NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Caregiving Research;Clinical Research;Mental Health;Neurosciences;Pediatric;Social Determinants of Health

ORG_NAME: COLUMBIA UNIV NEW YORK MORNINGSIDE

PHR: PROJECT NARRATIVE Early caregiving adversity is strongly linked to the emergence of psychopathology but the neurodevelopmental mechanisms remain elusive. The short-term goal of my research is to determine how adaptations in midline cortico-subcortical circuitry following early adversity represent the affective semantic knowledge learned during early caregiving experiences. In the long term, my findings will fuel investigations into the developmental neurocomputational mechanisms of affective semantic memory that are linked to differential risk and resilience for psychopathology in adversity-exposed children and adolescents, identifying novel strategies to intervene when these adaptations are no longer beneficial.

PI_NAMEs: VANNUCCI, ANNA  (contact)

PROGRAM_OFFICER_NAME: ULLRICH, LAUREN ELIZABETH

PROJECT_TERMS: Adolescent;Adult;Affect;Affective;Age;Anxiety;Award;Bayesian Prediction;Behavior;Brain;career;Caregivers;caregiving;Child;Child Behavior;Childhood;Clinical;Code;Cognitive;cognitive neuroscience;computational neuroscience;Computer Models;Computing Methodologies;Coupling;Data;design;Development;early adolescence;early experience;early life adversity;Ecological momentary assessment;Emotional;emotional behavior;Emotions;Environment;Event;experience;experimental study;Faculty;Foundations;Functional Magnetic Resonance Imaging;Funding;Future;Goals;high risk;Human;Human Development;human model;indexing;Individual Differences;innovation;Intervention;Investigation;Knowledge;Lead;Learning;Link;Literature;Machine Learning;Medial;Memory;Mental Depression;Mental disorders;Mental Health;Mentorship;Methodology;Methods;Modeling;National Institute of Mental Health;Nature;neglect;neural;Neurobiology;neurodevelopment;neuroimaging;Neurosciences;novel strategies;Outcome;Parents;Pattern;Phase;Positioning Attribute;post-doctoral training;Postdoctoral Fellow;pre-doctoral;Principal Investigator;Process;Psychopathology;Research;resilience;response;Risk;Role;Sampling;Science;Semantic memory;Semantics;Shapes;skills;social;Statistical Models;Surveys;System;Techniques;tenure track;Testing;theories;Time;Training

PROJECT_TITLE: Neurocomputational Mechanisms of Affective Semantic Memory Development


ADMINISTERING_IC: NS

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: NEW YORK

ORG_COUNTRY: UNITED STATES

ORG_DEPT: NEUROSCIENCES

ORG_FIPS: US

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: PROJECT NARRATIVE An understudied region of the hippocampal formation—the subiculum—has a poorly-defined, but necessary, role in memory retrieval. Subicular atrophy is one of the earliest biomarkers for Alzheimer’s disease, and is robustly associated with cognitive impairment. This proposal seeks to advance our understanding of this neglected region, determine what role it may play in the coordination of brain-wide activity, and generate critical insights into neurodegenerative disease.

PI_NAMEs: O'NEIL, DARIK ANDREW (contact)

PROJECT_TERMS: Address;Alzheimer's Disease;Alzheimer’s disease biomarker;Area;Atrophic;auditory stimulus;Aversive Stimulus;Behavior;Behavioral;Behavioral Assay;Biological Assay;Brain;Brain region;Calcium;career;Cells;clinically significant;Code;computational basis;Computer Analysis;conditioned fear;Cues;design;Development;disadvantaged background;Disease;Electrophysiology (science);Engineering;Ensure;experimental study;fear memory;Functional disorder;functional group;Goals;Head;Hippocampal Formation;Hippocampus;Holography;Image;Immediate-Early Genes;Impaired cognition;in vivo optical imaging;insight;Knowledge;Laboratories;large scale data;Learning;Life;light weight;Measures;Memory;Memory impairment;memory recall;memory retrieval;Mentorship;multi-photon;Mus;neglect;neural;Neurobiology;Neurodegenerative Disorders;Neurons;Neurosciences;novel;optogenetics;Output;Pathologic;Phase;Physiological;Play;Positioning Attribute;Postdoctoral Fellow;pre-clinical research;Protocols documentation;Recording of previous events;Recurrence;Research;Research Personnel;Research Project Grants;Resolution;response;Retrieval;Role;skills;Slide;Specificity;Stimulus;System;Testing;Training;two-photon

PROJECT_TITLE: The Neglected Subiculum: Decoding and Manipulating Memory Retrieval with Multiphoton Holography


ADMINISTERING_IC: AG

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PI_NAMEs: RAFTERY, DANIEL  (contact)

PROJECT_TERMS: age related;Aging;aging related;Alabama;Artificial Intelligence;biogerontology;Bioinformatics;Biological Assay;Biology of Aging;Collaborations;Communities;Complex;cost;Country;Data;Data Analyses;Data Set;data sharing networks;Development;Ensure;Experimental Designs;extend lifespan;Genes;Genetic;genetic approach;Geroscience;Geroscientist;Goals;Grant;healthspan;Human;interest;Invertebrates;Light;Link;Longevity;Manuscripts;Measures;Metabolism;metabolome;metabolomics;method development;Methods;Modeling;Molecular Genetics;multidimensional data;multiple omics;network models;new therapeutic target;novel;Oklahoma;Organism;Pathway Analysis;Pathway interactions;Pattern;Phenotype;Play;potential biomarker;Preparation;Proteins;Proteome;Proteomics;Reporting;repository;Research Personnel;Resources;Running;sample collection;Sampling;senescence;Shapes;Shock;small molecule;software development;Software Tools;Statistical Data Interpretation;Statistical Methods;tool;Universities;Washington;Work

PROJECT_TITLE: Core D: Metabolite Phenotypes of Aging


PI_NAMEs: MENDENHALL, ALEXANDER RICHARD (contact)

PROJECT_TERMS: Age;age-related disease;Aging;aging population;aging process;aging related;Animals;Area;behavioral phenotyping;Biochemical;Biological;Biological Assay;Biology of Aging;Biomedical Research;Caenorhabditis elegans;cell age;Cells;Chronology;Collaborations;Color;Communities;Complex;Computer Analysis;Data;Development;Devices;Education and Outreach;experimental study;Fluorescence Microscopy;Funding;genetic selection;Goals;healthspan;high dimensionality;Histones;Hour;Individual;innovation;interest;Invertebrates;Label;learning materials;Left;life span;light microscopy;Longevity;magnetic beads;Measures;Methodology;Methods;Microfluidics;microscopic imaging;model organism;Modeling;Modification;Molecular;Mothers;Movement;movie;Mutation;Nematoda;new technology;novel strategies;Nuclear Pore;optical spectra;Perception;Phenotype;Pilot Projects;Population;Proteins;Reporter;Research;Research Personnel;Resolution;Resources;robotic system;Robotics;Saccharomyces cerevisiae;Saccharomycetales;Sampling;Scheme;Services;Shock;Technology;Time;tool;Training;Work;Yeasts

PROJECT_TITLE: Core E: Invertebrate Longevity and Healthspan


NIH_SPENDING_CATS: Aging;Bioengineering;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

PI_NAMEs: LEE, SU-IN  (contact)

PROJECT_TERMS: Aging;Area;Artificial Intelligence;automated algorithm;Big Data;Bioinformatics;Biological Assay;Biology of Aging;Biomedical Research;Caenorhabditis elegans;Collaborations;Communities;Computer Vision Systems;Consultations;Data Analyses;Data Set;design;digital imaging;Ensure;Environment;Experimental Designs;experimental study;feature detection;Genes;Genotype;Geroscience;Goals;healthspan;high dimensionality;interest;Laboratories;life span;Longevity;metabolomics;Methodology;Multiomic Data;multiple omics;Phenotype;Pilot Projects;Proteomics;Publications;Reproducibility;Research;Research Personnel;Research Project Grants;Resources;service utilization;Services;Shock;trait;Transcript;Yeasts

PROJECT_TITLE: Core F: Artificial Intelligence and Bioinformatics


ADMINISTERING_IC: NR

ED_INST_TYPE: SCHOOLS OF NURSING

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Prevention

ORG_CITY: ORLANDO

ORG_NAME: UNIVERSITY OF CENTRAL FLORIDA

ORG_STATE: FL

PHR: Project Narrative Older adults with cancer are at risk for severe negative outcomes related to chemotherapy-induced nausea and vomiting (CINV) during treatment with chemotherapy due to poor self-management. Early reinforcement of standard education and reframing preconceived beliefs about the ability of CINV to be successfully managed through serious games will increase self-care behaviors and improve patient outcomes. The purpose of this study is to investigate the effectiveness of a serious game intervention in reducing CINV severity and healthcare use and increasing functioning and quality of life in older adults.

PI_NAMEs: LOERZEL, VICTORIA  (contact)

PROGRAM_OFFICER_NAME: MCNAMARA, KAREN MARIE

PROJECT_TERMS: academic standard;Accident and Emergency department;Address;Adherence;Adopted;Adult;adverse event risk;Age Years;Anti-emetics;attentional control;Behavior;Belief;cancer diagnosis;Cancer Patient;cancer therapy;care seeking;chemotherapy;clinical research site;Clinical Trials Design;Cognitive;cognitive change;comparison control;comparison intervention;Control Groups;cost;daily functioning;Data;Decision Making;Dehydration;Education;Effectiveness;effectiveness evaluation;efficacy evaluation;Electronics;Emergency department visit;Enrollment;Environment;Exclusion;experience;Exposure to;Florida;follow-up;Food;Fright;functional improvement;Goals;group intervention;Guidelines;Health;Health behavior;Healthcare;high risk;Home;Hospitalization;human old age (65+);Impairment;improved;Intervention;Kidney;Learning;Liquid substance;Malignant Neoplasms;Nausea;Nausea and Vomiting;Nausea and Vomiting Therapy;Newly Diagnosed;non-compliance;novel;older adult;Oncologist;Outcome;Pain;Participant;Patient observation;Patient-Focused Outcomes;Patients;Perception;Pharmaceutical Preparations;Physicians;Pilot Projects;Play;Population;prevent;Prevention;Prevention strategy;primary outcome;Provider;Psychological reinforcement;Quality of life;Randomized;randomized, clinical trials;recruit;Reporting;Research;Research Personnel;Research Priority;Rest;Risk;Risk Reduction;Sample Size;Sampling;secondary outcome;Self Care;Self Management;Severities;side effect;simulation;symptom self management;Symptoms;Technology;Testing;Toxic effect;Training;Treatment-related toxicity;United States National Institutes of Health;Visit;Visualization;Work;young adult

PROJECT_TITLE: Serious gaming for chemotherapy-induced nausea and vomiting in older adults with cancer: A randomized clinical trial

STUDY_SECTION: CMGC

STUDY_SECTION_NAME: Clinical Management in General Care Settings Study Section[CMGC]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Mental Health;Neurosciences;Pediatric;Prevention;Sleep Research;Substance Misuse;Underage Drinking

ORG_CITY: MENLO PARK

ORG_NAME: SRI INTERNATIONAL

ORG_STATE: CA

PHR: PROJECT NARRATIVE Heavy alcohol drinking during adolescence is known to disturb brain development and functioning and increase risk of drinking problems in adulthood, but the extent of the lingering effects of youthful drinking on adult functioning remains unclear. The goal of NCANDA-A (Adulthood) is to determine how adolescent alcohol-related disruption of normal brain growth patterns of structure, related brain function, and psychiatric health affects brain functioning in emerging adulthood. Determining which affected processes remain impaired and which escape alcohol's untoward effects will specify how a youthful-drinking history influences quality of life in adulthood, information obtained only from longitudinal study as proposed by NCANDA-A.

