NIH_SPENDING_CATS: Biotechnology;Drug Abuse (NIDA only);Fentanyl Misuse and Addiction;Immunization;Neurosciences;Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Prevention;Substance Misuse;Vaccine Related

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: Public health narrative. The United States has seen dramatic increases in fatal overdoses due to heroin, counterfeit prescription opioids, and cocaine adulterated with fentanyl or fentanyl-like compounds. The present project will address this issue by developing vaccines directed against fentanyl and fentanyl-like compounds, offering a safe and cost-effective strategy to reduce illicit opioid use and likelihood of fatal overdose in opioid users and individuals in professions at high-risk of accidental overdoses from occupational exposure to fentanyl and fentanyl analogs (e.g., law enforcement or airport personnel). We propose to develop fentanyl vaccines, and to perform studies that would allow them to enter clinical trials.

PI_NAMEs: PRAVETONI, MARCO  (contact)

PROGRAM_OFFICER_NAME: SOUSA, JASON CARLOS

PROJECT_TERMS: abuse liability;Accidents;Address;Adjuvant;Adsorption;Agonist;aluminum sulfate;analog;antagonist;Antibodies;Antibody Affinity;Antibody Response;antinociception;B-Lymphocytes;Behavior;Benchmarking;Bradycardia;Brain;Buprenorphine;Canada;carfentanil;Carrier Proteins;Categories;Chemicals;Clinical Trials;Cocaine;Complementary therapies;Conjugate Vaccines;Conjugated Carrier;Contracts;cost effective;cost effective intervention;cross reactivity;Data;Development;drug distribution;Drug Prescriptions;efficacy testing;endogenous opioids;Epidemic;Escherichia coli;Europe;Exposure to;Family;Fentanyl;fentanyl analog;fentanyl overdose;fentanyl self-administration;Follow-Up Studies;Formulation;Funding;Guidelines;Haptens;Heroin;high risk;Human Resources;illicit opioid;Immunization;Immunize;in vivo;Incidence;Individual;industry partner;Industry Standard;Keyhole Limpet Hemocyanin;Law Enforcement;Lead;lead optimization;Licensing;Maintenance;manufacture;Manufacturer;manufacturing organization;medication-assisted treatment;Methadone;Modeling;Mus;Naloxone;Naltrexone;Occupational Exposure;Occupations;Opioid;opioid overdose;opioid use;opioid user;Overdose;overdose death;Overdose reduction;Oxycodone;Pharmaceutical Preparations;Pharmacotherapy;Phase;Positioning Attribute;pre-clinical;preclinical development;prescription opioid;Public Health;Rattus;Recombinants;Regimen;remifentanil;research clinical testing;response;Risk;Safety;Security;Series;Site;Testing;tetanus toxin fragment C;TLR9 gene;Toxicology;United States;vaccine development;vaccine efficacy;vaccine evaluation;vaccine formulation;vaccine trial;Vaccines;Ventilatory Depression

PROJECT_TITLE: Vaccines for fentanyl and its derivatives: A strategy to reduce illicit use and overdose


ADMINISTERING_IC: GM

ARRA_FUNDED: N

ED_INST_TYPE: GRADUATE SCHOOLS

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics

ORG_CITY: NEW YORK

ORG_COUNTRY: UNITED STATES

ORG_DEPT: GENETICS

ORG_FIPS: US

ORG_NAME: ROCKEFELLER UNIVERSITY

ORG_STATE: NY

PHR: Project Narrative Dysregulation of programmed cell death accompanies many disease states, where abnormal death leads to organ and tissue degeneration, while insufficient death leads to cancer. Patients with Huntington’s disease, aggressive cancers, progeria and laminopathies display morphological features of novel non-apoptotic Linker Cell-type Death (LCD) discovered in C. elegans. The discovery of mammalian LCD genes would have immediate applications, from development of new markers to distinguish when LCD is employed in vertebrate development and disease, to suggesting methods for inducing and inhibiting LCD, with a long-term goal of providing in-roads for therapeutics development.

PI_NAMEs: YARYCHKIVSKA, OLGA  (contact)

PROGRAM_OFFICER_NAME: STOKES, KALYNDA K

PROJECT_TERMS: Adult;Advisory Committees;Aging;Animals;Apoptosis;Apoptotic;Automobile Driving;Back;Biological Models;biomarker identification;Caenorhabditis elegans;Caspase;Cell Count;Cell Death;Cell Death Process;Cell division;Cell Division Process;Cell Nucleus;cell type;Cells;Cessation of life;Chromatin;chromatin remodeling;clinically significant;Complex;confocal imaging;Cytoskeleton;Data;Development;Disease;Disseminated Malignant Neoplasm;DNA biosynthesis;Ductal Epithelial Cell;Environment;Epigenetic Process;Event;Exhibits;Faculty;Failure;Funding Opportunities;Genes;Genetic;Goals;Heterochromatin;Histone H1;Histone H2B;histone modification;Histones;Homologous Gene;human disease;Huntington Disease;in vivo Model;Infarction;innovation;insight;Invertebrates;Lamins;Link;male;Malignant Neoplasms;Mammals;Mentors;Mentorship;Methods;Methyltransferase;Mitosis;Modeling;Molecular;Morphology;mouse model;Mus;Mutant Strains Mice;Nerve Degeneration;neuron loss;novel;novel marker;Nuclear;Nuclear Lamin;Nuclear Lamina;Nuclear Structure;Organ;Organ Culture Techniques;Pathogenesis;Pathologic;Patients;Peripheral;Phase;Phenotype;physiologic model;Physiological;Play;polyglutamine;polyglutamine neurodegenerative diseases;Positioning Attribute;post-doctoral training;Postdoctoral Fellow;Process;Progeria;programs;Proteomics;Publishing;Regulation;Reporter;Research;Research Design;Research Proposals;RNA interference screen;Role;Science;Solid;Structure of paramesonephric duct;System;Testing;therapeutic development;tissue degeneration;Tissues;Training;Universities;Work

PROJECT_TITLE: Nuclear and chromatin aberrations during non-apoptotic cell death in C. elegans and mammals


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: STANFORD

ORG_DEPT: PATHOLOGY

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: Project Narrative Aberration of the microtubule-associated tau protein is a pathological hallmark of neurodegenerative diseases collectively known as tauopathies that include Alzheimer's disease (AD). Despite overwhelming evidence implicating defects in mitochondria in general and mitochondrial Complex I in particular in tauopathies, mitochondria and Complex I have not been the focus of therapeutic development targeting tauopathies. This project will test a novel hypothesis on how pathogenic tau may affect mitochondrial Complex I function and has the potential to validate a new therapeutic target for tauopathies and possibly other brain diseases.

PI_NAMEs: LU, BINGWEI  (contact)

PROGRAM_OFFICER_NAME: YANG, AUSTIN JYAN-YU

PROJECT_TERMS: Active Immunization;Affect;age related;age related neurodegeneration;age-related disease;aging related;Alzheimer's Disease;Amyloid;Animal Model;arm;Bacterial Infections;Binding;Bioenergetics;Biological;Brain;Brain Diseases;cancer stem cell;cerebral atrophy;Cognitive deficits;cognitive function;Complex;cytochrome c;Defect;Development;Disease;disease phenotype;drug candidate;Drug Targeting;Electron Transport;Electrons;extend lifespan;Failure;fly;Functional disorder;Genetic;Goals;Human;human disease;human induced pluripotent stem cells;improved;in vivo;induced pluripotent stem cell;Induced pluripotent stem cell derived human neuron;Infection;inhibitor;Inner mitochondrial membrane;interest;knock-down;life span;Link;Macrophage Activation;MAPT gene;Microtubules;Mitochondria;mitochondrial dysfunction;Mitochondrial Proteins;Modeling;Molecular;mouse model;Mus;NADH;Nerve Degeneration;Neurodegenerative Disorders;neuron loss;neuroprotection;new therapeutic target;notch protein;novel;Outcome;oxidation;Passive Immunization;Pathogenicity;Pathologic;pharmacologic;Physiological;Physiological Processes;Post-Translational Protein Processing;prevent;Process;Production;Proteins;Proton Pump;Reactive Oxygen Species;Reperfusion Injury;Respiratory Chain;response;Role;Senile Plaques;Signal Transduction;Site;small molecule;Succinates;tau aggregation;tau interaction;tau mutation;tau Proteins;Tauopathies;Testing;Therapeutic;therapeutic development;therapeutic target;Thermodynamics;Toxic effect;ubiquinol;Ubiquinone;β-amyloid burden

PROJECT_TITLE: Reverse electron transport and tauopathy

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Child Abuse and Neglect Research;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Services;Mental Health;Pediatric;Physical Injury - Accidents and Adverse Effects;Prevention;Social Determinants of Health;Violence Against Women;Violence Research;Women's Health Research

ORG_CITY: NEW HAVEN

ORG_DEPT: PEDIATRICS

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Intimate partner violence (IPV) affects 1 in 4 American women, and surveys of victims suggest that physical child abuse occurs in 30-60% of homes with IPV, but these data have not resulted in the routine evaluation of physical abuse in children exposed to IPV. IPV may serve as a “sentinel” event and may provide an opportunity for early recognition and secondary prevention of physical abuse in a child who is exposed to IPV. In this study, we will identify barriers to and facilitators of the screening of IPV-exposed children who have been reported to a local child protective services agency for exposure to IPV, perform intervention mapping to develop and implement a Family-Centered Care (FCC) model for children and caregivers living with IPV, and finally, conduct a pilot trial of the FCC model to assess its acceptability and feasibility.

PI_NAMEs: TIYYAGURA, GUNJAN  (contact)

PROGRAM_OFFICER_NAME: GILBERT, LEAH KAYE

PROJECT_TERMS: 3 year old;acceptability and feasibility;Accident and Emergency department;Address;Adoption;Adult;Advocate;Affect;American;Belief;care seeking;care systems;career development;Caregiver well-being;Caregivers;Caring;Cessation of life;Child;Child Abuse;Child Advocacy;Child Care;Child Health;child physical abuse;child protective service;Clinical;clinical decision support;Clinical Trials;community engaged research;compare effectiveness;Consensus;Data;Decision Making;design;Detection;Development;Early Diagnosis;Electronics;Eligibility Determination;Enrollment;Ensure;Evaluation;Event;experience;Exposure to;Faculty;Family;Family Study;Family Violence;Future;Goals;Health;health care settings;high risk;Home;Household;implementation science;implementation strategy;improved;improved outcome;Injury;innovation;Intervention;intervention mapping;Interview;intimate partner violence;Knowledge;Leadership;Legal;Legal system;lens;Link;Location;Medical;Mentors;Mentorship;Methods;Modeling;Parents;Patient Self-Report;pediatrician;Pediatrics;physical abuse;Pilot Projects;pilot trial;practical application;primary care clinic;Process;programs;Provider;Randomized;Recording of previous events;Reporting;Research;research clinical testing;Research Personnel;Research Project Grants;response;Risk;Risk Factors;Risk Reduction;Roentgen Rays;Sampling;screening;Secondary Prevention;Sentinel;Services;Shaken baby syndrome;Shelter facility;skills;social;standard of care;Surveys;Systems Integration;theories;Training;treatment as usual;violence exposure;Visit;Woman

PROJECT_TITLE: A Family Centered Approach to Intimate Partner Violence

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Health, Behavior, and Context Study Section[CHHD-M]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: DURHAM

ORG_DEPT: PHARMACOLOGY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE Early detection of cancer holds great promise as a way to identify cancer at a curative stage or recurrent disease before radiologically visible to initiate treatment at a more vulnerable stage of disease. As such, our approach to develop an ultra-sensitive method to detect cancer DNA in the bloodstream has significant clinical implications.

