NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research;Social Determinants of Health

PHR: PROJECT NARRATIVE  This proposal seeks continuation of the Health and Retirement Study (HRS) core data collection for three more waves and the Harmonized Cognitive Assessment Protocol (HCAP) for one more wave, including the introduction of a new younger cohort in 2028 to refresh the HRS sample following the steady state sampling design. It will build the repository of biosamples, expand data linkages of the ADRD exposome, maintain the expanded representation of minorities, and further expand data access to maintain the studies as the premier source of data on public health of the older population, with a special focus on ADRD. Cost savings will be achieved through innovative methods.

PI_NAMEs: LANGA, KENNETH M;WEIR, DAVID R. (contact)

PROGRAM_OFFICER_NAME: PHILLIPS, JOHN

PROJECT_TERMS: Address;African American;Age;aged;Aging;aging biomarker;aging population;aging process;Agreement;Alzheimer's disease related dementia;Amyloid;Antibodies;Bibliography;Biological Assay;Biological Markers;Biological Specimen Banks;Birth;Black race;Blood;Blood specimen;Cessation of life;Charge;Clinical;cognitive testing;cohort;Collaborations;Collection;Communities;Consent;Consumption;cost;cost effective;Cost Savings;COVID-19 pandemic;Creativeness;Cryopreserved Cell;Data;data access;Data Collection;Data Linkages;data quality;data resource;Data Set;dementia risk;design;Development;Diagnostic;distributed data;DNA;DNA Methylation;Documentation;economic outcome;Education;Enrollment;Environmental Exposure;ethnic disparity;Evaluation;Exhibits;Family health status;follow-up;genome-wide;Genotype;Geographic Locations;Grant;hallmarks of aging;Health;Health and Retirement Study;Heavy Metals;Hispanic;Household;immune function;Impaired cognition;improved;indexing;Infection;inflammatory marker;Information Systems;innovation;International;Internet;Interview;Interviewer;Investigator-Initiated Research;Investments;Journals;Latino;life history;Link;long term consequences of COVID-19;longitudinal design;Longitudinal Studies;Measurement;Measures;Medicaid;Medicare;member;Metabolic;Methods;Minority;Monitor;multidisciplinary;Nerve Degeneration;novel strategies;Occupational;Older Population;Organ;Participant;participant enrollment;Peer Review;Pensions;Periodicity;Personal Satisfaction;Persons;Physical Performance;Policies;Population;Prevention;programs;Property;Protocols documentation;Public Health;Publications;racial disparity;Recording of previous events;Records;recruit;repository;Research;Research Design;Research Personnel;Research Support;resilience;Resources;Respondent;response;Rotation;Saliva;Sampling;Sampling Studies;SARS-CoV-2 exposure;SARS-CoV-2 infection;Schedule;Scientist;Secure;Services;Social Security;Source;Structure;support network;Surveys;symposium;tau Proteins;Telephone;Time;Training Support;trend;U-Series Cooperative Agreements;United States Centers for Medicare and Medicaid Services;United States Social Security Administration;Update;Venous;Veterans Health Administration;virtual;web site

PROJECT_TITLE: Health and Retirement Study: Yrs 35-40

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-4 (J1)]


ADMINISTERING_IC: AR

ARRA_FUNDED: N

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Arthritis;Clinical Research;Pediatric;Physical Activity;Women's Health Research

ORG_CITY: BOSTON

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PHYSICAL MEDICINE & REHAB

ORG_FIPS: US

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

ORG_STATE: MA

PHR: Project Narrative Early and regular participation in certain sports (such as soccer, basketball, and ice hockey) during youth seems to alter hip shape in boys in ways that contribute to pain and arthritis later in life; however, it is unclear if participation in sports has a similar effect on girls’ hips. This proposal seeks to investigate how regular participation in sport relates to hip structure and function in girls. The knowledge gained from this study may lead to programs to promote hip health in young active females.

PI_NAMEs: LEWIS, CARA L (contact)

PROGRAM_OFFICER_NAME: WASHABAUGH, CHARLES H

PROJECT_TERMS: 12 year old;17 year old;3-Dimensional;Accelerometer;acetabulum;Acute;Adolescence;Adult women;Affect;Age;Arthritis;Articular Range of Motion;balance testing;Bilateral;bone;Bone Growth;boys;Clinical;clinical practice;Clinical Research;critical period;Data;Degenerative polyarthritis;design;Development;Diagnosis;Disparity;Dysplasia;Economics;Evaluation;Female;Femur;Future;future implementation;girls;Growth;Health;Hip Osteoarthritis;Hip Pain;Hip region structure;Hockey;Ice Hockey;improved;Individual;information gathering;Injury;Intervention;Investigation;Knowledge;Laboratories;Laws;Life;life span;Link;Longitudinal Studies;Lower Extremity;Magnetic Resonance Imaging;male;Manufactured basketball;Measures;Morphology;Motion;Movement;neuromuscular training;Observational Study;Pain;Pathology;Pattern;Pelvis;Performance;Physical activity;Play;Prevalence;programs;Puberty;Recommendation;recruit;Research;Risk;Risk Reduction;secondary analysis;sex;Shapes;skeletal;Soccer;Sports;Structure;Surveys;Symptoms;Syndrome;Time;Translating;Variant;Walking;Woman;Women's prevalence;Work;young adult;Youth

PROJECT_TITLE: Hip structure and function in young female athletes

STUDY_SECTION: AMSC

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Clinical Trials Study Section [AMSC]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Kidney Disease

ORG_CITY: NEW YORK

ORG_DEPT: SURGERY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: PROJECT NARRATIVE The Kidney Disease Aging Research Collaborative (KDARC) will address a fundamental challenge in nephrology by establishing sustainable research infrastructure that will facilitate collaborations, clarify research priorities, minimize barriers to data access, and enhance investigator development. Ultimately, this infrastructure will enable high-impact research on the science of aging in nephrology and improve the health and well-being of 22.4 million older adults who are living with kidney disease in the US.

PI_NAMEs: HALL, RASHEEDA K;MCADAMS DEMARCO, MARA A. (contact)

PROGRAM_OFFICER_NAME: SERRA, MONICA CHRISTINE

PROJECT_TERMS: access disparities;Address;Adopted;Adult;Age;Age disparity;Aging;aging related disease;Applications Grants;Award;career;career development;Caring;Chronic Kidney Failure;clinical practice;Clinical Research;cohort;Collaborations;Communities;community engagement;Consensus;Consultations;Data;data access;Data Collection;data harmonization;Data Set;Dedications;Development;disease registry;Elderly;Eligibility Determination;End stage renal failure;Engineering;Epidemiologist;Evaluation;experience;Faculty;faculty mentor;faculty support;frailty;Funding;Future;Health;human old age (65+);Impaired cognition;improved;Infrastructure;inter-institutional;Interdisciplinary Study;Investments;Kidney;Kidney Diseases;Kidney Transplantation;Knowledge;Manuscripts;Measurement;Measures;Medicare;Medicine;member;Mentors;Methods;Monitor;Nephrology;novel;older adult;older patient;organizational structure;Palliative Care;Participant;patient engagement;Patients;Personal Satisfaction;Phase;Physical Function;Pilot Projects;Preparation;Procedures;programs;prospective;Publications;Publishing;Registries;Research;Research Infrastructure;Research Personnel;Research Priority;Resources;Sampling;Science;Services;skills;Study Section;symposium;Syndrome;tool;Training;transplant registry;United States National Academy of Sciences;Variant;Workforce Development

PROJECT_TITLE: Kidney Disease Aging Research Collaborative (KDARC) Research Infrastructure to Advance the Science of Geriatric Nephrology

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-2 (J1)]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Breast Cancer;Cancer;Genetics;Immunotherapy;Prevention;Women's Health Research

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative This research focuses on an innovative concept that immune cells can be leveraged for breast cancer immunoprevention in BRCA mutation careers. This proposal aims to determine the underlying mechanism that regulates the recruitment of immune cells into BRCA mutant breast glands and devise novel strategies to harness these immune cells to achieve effective cancer prevention in high-risk patients. The outcomes of this research will lead to the development of novel therapies for preventing and treating breast cancer using patients’ immune system.

PI_NAMEs: DEMEHRI, SHADMEHR  (contact)

PROGRAM_OFFICER_NAME: MOHAMMED, ALTAF

PROJECT_TERMS: Address;Age;Alleles;Animal Model;anti-tumor immune response;Antigens;antitumor effect;BRCA mutations;BRCA1 gene;BRCA2 gene;BRCA2 Mutation;Breast;Breast Cancer Cell;Breast Cancer Prevention;Breast Cancer Risk Factor;Breast Epithelial Cells;cancer immunotherapy;cancer infiltrating T cells;cancer prevention;cancer therapy;career;CD4 Positive T Lymphocytes;CD8B1 gene;Cells;Cellular Stress;Characteristics;cohort;cytokine;Data;Defect;Development;Disease;Disseminated Malignant Neoplasm;DNA Damage;efficacy evaluation;Environment;Epithelial Cells;Epithelium;experience;Foundations;Gene Mutation;Germ-Line Mutation;Gland;Goals;Heterogeneity;high risk;high risk population;Histologic;human tissue;Immune;immune activation;immune cell infiltrate;immune modulating agents;Immune response;Immune signaling;Immune system;Immunity;immunogenic;Immunologic Factors;Immunologic Surveillance;Immunoprevention;Immunotherapeutic agent;Immunotherapy;Infection;Infiltration;Inflammatory;innovation;Interferon Type I;Intervention;Lesion;Ligands;Malignant - descriptor;Malignant Breast Neoplasm;Malignant Neoplasms;mouse model;Mus;mutant;Mutation;mutation carrier;Nature;Neoplasm Metastasis;novel;novel strategies;novel therapeutics;Oncogenic;Outcome;Outcomes Research;Pathway interactions;Patients;Play;premalignant;prevent;Property;recruit;Recurrence;Research;response;Risk;Role;Signal Transduction;Stress;T cell infiltration;T cell response;T-Lymphocyte;Testing;Tissues;tumor;Tumor Immunity;tumor progression;Vaccines

PROJECT_TITLE: Immunosurveillance of breast glands with oncogenic germline mutations

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 RTRB-U (J1)]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: SEATTLE

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: NARRATIVE A human body is composed of trillions of cells. Within the past decade, single cell biology has exploded, and researchers now routinely characterize the molecular contents of individual cells obtained from human and animal tissues. However, the most widely used methods remain limited in critical ways. The open-source technologies and protocols developed and proactively disseminated by this project will advance the field's ability to scalably measure and record biology at single cell resolution, and especially so in the context of genetic and chemical perturbations of key model systems.

