ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Brain Disorders;Cerebral Palsy;Climate-Related Exposures and Conditions;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Intellectual and Developmental Disabilities (IDD);Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Social Determinants of Health

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Cerebral palsy (CP) is the most common life-long neuromotor condition that permanently affects children's physical The etiology of the majority of CP remains unknown, and research focusing on environmental risk factors has been sparse with no study on air pollution, despite being one of the most widespread environmental pollutants that can adversely affect preterm birth and fetal brain development. We propose to establish the largest population-based study of CP and air pollution using California birth records, and CP diagnosis records from the California Department of Developmental Services, and utilize a sophisticated land- use-regression model to investigate whether prenatal exposure to major ambient air pollutants poses a risk for CP development. mobility.

PI_NAMEs: LIEW, ZEYAN  (contact)

PROGRAM_OFFICER_NAME: GRAY, KIMBERLY A

PROJECT_TERMS: Address;adverse birth outcomes;Affect;Agriculture;Air;air monitoring;Air Pollutants;Air Pollution;ambient air pollution;Apgar Score;Area;Asphyxia;autism spectrum disorder;Automobile Driving;Biological Markers;Birth;Birth Records;Brain;Brain Injuries;California;Cerebral cortex;Cerebral Palsy;Characteristics;Chemicals;Child;Childhood;Childhood Asthma;Cities;Climate;Cognitive;cohort;comorbidity;Complex;Conceptions;Congenital Abnormality;cost;Data;Data Collection;Databases;design;Development;Developmental Disabilities;Diagnosis;Diagnostic;disability;Disease;Electronics;environmental disparity;Environmental Exposure;Environmental Pollutants;Environmental Risk Factor;Etiology;experience;Exposure to;fetal;fine particles;Government;Household;Individual;Industry;infancy;Knowledge;land use;Lesion;Literature;Locales;Malignant Neoplasms;Maternal Exposure;Mediating;Mediation;mobility aid;Modeling;Monitor;Motor;motor impairment;Movement;multidisciplinary;neurobehavioral;Neurologic;Newborn Infant;Nitrogen Dioxide;Nitrogen Oxides;novel;offspring;Outcome;Ozone;Particulate Matter;Patients;Pattern;Perinatal;Pesticides;Play;pollutant;Pollution;Population;Population Control;population health;Population Study;Pre-Eclampsia;Pregnancy;Pregnancy Complications;Premature Birth;prenatal;prenatal exposure;Primary Prevention;Problem behavior;Public Health;Race;Records;Reporting;Research;Resolution;Risk;Risk Factors;Role;Seasons;Self-Help Devices;Services;Siblings;social disparities;social vulnerability;Source;Surface;Thinness;Time;Transportation;United States;Update;volatile organic compound;warm temperature;Weather;white matter injury

PROJECT_TITLE: Air Pollution Exposure and Risk for Cerebral Palsy - A Statewide Study

STUDY_SECTION: RPPH

STUDY_SECTION_NAME: Reproductive, Perinatal and Pediatric Health Study Section[RPPH]


ADMINISTERING_IC: AG

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects

ORG_CITY: Aurora

ORG_COUNTRY: UNITED STATES

ORG_DEPT: OTOLARYNGOLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project narrative Nearly 2 out of 3 patients with Alzheimer’s disease (AD) experience problems with balance and mobility, which places them at increased risk of falling. The vestibular (inner ear balance) system plays an important role in balance stability, and vestibular therapy is well-known to improve balance function in healthy older adults. In this study, we will conduct a first-in-kind randomized clinical trial to evaluate whether vestibular therapy reduces fall rates in patients with AD, in whom this treatment has never been studied.

PI_NAMEs: AGRAWAL, YURI  (contact)

PROGRAM_OFFICER_NAME: ST  HILLAIRE-CLARKE, CORYSE

PROJECT_TERMS: active control;Adherence;Adult;Adverse event;Affect;Age;Alzheimer's Disease;Alzheimer's disease patient;Blinded;Brain;Calendar;Caregivers;clinical practice;Clinical Research;Clinical Trials;clinically significant;Cognition;Cognitive;cognitive skill;comorbidity;comparative efficacy;Compensation;Data;design;effective intervention;Effectiveness;Enrollment;equilibration disorder;Equilibrium;Event;Exercise;experience;fall risk;falls;follow-up;Fostering;Gait abnormality;Goals;Head;High Prevalence;Hospitalization;Impaired cognition;improved;Infrastructure;Injury;innovation;Institutionalization;Intervention;Labyrinth;Maps;Measures;Mediating;Memory;Morbidity - disease rate;mortality;Multicenter Trials;novel;Observational Study;older adult;Operative Surgical Procedures;Outcome;Participant;Patient Recruitments;Patients;Pharmaceutical Preparations;Phase;Physical therapy;Physiology;pilot trial;Play;Positioning Attribute;Prevalence;prospective;Public Health;Randomized;randomized, clinical trials;Randomized, Controlled Trials;recruit;Rehabilitation therapy;Research;Research Assistant;Resources;Risk;Risk Factors;Role;Rotation;Sampling;Sensory;System;Testing;treatment center;Vestibular dysfunction;Vestibular function;Vestibular loss;vestibular system;Work

PROJECT_TITLE: Clinical trial of vestibular therapy to reduce falls in patients with Alzheimer's disease


ADMINISTERING_IC: HD

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_CITY: RICHMOND

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: Project Narrative Children who are born preterm are at a high risk of development sensorimotor deficits, including developmental coordination disorder (DCD), one of the most common yet least studied developmental motor disorder. This study aims to investigate the predictive relationship between somatosensory processing deficits during early childhood in preterm children, and later motor development. Better understanding of the relationship between somatosensory deficits and motor development will allow us to identify children who experience these difficulties before they show significant motor delays and to develop tailored interventions for them.

PI_NAMEs: CHU, VIRGINIA WAY TONG (contact)

PROGRAM_OFFICER_NAME: NITKIN, RALPH M

PROJECT_TERMS: 1 year old;Activities of Daily Living;Adult;Apraxia;Cerebral Palsy;Child;Child Behavior;Childhood;Clinical;Development;Developmental Coordination Disorders;Diagnosis;early childhood;Early identification;Esthesia;experience;Feedback;Foundations;high risk;innovation;Intervention;Learning;Link;Measures;Methods;Motor;motor disorder;motor learning;Motor Skills;Movement;Nervous System;neuromuscular;Parents;pilot test;Play;programs;Proprioception;Reporting;Research;Role;Sensory;skill acquisition;somatosensory;System;Touch sensation

PROJECT_TITLE: Predictive ability of early somatosensory processing in preterm children on later motor development


ADMINISTERING_IC: AI

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: BRONX

ORG_DEPT: PATHOLOGY

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

ORG_STATE: NY

PHR: Project Narrative: Elderly individuals and mice have attenuated humoral responses accompanied by a rapid decline in antibody titers. Despite the crucial role of plasma cells in sustaining serological memory for extensive periods, they may contribute to humoral dysregulation in the aging immune system. This study introduces a novel competition model aimed at elucidating weakened antibody responses, providing insights to enhance humoral protection in this demographic.

PI_NAMEs: OVANDO, LUIS JOSE (contact)

PROGRAM_OFFICER_NAME: MOITRA, KAROBI

PROJECT_TERMS: Adult;Age;age related changes;Aging;aging population;Antibody Response;Antibody titer measurement;Attenuated;attenuation;B cell differentiation;Bone Marrow;candidate identification;candidate marker;Cell Physiology;Cell Survival;Cells;Clinical;Coupled;cytokine;Data;Elderly;Emerging Communicable Diseases;Enzyme-Linked Immunosorbent Assay;Exhibits;experimental study;Flow Cytometry;Generations;Genetic;Goals;healthspan;High-Throughput Nucleotide Sequencing;Human;Humoral Immunities;Immune system;Immune System Diseases;Impairment;improved;Individual;Infection;Inflammaging;Inflammatory;insight;intravital imaging;Lead;Libraries;Life;Longevity;Maps;Memory;Modeling;mortality;Motility;Mus;novel;old mice;Outcome;Outcome Study;Patients;Pattern;Plasma Cells;Play;Predisposition;pressure;prevent;radioresistant;Reporter;Research;Resistance;response;Risk Factors;Role;Serology;single-cell RNA sequencing;systemic inflammatory response;Testing;TNF gene;tool;Transgenic Mice;Transgenic Organisms;transmission process;two photon microscopy;two-photon;Vaccination;vaccine response;Vaccines;Work

PROJECT_TITLE: The Influence of Aging on Plasma Cell Function and Bone Marrow Competition

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F07B-G (20)]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Genetics;Human Genome;Mental Health;Mental Illness;Schizophrenia;Serious Mental Illness

ORG_CITY: DURHAM

ORG_DEPT: PEDIATRICS

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE: Despite its high heritability, the genetic foundations of schizophrenia (SCZ) remain largely unknown. While genome-wide association studies (GWAS) have identified loci linked to SCZ risk, our capacity to interpret and pinpoint causal variants and target genes lags behind our ability to identify disease- associated loci. Our lab employs CRISPR-Cas9 technologies to dissect candidate cis-regulatory elements in SCZ-associated loci and elucidate their target genes, promising insights into the genetic basis of SCZ.

PI_NAMEs: HAMILTON, MARISA C. (contact)

PROGRAM_OFFICER_NAME: VAN'T VEER, ASHLEE VICTORIA

PROJECT_TERMS: Affect;Area;ATAC-seq;base editing;Biological;Biology;causal variant;CCRL2 gene;Chromatin;Clustered Regularly Interspaced Short Palindromic Repeats;Code;Complex;Coupled;CRISPR interference;CRISPR screen;CRISPR/Cas technology;Data Analyses;deactivated CRISPR-Cas9;Delusions;Disease;disorder risk;Distant;Epigenetic Process;epigenome editing;exome sequencing;Flow Cytometry;Fluorescent in Situ Hybridization;Foundations;Gene Expression;Gene Expression Regulation;Gene Targeting;Genes;Genetic;Genetic Diseases;Genome;genome editing;genome wide association study;genomic locus;Genomics;Glutamates;Goals;Guide RNA;Hallucinations;Heritability;Hi-C;human genomics;Impaired cognition;In Vitro;induced pluripotent stem cell;insight;Knowledge;Link;Linkage Disequilibrium;Maps;Measures;Mental disorders;Methodology;Neurons;novel;obesity risk;Pathway interactions;Polygenic Traits;Positioning Attribute;psychiatric genomics;rare variant;Reaction;recruit;Regulatory Element;Role;Schizophrenia;schizophrenia risk;screening;single-cell RNA sequencing;social;Speech;Statistical Data Interpretation;Symptoms;Technology;Therapeutic Intervention;transcriptome sequencing;Untranslated RNA;Variant;Work

PROJECT_TITLE: Understanding gene regulation in schizophrenia-associated loci using high-throughput epigenetic CRISPR screens

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F08-L (20)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Dementia;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hematology;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases;Sickle Cell Disease;Social Determinants of Health;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: CINCINNATI

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CINCINNATI

ORG_STATE: OH

PHR: PROJECT NARRATIVE The aim of this project to determine the mechanism of racial disparity in the incidence and prevalence of severity of Alzheimer’s disease and Related Dementias (ADRDs), by examining whether the combined presence of sickle cell trait and other gene(s) associated with a higher risk of AD/ADRD will result in pathological changes in brain structure and microvessels, markers of neuroinflammation and abnormal brain lipid profile, and whether this underpins the earlier onset or more severe cognitive deficit.

