NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Liver Cancer;Liver Disease;Orphan Drug;Rare Diseases

ORG_DEPT: BIOMEDICAL ENGINEERING

PHR: Histotripsy is a new method of non-invasive surgery using focused ultrasound. This proposal seeks to improve the procedure by developing optimized methods for correcting wavefront aberration caused by varying speed of sound in different abdominal tissue layers overlying the target. By correcting aberration, the range of targets in the body and population of patients which can be treated with histotripsy will be greatly expanded.

PI_NAMEs: HALL, TIMOTHY L (contact)

PROGRAM_OFFICER_NAME: OBCEMEA, CEFERINO H

PROJECT_TERMS: Abdomen;Ablation;Abscopal effect;Accounting;Acoustics;bile duct;Blood Vessels;Cadaver;Calibration;Clinical;Clinical Trials;Data;design;Disease;Elements;Europe;Event;Family suidae;Feedback;Focused Ultrasound;follow-up;Fracture;Generations;Goals;heart motion;Heterogeneity;Human;Image;imager;Imaging Techniques;improved;In Situ;in vivo;Liver;liver ablation;liver tumor ablation;Location;Malignant neoplasm of liver;Measurement;Measures;Mechanics;Methods;millimeter;millisecond;Motion;MRI Scans;multi-site trial;Nature;next generation;Operative Surgical Procedures;Output;patient population;patient tolerability;Patients;Performance;Physiologic pulse;Population;Population Heterogeneity;porcine model;preservation;pressure;Procedures;Radial;resilience;respiratory;Risk;Running;Safety;simulation;sound;Source;Speed;Structure;Techniques;Technology;Testing;Therapeutic;Therapeutic Effect;therapeutic target;Tissues;Transducers;transmission process;tumor;Ultrasonography;ultrasound;Uncertainty;Validation;Variant;Visualization;X-Ray Computed Tomography

PROJECT_TITLE: Aberration Correction for Histotripsy Ablation of Liver

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]


ADMINISTERING_IC: HL

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: BIRMINGHAM

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Project Narrative This proposal has direct public health relevance since it proposes novel strategies to prevent and treat heart failure which is a major public health problem with a worldwide prevalence of 38 million. By identifying the underlying mechanisms of heart failure, our studies should allow rational development of effective therapeutic approaches to prevent myocardial fibrotic remodeling and heart failure. Thus, the proposed research is relevant to the part of NIH's mission that pertains to developing fundamental knowledge that will help to reduce the burdens of heart diseases worldwide.

PI_NAMEs: LAL, HIND  (contact)

PROGRAM_OFFICER_NAME: ADHIKARI, BISHOW B

PROJECT_TERMS: Adult;beta catenin;Biology;Cardiac;Cardiac Myocytes;cardioprotection;Cells;coronary fibrosis;Development;Dose;efficacy testing;Embryo;Family;Fibroblasts;Fibrosis;Foundations;Funding;gain of function;Gene Deletion;Gene Targeting;Genetic Models;Glycogen Synthase Kinase 3;glycogen synthase kinase 3 beta;Goals;Grant;Heart;Heart Diseases;Heart failure;Heterozygote;in vivo;inhibitor;Investigation;Knock-in;Knock-in Mouse;Knockout Mice;Knowledge;Mediating;Medicine;MEKs;Mission;Modeling;Molecular;mouse model;Mus;Myocardial;Myocardial dysfunction;new therapeutic target;novel;novel strategies;Pathway interactions;pharmacologic;Phenotype;Phosphotransferases;pill;predict clinical outcome;Prevalence;prevent;Profibrotic signal;Progress Reports;Protein Isoforms;Public Health;public health relevance;Publications;Regulation;Reporting;Research;response;Role;Second Messenger Systems;Signal Transduction;small molecule inhibitor;Study models;therapeutic target;therapeutically effective;Tissues;tool;translational potential;translational study;United States National Institutes of Health;virtual

PROJECT_TITLE: Signaling Mechanisms Governing Myocardial Fibrosis in Diseased Heart

STUDY_SECTION: MPPA

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology A Study Section [MPPA]


ADMINISTERING_IC: DC

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Biomedical Imaging;Clinical Research;Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Pediatric;Precision Medicine;Prevention

ORG_CITY: LARAMIE

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF WYOMING

ORG_STATE: WY

PHR: PROJECT NARRATIVE For children with cleft palate, failed surgeries and corresponding speech issues result in pervasive communication disorders that limit participation in society and are accompanied by a financial burden for families. This study will quantify anatomy and speech production before and after palate repair surgery for infants with cleft palate to identify mechanisms for surgical selection and early speech monitoring. Results of this research will provide essential information about patient-specific intervention and help us move toward understanding speech development and advancing treatment outcomes in individuals with repaired cleft palate.

PI_NAMEs: KOTLAREK, KATELYN JOY (contact)

PROGRAM_OFFICER_NAME: KOPF, LISA MARIE

PROJECT_TERMS: Address;Age;Age Months;Anatomy;Articulation;Basic Science;Biological Markers;care burden;Caring;Child;Childhood;Cleft Palate;Clinical;Communication impairment;Congenital Abnormality;craniofacial;Data;Development;Dimensions;Early identification;Early Intervention;Early treatment;Enrollment;experience;Failure;Family;family burden;Financial Hardship;Future;Goals;Health Care Costs;Hearing;Home;improved;improved outcome;Incidence;Individual;individualized medicine;Infant;innovation;Intervention;Knowledge;Language;Language Development;Length;Literature;Magnetic Resonance Imaging;Monitor;Muscle;Nasal cavity;Nose;novel;Operative Surgical Procedures;Oral;Oral cavity;orofacial cleft;Outcome;Palate;palate repair;Participant;Patient Care;Patients;peer;Physiological;Policies;Population;precision medicine;pressure;prevent;Procedures;Production;Protocols documentation;Provider;psychosocial;Reconstructive Surgical Procedures;repaired;Reporting;Research;response;Risk Factors;Scanning;skills;Societies;Speech;Speech Acoustics;Speech Development;Speech Intelligibility;Speech Therapy;success;Surgical Management;Techniques;Technology;Time;Tissues;Toddler;Training;Treatment outcome;Uncertainty;United States;Velopharyngeal Insufficiency;Width

PROJECT_TITLE: Using MRI to Facilitate Precision Medicine for Infants with Cleft Palate

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Services;Hematology;Mental Health;Palliative Care;Regenerative Medicine;Social Determinants of Health;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Family and friend caregivers of patients undergoing hematopoietic stem cell transplantation (HCT) confront substantial psychological and caregiving burden as they provide support for patients during a prolonged transplant hospitalization, manage complex medications and weekly outpatient medical appointment schedules during an intense post-transplant recovery period, and cope with the uncertainty of the patient’s long-term prognosis. Despite the immense physical and psychological burden placed on these caregivers, interventions to address the needs of this vulnerable population are lacking. This proposal seeks to assess the efficacy and potential for scalability and implementation of a psychosocial intervention (BMT-CARE) to provide caregivers of patients undergoing HCT with the skills to effectively cope with the patients’ illness with the goals of improving caregivers’ quality of life, mood, burden, and self-efficacy, patient-reported psychosocial outcomes, and patients’ and caregivers’ health care utilization.

PI_NAMEs: EL-JAWAHRI, AREEJ  (contact);JACOBS, JAMIE MICHELE

PROGRAM_OFFICER_NAME: ADAMS, LYNN S

PROJECT_TERMS: Address;Adoption;Alabama;anxiety symptoms;Appointments and Schedules;Behavioral;Buffers;Cancer Center;care giving burden;Caregiver Burden;caregiver interventions;caregiver quality of life;Caregiver support;Caregivers;Caring;Clinic Visits;clinical practice;clinically significant;Cognitive;comparative efficacy;Complex;coping;Coping Skills;Data;depressive symptoms;Deterioration;dissemination trial;Distress;effectiveness-implementation randomized trial;efficacy evaluation;efficacy testing;Eligibility Determination;Emotional;Enrollment;Ensure;Environment;Evaluation;experience;Face;Family;Foundations;Friends;Future;future implementation;General Hospitals;Goals;health care service utilization;Hematologic Neoplasms;Hematopoietic Stem Cell Transplantation;High Dose Chemotherapy;Hospitalization;Hour;Hybrids;implementation determinants;implementation intervention;implementation trial;improved;improved outcome;Individual;Infrastructure;innovation;Inpatients;Intervention;Length of Stay;loved ones;Massachusetts;Measures;Medical;medical appointment;Methods;Moods;multimodality;Oncology;Outcome;Outpatients;Palliative Care;Patient Compliance;Patient Outcomes Assessments;patient prognosis;Patient-Focused Outcomes;Patients;persistent symptom;Persons;Pharmaceutical Preparations;physical symptom;pilot trial;Population;Population Intervention;post-transplant;primary caregiver;primary endpoint;Process;Prognosis;psychologic;psychological distress;psychosocial;psychosocial outcome;Qualitative Evaluations;Quality of life;Randomized;randomized trial;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recovery;Regimen;Reporting;Research;Sampling;scale up;Self Efficacy;Site;skills;Social support;stress management;success;Supportive care;Symptom Burden;Telephone;Testing;Toxic effect;Training;Translations;Transplant Recipients;Transplantation;treatment as usual;Uncertainty;Universities;videoconference;Visit;Vulnerable Populations

PROJECT_TITLE: BMT-CARE: Multimodal Psychosocial Intervention for Caregivers of Patients Undergoing Hematopoietic Stem Cell Transplantation

STUDY_SECTION: ICSC

STUDY_SECTION_NAME: Interdisciplinary Clinical Care in Specialty Care Settings Study Section[ICSC]


NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Immunotherapy;Lung;Palliative Care;Radiation Oncology

ORG_CITY: BUFFALO

ORG_NAME: ROSWELL PARK CANCER INSTITUTE CORP

ORG_STATE: NY

PHR: Project Narrative The goal of this project is to improve treatment outcomes for patients with external locally advanced cancer that causes airway obstructions. These patients are not candidates for surgery and have no effective treatments. We propose that patients will benefit from a promising combination of interstitial photodynamic therapy with low dose radiotherapy that preliminary data show to safely ablate tumor and improve survival.

PI_NAMEs: BUSCH, THERESA M;IVANICK, NATHANIEL T;SHAFIRSTEIN, GAL  (contact)

PROGRAM_OFFICER_NAME: BUCHSBAUM, JEFFREY

PROJECT_TERMS: Address;Adverse event;Aftercare;airway obstruction;Atelectasis;Balloon Dilatation;Blood;Blood specimen;Breathing;Cancer Etiology;Caring;CD8-Positive T-Lymphocytes;chemotherapy;Clinical;Data;design;Disease;Dose;Dose Rate;effective therapy;Excision;Face;Fistula;Future;Goals;Hemorrhage;Image;image guided;Immune response;Immunologic Markers;Immunotherapy;improved;In complete remission;Institutional Review Boards;interstitial;Ionizing radiation;Lasers;Light;light dosimetry;light transmission;Locally Advanced Malignant Neoplasm;Malignant - descriptor;Malignant neoplasm of lung;Malignant Neoplasms;Measures;Mediating;Minority;Modeling;Morbidity - disease rate;mouse model;Mus;Myeloid-derived suppressor cells;Neoplasm Metastasis;Normal tissue morphology;novel;Obstruction;Operative Surgical Procedures;Outcome;Oxygen;palliative;Palliative Care;Participant;Patient-Focused Outcomes;Patients;Phase;phase 1 study;phase I trial;Phase I/II Trial;phase II trial;Physical Performance;Porfimer Sodium;pre-clinical;primary endpoint;Process;programmed cell death ligand 1;Progression-Free Survivals;PUVA Photochemotherapy;Quality of life;Radiation therapy;Randomized;Reporting;Research Proposals;response;Roentgen Rays;Safety;safety testing;secondary endpoint;standard of care;Stents;success;Testing;Toxic effect;transmission process;Treatment outcome;treatment planning;tumor;tumor ablation;Tumor Immunity;tumor microenvironment;Tumor Oxygenation

PROJECT_TITLE: Interstitial Photodynamic Therapy Following Palliative Radiotherapy for Patients with Inoperable Malignant Central Airway Obstruction

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases;Nutrition;Orphan Drug;Prevention;Rare Diseases;Tuberculosis

ORG_CITY: STONY BROOK

ORG_DEPT: PHARMACOLOGY

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

PHR: Project Narrative The research is this proposal is relevant to public health because understanding pathways essential for the growth and survival of mycobacteria is a necessary first step in developing new therapeutics for and combatting antibiotic resistance in mycobacterial diseases, including tuberculosis. Thus, the proposed work is relevant to the NIAID mission, which includes supporting basic research toward improved understanding, treatment, and prevention of infectious diseases.