PI_NAMEs: SHENDURE, JAY ASHOK (contact);TRAPNELL, BRUCE COLSTON

PROGRAM_OFFICER_NAME: CHADWICK, LISA

PROJECT_TERMS: Acceleration;Adoption;animal tissue;Animals;Area;ATAC-seq;Atlases;Award;Bar Codes;base editing;Benchmarking;Biological Models;Biology;Biomedical Research;Cell Culture Techniques;cell fixing;Cell Lineage;Cell model;Cell Nucleus;Cells;Cellular biology;Chemicals;Chromatin;Chromosomes;Clustered Regularly Interspaced Short Palindromic Repeats;combinatorial;Communities;Complex;Computer software;cost effective;Data;Data Set;Development;developmental genetics;disease model;DNA;Elements;Embryo;Embryoid bodies;experimental study;Explosion;Failure;fly;Foundations;Gene Expression;Gene Expression Profiling;Gene Expression Regulation;Generations;Genes;Genetic;Genetic Models;Genome;genome-wide;Genomics;Genotype;Goals;Guide RNA;Human Biology;Human body;human model;Human Resources;human tissue;improved;In Vitro;in vivo;indexing;Individual;integration site;interest;Light;Location;Measures;method development;Methods;Microscopy;Mission;Modality;Modeling;Molecular;Molecular Conformation;Molecular Profiling;Molecular Target;multimodality;Mus;mutant;Mutation;novel;Nuclear;Nucleic Acids;Oligonucleotides;open source;Optics;Organogenesis;Organoids;Performance;Phenotype;Physiological;pleiotropism;portability;prime editing;Protocols documentation;Recording of previous events;Recovery;Regulatory Element;Reporting;Research Personnel;Resolution;reverse genetics;Sampling;Standardization;Structure;success;System;Technology;Tissues;transcriptome sequencing;transcriptomic profiling;transcriptomics;translational model;Vision;Whole Organism;Work;Zebrafish

PROJECT_TITLE: Versatile, exponentially scalable methods for single cell molecular profiling

STUDY_SECTION: GCAT

STUDY_SECTION_NAME: Genomics, Computational Biology and Technology Study Section[GCAT]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Digestive Diseases;Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: CINCINNATI

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF CINCINNATI

ORG_STATE: OH

PHR: PROJECT NARRATIVE Understanding diseases, including diabetes, pancreatitis, and cancers, requires a comprehensive knowledge of how cells and tissues normally respond to stress to maintain stability. Important aspects of this are controlled by the organization and structure of the DNA within cells. We will study this biology and the important downstream (and potentially pathogenic) consequences when this normal regulation is lost.

PI_NAMEs: WASYLISHEN, AMANDA RIETTA (contact)

PROGRAM_OFFICER_NAME: ANDERSEN, DANA K

PROJECT_TERMS: Affect;Alleles;ATRX gene;Binding;Biology;Cell Differentiation process;Cells;Chromatin;Complex;Coupled;Data;DAXX gene;Deposition;derepression;Diabetes Mellitus;Disease;DNA Structure;Embryo;embryo tissue;Endogenous Retroviruses;Epigenetic Process;epigenetic regulation;epigenome;epigenomic profiling;epigenomics;Epithelial Cells;Equilibrium;Frequencies;Gene Expression;Genes;Genetic;Genetic Models;Genetic Transcription;Genome;Genomics;Germ Lines;Goals;Hematopoietic;Hematopoietic stem cells;Heterochromatin;Histone H3;Histones;Homeostasis;Human;human embryonic stem cell;Human Genome;Impairment;In Vitro;in vivo;in vivo regeneration;Individual;induced pluripotent stem cell;infancy;Injury;injury and repair;innovation;insight;Islet Cell Tumor;Knowledge;Lead;Lesion;Link;loss of function mutation;Maintenance;Malignant Neoplasms;Mediating;Mediator;Metaplasia;Modeling;Molecular;Molecular Chaperones;mouse model;Mus;mutant;Mutation;Normal tissue morphology;Outcome;Pancreas;Pancreatic Injury;Pancreatitis;Pathogenicity;Pathologic;Phenotype;Physiological;postnatal;programs;protein protein interaction;Recurrence;Regenerative response;Regulation;Repression;Research;Role;Somatic Mutation;Stress;Structure;Testing;transcriptome;transcriptomic profiling;transcriptomics;Tumor Suppression;tumorigenesis;Variant;Work

PROJECT_TITLE: Histone chaperones and cell state regulation

STUDY_SECTION: MG

STUDY_SECTION_NAME: Molecular Genetics Study Section[MG]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Nanotechnology

ORG_CITY: FRESNO

ORG_DEPT: CHEMISTRY

ORG_NAME: CALIFORNIA STATE UNIVERSITY FRESNO

ORG_STATE: CA

PHR: PROJECT NARRATIVE The Nicoya Alto is an advanced instrument capable of measuring protein interactions in real-time using a powerful technique called surface plasmon resonance. This instrument will enable researchers and students at Fresno State to study proteins for developing new cancer drugs, anti-bacterials, and nanomaterials. This new capability will help to train a new generation of scientists combing form the under-represented minorities found in California’s central valley.

PI_NAMEs: BROOKS, CORY  (contact)

PROGRAM_OFFICER_NAME: BECKETT, DOROTHY

PROJECT_TERMS: Affinity;Anti-Bacterial Agents;antibody engineering;Antineoplastic Agents;Binding;Biomedical Research;California;college;drug discovery;Education;Education Projects;Generations;Goals;Infrastructure;innovation;instrument;Interdisciplinary Study;Kinetics;Ligands;Mathematics;Measurement;Measures;Minority-Serving Institution;nanomaterials;next generation;Peptides;Population;protein structure;Proteins;Research;Research Project Grants;Sampling;Science;Students;Surface Plasmon Resonance;Time;Training;undergraduate student;Underrepresented Minority;Underrepresented Populations;university student

PROJECT_TITLE: Surface Plasmon Resonance to Measure Biomolecular Interaction at Fresno State

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CDB-L (30)]


NIH_SPENDING_CATS: Aging;Cardiovascular;Heart Disease;Natural Products;Nutrition;Physical Activity

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

PHR: NARRATIVE Urolithin A is a natural supplement produced by the gut microbiome in about 50% of adults that has been shown to improve mitochondrial function, reduce inflammation, and improve function in multiple tissues in chronic disease models. This proposal builds on our preliminary data demonstrating that supplementation with urolithin A enhances cardiac function in aged mouse hearts. We propose multiscale assays to identify the mechanisms by which urolithin A improves cardiac function and help determine the potential for urolithin A supplementation to enhance healthy aging.

PI_NAMEs: MARCINEK, DAVID J. (contact);REGNIER, MICHAEL

PROGRAM_OFFICER_NAME: GAO, HONGWEI

PROJECT_TERMS: Actins;Adult;Age;age effect;age related;age related changes;aged;Aging;Area;Biological Aging;Biological Assay;Biology;Biology of Aging;biomechanical test;Bolus Infusion;Calcium;Cardiac;cardiac aging;Cardiac Function Study;Cardiac Myocytes;Cardiovascular Diseases;Cardiovascular Physiology;cardiovascular risk factor;Cell Communication;Cells;Chronic Disease;Clinical;clinical risk;Clinical Trials;Data;design;Development;disease model;Echocardiography;EFRAC;Electron Transport;Energy Metabolism;Exercise;exercise intolerance;Exercise Tolerance;experimental study;Fibrosis;Functional disorder;functional improvement;Future;Gene Expression;Gene Expression Profiling;genetic regulatory protein;gut microbiome;healthy aging;Heart;Heart failure;heart function;Histopathology;Hypertrophy;improved;In Situ;in vivo;Inflammation;Inflammatory;innovation;insight;interest;International;Kinetics;Left;Link;Machine Learning;Measures;Mechanics;Metabolic;Metabolism;Mitochondria;mitochondrial dysfunction;Molecular;mouse model;Myocardial dysfunction;Myofibrils;Myosin ATPase;Natural Compound;Natural Supplement;old mice;older adult;oxidation;Oxidation-Reduction;Pathway interactions;Perfusion;Post-Translational Protein Processing;Predisposition;preservation;Production;Protein Analysis;Protein Isoforms;Proteins;public health relevance;Publishing;Quality Control;Reporting;Research;Risk;Risk Factors;Sarcomeres;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Skeletal Muscle;Supplementation;System;Testing;Thick;Tissues;tool;translational approach;Ventricular

PROJECT_TITLE: Mechanisms underlying reversal of cardiac aging by urolithin a treatment

STUDY_SECTION: CMAD

STUDY_SECTION_NAME: Cellular Mechanisms in Aging and Development Study Section[CMAD]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_CITY: PROVIDENCE

ORG_NAME: WOMEN AND INFANTS HOSPITAL-RHODE ISLAND

ORG_STATE: RI

PHR: PROJECT NARRATIVE The finite pool of oocytes with which a female is born, also known as the ovarian reserve, represents the entire reproductive capacity of the female and supports lifelong hormonal function, however an understanding of the mechanisms which underlie its health and quality remain largely unknown. We have identified a novel protein, Ubiquitin C-Terminal Hydrolase L1 (UCHL1), which is highly enriched in mouse and human oocytes from gestation through adulthood, and is required for female fertility in the mouse. This proposal aims to elucidate the tissue-specific roles of UCHL1 in the maintenance of mammalian oocyte quality, test the ability of UCHL1 to influence female endocrine function and reproductive lifespan, and better understand how overall ovarian function depends on oocyte integrity and appropriate protein balance.

PI_NAMEs: GRIVE, KATHRYN J (contact)

PROGRAM_OFFICER_NAME: RAVINDRANATH, NEELAKANTA

PROJECT_TERMS: Ablation;Adult;Affect;Age;Aging;Apoptosis;Cell Communication;cell type;Cells;connexin 37;Connexin 43;Connexins;Data;Defect;Deubiquitinating Enzyme;Development;Endocrine;Equilibrium;Estrous Cycle;Female;female fertility;Female infertility;Fertility;Fertilization;Follicular Fluid;folliculogenesis;Functional disorder;Gap Junctions;Gene Expression;Genes;Germ Cells;Goals;granulosa cell;Health;Hormonal;Human;Infertility;Ischemia;Knock-out;Knockout Mice;life span;Link;Longevity;Maintenance;Measurable;Measures;Modeling;Molecular;Morphology;multicatalytic endopeptidase complex;Mus;mutant;Nerve Degeneration;Neurons;novel;oocyte quality;Oocytes;Ovarian;Ovarian Follicle;ovarian reserve;Ovary;paracrine;Paracrine Communication;Parkinson Disease;Pathway interactions;Peptides;Phenotype;Play;Population;Pregnancy;premature;preservation;programs;Proliferating;protein degradation;Proteins;Proteome;proteostasis;Quality of life;Regulation;Reproduction;reproductive;Reproductive Sciences;response;Risk;Role;Serum;Signal Transduction;single cell sequencing;Somatic Cell;steroid hormone;subfertility;Testing;Tissues;Ubiquitin;ubiquitin C-terminal hydrolase;ubiquitin isopeptidase;Variant;Woman;women's reproductive health;Work;Zona Pellucida;ZP1

PROJECT_TITLE: Requirement for Ubiquitin C-Terminal Hydrolase function in mammalian ovarian health and fertility

STUDY_SECTION: ICER

STUDY_SECTION_NAME: Integrative and Clinical Endocrinology and Reproduction Study Section[ICER]


ADMINISTERING_IC: LM

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Social Determinants of Health

ORG_CITY: MAYWOOD

ORG_NAME: LOYOLA UNIVERSITY CHICAGO

ORG_STATE: IL

PHR: Project Narrative: Over 1.6 million people in the United States identify as transgender or gender diverse (TGD), yet there is inadequate training in TGD-affirming healthcare (i.e., care provision which supports one’s identities, is relevant and competent). Of great concern, gender-based inequities are reflected in the mental and physical health disparities among TGD people compared to cisgender people - including increased rates of suicides, post- traumatic stress disorder, depression, cardiovascular disease and chronic obstructive pulmonary disease. Providing TGD affirming care reduces inequities and improves health outcomes among TGD people and prepares nurses to serve their communities with the utmost dignity and respect based on current research and knowledge.

