NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: PLAINSBORO

ORG_NAME: ATUX ISKAY GROUP LLC

PHR: There is a considerable body of evidence that protein phosphatase 2A (PP2A) activity is reduced in Alzheimer’s Disease and other neurodegenerative conditions and this underlies multiple factors contributing to pathology. This SBIR Phase 2 proposal is directed at initial pre-clinical steps in development of a lead compound, ATUX-5800, as a novel, disease modifying, Alzheimer’s Disease therapeutic. The lead compounds and back-ups are compact, drug-like, structures that directly target PP2A holoenzymes in the brain, thus simultaneously addressing multiple drivers of AD pathology.

PI_NAMEs: OHLMEYER, MICHAEL  (contact)

PROJECT_TERMS: Address;Age Years;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease related dementia;Alzheimer's disease therapeutic;amyloid precursor protein processing;Animal Model;Behavioral;Binding;Biological Availability;Brain;Budgets;Canis familiaris;care costs;Cell model;Chemistry;Cognitive deficits;commercialization;cost;cost estimate;cost of dementia;Data;design;Development;Dihydropyridines;Disease;disease model;Disease Progression;Dose;drug discovery;Economics;efficacy study;Electrophysiology (science);enantiomer;Family;Holoenzymes;Human;human old age (65+);improved;In Vitro;in vivo;Isomerism;Laboratories;Lead;Life;Long-Term Potentiation;medication safety;member;Modeling;Modification;Molecular;mouse model;Nerve Degeneration;Neurodegenerative Disorders;neuroinflammation;neuroprotection;novel;novel therapeutics;Oral;Pathogenesis;Pathologic;Pathology;Patients;Penetration;Pharmaceutical Chemistry;Pharmaceutical Preparations;Phase;Phenotype;Phosphoric Monoester Hydrolases;Positioning Attribute;pre-clinical;preclinical development;prevent;Process;Program Development;programs;Protein phosphatase;protein structure;prototype;Publishing;Pyrans;Rationalization;Rattus;Reporting;Research;Resolution;Risk;risk mitigation;Route;Running;Safety;safety assessment;safety study;scale up;Series;Small Business Innovation Research Grant;structural biology;Structure;Sulfonamides;Symptoms;Synapses;Synaptic plasticity;tau Proteins;tau-1;Toxicology;Transgenic Mice;Urea;Work

PROJECT_TITLE: Direct protein phosphatase 2A (PP2A) activators as novel Alzheimer’s Disease (AD) therapeutics

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 AN-P (90)]


ADMINISTERING_IC: AG

ARRA_FUNDED: N

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Brain Disorders;Complementary and Integrative Health;Dementia;Dietary Supplements;Nanotechnology;Natural Products;Neurodegenerative;Neurosciences

ORG_CITY: PROSPECT

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: 3P BIOTECHNOLOGIES, INC.

ORG_STATE: KY

PHR: Narrative (Public Health Relevance Statement)  In the proposed project, we will use a novel nano formulation of curcuminoids to mitigate neuroinflammation and attenuate neurological diseases with emphasis on Alzheimer’s disease (AD). In our approach, curcuminoids, known for their potent anti-inflammatory activity and activities inhibiting early brain markers of AD including neurofibrillary tangles and amyloid plaque formation, will be sequestered in exosomes (natural nanoparticles), isolated from standardized bovine colostrum powder, to increase bioavailability. The exosomes will be decorated with folic acid whose receptors are expressed in high levels in the brain, to target the brain sub tissues such as cortex and hippocampus, and the formulation is delivered by a novel trans-spinal (t.s.) topical route for efficient brain delivery and the efficacy assessed using transgenic mouse model of AD.

PI_NAMEs: GUPTA, RAMESH C (contact)

PROGRAM_OFFICER_NAME: MARTIN, ZANE

PROJECT_TERMS: 3xTg-AD mouse;abeta accumulation;AD transgenic mice;Affect;Age;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease therapeutic;Alzheimer’s disease biomarker;Amyloid beta-Protein Precursor;Animal Model;Anti-Inflammatory Agents;Area;Attenuated;behavior test;beta-site APP cleaving enzyme 1;Biodistribution;Biological Availability;Biological Markers;blood-brain barrier crossing;Brain;Brain region;brain tissue;Brain-Derived Neurotrophic Factor;Cattle;Clinical;Clinical Research;Cognitive;cognitive function;Colostrum;Curcumin;cyanine;Data;demethoxycurcumin;Development;Disease;Disease Progression;donepezil;Dose;Drug Delivery Systems;drug standard;Dryness;Effectiveness;efficacy evaluation;Electrophoretic Mobility Shift Assay;exosome;experience;FDA approved;folate-binding protein;Folic Acid;Formulation;Gene Expression;Goals;Hepatic;Hippocampus;Human;Immunoassay;immunotoxicity;In Vitro;Inflammation;Inflammation Mediators;Inflammatory Response;Intervention Studies;Label;Lead;Mediating;Metabolism;Microglia;Minor;Molecular Target;Mus;nanoformulation;nanoparticle;Nervous System Disorder;Neuroblastoma;neuroblastoma cell;Neurodegenerative Disorders;Neurofibrillary Tangles;neuroinflammation;neuroprotection;novel;Oral;Persons;Pharmaceutical Preparations;Phase;Plants;Powder dose form;preclinical study;Progress Reports;Property;protein expression;public health relevance;receptor;reduce symptoms;Reporting;Research;Research Personnel;Rodent;Route;Senile Plaques;SIRT1 gene;small molecule;Spinal;Standardization;System;targeted delivery;tau-1;Testing;Therapeutic;Tissues;Toxic effect;Transgenic Mice;treatment response

PROJECT_TITLE: Trans Spinal Delivery of a Targeted Nanoformulation of Curcuminoids to Treat AD

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 AN-P (11)]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Harm Reduction for Substance Misuse;Health Services;Prevention;Rehabilitation;Social Determinants of Health;Substance Misuse

ORG_CITY: SPOKANE

ORG_NAME: HART3S - A SOCIAL PURPOSE CORPORATION

ORG_STATE: WA

PHR: PUBLIC HEALTH RELEVANCE STATEMENT Because the vast majority of people (93%) who experience alcohol use disorder do not attend in-person, abstinence-based treatment, mobile harm reduction treatment for alcohol use disorder (mHaRT-A) – which does not require abstinence or in-person treatment attendance – is well-positioned to vastly improve intervention access. This project’s aims are to develop and initially test an accessible, low-barrier mHealth application to reduce alcohol-related harm and improve quality of life for individuals in this high-morbidity and high-cost population. In the longer term, mHaRT-A has the potential to make a public health impact through its broader dissemination, both directly to consumers as a standalone product and to larger healthcare systems for use as an adjunct to clinical care.

PI_NAMEs: COLLINS, SUSAN E (contact)

PROGRAM_OFFICER_NAME: WHITAKER, DAMIYA EVE

PROJECT_TERMS: Abstinence;acceptability and feasibility;Address;alcohol abstinence;alcohol abuse therapy;alcohol availability;Alcohol consumption;alcohol intervention;alcohol use disorder;alcohol-related death;Alcohols;barrier to care;biopsychosocial;care systems;Cessation of life;clinical care;commercialization;cost;COVID-19 pandemic;Data;design;Development;digital technology;Disease remission;drinking;Drug Controls;Drug usage;evidence base;experience;feasibility testing;Feedback;field study;Financial cost;flexibility;Foundations;Funding;General Population;Goals;Harm Reduction;Health;Health Personnel;health related quality of life;Health Services;Health Technology;Healthcare Systems;Heavy Drinking;help-seeking behavior;Human;human centered design;improved;Individual;innovation;Intervention;Interview;Laboratories;marginalization;Marketing;Meta-Analysis;Methods;mHealth;mobile app development;mobile application;Morbidity - disease rate;National Institute on Alcohol Abuse and Alcoholism;pandemic disease;Participant;patient oriented;Patients;Persons;Phase;Population;Positioning Attribute;preference;Procedures;prototype;Public Health;public health relevance;Quality of life;randomized, clinical trials;Recovery;recruit;reduced alcohol use;Reporting;Research;Research Design;Research Personnel;response;Service provision;Small Business Technology Transfer Research;social;social stigma;Stigmatization;substance use treatment;Surveys;Symptoms;System;Testing;Time;treatment services;United States National Institutes of Health;usability;web app

PROJECT_TITLE: Development of a mobile harm reduction treatment for alcohol use disorder (mHaRT-A)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CCHI-J (10)]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Immunization;Immunotherapy;Orphan Drug;Ovarian Cancer;Rare Diseases;Women's Health Research

ORG_CITY: MURRIETA

ORG_NAME: TRIO PHARMACEUTICALS INC.

ORG_STATE: CA

PHR: PROJECT NARRATIVE Ovarian cancer is the fifth leading cause of cancer deaths for women with a 5-year survival rate of 50%. Current treatment strategies are largely ineffective as there is a high rate of recurrence, thus alternate treatments that are safe and effective are direly needed. Trio Pharmaceuticals (TRIO) is developing a novel antibody drug (TRIO- 628) designed to specifically eliminate cancer cells and myeloid derived suppressor cells, while leaving normal cells unharmed.

PI_NAMEs: LAUS, REINER  (contact)

PROGRAM_OFFICER_NAME: BOZZA, WILLIAM PATRICK

PROJECT_TERMS: Adjuvant Therapy;Affinity;Antibodies;Antineoplastic Agents;Apoptosis;Binding;cancer cell;Cancer Etiology;Cancer Patient;CD34 gene;CD8B1 gene;Cell Line;Cells;chemotherapy;Circulation;Clinical;Clinical Trials;clinically relevant;Coculture Techniques;cohort;Data;design;Drug Combinations;effective therapy;Effector Cell;effector T cell;efficacy evaluation;efficacy study;Engraftment;experience;FOLR1 gene;Goals;Human;humanized mouse;Immune;Immune checkpoint inhibitor;Immune system;Immunity;immunogenic;Immunooncology;Immunosuppression;Immunosuppressive Agents;improved;In Vitro;in vivo;in vivo Model;innovation;Laboratories;Malignant neoplasm of ovary;Malignant Neoplasms;Measures;Mediating;monocyte;mouse model;Myeloid Cells;Myeloid-derived suppressor cells;Neoadjuvant Therapy;Normal Cell;novel;Operative Surgical Procedures;overexpression;Pathway interactions;patient derived xenograft model;Patients;PD-1 inhibitors;Peripheral Blood Mononuclear Cell;Pharmaceutical Preparations;Pharmacologic Substance;Phase;Platinum;Prior Therapy;programs;Recurrence;Resistance;restoration;Safety;side effect;Small Business Innovation Research Grant;standard of care;Survival Rate;T-Cell Proliferation;T-Lymphocyte;taxane;Testing;Therapeutic antibodies;TNFRSF10B gene;Toxic effect;Toxin Conjugates;translational study;Transplantation;Treatment Efficacy;Treatment outcome;treatment strategy;tumor;Tumor Antigens;Tumor Burden;Tumor Immunity;tumor-immune system interactions;Women's mortality;Women's prevalence;Xenograft procedure

PROJECT_TITLE: A novel targeted antibody therapeutic to treat ovarian cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CDPT-R (12)]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Hematology;Orphan Drug;Precision Medicine;Rare Diseases;Sickle Cell Disease

ORG_CITY: Detroit

ORG_NAME: FUNCTIONAL FLUIDICS, LLC

ORG_STATE: MI

PHR: PROJECT NARRATIVE RBC propensity to sickle under hypoxia is a critical feature of SCD; however, there are no easy-to-use methods available to clinicians or pharmacology researchers to assess it. Functional Fluidics is providing the first rapid and convenient assay, to be translated into a small footprint, stand-alone system, to assess hypoxia induced RBC sickling. Our long-term goal is a diagnostic device for assessing sickle patient conditions and predicting treatment efficacy at point-of-care.

