NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Gene Therapy;Genetics;Hematology;Human Genome;Immunotherapy;Lymphatic Research;Lymphoma;Orphan Drug;Rare Diseases

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

PHR: PROJECT NARRATIVE . Diffuse large B-cell lymphoma (DLBCL) is the most common type of lymphoma with a very poor prognosis for patients who are diagnosed with relapsed or refractory (r/r) disease. Here we propose to test a promising treatment approach combining a clinical stage intravenously administered oncolytic Vesicular stomatitis virus (VSV) with a novel dually targeted checkpoint inhibitor (ONIx) in dogs with r/r DLBCL, to guide clinical development of this novel combination therapy for patients with r/r DLBCL. Detailed analyses to characterize the impact of combination therapy on the DLBCL tumor architecture and comparison of features of tumor microenvironment in responding versus nonresponding dogs will allow us to identify potential, clinically actionable biomarkers of response.

PI_NAMEs: MODIANO, JAIME F.;NAIK, SHRUTHI  (contact)

PROGRAM_OFFICER_NAME: SOMMERS, CONNIE L

PROJECT_TERMS: Agitation;anti-tumor immune response;Antigen Presentation;Architecture;Biological;biomarker identification;cancer heterogeneity;Canis familiaris;Cells;Chemotherapy-Oncologic Procedure;Clinic;Clinical;clinical development;Clinical Research;clinically actionable;cohort;Combined Modality Therapy;companion animal;comparative;Correlative Study;Cytolysis;Data;design;Diagnosis;Dose;Engineering;Gene Expression Profiling;Genomics;Heterogeneity;Hodgkin Disease;Human;Immune;immune checkpoint blockade;Immune checkpoint inhibitor;immunogenic;Immunooncology;immunoregulation;Immunosuppression;Immunotherapy;improved;improved outcome;Individual;insight;Institution;Intravenous;intravenous administration;large cell Diffuse non-Hodgkin's lymphoma;Lymphoma;Macrophage;Malignant Neoplasms;Measures;Mediating;Methods;Minnesota;Modeling;Mus;Mutation;nano-string;neoplastic cell;Non-Hodgkin's Lymphoma;novel;Oncology;oncolytic Vesicular Stomatitis Virus;Oncolytic viruses;Outcome;Pathology;patient prognosis;patient response;Patients;Peptides;Phagocytosis;pre-clinical;Prognosis;prospective;Recurrent disease;Refractory;refractory cancer;Refractory Disease;Regimen;Relapse;Resistance;Resources;responders and non-responders;response;response biomarker;Safety;Sampling;single cell sequencing;Specimen;survival outcome;Systemic Therapy;T cell response;T-Lymphocyte;Testing;Therapeutic;tool;Toxic effect;Translations;tumor;Tumor Antigens;Tumor Immunity;tumor microenvironment;Tumor-infiltrating immune cells;Universities;Vesicular stomatitis Indiana virus;Viral;virus development

PROJECT_TITLE: Translation of a novel combination therapy approach for non-Hodgkin lymphoma


ADMINISTERING_IC: HG

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

ORG_CITY: GRAND RAPIDS

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: VAN ANDEL RESEARCH INSTITUTE

ORG_STATE: MI

PHR: PROJECT NARRATIVE It is remarkable that ~50% of phenotypic variation and disease in twins and inbred organisms cannot be explained by genetics or environmental effects. We suggest that a significant portion of unexplained disease heterogeneity reflects molecularly encoded but inherently probabilistic properties of the genome, evolved to generate variability within any given context. If true, then we will open the door to a third dimension of precision medicine that answers “what is a normal physiological state for me”, and harness that insight to develop fundamentally new predictive, diagnostic, and therapeutic interventions, irrespective of the disease of interest.

PI_NAMEs: NADEAU, JOSEPH H.;POSPISILIK, JOHN ANDREW (contact)

PROGRAM_OFFICER_NAME: PAZIN, MICHAEL J

PROJECT_TERMS: Address;Animal Model;Architecture;Area;Atlases;Biological;Biological Models;biological systems;Biomedical Research;Catalogs;Chromosomes;cohort;Communities;Complex;Data;data resource;Databases;Development;Diagnosis;Diagnostic;Dimensions;Disease;disease heterogeneity;Diseases in Twins;disorder risk;driving force;Environment;Epigenetic Process;Etiology;Gene Activation;Gene Expression;Gene Silencing;Genes;Genetic;Genome;genome-wide;Genotype;Heterogeneity;Human;human disease;Human Genetics;Inbreeding;Individual;innovation;insight;interest;International;Knowledge;late life;Lead;Link;Mainstreaming;Measures;Medicine;Metabolic;Methods;Molecular;Monozygotic twins;Mus;Neurologic;non-genetic;Organism;Outcome;Persons;Phenotype;Phylogenetic Analysis;Physiological;Population;precision medicine;Precision Medicine Initiative;Process;Property;Protocols documentation;Quantitative Trait Loci;Regulator Genes;Reporting;Science;Seminal;Standardization;Surveys;Testing;Therapeutic Intervention;trait;Variant;Vertebrates;Work

PROJECT_TITLE: Master regulators of unexplained variation in disease risk

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-J(70)R]


ADMINISTERING_IC: AT

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Complementary and Integrative Health;Prevention;Substance Misuse;Telehealth;Tobacco;Tobacco Smoke and Health

ORG_CITY: TUCSON

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: PROJECT NARRATIVE The goal of the proposed project is to conduct a randomized clinical efficacy trial (RCT) of a novel guided imagery tobacco cessation intervention delivered by phone. The results of our feasibility trial conducted in Arizona demonstrated feasibility and potential impact but was not powered to detect efficacy. Therefore, a fully powered RCT is warranted and will be conducted in collaboration with partners in Arizona, New York, and West Virginia.

PI_NAMEs: GORDON, JUDITH SARAH (contact)

PROGRAM_OFFICER_NAME: MUDD, LANAY MARIE

PROJECT_TERMS: Abstinence;Accounting;Address;Adherence;Adult;aged;American;Arizona;behavior change;Behavior Control;Behavior Therapy;Behavioral;Biochemical;Bupropion;Cause of Death;Cessation of life;cigarette smoke;cigarette smoking;Clinical;Collaborations;comparison control;Consumer Satisfaction;Data;Dependence;design;Disease;disorder risk;Dose;efficacy clinical trial;efficacy evaluation;efficacy testing;Electronic cigarette;Enrollment;Ethnic Origin;evidence base;experience;Exposure to;Feasibility Studies;feasibility trial;follow up assessment;follow-up;Goals;Guam;Guided imagery;Image;improved;Individual;innovation;Integrative Medicine;Internet;Intervention;intervention effect;Interview;Location;Measures;Methods;Mind-Body Intervention;Modeling;Monitor;Motivation;multisensory;National Center for Complementary and Integrative Health;New York;nicotine replacement;nicotine use;novel;novel strategies;Outcome;Participant;patient engagement;Patient Recruitments;Patient Self-Report;Persons;Population;Population Heterogeneity;Prevalence;primary outcome;Procedures;programs;Protocols documentation;Psyche structure;Public Health;Puerto Rico;quitline;Race;Randomized;Randomized, Controlled Trials;Recommendation;recruit;reduce tobacco use;relapse prevention;Reporting;response;Risk Reduction;Sample Size;sex;skills;Smoke;Smoker;Smoking;smoking abstinence;smoking cessation;Smoking Cessation Intervention;Standardization;Subgroup;Surveys;Techniques;Technology;Telephone;telephone based;telephone delivery;therapeutically effective;Tobacco;tobacco cessation intervention;Tobacco use;Tobacco Use Cessation;tobacco user;tool;Training;United States;Universities;usability;Visualization;West Virginia

PROJECT_TITLE: Testing the Efficacy of A Scalable, Telephone-Delivered, Guided Imagery Tobacco Cessation Intervention


ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: SEATTLE

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: NARRATIVE Genomics is integral to modern biomedical research and diagnosis. Genome-wide studies are used to identify potential genetic causes of disease and investigate fundamental questions of biology and development. Our program will train pre- and postdoctoral trainees for future biomedical and interdisciplinary research in genomics, proteomics and computational biology.

PI_NAMEs: TRAPNELL, BRUCE COLSTON (contact)

PROGRAM_OFFICER_NAME: FUFA, TEMESGEN D

PROJECT_TERMS: genome sciences;Training

PROJECT_TITLE: Interdisciplinary Training in Genome Sciences

STUDY_SECTION: GNOM

STUDY_SECTION_NAME: Genome Research Study Section[GNOM-G]


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

ORG_CITY: DAVIS

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

ORG_STATE: CA

PHR: PROJECT NARRATIVE Polychlorinated biphenyls (PCBs) continue to pose a significant risk to human health, and both human and animal studies have identified the developing brain as a target of concern. While developmental exposures to at least a subset of the higher chlorinated PCBs found in the commercial PCB mixtures synthesized prior to the worldwide ban on PCB production have been identified as developmental neurotoxicants, the potential for the contemporary lower-chlorinated PCBs (LC-PCBs) that are detected in human brain and blood to interfere with neurodevelopment is understudied. The objective of the proposed research is leverage primary neuron-glia co- cultures derived from a unique animal model to evaluate the developmental neurotoxicity of LC-PCBs found in human tissues.

PI_NAMEs: BADLEY, JESSIE RENEE (contact)

PROGRAM_OFFICER_NAME: HOLLANDER, JONATHAN

PROJECT_TERMS: Address;Air;Animal Model;Animals;Arizona;axon growth;Biological;Biological Assay;Blood;Brain;Child;Chlorine;Coculture Techniques;Cyclic AMP-Responsive DNA-Binding Protein;CYP2B6 gene;Cytochrome P450;Data;Development;developmental neurotoxicity;dietary;diphenyl;disorder risk;Environment;epidemiology study;experimental study;Exposure to;Food;Funding;gain of function mutation;gene environment interaction;Genetic Polymorphism;Growth;Health;Heritability;High Risk Woman;Hippocampus;Human;Human Milk;human tissue;Hydroxyl Radical;In Vitro;Industrialization;insight;Iowa;knock-down;Mediating;Metabolism;Molecular;Molecular Target;Morphogenesis;Mus;National Institute of Environmental Health Sciences;Neonatal;neonatal mice;neurodevelopment;Neurodevelopmental Disorder;Neuroglia;neuron apoptosis;Neurons;neuropsychiatry;neurotoxic;Neurotoxins;novel;Outcome;oxidation;Parents;pharmacologic;Polychlorinated Biphenyls;Populations at Risk;Predisposition;Pregnancy;Pregnant Women;Process;Production;Reporting;Research;Research Design;Risk;Risk Assessment;Rodent;Role;Sampling;Serum;Signal Pathway;Signal Transduction;Signaling Protein;Small Interfering RNA;Sulfate;Testing;Universities;Water

PROJECT_TITLE: Investigating the cellular and molecular mechanisms of lower-chlorinated polychlorinated biphenyl developmental neurotoxicity


ADMINISTERING_IC: EY

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision

ORG_CITY: BALTIMORE

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative  The Wilmer K12 mentored training program has produced 44 vision researchers who carry out investigations into blinding diseases, providing protected time to learn research methods and transition to research-intensive careers to produce of new diagnostic and treatment solutions in ophthalmology.