PI_NAMEs: GARFIELD, LINDSEY ;SQUIRE, DIAN D (contact)

PROGRAM_OFFICER_NAME: BARR, ELIZABETH ANNE

PROJECT_TERMS: Accreditation;Address;Affect;American;American Nurses' Association;Anxiety;Area;Attitude;barrier to care;Cardiovascular Diseases;Caring;Chronic Obstructive Pulmonary Disease;cisgender;Clinical;clinical care;Communities;Community Health;community partners;Continuing Education;Continuity of Patient Care;Country;cultural competence;Data;denial of health care;Discipline of Nursing;Discrimination;Disease;E-learning;Education;Educational Curriculum;Emergency Situation;Empirical Research;experience;Face;Faculty;Focus Groups;Gender;gender affirmation;gender affirming care;gender diverse;gender minority group;Goals;Harm Reduction;Health;health care service utilization;health care settings;health disparity;health equity;Health Professional;Health Promotion;Health Resources;Healthcare;Hour;Human Rights;Hypertension;improved;Individual;Inequity;innovation;Judgment;Knowledge;knowledge integration;Laws;Learning;lens;Lesbian Gay Bisexual Transgender Queer;maltreatment;Measures;member;Mental Depression;Mental Health;Methods;Modeling;National Institute of Nursing Research;novel;Nurse Practitioners;Nurses;Nursing Licensure;Nursing Research;Nursing Schools;Nursing Students;open source;Outcome;Patient advocacy;Patient Care;patient oriented;Patients;Persons;Phase;physical conditioning;Population;population health;Post-Traumatic Stress Disorders;Preparation;Prevention;Professional Organizations;programs;Provider;Qualitative Methods;Quantitative Evaluations;Registered nurse;Reporting;Research;response;Rights;Services;sexual minority group;skills;social health determinants;Strategic Planning;student training;Suicide;suicide rate;System;Training;transgender;Trust;United States;United States Dept. of Health and Human Services;United States National Institutes of Health;web site

PROJECT_TITLE: Trans*forming Care: A 7-Module Program Experience for Nurses to Learn Transgender and Gender Diverse Patient Care through Gamification

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CCHI-P (57)]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Asthma;Basic Behavioral and Social Science;Behavioral and Social Science;Climate-Related Exposures and Conditions;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Pediatric;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: SAN FRANCISCO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative North Richmond, South Fresno, and Southwest Stockton, California are three environmental justice communities with asthma prevalence and asthma-related emergency room visits double that of the rest of the State. Our community-partnered study will increase our understanding of the short-term respiratory health effects of residing near diesel exhaust pollution sources, including frequented truck routes, for Latino/x/e children with asthma while also identifying and co-prioritizing mitigation strategies for adoption and policy change.

PI_NAMEs: THAKUR, NEETA  (contact)

PROGRAM_OFFICER_NAME: O'FALLON, LIAM

PROJECT_TERMS: 17 year old;Acculturation;Address;Adoption;Air;Air Pollutants;Area;Asthma;asthma exacerbation;Automobile Driving;Bronchodilator Agents;California;Carbon Black;Child;Childhood Asthma;Color;Communities;community based participatory research;community engaged research;community engagement process;community organizations;community partners;community partnership;contextual factors;density;Diesel Exhaust;Discrimination;Disparity;Emergency department visit;Enrollment;Environmental Hazards;Environmental Health;environmental justice;experience;Exposure to;fine particles;Generations;Goals;Health;health disparity;Hour;Household;Immigrant;Immigrant community;Individual;Inhalators;Intervention;Latino;Latinx;Laws;Length of Stay;Location;low socioeconomic status;Measures;Medical;meter;Methods;migration;Modeling;Modification;Monitor;Morbidity - disease rate;neighborhood disadvantage;Nonprofit Organizations;Outcome;Persons;Pharmaceutical Preparations;Policies;Pollution;Population;Predisposition;Prevalence;protective factors;Psychosocial Stress;pulmonary function;recruit;Reporting;Research;Research Personnel;Resolution;respiratory health;response;Rest;Risk;Risk Factors;Role;Route;San Francisco;sensor;Social Environment;social stressor;Source;Stress;stressor;Subgroup;Surveys;Symptom Burden;Symptoms;Testing;Time;Universities;Voice;Youth

PROJECT_TITLE: Driving Environmental Justice: Community Monitoring of Diesel Truck Emissions and Impacts onAsthma Morbidity in Immigrant Communities

STUDY_SECTION: CIHB

STUDY_SECTION_NAME: Community Influences on Health Behavior Study Section[CIHB]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: NEW YORK UNIVERSITY

PHR: Project Narrative Obesity is a public health issue that disproportionately affect Black Americans. This proposal will clarify the role that neighborhood and interpersonal discrimination play in adiposity and molecular markers of age-related diseases across three large nationally representative, population-based cohorts. The project will lay the groundwork for future studies to assess the association between discrimination and other age-related outcomes and inform interventions that can be developed to reduce disparities in health.

PI_NAMEs: CUEVAS, ADOLFO  (contact)

PROGRAM_OFFICER_NAME: EVANS, MARY

PROJECT_TERMS: Address;Adipose tissue;Adolescent;Adult;adult obesity;Affect;age related;age-related disease;Asian;Asian Americans;Biological;Biology;Black American;Black Populations;Black race;Body mass index;Body measure procedure;Buffers;Chronic Disease;Chronic Kidney Failure;cohort;Cohort Studies;Coronary heart disease;Data;design;Diabetes Mellitus;Dimensions;Discrimination;Disparity;disparity reduction;Etiology;experience;Exposure to;Foundations;Future;Gene Expression;Genetic Transcription;Goals;Health;Health and Retirement Study;Health Disparities Research;health disparity;healthy weight;High Prevalence;high risk;Hypertension;Individual;Inflammation;Inflammatory;inflammatory marker;Intervention;Knowledge;Leukocytes;Life Cycle Stages;Longitudinal Studies;Measures;Mediating;Mediator;Metabolic;middle age;Molecular;molecular marker;Morbidity - disease rate;mortality;National Longitudinal Survey of Adolescent to Adult Health;Neighborhoods;Not Hispanic or Latino;novel;Obesity;Obesity associated disease;obesity risk;obesity treatment;obesogenic;older adult;Outcome;Pathway interactions;Persons;Physiological;Play;population based;prevent;Prevention;Process;protective factors;Public Health;Race;racial disparity;Research;Research Personnel;response;Risk;Risk Factors;Risk Reduction;Role;Sampling;Skin;Social Environment;social health determinants;social integration;Social outcome;social relationships;stem;Stress;Stroke;Testing;United States;waist circumference;Work

PROJECT_TITLE: Assessing The Impact of Neighborhood and Interpersonal Discrimination on Obesity and Leukocyte Gene Expression

STUDY_SECTION: SEDH

STUDY_SECTION_NAME: Social and Environmental Determinants of Health Study Section[SEDH]


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Hepatitis;Hepatitis - B;Infectious Diseases;Liver Disease;Prevention

PHR: Project Narrative This proposal is founded on an innovative concept that the inhibition of an immune factor called interleukin 33, which plays a critical role in the initiation of chronic inflammation, can suppress cancer development associated with chronic inflammation. The overarching aim of this proposal is to determine the underlying mechanism that regulates the expression of interleukin 33 in the epithelial cells and to identify inhibitors of its expression. The outcomes of this research will lead to the development of a novel strategy for cancer prevention and treatment, which will benefit a large number of individuals affected by chronic inflammation in the United States and around the world.

PROGRAM_OFFICER_NAME: KUO, LILLIAN S

PROJECT_TERMS: Acute;Address;Affect;Allergic inflammation;angiogenesis;Cancer Etiology;cancer prevention;cancer recurrence;cancer risk;cancer therapy;cancer type;cell type;Cells;Cessation of life;Chemical Agents;Chemicals;Chronic;Chronic Hepatitis;chronic inflammatory disease;chronic pancreatitis;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Colitis;Colon;cytokine;Dermatitis;Development;Drug Screening;efficacy evaluation;Environment;Environmental Exposure;Epithelial Cells;Epithelium;Exposure to;FDA approved;Foundations;Goals;Hepatitis;Hepatitis B Virus;Hepatocyte;Human;Immune;Immune response;Immunologic Factors;In Vitro;in vitro Assay;in vivo;Individual;Inflammation;Inflammatory;inhibitor;innovation;Interleukins;knock-down;Knock-out;knockout animal;Knockout Mice;Libraries;Link;Liver;liver inflammation;liver injury;Malignant Neoplasms;Mediating;Mediator;Molecular;mouse model;Mus;Neoplasm Metastasis;novel;novel strategies;novel therapeutic intervention;Nuclear;Outcome;Outcomes Research;overexpression;Pancreas;Pancreatitis;Pathway interactions;Pattern;Play;prevent;Primary carcinoma of the liver cells;receptor;Regulation;Regulatory T-Lymphocyte;Research;Risk Factors;Role;Sampling;Series;Signal Pathway;Skin;small molecule;Testing;Therapeutic Agents;Tissues;transcriptome sequencing;Tropisetron;tumor growth;Tumor Immunity;tumor progression;Tumor Promotion;United States;viral DNA;Virus Diseases;Work

PROJECT_TITLE: Interleukin 33 Regulation for Cancer Prevention in Chronic Inflammation

STUDY_SECTION: CPSS

STUDY_SECTION_NAME: Cancer Prevention Study Section[CPSS]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: IOWA CITY

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: This research has direct relevance to public health by reducing time spent in intervention for speech sound disorders, which are some of the most prevalent communication disorders in young children. Treatment for this impairment is crucial because its impact extends well beyond speech to affect language, literacy, academics, and ultimately, occupational, and socioeconomic outcomes. Further, this research is targeted to maximize treatment efficiency for Spanish-English bilinguals, who represent the predominant population of dual language learners in the US and who are currently severely underrepresented in translational research and underserved in clinical practice.

PI_NAMEs: COMBITHS, PHILIP NICHOL (contact)

PROGRAM_OFFICER_NAME: KOPF, LISA MARIE

PROJECT_TERMS: Academic achievement;access disparities;Address;Affect;Automobile Driving;bilingualism;Biological Models;Child;Clinical;clinical practice;Communication impairment;Complex;Country;Data;design;Disease;disparity reduction;economic outcome;education resources;Educational process of instructing;Employment;Equity;evidence base;Exclusion;Experimental Designs;fly;Foundations;Future;Goals;Growth;health disparity;Healthcare;Household;Impairment;implementation barriers;improved;improved outcome;Individual;Intervention;kindergarten;Language;Learning;Linguistics;literacy;Long-Term Effects;meetings;Modeling;Occupational;Outcome;Participant;peer;Phase I Clinical Trials;phonology;Population;Population Heterogeneity;Procedures;psychosocial;psychosocial wellbeing;Public Health;reading ability;Research;Risk;Role;Schools;skills;socioeconomics;sound;Spanish;Spanish/English;Special Education;Specific qualifier value;Speech;Speech Delay;Speech Development;Speech Sound;Structure;System;Theoretical model;Thinness;Time;Translational Research;Treatment outcome;treatment research;Underserved Population;United States;Work

PROJECT_TITLE: Promoting System-Wide Change for Bilingual Children with Speech Sound Disorder

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences

ORG_CITY: ROCHESTER

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: Project Narrative The proposed research will investigate the role of inhibitory plasticity in the accessory olfactory system, a neural pathway that strongly influences social behaviors in mice. Mice are the predominant mammalian model organism, and evaluating mouse social behaviors is a core component of research into several neuropsychiatric disorders, including autism and schizophrenia. This proposal will improve our understanding of the role of inhibitory plasticity in chemosensory information processing in the brain, and advance knowledge related to the development and maintenance of mammalian social behavior.

