NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities

PI_NAMEs: SMITH, KELLY D (contact)

PROJECT_TERMS: Aliquot;American;Authorization documentation;biobank;Biopsy;Blood;Blood specimen;Body Fluids;Businesses;cancer cell;Cancer Center Support Grant;Cell Survival;Cells;Characteristics;Clinical;Clinical Laboratory Improvement Amendments;Clinical Pathology;Clinical Research;Clinical Trials;Collection;college;Computerized Medical Record;Consent;Controlled Environment;Correlative Study;cost effectiveness;Data;data de-identification;data handling;Diagnostic;digital pathology;Eligibility Determination;Enrollment;Fresh Tissue;Future;Generations;Grant;Health Insurance Portability and Accountability Act;hospital laboratories;Hospitals;Human;human tissue;Imaging technology;improved;Informatics;Information Systems;Institutional Review Boards;Joints;Laboratories;laboratory development;Location;manufacture;Measurement;Medical Records;medical schools;Medicine;Methods;Mission;Modeling;novel;Operating Rooms;operation;participant enrollment;Pathologic;Pathologist;Pathology;pathology imaging;Pathway interactions;patient registry;Patients;Policies;preservation;Process;programs;prospective;Protocols documentation;Radiology Specialty;Regulation;repository;Research;Research Personnel;research study;Resource Sharing;Sampling;satisfaction;Scanning;Services;Slide;Specific qualifier value;Specimen;Stains;Support System;System;Testing;Time;Tissue Banks;Tissue Microarray;Tissue Preservation;Tissue Procurements;Tissue Viability;Tissues;Toxic effect;Translational Research;translational study;treatment response;tumor;Universities;Visit;waiver;Washington;whole slide imaging

PROJECT_TITLE: Shared Resource: Northwest Bio


ADMINISTERING_IC: OD

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Cancer;Dental, Oral, and Craniofacial Disease;Immunotherapy;Lymphatic Research;Orphan Drug;Radiation Oncology;Rare Diseases

ORG_CITY: FORT COLLINS

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_FIPS: US

ORG_NAME: COLORADO STATE UNIVERSITY

ORG_STATE: CO

PHR: Project Narrative The prognosis is poor for patients with advanced head and neck cancer (HNC) and scientists are investigating whether radiotherapy and immunotherapy combinations can improve treatment outcomes; however, HNC patients with high risks for regional metastasis typically receive RT targeted to their primary tumor site as well as regional lymph nodes (RLN) in order to eradicate latent metastatic tumor cells. Using translational animal models, including orthotopic murine head and neck cancer and spontaneous canine oral carcinoma, we will define the impact of regional lymph node irradiation on the anti-tumor immune response for patients with head and neck cancer treated with RT and immunotherapy (IO). If we demonstrate RT+IO and RLN sparing improves outcomes in translational preclinical models of advanced HNC, the results of this project would challenge the current standard of care and clinical paradigm surrounding radiation, immunotherapy, and elective RLN irradiation for patients with advanced HNC.

PI_NAMEs: BOSS, MARY-KEARA  (contact)

PROGRAM_OFFICER_NAME: TANDON, RITESH

PROJECT_TERMS: advanced disease;Affect;Agonist;Animal Model;anti-tumor immune response;antigen-specific T cells;Antigens;Antitumor Response;Archives;Automobile Driving;B-Lymphocytes;Biological Assay;Blood;Board Certification;Cancer Model;Cancer Patient;canine model;Canis familiaris;Carcinoma;career;career development;CD8B1 gene;Cell Density;Cells;Clinical;Clinical Data;clinically relevant;Combination immunotherapy;Combined Modality Therapy;comparative;Data;design;Dose;draining lymph node;effector T cell;Europe;experimental study;Flow Cytometry;Goals;Head and Neck Cancer;head and neck cancer patient;high risk;Human;Immune;Immune response;Immunity;Immunohistochemistry;Immunologics;Immunology;immunosuppressed;Immunotherapy;improved;improved outcome;Inflammatory;innovation;interest;irradiation;Ligands;Lymph Node Tissue;lymph nodes;Mentorship;Metastatic Neoplasm to Lymph Nodes;Monoclonal Antibodies;mouse model;Mouth Carcinoma;Mus;Natural Killer Cells;neoplasm immunotherapy;Neoplasm Metastasis;neoplastic cell;novel strategies;novel therapeutics;OX40;Pathway interactions;patient response;Patient-Focused Outcomes;Patients;Phenotype;Physicians;Population;pre-clinical;Pre-Clinical Model;Primary Neoplasm;Prognosis;Program Development;Radiation;radiation effect;Radiation Oncologist;Radiation therapy;Regulatory T-Lymphocyte;Reporting;Research;Rodent;Role;Sampling;Scientist;Site;standard of care;T cell response;T-Cell Depletion;Testing;transcriptome sequencing;translational cancer research;translational scientist;Treatment outcome;tumor;tumor growth;Tumor Immunity;tumor microenvironment;United States

PROJECT_TITLE: Impact of lymph node sparing on the anti-tumor response for head and neck cancer treated with radiation and immunotherapy


ADMINISTERING_IC: CA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: Not applicable to P30 CCSG as stated in the FOA PAR-17-095.

PI_NAMEs: ADAMS, JAMES B (contact)

PROJECT_TERMS: Adherence;anti-cancer research;Area;Bar Codes;Biological;Biological Products;Cancer Center Support Grant;cancer prevention;cancer therapy;Cell Therapy;Cells;Clinic;Clinical;Clinical Management;clinical practice;Clinical Research;Clinical Trials;Collaborations;Communication;Complex;Computer software;cost effective;Detection;Development;Diagnosis;Employee;Ensure;Equipment;Equipment and supply inventories;Evaluation;Faculty;Future;gene therapy;Goals;Good Manufacturing Process;Human Resources;improved;Institution;Investments;Malignant Neoplasms;manufacture;manufacturing facility;member;Modality;Modernization;next generation;Output;patient safety;Patient-Focused Outcomes;Performance;Phase;pre-clinical;prevent;Process;process optimization;Production;programs;Provider;Qualifying;quality assurance;Quality Control;recruit;Research;Research Personnel;Resource Development;Resource Sharing;Resources;Safety;satisfaction;Scientific Advances and Accomplishments;Scientist;Services;Structure;success;System;Talents;Technology;technology platform;Testing;Therapeutic;Training;Training Programs;Translating;translational potential;Universities;Update;Vision;Washington

PROJECT_TITLE: Shared Resource: Therapeutic Manufacturing

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Behavioral and Social Science;Neurosciences

ORG_CITY: SALT LAKE CITY

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE A national challenge in the biomedical sciences is to recruit, train, and retain the broadest and most diverse scientific talent pool possible. At the University of Utah, we are poised to tackle this challenge by leveraging our recent successes in recruiting underrepresented students into our graduate programs and extending our efforts to the postbaccalaureate population. We will establish the IDEAS in Neuroscience Program to support the intellectual, professional, and scientific development of trainees from underrepresented backgrounds who had limited access to research experience during their undergraduate training so that they can flourish and continue on the path to a career in biomedical science.

PI_NAMEs: O'CONNELL, RYAN M;WILCOX, KAREN S (contact)

PROGRAM_OFFICER_NAME: MATTHEWS, MARGUERITE

PROJECT_TERMS: Address;Admission activity;Biomedical Research;career;Career Choice;college;combat;Communication;Communities;community building;Critical Thinking;cultural competence;Custom;Dedications;design;Development;Development Plans;Disadvantaged;Discrimination;diversity and inclusion;Doctor of Philosophy;doctoral student;Early Intervention;Education;Educational Curriculum;Educational workshop;equity, diversity, and inclusion;expectation;experience;Faculty;Family;Fortification;Future;Goals;Graduate Degree;Graduate Education;graduate school;graduate student;Hispanic-serving Institution;Immersion;Individual;Infrastructure;innovation;Institution;Interview;Knowledge;Latino;Lead;Life;matriculation;meetings;member;Mentors;Mentorship;Minority-Serving Institution;Mission;Native American community;neuroimmunology;Neurosciences;Oral;peer;peer coaching;peer support;Personal Satisfaction;Polishes;Population;Positioning Attribute;Postbaccalaureate;Postdoctoral Fellow;Privatization;Probability;Process;programs;recruit;Research;Research Project Grants;Research Training;resilience;role model;Science;Self Efficacy;senior faculty;skills;social;student participation;Student recruitment;Students;success;Syndrome;System;Talents;Time;tool;Training;Training Programs;undergraduate student;Underrepresented Students;Universities;Utah;Workplace;Writing

PROJECT_TITLE: Intermountain Doctoral Education to Advance Students (IDEAS) in Neuroscience


PI_NAMEs: MIYAOKA, ROBERT S (contact)

PROJECT_TERMS: Adoption;Animal Experimentation;animal imaging;Animals;anti-cancer research;archive data;bioimaging;Budgets;Cancer Center Support Grant;Complement;Computer software;Consult;Consultations;cost;cost effective;cost efficient;Data;data acquisition;Data Analyses;data archive;Disease;Equipment;experience;experimental study;Faculty;Funding;Home;Housing;Human;Human Resources;IACUC;Image;Image Analysis;imaging biomarker;imaging modality;imaging study;imaging system;Imaging technology;in vivo imaging;Individual;Institution;instrumentation;inter-institutional;Longitudinal Studies;Magnetic Resonance Imaging;Malignant Neoplasms;Medical center;member;Microscope;Modality;Modeling;operation;optical imaging;Optics;Positron-Emission Tomography;pre-clinical research;Process;prospective;Protocols documentation;proton beam;Radiation;Research;Research Design;Research Personnel;Research Project Grants;Resource Sharing;Resources;Role;Running;Schedule;Scientist;service utilization;Services;Site;skills;Specialist;Specimen;System;Training;translational goal;Transportation;treatment response;two-photon;Ultrasonography;ultrasound;Universities;Visual;Washington;Work;Workload;Writing;X-Ray Computed Tomography

PROJECT_TITLE: Shared Resource: Translational BioImaging


PI_NAMEs: GOOLEY, TED  (contact)

PROJECT_TERMS: Address;Advisory Committees;anti-cancer research;Applications Grants;Award;Awareness;Biological;Biological Markers;Biometry;Biostatistics Shared Resource;Budgets;Cancer Center Support Grant;Cancer Survivorship;Clinical;Clinical Trials Design;Collaborations;Data;Data Analyses;data integration;Dedications;Development;Diagnostic tests;Differential Equation;Ensure;experience;Faculty;Feedback;Funding;Genetic;Genomics;Grant;improved;innovation;kernel methods;Laboratory Scientists;member;metabolomics;Methods;microbiome;Modeling;multidimensional data;multiple omics;Pathway Analysis;Phase;Population;predictive modeling;Probability;programs;Proteomics;Research;Research Contracts;Research Personnel;Research Project Grants;Resource Sharing;Risk;satisfaction;Series;Services;skills;Statistical Methods;Survival Analysis;Time;United States National Institutes of Health

PROJECT_TITLE: Shared Resource: Biostatistics


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Contraception/Reproduction;Diabetes;Dissemination and Implementation Research;Infertility;Nutrition;Obesity;Pediatric;Physical Activity;Polycystic Ovary Syndrome (PCOS);Prevention;Women's Health Research

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Polycystic ovary syndrome (PCOS) is a common endocrine condition affecting adult women, with significant comorbidities including diabetes, cardiovascular disease, and infertility. The earliest signs of PCOS appear in peripubertal females, representing an important opportunity for prevention. However, there is limited data on targeting at-risk girls for preventive interventions. This career development award will take a stepwise approach in examining the development of PCOS risk among young females in relation to physical activity behaviors, followed by a structured plan to refine and pilot a targeted physical activity intervention for peripubertal girls.