PI_NAMEs: HINES, PATRICK  (contact)

PROGRAM_OFFICER_NAME: AGRAWAL, NITIN

PROJECT_TERMS: Address;Adhesions;Adverse event;Affect;Affinity;Algorithms;Artificial Intelligence;assay development;Assessment tool;Automation;Biochemical Reaction;Biological Assay;biomarker validation;Blood;Blood specimen;Caring;Cellular Morphology;Clinic;Clinical;Clinical Management;Clinical Trials;commercial application;companion diagnostics;cost;Data;Data Analyses;Detection;Developing Countries;Development;Devices;Diagnostic;Diagnostic Equipment;diagnostic tool;Disease;Dissociation;Dose;drug candidate;drug development;Ensure;Equilibrium;Erythrocytes;Face;Fetal Hemoglobin;Fostering;Future;Goals;Health;Health care facility;Healthcare;Hematology;Hemoglobin;Hemolysis;Hypoxia;image processing;improved;In Vitro;in vivo;innovation;inpatient service;Investigation;Investigational Drugs;Kinetics;Laboratories;Legal patent;manufacture;Marketing;Measurement;Measures;Mechanics;Medical;Membrane;Methods;Microscopy;Monitor;Morphology;new therapeutic target;Organ;Outcome;Oxygen;Pathway interactions;patient population;Patients;Performance;personalized medicine;Persons;Pharmaceutical Preparations;Pharmacology;Phase;point of care;Point-of-Care Systems;polymerization;Polymers;Prediction of Response to Therapy;Primary Care;Process;Production;prototype;Reactive Oxygen Species;real time monitoring;Research;Research Institute;Research Personnel;response;Risk;Sampling;Scanning;Sensitivity and Specificity;Severities;Sickle Cell;Sickle Cell Anemia;Sickle Cell Trait;sickling;Specific qualifier value;Standardization;success;Surrogate Endpoint;System;targeted treatment;Technology;Test Result;Testing;Therapeutic;therapeutic genome editing;therapy development;therapy outcome;Time;Tissues;tool;Translating;Treatment Efficacy;treatment response;Validation;vaso-occlusive crisis;Work

PROJECT_TITLE: Development of POC system for patient condition and treatment monitoring in Sickle Cell Disease through hypoxia-induced sickling

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IVBH-V (10)]


ADMINISTERING_IC: VA

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: Veterans Affairs

ORG_CITY: Aurora

ORG_NAME: VA EASTERN COLORADO HEALTH CARE SYSTEM

ORG_STATE: CO

PHR: The need for moral injury interventions is increasingly being recognized as a domain in Veteran care that must be addressed. Consequences of exposure to morally injurious events include risk for suicide, substance abuse, and refractory symptoms of PTSD and depression.1-5 Exposure to morally injurious events is also highly prevalent among Veterans.8-9 Thus, interventions addressing moral injury are crucial to helping Veterans build meaningful lives. Psychotherapies explicitly targeting moral injury and functional recovery associated with this construct are limited in VHA. The proposed study serves as a first step in addressing this gap in the literature through the development of a recovery-oriented, evidence-based treatment approach for moral injury among warzone Veterans who report functional impairments related to moral emotions. The proposed pilot study will evaluate the acceptability of this intervention and the feasibility of the design for a future study to test the treatment's capacity to improve patients' functioning.

PI_NAMEs: BARNES, SEAN ;BORGES, LAUREN  (contact)

PROJECT_TERMS: acceptability and feasibility;active control;Address;Aftercare;arm;authority;Behavior;Belief;Caring;Client satisfaction;Clinical;clinically significant;Cognition;community reintegration;Consent;Data;depressive symptoms;design;Development;Diagnostic;Disease;Distress;Dose;Educational process of instructing;efficacy study;efficacy testing;efficacy trial;Eligibility Determination;Emotions;Enrollment;Esthesia;Evaluation;Event;evidence base;Evidence based intervention;Evidence based treatment;experience;Exposure to;Feeling suicidal;follow up assessment;follow-up;Functional impairment;Future;Goals;high risk behavior;Impairment;improved;in vivo;Individual;Information Systems;injury recovery;interest;Intervention;Interview;Learning;Literature;Maintenance;Manuals;Measurement;Measures;Mental Depression;Military Personnel;military veteran;Moral injury;Morals;Nature;Outcome;Outcome Measure;Pain;Participant;Pathologic;Patient Outcomes Assessments;Patient Self-Report;Patients;Performance;Pilot Projects;Population;Post-Traumatic Stress Disorders;power analysis;provider adherence;psychologic;psychosocial;Psychotherapy;Questionnaires;Randomized;randomized controlled design;Randomized, Controlled Trials;Recovery;Recovery of Function;recruit;reduce symptoms;Refractory;rehabilitation research;Reporting;Research;research and development;Research Design;response;retention rate;Risk Factors;Sample Size;Self Care;Shame;skills;social;Social Functioning;social learning;Specific qualifier value;Spirituality;Structure;Substance abuse problem;substance use;suicidal behavior;suicidal risk;Symptoms;Syndrome;Testing;Thinking;Time;trial design;United States National Institutes of Health;Veterans;Visit;War;Work

PROJECT_TITLE: Thriving in the Midst of Moral Pain: The Acceptability and Feasibility of Acceptance and Commitment Therapy for Moral Injury (ACT-MI) Among Warzone Veterans

STUDY_SECTION_NAME: Behavioral Health & Social Reintegration[RRD4]


ORG_CITY: SAN DIEGO

ORG_NAME: VA SAN DIEGO HEALTHCARE SYSTEM

PHR: Insomnia is a common condition in Veterans, with prevalence rates as high as 53% among treatment-seeking Veterans. Chronic untreated insomnia is associated with increased risk for functional impairment, psychiatric illness, suicidal ideation, unhealthy lifestyles, and decreased quality of life. Cognitive-Behavioral Therapy for Insomnia (CBT-I) is recognized as the first-line treatment for insomnia. Despite its proven efficacy, CBT-I is not always readily provided and/or accessible to Veterans. To address these limitations, behavioral sleep medicine specialists have endeavored to streamline CBT-I through development of time-shortened variations of CBT-I. Although these modifications show promise for advancing care and access, studies comparing brief treatments to standard CBT-I have yet to be performed. This investigation will therefore compare a 4-session brief CBT-I to VA standard 6-session CBT-I to evaluate whether a brief intervention can provide comparable benefits to sleep, functional, and psychiatric outcomes in Veterans with insomnia.

PI_NAMEs: ORFF, HENRY JOHN (contact);PIGEON, WILFRED R

PROJECT_TERMS: Address;Aftercare;Alcohols;Alzheimer's Disease;anxiety symptoms;Area;awake;Beds;Behavioral;Bipolar Disorder;brief intervention;care seeking;Caring;Characteristics;Chronic;Chronic Insomnia;Clinic;Clinical;clinical practice;clinically significant;Cognitive Therapy;Columbidae;comparative effectiveness;Cross-Sectional Studies;Depressive disorder;Development;Diagnosis;Disease;Dissemination and Implementation;Distress;Drug Use Disorder;dual diagnosis;Education;Enrollment;Equation;Equipment and supply inventories;Evolution;Failure;falls;Feeling suicidal;Fingers;follow up assessment;follow-up;Freedom;Functional impairment;functional outcomes;Generalized Anxiety Disorder;Goals;Health;Healthcare Systems;high risk;Hour;Hybrids;Impairment;improved;indexing;Investigation;Left;Measures;Mediating;Medicine;Mental Depression;Mental disorders;Mental Health;Modeling;Modification;multi-component intervention;Observational Study;Occupational;operation;Outcome;Outcome Measure;Pain;Participant;Patients;personalized medicine;Persons;Phenotype;physical conditioning;physically handicapped;Population;Post-Traumatic Stress Disorders;Prevalence;Primary Care;psychosocial;psychosocial outcome;Quality of life;Questionnaires;Randomized;randomized, clinical trials;recruit;Rehabilitation Outcome;Relaxation Techniques;Reporting;Resources;Risk;Sampling;secondary analysis;Selection for Treatments;Severities;sex;Site;Sleep;Sleep Apnea Syndromes;Sleep Disorders;Sleep disturbances;sleep health;Sleeplessness;social;Specialist;standard care;Stimulus;success;suicidal;Suicide;symptomatology;Technology;Telemedicine;Testing;Time;timeline;treatment effect;treatment optimization;trial comparing;unhealthy lifestyle;United States Department of Veterans Affairs;Variant;Veterans;Veterans Health Administration;World Health Organization Disability Assessment Schedule

PROJECT_TITLE: A Randomized Clinical Trial Comparing Brief and Standard Cognitive-Behavioral Therapies for Insomnia in Veterans

STUDY_SECTION: RRDE

STUDY_SECTION_NAME: Behavioral Health & Social Reintegration[RRDE]


ADMINISTERING_IC: DE

ED_INST_TYPE: UNIVERSITY-WIDE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Digestive Diseases;Genetics;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: PROJECT NARRATIVE: Over 500,000 head and neck cancer patients receive therapeutic radiation each year, resulting in irreversible damage to the salivary glands, salivary hypofunction, and subsequent xerostomia (dry mouth syndrome). As current strategies to mitigate xerostomia fail to address the underlying mechanism of dysfunction, new therapies that long-term repair the injured gland are necessary to address this unmet clinical need. Given that Sox10 is involved in SG epithelial stem/progenitor cell self-renewal and differentiation processes, here we aim to determine whether Sox10 can induce plasticity in irradiated salivary gland ductal cells.

PI_NAMEs: JONES, CHRISTINA ELIZABETH-ROSE (contact)

PROGRAM_OFFICER_NAME: FUQUA, CHANTEL FAYSAN

PROJECT_TERMS: 3-Dimensional;Acinar Cell;Acinus organ component;Acute;Address;Adult;adverse outcome;Animal Model;Artificial Saliva;Atrophic;Attenuated;Binding;Bioinformatics;Cell Differentiation process;Cell Line;Cell Lineage;Cell Therapy;Cells;ChIP-seq;Chromatin;Chronic;Clinical;Complex;Cytomegalovirus;Data;Dose;Duct (organ) structure;Ductal Epithelial Cell;Epithelial Cells;epithelial stem cell;Exposure to;fibroblast growth factor receptor 2b;Fibroblasts;Fibrosis;Functional disorder;Gene Expression;gene network;Gene Targeting;Genes;Gland;Goals;head and neck cancer patient;Hydration status;Immunoprecipitation;in vivo;in vivo evaluation;Infusion procedures;injury and repair;irradiation;Link;Maps;Measures;Mediating;Messenger RNA;Modality;Molecular;mRNA Expression;Mus;Neural Crest;Neuroglia;novel therapeutics;Oral health;overexpression;Pathologic;Pathway interactions;Patients;Pharmaceutical Preparations;Phase;Plasmids;preservation;Process;progenitor;protein expression;Proteins;Quality of life;Radiation;radiation effect;Regulator Genes;repair strategy;repaired;Reporting;Research;Role;Saliva;Salivary;Salivary Glands;self-renewal;Signal Pathway;stem cell self renewal;stem cells;Stress;Syndrome;Therapeutic;Time;tissue regeneration;Tissues;transcription factor;transcriptome sequencing;translational therapeutics;Viral;Xerostomia

PROJECT_TITLE: Determining Sox10-mediated plasticity in irradiated salivary gland cells

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


ED_INST_TYPE: SCHOOLS OF MEDICINE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative

ORG_CITY: SALT LAKE CITY

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Project Narrative While our understanding of aging has greatly increased over the past few decades, treatments for and understanding of the pathogenesis of age-related diseases remain elusive. Recently, the ability of the lysosome (vacuole in yeast) to compartmentalize amino acids, particularly cysteine, was linked to mitochondrial dysfunction during the process of aging. In this study, we will investigate systems that collaborate with the vacuole to maintain cellular homeostasis during aging and also investigate this in a yeast model for Alzheimer’s disease.

