ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Depression;Machine Learning and Artificial Intelligence;Major Depressive Disorder;Mental Health;Neurosciences

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative Affective mood disorders, such as major depressive disorder (MDD), are challenging to treat and have a disproportionate impact on society and health care costs. A key challenge in developing effective treatments for MDD is that it is more commonly diagnosed in women that in men and coping strategies are typically different. The aim of this proposal is to incorporate social decision making and motivation in a sex-dependent manner to understand the spectrum of social stress coping mechanisms and identify the brain-wide neural signature of social resiliency.

PI_NAMEs: NAVARRETE, JOVANA  (contact)

PROGRAM_OFFICER_NAME: PINARD, COURTNEY ROSE

PROJECT_TERMS: Acute;Affective;Anatomy;Automobile Driving;awake;Awareness;Behavior;Behavioral;Brain;Brain region;Calcium;cell type;Chronic;Classification;Clinical;comorbidity;Complex;computational neuroscience;computer framework;Consult;coping;coping mechanism;Coping Skills;Data;Decision Making;Depressed mood;Development;Dopamine Receptor;effective therapy;Emotions;Exhibits;Experimental Designs;Exposure to;Female;Fiber;Future;genetic approach;Goals;Health Care Costs;Health Professional;Image;Immunohistochemistry;Individual;Individual Differences;Injections;insight;Institution;interest;Investigation;Light;Literature;machine learning pipeline;machine learning prediction;Major Depressive Disorder;male;Maps;men;Microscopy;Modeling;Modernization;Mood Disorders;Motivation;Mus;neural;neural network;neuromechanism;Neurons;neuropsychiatry;Neurosciences;novel;Nucleus Accumbens;optogenetics;Phenotype;Photometry;Population;Population Heterogeneity;pre-clinical;Predisposition;Procedures;Recombinant adeno-associated virus (rAAV);Reproducibility;Research;resilience;resilient behavior;response;reward circuitry;Rewards;Rhodopsin;Role;Running;Sensory;sex;sex as a biological variable;social;Social Behavior;social contact;social defeat;social deficits;social metrics;social stress;Societies;Stains;Stress;stress resilience;Techniques;temporal measurement;Time;Tracer;Training;Transgenic Mice;Viral;wireless;women's diagnosis;Work

PROJECT_TITLE: Cell-type and whole-brain dynamics underlying operant social stress resiliency


ADMINISTERING_IC: EY

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Eye Disease and Disorders of Vision;Neurosciences

ORG_COUNTRY: UNITED STATES

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_FIPS: US

PHR: Project Narrative Humans rely on vision and perceptual decision-making for healthy functioning and survival. Impairments in visual processing and perceptual decision-making are significant causes of morbidity in neurological and psychiatric disorders, including Alzheimer’s disease and schizophrenia, but the brain regions and computations that give rise to visual decision formation remain poorly understood. The goal of this proposal is to gain mentored training and leverage modern electrophysiological, computational, and behavioral approaches to map visual, motor, and abstract decision coding in the midbrain reticular nucleus, a potentially novel node in the distributed network underlying visual perceptual decision-making.

PI_NAMEs: SHAKER, JORDAN ROBERT (contact)

PROGRAM_OFFICER_NAME: CLAYTON, EDWIN C

PROJECT_TERMS: Address;Alzheimer's Disease;Area;arm movement;Basal Ganglia;Behavior;Behavioral;Brain;Brain region;career;Cell Nucleus;clinical training;Code;Cognition;Cognitive;cognitive function;Complex;Computer Analysis;Corpus striatum structure;Cues;Decision Making;design;Disease;Electrophysiology (science);Environment;Goals;high dimensionality;Histologic;Human;Image;Impairment;improved;Institution;Learning;Locomotion;Maps;Medical;Mental disorders;Mentors;Methods;Midbrain structure;Modeling;Modernization;Morbidity - disease rate;Motor;Motor Cortex;Motor output;Movement;Mus;Nervous System Disorder;neural;Neurons;neuropsychiatric disorder;neurotransmission;novel;Pathway interactions;Perception;Physicians;Play;Population;Process;Production;Prosencephalon;Recurrence;Reporting;response;Rodent;Role;Saccades;Scheme;Schizophrenia;Scientist;Sensory;Signal Transduction;skills;Stimulus;Structure;superior colliculus Corpora quadrigemina;Task Performances;Techniques;Training;Vision;Visual;Visual attention;visual learning;visual map;visual plasticity;visual processing;visual stimulus;Work

PROJECT_TITLE: The Role of the Midbrain Reticular Nucleus in Vision and Perceptual Decision-Making


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: BALTIMORE

ORG_DEPT: CHEMISTRY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Narrative The principles of chemistry describe the molecular interactions that define life and distinguish between sickness and health. Consequently, a chemical approach to biomedical research reveals the fundamental basis for proper cellular function and the potential for misfunction. The Chemistry Biology Interface Program trains the next generation of scientists to apply the knowledge of chemistry to questions of biological and medical significance.

PI_NAMEs: ROKITA, STEVEN E (contact)

PROGRAM_OFFICER_NAME: HARTON, MARIE DEBORAHGAYNELLE

PROJECT_TERMS: Biology;Chemistry;programs;Universities

PROJECT_TITLE: The Chemistry-Biology Interface Program at Johns Hopkins University

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - B[TWD-B]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: TAMPA

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF SOUTH FLORIDA

ORG_STATE: FL

PHR: Project Narrative Alzheimer’s disease is a devastating neurodegenerative disease affecting ~6.5 million Americans aged 65 and older with no currently available treatment that reverses the course of the disease. BIN1 is the second most significant locus according to genome-wide associate studies for the development of late onset Alzheimer’s disease, only behind ApoE4, and we have very little idea of how BIN1 may confer increased risk for Alzheimer’s disease. I will use a novel discovery approach coupled to the latest advancements in quantitative mass spectrometry to define the BIN1 protein interaction network, which will lead to the discovery of new BIN1 functional pathways that may increase Alzheimer’s disease risk.

PI_NAMEs: MCMILLAN, JOSEPH  (contact)

PROGRAM_OFFICER_NAME: SARE, RACHEL

PROJECT_TERMS: Address;Adult;Affect;Age;age related neurodegeneration;Alternative Splicing;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease risk;American;Amyloidosis;anti-cancer research;apolipoprotein E-4;Bioinformatics;Biological Process;Biotin;Biotinylation;Brain;Brain Diseases;brain tissue;Cellular biology;Clathrin;Cluster Analysis;Complement;Core Facility;Coupled;Data Analyses;detection method;Development;Disease;Dynamin;Endocytosis;Environment;Enzymes;Experimental Designs;experimental study;Functional disorder;Future;Genes;Genetic;genetic risk factor;genome wide association study;Gliosis;grasp;gray matter;Health;Human;human old age (65+);Immunofluorescence Immunologic;Immunoprecipitation;In Vitro;in vivo;innovation;Interdisciplinary Study;interest;Investigation;Kinetics;Knowledge;Label;Laboratories;Late Onset Alzheimer Disease;Learning;lifestyle factors;Ligase;Link;Mass Spectrum Analysis;Mediating;Mentors;Methods;molecular pathology;mouse model;Mus;Muscle Development;Nature;Neighborhoods;Neuroblastoma;neuroblastoma cell;Neurodegenerative Disorders;neuron loss;Neurons;novel;Older Population;Pathogenesis;Pathogenicity;Pathology;Pathway interactions;pre-doctoral;promoter;Protein Isoforms;protein protein interaction;protein purification;Proteins;Proteome;Proteomics;Radial;Recycling;Research;Research Training;Retrieval;Risk;Risk Factors;Severities;Skeletal Muscle;superresolution microscopy;Synapses;Synapsins;Synaptic Vesicles;SYNJ1 gene;System;tau Proteins;Therapeutic;tool;Translating;Translations;Tumor Suppressor Proteins;vesicular release;Wild Type Mouse;Work

PROJECT_TITLE: BIN1-interactome in Alzheimer's disease pathophysiology


FUNDING_MECHANISM: NON-SBIR/STTR RPGS

ORG_CITY: WICHITA

ORG_NAME: WICHITA STATE UNIVERSITY

ORG_STATE: KS

PI_NAMEs: JONAS, KIM CAROL (contact)

PROJECT_TERMS: Adaptor Signaling Protein;Address;age related;age related changes;aged;Aging;Assisted Reproductive Technology;Binding;Binding Proteins;Biological Markers;Cell Line;Cell membrane;Cells;Color;Complex;Confocal Microscopy;Coupled;Cyclic AMP;Data;Development;dimer;Dissociation;encryption;Endocytosis;Endosomes;Exhibits;Fc Receptor;Follicle Stimulating Hormone;Follicle Stimulating Hormone Receptor;folliculogenesis;Funding;G-Protein-Coupled Receptors;Generations;Glycoproteins;glycosylation;Goals;granulosa cell;Hormone Receptor;Hormones;improved;in vivo;insight;Kinetics;Knock-in Mouse;Link;Luciferases;Mediating;Microscopy;Modification;monomer;Mus;N-terminal;Nature;novel;Occupations;Outcome;Output;Ovarian;Ovarian aging;Ovarian Granulosa Cell;overexpression;Pathway interactions;Pattern;Peptides;Personal Satisfaction;Pituitary Gland;Population;Production;Proteins;Proto-Oncogene Proteins c-akt;Publishing;receptor;receptor expression;receptor function;receptor internalization;Receptor Signaling;Receptor-Interacting Protein;recruit;Regulation;Reporter Genes;Reporting;reproductive;Role;sensor;Serum;Signal Pathway;Signal Transduction;Small Interfering RNA;stoichiometry;Testing;Therapeutic;Total Internal Reflection Fluorescent;trafficking;Woman;Women's Health

PROJECT_TITLE: Project 3: Understanding the Role of FSHR Oligomerization and Trafficking in Transducing Age-dependent Changes in FSH Glycoforms


ORG_CITY: Nashville

ORG_DEPT: BIOLOGY

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: Project Narrative The goals and training philosophy of the proposed MARC at Vanderbilt T34 Institutional Training Program are congruent with and contribute to the overarching mission of the MARC mechanism - to develop a diverse pool of undergraduates who complete their baccalaureate degree, and transition into and complete biomedical, research-focused higher degree programs (e.g., Ph.D. or M.D./Ph.D.). Our training program is designed to ensure that future biomedical faculty and researchers are drawn from the entire diverse undergraduate talent pool at Vanderbilt to expand and enable a more inclusive and productive biomedical research community. The relevance of this training for public health cannot be understated, as it is the education and research training of young scientists that will provide the foundation for future discovery.

