ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Cardiovascular;Comparative Effectiveness Research;Emergency Care;Heart Disease;Neurosciences;Patient Safety;Physical Injury - Accidents and Adverse Effects

ORG_CITY: ANN ARBOR

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: The Strategies to Innovate Emergency Care Clinical Trials Network (SIREN) is an international multicenter clinical trials network. SIREN physicians and researchers study what treatments work best for patients with emergency conditions or injuries. Emergencies may involve heart, lung, or blood conditions, problems or injuries involving the brain or spinal cord, seizures, coma, or other traumatic injuries. The SIREN will study patients in ambulances and emergency departments, and the earliest stages of critical care, because many promising treatments may only work well if they are given very quickly after the onset of symptoms or injury.

PI_NAMEs: BARSAN, WILLIAM G;CALLAWAY, CLIFTON W.;SILBERGLEIT, ROBERT  (contact)

PROGRAM_OFFICER_NAME: SCOTT, GRETCHEN CARLYLE

PROJECT_TERMS: Accident and Emergency department;Acute;acute care;Ambulances;Ancillary Study;Applications Grants;Attenuated;Blood;Brain;Budgets;Cardiac;Caring;Clinical;Clinical Investigator;clinical trial enrollment;Clinical Trials;Clinical Trials Design;Clinical Trials Network;Collaborations;Coma;Community Trial;Conduct Clinical Trials;confirmatory clinical trial;Contracts;cost;COVID-19;COVID-19 pandemic;Creativeness;Critical Care;Data;data management;design;Development;Early Intervention;effective therapy;Effectiveness;electronic consent;Elements;Emergency Care;Emergency Department Physician;Emergency research;emergency settings;Emergency Situation;Emergency treatment;Enrollment;Ensure;expectation;experience;FDA approved;Funding;Goals;Grant;Healthcare;Heart;Heart Arrest;Hematology;Human;improved;improved outcome;Information Technology;Informed Consent;Injury;innovation;Intensive Care Units;Interdisciplinary Study;International;Intervention;Investigation;Leadership;Lung;Methods;Mission;Morbidity - disease rate;mortality;Multi-Institutional Clinical Trial;Multicenter Trials;multidisciplinary;Myocardial Infarction;Neurologic;Neurological emergencies;Neurologist;Neurosurgeon;novel;Online Systems;Outcome;pandemic disease;participant enrollment;Patient Care;patient engagement;Patient-Focused Outcomes;Patients;Physicians;pre-clinical research;Pre-hospital setting;Principal Investigator;Process;Productivity;quality assurance;recruit;Research;Research Infrastructure;Research Personnel;Resources;respiratory;response;Resuscitation;screening;Seizures;Site;Spinal Cord;spinal cord and brain injury;Structure;success;Surgeon;Symptoms;Translational Research;Translations;Trauma;Traumatic injury;treatment trial;trial planning;United States National Institutes of Health;Work

PROJECT_TITLE: Strategies to Innovate EmeRgENcy Care Clinical Trials Network (SIREN) - Clinical Coordinating Center (CCC)


ADMINISTERING_IC: AI

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: PORTLAND

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: PORTLAND VA RESEARCH FOUNDATION, INC.

ORG_STATE: OR

PHR: Narrative Cytomegalovirus disease is a major opportunistic infection in immunosuppressed hosts. Characterizing the viral mutations that confer resistance to existing and new antiviral drugs is important in the genotypic diagnosis of resistance, cross-resistance and the selection of alternate therapy. Detailed understanding of the genetic mechanisms of resistance will inform the development of additional candidate drugs and antiviral targets.

PI_NAMEs: CHOU, SUNWEN  (contact)

PROGRAM_OFFICER_NAME: DAVIS, MINDY I

PROJECT_TERMS: active method;Alternative Therapies;Anti-viral Agents;anti-viral efficacy;Anti-viral Therapy;Area;Cells;Cidofovir;clinical diagnosis;clinical diagnostics;clinical practice;comparative;cost;Cytomegalovirus;Cytomegalovirus Infections;Data;deep sequencing;design;Development;Diagnosis;Disease;DNA Polymerase Inhibitor;DNA-Directed DNA Polymerase;drug candidate;Drug Exposure;Drug resistance;Evolution;experience;Exposure to;fitness;Foscarnet;Future;Ganciclovir;Genes;Genetic;Genetic Polymorphism;Genotype;Human;Immunocompromised Host;improved;In Vitro;in vivo;inhibitor;kinase inhibitor;Laboratories;Malignant Neoplasms;maribavir;Mission;Morphologic artifacts;Mutation;novel;Opportunistic Infections;Oral;Pathway interactions;Pharmaceutical Preparations;phase III trial;Phenotype;Phosphotransferases;Point Mutation;Predisposition;Prodrugs;Prophylactic treatment;receptor;Recombinants;Research;Resistance;resistance gene;resistance mechanism;resistance mutation;Resistance profile;Specimen;stem cells;terminase;Therapeutic;Toxic effect;Transplant Recipients;Tropism;Valganciclovir;Variant;Viral;viral detection;viral DNA;virus testing;whole genome

PROJECT_TITLE: Genetic Pathways of Human Cytomegalovirus Drug Resistance

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AIDC-B(82)]


ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Genetics;Infectious Diseases;Lung

ORG_CITY: STANFORD

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: PROJECT NARRATIVE Efforts towards understanding how SARS-CoV-2 causes lung disease have been hampered by a lack of studies in novel circulating variants and a lack of relevant human lung models. The proposed studies will use a panel of primary viral variants and advanced single-cell analyses to study the early interferon response in novel lung organoid and slice cultures. Successful completion of this project will reveal mechanisms of SARS-CoV-2 pathogenesis and launch my career in the study of the host response to acute respiratory infections.

PI_NAMEs: RUSTAGI, ARJUN  (contact)

PROGRAM_OFFICER_NAME: ARNOLD, MICHELLE MARIE

PROJECT_TERMS: 2019-nCoV;3-Dimensional;Acute;acute infection;Acute respiratory infection;Advisory Committees;Air;Alveolar Cell;Alveolar Macrophages;Animals;Autoantibodies;Automobile Driving;Basal Cell;Biology;career;career development;Cell Communication;Cell Line;cell type;Cells;Cessation of life;combat;Communicable Diseases;COVID-19;COVID-19 pandemic;COVID-19 pathogenesis;COVID-19 patient;cytokine;Data;Dependence;design;Development;Development Plans;Disease;Emerging infection;Environment;Epithelial Cells;Epithelium;Event;Flow Cytometry;Funding;Gene Expression;Genes;global health;Goals;high risk;Human;IL18 gene;Immune;immune activation;immune cell infiltrate;Immune response;Immunity;Immunology;In Vitro;in vivo;Infection;Inflammation;Inflammatory;Inflammatory Response;innate immune pathways;Innate Immune Response;insight;instructor;Interferon Type I;Interferons;Interleukin-6;Knowledge;Liquid substance;Lung;Lung Diseases;Macrophage;Macrophage Activation;Manuscripts;Maps;Mentors;Microscopy;Modeling;Mucous Membrane;Mutation;nasopharyngeal swab;novel;novel diagnostics;novel therapeutic intervention;novel therapeutics;Organoids;pandemic disease;Pathogenesis;Pathogenicity;Pathway interactions;Patients;Physicians;Play;Positioning Attribute;Process;Productivity;programs;Protein Analysis;protein expression;Quantitative Reverse Transcriptase PCR;remdesivir;Research;Resources;respiratory;respiratory pathogen;respiratory virus;response;Rest;RNA amplification;Role;Sampling;SARS-CoV-2 infection;SARS-CoV-2 pathogenesis;SARS-CoV-2 variant;Scientist;severe COVID-19;Signal Transduction;single cell analysis;single-cell RNA sequencing;Slice;statistics;stem cells;Stimulus;Structure of parenchyma of lung;success;Supporting Cell;System;targeted treatment;Techniques;Testing;Therapeutic Intervention;TNF gene;tool;Training;Transcript;Tropism;Universities;vaccine delivery;vaccine hesitancy;Variant;variant of interest;variants of concern;Viral;Viral Pathogenesis;Viral Proteins;Virus;Virus Replication;Work

PROJECT_TITLE: Modeling early SARS-CoV-2 pathogenesis in human lung organoids and slice cultures

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases B Research Study Section[MID-B]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics

ORG_CITY: CHAMPAIGN

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

ORG_STATE: IL

PHR: PROJECT NARRATIVE Mapping the interactions between stress-inducible bacterial small RNAs and their mRNA partners will provide novel insights into regulatory networks. We propose to elucidate how small RNA regulators control target mRNAs to achieve precise control of complex physiological traits, including virulence. Systematic and quantitative analyses of a variety of small RNAs will expand our understanding of regulatory networks in bacteria, which may stimulate development of new therapeutic strategies for combating pathogens.

PI_NAMEs: VANDERPOOL, CARIN K (contact)

PROGRAM_OFFICER_NAME: RIGAS, MARC

PROJECT_TERMS: Address;Bacteria;Bacterial Genome;Bacterial Physiology;Base Pairing;Biochemistry;biological adaptation to stress;Biological Models;Biology;Cell Physiology;Cellular Structures;Complex;Development;Environment;Escherichia coli;Foundations;Funding;Gene Expression;Gene Expression Regulation;Genetic;Genomic approach;in vivo Model;insight;Link;Maps;Mediating;Mediator;Messenger RNA;metabolic phenotype;Microbe;Molecular;Molecular Biology;mRNA Stability;mutant;novel;novel therapeutic intervention;Outcome;pathogen;Physiological;Post-Transcriptional Regulation;Prevalence;Productivity;Regulation;Regulon;Research;RNA;Role;Salmonella;Small RNA;Stress;Techniques;trait;Transcription Elongation;Translations;Virulence;Work

PROJECT_TITLE: Small RNA Regulation in Bacteria

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-E(55)R]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Intellectual and Developmental Disabilities (IDD);Mental Health;Mental Illness;Pediatric

ORG_CITY: Aurora

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative  Having previously demonstrated that a 10-week therapeutic horseback riding (THR) intervention produces significant medium effect size improvements in irritability, hyperactivity, social communication, social cognition, and word fluency in youth with ASD compared to controls, the current proposal will: (1) examine putative physiological mediators hypothesized to contribute to these as well as expanded outcomes; (2) evaluate the six-month durability of outcomes compared to controls; and (3) explore dose and sub-population effects of the intervention. We target a more impaired majority ASD subpopulation, youth ages 6-16 yrs. with psychiatric diagnoses, who may be more likely to benefit from THR given preliminary evidence of stronger positive outcomes of THR in this subgroup. We have demonstrated the feasibility of collecting ambulatory physiological data during THR in the target population, and now seek to determine if THR is a viable adjunctive intervention able to improve biologically measurable arousal states and associated outcomes (i.e., irritability, hyperactivity, social, communication, emotion regulation and caregiver quality of life) for the majority ASD population, those with co-occurring psychiatric diagnoses.