PI_NAMEs: CHUI, KEVIN  (contact)

PROGRAM_OFFICER_NAME: OROSZ, ANDRAS

PROJECT_TERMS: abeta toxicity;Acidity;Acids;Affect;Age;age related;age-related disease;Aging;aging process;aging related;Alzheimer's Disease;Alzheimer's disease model;Amino Acid Transporter;Amino Acids;Amyloid beta-Protein;Area;Biological Assay;Biological Availability;Calcium ion;Catabolism;cell age;Cell Aging;cell growth;Cell membrane;Cell Physiology;Cell Survival;Cells;Cellular Metabolic Process;Collaborations;Cysteine;Cytoplasm;Cytoprotection;deletion library;Development;Disease;Down-Regulation;Drug Targeting;effective therapy;Endocytosis;Endoplasmic Reticulum;Event;experimental study;Functional disorder;Genes;Goals;Growth;hallmarks of aging;Haploidy;Healthcare;Homeostasis;Human;Incidence;Individual;Inductively Coupled Plasma Mass Spectrometry;innovation;Iron;life span;Link;lipid metabolism;lysosome membrane;Lysosomes;macromolecule;Malignant Neoplasms;Measures;Mediating;Membrane Transport Proteins;Metabolism;Microscopy;Mitochondria;mitochondrial dysfunction;Multivesicular Body;mutant;Nature;novel;Nutrient;Organelles;Oxidative Phosphorylation;Parkinson Disease;Pathogenesis;Pathway interactions;Pharmaceutical Preparations;Pilot Projects;Play;Process;Proteins;Proteome;Reactive Oxygen Species;Regulation;Research;response;Role;Saccharomyces cerevisiae;Saccharomycetales;Science;Signal Transduction;Site;Structure;Supplementation;System;Telomere Shortening;Testing;tool;Toxic effect;trafficking;uptake;vacuolar H+-ATPase;Vacuole;Western Blotting;Yeast Model System;Yeasts

PROJECT_TITLE: Investigating the Lysosome and Plasma Membrane Systems in Protecting Cells Against Age-induced Amino Acid Toxicity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-Q(20)L]


NIH_SPENDING_CATS: Aging;Bioengineering;Clinical Research;Neurosciences;Physical Injury - Accidents and Adverse Effects;Rehabilitation

ORG_CITY: CHAPEL HILL

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: RELEVANCE TO PUBLIC HEALTH This study will establish the cause-and-effect relationship of local muscle fatigability on walking stability through a combination of sophisticated motion capture and electromyographic time-frequency analyses with an innovative suite of walking balance perturbations designed to emulate real-world balance challenges. Through our approach, we will address several gaps that are currently impeding the field to have an immediate impact on our understanding of the directional dependence of fatigability on walking stability and on the influence of age and falls risk on the effects of local muscle fatigability. This work will also serve as a benchmark for underlying changes, in later research, neurological injury and neurodegenerative disease.

PI_NAMEs: SHELTON, ANDREW DOUGLAS (contact)

PROGRAM_OFFICER_NAME: JOSEPH, LYNDON

PROJECT_TERMS: Acceleration;Activities of Daily Living;Affect;Age;age effect;age related;age related decline;Aging;aging population;aging related;Area;Benchmarking;career;Cognitive;Collection;Communities;Compensation;Dependence;design;Development;Diagnostic;Economics;Electromyography;Equilibrium;evidence base;Exhibits;fall risk;falls;Fatigue;Fellowship;Frequencies;Funding;Gait;High Prevalence;Individual;innovation;insight;Intervention;Link;Measures;models and simulation;Monitor;Motion;Motor;Motor Activity;Muscle;Musculoskeletal;Musculoskeletal Equilibrium;Musculoskeletal Process;Nervous System Trauma;Neurodegenerative Disorders;Neuromechanics;neuromuscular;neurophysiology;novel;Observational Study;older adult;pre-doctoral;preservation;Public Health;Quality of life;recruit;Rehabilitation therapy;Research;Research Personnel;research study;response;Risk;Self-Help Devices;sensor;Sensory;simulation;skills;Speed;System;Technology;Testing;Time;Universities;Walking;walking stability;wearable device;wearable sensor technology;Work;young adult

PROJECT_TITLE: The Effects of Muscle Fatigability on Gait Instability in Aging and Age-Related Falls Risk


NIH_SPENDING_CATS: Aging;Charcot-Marie-Tooth Disease;Neurodegenerative;Neurosciences;Peripheral Neuropathy;Rare Diseases

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Project Narrative Maintenance of neuronal protein degradation through the endosomal-lysosomal pathway is essential for post-mitotic, aging neurons. Lysosomal membrane permeabilization (LMP) occurs commonly in aging related pathologies of the nervous system, but the cellular responses to disruption of the neuronal proteome during LMP are poorly understood. Identifying compensatory endosomal responses to LMP may allow us to develop novel therapeutic approaches for a vast number of neurological disorders that both affect the aging population and exhibit LMP pathology.

PI_NAMEs: MULLIGAN, RYAN J (contact)

PROGRAM_OFFICER_NAME: SARE, RACHEL

PROJECT_TERMS: Acceleration;Acute;Address;Affect;Age;age effect;age related;aged;Aging;aging population;aging related;Alleles;Alzheimer's Disease;Amputation;Apoptosis;ARHGEF5 gene;Autophagocytosis;Binding;Brain;Cell Death;Cell Membrane Permeability;cell type;Cells;Cessation of life;Charcot-Marie-Tooth Disease;Complex;Cytosol;Data;design;Disease;Distal;Endosomes;Enzymes;Esters;Event;Exhibits;experimental study;Exposure to;Extravasation;first responder;Galectin 3;Goals;GTP Binding;Guanosine Triphosphate;Guanosine Triphosphate Phosphohydrolases;Health;Heterozygote;Hour;Human;Hyperactivity;Image;Intraventricular;late endosome;Lead;Leucine;life span;Link;Lipofuscin;lysosomal proteins;Lysosomes;Maintenance;Mediating;Membrane;Monitor;Monomeric GTP-Binding Proteins;Motility;Motor;Mus;mutant;Mutation;Nature;Nervous System;Nervous System Disorder;Neurodegenerative Disorders;Neuroglia;neurological pathology;neuronal cell body;Neuronal Dysfunction;Neurons;neuropathology;novel;novel therapeutic intervention;Organelles;Organism;Pathology;Pathway interactions;Patients;Peripheral Nervous System Diseases;Population;postmitotic;prevent;Process;Property;protective pathway;protein degradation;Proteins;Proteome;Proteomics;proteostasis;proteotoxicity;Quality of life;recruit;repaired;response;Role;sensor;Sensory;Slice;Sorting;Stress;Stroke;Synapsins;System;Tamoxifen;tau Proteins;Testing;Therapeutic;Ulcer;Work

PROJECT_TITLE: Effects of Aging on Neuronal Lysosomal Damage Responses Driven by CMT2B-linked Rab7


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics

ORG_CITY: PHILADELPHIA

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project narrative: Although divergent transcription is estimated to occur at over 70% of active promoter regions throughout eukaryotes, the mechanism by which these divergent transcripts are generated remain a mystery. Using a bidirectional promoter composed of endogenous upstream activating sequence architecture and flanking core promoters, I observed that two preinitiation complexes (PICs) can dimerize in vitro via the coactivator Mediator complex. This proposal will determine the structure of the dimerized Mediator-PIC, a novel transcription complex, and its role in divergent transcription.

PI_NAMEs: PALAO, LEON  (contact)

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TERMS: 3-Dimensional;Architecture;Binding;Biological Assay;Biological Models;Brain;Cell Extracts;Cell Survival;Cells;Chromatin Modeling;Code;Complement;Complex;crosslink;Cryo-electron tomography;Cryoelectron Microscopy;Data;Development;dimer;Dimerization;Dissection;DNA;Eukaryota;Exhibits;experimental study;Galectin 1;Gene Expression;Genetic Transcription;Genome;global run on sequencing;Goals;Heart;Human;Hybrids;Image;In Vitro;innovation;knock-down;Lung;Mass Spectrum Analysis;Mediator;Methods;Modeling;Molecular;Mutation;novel;Nucleosomes;particle;Pathway interactions;Polymerase;preservation;Prevalence;Process;promoter;Promoter Regions;Proteins;reconstitution;recruit;Resolution;RNA Polymerase II;Role;single molecule;Structure;Tail;Transcript;Transcription Elongation;transcription factor;Transcriptional Regulation;Untranslated RNA;Yeasts

PROJECT_TITLE: Elucidating the Molecular Mechanism of Divergent Transcription


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: BOSTON

ORG_NAME: HARVARD MEDICAL SCHOOL

ORG_STATE: MA

PHR: Project Narrative Bacterial antibiotic persistence contributes to treatment failure, relapsing infections and selection of antibiotic resistance, yet mechanisms of persistence remain ill defined. In this project I will characterize properties and vulnerabilities of Salmonella persisters during infection to identify potential targets for their elimination. I will focus on the recent observation that chromosome accumulation confers a survival advantage to persisters and I aim at deciphering the benefit of such new genetic material.

PI_NAMEs: SARGEN, MOLLY RENEE (contact)

PROGRAM_OFFICER_NAME: ALEXANDER, WILLIAM A

PROJECT_TERMS: Affect;anti-microbial peptide;Antibiotic Resistance;Antibiotic Therapy;antibiotic tolerance;Antibiotics;antimicrobial;Antimicrobial Resistance;Bacteria;Biological Assay;Cell Cycle Regulation;Cell division;chromosome replication;Chromosomes;cost;Coupled;Development;DNA;DNA biosynthesis;DNA Damage;DNA Double Strand Break;DNA Repair;Double Strand Break Repair;Environment;Failure;fluorescence imaging;Frequencies;Gene Conversion;Genetic Materials;Genetic Transcription;Growth;homologous recombination;Immune response;Immune system;improved;Infection;insight;Knowledge;Laboratories;Link;Macrophage;Maintenance;Measures;Medicine;Methods;Mycobacterium tuberculosis;nutrient deprivation;pathogen;permissiveness;Phenotype;Plasmids;Ploidies;Population;prevent;Production;Property;Proteins;Reactive Nitrogen Species;Reactive Oxygen Species;recombinational repair;Relapse;repaired;Reporter;Research;response;Rest;Salmonella;Salmonella enterica;Salmonella infections;Staphylococcus aureus;Stress;Testing;therapy development;Time;Treatment Failure;treatment strategy;Variant

PROJECT_TITLE: The Dynamics of DNA in Salmonella Persisters in Macrophages


ADMINISTERING_IC: CK

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: National Center for Emerging and Zoonotic Infectious Diseases

ORG_CITY: LA JOLLA

ORG_NAME: J. CRAIG VENTER INSTITUTE, INC.

PHR: Project Narrative Two million people in the U.S. are diagnosed annually with life-threatening infections caused by antibiotic resistant bacteria that are responsible for 35,000 deaths each year with an economic impact estimated to be as much as $20 billion a year in direct healthcare costs. Due to the spread of antibiotic resistance, very few drugs remain that can treat these infections. The objectives of this Epicenter are to develop novel interventions that will prevent the colonization and spread of antibiotic resistant (AR) bacteria that cause hospital acquired infections (HAI), and to develop diagnostics and interventions to combat the colonization by the rapidly emerging fungal pathogen Candida auris.

PI_NAMEs: FOUTS, DERRICK E (contact)

PROJECT_TITLE: CK20-004, J. Craig Venter Insitute and Cleveland VA Prevention and Intervention Epicenter


ADMINISTERING_IC: DP

IC_NAME: NATIONAL CENTER FOR CHRONIC DISEASE PREVENTION AND HEALTH PROMOTION

ORG_CITY: SAIPAN

ORG_NAME: COMMONWEALTH HEALTHCARE CORPORATION

ORG_STATE: MP

PHR: Component A: Core Surveillance 5-year period of performance The Commonwealth of the Northern Mariana Islands Pregnancy Risk Assessment Monitoring System (CNMI PRAMS) PROJECT NARRATIVE The Commonwealth of the Northern Mariana Islands Pregnancy Risk Assessment System (CNMI PRAMS) is a surveillance project of the Centers for Disease Control and Prevention (CDC) and the Commonwealth Healthcare Corporation. The project collects information about maternal attitudes and experiences before, during, and after pregnancy. The data that will be available through the CNMI PRAMS is not available in any other data source and the results will be used to inform programs and policies aimed at reducing health problems among mothers and babies in the CNMI. Commonwealth of the Northern Mariana Islands Pregnancy Risk Assessment Monitoring System (CNMI PRAMS) RFA-DP-21-001

PI_NAMEs: PANGELINAN, HEATHER SANTOS (contact)

PROJECT_TITLE: PRAMS COMMONWEALTH HEALTHCARE CORPORATION


ADMINISTERING_IC: EY

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Bioengineering;Biotechnology;Eye Disease and Disorders of Vision;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

PHR: NARRATIVE While the vascular system in the retina is one of the most studied vascular beds, there remain significant knowledge gaps in our understanding of the processes that lead to retinal vascular dysfunction. However, there are no in vitro perfusable models of the iBRB that can be used to assess pathological conditions. Here we propose establishing 3D human iBRB models, including a post‑capillary venule (~100 µm diameter) model and a capillary plexus (<50 µm diameter), and incorporate additional functionalities, including oxygen tension and matrix mechanics to create models with physiological characteristics as healthy functioning tissues.