PI_NAMEs: MEEKS, JULIAN P (contact)

PROGRAM_OFFICER_NAME: SULLIVAN, SUSAN L

PROJECT_TERMS: Accessory Olfactory Bulbs;Affect;Afferent Neurons;Animal Disease Models;Animals;autism spectrum disorder;Behavior;Behavioral;Behavioral Paradigm;behavioral plasticity;Brain;Calcium;cell type;Cells;Chemicals;Data;Development;Disease;Electrophysiology (science);Environment;Esthesia;Excretory function;experience;Female;Gene Expression Profile;Genetic;Genetic Transcription;Goals;granule cell;House mice;Human;Image;Immediate-Early Genes;improved;in vivo;information processing;Injections;Interneurons;Juxtaglomerular Cell;Knowledge;Label;Learning;Ligands;Maintenance;male;Mammals;Measurement;Measures;Microscopy;mitral cell;model organism;Modeling;Morphology;Mus;neural circuit;Neural Pathways;neuronal patterning;Neurons;neuropsychiatric disorder;novel therapeutics;Olfactory Pathways;optogenetics;Outcome;Output;patch sequencing;Pattern;Peptides;Peripheral;Physiological;Physiology;Procedures;Process;Property;Proteins;Reproductive Physiology;Research;response;Risk;Role;Sampling;Schizophrenia;Sensory;sensory system;Signal Transduction;social;Social Behavior;social engagement;Social Environment;Social Functioning;social influence;Social Interaction;social learning;Specificity;Steroids;Synapses;synaptic inhibition;System;Techniques;Time;Transgenic Mice;Work

PROJECT_TITLE: Inhibitory plasticity and social learning in the accessory olfactory bulb

STUDY_SECTION: NIC

STUDY_SECTION_NAME: Neuroscience of Interoception and Chemosensation Study Section[NIC]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Cerebrovascular;Genetics;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: ANN ARBOR

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE Mutations in the calcium-permeable ion channel TRPV4 (transient receptor potential vanilloid 4) cause forms of hereditary motor-predominant neuronopathy, but the pathological mechanisms of neurodegeneration are unknown. Our work in cellular and animal models of TRPV4-related disease demonstrates that dysregulation of the actin cytoskeleton in neural vascular endothelial cells and resulting blood-neural barrier disruption are likely critical pathological events. Here, we will define the molecular mechanisms by which TRPV4 modulates neural vascular endothelial cell structure and barrier function, which will inform novel therapeutic strategies in neurological disease.

PI_NAMEs: MCCRAY, BRETT ANDREW (contact)

PROGRAM_OFFICER_NAME: NUCKOLLS, GLEN H

PROJECT_TERMS: Actins;Address;Affect;Animal Model;antagonist;behavioral phenotyping;Biochemical;Biological Models;Biosensor;Blood;brain endothelial cell;Brain Stem;Ca(2+)-Calmodulin Dependent Protein Kinase;Calcium;Cations;Cell model;cell type;Cells;Cellular Morphology;Cellular Structures;Cessation of life;Clinical;clinically relevant;Complex;Cytoskeleton;Demyelinating Diseases;Disease;Electrical Resistance;Endothelial Cells;Event;fly;formin-2;Functional disorder;gain of function mutation;Genetic;genetic regulatory protein;hereditary neuropathy;Human;Image;Immunohistochemistry;in vitro Model;in vivo;induced pluripotent stem cell;Inherited;Ion Channel;Ischemia;knock-down;Knock-in;Knock-in Mouse;Knowledge;Measures;Mediating;Mediator;Modeling;Molecular;molecular dynamics;Molecular Target;Monomeric GTP-Binding Proteins;Motor;motor behavior;Motor Neuron Disease;mouse model;mutant;Mutate;Mutation;Nerve;Nerve Degeneration;Nervous System Disorder;neural;neural model;Neurologic;Neuromuscular Diseases;Neuropathy;novel;novel therapeutic intervention;overexpression;Pathologic;Pathway interactions;Patients;Pattern;Permeability;Pharmaceutical Preparations;pharmacologic;Phenotype;phosphoproteomics;Phosphotransferases;protein activation;Proteins;receptor;response;rhoA GTP-Binding Protein;Role;Series;Signal Pathway;Signal Transduction;Spinal Cord;Stereotyping;Therapeutic;therapeutic target;therapeutically effective;Tracer;TRPV channel;Vanilloid;Vascular Endothelial Cell;Work

PROJECT_TITLE: Defining TRPV4-mediated cytoskeletal changes that trigger pathological blood-neural barrier disruption

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BN-M (91)]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Disorders;Cerebrovascular;Machine Learning and Artificial Intelligence;Neurosciences;Stroke

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

PHR: Project narrative The proposed research aims to develop a comprehensive statistical and computational framework to predict the growth of unruptured intracranial aneurysms (UIA) growth at the 24th month as well as their growth trajecto- ries over a period of ﬁve years. Successful completion of the proposed research will provide a comprehensive computational system that will serve as a decision support tool for physicians managing patients with UIA. This information will also help physicians to assess the rupture risk of intracranial aneurysms, and to develop an appropriate plan for longitudinal surveillance based on the unique hemodynamics of a particular patient's UIA.

PI_NAMEs: JIANG, FEI  (contact)

PROGRAM_OFFICER_NAME: KUMSA, DOE WONDWOSSEN

PROJECT_TERMS: 4D MRI;Address;Aneurysm;Blood Flow Velocity;cardiovascular imaging;Categories;Cerebral Aneurysm;Cerebrovascular Disorders;cerebrovascular imaging;Clinical;clinical application;computer framework;Confidence Intervals;Data;Data Set;Death Rate;deep learning;Development;Evaluation;follow-up;Goals;Growth;hemodynamics;Image;improved;indexing;interest;Intracranial Aneurysm;Liquid substance;machine learning framework;Maps;Measures;Methodology;Methods;Modeling;Monitor;Morbidity - disease rate;novel;Outcome;Patients;Physicians;Polynomial Models;Population;prevent;Procedures;Research;Resolution;Risk;Risk Assessment;Rupture;Ruptured Aneurysm;simulation;Specific qualifier value;Statistical Models;success;support tools;surveillance imaging;Symptoms;System;Techniques;Technology;Testing;Time;time interval

PROJECT_TITLE: Statistical tensor regression models for intracranial aneurysm growth prediction

STUDY_SECTION: ASPA

STUDY_SECTION_NAME: Analytics and Statistics for Population Research Panel A Study Section[ASPA]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Neurosciences

ORG_CITY: OMAHA

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CREIGHTON UNIVERSITY

ORG_STATE: NE

PHR: PROJECT NARRATIVE Inner ear fluid homeostasis is essential for the proper function of the hearing and balance organs and defects in its regulation can lead to diseases such as Meniere's Disease. This project will identify the role of stress hormone receptors on endolymph and perilymph regulation. Results of this proposed work will advance our understanding of Meniere's disease and direct us toward the development of treatments to alleviate symptoms.

PI_NAMEs: RENAULD, JUSTINE MARIE (contact)

PROGRAM_OFFICER_NAME: WATSON, BRACIE

PROJECT_TERMS: absorption;Address;Adrenal Glands;Adrenal hormone preparation;Adrenalectomy;Adrenergic Agents;Adrenergic Receptor;Affect;Agonist;Aldosterone;Animal Model;antagonist;Apical;Auditory Threshold;Award;beta-2 Adrenergic Receptors;biological adaptation to stress;Biological Assay;Blood Vessels;career;Cells;Circadian Rhythms;Cochlea;Cochlear duct;common treatment;Comprehension;conditional knockout;Coupled;Defect;Development;Disabling;Disease;Edema;effective therapy;Electrophysiology (science);Emotional Stress;Endocrine;Endolymph;Endolymphatic Hydrops;endolymphatic sac;Epinephrine;Epithelium;Equilibrium;Etiology;experimental study;extracellular;Eye;Fluid Balance;Functional disorder;Glaucoma;Glucocorticoid Receptor;Glucocorticoids;Hearing;hearing impairment;Hearing problem;Histologic;Histology;Homeostasis;Hormone Receptor;Hormones;Human;Hydrocortisone;hydrocortisone receptor;Image;improved;in vivo;Injections;Intercalated Cell;Ion Channel;Ions;Knockout Mice;Labyrinth;Lateral;Ligation;Link;Liquid substance;Measures;Melatonin;Melatonin Receptors;Meniere's Disease;Methods;Microelectrodes;Modeling;Modification;Molecular;Morphology;Mosses;Mus;neurotransmission;normal hearing;old mice;Organ;Osmolalities;Outcome;Pathway interactions;Patients;Perilymph;Peripheral;permanent hearing loss;Permeability;Physiological;Physiology;Potassium;pressure;prevent;Production;Property;Proteins;receptor;Receptor Activation;Recurrence;reduce symptoms;Regulation;response;Role;Signal Transduction;Sodium;spatiotemporal;Specimen;Stress;Stria Vascularis;Symptoms;Temporal bone structure;Testing;therapy development;Universities;vasoconstriction;Vasodilation;Vertigo;vestibular system;Vestibule;Work

PROJECT_TITLE: Understanding the role of stress hormones in Meniere's disease


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Hearing Loss;Neurosciences

ORG_DEPT: OTOLARYNGOLOGY

PHR: Project Narrative Improving speech-perception abilities in people with cochlear synaptopathy requires detailed knowledge of the neural processing deficits underlying perceptual impairment. The proposed research project substantially expands our understanding of the specific aspects of auditory perception impacted by cochlear synaptopathy and underling neural mechanisms. Results will provide the fundamental knowledge that is essential to develop informed public health strategies to address cochlear synaptopathy.

PI_NAMEs: HENRY, KENNETH STUART (contact)

PROGRAM_OFFICER_NAME: POREMBA, AMY

PROJECT_TERMS: Acoustic Nerve;Acoustics;Address;Aging;Animal Model;Animals;Auditory;Auditory Perception;auditory processing;awake;base;Behavioral;behavioral impairment;behavioral study;Birds;Cell Nucleus;Clinical;Cochlea;cochlear synaptopathy;Communication;Complex;Cues;Data;Detection;Development;Discrimination;Disease;Electrodes;experimental study;Fiber;gain of function;Hair Cells;Hearing;hearing impairment;Hearing Tests;hidden hearing loss;Histologic;Human;Impairment;Implant;improved;Inner Hair Cells;insight;Kainic Acid;Knowledge;Labyrinth;Link;Mammals;Masks;Melopsittacus;Methodology;Methods;Midbrain structure;mimicry;Modeling;Mus;Nerve Fibers;nerve supply;neural;neuromechanism;neurophysiology;Noise;novel;Operant Conditioning;Parakeets;Pathology;Pattern;Perception;Peripheral;Persons;Physiological;Positioning Attribute;Procedures;Public Health;remediation;Research;Research Project Grants;Resolution;response;Signal Transduction;sound;Speech;Speech Perception;Stimulus;Testing;theories;Thinking;Time;Training;vision science;Work

PROJECT_TITLE: Behavioral and physiological consequences of auditory nerve loss

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative These studies target the precursor state to multiple myeloma, called monoclonal gammopathy of undetermined significance. It will test how specific bacteria can be involved in promoting the growth of tumor cells and dissect the mechanisms underlying inflammation induced by such bacteria. Targeting these triggers may lead to novel approaches for immune prevention of myeloma and improve outcome of these patients.