PI_NAMEs: HYACINTH, HYACINTH IDU (contact)

PROGRAM_OFFICER_NAME: FRANKOWSKI, DAVID WITT

PROJECT_TERMS: Address;African American population;African ancestry;Age;Age Months;Alzheimer's disease related dementia;American;Amino Acid Substitution;Apolipoprotein E;Asian population;Behavioral;beta Globin;Biological;Biological Models;Blood Vessels;Bone Marrow;Bone Marrow Transplantation;Brain;brain abnormalities;Cerebral cortex;Cerebral small vessel disease;cerebrovascular;Chimera organism;Cognitive;Cognitive deficits;comparison control;conditioned fear;Data;Dementia;dementia risk;Development;Diagnosis;Direct Costs;Disparity;early onset;Engraftment;Epidemiology;ethnic difference;ethnic disparity;Ethnic Population;Facilities and Administrative Costs;Future;Genes;Genetic;genetic variant;Genetic Variation;Glutamic Acid;Hemoglobin;Heterozygote;High Prevalence;high risk;Hippocampus;Hispanic Americans;Hispanic Populations;Human;human old age (65+);Hypertension;Image;Immunohistochemistry;Impaired cognition;Incidence;Individual;Inherited;insight;Knock-in;Knock-in Mouse;Knowledge;lipidomics;Lipids;Molecular;morris water maze;mortality;mouse model;Mus;Mutation;neuroinflammation;Neurologic;Not Hispanic or Latino;novel;object recognition;Other Genetics;Outcome;Pacific Islander;Paper;Pathologic;Persons;pharmacologic;Point Mutation;Population;Positioning Attribute;Predisposition;Prevalence;Prospective Studies;Protein Isoforms;Publishing;racial difference;racial disparity;racial population;Randomized;Reporting;Risk;Risk Factors;risk variant;Role;Severities;Sickle Cell;Sickle Cell Anemia;Sickle Cell Trait;sickling;small molecule;social;Structure;Symptoms;Tamoxifen;Testing;Valine;vascular cognitive impairment and dementia;vascular risk factor;Work

PROJECT_TITLE: Interaction of sickle cell trait with human apolipoprotein E ε4: Impact on brain structure, brain lipidomics, neuroinflammation and cognitive deficit

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 AN-B (55)]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Hematology;Immunotherapy;Lymphatic Research;Lymphoma;Orphan Drug;Rare Diseases

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE . Diffuse large B-cell lymphoma (DLBCL) is the most common type of lymphoma with a very poor prognosis for patients who are diagnosed with relapsed or refractory (r/r) disease. Here we propose to test a promising treatment approach combining a clinical stage intravenously administered oncolytic Vesicular stomatitis virus (VSV) with a novel dually targeted checkpoint inhibitor (ONIx) in dogs with r/r DLBCL, to guide clinical development of this novel combination therapy for patients with r/r DLBCL. Detailed analyses to characterize the impact of combination therapy on the DLBCL tumor architecture and comparison of features of tumor microenvironment in responding versus nonresponding dogs will allow us to identify potential, clinically actionable biomarkers of response.

PI_NAMEs: MODIANO, JAIME F.;NAIK, SHRUTHI  (contact)

PROGRAM_OFFICER_NAME: SOMMERS, CONNIE L

PROJECT_TERMS: Agitation;anti-tumor immune response;Antigen Presentation;Architecture;biomarker identification;Canis familiaris;Chemotherapy-Oncologic Procedure;Clinic;Clinical;clinical development;clinically actionable;Combined Modality Therapy;companion animal;comparative;Correlative Study;Cytolysis;Diagnosis;Engineering;Genomics;Heterogeneity;Hodgkin Disease;Human;Immune;immune checkpoint blockade;Immune checkpoint inhibitor;immunogenic;Immunooncology;Immunosuppression;Immunotherapy;improved;insight;Institution;Intravenous;intravenous administration;large cell Diffuse non-Hodgkin's lymphoma;Lymphoma;Macrophage;Malignant Neoplasms;Mediating;Minnesota;Modeling;Mus;Mutation;neoplastic cell;Non-Hodgkin's Lymphoma;novel;Oncology;oncolytic Vesicular Stomatitis Virus;Oncolytic viruses;Pathology;patient prognosis;patient response;Patients;Phagocytosis;pre-clinical;Prognosis;prospective;Recurrent disease;Refractory;refractory cancer;Refractory Disease;Relapse;Resistance;Resources;response;response biomarker;Safety;Systemic Therapy;T cell response;T-Lymphocyte;Testing;Therapeutic;Toxic effect;Translations;tumor;Tumor Antigens;tumor microenvironment;Tumor-infiltrating immune cells;Universities;Vesicular stomatitis Indiana virus;Viral;virus development

PROJECT_TITLE: Translation of a novel combination therapy approach for non-Hodgkin lymphoma


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Cancer;Brain Disorders;Cancer;Nanotechnology;Neurosciences;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: DAVIS

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

ORG_STATE: CA

PHR: Project Narrative The proposed next generation blood-brain barrier-traversing and brain tumor penetrating nanoplatform addresses autophagy-dependent drug resistance and tumor recurrence and exhibits great potential to be translated into an effective treatment modality that could be easily integrated into the standard of care of high- grade gliomas. Due to the genetic and physiological similarities to humans, dogs with spontaneous high-grade gliomas are an ideal translational model that will accelerate the development of the proposed new therapeutic approaches. The team of experts in neuro-oncology (Dr. Bloch) and veterinary neurology (Dr. Toedebusch) will provide comprehensive expertise to facilitate the clinical development of the proposed novel nano-therapeutics that will ultimately benefit many human and canine patients with brain tumors.

PI_NAMEs: LI, YUANPEI  (contact)

PROGRAM_OFFICER_NAME: FU, YALI

PROJECT_TERMS: Acceleration;Address;Adverse effects;Aminoquinolines;Animal Model;Autophagocytosis;bevacizumab;Binding;Biodistribution;Biological Assay;Blood - brain barrier anatomy;blood-brain barrier crossing;blood-brain tumor barrier;Brain Neoplasms;Camptothecin-11;Cancer Patient;Canis familiaris;Cell Death;Cell model;Cell Survival;Cells;Central Nervous System;Central Nervous System Neoplasms;Chemoresistance;chemotherapy;Chloroquine;Clinical;clinical development;clinical translation;Clinical Treatment;Clinical Trials;Collaborations;companion animal;Comprehensive Cancer Center;Cyclic GMP;Dependence;Development;Dose;Drug Approval;Drug Delivery Systems;Drug Kinetics;Drug resistance;effective therapy;Exhibits;experience;first-in-human;Formulation;Genetic;Glioblastoma;Glioma;Goals;Heterogeneity;Human;Hydroxychloroquine;Immunocompetent;improved;inhibition of autophagy;inhibitor;Investigational Drugs;irinotecan;Lead;Link;liquid chromatography mass spectrometry;Magnetic Resonance Imaging;Malignant neoplasm of gastrointestinal tract;Malignant Neoplasms;Mediating;Modality;Modeling;Mus;nano;Nanodelivery;nanoformulation;nanoparticle;nanotechnology platform;nanotherapeutic;neuro-oncology;Neurology;next generation;novel;novel therapeutic intervention;optical imaging;patient derived xenograft model;Patients;Penetration;Pharmaceutical Preparations;pharmacophore;phase I trial;Phenotype;Physiological;pre-clinical;prevent;Primary Brain Neoplasms;Procedures;Production;Property;Quality Control;Radiation;Recurrence;Recurrent tumor;Research;Resistance;response;Rodent Model;Series;SN-38;spheroids;stability testing;standard care;standard of care;stem-like cell;stemness;temozolomide;Testing;Therapeutic;therapy resistant;Topoisomerase-I Inhibitor;Toxic effect;Toxicology;Translating;translation to humans;translational model;translational therapeutics;treatment response;tumor;tumorigenesis;United States;uptake;Veterinary Medicine;Veterinary Schools;Western Blotting

PROJECT_TITLE: Development of novel nanotherapeutics to overcome therapy resistance using canine brain tumor as a spontaneous model

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-U (55)]


ADMINISTERING_IC: CE

IC_NAME: NATIONAL CENTER FOR INJURY PREVENTION AND CONTROL

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Sweeping federal and state policy changes in 2020 brought on by the COVID-19 pandemic led to unprecedented access to telehealth care, allowing hundreds of thousands of people with opioid use disorder to connect to buprenorphine prescribers from their phone, tablet, or computer. However, research has not yet identified which telehealth policies worked best, and whether they worked equally well for people in rural areas, minorities, and low-income individuals. Thus, we will identify which combinations of telehealth policies were most effective at increasing buprenorphine receipt and reducing overdoses, while accounting for other changes in 2020, and then we will interview state authorities and experts to learn how to make these policy packages as effective as possible going forward.

PI_NAMEs: STRINGFELLOW, ERIN  (contact)

PROJECT_TITLE: CE24-012 - Evaluating Telehealth's Role in Buprenorphine Treatment Initiation and Retention, Overdose Mortality, and Access Equity: An Analysis for Policy Development

STUDY_SECTION_NAME: Special Emphasis Panel[ZCE1 AW (12)]


PHR: PROJECT NARRATIVE. In rare but deadly instances, lung cancer can spread to the cerebrospinal fluid, and this form of metastatic disease is difficult to diagnose and treat. My research focuses on advancing our understanding of how exactly cells enter and survive in the cerebrospinal fluid and the mechanisms by which developing resistance to targeted treatments can increase the likelihood of cells making this journey. The results of this research will hopefully lead to identification of novel treatment targets for this currently incurable disease.

PI_NAMEs: KANDIGIAN, SAVANNAH ELIZABETH (contact)

PROGRAM_OFFICER_NAME: ODEH, HANA M

PROJECT_TERMS: Address;Anatomy;Anoikis;Astrocytes;autocrine;Bar Codes;Basement membrane;Binding;biobank;Biological Assay;blood cerebrospinal fluid barrier;Blood Vessels;Brain;brain tissue;cancer cell;Cancer Patient;cancer survival;cancer type;Cell Death Induction;Cell Survival;Cells;Central Nervous System;Central Nervous System Diseases;Cerebrospinal Fluid;Circulation;Clinical;clinically relevant;comorbidity;Complication;Development;Diagnosis;Disease;disease model;Disease Pathway;Disease Progression;Drug resistance;Epidermal Growth Factor Receptor;experimental study;Fellowship;Fostering;Functional disorder;gain of function;Generations;Goals;graduate student;In Vitro;in vivo;in vivo Model;Infiltration;insight;Integrins;Interstitial Collagenase;Intra-Arterial Injections;Invaded;knock-down;Laboratories;Laminin;Lead;Leptomeninges;Lesion;Link;loss of function;lung cancer cell;Malignant neoplasm of lung;Maps;mechanotransduction;Mediating;Mentors;Metalloproteases;Metastatic Neoplasm to the Central Nervous System;Metastatic Neoplasm to the Leptomeninges;migration;Modeling;Molecular;mortality;mouse model;Mus;mutant;National Research Service Awards;Neoplasm Circulating Cells;Neoplasm Metastasis;neoplastic cell;neutralizing antibody;Non-Small-Cell Lung Carcinoma;novel;paracrine;Pathology;Pathway interactions;Patients;Pattern;Penetrance;Phenotype;Physiology;Play;prevent;Process;Prognosis;Prognostic Marker;Proteins;Receptor Cell;Recombinants;Research;Research Personnel;Resistance;Resistance development;Resolution;Role;Route;Sampling;Signal Transduction;skills;small hairpin RNA;Source;spatiotemporal;standard of care;stem;Structure of choroid plexus;Subarachnoid Space;TIMP1 gene;Tissue Inhibitor of Metalloproteinase-1;transcriptomics;tumor;Tumor Cell Migration;tumor microenvironment;tumor progression;Tumor Promotion;Tyrosine Kinase Inhibitor;Universities

PROJECT_TITLE: Elucidating mechanisms underlying NSCLC progression to leptomeningeal disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F09B-C (20)]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: TAMPA

ORG_NAME: UNIVERSITY OF SOUTH FLORIDA

ORG_STATE: FL

PHR: Project Narrative  The proposed diversity extension will develop zebrafish model for human venous malformation (VM), which shows enlarged vascular lumen, and will test the role of SH2 domain protein E (SHE) and Abelson (ABL) kinase signaling in the zebrafish VM model. The acquired knowledge will promote development of new strategies aimed at treating vascular malformations as well as bioengineering new vessels for regenerative therapies. The diversity extension will also enable a training of a candidate with underrepresented minority background, thus helping to foster diversity in science.