PI_NAMEs: GABRIELS, ROBIN L (contact)

PROGRAM_OFFICER_NAME: ESPOSITO, LAYLA E

PROJECT_TERMS: Accreditation;Address;adolescent with autism spectrum disorder;Affect;Age;alternative treatment;Ambulatory Care Facilities;Animals;Anxiety;Arousal;autism spectrum disorder;Behavior;Cardiovascular system;caregiver quality of life;Caregivers;Clinical;Collaborations;Colorado;Communication;Communities;comparison control;comparison intervention;Control Groups;cost;Data;Data Collection;Diagnostic;disability;Dose;emotion dysregulation;emotion regulation;Equus caballus;experience;Family;follow-up;Future;Goals;group intervention;health care service utilization;Heart Rate;heart rate variability;Human;Hybrids;Hydrocortisone;Hyperactivity;Impairment;improved;Individual;individuals with autism spectrum disorder;inpatient psychiatric treatment;interest;International;Intervention;intervention effect;invention;Investigation;Life;Maintenance;Manuals;Measurable;Measures;Mediating;Mediator;Mental Depression;Mental disorders;Mental Health;Outcome;Outcome Measure;Participant;Pattern;Peripheral;Phase;Physiological;Population;post intervention;Prevalence;programs;Psychiatric Diagnosis;Psychiatric Hospitals;Psychiatric therapeutic procedure;Psychophysiology;Public Health;Quality of life;Randomized;Randomized, Controlled Trials;recruit;Research;Research Personnel;response;Salivary;Site;skills;social;social cognition;social communication;Social Functioning;Source;Stress;Structure;study population;Subgroup;Target Populations;Testing;Therapeutic;Therapeutic Effect;therapy outcome;Waiting Lists;Youth

PROJECT_TITLE: Physiological mechanisms of action relating to immediate and long-term therapeutic horseback riding intervention effects in a psychiatric population of youth with autism spectrum disorder

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BBBP-T(55)]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Congenital Structural Anomalies;Genetics;Hearing Loss;Neurosciences;Pediatric

ORG_CITY: SALT LAKE CITY

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Project Narrative Permanent hearing loss caused by malformation of the inner ear or congenital or progressive loss of its sensory or neural cells affects up to one third of individuals by the age of 80 and generates significant social and healthcare costs. In this proposal, we use mouse models to investigate the role of the Fibroblast Growth Factor signaling pathway in forming the inner ear epithelium and neurons. Our results will contribute new knowledge to the long-term goal of harnessing developmental signals to drive hearing restoration.

PI_NAMEs: MANSOUR, SUZANNE L (contact)

PROGRAM_OFFICER_NAME: FREEMAN, NANCY

PROJECT_TERMS: Ablation;Address;Affect;Age;Auditory;Candidate Disease Gene;Cell Differentiation process;Cell Survival;cell type;Cells;Cochlea;Cochlear implant procedure;combinatorial;conditional knockout;conditional mutant;Data;Defect;Development;Dominant-Negative Mutation;Doxycycline;Epithelium;Equilibrium;extracellular;FGF10 gene;FGF3 gene;Fibroblast Growth Factor;fibroblast growth factor receptor 2b;Fibroblast Growth Factor Receptors;Future;Ganglia;gene function;Generations;Genes;genetic approach;genome-wide analysis;Goals;Health Care Costs;Hearing;hearing impairment;hearing restoration;In Vitro;in vivo;Individual;inner ear development;Investigation;Knockout Mice;Knowledge;Labyrinth;Ligands;light intensity;loss of function;Maintenance;malformation;Mediating;Mesenchymal;Messenger RNA;Molecular;molecular marker;Morphogenesis;Morphology;mouse model;Mus;mutant;nerve supply;neural;neuroblast;neurogenesis;Neurons;novel;Otic Placodes;otoconia;overexpression;Pattern;permanent hearing loss;Phenotype;Proliferating;Receptor Protein-Tyrosine Kinases;Regulation;Repression;Role;Sensory;Signal Pathway;Signal Repression;Signal Transduction;Signaling Molecule;social;Specific qualifier value;spiral ganglion;System;Testing;Tissues;transcription factor;Transplantation;vestibular system

PROJECT_TITLE: Regulation of inner ear development by FGF signals and effectors

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: Project Narrative Bacteria are often starving and live in stressful environments. To best survive these conditions, most bacteria exist in a state of non-growth. Bacteria must therefore change their metabolism in order to conserve energy and this proposal aims to understand how this occurs.

PI_NAMEs: DWORKIN, JONATHAN  (contact)

PROGRAM_OFFICER_NAME: VATAKIS, DIMITRIOS NIKOLAOS

PROJECT_TITLE: Regulation of protein synthesis during quiescence in bacteria

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-S(55)R]


ADMINISTERING_IC: HL

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Clinical Research;Heart Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: BALTIMORE

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: RELEVANCE TO PUBLIC HEALTH  The goal of the proposed research is to use a novel combination of imaging, artiﬁcial intelligence, elec- troanatomical mapping, and mechanistic computational modeling to characterize atrial remodeling and under- stand the causes for atrial ﬁbrillation recurrence in rhythm-controlled patients. Successful execution of the project will pave the way for a paradigm shift in the clinical procedure of atrial ﬁbrillation ablation and in the quest to eliminate repeat procedures, resulting in a dramatic improvement in the efﬁcacy of the therapy. The project will culminate in a pilot prospective patient study that will test the new ablation strategy.

PI_NAMEs: KHOLMOVSKI, EUGENE ;SPRAGG, DAVID ;TRAYANOVA, NATALIA A. (contact)

PROGRAM_OFFICER_NAME: SOPKO, GEORGE

PROJECT_TERMS: Ablation;American;Arrhythmia;Artificial Intelligence;artificial intelligence model;Atrial Fibrillation;Cardiac ablation;cardiac magnetic resonance imaging;Catheters;Clinical;Clinical Data;clinically significant;Computer Models;contrast enhanced;deep learning;deep reinforcement learning;Development;Diagnosis;Disease;economic impact;Electrophysiology (science);Environment;Evolution;Fibrosis;Functional impairment;global health;Health Care Costs;health goals;Heart Atrium;heart rhythm;Image;improved;indexing;individual patient;insight;Knowledge acquisition;Lead;Learning;Link;Longitudinal Studies;Machine Learning;Maps;Medical;Modeling;Morbidity - disease rate;Morphology;mortality;novel;novel strategies;patient stratification;Patients;personalized strategies;Pharmaceutical Preparations;Population;Prevention;Procedures;prospective;Psychological reinforcement;Public Health;Pulmonary veins;Recommendation;Recurrence;Refractory;Research;risk minimization;Role;Shapes;stem;Structure;success;Testing;Time;Treatment Efficacy;treatment optimization

PROJECT_TITLE: Artificial intelligence analysis of atrial remodeling evolution in patients with atrial fibrillation: Towards optimal ablation strategies

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-TDPS-R(01)]


NIH_SPENDING_CATS: Behavioral and Social Science

ORG_DEPT: ANATOMY/CELL BIOLOGY

PHR: This program will increase the number of diverse students who enter top PhD graduate programs nationwide, tapping a major underrepresented pool of scientific talent essential for American innovation in basic biomedical research, biotechnology and pharmaceutics. Each year seven college graduates from groups under- represented in science (underrepresented minority or disability) will be competitively selected for a year of intensive basic biomedical research training in a Johns Hopkins laboratory, monthly scientific communication skill-building interactions with dedicated peer-mentors, monthly custom mentoring by the program director, and tri-yearly `mini-thesis' discussions with their chosen teams of scientifically-expert faculty advisors, in addition to ethics training and writing/peer-editing workshops to achieve long-term success in PhD or MD/PhD careers.

PI_NAMEs: WILSON, KATHERINE L (contact)

PROGRAM_OFFICER_NAME: AKACEM, LAMEESE DANA

PROJECT_TERMS: African American;Agreement;Alaska Native;American;American Indians;Area;Award;Awareness;Biomedical Research;Biotechnology;Black race;career;Clinical;college;Communication;Communities;Competence;Custom;Dedications;design;Development;Development Plans;disability;Disability accommodations;Doctor of Philosophy;doctoral student;education research;Educational process of instructing;Educational workshop;Enrollment;Environment;Ethics;Evaluation;Event;experience;experimental study;Faculty;Feedback;Fellowship;Fostering;Foundations;Funding;Future;Goals;graduate school;GRE Preparation;Hawaiian;Hispanic;Hour;improved;Individual;innovation;Institution;interest;Interview;Journals;Laboratories;Latino;Learning;Life;matriculation;Measures;medical schools;meetings;member;Mentors;minority trainee;Pacific Islands;peer;peer coaching;Personal Financing;Personal Growth;Persons;Pharmacy (field);Postbaccalaureate;Postdoctoral Fellow;Preparation;programs;recruit;Research;Research Ethics;Research Training;Schedule;Scholars Program;Science;Scientist;Self Efficacy;Series;skills;Students;success;support network;symposium;Talents;Testing;Time Management;Training;Training Programs;Underrepresented Minority;underrepresented minority student;Underrepresented Populations;Universities;visiting scholar;Visualization;Work;Writing

PROJECT_TITLE: HopkinsPREP: Research, Community, Professional Training and Personal Growth

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - C[TWD-C]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Complementary and Integrative Health;Dietary Supplements;Digestive Diseases;Genetics;Liver Disease;Neurosciences;Nutrition;Prevention

ORG_CITY: CLEVELAND

ORG_DEPT: NUTRITION

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: Vitamin E is an essential nutrient that is required for the integrity of cells, especially those of the nervous system. TTP is a protein expressed in the liver and the brain that regulates the levels and distribution of vitamin E in the body. We propose to study new, previously-undescribed functions of vitamin E and TTP and how they offer protection from disease. Upon the successful completion of the proposed studies, we will have resolved fundamental enigmas regarding the biology of vitamin E and TTP. These findings stand to influence a paradigm shift, likely to have profound impact on our understanding and treatments of relevant disease states.

PI_NAMEs: MANOR, DANNY  (contact)

PROGRAM_OFFICER_NAME: MARUVADA, PADMA

PROJECT_TERMS: Affinity;alpha Tocopherol;alpha-tocopherol transfer protein;Animal Behavior;Antioxidants;Area;ataxia with vitamin E deficiency;Binding;Biochemistry;Biological;Biology;Biophysics;Brain;Cell membrane;Cells;Cellular biology;Central Nervous System;Cerebellum;Cirrhosis;Clinical Trials;design;dietary;Dietary Component;Dietary Fats;Disease;effective intervention;Epidemic;Fatty acid glycerol esters;Fatty Liver;Fibrosis;Free Radicals;Future;Gene Expression;Gene Expression Profile;Genes;Genetic Models;Genetic Transcription;Genomics;Goals;Health;Health Promotion;Hepatic;Hepatocyte;hepatoprotective;Heritability;Homeostasis;Human;human disease;In Vitro;in vivo;Inflammation;insight;Lipid Peroxidation;Lipids;Lipoproteins;Liver;Liver diseases;liver injury;liver transplantation;Mediating;Membrane;Molecular;molecular imaging;mouse model;multidisciplinary;Mus;Mutation;Nervous System;Nervous System Disorder;Nervous System Trauma;Neurologic;Neurologic Dysfunctions;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;novel;Nucleic Acids;Nutrient;Obesity;Online Mendelian Inheritance In Man;Organelles;Organic Chemistry;Organism;Outcome;Pathologic;Pathology;Patients;Phosphatidylinositols;Physiological;Plants;Play;prevent;Process;protein function;protein transport;Proteins;Research;Risk;Role;severe injury;Site;Supplementation;Testing;Therapeutic Intervention;Tissues;Tocopherols;trafficking;trait;transcription factor;translational impact;TTPA gene;Vertebrates;vesicle transport;vitamin analog;Vitamin E;Vitamin E Deficiency;Vitamins

PROJECT_TITLE: Functions of vitamin E and the tocopherol transfer protein

STUDY_SECTION: INMP

STUDY_SECTION_NAME: Integrative Nutrition and Metabolic Processes Study Section[INMP]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Child Abuse and Neglect Research;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurosciences;Pediatric;Prevention;Sleep Research;Social Determinants of Health;Violence Research;Youth Violence;Youth Violence Prevention

ORG_CITY: HOUSTON

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF HOUSTON

ORG_STATE: TX

PHR: PROJECT NARRATIVE Sleep disturbances are pervasive and impairing among children in foster care but not a single prevention or intervention program for this fragile group targets sleep health. Poor sleep undermines effective self-regulation and stable biological rhythms, amplifying the negative impacts of early adversity/trauma on children's acute and long-term functioning. Consistent with evidence that optimizing sleep is critical for trauma recovery, we will adapt cognitive-behavioral treatment for pediatric insomnia, an efficacious intervention for various clinical and non-clinical child populations, for home-based delivery among children recently placed in a new foster home and evaluate initial efficacy, feasibility and target engagement.

