NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Genetics;Lung;Rare Diseases;Sarcoidosis

ORG_CITY: DENVER

ORG_NAME: NATIONAL JEWISH HEALTH

ORG_STATE: CO

PHR: PROJECT NARRATIVE The reason why some patients develop progressive lung involvement in sarcoidosis, have unrelenting symptoms and worsening lung function and others don’t, is not well understood. This proposal will define factors that may explain why some people get progressive sarcoidosis while also establishing new proteins, genes, markers and a potential tool to detect persistent or progressive lung inflammation and worsening lung function. In future studies, these factors may be tested clinically as tests or predictors of disease and ultimately even targets for therapy.

PI_NAMEs: BHARGAVA, MANEESH ;CROUSER, ELLIOTT D;LEACH, SONIA ;MAIER, LISA A (contact)

PROGRAM_OFFICER_NAME: VUGA, LOUIS J

PROJECT_TERMS: Address;Affect;Area;Automobile Driving;Bioinformatics;Biological;Biological Markers;biological systems;Biology;Blood;Body System;Cells;Characteristics;Clinical;clinical decision-making;Clinical Management;clinical trial enrollment;Clinical Trials;cohort;Complex;Country;Cytometry;Data;Decision Making;Development;digital;Disease;disease model;Disease Progression;Disease Resistance;disorder control;Early identification;Early treatment;Educational workshop;Enrollment;Event;follow-up;follower of religion Jewish;Foundations;FRAP1 gene;Funding;Future;Gene Expression Profile;Genes;genetic signature;Genetic Transcription;Goals;Granuloma;Granulomatous;Granulomatous disease;Health;high risk;Human;IL8 gene;improved;In Vitro;in vitro Model;Individual;Inflammation;innovation;insight;Investigation;Knowledge;Laboratories;Link;Location;longitudinal care;Lung;Lung nodule;Messenger RNA;Methods;Minnesota;Modeling;Molecular;Molecular Profiling;molecular subtypes;Morbidity - disease rate;mortality;mRNA Expression;multiple omics;National Heart, Lung, and Blood Institute;Natural Killer Cells;novel;novel strategies;Ohio;Outcome;outcome prediction;Pathologic;Pathway interactions;Patient Care;Patient Outcomes Assessments;Patients;Peripheral Blood Mononuclear Cell;Persons;Phagosomes;Phenotype;Plasma;Plasma Proteins;Population;predictive modeling;progression risk;Progressive Disease;prospective;protein expression;Proteins;Proteomics;Proxy;pulmonary function;Pulmonary Inflammation;Pulmonary Sarcoidosis;recruit;Research;Research Personnel;Research Priority;Respiratory Failure;Risk;Sampling;Sarcoidosis;Severities;Signal Transduction;single-cell RNA sequencing;Symptoms;Systems Biology;targeted treatment;Testing;Therapeutic;therapeutic target;Tissues;tool;transcriptome sequencing;translational study;United States National Institutes of Health;Universities;Validation;Whole Blood

PROJECT_TITLE: Molecular Characterization of Progressive Pulmonary Sarcoidosis

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


ADMINISTERING_IC: GM

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Cancer

ORG_CITY: ANN ARBOR

ORG_COUNTRY: UNITED STATES

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative: We will study the dynamics of the signaling cascade that activates the mitotic checkpoint and develop a mathematic model to understand and predict the behavior of the mechanisms underlying the signaling cascade. We will use this understanding to investigate how aberrant checkpoint signaling increases the frequency of chromosome missegregation in cancerous cells.

PI_NAMEs: JOGLEKAR, AJIT  (contact)

PROGRAM_OFFICER_NAME: MILLER, RITA K

PROJECT_TERMS: Anaphase;behavior prediction;Behavioral Mechanisms;biological systems;cancer cell;Cancerous;Cell Cycle Regulation;Cell division;Cells;Cellular biology;chromosome missegregation;Chromosome Segregation;data modeling;Ensure;Experimental Models;Frequencies;Genomic Instability;Goals;Kinetochores;mathematical model;Mitotic Checkpoint;Nature;Process;recruit;Signal Transduction;Signaling Protein;Systems Biology;Theoretical model

PROJECT_TITLE: The systems biology of mitotic checkpoint signaling and its relevance to cancer cell biology

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Coronaviruses;Emerging Infectious Diseases;Genetics;Human Genome;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza

ORG_CITY: Columbus

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative There is growing evidence the canine coronaviruses (CCoVs) can infect and be associated with clinical disease in humans. We propose studies to identify genomic features associated with CCoV spread to humans and to determine the functional role of some unique genomic features of a novel CCoV isolated from an infant with pneumonia using next generation sequencing, phylogenetic, molecular clock and phenetic analyses, reverse genetics and transcriptomics approaches.

PI_NAMEs: DECARO, NICOLA ;VLASOVA, ANASTASIA NICKOLAEVNA (contact)

PROGRAM_OFFICER_NAME: PARK, EUN-CHUNG

PROJECT_TERMS: 2019-nCoV;Acute;Address;Adult;Affect;Biological;Biological Process;Canis familiaris;Cells;Child;Chiroptera;Clinical;Collaborations;Collection;comparative;Coronavirus;Coronavirus nucleocapsid protein;Country;Disease;Evolution;Family Felidae;Family suidae;Genbank;Genes;Genetic;Genetic Markers;Genome;genome sequencing;genome-wide;genome-wide analysis;genomic data;genomic RNA;Genomics;Genotype;geographically distant;Haiti;high risk;Human;human pathogen;Immune;Immune response;Infant;Infection;Innate Immune Response;Interferon Type I;Interferons;Knowledge;Malaysia;Modeling;Molecular;Molecular Biology;molecular clock;Mutation;next generation sequencing;novel;Pathogenicity;Patients;Phenotype;Phosphorylation;Phylogenetic Analysis;Play;Pneumonia;Population;Production;Proteins;Public Health;Recombinants;respiratory;response;reverse genetics;RNA Binding;Role;SARS coronavirus;SARS-CoV N protein;Signal Transduction;Syndrome;Thailand;trait;transcriptome;transcriptomics;transmission process;Virion;Virus;Zoonoses

PROJECT_TITLE: Origin and host adaptation of the novel canine coronavirus (CCoV-HuPn-2018) isolated from a human pneumonia patient

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIA-S(02)]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics;Immunotherapy;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: COLUMBUS

ORG_NAME: RESEARCH INST NATIONWIDE CHILDREN'S HOSP

PHR: NARRATIVE The overarching aim of this study is to determine the mechanisms behind the highly successful treatment combination of trabectedin, an FDA-approved drug, and an antitumor virus against Ewing sarcoma and osteosarcoma tumors. This study will contribute critical insights into how tumor-specific viral infection and trabectedin work together advantageously to achieve tumor cell death. Discoveries from this study on how this treatment combination targets tumor vulnerabilities could prove generalizable to other cancers, rationalize clinical trials, and provide new therapeutic options for cancer.

PI_NAMEs: RINGWALT, EMILY  (contact)

PROGRAM_OFFICER_NAME: PURI, ANU

PROJECT_TERMS: Address;advanced disease;Anti-viral Response;antitumor effect;Apoptosis;Binding;bone;cancer therapy;cancer type;CASP8 and FADD-like apoptosis regulating protein;CASP8 gene;Cell Death;Cells;Cessation of life;Childhood;childhood sarcoma;clinical application;Clinical Trials;Color;Combined Modality Therapy;comparative efficacy;CRISPR/Cas technology;Cytokine Signaling;Cytolysis;Cytometry;cytotoxic;cytotoxicity;Data;Data Analyses;Development;DNA Binding Agent;Ensure;Enzyme-Linked Immunosorbent Assay;Ewings sarcoma;Exhibits;expectation;FDA approved;Future;Gene Expression;gene product;Genetic Transcription;Human;Immunocompetent;immunodeficiency;Immunofluorescence Immunologic;Immunologic Stimulation;Immunosuppression;immunosuppressive macrophages;improved;In complete remission;in vivo;Infection;inhibitor;innovation;insight;Interferons;Knock-out;Label;Lead;Macrophage;Malignant Neoplasms;Mediating;Methods;Modeling;Monitor;monocyte;mouse model;Natural Killer Cells;neoplastic cell;novel;novel therapeutics;Oncogenic Viruses;oncolysis;Oncolytic;oncolytic herpes simplex virus;oncolytic virotherapy;Osteosarcoma;Pathway interactions;Patients;Pattern;Pattern recognition receptor;Pharmaceutical Preparations;Production;protein expression;Proteomics;Rationalization;receptor expression;Reporter Genes;Reporting;Research;response;Role;Sampling;Signal Transduction;single-cell RNA sequencing;success;synergism;Testing;Therapeutic;Time;TLR4 gene;TNFRSF10B gene;TNFSF10 gene;Transcript;Treatment Efficacy;tumor;Viral;Viral Proteins;Virus;Virus Diseases;Western Blotting;Work

PROJECT_TITLE: Mechanisms of Synergy between Oncolytic Herpes Simplex Virus and Trabectedin in Pediatric Bone Sarcomas


ADMINISTERING_IC: EB

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Digestive Diseases;Liver Disease;Regenerative Medicine;Transplantation

ORG_CITY: BOSTON

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

ORG_STATE: MA

PHR: Lay Summary The engineering of implantable tissues has the potential to address the shortage of organs available for transplantation; however, for solid organs like the liver, progress has been stymied by the lack of a robust blood supply to support key functional cells as well as the inability to harness the natural regenerative capacity of the liver to grow in the face of sudden injury. This project will develop new tools to control both the processes of blood vessel growth (vascularization) and tissue growth (expansion) by taking control over the cell-cell signaling processes that normally coordinate the process and potentially improve upon these natural processes. As such, these studies will address several major hurdles towards the engineering of tissues for treating diseases that are otherwise only cured by whole organ transplantation.

PI_NAMEs: BHATIA, SANGEETA N.;CHEN, CHRISTOPHER S (contact);KHALIL, AHMAD SAMIR

PROGRAM_OFFICER_NAME: FEHR, TUBA HALISE

PROJECT_TERMS: 3-Dimensional;Address;Biological Models;Biology;Blood capillaries;Blood Vessels;Buffers;Cell Communication;Cell Signaling Process;cell type;Cells;Clinical;Communities;Complex;density;Disease;dosage;efficacy testing;Endothelial Cells;Endothelium;Endowment;Engineering;Engraftment;Environment;Experimental Models;Fiber;Fibroblasts;fitness;Gene Expression;Generations;Goals;Growth;Hepatic;Hepatic Tissue;Hepatocyte;Human;Human Engineering;Implant;implantation;improved;In Vitro;in vitro Model;in vivo;in vivo Model;Injury;innovative technologies;insight;intercellular communication;Life;Liver;liver injury;Liver parenchyma;liver transplantation;Mediating;Microfluidics;Modeling;Mus;Natural regeneration;novel strategies;old mice;Organ;Organ Size;Organ Transplantation;Oxygen;paracrine;Paracrine Communication;Pattern;Perfusion;Physiological;Play;Process;regenerative;Regenerative capacity;Regenerative engineering;Regenerative Medicine;release factor;Research Personnel;response;Role;Signal Transduction;Solid;Stromal Cells;synthetic biology;System;Systems Integration;Technology;Therapeutic;Tissue Engineering;Tissue Grafts;Tissues;tool;transcription factor;Transplantation;Variant;Vascular blood supply;vascular tissue engineering;Vascularization

PROJECT_TITLE: Synthetic vascularization and regeneration in engineered tissues

STUDY_SECTION: CMT

STUDY_SECTION_NAME: Cellular and Molecular Technologies Study Section[CMT]


ED_INST_TYPE: HOSPITALS

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

ORG_CITY: HOUSTON

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: Project Narrative Our understanding of cancer at the level of molecules, cells and tissues has increased exponentially over the last three decades, while the number of clinician-investigators needed to translate this knowledge through hypothesis-driven clinical trials has actually decreased. If we are to accelerate the development of more effective, less toxic targeted therapy, immunotherapy, and personalized care, we must train and sustain the careers of exceptional and diverse young clinician-investigators who can develop long-term programs of clinical and translational research with strategically-chosen series of innovative clinical trials with relevant correlative studies. The MD Anderson Paul Calabresi K12 Program has the track record, deep commitment, mentors, patients, infrastructure and facilities to attract and to develop the careers of young clinician- investigators who will lead the clinical and translational development of oncology over the next decades.