PI_NAMEs: SUMANAS, SAULIUS  (contact)

PROGRAM_OFFICER_NAME: GAO, YUNLING

PROJECT_TERMS: Address;Animal Model;Animals;Applications Grants;Appointment;Award;Biomedical Engineering;Blood Vessels;Cell Culture Techniques;Cells;Clinical;Complex;Creativeness;Development;Diameter;E protein;Endothelial Cells;Ethics;Event;experimental study;fluid flow;Fostering;Generations;Human;Human Pathology;improved;Individual;inducible gene expression;Knowledge acquisition;Life Experience;malformation;Manuscripts;Mentors;Modeling;Molecular;Mus;mutant;Mutate;Mutation;Natural regeneration;novel therapeutic intervention;overexpression;Parents;Pathogenesis;Pathway interactions;Patients;Phosphotransferases;prevent;protein E;Proteins;regenerative therapy;repaired;Research;Research Proposals;Role;Science;Scientist;Signal Transduction;src Homology Region 2 Domain;symposium;TEK gene;Testing;Therapeutic;TIE-2 Receptor;Training;Training Activity;Transgenic Organisms;Tube;Umbilical vein;Underrepresented Minority;vascular bed;Vascular Diseases;Venous Malformation;Writing;Xenograft procedure;Zebrafish

PROJECT_TITLE: Role of SHE and ABL signaling in vascular tubulogenesis


ORG_CITY: Oakland

ORG_NAME: KAISER FOUNDATION RESEARCH INSTITUTE

PHR: PROJECT NARRATIVE – P01, Clinical Care Gaps and Unmet Needs in AYA Cancer Survivors  This program of research is focused on the cancer care experience of adolescents and young adults (AYAs) who are diagnosed with cancer during the ages of 15 to 39 years. It involves three research projects, focusing on different aspects of care relevant to AYAs: preservation of fertility and impact on cancer care, coordination of care among multiple providers including during the transition from active cancer treatment to surveillance and follow-up, and late effects that AYA cancer survivors may experience. These projects are supported by three cores that provide biostatistical, survey, and administrative support to program activities.

PI_NAMEs: KEEGAN, THERESA H M;KUSHI, LAWRENCE H (contact)

PROGRAM_OFFICER_NAME: SMITH, ASHLEY

PROJECT_TERMS: Accident and Emergency department;Acute;Address;Adolescent;Adolescent and Young Adult;Adolescent and young adult cancer patients;Adult;Advocate;Aftercare;Age;aged;Ambulatory Surgical Procedures;Area;barrier to care;Biometry;Breast;California;cancer care;cancer diagnosis;Cancer Patient;Cancer Survivor;cancer therapy;cancer type;Cardiovascular Diseases;care coordination;care preference;career;Caring;Child;child bearing;Childhood;Chronic;clinical care;Colorectal;Continuity of Patient Care;Counseling;Data;data harmonization;data resource;Diagnosis;Disparity;Emergency department visit;Employment;Endocrine System Diseases;Epidemiologist;Ethnic Origin;evidence base;experience;Face;Family;Fertility;fertility preservation;Financial Hardship;follow-up;Goals;Guidelines;Health;health care service utilization;health care settings;Health Insurance;Health Resources;Health Services;Health system;Healthcare;higher education;Home;Hospitalization;improved;improved outcome;Incidence;Individual;Inpatients;Insurance;Insurance Coverage;Interdisciplinary Study;interest;Kidney Diseases;Knowledge;Late Effects;Life;Link;Liver diseases;Lymphoma;Malignant neoplasm of testis;Malignant Neoplasms;Medical;multidisciplinary;National Cancer Institute;National Comprehensive Cancer Network;neglect;Neighborhoods;neoplasm registry;North Carolina;older adult;Older Population;Oncologist;Outcome;Outpatients;Patient Preferences;Patient-Centered Care;Patients;Persons;Phase;Population;Population Database;population health;Population Surveillance;preservation;Preservation Technique;programs;Provider;Puberty;Race;Recommendation;Reporting;Reproductive Health Services;Research;Research Personnel;Research Project Grants;Resource Sharing;Respiratory Disease;Risk;Second Primary Cancers;Services;Socioeconomic Status;Specialist;Surveys;survivorship;United States;Universities;University resources;Utah;Visit

PROJECT_TITLE: Clinical Care Gaps and Unmet Needs in Adolescent and Young Adult (AYA) Cancers


NIH_SPENDING_CATS: Biotechnology;Cancer;Childhood Leukemia;Genetics;Hematology;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: PROJECT NARRATIVE Target-directed microRNA degradation (TDMD) is a mechanism by which endogenous target RNAs degrade specific microRNAs to modulate gene expression. Treatment of T-cell acute lymphoblastic leukemia (T-ALL) cells by glucocorticoid induces apoptosis through BIM expression, which can lead to microRNA-221/222 degradation via TDMD. We will examine how microRNA-221/222 degradation may contribute to T-ALL apoptosis, globally profile TDMD events and explore the role of TDMD during glucocorticoid-treatment of T-ALL.

PI_NAMEs: LICHT, JONATHAN D.;XIE, MINGYI  (contact)

PROGRAM_OFFICER_NAME: JHAPPAN, CHAMELLI

PROJECT_TERMS: Acute Lymphocytic Leukemia;Acute T Cell Leukemia;acute T-cell lymphoblastic leukemia cell;Affect;Apoptosis;Apoptotic;Bar Codes;Base Pairing;Binding;Biochemical;bioinformatics pipeline;cancer cell;Cancer Intervention;cancer therapy;career development;Cell Death;Cell Membrane Permeability;Cells;chemotherapy;Clustered Regularly Interspaced Short Palindromic Repeats;Code;combat;CRISPR/Cas technology;Data Set;Degradation Pathway;Development;Development Plans;Dexamethasone;differential expression;DNA;Elements;Enzymes;Event;Gene Expression;Gene Expression Regulation;gene regulatory network;Genes;genetic information;Genetic Transcription;Glucocorticoid-induced apoptosis;Glucocorticoids;improved;Induction of Apoptosis;innovation;insight;leukemia;Leukemia Acute Lymphoblastic Chemotherapy;Malignant Childhood Neoplasm;Malignant Neoplasms;Measures;Mediating;Mentors;Messenger RNA;Methods;MicroRNAs;mitochondrial membrane;Molecular;mouse model;Mutant Strains Mice;Mutate;Mutation;Mutation Analysis;Names;novel;novel therapeutics;Nucleotides;Oncogene Activation;Oncogenic;parent grant;Pathway interactions;patient derived xenograft model;Patients;Pattern;prevent;pro-apoptotic protein;Process;Proteins;Protocols documentation;Regulation;Repression;Research;Resistance;resistance mechanism;RNA;Role;Sampling;Small RNA;standard care;Steroids;Tail;Therapeutic Intervention;Transcript;transcriptome;transcriptome sequencing;Translating;Tumor Suppressor Proteins;ubiquitin ligase;Untranslated Regions;Untranslated RNA;Validation

PROJECT_TITLE: Exploring microRNA degradation in T-cell acute lymphoblastic leukemia


ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

PHR: Project NarraƟve The SABIR database contains average glandular dose (? ? ) values, the metric of interest in breast dosimetry, extracted directly from the DICOM header of that exam. The models employed by the vendors to esƟmate ? ?  are out of date and mistakenly assume that the breast is composed of a homogenous mixture of 50% glandular and 50% adipose Ɵssue (hereaŌer referred to as “? ? ,ℎ? ? ? ”). We therefore propose to establish new ? ?  values for the SABIR database using the now universally accepted, realisƟc heterogenous breast model “? ? ,ℎ? ? ? ? ? ” and explore characterisƟcs of ? ? ,ℎ? ? ? ? ?  in DM and DBT across breast density, compressed thickness, and paƟent BMI.

PI_NAMEs: KERLIKOWSKE, KARLA M;MIGLIORETTI, DIANA L (contact);TOSTESON, ANNA N. A.

PROGRAM_OFFICER_NAME: CROSWELL, JENNIFER

PROJECT_TERMS: 3-Dimensional;Adipose tissue;Anatomy;Area;Benchmarking;Body mass index;Breast;Breast Cancer Detection;Breast Cancer Risk Factor;breast density;breast imaging;cancer risk;Databases;Diagnosis;Digital Breast Tomosynthesis;Digital Imaging and Communications in Medicine;Digital Mammography;Dose;dosimetry;Image;insight;interest;ionization;Joints;Metadata;Modeling;Performance;Publishing;Registries;risk prediction;Thick;Vendor;X-Ray Medical Imaging

PROJECT_TITLE: Refining and expanding breast dosimetry for the Sacramento Area Breast Imaging Registry


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Brain Cancer;Brain Disorders;Cancer;Mental Health;Neurosciences;Pediatric;Pediatric Cancer;Radiation Oncology;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

PHR: Project Narrative: The proposed supplement will provide support and resources to a graduate student to investigate the extent to which developmental changes in cell death regulation drive radiation therapy-induced neurotoxicity, as well as how sensitivity to toxic effects may differ by neural cell type. This proposal aligns well with the objectives of the original R37 award and has the potential to uncover novel mechanisms linking cellular differentiation with apoptosis suppression. The training will help the candidate develop the necessary skills to advance their career in molecular biology research, with a focus on cancer biology, radiation biology and neurotoxicology.

PI_NAMEs: SAROSIEK, KRISTOPHER ANDREW (contact)

PROGRAM_OFFICER_NAME: PRASANNA, PAT G

PROJECT_TERMS: Adult;Age;age related;Animals;ANXA5 gene;Apoptosis;Apoptotic;Astrocytes;Automobile Driving;Award;BAX gene;Bax protein;BCL1 Oncogene;BCL2L1 gene;BIM Bcl-2-binding protein;Biological Assay;Brain;brain tissue;Cancer Biology;Cancer Etiology;Cancer Survivor;Cancerous;career;CASP3 gene;Cell Death;Cell Differentiation process;Cell Line;cell type;Cells;Cellular Stress;Cessation of life;Child;Childhood;Cognitive deficits;cognitive development;Collecting Cell;Communication;Development;Developmental Process;differentiation in vitro;Dissociation;Dose;experience;External Beam Radiation Therapy;Functional disorder;Genes;Genetic Transcription;Goals;graduate student;Hour;Human;Impaired cognition;improved;In Vitro;Induction of Apoptosis;Ionizing radiation;knock-down;Knowledge;Link;Malignant Childhood Neoplasm;Malignant neoplasm of central nervous system;Measures;Medulloblastoma;Modeling;Molecular;Molecular Biology;Molecular Biology Techniques;Morbidity - disease rate;Mus;nerve stem cell;neural circuit;Neurocognitive Deficit;neurodevelopment;Neuronal Differentiation;Neurons;neuroprotection;Neuroprotective Agents;neurotoxicity;neurotoxicology;new therapeutic target;novel;Oligodendroglia;Operative Surgical Procedures;parent grant;Pathway interactions;pediatric patients;Play;Predisposition;pro-apoptotic protein;Protein Dephosphorylation;protein expression;Protein Family;Proteins;Quality of life;Radiation Dose Unit;Radiation exposure;Radiation therapy;Radiation-Induced Change;Radiobiology;Regulation;Research;Resistance;Resources;response;Role;Signal Transduction;skills;Small Interfering RNA;Students;Testing;Time;Toxic effect;Toxicology;Training;Undifferentiated;Western Blotting;Work

PROJECT_TITLE: Developmental regulation of apoptosis as a modifiable driver of radiotherapy-induced neurocognitive impairment in pediatric patients

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Dietary Supplements;Hematology;Maternal Health;Maternal Morbidity and Mortality;Nutrition;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Women's Health Research

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Summary Sumadhur is a group intervention for multiple households of newly married women, their husbands and mothers-in-law aimed to improve women’s status and norms, household relationships, and behaviors and knowledge around nutrition and eating, developed and piloted in rural Nepal. This proposal aims to test the effectiveness of Sumadhur on young newly married, preconception women’s anemia and micronutrient status, combined with access to micronutrient supplements, and measure pathways of change.

