ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Eye Disease and Disorders of Vision;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_NAME: NATIONAL EYE INSTITUTE

PI_NAMEs: MAMINISHKIS, ARVYDAS  (contact)

PROJECT_TERMS: Adverse event;Animal Model;Basic Science;Clinic;Clinical;Clinical Trials;Collaborations;combat;Data;Elements;Environment;Eye;Eye Injuries;Human;Immunologics;Implant;induced pluripotent stem cell;instrumentation;Methodology;Modeling;Operative Surgical Procedures;Positioning Attribute;pre-clinical;Preparation;Process;Rattus;reconstruction;replacement tissue;Research;Research Personnel;Retina;sight restoration;Soldier;Specialist;success;Surgeon;Techniques;Therapeutic Intervention;tool;Training;Translating;translational goal;Translational Research;United States National Institutes of Health;Validation;Veterinarians

PROJECT_TITLE: Translational Research Core


ADMINISTERING_IC: HL

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: WORCESTER

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

ORG_STATE: MA

PHR: Project Narrative We will perform a genotype driven trial assessing the efficacy of NAC in patients with TOLLIP rs3750920 T/T genotype. We will also molecularly endophenotype all patients with IPF and ILD in the PFF biospecimen repository using whole genome sequencing, RNA sequencing and proteomics.

PI_NAMEs: MARTINEZ, FERNANDO J (contact);NOTH, IMRE

PROGRAM_OFFICER_NAME: GOMEZ, CHRISTIAN RENE

PROJECT_TITLE: 1/2 Prospective tReatment EffiCacy in IPF uSlng genOtype for Nac Selection (PRECISIONS) trial and Molecular Endophenotyping in Idiopathic Pulmonary Fibrosis and Interstitial Lung Diseases study

STUDY_SECTION: CLTR

STUDY_SECTION_NAME: Clinical Trials Review Study Section[CLTR(MA)]


PHR: PROJECT NARRATIVE More effective treatments for idiopathic pulmonary fibrosis are urgently needed. In this phase I study, we will assess the safety of a green tea extract, epigallocatechin-3-gallate (EGCG) in combination with nintedanib or pirfenidone, as a novel antifibrotic agent in patients with idiopathic pulmonary fibrosis.

PI_NAMEs: CHAPMAN, HAROLD A;MARTINEZ, FERNANDO J (contact);SPINO, CATHERINE A

PROJECT_TITLE: Phase 1 study of oral epigallocatechin-3-gallate (EGCG) in IPF patients


ADMINISTERING_IC: AI

FUNDING_MECHANISM: NON SBIR/STTR CONTRACTS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: HIV/AIDS;Infectious Diseases;Microbiome;Prevention;Sexually Transmitted Infections;Topical Microbicides;Women's Health Research

ORG_CITY: KENSINGTON

ORG_NAME: ADVANCED BIOSCIENCE LABORATORIES, INC.

ORG_STATE: MD

PI_NAMEs: SWARTZ, GLENN  (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;AIDS prevention;anti-HIV microbicide;Clinical Trials;Development;Devices;Drug Kinetics;Evaluation;HIV;HIV Infections;Investigational Drugs;Licensure;microbicide;Modeling;National Institute of Allergy and Infectious Disease;novel therapeutics;Pathway interactions;Persons;Play;pre-clinical;pre-exposure prophylaxis;prevent;Prevention;Prevention strategy;Preventive vaccine;product development;research clinical testing;Resources;Role;Safety;Services;sexual HIV transmission;Sheep;sheep model;Technology;United States Food and Drug Administration;United States National Institutes of Health;vaginal microbiome;Work

PROJECT_TITLE: Ovine Model and Vaginal Microbiome Support for HIV Non-vaccine Biomedical Prevention Product Development


NIH_SPENDING_CATS: HIV/AIDS;Infectious Diseases;Prevention;Sexually Transmitted Infections;Topical Microbicides

PI_NAMEs: SILVERA, PETER  (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;AIDS prevention;anti-HIV microbicide;Clinical Trials;Contracts;Development;HIV Infections;Licensure;microbicide;National Institute of Allergy and Infectious Disease;Persons;Play;pre-clinical;pre-exposure prophylaxis;prevent;Prevention;Prevention strategy;Preventive vaccine;quality assurance;Quality Control;Recurrence;research clinical testing;Resources;Role;sexual HIV transmission;Technology;United States National Institutes of Health;Work

PROJECT_TITLE: Comprehensive Resources for HIV Microbicides and Biomedical Prevention: Quality Assurance/ Quality Control (QA/QC)


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Mental Health;Neurodegenerative;Neurosciences

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: "This contract is for post-mortem human brain collection sites (i.e. the NIH Brain and Tissue Repositories [NBTR]) for the NIH NeuroBioBank. This contract is part of a strategy by the NIH to maximize availability of post-mortem human biospecimens to the research community while simultaneously achieving greater efficiency and better coordination of brain and tissue repository resources through a centralized approach to brain banking." Alzheimer's Disease

PI_NAMEs: LEWIS, DAVID  (contact)

PROJECT_TERMS: Advocacy;Alzheimer's Disease;Autopsy;Brain;brain control;brain tissue;Collection;Communities;Contracts;Disease;Goals;Human;human disease;Mental disorders;National Institute of Child Health and Human Development;National Institute of Drug Abuse;National Institute of Mental Health;National Institute of Neurological Disorders and Stroke;National Institute on Aging;Nervous System Disorder;Neurodevelopmental Disorder;Patients;Process;Research;Resources;Site;Tissue Banks;Tissues;United States National Institutes of Health

PROJECT_TITLE: NBB BRAIN BANK


NIH_SPENDING_CATS: Clinical Research

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PI_NAMEs: CAI, JIANWEN  (contact)

PROJECT_TERMS: Accounting;Algorithms;Categories;Cells;Complex;Data;design;Drops;follow-up;Hispanic Community Health Study/Study of Latinos;Longitudinal Studies;Longitudinal Surveys;Methods;Participant;Performance;Prospective, cohort study;Research Project Grants;Sampling;simulation;Surveys;Time;tool;Visit;waist circumference;Weight

PROJECT_TITLE: HISPANIC COMMUNITY HEALTH STUDY - STUDY OF LATINOS COORDINATING CENTER DIVERSITY SUPPLEMENT FOR JOSE LOPEZ


NIH_SPENDING_CATS: Brain Disorders;Human Fetal Tissue;Mental Health;Neurosciences

ORG_CITY: BALTIMORE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PI_NAMEs: BLANCHARD, THOMAS  (contact)

PROJECT_TERMS: Advocacy;Autopsy;Brain;brain control;brain tissue;Collection;Communities;Contracts;Disease;Goals;Human;human disease;Mental disorders;National Institute of Child Health and Human Development;National Institute of Drug Abuse;National Institute of Mental Health;National Institute of Neurological Disorders and Stroke;National Institute on Aging;Nervous System Disorder;Neurodevelopmental Disorder;Patients;Process;Research;Resources;Site;Tissue Banks;Tissues;United States National Institutes of Health

PROJECT_TITLE: THE NIH NEUROBIOBANK AND TISSUE REPOSITORY


PI_NAMEs: THOMAS, BLANCHARD  (contact)


ADMINISTERING_IC: HD

FUNDING_MECHANISM: INTERAGENCY AGREEMENTS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Bioengineering;Data Science;Networking and Information Technology R&D (NITRD);Pediatric

PROJECT_TERMS: Adolescent;Agreement;Air;Architecture;Big Data;biomedical informatics;Catalogs;Child;Communities;Consultations;Contracts;Data;Data Collection;data ecosystem;data integration;Data Science;Data Set;data sharing;Development;Ecosystem;Fees;Funding;Goals;Government;Human;human centered design;Human Development;improved;Industry;innovation;interoperability;Laboratories;Life Cycle Stages;Massachusetts;Measurable;Mission;National Institute of Child Health and Human Development;Performance;Recommendation;Reproductive Health;Research;research and development;Research Personnel;Resources;Rights;Scientific Advances and Accomplishments;Secure;software development;Specimen;Systems Analysis;Technology;Time;tool;United States National Institutes of Health;Work

PROJECT_TITLE: NICHD DATA ECOSYSTEM DEVELOPMENT ROADMAP - DASH


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Cardiovascular;Physical Injury - Accidents and Adverse Effects

PROJECT_TERMS: 3-Dimensional;Acute;Award;Biological Models;biological systems;Cardiovascular system;Chronic;Contracts;Exposure to;Federal Government;Heart;Human;Human Pathology;in vivo;Longevity;microphysiology system;National Institute of Allergy and Infectious Disease;Planet Earth;radiation effect;Radiation exposure;Radiation induced damage;response;stressor;Technology;Tissue Microarray;Tissues;United States National Aeronautics and Space Administration;Universities

PROJECT_TITLE: Extended Longevity of 3D Tissues and Microphysiological Systems for Modeling of Acute and Chronic Exposures to Stressors


ADMINISTERING_IC: CA

ED_INST_TYPE: PRIMATE CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: ATLANTA

ORG_DEPT: PATHOLOGY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: NARRATIVE Breast cancer is the leading cause of cancer among women, with breast conserving surgery (BCS) often recommended as a standard treatment. Residual tumor left after BCS is a persistent concern due to its association with cancer recurrence, need for additional surgery, potential to cause patient anxiety, and risk for poor cosmetic outcomes. Here, we offer a new imaging strategy that can provide real-time feedback to the surgical team during the operation, as opposed to after the surgery has ended, to better guide breast tumor removal to reduce the need for additional surgeries and improve patient outcomes.

PI_NAMEs: FEREIDOUNI, FARZAD  (contact)

PROGRAM_OFFICER_NAME: DARDZINSKI, BERNARD JOSEPH

PROJECT_TERMS: Adipose tissue;Anxiety;Appearance;Area;Attention;Breast;Breast Cancer Treatment;Breast Diseases;breast imaging;breast lumpectomy;breast surgery;Breast-Conserving Surgery;Cancer Etiology;cancer recurrence;Carcinoma;Carcinoma in Situ;Caring;Clinical;clinical practice;Consumption;contrast enhanced;Cosmetics;cost;cost effective;Coupled;Diagnosis;diagnosis standard;Diagnostic;diagnostic accuracy;Diagnostic Imaging;diagnostic value;digital imaging;Engineering;Evaluation;Excision;experience;feasibility testing;Feedback;Fellowship;Fluorescence;Fresh Tissue;Frozen Sections;Glass;Goals;Health Care Costs;Healthcare;Healthcare Systems;Histology;Histopathology;Image;Image Enhancement;Image-Guided Surgery;imaging approach;imaging system;Imaging technology;improved;In Situ;instrumentation;Left;Lighting;Magnetic Resonance Imaging;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Gland Parenchyma;Mammary Neoplasms;Mastectomy;Measures;Mechanics;Methodology;Methods;microscopic imaging;Microscopy;Molecular;Morbidity - disease rate;novel;operation;Operative Surgical Procedures;Optics;Outcome;Pathologist;Pathology;Patient-Focused Outcomes;Patients;Postoperative Period;preservation;Procedures;Process;psychosocial;Publishing;Qualifying;Radiation therapy;Reader;Recommendation;recruit;Recurrence;Recurrent tumor;Repeat Surgery;Reporting;Residual Neoplasm;Residual state;Resolution;Risk;safety and feasibility;Scanning;Sectioning technique;Sensitivity and Specificity;Series;Slide;Specificity;Specimen;Speed;Stains;standard care;standard of care;Surface;Surgeon;Surgical margins;System;Techniques;Technology;Testing;Thinness;Time;Tissue imaging;tissue processing;Tissues;tool;Training;tumor;United States;validation studies;Woman

PROJECT_TITLE: GigaFIBI; rapid, large-format histology-resolution imaging for Intraoperative assessment of breast lumpectomy margins

STUDY_SECTION: IGIS

STUDY_SECTION_NAME: Imaging Guided Interventions and Surgery Study Section[IGIS]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

ORG_CITY: FREDERICK

ORG_NAME: LEIDOS BIOMEDICAL RESEARCH, INC.