PI_NAMEs: HONG, DAVID S.;KOPETZ, SCOTT  (contact);WESTIN, SHANNON NEVILLE

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: Academia;Acceleration;anti-cancer research;Applications Grants;Award;Cancer Biology;cancer care;cancer therapy;career;Clinic;Clinical;clinical infrastructure;Clinical Oncology;Clinical Research;Clinical Sciences;Clinical Trials;college;Contracts;Data;Development;Doctor of Philosophy;Environment;Evaluation;Faculty;faculty support;Funding;Goals;Grant;Health;Image;insight;Knowledge;Laboratories;Laboratory Research;Medicine;Mentored Clinical Scientist Development Program;Mentors;Minority Recruitment;novel;novel therapeutics;patient oriented;Patients;Peer Review;personalized medicine;programs;Publications;Research Personnel;symposium;Tissues;Training;Translational Research;translational therapeutics;Underrepresented Minority;University of Texas M D Anderson Cancer Center

PROJECT_TITLE: Paul Calabresi Clinical Oncology Award

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


ADMINISTERING_IC: NS

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Biomedical Imaging;Neurosciences

ORG_CITY: Princeton

ORG_NAME: PRINCETON UNIVERSITY

ORG_STATE: NJ

PHR: Narrative Important aspects of memory, such as those affected in Alzheimer’s disease, are believed to be enabled by specialized wiring patterns between neurons. However current technology cannot assess these wiring patterns. This project will develop a new method for assessing wiring patterns deep in the brain, and then use it to discover wiring patterns necessary for healthy memory function.

PI_NAMEs: RIORDAN, ALEXANDER  (contact)

PROGRAM_OFFICER_NAME: OSBORNE, LESLIE CAROL

PROJECT_TITLE: Circuit reconstruction of functionally-identified neurons in deep brain regions: application to grid cells


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Physical Injury - Accidents and Adverse Effects;Prevention

ORG_CITY: BALTIMORE

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: PROJECT NARRATIVE: Up to 86% of preventable deaths after trauma are related to sequelae of multicavitary hemorrhage in the non-compressible torso. Whole-body CT angiography (WBCTA) is routinely performed on trauma admission as a screening and surgical planning tool and is associated with a survival benefit, however interpretation delays and diagnostic error contribute to delays to transfusion and surgical or angiographic hemostatic intervention. High-trust human-centered computer-aided detection and diagnosis (CAD) tools for screening, hemorrhage burden quantification, and personalized decision support will accelerate and standardize image analysis of torso hemorrhage.

PI_NAMEs: DREIZIN, DAVID  (contact)

PROGRAM_OFFICER_NAME: CHAO, CHIEN-CHUNG

PROJECT_TERMS: Abdomen;Acceleration;Acidosis;Admission activity;Affect;Age;algorithm development;Algorithms;American;Angiography;Artificial Intelligence;Behavior;Big Data;Blood;Blood Coagulation Disorders;Blood Pressure;Body Regions;Body System;Cessation of life;Chest;Classification;classification algorithm;Clinical;clinical decision-making;clinically actionable;clinically relevant;cohort;Collaborations;computer aided detection;computer center;Computer-Assisted Diagnosis;Consumption;Data;Data Set;Databases;Decision Making;Decision Support Systems;Delphi Study;design;Detection;Development;Diagnosis;Diagnostic Errors;diagnostic tool;disorder risk;distraction;Early Intervention;Engineering;Ensure;Expert Opinion;Extravasation;Failure;Fatigue;Feedback;Future;Goals;Heart Rate;Hematoma;hemodynamics;Hemorrhage;Hemostatic Agents;Hemothorax;Hour;Human;human centered design;human-in-the-loop;Image;Image Analysis;image processing;improved;indexing;Injury;Intervention;Knowledge;Label;Laceration;large datasets;Life;Liquid substance;Measurement;Medical Imaging;Modality;Monitor;mortality;Multi-Institutional Clinical Trial;natural hypothermia;novel;Operative Surgical Procedures;Organ;organ injury;Outcome;Patient Triage;Patients;Pelvis;pelvis fracture;Performance;Peritoneal;personalized decision;personalized diagnostics;Physiological;Pleural;point of care;Population;Population Heterogeneity;predict clinical outcome;preference;Prevalence;prevent;preventable death;Process;Protocols documentation;Provider;Radiology Specialty;rapid detection;Reader;Reading;Recommendation;Reporting;Research;resilience;Resources;Rest;Resuscitation;Risk;Safety;Sampling;screening;Screening procedure;Severities;Shock;Software Design;Solid;Source;Speed;Standardization;System;Task Performances;Testing;Time;tool;Transfusion;Trauma;trauma care;trauma centers;Trust;United States;Validation;Visualization;Work

PROJECT_TITLE: Human-centered CT-based CADx Tools for Traumatic Torso Hemorrhage

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: PHILADELPHIA

ORG_NAME: PHILADELPHIA VA MEDICAL CENTER

ORG_STATE: PA

PHR: PROJECT NARRATIVE Despite the many associated health benefits, more than half of Veterans do not achieve enough regular physical activity. Our prior work has demonstrated that gamification, a method commonly used for health promotion, can lead to sustained increases in physical activity if it is designed using insights from behavioral economics to enhance social incentives. In this study, we will compare the effectiveness of behaviorally designed gamification that encourages Veterans to collaborate or compete on physical activity levels and examine clinical outcomes as well as costs, barriers and facilitators to implementation of the program within Veterans Affairs.

PI_NAMEs: GREYSEN, SCOTT RYAN;GREYSEN, SCOTT RYAN (contact);NAVATHE, AMOL S

PROJECT_TERMS: Address;adult obesity;arm;attentional control;Award;Behavioral;behavioral economics;Behavioral trial;Blood Pressure;cardiovascular disorder risk;Caring;Characteristics;Chronic;Clinical;Clinical Trials;cohort;Collaborations;compare effectiveness;connected care;Control Groups;cost;Cost Analysis;cost effectiveness;Cost Effectiveness Analysis;Counseling;Data;Decision Making;demographics;design;Development;Diabetes Mellitus;digital;digital health;disorder prevention;Effectiveness;effectiveness evaluation;Elements;Enrollment;ethnic minority;experience;Family;Family member;Feedback;follow-up;Future;General Population;Health;health application;Health behavior;Health Benefit;Health Promotion;Health Status;Health system;Heart;Heterogeneity;high risk;Human;Human Resources;Hypertension;implementation cost;implementation efforts;implementation facilitators;improved;Incentives;innovation;insight;Intervention;Interview;Investigation;Learning;machine learning method;Medical;Medical center;Mental Health;Methodology;Methods;Minority Groups;mobile computing;moderate-to-vigorous physical activity;Monitor;mortality;Obesity;Outcome;Overweight;participant interview;personalized approach;personalized intervention;Persons;Philadelphia;Physical activity;Pilot Projects;process evaluation;programs;Qualitative Evaluations;Quantitative Evaluations;racial minority;Randomized;randomized trial;randomized, clinical trials;Randomized, Controlled Trials;recruit;remote monitoring;Risk Reduction;Sampling;Sleep;social;Social Network;statistical and machine learning;Subgroup;Techniques;technology platform;Testing;therapy design;Translational Research;treatment effect;Underrepresented Minority;United States Department of Veterans Affairs;US State;Use Effectiveness;Veterans;Veterans Health Administration;Videoconferencing;Visit;wearable device;Weight;Wellness Program;Woman;Work;Workplace

PROJECT_TITLE: A Randomized Trial of Behaviorally Designed Gamification and Social Incentives to Increase Physical Activity Among Overweight and Obese Veterans

STUDY_SECTION_NAME: HSR-2 Behavioral, Social, and Cultural Determinants of Health and Care[HSR2]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics

ORG_CITY: CHICAGO

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: Project Narrative: Understanding the natural design of protein molecules is a route to learning fundamental principles and enabling practical engineering. Here, we propose to extend and apply a data-driven, evolution-based design process that enables a new strategy for problems in protein mechanism and evolution.

PI_NAMEs: RANGANATHAN, RAMA  (contact)

PROGRAM_OFFICER_NAME: CHO, THOMAS Y

PROJECT_TERMS: Address;Agriculture;Algorithms;Amino Acid Sequence;Amino Acids;Area;Bacillus subtilis;Base Sequence;Binding;Biochemical;Biological Assay;Biological Models;Biology;Catalysis;Characteristics;chemical reaction;Chemistry;Chorismate Mutase;chymotrypsin;combinatorial;computer framework;Data;Data Set;design;Development;Diagnostic;Directed Molecular Evolution;Energy harvesting;Engineering;Environment;Enzymes;Escherichia coli;Evolution;fitness;Foundations;Gene Duplication;Gene Mutation;gene synthesis;Genome;Geometry;Goals;Health;Homologous Gene;Human;In Vitro;in vivo;Individual;information model;Laboratories;Learning;Mathematics;Metabolic;Microfluidics;Modeling;molecular sequence database;Mutagenesis;Mutation;new technology;novel strategies;Orthologous Gene;Outcome;paralogous gene;Pathway interactions;Pattern;Physics;Process;programs;Property;protein aminoacid sequence;Protein Engineering;Protein Family;protein folding;protein structure;Proteins;rational design;Research;Route;Serine Protease;SH3 Domains;Shapes;Software Tools;Specificity;Statistical Models;Structure;Substrate Specificity;synthetic protein;System;Testing;Therapeutic;Time;Trypsin;Variant;Work;Yeasts

PROJECT_TITLE: Data-driven, evolution-based design of proteins

STUDY_SECTION: MSFD

STUDY_SECTION_NAME: Macromolecular Structure and Function D Study Section[MSFD]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Disability Research;Frontotemporal Dementia (FTD);Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE Gait and balance impairment are an important cause of disability and death in patients with progressive supranuclear palsy, but diagnostic tests and treatments are lacking. We aim to describe objectively quantifiable metrics of gait and balance impairment in progressive supranuclear palsy and determine the underlying mechanism using advanced neuroimaging. Knowledge gained from this work will improve our understanding of progressive supranuclear palsy, identify those who are at risk for falls, and evaluate treatments that could reduce death and disability from falls.

