NIH_SPENDING_CATS: Biomedical Imaging;Brain Disorders;Clinical Research;Epilepsy;Neurodegenerative;Neurosciences

PHR: Project Narrative Echo planar fMRI is widely used at our institution, and others, for functional localization for patients who are candidates for surgical resection to treat epilepsy. This project will develop and assess accurate, real-time, self-navigated slice-by-slice motion monitoring, retrospective and prospective motion correction strategies to substantially improve the quality of fMRI. These new sophisticated technological advances will enable the reduction of the duration of fMRI scans, and ensure the collection of sufficient high quality data free of motion artifact which in turn will enable improved localization of function. These advances will ultimately increase the quality and utility, and decrease the cost, of fMRI for planning the effective use of surgery to cure epilepsy.

PI_NAMEs: WARFIELD, SIMON K (contact)

PROGRAM_OFFICER_NAME: WHITTEMORE, VICKY R

PROJECT_TERMS: Affect;Benefits and Risks;Brain;Childhood;Clinical;clinical practice;cohort;Collection;Compensation;Computer software;cost;curative treatments;Data;design;efficacy evaluation;Elderly;Elements;Ensure;Epilepsy;Excision;Feedback;Functional Magnetic Resonance Imaging;functional MRI scan;Head;Head Movements;Image;imaging study;improved;Individual;individual patient;Institution;Instruction;Intractable Epilepsy;Magnetic Resonance Imaging;Measures;Monitor;Morphologic artifacts;Motion;neurosurgery;new technology;Noise;novel;Operative Surgical Procedures;Outcome Assessment;Outcome Measure;Participant;Patients;Performance;Persons;Pharmacotherapy;Physiologic pulse;Play;Positioning Attribute;programs;prospective;Recording of previous events;recruit;Risk Assessment;Role;Scanning;Series;Signal Transduction;simulation;Slice;Techniques;Technology;Time;Training;volunteer

PROJECT_TITLE: Motion Compensated fMRI for Pre-Surgical Planning in Epilepsy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-NV-Q(91)S]


ADMINISTERING_IC: GM

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: CHAMPAIGN

ORG_COUNTRY: UNITED STATES

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

ORG_STATE: IL

PHR: Our first Aim is to dissect both transcription independent and transcription dependent mechanisms for genome positioning relative to nuclear speckles. Our second Aim is to map, visualize, reconstitute, and then dissect cis and trans determinants for large-scale chromatin domains with distinct levels of compaction. These two Aims address fundamental yet novel aspects of gene regulation.

PI_NAMEs: BELMONT, ANDREW STEVEN (contact)

PROGRAM_OFFICER_NAME: VATAKIS, DIMITRIOS NIKOLAOS

PROJECT_TERMS: Address;Bacterial Artificial Chromosomes;Binding;Biological Assay;Biological Process;Biomedical Research;Cell Nucleus;Cells;Chromatin;Chromatin Fiber;Chromosomes;COL1A1 gene;Cytology;Development;Dissection;DNA;DNA Sequence;domain mapping;Electron Microscopy;Elements;Engineering;Ensure;experimental study;Funding;gene discovery;Gene Expression;Gene Expression Regulation;Gene Order;Gene Transfer Techniques;Genes;Genetic Transcription;Genome;genome-wide;Genomic Segment;Genomics;Goals;Grant;Hi-C;HSF1;In Situ Hybridization;Interphase Chromosome;Lead;light microscopy;live cell microscopy;Maps;Measures;Methods;Molecular;novel;Nuclear;Output;Pathway interactions;Positioning Attribute;preservation;Promoter Regions;Proteins;reconstitution;recruit;Repression;Resolution;Structure;Technology;Transcription Coactivator;Transcription Elongation;transcription factor;Transcription Initiation;Transcriptional Activation;Transcriptional Regulation;Transgenes;Visualization;Work

PROJECT_TITLE: Chromatin Domain Structure and Function

STUDY_SECTION: NCSD

STUDY_SECTION_NAME: Nuclear and Cytoplasmic Structure/Function and Dynamics Study Section[NCSD]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;Digestive Diseases;Genetics;Hepatitis;Hepatitis - C;Immunization;Infectious Diseases;Liver Disease;Prevention;Vaccine Related

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PI_NAMEs: BARNES, ELEANOR  (contact)

PROJECT_TERMS: Acute;Address;Adenovirus Vector;Adjuvant;anti-hepatitis C;Antibody Response;Antigens;antiviral immunity;B-Lymphocytes;Bioinformatics;booster vaccine;CD8-Positive T-Lymphocytes;chronic infection;Cicatrix;Clinical Trials;Conserved Sequence;COVID-19 vaccine;cross reactivity;Data;design;Detection;Development;E protein;efficacy trial;Epitopes;Future;Genetic;Genetic Variation;Genotype;Goals;Head;Hepatitis C;Hepatitis C Antibodies;Hepatitis C Antiviral;Hepatitis C Vaccine;Hepatitis C virus;HLA A*0201 antigen;HLA Antigens;HLA-A3 Antigen;Human;humanized mouse;Immune response;Immunity;Immunization;immunogenic;immunogenicity;Immunology;in silico;Inbreeding;Individual;Infection;Infection prevention;invariant chain;Length;Link;Liver;Macaca mulatta;Malignant Neoplasms;Mediating;memory recall;Methods;Modeling;Modified Vaccinia Virus Ankara;mosaic;Mus;nanoparticle;neutralizing antibody;nonhuman primate;novel;novel strategies;novel vaccines;Pan Genus;particle;Persons;pre-clinical;pre-clinical assessment;preclinical study;prevent;Primary Infection;Proteins;Proteome;Regimen;secondary infection;T cell response;T memory cell;T-Cell Depletion;T-Lymphocyte;T-Lymphocyte Epitopes;Testing;tool;transgene expression;Transgenic Mice;Vaccination;vaccination strategy;vaccine candidate;Vaccine Design;vaccine immunogenicity;vaccine strategy;Vaccines;Variant;vector;vector vaccine;Viral;viral RNA;Viral Vector;virus envelope;virus genetics;World Health Organization

PROJECT_TITLE: The development and pre-clinical assessment of novel HCV vaccines to generate T and B cell immunity


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Immunization;Immunotherapy;Infectious Diseases;Prevention;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation;Vaccine Related

ORG_CITY: DUARTE

ORG_NAME: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE

ORG_STATE: CA

PHR: PROJECT NARRATIVE Our promising pilot data suggests that donor vaccination could substitute for 100 days of Prevymis prophylaxis to control CMV reactivation and disease. We will investigate vaccination of the stem cell donor as an alternative to the stem cell recipient to better control early CMV reactivation events or those associated with steroid use in the recently completed Phase 2 randomized clinical trial. To extend the value of Triplex vaccination to the higher risk haploidentical stem cell transplant setting where there can be as many as three HLA mismatches, we will conduct a Phase 1b/2 trial in which we hypothesize that both early and late reactivation will be controlled by vaccination of both the donor and the recipient with minimal or no Prevymis prophylaxis.

PI_NAMEs: DIAMOND, DON J (contact)

PROGRAM_OFFICER_NAME: OLKHANUD, PUREVDORJ BALJINNYAM

PROJECT_TERMS: Acceleration;Acute;Adoption;Adoptive Transfer;Adult;Anti-viral Agents;Antigens;arm;Blinded;CD4 Positive T Lymphocytes;CD8B1 gene;Chronic;Clinical Research;clinically significant;Collaborations;Cyclophosphamide;Cytomegalovirus;Data;design;Disease;donor stem cell;Dose;Double-Blind Method;Eligibility Determination;Enrollment;Event;Frequencies;Gene Expression;Goals;healthy volunteer;Hematocrit procedure;Hematologic Neoplasms;Hematopoietic Stem Cell Transplantation;high risk;immune reconstitution;Immune response;Immunity;Immunocompetence;Immunocompetent;Immunodominant Antigens;immunogenicity;Immunotherapy;improved;In complete remission;Incidence;Infusion procedures;Injections;Measurement;Measures;Medical center;Memory;Modified Vaccinia Virus Ankara;Names;novel therapeutics;open label;Outcome;Patients;Performance;Phase;phase 2 study;Phase Ib Clinical Trial;Phase Ib Trial;Phase Ib/II Trial;Phase II Clinical Trials;phase II trial;phase III trial;Phenotype;Pilot Projects;pilot trial;Placebo Control;Placebos;Population;prevent;primary endpoint;Property;Prophylactic treatment;Publishing;Randomized;randomized placebo controlled trial;randomized, clinical trials;Recombinants;reconstitution;Regimen;Resistance;Risk;Safety;safety study;secondary endpoint;Side;standard of care;Stem cell transplant;stem cells;Steroids;T-Lymphocyte;Testing;Therapeutic;Time;Toxic effect;Transplant Recipients;underserved minority;Vaccinated;Vaccination;vaccination strategy;vaccine immunogenicity;vaccine strategy;vaccine-induced immunity;Vaccines;Viral;Viremia

PROJECT_TITLE: Transfer of vaccine-induced immunity from immunocompetent stem cell donor as antiviral immunotherapy to protect high-risk transplant recipients from cytomegalovirus reactivation

STUDY_SECTION: CONC

STUDY_SECTION_NAME: Clinical Oncology Study Section[CONC]


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Aging;Chronic Pain;Clinical Research;Health Services;Pain Research;Patient Safety;Telehealth;Urologic Diseases

ORG_CITY: CHICAGO

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: Project Narrative The goal of this project is to use novel patient-reported outcomes to improve the clinical care of patients with urinary symptoms that are secondary to benign prostatic hyperplasia. The use of new patient-centered tools will improve evaluation and clinical decision-making by including symptoms not commonly measured in men, such as urinary incontinence, and allow for more frequent assessment of lower urinary tract symptoms and other non-urologic symptoms through remote surveillance. Through the use of care-coordination checklists, clinicians can be more responsive to post-treatment symptom changes, resulting in reduced bother from lower urinary tract symptoms and higher quality of life in patients with benign prostatic hyperplasia.

PI_NAMEs: GLASER, ALEXANDER PAUL;GRIFFITH, JAMES WILLIAM (contact);SMITH, ABIGAIL

PROGRAM_OFFICER_NAME: KIRKALI, ZIYA

PROJECT_TERMS: Address;Aftercare;American;Anxiety;associated symptom;Benign Prostatic Hypertrophy;Bladder;bladder pain;care coordination;Caring;Clinic;Clinical;clinical care;clinical decision-making;clinical practice;comorbidity;Complex;cost effective;Counseling;Data;design;Diagnosis;Dimensions;Distress;effective therapy;Electronic Health Record;Evaluation;Evidence based treatment;experience;Extravasation;follow-up;Functional disorder;Global Change;Goals;Guidelines;Health;improved;Incontinence;indexing;instrument;Intervention;intravesical;Language;Lower urinary tract;lower urinary tract symptoms;Malignant neoplasm of prostate;Measures;Medical;men;Mental Depression;Methods;Mind;Modeling;Modernization;Monitor;novel;Nurses;Operative Surgical Procedures;Outcome Assessment;Overactive Bladder;Pain;Patient Care;patient oriented;Patient Outcomes Assessments;Patients;persistent symptom;Phase;Physician Assistants;Population;postoperative recovery;Property;Prostate;Prostatic;Provider;Psychometrics;Qualitative Methods;Quality of Care;Quality of life;Questionnaires;Recommendation;Recovery;reduce symptoms;Research;Risk Factors;screening;Secondary to;Severities;side effect;Sleep disturbances;Statistical Methods;Surgical Management;Symptom Burden;symptom treatment;Symptoms;Technology;telehealth;Telemedicine;Testing;Time;tool;treatment as usual;treatment response;Update;urinary;Urinary Incontinence;Urinary tract infection;urologic;Urology;Work

PROJECT_TITLE: Enhanced Clinical Decisions for Management of Benign Prostatic Hyperplasia Using Patient-Reported Outcomes

STUDY_SECTION: KUFD

STUDY_SECTION_NAME: Kidney and Urological Systems Function and Dysfunction Study Section[KUFD]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Aging;Assistive Technology;Atherosclerosis;Bioengineering;Biotechnology;Cardiovascular;Heart Disease;Kidney Disease;Precision Medicine;Prevention

ORG_CITY: DALLAS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: Project Narrative Patients with end-stage renal disease on hemodialysis have frequent hospitalizations and poor survival, due in large part to cardiovascular disease: namely, atherosclerotic disease, heart failure, and sudden cardiac death. We currently lack models to effectively risk stratify these patients, and we have a poor understanding of the biology underlying their high rates of cardiovascular morbidity and mortality. We intend to apply a novel test, capable of measuring ~5000 proteins in a tiny blood sample, to over 1000 patients with end-stage renal disease on hemodialysis; we aim to discover proteins that would help us pinpoint cardiovascular risk and understand the disturbances in the biology in these patients, with the goal to carry forward novel proteins as potential targets of new treatments for this vulnerable population.

