PHR: Project Narrative Extracellular Vesicles (EVs) are shed by all cells in the body into the blood, and so provide a unique opportunity for monitoring the pancreatic islet microenvironment with liquid biopsies. Here we propose to integrate an innovative tool set of bulk and single EV omics, nanotechnologies, and microtechnologies to extract the blood fingerprints of Type 1 Diabetes (T1D) and to develop EV based biomarkers for the early detection of T1D. The proposed methodology, as well as data set, will be of high value to the fundamental and clinical T1D communities.

PI_NAMEs: NG, ALPHONSUS  (contact)

PROGRAM_OFFICER_NAME: BLONDEL, OLIVIER

PROJECT_TERMS: analytical method;Antigens;assay development;Attenuated;Autoantibodies;Autoantigens;Autoimmune;autoreactive T cell;Back;Bar Codes;Beta Cell;Biological Markers;Biology;biomarker identification;Blood;Blood Cells;Body Fluids;candidate marker;CD8-Positive T-Lymphocytes;Cell Communication;Cell Culture Techniques;Cell Line;cell type;Cells;Characteristics;Circulation;Clinic;Clinical;cohort;Collaborations;Communities;Computational Biology;Couples;Cultured Cells;cytotoxic CD8 T cells;cytotoxicity;Data;Data Set;Databases;design;Development;diabetes pathogenesis;Diagnostic;Diameter;digital;Disease;disease diagnostic;Disease Progression;ds-DNA;early detection biomarkers;Early Diagnosis;Event;extracellular vesicles;Fingerprint;Genetic;Goals;Health;Heterogeneity;Human;Hyperglycemia;Image;Immune;Immunology;immunoregulation;Immunotherapy;Individual;Infiltration;innovation;insight;Insulin-Dependent Diabetes Mellitus;islet;Islet Cell;Islets of Langerhans;Knowledge acquisition;Learning;Libraries;Light;Lipids;liquid biopsy;Measures;Mediating;Membrane;Messenger RNA;Methodology;Methods;Microfluidics;MicroRNAs;Molecular;molecular marker;Molecular Profiling;Monitor;multidisciplinary;multiple omics;nanoparticle;nanoscale;Nanotechnology;Nucleic Acids;Organ;Pancreas;Pancreatic Diseases;Pathologic;Patients;Performance;Play;Population;programs;Proliferating;Proteins;Proteome;Proteomics;Public Domains;Reporting;Research Institute;Research Personnel;Resolution;Risk;RNA;Role;Sampling;Scientist;Serum;Set protein;Site;Somatotype;Source;Specimen;Stream;Structure of beta Cell of islet;Systems Biology;T cell infiltration;T-Cell Activation;T-Cell Receptor;T-Lymphocyte;Technology;Testing;Time;Tissues;tool;trafficking;Transcript;transcriptome;transcriptomics;Universities;Utah;Vesicle;Work

PROJECT_TITLE: Micro-nanotechnologies for the analysis of islet-derived extracellular vesicles implicated in Type 1 Diabetes


ADMINISTERING_IC: HD

ARRA_FUNDED: N

ED_INST_TYPE: UNIVERSITY-WIDE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Services;Maternal Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Women's Health Research

ORG_CITY: PHILADELPHIA

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: THOMAS JEFFERSON UNIVERSITY

ORG_STATE: PA

PHR: PROJECT NARRATIVE The Thomas Jefferson University - Jawaharlal Nehru Medical College (Belagavi, India) Women's and Children's Health Research Unit collaboration represents a most productive academic partnership for the conduct of clinical research; for educating students, fellows, and junior faculty; and in fostering enhanced research capacity building. We are poised to utilize new technologies, shared datasets, artificial intelligence, biobanking, microbiome assessments, placental histopathology, and new surveillance techniques to address global challenges, with India often having the highest prevalence of adverse maternal, neonatal, and infant outcomes.

PI_NAMEs: DERMAN, RICHARD J (contact)

PROGRAM_OFFICER_NAME: CHAKHTOURA, NAHIDA ABDO

PROJECT_TERMS: Academic Medical Centers;Accreditation;Achievement;Address;adverse outcome;Anemia;antimicrobial;Area;Artificial Intelligence;biobank;Catchment Area;Cessation of life;Child;Child Health;Child Mortality;Clinical Research;clinical research site;Clinical Trials;Collaborations;Committee Membership;Communicable Diseases;Communication;Communities;community engagement;Community Medicine;Community Networks;cost effective;Country;Data;data access;Data Set;data sharing;design;Development;disability;Discipline of obstetrics;Ensure;Epidemiology;Evidence based intervention;experience;Faculty;Family;fetal medicine;follow-up;Fostering;Funding Opportunities;Future;Goals;Growth;Gynecology;Health;health assessment;Health financing;Health Personnel;Health Policy;Health Status;Health system;Healthcare;High Prevalence;Histopathology;implementation research;improved;India;Infant;infant outcome;Infrastructure;innovation;Intervention;Knowledge;Laboratories;Lactation;Leadership;low and middle-income countries;Maternal and Child Health;Maternal Mortality;maternal outcome;medical schools;member;Methods;microbiome;Monitor;Morbidity - disease rate;mortality;Multi-Institutional Clinical Trial;National Institute of Child Health and Human Development;neonatal health;neonatal outcome;Neonatology;neurodevelopment;new technology;Newborn Infant;Nurses' Aides;Observational Study;offspring;Outcomes Research;Participant;Pediatrics;peer;Persons;Pharmacology;Placenta;Policies;Population;Population Heterogeneity;Pregnancy Outcome;pregnant;Pregnant Women;Premature Birth;Procedures;Productivity;Professional counselor;Protocols documentation;Public Health;Qualitative Research;Recording of previous events;recruit;Registries;Reproducibility;Research;Research Design;Research Personnel;Resource-limited setting;Resources;retention rate;Safety;scale up;Site;social;Strategic Planning;Students;successful intervention;Sustainable Development;Target Populations;Techniques;Translational Research;Universities;Woman;Women Status;Women's mortality;Workforce Development

PROJECT_TITLE: TJU-JNMC Global Network for Women's and Children's Health Research Unit


ADMINISTERING_IC: EB

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Clinical Research;Digestive Diseases;Networking and Information Technology R&D (NITRD);Nutrition;Obesity;Prevention

ORG_CITY: TALLAHASSEE

ORG_NAME: FLORIDA AGRICULTURAL AND MECHANICAL UNIV

ORG_STATE: FL

PHR: Relevance: The goal of this research is to develop and validate a comprehensive computer-based technology that will help medical trainees to practice their skills for an emerging endoscopy-based weight loss procedure known as endoscopic sleeve gastroplasty (ESG). ESG is a nonsurgical, incision-less, organ-sparing procedure that is safe and effective and can be performed in an outpatient facilty by either a gastroenterologist or a bariatric surgeon with rapid return to work. The proposed training technology for ESG will allow clinicians to learn the procedure in a risk-free manner on computers before application to patients, resulting in improved patient outcomes and reduced treatment costs.

