NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Physical Activity

ORG_CITY: PITTSBURGH

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative / Relevance The role of anti-aging protein Klotho in neurodegeneration and impaired cognition is poorly understood. The proposed research will determine who are the mediators of the effects of physical exercise at gene and cell level in brain the role of Klotho and how the Choroid Plexus epithelial cells facilitate the communications between peripheral muscles and brain through Blood CSF Barrier. We will investigate the role of Klotho using mice with global deletion of Klotho, complex mice expressing human APP expressing one only allele of Klotho, and procedures to isolate and profile extracellular vesicles, primarily exosomes, from plasma and CSF. The in vitro models proposed will address the question if, and how the aging brain with lower expression of Klotho, and the aging muscles with lower Klotho in exosomes released in response to physical exercise affect the brain function.

PI_NAMEs: AMBROSIO, FABRISIA ;KOLDAMOVA, RADOSVETA  (contact)

PROGRAM_OFFICER_NAME: PETANCESKA, SUZANA

PROJECT_TERMS: Acute;Aerobic Exercise;Affect;age related;age related changes;age related decline;Aging;aging brain;Alleles;Alzheimer like pathology;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease patient;Alzheimer's disease risk;Amyloid;Animal Disease Models;Animal Model;anti aging;Behavioral;Bioenergetics;Biology;Blood;Brain;Cells;Cellular biology;Characteristics;Choroid Plexus Epithelium;Circulation;Cognition;Cognitive;cognitive function;cognitive performance;Communication;Complex;Data;Diet;Disease associated microglia;disease model;Environmental Risk Factor;Epithelial Cells;Exercise;exosome;experience;extracellular vesicles;Gene Expression;Genes;Genetic;Goals;Hippocampus;Human;Impaired cognition;Impairment;improved;In Vitro;in vitro Model;Infiltration;Inflammatory;Injections;Interdisciplinary Study;Kidney;klotho protein;Laboratories;Late Onset Alzheimer Disease;Life Style;Link;Longevity;Macrophage;Maintenance;Mediating;Mediator;Memory;Messenger RNA;MicroRNAs;Molecular;Morphology;mouse model;mRNA Expression;Mus;Muscle;muscle aging;Muscle Cells;Muscle Contraction;muscle progenitor cell;muscle regeneration;Nerve Degeneration;neural;Neurodegenerative Disorders;neuromuscular stimulation;neuroprotection;NIH Program Announcements;novel;Outcome;overexpression;Pathogenesis;Peripheral;Phenotype;Physical activity;Physical Exercise;Plasma;Procedures;programs;Proteins;Proteomics;Rattus;Regulation;Rehabilitation therapy;Reporting;Research;Research Design;Research Personnel;resilience;response;Risk;Risk Factors;Role;Running;Senile dementia;Signal Transduction;Skeletal Muscle;Skeletal muscle injury;Structure of choroid plexus;System;Testing;Time;Training;transcriptome;Transgenic Mice;transmission process;treadmill;Up-Regulation

PROJECT_TITLE: Physical exercise and Blood-brain communication: exosomes, Klotho and choroid plexus


ADMINISTERING_IC: AG

ARRA_FUNDED: N

ED_INST_TYPE: UNIVERSITY-WIDE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Depression;Mental Health;Neurodegenerative;Neurosciences;Telehealth

ORG_CITY: PORTLAND

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: NARRATIVE This study addresses a high-priority public health need by leveraging technology to reduce distress for family members caring for those with moderate to late stage Alzheimer's disease or a related dementia. The proposed study tests the feasibility, acceptability and efficacy of the video-conference-based Tele-STELLA intervention, using a novel dissemination vehicle, across three sites (Oregon, Kentucky and Georgia). The overarching goal is to increase access to Tele-STELLA, which has the potential to help reduce the stress of the 16 million care partners in the US providing care for a family member with dementia.

PI_NAMEs: LINDAUER, ALLISON  (contact)

PROGRAM_OFFICER_NAME: RIDDLE, MELISSA

PROJECT_TERMS: acceptability and feasibility;Address;Affect;Affective Symptoms;African American;Alzheimer's Disease;Alzheimer's disease related dementia;Anxiety;barrier to care;Behavioral;Behavioral Symptoms;Binding;care burden;care outcomes;care recipients;Caring;Cognitive;Communication;Community Healthcare;Computers;cost;Coupled;Cultural Backgrounds;Data;Dementia;design;Development;Disease;Disease Progression;Distress;Education;Educational Intervention;Educational process of instructing;experience;Family;family caregiving;Family member;feasibility testing;Feedback;Focus Groups;Foundations;Frequencies;Goals;Grief reaction;Health;Home;improved;Incentives;Individual;Internet;Intervention;Kentucky;Learning;Life;Linear Regressions;Link;Long-Term Care;Measures;Mental Depression;Methods;Modeling;novel;Nurses;Oregon;Participant;peer;peer support;personalized approach;Persons;Pharmaceutical Preparations;Pilot Projects;Planet Earth;Positioning Attribute;Process;programs;Protocols documentation;Psyche structure;psychoeducational intervention;psychologic;psychological symptom;Psychologist;public health priorities;Quality of life;Randomized, Controlled Trials;Recommendation;recruit;Research Personnel;Risk;Rural;Science;Scientist;Site;skills;social stigma;Stress;stress reduction;Symptoms;Techniques;Technology;technology intervention;telehealth;Testing;therapy design;Time;Training;United States;United States National Institutes of Health;Universities;videoconference;Videoconferencing;Videotape;web-based intervention;Work

PROJECT_TITLE: Using Technology to Support Care Partners for Persons with Alzheimer's Disease:  Tele-STELLA

STUDY_SECTION: CMPC

STUDY_SECTION_NAME: Clinical Management of Patients in Community-based Settings Study Section[CMPC]


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Dissemination and Implementation Research;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Networking and Information Technology R&D (NITRD);Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse;Telehealth

ORG_CITY: MADISON

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE / PUBLIC HEALTH RELEVANCE People living with substance use disorders and people from racial and ethnic minority groups make up a disproportionate share of new HIV infections in the United States, and once diagnosed, they are less likely to achieve and maintain viral suppression. These disparities reflect complex social and structural determinants of health, which can be addressed by existing medical and social services only if they are accessible, culturally appropriate, and delivered to patients when and where they are needed. This project will test the effectiveness of a combination of strategies, including an evidence-based mobile health app and peer mentoring, that can be integrated into an HIV clinical practice to improve viral suppression and retention in care for vulnerable patients.

PI_NAMEs: QUANBECK, ANDREW ;WESTERGAARD, RYAN PATRICK (contact)

PROGRAM_OFFICER_NAME: FITZ-RANDOLPH, MARCY ESTHER

PROJECT_TERMS: addiction;Address;Adherence;Adoption;alcohol misuse;antiretroviral therapy;Appointment;Award;Awareness;barrier to care;behavior change;Behavioral;care coordination;Caring;Cellular Phone;Cities;Clinic;Clinical;clinical care;clinical practice;Cluster randomized trial;Collaborations;Colorado;Communities;Complex;Cost Effectiveness Analysis;Cost Measures;Costs and Cost Analysis;Criminal Justice;Data;design;Diagnosis;Disparity;Drug usage;Effectiveness of Interventions;effectiveness testing;effectiveness/implementation study;electronic health record system;Epidemic;ethnic disparity;ethnic minority population;evidence base;experience;Failure;food insecurity;Foundations;Funding;Future;Geography;Goals;Health;health equity;Health Services Accessibility;Health system;HIV;HIV Infections;HIV/AIDS;Home;Housing;Hybrids;implementation cost;implementation evaluation;implementation trial;improved;Incidence;Infrastructure;innovation;interdisciplinary approach;Internet;Intervention;intervention refinement;Intervention Trial;intrinsic motivation;Life Cycle Stages;Maintenance;Medical;medication compliance;member;Mental Health Services;mHealth;mhealth interventions;Minority Groups;Missouri;mobile computing;Mobile Health Application;Modeling;Monitor;novel strategies;patient centered medical home;Patient Education;patient oriented;Patient Recruitments;Patients;peer;peer coaching;peer support;person centered;Persons;Population;prevent;primary outcome;programs;Provider;provider communication;psychological distress;public health relevance;quality assurance;racial disparity;racial minority population;randomized trial;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Research;response;secondary outcome;Secure;service organization;Services;Site;skills;social;social determinants;social health determinants;Social support;Social Work;Solid;structural health determinants;substance use;Substance Use Disorder;Support System;System;Testing;Texas;Time;tool;transmission process;treatment adherence;Treatment outcome;United States;United States National Institutes of Health;Viral;Wisconsin;Work

PROJECT_TITLE: Clinic-level implementation of mHealth to improve HIV viral suppression for patients with substance use disorders

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


ADMINISTERING_IC: TW

ED_INST_TYPE: SCHOOLS OF PHARMACY

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: FOGARTY INTERNATIONAL CENTER

ORG_CITY: AMHERST

ORG_DEPT: PHARMACOLOGY

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

ORG_STATE: NY

PHR: This HIV Research Training renewal application will focus on HIV Clinical Pharmacology and Therapeutics research to improve public health and build on the progress that has been made to attain a core group of externally funded HIV researchers who will contribute to meeting 95-95-95 and ending the HIV epidemic.

PI_NAMEs: MAPONGA, CHARLES ENOS CHIEDZA;MORSE, GENE D. (contact)

PROGRAM_OFFICER_NAME: BANSAL, GEETHA PARTHASARATHY

PROJECT_TERMS: Address;Advisory Committees;AIDS prevention;Anti-Retroviral Agents;biomedical informatics;Clinical Pharmacology;Clinical Research;Collaborations;Communities;comorbidity;COVID-19;Data Science;Development;Drug Kinetics;Educational Curriculum;Epidemic;Fogarty International Center;Formulation;Fostering;Foundations;Funding;Genomics;Goals;HIV;HIV-1;innovation;Knowledge;Lamivudine;low and middle-income countries;Mentors;microbiome;Monoclonal Antibodies;neutralizing antibody;novel;novel therapeutics;Pharmacodynamics;Pharmacologic Substance;Postdoctoral Fellow;pre-doctoral;prevent;Prevention strategy;Productivity;programs;public health priorities;public-private partnership;Qualifying;Research;Research Design;Research Personnel;Research Project Grants;Research Training;Safety;Science;Scientist;skills;Supervision;Support Groups;Tenofovir;Therapeutic;Therapeutic Agents;Therapeutic Research;Traditional Medicine;Training;Training and Education;Training Programs;Translational Research;translational scientist;transmission process;treatment as prevention;Universities;Viral Load result;Zimbabwe

PROJECT_TITLE: HIV Clinical Pharmacology & Therapeutics Research Training Program


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Infertility;Pediatric

ORG_CITY: IOWA CITY

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Project Narrative SLC9 family of membrane transporters play key roles in pH and salt homeostasis in all living cells and genetic mutations in these proteins have been linked to a variety of pathological conditions such as epilepsies, autism, digestive disorders, male infertility, etc. In this proposal we will determine high resolution structures and investigate functional mechanisms of a unique SLC9 family member, SLC9C1. This will advance our understanding of how this protein is regulated by physical and chemical stimuli and guide developments of new intervention strategies to treat pathophysiological conditions arising from disfunction of these proteins.

