NIH_SPENDING_CATS: Diabetes;Kidney Disease

ORG_CITY: TAMPA

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF SOUTH FLORIDA

ORG_STATE: FL

PHR: Project Narrative Diabetes and its renal complications are becoming epidemic in the U.S. population. The central hypothesis of this proposal is that concentrations of agonists of protease-activated receptors (PARs) are increased under diabetic nephropathy conditions. Thus, the identification of mechanisms for the regulation of calcium flux in podocytes by PAR agonists, especially under pathological conditions, has clear clinical significance.

PI_NAMEs: PALYGIN, OLEG ;STARUSCHENKO, ALEXANDER  (contact)

PROGRAM_OFFICER_NAME: MARIC-BILKAN, CHRISTINE

PROJECT_TERMS: Address;Agonist;Albuminuria;antagonist;Apoptosis;Area;beta-arrestin;Blood Platelets;Blood Vessels;Calcium;cell motility;Cells;Chronic Kidney Failure;Chronic Kidney Insufficiency;Clinical;Clinical Research;clinically significant;Complications of Diabetes Mellitus;Cytoskeleton;Data;Development;Diabetes Mellitus;diabetic;Diabetic Nephropathy;Disease;Disease Progression;Endothelial Cells;Epidemic;Event;F2R gene;Family;FDA approved;Foot Process;G Protein-Coupled Receptor Signaling;G-Protein-Coupled Receptors;Generations;glomerular filtration;Glomerulonephritis;glomerulosclerosis;GTP-Binding Proteins;Homeostasis;Human;human disease;Hypertrophy;in vivo;Inflammatory;Injury;Injury to Kidney;innovation;insight;Insulin-Dependent Diabetes Mellitus;interest;Intervention;Kidney;Kidney Diseases;kidney fibrosis;Kininogenase;Mediating;member;Membrane;Modeling;Morphology;Mus;Myocardial Infarction;Non-Insulin-Dependent Diabetes Mellitus;novel;PAR-1 Receptor;Pathologic;Pathway interactions;Patients;Peptide Hydrolases;Permeability;Pilot Projects;Play;podocyte;Population;prospective;protein activation;Protein Kinase C;Proteinase-Activated Receptors;Proteins;Proteinuria;Prothrombin;Publishing;Rattus;receptor;Receptor Signaling;receptor-mediated signaling;Regulation;release of sequestered calcium ion into cytoplasm;Renal function;Research;rho;Risk;Role;Serine Protease;Severity of illness;Sex Differences;Signal Pathway;Signal Transduction;Streptozocin;Structure;Testing;Therapeutic;Thrombin;Thrombin Receptor;Type 2 diabetic;urinary;Urokinase

PROJECT_TITLE: Renal diabetic complications mediated by the PAR1 signaling in podocytes

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


ADMINISTERING_IC: HL

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Atherosclerosis;Cardiovascular;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Human Genome;Machine Learning and Artificial Intelligence;Prevention

ORG_CITY: PHILADELPHIA

ORG_COUNTRY: UNITED STATES

ORG_DEPT: GENETICS

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE Polygenic risk scores (PRS) combine genetic information across an individual’s genome to predict risk of disease. We believe that by using rare genetic variants, along with clinical, environmental, and social risk factors in addition to the PRS, we can improve the ability to predict an individual’s risk of disease. We will test our novel translational informatics methods on three types of cardiovascular disease. Using this approach for early screening will allow for the development of prevention strategies and reduction of cardiovascular morbidity and mortality.

PI_NAMEs: KIM, DOKYOON ;RITCHIE, MARYLYN D (contact)

PROGRAM_OFFICER_NAME: YARDEN, RONIT I

PROJECT_TERMS: Address;Adopted;African ancestry;Area;Atrial Fibrillation;biobank;cardiac muscle disease;Cardiomyopathies;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;Cardiovascular system;Clinical;clinical care;clinical decision support;clinical implementation;clinical risk;cohort;Complex;Coronary Arteriosclerosis;Data;data integration;deep learning model;design;Development;Disease;disorder prevention;disorder risk;DNA;Early Diagnosis;Early identification;early screening;effective therapy;Electronic Health Record;Electronic Medical Records and Genomics Network;Emerging Technologies;European ancestry;exome;Genetic;genetic information;Genetic Predisposition to Disease;Genetic Risk;genetic risk factor;genetic variant;Genome;genome-wide;Goals;Health Personnel;Heart failure;heart rhythm;high risk population;improved;Incidence;Individual;Informatics;innovation;Investigation;Life;Machine Learning;machine learning method;Mathematics;Medicine;Methods;Modeling;Morbidity - disease rate;mortality;non-genetic;novel;Phenotype;polygenic risk score;Precision Health;predictive modeling;pressure;Prevention;Prevention strategy;Preventive therapy;programs;prototype;Public Health;rare variant;Research;response;Risk;Risk Factors;risk prediction;risk prediction model;Scoring Method;social;social health determinants;statistics;Surveys;Testing;trait;Translating;translational impact;translational potential;Translations;Variant;Vascular Diseases;Veterans;whole genome

PROJECT_TITLE: Methods for Enhancing Polygenic Risk Prediction Models for Complex Disease

STUDY_SECTION: CDMA

STUDY_SECTION_NAME: Clinical Data Management and Analysis Study Section[CDMA]


ADMINISTERING_IC: HD

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Social Determinants of Health;Women's Health Research

ORG_CITY: ANN ARBOR

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE Adoption and use of mobile devices have each grown exponentially in the last decade and mounting evidence suggests that mobile devices may uniquely interfere with a parent’s ability to sensitively respond to their child’s cues. These sensitive interactions are especially important in infancy and for low-income families, creating the foundations for social-emotional development that last a lifetime. This proposal seeks to address gaps in knowledge by understanding how first-time, low-income mothers use mobile devices, and the potential associations of mobile device use with maternal wellbeing, infant regulation, and maternal-infant co-regulation, in order to ultimately promote the health of children in infancy and beyond.

PI_NAMEs: MUNZER, TIFFANY GRACE-CHUNG (contact)

PROGRAM_OFFICER_NAME: ESPOSITO, LAYLA E

PROJECT_TERMS: adaptive devices;Address;Adolescent;Adoption;Adult;Age;aged;Anxiety;Award;Behavioral;Buffers;Caregivers;caregiving;Categories;Cellular Phone;Characteristics;Child;Child Health;Child Rearing;Child Welfare;cohort;Communication;coping mechanism;critical developmental period;critical period;Cross-Sectional Studies;Cues;depressive symptoms;design;Development;Devices;digital;digital media;distraction;early childhood;Electronic Mail;emotion regulation;Emotional;Equation;Exhibits;experience;Exposure to;externalizing behavior;Face;Facebook;Family;Foundations;Frequencies;Goals;Growth;Habits;handheld mobile device;Health Promotion;High Prevalence;Hormonal;improved;infancy;Infant;Infant Behavior;Infant Care;Infant Development;Internet;Intervention;invention;Knowledge;Learning;Life;life span;Low income;lower income families;maternal wellbeing;Measures;media use;Mediating;Mentors;Methods;Modeling;motherhood;Mothers;multidisciplinary;Nature;negative affect;Parent-Child Relations;Parents;Participant;Pathway interactions;Pattern;pediatrician;Personal Satisfaction;Phenotype;portability;Postpartum Depression;programs;Psychosocial Stress;Recreation;Regulation;Reporting;Research;response;Role;Sampling;Shapes;social;social media;Stress;Testing;Textiles;therapy design;Time;Toddler;university student;Well in self;Work

PROJECT_TITLE: Longitudinal associations of maternal mobile device use and maternal-infant wellbeing

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Health, Behavior, and Context Study Section[CHHD-M]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Orphan Drug;Rare Diseases

ORG_DEPT: BIOCHEMISTRY

PHR: PROJECT NARRATIVE Cytochrome P450 (CYP) 11B1 and 11B2 synthesize cortisol and aldosterone respectively, with excesses resulting in Cushing’s disease and primary aldosteronism. Drug treatments for each disease are limited due to poor drug selectivity resulting from the high similarity between these enzymes. This proposal aims to define differences between CYP11B1 and CYP11B2 active sites and interactions with common redox partner adrenodoxin, advances that may facilitate more effective drug design.

PI_NAMEs: LOOMIS, CARA LORENE (contact)

PROGRAM_OFFICER_NAME: PILEGGI, ANTONELLO

PROJECT_TERMS: Active Sites;Adrenodoxin;Affinity;Aldosterone;Binding;Biochemical;Biological Assay;Cardiovascular system;Catalysis;Clinical;Complex;Cortodoxone;CYP11A1 gene;CYP11B1 gene;Cytochrome P450;Data;design;Development;Disease;Distant;Drug Design;Enzyme Interaction;Enzymes;FDA approved;Future;Goals;Human;Hydrocortisone;Hyperaldosteronism;Hypertension;Immunosuppression;improved;inhibitor;insight;Investigation;Kinetics;Ligand Binding;Ligands;Literature;Membrane;Metabolic;Mutagenesis;novel strategies;Outcome;Oxidation-Reduction;Pharmaceutical Preparations;Pharmacotherapy;Pituitary-dependent Cushing's disease;prevent;Proteins;Research;Roentgen Rays;Role;Sequence Homology;Structure;Structure-Activity Relationship;Surface;System;therapy design;Weight Gain

PROJECT_TITLE: Defining Structural and Functional Differences Between Cytochrome P450 11B1 and 11B2 Interactions with Redox Partner Adrenodoxin for Developing Cushing’s Disease and Primary Aldosteronism Treatments


NIH_SPENDING_CATS: Cardiovascular;Contraception/Reproduction;Hypertension;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Women's Health Research

ORG_CITY: AUGUSTA

ORG_NAME: AUGUSTA UNIVERSITY

ORG_STATE: GA

PHR: Preeclampsia is a devastating cardiovascular disease in pregnancy and despite decades of research the reasons that pregnant women develop preeclampsia are not well-understood and treatment options are limited. Clinical studies have long identified that the hormone leptin inappropriately increases in preeclampsia, and we recently showed that leptin induces hypertension, vascular dysfunction and adverse fetal outcomes, the characteristics of preeclampsia, in pregnant mice. The focus of our studies will be to understand why leptin increases in preeclampsia, and also, to investigate the vascular, placental and endocrine mechanisms via which leptin causes the adverse cardiovascular and fetal outcomes of preeclampsia, which may lead to better clinical therapeutics for this disease.

PI_NAMEs: FAULKNER, JESSICA L. (contact)

PROGRAM_OFFICER_NAME: VARAGIC, JASMINA

PROJECT_TERMS: Ablation;Address;adipokines;Adipose tissue;Angiogenesis Inhibitors;antagonist;Arteries;Blood Vessels;cardiometabolic risk;Cardiovascular Diseases;Cardiovascular system;Cells;Characteristics;Chronic;Clinical;clinical care;Clinical Research;cohort;Data;Disease;Elements;Endocrine;Endothelial Cells;endothelial dysfunction;Endothelial Growth Factors Receptor;Endothelin A Receptor;Endothelin-1;Endothelin-converting enzyme 1;Endothelium;Event;Female;fetal;Fetal Growth Retardation;Functional disorder;Future;Goals;Hormones;Human;Hypertension;improved;innovation;Ischemia;Knockout Mice;Knowledge;Leptin;leptin receptor;Link;Low Birth Weight Infant;Mediating;Mineralocorticoid Receptor;Mitochondria;mitochondrial dysfunction;Modeling;Mothers;mouse model;Mus;novel;Obesity;offspring;Outcome;Pathway interactions;Patients;Perfusion;Placenta;Plasma;pre-clinical;Pre-Eclampsia;preclinical study;Pregnancy;pregnancy disorder;pregnant;Pregnant Women;pressure;Production;Publishing;receptor;Receptor Activation;receptor expression;Receptor Signaling;Regulation;Reporting;Research;Resistance;Role;Severities;Stimulus;Symptoms;System;Testing;Therapeutic;Time;Tissues;tool;Uterus;Vascular Diseases;vascular endothelial dysfunction;Vascular Endothelial Growth Factor Receptor-1;Vascular Endothelial Growth Factors

PROJECT_TITLE: Regulation and role of leptin in preeclampsia

STUDY_SECTION: IVPP

STUDY_SECTION_NAME: Integrative Vascular Physiology and Pathology Study Section[IVPP]


NIH_SPENDING_CATS: Chronic Obstructive Pulmonary Disease;Lung

ORG_CITY: NEW YORK

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: Narrative. SOURCE (SPIROMICS Study of Early COPD Progression) is an NHLBI funded study of the early manifestations of chronic obstructive pulmonary disease (COPD) in young (30-55 years) individuals. Based on the knowledge that the small airway epithelium (SAE) is the earliest site of pathology of COPD, the focus of this ancillary proposal is to characterize the disordered biology associated with SAE differentiation in a subset of 100 SOURCE participants and correlate this dysfunction with the abnormal early COPD small airway phenotypes characterized in SOURCE. The goal is to identify biologic processes in the pathogenesis of the airway abnormalities in early COPD that could serve as future targets for therapeutic intervention.