PI_NAMEs: ALFANO, CANDICE A (contact)

PROGRAM_OFFICER_NAME: ROONEY, MARY

PROJECT_TERMS: 10 year old;acceptability and feasibility;Acute;Adult;Aftercare;Age;Anxiety;Arousal;Behavior;Behavioral;behavioral health;biobehavior;biological adaptation to stress;Biological Rhythm;Brain;care systems;Caregivers;Caring;Child;Child Abuse and Neglect;Child Rearing;Child Welfare;Childhood;circadian;Clinical;Cognitive Therapy;Development;Diagnostic;Disease;Early Intervention;early life adversity;effectiveness trial;efficacious intervention;Emotional;Environment;Evaluation;evidence base;Exhibits;expectation;experimental group;Family;Feedback;follow-up;foster care;foster home;Foster Home Care;Fostering;Foundations;Goals;Growth;high risk population;Home;Home environment;Hydrocortisone;Hypothalamic structure;Impairment;improved;Infant;Informal Social Control;Intervention;intervention program;Intervention Studies;Learning;Life;Literature;maltreatment;Manuals;Measurable;Measures;Mediating;Mediation;Mediator;Mental Health;neglect;Outcome;Pattern;Phase;physical conditioning;pilot test;Pituitary Gland;Policies;poor sleep;Population;prevent;Prevention;Prevention program;preventive intervention;Problem behavior;Procedures;programs;Protocols documentation;Randomized, Controlled Trials;Recording of previous events;Regulation;Reporting;Research;respiratory;School-Age Population;Severities;Sinus Arrhythmia;Sleep;Sleep Disorders;Sleep disturbances;sleep health;sleep quality;Sleeplessness;System;Testing;Time;Training;Trauma;trauma exposure;Trauma recovery;Waiting Lists

PROJECT_TITLE: B-SAFE: A Trauma-Informed Early Intervention Targeting Sleep and Adjustment Among Children in Foster Care


NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Narrative Bacillus cereus, a spore-forming, gram-positive bacterium, is a human pathogen commonly associated with hospital infections, foodborne outbreaks, and deaths. These serious health effects are mediated, in part, by a toxin produced by the bacteria. Here, we propose to identify how this toxin targets cells by discovering the heretofore-unknown cell surface receptor for the toxins. This work describes a new unbiased approach to study pore-forming toxins, potentially identifying common mechanisms used by other pathogenic bacteria, as well as providing a strategy to develop new therapies.

PI_NAMEs: LIU, SHIHUI  (contact)

PROGRAM_OFFICER_NAME: BAQAR, SHAHIDA

PROJECT_TERMS: Acute;Address;Animal Experiments;Anthrax disease;Bacillus cereus;Bacteria;Binding;Blindness;Cell Separation;Cell Surface Receptors;cell type;Cells;Cessation of life;Child;Clinical Management;Clustered Regularly Interspaced Short Palindromic Repeats;Complement;CRISPR screen;CRISPR/Cas technology;Cultured Cells;Cytolysis;cytotoxicity;Data;deep sequencing;Development;effective therapy;Endophthalmitis;expectation;foodborne outbreak;Genes;genome-wide;Gram-Positive Bacteria;Health;Hemolysin;Histology;Human;human pathogen;Immunocompetent;Immunocompromised Host;In Vitro;in vivo;Infection;Integration Host Factors;Investigation;Investigational Therapies;Knock-out;Knockout Mice;Knowledge;Libraries;Link;Lipopolysaccharides;Macrophage;Mediating;Molecular;mouse model;Mus;Mutagenesis;nanomolar;Nosocomial Infections;novel therapeutics;pathogen;Pathogenesis;pathogenic bacteria;Patients;Pneumonia;Proteins;rapid diagnosis;receptor;Receptor Gene;Reporting;Reproduction spores;Resistance;restoration;Role;screening;Targeted Toxins;targeted treatment;Testing;Therapeutic;therapeutically effective;Tissues;TNF gene;Toxin;Transgenic Mice;Virulence;Virulence Factors;whole genome;Work

PROJECT_TITLE: Defining cellular receptors for the Bacillus cereus hemolysin BL toxin (HBL) and the development of anti-HBL therapies

STUDY_SECTION: HIBP

STUDY_SECTION_NAME: Host Interactions with Bacterial Pathogens Study Section[HIBP]


ADMINISTERING_IC: LM

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Bioengineering;Cancer;Cardiovascular;Clinical Research;Data Science;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety

ORG_CITY: Los Angeles

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PI_NAMEs: SHAHABI, CYRUS  (contact)

PROGRAM_OFFICER_NAME: DENNIS, ALLISON FRANCES

PROJECT_TERMS: Abbreviations;Acceleration;Age;Ambulatory Monitoring;Apache;Apple watch;Area;Arrhythmia;Atrial Fibrillation;Behavioral;Big Data;Calories;Cancer Cluster;Cancer Patient;Cellular Phone;Characteristics;Clinic;Clinical;clinical care;Clinical Data;Clinical Trials;Clinics and Hospitals;cluster computing;Collaborations;Communities;Community Health;Computer software;Contact Tracing;Controlled Environment;COVID-19 pandemic;Custom;Data;data management;data streams;deep learning;design;Detection;Devices;Diagnosis;Diagnostic;Disease;distributed data;distributed memory;Drug Delivery Systems;Early identification;Effectiveness;Electrocardiogram;Emergency response;empowerment;Encapsulated;Ensure;Environment;Environmental Health;Epilepsy;Evaluation;Evolution;Expenditure;falls;fitbit;fitness;glucose monitor;Goals;Growth;Health;health application;health care model;health data;Health Professional;Heart Diseases;Home;Home Care Services;Hospitals;Hour;Impairment;improved;improved outcome;indexing;Individual;infancy;Infant;infant monitoring;insight;Intervention;Knowledge;Leg;Life;Location;Malignant Neoplasms;Measurable;Measurement;Medical;mHealth;Mind;mobile sensor;Modeling;Monitor;Movement;Names;open source tool;Outcome;Parkinson Disease;Patient Care;Patient Monitoring;Patients;Performance;Performance Status;Persons;Phase;Play;Quality of life;Recording of previous events;Research;Research Personnel;resilience;Rest;Risk;Role;SARS-CoV-2 transmission;Scientist;search engine;sensor;Series;Serious Adverse Event;Sleep Disorders;social;social media;Source;spatiotemporal;standard of care;Stream;Stroke;Symptoms;synthetic data;Technology;Testing;Time;time use;Training;trend;United States National Institutes of Health;Visit;wearable data;wearable device;wearable sensor technology;Work

PROJECT_TITLE: SCH: Wearables for Health and Disease Knowledge (W4H)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-VH-N(50)R]


ORG_CITY: SYRACUSE

ORG_DEPT: CHEMISTRY

ORG_NAME: SYRACUSE UNIVERSITY

PHR: PROJECT NARRATIVE: In cells, proteins condense to form dynamic, functional, liquid-like membraneless compartments, especially during times of stress. The regulation of how these compartments are assembled, disassembled, and maintain liquidity is not well-understood. In this proposal, we will determine how UBQLN2 and its interactions with other members of the protein quality control system contribute to regulation of membraneless compartments, and how dysregulation leads to disease states.

PI_NAMEs: CASTANEDA, CARLOS ANTONIO (contact)

PROGRAM_OFFICER_NAME: CHO, THOMAS Y

PROJECT_TERMS: Affect;Age;Amyotrophic Lateral Sclerosis;aqueous;Autophagocytosis;Behavior;Binding;Biological;Biology;Biophysical Process;Cell Culture Techniques;Cell Physiology;Cells;Cellular Stress;Characteristics;Client;Cytoplasm;Cytoplasmic Inclusion;Degradation Pathway;deletion library;design;Disease;experimental study;Foundations;Genetic Transcription;Goals;Image;In Vitro;in vivo;intermolecular interaction;Length;Libraries;Link;Liquid substance;Maintenance;Mammalian Cell;Mediating;member;Membrane;Microscopy;Modeling;Molecular;Monitor;Morphology;multicatalytic endopeptidase complex;mutant;Mutation;Nature;Neurodegenerative Disorders;NMR Spectroscopy;Organelles;Pathway interactions;Phase;Phase Transition;Physical condensation;physical process;Physiological;Polyubiquitin;Process;Property;protein function;protein TDP-43;Proteins;proteostasis;Quality Control;receptor;receptor binding;reconstitution;recruit;Regulation;Research;response;RNA-Binding Proteins;Role;Signal Transduction;Signaling Protein;Solid;spatiotemporal;Stress;stress granule;superresolution microscopy;System;Tertiary Protein Structure;Therapeutic;Time;Ubiquitin

PROJECT_TITLE: The Role and Mechanisms of UBQLN2-mediated Phase Transitions in the Assembly and Disassembly of Biomolecular Condensates

STUDY_SECTION: MSFB

STUDY_SECTION_NAME: Macromolecular Structure and Function B Study Section[MSFB]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Comparative Effectiveness Research;Emergency Care;Health Services;Neurosciences;Patient Safety;Physical Injury - Accidents and Adverse Effects

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

PHR: The SIREN consortium will conduct multi-site clinical trials in the emergency department (ED) and emergency medical services (EMS) settings to improve the outcomes for patients with neurologic, cardiac, respiratory, hematologic, and trauma emergency events. Oregon Health & Science University has the institutional experience, study team leadership, and pre-existing ED / EMS research networks to continue leading a productive Oregon SIREN enrollment hub.

PI_NAMEs: DAYA, MOHAMUD RAMZANALI (contact);KEA, BORY

PROJECT_TERMS: Accident and Emergency department;Active Learning;acute care;Acute Lung Injury;Anesthesia procedures;Award;Cardiac;Cardiology;Cardiovascular system;Clinical;clinical trial analysis;Clinical Trials;Clinical Trials Network;Collaborations;Communicable Diseases;Communication;Contracts;Coronary;Critical Care;Data;design;Early treatment;Electric Countershock;Eligibility Determination;Emergency Care;Emergency medical service;Emergency Medicine;Emergency research;Emergency Situation;Enrollment;Ensure;Event;experience;Faculty;Funding;Geography;Goals;Grant;Health;Health Services Research;Hematology;Hospitals;improved outcome;Informed Consent;innovation;Institution;Institutional Review Boards;Investigation;Lead;Leadership;Learning;Link;Lung;meetings;member;Mentors;Methodology;Methods;Minority;Multi-Institutional Clinical Trial;multidisciplinary;National Heart, Lung, and Blood Institute;National Institute of Neurological Disorders and Stroke;Neurologic;Neurological emergencies;Neurology;neurosurgery;next generation;operation;Operative Surgical Procedures;Oregon;out-of-hospital cardiac arrest;Outcome;participant enrollment;patient population;Patient-Focused Outcomes;Patients;payment;pediatric emergency;Physicians;Positioning Attribute;Prevention;Principal Investigator;Productivity;recruit;Research;Research Personnel;Research Training;respiratory;Resuscitation;Science;Scientist;Service setting;Site;Structure;success;Training;Trauma;trauma care;treatment trial;United States;United States Agency for Healthcare Research and Quality;United States Health Resources and Services Administration;United States National Institutes of Health;Universities

PROJECT_TITLE: The OHSU SIREN Network Enrollment Hub Renewal


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Diabetes;Health Services;Maternal Health;Maternal Morbidity and Mortality;Nutrition;Obesity;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Women's Health Research

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE Women with a history of gestational diabetes mellitus (GDM) are at high risk of developing Type 2 diabetes. We are proposing a randomized controlled trial evaluating shared decision making for diabetes prevention among overweight/obese women with a history of GDM and hemoglobin A1c between 5.7-6.4%. The primary study outcome is loss of >5% of body weight, and secondary study outcomes include uptake of behavior change, use of metformin, and increased follow-up screening for diabetes.