PI_NAMEs: CHOWDHURY, SANDIPAN  (contact)

PROGRAM_OFFICER_NAME: NIE, ZHONGZHEN

PROJECT_TERMS: Action Potentials;Activities of Daily Living;Address;Affect;Angelman Syndrome;Architecture;Attention deficit hyperactivity disorder;autism spectrum disorder;Binding;Biochemical;Biological Assay;Biophysical Process;C-terminal;Cardiac;Cations;CCL21 gene;Cell Proliferation;Cells;Charge;Chemicals;Choline;Couples;Cryoelectron Microscopy;Cues;Cyclic AMP;Cyclic GMP;Cyclic Nucleotides;Cytoplasm;Cytoplasmic Tail;Data;density;Dependence;design;Detergents;Development;Diabetes Mellitus;Digestive System Disorders;dimer;Disease;DNA Sequence Alteration;Drug Design;electric field;Electrophysiology (science);Endosomes;Enzymes;Epilepsy;Exhibits;experimental study;Family;Family member;Fluorescence;Foundations;Functional disorder;Health;Heart failure;Homeostasis;Human;Hydrogen;Hypertension;innovation;insight;interfacial;Intervention;Investigation;Ion Channel Gating;Ion Exchange;Ion Transport;Ions;Length;Ligands;Link;Liposomes;Male Infertility;Malignant Neoplasms;Maps;Measures;Mediating;member;Membrane;Membrane Proteins;Membrane Transport Proteins;Methods;Micelles;Modeling;Molecular;Molecular Conformation;Movement;Mus;Muscular Dystrophies;mutant;novel;Orthologous Gene;particle;Pathologic;Peptide Hydrolases;pharmacologic;Phosphoric Monoester Hydrolases;Photobleaching;Physiological Processes;Play;Point Mutation;polypeptide;Protein Family;Proteins;Protons;reconstitution;reconstruction;Regulation;Reperfusion Injury;Resolution;Role;Sea Urchins;single molecule;Sodium;Sodium Chloride;sodium ion;Sperm Capacitation;sperm cell;Sperm Motility;Stimulus;Structure;System;Techniques;Testing;therapy design;Thermodynamics;Transmembrane Transport;Variant;voltage

PROJECT_TITLE: Mechanisms of voltage regulation of membrane transport

STUDY_SECTION: BBM

STUDY_SECTION_NAME: Biochemistry and Biophysics of Membranes Study Section[BBM]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Social Determinants of Health

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: The proportion of the US population aged 65 years and older and the number of aged minorities is increasing rapidly; with this demographic shift, significant racial/ethnic disparities remain in age-related conditions such as cognitive impairment, Alzheimer’s Disease, physical disability, and frailty. There is a great need to ensure that the research workforce in aging is representative of the US population. The Hopkins USTAR will provide mentored research experiences, research education, and career development skills in MSTEM areas related to research in aging for underrepresented undergraduates who are interested in research careers in health disparities and minority aging as it relates to age-related diseases.

PI_NAMEs: REBOK, GEORGE W.;THORPE, ROLAND J. (contact)

PROGRAM_OFFICER_NAME: TORRES, DELANY

PROJECT_TERMS: Address;Adult;age related;age-related disease;aged;Aging;aging related;aging related disease;Alzheimer's Disease;Alzheimer's disease related dementia;Area;Baltimore;Behavior;Behavioral;Behavioral Sciences;Biological;Biomedical Research;Biometry;career;career development;Career Mobility;Censuses;Color;County;Demographic Transitions;design;Development;Discipline;Discipline of Nursing;Disparity;Education;education research;Educational Curriculum;Ensure;Environment;Epidemiology;ethnic disparity;ethnic diversity;ethnic minority population;Ethnic Population;Evaluation;experience;Exposure to;Faculty;frailty;Funding;Goals;graduate school;Grant;Health;health determinants;Health Disparities Research;health disparity;health equity;health management;Health Policy;healthcare community;human old age (65+);Impaired cognition;Individual;Infrastructure;Institution;Interdisciplinary Study;interest;Knowledge;late life;Leadership;leadership development;Life Cycle Stages;marginalization;Maryland;medical schools;Medicine;Mental Health;Mentors;Mentorship;Minority;minority health;Nature;older adult;Outcome;Pathway interactions;physical conditioning;Physical Function;physically handicapped;Policies;Population;Process;Program Description;programs;Public Health;Public Health Schools;racial disparity;racial diversity;racial minority population;racial population;Reduce health disparities;Reporting;Research;Research Personnel;Research Project Grants;Resource Development;School Nursing;science, technology, engineering, mathematics, and medicine;skill acquisition;social culture;Societies;STEM field;student participation;Training;Training Programs;Training Support;Translating;undergraduate research;undergraduate student;underrepresented minority student;Underrepresented Populations;United States;Universities

PROJECT_TITLE: The Hopkins Undergraduate Summer Training and Research (USTAR) Program


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Adolescent Sexual Activity;Behavioral and Social Science;Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Prevention;Social Determinants of Health

ORG_DEPT: MISCELLANEOUS

PHR: Project Narrative This project will generate evidence on the process of empowerment and its effects on sexual and reproductive health behaviors for boys and girls as they transition from very young adolescence to young adulthood. Programs to encourage empowered decision-making can have a significant impact during this critical developmental time-period, leading to improved life- long outcomes, but there is currently little research conducted on empowerment in this age group. Project results can directly inform interventions that increasingly aim to empower girls, engage with boys, and address harmful gender norms.

PI_NAMEs: ZIMMERMAN, LINNEA ARIEL (contact)

PROGRAM_OFFICER_NAME: POPKIN, RONNA

PROJECT_TERMS: Acceleration;Address;Adolescence;Adolescent;Adolescent Development;adolescent health;Adult women;Affect;Age;age group;aged;Agreement;Behavior;behavior influence;boys;Cohort Studies;Contraception Behavior;Cox Proportional Hazards Models;Data;Data Analyses;Decision Making;Democratic Republic of the Congo;Development;Developmental Process;Dimensions;Economics;empowerment;Enrollment;Family;Freedom;Gender;gender disparity;Gender Role;girls;Goals;Growth;Health;Health behavior;Health behavior and outcomes;Health Knowledge Attitudes Practice;Household;improved;Individual;innovation;instrument;Intervention;Learning;lens;Link;Logistic Regressions;longitudinal analysis;Male Adolescents;Measures;Modeling;Morbidity - disease rate;mortality;Movement;Neighborhoods;novel;Outcome;Parents;Patriarchies;peer;Perception;Population;Process;Program Development;programs;Puberty;reproductive;Reproductive Health;Research;Resources;Risk;Running;Sampling;Schools;sex;Sex Behavior;sexual and reproductive health;sexual debut;Sexual Development;sexual violence;Sexually Transmitted Diseases;Socialization;Societies;Structure;therapy design;therapy development;Time;transition to adulthood;unintended pregnancy;Voice;young adult

PROJECT_TITLE: Understanding developmental trajectories among early adolescents to improve reproductive health

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Population Sciences Study Section[CHHD-W]


ADMINISTERING_IC: EB

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_CITY: SAN FRANCISCO

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE Hyperpolarized MR is an emerging molecular imaging method to monitor enzymatic conversions through key, previously-inaccessible biochemical pathways. In this renewal project, this center aims to collaboratively develop new technology with broad geographic and scientific diversity to advance this field in order to better identify and understand human disease and to translate and disseminate these techniques for new clinical trials and ultimately improved patient care.

PI_NAMEs: VIGNERON, DANIEL B (contact)

PROGRAM_OFFICER_NAME: BARRY, ROBERT LEO II

PROJECT_TERMS: 2,4-Dinitrophenol;Address;Advisory Committees;Algorithms;Biochemical Pathway;Bioreactors;Chemistry;Clinical;Clinical Research;clinical translation;Clinical Trials;Communication;Communities;Computer software;Data;Data Analyses;data infrastructure;data management;design;detector;Development;Documentation;Educational workshop;Environment;Extramural Activities;Funding;Future;Geography;Goals;Growth and Development function;Human;human disease;human subject;imaging modality;imaging probe;imaging study;improved;Industry;Infrastructure;instrumentation;interest;Leadership;Magnetic Resonance Imaging;metabolic imaging;Methodology;Methods;Molecular;molecular imaging;Monitor;Multimodal Imaging;new technology;Newsletter;novel;open source;Pathologic;Patient Care;Physician Executives;Physicians;pre-clinical;Pre-Clinical Model;pre-clinical research;radiologist;reconstruction;Reporting;Research;Research Personnel;research study;Resolution;Resources;Science;Scientist;Services;Site;skills;social media;Software Tools;Structure;symposium;synergism;Techniques;Technology;technology development;technology research and development;Testing;Time;Training;Training Programs;Translating;Translations;Validation;virtual;Visualization;Visualization software;web site

PROJECT_TITLE: Hyperpolarized MRI Technology Resource Center


PROJECT_TERMS: Acceleration;Address;Advisory Committees;Clinical;Clinical Research;clinical translation;Communities;Computer software;Decision Making;design;Development;Educational workshop;Environment;Event;experience;Extramural Activities;Feedback;Funding;Geography;Goals;human subject;improved;Industry;Infrastructure;Institution;instrumentation;International;Leadership;Magnetic Resonance Imaging;member;Minnesota;National Institute of Biomedical Imaging and Bioengineering;new technology;Newsletter;organizational structure;pre-clinical research;Procedures;Productivity;programs;Publications;radiologist;Reporting;Research;Research Personnel;Resources;Services;Site;skills;Source;Structure;symposium;synergism;Techniques;Technology;technology development;tool;Training;Training Activity;Training Support;Translations;Universities;web site


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Neurosciences;Social Determinants of Health

ORG_CITY: PHILADELPHIA

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PI_NAMEs: PLATT, MICHAEL L (contact)

PROGRAM_OFFICER_NAME: BREEDEN, ANDREW LEE

PROJECT_TERMS: Aggressive behavior;Ally;Animals;Anterior;Area;Argipressin;Attention;autism spectrum disorder;Automation;Behavior;Behavioral;Biological;Brain;Brain imaging;Chiroptera;cingulate cortex;Cognitive;Collaborations;Communication;Computer Vision Systems;Computers;contagion;Cortical Synchronization;Coupled;Coupling;Data;Data Science;Direct Costs;Disease;Dorsal;drinking;Drug Delivery Systems;Eating;Economics;electrical microstimulation;Emotional;Emotions;Empathy;Ethology;Evaluation;evidence base;experimental study;Facial Expression;Faculty;Feedback;feeding;Female;fighting;frontal lobe;Future;Game Theory;Gestures;Goals;Grant;Grooming;Health;Heart Rate;Homologous Gene;Human;human-in-the-loop;imaging study;Impairment;Implant;improved;indexing;Individual;Infusion procedures;innovation;Investments;Knowledge;Laboratories;Learning;Link;Macaca;male;Mathematics;Medial;Mediating;Memory;mentalization;Methods;microstimulation;Modeling;Monkeys;Motivation;multi-electrode arrays;neural;neural circuit;Neurons;neurophysiology;neurotransmission;Noise;Oxytocin;Peptides;Perception;Peripheral;Personal Satisfaction;pharmacologic;Pharmacology;Physiological Processes;Primates;Process;Publishing;Research;Resources;restraint;Same-sex;Schizophrenia;Schools;sex;Shapes;Signal Transduction;social;social attention;Social Behavior;social cognition;Social Development;Social Environment;Social Functioning;social group;Social Interaction;social neuroscience;social relationships;Structure of superior temporal sulcus;success;System;Techniques;Technology;Testing;Translating;Trust;Update;wireless;Work

PROJECT_TITLE: Neural Circuit Mechanisms Mediating TMS and Oxytocin Effects on Social Cognition

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


PROJECT_TERMS: 2,4-Dinitrophenol;Abdomen;Advisory Committees;Animal Model;Animals;Attention;Automobile Driving;Brain;Brain Diseases;Clinical;Clinical Research;clinical translation;Communities;cost;Data;design;detector;Development;Documentation;Educational workshop;Engineering;Environment;ergonomics;Extramural Activities;Feedback;Funding;Future;Guidelines;Heart Diseases;Human;human data;human subject;improved;in vivo;Industry;Industry Collaboration;innovation;Institution;instrument;instrumentation;interest;International;Leadership;Liquid substance;Liver diseases;Magnetic Resonance Imaging;Malignant Neoplasms;manufacture;manufacturing facility;metabolic imaging;Methods;molecular imaging;new technology;next generation;novel;patient oriented;Patients;Performance;perfusion imaging;Pharmacists;Pharmacy facility;pre-clinical;preclinical study;radiologist;rapid technique;reconstruction;Reporting;Research Personnel;Resources;RF coil;S10 grant;Sampling;Site;skills;SP1 gene;Speed;Sterility;System;Technology;technology development;technology research and development;Test Result;Testing;Tissues;Training;Training Activity;Translations;transmission process;United States National Institutes of Health;Vendor;Visualization;web site

PROJECT_TITLE: Technology Development for Polarizer and Detector Instrumentation


ADMINISTERING_IC: CA

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics;Orphan Drug;Ovarian Cancer;Rare Diseases;Women's Health Research

ORG_CITY: BOSTON

ORG_NAME: APREA THERAPEUTICS, INC.