PI_NAMEs: DHODAPKAR, MADHAV V (contact);FLAVELL, RICHARD A;PALM, NOAH WOLCOTT

PROJECT_TERMS: African American population;Age Years;Animal Model;Antibiotic Therapy;Antibiotics;Antigens;Antimicrobial Effect;Autoimmunity;B-Cell Activation;B-Cell Antigen Receptor;B-Cell Neoplasm;B-Cell Receptor Binding;B-Lymphocytes;Bacteria;Binding;Biochemical;Biological;Biology;cancer immunotherapy;Cells;Cellular Immunology;Chronic;Clinical;clinical care;Clinical Research;Clinical Trials;Clone Cells;Collaborations;commensal bacteria;commensal microbes;cytokine;Data;Development;Dietary Intervention;Disease;Epidemiology;Evolution;Exhibits;follow-up;gammopathy;Gaucher Disease;Genetic;genetic approach;Growth;gut bacteria;gut microbes;gut microbiome;gut microbiota;Helicobacter pylori;High Prevalence;Human;human microbiota;human monoclonal antibodies;humanized mouse;Immune;immune activation;Immune system;Immunoglobulin A;Immunoglobulins;Immunology;Immunoprevention;improved outcome;in vivo;Individual;Inflammation;Inflammatory;insight;Intercept;Life Expectancy;Lymphoma;Malignant Neoplasms;Mediating;Methods;Microbe;microbial;microbial community;Modeling;Monoclonal Gammapathies;Monoclonal gammopathy of uncertain significance;mouse model;Mucosal Immunity;multidisciplinary;Multiple Myeloma;neoplastic;neoplastic cell;novel;novel strategies;Outcome;Pathogenesis;pathogenic bacteria;patient subsets;Patient-Focused Outcomes;Patients;Phase;Pilot Projects;Plasma Cell Neoplasm;Plasma Cells;pre-clinical;preclinical study;preneoplastic cell;Preneoplastic Conditions;prevent;Prevention;Productivity;Publishing;Research;Research Design;resident commensals;Risk;Stomach;Superantigens;Testing;tumor growth

PROJECT_TITLE: Targeting microbial triggers of gammopathy for immunoprevention


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Bioengineering;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: EUGENE

ORG_NAME: UNIVERSITY OF OREGON

ORG_STATE: OR

PHR: PROJECT NARRATIVE Electrode arrays are employed to record neural activity clinically to treat or inform the treatment of various neurological disorders, and in basic science research to understand neural circuits. This project develops a new high-density microelectrode array with unparalleled recording longevity. The project seeks to deliver electrode arrays that provide high-quality neural signals over longer periods to improve understanding of ongoing changes in neural circuits and the influence of different treatments on long-term patient outcomes.

PI_NAMEs: DEKU, FELIX  (contact)

PROGRAM_OFFICER_NAME: HWANG, GRACE MEI-HUA

PROJECT_TERMS: Acute;Address;Adoption;Affect;Aging;Animal Model;Basic Science;Brain;brain machine interface;carbon fiber;Chronic;Clinical;clinical application;clinical efficacy;Clinical Research;Clinical Treatment;Communication;Communities;Complex;Data;density;design;Devices;Dimensions;Ecosystem;Electrodes;Encapsulated;Engineering;Equilibrium;experience;experimental study;fabrication;Face;Failure;Film;flexibility;Geometry;Goals;Histologic;Human;Immune response;Implant;implantation;improved;In Vitro;in vivo;in vivo evaluation;Investigation;life span;lithography;Locked-In Syndrome;Longevity;Longitudinal Studies;manufacture;materials science;Mechanics;Medical;Metals;meter;Methods;Microelectrodes;Motor;Nervous System Disorder;neural;neural circuit;neural information processing;Neurosciences;Neurosciences Research;neurotechnology;neurotransmission;next generation;Patient-Focused Outcomes;Patients;Penetration;Performance;Pilot Projects;Preparation;Process;Production;Quadriplegia;Rattus;Research;Research Personnel;research study;Resolution;response;Saline;Series;Silicon;silicon carbide;Site;Songbirds;Stress;stress management;Structure;Techniques;Testing;Thick;Thinness;Tissues;tool;Uncertainty;Validation;Variant;Work

PROJECT_TITLE: Scalable fabrication of high-density amorphous silicon carbide microelectrode arrays for chronic neural interfacing

STUDY_SECTION: NSD

STUDY_SECTION_NAME: Neurological Sciences and Disorders D Study Section[NSD-D]


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Neurosciences

ORG_CITY: PASADENA

ORG_NAME: CALIFORNIA INSTITUTE OF TECHNOLOGY

PHR: Project Narrative The work in this project focuses on the generation and function of spontaneous motor actions and their top-down regulation in the brain. In humans, random variability in motor actions can play an important role in the ability to learn new motor tasks, but the execution of involuntary actions may also represent symptoms of underlying neurological diseases. Understanding the functional role and cellular basis of random movements and their internal regulation may reveal new avenues for understanding and treating neurological disorders involving the inability to either suppress or generate involuntary actions, including Tourette's syndrome, Huntington's chorea, and Parkinson's disease.

PI_NAMEs: BRUNTON, BINGNI WEN;DICKINSON, MICHAEL H (contact);VAN BREUGEL, FLORIS

PROGRAM_OFFICER_NAME: DAVID, KAREN KATE

PROJECT_TERMS: Address;Air;Altitude;Animals;Behavior;Behavioral;Brain;Cells;Communities;Complex;Computer Models;connectome;control theory;Custom;Databases;design;Down-Regulation;Ensure;Environment;Environmental Wind;experience;experimental study;fly;Flying body movement;Food;food environment;Foundations;Functional Imaging;Generations;Genetic;Genetic Techniques;Gilles de la Tourette syndrome;Goals;Human;Huntington Disease;Image;imaging system;individual response;Informatics;information gathering;instrument;Learning;Link;Literature;Maps;Measures;Mediating;member;Modeling;Motility;Motor;Movement;Nervous System;Nervous System Disorder;neural;Neurons;Neurosciences;Odors;optogenetics;Organism;Parkinson Disease;Periodicity;Physiology;Play;predictive modeling;Process;programs;Regulation;Research;Role;Saccades;Searching Behavior;Sensory;Smell Perception;Solid;Speed;statistics;Stereotyping;Stimulus;Symptoms;System;Techniques;Testing;theories;Time;two-photon;Visual;Work

PROJECT_TITLE: The Functional Role and Neural Basis of Rapid Turns in Olfactory Search Behavior

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 ICN-W (55)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Down Syndrome;Intellectual and Developmental Disabilities (IDD);Neurodegenerative;Neurosciences

PHR: Narrative  Alterations in mitochondrial ATP production and redox homeostasis in brain mitochondria are strongly associated with pathogenesis in Down syndrome (DS) and Alzheimer disease. We propose to optimize [18F]-BCPP-EF PET imaging for the robust assessment of Mitochondrial Complex I function in living individuals with DS and for whom alterations in mitochondrial bioenergetics are well established, with an overall goal of providing new in vivo information that contributes new knowledge about the risk for AD in people with DS.

PI_NAMEs: PRICE, JULIE C (contact);ROSAS, HERMINIA DIANA

PROGRAM_OFFICER_NAME: ROVESCALLI, ALESSANDRA C

PROJECT_TERMS: abeta accumulation;abeta deposition;Adult;Affinity;Age;age related;Aging;Alzheimer's Disease;Alzheimer's disease risk;Amyloid beta-Protein;Amyloid beta-Protein Precursor;Amyloid deposition;Area;ATP Synthesis Pathway;Atrophic;autosomal dominant Alzheimer's disease;Award;Axon;Bioenergetics;Brain;Cells;Cerebellum;cerebral atrophy;Chromosome 21;cognitive function;cohort;Complex;Corpus striatum structure;Data;data sharing;Deposition;Development;Developmental Process;Down's Syndrome;drug discovery;Early Onset Alzheimer Disease;Elderly;Electron Transport;extracellular;Failure;frontal lobe;Future;Generations;Glycolysis;Goals;Head;Health;Hippocampus;Homeostasis;human imaging;Image;imaging study;Impaired cognition;Impairment;in vivo;in vivo imaging;Individual;innovation;interest;Investigation;Kinetics;Knowledge;life span;Link;Magnetic Resonance Imaging;Maps;Measures;Mitochondria;mitochondrial dysfunction;multidisciplinary;Multienzyme Complexes;neural;Neurodegenerative Disorders;neuroimaging;Neurons;Neurophysiology - biologic function;non-demented;novel;Occipital lobe;Outcome;overexpression;Oxidation-Reduction;Oxidative Phosphorylation;Participant;Pathogenesis;Pattern;performance tests;Persons;Pilot Projects;Play;Population;Positron-Emission Tomography;Predisposition;Process;Production;radioligand;Reactive Oxygen Species;Reporting;Research;Research Project Grants;Respiration;Respiratory Chain;response;Risk;Role;Structure;Testing;Therapeutic;uptake;Work

PROJECT_TITLE: Imaging of Mitochondial Complex I function in Down Syndrome

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IVBH-B (56)]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences

ORG_CITY: LOS ANGELES

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Relevance. Strabismus is a common clinical disorder that can cause double vision in adults and vision loss in children. Strabismus is often treated by surgical manipulation of the eye muscles, although current knowledge of their structure and function is incomplete. Proposed functional imaging and biomechanical studies of the properties of the eye muscles, eyeball, and optic nerve will improve understanding of the causes and treatment of strabismus, optic nerve diseases, and nearsightedness.

PI_NAMEs: DEMER, JOSEPH LOUIS (contact)

PROGRAM_OFFICER_NAME: ARAJ, HOUMAM H

PROJECT_TERMS: 3-Dimensional;Accounting;adduct;Adult;Algorithms;Anatomy;Autopsy;Behavior;Benign;Biological Specimen Banks;biomechanical model;biomechanical test;Biomechanics;Blindness;Blood Vessels;Child;Choroid;Clinical;Complex;Computer Simulation;Computing Methodologies;Connective Tissue;Cranial nerve diseases;Cranial Nerves;crosslink;Cumulative Trauma Disorders;Deformity;Degenerative Myopia;Development;Diagnosis;digital imaging;Diplopia;Disease;Elements;Engineering;Epidemic;Equilibrium;Eye;Eye Banks;Eye Movements;Force of Gravity;Functional Imaging;Glaucoma;Head;Health;Human;Image;improved;In Vitro;in vivo;Individual;insight;kinematics;Knowledge;Lasers;Life;Magnetic Resonance Imaging;Measurement;Measures;mechanical force;mechanical properties;Mechanics;Medical;model development;Modeling;models and simulation;Modernization;Motility;Movement;Muscle;Muscle Contraction;Muscle function;Muscle Weakness;Myopia;Nerve Sheaths;novel;ocular imaging;Ocular orbit;Operative Surgical Procedures;Ophthalmoscopy;Optic Disk;Optic Nerve;optic nerve disorder;Optical Coherence Tomography;optical disc;optical imaging;orbit muscle;Papillary;Paralysed;Pathology;Pattern;Persons;Physiologic Intraocular Pressure;Play;Positioning Attribute;predictive modeling;Property;quantitative imaging;rapid eye movement;Recording of previous events;Relaxation;Resolution;Retina;Role;Rotation;Saccades;sample fixation;Scanning;Sclera;Shapes;Specimen;Speed;Strabismus;Stress;Structure;superior oblique muscle;Techniques;Testing;theories;Therapeutic;Time;Tissues;Variant;viscoelasticity;Vision Disorders;Visual

PROJECT_TITLE: Biomechanical Analysis in Strabismus Surgery

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-P (81)]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Clinical Research;Comparative Effectiveness Research;Data Science;Health Services;Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Patient Safety;Precision Medicine

ORG_DEPT: PSYCHIATRY

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: PROJECT NARRATIVE This proposal aims to address the lack of objective measures in psychiatry by leveraging advancements in computational approaches and incorporating rich behavioral data from clinical interviews, smartphones, and cognitive testing. The goal is to predict outcomes such as treatment (dis)continuation, hospitalizations, and ER visits for psychiatric patients in the first years of their illness. Leveraging the integrated Mount Sinai health system and bringing together a team of clinicians, AI experts and data scientists, our study aims to reimagine clinical phenotypes, using objective, scalable and cost-effective measurements, such as audiovisual recordings during clinical visits and data obtained from smartphones, to predict outcome in young help-seeking psychiatric patients.