PI_NAMEs: COUNTER, CHRISTOPHER M (contact)

PROGRAM_OFFICER_NAME: HODGES, NICHOLAS AARON

PROJECT_TERMS: Adopted;Antibiotic Resistance;Bacteria;Bar Codes;Basic Science;biobank;Biological Assay;Biopsy;Blinded;Blood;Blood Circulation;Blood specimen;Cancer Biology;cancer care;cancer cell;Cancer Detection;Cancer Patient;cancer type;Carcinogens;Cells;Clinic;Clinical;clinical care;clinical development;Clinical Management;Clinical Trials Design;Colonoscopy;Consent;Coupled;deep sequencing;Detection;detection assay;detection limit;detection sensitivity;Discipline;Disease;DNA;DNA sequencing;driver mutation;Early Diagnosis;Early Intervention;Engineering;experience;Experimental Designs;extracellular vesicles;Genes;head-to-head comparison;Hematopoietic Neoplasms;high risk;Human;improved;Individual;innovation;Institutional Review Boards;KRAS2 gene;liquid biopsy;Malignant neoplasm of gastrointestinal tract;Malignant neoplasm of lung;Malignant Neoplasms;Methods;Microbiology;Molecular;Monitor;Mus;mutant;Mutation;Mutation Detection;mutational status;Neoplasm Circulating Cells;new technology;next generation sequencing;novel strategies;Oncogenic;Oncologist;Pathologist;Patients;Performance;Point Mutation;Population;prospective;Protocols documentation;Publishing;Radiology Specialty;Recurrence;Recurrent disease;Reporting;Reproducibility;Research Personnel;research study;Resected;resistance mutation;Sampling;Scientist;screening;Screening for cancer;Source;Stream;targeted sequencing;Technology;Testing;Tissues;Translating;tumor;tumor DNA;Tumor Tissue

PROJECT_TITLE: Adapting K-MDS to detect KRAS-mutant ctDNA


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Prevention;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: CHICAGO

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE  Alzheimer's Disease and related dementias (ADRD) are a major public health problem. The Dementia Risk Pooling Project (DRPP) will pool and rigorously harmonize 11 prospective observational cohorts to develop an accurate and personalized, dynamic dementia risk prediction model to identify high risk individuals.

PI_NAMEs: ALLEN, NORRINA BAI (contact)

PROGRAM_OFFICER_NAME: YIN, XILING

PROJECT_TERMS: Address;adjudication;Adult;Age;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;American;Area;Behavioral;Calibration;Cardiovascular Diseases;Cardiovascular system;caregiving;Cessation of life;Clinical;clinical care;Clinical Trials;Cloud Computing;cohort;computational platform;Data;data harmonization;Data Set;Dementia;dementia risk;Detection;Development;Disease;Early Intervention;experience;follow-up;Future;Genetic;Grant;health care service utilization;high risk;high risk population;human old age (65+);improved;Incidence;Individual;individualized prevention;International;Intervention;Joints;Life;lifetime risk;Longitudinal cohort;machine learning method;Malignant Neoplasms;Measurement;meetings;Methodology;Methods;middle age;Mission;Modeling;Monitor;Morbidity - disease rate;mortality;National Institute of Neurological Disorders and Stroke;Natural History;Onset of illness;Patients;Persons;Phase;Population;Population Heterogeneity;preclinical trial;predictive tools;prevent;Prevention;Prevention approach;preventive intervention;Preventive therapy;Primary Care;prospective;Public Health;Recommendation;recruit;Research;Research Personnel;Resources;Risk;Risk Factors;risk prediction;risk prediction model;Risk Reduction;risk stratification;Sample Size;Site;Stroke;success;symposium;targeted treatment;Time;tool;Update;vascular cognitive impairment and dementia;vascular risk factor

PROJECT_TITLE: Dementia Risk Prediction Pooling Project


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative Antibodies against factor VIII (inhibitors) occur in 20-30% of patients with severe hemophilia A following life- saving factor VIII replacement therapy, rendering treatment less effective, with no current therapies available to prevent their formation. Type I interferons are cytokines that play a role in the initiating immune steps of inhibitor development and are an attractive potential therapeutic target for decreasing inhibitor formation and/or predicting those patients at risk of developing inhibitors. The ability to prevent or predict inhibitor development will reduce the public health burden associated with the increased morbidity/mortality, decreased quality of life, and significant expense associated with the treatment of hemophilia A patients with inhibitors. .

PI_NAMEs: ZERRA, PATRICIA ELIZABETH (contact)

PROGRAM_OFFICER_NAME: HILL-PRYOR, CRYSTAL DARLEANE-ROBIN

PROJECT_TERMS: Address;Antibodies;Antibody Formation;Antibody Response;Antigens;B-Cell Activation;B-Lymphocytes;care costs;career;career development;CD4 Positive T Lymphocytes;Cells;Child health care;Clinical;Clinical Research;Collaborations;Coupled;cytokine;Data;Development;Disease;Environment;Excision;Exhibits;Factor VIII;Failure;Genetic;genetic signature;Goals;Hematology;Hemophilia A;Hemorrhage;Human;Immune;Immune response;Immune Targeting;Immunology;improved;Individual;Infusion procedures;inhibitor;Injections;insight;Institution;Instruction;Interferon Activation;Interferon Type I;Interferons;Isoantibodies;Life;Mediating;Mentorship;Morbidity - disease rate;mortality;mouse model;National Heart, Lung, and Blood Institute;novel;Pathway interactions;Patients;Pediatric Hematology;Physicians;Population;pre-clinical;Pre-Clinical Model;preclinical study;prevent;Process;prophylactic;Public Health;Quality of life;receptor;Replacement Therapy;Research;research and development;Research Technics;response;Risk;Risk Factors;Role;Sampling;Scientist;side effect;Signal Pathway;Sinus;Spleen;stem;T-Cell Activation;Testing;Therapeutic;therapeutic target;trafficking;Training;transcriptome sequencing;type I interferon receptor;Variant;Welding;Work

PROJECT_TITLE: The Role of Type I Interferons in Factor VIII Inhibitor Formation

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(MA)]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Estrogen;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Sexually Transmitted Infections;Social Determinants of Health;Women's Health Research

ORG_CITY: BOSTON

ORG_NAME: BOSTON MEDICAL CENTER

ORG_STATE: MA

PHR: PROJECT NARRATIVE Transgender individuals have higher rates of HIV and other sexually transmitted infections than cisgender individuals. Transgender men or transmasculine individuals were assigned female sex at birth but identify along the masculine spectrum, and testosterone is often administered to transgender men and other transmasculine persons as part of the treatment for gender reassignment. The goal of this project is to characterize the changes that occur in the vagina as a result of testosterone exposure using a model of vaginal tissue that has been constructed from the cells found in the vagina that will allow us to mimic transmasculine physiology and determine if testosterone alters the tissue in such a way that the immune response is impaired, increasing the risk of HIV infection.

PI_NAMEs: INGALLS, ROBIN R (contact)

PROGRAM_OFFICER_NAME: PORTER, KRISTEN AMY

PROJECT_TERMS: 3-Dimensional;Adult;Affect;Anal Sex;Area;assigned female at birth;Basic Science;Biological Assay;Biomedical Research;Bisexual;Boston;Cells;chemokine;Chronic;cis-male;cisgender;Communities;cultural competence;cytokine;Data;Development;DNA Sequencing Facility;Estradiol;female reproductive tract;female sex hormone;gender affirming hormone therapy;Gene Expression;Gene Expression Profile;Genitalia;Goals;Gonadal Steroid Hormones;Health;health disparity;Healthcare;Heterosexuals;Histologic;Histology;HIV;HIV Infections;HIV risk;HIV-1;Hormonal;hormone therapy;Human immunodeficiency virus test;Immune;Immune response;Immune signaling;Immunologics;Immunology;Impairment;Individual;Infection;interest;Knowledge;Laboratories;Lactobacillus;Ligands;male sex hormones;marginalization;Masculine;Medical;Meta-Analysis;Michigan;microbial;Modeling;Mucins;Mucosal Immunity;Mucous Membrane;non-heterosexual;Organism;pathogen;Penetration;Persons;Physiology;Poly I-C;Prevalence;Regimen;Reporting;Research Personnel;Research Priority;Residual state;response;Risk;Risk Factors;Role;screening;sex;Sex Orientation;Sexual Reassignment;sexual risk behavior;Sexually Transmitted Diseases;Signal Pathway;Sterility;substance use;Surface;Testing;Testosterone;Thick;Tissue Model;Tissues;transcriptomics;transgender;transgender men;transgender women;transmasculine;transmission process;tumor-immune system interactions;United States;United States National Institutes of Health;Universities;Vagina;vaginal microbiome;vaginal mucosa;Work

PROJECT_TITLE: Understanding the effects of cross-sex hormone therapy on vaginal mucosal immunity

STUDY_SECTION: HIVD

STUDY_SECTION_NAME: HIV Immunopathogenesis and Vaccine Development Study Section[HIVD]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_DEPT: NEUROSCIENCES

PHR: Project Narrative: Cognitive decline is a clinical hallmark of late-onset Alzheimer’s disease (LOAD), costing millions of elderly individuals’ quality of life years. Synapse loss is highly correlated with cognitive decline, and seen early in LOAD and aging; while potential neuronal-microglial interactions mediating this loss have been identified, it remains unknown how these interactions are triggered in aging and confer vulnerability to LOAD. This proposal will elucidate specific upstream, age-related neuronal calcium and mitochondrial dysregulation that may trigger synapse loss, providing potential key therapeutic targets to preempt cognitive decline, and thus extending the number of healthy, active years of life.

PI_NAMEs: WOO, ELIZABETH KA-YOON (contact)

PROGRAM_OFFICER_NAME: SARE, RACHEL

PROJECT_TERMS: 3-Dimensional;Acute;Age;age related;aged;Aging;aging related;Agonist;Alzheimer's Disease;association cortex;Biochemistry;Brain;Calcium;Calcium Channel;Calcium Signaling;CASP3 gene;Cell Death;Chronic;Clinical;Cognition;Cognitive deficits;Complement;Complement 1q;cost;Cyclic AMP;Cyclic AMP-Dependent Protein Kinases;Cytosol;Data;Dementia;Dendrites;Disease Progression;Dose;Early Intervention;Elderly;Ensure;Event;Excision;experimental study;Exposure to;familial Alzheimer disease;Generations;Human;Image;Image Analysis;Immunoelectron Microscopy;Immunofluorescence Immunologic;Immunohistochemistry;Impaired cognition;In Situ;In Vitro;in vitro Model;Individual;Inositol;insight;interest;ITPR1 gene;Late Onset Alzheimer Disease;Lead;Life;Macaca;Macaca mulatta;Mediating;Methods;Microglia;Mitochondria;mitochondrial dysfunction;Modeling;Molecular;Morphology;mouse model;Mus;neurodevelopment;Neurofibrillary Tangles;Neurons;neurotransmission;Pathogenesis;Pathway interactions;Patients;Phenotype;Phosphatidylserines;phosphoric diester hydrolase;Phosphorylation;Population;preempt;Process;Quality of life;quantitative imaging;receptor;reconstruction;Research;Resolution;response;Risk Factors;Ryanodine Receptor Calcium Release Channel;Signal Transduction;Smooth Endoplasmic Reticulum;superresolution microscopy;Synapses;Testing;Therapeutic Intervention;therapeutic target;Time;Tissues;tripolyphosphate

PROJECT_TITLE: Investigating the Neuronal Signals Initiating Synapse Loss in Aging and Alzheimer's Disease


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Asthma;Childhood Obesity;Clinical Research;Genetics;Human Genome;Lung;Microbiome;Obesity;Pediatric;Prevention

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative Childhood obesity and asthma are major public health problems for U.S. children but effective strategies to prevent these problems are not available. Leveraging genetic, microbiomic, and clinical data from thousands of demographically diverse children in the NIH ECHO Program, we will examine the causal role of the early-life microbiome in the development of obesity and asthma. This research has the potential to offer a strong evidence base for the future development of targeted microbiome interventions to prevent childhood obesity and asthma.