PI_NAMEs: GERECHT, SHARON  (contact)

PROGRAM_OFFICER_NAME: GORDIYENKO, NATALIYA

PROJECT_TERMS: 3-Dimensional;Acceleration;Address;age related changes;Aging;aging population;angiogenesis;arteriole;Astrocytes;Biocompatible Materials;Biological Assay;Blood capillaries;Blood Vessels;Blood-Retinal Barrier;Cells;Cellular Morphology;Cellular Structures;Characteristics;Clinical Research;collaborative environment;Collagen;Development;Diabetic Retinopathy;Diameter;Dimensions;Disease;Disease Progression;Endothelial Cells;Engineering;Ensure;Environment;Exposure to;extracellular;Eye;fabrication;Foundations;Functional disorder;Future;Gene Expression;Genetic Transcription;Health;Homeostasis;Human;human induced pluripotent stem cells;Hydrogels;Hypoxia;Image;Immunofluorescence Immunologic;In Vitro;in vitro Model;Individual;induced pluripotent stem cell;Injury;innovation;Ischemia;Knowledge;Location;Mechanics;Mediating;meter;microphysiology system;mimetics;mimicry;Modeling;Muller's cell;neural;Neurosciences Research;next generation;novel therapeutics;Older Population;Oxygen;Pathologic;Performance;Perfusion;Pericytes;Permeability;Phenotype;Physiological;Play;postcapillary venule;Process;protein expression;Protocols documentation;response;Retina;Retinal Vein Occlusion;Role;Serum;shear stress;stem cells;Structure;Supporting Cell;System;Techniques;Tissue Engineering;Tissues;Universities;Validation;vascular bed;Vascular Diseases;Vascular Permeabilities;Vascular System;venule;Western Blotting;Work

PROJECT_TITLE: Engineering three-dimensional perfusable microphysiological models of the human inner blood-retina barrier

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-B (80)]


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Genetics;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza

ORG_CITY: CHESTNUT HILL

ORG_DEPT: BIOLOGY

ORG_NAME: BOSTON COLLEGE

PHR: Project Narrative: Streptococcus pneumoniae is an important pathogen carried asymptomatically by a large proportion of the population that exhibits a transition to virulence characterized by a complex gene expression program. Small non-coding RNAs (sRNAs) are often critical mediators of virulence in bacteria, but are under characterized in S. pneumoniae. This research will identify mRNA targets for sRNAs necessary for virulence to illuminate the regulatory pathways leading to virulence.

PI_NAMEs: MEYER, MICHELLE MARGARET (contact)

PROGRAM_OFFICER_NAME: UPADHYAY, MEENU MISHRA

PROJECT_TERMS: Acute;Affinity Chromatography;Antibiotic Resistance;Antibiotic Therapy;Bacteremia;Bacteria;Bacterial Physiology;biological adaptation to stress;Biological Assay;Biological Process;Biology;Carbon;Cataloging;Child;Competence;Complex;computerized tools;Coupled;crosslink;Data;Defect;ear infection;Escherichia coli;Exhibits;Exonuclease;experimental study;fitness;Gene Expression;Genes;Goals;Gram-Negative Bacteria;Gram-Positive Bacteria;High-Throughput Nucleotide Sequencing;Immunoprecipitation;Individual;Infection;Ligation;Mediating;Mediator;Meningitis;Messenger RNA;Modeling;Molecular Chaperones;Mus;Nucleotides;Organism;Otitis Media;Outcome;pathogen;Pathogenicity;Play;Pneumonia;Population;prediction algorithm;predictive tools;Prevalence;priority pathogen;Process;programs;Property;Proteins;Regulator Genes;Regulatory Pathway;Reporter;Reporter Genes;Research;response;RNA;RNA-Binding Proteins;Role;Salmonella enterica;Serotyping;Small RNA;Streptococcus pneumoniae;Stress;Surveys;Techniques;Therapeutic Intervention;Thermodynamics;transcriptome sequencing;transposon sequencing;United States;Untranslated RNA;Vaccines;Validation;Virulence;Work

PROJECT_TITLE: Interrogation of the sRNA regulatory network mediating virulence of Streptococcus pneumoniae

STUDY_SECTION: PCMB

STUDY_SECTION_NAME: Prokaryotic Cell and Molecular Biology Study Section[PCMB]


NIH_SPENDING_CATS: Bioengineering;Breast Cancer;Cancer;Colorectal Cancer;Digestive Diseases;Immunotherapy;Lung;Lung Cancer;Nanotechnology;Women's Health Research

ORG_CITY: MARTINEZ

ORG_NAME: CHEMEDIMMUNE, INC.

ORG_STATE: GA

PHR: Project Narrative  This project will determine the efficacy and toxicology of the the lipid nanoparticle-encapsulated IFN2- encoding mini-plasmid DNA (IFNA2-LNP01) for treatment of cancer patients with lung metastases. The proposed studies are expected to generate sufficient efficacy and toxicology data for a Phase II IND-enabling study of IFNA2-LNP01.

PI_NAMEs: REDD, PRISCILLA SIMON (contact)

PROGRAM_OFFICER_NAME: REGMI, SAROJ GOPAL

PROJECT_TERMS: 4T1;Adverse effects;Affect;Biodistribution;Cancer Patient;cancer therapy;chemokine;Clinical;colon cancer patients;Colon Carcinoma;Colonic Neoplasms;COVID-19;CT26;curative treatments;CXCL10 gene;CXCL9 gene;Cytotoxic T-Lymphocytes;Data;design;Development;Disease;DNA;Dose;efficacy evaluation;Eligibility Determination;Encapsulated;Excision;FDA approved;fighting;Frequencies;Generations;Growth;Half-Life;Human;human disease;humanized mouse;IFNA2 gene;Immune Evasion;Immunotherapy;Impairment;in vivo;Interferon Type I;Left;Life;lipid nanoparticle;Literature;Lung;Lung Neoplasms;Malignant Neoplasms;Melanoma;Messenger RNA;Metastatic Neoplasm to the Lung;Modeling;mouse model;Mus;Myeloid Cells;Neoadjuvant Therapy;Neoplasm Metastasis;neoplastic cell;Nucleic Acids;Operative Surgical Procedures;Organ;Pathway interactions;patient derived xenograft model;patient population;Patients;PD-1 blockade;Phase;phase 2 study;plasmid DNA;Polyethylene Glycols;Polymers;Population;programmed cell death ligand 1;programmed cell death protein 1;Proteins;Publishing;Recombinant Proteins;recruit;Repression;Risk;RNA vaccine;Signal Pathway;Site;STAT1 gene;success;Survival Rate;systemic toxicity;T-Lymphocyte;Testing;Time;Toxicology;treatment response;triple-negative invasive breast carcinoma;tumor;Tumor Suppression;Tumor Suppressor Proteins;Tumor-Infiltrating Lymphocytes;ViraferonPeg

PROJECT_TITLE: Development of IFNA2-LNP01 for tumor lung metastases immunotherapy


ADMINISTERING_IC: HD

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Biotechnology;Regenerative Medicine

ORG_CITY: East Greenwich

ORG_NAME: GORDON RESEARCH CONFERENCES

ORG_STATE: RI

PHR: Project Narrative The goal of the proposed Gordon Research Conference (GRC) and Gordon Research Seminar (GRS) on Notch Signaling in Development, Regeneration and Disease is to provide a stimulating, international and cross disciplinary forum for the dissemination and discussion of new unpublished research, concepts, and therapeutic opportunities at the forefront of Notch-related biology. The Notch signaling pathway is a central mediator of short- range inter-cellular communication in multicellular organisms, and alterations of Notch activity cause or contribute to a growing list of human developmental syndromes, adult onset diseases and cancers, expanding the interest in this pathway well beyond the boundaries of basic developmental and cell biology and into the areas of stem cell biology, cancer biology and therapeutics. Building on past success of the conference, the 6th Notch GRC/GRS will bring together a diverse community of scientists from academia, biotech and the pharmaceutical industry working in multiple model organisms and organ systems, including researchers focused on human disease, to create a stimulating scientific environment where cutting edge technologies, ideas and discoveries can be exchanged and where students and research fellows will gain exposure to leaders in the field.

PI_NAMEs: HALTIWANGER, ROBERT S. (contact)

PROGRAM_OFFICER_NAME: TOYAMA, REIKO

PROJECT_TERMS: Academia;Acceleration;Address;Adult;Alagille Syndrome;American;anti-cancer therapeutic;Antibodies;aortic valve disorder;Area;Biology;Biotechnology;Body System;CADASIL;Cancer Biology;cancer initiation;Cardiovascular Diseases;career;Career Mobility;Cells;Cellular biology;Clinic;Clinical;Clinical Trials;Cloning;cohesion;Collaborations;college;commune;Communities;cost;COVID-19;Creativeness;Cues;Data;Development;Developmental Biology;Developmental Therapeutics Program;Disease;Drosophila genus;Drug Industry;Dysostoses;Education;Environment;Event;experience;Exposure to;Faculty;faculty mentor;Fertilization;Fostering;frontier;Future;Genes;Genetic study;Genetic Transcription;genome-wide;Goals;graduate student;Health;Heart;Homeostasis;Human;human disease;Human Genetics;Immune;Industry;Inflammatory;inhibitor;innovation;insight;Institution;intercellular communication;interest;International;Knowledge;Ligands;Location;Maine;malformation;Malignant Neoplasms;Mediator;meetings;member;Memory;Metabolic;Metabolic Diseases;model organism;Molecular;Mutation;Natural regeneration;notch protein;Notch Signaling Pathway;novel therapeutic intervention;novel therapeutics;Onset of illness;Organism;Participant;Pathology;Pathway interactions;Phenotype;Physicians;Physics;Physiology;Post-Translational Protein Processing;Postdoctoral Fellow;posters;programs;Proteolysis;receptor;Receptor Gene;Research;Research Personnel;Role;Scientist;Signal Pathway;Signal Transduction;stem cell biology;structural biology;Student Selections;Students;success;symposium;Syndrome;synergism;Technology;Therapeutic;Time;Tissues;Toxic effect;Training;translational potential;Travel;tumor;tumor progression

PROJECT_TITLE: 2024 Notch Signaling in Development, Regeneration and Disease Gordon Research Conference and Gordon Research Seminar

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Developmental Biology Study Section[CHHD-C]


ADMINISTERING_IC: HG

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Atherosclerosis;Cardiovascular;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Heart Disease - Coronary Heart Disease;Human Genome;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: BALTIMORE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Cutting-edge methods provide a new means of using genetics to understand causal relationships between biomarkers and disease but perform poorly in marginalized populations especially burdened by complex diseases. We will leverage a polygenic risk score to understand the validity of a genetic causal inference method in diverse populations, incorporating possible ancestry, clinical, and environmental interactions. This work will create a framework that extends genetic tools to better understand what causes disease across populations.