PI_NAMEs: DIAMOND-SMITH, NADIA GRIFFI (contact)

PROGRAM_OFFICER_NAME: CHAKHTOURA, NAHIDA ABDO

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;Anemia;antenatal care;arm;Asia;Behavior;behavior change;Behavioral;Blood;care seeking;Child;Child Health;Collaborations;Communication;Communities;community partners;Conceptions;Consumption;cost;Costs and Benefits;Couples;Data;Data Collection;design;dietary;disability-adjusted life years;Eating;Education;Effectiveness;effectiveness outcome;effectiveness testing;empowerment;Ensure;experience;First Births;First Pregnancy Trimester;Folic Acid;folic acid supplementation;Food;food insecurity;Gender;group intervention;Health;Health behavior and outcomes;health knowledge;Healthcare;Hemoglobin;Household;Husband;implementation study;improved;Individual;Inequality;Inequity;Infant Health;infant outcome;intergenerational;Intervention;intervention participants;Interview;Iron;Knowledge;Laws;Lead;Low Birth Weight Infant;Marriage;Maternal Health;Maternal Health Services;maternal morbidity;Maternal Mortality;maternal outcome;Measures;Mediation;member;micronutrient deficiency;Micronutrients;Morbidity - disease rate;mortality;mother nutrition;Mothers;neonatal health;Nepal;Newborn Infant;novel strategies;nutrition;Nutritional;Nutritional status;Outcome;Participant;Pathway interactions;Pattern;Perinatal mortality demographics;Persons;Phase;Pilot Projects;pilot test;Policies;Population;post intervention;Pregnancy;pregnancy health;pregnant;Pregnant Women;Premature Birth;Prenatal Nutrition;Prevalence;primary health center;primary outcome;programs;Randomized;Randomized, Controlled Trials;Recommendation;Reproductive Health;Research;Rural;scale up;secondary outcome;social;Supplementation;Surveys;Testing;Time;uptake;Vitamin B 12;Woman;Women Status;Women's Health;Work;Zinc

PROJECT_TITLE: Reducing anemia among young, preconception women in Nepal through a household level group norm and behavior change intervention and micronutrient supplementation

STUDY_SECTION: CMGC

STUDY_SECTION_NAME: Clinical Management in General Care Settings Study Section[CMGC]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Data Science;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences;Precision Medicine;Prevention

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE It remains largely unclear which genetic factors underlie well-established sex differences in Alzheimer’s disease (AD). This proposal will fill in this gap by using a series of state-of-the-art innovative approaches to discover sex- specific genetic risk variants for AD, including performing the largest sex-stratified genome-wide association study of AD to date, studying for the first time the role of X-chromosome and sex-specific rare variant effects on AD, and using rich proteomics data to discover new AD risk genes. Findings from this work will help gain important insights into the pathophysiology of AD, identify novel sex-specific risk factors relevant to personalized genetic medicine, and uncover potential new AD drug targets that may more optimally benefit both sexes.

PI_NAMEs: BELLOY, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: BENNANI-BAITI, MICHAEL

PROJECT_TERMS: Affect;Age;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease risk;Amyloid;apolipoprotein E-4;autosome;Big Data;Biology;Brain;brain tissue;candidate validation;career;Cerebrospinal Fluid;Clinical;Cognitive;cohort;Coupled;Data;data harmonization;data integration;Data Set;Dementia;differential expression;Disease;Disease Progression;Drug Targeting;endophenotype;Energy Metabolism;exome;Fellowship;Functional disorder;gene discovery;Genes;Genetic;genetic association;Genetic Diseases;Genetic Medicine;Genetic Risk;genetic risk factor;Genetic study;Genetic Transcription;genetic variant;Genome;genome wide association study;genome-wide;genotypic sex;Goals;hazard;high risk;Image;improved;innovation;insight;large datasets;Late Onset Alzheimer Disease;Learning;Link;Maps;men;Mentors;Methods;Modeling;Molecular;Molecular Disease;Multiomic Data;multiple omics;Mus;Neurology;new therapeutic target;novel;Outcome;Parkinson Disease;Pathogenesis;Pathology;Pathway interactions;Persons;Phase;Phenotype;Postdoctoral Fellow;precision genetics;programs;Proteins;proteomic signature;Proteomics;rare variant;Research;Resources;Risk Factors;risk variant;Role;Sample Size;Sampling;Scientist;Series;sex;Sex Bias;Sex Differences;sexual dimorphism;skills;Source;Statistical Models;success;tau Proteins;Thick;Time;Training;Transcript;United States;Validation;Variant;Woman;Work;X Chromosome

PROJECT_TITLE: Elucidating sex-specific risk for Alzheimer's disease through state-of-the-art genetics and multi-omics

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ORG_CITY: HOUSTON

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: Project Narrative Atrial fibrillation, the most prevalence arrhythmia, is a public health burden. The proposed work will elucidate the function of interleukin-1b and gasdermin-D, two key players of inflammasome signaling in cardiomyocytes and how the gasdermin-D/interleukin-1b nexus in cardiomyocytes promotes the pathogenesis of atrial fibrillation.

PI_NAMEs: LI, NA  (contact)

PROGRAM_OFFICER_NAME: SHI, YANG

PROJECT_TERMS: Ablation;Acute;adeno-associated viral vector;anakinra;Antibodies;Arrhythmia;Atrial Fibrillation;Attenuated;Biological Process;Cardiac Myocytes;CASP1 gene;Cell Death;Cell membrane;Cells;Chronic;cytokine;Data;Development;Event;Exhibits;Frequencies;gain of function;Goals;Heart Atrium;Human;Immune;In Vitro;Inflammasome;Inflammatory;Interleukin-1;Interleukin-1 Receptors;Interleukins;knock-down;Lytic;Mediating;Modeling;Molecular;mouse model;Mus;Mutate;N-terminal;neutralizing antibody;novel;Obesity;outcome prediction;Outcome Study;overexpression;Pathogenesis;Patients;Phenotype;Pilot Projects;Play;Postoperative Period;Predisposition;Prevalence;prevent;Proteins;Public Health;receptor;Refractory;Research Project Grants;Role;Signal Transduction;System;Testing;Work

PROJECT_TITLE: The Role of Gasdermin-D/Interleukin-1 Nexus in Atrial Arrhythmogenesis

STUDY_SECTION: MPPB

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology B Study Section[MPPB]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;Infectious Diseases;Rare Diseases;Vector-Borne Diseases;West Nile Virus

ORG_CITY: NEW YORK

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: PROJECT NARRATIVE: CCR5 is a chemokine receptor that has a critical role in neuroprotection against a wide range of neurotropic flaviviruses in mice and humans. In this application, we will generate essential tools to investigate the critical role of Ccr5 in mice that will allow us to dissect the precise role of Ccr5 during infection and inflammation. Our proposal seeks to generate tools that will propel our understanding of Ccr5 biology both at homeostasis and during inflammation.

PI_NAMEs: LIM, JEAN KYOU (contact)

PROGRAM_OFFICER_NAME: JOFFE, AARON MICHAEL

PROJECT_TERMS: Amino Acids;antagonist;Antibodies;Antigens;beta Actin;Binding;Biological Assay;Biology;Blood Cells;CCR5 gene;Cells;Cerebral Malaria;chemokine;chemokine receptor;Chronic Disease;Clinical Trials;cohort;Collection;combinatorial;Communities;Compensation;Data;Disease;Enterobacteria phage P1 Cre recombinase;Epitopes;European;European ancestry;Evaluation;Excision;Exposure to;extracellular;Extracellular Domain;FDA approved;Flavivirus;Flow Cytometry;Frequencies;G-Protein-Coupled Receptors;Generations;Genetic;Genetic Transcription;Hematopoietic;HIV;HIV Infections;HIV Receptors;HIV-1;Homeostasis;Homozygote;Host Defense;Human;human subject;Hybridomas;Immunity;Immunize;Immunofluorescence Immunologic;Individual;Infection;Inflammation;Inflammatory;Initiator Codon;innovation;insight;interest;Investigation;Japanese encephalitis virus;Length;Leukocyte Trafficking;lipid nanoparticle;LoxP-flanked allele;Mediating;Membrane;Messenger RNA;Monoclonal Antibodies;mouse model;Mus;N-terminal;neuroprotection;neurotropic;novel;pathogen;Pathway interactions;Pattern;Peptides;Predisposition;programs;Proteins;Public Health;Reagent;receptor;Reporter;Research;Research Personnel;Resources;RNA;Role;Site;Specificity;System;Terminator Codon;Testing;Tick-Borne Encephalitis;Tick-Borne Encephalitis Virus;Tissues;tool;Toxoplasma gondii;Translating;West Nile viral infection;West Nile virus;Western Blotting;Wild Type Mouse;Zika Virus

PROJECT_TITLE: Developing Novel Tools to Study Chemokine Receptor Ccr5 Expression and Function in Mice

STUDY_SECTION: CMIA

STUDY_SECTION_NAME: Cellular and Molecular Immunology - A Study Section[CMIA]


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Childhood Leukemia;Genetics;Hematology;Human Genome;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: Project Narrative This project is relevant to public health because it addresses a novel mechanism by which interactions of aggressive cancers such as acute myeloid leukemia (AML) with their niche can promote disease progression. If successful, this work will provide a scientific basis for development of new strategies to treat these aggressive cancers with less than 25% survival rates. This is highly relevant to the NIH mission of developing fundamental knowledge to help reduce the burdens of human disability.

PI_NAMEs: BAJAJ, JEEVISHA  (contact)

PROGRAM_OFFICER_NAME: KLAUZINSKA, MALGORZATA

PROJECT_TERMS: Activities of Daily Living;Acute Myelocytic Leukemia;acute myeloid leukemia cell;Address;Adhesives;adult stem cell;Blast Phase;Bone Marrow;cancer cell;Cell Death;Cell Line;Cell surface;Cells;Chronic Myeloid Leukemia;comparison control;CRISPR screen;Data;Data Set;Development;disability;Disease;disease model;Disease Progression;Endothelial Cells;Environment;Enzymes;Genes;Genetic;genome-wide;Goals;Growth;Growth Factor;Hematopoiesis;Hematopoietic stem cells;Human;Impairment;In Vitro;in vivo;interest;knock-down;Knowledge;leukemia;Leukemic Cell;leukemic stem cell;leukemogenesis;Malignant Neoplasms;Mediating;Mission;MLL-AF9;mouse model;Mus;Mutation;Myelogenous;Myeloid Leukemia;myeloid leukemia cell;Myeloproliferative disease;new therapeutic target;Non-Essential Amino Acid;novel;Oncogenes;Osteoblasts;osteogenic;osteoprogenitor cell;Patients;Pilot Projects;Prognosis;Proliferating;Public Health;Receptor Signaling;reconstitution;Resistance;Role;self-renewal;Signal Transduction;single-cell RNA sequencing;small hairpin RNA;stem cell self renewal;stem cells;Stromal Cells;Surface Antigens;Survival Rate;Taurine;taurine transporter;Testing;The Cancer Genome Atlas;therapy resistant;transcriptome sequencing;United States National Institutes of Health;Work;Xenograft Model

PROJECT_TITLE: Targeting Microenvironmental Signals in Myeloid Malignancies


ORG_NAME: YALE UNIVERSITY

PHR: Refer to Parent Grant

PI_NAMEs: HURWITZ, MICHAEL E;KATZ, SAMUEL G (contact)