PI_NAMEs: HANDA, JAMES T (contact);QUIGLEY, HARRY ALAN

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: Area;Biomedical Engineering;career;Chairperson;Clinical;Collaborations;computer science;cost;Department chair;Development;Direct Costs;Ensure;Environment;Epidemiology;Evaluation;experience;Eye;Faculty;flexibility;Funding;Grant;Guidelines;Health Sciences;Individual;Institution;International;K-Series Research Career Programs;Laboratories;medical schools;Medicine;member;Mentored Clinical Scientist Development Program;Mentors;Neurosciences;Ophthalmology;Physics;programs;Progress Reports;Public Health Schools;Publishing;recruit;Research;Research Personnel;Research Project Grants;Role;Scholars Program;Scientist;square foot;Structure;Study Section;success;timeline;Training;United States National Institutes of Health;Universities;Update;Vision;Vision research;vision science;Writing

PROJECT_TITLE: The Wilmer Institute Mentored Clinician Scientist Scholar Program


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering

ORG_CITY: TALLAHASSEE

ORG_DEPT: CHEMISTRY

ORG_NAME: FLORIDA STATE UNIVERSITY

ORG_STATE: FL

PHR: Project Narrative The Southeastern Center for Microscopy of MacroMolecular Machines (SECM4), at Florida State University will be a service center that will enable cryo-EM sample preparation, screening, high- resolution data collection, and training for universities around the Southeast. The SECM4 will lower the barrier to access to cryo-EM for users by making expensive cryo-EM instrumentation available without requiring universities to build their own facilities. The SECM4 will achieve further economies of scale by addressing the biggest bottleneck in cryo-EM right now which is by improving cryo-EM specimen optimization and screening.

PI_NAMEs: STAGG, SCOTT M (contact)

PROGRAM_OFFICER_NAME: FLICKER, PAULA F

PROJECT_TERMS: 3-Dimensional;Address;Air;air sampling;Buffers;Centrifugation;Charge;Client;Collaborations;computerized data processing;cost;Cryo-electron tomography;Cryoelectron Microscopy;Data;Data Analyses;Data Collection;Devices;Educational workshop;Explosion;Fees;Florida;Generations;Grant;high throughput screening;improved;instrumentation;interest;Internet;Investments;member;Microscope;microscopic imaging;Microscopy;Monitor;Negative Staining;particle;Persons;Preparation;preservation;reconstruction;Research Personnel;Resolution;Resources;sample fixation;Sampling;Scanning;screening;Services;Site;Specimen;structural biology;Structure;theories;Time;Titan;tomography;Training;Travel;United States National Institutes of Health;Universities;Water

PROJECT_TITLE: The Southeastern Center for Microscopy of Macromolecular Machines (SECM4)


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Aging;Arthritis;Autoimmune Disease;Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Emerging Infectious Diseases;Infectious Diseases;Orphan Drug;Pain Research;Rare Diseases;Vector-Borne Diseases

ORG_CITY: WASHINGTON

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: GEORGE WASHINGTON UNIVERSITY

ORG_STATE: DC

PHR: NARRATIVE The objective of this proposal is to determine the efficacy and histopathologic effects on synovitis of 6 months of methotrexate (n=100) versus placebo (n=50) therapy for chronic CHIKV arthritis in Colombia in a randomized controlled trial. Our central hypothesis is that methotrexate will significantly decrease chronic CHIKV arthritis disease severity compared to placebo and suppress leukocyte accumulation and inflammatory cytokine expression in synovial tissue. In Aim 1, we will determine the efficacy of oral methotrexate treatment versus placebo for 6 months in chronic CHIKV arthritis, in Aim 2, we will determine the effect of methotrexate on synovial inflammation by obtaining synovial biopsy samples before and after treatment in order to precisely define the role of methotrexate in the treatment of chronic CHIKV arthritis with the goal of advancing the field towards an evidence-based standard treatment.

PI_NAMEs: CHANG, AILEEN  (contact);FIRESTEIN, GARY S

PROGRAM_OFFICER_NAME: MAO, SU-YAU

PROJECT_TERMS: Affect;Aftercare;Alpha Virus;American;arm;Arthritis;ATAC-seq;Autoimmune Process;B-Lymphocytes;Biopsy;Biopsy Specimen;California;Cell Lineage;chemokine;chikungunya;chikungunya infection;Chikungunya virus;Chronic;Clinical;college;Colombia;Culicidae;cytokine;Degenerative polyarthritis;disability;Disease;Disease Outbreaks;Dose;efficacy evaluation;Evaluation;evidence base;Evidence based treatment;Folic Acid;follow-up;Gene Expression;Goals;Guidelines;Immune;Immunoassay;Immunohistochemistry;improved;Individual;Infection;Infiltration;Inflammatory;Janus kinase;kinase inhibitor;Leukocytes;Macrophage;Measures;Mediating;Methotrexate;novel;open label;Oral;Outcome;Pain;Pain Measurement;Pathogenicity;Pathologic;Patient Outcomes Assessments;patient subsets;Patients;Persons;Pharmaceutical Preparations;Placebos;primary endpoint;Proteins;Quality of life;Randomized;randomized placebo controlled trial;Randomized, Controlled Trials;Recommendation;Reporting;response;Rheumatoid Arthritis;Rheumatology;rituximab;Role;secondary endpoint;Severity of illness;single-cell RNA sequencing;standard care;Synovial Fluid;Synovitis;T-Cell Activation;T-Lymphocyte;Therapeutic;Therapeutic Agents;therapeutic target;therapeutically effective;Tissue Sample;Tissues;treatment guidelines;United States;Universities;Viral Arthritis;Work

PROJECT_TITLE: Methotrexate treatment of Arthritis caused by Chikungunya virus (MARCH): A randomized controlled trial of methotrexate versus placebo in the treatment of chronic arthritis after chikungunya infection

STUDY_SECTION: AMSC

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Clinical Trials Study Section [AMSC]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Mental Health;Networking and Information Technology R&D (NITRD);Pediatric;Pediatric Cancer;Physical Activity;Prevention;Rare Diseases;Rehabilitation;Telehealth

ORG_CITY: CHICAGO

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE The public health significance of this study lies in its potential to develop an improved understanding of how to effectively change adolescent and young adult cancer survivors' (AYACS) physical activity behavior. These findings could result in more effective, scalable physical activity interventions for this population, and ultimately, improve health outcomes and reduce healthcare costs associated with cancer recurrence, comorbidities, and premature death in AYACS.

PI_NAMEs: PHILLIPS, SIOBHAN MARIE (contact);VICTORSON, DAVID

PROGRAM_OFFICER_NAME: PERNA, FRANK

PROJECT_TERMS: Accelerometer;Address;Adherence;Adolescent and Young Adult;Adolescent and young adult cancer patients;Adverse effects;Age;American Cancer Society;Anxiety;Awareness;Behavior;behavior change;burden of illness;Cancer Burden;cancer care;Cancer Prognosis;cancer recurrence;Cancer Survivor;Cancer Survivorship;cancer type;Cellular Phone;Cessation of life;Child Care;Chronic Disease;Communities;comorbidity;cost;design;Development;digital health;Disease Outcome;disorder risk;Educational Intervention;Electronics;emotion regulation;Emotional;Engineering;evidence base;Exercise;exercise intervention;experience;experimental study;Fatigue;fitbit;follow-up;Funding;Gender;Goals;Health;Health behavior and outcomes;Health Benefit;Health Care Costs;Health Promotion;Height;improved;improved outcome;Individual;Intervention;intervention effect;Knowledge;Light;Malignant Neoplasms;Measures;Mediator;Mental Depression;Methodology;Methods;mHealth;mindfulness;Mindfulness Training;Morbidity - disease rate;mortality;multiphase optimization strategy;Outcome;peer;Physical activity;Population;Population Intervention;Posttraumatic growth;premature;programs;psychosocial;Psychosocial Factor;Public Health;Quality of life;Randomized;Recommendation;reduce symptoms;remote delivery;Research;Research Design;Research Methodology;Research Priority;Resources;response;Risk;Role;Schools;sedentary;Self Efficacy;self-compassion;Site Visit;Sleep;sleep quality;Social support;Survival Rate;Survivors;Symptom Burden;Technology;telephone coaching;Testing;Time;Treatment Side Effects;Treatment-Related Cancer;vigorous intensity;Work

PROJECT_TITLE: Optimization of a mHealth Physical Activity Promotion Intervention with Mindful Awareness for Adolescent and Young Adult Cancer Survivors


NIH_SPENDING_CATS: Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: LAWRENCE

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF KANSAS LAWRENCE

ORG_STATE: KS

PHR: PROJECT NARRATIVE The mammalian anti-viral response is partially regulated by post-translational modifications (PTMs) like phosphorylation. ADP-ribosylation is another type of PTM that is implicated in the anti-viral response, however little is known about how it hinders virus infections. The primary objective of this proposal is to determine how ADP-ribosylation inhibits virus replication and enhances the host immune response, with the goal of developing a better understanding of the mammalian anti-viral response that could lead to novel anti-viral therapies.

PI_NAMEs: FEHR, ANTHONY R (contact)

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TERMS: Address;Adenosine Diphosphate Ribose;ADP Ribose Transferases;ADP ribosylation;Affect;Anti-viral Response;Anti-viral Therapy;Automobile Driving;Biological Process;Biology;Cell Culture Techniques;Cells;Chiroptera;Communicable Diseases;Coronavirus;Family;Foundations;Goals;human disease;Hydrolase;Hypersensitivity;Immune response;immunoregulation;Impairment;Infection;innate immune mechanisms;Innate Immune Response;innovation;Interferons;Knock-out;Knowledge;Malignant Neoplasms;Mediating;Mission;Modeling;Murine hepatitis virus;mutant;National Institute of General Medical Sciences;novel;pathogenic virus;Pathway interactions;Phenotype;Phosphorylation;Poly(ADP-ribose) Polymerase Inhibitor;Post-Translational Protein Processing;Process;protein function;Proteins;Research;Research Personnel;response;RNA replication;Role;System;Togaviridae;Translations;Viral;Viral hepatitis;Viral Physiology;Virus;Virus Diseases;Virus Replication;Work

PROJECT_TITLE: Determining mechanisms of innate immune modulation by ADP-ribosylation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-T(55)R]


NIH_SPENDING_CATS: Cancer;Clinical Research;Digestive Diseases;Pancreatic Cancer;Prevention;Rare Diseases

ORG_CITY: OMAHA

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: Project Narrative This proposal to continue in the Pancreatic Cancer Detection Consortium will further build and enhance our biospecimen resource that collects longitudinal blood samples on patients at risk of developing pancreatic cancer and unique tissue resources that include rare pancreatic premalignant lesions. We also propose to enhance our discovery and validation of blood-based and imaging-based biomarkers that have the potential to detect and differentiate at the earliest possible stages pancreatic lesions that are likely to progress to cancer.