PI_NAMEs: DURU, OBIDIUGWU KENRIK (contact);MOIN, TANNAZ

PROGRAM_OFFICER_NAME: CENTER, MAUREEN MONAGHAN

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;Adopted;Area;behavior change;Body Weight;Body Weight decreased;Case Manager;Clinic;Clinical;Communication;Cost Analysis;Decision Aid;Decision Making;Diabetes Mellitus;Diabetes prevention;diabetes prevention program;Eating;effectiveness testing;Equipoise;evidence base;experience;Face;Fatigue;follow-up;Gestational Diabetes;Glycosylated hemoglobin A;Health Benefit;Health Personnel;health related quality of life;Health system;Healthcare;Healthcare Systems;high risk;improved;Incidence;incremental cost;Infrastructure;Intervention;Life Style;lifestyle intervention;lifetime risk;Light;Metformin;multidisciplinary;Non-Insulin-Dependent Diabetes Mellitus;Obesity;Outcome;Outcome Study;Overweight;Participant;Patient Outcomes Assessments;Patient Preferences;Patients;Pattern;Pharmacists;Physical activity;pilot test;Population;Postpartum Period;Prediabetes syndrome;preference;Pregnancy;prevent;Prevention strategy;program costs;Provider;Publishing;Randomized, Controlled Trials;Recommendation;Recording of previous events;Reporting;Risk Factors;Role;screening;secondary outcome;shared decision making;Stress;success;Surveys;Therapeutic Equivalency;Time;tool;treatment as usual;uptake;Woman;women's prevention;Work

PROJECT_TITLE: A Shared Decision Making Intervention for Diabetes Prevention in Women with a History of Gestational Diabetes Mellitus.


NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Neurosciences;Pediatric

ORG_CITY: PULLMAN

ORG_NAME: WASHINGTON STATE UNIVERSITY

ORG_STATE: WA

PHR: This study is aimed at increasing our understanding of etiological factors associated with the most frequently occurring anxiety symptoms/disorders. Developmental shifts in fearful reactivity and the underlying neurophysiology will be examined via an intensive longitudinal design, elucidating change-related effects contributing to emergence of anxiety, and the influence of maternal sensitivity on these effects. Most salient predictors of early anxiety symptoms represent targets for preventative efforts.

PI_NAMEs: BELL, MARTHA ANN ;GARTSTEIN, MARIA A. (contact);JONES, NANCY AARON

PROGRAM_OFFICER_NAME: THOMAS, LAURA ANDERSON

PROJECT_TERMS: Acceleration;Address;Adult;Age Months;Amygdaloid structure;Anxiety;Anxiety Disorders;anxiety symptoms;anxious behavior;Apgar Score;Attenuated;Automobile Driving;Behavior;behavior observation;Behavioral;Behavioral inhibition;Behavioral Model;Birth;Buffers;Caregivers;Cerebral Dominance;Child;Childhood;Communities;Complex;computerized data processing;cost;Coupled;Coupling;Data Collection;Demographic Factors;design;Development;Disease;Electroencephalography;Electrophysiology (science);Enrollment;ethnic diversity;Etiology;Evaluation;Family Demographies;Foundations;Fright;Functional Magnetic Resonance Imaging;Gestational Age;Growth;Individual Differences;infancy;Infant;Interview;Jupiter;Laboratories;Left;Life;life span;Link;Location;longitudinal design;maternal depression;Measures;Medical;Methods;Modeling;Mothers;Negative Valence;neurophysiology;parenting intervention;Parents;Pattern;Play;Preventive;Psychopathology;Psychophysiology;Questionnaires;Race;racial diversity;recruit;Reporting;Research;Research Domain Criteria;Resources;Risk;Role;Sampling;Services;Shapes;Site;socioeconomics;Structure;Symptoms;Temperament;Testing;therapeutic target;Time;Translating;transmission process;Universities;Weight

PROJECT_TITLE: Precursors of Anxiety: The Role of Lateralized Brain Activation and Maternal Sensitivity

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


ADMINISTERING_IC: AG

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Pediatric;Post-Traumatic Stress Disorder (PTSD);Social Determinants of Health

ORG_CITY: BLOOMINGTON

ORG_NAME: TRUSTEES OF INDIANA UNIVERSITY

ORG_STATE: IN

PHR: PROJECT NARRATIVE This project seeks to pilot test the feasibility, acceptability, and efficacy of using the elephant as a model for understanding the relationship between early life trauma and aging-related morbidities. The overarching goal of this career development award is to foster the advancement of Daniella Chusyd, PhD into an independent researcher focused on elucidating factors that contribute to the variation in the rate of aging.

PI_NAMEs: CHUSYD, DANIELLA E. (contact)

PROGRAM_OFFICER_NAME: GERALD, MELISSA S

PROJECT_TERMS: Address;Adult;adverse childhood events;affiliative behavior;Age;age acceleration;Aging;aging related;allostasis;allostatic load;Animal Model;antisocial behavior;Applications Grants;Area;Autoimmune Diseases;Award;Awareness;Behavior;behavioral health;Biological;biological adaptation to stress;biological age;career development;Caring;Child;Childhood;Chronology;Cognition;cognitive function;cognitive task;Conflict (Psychology);design;Development;Diabetes Mellitus;Disease;Disease Progression;Disease susceptibility;Doctor of Philosophy;Dose;early life exposure;Early-life trauma;Education;Effectiveness;Elephants;Emotional;Endocrine system;Endocrinology;Environment;Ethics;Ethnic Origin;Excision;Exercise;experience;experimental study;Exposure to;Family;Family member;feasibility testing;Food;Fostering;Genetic;Goals;Hand;Health;healthy aging;Heart Diseases;Human;Immune system;improved;Individual;information gathering;innovation;insight;Intelligence;inter-individual variation;Interruption;Intervention;K-Series Research Career Programs;Lead;Learning;Life;Life Expectancy;life history;life span;Malignant Neoplasms;Memory;Mentorship;Methods;Modeling;Morbidity - disease rate;mortality;Mothers;Natural experiment;Nervous System;Non-Insulin-Dependent Diabetes Mellitus;Obesity;Orphan;Orphanages;Outcome;Parasites;Parents;Persons;Physiological;pilot test;poor health outcome;Population;Post-Traumatic Stress Disorders;Predisposition;Prevalence;Property;psychobiology;psychologic;Public Health;Randomized;rate of aging;Research;Research Personnel;response;Risk;Sampling;Science;Scientist;sex;skills;Smoking;social;social health determinants;social learning;social norm;Socioeconomic Status;Source;standard care;stressor;Stroke;System;Ticks;Time;TP53 gene;Training;Training Activity;trait;Trauma;Variant;Water;Work;Zambia

PROJECT_TITLE: Early life trauma and aging using a long-lived animal model

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development For Early Career Investigators Study Section [AGCD-2]


NIH_SPENDING_CATS: American Indian or Alaska Native;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research

ORG_CITY: LAWRENCE

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF KANSAS LAWRENCE

ORG_STATE: KS

PHR: NARRATIVE The proposed project will increase the diversity of the scientific community by preparing American Indians and other underrepresented students for graduate study and eventual careers in biomedical research. Because of the breadth of disciplines, the project will increase interest from a wide range of perspectives in research regarding diseases with a high incidence in minority populations, improving both health care and disease prevention in this country.

PI_NAMEs: BLANCO, V GUSTAVO (contact);SMITH, ADAM STEVEN;VAKSER, ILYA

PROGRAM_OFFICER_NAME: STEPANEK, LAURIE ELIZABETH

PROJECT_TERMS: Address;American;American Indians;Biomedical Research;career;Classification;Collaborations;Communication;Communities;Competence;Computer Analysis;Country;Data Analyses;Development;Development Plans;Discipline;Disease;disorder prevention;Doctor of Philosophy;education research;Enrollment;Evaluation;experience;Faculty;Foundations;Goals;Graduate Degree;graduate student;Healthcare;improved;Incidence;Individual;innovation;Institution;interest;Journals;Kansas;Laboratories;Literature;Measurable;member;Mentors;Minority Groups;Oral;peer;Personal Satisfaction;Play;Positioning Attribute;Postbaccalaureate;Program Evaluation;programs;promote resilience;Qualifying;recruit;Reproducibility;Research;Research Activity;Research Project Grants;Research Training;Rewards;Science;Scientist;Self Efficacy;Series;Shapes;skill acquisition;skills;STEM field;student mentoring;Students;success;support network;symposium;Testing;Training;Underrepresented Populations;Underrepresented Students;Universities;Work;Writing

PROJECT_TITLE: KU Post-Baccalaureate Research Education Program


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Diabetes;Digestive Diseases;Kidney Disease;Liver Disease;Nutrition;Obesity

ORG_CITY: WYNNEWOOD

ORG_NAME: LANKENAU INSTITUTE FOR MEDICAL RESEARCH

PHR: Narrative This research proposal responds to the challenge of improving scientific understanding of the cellular processes that lead to diabetes complications. Our objective is to demonstrate that a cause in diabetes complications that has been overlooked by diabetes researchers is intracellular 3-deoxyglucosone, a toxic metabolite generated by the fructosamine-3-kinase (FN3K) enzyme pathway. The project also aims to identify a selective and potent inhibitor of the FN3K pathway for further drug development as a new treatment modality for diabetes complications.

PI_NAMEs: PRENDERGAST, GEORGE C (contact);REICHMAN, MELVIN

PROGRAM_OFFICER_NAME: LI, YAN

PROJECT_TERMS: absorption;Acceleration;Acute;acute toxicity;Address;Advanced Glycosylation End Products;Amino Sugars;antagonist;Anti-diabetic Drugs;Autoimmune;Automobile Driving;Biological Markers;Blood Vessels;Cardiovascular system;catalyst;Cell Physiology;Cells;Chronic;Clinical Management;clinically relevant;Complex;Complications of Diabetes Mellitus;Consumption;cost;Coupled;crosslink;Data;Development;Diabetes Mellitus;diabetes pathogenesis;Diabetic mouse;Diabetic Nephropathy;Diet;DNA;drug development;Elements;Enzyme Inhibitor Drugs;enzyme pathway;Enzymes;Epitopes;Etiology;Event;extracellular;Fatty Liver;Food;Fructosamine;glycation;Healthcare Systems;Heart;Hyperglycemia;improved;Inflammatory;Ingestion;inhibitor;innovation;insight;Kidney;Kidney Diseases;Kidney Failure;Knowledge;lead candidate;Liver;Macrophage;Maillard Reaction;Measures;Mediating;medication safety;Medicine;Meglumine;Metabolic syndrome;Methodology;Methods;Modality;Monitor;mouse model;Mus;new therapeutic target;non-alcoholic fatty liver disease;Non-Insulin-Dependent Diabetes Mellitus;nutrition;Obesity;Outcome;Pathogenesis;Pathogenicity;Pathway interactions;Patients;Pharmaceutical Preparations;Pharmacodynamics;Phosphotransferases;population health;Preclinical Drug Development;Prediabetes syndrome;prevent;Process;Prognostic Marker;programs;Property;Proteins;Published Comment;Publishing;receptor;repaired;Research;Research Personnel;Research Proposals;Role;Series;Serum;Stress;Structural Protein;Structure-Activity Relationship;therapeutic development;Therapeutic Intervention;Time;time interval;Tissues;tool;Toxic effect;Translational Research;Triglycerides;Unhealthy Diet;Vulnerable Populations;Weaning;western diet;Work

PROJECT_TITLE: Probing an Unexplored Intracellular Pathway in Diabetes Pathogenesis

STUDY_SECTION: CSME

STUDY_SECTION_NAME: Cell Signaling and Molecular Endocrinology Study Section[CSME]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Post-Traumatic Stress Disorder (PTSD);Violence Against Women;Violence Research;Women's Health Research

ORG_CITY: LEXINGTON

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: The proposed project will address critical gaps in current knowledge regarding the experience and management of posttraumatic shame – an emotion consistently implicated in the development, maintenance, and/or worsening of PTSD symptoms among women with a history of sexual or physical assault or abuse (i.e., interpersonal trauma). Existing treatments for PTSD often fail to fully address posttraumatic shame, and untreated shame represents an ongoing risk factor for the development or worsening of PTSD symptoms. Findings from this study hold promise for improving treatment efforts for shame and PTSD by clarifying aspects of how women experience and manage shame after interpersonal trauma.