PI_NAMEs: FRIEDMAN, KATHERINE LOUISE;MCMAHON, DOUGLAS G (contact)

PROGRAM_OFFICER_NAME: STOKES, KALYNDA K

PROJECT_TERMS: Achievement;Astronomy;Biological Sciences;Biomedical Engineering;Biomedical Research;biomedical scientist;career development;CCL7 gene;Chemistry;college;computer science;Dedications;diversity and inclusion;Educational Curriculum;Eligibility Determination;Environment;Faculty;Foundations;Future;Goals;graduate school;Heart;Immersion;Institution;Laboratories;mathematical ability;Mentors;Mission;Neurosciences;next generation;Physics;programs;Psychology;Qualifying;Records;recruit;Request for Proposals;Research;Research Personnel;Research Support;Scholarship;Schools;Science;skills;STEM field;Structure;Students;success;Teacher Professional Development;Training;Training Programs;undergraduate research;undergraduate student;Underrepresented Populations;Underrepresented Students;United States National Institutes of Health;Universities

PROJECT_TITLE: MARC at Vanderbilt University

STUDY_SECTION_NAME: Training and Workforce Development Study Section - D[TWD-D]


NIH_SPENDING_CATS: Aging;Clinical Research;Contraception/Reproduction;Estrogen;Women's Health Research

PI_NAMEs: BOUSFIELD, GEORGE R (contact)

PROJECT_TERMS: access restrictions;Adaptor Signaling Protein;Affect;Affinity;Age;age related changes;Aging;Antibodies;Binding;Binding Sites;Biological;Biological Assay;Blood;bone loss;bone mass;Carbohydrates;Cell membrane;Collaborations;college;Complex;Cryoelectron Microscopy;Cultured Cells;Data;differential expression;drug development;Enzyme-Linked Immunosorbent Assay;Estrogens;Exhibits;extracellular;Family;Family Planning;Feedback;Fertility;Follicle Stimulating Hormone;Follicle Stimulating Hormone Receptor;G-Protein-Coupled Receptors;Gene Expression Profile;Genes;Genitourinary system;Glycoproteins;glycosylation;Goals;Gonadotropins;granulosa cell;Hormonal;Hormones;Human;hypothalamic pituitary gonadal axis;Immunoassay;Impairment;In Vitro;in vitro activity;in vivo;Incubated;Individual;infertility treatment;inhibin;Knockout Mice;Knowledge;Ligand Binding;Ligand Binding Domain;Luteinizing Hormone;Measures;Mediating;Medicine;member;Menstrual cycle;Molecular Conformation;Morbidity - disease rate;mullerian-inhibiting hormone;novel;Obesity;older women;Oligosaccharides;Outcome;Ovarian;Ovarian Follicle;Ovary;Pathway interactions;Pattern;Perimenopause;Pharmaceutical Preparations;Physiological;Pituitary Gland;Polysaccharides;Population;Positioning Attribute;Primates;programs;psychologic;receptor;receptor binding;receptor function;receptor-mediated signaling;recruit;reproductive;reproductive senescence;Resistance;response;Rhodopsin;Role;Rotation;Serum;Signal Transduction;Site;Steroids;Structure;Thyrotropin Receptor;Time;tool;Transgenic Organisms;translational potential;Transmembrane Domain;Urine;Uterine hemorrhage;Variant;vasomotor symptoms;Woman;young woman

PROJECT_TITLE: Project 4: Age-Related Changes in Gonadotropin Glycosylation and Function


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: SAN FRANCISCO

ORG_NAME: J. DAVID GLADSTONE INSTITUTES

ORG_STATE: CA

PHR: PROJECT NARRATIVE Alzheimer’s Disease progression is characterized by cellular expression of ApoE4, reduced metabolism in the central nervous system, and protein pathologies involving Tau and Amyloid-Beta. The roles of neuronal glucose metabolism and neuronal ApoE4 in Alzheimer’s Disease development are not well understood due to both the complex metabolic interactions between neurons and glia. We will therefore clarify the role of neuronal metabolism in the progression of Alzheimer’s Disease through a combination of genomics, metabolomics, and targeted validation of these changes through quantification of protein-level changes and intracellular ATP levels, enabling us to capture a complete picture of how neurons metabolically respond to their expression of ApoE4.

PI_NAMEs: SEI, YOSHI  (contact)

PROJECT_TERMS: Acceleration;Affect;Age;Age Months;age related changes;age-related disease;Aging;Alleles;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease model;Alzheimer's disease patient;Alzheimer's disease risk;Alzheimer's disease therapy;Amyloid beta-Protein;Amyloid beta-Protein Precursor;Apolipoprotein E;apolipoprotein E-3;apolipoprotein E-4;Arctic mutation;Arctic Regions;Astrocytes;behavior test;Bioenergetics;Bioinformatics;Biological Markers;Biology;Biosensor;Brain;Brain region;C57BL/6 Mouse;Carbohydrates;Catabolism;Catalogs;Cell Count;Cell Survival;Central Nervous System;Clustered Regularly Interspaced Short Palindromic Repeats;Communities;Complex;conditional knockout;Consumption;CRISPR interference;CRISPR-mediated transcriptional activation;Data;Dementia;Development;differential expression;Disease Progression;emerging adult;Exhibits;Fluorescence Resonance Energy Transfer;fluorodeoxyglucose positron emission tomography;Future;Gene Expression;Genes;Genomics;Glucose;glucose metabolism;Glucose Transporter;glucose uptake;GLUT-3 protein;Goals;Healthcare;Hippocampus;Human;human induced pluripotent stem cells;Image;Immunofluorescence Immunologic;Impaired cognition;Impairment;improved;In Situ;In Vitro;in vivo;in vivo Model;Individual;Induced pluripotent stem cell derived human neuron;Induced pluripotent stem cell derived neurons;insight;Insulin Receptor;insulin signaling;interest;Knock-in;Label;late life;Link;Manufacturer;Measures;Memory impairment;Mentors;Mentorship;Messenger RNA;Metabolic;Metabolic dysfunction;metabolic phenotype;Metabolism;metabolome;metabolomics;middle age;Mitochondria;Modeling;mouse model;Mus;mutant;Mutation;Nerve Degeneration;Neurodegenerative Disorders;Neuroglia;neuronal metabolism;Neurons;novel therapeutics;Output;Pathology;Pathway interactions;Patients;Positron-Emission Tomography;programs;Protein Isoforms;Proteins;Recovery;Research;Risk;Risk Factors;Role;Science;Senile Plaques;stem cells;symposium;Symptoms;targeted biomarker;tau Proteins;Testing;therapeutic candidate;therapeutic target;Time;trafficking;Training;transcriptomics;Transgenic Mice;translational potential;Universities;Validation;Work

PROJECT_TITLE: Understanding how neuronal glucose metabolism changes in AD due to ApoE4


ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE: Clinicians emerging from interdisciplinary fields including medicine, psychology, nursing and rehabilitation sciences are deeply familiar with the unmet needs of older adults and individuals with persistent or serious illness, yet they lack the necessary research methods training, mentorship and support to pursue rigorous clinical behavioral preventive health research. The proposed postdoctoral training program will provide a solution to this problem by providing talented MD and PhD trainees with world-class, interdisciplinary research training in clinical behavioral preventive health intervention development following the NIH Stage Model and Center for Disease Prevention framework of primary, secondary and tertiary prevention.

PI_NAMEs: RITCHIE, CHRISTINE S (contact);VRANCEANU, ANA-MARIA

PROGRAM_OFFICER_NAME: TORRES, DELANY

PROJECT_TITLE: Bridging the Science-to-Service Gap in Aging Care: Prevention, Optimization and Living Well with Persistent or Serious Illnesses


NIH_SPENDING_CATS: Biotechnology;Congenital Structural Anomalies;Eye Disease and Disorders of Vision;Genetics;Pediatric

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

ORG_STATE: NY

PHR: PROJECT NARRATIVE Lens cataract originates from disrupted lens microarchitecture and is a major cause of worldwide blindness. The majority of cataracts are caused by mutations in all crystallin genes, DNA-binding transcription factors (e.g. PAX6, MAF and HSF4), RNA-binding proteins (TDRD7 and Rbm24), and through mutations in 5’-UTRs of lens expressed genes (ferritin light chain FTL and solute transporter SLC16A12). Novel non-coding mutations in crystallin and other loci encoding abundant lens proteins remain poorly understood and this proposal will add insights into the function of non-coding cis-acting regulatory regions that will facilitate interpretation of human GWAS studies.

PI_NAMEs: CVEKL, ALES  (contact)

PROGRAM_OFFICER_NAME: ARAJ, HOUMAM H

PROJECT_TERMS: 3' Untranslated Regions;3-Dimensional;Binding;Biological;Birth;Blindness;Cataract;Cell Differentiation process;Cell Nucleus;cell type;Cells;Chromatin;Code;Complex;congenital cataract;Coupled;Crystallins;Cytoplasm;Data;Degenerative Disorder;design;Development;DNA;DNA Binding;DNA Modification Process;Embryo;Event;Eye;Ferritin;fiber cell;Gene Expression;Gene Expression Regulation;Genes;Genetic;Genetic Transcription;genome wide association study;Genomics;Goals;Growth Factor;Homeostasis;Human;in vivo;in vivo Model;Individual;insight;Knowledge;lens;Lens development;Lens Fiber;lens morphogenesis;Life Cycle Stages;Light;Link;Messenger RNA;Modeling;Molecular;mRNA Translation;Mus;Mutate;Mutation;novel;Nuclear;Nuclear Export;Nucleic Acid Regulatory Sequences;Outcome Study;Pathway interactions;Post-Transcriptional Regulation;Post-Translational Protein Processing;posttranscriptional;Process;programs;promoter;Protein Region;Proteins;Proteomics;regenerative therapy;Regulation;Regulatory Element;Research;Resolution;RNA;RNA Splicing;RNA-Binding Proteins;single molecule;Site;solute;Spatial Distribution;Structure;System;Testing;Tissue-Specific Gene Expression;Tissues;transcription factor;transcriptomics;Transgenic Organisms;Translations;Untranslated Regions;Untranslated RNA;Visualization

PROJECT_TITLE: Developmental regulation of lens gene expression

STUDY_SECTION: BVS

STUDY_SECTION_NAME: Biology of the Visual System Study Section[BVS]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: ATLANTA

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE WINSHIP CANCER INSTITUTE OF EMORY UNIVERSITY CANCER CENTER SUPPORT GRANT As the only NCI-designated comprehensive cancer center in Georgia, Winship Cancer Institute of Emory University (Winship) serves as the primary institution for cancer care, research, training, and education for the state. Winship's mission is to discover cures for cancer and inspire hope. Research conducted by Winship has directly contributed to FDA approval of new anti-cancer agents, first-in-human clinical trials, new national clinical trials and health care policy changes in the state of Georgia. Winship aims to: (1) conduct transformative research; (2) accelerate the translation of Winship member discoveries; (3) reduce the burden of cancer in its catchment area; and (4) promote education, training, and mentorship.

PI_NAMEs: RAMALINGAM, SURESH S (contact)

PROGRAM_OFFICER_NAME: HE, MIN

PROJECT_TERMS: Acceleration;Address;anti-cancer research;Area;Award;Basic Science;Black Populations;Cancer Burden;cancer care;Cancer Center Support Grant;cancer health disparity;Cancer health equity;Catchment Area;Clinical;clinical care;Clinical Sciences;Clinical Trials;Communication;community engagement;community organizations;Community Outreach;community partners;community partnership;Comprehensive Cancer Center;Country;Diagnosis;Disease;Early Therapeutic-Clinical Trials Network;Education;Education and Outreach;equity, diversity, and inclusion;experience;first-in-human;Fostering;Funding;Growth;Health;health literacy;Health Policy;Health Promotion;Hispanic Populations;HIV;Human Papilloma Virus Vaccination;improved;Individual;Infrastructure;innovation;Institution;Intervention;Investments;Leadership;leukemia/lymphoma;Malignant neoplasm of lung;Malignant Neoplasms;Manuscripts;member;Mentorship;Mission;Multiple Myeloma;novel anticancer drug;Patients;Peer Review;Phase;phase I trial;Population Sciences;programs;Publishing;Quality of life;Reporting;Research;Research Personnel;Resource Sharing;Resources;Risk;Rural;Schools;Science;Screening for cancer;Societies;Specialized Center;Statutes and Laws;Strategic Planning;Time;tobacco control;Training;Training and Education;Translational Research;Translations;treatment trial;tumor immunology;Underrepresented Populations;Underserved Population;United States;Universities

PROJECT_TITLE: Winship Cancer Institute Cancer Center Support Grant

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: Most behavioral weight-loss interventions have had mixed outcomes, with interventions failing to make a substantial or persistent difference in racial/ethnic minority populations. This may be secondary to neglecting the influence of an individual’s social environment. The results of this feasibility randomized control trial will result in a multi-level intervention that targets individual and network-level barriers to weight loss.