PI_NAMEs: SHARMA, JAYATI  (contact)

PROGRAM_OFFICER_NAME: RIVERS, ROBERT C

PROJECT_TERMS: Accounting;Address;Adult;Affect;Age;Air;Air Pollution;All of Us Research Program;Architecture;base;Biological Factors;Biological Markers;burden of illness;Cardiovascular system;Case Study;Cause of Death;Clinical;clinical predictors;clinical risk;clinically relevant;cohort;Complex;Coronary Arteriosclerosis;Data;Development;Diet;Disease;disorder prevention;doctoral student;Environment;Environmental Exposure;Environmental Risk Factor;Epidemiologist;Epidemiology;epidemiology study;Equity;Ethnic Population;Etiology;European ancestry;Evaluation;experience;Fellowship;Genes;Genetic;genetic epidemiology;Genetic Models;Genetic Risk;genome-wide;Genomics;Goals;Health;health care availability;health care disparity;Heart Diseases;Heterogeneity;improved;Individual;Influentials;instrument;Laboratories;LDL Cholesterol Lipoproteins;Linear Regressions;Literature;marginalized population;Measures;Mendelian randomization;Mentors;Methods;Modeling;Modification;mortality;multi-ethnic;National Human Genome Research Institute;non-genetic;novel;Observational epidemiology;Observational Study;Outcome;Participant;Pathway interactions;Performance;Phenotype;Physical activity;polygenic risk score;Polygenic Traits;Population;Population Heterogeneity;predictive modeling;predictive tools;Prevention;Public Health;Public Health Schools;racial population;Randomized, Controlled Trials;Research;Research Design;Research Training;Risk Factors;risk prediction;Role;Sampling;Smoking;social factors;sociodemographic factors;structural determinants;Sum;tool;Training Programs;trait;United States;Variant;whole genome;Work

PROJECT_TITLE: Evaluation of Polygenic Risk Scores as a Valid Instrument to Conduct Mendelian Randomization in Diverse Ancestry Populations

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F08-L (20)]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: RALEIGH

ORG_NAME: PREDICTIVE, LLC

PHR: There are emerging FDA directives to restrict and, eventually, eliminate animal testing of medical and cosmetic products and integrate alternative New Approach Methods (NAMs) into regulatory programs. However, such evaluation still relies on time-consuming and expensive animal testing. To address this yet unmet need, in Phase II of this project, we will create novel computational toolkit and web-based resource to evaluate the toxicity of medical devices for sensitization, irritation, and cytotoxicity.

PI_NAMEs: GOLBRAIKH, ALEXANDER  (contact)

PROGRAM_OFFICER_NAME: RAVICHANDRAN, LINGAMANAIDU V

PROJECT_TERMS: Active Learning;Address;Adverse effects;Animal Testing;Animals;Bayesian Modeling;Biological Assay;Cavia;CCL4 gene;chemical safety;Chemicals;Commercial grade;commercialization;computational platform;Computer Models;Computer software;computerized tools;Consensus;Consumption;Corrosion;Cosmetics;cost;cytotoxicity;cytotoxicity test;Data;data curation;Data Set;Databases;deep learning;Descriptor;design;Development;Devices;Economics;Electronic Mail;Evaluation;functional group;Future;Generations;Human;Hypersensitivity skin testing;Implant;In Vitro;in vivo;Individual;interest;International;Internet;irritation;Laboratories;Licensing;Local Lymph Node Assay;machine learning algorithm;machine learning model;machine learning prediction;Medical;Medical Device;Methods;model development;Modeling;Modernization;monolayer;Mus;novel;novel strategies;online resource;Outcome;Phase;phase 2 study;product development;programs;Publishing;Pythons;Qualifying;Quantitative Structure-Activity Relationship;Radiologic Health;Reporting;research and development;safety assessment;Science;Secure;Services;Skin;skin irritation;software as a service;software development;Structure;Testing;Time;tool;Toxic effect;Validation;web app;web platform;web portal;web site;Work

PROJECT_TITLE: Development of a web-based platform implementing novel Predictor of Toxicity for Medical Devices (PredTox/MD)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-B (14)]


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences;Regenerative Medicine;Wound Healing and Care

ORG_CITY: LOUISVILLE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF LOUISVILLE

PHR: Project Narrative The proposed research is relevant to public health because the integrity of the corneal epithelium is frequently compromised as the result of trauma, surgery, side-effects of anti-cancer drugs, and as a complication of multiple diseases including diabetes and autoimmune disorders. Identifying the molecular mechanisms that regulate the integrity of the corneal epithelium is the first step in developing therapies that promote the homeostasis and regeneration of the corneal epithelium before vision becomes jeopardized. This project is relevant to the NEI’s mission to support research with respect to the molecular basis of visual function and the preservation of sight.

PI_NAMEs: TARVESTAD LAISE, KATE  (contact)

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: Acceleration;afferent nerve;Anatomy;Anterior;Antineoplastic Agents;Autoimmune Diseases;Axon;axon growth;Back;Binding;Biochemical;Biological Assay;Biology;Blindness;Brain;CBL gene;Cell Line;cell motility;Cell Proliferation;Chemicals;Cicatrix;Complication;Comprehension;Cornea;corneal epithelial wound healing;corneal epithelium;Corneal Injury;Corneal Opacity;corneal regeneration;cytokine;Cytokine Receptors;Descemet's membrane;desensitization;Diabetes Mellitus;Disease;Down-Regulation;Dryness;Endothelium;Environment;Epithelial Cells;epithelial injury;Epithelium;epithelium regeneration;expectation;Eye;Family;FDA approved;Fibroblasts;Fibrosis;Foreign Bodies;Genetic;Goals;Growth;Growth Factor;healing;Health;Healthcare;HGF gene;Homeostasis;Human;Human body;improved;In Vitro;in vivo;in vivo Model;Incidence;Infection;Infectious Agent;Inflammation;Inflammation Mediators;Inflammatory;inflammatory marker;innovation;Intervention;intraepithelial;Knock-out;Knockout Mice;Ligands;Light;Measures;Medical;migration;Mission;Modeling;Molecular;Monitor;Morphology;mouse model;National Eye Institute;Nerve;Nerve Fibers;Nerve Regeneration;nerve supply;neuronal growth;Nutrient;Operative Surgical Procedures;Oxygen;Pain;pathogen;Patients;Peripheral Nerves;Pharmaceutical Preparations;Pharmacodynamics;pharmacologic;Phenotype;Phosphorylation;Physiology;preservation;prevent;Process;Proliferating;Proteins;Public Health;Quality of life;re-epithelialization;receptor;Receptor Protein-Tyrosine Kinases;Receptor Signaling;Recurrence;Regulation;Research;Research Support;response;restoration;Retina;Role;Sensory;side effect;Signal Pathway;Signal Transduction;Structure;System;Tamoxifen;Temperature;Testing;Therapeutic;therapy development;Tissues;trafficking;transmission process;Trauma;Trigeminal nerve structure;ubiquitin-protein ligase;Vision;wound;wound healing

PROJECT_TITLE: Optimizing c-Met signaling to enhance corneal epithelial homeostasis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F05-Q (20)]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: PROJECT NARRATIVE Systemic Lupus Erythematosus and its associated cutaneous lupus lesions remain difficult to treat and are driven by dysregulation of type I interferon production. This project will uncover novel mechanisms that regulate the production of type I IFNs in the skin, the interactions between skin-derived interferons, and how therapies that target type I IFNS impact the changes in skin biology in SLE patients to develop new preventative and therapeutic strategies for this devastating disease. Discoveries made through this research are directly relevant to the NIH's mission to foster fundamental discoveries and their applications to protect and improve public health.

PI_NAMEs: KAHLENBERG, JOANNE MICHELLE (contact)

PROGRAM_OFFICER_NAME: MANCINI, MARIE

PROJECT_TERMS: Autoimmune Diseases;Autoimmunity;Binding;Biology;Cell Death;Cells;chemokine;Chronic;Critical Pathways;Cutaneous;cytokine;Data;Dendritic Cells;Development;Disease;DNA;DNA Binding;Environment;Epigenetic Process;Family;Fostering;Funding;Genetic Transcription;Goals;Grant;Helper-Inducer T-Lymphocyte;Human;IFNAR1 gene;Immune;Immune response;improved;Inflammation;Inflammatory;Inflammatory Response;Interferon Type I;Interferon Type II;Interferon-beta;Interferons;keratinocyte;knock-down;Knock-out;Learning;Lesion;Lupus;lupus cutaneous;Mediating;Mission;Mitochondria;Mitochondrial DNA;mitochondrial dysfunction;Molecular Conformation;Mus;Myelogenous;Myeloid Cells;new therapeutic target;novel;nucleic acid binding protein;Nucleic Acids;oxidation;Pathogenesis;Pathway interactions;Patients;Pattern;Peripheral;Pharmaceutical Preparations;Phenotype;Population;prevent;Production;Public Health;recruit;Refractory;Refractory Disease;Regulation;Repression;Research;Research Design;response;Risk;Role;Signal Transduction;Skin;skin disorder;Source;Stress;Systemic disease;systemic inflammatory response;Systemic Lupus Erythematosus;T cell response;targeted treatment;Therapeutic;Therapeutic Intervention;transmission process;Treatment outcome;Ultraviolet B Radiation;Ultraviolet Rays;United States National Institutes of Health;Up-Regulation;Work;Z-DNA Binding Protein;Z-Form DNA

PROJECT_TITLE: Characterization of interferon kappa as a novel target in cutaneous lupus

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MSOS-L (02)]


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Biotechnology;Clinical Research;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Prevention;Sexually Transmitted Infections;Social Determinants of Health

ORG_CITY: Madison

ORG_NAME: SALUS DISCOVERY, LLC

ORG_STATE: WI

PHR: PROJECT NARRATIVE The ongoing epidemic of sexually transmitted infections (STIs), particularly in men who have sex with men, is worsening as the fear of HIV and the acceptance/use of barrier methods decreases. STI diagnostics are the critical gateway to treatment and technology for point-of-care (POC) STI tests that can be accessed at local clinics and performed by “lay health workers” during the patient visit are needed to address ongoing STI socioeconomic health disparities. This project overcomes current limitations using a simple (3 step), cheap, and fast, assay for ultra-sensitive detection of STIs at the POC and efforts include first optimizing the assay to enable detection of even the lowest level infections and then testing performance using clinical samples.

PI_NAMEs: MULLINS, BRIANNA  (contact);WARRICK, JAY WYATT

PROGRAM_OFFICER_NAME: GLOCK, JONATHAN A

PROJECT_TERMS: Address;antigen test;Anus;Barrier Contraception;Benchmarking;Biological Assay;Chemistry;Chlamydia trachomatis;Clinic;Clinical;Collaborations;Complex;condoms;cost;Country;Cytology;Data;design;Detection;Development;Devices;Diagnosis;Diagnostic;Disparity;Doctor of Philosophy;economic disparity;Electronics;Epidemic;Exclusion;Fright;Goals;Health;health disparity;Health Insurance;high risk;HIV;Human Papillomavirus;Human papillomavirus 16;Human papillomavirus 18;Individual;Infection;Infection Control;Infection prevention;Injections;invention;Laboratories;Malignant neoplasm of anus;Malignant Neoplasms;manufacture;men who have sex with men;Methodology;Methods;Microfluidics;Molds;neighborhood disadvantage;Neisseria gonorrhoeae;novel;Nucleic Acid Amplification Tests;Nucleic Acids;operation;Oral;pathogen;Patients;Performance;performance tests;Phase;point of care;Point of Care Technology;point of care testing;Population;Preparation;Prevention;Procedures;Process;Pump;recruit;sample collection;Sampling;screening;seal;sexually active;Sexually Transmitted Diseases;socioeconomics;Specificity;Swab;Technology;Testing;Time;Translating;Tube;Tuberculosis;Universities;Vaccines;Virus;Visit;wasting;Wisconsin

PROJECT_TITLE: 3STEP: A swab-seal-read, point-of-care nucleic acid test to address disparity in STI screening and prevention

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 DCAI-Y (13)]


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: INDIANAPOLIS

ORG_DEPT: GENETICS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: PROJECT NARRATIVE In this project, we will apply advanced statistical and AI methods to identify human genetic variants that are associated with cellular and tissue morphology. The results can serve as baselines for disease pathology research. This work will also enhance our understanding about how genomic information determines tissue development and differentiation.