PROGRAM_OFFICER_NAME: HU, ZHANG-ZHI

PROJECT_TERMS: Acclimatization;Adhesions;angiogenesis;antigen binding;Antigen-Presenting Cells;Antitumor Response;Apoptotic;autocrine;Autologous Tumor Cell;Binding;cancer cell;Canis familiaris;CCR;Cell Differentiation process;cell mediated immune response;cell motility;Cell Proliferation;Cell Reprogramming;Cells;chimeric antigen receptor;chimeric antigen receptor T cells;Clinical;Clinical Trials;Coupled;cytokine;cytotoxicity;Data;Dose;effector T cell;efficacy evaluation;ERBB2 gene;Event;Exhibits;experimental study;Extracellular Matrix Degradation;FRAP1 gene;Frequencies;gene therapy;Generations;Genes;Genetic Transcription;Goals;Growth;Heterogeneity;HGF gene;Hypoxia;Immunologic Factors;Immunotherapy;improved;In Vitro;in vivo;Infrastructure;Infusion procedures;inhibitor;Interleukin-2;Invaded;Knowledge;Lesion;life span;Ligands;Lymphocyte Activation;lymphocyte product;Malignant - descriptor;Malignant Neoplasms;MAP Kinase Gene;Mediating;melanocyte;Melanoma;Melanoma Cell;Melanoma patient;Melanoma Tumor;Memory;Messenger RNA;Methods;migration;Modeling;Motility;mRNA Expression;multidisciplinary;Mus;Mutation;Neoplasm Metastasis;neoplastic cell;novel;Outcome;overexpression;OX40;parent grant;Pathway interactions;patient derived xenograft model;patient population;Patients;Phenotype;Phosphotransferases;PIK3CG gene;Population;Positive Reinforcements;pre-clinical;prevent;Probability;Process;Production;programs;Proliferating;Proteins;Receptor Protein-Tyrosine Kinases;Regulation;Research Project Summaries;response;Safety;Signal Pathway;Signal Transduction;single cell analysis;Solid Neoplasm;Supporting Cell;System;T-Cell Receptor;T-Lymphocyte;targeted treatment;therapeutic development;Time;TNFSF4 gene;Transgenic Mice;Treatment Efficacy;tumor;Tumor Antigens;Tumor Expansion;tumor growth;tumor infiltrating lymphocyte therapy;tumor microenvironment;Tumor-Infiltrating Lymphocytes;tumorigenesis;Up-Regulation;Work

PROJECT_TITLE: Enhancing Melanoma TIL Efficacy with Multifactor mRNA-Mediated T Cell Reprogramming


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: Project Narrative I have identified the number of B cell antigen receptor binding sites (BCRbs) as a new parameter that is actively organized at the surface of B lymphocytes to optimize antigen recognition, seeding the production of antibody responses and the development of humoral immunity. Key to this work has been my innovation of a molecular tool to experimentally count the absolute number of BCRbs on the B cell surface. In this proposal, I will apply my tool to define how BCRbs number is enhanced to promote antigen reception during B cell development and how this parameter also serves to organize the antibody affinity-driven selection that follows immune challenge.

PI_NAMEs: ROSADO, VICTORIA CELINE (contact)

PROGRAM_OFFICER_NAME: MOITRA, KAROBI

PROJECT_TERMS: Affinity;Antibodies;Antibody Affinity;Antibody Formation;Antibody Response;antigen binding;Antigens;Avidity;B-Cell Antigen Receptor;B-Cell Development;B-Cell Receptor Binding;B-Lymphocyte Subsets;B-Lymphocytes;Binding;Binding Sites;Biotinylation;Blood;Bone Marrow;Buffers;Cell membrane;Cell surface;Cells;Complex;Data;Development;Flow Cytometry;Frequencies;Genetic Transcription;Homo sapiens;Human;Humoral Immunities;Immune;Immune response;Immunoglobulin D;Immunoglobulin G;Immunoglobulin M;Immunoglobulins;Individual;Infection;Influenza;Influenza Hemagglutinin;influenza infection;innovation;Label;Ligands;Light;Link;Local Anti-Infective Agents;longitudinal analysis;Lung;lymph nodes;lymphoid organ;Mature B-Lymphocyte;Measures;Mediastinal lymph node group;Membrane;Messenger RNA;Modeling;Molecular;molecular scale;monomer;mouse model;Mus;nanobodies;Output;pathogen;Reaction;Reagent;receptor binding;Recombinants;recruit;Regulation;RNA Splicing;secondary lymphoid organ;single molecule;Site;Spleen;Streptavidin;Structure;Structure of germinal center of lymph node;Surface;Surface Antigens;Surveys;T-Lymphocyte;Testing;Time;tool;Variant;Viral Antigens;virtual;Work

PROJECT_TITLE: Regulation of B cell receptor avidity to organize antigen recognition


ADMINISTERING_IC: EB

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Nanotechnology;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Nonembryonic - Human

ORG_CITY: GOLDEN

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: COLORADO SCHOOL OF MINES

PHR: PROJECT NARRATIVE This supplemental award will support the research training of Ms. Caitlyn Castellion, a freshman intending to major in Biochemistry at the Colorado School of Mines. Women, particularly Hispanic women such as Ms. Cas- tellion are severely under-represented at Mines, where student demographics skew white male. Over a period of 18 months, Ms. Castellion will be trained in polymer brush synthesis, lithographic techniques needed for na- nopatterning, hMSC Culture and characterization, and polymer-mediated gene delivery, allowing her to acquire meaningful and authentic research experiences in preparation for her PhD and post-graduate training.

PI_NAMEs: KUMAR, RAMYA  (contact)

PROGRAM_OFFICER_NAME: RUSSELL, LUISA MARIE

PROJECT_TERMS: Award;Biochemistry;Budgets;career;career development;Cell Culture Techniques;Cells;Cellular Assay;Colorado;Data;demographics;Dependence;Development Plans;Doctor of Philosophy;Exhibits;experience;Faculty;forging;Foundations;GAG Gene;Gene Delivery;Gene Modified;Glycocalyx;Goals;Group Meetings;Hispanic Women;Institution;interest;Life Experience;Ligands;lithography;male;Mammalian Cell;Mediating;meetings;member;Mentors;Mesenchymal Stem Cells;mimetics;Molecular Biology;nanocluster;nanopattern;Oral;polycation;Polymers;Polysaccharides;Postdoctoral Fellow;Preparation;Proliferating;Proteomics;Publications;receptor;Research;Research Support;Research Training;Role;Schools;Scientist;self-renewal;skills;Solid;Spatial Distribution;Students;sugar;Sulfate;Surface;Synthesis Chemistry;Technical Expertise;Techniques;tenure track;Testing;Thick;Time;Training;Woman;Work;Writing

PROJECT_TITLE: Sugar-coating our way to genetically modified mesenchymal stem cells: Glycocalyx-inspired cell culture substrates that prime mesenchymal stem cells for polycation-mediated pDNA delivery.


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Brain Disorders;Cancer;Chronic Pain;Neurodegenerative;Neurosciences;Orphan Drug;Ovarian Cancer;Pain Research;Peripheral Neuropathy;Prevention;Rare Diseases;Women's Health Research

ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: PROJECT NARRATIVE - No Changes have been made Ovarian cancer affects only women for which cisplatin is a commonly used chemotherapeutic drug but it causes neurotoxicity leading to painful neuropathy, cognitive decline, called `chemobrain' and alterations in gait with increased propensity to fall/fractures, which may continue even after the discontinuation of treatment. We hypothesize that the activation of p38 mitogen-activated protein kinase and c-Jun N-terminal kinase plays a critical role in cisplatin-induced damage to the nervous system and that inhibition of these pathways will attenuate cisplatin-induced neurotoxic side effects in female mice with ovarian cancer. We expect that the results of our study will lead to the development of novel therapeutics to reduce the debilitating sequelae of cisplatin in women with ovarian and other cancers.

PI_NAMEs: BOTA, DANIELA ANNENELIE (contact);GUPTA, KALPNA

PROGRAM_OFFICER_NAME: CHEN, WEIWEI

PROJECT_TERMS: Adverse effects;Affect;Aftercare;Alzheimer's Disease;anticancer activity;Antineoplastic Agents;Attention;Attenuated;attenuation;Axon;axon injury;Behavioral;Bioenergetics;blood-brain barrier crossing;Brain;Breast;Breast Cancer Model;C57BL/6 Mouse;Cancer Model;Cancer Patient;cancer therapy;Cell Line;chemobrain;chemotherapeutic agent;chemotherapy;Chemotherapy-induced peripheral neuropathy;Cisplatin;Clinical;Clinical Trials;Cognitive;Cognitive deficits;cognitive testing;Data;Dendritic Spines;density;Development;Diagnosis;disability;Disease Progression;DNA Damage;Dose;druggable target;Electrophysiology (science);Epithelial ovarian cancer;Excitatory Synapse;executive function;experience;falls;FDA approved;Female;Fracture;Gait;health disparity;Hippocampus;Impaired cognition;Impairment;improved;In Vitro;in vivo;Individual;Induced Neurons;Induction of Apoptosis;Inflammation;information processing;inhibitor;Injury;Intervention;Kidney;kinase inhibitor;Length;male;Malignant Breast Neoplasm;Malignant neoplasm of ovary;Malignant Neoplasms;MAPK8 gene;Memory;men;Mitochondria;Mitochondrial DNA;Mitogen-Activated Protein Kinase Kinases;Mitogen-Activated Protein Kinases;Mitogens;Molecular;Morphology;Motor;multidisciplinary;Mus;N-terminal;Nerve;Nerve Fibers;nerve stem cell;Nervous System;neural;Neurologic;neuron apoptosis;Neurons;Neuropathy;neurotoxic;neurotoxicity;neurotransmission;novel;novel strategies;novel therapeutics;Nuclear;Numbness;ototoxicity;Ovarian;Oxidative Stress;Oxygen;p38 Mitogen Activated Protein Kinase;Pain;painful neuropathy;Painful Paresthesias;Pathway interactions;patient mobility;Patients;Performance;Peripheral;Peripheral Blood Stem Cell;peripheral nerve damage;Peripheral Nervous System;Peripheral Nervous System Diseases;Pharmaceutical Preparations;pharmacologic;Phosphotransferases;Platinum Compounds;Play;prevent;Preventive treatment;Process;processing speed;Proto-Oncogene Proteins c-jun;Quality of life;Rattus;Reporting;Rodent Model;Role;Sensory;side effect;Signal Pathway;Signal Transduction;Skin;Small Interfering RNA;small molecule inhibitor;SP600125;Spinal Ganglia;Symptoms;taxane;Testing;Therapeutic;Time;Toxic effect;Transgenic Organisms;translational potential;United States;Vinca Alkaloids;Woman

PROJECT_TITLE: Supplement to Promote Diversity:Targeting p38/JNK MAPK to ameliorate cisplatin-induced adverse sequelae on the nervous system


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE The prevalence of Alzheimer’s disease and related dementias (AD/ADRD) is growing and we observe racial disparities where Black Americans have higher incidence than white Americans. Evidence suggests early life exposures may play a role in the development of AD/ADRD. This administrative proposal will allow us to spatially link social and environmental exposures to Health and Retirement Study participant residences in 1940, with the potential to identify key modifiable factors related to ADRD and ADRD disparities.