PI_NAMEs: WHOOTEN, RACHEL  (contact)

PROGRAM_OFFICER_NAME: LINDER, BARBARA

PROJECT_TERMS: actigraphy;Adolescence;adolescent woman;Adult women;Advisory Committees;Affect;Age;Androgens;Area;Attenuated;Behavior;Behavior Therapy;Behavioral;Biometry;Cardiovascular Diseases;career;Caregivers;Childhood;Chronic Disease;Clinical;Clinical Trials Design;cohort;Collection;Communities;comorbidity;Complex;critical period;Data;design;Development;Diabetes Mellitus;disorder prevention;Dissemination and Implementation;early adolescence;effective intervention;efficacy trial;Endocrine;Endocrine Physiology;Endocrinologist;Enrollment;Epidemiology;evidence base;exercise intervention;feasibility testing;Female;Female Adolescents;Focus Groups;follow-up;Functional disorder;girls;Goals;Health;Health behavior;Health Care Costs;Health Services;High Risk Woman;Hormones;Hyperandrogenemia;implementation intervention;implementation science;improved;Infertility;insight;Insulin;Insulin Resistance;insulin sensitivity;Intervention;intervention participants;Irregular Menstruation;K-Series Research Career Programs;Knowledge;Lead;Life Cycle Stages;Literature;longitudinal analysis;Longitudinal cohort;Measurement;Measures;Mental Depression;Mentored Patient-Oriented Research Career Development Award;Mentorship;Metabolic;Metabolic Diseases;metabolomics;Methods;Morbidity - disease rate;multidisciplinary;National Institute of Diabetes and Digestive and Kidney Diseases;Natural History;Obesity;obesity prevention;Outcome;Phenotype;Physical activity;Physiological;pilot trial;Polycystic Ovary Syndrome;Prevention;Prevention strategy;preventive intervention;Primary Prevention;Process;Puberty;Public Health;Randomized;reproductive;Reproductive Health;Research;Research Personnel;Research Priority;Risk;Series;skills;Strenuous Exercise;Structure;Target Populations;Teenagers;therapy design;Time;tool;Training;Treatment Efficacy;Woman;Work;young woman

PROJECT_TITLE: Investigating the impact of physical activity in modulating PCOS risk among peripubertal females

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


NIH_SPENDING_CATS: Cancer

PI_NAMEs: DUGGAN, CATHERINE ROSE (contact)

PROJECT_TERMS: Advisory Committees;Area;base;Biological Specimen Banks;Biomedical Research;biomedical resource;Cancer Center Support Grant;Client;Clinical;cost effective;cost effectiveness;Data;data infrastructure;data management;Data Science;data sharing;Data Storage and Retrieval;Databases;design;Development;electronic data;Enrollment;Epidemiologist;Faculty;Funding;Goals;Health Sciences;Individual;Infrastructure;innovation;Interview;Interviewer;Maintenance;Malignant Neoplasms;Manuscripts;member;Mission;new technology;novel;operation;Outcome;Participant;Patient Recruitments;Peer Review;personalized approach;population health;Process;programs;Public Health Applications Research;Publications;recruit;Research;Research Activity;Research Project Grants;research study;Resource Sharing;Resources;Secure;Services;Support System;Surveys;Systems Integration;Techniques;Technology;tool;Training;Translational Research;Universities;Washington

PROJECT_TITLE: Shared Resource: Collaborative Data Services


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Nutrition;Obesity;Physical Activity;Prevention

PI_NAMEs: CHOW, ERIC JESSEN (contact)

PROJECT_TERMS: abdominal fat;Affect;Anthropometry;Behavior;Behavioral;biological research;Biology;Biometry;Biopsy;Body Composition;Breast;Cancer Center Support Grant;cancer epidemiology;Cancer Etiology;Cancer Survivor;Certification;Clinic;Clinical;Clinical assessments;Clinical Research;Collection;Communities;Computational Biology;cost;Data Collection;design;Development;Diet;Dietary Intervention;Dual-Energy X-Ray Absorptiometry;epidemiology study;Equipment;Exercise;exercise physiologist;exercise program;Exercise Test;Exercise Tolerance;exercise training;feeding;Fine needle aspiration biopsy;flexibility;Food;Food production;Goals;Gynecologic;Health Personnel;Health Services Research;Hematologic Neoplasms;Human;Human Resources;improved;Indirect Calorimetry;Individual;Intake;interest;Intervention;Intervention Studies;Knowledge;Laboratories;Life Style;Life Style Modification;Malignant Breast Neoplasm;Malignant neoplasm of ovary;Malignant neoplasm of prostate;Malignant Neoplasms;Measurement;minimally invasive;Monitor;nutrition;Nutritional;Nutritional Study;Nutritional Support;Obesity;Participant;Physical activity;Postdoctoral Fellow;Preventable cancer cause;Prevention;Privacy;Procedures;Prognosis;programs;Protocols documentation;Quality of life;Research;research facility;Research Personnel;research study;Resource Sharing;Resources;Science;Services;Specimen;Specimen Handling;Spirometry;Students;survivorship;Testing;Training;tumor immunology;VO2max

PROJECT_TITLE: Shared Resource: Prevention Center


PI_NAMEs: COOPER, JONATHAN A (contact)

PROJECT_TERMS: Adopted;Affinity;Animal Model;Area;Basic Science;Belief;biological research;Biology;Biomedical Engineering;Brain;Cancer Biology;cancer cell;Cancer Center Support Grant;Cancer Detection;cancer diagnosis;Cancer Etiology;cancer genomics;cancer therapy;cancer type;Catchment Area;cell behavior;Cell Cycle;cell free DNA;cell motility;Cell Separation;Cells;Cellular biology;Center Core Grants;Child;Chromatin Structure;Chromosome Segregation;Clinical;Clinical Research;Collaborations;Computational Biology;Data;Development;Direct Costs;Disease;DNA analysis;DNA Repair;Engineering;Epigenetic Process;epigenomics;Faculty;forging;Fostering;Foundations;fundamental research;Funding;Gene Expression;Gene Expression Profile;Genome;Genomics;Goals;graduate student;Grant;high throughput screening;Image;improved;Incentives;inhibitor;innovation;Institution;Knowledge;Laboratories;Leadership;Learning;Lung;Malignant neoplasm of brain;Malignant neoplasm of lung;Malignant Neoplasms;meetings;member;Mentors;Methods;Microfluidics;Mission;Monitor;Morbidity - disease rate;mortality;Mutagenesis;nanomolar;Nature;next generation;Normal Cell;nuclease;Organ;Outcome;Paper;Peer Review;Phenotype;Play;Population;Postdoctoral Fellow;pre-clinical;preclinical study;Preparation;Productivity;programs;Protein Chemistry;Protein Engineering;protein structure prediction;Proteins;Publications;Publishing;recruit;Recruitment Activity;Research;Research Design;Research Personnel;Research Project Grants;Research Support;Resource Sharing;Resources;RNA;Role;Sampling;Science;Scientist;Signal Transduction;Site;Specific qualifier value;stem cells;structural biology;Structure;Subgroup;Techniques;Technology;three dimensional structure;Tissues;tool;Training;Training Programs;transcriptome;translational potential;Translational Research;translational study;Universities;variant of unknown significance;Washington;Work

PROJECT_TITLE: Research Program: Cancer Basic Biology


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Relevance Physician-scientists are crucial for translating laboratory discoveries into improvements in patient care. As advances in biomedical research continue to expand our understanding of human biology, it is critical to maintain a strong cadre of physician-scientists who will be able to apply this new knowledge to improve health outcomes. The Vanderbilt Training of Otolaryngology Physician-Scientists (V-TOPS) program will develop physician- scientists in otolaryngology, preparing trainees to become independent investigators and leaders in the field.

PI_NAMEs: GELBARD, ALEXANDER  (contact)

PROGRAM_OFFICER_NAME: RIVERA-RENTAS, ALBERTO L

PROJECT_TERMS: Address;Area;Basic Science;Biomedical Research;career;Career Choice;Characteristics;Clinical;Cochlear Implants;cohort;Complex;Development;Disease;education research;Educational Curriculum;effectiveness evaluation;Environment;experience;Faculty;faculty mentor;Feedback;Financial Hardship;Foundations;Functional disorder;Funding;Future;Goals;Head and neck structure;Head and Neck Surgery;Health;Human Biology;Immunology;improved;Individual;Inflammation;interest;Journals;Knowledge;Laboratories;Language Disorders;Larynx;Life;matriculation;Medical;medical schools;Medical Students;Mentors;Mentorship;Methods;minority trainee;Modification;next generation;novel strategies;Oncology;Otolaryngology;Outcome;outreach;Patient Care;Patients;Physicians;Physiology;Positioning Attribute;programs;Publishing;Recording of previous events;recruit;Research;Research Personnel;Research Project Grants;Research Support;Research Training;Residencies;science education;Scientist;Second Look Surgery;Side;skills;Smell Perception;Students;success;Time;Training;Training Programs;Translating;translational scientist;trend;Underrepresented Minority;United States National Institutes of Health;web page;Woman

PROJECT_TITLE: Vanderbilt Training of Otolaryngology Physician Scientists (V-TOPS) Program


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Cancer Genomics;Clinical Research;Cost Effectiveness Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Human Genome;Nutrition;Obesity;Prevention;Social Determinants of Health

PI_NAMEs: MALONE, KATHLEEN E (contact)

PROJECT_TERMS: administrative database;Affect;Appointment;Area;Behavioral;Behavioral Sciences;biobank;Biometry;Cancer Burden;cancer care;Cancer Center Support Grant;Cancer Control;cancer epidemiology;Cancer Etiology;cancer prevention;cancer risk;care delivery;Catchment Area;Center Core Grants;Child;Clinical;clinical practice;cohort;Collaborations;Communities;community intervention;comorbidity;Cost Effectiveness Analysis;Data;Development;Direct Costs;Discipline;Disease;dissemination science;Early Diagnosis;Economics;Endogenous Factors;Environmental and Occupational Exposure;Epidemiology;Etiology;Evaluation;Faculty;Funding;General Population;Generations;Genetic;Genome;Genomics;Goals;Grant;Health;health determinants;health economics;Health Policy;Health Promotion;Health Services;high risk population;Home;implementation science;improved;Incidence;Individual;Inequity;Integrated Health Care Systems;Intervention;Knowledge;Laboratories;Leadership;Life Style;Malignant Neoplasms;Medical Oncology;meetings;member;metabolome;Methodology;Methods;microbiome;Mission;Morbidity - disease rate;mortality;Neoplasm Metastasis;neoplasm registry;new technology;next generation;novel;novel strategies;nutrition;Obesity;obesity prevention;Observational Study;Outcome;Outcomes Research;Paper;Peer Review;Pharmaceutical Preparations;Physical activity;Play;Population;Population Sciences;Prevention;Prevention strategy;Prevention trial;Productivity;Prognosis;programs;Proteome;Psychology;Publishing;Quality of life;Randomized, Controlled Trials;Recording of previous events;recruit;Recurrence;Registries;Research;Research Design;Research Personnel;Research Project Grants;Resource Sharing;Resources;risk prediction model;Risk Reduction;risk stratification;Role;screening;Screening for cancer;Second Primary Cancers;shift work;smoking cessation;Special Population;Surveillance Methods;survivorship;System;Target Populations;Testing;Training;Translating;Treatment Failure;Underserved Population;Universities;uptake;Washington;Work

PROJECT_TITLE: Research Program: Cancer Epidemiology, Prevention & Control


ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

NIH_SPENDING_CATS: Genetics;Hematology;Kidney Disease

ORG_CITY: BIRMINGHAM

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Project Narrative Chronic kidney disease (CKD) is a significant public health challenge and a substantial cause of mortality, morbidity, and health care expenditure. The goal of this project is to decipher how dysregulated iron metabolism, a hallmark of CKD, may impact the course and progression of CKD. The studies will focus on ferritin, a key iron storage protein, in the macrophages and will examine the exciting novel approach of targeting macrophage ferritin expression to diminish CKD.