PI_NAMEs: CECCHI, GUILLERMO ;CORCORAN, CHERYL MARY;KAHN, RENE S. (contact)

PROGRAM_OFFICER_NAME: MORRIS, SARAH ELIZABETH

PROJECT_TERMS: Address;Age;age group;aged;Appointment;Attention;Behavior;Behavior assessment;Behavioral;Cellular Phone;Clinic;Clinical;Clinical Data;clinical decision-making;clinical phenotype;Clinical Treatment;clinically relevant;Cognition;cognitive function;cognitive testing;cohort;Collaborations;Collection;Communities;community engagement;Computer Analysis;Computer software;cost;cost effective;critical period;Cues;Data;Data Analyses;Data Science;Data Scientist;Data Set;deep neural network;Development;Diagnosis;Diagnostic;diaries;digital;Electronic Health Record;electronic health record system;Emergency department visit;Emotions;Ethical Issues;ethnic diversity;experience;Eye;Face;Facial Expression;feature extraction;Foundations;Goals;health equity;Health system;help-seeking behavior;Hospitalization;implicit bias;impression;Individual;individual patient;Informed Consent;insight;Intake;Interview;Language;Life;Measurement;Measures;Medicine;Mental Health;Methods;Modeling;Natural Language Processing;Neural Network Simulation;New York;novel;Outcome;outcome prediction;Outcomes Research;Outpatients;Patients;personalized predictions;Persons;Phenotype;Physical activity;predictive signature;Privacy;Probability;Prognosis;Psychiatry;recruit;Sampling;sleep pattern;smartphone based assessment;Social Interaction;socioeconomics;Source;Surveys;Symptoms;Telephone;Testing;Text;Time;Travel;treatment and outcome;treatment planning;Update;Validation;Visit;Writing

PROJECT_TITLE: Phenotypes REimagined to Define Clinical Treatment and Outcome Research (PREDiCTOR)

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-S (01)]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Pediatric

ORG_CITY: PHILADELPHIA

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

ORG_STATE: PA

PHR: Over one-third of dysphonic children do not benefit from current voice therapies, a significant problem as dysphonia can result in negative health, psychosocial, and academic consequences. A crucial problem is that current therapies primarily rely on information gleaned from the adult vocal system, ignoring the critical fact that the pediatric system is still developing, and children are always adapting to these changes to maintain intelligible speech. The proposed research will provide an essential foundation to optimize pediatric therapies for voice disorders, shifting from a narrow focus on dysphonia to a broader focus on improving speech intelligibility.

PI_NAMEs: HELLER MURRAY, ELIZABETH SALMON (contact)

PROJECT_TERMS: Acoustics;Address;Adult;Affect;Age;Area;Articulation;Auditory;Bone callus;Boston;career;Child;Childhood;Clinical;clinical database;Clinical Trials Design;Communication;critical developmental period;Data;Dedications;design;Development;Disease;Dysphonia;early-career faculty;Education;effective therapy;Effectiveness;effectiveness testing;Emotional;Environment;Evaluation;Foundations;Glean;Goals;Grant;Growth;Health;Human;improved;individualized medicine;innovation;Left;Lesion;Measures;Medical center;Methods;National Institute on Deafness and Other Communication Disorders;Nodule;Outcome;Pattern;Pediatric Hospitals;pediatric patients;Perception;Philadelphia;Population;Production;programs;psychosocial;randomized, clinical trials;Randomized, Controlled Trials;Research;Sampling;Selection for Treatments;Severities;social;Speech;Speech Intelligibility;standard care;System;Testing;Therapeutic;Treatment Effectiveness;Treatment Efficacy;treatment optimization;Underserved Population;Universities;vocal cord;Voice;Voice Disorders;voice therapy;Vulnerable Populations

PROJECT_TITLE: Intelligibility and dysphonia in children with vocal fold nodules


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE Extensive health disparities exist in Alzheimer's disease (AD) and AD research for the Black community in that rates of AD are higher among Black individuals, yet there is a lack of research, and hence understanding, of their experience of this disease. Women show a more aggressive profile of AD than men with higher levels of the Alzheimer's causing pathological tau and a faster rate of clinical decline; inflammation and insulin resistance represent potential mechanisms for these differences given their sex disparities and ties to tau. Through a longitudinal observational study using blood-based markers of inflammation, insulin resistance, pathological tau, and measures of physical activity, we aim to answer the following questions in Black women: 1) How do levels of inflammatory markers and insulin resistance relate to changes in tau deposition and cognitive performance over time? 2) Does physical activity represent a protective factor against tau spread and cognitive decline, possibly through its beneficial effects on inflammation and insulin resistance? 3) How do social determinants of health impact these relationships?

PI_NAMEs: BANKS, SARAH  (contact);SUNDERMANN, ERIN ELIZABETH

PROGRAM_OFFICER_NAME: WAGSTER, MOLLY V

PROJECT_TERMS: Adult;Adverse effects;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease risk;Area;Automobile Driving;Biological;Biological Markers;Black Populations;Black race;black women;Blood;blood-based biomarker;Clinical;cognitive function;cognitive performance;cohort;Communities;community advisory board;community based participatory research;Decision Making;Deposition;deprivation;Diabetes Mellitus;Disease;Exclusion;experience;Health;health disparity;high risk population;High Risk Woman;Impaired cognition;indexing;Inflammation;inflammatory marker;Insulin Resistance;interest;Life Style;lifestyle factors;Link;Longitudinal, observational study;Los Angeles;Measures;men;modifiable risk;Modification;older adult;Outcome;Pathologic;Pathway interactions;Physical activity;Pilot Projects;Plasma;Prediabetes syndrome;Predisposition;Prevalence;prevent;Prevention;Prospective Studies;protective factors;Race;racial difference;racial disparity;recruit;Registries;Research;Risk Reduction;sex;sex disparity;Site;social determinants;social health determinants;tau aggregation;tau Proteins;tau-1;Time;Vulnerable Populations;White Women;Woman;women versus men;Women's study;Work

PROJECT_TITLE: Understanding Biological and Lifestyle Contributions to Alzheimer's Disease Pathology and Clinical Profiles in Black Women: Defining Prevention Targets in High Risk Groups

STUDY_SECTION: LCBH

STUDY_SECTION_NAME: Lifestyle Change and Behavioral Health Study Section[LCBH]


NIH_SPENDING_CATS: Biotechnology;Cancer;Immunization;Immunotherapy;Lung;Lung Cancer;Prevention;Tobacco;Tobacco Smoke and Health;Vaccine Related

ORG_CITY: COLUMBIA

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

ORG_STATE: MO

PHR: PROJECT NARRATIVE Breakthroughs in cancer immunotherapy pave the way for leveraging the power of immune system to prevent cancer in high-risk individuals with genetic predisposition or those exposed to environmental or occupational hazards. The overarching objective of this proposal is to test and develop a novel immune activating agent that has robust preventive efficacy against various cancer types, including cigarette smoke-induced lung cancer in preclinical animal models with direct relevance to the clinic. If efficacy is demonstrated, this molecule will significantly improve the battle against cancer with significant health and economic impact worldwide.

PI_NAMEs: SHIRWAN, HAVAL  (contact);YOLCU, ESMA S

PROGRAM_OFFICER_NAME: MOHAMMED, ALTAF

PROJECT_TERMS: Address;Agonist;Animal Model;Antibodies;Antigen Targeting;Antigens;Binding;cancer immunotherapy;Cancer Model;cancer prevention;cancer therapy;cancer type;CD8-Positive T-Lymphocytes;Cell Surface Proteins;cell type;cigarette smoke-induced;Clinic;Clinical;clinical development;clinical efficacy;clinical practice;clinical translation;clinically relevant;cohort;computed tomography screening;design;Development;Dose;economic impact;efficacy evaluation;Environmental Exposure;Environmental Hazards;Exhibits;Exposure to;Face;Failure;Funding;Genetic Predisposition to Disease;Goals;Health;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;high risk;high risk population;Human;humanized mouse;Immune;Immune system;Immunologic Adjuvants;Immunology;Immunoprevention;Immunotherapy;improved;Individual;innovation;Intercept;Knockout Mice;Ligands;Lung Neoplasms;Lung nodule;Malignant neoplasm of lung;Malignant Neoplasms;Modality;Modeling;mouse model;Mus;Nature;novel;occupational hazard;Pathway interactions;Patients;Pilot Projects;Play;pre-clinical;Pre-Clinical Model;Predisposition;prevent;Prevention;Preventive;Preventive vaccine;programs;receptor;Recombinants;Reporting;Resected;Risk;Rodent Model;Role;Scanning;Scientist;Series;Signal Transduction;Smoking History;success;Testing;tobacco control;Tobacco-Associated Carcinogen;Toxic effect;Treatment Efficacy;Treatment Protocols;tumor;Tumor Antigens;tumor immunology;Vaccines;Validation;Viral

PROJECT_TITLE: Developing a novel agonist of CD137 for cancer immunoprevention

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 RTRB-U (J1)]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: STONY BROOK

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

PHR: Project Narrative  New medical treatments and an aging population are increasing the pool of individuals that are susceptible to infections caused by the human fungal pathogen Candida albicans. Better therapeutic approaches are needed to treat C. albicans infections due to the limitations of current antifungal drugs and the emergence of drug resistant strains. The proposed studies will identify novel mechanisms that promote invasive growth of C. albicans into tissues, which can then be targeted in future studies to identify new antifungal strategies.

PI_NAMEs: KONOPKA, JAMES B (contact)

PROGRAM_OFFICER_NAME: LOVE, DONA

PROJECT_TERMS: Address;Affect;aging population;anti-fungal agents;Back;Binding;Binding Proteins;Blood Circulation;Candida;Candida albicans;Cell membrane;Cells;Defect;density;Disseminated candidiasis;Drug resistance;Endocytic Vesicle;Endocytosis;Endothelium;Environment;Epithelium;Future;Genes;Genetic Screening;Genetic Transcription;Goals;Golgi Apparatus;Growth;Human;Hyphae;In Vitro;in vivo;Individual;Infection;insight;Invaded;Knowledge;Life;LIM Domain;Liquid substance;Mammalian Cell;mechanotransduction;Mediating;Mediator;Medical;Microbial Biofilms;Microfilaments;Morbidity - disease rate;Morphogenesis;Morphology;mouse model;Mucous Membrane;mutant;new growth;novel;Oral candidiasis;Organism;oropharyngeal thrush;pathogen;Pathogenesis;pathogenic fungus;Pathway interactions;paxillin;Phosphorylation;Positioning Attribute;Predisposition;Process;Proteins;Recycling;Regulation;Reporting;Research;resistant strain;response;Role;Saccharomyces cerevisiae;Secretory Vesicles;Signal Pathway;Site;Stimulus;Stress;Systemic infection;Testing;Therapeutic;therapeutic development;Tissues;trafficking;Transcriptional Regulation;vesicular SNARE proteins

PROJECT_TITLE: C. albicans invasive growth

STUDY_SECTION: PTHE

STUDY_SECTION_NAME: Pathogenic Eukaryotes Study Section[PTHE]


ED_INST_TYPE: OVERALL MEDICAL

NIH_SPENDING_CATS: Chronic Pain;Diabetes;Hematology;Neurodegenerative;Neurosciences;Nutrition;Pain Research;Peripheral Neuropathy

ORG_CITY: HOUSTON

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: Project Narrative: Diabetic neuropathy often results in debilitating chronic pain or sensory loss that is inadequately managed by currently available therapies. This project seeks to determine how angiotensin-driven expansion and epigenetic modification of sensory nerve-adjacent myeloid cells causes chronic pain and neuropathy in type 2 diabetes. This pre-clinical validation of a crucial disease mechanism is highly likely to prove informative for management of diverse forms of neuropathy and chronic pain.