ORG_STATE: MA

PHR: PROJECT NARRATIVE High-grade serous ovarian carcinoma (HGSOC) is a devastating disease that critically needs more efficacious treatments. Atrin Pharmaceuticals, Inc is developing a first-in-class combination of novel DNA damage response inhibitors for the treatment of HGSOC.

PI_NAMEs: BROWN, ERIC J;GILAD, OREN  (contact);SIMPKINS, FIONA

PROGRAM_OFFICER_NAME: FRANCA-KOH, JONATHAN C

PROJECT_TERMS: 12 year old;attractin protein;Biological Availability;Biological Markers;Body Weight decreased;brca gene;BRCA mutations;BRCA1 gene;BRCA2 gene;Cancer cell line;candidate marker;Canis familiaris;CCNE1 gene;Cell Line;Cell model;cell type;Cells;Cessation of life;Chemistry;chemotherapy;Clinical;clinical development;clinical trial protocol;Combined Modality Therapy;Data;Defect;Development;Disease;DNA Damage;DNA replication fork;DNA Sequence Alteration;Dose;Drug Kinetics;efficacious treatment;Exhibits;Failure;first-in-human;Gene Expression;Genetic Transcription;Genomics;Germ Lines;Growth;Half-Life;homologous recombination;Human;inhibitor;kinase inhibitor;Libraries;Malignant neoplasm of ovary;manufacture;Medicine;Modeling;Molecular;Molecular Profiling;Mus;mutant;next generation;novel;Oral;Ovarian Serous Adenocarcinoma;overexpression;patient derived xenograft model;patient population;Patients;Pennsylvania;Pharmacologic Substance;Pharmacology;Phase;Phosphotransferases;Platinum;PLK1 gene;Poly(ADP-ribose) Polymerase Inhibitor;predicting response;predictive marker;Proteomics;Publishing;Rattus;Recommendation;recruit;repaired;Reporting;Resistance;responders and non-responders;response;Safety;Serous;Signal Transduction;Specificity;success;Survival Rate;Testing;Therapeutic Index;Toxic effect;Toxicology;Treatment-related toxicity;tumor;tumor growth;tumor xenograft;Universities;Woman

PROJECT_TITLE: Development of a first-in-class combination of DNA damage response inhibitors for the treatment of high-grade serous ovarian cancer


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Prevention;Prostate Cancer;Radiation Oncology;Urologic Diseases

ORG_CITY: MILWAUKEE

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

PHR: Project Narrative This project will provide a detailed understanding of how prostate tumors at the cellular level appear on macroscopic imaging by examining post-surgical prostate tissue samples aligned with clinical MRI scans. We will develop computational algorithms that recognize patterns in MRI scans (i.e. radio-pathomics), which can then be applied to patients to more fully understand the status of prostate tumors prior to surgery and during treatment. We expect that clinical decision-making will improve dramatically as a complete picture of pathomic features underlying prostate cancer with high metastatic potential emerges from this proposal.

PI_NAMEs: LAVIOLETTE, PETER S (contact)

PROGRAM_OFFICER_NAME: DARDZINSKI, BERNARD JOSEPH

PROJECT_TERMS: Affect;Algorithms;Architecture;Biological Markers;cancer risk;Clinic;Clinical;clinical application;clinical decision-making;clinical imaging;clinically significant;Computational algorithm;Computer software;Consensus;Data Set;Dependence;Diagnosis;Diagnostic;Differential Diagnosis;Disease;disorder risk;Early Diagnosis;evidence base;Exhibits;experimental study;External Beam Radiation Therapy;Funding Opportunities;Gland;Gleason Grade for Prostate Cancer;Goals;high risk;Histologic;Histology;Image;image processing;imaging biomarker;Imaging Device;imaging system;improved;Individual;individualized medicine;Indolent;Libraries;Location;Magnetic Resonance Imaging;Malignant neoplasm of prostate;Malignant Neoplasms;Maps;Measures;men;Methods;Microscopic;Modeling;MRI Scans;non-invasive imaging;Operative Surgical Procedures;overtreatment;Pathology;Patients;Pattern Recognition;Performance;personalized cancer therapy;Physicians;Population;predictive modeling;Prognosis;Prostate;prostate cancer risk;Prostate Cancer therapy;Prostatic Neoplasms;Protocols documentation;quantitative imaging;Radiation;Radiation therapy;Radical Prostatectomy;Radio;Radiology Specialty;Recurrence;Recurrent tumor;resilience;response;Risk;Sampling;screening;Sensitivity and Specificity;serial imaging;Severity of illness;Stress Tests;System;Techniques;Technology;Testing;Therapeutic;Tissue Sample;tool;training data;Translating;treatment strategy;tumor;Validation;Vendor

PROJECT_TITLE: Prostate Cancer Radio-Pathomics for Differentiating Clinically Significant Disease


PI_NAMEs: KURHANEWICZ, JOHN  (contact)

PROJECT_TERMS: 2,4-Dinitrophenol;Address;Advisory Committees;Bicarbonates;Biochemical;Biological;Biological Markers;Bioreactors;cancer site;Cell Culture Techniques;Chemicals;Chemistry;Citric Acid Cycle;Clinical;clinical application;Clinical Research;clinical translation;clinically relevant;cold temperature;Communities;Consumption;Coupled;Data;Data Analyses;Data Display;Deuterium;Development;Disease Progression;driving force;Engineering;Enzymes;experience;Formulation;Funding;Generations;Genetically Engineered Mouse;Goals;Grant;Image;image translation;imaging approach;imaging probe;imaging study;Imaging Techniques;improved;in vivo;innovation;Investigation;Label;Leadership;Magnetic Resonance Imaging;Measurement;Metabolic;metabolic imaging;metabolomics;Methodology;Methods;Modeling;Molecular;molecular imaging;multidisciplinary;Multimodal Imaging;Neoplasm Metastasis;next generation;novel;novel strategies;Nutrient;open source;Oxygen;Pathologic;Pathology;patient derived xenograft model;Patients;Peer Review;Performance;perfusion imaging;Physiologic pulse;Positron-Emission Tomography;pre-clinical;Pre-Clinical Model;Preparation;Procedures;Productivity;program dissemination;Protocols documentation;Publications;Pyruvate;Qualifying;quantitative imaging;radiologist;Research;Research Personnel;Resources;RF coil;Sample Size;Science;Services;Signal Transduction;Standardization;success;synergism;System;Techniques;Technology;Testing;tissue culture;tissue/cell culture;tool;Training;transcriptomics;treatment response;United States National Institutes of Health;Urea;Validation;validation studies

PROJECT_TITLE: Development of Novel Hyperpolarized MR Molecular Imaging Probes Tested in Realistic Pre-Clinical Models and Correlative Science Studies


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Social Determinants of Health

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: Project Narrative This project aims to examine the influence of contextual-level neighborhood characteristics and person-specific neighborhood experiences on trajectories of cognitive aging and Alzheimer’s disease and related dementias. The study will also examine neighborhood factors influencing cognitive health disparities. The expected outcomes will guide sustainable behavioral interventions and population-level interventions to promote cognitive health especially among vulnerable populations.

PI_NAMEs: HYUN, JINSHIL  (contact)

PROJECT_TERMS: Address;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Amyloid;apolipoprotein E-4;Area;Automobile Driving;Award;Behavior Therapy;Behavioral;Biological Markers;biological sex;Biometry;Blood Vessels;brain health;career;Cellular Phone;Characteristics;Cognition;Cognitive;Cognitive aging;cognitive function;cognitive performance;cognitive testing;college;Data;Data Analyses;Data Collection;Data Set;Dementia;Development;Disparity;Ecological momentary assessment;Environment;experience;Exposure to;Five-Year Plans;follow-up;Foundations;Genetic;Geographic Information Systems;Health;health disparity;Hour;Impaired cognition;Individual;Intervention;late life;Magnetic Resonance Imaging;Measures;Medicine;Mentors;Mentorship;Methods;mild cognitive impairment;multidisciplinary;Neighborhoods;Nerve Degeneration;Neuroepidemiology;Neuropsychological Tests;Neuropsychology;older adult;Outcome;Outcomes Research;Participant;Pathology;Pathway interactions;Pattern;Perception;Persons;Phase;Population;Process;protective factors;Qualifying;Race;Research;Resources;Risk;Risk Factors;Scientist;social;spatiotemporal;Subgroup;tau Proteins;Training;Urban Health;Variant;Vulnerable Populations;White Matter Hyperintensity

PROJECT_TITLE: Neighborhood characteristics, GPS-based activity space, and cognitive health

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development Facilitating The Transition to Independence Study Section[AGCD-1]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

PI_NAMEs: XU, DUAN  (contact)

PROJECT_TERMS: Address;archive data;Archives;Atlases;Behavior;Blood Vessels;Bolus Infusion;Calibration;Clinical Data;clinical imaging;Collaborations;Communities;Computer software;Data;data acquisition;Data Analyses;data archive;data format;data harmonization;data infrastructure;data management;data portal;data quality;Data Set;data sharing;denoising;Development;digital;Digital Imaging and Communications in Medicine;Ensure;Evaluation;experimental study;flexibility;Frequencies;Funding;Geometry;Goals;Heterogeneity;Human Volunteers;Image;image reconstruction;improved;in vivo;Infrastructure;innovation;kinetic model;Kinetics;large datasets;large scale data;Machine Learning;machine learning method;Magnetic Resonance Imaging;Metabolism;Metadata;Methodology;Methods;Modeling;Molecular;Monte Carlo Method;next generation;novel;open source;Patients;Perfusion;Physiologic pulse;pre-clinical;preclinical imaging;Protocols documentation;Quality Control;reconstruction;Resolution;Resources;Scanning;Scheme;Services;Signal Transduction;Site;Software Framework;SP1 gene;Spatial Distribution;spatiotemporal;Standardization;System;Techniques;Technology;Time;tool;Training;training data;Update;Vendor;Visualization;web site

PROJECT_TITLE: Acquisition and Analysis Methods for Hyperpolarized MR Data


PROJECT_TERMS: 2,4-Dinitrophenol;Area;biomedical imaging;Bioreactors;Carbon;Cell Culture Techniques;Chemistry;Client;Clinical;Clinical Research;clinical translation;Collaborations;Communication;Communities;Computer software;Data;design;Development;Doctor of Philosophy;doctoral student;Documentation;Dose;driving force;Educational workshop;Electronic Mail;Environment;Equipment;Event;experience;Extramural Activities;Faculty;Feedback;Funding;Generations;Geography;Goals;Growth and Development function;Human;Human Resources;human subject;imaging approach;imaging modality;Imaging Techniques;improved;Individual;Industry;Institution;instrumentation;interest;International;lectures;Magnetic Resonance Imaging;Mentors;Methods;molecular imaging;new technology;Newsletter;novel;online resource;outreach;Paper;Pharmacy facility;Physiologic pulse;Postdoctoral Fellow;pre-clinical;Pre-Clinical Model;pre-clinical research;Preparation;Production;program dissemination;programs;Protocols documentation;Publications;radiological imaging;Radiology Specialty;Recipe;reconstruction;Reporting;Research;Research Personnel;research study;Resources;sabbatical;Sampling;Services;Site;skills;social media;software development;Source;Sterility;Surveys;synergism;Techniques;Technology;technology development;technology research and development;Test Result;tissue culture;tool;Training;Training Activity;training opportunity;Training Programs;Translational Research;Translations;Update;virtual;Visit;web site


ADMINISTERING_IC: EY

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision

ORG_CITY: ATLANTA

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: The future of curing blinding eye disease relies on a continued supply of well-trained vision scientists. Our goal is to produce the next generation of scientists who are well versed in basic, clinical, and translational research approaches that will be needed to fulfill the future missions of the National Eye Institute.