PI_NAMEs: CRYSTAL, RONALD G (contact);KANER, ROBERT J;MEZEY, JASON G

PROGRAM_OFFICER_NAME: LU, QING

PROJECT_TERMS: Affect;Age;Air;airway epithelium;Ancillary Study;Basal Cell;biobank;Biological;Biological Markers;Biological Process;Biology;Bone Morphogenetic Proteins;Bronchoscopy;Cell Differentiation process;cell type;Cells;Cellular biology;Characteristics;Chronic Obstructive Pulmonary Disease;Clinical;Clinical Data;clinical phenotype;Data;design;Disease;Disease Progression;Functional disorder;Funding;Future;Gene Expression;Genes;Goals;Goblet Cells;Gold;Human;Hyperplasia;Image;Impairment;In Vitro;Individual;Institution;Knowledge;Lavage;Liquid substance;Mediating;Mediator;Metaplasia;Mucous body substance;National Heart, Lung, and Blood Institute;Natural regeneration;non-smoking;Observational Study;overexpression;Participant;Pathogenesis;Pathology;Pathway interactions;pharmacologic;Phenotype;Physiological;Physiology;prevent;Proteins;Questionnaires;receptor;Resources;RNA;Role;Sampling;Serum;Signal Pathway;Site;small airways disease;Smoker;Squamous Differentiation;Squamous Metaplasia;stem cell differentiation;stem cells;Structure;targeted treatment;Testing;Therapeutic Intervention;therapeutic target;transcription factor;Undifferentiated;Up-Regulation

PROJECT_TITLE: Ancillary SOURCE Study: Characterization of Small Airway Basal Cell Biology in Early COPD

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Cervical Cancer;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Infectious Diseases;Prevention;Sexually Transmitted Infections;Women's Health Research

ORG_CITY: KAMPALA

ORG_COUNTRY: UGANDA

ORG_FIPS: UG

ORG_NAME: MAKERERE UNIVERSITY WALTER REED PROJECT

PHR: PROTOCOL NARRATIVE The Makerere University Walter Reed Project (MUWRP) in partnership with the U.S. Military HIV Research Program (MHRP) proposes to implement CASCADE clinical trials in central Uganda as a UG1 Clinical Research Site. Leveraging MUWRP’s clinical research experience, resources and pluripotent infrastructure and resources, as well as MUWRP’s Comprehensive HIV/AIDS Prevention, Care and Treatment in Central Uganda (CARE) program; funded by U.S. President’s Emergency Plan For AIDS Relief (PEPFAR); MUWRP and MHRP investigators will: 1) support UG1 Research Bases to develop concepts and protocols by providing insight and input in study feasibility, clinical significance (with a local context), 2) efficiently accrue and retain participants for all clinical trials; and 3) provide operational leadership to clinical and research staff implementing protocols at selected study sites in Uganda. CASCADE clinical trials and activities conducted by MUWRP and MHRP (entitled ‘Implementing HIV/Cervical Cancer Prevention ‘CASCADE’ Clinical Trials in Uganda (CASCADE-UGANDA)) will generate invaluable evidence for novel interventions for CXCA screening and precancer treatment.

PI_NAMEs: MWESIGWA, BETTY  (contact)

PROGRAM_OFFICER_NAME: FRECH, MARIA SILVINA

PROJECT_TERMS: Ablation;Accreditation;Acetic Acids;Acquired Immunodeficiency Syndrome;Address;African;Age;aged;AIDS prevention;Area;Awareness;base;Cancer Burden;Cancer Intervention;cancer prevention;Cancer Prevention Intervention;carcinogenesis;Caring;cervical cancer prevention;Clinic;Clinic Visits;Clinical;Clinical Research;clinical research site;clinical trial protocol;Clinical Trials;Clinical Trials Network;clinically significant;Cohort Studies;Cold Therapy;Communities;community collaboration;community engagement;Community Networks;community organizations;comorbidity;Competence;Conduct Clinical Trials;Country;Development;Diagnostic Procedure;Diagnostic Reagent Kits;DNA;Education;Effectiveness;Emergency Situation;Ensure;Environment;Ethics;Excision;experience;Feasibility Studies;Funding;Goals;Good Clinical Practice;Guidelines;Health;Health care facility;Health Personnel;HIV;Human Papilloma Virus Vaccination;Human Papillomavirus;human subject protection;Imaging Techniques;Incidence;Infrastructure;insight;interest;International;Intervention;Laboratories;Leadership;Lesion;low and middle-income countries;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Military Personnel;Molecular;molecular marker;novel;Participant;participant retention;Perception;Phase;point of care;Policies;Pragmatic clinical trial;pragmatic trial;premalignant;Prevention strategy;Procedures;programs;Prospective Studies;protocol development;Protocols documentation;Ramp;recruit;Regulation;Research;Research Infrastructure;Research Personnel;Resource-limited setting;Resources;retention rate;rural setting;Sampling;scale up;Scientist;screening;Screening for cancer;Site;skills;social stigma;Standardization;Supervision;Techniques;Testing;Thermal Ablation Therapy;Training;Translating;Uganda;Universities;uptake;urban setting;Visual;Woman;Women's Group;women's prevention

PROJECT_TITLE: Implementing HIV/Cervical Cancer Prevention CASCADE Clinical Trials in Uganda (CASCADE UGANDA)


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Hepatitis;Immunotherapy;Liver Disease;Nutrition;Obesity

ORG_CITY: WORCESTER

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

ORG_STATE: MA

PHR: PROJECT NARRATIVE Metabolic liver disease, affecting one in four adults in the U.S. and up to 75% of obese individuals, includes nonalcoholic fatty liver (NAFL), where lipid deposition accounts for more than 5~10% of the liver’s weight, nonalcoholic steatohepatitis (NASH), where the liver develops inflammation and fibrosis, and insulin resistance. Our project focuses on liver-resident immune cells and their release of proteins that play a major role in metabolic liver disease, presenting an exciting new idea that interferon-γ signaling in liver macrophages and their release of pro-inflammatory cytokine interleukin-12 regulate insulin resistance in the liver and other surrounding cells during the NAFL progression to NASH. The long-term goal of our research is to understand the role of macrophages and cytokines in the pathogenesis of NAFL and NASH and identify new therapeutic targets to treat metabolic liver disease in humans.

PI_NAMEs: KIM, JASON K (contact)

PROGRAM_OFFICER_NAME: GARCIA, MARTHA

PROJECT_TERMS: 3D ultrasound;Acute;adaptive immunity;Adipose tissue;Adult;Affect;Attenuated;Biological Assay;cell type;Cells;Chronic;Coculture Techniques;Complex;cytokine;Data;Dendritic Cells;Dependovirus;Deposition;Development;Diabetes Mellitus;Diet;diet-induced obesity;Encapsulated;experimental study;Fatty Liver;FGF21 gene;fibroblast growth factor 21;fibrogenesis;Fibrosis;FOXO1A gene;gain of function;Glucans;Glucose Clamp;glucose metabolism;Goals;Hepatic;Hepatic Stellate Cell;Hepatocyte;High Fat Diet;Histologic;Histology;Human;Hyperinsulinism;IFNGR1 gene;Immune;Immunofluorescence Immunologic;Immunologics;Impairment;improved;In Vitro;in vivo;Inflammation;Inflammatory;Inflammatory Response;insulin receptor substrate 1 protein;Insulin Resistance;insulin signaling;Interferon Activation;Interferon Suppression;Interferon Type II;Interferons;Interleukin-10;Interleukin-12;Interleukin-12 therapy;intrahepatic;IRS2 gene;islet amyloid polypeptide;Knockout Mice;Kupffer Cells;Ligands;Link;Lipids;Liver;Liver diseases;Liver Fibrosis;liver inflammation;loss of function;Macrophage;Mediating;Mediator;Metabolic;Molecular;Molecular Profiling;Mus;Muscle;Myeloid Cells;Natural Immunity;Natural Killer Cells;new therapeutic target;non-alcoholic fatty liver;nonalcoholic steatohepatitis;novel;obese person;Obesity;obesogenic;p38 Mitogen Activated Protein Kinase;particle;Pathogenesis;Pathway interactions;Play;Proteins;Research;Role;Serum;Signal Transduction;single-cell RNA sequencing;Skeletal Muscle;Small Interfering RNA;System;T-Lymphocyte;Testing;Th1 Cells;therapeutic target;Time;Weight

PROJECT_TITLE: Role of Interferon-Gamma / Interleukin-12 Axis in Metabolic Liver Disease

STUDY_SECTION: POMD

STUDY_SECTION_NAME: Pathophysiology of Obesity and Metabolic Disease Study Section[POMD]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

PHR: The overarching mission of the Center for Social Capital (SoCa) is to bring together academic institutions, community-based organizations, and a diverse group of stakeholders to reduce cancer health inequities due to persistent poverty in New York City (NYC) by promoting multi-generational health. We will conduct two complementary projects that focus on novel interventions in persistent poverty communities aimed at two structural determinants of health—education and health care—in which the interventions aim to increase social capital among youth in school settings, and patient navigators in Federally Qualified Health Centers as a means to alleviate systemic inequities The SoCa Center will leverage capacity across geographically separate groups of persistent poverty census tracts in NYC to cultivate the next generation of investigators and develop sustainable Core infrastructure to achieve cancer health equity.

PI_NAMEs: MATTHEWS, ALICIA K;PHILLIPS, ERICA ;TAMIMI, RULLA M (contact);TERRY, MARY BETH

PROGRAM_OFFICER_NAME: HARDESTY, REBECCA ANNE

PROJECT_TERMS: Academic Medical Centers;Adult;Affect;Age;Area;Automobile Driving;Behavior;Black Populations;Cancer Burden;Cancer Center;Cancer Control;cancer education;cancer health disparity;Cancer health equity;cancer initiation;cancer risk;cancer therapy;Caribbean region;Caring;Cause of Death;Censuses;Cessation of life;Cities;cohesion;Collaborations;Communication;Communities;community engaged approach;community organizations;County;design;Disadvantaged;Discrimination;Disparity;Early Diagnosis;early onset;Early treatment;economic impact;Economics;Education;Educational Curriculum;Educational process of instructing;effectiveness testing;electronic health record system;Emotional;Enrollment;Ethnic Origin;ethnic segregation;Face;Faculty;Family;Family member;Federally Qualified Health Center;Financial Hardship;Generations;Geography;Health;health care service;Health education;health inequalities;Health Promotion;Health Sciences;Health system;Healthcare;Height;Hospitals;Household;Immigrant;Immigration;Incidence;Individual;Inequity;Infrastructure;Institution;Intention;Intervention;junior high school;Justice;Life Expectancy;low health literacy;Malignant Neoplasms;Measures;Mediating;Medical center;migration;minority communities;Mission;mortality;Neighborhoods;New York;New York City;next generation;novel;Outcome;patient navigation;patient navigator;patient portal;physical separation;Play;poor communities;Population;Poverty;Poverty Areas;premature;Premature Mortality;Presbyterian Church;prevent;programs;quitline;Race;racial disparity;racism;Randomized;Recording of previous events;Research;Research Methodology;Research Personnel;residential segregation;Resources;Role;Schools;science teacher;segregation;social;social capital;social cohesion;social determinants;Social Environment;social health determinants;Social Interaction;Social Justice;social stigma;Social support;structural health determinants;Structural Racism;Students;System;Testing;therapy design;Tobacco;Training Programs;Universities;Washington;Youth

PROJECT_TITLE: Center for SOcial CApital (SOCA): Promoting Multigenerational Health


ADMINISTERING_IC: DA

ED_INST_TYPE: OTHER SPECIALIZED SCHOOLS

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Prevention;Substance Misuse

ORG_CITY: CAMBRIDGE

ORG_DEPT: MISCELLANEOUS

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

PHR: Project Narrative Our academic program offers biomedical and neuroscience researchers working in the field of substance use disorders (SUDs) a first-of-its-kind, integrated curriculum on innovation, entrepreneurial problem solving and biomedical product development. Our program’s goal is to promote technological and commercial innovations for SUDs prevention, diagnosis and treatment.