PI_NAMEs: SHEPHERD, ANDREW JOHN (contact)

PROGRAM_OFFICER_NAME: COOKE, BRAD

PROJECT_TERMS: Address;Affect;afferent nerve;Afferent Neurons;Angiotensin II;Angiotensin II Receptor;Angiotensins;Anti-Inflammatory Agents;Antiinflammatory Effect;Area;ATAC-seq;Behavior;behavioral study;Biological Assay;Cell Count;Cell Culture Techniques;Cell Physiology;Cells;chemokine;Chemotaxis;Chronic;Chronic Disease;chronic pain;Circulation;cytokine;Data;density;Development;Diabetes Mellitus;diabetic;Diabetic Neuropathies;Diet;Disease;disease model;Epigenetic Process;Flow Cytometry;Functional disorder;Functional Imaging;Generations;Genetic Models;Goals;Hematopoiesis;High Fat Diet;Hormonal;Human;human tissue;Hypersensitivity;Immunohistochemistry;imprint;In Situ Hybridization;In Vitro;in vivo;Inflammation;Inflammation Mediators;Inflammatory;inhibitor;injured;innovation;interdisciplinary approach;Investigation;Knowledge;Life Cycle Stages;Link;Lymphoid Tissue;Macrophage;Mediating;Metabolic syndrome;Modeling;Modification;Mus;Myelogenous;myeloid cell development;Myeloid Cells;Myelopoiesis;Nature;Nerve;nerve injury;Neuroimmune;Neuropathy;Non-Insulin-Dependent Diabetes Mellitus;non-opioid analgesic;novel strategies;Pain;Pain management;Pathologic;peptide hormone;Peptides;Peripheral Nervous System Diseases;Pharmaceutical Preparations;pharmacologic;Phenotype;polarized cell;Population;Positioning Attribute;pre-clinical;Production;Receptor Signaling;Renin-Angiotensin System;Role;Sensory;Signal Transduction;single-cell RNA sequencing;Site;Skin;skin biopsy;Testing;Therapeutic;therapeutic target;Tissues;transcriptomics;Translations;Traumatic Nerve Injury;Validation

PROJECT_TITLE: Angiotensin Signaling Underlies Myeloid and Sensory Disruption in Diabetes

STUDY_SECTION: NPI

STUDY_SECTION_NAME: Neurobiology of Pain and Itch Study Section [NPI]


NIH_SPENDING_CATS: Antimicrobial Resistance;Infectious Diseases;Urologic Diseases

ORG_CITY: Aurora

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: The proposed research is relevant to public health because it seeks to improve our understanding of the siderophore-mediated metal uptake process in uropathogenic E. coil, the leading cause of urinary tract infections. It will provide a concrete knowledge foundation for developing drugs to battle bacterial infections, which is relevant to the NIH’s mission.

PI_NAMEs: ZHENG, HONGJIN  (contact)

PROGRAM_OFFICER_NAME: ERNST, NANCY L

PROJECT_TERMS: Acceleration;Address;Adopted;Anti-Bacterial Agents;Antibiotic Resistance;Antibiotics;Applied Research;ATP-Binding Cassette Transporters;Bacteria;Bacterial Infections;Basic Science;Binding;Biochemistry;Biological Assay;Biological Process;Biophysics;carbapenem resistance;Cells;Characteristics;chelation;Chemicals;Circular Dichroism;Combating Antibiotic Resistant Bacteria;Computational Biology;Cryoelectron Microscopy;design;Development;drug development;Drug Targeting;Elbow;Exhibits;Experimental Animal Model;FDA approved;fighting;flexibility;Foundations;Future;Goals;Government;Gram-Negative Bacteria;high throughput screening;improved;In Vitro;Infection;inhibitor;innovation;insight;interdisciplinary approach;Intervention;Ions;Iron;Knowledge;Life;Lipid Binding;Lipids;Literature;Mass Spectrum Analysis;Mediating;Medical;Membrane;Metals;microbial;Microbiology;Mission;Modification;Molecular;Molecular Conformation;molecular dynamics;Mutagenesis;novel;Nucleotides;particle;pathogen;Pharmaceutical Preparations;Pharmacologic Substance;Physiological;Positioning Attribute;Process;protein folding;protein function;prototype;Public Health;Reporting;Research;research and development;resistant strain;Resolution;response;Siderophores;small molecule inhibitor;Solid;Structure;Structure-Activity Relationship;Techniques;Therapeutic;Therapeutic Intervention;Time;Trace Elements;translational impact;United States National Institutes of Health;uptake;Urinary tract infection;Uropathogenic E. coli;Vaccines;Work;yersiniabactin

PROJECT_TITLE: Molecular Mechanism of an Exporter-like ABC Importer YbtPQ

STUDY_SECTION: MSFA

STUDY_SECTION_NAME: Macromolecular Structure and Function A Study Section[MSFA]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Infectious Diseases

PHR: Project Narrative In this competitive renewal, we aim to gain a mechanistic understanding of IFN--mediated immunity and immunopathology during acute response to a common protozoan parasite Toxoplasma gondii at the site of infection.

PI_NAMEs: YAROVINSKY, FELIX  (contact)

PROGRAM_OFFICER_NAME: PESCE, JOHN T

PROJECT_TERMS: Acute;Address;Cell Death;Cells;Cessation of life;cytokine;Data;Dendritic Cells;Epithelial Cells;Epithelium;first responder;foodborne pathogen;FRAP1 gene;Funding;Genes;Goals;Host Defense;Host resistance;Immune response;Immunity;immunopathology;in vivo;Infection;innovation;Interferon Type II;Interferons;Interleukin-12;intestinal epithelium;intestinal homeostasis;Intestines;Lymphoid Cell;Macrophage;Mediating;Metabolic;microbial;migration;Molecular;monocyte;Mucosal Immunity;Mucous Membrane;Myeloid Cells;Natural Immunity;novel;oral infection;Paneth Cells;Parasites;pathogen;Pathologic;Pathology;Pathway interactions;Persons;Play;programs;Regulation;Research;response;Role;Route;Site;T-Cell Activation;Testing;Tissues;tool;Toxoplasma gondii;Toxoplasmosis;Work

PROJECT_TITLE: Mucosal immunity to Toxoplasma gondii

STUDY_SECTION: DHMI

STUDY_SECTION_NAME: Digestive System Host Defense, Microbial Interactions and Immune and Inflammatory Disease Study Section[DHMI]


ORG_CITY: BOSTON

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: Parkinson’s disease (PD) is associated with accumulation of alpha-synuclein, a protein that contributes to neurodegeneration. Neurons in PD have deficiency of PGC-1alpha, a master regulator of mitochondrial synthesis and antioxidant defenses, and this deficiency increases vulnerability to alpha-synuclein. Increased levels of another protein called FBXW7 may contribute to the PGC-1alpha deficiency, and we now propose to investigate key regulatory mechanisms for FBXW7 and PGC-1alpha, and to test our hypothesis that inhibition of FBXW7 is a promising therapeutic strategy for neuroprotection in PD.

PI_NAMEs: SIMON, DAVID K. (contact);WEI, WENYI

PROGRAM_OFFICER_NAME: SARRAF, SHIREEN AKHAVAN

PROJECT_TERMS: Acetylation;Affect;alpha synuclein;Alzheimer's Disease;Antioxidants;Apoptotic;Autophagocytosis;behavioral impairment;Biogenesis;Brain;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;Consensus Sequence;Data;Deacetylase;Deacetylation;dopaminergic neuron;EP300 gene;experimental study;FBXW7 gene;genetic regulatory protein;Genetic Transcription;Heterozygote;Impairment;in vivo Model;knock-down;Knock-out;Knockout Mice;MCL1 gene;MED15;Mediating;Mediator;Mitochondria;mitochondrial dysfunction;Molecular;Molecular Chaperones;motor behavior;mouse model;MPTP Poisoning;Mus;mutant;Mutation;Nerve Degeneration;neuronal survival;Neurons;neuroprotection;neurotoxicity;novel;overexpression;Oxidative Stress;p300/CBP-Associated Factor;Parkin;Parkinson Disease;Pathway interactions;Patients;Play;Predisposition;prevent;Process;Proteins;Regulation;Regulatory Pathway;Role;Signal Pathway;SIRT1 gene;Site;small hairpin RNA;Substantia nigra structure;Testing;Therapeutic;therapeutic target;Toxic effect;Ubiquitin;ubiquitin-protein ligase;Ubiquitination;Viral Vector

PROJECT_TITLE: Targeting the FBXW7/PGC1 Pathway as a Therapeutic Strategy for Parkinson's Disease

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biotechnology;Brain Disorders;Dementia;Gene Therapy;Genetics;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: SAINT LOUIS

ORG_DEPT: PHARMACOLOGY

ORG_NAME: SAINT LOUIS UNIVERSITY

PHR: Project Narrative Aging frequently results in a decline in cognitive abilities and loss of independence. Emerging data from experiments using mouse models and from cross-sectional studies in late-middle aged people suggest that increasing adropin signaling in the brain delays cognitive decline. This proposal tests antisense oligonucleotides (ASOs) designed to boost adropin signaling in the brain to enhance cognitive function in aged mice.

PI_NAMEs: BUTLER, ANDREW ALISTAIR (contact);NGUYEN, ANDREW D.

PROGRAM_OFFICER_NAME: RUNKO, ALEXANDER PETER

PROJECT_TERMS: 3' Untranslated Regions;Acceleration;Address;Adult;Affect;age group;aged;Aging;aging population;aging related;Alzheimer's disease related dementia;Amyotrophic Lateral Sclerosis;Antisense Oligonucleotide Therapy;Antisense Oligonucleotides;Biological;Biological Assay;Brain;brain tissue;Cell surface;Cells;Cerebral Ischemia;Clinic;cognitive ability;cognitive enhancement;cognitive function;cognitive performance;cognitive task;Collaborations;Communities;Cross-Sectional Studies;Data;Dementia;dementia risk;Demographic Transitions;design;drug development;Dyslipidemias;effective therapy;efficacy evaluation;Elderly;Exhibits;Experimental Designs;experimental study;Female;Foundations;Future;G-Protein-Coupled Receptors;gene network;Genes;genetic approach;Healthcare;high-throughput drug screening;Homeostasis;Human;human data;human disease;human old age (65+);Impaired cognition;improved;Injections;insight;Insulin Resistance;Intervention;Intravenous;intravenous administration;intravenous injection;Investments;Knowledge;Laboratory Animal Models;Late Onset Alzheimer Disease;Lead;Learning;Ligands;Link;Long-Term Care for Elderly;male;Managed Care;Mediating;Memory;Memory impairment;Messenger RNA;Metabolic;Methods;MicroRNAs;middle age;mild cognitive impairment;mouse model;mRNA Expression;mRNA Stability;mRNA Translation;Mus;Nerve Degeneration;Nervous System;Neurodegenerative Disorders;nonhuman primate;novel therapeutics;old mice;older adult;oligonucleotide delivery;Orphan;overexpression;Peptides;Performance;Peripheral;Personality;Persons;Pharmaceutical Preparations;Pharmacology;Pharmacotherapy;Plasma;Population;pre-clinical;preclinical study;Preclinical Testing;Prevalence;prevent;Production;Productivity;protein expression;Proteins;Publishing;receptor;Reporting;Risk;Risk Reduction;Rodent Model;screening;senescence;Signal Pathway;Signal Transduction;Site;Societies;Solid;Testing;Therapeutic;Time;Tissues;transcriptome sequencing;Transgenic Mice;Transgenic Organisms;Translations;United States;Work

PROJECT_TITLE: Methods for treating aging-related cognitive decline and reducing risk of AD/ADRD by enhancing the endogenous expression of adropin

STUDY_SECTION: DMPB

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology B Study Section[DMPB]


ADMINISTERING_IC: DA

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Drug Abuse (NIDA only);Stem Cell Research;Stem Cell Research - Embryonic - Non-Human;Substance Misuse

ORG_CITY: BALTIMORE

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: This application for an administrative supplement is submitted to meet the objectives of RFA-DA-21-006 and is submitted under that funding mechanism. We are seeking supplemental funds for U01DA056556, “Tools for gene editing in marmosets,” to enable a collaboration with Dr. Ali Brivanlou’s laboratory at Rockefeller University (RU). The IVF resources for marmosets at Johns Hopkins (JHU) will provide synergism with RU to develop new stem cell lines and ultimately create genetically modified marmoset models of neurodegenerative diseases.