PI_NAMEs: SEELIGER, JESSICA CHUANG (contact)

PROGRAM_OFFICER_NAME: ROBINSON, RICHARD THOMAS

PROJECT_TERMS: 2019-nCoV;Aerosols;Affect;Anabolism;Antibiotic Resistance;Antigens;Antitubercular Agents;Attenuated Vaccines;Basic Science;Biological Assay;Cause of Death;Communicable Diseases;CRISPR interference;Data;Disease;Disease Progression;Drug Targeting;effective therapy;enzyme biosynthesis;Gene Expression;Generations;Genes;Genetic Engineering;Genus Mycobacterium;Growth;Histopathology;Homologous Gene;human pathogen;Immune response;Immunity;immunogenicity;improved;In Vitro;in vivo;Infection;Infectious Agent;knock-down;Knowledge;Libraries;Measures;Metabolism;Mission;mouse model;Mucous Membrane;mutant;mycobacterial;Mycobacterium tuberculosis;National Institute of Allergy and Infectious Disease;novel;novel therapeutics;Organism;pathogen;Pathway interactions;prevent;Prevention;Public Health;Research;Review Literature;rib bone structure;Riboflavin;Supplementation;T-Lymphocyte;Testing;Time;Tuberculosis;tuberculosis treatment;uptake;Vaccines;Work

PROJECT_TITLE: Riboflavin biosynthesis and utilization in Mycobacterium tuberculosis

STUDY_SECTION: PCMB

STUDY_SECTION_NAME: Prokaryotic Cell and Molecular Biology Study Section[PCMB]


NIH_SPENDING_CATS: Cancer;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Hepatitis;Liver Cancer;Liver Disease;Nutrition;Prevention;Rare Diseases

ORG_CITY: MANHASSET

ORG_NAME: FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH

PHR: NARRATIVE Patients with severe fatty liver disease-non-alcoholic steatohepatitis (NASH) are at higher risk for adverse hepatic outcomes, including scarring of the liver and liver cancer. In this application, we propose to examine potentially critical cell signaling pathways (Sirtuin and TGF-β) and their roles in liver inflammation, and cancer development. Our study will provide critical new insights and potential treatment targets for fatty liver disease, and liver cancer.

PI_NAMEs: MISHRA, LOPA  (contact)

PROGRAM_OFFICER_NAME: XU, WANPING

PROJECT_TERMS: Acetaminophen;Acetylation;Affect;Binding Proteins;Cells;Chemicals;Cicatrix;Complex;Deacetylase;Deacetylation;Development;Diet;Disease;Epigenetic Process;Event;Fatty Liver;fatty liver disease;Fibrosis;Genes;Genetic Transcription;Heart;Hepatic;Hepatocyte;High Fat Diet;high risk;high risk population;Homeostasis;Human;Human Pathology;Impairment;Individual;Infiltration;Inflammation;insight;Knock-out;Knockout Mice;lipid biosynthesis;Lipids;Liver;Liver diseases;Liver Fibrosis;liver inflammation;liver injury;liver transplantation;Macrophage;MADH2 gene;MADH3 gene;Malignant neoplasm of gastrointestinal tract;Malignant neoplasm of liver;Malignant Neoplasms;Mediating;member;metaplastic cell transformation;Microfluidics;Molecular Target;Mus;mutant;Mutant Strains Mice;Mutation;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;obesity prevention;Outcome;overexpression;Pathway interactions;Patients;Phenotype;Play;Population;preclinical evaluation;Predisposition;prevent;Primary carcinoma of the liver cells;promoter;Proteins;Regulation;Research;Response Elements;Risk Reduction;Role;Signal Pathway;Signal Transduction;Sirtuins;Site;Small Interfering RNA;Spectrin;Steatohepatitis;Sterols;therapeutic target;Tissues;transcription factor;Transforming Growth Factor beta;Treatment Efficacy;Tumor Promotion;Tumor Suppression;Tumor Suppressor Proteins;Waiting Lists;western diet

PROJECT_TITLE: Cellular interactions between TGF-beta pathway members and epigenetic regulators in liver and gastrointestinal cancers

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


NIH_SPENDING_CATS: Cancer;Genetics;Lung;Lung Cancer

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE The development of acquired resistance to EGFR-targeted cancer is a key clinical obstacle in the treatment of lung cancer and hence, strategies to effectively delay and/or overcome acquired resistance are highly desirable and urgently needed in the clinic. We are particularly interested in revealing the mechanisms underlying the acquired resistance through fully understanding the biology of EGFR inhibitors in sensitive and resistant cells or tumors. This proposal will primarily focus on the critical roles of hTERT/telomerase modulation in EGFR-targeted cancer therapy and on developing effective strategies to delay and overcome acquired resistance through targeting hTERT/telomerase or telomere.

PI_NAMEs: SUN, SHI-YONG  (contact)

PROGRAM_OFFICER_NAME: FORRY, SUZANNE L

PROJECT_TERMS: Accounting;Adult;Antineoplastic Agents;Apoptosis;Area;Biological;Biology;c-myc Genes;cancer cell;Cancer cell line;Cancer Patient;cancer therapy;Cell Differentiation process;Cell Line;Cells;Chemicals;Clinic;Clinical;clinical efficacy;Complex;Data;Development;Disease Progression;Ectopic Expression;Epidermal Growth Factor Receptor;Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor;Eukaryotic Cell;Event;FDA approved;Generations;genetic approach;Genetic Suppression;Human;In Vitro;in vivo Model;interest;Invaded;knock-down;Link;Location;lung cancer cell;Malignant neoplasm of lung;Malignant Neoplasms;Mediating;Messenger RNA;Modernization;Molecular;mutant;Mutation;Names;Neoplasm Metastasis;Non-Small-Cell Lung Carcinoma;overexpression;Patients;Pharmaceutical Preparations;prevent;Promoter Regions;Protein Subunits;Proteins;Relapse;Resistance;resistance mutation;response;Ribonucleoproteins;RNA;RNA-Directed DNA Polymerase;Role;Safety;Subgroup;success;targeted cancer therapy;targeted treatment;Telomerase;Telomerase inhibition;Telomerase Inhibitor;telomere;Telomere Maintenance;Testing;Therapeutic;therapeutically effective;Tissues;transcriptome sequencing;Treatment Efficacy;Treatment Failure;tumor;uncontrolled cell growth

PROJECT_TITLE: Targeting hTERT/telomerase for managing acquired resistance to third generation EGFR-TKIs in lung cancer

STUDY_SECTION: MCTC

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics C Study Section [MCTC]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_CITY: DALLAS

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: PROJECT NARRATIVE The pattern in which neurons are interconnected is a powerful determinant of how the brain functions, and experience-dependent changes in these connection patterns likely underlie learning and memory. However, the fundamental rules that link circuit connectomes to information processing are unknown, and it is unclear how activity during experience specifically modifies the connectivity within a neural network to allow memories to be later retrieved or how this process is pathologically altered in human neurological disorders. This research will identify the relationship between connection patterns at the cellular level and network function at the circuit level to reveal fundamental principles that govern information processing, memory formation, and retrieval.

PI_NAMEs: PFEIFFER, BRAD E (contact);VOLK, LENORA J

PROGRAM_OFFICER_NAME: DAVID, KAREN KATE

PROJECT_TERMS: Acute;Architecture;Area;Behavior;Body Weight Changes;Brain;Brain region;Cells;Chronic;Cognitive;Complex;Computer Analysis;connectome;Data;density;Distant;Electrophysiology (science);Environment;experience;Experimental Models;flexibility;Future;Generations;Goals;Hippocampus;Human;in vivo;information processing;Knowledge;Label;Learning;Link;Location;Maps;Measures;Memory;memory consolidation;memory process;memory retrieval;Methods;Modeling;Molecular;Nervous System Disorder;neural;neural network;Neurons;Neurosciences Research;novel;Optics;Pathologic;Pattern;Physiological;place fields;Play;Population;Process;Recurrence;Research;Rest;Retrieval;Role;self organization;sensory input;sensory stimulus;Sleep;Slice;spatial memory;Synapses;synaptic function;Synaptic plasticity;System;Testing;Time;virtual;Weight;Work

PROJECT_TITLE: Investigating reciprocal interactions between circuit and synaptic function

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 ICN-W (55)]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Genetics;Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects;Prevention;Social Determinants of Health;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Public Health Relevance Aging is a risk factor for many chronic conditions including Alzheimer’s disease related dementias (ADRD) and impacts patient outcomes after traumatic brain injury (TBI). Aging can be chronologic aging (time since birth) or biological aging that may differ substantially from chronological age for some individuals. Another risk factor in addition to aging for ADRD is TBI particularly severe TBI. This project brings together epigenetic aging and TBI by investigating the effect of epigenetic age acceleration present acutely after TBI on patient outcomes after severe TBI. This knowledge could assist in improving long term outcomes for individuals who have suffered a severe TBI including mitigating risk of ADRD.

PI_NAMEs: CONLEY, YVETTE P (contact)

PROGRAM_OFFICER_NAME: FENG, LI REBEKAH

PROJECT_TERMS: accelerated epigenetic aging;Acute;Address;Adult;Age;age acceleration;age related;Aging;Algorithms;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Area;behavioral outcome;biological age;Biological Aging;Biological Markers;Birth;Blood;Brain;Brain Injuries;Brain-Derived Neurotrophic Factor;Caring;Central Nervous System;Cerebrospinal Fluid;Chronic;Chronic Phase;Chronology;Clinical Data;Cognition;Cognitive;Cognitive aging;cohort;Data;Deceleration;Dementia;demographics;deprivation;Disparity;DNA;DNA Methylation;early life adversity;Educational Status;Emotional;Epigenetic age;epigenetic aging;epigenetic clock;epigenetic variation;Evidence based intervention;Future;Genes;Healthcare;healthspan;Hour;improved;indexing;Individual;Injury;Intellectual functioning disability;Intervention;Investigation;Knowledge;Life Style;Link;long-term sequelae;Maintenance;Measures;mixed dementia;Monitor;Neighborhoods;Neurodegenerative Disorders;Neurodevelopmental Disorder;Neurons;neuropathology;Older Population;Outcome;Participant;Pathway interactions;patient biomarkers;Patient Outcomes Assessments;patient population;Patient-Focused Outcomes;Patients;peripheral blood;Phase;Phenotype;Population;Preschool Child;Process;prognostication;Promoter Regions;public health relevance;Recovery;Research;Risk;Risk Factors;risk mitigation;Role;Sample Size;Sampling;Serum;severe injury;social deprivation;social factors;social health determinants;Specimen;Stress;TBI Patients;therapy development;Time;Tissues;Traumatic Brain Injury;Traumatic Brain Injury recovery;whole genome;Work

PROJECT_TITLE: Epigenetic Age and Patient Outcomes after Severe Traumatic Brain Injury

STUDY_SECTION: AIMR

STUDY_SECTION_NAME:
Aging, Injury, Musculoskeletal, and Rheumatologic Disorders Study
Section[AIMR]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Social Determinants of Health

ORG_CITY: PHILADELPHIA

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE Public policies are crucial tools for influencing consumer behaviors and health outcomes. This study will develop novel causal approaches for estimating the effect of public policies under complex real-world settings such as spillover, substitution, and sociodemographic and geographic diversity. These new causal approaches will be used to assess the effect of the Philadelphia beverage tax on consumer purchasing behaviors, consumption, and individual-level health outcomes and provide guidance to policymakers designing future policies in different demographic and contextual settings.