PI_NAMEs: DUBIN, RUTH  (contact);GANZ, PETER

PROGRAM_OFFICER_NAME: PUGGAL, MONA A

PROJECT_TERMS: Address;adjudication;adverse outcome;Age;aptamer;Area;Arrhythmia;Atherosclerosis;beneficiary;Biological;Biological Assay;Biological Markers;Biology;Blood specimen;Cardiac;Cardiovascular Diseases;cardiovascular disorder risk;Cardiovascular Models;cardiovascular risk factor;Cardiovascular system;cerebrovascular;Cessation of life;Chronic Kidney Failure;Chronic Kidney Insufficiency;Clinical;cohort;Complex;Controlled Clinical Trials;Death Rate;Dialysis procedure;disease model;Disease Outcome;Echocardiography;Effectiveness;EFRAC;End stage renal failure;Ethnic Origin;Event;Failure;General Population;Goals;hazard;Heart failure;Hemodialysis;high risk;Hospitalization;hypercholesterolemia;Hypertension;improved;Individual;innovation;insight;Intervention;Left Ventricular Mass;Life Style;Magnetic Resonance;Measures;Medical;Medicare;Methods;Modeling;Morbidity - disease rate;mortality;Myocardial Infarction;new therapeutic target;novel;novel therapeutics;Obesity;Outcome;Participant;Pathway Analysis;Pathway interactions;patient stratification;Patient-Focused Outcomes;Patients;personalized approach;Placebo Control;Plasma;pointed protein;Population;preservation;Prevention approach;prospective;Protein Analysis;protein biomarkers;Proteins;Proteome;Proteomics;Protocols documentation;Public Health;Race;randomized, clinical trials;Regimen;Renal function;Risk;Risk Factors;risk stratification;Sampling;Sensitivity and Specificity;sex;sudden cardiac death;Testing;Therapeutic;therapeutic target;Time;treatment stratification;United States;Visit;Vulnerable Populations

PROJECT_TITLE: Elucidating the Biology of Cardiovascular Risk in Hemodialysis Patients Using Proteomics

STUDY_SECTION: CHSB

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology B Study Section[CHSB]


ADMINISTERING_IC: NS

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_DEPT: NEUROSURGERY

PHR: PROJECT NARRATIVE Mast cells are localized to the brain and meninges in the central nervous system, and are responsible for initiating immunological defense against invading pathogens and detecting brain injury. This proposal seeks to study the role of a mouse mast cell specific receptor, Mrgprb2, in the regulation of neuroinflammation after ischemic stroke. The proposed research will lead to a more comprehensive understanding of mast cell responses after cerebral ischemia, and potentially validate Mrgprb2 as a novel target in the treatment of ischemic stroke.

PI_NAMEs: XU, RISHENG  (contact)

PROGRAM_OFFICER_NAME: REZAIZADEH, KAVON PAUL

PROJECT_TERMS: Address;Agonist;animal imaging;Animal Model;Asthma;Attenuated;Biochemical;Blood;blood-brain barrier disruption;Brain;Brain Injuries;Brain Ischemia;career;CCL2 gene;Cell Death;Cell Degranulation;Central Nervous System;Cerebral Ischemia;cerebrovascular;Cerebrovascular Disorders;Cerebrum;Cessation of life;Charge;Chymase;Clinical;Cocaine Dependence;Connective Tissue;cortistatin;Data;Development;disability-adjusted life years;Effector Cell;Ethics;Exhibits;experience;experimental study;FDA approved;Fellowship;Female;first responder;Fluorescence;G-Protein-Coupled Receptors;Genetic Transcription;glial activation;Goals;Heparin;Hypersensitivity;IgE;immune activation;Immune system;Immunohistochemistry;Immunologic Surveillance;Immunologics;Immunology;improved;In Vitro;in vivo;Individual;Infiltration;Inflammation;inhibitor;Injury;innate immune pathways;Innate Immune System;Intervention;Invaded;Investigation;Ischemic Stroke;K-Series Research Career Programs;Kallidin;Knowledge;Label;Leukocytes;Ligands;Location;Macrophage Activation;male;mast cell;Measures;Mechanics;Mediating;Mediator;medical schools;Meningeal;Meninges;Mentors;Microdissection;Microglia;Middle Cerebral Artery Occlusion;Modeling;Molecular Medicine;monocyte;Morbidity - disease rate;mortality;Mucous Membrane;multidisciplinary;Mus;Myelogenous;Natural Killer Cells;Neuroimmune;neuroinflammation;Neurological outcome;Neuronal Injury;Neurosciences;neurosurgery;neutrophil;Neutrophil Activation;Neutrophil Infiltration;novel;novel strategies;novel therapeutics;Outcome;pathogen;Pathology;Pathway interactions;Patients;Pattern;Peptides;Peripheral;pharmacologic;Pharmacology;Physiological;Play;Population;post stroke;pre-clinical;Prevalence;Production;professor;Proteins;Reaction;receptor;recruit;Regulation;Reporter;Research;response;responsible research conduct;Role;Scientist;screening;sensor;Stains;Stimulus;Stroke;stroke model;Stroke Volume;Substance P;Surface;Surgeon;T-Lymphocyte;Techniques;Testing;Therapeutic;Thermal Hyperalgesias;Thrombectomy;Time;Tissues;Training;Tryptase;Wild Type Mouse

PROJECT_TITLE: Mrgprb2 mediated neuroinflammation after cerebral ischemia

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-1 Study Section[NST-1]


ADMINISTERING_IC: HD

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Pediatric

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

ORG_STATE: PA

PHR: Project Narrative The overall goal of this NRSA-T32 program is to foster the development of pediatric investigators who are prepared to pursue independent academic careers examining important issues relevant to health and disease in children. We accomplish this goal by training outstanding pediatric fellows to become successful physician- scientists, addressing questions of fundamental importance to health and disease in children. Candidates for our program are enrolled in our subspecialty fellowship programs and are identified through national searches for talented pediatricians with signficant potential for success as physician-scientists, with particular emphasis on recruitment of women, underrepresented minorities, individuals with disabilities, and other disadvantaged individuals .

PI_NAMEs: ST. GEME, JOSEPH W. (contact)

PROGRAM_OFFICER_NAME: WINER, KAREN

PROJECT_TERMS: Institution;Pediatric Research

PROJECT_TITLE: T32 Institutional Pediatric Research


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Drug Abuse (NIDA only);Genetics;Neurosciences;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: NEW YORK

ORG_DEPT: NEUROSCIENCES

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: PROJECT NARRATIVE Opiate addiction is a chronic, relapsing disorder that affects millions of individuals worldwide; however, few effective treatment options for opioid abuse and addiction exist. Here, employing a unique combination of behavioral, molecular, epigenomic and viral gene therapy-based approaches, we will assess the impact of chronic heroin self-administration in rats (a well characterized rodent model of volitional opioid use/abuse) on molecular abnormalities in brain – namely aberrant synaptic protein dopaminylation states – that result in heightened propensities for relapse following periods of drug withdrawal. This proposal thus aims to transformatively integrate expertise from multiple disciplines (e.g., molecular neuroscience, epigenomics and behavioral pharmacology) to fully characterize novel synaptic to nuclear signaling cascades contributing to persistent opioid addiction, with the hopes that such information will aid in the future development of more effective therapeutic interventions.

PI_NAMEs: DIETZ, DAVID M;MAZE, IAN S. (contact)

PROGRAM_OFFICER_NAME: SATTERLEE, JOHN S

PROJECT_TERMS: Abstinence;Acute;addiction;Affect;amidation;Amino Acids;Behavior;Behavioral;behavioral pharmacology;behavioral plasticity;Binding;Brain;brain reward regions;Calcium;Calmodulin;calmodulin-dependent protein kinase II;Cell Nucleus;cell type;Cells;Chemicals;ChIP-seq;Chronic;Corpus striatum structure;Coupled;Coupling;CREB1 gene;Cues;Data;Dependence;Deposition;Development;Discipline;Disease;Dopamine;Dopamine D2 Receptor;drug abstinence;Drug Addiction;drug withdrawal;effective intervention;effective therapy;efficacious treatment;Enzymes;epigenomics;Event;Female;Future;gene therapy;genetic manipulation;Genetic Transcription;Glutamine;Goals;Health;Heroin;Histone H3;In Vitro;in vivo;Individual;induced pluripotent stem cell;inducible Cre;Laboratories;Learning;Link;male;Mass Spectrum Analysis;Measures;Mediating;Memory;Molecular;Molecular Abnormality;mutant;neurobiological mechanism;Neurobiology;Neuronal Plasticity;Neurons;Neurophysiology - biologic function;Neurosciences;neurotransmission;novel;Nuclear;Nuclear Translocation;Nucleus Accumbens;Open Reading Frames;Opiate Addiction;Opioid;opioid abuse;opioid use;opioid use disorder;Overdose;Pharmaceutical Preparations;Phenotype;Phosphorylation;Phosphotransferases;Play;Population;Post-Translational Protein Processing;Predisposition;prolonged abstinence;Protein Isoforms;Proteins;Psychological reinforcement;psychostimulant;Public Health;Rat Transgene;Rattus;receptor;Recombinants;Recurrent disease;Regulation;Relapse;relapse prevention;response;Rewards;Rodent Model;Role;Self Administration;Serine;Signal Transduction;Site;Source;Sucrose;Synapses;Synaptic plasticity;Therapeutic Intervention;therapeutically effective;Threonine;transcription factor;transcriptome sequencing;transglutaminase 2;Up-Regulation;Viral;Viral Genes;Virus;Western Blotting

PROJECT_TITLE: Contributions of aberrant synaptic protein monoaminylation to opiate use disorder

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Prevention;Vaccine Related

ORG_CITY: HONOLULU

ORG_NAME: HAWAII BIOTECH, INC.

ORG_STATE: HI

PHR: Project Narrative  The ongoing COVID-19 pandemic has revealed the vulnerability of the human population to yet unknown deadly viruses and the need to be prepared to meet these threats to human health. The ability to quickly development of new vaccines is one way to counter these threats. The proposed project is designed to support this effort by the discovery of new adjuvants which are safe, effective, and easy to manufacture.

PI_NAMEs: JOHNSON, ALAN THOMAS (contact)

PROGRAM_OFFICER_NAME: GAUTAM, RAJEEV

PROJECT_TERMS: 2019-nCoV;Acylation;Adjuvant;Agonist;aluminum sulfate;Attenuated;Biological Assay;Biotechnology;Cells;Cessation of life;combat;Communicable Diseases;cost;COVID-19;COVID-19 pandemic;COVID-19 vaccine;cytokine;design;Development;Disease;Dose;Economics;Event;experience;Face;Future;Goals;Hawaii;Health;Hospitalization;Human;human disease;human pathogen;Immune response;immune stimulatory agent;immunogenic;Individual;Infectious disease threat;influenza outbreak;Innate Immune System;Laboratories;large scale production;Left;Life;manufacture;Messenger RNA;Molecular;Mus;Natural Source;Nature;new chemical entity;novel;novel vaccines;pandemic disease;pandemic preparedness;pathogen;Pathway interactions;Pharmaceutical Chemistry;Pharmaceutical Preparations;Phase;Phospholipids;Play;Population;Positioning Attribute;preclinical study;Preparation;prevent;Production;Property;Protein Subunits;Recording of previous events;Research;Risk;Role;Route;Safety;scaffold;Security;Severities;success;Sucrose;Therapeutic;thermostability;TLR4 gene;tool;Toxic effect;vaccine access;Vaccine Adjuvant;vaccine development;vaccine discovery;Vaccine Research;Vaccines;Virus;West Nile virus

PROJECT_TITLE: Novel TLR-4 Agonists as Vaccine Adjuvants


ED_INST_TYPE: HOSPITALS

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: PROJECT NARRATIVE Somatic mutations in RBM10, encoding a regulator of alternative splicing, frequently co-occur with KRAS in non- small cell lung cancer. This proposal will characterize mechanisms of immune evasion and evaluate novel combination immunotherapy strategies in RBM10-deficient NSCLC.