PI_NAMEs: PHILLIPS, ERICA  (contact)

PROGRAM_OFFICER_NAME: HALES, CRAIG MAURICE

PROJECT_TERMS: Address;Adoption;Adult;adult obesity;Affect;arm;Asian population;Behavior;behavior change;Behavioral;Black race;black women;Body mass index;Body Weight Changes;Body Weight decreased;Characteristics;Clinical;Clinical Trials;commune;Communication;comparison control;Control Groups;coping;Data;design;Diabetes Mellitus;Diet;Diffusion;Disease;Educational process of instructing;Enrollment;Environmental Risk Factor;ethnic minority;ethnic minority population;Ethnic Population;experience;Failure;Family;Feasibility Studies;Friends;Glycosylated hemoglobin A;Goals;good diet;Health;Health behavior;Healthy Eating;high risk;high risk population;Hispanic;Home;improved;Individual;Insulin Resistance;interpersonal conflict;Intervention;intervention effect;Intervention Studies;Knowledge;Life Style;lifestyle intervention;Link;Literature;Measurement;Measures;member;Metabolic;Mission;National Heart, Lung, and Blood Institute;National Institute of Diabetes and Digestive and Kidney Diseases;neglect;Non-Insulin-Dependent Diabetes Mellitus;Not Hispanic or Latino;Obesity;obesity risk;obesity treatment;Outcome;Participant;Pattern;Persons;Phenotype;Physical activity;Population;prevent;primary outcome;Process;promote resilience;prospective;Race;racial difference;racial minority;racial minority population;Randomized;Randomized, Controlled Trials;recruit;Recurrence;response;Risk;Secondary to;social;Social Environment;social factors;Social Network;social norm;Social support;Structure;Testing;Thinking;Time;Weight;Weight Gain;weight loss intervention

PROJECT_TITLE: Reducing Obesity Using Social Ties (ROBUST)

STUDY_SECTION: LCBH

STUDY_SECTION_NAME: Lifestyle Change and Behavioral Health Study Section[LCBH]


NIH_SPENDING_CATS: Cancer;Prevention

PI_NAMEs: KERSTANN, KIMBERLY FOWLER (contact)

PROJECT_TERMS: Achievement;Address;anti-cancer research;Area;Award;Basic Science;Cancer Center;Cancer Center Support Grant;cancer prevention;cancer survival;career;career development;Caring;Catchment Area;Cells;Clinical;Clinical Oncology;Clinical Research;Clinical Sciences;Clinical Trials;Communication;Communities;community engagement;Community Outreach;cost;cost effective;Custom;Data;Decision Making;Dedications;design;Development;Disease;Doctor of Philosophy;Education;Ensure;Environment;Equipment;equity, diversity, and inclusion;Evaluation;experience;Faculty;faculty support;Fostering;Funding;Funding Opportunities;Goals;Grant;Growth;hospital bed;Human Resources;Informatics;Information Technology;Infrastructure;innovation;inter-institutional;Interdisciplinary Study;Investigation;Laboratories;Leadership;Lung;Malignant Neoplasms;manufacturing facility;meetings;member;Mentors;Mission;Monitor;National Clinical Trials Network;novel;Office of Administrative Management;operation;Participant;Patients;Phase;Philanthropic Fund;Play;Population;Population Sciences;prevent;Process;programs;recruit;Regulation;Reporting;Research;Research Activity;research and development;Resource Sharing;Resources;response;Role;Services;Site;sound;Strategic Planning;Training;Training Activity;Training and Education;translational cancer research;Underrepresented Populations;Universities;Vision;working group

PROJECT_TITLE: Admin Core


NIH_SPENDING_CATS: Genetics;Infectious Diseases;Lyme Disease;Tickborne Diseases;Vector-Borne Diseases

ORG_CITY: WALTHAM

ORG_NAME: BRANDEIS UNIVERSITY

PHR: PROJECT NARRATIVE Cancer cells that display profound genome instability have often lost their ability to repair chromosome double-strand breaks (DSBs) by the accurate processes of homologous recombination; they also have lost their ability to activate the DNA damage response, which arrests cell cycle progression. This proposal investigates the mechanisms of repairing DSBs by homologous recombination and the interrelationship between DNA repair and the DNA damage response, primarily using budding yeast. This grant will also allow investigation of the poorly understood homologous recombination mechanisms that underlie the ability of the Lyme disease bacterium, Borrelia burgdorferi, to escape immune surveillance.

PI_NAMEs: HABER, JAMES E (contact)

PROGRAM_OFFICER_NAME: REDDY, MICHAEL K

PROJECT_TERMS: Affect;Area;Bacteria;Biochemistry;Biological Models;Borrelia;Borrelia burgdorferi;cancer cell;Cell Cycle Arrest;Cell Cycle Progression;Cells;Chromosomal Breaks;Chromosomes;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;DNA Damage;DNA damage checkpoint;DNA Repair;Double Strand Break Repair;Event;Funding;Gene Conversion;Genes;Genetic Recombination;Genomic Instability;Goals;Grant;homologous recombination;Human;Immunologic Surveillance;in vivo;insight;Investigation;Lyme Disease;Malignant Neoplasms;Mammalian Cell;Mediating;Molecular;Monitor;Mutation;National Institute of General Medical Sciences;Process;Pseudogenes;repaired;Research;response;Saccharomycetales;Signal Transduction;Single-Stranded DNA;Site

PROJECT_TITLE: DNA damage response and repair of a broken chromosome

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


NIH_SPENDING_CATS: Cancer

PI_NAMEs: BOISE, LAWRENCE H. (contact)

PROJECT_TERMS: American Cancer Society;anti-cancer research;Award;Basic Science;Cancer Biology;Cancer Burden;Cancer Center Support Grant;career;career development;Caring;Catchment Area;Clinical Oncology;Clinical Sciences;Communities;Continuing Education;Development;Discipline;Doctor of Philosophy;Education;education research;Educational Activities;Ensure;experience;Faculty;Fellowship Program;Funding;Future;Goals;graduate school;Grant;Institution;Investments;junior high school;Leadership;Malignant Neoplasms;Medicine;member;Mentored Clinical Scientist Development Program;Mentors;Mentorship;next generation;Outcome;Physicians;Population Sciences;Postdoctoral Fellow;Prevention;Process;Program Development;programs;Reporting;Research;Research Ethics;Research Personnel;Research Project Grants;Research Support;Research Training;Resource Sharing;Resources;Scientist;Students;success;Training;Training and Education;training opportunity;Training Programs;Translational Research;undergraduate student;Underrepresented Populations;Universities

PROJECT_TITLE: Cancer Research Training & Education Coordination


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Rural Health;Women's Health Research

PI_NAMEs: GONZALEZ, ILDEMARO  (contact)

PROJECT_TERMS: Acceleration;anti-cancer research;Asian;Belief;Black race;cancer care;Cancer Center;Cancer Center Support Grant;Cancer Science;career;Career Mobility;Catchment Area;college;Communities;Creativeness;Data;Dedications;demographics;Development;Diverse Workforce;Education;Ensure;equity, diversity, and inclusion;Evaluation;Faculty;Fostering;Future;Goals;Growth;Hispanic;Hispanic Populations;Historically Black Colleges and Universities;improved;Individual;Infrastructure;Leadership;leadership development;Lesbian Gay Bisexual Transgender Queer;low socioeconomic status;Malignant Neoplasms;Measurement;Measures;member;Mentorship;Minority;Mission;NCI Center for Cancer Research;Oncology;Outcome;Prevention;Process;Program Development;programs;Race;Research;Research Personnel;Resource Sharing;Resources;rural area;Teacher Professional Development;trend;Underrepresented Populations;Universities;Woman

PROJECT_TITLE: Plan to Enhance Diversity


NIH_SPENDING_CATS: Aging;Genetics;Osteoporosis

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE The public health relevance of age-related osteoporosis is enormous, since the condition affects more than 10 million Americans over 50 and causes about 2 million fractures yearly; the latter are associated with pain, loss of independence, and high mortality. Presently only a minority of patients with osteoporosis receive treatment, because few appropriate therapies are available, and because of both patients’ and physicians’ fear of serious side effects. We identified a novel cross-talk between the nitric oxide/cGMP/protein kinase G (PKG) signaling pathway and the protein sirtuin-1, a master-regulator of cellular and organismal aging; we now propose to combine pharmacological activation of PKG and sirtuin-1 to develop a new anabolic treatment strategy for age-related osteoporosis.

PI_NAMEs: PILZ, RENATE B (contact)

PROGRAM_OFFICER_NAME: WILLIAMS, JOHN

PROJECT_TERMS: Affect;Age;age related;age-related disease;Age-Related Osteoporosis;aged;Aging;American;analog;Antioxidants;Apoptosis;Architecture;beta catenin;bone;Bone Formation Stimulation;bone loss;bone mass;Bone Resorption;bone strength;Cell Aging;Clinical Trials;cobinamide;Cyclic AMP-Dependent Protein Kinases;Cyclic GMP;Cyclic GMP-Dependent Protein Kinases;Deacetylase;Diabetic mouse;Disease;DNA Damage;Effectiveness;FDA approved;Feedback;Foundations;Fracture;Fright;G-Protein Signaling Pathway;G-substrate;Gene Expression Profile;Genes;Genetic;Goals;Guanylate Cyclase;Impairment;improved;Induction of Apoptosis;Insulin-Dependent Diabetes Mellitus;interest;Knock-out;Knockout Mice;Knowledge;Lead;Longevity;male;Mediating;men;Mesenchymal Stem Cells;Messenger RNA;Metabolic;Minority;Mitochondria;mitochondrial dysfunction;mortality;mRNA Expression;Mus;neutralizing antibody;nicotinamide-beta-riboside;Nitric Oxide;Nitric Oxide Donors;Nitric Oxide Synthase;NOS3 gene;novel;novel therapeutics;Nuclear;old mice;osteoblast differentiation;Osteoblasts;Osteoclasts;Osteocytes;Osteogenesis;Osteoporosis;osteoporosis with pathological fracture;Osteoporotic;Ovariectomy;overexpression;Oxidative Stress;Oxidative Stress Induction;Pain;Patients;Pharmaceutical Preparations;pharmacologic;Phosphorylation;Physicians;posttranscriptional;prevent;protein activation;protein expression;Proteins;public health relevance;Regulation;Ribonucleoproteins;RNA-Binding Proteins;Role;senescence;side effect;Signal Pathway;Signal Transduction;SIRT1 gene;Sirtuins;skeletal;Testing;Transgenic Organisms;treatment strategy;Wild Type Mouse;Woman;Work

PROJECT_TITLE: PKG Regulation of Sirtuin 1 as a Novel Treatment Strategy for Age-related Osteoporosis

STUDY_SECTION: SBDD

STUDY_SECTION_NAME: Skeletal Biology Development and Disease Study Section[SBDD]


NIH_SPENDING_CATS: Cancer;Genetics

PI_NAMEs: ZHOU, WEI  (contact)

PROJECT_TERMS: Adhesions;anti-cancer research;Arts;Automobile Driving;Award;Basic Cancer Research;Basic Science;behavioral response;Biochemical;Biochemistry;Biological;Biological Markers;Biology;Biomechanics;Cancer Biology;cancer cell;Cancer Center Support Grant;cancer genetics;Cancer Patient;cancer prevention;Cancer Survivor;cancer therapy;cancer type;career;Caring;Catchment Area;Cell Adhesion;Cell Death;Cell Survival;Cells;Cellular biology;Cessation of life;Chromatin;Clinic;Clinical;Clinical Trials;Collaborations;collaborative environment;college;Communication;community engagement;Community Outreach;Development;DNA Modification Process;Doctor of Philosophy;Drosophila genus;Drug resistance;Education;Educational process of instructing;Environment;Epigenetic Process;Excess Mortality;Fellowship;first-in-human;Fostering;Foundations;Funding;Gene Expression;Gene Expression Regulation;Genetic;Glioma;Grant;high school;histone modification;Homeostasis;Immune Evasion;Immunotherapeutic agent;improved outcome;Infrastructure;inhibitor;innovation;inter-institutional;Invaded;Journals;junior high school;Lead;Leadership;Lung;Malignant neoplasm of lung;Malignant Neoplasms;MCL1 gene;Mediator;medical schools;member;Metabolic;metabolic abnormality assessment;Mission;Modeling;Molecular;Molecular Biology;Multiple Myeloma;Mutate;Neoplasm Metastasis;neoplastic cell;novel;novel therapeutic intervention;Patient-Focused Outcomes;Peer Review;Phase I/II Clinical Trial;Physiological;preclinical development;programs;Public Health Schools;Publications;Publishing;rapid growth;Reporting;Research;research clinical testing;Research Personnel;Research Training;Resistance;Resource Sharing;Risk;Science;Signal Pathway;Signal Transduction;STK11 gene;success;targeted treatment;Therapeutic Intervention;therapeutic target;Training and Education;Translating;Translational Research;Translations;treatment response;tumor;tumor growth;tumor metabolism;Tumor Promotion;tumorigenesis;Underrepresented Populations;Universities;Untranslated RNA;Vertebral column;Work

PROJECT_TITLE: Cell and Molecular Biology Research Program


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Cardiovascular;Complementary and Integrative Health;Congenital Heart Disease;Congenital Structural Anomalies;Dietary Supplements;Foodborne Illness;Heart Disease;Nutrition;Pediatric;Prevention;Rare Diseases

ORG_CITY: HOUSTON

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: Narrative We will study mothers who frequently eat fish, salad dressing and other foods that contain healthy fats. These fats are also called omega 3's. This study will determine whether eating foods containing healthy fats will help to prevent mothers from having babies with birth defects.