PI_NAMEs: ALI, FARWA  (contact)

PROGRAM_OFFICER_NAME: REZAIZADEH, KAVON PAUL

PROJECT_TERMS: 3-Dimensional;Accreditation;Address;Age;Calibration;career;career development;Cessation of life;Clinic;Clinical;clinical biomarkers;clinical examination;clinical heterogeneity;clinical outcome measures;clinical practice;Clinical Research;clinical training;Clinical Treatment;Clinical Trials;clinically significant;Collaborations;comparative;Controlled Environment;cost effective;Data;Detection;Development;Devices;Diagnosis;Diagnostic tests;diagnostic tool;Diffusion Magnetic Resonance Imaging;disability;Disease;equilibration disorder;Equilibrium;Evaluation;experience;fall risk;falls;Frequencies;Future;Gait;Gait abnormality;Goals;Grant;Heterogeneity;Human;human model;Image;Impairment;improved;innovation;Knowledge;Laboratories;Locomotion;Magnetic Resonance Imaging;Measures;Mentorship;Methods;Minnesota;Monitor;Morbidity - disease rate;mortality;Motion;motor control;Movement Disorders;multidisciplinary;multimodality;Nerve Degeneration;Neuroanatomy;neurobiological mechanism;Neurodegenerative Disorders;neuroimaging;normal aging;Outcome;Outcome Measure;Outcomes Research;patient oriented research;patient population;Patients;Pattern;Phenotype;portability;Positioning Attribute;Posture;Productivity;professor;prognostic assays;programs;Progressive Supranuclear Palsy;Qualifying;Reporting;Research;Research Methodology;Research Project Grants;Research Proposals;Severity of illness;sex as a biological variable;skills;Standardization;statistics;structural imaging;Syndrome;System;Tauopathies;Technology;Testing;three-dimensional modeling;tractography;Training;Translations;treatment trial;trial planning;Universities;Validation;wearable device;Work

PROJECT_TITLE: Mechanisms of Gait and Balance Impairment in Progressive Supranuclear Palsy

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-1 Study Section[NST-1]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Brain Disorders;Emerging Infectious Diseases;Infectious Diseases;Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases;Transmissible Spongiform Encephalopathy (TSE)

ORG_CITY: HANOVER

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: Project narrative Creutzfeldt-Jakob disease (CJD), Chronic Wasting Disease (CWD), bovine spongiform encephalopathy (BSE), and scrapie, are a group of infectious fatal brain diseases caused misfolded proteins known as prions. We propose to use a powerful new approach that leverages the power of next generation sequencing to identify all of the genes that regulate prion metabolism in cells. These studies will provide for the first time a complete and unbiased map of the molecular pathways used by living cells to make and destroy prions, and thereby advance our fundamental knowledge of prion cell biology and identify novel targets for drug therapy.

PI_NAMEs: SUPATTAPONE, SURACHAI  (contact)

PROGRAM_OFFICER_NAME: DALEY, WILLIAM PATRICK

PROJECT_TERMS: Anabolism;Atlases;Biochemical;Biochemical Pathway;Biological;Bovine Spongiform Encephalopathy;Brain;Brain Diseases;Brain region;Cell Line;Cells;Cellular biology;Chronic Wasting Disease;Clustered Regularly Interspaced Short Palindromic Repeats;cofactor;conformer;Creutzfeldt-Jakob Syndrome;experimental study;Fluorescence-Activated Cell Sorting;Genes;Genetic;Genetic Screening;Genomic approach;Genomic Library;Genomics;Human;Incubated;Individual;Induced Neurons;Induced pluripotent stem cell derived human neuron;Infection;Knock-out;Knowledge;Libraries;Maps;Metabolic;Metabolic Pathway;metabolic profile;Metabolism;Methods;misfolded protein;model organism;Modeling;Molecular;Molecular Conformation;Mus;Neurodegenerative Disorders;Neuronal Differentiation;Neurons;Neurotropism;new therapeutic target;next generation sequencing;novel;novel strategies;Pathway interactions;Pattern;Predisposition;Prion Diseases;Prions;PrP;PrPSc Proteins;Scrapie;Sorting;Surface;targeted treatment;Techniques;Testing;Time;trafficking;Undifferentiated;whole genome;Work

PROJECT_TITLE: Mapping Molecular Pathways that Control Prion Metabolism


NIH_SPENDING_CATS: Cancer;Clinical Research;Immunotherapy;Lung;Lung Cancer;Precision Medicine;Prevention

ORG_CITY: AMHERST

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

ORG_STATE: NY

PHR: PROJECT NARRATIVE Current screening and diagnostic tests for lung cancer such as low dose CT and tissue biopsy are limited by high false positive rate, radiation exposure and invasive procedure. Liquid biopsy detects tumor-derived biomarkers in blood, allows sequential sampling, complements medical imaging and risk factor data, and thus represents a new and non-invasive strategy to address these challenges. We propose to develop an accurate, simple, fast, user-friendly and cost-effective liquid biopsy test, i.e., the Exo-PROS assay, to sensitively and simultaneously detect multiple types of biomarkers in tumor-derived exosomes for lung cancer early detection and immunotherapy response prediction and monitoring.

PI_NAMEs: DY, GRACE ;ITO, FUMITO ;WU, YUN  (contact)

PROGRAM_OFFICER_NAME: PATRIOTIS, CHRISTOS F

PROJECT_TERMS: Address;anti-PD1 therapy;Antigens;Area Under Curve;Biological Assay;Biological Markers;Biopsy;Biosensing Techniques;Biosensor;Blood;Body Fluids;cancer biomarkers;Cancer Etiology;Cancer Patient;Carbohydrates;Cell Communication;Cell secretion;Cells;Cessation of life;checkpoint therapy;Clinical;clinical decision-making;cohort;Complement;Consumption;cost effective;Data;Development;Diagnostic;diagnostic accuracy;Diagnostic Sensitivity;Diagnostic tests;diagnostic value;Disease;Early Diagnosis;Early treatment;effective therapy;Enzyme-Linked Immunosorbent Assay;Epidermal Growth Factor Receptor;exosome;extracellular vesicles;high risk;Image;imaging modality;Immune checkpoint inhibitor;Immunotherapy;improved;In Situ;liquid biopsy;low dose computed tomography;lung cancer screening;Malignant neoplasm of lung;Malignant Neoplasms;Measurement;Medical Imaging;Methods;MicroRNAs;Minority;Monitor;mortality;nanosized;Non-Small-Cell Lung Carcinoma;Normal Cell;overexpression;Patient Care;Patient Selection;Patient-Focused Outcomes;Patients;pembrolizumab;Performance;Pilot Projects;Portraits;predicting response;Prediction of Response to Therapy;predictive marker;Predictive Value;Procedures;programmed cell death ligand 1;Proteins;Quantitative Reverse Transcriptase PCR;Radiation exposure;recruit;responders and non-responders;response;Risk Factors;RNA;Sampling;screening;screening guidelines;Sensitivity and Specificity;sensor;Serum;small cell lung carcinoma;Specificity;standard of care;Survival Rate;Technology;Testing;Time;Tissues;Tumor Markers;Tumor-Derived;user-friendly

PROJECT_TITLE: Lung Cancer Early Detection and Immunotherapy Response Prediction and Monitoring with an Exo-PROS Liquid Biopsy Assay

STUDY_SECTION: CBSS

STUDY_SECTION_NAME: Cancer Biomarkers Study Section[CBSS]


ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PUBLIC HEALTH RELEVANCE CXCR3 plays a central role in inflammation and has established clinical relevance in diseases such as atherosclerosis, cancer and inflammatory bowel disease. We propose an innovative approach to study CXCR3 signaling to aid in the development of novel drugs. Thus, the proposed research is relevant to the part of NIH’s mission to foster fundamental creative discoveries, innovative research strategies, and their applications as a basis for ultimately protecting and improving health.

PI_NAMEs: RAJAGOPAL, SUDARSHAN K (contact)

PROGRAM_OFFICER_NAME: LEWIS, MECHELLE MAYLEBEN

PROJECT_TERMS: Adaptor Signaling Protein;Address;Agonist;Allosteric Regulation;antagonist;Atherosclerosis;beta-arrestin;Biological;cell motility;Cell Physiology;chemokine;chemokine receptor;Chemotaxis;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;Contact hypersensitivity;Creativeness;CXC chemokine receptor 3;CXCL9 gene;CXCR3 gene;Development;Disease;Drug Design;drug development;Drug Modelings;Drug Targeting;Endocytosis;Endosomes;FDA approved;Fostering;G-Protein-Coupled Receptors;Genetic Transcription;Goals;GTP-Binding Proteins;Health;Heterotrimeric GTP-Binding Proteins;Immediate-Early Genes;Immune;improved;In Vitro;in vivo;Inflammation;Inflammatory;Inflammatory Bowel Diseases;inflammatory modulation;Inflammatory Response;innovation;knock-down;Knowledge;Ligands;Location;Malignant Neoplasms;Mediating;Mission;Mitogen-Activated Protein Kinases;Modeling;Molecular Conformation;mouse model;mutant;Mutant Strains Mice;new therapeutic target;novel drug class;novel therapeutics;Output;Pattern;Pertussis Toxin;Phosphorylation;Play;prevent;public health relevance;receptor;Receptor Inhibition;receptor internalization;recruit;Regulation;Research;response;Role;Serum Response Element;Signal Pathway;Signal Transduction;skin disorder;small molecule;System;T cell regulation;T-Lymphocyte;targeted treatment;Testing;Therapeutic;United States National Institutes of Health;Work

PROJECT_TITLE: Biasing CXCR3 Signaling to Modulate the Inflammatory Response

STUDY_SECTION: MIST

STUDY_SECTION_NAME: Molecular and Integrative Signal Transduction Study Section[MIST]


NIH_SPENDING_CATS: Cancer;Childhood Leukemia;Genetics;Hematology;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: CORAL GABLES

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: Project Narrative We recently demonstrated that CARM1 functions as an oncogene in AML, a very aggressive cancer with limited therapeutic options and a poor survival rate. The proposed studies represent a conceptual shift from targeting specific mutations found in subsets of cancer patients, to targeting the chromatin modifiers and transcriptional regulators that are essential for cancer cell growth. They will help establish the importance of CARM1 in the pathogenesis of AML, and advance our understanding of how CARM1 inhibitors could become a novel and effective “epigenetic-targeted” cancer therapy.

PI_NAMEs: NIMER, STEPHEN D. (contact)

PROGRAM_OFFICER_NAME: KLAUZINSKA, MALGORZATA

PROJECT_TERMS: Acute Myelocytic Leukemia;acute myeloid leukemia cell;Affect;AML1-ETO fusion protein;Arginine;Blood Cells;cancer cell;Cancer Cell Growth;Cancer Patient;cancer type;Cell Death;Cell Differentiation process;cell growth;Cell Line;Cell Survival;cell type;Cells;ChIP-seq;Chromatin Remodeling Factor;Co-Immunoprecipitations;coactivator-associated arginine methyltransferase 1;Combined Modality Therapy;Cytoplasm;Dependence;Development;Disease;effective therapy;Engraftment;Enzymes;Epigenetic Process;experimental study;Genes;Genetic;Genetic Transcription;Goals;Hematopoietic;Hematopoietic stem cells;Histones;Human;Human Cell Line;improved;inhibitor;insight;JAK2 gene;knock-down;Knock-out;leukemia;Malignant Neoplasms;Mass Spectrum Analysis;Messenger RNA;metaplastic cell transformation;Methylation;Modeling;Modification;Molecular;mouse model;Mutation;Myelogenous;NOD/SCID mouse;non-histone protein;novel;Nuclear;Oncogenes;Oncogenic;Pathogenesis;Pathway interactions;Patients;Phosphorylation;posttranscriptional;Pre-Clinical Model;Predisposition;Proliferating;protein protein interaction;Protein-Arginine N-Methyltransferase;Proteins;Regulation;resistance mechanism;Role;RUNX1 gene;Sampling;Signal Transduction;small molecule inhibitor;Specificity;Survival Rate;System;targeted cancer therapy;targeted treatment;Techniques;Testing;Therapeutic;therapeutically effective;therapy development;Toxic effect;transcription factor;transcriptome sequencing;Tyrosine;Up-Regulation

PROJECT_TITLE: Dependency of AML on CARM1 activity

STUDY_SECTION: MCH

STUDY_SECTION_NAME: Molecular and Cellular Hematology Study Section[MCH]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Brain Disorders;Dementia;Eye Disease and Disorders of Vision;Neurodegenerative

ORG_CITY: IRVINE

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

ORG_STATE: CA

PHR: This research addresses a basic phenomenon - protein association and aggregation - that underlies diseases such as Alzheimer's, cataract, and type II diabetes that are increasingly prevalent in our aging population, as well as food safety concerns related to prion disease. By greatly increasing the speed with which we can model aggregation, we can gain new insights into its mechanisms and possible inhibition.