PI_NAMEs: HOLLINGSWORTH, MICHAEL A. (contact)

PROGRAM_OFFICER_NAME: YOUNG, MATTHEW R

PROJECT_TERMS: Address;Affect;anti-cancer research;Antibodies;Autopsy;Award;Benign;Biological;Biological Markers;Biology;biomarker development;biomarker discovery;biomarker validation;Blood;Blood specimen;cancer biomarkers;Cancer Detection;cancer diagnosis;cancer risk;Characteristics;chronic pancreatitis;circulating biomarkers;Clinical;clinical application;Clinical Data;clinical diagnosis;cohort;Collection;Cystic Lesion;Diabetes Mellitus;Diagnostic;Disease;Disease Progression;Doctor of Philosophy;early detection biomarkers;Early Detection Research Network;Early Diagnosis;Enrollment;Etiology;Evaluation;exosome;Female;Foundations;Freezing;Frequencies;Future;Germ-Line Mutation;Glycoproteins;Grant;Human;human tissue;imaging biomarker;imaging modality;Immunohistochemistry;improved;individual patient;Inherited;interest;Intuition;Laboratories;Laboratory Research;Lesion;male;Malignant - descriptor;Malignant neoplasm of pancreas;Malignant Neoplasms;Measures;Medical Oncologist;medical schools;member;Methods;mouse model;Mucins;Mutation;Neoplasm Metastasis;novel;novel marker;Operative Surgical Procedures;Organoids;Pancreas;pancreatic cancer model;Pancreatic cystic neoplasia;patient population;Patient Recruitments;Patients;Performance;Phase;Plasma;premalignant;Principal Investigator;Procedures;professor;prospective;Proteins;Research;Research Personnel;Resources;Risk;sample collection;Sampling;Screening for cancer;Sensitivity and Specificity;Serum;Specimen;Target Populations;Time;Tissue Banks;tissue resource;Tissue Sample;Tissues;translational cancer research;tumor microenvironment;tumor progression;Validation

PROJECT_TITLE: Pancreatic Cancer Detection Consortium


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Cancer;Cancer Genomics;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Prostate Cancer;Rural Health;Social Determinants of Health;Urologic Diseases

ORG_CITY: SCOTTSDALE

ORG_NAME: MAYO CLINIC ARIZONA

PHR: Project Narrative With this greater certainty regarding prognosis, men with localized prostate cancer are now equipped with to make better treatment planning decisions. This project is designed to investigate the understanding of prognostic genetic technology and patient-caregiver communication in African American and rural White men with localized prostate cancer.

PI_NAMEs: COBRAN, EWAN KEMAR (contact)

PROGRAM_OFFICER_NAME: WALI, ANIL

PROJECT_TERMS: Address;Adoption;Adult;African American;Alabama;American;Biochemical;Cancer Biology;cancer education;cancer health disparity;Cancer Prognosis;Caregivers;Communication;Communities;community engaged research;Comprehension;Data Analyses;Death Rate;design;Diagnosis;Diffusion of Innovation;directed attention;Disadvantaged;Disparity;Education;Educational Status;Educational workshop;efficacy evaluation;Ethnic Population;evidence based guidelines;Focus Groups;Funding;Genes;Genetic;genetic technology;genetic testing;genome sciences;Genomic medicine;Genomics;Geographic Locations;Goals;Group Interviews;Health Benefit;health disparity;health literacy;Health Sciences;Impairment;improved;Incidence;innovation;Investments;Knowledge;literacy;Literature;Louisiana;low health literacy;Low income;Low Income Population;Low Literacy Population;low socioeconomic status;Malignant neoplasm of prostate;Maryland;mathematical ability;men;Mentors;Methods;Microarray Analysis;Minority;Mission;Mississippi;mortality;mRNA Expression;National Comprehensive Cancer Network;National Human Genome Research Institute;Neoplasm Metastasis;next generation sequencing;North Carolina;novel;novel strategies;Nurses;oncotype;Participant;Patients;Prognosis;prognostic;prognostic value;programs;Prostate Cancer therapy;Prostatectomy;Public Health;Race;Radiation;randomized, controlled study;Recommendation;Recurrence;Research;Risk;Rural;Rural Population;skills;South Carolina;Structure;Technology;theories;Time;Tissues;Training;Treatment outcome;treatment planning;United States;United States National Institutes of Health;Virginia

PROJECT_TITLE: Genetic Literacy and Patient-Caregiver Communication of Prognostic Genetic Technology for Localized Prostate Cancer

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Neurosciences;Pediatric;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_DEPT: ORTHOPEDICS

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PHR: PROJECT NARRATIVE As we have previously reported, skeletal sensory nerve fibers critically regulate multiple aspects of bone morphogenesis, response to mechanical load, and bone repair. Yet, the molecular underpinnings that underlie these phenotypic consequences are only now becoming clear. Here, we will precisely define how TrkA+ skeletal sensory nerve axons spatially approximate osteogenic precursors in the developing bone in order to induce skeletal stem cell expansion and coordinately inhibit their differentiation.

PI_NAMEs: CLEMENS, THOMAS L (contact);JAMES, AARON W

PROGRAM_OFFICER_NAME: GHIM, MELISSA M

PROJECT_TERMS: Acute;adenovirus mediated delivery;afferent nerve;Afferent Neurons;angiogenesis;Area;Axon;Blood Vessels;bone;Bone Diseases;bone repair;Calvaria;cell behavior;Cell Differentiation process;Cell Lineage;Cell Proliferation;Cells;Cephalic;Coculture Techniques;Collaborations;cranium;Data;Dermal;Femur;Fiber;Follistatin;Funding;gene network;genetic signature;Genetic Transcription;Genomics;Growth;Histologic;Home;Homeostasis;Human;Impairment;In Vitro;Infiltration;inhibitor;insight;Joint structure of suture of skull;Knock-in Mouse;Legal patent;limb regeneration;Location;Maps;mechanical load;Mediating;Mesenchymal;Mesenchymal Stem Cells;Methods;Microfluidics;Modeling;Molecular;Monitor;Morphogenesis;Mus;Natural regeneration;Nerve;Nerve Fibers;Nerve Growth Factors;nerve supply;neural;Neurons;neuropathology;neurotropic;Nociception;Osteogenesis;osteogenic;osteoprogenitor cell;Pattern;Peripheral;Phenocopy;Phenotype;Phosphotransferases;Play;premature;preservation;programs;Proliferating;receptor;Recombinants;Regulation;repaired;Reporter;Reporting;response;Role;Scaphycephaly;Sensory;Signal Pathway;Signal Transduction;skeletal;Skeletal Development;skeletal stem cell;spatiotemporal;stem cell differentiation;stem cell expansion;stem cell proliferation;stem cells;Surgical sutures;Techniques;Time;time interval;tool;transcriptomics;Transgenic Organisms;Tropomyosin;Undifferentiated;Up-Regulation;Vascularization

PROJECT_TITLE: Neuronal Regulation of Skeletal Development and Repair

STUDY_SECTION: SBSR

STUDY_SECTION_NAME: Skeletal Biology Structure and Regeneration Study Section[SBSR]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cancer;Hematology;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

ORG_CITY: Eagleville

ORG_NAME: SHIP OF THESEUS, LLC

ORG_STATE: PA

PHR: PROJECT NARRATIVE Hematopoietic stem cell (HSC) transplants are used to treat certain cancers of the blood and bone marrow. Diseased bone marrow is removed and replaced with healthy cells, but patients are at high risk for infection and other life-threatening inflammatory conditions until the healthy cells expand enough to restart the immune system. Ship of Theseus is developing therapeutic strategy to shorten this window of risk and improve patient outcomes by developing a novel and safe drug, HOXB4(m), that improves HSC expansion within the patient.

PI_NAMEs: ELSER, JEREMY A (contact)

PROGRAM_OFFICER_NAME: AGRAWAL, NITIN

PROJECT_TERMS: Acceleration;Adverse effects;Adverse event;Aftercare;ANXA5 gene;Apoptosis;Apoptotic;Biological;Biological Assay;Blood;Bone Marrow;Bone Marrow Diseases;Bone Marrow Transplantation;candidate identification;candidate selection;CD34 gene;Cell Nucleus;Cell Transplantation;Cells;chemotherapy;Chemotherapy and/or radiation;Chimeric Proteins;Chimerism;Clinic;Clinical;clinical investigation;Clinical Trials;comparison control;Complex;conditioning;Consumption;cost;cytotoxicity;Data;Disease;Dose;Dyes;efficacy evaluation;efficacy study;Engraftment;Excision;experience;Exploratory/Developmental Grants Phase II;Exposure to;Female;Fluorescence Microscopy;Future;Gel;Genetic;Goals;Half-Life;Hela Cells;Hematopoietic;Hematopoietic Neoplasms;hematopoietic stem cell expansion;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;high risk;Homeodomain Proteins;Hospitalization;Hour;Human;Immune system;Immunodeficient Mouse;improved;In Vitro;in vivo;Infection;infection risk;Inflammatory;innovation;Inpatients;Intravenous infusion procedures;Lead;lead candidate;Legal patent;Libraries;Life;male;Malignant Bone Marrow Neoplasm;man;manufacture;Measures;Methodology;Methods;Modeling;Monitor;Mucositis;Mus;mutant;Myelogenous;Myeloproliferative disease;Necrosis;Neutropenia;novel;Nuclear;overexpression;Patient-Focused Outcomes;Patients;Penetration;Peptides;peripheral blood;Pharmaceutical Preparations;Phase;post-transplant;pre-clinical;preclinical development;Predisposition;Proliferating;Proteins;reconstitution;Recovery;Resistance;Risk;Safety;safety study;Scanning;screening;Site;Source;Stains;stem cell expansion;stem cell function;System;Therapeutic;Time;Toxic effect;Toxicology;transcription factor;Transplant Recipients;Transplantation;Transplantation Conditioning;uptake

PROJECT_TITLE: Preclinical development of a nuclear-targeting biologic that safely increases stem cell expansion in vivo to accelerate recovery from neutropenia after chemotherapy and bone marrow transplant


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Autism;Brain Disorders;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: NEW YORK

ORG_DEPT: NEUROSCIENCES

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: PROJECT NARRATIVE One in 100 children worldwide are diagnosed with autism spectrum disorder (ASD), with diverse symptoms such as social impairment, communication difficulties, and restrictive or repetitive behaviors beginning in early childhood. Thousands of non-coding de novo variants (DNVs) have been identified in individuals with autism, and this proposal will investigate whether DNVs found in human neuronal enhancers alter their regulatory activity and influence expression of downstream gene networks previously implicated in ASD. Deciphering the genetic contributions underlying ASD will enable more thorough diagnostic tools and inform more precise and effective care options.

PI_NAMEs: WILLIAMS, SARAH ELIZABETH (contact)

PROGRAM_OFFICER_NAME: VAN'T VEER, ASHLEE VICTORIA

PROJECT_TERMS: Advocate;Affect;autism spectrum disorder;Basic Science;Binding;Biological Assay;Biology;career;Caring;cell type;Child;Chromatin;Clinical Trials;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;Communication difficulty;Complex;Copy Number Polymorphism;Data;Data Set;de novo mutation;Dependence;design;Development;Diagnosis;diagnostic tool;early childhood;Engineering;Enhancers;Epigenetic Process;Etiology;excitatory neuron;exome sequencing;experimental study;functional genomics;Funding;Future Generations;Gene Expression;gene network;gene regulatory network;Gene Targeting;Genes;Genetic;genetic architecture;Genetic Transcription;Genetic Variation;Genome;Genomics;Glutamates;Goals;Guide RNA;Home;Human;human pluripotent stem cell;human stem cell-derived;Impairment;In Vitro;Individual;individuals with autism spectrum disorder;inhibitory neuron;innovation;Interdisciplinary Study;Laboratory Research;Maps;medical schools;Membrane;Mental disorders;mental health education;Mentors;Mentorship;Modeling;Molecular;neurodevelopment;Neurodevelopmental Disorder;Neurons;Neurosciences;Open Reading Frames;Pathway interactions;Point Mutation;professor;promoter;Psychiatry;psychogenetics;Regulatory Element;repetitive behavior;Reporter;Research;Rest;risk variant;Role;Scientist;Siblings;single-cell RNA sequencing;skills;social;stem cells;Symptoms;Techniques;therapeutically effective;Training;transcription factor;transcriptomics;United States National Institutes of Health;Untranslated RNA;Validation;Variant;Work

PROJECT_TITLE: Cell-type specific and activity-dependent characterization of non-coding autism de novo variants in human stem cell-derived neurons


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Pediatric;Prevention;Primary Health Care;Social Determinants of Health;Telehealth

ORG_CITY: Chicago

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: Project Narrative  Millions of American teens do not receive appropriate mental health care; teens from underserved populations face the greatest barriers. The proposed research will harness existing digital mental health technologies, such as computerized assessments and mobile health [mHealth] apps, to develop a screening and treatment system which we will then implement and evaluate for engagement outcomes in a pediatric primary care clinic on the West Side of Chicago. The knowledge gained from this project will demonstrate the real-world engagement, acceptability, access, and use of these digital mental health technologies to decrease pediatric mental health disparities.