PI_NAMEs: HUANG, KUN ;ZHANG, JIE  (contact)

PROGRAM_OFFICER_NAME: MASKERI, BAISHALI

PROJECT_TERMS: Bioinformatics;Biomedical Research;Cell Communication;Cell Physiology;cell type;Cells;Cellular Morphology;Clinical;clinical practice;Complex;Computational algorithm;Computer software;Computer Vision Systems;Data;Data Set;deep learning;Detection;Development;Diagnosis;Disease;Disease Marker;Ethnic Origin;Event;functional genomics;Gender;General Population;Genes;Genetic;genetic information;Genetic study;genetic variant;genome wide association study;Genomics;Genotype-Tissue Expression Project;Goals;histological image;Histology;Histopathology;Human BioMolecular Atlas Program;Human Genetics;Image;insight;Investigation;Left;Link;Machine Learning;Malignant Neoplasms;Methods;Microscopic;Molecular;Morphology;multi-ethnic;Normal tissue morphology;novel;organ growth;pathogen genome;Pathologic;Pathologist;Pathology;Pathway interactions;Pattern;Phenotype;polygenic risk score;Population;Process;Quantitative Trait Loci;rare variant;Research;Resolution;Resources;Role;Sampling;Series;Solid;Testing;Texture;The Cancer Genome Atlas;Tissue Differentiation;Tissues;tool;trait;transcriptome;United States National Institutes of Health;user-friendly;Variant;Visualization;web portal;whole slide imaging;Work

PROJECT_TITLE: Apply novel pathogenomic approaches to identify interpretable image QTLs for multiple normal tissues

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BBBT-F (02)]


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cardiovascular;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Hematology;Human Genome;Lung;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research;Sleep Research;Social Determinants of Health

ORG_DEPT: DENTISTRY

PHR: PROJECT NARRATIVE A significant contributor to the unsettling fact that cardiovascular diseases kill almost twice as many Black adults compared to White adults in the United States, is the lack of equitable population representation in genomic studies. I propose to address this significant shortcoming by using an African ancestry-focused approach to identify genetic variations associated with heart, lung, blood, and sleep phenotypes and elucidate how both individual and local ancestry contributes to disease risk. This work has the potential to expand our knowledge of genetic risk in a historically under-represented population and advance the development of effective and equitable precision medicine technologies.

PI_NAMEs: ZHANG, DAVID  (contact)

PROGRAM_OFFICER_NAME: MEADOWS, TAWANNA

PROJECT_TERMS: Address;Adopted;Adult;Advanced Development;African American;African American population;African ancestry;All of Us Research Program;Automobile Driving;base;biobank;Biological;Biological Models;Black race;Blood;Blood specimen;Cardiovascular Diseases;Catalogs;Cessation of life;Chi-Square Tests;Classification;Clinical;clinical practice;Code;Cohort Studies;Consent;Dangerousness;Data;Databases;Development;Diagnosis;diagnostic development;Disease;disorder risk;Disparity;dosage;Electronic Health Record;Equity;Ethnic Origin;European;European ancestry;exome;exome sequencing;Future;Gene Expression;Gene Frequency;Genes;Genetic;genetic association;Genetic Research;Genetic Risk;Genetic study;genetic variant;Genetic Variation;Genome;genome wide association study;genomic locus;Genomics;Genotype;Goals;Haplotypes;health care disparity;health disparity;Heart;heart disease risk;Heart Diseases;Hematological Disease;Individual;Institution;interest;Investigation;Knowledge;loss of function;Lung;Lung Diseases;Medical;medical schools;Medicine;Methods;Minor;mortality;Participant;participant enrollment;Pathway interactions;patient subsets;Patients;Pennsylvania;personalized care;personalized medicine;Persons;phenome;Phenotype;Play;polygenic risk score;Population;Population Heterogeneity;precision medicine;Prevalence;protein structure;Proteins;public database;rare variant;Recontacts;recruit;repository;risk variant;Role;Sleep;Sleep Disorders;social health determinants;socioeconomics;Technology;Therapeutic;trait;Trans-Omics for Precision Medicine;Translating;trend;Underrepresented Populations;United States;Universities;Variant;Veterans;Vision;Work

PROJECT_TITLE: Investigating ancestry-specific genetic variation associated with HLBS phenotypes in diverse patient biobanks


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: PROJECT NARRATIVE Processing visual information is a key nervous system function for many animals. However, understanding the neural computations that underlie visual processing has been difficult due to large variability in these circuits. The aim of this proposal is to leverage modern electrophysiological and computational approaches to map and probe the distributed brain network underlying visual processing.

PI_NAMEs: LI, ANNA  (contact)

PROGRAM_OFFICER_NAME: CLAYTON, EDWIN C

PROJECT_TERMS: Accounting;Animals;Anterior;Area;area striata;Attention;Behavior;behavior measurement;Biophysical Process;Brain;brain computer interface;Brain Mapping;Brain region;career;Characteristics;Code;Communities;Complex;computational neuroscience;Computer Analysis;Computer Models;Computing Methodologies;Corpus striatum structure;Coupled;Data;Data Analyses;Data Set;density;Development;Dimensions;Distant;Electrophysiology (science);Environment;experimental study;Eye Movements;Face;Fellowship;flexibility;frontal lobe;Generations;Goals;Head;Histologic;Image;improved;innovation;Learning;Light;Locomotion;Maps;Measures;Mentors;Microscopy;Modeling;Modernization;Monitor;motor behavior;Mus;Nature;Neocortex;Nervous System Physiology;neural;neural circuit;Neurons;Neurosciences;Noise;Organism;Pattern;Photic Stimulation;Process;Regression Analysis;Research Personnel;Resources;response;Scheme;Sensory;sensory neuroscience;Sensory Process;skills;Source;Stimulus;Structure;superior colliculus Corpora quadrigemina;System;Techniques;Testing;Thalamic structure;Therapeutic;Training;Triplet Multiple Birth;V1 neuron;Vision;Visual;Visual Cortex;visual information;Visual Pathways;visual processing

PROJECT_TITLE: The distributed basis of visual cortical variability

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F02B-Y (20)]


NIH_SPENDING_CATS: Contraception/Reproduction;Infectious Diseases;Microbiome;Sexually Transmitted Infections;Women's Health Research

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PHR: PROJECT NARRATIVE Chlamydia trachomatis (CT) is the most common bacterial sexually transmitted infection in the US; consequences of untreated CT include pelvic inflammatory disease, ectopic pregnancy, and increased healthcare costs. This proposal will assess how the cervicovaginal metagenome and immune response contribute to rapid spontaneous CT clearance (without antibiotics) because CT clearance likely provides the greatest protection against reproductive sequelae when it happens early in infection. Findings from this work will identify potential therapeutic targets to promote rapid CT clearance, which can ultimately be translated into antibiotic-sparing CT treatments, and inform CT vaccine design.

PI_NAMEs: CARTER, KAYLA A (contact)

PROGRAM_OFFICER_NAME: VINCENT, LEAH REBECCA

PROJECT_TERMS: Acceleration;Age;aged;Anaerobic Bacteria;Anti-Inflammatory Agents;Antibiotic Therapy;Antibiotics;Archives;Bacteria;Bacterial Vaginosis;Bioinformatics;Biological Response Modifier Therapy;Cell Adhesion;cervicovaginal;cervicovaginal microbiome;Chlamydia trachomatis;Chronic;chronic infection;cohort;Compensation;Complex;Data;design;Development;Ectopic Pregnancy;Environment;Epidemiology;Event;Fostering;Genitourinary system;Growth;Guidelines;Health Care Costs;Immune;Immune response;Immunity;Immunologic Markers;Immunology;In Vitro;Individual;Indoles;Infection;Infertility;Inflammation;innovation;insight;Interferon Type II;Interruption;Intervention;Knowledge;Lactic acid;Lactobacillus;Lavage;Longitudinal Studies;Mammalian Oviducts;Mediating;Metabolic;Metabolic Clearance Rate;metagenome;Metagenomics;microbiome;microbiome analysis;microbiota;Modeling;multiple omics;novel;novel strategies;Parents;Pathology;Pelvic Inflammatory Disease;Play;Population;post-doctoral training;prevent;Production;prospective;reproductive;reproductive tract;Resolution;response;Risk;Role;Sampling;screening;sexually active;Sexually Transmitted Diseases;Testing;therapeutic target;tool;Translating;United States National Institutes of Health;Vaccine Design;vaccine development;Vaccines;Vagina;vaginal lactobacilli;vaginal microbiome;vaginal microbiota;Visit;Woman;Work

PROJECT_TITLE: Prospective contributions of the vaginal microbiome and immune milieu to spontaneous Chlamydia trachomatis clearance

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F07A-B (20)]


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Infectious Diseases;Orphan Drug;Prevention;Rare Diseases;Sexually Transmitted Infections

ORG_CITY: LEXINGTON

ORG_NAME: MEDCHEM PARTNERS, LLC

PHR: PROJECT NARRATIVE While Herpes simplex virus (HSV) can affect any part of the eye, in the U.S. alone, 30,000 people suffer from recurrent corneal HSV-1 involvement – Herpes simplex keratitis (HSK). In addition to risk of severe vision loss, HSK impacts quality of life and poses a significant economic burden. A 2003 study estimated a cost of 17.7 million dollars annually due to HSK. Page 1 of 1

PI_NAMEs: LAZAROVA, TSVETELINA IVANONOVA (contact);ST LEGER, ANTHONY J

PROGRAM_OFFICER_NAME: GOVER, TONY DOUGLAS

PROJECT_TERMS: Abbreviations;absorption;Acyclovir;Adrenal Cortex Hormones;Adult;Affect;Africa;analog;Anti-viral Agents;Biological Assay;Blindness;C57BL/6 Mouse;Capsid;Caring;Cells;Chemicals;Clathrin;Clinical;Clinical Trials;Cornea;Corneal Ulcer;cost;Cytoprotection;Data;Development;DNA biosynthesis;dosage;Dose;Drug Kinetics;Drug resistance;Dry Eye Syndromes;Dynamin;Economic Burden;efficacy evaluation;Encephalitis;Endocytosis;Epidemic;Epithelial Cells;Epithelium;Excretory function;Eye;eye dryness;Eye Infections;Family;Formulation;genital herpes;Goals;Guanosine Triphosphate Phosphohydrolases;Herpes Simplex Infections;Herpes Simplex Virus Vaccines;Herpesvirus 1;Herpetic Keratitis;HIV;Human;Human Herpesvirus 2;Hydrogen Peroxide;Immunocompromised Host;Infection;Inflammation;Inflammatory;Keratoplasty;Lead;lead optimization;Libraries;Life;Life Cycle Stages;limbal;Measurement;Mediating;Metabolism;Morbidity - disease rate;mouse model;Mucous Membrane;neonate;novel;novel virus;ocular surface;Pathway interactions;Persons;Pharmaceutical Preparations;Phase;pleiotropism;preservation;prevent;Prevention strategy;Prodrugs;Property;Quality of life;Recurrence;Risk;scale up;seropositive;side effect;Simplexvirus;small molecule;Steroids;Structure of trigeminal ganglion;Structure-Activity Relationship;Testing;Therapeutic;therapy development;Tissues;trafficking;transmission process;trend;United States;uptake;Viral;viral DNA;viral transmission;Virus;Virus Diseases;Virus Shedding;Vision;Visual;Visual Acuity

PROJECT_TITLE: Combating Corneal HSV Infection with Novel Dynasore Analogues

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-M (12)]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Obesity;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Pediatric;Prevention;Social Determinants of Health;Women's Health Research

ORG_NAME: DREXEL UNIVERSITY

PHR: PROJECT NARRATIVE Food insecurity—inadequate access to enough food for every person in a household to live an active, healthy life—threatens critical early childhood growth and can put children at risk for poor short- and long-term health. Understanding how factors at multiple levels (household, neighborhood, policy) influence how food insecurity affects child weight over time is important for developing evidence-based policies and interventions to reduce food insecurity and reduce disparities in child weight outcomes. The goal of the proposed mixed-methods study is to inform implementation of WIC and other food assistance policies by using focus groups and statistical analyses to examine how household food insecurity is associated with weight trajectories among young children, and how this association is modified by neighborhood environment and public food assistance programs.