PI_NAMEs: BREAZEAL, CYNTHIA  (contact)

PROGRAM_OFFICER_NAME: LUKACS, JESSICA MICHELLE

PROJECT_TERMS: Academia;academic program;Address;aspirate;Biological Sciences;Biomedical Technology;Charge;Clinical Research;cohort;commercialization;Communities;community building;community setting;Development;Diagnosis;Diagnostic;digital;disorder prevention;Drug Addiction;Drug Use Disorder;Education;Educational Activities;Educational Curriculum;Educational Models;empowerment;Entrepreneurship;Epidemic;Evaluation;Event;experience;Fostering;Future;Goals;Government;Growth;Industry;innovation;innovative technologies;Institution;Knowledge;Laboratories;Learning;Marketing;Mind;Neurosciences;new technology;online course;Outcome;peer;Persons;Pharmacotherapy;prevent;Prevention;Problem Solving;Process;product development;Program Sustainability;programs;Publishing;recruit;Research;Research Personnel;Resources;Scientist;Services;skills;Societies;Substance Use Disorder;substance use treatment;technological innovation;Technology;Training;Translational Research;Universities;web site;webinar

PROJECT_TITLE: Program on Entrepreneurship and Innovation for Biomedical Product Development (EI4BPD)


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Lung Cancer;Pediatric;Prevention;Social Determinants of Health;Tobacco;Tobacco Smoke and Health

PI_NAMEs: TAMIMI, RULLA M (contact)

PROJECT_TERMS: Address;Adult;Area;behavioral and social science;Biometry;Cancer Control;Cancer Control Research;cancer health disparity;Cancer health equity;cancer risk;career;career preparation;Caring;Communities;community engaged research;community organizations;Data Science;design;Development;digital divide;Economics;Education;Educational Curriculum;electronic health record system;Enrollment;Ensure;Environmental Science;Epidemiology;Evaluation;Family member;Federally Qualified Health Center;Feedback;Foundations;Future;Generations;Goals;Health;health care service;health disparity;Health education;health equity;health inequalities;Health Sciences;Health Services;Healthcare Systems;Heart;high risk behavior;higher education;Hospitals;implementation science;Individual;Inequity;Infrastructure;infrastructure development;innovation;Institution;Intention;Intervention;junior high school;Justice;Life Cycle Stages;Link;Low income;Malignant Neoplasms;Mathematics;Medical center;meetings;Mentors;Methods;Mission;Monitor;New York;New York City;next generation;novel;patient navigation;patient navigator;patient portal;Population;Poverty;Poverty Areas;Presbyterian Church;programs;Public Policy;quitline;Research;Research Methodology;Research Personnel;Resources;Risk Behaviors;Risk Factors;Risk Reduction;Schools;Science;science education;science teacher;Science, Technology, Engineering and Mathematics;Smoker;Smoking;Smoking Cessation Intervention;social capital;structural health determinants;Students;synergism;System;Testing;Tobacco;Tobacco Use Cessation;Training;Universities;Youth

PROJECT_TITLE: Administrative Core


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: NARRATIVE – OVERALL DESCRIPTION In this Program Project, we will investigate the role of trained immunity in transplantation and allograft rejection. Our preliminary clinical and preclinical data reveal a direct and causal link between allotransplantation, the induction of trained immunity, a systemic inflammatory response, and the aggravation of T cell-mediated alloimmunity. The successful completion of this application will lend support to (i) the concept that trained immunity plays an essential role in organ transplantation and graft rejection and (ii) yield effective preclinical nanotherapies and imaging approaches to treat and study graft rejection, and (iii) new hypothesis, setting the stage for future studies, including those aimed at clinically translating our findings and technologies.

PI_NAMEs: FAYAD, ZAHI A. (contact);MADSEN, JOREN C

PROGRAM_OFFICER_NAME: KULKARNI, SHILPA S

PROJECT_TERMS: allograft rejection;Allografting;allotransplant;Amplifiers;Animals;antimicrobial;authority;Autoimmune Diseases;Automobile Driving;B-Lymphocytes;Bioinformatics;Biology;Biomedical Engineering;Biopsy;Bone Marrow;Bone Marrow Diseases;cancer risk;Cells;Cellular Assay;Chronic;Clinical;Clinical Data;Clinical Research;clinically relevant;computerized data processing;Data;design;Diagnosis;Epigenetic Process;fluorodeoxyglucose positron emission tomography;Future;Graft Rejection;heart allograft;Heart Transplantation;Hematopoietic;Hematopoietic stem cells;Human;Image;image translation;imaging approach;imaging modality;Immune;immune activation;Immune Tolerance;Immunity;Immunologic Memory;Immunology;ImmunoPET;Immunosuppression;in vivo;Infection;Inflammation;Inflammatory;Inflammatory Response;innovation;insight;isoimmunity;Kidney;Kidney Transplantation;Link;Mediating;Metabolic;Metabolism;Modeling;Modernization;Modification;Monitor;monocyte;multidisciplinary;multiple omics;Mus;Myeloid Cells;Myelopoiesis;nanobiologic;Nanotechnology;nanotherapeutic;nanotherapy;Natural Immunity;non-invasive imaging;nonhuman primate;novel;novel therapeutic intervention;Organ failure;organ transplant rejection;Patients;Peripheral Blood Mononuclear Cell;Play;Positron-Emission Tomography;pre-clinical;Pre-Clinical Model;preclinical study;Predisposition;prevent;progenitor;programs;Publishing;Regimen;Research Personnel;response;Role;Scientist;side effect;success;synergism;System;systemic inflammatory response;T-Cell Activation;T-Lymphocyte;Technology;Testing;Therapeutic;Therapeutic immunosuppression;therapeutic target;Time;tool;Toxic effect;Training;Translating;Transplant Recipients;Transplant-Related Disorder;Transplantation;Validation;Visualization;Work

PROJECT_TITLE: Targeting trained immunity in transplantation


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Pediatric;Prevention;Social Determinants of Health

PI_NAMEs: PINHEIRO, LAURA C (contact)

PROJECT_TERMS: Address;Area;behavioral and social science;Biometry;Cancer Burden;Cancer Control;Cancer Family;cancer health disparity;cancer prevention;cancer risk;career;Caring;clinical epidemiology;Communities;Consolidated Framework for Implementation Research;Consultations;Data;Data Analyses;Data Collection;Data Commons;Data Element;data harmonization;Data Science;data standards;design;Development;Disease Management;Doctor of Philosophy;Education;Educational Curriculum;Educational process of instructing;eighth grade;Enrollment;Ensure;Environmental Science;Epidemiology;Evaluation;Faculty;Federally Qualified Health Center;Feedback;Fostering;Goals;Health;health disparity;health equity;health inequalities;Health Sciences;Health Services Research;Healthcare Systems;Hospitals;implementation framework;implementation science;Individual;Inequity;Infrastructure;innovation;Intervention;junior high school;Malignant Neoplasms;Mathematics;Measures;Medical center;meetings;Methodology;Methods;Mission;Monitor;Needs Assessment;New York;New York City;novel;patient navigation;Patient Outcomes Assessments;patient portal;Patients;Pilot Projects;poor communities;Poverty;Poverty Areas;Presbyterian Church;Prevention;Productivity;programs;quitline;randomized trial;Research;Research Design;Research Methodology;Research Personnel;Research Project Grants;Resources;Risk Reduction;satisfaction;Schools;Science;science teacher;Scientist;screening;social capital;social epidemiology;social health determinants;Standardization;structural health determinants;Surveys;synergism;System;Teenagers;Testing;Tobacco;tobacco cessation intervention;Training;Universities;Work

PROJECT_TITLE: RESEARCH METHODS CORE


NIH_SPENDING_CATS: Transplantation

PI_NAMEs: FAYAD, ZAHI A. (contact)

PROJECT_TERMS: Acceleration;Accountability;Adherence;Authorization documentation;Award;Biostatistics Core;Boston;Collaborations;Communities;data management;design;empowerment;Engineering;Ensure;Environment;experience;Faculty;Feedback;Funding;Goals;Human Resources;imaging science;Immunity;Immunology;Institution;Knowledge;Laboratories;Lead;Leadership;meetings;member;nanomedicine;Nanotechnology;National Heart, Lung, and Blood Institute;New York City;Principal Investigator;programs;Radiology Specialty;Research;Research Personnel;Research Project Grants;Resources;Self-Examination;Series;skills;Solid;Students;support network;teacher;Training;translational goal;Transplantation;Work

PROJECT_TITLE: Administrative, data management and biostatistics core


PROJECT_TERMS: Biology;Biomedical Engineering;biomedical imaging;Bone Marrow;CD8-Positive T-Lymphocytes;CD8B1 gene;Cells;Chemistry;Deposition;Development;Dose;Drug Kinetics;Ensure;Epigenetic Process;experience;experimental study;fluorodeoxyglucose;fluorophore;Glycolysis;Goals;Human Resources;Image;imaging agent;imaging probe;imaging study;Immune;Immunity;ImmunoPET;Immunotherapeutic agent;in vivo;Intervention;ITGAM gene;Libraries;Liver;Mass Spectrum Analysis;Metabolic;Metabolism;Modeling;Monitor;Mus;Myeloid Cells;nanobiologic;nanobodies;nanolabel;nanomaterials;nanomedicine;nanotherapeutic;nanotherapy;novel;nuclear imaging;pharmacodynamic model;pharmacokinetics and pharmacodynamics;Positron-Emission Tomography;Process;programs;Radioactive;Radiochemistry;Radioisotopes;Regimen;Research;Sampling;Spleen;success;Therapeutic;Therapeutic Studies;therapeutic target;Tissues;Training;Transplantation

PROJECT_TITLE: Bioengineering core


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Genetics;Human Genome;Pediatric

ORG_CITY: AUSTIN

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

ORG_STATE: TX

PHR: Craniofacial birth defects are extremely common due to the complexity of craniofacial development. We will characterize how multifactorial interactions between genetics and the environment disrupt the cell signaling interactions that drive the integration of the distinct cell types with the vertebrate head. The results we obtain will translate directly to human disease, providing candidate loci for association studies, risk factors for genetic counseling and potential therapies.

