PHR: Technology Training and Dissemination Core Project Narrative Per the instructions in PAR-20-169, please see Overall Project Narrative.

PI_NAMEs: ROGERS, BUCK E. (contact)

PROJECT_TERMS: Address;Area;Biomedical Research;Clinical;clinical application;Collaborations;Communication;Communities;continuing medical education;COVID-19 pandemic;design;Detection;Development;Disease;Documentation;Education;Educational workshop;Ensure;Event;experience;Fortification;Funding;Funding Mechanisms;Future;Goals;Grant;Health Services Research;Human;Hybrids;imager;imaging facilities;Imaging Techniques;improved;in vivo;innovation;Instruction;interest;International;Investigational New Drug Application;Learning;Link;Marketing;meetings;member;Methodology;Methods;Mission;Modeling;Molecular;National Institute of Biomedical Imaging and Bioengineering;Newsletter;operation;outreach;Positron-Emission Tomography;pre-clinical;preclinical imaging;Process;program dissemination;programs;Publications;quality assurance;Radiochemistry;Radiolabeled;Radiology Specialty;Radiopharmaceuticals;radiotracer;rapid growth;Research;Research Project Grants;Resources;Role;Scientific Advances and Accomplishments;Scientist;Services;Site;social media;success;Techniques;technology research and development;technology training;Testing;Training;Training Programs;Translating;Translational Research;Translations;United States;United States National Institutes of Health;Universities;virtual;web page;web site

PROJECT_TITLE: The PET Radiotracer Translation and Resource Center (PET-RTRC) Training & Dissemination


ADMINISTERING_IC: HL

ARRA_FUNDED: N

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Clinical Research;Clinical Trials and Supportive Activities;Hematology;Infectious Diseases;Lung;Patient Safety;Prevention;Rare Diseases;Sepsis

ORG_CITY: SEATTLE

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: PROJECT NARRATIVE The GRAIL Phase 3 study is a confirmatory randomized placebo-controlled clinical trial to examine whether the use of an antiviral drug called ganciclovir can safely and effectively prevent reactivation of a common virus called cytomegalovirus and improve clinical outcomes in adults with sepsis-associated acute respiratory failure. This U24 application proposes to establish and operate a U24 Data Coordinating Center, to provide statistical and data management support for the proposed GRAIL Phase 3 study.

PI_NAMEs: LEISENRING, WENDY M (contact)

PROGRAM_OFFICER_NAME: ZHOU, GUOFEI

PROJECT_TERMS: Acute respiratory failure;Adult;Animal Model;Anti-viral Agents;Area;Clinical;clinical efficacy;Clinical Trials Data Monitoring Committees;Collaborations;Communication;Companions;Critical Illness;Cytomegalovirus;Data Collection;Data Coordinating Center;data management;Data Set;Electronics;Event;flexibility;Functional disorder;Funding;Ganciclovir;Health Expenditures;improved;improved outcome;Incidence;Leadership;Lung;Manuscripts;Mechanical ventilation;Monitor;Morbidity - disease rate;mortality;National Heart, Lung, and Blood Institute;Observational Study;operation;Outcome;Patients;Pharmacological Treatment;Phase;phase 3 study;phase II trial;phase III trial;prevent;primary outcome;Procedures;Process;Prone Position;Prophylactic treatment;protocol development;Protocols documentation;quality assurance;randomized placebo controlled trial;randomized placebo-controlled clinical trial;Reporting;Resource Sharing;Respiratory Failure;Safety;Sample Size;secondary outcome;Sepsis;seropositive;Services;Site;Statistical Data Interpretation;Supportive care;Survivors;Time;tool;trend;trial design;Ventilator;Virus

PROJECT_TITLE: 2/2 Ganciclovir to Prevent Reactivation of Cytomegalovirus in Patients with Acute Respiratory Failure and Sepsis

STUDY_SECTION: CLTR

STUDY_SECTION_NAME: Clinical Trials Review Study Section[CLTR(JA)]


ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

ORG_CITY: WORCESTER

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

ORG_STATE: MA

PHR: OVERALL - Project Narrative In this project, we will develop new gene therapy drugs to treat genetic emphysema due to alpha-1 antitrypsin deficiency (AATD), a common genetic disease and form of chronic obstructive pulmonary disease (COPD). In the proposal, we will use advanced gene editing tools to create genetically defined animal models of AATD (known as transgenic animals), both in mice and in ferrets, which are a good model to study lung diseases. In the course of the study, we will use the most cutting-edge tools in gene therapy, gene editing, and immune modulation to treat AATD in both animal models, and determine the best ways to measure the success of gene therapy over time.

PI_NAMEs: FLOTTE, TERENCE R. (contact)

PROGRAM_OFFICER_NAME: LACHOWICZ-SCROGGINS, MARRAH ELIZABETH

PROJECT_TERMS: Address;Adenine;adeno-associated viral vector;Affinity;airway obstruction;Alleles;alpha 1-Antitrypsin;alpha 1-Antitrypsin Deficiency;Amaze;Animal Model;Antibody Response;Antigen Receptors;base editing;base editor;Biodiversity;Biological Assay;Biological Markers;Capsid;cell mediated immune response;chimeric antigen receptor T cells;China;Chronic Obstructive Pulmonary Disease;Clinical;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;collaborative environment;comparative efficacy;Complex;CRISPR/Cas technology;Cryoelectron Microscopy;Deaminase;delivery vehicle;Densitometry;design;Disease;disease model;Doctor of Philosophy;Elastin;Environment;enzyme activity;enzyme linked immunospot assay;Enzymes;European ancestry;Exhibits;Faculty;Ferrets;Future;gene delivery system;gene editing technology;gene product;gene replacement;Gene Silencing;gene therapy;Gene Transduction Agent;Genes;Genetic;Genetic Diseases;Homozygote;Human;Human Genetics;Hybrids;Immune Evasion;Immune response;immunogenic;Immunology;immunoregulation;Impairment;improved;innovation;Interferon Type II;Laboratories;Lead;Libraries;Life;Liver;Lung;Lung CAT Scan;Lung Diseases;Measurement;Measures;Mechanics;Mediating;meter;Modeling;Molecular;mouse model;Mus;Muscle;mutant;Mutation;neutralizing antibody;neutralizing monoclonal antibodies;new technology;next generation;nonhuman primate;novel;Other Genetics;Outcome;Pharmaceutical Preparations;Phenotype;Physiological;Physiology;Population;prime editing;prime editor;programs;Property;Proteins;Pulmonary Emphysema;Pulmonary Inflammation;Recombinant adeno-associated virus (rAAV);reconstitution;Regulatory T-Lymphocyte;Research Personnel;response;RNA-Directed DNA Polymerase;Role;Safety;screening;Serotyping;Serum;Site;Structure-Activity Relationship;success;System;Technology;technology platform;Testing;Time;tool;Transducers;Transgenes;Transgenic Animals;Transgenic Organisms;treatment response;Variant;vector;Veterinary Medicine;Veterinary Schools;Wild Type Mouse

PROJECT_TITLE: Models and Gene Therapies for AAT Deficiency

STUDY_SECTION: HLBP

STUDY_SECTION_NAME: Heart, Lung, and Blood Program Project Study Section[HLBP(MA)]


PHR: Project Narrative Not Applicable.

PROJECT_TERMS: Accounting;Administrative Efficiency;alpha 1-Antitrypsin Deficiency;Budgets;Communication;Complex;Consultations;data exchange;Ensure;Faculty;Feedback;gene therapy;Goals;Grant;Human Resources;Iowa;Massachusetts;medical schools;meetings;member;Modeling;Occupational activity of managing finances;Persons;programs;Progress Reports;Research;Research Personnel;Schedule;Scientist;Structure;therapeutic RNA;Time;Universities;virtual;Work

STUDY_SECTION_NAME: Heart, Lung, and Blood Program Project Study Section[HLBP]


NIH_SPENDING_CATS: Biotechnology;Gene Therapy;Genetics;Orphan Drug;Rare Diseases

PI_NAMEs: GAO, GUANGPING  (contact)

PROJECT_TERMS: adeno-associated viral vector;adenovirus mediated delivery;alpha 1-Antitrypsin Deficiency;Antibodies;Antigens;B-Lymphocytes;Binding;Biological Assay;Capsid;cell mediated immune response;Cell Therapy;Clinic;Clinical Trials;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;Cystic Fibrosis;cytokine;cytotoxic;Data;Disease;disease model;disease phenotype;Dose;Engineering;enzyme linked immunospot assay;Enzyme-Linked Immunosorbent Assay;Evaluation;Ferrets;Flow Cytometry;Gene Delivery;gene product;gene therapy;Gene Transduction Agent;Goals;Grant;Human;Humoral Immunities;Immune;Immune response;Immune system;Immunity;immunogenic;Immunological Models;Immunology;Immunology procedure;Inflammatory;Measures;Mediating;Modeling;Monkeys;mouse model;Mus;Neutralizing antibody assay;novel;Outcome;Patients;Program Research Project Grants;Proteins;Protocols documentation;Reagent;Regulatory T-Lymphocyte;Resources;Respiratory Tract Infections;response;Role;Serious Adverse Event;Serology;Stains;Standardization;Steroids;T cell response;T-Lymphocyte;Testing;Therapeutic;therapeutic genome editing;transgene expression;Transgenes;vector;Virus

PROJECT_TITLE: Vector Immunology Core


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: HOUSTON

ORG_NAME: METHODIST HOSPITAL RESEARCH INSTITUTE

ORG_STATE: TX

PHR: Quantitively decoding how cell fate changes can provide novel mechanistic insight into organogenesis and tissue regeneration, and help identify new strategies for the treatment of human diseases. This project aims to develop the first computational methods and toolkits for generating cell dynamics atlases and analyzing cell state transition and its regulation based on the appropriate reference atlases. The ability to build cell dynamics reference landscapes will open a new horizon to understand the diversity of cell fate through comparative analyses across tissues and diseases and enhance regenerative medicine.

PI_NAMEs: WANG, GUANGYU  (contact)

PROGRAM_OFFICER_NAME: WANG, PEGGY

PROJECT_TERMS: Address;Alzheimer's Disease;Atlases;Biological;cardiogenesis;Cell Differentiation process;Cell Fate Control;Cells;comparative;computerized tools;Computing Methodologies;Data Set;Development;Disease;epigenetic regulation;Foundations;Goals;Health;Heart failure;Hematopoiesis;Human;human disease;insight;Knowledge;Learning;mathematical methods;Multiomic Data;multiple omics;neurogenesis;Non-Insulin-Dependent Diabetes Mellitus;novel;novel strategies;novel therapeutic intervention;Obesity;Organ;organ growth;Organogenesis;Pathogenesis;Population;Regenerative Medicine;Regulation;Research;Role;Statistical Models;Study models;tissue regeneration;Tissues;transcriptome;transdifferentiation

PROJECT_TITLE: Landscapes for Cell State Transition Leveraging by Single-Cell Multi-Omics

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Mental Health;Mental Illness;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: ATLANTA

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE We seek to extend follow-up of our Atlanta ECHO Cohort participants under the ECHO Protocol and participate in solution-oriented ECHO team science. The unique contributions of our Cohort Study site include our demonstrated capacity to follow hard-to-reach racial and ethnic minority families (as our cohort is wholly composed of Black American families, 75% of whom are of lower socioeconomic status); our geographic location in a major metropolitan area in the US Southeast that experiences unique regional and area-level stressors (e.g., racialized segregation, structural racism); and our multi-disciplinary team of psychosocial, clinical, and omic investigators with expertise in (personalized) exposure assessment, maternal stress, perinatal and birth outcomes, and child neurodevelopment.