PI_NAMEs: LE-SCHERBAN, FELICE  (contact)

PROGRAM_OFFICER_NAME: UNALP-ARIDA, AYNUR

PROJECT_TERMS: Affect;Age;aged;American;Area;Behavior;Black race;Breast Feeding;Caregivers;Certification;Characteristics;Child;Child Care;Child health equity;Childhood;Communities;community violence;Complex;cost;Counseling;COVID-19 pandemic;Data;Data Analyses;Development;Diet;disparity reduction;early childhood;Economics;Effectiveness;Electronic Health Record;Electronics;Eligibility Determination;Environment;evidence base;Evidence based program;experience;Family;family influence;family support;Fatty acid glycerol esters;feeding;flexibility;Focus Groups;Food;Food Access;Food Assistance Programs;food insecurity;Food Packaging;fruits and vegetables;Goals;Growth;Health;Health behavior and outcomes;Health Food;healthy weight;Household;improved;Individual;Inequity;Infant;innovation;Integrated Delivery Systems;Intervention;Latinx;Life;Link;Low income;Methods;metropolitan;Modeling;Modernization;Mothers;Neighborhoods;Nutrient;Nutritional;obesity risk;Office Visits;Outcome;outcome disparities;outreach;overweight child;pandemic disease;Patients;Pediatric Hospitals;Persons;Philadelphia;Policies;Postpartum Period;pregnant;programs;Recommendation;Recovery;Reporting;Research;Restaurants;Risk;Schools;Source;Special Supplemental Nutrition Program for Women, Infants, and Children;Statistical Data Interpretation;sugar;Surveys;System;Time;Weight;Weight Gain;Woman

PROJECT_TITLE: Food Insecurity, Neighborhood Environment, and Weight Trajectories in Young Children: Implications for Food Assistance Policy

STUDY_SECTION: CIHB

STUDY_SECTION_NAME: Community Influences on Health Behavior Study Section[CIHB]


ORG_CITY: VANCOUVER

ORG_COUNTRY: CANADA

ORG_FIPS: CA

ORG_NAME: PROVINCIAL HEALTH SERVICES AUTHORITY

ORG_STATE: BC

ORG_ZIPCODE: V5Z 4E6

PHR: Project Narrative A new blood test (miR371) appears to be highly accurate in predicting active germ cell tumors. Current clinical tests such as CT scans and standard tumor markers appear less accurate than miR371 and can lead to misdiagnosis of active germ cell malignancy, overtreatment and unnecessary treatments and significant expense and toxicity. We are proposing a clinical investigation to evaluate the ability of miR371 testing compared to or integrated with CT scan images to reduce, replace or potentiate the use of the current clinical tools and reduce the exposure of patients to unnecessary and somewhat toxic interventions.

PI_NAMEs: NAPPI, LUCIA  (contact)

PROGRAM_OFFICER_NAME: MARQUEZ, GUILLERMO

PROJECT_TERMS: Adolescent and Young Adult;Adult;Back;base;Behavior;biobank;Biological;Biological Assay;Biological Markers;Biometry;Blood Tests;cancer care;care delivery;Cell Cycle Regulation;Characteristics;Childhood;Clinical;Clinical assessments;clinical care;Clinical Data;clinical investigation;clinical practice;clinical predictive model;Clinical Research;Clinical Trials;cohort;Collaborations;Communities;Consensus;cost;cost effective;Coupled;Data;design;Detection;Development;Diagnosis;diagnostic biomarker;Division of Cancer Prevention;early detection biomarkers;Embryonic Development;embryonic stem cell;Epigenetic Process;Family;follow-up;Germ cell tumor;Germ Cells;gonad development;Gonadal structure;Image;improved;Individual;innovation;International;Intervention;Lead;Lesion;Liquid substance;Malignant Neoplasms;Measures;Methodology;Methods;MicroRNAs;Molecular;Nonseminomatous;North America;overexpression;overtreatment;participant enrollment;patient oriented;patient population;Patients;Plasma;Play;pluripotency;Population;Positioning Attribute;Post-Transcriptional Regulation;pre-clinical;predictive modeling;Pregnancy;prenatal;prevent;primary endpoint;Process;prospective;pubertal timing;Quality of life;Radiation therapy;radiological imaging;Relapse;repository;Research Design;Research Project Grants;Research Proposals;Resource-limited setting;Reverse Transcriptase Polymerase Chain Reaction;Role;Sampling;Seminoma;Sensitivity and Specificity;side effect;Solid;Southwest Oncology Group;Specificity;Specimen;standard of care;Statistical Data Interpretation;statistics;stemness;Survivors;Techniques;Testing;therapeutic target;Time;Tissues;tool;Toxic effect;trial design;tumor;Tumor Markers;unnecessary treatment;Untranslated RNA;virtual;X-Ray Computed Tomography

PROJECT_TITLE: Integrating investigational miR371a-3p with conventional radiology imaging for earlier and more precise detection of active germ cell malignancy: A BCC/SWOG/S1823 secondary use of data collaboration.


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Lung;Pneumonia and Influenza;Vaccine Related

ORG_CITY: ATLANTA

ORG_DEPT: MISCELLANEOUS

ORG_NAME: GEORGIA STATE UNIVERSITY

PHR: Project Narrative - Relevance to Public Health Influenza virus infection represents a major cause of morbidity and mortality. Despite currently available vaccines and antiviral drugs which have a limited impact, there is still an urgent need for developing novel therapeutic agent to improve innate immunity based on full understanding of the molecular mechanisms underlying tight regulation of innate immunity in influenza virus infection. The currently proposed studies will lead to the identification of novel therapeutic targets and development of new therapeutic strategy for influenza virus infection.

PI_NAMEs: LI, JIAN-DONG  (contact)

PROGRAM_OFFICER_NAME: ARNOLD, MICHELLE MARIE

PROJECT_TERMS: airway epithelium;Anti-viral Agents;Anti-viral Response;Cessation of life;Communicable Diseases;Complex;Data;Development;Disease;drug resistant virus;dsRNA adenosine deaminase;Epidemic;Epithelial Cells;Fibrosis;Foundations;Genes;Goals;improved;In Vitro;Infection;Inflammatory;influenza infection;influenza virus vaccine;influenzavirus;Innate Immune Response;innovation;Interferon Type I;IRF3 gene;Lung;lung injury;Malignant Neoplasms;Mediating;Molecular;Morbidity - disease rate;mortality;mouse model;mutant;Natural Immunity;new therapeutic target;novel therapeutic intervention;novel therapeutics;Nuclear Protein;pathogen;Pathogenesis;pharmacologic;Phosphoglycerate Kinase;Play;Public Health;ran GTP-Binding Protein;receptor;Regulation;Role;Seasons;SHPS-1 protein;Signal Pathway;Signal Transduction;Solid;Testing;Therapeutic;Therapeutic Agents;therapeutic development;translational potential;Tretinoin;vaccine access;Vaccines;Viral;Viral Genes;Virus;virus identification

PROJECT_TITLE: Negative regulation of innate immunity in influenza virus infection

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 AIRT-J (01)]


ORG_CITY: NEW ORLEANS

ORG_DEPT: PHYSIOLOGY

ORG_NAME: LSU HEALTH SCIENCES CENTER

ORG_STATE: LA

PHR: PROJECT NARRATIVE The goal of the LSUHSC-NO PREP is to prepare individuals from backgrounds underrepresented in the biomedical sciences, who have recently completed their baccalaureate science degrees, for successful enrollment, retention, and completion of a Ph.D. training program. We aim to enhance the diversity of the biomedical research workforce by preparing PREP Scholars for the rigors and challenges of a biomedical doctoral degree program so that they will successfully obtain a Ph.D. degree and contribute their expertise to the biomedical scientific community.

PI_NAMEs: HARRISON-BERNARD, LISA M. (contact)

PROGRAM_OFFICER_NAME: STEPANEK, LAURIE ELIZABETH

PROJECT_TERMS: Academia;Academic Training;anxiety reduction;Applications Grants;Bachelor's Degree;Basic Science;Biological;Biomedical Research;career;career development;Centers of Research Excellence;Clinical Sciences;Communities;Community Outreach;community science;Critical Thinking;Data Analyses;Degree program;design;Development;Development Plans;Disabled Persons;Doctor of Philosophy;Doctor's Degree;doctoral student;Education;education research;Educational workshop;Eligibility Determination;empowerment;Enrollment;Environment;Equilibrium;Equity;Ethics;Exclusion;Exercise;experience;Extramural Activities;Faculty;faculty mentor;faculty research;Financial Support;Fostering;Foundations;Funding;Funding Mechanisms;Goals;graduate school;graduate student;Health Sciences;high school;Historically Black Colleges and Universities;improved;Individual;innovation;Institution;Interview;Knowledge;Laboratory Research;Learning;Louisiana;Manuscripts;Master of Science;Medical;Medicine;member;Mentors;Methodology;Oral;Pathway interactions;Persons;Postbaccalaureate;Postdoctoral Fellow;posters;pre-doctoral;Program Development;programs;Public Health;recruit;Reproducibility;Research;Research Ethics;research faculty;Research Project Grants;Research Training;Resources;Rewards;role model;Scholars Program;Science;science education;Scientist;skill acquisition;skills;socioeconomic disadvantage;Solid;statistical learning;Statistical Methods;statistics;Structure;Students;Study Skills;success;summer program;summer research;symposium;Technical Expertise;Testing;Time Management;Training;Training Programs;undergraduate student;underrepresented minority student;Underrepresented Populations;Underrepresented Students;United States National Institutes of Health;Universities;Visit;Writing

PROJECT_TITLE: LSUHSC-New Orleans Postbaccalaureate Research Education Program in Biomedical Sciences

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - C[TWD-C]


NIH_SPENDING_CATS: Biotechnology;Cancer;Childhood Leukemia;Gene Therapy;Genetics;Hematology;Immunotherapy;Lymphatic Research;Lymphoma;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: Aurora

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF COLORADO DENVER

PHR: PROJECT NARRATIVE Despite the effectiveness of CAR T therapy for patients with refractory B cell malignancies, approximately 50% of patients relapse within one year of treatment. A common cause of relapse is the emergence of CAR-resistant leukemias. Our proposal develops two key models for studying mechanisms of relapse following cellular therapy for leukemia and identifies avenues for improving durability of remission.

PI_NAMEs: ERNST, PATRICIA  (contact);FRY, TERRY J.

PROGRAM_OFFICER_NAME: WATSON, JOANNA M

PROJECT_TERMS: Adoptive Cell Transfers;Adult;Affect;Antigens;B lymphoid malignancy;B-Cell Acute Lymphoblastic Leukemia;B-cell precursor acute lymphoblastic leukemia cell;B-Lymphocytes;bcr-abl Fusion Proteins;Biological Models;Biology;Blocking Antibodies;Bone Marrow;cancer cell;Cancer Model;cancer therapy;CD19 Antigens;CD19 gene;Cell Communication;Cell Line;Cell Reprogramming;Cell Therapy;Cells;Characteristics;Childhood;Childhood Precursor B Lymphoblastic Leukemia;chimeric antigen receptor;Coupled;CRISPR/Cas technology;curative treatments;cytokine;Cytokine Signaling;cytotoxic;Data;design;Development;Disease remission;Effectiveness;Environment;Epigenetic Process;Epithelium;Evolution;Exhibits;Frequencies;Gene Expression Profile;Genetic;genetically modified cells;Genomics;Hematologic Neoplasms;Hematopoiesis;Heterogeneity;Immune;immune checkpoint blockade;Immune checkpoint inhibitor;Immunologics;Immunotherapeutic agent;Immunotherapy;improved;in vivo;Infant;Inflammatory;inflammatory modulation;innovation;Interleukin-1;Interleukin-6;Intervention;Intrinsic factor;Knockout Mice;leukemia;leukemia treatment;Lymphoma;Malignant Neoplasms;MLL gene;MLL-rearranged leukemia;Modeling;molecular targeted therapies;mouse model;Mouse Strains;Multiple Myeloma;Myelogenous;Newborn Infant;novel;novel strategies;Pathogenesis;Patients;Pattern;Phenotype;phenotypic biomarker;pressure;prevent;Production;programs;Protocols documentation;Receptor Cell;Refractory;Relapse;relapse patients;Remission Induction;Resistance;response;Role;Signal Pathway;Signal Transduction;Site;Solid Neoplasm;Study models;Surface Antigens;System;T-Lymphocyte;TCF3 gene;Testing;Therapeutic;therapeutic target;transplant model;tumor

PROJECT_TITLE: Escape from CAR T surveillance through lineage plasticity


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Kidney Disease;Lymphatic Research;Nanotechnology

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Project Narrative The current standard treatment for the severe inflammatory condition affecting the kidney known as crescentic glomerulonephritis involves the use of systemic immunosuppressive agents, which cause toxicity that can result in death. This proposal seeks to understand better how the immune system becomes activated in the kidney-draining lymph node during crescentic glomerulonephritis in mice and to develop a novel treatment platform consisting of a nanoparticle that delivers immunosuppressive agents selectively to the kidney-draining lymph node. We predict that delivering immunosuppressive agents selectively to the kidney-draining lymph node with this nanoparticle will treat crescentic glomerulonephritis more effectively as well as reduce the toxicity caused by conventional systemic therapy, a finding that could provide a springboard for the use of this nanoparticle in future clinical trials involving human patients. !