PI_NAMEs: ZARJOU, ABOLFAZL  (contact)

PROGRAM_OFFICER_NAME: ROY, CINDY

PROJECT_TERMS: Address;Affect;alpha synuclein;American;Anemia;Area;Biopsy;Cells;Chronic Kidney Failure;Clinical;Creatinine;Data;Death Rate;Deposition;Development;Disease;disease model;Equilibrium;experimental study;feasibility testing;Ferritin;Fibrosis;Foundations;Goals;Health;Health Expenditures;health plan;Homeostasis;Individual;Inflammation;Inflammatory;Injury;Injury to Kidney;Iron;Iron binding capacity measurement;iron deficiency;iron metabolism;Iron Overload;Kidney;Knowledge;Laboratories;Leukocytes;Light;Macrophage;Maintenance;Modeling;Molecular;monocyte;Morbidity - disease rate;mortality;Mus;Myelogenous;Myeloid Cells;nephrogenesis;Nerve Degeneration;new therapeutic target;novel strategies;novel therapeutic intervention;Outcome;overexpression;Pathogenesis;Pathogenicity;Pathway interactions;Persons;Phenotype;Process;Proteins;Public Health;Recycling;Regulation;Renal function;Renal Replacement Therapy;repaired;Reporter;Resolution;response;response to injury;Role;Serum;single-cell RNA sequencing;Source;Techniques;Testing;trafficking;transcription factor;Transcriptional Regulation;transcriptome sequencing;transcriptomics;Transgenic Mice;Tubular formation;United States Dept. of Health and Human Services;Up-Regulation;urinary;Work

PROJECT_TITLE: Regulation of Macrophage Phenotype by Ferritin Heavy Chain in CKD

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Diabetes

ORG_CITY: CHAPEL HILL

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Narrative LPL is the enzyme that clears lipids from the blood, and ensuring optimal LPL levels and activity are important to preventing heart disease. After it is made, LPL must be folded into its active form and stored within cells until insulin signals it to move out of the cells. Here, we will study the mechanisms that ensure LPL has efficient transit through cells so it can reach the blood.

PI_NAMEs: NEHER, SASKIA  (contact)

PROGRAM_OFFICER_NAME: LIU, LIJUAN

PROJECT_TERMS: Adipocytes;Adipose tissue;ADP-Ribosylation Factors;Affect;Biology;Blood;blood lipid;Cause of Death;Caveolins;Cell Line;Cell secretion;Cell surface;cell type;Cells;Cellular biology;Circulation;Complement;Cryoelectron Microscopy;Defect;Diabetes Mellitus;diabetic;dimer;disulfide bond;Endoplasmic Reticulum;Ensure;Environment;Enzymes;experimental study;Glucose Transporter;GLUT 4 protein;Golgi Apparatus;heart disease prevention;heart disease risk;Heart Diseases;high risk;Homeostasis;Hormones;Hypertriglyceridemia;Individual;inhibitor;Insulin;Insulin Resistance;insulin signaling;Intervention;Leptin;Link;Lipase;Lipids;lipoprotein lipase;Lipoproteins;Membrane Proteins;Microscopy;Modeling;Movement;non-diabetic;Outcome;Oxidation-Reduction;Pathway interactions;Plasma;Polysaccharides;preservation;Process;Protein Biochemistry;protein kinase D;Proteins;Proteomics;Quality Control;response;Risk Factors;Role;Secretory Vesicles;Signal Transduction;Sorting;Structure;System;trafficking;Triglycerides;Type 2 diabetic;Vesicle;Work

PROJECT_TITLE: Lipoprotein Lipase Through the Secretory System

STUDY_SECTION: NMHD

STUDY_SECTION_NAME: Nutrition and Metabolism in Health and Disease Study Section[NMHD]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Digestive Diseases;Emerging Infectious Diseases;Genetics;Hematology;Hepatitis;Hepatitis - B;Human Genome;Infectious Diseases;Liver Disease;Lymphatic Research;Lymphoma;Prevention;Rare Diseases;Skin Cancer

PI_NAMEs: GALLOWAY, DENISE A. (contact)

PROJECT_TERMS: Abbreviations;Address;Affect;Anogenital cancer;anti-cancer research;Appointment;B-cell receptor repertoire sequencing;Back;Bacteria;Biology;Burkitt Lymphoma;Cancer Biology;Cancer Burden;Cancer Center Support Grant;Cancer Etiology;carcinogenesis;Carcinoma;Center Core Grants;Child;chimeric antigen receptor T cells;Clinical;clinical translation;Collaborations;Computational Biology;Country;design;Development;Diagnosis;Direct Costs;engineered T cells;Epidemiologist;Epidemiology;Faculty;Funding;Genitalia;Grant;Helicobacter pylori;Helicobacter pylori induced gastric cancer;Hepatitis B Virus;Hepatitis C virus;Hepatitis Viruses;Human Herpesvirus 4;Human Herpesvirus 8;Human papilloma virus infection;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;Immunology;improved;inter-institutional;Kaposi Sarcoma;low income country;Lymphoma;Malignant neoplasm of liver;Malignant Neoplasms;malignant oropharynx neoplasm;Measures;meetings;member;Merkel cell carcinoma;Merkel Cells;microbiome;Modality;Modeling;Natural History;novel;Oncology;oncology program;Paper;pathogen;Peer Review;Play;Polyomavirus;pre-clinical;prevent;Prevention;Prevention strategy;programs;Public Health;Publishing;recruit;Research;Research Personnel;Research Project Grants;Research Support;Resource Sharing;Resources;Role;single-cell RNA sequencing;Study models;T cell receptor repertoire sequencing;T-Cell Receptor;Therapeutic;translational study;treatment guidelines;treatment response;treatment strategy;tumor immunology;Universities;vaccine acceptance;vaccine development;Virus;virus development;Virus-like particle;Washington;Work

PROJECT_TITLE: Research Program: Pathogen Associated Malignancies


NIH_SPENDING_CATS: Biotechnology;Cancer;Hematology;Immunization;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

PI_NAMEs: APPELBAUM, FREDERICK  (contact)

PROJECT_TERMS: Achievement;Animal Model;antibody engineering;Antibody Therapy;Antibody-drug conjugates;Architecture;Bioinformatics;Biological;Biology;Biostatistics Shared Resource;Bone Marrow Transplantation;Cancer Center Support Grant;cell community;Cell model;Cells;Center Core Grants;Child;Collaborations;comparative;CRISPR/Cas technology;curative treatments;Defect;Development;Diagnosis;digital;Dimensions;Direct Costs;Disease;effective therapy;Emerging Technologies;Faculty;Fanconi's Anemia;Flow Cytometry;Funding;Gene Expression Profiling;gene therapy;Genes;Genetic Engineering;Genomics;Grant;Hematologic Neoplasms;Hematopoiesis;Hematopoietic;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;Immune system;Immunocompetent;Immunologic Monitoring;improved;Individual;induced pluripotent stem cell;insight;Intervention;Knowledge;Laboratories;laboratory development;leukemia;Malignant Neoplasms;manufacture;Medicine;meetings;member;Methods;Modeling;Monitor;Morbidity - disease rate;mortality;Mutation;Mutation Analysis;new technology;novel strategies;Paper;Pathology;Patients;Peer Review;Phenotype;programs;Publishing;Radioimmunotherapy;recruit;Research;Research Project Grants;Research Support;Resource Sharing;Resources;Safety;Speed;stem cell biology;stem cell function;T-Lymphocyte;Technology;Therapeutic;Translating;Transplantation;Universities;Virus Diseases;Washington;Work

PROJECT_TITLE: Research Program: Hematologic Malignancies


NIH_SPENDING_CATS: Aging;Clinical Research;Clinical Trials and Supportive Activities;Infectious Diseases;Urologic Diseases;Women's Health Research

ORG_CITY: Pittsburgh

ORG_NAME: MAGEE-WOMEN'S RES INST AND FOUNDATION

ORG_STATE: PA

PHR: PROJECT NARRATIVE Recurrent urinary tract infections (rUTI) are especially common in older women, but our understanding of the natural progression of UTIs in this population is limited by inadequate inclusion in previous randomized trials. High quality, prospective data demonstrating the safety and acceptability of a culture-directed UTI treatment strategy is required to drive change in current clinical practice of prescribing empiric antibiotics for UTI symptoms in older women. Our initial pilot randomized trial of a culture-directed versus empiric antibiotic strategy for patient reported UTI in older women with rUTI is the first step towards attainment of key information for shared decision making to improve outpatient antibiotic stewardship in this population.

PI_NAMEs: BRADLEY, MEGAN  (contact)

PROGRAM_OFFICER_NAME: REYNOLDS, WILLIAM STUART

PROJECT_TERMS: Acute;Acute Cystitis;Address;Adherence;Adoption;Adverse event;Affect;Age;Antibiotic Therapy;Antibiotics;antimicrobial;arm;Bacterial Antibiotic Resistance;Bacterial Infections;Bacteriuria;Bladder;care seeking;Characteristics;Chronic;Clinical;clinical practice;Clinical Sciences;Clinical Trials;Cohort Studies;Communication;Communities;Consultations;Data;design;Diagnosis;Disease Progression;Disproportionately impacts women;Electronics;Eligibility Determination;eligible participant;Enrollment;Ensure;Evaluation;experience;Feasibility Studies;Focus Groups;follow-up;Funding;Future;Gender;Guidelines;Health;High Prevalence;Hour;human old age (65+);improved;Individual;Infrastructure;insight;Interview;kidney infection;Knowledge;Laboratories;lower urinary tract symptoms;member;Methods;Morbidity - disease rate;novel;older women;Outcome;Outpatients;Patient Compliance;Patients;Pelvis;Persons;Pilot Projects;pilot trial;Population;Prevalence;Probability;Procedures;prospective;Protocols documentation;Provider;Questionnaires;Randomized;randomized trial;Randomized, Controlled Trials;Recording of previous events;recruit;Recurrence;Registries;Reporting;Research;Resistance;Resolution;Safety;secondary outcome;Sepsis;shared decision making;side effect;Structure;Surveys;Symptom Burden;Symptoms;Telephone;Time;Translational Research;treatment strategy;trial comparing;trial design;trial planning;Universities;Urinalysis;Urinary tract infection;Urine;Uropathogen;Voice;Woman;young woman

PROJECT_TITLE: A Randomized Pilot and Feasibility Study of a cultuRE-Directed approach to Urinary traCT Infection symptoms in older womeN: a mixed methods evaluation - the REDUCTION trial

STUDY_SECTION: ICSC

STUDY_SECTION_NAME: Interdisciplinary Clinical Care in Specialty Care Settings Study Section[ICSC]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Congenital Structural Anomalies;Diabetes;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period

ORG_CITY: BALTIMORE

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: PROJECT NARRATIVE Pregestational diabetes specifically impacts neurulation leading to neural tube defects, the second most common structural birth defects in human. This project will determine the crosstalk between the mTOR- p70S6K1 signaling and the HIPPO kinase Lats1 in the inhibition of the tissue organizer Yap and failed neurulation. The study will provide new mechanistic insights and therapeutic targets for diabetic embryopathy.

PI_NAMEs: SHEN, WEI-BIN ;YANG, PEIXIN  (contact)

PROGRAM_OFFICER_NAME: KOSTER, MARANKE IRENE

PROJECT_TERMS: Age;American;Amino Acids;antagonist;Apoptosis;Body Size;Cell Count;Cell Differentiation process;cell growth;Cell membrane;Cell Physiology;Cell Proliferation;Cell Size;Cells;Child;Complex;conditional knockout;Congenital Abnormality;constitutive expression;Data;Defect;Development;Diabetes Mellitus;diabetic;diabetic embryopathy;Embryo;Endoplasmic Reticulum;endoplasmic reticulum stress;Exposure to;FRAP1 gene;Functional disorder;Gene Expression;Gene Proteins;glycemic control;Growth;Homeostasis;Human;Hyperglycemia;Hypertrophy;Impairment;Induction of Apoptosis;inhibitor;insight;Intervention;Knockout Mice;LATS1 gene;malformation;maternal diabetes;Neural Tube Closure;Neural Tube Defects;Neuroepithelial Cells;neuroepithelium;Neurofibromin 2;neurogenesis;offspring;Organ Size;overexpression;Pathogenesis;Pathway interactions;Phosphorylation;Phosphorylation Site;Phosphotransferases;planar cell polarity;Prenatal care;prevent;Process;Proliferating;Proteins;Publishing;reproductive;Residual state;restoration;Scaffolding Protein;Signal Induction;Signal Transduction;Sirolimus;Site;Structural Congenital Anomalies;Testing;therapeutic target;Tissues;Transcription Coactivator;Transgenic Mice;Transgenic Organisms;Translations;upstream kinase;Woman

PROJECT_TITLE: Intersection of the mTOR/p70S6K1 signaling and the HIPPO-Yap tissue organizer in neurulation and diabetic embryopathy