PI_NAMEs: WALLER, DOROTHY KIM (contact)

PROGRAM_OFFICER_NAME: ROSS, SHARON A

PROJECT_TERMS: Abbreviations;Acids;Address;Algae;alpha-Linolenic Acid;Area;Arthritis;bioaccumulation;Brain;Carbon;Case/Control Studies;Clinical;Code;Confidence Intervals;Congenital Abnormality;Congenital Heart Defects;Consumption;Country;Data;Databases;Diet;dietary;Dietary intake;dietary supplements;Disease;Docosahexaenoic Acids;docosapentaenoic acid;Eating;Eicosapentaenoic Acid;Environmental Pollutants;Fatty acid glycerol esters;Fishes;Folic Acid;Food;Frequencies;Funding Mechanisms;heart defect;Heart Diseases;Human;Hypertension;Infant;Intake;Interview;Link;manufacture;marine;Measures;methyl group;Modeling;mother nutrition;Mothers;Neural Tube Defects;Nurses' Health Study;Nutrient;Odds Ratio;offspring;Oils;Omega-3 Fatty Acids;Phenotype;pi bond;Plant Sources;Plants;Polyunsaturated Fatty Acids;Population Study;Pregnancy;prevent;Prevention;Questionnaires;Recommendation;Reporting;Research;response;Risk;Seafood;Site;Source;Soybeans;Sterile coverings;Subgroup;Testing;Tissues;Vinegar;Woman

PROJECT_TITLE: Maternal dietary intake of omega 3 fatty acids and birth defects

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Pediatrics Study Section[CHHD-A]


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Climate-Related Exposures and Conditions;Contraception/Reproduction;Infertility;Women's Health Research

ORG_CITY: Newark

ORG_DEPT: PHARMACOLOGY

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: PROJECT NARRATIVE The goal of this project is to use microfluidic follicular cultures to identify novel mechanisms of ovarian toxicity (ovotoxicity) for established chemicals and emerging harmful algal bloom (HAB) toxins. These studies are critically important to reveal novel insight into chemical-induced ovotoxicity and prioritize chemicals of high ovotoxicity concern, including HAB toxins, for further risk assessment.

PI_NAMEs: XIAO, SHUO  (contact)

PROGRAM_OFFICER_NAME: SCHUG, THADDEUS

PROJECT_TERMS: 3-Dimensional;Acceleration;aged;Alginates;Animal Testing;Animals;Architecture;biobank;Biological Assay;Chemicals;consumer product;Consumption;cost;Cryopreservation;Development;Encapsulated;Endocrine Disruptors;Environment;environmental chemical;Environmental Impact;Exhibits;Female;Fertilization;Germ Cells;girls;Goals;Gonadal Steroid Hormones;Gonadal structure;Growing Follicle;Growth;harmful algal blooms;Health;Hepatic;Hepatocyte;Hormone imbalance;Hormone secretion;Human;Hydrogels;Image;In Vitro;in vitro Model;Infertility;Injury;innovation;innovative technologies;insight;Laboratories;Liver;liver metabolism;Luteinization;Menstrual cycle;Methods;Microarray Analysis;microfluidic technology;Microfluidics;Microscopy;Modeling;Molecular;Molecular Profiling;Monitor;Morphology;Mus;neonatal mice;novel;oocyte maturation;Oocytes;Organ;Organ Culture Techniques;Ovarian;Ovarian Follicle;Ovarian Tissue;Ovary;ovotoxicity;Ovulation;Pattern;peptide hormone;Pharmacologic Substance;Physiological Processes;Premature Menopause;Premature Ovarian Failure;prepuberty;preservation;Primordial Follicle;reproductive;reproductive outcome;reproductive toxicity;Research;Risk;Risk Assessment;screening;Signal Transduction;System;Testing;Time;Toxic effect;Toxic Environmental Substances;toxicant;Toxicity Tests;Toxin;transcriptome sequencing;Transgenic Mice;Translating;United States National Institutes of Health;validation studies;Woman

PROJECT_TITLE: An ovary-on-a-chip to identify ovarian toxicity

STUDY_SECTION: ICER

STUDY_SECTION_NAME: Integrative and Clinical Endocrinology and Reproduction Study Section[ICER]


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunotherapy;Orphan Drug;Rare Diseases

PI_NAMEs: DHODAPKAR, MADHAV V (contact)

PROJECT_TERMS: Achievement;Acute Graft Versus Host Disease;Address;Antigen-Presenting Cells;antigen-specific T cells;Antigens;Award;B-Lymphocytes;Barbering;Basic Cancer Research;Basic Science;Biology;Cancer Burden;Cancer Center Support Grant;cancer health disparity;cancer immunotherapy;Cancer Patient;cancer risk;career development;Catchment Area;CD8-Positive T-Lymphocytes;Cell Therapy;Cellular biology;Clinical;clinical development;Clinical Investigator;Clinical Research;clinical translation;Clinical Trials;Collaborations;Communication;Communities;community engagement;Community Outreach;Correlative Study;cytokine;design;Development;Direct Costs;Doctor of Philosophy;Environment;Excess Mortality;exhaustion;Faculty;Fostering;Foundations;Funding;Goals;Growth;Head and Neck Cancer;Home;Immune;immune checkpoint blockade;immune modulating agents;Immune response;Immune system;Immunologic Memory;Immunologic Monitoring;immunological intervention;Immunologics;Immunologist;Immunology;Immunotherapeutic agent;Immunotherapy;improved outcome;Infrastructure;innovation;insight;Institution;inter-institutional;Journals;Leadership;leukemia/lymphoma;Malignant neoplasm of lung;Malignant Neoplasms;Mediating;medical schools;meetings;member;Mission;Molecular;mortality disparity;Multiple Myeloma;Natural Immunity;Nature;next generation;Outcome;Patients;PD-1 pathway;PD-1/PD-L1;PDL1 pathway;Peer Review;Physicians;Plasma Cells;Play;Populations at Risk;prevent;Process;programmed cell death protein 1;programs;Publications;Publishing;Regulation;Reporting;Research;Research Personnel;Resource Sharing;Resources;response;Role;Science;Scientist;Seminal;Societies;Specialized Center;Structure;System;T-Lymphocyte;T-Lymphocyte Subsets;Testing;Therapeutic;Training;Translating;Translational Research;Translations;tumor;Tumor Immunity;tumor immunology;tumor microenvironment;tumor-immune system interactions;Universities;Work

PROJECT_TITLE: Cancer Immunotherapy Research Program


ORG_DEPT: GENETICS

PHR: Project Narrative The Genetics Predoctoral Training Program (GPTP) at Emory University trains students from diverse backgrounds in genetics, genomics and molecular biology. Through a rigorous yet flexible curriculum, dissertation research and customized career development training plans aligned to individual student competency-based assessments, students are prepared to obtain and succeed in the career of their choice within the biomedical workforce.

PI_NAMEs: CASPARY, TAMARA J. (contact)

PROGRAM_OFFICER_NAME: AIYEGBO, MOHAMMED S

PROJECT_TERMS: Genetic;pre-doctoral;Training Programs

PROJECT_TITLE: Genetics Predoctoral Training Program

STUDY_SECTION_NAME: Training and Workforce Development Study Section - A[TWD-A]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Diabetes

ORG_CITY: Aurora

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: NARRATIVE Diabetes is a global heath epidemic, and bioengineering approaches and new technology are needed to advance the development of effective diagnostics, management strategies and cures for diabetes. However there is a shortage of a skilled scientific workforce able to work on these developments, due to the unique training required. We will leverage the outstanding previous experience, expertise, resources and institutional support at the University of Colorado to develop such a training program, in order to attract and train outstanding PhD students, to prepare them for outstanding research careers in academia and industry.

PI_NAMEs: BENNINGER, RICHARD KP (contact);HASKINS, KATHRYN M

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Biomedical Engineering;Diabetes Mellitus;Research Training

PROJECT_TITLE: Interdisciplinary Bioengineering Research Training in Diabetes

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


ORG_CITY: KNOXVILLE

ORG_NAME: UNIVERSITY OF TENNESSEE KNOXVILLE

PHR: PROJECT NARRATIVE Dynamics of mammalian progenitor cells and epithelial cells play crucial roles in normal development, physiology and cancer progression. The proposal aims to study the molecular and cellular mechanisms for the plasticity and lineage commitment of these cells in terms of underlying gene circuits, which will lead to better understanding of developmental diseases, degenerative diseases and cancers.

PI_NAMEs: HONG, TIAN  (contact)

PROGRAM_OFFICER_NAME: YU, GUOQIN

PROJECT_TERMS: Binding;cancer cell;cancer drug resistance;Cells;Computing Methodologies;Data;Degenerative Disorder;Development;developmental disease;Disease;Epithelial Cells;epithelial to mesenchymal transition;Epithelium;experimental study;Foundations;Gene Expression;Gene Expression Profile;gene regulatory network;Genes;Genetic Transcription;Heterogeneity;insight;lung cancer cell;Malignant Neoplasms;Mammalian Cell;mathematical model;Measurement;Mesenchymal;Methods;MicroRNAs;Modeling;Molecular;Motor Neurons;Neuronal Differentiation;non-genetic;novel;Pattern;Pattern Formation;Physiology;Play;posttranscriptional;Role;Signal Transduction;Site;Spinal Cord;stem;Stem Cell Factor;stem cells;success;System;Techniques;Testing;theories;Therapeutic;tissue degeneration;tumor;tumor progression

PROJECT_TITLE: Modeling transcriptional and post-transcriptional systems for regulating non-genetic heterogeneity in mammalian cells

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MGG-C(55)R]


PI_NAMEs: FU, HAIAN  (contact)