PI_NAMEs: TIPSWORD, JORDYN M (contact)

PROGRAM_OFFICER_NAME: AVENILLA, FRANK R

PROJECT_TERMS: Address;Attitude;career;Data;Data Collection;design;Development;distraction;Ecological momentary assessment;Effectiveness;emotion regulation;Emotional;Emotions;experience;Extramural Activities;Feeling;Frequencies;Funding;Goals;Grant;Guilt;improved;Individual;insight;interpersonal trauma;Intervention Studies;Interview;Knowledge;Life;Literature;Lived experience;Maintenance;Memory;Methods;Modeling;Morals;novel;Participant;Persons;physical assault;Physiological;Post-Traumatic Stress Disorders;Process;prospective;Qualitative Methods;Recording of previous events;Recovery;Regulation;Research;Research Personnel;response;Risk;Risk Factors;Role;rumination;secondary analysis;Secondary to;Severities;sexual assault;Shame;Shapes;stem;Symptoms;Testing;Time;Training;trait;Trauma;traumatic event;United States;Withdrawal;Woman;women's treatment;Work

PROJECT_TITLE: The Experience and Regulation of Posttraumatic Shame among Women with Histories of Interpersonal Trauma

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F16-L(20)L]


NIH_SPENDING_CATS: Aging;Neurodegenerative;Neurosciences

ORG_CITY: HANOVER

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: Project Narrative  The myelin sheath is a crucial component in maintaining proper neuronal communication in the brain. The degeneration and failure to remove the myelin sheath is a common pathology that occurs in many neurodegenerative diseases however it is unclear how this clearance process fails. This proposal will investigate the dynamics in which microglia respond to myelin debris and how failure to remove it inhibits the remyelination process, providing insight into why this repair process fails in late stages of disease and aging.

PI_NAMEs: OLVEDA, GENARO  (contact)

PROGRAM_OFFICER_NAME: TYLER, WILLIAM A

PROJECT_TERMS: Action Potentials;Address;Adult;Affect;age effect;age related;Aging;Agonist;Alzheimer's Disease;Amyotrophic Lateral Sclerosis;Apoptotic;Axon;Brain;career;Cell Physiology;Cells;Central Nervous System;Cessation of life;Cholesterol;Chronic;cognitive function;Communication;Community Outreach;Complex;CSPG4 gene;Data;Demyelinations;Detection;Development;Disease;Disease Progression;DNA Damage;Environment;Etiology;Excision;experimental study;Faculty;Failure;Fluorescence;Functional disorder;Generations;Genetic;Goals;high resolution imaging;Image;in vivo;in vivo imaging;Induction of Apoptosis;insight;Knockout Mice;Knowledge;Label;Lasers;Liver X Receptor;Maintenance;Mediating;Medical center;Mentorship;Methods;Microglia;Modeling;Monitor;Multiple Sclerosis;Mus;Myelin;myelin degeneration;Myelin Sheath;Names;Natural regeneration;Nerve Degeneration;Neurodegenerative Disorders;Neuroglia;Neurons;Neurosciences;novel;old mice;Oligodendroglia;Operative Surgical Procedures;optical imaging;Pathology;Pathway interactions;Phagocytes;Phagocytosis;pharmacologic;Population;Preparation;Process;Production;Proliferating;receptor;remyelination;repaired;Reporting;Research Design;Research Personnel;Resolution;Resources;response;serial imaging;spatiotemporal;Specificity;Speed;stem cells;Structure;targeted treatment;Techniques;Testing;Time;tissue repair;tool;Training;training opportunity;Transgenic Mice;transmission process;Work

PROJECT_TITLE: The Effects of Aging and Microglia Dysfunction on Remyelination


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Genetics;Human Genome;Mental Health;Mental Illness;Precision Medicine;Prevention;Substance Misuse

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative Individuals with an alcohol use disorder are more likely to exhibit other psychiatric or medical disorders, complicating access to, and the effectiveness of, different treatments. This proposal will investigate the genetic contribution of alcohol use disorder to risk of other disorders by studying an ethnically diverse sample, and integrating additional information from biological pathways and environmental measures to provide insight into the etiologic pathways underlying these disorders. The proposed project will provide a foundation for future studies that would allow stratification of individuals into personalized treatment programs based on their disease etiology, along with the promise of early identification of at-risk individuals to target with prevention strategies.

PI_NAMEs: KEMBER, RACHEL LORRAINE (contact)

PROGRAM_OFFICER_NAME: GITIK, MIRI

PROJECT_TERMS: accurate diagnosis;addiction;Adverse effects;Affect;African ancestry;Age;alcohol abuse therapy;Alcohol consumption;alcohol exposure;alcohol use disorder;Alcoholism;Alcohols;Anxiety Disorders;Biological;Biological Process;Cardiovascular Diseases;career;Categories;childhood adversity;Clinical;comorbidity;Complex;Consumption;Data;Data Set;design;Development;Diabetes Mellitus;Diagnosis;Diagnostic;Disease;disorder risk;drinking;Drug Addiction;Early identification;Effectiveness;Environment;Environmental Exposure;Environmental Risk Factor;Epidemiologic Methods;ethnic diversity;Etiology;European ancestry;Exhibits;Exposure to;Foundations;Funding;Future;Gastrointestinal Diseases;gene environment interaction;Genetic;genetic analysis;genetic epidemiology;Genetic Heterogeneity;Genetic Models;Genetic Risk;genetic variant;genome wide association study;genome-wide;Genomics;Goals;Gout;Height;Heterogeneity;Individual;innovation;insight;Intervention;Interview;K-Series Research Career Programs;Knowledge;Lipids;Lung Diseases;Measures;Medical;Medical Genetics;Mental disorders;Methods;Mood Disorders;Pathway interactions;personalized medicine;phenome;phenomenological models;Phenotype;phenotypic data;pleiotropism;polygenic risk score;Population;prevent;Prevention strategy;psychiatric comorbidity;Records;Reporting;Research;Research Activity;Research Personnel;Resources;Risk;Risk Marker;risk prediction;risk prediction model;risk variant;Role;Sampling;Schedule;Schizophrenia;Severities;skill acquisition;skills;social;Social Behavior;Stratification;Structure;Subgroup;Substance Use Disorder;Testing;Tissues;Training;Training Activity;Training Programs;trait;Translations;trauma exposure;treatment program;United States

PROJECT_TITLE: Characterizing the phenotypic spectrum associated with genetic liability for alcohol use disorder

STUDY_SECTION: AA

STUDY_SECTION_NAME: Epidemiology, Prevention and Behavior Research Study Section[AA-2]


ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative Epithelial-mesenchymal crosstalk tightly regulates the balance between cell proliferation and differentiation to sustain the frequent cellular turnover needs of the mammalian small intestine. While mesenchymal cells, particularly fibroblasts, function to support stem cells, fibroblasts have unexpected pathogenic roles that drive uncontrolled epithelial growth in intestinal polyp formation. This project is relevant to public health as it will reveal the underlying fibroblast-driven mechanisms in polyp formation and deepen our foundational knowledge on dysregulated epithelial-fibroblast crosstalk in disease initiation, which could ultimately lead to the identification of novel target cell types in preventing/treating intestinal cancer and other fibroblast-mediating diseases.

PI_NAMEs: LI, MEI LAN  (contact)

PROGRAM_OFFICER_NAME: DENSMORE, CHRISTINE L

PROJECT_TERMS: Acute;Adolescent;Agonist;antagonist;Architecture;Biology;carcinogenesis;Cell Differentiation process;Cell Proliferation;cell type;Cells;Choristoma;Collaborations;confocal imaging;Data;Disease;Epithelial Cells;epithelial stem cell;Epithelium;Equilibrium;Event;Fibroblasts;Fluorescent in Situ Hybridization;gastrointestinal;Gene Expression Profile;Germ-Line Mutation;Goals;Growth;Heterogeneity;Homeostasis;Inherited;insight;Intestinal Cancer;intestinal epithelium;intestinal homeostasis;Intestinal Polyposis;Intestinal Polyps;Intestines;Juvenile polyposis syndrome;Knowledge;Lead;Ligands;Link;loss of function;Maintenance;Measures;Mediating;Mesenchymal;Modeling;mouse model;Mus;Muscle;novel;overexpression;Pathogenesis;Pathogenicity;Pattern;polyposis;Polyps;Population;prevent;Proliferating;Public Health;Regulation;Reporter;Reporting;Risk;Role;segregation;Shapes;Signal Transduction;single molecule;Small Intestines;smoothened signaling pathway;Spatial Distribution;Specific qualifier value;stem cell niche;stem cell proliferation;stem cells;stemness;Syndrome;System;Testing;Tissues;transcriptomics;Universities;Villus;WNT Signaling Pathway

PROJECT_TITLE: Epithelial-mesenchymal crosstalk in intestinal polyp formation


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Mental Health;Mental Illness;Neurosciences

ORG_CITY: Minneapolis

ORG_NAME: HABITAWARE, INC.

ORG_STATE: MN

PHR: Narrative Trichotillomania severely impairs social, physical and mental well-being. Patient access to evidence-based treatments (EBTs) such as self-monitoring, stimulus control and Habit Reversal Training (HRT) is extremely limited due to a lack of trained providers and patients’ lack of willingness to seek treatment due to shame and privacy. We seek to increase the potency of EBTs and access to EBTs for TTM patients by developing a wearable device and mobile app system that passively detects a patient’s TTM episodes, creating an episode history with additional contextual information, and helps the patient reduce hair pulling with both predictive and real-time EBT reminders.

PI_NAMEs: FLESSNER, CHRISTOPHER A.;KUMAR, SAMEER  (contact)

PROGRAM_OFFICER_NAME: GRABB, MARGARET CHRISTINE

PROJECT_TERMS: active control;adaptive intervention;Address;Affect;Algorithms;Area;Awareness;Behavior;Behavior Therapy;Caring;Categories;Characteristics;Clinical;clinical efficacy;commercialization;comparison control;contextual factors;cost;Crowding;Data;data portal;design;Detection;Devices;Directories;Ecological momentary assessment;efficacy testing;Elements;Ensure;evidence base;Evidence based treatment;Feasibility Studies;Feedback;Focus Groups;Frequencies;Future;Goals;Guilt;Habits;Hair;Health Personnel;Health system;Impairment;improved;improved outcome;Libraries;Literature;Location;Manuals;meetings;Mental disorders;Mental Health;mobile application;Modeling;Monitor;Motion;National Institute of Mental Health;novel;Occupational;Participant;Patients;Pattern;Persons;Phase;phase 1 study;pilot trial;Predictive Analytics;predictive modeling;Price;Privacy;Process;Provider;provider portal;psychologic;Quality of life;Questionnaires;randomized trial;Recording of previous events;recruit;reduce symptoms;Relapse;Reporting;response;Severities;Shame;Small Business Innovation Research Grant;social;Social isolation;Source;Stimulus;Strategic Planning;success;Symptoms;System;Technology;Testing;Therapeutic;Thinness;Time;Training;Trichotillomania;Update;wearable device;Well in self;willingness;Work

PROJECT_TITLE: Technology Assisted Treatment for Trichotillomania


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: REDLANDS

ORG_NAME: LOMA LINDA VETERANS ASSN RESEARCH & EDUC

PHR: Project Narrative The current obesity rate of 39 percent is anticipated to climb to 55 percent by year 2045 in the United States. Since obesity is becoming a prevalent and destructive health disorder linked to some of the leading causes of preventable death including type 2 diabetes (T2DM) and osteoporosis, there is an urgent need to understand the molecular pathways driving the pathogenesis of obesity-related disorders such as T2DM and osteoporosis. Based on our novel discovery that disruption of Kinase Suppressor of Ras (Ksr) 2, a gene recently implicated in obesity and T2DM, leads to a dramatic increase in trabecular bone mass, our proposed efforts in this grant application will delineate the mechanisms by which this obesity gene regulates the skeletal phenotype. The long-term goal of this proposal is to identify novel therapeutic approaches for prevention and treatment of fractures in obesity/T2DM-related conditions, thereby reducing the burden of these chronic diseases both on individuals and on society.