PI_NAMEs: BUTTS, CARTER TRIBLEY (contact)

PROGRAM_OFFICER_NAME: NGUYEN, HAN

PROJECT_TERMS: Address;aging population;Alzheimer's Disease;amyloid fibril formation;Amyloid Fibrils;Biological;Biological Process;biophysical chemistry;biophysical techniques;Biophysics;Calibration;Cataract;Collaborations;Collection;Complex;Coupling;Crystalline Lens;Crystallins;Data;Development;Disease;Etiology;experimental study;Food Safety;Heat shock proteins;Hour;Individual;innovation;insight;Mathematics;Medical;Methods;model development;Modeling;Molecular Chaperones;National Institute of General Medical Sciences;network models;Non-Insulin-Dependent Diabetes Mellitus;novel;Pathway Analysis;Pathway interactions;Prion Diseases;protein aggregation;protein function;protein oligomer;protein structure;Proteins;Research;Scientist;social;Social Network;Social Sciences;Speed;statistics;Structure;System;Techniques;Tertiary Protein Structure;Testing;Time;Work;α-Crystallins

PROJECT_TITLE: DMS/NIGMS 2: Statistical Network Models for Protein Aggregation


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Genetics;Human Genome;Pediatric;Rare Diseases

ORG_CITY: LA JOLLA

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE Errors in cell duplication produce an abnormal chromosome number, called aneuploidy, and such errors have long been linked to human tumors. A striking chromosomal abnormality linked to chromosome missegregation is chromothripsis, an event in which one (or two) chromosomes appear to have been shattered into tens to hundreds of small genomic fragments and religated back together in random order. We now propose to determine mechanisms of fragmentation of a chromosome during chromothripsis, determine how shattered chromosomes are reassembled into reorganized chromosomes and extrachromosomal DNA, and determine mechanisms of inheritance of extrachromosomal DNA.

PI_NAMEs: CLEVELAND, DON W (contact)

PROJECT_TERMS: Aneuploidy;Antisense Oligonucleotide Therapy;ATP phosphohydrolase;Back;Cells;Centromere;Chromosome abnormality;chromosome missegregation;chromosome number abnormality;Chromosome Segregation;Chromosome Structures;Chromosomes;chromothripsis;Complex;Cyclins;Cytokinesis;Development;DNA biosynthesis;Epigenetic Process;Event;extrachromosomal DNA;Extrachromosomal Inheritance;Frequencies;Genome;genome sequencing;Genomics;Glioblastoma;Grant;Haploidy;Human;Immune checkpoint inhibitor;Ligation;Link;Malignant neoplasm of brain;Malignant Neoplasms;Mammals;Mediating;micronucleus;Mitotic;Mitotic Checkpoint;Molecular;Molecular Conformation;National Institute of General Medical Sciences;Nervous System Disorder;Nuclear;nuclease;prevent;Role;Testing;therapy development;tumor;tumorigenesis;ubiquitin-protein ligase;whole genome;Y Chromosome

PROJECT_TITLE: Mechanisms of chromosome segregation, aneuploidy, and tumorigenesis


ORG_CITY: ITHACA

ORG_DEPT: CHEMISTRY

ORG_NAME: CORNELL UNIVERSITY

PHR: Narrative The intrinsic motions of proteins give life to their functions and enable exquisite control of their activities. However, visualizing molecular motion is extremely challenging. X-ray methods and cryo-electron microscopy will be inte- grated in new ways to bear on this problem.

PI_NAMEs: ANDO, NOZOMI  (contact)

PROGRAM_OFFICER_NAME: FLICKER, PAULA F

PROJECT_TITLE: Protein Allostery and Catalysis Beyond Bragg Diffraction

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Asthma;Bioengineering;Clinical Research;Lung;Networking and Information Technology R&D (NITRD);Pediatric;Prevention

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: PROJECT NARRATIVE The proposed research is to develop and test a wearable, wirelessly communicating, always-on, acoustic- coupler-free stethoscope for detection of poorly controlled asthma symptoms in children.

PI_NAMEs: KIM, EUN SOK (contact)

PROGRAM_OFFICER_NAME: SHENOY, SIDDHARTH KAUP

PROJECT_TERMS: accurate diagnosis;Acoustics;Adolescent;Age;age group;Air Movements;airway obstruction;algorithm development;Algorithms;Allergens;Ambulatory Monitoring;Asthma;asthma exacerbation;asthmatic;asthmatic patient;automated segmentation;battery recharging;Behavioral;Breathing;Caregivers;Cellular Phone;Cessation of life;Characteristics;Charge;Chest;Child;Child health care;Childhood Asthma;Classification;classification algorithm;Clinical;Clinical Management;clinically relevant;Consensus;Coughing;Detection;Development;Device Designs;Device or Instrument Development;Devices;Diagnosis;diagnostic accuracy;diagnostic criteria;diagnostic value;Ear;Early Diagnosis;Electronics;Elements;Emergency Situation;Event;Exercise;Exhalation;Exposure to;Failure;Family member;Frequencies;Goals;Guidelines;Home;Hospitalization;Human;improved;Individual;Infant;Inhalation;Intellectual functioning disability;Internet;Lung;Measurable;Measures;Medical;member;Microfabrication;microphone;Monitor;Morbidity - disease rate;Nature;Notification;novel;Outcome;Parents;Patients;Pattern;Pattern Recognition;pediatric patients;performance tests;Physiological;Physiology;Population;portability;power consumption;pressure;Process;prototype;Provider;pulmonary function;Pulmonary function tests;Recording of previous events;Reporting;Research;Respiratory Diaphragm;Respiratory Function Tests;Respiratory Signs and Symptoms;Respiratory Sounds;response;Self Management;signal processing;Signs and Symptoms;Sleep;sound;sound frequency;Stethoscopes;Symptoms;Testing;Time;tool;United States;United States National Institutes of Health;verbal;Visit;wearable device;Wheezing;wireless;wireless communication;wireless transmission

PROJECT_TITLE: Wearable, Always-on Stethoscope for Early Detection of Asthma Attack

STUDY_SECTION: ISD

STUDY_SECTION_NAME: Instrumentation and Systems Development Study Section[ISD]


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome;Infectious Diseases;Vector-Borne Diseases

ORG_CITY: SAN ANTONIO

ORG_NAME: TEXAS BIOMEDICAL RESEARCH INSTITUTE

PHR: Hybridization is thought to occur between schistosomes infecting humans (S. haematobium) and schistosomes infecting lifestock (S. bovis), but the frequency of hybridization and extent of gene transfer between species is unclear. This application will use genome sequencing of field collected schistosomes to determine the frequency and consequences of hybridization in natural populations. In addition we will use experimental crosses to determine how hybridization impacts biomedically important parasite traits. Finally we will critically examine the role that rodent host may play in hybridization.

PI_NAMEs: ANDERSON, TIM J (contact)

PROGRAM_OFFICER_NAME: JOY, DEIRDRE A

PROJECT_TITLE: Genomic consequences of schistosome hybridization

STUDY_SECTION: GVE

STUDY_SECTION_NAME: Genetic Variation and Evolution Study Section[GVE]


ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE A large group of human ciliopathies, such as chronic respiratory infections, laterality abnormalities, and infertility, are associated with motile cilia dysfunction. In this proposal, we will elucidate the architectural principles governing the ciliary assembly using Chlamydomonas mutants lacking the microtubule inner proteins (MIPs) that we have recently identified using high-resolution cryo-electron microscopy (cryo-EM). Most of the ciliary proteins we plan to study have orthologs in human cilia; therefore, our work will provide a molecular basis for understanding the etiology of a variety of many human ciliopathies.

PI_NAMEs: ZHANG, RUI  (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TERMS: Architecture;base;Basic Science;Beak;Binding;Biological Process;C-terminal;cell motility;Cell Physiology;Charge;Chlamydomonas;Chronic;Cilia;ciliopathy;cilium biogenesis;cilium motility;Complex;Cryoelectron Microscopy;Data;Dependence;Etiology;Eukaryota;Eukaryotic Cell;Filament;Flagella;fluid flow;Functional disorder;Genetic;Hair;Handedness;Hearing;Human;human disease;Impairment;in vitro Assay;in vivo;Individual;Infertility;Length;Location;Microtubule-Associated Proteins;Microtubules;Molecular;Motility;mutant;nanomachine;Organelles;Organism;Orthologous Gene;particle;Perception;Periodicity;Positioning Attribute;protein complex;Proteins;Radial;Registries;Research;research study;Resolution;Respiratory Tract Infections;Running;scaffold;Sensory;Shapes;Site;Smell Perception;Structure;Surface;Tail;tektins;Testing;Tubulin;Vision;Work

PROJECT_TITLE: Structural and functional studies of axonemal microtubule inner proteins (MIPs)

STUDY_SECTION: NCSD

STUDY_SECTION_NAME: Nuclear and Cytoplasmic Structure/Function and Dynamics Study Section[NCSD]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Lewy Body Dementia;Neurodegenerative;Neurosciences;Parkinson's Disease;Prevention

ORG_CITY: CLEVELAND

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

PHR: Project Narrative The Lewy body dementias are the second most common cause of dementia in the elderly. Diagnosis can be difficult and determinants of clinical symptoms and progression are unclear. This renewal proposal will expand the current Dementia with Lewy Bodies Consortium (DLBC) participant numbers and utilize the deep phenotyping and biomarker characterization to improve upon diagnosis, prediction of progression, and clinical variability.

PI_NAMEs: GALASKO, DOUGLAS R;LEVERENZ, JAMES BRUCE (contact);LOPEZ, OSCAR L.

PROGRAM_OFFICER_NAME: BABCOCK, DEBRA J

PROJECT_TERMS: Address;Agreement;alpha synuclein;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer’s disease biomarker;Amyloid;Autopsy;Behavioral;Biological;Biological Markers;Biology;biomarker development;biomarker discovery;biomarker panel;biomarker validation;Blood;candidate marker;Cerebrospinal Fluid;Characteristics;Clinical;Clinical assessments;clinical diagnosis;clinical phenotype;Cognition;Cognitive;cohort;Collection;cooperative study;COVID-19 pandemic;Data;Databases;Dementia;Dementia with Lewy Bodies;Detection;Development;Diagnosis;diagnostic biomarker;diagnostic value;Disease;dopamine system;Elderly;Enrollment;Failure;follow-up;Funding;Glial Fibrillary Acidic Protein;Image;imaging biomarker;imaging system;Impaired cognition;improved;Inflammation;Inflammatory Response;Infrastructure;Legal patent;Lewy Body Dementia;Lewy body pathology;Link;Measures;Modeling;Monitor;Motor;National Institute of Neurological Disorders and Stroke;National Institute on Aging;Natural History;Nerve Degeneration;neuroimaging;novel marker;Parkinson Disease;Parkinson's Dementia;Participant;Pathologic;Pathology;Patients;Persons;Phenotype;Plasma;Positioning Attribute;Principal Investigator;Prognosis;prognosis biomarker;prognostic model;prognostic value;programs;progression marker;Protocols documentation;Reaction;Research;Research Personnel;Sampling;Sleep disturbances;Standardization;Symptoms;Synapses;synuclein;tau Proteins;Techniques;United States

PROJECT_TITLE: Dementia with Lewy Bodies Consortium


NIH_SPENDING_CATS: Natural Products

ORG_CITY: Chicago

ORG_NAME: NORTHWESTERN UNIVERSITY

PHR: Project Narrative The broad goal of this research program is the continued successful development and application of cooperative catalysis concepts for asymmetric synthesis to move the fields of chemistry and biology forward by providing unconventional strategies and address key challenges involving catalysis compatibility, selectivity and novelty. We are specifically investigating innovative carbene catalyzed processes with different catalysis modes, carbocation driven processes, and merging photocatalysis with biocatalysis. New chemical method development integrated with target synthesis is an essential activity to access high value molecules that drive new chemical probe creation and potential therapeutics that are critical for new knowledge and medical advances.

