systems;high risk;Homogeneously Staining Region;Hospitalization;implementation research;improved;Infrastructure;innovation;Inpatients;Intervention;investigator training;Knowledge;Measurement;Measures;Mental Health;mHealth;Michigan;Mission;Modernization;multidisciplinary;opioid misuse;Outcome;patient engagement;patient oriented;Patient Outcomes Assessments;patient safety;Patient-Centered Care;Patients;peer support;Performance;Physicians;Play;predictive modeling;Prevention;Primary Care Physician;Productivity;programs;Reporting;Research;Research Infrastructure;Research Personnel;Role;Safety;Scientist;screening;Services;square foot;suicidal risk;Suicide prevention;System;Technology;theories;tool;Training;United States National Institutes of Health;Veterans;Vision;Wages

PROJECT_TITLE: Ann Arbor COIN Renewal Application


ORG_CITY: BOSTON

ORG_NAME: VA BOSTON HEALTH CARE SYSTEM

ORG_STATE: MA

PHR: The Center for Healthcare Organization and Implementation Research has a mission to conduct organizationally-partnered, and Veteran-partnered research in order to develop, implement, and evaluate evidence-based and innovative practices that improve Veterans Health Administration (VA) healthcare. Our priority goals are: (1) to advance the field of HSR by sustaining, developing, and growing our existing, scientific focus areas, and growing our evolving and emerging scientific areas; (2) to enrich VA's cadre of world-class HSR investigators, by supporting training and education across the career spectrum; and (3) to grow and support innovation in order to maintain VA at the cutting edge of HSR and adapt to meet VA's ever- changing needs.

PI_NAMEs: BOKHOUR, BARBARA G.;GIFFORD, ALLEN L (contact)

PROJECT_TERMS: Address;Adherence;Adverse event;Area;Behavioral;Boston;care coordination;care systems;career;career development;Caring;Collaborations;Communication;community living;connected care;Decision Making;Development;Diffusion of Innovation;Educational process of instructing;Elderly;Elements;Environment;evidence base;Face;Future;Geriatrics;Germination;Goals;health care service organization;Health Service Area;Health Services Administration;Health Services Research;Healthcare;Homelessness;implementation research;improved;Incubators;innovation;International;Justice;K-Series Research Career Programs;Long-Term Care;Long-Term Care for Elderly;Measurement;Measures;Medication Management;Mental Health;Mentors;Mission;Modeling;Operative Surgical Procedures;Outcome;patient oriented;Patient Outcomes Assessments;patient safety;Patient-Centered Care;Patients;Pharmaceutical Preparations;Pharmacologic Substance;pharmacy benefit;Postdoctoral Fellow;Primary Care;Process;programs;Recovery;Research;Research Personnel;Resources;Safety;Scientist;Standardization;success;Suicide prevention;Surgeon;System;team-based care;Technology;Testing;Training and Education;Training Support;Transition Career Development Award (K22);Universities;Veterans;Veterans Health Administration;Vulnerable Populations;whole health;Work


ORG_CITY: NORTH LITTLE ROCK

ORG_NAME: CENTRAL ARKANSAS VETERANS HLTHCARE SYS

ORG_STATE: AR

PHR: The Center for Mental Healthcare & Outcomes Research (CeMHOR) is an HSR&D Center of Innovation whose mission is to optimize health and well-being of Veterans through innovative research to improve access to and engagement in evidence-based care for mental health and substance use disorders and prevent suicide. CeMHOR accomplishes its mission by partnering directly with Veterans, clinical leaders, and front-line providers to develop feasible and effective interventions to address top VA and national priorities. CeMHOR expertise in implementation science leads to widespread uptake of these interventions. CeMHOR investigators are also experts in rural health and community engagement. CeMHOR research will apply this expertise to include Veterans who are not receiving VA care, as well as those who use VA services but do not fully engage in needed care. In addition to two focus areas, mental health care access/engagement and suicide prevention, investigators conduct research to address opioid misuse and abuse and advance implementation science.

PI_NAMEs: OWEN, RICHARD R. (contact)

PROJECT_TERMS: Address;Ambulatory Care Facilities;American;Area;Arkansas;Awareness;behavioral health;career development;Caring;clay;Clergy;Clinical;Collaborations;Communities;community college;community engagement;Community Outreach;community setting;Demographer;design;Development;effective intervention;Effectiveness;Epidemiologist;Evaluation;evidence base;Federally Qualified Health Center;gaps in access;Goals;Health;health care availability;Health Services;Health Services Research;Healthcare Systems;implementation intervention;implementation science;Improve Access;improved;innovation;Intervention;Knowledge;Location;Managed Care;Medical;Mental disorders;Mental Health;mental health center;Mental Health Services;Mentors;Methods;Mind;Mission;Modeling;opioid abuse;opioid misuse;opioid use disorder;Outcomes Research;peer support;Personal Satisfaction;Pharmacists;Prevention;Prevention strategy;Primary Care;Professional counselor;programs;Provider;Psychiatrist;Psychologist;Research;Research Personnel;Resources;Risk;Rural;rural area;Rural Community;Rural Health;Science;Services;Social Workers;sociologist;Substance Use Disorder;Suicide prevention;Testing;Training;Translating;Universities;uptake;Veterans;virtual healthcare;Work