PI_NAMEs: CAMARGO, CARLOS ARTURO (contact)

PROGRAM_OFFICER_NAME: PARK, CHRISTINA H

PROJECT_TERMS: Affect;Age;Airway Disease;Area;Asthma;Bacteroides;Biological;Boston;CCL7 gene;Child;Child Development;Child Health;Childhood;Childhood Asthma;Clinical;Clinical Data;cohort;Complement 4b;Data;Data Element;Development;Disease;Enrollment;Environment;Environmental Exposure;Epidemiologic Methods;Epidemiology;Ethnic Origin;Ethnic Population;evidence base;Extrinsic asthma;Funding;Future;Genetic;Genetic Variation;Genome;genome wide association study;genomic locus;Genotype;Glucuronates;Goals;gut microbiome;Health;innovation;insight;International;Knowledge;Leadership;Learning;Life;Mendelian randomization;Microbe;microbiome;microbiome composition;microbiome research;microbiome therapeutics;Moraxella;nasal microbiome;neurodevelopment;neuron development;Nose;novel;Obesity;obesity development;obesity in children;obesity-associated asthma;Outcome;Participant;participant enrollment;Pathogenesis;Pathway interactions;Pediatric cohort;Phenotype;Positioning Attribute;prevent;preventive intervention;programs;Protocols documentation;Public Health;pulmonary function;Pulmonary Function Test/Forced Expiratory Volume 1;Race;Regulation;Reporting;Research;Research Personnel;Resources;respiratory microbiome;Risk;Role;Single Nucleotide Polymorphism;Site;social stressor;Statistical Methods;statistics;Streptococcus;Testing;TLR4 gene;United States National Institutes of Health;whole genome;Work;working group

PROJECT_TITLE: Host genetics, early-life microbiome, and childhood asthma: MARC-43 Boston

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-EPH-S(50)R]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: Newark

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: Research Narrative. Brain function requires the coordinated action of hundreds or thousands of intermingled neurons. These neurons form groups to encode sensory perception and motor actions. We will use new technology to see how these groups of neurons influence each other during visually guided actions in a way that has never before been possible.

PI_NAMEs: OLDENBURG, IAN ANTON (contact)

PROGRAM_OFFICER_NAME: FLANDERS, MARTHA C

PROJECT_TERMS: Address;Affect;Animal Behavior;Architecture;Area;awake;Behavior;behavior influence;Behavioral;behavioral outcome;Brain;Cell Communication;Cells;Code;cortex mapping;Cues;design;Detection;Development;Elements;Form Perception;functional group;genetic manipulation;Goals;hippocampal pyramidal neuron;in vivo;Individual;inhibitory neuron;insight;Interneurons;Lead;Link;Maps;Mentors;Methods;Modality;Monitor;Motor;motor behavior;Motor Cortex;Motor output;Movement;multi-photon;Mus;Nature;neural;neural circuit;Neurons;new technology;novel;Opsin;Optics;optogenetics;Output;Pattern;Perception;Phase;Play;Population;Process;Property;Pyramidal Cells;recruit;Recurrence;Research;response;Role;Sensory;sensory stimulus;Signal Transduction;skills;Source;Specificity;Stimulus;System;Techniques;Technology;Time;tool;Training;Visual;Visual Cortex;Visual Perception;Visual System;Writing

PROJECT_TITLE: Editing the Neural Basis of Perception

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE The Michigan Center for Contextual Factors in Alzheimer's Disease (MCCFAD) focuses on the social and behavioral contexts in which Alzheimer's disease and related dementias (ADRD) are experienced. MCCFAD will lead a coordinated effort to advance diversity, equity, inclusion and accessibility in health research focusing on three priority areas: ADRD epidemiology, health economics, and culturally sensitive care as it seeks to diversify the research in and workforce dedicated to ADRD and advance social and behavioral ADRD research among underserved and underrepresented communities. The Center engages directly with Middle Eastern and North African (MENA) and Latino communities, and links with African Americans through its partnerships with Michigan NIA Centers.

PI_NAMEs: AJROUCH, KRISTINE J. (contact);ANTONUCCI, TONI CLAUDETTE;ZAHODNE, LAURA B

PROGRAM_OFFICER_NAME: BANDIERA, FRANK

PROJECT_TERMS: Address;Affect;African American;African American population;Aging;Agreement;Alzheimer's Disease;Alzheimer's disease related dementia;Area;Behavioral;Behavioral Sciences;Brain;Capsicum;Caring;Clinical;Cognitive;Collaborations;Communities;Community Relations;contextual factors;Data;Dedications;Dementia;Development;developmental psychology;Directories;Disparity;Economics;Education;Ensure;Epidemiology;equity, diversity, and inclusion;Event;experience;Faculty;Fostering;Funding;Goals;Health;health disparity;health economics;Health education;health inequalities;health organization;Health Professional;healthy aging;Immersion;improved;Individual;Infrastructure;innovation;Interdisciplinary Study;Knowledge;Language;Latino;Latino Population;Lead;Leadership;Life Cycle Stages;life span;Link;Measurement;Medical;Mentors;Mentorship;Methodology;Methods;Michigan;Middle Eastern;Neuropsychology;North African;older adult;Pathway interactions;Persons;Pilot Projects;Population;programs;Publications;recruit;Research;Research Personnel;Resources;Science;Scientist;social;social culture;Social Sciences;Sociology;Structure;Techniques;underserved community;Underserved Population;Universities;volunteer;Wages;Work

PROJECT_TITLE: MI Center for Contextual Factors in Alzheimer's Disease (MCCFAD) Yrs 6-10


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research

PI_NAMEs: AJROUCH, KRISTINE J. (contact)

PROJECT_TERMS: Address;African American;African American population;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Area;Awareness;Behavioral Research;Behavioral Sciences;Black race;career;Caring;collaborative approach;Communication;Communities;community engagement;community partners;community partnership;computerized;contextual factors;Counseling;Data;Dedications;Development;disparity elimination;education research;Eligibility Determination;Ensure;Epidemiology;equity, diversity, and inclusion;Ethics;Evaluation;experience;falls;First Generation College Students;Funding;Generations;Goals;Health;Health and Retirement Study;health economics;Health Personnel;Health Professional;healthy aging;Immersion;improved;Inequality;Institution;Latino;Latino Population;Lead;Leadership;Letters;Link;meetings;member;Mentors;Michigan;Middle Eastern;Minority;Minority-Serving Institution;multidisciplinary;National Archive;National Institute on Aging;North African;outreach;Pilot Projects;Postdoctoral Fellow;Program Effectiveness;Program Evaluation;programs;Recording of previous events;recruit;Regulation;Research;Research Personnel;Resources;Role;Scientist;social;Social Sciences;Structure;success;supportive environment;Technology;Underrepresented Populations;Underrepresented Students;Underserved Population;Universities;virtual

PROJECT_TITLE: Leadership and Administrative Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Human Genome;Microbiome;Neurodegenerative;Neurosciences

ORG_DEPT: NEUROLOGY

PHR: Project Narrative Astrocytes are important in the progression of Alzheimer's disease (AD), but how they are regulated is not well understood. Recent studies indicate that the microbiome may regulate astrocyte activation, and the proposed research will utilize innovative imaging and RNA sequencing technologies to fully understand the profile of astrocytes upon microbiome perturbation in a mouse model of AD. Sequencing data will be leveraged to understand whether modulation of astrocyte pathways can alter AD pathology and represent a therapeutic strategy for AD.

PI_NAMEs: CHANDRA, SIDHANTH  (contact)

PROJECT_TERMS: 3-Dimensional;abeta deposition;Affect;age related neurodegeneration;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease therapeutic;Amyloid beta-Protein;Animal Model;Antibiotics;Astrocytes;astrogliosis;Back;Bacteria;Brain;Candidate Disease Gene;candidate selection;Cause of Death;Cell Separation;Complement;Complement 1q;confocal imaging;Data;Dementia;Dependovirus;Deposition;design;Development;Disease;Donor person;Elderly;Etiology;experimental study;Future;Gene Expression Profile;Generations;Genes;genetic risk factor;Genetic Transcription;genome wide association study;genome-wide;glial activation;Glial Fibrillary Acidic Protein;Gliosis;gut microbiome;Heterogeneity;Human;Image;Inflammatory;innovation;insight;Interleukins;Intestines;knock-down;male;Mediating;Methods;microbiome;microbiome alteration;Microglia;Modeling;Morphology;mouse model;Mus;Natural Immunity;Nerve Degeneration;Neurodegenerative Disorders;neuroinflammation;Neurons;neurotoxic;novel;Ontology;overexpression;Pathogenesis;Pathologic;Pathology;Pathway Analysis;Pathway interactions;Phenotype;Poison;Polyribosomes;promoter;Publishing;reconstruction;Regulator Genes;release factor;Research;response;Ribosomal Proteins;RNA;Role;Satellite Viruses;Senile Plaques;single-cell RNA sequencing;tau aggregation;Tauopathies;Technology;Therapeutic;therapeutic target;TNF gene;transcriptome;transcriptome sequencing;transcriptomics;Transgenic Mice;Transplantation;United States;vector;Water

PROJECT_TITLE: The gut microbiome in Alzheimer's disease: exploring the role of astrocytes


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research

PI_NAMEs: GONZALEZ, RICHARD D (contact)

PROJECT_TERMS: Acculturation;Address;African American population;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;analytical method;Area;Attention;Behavioral Sciences;Caring;Classification;Code;Cognitive;cognitive testing;Communication;Communities;community collaboration;comparison group;Computer software;Consultations;contextual factors;Data;data access;Data Collection;data curation;data management;data resource;Data Set;data visualization;Dedications;Dementia;Development;Directories;Disparity;Education;educational atmosphere;Ensure;environmental enrichment for laboratory animals;Epidemiology;Equity;equity, diversity, and inclusion;Ethnic Population;experience;Faculty;flexibility;Goals;Grant;health disparity;health economics;healthy aging;Immersion;innovation;Institution;Investigation;Knowledge;Language;Latino;Leadership;Link;Measurement;Measures;meetings;Mentors;Methodology;Methods;Michigan;Middle Eastern;Minority;minority communities;Modeling;Modernization;multidisciplinary;Neuropsychology;North African;novel strategies;Output;Play;Productivity;programs;Property;psychosocial;Publications;racial population;recruit;Research;Research Methodology;Research Personnel;Resources;Role;Sampling;Scientist;Seminal;Series;skills;Social Sciences;success;Techniques;Testing;Underrepresented Populations;Universities;user-friendly;Visualization;volunteer;web site;Work