PI_NAMEs: BRENNAN, PATRICIA A;DUNLOP, ANNE LANG (contact)

PROGRAM_OFFICER_NAME: ZANETTI, KRISTA A

PROJECT_TERMS: 7 year old;accelerated epigenetic aging;Adherence;African American;Age Months;Allergic;Anxiety;Area;Asthma;Attention deficit hyperactivity disorder;autism spectrum disorder;Behavior;Bifidobacterium;Biological;Birth;Black American;Child;Child Health;Clinical;cognitive function;cohort;Cohort Studies;community intervention;Data;design;Diet;Discrimination;Disease;disorder risk;DNA Repair;early childhood;Enrollment;Epigenetic age;Epigenetic Process;epigenome;ethnic minority;Executive Dysfunction;experience;Exposure to;Family;follow-up;Future;Genetic Transcription;Geographic Locations;Gestational Age;Health behavior;health disparity;improved;Individual;Intervention;Investigation;Lead;Low Birth Weight Infant;low socioeconomic status;Maternal and Child Health;maternal stress;Measures;Mediating;Mediator;Mental Depression;Mental disorders;Metabolic Pathway;metabolome;metropolitan;microbiome;Mothers;multidisciplinary;National Institute on Minority Health and Health Disparities;Nerve Degeneration;neurodevelopment;Neurodevelopmental Disorder;novel;Obesity;Outcome;Participant;participant retention;Pathway interactions;Pediatric cohort;pediatric health outcomes;perceived discrimination;Perinatal;perinatal health;perinatal outcomes;Phenotype;Physical activity;Post-Traumatic Stress Disorders;Postpartum Depression;Postpartum Period;Pregnancy;Pregnancy Complications;pregnancy health;Premature Birth;prenatal;prenatal experience;prenatal exposure;prenatal health;prenatal stress;Process;prospective;protective factors;protective pathway;Protocols documentation;psychological distress;Psychopathology;psychosocial;Psychosocial Stress;racial discrimination;racial disparity;racial minority;Racial Segregation;racism;Reporting;Research;Research Personnel;Risk;Role;Sampling;Science;Site;Sleep;Sleep disturbances;sleep quality;social;social cohesion;Social Functioning;Social support;sociodemographics;Southeastern United States;Stress;stressor;Structural Racism;substance use;systematic review;Testing;Variant;Visit

PROJECT_TITLE: Atlanta ECHO Pediatric Cohort:  Examining -omics pathways from prenatal exposures to child neurodevelopment

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-EPH-S(50)R]


NIH_SPENDING_CATS: Biotechnology;Chronic Obstructive Pulmonary Disease;Gene Therapy;Genetics;Lung;Orphan Drug;Rare Diseases

PI_NAMEs: GRUNTMAN, ALISHA MARIE (contact)

PROJECT_TERMS: Albumins;Alleles;alpha 1-Antitrypsin Deficiency;Animal Model;Benchmarking;Biological Assay;Blood;Breeding;Bronchoalveolar Lavage;Capsid;Clinical;clinically relevant;Collaborations;Disadvantaged;disease model;Disease Progression;Dose;Elastases;Engraftment;Enterobacteria phage P1 Cre recombinase;Ferrets;gene therapy;gene-editing approach;Genes;genome editing;Growth;Hepatocyte;Human;Human Genetics;humanized mouse;immunodeficiency;Iowa;Knock-in Mouse;Knockout Mice;Laboratories;Libraries;Liver;LoxP-flanked allele;Lung;Lung Diseases;Modeling;mouse genetics;mouse model;Mus;Mutation;novel;Patients;Phenotype;Physiological;Physiology;Play;Production;promoter;pulmonary function;Pulmonary function tests;Residual state;response;Rodent;Role;screening;Serotyping;success;Testing;Therapeutic;therapeutic evaluation;Therapeutic Intervention;Time;Transgenes;Treatment Efficacy;Universities;Veterinary Medicine;Veterinary Schools;Work;X-Ray Computed Tomography

PROJECT_TITLE: Human Genetic Disease Modeling and Physiology Core


NIH_SPENDING_CATS: Biotechnology;Chronic Obstructive Pulmonary Disease;Emphysema;Gene Therapy;Genetics;Lung;Orphan Drug;Rare Diseases

PROJECT_TERMS: Age;airway obstruction;Albumins;Alleles;alpha 1-Antitrypsin Deficiency;Animal Model;Animals;Biological Markers;Capsid;China;Chronic Obstructive Pulmonary Disease;Clinical;clinical efficacy;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;comparative efficacy;Consumption;CRISPR/Cas technology;Densitometry;density;design;Development;disease model;Dose;effectiveness evaluation;Elasticity;Elastin;Enterobacteria phage P1 Cre recombinase;Environment;Estrogen Receptors;European ancestry;Exposure to;Ferrets;Future;gene editing technology;gene replacement;gene therapy;Gene Transduction Agent;Genes;Genetic;Genetic Diseases;Genetic study;Glycoproteins;Histology;Homozygote;Human;Human Genetics;Impairment;improved;Inflammatory;Infusion procedures;innovation;interstitial;Intravenous infusion procedures;Iowa;Knock-in;Knock-out;Knockout Mice;Laboratories;Leukocyte Elastase;Life;Liver;LoxP-flanked allele;Lung;Lung CAT Scan;Lung Diseases;lung histology;lung preservation;Mediating;Mendelian disorder;meter;Modeling;Modification;Mus;mutant;Mutation;neutrophil;nonhuman primate;novel;novel strategies;novel therapeutics;Outcome;Outcome Measure;Patients;Phenotype;Physiology;Plasma;Population;Process;product development;promoter;prospective;Prospective Studies;Protease Inhibitor;Proteins;Pulmonary Emphysema;pulmonary function;Pulmonary Inflammation;Radiology Specialty;randomized, clinical trials;Recombinant adeno-associated virus (rAAV);recombinant virus;reconstitution;response;Serum;Signal Transduction;Stimulus;Structure of parenchyma of lung;Tamoxifen;targeted treatment;Testing;Time;Tissue Preservation;tool;Transgenes;Transgenic Animals;Transgenic Organisms;Universities;vector

PROJECT_TITLE: Optimized Gene Replacement for AAT deficiency and Modeling of Clinical Outcomes in small and large animal models


NIH_SPENDING_CATS: Biotechnology;Chronic Obstructive Pulmonary Disease;Digestive Diseases;Emphysema;Gene Therapy;Genetics;Liver Disease;Lung;Rare Diseases

PI_NAMEs: XUE, WEN  (contact)

PROJECT_TERMS: Address;Adenine;adenosine deaminase;adenovirus mediated delivery;Adult;Affect;Airway Disease;Alleles;alpha 1-Antitrypsin Deficiency;Animal Model;Antibodies;Antigens;base editing;base editor;Candidate Disease Gene;Capsid;cell type;Cells;Circulation;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Deaminase;Deamination;Dependovirus;Disease;disease model;DNA Repair;Endonuclease I;Engineering;gene correction;gene therapy;Generations;Genes;Genomics;genotoxicity;Goals;Guanosine;Guide RNA;Hepatocyte;Human Genetics;Immune;Immune response;Immunology;improved;in vivo;Individual;Inosine;Leukocyte Elastase;Liver;Liver diseases;Lung;Measures;Mediating;Mendelian disorder;Modeling;mouse model;Mus;mutant;Mutation;mutation correction;novel;Organ;Patients;Phenotype;Physiology;Point Mutation;Polymers;pre-clinical;prime editing;prime editor;protein aggregation;Proteins;Pulmonary Emphysema;Regulatory T-Lymphocyte;repaired;response;RNA Editing;RNA-Directed DNA Polymerase;Safety;Serine Proteinase Inhibitors;Serum;Specificity;synergism;T cell response;Technology;Therapeutic;tool;Transgenic Mice;Variant;vector;Viral;Work

PROJECT_TITLE: Editing of the AAT locus using novel base editing and prime editing technologies


NIH_SPENDING_CATS: Biotechnology;Digestive Diseases;Gene Therapy;Genetics;Liver Disease;Rare Diseases

PI_NAMEs: WANG, DAN  (contact)

PROJECT_TERMS: Address;adeno-associated viral vector;alpha 1-Antitrypsin;alpha 1-Antitrypsin Deficiency;Amaze;Amino Acids;Bar Codes;base editing;Biodiversity;Capsid;case-based;chimeric antigen receptor;clinical translation;Clinical Trials;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;Collection;Complex;Cryoelectron Microscopy;design;Dose;Ferrets;Gene Delivery;Gene Expression;gene replacement;gene therapy;gene therapy clinical study;Gene Transfer;gene-editing approach;Genes;Hepatocyte;Human;human tissue;humanized mouse;Hybrids;Immune;Immune response;Immunity;Immunologics;in vivo;Length;Libraries;Liver;Mediating;meter;Modeling;mouse model;Mus;neutralizing antibody;nonhuman primate;novel;Outcome;permissiveness;Plasma;Population;pre-clinical;Primates;prime editing;promoter;Property;Recombinant adeno-associated virus (rAAV);reconstitution;Regulatory T-Lymphocyte;Serotyping;single molecule real time sequencing;structural biology;structural determinants;tissue tropism;Tissues;Transducers;transgene expression;Tropism;Variant;vector;vector induced;Wild Type Mouse

PROJECT_TITLE: Exploitation of the natural biodiversity of AAV to identify “super transducers"


NIH_SPENDING_CATS: Asthma;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: NARRATIVE The term asthma is an umbrella diagnosis for several disease states with distinct variable clinical presentations (phenotypes) and mechanistic pathways (endotypes). In clinical care for childhood asthma, treatments are largely applied universally to all children with asthma, even though it has been shown that some treatments we use may not benefit certain asthma sub-types. The focus of this proposal is to define clinical asthma sub-types so that they may be easily identified in clinical practice, understand their distinct disease biology, and determine what risk factors promote asthma sub-type development with the goal to have targeted treatment and prevention strategies.

PI_NAMEs: BACHARIER, LEONARD B;HARTERT, TINA V (contact)

PROGRAM_OFFICER_NAME: ARTEAGA, SONIA S

PROJECT_TERMS: Address;Adolescence;Age;airway epithelium;Allergens;Allergic;Asthma;asthma prevention;Biological;Biological Markers;Biological Response Modifier Therapy;Biological Response Modifiers;Biological Specimen Banks;Biology;Birth;Blood specimen;Child;Child Health;Childhood Asthma;Clinical;clinical care;clinical practice;clinically relevant;cohort;Cohort Studies;Collection;comparative;comparison group;Data;Data Collection;Data Element;Development;Diagnosis;diagnostic criteria;diagnostic development;differential expression;Disease;Disease Management;disorder prevention;DNA;early life exposure;Enrollment;Ensure;Environmental Exposure;Environmental Risk Factor;eosinophil;ethnic diversity;Ethnic Origin;Exhalation;fecal microbiome;follow-up;Funding;Genes;Genetic Transcription;Genotype;Geographic Locations;Geography;Goals;Hypersensitivity skin testing;IgE;Incidence;Individual;Infant;innovation;Laboratories;Measures;Mentors;Methodology;middle childhood;Morbidity - disease rate;multidimensional data;Nitric Oxide;Nose;novel;Outcome;Participant;Pathway interactions;Phenotype;policy implication;Population;population based;Population Heterogeneity;Poverty;Prevalence;Prevention strategy;protective factors;Protocols documentation;Publications;Pulmonary function tests;Race;racial diversity;Research;respiratory;respiratory microbiome;Respiratory syncytial virus;Risk Factors;Role;Rural Community;Sample Size;Sampling;Science;Serology;sex;Southeastern United States;targeted treatment;Technology;Testing;Time;transcriptomics;treatment strategy;Urban Community;viral detection;Viral Respiratory Tract Infection;Visit

PROJECT_TITLE: ECHO Renewal for the INSPIRE Study Cohort


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Clinical Research;Digestive Diseases;Pancreatic Cancer;Rare Diseases

ORG_CITY: NEW YORK

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: Project Narrative  We will investigate the network of paracrine signals communicating between cell types in pancreatic cancer by applying a powerful set of computational algorithms to a new and unique set of human patient samples. We will use a new model system culturing intact human pancreatic tumors in order to test the hypothesis that targeting key paracrine nodes that regulate multiple cell types simultaneously is more effective at counteracting the effects of the tumor microenvironment.