PI_NAMEs: STILES-SHIELDS, COLLEEN  (contact)

PROGRAM_OFFICER_NAME: SIMS, BELINDA ENITA

PROJECT_TERMS: Acceleration;Address;American;Appointment;behavioral health;brief intervention;career;career development;Caring;Chicago;Child;Child health care;child services;Childhood;Clinical;clinical care;Collaborations;community intervention;computerized;Crime;Data;Decision Making;design;Detection;Development;Development Plans;Diagnosis;digital mental health;Disease;dissemination science;Educational Materials;Educational workshop;Environment;Ethics;ethnic minority;Ethnic Origin;Evaluation;evidence base;Evidence based treatment;Face;Family;feasibility trial;Feedback;Future;Goals;healing;Health;health care service;health disparity;health inequalities;Health Services Accessibility;Health Technology;implementation framework;implementation outcomes;implementation science;improved;Individual;innovation;Institution;Insurance Coverage;Intervention;Interview;Investments;Knowledge;Language;Link;low socioeconomic status;Medical;Mental disorders;Mental Health;Mental Health Services;Mentors;Mentorship;Methods;mHealth;Mind;Mobile Health Application;Modeling;National Institute of Mental Health;Observational Study;organizational readiness;Outcome;Parents;Patients;pediatrician;Pediatrics;Perception;Population;Preparation;Primary Care;primary care clinic;primary care setting;Privacy;Process;Productivity;programs;psychoeducation;Public Health;Race;racial minority;Randomized;randomized trial;Recommendation;remediation;Reporting;Research;research and development;Risk;satisfaction;Scientist;screening;service delivery;Service setting;Sexual and Gender Minorities;Side;skills;social stigma;Symptoms;System;technology intervention;Teenagers;Testing;Training;Transportation;Underserved Population;uptake;usability;user centered design;Well Child Visits;Youth

PROJECT_TITLE: Supporting Mental Health in Underserved Youth: Engagement with Digital Mental Health Technologies in Pediatric Primary Care

STUDY_SECTION: SERV

STUDY_SECTION_NAME: Mental Health Services Study Section[SERV]


NIH_SPENDING_CATS: Biotechnology;Cancer;Lung;Lung Cancer

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: NARRATIVE Distant metastases are responsible for the vast majority of cancer deaths, but there is currently a lack of effective anti-metastatic therapies. Collective invasion, in which cohesive packs of cancer cells travel together, is a major mode of metastasis observed in patients across solid tumor types. A better understanding of the mechanisms underlying the cooperation between heterogeneous subpopulations that comprise these invasive packs could lead to new targeted therapies for the prevention and treatment of cancer metastasis in patients.

PI_NAMEs: MOUW, JANNA K (contact)

PROGRAM_OFFICER_NAME: GRIL, BRUNILDE M

PROJECT_TERMS: anti-cancer research;Biological;Biomedical Engineering;Cancer Biology;cancer cell;Cancer Patient;cancer therapy;Cells;Cellular biology;Cessation of life;Communication;Confocal Microscopy;Dedications;Distant Metastasis;Endothelium;Engineering;experience;Fluorescence-Activated Cell Sorting;Funding;Genomics;Goals;Grant;Heterogeneity;In Vitro;in vivo;insight;Institution;Invaded;Journals;Laboratories;Lead;Legal patent;Malignant neoplasm of lung;Malignant Neoplasms;Mechanics;Medicine;migration;mimicry;Molecular;multidisciplinary;Nature;Neoplasm Metastasis;new therapeutic target;Non-Small-Cell Lung Carcinoma;Patients;Population;Prevention therapy;programs;Proliferating;Publishing;Research;Role;Signal Transduction;Solid Neoplasm;spatiotemporal;targeted treatment;Techniques;Testing;Training;translational impact;Travel;tumor;tumor progression;Universities;Work

PROJECT_TITLE: Deconstructing cellular heterogeneity and subpopulation cooperation in non-small cell lung cancer metastasis


NIH_SPENDING_CATS: Genetics

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative The goal of this project is to understand the roles of post-abscission midbodies (MBs). We already have shown that these MBs are internalized by neighboring cells where they form a novel signaling organelles known as MBsomes. Importantly, it was suggested that the accumulation of intra-cellular MBsomes regulates cell proliferation and differentiation. Thus, completion of this project will identify and characterize the molecular machinery governing the internalization and formation of MBsomes, as well as will define signaling pathways that mediate MBsome function.

PI_NAMEs: PREKERIS, RYTIS  (contact);RAPOSO, GRACA GRACA

PROGRAM_OFFICER_NAME: MILLER, RITA K

PROJECT_TERMS: 3' Untranslated Regions;Apical;Binding Proteins;Biological Assay;cancer cell;Cell Cycle Stage;Cell Differentiation process;Cell division;Cell Proliferation;Cells;CENP-E protein;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;CRISPR screen;Cues;Cytokinesis;Data;daughter cell;Diffusion;Electron Microscopy;Elements;Excision;Extracellular Space;Foundations;Goals;Image;Immunofluorescence Immunologic;Interphase;Interphase Cell;Knowledge;Laboratories;light microscopy;Location;Maps;Mediating;member;Messenger RNA;Microscopy;Microtubules;Mitosis;Mitotic;Molecular;Mothers;Mutagenesis;Neurites;novel;Organelles;physical separation;Play;postmitotic;Process;Proliferating;Proteins;Proteomics;Protocols documentation;recruit;Resolution;RNA-Binding Proteins;Role;Side;Signal Pathway;Signal Transduction;stem cells;Stimulation of Cell Proliferation;Structure;Testing;Thinness;transcriptome sequencing;Translating;Translations;Untranslated Regions;uptake

PROJECT_TITLE: The roles of midbody associated mRNAs in regulating cell proliferation and differentiation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-C(02)M]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Asthma;Chronic Obstructive Pulmonary Disease;Clinical Research;Health Effects of Indoor Air Pollution;Lung;Pediatric;Prevention;Pulmonary Fibrosis

ORG_DEPT: PEDIATRICS

PHR: PROJECT NARRATIVE Children with asthma are at risk for abnormal lung function growth, lower lung function in adulthood, and adult obstructive lung disease, which are associated with increased mortality risk. The project will examine the effects of indoor allergen exposure and allergen reduction on long-term lung function growth and explore their effects on biomarkers of pulmonary fibrosis and remodeling. This work is designed to test the hypothesis that allergen exposure reduction improves lung function trajectory among children with allergic asthma, which, if true, would have a major public health impact.

PI_NAMEs: GRANT, TORIE  (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Acids;Address;Adult;Affect;Allergens;Allergic Disease;Arachidonic Acids;Asthma;Biological Markers;Biological Specimen Banks;biomarker discovery;biomarker driven;Biometry;Bronchodilator Agents;career;career development;Characteristics;Child;Childhood;Childhood Asthma;Chronic Obstructive Pulmonary Disease;Clinical;clinical effect;Clinical Investigator;cohort;Data;Data Analyses;Data Collection;design;Development Plans;Dinoprostone;Disease;Disease Progression;Doctor of Philosophy;Education;Enrollment;Environmental Exposure;Environmental Health;Environmental Risk Factor;Epidemiology;experience;Exposure to;Extrinsic asthma;Fibrosis;Foundations;functional decline;Grant;Growth;hepatoma-derived growth factor;Home;Immunologist;Impairment;improved;indoor allergen;Inflammatory;insight;Insulin-Like Growth-Factor-Binding Proteins;Internist;Interstitial Collagenase;Intervention;Intervention Trial;Knowledge;Leukotriene B4;Leukotriene C4;Link;lipid mediator;lipoxin A4;Long-Term Effects;Lung;Lung Diseases;Mass Spectrum Analysis;Measures;medical schools;Medicine;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;MMP2 gene;MMP9 gene;modifiable risk;Morbidity - disease rate;mortality risk;mouse allergen;multiplex assay;Mus;novel;Observational Study;Obstructive Lung Diseases;Outcome;Parents;Participant;pediatrician;Pediatrics;periostin;Pharmaceutical Preparations;Physicians;Plasminogen Activator Inhibitor 1;professor;programs;Prospective cohort;Public Health;Public Health Schools;Pulmonary Fibrosis;pulmonary function;pulmonary function decline;Pulmonary Function Test/Forced Expiratory Volume 1;Pulmonary function tests;Reporting;Research;Risk;Risk Factors;Risk Reduction;Role;School-Age Population;Scientist;Serum;skills;Spirometry;study population;success;targeted biomarker;Testing;Tobacco;Training;trend;Universities;Vascular Endothelial Growth Factors;Wood material;Work

PROJECT_TITLE: Allergen Exposure Reduction as a Disease-Modifying Strategy in Allergen-Sensitized Children with Asthma

STUDY_SECTION: AITC

STUDY_SECTION_NAME: Allergy, Immunology, and Transplantation Research Committee[AITC]


ADMINISTERING_IC: LM

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Data Science

ORG_CITY: NASHVILLE

ORG_DEPT: MISCELLANEOUS

ORG_NAME: MEHARRY MEDICAL COLLEGE

ORG_STATE: TN

PHR: Project Narrative Fisk University, Meharry Medical College, and Vanderbilt University Medical Center propose a novel collaborative program to engage 30 diverse undergraduate and graduate students in meaningful biomedical informatics and biomedical data experiences summer research experiences. This five-year program will also reach an additional 50 students from HBCUs as part of online outreach activities and develop a sustainable biomedical informatics and biomedical data science ecosystem, which will support educational and research collaboration among trainees and faculty at these three institutions. .

PI_NAMEs: MHLANGA, FORTUNE  (contact);QIAN, LEI ;UNERTL, KIM M

PROJECT_TERMS: Academic Medical Centers;Applied Research;Award;biomedical data science;biomedical informatics;career;Career Choice;Collaborations;Computational Science;computer science;Data;Data Science;Development;Ecosystem;Education;Educational Activities;Educational Curriculum;Ensure;equity, diversity, and inclusion;experience;Faculty;faculty research;Foundations;Future;graduate student;Grant;Historically Black Colleges and Universities;improved;Institution;Instruction;Joints;medical schools;Mentors;Methodology;Methods;novel;outreach;Process;Program Evaluation;programs;Research;research and development;Research Project Grants;responsible research conduct;Schools;Series;skill acquisition;student participation;Student recruitment;Students;summer program;summer research;Talents;tool;training opportunity;Trust;undergraduate student;Underrepresented Populations;Universities

PROJECT_TITLE: The Fisk-Meharry-Vanderbilt Biomedical Informatics Ecosystem to Support Diverse Students in Data Science


NIH_SPENDING_CATS: Atherosclerosis;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Heart Disease;Infectious Diseases;Obesity;Prevention

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: Project Narrative: This study will assess whether a novel class of drugs (dual CCR2/CCR5 antagonists), can be used to improve vascular and metabolic health in people living with HIV. The study will determine if the intervention reduces arterial inflammation, (a primary disease-causing feature of plaque in the arteries), reduces adipose tissue inflammation, and improves insulin resistance (the driver of diabetes). The study will be performed across multiple sites in the United States, in collaboration with an established AIDS research network.