PI_NAMEs: FORQUER, DWAYNE  (contact)

PROJECT_TERMS: analytical tool;anti-cancer research;Authorization documentation;base;cancer genomics;Data;Data Commons;data ecosystem;data framework;data integration;data modeling;data science infrastructure;data sharing;Data Storage and Retrieval;data submission;design;Elements;Environment;experience;genomic data;Genomic Data Commons;genomics cloud;Image;Knowledge;Malignant Neoplasms;Modeling;multimodal data;Ontology;Orphan;Recommendation;repository;Resources;Secure;Semantics;tool;Validation;Vision;Visualization;Vocabulary;working group

PROJECT_TITLE: NCI CBIIT;EXPAND DATA COMMONS


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Hematology;Immunotherapy;Lymphatic Research;Lymphoma;Orphan Drug;Rare Diseases

PI_NAMEs: MITRA, GAUTAM (GEORGE)  (contact)

PROJECT_TERMS: Allogenic;analytical method;Animal Testing;anti-cancer research;Autologous;Biological Assay;Biological Products;Biopsy;Cell Therapy;Cells;Cellular immunotherapy;Clinical;Clinical Research;Clinical Trials;Development;Division of Cancer Treatment and Diagnosis;Evaluable Disease;Exclusion;Freezing;Good Manufacturing Process;Human;Laboratories;Lentivirus;leukemia;Lymphoma;manufacture;manufacturing capabilities;manufacturing process;manufacturing technology;Monitor;Multi-Institutional Clinical Trial;Natural Killer Cells;Needles;novel;participant enrollment;pharmacodynamic biomarker;Pharmacodynamics;Phase;pre-clinical;preclinical study;Process;Production;Program Development;Qualifying;quality assurance;Quality Control;Reference Standards;Regimen;Resources;response;Retroviridae;scale up;Solid Neoplasm;System;T-Lymphocyte;Technology;tumor;Validation;vector

PROJECT_TITLE: Cell-based Immunotherapy Products


NIH_SPENDING_CATS: Networking and Information Technology R&D (NITRD);Sleep Research

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PI_NAMEs: REDLINE, SUSAN  (contact)

PROJECT_TERMS: Bioinformatics;bioinformatics infrastructure;cloud based;Communities;Contracts;Data;data resource;Data Set;Fostering;Future;Goals;meetings;National Heart, Lung, and Blood Institute;Performance;Productivity;programs;Research;Resources;Services;Sleep;tool

PROJECT_TITLE: NATIONAL SLEEP RESEARCH RESOURCE (NSRR)


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Orphan Drug;Pediatric;Pediatric Cardiomyopathy;Racial and Ethnic Minority Health Research;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PI_NAMEs: WU, JOSEPH  (contact)

PROJECT_TERMS: African American population;Area;Asian population;biobank;Blood specimen;Cardiotoxicity;Cardiovascular Diseases;Cardiovascular system;Cell Line;cell type;Cells;Collection;Development;Dilated Cardiomyopathy;Disease;disease model;drug discovery;Drug Screening;Drug toxicity;drug use screening;Ethnic Origin;Exhibits;Genotype;Growth;Hispanic Populations;Human;human induced pluripotent stem cells;Hypertrophic Cardiomyopathy;In Vitro;Individual;Individual Differences;induced pluripotent stem cell;induced pluripotent stem cell derived cardiomyocytes;induced pluripotent stem cell technology;Medical History;Minority;National Heart, Lung, and Blood Institute;novel therapeutic intervention;novel therapeutics;patient response;Patients;Phenotype;Property;Protocols documentation;racial diversity;recruit;regenerative therapy;Research;Research Personnel;Resources;self-renewal;Services;Signal Transduction;Standardization;stem;transcriptome;treatment response

PROJECT_TITLE: BIOREPOSITORY OF HUMAN INDUCED PLURIPOTENT STEM CELLSFORCARDIOVASCULAR DISEASES (BHIPSC-CVD) - TASK AREA B


PROJECT_TERMS: African American population;Area;Asian population;biobank;Blood specimen;Cardiotoxicity;Cardiovascular Diseases;Cardiovascular system;Cell Line;cell type;Cells;Collection;Development;Dilated Cardiomyopathy;Disease;disease model;drug discovery;Drug Screening;Drug toxicity;drug use screening;Ethnic Origin;Exhibits;Genotype;Growth;Hispanic Populations;Human;human induced pluripotent stem cells;Hypertrophic Cardiomyopathy;In Vitro;Individual;Individual Differences;induced pluripotent stem cell;induced pluripotent stem cell derived cardiomyocytes;induced pluripotent stem cell technology;Medical History;Minority;National Heart, Lung, and Blood Institute;novel therapeutic intervention;novel therapeutics;operation;patient response;Patients;Phenotype;Property;Protocols documentation;racial diversity;recruit;regenerative therapy;Research;Research Personnel;Resources;self-renewal;Services;Signal Transduction;Standardization;stem;transcriptome;treatment response

PROJECT_TITLE: BIOREPOSITORY OF HUMAN INDUCED PLURIPOTENT STEM CELLSFORCARDIOVASCULAR DISEASES (BHIPSC-CVD)- TASK A. CORE STUDY OPERATIONS


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Human Fetal Tissue;Mental Health;Neurodegenerative;Neurosciences

ORG_CITY: CORAL GABLES

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PI_NAMEs: STRICKLAND, BRANDON  (contact)

PROJECT_TERMS: Advocacy;Alzheimer's Disease;Autopsy;Brain;brain control;brain tissue;Collection;Communities;Contracts;Disease;Goals;Human;human disease;Mental disorders;National Institute of Child Health and Human Development;National Institute of Drug Abuse;National Institute of Mental Health;National Institute of Neurological Disorders and Stroke;National Institute on Aging;Nervous System Disorder;Neurodevelopmental Disorder;Patients;preservation;Process;Research;Resources;Services;Site;Tissue Banks;Tissues;United States National Institutes of Health

PROJECT_TITLE: THE NIH NEUROBIOBANK BRAIN AND TISSUE REPOSITORY (NBTR) TO PROVIDE SERVICES THAT WILL ACTIVELY ACQUIRE, RECEIVE, STORE, CURATE, PRESERVE, AND DISTRIBU


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Mental Health

PI_NAMEs: GOLDMAN, HOWARD H (contact)

PROGRAM_OFFICER_NAME: FREED, MICHAEL C

STUDY_SECTION: SERV

STUDY_SECTION_NAME: Mental Health Services Study Section[SERV]


ORG_CITY: SILVER SPRING

ORG_NAME: AUTONOMOUS THERAPEUTICS, INC.

PHR: PROJECT NARRATIVE Stochastic fluctuations in gene expression impact cell-fate specification decisions from embryogenesis to viral infection creating barriers for effective treatment interventions. Based on therapeutic precedents in neuroscience that use fluctuations to improve sensorimotor function, this project will identify centralized molecular and cellular mechanisms of noise modulation, that can be therapeutically targeted, in embryonic stem cells (ESCs). The proposed research will lead to development of new broad-spectrum noise modulators, and propel clinical translation of noise-modulating molecules to guide new therapeutic approaches that overcome barriers to precise cell-fate control in diverse mammalian systems.

PI_NAMEs: WEINBERGER, LEOR S (contact)

PROGRAM_OFFICER_NAME: LAWRENCE, DIANE M

PROJECT_TERMS: Address;Affect;Architecture;Attenuated;Award;Bacteria;biological systems;Cell Fate Control;cell fate specification;Cells;Cellular biology;Chemosensitization;circadian;Circadian Rhythms;Clinical;clinical translation;Cytoplasm;Data;Development;Disparate;drug repurposing;effective therapy;Electrophysiology (science);Embryonic Development;embryonic stem cell;Engineering;Enhancers;Evolution;FDA approved;Feedback;Flow Cytometry;Gene Expression;Genes;Genetic;Genetic Transcription;Goals;Heterogeneity;HIV;improved;in vivo;Intervention;knock-down;Knowledge;Literature;Malignant Neoplasms;Mammalian Cell;Maps;mathematical model;Modeling;Molecular;molecular modeling;mutant;Neurosciences;Noise;novel;novel therapeutic intervention;Nuclear Export;Outcome;Pathway interactions;pharmacologic;posttranscriptional;predictive modeling;reactivation from latency;Reporter;Research;Rest;Role;Safety;Science;Sensorimotor functions;Source;Specific qualifier value;Starvation;stem cells;Stress;synergism;System;T-Lymphocyte;Testing;Therapeutic;therapeutic development;Therapeutic Effect;therapeutic target;tool;Transcription Coactivator;transcriptome;Translations;Viral;Virus Diseases;Virus Latency;Work;Yeasts

PROJECT_TITLE: Modulating Stochastic Gene Expression for Cell-fate Control and Therapeutics

STUDY_SECTION: MABS

STUDY_SECTION_NAME: Modeling and Analysis of Biological Systems Study Section[MABS]


ACTIVITY: ZIA

ADMINISTERING_IC: AG

FUNDING_MECHANISM: INTRAMURAL RESEARCH

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Genetics

ORG_NAME: NATIONAL INSTITUTE ON AGING

PI_NAMEs: STERN, MICHAEL  (contact)

PROJECT_TERMS: Aging;Algorithms;analog;Animals;asexual;Attention;Behavior;Biochemical Pathway;Biological;Biological Models;Castes;Code;Collaborations;Computer Simulation;Computer software;Computers;computing resources;Coupled;Cultural Evolution;Dedications;Disadvantaged;Economics;Educational process of instructing;Elements;Environment;Epigenetic Process;Equation;Equilibrium;Event;Evolution;Exclusion;Fishes;fitness;frailty;Free Will;Future;Gambling;Generations;Genes;genetic information;Genetic Programming;Genome;Growth;Hand;Heritability;Human;Human Genome;Husband;imprint;Individual;Inferior;Institution;interest;Life Cycle Stages;life span;Marketing;Mediation;Modeling;models and simulation;Mutation;Mythology;Natural Selections;Nature;network models;Noise;Organism;Ownership;parallelization;Pattern;Population;Probability;Problem Solving;Process;Religion;Reporting;reproductive;Research Personnel;Resources;Risk;Risk Taking;Role;Scientist;Sexual Reproduction;social;Societies;Specific qualifier value;Stratification;Structure;System;Territoriality;Time;trait;United States National Institutes of Health;virtual;virtual reality simulation;Work;Y Chromosome

PROJECT_TITLE: Darwinian Evolution of Virtual Organisms


NIH_SPENDING_CATS: Aging

PI_NAMEs: SOLLOTT, STEVEN  (contact)

PROJECT_TERMS: Aging;Arginine;ATP Hydrolysis;ATP phosphohydrolase;ATP Synthesis Pathway;Automobile Driving;BCL-2 Protein;BCL2 gene;BH3 Domain;Bioenergetics;Bioluminescence;Body Weight;Cations;Cells;Cytoplasm;Cytoprotection;Data;Detection;Development;effective therapy;Elasticity;Elderly;Electron Transport;Electrons;Energy Supply;Enzymes;Exhibits;experimental study;Failure;Family;feature detection;Feedback;Fingers;Guanosine Triphosphate Phosphohydrolases;Heart;Heart failure;Heart Mitochondria;Homeostasis;Individual;inhibitor;Inner mitochondrial membrane;invention;Ions;Ischemia;Lipid Bilayers;Luciferases;Measures;Mechanics;member;Membrane Potentials;metabolic rate;Mitochondria;Mitochondrial Matrix;Modeling;Molecular;molecular recognition;Morphologic artifacts;Motor;novel;Organelles;Osmolalities;Osmosis;Oxidation-Reduction;Oxygen Consumption;Pathology;Performance;Persons;pH gradient;Photons;Phylogenetic Analysis;Physiological;Population;Potassium Channel;Potential Energy;Power stroke;Production;Protein Family;Proteins;proteoliposomes;Proton-Motive Force;Protons;Publications;Pump;Rattus;reconstitution;Regulation;Reperfusion Injury;Respiration;Respiratory Chain;restoration;Rotation;Route;Running;Signal Transduction;single molecule;Source;Specificity;stoichiometry;Stress;Syncope;Techniques;Time;Tissues;Trees;voltage clamp;Water;Workload

PROJECT_TITLE: Control Mechanisms for Matching ATP Supply and Demand in Heart Mitochondria


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

PI_NAMEs: SPENCER, RICHARD  (contact)