PI_NAMEs: CASEY, JOAN A (contact);MAYEDA, ELIZABETH ROSE

PROGRAM_OFFICER_NAME: HARRELL, ERIN

PROJECT_TERMS: Alzheimer's disease related dementia;apolipoprotein E-4;Archives;Black American;caucasian American;Censuses;Cities;Code;Cognitive;Collection;college;Color;Communities;County;Data;Data Files;Data Set;Data Sources;Dementia;Development;Disparity;Documentation;early life exposure;Environmental Exposure;Exposure to;fine particles;Fossil Fuels;Gases;Goals;Health;Health and Retirement Study;Impaired cognition;Incidence;late life;Leadership;Life;Life Cycle Stages;Link;Location;Maps;Measures;Memory Loss;Methodology;Methods;National Archive;Oils;older adult;Output;Paper;parent grant;Parents;Participant;Power Plants;Prevalence;prospective;racial disparity;Research;Research Personnel;Research Project Grants;residence;Resolution;Scanning;social;traffic-related air pollution;Universities;web site;Work

PROJECT_TITLE: Historical social and environmental determinants of memory decline and dementia among U.S. older adults

STUDY_SECTION: SSPB

STUDY_SECTION_NAME: Social Sciences and Population Studies B Study Section[SSPB]


NIH_SPENDING_CATS: Breastfeeding, Lactation and Breast Milk;Digestive Diseases;Immunization;Microbiome;Nutrition;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention;Women's Health Research

ORG_NAME: FRED HUTCHINSON CANCER CENTER

PHR: PROJECT NARRATIVE Mounting evidence links perturbations in early life host-microbiota interactions with increased susceptibility to immune-mediated diseases later in life, yet we lack a mechanistic understanding of how mutually beneficial relationships between gut bacteria and the neonatal immune system are formed. Building from our discovery that maternal antibodies, delivered via breastfeeding, are key regulators of intestinal homeostasis, this proposal seeks to define the cellular and molecular mechanisms by which maternal antibodies restrain aberrant immune responses to gut bacteria in early life. The resulting data will advance our understanding of the immunological processes that regulate nascent host-microbiota interactions, thereby aiding in our ability to manipulate mucosal immune responses in early life to promote long-term health.

PI_NAMEs: KOCH, MEGHAN ANNE (contact)

PROGRAM_OFFICER_NAME: PRABHUDAS, MERCY R

PROJECT_TERMS: adaptive immune response;Adult;Animals;anti-microbial peptide;Antibodies;antigen binding;Antigen-Antibody Complex;Antigens;Area;B-Lymphocytes;Bacteria;Benign;Binding;Breast Feeding;CD4 Positive T Lymphocytes;cell type;Cells;Chemicals;chemokine;Colitis;commensal bacteria;commensal microbes;Complement Activation;Complement Receptor;Data;Dendritic Cells;Development;dietary;Disease;draining lymph node;Education;Equilibrium;Fc domain;Fc Receptor;feeding;Flow Cytometry;Food;Fostering;gastrointestinal epithelium;Goals;gut bacteria;gut inflammation;gut microbes;Health;Health Promotion;Helper-Inducer T-Lymphocyte;Homeostasis;host microbiota;host-microbe interactions;Human;Human Milk;Hypersensitivity;IgG1;IgG3;Immune;immune health;Immune response;Immune System Diseases;Immunity;Immunoglobulin A;Immunoglobulin G;Immunologics;Infant;Inflammation;Inflammatory Bowel Diseases;Inflammatory Response;Ingestion;innovation;insight;intestinal homeostasis;Intestines;Knowledge;Lactobacillus;Lead;Life;Ligation;Link;Maternal antibody;Mediating;mesenteric lymph node;Metabolic dysfunction;microbiota;microbiota composition;microorganism antigen;Milk;Molecular;Morbidity - disease rate;Mothers;mouse model;Mucosal Immune Responses;Mucosal Immune System;Mucosal Immunity;Mucous body substance;Mucous Membrane;mutualism;Neonatal;neonatal immune system;neonatal immunity;neonate;neutralizing antibody;nutrition;offspring;Oral Administration;Ovalbumin;pathogen;Play;Predisposition;prevent;Process;Production;RANTES;receptor function;recruit;Research;resident commensals;response;restraint;Role;Severity of illness;Shapes;Signal Pathway;Signal Transduction;Site;Solid;Specificity;Structure of germinal center of lymph node;suckling;T cell response;Testing;Transgenic Mice;transmission process;Weaning;Work;wound;XCR1 gene

PROJECT_TITLE: Breastmilk antibodies regulate neonatal immunity to the microbiota

STUDY_SECTION: DHMI

STUDY_SECTION_NAME: Digestive System Host Defense, Microbial Interactions and Immune and Inflammatory Disease Study Section[DHMI]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Drug Abuse (NIDA only);Fentanyl Misuse and Addiction;Mental Health;Neurosciences;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_DEPT: ANESTHESIOLOGY

PHR: Project Narrative Withdrawal from persistent opioid use causes an intense negative emotional state, but we do not fully understand the brain systems involved in this response. Prior work identified increased excitatory transmission into a brain region known for producing stress-induced anxiety. The goal of this proposal is to better understand how fentanyl withdrawal modifies this excitatory brain system to drive negative emotional states.

PI_NAMEs: MCCALL, JORDAN G. (contact)

PROGRAM_OFFICER_NAME: NAIR, SUNILA GOPI

PROJECT_TERMS: Affect;Agonist;American;Anxiety;Attention;Aversive Stimulus;avoidance behavior;Behavior;Behavioral;Behavioral Assay;behavioral response;behavioral study;Biological Assay;Brain;Brain region;Cell Nucleus;Cells;Chemicals;Chronic;Clinic;Data;Detection;Electrophysiology (science);excitatory neuron;experimental study;FDA approved;Fentanyl;flexibility;glutamatergic signaling;Glutamates;Goals;Habenula;in vivo;interest;Lateral;Lesion;Link;liquid chromatography mass spectrometry;locus ceruleus structure;Mediating;Microdialysis;Midbrain structure;Modeling;Motivation;mouse model;multidisciplinary;Mus;nano;National Institute of Drug Abuse;negative affect;negative emotional state;Neurobiology;Neurons;neuropsychiatric disorder;Neurosciences;noradrenergic;Nucleus Accumbens;opioid use;opioid withdrawal;optogenetics;patch clamp;Pathway interactions;Persons;postsynaptic;presynaptic;prevent;Prosencephalon;Punishment;Rattus;receptor;Regulation;Research;response;reward processing;Rewards;Risk;Role;Series;Slice;Source;Stimulus;stimulus processing;Stress;Substance Withdrawal Syndrome;success;Synapses;synthetic opioid;System;Targeted Research;Testing;Therapeutic Intervention;Translational Research;transmission process;United States;Ventral Tegmental Area;Viral;voltage clamp;Withdrawal;Work

PROJECT_TITLE: Aversive midbrain glutamatergic regulation of the locus coeruleus during opioid withdrawal

STUDY_SECTION: PMDA

STUDY_SECTION_NAME: Pathophysiological Basis of Mental Disorders and Addictions Study Section[PMDA]


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Gene Therapy;Genetics;Immunotherapy;Neurosciences;Rare Diseases

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: PROJECT NARRATIVE Project Narrative is not required for NCI Diversity Supplement. This is an NCI Diversity Supplement to Dr. Juan Fueyo-Margareto’s NCI grant, R01 CA256006, titled, “Glioma therapy with oncolytic adenoviruses and immunometabolic adjuvants.”

PI_NAMEs: FUEYO, JUAN  (contact);GOMEZ-MANZANO, CANDELARIA

PROGRAM_OFFICER_NAME: BOURCIER, KATARZYNA

PROJECT_TERMS: Address;Adjuvant;Area;Aryl Hydrocarbon Receptor;Award;Brain;Brain Neoplasms;cancer therapy;career development;Cells;clinical development;Clinical Research;Combined Modality Therapy;cytotoxic;Data;Drug Industry;Environment;Foundations;Gene Expression Profiling;Glioma;Grant;Immune;Immune response;Immune system;Immunocompetent;Immunosuppression;Infection;inhibitor;innovation;Lymphocyte;Malignant Glioma;Mediating;Metabolic;Modeling;Myeloid Cells;neoplastic cell;novel;oncolytic adenovirus;Operative Surgical Procedures;Pathway interactions;Patients;Population;Prognosis;receptor expression;Research;Research Project Grants;Shapes;Specimen;T-Cell Activation;Testing;Time;Toxic effect;Training;tumor;tumor microenvironment;Virus Diseases

PROJECT_TITLE: NCI Diversity Supplement: Glioma therapy with oncolytic adenoviruses and immunometabolic adjuvants

STUDY_SECTION: DT

STUDY_SECTION_NAME: Developmental Therapeutics Study Section[DT]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Neurosciences

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: This proposed project will lead to a novel two-photon miniaturized microscope that can simultaneously record and manipulate neural activity in freely-behaving mice with high spatial and temporal resolution over a large brain volume. The microscope will be compact and light-weight, and can be mounted on the mice head. This project will enable neuroscientists to mechanistically study the brain circuit under the mice’s natural behavior.

PI_NAMEs: YANG, WEIJIAN  (contact)

PROGRAM_OFFICER_NAME: ANDERSON, AFROUZ AZARI

PROJECT_TITLE: Simultaneous two-photon imaging and two-photon manipulation of neural activity in freely behaving mice

STUDY_SECTION: BNVT

STUDY_SECTION_NAME: Bioengineering of Neuroscience, Vision and Low Vision Technologies Study Section[BNVT]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Mental Health;Neurodegenerative;Neurosciences;Precision Medicine;Prevention

ORG_CITY: PROVIDENCE

ORG_NAME: RHODE ISLAND HOSPITAL

ORG_STATE: RI

PHR: PROJECT NARRATIVE Alzheimer’s disease will affect an estimated 14 million Americans by the year 2050, contributing to economic burden and reduced quality of life for patients and caregivers. As the U.S. population ages, it is critically important to identify who is at greatest risk for Alzheimer’s disease-associated cognitive decline. Studying novel markers of risk for cognitive decline in cognitively normal older adults may identify those who would benefit most from early detection and treatment strategies for Alzheimer’s disease.

PI_NAMEs: KORTHAUER, LAURA  (contact)

PROGRAM_OFFICER_NAME: WAGSTER, MOLLY V

PROJECT_TERMS: Affect;Age;Aging;Alzheimer disease detection;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease risk;American;Area;Behavioral;biomarker validation;Brain;career development;Caregivers;Clinical;Clinical Research;Cognition;Cognitive;cognitive neuroscience;cognitive reserve;cohort;complex data;Development;Development Plans;dimension reduction;dimensional analysis;Early Diagnosis;Early treatment;Economic Burden;Electroencephalography;Electrophysiology (science);experience;Fostering;Goals;Impaired cognition;indexing;Infrastructure;Knowledge;laboratory experience;Magnetic Resonance Imaging;Measures;Mentorship;Monitor;Neuroanatomy;Neurocognitive;Neuropsychology;novel;novel marker;older adult;Patients;Population;pre-clinical;Public Health;Quality of life;Registries;Research;Research Activity;Research Design;Research Personnel;Research Project Grants;resilience;Rhode Island;Risk Marker;risk prediction;Statistical Methods;statistics;Technical Expertise;Training;Training Activity;treatment strategy

PROJECT_TITLE: Novel Neurocognitive Markers of Risk for and Resilience to Cognitive Decline in Preclinical Alzheimer's Disease


NIH_SPENDING_CATS: Aging;Bioengineering;Cancer;Data Science;Machine Learning and Artificial Intelligence;Neurosciences

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE The NEXUS U24 Coordinating Center for Exposome Research will serve as a resource for the biomedical community to facilitate the use of exposomic methods and approaches in all human diseases and conditions.

PI_NAMEs: HABRE, RIMA ;MILLER, GARY W (contact);PATEL, CHIRAG J.

PROGRAM_OFFICER_NAME: NADADUR, SRIKANTH

PROJECT_TERMS: Artificial Intelligence;Belief;Biological;biomedical resource;Calibration;Chemicals;Chemistry;Coin;Communities;Community of Practice;Complement;Data;data repository;Data Science;Democracy;design;digital;Discipline;Disease;Ecosystem;education resources;Educational workshop;Environment;Environmental Health;Equation;experience;Funding;Funding Agency;Future;Genes;Genomics;Goals;Health;Human;human disease;Individual;Informatics;Infrastructure;innovation;Lead;life span;Life Style;Machine Learning;Measurement;Measures;member;Meta-Analysis;Methods;Modeling;Molecular Bank;Outcome;Personal Satisfaction;Persons;Population;Public Health;Recommendation;Research;Research Infrastructure;Research Personnel;Resources;Sampling;scaffold;Science;social;social influence;Standardization;Structure;Techniques;Technology;Time;tool;United States National Institutes of Health;Vision;web site

PROJECT_TITLE: NEXUS: Network for Exposomics in the U.S.