PI_NAMEs: EBERHART, JOHANN K (contact)

PROGRAM_OFFICER_NAME: SAIFUDEEN, ZUBAIDA

PROJECT_TERMS: career;cell type;Congenital Abnormality;craniofacial;craniofacial complex;craniofacial development;craniofacial tissue;Defect;Development;Diagnosis;Dysmorphology;Educational workshop;Eligibility Determination;Ensure;Environment;Fellowship;gene environment interaction;Genetic;Genetic Counseling;genetic risk factor;Grant Review;Head;Human;human disease;International;Mediating;meetings;Mentors;Morphogenesis;Muscle;notch protein;Process;Productivity;programs;Publications;Recruitment Activity;Research;Scientist;Services;Severities;Signal Transduction;STEM field;Tendon structure;Training;Translating;undergraduate student;United States National Institutes of Health;Work;Zebrafish

PROJECT_TITLE: Mechanisms underlying the multifaceted basis of craniofacial dysmorphogenesis


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

PI_NAMEs: PHILLIPS, ERICA  (contact)

PROJECT_TERMS: active control group;Address;Adherence;Adolescent;Adult;Age;Behavior;behavior change;Behavioral;Beverages;Black race;built environment;Cancer Burden;Cancer Control Research;cancer education;cancer health disparity;cancer initiation;cancer prevention;cancer risk;Caregivers;Characteristics;Child;Cities;Collaborations;Communication;Country;Data;design;Disparity;Education;Educational Curriculum;Educational Intervention;Educational process of instructing;effectiveness testing;empowerment;ethnic minority;Ethnic Origin;experience;Exposure to;Failure;Family;Family member;Fellowship;follow-up;Future;Goals;Health;Health Promotion;Hispanic;Home;Household;improved;Incidence;Individual;innovation;Intention;Intervention;Intervention Studies;Interview;junior high school;Knowledge;lens;Life Cycle Stages;Life Style;Low income;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Marketing;Mathematics;Modeling;Neighborhoods;New York City;Nonprofit Organizations;Outcome Measure;Parents;Personal Satisfaction;Population Study;post intervention;Poverty;Poverty Areas;Preparation;Prevention program;primary outcome;programs;racial minority;Randomized;Research;residence;Resources;response;Rest;Risk Behaviors;Risk Factors;rural counties;Schools;science teacher;secondary outcome;Self Determination;social capital;Social Change;social consciousness;social culture;Social Justice;Specific qualifier value;Stress;Students;System;teacher;Testing;theories;therapy design;Training;Training Programs;Unemployment;United States;Vulnerable Populations;Waiting Lists;young adult;Youth

PROJECT_TITLE: PROJECT 1


NIH_SPENDING_CATS: Aging;Biotechnology;Cancer;Colorectal Cancer;Digestive Diseases;Genetics;Prevention;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: BALTIMORE

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: We have derived a novel in-vitro colon organoids model to explore the hypothesis that age-dependent risk for initiation of colorectal cancers (CRC) depends upon abnormal DNA methylation and associated gene silencing. We have determined that gene silencing is functional for driving the aging-like changes and accelerating one- step transformation of older cells to cancer notably by BRAF mutations. A key ultra-translational possibility addressed in this proposal is that reversing these methylation changes and gene silencing might significantly diminish CRC risk and enhance biomarker approaches.

PI_NAMEs: BAYLIN, STEPHEN B. (contact);EASWARAN, HARIHARAN

PROGRAM_OFFICER_NAME: OKANO, PAUL

PROJECT_TERMS: Acceleration;Address;Affect;Age;age acceleration;age group;age related;age related changes;aged;Aging;aging related;Animal Testing;APC mutation;Automobile Driving;Azacitidine;Biological Assay;Biological Markers;BRAF gene;cancer initiation;cancer predisposition;cancer risk;cancer subtypes;cell transformation;Cells;Characteristics;Chronic;Clustered Regularly Interspaced Short Palindromic Repeats;Colon;Colon Carcinoma;Colonic Polyps;Colorectal Cancer;colorectal cancer prevention;colorectal cancer progression;colorectal cancer risk;complement pathway;CpG Islands;CRISPR/Cas technology;Data;demethylation;Dependence;Development;disorder risk;Distal;DNA;DNA Methylation;driver mutation;Engineering;Epigenetic Process;epigenetic therapy;Evolution;Feedback;Frequencies;Gene Expression;Gene Silencing;Genes;Germ Lines;Germ-Line Mutation;Growth;high risk;Histologic;Human;Hypermethylation;In Vitro;in vivo;independency;Individual;Inflammatory;Inflammatory Bowel Diseases;insight;Intercept;Intestines;KRAS oncogenesis;KRAS2 gene;Left;Malignant Neoplasms;Mediating;Methylation;Modeling;Monitor;mouse model;Mucinous;Mus;mutant;Mutation;normal aging;novel;novel strategies;old mice;Oncogenic;Organoids;Pathway interactions;Patients;Pattern;pharmacologic;Phenotype;polyposis;Population;pre-clinical;Predisposition;prevent;Prevention;Process;promoter;Repression;Risk;Risk Factors;Risk Reduction;Role;Side;Standardization;stem;stem cells;stemness;Syndrome;System;Testing;Time;tumor;tumor progression;Tumor Promotion;tumorigenesis;WNT Signaling Pathway;Work

PROJECT_TITLE: Organoid modeling to determine and reverse age-related epigenetic changes contributing to risk of colorectal cancer

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 1 Study Section[MCT1]


NIH_SPENDING_CATS: Networking and Information Technology R&D (NITRD);Organ Transplantation;Transplantation

PI_NAMEs: OCHANDO, JORDI  (contact)

PROJECT_TERMS: Address;Animals;Bioinformatics;Biological Assay;Biometry;Cells;Cellular Assay;Clinical;Communication;Computer software;Custom;Data;Data Analyses;data exploration;data handling;data integration;data management;data pipeline;Data Set;Data Storage and Retrieval;Ensure;Epigenetic Process;epigenome;Equipment and supply inventories;experience;Experimental Designs;experimental study;Flow Cytometry;Gene Expression;Genes;Head;Human;human error;Image;Immune;Immunity;Immunologist;in silico;In Vitro;in vivo;Infrastructure;International;Investigation;Laboratories;Laboratory Research;large datasets;medical schools;Medicine;Metabolic Pathway;Metabolism;monocyte;multiple data types;multiple omics;Mus;Netherlands;next generation sequencing;Organ Transplant Research;Procedures;professor;programs;Protocols documentation;Records;Reproducibility;Research Personnel;Sampling;Standardization;success;System;Testing;Therapeutic;therapeutic target;Training;transcription factor;transcriptomics;Transplantation

PROJECT_TITLE: Mechanistic and Bioinformatics Core


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurosciences;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE In this secondary data analysis proposal, we will address critical and timely questions about effects of social inequality on the brain and on substance use. We leverage existing datasets from the Adolescent Brain Cognitive Development (ABCD) study and the Minnesota Center for Twin and Family Research (MCTFR) to identify neurobehavioral deviations linking childhood socioeconomic disadvantage and substance use trajectories in adolescence and adulthood. Identifying individuals and families at the greatest risk for problematic substance use trajectories informs development of the most targeted prevention and intervention efforts possible for substance misuse and use disorder.

PI_NAMEs: WILSON, SYLIA  (contact)

PROGRAM_OFFICER_NAME: PRABHAKAR, JANANI

PROJECT_TERMS: addiction;Address;Adolescence;Adolescent;Adult;Affect;Alcohols;Attenuated;Brain;brain circuitry;Cannabis;Child;Childhood;cognitive control;cognitive development;cohort;Communities;cost effective;COVID-19;COVID-19 pandemic;Data Analyses;Data Set;deprivation;Development;disadvantaged background;Disadvantaged minority;Discrimination;Disease;Distal;early childhood;Economic Factors;economic indicator;Economics;Education;Emotional;ethnic minority;Ethnic Origin;Etiology;experience;Exposure to;Family;Family Research;Financial Hardship;Functional Magnetic Resonance Imaging;Genetic;genome wide association study;Growth;Health;Household;Income;indexing;Individual;Inequality;Informal Social Control;Intervention;Life;Link;Longitudinal cohort study;marginalization;Measurable;Measures;Mediating;Mediation;Minnesota;minority children;Modeling;multimodality;neurobehavioral;Neurocognitive;Nicotine;Occupations;Outcome;Participant;Perception;Performance;polygenic risk score;Population;Poverty;preadolescence;Prevention;Preventive;Process;prospective;protective effect;Public Health;Race;racial minority;Research;Research Design;Resources;reward processing;Rewards;Risk;Risk Factors;Sampling;social;social disparities;social factors;Social status;socioeconomic disadvantage;Socioeconomic Status;socioeconomics;stressor;Structure;substance misuse;substance use;Substance Use Disorder;Testing;Time;Twin Multiple Birth;United States

PROJECT_TITLE: Neurobehavioral mechanisms linking childhood social disadvantage with substance use trajectories in adolescence and adulthood


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: SAN FRANCISCO

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE The UCSF Department of Surgery's T32 training grant titled “Filling a Void of Research Training for Transplant Surgeons” (FAVOR) will provide two years of funding for in-depth training in translational immunology for 2 surgery residents/year with an interest in transplant surgery, to prepare them for careers as academic transplant surgeons. The goal of the FAVOR T32 is to train and inspire a unique cadre of surgeon-scientists to translate astute observations at the bedside, in the operating room, and in the clinic into novel hypotheses that can be interrogated through immunology-focused translational research.

PI_NAMEs: SARWAL, MINNIE M;STOCK, PETER G (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Research Training;Transplant Surgeon

PROJECT_TITLE: Filling a Void of Research (FAVOR) Training for Transplant Surgeons

STUDY_SECTION: AITC

STUDY_SECTION_NAME: Allergy, Immunology, and Transplantation Research Committee[AITC]


NIH_SPENDING_CATS: Clinical Research;Kidney Disease;Organ Transplantation;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

PI_NAMEs: MULDER, WILLEM  (contact)

PROJECT_TERMS: Academic Medical Centers;Acute;adaptive immune response;Adaptive Immune System;adaptive immunity;Affect;Allografting;Antigens;antimicrobial;ATAC-seq;Automobile Driving;B-Lymphocytes;Behavior;biobank;Biological Markers;Bone Marrow;Bone Marrow Aspiration;Cells;Clinical;Collaborations;Complex;cytokine;Data;design;diagnostic tool;Epigenetic Process;epigenetic profiling;experience;fluorodeoxyglucose positron emission tomography;follow-up;Foundations;Gene Expression Profiling;Graft Rejection;Graft Survival;heart allograft;Heart Transplantation;Hematopoietic stem cells;Human;Immune;Immune response;Immunity;Immunologic Memory;Immunologic Tests;Immunologist;Immunotherapeutic agent;In Vitro;Incubated;Infiltration;Inflammation;Inflammatory;Innate Immune Response;insight;Kidney Transplantation;Lead;Leukocytes;longitudinal, prospective study;Macrophage;Mediating;member;Modification;Molecular;monocyte;mouse model;multidisciplinary;multiple omics;Myeloid Progenitor Cells;nano;nanobiologic;Natural Immunity;Natural Killer Cells;non-invasive imaging;nonhuman primate;novel;novel diagnostics;novel therapeutics;organ transplant rejection;Organ Transplantation;Outcome;Pathway interactions;Patient Care;Patients;Pattern;Play;post-transplant;pre-clinical;prevent;Production;progenitor;programs;Regulatory T-Lymphocyte;Reperfusion Injury;Research Personnel;response;Role;Sampling;Serum;T-Lymphocyte;Testing;Therapeutic;Therapeutic immunosuppression;Training;transcriptome sequencing;Transplant Recipients;Transplantation;Transplantation Immunology;Work

PROJECT_TITLE: Elucidating the role of trained immunity in kidney transplant patients


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Lung Cancer;Patient Safety;Prevention;Primary Health Care;Social Determinants of Health;Substance Misuse;Tobacco;Tobacco Smoke and Health

PI_NAMEs: MATTHEWS, ALICIA K (contact)

PROJECT_TERMS: active control group;Address;Adult;arm;Awareness;Behavioral;Cancer Control;Caring;Centers for Disease Control and Prevention (U.S.);Cessation of life;Clinical;Clinical Trials Design;compare effectiveness;cost;Counseling;Education;Educational Materials;effectiveness evaluation;Electronic Health Record;Enrollment;Family health status;Federally Qualified Health Center;Future;Goals;Health;health care delivery;health disparity;health inequalities;health information technology;Healthcare;Height;implementation evaluation;implementation strategy;improved;Individual;Infrastructure;innovation;Intake;Link;Low income;Low Income Population;Malignant Neoplasms;Measures;Methods;Mission;modifiable risk;Neighborhoods;New York;nicotine patch;novel strategies;outreach;Participant;Patient Education;patient navigation;patient oriented;patient portal;Patients;Pattern;Persons;Pharmacotherapy;Population;population based;Population Intervention;Poverty;Poverty Areas;primary outcome;Professional counselor;Provider;public health priorities;quitline;Randomized;randomized trial;randomized, clinical trials;Recommendation;reduce tobacco use;Reporting;Risk Factors;safety net;screening;Screening for cancer;Self Determination;Smoke;Smoker;Smoking;smoking cessation;Smoking Cessation Intervention;smoking prevalence;social;social capital;telephone coaching;theories;Tobacco;Tobacco use;Tobacco Use Cessation;Uninsured;Vulnerable Populations