PI_NAMEs: MOHAN, SUBBURAMAN  (contact)

PROGRAM_OFFICER_NAME: NICKS, KRISTY

PROJECT_TERMS: Adipocytes;Adipose tissue;Adult;Affect;Age Months;aging population;Animal Model;Applications Grants;Automobile Driving;Basal metabolic rate;Biochemical;Body fat;Body Weight;bone;Bone Density;bone epiphysis;Bone Formation Stimulation;bone health;Bone Marrow;bone mass;bone metabolism;Breeding;burden of chronic illness;Cardiovascular Diseases;Cell Lineage;Cells;Characteristics;Chemicals;Clinical Data;Code;Complex;conditional knockout;cost;Data;diabetic;Disease;Distal;Drug Targeting;early-onset obesity;energy balance;Energy Intake;Energy Metabolism;Exhibits;Fatty acid glycerol esters;feeding;Feeding behaviors;Female;Femur;Fracture;fracture risk;Funding;Gene Expression;General Population;Generations;Genes;genome wide association study;Goals;Health;HIF1A gene;Histology;Hormone Responsive;Human;Hypothalamic structure;Hypoxia;Immunohistochemistry;improved;in vivo;Individual;inhibitor;Insulin Resistance;knock-down;Knock-out;Knockout Mice;KSR gene;Link;lipid metabolism;long bone;LoxP-flanked allele;Malignant Neoplasms;MAP Kinase Gene;Mechanics;Mediating;MEKs;Metabolic;Metabolic Diseases;Metaphysis;microCT;Modeling;Molecular;Morbidity - disease rate;mTOR protein;Mus;Mutate;Mutation;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutic intervention;obese person;Obesity;old mice;Orthologous Gene;osteoblast differentiation;Osteoblasts;Osteogenesis;osteogenic;Osteoporosis;osteoporosis with pathological fracture;Pathogenesis;Pathway interactions;Patients;Phenotype;Phosphorylation;Phosphotransferases;Physiologic Ossification;Physiological;Physiology;precursor cell;Prevalence;preventable death;Prevention approach;Proliferating;Proteins;Public Health;Publishing;ras Proteins;Ras/Raf;Regulation;Reverse Transcriptase Polymerase Chain Reaction;Risk Factors;Role;scaffold;Scaffolding Protein;Signal Pathway;Signal Transduction;skeletal;Societies;Study models;substantia spongiosa;Susceptibility Gene;Testing;Therapeutic;Thyroid Hormone Receptor;Thyroid Hormones;Time;United States;Variant;Western Blotting

PROJECT_TITLE: Role and Mechanism of Action of Ksr2, an Obesity and Type 2 Diabetes Gene, in Bone Metabolism

STUDY_SECTION: SBDD

STUDY_SECTION_NAME: Skeletal Biology Development and Disease Study Section[SBDD]


ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: PROJECT NARRATIVE  Expedient access to new treatments for human disease is predicated on synthetic strategies that can access diverse families of organic compounds for evaluation. This proposal comprises a method for the controlled editing of carbon-hydrogen bonds within compounds that have the potential for treating human diseases, relying specifically on the aspects of their structure that typically present challenges for existing methods. Utilizing newly designed catalysts and reagents, modification can be targeted to particular carbon- hydrogen bonds, and numerous new functional groups can be introduced from a single precursor.

PI_NAMEs: D'ANGELO, KYAN ANTHONY (contact)

PROGRAM_OFFICER_NAME: JONES, LATAISIA CHERIE

PROJECT_TITLE: Catalyst- and Reagent-Guided Selective Alkyl C-H Bond Functionalization


NIH_SPENDING_CATS: Aging;Bioengineering;Biotechnology;Neurosciences;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: ATLANTA

ORG_DEPT: ORTHOPEDICS

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Public Health Relevance Statement: Aging muscle exhibits significant deficits in repair capacity. While exposure to a young systemic environment is shown to rejuvenate muscle regenerative capacity, reliable identification of these humoral youthful factors responsible for this effect remains challenging. The proposed work will provide an innovative approach to develop a biomimetic model system for more accurate and cost-effective identification of anti-aging factors.

PI_NAMEs: JANG, YOUNG CHARLES (contact)

PROGRAM_OFFICER_NAME: COGLIATI, TIZIANA PAOLA

PROJECT_TERMS: 3-Dimensional;Address;age related;age-related disease;Aging;animal old age;anti aging;Biochemical;Biological Models;Biomedical Engineering;Biomimetics;Blood;Blood - brain barrier anatomy;Brain;cell age;Cell Physiology;cell type;Cells;Characteristics;Circulation;Clinical;Coculture Techniques;cost effective;Cues;Data;Death Rate;Development;Endocrine Glands;Engineering;Environment;Exercise;Exhibits;Exposure to;genetic approach;Geroscience;Goals;hallmarks of aging;Human;human old age (65+);Image;In Vitro;in vitro Model;in vivo;innovation;Investigation;juvenile animal;Label;Mechanics;Mediating;Microcirculation;Microfabrication;Microfluidics;microphysiology system;minimally invasive;Modeling;mouse model;Muscle;muscle aging;Muscle Contraction;Muscle function;muscle progenitor cell;Muscle satellite cell;Muscular Atrophy;myogenesis;Natural regeneration;Nature;Neuromuscular Junction;novel;Operative Surgical Procedures;Optics;optogenetics;Organ;Outcome;Oxidative Stress;Oxidative Stress Induction;Parabiosis;Patients;Physiological;Plasma;Property;Proteins;Proteome;Proteomics;public health relevance;Regenerative capacity;Rejuvenation;repaired;Reporter;Serum;Skeletal Muscle;stem;stem cell function;System;Testing;Transgenes;Translating;Validation;Vascularization;Work

PROJECT_TITLE: Engineered Heterochronic Parabiosis on 3D Microphysiological Systems


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Mental Health;Women's Health Research

ORG_CITY: AUSTIN

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

PHR: Project Narrative This project assesses how married partners affect one another’s health behaviors, mental health, and physical health over an 8-year period and how those processes vary across gay, lesbian, and heterosexual marriages. Findings from this project will inform research and policy involving how marriage influences health for different types of marital unions.

PI_NAMEs: UMBERSON, DEBRA J. (contact)

PROJECT_TERMS: Affect;Age;age related;Aging;Alcohol consumption;American;Baseline Surveys;Behavior;Behavioral;Biological;caregiving;Couples;Data;Data Analyses;Data Collection;Data Set;diaries;Distress;emotion regulation;Emotional;evidence base;experience;Exploratory/Developmental Grant;follow-up;Gays;Gender;gender difference;Gender Relations;Goals;Health;Health behavior;health difference;Health Status;Heterosexuals;Individual;innovation;Knowledge;late life;Lead;Legal;Lesbian;Link;Long-Term Effects;longitudinal design;Marriage;Mediating;men;Mental Depression;Mental Health;middle age;novel;Obesity;Outcome;Pathway interactions;Pattern;peer;Personal Satisfaction;physical conditioning;physical symptom;Policies;Population Research;Process;Productivity;psychologic;psychological symptom;Publications;Recording of previous events;Research;resilience;response;Risk;Same-sex;same-sex partnership;Scientific Advances and Accomplishments;Scientist;sex;Shapes;social;Spouses;Stress;Surveys;Thinking;Time;transmission process;Unmarried;Variant;Woman

PROJECT_TITLE: How Spouses Influence Each Other's Health in Same- and Different-Sex Marriages: A Dyadic and Longitudinal Assessment from Mid to Later Life

STUDY_SECTION: SSPA

STUDY_SECTION_NAME: Social Sciences and Population Studies A Study Section[SSPA]


NIH_SPENDING_CATS: Aging;Genetics;Osteoporosis;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: LITTLE ROCK

ORG_NAME: UNIV OF ARKANSAS FOR MED SCIS

ORG_STATE: AR

PHR: PROJECT NARRATIVE Loss of bone mass is one of the most common features of human aging, but the mechanisms responsible for this effect remain unknown. The aim of the work proposed in this application is to identify the means by which aging causes bone loss by studying senescence of the bone-forming cells. Knowledge gained with these studies may prove useful for the development of therapies that can treat osteoporosis.

PI_NAMEs: ALMEIDA, MARIA JOSE (contact);O'BRIEN, CHARLES A

PROGRAM_OFFICER_NAME: WILLIAMS, JOHN

PROJECT_TERMS: Adipocytes;Age;age related;age related decline;Age-Related Bone Loss;age-related disease;aged;Aging;aging mechanism;Apoptosis;Attenuated;bone;bone loss;Bone Marrow;bone mass;Bone remodeling;Bone Resorption;CDKN1A gene;CDKN2A gene;Cell Aging;Cell Cycle Arrest;Cell Cycle Regulation;Cell Lineage;cell type;Cells;cortical bone;cytokine;Disease;DNA Damage;Exhibits;Fracture;fragility fracture;functional decline;GATA4 gene;Human;human old age (65+);In Vitro;Inflammatory;inhibitor;Knowledge;Label;Laboratories;long bone;loss of function;men;Molecular;Mus;NF-kappa B;old mice;Organ Culture Techniques;Osteoblasts;Osteocytes;Osteogenesis;Osteoporosis;osteoprogenitor cell;overexpression;Oxidative Stress Induction;Pathway interactions;pharmacologic;Phenotype;Porosity;prevent;Production;progenitor;red fluorescent protein;Resistance;response;senescence;senescence associated secretory phenotype;senescent cell;senolytics;skeletal;Skeleton;SOD2 gene;substantia spongiosa;Testing;therapy development;Thinness;Time;tissue stem cells;Tissues;TNFSF11 gene;TP53 gene;Transgenes;Transgenic Organisms;Up-Regulation;Vertebral column;Woman;Work;young adult

PROJECT_TITLE: Different consequences of cellular aging in cortical versus cancellous bone- Resubmission


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cardiovascular;Cerebrovascular;Dementia;Neurodegenerative;Neurosciences;Osteoporosis;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: PUBLIC HEALTH RELEVANCE STATEMENT (NARRATIVE) Increasing clinical evidence suggests an association between bone metabolism and age-associated vascular events, particularly cardiovascular and cerebrovascular diseases. Our goal is to identify skeleton-derived factors that accelerate vascular aging through blood circulation. With this work we hope to develop unconventional but promising paths for the treatment of cardiovascular and cerebrovascular diseases.