PROJECT_TERMS: ABCG2 gene;Acceleration;Acute Graft Versus Host Disease;Address;anti-cancer;Antineoplastic Agents;Automobile Driving;Award;bench to bedside;Cancer Burden;Cancer Center;Cancer Center Support Grant;Cancer Control;cancer diagnosis;Cancer Diagnostics;cancer imaging;Cancer Intervention;Cancer Patient;cancer prevention;cancer therapy;career;career development;Catchment Area;Cellular biology;Clinical;clinical care;clinical implementation;Clinical Research;Clinical Trials;Clinical Trials Design;Clinical Trials Network;Clinical Trials Unit;Collaborations;collaborative environment;Communication;Communities;community engagement;Community Outreach;Computer Models;Detection;Development;Developmental Therapeutics Program;Diagnostic;diagnostic development;diagnostic strategy;disorder prevention;Doctor of Philosophy;Drug Delivery Systems;drug discovery;Drug resistance;Environment;experience;faculty mentor;Feedback;first-in-human;Fostering;Funding;Genomics;Goals;high throughput screening;Human;Image;image guided;imaging agent;imaging probe;Imaging technology;Immunotherapeutic agent;Immunotherapy;improved;in vivo imaging;individualized medicine;Infrastructure;inhibitor;innovation;Intervention Trial;invention;Investigational Therapies;investigator-initiated trial;Journals;Lead;lead optimization;Leadership;Lung;Malignant neoplasm of prostate;Malignant Neoplasms;Manuscripts;Medical center;member;MERTK gene;Mission;Molecular Biology;multidisciplinary;nanofiber;nanoparticle;new therapeutic target;next generation;non-invasive imaging;noninvasive diagnosis;novel;novel anticancer drug;novel therapeutics;Patient-Focused Outcomes;Patients;Peer Review;Pharmaceutical Chemistry;Pharmacologic Substance;Phase;Phase I Clinical Trials;phase III trial;Play;Positioning Attribute;Positron-Emission Tomography;precision oncology;prevent;Productivity;programs;Publishing;Radioisotopes;Radiopharmaceuticals;randomized, clinical trials;Recurrence;Research;research clinical testing;Research Personnel;Resources;Science;single photon emission computed tomography;Site;small molecule;success;Synthesis Chemistry;Systems Biology;targeted cancer therapy;Teacher Professional Development;Technology;technology development;Testing;theranostics;Therapeutic;Therapeutic Agents;therapeutic development;therapeutic evaluation;Therapeutic Research;therapeutic target;Training;translational pipeline;Translational Research;Translations;tumor;tumor immunology;Underrepresented Populations

PROJECT_TITLE: Discovery and Developmental Therapeutics Research Program


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Burden of Illness;Clinical Research;Dementia;Disability Research;Genetics;Human Genome;Neurodegenerative;Neurosciences;Prevention;Rehabilitation

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Project Narrative The public health relevance of the proposed research derives from three fundamental questions in biogerontology and biodemography: (1) To what extent have increases in life expectancy at age 65 and above been accompanied by compression of morbidity/disability? (2) Can we uncover the underlying genetic pathways and modifiable non-genetic risk factors that contribute to enhanced or diminished degrees of morbidity/disability compression? (3) Can we use the insights, information, and understanding gained from questions 1 and 2 to further compress the period of morbidity/disability near the end of life through strategies designed to delay the manifestation of signs/symptoms of severe physical and/or cognitive impairment— including AD/ADRD?

PI_NAMEs: STALLARD, P.J. ERIC  (contact)

PROGRAM_OFFICER_NAME: BRAUDT, DAVID BRUCE

PROJECT_TERMS: Activities of Daily Living;Address;Age;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Arthritis;bead chip;biodemography;biogerontology;Blood;Blood specimen;Blood Vessels;Chronic Disease;Cognitive;comorbidity;Computer software;Constitution;Coupled;Data;data cleaning;Dementia;density;design;Diabetes Mellitus;disability;Disability outcome;disability risk;Disablement;DNA;DNA Methylation;Elderly;end of life;Epigenetic Process;Family Study;FOXO3A gene;Fracture;FRAP1 gene;gene network;Genes;Genetic;genetic analysis;genetic association;Genetic Databases;Genetic Polymorphism;Genotype;Health;Health and Retirement Study;Health Care Costs;health data;Health Insurance Portability and Accountability Act;Heart Diseases;Heterozygote;human old age (65+);Hybrid Vigor;Hypertension;IGF1 gene;Impaired cognition;improved;Incidence;indexing;Individual Differences;insight;instrumental activity of daily living;Insulin;Lewy Bodies;Life;Life Expectancy;life span;Link;Long-Term Care;Longevity;Malignant Neoplasms;Measures;Mental Depression;Methylation;middle age;modifiable risk;Morbidity - disease rate;mortality;non-genetic;Nucleotides;Obesity;Outcome Measure;Pathway interactions;Phenotype;physical impairment;physical inactivity;physically handicapped;Population;Population Study;Prevalence;Protocols documentation;Public Health;public health relevance;Reporting;Research;Resolution;Respondent;Risk Factors;Role;Sampling;Signal Transduction;Signs and Symptoms;Site;Smoking;SNP array;SOD2 gene;Stroke;Surveys;Testing;TP53 gene;trend;Triage;Uncertainty;United States;Variant;Whole Blood

PROJECT_TITLE: Genetic and Non-Genetic Modulators of Morbidity/Disability Compression in a Large Population-Based Study of Cognitive and Physical Impairment with Emphasis on Alzheimer's Disease and Related Dementias

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-C(51)]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Childhood Injury;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Unintentional Childhood Injury

ORG_DEPT: ANESTHESIOLOGY

PHR: Project narrative: The proposed research is relevant to public health because it provides a better understanding of the role of maternal infection and inflammation in the pathogenesis of neurodevelopmental disorders resulting in cognitive and learning deficits that would enable the development of specific targeted therapy for prevention of these disorders. Injury to the developing brain results in neurodevelopmental with large life time health care costs and very little treatment options. The works uses a translational research approach and is relevant to NIH’s mission to ensure application of knowledge to enhance health and reduce illness and disability.

PI_NAMEs: KANNAN, SUJATHA  (contact);RANGARAMANUJAM, KANNAN ;SLUSHER, BARBARA STAUCH

PROGRAM_OFFICER_NAME: DOPERALSKI, ADELE ELIZABETH

PROJECT_TERMS: Acids;Address;Adolescent;Age;Agonist;antagonist;Area;Association Learning;Birth;Blinking;Brain;Brain Injuries;Cell Count;Cells;Cerebellar Cortex;Cerebellar Diseases;Cerebellum;Cerebral Palsy;Child;clinical translation;Cognition;Cognitive;comparative efficacy;conditioning;cytokine;Data;Dendrimers;Development;disability;disorder prevention;Dose;efficacy evaluation;Electrophysiology (science);Endotoxins;Ensure;Enzymes;Etiology;excitotoxicity;Exhibits;Experimental Autoimmune Encephalomyelitis;Exposure to;eyeblink conditioning;fetal;FOLH1 gene;Functional disorder;glial activation;glutamate carboxypeptidase;Glutamates;Health;Health Care Costs;high risk;Histology;Human;hypoxic ischemic injury;Image;Impaired cognition;Impairment;improved;in utero;In Vitro;Infection;Inflammation;Inflammatory;inhibitor;Injury;innovation;intrauterine inflammation;Intravenous;Knowledge;Learning;Learning Disorders;Life;Link;Mediating;Memory;metabotropic glutamate receptor 3;Metabotropic Glutamate Receptors;Microglia;Mission;Modeling;motor deficit;motor disorder;mouse model;Mus;N-acetylaspartate;N-acetylaspartylglutamate;nanomedicine;nanomolar;natural hypothermia;Neonatal Brain Injury;neonatal care;neonatal encephalopathy;Neurocognitive;Neurodevelopmental Disorder;Neuroglia;neuroinflammation;Neurons;Neuropeptides;Neuropharmacology;neuroprotection;Neuropsychology;Newborn Infant;novel;novel therapeutics;Oryctolagus cuniculus;Output;overexpression;Pathogenesis;Pathology;Penetration;Pentanes;Perinatal;Perinatal Brain Injury;perinatal period;Phagocytosis;Play;postnatal;preadolescence;Premature Infant;prenatal exposure;Public Health;Purkinje Cells;receptor;Reflex action;Regulation;Research;response;Role;Saline;School-Age Population;Slice;spasticity;Survivors;targeted treatment;Testing;Therapeutic;Thick;Time;Translational Research;Translations;United States National Institutes of Health;Up-Regulation;Work

PROJECT_TITLE: Targeting glutamate carboxypeptidase in perinatal brain injury

STUDY_SECTION: BINP

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Kidney Disease;Urologic Diseases

ORG_CITY: COLUMBUS

ORG_NAME: RESEARCH INST NATIONWIDE CHILDREN'S HOSP

ORG_STATE: OH

PHR: PROJECT NARRATIVE Urinary tract obstruction is a leading cause of chronic kidney disease and end stage renal disease in children. The renal urothelium remodels in response to obstruction to protect the kidney from further injury. This proposal aims to identify molecular mechanisms governing urothelial development and repair and forms the foundation for novel therapeutic approaches to care for patients with urinary tract obstruction.

PI_NAMEs: JACKSON, ASHLEY R. (contact)

PROGRAM_OFFICER_NAME: RANKIN, TRACY L

PROJECT_TERMS: Ablation;Acceleration;Address;Advisory Committees;Attenuated;Automobile Driving;Bioinformatics;Biological Assay;Biological Models;Bladder;career;career development;cell age;Cell Differentiation process;cell injury;Cell Proliferation;Cell Separation;Cells;Cessation of life;Child;Childhood;Chronic;Chronic Kidney Failure;Cytoprotection;Data;Development;Disease;Disease Progression;End stage renal failure;Exhibits;Foundations;Functional disorder;Functional impairment;Funding;Future;Gene Expression Profile;Goals;In Vitro;in vivo;Injury;Injury to Kidney;Intervention;keratin 5;Kidney;Kidney Diseases;kidney dysfunction;Knowledge;Mentors;Modeling;Molecular;mortality;Mus;Natural regeneration;notch protein;Notch Signaling Pathway;novel;novel therapeutic intervention;Obstruction;Operative Surgical Procedures;Organoids;Outcomes Research;Pathway Analysis;Pathway interactions;Patient Care;Patients;pharmacologic;Physiology;Postdoctoral Fellow;prevent;progenitor;programs;Property;Publishing;Regulation;Renal function;repair function;repaired;Research;Research Personnel;response;response to injury;Role;Scientist;Signal Pathway;Signal Transduction;skills;Source;stem cells;Structure;targeted treatment;Testing;therapy development;Thinness;Time;Tissue Engineering;Training;transcriptome sequencing;Urinary tract;urinary tract obstruction;Urothelial Cell;Urothelium

PROJECT_TITLE: Defining the renal urothelium progenitor and its regulation during development and repair

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;HPV and/or Cervical Cancer Vaccines;Health Services;Immunization;Prevention;Social Determinants of Health;Tobacco;Tobacco Smoke and Health;Vaccine Related

PI_NAMEs: LASH, TIMOTHY L. (contact)

PROJECT_TERMS: Adherence;Adolescent;Affect;American Cancer Society;Area;Award;Behavior Therapy;Behavioral;Behavioral Sciences;biobehavior;Biological;Biological Markers;Biometry;Brain;burden of illness;Cancer Burden;cancer care;Cancer Center Support Grant;Cancer Control;Cancer Control Research Program;cancer diagnosis;cancer epidemiology;Cancer Etiology;Cancer Patient;cancer prevention;cancer risk;Cancer Survivor;Cancer Survivorship;Cardiovascular Diseases;career;Caring;Catchment Area;Centers for Disease Control and Prevention (U.S.);Childhood;Collaborations;Communities;community advisory board;community collaboration;community engagement;Community Outreach;community research;Data;Discipline;Discipline of Nursing;Disparity;DNA;Economics;Environment;Environmental Exposure;Epidemiology;Exposure to;Funding;Goals;Health;Health equity research;health organization;Healthcare;HPV vaccine acceptance;human disease;Human Papilloma Virus Vaccination;improved;Individual;Inequity;innovation;International;Intervention;Journals;Knowledge;Late Effects;Leadership;learning community;Malignant Neoplasms;medical schools;Medicine;member;Mission;neoplasm registry;next generation;Oncology;Outcome;Patient Outcomes Assessments;Peer Review;Policies;Population;Population Research;prevent;Prevention Research;Primary Care;programs;Public Health;Public Health Schools;Publishing;Quality of Care;Quality of life;recruit;Recurrence;reduce tobacco use;Research;Research Activity;Research Personnel;Research Training;Resource Sharing;Risk Factors;Risk Reduction;Rural;School Nursing;Scientist;social;Societies;Soot;Strategic Planning;success;Survivors;survivorship;symptom management;Symptoms;System;Technology;therapy development;tobacco control;Underrepresented Populations;Universities;ward;Weight Gain;weight gain prevention

PROJECT_TITLE: Cancer Prevention and Control Research Program


ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

PHR: Public Health Relevance Statement: The BRCA-mutant cancers retain key features of the underlying homologous recombination defect (HRD) or “BRCAness”, conferring a vulnerability to targeted therapies that induce replication stress and DNA damage. Our Program takes multidisciplinary approaches to better understand the mechanisms by which the BRCA network suppresses tumorigenesis and impacts therapeutic response, with a goal of improving the outcomes of tumors harboring HRD, which account for up to 12% of all human cancer cases.