PI_NAMEs: SKOULIDIS, FERDINANDOS  (contact)

PROGRAM_OFFICER_NAME: SINGH, ANJU

PROJECT_TERMS: Alternative Splicing;Animal Model;anti-PD-L1;AXIN1 protein;Biological Assay;Biological Response Modifiers;C-terminal;Cancer cell line;Cancer Model;Cancer Patient;CD8-Positive T-Lymphocytes;Cell Line;Cell model;Cells;Cessation of life;chemotherapy;Clinical;clinical efficacy;Clinical Trials;clinically significant;Collection;Combination immunotherapy;CSF1 gene;CSF1R gene;Data;Data Set;DNA Damage;DNA Double Strand Break;DNA Repair;DNA Sequence Alteration;Event;Exhibits;Exons;Fostering;Foundations;Genomic Instability;genomic profiling;Genomics;Growth;Homeostasis;Human;Immune;immune checkpoint blockade;Immune checkpoint inhibitor;Immune Evasion;immune resistance;Immunobiology;Immunocompetent;immunoregulation;Immunotherapy;in vivo;ipilimumab;IRF3 gene;KRAS2 gene;Link;loss of function;Lung Adenocarcinoma;Macrophage;Mediating;Mediator;Medicine;Minority;Modeling;Molecular;Monoclonal Antibodies;mouse model;multidisciplinary;Mus;mutant;Mutation;Myeloid Cells;Myeloid-derived suppressor cells;neoplastic cell;Nivolumab;Non-Small-Cell Lung Carcinoma;novel;Oncogenic;Operative Surgical Procedures;Outcome;participant enrollment;Pathway interactions;Patients;Phase;Phase III Clinical Trials;Phenotype;Platinum;Pre-Clinical Model;programmed cell death protein 1;Property;Protein Isoforms;Protein Truncation;Publications;Randomized;recruit;Research Personnel;Resected;response;RNA Splicing;Sampling;Shapes;Signal Pathway;Signal Transduction;Somatic Mutation;Specimen;STAT3 gene;TBK1 gene;Therapeutic;Translations;tumor;Tumor Escape;Tumor Immunity;tumor immunology;tumor microenvironment;Tumor Promotion;tumor-immune system interactions;tumorigenesis;tumorigenic;Work

PROJECT_TITLE: Dissecting and targeting mechanisms of genomic instability-triggered immune evasion in RBM10-deficient non-small cell lung cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-TIO-D(01)Q]


NIH_SPENDING_CATS: Clinical Research;Genetics;Human Genome;Kidney Disease;Orphan Drug;Precision Medicine;Prevention;Rare Diseases;Urologic Diseases

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE Urinary stone disease (USD), is extremely common, affecting up to 12% of individuals in developed countries, is associated with signiﬁcant morbidity including pain, hospitalizations, surgical procedures, and lost work time, and is often recurrent and can lead to progressive chronic kidney disease (CKD). There is strong evidence for a genetic component to both rare and common causes of USD. This proposed project will examine in great detail candidate genes implicated in USD to increase understanding of the underlying pathogenic events, suggest new treatments, and allow assembly of homogeneous cohorts of affected individuals for future study.

PI_NAMEs: HARRIS, PETER C.;LIESKE, JOHN C (contact)

PROJECT_TERMS: Accounting;Affect;Age;biobank;Biochemical;Biology;Calcium;calcium metabolism;Candidate Disease Gene;Chronic Kidney Failure;Clinic;Clinical;clinical trial recruitment;Clinical Trials;Code;cohort;Cohort Studies;Communities;Data;Developed Countries;Diagnosis;Disease;Disease Pathway;disease phenotype;disorder risk;early onset;Etiology;Event;exome;Frequencies;Future;Gene Expression Profile;Genes;Genetic;genetic analysis;genome wide association study;genome-wide;genotyped patients;Health Care Costs;Heritability;Hospitalization;improved;In Vitro;in vitro Assay;Individual;individualized medicine;Kidney Calculi;Kidney Failure;Link;lost work time;Medical Records;Mendelian disorder;Morbidity - disease rate;Nephrocalcinosis;Nephrolithiasis;Nephrology;Operative Surgical Procedures;Pain;Pathogenesis;Pathogenicity;patient registry;Patients;Phenotype;polygenic risk score;Population;Prevalence;Primary Hyperoxaluria;prospective;Publishing;radiological imaging;Recurrence;Risk;Risk Factors;risk prediction;Role;sex;Single Nucleotide Polymorphism;Surveys;System;Testing;Time;treatment trial;Untranslated RNA;Urinary Calculi;Variant;variant detection;variant of unknown significance;Work

PROJECT_TITLE: An individualized medicine approach to urinary stone disease


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Emerging Infectious Diseases;HIV/AIDS;Immunization;Infectious Diseases;Influenza;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_CITY: CORAL GABLES

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: Narrative This study addresses the immune deficiency in virally suppressed HIV infected young and older individuals that can lead to failure of an effective response to influenza vaccination. It also provides insight into the functioning of a specialized peripheral blood CD4 T cell subset (pTfh for peripheral T follicular helper cell) that can be of critical importance in facilitating Ab responses to influenza and other vaccines. Understanding the underlying defects in pTfh and other cells that impair the antibody secretion by B cells in the context of aging and HIV infection may lead to development of scientific strategies to optimize vaccine responses to improve the immune responses in HIV infected elderly population.

PI_NAMEs: PAHWA, SAVITA  (contact);PALLIKKUTH, SURESH

PROGRAM_OFFICER_NAME: TILAHUN, MULUALEM ENYEW

PROJECT_TERMS: Address;Affect;Age;age effect;age related decline;Aging;Antibodies;Antibody Affinity;Antibody Response;Antigens;antiretroviral therapy;Autologous;B-Lymphocytes;Binding;bioinformatics resource;Biological Assay;CD4 Positive T Lymphocytes;Cell Communication;Cell Physiology;Cell secretion;Cells;Characteristics;Classification;Clonal Expansion;co-infection;Coculture Techniques;comorbidity;Coupled;data integration;Data Set;Defect;Development;Diabetic Ketoacidosis;Disease;Dose;Effectiveness;Elderly;Evaluation;Failure;Feasibility Studies;Florida;Flow Cytometry;flu;Functional disorder;General Population;Generations;Ha antigen;Helper-Inducer T-Lymphocyte;HIV;HIV Infections;HIV Seronegativity;HIV/AIDS;Home;human old age (65+);Immune;immune activation;Immune response;Immune system;Immunity;Immunocompetence;immunodeficiency;immunosenescence;Impairment;improved;In Vitro;in vitro testing;in vivo;Incidence;Inflammaging;Inflammation;Inflammatory;inflammatory marker;Influenza;influenza infection;Influenza vaccination;influenza virus vaccine;insight;interest;Interleukin-2;interleukin-21;Intervention;Kinetics;life span;Lymphoid Tissue;Memory B-Lymphocyte;Monoclonal Antibodies;monocyte;Myocardial Infarction;novel;Older Population;Participant;Peripheral;peripheral blood;Persons;Phenotype;Phosphorylation;Plasma Cells;polarized cell;Population;programmed cell death protein 1;Property;Recommendation;recruit;Reporting;Resolution;responders and non-responders;response;Risk;Role;seasonal influenza;Serology;Signal Transduction;single-cell RNA sequencing;Stat5 protein;Stroke;Structure of germinal center of lymph node;success;T-Lymphocyte Subsets;Technology;Testing;TNF gene;TNFSF5 gene;United States;Up-Regulation;Vaccination;vaccine response;vaccine-induced antibodies;Vaccines;Viral;Virus

PROJECT_TITLE: Tfh dysfunction in HIV and Aging

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AARR-M(02)]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Aging;Digestive Diseases;Microbiome

ORG_CITY: ATLANTA

ORG_DEPT: MISCELLANEOUS

ORG_NAME: GEORGIA STATE UNIVERSITY

ORG_STATE: GA

PHR: The proposed study will interrogate interactions between oligoclonal mouse microbiota and intestinal immune system in old mice to understand how aging immune system, and in particular repertoire of CD4 cells, respond to age-related changes in commensal flora. We will also explore the possible rejuvenating effect of administration of Akkermansia muciniphila and derived from the bacteria antigens on the diversity and function of regulatory T cells in old mice. This research is expected to have an important positive impact on our understanding how to help develop better probiotics that can enhance CD4 regulatory cells in frail individuals.

PI_NAMEs: IGNATOWICZ, LESZEK  (contact)

PROGRAM_OFFICER_NAME: FLORES, ROBERTO L

PROJECT_TERMS: Age;age related;age related changes;Aging;Anti-Inflammatory Agents;Antigens;Bacteria;CD4 Positive T Lymphocytes;Cells;Chronic;Collection;commensal microbes;cytokine;Data;design;Disease;dysbiosis;Ecosystem;Elderly;enteric pathogen;Epitopes;Equilibrium;FOXP3 gene;Functional disorder;Genome;Germ-Free;Goals;Grant;gut inflammation;gut microbiota;Health Benefit;Homeostasis;Human;Immune;Immune system;Immunity;Immunization;immunoregulation;immunosenescence;improved;Individual;Inflammation;Interleukin-10;intestinal homeostasis;Intestines;life span;Mediating;Metabolism;Microbe;microbial;microbiome;microbiome therapeutics;microbiota;microorganism antigen;Mucous Membrane;Mus;novel therapeutic intervention;old mice;older patient;pathogen exposure;Patients;Peptides;Play;prevent;Probiotics;Regulatory T-Lymphocyte;Rejuvenation;Research;resident commensals;response;Role;Specificity;Standardization;System;T-Lymphocyte;Testing;Therapeutic;therapy design;tissue injury;TNFRSF11B gene;transcription factor;Transplantation;Work

PROJECT_TITLE: Microbiome and immunosenescence ofÂ  T cells repertoire


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative A fundamental question in systems neuroscience is how populations of neurons encode sensory input and sup- port perceptual decision making. Here we mathematically model the high-dimensional structure of population responses, identify features that are invariant from trial to trial, and link them to behavioral performance in a discrimation task. This work addresses the Brain Initiative mission to deepen our understanding of cortical func- tion to ultimately improve our treatment of disorders of the central nervous system.

PI_NAMEs: RINGACH, DARIO L (contact)

PROGRAM_OFFICER_NAME: DAVID, KAREN KATE

PROJECT_TERMS: Address;area striata;Behavior;Behavioral;BRAIN initiative;Central Nervous System Diseases;Classification;Code;Color;Communities;Data;Data Set;Decision Making;Diameter;discrimination task;extrastriate visual cortex;Eye;Formulation;Goals;High-dimensional Modeling;Image;improved;in vivo;individual response;Inherited;innovation;Knowledge;Link;Locomotion;Maps;mathematical model;Measures;member;Mission;Modeling;Mus;Neurons;Neurosciences;novel;Pattern;Performance;Population;Population Distributions;Positioning Attribute;predictive modeling;Property;Pupil;Research;response;Role;Sensory;sensory discrimination;sensory input;sensory stimulus;Shapes;Statistical Models;Stimulus;Structure;System;Techniques;Testing;Thalamic structure;two-photon;vector;visual discrimination;visual stimulus;Work

PROJECT_TITLE: Population codes and sensory discrimination


NIH_SPENDING_CATS: Asthma;Lung

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: PROJECT NARRATIVE Chronic inflammatory diseases of the lung are a major public health and economic concern worldwide and there is an urgent need for deeper understanding of the cellular and biochemical mechanisms that regulate lung inflammation in order to uncover novel targets to improve therapeutic treatments. An immune population called Group 2 innate lymphoid cells (ILC2s) have been shown to be critical in driving lung inflammation through production of type 2 cytokines; however, the molecular mechanisms controlling their functional capacity remain poorly understood. The focus of this R01 proposal is to investigate the role of mitochondrial morphology dynamics in regulating ILC2 function, metabolic programming, and lung inflammation.