PROJECT_TERMS: 3-Dimensional;Age;age related changes;Aging;Alzheimer's Disease;Alzheimer's disease pathology;Amyloid beta-Protein;Anoxia;Bayesian Analysis;Bayesian Method;biomarker development;Body mass index;Brain;Brain imaging;Brain region;Cartilage;Cerebrovascular Circulation;Cholesterol;Clinical;clinical development;Cognition;Cognitive;cognitive ability;Cognitive deficits;cognitive function;Craniocerebral Trauma;Data Analyses;Data Set;Dementia;Demyelinations;density;Deposition;Development;Diffuse;Diffusion;Diffusion Magnetic Resonance Imaging;Echo-Planar Imaging;Edema;Environmental Risk Factor;Equilibrium;Evaluation;Exhibits;experimental study;Free Radicals;Functional disorder;Funding;genetic risk factor;Genotype;Health;Heterogeneity;high dimensionality;Hospitals;human data;human imaging;Image;Impaired cognition;Impairment;improved;in vivo monitoring;Individual;Inflammation;interest;Investigation;Judgment;Laboratories;Language;Least-Squares Analysis;Lesion;Magnetic Resonance Imaging;Maps;Mathematics;Measures;Memory;Methodology;Methods;mild cognitive impairment;Modeling;Morphologic artifacts;Multiple Sclerosis;Myelin;Myelin Sheath;myelination;Nature;Noise;normal aging;Parameter Estimation;Pathway interactions;Pattern;Performance;Phase;Physiologic pulse;pre-clinical;prognostic;progression risk;Protocols documentation;Publishing;Recovery;Relaxation;remyelination;Research;resilience;Role;Scanning;Signal Transduction;Slice;Speed;Stains;Structure;Symptoms;System;T2 weighted imaging;targeted treatment;Techniques;Testing;Therapeutic Intervention;Time;Toxic effect;treatment response;volunteer;Water;white matter;Work

PROJECT_TITLE: Advanced magnetic resonance imaging of the human brain in normative aging, cognitive impairment, and dementia


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences

PI_NAMEs: SEN, RANJAN  (contact)

PROJECT_TERMS: Acute;adaptive immunity;Address;Affect;age effect;age related neurodegeneration;Aging;alpha synuclein;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease related dementia;Antibodies;Behavior;Behavioral;Biological Assay;Brain;brain behavior;Brain Pathology;Cell Line;Cell Physiology;cell type;Cells;Characteristics;ChIP-seq;Chronic;cohort;Defect;Deposition;Development;Disease;Disease Progression;Dose;experimental study;Female;field study;Functional disorder;Funding;Gene Expression;Genes;Genetically Engineered Mouse;Goals;gut inflammation;Hippocampus;Home;human disease;Human Resources;Immune;immune cell infiltrate;Immune response;Immune system;in vivo;Inflammation;Inflammatory;Inflammatory Response;Injections;Interleukin-1;Interleukin-12;Interleukin-6;Kinetics;Laboratories;male;Microglia;Modeling;Monitor;mouse model;Mouse Strains;Mus;Nature;Nerve Degeneration;neuroinflammation;neuropathology;NF-kappa B;old mice;Pathology;Pathway interactions;pharmacologic;Phase;pre-formed fibril;Process;Proteins;Publishing;recruit;Research Project Grants;RNA;Role;Sodium Dextran Sulfate;stem;Synapses;synuclein;synucleinopathy;System;Testing;Therapeutic;Time;TNF gene;transcription factor;transcriptome sequencing

PROJECT_TITLE: ALZHEIMERS RESEARCH PROJECT: Immune and inflammatory interactions in Alzheimer's disease-related dementias


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences

PI_NAMEs: VAN KEUREN-JENSEN, KENDALL  (contact)

PROJECT_TERMS: Affect;Alzheimer's disease pathology;Alzheimer's disease related dementia;Autopsy;Brain;Brain region;cell type;Cells;cingulate cortex;Data;frontal lobe;Genetic Transcription;Goals;Lasers;Occipital lobe;Pathology;Sampling;Series;single cell analysis;single cell genomics;single nucleus RNA-sequencing;transcriptomics

PROJECT_TITLE: Atlasing single nuclei RNA sequencing from postmortem brain in ADRD


PI_NAMEs: GEARHART, PATRICIA J (contact)

PROJECT_TERMS: Antibody Diversity;B-Lymphocytes;Binding;Binding Proteins;Cell Line;Cell Nucleus;Cells;ChIP-seq;chromatin protein;Cleavage Under Targets and Release Using Nuclease;Data;design;Development;DNA;flexibility;Freezing;Genetic Transcription;Histones;Measures;non-histone protein;Nuclear;Procedures;Protocols documentation;Reagent;RNA Polymerase II;Role;Sampling;Signal Transduction;Techniques

PROJECT_TITLE: Roles for Transcription in Antibody Diversity


PROJECT_TERMS: Affinity;Animals;Antibodies;Antibody Diversity;Antibody Response;Antibody Specificity;Antibody titer measurement;antigen binding;Antigens;Aorta;aortic arch;Apolipoprotein E;Arteries;artery occlusion;Atherosclerosis;Autoantibodies;B-Cell Activation;B-cell receptor repertoire sequencing;B-Lymphocytes;Bacteriophages;Binding;Cells;Complex;cytokine;Disease;early onset;Enzyme-Linked Immunosorbent Assay;Fatty acid glycerol esters;Immune system;Immunize;Immunohistochemistry;Immunoprecipitation;Inflammatory;Light;Lipids;Measurement;Mouse Protein;Mus;Necrosis;Proteins;Proteome;Serum;single cell sequencing;western diet

PROJECT_TITLE: Protein Interactions in Antibody Diversity


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Immunization;Neurodegenerative;Neurosciences;Prevention

PROJECT_TERMS: Affinity;age effect;Alzheimer's Disease;animal old age;Antibodies;Antibody Diversity;Antigens;B-Cell Antigen Receptor;B-Lymphocytes;Brain;C57BL/6 Mouse;Cells;Characteristics;Chickens;Disease Progression;disorder prevention;Gamma globulin;Germ Lines;Immune response;Immunization;Immunize;Inflammation;Light;Measurement;Mus;novel;old mice;Pathogenicity;Play;receptor;Recombinant Antibody;reconstruction;Research Project Grants;response;Role;Serum;Severity of illness;single-cell RNA sequencing;Structure of germinal center of lymph node;Time

PROJECT_TITLE: ALZHEIMER'S RESEARCH PROJECT: Effect of Age on Antibody Diversity


NIH_SPENDING_CATS: Aging;Bioengineering;Cardiovascular;Heart Disease;Networking and Information Technology R&D (NITRD)

PROJECT_TERMS: 3-Dimensional;Adrenergic Agents;Algebra;Algorithms;Calcium;Calmodulin;Cell Communication;Cell model;Cell Physiology;Cell Separation;Cell surface;Cells;Classification;Collaborations;Computer Simulation;Computer software;Computers;Copyright;Coupled;Coupling;COVID-19;Data;Dedications;Diffusion;Epidemic;Epidemiology;Event;Green Fluorescent Proteins;Heart;Heart Atrium;Heart Rate;heart rhythm;Heterogeneity;Image;Individual;Ion Channel;Journals;L-Type Calcium Channels;Language;link protein;Location;markov model;Mathematics;Methods;Microscopy;Modeling;multi-scale modeling;Mus;Myocardium;nano;nodal myocyte;novel;old mice;open source;operation;Organelles;Oryctolagus cuniculus;Pacemakers;pandemic disease;parallelization;patch clamp;Phase Transition;Photons;Physics;Physiology;Preparation;Process;Professional counselor;programs;Property;Publishing;reconstruction;Records;Research Personnel;Resolution;Role;Running;Ryanodine Receptor Calcium Release Channel;Scheme;sensor;Shapes;simulation;Sinoatrial Node;Skeletal Muscle;software development;solid state;Spectrometry, Mass, Secondary Ion;Statistical Methods;Structure;theories;Thermodynamics;three-dimensional modeling;Time;tool;Translating;United States National Institutes of Health;Update;virtual;voltage;Work;Writing

PROJECT_TITLE: Stochastic Simulation Of Excitation-contraction Coupling


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Brain Disorders;Cardiovascular;Dementia;Neurosciences

PI_NAMEs: LAKATTA, EDWARD  (contact)

PROJECT_TERMS: Adrenergic Agents;Age;age effect;Age Months;age related changes;Aging;aging biomarker;aging process;Alzheimer's Disease;Animal Model;Animals;Ants;Biological Markers;Blood Vessels;Brain;Cardiac;Cardiovascular system;Cessation of life;Clinical;Clinical Research;cohort;Dementia;Diabetes Mellitus;Echocardiography;Elderly;Electrocardiogram;Endocrine system;Future;Gene Expression Profile;Goals;Healthcare Systems;healthspan;Heart failure;Heart Rate;heart rate variability;Human;Individual;Intervention;Investigation;life span;Malignant Neoplasms;Medical;Mus;neural;Physiological;Population;pre-clinical;programs;quantification of aging;Research Project Grants;social;Societies;Stroke

PROJECT_TITLE: CLINICAL PROJECT:  Biomarkers of Cardiovascular Aging


NIH_SPENDING_CATS: Aging;Bioengineering;Biomedical Imaging;Machine Learning and Artificial Intelligence;Nutrition

PROJECT_TERMS: Adipose tissue;Architecture;Bioenergetics;bone quality;Cartilage;Connective Tissue;design;Diet;dietary restriction;Diffusion;Diffusion Magnetic Resonance Imaging;Fourier Transform;Goals;Health;Human;human subject;improved;in vivo;Investigation;ketogenic diet;Laboratories;Link;Machine Learning;Magnetic Resonance;Magnetic Resonance Imaging;Measures;Metabolic;Methods;Modality;Muscle;Muscle function;muscular structure;Musculoskeletal;Near-Infrared Spectroscopy;neural network;neural network architecture;novel;Older Population;Outcome Measure;primary outcome;Rattus;Research;Sarcomeres;Signal Transduction;Spectroscopy, Fourier Transform Infrared;Tissues;Water;Work

PROJECT_TITLE: Magnetic Resonance Analysis of Connective Tissue and Muscle


NIH_SPENDING_CATS: Aging;Biomedical Imaging;Clinical Research;Physical Activity

PROJECT_TERMS: Aerobic;Aerobic Exercise;Age;age related;age related decline;aged;Aging;Attenuated;Baltimore;Biochemical;Bioenergetics;Exercise;Gait speed;Height;human old age (65+);human subject;Longitudinal Studies;Magnetic Resonance Spectroscopy;Measurement;men;Metabolic;Methods;Muscle;Outcome;Outcome Measure;Oxygen Consumption;Participant;Performance;performance tests;Phosphocreatine;Phosphorus;Physiological;Population;Recovery;sex;Testing;Treadmill Tests;Walking;walking speed;Weight

PROJECT_TITLE: Accurate Quantification in Physiologic Phosphorus MR Spectroscopy


NIH_SPENDING_CATS: Aging;Biomedical Imaging;Brain Disorders;Complementary and Integrative Health;Genetics;Neurosciences;Nutrition;Prevention

PROJECT_TERMS: Alzheimer's disease model;Animals;Area;Base Excision Repairs;Body fat;bone quality;Brain;brain morphology;Caloric Restriction;Cerebellar Ataxia;Cerebrovascular Circulation;Choline;Creatine;Data;Dietary Intervention;dietary restriction;disease model;experimental study;Image;imaging study;interest;Intervention Studies;Investigation;ketogenic diet;knockout animal;Lipids;Magnetic Resonance Imaging;Magnetic Resonance Spectroscopy;Measurement;Measures;Methods;Morphology;mouse model;Mus;Neurons;Participant;Phenotype;preservation;repaired;Rodent Model;Signal Transduction;Single Strand Break Repair;Spectrum Analysis;Structure;Techniques;Transgenic Organisms;Work;XRCC1 gene

PROJECT_TITLE: Magnetic Resonance Imaging and Spectroscopy of Rodent Models of Disease


PROJECT_TERMS: Address;Algorithms;Bayesian Analysis;Bayesian Method;Brain;Cartilage;Clinical;Data;dimension reduction;Dimensions;Equilibrium;experimental study;high dimensionality;Human;human subject;Image;improved;In Vitro;in vivo;Knee;Least-Squares Analysis;Magnetic Resonance Imaging;Maps;marginalization;Measures;Methods;Modeling;Myelin;myelination;Nature;neural network;Noise;novel;novel strategies;Parameter Estimation;Pathway Analysis;Physiologic pulse;Probability;Proteoglycan;Residual state;Signal Transduction;simulation;Spectrum Analysis;Surface;Techniques;Testing;theories;Tissues;Variant;volunteer;Water;Work