PI_NAMEs: SHEN, ZHIYUAN  (contact)

PROGRAM_OFFICER_NAME: WITKIN, KEREN L

PROJECT_TERMS: Ablation;Address;Area;BARD1 gene;base;BRCA1 gene;BRCA2 gene;cancer therapy;Cells;chemotherapy;Chromatin;Chromosomal Stability;Chromosomes;Clinical;Collaborations;Complex;Data;Defect;design;Development;DNA biosynthesis;DNA Damage;DNA Repair;DNA replication fork;DNA Sequence;DNA Sequence Alteration;Epigenetic Process;Functional disorder;gene network;Generations;Genes;Genetic;Genetically Engineered Mouse;genome integrity;Genomic Instability;genomic signature;genomic tools;Genomics;Goals;homologous recombination;Human;Impairment;improved;improved outcome;In Vitro;inhibitor;insight;interdisciplinary approach;interest;Kinetics;loss of function;Malignant Breast Neoplasm;Malignant Neoplasms;Mammalian Cell;Mammary Neoplasms;MCM10 gene;Mediating;Medulloblastoma;member;Methods;Methylation;Modeling;Molecular;mouse model;Mus;Mutagenesis;mutant;Mutation;novel;novel therapeutics;p53-binding protein 1;PALB2 gene;Pathway interactions;Pattern;Pharmaceutical Preparations;Poly(ADP-ribose) Polymerase Inhibitor;predictive tools;Program Research Project Grants;programs;Proteins;public health relevance;recruit;Recurrence;Regulation;repaired;replication stress;Research;Research Personnel;Resolution;Resource Sharing;response;Role;Site;Structure;success;Sumoylation Pathway;targeted cancer therapy;targeted treatment;Therapeutic;tool;TOP1 gene;TOPBP1 Gene;treatment response;tumor;Tumor Suppression;tumorigenesis;ubiquitin-protein ligase;Ubiquitination

PROJECT_TITLE: Mechanisms of the BRCA-network in tumorigenesis and therapeutic response


NIH_SPENDING_CATS: Breast Cancer;Cancer;Genetics;Rare Diseases;Women's Health Research

PHR: PROJECT NARRATIVE Many types of cancer, especially breast, ovarian and pancreatic cancers, show genetic changes caused by defective DNA repair. This project will identify factors that control how DNA repair is regulated, so that new strategies can be identified to prevent or cure these types of cancer. In particular, we will study how an important repair factor, BRCA1, gets to DNA break sites to carry out repair, and prevent the appearance of cancer.

PI_NAMEs: BUNTING, SAMUEL  (contact)

PROJECT_TERMS: Address;Affect;Aging;Appearance;Automobile Driving;BARD1 gene;BRCA1 gene;BRCA1 Mutation;BRCA2 gene;Breast Cancer Cell;Breast Cancer Model;Breast Cancer Patient;Cancer Model;cancer type;cell growth;Cell Line;Cells;Chromatin;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;Complex;conditional knockout;Data;design;DNA;DNA biosynthesis;DNA Damage;DNA Double Strand Break;DNA Repair;DNA Repair Disorder;DNA Repair Gene;DNA replication fork;Double Strand Break Repair;effective therapy;Event;Gene Modified;Goals;Hereditary Breast and Ovarian Cancer Syndrome;homologous recombination;Incidence;Investigation;Knock-out;Knockout Mice;Literature;Malignant Breast Neoplasm;Malignant neoplasm of ovary;Malignant neoplasm of pancreas;Malignant Neoplasms;Mass Spectrum Analysis;Measures;Mediating;Mediator;Medulloblastoma;Methods;Microscopy;Modeling;mouse model;Mus;mutant;mutant mouse model;Mutation;novel;novel strategies;p53-binding protein 1;PALB2 gene;Pathologic;Pathway interactions;Pattern;Phenotype;Phosphorylation;Play;Poly(ADP-ribose) Polymerase Inhibitor;Post-Translational Protein Processing;Predisposition;prevent;Prevention;Productivity;protein complex;Protein Isoforms;Protein Methylation;Protein Methyltransferases;Proteins;Proteomics;recruit;Regulation;repaired;replication stress;Reporting;Research;response;Role;Scaffolding Protein;Signal Transduction;Site;Somatic Mutation;Sumoylation Pathway;Tertiary Protein Structure;Testing;Time;TOPBP1 Gene;TP53 gene;treatment response;tumor;Tumor Suppressor Proteins;tumorigenesis;Ubiquitin;ubiquitin-protein ligase;Ubiquitination;Work

PROJECT_TITLE: Project 1:  Recruitment of the BRCA1-associated Homologous Recombination Machinery


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Brain Disorders;Mental Health

ORG_CITY: BIRMINGHAM

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: This “Predoctoral Training in a Multifaceted Translational Approach to Mental Illness (AMI)” program is focused on providing training to highly motivated pre-doctoral students in the field of translational research in mental health. UAB has a large base of interdisciplinary faculty with interests centered in basic and clinical research, therapeutics and biomarkers, as well as genetics and functional genomics in the area of mental health. With the NIMH supported T32 program, our highly trained faculty, with the support of diverse resources and an enriched environment, are committed to provide an exceptionally strong mentoring framework to train the next generation of mental health researchers.

PI_NAMEs: DWIVEDI, YOGESH ;LAHTI, ADRIENNE C (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TITLE: Predoctoral Training in Multifaceted Translational Approach to Mental Illness


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Neurodegenerative;Neurosciences

ORG_CITY: BERKELEY

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: Project Narrative ! Converging lines of evidence provide compelling evidence that the functional domain of the cerebellum is not restricted to sensorimotor control, but extends to domains as diverse as perception, attention, language, and mathematics. To date, functional hypotheses have either been largely descriptive or targeted to account for cerebellar function in a relatively narrow, task-specific manner. The overarching goal of this research program is to take a more mechanistic approach, one designed to extend our understanding of cerebellar function across multiple task domains through the integrated use of behavioral and neuroimaging studies in healthy and neurologically impaired populations.

PI_NAMEs: IVRY, RICHARD  (contact)

PROGRAM_OFFICER_NAME: CHEN, DAOFEN

PROJECT_TITLE: Human Cerebellar Function in Multiple Task Domains


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hematology;Lung;Lung Cancer;Lymphatic Research;Lymphoma;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases;Rural Health;Social Determinants of Health

PI_NAMEs: GILLESPIE, THERESA W (contact)

PROJECT_TERMS: Address;Adoption;Advocate;African American;Age;anti-cancer research;Appointment;Black American;Black Populations;Black race;Bladder Lymphoma;Breast;Budgets;Cancer Burden;cancer care;Cancer Center;Cancer Center Support Grant;cancer health disparity;cancer prevention;cancer risk;Catchment Area;Clinical Trials;Clinical Trials Design;Collaborations;Colorectal;Communication;Communities;community advisory board;community collaboration;community engaged research;community engagement;Community Outreach;community partners;community partnership;community research;cost;County;Data Collection;design;Development;Disparity;disparity reduction;Doctor of Philosophy;Education;Ensure;Equity;Evidence based intervention;Excess Mortality;experience;Feedback;Fostering;Foundations;Funding;Goals;Health;HIV;Human Resources;Incidence;Income;Infrastructure;innovation;Institution;Insurance;interest;Intervention;Lung;Malignant neoplasm of pancreas;Malignant Neoplasms;Medicaid;Modeling;Monitor;mortality;Multiple Myeloma;Non-Hodgkin's Lymphoma;novel;novel strategies;Obesity;Outcome;Outcome Measure;outreach;Patients;Persons;Phase;Policies;Population;Population Study;Positioning Attribute;Poverty;Prevalence;Prevention Research;Process;programs;Prostate;public policy on tobacco;Recording of previous events;Regional Cancer;Registries;Research;Research Personnel;Research Priority;Research Proposals;Resources;Rest;Risk;rural dwellers;Scientist;screening;Series;Smoking;social health determinants;Special Population;Strategic Planning;symposium;System;tool;Translational Research;Translations;trial planning;Universities;Uterus;Vulnerable Populations;Work

PROJECT_TITLE: Community Outreach and Engagement


NIH_SPENDING_CATS: Biotechnology;Cancer;Hematology;Hodgkin's Disease;Immunotherapy;Lymphatic Research;Lymphoma;Orphan Drug;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_NAME: RESEARCH INST OF FOX CHASE CAN CTR

ORG_STATE: PA

PHR: PROJECT NARRATIVE (RELEVANCE TO PUBLIC HEALTH) This study is the first effort to investigate the deep mechanisms underlying the recurrent A20 mutations in Hodgkin lymphoma (HL) based upon results from a high-throughput CRISPR library screen. Gaining insight into the pathological roles of the A20-LUBAC axis in HL can lead to improved understanding of the molecular circuitry that drives tumor survival and immune escape. The therapeutic potential of targeting LUBAC will be tested using a highly specific LUBAC small molecular inhibitor, which is an approach that can provide novel intervention strategies for both targeted and immune therapies in this disease.

PI_NAMEs: YANG, YIBIN  (contact)

PROGRAM_OFFICER_NAME: JHAPPAN, CHAMELLI

PROJECT_TERMS: Address;Antigens;Apoptosis;B cell differentiation;B-Lymphocytes;Biological Assay;Biology;C-terminal;cell growth;Cell surface;Cell Survival;Cells;Clinical;Coculture Techniques;Complex;CRISPR library;CRISPR screen;cytokine;Development;Diagnosis;Disease;efficacy evaluation;Engraftment;Enzymes;Gene Expression Profiling;Genes;Growth;Hodgkin Disease;Human;Human Herpesvirus 4;humanized mouse;Immune;immune checkpoint;Immune checkpoint inhibitor;immune clearance;Immune response;Immune system;Immunotherapy;improved;In complete remission;In Vitro;in vivo;in vivo evaluation;Inflammatory;inhibitor;insight;Interleukin-13;Intervention;Knowledge;Libraries;loss of function;Lymphoma;Malignant - descriptor;Malignant lymphoid neoplasm;Mediating;Minority Groups;Molecular;molecular pathology;Mus;mutant;Mutation;mutational status;neoplastic cell;novel;novel strategies;novel therapeutic intervention;Outcome;Overlapping Genes;Pathogenesis;Pathologic;Pathway interactions;Patients;Peripheral Blood Mononuclear Cell;Phenotype;prevent;Process;Production;programmed cell death ligand 1;programs;Proliferating;Proteins;Proteomics;Public Health;rare cancer;Recurrence;Reed-Sternberg-like Cell;Refractory;Refractory Disease;Relapse;response;Role;Sampling;screening;Signal Transduction;small molecule inhibitor;STAT6 gene;Survival Rate;System;T-Cell Proliferation;targeted treatment;Testing;Therapeutic;therapeutic development;therapeutic target;therapeutically effective;TNFRSF8 gene;transcriptome sequencing;Translating;tumor;Tumor Escape;tumor growth;tumor initiation;tumor-immune system interactions;Ubiquitin;Ubiquitination;Xenograft Model;young adult;Zinc Fingers

PROJECT_TITLE: Analysis and Therapeutic Targeting of the Linear-Ubiquitination Pathway in Hodgkin Lymphoma

STUDY_SECTION: MONC

STUDY_SECTION_NAME: Molecular Oncogenesis Study Section[MONC]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Genetics;Human Genome;Women's Health Research

PHR: RELEVANCE TO PUBLIC HEALTH The proposed studies will elucidate the molecular mechanisms by which key tumor suppressors BRCA2 and BRCA1 regulate cancer cell response to chemotherapy and potentially reveal a significant cause of tumor relapse after chemotherapy. Results from this research may inform the rational design of new cancer therapies with higher potency and lower chance of tumor relapse.