PROJECT_TITLE: Analysis Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: ROBINSON-LANE, SHERIA GRICE (contact)

PROJECT_TERMS: Acceleration;Address;African American;Aging;aging demography;Alzheimer's Disease;Alzheimer's disease related dementia;Applications Grants;Area;Behavioral;Brain;Capsicum;career;Career Mobility;career networking;Caring;Categories;Cognitive;Collaborations;Communication;Communities;comparative;contextual factors;Data;design;Development;Discrimination;Disparity;Education;education research;Educational workshop;Ensure;Epidemiology;equity, diversity, and inclusion;Ethnic Origin;Evaluation;Event;experience;Faculty;Funding;Goals;Health;Health and Retirement Study;Health Disparities Research;health disparity;health economics;health inequalities;Immersion;Immigrant;improved;Individual;innovation;Institution;interest;Joints;Knowledge;Latino;Latino Population;Leadership;Legal;Measures;meetings;Mentors;Mentorship;Methodology;Michigan;Middle Eastern;Minority;Minority-Serving Institution;Mission;North African;older adult;Outcome;Pathway interactions;Peer Review;Pilot Projects;Politics;Population;Population Research;Process;programs;Publications;Race;Recording of previous events;Records;recruit;Research;Research Personnel;Resources;responsible research conduct;Rotation;Science;Scientist;Series;skills;social;social culture;social disparities;success;symposium;synergism;Underrepresented Populations;United States;United States National Institutes of Health;Universities

PROJECT_TITLE: Research Education Component


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Machine Learning and Artificial Intelligence;Neurosciences;Sleep Research

ORG_CITY: SAINT LOUIS

ORG_DEPT: BIOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE: Sleep is vitally important for brain function and survival, yet its core process remains one of the most poorly understood features of life. We will apply novel methods to reveal generalizable principles about the role of sleep/experience in shaping neural circuits in the brain. In the long term, our results will enhance an understanding of the contribution of sleep to healthy cognition and the mechanisms by which disrupted sleep worsens neurodegenerative and mental health disorders.

PI_NAMEs: HENGEN, KEITH B. (contact)

PROGRAM_OFFICER_NAME: DAVID, KAREN KATE

PROJECT_TERMS: Accounting;Adult;Animal Behavior;Animals;Architecture;artificial neural network;Behavior;Behavior Therapy;Brain;BRAIN initiative;Categories;cell type;Cognition;Cognitive;cognitive benefits;Complex;Darkness;Data;design;Detection;Development;Disease;Environment;experience;experimental study;Future;Goals;Health;Hippocampus;in vivo;information processing;Interneurons;Knowledge;Life;Machine Learning;Measures;Mental disorders;Methodology;Methods;Mission;Modeling;mouse model;Mus;Nerve Degeneration;neural;neural circuit;Neurobiology;Neurons;Neurophysiology - biologic function;Neurosciences;new technology;non rapid eye movement;novel;Process;restoration;Role;Sampling;Shapes;Sleep;Sleep disturbances;Sleep Wake Cycle;statistics;Structure;Synapses;System;Technology;Testing;theories;Time;tool;Variant;Visual System;Work

PROJECT_TITLE: Robust circuit computation in freely behaving animals.


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: PITTSBURGH

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project Narrative Candida auris are major causes of antifungal resistant infections worldwide, which carry high mortality rates. We hypothesize that bloodstream and other invasive infections by C. auris are caused by mixed populations of genetically and phenotypically distinct strains, rather than a single strain as long believed. In this project, we will characterize genetic and phenotypic diversity of C. auris strains recovered from blood cultures of individual patients, and implicate specific genes in antibiotic tolerance and resistance, and in virulence.

PI_NAMEs: NGUYEN, M. HONG THI (contact)

PROGRAM_OFFICER_NAME: LOVE, DONA

PROJECT_TERMS: Adherence;Aneuploidy;anti-fungal agents;Antibiotic Resistance;antibiotic tolerance;biological adaptation to stress;Blood;Blood Circulation;Candida;Candida albicans;Candida auris;Candida glabrata;carbapenem resistance;Cell Wall;Cells;chronic infection;Clinical Microbiology;clinically relevant;clinically significant;Copy Number Polymorphism;Data;Death Rate;Diploidy;Disease Outbreaks;echinocandin resistance;Environment;Exhibits;falls;fitness;Foundations;Fungal Drug Resistance;Gene Dosage;Genes;Genetic;Genetic Determinism;genetic variant;Genetic Variation;Genome;genome sequencing;Genomics;Genotype;Growth;Haploidy;health organization;Hematogenous;Hospitals;In Vitro;Individual;individual patient;Infection;insight;International;Karyotype;Lipase;Microbial Biofilms;Microbial Genetics;Minimum Inhibitory Concentration measurement;Morphogenesis;Morphology;mouse model;Multi-Drug Resistance;mutant;Mutation;Mycoses;neutrophil;novel;Organism;Paper;Pathogenesis;Pathogenicity;Patient Care;Patients;Peptide Hydrolases;Pharmaceutical Preparations;Phenotype;Phylogeny;Point Mutation;Polyploidy;Population;population based;Predisposition;priority pathogen;Process;Production;Public Health;recurrent infection;Regulation;Research Design;Resistance;Resistance development;resistant Klebsiella pneumoniae;response;Sepsis;Single Nucleotide Polymorphism;Site;stem;Sterility;Testing;Treatment Failure;treatment response;Variant;Virulence;whole genome;Yeasts

PROJECT_TITLE: Within-patient Candida auris strain diversity in a tertiary hospital

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AIRT-J(01)]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Aging;Aphasia;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Mental Health;Neurosciences;Rehabilitation;Stroke

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE Stroke is a leading cause of disability in the United States, often leading to acquired language deficits that affects one’s personal and financial wellbeing due to the barriers it places on participation in social and professional activities. Current treatments can promote some limited recovery, but residual disability remains a problem. This research will meet a public health need by investigating whether treatment outcomes can be enhanced with transcranial alternating current stimulation (tACS), an approach that has been successful in promoting rehabilitation from stroke-induced deficits affecting motor processing as well as other neurological and neuropsychiatric disorders.

PI_NAMEs: HARVEY, DENISE Y (contact)

PROGRAM_OFFICER_NAME: RIVERA-RENTAS, ALBERTO L

PROJECT_TERMS: Address;Adult;Affect;Aphasia;aphasia recovery;Basic Science;Behavior Therapy;Behavioral;Biological Markers;Brain;brain dysfunction;Brain region;career development;Cephalic;chronic stroke;clinical investigation;Cognition Disorders;cognitive process;Communication;cost effective intervention;Coupling;Development Plans;disability;effective intervention;Effectiveness;Electric Stimulation;Electroencephalography;Exhibits;Foundations;Frequencies;Functional disorder;Genetic Complementation Test;Goals;Human;Impairment;improved;improved outcome;Individual;innovation;Intervention;Knowledge;Language;language comprehension;Language Development;Language Disorders;language impairment;language processing;Left;Life;Logistics;Measures;Mental disorders;Methodology;Methods;Mission;Motor;motor impairment;Names;Nervous System Disorder;neural;neuromechanism;Neuronal Plasticity;Neurons;neurophysiology;neuropsychiatric disorder;neuroregulation;noninvasive brain stimulation;novel;older adult;Output;Pattern;Performance;Personal Satisfaction;Persons;Placebos;Procedures;Production;programs;Public Health;Quality of life;Recovery;recovery services;Rehabilitation therapy;Research;research and development;Research Personnel;Residual state;Role;Severities;Short-Term Memory;social;specific language impairment;standard of care;Stroke;stroke rehabilitation;stroke survivor;stroke therapy;stroke-induced aphasia;support network;System;targeted treatment;Task Performances;Techniques;Therapeutic;therapy development;Time;tool;Training;translational research program;Treatment outcome;United States;United States National Institutes of Health;Work

PROJECT_TITLE: Transcranial alternating current stimulation to enhance language abilities

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: VEGA, IRVING E (contact)

PROJECT_TERMS: Address;Affect;African American;African American population;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;care providers;Caring;Collaborations;Communities;community clinic;community collaboration;community engagement;Community Health Aides;Community Healthcare;community organizations;Community Outreach;community partners;community partnership;community research;contextual factors;Continuing Education;Country;COVID-19 pandemic;Data Set;Death Rate;Dementia;Development;Directories;Disparity;Education;Education and Outreach;Educational Materials;empowerment;Enrollment;epidemiologic data;Equity;Ethnic Population;Evaluation;experience;Feedback;Fostering;Funding;Goals;Health;health economics;Health education;health equity;Health Personnel;Health Professional;Healthcare Systems;high risk;Immigrant community;Incidence;Individual;Information Dissemination;innovation;Knowledge;Latino;Latino Population;Leadership;Learning;Learning Module;Link;meetings;member;Methods;Michigan;Middle Eastern;Monitor;Newsletter;North African;Not Hispanic or Latino;Outcome;outreach;Participant;Peer Review;Persons;Population;Prevalence;Process;programs;Public Health;Publishing;racial population;recruit;recruitment science;Research;Research Activity;Research Support;Risk Factors;Risk Reduction;Scholarship;Science;Sister;Social Justice;social media;Techniques;Testing;Training;Translations;Underrepresented Populations;underserved community;volunteer;Vulnerable Populations;Work

PROJECT_TITLE: Commumity Liaison and Recruitment Core


NIH_SPENDING_CATS: Neurosciences

ORG_NAME: ALLEN INSTITUTE

ORG_STATE: WA

PHR: Project Narrative The goal of the Scientific and Public Outreach of Cell Type Taxonomies (SPOCTT) initiative is to increase accessibility of brain cell types and taxonomies to the general and scientific communities by improving associated web resources such as tutorials and documentation, supporting cross-consortia collaboration, offering live and webinar training, and supporting educational and general public outreach. This initiative aims to set reference Allen Institute and BICCN taxonomies as industry standards by consolidating and disseminating resources for their standardization, comparison, and exploration. In essence, the SPOCTT initiative will ensure that more people understand and utilize the exciting cell type findings coming from high impact BICCN- and BICAN-funded projects.

PI_NAMEs: CASIMO, KAITLYN ;MILLER, JEREMY A (contact)

PROGRAM_OFFICER_NAME: TRZCINSKI, NATALIE KATHERINE

PROJECT_TERMS: Acceleration;Address;Aging;Applied Research;Area;Atlases;Automobile Driving;base;Brain;brain cell;Brain Diseases;BRAIN initiative;Callithrix;career;Catalogs;Categories;cell type;Cells;Censuses;Classification;Code;Collaborations;college;Communities;community college;computer science;Consensus;Data;data exploration;data integration;Data Set;design;Development;Disease;Disparate;Documentation;Dreams;Education;Educational Curriculum;Educational process of instructing;electrical property;Electrophysiology (science);Ensure;Epigenetic Process;Event;experience;Funding;Future;General Population;Generations;Genes;Genetic;Goals;Health;high school;Human;improved;Individual;Industry Standard;Institution;Internet;Knowledge;Language;Learning;Location;Mammalian Cell;Maps;mathematical sciences;Measurement;Minority;Minority-Serving Institution;Modality;Molecular;Morphology;Motor Cortex;multimodality;Mus;Nature;Neurobiology;Neurons;Neurosciences;Nomenclature;nonhuman primate;online resource;open data;outreach;outreach program;Persons;programs;prospective;Publications;Publishing;real world application;Research;Research Personnel;Resource Sharing;Resources;Science;Scientific Advances and Accomplishments;Series;Shapes;skills;Standardization;Structure;Students;Taxonomy;Testing;Time;tool;Training;transcriptomics;user-friendly;virtual;web app;web-based tool;webinar;Work;Writing

PROJECT_TITLE: Scientific and Public Outreach of Cell Type Taxonomies (SPOCTT) Initiative


PHR: NARRATIVE Aging Asian and Pacific Americans (APAs) face risks for Alzheimer’s disease and related dementias (AD/ADRD), stress from immigration and acculturation, as well as pandemic-related social isolation. The Resource Center for Alzheimer’s and Dementia Research in Asian and Pacific Americans (RCASIA) will identify, mentor, and elevate underrepresented scientists to conduct AD/ADRD-related behavioral, social, and economic research in disaggregated APA populations to improve their brain health, care, and well-being.