PI_NAMEs: SCHEIDT, KARL A (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TITLE: New Cooperative Catalysis Concepts for Asymmetric Synthesis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-B(55)R]


ORG_CITY: STILLWATER

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: OKLAHOMA STATE UNIVERSITY STILLWATER

ORG_STATE: OK

PHR: NARRATIVE Bacteria can survive a wide range of environmental insults—including exposure to drugs, disinfectants and immune responses—due to dedicated systems that detect stresses and quickly activate internal defense mechanisms. A deeper understanding of bacterial stress responses will abet efforts to control unwanted microbial growth. The objectives of this proposal are to define fundamental principles governing how bacteria sense the presence of environmental stress, process sensory data to enact different dynamic response patterns, and use such response patterns to maximize cell fitness and survival under adverse conditions.

PI_NAMEs: CABEEN, MATTHEW T (contact)

PROGRAM_OFFICER_NAME: BLATCH, SYDELLA ANNE

PROJECT_TERMS: American;Antibiotics;antimicrobial;Bacillus subtilis;Bacteria;bacterial genetics;biological adaptation to stress;biological systems;Cell Lineage;Cells;Cytoplasm;Data;Dedications;Defense Mechanisms;detection platform;Disinfectants;drug resistant bacteria;Environment;Exposure to;fitness;Fluorescence Microscopy;Growth;Health;Human;Immune response;Individual;Infection;Knowledge;microbial;microfluidic technology;Modeling;Molecular;pathogenic bacteria;Pattern;Pharmaceutical Preparations;Predisposition;Process;Proteins;response;sensor;sensory input;Sensory Process;Specific qualifier value;Stress;stressor;System;Techniques;Time;treatment strategy

PROJECT_TITLE: Stress sensing and processing by bacterial cytoplasmic megacomplexes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-D(55)R]


ORG_CITY: Nashville

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: Narrative: Dr. Joshua Bauer's cancer-related projects within the Vanderbilt High-Throughput Screening (HTS) Facility are focused on three areas: 1) compound library screening and other HTS drug screening, 2) functional genomics (siRNA/CRISPR) library screening, and 3) high-content screening (HCS) and analysis. His integral role and success stems from his ability to collaborate, design and perform screens, and intellectually contribute to projects, grant proposals, and manuscripts. The blend of his skills, expertise, and knowledge provide a unique, indispensable role within the Vanderbilt cancer research program to mend cancer research, chemical biology, genomics, drug discovery, and translational drug investigation.

PI_NAMEs: BAUER, JOSHUA A. (contact)

PROGRAM_OFFICER_NAME: SHARMAN, ANU

PROJECT_TERMS: 3-Dimensional;anti-cancer research;Applications Grants;Area;Award;Biochemistry;Biological Assay;Biology;Cancer Biology;cancer cell;Cancer Center;Cancer Research Project;career development;Chemicals;Clinical Trials Design;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Comprehensive Cancer Center;Computer software;Core Facility;design;Development;drug discovery;Drug Screening;Educational workshop;Exposure to;functional genomics;Funding;Genetic;Genomic approach;Genomics;Goals;graduate student;high throughput screening;high-throughput drug screening;Image;innovation;instrumentation;Investigation;Knowledge;Lead;Libraries;Malignant Neoplasms;Manuscripts;meetings;member;Modeling;Molecular;Molecular Probes;new therapeutic target;novel;Organoids;Paper;Pharmaceutical Preparations;pharmacologic;Pharmacology;Play;Postdoctoral Fellow;programs;Research;Research Personnel;Role;Scientist;screening;Services;skills;Small Interfering RNA;stem;success;symposium;Technology;Therapeutic;Training;Work

PROJECT_TITLE: Cancer Pharmacologist and HTS Scientist


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

ORG_CITY: BOSTON

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: PROJECT NARRATIVE Unhealthy drinking can exacerbate two highly prevalent HIV-related comorbidities/co-occurring conditions, chronic pain and physical inactivity, which in turn, can intensify alcohol use and affect physical and mental function in people living with HIV (PLWH). In this Program Project, we will conduct state-of-the-art e-health clinical trials research on scalable approaches to address the HIV-associated conditions chronic pain and physical inactivity in PLWH with unhealthy alcohol use. We will also support secondary analyses of the existing Boston ARCH cohort of PLWH with unhealthy drinking, and provide support and mentoring to trainees and investigators accessing the cohort data.

PI_NAMEs: STEIN, MICHAEL D (contact)

PROGRAM_OFFICER_NAME: ROACH, DEIDRA

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;addiction;Address;Affect;alcohol and other drug;Alcohol consumption;alcohol misuse;Alcohol or Other Drugs use;alcohol research;alcohol use disorder;Alcohols;antiretroviral therapy;Behavioral;Biometry;Boston;Cardiovascular Diseases;Caring;chronic pain;chronic painful condition;Clinical Trials;cohort;Collaborations;Communities;community setting;comorbidity;Complex;Data;Data Analyses;data management;Disease;drinking;Drug usage;Ecological momentary assessment;Ecology;efficacy testing;eHealth;Enrollment;exercise intervention;extend lifespan;falls;frailty;functional status;Funding;Goals;Grant;Health;Health behavior;Heavy Drinking;HIV;HIV Infections;HIV/AIDS;Home;improved;Infection;Infrastructure;interdisciplinary approach;Interdisciplinary Study;interest;Intervention;Investigation;Lead;Life;Life Style;Measurement;Mediator;Medical;Medicine;mental function;Mentors;Methodology;multidisciplinary;National Institute on Alcohol Abuse and Alcoholism;older adult;Osteopenia;Outcome;Pain;pandemic disease;Participant;Patients;Persons;Pharmaceutical Preparations;Physical activity;Physical Function;physical inactivity;Play;Population;population based;Procedures;Productivity;programs;prospective;Psychology;Public Health;randomized trial;Randomized, Controlled Trials;recruit;Research;Research Methodology;Research Personnel;Research Project Grants;Risk;Role;secondary analysis;secondary outcome;Services;substance use;Sum;Testing;Translating;trial design;United States National Institutes of Health;Visit;Work

PROJECT_TITLE: Boston Alcohol Research Collaboration  on HIV/AIDS - Comorbidity Center (Boston ARCH CC)


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Clinical Research;Clinical Trials and Supportive Activities;Eye Disease and Disorders of Vision;Macular Degeneration;Neurodegenerative;Neurosciences;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_CITY: Albany

ORG_NAME: REGENERATIVE RESEARCH FOUNDATION

PHR: Narrative Age-related Macular degeneration (AMD) is a common condition and major cause of blindness in the elderly. Early in AMD progression, the retinal pigment epithelial (RPE) cells that support the retina are lost and this continues until the retina no longer functions at which time vision is lost. We discovered an adult stem cell present in the RPE (RPESC) and found that transplantation of RPESC rescues vision in an animal model of AMD. The RPESC uniquely allows transplantation of RPE progenitor cells found to be more effective at preserving vision than fully developed RPE. We plan to carry out a sound clinical trial to translate these encouraging preclinical findings into therapy for AMD patients.

PI_NAMEs: STERN, JEFFREY H (contact)

PROGRAM_OFFICER_NAME: EVERETT, DONALD F

PROJECT_TERMS: Adult;adult stem cell;Age related macular degeneration;aging population;Amendment;Animal Model;Atrophic;Blindness;Caring;catalyst;Cell Differentiation process;Cells;Clinic;Clinical;Clinical Research;clinical research site;Clinical Trials;Collaborations;Collection;college;Communication;Conduct Clinical Trials;Consent;Consent Forms;Cyclic GMP;Data;Data Collection;data management;design;early phase clinical trial;effective therapy;Elderly;Engraftment;Enrollment;Ensure;epithelial stem cell;experience;experimental study;Eye;eye center;Genotype;Grant;Growth;improved;Institutional Review Boards;Intervention;Maintenance;Manuals;manufacture;Manuscripts;Measures;Medical;Michigan;Modeling;Modification;Monitor;Nature;nerve stem cell;Nonexudative age-related macular degeneration;novel therapeutics;operation;Outcome;Outcome Assessment;Pamphlets;Participant;Pathogenesis;Patient Recruitments;Patients;Phase;Phenotype;Pluripotent Stem Cells;post intervention;pre-clinical;preservation;Procedures;progenitor;programs;Protocols documentation;Qualifying;quality assurance;Rattus;recruit;Regenerative Medicine;repaired;Replacement Therapy;Reporting;Research Personnel;Retina;retina transplantation;Review Committee;Risk;Safety;Site;sound;Source;Specialist;stem cell biology;stem cell differentiation;Stem Cell Research;Stem cell transplant;stem cells;Structure of retinal pigment epithelium;Supporting Cell;Surgeon;Time;Tissues;transcriptome;transcriptomics;Translating;Translations;Transplantation;trial design;trial planning;tumor;tumor growth;United States National Institutes of Health;Universities;Vision;Work

PROJECT_TITLE: Phase1/2a Clinical Trial of RPESC-derived RPE Transplantation as Therapy for Non-exudative Age-related Macular Degeneration

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Chronic Pain;HIV/AIDS;Infectious Diseases;Pain Research;Substance Misuse

PI_NAMEs: SAITZ, RICHARD  (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Affect;Alcohol consumption;alcohol misuse;alcohol research;Alcohols;antiretroviral therapy;Attention;Biological Markers;Biometry;Boston;Cardiovascular Diseases;career;Caring;chronic pain;clinical trial implementation;clinical trial recruitment;Clinical Trials;cohort;Collaborations;Communication;Communities;comorbidity;Complex;Data;Data Analyses;data management;data sharing;digital;Disabling;drinking;Ecological momentary assessment;Ecology;eHealth;Elements;Enrollment;Environment;extend lifespan;Funding;Goals;Health;HIV;HIV/AIDS;Individual;Infection;innovation;interest;Lead;Leadership;Life;Medical;member;mental function;Mental Health;Mentors;Mission;Monitor;National Institute on Alcohol Abuse and Alcoholism;new pandemic;novel;operation;Pain;pandemic disease;Participant;Persons;Physical activity;physical conditioning;Physical Function;physical inactivity;Play;Population;post-pandemic;Procedures;programs;prospective;Public Health;Publications;randomized trial;randomized, clinical trials;recruit;Research;Research Personnel;Research Project Grants;Research Support;Resources;Risk;Role;Russia;Safety;Science;secondary analysis;social;Testing;Training;Translational Research;Uganda;United States National Institutes of Health;Visit;Work

PROJECT_TITLE: Administrative Core


ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: This short-term internship program at the University of Colorado Anschutz Medical Campus, locally known as GEMS (Graduate Experiences for Multicultural Students) seeks to expose undergraduate and health professional students from backgrounds under-represented in research to summer laboratory or clinical translational experiences in order to increase their representation in research related to cardiovascular, pulmonary or hematologic areas. The goal is to create a workforce of health-related researchers who are as diverse as the community they serve. By exposing these students early in their careers, we hope to capture their interest and excite them about the possibilities of biomedical research.

PI_NAMEs: FLORES, SONIA CASTRO (contact);TENNIS, MEREDITH A

PROJECT_TERMS: Address;Adopted;Area;Award;Behavioral Research;Biology;Biomedical Research;Capital;Cardiovascular Diseases;Cardiovascular system;career;Career Choice;Clinical Research;clinical translation;Cognitive Science;Colorado;Communities;Community of Practice;Complement;Country;Critical Care;cultural competence;Development;Diverse Workforce;diversity and inclusion;Doctor of Philosophy;Education Projects;education research;Educational workshop;Enrollment;Ensure;Environment;ethnic minority;Evaluation;experience;Exposure to;Face;Faculty;Failure;Feedback;Feeling;Funding;Goals;Grant;hands on research;Health;Health Personnel;Health Professional;Healthcare;Hematology;implicit bias;Individual;Infrastructure;Institution;Instruction;interest;Internships;Laboratories;Lead;Leadership;Literature;Lung;Lung Diseases;Manuscripts;marginalized population;Measures;Medical;Medicine;member;Mentors;Minority;Modeling;National Heart, Lung, and Blood Institute;novel;Participant;Population;Positioning Attribute;Postbaccalaureate;pressure;professional students;programs;Publishing;Pulmonology;Research;Research Activity;Research Personnel;Rest;Schools;Science;social;Social Sciences;Student Selections;student training;Students;success;summer internship;systemic barrier;Talents;theories;Time;Training;undergraduate student;Underrepresented Minority;Underrepresented Populations;Underrepresented Students;United States National Institutes of Health;Universities;Wisconsin;Work

PROJECT_TITLE: GEMS, a Short-Term Summer Internship Program for Diverse Students


NIH_SPENDING_CATS: Cardiovascular;Genetics;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Wound Healing and Care

PHR: Narrative: PAD affects more than 10 million people in the United States, and it continues to be a major cause of human morbidity and mortality associated with associated with cardiovascular diseases. Critical limb ischemia (CLI) is a serious condition in which peripheral artery disease (PAD) leads to irreversible limb muscle damage. About 40% of CLI patients undergo limb amputation one year after diagnosis, and 50% die after five years. Our previous work showed that muscle regeneration plays a critical role in determining the progression of PAD into a tissue loss phenotype of CLI, and in the present study, we will identify the critical changes of chromatin structure and function controlling muscle regeneration so that in the future we can develop innovative gene regulation therapy for limb salvage.