PI_NAMEs: MANJI, GULAM ABBAS;OLIVE, KENNETH P. (contact)

PROGRAM_OFFICER_NAME: UJHAZY, PETER

PROJECT_TERMS: Algorithms;Allografting;analytical tool;angiogenesis;Behavior;Biological Models;Blocking Antibodies;Blood;Blood specimen;cancer cell;candidate selection;CCR1 gene;CD8-Positive T-Lymphocytes;cell type;Cells;chemokine;Clinical;Clinical Services;clinical translation;Clinical Trials;Coculture Techniques;Communication;Complex;Computational algorithm;computational suite;computerized tools;conditioning;cytotoxic;Cytotoxic Chemotherapy;Data;Data Set;Desmoplastic;Diffusion;Dissection;Drug Combinations;Drug Delivery Systems;drug efficacy;Effector Cell;Electronic Medical Records and Genomics Network;Elements;Endothelium;Erinaceidae;Fibroblasts;functional outcomes;Genetic Transcription;Genetically Engineered Mouse;Growth;Heterogeneity;Hospitals;Human;immunosuppressed;Immunosuppression;Immunotherapy;improved;in vivo;Individual;inhibitor;innovation;Intercellular Fluid;Intercept;Investigation;KPC model;Ligands;Link;Logic;Lymphocyte;Lymphoid;Malignant Epithelial Cell;Malignant neoplasm of pancreas;Malignant Neoplasms;Maps;Mediating;member;Metabolic;Methods;Modeling;mouse model;multidisciplinary;mutant;Myelogenous;Myeloid Cells;Myeloid-derived suppressor cells;Myofibroblast;New York;novel;Olives - dietary;Outcome Study;overexpression;Paint;Pancreas;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;pancreatic ductal adenocarcinoma model;pancreatic neoplasm;paracrine;Paracrine Communication;Pathway Analysis;Pathway interactions;Patients;Perfusion;Phenotype;Population;pre-clinical assessment;Presbyterian Church;Primary Cell Cultures;receptor;Recombinant Proteins;Regimen;Regulation;Reporting;Resources;response;restraint;Role;Sampling;Series;SHH gene;Signal Transduction;single cell technology;single-cell RNA sequencing;Slice;Spleen;Stromal Cells;Stromal Neoplasm;System;Systems Biology;targeted agent;targeted treatment;Techniques;Testing;Therapeutic;Therapeutic Agents;Therapeutic Intervention;Tissue Sample;Tissues;tool;Toxic effect;treatment response;tumor;tumor microenvironment;Tumor Tissue;Validation;Work

PROJECT_TITLE: Elucidation and targeting of paracrine cascades in PDAC


NIH_SPENDING_CATS: Biotechnology;Gene Therapy;Genetics;Immunotherapy;Orphan Drug;Rare Diseases

PI_NAMEs: KEELER-KLUNK, ALLISON MAY (contact)

PROJECT_TERMS: Address;adeno-associated viral vector;adenovirus mediated delivery;alpha 1-Antitrypsin;alpha 1-Antitrypsin Deficiency;Animal Model;Animals;Antigens;B-Lymphocytes;base editor;Bystander Effect;Capsid;CD8B1 gene;Cells;Cellular Infiltration;cellular transduction;chimeric antigen receptor;chimeric antigen receptor T cells;Clinic;Clinical;Clinical Trials;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;cytotoxic;Cytotoxic T-Lymphocytes;Data;Dependovirus;Detection;Disease;dosage;Dose;Environment;Ferrets;Gene Expression;gene therapy;gene therapy clinical trial;Gene therapy trial;genome editing;Hemophilia A;Human;Immune;immune cell infiltrate;Immune response;Immune Response Genes;Immune system;Immunity;immunogenic;Immunology;immunoregulation;Immunosuppression;In Vitro;in vivo;Infiltration;Intramuscular Injections;Learning;Mediating;Modeling;mouse model;Muscle;neutralizing antibody;novel;Patients;prime editor;Proteins;Protocols documentation;Regulatory T-Lymphocyte;Reporter Genes;response;T cell response;Technology;Testing;Therapeutic;therapy development;tool;transgene expression;Transgenes;vector;Virus

PROJECT_TITLE: Modulation of Immune responses to gene therapy by Creation of AAV-specific Chimeric antigen receptor regulatory T cells (CAR-Tregs)


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Kidney Disease;Organ Transplantation;Racial and Ethnic Minority Health Research;Social Determinants of Health;Transplantation

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Narrative Kidney transplantation is the preferred kidney replacement therapy in patients with end-stage kidney disease but structural racism impacts access to kidney transplant referrals, evaluations, and waitlistings in Black and Hispanic patients. We propose to address these disparities using a multilevel approach by 1) Use a community health worker (CHW) to identify and manage SDOH-related and symptoms as barriers to kidney transplantation; 2) Have a CHW universally refer eligible patients for kidney transplantation and facilitate clearance appointments; and 3) Identify and educate transplant providers regarding stigmatizing language in transplant evaluation notes. Our project will be co-lead by a Community Stakeholder Board consisting of patients, caregivers, providers, advocates, and dialysis system leaders who will drive development, recruitment and retention, and dissemination of this project.

PI_NAMEs: CHAN, LILI  (contact);HOROWITZ, CAROL R;MELAMED, MICHAL L;NADKARNI, GIRISH NITIN

PROGRAM_OFFICER_NAME: NORTON, JENNIFER MICHELLE

PROJECT_TERMS: Address;Adoption;Adult;Advocate;Appointment;Assessment tool;Black Populations;Black race;Caregivers;Chronic Kidney Failure;Clinical;Clinical Trials;Cluster randomized trial;Collaborations;Communities;community engaged research;Community Health Aides;compare effectiveness;Country;Data;design;Development;Dialysis patients;Dialysis procedure;Disparity;Education;Eligibility Determination;End stage renal failure;Enrollment;Ensure;Equity;ethnic disparity;Evaluation;experience;Face;food insecurity;Fostering;Future;Health;Health system;Healthcare Systems;Hemodialysis;Hispanic;Hispanic Populations;impression;improved;Individual;Inequity;innovation;interest;Intervention;Interview;Kidney;Kidney Failure;Kidney Transplantation;Label;Language;Lead;Link;Low income;Mediating;Medical;Medicine;Mental Depression;Mental Health;Operative Surgical Procedures;optimal treatments;Pain;Patient Care;patient navigator;Patient-Focused Outcomes;Patients;Persons;Policies;Population Heterogeneity;primary outcome;Process;program dissemination;programs;Provider;psychosocial;Race;racial discrimination;racial disparity;Racial Equity;racism;recruit;Renal Replacement Therapy;Research;Research Personnel;Resort;Resources;social;social determinants;social health determinants;Social support;Standardization;Stigmatization;Structural Racism;Structure;success;Symptom Burden;Symptoms;System;Testing;tool;Training;transplant centers;Transplant Recipients;Transplantation;Transportation;treatment as usual;Waiting Lists;Work

PROJECT_TITLE: Renal transplant Equity through Partnership And Structural Transformation (REPAST)


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Genetic Testing;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Patient Safety;Prevention;Social Determinants of Health

PHR: Public Health Statement The IMPACT Study's overarching goals are to improve guideline-adherent cancer risk management among those with P/LP variants or VUS results in inherited cancer genes and increase family communication of genetic test results. Results from this study will help identify and refine interventions to deliver care to patients with P/LP variants and VUS results in inherited cancer genes and their at-risk family members.

PI_NAMEs: CRAGUN, DEBORAH LE;PAL, TUYA  (contact)

PROGRAM_OFFICER_NAME: FILIPSKI, KELLY

PROJECT_TERMS: adaptive intervention;Address;Age;Awareness;Behavior;Behavioral;Black Populations;cancer genetics;cancer predisposition;cancer prevention;cancer risk;cancer therapy;Caring;Characteristics;clinical care;Communication;contextual factors;Control Groups;cost;Data;design;Development;disease-causing mutation;Early Diagnosis;Effectiveness;effectiveness evaluation;effectiveness testing;effectiveness/implementation hybrid;Ethnic Origin;evidence base;Family;Family Cancer History;Family member;feasibility testing;Focus Groups;follow-up;Genes;Genetic Risk;genetic testing;Genomics;Geography;Goals;group intervention;Guidelines;health literacy;Hereditary Disease;Hereditary Malignant Neoplasm;Hereditary Neoplastic Syndromes;high risk;High-Risk Cancer;implementation intervention;implementation outcomes;implementation process;implementation research;improved;improved outcome;Individual;information gathering;Inherited;innovation;Intervention;intervention refinement;Interview;low health literacy;Maintenance;Malignant Neoplasms;Measures;Medical Records;Methods;Modeling;Motivation;Oncogenes;Online Systems;Operative Surgical Procedures;Outcome;overtreatment;Participant;Pathogenicity;Patient-Focused Outcomes;Patients;personalized medicine;pilot test;Policies;Population;Population Heterogeneity;prevent;Prevention;primary outcome;Public Health;Race;Randomized;Randomized, Controlled Trials;recruit;Reporting;Resources;Risk;Risk Management;risk perception;rural dwellers;Sampling;scale up;screening;socioeconomics;Surveys;Syndrome;Technology;Test Result;Testing;Time;tool;Underserved Population;uptake;Variant;variant of unknown significance;web-based intervention

PROJECT_TITLE: IMProving Care After Inherited Cancer Testing (IMPACT) Study


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Bioengineering

ORG_CITY: San Francisco

ORG_NAME: REVEL PHARMACEUTICALS INC.

ORG_STATE: CA

PHR: PROJECT NARRATIVE Advanced glycation end products (AGEs) play an important role in diverse age-related diseases, however no methods exist for rapid, quantitative measurement of AGEs. Revel Pharmaceuticals is developing a rapid, one-pot, inexpensive enzymatic test to measure important AGEs in aging and diabetes.

PI_NAMEs: CRAVENS, AARON  (contact)

PROGRAM_OFFICER_NAME: ASLAN, KADIR

PROJECT_TERMS: Address;adduct;Adsorption;Advanced Glycosylation End Products;age related;age-related disease;Aging;Amino Acids;animal tissue;Antibodies;Antibody Specificity;Antigen Presentation;Antigens;Binding;Binding Proteins;Biological Assay;Biological Markers;Blood;Blood Glucose;Blood Vessels;Body Fluids;Cell model;Cells;Characteristics;Clinical;clinical application;Clinical Medicine;Complications of Diabetes Mellitus;Coupled;Data;Democracy;Detection;detection assay;Development;Diabetes Mellitus;Diagnosis;Diagnostic;Digestion;Disease;Engineering;Enzyme-Linked Immunosorbent Assay;Enzymes;Epitopes;Excision;FDA approved;Food;genetic selection;Glucose;glycation;Glycosylated hemoglobin A;Goals;Human;human tissue;Hydrogen Peroxide;improved;in vitro Assay;innovation;Isotopes;Kinetics;liquid chromatography mass spectrometry;Literature;Lysine;Measurement;Measures;Medicine;Metabolic Diseases;Methodology;Methods;Modeling;Modification;Monitor;Non-Insulin-Dependent Diabetes Mellitus;Oxidases;oxidative damage;Oxidative Stress;Pathologic;Pathway interactions;Patients;Peptide Hydrolases;Performance;Pharmacologic Substance;Phase;Physiological;Play;Proteins;prototype;Pyruvaldehyde;Pyruvate;Reaction;Reagent;repaired;Research;Research Personnel;Risk;Risk Assessment;Role;Sampling;Serum;skin biopsy;Small Business Innovation Research Grant;Sorting;Specificity;stem;sugar;Techniques;Testing;Tissue Sample;Tissues;tool;Uncertainty;Variant

PROJECT_TITLE: An enzyme-based assay for the detection of carboxyethyl lysine-protein adducts

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-J (10)]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Cystic Fibrosis;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza;Rare Diseases

ORG_CITY: CHAMPAIGN

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

ORG_STATE: IL

PHR: Project Narrative The airways of patients with cystic fibrosis and other chronic lung diseases, as well as ventilator-associated pneumonia, are persistently colonized by respiratory bacterial pathogens, many of which are highly recalcitrant to antibiotics. Repeated episodes of microbial infections exaggerate proinflammatory response and cause excessive mucus that clog the airways, leading to reduced gas exchanges, detrimental physiological changes, reduced lung function and increased morbidity and mortality. Examination of the role volatile organic compounds produced by these pathogens that may directly contribute to excessive airway mucus production and deciphering the underlying molecular mechanisms, as proposed in this application, will help to improve the prognosis of patients with these chronic lung diseases.