STUDY_SECTION: PN

STUDY_SECTION_NAME: Pregnancy and Neonatology Study Section[PN]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Childhood Leukemia;Gene Therapy;Genetics;Hematology;Immunotherapy;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

PI_NAMEs: BLEAKLEY, MARIE  (contact)

PROJECT_TERMS: Adoptive Immunotherapy;Adult;Antibodies;Antigen Targeting;Appointment;Blood;cancer cell;Cancer Center Support Grant;cancer immunotherapy;Cell Physiology;Cell surface;Cell Therapy;Cells;Cellular immunotherapy;Center Core Grants;Child;chimeric antigen receptor;Clinical;clinical application;clinical infrastructure;Clinical Trials;Complex;Coupled;design;Development;Direct Costs;Down-Regulation;effector T cell;engineered T cells;Engineering;Evaluation;Faculty;first-in-human;Funding;Genetic Engineering;genetic manipulation;Grant;Hematologic Neoplasms;Hematopoietic Stem Cell Transplantation;humanized mouse;Immune;immune checkpoint blockade;Immune Evasion;Immune system;Immunity;Immunologics;Immunology;Immunotherapeutic agent;Immunotherapy;improved;insight;Institution;Investigation;Investments;Malignant Childhood Neoplasm;Malignant Neoplasms;Mediating;meetings;member;Metabolic;Modality;Modeling;Myelogenous;Nanotechnology;Nature;Neoplasm Metastasis;neoplastic cell;next generation;novel;Paper;Patients;Pediatric Hematology;Peer Review;Peptide/MHC Complex;pre-clinical;Pre-Clinical Model;programs;Property;Publishing;receptor;recruit;Regulatory T-Lymphocyte;Research;Research Infrastructure;Research Personnel;Research Project Grants;Research Support;Resistance;Resource Sharing;Resources;response;Role;Safety;Sampling;Science;Signal Transduction;small molecule;Solid Neoplasm;Specimen;success;synthetic biology;T cell therapy;T-Cell Receptor;T-Lymphocyte;Therapeutic;therapeutically effective;Translating;Transplantation;tumor;tumor eradication;tumor immunology;Tumor Tissue;Turtles;Universities;vaccine strategy;Washington;Work

PROJECT_TITLE: Research Program: Cancer Immunology


PI_NAMEs: NELSON, PETER S (contact)

PROJECT_TERMS: advanced prostate cancer;Androgen Receptor;Appointment;Behavior;Bioinformatics;cancer care;Cancer Center Support Grant;Clinic;clinical practice;Clinical Trials;comparative;Confusion;cost;Critical Pathways;Detection;Development;Diagnosis;Direct Costs;Disease;Early Diagnosis;Effectiveness;Effectiveness of Interventions;effectiveness testing;Emotional;Environmental Risk Factor;Evolution;Exhibits;Faculty;Financial cost;Funding;Genomics;Goals;Grant;Healthcare Systems;Heritability;high risk;Immunotherapeutic agent;improved;Indolent;Intervention;Knowledge;Malignant neoplasm of prostate;Malignant Neoplasms;Measures;Medicine;meetings;member;men;Metastatic Prostate Cancer;Methods;Molecular;Morbidity - disease rate;mortality;novel therapeutic intervention;Oncogenic;overtreatment;Paper;Pathology;Patients;Peer Review;Phenotype;Pre-Clinical Model;prevent;Prevention;Productivity;programs;prostate cancer risk;Prostate Cancer therapy;Prostate carcinoma;Protocols documentation;Publishing;Quality of life;rational design;Receptor Signaling;recruit;refractory cancer;Research;Research Project Grants;Research Support;Resistance;resistance mechanism;Resource Sharing;response;Risk;Risk Assessment;Scientific Advances and Accomplishments;screening;Shapes;side effect;Site;Societies;sound;System;Testing;Therapeutic;Time;time interval;Treatment Side Effects;tumor;tumor microenvironment;United States;United States Department of Veterans Affairs;Universities;Variant;Washington;Work

PROJECT_TITLE: Research Program: Prostate Cancer


NIH_SPENDING_CATS: Aging;Breast Cancer;Cancer;Genetics;Orphan Drug;Ovarian Cancer;Prevention;Rare Diseases;Women's Health Research

PI_NAMEs: SWISHER, ELIZABETH MARY (contact)

PROJECT_TERMS: BRCA1 gene;BRCA2 gene;Breast;Breast Cancer Prevention;Breast Cancer survivor;Breast Cancer therapy;cancer care;Cancer Center Support Grant;cancer prevention;cancer type;Catchment Area;Center Core Grants;Clinical;cognitive rehabilitation;Communities;Dedications;Defect;Derivation procedure;Detection;Diagnosis;Direct Costs;Disease;DNA;DNA Repair;Early Diagnosis;ERBB2 gene;Exercise;Faculty;Fostering;Funding;Genetic Predisposition to Disease;Genetic Risk;Grant;high risk;Histologic;homologous recombination;Hormonal;hormone receptor-negative;improved;Incidence;Institution;Interdisciplinary Study;Intervention;Ionizing radiation;Localized Malignant Neoplasm;Malignant Breast Neoplasm;Malignant neoplasm of ovary;Malignant Neoplasms;Mammalian Oviducts;meetings;member;Mismatch Repair;Molecular;molecular subtypes;mortality;Mutation;Oncogenes;Ovary;overexpression;Paper;Peer Review;Peritoneum;PIK3CA gene;Platinum Compounds;Poly(ADP-ribose) Polymerase Inhibitor;Population;Predisposition;programs;Publishing;rare cancer;recruit;Reproductive Behavior;Research;Research Personnel;Research Project Grants;Research Support;Resistance;Resource Sharing;Resources;response;Risk;Risk Assessment;Secondary to;Serous;stress reduction;Survivors;survivorship;targeted treatment;Therapeutic;therapeutic target;Tissues;triple-negative invasive breast carcinoma;Universities;Washington;Woman;Women's mortality;Work

PROJECT_TITLE: Research Program: Breast & Ovary Cancers


NIH_SPENDING_CATS: Neurosciences

ORG_CITY: IOWA CITY

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Project Narrative (3 sentences) This doctoral readiness program, Iowa Diversifying Research Experiences And Mentorship (iDREAM), capitalizes on an outstanding T32 supported (JSPTPN) Neuroscience Graduate program with a highly successful track record of training neuroscientists from diverse backgrounds, particularly those from backgrounds underrepresented in STEM. It integrates an outstanding interdisciplinary neuroscience research environment with evidence-based practices designed to cultivate self-efficacy and a strong sense of belonging within the local and global neuroscience research communities. In doing so, iDREAM is designed to provide high quality research experiences and didactics to post-baccalaureate students from institutions that do not offer undergraduates substantial research opportunities, ultimately empowering trainees to be competitive for and successful in rigorous, top-tier neuroscience graduate programs and beyond.

PI_NAMEs: HULTMAN, RAINBO  (contact);TRANEL, DANIEL T.;VOSS, MICHELLE WEBB

PROJECT_TERMS: Admission activity;Applications Grants;Area;Awareness;career;career development;Climate;Communication;Communities;Critical Thinking;Data;design;Development;diversity and inclusion;Doctor of Philosophy;education research;Educational workshop;Elevator;empowerment;Ensure;Environment;equity, diversity, and inclusion;essays;evidence base;Evidence based practice;expectation;experience;Faculty;faculty research;Funding;Future;Gender;Goals;graduate school;hands on research;Healthcare;innovation;Institution;interest;Interview;Iowa;Laboratories;Laboratory Research;Lead;Leadership;matriculation;meetings;member;Mentors;Mentorship;Methodology;Mission;Neurosciences;Neurosciences Research;Paper;Parents;Participant;peer;Persons;Positioning Attribute;Postbaccalaureate;Process;programs;Qualifying;Readiness;recruit;Reporting;Research;Research Project Grants;response;responsible research conduct;Running;Schools;Self Efficacy;skills;Structure;Students;success;Talents;Teacher Professional Development;tenure track;Training;Training Programs;undergraduate student;underrepresented minority student;Underrepresented Students;Universities;university student;verbal;Vision;Writing

PROJECT_TITLE: Iowa-Diversifying Research And Mentorship (iDREAM)


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Colorectal Cancer;Data Science;Digestive Diseases;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Precision Medicine;Prevention

PI_NAMEs: KOOPERBERG, CHARLES L (contact)

PROJECT_TERMS: Address;Adopted;anti-cancer research;Area;Bioinformatics;Biological;biological research;Biology;biomarker discovery;biomedical data science;Biomedical Research;Biometry;Cancer Burden;Cancer Center Support Grant;cancer diagnosis;cancer genomics;Clinical Trials;Collaborations;colorectal cancer screening;Communicable Diseases;Companions;Computational Biology;computational platform;computer science;Computing Methodologies;Data;Data Analyses;Data Science;Data Set;design;Development;diagnostic biomarker;diagnostic tool;Educational Status;Environment;Environmental Exposure;Evaluation;experimental study;Funding;Future;genome analysis;genome-wide;Growth;Growth and Development function;handheld mobile device;Health;high throughput technology;Human;Immune;Immune response;Immunotherapy;Informatics;Institution;International;Knowledge;Leadership;leukemia treatment;Life Style;Machine Learning;Malignant neoplasm of prostate;Malignant Neoplasms;mathematical methods;Mathematics;Measures;Medicine;member;method development;Methodology;Methods;microbiome;Mission;Molecular Biology;molecular diagnostics;multidimensional data;Natural History;novel;novel diagnostics;novel therapeutics;Penetration;personalized approach;personalized medicine;Positioning Attribute;precision medicine;precision oncology;predictive marker;Prevention;Productivity;programs;Publications;recruit;Reproducibility;Research;Research Methodology;Research Personnel;Research Project Grants;response;risk stratification;RNA Processing;Science;Software Tools;Statistical Methods;statistics;Technology;Therapeutic;Therapeutic Trials;Training;Translating;tumor;Work

PROJECT_TITLE: Research Program: Biostatistics & Computational Biology


NIH_SPENDING_CATS: Bioengineering;Contraception/Reproduction;Genetics;Human Genome;Maternal Health;Nanotechnology;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Women's Health Research

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: PROJECT NARRATIVE Preterm birth (PTB) is a leading cause of infant morbidity and mortality, and yet very few options are available for identifying and treating women at risk of PTB. Herein, we propose studies that build from exciting preliminary data using nanomedicine to probe fundamental questions regarding the role of epigenetic regulation in inflammation-induced PTB. If successful, we will generate fundamental mechanistic knowledge of epigenetic regulation in inflammation-induced PTB, as well as identify new cellular pathways that may be important targets for PTB prevention.

PI_NAMEs: BURD, IRINA ;ENSIGN, LAURA  (contact)

PROGRAM_OFFICER_NAME: GIRARDI, GUILLERMINA

PROJECT_TERMS: 37 weeks gestation;Address;Affect;Animals;Anti-Inflammatory Agents;Biological Process;Birth;Brain;Caproates;Cell Culture Techniques;Cells;Cervical;Cervical Ripening;Cervix Uteri;Chromatin;Chromatin Structure;Clinical;Clinical Trials;Competence;Complex;Data;Development;Dose;E1A-associated p300 protein;effective therapy;Environment;EP300 gene;Epigenetic Process;epigenetic regulation;epigenome;Etiology;Exhibits;Failure;Family;fetal;Fetal Development;Formulation;Gel;Gene Expression;Gene Expression Profile;Genes;Genetic Transcription;genome-wide;Genomics;Goals;High Risk Woman;Histone Deacetylase Inhibitor;Histone Deacetylation;histone modification;Histones;Human;Hydroxyprogesterone;Impaired cognition;in utero;In Vitro;Infant Care;infant morbidity;infant morbidity/mortality;Infant Mortality;Inflammation;innovation;intrauterine inflammation;Knockout Mice;Knowledge;Ligand Binding;Lung;lung development;Maps;Marketing;Maternal-Fetal Exchange;Mediating;Modeling;Motor;mouse model;Mus;Myometrial;myometrium;nano;nanoengineering;nanoformulation;nanomedicine;neonate;Neurologic;novel;Nuclear Receptors;Pathway interactions;Placenta;post-market;preclinical study;Pregnancy;pregnant;premature;Premature Birth;preservation;prevent;Prevention;Prevention therapy;Progesterone;progesterone receptor B;Progesterone Receptors;Protein Isoforms;pup;receptor;Recommendation;reproductive tract;Role;Signal Pathway;Structure;Suspensions;Synthetic Progestogens;Testing;Therapeutic;tissue culture;Tissue Sample;Tissues;tool;transcription factor;transcriptome sequencing;treatment effect;Trichostatin A;Uterus;Vagina;Vaginal delivery procedure;Vorinostat;women's treatment

PROJECT_TITLE: Nanomedicine-based approach for characterizing the epigenome in prevention of inflammation-induced preterm birth.