PI_NAMEs: PARDUE, MACHELLE T. (contact)

PROGRAM_OFFICER_NAME: CLAYTON, EDWIN C

PROJECT_TITLE: Multidisciplinary Training in Vision and Research


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Hematology;Neurosciences;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: PROJECT NARRATIVE Hematopoietic stem cell (HSC) transplantation is a potential cure for several malignant and non-malignant blood disorders. However, delayed/impaired hematopoietic reconstitution due to myeloablative conditioning induced bone marrow damage, and limited availability of donor HSC often causes fatal complications. This project seeks to understand how myeloablative stress-induced alternation of NPY signals in the bone marrow contributes to hematopoietic defects after transplantation, and whether modulating NPY signaling can improve HSC transplantation efficacy.

PI_NAMEs: SINGH, PRATIBHA  (contact)

PROGRAM_OFFICER_NAME: BAI, C BRIAN

PROJECT_TERMS: Acceleration;acquired bone marrow failure;Acute;adaptive immunity;Adrenergic Agents;alpha-Thalassemia;Applications Grants;Blood;Blood Vessels;Bone Marrow;bone marrow failure syndrome;Cell Count;Cell surface;Cells;chemoradiation;chemotherapy;Chemotherapy and/or radiation;Chronic;Circulation;Collecting Cell;Complication;conditioning;CSF3 gene;CXCR4 gene;cytotoxic;Data;Defect;Dipeptidyl-Peptidase IV;DNA Damage;Dose;Endogenous Factors;Endothelial Cells;Engraftment;exposed human population;Functional disorder;Generations;genetic manipulation;genotoxicity;Hematologic Neoplasms;Hematological Disease;Hematopoiesis;Hematopoietic;hematopoietic engraftment;hematopoietic stem cell niche;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;hematopoietic transplantation;Homeostasis;Homing;Human;Immune;Impairment;improved;Inherited;Ionizing radiation;irradiation;Knockout Mice;Maintenance;Malignant - descriptor;Mediating;mesenchymal stromal cell;Metabolic Diseases;migration;Modeling;Molecular;Mus;Natural regeneration;Neurons;Neuropathy;neuropeptide Y;Neuropeptide Y Receptor;neuroprotection;neurotransmission;Neurotransmitters;Neutropenia;Non-Malignant;novel therapeutic intervention;Opportunistic Infections;Outcome;Oxidative Stress;Pathologic;Patients;Peptidyl-Dipeptidase A;Peripheral Nervous System Diseases;pharmacologic;Physiological;Play;Population;preconditioning;Premature aging syndrome;Prevention approach;Production;Radiation;Reactive Oxygen Species;reconstitution;Recovery;Regimen;Regulation;repaired;Reporting;response;restoration;Risk;Role;senescence;Signal Transduction;stem cell expansion;stem cell function;stem cell homeostasis;stem cell niche;stem cell survival;Stem cell transplant;Stress;Supplementation;System;Testing;Therapeutic;therapeutic target;transplant model;Transplantation;Whole-Body Irradiation;Wild Type Mouse;Work

PROJECT_TITLE: The role of NPY in stress-induced hematopoiesis

STUDY_SECTION: BBHV

STUDY_SECTION_NAME: Basic Biology of Blood, Heart and Vasculature Study Section [BBHV]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Aphasia;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Neurosciences

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative: This study aims to explore some of the fundamental cellular mechanisms that underlie human language using advanced micro-electrode recording, neurophysiologic and computational techniques. Studying these processes is essential to many contemporary theories in neurolinguistics and will provide an important new framework for investigating higher-cognitive processes in humans. This proposed research has the potential to advance not only our understanding of core linguistic processes at the basic cellular level, but also our understanding of how language may be impaired in disorders such as dyslexia, aphasia or autism spectrum disorder.

PI_NAMEs: WILLIAMS, ZIV  (contact)

PROGRAM_OFFICER_NAME: STORKEL, HOLLY LYNN

PROJECT_TERMS: Action Potentials;Algorithms;Animal Model;Animals;Aphasia;Area;autism spectrum disorder;Brain;Cells;Chronic;Cognition;cognitive process;combinatorial;Communication;Communication impairment;Communities;Complex;Computational Technique;Computer Models;Data;Dependence;Derivation procedure;Disease;Dyslexia;Electrodes;FDA approved;frontal lobe;Goals;Grain;Higher Order Chromatin Structure;Human;Impairment;Implant;Individual;insight;Institution;Institutional Review Boards;Language;language comprehension;Language Disorders;Left;Letters;Linguistics;Maps;Microelectrodes;Modeling;neural;Neurons;neurophysiology;novel;Participant;Population;Prefrontal Cortex;Process;prospective;Psychological Techniques;Research;Resolution;response;semantic processing;Semantics;Speech;Speech Sound;Structure;syntax;Techniques;Temporal Lobe;temporal measurement;Testing;theories;Time;Tissues;Validation

PROJECT_TITLE: Studying semantic processing during language comprehension in humans at the single-cellular level

STUDY_SECTION: LCOM

STUDY_SECTION_NAME: Language and Communication Study Section[LCOM]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because the identification of factors determining outcomes in childhood epilepsies is ultimately expected to translate into necessary improvements to care for this medically vulnerable population. Thus, the proposed research is relevant to the purpose of the NIH to acquire new knowledge to help prevent, detect, diagnose, and treat disease and disability, enhance the lives of children and adolescents, and optimize abilities for all.

PI_NAMEs: HELBIG, INGO  (contact)

PROGRAM_OFFICER_NAME: WHITTEMORE, VICKY R

PROJECT_TERMS: Address;Adolescent;Anticonvulsants;Brain Diseases;Caring;Case Series;Case Study;Child;childhood epilepsy;Chorea;Classification;Clinical;clinical care;Clinical Data;cohort;Complement;Complex;Consumption;Data;de novo mutation;Development;developmental disease;Diagnosis;Dictionary;disability;Disease;early onset;Epilepsy;Etiology;exome;Future;gain of function;Genes;Genetic;Genetic Predisposition to Disease;genetic variant;genomic variation;Genomics;Genotype;Goals;Human;improved;Independent Scientist Award;Individual;Infantile spasms;Inherited;insight;Intractable Epilepsy;Knowledge;Life;Link;loss of function;Manuals;medical vulnerability;Methods;mouse model;Natural History;Neurodevelopmental Disorder;neurogenetics;novel strategies;Ontology;Other Genetics;Outcome;Parents;Patients;Pattern;Phenotype;Positioning Attribute;precision medicine;prevent;Prognosis;Public Health;rare variant;Recurrence;Research;response;Risk;Risk Assessment;SCN8A gene;Seizures;Semantics;Sodium Channel Blockers;stem cell model;Subgroup;Time;tool;Translating;treatment response;trial design;United States National Institutes of Health;Variant;Vulnerable Populations;Work

PROJECT_TITLE: A computational phenotyping approach to characterize neurogenetic disorders

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Diabetes;Nutrition;Obesity

ORG_CITY: STANFORD

ORG_DEPT: PATHOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: There is a tremendous need for the discovery of new pathways of energy metabolism to address the growing burden of obesity and type 2 diabetes. This project is relevant to public health because our work may lead to therapeutics that reduce the burden of obesity and type 2 diabetes in people’s health and improve their quality of life. This proposal will uncover the regulation and function of a new bioactive lipid pathway that regulates energy expenditure.

PI_NAMEs: LONG, JONATHAN Z (contact)

PROGRAM_OFFICER_NAME: LYNCH, CHRISTOPHER

PROJECT_TERMS: Ablation;Address;Amino Acids;analog;Binding;Binding Proteins;Biochemistry;Biology;blood glucose regulation;chemical synthesis;Chemicals;combat;crosslink;Data;Diabetes Mellitus;diet-induced obesity;Disease;Drug Kinetics;Energy Metabolism;Energy Metabolism Pathway;enzyme activity;Enzymes;Evaluation;Exhibits;experimental study;extracellular;Extracellular Protein;Family;Family member;Fatty Acids;Future;Genetic;Glucose Intolerance;Goals;Health;Homeostasis;Hydrolase;improved;Inner mitochondrial membrane;Insulin Resistance;Leucine;Ligands;Lipids;Mediating;Medical;member;Metabolic Diseases;metabolomics;Mitochondria;Molecular;mouse model;Mus;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;Obesity associated disease;Obesity Epidemic;obesity treatment;Outcome;Pathway interactions;Peptide Hydrolases;Persons;pharmacologic;Phenotype;Phenylalanine;Potential Energy;Property;Protons;Public Health;Quality of life;Regulation;Respiration;Testing;Therapeutic;Work

PROJECT_TITLE: Chemical control of energy metabolism by N-acyl amino acids

STUDY_SECTION: INMP

STUDY_SECTION_NAME: Integrative Nutrition and Metabolic Processes Study Section[INMP]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Comparative Effectiveness Research;Health Services;Patient Safety;Physical Injury - Accidents and Adverse Effects;Prevention;Substance Misuse;Tobacco;Tobacco Smoke and Health

PHR: PROJECT NARRATIVE The proposed randomized clinical trial will examine the effectiveness of a smoking cessation intervention and a short-term patient incentive strategy in reducing smoking associated major complications in the orthopedic trauma population. This approach will answer key questions to build evidence on the design and implementation of future smoking cessations programs.