PI_NAMEs: BAKER, FIONA C (contact);DE ZAMBOTTI, MASSIMILIANO

PROGRAM_OFFICER_NAME: LORANG-LEINS, DOMINIQUE

PROJECT_TERMS: 21 year old;Abstinence;Acceleration;Acute;Adolescence;Adolescent;adolescent binge drinking;Adult;Adverse effects;Affect;Affective;Age;Alcohol abuse;Alcohol consumption;alcohol cue;alcohol effect;alcohol expectancy;alcohol use disorder;alcohol use initiation;Alcohols;Behavioral;binge drinking;Biological;Brain;Clinical;Cognition;Cognitive;cognitive control;cognitive performance;cohort;Communities;Computers;COVID-19 impact;COVID-19 pandemic effects;cue reactivity;Data;design;Development;Distress;Dose;drinking;drinking onset;early onset;Economics;Elements;emerging adult;emerging adulthood;Emotional;Event;experience;externalizing behavior;Family;Female;follow-up;Frequencies;Functional Magnetic Resonance Imaging;Goals;gray matter;Growth;Health;heart function;Heart Rate;Heavy Drinking;Home;Impairment;improved;Individual;information processing;International;Learning;Life;Life Stress;Link;Longitudinal Studies;Machine Learning;Magnetic Resonance Imaging;male;Measures;Mediating;medical specialties;Memory;Mission;mobile application;Modeling;modifiable risk;Monitor;multimodal neuroimaging;neural;neurodevelopment;neuroimaging;neuropsychiatry;novel;Outcome;Outcome Measure;pandemic disease;Patient Recruitments;Pattern;Personal Satisfaction;Persons;Physical activity;Polysomnography;Positioning Attribute;post-pandemic;pre-pandemic;Process;Protocols documentation;Psychopathology;Psychosocial Factor;Quality of life;Recording of previous events;Recovery;recruit;Research Project Grants;response;Rest;retention rate;Risk;Risk Factors;Sampling;Schools;Sex Differences;Sex Differentiation;Site;Sleep;Sleep disturbances;social;Specific qualifier value;Stress;Structure;Symptoms;System;Technology;Testing;underage drinking;Work

PROJECT_TITLE: National Consortium on Alcohol and NeuroDevelopment in Adolescence - SRI International Research Project Site (NCANDA-SRI)


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Neurosciences;Rare Diseases

ORG_CITY: SAN ANTONIO

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

ORG_STATE: TX

PHR: This project will address the biological roles and the molecular mechanisms of the novel signaling pathway mediated by a secreted protein, IGSF10. The basic science knowledge gained from this project will help the understanding of the roles played by IGSF10 in a variety of biological and pathological processes at the molecular levels and facilitate future therapeutic approaches to pathological conditions associated with IGSF10 dysregulation.

PI_NAMEs: SHIIO, YUZURU  (contact)

PROGRAM_OFFICER_NAME: XU, WANPING

PROJECT_TERMS: Basic Science;Binding;Biological;Biological Process;Biology;C-terminal;Cell Line;Cell model;Cell Proliferation;Cell Surface Proteins;Cell Surface Receptors;Cells;Cleidocranial Dysplasia;cofactor;Collaborations;Complex;Cysteine-Rich Domain;Delayed Puberty;Ewings sarcoma;Foundations;Frameshift Mutation;Future;Gene Expression;Glioma;Gonadotropin Hormone Releasing Hormone;Growth;hormone deficiency;Human;immunoglobulin receptor;Immunoglobulins;Inherited;inhibitor;kinase inhibitor;knock-down;Knowledge;Leucine-Rich Repeat;Ligands;Link;Malignant Breast Neoplasm;Malignant neoplasm of lung;Mediating;member;Microglia;migration;Molecular;Mus;mutant;Mutation;N-terminal;National Institute of Neurological Disorders and Stroke;Neurons;novel;olfactomedin;Pathologic;Pathologic Processes;Pathway interactions;Phenocopy;Physiological;Pituitary Hormones;Play;prevent;protein function;Protein Secretion;Protein Tyrosine Kinase;Proteomics;proto-oncogene protein c-ret;receptor;Research;RET inhibition;Role;Signal Pathway;Signal Transduction;skeletal disorder;Structure;System;Testing;Therapeutic;Tissues;transcriptome sequencing;tumor;United States National Institutes of Health;Variant

PROJECT_TITLE: The role of the receptor complex and the cofactors in IGSF10 signaling

STUDY_SECTION: CSRS

STUDY_SECTION_NAME: Cellular Signaling and Regulatory Systems Study Section[CSRS]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Clinical Research;Disability Research;Hearing Loss;Precision Medicine;Prevention;Rehabilitation

ORG_CITY: CHARLESTON

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: PROJECT NARRATIVE Cochlear implants (CIs) are the standard treatment for adults with moderate to profound sensorineural hearing loss who no longer benefit from hearing aids. This project enhances the interpretation and application of a new CI-specific quality of life measure so functional abilities can be tracked over time with the goal of improving hearing loss treatments for adults with moderate to profound hearing loss. This is directly relevant to the NIH’s mission as it seeks and applies knowledge to enhance human life.

PI_NAMEs: MCRACKAN, THEODORE RICHARDSON (contact)

PROGRAM_OFFICER_NAME: KING, KELLY ANNE

PROJECT_TERMS: Activities of Daily Living;Adult;Benchmarking;Caring;Clinical;clinical care;clinical decision-making;clinical outcome measures;clinical practice;Cochlear implant procedure;Cochlear Implants;cohort;Communication;Counseling;Data;deaf;design;Development;digital platform;Early identification;Evaluation;evidence base;experience;functional improvement;functional outcomes;Goals;Guidelines;Hearing;Hearing Aids;hearing loss treatment;Human;implantation;implementation science;improved;Individual Differences;individual patient;Institution;instrument;interest;Intervention;Interview;Knowledge;Language;Left;Life;Longitudinal cohort study;Longitudinal Studies;Measures;Methodology;Methods;Mission;Modeling;Modernization;Monitor;novel;novel strategies;Operative Surgical Procedures;Outcome;Outcome Measure;Pathologist;Patient Care;patient oriented;Patient Outcomes Assessments;Patients;Personal Satisfaction;personalized care;Phase;Postoperative Period;precision medicine;preimplantation;Process;programs;Protocols documentation;Psyche structure;Psychometrics;Quality of life;real world application;Rehabilitation therapy;Reporting;Research;Research Design;Resources;response;Risk;Sampling;Sensorineural Hearing Loss;shared decision making;Site;skills;social engagement;sound;Speech;speech recognition;Staging System;standard care;Standardization;Surgeon;Testing;Time;tool;Translating;United States National Institutes of Health;Validation

PROJECT_TITLE: Interpreting Functional Cochlear Implant Outcomes for Individual Patients

STUDY_SECTION: HSQE

STUDY_SECTION_NAME: Health Services: Quality and Effectiveness Study Section[HSQE]


NIH_SPENDING_CATS: Biotechnology;Cancer;Immunotherapy

ORG_CITY: ATLANTA

ORG_DEPT: SURGERY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Narrative: Adoptively transferred T cells has emerged as a powerful immunotherapy. Our unpublished work now suggests that antitumor immunity can augmented by targeting Rexo2, an oligoribonuclease induced in the mitochondria of PI3K?-inhibited T cells, a finding that has important implications for treating patients in the future.

PI_NAMEs: PAULOS, CHRYSTAL MARY (contact)

PROGRAM_OFFICER_NAME: LIU, YIN

PROJECT_TERMS: Ablation;Address;Adoptive Cell Transfers;Adoptive Transfer;Animals;Antigen Targeting;antigen-specific T cells;Autoimmune;Bioenergetics;Biogenesis;cancer immunotherapy;Cancer Patient;cancer therapy;Cells;Cellular Metabolic Process;chimeric antigen receptor T cells;Clinical;clinically relevant;Collaborations;Complement;Cytoprotection;Data;defined contribution;empowerment;Endowment;Engineering;Engraftment;Enzymes;exhaustion;fighting;Future;Genetic;Height;Human;Immunity;Immunotherapy;Impairment;improved;In Vitro;in vivo;Infection;inhibitor;innovation;insight;Investigation;Lung;Lymphoid;Lymphoid Tissue;Malignant Neoplasms;Mediating;Melanoma patient;Memory;mesothelin;Metabolic;Metabolic Pathway;Metabolism;Metastatic Neoplasm to the Lung;Mitochondria;Monitor;mouse model;Mus;Neoplasm Metastasis;novel;novel strategies;oligoribonuclease;overexpression;pancreatic neoplasm;Pathway interactions;Patients;pharmacologic;Phenotype;PIK3CG gene;Primary Neoplasm;Property;Protein Isoforms;Publications;Recurrent tumor;Reporting;Research;response;RNA;Role;side effect;Signal Pathway;Signal Transduction;Skin;Solid Neoplasm;stem;stemness;Supporting Cell;Surgical Oncology;System;T cell therapy;T memory cell;T-Lymphocyte;Testing;Therapeutic;Tissues;transcriptome sequencing;translational impact;Translational Research;tumor;Tumor Antigens;tumor eradication;Tumor Immunity;tumor metabolism;Tumor Tissue;unpublished works;Viral;Vitiligo;Work

PROJECT_TITLE: Mechanisms of Durable Antitumor Immunity Mediated by PI3K-targeted T cells

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-TIO-D(01)Q]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: Columbus

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Sepsis is a devastating illness with high mortality. Most studies have investigated inflammation in sepsis, although many people are prone to immune suppression with impaired ability to fight infections. We have discovered a new model that may explain immune suppression in sepsis that led us to propose characterizing a protein that restores immune function. This discovery fulfills an unmet need in this critical illness.

PI_NAMEs: MALLAMPALLI, RAMA K (contact)

PROGRAM_OFFICER_NAME: ZHOU, GUOFEI

PROJECT_TERMS: Acute;Anti-Inflammatory Agents;Bacterial Infections;Binding;Biological;Caring;Cartoons;Cause of Death;Cell Death;Clinical;Clinical Trials;Critical Illness;cytokine;cytokine release syndrome;Cytoprotection;Data;Disease;Effector Cell;Endotoxins;Epithelial Cell Proliferation;Epithelial Cells;epithelial repair;Epithelium;Equilibrium;Experimental Models;extracellular;F-Box Proteins;Failure;fighting;Foundations;Functional disorder;Gene Transfer;Genetic Engineering;Homeostasis;Host Defense;Human;Immune;immune function;Immune response;Immunologic Stimulation;Immunological Models;immunoreactivity;Immunosuppression;Immunosuppressive Agents;Impairment;In Vitro;in vivo;Infection;Inflammation;Inflammatory;innate immune function;Innate Immune Response;Innate Immune System;Invaded;Knockout Mice;Link;loss of function;Lung;Mediating;microbial;Mitochondria;Modeling;Molecular;molecular modeling;mortality;Multiple Organ Failure;Mus;Natural Immunity;novel;opportunistic pathogen;organ injury;Pathogenesis;pathogenic microbe;Pathway interactions;Patients;Persons;Pharmacotherapy;Phase;Play;pneumonia model;Pre-Clinical Model;preservation;Prognosis;Proliferating;protein degradation;Protein Secretion;Proteins;receptor;repaired;response;Role;S-Phase Fraction;Sepsis;Site;superinfection;synthetic protein;System;Testing;tissue injury;Ubiquitin;Ubiquitin-mediated Proteolysis Pathway;ubiquitin-protein ligase;Ubiquitination;Work

PROJECT_TITLE: Sepsis-Associated Immune Suppression and F-box Proteins

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Mental Health;Neurosciences;Sleep Research

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PI_NAMEs: BAZHENOV, MAKSIM V (contact)

PROGRAM_OFFICER_NAME: VAZIRI, SIAVASH

PROJECT_TITLE: CRCNS: Neural computations underlying sequence memory consolidation in sleep


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Complementary and Integrative Health;Natural Products;Neurosciences;Opioids

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

PHR: Project Narrative  The bark of Galbulimima sp. features in the traditional medicine and ritual of Papua New Guinea, but the psychoactive principles have not been identified. This proposal discloses new biomolecular targets of the Galbulimima alkaloids, preliminary pharmacological data that demonstrates rapid brain penetration and a chemical platform to enable broad experimental interrogation. These studies will allow the exploration of a broad but remote area of complex natural product space and translation to new therapeutics based on natural remedies.