PI_NAMEs: DIAO, YARUI  (contact)

PROGRAM_OFFICER_NAME: POSTOW, LISA

PROJECT_TERMS: 3-Dimensional;Affect;Age;Architecture;ATAC-seq;Automobile Driving;Bioinformatics;Biological Assay;Blood flow;Cardiovascular Diseases;Cell Separation;Chromatin;Chromatin Loop;Chromatin Structure;critical limb Ischemia;Data;Data Set;Defect;Development;Diagnosis;differentiation in vitro;Disease Progression;Enhancers;Etiology;Failure;Foundations;Future;Gene Expression;Gene Expression Regulation;Genes;Genetic Transcription;Genome;Hi-C;Human;human morbidity;human mortality;improved;In Vitro;Individual;innovation;Ischemia;Isolated limb perfusion;limb amputation;Limb Salvage;Limb structure;Muscle;muscle progenitor cell;muscle regeneration;muscle repair;Muscle satellite cell;Natural regeneration;novel;Patients;Peripheral arterial disease;Persons;Phenotype;Play;prevent;Process;programs;Proliferating;promoter;regenerative;regenerative therapy;regenerative tissue;regenerative treatment;repaired;Research;Role;sex;Skeletal Muscle;stem cell self renewal;Structure;Testing;Tissues;transcriptome sequencing;treatment strategy;United States;Work

PROJECT_TITLE: The 4D nucleome of muscle regeneration in ischemia-induced tissue damage and repair

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-S(71)R]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Infectious Diseases;Pain Research;Physical Activity;Prevention;Substance Misuse;Telehealth

PI_NAMEs: HEEREN, TIMOTHY C. (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Adverse event;Affect;alcohol and other drug;Alcohol consumption;alcohol misuse;alcohol research;alcohol use disorder;Alcohols;antiretroviral therapy;Behavior Therapy;Behavioral;Biometry;Boston;Cardiovascular Diseases;career;chronic pain;Clinical Trials;Cognitive;cohort;Cohort Analysis;Cohort Studies;Collaborations;Collection;comorbidity;Data;Data Analyses;Data Collection;data management;Disease;drinking;Drug usage;Ecological momentary assessment;efficacy testing;Enrollment;exercise intervention;experience;extend lifespan;falls;frailty;Funding;Health;Health behavior;HIV;HIV Infections;HIV/AIDS;Home;Infection;Interdisciplinary Study;Intervention;Intervention Trial;Investigation;Lead;Life;Life Style;member;mental function;Mentors;mHealth;Motivation;National Institute on Alcohol Abuse and Alcoholism;older adult;Osteopenia;Outcome;Pain;Participant;Persons;Pharmaceutical Preparations;Physical activity;Physical Function;physical inactivity;Play;Population;Productivity;Public Health;randomized trial;Research;Research Design;Research Personnel;Research Project Grants;Resources;Risk;Risk Factors;Role;secondary analysis;Statistical Data Interpretation;telehealth;Testing;United States National Institutes of Health;Work

PROJECT_TITLE: Biostatistics and Data Management Core


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;HIV/AIDS;Health Services;Infectious Diseases;Microbiome;Prevention;Screening and Brief Intervention for Substance Misuse;Substance Misuse

ORG_CITY: LOUISVILLE

ORG_NAME: UNIVERSITY OF LOUISVILLE

ORG_STATE: KY

PHR: This longitudinal study systematically examines the dynamic changes in the gut microbiome (dysbiosis) in the context of regular use of PrEP with or without hazardous alcohol drinking. The study also pursues a randomized control trial (RCT) to determine the efficacy of SBIRT (Screening, Brief Intervention, & Referral to Treatment) in reducing the risk of alcohol drinking and associated pathogenic changes in the gut liver axis

PI_NAMEs: BARVE, SHIRISH S (contact);HARRIS, LESLEY BETH;KERR, JELANI

PROGRAM_OFFICER_NAME: PERRUCCIO, ELIZABETH M

PROJECT_TERMS: Address;Adherence;Adverse event;Affect;AIDS prevention;Alcohol abuse;Alcohol consumption;alcohol measurement;alcohol misuse;alcohol risk reduction;Alcohols;Ambulatory Care Facilities;appetite loss;attenuation;Behavioral;Biological;Caring;Clinic;Clinical;Clinical Research;Continuity of Patient Care;Data;Data Collection;Decision Making;dysbiosis;Early Intervention;Early treatment;Effectiveness;effectiveness testing;efficacy evaluation;enteric dysbiosis;Event;Exhibits;experience;Feedback;gastrointestinal;Goals;gut dysbiosis;gut microbiome;gut-liver axis;Health;Healthcare;HIV;HIV Seronegativity;improved;Individual;Injury to Kidney;Internal Medicine;Intervention;Interview;intestinal homeostasis;Intestinal permeability;Kidney Diseases;Liver diseases;liver function;liver injury;Longitudinal cohort study;Longitudinal Studies;Maintenance;microbial;microbial community;Movement;Nausea;Outcome;Participant;Pathogenicity;Pattern;Persons;Pharmaceutical Preparations;Population;pre-exposure prophylaxis;prevent;Process;Public Health;Qualitative Methods;Randomized;Randomized, Controlled Trials;Reaction;recruit;reduced alcohol use;Regimen;Research;Research Personnel;Risk;screening;screening, brief intervention, referral, and treatment;side effect;Structure;Subgroup;systemic inflammatory response;Testing;Time;transmission process;treatment as usual;Treatment Effectiveness;treatment program;Triage;Universities;uptake;Vomiting

PROJECT_TITLE: Alcohol Misuse, Gut Microbial Dysbiosis and PrEP Care Continuum: Application and Efficacy of SBIRT Intervention


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Gene Therapy;Gene Therapy Clinical Trials;Genetics;Hematology;Immunotherapy;Lymphatic Research;Lymphoma;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: DUARTE

ORG_NAME: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE

PHR: PROJECT NARRATIVE This proposal examines the safety and anti-tumor activity of CD19-directed chimeric antigen receptor (CD19- CAR) T cell immunotherapy for the treatment of primary central nervous system lymphoma (PCNSL). In this study, the CD19-CAR T cells will be delivered directly to the CNS by injection into the brain ventricle. The proposed clinical trial aims to give us a better understanding of CD19-CAR T cell activity following brain infusion, with the goal of improving the very poor outcomes of patients with PCNSL.

PI_NAMEs: FORMAN, STEPHEN J;SIDDIQI, TANYA ;WANG, XIULI  (contact)

PROGRAM_OFFICER_NAME: SONG, MIN-KYUNG H

PROJECT_TERMS: Address;Angiopoietins;Animal Model;Autologous;B-Cell Acute Lymphoblastic Leukemia;B-Lymphocytes;Biological Markers;Blood;Blood - brain barrier anatomy;Brain;CAR T cell therapy;CD19 gene;cell motility;Cell Physiology;Cells;Central Nervous System;Central Nervous System Diseases;Central Nervous System Lymphoma;Cerebral Ventricles;Cerebrospinal Fluid;Characteristics;chimeric antigen receptor T cells;Cities;Clinical;Clinical Trials;Cognitive;Correlative Study;cytokine;Data;design;Development;Disease;Distal;Dose;Endothelial Growth Factors;Endothelium;Environment;Evaluable Disease;Exclusion;FDA approved;follow-up;Funding;Future;Glioblastoma;Goals;Hematologic Neoplasms;Hematology;Human Resources;Immune;Immunologics;Immunotherapy;improved;improved outcome;in vivo;Infusion procedures;Injections;innovation;Intravenous;intravenous administration;Kinetics;Lymphoma;Malignant Neoplasms;manufacture;Maximum Tolerated Dose;Measures;Metabolic;Methotrexate;migration;Monitor;mouse model;Neuron-Specific Enolase;neurotoxicity;Non-Hodgkin's Lymphoma;non-Hodgkin's lymphoma patients;Outcome;Participant;Patient-Focused Outcomes;Patients;Peripheral;peripheral blood;Phase;phase 1 study;Phase I Clinical Trials;phase I trial;Phenotype;pre-clinical;Prognosis;Radiation therapy;Recommendation;Refractory;Regimen;Relapse;Reporting;Research Design;Resistance;response;Role;Safety;safety assessment;Series;Serum;side effect;standard of care;Survival Rate;Systemic disease;T-Cell Receptor Therapy;targeted treatment;Testing;Therapeutic;timeline;Toxic effect;trafficking;tumor;Vascular Endothelial Growth Factors;von Willebrand Factor;Xenograft procedure

PROJECT_TITLE: Intracerebroventricular (ICV) Administration of CD19-Targeting Chimeric Antigen Receptor (CAR) T cells for Treatment of Primary Central Nervous System Lymphoma

STUDY_SECTION: CONC

STUDY_SECTION_NAME: Clinical Oncology Study Section[CONC]


NIH_SPENDING_CATS: Aging;Biotechnology;Eye Disease and Disorders of Vision;Genetics;Human Genome;Macular Degeneration;Neurodegenerative;Neurosciences;Prevention;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_DEPT: OPHTHALMOLOGY

PHR: PROJECT NARRATIVE The back of the eye is composed of a light sensitive sheet of cells called photoreceptors that receive nourishment from supporting retinal pigment epithelial (RPE) cells. Each day, photoreceptor outer segments (OS) are shed and recycled by the RPE, which repurposes this material for delivery back to photoreceptors. Since defects in phagocytosis lead to dysfunction and degeneration of photoreceptors, our study aims to explore the role of genomic risk-variants for development of age-related macular degeneration and RPE phagocytosis efficiency.