PROJECT_TITLE: Multicompartment quantification of tissue in vitro and in vivo with magnetic resonance imaging and spectroscopy


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Clinical Research;Dementia;Frontotemporal Dementia (FTD);Genetics;Human Genome;Lewy Body Dementia;Neurodegenerative;Neurosciences

PI_NAMEs: TRAYNOR, BRYAN  (contact)

PROJECT_TERMS: Acceleration;Adult;Age;aging brain;aging process;Alzheimer's Disease;Alzheimer's disease related dementia;Biology;Clinical;cohort;Complex;computing resources;Congresses;cost;Data;database of Genotypes and Phenotypes;Databases;Defect;Dementia;design;Development;Diagnosis;Disease;disease model;drug development;drug discovery;Drug Targeting;effective intervention;Environment;Etiology;Evolution;Frontotemporal Dementia;frontotemporal lobar dementia amyotrophic lateral sclerosis;Genes;Genetic;Genetic Research;Genetic Risk;Genome;genome sequencing;genomic locus;Goals;Health;Human Genome;improved;insight;Intramural Research Program;Knowledge;Laboratories;Learning;Lewy Body Dementia;Molecular;Nerve Degeneration;Nervous System Disorder;Neurodegenerative Disorders;neurogenetics;Neurologic;Neurosciences;novel;online resource;Onset of illness;Paper;Parkinson Disease;Pathogenesis;Patients;Personal Satisfaction;Phenotype;Publishing;Research;Research Personnel;Research Project Grants;Resources;Risk;risk variant;Role;sequencing platform;Syndrome;targeted treatment;Technology;Testing;therapeutic target;Time;United States National Institutes of Health;Variant;web portal;Work

PROJECT_TITLE: CLINICAL/ALZHEIMERS RESEARCH PROJECT: Genome sequencing of Lewy Body Dementia and Frontotemporal Dementia: a public resource for the study of Alzheimer's disease and related dementias


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Neurodegenerative;Neurosciences;Nutrition

PI_NAMEs: KAPOGIANNIS, DIMITRIOS  (contact)

PROJECT_TERMS: Affective;Age;Aging;aging brain;Alzheimer's Disease;Alzheimer's disease patient;Amyloid deposition;Area;Atrophic;beta-Hydroxybutyrate;Biological Markers;Brain;Brain Chemistry;brain metabolism;Chemistry;Clinical;Clinical Research;Clinical Trials;Cognitive;cognitive performance;Collaborations;Complex;Data;Diet;dietary control;Disease;Enrollment;Esters;fluorodeoxyglucose positron emission tomography;Functional Magnetic Resonance Imaging;gamma-Aminobutyric Acid;Glucose;glucose metabolism;Glutamates;Glutamine;Image;improved;Insulin Resistance;Intermittent fasting;Intervention;Investigation;ketogenesis;Ketone Bodies;Ketones;Knowledge;Machine Learning;Magnetic Resonance Imaging;Magnetic Resonance Spectroscopy;Measurement;Measures;memory encoding;memory retrieval;Metabolic;metabolic abnormality assessment;Metabolism;Methodology;Mitochondria;multiple sclerosis patient;neurochemistry;neuroimaging marker;neurotransmission;novel;novel marker;Oral;Outcome;Participant;Pathogenesis;Play;Positron-Emission Tomography;Process;Proteins;Publishing;Randomized Controlled Clinical Trials;Reporting;Research;Research Personnel;Research Project Grants;response;Rest;Retina;Role;Structure;Synapses;Techniques

PROJECT_TITLE: ALZHEIMERS RESEARCH PROJECT / CLINICAL PROJECT: Brain structure, chemistry and function investigations in aging and Alzheimer's disease using MRI/MRS


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biomedical Imaging;Biotechnology;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Therapeutics and Interventions;Dementia;Emerging Infectious Diseases;Infectious Diseases;Mental Health;Mental Illness;Neurodegenerative;Neurosciences;Nutrition;Obesity;Prevention

PROJECT_TERMS: aging population;aging related disease;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease related dementia;Alzheimer's disease therapeutic;Alzheimer’s disease biomarker;analog;Animal Model;animal tissue;Animals;Anti-Inflammatory Agents;Astrocytes;Autobiography;Biological;Biological Markers;Biological Models;Biological Products;Bipolar Disorder;Blood;Brain;brain health;brain metabolism;Caloric Restriction;Calories;Cell Respiration;Cells;Cellular Metabolic Process;Clinical;Clinical Research;Clinical Trials;Cognitive;Cognitive aging;cognitive performance;cognitive testing;cohort;Collaborations;comparison control;Conduct Clinical Trials;Consumption;Cooperative Research and Development Agreement;COVID-19 impact;Data;Delaware;design;Development;Diagnosis;Diet;Disease;Drug Targeting;Elderly;Energy Metabolism;Episodic memory;Esters;Event;executive function;exenatide;exosome;Family;Flow Cytometry;Fragile X Syndrome;France;Freezing;frontal lobe function;Frontotemporal Dementia;Functional Magnetic Resonance Imaging;Future;Generations;Genetic;Genotype;Genus Hippocampus;glucagon-like peptide 1;Goals;Growth;Health;Health Personnel;Human;human induced pluripotent stem cells;Human Resources;Impairment;improved;in vitro Model;Individual;Inflammatory;infliximab;Insulin;Insulin Resistance;insulin sensitivity;Intake;Intermittent fasting;Intervention;Ketones;Long COVID;Magnetic Resonance Imaging;Martens;Measurement;Measures;Mental Depression;Metabolic;Metabolic syndrome;Metabolism;method development;Methodology;Methods;Microscopy;middle age;Mitochondria;Molecular;Multiple Sclerosis;Multiple System Atrophy;Nerve Degeneration;Nerve Regeneration;Neural Cell Adhesion Molecule L1;neuroimaging;Neurologic;Neurons;neurotransmission;nicotinamide-beta-riboside;novel;Oral;Overweight;Parkinson Disease;Pathogenicity;Pathologic Processes;Patients;peripheral blood;Pharmacodynamics;Plasma;pre-clinical;preclinical study;prenatal;Process;Psychological Impact;Publishing;randomized, controlled study;Research Personnel;Research Project Grants;Resolution;response;response biomarker;Restless Legs Syndrome;Sampling;Schizophrenia;sex;Sphingomyelinase;Structure;Subgroup;synaptic function;Translations;treatment response;Tremor/Ataxia Syndrome;United States Department of Agriculture;Universities

PROJECT_TITLE: ALZHEIMERS RESEARCH PROJECT / CLINICAL PROJECT: Mechanistic and clinical studies in Alzheimer's disease and related disorders


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Bioengineering;Brain Disorders;Cardiovascular;Cerebrovascular;Clinical Research;Dementia;Genetics;Heart Disease;Human Genome;Neurodegenerative;Neurosciences;Prevention;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

PI_NAMEs: LAUNER, LENORE J (contact)

PROJECT_TERMS: actigraphy;Address;Age;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Atherosclerosis;Behavioral;biobank;bioimaging;Biological Markers;biological specimen archives;biological systems;Blindness;Blood Vessels;Body Composition;Brain;Brain Diseases;Brain Pathology;cardiovascular risk factor;Cause of Death;Cerebral small vessel disease;Cessation of life;Characteristics;Classification;Clinical;clinical care;clinical epidemiology;Cognitive;cohort;Complex;Coronary heart disease;Data;data streams;Dementia;design;Diagnosis;Diet;Disease;Enrollment;Environment;Environmental Risk Factor;Epidemiology;Epigenetic Process;follow-up;Follow-Up Studies;Fracture;Funding;Future;Genes;Genetic;genetic epidemiology;genetic risk factor;Genetic Variation;genome wide association study;Genomics;Glucose;Grant;Health;Health Status;Healthcare;hearing impairment;Heart;Heart failure;hemodynamics;Hospitalization;human old age (65+);Image;Impaired cognition;Inflammation;Kidney;late life;Life;Life Cycle Stages;Life Style;Longitudinal Studies;Magnetic Resonance Imaging;Measurement;Measures;member;men;Mental Depression;Metabolic;Microvascular Dysfunction;middle age;multiple omics;Musculoskeletal;National Institute of Neurological Disorders and Stroke;Neurocognitive;neuropsychiatry;novel;Nursing Homes;Obesity;offspring;Older Population;Osteoporosis;Parents;Participant;patient home care;Phenotype;Physical activity;Physiological;Plasma;population based;Predisposition;Prevalence;Process;Prognosis;Prospective Studies;Proteins;Proteomics;Publishing;Recording of previous events;Research;Research Design;Research Support;Rheumatism;Risk Factors;Role;Running;Specimen;Standardization;Structure;System;Testing;trait;Vascular Cognitive Impairment;Vascular Diseases;whole genome;Woman;Work

PROJECT_TITLE: CLINICAL PROJECT:  Age, Gene/Environment Susceptibility Study on the Multi-omics of Aging: A clinical epidemiologic prospective study


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Conditions Affecting the Embryonic and Fetal Periods;Diabetes;Maternal Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Women's Health Research

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

PI_NAMEs: HUGHES, BRENNA  (contact)

PROJECT_TERMS: Adolescent Behavior;adolescent health;Aliquot;Bar Codes;Behavioral;Biological Process;Biometry;Childhood;Chronic Disease;Clinical;cohort;Consent;Continuous Glucose Monitor;Contractor;Contracts;Data;Data Collection;Data Coordinating Center;data exchange;Data Management Resources;design;Development;Devices;Diagnosis;Disease;disorder risk;early life exposure;Electronics;Eligibility Determination;Enrollment;Ensure;Epidemiology;Fetal Development;Fetal Growth;Fetal health;follow-up;Gestational Diabetes;Health;Hospital Records;Human;human subject protection;Individual;individual responsibility;Institution;Label;Laboratories;Lead;Learning;Measurement;Medical;Mission;Monitor;National Institute of Child Health and Human Development;Neonatal;neonatal health;OGTT;Online Systems;Outcome;Participant;Phase;population health;Pregnancy;pregnancy health;Pregnant Women;Prenatal care;prenatal exposure;Procedures;programs;Protocols documentation;Quality Control;Randomized;recruit;repository;Reproduction;Research;Research Methodology;research study;Sampling;Shipping;Site;Standardization;Study Subject;System;Testing;Time;United States National Institutes of Health;Visit;Woman

PROJECT_TITLE: STAGE 2: RECRUITMENT AND FOLLOW-UP FOR THE TIMING OF DELIVERY (TIME) AIM OF THE STUDY OF PREGNANCY AND NEONATAL HEALTH (SPAN) - DUKE UNIV


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Racial and Ethnic Minority Health Research;Women's Health Research

PROJECT_TERMS: Adolescent Behavior;adolescent health;African American;Aliquot;Bar Codes;Behavioral;Biological Process;Biometry;Black American;Childhood;Chronic Disease;Clinical;clinical examination;cohort;Collaborations;Consent;Contractor;Contracts;Couples;Data;Data Collection;Data Coordinating Center;data exchange;Data Management Resources;design;Development;Devices;Disease;disorder risk;Dual-Energy X-Ray Absorptiometry;early life exposure;Eligibility Determination;Ensure;Epidemiology;Ethnic Origin;father role;Fetal Development;Fetal Growth;Fetal health;follow-up;Follow-Up Studies;Genetic;genetic analysis;Health;Hospital Records;Human;human subject protection;Individual;Institution;Label;Laboratories;male;Measurement;Medical;Mission;Monitor;National Institute of Child Health and Human Development;Neonatal;neonatal health;Newborn Infant;Online Systems;Participant;Patient Self-Report;Placenta;population health;Pregnancy;pregnancy health;Pregnant Women;Prenatal care;prenatal exposure;Procedures;programs;Protocols documentation;Quality Control;Race;recruit;repository;Reproduction;Research;Research Methodology;Shipping;System;Third Pregnancy Trimester;ultrasound;United States National Institutes of Health;Visit;Woman

PROJECT_TITLE: STAGE 2 RECRUITMENT AND FOLLOW-UP STUDY OF PREGNANCY AND NEONATAL HEALTH (SPAN) - DUKE UNIV


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Racial and Ethnic Minority Health Research;Women's Health Research

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PI_NAMEs: SILVER, ROBERT  (contact)