PI_NAMEs: HU, WILLIAM TZU-LUNG (contact);WU, BEI

PROGRAM_OFFICER_NAME: RICE, ELISE

PROJECT_TERMS: Acculturation;Adult;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;American;anti-Asian;apprenticeship;Area;Asia;Asian;Asian Americans;Asian Indian;Atherosclerosis;Award;Behavior;Behavioral;Biomedical Research;brain health;career;career development;Career Mobility;Caring;Cause of Death;Chinese;Chinese American;Cities;Cognition;Cognitive;cohort;Cohort Studies;Common Data Element;Communities;community engagement;Complement;Country;COVID-19 pandemic;Data;Data Set;data sharing;Dementia;dementia care;Development;Diagnosis;Discipline;Discrimination;Disparate;Disparity;East Asian;Economics;Education;education research;Effectiveness;Elderly;equity, diversity, and inclusion;Ethnic Origin;Ethnic Population;experience;Face;Faculty;Foundations;Funding;Goals;Growth;Health;health equity;health inequalities;Health Policy;Health Promotion;human old age (65+);Immigration;improved;innovation;insight;Institution;Internships;Knowledge;Language;Lead;Leadership;Learning;Linguistics;Low Prevalence;Measurement;Mediator;Medicare claim;Mentors;Meta-Analysis;method development;Methodology;Methods;metropolitan;Minority;Minority-Serving Institution;Mission;Modeling;multidisciplinary;Native Hawaiian or Other Pacific Islander;New Jersey;New York;New York City;next generation;older adult;Outcome;outreach;pandemic disease;Participant;Peer Review;Personal Satisfaction;Persons;Phase;Pilot Projects;Policy Maker;Population;Population Study;Prevalence;prospective;Prospective Studies;psychosocial;Publications;racial population;racism;Recording of previous events;recruit;Research;Research Personnel;Resources;Scientist;social;social culture;Social isolation;social stigma;South Asian;Stress;Subgroup;success;Surveys;System;Testing;Time;tool

PROJECT_TITLE: Resource Center for Alzheimer's and Dementia Research in Asian and Pacific Americans


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biotechnology;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: FARGO

ORG_NAME: NORTH DAKOTA STATE UNIVERSITY

ORG_STATE: ND

PHR: Stem Cell-Derived Exosomes, MrgD and Vascular Cognitive Impairment in Aging Narrative This proposal tests a novel hypothesis that in aging individuals stem cells interact with blood vessels in the brain via secreting nanovescilces and induce dysfunction, which eventually causes cognitive decline. The proposal furthermore tests if a peptide called Alamandine can reverse dysfunctions induced by aging stem cells and prevent cognitive decline. If carried out successfully, this proposal will provide proof-of-concept for a novel therapeutic target for the treatment of aging- associated cognitive decline.

PI_NAMEs: JARAJAPU, YAGNA  (contact)

PROGRAM_OFFICER_NAME: NEWMAN, ELIZABETH

PROJECT_TERMS: Adult;Affect;Age;age related;age related changes;age-related disease;Aging;aging brain;aging related;Agonist;Agreement;Alzheimer's Disease;angiogenesis;Antioxidants;APP-PS1;Attenuated;Bioenergetics;Blood flow;Blood Vessels;Brain;brain endothelial cell;CD34 gene;Cell Communication;Cells;cerebral microvasculature;cerebrovascular;Cerebrovascular Circulation;Cerebrovascular Disorders;Cerebrovascular system;cognitive function;cognitive performance;Dementia;Development;druggable target;Elderly;endothelial regeneration;Endothelium;Exhibits;exosome;Functional disorder;G-Protein-Coupled Receptors;Glycolysis;hematopoietic stem cell aging;Hematopoietic stem cells;Homeostasis;Human;Impaired cognition;Impairment;in vivo;Individual;Inflammatory;Mediating;Mediator;MicroRNAs;Microvascular Dysfunction;middle age;miRNA expression profiling;Mitochondria;Molecular;Mus;nanosized;nanovesicle;neurovascular coupling;new therapeutic target;novel;old mice;Older Population;Oxidative Phosphorylation;Oxygen;Pathology;Peptides;Persons;pharmacologic;Pharmacology;Phenotype;Play;prevent;receptor;Regulation;Renin-Angiotensin System;response;Risk;Role;senescence;Senility;stem cell aging;stem cell exosomes;stem cells;Testing;transcriptome sequencing;Transgenic Mice;Vascular Cognitive Impairment;vascular cognitive impairment and dementia;Vascular Dementia;Vascular Diseases;Vascular Endothelium;Vesicle

STUDY_SECTION: BINP

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research

PI_NAMEs: HU, WILLIAM TZU-LUNG (contact)

PROJECT_TERMS: Advisory Committees;Age;Alzheimer's Disease;Alzheimer's disease related dementia;American;Area;Asian;Atherosclerosis;Attention;Award;Behavioral;Biomedical Research;career development;Caring;Chinese;Cognition;Cognitive;cohort;Cohort Studies;Collaborations;Collection;Common Data Element;Communication;Communities;conflict resolution;Consultations;Country;Data;data sharing;Dementia;design;Detection;Development;Doctor of Philosophy;Economics;Education;education research;Effectiveness;Ensure;equity, diversity, and inclusion;Ethnic Origin;experience;Faculty;Feedback;Funding;Geography;Goals;Health;health equity;Health Promotion;Home;Immigrant;Immigration;Impaired cognition;improved;innovation;Institution;Language;Lead;Leadership;Linguistics;Mediator;Mentors;Methods;Minority-Serving Institution;Mission;Modeling;Monitor;mosaic;New Jersey;novel;Occupational activity of managing finances;older adult;Outcome;Parents;payment;Persons;Pilot Projects;Population;Process;programs;prospective;recruit;Research;Research Personnel;Resources;Role;Science;Scientist;Secure;senior faculty;social;Social Network;Sorbus;sound;South Asian;Subgroup;success;Testing;Time;tool;Training Programs;United States National Institutes of Health;Universities;Work


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: CRYSTAL, STEPHEN  (contact)

PROJECT_TERMS: Address;Affect;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;American;analytical method;Archives;Area;Asian;Behavioral;behavioral health intervention;Biomedical Research;brain health;Caring;Catalogs;Chinese;Clinical Research;Cognition;cohort;Collection;Common Data Element;Communities;community partners;Community Surveys;Data;Data Analyses;data harmonization;data resource;Data Set;Dementia;design;Development;Disadvantaged;Discipline;Disparity;Doctor of Philosophy;economic determinant;Economics;Educational process of instructing;Elderly;equity, diversity, and inclusion;ethnic disparity;Evaluation;Evidence based intervention;experience;Faculty;Funding;Future;genomic data;Goals;Health and Retirement Study;health determinants;health disparity;health inequalities;Health Services;Health Services Research;Health Surveys;Influentials;Infrastructure;innovation;instrument;intergenerational;Investigation;late life;Life Cycle Stages;Linguistics;Link;Measurement;Measures;Medicare;meetings;Mentors;method development;Methodology;Mission;Modeling;next generation;novel;older adult;Online Systems;Outcome;Pilot Projects;Population;Population Study;Probability;programs;Public Health;Qualitative Research;racial disparity;Reduce health disparities;Registries;Reporting;repository;Reproducibility;Research;research and development;Research Design;Research Infrastructure;Research Methodology;Research Personnel;Research Support;Resources;response;Science;Scientist;social;Sociology;Statistical Models;Strategic Planning;Subgroup;Surveys;System;Testing;theories;tool;Training;United States National Institutes of Health;webinar;Work

PROJECT_TITLE: Analytical Core


PI_NAMEs: MITTELMAN, MARY SHERMAN (contact)

PROJECT_TERMS: acceptability and feasibility;Adult;Alzheimer's Disease;Alzheimer's disease related dementia;American;apprenticeship;Asian;Asian Americans;Asian Indian;Atherosclerosis;Award;Behavioral;Biomedical Research;brain health;care delivery;career;Caring;China;Chinese;Chinese American;Clinical Sciences;Cognition;Cognitive;cohort;Cohort Studies;Collaborations;Common Data Element;Communities;comorbidity;concept mapping;Consultations;contextual factors;Continuous Glucose Monitor;Data;Dementia;design;Detection;Development;Diabetes Mellitus;didactic education;Discipline;Economics;Education;education research;Educational workshop;Effectiveness;Elderly;Epilepsy;Ethics;Ethnic Origin;Evaluation;experience;Faculty;Feedback;Funding;Funding Mechanisms;Goals;Grant;Health;health care service utilization;health equity;Health Promotion;Immigrant;Immigration;implementation evaluation;improved;Infrastructure;innovation;Joints;Language;Lead;Linguistics;Measures;Mediator;meetings;member;Mentors;Methodology;Methods;Minority-Serving Institution;Mission;Modeling;Monitor;mosaic;Needs Assessment;New Jersey;older adult;Participant;peer coaching;Peer Review;Persons;Pilot Projects;Population;Population Study;Process;Productivity;prospective;psychosocial;Publications;recruit;Research;Research Personnel;Resources;responsible research conduct;Science;Scientist;social;social determinants;South Asian;Structure;Subgroup;success;Testing;theories;Time;tool;Training;Training Activity;Translational Research;Universities;Work

PROJECT_TITLE: Research Education Core


NIH_SPENDING_CATS: Aging;Atherosclerosis;Basic Behavioral and Social Science;Behavioral and Social Science;Cardiovascular;Clinical Research;Heart Disease;Heart Disease - Coronary Heart Disease;Palliative Care

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: PROJECT NARRATIVE Nuclear stress imaging is a common test ordered for older patients presenting with symptoms of ischemic heart disease (e.g., chest pain or dyspnea), however the results of the stress test often do not lead to evidence-based changes in treatment for older patients. In the current study, we aim to understand older adults and caregiver perspectives on how they make treatment decisions after a stress test, whether age-related impairments in function or cognition would affect their decision making and identify which outcomes are most valuable for them; and study how physicians currently incorporate these factors and the imaging test result into treatment plans and how choice of treatment affects patient outcomes. The results of this study will be used to develop decision aids to help older patients make decisions regarding stress testing and choose treatments which can improve outcomes they most care about.