PI_NAMEs: SKOWRONSKA-KRAWCZYK, DOROTA  (contact);WAHLIN, KARL J

PROGRAM_OFFICER_NAME: GORDIYENKO, NATALIYA

PROJECT_TERMS: age effect;age related;Age related macular degeneration;Antibodies;Apical;Back;Basal lamina;Biological Assay;Biological Markers;Blindness;Blood-Retinal Barrier;Cell Line;Cell membrane;Cell Polarity;cell type;Cells;Characteristics;Choroidal Neovascularization;chromophore;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Collecting Cell;complement C3 precursor;Coupled;Culture Media;Data;Defect;Deposition;Development;differential expression;Disease;Docosahexaenoic Acids;Drusen;Electroretinography;Electrospray Ionization;Endocytosis;Enzymes;Event;Exhibits;Exocytosis;experimental study;Eye;Eye diseases;Fatty Acids;Fluorescence;Functional disorder;Gene Expression Profile;genetic variant;Genomics;geographic atrophy;Growth Factor;Health;Heterogeneity;high risk;Homeostasis;Human;human induced pluripotent stem cells;Immunohistochemistry;In Vitro;induced pluripotent stem cell;Inflammatory;inflammatory modulation;Inflammatory Response;knockout gene;Laboratories;Lead;Light;Link;lipid metabolism;lipidomics;Lipids;Liquid Chromatography;mass spectrometer;Measures;Membrane;Methods;Modeling;Molecular;molecular marker;molecular phenotype;Mutation;Nature;novel;novel therapeutic intervention;novel therapeutics;participant enrollment;Pathogenesis;Pathology;patient derived induced pluripotent stem cells;Patients;Phagocytes;Phagocytosis;photoreceptor degeneration;Photoreceptors;Pigments;Play;Polyunsaturated Fatty Acids;potential biomarker;Predisposing Factor;prognostic indicator;Proteins;receptor binding;Recycling;Resistance;Retina;retinal rods;risk variant;Rod Outer Segments;Role;RPE65 protein;Sampling;Signal Transduction;Source;Stains;Structure of retinal pigment epithelium;System;Tight Junctions;tool;transcriptome sequencing;transcriptomics;U-Series Cooperative Agreements;Vision;visual cycle;Western Blotting

PROJECT_TITLE: Correlating Genomic AMD Risk Variants with Lipid Composition and Phagocytic Function of Patient-Derived Induced Pluripotent Stem Cell (iPSC)-derived Retinal Pigment Epithelium (RPE)


ORG_NAME: DANA-FARBER CANCER INST

ORG_STATE: MA

PHR: Project Narrative Despite the presence of thousands of mutations in the cancer genome, including over one hundred structural variants per genome, we lack a targeted therapy to treat many cancers. This proposal is designed to take advantage of the multiple structural variants in the cancer genome and use them as unique genomic sites for CRISPR nuclease targeting and cleavage, which in turn could lead to cancer cell cytotoxicity. This proposal will design, validate and characterize a multi-cut CRISPR approach to cause cytotoxicity in targeted cancer cells, while leaving normal cells intact, and is the first step in developing this approach to becoming a broad- spectrum cancer therapeutic in the future.

PI_NAMEs: LEIBOWITZ, MITCHELL L (contact)

PROGRAM_OFFICER_NAME: ELJANNE, MARIAM

PROJECT_TERMS: Affect;Age;Apoptosis;Apoptotic;Biological Assay;Biological Markers;cancer cell;Cancer cell line;cancer genome;cancer genomics;Cancer Patient;cancer therapy;cancer type;career;Cell Cycle;Cell Death;Cell Death Induction;cell killing;Cell Line;Cell Survival;cell type;Cells;Cessation of life;chemotherapy;Chromosomal Duplication;chromosome loss;chromosome missegregation;Chromosomes;chromothripsis;Clonality;Clustered Regularly Interspaced Short Palindromic Repeats;Coculture Techniques;Complex;computational pipelines;CRISPR/Cas technology;cytotoxic;Cytotoxic agent;cytotoxicity;Dana-Farber Cancer Institute;Data;data repository;design;Development;DNA;DNA Damage;DNA Double Strand Break;DNA Repair;DNA Sequence Alteration;DNA Sequence Rearrangement;Double Minutes;Effectiveness;Elements;Encyclopedias;Enzymes;Evaluation;Event;Excision;experience;experimental study;Future;Gene Rearrangement;Gene Targeting;Genes;Genome;genome database;genome editing;genomic locus;Genomics;Guide RNA;Hour;Human;Immunotherapy;improved;Institution;Investigation;Journals;Knock-out;Malignant Neoplasms;Measures;Mediating;Medical;Mentors;Methods;Modality;Mutate;Mutation;Natural Killer Cells;new therapeutic target;next generation;Normal Cell;novel;novel therapeutics;Nucleic Acids;Operative Surgical Procedures;Outcome;pan-genome;Pathway interactions;Patients;Peer Review;Predisposition;professor;Proteins;Publications;Radiation therapy;repaired;Research;research faculty;Resistance;Scientist;screening;Series;Site;small molecule;Stains;symposium;System;targeted nucleases;targeted treatment;Therapeutic;Tissues;tool;Toxic effect;Training;tumor;United States;Variant;whole genome

PROJECT_TITLE: Targeting the cancer neo-genome for destruction with CRISPR-Cas enzymes


NIH_SPENDING_CATS: Aging;Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Infectious Diseases;Physical Activity;Prevention;Substance Misuse

PI_NAMEs: QUINTILIANI, LISA M. (contact)

PROJECT_TERMS: acceptability and feasibility;Acute;Address;Affect;age acceleration;aging process;alcohol abstinence;Alcohol consumption;alcohol misuse;alcohol related problem;alcohol research;alcohol use disorder;antiretroviral therapy;Behavioral;Boston;Cessation of life;Chronic;Collaborations;comorbidity;coping;Counseling;Coupled;Data;drinking;Dropout;Ecological momentary assessment;efficacy testing;exercise intervention;Female;fitbit;fitness;follow-up;General Population;Goals;hazardous drinking;Health;Health education;Health Technology;Heavy Drinking;HIV;HIV/AIDS;Home;Individual;Intervention;intervention effect;Life Expectancy;Life Style;male;Measures;Mediating;Mental Depression;mental function;Mental Health;mHealth;mobile application;Monitor;Motivation;multiple chronic conditions;negative affect;older adult;Outcome;Participant;Persons;Physical activity;Physical assessment;physical conditioning;physical inactivity;Population;Populations at Risk;primary outcome;Public Health;Quality of life;Randomized;Randomized, Controlled Trials;Recording of previous events;recruit;Risk;secondary outcome;sedentary;sedentary lifestyle;Self Efficacy;Structure;Testing;Time;Work

PROJECT_TITLE: Increasing physical activity among persons living with HIV engaged in unhealthy drinking


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Dissemination and Implementation Research;Health Services;Nutrition;Obesity;Pediatric;Prevention

ORG_CITY: LITTLE ROCK

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIV OF ARKANSAS FOR MED SCIS

ORG_STATE: AR

PHR: PROJECT NARRATIVE Arkansas (AR) and Louisiana (LA), the target locations for the current study, are among the states with the highest cancer and obesity rates in the US. Effective prevention and intervention programs are needed to reduce the number of children who develop unhealthy dietary habits and become adults with obesity, two key risk factors for the development of cancer. This proposal will test an adaptive implementation strategy to optimize the adoption of evidence- based practices for nutrition promotion and obesity prevention in early care and education settings.

PI_NAMEs: SWINDLE, TAREN  (contact)

PROGRAM_OFFICER_NAME: AGURS-COLLINS, TANYA

PROJECT_TERMS: 5 year old;Adoption;Adult;adult obesity;Age;Antioxidants;Arkansas;Body mass index;cancer prevention;cancer risk;Caring;Child;Child Care;Child Health;Child Support;Climate;Consumption;Control Groups;cost;cost comparison;cost effectiveness;cost estimate;Data;design;Development;Diet;Diet Habits;dietary;dietary guidelines;Early Intervention;Eating;Education;effectiveness evaluation;Evidence based practice;experience;Exposure to;feeding;Fiber;Food;fruits and vegetables;Goals;good diet;Health;Health behavior;healthy weight;implementation efforts;implementation intervention;implementation outcomes;implementation strategy;improved;incremental cost-effectiveness;Informal Social Control;Intervention;intervention program;Knowledge;Leadership;Life;Location;Louisiana;Malignant Neoplasms;Measures;Mediating;Mediation;Mediator;Methods;mortality;nutrition;Obesity;obesity prevention;organizational readiness;Outcome;overweight child;Pattern;Perception;Policies;prevention practice;Prevention program;primary outcome;programs;Publishing;Randomized;Resources;response;Risk;Risk Factors;role model;Site;success;teacher;Testing;Training;uptake;Work;work-study

PROJECT_TITLE: Testing an Adaptive Implementation Strategy to Optimize Delivery of Obesity Prevention Practices in Early Care and Education Settings

STUDY_SECTION: SIHH

STUDY_SECTION_NAME: Science of Implementation in Health and Healthcare Study Section[SIHH]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;HIV/AIDS;Infectious Diseases;Lung;Lung Cancer;Prevention;Substance Misuse;Telehealth;Tobacco;Tobacco Smoke and Health

ORG_CITY: TAMPA

ORG_NAME: H. LEE MOFFITT CANCER CTR & RES INST

PHR: PROJECT NARRATIVE This project is a collaborative initiative between US researchers and Cambodian public health officials to determine the efficacy of a novel mHealth intervention for smoking cessation among Cambodian people living with HIV/AIDS. The proposed research is relevant to public health because it is ultimately expected to advance understanding of effective tobacco cessation approach in low- and middle-income settings, and subsequently reduce tobacco-induced cancer morbidity and mortality. It is expected that the treatment will be both effective and affordable, thus appropriate for widespread adoption in many resource-poor settings.

PI_NAMEs: BUI, THANH C.;VIDRINE, DAMON J. (contact)

PROGRAM_OFFICER_NAME: CORREA-MENDEZ, MARGARITA

PROJECT_TERMS: Abstinence;Address;Adoption;Adult;Adult women;antiretroviral therapy;Behavior Therapy;Biochemical;brief advice;Cambodia;Cambodian;Cancer Center;care delivery;Caring;Cellular Phone;cigarette smoke;Clinic;Collaborations;comparative cost effectiveness;Comprehensive Health Care;Confidence Intervals;Control Groups;cost effective;Country;Data;Developed Countries;Development;economic evaluation;efficacy evaluation;Enrollment;Evaluation;Female;follow-up;Health Promotion;Health Sciences;Healthcare;high risk;HIV;HIV/AIDS;improved;Income;Influentials;Intervention;Life;Literature;low income country;male;Mediator;men;mHealth;mhealth interventions;mobile computing;Modeling;Morbidity - disease rate;mortality;nicotine replacement;novel;Oklahoma;Participant;Patient Self-Report;Persons;Pharmacological Treatment;Phase;Pilot Projects;Prevalence;primary outcome;Proliferating;Public Health;Randomized;randomized trial;Randomized, Controlled Trials;recruit;Relative Risks;Reporting;Research;Research Personnel;Resource-limited setting;secondary outcome;self help;sexual identity;Smoke;smoking cessation;Smoking Cessation Intervention;smoking prevalence;Special Population;standard care;Surveys;tailored messaging;text messaging intervention;Tobacco;tobacco cessation intervention;tobacco control;Tobacco use;Tobacco Use Cessation;Tobacco-Related Carcinoma;Treatment Efficacy;treatment group;treatment program;Universities;University of Texas M D Anderson Cancer Center;Wireless Technology;World Health Organization;Writing

PROJECT_TITLE: Ending Tobacco Use through Interactive Tailored Messaging for Cambodian People Living with HIV/AIDS (EndIT)


ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE  Cell reprogramming represents a major advancement in biology, and has wide applications in regenerative medicine, disease modeling and drug screening. We will investigate how biophysical factors such as matrix stiffness can regulate the epigenetic state for cell reprogramming. Our findings will unravel the mechanisms of biophysical modulation of cell fate and provide a rational basis for the design of biomaterials for cell reprogramming.