PI_NAMEs: KASINATH, VIVEK  (contact)

PROGRAM_OFFICER_NAME: RANKIN, TRACY L

PROJECT_TERMS: Ablation;adaptive immune response;Adopted;Adoption;Affect;Antibodies;antibody conjugate;Antigen-Presenting Cells;Binding;Blood Vessels;Boston;career;career development;CCL19 gene;CCL21 gene;CD4 Positive T Lymphocytes;CDW52 gene;cell mediated immune response;cell motility;Cell Proliferation;Cell secretion;Cells;Cessation of life;chemokine;Clinical;Clinical Trials;combat;Crescentic Glomerulonephritis;Data;Development;Development Plans;Dialysis procedure;dosage;draining lymph node;Drug Delivery Systems;effector T cell;efficacy evaluation;Engineering;Extracellular Matrix;Fiber;Funding;Future;Goals;Grant;High Endothelial Venule;Homing;Hospitals;Human;Immune;immune activation;Immune response;Immune system;Immunologist;Immunology;Immunosuppressive Agents;improved;In Vitro;Infection;Inflammatory;inflammatory milieu;Injury to Kidney;insight;instructor;KDR gene;Kidney;Kidney Failure;Laboratories;Left;Leukocytes;lymph nodes;Lymphangiogenesis;Lymphatic;lymphatic vasculature;lymphatic vessel;lymphotoxin beta receptor;Measures;medical schools;Medicine;Mentors;Mentorship;Monoclonal Antibodies;mouse model;multidisciplinary;Mus;nanoparticle;nanoparticle delivery;nanopolymer;nanotherapeutic;Nephritis;nephrotoxicity;new therapeutic target;novel;novel therapeutic intervention;Pathogenesis;Patients;Permeability;Phenotype;Physicians;Population;precision medicine;Production;Proliferating;Publishing;Receptor Signaling;Records;renal damage;Renal glomerular disease;Reperfusion Injury;Research;Research Personnel;Reticular Cell;Role;scaffold;Scientist;Serum;side effect;Signal Pathway;Site;skills;Spleen;standard care;Stromal Cells;Surface;Systemic Therapy;T-Lymphocyte;targeted delivery;Testing;Therapeutic Agents;Therapeutic immunosuppression;Toxic effect;Transplantation;United States National Institutes of Health;Universities;Vascular Endothelial Growth Factors;Woman

PROJECT_TITLE: Role of Kidney-Draining Lymph Node in Crescentic Glomerulonephritis

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


ORG_STATE: WA

PHR: NIEHS recognizes that promoting healthier lives involves discovering how the environment affects people. It is essential that the workers making these discoveries represent everyone, including individuals who are traditionally underrepresented. The SURE-EH program will provide research experience and educational opportunities in the environmental health sciences to University of Washington undergraduate students from traditionally underrepresented backgrounds.

PI_NAMEs: SHEPPARD, ELIZABETH A  LIANNE (contact)

PROGRAM_OFFICER_NAME: HUMBLE, MICHAEL C

PROJECT_TERMS: Affect;Biomedical Research;Caliber;Complement;Disabled Persons;disadvantaged background;Discipline;Diverse Workforce;economic disparity;Education;Educational Activities;Educational workshop;educationally disadvantaged;empowerment;Ensure;Environment;Environmental Health;Environmental Science;Essential worker;Ethics;Ethnic Population;experience;Faculty;Future;Goals;Graduate Education;graduate school;health science research;Individual;Institution;Learning;Mission;National Institute of Environmental Health Sciences;Participant;Persons;Positioning Attribute;programs;Qualifying;racial population;Recommendation;Research;Research Project Grants;Research Training;responsible research conduct;Science;Scientist;skills;social;Strategic Planning;Students;symposium;Training;Training Programs;undergraduate research experience;undergraduate student;Underrepresented Students;Universities;Washington

PROJECT_TITLE: Supporting Undergraduate Research Experiences in Environmental Health (SURE-EH)


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Cervical Cancer;Clinical Research;Prevention;Radiation Oncology;Women's Health Research

ORG_CITY: LA JOLLA

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: Project Narrative The proposed research is relevant to public health because cervical cancer is a common cause of cancer amongst women and treatment decisions are based heavily on accurate and early imaging. By developing a technique that evaluates response to treatment earlier than the current standard of care, we will decrease morbidity and mortality by treating cervical cancer at an earlier time point, preventing further progression of disease. The development of new biomedical imaging techniques to fundamentally improve the detection and treatment of disease is directly relevant to one of the key missions of the NIH.

PI_NAMEs: RAKOW-PENNER, REBECCA ANN (contact)

PROGRAM_OFFICER_NAME: GRODZINSKI, PIOTR

PROJECT_TERMS: Access to Information;Affect;Aftercare;Age;Agreement;Algorithms;Benign;Biological Markers;biomedical imaging;biophysical model;biophysical properties;Bladder;Brain;Cancer Etiology;cancer imaging;Cancer Patient;Cervical;Cervical Cancer Screening;Cervix Uteri;Cessation of life;chemoradiation;Chemotherapy and/or radiation;Classification;classification algorithm;Clinical;clinically significant;cohort;contrast enhanced;Contrast Media;Data;Detection;Development;Diagnosis;Diffusion;Diffusion Magnetic Resonance Imaging;Disease;Disease Progression;Early treatment;Edema;Evaluation;Free Will;Functional disorder;Gold;Hemorrhage;Hysterectomy;Image;imaging modality;Imaging Techniques;improved;Indolent;Infertility;Inflammation;innovation;Intestines;Lesion;Machine Learning;magnetic field;Magnetic Resonance Imaging;Malignant - descriptor;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Manuals;Measures;Methods;Mission;Modeling;Morbidity - disease rate;Morphologic artifacts;mortality;nerve injury;novel strategies;Organ;Outcome;Patient Care;Patients;Pelvic Pain;Performance;Pilot Projects;Positron-Emission Tomography;prevent;Property;prospective;Prostate;Public Health;Radiation;radiation response;Radiation therapy;radical hysterectomy;Reader;Research;response;Restriction Spectrum Imaging;Sampling;screening program;Sensitivity and Specificity;Signal Transduction;Source;Staging;standard of care;Standardization;Structure;Techniques;Testing;theories;Therapeutic;Time;Tissues;tool;Translating;Treatment Efficacy;treatment planning;treatment response;tumor;Tumor Burden;Tumor Tissue;United States National Institutes of Health;uptake;Visualization software;Water;water diffusion;Woman;Women's mortality;Work;X-Ray Computed Tomography

PROJECT_TITLE: Advanced diffusion MRI for evaluating early response to radiation treatment in cervical cancer

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


NIH_SPENDING_CATS: Diabetes;Nutrition;Obesity

ORG_CITY: BATON ROUGE

ORG_NAME: LSU PENNINGTON BIOMEDICAL RESEARCH CTR

PHR: The prevalence of obesity and diabetes mellitus in the United States places an enormous national burden on the health care system. The proposed studies address a critical need to understand the signal-specific regulatory strategies used to promote growth and control insulin secretion in the islet beta-cell population. The results of this project will expedite the development of novel and highly specific salutary approaches to improve metabolic health and reduce health care costs.

PI_NAMEs: COLLIER, JAMES JASON (contact)

PROGRAM_OFFICER_NAME: HWA, ALBERT J

PROJECT_TERMS: Address;Anabolism;Automobile Driving;Beta Cell;Biochemical Pathway;Biological Assay;Calcium;Cell Cycle;cell growth;Cell Proliferation;Cells;cellular targeting;Collaborations;Coupling;Cues;cytokine;Data;design;detection of nutrient;Development;Diabetes Mellitus;Diagnosis;Electrophysiology (science);Event;Exposure to;Fatty acid glycerol esters;feeding;Future;Gene Expression;gene network;Generations;Genes;Genetic;Glucocorticoids;Glucose;glucose tolerance;Goals;Growth;Health;Health Care Costs;Healthcare Systems;Human;Image;improved;In Vitro;in vivo;Infusion procedures;insight;Insulin;Insulin Resistance;insulin secretion;islet;Link;Lipids;Mediating;Metabolic;Metabolic Diseases;metabolomics;Molecular;mouse model;Mus;novel;Nutrient;Nutritional;Obesity;Outcome;oxidation;Oxygen Consumption;Pathway interactions;Pentosephosphates;Phosphotransferases;Population;Prediabetes syndrome;Prevalence;Process;Proliferating;Publishing;Purines;Pyrimidine;Regulation;response;Rodent;sensor;Serum;Signal Induction;Signal Transduction;Solid;Source;stable isotope;stem cells;Stimulus;Structure of beta Cell of islet;Techniques;Testing;therapy design;Tracer;transcriptome sequencing;translational impact;United States

PROJECT_TITLE: SGK1 is a regulator of islet beta cell mass and secretory function


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Cancer;Brain Disorders;Cancer;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Rare Diseases

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: Project Narrative Knowledge of molecular status for a variety of markers in gliomas has moved to the forefront in clinical decision- making. This requires direct tissue sampling either from an invasive brain biopsy or open surgical resection. In this Bioengineering Research Grant proposal in response to PAR-19-158, we will develop and validate a non- invasive method to determine a panel of the most critical molecular markers (IDH, 1p/19q and MGMT methylation) with near tissue-level accuracies using routine T2-weighted (T2w) MR images and deep learning algorithms to significantly reduce and in many cases eliminate the need for stereotactic biopsy in glioma.

PI_NAMEs: MALDJIAN, JOSEPH A (contact)

PROGRAM_OFFICER_NAME: BEIER, HOPE THOMAS

PROJECT_TERMS: 19q;Acceleration;Algorithms;Applications Grants;Artificial Intelligence;Automation;Biology;Biomedical Engineering;Biopsy;Brain;Brain Neoplasms;Classification;Clinical;clinical decision-making;clinical implementation;clinical translation;Computerized Medical Record;contrast imaging;cost;Craniotomy;Data;Data Set;Databases;deep learning;deep learning algorithm;Digital Imaging and Communications in Medicine;Excision;experience;Glioma;Goals;Human;Hyperacusis;Image;improved;Institution;Knowledge;large datasets;learning classifier;Magnetic Resonance Imaging;Manuals;Medical center;Methods;Methylation;MGMT gene;Molecular;Molecular Analysis;molecular marker;Morphologic artifacts;Motion;motion sensitivity;mutational status;Neurosurgical Procedures;Noise;novel;Operative Surgical Procedures;Patient Care;Patient-Focused Outcomes;Patients;Performance;Predictive Value;Procedures;Process;Prognosis;prospective;Prospective cohort;Reporting;Research Project Grants;Resources;response;Risk;Sample Size;Specificity;surgical risk;T2 weighted imaging;Testing;The Cancer Genome Atlas;The Cancer Imaging Archive;Time;Tissue Sample;Tissues;tool;Training;tumor;Tumor Tissue;United States National Institutes of Health;Validation;virtual biopsy;Work

PROJECT_TITLE: Virtual Biopsy with Tissue-level Accuracy in Glioma

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]