PI_NAMEs: DE, SUVRANU  (contact)

PROGRAM_OFFICER_NAME: BITTMANN, MORIA FISHER

PROJECT_TERMS: 3-Dimensional;Adoption;Algorithms;American;Anatomy;Animals;apprenticeship;Auditory;bariatric surgery;Bariatrics;Body mass index;Body Weight decreased;Cadaver;Certification;Chronic;Clinical;Cognitive;cognitive task;combat;comorbidity;Competence;Complex;Computer Models;Computers;Controlled Environment;cost;Cues;Data;Decision Making;Defect;design;Development;Devices;Diagnostic;Disease;Education;Educational Curriculum;Eligibility Determination;Endoscopes;Endoscopy;Environment;esophageal stents;Esthesia;Excision;experience;experimental study;Family suidae;FDA approved;Feedback;Fistula;flexibility;force feedback;Gastric Bypass;Gastroenterologist;gastrointestinal;Gastroplasty;Goals;haptic interface;haptics;Healthcare;high risk;improved;in vivo;innovation;instrument;Interdisciplinary Study;Intervention;Knowledge;Learning;Learning Skill;lifestyle intervention;Manufacturer;Measures;Medical;Mentors;Modeling;Morbid Obesity;Mucous Membrane;multidisciplinary;neurobehavioral;Obesity;Obesity Epidemic;Operative Surgical Procedures;Oral;Oral cavity;Organ;Outpatients;participant enrollment;Patient-Focused Outcomes;Patients;Perforation;Performance;Pharmacotherapy;Physics;Procedures;Process;Professional Organizations;Recovery;Recurrent disease;Regimen;Relapse;Research;Research Project Grants;Risk;Risk Reduction;Safety;sample fixation;simulation;simulation environment;skills;Specific qualifier value;Specimen;Standardization;Stents;Stomach;Surgeon;Surgical complication;Surgical sutures;System;task analysis;Task Performances;Technical Expertise;Techniques;Technology;Testing;Thick;Time;Tissues;tool;Touch sensation;Training;Translating;Treatment Cost;treatment strategy;Validation;virtual;virtual environment;virtual patient;virtual reality;Visual;Weight Gain;Work

PROJECT_TITLE: Development and Validation of a Virtual Bariatric Endoscopic (ViBE) simulator

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Eye Disease and Disorders of Vision;Immunotherapy;Orphan Drug;Rare Diseases

ORG_CITY: EL PASO

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF TEXAS EL PASO

ORG_STATE: TX

PHR: SOCS1 is a crucial regulator for uveal melanoma response to immunotherapy PROJECT NARRATIVE Downregulation of the suppressor of cytokine signaling 1 (SOCS1) and major histocompatibility complex (MHC) molecules was observed in uveal melanoma (UM) tumors derived from patients who did not respond to checkpoint inhibitors (CPIs), which provided a strong rationale for applying small SOCS1 modulators as potential therapeutics to enhance CPIs activities against metastatic UM. Herein, we proposed a comprehensive study to identify the distinct SOCS1-associated immune signature of UM and develop effectively combinational immune therapies with small SOCS1 modulators to enhance CPI anticancer immunity. Moreover, the research platform developed in this study can be directly applied to develop novel immunotherapies for head and neck cancer, breast cancer, liver cancer, and CM, in which SOCS1 plays a crucial role in the tumor progression and patient's overall survival.

PI_NAMEs: QIN, YONG  (contact)

PROGRAM_OFFICER_NAME: CUPIT, PAULINE

PROJECT_TERMS: Address;anti-cancer;antitumor effect;Biological Markers;Biological Response Modifiers;Cancer Center;cancer type;chemotherapy;CISH gene;Clinical;Clinical Markers;Clinical Research;Collaborations;Cutaneous Melanoma;Cytokine Signaling;Cytotoxic T-Lymphocytes;Data;Death Rate;Diagnosis;diagnostic accuracy;Down-Regulation;Drug resistance;Drug Targeting;effective therapy;Effectiveness;Epigenetic Process;Eye;FDA approved;Gene Expression;Genetic Transcription;Goals;Head and Neck Cancer;I-antigen;Immune;immune cell infiltrate;Immune checkpoint inhibitor;immune resistance;Immune response;Immune system;immunogenicity;immunoregulation;Immunotherapy;improved;Inflammatory;kinase inhibitor;Knowledge;Major Histocompatibility Complex;Malignant Breast Neoplasm;Malignant neoplasm of liver;Malignant Neoplasms;Measurable;melanocyte;Melanoma;Melanoma Cell;Melanoma patient;Melanoma Tumor;new combination therapies;new therapeutic target;novel;novel strategies;novel therapeutic intervention;patient response;Patients;Pharmaceutical Preparations;Play;pre-clinical;predictive marker;Prevention;Prognostic Marker;programs;Research;Resistance;responders and non-responders;response;Role;Signal Pathway;small molecule;Systemic Therapy;targeted treatment;Therapeutic;Time;translational potential;Translational Research;translational study;treatment comparison;tumor;Tumor Immunity;tumor microenvironment;tumor progression;Tumor Suppressor Proteins;Tumor-Derived;tumor-immune system interactions;Up-Regulation;Uvea;Uveal Melanoma;Uveal Neoplasms;Variant


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_CITY: SAINT LOUIS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative This proposal for mentored career development is designed to train the principal investigator in order to confer the skills necessary to be a successful independent investigator. The first focus is on commitment to ensuring that the principal investigator receives the mentorship and training to address any gaps in technical knowledge and ensure attainment of skills required of an independent biomedical investigator. The second focus is on understanding previously unexplored mechanisms of immune cell recruitment to the heart after injury.

PI_NAMEs: KOENIG, ANDREW LEIGHTON (contact)

PROGRAM_OFFICER_NAME: CHEON, YEWON

PROJECT_TERMS: Address;adverse outcome;Advisory Committees;Antigen-Antibody Complex;Award;beta-Chemokines;Cardiac;Cardiac Myocytes;cardioprotection;Cardiovascular Diseases;career;career development;Cause of Death;cell type;Cells;chemokine receptor;Computational Biology;Dendritic Cells;design;Development;Developmental Biology;Disease;Disease Progression;Doctor of Philosophy;Embryo;Ensure;Event;experimental study;Fibrosis;Foundations;gain of function;Gene Expression Profile;Genetic;Genetic Transcription;Goals;Grant;Heart;Heart failure;heart function;Heart Injuries;Hematopoietic stem cells;Homeostasis;Human;Hypertrophy;Image;Immune;Immune response;Immunology;improved outcome;indexing;Infarction;Infiltration;Inflammation;Inflammatory;Inflammatory Response;Injury;Interferon Activation;interferon alpha receptor;Interferon Type I;Interferons;Knowledge;Left Ventricular Remodeling;Literature;loss of function;Macrophage;Maps;Mentors;Mentorship;Minor;monocyte;Morphology;Mus;Myocardial;Myocardial Infarction;myocardial injury;Myocarditis;Myocardium;new technology;Persons;Phase;Play;Population;Population Dynamics;post-doctoral training;prevent;Principal Investigator;recruit;repaired;Reporter;Research;Research Personnel;Role;Signal Transduction;single-cell RNA sequencing;skill acquisition;skills;spatiotemporal;Specific qualifier value;success;Technical Expertise;Techniques;Technology;Testing;therapeutic target;therapy development;Time;tissue repair;Tissues;tool;Training;two-photon;United States;Writing

PROJECT_TITLE: Fate-mapping of Cardiac Monocyte Recruitment and Specification

STUDY_SECTION: MTI

STUDY_SECTION_NAME: NHLBI Mentored Transition to Independence Study Section[MTI(MA)]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Behavioral and Social Science;Clinical Research;Digestive Diseases;Emerging Infectious Diseases;Health Services;Infectious Diseases;Machine Learning and Artificial Intelligence;Pediatric

ORG_CITY: CHAPEL HILL

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE This project focuses on antibiotic use for treatment of diarrheal disease among children and the relationship to the development of antibacterial resistance in rural China. With data from an audit study in clinics and pharmacies and a micro-level survey of households in southwest China, I will explore the drivers of antibiotic use, both on the supply side with clinicians and pharmacists and the demand side among parents and caregivers, using machine learning-based quasi-experimental statistical analysis and agent-based modeling to identify various drivers of antibiotic demand, to simulate the effects of alternative policies on antibiotic use and antibiotic resistance, and to identify promising policies and interventions for future study. The outcomes of this research will contribute to knowledge of the behavioral drivers of population-level antibiotic use and resistance and support the development of policies and interventions suited to low and middle-income countries.