PI_NAMEs: BOHN, LAURA M.;SHENVI, RYAN ASHOK (contact)

PROGRAM_OFFICER_NAME: STILL, PATRICK COLBY

PROJECT_TERMS: Absence of pain sensation;addiction;Affect;Affinity;Agonist;Alkaloids;Analgesic and Antipyretic;analog;antagonist;Area;Behavior;Binding;Biological;Biological Assay;Bradycardia;Brain;Cell Respiration;Cells;Central Nervous System;chemical synthesis;Chemicals;Chemistry;combinatorial;Communities;Complex;Coupled;Coupling;Data;decalin;Development;Drug Kinetics;Family;Fever;follow-up;G-Protein-Coupled Receptors;Goals;Grant;Grooming;Hallucinations;Hallucinogens;Human;In Vitro;in vivo;Individual;Ingestion;interest;Intestines;Investigation;kappa opioid receptors;Lead;Letters;Libraries;Ligands;member;Metabolism;Methods;mu opioid receptors;Mus;Natural Products;Natural Remedy;Needles;novel therapeutics;Opioid;Opioid Receptor Binding;Oryctolagus cuniculus;Outcome;Papua New Guinea;Penetration;Pharmaceutical Preparations;Pharmacodynamics;pharmacologic;Pharmacology;piperidine;plant metabolites;programs;Reaction;receptor;Reporting;Research;Research Personnel;Residual state;Resolution;Ritual compulsion;Role;Route;Sampling;scaffold;Scientist;Second Messenger Systems;social stigma;Spasm;Spasmolytics;Stimulant;structural biology;Structure;Structure-Activity Relationship;therapeutic development;Traditional Medicine;Translations;treatment-resistant depression;Trees;Variant;Work

PROJECT_TITLE: Deconvolution of Galbulimima bark pharmacology through chemical synthesis and target assignment

STUDY_SECTION: SBCB

STUDY_SECTION_NAME: Synthetic and Biological Chemistry B Study Section[SBCB]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Mental Health;Neurosciences

ORG_CITY: BELMONT

ORG_NAME: MCLEAN HOSPITAL

ORG_STATE: MA

PHR: NARRATIVE Despite decades of major advances in the ability to study the brain processes that control behavior, we have not yet reached the goal of translating this new knowledge into breakthroughs in treating psychiatric illness. Progress has been limited by the fact that few researchers have a combined understanding of psychiatric illness as it appears in humans and how it is studied in laboratory models, which limits effective communication across disciplines and translation of discoveries into treatments. This McLean Hospital training program is designed to ensure that postdoctoral trainees develop a sophisticated understanding of both psychiatry and neuroscience by utilizing specialized mentorship teams with expertise that covers both disciplines.

PI_NAMEs: CARLEZON, WILLIAM A. (contact);RESSLER, KERRY J.

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: Neurosciences;Psychiatry;Training

PROJECT_TITLE: Training to Enhance Alignment of Psychiatry and Neuroscience


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Congenital Structural Anomalies;Immunotherapy;Kidney Disease;Pediatric;Polycystic Kidney Disease

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: Project Narrative In this study, we will investigate the roles of programmed cell death protein 1 (PD-1) and its ligand, PD-1, in ADPKD. We will address two main concerns in PKD field, including, 1) whether and how cystic epithelial cells escape immune attacks in cyst microenvironment in which T cells and macrophages are increased; and 2) whether and how PKD mutant cystic renal epithelial cells affects the adjacent cell function during cyst initiation and progression. Accomplishing this study will lead to a better understanding of the mechanism of immune surveillance in renal cyst formation and the roles of cystic cell exosomes in regulating immunosuppression and other cell-to-cell communication, which will provide novel therapeutic strategy for ADPKD treatment.

PI_NAMEs: LI, XIAOGANG  (contact)

PROGRAM_OFFICER_NAME: MARIC-BILKAN, CHRISTINE

PROJECT_TERMS: Affect;Animal Model;Antibodies;Area;Autosomal Dominant Polycystic Kidney;Binding;cancer cell;Cell Communication;Cell Physiology;Cells;Clinical;Collagen;Communication;Cyst;Cystic kidney;cytokine;Data;Dendritic Cells;Development;Disease;Disease Progression;Epithelial Cell Proliferation;Epithelial Cells;exosome;Fibroblasts;Gel;Genetic;Growth;Human;human model;humanized antibody;Immune;Immune Evasion;Immune response;Immune system;Immunologic Surveillance;Immunosuppression;Immunosuppressive Agents;Immunotherapy;improved;in vivo;Inflammation;inhibitor;interstitial;Investigation;Kidney;Knock-out;Knockout Mice;Ligands;lymphocyte proliferation;Macrophage;Mediating;Migration Inhibitory Factor;mouse model;Mus;mutant;mutant mouse model;Mutant Strains Mice;neoplastic cell;novel therapeutic intervention;Patients;Play;Population;pre-clinical;programmed cell death ligand 1;programmed cell death protein 1;Publications;recruit;renal epithelium;Reporting;Role;Signal Transduction;Stimulus;Structure;Surface;T-Cell Activation;T-Cell Receptor;T-Lymphocyte;Testing;Time;Tissues;TNF gene;tumor;Tumor Escape;tumor microenvironment;tumor-immune system interactions;Tumor-infiltrating immune cells;Up-Regulation;urinary;Urine

PROJECT_TITLE: ADPKD: Understanding immunosuppression mechanisms and discovering treatment

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-J(05)]


ADMINISTERING_IC: AR

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Genetics

ORG_CITY: UNIVERSITY PARK

ORG_DEPT: MISCELLANEOUS

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

ORG_STATE: PA

PHR: PROJECT NARRATIVE This project will discover novel mechanisms controlling muscle ribosome production and hypertrophy. These data will define the molecular targets through which ribosomal production can be stimulated to promote muscle growth. The outcomes of this study provide the translational framework to prevent muscle loss and weakness associated with aging, cancer and other chronic diseases.

PI_NAMEs: NADER, GUSTAVO A (contact)

PROGRAM_OFFICER_NAME: LINDHURST, MARJORIE JEAN

PROJECT_TERMS: Ablation;Aging;Animal Model;Biology;Cancer Cachexia;Chromatin;chromatin modification;chromatin remodeling;Chromatin Remodeling Factor;Chronic;Chronic Disease;Complex;Convalescence;Data;Deacetylation;design;DNA Polymerase I;End stage renal failure;Environment;Enzymes;Epigenetic Process;epigenetic regulation;Excision;gain of function;Gene Dosage;Gene Expression;Genes;Genetic;Genetic Transcription;Goals;Growth;HDAC1 gene;Health;Human;Hypertrophy;In Vitro;in vivo;innovation;Knowledge;life span;loss of function;Maintenance;Malignant Neoplasms;mechanical load;Mediating;Methylation;Modeling;Molecular;Molecular Chaperones;Molecular Target;Morphology;mortality;mouse model;Muscle;Muscle Fibers;muscle form;Muscle function;muscle hypertrophy;Muscle Weakness;Muscular Atrophy;novel;novel strategies;Outcome Study;permissiveness;Play;prevent;Production;promoter;Protein Biosynthesis;Relaxation;Reporting;Repression;Resistance;response;Retinoblastoma Protein;Ribosomal DNA;Ribosomes;RNA;RNA Polymerase I;Rodent;Role;rRNA Genes;sarcopenia;Series;Skeletal Muscle;stoichiometry;Stress;Testing;therapy development;transcription factor;transcription factor UBF;transcription factor USF;translational framework

PROJECT_TITLE: Ribosomal control of muscle mass: Transcriptional and epigenetic mechanisms

STUDY_SECTION: SMEP

STUDY_SECTION_NAME: Skeletal Muscle and Exercise Physiology Study Section[SMEP]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PUBLIC HEALTH RELEVANCE STATEMENT Inhibitory neurons are essential elements of any circuit and defects in inhibitory function can lead to neurological disorders and mental illnesses. The CA3 region of the hippocampus is a central brain region for computing learning and memory, yet there are very few studies investigating how inhibitory neurons regulate CA3 function. Our proposal will determine how the activity of different types of GABA neurons regulate CA3 pyramidal cell activity, learning, and memory in mice.

PI_NAMEs: HEYS, JAMES GERARD;WILLIAMS, MEGAN ELISE (contact)

PROGRAM_OFFICER_NAME: FERNANDEZ, FERNANDO R

PROJECT_TERMS: Adhesions;Affect;Area;autism spectrum disorder;Axon;Behavior;Brain;Brain Diseases;Brain region;cellular imaging;conditioned fear;Defect;Dendrites;dentate gyrus;designer receptors exclusively activated by designer drugs;Discrimination;Distal;Electron Microscopy;Elements;Environment;Equilibrium;Excitatory Synapse;experimental study;Face;fear memory;Filopodia;Fright;gamma-Aminobutyric Acid;Genes;Genetic;Glutamates;Head;hippocampal pyramidal neuron;Hippocampus;Image;Individual;inhibitory neuron;Intellectual functioning disability;Knowledge;Learning;Mediating;Memory;memory encoding;memory retrieval;Mental disorders;mossy fiber;Mus;Nervous System Disorder;neuronal cell body;Neuronal Dysfunction;Neurons;Outcome;Parvalbumins;Pattern;Physiological;Play;postsynaptic neurons;predictive modeling;presynaptic;presynaptic neurons;Presynaptic Terminals;Proteins;public health relevance;Pyramidal Cells;Recurrence;Regulation;Risk Factors;Role;Runaway;selective expression;Site;Specificity;Structure;Synapses;Testing;virtual reality;Work

PROJECT_TITLE: Inhibitory regulation of hippocampal CA3 neuron activity, learning, and memory

STUDY_SECTION: LMDN

STUDY_SECTION_NAME: Learning, Memory and Decision Neuroscience Study Section[LMDN]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Infectious Diseases;Natural Products

ORG_CITY: NOTRE DAME

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF NOTRE DAME

ORG_STATE: IN

PHR: Project Narrative Bacteria become progressively resistant to all existing antibiotics, rendering them obsolete. Gram-negative bacteria are among the most nefarious human pathogens that have evolved a host of resistance mechanisms. These are among the most difficult pathogens to treat clinically. I describe our work on the bulgecin class of compounds, which sensitize Gram-negative bacteria to the action of b-lactam antibiotics, a process referred to as potentiation. I disclose a strategy in discovery of a suitable bulgecin analog and a b-latam antibiotic that would fight infections by Gram-negative bacteria.

PI_NAMEs: MOBASHERY, SHAHRIAR  (contact)

PROGRAM_OFFICER_NAME: XU, ZUOYU

PROJECT_TERMS: Address;analog;Anti-Bacterial Agents;Antibiotics;Applications Grants;Aspartate;Aspartic Acid;Attention;Bacteria;bactericide;beta-Lactams;Binding;Biological;Ceftazidime;chemical synthesis;Chemosensitization;Clinical;Complex;Computer Analysis;Cytolysis;Event;Exhibits;experimental study;Failure;fighting;Fluorescence Microscopy;Gene Cluster;Genes;Gram-Negative Bacteria;Gram-Negative Bacterial Infections;Host resistance;human pathogen;In Vitro;in vivo;Infection;lead optimization;Lytic;Meropenem;Methodology;Methods;Monobactams;Natural Products;novel;novel strategies;Organism;pathogen;Pathway interactions;Penetration;periplasm;Phase;Preparation;Process;Production;Property;Pseudomonas aeruginosa;Pseudomonas aeruginosa infection;Reaction;Reporting;Research;Resistance;resistance mechanism;Rodent Model;Roentgen Rays;Scanning Electron Microscopy;Series;Serine;Site;Structure;Work

PROJECT_TITLE: Bulgecin Template for Potentiation of beta-Lactam Antibiotics

STUDY_SECTION: DDR

STUDY_SECTION_NAME: Drug Discovery and Mechanisms of Antimicrobial Resistance Study Section[DDR]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: PHILADELPHIA

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

PHR: Project Narrative The proposed study will significantly contribute to the field of HIV prevention by providing insight into how the power of social media and trans women social influencers can be used to deliver PrEP information to affect knowledge, perceptions and potential uptake of PrEP. Using trans women focused PrEP materials developed in a previous study, we will identify and train trans women social influencers who will provide those messages through an Instagram-based intervention called SIS (Sisters Influencing Sisters) and assess acceptability, feasibility, and promise of efficacy in changing PrEP perceptions and intentions in trans women followers.