PI_NAMEs: PATEL, KRISHNA KAUSHIK (contact)

PROGRAM_OFFICER_NAME: SERRA, MONICA CHRISTINE

PROJECT_TERMS: Acceleration;Affect;Age;age related;Age Years;age-related disease;Aging;Area;Attitude;Award;Cardiac;cardiovascular imaging;Cardiovascular system;care costs;Caregivers;Caring;Characteristics;Chest Pain;Chronology;Clinical;Cognition;Coronary Arteriosclerosis;Data;Decision Aid;Decision Making;Development;Diagnosis;Diagnostic;Dyspnea;Elderly;empowerment;Evaluation;evidence base;Focus Groups;Foundations;frailty;functional status;Funding;Future;Geriatric Assessment;Geriatrics;Goals;Grant;Group Interviews;Health system;Image;Impaired cognition;Impairment;improved;improved outcome;Interview;Ischemia;Medical;Mentors;Mentorship;multidisciplinary;multiple chronic conditions;Myocardial Ischemia;Nuclear;nuclear imaging;older adult;older patient;Outcome;Patient Outcomes Assessments;Patient-Focused Outcomes;Patients;personalized decision;personalized risk prediction;Pharmaceutical Preparations;Physicians;Population;preference;Probability;Qualitative Research;Quality of life;Registries;Reporting;Research;Research Personnel;revascularization;Risk;Risk Factors;risk prediction model;Role;shared decision making;Stress;Stress Tests;Structure;symptom treatment;Symptoms;Test Result;Testing;Thinking;Training;treatment choice;treatment planning;treatment strategy;Work

PROJECT_TITLE: Re-thinking the Role of Stress Imaging for Symptomatic Older Adults with Stable Coronary Artery Disease


PI_NAMEs: YANG, CUI  (contact)

PROJECT_TERMS: Adult;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;American;Area;Asian;Behavioral;Biomedical Research;brain health;Caring;Cognition;cognitive disability;Committee Membership;Common Data Element;Communities;community engaged research;community engagement;community organizations;community partners;crowdsourcing;Data;Dementia;Development;Disparity;Doctor of Philosophy;Economics;Educational workshop;Enrollment;Environment;Equity;equity, diversity, and inclusion;Ethnic Origin;Ethnic Population;experience;Fostering;functional disability;Funding;Generations;Goals;Health;health disparity;High Prevalence;improved;Infrastructure;innovation;Institution;Internships;Knowledge;Language;Linguistics;Low income;member;Mentors;minority engagement;Minority Groups;Minority-Serving Institution;Mission;Modeling;National Institute on Minority Health and Health Disparities;Not Hispanic or Latino;older adult;Oral health;Outcome;Parents;Persons;physically handicapped;Pilot Projects;Play;Population;Poverty;racial population;recruit;Research;Research Personnel;Research Training;Resources;Role;Rotation;Scientist;Series;social;Socioeconomic Status;Subgroup;Testing;tool;Training;Training Activity;United States National Institutes of Health;volunteer;Workforce Development

PROJECT_TITLE: Community Liaison and Recruitment Core


ADMINISTERING_IC: EB

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: DAVIS

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Narrative The exploding field of radio-theranostics makes nuclear imaging a central tool and redefines its performance requirements. Nuclear imaging technology is undergoing a paradigm shift focusing on utilizing timing information to enable a leap in image quality. Biomedical researchers need new simulation and experimental tools to develop these fast radiation detectors, which this project proposes to develop and apply with AI-based optical simulation software.

PI_NAMEs: RONCALI, EMILIE  (contact)

PROGRAM_OFFICER_NAME: TORNAI, MARTIN PAUL

PROJECT_TERMS: Acceleration;Address;Affect;Algorithms;Automobile Driving;Clinical;Collaborations;Collection;commercialization;Communities;Consumption;Custom;Data;deep learning;design;detector;Development;Dimensions;Discipline of Nuclear Medicine;Event;Explosion;Family;generative adversarial network;Geometry;Grant;high energy physics;Image;Image Analysis;Imaging technology;improved;Individual;innovation;International;Ionizing radiation;learning materials;Light;Methodology;Methods;Modeling;Monte Carlo Method;nanophotonic;Nanostructures;Nature;next generation;Noise;novel;nuclear imaging;open data;Optics;particle;Performance;photonics;Photons;Physics;Positron-Emission Tomography;Process;Production;Pythons;radiation detector;Radio;reconstruction;Research;Research Personnel;Resolution;Signal Transduction;simulation;simulation software;single photon emission computed tomography;Speed;Structure;System;Technology;technology development;theranostics;Time;tool;Training;United States National Institutes of Health;Work

PROJECT_TITLE: AI-accelerated optical simulation for fast timing nuclear imaging

STUDY_SECTION: ITD

STUDY_SECTION_NAME: Imaging Technology Development Study Section[ITD]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Aging;Arthritis;Behavioral and Social Science;Biomedical Imaging;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Machine Learning and Artificial Intelligence;Mental Health;Neurosciences;Osteoarthritis;Pain Research;Precision Medicine;Prevention

ORG_DEPT: PHYSICAL MEDICINE & REHAB

PHR: Project Narrative We propose a mechanistic prospective study to define biomarkers that differentiate the pain response in OA patients to naproxen, duloxetine and placebo, three agents with different mechanisms and sites of action. With this information, we will define responder phenotypes for each of these agents which will then allow for personalized medicine, providing the therapeutic intervention most likely to be effective for relief of pain, thus also reducing the risks of exposure to non-effective treatments.

PI_NAMEs: APKARIAN, APKAR VANIA;GRIFFITH, JAMES WILLIAM;SCHNITZER, THOMAS JACK (contact)

PROGRAM_OFFICER_NAME: ZHENG, XINCHENG

PROJECT_TERMS: Aftercare;Age;Anatomy;Anxiety;arm;Attention;Back;Behavioral;Biochemical;Biological Markers;Blinded;Brain;brain based;brain circuitry;Brain imaging;C-reactive protein;Caring;central sensitization;Characteristics;chronic pain;Clinic;Clinical;clinical biomarkers;Clinical Data;clinical outcome measures;clinical phenotype;Clinical Trials;Collection;conditioning;cost effective;daily pain;Data;Degenerative polyarthritis;demographics;design;Development;Disease;duloxetine;Emotional;emotional functioning;epidemiology study;Etiology;Exposure to;Formulation;Funding Opportunities;Future;Goals;Image;improved;indexing;Individual;individual patient;individual variation;Inflammation;inhibitor;innovation;Intervention;Joints;Knee;Knee Osteoarthritis;machine learning prediction;Magnetic Resonance Imaging;Measures;Mental Depression;Modality;model generalizability;Modeling;Naproxen;neurosensory;Nociception;Non-Steroidal Anti-Inflammatory Agents;Norepinephrine;novel therapeutics;opioid use;osteoarthritis pain;Pain;Pain intensity;pain perception;pain relief;Parents;Participant;Pathway interactions;patient oriented;Patient Outcomes Assessments;patient response;Patient risk;Patient Selection;patient variability;Patients;Peripheral;Personality;personalized medicine;Persons;Pharmaceutical Preparations;pharmacologic;Pharmacotherapy;Phenotype;Physiological;Placebo Effect;Placebos;predictive modeling;prognostic;Prognostic Factor;Prognostic Marker;prognostication;Property;prospective;Prospective Studies;psychologic;Psychological Factors;Psychometrics;Questionnaires;radiological imaging;Randomized;randomized trial;Randomized, Controlled Trials;research clinical testing;Research Project Grants;response;response biomarker;reuptake;Risk;Sensory;Serotonin;Serum;sex;side effect;Site;specific biomarkers;Specificity;Spinal Cord;success;Testing;Therapeutic;Therapeutic Agents;Therapeutic Intervention;treatment response;Validation;Work

PROJECT_TITLE: Brain-based and clinical phenotyping of pain pharmacotherapy in knee OA

STUDY_SECTION: AIMR

STUDY_SECTION_NAME:
Aging, Injury, Musculoskeletal, and Rheumatologic Disorders Study
Section[AIMR]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Coronaviruses;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Lung;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Project Narrative: Development of effective vaccines is the time-tested approach for controlling infectious diseases. The proposed work will improve mouse models of human immunity to vaccines and has the potential to develop vaccines that stimulate potent immunity to influenza virus and SARS-CoV-2. The findings from the proposed work are expected to have broad implications in the development of vaccines against respiratory viruses of humans.

PI_NAMEs: SURESH, MARULASIDDAPPA  (contact)

PROGRAM_OFFICER_NAME: MALLIA, CONRAD M

PROJECT_TERMS: 2019-nCoV;Adjuvant;Agonist;Animal Model;Antibodies;Antigens;antiviral immunity;Biomedical Research;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Count;Cells;Cessation of life;clinical practice;Communicable Diseases;conditioning;COVID-19 vaccine;Cytoprotection;Data;Development;effector T cell;efficacy study;Epithelium;Epitopes;experience;Exposure to;Formulation;Genetic;Genetic Transcription;germ free condition;Goals;Granzyme;Growth;Hemagglutinin;Human;human model;human pathogen;Immune response;immune system function;Immunity;Immunologics;improved;Inbred Mouse;Inbreeding;Infection;Influenza;Influenza A virus;influenza A virus nucleoprotein;influenza virus strain;influenza virus vaccine;influenzavirus;innovation;insight;interest;Intranasal Administration;Investigation;Learning;Link;Lipid A;Lung;Lymphoid;Membrane Proteins;Memory;Microbe;microbial;microbial community;microbiome composition;microbiota;Molecular;mouse model;mucosal vaccine;Mucous Membrane;Mus;Mutation;nanoemulsion;Neuraminidase;novel;Nucleoproteins;pandemic influenza;pre-clinical;preconditioning;protective efficacy;Proteins;Public Health;pulmonary function;Research;Resolution;respiratory pathogen;Respiratory System;Respiratory Tract Infections;respiratory virus;response;Seasons;Seminal;Site;Spleen;Structure of parenchyma of lung;Subunit Vaccines;Surface;T cell response;T-Lymphocyte;Testing;Time;Tissue Differentiation;tissue resident memory T cell;Tissues;TLR4 gene;Translating;Vaccinated;Vaccination;vaccine development;vaccine efficacy;vaccine formulation;vaccine immunogenicity;Vaccine Research;Vaccines;Variant;Viral;Viral Respiratory Tract Infection;Virus Diseases;Work

PROJECT_TITLE: Vaccine-Induced Mucosal T-Cell Immunity to Respiratory Viruses in Dirty Mice

STUDY_SECTION: VID

STUDY_SECTION_NAME: Vaccines Against Infectious Diseases Study Section[VID]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: Project Narrative Although young adult-born neurons (ABNs) have been shown to play an important role in memory and emotion processing under physiological conditions, their function and therapeutic potential in degenerated AD brains remain largely undefined. Our recent study showed activation of a small population of SuM-enhanced ABNs is sufficient to restore memory and reduce anxiety/depression-like behaviors in AD mice. This proposal aims to decipher the mechanisms underlying these beneficial effects using two complementary AD mouse models.