PI_NAMEs: SYLVIA, SEAN Y (contact)

PROGRAM_OFFICER_NAME: HUNTLEY, CLAYTON C

PROJECT_TERMS: Address;Adverse event;Affect;Age;analytical tool;Antibiotic Resistance;Antibiotics;Antimicrobial Resistance;Area;Automobile Driving;Bacterial Drug Resistance;bacterial resistance;Behavioral;behavioral response;Calibration;career;Caregivers;Characteristics;Child;Childhood;China;Clinic;Clinical;Communities;community setting;community-level factor;Complex;cost;Country;Data;Data Analyses;design;Development;development policy;Diagnostic;Diarrhea;diarrheal disease;Disease;Drug toxicity;Economics;effective intervention;Effectiveness;Epidemiology;Equilibrium;experience;experimental study;Exposure to;Face;Feces;Future;global health;Goals;gut microbiota;health care quality;health seeking behavior;Health system;Household;Hydration status;Immune system;Improve Access;Incentives;Income;Individual;Infectious Disease Epidemiology;infectious disease model;insight;Intervention;Knowledge;Learning;Link;low and middle-income countries;Machine Learning;Marketing;Mentored Research Scientist Development Award;Mentors;Modeling;models and simulation;Mortality Decline;Nature;Oral;Outcomes Research;Parents;Patients;Pharmacists;Pharmacy facility;Policies;Population;population based;Positioning Attribute;Prevalence;prevent;programs;Provider;Psychological reinforcement;Quality of Care;Quasi-experiment;Rapid diagnostics;Recommendation;Research;Research Activity;Resistance;Resistance development;Rural;Series;Side;simulation;social;Social Sciences;Source;Standardization;Statistical Data Interpretation;structural determinants;Superbug;Surveys;System;Techniques;Testing;Time;Training;Training Activity;United States National Institutes of Health;Work

PROJECT_TITLE: Understanding the Drivers of Antibiotic use in the Treatment of Childhood Diarrhea and Relationship to Antibiotic Resistance in China

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases B Research Study Section[MID-B]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Mental Health;Mental Illness;Pediatric;Serious Mental Illness;Sleep Research

ORG_DEPT: PSYCHIATRY

PHR: PROJECT NARRATIVE Early childhood depression symptoms are a significant public health concern as they are associated with functional impairments and heightened risk for depression across the lifespan. This project will comprehensively examine sleep in an ascertained sample of 3-year-olds oversampled for familial risk for depression, examining whether objectively measured sleep/circadian rhythms are markers of early childhood depression and whether sleep disturbances in infancy/toddlerhood are developmental precursors of early childhood depression at age 3. This project represents an unexplored, but vitally important area of research that may have substantial impact on our understanding of risk for early childhood depression, as well as our ability to identify children who may be suffering from early childhood depressive symptoms.

PI_NAMEs: HOYNIAK, CAROLINE PAIGE (contact)

PROGRAM_OFFICER_NAME: BECHTHOLT, ANITA JEAN

PROJECT_TERMS: 3 year old;actigraphy;Adult;Age;Area;associated symptom;Biological Markers;biomarker identification;Birth;career;Caregivers;Characteristics;Child;child depression;Chronic;circadian;Circadian desynchrony;Circadian Rhythms;Clinical;cohort;Collection;Data;Data Analyses;Data Collection;density;depressive symptoms;Development;Diagnosis;diaries;Disease;early childhood;Early Diagnosis;Early Intervention;early life adversity;Environment;falls;Functional impairment;Funding;Goals;high risk;Home;improved;Individual;infancy;Infant;innovation;Knowledge;life span;Light;maternal depression;Measurable;Measures;Mental Depression;Mental Health;Mentors;Methodology;Middle Insomnia;Modification;Mothers;multidisciplinary;Napping;National Institute of Mental Health;novel;Parents;Phenotype;Polysomnography;poor sleep;Positioning Attribute;prenatal;prospective;Psychopathology;Public Health;rapid eye movement;Relapse;Reporting;Research;Research Activity;Risk;Role;Sampling;Schedule;Science;Scientist;Sleep;sleep abnormalities;Sleep Architecture;Sleep disturbances;sleep onset;Slow-Wave Sleep;Statistical Data Interpretation;Symptoms;System;Techniques;Testing;Toddler;Training;Training Activity;virtual;Youth

PROJECT_TITLE: Sleep Disturbances and Circadian Misalignment as Potential Markers of Early Childhood Depression

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Liver Disease;Nutrition;Obesity;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research;Substance Misuse

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

ORG_STATE: CA

PHR: PROJECT NARRATIVE Alcohol- (ALD) and non-alcoholic fatty liver disease (NAFLD) constitute the majority of liver-related morbidity and mortality. Based on national trends of increasing obesity and harmful alcohol use, the health burden of NAFLD and ALD is projected to rise, particularly among women, young adults, and under-represented minorities. This proposal directly addresses these overlapping epidemics through the lens of liver fibrosis (the most significant predictor of patient outcomes in ALD and NAFLD) by examining: (i) the longitudinal interactions of alcohol and metabolic risks on liver fibrosis, aiming to provide more individualized prognostic information; (ii) proprotein convertase subtilisin kexin type 9 (PCSK9), a novel biomarker and potential therapeutic target in ALD.

PI_NAMEs: LEE, BRIAN PEI LIM (contact)

PROGRAM_OFFICER_NAME: WANG, JOE

PROJECT_TERMS: Accounting;Achievement;addiction;Address;Adult;Age;Alcohol consumption;alcohol effect;Alcohols;Algorithms;Alleles;Behavioral;Biological Markers;biomarker validation;Biometry;Biostatistical Methods;biracial;Black Populations;Black race;Blood specimen;Body mass index;Body Weight decreased;Breakthrough device;California;Cardiovascular Diseases;Cardiovascular system;Caring;Categories;Cessation of life;Characteristics;Cholesterol;chronic liver disease;Clinical;Clinical Research;Clinical stratification;Clinical Trials;cohort;Communities;Complex;Coronary Artery Risk Development in Young Adults Study;Data;Deposition;design;Diabetes Mellitus;Diagnosis;Disease;disease diagnosis;Disease Progression;Educational workshop;effective intervention;end stage liver disease;Ensure;Environment;Epidemic;Etiology;experience;Fatty acid glycerol esters;FDA approved;Fibrosis;follow-up;Foundational Skills;Funding;Future;Genetic;Genetic Carriers;genetic epidemiology;Genetic Markers;Genotype;Goals;Guidelines;Health;Heavy Drinking;Hepatic Fibrogenesis;Hepatitis;high risk;Histologic;Histology;Human;Hyaluronic Acid;improved;Incidence;Individual;Inflammation;inhibitor;Injury;interest;Intervention;Investigation;Knowledge;Knowledge acquisition;Lead;Learning;lens;Liver;Liver diseases;Liver Fibrosis;liver injury;longitudinal analysis;Longitudinal Studies;Low Prevalence;Malignant Neoplasms;Matrix Metalloproteinase Inhibitor;Measures;Medical Care Costs;men;Mentors;Mentorship;Metabolic;Modeling;Monitor;Morbidity - disease rate;mortality;multidisciplinary;non-alcoholic fatty liver disease;novel;novel marker;Obesity;Other Genetics;Outcome;Participant;Patient-Focused Outcomes;Peptides;personalized approach;personalized intervention;personalized medicine;Persons;pharmacologic;Population;Positioning Attribute;prevent;Procollagen;Productivity;prognostic;prognostication;Proprotein Convertases;prospective;Questionnaires;Race;racial difference;racial disparity;Rattus;Recommendation;recruit;Registries;Research;Research Personnel;Risk;Role;Sampling;screening;Serum;Serum Markers;sex;sex disparity;statistics;Steatohepatitis;Structure;Subtilisins;Surveys;Testing;therapeutic target;Time;Tissues;Training;translational study;trend;Underrepresented Minority;United States;United States National Institutes of Health;Universities;Woman;young adult

PROJECT_TITLE: Estimating the Contribution of Alcohol and Metabolic Risk to Liver Disease Progression to Inform Personalized Interventions

STUDY_SECTION: AA

STUDY_SECTION_NAME: Biomedical Research Study Section[AA-1]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Infectious Diseases;Microbiome;Prevention

ORG_CITY: CAMBRIDGE

ORG_NAME: ADA FORSYTH INSTITUTE, INC.