PI_NAMEs: CASTILLO, RENAN C (contact)

PROGRAM_OFFICER_NAME: WASHABAUGH, CHARLES H

PROJECT_TERMS: Adoption;Architecture;Clinical;Collaborations;Complication;Consensus;cost;cost effective;Counseling;Coupled;critical period;Data;data standards;Day Surgery;design;Disabling;Dose;Effectiveness;effectiveness evaluation;Enrollment;experience;follow-up;functional outcomes;future implementation;Goals;hospital readmission;Hospitals;improved;incentive strategies;Incentives;Infection;Infrastructure;injured;Injury;inpatient service;Inpatients;Intervention;limb injury;Limb structure;Link;Literature;Long term disability;Lower Extremity;Measurement;Measures;motivational enhancement therapy;novel;Orthopedics;Outcome;Outcome Study;Patient Outcomes Assessments;Patient Self-Report;Patient-Focused Outcomes;Patients;payment;Population;primary outcome;programs;Public Health Schools;Quality of life;Randomized;randomized, clinical trials;Recovery;Reporting;Research;Research Design;response;Risk;Risk Factors;Sampling Studies;satisfaction;scale up;secondary outcome;Smoking;smoking cessation;Smoking Cessation Intervention;soft tissue;standard of care;Standardization;Surgical complication;Surgical Wound Infection;Testing;tobacco cessation intervention;Tobacco use;Tobacco Use Cessation;Trauma;trauma centers;Trauma patient;Trauma Research;Urine;wound

PROJECT_TITLE: Using Patient Incentive Payments to Reduce Smoking Associated Surgical Complications Following Lower Extremity Trauma: A randomized Clinical Trial

STUDY_SECTION: AMSC

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Clinical Trials Study Section [AMSC(10)]


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

PHR: Project narrative Intrinsically photosensitive retinal ganglion cells influence diverse physiological functions and behaviors, ranging from global gene expression to mood. The dysfunction of these pathways has been implicated in many diseases, including metabolic syndrome, severe depression, shift worker syndrome and cancer.

PI_NAMEs: SIVYER, BENJAMIN M (contact)

PROGRAM_OFFICER_NAME: WRIGHT, CHARLES BAKER

PROJECT_TERMS: Anatomy;Antibodies;Area;Axon;Behavior;Body Temperature;Brain;Brain region;cell type;Cells;circadian;Classification;Cluster Analysis;Code;Color;Cone;Confocal Microscopy;Data;Dendrites;density;Detection;Disease;Dorsal;Enzymes;experimental study;Eye;Functional disorder;functional group;Health;Image;Individual;Injections;Label;Laboratories;Light;Location;luminance;Malignant Neoplasms;Maps;Measures;melanopsin;Mental Depression;Messenger RNA;Metabolic syndrome;Moods;Morphology;mosaic;mRNA Expression;multi-electrode arrays;Mus;Mydriasis;Neuropeptides;neurotransmission;neurotransmitter release;Neurotransmitters;novel;Optic Nerve;Output;Pathway interactions;Pattern;Photons;Photoreceptors;Physiological;Physiology;postsynaptic neurons;Process;Property;Proteins;Pupil;reconstruction;Reflex action;response;Retina;Retinal Ganglion Cells;Reverse Transcriptase Polymerase Chain Reaction;Sampling;Signal Transduction;Sleep;Stains;Stimulus;Stratification;Synapses;Syndrome;System;Territoriality;Testing;transcriptome;Transgenic Mice;Vision;Visual;Visual Fields;visual information;visual processing;Visual System;Work

PROJECT_TITLE: Functional subtypes of retinal ganglion cell photoreceptors

STUDY_SECTION: BDE

STUDY_SECTION_NAME: Biology and Development of the Eye Study Section[BDE]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Caregiving Research;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

PHR: PROJECT NARRATIVE This proposal will have unique public health importance because (1) it will increase mentoring of junior clinical investigators interested in conducting patient-oriented research on aging and health disparities/health equity for the rapidly growing elderly population, and (2) it will inform future intervention studies to create and test culturally appropriate tools aimed at identifying and including family caregivers in primary care before older patients experience severe health and functional decline.

PI_NAMEs: KARLINER, LEAH S (contact)

PROGRAM_OFFICER_NAME: GERALD, MELISSA S

PROJECT_TERMS: Age;Aging;aging related disease;Area;Audiotape;breast cancer diagnosis;care delivery;career;Caregivers;caregiving research;Caring;Chinese;Chronic Disease;Chronic Kidney Failure;Clinical;Clinical Investigator;Collaborations;Collection;Communication;Communication Barriers;Communities;comorbidity;Data;Dementia;Discourse analysis;Disease Management;Disparity;Elderly;Ensure;Equity;Ethnic Origin;Evidence based treatment;experience;Family Caregiver;follow-up;functional decline;Funding;Future;Generations;Genetic Transcription;Goals;Guidelines;Health;health care delivery;health care quality;Health Disparities Research;health disparity;health equity;Health Services;Health system;Healthcare;Hospitalization;Hospitals;human old age (65+);improved;interest;International;Internist;Intervention;Intervention Studies;Interview;Knowledge;Language;Latino;Limited English Proficiency;Link;Malignant Neoplasms;Mammography;Medical;Medical Records;Mentors;Mentorship;Mid-Career Clinical Scientist Award (K24);Minority;minority communities;minority investigator;minority patient;Mission;Modification;National Cancer Institute;National Institute of Diabetes and Digestive and Kidney Diseases;National Institute on Aging;next generation;older adult;older patient;Outcome;Participant;Patient Care;patient oriented research;Patient Outcomes Assessments;Patient Preferences;Patient-Focused Outcomes;Patients;Pattern;Perception;Physicians;Population;Population Heterogeneity;Populations at Risk;preference;Primary Care;primary care patient;Primary Care Physician;primary care setting;primary care visit;programs;Public Health;Race;Recommendation;Recording of previous events;Research;Research Personnel;Research Project Grants;Resources;Role;Sampling;Secondary to;skills;Spanish;Structure;success;Surveys;System;Testing;therapy development;tool;Training;Underrepresented Minority;Visit;Woman;Work

PROJECT_TITLE: Mentoring Researchers on Clinical Communication With Diverse Aging Populations

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Clinical Aging Study Section[NIA-C]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Lewy Body Dementia;Neurodegenerative;Neurosciences;Parkinson's Disease

ORG_DEPT: NEUROLOGY

PHR: Project Narrative: Parkinson’s Disease Dementia and Dementia with Lewy Bodies are defined by aggregates of the protein alpha-synuclein. Patients have impairments in functions associated with the prefrontal cortex, such as attention, planning and flexible learning. This proposal will determine how alpha-synuclein pathology affects cortical neurons and activity, providing potential targets to restore cortical function.

PI_NAMEs: ALDRIDGE, GEORGINA  (contact)

PROGRAM_OFFICER_NAME: BABCOCK, DEBRA J

PROJECT_TERMS: Affect;Aging;alpha synuclein;Alzheimer's Disease;Anatomy;Attention;Automobile Driving;Autopsy;Behavior;behavior measurement;Behavioral;Behavioral Paradigm;Behavioral Symptoms;Brain;Brain Stem;cell cortex;Cephalic;Characteristics;Cognitive;cognitive performance;Corpus striatum structure;Cues;Data;Dementia;Dementia with Lewy Bodies;Dendritic Spines;density;Deposition;Disease;Dopamine;Elements;Environment;Etiology;Event;excitatory neuron;Executive Dysfunction;experience;flexibility;frontal lobe;Functional disorder;Future;Genes;Genomics;Goals;Hallucinations;Head;Image;Impaired cognition;Impairment;Implant;in vivo;Individual;insight;Laboratories;Learning;Lewy Body Dementia;Measures;Mediating;Microscopy;motor symptom;Movement;multimodality;Neurobehavioral Manifestations;Neuronal Plasticity;Neurons;Neurotransmitters;nigrostriatal system;Outcome;overexpression;Parkinson Disease;Parkinson's Dementia;Pathologic;Pathology;Patients;Pattern;Performance;postsynaptic;Prefrontal Cortex;protein aggregation;Proteins;psychiatric symptom;Publishing;Research;Risk;Role;Secondary to;Sensory;symptom treatment;Symptoms;Synapses;Synaptic plasticity;System;Testing;Time;Training;two photon microscopy;two-photon;Vertebral column;Viral;Visual Hallucination

PROJECT_TITLE: Cortical Alpha-Synuclein in Dementia

STUDY_SECTION: CDIN

STUDY_SECTION_NAME: Chronic Dysfunction and Integrative Neurodegeneration Study Section[CDIN]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Palliative Care;Racial and Ethnic Minority Health Research

ORG_CITY: DENVER

ORG_NAME: UNIVERSITY OF DENVER (COLORADO SEMINARY)

ORG_STATE: CO

PHR: PROJECT NARRATIVE Attitude toward advance directive (AD) and AD completion are key factors affecting end-of-life (EOL) care among older Americans, especially older Chinese Americans. Although Chinese Americans are one of the largest and fastest growing older minority populations, research aims to understand key factors associated with attitude toward AD and AD completion among this population remains lacking, leaving a critical gap in the minority aging literature and contributing to unsatistfactory EOL care among older Chinese Americans. Therefore, using Andersen’s Health Service Utilization Model and Transtheoretical Model for Behavioral Change, we propose a mixed methods study to evaluate factors associated with older Chinese Americans’ attitude toward AD and AD completion through cross-sectional survey and focus groups.

PI_NAMEs: WANG, KAIPENG  (contact)

PROJECT_TERMS: Acculturation;Address;Advance Care Planning;advanced directive;Affect;Age;aged;Aging;American;Asian Americans;Attitude;Awareness;behavior change;Behavioral Model;Buddhism;Cessation of life;Chinese;Chinese American;Communication;Cross-Sectional Studies;culturally appropriate intervention;Data;Demographic Factors;design;disparity elimination;Elderly;end of life;end of life care;Ensure;Ethnic Population;expectation;Family;Family member;Family Relationship;Focus Groups;Future;Goals;Grant;Health;Health behavior;Health Personnel;Health Professional;health service use;healthcare burden;Hospitals;human old age (65+);Immigrant;improved;Individual;intergenerational;Intervention;Knowledge;Legal;Life;Literature;Medical;Medical Care Costs;Methods;Minority;Minority Groups;Modeling;multiple chronic conditions;older adult;Participant;Patients;Personal Satisfaction;Persons;Play;Population;Positioning Attribute;Predisposing Factor;preference;psychosocial;Quality of Care;Questionnaires;Religion;Religiosity;Research;Role;sex;Shapes;social;social factors;structural determinants;Surveys;Terminal Disease;Theoretical model;United States;Work

PROJECT_TITLE: Examining the relationship between death attitude and AD completion and attitude among older Chinese Americans

STUDY_SECTION: SPIP

STUDY_SECTION_NAME: Social Psychology, Personality and Interpersonal Processes Study Section[SPIP]


NIH_SPENDING_CATS: Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Spinal Cord Injury;Traumatic Head and Spine Injury

PHR: PROJECT NARRATIVE Central nervous system (CNS) injury such as spinal cord injury (SCI) is refractory to repair, attributed to the reduced neuronal intrinsic regeneration capacity and an inhibitory microenvironment largely constituted by the reactive glial cells. Understanding the mechanisms that inhibit or promote neural regeneration is relevant to public health because it may ultimately lead to treatments for neural injury and neurological diseases. Our study demonstrates that reprograming the reactive glial cells via metabolic rewiring promotes CNS axon regeneration and functional recovery, providing a new concept for treating CNS injuries such SCI.