PI_NAMEs: LI, SONG  (contact)

PROGRAM_OFFICER_NAME: BARNES, CHARLES ASHLEY

PROJECT_TERMS: Actins;Biocompatible Materials;Biological;Biology;Biophysical Process;Biophysics;Cardiac Myocytes;Cell Nucleus;Cell Physiology;Cell Reprogramming;cell type;Cells;cellular engineering;cofilin;Cues;Cytoskeleton;Data;depolymerization;design;Development;disease model;Distant;drug discovery;Drug Screening;Epigenetic Process;epigenomics;experience;Extracellular Matrix;F-Actin;Fibroblasts;Focal Adhesions;G Actin;Gene Expression;Gene Targeting;Genes;Genomics;Histone Acetylation;histone acetyltransferase;Induced Neurons;induced pluripotent stem cell;live cell imaging;Mediating;Microfilaments;migration;Modification;multidisciplinary;Neurons;novel;novel strategies;Nuclear;Nuclear Translocation;nucleocytoplasmic transport;Phenotype;Play;Process;Proliferating;Regenerative Medicine;Regulation;Repression;Role;Site;Somatic Cell;Surface;Testing;Tissue Engineering;transcription factor;transcriptomics;Transgenes;Work

PROJECT_TITLE: Regulation of cell reprogramming by matrix stiffness

STUDY_SECTION: ICI

STUDY_SECTION_NAME: Intercellular Interactions Study Section[ICI]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;HIV/AIDS;Health Services;Infectious Diseases;Networking and Information Technology R&D (NITRD);Pain Research;Prevention;Substance Misuse;Telehealth

PI_NAMEs: PALFAI, TIBOR P. (contact)

PROJECT_TERMS: Absenteeism at work;acceptability and feasibility;Address;Adherence;Aftercare;Age;age related;Alcohol consumption;alcohol intervention;alcohol misuse;alcohol related consequences;alcohol research;alcohol response;alcohol use disorder;Alcohols;anxiety symptoms;Arthritis;Behavior;Behavior Therapy;Behavioral;Boston;brief advice;Caring;Cellular Phone;Child Care;chronic pain;chronic pain management;Cognitive;Cognitive Therapy;Collaborations;community setting;comorbidity;Complication;Computer software;daily functioning;depressive symptoms;Development;Distant;drinking;Dropout;Ecological momentary assessment;Economics;efficacy testing;environmental stressor;Face;feasibility testing;follow-up;Frequencies;functional outcomes;functional status;Health;health care settings;Health Personnel;Heavy Drinking;HIV;HIV risk;HIV/AIDS;improved;indexing;insight;Intervention;intervention effect;Interview;Measures;Mediating;Mediator;Medical;medical specialties;mental function;Methods;Modality;Morbidity - disease rate;mortality;Motivation;Neuropathy;Nonpharmacologic Therapy;Online Systems;Outcome;Outcome Assessment;Pain;Pain interference;Pain management;pain outcome;Patient Compliance;Patient Self-Report;Patients;Persons;Pharmaceutical Preparations;pharmacologic;Pharmacological Treatment;phosphatidylethanol;Physical Capacity;Physical Function;pilot test;Population;primary outcome;Procedures;Process;Psyche structure;Questionnaires;Randomized, Controlled Trials;Recommendation;Recording of previous events;remote intervention;Research;Resources;Risk;Risk Taking;Severities;social stigma;substance use;Symptoms;Technology;telehealth;therapy design;Time;Transportation;Treatment Efficacy;Videoconferencing;web site;Work

PROJECT_TITLE: Integrated telehealth intervention to reduce chronic pain and unhealthy drinking among people living with HIV


NIH_SPENDING_CATS: Biotechnology

ORG_CITY: CAMBRIDGE

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

PHR: PROJECT NARRATIVE  The site-selective functionalization of biomolecules including proteins and complex biologically active small molecules represents a frontier in modern bioconjugation. The following proposal details the use of peptide- conjugated palladium oxidative addition complexes to modify important protein and biologically active small molecule targets in a highly modular and general approach. Leveraging the ability of user-defined peptide sequences to direct the C–heteroatom bond-forming chemistry of palladium complexes will allow for site- selective “traceless” modification of biomolecules, which is expected to enable a powerful discovery platform for chemical biology and the preparation of novel therapeutics.

PI_NAMEs: KUTATELADZE, DENNIS A. (contact)

PROGRAM_OFFICER_NAME: JONES, LATAISIA CHERIE

PROJECT_TERMS: Active Sites;Affinity;Air;Antibody-drug conjugates;aqueous;aryl halide;Binding;Binding Proteins;Binding Sites;Biocompatible Materials;Biological Process;Biology;catalyst;Chemicals;Chemistry;combinatorial;Complex;Coupling;Cysteine;Derivation procedure;Development;drug discovery;drug structure;Engineering;Faculty;frontier;Goals;Health;Human;human disease;interest;Label;Laboratories;Link;Lysine;Mass Spectrum Analysis;Massachusetts;Medicine;metalloenzyme;Metals;Methods;Modernization;Modification;Natural Products;Nature;novel therapeutics;Nucleic Acids;Organometallic Chemistry;Palladium;peptide structure;Peptide Synthesis;Peptides;Pharmaceutical Preparations;Pharmacologic Substance;Physiological;Polyamines;polyol;Positioning Attribute;post-doctoral training;Post-Translational Protein Processing;Preparation;Process;Production;protein aminoacid sequence;protein degradation;protein function;Proteins;R peptide;Reaction;Reagent;Research;Secure;Site;skills;small molecule;Structure;Structure-Activity Relationship;Techniques;Technology;Training;United States National Institutes of Health;Universities

PROJECT_TITLE: Peptide-Conjugated Palladium Oxidative Addition Complexes for Site-Selective Arylation Chemistry


NIH_SPENDING_CATS: Bioengineering;Cancer;Cervical Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Services;Infectious Diseases;Prevention;Primary Health Care;Sexually Transmitted Infections;Women's Health Research

PHR: Public Health Relevance The I-REACH project aims to prevent cervical cancer by adapting an HPV self-test assay and then developing innovative design and implementation strategies for HPV self-testing among screen-eligible women in Nigeria. The project will center women and provide opportunities for them to define, implement, and evaluate innovative HPV self-testing strategies. The engineering and clinical validation of our HPV self-test kits will allow a more rapid, inexpensive, user-friendly, and widely available sensitive and specific, point-of-care test that women can perform by themselves, thereby transforming the cervical cancer screening landscape in Nigeria and other low- and middle-income countries.

PI_NAMEs: CHANG, YIE-HWA ;EZECHI, OLIVER CHUKWUJEKWU;IWELUNMOR, JULIET  (contact);TUCKER, JOSEPH DAVID

PROGRAM_OFFICER_NAME: SAHASRABUDDHE, VIKRANT V

PROJECT_TERMS: Acceleration;Acetic Acids;aged;American;Area;Benchmarking;Biological Assay;Caring;Cervical;cervical cancer prevention;Cervical Cancer Screening;Cervical Intraepithelial Neoplasia;Cessation of life;Clinic;Clinical;Clinical Sensitivity;Clinical Trials Data Monitoring Committees;community based participatory research;Community Health Aides;Community Healthcare;cost;Country;Coupled;crowdsourcing;Data;Decentralization;design;Detection;Development;Diagnostic;diagnostic criteria;Diagnostic Reagent Kits;Discipline of obstetrics;disorder risk;DNA;Early Diagnosis;Eligibility Determination;Engineering;Equipment;Evaluation;experience;Foundations;Freeze Drying;Genotype;Geographic Locations;Government;Gynecology;Health;Health Personnel;high risk;HIV;HPV screening;HPV-High Risk;Human papilloma virus 31;Human Papillomavirus;Human papillomavirus 16;Human papillomavirus 18;implementation strategy;Individual;innovation;Institutional Review Boards;Instruction;isothermal amplification;lateral flow assay;Learning;learning community;Letters;Local Government;low and middle-income countries;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Mediating;Methods;middle age;Minority Women;multidisciplinary;Nigeria;Nigerian;Ownership;Pap smear;Participant;Performance;Phase;point of care;point of care testing;prevent;Prevention program;primary health center;primary outcome;Privacy;Problem Solving;Procedures;Process;Protocols documentation;prototype;public health relevance;Randomized;Randomized, Controlled Trials;Readiness;Recommendation;recruit;Request for Applications;Research;research study;Resource-limited setting;Risk;risk variant;Sampling;scale up;screening;Screening procedure;Screening Result;secondary outcome;self testing;Sensitivity and Specificity;Services;Societies;Specificity;Specimen;Swab;Technology;Testing;treatment as usual;United States National Institutes of Health;uptake;user-friendly;Validation;Visual;Woman;Youth

PROJECT_TITLE: Innovative Rapid Enabling, Affordable, point-of-Care HPV Self-Testing Strategy (I-REACH)


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Dental, Oral, and Craniofacial Disease;Infectious Diseases;Microbiome;Nanotechnology;Prevention

ORG_CITY: PHILADELPHIA

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Our goal is to develop a more effective and targeted caries preventive approach for susceptible populations. It integrates a multifunctional strategy that disrupts virulent biofilms and prevents enamel demineralization under high cariogenic conditions. The agents are low cost and approved for clinical use facilitating product development

PI_NAMEs: KOO, HYUN  (contact)

PROGRAM_OFFICER_NAME: MCNEALY, TAMARA L

PROJECT_TERMS: Acids;Affect;analog;anticaries;antimicrobial;Apatites;Area;Award;Binding;Biocompatible Materials;Biodistribution;Biological;Caries prevention;Catalysis;Chemicals;Clinical;clinical efficacy;Clinical Research;clinical translation;Clinical Trials;clinically relevant;Combined Modality Therapy;Communication;comparative efficacy;cost;Data;demineralization;dental biofilm;Dental caries;Dental Enamel;Development;Dextrans;Dose;effective therapy;Effectiveness;efficacy study;Enzymes;FDA approved;ferumoxytol;Fluorides;Formulation;Funding;Funding Mechanisms;Gingiva;Goals;gut microbiome;Hardness;Human;Hydrogen Peroxide;improved;In Situ;In Vitro;in vivo;Individual;Industry;Intellectual Property;internal control;iron deficiency;Iron deficiency anemia;iron oxide nanoparticle;Knowledge;Laboratories;Legal patent;Medical;metabolomics;Metagenomics;Methods;Microbial Biofilms;Microscopy;Modality;Modeling;Mouth Diseases;Mucous Membrane;multiple omics;nano;nanoparticle;Nature;new technology;novel;novel strategies;Oral;oral microbiome;Oral mucous membrane structure;oral tissue;Organ;Pathologic;Performance;Peroxidases;Physical Chemistry;polymicrobial biofilm;Population;Poverty;Precision therapeutics;Predisposition;prevent;Preventive;product development;Property;Publications;Radiolabeled;Regimen;response;Rodent;Rodent Model;safety and feasibility;Small Business Innovation Research Grant;soft tissue;Source;Specificity;Spectrum Analysis;Structure;Study models;sugar;Surface;synergism;Technology;Testing;tomography;Topical application;Toxic effect;transcriptomics;Treatment Efficacy;Treatment Protocols;Virulent;Work

PROJECT_TITLE: Biofilm Elimination and Caries Prevention using Multifunctional Nanocatalysts


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Brain Disorders;Emerging Infectious Diseases;Infectious Diseases;Neurodegenerative;Neurosciences;Rare Diseases;Transmissible Spongiform Encephalopathy (TSE)

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: 8. Project Narrative The misfolding of proteins into amyloid aggregates has been associated with more than fifty human diseases, including familial, sporadic and transmissible neurodegenerative diseases, type II diabetes, and familial hypertension. Our current understanding of how amyloid arises, disrupts normal physiology, and can be reversed is limited. Our proposed studies will advance our understanding of these characteristics by focusing on the barriers to transitions between states in yeast, which will inform our understanding of disease dynamics and treatment in man.

PI_NAMEs: SERIO, TRICIA R. (contact)

PROGRAM_OFFICER_NAME: MASKERI, BAISHALI

PROJECT_TERMS: Amino Acid Sequence;Amyloid;amyloid formation;amyloidogenesis;Appearance;Biology;Cellular biology;Characteristics;Complex;conformational conversion;Disease;Equilibrium;Eukaryota;Event;familial hypertension;Goals;human disease;Individual;Knowledge;Link;man;Modeling;Molecular;Neurodegenerative Disorders;Non-Insulin-Dependent Diabetes Mellitus;Organism;Outcome;Pathway interactions;Phenotype;Physiological;Physiology;Prions;Process;Protein Conformation;protein misfolding;Proteins;Quality Control;Resolution;Saccharomyces cerevisiae;System;Systems Biology;Toxic effect;transmission process;yeast prion;Yeasts

PROJECT_TITLE: Cellular Mechanisms and Consequences of Protein Misfolding and Resolution