NIH_SPENDING_CATS: American Indian or Alaska Native;Burden of Illness;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: MENDOZA, JASON A (contact)

PROJECT_TERMS: Address;Alaska Native;American Indians;anti-cancer research;Area;Biology;Black Populations;Breast;Cancer Burden;cancer care;Cancer Center Support Grant;Cancer Control;cancer prevention;cancer site;Catchment Area;Child;Collaborations;Colorectal;Communities;Community Actions;community engagement;Community Health;community organizations;Community Outreach;County;Diagnostic;Disease;Education;Equity;ethnic minority;Ethnic Origin;evidence base;Funding;Geography;Goals;Grant;Health Disparities Research;Health Educators;health equity;Hematologic Neoplasms;Hispanic Populations;Incidence;Individual;Inequity;insight;Latino Population;Leadership;Link;Lung;Malignant Neoplasms;meetings;member;Mission;Monitor;mortality;Needs Assessment;Not Hispanic or Latino;outreach;patient navigation;Persons;Population;population based;Prevention;Process;Process Assessment;programs;Prostate;Public Health;Race;racial minority;Registries;Research;Research Infrastructure;Research Personnel;residence;response;rural area;rural counties;rural dwellers;Rural Population;SEER Program;Site;Socioeconomic Status;success;System;Time;treatment trial;underserved area;Underserved Population;Universities;Washington;Work

PROJECT_TITLE: Community Outreach & Engagement


NIH_SPENDING_CATS: Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

PI_NAMEs: LYNCH, THOMAS JAMES (contact)

PROJECT_TERMS: Address;Area;Award;Biology;Cancer Center Support Grant;cancer health disparity;Cancer Research Project;Catchment Area;Child;Collaborations;community engagement;Community Outreach;Data;Development;disparity reduction;Emerging Technologies;Faculty;Funding;Future;Grant;Growth;Health Disparities Research;Health Service Area;Human Resources;Individual;innovation;Institution;Laboratories;Lead;Malignant Neoplasms;member;Modeling;mouse model;new technology;Outcomes Research;pathogen;Pilot Projects;Pre-Clinical Model;Productivity;Publications;recruit;Research;Research Personnel;Research Support;Resource Development;Resource Sharing;Resources;Risk Reduction;Science;Solid Neoplasm;Special Population;Technology;Translational Research;tumor immunology;Underserved Population;Universities;Washington

PROJECT_TITLE: Development Funds


PROJECT_TITLE: Leadership, Planning and Evaluation


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Patient Safety;Pediatric;Pediatric Cancer;Racial and Ethnic Minority Health Research;Rare Diseases

PI_NAMEs: YU, EVAN  (contact)

PROJECT_TERMS: Active Learning;anti-cancer research;Cancer Center Support Grant;Catchment Area;Child;Clinical Data;Clinical Management;Clinical Protocols;Clinical Research;Clinical Trials;clinically relevant;Communication;community engagement;Community Outreach;Data;data integrity;data management;demographics;Diagnosis;Enrollment;Ensure;Ethnic Origin;Fostering;Good Clinical Practice;Growth;Hispanic;Hispanic Populations;improved;Individual;Infrastructure;Institution;Intervention;Intervention Studies;Intervention Trial;Malignant Neoplasms;member;Minority;Minority Health Research;Monitor;National Clinical Trials Network;oncology trial;participant enrollment;patient population;patient safety;Pediatric Oncology;Pediatric Oncology Group;pediatric patients;Peer Review;Policies;Population;Process;Progress Reports;Protocol Compliance;protocol development;Publications;quality assurance;Quality Control;racial minority;real time monitoring;recruit;Reporting;repository;Research;Research Infrastructure;Research Personnel;research study;Research Support;Risk;Rural Community;Safety;System;Training and Education;treatment trial;trial comparing;Trust;Underserved Population;United States National Institutes of Health;Universities;Washington;Woman

PROJECT_TITLE: Clinical Protocol and Data Management


ADMINISTERING_IC: AR

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Biotechnology;Genetics;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human

ORG_CITY: CAMBRIDGE

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: HARVARD UNIVERSITY

PHR: Project Narrative The proposed research will build tools that enables the research community to test gene function in diverse dermal cell types in mice directly. The results will also identify novel regulators of hair follicle stem cell activity and maintenance. These results are not only important for fundamental understanding of stem cell biology, but may also inform innovative therapeutic solutions related to conditions such as hair loss.

PI_NAMEs: HSU, YA-CHIEH  (contact)

PROGRAM_OFFICER_NAME: BELKIN, ALEXEY

PROJECT_TERMS: Ablation;Acceleration;Address;Agonist;Alopecia;Automobile Driving;Behavior;Biological;Candidate Disease Gene;cell behavior;cell type;Cells;Chromatin;Communities;Data;Data Set;Dependovirus;Deposition;Dermal;Dermis;Development;Enhancers;Fibroblasts;Future;Gene Expression;gene function;gene therapy;Genes;Genetic;genetic manipulation;Genetic Models;genetic signature;genetic testing;glial cell-line derived neurotrophic factor;Goals;Hair;hair erector muscle;Hair follicle structure;Homeostasis;Immunofluorescence Immunologic;improved;in vivo;inhibitor;innovation;insight;Knockout Mice;Knowledge;LIF gene;Maintenance;Measures;Mediating;Mediator;Methods;Molecular;Molecular Profiling;Mus;Muscle;muscular system;Natural regeneration;Nerve;nerve supply;new technology;novel;novel strategies;novel therapeutics;Organ;overexpression;Physiological;Plasmids;Play;Population;Process;promoter;Publications;Regulatory Element;repaired;repository;Research;Research Personnel;Role;Serotyping;Signal Transduction;single cell ATAC-seq;single cell sequencing;single-cell RNA sequencing;Skin;skin disorder;Smooth Muscle;Specificity;stem cell biology;stem cell niche;stem cells;success;Testing;Therapeutic;therapy development;Time;Tissues;tongue papilla;tool;transcriptome sequencing;Tropism;Viral;Work;wound healing

PROJECT_TITLE: Rapid functional genetics to study stem cell-niche interactions in the skin

STUDY_SECTION: ACTS

STUDY_SECTION_NAME: Arthritis, Connective Tissue and Skin Study Section[ACTS]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision

ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative The corneal neovascularization is a potential sight-threatening condition caused by the growing of new blood vessels into the normally avascular tissues. Fibroblast growth factor 2 and membrane-type 1 matrix metalloproteinase are highly induced by injury and infection in cornea. We propose a novel function of MMP-14 in regulating fibroblast growth factor 2-downstream signaling, and selective MMP-14 inhibitors can be potential therapeutics against FGF2/FGFR2-mediated corneal neovascularization.

PI_NAMEs: HAN, KYUYEON  (contact)

PROGRAM_OFFICER_NAME: MCKIE, GEORGE ANN

PROJECT_TERMS: analog;Angiogenesis Inhibitors;Angiogenic Factor;Angiostatins;Animal Model;Antibodies;Binding;Biological Assay;Biophysics;Blindness;Blood Vessels;cell type;Cells;Cellular Infiltration;Clioquinol;conditional knockout;Cornea;Corneal Diseases;Corneal Injury;Corneal Neovascularization;cytokine;cytotoxicity;Effectiveness;Endostatins;Endothelial Cells;enzyme activity;Enzymes;Equilibrium;Event;experimental study;Extracellular Matrix;Extracellular Matrix Degradation;FDA approved;FGF2 gene;FGFR2 gene;Fibroblast Growth Factor;Fibroblasts;Folic Acid;Gelatinase A;Gelatinase B;Goals;immune cell infiltrate;Impairment;Implant;In Vitro;in vivo;Infection;Infiltration;Inflammation;Inflammatory;inhibitor;injured;Injury;innovation;KDR gene;Knock-out;Knockout Mice;Lead;Libraries;Macrophage;Matrix Metalloproteinase Inhibitor;Matrix Metalloproteinases;Measures;Mediating;membrane activity;MMP14 gene;Molecular Biology Techniques;Mus;mutant;Neutrophil Collagenase;novel;novel therapeutics;Pharmaceutical Preparations;pigment epithelium-derived factor;proMMP-2;protein expression;Proteins;Proteolysis;quinoline;quinoline analog;receptor;Regulation;Reporting;Role;scaffold;side effect;Signal Transduction;small molecule;small molecule inhibitor;Specificity;System;Testing;Therapeutic;Therapeutic Agents;Tissues;TNF-alpha converting enzyme;Validation;Vascular Endothelial Cell;Vascular Endothelial Growth Factor Receptor-1;Vascular Endothelial Growth Factors;VEGFA gene;Vision;Wild Type Mouse

PROJECT_TITLE: Identification of a new role of membrane‐type 1 matrix metalloproteinases in corneal neovascularization

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 1 Study Section[PED1]


NIH_SPENDING_CATS: Cancer;Patient Safety

PI_NAMEs: GOPAL, AJAY  (contact)

PROJECT_TERMS: authority;Biostatistics Shared Resource;Businesses;Calendar;Cancer Center Support Grant;cancer clinical trial;Clinical Data;Clinical Protocols;clinical trial protocol;Clinical Trials;data management;design;Development;Ensure;Exclusion;Human;Institution;Institutional Review Boards;Investments;Malignant Neoplasms;meetings;Mission;Monitor;operation;patient population;Policies;Process;Protocols documentation;Research;Resources;Review Committee;sound;Special Population;Structure;System;Time;Update

PROJECT_TITLE: Protocol Review and Monitoring System


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: ARLINGTON

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF TEXAS ARLINGTON

ORG_STATE: TX

PHR: PROJECT NARRATIVE (RELEVANCE) In this project, we seek to develop a novel quantum mechanics-based covalent drug docking approach enabling the determination of warhead-target reaction mechanisms and their kinetic and thermodynamics properties. The developed approach will overcome the limitation of existing drug docking programs by explicitly modeling chemical events and facilitate reliable and quick predictions of covalently docked poses and their reactivity profiles.

PI_NAMEs: NAM, KWANGHO  (contact)

PROGRAM_OFFICER_NAME: GERSHENSON, ANNE

PROJECT_TITLE: EnzyDock-based Multistate and Multiscale Tools for Covalent Drug Design


ORG_DEPT: GENETICS

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: PROJECT NARRATIVE  This project is to generate a collection of split-Gal4 lines that will be used to map the cell clusters characterized from scRNAseq studies to anatomy. Knowledge gained from these studies will also be used to generate a set of Gal4 reagents that will allow specific and inducible control of gene expression. The resources we build will contribute to the knowledge of Drosophila and help researchers develop Drosophila models of human diseases, and as such are relevant to almost all NIH institutes.

PI_NAMEs: PERRIMON, NORBERT  (contact)

PROGRAM_OFFICER_NAME: ZOU, SIGE

PROJECT_TERMS: Address;Adult;Algorithms;Anatomy;animal model development;Antibodies;Atlases;body map;Brain;cell type;Cells;Collection;Communities;cooking;Data;Data Analyses;Data Set;Detection;Development;differential expression;DNA Binding Domain;Drosophila genus;Engineering;Enhancers;experimental study;fly;Funding Opportunities;Gene Combinations;Gene Expression;Gene Expression Profile;Generations;Genes;Genetic Markers;Genomics;human disease;human model;In Situ Hybridization;Knowledge;Larva;Letters;Maps;Methods;Molecular Profiling;Nucleic Acid Regulatory Sequences;Organ;Output;Pattern;Phenotype;prevent;Proteins;Proxy;R24;Reagent;Reporter;Research Personnel;Research Project Grants;Resources;response;Sampling;single-cell RNA sequencing;Specificity;System;Technology;Testing;Time;Tissues;TNFSF5 gene;tool;Transcription Coactivator;Transgenes;United States National Institutes of Health;Validation;Visualization

PROJECT_TITLE: Resources for functional studies in Drosophila

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-GGG-A(55)R]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative An increase in the amount of a protein called lamin B1 in the brain occurs in a disease known as Autosomal Dominant Leukodystrophy (ADLD) causing loss of myelin (a fatty substance covering nerves) and leading to muscle wasting, weakness and early death. Why more of lamin B1, a protein expressed in many different tissues, specifically causes demyelination is unknown. This proposal aims to understand the mechanisms that cause the specificity by characterizing elements that regulate the expression of this gene both in cells and mouse models.