PI_NAMEs: MITRA, NANDITA  (contact)

PROGRAM_OFFICER_NAME: EVANS, MARY

PROJECT_TERMS: Accounting;Address;Adolescent Risk Behavior;Affect;Behavior;Beverages;Body mass index;Calories;Cannabis policy;Characteristics;Chronic Disease;Cities;Complex;consumer behavior;Consumption;County;Data;Demographic Factors;design;Disease;Evaluation;flexibility;Food;Food Chain;Future;Gasoline;Geographic Factor;Geography;Goals;Health;Health behavior and outcomes;Health Policy;improved;Individual;Industry;innovation;insight;Intake;interest;Intervention;Knowledge;Lead;Literature;marginalized population;Methods;Natural experiment;Non-Insulin-Dependent Diabetes Mellitus;novel;nutrition;Nutritional;Obesity;Outcome;Philadelphia;Policies;Policy Analysis;Policy Maker;Population;prevent;Price;Public Health;Public Policy;Recreation;Research Personnel;response;Sales;San Francisco;semiparametric;sociodemographics;soft drink;software development;Specific qualifier value;sugar;Surveys;sweetened beverage;System;Taxes;tool;Underserved Population;user friendly software;Variant;Weight;Work

PROJECT_TITLE: Causal effect estimation of public policies on purchasing behaviors, consumption and health outcomes

STUDY_SECTION: ASPB

STUDY_SECTION_NAME: Analytics and Statistics for Population Research Panel B Study Section[ASPB]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

ORG_CITY: WEST LAFAYETTE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: Project Narrative The proposal is to develop extremely large-scale neural imaging technologies, which will enable cellular resolution functional imaging deep in the mammalian brain with unprecedented signal levels and spatial scales.

PI_NAMEs: CUI, MENG  (contact);KOMIYAMA, TAKAKI

PROGRAM_OFFICER_NAME: PUCAK, MICHELE LYNN

PROJECT_TITLE: Light pipe microscope for ultra-large-scale cellular-resolution whole-neocortex two-photon calcium imaging of mammalian brains

STUDY_SECTION: NSD

STUDY_SECTION_NAME: Neurological Sciences and Disorders D Study Section[NSD-D]


NIH_SPENDING_CATS: Biotechnology;Gene Therapy;Genetics

ORG_CITY: DURHAM

ORG_DEPT: SURGERY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Narrative The current proposal focuses on studying AAV capsid-genome interactions and the impact on transcription. We will investigate how AAV structure regulates epigenetic signatures on the genome and controls transcriptional activity of vector genomes across different species. Overall, we expect to develop a roadmap for improving AAV vector design, thereby improving therapeutic efficacy and safety of AAV gene therapies.

PI_NAMEs: ASOKAN, ARAVIND  (contact)

PROGRAM_OFFICER_NAME: LACHOWICZ-SCROGGINS, MARRAH ELIZABETH

PROJECT_TERMS: adeno-associated viral vector;Advisory Committees;Affect;base editor;Biodistribution;Biology;Capsid;Capsid Proteins;Clinical;clinical translation;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;Communication;Dependovirus;design;dosage;Dose;Engineering;EP300 gene;Epigenetic Process;Evolution;Family suidae;Funding;Future;Gene Expression;Gene Expression Profile;gene therapy;Gene Transfer;Genetic Recombination;Genetic Transcription;Genome;genome editing;Goals;Hepatic;histone modification;Immune;immunogenicity;improved;in vivo;Integration Host Factors;Intravenous;Kidney;Libraries;Liver;Macaca;Macaca mulatta;Maps;Mediating;Medical;meetings;Modeling;Monkeys;mouse model;Mus;mutant;Mutation;Nature;nonhuman primate;novel;pre-clinical;Rare Diseases;Reporter Genes;Reporting;Repression;Role;Safety;Serious Adverse Event;Serotyping;stem;Structure;System;Therapeutic;therapeutic gene;thrombotic;Tissues;Toxic effect;trait;Transcript;Transcriptional Regulation;transduction efficiency;transgene expression;Transgenic Mice;Transgenic Organisms;Translating;Treatment Efficacy;Tropism;United States Food and Drug Administration;Variant;vector;vector control;vector genome;virus tropism;Work

PROJECT_TITLE: Determinants of AAV Tropism

STUDY_SECTION: DBTD

STUDY_SECTION_NAME: Drug and Biologic Therapeutic Delivery Study Section[DBTD]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Genetics;Human Genome;Immunotherapy;Infectious Diseases;Orphan Drug;Rare Diseases;Sexually Transmitted Infections

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

PHR: Project Narrative: We aim to elucidate the mechanistic determinants underlying immune checkpoint inhibitor (ICI) responsiveness vs. resistance in HPV+ HNSCCs and better understand whether anti-HPV immune responses contribute to ICI efficacy. Completion of our studies will lay a scientific foundation for developing novel therapies for HPV+ HNSCCs by recapitulating the effective T cell receptor (TCR) clonotypes and elucidating a fundamental link between immunological heterogeneity and highly variable anti-tumor responses.

PI_NAMEs: FERRIS, ROBERT L.;WANG, JING HONG (contact)

PROGRAM_OFFICER_NAME: ZAMISCH, MONICA

PROJECT_TERMS: Adjuvant Study;Affect;Aftercare;anti-CTLA4;anti-PD-1;anti-PD-L1 therapy;anti-tumor immune response;Antibodies;Antigens;Antitumor Response;Biological Assay;CD8-Positive T-Lymphocytes;cell killing;Cell Therapy;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Clinical;Clinical Trials;Clonal Expansion;Coupled;detection platform;efficacy testing;Enrollment;Epitopes;Excision;Foundations;Frequencies;Future;Genes;Goals;Head and Neck Squamous Cell Carcinoma;Heterogeneity;Human;Human papilloma virus infection;Human Papillomavirus;Human papillomavirus 16;Immune;Immune checkpoint inhibitor;Immune response;Immunologics;Incidence;Individual;Institution;Link;Mediating;Modeling;mouse model;Mus;Neoadjuvant Therapy;Nivolumab;novel;novel therapeutics;Operative Surgical Procedures;oral HPV-positive head and neck cancers;Outcome;Pathogenicity;Pathway interactions;Patients;Peptides;Phenotype;Publishing;Reaction;Recurrence;Reporter;Resectable;Resistance;responders and non-responders;response;Sampling;single-cell RNA sequencing;Specimen;T cell receptor repertoire sequencing;T-Cell Activation;T-Cell Receptor;T-Lymphocyte;Testing;transcriptome;transcriptomics;Transplantation;treatment response;tumor;Tumor-Infiltrating Lymphocytes;Validation

PROJECT_TITLE: Mechanistic connection between HPV-specific TCRs and therapeutic responses to ICI in HPV+ HNSCC

STUDY_SECTION: CONC

STUDY_SECTION_NAME: Clinical Oncology Study Section[CONC]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Prostate Cancer;Urologic Diseases

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative Neuroendocrine prostate cancer (NEPC) is the most lethal form of the disease. However, a detailed understanding of mechanisms that contribute to NEPC development and progression is unknown, and there are no effective therapies. This proposal is designed to determine how loss of key tumor suppressor genes reprograms prostate epithelial cells and to determine how a new, combinatorial treatment strategy blocks NEPC cell survival so we may initiate clinical trials.

PI_NAMEs: ALUMKAL, JOSHI JAMES (contact)

PROGRAM_OFFICER_NAME: KONDAPAKA, SUDHIR B

PROJECT_TERMS: Androgen Receptor;Azacitidine;Binding;bisulfite sequencing;Bromodomains and extra-terminal domain inhibitor;cancer cell;Cell Survival;Cells;Chromatin;chromatin immunoprecipitation;Clinic;Clinical;Clinical Trials;combinatorial;Combined Modality Therapy;Complex;CRISPR interference;demethylation;design;Development;Differentiated Gene;Disease;DNA;DNA Methylation;DNA methyltransferase inhibition;DNA Methyltransferase Inhibitor;DNA Modification Methylases;DNMT3a;DNMT3B gene;E2F transcription factors;effective therapy;Epigenetic Process;Epithelial Cells;epithelial to mesenchymal transition;Epithelium;EZH2 gene;Future;Gene Expression;gene repression;Gene Silencing;Genes;Genetic Transcription;Genomic Segment;Growth;Histology;histone methylation;Histones;Homeostasis;In Vitro;in vivo;Induced Neurons;inhibitor;loss of function;Malignant neoplasm of prostate;Malignant Neoplasms;Measures;member;men;Mesenchymal;Modeling;Molecular;Mus;mutant;Neoplasm Metastasis;neuroendocrine differentiation;Neuroendocrine Prostate Cancer;Neuronal Differentiation;Neurons;Normal Cell;novel;novel therapeutic intervention;overexpression;Pathway interactions;patient subsets;Patients;Pharmaceutical Preparations;pharmacologic;Phase I Clinical Trials;pluripotency;Predisposition;prevent;programs;Prostate;prostate cancer cell;Protein Methyltransferases;Proteins;RB1 gene;Reader;Receptor Signaling;recruit;Repression;Repressor Proteins;Resistance;resistance mechanism;response biomarker;RNA Interference;Safety;scaffold;single-cell RNA sequencing;targeted treatment;Testing;therapeutically effective;therapy resistant;Toxic effect;TP53 gene;Transcription Coactivator;transcription factor;Transcription Repressor;transcriptome sequencing;Translating;treatment strategy;tumor;tumor growth;tumor progression;Tumor Suppressor Genes;Tumor Suppressor Proteins;Virulent;Work

PROJECT_TITLE: Developing New Treatment Strategies for Neuroendocrine Prostate Cancer

STUDY_SECTION: ATA

STUDY_SECTION_NAME:
Advancing Therapeutics A Study Section
[ATA]


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric

ORG_CITY: RICHARDSON

ORG_NAME: UNIVERSITY OF TEXAS DALLAS

PHR: PROJECT NARRATIVE About 2.05 million children in the US are diagnosed with autism, and the majority of them do not achieve language outcomes within the typical range even when they receive timely early intervention. Given the strong link between early vocabulary and later language outcomes, this project seeks to understand whether autistic children can learn novel words from infant-directed speech, a common way language input is provided to young children. The project is relevant to NIH and NIDCD’s mission as findings have the potential to provide insights into the type of language input that fosters language development in autistic children and inform parent-training intervention programs for autistic children.

PI_NAMEs: SU, PUMPKI LEI (contact)

PROGRAM_OFFICER_NAME: STORKEL, HOLLY LYNN

PROJECT_TERMS: Acoustics;Adult;Affect;Age;aged;Attention;Auditory;autism spectrum disorder;autistic;autistic children;Caregivers;Characteristics;Child;Clinical;Data;Diagnosis;Early Intervention;educational atmosphere;Educational process of instructing;Environment;Eye;Fostering;Future;gaze;Goals;improved;Individual;Infant;insight;interest;Intervention;intervention program;Language;Language Development;language outcome;Learning;Link;Loudness;Measures;Mission;Modeling;Motivation;multimodality;National Institute on Deafness and Other Communication Disorders;novel;Outcome;parenting intervention;Participant;peer;Population;Process;Quality of life;Questionnaires;Research;response;Sensory;social;social communication;Social Environment;Social Interaction;Social outcome;Specific qualifier value;Speech;Stimulus;Testing;Training;United States National Institutes of Health;Variant;Vocabulary;word learning;Work

PROJECT_TITLE: Word Learning from Infant-Directed Speech in Autistic Children


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Neurosciences;Serious Mental Illness

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE Cognitive behavioral therapy (CBT) is the most effective psychological treatment for anxiety and obsessive compulsive related disorders, yet approximately half of patients with these disorders who receive CBT fail to achieve sustained clinical remission. No reliable biomarker of CBT non-response exists. This study will determine whether early changes in a specific biomarker, self-focused attention, will represent a sensitive predictor and potential mechanism of CBT non-response.