PI_NAMEs: LAU, GEE W (contact)

PROGRAM_OFFICER_NAME: UPADHYAY, MEENU MISHRA

PROJECT_TERMS: Acute;Acute Disease;Air;Airway Disease;airway epithelium;airway surface liquid;Anabolism;Antibiotics;Aryl Hydrocarbon Receptor;Bacterial Infections;Bacterial Pneumonia;Biological;Blocking Antibodies;bronchial epithelium;Bronchiectasis;Cell Differentiation process;Cell Proliferation;Cells;Chloride Channels;Chronic;Chronic Disease;Chronic lung disease;Chronic Obstructive Pulmonary Disease;Clinical Pathology;combat;CRISPR/Cas technology;Cystic Fibrosis;cystic fibrosis airway;cystic fibrosis mouse;cystic fibrosis patients;Cystic Fibrosis sputum;Cystic Fibrosis Transmembrane Conductance Regulator;Data;Deterioration;diagnostic biomarker;Disease;disease diagnosis;Epidermal Growth Factor Receptor;Epithelial Cells;Escalator;ESKAPE pathogens;Exposure to;Failure;Fluorescence Microscopy;Gases;Genetic Transcription;Goals;Goblet Cells;Homeostasis;Human;Hydrogen Cyanide;Hypoxia;Immune;Immune response;improved;Individual;Infection;Inflammatory Response;Knock-out;Link;Liposomes;Liquid substance;Lung;Lung Diseases;Lung infections;Lymphoid Cell;Macrophage;MAPK3 gene;Mediating;Metaplasia;microbial;microbial colonization;Molecular;Morbidity - disease rate;mortality;MUC5AC gene;MUC5B gene;Mucins;Mucous body substance;mucus clearance;mucus hypersecretion;Mus;mutant;neutrophil;novel strategies;novel therapeutic intervention;Osmosis;overexpression;pathogen;Pathogen detection;Pathogenesis;pathogenic bacteria;Pathogenicity;Pathologic;Pathway interactions;patient prognosis;Patients;Persons;Physiological;Population;potential biomarker;prevent;Primary Ciliary Dyskinesias;Process;Production;Proto-Oncogene Proteins c-akt;Pseudomonas aeruginosa;Pseudomonas aeruginosa infection;Pulmonary Cystic Fibrosis;pulmonary function;Regulatory Pathway;respiratory colonization;Role;secondary metabolite;Signal Pathway;T-Lymphocyte;Testing;Thiocyanates;ventilator-associated pneumonia;volatile organic compound;Western Blotting

PROJECT_TITLE: Mechanistic triggers of excessive mucus during lung infections by bacterial volatile organic compounds


ADMINISTERING_IC: LM

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Biotechnology;Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

ORG_CITY: CLEVELAND

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative To initiate collaborative genome-wide association studies (GWAS) on large genomic datasets, all researchers typically need to go through a long institutional review board (IRB) process to exchange raw datasets that include personal genomes of individuals. This complicates the predictability and timeliness of such studies, because researchers cannot identify valuable collaborators with high confidence without going through the entire IRB process at each institution. The goal of this research is to develop privacy-preserving algorithms within a sandbox environment, which (1) help researchers identify and eliminate low-quality, biased, or statistically dependent records from their federated datasets; (2) generate an accurate preview of researchers’ collaborative GWAS results to provide evidence for benefit versus risk tradeoff in IRB approval; (3) identify what part of the datasets should be shared among the collaborators (once they obtain the full IRB approval), and hence lead to data minimization; and eventually (4) democratize genomic data sharing across researchers.

PI_NAMEs: AYDAY, ERMAN  (contact);JIANG, XIAOQIAN ;VAIDYA, JAIDEEP

PROGRAM_OFFICER_NAME: WANG, YANLI

PROJECT_TERMS: Acceleration;Address;Agreement;Algorithms;Collaborations;Computer software;computer studies;Data;data access;Data Collection;Data Pooling;Data Protection;Data Set;data sharing;Democracy;design;Disease;effective therapy;Ensure;Environment;Evolution;federated data;Generations;Genetic study;Genome;genome sciences;genome sequencing;genome wide association study;Genomic approach;genomic data;Genomics;Goals;Health;Heterogeneity;improved;Individual;insight;Institution;Institutional Review Boards;interest;Lead;Meta-Analysis;Metadata;Methods;Nature;Notification;novel;Outcome;Outcomes Research;Ownership;Participant;Personal Satisfaction;Pilot Projects;Policies;Population;Population Heterogeneity;Preparation;preservation;Preservation Technique;Privacy;privacy preservation;privacy protection;Privatization;Process;Publishing;Quality Control;Records;Reproducibility;Research;Research Personnel;Risk;Sampling;Secure;Site;Societies;software development;statistics;success;Techniques;tool;United States National Institutes of Health;Work

PROJECT_TITLE: Accelerating Genomic Data Sharing and Collaborative Research with Privacy Protection

STUDY_SECTION: BDMA

STUDY_SECTION_NAME: Biodata Management and Analysis Study Section[BDMA]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative The proposed K01 research will provide a framework for future Alzheimer’s disease (AD) prevention trials to intervene at an earlier point in the disease process than is currently possible with standard amyloid-beta (A)- PET approaches, increasing the feasibility of AD prevention rather than treatment to slow a neurodegenerative process that is already underway. A novel A-PET spatial extent approach will be developed that enables detection of the earliest focal A deposits below standard PET detection thresholds, allowing future trials to target individuals in the earliest stage of amyloidosis. This novel spatial extent approach will be used to examine the earliest changes in A spread, tau proliferation, and subtle cognitive decline, and establish optimized primary and secondary endpoints for clinical trials aiming to move closer to primary prevention.

PI_NAMEs: FARRELL, MICHELLE ELIZABETH (contact)

PROGRAM_OFFICER_NAME: ROVESCALLI, ALESSANDRA C

PROJECT_TERMS: abeta accumulation;abeta deposition;Acceleration;aging brain;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer’s disease biomarker;Amyloid beta-Protein;Amyloidosis;Binding;Biological Markers;Biometry;career;Clinical;Clinical Data;clinical translation;Clinical Trials;Clinical Trials Design;Cognition;Cognitive;cognitive change;cognitive testing;Communities;Complement;Computing Methodologies;Data;Dementia;Deposition;Detection;digital;Disease;Disease Progression;Drug Kinetics;Early Diagnosis;Evaluation;Exhibits;experience;follow-up;Future;glial activation;Growth;Heterogeneity;Impaired cognition;improved;in vivo;Individual;Inflammation;Intervention;Investigation;Learning;longitudinal positron emission tomography;Maps;Measures;medical schools;Mentors;Mentorship;Methods;multidisciplinary;Neocortex;Nerve Degeneration;Noise;novel;Outcome;Participant;Pathogenesis;Pathologic;Physics;Pittsburgh Compound-B;Plasma;Positron-Emission Tomography;pre-clinical;predictive marker;Predisposition;prevent;Prevention trial;Price;primary endpoint;Primary Prevention;Process;programs;Proliferating;radiotracer;Research;Risk;Role;Sampling;screening;secondary endpoint;Sensitivity and Specificity;simulation;Statistical Data Interpretation;statistics;Stereotyping;Symptoms;synaptic function;tau aggregation;tau Proteins;Testing;Training;translational potential;Translational Research;translational scientist;β-amyloid burden

PROJECT_TITLE: Optimizing PET spatial extent measures to detect the earliest amyloid-beta and tau accumulation and associated cognitive decline in preclinical Alzheimer's disease

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development For Early Career Investigators Study Section [AGCD-2]


NIH_SPENDING_CATS: Aging;Atherosclerosis;Biomedical Imaging;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Congenital Heart Disease;Congenital Structural Anomalies;Heart Disease;Heart Disease - Coronary Heart Disease;Hypertension;Orphan Drug;Pediatric;Prevention;Rare Diseases

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because delineation of the clinical benefits and mechanism of cardiovascular remodeling in patients with coarctation of aorta receiving angiotensin-II receptor blockers (ARB) will help develop novel management paradigms for prevention of left ventricular dysfunction and cardio- vascular death in this population, which will in turn save lives, reduce morbidity, and reduce healthcare costs. Successful completion of the proposed research in this application will provide strong justification for future multicenter clinical trials to determine the survival benefits of ARB and other classes of antihypertensive medi- cations in patients with repaired COA. The proposed research is relevant to the part of the NIH’s mission per- taining to the pursuit of knowledge to extend healthy life and reduce the burdens of illness and disability.

PI_NAMEs: EGBE, ALEXANDER  (contact)

PROGRAM_OFFICER_NAME: SCHWARTZ, BRYANNA NICOLE

PROJECT_TERMS: Adult;Adverse event;Aerobic;Age;Angiotensin II Receptor;Anti-Hypertensive Agents;Aorta;Aortic coarctation;Atherosclerosis;Blood Pressure;Blood Vessels;Borderline Hypertension;burden of illness;Cardiac;cardiac magnetic resonance imaging;Cardiac Output;cardiovascular disorder risk;Cardiovascular system;Cessation of life;Chronic;Clinical;cohort;congenital heart abnormality;Coronary;Coronary Arteriosclerosis;Data;Development;disability;Echocardiography;Exercise;Exhibits;extracellular;Fibrosis;Functional disorder;Future;Goals;Guidelines;Health Care Costs;Heart failure;hemodynamics;High Prevalence;Hypertension;hypertension control;hypertension treatment;hypertensive;Imaging Techniques;Impairment;improved;indexing;innovation;Knowledge;Left;Left Ventricular Dysfunction;Left Ventricular Remodeling;Life;Longevity;Losartan;Magnetic Resonance Imaging;Medical;Mission;Morbidity - disease rate;Multi-Institutional Clinical Trial;Myocardial Ischemia;novel;novel therapeutics;Operative Surgical Procedures;Outcome;Oxygen Consumption;Patients;Pharmaceutical Preparations;Physiologic intraventricular pressure;Placebos;Population;premature;pressure;prevent;Prevention;Public Health;Randomized;Recommendation;Relaxation;repaired;Research;response;Severities;Structure;sudden cardiac death;tau Proteins;Testing;Time;Translating;United States National Institutes of Health;Ventricular;Ventricular Dysfunction

PROJECT_TITLE: Clinical benefits and mechanism of action of angiotensin-II receptor blocker on Cardiovascular remodeling in patients with repaired coarctation of aorta

STUDY_SECTION: CCHS

STUDY_SECTION_NAME: Clinical Integrative Cardiovascular and Hematological Sciences Study Section[CCHS]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Pediatric;Pregnancy;Prevention;Rehabilitation;Social Determinants of Health;Women's Health Research

ORG_CITY: HACKENSACK

ORG_NAME: HACKENSACK UNIVERSITY MEDICAL CENTER

ORG_STATE: NJ

PHR: PROJECT NARRATIVE The overarching goal of the Enriching ECHO with High-risk Pregnancies and Children with Disabilities (Enriching ECHO) cohort is to advance disabilities inclusivity in ECHO research by studying children with a spectrum of disability and by leveraging existing data from ECHO participants with disabilities. Our scientific premise is that psychosocial environmental exposures (e.g., social determinants of health, stress, social environment, discrimination) and modifiable personal factors (e.g., parenting style, social supports, mental health) impact the physical and emotional health of children with disabilities resulting in definable outcomes of function, well-being, and participation in community and family life. Our hypothesis is that we can identify specific modifiable environmental factors associated with better-than-expected positive health outcomes along the continuum of disability to typical development that allow children with disabilities (and, by extension, all children) to thrive.