PI_NAMEs: BASS, SARAH B (contact);ZAMUDIO-HAAS, SOPHIA ALEXANDRA

PROGRAM_OFFICER_NAME: SCOTT-SHELDON, LORI ANN JENNIFER

PROJECT_TERMS: 3-Dimensional;acceptability and feasibility;Address;Adherence;Affect;AIDS prevention;Area;artist;Attitude;Awareness;Bass;Behavioral;Caring;Clinical;clinical research site;cohort;Collection;Communication;Communities;community advisory board;Consult;Counseling;Data;Decision Making;design;Dimensions;Discrimination;experience;Funding;Future;gender affirmation;Hair;Health;health care settings;health communication;high risk;HIV;HIV Infections;hormone therapy;Image;implementation evaluation;implementation framework;implementation intervention;implementation science;improved;innovation;insight;Instagram;Intervention;Knowledge;Location;Los Angeles;Maps;Marketing;mathematical model;Measures;Medical;member;Methods;Modeling;Monitor;National Institute of Mental Health;New York;novel;Outcome;Participant;peer;Perception;Persons;Philadelphia;pilot test;pre-exposure prophylaxis;Prophylactic treatment;recruit;Reporting;Research;Resources;Sampling;San Francisco;Sister;social;Social Development;social engagement;social interventions;social media;social stigma;Standardization;Surveys;Techniques;Testing;tool;Training;transgender;transgender women;Trust;United States;uptake;vector;Work

PROJECT_TITLE: Data-driven, peer-led messaging using social media influencers to increase PrEP awareness and uptake among transgender women

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


ORG_CITY: PORTLAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PI_NAMEs: NAGEL, BONNIE J (contact)

PROGRAM_OFFICER_NAME: KUMAR, SHAILESH

PROJECT_TERMS: Abstinence;Acceleration;Acute;Adolescence;Adolescent;adolescent binge drinking;Adult;Adverse effects;Affect;Affective;Age;Alcohol abuse;Alcohol consumption;alcohol cue;alcohol effect;alcohol expectancy;alcohol use disorder;alcohol use initiation;Alcohols;Behavioral;binge drinking;Biological;Brain;Clinical;Cognition;Cognitive;cognitive control;cognitive performance;cohort;Communities;Computers;COVID-19 impact;COVID-19 pandemic effects;cue reactivity;Data;design;Development;Distress;Dose;drinking;drinking onset;early onset;Economics;Elements;emerging adult;emerging adulthood;Emotional;Event;experience;externalizing behavior;Family;Female;follow-up;Frequencies;Functional Magnetic Resonance Imaging;Goals;gray matter;Growth;Health;heart function;Heart Rate;Heavy Drinking;Home;Impairment;improved;Individual;information processing;Learning;Life;Life Stress;Link;Longitudinal Studies;Machine Learning;Magnetic Resonance Imaging;male;Measures;Mediating;medical specialties;Memory;Mission;mobile application;Modeling;modifiable risk;Monitor;multimodal neuroimaging;neural;neurodevelopment;neuroimaging;neuropsychiatry;novel;Outcome;Outcome Measure;pandemic disease;Pattern;Personal Satisfaction;Persons;Physical activity;Polysomnography;Positioning Attribute;post-pandemic;pre-pandemic;Process;Protocols documentation;Psychopathology;Psychosocial Factor;Quality of life;Recording of previous events;Recovery;recruit;Research Project Grants;response;Rest;retention rate;Risk;Risk Factors;Sampling;Schools;Sex Differences;Sex Differentiation;Site;Sleep;Sleep disturbances;social;Specific qualifier value;Stress;Structure;Symptoms;System;Technology;Testing;underage drinking;Work

PROJECT_TITLE: National Consortium on Alcohol and Neurodevelopment in Adolescence: OHSU


ORG_CITY: BOSTON

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: Project Narrative Altered metabolism is a feature of colorectal cancer (CRC), although how metabolism contributes to cancer cell survival and resistance to chemotherapy is less understood. In this project we will use novel biochemistry, cellular, and in vivo models to study how a mitochondrial sirtuin pathway regulates CRC metabolism and resistance to chemotherapy. A better understanding of these pathways will provide insight into the role of SIRT4 and de novo nucleotide synthesis in CRC, and may lead to urgently needed precision therapies.

PI_NAMEs: HAIGIS, MARCIA  (contact)

PROGRAM_OFFICER_NAME: WILLIS, KRISTINE AMALEE

PROJECT_TERMS: Adenosine Diphosphate Ribose;Animals;Bar Codes;Biochemical;Biochemistry;biological adaptation to stress;Biological Assay;Biology;cancer cell;Cancer Etiology;cancer survival;Carcinoma;Cell Cycle;cell growth;Cell Proliferation;Cell Survival;Cells;Cessation of life;Chemicals;Chemoresistance;chemotherapy;clinically relevant;Colonic Neoplasms;Colorectal Cancer;colorectal cancer progression;Data;Development;Diagnostic Procedure;Disease Outcome;Enzymes;experimental study;Generations;Genetic;Genetically Engineered Mouse;Genome Stability;Genotoxic Stress;Glutamine;Goals;Growth;Human;Hyperplasia;Image;Immunohistochemistry;improved;in vivo;in vivo Model;innovation;insight;Intestinal Cancer;intestinal epithelium;Intestines;Knowledge;Malignant Neoplasms;Maps;Mass Spectrum Analysis;Mediating;Metabolic;Metabolism;Methods;Mitochondria;mitochondrial metabolism;Modeling;Molecular;mouse model;novel;novel diagnostics;novel therapeutic intervention;Nucleotide Biosynthesis;nucleotide metabolism;Nucleotide Metabolism Alteration;Nucleotides;Oncogenic;Organoids;Pathway interactions;patient derived xenograft model;Patients;Phenotype;physiologic model;Physiological;PIK3CA gene;Precision therapeutics;Proliferating;Protein Family;Proteins;Recycling;refractory cancer;Regulation;Repression;Resistance;resistance mechanism;Resolution;response;Role;Signal Pathway;Signal Transduction;Sirtuins;standard of care;success;Survival Rate;System;targeted treatment;Technology;Testing;tumor;Tumor Burden;tumor metabolism;tumor progression;tumorigenesis;Work;Xenograft Model

PROJECT_TITLE: Sirtuins and Cancer

STUDY_SECTION: TCB

STUDY_SECTION_NAME: Tumor Cell Biology Study Section[TCB]


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Arthritis;Cancer;Immunotherapy

ORG_CITY: HOUSTON

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: PROJECT NARRATIVE Despite unprecedented clinical success in the treatment of advanced cancers, immune checkpoint inhibitor (ICI) therapy can lead to life-/organ-threatening complications, termed immune-related adverse events (irAEs), including arthritis-irAE, colitis-irAE, pneumonitis-irAE, etc. To date, mechanisms and signs that underpin the development of irAEs have not been elucidated; thus, highlighting an urgent need to recognize these toxicities early on and provide an appropriate and timely treatment without compromising anti-tumor immunity in cancer patients. The proposed research will help to identify and evaluate unique and shared mechanistic biomarkers of arthritis-irAE, colitis-irAE, and pneumonitis-irAE, as well as establish the most optimal therapeutic strategies.

PI_NAMEs: NURIEVA, ROZA INSAFETDINOVNA (contact)

PROJECT_TERMS: Address;Advanced Malignant Neoplasm;Arthritis;autoimmune toxicity;Autoimmunity;Biological Markers;Bronchoalveolar Lavage;cancer immunotherapy;Cancer Patient;cancer therapy;Cells;checkpoint therapy;Clinical;Clinical Research;Colitis;Colon;CTLA4 gene;cytokine;Development;Disease;efficacy evaluation;experience;fecal transplantation;Goals;Hospitalization;Human;Immune;Immune checkpoint inhibitor;immune-related adverse events;Immunity;Immunology;Immunotherapy;improved;in vivo;Individuality;inhibitor;Interleukin-6;Knowledge;Life;Lung;Maintenance;Melanoma;Melanoma Tumor;microbiome;Modeling;Molecular;mouse model;Mus;novel;Organ;Pathogenesis;Pathogenicity;Patients;Phenotype;Play;pre-clinical;predictive marker;preservation;programmed cell death protein 1;Pulmonary Inflammation;Reagent;Research;Research Personnel;response;Role;Safety;Sampling;Severities;Severity of illness;Steroids;success;Synovial Fluid;Synovial Membrane;T-Lymphocyte;targeted treatment;Therapeutic;therapeutic biomarker;therapeutic evaluation;therapeutic target;Tissues;TNF gene;Toxic effect;transcriptomics;translational study;Treatment Efficacy;treatment strategy;tumor;Tumor Immunity;tumor immunology;Work

PROJECT_TITLE: Mechanism-rooted therapeutic strategies for immune-related toxicities induced by checkpoint inhibitors


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health

ORG_CITY: Boulder

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF COLORADO

ORG_STATE: CO

PHR: PROJECT NARRATIVE This proposal is to train scientists who will be able to contribute significantly to our understanding of genetic contributions to mental health. This understanding will lead to new approaches to the prevention and alleviation of psychiatric disorders.

PI_NAMEs: FRIEDMAN, NAOMI P.;KELLER, MATTHEW CHARLES (contact)

PROGRAM_OFFICER_NAME: VAN'T VEER, ASHLEE VICTORIA

PROJECT_TERMS: Behavioral Genetics;Mental Health;Research Training

PROJECT_TITLE: Research Training: Mental Health Behavior Genetics


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases

PHR: NARRATIVE Doctors use combinations of antibiotics to try to kill bacteria that are resistant to all available individual antibiotics, but these combinations are only sporadically effective and it is unclear when and why they work. We have discovered a paradigm-shifting, scientific basis underlying the efficacy of combinations that now facilitates the tailored selection of antibiotic cocktails to kill individual bacterial isolates, including those resistant to all available drugs and thought to be untreatable. In this proposal we will broadly validate our combination approach across a wide range of antibiotics and multiple bacterial species, potentially revolutionizing combination therapy and having a major translational impact on patient survival in the era of increasing antibiotic resistance.

PI_NAMEs: WEISS, DAVID S (contact)

PROJECT_TERMS: Acinetobacter baumannii;Antibiotic Resistance;antibiotic resistant infections;Antibiotics;Bacteria;Bacterial Infections;bacterial resistance;bactericide;Carbapenem-resistant Acinetobacter;carbapenem-resistant Enterobacteriaceae;Cells;Cessation of life;chemotherapy;Classification;Clinic;Clinical;clinical diagnostics;Combined Antibiotics;Combined Modality Therapy;design;drug development;efficacy testing;Exhibits;experimental study;extreme prematurity;FDA approved;Future;Immunocompromised Host;In Vitro;in vitro testing;in vivo;in vivo evaluation;Individual;Infection;Intermediate resistance;intraperitoneal;kidney infection;Kidney Transplantation;Klebsiella;Life;Malignant Neoplasms;Medical;Methods;Microbiology;Minor;Modeling;Modern Medicine;mortality;mouse model;Nature;novel therapeutic intervention;novel therapeutics;Operative Surgical Procedures;Patients;Pharmaceutical Preparations;Pharmacodynamics;pharmacokinetic model;pharmacokinetics and pharmacodynamics;Phenotype;Pneumonia;Population;Predisposition;Regimen;Research;Resistance;resistant Klebsiella pneumoniae;resistant strain;Risk;routine screening;Sepsis;Serratia;sound;Stenotrophomonas;synergism;Systemic disease;targeted treatment;Testing;Time;translational impact;Transplant Recipients;Transplantation;Treatment Failure;Validation;Work

PROJECT_TITLE: Exploitation of multiple heteroresistance for effective antibiotic combination therapy


NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Kidney Disease;Precision Medicine

ORG_CITY: ANN ARBOR

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Narrative / Public Relevance Statement Almost 300,000 patients undergo cardiac surgery in the US each year, and up to 30% develop cardiac surgery- associated acute kidney injury (CSA-AKI), increasing mortality by up to 10-fold and adding $10-40K to hospital expenditures per case. Beyond patient and surgical baseline characteristics, intraoperative and early postoperative ICU processes of care vary widely across hospitals and remain a critically understudied data source for developing a precision understanding of factors contributing to CSA-AKI. We will (i) identify modifiable intraoperative and early postoperative practices associated with reduced risk of CSA-AKI; (ii) estimate the most effective strategy for reducing CSA-AKI, comparing individualized care, standardized care, and usual care, and (iii) disseminate and assess the effect of precision feedback on CSA-AKI and relevant processes of care.