PI_NAMEs: FANG, ANGELA  (contact)

PROGRAM_OFFICER_NAME: TALKOVSKY, ALEXANDER MAXWELL

PROJECT_TERMS: Accounting;Address;Aftercare;alternative treatment;Anxiety;anxiety treatment;Attention;attentional control;Behavioral;Biological Assay;Biological Markers;Body Dysmorphic Disorder;Brain;Classification;Clinical;clinical application;clinical remission;Cognitive;Cognitive Therapy;cohort;comparison control;Data;Data Set;Diagnostic;Disease;Dorsal;Emotional;Exhibits;Failure;Feeling;frontier;Functional Magnetic Resonance Imaging;Future;Goals;Grant;improved;Individual;Individual Differences;Intervention;K-Series Research Career Programs;Link;Machine Learning;machine learning model;machine learning prediction;Magnetic Resonance Imaging;Measurement;Measures;Mental Health;Modeling;Modification;MRI Scans;multimodality;neural;Neurobiology;Neurocognitive;neuroimaging;Obsessive compulsive behavior;Obsessive-Compulsive Disorder;Occupations;outcome prediction;Patient Self-Report;patient subsets;Patients;physical state;predicting response;Process;Proxy;psychologic;Public Health;Recommendation;Research;response;Rest;Risk;rumination;Sampling;Selection for Treatments;Severities;Social Anxiety Disorder;specific biomarkers;stability testing;Subgroup;supervised learning;Symptoms;System;Techniques;Testing;Thinking;Time;trait;Translating;treatment planning;treatment response;Validity and Reliability

PROJECT_TITLE: Contributions of Self-Focused Attention to Early Warning Indicators of CBT Non-Response

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


ORG_NAME: JOSLIN DIABETES CENTER

PHR: PROJECT NARRATIVE The mechanisms and pathways that operate during the onset and progression of obesity and type 2 diabetes (T2D) are not fully understood. We will take advantage of emerging observations that modifications on ribonucleic acids (RNA) functionally impact metabolic tissues and recent development of enabling methods that sequence RNA modifications with base resolution precision. We seek to map and investigate functionally important RNA modifications in metabolic cells from humans with obesity and type 2 diabetes with the long- term goal of gaining new insights into the pathophysiology of this chronic disease.

PI_NAMEs: CHEN, MENGJIE ;HE, CHUAN ;KERN, PHILIP A;KULKARNI, ROHIT N. (contact);NAJI, ALI

PROGRAM_OFFICER_NAME: BLONDEL, OLIVIER

PROJECT_TERMS: Adenosine;Adipocytes;Adipose tissue;Area;ATAC-seq;Automobile Driving;base;Beta Cell;Biological Markers;Blood Cells;Catalogs;Cell Line;Cell Physiology;cell type;Cells;Chemicals;Chromatin;Chronic Disease;Cohort Studies;Communities;comparison control;Coupled;Data;Data Set;Databases;Development;Disease;DNA Methylation;Economic Burden;effective therapy;Enhancers;Epigenetic Process;epigenetic regulation;epigenomics;epitranscriptomics;Etiology;Functional disorder;Future;Gene Expression;Gene Expression Regulation;Generations;Genetic Transcription;Genetic Variation;genome wide association study;Genomics;Goals;histone modification;Human;human tissue;improved;In Vitro;innovation;insight;insulin secretion;interest;invention;Investigation;islet;Islets of Langerhans;Knowledge;Laboratories;Light;Link;lipid biosynthesis;Liver;Maps;Messenger RNA;Metabolic;Metabolic Diseases;Methods;Methylation;Modification;Monitor;mRNA Expression;Muscle Fibers;new therapeutic target;Non-Insulin-Dependent Diabetes Mellitus;novel;obese patients;Obesity;Pathologic;Pathway interactions;Patients;peripheral blood;Post-Transcriptional Regulation;Post-Translational Protein Processing;posttranscriptional;premature;Prevalence;protein expression;Publications;Quantitative Trait Loci;Regulation;Regulatory Pathway;repository;Research;Research Personnel;Resolution;Resources;response;RNA;Role;Sampling;Signal Pathway;Signal Transduction;Skeletal Muscle;stoichiometry;success;Systems Biology;Therapeutic;therapeutic development;Tissue Sample;Tissues;Translational Research;translational therapeutics;treatment response;Validation;Variant;virtual

PROJECT_TITLE: Epitranscriptomics in human obesity and type 2 diabetes

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-1 (J2)]


NIH_SPENDING_CATS: Eczema / Atopic Dermatitis;Infectious Diseases;Neurosciences

PHR: PROJECT NARRATIVE The skin surface serves as a barrier against invading microbes and environmental chemicals. The proposed research will investigate microbial enzymes and host cell signals that disrupt the skin barrier and drive inflammatory responses. The goal of this research is to understand how these enzymes and signals trigger skin inflammation and produce knowledge essential for the development of new therapies for inflammatory skin diseases such as atopic dermatitis.

PI_NAMEs: PARK, JIN MO  (contact)

PROGRAM_OFFICER_NAME: DONG, GANG

PROJECT_TERMS: afferent nerve;Allergens;Allergic;Allergic Disease;Allergic inflammation;Allergic Reaction;analog;Antigens;Atopic Dermatitis;Automobile Driving;Bacteria;Biological Assay;CDH1 gene;cell type;Cells;Chronic;Clinical;computerized tools;Core Facility;Data;Data Set;Development;Disease;environmental allergen;environmental chemical;Enzymes;Epidermis;Epithelial Cells;Epithelium;Etiology;Event;Exhibits;Exposure to;Functional disorder;Gene Expression;Gene Frequency;Genes;genome editing;Genus staphylococcus;glutamyl endopeptidase;Goals;Human;human disease;Hypersensitivity;Immune;Immune system;Immunoglobulins;Immunologic Sensitization;Immunology;Inflammation;Inflammation Mediators;Inflammatory;Inflammatory Response;Interleukin-13;interleukin-22;Invaded;Ion Channel;keratinocyte;Knockout Mice;Knowledge;Link;Lymphocyte;MAPK1 gene;Mediating;metagenome;Microbe;microbial;Modeling;Molecular;Mus;Nerve Endings;Nerve Fibers;nerve supply;Nervous System;Neuroimmune;Neurosecretory Systems;neutralizing antibody;novel therapeutics;Pathogenesis;Pathologic Processes;Pathology;Penetration;Peptide Hydrolases;Piezo 1 ion channel;programs;Protein Kinase;Proteins;Proteolysis;Reaction;Reflex action;Research;Research Personnel;Research Project Grants;response;Role;sensor;Serine Protease;Severities;Shapes;Signal Pathway;Signal Transduction;Skin;skin barrier;Skin colonization;skin disorder;skin microbiome;small molecule inhibitor;staphylococcal protease;Staphylococcus aureus;Surface;T-Lymphocyte;Tissues;tool;Toxic Environmental Substances;transcriptome;transcriptomics;Transducers;Translating

PROJECT_TITLE: Staphylococcal protease-mediated epithelial barrier perturbation and allergen sensitization

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IIDA-F (57)]


ADMINISTERING_IC: TR

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Assistive Technology;Behavioral and Social Science;Bioengineering;Brain Disorders;Disability Research;Down Syndrome;Intellectual and Developmental Disabilities (IDD);Machine Learning and Artificial Intelligence;Pediatric;Rehabilitation

PHR: Supporting mobility at the same age as their peers, can have positive effects on the social, emotional, and even cognitive development of children with Down Syndrome, who typically are delayed in meeting developmental milestones. Our research aims to find out if two specific mobility aids, partial bodyweight support and powered wheelchair that can be used in both sitting and standing positions, are effective in helping young children with Down syndrome develop their mobility skills and engage in play. We will use wearable sensors and machine learning methods to measure if children with Down Syndrome move around more while using the mobility aids and how their bodies respond to the devices.

PI_NAMEs: THOMPSON, HILAIRE J (contact)

PROGRAM_OFFICER_NAME: RADMAN, THOMAS C

PROJECT_TERMS: Age;Age Months;Award;Biomechanics;Body Weight;career development;Caregivers;Child;Child Development;Childhood;cognitive development;Collaborations;Development;Development Plans;Developmental Delay Disorders;Devices;disability;Disabled Children;Doctor of Philosophy;doctoral student;Down's Syndrome;Electromyography;Emotional;Engineering;Ensure;Evaluation;Exploratory Behavior;Fostering;Foundations;Funding;Future;Gait;Growth;Head;Impaired cognition;Interview;Joint Laxity;Lead;machine learning method;Measures;Mechanics;meetings;Mentorship;mobility aid;multidisciplinary;Muscle;Muscle Tonus;National Research Service Awards;Participant;peer;Physical Medicine;Play;Positioning Attribute;Posture;Powered wheelchair;programs;Qualitative Research;Research;Research Personnel;response;Self-Help Devices;skills;social;Technology;Testing;TNFSF15 gene;Training;Translational Research;Translations;Walking;wearable sensor technology

PROJECT_TITLE: NRSA Training Core


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Bioengineering;Biotechnology

ORG_CITY: COLD SPRING HARBOR

ORG_NAME: COLD SPRING HARBOR LABORATORY

PHR: NARRATIVE  Structural biology is the field of science that focuses on understanding the structure, function, and interactions of biological macromolecules, such as proteins and nucleic acids, and their complexes. It involves the use of various experimental techniques, including X-ray crystallography, nuclear magnetic resonance (NMR) spectroscopy, cryo-electron microscopy, and computational modeling to determine the 3D structures of these molecules. The information obtained through structural biology studies can help researchers to understand the molecular mechanisms underlying biological processes including pathogenesis in disease, and can be used to develop new drugs and vaccines by targeting specific molecules and their interactions. This application seeks funds to support the continuation of two laboratory-based short intensive courses on Macromolecular Crystallography and Cryo-Electron Microscopy at Cold Spring Harbor Laboratory, New York. Both courses are designed for scientists with a working knowledge of macromolecular structure and function, but who are new to these twin methodological pillars of structural biology. Trainees include advanced graduate students, postdoctoral researchers and young faculty from throughout the United States and abroad.

PI_NAMEs: STEWART, DAVID J. (contact)

PROGRAM_OFFICER_NAME: MOTEN, CARMEN

PROJECT_TERMS: Academia;Area;Automation;Awareness;Biochemistry;Biological;Biological Process;Biological Products;biological research;Biological Sciences;Biology;Capsid Proteins;career;Communicable Diseases;Complex;Computer Models;Computing Methodologies;Core Facility;Course Content;Cryoelectron Microscopy;cryogenics;Crystallography;data acquisition;Data Analyses;Data Collection;Dedications;design;detector;Development;Discipline;Disease;Disease Progression;Doctor of Medicine;Doctor of Philosophy;Drug Design;drug discovery;educational atmosphere;Educational process of instructing;Educational workshop;electron diffraction;Electron Microscope;Electrons;Ensure;Environment;experience;experimental study;Faculty;Freezing;Funding;Gender;graduate student;Hand;image processing;improved;Industry;Infrastructure;innovation;Instruction;instructor;interest;investigator training;Ion Channel;Knowledge;Laboratories;laboratory curriculum;Learning;lecturer;lectures;Macromolecular Complexes;macromolecule;Maps;medical schools;Membrane Proteins;Mentors;method development;Methodology;Methods;Microscope;Mitochondrial Proteins;model building;Molecular;Molecular Structure;Multienzyme Complexes;Negative Staining;Neuroanatomy;New York;NMR Spectroscopy;Nobel Prize;novel;novel therapeutics;novel vaccines;Nucleic Acids;Onset of illness;Participant;particle;pathogen;Pathogenesis;Pharmaceutical Preparations;Postdoctoral Fellow;power harvesting;Preparation;Principal Investigator;Procedures;Process;programs;protein complex;protein function;protein structure;Proteins;Proteomics;Research;Research Personnel;Resolution;Resources;Ribosomes;Roentgen Rays;Sampling;Science;Scientist;Senior Scientist;Series;small molecule;Source;Specimen;Stains;stem;structural biology;Structure;Students;Synchrotrons;Talents;Techniques;Technology;theories;Therapeutic antibodies;three dimensional structure;Titan;tomography;Training;translational approach;Twin Multiple Birth;Underrepresented Minority;United States;Universities;Update;vaccine-induced antibodies;Validation;Virus;Work;X-Ray Crystallography;x-ray free-electron laser;Yeasts

PROJECT_TITLE: CSHL Structural Biology Short Courses in Crystallography & Cryo-Electron Microscopy

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 PP-D (M1)]


NIH_SPENDING_CATS: Asthma;Health Effects of Indoor Air Pollution;Immunotherapy;Lung

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

PHR: Project Narrative Asthma is an inflammatory disease of the airways that affects more than 300 million people worldwide and is increasing in incidence. This research will focus on understanding how allergen-specific CD4+ memory T cells that reside in the lung and orchestrate the response to the most common cause of allergic asthma, house dust mite, behave in response to subsequent allergen exposure. These studies will provide novel mechanisms to develop therapies that prevent and inhibit allergen-induced asthma.