PI_NAMEs: SONG, YUANQUAN  (contact)

PROGRAM_OFFICER_NAME: BAMBRICK, LINDA LOUISE

PROJECT_TERMS: Acute;Adult;Adverse effects;Afferent Neurons;Agonist;Astrocytes;ATP Citrate (pro-S)-Lyase;Axon;axon injury;axon regeneration;Behavioral;Behavioral Assay;Binding;Binding Sites;Biological Assay;Cells;Central Nervous System;central nervous system injury;Chronic;Cicatrix;Citric Acid Cycle;Clinical;Corticospinal Tracts;Coupled;Coupling;Cyclic AMP;Data;data mining;differential expression;Disease;Environment;Enzymes;Evolution;Exhibits;experimental study;fly;Functional Regeneration;Genes;Glycolysis;Goals;Growth;GTP-Binding Proteins;Guanine Nucleotides;Hypertrophy;Impairment;In Situ;Inflammatory;Injections;Injury;insight;Knock-out;Lactate Dehydrogenase;Larva;Mammals;mass spectrometric imaging;Measures;Mediating;Metabolic;Metabolic Pathway;Metabolism;metabolomics;Modeling;Molecular Target;motor disorder;Mus;Mutate;Natural regeneration;neonatal mice;neonate;nerve injury;Nerve Regeneration;Nervous System Disorder;Nervous System Trauma;Neurodegenerative Disorders;Neuroglia;Neurologic Deficit;neuron regeneration;Neurons;novel;overexpression;Paralysed;Pathway interactions;Peripheral;pharmacologic;Phase;Population;prevent;Production;progenitor;Public Health;Publishing;receptor;Receptor Activation;receptor function;Recovery;Recovery of Function;Refractory;regenerative;Regenerative capacity;Regenerative Medicine;regenerative therapy;repaired;Reporting;response;Role;Sensory;Signal Transduction;Site;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;Spinal cord injury;Stem cell transplant;Structure;targeted treatment;Testing;therapeutic target;Tissue Preservation;transdifferentiation;Translating;translational potential;Up-Regulation;Work

PROJECT_TITLE: Glial metabolic status regulates axon regeneration in the central nervous system

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


ORG_CITY: MAYWOOD

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: LOYOLA UNIVERSITY CHICAGO

ORG_STATE: IL

PHR: The proposed program will engage undergraduate and post-baccalaureate trainees in benign urologic disease research at Loyola University Chicago. Trainees will be introduced to research careers in the field, with an emphasis on transdisciplinary and translational approaches. Over 12-week periods, trainee cohorts will: (1) gain exposure to current research in benign urologic disease, (2) establish proficiency conducting hypothesis-driven research, and (3) develop skills to synthesize, interpret, and present scientific research.

PI_NAMEs: PUTONTI, CATHERINE ELIZABETH (contact)

PROGRAM_OFFICER_NAME: MARIC-BILKAN, CHRISTINE

PROJECT_TERMS: Algorithm Design;algorithm training;Area;Award;Bacteria;Benign;Bioinformatics;Biomedical Research;Biometry;Bladder;career;catheter associated UTI;Chicago;Clinical;clinically relevant;cohort;college;Communities;Computerized Medical Record;Culture-independent methods;Data;Data Analyses;Data Science;Data Scientist;Dedications;design;Disease;dysbiosis;Education;Educational process of instructing;Educational workshop;Ethnic Origin;experience;Exposure to;Faculty;Funding;Future;Gender;Genomics;Graduate Education;graduate school;hands on research;Health;Healthcare;Human;improved;Individual;infection risk;Informatics;innovation;Laboratories;Learning;learning strategy;Lower urinary tract;lower urinary tract symptoms;medical schools;meetings;member;men;Mentors;Mentorship;Methods;Microbiology;microbiome research;microbiota;micturition urgency;Mining;National Institute of Diabetes and Digestive and Kidney Diseases;next generation sequencing;Oral;Patient Care;patient population;Patient-Focused Outcomes;Patients;peer learning;Pelvic Floor Disorders;Postbaccalaureate;posters;Procedures;programs;Quality of life;Race;recruit;Reporting;Research;Research Personnel;Research Project Grants;Research Proposals;Resources;Scientist;skills;Sterility;Students;Surgeon;Techniques;Technology;Thinking;Training;Training Activity;Training Programs;translational approach;Translational Research;treatment response;undergraduate education;undergraduate research experience;undergraduate student;Universities;urinary;Urinary Incontinence;Urinary Microbiome;Urinary tract;Urinary tract infection;Urine;Urologic Diseases;Urologist;Urology;Viral;Virus;Woman;Work;Writing

PROJECT_TITLE: Undergraduate Research Experience in Transdisciplinary Benign Urologic Disease.


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Cerebrovascular;Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

PHR: The proposed research is relevant to the public health because the blood-brain barrier poses a significant obstacle for treating diseases of the central nervous system, representing an enormous national cost as measured by both patient suffering and economic burden. Upon completion of this research, we will understand the genetic factors that regulate the formation and function of the blood-brain barrier. These discoveries will provide new opportunities for the treatment of neurological diseases.

PI_NAMEs: TAYLOR, MICHAEL ROBERT (contact)

PROGRAM_OFFICER_NAME: HEWETT, SANDRA JEANNE

PROJECT_TERMS: Alzheimer's Disease;angiogenesis;antagonist;beta catenin;Binding Sites;Blood - brain barrier anatomy;Blood brain barrier dysfunction;blood-brain barrier function;brain endothelial cell;Brain Neoplasms;Cell membrane;Cell secretion;Cells;Central Nervous System;Central Nervous System Diseases;Cerebrovascular system;cost;CRISPR/Cas technology;Data;Development;Disease;Doxycycline;Economic Burden;Endothelial Cells;Endothelial Growth Factors Receptor;Epilepsy;Gene Transfer Techniques;Genetic;Goals;Imaging Techniques;Immune;in vivo;Infiltration;Inflammatory;innovation;insight;KDR gene;Knowledge;Measures;Mediating;Medulloblastoma;Modeling;Molecular;Multiple Sclerosis;mutant;nerve stem cell;nervous system development;Nervous System Disorder;Neurodegenerative Disorders;Neuroglia;neurological pathology;Neuropilin-1;Pathology;Patients;Peripheral;Permeability;Play;prevent;Process;promoter;Property;protein expression;Proteins;Public Health;Radial;Receptor Signaling;Regulation;Regulatory Element;repaired;Research;Role;Signal Pathway;Signal Transduction;Stroke;Testing;Therapeutic;Therapeutic Agents;Time;Transgenic Organisms;Up-Regulation;Vascular Endothelial Growth Factors;Vesicle;Visualization;WNT Signaling Pathway;Zebrafish

PROJECT_TITLE: Regulation of CNS angiogenesis and barriergenesis


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Hematology;Macular Degeneration;Neurodegenerative;Neurosciences

ORG_CITY: AUGUSTA

ORG_NAME: AUGUSTA UNIVERSITY

PHR: NARRATIVE This proposal seeks to develop a new molecular strategy to limit subretinal fibrosis in blinding eye disease. PFKFB3 (6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase isoform 3) is a critical regulator/activator of glycolysis. The proposed studies are designed to use Pfkfb3 deficient myeloid cells and mice to investigate the involvement of glycolysis in myeloid cells in subretinal fibrosis and to define the underlying mechanisms.

PI_NAMEs: CALDWELL, RUTH B (contact);HUO, YUQING

PROGRAM_OFFICER_NAME: GORDIYENKO, NATALIYA

PROJECT_TERMS: 6-Phosphofructo-2-kinase;6-Phosphofructokinase;Actins;Anatomy;Area;Bone Marrow;cell type;Cells;Choroid;Choroidal Neovascularization;Cicatrix;Citric Acid Cycle;Complex;Data;design;Development;Endothelial Cells;Enzyme Activation;Enzymes;Epithelial Cells;epithelial to mesenchymal transition;Exudative age-related macular degeneration;Eye diseases;Fibrosis;Fructose;Fructose-2,6-bisphosphatase;Genetic;Glycolysis;In Vitro;in vitro Model;in vivo;Inflammatory;inhibitor;knock-down;Lasers;Macrophage;Measures;Mediating;Mesenchymal;Metabolic;Metabolic Pathway;Metabolism;Modeling;Molecular;Mus;Myelogenous;Myeloid Cells;Myofibroblast;Neuroglia;novel strategies;overexpression;Oxygen;Pathway interactions;pharmacologic;Phosphotransferases;Production;Profibrotic signal;Protein Isoforms;retinal angiogenesis;Retinal Diseases;Role;Smooth Muscle;Structure of retinal pigment epithelium;Testing;Therapeutic;tool;treatment strategy;Visual impairment;VLDL receptor

PROJECT_TITLE: "Myeloid PFKFB3 in subretinal fibrosis"

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Cannabinoid Research;Chronic Pain;Complementary and Integrative Health;Machine Learning and Artificial Intelligence;Natural Products;Networking and Information Technology R&D (NITRD);Pain Research

ORG_CITY: HERSHEY

ORG_NAME: PENNSYLVANIA STATE UNIV HERSHEY MED CTR

PHR: PROJECT NARRATIVE While one of the main therapeutic uses of cannabis is to relieve chronic pain, little is known about the underlying mechanisms. We propose using an innovative artificial intelligence (AI) approach to deconvolute the complex mixture of cannabinoids, terpenoids, and flavonoids that comprise cannabis and its extracts and test these in cell and animal models. When we are successful, we will have provided insight into the use of cannabis in pain and validated this paradigm for understanding a variety of other complementary and integrative (natural products) approaches to health.

PI_NAMEs: DOKHOLYAN, NIKOLAY ;VRANA, KENT E (contact)

PROGRAM_OFFICER_NAME: BELFER, INNA

PROJECT_TERMS: 3-Dimensional;Address;Affinity;Agonist;Amino Acid Sequence;Analgesics;Animal Model;antagonist;Artificial Intelligence;Beta-caryophyllene;Binding;Cannabinoids;Cannabis;Cell model;Chemicals;chronic pain;Complement;Complementary Health;Complementary Medicine;Complex;Complex Mixtures;Data Set;Databases;deep learning;Disparate;Docking;drug efficacy;Drug Targeting;Drug usage;Evaluation;Evolution;Exclusion;Flavonoids;genome-wide analysis;Health;Human;humulene;In Vitro;inhibitor;innovation;insight;Integrative Medicine;interest;Intervention;knockout gene;Knowledge;Laboratories;Learning;Ligands;limonene;linalool;Link;Luteolin;Maps;Marijuana;marijuana use;Methods;mind/body;Modality;Modeling;Molecular;Molecular Target;Natural Products;neural network;novel;Organism;Outcome;Output;Pain;pain model;Pathway interactions;Pharmaceutical Preparations;pharmacologic;Pharmacology;Phenotype;Physiological;Physiology;pre-clinical;Process;Property;protein data bank;Proteins;PubMed;Quercetin;Research;response;Science;small molecule;Smoke;Structure;Techniques;Terpenes;Testing;text searching;Therapeutic;Therapeutic Uses;three dimensional structure;tool;web server;Work

PROJECT_TITLE: AI-based Mapping of Complex Cannabis Extracts in Pain Pathways

STUDY_SECTION: BDMA

STUDY_SECTION_NAME: Biodata Management and Analysis Study Section[BDMA]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

PHR: Project Narrative Leishmania donovani cause the fatal human disease visceral leishmaniasis for which the treatments are often toxic, ineffective, and are facing resistance. This proposal seeks to develop a versatile genetic tool that can be used to identify proteins that are important for parasite survival or that cause the parasites to resist drug treatments. The information gleaned from these studies could be useful in developing new drugs to treat these devastating diseases.