PI_NAMEs: ASCHNER, JUDY LYNN (contact);HAMVAS, AARON ;YEE, LYNN M

PROGRAM_OFFICER_NAME: LAESSIG, SUSAN ALISON

PROJECT_TERMS: adverse outcome;Affect;Behavioral;Biology;Birth;Birth Weight;Caregivers;Child;Child Health;Child Rearing;Child Welfare;Cognitive;cohort;Communities;community collaboration;Congenital Abnormality;Data;Data Collection;Data Element;design;Detection;Development;disability;Disabled Children;Disabled Persons;Discrimination;dissemination strategy;diversity and inclusion;Early identification;Emotional;Ensure;environmental enrichment for laboratory animals;Environmental Exposure;Environmental Risk Factor;equity, diversity, and inclusion;Exclusion;Family;Future;Goals;Health;health equity;high risk;High-Risk Pregnancy;improved outcome;insight;Intervention;Life;Longitudinal Studies;Mental Health;Mothers;Motor disability;Neuronal Plasticity;nutrition;offspring;Outcome;outcome prediction;Outcomes Research;Participant;Patient Recruitments;Perinatal;Personal Satisfaction;Physical activity;physically handicapped;Policies;Population;Positioning Attribute;postnatal;Pregnancy;Pregnancy Outcome;premature;prenatal;primary outcome;programs;Protocols documentation;psychosocial;public health relevance;Publications;recruit;Research Design;research study;resilience;retention rate;Sample Size;School-Age Population;Science;Scientific Advances and Accomplishments;Scientific Inquiry;Sensory;Sensory disabilities;Siblings;sleep health;Social Environment;social health determinants;Social support;Societies;Standardization;Stress;Surveys;Testing;Time;Underrepresented Populations;Visit

PROJECT_TITLE: Enriching ECHO Cohorts with High-risk Pregnancies and Children with Disabilities (Enriching ECHO)


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Rare Diseases;Tuberculosis

ORG_CITY: TEMPE

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

ORG_STATE: AZ

PHR: Project Narrative Men are less likely to complete TB treatment, contributing to their reduced life expectancy in South Africa. To address the paucity of interventions to improve men's TB outcomes, the proposed project will determine the feasibility of Coach Mpilo for men and assess secondary outcomes on treatment completion and viral suppression among HIV co-infected. Findings will provide essential information to support a larger effectiveness study in this setting.

PI_NAMEs: DANIELS, JOSEPH  (contact);MEDINA-MARINO, ANDREW

PROGRAM_OFFICER_NAME: MONGODIN, EMMANUEL FRANCK

PROJECT_TERMS: Address;Adherence;Adult;advocacy organizations;antiretroviral therapy;arm;Caring;Cities;Clinic;co-infection;Collaborations;Communities;community advisory board;Diagnosis;Disease;Effectiveness;effectiveness evaluation;effectiveness study;experience;Family;Feasibility Studies;Food;Friends;Future;Gender;gender disparity;Goals;Grant;Health;HIV;HIV/TB;Hybrids;improved;Intervention;Interview;Life Expectancy;Linguistics;male health;men;Methods;Modeling;motivational enhancement therapy;Outcome;Outcome Measure;peer support;Pilot Projects;Population;preference;Prevalence;primary outcome;Psyche structure;Randomized;Randomized, Controlled Trials;Reporting;Research;resilience;Resources;Safety;satisfaction;secondary outcome;service delivery;Sex Differences;simulation;skills;Social support;South Africa;Specific qualifier value;standard of care;Survivors;Symptoms;Techniques;Testing;therapy design;therapy development;Time;Training;treatment adherence;treatment comparison;Treatment outcome;trend;trial design;Tuberculosis;tuberculosis treatment;United States National Institutes of Health;usability;Viral;Viral Load result;willingness;Woman;Work

PROJECT_TITLE: Assessing the Feasibility of Coach Mpilo for Men with TB and HIV in Eastern Cape, South Africa

STUDY_SECTION: SSPT

STUDY_SECTION_NAME: NHLBI Single-Site and Pilot Clinical Trials Study Section[SSPT(MA)]


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Pediatric;Prevention

PHR: NARRATIVE The NIH has established the Environmental influences on Child Health Outcomes (ECHO) Program, a collaborative multi-dimensional research initiative to characterize the impact of early-life environmental factors (e.g., social-environmental, parental risk factors, nicotine, diet, infection) on childhood health. Vanderbilt will support ECHO by establishing the ECHO Laboratory Core at Vanderbilt for Integrated Sample Tracking and Processing (ELVIS), to facilitate the collection and processing of biospecimens; manage the biorepository; performs a wide range of biospecimen assays (including novel development), and coordinate metadata and assay data transfer to the Coordinating Center. Successful completion will enable the success of ECHO’s mission to discover molecular underpinnings of early childhood determinants of disease.

PI_NAMEs: DAS, SUMAN RANJAN (contact);FREEDMAN, JANE E;MALLAL, SIMON ALEXANDER;MCLEAN, JOHN ALAN;SHAH, RAVI

PROJECT_TERMS: Academic Medical Centers;Address;analysis pipeline;Architecture;Area;assay development;Basic Science;Behavioral;biobank;Bioinformatics;Biological;Biological Assay;Biological Markers;Biological Response Modifiers;Blood;Cells;Chemicals;Child Development;Child Health;Childhood;Clinical;Clinical Data;clinical research site;clinical translation;Cloud Computing;cohort;Collaborations;Collection;Complex;Cotinine;Data;Data Analyses;data analysis pipeline;Data Analytics;data exchange;data integration;data management;data sharing;Development;Diet;Dimensions;Disease;DNA;early childhood;early life exposure;Ensure;Environmental Exposure;Environmental Risk Factor;Epidemiology;Epigenetic Process;experience;Exposure to;Feces;Funding;Genetic;Genomics;Goals;Hair;Health;high throughput screening;Human Milk;Infection;Infrastructure;insight;Investments;Isoprostanes;Laboratories;Lead;Leadership;Life;Life Style;Link;Measures;member;metabolomics;Metadata;Metagenomics;Methods;microbiome;microbiome research;Mission;Molecular;multiple omics;Nail plate;Nicotine;Nose;novel;Nuclear;Nucleic Acids;Outcome;Participant;Pathogenesis;Patients;Performance;Perinatal;Placenta;Positioning Attribute;programs;Proteomics;Protocols documentation;Public Health;quality assurance;Research;Research Design;Research Personnel;Resource Sharing;Resources;response;Risk Factors;RNA;Running;sample collection;Sample Size;Sampling;Science;Secure;single-cell RNA sequencing;Site;social;success;System;Tissues;trait;transcriptome sequencing;transcriptomics;Translational Research;United States National Institutes of Health;Universities;Urine;Validation

PROJECT_TITLE: ECHO Laboratory Core at Vanderbilt for Integrated Sample Biobanking and Processing

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-EPH-G(51)R]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Nutrition;Obesity;Prevention;Primary Health Care;Social Determinants of Health

ORG_CITY: PROVIDENCE

ORG_NAME: MIRIAM HOSPITAL

ORG_STATE: RI

PHR: Project Narrative Poverty impacts over 37 million individuals in the U.S., putting them at risk for syndemics – clustered epidemics such as obesity, diabetes, and depression that arise from and perpetuate socioeconomic inequality. This application aims to mitigate syndemics by designing, delivering, and testing a fully automated online obesity treatment for those in poverty, working in partnership with primary care patients and providers. Given that 72.8% of adults in poverty have a primary care provider, and 82% have Internet access, this work has high potential for public health impact and findings will address a critical gap in scientific literature.

PI_NAMEs: CHOU, PO-HUN  (contact)

PROGRAM_OFFICER_NAME: SERRANO, KATRINA JANE

PROJECT_TERMS: Address;Adherence;Adoption;Adult;Affect;Aftercare;Behavioral;Body Weight decreased;Cardiovascular Diseases;career;Caring;Cause of Death;Characteristics;Clinical;Clinical Trials;Communities;community engaged research;Consolidated Framework for Implementation Research;cost;Data;Data Collection;Decision Making;Dementia;design;Development;Diabetes Mellitus;disadvantaged background;dissemination research;Effectiveness;Eligibility Determination;Epidemic;Face;Family;Feedback;Food;Funding;Goals;Health behavior;Health Priorities;Health Services Research;Healthcare;High Prevalence;implementation evaluation;implementation outcomes;implementation research;improved;Individual;insight;Internet;Intervention;intervention refinement;Knowledge;Link;Literature;Low income;Malignant Neoplasms;Measures;Mental Depression;Mental Health;Mentors;Methods;National Institute of Diabetes and Digestive and Kidney Diseases;Non-Insulin-Dependent Diabetes Mellitus;Nutritional;Obesity;obesity treatment;Outcome;Participant;Pathway interactions;patient population;patient retention;patient screening;Patients;Persons;Physical activity;physical conditioning;Population;Population Heterogeneity;Positioning Attribute;Poverty;Primary Care;primary care clinic;primary care patient;Primary Care Physician;primary care provider;Process;programs;prototype;Provider;Public Health;Readiness;Recommendation;recruit;Reduce health disparities;Research;Research Activity;Research Methodology;Research Personnel;research to practice;Resources;response;Rhode Island;Risk;Role;screening;Services;Severities;Site;social factors;social health determinants;Social Marketing;socioeconomic disadvantage;socioeconomic disparity;structural determinants;Structure;syndemic;Testing;theories;Time;tool;Training;treatment program;treatment research;Treatment/Psychosocial Effects;Underserved Population;United States National Institutes of Health;uptake;usability;Weight;weight loss program;Weight maintenance regimen;Work

PROJECT_TITLE: Adapting Online Obesity Treatment for Primary Care Patients in Poverty

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


NIH_SPENDING_CATS: Biomedical Imaging;Cardiovascular;Clinical Research;Congenital Heart Disease;Heart Disease;Patient Safety;Pediatric;Rare Diseases

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

PHR: PROJECT NARRATIVE Patients with mitral valve prolapse (MVP) are at increased risk of mortality related to the development of malignant ventricular arrhythmias, also known as Arrhythmic MVP, yet there are no pathognomonic features for accurate patient characterization and we lack strategies to reduce this risk. PET/MRI imaging has emerged as a novel strategy for the detection, quantification and localization of myocardial changes related to increased risk of ventricular arrhythmias including left ventricular replacement fibrosis and the preceding stage of inflammation. The goal of this study is to demonstrate how PET/MRI adds complementary and valuable information to the current assessment of patients with MVP and ideally results in improved arrhythmic risk stratification.