STUDY_SECTION_NAME: Special Emphasis Panel[ZES1 LWJ-K (U)]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Genetics;Human Genome;Rare Diseases

PHR: Project Narrative Many cancers have alterations in genetic pathways for repairing DNA damage that leave them sensitive to specific treatments. However, we are currently unable to reliably determine which genetic defects are present in a given cancer sample, which limits our ability to exploit these therapeutic vulnerabilities. Here we will make use of hitherto unexplored genomic features and novel statistical techniques to distinguish between cancers with different genetic alterations and identify clinically relevant biomarkers.

PI_NAMEs: RASKIND, GREGORY  (contact)

PROGRAM_OFFICER_NAME: PURI, ANU

PROJECT_TERMS: Affect;Aftercare;Algorithms;Alkylating Agents;base;Biological Markers;Biological Process;BRCA1 gene;BRCA2 gene;cancer cell;cancer diagnosis;cancer genome;cancer type;candidate identification;candidate validation;Categories;Cause of Death;Cell Line;Characteristics;chemotherapy;Chromatin;Classification;Clinical;clinically relevant;cohort;Complex;complex modeling;Computer Models;Computing Methodologies;Data;Data Set;deep sequencing;Defect;design;Detection;detection method;DNA Damage;DNA Markers;DNA Repair;DNA Repair Gene;DNA Repair Pathway;DNA Sequence Rearrangement;Double Strand Break Repair;Endometrial Carcinoma;Engineering;epigenetic silencing;follow-up;Genes;Genetic;Genetic Models;Genome;Genomics;Glioblastoma;Glioma;glioma cell line;Guanine + Cytosine Composition;homologous recombination deficiency;Human;Immunotherapy;improved;In Vitro;Laboratories;Length;Letters;Malignant Neoplasms;Methods;MGMT gene;Mismatch Repair Deficiency;Modeling;Molecular Conformation;Mutation;novel;Pathway interactions;Pattern;Platinum;Poly(ADP-ribose) Polymerase Inhibitor;PRKDC gene;Process;RAD52 gene;repaired;response;Sampling;Single base substitution;Structural Models;Structure of retinal pigment epithelium;targeted treatment;Techniques;Testing;Therapeutic;tumor;Variant;whole genome;Work

PROJECT_TITLE: Elucidating Signatures of DNA Damage Response Alterations from Structural Variants in Human Cancer


ORG_CITY: CHICAGO

ORG_NAME: PREVENT CHILD ABUSE AMERICA

ORG_STATE: IL

PHR: Project Narrative There exists a large gap in the scientific evidence base related to how state-level, economic supports (ES) policy options (i.e., state-level refundable Earned Income Tax Credit, paid family leave, child care subsides, Child Tax Credit, and minimum wage) collectively impact violence against children (i.e., child maltreatment [CM] and intimate partner violence [IPV]) (Fortson et al., 2016; Niolon et al., 2017; Puls et al. 2021). We propose a rigorous evaluation of the combined effects of state-level ES ‘policy ecosystems’ (i.e., multiple, co-occurring, ES policy options) on rates of CM and IPV through a through a systematic review of the extant literature linking state-level ES policy options with CM and IPV (Aim 1), a data-driven, landscape assessment of within and between state variation in ES policy ecosystems across time (2002- present) (Aim 2), and quasi-experimental, multilevel time-series analyses examining the impact of shifting state-level ES policy ecosystems on the within-state reduction of CM and IPV (Aim 3). Results from these analyses will provide new insights into the collective effects of state ES policy options, furthering evidence for addressing societal factors as a strategy in the primary prevention of CM and IPV.

PI_NAMEs: KLIKA, JEFFRY BART;THIBODEAU, ERIC L (contact)

PROJECT_TITLE: RFA-CE-24-034: Evaluating the Effects of Ecosystems of State Policy Strategies on Preventing Multiple Forms of Violence Against Children

STUDY_SECTION_NAME: Special Emphasis Panel[ZCE1 TQD (01)]


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: BIRMINGHAM

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Project Narrative The parent research project and proposed supplement is highly relevant to public health in its ability to determine the role of motherhood biographies as a key mechanism in explaining racial-ethnic and socioeconomic health disparities among midlife women, particularly aging Black women. This proposed supplemental research will identify the most health-disadvantaged subpopulations of midlife mothers and nonmothers with attention to differences at the intersec- tion of race-ethnicity and socioeconomic status. In doing so, this R01 informs interventions and public policies designed to improve women’s health and reduce racial-ethnic health disparities in midlife and beyond, a key goal of NIA, while contributing to the development of a minority junior scholar specifically in the area of aging and life course research.

PI_NAMEs: RECZEK, RIN ;THOMEER MCBRIDE, MIEKE BETH (contact)

PROGRAM_OFFICER_NAME: BRAUDT, DAVID BRUCE

PROJECT_TERMS: Administrative Supplement;Adult Children;Age;Aging;aging related;Agreement;Area;Attention;Benchmarking;Biography;Black race;black women;Budgets;career;Career Choice;career development;Characteristics;Child;Cognitive;Consultations;Data;Data Analyses;design;Development;Dimensions;Disadvantaged;Doctor of Philosophy;Education;ethnic health disparity;Ethnic Origin;experience;Faculty;falls;Feedback;Fellowship;First Births;Fostering;Funding;Gerontology;Goals;Grant;Health;Health behavior;Health Disparities Research;health disparity;human capital;improved;Intervention;Journals;Life Cycle Stages;longitudinal analysis;Longitudinal Studies;Maps;Mediation;meetings;member;Mentors;Mentorship;Methods;middle age;Midlife women;Minority;Mother-Child Relations;motherhood;Mothers;Occupations;Ohio;Oral;Outcome;parent grant;parent project;Parents;Pathway interactions;Peer Review;Persons;Population;Population Research;Positioning Attribute;post-doctoral training;Postdoctoral Fellow;programs;Progress Reports;Psyche structure;Public Health;Public Policy;Publications;Publishing;Race;Research;Research Activity;research data dissemination;Research Project Grants;Resources;Role;Scholarship;Scientist;Shapes;Societies;Socioeconomic Status;socioeconomics;Sociology;spelling;Statistical Methods;symposium;tenure track;Testing;theories;Training;Travel;United States National Institutes of Health;Universities;Woman;Women's Health;Work;Writing;Youth

PROJECT_TITLE: Motherhood Biographies and Midlife Women's Health


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: PISCATAWAY

ORG_DEPT: GENETICS

ORG_NAME: RUTGERS, THE STATE UNIV OF N.J.

ORG_STATE: NJ

PHR: PROJECT NARRATIVE Alterations of a microtubule-binding protein tau are one of hallmarks of Alzheimer’s disease (AD), with progressive memory deficits being one of its major symptoms. Tau is key facilitator of neuronal transport, mediated by microtubules, and regulation of the microtubule cytoskeleton and microtubule-mediated transport is implicated in AD. Because changes in microtubule stability are critical for synapse function and memory and are disrupted in AD, we propose to examine how manipulations of microtubule stability affect microtubule- mediated synaptic protein localization, synaptic function and memory in mice modeling some of the AD-related mechanisms.

PI_NAMEs: ALARCON, JUAN MARCOS;SHUMYATSKY, GLEB P (contact)

PROGRAM_OFFICER_NAME: LI, TONG

PROJECT_TERMS: Adult;Affect;Alzheimer's Disease;Alzheimer's disease model;Amyotrophic Lateral Sclerosis;Area;Behavioral;Binding;Binding Proteins;Brain;Cells;Cognition;conditioned fear;Cytoskeleton;Dementia;Development;Dorsal;experimental study;Family;gain of function;Goals;Hippocampus;Histologic;improved;Injections;knockout gene;Learning;long term memory;loss of function;Mediating;member;Memory;memory consolidation;Memory impairment;Memory Loss;Microtubule Stabilization;Microtubule-Associated Proteins;Microtubules;mouse model;Mus;mutant;Mutation;neuronal transport;new therapeutic target;normal aging;novel;Outcome Study;Pathology;Phase;phase change;Phosphoproteins;Phosphorylation;Post-Translational Protein Processing;Process;Proteins;Regulation;Role;Signal Pathway;stathmin;Stathmin Pathway;Symptoms;Synapses;synaptic function;Synaptic plasticity;Synaptic Transmission;Synaptosomes;tau Proteins;Testing;Time;Training;transcriptomics;Tubulin;Work

PROJECT_TITLE: The role of microtubule network in a mouse model of Alzheimer’s disease

STUDY_SECTION: CDIN

STUDY_SECTION_NAME: Chronic Dysfunction and Integrative Neurodegeneration Study Section[CDIN]


NIH_SPENDING_CATS: Asthma;Biotechnology;Chronic Obstructive Pulmonary Disease;Clinical Research;Emphysema;Genetics;Lung

ORG_NAME: WASHINGTON UNIVERSITY

PHR: Project Narrative/Public Health Relevance for Parent Grant Chronic Obstructive Pulmonary Disease is a major cause of morbidity worldwide and the 3rd leading cause of death in the United States. There are no cures for this disease and the standard forms of treatment often do not provide adequate relief, as much of the morbidity and mortality is due to mucus obstruction of the airways. There are currently no specific and effective therapies available for excess mucus production. The proposed work aims to identify new ways to treat this disorder by investigating the source of inflammation and mucus overproduction in the airways, thereby addressing a previously unmet need for treatment of a major public health problem. Project Narrative/Public Health Relevance for Supplement Chronic Obstructive Pulmonary Disease is a major cause of morbidity worldwide and the 3rd leading cause of death in the United States. There are no cures for this disease and the standard forms of treatment often do not provide adequate relief, as much of the morbidity and mortality is due to mucus obstruction of the airways. The proposed work aims to identify new ways to detect and potentially treat this disorder by investigating the source of inflammation and mucus overproduction in the airways, thereby addressing a previously unmet need for treatment of a major public health problem.

PI_NAMEs: ALEXANDER-BRETT, JENNIFER  (contact)

PROGRAM_OFFICER_NAME: LIU, QIAN

PROJECT_TERMS: Address;Administrative Supplement;Airway Disease;airway epithelium;airway obstruction;Allergens;Alternative Splicing;Animal Model;Antibodies;antibody detection;Asthma;Biological Assay;Biology;Cause of Death;Cell model;Cells;Chronic;Chronic Bronchitis;Chronic Obstructive Pulmonary Disease;chronic respiratory disease;Clinical Research;Coupled;cytokine;Data;Development;Disease;disease model;effective therapy;Enzyme-Linked Immunosorbent Assay;Epithelial Cells;Epithelium;Exons;exosome;Foundations;Human;Hybridomas;Immunization;in vivo;Inflammation;Knowledge;Lower respiratory tract structure;Measurement;Mediating;Molecular Chaperones;Monoclonal Antibodies;Morbidity - disease rate;mortality;mouse model;Mucous body substance;Mucous Membrane;Mus;novel;novel marker;Nuclear;parent grant;Pathogenesis;Pathogenicity;Pathologic;Pathway interactions;Phosphorylation;Post-Translational Protein Processing;Production;Protein Isoforms;Protein Kinase C;Public Health;public health relevance;Pulmonary Emphysema;Receptor Activation;Research;Respiratory Tract Diseases;RNA Splicing;Role;screening;Smoke;Source;Specimen;Structure of parenchyma of lung;Therapeutic;Therapeutic Intervention;trafficking;translational study;United States;Validation;Variant;Virus;Work

PROJECT_TITLE: Non-Classical Cytokine Secretion in Chronic Airway Disease


ORG_CITY: PHILADELPHIA

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative PHLHousing+ -- a housing-focused guaranteed income experiment – provides a unique opportunity to test whether unconditional monthly cash payments, Housing Choice Vouchers, or both reduce exposure to violence for low income renters who, in the City of Philadelphia, are disproportionately Black. Data from randomized controlled trials of housing programs are sorely needed to evaluate effects on exposure to violence in the family and the community. Study findings will have immediate implications for the City of Philadelphia's model for providing housing assistance, will inform efforts to establish similar programs in other cities as well as federal approaches to rental assistance, and will provide actionable information about the effectiveness of targeting housing security in efforts to prevent exposure to violence.