PI_NAMEs: LO, JANET  (contact);TAWAKOL, AHMED A

PROGRAM_OFFICER_NAME: HASAN, AHMED A  K

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Adipose tissue;Adult;AIDS clinical trial group;antagonist;antiretroviral therapy;Applications Grants;Arterial Intimas;Arteries;Atherosclerosis;Binding;Biological;Biological Availability;Biological Markers;Blood Vessels;cardiovascular disorder risk;CCL2 gene;CCR5 gene;Cell surface;Cells;chemokine;chemokine receptor;circulating biomarkers;Clinical Trials;Collaborations;Coronary heart disease;coronary plaque;cytokine;Development;Diabetes Mellitus;Disease;Double-Blind Method;Dyslipidemias;effective intervention;Gene Expression;Genes;Health;HIV;HIV Infections;HIV-1;Homing;Immune;immune activation;Immune Targeting;improved;in vivo;Individual;Infiltration;Inflammation;Inflammatory;inflammatory marker;Infrastructure;inhibitor;Insulin Resistance;insulin sensitivity;Intervention;Laboratories;Ligands;lipid biosynthesis;Macrophage;Mature T-Lymphocyte;Measures;Mediating;men;Metabolic;Metabolic Diseases;monocyte;nonalcoholic steatohepatitis;novel;novel drug class;Obesity;Oral;Pathogenesis;patient population;Patients;Persons;PET/CT scan;Placebo Control;Placebos;Population;prospective;Randomized;randomized trial;randomized, clinical trials;receptor;recruit;Research;Research Personnel;Residual state;Risk;RNA;Signal Transduction;Site;T-Cell Activation;T-Lymphocyte;Testing;therapeutic candidate;therapeutically effective;Tissues;Tunica Intima;United States;Viral Physiology;Visceral;Woman;X-Ray Computed Tomography

PROJECT_TITLE: Reducing Arterial Inflammation and Improving Metabolic Health by Dual CCR2 and CCR5 Antagonism in People Living with HIV

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


NIH_SPENDING_CATS: Cancer;Genetics;Lung;Lung Cancer

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: Lung cancer remains one of the deadliest malignancies in the United States. Metastasis is the main cause of lung cancer patient death. Our application focuses on a novel mechanism regulating lung cancer metastasis and the role for autophagy related gene in this process. Our studies are expected to not only improve our understanding of the ways in which lung cancer metastasizes, but also form the basis for future developing novel therapeutic strategies for this deadly disease.

PI_NAMEs: MC NIVEN, MARK A. (contact)

PROGRAM_OFFICER_NAME: AULT, GRACE S

PROJECT_TERMS: Ablation;American;Autophagocytosis;Autophagosome;Binding;Biological;Biology;Cancer Etiology;Cancer Patient;Cause of Death;Cessation of life;Data;Data Set;Disease;effective therapy;Future;Gene Expression;gene repression;gene-editing approach;Genes;Genetic Transcription;Genetically Engineered Mouse;Goals;Growth;improved;insight;Invaded;Investigation;Malignant neoplasm of lung;Malignant Neoplasms;Mediating;Membrane;migration;Mitochondria;Neoplasm Metastasis;novel;novel therapeutic intervention;Play;Process;Promoter Regions;Public Health;Regulation;Repression;Role;statistics;Testing;The Cancer Genome Atlas;Therapeutic;transcription factor;translational potential;Tumor Suppressor Proteins;United States;World Health Organization

PROJECT_TITLE: Investigation of a mitochondria-associated metastasis regulatory mechanism

STUDY_SECTION: TPM

STUDY_SECTION_NAME: Tumor Progression and Metastasis Study Section[TPM]


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Endocrine Disruptors;Pediatric;Prevention

ORG_CITY: Fort Lauderdale-Davie

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: NOVA SOUTHEASTERN UNIVERSITY

PHR: Project Narrative Organofluorine compounds, PFAS (per- and polyfluoroalkyl substances) have generated increased public attention due to their potential health hazard and widespread presence in the environment. We will identify possible PFAS toxicological effects on tooth development in a mouse model. Once PFAS toxicological effects are identified in tooth formation, PFAS could be considered as a possible causative factor for cryptogenic abnormalities in dentinogenesis.

PI_NAMEs: SUZUKI, MAIKO  (contact)

PROGRAM_OFFICER_NAME: THIRUMANGALATHU, SHOBA

PROJECT_TERMS: Acquired Dental Fluorosis;Adverse effects;Affect;alcohol effect;Alcohols;Ameloblasts;Amelogenesis;analytical method;Animal Disease Models;Animal Model;Animals;Area;Attention;career;career development;Cell Line;Cells;Child;Childhood;Cleft Palate;Collaborations;craniofacial;Craniofacial Abnormalities;Data;Defect;Deformity;density;Dental;Dental caries;Dental Enamel;Dentinogenesis;Development;DNA Damage;drinking water;Environment;environmental chemistry;Environmental Epidemiology;Environmental Health;Environmental Pollutants;Environmental Risk Factor;Environmental Science;epidemiology study;Etiology;experience;Exposure to;Faculty;Fishes;Fluorescence;Fluorides;Functional disorder;Funding;Goals;Hazardous Chemicals;Health;Health Hazards;Histologic;Human;Immune system;in vivo;Incidence;Incisor;Independent Scientist Award;Induction of Apoptosis;Industry;Inhibition of Cell Proliferation;Ions;Knowledge;Laboratory Animals;Learning;Light;malformation;malignant mouth neoplasm;manufacture;men's group;microCT;mid-career faculty;Minerals;Mitochondria;Modeling;Molecular;Molecular Biology;mouse model;Mouth Diseases;Mus;Nanostructures;novel;Odontogenesis;oral biology;Organism;Outcome;perfluorooctanoic acid;Periodontitis;Phenotype;Physiology;pollutant;Poly-fluoroalkyl substances;prenatal;Prevalence;Preventive;Productivity;reproductive;Research;Research Personnel;Research Project Grants;Research Training;Rodent;Scanning Electron Microscopy;Science;skeletal tissue;skills;Stains;Structure;Testing;Therapeutic;Time;Tooth structure;Toxic Environmental Substances;Toxicology;Training;tumor;United States;Water;Zebrafish

PROJECT_TITLE: Health Effects of the Fluorinated Pollutants; PFAS on Enamel Development

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR(01)]


ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative Lysosomal damage is widely involved in many human diseases and can be triggered by various cellular stressors. Successful completion of this project will provide in-depth mechanistic understanding of how lipid remodeling contributes to lysosomal quality control and cellular homeostasis. These findings are expected to open new avenues to therapeutically intervene a wide array of lysosome-related diseases.

PI_NAMEs: TAN, XIAOJUN  (contact)

PROGRAM_OFFICER_NAME: STOKES, KALYNDA K

PROJECT_TERMS: 1-Phosphatidylinositol 4-Kinase;Aging;Cardiovascular Diseases;Cell Death;cell growth;Cell Membrane Permeability;Cell model;Cell Physiology;Cellular Stress;Chemicals;Cholesterol;design;Disease;Endoplasmic Reticulum;Family member;FDA approved;Functional disorder;Homeostasis;Human;human disease;improved;interest;lipid transport;lipidomics;Lipids;Lysosomal Storage Diseases;Lysosomes;Mediating;Membrane;Nerve Degeneration;Nutrient;oxysterol binding protein;Pathway interactions;phosphatidylinositol 4-phosphate;Phosphatidylinositols;Phosphatidylserines;Play;Production;Protein Family;Proteins;Proteomics;Quality Control;recruit;Recycling;repaired;response;Role;small molecule;small molecule libraries;stressor;Therapeutic

PROJECT_TITLE: Lysosomal quality control through lipid remodeling

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


NIH_SPENDING_CATS: Cancer

ORG_CITY: LA JOLLA

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative My research has focused on the overarching theme of how cell surface receptors mediate an invasive phenotype by promoting adaptations that support cell survival in the face of stress. While this is a critical component of physiological remodeling processes such as angiogenesis, tumor cells often hijack these same pathways to promote metastasis and tumor progression. Throughout my career, I have emphasized the combination of basic and translational cancer research which has resulted in one cancer drug recently approved by the FDA and a second drug that has successfully completed Phase III trials.

PI_NAMEs: CHERESH, DAVID A (contact)

PROGRAM_OFFICER_NAME: WATSON, JOANNA M

PROJECT_TERMS: angiogenesis;Antineoplastic Agents;Basic Cancer Research;Behavior;cancer therapy;career;Cell surface;Cell Surface Receptors;Cell Survival;Cells;Cellular Stress;Cues;Drug resistance;Endothelial Cells;Evolution;FDA approved;Genetic;Goals;Hypoxia;Individual;Integrin alphaV;Integrin alphaVbeta3;Integrins;Lead;Malignant Neoplasms;Mediating;Neoplasm Metastasis;neoplastic cell;new therapeutic target;nutrient deprivation;Pathway interactions;Pharmaceutical Preparations;phase III trial;Phenotype;Physiological;prevent;Process;programs;Research;response;stem;Stress;stress tolerance;Supporting Cell;Therapeutic;translational cancer research;tumor;tumor microenvironment;tumor progression

PROJECT_TITLE: Attacking stress tolerance in cancer


NIH_SPENDING_CATS: Asthma;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: AUSTIN

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

ORG_STATE: TX

PHR: Project Narrative Asma Guardián will be among the first Mexican-American-tailored, community-based asthma intervention that is designed to scale to the state-level, can be launched by any entity and designed to empower families to engage in three actions that are known to improve asthma outcomes. We will pilot test Asma Guardián and will have multi-dimensional data on engagement and process measures as well as an estimate of its effects on asthma outcomes, including asthma control and exacerbations. Completion of the proposed aims will strongly position the investigator team to successfully plan and execute a state-wide trial of Asma Guardián.

PI_NAMEs: MATSUI, ELIZABETH C. (contact)

PROGRAM_OFFICER_NAME: FREEMER, MICHELLE M

PROJECT_TERMS: Acute;Advocacy;Affect;Airborne Particulate Matter;Allergens;Asthma;Behavioral Sciences;Belief;Black race;Caregivers;Caring;Child;Clinical;Clinics and Hospitals;Communication;communication behavior;Communities;community advisory board;Community Health Aides;Community Services;design;Development;Dust;Education;education access;educational atmosphere;Educational Materials;efficacy trial;empowerment;Environment;environmental intervention;Face;Family;family support;Focus Groups;Foundations;geographic barrier;Geography;Goals;Health behavior;health care availability;health care quality;Home;Home environment;Hospitalization;Housing;improved;indoor exposure;Intervention;Language;Latinx;Letters;Measures;Mexican Americans;Modeling;Morbidity - disease rate;multidimensional data;online community;Only Child;Outcome;Parents;Pharmacy facility;pilot test;pilot trial;Population;Positioning Attribute;Prevalence;Process Measure;prototype;Randomized;randomized, clinical trials;Research;Research Personnel;Risk;Self Management;Services;Shapes;skills;socioeconomics;Specialist;Testing;Texas;Time;tool;Travel;Visit;web platform;Work

PROJECT_TITLE: A culturally tailored, scalable asthma intervention for Mexican American children

STUDY_SECTION: SSPT

STUDY_SECTION_NAME: NHLBI Single-Site and Pilot Clinical Trials Study Section[SSPT(JA)]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Neurosciences;Rare Diseases

PHR: Project Narrative There are several factors that likely contribute to healthy esophageal muscular function. Yet, our understanding of diseases of the esophageal muscle has thus far been limited to mechanisms of neurally-mediated contraction and relaxation of the esophageal muscle. The goal of this clinical trial is to study the impact of the biomechanical properties such as muscle fibrosis towards the impairments in muscle function in achalasia with the goal of identifying novel treatment targets and improving patient outcomes.