PI_NAMEs: SEGARS, JAMES H.;WANG, XIAOQIN  (contact)

PROGRAM_OFFICER_NAME: WU, DA-YU

PROJECT_TERMS: Administrative Supplement;Benchmarking;blastocyst;Callithrix;Callithrix jacchus jacchus;Cell Line;Cells;Chimera organism;Clone Cells;Collaborations;Communities;Disease;Dissociation;Embryo;embryo cell;Embryonic Development;Exhibits;experience;experimental study;Female;Fluorescence;Funding;Funding Mechanisms;GAG Gene;gene editing technology;Gene Modified;Gene Transfer Techniques;Generations;Genes;Germ Lines;Growth;Herpes zoster disease;Injections;Laboratories;Methods;Modeling;Nerve Degeneration;Neurodegenerative Disorders;Neurodevelopmental Disorder;offspring;Phase;Pluripotent Stem Cells;Primates;Reporter;Research;Research Personnel;Resources;stem cells;success;synergism;tool;Transgenic Organisms;transmission process;Universities

PROJECT_TITLE: Tools for gene editing in marmosets


ORG_CITY: CHICAGO

ORG_DEPT: PHYSIOLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: Project Narrative In temporal lobe epilepsy (TLE), the ratio of excitation over inhibition is commonly unbalanced in the microcircuits of a brain region called subiculum, which often initiates pathological activity and eventually triggers seizures. We have collected preliminary data showing that the exposure of subicular tissue to a neurotrophin whose levels are increased in TLE (brain-derived neurotrophic factor, BDNF) transforms physiological inhibition mediated by a specific population of GABAergic interneurons (parvalbumin-expressing cells, PVs) into excitation and dramatically alters network signaling by recruiting polysynaptic excitatory circuits. We propose to use of a variety of state-of-the-art techniques to investigate at the highest resolution the cell type- specific mechanisms involved in the abnormal activation of these polysynaptic excitatory circuits, which is important for the identification of novel molecular/cellular therapeutic targets.

PI_NAMEs: MACCAFERRI, GIANMARIA  (contact)

PROGRAM_OFFICER_NAME: CHURN, SEVERN BORDEN

PROJECT_TERMS: Anatomy;anti-epileptic agents;biophysical analysis;biophysical properties;Brain;Brain region;Brain-Derived Neurotrophic Factor;Carbamazepine;Cell Therapy;cell type;Cells;chloride-cotransporter potassium;Data;Development;Down-Regulation;Electrophysiology (science);Elements;Epilepsy;epileptiform;Event;experimental study;Exposure to;gamma-Aminobutyric Acid;Generalized seizures;Generations;Glutamates;Hippocampal Formation;In Vitro;Individual;inhibitory neuron;Interneurons;Mediating;Membrane;Modeling;Molecular;nerve supply;neural;Neurons;neurotrophic factor;novel;novel therapeutic intervention;optogenetics;Output;Parvalbumins;patch clamp;Pathologic;Pathway interactions;pharmacologic;Phenytoin;Physiological;Population;postsynaptic;presynaptic;prevent;Property;Protocols documentation;Pyramidal Cells;receptor;recruit;Recurrence;Resolution;response;Role;Seizures;Signal Transduction;Slice;Somatostatin;Specificity;Synaptic Potentials;Techniques;Temporal Lobe Epilepsy;Testing;theories;therapeutic target;Tissues;transmission process

PROJECT_TITLE: Microcircuits of the Subiculum and Epilepsy

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


NIH_SPENDING_CATS: Neurosciences;Pediatric;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: NEWARK

ORG_DEPT: BIOLOGY

ORG_NAME: RUTGERS THE STATE UNIV OF NJ NEWARK

ORG_STATE: NJ

PHR: Normal brain development depends on generating the appropriate numbers of cells of different lineages, and how that is regulated is not well-understood. The p75 neurotrophin receptor is abundantly expressed in a population of intermediate progenitor cells in the rat subventricular zone. Deletion of p75NTR results in precocious differentiation and maturation of oligodendrocytes, and may be a mechanism for regulating the timing and balance between generating differentiated cells while maintaining a pool of immature progenitors.

PI_NAMEs: FRIEDMAN, WILMA J (contact)

PROGRAM_OFFICER_NAME: TYLER, WILLIAM A

PROJECT_TERMS: Acceleration;Adult;Age Months;aged;Brain;Brain region;Cell Cycle;Cell Differentiation process;Cell Lineage;Cell Maturation;Cell Separation;cell type;Cells;Cerebellum;Data;Demyelinations;Development;Equilibrium;experimental study;Generations;gliogenesis;granule cell;Human;In Vitro;in vivo;Knock-out;lateral ventricle;Lesion;Life;life span;LoxP-flanked allele;Mus;Myelin;myelination;nestin protein;Neuroglia;Neurons;NGFR Protein;novel;oligodendrocyte lineage;oligodendrocyte progenitor;Oligodendroglia;Population;postnatal;postnatal development;premature;prevent;Production;progenitor;Proliferating;Rattus;receptor;receptor expression;receptor function;Regulation;remyelination;Role;stem cell biomarkers;Stem Cell Development;stem cell differentiation;stem cell population;stem cell proliferation;stem cells;subventricular zone;transcriptome sequencing;white matter

PROJECT_TITLE: p75NTR regulates oligodendrocyte progenitor development in the SubventricularZone of postnatal rats

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BN-N (03)]


NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Biomedical Imaging;Clinical Research;Hearing Loss;Neurosciences;Prevention;Rehabilitation

ORG_CITY: WEST LAFAYETTE

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: Project Narrative Hearing loss imparts functional changes not only to the peripheral auditory system, but also to the cortical auditory system in the brain. A cochlear implant (CI) can restore auditory input directly to the periphery, but our understanding is limited as to how the brains of individual CI users process this speech input. The proposed studies will conduct the developmental work to improve a CI-compatible neuroimaging tool to investigate the impact of individual differences in cortical-speech processing on the speech-recognition outcomes in adult CI users.

PI_NAMEs: SHADER, MAUREEN JOYCE (contact)

PROGRAM_OFFICER_NAME: KING, KELLY ANNE

PROJECT_TERMS: Accounting;Address;Adult;Area;Auditory;Auditory area;auditory rehabilitation;Auditory system;Brain;career;Clinical;clinical practice;Cochlea;cochlear development;Cochlear Implants;cost;deafness;design;Development;Devices;Electromagnetics;flexibility;Functional Magnetic Resonance Imaging;functional near infrared spectroscopy;Goals;Hearing;hearing impairment;heart rate variability;Image;Implant;implant compatibility;implantable device;Implanted Electrodes;improved;Individual;Individual Differences;individual variation;interest;Investigation;Knowledge;Measurement;Measures;metallicity;Methodology;Methods;Morphologic artifacts;National Institute on Deafness and Other Communication Disorders;neural;neuroimaging;neurotransmission;new technology;normal hearing;novel;Operative Surgical Procedures;Optics;Outcome;Oxygen;Patients;Pattern;Peripheral;personalized approach;personalized medicine;Persons;Physiological;Physiology;Population;prevent;Process;Prosthesis;Qualifying;Recording of previous events;Reporting;Research;Risk;Route;Scanning;sensory prosthesis;Signal Transduction;skills;Source;spectroscopic imaging;Speech;speech processing;speech recognition;Stimulus;Structure;success;Technology;Telephone;Testing;tool;Training;Translating;Uncertainty;United States;Work

PROJECT_TITLE: Reliable measures of functional cortical processing of speech in adult cochlear-implant recipients

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Genetics;Hematology;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: PROJECT NARRATIVE We hypothesize that mutant p53 enhances inflammatory stress via activating the NLRP1 inflammasome and increasing the secretion of proinflammatory cytokines, thereby generating a chronic inflammatory microenvironment that inhibits wild type (WT) hematopoietic stem and progenitor cell (HSPC) fitness in a paracrine fashion. We further speculate that reducing chronic inflammation will prevent or delay the progression of TP53 mutant clonal hematopoiesis to myelodysplastic syndromes (MDS).

PI_NAMEs: LIU, YAN  (contact)

PROGRAM_OFFICER_NAME: BAI, C BRIAN

PROJECT_TERMS: Age;aged;Aging;Antibodies;Antibody Therapy;aposome;ATAC-seq;Bacterial Infections;Biological Assay;Blood;Bone Marrow;CASP1 gene;Cell Death;Cells;Chromatin;Chronic;Clinical Research;Clonal Expansion;Coculture Techniques;cytokine;Development;DNA sequencing;Dysmyelopoietic Syndromes;Engraftment;EZH2 gene;fitness;Funding;Genetic;Hematologic Neoplasms;Hematopoiesis;hematopoietic stem cell expansion;Hematopoietic stem cells;Human;in vivo;Individual;Infection;Inflammasome;Inflammation;Inflammatory;Inflammatory Response;inhibitor;Interleukin-1 beta;Interleukin-6;Knowledge;Lipopolysaccharides;Longitudinal Studies;Molecular;Multiprotein Complexes;Mus;mutant;Mutant Strains Mice;Mutate;Mutation;Myeloproliferative disease;neutralizing antibody;new therapeutic target;novel strategies;paracrine;Pathologic;Patients;peripheral blood;pharmacologic;prevent;Reporting;Research;Resistance;Risk;Serum;Signal Transduction;stem cell expansion;Stress;Testing;TP53 gene;transcriptome sequencing;Transplantation

PROJECT_TITLE: Molecular mechanism underlying clonal expansion of hematopoietic stem cells

STUDY_SECTION: BBHV

STUDY_SECTION_NAME: Basic Biology of Blood, Heart and Vasculature Study Section [BBHV]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Health Services;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Primary Health Care;Serious Mental Illness;Social Determinants of Health;Telehealth

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

PHR: Project Narrative Medicaid enrollees with mental illness have high rates of unmet mental health needs and are more likely than the general population to experience poor health outcomes. Medicaid managed care organizations contract with sets of specialty providers to deliver mental health care to these enrollees, but little evidence exists to guide how provider networks can be leveraged to improve access to care and health outcomes. The objective of this proposal is to estimate the effects of mental health networks on health care utilization, quality, and clinical outcomes for Medicaid enrollees, in order to provide policy-relevant, actionable evidence to inform the design, monitoring, and regulation of mental health provider networks in the context of critical mental health delivery system constraints.

PI_NAMEs: ZHU, JANE MINGJIA (contact)

PROGRAM_OFFICER_NAME: HUMENSKY, JENNIFER L

PROJECT_TERMS: Acute;acute care;Adherence;Adult;Advisory Committees;Affect;behavioral health;beneficiary;Bipolar Disorder;care outcomes;Caring;Clinical;Collaborations;Continuity of Patient Care;Contracts;Cost Sharing;Data;design;Diagnosis;District of Columbia;Emergency Situation;Ensure;experience;Exposure to;Face;General Population;health care availability;health care delivery;Health care facility;health care service utilization;health care settings;Health Personnel;Health Services Accessibility;Healthcare;Improve Access;improved;Information Systems;innovation;Knowledge;Managed Care;Measurement;Measures;Mediating;Medicaid;Medical;medical specialties;medication compliance;member;Mental disorders;Mental Health;mental health policy;Mental Health Services;Methodology;Monitor;National Institute of Mental Health;Nurse Practitioners;Outcome;Outpatients;Patient advocacy;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;physical conditioning;Policies;policy recommendation;poor health outcome;Population;programs;Provider;provider networks;Proxy;Psychiatric Nursing;Psychiatrist;Quality of Care;Regulation;Reporting;Research Design;Schizophrenia;Self-Injurious Behavior;service utilization;Services;severe mental illness;suicidal;System;telehealth;Telemedicine;Treatment outcome;United States Centers for Medicare and Medicaid Services;Visit

PROJECT_TITLE: The Effects of Provider Networks on Medicaid Enrollees with Mental Health Conditions

STUDY_SECTION: SERV

STUDY_SECTION_NAME: Mental Health Services Study Section[SERV]