PI_NAMEs: JAFFEE, SARA R (contact);REINA, VINCENT J.

PROJECT_TITLE: RFA-CE-24-034 :Evaluating the impact of PHLHousing+ on child welfare involvement


NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: COLUMBUS

ORG_NAME: RESEARCH INST NATIONWIDE CHILDREN'S HOSP

PHR: PROJECT NARRATIVE Infantile rhabdomyosarcoma (RMS) is a newly identified and poorly understood aggressive pediatric muscle cancer that affects young children. There is one single mutation that causes the disease, but we do not have specialized treatments targeting this genetic event, and patients are treated with general strategies that are often ineffective or have harsh life-long side effects. We will leverage novel zebrafish and mouse cancer models to help young children with cancer by understanding the biology of how infantile RMS develops and implementing these models to identify clinically tractable therapeutic targets.

PI_NAMEs: KENDALL, GENEVIEVE CLAIRE (contact)

PROGRAM_OFFICER_NAME: WITKIN, KEREN L

PROJECT_TERMS: Actins;Address;ADP-ribosylation factor 6;Affect;Allografting;Alveolar Rhabdomyosarcoma;Animal Model;Animals;Binding;Biochemical;Biology;Cancer Biology;Cancer Model;Cell Culture Techniques;Cell Line;Cell Lineage;Cells;chemotherapy;Child;Childhood;Chromatin;Classification;Clinical;clinical care;clinical sequencing;comparative;Complex;Data;Development;Developmental Biology;Developmental Gene;Disease;druggable target;Embryonal Rhabdomyosarcoma;Endocytic Vesicle;Event;FOXO1A gene;Gene Expression Profile;Gene Fusion;Genetic;Genetic Diseases;Genetic Transcription;Genomics;Goals;Human;human disease;infancy;innovation;Knock-out;Knowledge;Malignant Childhood Neoplasm;malignant muscle neoplasm;Malignant Neoplasms;Maps;Mediating;Modeling;Molecular;Monomeric GTP-Binding Proteins;Mus;Muscle;Muscle Development;mutant;Mutation;Myoblasts;myogenesis;NCOA2 gene;novel;novel therapeutic intervention;Nuclear Receptors;Oncogenes;Oncogenic;Oncology;Operative Surgical Procedures;overexpression;Pathway interactions;patient derived xenograft model;Patients;PAX3 gene;Predisposition;progenitor;programs;Property;Radiation;Research;Rhabdomyosarcoma;Role;Sampling;Series;side effect;Skeletal Muscle;small molecule;spatiotemporal;Structure;System;targeted treatment;Tertiary Protein Structure;Testing;Therapeutic;therapeutic target;Transcription Coactivator;transcription factor;Transgenic Organisms;tumor;tumor initiation;tumorigenesis;tumorigenic;Validation;Zebrafish;zebrafish development

PROJECT_TITLE: Understanding Infantile Rhabdomyosarcoma Biology and Therapeutic Targets


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_DEPT: BIOLOGY

PHR: Project Narrative Daily rhythms in rest-activity and physiology are well-known. This proposal will test the roles of specific cells and functional connections in the brain’s central circadian pacemaker for adaptation to long and short days.

PI_NAMEs: HERZOG, ERIK  (contact)

PROGRAM_OFFICER_NAME: HE, JANET

PROJECT_TERMS: Ablation;Address;Behavior;behavioral response;Brain;brain cell;Calcium;Cell Communication;Cell Nucleus;cell type;Cells;circadian;circadian pacemaker;Complex;Computational Biology;Computer Models;control theory;Coupling;Cues;Darkness;Data;Data Science;day length;Dorsal;dynamic system;Engineering;Environment;Evaluation;experience;experimental study;Exposure to;Feedback;Female;Food;Foundations;Gene Expression;gene function;Genes;Goals;Guidelines;Hormone secretion;In Vitro;in vivo;insight;intercellular communication;Learning;Light;male;Maps;Measures;Mediating;Methods;Modeling;Mus;neural;neural circuit;Neurobiology;Neurons;Neurosciences;novel;optogenetics;Output;Ovulation;Partner in relationship;Pattern;Performance;Phase;Photoperiod;photoperiodicity;Physiology;Protocols documentation;reconstruction;Resolution;response;Rest;Role;Science;Seasonal Variations;Seasons;sex;sexual dimorphism;Sleep;statistics;Structure;suprachiasmatic nucleus;System;Techniques;Testing;Time;Vertebrates

PROJECT_TITLE: Functional Connectivity in the Circadian Clock

STUDY_SECTION: BNRS

STUDY_SECTION_NAME: Behavioral Neuroendocrinology, Neuroimmunology, Rhythms, and Sleep Study Section [BNRS]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dental, Oral, and Craniofacial Disease;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Social Determinants of Health

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Project Narrative Persistent no-show rates contribute to the oral health disparities and inadequate access to dental care that disproportionately affect underserved populations. The proposed research will test the impact of three different strategies on no-show rates using an innovative full factorial design and a standardized implementation approach called the NIATx model. Findings from this study seek to provide an evidence-based approach to reducing no-shows and increasing access to dental care for underserved populations.

PI_NAMEs: MOLFENTER, TODD DAVID (contact);OKUNSERI, CHRISTOPHER ;SZABO, ANIKO

PROGRAM_OFFICER_NAME: MATTIA, JILL

PROJECT_TERMS: Address;Admission activity;Affect;Appointment;Appointments and Schedules;care delivery;Caring;Clinic;Clinical;Clinical Trials;Cluster randomized trial;college;Communities;data quality;Dental;Dental Care;Dental Clinics;design;effectiveness testing;efficacy/implementation trial;Engineering;Ensure;Ethnic Origin;evidence base;Evidence based practice;experience;Goals;Health;health care service organization;health care settings;health disparity;Health Services;Health Services Accessibility;Healthcare;Hour;implementation facilitation;improved;innovation;Intervention;Intervention Studies;Manuals;Mediating;Medical;Methods;Modeling;motivational enhancement therapy;operation;Operative Surgical Procedures;Oral health;Organizational Change;organizational readiness;Patient Appointment;patient population;Patients;Performance;Pilot Projects;prevention practice;Process;process improvement;Protocols documentation;Quality of Care;Race;Randomized;Recommendation;recruit;Reduce health disparities;Reporting;Research;Research Design;Research Personnel;Resources;Role;Schedule;School Dentistry;service organization;Services;Site;Standardization;Structure;System;Team Process;Techniques;Testing;Time;tool;treatment as usual;Underserved Population;United States;Universities;virtual visit;Visit;Wisconsin

PROJECT_TITLE: No-Show Prevention Practices in Dental Care Settings Serving Underserved Populations


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza;Rare Diseases

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: Project Narrative Inflammation underlies the pathology of almost all diseases and can be both resolving and damaging in tissues. In inflammatory lung diseases, cells of the immune system are recruited and migrate into tissue, where they can perform complex functions. A better understanding of the migration of these cells into the lungs during inflammatory airspace lung diseases may improve our ability to understand and treat conditions like bronchopneumonia and gastric aspiration.

PI_NAMEs: HAYNES, MAUREEN  (contact)

PROGRAM_OFFICER_NAME: ESPINOZA-PINTUCCI, MARISOL

PROJECT_TERMS: Acute;Acute Lung Injury;Adhesions;adverse outcome;Affect;Alveolar;Alveolar Macrophages;Anti-Inflammatory Agents;Antibiotics;aspirate;Aspiration Pneumonia;Bacteria;Bacterial Model;Beds;Behavior;Blood;Bronchoalveolar Lavage;Bronchopneumonia;CD31 Antigens;Cell Adhesion Molecules;cell motility;cell type;Cells;Cessation of life;Chemicals;Circulation;Complex;Crowding;Data;Dependence;Disease;Disease Outcome;Disease Progression;Edema;Endothelial Cells;Endothelium;Enzyme-Linked Immunosorbent Assay;Flow Cytometry;Gases;Gram-Negative Bacteria;granulocyte;Health;High Prevalence;Histologic;Hospitalization;Hour;immune cell infiltrate;Immune response;Immune system;Impairment;improved;Individual;Infection;Infiltration;Inflammation;Inflammatory;inflammatory lung disease;Inflammatory Response;Injury;insight;Integrins;intravital microscopy;Knowledge;Leukocytes;Location;Lung;Lung Diseases;lung injury;Macrophage;Mediator;migration;Molecular Analysis;monocyte;mortality;mouse model;Mus;neutrophil;Oropharyngeal;Pathology;Patients;Pattern;Persons;Physiological;Play;Pneumonia;Population;Prevalence;Preventive therapy;Process;Pseudomonas aeruginosa;Pulmonary Pathology;recruit;response;Role;Sampling;Selectins;Site;Stimulus;Stomach;Stomach Content;Streptococcus pneumoniae;superinfection;Supportive care;Symptoms;Therapeutic Intervention;Therapeutic Uses;Time;Tissues;vascular bed;Visualization;Work

PROJECT_TITLE: Defining the temporospatial functions of neutrophils in acute airspace disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F10A-R (08)]


FUNDING_MECHANISM: RESEARCH CENTERS

PHR: NARRATIVE Ovarian cancer is a significant cause of morbidity and mortality that affects nearly 300,000 women worldwide each year, and its poor outcomes are related to delayed diagnosis and development of resistance to conventional therapy with carboplatin, paclitaxel and PARP inhibitors. We have discovered that GRN-300, a SIK-2 inhibitor, enhances PARP inhibitor olaparib activity. The proposed research will improve outcomes for women with ovarian cancer by understanding the underlying mechanisms by which GRN-300 overcomes olaparib resistance in ovarian cancer and will provide initial proof-of concept for a novel therapeutic approach.

PI_NAMEs: BAST, ROBERT C;SOOD, ANIL K (contact)

PROGRAM_OFFICER_NAME: BASA JANAKIRAM, NAVEENA

PROJECT_TERMS: Affect;Binding;cancer cell;Cancer cell line;cancer immunotherapy;Cancer Model;Carboplatin;CD8-Positive T-Lymphocytes;Cell Physiology;checkpoint therapy;Chromatin;conventional therapy;cytotoxicity;Diagnosis;DNA Repair;DNA Repair Gene;DNA Repair Pathway;Enhancers;experience;first-in-human;Frequencies;Gene Expression;Genetic Transcription;Goals;HDAC4 gene;homologous recombination;homologous recombination deficiency;Human;immune checkpoint blockade;Immunotherapy;improved outcome;inhibitor;IRF3 gene;Malignant neoplasm of ovary;Malignant Neoplasms;Marrow;Maximum Tolerated Dose;Morbidity - disease rate;mortality;mouse model;Mus;Muscle Cells;Myelosuppression;novel;novel therapeutic intervention;Nuclear;Nucleic Acid Regulatory Sequences;Outcome;Ovarian;Paclitaxel;Pathway interactions;Patients;Phase;Phase I Clinical Trials;Phase Ib Trial;Phosphorylation;Phosphotransferases;Play;Poly(ADP-ribose) Polymerase Inhibitor;Polymerase;preclinical study;programmed cell death ligand 1;Progression-Free Survivals;Relapse;Repression;Research;Resistance;Resistance development;response;Site;Sodium Chloride;Stimulator of Interferon Genes;T cell infiltration;T-Lymphocyte;targeted agent;TBK1 gene;Toxic effect;tumor;Woman;women's outcomes;Xenograft procedure

PROJECT_TITLE: The SIK2 Inhibitor GRN-300 enhances PARP Inhibitor sensitivity and overcomes resistance by blocking homologous recombination (HR) DNA repair in ovarian cancer