PROJECT_TERMS: Adolescent Behavior;adolescent health;African American;Aliquot;Bar Codes;Behavioral;Biological Process;Biometry;Black American;Childhood;Chronic Disease;Clinical;clinical examination;cohort;Collaborations;Consent;Contractor;Contracts;Couples;Data;Data Collection;Data Coordinating Center;data exchange;Data Management Resources;design;Development;Devices;Disease;disorder risk;Dual-Energy X-Ray Absorptiometry;early life exposure;Eligibility Determination;Ensure;Epidemiology;Ethnic Origin;father role;Fetal Development;Fetal Growth;Fetal health;follow-up;Follow-Up Studies;Genetic;genetic analysis;Health;Hospital Records;Human;human subject protection;Individual;Institution;Label;Laboratories;Lead;Learning;male;Measurement;Medical;Mission;Monitor;National Institute of Child Health and Human Development;Neonatal;neonatal health;Newborn Infant;Online Systems;Participant;Patient Self-Report;Placenta;population health;Pregnancy;pregnancy health;Pregnant Women;Prenatal care;prenatal exposure;Procedures;programs;Protocols documentation;Quality Control;Race;recruit;repository;Reproduction;Research;Research Methodology;research study;Shipping;System;Third Pregnancy Trimester;ultrasound;United States National Institutes of Health;Universities;Utah;Visit;Woman

PROJECT_TITLE: STAGE 2: RECRUITMENT AND FOLLOW-UP STUDY OF PREGNANCY AND NEONATAL HEALTH (SPAN) - UNIVERSITY OF UTAH


ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PI_NAMEs: DURNWALD, CELESTE  (contact)

PROJECT_TERMS: Adolescent Behavior;adolescent health;Aliquot;Bar Codes;Behavioral;Biological Process;Biometry;Childhood;Chronic Disease;Clinical;cohort;Consent;Continuous Glucose Monitor;Contractor;Contracts;Data;Data Collection;Data Coordinating Center;data exchange;Data Management Resources;design;Development;Devices;Diagnosis;Disease;disorder risk;early life exposure;Electronics;Eligibility Determination;Enrollment;Ensure;Epidemiology;Fetal Development;Fetal Growth;Fetal health;follow-up;Gestational Diabetes;Health;Hospital Records;Human;human subject protection;Individual;individual responsibility;Institution;Label;Laboratories;Lead;Learning;Measurement;Medical;Mission;Monitor;National Institute of Child Health and Human Development;Neonatal;neonatal health;OGTT;Online Systems;Outcome;Participant;Phase;population health;Pregnancy;pregnancy health;Pregnant Women;Prenatal care;prenatal exposure;Procedures;programs;Protocols documentation;Quality Control;Randomized;recruit;repository;Reproduction;Research;Research Methodology;research study;Sampling;Shipping;Standardization;Study Subject;System;Testing;Time;United States National Institutes of Health;Visit;Woman

PROJECT_TITLE: STAGE 2: RECRUITMENT AND FOLLOW-UP FOR THE TIMING OF DELIVERY (TIME) AIM OF THE STUDY OF PREGNANCY AND NEONATAL HEALTH (SPAN) - UPENN


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Rehabilitation;Social Determinants of Health

PROJECT_TERMS: ableism;Address;Attention;Belief;Clinical Research;Communities;community living;community organizations;Complement;disability;Disabled Persons;Discrimination;Education;Ensure;Event;experience;Funding Opportunities;Health;health disparity;health disparity populations;health equity;Healthcare;improved;Independent Living;Inferior;innovation;Intervention;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;National Institute of Child Health and Human Development;National Institute on Deafness and Other Communication Disorders;Outcome;Output;Phase;Prejudice;Prize;programs;Progress Reports;Reduce health disparities;rehabilitation research;Research;Research Project Grants;Services;social;Time;United States National Institutes of Health;webinar

PROJECT_TITLE: REDUCING HEALTH DISPARITIES FOR PEOPLE WITH DISABILITIES CHALLENGE


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Contraception/Reproduction;Patient Safety;Women's Health Research

ORG_CITY: MORRISVILLE

ORG_NAME: HEALTH DECISIONS, INC.

PI_NAMEs: DART, CLINT  (contact)

PROJECT_TERMS: Adverse event;Amendment;Area;base;Case Report Form;Clinical;Clinical Management;Clinical Practice Guideline;Clinical Research;clinical research site;clinical training;Clinical Trials;Clinical Trials Data Monitoring Committees;Clinical Trials Network;clinically relevant;Collaborations;Confidentiality of Patient Information;Consent Forms;Contraceptive Agents;Contraceptive Devices;contraceptive efficacy;Contraceptive methods;Contracts;Data;Data Analyses;Data Collection;data management;data submission;design;Development;Devices;Documentation;efficacy study;efficacy trial;Eligibility Determination;Enrollment;Ensure;Female of child bearing age;follow-up;Geographic Locations;Good Clinical Practice;Government regulations;Health;Hormones;Human Resources;innovation;Institutional Review Boards;instrument;International;investigator training;Manuals;Manufacturer;meetings;men;Methods;Mission;Monitor;Multi-Institutional Clinical Trial;National Clinical Trials Network;National Institute of Child Health and Human Development;operation;Pamphlets;patient population;Periodicals;population health;Principal Investigator;Procedures;Program Development;protocol development;Protocols documentation;Qualifying;quality assurance;Randomized;Records;recruit;Regulation;Reporting;Research;research clinical testing;Research Personnel;Services;Site;symposium;tool;Training;Update;Vagina;Visit;Woman;Work

PROJECT_TITLE: PROTOCOL FINALIZATION, PROCUREMENT OF REGULATORY APPROVAL, AND COMPLETE START-UP ACTIVITIES FOR THE OVAPRENE VAGINAL DEVICE CLINICAL TRIAL


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Immunization;Infectious Diseases;Patient Safety;Pediatric;Pediatric - AIDS;Prevention;Women's Health Research

ORG_CITY: ROCKVILLE

ORG_NAME: WESTAT, INC.

PI_NAMEs: DRIVER, BARBARA  (contact)

PROJECT_TERMS: Accountability;Acquired Immunodeficiency Syndrome;Administrative Coordination;Adolescent;adolescent woman;AIDS clinical trial group;AIDS prevention;Area;Biological Assay;Birth;Breast Feeding;Child;clinical care;Clinical Protocols;Clinical Research;clinical research site;Clinical Trials;co-infection;Conduct Clinical Trials;Contractor;Counseling;design;Diagnosis;Discipline of Nursing;Disease;Drug Kinetics;Education;Ensure;Epidemiology;Equipment;experience;Exposure to;Goals;high risk;HIV;HIV Infections;HIV therapy;HIV-1;Human;Human Resources;human subject;Immunologics;Infant;Inpatients;Institution;Institutional Review Boards;International Maternal Pediatric Adolescent AIDS Clinical Trials;Laboratories;laboratory facility;Laboratory Technicians;Mediation;Medical;National Institute of Allergy and Infectious Disease;National Institute of Child Health and Human Development;Natural History;Neuropsychology;neutralizing monoclonal antibodies;Office for Human Research Protections;open label;Outpatients;Participant;participant enrollment;patient population;Patients;Perinatal;Pharmaceutical Preparations;Pharmacists;pharmacologic;Phase;phase 1 study;Postpartum Women;Pregnant Women;Prevention;Protocols documentation;Qualifying;recruit;Regulation;Research;Research Activity;Research Personnel;research study;Research Subjects;Safety;safety study;Sampling;Services;Site;Social Work;Specific qualifier value;Specimen;Specimen Handling;subcutaneous;Symptoms;Testing;testing services;transmission process;United States;web site;Work

PROJECT_TITLE: OPEN-LABEL PHASE I STUDY OF THE SAFETY AND PHARMACOKINETICS OF NEUTRALIZING MONOCLONAL ANTIBODIES IN INFANTS EXPOSED TO HIV-I


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Mental Health;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: PROVIDENCE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PI_NAMEs: SILVERSTEIN, MICHAEL  (contact)

PROJECT_TERMS: Address;Area;Beginning of Life;Biological;Birth;Blood;Blood specimen;Characteristics;Child Development;Child Health;Child health equity;Chronic Disease;Clinical;Collaborations;Collection;Data;Data Collection;Data Coordinating Center;design;Development;Diagnostic;dietary;Dietary Assessment;Discrimination;Disease;Disparity;Disparity population;economic disparity;Economics;Electronic Mail;Enrollment;Ensure;Environmental Exposure;Ethnic Origin;Ethnic Population;Fathers;follow up assessment;follow-up;Foundations;Generations;Hair;health disparity;health outcome disparity;Home visitation;Hospitals;Human Development;Individual;Infant;Instruction;Intellectual functioning disability;interest;Intervention;Interview;Interviewer;Investigation;Knowledge;Life;Life Cycle Stages;Life Expectancy;Link;Location;Longitudinal cohort study;Manuals;Maternal and Child Health;Maternal Health;Measures;Mediating;Mental Health;Mission;Monitor;Mothers;National Institute of Child Health and Human Development;Neighborhoods;Neonatal;neurobehavioral;Outcome;outcome disparities;Parents;Participant;participant retention;Patient Recruitments;Patients;Phase;phase 2 study;Phenotype;Play;Population;population health;postnatal;Postpartum Period;Poverty;Pregnancy;Pregnancy loss;prenatal;prenatal health;Preventive;Procedures;Protocols documentation;Psychopathology;Race;racial population;recruit;Reduce health disparities;Reporting;Research;Research Personnel;residence;response;retention rate;Rhode Island;Role;Sampling;Schedule;Self Administration;Self Assessment;sexual minority status;Silicones;social;social disparities;sociodemographics;Socioeconomic Status;socioeconomics;Specific qualifier value;Strategic Planning;Structure;transmission process;Umbilical Cord Blood;United States;Update;Urine;Visit;Woman

PROJECT_TITLE: ENRICHED Study: Completion of Follow-up Assessments for Phase 1 and Prenatal and Neonatal Assessments for Phase 2


ORG_CITY: MENLO PARK

ORG_NAME: SRI INTERNATIONAL

PI_NAMEs: GONG, LEYI  (contact)

PROJECT_TERMS: Active Sites;Affinity;assay development;Binding;Binding Sites;Biochemical;Biological;Biological Assay;Biological Availability;Cellular Assay;Chemicals;computational chemistry;Contraceptive Agents;Contraceptive methods;contraceptive target;Contracts;Decision Making;design;Development;Discipline of obstetrics;Dose;drug development;Generations;Goals;Gynecologic;Health;High Pressure Liquid Chromatography;high throughput screening;Human Resources;improved;in silico;In Vitro;in vivo evaluation;Infertility;instrumentation;Ion Channel;Kilogram;lead series;Ligands;men;Methods;milligram;Mission;Molecular;National Institute of Child Health and Human Development;new chemical entity;Oogenesis;Ovulation;Pediatrics;Peptide Hydrolases;Performance;Perinatology;Pharmaceutical Chemistry;Pharmaceutical Preparations;Pharmacology;Phosphotransferases;Play;preclinical evaluation;Pregnancy;Privatization;Process;Production;Property;protein expression;Protein Isoforms;Qualifying;recombinant peptide;Recombinant Proteins;Reproductive Health;Research;research and development;Research Support;Resources;Role;Safety;screening;Services;Site;small molecule;small molecule libraries;sperm function;Sperm Maturation;Spermatogenesis;Structure;Support Contracts;Testing;Therapeutic;Titrations;Woman;X-Ray Crystallography

PROJECT_TITLE: CHEMICAL SCREENING AND OPTIMIZATION FACILITY – HIGH THROUGHPUT SCREENING for Contraceptive Targets


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Contraception/Reproduction;HIV/AIDS;Infectious Diseases;Prevention;Sexually Transmitted Infections;Women's Health Research

PI_NAMEs: TURPIN, JIM  (contact)

PROJECT_TERMS: Adherence;Anti-Infective Agents;Area;Award;Bacterial Vaginosis;biophysical properties;Chlamydia;Clinical;Clinical Trials Design;Communicable Diseases;Consultations;Contraceptive Agents;Contraceptive methods;Contracts;Data;design;Development;Development Plans;drug action;Drug Combinations;Drug Delivery Systems;drug development;Effectiveness;Ensure;Ethics;Event;Experimental Designs;Extramural Activities;Funding;good laboratory practice;Government;Grant;HIV;HIV/AIDS;Individual;Male Contraceptive Agents;meetings;men;Methods;Monitor;National Institute of Child Health and Human Development;participant safety;pathogen;Pattern;Perception;Pharmaceutical Preparations;Pharmacology;Phase;Phase I Clinical Trials;Policies;pre-clinical;preclinical development;Pregnancy;pregnancy prevention;prevent;Prevention;Procedures;product development;Program Development;Property;Protocols documentation;Recommendation;Reporting;reproductive;Research;research facility;Research Personnel;Risk Assessment;Safety;Services;sexual and reproductive health;Sexually Transmitted Diseases;Technology;Toxicology;U-Series Cooperative Agreements;uptake;virology;Woman;Work

PROJECT_TITLE: SCIENTIFIC AND TECHNICAL CONSULTING SERVICES FOR PRE-CLINICAL AND CLINICAL MULTIPURPOSE PREVENTION TECHNOLOGIES of Contraception Research


NIH_SPENDING_CATS: HIV/AIDS;Immunization;Prevention;Vaccine Related;Vaccine Related - AIDS

PROJECT_TITLE: Feasibility for Development of a Liposome/LNP Displaying an HIV Env Trimer Protein and Containing/Incorporating an mRNA


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics;HIV/AIDS;Immunization;Infectious Diseases;Nanotechnology;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: KENSINGTON

ORG_NAME: ADVANCED BIOSCIENCE LABORATORIES, INC.