PI_NAMEs: XIA, BING  (contact)

PROJECT_TERMS: Ablation;Address;Aftercare;Binding;BRCA deficient;BRCA1 gene;BRCA2 gene;Breast;Breast Cancer Cell;Breast Cancer cell line;Breast Cancer Risk Factor;cancer cell;Cancer Etiology;cancer therapy;Cell Proliferation;Cells;chemotherapy;ChIP-seq;Clinical;Clone Cells;combat;comparative efficacy;conditional knockout;Defect;Development;Disease;DNA;DNA biosynthesis;DNA Damage;DNA Double Strand Break;DNA lesion;DNA Repair;DNA Replication Factor;DNA replication fork;Double Strand Break Repair;Doxorubicin;Drug resistance;efficacy evaluation;Engineering;Fiber;gene product;Generations;Genes;genome sequencing;Genome Stability;Genomic Instability;Germ-Line Mutation;high risk;histone methyltransferase;homologous recombination;inhibitor;irinotecan;Kinetics;Knockout Mice;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Neoplasms;Mammary Tumorigenesis;MCM10 gene;Measures;Modeling;Molecular;mouse model;mutant;Mutation;Ovarian;PALB2 gene;Pancreas;Phenocopy;Phenotype;Platinum;Play;Poly(ADP-ribose) Polymerase Inhibitor;Prostate;Proteins;Public Health;radioresistant;rational design;recombinational repair;Regulation;Relapse;repaired;replication stress;Research;Resistance;response;restraint;Risk;Role;S phase;Salts;side effect;SLC19A1 gene;Speed;targeted treatment;Testing;Time;Topoisomerase;Topoisomerase Inhibitors;Topoisomerase-I Inhibitor;treatment response;triple-negative invasive breast carcinoma;tumor;Tumor Suppressor Proteins;tumorigenesis;Type I DNA Topoisomerases;whole genome;Xenograft procedure

PROJECT_TITLE: Project 2:  Targeting DNA replication in BRCA-associated breast cancer


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);HIV/AIDS;Harm Reduction for Substance Misuse;Infectious Diseases;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: PROVIDENCE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: PROJECT NARRATIVE On top of the persistent ~10% of new U.S. HIV infections that occur among people who inject drugs (PWID), recent HIV outbreaks in several areas of the United States including Massachusetts have caused renewed concern about HIV transmission in PWID, who often have overlapping injection and sexual risk. Despite the proven efficacy of pre-exposure prophylaxis (PrEP) and U.S. Preventive Services Task Force recommendation that PrEP be offered to PWID at risk for HIV, uptake in this socially marginalized population remains severely limited. A brief, multi-component behavioral intervention delivered to PWID by highsly trained PrEP Navigators embedded within syringe service programs has the potential to increase PrEP use among PWID, thus decreasing HIV incidence in this socially-marginalized population and reducing onward transmission to injecting and sexual partners.

PI_NAMEs: BAZZI, ANGELA ROBERTSON;BIELLO, KATIE BROOKS (contact)

PROGRAM_OFFICER_NAME: JENKINS, RICHARD A

PROJECT_TERMS: Adherence;Affect;Age;AIDS prevention;Anti-Retroviral Agents;Appointment;Area;Behavior Therapy;Behavioral;biobehavior;Boston;Characteristics;Collaborations;Communities;Community Health;community setting;Data;Development;Disease Outbreaks;Drug user;Education;efficacy testing;Enrollment;Epidemiologist;Equation;Evaluation;experience;Gender;Geographic Locations;Hair;Health;Heterogeneity;Heterosexuals;high risk population;HIV;HIV Infections;HIV risk;improved;Incidence;informant;Injecting drug user;injection drug use;Injections;interest;Intervention;intervention effect;Interview;Knowledge;Letters;Location;Maintenance;marginalized population;Massachusetts;Mediator;Medical;men who have sex with men;Modeling;Monitor;Motivation;motivational enhancement therapy;multiple drug use;National Institute of Drug Abuse;Needle-Exchange Programs;opioid injection;opioid use;Oral;Participant;Pharmaceutical Preparations;Pharmacy facility;Population;Populations at Risk;Positioning Attribute;pre-exposure prophylaxis;prevent;preventive intervention;primary outcome;Problem Solving;Provider;Public Health;Qualitative Research;Randomized;Randomized, Controlled Trials;Recommendation;Records;recruit;Research;Research Design;Risk;Risk Behaviors;risk perception;Sampling;Scientist;secondary outcome;Self Efficacy;Sexual Partners;Site;skills;social;standard of care;Sterility;Stimulant;stimulant use;substance use;substance user;Suggestion;Syringes;Tenofovir;Testing;theories;Training;transmission process;Treatment Efficacy;United States;United States Preventative Services Task Force;uptake;Woman;Work

PROJECT_TITLE: Efficacy of a community-based PrEP uptake intervention for people who inject drugs in the US Northeast


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Genetics;Hematology;Human Genome;Orphan Drug;Precision Medicine;Rare Diseases

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE The major goal of the Mayo Clinic Center for Clinical Proteomics is to apply the most advanced proteomics and genomics technologies for characterizing multiple myeloma cell lines and patient-derived cells to identify markers of immunomodulatory drug resistance and to validate them using clinical trial samples. Our highly innovative and interdisciplinary team with expertise in multiple myeloma research and treatment, proteomics and genomics technologies/instrumentation, targeted assay development, clinical chemistry and bioinformatics will maximize the chances of successful clinical translation of protein markers of drug resistance in multiple myeloma.

PI_NAMEs: FONSECA, RAFAEL ;PANDEY, AKHILESH  (contact)

PROGRAM_OFFICER_NAME: HILTKE, TARA

PROJECT_TERMS: anti-cancer;arm;assay development;Basic Science;Bioinformatics;Biological Assay;Biological Markers;biomarker identification;candidate validation;Cell Line;Cells;Clinic;clinical assay development;clinical center;Clinical Chemistry;Clinical Research;clinical translation;Clinical Trials;comparative genomic hybridization;Complex;Conduct Clinical Trials;Cost Analysis;Cytogenetics;Cytometry;Data;Data Analyses;data handling;Databases;Dedications;design;Detection;detection sensitivity;Development;Diagnosis;Discipline;Disease;Down-Regulation;Drug resistance;Ensure;exome sequencing;experience;experimental study;forging;Gene Expression;Generations;Genetic Engineering;genetically modified cells;Genome;genomic aberrations;Genomics;Goals;Human;Human Resources;humanized mouse;Imides;Immune;immune modulating agents;Immune response;immunoregulation;improved;Infrastructure;innovation;instrument;instrumentation;IRF4 gene;lenalidomide;Maps;mass spectrometer;Mass Spectrum Analysis;Mediating;Modeling;molecular marker;Molecular Target;mouse model;multidisciplinary;Multiple Myeloma;multiple omics;Mutation;novel;novel therapeutics;Partner in relationship;Pathway interactions;Patients;Peptides;Pharmaceutical Preparations;phosphoproteomics;Phosphorylation;Phosphotyrosine;Physicians;pomalidomide;Post-Translational Protein Processing;pre-clinical;pre-clinical research;predicting response;Protein Analysis;protein biomarkers;protein expression;Proteins;proteogenomics;Proteome;Proteomics;Publications;Quality Control;reference genome;Regimen;Relapse;Research;Research Personnel;Resistance;Resolution;response;Sampling;Scientist;success;targeted sequencing;Technology;technology platform;Thalidomide;transcription factor;transcriptome;transcriptome sequencing;transcriptomics;treatment response;tumor;ubiquitin-protein ligase;Universities;Visualization


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities

PI_NAMEs: RAMALINGAM, SURESH S (contact)

PROJECT_TERMS: Acceleration;Achievement;Address;administrative database;anti-cancer research;Award;Back;Cancer Center Support Grant;cancer education;cancer immunotherapy;career;career development;Caring;Catchment Area;Center for Translational Science Activities;Clinical Investigator;Clinical Investigator Award;Clinical Oncology;Clinical Research;Clinical Trials;Communication;Communities;County;Custom;Data;Development;Disparity;Education;Ensure;First Independent Research Support and Transition Awards;Fostering;Funding;Goals;Grant;Growth;Health Disparities Research;innovation;Institution;Investigation;Investments;Journals;Leadership;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of thorax;Malignant Neoplasms;member;mid-career faculty;Mission;Monitor;multidisciplinary;Mutate;Nature;neoplasm registry;novel;oral HPV-positive head and neck cancers;Outcome;Patients;Peer Review;Performance;Philanthropic Fund;Pilot Projects;Process;Program Effectiveness;Program Evaluation;programmed cell death protein 1;programs;prostate cancer risk;Publications;Reporting;Research;research and development;Research Personnel;Research Project Grants;Research Support;Resource Sharing;Resources;Risk Factors;Rural;Science;Seminal;Standardization;STK11 gene;Strategic Planning;Study Section;Surveys;targeted agent;targeted treatment;Technology;technology platform;Therapeutic Agents;therapy development;Time;Tobacco-Related Carcinoma;Training and Education;Translating;United States National Institutes of Health;Universities

PROJECT_TITLE: Developmental Funds


ORG_CITY: Chicago

ORG_NAME: NORTHWESTERN UNIVERSITY

ORG_STATE: IL

PHR: Project Narrative The overarching goal of this proposal is to train pre-doctoral graduate students of exceptional promise for scientific research careers in molecular biophysics, which is an area that embraces principles and concepts from diverse fields in the natural sciences including biology, physics, chemistry, and mathematics. A rigorous quantitative foundation in molecular biophysics is vital for developing a deep understanding of the biology underlying a broad swath of public health issues, as this knowledge is key not only to the development of effective therapeutic strategies for mitigating diseases but also for the development of new biological tools and technologies. The training program envisioned in this proposal will thus address an urgent and critical need for highly-qualified research personnel in an area of vital importance to public health while ensuring the country's preeminence in biomedical research.

PI_NAMEs: PINKETT, HEATHER WENDY (contact)

PROGRAM_OFFICER_NAME: STAMM, JOYCE CHIN-CHIN NG

PROJECT_TITLE: Molecular Biophysics Training Program at Northwestern University


NIH_SPENDING_CATS: Cancer;Genetics

PHR: PROJECT NARRATIVE: The efficient repair of DNA damage requires a carefully orchestrated cascade of signaling events in the chromatin flanking the damage site in order to recruit the appropriate repair proteins. In this project we aim to characterize the role of EHMT2, a protein methyl transferase that has important roles in chromatin regulation, in the DNA repair signaling pathway. If successful, this study could lead to the rational development of EHMT2 inhibitors to target the DNA repair pathway in human cancers.

PI_NAMEs: GANESAN, SHRIDAR  (contact)

PROJECT_TERMS: Acetylation;Address;Affect;Binding;BMI1 gene;BRCA1 gene;BRCA2 gene;Cell Survival;Cells;Cellular biology;Chromatin;chromatin modification;Chromatin Remodeling Factor;Clinical;clinically relevant;Computational Biology;Defect;Development;DNA;DNA Damage;DNA Repair;DNA Repair Pathway;drug development;Drug Targeting;Engineering;Event;gene repression;Gene Silencing;Genetic Transcription;genome editing;genomic locus;histone methylation;histone modification;Histones;Human;Impairment;inhibitor;innovation;insight;knock-down;Malignant Neoplasms;Mediating;member;Methods;Methyltransferase;Modification;Molecular Biology;Mus;mutant;Mutation;p53-binding protein 1;PALB2 gene;Pathway interactions;Phenotype;Phosphorylation;Play;Post-Translational Protein Processing;Proteins;recruit;Regulation;Repair Complex;repaired;response;Role;Serine;Signal Pathway;Signal Transduction;Site;small molecule;small molecule inhibitor;synthetic lethal interaction;System;targeted treatment;Therapeutically Targetable;Transcriptional Regulation;Transferase;treatment response;tumorigenesis;Ubiquitination

PROJECT_TITLE: Project 3: Chromatin modifiers of BRCA-related DNA repair Pathways


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Disability Research;Neurosciences;Pediatric;Prevention

ORG_CITY: EAST LANSING

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: MICHIGAN STATE UNIVERSITY

ORG_STATE: MI

PHR: Project Narrative Stuttering affects 70 million people worldwide and has lifelong adverse consequences. This project examines the mechanisms underlying the development of stuttering in individual preschool children. We use a comprehensive, multilevel approach to map the development of neurological, behavioral, and experiential factors to learn how these factors unfold over time and contribute to different stuttering outcomes—persistence or recovery. This proposal is consistent with the mission of NIH in that scientific discoveries from our research will improve understanding of how stuttering develops in individual children, leading to advances in diagnostic and intervention approaches.