PI_NAMEs: JAIN, ANAND SAGAR (contact)

PROGRAM_OFFICER_NAME: OSGANIAN, VOULA

PROJECT_TERMS: Achalasia;Actins;Apoptosis;Atropine;Biological;Biology;Biomechanics;Biometry;California;career;career development;Cell Communication;Cell Culture Techniques;Cell Degranulation;Chymase;Clinical Investigator;Clinical Research;clinical training;Clinical Trials;Coculture Techniques;Collagen;cytokine;Data;Data Analyses;Deformity;Deglutition;Development;Digestive System Disorders;Dilatation - action;Disease;Elements;Enteral;Esophageal Diseases;Esophageal motility disorders;Esophagus;experimental study;Extracellular Matrix;Fibroblasts;Fibronectins;Fibrosis;Functional disorder;Functional impairment;Funding;Future;Ganglia;Goals;Grant;IgE Receptors;imaging probe;Impairment;improved;In Vitro;in vivo;Inferior esophageal sphincter structure;inhibitory neuron;Laboratories;Learning;Machine Learning;mast cell;Master of Science;Measurement;Measures;Mechanics;Mediating;medical schools;Medicine;Mentors;Mentorship;Molecular;Molecular Biology;molecular targeted therapies;Muscle;Muscle function;Myenteric Plexus;Myopathy;Natural History;Nerve Degeneration;neural;neuromechanism;Neurons;new technology;Nitric Oxide Donors;novel;Pathogenesis;Patient-Focused Outcomes;Patients;Pharmacology;Physiological;Physiology;Play;Property;Proto-Oncogene Protein c-kit;Recurrence;Recurrent disease;Relaxation;Research Personnel;Resources;response;Role;Scientist;Secondary to;Smooth Muscle;Smooth Muscle Myocytes;Sphincter;Stains;Techniques;Testing;Time;Tissues;Training;translational scientist;Trichrome stain method;Tryptase;Universities;Variant;Work

PROJECT_TITLE: Fibrosis of the Lower Esophageal Sphincter in Achalasia

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


ORG_CITY: COLUMBIA

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

ORG_STATE: MO

PHR: PROJECT NARRATIVE Lung cancer is a leading cause of death worldwide and poses a significant physical, mental, emotional, and financial burden on patients and their families. Over the last decade there has been an increased prevalence of immunomodulating therapeutics to treat lung cancer, defining the immune systems role, or lack thereof, in disease progression and relapse; however, dose limiting adverse events and tumor resistance mechanisms still limit these reagents potency and efficacy, and thus, their ability to reduce disease burden. We propose to exploit bispecific aptamer technology to develop alternative or adjuvant therapeutics and understand what molecular design properties drive the induction of the greatest anti-cancer response.

PI_NAMEs: THOMAS, BRIAN J (contact)

PROGRAM_OFFICER_NAME: BIAN, YANSONG

PROJECT_TERMS: Address;Adenocarcinoma;Adjuvant;Adverse event;Affect;Affinity;anti-cancer;anti-tumor immune response;Antibodies;Antigen Presentation;Antitumor Response;aptamer;Aptamer Technology;Attention;Automobile Driving;Binding;Biodistribution;Biological Products;Bispecific Antibodies;burden of illness;Bypass;Cancer Biology;cancer cell;Cancer Patient;cancer subtypes;cancer therapy;Cardiovascular Diseases;Categories;Cause of Death;Cell Cycle;cell type;Cells;chemotherapy;chimeric antigen receptor T cells;Clinical;clinical translation;Clinical Trials;conventional therapy;defined contribution;design;Development;Disease;Disease Progression;Dose Limiting;Drug Kinetics;Effectiveness;efficacious treatment;Emotional;Engineering;Epidermal Growth Factor Receptor;Evaluation;Excision;Exclusion;Exercise;exhaustion;Family;Financial Hardship;Future;Generations;Goals;Hematologic Neoplasms;Heterogeneous-Nuclear Ribonucleoproteins;humanized mouse;Immune;immune activation;Immune checkpoint inhibitor;Immune system;Immune Targeting;immune-related adverse events;immunogenicity;immunological synapse;immunomodulatory therapies;immunoregulation;improved;In Vitro;in vivo;Intercellular Junctions;Kinetics;Length;Life;long term memory;lung cancer cell;Malignant neoplasm of lung;Malignant Neoplasms;Measures;Memory;Mentors;Methods;Modeling;Modification;Molecular;mouse model;Mutation;Non-Small-Cell Lung Carcinoma;non-smoker;novel;novel therapeutics;Nucleic Acids;Oligonucleotides;Oncogenes;patient derived xenograft model;Patients;Peptide/MHC Complex;Phenotype;Phosphoric Monoester Hydrolases;Play;pre-clinical;Prevalence;prevent;Process;Productivity;Property;Psyche structure;PTPRC gene;Pulmonary Inflammation;Radiation;Radon;rational design;Rationalization;Reagent;Recurrence;Relapse;Research;Resistance;resistance mechanism;response;Role;segregation;side effect;Signal Transduction;small molecule inhibitor;Smoker;Solid;Specificity;Squamous cell carcinoma;statistics;Synapses;T-Cell Activation;T-Lymphocyte;targeted treatment;Techniques;Therapeutic;Therapeutic Index;Training;transcriptomics;tumor;Tumor Antigens;tumor heterogeneity;Tumor-Infiltrating Lymphocytes;Tyrosine Kinase Inhibitor;United States

PROJECT_TITLE: Molecular engineering and systematic evaluation of bispecific aptamers to develop potent and efficacious therapies for the immunomodulation of Non-Small Cell Lung Cancer


NIH_SPENDING_CATS: Antimicrobial Resistance;Genetics;Infectious Diseases;Urologic Diseases

ORG_CITY: FARMINGTON

ORG_NAME: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT

ORG_STATE: CT

PHR: PROJECT NARRATIVE Urinary tract infections (UTIs) are estimated to affect up to 150 million people yearly, with uropathogenic Escherichia coli (UPEC) being a significant contributor to these infections. These bacteria live in nutrient-poor environments in the urinary tract and urine, which can favor antibiotic persistence and relapsing infections. This project aims to elucidate molecular mechanisms that are associated with recurrent UPEC infections, to increase the efficacy of existing antibiotics.

PI_NAMEs: LAGREE, TRAVIS  (contact)

PROGRAM_OFFICER_NAME: MARIC-BILKAN, CHRISTINE

PROJECT_TERMS: Address;adenylate;Adjuvant;Affect;Aftercare;Anabolism;Antibiotic Therapy;antibiotic tolerance;Antibiotics;Bacteria;Bacterial Infections;bacterial metabolism;Bacterial Physiology;bactericide;Biological Assay;Carbon;Cell Survival;Cells;Charge;Chemicals;Chemistry;Chemosensitization;Chimeric Proteins;Clinical;Data;Development;differential expression;DNA;DNA Binding;DNA biosynthesis;DNA Damage;DNA lesion;DNA Repair;DNA Repair Gene;DNA Topoisomerases;drug resistant pathogen;Environment;Escherichia coli;Escherichia coli Infections;Event;Excision;experimental study;Flow Cytometry;Fluorescence;Fluorescence Microscopy;Fluorescence-Activated Cell Sorting;Fluorescent Antibody Technique;Fluorescent Dyes;Fluoroquinolones;Frequencies;Future;Gene Expression;Genes;Genetic;genetic approach;Genetic Transcription;Glucose;Growth;improved;Infection;insight;Knowledge;Mass Spectrum Analysis;Measures;Metabolic;Metabolism;metabolomics;microbial disease;Microscopy;Modeling;Molecular;mutant;Mutation;non-genetic;Nucleic Acids;Nucleotides;Nutrient;Nutrient availability;nutrient deprivation;persistent bacteria;Persons;Pharmaceutical Preparations;Phenotype;Physiology;Population;Predisposition;programs;Recovery;Recurrence;Relapse;repaired;Reporter;Research;Resistance;Resistance development;response;RNA;Sorting;Source;Stress;success;System;Testing;Topoisomerase;transcriptome sequencing;Translating;Treatment Failure;treatment response;Urinary tract;Urinary tract infection;Urine;Uropathogenic E. coli

PROJECT_TITLE: Investigating metabolism and DNA damage repair in uropathogenic Escherichia coli fluoroquinolone persisters


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Genetic Testing;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE African Americans are less likely to receive genetic testing to determine if they have a genetic mutation associated with increased risk for certain cancers. When testing is done, it is important to share information with relatives to help them determine whether or not they too would benefit from testing; however, it can be difficult to share this information within families. This project will develop and test an intervention specifically tailored for African American families to support their communication about cancer genetic testing results, communication about behaviors that can reduce their cancer risk, and future decisions about whether or not to complete cancer genetic testing.

PI_NAMEs: ELLIS, KATRINA RENEE (contact)

PROGRAM_OFFICER_NAME: WALI, ANIL

PROJECT_TERMS: acceptability and feasibility;Active Learning;Adult;African American;African American population;Anxiety;Area;Attitude;Award;Behavior;behavior change;Behavioral;Behavioral trial;Belief;Breast;Cancer Burden;cancer genetics;cancer health disparity;cancer risk;cancer type;career;career development;cascade genetic testing;Clinic;Colorectal;commune;Communication;Communication difficulty;communication theory;contextual factors;coping;Data;Death Rate;Development;Diet;DNA Sequence Alteration;economic disparity;Educational Status;Educational workshop;eHealth;Ethnic Population;Evaluation;experience;Extended Family;Face;Faith;Family;Family Caregiver;Family health status;Focus Groups;Future;Generations;Genetic;Genetic Counseling;genetic information;genetic testing;Germ-Line Mutation;Goals;Grant;Health;Health behavior;health disparity;Health education;Hereditary Breast and Ovarian Cancer Syndrome;Hereditary Malignant Neoplasm;Hereditary Neoplastic Syndromes;hereditary risk;high risk;improved;improved outcome;Individual;Inherited;Intervention;intervention program;Intervention Studies;K-Series Research Career Programs;Knowledge;Learning;Life;lifestyle intervention;Longitudinal Studies;Malignant Neoplasms;Manuscripts;Medical Genetics;Mental Health;Mentored Research Scientist Development Award;Mentors;Modification;motivational enhancement therapy;Outcome;Outcome Study;Pattern;Persons;Physical activity;pilot test;Politics;Population;Positioning Attribute;post-doctoral training;Process;psychosocial;Public Health;racial population;randomized, clinical trials;Recommendation;Recording of previous events;Reporting;Research;Research Personnel;Resources;response;Risk;Self Determination;skills;Smoking;Social status;Social Work;Spirituality;symposium;tailored messaging;Test Result;Testing;testing uptake;theories;therapy design;therapy development;transmission process;United States;uptake;Writing

PROJECT_TITLE: Family Centered Approaches to Promoting Cascade Screening for Hereditary Cancer Syndromes among African Americans


NIH_SPENDING_CATS: Cancer;Immunotherapy

ORG_CITY: BUFFALO

ORG_NAME: ROSWELL PARK CANCER INSTITUTE CORP

PHR: Project Narrative The data generated in preclinical cancer research are often unreproducible and not translatable to the clinic. The goal of this proposal is to better understand the full impact of housing conditions on the animal models we rely on for studying cancer and the anti-tumor immune response by studying the influence of laboratory rodent housing temperature on murine CD8+ T cell anti-tumor immunity and response to immunotherapy. The knowledge gained from these studies will have direct implications on the role of laboratory housing conditions as a variable in murine models of cancer and immunotherapy.