ORG_STATE: MA

PHR: Narrative: The proposed research focuses on prevention of dental caries through targeted treatment of acid- producing bacteria (t-TAB). Its goal will be achieved by formulating and developing a series of pH-sensitive quaternary pyridinium salts and transforming the traditional, non-pH-sensitive chlorhexidine into antimicrobial materials with t-TAB capability. The successful candidates capable of preventing acid-induced tooth damage through achieving a healthy microbial community and maintaining environmental pH above 5.5 will be identified using a multispecies biofilm model that simulates human oral microbial community and further assessed for caries prevention in vitro using a microbial-caries model on human enamel and in vivo through a well-developed mouse caries model .

PI_NAMEs: HE, XUESONG ;SUN, JIRUN  (contact)

PROGRAM_OFFICER_NAME: MCNEALY, TAMARA L

PROJECT_TERMS: Acceleration;Acids;acronyms;Advanced Development;Affect;analog;Animal Model;anti-microbial drug;antimicrobial;Antimicrobial Effect;aqueous;Bacteria;bactericide;base;Biomass;biomaterial compatibility;Buffers;Carbohydrates;Carbon;Caries prevention;cariogenic bacteria;Chemical Structure;Chemistry;Chlorhexidine;Chronic;Clinical;Collaborations;Communicable Diseases;cost;demineralization;Dental caries;Dental Clinics;Dental Enamel;design;Development;Dietary Carbohydrates;dysbiosis;effective therapy;Effectiveness;effectiveness evaluation;Encapsulated;environmental change;Feedback;Future;Goals;Growth;Human;improved;In Vitro;in vivo;Infection prevention;innovation;Intake;Kinetics;Knowledge;lead candidate;Length;microbial;Microbial Biofilms;microbial community;microbial composition;microbiome;Modeling;Monitor;multidisciplinary;Mus;Names;nanoparticle;novel;Oral;oral microbial community;Particle Size;Physiological;polymicrobial biofilm;polymicrobial disease;prevent;Production;Property;Research;research clinical testing;resident commensals;response;Saliva;Salts;Series;Silicon Dioxide;Sodium Chloride;Solubility;Stimulus;Streptococcus mutans;Sucrose;Surface;Tail;targeted treatment;Testing;Tooth structure;Translating;treatment comparison;treatment optimization;Water;water solubility

PROJECT_TITLE: Preventing dental caries through targeted treatment of acid-producing bacteria

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]


NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Cardiovascular;Clinical Research;Heart Disease;Hematology;Immunotherapy;Lymphatic Research;Lymphoma;Orphan Drug;Rare Diseases

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE This project aims to define the relationship of Bruton’s tyrosine kinase (BTK) inhibitor initiation to adverse changes in cardiac remodeling that are linked to atrial fibrillation. These studies are also relevant to public health because they may lead to a more clear understanding of how cardiovascular disease develops following initiation of this increasingly ubiquitous class of drug, while critically informing clinicians and cancer patients on the safety of an innovative strategy for the prevention of potentially devastating cardiotoxic events.

PI_NAMEs: ADDISON, DANIEL  (contact)

PROGRAM_OFFICER_NAME: WEBB, STEPHANIE JOHNSON

PROJECT_TERMS: Adult;Affect;Agammaglobulinaemia tyrosine kinase;Age;Ambulatory Blood Pressure Monitoring;animal data;Animal Model;Animals;Anticoagulants;Aorta;Arrhythmia;Atrial Fibrillation;Biological Markers;Blood Pressure;blood pressure elevation;Blood Vessels;Breast;cancer immunotherapy;Cancer Patient;Cardiac;cardiac magnetic resonance imaging;Cardiotoxicity;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;career;Chronic Lymphocytic Leukemia;Clinical;Clinical Data;cohort;cytokine;Data;Development;Disease;Drug Interactions;Early Diagnosis;Event;Expectancy;Fibrosis;follow-up;Gender;Generations;Heart Atrium;Heart Research;Hemorrhage;Hypertension;imaging study;Imaging Techniques;improved;Incidence;Inflammation;Inflammatory;inhibitor therapy;innovation;insight;Interleukin-6;Lead;Left;Left Atrial Function;Left Ventricular Ejection Fraction;Left Ventricular Mass;Legal patent;Link;Lung;Malignant Neoplasms;Matrix Metalloproteinases;Measurement;Measures;Monitor;multidisciplinary;myocardial damage;novel;Oncology;Oxidative Stress;Pathway interactions;Patients;Pharmaceutical Preparations;Prevention strategy;primary endpoint;primary outcome;prospective;Prospective Studies;protein-tyrosine kinase c-src;Public Health;Reporting;Research;response;Risk;Safety;Serum;Signal Transduction;Specific qualifier value;standard of care;Testing;TNF gene;tool;Transforming Growth Factor beta;Troponin;Troponin I;Tyrosine Kinase Inhibitor;Ventricular;Work

PROJECT_TITLE: Early Detection and Mechanisms of Cancer Immunotherapy Associated Cardiotoxicity

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(MA)]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Genetics;Heart Disease;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: PROJECT NARRATIVE Heart failure is a debilitating medical condition characterized by the inability of the heart to supply blood to the body and critical organs. The number of people developing heart failure continues to increase worldwide and, despite intense efforts to improve the treatment of heart failure, death rates remain high. Although multiple complex causes lead to heart failure, oxidative stress is a common feature and by leveraging the strength of a newly characterized animal model that allows on demand generation of oxidative stress in the heart, I aim to define how oxidative stress leads to heart failure with the long-term goal to find novel therapies for this devastating disease.