ORG_CITY: SALT LAKE CITY

ORG_NAME: VA SALT LAKE CITY HEALTHCARE SYSTEM

ORG_STATE: UT

PHR: The Informatics, Decision-Enhancement, and Analytic Sciences (IDEAS) Center of Innovation will conduct research to advance scientific discovery, implement novel interventions, promote cross-center collaboration, increase research capacity, and engage operational partners to improve Veteran health. Our research will focus on the public health threat of antibiotic resistance, on mitigating health risks in Veterans during periods of vulnerability, and on improving medication safety as the Department of Veterans Affairs (VA) transitions to a new electronic health record. Across all of these areas, we study methods to promote the adoption of research findings into clinical practice. In the process, we train the next generation of outstanding VA health services researchers. Veteran and stakeholder engagement is a topmost priority for our Center. All of our research is highly collaborative and integrated with clinical programs.

PI_NAMEs: SAMORE, MATTHEW H (contact)

PROJECT_TERMS: addiction;Adoption;adverse outcome;Antibiotic Resistance;Antibiotics;Antimicrobial Resistance;Area;biomedical informatics;Caring;Cities;Clinical;Clinical Investigator;clinical practice;Cognitive;Collaborations;Community Healthcare;Coupled;Data;Decision Making;Decision Support Systems;design;Discipline;Electronic Health Record;Ensure;Environment;Event;Goals;Guidelines;hazard;Health;health care delivery;health information technology;Health Services;Health Services Research;Health system;Healthcare;Healthcare Systems;healthcare-associated infections;implementation science;improved;Infection prevention;Informatics;Infrastructure;innovation;Intervention;Knowledge;Leadership;Learning;Link;medication safety;Medicine;Mental Health;Methodology;Methods;Military Personnel;Modernization;Natural Language Processing;Nature;next generation;novel;Overdose;patient safety;Pharmacoepidemiology;Population;prediction algorithm;Process;programs;Public Health;Qualitative Research;recruit;Research;Research Activity;Research Personnel;Risk;Rural Health;Safety;Science;Scientific Advances and Accomplishments;simulation;Sodium Chloride;Source;stakeholder perspectives;Statistical Models;success;suicidal;System;Therapeutic;tool;Training;Translational Research;Traumatic Brain Injury;Trust;United States Department of Veterans Affairs;Veterans;Veterans Health Administration;Vision;Visualization

PROJECT_TITLE: IDEAS 3.0


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Biotechnology;Cancer;Precision Medicine

ORG_CITY: ALLSTON

ORG_NAME: APERTURE BIO, INC.

PHR: PROJECT NARRATIVE Nearly two thirds of new cancer patients fail treatment due to resistance that is not fully understood. Aperture Bio’s single cell proteomics platform can provide rapid single-cell molecular analyses to enable improvements over current diagnostics, ultimately improving patient treatment options and outcomes. This project further develops and validates the proprietary technology in addition to producing new, proprietary analytical software to create a comprehensive tumor T cell panel, with the ultimate goal of ensuring that every lab can employ single cell methods.

PI_NAMEs: PETERSON, HANNAH MARIE (contact)

PROGRAM_OFFICER_NAME: REGMI, SAROJ GOPAL

PROJECT_TERMS: Adoption;Biological Markers;biomarker development;Biopsy Specimen;Cancer Patient;Cells;Clinical;Clinical Trials;commercialization;Complex;Computer software;Cytometry;Data;Development;Diagnostic;diagnostic tool;Drug Targeting;Ensure;Flow Cytometry;Goals;Immune;Immunofluorescence Immunologic;improved;Methods;Microscope;Molecular Analysis;next generation;Oncologist;Outcome;Pathology;Patient Selection;Patients;Population;Precision cancer therapy;precision oncology;preservation;protein expression;Proteomics;Research;Resistance;Sample Size;Sampling;Services;T-Lymphocyte;Technology;tool;Translating;Treatment outcome;tumor

PROJECT_TITLE: Rapid, Single Cell Proteomic Profiling for Biomarker Development in Precision Oncology


ORG_NAME: UNIVERSITY OF UTAH

PHR: Project Narrative Chronic, low-grade inflammation is a contributing factor to most diseases associated with aging. However, the molecular and cellular mechanisms that regulate chronic inflammation are still being deciphered. We will determine how specific regulatory microRNAs function to control age-dependent inflammatory status through their regulation of T cell metabolism, recruitment of inflammatory myeloid cells, and control of senescence-associated secretory phenotypes, and our work will identify novel therapeutic targets to treat this harmful condition.