PI_NAMEs: MONTICELLI, LAUREL ANNE (contact)

PROGRAM_OFFICER_NAME: SUBRAMANIAN, HARIHARAN

PROJECT_TERMS: Activities of Daily Living;Adoptive Transfer;Affect;Age;airway inflammation;Allergens;allergic airway inflammation;Asthma;asthmatic;asthmatic patient;Automobile Driving;Biochemical;Bioenergetics;Catabolism;Cell Physiology;Cells;Cellular biology;Cessation of life;Chemicals;Child;chronic inflammatory lung disease;Clinical;conditional knockout;cytokine;Cytokine Signaling;Data;Development;Disease;Economics;Effector Cell;Exposure to;Flow Cytometry;Generations;Glucose;glucose metabolism;glucose uptake;Glycolysis;Human;Imaging Techniques;Immune;Immunobiology;immunoregulation;Impairment;improved;Individual;Inflammation;Inflammatory;inflammatory lung disease;Knockout Mice;Knowledge;Link;liquid chromatography mass spectrometry;live cell imaging;Lung;lung development;Lymphoid Cell;Metabolic;Metabolism;Mitochondria;mitochondrial fitness;mitochondrial membrane;Molecular;Morphology;mouse model;Mus;novel;Nutrient;Papain;Pathologic;Pathway interactions;Peptide Hydrolases;Physicians;Pilot Projects;Population;prevent;Production;Public Health;Pulmonary Inflammation;response;restraint;Role;Scientist;Signal Transduction;Source;Structure of parenchyma of lung;Techniques;Testing;Therapeutic;Tissues;transcriptome sequencing

PROJECT_TITLE: Innate immune regulation of lung inflammation through mitochondrial dynamics

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


NIH_SPENDING_CATS: Bioengineering;Natural Products

ORG_CITY: AUSTIN

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

PHR: Modular polyketide synthases are enzymatic assembly lines that aid in the production of human medicines ranging from antibiotics to anticancer agents. In order to engineer them to help in the development and production of new medicines, more must be learned about how they are organized and how they operate. We are making these discoveries with the help of powerful electron microscopes and model assembly lines produced in our lab.

PI_NAMEs: KEATINGE-CLAY, ADRIAN TRISTAN (contact)

PROGRAM_OFFICER_NAME: BOND, MICHELLE RUEFFER

PROJECT_TITLE: Determining the Architectures and Activities of Polyketide Synthase Modules

STUDY_SECTION: MSFA

STUDY_SECTION_NAME: Macromolecular Structure and Function A Study Section[MSFA]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Prevention;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: PULLMAN

ORG_DEPT: OTHER CLINICAL SCIENCES

ORG_NAME: WASHINGTON STATE UNIVERSITY

ORG_STATE: WA

PHR: PROJECT NARRATIVE Together, tobacco and alcohol kill more than half a million people in the United States every year, making co- addiction to these substances the leading cause of preventable death. We propose a contingency management (CM) paradigm based on point-of-care urine tests that measure ethyl glucuronide. Theoretically framed within the Addiction Neuroclinical Assessment with hypothesized mechanisms in core domains (i.e., incentive salience, negative emotionality and cognitive function), and proceeding from a sound and innovative scientific premise, we will, for the first time, target smoking and alcohol use by implementing an evidence-based behavioral treatment (CM) for alcohol among participants who have initiated the frontline pharmacotherapy (varenicline) for smoking cessation.

PI_NAMEs: MCPHERSON, STERLING M (contact)

PROGRAM_OFFICER_NAME: REYES-GUZMAN, CAROLYN

PROJECT_TERMS: 2 arm randomized control trial;addiction;Address;Aftercare;alcohol abuse therapy;alcohol comorbidity;Alcohol consumption;alcohol measurement;alcohol use disorder;Alcohols;behavior change;Behavior Therapy;Behavioral;behavioral study;Biochemical;biological sex;Cigarette;cigarette smoking;Clinical;clinical trial analysis;clinically relevant;cognitive function;Combined Modality Therapy;Communities;Consumption;contingency management;Control Groups;Cotinine;Counseling;Dangerousness;Drug abuse;Drug usage;editorial;eligible participant;Emotional;emotional functioning;evidence base;Executive Dysfunction;executive function;experience;follow-up;Future;Glucuronides;group intervention;Health;Healthcare;Heavy Drinking;incentive salience;innovation;Intervention;Investigation;Letters;Measures;Mediator;Modality;neurochemistry;Outcome;Participant;Patient Self-Report;Patients;personalized medicine;Persons;Pharmacotherapy;Pilot Projects;point of care;Population;preventable death;primary outcome;Psychiatry;Psychological reinforcement;Public Health;Randomized;recruit;reduced alcohol use;Research;Risk;secondary analysis;secondary outcome;Severities;Smoker;Smoking;smoking cessation;Smoking Cessation Intervention;smoking initiation;sound;Subgroup;synergism;Testing;Time;Tobacco;tobacco smokers;Tobacco use;treatment as usual;treatment duration;treatment group;treatment response;treatment strategy;two-arm trial;United States;Urine;Validation;varenicline

PROJECT_TITLE: An Addictions Neuroclinical Assessment Based Treatment for Smokers with an Alcohol Use Disorder

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Aging;Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_CITY: AMHERST

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

PHR: PROJECT NARRATIVE  This project will extensively test the design and functionality of a novel Liposomal Encapsulation of Polysaccharides (LEPS) vaccine formulation in protecting aged mice subjects against Streptococcus pneumoniae, the leading cause of community-acquired bacterial pneumonia in the elderly. Success will provide key preclinical data in the translational path of this novel preventative approach to address a critical need in better prophylactic options for pneumococcal disease in the elderly.

PI_NAMEs: PFEIFER, BLAINE A. (contact)

PROJECT_TERMS: Address;Age;aged;Antibody Response;Antigens;Bacteremia;Bacterial Infections;Bacterial Pneumonia;Bacterial Proteins;Basic Science;Benign;Biomedical Engineering;capsule;Carrier Proteins;Cell Physiology;Cessation of life;Chemical Engineering;Clinical;co-infection;Collaborations;Communities;Conjugate Vaccines;Coupling;cross immunity;cross reacting material 197;Data;design;Development;Disease;Disease Progression;Economics;Elderly;Encapsulated;Engineering;expectation;Formulation;Gene Expression Profile;global health;Goals;Grant;Health;Hospitalization;Human;human old age (65+);Immune;Immune response;Immunity;Immunization;immunogenic;Immunologics;Immunology;immunosenescence;improved;Individual;Infection;Infectious disease threat;Influenza;Influenza A virus;innovation;Joints;Licensing;liposomal delivery;Liposomes;Lung;Lung infections;Marketing;Measures;Meningitis;Methodology;Microbiology;Mus;Nasopharynx;novel;novel vaccines;old mice;older adult;Organ;Outcome;particle;pathogen;Pathology;Phenotype;Pneumococcal conjugate vaccine;Pneumococcal Infections;Pneumococcal Pneumonia;Pneumococcal vaccine;Pneumonia;pneumonia model;Polysaccharides;Polyvalent pneumococcal vaccine;Population;pre-clinical;Predisposition;Prevention strategy;Prevnar;Printing;Productivity;prophylactic;Prophylactic treatment;Proteins;Publishing;Reporting;Research;Resistance;Risk;Seasons;Secondary to;Serotyping;Severities;standard of care;stem;Streptococcus pneumoniae;success;Surface;Technology;Testing;Time;Translating;translational progress;Treatment Effectiveness;Universities;Vaccination;vaccination outcome;vaccine candidate;Vaccine Design;vaccine formulation;vaccine platform;Vaccines;Virulence;Virus Diseases;Vulnerable Populations;Work

PROJECT_TITLE: Liposomal Encapsulation Vaccine Design for Pneumococcal Disease in Aged Subjects

STUDY_SECTION: VMD

STUDY_SECTION_NAME: Vaccines Against Microbial Diseases Study Section[VMD]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: CHARLESTON

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: Project Narrative This project investigates the ability of two advanced magnetic resonance imaging (MRI) methods to quantify the impact of a drug treatment on the progression of Alzheimer's disease pathology. These methods, referred to as diffusion MRI and resting-state functional MRI, are sensitive to brain tissue microstructure and brain functional connectivity, respectively. The ultimate goal of this project is to establish better tools for supporting studies aimed at finding improved therapies as well as research into the causes of Alzheimer's disease.

PI_NAMEs: FALANGOLA, MARIA F;JENSEN, JENS H (contact)

PROGRAM_OFFICER_NAME: ROVESCALLI, ALESSANDRA C

PROJECT_TERMS: 3xTg-AD mouse;Affect;Age;Age Months;age related changes;Aging;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease therapy;American;Amyloid;Amyloid beta-Protein;Amyloid deposition;Anatomy;Anisotropy;Assessment tool;Behavior;behavior measurement;Behavioral;Biochemical;Biological;Biophysics;blood oxygen level dependent;Brain;brain abnormalities;brain health;Brain region;brain tissue;care costs;Clinical;Data;Death Rate;design;Development;Diffusion;Diffusion Magnetic Resonance Imaging;drug efficacy;effective therapy;Effectiveness;episodic memory impairment;fimbria;Fimbria of hippocampus;Functional Magnetic Resonance Imaging;Funding;Goals;Healthcare;Hippocampus;Histologic;Human;Image;Imaging Device;imaging modality;improved;Intervention;Magnetic Resonance Imaging;Measures;Methods;Microscopic;Modeling;Monitor;Morphology;mouse model;multimodality;Mus;Myelin;Nerve Degeneration;Neurofibrillary Tangles;neurotrophic factor;non-Gaussian model;non-invasive imaging;non-invasive monitor;novel;old mice;Pathology;Patient Care;Pattern;Peptides;peptidomimetics;Pharmaceutical Preparations;Pharmacotherapy;Physiologic pulse;Positron-Emission Tomography;prevent;Research;response;Rest;Senile Plaques;Structural defect;Structure;support tools;tau Proteins;Techniques;Therapeutic;Therapeutic Intervention;Time;tool;Transgenic Organisms;translation to humans;Treatment Efficacy;treatment response;white matter;Work

PROJECT_TITLE: Diffusion and Functional MRI Monitoring of Therapy Response in Alzheimer’s Disease Mouse Model

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


ORG_CITY: Columbus

ORG_DEPT: SURGERY

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE Type 2 diabetes and obesity are increasing rapidly across the U.S. and worldwide. Lipokines, or signaling lipids, released from adipose tissue have recently been identified as molecules that can mediate metabolic effects, but due to their short half-life their therapeutic potential has not been thoroughly explored. The goal of this proposal is to use a new, non-viral gene delivery platform technology with high translational potential, tissue nanotransfection (TNT), and deliver the genes coding for the enzymes that make the bioactive oxylipin, 12,13-diHOME, resulting in a sustained systemic increase of 12,13-diHOME in circulation, reduced adiposity, and improved metabolic health

PI_NAMEs: GALLEGO-PEREZ, DANIEL ;STANFORD, KRISTIN I (contact)

PROGRAM_OFFICER_NAME: HAFT, CAROL R

PROJECT_TERMS: Address;Adipose tissue;Biology;Body mass index;Brown Fat;Cardiac Myocytes;Cells;Circulation;Clinical;clinically relevant;Code;combat;Compensation;Data;design;effectiveness evaluation;Endocrine Glands;Engineering;Enzymes;EPHX1 gene;Exercise;experimental study;extracellular vesicles;fatty acid metabolism;Fatty Acids;Gene Delivery;Genes;Genomics;Glucose;glucose metabolism;Goals;Half-Life;Health;Homeostasis;Human;improved;insulin sensitivity;Linoleic Acids;Lipids;Longevity;Mediating;Metabolic;Metabolic Control;Mus;nanotransfection;Nature;Non-Insulin-Dependent Diabetes Mellitus;non-viral gene delivery;novel;novel therapeutic intervention;novel therapeutics;Obesity;oxidized lipid;Phenotype;Physiological;Physiology;Plasmids;Population;Pre-Clinical Model;prevent;Process;Production;Regulation;response;Rodent;Signal Transduction;Site;Skeletal Muscle;Skin;skin circulation;Source;Structure;Technology;technology platform;Therapeutic;Time;Tissues;translational potential;trend;Triglycerides;Up-Regulation;uptake;Weight Gain;Wild Type Mouse

PROJECT_TITLE: Engineering the release of oxylipins through the skin

STUDY_SECTION: POMD

STUDY_SECTION_NAME: Pathophysiology of Obesity and Metabolic Disease Study Section[POMD]


NIH_SPENDING_CATS: Brain Disorders;Cancer;Genetics;Kidney Disease;Pediatric;Pediatric Cancer;Rare Diseases;Tuberous Sclerosis

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: Narrative: This project is focused on the roles of the transcription factors TFEB and TFE3, which are key regulators of lysosomal biogenesis, on the pathogenesis and therapy of renal disease in tuberous sclerosis complex (TSC). Our central hypothesis, based on novel preliminary data, is that TFEB and TFE3 drive cell proliferation via a lysosome-dependent mechanism in TSC. We anticipate both scientific and clinical impact, since TFEB/TFE3- and/or lysosome-focused therapies could inhibit the progression of renal disease in TSC.