PI_NAMEs: PEPPER, MARION  (contact)

PROGRAM_OFFICER_NAME: SUBRAMANIAN, HARIHARAN

PROJECT_TERMS: Ablation;Acute;Address;Affect;Airway Disease;airway inflammation;Allergens;allergic airway inflammation;Antibodies;Area;associated symptom;Asthma;asthmatic;asthmatic patient;B-Lymphocytes;BCL6 gene;Binding;Blood Vessels;Bone Marrow;CD4 Positive T Lymphocytes;Cells;Characteristics;Clinical;Complex;cytokine;Data;Dermatophagoides pteronyssinus;design;Development;disease model;Disparity population;Dose;Effector Cell;Eragrostis;Exposure to;Extrinsic asthma;Family member;Generations;Genetic Transcription;Genomics;Goals;Helper-Inducer T-Lymphocyte;Heterogeneity;Human;IgE;Immune Targeting;immunopathology;immunoregulation;Immunotherapy;Incidence;inducible Cre;Inflammation;Inflammatory;Influenza;innovation;interest;Interleukin-1;Interleukin-10;Interleukin-13;Interleukin-2;interleukin-21;Interleukin-4;Interleukin-5;Knockout Mice;Knowledge;Learning;Location;LoxP-flanked allele;Lung;Lymphoid;lymphoid organ;magnetic beads;Maintenance;Measurable;Mediating;Memory;memory CD4 T lymphocyte;Methods;Microscopy;migration;Modeling;Molecular;mouse model;Mus;novel;Pathogenesis;Pathologic;Pathology;Peptide/MHC Complex;Peptides;Persons;Phenotype;Population;Population Heterogeneity;prevent;Process;Production;progenitor;programmed cell death protein 1;programs;Proteins;Pyroglyphidae;receptor;Recurrence;Reporter;Research;Resolution;response;Signal Transduction;Structure of parenchyma of lung;System;T-Cell Receptor;Techniques;Th1 Cells;Th2 Cells;Therapeutic;therapy development;Time;Tissues;tool;transcription factor

PROJECT_TITLE: The Differentiation and Function of heterogeneous populations of Allergen-specific Lung-resident Th2 CD4+ memory cells


NIH_SPENDING_CATS: Aging;Brain Disorders;Clinical Research;Dental, Oral, and Craniofacial Disease;Down Syndrome;Intellectual and Developmental Disabilities (IDD)

PHR: Individuals with Down syndrome develop oral inflammatory diseases, like gingivitis and periodontitis, at an accelerated rate. Despite the knowledge that oral inflammation and other co-occurring conditions are accelerated with age, there are a lack of studies attempting to investigate or target the underlying biology of age. This proposal investigates whether inflammaging, a low-grade chronic inflammation during age, is hyperactive in the gingival tissues of individuals with DS, all while completing an updated epidemiological inquiry on the current oral health landscape in individuals with DS, and a basic scientific inquiry into whether existing DS mice models can mimic accelerated oral inflammation. The proposal stands to enable the pursuit of an innovative strategy to improve oral health in people with DS by targeting aging biology, all while training a dentist-scientist to develop as an independent investigator to conduct rigorous clinical and translational research career in DS-related research.

PI_NAMEs: MCKINNEY, CHRISTY MICHELLE (contact)

PROJECT_TERMS: Acceleration;Address;Adult;Age;Award;Biology;Biology of Aging;career;career development;Child;Chronic;Clinical;Clinical and Translational Science Awards;Clinical Research;Collaborations;Communities;Dental;Dentists;Development;Disease;Down's Syndrome;early-career faculty;Epidemiology;Funding;Future;Gingiva;Gingivitis;healthspan;High Prevalence;Human;human old age (65+);Hyperactivity;Immunology;improved;Individual;Inflammaging;Inflammation;Inflammatory;innovation;Institution;K-Series Research Career Programs;Knowledge;Mentors;mouse model;Mucous Membrane;National Center for Advancing Translational Sciences;National Heart, Lung, and Blood Institute;National Institute of Allergy and Infectious Disease;National Institute of Dental and Craniofacial Research;novel;Oral;Oral health;Periodontitis;Persons;Phenotype;programs;Research;Research Activity;Research Personnel;Resources;Role;School Dentistry;Scientific Inquiry;Scientist;single cell analysis;Site;Time;Tissues;Training;translational health science;Translational Research;United States National Institutes of Health;Universities;Update;Wages;Washington;Work

PROJECT_TITLE: Institutional Career Development Core


NIH_SPENDING_CATS: Breast Cancer;Cancer;Clinical Research;Colorectal Cancer;Digestive Diseases;Genetic Testing;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Immunotherapy;Orphan Drug;Precision Medicine;Prevention;Rare Diseases;Social Determinants of Health;Women's Health Research

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: Project Narrative: The growing use of genetic testing across adult cancer diagnoses is driving the development of precision oncology: a new paradigm for personalizing cancer treatment and prevention based on genetic testing results. We pioneered the Georgia-California Genetic Testing Linkage Initiative, which linked industry-provided germline genetic testing data to Surveillance, Epidemiology and End Results program cancer registry records, and are now markedly expanding the initiative to include all adults diagnosed with cancer in Georgia and California from 2013-23 and genetic testing results through 2025. We will use this unique data infrastructure to determine whether the management of genetic testing results is effectively personalized to patient clinical factors and whether cancer mortality varies by genetic testing results, across cancer types.

PI_NAMEs: KATZ, STEVEN J.;KURIAN, ALLISON W. (contact)

PROGRAM_OFFICER_NAME: FILIPSKI, KELLY

PROJECT_TERMS: Address;Adult;advanced prostate cancer;Automobile Driving;Biological Markers;BRCA1 gene;BRCA2 gene;Breast;California;Cancer Control;cancer diagnosis;Cancer Patient;cancer prevention;cancer subtypes;cancer therapy;cancer type;chemotherapy;Clinical;Colorectal;Colorectal Cancer;Communication;comorbidity;curative treatments;Data;data infrastructure;Data Linkages;Development;Diagnosis;Diffusion;disease-causing mutation;Disparity;Early treatment;Endometrial;Endometrial Carcinoma;Estrogen receptor positive;ethnic minority population;Ethnic Origin;Excision;Female Breast Carcinoma;Genes;Genetic;genetic testing;Germ Lines;Guidelines;Healthcare Systems;Hereditary Nonpolyposis Colorectal Neoplasms;Immune checkpoint inhibitor;Immunotherapy;Income;individualized prevention;Industry;Inherited;inhibitor;Insurance;Integration Host Factors;Intervention;Link;Male mammary gland;Malignant Breast Neoplasm;Malignant neoplasm of ovary;Malignant neoplasm of pancreas;Malignant neoplasm of prostate;Malignant Neoplasms;maltreatment;Measures;Mismatch Repair Deficiency;mortality;neoplasm registry;Operative Surgical Procedures;Organ Preservation;Outcome;outcome disparities;Ovarian;Patients;personalized cancer therapy;personalized medicine;Pharmaceutical Preparations;Phase;Poly(ADP-ribose) Polymerase Inhibitor;Population;population based;precision genetics;precision oncology;Prognosis;Prostate;Quality of Care;Race;racial minority population;Recommendation;Records;Registries;Research;SEER Program;Socioeconomic Status;socioeconomics;Solid Neoplasm;Systemic Therapy;targeted cancer therapy;targeted treatment;Test Result;Testing;tumor;Update;Uterus;variant of unknown significance;virtual;Work

PROJECT_TITLE: Personalizing genetic test results management and outcomes after diagnosis of cancer: the Georgia-California SEER Genelink Study

STUDY_SECTION: ODHS

STUDY_SECTION_NAME: Organization and Delivery of Health Services Study Section[ODHS]


NIH_SPENDING_CATS: Cardiovascular;Rare Diseases

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Project Narrative MIF is a prognostic biomarker of human CVD, including AAA, and a pleotropic cytokine that promotes CVD development. The discovery of CD74 as the MIF receptor suggests the requirement of more than one MIF receptor. During the search for novel MIF receptors, we found that the “airway epithelial cell-specific” chloride channel accessory protein-1 (CLCA1) acts as decoy MIF endogenous inhibitor that may help slow AAA growth by blocking MIF inflammatory activity.

PI_NAMEs: LIBBY, PETER  (contact)

PROGRAM_OFFICER_NAME: CHARETTE, MARC F

PROJECT_TERMS: Abdominal Aortic Aneurysm;Active Sites;Affect;airway epithelium;Angiotensin II;Aorta;Aortic Diseases;Apolipoprotein E;Atherosclerosis;Binding;Binding Proteins;Biological Assay;Blood Vessels;C-terminal;Cathepsins;CD44 gene;Cell Physiology;cell type;Cells;chemokine;chemokine receptor;Chloride Channels;Complementary DNA;Complex;CXCR4 gene;cytokine;Cytoplasmic Tail;Development;Endogenous Factors;Endosomes;Epithelial Cells;experimental study;Fibronectins;Golgi Apparatus;Growth;Human;Inflammatory;Infusion procedures;inhibitor;Injury;Interleukin-8B Receptor;invariant chain;Ions;Knock-in;Knock-in Mouse;Length;Lesion;Lysosomes;Macrophage;Mediating;Migration Inhibitory Factor;Molecular Chaperones;Mucins;Mus;mutant;Mutation;N Domain;N-terminal;Nature;novel;Pathogenicity;Peptide Hydrolases;Peptides;Plasma;Process;Prognostic Marker;Proteins;Proteomics;receptor;Recombinant Proteins;Recombinants;Reporting;Respiration Disorders;Role;screening;Signal Transduction;Site;Smooth Muscle Myocytes;Testing;Time;Transportation;Vascular Smooth Muscle;von Willebrand Factor

PROJECT_TITLE: Role of CLCA1 as a MIF decoy inhibitor in abdominal aortic aneurysms

STUDY_SECTION: AVI

STUDY_SECTION_NAME: Atherosclerosis and Vascular Inflammation Study Section[AVI]


NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Nutrition;Obesity;Pediatric;Prevention

ORG_CITY: HANOVER

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: PROJECT NARRATIVE Our goal for this project is to disentangle the longitudinal associations between genetic obesity risk factors, parental feeding practices, child obesogenic appetitive traits and adiposity gain during the preschool years. Through repeated measurements from 2.5 through 5 years of age, this research will advance our understanding of the etiology of child obesity to guide future targeted obesity prevention efforts.

PI_NAMEs: EMOND, JENNIFER A. (contact);GILBERT-DIAMOND, DIANE IHN AE

PROGRAM_OFFICER_NAME: OSGANIAN, VOULA

PROJECT_TERMS: 5 year old;Age;aged;Area;attentional bias;Behavioral;Body mass index;Child;Child Rearing;cohort;Complex;Consumption;Data;design;Desire for food;Development;Dietary intake;early childhood;Eating;Eating Behavior;eating in absence of hunger;Emotional;Emotions;Enrollment;Etiology;Exhibits;Family;feeding;Food;food avoidance;Future;Genetic;Genetic Predisposition to Disease;Genetic Risk;genetic risk factor;Goals;Healthy Eating;Heterogeneity;Hyperphagia;Informal Social Control;Intake;Intervention;Life;lifetime risk;Longitudinal Studies;Measurement;Measures;Mediating;Mediation;Modeling;Modification;Needs Assessment;Neurobiology;novel;novel strategies;Nursery Schools;Obesity;obesity genetics;obesity in children;obesity prevention;obesity risk;obesogenic;Parents;polygenic risk score;Predisposition;Prevention program;prospective;prospective test;Research;Research Design;response;Risk Factors;Shapes;Single Nucleotide Polymorphism;skills;Stimulus;Testing;theories;Time;trait;visual tracking;Work

PROJECT_TITLE: Characterizing the relationships of genetic risk and parental coercive feeding practices with appetitive traits and adiposity gain across early life.