PI_NAMEs: DRUMMOND, MICAH J;O'CONNELL, RYAN M (contact)

PROGRAM_OFFICER_NAME: GUO, MAX

PROJECT_TERMS: Activities of Daily Living;aerobic glycolysis;Age;age related;age related chronic disease;aged;Aging;aging population;Anti-Inflammatory Agents;Autoantibodies;Autoimmunity;Biochemical;Biological Assay;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;cell type;Cells;Cellular Metabolic Process;chemokine;Chronic;Cladribine;Clinic;Clinical;clinically relevant;comorbidity;conditional knockout;Data;Diabetes Mellitus;Disease;extend lifespan;frailty;Functional disorder;Gene Expression;gene function;Genes;Glycolysis;Heart Diseases;Helper-Inducer T-Lymphocyte;Human;Immune response;improved;Inflammaging;Inflammation;Inflammatory;inflammatory marker;inhibitor;innovation;insight;insulin sensitivity;Investigation;Knockout Mice;Life;life span;Link;Malignant Neoplasms;Mediating;Metabolic;Metabolic Control;Metabolic Diseases;Metabolism;MicroRNAs;Modeling;Molecular;Mus;muscle strength;Muscle Weakness;Myelogenous;Myeloid Cells;Nerve Degeneration;new therapeutic target;novel;novel marker;Obesity;older adult;Organ;Outcome;Participant;Pathogenicity;Pathology;Pathway interactions;Phenotype;Play;Population;Prevalence;prevent;Process;Production;programs;recruit;Regulation;Reporting;Research;Risk Factors;Role;senescence associated secretory phenotype;Serum;single-cell RNA sequencing;Societies;stem;T cell regulation;T-Lymphocyte;T-Lymphocyte Subsets;targeted treatment;Therapeutic;Time;Tissues;tool;Translating;Work;young adult

PROJECT_TITLE: MicroRNA regulation of chronic inflammation during aging

STUDY_SECTION: CMAD

STUDY_SECTION_NAME: Cellular Mechanisms in Aging and Development Study Section[CMAD]


NIH_SPENDING_CATS: Biotechnology;Cancer

ORG_CITY: State College

ORG_NAME: ATLAS BIOLOGICS, LLC

PHR: Targeted therapies have revolutionized patient care for a wide range of cancers, but are fundamentally limited by acquired resistance mutations. Current technologies used in industry to evaluate the mutational landscapes of next generation targeted therapies are incomplete, limited in sensitivity, and retrospective. This project proposes to develop and commercialize deep mutational scanning with duplex sequencing (DMS-DS), the most comprehensive and accurate platform available for measuring the mutational landscape of investigational targeted therapies.

PI_NAMEs: REYNOLDS, JOSHUA  (contact)

PROJECT_TERMS: Acceleration;anti-cancer;Antineoplastic Agents;bcr-abl Fusion Proteins;Businesses;Cancer Patient;cancer type;Cause of Death;Cells;Clinical;Clinical Trials;commercialization;Complex;design;Development;Drug Design;drug development;Drug Evaluation;Drug Targeting;effective therapy;Evolution;Frequencies;Grant;improved;Industry;inhibitor;lead candidate;Libraries;Malignant neoplasm of lung;Malignant Neoplasms;Measurement;Measures;Methods;mutant;Mutation;mutation screening;next generation;next generation sequencing;Outcome;Patient Care;Pharmacologic Substance;Phase;Positioning Attribute;prevent;Prognosis;Proteins;Research;Resistance;resistance mutation;response;screening;sequencing platform;Services;targeted agent;targeted treatment;Techniques;Technology;tool;treatment planning

PROJECT_TITLE: Development of Deep Mutational Scanning with Duplex Sequencing (DMS-DS) for anti-cancer drug evaluation and administration


ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

PI_NAMEs: O'CONNER, PHD, DAVID  (contact)

PROJECT_TERMS: Alleles;Animals;Biological Assay;Catalogs;Communities;Complementary DNA;Data Analyses;data curation;Development;exome sequencing;Fc Receptor;gene discovery;Gene Frequency;Genetic Services;genome sequencing;genomic data;Genomic DNA;Genotype;genotyping technology;Immune System Diseases;Immunoglobulins;improved;Infectious Diseases Research;Killer Cells;Knowledge;Laboratories;Libraries;Macaca fascicularis;Macaca mulatta;Major Histocompatibility Complex;member;Modeling;National Institute of Allergy and Infectious Disease;nonhuman primate;Population;Pre-Clinical Model;programs;public database;receptor;Receptor Gene;Research;Resolution;Technology;technology development;Transplantation;whole genome

PROJECT_TITLE: Non-human primate MHC and KIR Allele Discovery and Typing Technology Development


NIH_SPENDING_CATS: Clinical Research

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

PROJECT_TITLE: CORONARY ARTERY RISK DEVELOPMENT IN YOUNG ADULTS (CARDIA) STUDY - COORDINATING CENTER (CC)