PI_NAMEs: HENSKE, ELIZABETH P (contact)

PROGRAM_OFFICER_NAME: MARIC-BILKAN, CHRISTINE

PROJECT_TERMS: Adult;Affect;Age;Angiomyolipoma;aquaporin-2;autosome;Biogenesis;Cadherins;Cell Nucleus;Cell Proliferation;Cells;Cessation of life;Child;Clinical;clinical translation;Collecting Cell;Complex;constitutive expression;Cyst;Cystic kidney;Cytoplasm;Cytostatics;Data;Disease;Distal;Drug Screening;Duct (organ) structure;Ductal Epithelial Cell;early childhood;Enzymes;Event;Exocytosis;Extracellular Space;Family;FDA approved;FRAP1 gene;Genetic;genetic testing;Genetic Transcription;Germ Lines;Goals;Guanosine Triphosphate Phosphohydrolases;high throughput screening;Histologic;Human;Hyperactivity;improved;In Vitro;in vivo;in vivo evaluation;Infection;inhibitor;insight;Kidney;Kidney Diseases;Kidney Failure;Kidney Neoplasms;Lead;loss of function mutation;Lysosomes;Malignant Epithelial Cell;Measurement;member;Membrane;Morbidity - disease rate;mortality;mouse model;neoplastic cell;novel;novel therapeutics;Nuclear;Oncogenes;Organelles;Pathogenesis;Patients;pharmacologic;Phosphorylation;pre-clinical;Pre-Clinical Model;prevent;Process;Proliferating;protein complex;Renal Angiomyolipoma;Renal Cell Carcinoma;Role;Seizures;Signal Transduction;Site;small molecule;Solid;Source;Subependymal Giant Cell Astrocytoma;Testing;Therapeutic;transcription factor;TSC1 gene;TSC1/2 gene;TSC2 gene;Tuberous Sclerosis;tumor;young adult

PROJECT_TITLE: Role of TFEB and TFE3 in Tuberous Sclerosis Complex (TSC) Kidney Disease

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Cocaine;Eating Disorders;Mental Health;Neurosciences;Nutrition;Obesity;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: NEW HAVEN

ORG_DEPT: PSYCHIATRY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative The prefrontal cortex (PFC), insula, and ventral striatum are prime candidate regions when it comes to understanding the neurobiology of binge eating disorder (BED). However, there is a significant gap when it comes to understanding potential micro-architectural changes (i.e., at the level of synaptic density) that may underpin cortical-insular-striatal abnormalities and related clinical measures. If funded, the proposed study would be the first in vivo examination of synaptic density among unmedicated adults with BED (in comparison to healthy controls), using breakthrough 11C-UCB-J PET methodology to assess synaptic density in the brains of living people.

PI_NAMEs: ANGARITA, GUSTAVO ADOLFO;POTENZA, MARC N (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: Abstinence;Adult;Affect;Age;Anterior;Area;Axon;Behavior assessment;behavior measurement;Behavior Therapy;Behavioral;Binge Eating;Binge eating disorder;Biological Markers;biomarker development;Body mass index;Body Weight decreased;Brain;cingulate cortex;Clinical;clinical translation;clinically relevant;cocaine use;Cocaine use disorder;Cognitive;cognitive function;cognitive system;cognitive testing;Control Groups;Corpus striatum structure;Data;Dendritic Spines;density;Development;Diagnosis;DSM-V;Eating;Eating Disorders;effective intervention;effective therapy;Ethnic Origin;first-in-human;flexibility;Food;Frequencies;Funding;Future;Gender;Glycoproteins;Hospitals;Human;Image;imaging properties;improved;Impulsivity;In Vitro;in vivo;independent component analysis;Individual;Insula of Reil;Intake;interest;International Statistical Classification of Diseases and Related Health Problems, Tenth Revision (ICD-10);Intervention;intervention effect;Label;Lateral;Linear Models;Link;Literature;Measures;Medial;Methodology;Modality;Modeling;Morbidity - disease rate;Nature;Neurobiology;Neurocognitive;neuroimaging;Neuronal Plasticity;Neurons;novel;Obesity;off-label use;Outcome;Outpatients;Participant;patient population;Persons;Pharmaceutical Preparations;pharmacologic;Phentermine;Positive Valence;Positron-Emission Tomography;pre-clinical;preclinical study;Prefrontal Cortex;presynaptic;Primates;Property;Pyramidal Cells;Questionnaires;Race;radiotracer;receptor;Research;Research Domain Criteria;Reversal Learning;Severities;Short-Term Memory;Specificity;Stimulant;Structure;Substance Use Disorder;Symptoms;Synapses;Synaptic plasticity;Synaptophysin;Techniques;Testing;therapy development;Thinness;Time;tool;topiramate;Tracer;translational study;uptake;Ventral Striatum;Vertebral column;Vyvanse;white matter

PROJECT_TITLE: A 11C-UCB-J PET Study of Synaptic Density in Binge Eating Disorder (BED)

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


PHR: SUMMARY Long-lived reservoirs of HIV-infected cells remain a challenge to study because they make up a very small fraction of immune cells, can be located in difficult to sample anatomic sites (e.g., the central nervous system [CNS]), and are generally less well studied in individuals who undergo treatment interruption. We aim at understanding the expansion dynamics, tissue distribution, and rebound predictors of HIV-1 persistence using several unique clinical cohorts and innovative methods to provide critical insight to mechanisms of HIV-1 persistence and strategies for HIV-1 eradication. These results will define high-resolution, multidimensional views of the virus and immune mechanisms that underlie HIV persistence across the stages and tissues of HIV-1 infection. 1

PI_NAMEs: HO, YA-CHI ;LI, JONATHAN  (contact);TSIBRIS, ATHE M.

PROGRAM_OFFICER_NAME: NOVAK, LEIA KAYE

PROJECT_TERMS: Address;Aftercare;Anatomy;Antigens;antiretroviral therapy;Autopsy;Binding;Blood;Blood specimen;Brain;brain cell;Cell Physiology;Cell surface;Cells;Central Nervous System;Cerebrospinal Fluid;Clinical;Clinical Research;Clinical Trials;Clonal Expansion;Clonality;cohort;Competence;Data Analytics;data modeling;Dimensions;Disease remission;Drug or chemical Tissue Distribution;Epigenetic Process;epigenome;Evolution;first-in-human;fitness;Frequencies;Genetic Transcription;HIV;HIV Infections;HIV-1;Immune;immune function;Immune response;Immune system;Individual;Infection;innovation;insight;Integration Host Factors;integration site;Interruption;Maintenance;mathematical model;Methods;Neurobiology;neutralizing antibody;novel;Participant;Peripheral;peripheral blood;Population;pressure;programs;Proliferating;Proteome;Proviruses;Research Personnel;Resolution;response;Role;Sampling;Techniques;Therapeutic Intervention;Tissues;Transcriptional Activation;transcriptome;Viral;viral rebound;Viral reservoir;Viremia;virology;Virus

PROJECT_TITLE: High-Definition Characterization of the Persistence and Perturbation of the HIV Reservoir


NIH_SPENDING_CATS: HIV/AIDS;Infectious Diseases

PHR: NARRATIVE The primary goal of this Core is to administer the resources, both financial and participant samples, needed for the successful completion of the Project and Core research aims. Specifically, this core will provide administrative and budgetary oversight of the Projects and Cores, organize scientific meetings, produce and submit annual progress reports, assist in the speedy execution of institutional review board applications and material transfer agreements; and coordinate the identification, receipt, and storage of participant samples.

PI_NAMEs: LI, JONATHAN  (contact)

PROJECT_TERMS: AIDS clinical trial group;Communication;data exchange;Goals;HIV;Institution;Institutional Review Boards;Leadership;material transfer agreement;meetings;Participant;programs;Progress Reports;Research;Resources;sample collection;Sampling;scientific organization;Services;Speed;Work

PROJECT_TITLE: High-Definition Characterization of the Persistence and Perturbation of the HIV Reservoir: Admin Core


PROJECT_TERMS: advanced analytics;analytical method;Antibody Therapy;antiretroviral therapy;Binding;Bioinformatics;Biological;biomathematics;Biometry;Cells;Central Nervous System;Collaborations;Complex;Consequences of HIV;Data;Data Analyses;Data Analytics;data integration;data modeling;Data Set;design;Disease remission;Doctor of Philosophy;Equilibrium;experience;experimental study;Genome;Goals;high dimensionality;HIV;HIV Infections;Immune response;Immunologics;Immunotherapeutic agent;Individual;Infection;Institution;integration site;Investigation;Maintenance;mathematical model;member;Methodology;Methods;Modeling;multiple omics;Nature;next generation;novel therapeutics;outcome prediction;peripheral blood;Phenotype;Phylogenetic Analysis;Plasma;programs;Proliferating;Property;Provirus Integration;Proviruses;Research;Research Personnel;Research Project Grants;Role;single cell sequencing;Source;synergism;Technical Expertise;Therapeutic;Time;Tissues;Viral;viral rebound;Viremia

PROJECT_TITLE: High-Definition Characterization of the Persistence and Perturbation of the HIV Reservoir: Data Analytics & Modeling Core


PROJECT_TERMS: Address;Aftercare;AIDS clinical trial group;antiretroviral therapy;Atlases;Binding;Biological Assay;Biological Response Modifiers;CD4 Positive T Lymphocytes;Cells;Clinical;Clonal Expansion;Clone Cells;cohort;Communication;cytokine;data exchange;design;Dimensions;Disease remission;empowerment;Environment;experience;Future;Genetic Transcription;genome-wide;Goals;HIV;HIV-1;Individual;Inflammatory;insight;Institution;Institutional Review Boards;integration site;Interruption;Intervention;Leadership;Maps;material transfer agreement;Mediator;meetings;Membrane Proteins;Modeling;multiple omics;novel;novel therapeutics;Participant;Pathway interactions;patient population;permissiveness;Persons;Population;programs;Progress Reports;protein expression;Proviruses;Research;Research Personnel;Resolution;Resources;RNA;sample collection;Sampling;scientific organization;Services;Speed;T cell receptor repertoire sequencing;T-Lymphocyte;Techniques;Technology;Therapeutic Intervention;Transcriptional Activation;transcriptome;Viral;viral rebound;Viremia;Virus;Withholding Treatment;Work

PROJECT_TITLE: High-Definition Characterization of the Persistence and Perturbation of the HIV Reservoir: Project 1


PHR: Narrative This project focuses on a deep characterization of HIV-1 reservoir cell establishment, evolution and persistence in HIV-1-infected humans.