PI_NAMEs: PADIATH, QUASAR S (contact)

PROGRAM_OFFICER_NAME: MORRIS, JILL A

PROJECT_TERMS: Ablation;Adult;Age;Architecture;Astrocytes;Automobile Driving;Autopsy;autosome;Behavioral;Binding;Binding Sites;Bioinformatics;Biological Models;Biology;Brain;Brain region;brain tissue;CCCTC-binding factor;Cell Line;Cell Lineage;Cell model;cell type;Cells;Cessation of life;Chromatin;Complex;CRISPR/Cas technology;Data;Demyelinating Diseases;Demyelinations;Disease;Disease Pathway;disease phenotype;DNA Sequence Rearrangement;Elderly;Elements;Epigenetic Process;experimental study;Family;Fibroblasts;Gene Expression;Gene Silencing;Genes;Genetic Transcription;genomic locus;Genomic Segment;Genomics;Human;In Vitro;in vivo;Individual;insight;Lamin B1;Late-Onset Disorder;leukodystrophy;LMNB1 gene;Location;Maps;Mediating;member;Molecular;motor disorder;mouse model;Mus;Muscular Atrophy;Mutation;Myelin;Nerve;Nervous System Disorder;Neurons;novel;Nuclear;Nuclear Lamina;Nucleic Acid Regulatory Sequences;oligodendrocyte lineage;Oligodendroglia;overexpression;Pathway interactions;Patients;Phenotype;Play;Polycomb;Positioning Attribute;prevent;Proteins;recruit;Regulation;Regulatory Element;Role;segregation;Sequence Deletion;Specificity;Testing;Tissues;transcription factor;Transcriptional Silencer Elements;transcriptomics;Untranslated RNA;white matter

PROJECT_TITLE: Elucidating Regulatory Mechanisms of Lamin B1 Expression in Autosomal Dominant Leukodystrophy

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Clinical Research;Lymphatic Research;Lymphedema;Women's Health Research

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

ORG_STATE: NY

PHR: PROJECT NARRATIVE/RELEVANCE Secondary lymphedema is a common and morbid complication of surgical cancer treatment. Understanding the pathophysiology of the disease is a necessary step for developing novel and effective treatments. This study will analyze the role of epidermal cells in coordinating inflammatory responses in lymphedema, an innovative ap- proach that will help uncover how chronic inflammatory reactions in lymphedema are initiated and maintained.

PI_NAMEs: MEHRARA, BABAK J (contact)

PROGRAM_OFFICER_NAME: UNDALE, ANITA H

PROJECT_TERMS: Acidity;Alkalinization;American;Animal Model;Antibiotics;Atopic Dermatitis;Biopsy;breast surgery;cancer complication;cancer therapy;CD4 Positive T Lymphocytes;Cells;Chronic;chronic inflammatory skin;Clinical;cytokine;Deformity;Deposition;Dermis;Developed Countries;Development;Disease;Disease Progression;effective therapy;Epidermis;Functional disorder;Functional impairment;Goals;Gynecologic;High Prevalence;Histologic;Hospitalization;iatrogenic injury;Immune response;Impairment;improved;Infectious Skin Diseases;Infiltration;Inflammation;Inflammatory;Inflammatory Response;inhibiting antibody;Injury;innovation;Intravenous;keratinocyte;Kininogenase;Knowledge;laboratory experience;loss of function;Lymphatic;lymphatic pump;lymphatic vessel;Lymphedema;Malignant Breast Neoplasm;Mediating;Mediator;Melanoma;Methods;mouse model;Mus;novel;Outcome;Pain;palliative;Palliative Care;PAR-2 Receptor;Pathologic;Pathology;Pathway interactions;Patients;Peptide Hydrolases;Pharmaceutical Preparations;Phase I Clinical Trials;Physical therapy;Play;Positioning Attribute;Pre-Clinical Model;prevent;Prevention;Proteins;Quality of life;Reaction;Recurrence;recurrent infection;reduce symptoms;response;Risk;Role;Sarcoma;secondary lymphedema;Serine Protease;Serine Proteinase Inhibitors;Severity of illness;Signal Pathway;Skin;Skin Abnormalities;skin barrier;skin disorder;Skin Manifestations;Solid Neoplasm;Stains;Stratum corneum;Surgical complication;Swelling;symptom treatment;T-Lymphocyte;Testing;Tissues;TSLP gene;tumor;Upper Extremity;urologic;Urologic Cancer

PROJECT_TITLE: Role of epidermis in regulating inflammatory skin manifestations of post-surgical lymphedema


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Congenital Heart Disease;Congenital Structural Anomalies;Heart Disease;Infant Mortality;Lung;Orphan Drug;Patient Safety;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Rare Diseases

ORG_CITY: Aurora

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF COLORADO DENVER

PHR: Project Narrative  Children who are born with a single pumping chamber in their heart instead of the usual two are particularly dependent on the health of their lung vessels to ensure blood flows freely through their lungs. Despite the importance of the lung blood vessels to SVHD patients, options to diagnose and treat inadequate lung vessel growth are limited; we are interested in testing if endothelin-1 (ET1, a small molecule that causes lung blood vessel walls to thicken) or two amino acid pathways (arginine and tryptophan, amino acids whose family of molecules can cause the pulmonary artery vessel walls to constrict) are present in abnormal concentrations in SVHD patients over time. This study will help us determine if the arginine and tryptophan pathways and ET1 are important in SVHD patients and will accelerate the identification of new drug targets to improve blood flow to the lungs.

PI_NAMEs: FRANK, BENJAMIN S (contact)

PROGRAM_OFFICER_NAME: NEILSON, KAREN MARY

PROJECT_TERMS: 4D MRI;Acceleration;Affect;Amino Acids;antagonist;Arginine;Biological Markers;Blood flow;Blood Vessels;Bronchitis;cardiac magnetic resonance imaging;career development;Cell Proliferation;Cessation of life;Child;Childhood;Chronic;Cirrhosis;Clinical;clinical diagnostics;Clinical Sciences;Clinical Trials;Clinical Trials Design;Common Ventricle;congenital heart abnormality;constriction;Cross-Sectional Studies;Data;Data Analyses;design;Development;Diagnosis;diagnostic biomarker;Diagnostic tests;Disease;Disease Marker;Drainage procedure;Endothelin A Receptor;Endothelin-1;Ensure;Evaluation;experience;Failure;Family;Fontan Procedure;Funding;Future;Glutamates;Glutamine;Goals;Growth;Health;Heart;Hypoxemia;Impairment;improved;indexing;innovation;interest;Intervention;Length of Stay;Link;Liquid substance;Longitudinal Studies;Lung;Magnetic Resonance Imaging;Maps;Master of Science;Measures;Metabolic;Metabolic Pathway;metabolomics;Methods;Monitor;Morbidity - disease rate;new therapeutic target;Nitric Oxide;novel;novel marker;operation;Operative Surgical Procedures;Outcome;Oxygen;palliation;Pathologic;Pathway interactions;Patients;Perioperative;Phenotype;Pleural;Pleural effusion disorder;Population;Positioning Attribute;Postoperative Complications;Postoperative Period;Prospective, cohort study;protein biomarkers;Protein-Losing Enteropathies;Publications;Pulmonary artery structure;Pulmonary Valve Insufficiency;pulmonary vascular disorder;Pulmonary Vascular Resistance;Pump;Readiness;Research;Research Design;Risk;Serology;Serum;Severities;Single ventricle congenital heart disease;skills;small molecule;Smooth Muscle Myocytes;Testing;therapeutic target;Time;timeline;Tryptophan;Tryptophan Metabolism Pathway;Vasoconstrictor Agents;Vasodilator Agents

PROJECT_TITLE: Pulmonary Vascular Development in Single Ventricle Heart Disease: A Longitudinal Biomarker Approach

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(OA)]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: Springfield

ORG_NAME: OREGON RESEARCH INSTITUTE

ORG_STATE: OR

PHR: PROJECT NARRATIVE The COVID-19 pandemic has had a detrimental effect on mental health, especially for emerging adults. Utilizing the longitudinal Early Steps Multisite prevention trial of diverse, low-income families (N=731) from three geographic areas across the United States, we plan to take advantage of an 18-year-long prospective dataset in conjunction with new mental health assessments to examine risk and resilience factors for at-risk emerging adults, transitioning from adolescence to adulthood in the context of a pandemic. With genotyping on an extensive contemporary array, prospective data on experiences of discrimination, and neighborhood and community risk/resilience factors, we plan to examine direct, interactive, and cascading effects on mental health outcomes, and the long-term preventive effects of the Family Check-Up, in the context of growing up in poverty, and, more recently, the pandemic.

PI_NAMEs: BROWN-IANNUZZI, JAZMIN ;LEMERY-CHALFANT, KATHRYN ;SHAW, DANIEL S;WESTLING, ERIKA  (contact)

PROGRAM_OFFICER_NAME: ROONEY, MARY

PROJECT_TERMS: 2019-nCoV;Adolescence;Adult;Age;age group;American;Anxiety;Attention;Behavioral;biological sex;Buffers;caucasian American;Characteristics;checkup examination;Child;clinical diagnostics;Communities;coping;Coronavirus;COVID-19;COVID-19 pandemic;Data;Data Set;design;Deterioration;Development;dietary supplements;Disease;early childhood;Early Intervention;Ecology;Economics;emerging adult;emerging adulthood;Emotional;Environmental Risk Factor;ethnic disparity;ethnic diversity;ethnic identity;ethnic minority;Ethnic Origin;Ethnic Population;experience;Exposure to;Family;Future;Gender Identity;Genetic;Genetic Predisposition to Disease;Genetic Risk;genetic testing;Genotype;Geographic Locations;Geography;Glean;health assessment;health inequalities;High Prevalence;higher education;Home;Individual;Inequality;Infant;Informal Social Control;Institutional Racism;Intervention;intervention effect;Interview;Link;Long-Term Effects;Longitudinal Studies;lower income families;Mediating;Mental Depression;Mental Health;Minority Groups;Neighborhoods;Outcome;pandemic disease;pandemic potential;pandemic stress;Parents;Participant;perceived discrimination;physical conditioning;polygenic risk score;Poverty;pre-pandemic;Predictive Factor;prevent;Prevention;Prevention trial;Preventive;Problem behavior;prospective;protective effect;protective factors;Psychoses;Public Health;Race;racial discrimination;racial disparity;racial diversity;racial minority;racial population;racism;Randomized;recruit;Reporting;Research;resilience;resilience factor;Risk;Risk Factors;risk mitigation;Rural;Sampling;Shock;Site;social culture;social determinants;social factors;Social Identification;Social isolation;Socialization;Societies;sociocultural determinant;sociodemographics;socioeconomics;stressor;suburb;suicidal;Suicide;Support System;Surveys;Symptoms;Testing;Time;transition to adulthood;United States;Vocation;Woman;young adult

PROJECT_TITLE: Preventing Adult Mental Health Problems from Early Childhood in the Contexts of Genetic Susceptibility, Poverty, Racism, and the COVID-19 Pandemic

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: Narrative A subset of T cells, regulatory T cells (Tregs) and plasma High Density Lipoproteins (HDL) both control immune responses, and curb inflammation. We found that HDL can directly promote Tregs survival, revealing possible cooperation between these two separate processes. By exploring how this works, we will have sustained impact on both the fields of lipoprotein biology and immunology and our work will open new avenues for potential therapeutic interventions in a host of auto- immune and chronic metabolic diseases.