PI_NAMEs: SPYROPOULOS, FOTIOS  (contact)

PROGRAM_OFFICER_NAME: WANG, WAYNE C

PROJECT_TERMS: Acetylation;Acute;Adult;Affect;Alanine;Amino Acids;Animal Model;Animals;Antioxidants;Applied Skills;Award;Bioenergetics;Biological Assay;Biology;Blood Vessels;Bypass;Calcium;Cardiac;Cardiac Myocytes;Cardiovascular Physiology;Cardiovascular system;career development;Cell Respiration;Chronic;Clinical;Clinical Investigator Award;Complex;Complication;D-Amino Acid Dehydrogenase;Data;Deacetylase;Death Rate;Dependence;Development;Disease;Dyes;Environment;Enzymes;Equilibrium;experience;Experimental Models;extracellular;fluorescence imaging;Fluorescent Probes;Functional disorder;Funding;Future;Generations;Genetic;Goals;Heart;Heart failure;heart function;hemodynamics;Hospitals;Human;Hydrogen Peroxide;Immunoprecipitation;Impairment;improved;In Vitro;in vivo;Injury;insight;Institution;Investigation;K-Series Research Career Programs;Knowledge;Laboratories;Lead;Link;live cell imaging;Manuscripts;Measures;Mediating;Medical;medical schools;meetings;Membrane Potentials;Mentors;Mentorship;Messenger RNA;Metabolic;Mitochondria;mitochondrial dysfunction;Modeling;Modification;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;Myocardium;Neonatal;new therapeutic target;novel;novel therapeutics;Organ;oxidant stress;Oxidants;oxidation;Oxidative Stress;Oxidative Stress Induction;Pathway interactions;Pattern;perinatal medicine;Persons;Phenotype;Physiology;Predisposition;premature;Premature Birth;Premature Infant;pressure;Prevention;Prevention therapy;Principal Investigator;Protein Acetylation;Proteins;Quality of life;Reactive Oxygen Species;Recombinants;Regulation;release of sequestered calcium ion into cytoplasm;Research;Resources;response;Role;Scholarship;Scientist;Senior Scientist;Signal Transduction;Sirtuins;SOD2 gene;Superoxides;Testing;Time;timeline;Tissues;Training;Training Programs;Transgenic Mice;Vascular blood supply;Viral Vector;Virus;Western Blotting;Woman;Work;Writing;Yeasts

PROJECT_TITLE: Oxidative Stress and Mitochondrial Dysfunction in Chemogenetic Heart Failure

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(JA)]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE The Cancer Biology, Informatics & Omics (CBIO) training program prepares the next-generation of scientists with the knowledge, skills and proficiency in designing and executing research that incorporates the collection, analysis and interpretation of large-scale omics data to investigate the complex biology of cancer and to drive further advancement in precision cancer medicine. CBIO has leveraged the outstanding research, teaching and technology-innovation environment at the University of California, San Diego Health Sciences (UCSDHS) to establish a program that adds value to trainee education, career development, faculty interactivity and computational biology research in the UCSDHS community. By building on its successes and with regular, formalized, program evaluations by External and Internal Advisory Committees, trainees and faculty, CBIO will continue to develop and streamline training activities to fulfill its mission as a catalyst of research education at the forefront of informatics- and omics-driven cancer research.

PI_NAMEs: WANG, JEAN Y.J. (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TITLE: Cancer Biology, Informatics & Omics (CBIO) Training Program

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences;Pediatric

ORG_CITY: MINNEAPOLIS

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative During adolescence the brain undergoes a profound reorganization, including the formation and stabilization of neural circuits that are critically involved in decision-making. Here, we use sophisticated in vivo methods to interrogate the functional developmental changes longitudinally across adolescence within a midbrain/amygdala- cortical neural network that mediates reinforcement-learning computations to guide value-based choice.

PI_NAMEs: GROMAN, STEPHANIE MARY;SAUNDERS, BENJAMIN THOMAS (contact)

PROGRAM_OFFICER_NAME: VAZIRI, SIAVASH

PROJECT_TERMS: Adolescence;Adolescent;Adult;Age;age related;Amygdaloid structure;Anterior;Attention;awake;Behavior;Brain;Brain imaging;Brain region;Calcium;cingulate cortex;Clinical;Complex;computational reasoning;Computer Models;Coupled;critical period;Data;Decision Making;Development;Dimensions;Fiber;Future;Image;imaging study;improved;in vivo;in vivo calcium imaging;in vivo optical imaging;Individual;innovation;insight;Learning;Link;Mediating;Mental disorders;Methods;Midbrain structure;neural;neural circuit;neural network;neurodevelopment;Neurons;optogenetics;Outcome;Photometry;Population;postnatal;Prefrontal Cortex;Process;Proto-Oncogene Proteins c-abl;Psychological reinforcement;Rattus;Reporting;Reversal Learning;Rewards;Role;Signal Transduction;Site;ST5 gene;Synapses;System;Techniques;Testing;translational study;transmission process;Update;Ventral Tegmental Area;Viral;Virus

PROJECT_TITLE: Circuit-level neurodevelopmental trajectories of decision-making computations across adolescence

STUDY_SECTION: LMDN

STUDY_SECTION_NAME: Learning, Memory and Decision Neuroscience Study Section[LMDN]


NIH_SPENDING_CATS: Aging;Cardiovascular;Heart Disease

ORG_CITY: Aurora

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: A decline in the pacemaker activity of the sinoatrial node of the heart is an inherent property of cardiovascular aging which is associated with cardiovascular morbidity, cognitive dysfunction, decreased functional independence, and reduced health span. Proposed studies will define the biophysical and molecular mechanisms in cardiac pacemaker cells that cause the heart to slow with age. Understanding these mechanisms is essential for the development of improved therapies to treat age-related bradycardia.

PI_NAMEs: PROENZA, CATHERINE  (contact)

PROGRAM_OFFICER_NAME: BALIJEPALLI, RAVI C

PROJECT_TERMS: Action Potentials;Address;Aerobic;Age;age related;age related changes;aged;Aging;Alternative Therapies;Biophysical Process;Biophysics;Bradycardia;Cardiac;Cardiac Myocytes;Cardiac pacemaker;Cardiovascular system;Cell membrane;Cells;Cerebrum;Closure by clamp;Complement;Computer software;cost;Custom;Cyclic AMP;Data;defined contribution;Dependence;Development;Diastole;dynamic system;Elderly;electronic pacemaker;Electrophysiology (science);experimental study;functional independence;Funding;Gender;genetic regulatory protein;Goals;Guanylate kinase;HCN4 gene;Health;Health Care Costs;healthspan;Heart;Heart Rate;Human;Impaired cognition;Implant;improved;Individual;Injury;inorganic phosphate;Inositol;insight;Ion Channel;knock-down;Knock-out;Life Style;Link;Mediating;Microprocessor;mimetics;Molecular;Morbidity - disease rate;Mus;Muscle Cells;Neurons;nodal myocyte;normal aging;novel;old mice;Older Population;Operative Surgical Procedures;Pacemakers;patch clamp;Phase;Phenotype;Physical Fitness;Physiological;Process;programs;Property;receptor;Regulation;Research;response;Rest;Risk;Shapes;Signal Transduction;Sinoatrial Node;Societies;Syncope;System;Techniques;Testing;Time;tool;voltage;Work

PROJECT_TITLE: Regulation of excitability in sinoatrial myocytes

STUDY_SECTION: NTRC

STUDY_SECTION_NAME: Neurotransporters, Receptors, and Calcium Signaling Study Section[NTRC]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cardiovascular;Congenital Heart Disease;Congenital Structural Anomalies;Heart Disease;Infant Mortality;Lung;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Pediatric;Pulmonary Hypertension;Rare Diseases

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative Tetralogy of Fallot is a congenital heart disease affecting 1 in 3600 births that is typically repaired with surgery early in life. Although advances in care have greatly improved patient survival, there is limited understanding of which patients will experience adverse events related to right ventricular remodeling, resulting in reduced quality of life, increased healthcare burden, and increased mortality. The proposed research introduces a multi-faceted approach using machine learning and computational fluid dynamics to identify the structural and hemodynamic parameters of tetralogy of Fallot that are associated with right ventricular remodeling.