PROJECT_TITLE: PROJECT 2


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

ORG_CITY: WASHINGTON

ORG_NAME: INTERNATIONAL BROTHERHOOD OF TEAMSTERS

ORG_STATE: DC

PHR: Principal Investigator/Program Director (Last, First, Middle): Byrd, Lamont FOA Number RFA-ES-19-003 Project Narrative (Overall) The IBT Consortium represents and has ready access to tens of thousands of workers throughout the U.S. who remediate hazardous waste sites, transport hazardous wastes, handle, package, transport and warehouse hazardous materials, and respond to hazardous materials releases. The IBT Consortium is staffed by a team of experienced worker health and safety training experts who specialize in industrial hygiene, curriculum development, adult education techniques, information technology, and craft-experienced worker-trainers. The combination of access to worker populations and institutional capacities enables the IBT Consortium to deliver high quality model training that complies with the NIEHS Minimum Criteria, applicable standards and regulations as promulgated by the Environmental Protection Agency (EPA), Occupational Safety and Health Administration (OSHA), and the Department of Homeland Security (DHS). IBT Consortium Page 1 Project Narrative (Overall)

PI_NAMEs: AUSTIN, CHARLES  (contact)

PROGRAM_OFFICER_NAME: BEARD, SHARON

PROJECT_TERMS: Accidents;Address;Adult;Affect;Air;Alabama;Area;California;career;Career Choice;Chicago;Communities;Competence;Connecticut;curriculum development;Disasters;Educational Technics;Electronic Mail;Emergency response;Employment;experience;first responder;Florida;Funding;Grant;Hazardous Substances;Hazardous Waste;Hazardous Waste Sites;Health;high risk;Idaho;Illinois;Indiana;Industrial Health;Industry;Information Technology;institutional capacity;International;Life;Los Angeles;Louisiana;Maine;Maryland;Massachusetts;member;Mississippi;Missouri;Modeling;Names;National Institute of Environmental Health Sciences;Natural Disasters;neighborhood disadvantage;Nevada;New Hampshire;New Jersey;New Mexico;New York;North Carolina;Occupations;Ohio;Oregon;Participant;Pennsylvania;Population;Principal Investigator;programs;Puerto Rico;Readiness;Recovery;recruit;Recycling;Regulation;remediation;resilience;response;Rhode Island;Safety;Security;Site;skills;Solid;South Carolina;Target Populations;Telephone;Tennessee;Texas;Training;Training Programs;Transportation;U-Series Cooperative Agreements;underserved community;Underserved Population;United States Environmental Protection Agency;United States Occupational Safety and Health Administration;Utah;Vermont;Virginia;Washington;wasting;web site;Work

PROJECT_TITLE: International Brotherhood of Teamsters Hazardous Materials Worker Health and Safety Training


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Cardiovascular;Clinical Research;Digestive Diseases;Hematology;Inflammatory Bowel Disease

ORG_CITY: SALT LAKE CITY

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE Platelets have emerged as effector cells capable of mediating inflammation either directly or through interactions with other immune cells or the vasculature. Platelet dysfunction correlates with disease severity in many inflammatory disorders including cardiovascular disease, sepsis, atherosclerosis, and inflammatory bowel disease. The research proposed is highly relevant to public health as the mechanisms through which platelets regulate inflammation and inflammation-associated thrombosis are not well understood and therefore necessitate further study to develop improved therapies to enhance human life and wellness.

PI_NAMEs: PETREY, AARON CHRISTOPHER (contact)

PROGRAM_OFFICER_NAME: WARREN, RONALD Q

PROJECT_TERMS: Abnormal Platelet;Address;Adhesions;Adhesives;Affect;Agonist;Alpha Granule;American;Atherosclerosis;Autopsy;Biological Assay;Biological Response Modifiers;Biology;Blood;Blood coagulation;Blood Platelets;Blood Vessels;burden of illness;C Type Lectin Receptors;C-Type Lectins;Cardiovascular Diseases;Cause of Death;CD44 Antigens;Cell Adhesion;Cell surface;Cells;Clinical;Colitis;Complex;CRISPR/Cas technology;Crohn's disease;Data;Development;Disease;disease model;Disease Outcome;Effector Cell;Event;Fatal Outcome;Functional disorder;Gastrointestinal tract structure;Gene Expression;Gene Expression Profiling;General Population;Genetic;Genetic Transcription;Glycosaminoglycans;Guanosine Triphosphate;gut inflammation;Hemostatic function;Homeostasis;Human;human disease;Hyaluronan;Immune;Immune response;Immunology;improved;In Vitro;in vivo;Incidence;Individual;Inflammation;Inflammatory;Inflammatory Bowel Diseases;inflammatory marker;Inflammatory Response;inhibitor;innovation;Integrins;Intestinal Diseases;intravital microscopy;Leukocytes;Life;Ligands;Link;Mediating;Metabolism;Molecular;Monomeric GTP-Binding Proteins;mortality;mouse model;Mucous Membrane;murine colitis;Mus;novel;novel strategies;novel therapeutics;Outcome;Pathogenesis;Pathway interactions;Patients;pharmacologic;Platelet Activation;Play;Predisposition;preservation;Public Health;receptor;Reporting;Research;Resources;response;Risk;Role;scaffold;Sepsis;Severities;Severity of illness;Signal Transduction;Steroids;Stream;Structure;Surface;Techniques;Testing;therapeutic target;Thromboembolism;thromboinflammation;Thrombophilia;Thrombosis;thrombotic;Tissues;transcriptome sequencing;Travel;Treatment Protocols;Ulcerative Colitis;Vascular Endothelial Cell;venous thromboembolism;Venous Thrombosis;Work

PROJECT_TITLE: The Role of Layilin as a Novel Regulator of Platelet Activation and Thromboinflammation

STUDY_SECTION: HTBT

STUDY_SECTION_NAME: Hemostasis, Thrombosis, Blood Cells and Transfusion Study Section[HTBT]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cannabinoid Research;Clinical Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

ORG_CITY: BATON ROUGE

ORG_DEPT: PSYCHOLOGY

ORG_NAME: LOUISIANA STATE UNIV A&M COL BATON ROUGE

ORG_STATE: LA

PHR: Project Narrative Cannabis misuse among Black individuals in the United States poses a major public health concern. The proposed research uses ecological momentary assessment to strive to better understand antecedents of cannabis use motivation and cannabis use and related problems among this population by examining racial/ethnic microaggressions (MAs) – brief, subtle, yet common forms of everyday discrimination due to racial/ethnic status – that may prompt Black individuals to be more motivated to use cannabis to mitigate MA- related negative affect and engage in risky patterns of cannabis use. Through this research, we also will explore mediational processes and moderators in the link between MA and cannabis use and related problems that will inform future intervention and prevention efforts for this neglected health disparities group.

PI_NAMEs: BUCKNER, JULIA D (contact)

PROGRAM_OFFICER_NAME: DUNSTON, SHEBA KING

PROJECT_TERMS: Accounting;Address;Adult;Affect;Anger;Anxiety;anxiety sensitivity;Attention;Behavioral;Biological;Black American;Black Populations;Black race;Cannabis;cannabis craving;cannabis use behavior;Carcinogens;Caring;Communities;coping;craving;Data;Discrimination;Distress;drinking;Drug Addiction;Drug usage;Ecological momentary assessment;emotional symptom;Ethnic Origin;experience;Exposure to;Female;Frequencies;Future;Goals;hate crimes;health disparity;health disparity populations;health equity;health inequalities;Hispanic;improved;Individual;insight;Intention;Intervention;intervention program;Investigation;Knowledge;Life;life span;Link;marginalized population;marijuana use;marijuana use disorder;Mental Depression;Mental Health;Methodology;Methods;microaggression;minority health;minority stress;Modeling;Motivation;National Institute of Drug Abuse;Nature;negative affect;neglect;Outcome;Participant;perceived discrimination;Persons;Population;Prevention;Prevention program;Process;promote resilience;prospective;Public Health;Publishing;Race;racial discrimination;racial identity;racial minority population;Religiosity;Research;Research Project Grants;resilience;resilience factor;response;Risk;Risk Assessment;Risk Factors;Role;Sampling;social;Source;Strategic Planning;stressor;substance use;Testing;time use;Toxin;United States;United States National Institutes of Health;verbal;Work

PROJECT_TITLE: Ecological Momentary Assessment of Racial/Ethnic Microaggressions and Cannabis Use among Black Adults

STUDY_SECTION: ARM

STUDY_SECTION_NAME: Addiction Risks and Mechanisms Study Section[ARM]


NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Heart Disease;Kidney Disease;Nanotechnology;Organ Transplantation;Transplantation

PI_NAMEs: TEUNISSEN, ABRAHAM  (contact)

PROJECT_TERMS: Acute;allograft rejection;Allograft Tolerance;Allografting;allotransplant;Animal Experiments;Animals;Automobile Driving;biomaterial compatibility;Bone Marrow;C57BL/6 Mouse;Cells;Chronic;clinically relevant;Data;design;Dose;Epigenetic Process;epigenome;experimental study;Family suidae;FRAP1 gene;Genetic;Goals;Graft Rejection;Graft Survival;Heart;heart allograft;Heart Transplantation;Hematopoietic stem cells;Human;Image;Immune;immune activation;Immune response;Immune system;Immune Tolerance;Immunity;Immunologic Memory;Immunologics;ImmunoPET;Immunosuppression;in vivo;inhibitor;innovation;insight;isoimmunity;Kidney;kidney allograft;Kidney Transplantation;Knock-out;Knockout Mice;Libraries;liver allograft;Longitudinal Studies;lung allograft;Mediating;Metabolic;Metabolism;Modeling;Modification;Monitor;Morbidity - disease rate;mouse model;multiple omics;Mus;Myeloid Cells;nanobiologic;nanotherapeutic;nanotherapy;new therapeutic target;nonhuman primate;Organ;Organ failure;Organ Transplantation;Pathway interactions;Patients;Play;Positron-Emission Tomography;post-transplant;Predisposition;preservation;Production;Rattus;Reperfusion Injury;Research Personnel;Resistance;Role;side effect;stem;Stimulus;success;System;Testing;Therapeutic;Therapeutic immunosuppression;Training;transcriptome;transplant model;Transplantation;Treatment Efficacy

PROJECT_TITLE: Studying and regulating trained immunity in mouse transplant models


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Social Determinants of Health

PI_NAMEs: CARRASCO, YAZMIN PAULINA (contact)

PROJECT_TERMS: Acceleration;anti-cancer research;Area;Cancer Center;Cancer Control;cancer health disparity;cancer prevention;cancer risk;career;Clinical;Clinical and Translational Science Awards;Clinical Research;college;Communities;community collaboration;Comprehensive Cancer Center;Dedications;Development;Ecology;Education;Eligibility Determination;expectation;Faculty;faculty support;Federally Qualified Health Center;Fellowship;Fostering;Foundations;Funding;Goals;Grant;Health;Health Disparities Research;health equity;Health Sciences;Health system;Height;Herbert Irving Comprehensive Cancer Center;high school;Incidence;Individual;Infrastructure;Institution;Jasminum;Justice;Malignant Neoplasms;Medical center;meetings;member;Mentors;Methods;Mission;mortality;Movement;New York;Online Systems;personalized approach;poor communities;Population;Positioning Attribute;Postbaccalaureate;Postdoctoral Fellow;Poverty;Poverty Areas;programs;Research;Research Methodology;Research Personnel;Resources;Risk Reduction;Schools;Secure;skills;social capital;Social Network;Students;synergism;Training;Training and Education;Training Programs;undergraduate student;underserved community;Universities;Washington;Work

PROJECT_TITLE: Career E Core


ADMINISTERING_IC: NS

ED_INST_TYPE: OVERALL MEDICAL

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Genetics;Neurosciences

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE Astrocytes are highly elaborate cells that are key regulators of brain development, function, and maintenance, and astrocyte dysfunction results in devastating neurological conditions. We propose to dissect a novel, evolutionarily conserved pathway that is required for normal astrocyte growth and brain function. Our work will define fundamental cellular mechanisms that control astrocyte development, their contributions to brain health and function, and should provide critical insights into our understanding of astrocyte dysfunction in human disease.