PI_NAMEs: ADAMS, DAVID H;FAYAD, ZAHI A.;MILLER, MARC ;TRIVIERI, MARIA GIOVANNA  (contact)

PROGRAM_OFFICER_NAME: EVANS, FRANK

PROJECT_TERMS: Address;Affect;Affinity;Arrhythmia;Biological Markers;Biopsy Specimen;Blood;Cardiac;cardiac magnetic resonance imaging;Cd68;Characteristics;Chronic;Cicatrix;circulating biomarkers;Clinical;Clinical Management;Clinical Research;cohort;Collection;Complex;coronary fibrosis;Cross-Sectional Studies;Data;Detection;Development;Disease;Disease-Free Survival;Echocardiography;Enrollment;Evaluation;Event;Fibroblasts;Fibrosis;fluorodeoxyglucose;fluorodeoxyglucose positron emission tomography;follow-up;Functional disorder;Future;Gadolinium;General Population;glucose metabolism;Goals;Guidelines;Heart Atrium;Heart failure;heart function;high risk;Histologic;Histology;Home;Hybrids;Image;image guided;improved;Incidence;Inflammation;Inflammatory;inflammatory marker;Investigation;Left;Left Ventricular Dysfunction;Left Ventricular Ejection Fraction;Location;longitudinal analysis;Macrophage;Magnetic Resonance Imaging;Malignant - descriptor;Measures;Mechanical Stress;Medical;Medical Records;Mitral Valve;Mitral Valve Insufficiency;Mitral Valve Prolapse;Modality;Monitor;Morphology;mortality risk;Myocardial;myocardial injury;Myocardium;Myofibroblast;novel;novel strategies;Operative Surgical Procedures;outcome prediction;papillary muscle;Patients;Pattern;Phase;Phenotype;Population Characteristics;Positron-Emission Tomography;Prevalence;primary endpoint;Process;PTPRC gene;Recommendation;Recording of previous events;Risk;Risk Reduction;risk stratification;Role;secondary analysis;secondary endpoint;Series;Serum;Severities;Signal Transduction;Stratification;Stroke;study characteristics;sudden cardiac death;Testing;Therapeutic;Time;Tracer;Traction;uptake;Ventricular;Ventricular Arrhythmia;Ventricular Tachycardia

PROJECT_TITLE: PET/MRI imaging of mitral valve prolapse


NIH_SPENDING_CATS: Behavioral and Social Science;Breastfeeding, Lactation and Breast Milk;Childhood Obesity;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Diabetes;Endocrine Disruptors;Estrogen;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Mental Health;Neurosciences;Nutrition;Obesity;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Physical Activity;Pregnancy;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: Oakland

ORG_NAME: KAISER FOUNDATION RESEARCH INSTITUTE

PHR: PROJECT NARRATIVE This study will continue following children enrolled in the national ECHO study. We will investigate the impact of environmental chemicals and maternal overnutrition factors on child obesity and neurodevelopment and identify potential mechanisms and factors that may mitigate adverse effects. Results will provide a better understanding of the developmental origins of child obesity and neurodevelopment and inform future interventions, prevention strategies and policies to reduce the burden of these common and costly childhood disorders and their long-term impact on health across the lifespan.

PI_NAMEs: CROEN, LISA A;FERRARA, ASSIAMIRA  (contact);HEDDERSON, MONIQUE MARIE

PROJECT_TERMS: Address;Adverse effects;Affect;Age;Appetite Regulation;autism spectrum disorder;Behavior;Behavioral;Birth;Body fat;Body mass index;Breast Feeding;career;Child;Child Health;Childhood;Clinical Research;cohort;Conceptions;cost;Data;Development;Diabetes Mellitus;Diet and Nutrition;dietary;disadvantaged background;Disease;DNA Methylation;early life exposure;Emotional;Endocrine Disruptors;Energy Intake;Enrollment;environmental chemical;Environmental Impact;epigenetic marker;Equity;Esters;ethnic diversity;Ethnic Population;evidence base;experience;Exposure to;Flame Retardants;follow-up;Future;Geographic Locations;Gestational Diabetes;gestational weight gain;Growth;Growth and Development function;Health;Health behavior;Human;Individual;Institution;Intervention;Joints;Lead;Leptin;life span;Life Style;Mediating;member;Mental Depression;metabolomics;Mothers;neurodevelopment;Obesity;obesity in children;Organophosphates;Outcome;Overnutrition;Participant;Pathway interactions;perceived discrimination;personalized intervention;Phase;Physical activity;Policies;Poly-fluoroalkyl substances;postnatal;prenatal;prenatal exposure;prenatal health;Prevention strategy;Process;Protocols documentation;Psychosocial Factor;Quality Control;Race;racial diversity;racial population;Recommendation;Research;Research Personnel;residential segregation;response;Role;Science;Serum;sex assigned;Sleep;social health determinants;Stress;trait;Unhealthy Diet

PROJECT_TITLE: Early Life Exposure to Endocrine Disrupting Chemicals and Child Growth, Adiposity, and Neurodevelopment


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: SAINT LOUIS

ORG_DEPT: NEUROLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Memory declines in Alzheimer’s disease (AD) develop before the onset of obvious clinical symptoms, but these changes are subtle and are often missed with conventional assessments that only measure memory over short periods of time. This project will develop and validate a smartphone-based memory assessment that extends memory testing to much longer and more realistic time periods. The ultimate goal is to incorporate this new assessment into ongoing clinical trials so that more sensitive tests are used to help determine the effectiveness of AD treatments.

PI_NAMEs: HASSENSTAB, JASON J (contact);WESTON, PHILIP

PROGRAM_OFFICER_NAME: LUO, YUAN

PROJECT_TERMS: Acceleration;Alzheimer's Disease;Alzheimer's disease risk;autosomal dominant Alzheimer's disease;autosomal dominant mutation;Books;Cellular Phone;Clinic;Clinical;clinical phenotype;Clinical Research;clinical trial readiness;Clinical Trials;Cognition;Cognitive;cognitive change;cognitive testing;Decentralization;Dementia;design;Development;digital;digital assessment;Digital biomarker;digital measure;Disease;disease phenotype;Distress;Effectiveness;effectiveness evaluation;Episodic memory;experience;Family member;Film;First Name;Floor;follow-up;forgetting;Genetic Risk;Goals;Hour;Human Resources;Impaired cognition;improved;Inherited;International;Laboratories;Learning;long term memory;Measurement;Measures;Memory;memory consolidation;Memory Loss;Methods;mild cognitive impairment;Mutation;mutation carrier;novel;Observational Study;older adult;Participant;Patients;Pattern;Persons;Phase;Pilot Projects;Population;Populations at Risk;prevent;Prevention trial;Process;Psychometrics;Quality of life;remote administration;remote grading;Research;Research Design;Signal Transduction;Source Code;Symptoms;technology development;Testing;Therapeutic Intervention;Time;verbal;Visit;Visual

PROJECT_TITLE: Digital Assessment of Long-term Forgetting in Autosomal-Dominant Alzheimer's Disease

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Coronaviruses;Emerging Infectious Diseases;Genetics;Infectious Diseases;Lung;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

PHR: PROJECT NARRATIVE This proposal investigates the negative impact of COVID-19 on the regenerative function of airway basal stem cells. Our findings promise to discover therapeutics to restore epithelium regeneration and reduce the risk for secondary infection in COVID-19.

PI_NAMEs: AI, XINGBIN  (contact)

PROGRAM_OFFICER_NAME: PLIMACK, MARY KATHERINE BRADFORD

PROJECT_TERMS: 2019-nCoV;acute infection;Acute respiratory infection;Age;Air;airway epithelium;alveolar type II cell;Animal Model;Antibodies;aspirate;ATAC-seq;Basal Cell;Biological Assay;Biopsy;Cell Cycle Arrest;Cell Line;Cell model;Cell Separation;Cell Survival;Cells;Cessation of life;chemokine;Chromatin;Chronic lung disease;Clinical Research;Contracts;Coronavirus;COVID-19;COVID-19 impact;cytokine;Defect;Derivation procedure;Disease;Endowment;epigenetic memory;Epigenetic Process;epithelial stem cell;Epithelium;epithelium regeneration;Exhibits;EZH2 gene;Foundations;Functional disorder;Future;Gene Expression;genetic approach;genetic signature;Genetic study;genomic locus;Goals;Health;Human;Hyperactivity;Immune;Impairment;imprint;In Vitro;in vivo;Infection;Inflammation;Inflammation Mediators;Inflammatory;Intubation;Lead;Liquid substance;Lower respiratory tract structure;Lung;Lung Diseases;Mediating;Mediator;Medical Waste;Memory;Methods;Microscopic;Modeling;Modification;Molecular;Morbidity - disease rate;mortality;multimodality;Mus;Natural Immunity;Olfactory Pathways;Organ;pandemic disease;pandemic influenza;pathogen;Pathogenesis;Pathway interactions;Patient Care;Patients;Phenotype;Play;prevent;Procedures;programs;Proliferating;receptor;regeneration function;Research;respiratory;Respiratory Disease;Respiratory Failure;Respiratory Tract Infections;response;Risk;Risk Reduction;Role;Sampling;SARS-CoV-2 infection;SARS-CoV-2 negative;secondary infection;senescence;Signal Transduction;single cell sequencing;Site;Skin;Source;Spanish flu;Stains;STAT3 gene;stem cell proliferation;stem cells;stemness;Testing;Therapeutic;therapeutic target;Trachea;transcription factor;transcriptome;United States;Viral Respiratory Tract Infection;Virus

PROJECT_TITLE: COVID-19 imprints airway basal cells to impair epithelium regeneration

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


ADMINISTERING_IC: EY

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Eye Disease and Disorders of Vision;Neurosciences;Social Determinants of Health

ORG_CITY: ITHACA

ORG_NAME: CORNELL UNIVERSITY

PHR: PROJECT NARATIVE Recognizing and responding to social cues is fundamental for health and wellbeing, though the developmental processes by which neural circuits supporting recognition are shaped is poorly understood. The proposed research leverages an invertebrate model of individual facial recognition, a paper wasp that also requires social experience for normal development of recognition. The ability to easily manipulate social experience coupled with the smaller brain and rapid development time of paper wasps will aid in discovering basic principles by which social experience modulates neural circuits.

PI_NAMEs: JERNIGAN, CHRISTOPHER M (contact)

PROGRAM_OFFICER_NAME: CLAYTON, EDWIN C

PROJECT_TERMS: Address;Adult;Affect;Age;Animals;Area;Award;Behavior;Behavioral;behavioral response;Brain;brain shape;brain volume;career;Cells;Central Nervous System;Classification;Color;Complex;Coupled;Cues;design;Detection;Development;Developmental Process;Dimensions;Discrimination;Electrophysiology (science);emerging adult;experience;experimental study;Eye;Face;Female;Future;Goals;Growth;Health;Human;Image;Individual;innovation;Invertebrates;Laboratory Study;Measures;Mediating;Memory;Modality;Modeling;Nervous System;neural;neural circuit;Neuroanatomy;Neurons;nonhuman primate;novel;older adult;Paper;Personal Satisfaction;Phase;Physiological;Population;Primates;Property;Research;response;Shapes;Siblings;social;social cognition;Social Development;Social Discrimination;Social Environment;social group;Social Identification;Social Interaction;Social isolation;Social Reinforcement;social relationships;Sorting;statistics;Synapses;System;Techniques;Temporal Lobe;Testing;Time;Training;Universities;Vision;Visual;visual stimulus;Wasps;Work

PROJECT_TITLE: Experience-dependent tuning of socially selective neural circuits


NIH_SPENDING_CATS: Genetics

ORG_CITY: TALLAHASSEE

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: FLORIDA STATE UNIVERSITY

ORG_STATE: FL

PHR: PROJECT NARRATIVE SUMOylation adds SUMO (a small polypeptide) to proteins, and polySUMOylation is a result of attachment of chains of SUMO. This project will investigate how polySUMOylation controls the relocation of key cell cycle regulators during the cell cycle and how this timely relocation contributes to genome stability. Because deregulation of SUMOylation leads to genome instability and cancer development, the results will likely provide new strategies for the treatment of cancer and other diseases.