PI_NAMEs: YATES, PHILLIP A (contact)

PROGRAM_OFFICER_NAME: JOY, DEIRDRE A

PROJECT_TERMS: Acceleration;Bar Codes;Biology;Cells;Communities;Complex;CRISPR/Cas technology;Defect;Disease;DL-alpha-Difluoromethylornithine;dosage;drug action;Drug resistance;Drug Targeting;Ensure;experience;experimental study;Expression Library;expression vector;fitness;Gene Expression Regulation;Generations;Genes;Genetic;genetic regulatory protein;Genetic Screening;Genetic Techniques;genome-wide;Genomic Library;Glean;Goals;Growth;human disease;Hyperactivity;Incidence;Individual;inducible gene expression;innovation;knock-down;Laboratories;Leishmania;Leishmania donovani;Libraries;Life Cycle Stages;loss of function;Melarsoprol;Methods;Molecular Genetics;neglected tropical diseases;new therapeutic target;novel;novel therapeutics;Open Reading Frames;Ornithine Decarboxylase;Ornithine Decarboxylase Inhibitor;overexpression;Parasites;Pathway interactions;Persons;Pharmacotherapy;Phenotype;Plasmids;protein expression;protein function;Proteins;Reproducibility;Resistance;resistance gene;resistance mechanism;Resources;Ribosomal RNA;RNA Interference;RNA interference screen;Signal Transduction;Stress;System;Time;tool;Transfection;Trypanosoma brucei brucei;Trypanosoma cruzi;Validation;vector;Visceral;Visceral Leishmaniasis;Yeasts

PROJECT_TITLE: Generation and validation of a novel inducible overexpression library for genome-scale genetic screens in Leishmania

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IIDA-F(02)]


NIH_SPENDING_CATS: Clinical Research;Hematology;Infectious Diseases;Prevention;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

PHR: Hematopoietic stem cell transplant (HSCT) is an essential procedure in treating patients with leukemia and other cancers. However, the transplant also temporarily reduces the number of neutrophils, an essential white blood cell population necessary for protection against infections with invasive fungi like Candida albicans. This project will help develop new tools to measure the function of neutrophils directly in HSCT patients and determine how fast neutrophil functions return to normal and restore the protection against invasive fungi.

PI_NAMEs: IRIMIA, DANIEL  (contact);LIN, CHARLES P.;MANSOUR, MICHAEL K

PROGRAM_OFFICER_NAME: JOFFE, AARON MICHAEL

PROJECT_TERMS: Acceleration;accurate diagnosis;Address;anti-fungal agents;Azoles;Biological Markers;Candida;Candida albicans;Candida auris;Candida glabrata;candidemia;Candidiasis;Cells;chemokine;Communication;CSF3 gene;cytokine;design;Diagnosis;Early Diagnosis;Effectiveness;Engineering;Enrollment;first responder;Functional disorder;functional restoration;Fungal Drug Resistance;fungus;Future;Goals;Growth;Hematologic Neoplasms;Hematopoietic Stem Cell Transplantation;high risk;Hospitalization;Human;human imaging;Hyphae;Image;Imaging Techniques;Immune response;improved;improved outcome;In Vitro;in vivo;in vivo monitoring;Individual;Infection;infection risk;Injury;Knowledge;Label;leukemia;Leukocytes;Life;Malignant Neoplasms;Measurement;Measures;Microscopic;Molecular;Monitor;Morbidity - disease rate;mortality;Mycoses;neutrophil;novel imaging technology;Outcome;patient stratification;Patients;Performance;Phagocytosis;Population;post-transplant;Predisposition;Procedures;Prophylactic treatment;Recovery;Research;Resistance;restoration;Risk;Risk Estimate;Risk Factors;Risk Reduction;Role;Site;Stem cell transplant;Techniques;Therapeutic;Time;tissue injury;tool;Transplant Recipients;Transplantation

PROJECT_TITLE: In vivo Monitoring of Neutrophil Function in Patients after Stem Cell Transplant

STUDY_SECTION: IHD

STUDY_SECTION_NAME: Immunity and Host Defense Study Section[IHD]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Eye Disease and Disorders of Vision;Macular Degeneration;Neurodegenerative;Neurosciences

ORG_NAME: SMITH-KETTLEWELL EYE RESEARCH INSTITUTE

PHR: HEALTH RELEVANCE The ability to move the eyes to find objects, and the ability to use information about depth is critical to the safe execution of everyday tasks that require eye-hand coordination and navigating through the environment safely. Comprehensive rehabilitation of individuals with central field loss could have dramatic results in helping them achieve a full independent lifestyle. Our findings will lay the groundwork for therapies that maximize residual visual function and help create an important intervention for the successful rehabilitation of individuals with AMD.

PI_NAMEs: VERGHESE, PREETI  (contact)

PROGRAM_OFFICER_NAME: WIGGS, CHERI

PROJECT_TERMS: Address;Adopted;Affect;Age;Age related macular degeneration;Attention;Awareness;Behavior;Blindness;Central Scotomas;central visual field;Compensation;Coupled;Coupling;Cues;Depth Perception;Development;Disparity;Drops;Environment;experience;Eye;eye hand coordination;Eye Movements;fovea centralis;functional loss;Funding;Future;Goals;Hand;Health;Impairment;improved;Individual;interest;Intervention;Life;Life Style;Location;Macular degeneration;Mediating;monocular;Motion;Movement;oculomotor;Peripheral;Population;portability;Reading;Rehabilitation therapy;Research;Residual state;Retina;Saccades;sample fixation;Scotoma;stereoscopic;Stimulus;Time;virtual reality headset;Vision;Visual;Visual Acuity;visual discrimination;Visual Fields;visual motor

PROJECT_TITLE: Maximizing Visual Potential in Age-related Macular Degeneration


ADMINISTERING_IC: MD

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_DEPT: SOCIAL SCIENCES

PHR: PROJECT NARRATIVE This study will advance knowledge on racial health disparities by quantifying and characterizing the health consequences of black–white disparities in exposure to death from extended kin and household members. This research has the potential to initiate new substantive and methodological avenues to further investigate how improvements to black life expectancy may not only benefit individuals, but also have positive effects on the health of other social network members. Further, identifying mechanisms linking early and multiple exposures to death to later adverse health outcomes will promote adoption of multilevel interventions targeting social determinants of health to mitigate this potential intergenerational driver of inequality.

PI_NAMEs: DIXON, ANGELA R (contact)

PROGRAM_OFFICER_NAME: MUJURU, PRISCAH

PROJECT_TERMS: Achievement;Adoption;Adult;Age;Bereavement;biopsychosocial;Black Populations;black/white disparity;Cessation of life;Child;Communities;Complex;COVID-19;COVID-19 mortality;COVID-19 stress;Data;Death Rate;Demography;design;Disparity;economic outcome;Equation;evidence base;experience;Exposure disparity;Exposure to;Extended Family;Family;Family health status;Family Leave;Family member;Feedback;Generations;grandparent;Health;health inequalities;Health Insurance;Health Status;High Prevalence;Household;Household and Family;improved;Individual;Inequality;Inequity;innovation;Insurance Coverage;intergenerational;Intervention;Interview;Kinship Networks;Knowledge;Latin America;Left;Life Cycle Stages;Life Expectancy;Link;Literature;loved ones;low socioeconomic status;Mediating;member;Mental Health;Mentors;Methodology;Methods;Michigan;Modeling;mortality;mortality risk;novel;Nuclear Family;Outcome;panel study of income dynamics;Pathway Analysis;Pathway interactions;perceived discrimination;physical conditioning;Play;Policies;Population;premature;Prevalence;psychological distress;Psychosocial Stress;Race;racial disparity;racial health disparity;racism;Research;Research Personnel;Resources;Rest;Risk;Role;Running;Shapes;Siblings;social;social epidemiology;social health determinants;Social Network;social structure;Societies;socioeconomic disparity;Socioeconomic Factors;Socioeconomic Status;socioeconomics;Sociology;Source;Stressful Event;Structure;Survival Analysis;Survivors;System;theories;Time;tool;Training;Universities;Work

PROJECT_TITLE: The Loved Ones Left Behind: Examining the Health Implications of Racial Inequities in Mortality


NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Clinical Research;Disability Research;Eye Disease and Disorders of Vision;Networking and Information Technology R&D (NITRD);Rehabilitation

PHR: Health Relevance For people who are blind or visually impaired, a serious barrier to employment, economic self- sufficiency and independence is insufficient access to a wide range of everyday objects needed for daily activities that require visual inspection on the part of the user. Such objects include printed documents, maps, infographics, appliances and 3D models used in science, technology, engineering, and mathematics (STEM), and are abundant in schools, the home and the workplace. The proposed research would result in a powerful camera-based smartphone app to provide increased access to such objects for the approximately 10 million Americans with significant vision impairments or blindness.

PI_NAMEs: COUGHLAN, JAMES M (contact)

PROJECT_TERMS: 3-Dimensional;American;Architecture;Augmented Reality;blind;Blindness;braille;Cellular Phone;Computer software;design;Development;Devices;devices for the visually impaired;Documentation;Economics;Employment;Ensure;Evaluation;experience;Fingers;Glass;Goals;Grant;haptics;Health;Hearing;Home;Image Enhancement;improved;interest;Label;Location;Maps;Modeling;open source;Output;Performance;Persons;Printing;prototype;Reader;Research;Research Personnel;Schools;Science, Technology, Engineering and Mathematics;smartphone application;System;Tactile;three-dimensional modeling;Touch sensation;Vision;Visual;Visual impairment;wearable device;Work;Workplace

PROJECT_TITLE: Point and Listen: Augmented Reality Interfaces for the Visually Impaired


ORG_CITY: BLACKSBURG

ORG_DEPT: BIOLOGY

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

ORG_STATE: VA

PHR: PROJECT NARRATIVE  The goal of this project is to characterize fundamental mechanisms underlying the development of exhausted memory monocytes with pathogenic inflammation and immune-suppression, novel memory features of exhausted innate immunity bearing important relevance during the progression of sepsis pathogenesis associated with polymicrobial infections.

PI_NAMEs: LI, LIWU  (contact)

PROGRAM_OFFICER_NAME: MINNICOZZI, MICHAEL

PROJECT_TERMS: Acute;Animals;Anti-Inflammatory Agents;Attenuated;CD86 gene;Cell Maturation;Characteristics;Chronic;Clustered Regularly Interspaced Short Palindromic Repeats;computer studies;Connexin 43;Development;exhaust;exhaustion;Exhibits;experience;experimental study;Failure;Generations;Genetic;Goals;Homeostasis;Human;Immature Monocyte;Immune;immune activator;Immunosuppression;Immunosuppressive Agents;in vivo;Infection;Inflammation;Inflammation Mediators;Inflammatory;inflammatory marker;Intervention;Mediating;Mediator;Memory;Metabolic;monocyte;Morbidity - disease rate;mortality;multiorgan injury;Mus;Mycolic Acid;Myelogenous;Myeloid-derived suppressor cells;Natural Immunity;new therapeutic target;NF-kappa B;novel;Pathogenesis;Pathogenicity;Patients;pharmacologic;Phenotype;prevent;programmed cell death ligand 1;Proto-Oncogene Proteins c-akt;Reporting;S100A8 gene;secondary infection;Sepsis;septic;septic patients;Severities;Signal Transduction;single-cell RNA sequencing;STAT1 gene;Testing;Therapeutic;therapeutically effective;TLR4 gene;tool;translational potential

PROJECT_TITLE: Modulation of innate immune exhaustion during sepsis

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research

ORG_CITY: JERUSALEM

ORG_COUNTRY: ISRAEL

ORG_FIPS: IS

ORG_NAME: HEBREW UNIVERSITY OF JERUSALEM

PHR: The concept of overall well-being provides an important perspective for thinking about public health. Within the study of well-being, assessing which individuals have higher well-being and which individuals have lower well-being is crucial in order to use cross-sectional data to study the determinants of well-being and in order to study inequality in well-being. This project develops methods for comparing overall well-being across individuals even when individuals differ in how they use response scales and well-being has many aspects, and uses those methods to study how well-being varies across individuals and over time, including how it varies across different stages of life.