PI_NAMEs: THOMPSON, ELIZABETH WALKER (contact)

PROGRAM_OFFICER_NAME: MEADOWS, TAWANNA

PROJECT_TERMS: 3-Dimensional;Adverse event;Affect;Algorithms;Anatomy;automated segmentation;Birth;Blood;Cardiac;Cardiac Volume;Cardiology;Cardiovascular Diseases;Cardiovascular Physiology;Cardiovascular system;Caring;Child;Cicatrix;Clinical;clinical care;Cohort Studies;congenital heart abnormality;Consumption;Cross-Sectional Studies;Cyanotic heart disease;Data;Defect;Dilatation - action;Disease;Engineering;Evaluation;Event;experience;follow-up;Functional disorder;Genetic;Geometry;Goals;healthcare burden;Heart;heart function;hemodynamics;HIF1A gene;Image;improved;insight;Intervention;Joints;Knowledge;Lead;Life;Liquid substance;longitudinal analysis;Machine Learning;machine learning algorithm;machine learning method;Magnetic Resonance;Magnetic Resonance Imaging;Manuals;Measurement;Mechanics;Medical;Medical Imaging;Mentorship;Modeling;mortality;mortality risk;Navier-Stokes equations;Operative Surgical Procedures;Outcome;outcome prediction;Outcome Study;Paris, France;Pathologic;Pathway interactions;Patient Care;patient subsets;Patients;Pediatric Hospitals;Phase;Philadelphia;Physicians;pressure;Process;Pulmonary artery structure;Pulmonary Valve Insufficiency;Pulmonary Valve Stenosis;Pulmonary valve structure;Quality of life;Radiology Specialty;repaired;Research;Research Personnel;Residual state;Resistance;Right Ventricular Dysfunction;right ventricular remodeling;Risk;Scientist;serial imaging;shear stress;simulation;skills;Stress;Structure;success;supervised learning;technology validation;Tetralogy of Fallot;Thick;Time;Training;two-dimensional;Variant;Ventricular;Ventricular Arrhythmia;Ventricular Function;Work

PROJECT_TITLE: Right Ventricular Remodeling in Tetralogy of Fallot


NIH_SPENDING_CATS: Biotechnology;Cancer;Digestive Diseases;Genetics;Pancreatic Cancer;Rare Diseases

ORG_CITY: OKLAHOMA CITY

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PHR: Project Narrative: Malic enzyme 2 is frequently deleted in pancreatic cancer and its deletion correlates with poor patient prognosis. Here, we propose experiments that will explore the molecular basis of malic enzyme 2 loss-induced oncogenesis of pancreatic cancer. Our studies will also identify novel therapies for patients with malic enzyme 2 loss and will lead to new clinical treatments for human pancreatic cancer.

PI_NAMEs: SINGH, PANKAJ KUMAR (contact)

PROGRAM_OFFICER_NAME: GHOSH-JANJIGIAN, SHARMISTHA

PROJECT_TERMS: Acceleration;Agreement;Binding;Biological Assay;Biological Markers;Cancer Etiology;cancer initiation;Cell Culture Techniques;cell growth;Cells;Cessation of life;chemotherapy;chromatin immunoprecipitation;Clinical Treatment;clinically relevant;Data;Data Set;Development;Diagnosis;Down-Regulation;effective therapy;Effectiveness;Event;experimental study;FRAP1 gene;gain of function mutation;Genes;Genetic;Genetically Engineered Mouse;Goals;Growth;high throughput screening;High-Throughput Nucleotide Sequencing;Human;Implant;implantation;improved;inhibitor;innovation;Invaded;kinase inhibitor;knock-down;Knock-out;KRAS oncogenesis;KRASG12D;Lesion;Libraries;MADH4 gene;malic enzyme;Malignant Breast Neoplasm;Malignant neoplasm of pancreas;Malignant Neoplasms;Mediating;Mediator;Modeling;Molecular;mouse model;Mus;Mutation;Neoplasm Metastasis;neoplastic cell;novel;novel therapeutics;Oncogenes;Oncogenic;Organoids;Other Genetics;pancreatic cancer cells;pancreatic cancer patients;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma model;Pancreatic Intraepithelial Neoplasia;pancreatic neoplasm;pancreatic PDX models;pancreatic tumorigenesis;patient derived xenograft model;patient prognosis;Patients;personalized biomarkers;personalized medicine;personalized therapeutic;pharmacologic;Phase;Phosphatidylinositols;Phosphotransferases;Primary Neoplasm;Production;Prognosis;promoter;Protein Array;Reactive Oxygen Species;Research Personnel;Residual state;Resistance;response;Role;Series;Signal Pathway;Signal Transduction;Sirolimus;The Cancer Genome Atlas;Therapeutic;three-dimensional modeling;transcriptome sequencing;Treatment Efficacy;treatment response;tumor;Tumor Burden;tumor growth;tumor progression;Tumor Suppression;Tumor Suppressor Proteins;tumorigenesis;tumorigenic;Xenograft Model

PROJECT_TITLE: Molecular Basis of ME2-mediated Tumor Suppression in Pancreatic Cancer

STUDY_SECTION: TCB

STUDY_SECTION_NAME: Tumor Cell Biology Study Section[TCB]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Immunotherapy;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: GAINESVILLE

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: NARRATIVE The glioma microenvironment is very complex and heterogeneous, a feature that impedes both the understanding of their biology as well as the elaboration of efficient clinical interventions. The focus of our proposal is to mechanistically understand the nature of the communications that take place in the tumor microenvironment, especially between immune suppressive cells and tumor cells that resist therapy but also to test the therapeutic effect of disrupting these interactions to treat brain tumors. The long-term goal of this project is to translate the information gained into strategies useful as clinical therapies improving disease outcome.

PI_NAMEs: DELEYROLLE, LOIC PIERRE (contact)

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: adipokines;aerobic glycolysis;Affect;anti-PD1 therapy;Apolipoprotein E;atorvastatin;Biology;Brain Neoplasms;C57BL/6 Mouse;cancer cell;cancer therapy;Cell Communication;Cell Compartmentation;Cell Cycle;Cell Lineage;Cell Physiology;Cell Shape;Cells;Cellular biology;Cellular Metabolic Process;chemotherapy;Clinical;clinically relevant;Communication;comparative;Complex;Coupled;cytokine;Dependence;digital;Disease;Disease Outcome;Disease Progression;Environment;Exhibits;experimental study;FABP3 gene;Fatty Acids;Flow Cytometry;Genetic;genomic profiles;Glioblastoma;Glioma;Glucose;Goals;Growth;Heterogeneity;Image;Immune;immune cell infiltrate;Immune checkpoint inhibitor;Immune system;Immunological Models;improved;In Vitro;in vivo;Induction of Apoptosis;insight;intercellular communication;Intervention;Investigation;Knockout Mice;Label;Laboratories;LCN2 gene;Link;lipid biosynthesis;lipid metabolism;lipid transport;Lipids;Logic;Macrophage;Maintenance;Malignant Neoplasms;Mediating;Metabolic;Mitochondria;Modeling;Molecular;Morbidity - disease rate;mortality;Mus;Myeloid-derived suppressor cells;Nature;neoplastic cell;novel therapeutics;Outcome;Oxidative Phosphorylation;Pathway interactions;Patients;pharmacologic;Phenotype;Play;Population;programs;Proliferating;recruit;Recurrence;Recurrent disease;Regulatory T-Lymphocyte;Reporting;Research Design;Resistance;Role;Shapes;Signal Transduction;single-cell RNA sequencing;Sorting;Specimen;standard of care;System;T-Lymphocyte;Technology;temozolomide;Testing;Therapeutic;Therapeutic Effect;therapeutic evaluation;therapy resistant;Time;transcriptomics;Transgenic Mice;Translating;tumor;tumor heterogeneity;Tumor Immunity;tumor microenvironment;tumor progression;Tumor Promotion;tumor-immune system interactions;tumorigenic;uptake;Work

PROJECT_TITLE: Metabolic interactions between tumor cells and the immunce system in GBM A potential Achilles heel of GBM for novel therapeutics

STUDY_SECTION: TME

STUDY_SECTION_NAME: Tumor Microenvironment Study Section[TME]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics

ORG_CITY: SANTA BARBARA

ORG_NAME: UNIVERSITY OF CALIFORNIA SANTA BARBARA

PHR: RELEVANCE (See instructions): Dysregulation of post-transcriptional regulation is very frequent in human cancers and other diseases, and usually it affects specific subsets of cells. Despite evidence for the importance of post-transcriptional regulation, it is almost completely unexplored at single-cell level. The goal of the proposed research is to develop new methodologies for characterising post-transcriptional regulation in single cells.