PI_NAMEs: JAMES, CAITLIN M (contact)

PROGRAM_OFFICER_NAME: PURI, ANU

PROJECT_TERMS: Address;adrenergic stress;Affect;Animal Housing;Animal Model;Animals;anti-cancer research;anti-PD-1;anti-tumor immune response;Basal metabolic rate;beta-adrenergic receptor;Biomedical Research;Cancer Model;cancer therapy;career;Caring;CD28 gene;CD8-Positive T-Lymphocytes;CD8B1 gene;Chronic;Clinic;Clinical;cold stress;Data;design;Development;Down-Regulation;effector T cell;environmental stressor;experience;falls;Flow Cytometry;Functional impairment;Genetically Engineered Mouse;Goals;guide for the care and use of laboratory animals;Guidelines;Harvest;House mice;Housing;Human;human disease;human model;Immune;Immune checkpoint inhibitor;Immunologics;Immunotherapy;Impairment;improved;In Vitro;in vivo;insight;Institution;Knockout Mice;Knowledge;Laboratories;Laboratory Animal Science;Laboratory Animals;Malignant Neoplasms;Measures;Mediating;Medical;Melanoma;Modeling;Molecular;Molecular Target;mouse model;mRNA Expression;Mus;Nerve;Norepinephrine;novel therapeutics;Outcome;Pathway interactions;Patients;Phenotype;Physiological;Play;pre-clinical;Pre-Clinical Model;preclinical study;Process;protein expression;Publishing;receptor;Receptor Signaling;Reproducibility;Research;Research Proposals;response;Rodent;Role;Signal Induction;Signal Transduction;Standardization;success;Surface;Sympathetic Nervous System;T-Cell Activation;T-Lymphocyte;Temperature;Testing;therapy development;Thermogenesis;Training;translational potential;treatment response;tumor;tumor growth;Tumor Immunity;tumor immunology;Tumor-Infiltrating Lymphocytes;Work

PROJECT_TITLE: Examining the impact of laboratory housing temperature on murine CD28 and the response to anti-PD-1


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Cancer;Brain Disorders;Cancer;Dental, Oral, and Craniofacial Disease;Machine Learning and Artificial Intelligence;Neurosciences;Rare Diseases

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: 8. Project Narrative We aim to develop next-generation medical imaging technologies that would allow the creation of hematoxylin and eosin (H&E) biopsy-like images but without cutting the tissue and in real time. This imaging technology may provide both new basic understanding of cancer development, and clinical tools to aid in early diagnosis and tumor margin detection for better treatment management of cancer patients. As a first application, we aim to demonstrate virtual H&E biopsy on brain tumors, ultimately giving surgeons the ability to precisely determine brain tumor margins during surgery but before actually cutting into the brain.

PI_NAMEs: WINETRAUB, YONATAN  (contact)

PROGRAM_OFFICER_NAME: MILLER, BECKY

PROJECT_TERMS: 3-Dimensional;Acceleration;Aerospace Engineering;Affect;Algorithms;Animals;Area;Award;Bar Codes;Biological Markers;biomedical imaging;Biophysics;Biopsy;Brain;Brain Glioblastoma;Brain Neoplasms;brain tissue;cancer cell;Cancer Patient;Cancerous;Cells;Clinical;Collaborations;computational neuroscience;Contrast Media;COVID-19;Data Set;Dedications;Department chair;Detection;Development;Devices;Diagnosis;Disease;Early Diagnosis;Electrical Engineering;Entrepreneurship;Excision;experience;Feasibility Studies;Funding;generative adversarial network;Glioblastoma;Glioma;Goals;Grant;Harvest;Hematoxylin and Eosin Staining Method;Heterogeneity;High School Student;Histology;Human;human data;human imaging;human tissue;Image;image translation;Imaging Device;imaging modality;Imaging technology;improved;in vivo;in vivo imaging;in vivo optical imaging;Industry;Injections;Institution;instructor;instrumentation;Interdisciplinary Study;International;Laboratories;Legal patent;Length;Letters;Location;Machine Learning;Malignant Childhood Neoplasm;Malignant neoplasm of brain;Malignant Neoplasms;Medical Imaging;Mentors;Methods;millimeter;Modeling;Monitor;Moon;mortality;mouse model;Mus;neural;neural network;next generation;Noise;nonhuman tissue;novel;Operative Surgical Procedures;Optical Coherence Tomography;optical imaging;Optics;Organ;Pediatric Neoplasm;Persons;Physics;Positioning Attribute;Postdoctoral Fellow;Procedures;Process;professor;programs;Protocols documentation;Public Speaking;Publications;Reporting;Research;Residual Cancers;Retina;Sampling;Scanning;Science, Technology, Engineering and Mathematics Education;Secure;Skin;Skin Cancer;Skin Tissue;Slide;Solid;Solid Neoplasm;Stains;structural biology;Structure;Students;success;Supervision;Surgeon;System;Techniques;Technology;tenure track;Time;Tissue Sample;Tissue Stains;Tissues;tool;Training;training data;transfer learning;Translations;Treatment Efficacy;treatment response;tumor;tumor diagnosis;tumor progression;Tumor Tissue;Uncertainty;Universities;virtual;virtual biopsy;Visualization;Work

PROJECT_TITLE: OCT as a Platform for Non-Invasive Virtual H&E Biopsy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-H(70)R]


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Atherosclerosis;Brain Disorders;Cardiovascular;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Neurosciences;Patient Safety;Prevention;Stroke

ORG_CITY: BIRMINGHAM

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: In the United States, more than 100,000 carotid endarterectomy or stent procedures are performed annually on patients with narrowing of a carotid artery due to atherosclerosis who have not yet experienced symptoms of a stroke. Recent advances in medical management of atherosclerotic disease have raised questions regarding the net benefit of these procedures to prevent stroke. We are requesting support to complete two parallel multicenter randomized clinical trials, one comparing intensive medical management (IMM) vs. endarterectomy plus IMM (n=1240), the other comparing IMM vs. stenting plus IMM (n=1240).

PI_NAMEs: EDWARDS, LLOYD J (contact)

PROGRAM_OFFICER_NAME: JANIS, SCOTT

PROJECT_TERMS: Abbreviations;Acceleration;Address;adjudication;Adult;Affect;Age;Ancillary Study;Applications Grants;artery stenosis;Atherosclerosis;atherothrombosis;Blinded;Blood Pressure;Canada;cardiovascular risk factor;Carotid Arteries;Carotid Atherosclerotic Disease;Carotid Endarterectomy;Carotid Stenosis;Carotid stent;Cessation of life;cigarette smoking;Clinic;clinical application;Clinical Trials;Clinical Trials Data Monitoring Committees;cognitive change;cognitive function;cognitive testing;cohort;Companions;compare effectiveness;Computer Assisted;COVID-19;COVID-19 pandemic;Credentialing;Data;Data Coordinating Center;data management;design;Devices;Diabetes Mellitus;Doppler Ultrasound;efficacy evaluation;Endarterectomy;Enrollment;Ensure;Event;experience;follow up assessment;follow-up;Funding;Goals;Hyperlipidemia;Hypertension;hypoperfusion;improved;Informed Consent;inhibitor;Ipsilateral;Knowledge;LDL Cholesterol Lipoproteins;Life Style;Lipoproteins;Maryland;Medical;Medical Records;meetings;Modernization;Monitor;Multicenter Trials;operation;Operative Surgical Procedures;Outcome;Outcome Study;Patient Recruitments;Patients;Periodicals;prevent;primary endpoint;primary outcome;Primary Prevention;Procedures;Proprotein Convertases;Radial;Randomized;randomized trial;randomized, clinical trials;Recommendation;recruit;Reporting;Research Design;Research Personnel;restenosis;revascularization;Risk;Risk Factors;Risk Reduction;safe patient;secondary endpoint;secondary outcome;Serine Protease;Severities;sex;Site;Spain;Standardization;statistical center;Statistical Data Interpretation;Stenosis;Stents;Stroke;stroke event;Stroke prevention;stroke risk;Subtilisins;success;Surgeon;Symptoms;telephone delivery;Telephone Interviews;therapeutic target;treatment arm;treatment group;trial comparing;United States;Universities;vascular risk factor;Withdrawal

PROJECT_TITLE: CREST-2 Statistical and Data Coordinating Center - SDCC


NIH_SPENDING_CATS: Cancer;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Genetics;Orphan Drug;Pancreatic Cancer;Radiation Oncology;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: Columbus

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative Cellular phenotypic heterogeneity within tumors, such as subpopulations of cells with increased capacity for self-renewal referred to as cancer stem cells, exists within many cancers is believed to drive resistance to therapies such and radiation and chemotherapy. Our preliminary results in pancreatic cancer revealed a supportive niche of Wnt-secreting cancer cells that drives a Lgr5+ stem-cell-like state in another cancer cell subpopulation, thereby promoting and maintaining stemness within pancreatic tumors. This proposal will test the hypothesis that Wnt-driven cellular phenotypic heterogeneity and stemness promote radioresistance in pancreatic tumors.

PI_NAMEs: PITTER, KENNETH L (contact)

PROJECT_TERMS: Ablation;Acyltransferase;Address;Adult;Animal Experimentation;Animals;Award;Biochemical;Biological;Biological Assay;Cancer Biology;cancer cell;cancer heterogeneity;cancer stem cell;cancer type;Career Mobility;Cell Differentiation process;cell type;Cells;Characteristics;chemotherapy;Chemotherapy and/or radiation;Clinic;Clinical;Clinical Management;Colorectal Adenocarcinoma;conventional therapy;Core Facility;Data;disorder control;Eligibility Determination;Enzymes;Epigenetic Process;Evolution;experience;Faculty;Gene Expression Profiling;Genetic;Genetic Heterogeneity;Genetically Engineered Mouse;Goals;graduate student;Heterogeneity;Human;immune activation;Immunocompetent;Immunotherapy;improved;Individual;inhibitor;insight;Institution;interest;Laboratories;Laboratory Research;Letters;LGR5 gene;Ligands;Localized Disease;Lung Adenocarcinoma;Malignant neoplasm of pancreas;Malignant Neoplasms;member;Memorial Sloan-Kettering Cancer Center;Mentors;Methods;Minority;Molecular;Mus;novel therapeutic intervention;Operative Surgical Procedures;palmitoylation;Pancreas;Pancreatic Adenocarcinoma;pancreatic cancer cells;pancreatic cancer model;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;pancreatic ductal adenocarcinoma model;Pancreatic Injury;pancreatic neoplasm;Pathway interactions;Patients;pharmacologic;Phenotype;Population;Porcupines;Positioning Attribute;Postdoctoral Fellow;Productivity;professor;Prognosis;programs;Property;Radiation;radiation resistance;Radiation therapy;Radiation-Sensitizing Agents;Radiosensitization;Research;Resistance;Resources;response;Role;Secure;self-renewal;Shapes;small molecule;stem;stemness;Stimulation of Cell Proliferation;targeted treatment;tenure track;Testing;Therapeutic;therapeutic evaluation;therapeutic target;therapy resistant;Training;transcriptomics;Translating;Translations;treatment response;treatment strategy;tumor;tumor growth;tumor heterogeneity;tumor microenvironment;WNT Signaling Pathway;Work

PROJECT_TITLE: Cellular phenotypic heterogeneity and resistance to radiotherapy in pancreatic adenocarcinoma


NIH_SPENDING_CATS: Brain Disorders;Data Science;Networking and Information Technology R&D (NITRD);Neurosciences;Physical Injury - Accidents and Adverse Effects;Spinal Cord Injury;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: SAN FRANCISCO

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE: Sharing of multicenter, multispecies central nervous system (CNS) injury data provides a unique and clinically-relevant opportunity to discover treatments, if we can develop data management workflows make these data findable, accessible, interoperable and reusable (FAIR). Our team has assembled some of largest repositories of such data spanning across traumatic brain injury and spinal cord injury under prior NIH support. The proposed project will develop, test, and optimize management workflows to help render these raw data into novel insights that lead to treatments for the major health crisis of CNS injury.