PI_NAMEs: WALSH, BRIDGET M (contact)

PROGRAM_OFFICER_NAME: KOPF, LISA MARIE

PROJECT_TERMS: Acceleration;Achievement;Address;Adopted;Adult;adverse outcome;Affect;Age;Anxiety;Arousal;Assessment tool;Attitude;Awareness;Behavioral;Biological Markers;Brain;Brain imaging;Brain region;Child;Childhood;Chronic;Clinical;Cognitive;combinatorial;Communication;Communication difficulty;Coupling;Cross-Sectional Studies;Data;Development;Diagnostic;Disease;Emotional;emotional factor;Emotions;Equation;Etiology;experience;functional near infrared spectroscopy;Goals;Guidelines;hemodynamics;imaging modality;imprint;improved;Individual;Influentials;insight;Intervention;Lead;Learning;Life Experience;Light;Linguistics;Link;longitudinal design;Longitudinal Studies;Maps;Mission;Modeling;neural;neuroimaging;Neurologic;neurophysiology;novel;novel therapeutic intervention;Nursery Schools;Outcome;Output;Pathway interactions;Performance;Persons;Physiological;Preschool Child;Prevention;Prevention strategy;Production;psychosocial development;Quality of life;Recovery;Research;Resources;response;Risk;Risk Factors;Risk Marker;Role;School-Age Population;Scientist;Severities;skills;Speech;Speech-Language Pathology;Stuttering;Sympathetic Nervous System;Techniques;Testing;Time;Translating;treatment strategy;United States National Institutes of Health;Variant;Vocation

PROJECT_TITLE: Developmental Trajectories to Stuttering Persistence and Recovery

STUDY_SECTION: MFSR

STUDY_SECTION_NAME: Motor Function, Speech and Rehabilitation Study Section[MFSR]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Climate-Related Exposures and Conditions;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurodegenerative;Palliative Care;Prevention;Rural Health;Social Determinants of Health

ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: PROJECT NARRATIVE There is a large and increasing number of older adults with dementia who are living at home with supports from family and other caregivers, and these individuals and caregivers are extremely vulnerable in disaster situations. This research will test the efficacy of a Disaster PrepWise (DPW) intervention delivered through an existing public health disaster management infrastructure, Medical Reserve Corp, on enhancing resilience and reducing stress among caregivers by providing individualized support to develop personalized disaster preparedness plans and emergency support networks. The number of federally declared disasters continues to increase in the US, thus, understanding the efficacy of this program and optimal implementation strategies can lead to promising public health approaches to address disaster-related vulnerability among persons with dementia and their families.

PI_NAMEs: ASHIDA, SATO  (contact)

PROGRAM_OFFICER_NAME: RIDDLE, MELISSA

PROJECT_TERMS: Address;Aging;Alzheimer's disease related dementia;Area;arm;Behavior;care giving burden;Caregiver support;Caregivers;caregiving;Caring;community engagement process;community partners;Control Groups;coping;COVID-19 pandemic;Data;Dementia;Dementia caregivers;Disasters;Distress;efficacy evaluation;efficacy testing;Elements;emergency preparedness;Emergency Situation;Ensure;experience;extreme weather;Family;family support;Feeling;Floods;Foundations;Fright;Future;Geography;Goals;group intervention;hazard;Health;Health Personnel;Home;Household;hybrid type 2 design;implementation evaluation;implementation strategy;improved;Individual;informal support;Infrastructure;innovation;Intervention;intervention participants;intervention program;Iowa;Knowledge;Life;Mediating;Medical;medical supply;Mental Health;Modeling;Modernization;older adult;Outcome;pandemic disease;Participant;Patients;Perception;Personal Satisfaction;Persons;Pharmaceutical Preparations;physical conditioning;Pilot Projects;pilot test;Practical Robust Implementation and Sustainability Model;pragmatic trial;Printing;Process;programs;promote resilience;Public Health;Randomized;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Readiness;Reporting;Research;resilience;Resources;response;Rural;rural area;rural setting;SARS-CoV-2 infection;Security;Self Efficacy;service providers;skills;Social isolation;Social Network;social stigma;Social support;Stress;stress reduction;support network;Surveys;System;Testing;Tornadoes;Training;United States National Institutes of Health;usability;volunteer;Vulnerable Populations;Work

PROJECT_TITLE: Emergency preparedness and support of caregivers of persons with dementia: The Disaster PrepWise study

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-K(90)]


NIH_SPENDING_CATS: Cancer

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

PI_NAMEs: LESINSKI, GREGORY B. (contact)

PROJECT_TERMS: Applications Grants;Awareness;Cancer Center Support Grant;Capital;Cell Therapy;cost effective;Data;data sharing networks;Decision Making;Education;Equipment;Event;Extramural Activities;Fostering;Future;Goals;Grant;Growth;Human Resources;Immune;improved;Infrastructure;Institution;Investments;Journals;Malignant Neoplasms;member;Modeling;Monitor;Needs Assessment;operation;Peer Review;Peer Review Grants;prevent;programs;Publications;Reporting;Research;Research Personnel;Research Priority;Resource Sharing;Science;Services;square foot;stem;Strategic Planning;Strategic vision;Structure;Technology;therapy development;Time;Universities

PROJECT_TITLE: Shared Resource Management


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: SEATTLE

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative The bacterium Salmonella represents a major threat to human health. We have discovered a regulatory mechanism that links the ability of Salmonella to cause disease with its ability to resist the actions of antibiotics. In this project we will analyze this mechanism and determine how it can be exploited to treat Salmonella infections.

PI_NAMEs: FANG, FERRIC C (contact)

PROGRAM_OFFICER_NAME: ALEXANDER, WILLIAM A

PROJECT_TERMS: Affinity;Antibiotic Resistance;Antibiotics;Antimicrobial Resistance;Bacteria;Bacterial Infections;bacterial metabolism;Binding Sites;carboxylate;comparative;Data;Disease;Drug Efflux;Drug resistance;efflux pump;enteric pathogen;Evolution;Family;Genes;Genetic;Genetic Transcription;Health;Human;In Vitro;in vivo;insight;Ligands;Link;Metabolic;Metabolism;Metabolite Interaction;metabolomics;Methods;Mutation;new therapeutic target;Operon;Phenocopy;Phenotype;Prevention;Proteins;Regulation;Regulon;Repression;response;Salmonella;Salmonella infections;Salmonella typhimurium;Signal Transduction;transcription factor;Transcription Repressor;Virulence;virulence gene

PROJECT_TITLE: Coordinate Regulation of Salmonella Virulence and Antimicrobial Resistance by MarR Transcription Factors

STUDY_SECTION: BACP

STUDY_SECTION_NAME: Bacterial Pathogenesis Study Section[BACP]


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Genetics;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

PHR: Health Relevance: Recent studies have suggested that a large portion of the medulloblastomas may have a signature of homologous recombination defects (HRD) resembling the BRCAness tumors. However, the HRD has not been fully exploited for the targeted treatment of medulloblastomas. Our study will establish new genomic signature of HRD and validate new therapeutic approaches to target medulloblastomas with HRD.

PROJECT_TERMS: Aftercare;Binding;Brain Neoplasms;brca gene;BRCA mutations;BRCA1 gene;BRCA2 gene;C-terminal;cancer predisposition;CDKN1A gene;Cells;Cessation of life;Characteristics;chemotherapy;Chromosomal Breaks;Chromosomes;Code;Complex;conditional knockout;Data;Defect;Development;DNA Binding Domain;DNA biosynthesis;DNA Damage;DNA Repair;DNA Repair Gene;DNA replication fork;DNA strand break;Down-Regulation;efficacy validation;Embryo;Epigenetic Process;Exhibits;Functional disorder;gene network;Genes;Genome;genome-wide;genomic biomarker;genomic signature;Genomics;Germ Lines;Germ-Line Mutation;Glial Fibrillary Acidic Protein;Goals;Health;high risk;homologous recombination;Human;Hypersensitivity;In Vitro;Individual;inhibitor;irinotecan;knock-down;Malignant Childhood Neoplasm;Malignant Neoplasms;Mammary gland;Mediating;Medulloblastoma;medulloblastoma cell line;Modeling;Molecular;Mus;Mutation;neoplastic cell;novel therapeutic intervention;novel therapeutics;Organ;Ovary;PALB2 gene;Pancreas;Patients;Pediatric Neoplasm;Pharmaceutical Preparations;Poly(ADP-ribose) Polymerase Inhibitor;preclinical study;Progression-Free Survivals;promoter;Prostate;Proteins;Radiation;recruit;Recurrence;Recurrent tumor;replication stress;response;Risk;Signal Transduction;Site;stem;stem cells;Structure;success;targeted treatment;Testing;therapeutic development;Time;Topoisomerase;Treatment Protocols;treatment response;tumor;tumorigenesis;Ustilago

PROJECT_TITLE: Project 4: The BRCA Network in Medulloblastoma Responses to Replication Stress


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Genetics;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza;Rare Diseases

ORG_CITY: BATON ROUGE

ORG_NAME: SOUTHERN UNIV A&M COL BATON ROUGE

ORG_STATE: LA

PHR: Role of Legionella pneumophila Lvh TIVSS in virulence Legionnaires’ disease a form of potentially fatal pneumonia caused by Legionella infection, afflicts thousands each year in the United States. This proposal will identify lvh type IV secretion system virulent through transcriptome analyses and investigation of program cell death of infected macrophages that will improve our understanding of Legionella pathogenesis. Identification of these processes essential to virulence will aid in the development of improved therapeutic options to treat Legionnaires’ disease.

PI_NAMEs: DUBYTSKA, LIDIYA  (contact)

PROGRAM_OFFICER_NAME: BERNAL, FEDERICO

PROJECT_TERMS: Affect;Amoeba genus;Anaplasma phagocytophilum;Antibodies;ANXA5 gene;Apoptosis;Apoptotic;atypical pneumonia;Bacteria;Biological Assay;CASP3 gene;CASP7 gene;CASP8 gene;Caspase;Cell Death;Cells;Clinical;combat;Cyst;cytokine;cytotoxicity;Data;design;Development;Disease;disorder control;Environment;Future;Gene Cluster;Gene Expression;Gene Expression Regulation;gene function;Genes;Genetic;Genome;Goals;Health;Host Defense;Human;IL18 gene;Immune response;Immune system;Immunity;immunoregulation;improved;Incubated;Individual;Infection;Innate Immune Response;Interleukin-1 beta;interleukin-1beta-converting enzyme inhibitor;Investigation;Lactate Dehydrogenase;Legionella;Legionella pneumophila;Legionnaires' Disease;Literature;Macrophage;Measures;Membrane;Messenger RNA;microbial;Microbial Biofilms;Mitochondria;Molecular;mutant;Organelles;Outcome;pathogen;Pathogenesis;pathogenic bacteria;Pathway interactions;Phagosomes;Play;Plumbing;Pneumonia;pro-apoptotic protein;Process;programs;Promega;Proteins;Proteome;Reporting;Resistance;response;restoration;Role;Signal Transduction;Site;System;Testing;Therapeutic;Therapeutic Intervention;Time;trafficking;transcriptome;transcriptome sequencing;Type IV Secretion System Pathway;United States;Vaccines;Virulence;Virulence Factors;virulence gene;Virulent;Water;Water Purification;Western Blotting;Work