PI_NAMEs: FRANKS, ALEXANDER  (contact);SLAVOV, NIKOLAI

PROGRAM_OFFICER_NAME: YU, GUOQIN

PROJECT_TERMS: Address;Affect;Algorithms;Antibodies;Attenuated;Bar Codes;Binding Proteins;Biological;cell type;Cells;Cellular biology;Classification;Collaborations;Computer software;cost;Cytolysis;Data;data acquisition;Data Analyses;data modeling;Data Set;Dependence;Development;Dimensions;Disease;DNA Sequence;Education;Engineering;Environment;Evolution;experience;FMR1 gene;Fragile X Syndrome;functional group;Gene Expression;gene product;Genes;Goals;high throughput analysis;Human;Immune;improved;Inherited;Institution;Instruction;instrument;Ions;Joints;Liquid Chromatography;Maintenance;Malignant Neoplasms;Mammalian Cell;mammalian genome;Mass Spectrum Analysis;Measurement;Measures;Messenger RNA;method development;Methodology;Methods;Modeling;Molecular;Mutation;National Institute of General Medical Sciences;new technology;novel;Nucleic Acids;Peptides;Phenotype;Play;Post-Transcriptional Regulation;posttranscriptional;preservation;programs;protein aminoacid sequence;Protein Biosynthesis;protein degradation;Proteins;Proteome;Regulation;Reproducibility;Research;Resolution;response;Ribosomes;RNA;RNA Interference;RNA-Binding Proteins;Role;Sampling;Scanning;Shapes;Signal Transduction;single cell proteins;single cell technology;single-cell RNA sequencing;Statistical Models;Surveys;tandem mass spectrometry;Techniques;Technology;Testis;Tissues;tool;transcriptome;Transition Elements;Translating;Translational Regulation;Translations;Variant;Work

PROJECT_TITLE: Collaborative Research: DMS/NIGMS 2: Methods for Systematic Analysis of Post-transcriptional Regulation in Single Cells


NIH_SPENDING_CATS: Biotechnology

ORG_CITY: ATLANTA

ORG_DEPT: CHEMISTRY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative Heme enzymes catalyze a broad range of biological transformations important for immune system regulation, antibiotic production, and hormone biosynthesis. Elucidating their mechanistic behavior is therefore critical to understanding these pathways and developing new methods to combat disease. This proposal attempts to determine the structural basis for, and dynamics associated with, unusual heme-dependent enzyme reactions important for the development of new pharmaceuticals and anticancer therapeutics.

PI_NAMEs: DAVIS, KATHERINE MARIE (contact)

PROGRAM_OFFICER_NAME: SIMONOVIC, MILJAN

PROJECT_TITLE: Unraveling the dynamics that enable unusual heme enzyme reactivity


ORG_DEPT: GENETICS

PHR: Project Narrative Failed cytokinesis can promote tumor development and cause birth defects, and defects in vesicle trafficking contribute to diabetes and neurologic diseases. In addition, our studies on fungal-specific proteins such as glucan synthases and their regulators may reveal ideal targets for new antifungal drugs. Thus, understanding the crucial events and essential proteins that control successful completion of cytokinesis will help us discover the causes and possible treatments of cancer and other human health conditions.

PI_NAMEs: WU, JIAN-QIU  (contact)

PROGRAM_OFFICER_NAME: MILLER, RITA K

PROJECT_TERMS: Actins;Actomyosin;Affect;Animals;anti-fungal agents;beta-Glucans;Binding;Biochemical;Biological Assay;Biological Models;cancer therapy;Cell Differentiation process;Cell division;Cell membrane;Cell Nucleus;Cell Proliferation;Cell Separation;Cell Wall;Cells;Co-Immunoprecipitations;Complex;Congenital Abnormality;constriction;Cytokinesis;Darkness;Data;daughter cell;Defect;Deposition;Development;Diabetes Mellitus;Digestion;Electron Microscopy;electron tomography;Endocytosis;Enzymes;Equilibrium;Event;Exocytosis;experimental study;Extracellular Matrix;Filament;Fission Yeast;Funding;fungus;Genetic;glucan synthase;Goals;Health;Homeostasis;Human;improved;In Vitro;Label;Learning;Light;Link;Microscopic;Microscopy;Mitochondria;Molecular;Nervous System Disorder;novel;Pattern;Play;Principal Investigator;Proteins;recruit;Regulation;Resolution;rho GTPase-activating protein;Role;Series;Site;snRNP Structural Core Protein;Solid;spatiotemporal;Testing;Tissues;tomography;trafficking;Tumor Promotion;ultra high resolution;UNC13B gene;Vesicle;Work;Yeasts

PROJECT_TITLE: Molecular Mechanisms of Cytokinesis

STUDY_SECTION_NAME: Cell Structure and Function 1 Study Section[CSF1]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative Cells are the dynamic unit of life, interacting with their local and systemic environments and other cells. This proposal aims to develop a method combining optical and DNA barcodes, that enables the large-scale acquisition of dynamic single-cell information including cells’ spatiotemporal, morphological, and physiological changes, cell-cell interactions, and responses to the environment along with their single-cell omics data. Completing this proposal will offer new avenues to analyze single cells comprehensively.

PI_NAMEs: WU, YUE JANE (contact)

PROGRAM_OFFICER_NAME: NOVA, IAN CURTIS

PROJECT_TERMS: 3-Dimensional;Area;Bar Codes;Behavioral;Bioinformatics;biomaterial compatibility;Cancer Biology;cancer cell;cell behavior;Cell Communication;Cell Separation;Cells;Cellular biology;cellular imaging;Color;Data;Diagnosis;Dimensions;DNA;Effectiveness;Environment;epigenome;experience;General Hospitals;Genome;Growth;Harvest;Healthcare;Image;In Vitro;in vivo;in vivo imaging system;Individual;innovation;insight;Interdisciplinary Study;Lasers;Life;Location;Lymphatic Metastasis;Malignant Breast Neoplasm;Massachusetts;medical schools;Mentorship;Metastatic Neoplasm to Lymph Nodes;Methods;Microscope;Modality;Morphology;Multiomic Data;multiple omics;Mus;novel;Optics;particle;Phenotype;Physiological;Process;protein profiling;Proteome;Resolution;response;RNA;Semiconductors;Sentinel Lymph Node;sequencing platform;Shapes;single cell analysis;single cell sequencing;single-cell RNA sequencing;Slide;spatiotemporal;Speed;Systems Biology;Techniques;Technology;Time;Tissues;Training;transcriptome;transcriptomics

PROJECT_TITLE: Laser particles-based spatiotemporal and dynamic single-cell multiomics

STUDY_SECTION: GNOM

STUDY_SECTION_NAME: Genome Research Study Section[GNOM-G]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Eczema / Atopic Dermatitis;Neurosciences;Pain Research

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Project Narrative  Chronic itch represents a significant health and socioeconomic burden, affecting a large proportion of the US and world population. The present proposal will use preclinical mouse models to investigate the mechanisms that underlie the descending modulation of itch from the brainstem, as well as ascending transmission of itch signals from the spinal cord to higher centers, with an emphasis on neurons that express the receptor for substance P (NK-1 receptor). A better understanding of descending modulation and ascending transmission of itch has translational significance for the mechanisms-based development of more effective treatments for chronic itch, particularly those targeting the NK-1 receptor.