PI_NAMEs: FERGUSON, ADAM R (contact);FOUAD, KARIM ;GRETHE, JEFFREY S.;LEMMON, VANCE P

PROGRAM_OFFICER_NAME: VOLFOVSKY, NATALIA

PROJECT_TERMS: Acceleration;Adoption;advanced analytics;Affect;Anatomy;Animal Model;Behavioral;Big Data;Big Data Methods;Body System;Brain;Central Nervous System;central nervous system injury;Certification;clinical implementation;clinically relevant;Collaborations;Common Data Element;Communities;community engagement;Complex;complex data;Controlled Vocabulary;cost;dashboard;Data;Data Analyses;Data Commons;data complexity;data dashboard;data format;data interoperability;data management;data mining;Data Pooling;data quality;data repository;data resource;data reuse;Data Set;data sharing;data standards;data visualization;data wrangling;Dedications;digital object identifier;Disease;Disparate;diverse data;economic cost;economic impact;Ecosystem;Educational workshop;experience;experimental study;FAIR principles;Feedback;Functional disorder;Future;Generations;Goals;Health;Healthcare;Heterogeneity;Human;human data;Impairment;improved;Individual;information framework;Infrastructure;Injury;insight;International;Internet;interoperability;Knowledge;Laboratories;large scale data;Licensing;Life Cycle Stages;Medical;Metadata;Monitor;Multiple Trauma;Mus;National Institute of Neurological Disorders and Stroke;Nervous System Trauma;neuroinformatics;Neurosciences;new technology;novel;novel marker;Ontology;open data;open source;operation;Oranges;Outcome Assessment;Outcome Measure;Persons;Physiology;Police;Policies;Positioning Attribute;pre-clinical;precision medicine;Predictive Value;preservation;Prevalence;Process;Productivity;productivity loss;prospective;public repository;Publication Bias;Publications;quality assurance;Quality Control;Rattus;Recovery;Recovery of Function;repaired;Reporting;repository;Reproducibility;Reproducibility of Results;Research;Research Personnel;Severities;Site;skills;Spinal Cord;spinal cord and brain injury;Spinal cord injury;Standardization;Structure;success;symposium;Syndrome;System;Terminology;Testing;therapeutic development;therapeutic evaluation;Tissue Expansion;tool;translational medicine;translational therapeutics;Translations;Trauma;Traumatic Brain Injury;Traumatic CNS injury;Treatment Efficacy;trustworthiness;U-Series Cooperative Agreements;United States National Institutes of Health;virtual laboratory;web portal;webinar;Work

PROJECT_TITLE: Pan-Neurotrauma Data Commons

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-T(55)R]


NIH_SPENDING_CATS: Neurosciences

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE. A healthy nervous system requires the polarization of neurons into structurally and functionally distinct compartments. Both the axon initial segment and the microtubule cytoskeleton play key roles in neuronal polarity, and disruption of either causes profound defects in neuronal structure and function. This project seeks to understand how the axon initial segment and microtubules interact to establish and maintain neuronal polarity.

PI_NAMEs: MELTON, ALLISON JACQUELINE (contact)

PROGRAM_OFFICER_NAME: KIM, JENNY LILY

PROJECT_TERMS: Action Potentials;ANK3 gene;Axon;axon regeneration;Axonal Transport;Behavior;Behavioral;Brain;Cells;Complex;Cytoskeletal Filaments;Cytoskeleton;Data;Defect;Dendrites;density;Dependovirus;Development;Diffusion;Environment;Exhibits;experience;experimental study;Fascicle;Foundations;Gatekeeping;immunoreactivity;Impairment;in utero;In Vitro;in vivo;Injections;Injury;insight;Ion Channel;knock-down;Knock-out;Knockout Mice;Label;loss of function;Memory;Methods;Microscopy;Microtubules;migration;Molecular;molecular polarity;Morphology;Movement;Mus;Muscle;Muscle fasciculation;Nerve Crush;Nervous System;Neurodegenerative Disorders;Neurodevelopmental Disorder;Neurons;Play;Population;prevent;Process;protein distribution;Proteins;Publishing;recruit;Reporting;Resolution;Role;sciatic nerve;small hairpin RNA;Specific qualifier value;Structure;superresolution microscopy;Testing;Thinness;Toxic effect;trafficking;Training;Transmission Electron Microscopy;transmission process;TRIM Motif;Work

PROJECT_TITLE: Role of TRIM46 in neuronal polarity in vivo


NIH_SPENDING_CATS: Lung;Pediatric;Pulmonary Hypertension

PHR: PROJECT NARRATIVE The needs for skilled academic physician-scientists in Pediatric Pulmonary Vascular Disease and multi- institutional, collaborative and rigorous investigation of new treatment modalities with focus on pathobiology and long-term outcomes are clear. The goal of the training program is to increase the number of highly-trained, successfully-funded and sustainable pediatric pulmonary vascular disease physician-scientists, who will perform high level laboratory, clinical-translational research, and/or health services research that will improve our understanding of the pathobiology of pediatric pulmonary vascular disease, and thereby improve short and long- term outcomes for this complex, vulnerable population. This training program uniquely leverages existing collaborative, multicenter and interdisciplinary academic programs as critical infrastructure that will provide outstanding training opportunities for career development in the field.

PI_NAMEs: ABMAN, STEVEN HERBERT;AUSTIN, ERIC DOUGLAS;FINEMAN, JEFFREY R (contact)

PROGRAM_OFFICER_NAME: KALANTARI, ROYA

PROJECT_TERMS: Childhood;Interdisciplinary Study;pulmonary vascular disorder;Research Training

PROJECT_TITLE: Multidisciplinary Research Training in Pediatric Pulmonary Vascular Disease

STUDY_SECTION: NITM

STUDY_SECTION_NAME: NHLBI Institutional Training Mechanism Study Section[NITM(JA)]


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: BALTIMORE

ORG_DEPT: NEUROLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative (Relevance) Millions of Americans are misdiagnosed each year, sometimes with devastating consequences such as permanent disability or death. This proposal will expand the activities of an existing academic Center for Diagnostic Excellence whose focus is to eliminate patient harms from diagnostic error. Projects supported by this proposal will focus on achieving diagnostic excellence in the emergency department through research and quality improvement activities, including (a) clinical programs to eliminate stroke misdiagnosis, (b) new methods of diagnostic error incident reporting by physicians, and (c) a software tool to help measure the projected return on investment for new diagnostic strategies that will help spread these innovations.

PI_NAMEs: MCDONALD, KATHRYN MACK;NEWMAN-TOKER, DAVID  (contact)

PROGRAM_OFFICER_NAME: COSBY, KAREN

PROJECT_TITLE: Armstrong Institute Center for Diagnostic Excellence-Pursuing Scalable System-Level Diagnostic Quality, Value and Equity by Applying Safety Science to Emergency Department Diagnosis


ORG_CITY: KANSAS CITY

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: Project Narrative  This project will develop truly-”2D” proton-photon joint optimization methods for clinically-deliverable truly- hybrid RT with unprecedented superior plan quality to proton-only and photon-only RT, and first-of-its-kind TPS to bridge truly-hybrid RT from research to clinic. This hybrid TPS can facilitate prospective clinical trials of a broad spectrum of treatment sites for many patients. If succeed, truly-hybrid RT via this first-of-its-kind TPS will likely warrant improved clinical outcomes with reduced OAR toxicities, and potentially become a new paradigm for cancer RT in general, with compelling benefits in both treatment cost and clinical outcomes.

PI_NAMEs: GAO, HAO  (contact)

PROGRAM_OFFICER_NAME: OBCEMEA, CEFERINO H

PROJECT_TERMS: Automobile Driving;Bathing;Cancer Center;Cancer Patient;cancer radiation therapy;Clinic;Clinical;clinical application;Clinical Trials;deep learning;Devices;Dose;Equipment;Hospitals;Hour;Hybrids;Immobilization;improved;Individual;Infrastructure;innovation;Joints;Methods;Modeling;novel;Organ;Outcome;Patients;Photons;Physicians;Procedures;prospective;Protons;Radiation therapy;Radiotherapy Research;Recording of previous events;Risk;simulation;Speed;Structure;success;synergism;System;Technology;Testing;Toxic effect;Travel;Treatment Cost;treatment planning;treatment site;Uncertainty;Work

PROJECT_TITLE: Novel Optimization Methods and Treatment Planning System for Clinically-Deliverable Truly-Hybrid Proton-Photon Radiotherapy

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Dental, Oral, and Craniofacial Disease;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative More than five million people in the United States living with Alzheimer’s disease, and this number grows substantially due to the population aging, resulting in burdens on the economy, families and caregivers of patients. While volumetric MRI biomarkers are useful to assess the risk of Alzheimer’s disease, their diagnostic value is still limited since the association between biomarkers and neuropathological changes remains unclear. With the help of advanced high-gradient MRI system, this project will establish an in vivo diffusion MRI microscopy technology targeting tissue microstructure in the brain gray matter, which will expand our understanding of underlying mechanisms of disease progression, and may provide prognostic and confirmatory biomarkers and aid in the assessment of treatment efficacy for Alzheimer’s disease and related dementias.

PI_NAMEs: LEE, HONG HSI  (contact)

PROJECT_TERMS: 3-Dimensional;aging population;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease related dementia;Alzheimer's disease risk;Amyloid;Amyloid beta-Protein;Applications Grants;Award;Axon;Biological Markers;biomedical imaging;biophysical model;Blood;Brain;brain tissue;career;career development;Caregivers;Cell Size;Cells;Cerebrospinal Fluid Proteins;Clinic;Clinical;clinical translation;cluster computing;Computer software;connectome;Data;Dementia;density;Development;diagnostic value;Diffusion;Diffusion Magnetic Resonance Imaging;Disease;Disease Progression;Doctor of Philosophy;Early Diagnosis;Early identification;Early Onset Alzheimer Disease;Electron Microscopy;Ensure;Estimation Techniques;Evaluation;experience;experimental study;Faculty;Family;Future;General Hospitals;Geometry;Goals;graduate student;gray matter;high dimensionality;High Performance Computing;high risk;Histologic;Histology;Histopathology;Human;imaging biomarker;imaging facilities;Imaging Techniques;Impaired cognition;in vivo;innovative technologies;Institution;instructor;Interdisciplinary Study;Intervention;Joints;Knowledge;Laboratories;Leadership;Learning;light microscopy;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Massachusetts;Measurement;Measures;medical schools;Medicine;meetings;Mentorship;microCT;Microscopic;Microscopy;mild cognitive impairment;Monitor;Monte Carlo Method;Mus;Nerve Degeneration;Neurites;Neurodegenerative Disorders;neuronal cell body;Neurons;neuropathology;next generation;non-invasive imaging;novel;novel therapeutics;Onset of illness;Paper;Pathologic;Patients;Peer Review;Persons;Physics;Positioning Attribute;Positron-Emission Tomography;Postdoctoral Fellow;prognostic;protein biomarkers;Radiology Specialty;Research;research study;Resolution;Resource Sharing;Risk;Risk Assessment;Running;Scientist;senior faculty;simulation;skills;Structure;success;Symptoms;System;tau Proteins;tau-1;Techniques;Technology;Testing;theories;Three-dimensional analysis;Time;Tissues;tool;Training;Translating;Treatment Efficacy;treatment response;United States;Validation;Varicosity;white matter;white matter change;Work

PROJECT_TITLE: Revealing tissue microstructure in the brain gray matter in Alzheimer's disease using in vivo high-gradient diffusion MRI