PI_NAMEs: FOUTS, TIMOTHY R (contact)

PROJECT_TERMS: Address;Antigens;Area;Binding;Contracts;Coupled;Development;Documentation;Feasibility Studies;flexibility;Goals;HIV;HIV envelope protein;HIV vaccine;Investigational Drugs;Lipids;Liposomes;manufacturability;Membrane;Messenger RNA;nanoparticle;National Institute of Allergy and Infectious Disease;Phase;pre-clinical;Preclinical Testing;Process;product development;Production;programs;Property;Proteins;Reporter Genes;research clinical testing;scaffold;Services;vaccine development;vaccine platform;Vaccines


ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: RESEARCH CENTERS

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Digestive Diseases;Genetics;Human Genome;Orphan Drug;Pancreatic Cancer;Rare Diseases

ORG_CITY: OKLAHOMA CITY

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PHR: Project Narrative: Acquired resistance to therapy contributes to poor survival outcomes in cancer patients. The primary objective of this U54 application is to establish a successful and self-sustaining ARTNet Center for Pancreatic Cancer (ACPC) to explore novel mechanisms and combination therapies to target acquired resistance in pancreatic cancer. We will collaborate and work closely with other ARTNet centers, coordinating center, and the National Cancer Institute to provide novel mechanistic insights and translational opportunities to target therapy resistance with the long-term goal of improving overall patient survival.

PI_NAMEs: SINGH, PANKAJ KUMAR (contact)

PROGRAM_OFFICER_NAME: BERA, TAPAN K

PROJECT_TERMS: Automobile Driving;cancer cell;Cancer Patient;Cell Compartmentation;Cells;Chemoresistance;chemotherapy;Coculture Techniques;Collaborations;Combination Drug Therapy;Combined Modality Therapy;Complex;cytokine;Diagnosis;Disease;Drug resistance;Fibroblasts;Fluorouracil;gemcitabine;Gene Expression;Genomics;Goals;Human;human model;Immune;improved;insight;intercellular communication;irinotecan;Laboratories;Leucovorin;Macrophage;Malignant neoplasm of pancreas;Malignant Neoplasms;Metabolic;Metabolic Pathway;metabolic profile;Metabolism;metabolome;metabolomics;Methods;Modeling;National Cancer Institute;novel;Organoids;oxaliplatin;Paclitaxel;pancreatic cancer cells;pancreatic cancer model;pancreatic cancer patients;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;paracrine;patient response;Patients;Phenotype;Regulation;Resistance;Resistance development;response;Stromal Cells;survival outcome;targeted treatment;therapeutically effective;therapy resistant;three dimensional cell culture;transcriptome;transcriptomics;translational potential;treatment response;tumor microenvironment;Tumor-associated macrophages;Work

PROJECT_TITLE: Metabolic regulation of FOLFIRINOX acquired resistance in pancreatic cancer


ED_INST_TYPE: GRADUATE SCHOOLS

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

ORG_CITY: COLLEGE STATION

ORG_DEPT: PSYCHOLOGY

ORG_NAME: TEXAS A&M UNIVERSITY

ORG_STATE: TX

PHR: PROJECT NARRATIVE Alzheimer’s disease (AD) is currently an incurable and debilitating disease whose pathologies begin to accumulate in the brain decades before cognitive symptoms appear, indicating the importance of identifying individuals who are at risk of developing AD earlier in the aging process when they are still cognitively unimpaired. The current project aims to characterize brain connectome-based biomarkers of cognitive changes in aging and vulnerability to AD in cognitively unimpaired individuals, and examine the role of social disadvantage in contributing to risk for cognitive decline and AD. Findings from this project would benefit public health by informing not only risk prediction of AD, but also the development of targeted intervention and therapeutic treatment to promote healthy aging and prevent AD.

PI_NAMEs: TANG, RONGXIANG  (contact)

PROGRAM_OFFICER_NAME: MARTIN, DAMALI

PROJECT_TERMS: Address;African American population;Age-associated memory impairment;Aging;aging brain;aging process;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease related dementia;Alzheimer's disease risk;Alzheimer’s disease biomarker;Amyloid beta-42;Amyloid beta-Protein;Biological;Biological Markers;Biological Process;Brain;Brain Mapping;Cognition;Cognitive;Cognitive aging;cognitive change;cognitive function;cognitive neuroscience;cognitive performance;cognitive testing;Communication;Computer Analysis;connectome;cost effective;Data Set;Deterioration;Development;Disease;Disparity population;Early identification;Ethnic Origin;Ethnic Population;Foundations;Future;Goals;Grant;Health;health disparity;healthy aging;Hispanic Populations;Impaired cognition;improved;indexing;Individual;Intervention;K-Series Research Career Programs;Light;Link;Longitudinal Studies;low socioeconomic status;Magnetic Resonance Imaging;Measures;Mentors;Methodology;Methods;Mexican Americans;multimodal neuroimaging;Nerve Degeneration;Neurobehavioral Manifestations;neurofilament;neuroimaging;neuroimaging marker;Neurosciences;Not Hispanic or Latino;older adult;Pathology;Plasma;Population Heterogeneity;Positron-Emission Tomography;Prevalence;prevent;programs;Property;Public Health;Race;racial minority population;Research;Research Personnel;Research Project Grants;Risk;Risk Factors;risk prediction;Role;segregation;social disparities;Socioeconomic Status;socioeconomics;tau Proteins;tau-1;Therapeutic;Training;Translating;Twin Studies;Variant;Vietnam;Visualization;Vulnerable Populations;Work

PROJECT_TITLE: Brain Connectomics of Cognitive Aging and Vulnerability to Alzheimer's Disease

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development For Early Career Investigators Study Section [AGCD-2]


ORG_CITY: WASHINGTON

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: GEORGE WASHINGTON UNIVERSITY

ORG_STATE: DC

PHR: Project Narrative The AIDS and Cancer Specimen Resource (ACSR) will supply biospecimens and clinical data to individuals investigating People Living with HIV and cancer. It also supports the AIDS Malignancy Consortium (AMC) by providing biorepository support for clinical trials in the United States, Sub-Saharan Africa, and Latin America.

PI_NAMEs: BETHONY, JEFFREY MICHAEL (contact);COGHILL, ANNA ;RIMSZA, LISA

PROGRAM_OFFICER_NAME: LIDDELL HUPPI, REBECCA

PROJECT_TERMS: Accountability;Accreditation;Achievement;Acquired Immunodeficiency Syndrome;Adult;Africa South of the Sahara;African American;Aging;AIDS Malignancy Consortium;AIDS related cancer;anti-cancer research;antiretroviral therapy;Arizona;biobank;Biological;Biological Specimen Banks;Blood specimen;Brazil;Cancer Center;cancer risk;cancer specimen resource;Caribbean region;Cessation of life;Clinic;Clinical Data;Clinical Trials;Collaborations;Collection;college;Complex;Data;Data Commons;Data Pooling;Data Set;design;Eligibility Determination;Equipment and supply inventories;Equity;Exhibits;experience;Funding;General Population;Goals;HIV;HIV Infections;HIV/AIDS;Human;improved;Incidence;Individual;Infection;Informatics;Latin America;Latin American;Leadership;Link;Liquid substance;Malignant Neoplasms;Medicine;member;men;National Cancer Institute;novel;pandemic disease;Participant;Patients;Persons;Population;preservation;programs;Protocols documentation;Research Personnel;Research Support;Residual state;Resources;response;Sample Size;Sampling;Secure;Site;Source;South Africa;Specimen;Standardization;Structure;System;Testing;Time;Tissue Sample;trend;Tumor Tissue;United States;United States National Institutes of Health;Universities;Washington;web portal


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

ORG_NAME: DANA-FARBER CANCER INST

PI_NAMEs: BURNS WHITE, KAREN ANN (contact)

PROGRAM_OFFICER_NAME: WALI, ANIL

PROJECT_TERMS: Address;American;Area;behavioral and social science;Behavioral Sciences;Black Populations;Boston;Cancer Center;cancer health disparity;career;career development;Color;Communication;Communities;COVID-19 pandemic;Dana-Farber Cancer Institute;design;Development;Disabled Persons;Discipline;Discipline of Nursing;Disparity;Doctor of Philosophy;Education;education research;Educational Status;Enrollment;Ethnic Population;evidence base;experience;Faculty;Fellowship;Fostering;Genomics;Graduate Degree;graduate school;graduate student;Grant;Group Affiliation;Growth;Health;health communication;Health Disparities Research;health disparity;Healthcare;improved;Individual;Infrastructure;innovation;Institutional Racism;interest;Intervention;Investments;Knowledge;Latinx;Low Income Population;Malignant Neoplasms;Manuscripts;Massachusetts;Mentors;Methods;multidisciplinary;Native Americans;NCI Center for Cancer Research;outreach;Peer Review;personalized cancer therapy;Phase;physical science;Population;Population Heterogeneity;Postbaccalaureate;Postdoctoral Fellow;Preparation;Process;Productivity;programs;Publications;racial population;Research;research and development;Research Design;Research Personnel;Research Project Grants;research study;Science;Science Enrichment;Scientific Advances and Accomplishments;Scientist;skills;Students;success;Training;undergraduate student;Underrepresented Populations;Underrepresented Students;Universities;Work

PROJECT_TITLE: Research Education Core


NIH_SPENDING_CATS: Cancer

ORG_CITY: PETERSBURG

ORG_NAME: VIRGINIA STATE UNIVERSITY

ORG_STATE: VA

PI_NAMEs: FAISON, MILTON O (contact);ROBERTS, DANIEL M.

PROGRAM_OFFICER_NAME: RODRIGUEZ, LARITZA MARIA

PROJECT_TITLE: SUCCEED Administrative Core


ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: The world is in need of an effective HIV/AIDS vaccine, and the cytomegalovirus (CMV) vector-based HIV/SIV vaccine featured in our studies is highly efficacious and durable to uniquely mediate viral “replication arrest” efficacy in the Rhesus Macaque-SIV model. Vaccine immunity is mediated by unconventional MHC-E-restricted CD8+ T cell responses and induction of IL-15, which correlate with vaccine protection. The work proposed in this application will reveal the molecular mechanisms of immune programming by the CMV-based vaccine and IL- 15 actions to inform human testing of this vaccine concept in ongoing and future phase I/II trials.

PI_NAMEs: GALE, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: SINGH, ANJALI

PROJECT_TITLE: Mechanisms programming Protective Immunity from RhCMV-SIV Vaccine and IL-15 actions


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Aphasia;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Burden of Illness;Clinical Research;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Neurosciences;Pediatric;Prevention;Rehabilitation;Social Determinants of Health

PHR: Communication problems or disorders of voice, speech, and language (VSL) are primary mission areas of the National Institute on Deafness and Other Communication Disorders (NIDCD), NIH.  Disorders involving VSL can have an overwhelming effect on an individual’s health and quality of life. These disorders affect people of all ages with or without hearing impairment, including children with autism, those who stutter, and adults with aphasia or speech disorders. The functions, skills, and abilities of voice, speech, and language are related.  It is important to recognize functional health impairments, including delayed childhood development, and seek early evaluation by health care professionals, e.g., early interventionists and speech-language pathologists (SLP), to identify the problem(s) and select effective treatment(s). The information obtained will become a Public Use dataset approximately six-months following the end of data collection and, hence, available for analysis and dissemination by research investigators and for other purposes, including providing updates to track progress in achieving national objectives formulated for this decade’s Sensory and Communication Disorders topic area of Healthy People 2030.