PI_NAMEs: MATHIS, MICHAEL ROBERT (contact);SINGH, KARANDEEP

PROGRAM_OFFICER_NAME: SCHULMAN, IVONNE HERNANDEZ

PROJECT_TERMS: Acute Renal Failure with Renal Papillary Necrosis;Address;Adoption;Adult;advanced analytics;Algorithms;Anesthesia procedures;Anesthesiology;Area Under Curve;Benchmarking;Cardiac;Cardiac Surgery procedures;Cardiopulmonary Bypass;Caring;Characteristics;Chronic Kidney Failure;Clinical;Clinical Trials;clinically relevant;cohort;Communication;Complication;cost;Data;data infrastructure;Data Set;Data Sources;Databases;Dialysis procedure;EHR research;evidence base;Expenditure;Feedback;Future;Goals;Health Expenditures;Health system;Healthcare;hemodynamics;Hemoglobin;Heterogeneity;Hospital Societies;Hospitals;Hypotension;improved;Individual;individualized medicine;Infrastructure;Injury to Kidney;innovation;Intensive Care Units;Intervention;Intraoperative Care;Kidney;Knowledge;Liquid substance;Measures;member;Michigan;modifiable risk;mortality;Multicenter Studies;Natural experiment;Nurses;Operative Surgical Procedures;optimal treatments;Outcome;Oxygen;Pathology;Patient risk;Patients;Pattern;Patterns of Care;Performance;Perioperative;personalized approach;personalized care;Pharmaceutical Preparations;Physiological;Population;Postdoctoral Fellow;Postoperative Care;Postoperative Period;Precision therapeutics;predictive modeling;Procedures;Process;Provider;Records;Registries;Reporting;Research;Review Literature;Risk;Risk Adjustment;Risk Factors;Risk Reduction;Societies;Source;Standardization;standardized care;Techniques;Thoracic Surgeon;Translating;treatment as usual;treatment effect;treatment strategy;Universities;Update;Validation;Variant

PROJECT_TITLE: Cardiac sURgery anesthesia Best practices to reduce Acute Kidney Injury (CURB-AKI)


NIH_SPENDING_CATS: Biotechnology;Cancer;Skin Cancer

ORG_DEPT: PATHOLOGY

PHR: Project Narrative BRAF and MEK inhibitor therapies are often potent against melanoma, but patients nearly always eventually develop drug resistance. We have identified S6K1, an understudied drug target, as a potential broad-use counter-resistance therapy, as it can block most known resistance mechanisms. In this proposal, we will cement a role of S6K1 as a key drug target in melanoma by conducting extensive drug testing, examining its correlation with patient outcomes, and exploring the mechanisms of how S6K1 drives drug resistance.

PI_NAMEs: KWONG, LAWRENCE  (contact)

PROGRAM_OFFICER_NAME: FORRY, SUZANNE L

PROJECT_TERMS: acquired drug resistance;Address;Bioinformatics;Biological Models;Biopsy;BRAF gene;Cancer Model;CDK4 gene;Cell Cycle;Cell Cycle Arrest;cell growth;Cell Line;Cell model;Cell Proliferation;Cellular Metabolic Process;Cementation;Clinical;clinical application;Clinical Trials;clinically relevant;clinically significant;Collaborations;Combined Modality Therapy;Data;design;Development;Drug Controls;Drug Design;Drug resistance;drug resistance development;Drug Targeting;drug testing;Foundations;FRAP1 gene;Future;Genes;Genetic;Goals;Human;Immunohistochemistry;improved;in vivo;inhibitor;inhibitor therapy;Institution;knock-down;Link;MAP Kinase Gene;Mediating;MEKs;melanocyte;Melanoma;Melanoma Cell;Melanoma patient;melanomagenesis;Metabolic;Mitogen-Activated Protein Kinase Inhibitor;Modeling;mouse model;mutant;Mutation;next generation;NF1 mutation;novel;Oncogenic;Outcome;Pathway interactions;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;pharmacologic;PIK3CA gene;PIK3CG gene;pre-clinical;prevent;Productivity;Proteomics;Quality of life;Recording of previous events;Resistance;resistance mechanism;Ribosomal Protein S6 Kinase;Role;Sampling;Series;Signal Transduction;targeted treatment;Testing;Therapeutic;therapeutic target;Therapeutic Uses;Toxic effect;Treatment Efficacy;tumor initiation;tumorigenesis

PROJECT_TITLE: A Convergent Node in Melanoma to Block Multiple Oncogenic Pathways Simultaneously

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 2 Study Section[MCT2]


ADMINISTERING_IC: VA

FUNDING_MECHANISM: OTHERS

IC_NAME: Veterans Affairs

ORG_CITY: PITTSBURGH

ORG_NAME: VETERANS HEALTH ADMINISTRATION

PHR: Roughly 6 million people with a disability experience transportation difficulties as a result of the lack of accessible transportation, scheduling complications, high costs and limited availability for nonmedical purposes. According to the US Department of Transportation, some of the most common strategies to compensate include reducing day-to-day travel, asking others for rides, limiting travel to daytime and giving up driving. As a result, there is a significant demand for more accessible transportation options. Unfortunately, acquiring a personal accessible vehicle is financially difficult due to the extensive cost of the modifications that are necessary for power wheelchairs to fit, specifically. Although such modifications are able to be performed today, the convertibility of future electric vehicles raise additional design challenges due to the location of the batteries and electrical components.

PI_NAMEs: DAVELER, BRANDON  (contact)

PROJECT_TITLE: Simplified Accessible Vehicle and Robotic wheelchair

STUDY_SECTION_NAME: Career Development Program - Panel I[RRD8]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Neurosciences;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: PROVIDENCE

ORG_NAME: BUTLER HOSPITAL (PROVIDENCE, RI)

ORG_STATE: RI

PHR: NARRATIVE Early initiators of buprenorphine, a leading treatment for opioid use disorder, are at high risk for early relapse, likely due to dysfunction within craving and cognitive control neuronal networks. This project will test a non- invasive brain stimulation technique, transcranial Direct Current Stimulation, to reduce craving in buprenorphine recipients. If the FMRI provides validation of tDCS-related changes in these neuronal networks as well as clinical efficacy, then this neuromodulation intervention may be an important adjuvant treatment in clinical care of those entering buprenorphine care.

PI_NAMEs: ABRANTES, ANA M (contact);STEIN, MICHAEL D

PROGRAM_OFFICER_NAME: RAMEY, TANYA S

PROJECT_TERMS: Abstinence;Acute;addiction;Address;Adjuvant Therapy;Aftercare;Anodes;behavior measurement;Brain;Buprenorphine;buprenorphine treatment;Caring;Cathodes;Clinical;clinical care;clinical efficacy;cognitive control;comparison intervention;Consumption;craving;Critiques;cue reactivity;Dropout;Drug Addiction;Drug usage;follow-up;Functional disorder;Functional Magnetic Resonance Imaging;functional MRI scan;Heroin Users;high risk;Impulsivity;Informal Social Control;Intervention;Left;Measures;Modeling;Motivation;neural;neurobehavioral;neuromechanism;Neurons;neuroregulation;noninvasive brain stimulation;Opioid;opioid epidemic;opioid use;opioid use disorder;opioid user;Outcome;overdose risk;Participant;Persons;Pharmaceutical Preparations;Phase;Population;portability;Prefrontal Cortex;Randomized;Relapse;Research Personnel;response;Rest;Rewards;Safety;Short-Term Memory;Substance Use Disorder;System;Techniques;Testing;transcranial direct current stimulation;treatment duration;Treatment Failure;treatment response;Validation;Withdrawal Symptom;Work

PROJECT_TITLE: tDCS to Decrease Opioid Relapse


PHR: OVERALL - NARRATIVE COVID-19 is a world-wide health problem caused by SARS-CoV-2 viral infection that starts in the lung but can also affect the heart, and brain. Our Program teams will join forces to better understand the mechanism of organ damage and reveal ways to prevent it by combining efforts of three Projects supported by four Cores. Working will simultaneously, synergistically and collaboratively complement, expedite and enhance the understanding of the mechanism of COVID-19-mediated damage in different organs to identify novel drug targets that can limit the severity of COVID-19 and the development of long-term sequalae.

PI_NAMEs: AMER, AMAL O (contact);CORMET-BOYAKA, ESTELLE A;LI, JIANRONG

PROGRAM_OFFICER_NAME: VAZQUEZ-MALDONADO, NANCY

PROJECT_TERMS: 2019-nCoV;Acute;adaptive immune response;Affect;Animal Model;Anti-viral Agents;Bioinformatics;Biological;Biological Markers;Biometry;Blood;Blood - brain barrier anatomy;Blood Circulation;Blood Coagulation Disorders;Blood specimen;Brain;brain circulation;Brain Pathology;Cardiac;Cardiovascular system;CASP4 gene;Caspase;cell injury;Cell Physiology;cell type;Cells;cellular targeting;Cerebrum;collaborative approach;Complement;COVID-19;COVID-19 patient;COVID-19 severity;COVID-19 treatment;cytokine;cytokine release syndrome;Derivation procedure;Development;Disease;Dose;emerging virus;Endothelial Cells;Enzymes;Event;Evolution;experience;experimental study;genetic manipulation;Goals;Health;Heart;Homologous Gene;Human;Immune;Immune response;Immune System Diseases;Immunity;immunothrombosis;Infection;Inflammasome;Inflammation;Inflammatory;Inflammatory Response;Innate Immune Response;insight;Knock-out;Knockout Mice;Lead;Long COVID;long-term sequelae;Lung;Maintenance;Mediating;member;Methods;Methyltransferase;Modeling;Mus;myelination;nanoparticle;Nervous System Disorder;neuroinflammation;new therapeutic target;novel;Organ;Outcome;pathogen;Pathogenicity;Pathology;Patients;Population;prevent;Production;programs;Pulmonary Pathology;Reaction;Reagent;Recording of previous events;Reporting;Respiratory Disease;response;restraint;RNA;Role;SARS-CoV-2 infection;Severity of illness;small hairpin RNA;Symptoms;Synaptic plasticity;Syndrome;synergism;Techniques;Testing;Therapeutic;therapeutic target;Thrombosis;Thrombus;Tissues;trafficking;transcriptomics;translational potential;unvaccinated;Vaccines;Variant;Viral;Viral Load result;viral rebound;viral resistance;Virus Diseases;Virus Replication;Wild Type Mouse

PROJECT_TITLE: Role of the Non-canonical Inflammasome in SARS-CoV-2-mediated Pathology and Coagulopathy

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 KLM-I (J1)]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Coronaviruses;Emerging Infectious Diseases;Hematology;Infectious Diseases;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID

PI_NAMEs: AMER, AMAL O (contact)

PROJECT_TERMS: 2019-nCoV;Adaptive Immune System;Administrative Coordination;Administrative Personnel;Blood Coagulation Disorders;Caspase;Cell Physiology;Collaborations;Communication;conflict resolution;Contracts;Data;data management;data sharing;design;Development;distraction;Doctor of Philosophy;Elements;Ensure;Environment;Equipment;Fostering;Goals;Grant;Infectious Agent;Inflammasome;Inflammation;Innate Immune System;Investigation;Lead;Leadership;Long COVID;Maintenance;Manuscripts;Mediating;Medical center;meetings;member;Morbidity - disease rate;mortality;mouse model;Natural Immunity;Occupational activity of managing finances;Office of Administrative Management;Organ;Pathology;Pathway interactions;Pediatric Hospitals;preservation;Productivity;programs;Protocols documentation;Publishing;Quality Control;Reagent;Research;Research Project Grants;Resources;response;Role;Sampling;SARS-CoV-2 infection;severe COVID-19;Statistical Data Interpretation;Structure;Thrombosis;transcriptome sequencing;United States National Institutes of Health;Veterinary Schools;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Coronaviruses;Data Science;Emerging Infectious Diseases;Hematology;Infectious Diseases

PI_NAMEs: ZHANG, XIAOLI  (contact)