PI_NAMEs: SONG, JUAN  (contact)

PROGRAM_OFFICER_NAME: SUTTERER, MATTHEW

PROJECT_TERMS: Acute;Adult;Affective;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease pathology;Alzheimer's disease patient;Anatomy;Animal Diseases;Anxiety;anxiety reduction;anxiety-like behavior;awake;Behavior;behavior test;Behavioral;Brain;brain dysfunction;Cell Nucleus;Chronic;Cognitive;confocal imaging;Development;Electrophysiology (science);Emotions;Exhibits;Fiber;Functional Magnetic Resonance Imaging;functional restoration;Genetic;granule cell;Health;Hippocampus;Hypothalamic structure;Image;Impairment;improved;in vivo;Knock-in;Knowledge;Mediating;Memory;Memory Loss;Mental Depression;Microglia;Molecular;mouse model;Mus;Nature;neurogenesis;neuroinflammation;Neurons;Neurosciences;novel therapeutic intervention;optogenetics;overexpression;Pathway interactions;Pattern;Performance;Phagocytosis;Phosphoproteins;phosphoproteomics;Photometry;Physiological;Play;Population;Production;Property;Proteomics;receptor;Recovery of Function;Role;Slice;Testing;Therapeutic;Wild Type Mouse;young adult

PROJECT_TITLE: Enhancing adult-born neurons to restore brain functions in Alzheimer's disease

STUDY_SECTION: CDIN

STUDY_SECTION_NAME: Chronic Dysfunction and Integrative Neurodegeneration Study Section[CDIN]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: CLEVELAND

ORG_NAME: CLEVELAND STATE UNIVERSITY

ORG_STATE: OH

PHR: Host cells play an important role in virus infection. When the SARS-CoV-2 virus infects lung cells, then the activities of lung cells cause the inhibition of synthesis of two viral proteins, e.g., ORF1a and spike protein. This proposal wants to uncover the mechanistic insights of this process.

PI_NAMEs: MAZUMDER, BARSANJIT  (contact)

PROGRAM_OFFICER_NAME: PLIMACK, MARY KATHERINE BRADFORD

PROJECT_TERMS: 2019-nCoV;3' Untranslated Regions;Adopted;Affinity Chromatography;Binding;Biochemical;Cells;chemokine;chemokine receptor;Complement;complement system;Complex;Coronavirus;DAP kinase;Development;Elements;Foundations;Gastroenteritis;Gel Chromatography;Genes;genetic information;Genome;genomic RNA;Human;Infection;Inflammation;Inflammatory;inhibitor;Innate Immune Response;insight;Interferon Type II;Intervention;Journals;kinase inhibitor;Laboratories;Lentivirus;Lung;Macrophage;Mass Spectrum Analysis;Mediating;member;Messenger RNA;Modeling;Molecular Sieve Chromatography;monocyte;Mutation;Myeloid Cells;Names;next generation;novel;Nucleic Acids;Phosphorylation;Phosphotransferases;Physiological;Play;Process;Proteins;Publishing;Recombinants;Replicon;respiratory pathogen;Respiratory syncytial virus;response;Ribonucleoproteins;Ribosomal Proteins;Ribosomes;RNA;RNA Binding;RNA Folding;RNA vaccine;RNA Viruses;RNA-Binding Proteins;Role;SARS-CoV-2 genome;SARS-CoV-2 infection;SARS-CoV-2 spike protein;Series;Signal Induction;Signal Transduction;Small Interfering RNA;small molecule;small molecule inhibitor;System;Testing;Translational Regulation;Translational Repression;Translations;upstream kinase;viral fitness;viral genomics;Viral Proteins;viral RNA;virology;Virulence;Virus;Virus Diseases;virus host interaction;Virus-like particle;Work

PROJECT_TITLE: Translational Regulation of SARS-CoV-2 in response to viral S protein-induced signaling

STUDY_SECTION: VPI

STUDY_SECTION_NAME: Viral Pathogenesis and Immunity Study Section [VPI]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Cardiovascular;Cerebrovascular;Dementia;Genetics;Heart Disease;Neurodegenerative;Neurosciences;Prevention;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: PROJECT NARRATIVE The proposed work aims to investigate the temporal relationships between mtDNA alterations and midlife brain health. This study will also examine childhood risk factors preceding mitochondrial dysfunction. Knowledge gained from this study may contribute important insights into the biology underlying brain health and provide novel strategies for the targeted prevention of mitochondrial dysfunction and its brain health sequelae.

PI_NAMEs: PAN, YANG  (contact)

PROGRAM_OFFICER_NAME: MARTIN, DAMALI

PROJECT_TERMS: Acceleration;Adult;Affect;Aging;aging brain;aging related;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease model;Amyloid;apolipoprotein E-4;Articulation;Award;Bioenergetics;Biology;Black Populations;Blood;Blood Pressure;Body mass index;Brain;brain health;brain magnetic resonance imaging;brain research;brain tissue;Cardiac health;cardiometabolism;cardiovascular disorder risk;career;Cephalic;Cerebrovascular Circulation;Cerebrum;Childhood;Clinical;Cognition;cognitive function;Cohort Studies;Data;Dementia;Development;Diagnosis;DNA copy number;drug development;early detection biomarkers;Early Diagnosis;effective therapy;epidemiologic data;Epidemiology;follow-up;Functional disorder;Functional Magnetic Resonance Imaging;Funding;genome wide association study;Genomics;Genotype;global health;Glucose;Growth;Health;health data;Heart;heteroplasmy;Homeostasis;Impaired cognition;improved;innovation;insight;Knowledge;Life;Life Cycle Stages;Linear Regressions;Link;Lipids;Measurement;Measures;Mediating;Mediation;Mendelian randomization;Mentors;Meta-Analysis;Methods;middle age;Mitochondria;Mitochondrial DNA;mitochondrial DNA alteration;mitochondrial DNA mutation;mitochondrial dysfunction;Modeling;Molecular;multiple omics;Mutation;Neurobiology;neurocognitive test;novel marker;novel strategies;older adult;Organ;Participant;Photons;Play;Population;Prevalence;prevent;Prevention;preventive intervention;programs;prospective;Renal function;Research;Resources;Risk Factors;risk stratification;Role;Sampling;Scanning;statistics;Syndrome;Testing;Time;tomography;tool;Training;Trans-Omics for Precision Medicine;United States National Institutes of Health;Validation;Variant;White Matter Hyperintensity;Work

PROJECT_TITLE: Associations of Mitochondrial DNA Alterations with Alzheimer's Disease Related Brain Health

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development Facilitating The Transition to Independence Study Section[AGCD-1]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cardiovascular;Clinical Research;Heart Disease;Heart Disease - Coronary Heart Disease;Machine Learning and Artificial Intelligence

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

PHR: Project Narrative  This project is to develop and validate a new cardiac magnetic resonance imaging method to measure the amount of oxygen extracted from the blood into the heart. We will validate this new noninvasive artificial intelligence-assisted imaging method, which requires no intravenous contrast, by comparing it with information obtained from invasive catheter-based measurements in preclinical models. We will also compare our new technique to Positron Emission Tomography (PET), a standard nuclear imaging technique, in patients with heart disease.

PI_NAMEs: WOODARD, PAMELA K;ZHENG, JIE  (contact)

PROGRAM_OFFICER_NAME: HALLER, JOHN WAYNE

PROJECT_TERMS: Acetates;Affect;Animal Model;Area;Artificial Intelligence;Biological;Blood;Blood flow;Blood Volume;canine model;Canis familiaris;Cardiac;cardiac magnetic resonance imaging;Cardiomyopathies;cardioprotection;Cardiovascular system;Catheters;Cell Respiration;Clinical;clinical application;cohort;Compensation;Consumption;Contrast Media;Coronary Arteriosclerosis;Coronary sinus structure;Coronary Stenosis;cost;Coupled;Coupling;Data Analyses;deep learning;deep learning model;Defect;Dependence;Detection;detection method;Development;Diagnosis;Dilated Cardiomyopathy;Drops;Early Diagnosis;Equation;Equilibrium;Evaluation;Exercise;fluorodeoxyglucose;fluorodeoxyglucose positron emission tomography;Functional disorder;glucose uptake;healthy volunteer;Heart;Heart Diseases;Heart failure;Heart Valve Diseases;Human Volunteers;Hyperemia;Hypertrophic Cardiomyopathy;Image;imaging modality;Imaging Techniques;improved;in vivo;Injury;Intervention;Intravenous;Ionizing radiation;Ischemia;ischemic cardiomyopathy;magnetic field;Magnetic Resonance;Magnetic Resonance Imaging;Maps;Measurement;Measures;Mechanics;Metabolic;Metabolic dysfunction;Metabolism;Methods;Monitor;Morphologic artifacts;Muscle Cells;Myocardial;Myocardial Infarction;Myocardial Ischemia;Myocardial perfusion;Myocardial tissue;Myocardium;Noise;novel;novel therapeutic intervention;nuclear imaging;Oxygen;Oxygen Consumption;Pathologic;Pathology;Patient Selection;Patients;Perfusion;pharmacologic;Phase;Physiological;Positron-Emission Tomography;pre-clinical;Pre-Clinical Model;preservation;Principal Investigator;Recovery of Function;Reperfusion Therapy;Residual state;Resolution;Rest;Sampling;Seminal;septic;Signal Transduction;Stimulus;Structural defect;System;Techniques;Testing;Time;Tissues;tool;uptake;Validation;validation studies;Vasodilation;Ventricular;Water;Work

PROJECT_TITLE: Validation of Myocardial Oxygen Extraction Fraction Measurement with MRI

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Biomedical Imaging;Brain Disorders;Clinical Research;Mental Health;Neurosciences;Substance Misuse

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative Completely noninvasive neuromodulation using transcranial ultrasound stimulation (TUS) offers the promise of precisely stimulating specific targets deep in the brain, such as the nucleus accumbens for substance abuse disorders, at low and safe power levels commonly used for diagnostic imaging studies. However, a current concern in the use of TUS in human studies is the potential for an auditory effect to confound the results, especially in studies susceptible to the placebo effect or attention effects. The purpose of this proposed research is to enable more rigorous, and therefore successful, TUS studies for the treatment of SUDs and other neurological disorders.

PI_NAMEs: BUTTS-PAULY, KIM  (contact)

PROGRAM_OFFICER_NAME: ALVAREZ, RUBEN PAUL

PROJECT_TERMS: Acoustic Stimulation;Acoustics;Affect;aged;Air;Animal Model;Attention;Auditory;Auditory system;behavior measurement;Behavioral;behavioral response;bone;bone visualization;Brain;Brain region;brain stem auditory evoked potentials;brain tissue;Cephalic;Clinical Trials;Cochlea;Code;cranium;Data;Data Set;design;Diagnostic Imaging;Disease;Dose;Earplug;Environment;Epilepsy;experimental study;flexibility;Frequencies;Hearing;Human;Image;imaging study;improved;Individual;innovation;Intervention;Investigation;Labyrinth;Location;Loudness;Magnetic Resonance Imaging;Masks;Measurement;Measures;Mental Depression;Mental Health;Methods;Monitor;Morphology;Nervous System Disorder;Neurologic;neuroregulation;Noise;noninvasive brain stimulation;Nucleus Accumbens;open source;Outcome;Persons;Phase;Physiologic pulse;Physiological;Placebo Effect;Placebos;Porosity;pre-clinical;Predisposition;Preparation;pressure;Procedures;prospective;Psychophysics;Qualifying;Radiation;Research;Research Personnel;Resolution;response;Rodent;Safety;Science;Signal Transduction;Site;skull base;Slice;Sonication;sound;Substance abuse problem;Substance Use Disorder;substance use treatment;success;System;Technology;Temporal bone structure;Testing;Thick;Time;Tremor;ultrasound;vibration;viscoelasticity;Work

PROJECT_TITLE: Step 1 in Designing Appropriate Shams and Controls in Human TUS

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-NV-Q(91)S]


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Hematology;Maternal Health;Maternal Morbidity and Mortality;Pain Research;Pregnancy;Rare Diseases;Sickle Cell Disease;Women's Health Research

ORG_CITY: ACCRA

ORG_COUNTRY: GHANA

ORG_FIPS: GH

ORG_NAME: COLLEGE OF HEALTH SCIENCES, UNIVERSITY OF GHANA

PHR: Project Narrative Pregnancy in sickle cell disease (SCD) is a life-threatening complication associated with 23-fold increased odds of maternal death and a maternal mortality ratio of 2,393 and approximately 4,300 deaths per 100,000 live births with and without multidisciplinary care in low and middle-income countries; compared to the general maternal mortality rate of approximately 23.8 and 8 deaths per 100,000 live births in the USA and Northern Europe, respectively. In Ghana, a multidisciplinary SCD obstetrics program at an academic hospital reported a dramatic reduction in maternal and perinatal mortality rates; unfortunately, this academic facility caters to less than 20% of pregnant women with SCD in the Greater Accra Region. This mentored award is focused on initiating a hybrid type 1 study for multidisciplinary SCD obstetrics care program in a resource-limited non- academic hospital, a strategy that is expected to decrease maternal mortality in women with SCD.