PI_NAMEs: CHOUGNET, CLAIRE A. (contact);DAVIDSON, W SEAN

PROJECT_TERMS: adaptive immune response;Adolescent;Agreement;AKT Signaling Pathway;Animal Model;Anti-Inflammatory Agents;Apolipoprotein E;Apolipoproteins;Apoptosis;Attention;Autoimmune;Autoimmune Diseases;bariatric surgery;Binding;Biochemistry;Biological Markers;Biology;Body Weight decreased;Cardiovascular Diseases;cardiovascular disorder risk;Caspase;CD4 Positive T Lymphocytes;Cell Communication;Cell Count;Cell Physiology;Cell Survival;Characteristics;Chemicals;Childhood diabetes;Cholera Toxin Protomer B;Chronic;cohort;Complex Mixtures;Data;experimental study;Family;Fatty Acids;Future;Heparan Sulfate Proteoglycan;High Density Lipoprotein Cholesterol;High Density Lipoproteins;Homeostasis;Human;Immune response;Immunity;Immunology;improved;in vivo;Inflammation;Inflammatory;inflammatory milieu;Innate Immune Response;insight;Intraperitoneal Injections;knock-down;Lipids;Lipoprotein Binding;Lipoproteins;longitudinal analysis;Mediating;Membrane Microdomains;Memory;Metabolic Diseases;Minor;Mitochondria;Morbid Obesity;Mus;novel;obese person;Obesity associated disease;obesity in children;Operative Surgical Procedures;Oxidative Stress;particle;Pathology;Pathway interactions;Plasma;Play;pleiotropism;Process;Proteins;Proto-Oncogene Proteins c-akt;Publishing;receptor;Recombinants;reconstitution;Regulatory T-Lymphocyte;Role;Scaffolding Protein;scavenger receptor;Signal Pathway;Site-Directed Mutagenesis;Small Interfering RNA;syndecan;synthetic peptide;System;T memory cell;T-Lymphocyte Subsets;Techniques;Teenagers;Testing;Therapeutic;Therapeutic Intervention;Vesicle;Weight;Work

PROJECT_TITLE: Role of apoE in HDL-mediated enhanced survival of human regulatory T-cells

STUDY_SECTION: AVI

STUDY_SECTION_NAME: Atherosclerosis and Vascular Inflammation Study Section[AVI]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Clinical Research;Networking and Information Technology R&D (NITRD);Pain Research

ORG_CITY: BROOKLYN

ORG_NAME: KILLER SNAILS LLC

PHR: There is an urgent need for learning initiatives that make science both approachable and relevant to American middle school students. This SBIR FastTrack award will enable Killer Snails, LLC to develop and commercialize VenomSquad, an immersive learning experience that leverages mobile augmented reality to put students in the role of scientists collaborating to solve a real-world problem: finding new, non-addictive pain therapies based on the venom of extreme creatures like scorpions, snakes, and cone snails. VenomSquad engages students with authentic health and medicine content while offering educators assessment tools to enhance students’ use of science and engineering practices, STEM identity, and interest in future careers in science and medicine, and a roadmap of best practices for applying emerging technologies in science learning for educators.

PI_NAMEs: HENDRIX, JESSICA OCHOA (contact)

PROGRAM_OFFICER_NAME: FAUPEL-BADGER, JESSICA

PROJECT_TERMS: Address;Affect;American;Animals;Assessment tool;Augmented Reality;Award;Behavior;Black, Indigenous, People of Color;career;Cellular Phone;Collaborations;commercial application;commercialization;Communication;Cone;Country;dashboard;Data;design;Development;digital;digital media;digital models;Disabled Persons;Education;Educational Curriculum;Educational Technology;efficacy evaluation;eighth grade;Emerging Technologies;Engineering;Ensure;Evaluation;experience;Feedback;formative assessment;Fostering;Future;Goals;handheld mobile device;Health;Individual;informal learning;innovation;Instruction;interactive tool;interest;Journals;junior high school;Knowledge;Knowledge acquisition;Learning;Legal patent;Life;Maps;Marketing;materials science;Medicine;Middle School Faculty;Middle School Student;Monitor;Multimedia;multimodal learning;Mus;Museums;Nervous System;Next Generation Science Standards;Online Systems;Outcome;Pain;Pain management;Peptides;Pharmaceutical Preparations;Phase;physical science;Play;Polishes;Problem Solving;Process;prototype;Research Personnel;Resource Sharing;Role;Sales;scaffold;Schools;Science;Scientist;Scorpions;simulation;Site;skills;Small Business Innovation Research Grant;Snails;Snake Venoms;Snakes;Spottings;STEM career;STEM field;STEM student;student participation;Students;Technology;Testing;Therapeutic;Time;Underrepresented Populations;usability;Venoms;web site;Woman;Work

PROJECT_TITLE: VenomSquad: Building skills and interest in STEM with collaborative augmented reality


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Hearing Loss;Rehabilitation;Rural Health;Social Determinants of Health

ORG_CITY: TUSCALOOSA

ORG_NAME: UNIVERSITY OF ALABAMA IN TUSCALOOSA

PHR: Project Narrative The proposed research is relevant to public health because it will address quality of care issues associated with hearing loss in adults who have mild-to-moderate hearing loss and who have no access to hearing healthcare. This project will identify the needs of adults living in rural communities and will use this information to develop effective intervention strategies to mitigate the negative effects of hearing loss. This information is important to NIH’s mission because it will lead to options that will increase access and affordability of hearing healthcare for adults with mild-to-moderate hearing loss, a specific goal of NIDCD.

PI_NAMEs: HAY-MCCUTCHEON, MARCIA JEAN (contact)

PROGRAM_OFFICER_NAME: KING, KELLY ANNE

PROJECT_TERMS: Address;Adopted;Adult;Affect;Alabama;Area;Arizona;Audiology;aural rehabilitation;Baltimore;Certification;Clinic;Clinical Trials;Collaborations;Communication;Communities;community based participatory research;Community Health;community intervention;cost;Country;design;effective intervention;Effectiveness;Family;Family member;Financial Support;Focus Groups;Fostering;Goals;Health Services Accessibility;Healthcare;Hearing;Hearing Aids;hearing impairment;Impaired cognition;implementation intervention;Improve Access;improved;Income;Individual;Infrastructure;Intervention;Licensing;Mental Depression;Misinformation;Mission;Modeling;National Institute on Deafness and Other Communication Disorders;Needs Assessment;Participant;Phase;Pilot Projects;Play;poor communities;Poverty Areas;Program Development;programs;Psychologist;Public Health;Quality of Care;Quality of life;Randomized;rehabilitation service;Rehabilitation therapy;Research;Research Personnel;Resources;Role;rural area;Rural Community;Service delivery model;Social isolation;sound;Speech;Speech Perception;Stress;success;Supervision;Technology;Testing;Training Programs;Travel;treatment group;underserved area;underserved community;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Improving Access and Affordability of Adult Hearing Healthcare: Effectiveness of Community-based Interventions in West Central and South Alabama


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;Clinical Research;HIV/AIDS;Immunization;Immunotherapy;Infectious Diseases;Prevention;Vaccine Related

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE HIV infection remains a chronic disease requiring life-long therapy and creating a substantial burden for both patients and the healthcare system, therefore, efforts to eradicate HIV infection, or at least induce a state of viral control and drug-free remission are needed. This proposal examines the potential of a novel vaccine strategy to enhance the body's immune response to better control the virus and destroy HIV infected cells. The insights generated in this proposal will help maximize efficacy of current and future therapeutic vaccine strategies.

PI_NAMEs: JUELG, BORIS DOMINIK (contact)

PROGRAM_OFFICER_NAME: ZHOU, YAN

PROJECT_TERMS: Adenoviruses;AIDS prevention;Antigens;antiretroviral therapy;Bioinformatics;booster vaccine;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Count;cell growth;Cells;Characteristics;Chronic;Chronic Disease;Chronic Phase;cohort;cross reactivity;Cytotoxic T-Lymphocytes;Data;Disease remission;env Gene Products;Epitopes;experience;Future;Generations;Genome;Goals;Healthcare Systems;HIV;HIV Infections;HIV vaccine;HIV-1;Immune;Immune response;immunogenic;Immunosuppression;improved;Individual;Infection;insight;Interruption;latent HIV reservoir;Leukapheresis;Macaca mulatta;Maps;Mediating;Memory;Modeling;Modernization;Modification;Modified Vaccinia Virus Ankara;mosaic;Mutation;Nature;nonhuman primate;novel;novel vaccines;Patients;Pharmaceutical Preparations;phase 1 study;Phase I Clinical Trials;Phenotype;Plasma;Population;pre-clinical;Predisposition;pressure;Prevention strategy;Procedures;rational design;Regimen;response;side effect;SIV;success;T cell response;T-Cell Receptor;T-cell receptor repertoire;T-Lymphocyte;Technology;Testing;Thailand;Therapeutic;therapeutic vaccine;Vaccination;vaccination outcome;vaccine candidate;vaccine strategy;Vaccine Therapy;vaccine trial;vaccine-induced immunity;Vaccinee;Vaccines;Variant;vector;vector-based vaccine;Viral;Viral Load result;viral rebound;Viral reservoir;Virus;Virus Integration;Virus Replication

PROJECT_TITLE: Optimizing HIV-specific T-cell responses by therapeutic vaccination

STUDY_SECTION: VACC

STUDY_SECTION_NAME: HIV/AIDS Vaccines Study Section[VACC]


NIH_SPENDING_CATS: Behavioral and Social Science;Child Abuse and Neglect Research;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Mental Health;Pediatric;Physical Injury - Accidents and Adverse Effects;Prevention;Social Determinants of Health;Violence Research

ORG_CITY: MINNEAPOLIS

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative This application proposes a feasibility study designed to inform the development of a multinational study of the effectiveness of a tertiary prevention program for child sexual abuse. This study targets adult men who have engaged in child sexual abuse, and will be implemented within the Minnesota Department of Corrections. Data will include measures of the implementation process, short-terms changes in criminogenic factors, and staff and participant factors that could influence outcomes.

PI_NAMEs: MINER, MICHAEL H (contact)

PROGRAM_OFFICER_NAME: GILBERT, LEAH KAYE

PROJECT_TERMS: 14 year old;Address;Adult;Aftercare;Age;aged;Attitude;Behavioral;Belief;boys;California;Canada;Characteristics;Child Development;Child Health;Child Sexual Abuse;Clinical Trials;Collaborations;Consensus;Data;design;Development;Effectiveness;Effectiveness of Interventions;effectiveness study;efficacy testing;Empirical Research;experience;Experimental Designs;Feasibility Studies;feasibility testing;Funding;Generations;girls;Goals;Grant;Humanities;implementation fidelity;implementation intervention;implementation measures;Imprisonment;improved;Incidence;Individual;innovation;instrument;International;Intervention;intervention delivery;Knowledge;Longitudinal Studies;male;Measurement;Measures;men;Mental Health;Meta-Analysis;Methods;Minnesota;Modeling;Modification;Motivation;National Institute of Child Health and Human Development;offender;Outcome;Outcome Study;Participant;Patient Self-Report;Pattern;perpetrators;Personality Disorders;Pilot Projects;pilot test;prevent;Prevention approach;Prevention program;Procedures;Process;Process Measure;Program Effectiveness;programs;Psychometrics;Public Health;public health priorities;Publishing;Random Allocation;Randomized;recruit;Regulation;relapse prevention;Reporting;Research;Research Design;response;Risk;Sample Size;Sampling;Sexual abuse;sexual violence;social;Social Sciences;Statistical Data Interpretation;symposium;tertiary prevention;Testing;Therapeutic;therapy design;treatment as usual;Treatment outcome;treatment program;Uncertainty

PROJECT_TITLE: Mobilizing evidence into tertiary prevention of child sexual abuse: A pilot study


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Lung;Orphan Drug;Rare Diseases;Tuberculosis

ORG_CITY: PORTLAND

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

PHR: Project Narrative The L,D-transpeptidases (LDTs) are an alternative, high-priority target of β-lactam antibiotics. We propose a discovery-driven project, wherein a set of molecular probes will be used to detect and identify β-lactam drug targets in dormant and actively-replicating pathogens, including Mycobacterium tuberculosis. This project fits the goal of NIAID to use research and technology to better understand and treat infectious diseases.