PROJECT_TERMS: Adult;adverse outcome;Affect;Age;American;Aphasia;Area;autistic children;Biological;Categories;Censuses;Child;Childhood;Clinical;Communication;Communication difficulty;Communication Disability;Communication impairment;Communities;Community Surveys;Data Collection;Data Set;Deglutition;Deglutition Disorders;Development;disability;Disease;Economics;Education;effective therapy;Epidemiology;epidemiology study;Ethnic Population;Evaluation;Family;Geographic Locations;Health;health care availability;health care service;Health Professional;Health Status;Healthcare;hearing impairment;Housing;Impaired health;Income;Individual;Intervention;intervention program;Interview;Language;Language disability;Language Disorders;Life;Medical;Mission;National Health Interview Survey;National Institute on Deafness and Other Communication Disorders;Occupational;Pathologist;Persons;Policy Maker;Population;population survey;Prevalence;prevent;Provider;Quality of life;racial population;Research;Research Personnel;Risk;Risk Factors;risk mitigation;Schools;Sensory Disorders;Services;Severities;sex;skills;social;Social Interaction;sociodemographic factors;sociodemographics;Speech;Speech Disorders;Speech-Language Pathology;Stuttering;Surveys;United States;United States National Center for Health Statistics;United States National Institutes of Health;Update;Voice;Voice Disorders;Work

PROJECT_TITLE: CDC-NCHS-NHIS Voice, Swallowing, Speech, and Language Components


NIH_SPENDING_CATS: Aging;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Infectious Diseases;Menopause;Women's Health Research

ORG_CITY: FREDERICK

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;AIDS clinical trial group;Alendronate;Biological Products;Cell Aging;Clinical;Clinical Research;Clinical Trials;Contracts;Dasatinib;Funding;HIV;HIV-1;HIV/AIDS;improved;menopausal hormone therapy;National Institute of Allergy and Infectious Disease;Pharmacologic Substance;pilot trial;Placebos;programs;Schedule;Services;Woman

PROJECT_TITLE: NIAID Clinical Products Center (CPC): HIV/AIDS Study Support


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Neurosciences

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative The goal of the Center for Innovative NeuroTech Advancement (CINTA) is to rapidly transform emerging technologies into commercially viable, clinically focused solutions for disorders of the nervous system as a hub under the NIH Blueprint MedTech: Incubator Hubs program. CINTA will support the advancement of neurotechnology solutions by adapting and improving upon the proven model that CIMIT developed and implemented for RADx Tech to accelerate promising neurotechnologies that address critical areas of unmet needs in the diagnosis and treatment of nervous system disorders to human-grade prototypes. CINTA plans to find, fund, facilitate, and accelerate 15 projects per year through this program.

PI_NAMEs: BONATO, PAOLO ;SCHACHTER, STEVEN C. (contact)

PROGRAM_OFFICER_NAME: WOLFSON, MICHAEL

PROJECT_TERMS: Acceleration;Address;Area;Clinical;Collaborations;commercialization;Committee Members;Communities;Companions;Complex;Development;Diagnosis;Emerging Technologies;Ensure;Environment;equity, diversity, and inclusion;Evaluation;experience;Funding;Goals;Health Technology;Healthcare;Human;improved;Incubators;Infrastructure;innovation;Institution;interest;International;Investments;Laboratories;Leadership;manufacture;Medical;Medicine;Modeling;multidisciplinary;Needs Assessment;Nervous System Disorder;neurological rehabilitation;neurotechnology;Outcome;outreach;Performance;Process;programs;prototype;RADx Tech;Research;Research Personnel;Resources;Risk;Science;sharing platform;success;technological innovation;Technology;tool development;Training;Translational Research;United States National Institutes of Health;virtual technology;web site

PROJECT_TITLE: Center for Innovative NeuroTech Advancement - CINTA


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Congenital Structural Anomalies;Data Science;Pediatric;Prevention

ORG_CITY: SEATTLE

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE The DS-CHANGE training program builds upon long-standing collaborations between Kwame Nkrumah University of Science and Technology (KNUST), the University of Washington (UW), Seattle Children’s Hospital, and the non-profit Smile Train. We propose to (i), develop a cadre of trained Ghanaian scientists who can use data science approaches to tackle prominent child health problems, (ii) build faculty and institutional capacity for data science at KNUST, and (iii) develop competencies to ensure Ghanaian biomedical data science teams work effectively and synergistically. Trainees will develop skills and acquire experience with real world data science problems that address 3 of the top 10 ten causes of child death and disability in Ghana: malaria, injury and congenital malformations.

PI_NAMEs: AMOAKO-YIRENKYI, PETER ;DONKOR, PETER ;MCKINNEY, CHRISTY MICHELLE (contact)

PROGRAM_OFFICER_NAME: POVLICH, LAURA

PROJECT_TERMS: Active Learning;biomedical data science;Biometry;certificate program;Cessation of life;Child;Child Health;Clinical Informatics;Collaborations;Complex;computer science;Congenital Abnormality;congenital anomaly;Data Science;Data Scientist;disability;Discipline;Doctor of Philosophy;Educational process of instructing;Effectiveness;Epidemiology;evidence base;externship;Faculty;Funding;Ghana;Goals;graduate student;Health;Injury;Institution;institutional capacity;Malaria;Mathematics;Mentors;Methodology;Methods;orofacial cleft;Parasitology;Pediatric Hospitals;Pediatrics;Positioning Attribute;programs;Qualifying;Research;Research Institute;Science;Scientist;Smiling;Technology;Training;Training Programs;Universities;Washington

PROJECT_TITLE: Data Science for Child Health Now in Ghana (DS-CHANGE)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-C(70)]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Emerging Infectious Diseases;HIV/AIDS;Immunization;Infectious Diseases;Orphan Drug;Prevention;Rare Diseases;Tuberculosis;Tuberculosis Vaccine;Vaccine Related

ORG_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

PROJECT_TERMS: Acceleration;Acquired Immunodeficiency Syndrome;Acute;Basic Science;Biological Assay;cell killing;Clinical Research;cohort;Developing Countries;Development;Disease remission;Dose;Epidemic;HIV;HIV Infections;HIV vaccine;HIV/AIDS;innovation;Intervention;Leadership;manufacture;Medical Research;Military Personnel;Monitor;monoclonal antibody production;National Institute of Allergy and Infectious Disease;pharmacologic;pre-clinical;preclinical development;Program Research Project Grants;programs;Reporting;Research;research and development;Research Institute;T-Lymphocyte;Therapeutic Research;Toxic effect;Tuberculosis;vaccine development;Vaccine Research;Vaccines;Viral

PROJECT_TITLE: HIV Vaccine Research and Development - NIAID DAIDS Therapeutics Research Program


ADMINISTERING_IC: NS

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences

ORG_CITY: EL CERRITO

ORG_NAME: MAGNETIC TIDES, INC.

PHR: Project Narrative We have recently developed a new non-invasive brain stimulation (NIBS) system, kilohertz transcranial magnetic perturbation (kTMP) that opens up a new experimental space for safely modulating neural excitability in targeted areas of the human brain. This project will characterize the broad parameter space of kTMP in terms of tolerability and efficacy in healthy individuals. The results from this work will set the stage for full-fledged clinical trials in patients with neurological disorders such as stroke or spinal cord injury, two areas in which NIBS methods show promise as tools to facilitate neurorehabilitation.

PI_NAMEs: LABRUNA, LUDOVICA  (contact)

PROGRAM_OFFICER_NAME: CAPORELLO, EMILY LAURA

PROJECT_TERMS: Acoustics;Amplifiers;Area;Auditory;Basic Science;Behavior;Behavioral;Behavioral Assay;Brain;Cephalic;clinical application;Clinical Trials;cognitive neuroscience;Communities;Coupling;design;Detection;Devices;Double-Blind Method;Earplug;efficacy evaluation;electric field;Electric Stimulation;Electroencephalography;expectation;experimental study;falls;flexibility;Frequencies;Funding;Goals;Grant;Human;Individual;Institution;Institutional Review Boards;interest;Intervention;Lead;Learning;Literature;magnetic field;Magnetism;Measures;Membrane Potentials;Mental Depression;Methods;Motor Cortex;Motor Evoked Potentials;Nervous System Disorder;neural;Neurologic;neurological rehabilitation;Neurons;noninvasive brain stimulation;Occipital lobe;Pain;Participant;Patients;Physiologic pulse;Physiological;Physiology;Pilot Projects;Population;Protocols documentation;Rest;Risk;Safety;Scalp structure;Sensory;Signal Transduction;sound;Specificity;Spinal cord injury;Stroke;stroke rehabilitation;stroke therapy;Surface;Syncope;System;Tactile;Testing;Time;tool;Transcranial magnetic stimulation;translational applications;vibration;voltage;Work

PROJECT_TITLE: Exploring the Parameter Space of High Frequency Magnetic Perturbation in Manipulating Neural Excitability and Plasticity.


FUNDING_MECHANISM: SBIR/STTR CONTRACTS

NIH_SPENDING_CATS: Bioengineering;Cancer;Cervical Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Radiation Oncology;Social Determinants of Health;Women's Health Research

ORG_CITY: AUSTIN

ORG_NAME: VELOXAI LLC

PI_NAMEs: GHIMIRE, KANCHAN  (contact)

PROJECT_TERMS: Affect;Algorithms;Brachytherapy;Cancer Burden;Clinical;commercialization;Computer software;Disease;Dose Rate;Ensure;High-Dose Rate Brachytherapy;Human;improved;innovation;Institution;low and middle-income countries;Malignant neoplasm of cervix uteri;novel;Phase;Process;Radiation therapy;Recurrence;research and development;Resource-limited setting;Resources;Small Business Innovation Research Grant;software systems;standard of care;Treatment outcome;treatment planning;usability;validation studies;Vendor

PROJECT_TITLE: SBIR PHASE II, TOPIC 431: AUTOMATIC TREATMENT PLANNING OF CERVICAL CANCER HIGH-DOSE RATE BRACHYTHERPAY FOR LOW-RESOURCE SETTINGS.


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: STONY BROOK

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

ORG_STATE: NY

PHR: Urine cadmium and risk of fracture and bone loss Narrative Mechanistic experiments and cross-sectional epidemiologic studies have linked cadmium to low bone mineral density, osteoporosis, and fracture; however, currently lacking are large prospective epidemiologic studies. We propose to leverage existing samples and data from the two largest prospective US osteoporosis cohort studies to perform an in-depth investigation of cadmium, bone loss, and fractures. These studies promise to transform the field of Cd-bone research and have high potential to impact policy decisions in the US and globally.