PI_NAMEs: FREEMAN, MARC R;MONK, KELLY R (contact)

PROGRAM_OFFICER_NAME: TYLER, WILLIAM A

PROJECT_TERMS: Alexander Disease;Animal Behavior;Astrocytes;autism spectrum disorder;Axon;Biological Assay;Blood Vessels;Brain;brain cell;brain health;cell growth;cell motility;Cell Physiology;cell type;Cells;Cellular biology;Central Nervous System;comparison control;Data;Defect;Development;Drosophila genus;Endoderm;Environment;Enzymes;Epilepsy;Exhibits;extracellular;fly;Foundations;Functional disorder;G-Protein-Coupled Receptors;gene conservation;Genes;Genetic;genetic approach;Genetic Models;Genetic Screening;Germ Cells;Goals;Growth;Homeostasis;Homologous Gene;Human;human disease;Image;in vivo;in vivo imaging;Individual;Infiltration;insight;ionic balance;knock-down;Light;lipid phosphate phosphatase;Lipids;live cell imaging;Maintenance;Membrane;Molecular;Molecular Genetics;Morphogenesis;Morphology;Mus;mutant;Mutation;nervous system development;Nervous System Disorder;neural circuit;Neuroglia;Neurologic;neuronal cell body;Neurons;Neuropil;Neurotransmitters;novel;Nutrient;Organism;Orthologous Gene;Pathway interactions;Phenocopy;Physiology;Process;Protein phosphatase;Regulation;RNA Interference;RNA interference screen;Role;Signal Pathway;Signal Transduction;Signaling Molecule;Specific qualifier value;Synapses;synaptogenesis;tool;Vertebrates;Visualization;wasting;Work;Zebrafish

PROJECT_TITLE: Molecular pathways regulating astrocyte morphogenesis and function

STUDY_SECTION: NDPR

STUDY_SECTION_NAME: Neurodifferentiation, Plasticity, Regeneration and Rhythmicity Study Section[NDPR-M]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Human Genome;Neurosciences;Substance Misuse

ORG_CITY: CORAL GABLES

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE Alcohol addiction is a debilitating disorder characterized by long-term changes in brain function that underlie pathological drinking behaviors. Diagnostic criteria for alcohol addiction consistently identify continued alcohol drinking behaviors at the expense of healthy alternative rewards, and continued use despite adverse consequences (“compulsivity”) as key features. We demonstrate that epigenetic enzymes, known to mediate long-term changes in brain function, are associated with individual vulnerability to developing compulsivity. The goal of the proposed studies is to determine the mechanisms by which these epigenetic enzymes reprogram the brain for alcohol disorder, knowledge that may ultimately lead to novel therapeutic strategies.

PI_NAMEs: WAHLESTEDT, CLAES ROBERT (contact)

PROGRAM_OFFICER_NAME: LORANG-LEINS, DOMINIQUE

PROJECT_TERMS: Accounting;activity marker;addiction;adverse outcome;Alcohol consumption;Alcohol dependence;alcohol effect;alcohol seeking behavior;alcohol use disorder;Alcohols;Amygdaloid structure;Anatomy;anti-cancer;Anxiety;Attenuated;Autopsy;Behavior;Behavioral;Brain;Brain region;brain tissue;burden of illness;Cell Nucleus;cell type;Cells;Chemicals;Chromatin;Cleavage Under Targets and Release Using Nuclease;Clinical;clinically relevant;clinically significant;Communities;Complex;compulsion;Compulsive Behavior;Data;Designer Drugs;designer receptors exclusively activated by designer drugs;Detection;diagnostic criteria;Disease;DNA;drinking behavior;druggable target;Enhancers;Ensure;Enterobacteria phage P1 Cre recombinase;Environmental Risk Factor;Enzymes;Epigenetic Process;epigenetic profiling;experimental study;EZH2 gene;GABA transporter;gamma-Aminobutyric Acid;Gene Expression Profile;gene network;Genes;Genetic;genetic risk factor;Genetic Transcription;Goals;Health;Heritability;Histone H3;histone methylation;Histones;Human;Individual;inducible Cre;Infusion procedures;inhibitor;knock-down;Knowledge;Laboratory Animals;Link;Locomotion;Lysine;Mediating;Mental disorders;Methylation;Methyltransferase;Minority;Minority Groups;Modeling;Modification;Molecular;motivated behavior;Motivation;neural circuit;neuroadaptation;Neurobiology;Neuroglia;Neurons;novel;novel therapeutic intervention;Nuclear;Nuclear RNA;overexpression;Pain;Pathologic;Persons;pharmacologic;Polycomb;Population;programs;promoter;protein activation;Protein Inhibition;protein kinase C-delta;Proteins;Public Health;Punishment;Rat Transgene;Rattus;Reading;receptor;Regulation;Research;Resistance;response;Rewards;RNA;Rodent;Role;Self Administration;Signal Transduction;Specificity;Stimulus;Stress;Systematic Bias;Techniques;Technology;Testing;Therapeutic;therapeutic target;Tissue-Specific Gene Expression;Training;Transcriptional Regulation;transcriptional reprogramming;transcriptome;transcriptome sequencing;transcriptomics;Virus;Vulnerable Populations;Work

PROJECT_TITLE: Epigenetic modulation of amygdalar circuits that control alcohol compulsivity

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: CAMACHO, MARLENE  (contact)

PROJECT_TERMS: Address;anti-cancer research;Area;Bioinformatics;Biomedical Research;breast cancer family registry;Cancer health equity;career;career development;Clinical;Clinical Research;Clinical Sciences;cohort;Cohort Analysis;Cohort Studies;Collaborations;Communities;community advisory board;community engaged intervention;community engagement;Data;Data Analyses;data harmonization;data sharing;Development;early-career faculty;Eligibility Determination;Endowment;Equity;experience;Extramural Activities;Faculty;Feedback;Funding;Funding Opportunities;Future;Grant;Health;health equity;health inequalities;Health Sciences;innovation;Institution;interest;Malignant Neoplasms;Medical center;member;Mentors;Methodology;Minority-Serving Institution;Mission;Modeling;National Heart, Lung, and Blood Institute;National Institute on Minority Health and Health Disparities;New York City;Outcome;Participant;patient engagement;Pilot Projects;Positioning Attribute;Poverty;Poverty Areas;Process;Production;programs;Research;Research Activity;research facility;Research Infrastructure;Research Methodology;Research Personnel;Research Project Grants;Resources;Scientist;social capital;Study Section;synergism;Training;Training Programs;translational oncology;Underrepresented Populations;United States National Institutes of Health;Universities;web site;Writing

PROJECT_TITLE: Developmental Core


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Genetics;Neurosciences;Nutrition;Prevention;Substance Misuse

ORG_CITY: WINSTON-SALEM

ORG_DEPT: NEUROSCIENCES

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

ORG_STATE: NC

PHR: Project Narrative Appropriate regulation of chromatin structure and gene expression is critical for normal synaptic plasticity, and this regulation is markedly disrupted in pathological substance use disorders. Our laboratory has found that metabolites that act as key cofactors for chromatin modifying enzymes are markedly altered by drugs of abuse. These studies will identify mechanistically how metabolites and their interactions with chromatin modifying enzymes affect brain and behavior and will provide strategies for targeting the metabolome to reduce pathological drug use.

PI_NAMEs: KIRALY, DREW  (contact)

PROGRAM_OFFICER_NAME: LOSSIE, AMY C

PROJECT_TERMS: Affect;ATAC-seq;Behavior;Behavioral;behavioral response;Binding Sites;Brain;cell growth regulation;Cells;Chromatin;Chromatin Structure;cofactor;Coupled;Data;dietary restriction;Dietary Supplementation;DNA;Drug Controls;drug of abuse;Drug usage;Drug Utilization;Environment;Enzymes;Epigenetic Process;epigenetic regulation;Exposure to;Gene Expression;Genes;genetic manipulation;histone modification;Histones;Intake;Laboratories;Literature;Mass Spectrum Analysis;Metabolic;Metabolism;Metabolite Interaction;metabolome;metabolomics;motivated behavior;novel;Nucleus Accumbens;Pathologic;Pattern;Pharmaceutical Preparations;Point Mutation;prevent;protein complex;Regulation;Relapse;Role;Self Administration;Serum;Signal Transduction;Specificity;Substance Use Disorder;Synaptic plasticity;Targeted Research;Technology;Transgenic Mice;Translational Research;Withdrawal

PROJECT_TITLE: Targeting the host metabolome to reverse drug-induced epigenetic changes


NIH_SPENDING_CATS: Aging;Breastfeeding, Lactation and Breast Milk;Cardiovascular;Estrogen;Genetics;Hypertension;Kidney Disease;Menopause;Nutrition;Women's Health Research

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Kidney electrolyte handling in females vs males over life cycle Dysregulation of fluid and electrolyte transport in the kidney is central to hypertension and cardiovascular disease progression, which are leading contributors to premature death around the globe. Na+, K+, and volume homeostasis are mediated by regulation of ion and water transporters expressed in renal tubule specific patterns; K+ balance also depends on regulation of muscle transporters. By combining experimental and computational approaches in rodents, this MPI project aims to fill important gaps in knowledge about how male and female nephrons and muscles adjust operation over life cycle to maintain electrolyte homeostasis and blood pressure in response to the challenges of development, lactation, menopause, aging, and dietary salts, knowledge that can guide the appropriate choice of therapeutic targets in both sexes across life cycle.