PI_NAMEs: BEATTY, KIMBERLY ELIZABETH (contact)

PROGRAM_OFFICER_NAME: BOYCE, JIM P

PROJECT_TERMS: Amoxicillin;Anabolism;Antibiotics;beta-Lactams;Biochemical;Biology;Cell Wall;Cells;Chemicals;Clavulanate;Clinical;clinically relevant;Combined Modality Therapy;Communicable Diseases;cost;Critical Illness;crosslink;Disease;drug development;Drug resistance;Drug resistance in tuberculosis;Drug Targeting;effective therapy;Enzyme Inhibition;Enzymes;esterase;Exposure to;Gel;Genus Mycobacterium;Goals;Human;Infection;inhibitor;insight;L Forms;Lung;Lung Diseases;Meropenem;Microscopy;Molecular;molecular imaging;Molecular Probes;Monitor;mycobacterial;Mycobacterium abscessus;Mycobacterium Infections;Mycobacterium tuberculosis;National Institute of Allergy and Infectious Disease;non-tuberculosis mycobacteria;novel therapeutic intervention;novel therapeutics;pathogen;Pathogenesis;Patients;Penicillin-Binding Proteins;Peptidoglycan;Peptidyltransferase;Persons;Pharmaceutical Preparations;Predisposition;preference;Process;programs;Proteins;Regulation;Reporting;Research;resistant strain;Role;small molecule;spatiotemporal;Speed;Structure;success;Sulfatases;Technology;Therapeutic;tool;Treatment Protocols;treatment strategy;Tuberculosis;tuberculosis treatment;United States;Work

PROJECT_TITLE: Evaluating the Role of L,D-Transpeptidases in Mycobacterial Pathogenesis

STUDY_SECTION: SBCA

STUDY_SECTION_NAME: Synthetic and Biological Chemistry A Study Section[SBCA]


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Cancer;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Colorectal Cancer;Digestive Diseases;Neurodegenerative;Neurosciences;Pain Research;Patient Safety;Peripheral Neuropathy;Prevention

ORG_CITY: BIRMINGHAM

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

PHR: About 70% of patients with colorectal cancer who receive oxaliplatin will develop oxaliplatin-induced peripheral neuropathy (OIPN): numbness, tingling, and pain in the toes/feet and fingers/hands that can last for years. OIPN poses a serious health risk because it causes disability, falls, depression, impaired sleep, poor quality of life, and the need to reduce or stop oxaliplatin treatment. This randomized controlled trial will test a well- tolerated, widely available, non-opioid, preventive treatment for a debilitating chemotherapy side effect (OIPN) experienced by millions of cancer survivors, for which there is no good treatment.

PI_NAMEs: SMITH, ELLEN MARY LAVOIE (contact)

PROGRAM_OFFICER_NAME: STRECK, BRENNAN PARMELEE

PROJECT_TERMS: Academy;Address;Adverse event;Affect;Aftercare;arm;Brief Pain Inventory;Cancer Survivor;chemotherapy;Chemotherapy-induced peripheral neuropathy;chronic neuropathic pain;chronic pain management;Clinical;Clinical Trials;Colorectal Cancer;Common Terminology Criteria for Adverse Events;Community Clinical Oncology Program;Data;design;Diagnosis;disability;Disease;Distress;dosage;Dose;Double-Blind Method;duloxetine;experience;falls;Fingers;foot;Functional impairment;Goals;Hand;Health;Impairment;Institute of Medicine (U.S.);Knowledge;Lead;Lower Extremity;Malignant Neoplasms;Measures;Medicine;Mental Depression;Multicenter Studies;National Cancer Institute;non-opioid analgesic;Numbness;oxaliplatin;Pain;pain relief;pain score;patient population;Patients;Pattern;Peripheral Nervous System Diseases;Persons;Phase;phase 2 study;phase 3 study;phase III trial;Placebo Control;Placebos;pre-clinical;prevent;Prevention;Prevention trial;preventive intervention;Preventive treatment;programs;Quality of life;Questionnaires;Randomized;Randomized, Controlled Trials;Rattus;Recommendation;Reporting;Research;Research Design;Resources;response;Risk;Safety;Severities;side effect;Site;Sleep disturbances;Symptoms;Testing;Toes;Toxic effect;Treatment-Related Cancer;United States;Upper Extremity

PROJECT_TITLE: Duloxetine to Prevent Oxaliplatin-Induced Chemotherapy-Induced Peripheral Neuropathy: A Randomized, Double-Blind, Placebo-Controlled Phase II to Phase III Study

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IFCN-N(80)]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Immunotherapy;Infectious Diseases;Influenza;Pneumonia and Influenza

ORG_CITY: PHILADELPHIA

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

PHR: PROJECT NARRATIVE Post-influenza secondary bacterial infection (super-infection) can cause a cytokine storm, an overexuberant immune response, which leads to irreparable damage to the infected lungs. Eicosanoids are lipid mediators that play critical roles in the induction and resolution of inflammation during microbial infections. Deciphering the mechanism by which lipid mediators escalate a harmful inflammatory response will provide insights for developing novel therapeutic strategies for severe viral infections and their potentiated clinical complications.

PI_NAMEs: TAM, VINCENT  (contact)

PROGRAM_OFFICER_NAME: LEITNER, WOLFGANG W

PROJECT_TERMS: Affect;Alveolar Macrophages;Animals;Anti-Bacterial Agents;Anti-Inflammatory Agents;Bacterial Infections;Cell Physiology;Cell Survival;Cells;Cellularity;Cessation of life;Chemicals;Clinical;clinically relevant;Complication;cytokine release syndrome;Disease;Disease Outcome;eicosanoid metabolism;Eicosanoids;Electrospray Ionization;Failure;fatty acid metabolism;Fatty Acids;Gene Expression Profiling;Genetic;Genetic Models;Genetic Transcription;Goals;Homeostasis;Human;human disease;Immune;Immune response;Immune signaling;Immune system;Immunologics;immunoregulation;Immunotherapeutic agent;improved;In Vitro;Infection;Inflammation;Inflammatory;Inflammatory Response;Influenza;influenza infection;inhibitor;insight;Investigation;Knockout Mice;lipid mediator;lipid metabolism;lipidomics;Lipids;Lung;Macrophage;mass spectrometric imaging;Mass Spectrum Analysis;Mediating;Metabolic Pathway;Metabolism;microbial;Modeling;Molecular;mouse model;Mus;nano-string;new therapeutic target;novel therapeutic intervention;Nuclear Receptors;pathogen;pathogenic bacteria;Patients;Peroxisome Proliferator-Activated Receptors;Phase;Physiological;Play;Pneumonia;PPAR alpha;PPAR gamma;Process;Production;recruit;Research;Resolution;response;Role;Sampling;SARS-CoV-2 infection;secondary infection;Serum;severe COVID-19;Signal Transduction;Signaling Molecule;Spatial Distribution;Staphylococcus aureus;Staphylococcus aureus infection;superinfection;System;Systems Biology;Time;Tissues;transcription factor;Viral Load result;Virus Diseases;Work

PROJECT_TITLE: The Role of Eicosanoid-PPAR axis in Exacerbating Post-Influenza Staphylococcus aureus Super-infection

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


NIH_SPENDING_CATS: Cancer;Cervical Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;HPV and/or Cervical Cancer Vaccines;Health Services;Immunization;Infectious Diseases;Pediatric;Prevention;Primary Health Care;Sexually Transmitted Infections;Social Determinants of Health;Vaccine Related;Women's Health Research

PHR: PROJECT NARRATIVE Poor quality primary care providers' vaccine recommendations lead to low adolescent human papillomavirus vaccination rates and hundreds of thousands of adolescents unnecessarily at risk for HPV-associated cancers and diseases. Though our provider communication intervention, called PCOM, was found to be effective for increasing adolescent HPV vaccination in primary care, its dissemination is limited by the need for significant research team involvement to teach providers how to use the intervention's components. To address this, we propose to develop and test a virtual version of PCOM, use mixed methods to assess contextual factors affecting its use compared to the original PCOM intervention, and develop an optimized version of PCOM for broad dissemination to increase adolescent HPV vaccination nationally.

PI_NAMEs: O'LEARY, SEAN T (contact)

PROGRAM_OFFICER_NAME: CHOLLETTE, VERONICA

PROJECT_TERMS: 12 year old;Address;Adolescent;Affect;Age;Anogenital cancer;Anogenital venereal warts;Cervical;Characteristics;Clinical;Cluster randomized trial;Communication;comparative effectiveness trial;comparative efficacy;contextual factors;Cost Analysis;Data;Disease;Dissemination and Implementation;E-learning;Educational process of instructing;Ensure;Failure;Fostering;Geography;Goals;HPV vaccine acceptance;HPV vaccine hesitancy;Human papilloma virus infection;Human Papilloma Virus Vaccination;Human Papilloma Virus Vaccine;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;implementation intervention;implementation science;improved;Infection prevention;Intervention;Kansas;Lead;Libraries;Link;Locales;Malignant neoplasm of cervix uteri;malignant oropharynx neoplasm;Manuals;Methods;motivational enhancement therapy;Pap smear;Parents;patient population;Patients;penis;Physicians;Population;Practical Robust Implementation and Sustainability Model;premalignant;prevent;Primary Care;primary care practice;primary care provider;Process;prototype;Provider;provider communication;Public Health;Randomized;randomized, clinical trials;Recommendation;recruit;Reporting;Research;Risk;Rural;Series;Services;Sexually Transmitted Diseases;Techniques;Testing;Trainers Training;Training;Translating;Treatment Efficacy;Vaccinated;Vaccination;vaccine acceptance;vaccine hesitancy;Vaccines;Vagina;verbal;virtual;virtual intervention;Virus;Work

PROJECT_TITLE: PCOM2 - The Physician Communication Intervention, Version 2.0

STUDY_SECTION: SIHH

STUDY_SECTION_NAME: Science of Implementation in Health and Healthcare Study Section[SIHH]


NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Neurosciences;Nutrition

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Insects transmit a wide variety of diseases to hundreds of millions of people each year, and the geographic ranges of some of these diseases have been increasing. Many of these insects rely on their chemosensory systems to identify their human hosts, their food, and their mates. This project is designed to elucidate how these systems operate and could lead to new means of manipulating them so as to control these insect vectors of disease.

PI_NAMEs: CARLSON, JOHN R (contact)

PROGRAM_OFFICER_NAME: SULLIVAN, SUSAN L

PROJECT_TERMS: Animals;Attention;base;Biological Models;Cells;Code;Collection;design;Disease;Drosophila genus;Electrophysiology (science);Equilibrium;experimental study;Family;fly;Food;Freedom;Frequencies;gain of function;Genes;genetic analysis;Geography;Goals;Human;human disease;Immune Response Genes;Individual;Ingestion;innovation;Insect Control;insect disease vector;Insect Vectors;Insecta;insight;loss of function;Maps;Measurement;Measures;Molecular;Molecular Genetics;mutant;Neurons;Olfactory Pathways;Organism;Partner in relationship;Persons;Physiological;postsynaptic;Prevalence;receptor;Receptor Gene;response;Role;sensory system;Source;Stimulus;sugar;System;Taste Buds;Taste Perception;taste stimuli;taste system;Testing;Time;Toxin;transmission process;virtual

PROJECT_TITLE: Analysis of a Large Family of Candidate Taste Receptors

STUDY_SECTION: NIC

STUDY_SECTION_NAME: Neuroscience of Interoception and Chemosensation Study Section[NIC]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Frontotemporal Dementia (FTD);Neurodegenerative;Neurosciences

ORG_CITY: JACKSONVILLE

ORG_NAME: MAYO CLINIC  JACKSONVILLE

ORG_STATE: FL

PHR: Frontotemporal lobar degeneration (FTLD) is a progressive neurodegenerative disease negatively affecting the personality, behavior and language of patients, for which there is no cure. Our goals are to define the abnormal processes that contribute to the development of FTLD, as well as devise strategies to monitor and prevent disease progression. The novel insight and translational nature of our findings are expected to transform the field and improve the prognosis for patients with FTLD.

PI_NAMEs: PETRUCELLI, LEONARD  (contact)

PROGRAM_OFFICER_NAME: SHEWMAKER, FRANK PAUL

PROJECT_TITLE: Expanding insights into FTD disease mechanisms