STUDY_SECTION: LHB

STUDY_SECTION_NAME: Lifestyle and Health Behaviors Study Section[LHB]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: NEW YORK

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: NARRATIVE The Center for Solutions for ME/CFS is dedicated to advancing the science of ME/CFS and advocating for the ME/CFS community through research that focuses on identifying genetic and environmental factors that contribute to disease and finding biomarkers that enable diagnosis and clinical management. In this second cycle of the Center, we will pursue complementary projects that examine samples collected in temporal proximity to variation in disease severity and prospectively, prior to diagnosis. We will test for antibody evidence of infections that may trigger initiation or exacerbation of symptoms; measure levels of small molecules in blood, saliva, and feces for clues to dysfunction at the cellular level, and sequence the genomes of people with ME/CFS to look for factors that influence risk for disease.

PI_NAMEs: LIPKIN, W. IAN  (contact)

PROGRAM_OFFICER_NAME: DALEY, WILLIAM PATRICK

PROJECT_TERMS: Acute;advocacy organizations;Advocate;antibody test;Biological;Biological Markers;Biology;Blood;Chronic Fatigue Syndrome;clinical diagnosis;Clinical Management;Communities;Complex;Dedications;Department of Defense;Diagnosis;Disease;disorder risk;Environmental Risk Factor;Event;Evolution;Exposure to;Feces;Functional disorder;gene environment interaction;Genetic;Genome;genome wide association study;Genotype;Immune system;Immunologics;Immunology;Individual;Infection;Infectious Agent;insight;Investments;Link;Measures;metabolomics;Methods;Molecular;Molecular Biology;pathogen;Pathogenesis;Peptides;Persons;Phage Display;Post-Acute Sequelae of SARS-CoV-2 Infection;prospective;repository;Research;Resources;Saliva;Sampling;Science;serosurveillance;Serum;Severities;Severity of illness;small molecule;smartphone application;statistics;Strategic Planning;Symptoms;Systemic infection;Technology;Variant;Viral

PROJECT_TITLE: Center for Solutions for ME/CFS

STUDY_SECTION_NAME: Special Emphasis Panel[ZNS1 SRB-E (04)]


NIH_SPENDING_CATS: Chronic Fatigue Syndrome (ME/CFS);Complementary and Integrative Health;Neurosciences

PROJECT_TERMS: Abbreviations;Academy;Air;Award;Biochemical;Biological;Biology;career development;Caring;Chronic Fatigue Syndrome;Clinical;Cohort Studies;Collaborations;Colorado;Communication;Communities;community collaboration;community partners;Computerized Medical Record;Data;Data Coordinating Center;data management;Department of Defense;Ensure;Environmental Exposure;Evolution;Foundations;Funding;genome wide association study;Genotype;International;meetings;member;Mentors;MicroRNAs;Molecular;pathogen;Patients;Persons;population based;Press Releases;programs;Progress Reports;prospective;Publications;repository;Research;Research Personnel;Research Project Grants;Resources;Sampling;Scientist;serosurveillance;Serum;Severities;smartphone application;Symptoms;Teleconferences;Training Activity;Training and Infrastructure;United Kingdom;United States National Institutes of Health;Universities;verbal;videoconference;Vision;Writing

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Chronic Fatigue Syndrome (ME/CFS);Clinical Research;Complementary and Integrative Health;Neurosciences

PHR: PROJECT NARRATIVE People with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) have “good days” and “bad days”. In this project people, with ME/CFS will report good and bad days using a smartphone application that will prompt a coordinator to make a site visit convenient for the patient and collect clinical information as well as biological samples for comprehensive analyses. Results will be used to identify factors associated with improvement or deterioration of health status that are anticipated to lead to new insights in strategies for intervention in ME/CFS.

PROJECT_TERMS: 5 year old;Abbreviations;Acids;Address;alpha ketoglutarate;Amendment;Antibodies;Antibody Response;associated symptom;authority;B-Lymphocytes;Biological;Biological Assay;Biological Markers;biomarker discovery;biomarker identification;Blood;Body mass index;carbohydrate metabolism;Carnitine;CD8B1 gene;Central Nervous System;Cerebrospinal Fluid;Chronic Fatigue Syndrome;Citric Acid Cycle;Clinical;clinical phenotype;Collaborations;Communication;Cross-Sectional Studies;cytokine;Data;Data Set;Dendritic Cells;Deterioration;Development;Diagnosis;Dinoprost;Disease;Energy Metabolism;Epitopes;Esters;Fatty Acids;fecal metabolome;Feces;Functional disorder;Generations;Health Insurance Portability and Accountability Act;Health Status;Hour;Hydroxylation;immune function;Immunity;Immunologics;Impairment;improved;Individual;Infection;Inflammatory;insight;Intervention;Laboratories;Lecithin;lipidomics;Liquid Chromatography;Location;Longitudinal Studies;Measurement;Medicine;metabolomics;microbial;microbial products;microbiome;MicroRNAs;mitochondrial dysfunction;Modeling;Molecular;Monitor;Multiomic Data;National Institute of Allergy and Infectious Disease;Natural Killer Cells;New York City;Pathogenesis;Pathway Analysis;Patients;Periodicity;Peripheral Blood Mononuclear Cell;Persons;Phage Display;Phospholipid Ethers;Physiological;Plasma;Plasmalogens;Post-Acute Sequelae of SARS-CoV-2 Infection;Prevalence;prevent;Proteome;Proteomics;Quality Control;Regulatory T-Lymphocyte;Reporting;Research;research and development;Research Personnel;Saliva;sample collection;Sampling;Severities;sex;single-cell RNA sequencing;Site Visit;smartphone application;Socioeconomic Status;stressor;Study Subject;Succinates;Surveys;Symptoms;System;T-Lymphocyte;Time;transcriptome;transcriptomics;Travel;Tricarboxylic Acids;United States National Institutes of Health;Update;Visit;Volatile Fatty Acids;Waxes

PROJECT_TITLE: Molecular Correlates of Symptom Severity in ME/CFS


NIH_SPENDING_CATS: Chronic Fatigue Syndrome (ME/CFS);Clinical Research;Complementary and Integrative Health;Genetics;Human Genome;Neurosciences

PHR: PROJECT NARRATIVE A hereditary component appears to exist for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). We propose a large genetic study to objectively examine the genes and biological pathways contributing to ME/CFS. This could allow us to determine a person's risk for the disease and open new avenues for therapeutics and treatment.

PI_NAMEs: PONTING, CHRIS P (contact)

PROJECT_TERMS: Abbreviations;Academy;Authorization documentation;biobank;Biological;Caring;case control;Chronic Fatigue Syndrome;cohort;Collection;Complex;Consensus;Data;data acquisition;data quality;design;Disease;disorder risk;Distant;DNA;DNA analysis;Epidemiology;evidence base;Evolution;General Population;Genes;Genetic;Genetic Anticipation;genetic association;Genetic study;genome sequencing;genome wide association study;Genotype;Health Professional;Immunity;improved;Individual;Infection;Inherited;insight;Institute of Medicine (U.S.);International;Intervention;Medicine;meetings;Meta-Analysis;Molecular;novel;Participant;Pathogenesis;Pathway interactions;Perception;Persons;Population;precision medicine;Predisposition;Procedures;Quality Control;Quantitative Trait Loci;Questionnaires;recruit;Research;Research Design;Risk;Saliva;Sampling;Single Nucleotide Polymorphism;smartphone application;Therapeutic;transcription factor;United Kingdom;whole genome

PROJECT_TITLE: Genotypic Analysis of ME/CFS


NIH_SPENDING_CATS: Chronic Fatigue Syndrome (ME/CFS);Clinical Research;Complementary and Integrative Health;Infectious Diseases;Neurosciences

PHR: NARRATIVE What causes people to develop ME/CFS is not known We will test the hypothesis that ME/CFS is triggered or exacerbated by infection. To do this, we will test samples for antibodies to viruses that were collected from people with ME/CFS before and after their diagnosis.

PI_NAMEs: MISHRA, NISCHAY  (contact)

PROJECT_TERMS: Abbreviations;Academy;acute flaccid myelitis;Address;Agonist;Air;Amino Acids;analog;Anti-viral Agents;Anti-viral Response;Antibodies;Antibody Response;Antigens;Army Personnel;B-Lymphocytes;Biological Assay;Blood;Body mass index;Cerebrospinal Fluid;chemokine;Chronic disability;Chronic Fatigue Syndrome;CLIA certified;Clinical;clinical database;Clinical Laboratory Improvement Amendments;Collection;cytokine;Cytomegalovirus;density;Department of Defense;Detection;Diagnosis;diagnostic assay;Dimensions;Disease;Double-Stranded RNA;Enterovirus;experience;fecal transplantation;Fever;gastrointestinal symptom;Herpesviridae;Human;Human Herpesvirus 4;Immune;Individual;Infection;Institute of Medicine (U.S.);Intravenous infusion procedures;Link;lymphadenopathy;Measures;Medicine;Methods;microbial;Modeling;Myalgia;Navy Personnel;Onset of illness;pathogen;Pathogenesis;Patients;Peptides;Performance;Personal Health Records;Persons;Phage Display;Plasma;prebiotics;Probiotics;Proteomics;Reporting;repository;Research;Resources;Respiratory Signs and Symptoms;response;Role;Sampling;SARS-CoV-2 infection;Serology;serosurveillance;Serum;Specimen;System;Testing;Tick-Borne Diseases;TLR3 gene;Uridine;Viral Antibodies;Virus;Virus Replication

PROJECT_TITLE: Pathogen Discovery Through Longitudinal Serological Surveillance in ME/CFS


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Infectious Diseases

ORG_DEPT: BIOLOGY

PHR: Narrative This research investigates the cell envelope of Gram-negative bacteria. Mathematical modeling and experiments are combined to elucidate the fundamental principles driving envelope composition and cell size across environmental conditions. As such, this research lays a mechanistic groundwork for the targeted development of novel treatment and prevention strategies against a major group of pathogenic bacteria.

PI_NAMEs: CREMER, JONAS B (contact)

PROGRAM_OFFICER_NAME: YU, GUOQIN

PROJECT_TERMS: Antibiotic Resistance;Automobile Driving;Bacteria;Bayesian Analysis;Behavior;Biochemical;Biological Assay;Biological Models;Cell Cycle;Cell division;cell envelope;Cell Physiology;Cell Size;Cell Wall;Cells;Characteristics;Couples;Coupling;density;Dependence;Development;Dimensions;DNA;dynamic system;env Gene Products;Environment;Escherichia coli;Experimental Models;experimental study;Foundations;Genetic Engineering;Geometry;global health;Gram-Negative Bacteria;Growth;Homeostasis;Individual;Investigation;Laws;Length;Link;Maintenance;Maps;mathematical model;Mathematics;Measures;Membrane;Membrane Proteins;Metabolic;Methods;Microscopy;Modeling;Molecular;Molecular Probes;novel;Nutrient;Organelles;pathogen;pathogenic bacteria;Pattern;Penicillin-Binding Proteins;periplasm;Periplasmic Proteins;Physiological;Physiological Processes;Population;Prevention strategy;Process;Proteins;Proteome;Rationalization;Regulation;Replication Initiation;Research;Resource Allocation;Respiration;rho;Ribosomes;Rod;Role;Shapes;System;theories;treatment strategy;uptake;Variant;Waste Products;Width

PROJECT_TITLE: Mechanisms of cell-size control in Gram-negative bacteria

STUDY_SECTION: MABS

STUDY_SECTION_NAME: Modeling and Analysis of Biological Systems Study Section[MABS]


NIH_SPENDING_CATS: Cancer;Hematology;Radiation Oncology

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: NARRATIVE This project is a continuation of a highly successful Oncology-specific K12 program at the University of North Carolina at Chapel Hill that aims to train a cadre of highly successful and productive clinical researchers that will become leaders in their respective fields in years to come.