PI_NAMEs: WAN, MEI  (contact)

PROGRAM_OFFICER_NAME: WANG, FEI

PROJECT_TERMS: Ablation;Acceleration;Acute;Age;age related;aged;Aging;aging mechanism;Angiogenic Factor;animal old age;Aorta;arterial stiffness;Attenuated;Blood;Blood capillaries;Blood Circulation;Blood Vessels;bone;bone age;Bone Density;Bone Marrow;Bone Marrow Transplantation;bone metabolism;Bone Resorption;Brain;calcification;Cardiovascular Diseases;Cardiovascular system;CDKN2A gene;Cell Aging;Cell Lineage;Cell secretion;cell type;Cells;cerebral capillary;cerebrovascular;Cerebrovascular Disorders;cerebrovascular pathology;Cerebrovascular system;Cerebrum;Clinical;Clinical Research;cognitive change;conditional knockout;Data;defined contribution;Dementia;density;Development;disability;Distal;Elderly;Endocrine Glands;Event;experimental study;Exposure to;Genetic;Goals;Health;Homeostasis;Hormonal;human old age (65+);human subject;Image;Impairment;Incidence;Infusion procedures;Knockout Mice;Link;Longitudinal Studies;Macrophage;Macrophage Colony-Stimulating Factor;Mediating;monocyte;Mononuclear;Morbidity - disease rate;mortality;mouse model;Mus;Neurodegenerative Disorders;novel;Nuclear;old mice;Organ;Osteoclasts;Osteoporosis;Parabiosis;Pathologic;Patients;Peripheral;Phenotype;Physiological;Physiology;Plasma;platelet-derived growth factor BB;Population;Positioning Attribute;pro-aging;public health relevance;Reporter;response;Risk Factors;Role;senescence;senescence associated secretory phenotype;senescent cell;Serum;skeletal;Skeleton;Source;Techniques;Testing;Tissues;TNFSF11 gene;Transgenic Mice;Vascular System;White Matter Disease;Work

PROJECT_TITLE: Identifying A Skeleton-Derived Factor for Vascular Aging


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science

ORG_CITY: BOSTON

ORG_DEPT: NEUROSCIENCES

ORG_NAME: TUFTS UNIVERSITY BOSTON

ORG_STATE: MA

PHR: Narrative The Tufts Post Baccalaureate Research Education Program (PREP) prepares recent college graduates who are members of underrepresented groups with the tools to enter into highly ranked biomedical PhD or MD/PhD programs, succeed and go on to join the next generation of scientific leaders. The program connects each trainee with one of our PhD programs and combines hands-on research training with a faculty mentor and a faculty research advisory committee with classes and workshops that help trainees self-identify as a scientist and develop the skills necessary to succeed in a research career.

PI_NAMEs: RIOS, MARIBEL  (contact)

PROJECT_TERMS: Academia;Acute;Address;advanced analytics;Advisory Committees;anti-racism;Awareness;Basic Science;Biomedical Research;biomedical scientist;career;career networking;cohort;Collaborations;college;Communication;Communities;Critical Thinking;cultural competence;Data;design;Development Plans;Doctor of Philosophy;Education;education research;Educational process of instructing;Educational workshop;Effectiveness;efficacy evaluation;Elements;Ensure;Environment;Evaluation;expectation;experience;Faculty;faculty mentor;faculty research;Feedback;Fostering;Foundations;Funding;Goals;graduate school;graduate student;Growth;hands on research;Immersion;implicit bias;improved;Individual;Industry;innovation;Institution;International;Interview;Journals;Leadership;Life;medical schools;meetings;member;Mentors;Methods;Mission;Monitor;multidisciplinary;next generation;Oral;Outcome;Paper;peer coaching;Peer Review;Postbaccalaureate;Postdoctoral Fellow;prevent;Process;Productivity;Professional Competence;programs;Publications;Reproducibility;Research;Research Project Grants;Research Training;resilience;Role;role model;Scholarship;Science;Scientist;skills;social;social capital;Social isolation;social skills;Students;success;support network;symposium;Syndrome;Technology;Time;tool;Training;Training Programs;Underrepresented Populations;Universities;Vocational Guidance;Work;Workplace;Writing

PROJECT_TITLE: Tufts Post-Baccalaureate Research Education Program

STUDY_SECTION_NAME: Training and Workforce Development Study Section - D[TWD-D]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Overall NARRATIVE. Women are at twice the risk of the co-occurrence of depression and autonomic dysregulation, which is associated with a 3-5-fold risk of death from heart disease later in life, often with unrecognized and untreated depression. This SCORE will conduct a set of basic science and clinical studies that are synergistic for understanding the risk for sex differences in depression and associated health outcomes over the lifespan. We will identify pathways that will lead to translation into sex-selective therapeutics and will train the next generation to incorporate knowledge of sex differences into how we think about and treat disorders of the brain and their impact on general medicine.

PI_NAMEs: GOLDSTEIN, JILL M (contact);TOBET, STUART A.

PROGRAM_OFFICER_NAME: EVANS, JOVIER D

PROJECT_TERMS: Adult Children;Amygdaloid structure;Anterior;Anxiety;Area;Attenuated;Autonomic Dysfunction;Autonomic nervous system;Basic Science;biological adaptation to stress;Biological Markers;Brain;brain circuitry;Brain Diseases;Brain imaging;Cardiac;Cardiovascular Diseases;career;Centers of Research Excellence;cingulate cortex;Clinical;clinical effect;Clinical Investigator;Clinical Research;Collaborations;Communities;comorbidity;Corticotropin-Releasing Hormone;Coupled;CRH gene;Cytokine Receptors;Data Analytics;depressive symptoms;Development;Devices;disability;Disease;early detection biomarkers;Early Intervention;effective therapy;Faculty;Fetal Development;Functional disorder;Genes;Glucocorticoid Receptor;Gonadal Steroid Hormones;Health;Heart Diseases;heart function;high risk;Hippocampus;Hormone secretion;Hormones;Hydrocortisone;Hypothalamic structure;hypothalamic-pituitary-adrenal axis;Immune;immune function;Immune response;in utero;Interleukin-6;Knowledge;late life;Leadership;Life;life span;Major Depressive Disorder;Maps;Medical;Medicine;men;Mental Depression;middle age;Mission;Moods;mortality risk;Myocardial Ischemia;Nerve;Neuroanatomy;Neurons;neuroregulation;Neurosciences;neurovascular;next generation;novel therapeutics;Outcome;paraventricular nucleus;Pathway interactions;Peripheral;Physiological;Physiology;Policy Maker;Population;Prefrontal Cortex;prenatal;prenatal stress;Public Health;Receptor Activation;Recurrence;Resources;respiratory;response;Risk;Rodent Model;Scientist;Series;sex;Sex Differences;sexual dimorphism;Sexual Dysfunction;Specialized Center;Steroid Receptors;Stress;stress reactivity;Study models;success;Technical Expertise;Technology;Testing;Therapeutic;therapeutic development;TNF gene;Training;Translating;translational study;Translations;vagus nerve stimulation;Woman;Women's mortality

PROJECT_TITLE: Sex Differences in Major Depression: Impact of Prenatal Stress-Immune and Autonomic Dysregulation


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Depression;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Pediatric;Serious Mental Illness;Women's Health Research

PHR: LAC Narrative The goals of the proposed SCORE are to identify stress-immune pathway abnormalities beginning in fetal development that impact key stress-related neural circuits resulting in shared consequences for sex differences in lifelong depression and autonomic and other physiologic dysregulation. Our SCORE proposes a set of synergistic basic and clinical studies in tandem with cores to share technological expertise and enhance the training of the next generation. The LAC will oversee responsibility for: maintaining connections between sites and studies, setting up meetings and conference calls to review study progress, budget administration, organizing symposia and conferences, publicizing opportunities for trainees, supporting new initiatives, and implementing dissemination of the knowledge gained to the scientific and medical communities, policy makers, and the public.

PI_NAMEs: GOLDSTEIN, JILL M (contact)

PROJECT_TERMS: Animal Model;Animals;Biological Models;brain circuitry;Budgets;Cardiovascular Diseases;career;Centers of Research Excellence;Clinical;Clinical Investigator;Clinical Medicine;Clinical Research;Collaborations;Communities;Consultations;Country;disability;Discipline;Disease;disorder risk;Early Intervention;Educational workshop;Electronic Mail;Endocrinology;Evaluation;Expenditure;Fetal Development;Functional disorder;Funding;Future;Genetic;Goals;Heart Diseases;high risk;Hormones;Human;Immune;Immune response;Immunology;Infrastructure;Institution;Interdisciplinary Study;Knowledge;late life;Leadership;Life;Locales;Major Depressive Disorder;Medical;meetings;Mental Depression;Metabolic Diseases;Methodology;Methods;middle age;Mission;Modeling;Monitor;Moods;mortality risk;neural circuit;Neurology;Neurosciences;neurovascular;next generation;novel;novel strategies;Pathway interactions;Peripheral;Physiological;Policy Maker;Population;prenatal stress;Psychiatry;Public Health;Publications;Radiology Specialty;Recurrence;Reporting;Resources;Risk;Schedule;Scientist;Series;sex;sex as a biological variable;Sex Differences;Site;Specialized Center;specific biomarkers;Stress;symposium;synergism;Technology;Telephone;Therapeutic;Thinking;Time;tool;Training;Translating;Translational Research;translational study;United States National Institutes of Health;web site;Woman;Women's mortality;Work

PROJECT_TITLE: Leadership Administrative Core

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-EMNR-A]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Mental Health;Mental Illness;Neurosciences

ORG_CITY: PROVIDENCE

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: PROJECT NARRATIVE Our findings have the potential to describe the neural computations that form the basis for amotivation, a known transdiagnostic factor across several psychiatric and neurological disorders, including depression and schizophrenia. This research can therefore enable endophenotypic assessment of risk for these disorders and severity of motivational impairments in subclinical populations, providing a potential biomarker to aid in diagnosis and treatment outcome research, and facilitating development of and tests of efficacy for therapies aimed at reducing these impairments. This work carries promising future directions for studying motivational impairments in depression, schizophrenia, Alzheimer’s, and Parkinson’s, and to improve well-being and increase productivity in the general population.

PI_NAMEs: SHENHAV, AMITAI  (contact)

PROGRAM_OFFICER_NAME: ROSSI, ANDREW F

PROJECT_TERMS: Adult;Alzheimer's Disease;Anterior;Attention;Behavior;career;Chronic;cingulate cortex;Cognitive;cognitive control;Computer Models;Cost Analysis;Costs and Benefits;Cues;daily functioning;Decision Making;Development;Diagnosis;Diagnostic;Diagnostic Factor;Disease;disorder risk;Dissociation;Dorsal;efficacy testing;Electroencephalography;endophenotype;Environment;Evaluation;Event-Related Potentials;expectation;experience;Feedback;Functional Magnetic Resonance Imaging;functional magnetic resonance imaging/electroencephalography;Future;General Population;Goals;health goals;Impairment;improved;Incentives;indexing;Individual;Individual Differences;information processing;insight;Investments;Learning;Major Depressive Disorder;Measures;Mental Depression;Mental disorders;Modeling;Motivation;Multivariate Analysis;Nervous System Disorder;neural;neural circuit;novel;Outcomes Research;Output;Parkinson Disease;Participant;Pattern;Personal Satisfaction;Persons;Population;potential biomarker;Productivity;Prognosis;programs;Psyche structure;Research;response;Rewards;Risk Assessment;Schizophrenia;Severities;Signal Transduction;Source;Stimulus;Techniques;Testing;Treatment Efficacy;Treatment outcome;Update;Work

PROJECT_TITLE: Neural and computational mechanisms of motivation and cognitive control

STUDY_SECTION: CP

STUDY_SECTION_NAME: Cognition and Perception Study Section[CP]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Pediatric;Precision Medicine;Prevention;Serious Mental Illness;Social Determinants of Health;Women's Health Research

PHR: The proposed Career Enhancement Core (CEC) will train the next generation of scientists in sex differences research as relevant to major depression. It will provide individually-tailored support to individuals with a range of previous training and experience, through a combination of a structured didactic curriculum, mentored research project, and formal career development training. Under the supervision of an accomplished, multidisciplinary faculty and with access to the latest methods in translational research, our trainees will be well prepared to become leaders in the field of sex difference research.