PI_NAMEs: LICHTERFELD, MATHIAS  (contact)

PROJECT_TERMS: Acute;Address;Anatomy;Anti-Retroviral Agents;Astrocytes;Autopsy;Biological Assay;Blood;Blood specimen;Blood Vessels;Body System;brain cell;Brain region;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cells;Central Nervous System;Central Nervous System Agents;Central Nervous System Infections;Cerebrospinal Fluid;Cessation of life;chromosomal location;Clinical;clinical care;Clonality;Cloning;Collaborations;Collection;Colon;Combined Modality Therapy;comparative;Competence;Computer Models;Critical Pathways;Data Analytics;data modeling;Development;Drug resistance;Event;Evolution;experience;fitness;Frequencies;Functional disorder;Future;Genes;Genetic;Genome;Genomics;Goals;HIV;HIV Infections;HIV-1;Human;Human body;ileum;Immune;Immune system;Immunohistochemistry;Immunologics;In Situ Hybridization;In Vitro;Individual;Infection;insight;integration site;Interdisciplinary Study;Interruption;Length;Location;Longitudinal Studies;lymph nodes;Lymphoid Tissue;Macrophage;Maintenance;Maps;Measures;Mediating;Microglia;migration;Minor;Modeling;Myelogenous;Neurocognitive;Neurology;neuropathology;neutralizing antibody;next generation sequencing;novel;Pathogenesis;Pathway interactions;Patients;peripheral blood;Phylogenetic Analysis;Plasma;Population;Predisposition;prevent;Primary Infection;Procedures;Proviruses;repository;Research Personnel;Research Project Grants;Resolution;Role;Sampling;single molecule;Sorting;Spleen;T-Lymphocyte Epitopes;Technology;technology development;therapeutic development;Therapeutic Intervention;Time;Tissues;tool;urogenital tract;vector;Viral;viral rebound;Viral reservoir;Viremia;virology;Virus Diseases;Virus Replication

PROJECT_TITLE: High-Definition Characterization of the Persistence and Perturbation of the HIV Reservoir: Project 2


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Assistive Technology;Autism;Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric

ORG_CITY: LAWRENCE

ORG_NAME: UNIVERSITY OF KANSAS LAWRENCE

ORG_STATE: KS

PHR: PROJECT NARRATIVE This study will use a Sequential Multiple Assignment Randomized Trial (SMART) design to examine and identify alternative combinations of peer-mediated approaches, such as the addition of a speech-generating device, to improve social communication of preschool-age children with ASD and limited or no spoken language. This research is of high relevance to public health for children with ASD and complex communication needs as the focus is on increasing knowledge on how to adapt and tailor peer-mediated social interventions to ensure optimal outcomes for those who do not make anticipated progress. These interventions can be adopted by community-based, early service providers to impact peer-related social competence that is vital to the growth of multiple aspects of child development.

PI_NAMEs: THIEMANN-BOURQUE, KATHY  (contact)

PROGRAM_OFFICER_NAME: COOPER, JUDITH

PROJECT_TERMS: Academic achievement;adaptive intervention;Address;Adopted;Adult;Aftercare;Apple;autism spectrum disorder;autism symptoms;autistic children;Blinded;Child;Child Development;Classification;Clinical Trials;Communication;Communication difficulty;Communities;Complex;Data;Development;disability;Early Intervention;Educational Activities;Educational process of instructing;effective intervention;elementary school;Emotional;Ensure;Environment;flexibility;follow-up;Goals;Growth;improved;improved outcome;innovation;input device;Instruction;Intervention;Joints;kindergarten;Knowledge;Language;Lead;Learning;Learning Disorders;Length;Measures;Mediating;minimally verbal;Modeling;Nodal;non-verbal;novel;Nursery Schools;Outcome;Output;Participant;peer;peer coaching;Phase;Play;Prediction of Response to Therapy;primary outcome;Problem behavior;Public Health;Qualifying;Randomized;reinforcer;Reporting;Research;Research Personnel;response;School-Age Population;Sequential Multiple Assignment Randomized Trial;Series;service providers;Site;skills;social;social communication;social communication impairment;social interventions;social skills;Speech;statistics;teacher;Teaching Method;Testing;Training;treatment response;trial design;verbal;virtual vocal tract;Vocabulary;vocalization;Voice;Work

PROJECT_TITLE: Examining adaptive peer-mediated interventions for preschoolers with autism spectrum disorder and limited or no spoken language: A Sequential Multiple Assignment Randomized Trial

STUDY_SECTION: LCOM

STUDY_SECTION_NAME: Language and Communication Study Section[LCOM]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_DEPT: BIOLOGY

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

PHR: PROJECT NARRATIVE Influenza persists globally, causing nearly one billion cases and hundreds of thousands of deaths annually. While temperate regions of the world experience regular seasonal patterns of influenza with high predictability, tropical regions, many of which are resource-scarce, do not have well-established evidence of regular cycles of influenza epidemics. The proposed research seeks to use mathematical models to determine whether tropical regions experience regular cycles of influenza epidemics or irregular epidemics, using surveillance data from Vietnam as a case study, which can allow tropical nations to understand the predictability, or lack thereof, of influenza.

PI_NAMEs: SERVADIO, JOSEPH  (contact)

PROGRAM_OFFICER_NAME: BOZICK, BROOKE ALLISON

PROJECT_TERMS: Area;Behavior;Biological;Calendar;Case Study;Cessation of life;Characteristics;Circulation;Climate;Clinical;Country;COVID-19 vaccine;cross immunity;Data;design;Disease Outbreaks;Epidemic;Epidemiology;Evaluation;evidence base;Exhibits;experience;flu transmission;Future;Holidays;Human;Immune;Immunity;Incidence;Infection;Influentials;Influenza;Influenza A virus;influenza epidemic;influenza surveillance;Influenza vaccination;influenza virus strain;influenza virus vaccine;influenzavirus;Literature;mathematical model;Modeling;Pattern;Periodicals;Periodicity;Population;Population Heterogeneity;Predisposition;Productivity;Public Health;public health intervention;Recommendation;Recovery;Reporting;Reproduction;Research;Resource-limited setting;Resources;Respiratory Disease;respiratory virus;response;Risk;Running;SARS-CoV-2 infection;Schools;seasonal influenza;Seasonal Variations;Seasons;Series;Structure;surveillance data;System;Testing;Time;transmission process;trend;United States;Update;Vaccination;vaccination strategy;vaccine distribution;Vietnam;Virus;Virus Diseases;Work

PROJECT_TITLE: Evaluating seasonality of influenza in the tropics: Case study in Vietnam

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F18-A(20)]


PI_NAMEs: TSIBRIS, ATHE M. (contact)

PROJECT_TERMS: Affect;AIDS clinical trial group;Animal Model;Antibodies;Antibody Therapy;antibody-dependent cell cytotoxicity;antigen binding;Antigen-Presenting Cells;antiretroviral therapy;Attention;Binding;Binding Sites;Biology;CD8-Positive T-Lymphocytes;Cell Physiology;Cell surface;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Clinical;cohort;cytotoxic CD8 T cells;Dendritic cell activation;design;Detection;Disease remission;DNA;Dose;Enrollment;epigenome;Equilibrium;Evolution;Fab domain;Fc domain;FCGR3B gene;first-in-human;follow-up;Goals;Half-Life;HIV;HIV-1;human study;IgG Receptors;IgG1;Immune;immune function;Immune response;Immune system;immune system function;Immunity;Immunotherapeutic agent;improved;in vivo;Individual;Infection;Infusion procedures;Length;Macaca;Maintenance;Malignant Neoplasms;Mediating;Modification;Monoclonal Antibodies;multimodality;Natural Killer Cells;neonatal Fc receptor;neutralizing antibody;new technology;novel;novel therapeutics;Participant;Patient Compliance;Peripheral;peripheral blood;Phase;Phenotype;Phylogeny;Placebos;Polysaccharides;Population;pressure;Prevention;Process;Production;Proteins;Proteome;Proviruses;receptor expression;Rectum;Regulatory T-Lymphocyte;Residual state;Resolution;response;RNA;Role;Sampling;Serum;simian human immunodeficiency virus;single cell analysis;single cell ATAC-seq;Specificity;T cell response;T-Lymphocyte;Techniques;Testing;Therapeutic Intervention;Therapeutic Monoclonal Antibodies;Time;Tissues;transcriptome;Treatment Protocols;Vaccines;Variant;Viral;Viral Proteins;Viral reservoir;Viremia;Virion;Virus;Work

PROJECT_TITLE: High-Definition Characterization of the Persistence and Perturbation of the HIV Reservoir: Project 3


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Genetic Testing;Genetics;Health Services;Infant Mortality;Machine Learning and Artificial Intelligence;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention

ORG_DEPT: GENETICS

PHR: Project Narrative: We will establish novel genetic and metabolomic technology for newborn screening (NBS) from dried blood spots, and apply machine learning to reduce false-positive screens and delayed diagnosis of true-positive cases. Early detection and confirmation of inborn errors of metabolism that can present in the first weeks of life is critical, specifically when screening in diverse multiethnic populations where we have less understanding of the biochemical genetic and clinical phenotypes. We will work with local hospitals and the NBS program to establish clinical and translational validity to this new project, which will contribute to maintaining parental trust in public NBS.

PI_NAMEs: SCHARFE, CURT  (contact)

PROGRAM_OFFICER_NAME: PARISI, MELISSA

PROJECT_TERMS: Adoption;Affect;Archives;Biochemical;Biochemical Genetics;Biological Assay;Birth;Blood;Blood Volume;California;carrier status;Chemicals;Clinical;clinical phenotype;Compound Q;cost;Cystic Fibrosis Transmembrane Conductance Regulator;Data;Data Analyses;Detection;Diagnosis;Diagnostic;Differentiation Antigens;DNA;DNA sequencing;Dryness;Early Diagnosis;Ethnic Population;Exclusion;Family;Genes;Genetic;genetic analysis;genetic approach;genetic disorder diagnosis;Goals;Haplotypes;Healthcare Systems;Hospitals;improved;Inborn Errors of Metabolism;Infant;Intervention;Laboratories;Letters;Life;Link;Machine Learning;Mass Spectrum Analysis;Measurement;member;Metabolic;Metabolic Diseases;Metabolic Marker;metabolomics;Methods;multi-ethnic;Neonatal Screening;new technology;Newborn Infant;next generation sequencing;novel;novel marker;novel strategies;Outcome;Parents;Patients;Phase;Physicians;Pilot Projects;random forest;Recommendation;Research;Risk;Running;Sampling;screening;screening panel;screening program;Sensitivity and Specificity;Spottings;Symptoms;tandem mass spectrometry;Technology;Testing;Time;Translating;Translations;Trust;Uncertainty;Urine;Variant;web-based tool;Work

PROJECT_TITLE: Multiplex gene sequencing and metabolomics analysis from newborn dried blood spots to improve screening and diagnosis of metabolic disorders.

STUDY_SECTION: TAG

STUDY_SECTION_NAME: Therapeutic Approaches to Genetic Diseases Study Section[TAG]


ORG_CITY: WORCESTER

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: The human microbiome is key for proper development and for maintaining our health. However, many widely administered drugs, that are not prescribed as antibiotics, can inadvertently inhibit the growth of some of its bacterial members. We will identify what are the processes inside bacterial cells that are targeted by these drugs, and we will find the mutations that may help bacteria resist this inhibition that is detrimental to our health.

PI_NAMEs: MITCHELL, AMIR  (contact)

PROGRAM_OFFICER_NAME: XU, ZUOYU

PROJECT_TERMS: Antibiotic Resistance;Antibiotic Therapy;Antibiotics;antimicrobial;Bacteria;Biological Models;Categories;Cells;Chronic;Classification;Complement;computerized tools;Consumption;Development;drug mechanism;Drug Modelings;Drug Prescriptions;Drug resistance;Drug Screening;drug sensitivity;Drug Targeting;dysbiosis;Escherichia coli;Evolution;experimental study;Future;gain of function;gain of function mutation;Genetic Screening;Genome;Goals;Graph;Growth;gut microbiome;Health;Human Development;Human Microbiome;Intervention;Knock-out;knockout gene;loss of function;Maintenance;Maps;mathematical model;Measurement;Measures;member;microbial;microbiome;Multi-Drug Resistance;Mutation;Pathway interactions;Pharmaceutical Preparations;Physiological;Post-Translational Protein Processing;pressure;Probability;Process;Resistance;resistance mechanism;Resistance profile;resistant strain;Risk;screening;Testing;Time;Toxic effect;Work;Xenobiotics

PROJECT_TITLE: Mechanisms underlying bacterial sensitivity to host-targeted drugs

STUDY_SECTION: DDR

STUDY_SECTION_NAME: Drug Discovery and Mechanisms of Antimicrobial Resistance Study Section[DDR]


NIH_SPENDING_CATS: Cancer;Genetics;Orphan Drug;Ovarian Cancer;Rare Diseases;Women's Health Research

ORG_CITY: PITTSBURGH

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative The oncogene cyclin E is amplified/overexpressed in ~20% of high grade serous ovarian cancers, but no current treatment strategies exist to target this patient population. In this study, we will quantitatively assess acetyl-CoA metabolism and subsequent histone hyperacetylation that enhances homologous recombination-mediated DNA repair and evaluate inhibition of this axis with emerging standard-of-care PARP inhibitor treatment. The results will have a direct impact on the development of novel therapeutic strategies to obtain a therapeutic response in high grade serous ovarian cancer patients with high cyclin E expression.