PROJECT_TERMS: 2019-nCoV;Address;Bioinformatics;Biological;biomarker discovery;biomedical informatics;Biometry;Blood Coagulation Disorders;Cells;Clinical;Collaborations;Communities;complex data;computerized data processing;Data;Data Analyses;Data Collection;data exploration;data integration;data integrity;data management;data quality;data sharing;design;Ensure;experience;Experimental Designs;experimental study;Formulation;Genes;Goals;high dimensionality;Human Resources;Inflammasome;informatics shared resource;Investigation;Knowledge;laboratory experiment;Maintenance;Measurement;Mediating;meetings;member;Methodology;Methods;Modeling;Multiomic Data;next generation sequencing;novel;Outcome Measure;Paper;Pathology;pre-clinical;primary outcome;Procedures;programs;Publishing;Quality Control;Reporting;repository;Research;Research Design;Research Personnel;Resources;Role;Sample Size;Science;Scientist;Secure;Security;Services;Standardization;Statistical Data Interpretation;Statistical Models;Statistical sensitivity;success;Testing;transcriptome sequencing;translational study;Visual;Visualization;Work

PROJECT_TITLE: Biostatistics and Bioinformatics Core


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Genetics;Hematology;Infectious Diseases

PI_NAMEs: LI, JIANRONG  (contact)

PROJECT_TERMS: 2019-nCoV;adaptive immunity;Anesthesia procedures;Animal Model;animal tissue;Animals;Biological;Biological Assay;Biological Sciences;biosafety level 3 facility;Biostatistics Core;Blood;Blood Coagulation Disorders;Body Weight Changes;Brain;Breeding;bronchial epithelium;Caspase;Caspase Inhibitor;Cells;Collaborations;college;COVID-19 therapeutics;cytokine;design;Detection;efficacy testing;Ensure;Enzyme-Linked Immunosorbent Assay;Epigenetic Process;Euthanasia;expectation;experimental study;Genetically Engineered Mouse;Genome;Genotype;Goals;Hamsters;Heart;Histology;Human;human disease;Immunohistochemistry;improved;In Vitro;in vivo;Infection;Inflammasome;Inflammatory;Inflammatory Response Pathway;instrumentation;Isoflurane;Kidney;Knockout Mice;Lead;Liver;LoxP-flanked allele;Lung;Mediating;Mesocricetus auratus;Methyltransferase;Modeling;Modification;Molecular;mouse genome;Mus;Nasal turbinate bone structure;Natural Immunity;Nose;Ohio;Organ;Pathology;Plaque Assay;post SARS-CoV-2 infection;Procedures;Program Research Project Grants;programs;Qualifying;quality assurance;Reagent;Recombinants;Reproducibility;Research Personnel;Research Project Grants;respiratory virus;RNA;Role;SARS-CoV-2 B.1.1.529;SARS-CoV-2 B.1.617.2;SARS-CoV-2 infection;SARS-CoV-2 variant;Services;Standardization;Symptoms;Testing;Therapeutic Agents;Therapeutic Effect;Tissue Extracts;Titrations;Transgenic Organisms;Universities;variants of concern;Veterinarians;Veterinary Medicine;Viral Genome;Viral Load result;virology;Virus

PROJECT_TITLE: Biological Reagents and Infection Core


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Hematology;Infectious Diseases;Lung;Neurosciences;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID

PI_NAMEs: CORMET-BOYAKA, ESTELLE A (contact)

PROJECT_TERMS: 2019-nCoV;3-Dimensional;adaptive immunity;Affect;airway epithelium;Astrocytes;Basal Cell;Biology;Blood;Blood - brain barrier anatomy;Blood Coagulation Disorders;Blood Platelets;Blood specimen;Brain;brain cell;brain fog;brain tissue;bronchial epithelium;Cadaver;CASP4 gene;Caspase;Cell Culture Techniques;Cell Line;Cell Separation;cell type;Cells;chemokine;Clinical;COVID-19;COVID-19 pathogenesis;COVID-19 patient;COVID-19 treatment;CRISPR/Cas technology;Cystic Fibrosis;cytokine;cytokine release syndrome;Data;Derivation procedure;Endothelial Cells;Endothelium;Epithelial Cells;experimental study;Foundations;Funding;Gene Modified;Goals;Health;Human;Immune;Individual;Inflammasome;Inflammation;Injury;Knockout Mice;Knowledge;Lead;Long COVID;Lung;Lymphocyte;Macrophage;Maintenance;Mediating;Microglia;monocyte;mouse model;Mucins;Mus;Neurologic Symptoms;Neurons;neutrophil;new therapeutic target;Organ;pandemic disease;Pathology;Pathway interactions;Patients;Persons;Pharmaceutical Preparations;prevent;Program Development;programs;Quantitative Reverse Transcriptase PCR;Reporting;research and development;Research Personnel;Resources;RNA;Role;Sampling;SARS-CoV-2 infection;Site;Structure of parenchyma of lung;Symptoms;Thrombosis;transcriptomics;Translating;Virulence;Virus;von Willebrand Factor

PROJECT_TITLE: Cell Derivation and Maintenance Core


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Immunization;Immunotherapy;Infectious Diseases;Lung;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID;Prevention;Vaccine Related

PI_NAMEs: BOYAKA, PROSPER N (contact)

PROJECT_TERMS: 2019-nCoV;acute COVID-19;adaptive immune response;adaptive immunity;Affect;Antibodies;B-Lymphocytes;Bacterial Infections;Blood Coagulation Disorders;Blood specimen;Brain;Cardiovascular Diseases;CASP4 gene;Caspase;Cell Death;cell motility;Cell Physiology;Cells;Cessation of life;Clinical;COVID-19;COVID-19 patient;COVID-19 treatment;COVID-19 vaccine;cytokine;cytokine release syndrome;Data;Development;Diabetes Mellitus;Disease;Disease Outcome;Endothelium;Ensure;Environment;Exhibits;Future;Gastrointestinal Diseases;Gastrointestinal tract structure;Generations;Goals;Height;Hematology;Hospitalization;Human;Immune;immune activation;immune checkpoint;Immune response;Immune system;Immunity;Immunoglobulin A;Impairment;improved;Infection;Infectious Agent;Inflammasome;Inflammation;Inflammatory;Inflammatory Response;Innate Immune Response;Kidney Diseases;Knockout Mice;Long COVID;Lung;lung injury;Lymphoid Tissue;Measures;Mediating;member;Mental Health;Molecular;mortality risk;mouse model;Mucosal Immunity;Mucous Membrane;Multiple Organ Failure;Mus;Musculoskeletal Diseases;nasal swab;Nasopharynx;Nature;Neurologic;novel therapeutic intervention;Organ;pandemic disease;pathogen;Pathology;Pathway interactions;Patients;Persons;Play;post SARS-CoV-2 infection;prevent;Production;Prognosis;programs;Pulmonary Pathology;Relaxation;Reporting;respiratory;response;Risk;RNA;Role;SARS-CoV-2 antibody;SARS-CoV-2 immunity;SARS-CoV-2 infection;SARS-CoV-2 variant;Sepsis;severe COVID-19;Severities;Severity of illness;Shapes;Site;stem;Structure of parenchyma of lung;Symptoms;Syndrome;T cell response;T-Lymphocyte;Testing;Thrombosis;Tissues;transcriptome sequencing;Transferase;transmission process;Travel;vaccine development;Vaccinee;Vaccines;variants of concern;Viral;Viral Load result;viral transmission;Virus;Virus Replication

PROJECT_TITLE: Role of CASP-11 in SARS-CoV-2-induced lung pathologies and long-term immune protection


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Genetics;Hematology;Infectious Diseases;Lung;Neurosciences;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID

PROJECT_TERMS: 2019-nCoV;Acute;adaptive immunity;Blood - brain barrier anatomy;Blood Cells;Blood Circulation;Blood Coagulation Disorders;Blood specimen;Blood Vessels;Body Weight decreased;Brain;brain fog;Brain Pathology;CASP4 gene;Caspase;Cell Death;Cell Migration Pathway;cell motility;Cell Physiology;cell type;Cells;Cerebrum;Cessation of life;Code;Collaborations;Complement;COVID-19;COVID-19 pandemic;COVID-19 patient;cytokine;cytokine release syndrome;Data;design;Development;Disease;Endothelial Cells;Fibrin fragment D;Fibrin split products;Gastrointestinal tract structure;Gene Expression;Genes;Goals;Headache;Health;Human;Immune;immunothrombosis;improved;Individual;Infection;Inflammasome;Inflammation;inhibitor;Innate Immune System;Knockout Mice;Liver;Long COVID;Lung;Lung infections;Lymphocyte;Mediating;member;Mus;Myelin;nasal swab;Neuroglia;neuroinflammation;Neurons;new therapeutic target;novel;Pathogenicity;Pathology;Pathway interactions;Patients;Persons;Phase;prevent;Production;programs;Pulmonary Inflammation;Resolution;response;RNA;Role;SARS-CoV-2 infection;Sepsis;severe COVID-19;Severity of illness;single-cell RNA sequencing;Survivors;Symptoms;Synapses;synergism;T cell response;Testing;therapeutic target;Thromboplastin;Thrombosis;Thrombus;Tissues;transcriptome sequencing;transcriptomics;Viral Load result;Virus;von Willebrand Factor;Wild Type Mouse

PROJECT_TITLE: Caspr/11-dependent immunothrombosis and neuroinflammation during SARS-CoV-2 infection


PROJECT_TERMS: 2019-nCoV;adaptive immune response;adaptive immunity;Anti-viral Therapy;Antibodies;Binding;Biological Process;Blood Coagulation Disorders;bronchial epithelium;CASP4 gene;Caspase;Cells;Cessation of life;Clinical Trials;COVID-19;COVID-19 cytokine storm;COVID-19 pandemic;COVID-19 patient;COVID-19 treatment;CRISPR/Cas technology;cytokine release syndrome;Data;Development;Disease;effective therapy;Enzymes;Epigenetic Process;Escape Mutant;Exposure to;Gene Expression;Goals;High-Throughput RNA Sequencing;Human;improved;In Vitro;in vivo;Inflammasome;inhibitor;Innate Immune Response;knock-down;Knock-out;Knockout Mice;Maps;Mediating;member;Methylation;Methyltransferase;Modification;Multiple Organ Failure;Mus;nanoparticle;Natural Immunity;new therapeutic target;novel;obligate intracellular parasite;Organ;Outcome;Pathogenesis;Pathology;Pharmaceutical Preparations;Play;Post-Translational Protein Processing;Process;Proteins;Pseudouridine;Pulmonary Pathology;Reader;RNA;RNA metabolism;RNA purification;RNA-Binding Proteins;Role;S-Adenosylhomocysteine;S-Adenosylmethionine;SARS-CoV-2 infection;SARS-CoV-2 inhibitor;SARS-CoV-2 variant;Series;severe COVID-19;Site;small hairpin RNA;Small Interfering RNA;small molecule inhibitor;Techniques;Therapeutic;Therapeutic Effect;Translations;variants of concern;Viral;Viral Load result;viral RNA;Virus;Virus Replication

PROJECT_TITLE: CASP-11-dependent RNA modifications and their Role in Multi-Organ Pathologies


ORG_CITY: DURHAM

ORG_NAME: DURHAM VA MEDICAL CENTER

ORG_STATE: NC

PHR: PROJECT NARRATIVE. Persons with functional disabilities overwhelmingly prefer to remain at home. Home and Community-Based Services (HCBS) are an important support to help Veterans age in place, but government reports reveal HCBS access barriers for qualifying Veterans and show 50% of Veterans referred to HCBS do not use services within 12 months. We do not understand how supply constraints such as lack of access versus demand constraints such as preferences affect HCBS use nationally, nor the consequences of use patterns for Veteran-centered outcomes. This rigorous mixed methods study will illuminate multi-level drivers of the largest VA HCBS, homemaker home health aide services (H/HHA). We will also estimate the average treatment effect of H/HHA on Veteran-centered outcomes and total VA costs. This IIR will inform future scalability of H/HHA by obtaining perspectives from multiple parties about suboptimal use and use implementation mapping with our operational partners to recommend actionable change to the H/HHA benefit.