PI_NAMEs: EDWARDS, AURELIE ;MCDONOUGH, ALICIA A. (contact)

PROGRAM_OFFICER_NAME: KETCHUM, CHRISTIAN J

PROJECT_TERMS: 4-vinylcyclohexene diepoxide;absorption;Adult;Age;Aging;Anatomy;Angiotensin II;Automobile Driving;Blood Pressure;blood pressure elevation;Cardiovascular Diseases;Cause of Death;Cells;Cessation of life;Chromosomes;Complex;complex data;Computer Models;cost;Data Collection;Data Set;Dependence;Development;Diet;dietary;dietary salt;dimorphism;Disease Progression;Distal;Electrolytes;Equilibrium;Exhibits;Female;Fluid Balance;Four Core Genotypes;Funding;Genetic Models;Goals;Gonadal Hormones;high salt diet;Homeostasis;Human;Hypertension;Intervention;Ions;Kidney;Knowledge;Lactation;Life Cycle Stages;Life Style;Liquid substance;male;Mediating;Membrane Transport Proteins;Menopause;Modeling;Modification;mouse genetics;mouse model;Mus;Muscle;Natriuresis;Nature;Nephrons;operation;Outcome;Output;Partner in relationship;Pattern;Physiological;Physiology;Plasma;Ploidies;Postmenopause;Pregnancy;premature;prepuberty;pressure;Process;Pump;Rattus;Regulation;Renal function;Renal tubule structure;Reporting;Reproduction;response;Rodent;Role;Saline;salt sensitive hypertension;saluretic;sex;Sex Chromosomes;Sex Differences;sexual dimorphism;Site;Skeletal Muscle;Sodium Chloride;Sprague-Dawley Rats;Testing;therapeutic target;Tubular formation;Validation;water channel;women versus men

PROJECT_TITLE: Renal electrolyte handling in females vs. males over life cycle

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-W(05)]


NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Heart Disease;Immunotherapy;Kidney Disease;Nanotechnology;Organ Transplantation;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

PI_NAMEs: MADSEN, JOREN C (contact)

PROJECT_TERMS: adaptive immune response;adaptive immunity;Affect;Allograft Tolerance;Allografting;Anti-Inflammatory Agents;Autoimmune Diseases;Automobile Driving;B-Lymphocytes;Biological Assay;Bone Marrow;Bone Marrow Diseases;Bone Marrow Transplantation;Cells;Chimerism;Chronic;Collaborations;comparison control;conditioning;design;Epigenetic Process;Exhibits;Funding;Graft Survival;Graft Tolerance;Heart;heart allograft;Hematopoietic;Hematopoietic stem cells;Human;Immune;Immune Tolerance;Immunity;Immunologic Memory;Immunologics;Immunosuppression;Immunotherapy;Inflammation;Inflammatory;Inflammatory Response Pathway;innovation;insight;Kidney;kidney allograft;Kidney Transplantation;Laboratories;lipophilicity;Lipoproteins;Liver;Lung;Macaca fascicularis;Macrophage;Metabolic;Modeling;Modification;Molecular;Monkeys;Morbidity - disease rate;mortality;mTOR inhibition;mTOR Inhibitor;Mus;Myeloid Cells;nanobiologic;Nanoimmunotherapy;nanomaterials;nanotherapeutic;nanotherapy;Nature;nonhuman primate;novel;Organ;Organ Transplantation;pathogen;Play;post-transplant;prevent;Prodrugs;Protocols documentation;Reporting;Resistance;response;Role;Sirolimus;T cell response;T-Lymphocyte;Testing;Therapeutic;Time;Training;Transplant-Related Disorder;Transplantation

PROJECT_TITLE: Using trained immunity-inhibiting nanobiologics to achieve tolerance of heart allografts in non-human primates


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Cancer;Colorectal Cancer;Digestive Diseases;Orphan Drug;Rare Diseases

ORG_CITY: BUFFALO

ORG_NAME: THERAPYX, INC.

PHR: NARRATIVE-PUBLIC HEALTH RELEVANCE Familial Adenomatous Polyposis (FAP) is an incurable autosomal dominant genetic disease afflicting some 50,000 Americans. Hundreds to thousands of adenomas develop in the rectum and colon, forcing colectomy usually in the second decade of life, to avoid colorectal cancer. This Phase IIb proposal seeks to further the development of an oral formulation of the key regulatory cytokine interleukin-10 (IL-10NanoCap®) as a novel therapy for FAP than can safely, sustainable and conveniently deliver this potent immune signal directly to the gut.

PI_NAMEs: AUCI, DOMINICK  (contact);EGILMEZ, NEJAT K

PROGRAM_OFFICER_NAME: LUNSFORD, DWAYNE

PROJECT_TERMS: adenoma;American;ApcMin/+ mice;Attenuated;autosome;Award;Bacteroides fragilis;Biological;Biological Sciences;Clinical;clinical development;Clinical Protocols;Clinical Trials;clinically relevant;Colectomy;Collaborations;Colon;Colon Carcinoma;Colorectal Cancer;commercialization readiness;comparative;cytokine;design;Development;Development Plans;Dominant Genetic Conditions;Dose;drug development;Drug Kinetics;Familial Adenomatous Polyposis Syndrome;Food, Drug and Cosmetic Act;Formulation;Funding;Future;Genetic Diseases;Grant;Homeostasis;human model;Immune;Immune signaling;Industry Standard;Interleukin-10;Intestinal Polyposis;Investigational Drugs;Life;Light;Long-Term Effects;Macaca fascicularis;manufacture;manufacturing process;manufacturing scale-up;meetings;Methods;Monkeys;mouse model;New Drug Approvals;nonhuman primate;novel therapeutics;Oral;Oral Administration;Orphan;Orphan Drugs;Particulate;Patients;Pharmaceutical Preparations;Pharmacologic Substance;Phase;pre-clinical;pre-Investigational New Drug meeting;preclinical development;Preparation;Process;product development;Production;Program Development;programs;public health relevance;Publishing;Rare Diseases;Readiness;Recommendation;Recovery;Rectum;response;Safety;scale up;Serum;Small Business Innovation Research Grant;Specific qualifier value;Structure;success;Suggestion;Therapeutic;Therapeutic Equivalency;Toxic effect;Toxicology;treatment optimization;Treatment Protocols;tumor progression;tumorigenesis;United States National Institutes of Health;Validation;Work

PROJECT_TITLE: IL-10NanoCap® for Therapy of Familial Adenomatous Polyposis


NIH_SPENDING_CATS: Prevention

PROJECT_TERMS: Academy;Accidents;Address;Air;California;Chemicals;Communities;community organizations;Competence;Connecticut;Electronic Mail;Emergency response;Employment;Environment;Excision;experience;Exposure to;falls;Fire - disasters;Florida;Funding;Grant;hazard;Hazardous Substances;Hazardous Waste;Hazardous Waste Sites;Health;Height;Hour;Idaho;Illinois;Indiana;Industry;Infrastructure;Institution;International;Lifting;Louisiana;Maine;Massachusetts;Missouri;Names;Natural Disasters;neighborhood safety;Nevada;New Hampshire;New Jersey;New Mexico;North Carolina;Occupational;occupational hazard;Occupations;Ohio;Oregon;Positioning Attribute;Principal Investigator;programs;recruit;Recycling;remediation;resilience;Rhode Island;Safety;Security;Site;Solid;South Carolina;Target Populations;Telephone;Tennessee;Texas;Training;Training Programs;Transportation;Utah;Vermont;Washington;wasting;web site;Work;worker safety;Workplace

PROJECT_TITLE: International Brotherhood of Teamsters Hazardous Waste Worker Training Program Application


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Genetics;Neurosciences;Rare Diseases

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: PROJECT NARRATIVE The solid tumor microenvironment includes nerve fibers arising from the peripheral nervous system. The formation of new nerve fibers within and around solid tumors plays an active role in cancer development, progression and resistance to treatment. This proposal will explore the exact mechanisms that drive nerves to infiltrate tumors and support their growth and progression.

PI_NAMEs: AMIT, MORAN  (contact)

PROGRAM_OFFICER_NAME: JHAPPAN, CHAMELLI

PROJECT_TERMS: Ablation;Address;Adrenergic Agents;afferent nerve;Afferent Neurons;angiogenesis;Attention;Axon;axonal sprouting;Biological Models;Biometry;Blood Vessels;Breast;Cancer Biology;cancer cell;cancer genetics;cancer therapy;cancer type;candidate identification;Cell Communication;cell type;Cells;Cellular biology;Cellular Structures;Clinical;Complement;Complex;Cues;Data;Development;Epithelium;Event;exosome;Genes;genetic approach;Genetic Engineering;Genetic Transcription;Genetically Engineered Mouse;Goals;Growth;Head and Neck Cancer;Human;improved;Infiltration;Inflammation;innovation;insight;Knowledge;Light;malignant mouth neoplasm;Malignant Neoplasms;Mediating;Mediator;MicroRNAs;Molecular;mouse model;mouth squamous cell carcinoma;Neoplasms;neoplastic cell;Nerve;Nerve Fibers;nerve supply;neural;Neurobiology;neurodevelopment;Neuroepithelial, Perineurial, and Schwann Cell Neoplasm;Neurogenic Inflammation;neuronal tumor;Neurons;neurotransmission;new therapeutic target;novel strategies;novel therapeutic intervention;Oncology;Oral;oral cavity epithelium;Outcome;Pancreas;Pathologic;Pathology;Patients;perineural;Peripheral Nervous System;Persons;pharmacologic;Phenotype;Play;Positioning Attribute;pre-clinical;Pre-Clinical Model;prevent;Process;programs;Prostate;Quality of life;recruit;release factor;Research;Resistance;response;RNA;Role;Shapes;Signal Induction;Signal Repression;Signal Transduction;Small RNA;Solid Neoplasm;Stomach;success;Supporting Cell;targeted cancer therapy;Testing;Therapeutic;therapy development;therapy resistant;Time;TP53 gene;Transcriptional Activation;treatment response;tumor;tumor behavior;Tumor Biology;Tumor Cell Invasion;tumor growth;tumor microenvironment;tumor progression;Tumor Promotion;Tumor-Derived;tumorigenesis;Work

PROJECT_TITLE: Defining the Role of Tumor-Neural Crosstalk in head and Neck Cancer Progression and Treatment Resistance

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OBT-H(55)R]


NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Prevention

PROJECT_TERMS: Academy;Accidents;Address;Affect;Alabama;Area;California;Chemicals;Communities;community organizations;Competence;Connecticut;Disasters;Electronic Mail;Emergency response;Employment;Environment;Excision;experience;Exposure to;falls;Fire - disasters;Florida;Funding;Grant;Hand;hazard;hazardous materials disaster;Hazardous Substances;Health;Height;high risk;Hour;Human Resources;Infrastructure;Institution;International;Lifting;Louisiana;Maine;Maryland;Massachusetts;member;Mississippi;Names;Natural Disasters;neighborhood safety;New Hampshire;New Jersey;New York;North Carolina;Occupational;occupational hazard;Occupations;operation;Pennsylvania;Positioning Attribute;Principal Investigator;programs;Puerto Rico;Readiness;recruit;resilience;response;Safety;Security;Shipping;skills training;South Carolina;Target Populations;Telephone;Texas;Training;Training Programs;Transportation;Virginia;Washington;web site;Work;worker safety;Workplace

PROJECT_TITLE: International Brotherhood of Teamsters Hazmat Disaster Preparedness Training Program


ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

PHR: Narrative – Miami Center for AIDS Research The Miami Center for AIDS Research (CFAR) at the University of Miami Miller School of Medicine is applying for funding for 5 more years, representing a 4th renewal cycle. It is the only CFAR in Florida, a state with the highest rate of new infections in the U.S., and Miami is the epicenter of the HIV/AIDS epidemic, underscoring the need for a CFAR. The mission of the Miami CFAR is to advance HIV/AIDS research by providing scientific leadership and developing an infrastructure that fosters integration of basic, clinical, and behavioral/social sciences, promotes education and mentorship, and partners with the community and Florida Department of Health to prevent, treat and cure HIV/AIDS, ultimately to end the HIV epidemic.

PI_NAMEs: PAHWA, SAVITA  (contact)

PROGRAM_OFFICER_NAME: REFSLAND, ERIC WILLIAM

PROJECT_TERMS: Academy;Achievement;Acquired Immunodeficiency Syndrome;acronyms;Administrative Supplement;Advisory Committees;Affect;African American population;Aging;AIDS related cancer;Area;Award;base;behavioral and social science;biobehavior;Cancer Center;career development;Career Mobility;Child;Clinical;Clinical Sciences;Cohort Studies;Collaborations;Communicable Diseases;Communities;community advisory board;community engagement;Community Outreach;County;Dedications;Development;Doctor of Philosophy;Education;Elements;Emerging Communicable Diseases;Epidemic;Event;experience;Faculty;Faculty Recruitment;Federally Qualified Health Center;Florida;Fostering;Funding;Geography;Goals;Grant;Growth;Health;Health equity research;HIV;HIV diagnosis;HIV/AIDS;Hospitals;Immune response;Immunotherapy;improved;Individual;Industry;Infection;Inflammation;Infrastructure;Injecting drug user;innovation;Institution;Interest Group;International;Knowledge;Laboratories;Latino;Latinx;Leadership;Lesbian Gay Bisexual Transgender Queer;Life;Link;Malignant Neoplasms;medical schools;men who have sex with men;Mental Health;Mentors;Mentorship;Metabolism;Minority;Mission;National Institute of Mental Health;Needle-Exchange Programs;Needs Assessment;Neurosciences;next generation;novel;perinatal HIV;Persons;Play;Policies;Positioning Attribute;pre-exposure prophylaxis;prevent;programs;recruit;reproductive outcome;Research;Research Personnel;Resource Allocation;Resources;Role;Science;Shapes;Strategic Planning;success;synergism;The Multicenter AIDS Cohort Study;tool;Translational Research;transmission process;Treatment outcome;United States National Institutes of Health;Universities;Woman;Women's Interagency HIV Study;working group

PROJECT_TITLE: Miami Center for AIDS Research


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Autoimmune Disease;Diabetes;Digestive Diseases;Liver Disease;Regenerative Medicine

ORG_DEPT: NUTRITION

PHR: NARRATIVE Our recent works with drugs which oppose glucagon action demonstrate effective lowering of blood glucose in animal models of type 1 diabetes with an unexpected and profound increase in insulin-producing beta cells. As such, suppressing glucagon production or action on target tissues (which include the liver and the beta cell) may be a viable target area for the treatment and prevention of Type 1 diabetes. Here we evaluate the ability of glucagon blockade to improve beta cell regeneration, the source of new beta cells, and the tissue-to-tissue communication which triggers the regeneration of beta cells in mouse models of T1D and human islets.