PI_NAMEs: WANG, YANCHANG  (contact)

PROGRAM_OFFICER_NAME: MILLER, RITA K

PROJECT_TERMS: Affect;Anaphase;Biochemistry;biological adaptation to stress;cancer diagnosis;cancer therapy;Cell Cycle;Cell Physiology;Cell Proliferation;Cells;Cellular biology;chemical genetics;Chromosome Segregation;Chromosomes;Complex;Data;Development;Disease;DNA Damage;DNA Repair;Ensure;Eukaryota;Event;experimental study;Genome Stability;Genomic Instability;Goals;Human;Kinetochores;Knowledge;Lysine;Macromolecular Complexes;Malignant Neoplasms;Mitosis;Mitotic;Molecular;novel therapeutic intervention;Nuclear;Nucleolar Proteins;Outcome;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphotransferases;PLK1 gene;polypeptide;Post-Translational Protein Processing;prevent;Process;protein complex;protein function;Proteins;Regulation;repaired;Research;response;Ribosomal DNA;Role;Saccharomycetales;scaffold;Sumoylation Pathway;System;telophase;Testing;tool;Translating;treatment strategy;Ubiquitin;ubiquitin ligase;Ubiquitination;Work;yeast genetics;Yeasts

PROJECT_TITLE: Temporal-spatial control of mitotic regulators by polySUMOylation

STUDY_SECTION_NAME: Cell Structure and Function 1 Study Section[CSF1]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Childhood Obesity;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: MANHASSET

ORG_NAME: FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH

PHR: PROJECT NARRATIVE We will recruit 2,800 pregnant people, their partners, and their children into the EFFECT cohort to study how social and community influences before a child’s birth play a role in the development of child obesity. Our proposed cohort and study team are perfectly positioned to meet the current needs of the ECHO program: 1) to address solution-oriented scientific questions of high priority; 2) to increase the number of enrolled pregnant participants; 3) to facilitate the enrollment of the non-gestational parent; 4) to facilitate collection of preconception data; 5) to increase the racial, ethnic, and socioeconomic diversity of the ECHO cohort; and 6) to increase diversity in race, ethnicity, career stage, and professional background of the study team.

PI_NAMEs: ROCHELSON, BURTON ;STROUSTRUP, ANNEMARIE  (contact)

PROJECT_TERMS: Address;Adult;Advisory Committees;Age;Biological Markers;Birth;Body Composition;Body mass index;cardiometabolism;career;Caregivers;chatbot;Chemicals;Child;child bearing;Child Development;Child Health;Childhood;Clinical;cohort;Cohort Effect;Collection;Communication;Communities;community based participatory research;community engagement;Conceptions;Data;data management;Discipline of obstetrics;early childhood;early life exposure;Enrollment;Ensure;Environment;Environmental Exposure;Environmental Risk Factor;Environmental Science;Epidemiology;Ethnic Origin;Ethnic Population;experience;Exposure to;Family;fetal;Financial Hardship;Goals;Growth;Health system;in utero;infancy;innovation;Integrated Health Care Systems;intergenerational;Length;Life;Low income;maternal stress;Measures;minority children;minority communities;Minority Groups;Modeling;Morbidity - disease rate;mortality;New York;next generation;Obesity;obesity in children;obesity prevention;obesity risk;operation;Outcome;Overweight;Parents;Participant;patient engagement;patient population;Pediatric cohort;pediatric health outcomes;Persons;phthalates;Physiological;Play;Population;Positioning Attribute;Practice Management;Pregnancy;pregnant;prenatal exposure;Process;programs;prospective;Protocols documentation;psychosocial;Race;racial minority population;recruit;Research;research study;Risk Factors;Role;Science;Scientist;social;social health determinants;Social support;social vulnerability;socioeconomic diversity;Stressful Event;structural determinants;Surveys;Technology;Testing;Training;transmission process;United States;Weight

PROJECT_TITLE: The Environmental Factors in FEtal to Childhood Trajectories Cohort


NIH_SPENDING_CATS: Clinical Research;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention

PHR: Project Narrative The Developmental Impact of NICU Exposures (DINE) brings a unique and sensitive population with a demonstrated large burden of adverse health outcomes to the ECHO Pediatric Cohorts program. In this second phase of the ECHO program, we will continue to focus on the scientific premise that early life physical and chemical exposures, notably phthalates and air pollution, have long-lasting harmful effects on child health and development, particularly on pulmonary outcomes. We will also explore one of the central tenets of our work, that preterm infants can be studied to identify exposure-outcome links that may be more subtle in the general population, through the large ECHO cohort that enroll participants born over the entire preterm-to-term continuum.

PI_NAMEs: ASCHNER, JUDY LYNN;STROUSTRUP, ANNEMARIE  (contact)

PROJECT_TERMS: Abate;Address;Adolescent;adverse outcome;Age;Air Pollution;Area;Biological Specimen Banks;Birth;Bronchopulmonary Dysplasia;Caring;Chemical Exposure;Child;Child Development;Child Health;Child health care;Childhood Asthma;Clinical;Clinical Research;cohort;Consent;Data;Data Element;Data Set;Dedications;Dermal;Development;early childhood;early life exposure;Endocrine Disruptors;Enrollment;Environmental Exposure;experience;Exposure to;Face;Family;fetal;Funding;General Population;Goals;Health;Health Care Costs;High Prevalence;Hospitalization;infancy;Infant;Infrastructure;Inhalation;insight;interest;Intravenous;Investigation;Life;Life Cycle Stages;Link;Longterm Follow-up;Lung;middle childhood;Neonatal Intensive Care Units;novel;Outcome;Participant;participant enrollment;participant retention;Pediatric cohort;pediatric health outcomes;Persons;Phase;Phenotype;phthalates;Population;Pregnancy;Pregnant Women;Premature Birth;Premature Infant;Procedures;programs;Protocols documentation;pulmonary function;Research;Risk;Site;societal costs;Third Pregnancy Trimester;United States;Visit;Work

PROJECT_TITLE: Developmental Impact of NICU Exposures (DINE) phase II


NIH_SPENDING_CATS: Clinical Research;Genetics;Infectious Diseases;Lung;Neonatal Respiratory Distress;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period

ORG_CITY: HERSHEY

ORG_NAME: PENNSYLVANIA STATE UNIV HERSHEY MED CTR

ORG_STATE: PA

PHR: Narrative Respiratory syncytial virus (RSV) causes significant morbidity and mortality in infants with a global disease burden of 64 million cases and 160,000 deaths with healthcare costs estimated at $365-$585 million per year. The objective of the current research proposal is to elucidate the role of human SP-A genetic variant and sex in RSV severity and to get insight into the mechanisms of host factors that govern the severity of RSV disease. This will lead to the development of novel approaches and individualized therapeutic options for severe RSV infection.

PI_NAMEs: GANDHI, CHINTAN K (contact)

PROGRAM_OFFICER_NAME: REYES, MADELYN

PROJECT_TERMS: adaptive immunity;Adult;Age;Alveolar;Alveolar Macrophages;Anti-viral Agents;Anti-viral Response;Asthma;Award;Binding;Biological Assay;Biology;Bronchoalveolar Lavage;burden of illness;career development;Cells;Cessation of life;Child;comparison control;cost estimate;Data;Development;Developmental Biology;Disease;Ensure;Evolution;experience;Experimental Models;Female;Flow Cytometry;Functional disorder;Funding;Future;General Population;Genes;Genetic;genetic variant;genotypic sex;Health Care Costs;Host Defense;Human;humanized mouse;Imaging Techniques;Immune;Immune system;Immunology;improved;in vivo;Infant;Infant Mortality;Infection;Inflammation;Inflammatory;Inflammatory Response;Innate Immune Response;innovation;insight;Integration Host Factors;interstitial;Knock-out;Knowledge;Life;Lung;lung preservation;Macrophage;male;Mediating;meetings;Mentorship;Microscopic;Microscopy;Molecular Biology;Monitor;Morbidity - disease rate;mortality;mouse model;multidisciplinary;Mus;Natural Immunity;Neonatal;neonatal infection;Neonatal lung;neonatal lung disease;neonatal mice;neonatal respiration;neonate;Neonatology;neutrophil;new therapeutic target;novel;novel strategies;Outcome;Pathogenesis;Pathway interactions;personalized therapeutic;Phagocytes;Phase;Phenotype;Physicians;Play;Predisposition;Proteins;Protocols documentation;pulmonary function;Pulmonary Surfactant-Associated Protein A;pup;receptor;Reporting;Research;Research Personnel;Research Proposals;Respiration;respiratory;Respiratory syncytial virus;Respiratory Syncytial Virus Infections;Respiratory Therapy;Respiratory Tract Infections;response;Risk;Risk Factors;Role;Scientist;Severities;sex;Sex Differences;Signal Transduction;skills;spatiotemporal;Stimulus;success;surfactant protein A receptor;Testing;Therapeutic;Therapeutic Effect;therapeutic target;Training;transcriptome;Transgenic Organisms;translational scientist;vaccine access;Vaccines;Variant;Viral;Viral Pathogenesis;virology;Virus;Virus Diseases;Wild Type Mouse;women versus men

PROJECT_TITLE: The role of surfactant protein-A genetic variant and sex in pathogenesis of neonatal respiratory syncytial virus infection


NIH_SPENDING_CATS: Brain Disorders;Cardiovascular;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Heart Disease;Hematology;Neurosciences;Prevention;Stroke

ORG_CITY: CHICAGO

ORG_DEPT: SURGERY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: Project Narrative Chronic, daily, oral anticoagulation reduces the risk of stroke in patients with atrial fibrillation but increases the risk of hemorrhage, including fatal hemorrhage, even during long periods of sinus rhythm when the risk of cardioembolic stroke is low. This study will compare the current standard of care of continuous anticoagulation with a novel approach of targeted, time-delimited anticoagulation therapy guided by an AF-sensing smartwatch. If successful, this paradigm shift toward individualized or “precision” stroke prevention could reduce anticoagulant use, hemorrhage risk, healthcare utilization and cost for millions of AF patients worldwide.

PI_NAMEs: PASSMAN, ROD S (contact)

PROGRAM_OFFICER_NAME: KETEMA, FASSIL

PROJECT_TERMS: Anticoagulants;Anticoagulation;Apple watch;Area;Arrhythmia;Atrial Fibrillation;Benefits and Risks;Blinded;Blood Cells;Caring;Chronic;Clinical;Clinical Trials;comparative efficacy;Compartment syndromes;cost;design;efficacy evaluation;Elements;Embolism;Erythrocytes;Evaluation;Event;evidence base;experimental arm;Exposure to;falls;Goals;Health;health care service utilization;Hemoglobin concentration result;Hemorrhage;Hemostatic function;high risk;Hour;improved;innovation;International;Intramuscular;Ischemic Stroke;Monitor;mortality;novel;novel strategies;open label;Oral;Organ;Outcome;Participant;Patients;Pericardial body location;Phase;precision medicine;prospective;Quality of life;Randomized;Reaction;Recording of previous events;Resources;response;Retroperitoneal Space;Risk;Risk Reduction;Safety;satisfaction;Sinus;smart watch;Societies;standard of care;Stroke;Stroke prevention;stroke risk;Technology;Testing;Therapeutic;Thrombosis;Time;Transfusion;treatment strategy;trial comparing;two-arm study;Vision;wearable device;Whole Blood

PROJECT_TITLE: The Rhythm Evaluation for Anticoagulation with Continuous Monitoring of Atrial Fibrillation Trial (REACT-AF)

STUDY_SECTION_NAME: Clinical Trials Review Study Section[CLTR(MA)]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Pediatric;Prevention;Primary Health Care;Social Determinants of Health

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: NARRATIVE Poverty and racism result in increased adverse childhood experiences (ACEs) and decreased positive childhood experiences (PCEs), which is associated with disparities in early child development (ECD) that begin early in life, widen as children age, and persist across the lifespan. Evidence-based preventive interventions (EBPIs) located in pediatric primary care and designed to reduce these disparities have shown some evidence of impact in addressing ACEs or supporting PCEs in insolation, but they have been limited because they fail to address both concurrently and directly, and because knowledge related to dissemination and implementation (D&I) is limited. This study proposes to identify best practices to implement integrated EBPIs, and to evaluate a novel integration of two exemplar, AAP-recommended EBPIs, HealthySteps and Video Interaction Project, in order to: 1) support wide D&I of co-located services; and 2) provide population-level impacts in reducing ECD disparities.