PI_NAMEs: HASTINGS, SUSAN NICOLE (contact)

PROJECT_TERMS: Acceleration;Activities of Daily Living;Address;Administrator;Affect;Aging;aging in place;Ambulatory Care Facilities;Area;Budgets;care coordination;care costs;Caregivers;Caring;Climate;Clinic;Clinical;clinical care;Communities;community based service;community partnership;Contracts;cost;Disabling;distrust;Elderly;Employee;Event;Exposure to;Face;fall injury;functional disability;Funding;Future;Government;Health Services Accessibility;Healthcare Systems;Home;Home Health Agency;Home Health Aides;Home Nursing Care;homing gene drive;improved;injured;Institution;Institutionalization;Interview;Knowledge;Laws;Learning;Light;Long-Term Care;Maps;Methods;Modeling;multiple disability;Nursing Homes;Outcome;patient home care;Pattern;person centered;Persons;Policies;Population Heterogeneity;post 9/11;Predictive Factor;preference;primary care provider;Process;Provider;Qualifying;Quality of life;Recommendation;referral services;Reporting;Role;Route;service programs;Services;Site;Social Workers;Structure;Thinness;Time;treatment effect;uptake;Veterans;Waiting Lists

PROJECT_TITLE: Homemaker Home Health Aide Use and Veteran-Centered Outcomes

STUDY_SECTION_NAME: HSR-6 Aging, Recovery, and Workforce[HSR6]


ORG_CITY: CANANDAIGUA

ORG_NAME: VETERANS AFFAIRS, UNITED STATES DEPARTMENT OF

ORG_STATE: NY

PHR: By the year 2037, Veterans’ use of Community Nursing Homes will increase 80% above 2017 levels, and corresponding expenditures will increase approximately 150%. Medical Foster Home (MFH) care is potentially less expensive. VA planning regarding MFH retention and expansion requires understanding the cost implications of MFH care. Because program coordinators are essential to MFH operations, to provide a cost saving alternative to institutional care, it is important to understand coordinator impact on efficiency of operations. This project will determine the impact of coordinator effort and experience on MFH Veteran direct healthcare costs as well as ED visits and hospitalizations. Additionally, to be a high reliability organization, the VA emphasizes the development of a patient safety culture among its facilities. This project will determine whether a patient safety culture moderates the impact of coordinators on program efficiency and will inform decisions regarding program coordinator coverage and training as impacted by patient safety culture.

PI_NAMEs: INTRATOR, ORNA K. (contact)

PROJECT_TERMS: Acute;Address;Age;Aging;Benchmarking;care costs;caregiver education;Caregiver support;Caregivers;Caring;cohesion;Communication;Communities;cost;Cost Savings;Data;Data Files;Data Set;data warehouse;Day Care;Dedications;Development;Dimensions;Direct Costs;Emergency department visit;Emergency Situation;Evaluation;expectation;Expenditure;experience;foster home;Foster Home Care;Geriatrics;Goals;Health Care Costs;health care service utilization;Healthcare;Home;Home environment;Home Nursing Care;Homogeneously Staining Region;Hospitalization;hospitalization rates;Hour;improved;innovation;Institution;Institutionalization;Licensing;Long-Term Care;Marketing;Medical;Medical Care Costs;Medicare/Medicaid;Methodology;Methods;military veteran;Monitor;Nursing Homes;operation;Outcome;patient oriented;patient safety;Patient Self-Report;Primary Care;primary care services;primary outcome;Privatization;program costs;Program Efficiency;programs;Publications;Research;residence;Resources;Risk;risk mitigation;Role;Running;Safety;Savings;secondary outcome;Surveys;Training;Trust;Variant;Veterans;Work

PROJECT_TITLE: Evaluating the Impact of Medical Foster Home Coordinator Effort and Experience on Costs


PHR: Drug manufacturers regularly introduce novel, resource-intensive treatments. There is a critical need and opportunity to optimize treatment with established medications to maximize their benefit and provide high- quality care considering competing VHA resources and Veterans’ needs. This challenge is exemplified in the treatment of inflammatory bowel disease (IBD), a costly and debilitating lifelong disease with rising resource needs. IBD represents an ideal proof-of-concept and real-world example on which to conduct research to address: 1. Patient-centered treatment optimization by putting VA Data to Work for Veterans, 2. Pre- implementation strategies for adoption, and 3. Optimal approaches to healthcare utilization (e.g., access to care) using the VA as a Learning Healthcare System–all of which are VA HSR&D Priorities, updated 3/2023. This work will serve as a template for positioning Artificial Intelligence (AI)/Machine Learning (ML)-enabled decision support strategies (AEDS) at the point of care to improve health outcomes and access for Veterans.

PI_NAMEs: HOU, JASON KEN;WALJEE, AKBAR K (contact)

PROJECT_TERMS: Address;Adopted;Adoption;Adrenal Cortex Hormones;Adverse event;Affect;American;Artificial Intelligence;Automobile Driving;Back;Behavioral;Benchmarking;Biological;Biological Products;care seeking;Caring;Characteristics;Chronic;Clinical;clinical decision support;clinical decision-making;Clinical Practice Guideline;cohort;Combined Modality Therapy;Communities;cost;COVID-19 pandemic;Crohn's disease;Data;data to knowledge;data warehouse;Decision Making;Decision Support Systems;Diagnosis;Disease;Dose;drug development;effectiveness evaluation;Electronic Health Record;Face;Goals;Health;health care service utilization;Health Services Accessibility;Health system;Healthcare;Healthcare Systems;Hospitalization;Immune;immunosuppressed;Immunosuppression;Immunosuppressive Agents;Impact evaluation;implementation strategy;improved;Inflammatory Bowel Diseases;Infusion procedures;innovation;Interview;Knowledge;Leadership;Learning;Machine Learning;machine learning algorithm;machine learning method;machine learning model;machine learning prediction;male;Manufacturer;Measurement;Mediating;Medication Systems;member;Methodology;model development;Modeling;Modernization;novel;Operative Surgical Procedures;Outcome;outpatient programs;patient oriented;Patients;Performance;persistent symptom;personalized approach;Pharmaceutical Preparations;point of care;Policies;Policy Analysis;Positioning Attribute;pragmatic trial;predictive modeling;prospective;Provider;Psychological reinforcement;Quality of Care;Research;Resources;Risk;Services;Specialist;Steroids;stressor;Structure;System;Techniques;Technology;theories;therapy development;thiopurine;Time;TNF gene;treatment as usual;treatment guidelines;treatment optimization;treatment response;Ulcerative Colitis;United States Health Resources Administration;Update;uptake;usability;Veterans;Veterans Health Administration;Wait Time;Work

PROJECT_TITLE: A learning health system approach to using Artificial Intelligence Enabled Decision Support (AEDS) for medication optimization in Veteran Care: An Immunosuppressants use case

STUDY_SECTION_NAME: HSR-3 Healthcare Informatics[HSR3]


ORG_CITY: CLEVELAND

ORG_NAME: LOUIS STOKES CLEVELAND VA MEDICAL CENTER

PHR: Individuals with paralysis represent a significant portion of the Veterans patient base. Paralysis reduces the ability to perform tasks of everyday living and can result in secondary health impacts (bone density loss and muscle atrophy) and a withdrawal from work and social activities. Powered exoskeletons are wearable robots that enable individuals with paralysis to walk again and exercise their paralyzed limbs. Although exoskeletons are safe for use in rehabilitative or home environments with trained caregivers, this CDA-1 proposal aims to explore falling with an exoskeleton and to reconfigure them into lower joint impact configurations to reduce potential injury to users if a fall should occur. Developing these features will amplify the health benefits of exoskeletons being prescribed for Veterans with paralysis by allowing more widespread and spontaneous use to encourage users to strengthen their muscles, improve their overall health, return to work, and become more actively engaged within their communities.

PI_NAMEs: HNAT, SANDRA  (contact)

PROJECT_TERMS: 3-Dimensional;Accidents;Activities of Daily Living;Address;Algorithms;Ankle;Award;base;Bionics;Bone Density;caregiver education;Caregivers;Classification;classification algorithm;Clinical Research;Communities;Computer software;Crutches;Data;design;Development;Devices;Elbow;Environment;Equilibrium;Exercise;exoskeleton;experience;Experimental Designs;experimental study;Fall prevention;falls;Floor;Funding;gait rehabilitation;Goals;Head;Health;Health Benefit;Hip region structure;Home;Home environment;Human;Hybrids;improved;improved mobility;Incidence;Individual;Injury;instrument;instrumentation;Intervention;Joints;kinematics;Knee;Laboratory Study;Lead;Learning;Limb structure;Location;long bone;male;Marketing;Measures;Medical center;Mentors;Methods;Modeling;Monitor;Motion;Motor;Muscle;Muscle Tonus;Muscular Atrophy;Musculoskeletal;Neck;Neurologic;neuroprosthesis;Outcome;Pain;Paralysed;Paraplegia;Participant;Patients;Positioning Attribute;Posture;powered exoskeleton;Powered wheelchair;prevent;Quality of life;Rehabilitation therapy;Reporting;Research;Research Personnel;response;Risk;Robot;Robotics;Safety;Secondary to;Series;Severities;Shoulder;simulation;social;spasticity;Speed;Spinal cord injury;Statistical Data Interpretation;System;Technology;technology platform;Testing;Time;Torque;Training;treadmill;United States;user protection;Variant;Veterans;volunteer;walker;Walking;wearable device;Withdrawal;Work;Wrist

PROJECT_TITLE: Investigating Fall Mitigation Strategies when Walking with an Exoskeleton for Users with Lower-Limb Paralysis


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Maternal Health;Maternal Morbidity and Mortality;Mental Health;Neurosciences;Opioid Misuse and Addiction;Opioids;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prescription Drug Misuse;Substance Misuse;Women's Health Research

ORG_CITY: BALTIMORE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: PROJECT NARRATIVE The current proposal examines how exposure to prescription opioids during pregnancy affects postpartum mental health and motivation for drug rewards. Oxytocin and dopamine signaling interactions are an at-risk substrate for the pharmacological actions of opioids during pregnancy. Using a combination of behavioral, neuroeconomic, optogenetic, and electrophysiological methods, this project seeks to reveal a causal link between prescription opioid use during pregnancy and postpartum opioid abuse risk, one of the main preventable causes of pregnancy-related deaths in the United States.

PI_NAMEs: LUJAN PEREZ, MIGUEL ANGEL  (contact)

PROGRAM_OFFICER_NAME: LIN, YU

PROJECT_TERMS: abuse liability;Adolescence;Affect;Attention;Behavior;Behavioral;behavioral economics;Birth;Brain;brain circuitry;Caring;Cells;critical period;Cues;design;Development;Dopamine;drug abuse vulnerability;drug reward;Drug usage;Economic Models;Electrophysiology (science);Endocrine;endogenous opioids;Epidemiology;Exhibits;experience;experimental study;Exposure to;Female;Fiber;genetic approach;Goals;Hypothalamic structure;Image;in utero;in vivo;Incentives;Institution;Lactation;Late pregnancy;Learning;Life;Link;Maternal Mortality;Mediating;Mental disorders;Mental Health;Mentors;mesolimbic system;Methods;Modeling;Mothers;Motivation;Mus;neural;neural circuit;neurobehavioral;neurobiological mechanism;Neurobiology;neuroeconomics;neuronal excitability;Neurons;Neuropeptides;Neurotransmitters;novel;Nulliparity;offspring;opiate tolerance;Opioid;opioid abuse;opioid exposure;Opioid Receptor;opioid use;opioid use in pregnancy;optogenetics;Outcome;outcome prediction;Overdose;overdose death;Oxycodone;Oxytocin;Oxytocin Receptor;patch clamp;Pathway interactions;Pharmaceutical Preparations;Pharmacologic Actions;Phase;Photometry;Postpartum Period;postsynaptic;Pregnancy;pregnancy related death;Pregnant Women;prescription opioid;Process;pup;Reinforcement Schedule;remifentanil;Research;Research Proposals;response;reward processing;Rewards;Risk;Risk Factors;Role;Self Administration;Signal Transduction;Stimulus;Structure;Substance abuse problem;Sucrose;Synapses;Time;tool;Training;United States;Ventral Tegmental Area;virus genetics;Work

PROJECT_TITLE: Postpartum Neurobiological Sequelae of Prescription Opioid Use During Pregnancy

STUDY_SECTION: NIDA

STUDY_SECTION_NAME: Career Development Education and Training Study Section[NIDA-K]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Genetics;Infectious Diseases;Microbiome

ORG_CITY: Newark

ORG_DEPT: DENTISTRY

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: Project Narrative Biofilms are a great risk to human health and since exopolysaccharide plays a major role in biofilms, understanding the regulation of its synthesis is a major goal of this project. Specifically, we will study the regulation of exopolysaccharide synthesis in the oral bacterium, Aggregatibacter actinomycetemcomitans, which is a major agent associated with Localized Aggressive Periodontitis. This disease primarily affects young adolescents of African American ancestry.