PI_NAMEs: KIM, WILLIAM Y. (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: Admission activity;Adult;Advocate;Area;Award;Clinical Trials;cohort;Communication;Development;Evaluation;experience;Faculty;Funding;Genetic;Goals;Grant;Health Services Research;Hematology;Malignant Neoplasms;medical schools;Medicine;member;Mentored Clinical Scientist Development Program;Mentors;mid-career faculty;North Carolina;Oncology;Outcomes Research;Pathology;patient oriented;patient oriented research;Patients;Pediatric Hematology;Pharmacology;professor;programs;Progress Reports;Publications;Radiation Oncology;Records;recruit;Research;Research Personnel;Research Project Grants;Scientist;skill acquisition;success;Surgeon;Surgical Oncology;Teacher Professional Development;Time;Training;Training Programs;Translational Research;Universities;Urology

PROJECT_TITLE: UNC Oncology K12

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 RTRB-R (J1)]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_CITY: LA JOLLA

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

PHR: Project Narrative: Influenza virus infection involves interaction with sialic acid-containing glycans in the respiratory tract. We will develop efficient methods for assembling a new glycan array of multi-antennary glycans commonly found on the respiratory tract to detect influenza variants. Using glycoengineering, we will also develop homogeneous antibodies and conjugates against influenza variants with improved efficacy.

PI_NAMEs: WONG, CHI-HUEY  (contact)

PROGRAM_OFFICER_NAME: BASU, DIPANWITA

PROJECT_TERMS: Address;airway epithelium;anti-influenza;Anti-viral Agents;Antibodies;Antibody Specificity;Antigens;antiviral drug development;Asian;Binding;Biological;Carbohydrates;Cell-Mediated Cytolysis;Cells;combat;Complex;Detection;detection method;Development;Diagnostic Procedure;diagnostic tool;Disease;Drug resistance;effective therapy;Engineering;Epithelial Cells;Evaluation;Exhibits;Fc Receptor;fighting;flu;Fucose;Fucosyltransferase;Funding;Glycoconjugates;Glycoengineering;Glycoproteins;glycosylation;Half-Life;Hemagglutinin;Hong Kong;Immune;Immune response;Immunization;improved;In Vitro;in vivo;Infection;Influenza;Influenza A virus;influenza infection;influenza outbreak;influenza virus strain;influenza virus vaccine;influenzavirus;Knowledge;Life;link protein;Measures;Mediating;Membrane Proteins;Methods;Modification;Monoclonal Antibodies;Neuraminidase;Neuraminidase inhibitor;neutralizing antibody;novel diagnostics;Oligosaccharides;Oseltamivir;pandemic disease;pandemic potential;Pathologic;Polysaccharides;Prevention;programs;prophylactic;Protein Biosynthesis;Proteins;Public Health;rapid detection;receptor;recruit;Research;Respiratory System;Sampling;sialic acid receptor;Sialic Acids;sialylation;Spanish flu;Specificity;Structure;sugar;Surface;swine flu;tool;universal vaccine;Vaccines;Variant;Viral;Viral Hemagglutinins;Virus;Virus Diseases;Virus Receptors;zanamivir

PROJECT_TITLE: Targeting Influenza A Virus by a Carbohydrate-inspired Strategy

STUDY_SECTION: CSB

STUDY_SECTION_NAME: Chemical Synthesis and Biosynthesis Study Section[CSB]


NIH_SPENDING_CATS: Lung;Neurosciences;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Rehabilitation;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_CITY: LEXINGTON

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: Project Narrative Public Relevance: Nearly 300,000 individuals in the United States have a spinal cord injury and close to 60% are at the cervical level. As a result, respiratory motor insufficiency is a major concern and necessitates the need for a mechanical ventilator in order to breathe and survive. This grant application explores a novel combinatorial approach to restore breathing, by promoting axon growth of respiratory pathways and applying respiratory training.

PI_NAMEs: ALILAIN, WARREN JOSEPH;CHEN, MEIFAN  (contact)

PROGRAM_OFFICER_NAME: BAMBRICK, LINDA LOUISE

PROJECT_TERMS: Acute;Adult;Anatomy;Animal Model;Applications Grants;Astrocytes;Axon;axon growth;axonal sprouting;Breathing;Cell Nucleus;central nervous system injury;Cerebral cortex;Cervical;Cervical spinal cord injury;Ciliary Neurotrophic Factor;combinatorial;Corticospinal Tracts;Coupled;Coupling;cytokine;Development;Forelimb;Frequencies;functional plasticity;Glial Fibrillary Acidic Protein;Growth;Human;Hypoxia;Impairment;improved;in vivo;Individual;Injury;Intervention;ischemic injury;Lateral;Leucine Zippers;Location;Maintenance;Measures;Mechanical Ventilators;Mediating;Modeling;Molecular;Motor;motor recovery;Mus;nerve supply;neural network;Neural Pathways;Neuronal Plasticity;Neurons;normoxia;novel;overexpression;Pathway interactions;PF4 Gene;Phosphotransferases;programs;Recovery;Recovery of Function;regenerative;Rehabilitation therapy;Reporting;respiratory;Respiratory System;restoration;Role;Serotonin;Shapes;Spinal Cord;Spinal cord injured survivor;Spinal cord injury;Spinal Injections;Synaptic plasticity;synergism;Tamoxifen;Testing;Therapeutic;Tidal Volume;Training;translational approach;trend;United States;Up-Regulation;ventilation

PROJECT_TITLE: Combinatorial approach to restore breathing after spinal cord injury

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_CITY: ROCHESTER

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: Project Narrative The proposed research will investigate the role of vCA1 feedback on neural representations of environment and odors in the main olfactory bulb, a circuit critical to sensory perception and memory. Mice are one of the major model organisms for studying olfaction, and many circuits principles are conserved across evolution, making them critical to understanding neurodegenerative and neurological disorders like Alzheimer’s Disease, Parkinson’s and COVID. This proposal will improve our understanding of the functional coupling between brain regions involved in sensory perception and those involved in learning, emotion, and memory.

PI_NAMEs: PADMANABHAN, KRISHNAN  (contact)

PROGRAM_OFFICER_NAME: SABRI, MERAV

PROJECT_TERMS: 3D Print;Affect;Alzheimer's Disease;Animal Model;Animals;Anterior;Anxiety;Area;Behavior;behavior measurement;Behavioral;biophysical properties;Biophysics;Brain;Brain region;cell type;Cells;Chemicals;Code;Cognition;Cognition Disorders;Cognitive;Complex;Computing Methodologies;Coupling;COVID-19;density;Disease;Electrophysiology (science);Emotions;entorhinal cortex;Environment;Evaluation;Evolution;experimental study;Feedback;granule cell;hippocampal pyramidal neuron;Hippocampus;Human;improved;Individual;innovation;insight;Interneurons;Label;Learning;lens;Limbic System;Link;Location;Machine Learning;Mammals;Memory;Methods;mitral cell;model organism;Modeling;Mus;Nervous System Disorder;neural;neural circuit;Neurodegenerative Disorders;Neurons;neuropsychiatric disorder;novel;Odors;Olfaction Disorders;olfactory bulb;Olfactory Cortex;olfactory nuclei;Olfactory Pathways;Parkinson Disease;patch clamp;Pattern;Perception;Physics;Physiology;piriform cortex;Population;Property;Pyramidal Cells;Research;Rodent;Role;Route;Sensory;Shapes;Signal Transduction;Smell Perception;Structure;Study models;Synapses;System;Testing;transmission process;Viral;Volatilization;Work

PROJECT_TITLE: Effect of hippocampal feedback projections on the function of the early olfactory system

STUDY_SECTION: NIC

STUDY_SECTION_NAME: Neuroscience of Interoception and Chemosensation Study Section[NIC]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Cancer;Clinical Research;Comparative Effectiveness Research;Patient Safety

ORG_CITY: BALTIMORE

ORG_DEPT: ORTHOPEDICS

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: ▪ PROJECT NARRATIVE ▪ Metastatic bone disease of the proximal femur has traditionally been treated with internal fixation; however, preliminary data suggests treating these lesions with resection and endoprosthetic reconstruction may yield better outcomes. While promising, data supporting the use of resection and endoprosthetic reconstruction is limited, and clinical practice would benefit from a definitive trial that clearly defines the optimal surgical treatment for patients with metastatic bone disease of the proximal femur. We propose a two-year planning period for the Proximal FEmur Resection or Internal Fixation fOR Metastases (PERFORM) randomized controlled trial during which we will finalize the trial protocol, establish the trial infrastructure, and prepare the participating clinical sites for initiation.

PI_NAMEs: GHERT, MICHELLE ;O'HARA, NATHAN NOEL (contact);SPRAGUE, SHEILA

PROGRAM_OFFICER_NAME: WASHABAUGH, CHARLES H

PROJECT_TERMS: Address;Affect;Authorization documentation;bone;Bone Diseases;Carcinoma;Clinical;clinical practice;clinical research site;clinical trial protocol;Clinical Trials;clinically relevant;Consensus;Contracts;Data;Data Management Resources;design;disorder risk;electronic data;Ensure;Equipoise;Excision;experience;Failure;Femur;Funding;Grant;Implant;improved;Infrastructure;Institutional Review Boards;Lesion;Life;Location;Metastatic Carcinoma;Methodology;Morbidity - disease rate;Multicenter Trials;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;Neoplasm Metastasis;Oncology;Operative Surgical Procedures;Orthopedic Surgery;Orthopedics;Outcome;Pain;patient mobility;Patient Outcomes Assessments;patient population;Patient-Focused Outcomes;Patients;Phase;Procedures;Process;prospective;Protocols documentation;Quality of life;Randomized;Randomized, Controlled Trials;reconstruction;Research;Risk Reduction;sample fixation;Second Look Surgery;Selection Criteria;Site;skeletal disorder;Skeleton;Source;Surgical Management;surgical risk;Testing;Time;Training;trial comparing;trial design;trial planning;Work

PROJECT_TITLE: A Planning Grant for a Multi-Center Randomized Controlled Trial Comparing Resection and Endoprosthetic Reconstruction vs. Internal Fixation for Metastatic Bone Disease of the Proximal Femur

STUDY_SECTION: AMSC

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Clinical Trials Study Section [AMSC]


NIH_SPENDING_CATS: Cardiovascular;Genetics;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: HOUSTON

ORG_NAME: METHODIST HOSPITAL RESEARCH INSTITUTE

PHR: Our laboratory has identified a role for glycolysis in transflammation and studies proposed here will characterize the dependency of acetyl-CoA metabolism on innate immune activation and identify the epigenetic effects of acetyl-CoA during transdifferentiation in vivo. Further, we will confirm the role of glycolysis in transdifferentiation using an established mouse model of peripheral artery disease. Completion of these studies will provide a novel pathway utilized by cells undergoing fate determination.