PI_NAMEs: ASARE, EUGENIA VICKY (contact)

PROGRAM_OFFICER_NAME: HAYES, UNJA

PROJECT_TERMS: acute chest syndrome;Acute Pain;adjudication;Africa;Africa South of the Sahara;Award;Caring;Case Series;Cause of Death;Certification;Cessation of life;Clinic;Clinical;cohort;Communication;compare effectiveness;Complication;Consolidated Framework for Implementation Research;Data Collection;Death Rate;Diagnosis;Discipline of obstetrics;Education;evidence base;Evidence based practice;experience;Failure;Feasibility Studies;Fetal Monitoring;Focus Groups;Future;General Practitioners;Ghana;Goals;Guidelines;Health Personnel;Hematologist;Hematology;Hospital Administrators;hospital care;Hospitals;hybrid type 1 study;Hybrids;implementation process;implementation/effectiveness;improved;Institution;Intervention;Interview;Joints;Knowledge;Laboratory Scientists;Life;Life Expectancy;Live Birth;Location;low and middle-income countries;maternal morbidity;Maternal Mortality;Medical;Mentors;Midwife;multidisciplinary;Needs Assessment;Northern Europe;obstetric care;Odds Ratio;pediatrician;Perception;perinatal morbidity;Perinatal mortality demographics;Physicians;Pilot Projects;Pregnancy;Pregnant Women;prevent;programs;prospective;Protocols documentation;Provider;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Relative Risks;Reporting;Research Design;Resource-limited setting;Resources;Risk Reduction;Scientist;Series;service delivery;Sickle Cell Anemia;Site;skill acquisition;Structure;System;Teaching Hospitals;Technology;tertiary care;Testing;Training and Education;Woman;Women's mortality;Work

PROJECT_TITLE: Multidisciplinary sickle cell disease obstetrics care program in Ghana: Non-academic vs.Academic Hospital (Pilot Study)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ICP-J(55)R]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;HIV/AIDS;Infectious Diseases;Prevention;Stroke

ORG_CITY: Stellenbosch

ORG_COUNTRY: SOUTH AFRICA

ORG_FIPS: SF

ORG_NAME: STELLENBOSCH UNIVERSITY

PHR: PROJECT NARRATIVE The risk for stroke is two-fold higher in people with HIV (PWH) compared to people without HIV, despite antiretroviral therapy (ART) and viral suppression, and without many of the traditional stroke risk factors, suggesting ongoing HIV-associated inflammation as a potential driver of stroke risk. Adherence to ART sufficient to suppress viral loads to below the clinically-relevant threshold of 200 copies/mL may not be adequate to suppress viremia completely, with ongoing HIV-associated inflammation. We will conduct a comparative observational study in virally suppressed PWH presenting with stroke compared to PWH without stroke to obtain preliminary, exploratory data on the association between stroke and imperfect adherence to ART, viremia and the viral reservoir, and exploratory proteomic biomarkers.

PI_NAMEs: DECLOEDT, ERIC HERMANN (contact);ORRELL, CATHERINE

PROGRAM_OFFICER_NAME: BANSAL, GEETHA PARTHASARATHY

PROJECT_TERMS: acute stroke;Adherence;adherence rate;Africa South of the Sahara;Age;Anti-Retroviral Agents;antiretroviral therapy;Automobile Driving;Basal Ganglia;Biological Assay;Biological Markers;biomarker performance;Blood;Blood specimen;Blood Vessels;candidate identification;candidate marker;cardiovascular risk factor;Cardiovascular system;Case/Control Studies;Categories;Classification;Clinical;clinical practice;clinically relevant;cohort;Cohort Studies;comparative;Confidence Intervals;Country;Data;detection limit;Diphosphates;Disease;Dryness;Economic Burden;Event;Female;follow-up;forgiveness;Future;Health;health care economics;HIV;immune reconstitution;Income;Inflammation;Inflammatory;Inflammatory Response;insight;Ischemic Stroke;Knowledge;Matched Group;Measures;men;Morbidity - disease rate;mortality;multiplex assay;novel strategies;Observational Study;Odds Ratio;Outcome;Participant;Persons;Pharmaceutical Preparations;pill;Plasma;Population;Population Control;Premature aging syndrome;Prevalence;prospective;proteomic signature;Proteomics;Regimen;Research;Research Personnel;Residual state;Risk;Risk Factors;Serum;South Africa;South African;Spottings;standard of care;Stroke;stroke risk;success;systematic review;Tenofovir;Testing;therapy adherence;Time;Uganda;Viral;Viral Load result;Viral reservoir;Viremia;Virus Latency;Virus Replication

PROJECT_TITLE: Antiretroviral therapy adherence and exploratory proteomics in virally suppressed people with HIV and stroke

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Social Determinants of Health

ORG_CITY: SAN JUAN

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF PUERTO RICO MED SCIENCES

ORG_STATE: PR

PHR: Project Narrative Aging is accompanied by changes at the organ as well as at the systemic level; one hallmark of aging is decline in immune function and increases in inflammation that hinder the immune response. Because there is great heterogeneity in aging trajectories, there is a need to understand what factors cause certain individuals to age faster, and in recent years research has shown that the social environment may affect the pace of aging. By using a non-human primate model that has similar aging trajectories to humans, this project will investigate if and how accumulation of social adversity may induce aging-related changes in immunity (both at baseline and in response to a stimulation), making social adversity a key component in the development of aging-related diseases and a possible target of behavioral interventions to prevent or mitigate them.

PI_NAMEs: SANCHEZ-ROSADO, MITCHELL  (contact)

PROGRAM_OFFICER_NAME: MORO, MANUEL H

PROJECT_TERMS: Acceleration;Acute;adaptive immune response;Affect;Age;age acceleration;age effect;age related changes;age related decline;age-related disease;Aging;aging population;aging process;aging related;aging related disease;Animals;Anti-Inflammatory Agents;Arthritis;Autoimmune Diseases;Bacteria;Bacterial Infections;behavior observation;Behavior Therapy;Biological;Blood specimen;Cardiovascular Diseases;Cell Physiology;Cell Surface Receptors;cell type;Cells;Cessation of life;Chronology;cytokine;Data;Demographic Factors;Development;Dexamethasone;Disease Progression;Down-Regulation;Elderly;Environment;Equilibrium;Escherichia coli;experience;experimental study;Exposure to;falls;Fasciola hepatica;Flow Cytometry;Gene Expression Regulation;Genetic;Glucocorticoids;hallmarks of aging;Health;Helminths;Heterogeneity;Human;human model;hypertensive;Immune;immune function;Immune response;Immune system;Immune Tolerance;Immunity;Immunologic Stimulation;immunological status;Immunologics;immunosenescence;Impaired cognition;Impairment;In Vitro;Individual;Infection;Infection Control;Inflammation;Inflammatory;Innate Immune Response;Intervention;Laboratories;Life Cycle Stages;life span;Lipopolysaccharides;Livestock;Longitudinal Studies;Lymphocyte;Macaca;Macaca mulatta;Measures;microbial;Modeling;Molecular;molecular marker;Monkeys;monocyte;mortality;nonhuman primate;Older Population;Organ;Parasites;pathogen;Pathway interactions;peer;Peripheral;Peripheral Blood Mononuclear Cell;Persons;Phylogenetic Analysis;Physiological;Play;polarized cell;Population;Prevalence;prevent;Production;rate of aging;receptor expression;Regulation;Research;Research Project Grants;Resources;response;Role;Route;Sample Size;self organization;Series;Shapes;social;social adversity;social determinants;Social Development;Social Environment;social group;social integration;Social status;social structure;survival outcome;T-Lymphocyte;Testing;transcriptome sequencing;Variant;Virus;Zika Virus

PROJECT_TITLE: Effects of age and social adversity on immune status and responsiveness in a non-human primate model of human aging

STUDY_SECTION_NAME: Career Development for Established Investigators and Conference Grants Study Section[AGCD-4]


ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: Overall Project Narrative  Given the health crisis presented by neurological conditions that develop as we age, it's important to understand the mechanisms underlying both normal and pathological cognitive change in order to develop scalable, evidence-based prevention and intervention strategies. This project will support the expansion, use, and widespread dissemination of the Mobile Toolbox Research Platform, an adaptable, open-source research ecosystem to enable remote smartphone-based cognitive and behavioral assessment. The ability to easily collect and share a broad spectrum of data from large and diverse participant samples can substantially improve aging research methods, have a meaningful impact on clinical outcomes, and ultimately improve the lives of older adults and their families.

PI_NAMEs: GERSHON, RICHARD  (contact)

PROGRAM_OFFICER_NAME: TREVINO, MELISSA

PROJECT_TERMS: Address;Adopted;Adult;Affect;Age;age stratification;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Android;base;Behavior;Behavior assessment;Behavioral;behavioral construct;Biosensor;Brain Health Registry;Cellular Phone;Censuses;Clinical;Code;Cognitive;cognitive ability;cognitive change;cognitive testing;Communities;Computer software;Computers;cost;Data;Data Collection;data de-identification;data management;Data Scientist;data sharing;Decision Making;Development;Discipline;Early Diagnosis;Early Intervention;Economics;Ecosystem;Education;Emotional;Ensure;Ethnic Origin;evidence base;experience;Family;Funding;Gait speed;Galvanic Skin Response;Gender;Goals;handheld mobile device;Health;heart rate variability;Impaired cognition;improved;Informal Social Control;Information Systems;Institution;instrument;International;Intervention;Libraries;life span;Location;Measurement;Measures;mild cognitive impairment;mobile application;Modeling;Monitor;Motivation;Neurologic;older adult;open source;Outcome;Ownership;Participant;Pathologic;Patient Outcomes Assessments;Personality;Physical Function;Physiological;Population;Population Heterogeneity;Prevention;Prevention strategy;Process;Protocols documentation;psychologic;Race;Recovery;recruit;remote assessment;Research;Research Design;Research Methodology;Research Personnel;research study;Resources;response;retention rate;Risk Factors;Sampling;Scientist;sensor;Services;skills;smartphone based device;social;socioeconomics;software development;standard measure;Stress;stress reactivity;study population;System;Technology;Testing;tool;Triage;United States National Institutes of Health;Universities;usability

PROJECT_TITLE: The Mobile Toolbox for Monitoring Cognitive and Behavioral Function (MTB2)