PI_NAMEs: CUGINI, CARLA ;RAMASUBBU, NARAYANAN  (contact)

PROGRAM_OFFICER_NAME: MCNEALY, TAMARA L

PROJECT_TERMS: Acceleration;Actinobacillus actinomycetemcomitans;Adherence;Adolescent;Aerobic;Affect;African American;African ancestry;Animal Model;anti-microbial tolerance;Bacteria;Binding;Biological Assay;Biology;Biotinylation;bone;bone loss;Carbon;Cell Survival;Chemotaxis;Complement;Confocal Microscopy;Data;Disease;Dose;Dot Immunoblotting;dysbiosis;Energy consumption;Environment;environmental change;Epithelium;Escherichia coli;fitness;Fumarates;Future;Gene Expression Profiling;gene synthesis;Genes;Genetic;Genetic Transcription;Genome;genomic locus;Genus staphylococcus;Goals;Growth;Health;histidine-rich proteins;Human;Immunofluorescence Immunologic;inhibitor;Knowledge;Libraries;Link;liquid chromatography mass spectrometry;Macrophage;Malates;Measures;Mediating;Membrane Proteins;metabolomics;Methods;Microbial Biofilms;mutant;novel;Oral;oral bacteria;oral microbial community;Organism;Pathogenesis;Pathway interactions;Periodicity;Periodontal Diseases;Periodontitis;Phagocytosis;Phenotype;Pilum;Play;Porphyromonas gingivalis;Positioning Attribute;premature;Process;Production;Proteins;quorum sensing;receptor;Regulation;Reporting;Respiration;Risk;Role;Second Messenger Systems;Signal Induction;Signal Transduction;Staphylococcus epidermidis;Succinate Dehydrogenase;Succinates;Surface;System;Tartrates;Testing;Tissue-Specific Gene Expression;Tissues;Tooth Loss;trait;Transcription Regulatory Protein;transcriptome sequencing;transposon sequencing;Virulence;Virulence Factors;Work;yeast two hybrid system

PROJECT_TITLE: Exopolysaccharide regulation in Aggregatibacter actinomycetemcomitans

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]


PHR: Over 1 million U.S. military Veterans identify as lesbian, gay, bisexual, transgender, non-binary, queer/questioning, and other sexual/gender minority identities (LGBTQ+). This is a growing group of Veterans in the Veterans Health Administration (VHA). LGBTQ+ Veterans have disproportionate risk of mental health concerns, such as depression and suicide. Little is known about the best ways to implement treatments that are designed to reduce mental health risk in LGBTQ+ individuals. This study would contribute to scientific knowledge about methods to include health equity in planning how to implement evidence-based mental health interventions for LGBTQ+ Veterans. This study would also contribute to scientific knowledge about how implementation of evidence-based, LGBTQ-affirmative mental health treatments can improve access to mental health care as well as depression and suicidality among LGBTQ+ Veterans.

PI_NAMEs: WILSON, SARAH MOSHER (contact)

PROJECT_TERMS: Adoption;Advocacy;Affect;Algorithms;arm;Attention;Behavior;Caring;Clinical Trials;clinically significant;Cluster randomized trial;Cognitive Therapy;cohort;Coin;Collaborations;Communities;community organizations;community partners;Consultations;depressive symptoms;Discrimination;Dissemination and Implementation;Documentation;Educational Intervention;Effectiveness;Effectiveness of Interventions;effectiveness outcome;effectiveness testing;effectiveness/implementation trial;Electronics;Equity;evidence base;Exploration, Preparation, Implementation, and Sustainment;Face;Fatigue;Funding;Health;health care service;health disparity;Health education;health equity;Homogeneously Staining Region;Hybrids;implementation barriers;implementation determinants;implementation facilitators;implementation outcomes;Implementation readiness;implementation science;implementation strategy;Improve Access;improved;Individual;informant;innovation;Intervention;Interview;Knowledge;Lesbian Gay Bisexual Transgender;Lesbian Gay Bisexual Transgender Queer;Manuals;Maps;Measurement;Measures;meetings;Mental Depression;Mental Health;Mental Health Services;Methodology;Methods;military veteran;Modeling;Natural Language Processing;nonbinary;operation;Outcome;Phase;Pilot Projects;Population;primary outcome;Process;programs;Provider;Qualitative Methods;queer;Randomized;Research;Risk;Sexual and Gender Minorities;Site;social stigma;Strategic Planning;suicidal;Suicide;suicide rate;Testing;therapy design;Thinking;Trainers Training;Training;trial design;uptake;Veterans;Veterans Health Administration;Work

PROJECT_TITLE: Equity-Focused Implementation of LGBTQ-Affirmative Cognitive Behavioral Therapy: A Hybrid Implementation-Effectiveness Trial

STUDY_SECTION_NAME: HSR-2 Behavioral, Social, and Cultural Determinants of Health and Care[HSR2]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Food Allergies;Infectious Diseases;Nutrition;Pediatric;Prevention;Tickborne Diseases;Vector-Borne Diseases

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PROJECT NARRATIVE Food allergy exerts substantial impact on affected individuals, their families, and society, including lifestyle limitations and reductions in quality of life. This application from the Vanderbilt University Medical Center (VUMC), will address the following goals: (1) establish the VUMC CoFAR CRC, which will rapidly implement and execute single site and multi-center clinical trials, with high quality and fidelity, focused on the prevention and management of patients with food allergy, supplemented by studies to better elucidate the mechanisms underlying food allergies; (2) develop and conduct a consortium-wide, multi-center, clinical trial to evaluate the comparative effectiveness of once weekly peanut feeding (low weekly peanut protein dose) versus thrice weekly peanut feedings (standard weekly peanut protein dose) in the prevention of peanut allergy in infants at high risk for the development of peanut allergy; and (3) to better understand the alpha-gal syndrome (AGS), specifically why some patients in tick-endemic areas develop clinically evident AGS after a bite, while others do not, and why the clinical expression of AGS is variable amongst patients and changes over time.

PI_NAMEs: BACHARIER, LEONARD B (contact);ROBISON, RACHEL GLICK

PROGRAM_OFFICER_NAME: DONG, GANG

PROJECT_TERMS: Academic Medical Centers;Address;Adolescent;Adult;Affect;Allergic;Allergy to peanuts;alpha-gal syndrome;Ambylomma americanum;Area;Bioinformatics;Biology;Biometry;Bite;career;Caring;Child;Clinical;clinical heterogeneity;clinical practice;Clinical Research;Clinical Trials;comparative effectiveness;Complex;Dedications;Development;Disease;Dose;Electronic Health Record;Elements;Environment;experience;Faculty;Family;feeding;Food;Food Hypersensitivity;Goals;high risk;high risk infant;Hypersensitivity;Immune System Diseases;Immunology;Individual;Infant;Infrastructure;innovation;Lead;Life Style;Meat;Morbidity - disease rate;Multi-Institutional Clinical Trial;National Institute of Allergy and Infectious Disease;next generation;Nurse Practitioners;Oral;Participant;Patients;Phenotype;Physicians;Play;Prevalence;Prevention;Primary Prevention;programs;Proteins;Quality of life;Reaction;Readiness;Research;Research Personnel;response;Risk;Risk Factors;Role;Science;Site;Societies;stem;symptomatology;Symptoms;Syndrome;synergism;Tennessee;tick bite;Ticks;Time;Translational Research;Work

PROJECT_TITLE: Vanderbilt University Medical Center (VUMC) CoFAR Clinical Research Center

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 PT-I (J2)]


NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Mental Illness;Neurosciences;Post-Traumatic Stress Disorder (PTSD)

ORG_DEPT: PSYCHIATRY

ORG_NAME: DUKE UNIVERSITY

PHR: NARRATIVE The goal of this administrative supplement is to support research training and mentoring for Ms. LeeAnne Tunstall in the post-baccalaureate category. A graduate of Virginia Tech in May 2023 with a B.S. in Psychology, she is interested in pursuing a research career with a PhD in Clinical Psychology. Ms. Tunstall’s research experience will be considerably enhanced by dedicated mentoring by the PI, intellectually stimulating scientific and clinical environment at Duke, formal and informal educational experiences, scientific research, presenting a poster at a national science conference, and peer networking opportunities with post- baccalaureate, graduate, and post-doctoral trainees at Duke and with international collaborators.

PI_NAMEs: MOREY, RAJENDRA A (contact);SCHMAAL, LIANNE

PROGRAM_OFFICER_NAME: TUMA, FARRIS KEITH

PROJECT_TERMS: Administrative Supplement;Amygdaloid structure;Arousal;Behavior;Brain;Brain imaging;career;Categories;Cerebellum;Clinical;clinical center;Clinical Psychology;cognitive neuroscience;cohort;comorbidity;Dedications;Diagnosis;Diagnostic;Doctor of Philosophy;education research;Environment;Equilibrium;experience;Exposure to;Fright;Functional Magnetic Resonance Imaging;Goals;Hallucinogens;Hippocampus;informal learning;interest;International;Knowledge;meetings;Mentors;Methods;Minor;neural;Neurobiology;neuroimaging;neuroregulation;Neurosciences;Neurosciences Research;parent grant;parent project;Patients;pediatric trauma;peer networks;Post-Traumatic Stress Disorders;Postbaccalaureate;Postdoctoral Fellow;posters;Productivity;Psychiatry;Psychology;Psychotherapy;Research;Research Project Grants;Research Support;Research Training;Rest;Sampling;Science;Severities;Sleep disturbances;Structure;symposium;Symptoms;System;Time;Translating;trauma exposure;Virginia

PROJECT_TITLE: Neurobiologically-Based Subtyping of Multi-Cohort Samples with MDD and PTSD Symptoms

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


ORG_NAME: PHILADELPHIA VA MEDICAL CENTER

PHR: PROJECT NARRATIVE Maintaining functional status, or the ability to perform daily activities, is central to older adults’ quality of life, health, and ability to remain independent. Identifying functional impairments is essential for clinicians to provide optimal care to older adults, and on a population level, understanding function can help anticipate service needs. Yet uptake of standardized measurement of functional status into patient care has been slow and inconsistent due to the burden posed by current tools. The purpose of the proposed QUERI Partnered Evaluation Initiative is to implement and evaluate a patient-centered, low-burden intervention to improve measurement of functional status in VA primary care settings nationally. We hypothesize that implementing this intervention will increase identification and improve management of functional impairment among older Veterans while providing key data to inform VHA strategic planning related to long-term services and supports.

PI_NAMEs: BROWN, REBECCA TYLER (contact);NICOSIA, FRANCESCA

PROJECT_TERMS: acute care;Address;Adoption;Age;Aging;aging in place;Bathing;Caregivers;Caring;Cessation of life;Clinical effectiveness;compare effectiveness;Data;data repository;design;Development;Education;Effectiveness of Interventions;effectiveness outcome;effectiveness testing;Electronic Health Record;Electronics;Eligibility Determination;Evaluation;evidence base;experience;Feedback;follow up assessment;formative assessment;frailty;Friends;Functional impairment;functional improvement;functional status;Funding;Future;Geriatrics;Health;Health Services Accessibility;Health system;high risk;Hospitalization;Hospitals;Hybrids;Impairment;implementation outcomes;implementation strategy;implementation/effectiveness;improved;innovation;Institutionalization;Intervention;Long-Term Care;Measurement;Measures;Medical center;Methodology;multi-component intervention;novel;older adult;older patient;Outcome;Patient Care;patient oriented;Patient Triage;Patients;Perception;Phase;pilot test;Population;Practical Robust Implementation and Sustainability Model;preference;pressure;prevent;Primary Care;primary care setting;primary care team;programs;Quality of life;Questionnaires;Randomized;Reporting;Risk;satisfaction;screening;secondary outcome;Services;Site;Skilled Nursing Facilities;Standardization;Sterile coverings;Strategic Planning;Surveys;System;Time;tool;trial design;uptake;Veterans

PROJECT_TITLE: A Partnered Evaluation to Improve Identification and Management of Functional Impairment and Frailty for Older Veterans in VA Primary Care