PI_NAMEs: HEFFETZ, ORI  (contact)

PROGRAM_OFFICER_NAME: JAIN, KRITI MUNJAL

PROJECT_TERMS: Academy;Address;Aging;American;Area;Behavior;Behavioral;Behavioral Research;Binding;Calibration;Caring;Consumption of goods;Data;Data Collection;Development;Dimensions;Disadvantaged;Economic Models;Economics;Emotions;Ethics;experience;Foundations;Future;Goals;Health;improved;Individual;Individual Differences;Inequality;Intervention;Investments;large scale data;Life;Life Cycle Stages;Light;Maps;Marketing;Measurement;Measures;Methodology;Methods;middle age;Mission;Movement;multidimensional data;Narcissism;National Institute on Aging;Nature;optimism;Pain;Patient Self-Report;Pattern;Personal Satisfaction;Persons;Play;Policies;Policy Making;Privatization;psychologic;Psychology;Public Health;Published Comment;Publishing;Recommendation;Reporting;Research;Research Personnel;Respondent;response;Role;skills;social;Social Desirability;Social outcome;Social Sciences;Social Welfare;Societies;Source;Surveys;Testing;theories;Thinking;Time;tool;United States National Institutes of Health;welfare;Work

PROJECT_TITLE: Measuring Well-Being and Its MultidimensionalDeterminants Across Individuals and the Life Course


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Genetics;Immunotherapy;Liver Cancer;Liver Disease;Rare Diseases

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Project narrative Tumor-associated macrophages (TAM) are responsible for supporting an environment that promotes cancer progression and invasion. The goal of our project is to understand the underlying mechanisms of how function, differentiation and tumor infiltration of TAM are regulated by a cell stress regulator, CNPY2, within tumor microenvironment. The results from this study will be used to design TAM-targeted cancer immune therapies.

PI_NAMEs: HONG, FENG  (contact)

PROGRAM_OFFICER_NAME: KUO, LILLIAN S

PROJECT_TERMS: Ablation;Address;Attenuated;Biochemical;Biochemistry;Biometry;Cancer Biology;cancer cell;cancer type;Carcinogens;Cell Death Induction;cell motility;Cells;Cellular Stress;Cessation of life;Chemicals;Chronic;coping;cytokine;Cytoprotection;Data;Data Set;design;Development;Diagnosis;Diethylnitrosamine;drug development;Endoplasmic Reticulum;endoplasmic reticulum stress;Ensure;Environment;Epidemic;Exposure to;FLT1 gene;Foundations;Functional disorder;Genetic;genetic approach;Genetic Transcription;Goals;Hepatic;Hepatotoxicity;Homologous Gene;Hypoxia;IL6 gene;Immune;Immunology;Immunosuppression;Immunotherapy;improved;Infectious Agent;Infiltration;Inflammation;Inflammatory;inhibitor;Invaded;ITGAM gene;KDR gene;Knock-out;Knockout Mice;Kupffer Cells;Ligands;Liver;liver function;Macrophage;Malignant neoplasm of liver;Malignant Neoplasms;Mediating;Mediation;migration;Modeling;mouse model;Mus;Myeloid Cells;new therapeutic target;novel;Nutrient;Oncology;Pathology;Pathway interactions;Persons;Play;prevent;Primary carcinoma of the liver cells;Production;Proliferating;Proteins;proteostasis;Public Health;Quality Control;rational design;Receptor Signaling;Regulation;Research;Research Personnel;response;Role;Signal Transduction;structural biology;Structure;success;synergism;System;Therapeutic;TLR4 gene;TNF gene;Toll-like receptors;Transactivation;transcription factor CHOP;transcriptome sequencing;tumor;tumor growth;Tumor Immunity;tumor initiation;tumor microenvironment;tumor progression;Tumor Promotion;Tumor-associated macrophages;tumorigenesis;United States;Wild Type Mouse;Work

PROJECT_TITLE: Defining the role of CNPY2 in promoting tumor progression through mediation of macrophage.

STUDY_SECTION: TTT

STUDY_SECTION_NAME: Transplantation, Tolerance, and Tumor Immunology Study Section[TTT]


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Epilepsy;Genetics;Neurodegenerative;Neurosciences;Precision Medicine

PHR: PROJECT NARRATIVE The proposed research is relevant to public health as more precise measurement of clinical data in genetic epilepsies and neurodevelopmental disorders is ultimately expected to translate into improved diagnostics, allowing for greater personalized treatment choices. Thus, the proposed research is relevant to the purpose of the RFA and mission of the NINDS by providing a dedicated program to delineate subgroups of epilepsies for better stratification of current and future treatments, thereby reducing the burden of neurological disease.

PI_NAMEs: HELBIG, INGO  (contact)

PROGRAM_OFFICER_NAME: WHITTEMORE, VICKY R

PROJECT_TERMS: Accounting;Address;Age;Age Factors;Anticonvulsants;Brain Diseases;childhood epilepsy;Clinical;clinical care;Clinical Data;clinical practice;cohort;Comparative Effectiveness Research;Complex;computerized tools;Consumption;Data;Data Analyses;data harmonization;Dedications;Demographic Factors;Development;Diagnostic;dietary;Disease;effective therapy;Epilepsy;Freedom;Frequencies;Future;Genes;Genetic;Genetic Predisposition to Disease;genetic variant;Genotype;Goals;Human;implantation;improved;Individual;Intervention;ketogenic diet;Knowledge;Language;longitudinal analysis;loss of function;Manuals;Maps;Measurement;Methods;Mission;National Institute of Neurological Disorders and Stroke;Natural History;Nerve;Nervous System Disorder;Neurodevelopmental Disorder;novel strategies;Ontology;Operative Surgical Procedures;Outcome;outcome prediction;oxcarbazepine;Patients;Pattern;personalized medicine;Pharmaceutical Preparations;Phenotype;phenotypic data;Positioning Attribute;Prognosis;programs;Public Health;Rare Diseases;reconstruction;Recording of previous events;Research;response;Saint Jude Children's Research Hospital;SCN8A gene;Seizures;Sodium Channel Blockers;Standardization;Stratification;Subgroup;Therapeutic;Time;Translating;treatment and outcome;treatment choice;treatment comparison;treatment response;treatment strategy;Variant

PROJECT_TITLE: Subgroup delineation in genetic epilepsies and developmental brain disorders

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Diabetes;Digestive Diseases;Genetics;Women's Health Research

ORG_CITY: Chicago

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: The PI3K/Akt signaling is frequently hyperactivated in cancer. However, targeting this pathway is often associated with adverse effects, which either prohibit further treatment or decrease the efficacy of Akt inhibition. The goal of this grant application is to find ways to inhibit Akt effectively for the therapy of cancer and cancer metastasis, and to mitigate adverse consequences.

PI_NAMEs: HAY, NISSIM  (contact)

PROGRAM_OFFICER_NAME: WATSON, JOANNA M

PROJECT_TERMS: Address;Adult;Adverse effects;adverse outcome;Affect;Aftercare;AKT inhibition;Anti-diabetic Drugs;Apoptosis;Apoptotic;Applications Grants;Bone Marrow;BRCA1 gene;breast cancer metastasis;Breast Cancer Model;Breast Cancer therapy;cancer cell;Cancer Model;cancer therapy;Cell Aging;Cell Cycle Checkpoint;Cell Death;Cell Survival;Cells;checkpoint inhibition;Colitis;Contact Inhibition;Development;Diabetes Mellitus;Diarrhea;Disease-Free Survival;effective therapy;Endometrial Neoplasms;Enzymes;Event;Funding;Generations;Genes;Genetic;Genetic study;Genetic Transcription;Glycolysis;Goals;hexokinase;Hexokinase 2;Human;Hyperglycemia;Hyperinsulinism;Impairment;in vivo;Inflammation;inhibitor;Insulin;Intestines;Leptin;Leptin deficiency;lipid biosynthesis;liver injury;Lymphocyte;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary gland;Mediating;Metabolic;Mitochondria;mortality;mouse model;mRNA Translation;Mus;Natural Immunity;Nature;Neoplasm Metastasis;neutrophil;Non-Insulin-Dependent Diabetes Mellitus;novel;Oncogenes;Oncogenic;overexpression;Pathway interactions;Patients;Pharmaceutical Preparations;Pharmacotherapy;Phenotype;Physiological;PIK3CG gene;premature;Primary carcinoma of the liver cells;Primary Neoplasm;programs;Prostatic Neoplasms;Protein Isoforms;PTEN gene;Reporting;Resistance;response;Role;senescence;Signal Transduction;single cell mRNA sequencing;Skin tumorigenesis;Stress;Testing;Time;triple-negative invasive breast carcinoma;tumor;tumor progression

PROJECT_TITLE: PI3K/PTEN/Akt signaling and the genesis of cancer

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 1 Study Section[MCT1]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Eye Disease and Disorders of Vision;Mental Health;Neurosciences

ORG_CITY: PITTSBURGH

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative Building a model of the neural basis of natural, real-world social vision is a fundamental goal of social neuroscience. Natural social vision depends critically on an active process of information gathering and the intricate interplay among many brain regions that rapidly adapt in response to the properties of the social environment. Understanding the neural basis of natural, real-world social vision will directly inform our understanding of the neural basis of neurological and psychiatric disorders that involve aberrant social processing, such as mood disorders, anxiety disorders, autism spectrum disorders, schizophrenia, traumatic brain injury, Parkinson’s disease, and post-traumatic stress disorder.

PI_NAMEs: DE LA TORRE, FERNANDO ;GHUMAN, AVNIEL S (contact);SCHROEDER, CHARLES E

PROGRAM_OFFICER_NAME: BREEDEN, ANDREW LEE

PROJECT_TERMS: active vision;Affective;Anxiety Disorders;Attention;Attitude;autism spectrum disorder;Behavior;Brain;Brain region;brain surgery;Code;Cognitive;Complex;Computer Analysis;computer framework;Computer Models;Computer Vision Systems;Cues;Data;Diffusion;Emotions;Environment;Epilepsy;Event;experience;experimental study;Eye;Eye Movements;Face;Facial Expression;Family;Frequencies;Friends;Future;gaze;Goals;Head Movements;Hospitals;Hour;Human;Image;Implanted Electrodes;information gathering;information processing;Laboratories;Learning;Machine Learning;Maps;Measurement;Measures;Mental disorders;Methods;model design;Modeling;Monitor;Mood Disorders;Motion;Motor;movie;multisensory;Nervous System Disorder;neural;neural model;Neurobiology;Neurocognitive;novel;Nurses;operation;Operative Surgical Procedures;Parkinson Disease;Participant;Patients;Pattern;Perception;Persons;Phase;Play;Population;Post-Traumatic Stress Disorders;Process;Property;prototype;Recording of previous events;Relaxation;response;Role;Saccades;sample fixation;Sampling;scaffold;Schizophrenia;Signal Transduction;social;Social Behavior;social deficits;Social Environment;Social Interaction;social neuroscience;Social Perception;spatiotemporal;Stimulus;Structure;System;Techniques;Testing;Time;Traumatic Brain Injury;Update;Variant;Vision;Visual;visual information;visual neuroscience;visual processing;Visual System;visual tracking;Work

PROJECT_TITLE: Active Social Vision: How the Brain Processes Visual Information During Natural Social Perception