PI_NAMEs: SMOLLER, JORDAN W (contact)

PROJECT_TERMS: Address;Advocacy;Arizona;attenuation;Award;Behavior;Biology;Biomedical Engineering;biomedical resource;Brain;Brain Diseases;career;career development;Center for Translational Science Activities;Clinical;Clinical Research;Clinical Sciences;Collaborations;Colorado;Development;didactic education;disability;Disease;Early Intervention;Educational Curriculum;Educational Status;empowerment;Environmental Risk Factor;Etiology;experience;Faculty;Family;Family member;fetal programming;Fostering;Funding;Future;Gender;gender disparity;Genes;Genetic;Genomics;Health;health care service utilization;health difference;health disparity;Healthcare;Healthcare Systems;Heart;heart function;Home;Hormones;Hospitals;Human;imaging facilities;Immune;improved;Individual;Infrastructure;insight;Institution;Interdisciplinary Study;interest;knowledge translation;life span;Major Depressive Disorder;Massachusetts;Medical;medical schools;Medicine;Mental disorders;Mentors;Mentorship;Metabolic;metabolomics;Methodology;Methods;Modeling;Moods;Morbidity - disease rate;multidisciplinary;new technology;next generation;novel strategies;offspring;Outcome;Participant;Pathology;Pathway interactions;Pattern;personalized medicine;Persons;Physiology;Play;Policies;Population;pre-clinical research;precision medicine;preclinical study;Pregnancy Complications;prenatal stress;Prevention;programs;Proteomics;Public Health Schools;Recording of previous events;Research;research and development;Research Personnel;Research Project Grants;Resources;Rest;Role;Schools;Science;Scientist;sex;Sex Differences;Site;skills;social;steroid hormone;Strategic Planning;Structure;success;Supervision;System;Therapeutic;Therapeutic Research;Training;Training and Infrastructure;Translating;translational model;Translational Research;Translations;United States National Institutes of Health;Universities;Woman;Women's Health;Work

PROJECT_TITLE: Career Enhancement Core


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: PROJECT NARRATIVE Extreme reactivity to sensory stimuli, or Sensory Over-Responsivity (SOR), is present in 50-70% of children across varied neurodevelopmental disorders, but SOR is not well understood and is rarely treated despite being associated with substantial clinical impairment. This project will integrate behavioral, fMRI, and GABA spectroscopy methods in a combined cross-sectional/longitudinal design to identify individual differences in the development of SOR and sensory regulation in children with autism spectrum disorders (ASD). The study will also take a proof-of-mechanism approach to examine the ability of two emotion regulation strategies to engage neural sensory regulation regions, which, taken together with the longitudinal results, will directly translate to personalized and age-appropriate interventions for SOR in youth with ASD.

PI_NAMEs: GREEN, SHULAMITE ABRA (contact)

PROGRAM_OFFICER_NAME: GILOTTY, LISA

PROJECT_TERMS: Adolescence;adolescent with autism spectrum disorder;Adult;Age;age related decline;Amygdaloid structure;Arousal;Attention;Attenuated;autism spectrum disorder;autistic children;behavior measurement;Behavioral;Biological;Brain;Brain region;Child;Childhood;Clinical;Communities;Coping Skills;Cues;Data;design;Development;Developmental Course;Developmental Delay Disorders;developmental disease;Diagnostic;emotion regulation;Emotional;Emotions;follow-up;Foundations;Functional Magnetic Resonance Imaging;gamma-Aminobutyric Acid;Goals;habituation;imaging study;Impairment;improved;Individual;Individual Differences;individuals with autism spectrum disorder;Intervention;Knowledge;knowledge of results;Life;longitudinal analysis;longitudinal design;Loudness;Methods;neural;neurobiological mechanism;Neurodevelopmental Disorder;neuromechanism;neuroregulation;Noise;personalized intervention;Positioning Attribute;Prefrontal Cortex;psychopharmacologic;Regulation;resilience;response;Sampling;Schools;Sensory;sensory cortex;sensory gating;sensory mechanism;sensory stimulus;Severities;social;Social Interaction;Spectrum Analysis;Stimulus;Testing;Thalamic structure;therapy design;Touch sensation;Translating;Translations;Work;Youth

PROJECT_TITLE: Neural mechanisms of sensory reactivity and regulation in autism across development

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Depression;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Pediatric;Serious Mental Illness

PHR: Project Narrative The Resource Support Core (RSC) Core will provide technical support to synthesize and integrate neuroimaging, neuromodulation and physiological methods and analyses across the SCORE Projects. By providing a common image, physiological and experimental data acquisition and analysis framework, the RSC Core will facilitate the ability to perform intra- and inter-project analyses as well as larger-scale analyses. This will integrate not only the SCORE work, but other related NIH-funded studies at the institutions, allowing us to address on a still broader scale questions about sex difference in the neurobiology of MDD and the discovery work for the implementation of a novel, non-invasive therapeutic intervention. Thus, the RSC will increase the value of such data to the broader community when shared according to our Resource Sharing Plan.

PI_NAMEs: NAPADOW, VITALY  (contact)

PROJECT_TERMS: 3-Dimensional;Address;analytical tool;Anatomy;Animal Experiments;Animal Model;Animals;Area;attenuation;Behavioral;biological adaptation to stress;biomedical imaging;Biometry;Blood Vessels;Brain;Brain region;Clinical;Collection;Communities;computerized data processing;Consultations;Data;data acquisition;Data Analyses;Data Pooling;Data Set;data sharing;data structure;database structure;Databases;design;Development;Distributed Databases;Ensure;Etiology;Evaluation;experimental study;Faculty;Fetal Development;Functional Imaging;Functional Magnetic Resonance Imaging;Funding;Glean;Heart;heart rate variability;Human;human model;Human Resources;Image;Image Analysis;Immune;Individual;Infrastructure;Institution;interest;Intervention;Investigation;Magnetic Resonance Imaging;Major Depressive Disorder;mathematical model;Measurement;Methods;middle age;Mission;Modeling;Moods;Nature;neural;Neuroanatomy;Neurobiology;neuroimaging;neuroinformatics;neuroregulation;Neurosciences;Noise;novel;Outcome;Pathway interactions;Peripheral;Physiologic pulse;Physiological;Physiology;prenatal stress;Rattus;Reproducibility;Research;Research Personnel;Resolution;Resource Sharing;Resources;respiratory;response;Rest;sex;Sex Differences;sharing platform;signal processing;Signal Transduction;Source;Standardization;Stimulus;Stress;synergism;System;Techniques;Testing;Therapeutic Intervention;Time;tool;Transdermal substance administration;Translating;United States National Institutes of Health;vagus nerve stimulation;Vagus nerve structure;web portal;Work

PROJECT_TITLE: Resource Support Core


NIH_SPENDING_CATS: Mental Health;Neurosciences;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: TEMPE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

ORG_STATE: AZ

PHR: Improving Brain Organoid Models by Mediating Metabolic Dysregulation Project Narrative Without accurate models of the human brain, we cannot understand the mechanisms guiding the formation and function of the diversity of human cells and circuits. Brain organoids are a promising model system, but they currently lack appropriate cell type specification and maturation due to high levels of metabolic stress. The proposed studies will use a data-driven approach to target metabolic defects and improve appropriate cell specificity for the more accurate study of human neuroscience.

PI_NAMEs: ANDREWS, MADELINE  (contact)

PROGRAM_OFFICER_NAME: PANCHISION, DAVID M

PROJECT_TERMS: Address;Adopted;Alzheimer's Disease;Animal Model;Benchmarking;Biological Assay;Biological Models;Blood Vessels;Brain;cell cortex;Cell Differentiation process;Cell Line;Cell Transplantation;cell type;Cells;Cellular Stress;Cerebral cortex;Characteristics;Chemicals;cognitive capacity;Complex;Culture Media;Data;Data Set;Defect;Derivation procedure;Development;Disease;endoplasmic reticulum stress;Environment;Excision;Gene Expression;gene network;Genes;genetic signature;gliogenesis;Glucose;Glycolysis;Goals;Growth;Human;human model;Immune;Impairment;improved;In Vitro;in vivo;Knowledge;Laboratories;LIF gene;Link;Mediating;Metabolic;Metabolic stress;Metabolism;Methods;model organism;Modeling;Molecular;Molecular Profiling;Morphology;Mus;Nervous System Disorder;neural;Neurodegenerative Disorders;neurodevelopment;neurogenesis;Neuroglia;Neurons;Neurophysiology - biologic function;Neurosciences;Normal Cell;organoid transplantation;Organoids;Oxygen;Parkinson Disease;Pathway interactions;Phenotype;Physiological;Play;Pluripotent Stem Cells;Population;prevent;Process;programs;Proteins;Protocols documentation;Proxy;Publishing;Regulation;Reporting;response;Role;segregation;self organization;Signal Pathway;Signaling Molecule;single-cell RNA sequencing;small molecule;Specific qualifier value;Specificity;Stem Cell Development;stem cells;Stress;tool;translational study;Transplantation;validation studies;Vulnerable Populations;Work

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cardiovascular;Clinical Research;Depression;Estrogen;Heart Disease;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Pediatric;Prevention;Serious Mental Illness;Women's Health Research

PHR: Project 1 NARRATIVE. Women are at twice the risk of the co-occurrence of MDD and autonomic dysregulation, that is associated with a 3-5-fold risk of death from heart disease, often with unrecognized and untreated MDD. This study will investigate fetal stress-immune antecedents to sex differences in adult MDD, mood circuitry in brain, and associated impact on centrally driven cardiac physiology in early midlife. Identifying early biomarkers for the co-occurrence of MDD, autonomic dysregulation and frank heart disease later in life will provide knowledge to intervene earlier.

PROJECT_TERMS: Adult;Age;Amygdaloid structure;Anterior;Archives;Area;Arousal;Attenuated;Autonomic Dysfunction;Baroreflex;biological adaptation to stress;Biological Markers;Blood Pressure;Brain;brain abnormalities;brain circuitry;Cardiac;Cardiovascular Diseases;cingulate cortex;cohort;Coupled;Cytokine Receptors;Devices;disability;early detection biomarkers;Early identification;Early Intervention;Electrocardiogram;emerging adult;Female;fetal;Fetal Development;follow-up;Follow-Up Studies;Functional disorder;Functional Magnetic Resonance Imaging;Gene Expression;Genes;Genetic;Glucocorticoid Receptor;Gonadal Steroid Hormones;Heart Diseases;heart rate variability;Hippocampus;Homeostasis;Hormones;Human;Hydrocortisone;Hyperactivity;hypercortisolemia;Hypothalamic structure;hypothalamic-pituitary-adrenal axis;Immune;Immune response;immune system function;Immunologic Markers;Immunologic Tests;Impairment;in vivo;Individual;Inflammatory;Innate Immune System;innovation;Interleukin-1 beta;Interleukin-6;Knowledge;Life;life span;Major Depressive Disorder;Measures;Mediating;men;Mental Depression;middle age;Molecular;Moods;mortality risk;Mothers;Myocardial Ischemia;Natural Immunity;neurovascular;neurovascular coupling;novel;novel therapeutics;offspring;Outcome;Pathway interactions;Peripheral;Peripheral Blood Mononuclear Cell;Physiological;Physiology;Prefrontal Cortex;Pregnancy;prenatal;prenatal exposure;prenatal stress;Public Health;recruit;Recurrence;response;Rest;Risk;sex;Sex Differences;sexual dimorphism;steroid hormone;Steroid Receptors;Stress;Testing;Therapeutic;therapeutic development;Time;TNF gene;Transcranial Doppler Ultrasonography;transcriptomics;Variant;Woman;Women's mortality

PROJECT_TITLE: Impact of Sex on Prenatal Stress-Immune Programming of Depression and Autonomic Dysregulation