PI_NAMEs: AIRD, KATHERINE MARIE (contact);SNYDER, NATHANIEL W.

PROGRAM_OFFICER_NAME: WEINREICH, MICHAEL DALE

PROJECT_TERMS: Acetyl Coenzyme A;Acetylation;Address;Affect;ATP Citrate (pro-S)-Lyase;cancer cell;Cancer Patient;cancer type;CCNE1 gene;Cell Cycle Progression;Cell Nucleus;Cells;Chromatin;Clinical;clinically relevant;Cytoplasm;Data;Dependence;Development;Disease;DNA Damage;DNA Repair;DNA Repair Enzymes;Enzymes;Epigenetic Process;epigenome;Event;Future;Genetic Transcription;Glucose;Goals;Histone Acetylation;histone acetyltransferase;Histones;homologous recombination;homologous recombination deficiency;Human;improved;inhibitor;inhibitor therapy;insight;Knowledge;Link;Malignant neoplasm of ovary;Malignant Neoplasms;Mammalian Oviducts;Mediating;Metabolic;Metabolism;Modeling;Molecular;new therapeutic target;novel strategies;novel therapeutic intervention;Oncogenes;Oncogenic;Ovarian;overexpression;Pathway interactions;patient population;Patients;Pharmaceutical Preparations;Phenotype;Poly(ADP-ribose) Polymerase Inhibitor;programs;Proliferating;Proteins;Publishing;recombinational repair;recruit;Relaxation;replication stress;Research;Resistance;response;Role;Serous;spatiotemporal;standard of care;synergism;Testing;Therapeutic;therapy outcome;treatment response;treatment strategy;tumor;tumorigenesis;tumorigenic

PROJECT_TITLE: Metabolic and epigenetic reprogramming in cyclin E high ovarian cancer

STUDY_SECTION: TCB

STUDY_SECTION_NAME: Tumor Cell Biology Study Section[TCB]


ORG_CITY: NEW ORLEANS

ORG_DEPT: PHYSIOLOGY

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: PROJECT NARRATIVE  The present proposal targets unique mechanisms that contribute to the molecular and genetic and epigenetic basis of high blood pressure (BP) and kidney injury and dysfunction. It is anticipated that men and women can have distinct differences in progression of hypertensive kidney diseases; the proposed studies will utilize genetically modified mouse models to provide new insights in developing the therapeutic strategies to appropriately target the treatment and prevention of high BP and kidney injury and disorders. The podocyte and nephron tubule injury and kidney dysfunction can lead to chronic kidney disease and complications that are directly relevant to the mission of NIH/NIDDK.

PI_NAMEs: PANDEY, KAILASH N (contact)

PROJECT_TERMS: Abnormal Cell;Adult;Age;Agonist;Angiotensin II;Atrial Natriuretic Factor;atrial natriuretic factor receptor A;Atrial Natriuretic Factor Receptors;blood pressure regulation;Brain natriuretic peptide;Cardiovascular Diseases;cell determination;cell type;Cells;Cessation of life;chromatin modification;Chronic Kidney Failure;Cyclic GMP;decubitus ulcer;Diagnosis;Disease;Epigenetic Process;Etiology;Exhibits;expectation;Female;Functional disorder;Gender;Gene Expression;Gene Expression Regulation;Gene Modified;Genes;Genetic;Genetic Polymorphism;Genetic Transcription;Goals;Haplotypes;Heart failure;Histone Code;Histones;Hormonal;Hormones;Human;Hypertension;improved;in vivo;Injury;Injury to Kidney;insight;Kidney;kidney cell;Kidney Diseases;kidney dysfunction;knockout gene;Lead;male;men;Mission;Molecular;molecular marker;Molecular Target;mouse model;Mus;Mutant Strains Mice;National Institute of Diabetes and Digestive and Kidney Diseases;Nephrons;new therapeutic target;novel;novel marker;Organ;Pathogenesis;Phenotype;Play;podocyte;prevent;Prevention;Publishing;receptor expression;receptor function;Receptor Signaling;recruit;renal damage;Renal Hypertension;Repression;Research;retinoic acid receptor alpha;Role;Second Messenger Systems;sex;Sex Differences;Signal Transduction;Testing;TGFB1 gene;Therapeutic;tool;transcription factor;United States National Institutes of Health;Woman

PROJECT_TITLE: ANP Receptor: Genetic and Epigenetic Mechanisms Regulating Blood Pressure and Kidney Injury and Dysfunction


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_CITY: NEW YORK

ORG_DEPT: ORTHOPEDICS

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: NARRATIVE The 2023-2025 Summer Biomechanics, Bioengineering, and Biotransport Conferences provide opportunities to share current bioengineering research. We ask for NIH support to support our goal increasing the participation of trainees from groups traditionally underrepresented in bioengineering.

PI_NAMEs: THOMOPOULOS, STAVROS  (contact)

PROGRAM_OFFICER_NAME: GUTEKUNST, DAVID JOSEPH

PROJECT_TERMS: Area;Award;Biomechanics;Biomedical Engineering;broadening participation research;career;Cells;Child Care;Collaborations;Communities;community college;design;Development;Disabled Persons;Discipline;Doctor of Philosophy;Education;Educational workshop;Ensure;Event;experience;Faculty;Fees;Female;Financial Support;Funding;Goals;graduate school;Grant;Historically Black Colleges and Universities;Hour;Industry;innovation;Institution;interest;International;Leadership;lectures;Liquid substance;Mechanics;meetings;Mentors;Mentorship;Mission;novel;Oral;Paper;Participant;peer;Persons;posters;programs;Rehabilitation therapy;Research;Research Personnel;Research Technics;Resort;Scientific Societies;Social Interaction;Solid;student participation;Students;symposium;Tissue Engineering;Tissues;Travel;undergraduate student;Underrepresented Populations;Underrepresented Students;United States National Institutes of Health;virtual;Woman


NIH_SPENDING_CATS: Aging;Atherosclerosis;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Nutrition;Prevention

PHR: Project Narrative Atherosclerotic cardiovascular diseases remain the leading causes of death in the United States. The high saturated fat, cholesterol, and refined carbohydrate intakes associated with a Western-type diet is considered a major cause of atherosclerosis. However, we discovered that high protein intake could also be involved in the adverse vascular health effects of a Western-type diet. In this proposal, we will discern the mechanism of how dietary protein impacts immune cells that are involved in forming atherosclerotic plaques. This work has important public health implications, because it may lead to new dietary guidelines. Currently, high protein intake is considered healthy and has become popular. Our work also has the potential to uncover new avenues for therapeutic intervention.

PI_NAMEs: MITTENDORFER, BETTINA ;RAZANI, BABAK  (contact)

PROGRAM_OFFICER_NAME: FLEG, JEROME L

PROJECT_TERMS: Address;Adult;Adverse effects;Affect;Amino Acids;Animal Model;Animal Sources;Animals;Arterial Fatty Streak;atherogenesis;Atherosclerosis;Biological Assay;Blood specimen;Blood Vessels;burden of illness;cancer clinical trial;cancer therapy;Carbohydrates;Cardiovascular Diseases;cardiovascular disorder risk;Cardiovascular system;Cause of Death;Cell Culture System;Cells;Characteristics;Cholesterol;Clinical;Consumption;cytotoxic;Data;Diet;dietary;dietary guidelines;Dietary Proteins;Dose;Dyslipidemias;Evaluation;FRAP1 gene;Genetically Engineered Mouse;Goals;Health;Human;Immune;Impairment;In Vitro;in vivo;Ingestion;inhibitor;insight;Intake;Knockout Mice;Lesion by Morphology;Leucine;Liquid substance;Macrophage;Marketing;Mediating;men;Mitochondria;monocyte;Morbidity - disease rate;mortality;mouse model;Mus;Myocardial Infarction;Necrosis;novel;Obesity;Pathogenesis;Pathway interactions;Persons;pharmacologic;Plant Proteins;Plant Sources;Plasma;Population;Populations at Risk;prevent;Proliferating;protein aggregation;protein intake;Proteins;Public Health;Recommendation;response;Risk;Risk Factors;Rupture;saturated fat;Signal Transduction;Societies;Stroke;Testing;Therapeutic;Therapeutic Intervention;Thinness;Translating;United States;uptake;Vascular Plant;western diet;Woman;Work

PROJECT_TITLE: Dissecting the Impact of Dietary Protein on Macrophage mTOR Signaling and Atherosclerosis

STUDY_SECTION: AVI

STUDY_SECTION_NAME: Atherosclerosis and Vascular Inflammation Study Section[AVI]


ORG_CITY: DALLAS

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: PROJECT NARRATIVE Cell-cell fusion is fundamental to the conception, development and physiology of multicellular organisms. It is involved in processes as diverse as fertilization, myogenesis, bone remodeling, placental development, immune response and tumor metastasis. Thus understanding the mechanisms of cell-cell fusion is not only important for fundamental biology, but may also provide basis for its manipulation in therapeutic settings for human diseases.

PI_NAMEs: CHEN, ELIZABETH H (contact)

PROGRAM_OFFICER_NAME: MACARTHUR, LINDA

PROJECT_TERMS: Actins;Albers-Schonberg disease;Biochemistry;Biological Process;Biology;Biophysics;Bone remodeling;Cell fusion;Cell Line;Cell membrane;Cells;Cellular biology;Conceptions;congenital myopathy;Cytoskeleton;Defect;Development;Developmental Biology;driving force;Drosophila genus;Electron Microscopy;Failure;Fertilization;Genetic;human disease;Image;Immune response;immunodeficiency;in vivo;Infertility;insight;Integral Membrane Protein;interdisciplinary approach;Invaded;Learning;Mammalian Cell;Mammals;Mechanics;Mediating;Membrane;Membrane Biology;Modeling;Molecular Biology;Mus;Myoblasts;myogenesis;Neoplasm Metastasis;novel;Organism;Physiology;Placentation;Pre-Eclampsia;Process;Proteins;reconstitution;Research;response;stem cells;superresolution microscopy;System;Therapeutic;tissue regeneration;tumor;tumorigenesis

PROJECT_TITLE: Decoding the mechanisms of cell-cell fusion

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-Y(55)R]


NIH_SPENDING_CATS: Biotechnology;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hepatitis;Hepatitis - C;Immunization;Infectious Diseases;Liver Disease;Prevention;Vaccine Related

ORG_CITY: SAINT LOUIS

ORG_NAME: SAINT LOUIS UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative Hepatitis C virus (HCV) infection causes silent liver disease and is a major health problem worldwide. A comprehensive strategy to control HCV infection must include an effective vaccine development approach. We will study and select vaccine antigens, use novel vaccine delivery platform, and optimize immunization regimen to induce robust protective immune response against HCV infection.