PI_NAMEs: HOLLAND, WILLIAM L (contact)

PROGRAM_OFFICER_NAME: HWA, ALBERT J

PROJECT_TERMS: Ablation;Aftercare;Alpha Cell;amino acid metabolism;Amino Acids;Animal Model;antagonist;Apoptosis;Apoptotic;Area;B-Lymphocytes;Beta Cell;Blood Glucose;blood glucose regulation;Carbohydrates;cell regeneration;Cell Survival;Cells;CHES1 gene;cofactor;Communication;Data;diabetic;Diabetic mouse;Dissection;Ductal Epithelial Cell;euglycemia;Fasting;Fatty acid glycerol esters;Fc Receptor;FGF2 gene;Fibroblast Growth Factor Receptor 2;Fibroblast Growth Factor Receptors;Functional Regeneration;functional restoration;Genetic;Genetic Transcription;Glucagon;Glucagon Receptor;Gluconeogenesis;Glucose;glucose production;Hepatic;Hormones;Human;Hyperplasia;Impairment;improved;in vivo;in vivo regeneration;Inbred NOD Mice;incretin hormone;Insulin;insulin secretion;Insulin-Dependent Diabetes Mellitus;islet;Islets of Langerhans;Link;Liver;Mediating;Mediator;Metabolic Diseases;Modeling;Monoclonal Antibodies;mouse model;Mus;Natural regeneration;non-diabetic;Non-Insulin-Dependent Diabetes Mellitus;novel;overexpression;pancreatic juice;Persons;Pharmaceutical Preparations;Phosphorylation;Plasma;precursor cell;prevent;Prevention;Production;promoter;Proteins;Publishing;Recombinant Fibroblast Growth Factor;regenerative;Repression;Rodent;Role;Signal Transduction;Skeletal Muscle;Source;Tetracyclines;Tissues;Transcription Repressor;Transgenic Mice;Up-Regulation;uptake;Work

PROJECT_TITLE: Liver-islet and intra-islet cross talk in alpha cell hyperplasia and beta cell regeneration


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Dental, Oral, and Craniofacial Disease;Drug Abuse (NIDA only);Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Prevention;Substance Misuse

PROJECT_TERMS: Academia;Accounting;Acquired Immunodeficiency Syndrome;Administrator;Adopted;Advisory Committees;Basic Science;Behavioral Sciences;Budgets;Clinical Research;Clinical Sciences;Collaborations;Committee Members;Communication;Communities;community engagement;Community Services;Complement;Country;County;Development;Doctor of Philosophy;Education;Educational Activities;Emerging Communicable Diseases;Environment;Epidemic;Event;Faculty Recruitment;Feedback;Florida;Fostering;Funding;graduate student;Grant;Grant Review;Guidelines;Health;HIV;HIV diagnosis;HIV Infections;HIV/AIDS;Immunology;Individual;Infrastructure;Interest Group;Leadership;Link;meetings;member;Mentors;Mentorship;Microbiology;Mission;operation;Outcome Measure;pedagogy;Policies;Positioning Attribute;Postdoctoral Fellow;prevent;Procedures;Productivity;programs;Recommendation;recruit;Reporting;Research;Research Activity;Research Personnel;Research Priority;Research Support;Resources;response;Schools;Secure;Series;Strategic Planning;symposium;synergism;United States National Institutes of Health;Universities;Update;Visit;Work;working group

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Clinical Research;Dental, Oral, and Craniofacial Disease;Drug Abuse (NIDA only);Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Prevention;Substance Misuse

PI_NAMEs: SCOTT, GWENDOLYN BARBARA (contact)

PROJECT_TERMS: Academy;Acquired Immunodeficiency Syndrome;acronyms;Address;Advisory Committees;Aging;Animal Care and Use Committees;antiretroviral therapy;Award;Basic Science;Behavioral;behavioral and social science;Behavioral Research;biobehavior;California;Cancer Center;career;career development;Clinical;Clinical Research;Clinical Sciences;Clinical Services;Collaborations;Communities;community engagement;community partners;Core Grant;County;COVID-19;Credentialing;Data;Development;Development Plans;Doctor of Philosophy;Education;Educational process of instructing;Educational workshop;electronic data;Emerging Communicable Diseases;Epidemic;Exercise;experience;Extramural Activities;Faculty;Feedback;Florida;Fostering;Funding;Funding Mechanisms;Funding Opportunities;Future;Goals;Grant;Health;health disparity;high risk population;HIV;HIV/AIDS;IACUC;Immunology;Individual;Infrastructure;innovation;Inosine Diphosphate;Institution;institutional biosafety committee;Institutional Review Boards;Interest Group;International;Investments;Laboratories;Leadership;medical schools;medical specialties;meetings;member;men who have sex with men;Mental Health;Mentors;Mentorship;minority investigator;Mission;National Cancer Institute;next generation;Peer Review;Philosophy;Policies;Positioning Attribute;Postdoctoral Fellow;posters;practical application;pre-exposure prophylaxis;prevent;programs;Publications;recruit;Research;Research Activity;research and development;Research Personnel;Research Support;Resources;Review Committee;Role;San Francisco;Science;Structure;symposium;tool;Training Programs;Translational Research;Travel;Underrepresented Populations;United States National Institutes of Health;Universities;Vaccines;working group;Writing


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Infectious Diseases;Vector-Borne Diseases

ORG_CITY: STATESBORO

ORG_DEPT: BIOLOGY

ORG_NAME: GEORGIA SOUTHERN UNIVERSITY

PHR: PROJECT NARATIVE It has been hypothesized that insect immune responses can be harnessed to control the spread of vector-borne diseases. Although fleas transmit numerous deadly and debilitating diseases to humans, relatively little is known about how they defend themselves from infection under natural conditions. The proposed research aims to address basic entomological questions related to flea ecological immunology, which could aid in the development of novel control strategies for flea-borne diseases.

PI_NAMEs: BROWN, LISA DIANE (contact)

PROGRAM_OFFICER_NAME: COSTERO-SAINT DENIS, ADRIANA

PROJECT_TERMS: Address;Adult;Affect;Age;Antibacterial Response;Bacterial Infections;bacterial vector;base;Biological Products;Bubonic Plague;California;Cat-Scratch Disease;Chemical Agents;Communities;companion animal;compare effectiveness;Data;Defense Mechanisms;density;Development;Diet;Disease;disease transmission;Disease Vectors;disorder control;Domestic Animals;Drug usage;Ecology;Effectiveness;Endemic Flea-Borne Typhus;Environmental Impact;environmental stressor;experience;Exposure to;Felis catus;fighting;flea-borne;Fleas;Food;Genes;Genetic;Genus Felis;Goals;gut microbiota;Habitats;Human;Immune;Immune response;Immune system;immune system function;Immunity;Immunologics;Immunology;immunoregulation;Individual;Infection;infection risk;Innate Immune System;Insect Vectors;Insecta;Insecticides;insight;Intrinsic factor;Invaded;Knowledge;Larva;Lead;Light;Measures;Methods;microbial;Modification;Molecular;non-genetic;novel;novel strategies;Organism;Outcome;pathogen;pathogenic bacteria;Pharmacotherapy;Physiological;Play;Population;Predisposition;Prevalence;prevent;programs;Public Health;Recording of previous events;Research;Resources;Rodent;Role;sex;Site;spotted fever;Stress;Testing;Texas;trait;Transcriptional Regulation;transmission process;United States;vector;vector control;vector-borne pathogen;Vector-transmitted infectious disease

PROJECT_TITLE: Ecological immunology of a flea vector (Ctenocephalides felis)


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Dental, Oral, and Craniofacial Disease;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Prevention;Substance Misuse;Women's Health Research

PI_NAMEs: ALCAIDE, MARIA LUISA (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Adolescent;Aging;AIDS prevention;Area;Behavioral;Behavioral Research;Biological;Biometry;Child;cis-female;Clinic;Clinical;Clinical assessments;Clinical Management;Clinical Research;Clinical Sciences;cohort;Collaborations;Communities;Data;Data Collection;Data Management Resources;Databases;Development;Drug user;electronic data;Enrollment;Epidemic;Ethics;Exercise;experience;Florida;Fostering;Funding;Geographic Locations;Grant;HIV;HIV vaccine;HIV/AIDS;Hospitals;human data;Human Resources;human subject;Human Subject Research;implementation trial;improved;Infrastructure;innovation;Institution;Interdisciplinary Study;Investigation;Laboratories;Leadership;Life Cycle Stages;Link;Manuscripts;Medical center;Methodology;multidisciplinary;Personal Satisfaction;Persons;Pilot Projects;Play;Population;Populations at Risk;pre-exposure prophylaxis;Pregnancy;Prevention;Prevention trial;Process;programs;Publications;Qualifying;Research;Research Design;research facility;Research Methodology;Research Personnel;Research Priority;research study;Resources;response;Rights;Role;sample collection;Scientist;Services;social;Social Behavior;sound;Specimen;Statistical Data Interpretation;Strategic Planning;success;System;tool;Training;Training and Education;transgender women;Translational Research;translational study;Underrepresented Populations;United States National Institutes of Health;Universities;vaccine access;welfare;Woman;Women's Group

PROJECT_TITLE: Clinical Sciences Core


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Biotechnology;Cancer;Cancer Genomics;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Dental, Oral, and Craniofacial Disease;Drug Abuse (NIDA only);Emerging Infectious Diseases;Genetics;HIV/AIDS;Human Genome;Infectious Diseases;Pediatric;Prevention;Substance Misuse;Women's Health Research

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;acronyms;Address;Administrative Supplement;Adolescence;Advisory Committees;Affect;Applications Grants;Area;assay development;base;Benchmarking;biobank;biobehavior;Biological Assay;Cancer Center;cancer genomics;Cells;cervicovaginal;Child;Childhood;Clinical;Clinical Sciences;Cohort Studies;Collaborations;collaboratory;Communicable Diseases;Consultations;COVID-19;COVID-19 pandemic;COVID-19 Prevention Network;Data;data portal;Data Science;Dedications;Development;Dryness;Educational workshop;Emerging Communicable Diseases;Ensure;Epidemic;Equipment;Exercise;expectation;Faculty;Florida;Funding;Generations;Genomics;Goals;HIV;HIV Vaccine Trials Network;HIV/AIDS;Immunology;improved;Individual;innovation;Institution;interest;Interest Group;International;International Maternal Pediatric Adolescent AIDS Clinical Trials;Laboratories;Lavage;lectures;Letters;Life;meetings;Mentorship;Microbiology;microbiome;Needs Assessment;new technology;novel;perinatal HIV;Periodicals;Policies;Procedures;programs;Publications;quality assurance;Research;Research Activity;Research Design;Research Institute;Research Personnel;Research Priority;Research Project Grants;Research Support;Resource Sharing;Resources;Science;Scientific Advances and Accomplishments;Services;Sexual Health;Students;success;symposium;synergism;Techniques;Technology;Training;Translational Research;undergraduate student;United States National Institutes of Health;Universities;Update;virology;Virus;Woman;working group

PROJECT_TITLE: Laboratory Sciences Core