PI_NAMEs: MELIKER, JAYMIE R (contact)

PROGRAM_OFFICER_NAME: CHEN, FAYE H

PROJECT_TERMS: adjudication;Affect;Age;aged;Aging;Agreement;Behavioral;Biological Markers;bone;Bone Density;bone loss;bone metabolism;Bone Resorption;Bone structure;bone turnover;Cadmium;Cell Culture System;Clinic Visits;Clinical Data;clinical research site;cohort;Cohort Studies;cost;cost effective;Cotinine;Creatinine;Cross-Sectional Studies;Cyclophosphamide;Data;Diet;dietary;Dual-Energy X-Ray Absorptiometry;Elements;Environment;Environmental sludge;Epidemiology;epidemiology study;Etiology;Excretory function;experimental study;Female;Femur;Fertilizers;Foundations;Fracture;fracture risk;Half-Life;Health;Heavy Metals;hip bone;Human;human old age (65+);Individual;Industrialization;inorganic phosphate;insight;Intake;International;Investigation;Kidney;Link;Longterm Follow-up;male;Measures;Mediating;Mediation;men;Minerals;Morbidity - disease rate;mortality;National Health and Nutrition Examination Survey;Neck;never smoker;novel;Odds Ratio;Organ Culture Techniques;Osmolalities;Osteogenesis;Osteoporosis;osteoporosis with pathological fracture;Persons;Policies;Population;Population Attributable Risks;Prevalence;prospective;Prospective Studies;Public Health;Random Allocation;recruit;Reporting;Research;Research Design;Sampling;Scanning;Serum;Sewage;sex;skeletal;skeletal tissue;Smoking;Smoking History;Soil;Source;Time;Toxic effect;United States;urinary;Urine;Vertebral column;Visit;Woman;working group

STUDY_SECTION: NAME

STUDY_SECTION_NAME: Neurological, Aging and Musculoskeletal Epidemiology Study Section[NAME]


ADMINISTERING_IC: CL

IC_NAME: CLINICAL CENTER

ORG_NAME: CLINICAL CENTER

PI_NAMEs: DE GIORGI, VALERIA  (contact)

PROJECT_TERMS: American;anti-hepatitis C;Anti-viral Agents;Antibodies;Biopsy;Blood Donations;Blood donor;Blood Transfusion;chronic infection;Cirrhosis;Clinic;Clinical;cohort;Counseling;curative treatments;Data Analyses;Development;Donor Selection;Enrollment;Follow-Up Studies;Fright;Goals;Hepatitis C;Hepatitis C virus;Immune response;Infection;Intravenous;Liver;Liver Fibrosis;Longterm Follow-up;National Institute of Diabetes and Digestive and Kidney Diseases;Natural History;Notification;Outcome;Patients;Pharmaceutical Preparations;Phase;Positive Test Result;Prospective Studies;Protocols documentation;Publishing;Red Cross;repository;Resources;Risk Factors;RNA;Sampling;Serum;Services;Testing;Time;Toxic effect;transmission process;treatment response;Uncertainty;United States National Institutes of Health;Viral;Viral Load result;viral transmission;Visit

PROJECT_TITLE: A Prospective Study Of Anti-hepatitis C Virus Positive Blood Donors


PI_NAMEs: FLEGEL, WILLY  (contact)

PROJECT_TERMS: Alleles;Altitude;blood group;Blood Group Antigens;Blood specimen;Blood typing procedure;Communicable Diseases;Complementary DNA;DNA;Environmental Risk Factor;Erythrocytes;Ethiopian;Ethnic Population;Exposure to;Future;Genes;genetic analysis;Genetic Variation;Genotype;Human;immunohematology;insight;Malaria;Methods;Molecular;next generation sequencing;novel;Oxygen;Phenotype;Plasma;Population;population based;pressure;Prevalence;Sampling;Serology;Shapes;Sickle Cell Anemia;United States National Institutes of Health

PROJECT_TITLE: Molecular Immunohematology in Ethiopian Sub-populations


PI_NAMEs: MARIC, IRINA  (contact)

PROJECT_TERMS: alanine aminopeptidase;Antibodies;Biological Markers;Blood;Body System;Bone Marrow;Bone Marrow Aspiration;candidate marker;Cardiac;Categories;CD34 gene;CD44 gene;Cell Separation;Cellular Morphology;Chromosomes;Classification;Clinical;cohort;Consensus;Data;Development;Diagnosis;Disease;Disseminated eosinophilic collagen disease;Endomyocardial Fibrosis;eosinophil;Eosinophilia;Etiology;Evaluation;evidence based guidelines;FCGR3B gene;Flow Cytometry;Fluorescence;Fluorescent in Situ Hybridization;fusion gene;Gene Fusion;Heart Transplantation;Hematological Disease;Hematopoietic;HLA-DR Antigens;Human;ICAM1 gene;IL5RA gene;Imatinib;Immunophenotyping;inhibitor;International;interstitial;ITGAM gene;ITGAX gene;Laboratories;Laboratory Study;lymphoid neoplasm;Medical;Metamyelocyte;Molecular;Morbidity - disease rate;mortality;Mutation;Myelocyte;Myelogenous;Myeloproliferative disease;National Institute of Allergy and Infectious Disease;Neoplasms;Neurologic;new therapeutic target;novel;Pathogenicity;Pathology;patient population;Patients;Pattern;PDGFRA gene;PDGFRB gene;Play;Population;Preparation;Prognosis;Progranulocytes;Protein Tyrosine Kinase;Proto-Oncogene Protein c-kit;PTPRC gene;Rare Diseases;Reporting;Reverse Transcriptase Polymerase Chain Reaction;Role;Sampling;SELL gene;sialic acid binding Ig-like lectin;Surface;Systemic Mastocytosis;Testing;Time;treatment response;World Health Organization

PROJECT_TITLE: Laboratory Assessment of Patients with Hypereosinophilic Syndrome


PROJECT_TERMS: Adult;Aftercare;Allergic Disease;Biological Assay;Body System;Bone Marrow;Caring;Case/Control Studies;Childhood;Classification;Clinical;cohort;Collaborations;Cutaneous Mastocytosis;Data;detection assay;Diagnosis;Disease;Disease stratification;disease-causing mutation;Evaluation;Flow Cytometry;Gene Frequency;General Population;genetic association;genetic variant;Genome;Genotype;Healthcare Systems;Heterogeneity;Heterozygote;Histopathology;Idiopathic anaphylaxis;IL2RA gene;Immunohistochemistry;improved;Individual;Indolent Systemic Mastocytosis;Inherited;International;Laboratories;mast cell;mastocytosis;Methodology;Molecular;Molecular Diagnosis;Morphology;Mutation;National Institute of Allergy and Infectious Disease;neoplastic cell;novel;Patients;pediatric patients;peripheral blood;Prevalence;Prospective Studies;Proto-Oncogene Protein c-kit;Proto-Oncogenes;Rare Diseases;Receptor Protein-Tyrosine Kinases;Registries;Reporting;Research Personnel;Retrospective Studies;screening;Sensitivity and Specificity;Serum;Skin;Somatic Mutation;Specificity;Standardization;standardized care;symptomatology;Symptoms;Systemic Mastocytosis;Testing;Time;Tissues;Tryptase;Variant

PROJECT_TITLE: Laboratory Assessment of Patients with Systemic Mastocytosis


PROJECT_TERMS: Accounting;Aftercare;Antibody Response;antigen binding;Antigens;aspirate;B-Lymphocytes;beta-Chemokines;Blood;Bone Marrow;Bone marrow biopsy;Bone Marrow Cells;Cell Maturation;Cells;chemokine receptor;chimeric antigen receptor;Clinical;Clinical Trials;Collaborations;Color;cytokine release syndrome;Diagnosis;Disease;Evaluable Disease;first-in-human;Flow Cytometry;Functional disorder;Hematologic Neoplasms;Hematological Disease;Human;Immunoglobulins;Immunohistochemistry;Immunophenotyping;In complete remission;Infusion procedures;insight;Investigation;Light;Malignant Neoplasms;Molecular;Multiple Myeloma;neoplastic;Pathogenesis;Patients;peripheral blood;Plasma Cells;Prognosis;Progression-Free Survivals;Receptor Cell;Refractory;Relapse;Research Personnel;Serum;Serum Markers;single-cell RNA sequencing;Staging;T-Lymphocyte;Time;treatment response;United States;United States National Institutes of Health;Urine

PROJECT_TITLE: Bone Marrow Histopathological Changes in Neoplastic and Non-Neoplastic Diseases


NIH_SPENDING_CATS: Aging;Biodefense and Related Countermeasures;Bioengineering;Emerging Infectious Diseases;Infectious Diseases;Neurosciences

ORG_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

PI_NAMEs: BEZRUKOV, SERGEY M (contact)

PROJECT_TERMS: Aging;alpha helix;alpha Tubulin;Alzheimer's Disease;Amaze;amphiphilicity;Bacillus anthracis;Behavior;Benchmarking;beta barrel;Binding;Biological Assay;Biological Process;biophysical properties;biophysical techniques;Biophysics;C-terminal;Cell membrane;Cell Proliferation;Cells;Cellular biology;Characteristics;Clostridium botulinum;Clostridium perfringens;comparative;Complement;Complex;Confocal Microscopy;constriction;Data;Development;deviant;Diameter;Diffusion;Dimensions;dimer;Disease;electric field;Electrophysiology (science);Embryonic Development;Escherichia coli;Eukaryotic Cell;Exhibits;experimental study;flexibility;Fluorescence;Functional disorder;Genus Hippocampus;Geometry;Goals;Gram-Negative Bacteria;Gramicidin;gramicidin A;Hemolysin;hydrophilicity;Hydrophobicity;Imaging Techniques;Inclusion Bodies;interest;Ion Channel;Ions;Kinetics;Laboratories;Lateral;Learning;Length;Link;Lipid Bilayers;Lipids;live cell imaging;Location;long term memory;Malignant Neoplasms;Measurement;mechanical properties;Mechanics;Membrane;Membrane Lipids;membrane model;Membrane Potentials;Membrane Proteins;Memory;Metabolic;meter;Methods;Mitochondria;Modeling;Modification;Molecular;Molecular Conformation;Molecular Machines;Molecular Probes;monomer;Motivation;Muscle Cells;Mycobacterium smegmatis;Myocardial Infarction;Neurodegenerative Disorders;Neurons;novel;novel strategies;operation;OprF protein;Organism;Outer Mitochondrial Membrane;Parkinson Disease;Pathologic;Pathology;Permeability;pharmacologic;Play;predictive modeling;preservation;pressure;Probability;Process;Property;protein complex;Protein Denaturation;protein protein interaction;protein structure;Proteins;Pseudomonas aeruginosa;Radial;Recombinant Proteins;reconstitution;Regulation;response;Role;Side;single molecule;solute;Spectrum Analysis;Staphylococcus aureus;Stress;Stroke;Structure;sugar;Surface;synthetic peptide;Tail;Techniques;theories;Thinness;Time;Toxin;Tubulin;Tubulin Interaction;Two-Parameter Model;Variant;VDAC1 gene;Vestibule;voltage;voltage gated channel;Voltage-Dependent Anion Channel;Water

PROJECT_TITLE: Biophysics of Large Membrane Channels


NIH_SPENDING_CATS: Aging;Congenital Structural Anomalies;Lung;Orphan Drug;Osteogenesis Imperfecta;Pediatric;Rare Diseases

PI_NAMEs: LEIKIN, SERGEY  (contact)

PROJECT_TERMS: Affect;Aging;Amniotic Fluid;Anabolism;Animals;Arginine;Autophagocytosis;biological adaptation to stress;Birth;bone;bone fragility;bone scaffold;Breathing;Carpenter's Syndrome;Cell Culture Techniques;Cell Line;cell type;Cells;Cellular biology;Cellular Stress;Clinical;Clinical Research;Clustered Regularly Interspaced Short Palindromic Repeats;Coat Protein Complex I;Collaborations;Collagen;Collagen Type I;Complex;Connective Tissue;Connective Tissue Diseases;Cyclic AMP;Cyclic AMP-Dependent Protein Kinases;Deformity;Degenerative polyarthritis;Deposition;Development;Diagnostic;Disease;Ehlers-Danlos Syndrome;Endoplasmic Reticulum;endoplasmic reticulum stress;Enzymes;Epiphysial cartilage;Evaluation;Extracellular Matrix;Failure;fetal;Fibroblasts;Fibrosis;FLP recombinase;Fracture;gene editing technology;Glycine;Goals;Golgi Apparatus;Growth;Heat-Shock Proteins 70;Heterozygote;Human;Hydroxylation;Image;improved;in vivo;interest;Joint Laxity;Knock-out;Knowledge;life span;live cell imaging;Lung;lung failure;Lysosomes;Malignant Neoplasms;McCune-Albright Syndrome;Mitochondria;Modeling;Molecular;molecular pathology;mouse model;Movement;Mus;mutant;Mutation;new therapeutic target;novel;Osteoblasts;Osteogenesis Imperfecta;Osteoporosis;Pathogenicity;Pathology;Pathway interactions;Patients;Perinatal mortality demographics;Positioning Attribute;prevent;Procollagen;Procollagen-Proline Dioxygenase;Proline;Protein Subunits;Proteins;pulmonary hypoplasia;Pulmonary Pathology;Quality Control;recruit;Recycling;Research Personnel;Resources;response;rib bone structure;Role;secretory protein;sensor;Signal Transduction;Site;skeletal;skeletal abnormality;skeletal dysplasia;Skin;Stress;Structure;targeted treatment;Technology;Testing;therapeutic target;Tissues;trafficking;transcriptome sequencing;translational study;Translations;triple helix;United States National Institutes of Health;Uterine Fibroids;Uterus;vesicle transport

PROJECT_TITLE: Collagen-related diseases