PI_NAMEs: RAY, RANJIT  (contact)

PROGRAM_OFFICER_NAME: DOO, EDWARD

PROJECT_TERMS: Active immunity;Adjuvant;anti-hepatitis C;Antigen-Presenting Cells;Antigens;B-Lymphocytes;Binding Sites;booster vaccine;CD4 Positive T Lymphocytes;CD81 gene;Cell Culture Techniques;Cell Physiology;Cells;Chronic Hepatitis C;comparative;cost effective;Country;cross reactivity;Development;Encapsulated;end stage liver disease;Environment;Evaluation;experimental study;Generations;Genomic Segment;Genotype;global health;Glycoproteins;Health;Health Benefit;healthy volunteer;Helper-Inducer T-Lymphocyte;Hepatitis C;Hepatitis C Incidence;Hepatitis C Vaccine;Hepatitis C Viremia;Hepatitis C virus;Human;Immune;immune function;Immune response;Immunization;Immunize;Immunocompetent;immunogenicity;immunoregulation;Impairment;improved;Infection;Interruption;lipid nanoparticle;Literature;Liver diseases;low socioeconomic status;Macrophage;Macrophage Activation;Messenger RNA;MF59;mouse model;mRNA lipid nano particle vaccine;Mus;mutant;Mutate;nanoparticle;Natural Killer Cells;Nature;neutralizing antibody;novel vaccines;Nucleosides;pathogen;Patients;Peptides;Peripheral Blood Mononuclear Cell;Pharmaceutical Preparations;Phase;Phenotype;Point Mutation;Populations at Risk;preclinical study;Preventive vaccine;progression risk;protective efficacy;Proteins;Public Health;rational design;Recombinants;Regimen;Research;Resistance;Resource-limited setting;response;Risk;Role;Safety;stem;T cell response;T-Lymphocyte;T-Lymphocyte Epitopes;Testing;transmission process;Vaccinated;Vaccine Adjuvant;Vaccine Antigen;vaccine candidate;vaccine delivery;vaccine development;vaccine efficacy;vaccine evaluation;vaccine platform;vaccine strategy;Vaccines;Vaccinia virus;Viral;Viral Antigens;Viral Proteins;viral RNA;Virus Diseases;virus envelope;volunteer;Work

PROJECT_TITLE: SELECTION OF VACCINE ANTIGENS FOR PROTECTION FROM HEPATITIS C VIRUS INFECTION


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Precision Medicine;Rare Diseases

ORG_DEPT: NEUROLOGY

PHR: Project Narrative: The functional interpretation of genetic variation in diseases faces critical roadblocks, due to the lack of scalable methods to assess the significance of candidate variants experimentally, while accounting for genomic context. This proposal introduces a morphological profiling method, that is able to rapidly identify disease-associated phenotypes in patient cells and offers a cost-efficient and unbiased way to determine the significance of putative pathogenic variants at scale. If successful, this proposal will establish cellular profiling of patient cells as a powerful platform to advance genomic and translational medicine.

PI_NAMEs: PERNICE, WOLFGANG MAXIMILIAN ANTON (contact)

PROGRAM_OFFICER_NAME: GILCHRIST, DANIEL A

PROJECT_TERMS: Address;Award;Benign;Biological;career;Cells;Cellular biology;cellular imaging;Cellular Morphology;Classification;Clinical;cohort;Complement;Complex;computer scientist;cost efficient;Data;Data Science;Data Sources;deep learning;deep learning algorithm;design;Development;Development Plans;Diagnostic;Disease;efficacy testing;Environment;experimental study;Face;Fibroblasts;Fostering;Gene Expression Profiling;gene therapy;Genes;Genetic;genetic association;Genetic Diseases;Genetic Variation;Genome;genome wide association study;genome-wide;Genomic medicine;genomic platform;Genomics;Goals;Hand;hereditary neuropathy;Heritability;Image;individual patient;Intervention;Lead;Leadership;Machine Learning;Malignant Neoplasms;Maps;Measures;Medical Genetics;Methods;microscopic imaging;Mitochondrial Diseases;Molecular;Morphology;multidisciplinary;Nature;Nerve Degeneration;Outcome;Pathogenicity;Patient imaging;patient subsets;patient variability;Patients;personalized genomic medicine;pharmacologic;Phenocopy;Phenotype;Privatization;programs;Protocols documentation;Rare Diseases;Research;Research Personnel;Resolution;Sample Size;Signal Transduction;single-cell RNA sequencing;skills;small molecule libraries;Standardization;statistics;success;Techniques;Technology;technology platform;Testing;Therapeutic Intervention;Time;tool;Training;transcriptome sequencing;translational medicine;Universities;Validation;Variant

PROJECT_TITLE: Integrated morphological and transcriptomic single-cell profiling of patient-derived cells as a platform for genomic and translational medicine

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Genetics

ORG_CITY: RIVERSIDE

ORG_NAME: UNIVERSITY OF CALIFORNIA RIVERSIDE

PHR: PROJECT NARRATIVE  Mammalian DNA methyltransferases are essential for establishing and maintaining DNA methylation patterns during development. Aberrant DNA methylation patterns are associated with numerous human diseases, including cancer and neurological disorders. This proposal will lead to a better understanding of the regulatory mechanisms of mammalian DNA methylation and epigenetics, and ultimately benefit the development of new strategies for the therapeutic intervention of many human diseases.

PI_NAMEs: SONG, JIKUI  (contact)

PROGRAM_OFFICER_NAME: CHOW, CHI-WING

PROJECT_TERMS: Aberrant DNA Methylation;Address;Biochemistry;Cellular biology;Chromatin;Chromatin Remodeling Factor;Chromosomal Instability;Development;DNA Maintenance;DNA Methylation;DNA Methylation Regulation;DNA Modification Methylases;DNA-Protein Interaction;DNMT3a;DNMT3B gene;Embryonic Development;Environment;Epigenetic Process;Gametogenesis;Gene Expression Regulation;Gene Silencing;Genomic Imprinting;Genomic Instability;Goals;histone modification;human disease;insight;interest;intermolecular interaction;Lead;Maintenance;Malignant Neoplasms;Mammals;Mediating;methylation pattern;Mitotic;Molecular;Molecular Biology;Nervous System Disorder;novel therapeutic intervention;Pathway interactions;programs;Protein Engineering;Proteins;Research;Retrotransposon;Specificity;structural biology;Structure;Substrate Specificity;Therapeutic Intervention;Tumor Suppressor Genes;Work;X Inactivation

PROJECT_TITLE: Mechanistic Insights into Mammalian DNA Methylation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-K(55)R]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Brain Disorders;Clinical Research;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Neurosciences;Orphan Drug;Pediatric;Pediatric - AIDS;Rare Diseases;Tuberculosis

ORG_CITY: NIJMEGEN

ORG_COUNTRY: NETHERLANDS

ORG_FIPS: NL

ORG_NAME: STICHTING RADBOUD UNIVERSITAIR MEDISCH CENTRUM I.O.

PHR: Project Narrative Tuberculous meningitis (TBM) is the most lethal manifestation of TB, is associated with permanent neurological disability among many survivors, and is now one of the commonest causes of meningitis worldwide. Considering that TB drug concentrations are the key intermediary link between administered doses and disease outcome, HARVEST-PK provides a unique opportunity to improve understanding of achieved drug exposures, key predictors of exposure, and optimal target concentrations in TBM. This project aims to enable better medical care for persons with meningitis, by enabling exposure optimized drug therapy.

PI_NAMEs: TE BRAKE, LINDSEY  (contact)

PROGRAM_OFFICER_NAME: MAHON III, ROBERT N

PROJECT_TERMS: ABCB1 gene;Address;Adult;Adverse effects;Affect;Africa;African;anti-microbial drug;Anti-Retroviral Agents;antiretroviral therapy;appropriate dose;Asia;Binding Proteins;Biological Markers;Blood;Body Size;Brain Injuries;Caring;Cause of Death;Central Nervous System;Central Nervous System Agents;Cerebrospinal Fluid;Cerebrospinal Fluid Proteins;Characteristics;Child;Clinical Research;Communicable Diseases;Critical Illness;Data;disability;Disease Outcome;Dose;drug distribution;Drug Exposure;Drug Kinetics;Drug Targeting;Drug Transport;Encephalitis;Ethambutol;Evaluation;Exposure to;Extravasation;Genotype;Glasgow Coma Scale;Glial Fibrillary Acidic Protein;Harvest;HIV;HIV/TB;improved;improved outcome;Indonesia;Inflammatory;inflammatory marker;insight;inter-individual variation;interest;International;isoniazid;Knowledge;Link;liver metabolism;Measures;Medical;member;Meningeal Tuberculosis;Meningitis;mental state;Modeling;models and simulation;mortality;mortality risk;Neurocognitive;Neurological disability;Neuron-Specific Enolase;Oral;Outcome;participant enrollment;patient subsets;Patients;pediatric patients;Persons;Pharmaceutical Preparations;Pharmacodynamics;pharmacologic;Pharmacotherapy;Phase;phase III trial;Plasma;Pyrazinamide;Recommendation;response;Rifampin;Risk-Benefit Assessment;Safety;Sampling;Severity of illness;sex;South Africa;southeast Asian;Survivors;Techniques;Testing;treatment guidelines;Treatment outcome;Tuberculosis;tuberculosis drugs;Uganda;Ventricular

PROJECT_TITLE: High Dose Oral Rifampicin to Improve Survival from Adult Tuberculous Meningitis: a pharmacokinetic substudy (HARVEST-PK)

STUDY_SECTION: HCAC

STUDY_SECTION_NAME: HIV Coinfections and HIV Associated Cancers Study Section[HCAC]


NIH_SPENDING_CATS: Adolescent Sexual Activity;Alcoholism, Alcohol Use and Health;American Indian or Alaska Native;Behavioral and Social Science;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Machine Learning and Artificial Intelligence;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Sexually Transmitted Infections;Social Determinants of Health;Substance Misuse;Underage Drinking

ORG_CITY: FARMINGTON

ORG_NAME: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT

PHR: PROJECT NARRATIVE For this proposal, we engage experts in clinical (MPI Feldstein Ewing) and quantitative (Co-I Bryan) evaluations of HIV/STI and syndemic risk reduction with youth, advanced longitudinal models of youth alcohol and cannabis use and their intersection with HIV/STI risk (MPI: Chung), and longitudinal mixed-effects machine learning and patient-provider relationships (Co-I Yang, Consultant Choudhary). Together, we aim to collaboratively harmonize our 6 sizable HIV/STI and syndemic behavioral intervention studies to interrogate these data using cutting-edge analytic methods and robust machine learning model testing. This innovative approach will unearth crucial relations in youth HIV/STI and syndemic intervention response, in a diverse sample of youth at very high risk for HIV (M = 17 years of age, range 13-24 at baseline; 43% female; 21% SGM; 54% Hispanic; 9% African American; 7% Native American/Alaska Native). These data are crucial to informing next step HIV/STI and syndemic intervention programming, as they will illuminate what works (and does not) in this age group.

PI_NAMEs: CHUNG, TAMMY ;FELDSTEIN EWING, SARAH W. (contact)

PROGRAM_OFFICER_NAME: MONGODIN, EMMANUEL FRANCK

PROJECT_TERMS: 17 year old;Address;Adolescent;Adult;Advocate;Affect;African American;Age;age group;Alaska Native;Alcohol consumption;Alcohols;analytical method;arm;barrier to care;Behavior;behavior change;Behavior Therapy;Behavioral;Cannabis;Caring;Clinical;comorbidity;Data;Development;Disparate;Education;Enrollment;Ethnic Origin;Evaluation;Female;follow-up;Funding;Gender;gender minority youth;Goals;Health;high risk;Hispanic;HIV;HIV/STD;improved;Individual;innovation;Intervention;intervention delivery;intervention effect;Intervention Studies;Literature;Machine Learning;machine learning model;marijuana use;Measures;Mindfulness Training;Modality;Modeling;Motivation;motivational enhancement therapy;Native Americans;Nature;Outcome;Participant;Pathway interactions;Patients;Pattern;peer;people of color;Perception;Population Group;post intervention;predictive modeling;Prevention;preventive intervention;primary outcome;Provider;provider factors;Race;Randomized, Controlled Trials;Readiness;Research;response;retention rate;Rewards;Risk;Risk Behaviors;Risk Reduction;Role;Sampling;Self Efficacy;Sexual and Gender Minorities;sexual minority youth;Sexual Partners;skills training;STI prevention;syndemic;Testing;Therapeutic;underage drinking;United States National Institutes of Health;Unsafe Sex;Vulnerable Populations;Work;Youth

PROJECT_TITLE: Linkages between HIV/STI prevention and syndemic behaviors in high risk youth: Common factors and unique pathways

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]