PI_NAMEs: CANFIELD, CAITLIN FORD (contact);MILLER, ELIZABETH B.

PROGRAM_OFFICER_NAME: PADGETT, LYNNE SLAUGHTER

PROJECT_TERMS: Academic skills;Academy;Address;adverse childhood events;Affect;Age;American;Books;Buffers;Caring;Child;Child Development;Child Health;Child health care;Child Rearing;Childhood;Cities;Cognitive;collaborative care;contextual factors;cost;depressive symptoms;design;Developmental Delay Disorders;Disparity;disparity reduction;Dissemination and Implementation;Effectiveness;effectiveness evaluation;effectiveness outcome;effectiveness/implementation study;Elements;ethnic minority;evidence base;evidence based guidelines;Evidence based intervention;experience;Family;Feedback;flexibility;Health;health disparity;Healthcare;Home environment;Hybrids;implementation outcomes;implementation/effectiveness;improved;Inequality;Informal Social Control;intervention delivery;Investments;Knowledge;learning materials;Life;life span;Link;Low income;maternal depression;Mediating;Mental Health;Methods;Modeling;National Institute on Minority Health and Health Disparities;novel;Outcome;Parent-Child Relations;parenting intervention;Parents;Pathway interactions;Pediatrics;physical conditioning;Play;Population;Poverty;preference;preventive intervention;Primary Care;programs;racial minority;racism;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Readiness;Reading;Recommendation;Reduce health disparities;Resources;Schools;screening;Services;Site;social;standard of care;stem;Stress;Structure;Testing;therapy design;Time;Toy;Trust;Video Recording;Visit;Well Child Visits;Well in self

PROJECT_TITLE: Enhancing Early Relational Health to Reduce Disparities in Child Health and Development: Addressing ACEs and Promoting PCEs through an Integrated Evidence-based Intervention in Pediatric Primary Care

STUDY_SECTION: HHD

STUDY_SECTION_NAME: Healthcare and Health Disparities Study Section[HHD]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Nutrition

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: NARRATIVE Diabetes is a leading cause of morbidity and mortality worldwide, and is on the rise. The role of different nutrients in diabetes is poorly understood. We have uncovered here a novel mechanism that links a specific class of nutrients, branched chain amino acids, to diabetes and to blood pressure, and we propose experiments to understand the process in molecular and physiological detail, in order to determine if and how targeting this pathway may have therapeutic potential.

PI_NAMEs: ARANY, ZOLTAN P (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Acids;Address;Affect;Alleles;Aorta;Biological Assay;Biology;Biotechnology;Blinded;blood glucose regulation;Blood Pressure;blood pressure reduction;Blood Vessels;Branched-Chain Amino Acids;Cardiovascular system;Catabolism;Clinical;Complex;Cross-Over Studies;Data;Diabetes Mellitus;diabetic;Diet;Endothelial Cells;epidemiology study;experimental study;Fatty acid glycerol esters;FRAP1 gene;Funding;gain of function;Genes;Genetic;Glucose Clamp;glucose disposal;glucose tolerance;glucose uptake;GLUT 4 protein;Homeostasis;Human;Human Volunteers;Hyperinsulinism;improved;in vivo;inhibitor;insight;Insulin;Insulin Resistance;interest;Kidney Failure;Laboratories;Light;Link;Literature;Liver;loss of function;Mediating;Metabolic;Metabolism;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;Muscle;Myography;Negative Finding;Nitric Oxide;Nitrogen;Non-Insulin-Dependent Diabetes Mellitus;novel;Nutrient;Pathology;Pathway interactions;Patients;Pharmacologic Substance;Phosphorylation;Physiological;Physiology;Placebo Control;Plasma;Process;Production;Protein Dephosphorylation;response;Role;Series;Signal Transduction;Site;Skeletal Muscle;Smooth Muscle;Smooth Muscle Myocytes;success;Telemetry;Testing;Therapeutic;Time;Vasodilation;volunteer

PROJECT_TITLE: Keeping fat out of muscle - Role of Branched Amino AcidsAmino Acids in Insulin Resistance

STUDY_SECTION: CSME

STUDY_SECTION_NAME: Cell Signaling and Molecular Endocrinology Study Section[CSME]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Data Science;Dementia;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Primary Health Care

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

PHR: PROJECT NARRATIVE/LAY STATEMENT Patients with Alzheimer’s disease and related dementias (ADRD) require effective coordination to manage numerous longitudinal care needs including diagnosis, exacerbation of symptoms, and to treat existing comorbidities. Supporting primary care providers to manage and coordinate healthcare delivery among specialist teams is important to improve outcomes and better quality of life for patients with ADRD. The goal of this project is to develop approaches that monitor trends in care coordination among primary care providers and specialist teams and recommend actionable opportunities for improvement, which will ensure that patients receive high- quality multidisciplinary care necessary to maintain long-term wellbeing.

PI_NAMEs: STEITZ, BRYAN  (contact)

PROGRAM_OFFICER_NAME: DUAN, LEWEI

PROJECT_TERMS: Abnormal coordination;Academic Medical Centers;acute care;Address;Aging;Alzheimer's disease patient;Alzheimer's disease related dementia;Area;care coordination;care fragmentation;career;Caregiver support;Caregivers;Caring;Classification;Client satisfaction;Clinical;Clinical Management;Collaborations;collaborative care;Communication;comorbidity;Complex;Data;data communication;Data Science;dementia care;Diagnosis;Disease;Early Diagnosis;Electronic Health Record;Ensure;Environment;explainable machine learning;Failure;Goals;health care delivery;health care service;health management;Health Personnel;Health Services Research;Healthcare;healthy aging;improved;improved outcome;information organization;Information Sciences;innovation;insight;K-Series Research Career Programs;Knowledge;Learning;longitudinal care;Machine Learning;machine learning model;Measures;Medical Care Team;medical specialties;member;Mentors;Mentorship;Mining;Modeling;Monitor;multidisciplinary;Natural Language Processing;Nature;neglect;novel;older adult;Pathway Analysis;Pathway interactions;Patient Care;Patient Care Management;patient portal;Patients;Pattern;Patterns of Care;Personal Satisfaction;Positioning Attribute;Primary Care;primary care provider;Principal Investigator;Process;programs;Provider;Quality of life;Randomized, Controlled Trials;Recommendation;Research;Research Personnel;Resources;Social Network;Specialist;Statistical Methods;Statistical Models;Structure;Suggestion;Symptoms;System;Taxonomy;team-based care;Techniques;Time;Training;treatment and outcome;trend;Work

PROJECT_TITLE: Integrative Data Science Approach to Advance Care Coordination of ADRD by Primary Care Providers


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Anxiety Disorders;Brain Disorders;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Mental Health;Mental Illness;Post-Traumatic Stress Disorder (PTSD);Racial and Ethnic Minority Health Research

ORG_CITY: CAMBRIDGE

ORG_NAME: BROAD INSTITUTE, INC.

PHR: PROJECT NARRATIVE Progress has been made in identifying genetic risk factors for PTSD. However, the under-representation of African populations in PTSD genetic research risks widening existing research and treatment disparities for such populations. The goal of this proposal is to accelerate genetic discovery for PTSD by addressing the under- representation of African populations in PTSD genetic research through a unique U.S. – African partnership which includes large-scale data collection, the long-term goal is to ensure the genomics revolution in psychiatry benefits future generations of Africans.

PI_NAMEs: AKENA, DICKENS HOWARD;ATWOLI, LUKOYE ;FATUMO, SEGUN ;KOENEN, KARESTAN C (contact);NIEVERGELT, CAROLINE M

PROGRAM_OFFICER_NAME: PEVSNER, JONATHAN ABRAM

PROJECT_TERMS: Acceleration;Address;Africa;African;African ancestry;Alleles;biobank;causal variant;Chromosome Mapping;cohort;Copy Number Polymorphism;Data;Data Collection;data integration;Disease;electronic health data;Electronic Health Record;Elements;Enrollment;Ensure;Equity;European ancestry;Freezing;Funding;Future Generations;gene discovery;Genes;Genetic;genetic architecture;Genetic Databases;Genetic Markers;Genetic Research;genetic risk factor;Genetic study;Genome;genome resource;genome wide association study;genome-wide;genome-wide analysis;Genomics;Goals;Haplotypes;health inequalities;improved;Individual;Inequality;Inequity;Institution;Investments;Kenya;large scale data;Linkage Disequilibrium;Maps;Measures;meetings;Mental disorders;Meta-Analysis;multi-ethnic;National Institute of Mental Health;neuropsychiatry;non-genomic;novel therapeutics;Participant;Performance;Persons;polygenic risk score;Population;Population Heterogeneity;Population Programs;Post-Traumatic Stress Disorders;psychiatric genomics;Psychiatry;rare variant;Recontacts;Research;Research Personnel;Resources;Risk;risk prediction;risk variant;Sample Size;Sampling;Scientific Advances and Accomplishments;Signal Transduction;Single Nucleotide Polymorphism;Strategic Planning;success;Time;Trauma;treatment disparity;Uganda;Variant;Work;working group

PROJECT_TITLE: Genetics of PTSD in African Ancestry Populations: Enhancing discovery by addressing inequality

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-EPH-C(02)M]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Physical Activity;Prevention

ORG_CITY: ORLANDO

ORG_NAME: ADVENTHEALTH ORLANDO

PHR: NARRATIVE In this 5-year follow-up to the IGNITE exercise intervention study we will examine whether exercise has a delayed or protracted benefit to neurocognitive outcomes including Alzheimer’s disease neuropathology. We will also examine whether we can predict long-term exercise engagement by utilizing the rich biological and psychological data from IGNITE.

PI_NAMEs: ERICKSON, KIRK I (contact)

PROGRAM_OFFICER_NAME: WAGSTER, MOLLY V

PROJECT_TERMS: actigraphy;active control;active control group;active lifestyle;Address;Adherence;Adult;Aerobic Exercise;Age Years;Age-associated memory impairment;Alzheimer's Disease;Amyloid beta-42;arterial stiffness;Attenuated;Behavior;Binding;Biological;Biological Assay;blind;Blood;Body Composition;Brain;brain health;brain morphology;cardiometabolism;cardiorespiratory fitness;cerebral atrophy;Cerebrovascular Circulation;Characteristics;Cognition;Cognitive;cognitive benefits;cognitive function;cognitive performance;cost effective;cytokine;Data;dementia risk;design;Dose;Evaluation;Exercise;exercise intensity;exercise intervention;Exercise Therapy;expectation;follow-up;Functional Magnetic Resonance Imaging;Funding;Future;Genetic;Hippocampus;improved;Inflammatory;Intervention;Intervention Studies;Intervention Trial;Lesion;light intensity;Machine Learning;Magnetic Resonance Imaging;Maintenance;Measures;Mediating;Mediator;Moods;neural;Neurocognition;Neurocognitive;neuroimaging marker;Neuronal Plasticity;neuropathology;neurotrophic factor;Outcome;Participant;Pathway interactions;Personality;Physical activity;Physical Fitness;Physical Function;Physiological;Positron-Emission Tomography;Predictive Factor;Prefrontal Cortex;primary endpoint;psychologic;Psychosocial Factor;Public Health;Randomized;randomized, clinical trials;Recommendation;Research Personnel;response;Rest;Sample Size;Science;secondary endpoint;Site;Sleep;Social Network;Socioeconomic Status;Structure;Testing;treatment group;Underrepresented Minority;United States National Institutes of Health;VO2max;white matter;β-amyloid burden

PROJECT_TITLE: Examining the Persistence of Neurocognitive Benefits of Exercise

STUDY_SECTION: HCMF

STUDY_SECTION_NAME: Human Complex Mental Function Study Section[HCMF]