PI_NAMEs: LAI, LI  (contact)

PROGRAM_OFFICER_NAME: KINDZELSKI, ANDREI L

PROJECT_TERMS: Acetyl Coenzyme A;Address;Affect;ATP Citrate (pro-S)-Lyase;Blood flow;blood perfusion;Blood Vessels;Carbon;Cardiovascular Diseases;Cardiovascular system;Cell Fate Control;Cell Lineage;Cell Nucleus;cell type;Cells;Cellular Metabolic Process;Characteristics;citrate carrier;Citrates;Couples;Data;density;Dependence;differentiation in vitro;DNA;Endothelial Cells;Endothelium;Enhancers;Enzymes;Epigenetic Process;epigenetic regulation;experimental study;Fibroblasts;fluidity;Foundations;gain of function;Genes;Global Change;Glycolysis;healing;Hindlimb;Histone Acetylation;immune activation;Immune signaling;In Vitro;in vivo;in vivo regeneration;induced pluripotent stem cell;Inflammatory;inhibitor;Innate Immune Response;IRF3 gene;Ischemia;Isolated limb perfusion;Knock-out;Label;Laboratories;limb ischemia;loss of function;Measurement;Mediating;Metabolic;Metabolic Pathway;Metabolism;metabolomics;Mitochondria;Molecular;mouse model;multiple omics;Mus;Natural regeneration;novel;novel strategies;novel therapeutics;nuclear reprogramming;Nutrient;Pathway interactions;Pattern;Pattern recognition receptor;Perfusion;Peripheral arterial disease;pharmacologic;Phenotype;Play;pluripotency;Process;Production;Recovery;Regenerative Medicine;Regulation;repaired;response;restoration;revascularization;RNA;Role;Signal Transduction;single-cell RNA sequencing;small molecule;Somatic Cell;Sorting;Source;Testing;Time;tissue regeneration;tissue repair;Tissues;Toll-like receptors;tool;transdifferentiation;Vascular regeneration;Work

PROJECT_TITLE: Metabolism and Epigenetic Regulation are Couples in Transdifferentiation and Vascular Regeneration

STUDY_SECTION: BBHV

STUDY_SECTION_NAME: Basic Biology of Blood, Heart and Vasculature Study Section [BBHV]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Immunotherapy;Women's Health Research

ORG_CITY: SAINT LOUIS

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: NARRATIVE Nontumor cells aid tumor cell growth and help tumor cells evade the immune system. We find that by inhibiting a protein called p38MAPK in these non-tumor cells, we can reduce metastatic tumor growth. Because there are many different types of nontumor cells in a growing metastatic tumor and we do not know which ones assist incipient tumor cell growth and survival, the goal of this work is to identify the cells, learn how they help tumor cells grow and use that information to design more potent anti-tumor therapies.

PI_NAMEs: STEWART, SHEILA A (contact)

PROGRAM_OFFICER_NAME: BERA, TAPAN K

PROJECT_TERMS: Adipocytes;Agonist;angiogenesis;anti-tumor immune response;Antigens;antitumor effect;Automobile Driving;bone;bone loss;bone turnover;breast cancer diagnosis;breast cancer metastasis;Breast Cancer Model;Breast Cancer Patient;breast cancer progression;carcinogenesis;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CDKN2A gene;cell growth;Cell Survival;cell type;Cells;Cessation of life;Chondrocytes;Clinical Trials;clinically relevant;Combination immunotherapy;combinatorial;cytokine;Databases;Dendritic Cells;design;Disease;Endothelial Cells;Environment;Fibroblasts;Genetic;genetic signature;Goals;Immune;Immune Evasion;Immune response;Immune system;immunoregulation;Immunotherapy;Interferons;Knowledge;Learning;Localized Disease;Macrophage;Malignant Neoplasms;MAP Kinase Gene;Memory;Metastatic breast cancer;Metastatic Neoplasm to the Bone;Mitogen-Activated Protein Kinase Inhibitor;Modeling;Mus;neglect;Neoplasm Metastasis;neoplastic cell;Neurons;novel;novel strategies;Osteoblasts;Osteoclasts;Osteocytes;OX40;p38 Mitogen Activated Protein Kinase;Pain;palliative;Pathological fracture;Patients;Pharmaceutical Preparations;pharmacologic;Play;Pre-Clinical Model;predict clinical outcome;Primary Neoplasm;Proteins;Resistance;Role;senescence;senescence associated secretory phenotype;senescent cell;senolytics;Signal Transduction;Site;Stromal Cells;Supporting Cell;synergism;Therapeutic;tool;Toxic effect;trafficking;TRANCE protein;tumor;tumor growth;tumor progression;Work

PROJECT_TITLE: Leveraging the metastatic tumor stroma to limit breast cancer progression

STUDY_SECTION: THI

STUDY_SECTION_NAME: Tumor Host Interactions Study Section[THI]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Contraception/Reproduction;Emerging Infectious Diseases;Infectious Diseases;Rare Diseases;Sexually Transmitted Infections;Vector-Borne Diseases;Zika Virus

ORG_CITY: BLACKSBURG

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

ORG_STATE: VA

PHR: Project Narrative The proposed research is relevant to public health because it will investigate the sexual transmission of Zika virus (ZIKV), which causes severe birth defects in infants born to mothers infected by ZIKV during pregnancy. By identifying the mechanisms of ZIKV shedding in semen, this work will lead to the development of tools to prevent ZIKV sexual transmission.

PI_NAMEs: DUGGAL, NISHA  (contact)

PROGRAM_OFFICER_NAME: GAUTAM, RAJEEV

PROJECT_TERMS: Acute;acute infection;Africa;African;Americas;Asian;Bite;Blood;cell type;Cells;Chimera organism;chronic infection;cohort;Congenital Abnormality;Culicidae;Disease;Ejaculation;emerging virus;Epidemic;Epididymis;Epithelial Cells;Epithelium;Flavivirus;Future;Genes;Genotype;Geography;Goals;Haiti;Human;human disease;Immune;Immunohistochemistry;in vivo Model;Infant;Infection;Infiltration;Inflammation;innovation;Kinetics;Macrophage;male;Maternal-Fetal Transmission;Measures;men;Microcephaly;Modeling;mosquito-borne;Mothers;mouse model;Mus;novel;Onset of illness;Pregnancy;prenatal exposure;prevent;Public Health;reproductive tract;Research;reverse genetics;Role;Sampling;Seminal fluid;Sexual Transmission;Sexual transmission of Zika;sexually transmitted virus;Structural Genes;structural viral genes;Symptoms;Syndrome;System;Testis;time use;tool development;transmission process;Viral;viral RNA;Virus;virus genetics;virus host interaction;Virus Shedding;virus tropism;Woman;Work;Zika Virus;ZIKV infection

PROJECT_TITLE: Determinants of acute and persistent Zika virus shedding in semen

STUDY_SECTION: VDT

STUDY_SECTION_NAME: Viral Dynamics and Transmission Study Section [VDT]


NIH_SPENDING_CATS: Genetics

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative Many human diseases result in the accumulation of aggregated proteins within the ER impairing its function therefore, it is important to understand how these damaged regions of the ER are cleared by autophagy (ER- phagy). We have proposed a model in which actin assembly at ER-endosome contacts in yeast displaces the cortical ER from the plasma membrane to promote its interaction with the autophagosome assembly machinery. We will conduct a genetic test of this model, order intermediates on the ER-phagy pathway and explore the relevance of our findings to mammalian ER-phagy.

PI_NAMEs: NOVICK, PETER JAY (contact)

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TERMS: Actins;Adaptor Signaling Protein;Affect;Autophagocytosis;Autophagosome;Biological Assay;Bypass;Cell membrane;Cells;Coated vesicle;Complement;Complex;COPII-Coated Vesicles;coronin protein;Cytoplasmic Tail;Data;Defect;Diabetes Mellitus;Elements;Endocytosis;Endoplasmic Reticulum;Endosomes;Event;Fluorescence;Genes;Genetic;genetic testing;Goals;human disease;Impairment;inhibitor;knock-down;Link;Lysosomes;Mammalian Cell;Mass Spectrum Analysis;Microscopy;misfolded protein;Modeling;moesin;Molecular;mutant;Mutation;Myosin ATPase;Neurodegenerative Disorders;novel;Pathway interactions;Physical condensation;Play;polymerization;Polymers;Process;protein aggregation;Proteins;receptor;recruit;response;Role;scaffold;Site;Small Interfering RNA;Starvation;Testing;Vacuole;Visualization;Yeasts

PROJECT_TITLE: Genetics of secretion in yeast

STUDY_SECTION_NAME: Cell Structure and Function 1 Study Section[CSF1]


NIH_SPENDING_CATS: Bioengineering;Brain Disorders;Cardiovascular;Congenital Heart Disease;Congenital Structural Anomalies;Data Science;Down Syndrome;Genetics;Heart Disease;Intellectual and Developmental Disabilities (IDD);Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pediatric;Rare Diseases

ORG_CITY: PROVO

ORG_NAME: BRIGHAM YOUNG UNIVERSITY

ORG_STATE: UT

PHR: PROJECT NARRATIVE For the past two decades, researchers have generated molecular proﬁles of Down syndrome individuals and controls and have posted these proﬁles in public repositories so that others can reuse them. However, reuse is difﬁcult because researchers must be familiar with how to process each type of data, and they must deal with inconsistencies in terminologies used to describe research subjects. We will undergo a curation effort to address these problems on behalf of the Down syndrome research community and develop novel computational methodologies for combining such datasets in a way that addresses systematic differences between datasets.

PI_NAMEs: PICCOLO, STEPHEN  (contact)

PROGRAM_OFFICER_NAME: LI, HUIQING

PROJECT_TERMS: Acceleration;Acute Myelocytic Leukemia;Address;Age;Algorithms;Artificial Intelligence;Autoimmune Diseases;Bioinformatics;biomedical ontology;cell type;Classification;cohort;Collaborations;Common Data Element;Communities;comparison group;Complement;computerized data processing;Computers;Computing Methodologies;congenital heart abnormality;Congenital Heart Defects;Data;Data Coordinating Center;data curation;data hub;data integration;data modeling;data quality;data resource;data reuse;Data Set;data sharing;Databases;deep neural network;Dementia;design;Diagnosis;Diagnostic;Disease;disorder subtype;Disparate;DNA Methylation;Down's Syndrome;Edward's syndrome;empowerment;Environmental Risk Factor;FAIR principles;Funding Agency;Gene Expression;Generations;generative adversarial network;Genes;Health;Human;human data;improved;Individual;Influentials;insight;interoperability;Investments;Laboratories;Lead;leukemia;Machine Learning;Maps;Medical;Metadata;Modeling;Molecular;Molecular Abnormality;Molecular Profiling;mouse model;Mouse Strains;mRNA Expression;multiple datasets;Mus;novel;Ontology;Outcome;Patau's syndrome;Pattern;Performance;Persons;Phenotype;Population;Prediction of Response to Therapy;Process;Public Domains;public repository;Publishing;reference genome;Reproducibility;Research;Research Design;Research Personnel;Research Subjects;Resource Sharing;Resources;Rewards;Sample Size;Sampling;Semantics;sex;Site;software development;Source;Standardization;Structure;Techniques;Technology;Terminology;Time;Treatment outcome;United States National Institutes of Health;Visualization;Work;Writing

PROJECT_TITLE: Curation and analysis of publicly available, molecular profiles from people with Down Syndrome

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IVBH-B (56)]


NIH_SPENDING_CATS: Neurosciences

ORG_CITY: BOSTON

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: Narrative Pathological alterations in neuronal signal transmission are a hallmark of many neurological disorders, including neurodegeneration, autism, and schizophrenia. In the present project, we dissect molecular mechanisms that underlie the release of chemical signals from neurons. Our results will provide detailed insight into neuronal communication, which forms a foundation for studying how such communication fails in brain disorders.

PI_NAMEs: KAESER, PASCAL SIMON (contact)

PROGRAM_OFFICER_NAME: MATOS GALICIA, HEIDI YANICE

PROJECT_TERMS: Ablation;Acetylcholine;Acute;autism spectrum disorder;Axon;Binding;Binding Sites;Brain;Brain Diseases;C-terminal;Cell membrane;Cells;chemical release;Communication;Data;Dependence;Disease;Dissection;Distal;Docking;Dopamine;EF Hand Motifs;Electrophysiology (science);Elements;Exocytosis;experimental study;extracellular;Family;Foundations;Funding;Genetic;Goals;Hippocampus;Hybrids;Image;Impairment;insight;interest;Knock-out;knockout gene;Knowledge;live cell imaging;Mediating;Microscopic;millisecond;Modeling;Molecular;mouse genetics;Mutate;Mutation;Nerve;Nerve Degeneration;Nervous System Disorder;Neuromodulator;Neurons;neuroregulation;neurotransmission;neurotransmitter release;Neurotransmitters;Norepinephrine;Pathologic;Pharmacology;Positioning Attribute;postsynaptic;presynaptic;prevent;Property;Proteins;recruit;Role;scaffold;Scaffolding Protein;Schizophrenia;sensor;Serotonin;Site;Slice;Structure;superresolution microscopy;Synapses;Synaptic Receptors;Synaptic Transmission;System;Testing;transmission process;ultra high resolution;Vesicle;vesicular release;voltage;Work

PROJECT_TITLE: Molecular Dissection of Active Zone Functions in Neurotransmitter Release

STUDY_SECTION: NC

STUDY_SECTION_NAME: Neuronal Communications Study Section[NC]