PI_NAMEs: CARSTENS, EARL E (contact)

PROGRAM_OFFICER_NAME: KOCH, PETER

PROJECT_TERMS: Acute;Affect;Atopic Dermatitis;Behavior;Behavioral;behavioral response;Brain Stem;Cells;Cervical;chronic itch;Clozapine;cost;designer receptors exclusively activated by designer drugs;Development;dorsal horn;Economic Burden;effective therapy;Electrophysiology (science);Fire - disasters;Genetic;genetic approach;health economics;in vivo;intradermal injection;Light;Mechanics;Mediating;Microinjections;Modeling;mouse model;Mus;Neurons;neurotransmission;novel;optical fiber;Optics;optogenetics;Pain;pain behavior;parabrachial nucleus;Pathway interactions;pharmacologic;Population;Posterior Horn Cells;pre-clinical;Presynaptic Terminals;Pruritus;Psoriasis;response;Role;Sensory;Signal Transduction;Site;Skin;socioeconomics;somatosensory;Spinal;Spinal Cord;Stimulus;Substance P;TACR1 gene;Testing;Thalamic structure;Touch sensation;transmission process;Withdrawal

PROJECT_TITLE: Role of NK-1 receptors in descending modulation and ascending transmission of itch

STUDY_SECTION: SPS

STUDY_SECTION_NAME: Somatosensory and Pain Systems Study Section[SPS]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Overview PROJECT NARRATIVE This Rheumatic Diseases Resource-based Core Center (RDRCC) provides systems and infrastructure to facilitate efficient and significant research on humans with rheumatic diseases. The synergies that arise from coupling the diverse and well-resourced research community to a rich collection of prospectively-collected data and samples from patients with rheumatic diseases through provision of Core service and expertise provides unprecedented opportunities to enhance and accelerate discovery into the causes, mechanisms, diagnosis, therapy and prevention in these diseases.

PI_NAMEs: BINGHAM, CLIFTON O;ROSEN, ANTONY  (contact)

PROGRAM_OFFICER_NAME: GARCIA-CAZARIN, MARY

PROJECT_TERMS: Acceleration;Arthritis;autoimmune rheumatologic disease;base;Biocompatible Materials;Biological;Biological Assay;Biological Markers;biomarker validation;Blood;cancer immunotherapy;Clinical;clinical care;clinical center;clinical investigation;Clinical Research;clinically relevant;cohort;Collaborations;Collection;Communication;Communities;Complex;Computerized Medical Record;Computing Methodologies;Coupling;Critical Pathways;Data;Data Analyses;data integration;Data Reporting;data repository;Data Science Core;Data Set;Databases;design;Diagnosis;Diagnostic;Disease;Disease Pathway;disorder subtype;Ecosystem;Education;electronic medical record system;Environment;environmental change;experience;Fostering;Funding;Goals;Heterogeneity;Human;Immunoassay;Immunology procedure;improved;Infrastructure;innovation;Institution;interdisciplinary collaboration;Interdisciplinary Study;Investigation;Investments;Laboratories;Leadership;literacy;longitudinal dataset;Lupus;Maps;Measurement;Methodology;Methods;Modeling;Modernization;Myositis;Operations Research;Outcome;Pathway interactions;patient oriented;Patients;phenotypic data;Philosophy;Population;precision medicine;Precision Medicine Initiative;Prevention;prognostic;programs;prospective;recruit;Research;Research Design;Research Personnel;Resources;Rheumatism;Rheumatology;Sampling;Scholarship;Scleroderma;Services;Sjogren's Syndrome;skills;Statistical Methods;Structure;Subgroup;synergism;System;Technology;Time;Tissues;tool;Translating;translational approach;translational pipeline;Translational Research;treatment response;Validation;Vasculitis;Work

PROJECT_TITLE: Johns Hopkins Rheumatic Diseases Resource-based Core Center (Johns Hopkins RDRCC)


ORG_CITY: STANFORD

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative Patient-derived tumor organoids (PDO), involving the ex vivo culture of fresh tumor fragments, have emerged as promising models for predicting patient drug response for personalized cancer therapy. Our work on a novel micro-dissection device to mechanically dissect fresh tumor specimen into uniform live micro-fragments for PDOs will reduce pre-analytical variations in PDO cultures, and increase the yield and quality of PDOs for downstream analyses, drug screens and biobanking. Upon validation, our work can lead to the standardization of the mechanical dissection process and micro-fragment size for PDOs, a critical step for broadening the clinical adoption of PDO technology for personalized cancer therapy.

PI_NAMEs: TANG, SINDY KAM-YAN (contact)

PROGRAM_OFFICER_NAME: GUAN, PING

PROJECT_TERMS: Address;Adoption;Antineoplastic Agents;Architecture;B-Lymphocytes;Benchmarking;biobank;Biological;Cancer Biology;cancer genome;Cause of Death;cell type;Cells;checkpoint inhibition;Clinical;Cryopreservation;cytotoxicity;Data;Devices;Diffusion;Digestion;Dissection;Drug Screening;Elements;experimental study;Fibroblasts;Flow Cytometry;Generations;Genomics;Geometry;Goals;Growth;high-throughput drug screening;Image;Immune;Immune checkpoint inhibitor;Immunofluorescence Immunologic;Immunotherapy;In Situ;in vivo;instrumentation;Ischemia;Kidney;Lead;Lung;Macrophage;Malignant Neoplasms;Manuals;Measures;Mechanics;Methods;Microdissection;Microfabrication;Modeling;nanofabrication;Natural Killer Cells;neoplastic cell;novel;Nutrient;Organoids;Outcome;Oxygen;patient response;Patients;Penetration;Performance;personalized cancer therapy;personalized immunotherapy;Pharmaceutical Preparations;Phenotype;Play;predictive modeling;preservation;Process;Quantitative Reverse Transcriptase PCR;reconstitution;Reproducibility;response;Role;Sampling;Silicon;Source;Specimen;Standardization;Stromal Cells;Surgical Pathology;T-Lymphocyte;Technology;Testing;Time;Tissue Banks;Tissues;tumor;tumor microenvironment;tumor progression;Tumor Tissue;Tumor-Infiltrating Lymphocytes;Validation;Variant;Work

PROJECT_TITLE: A micro-dissection platform for generating uniform-sized patient-derived tumor organoids (PDOs) for personalized cancer therapy


NIH_SPENDING_CATS: Arthritis;Autoimmune Disease

PI_NAMEs: ROSEN, ANTONY  (contact)

PROJECT_TERMS: Address;Architecture;Arthritis;autoimmune rheumatologic disease;base;Biological;cancer immunotherapy;career;Clinical;clinical care;Clinical Research;cohort;Collaborations;Collection;Communication;Communities;Data;Data Collection;data integration;data management;Data Reporting;Data Science;Diagnostic;Discipline;Disease;disorder subtype;Ecosystem;Environment;environmental change;experience;Fostering;Foundations;Funding;Goals;Heterogeneity;Human;Image;Immunoassay;improved outcome;Infrastructure;innovation;Institution;interest;Laboratories;Leadership;literacy;Logistics;Longitudinal cohort;Lupus;Lyme Disease;Measurement;Measures;medical specialties;Methods;Molecular;Myositis;novel;operation;Pathway interactions;Patient Care;Patients;precision medicine;programs;prospective;Psoriatic Arthritis;recruit;Research;Research Methodology;Research Personnel;Research Support;Resources;Retrieval;Rheumatism;Rheumatoid Arthritis;Rheumatology;Sampling;Scholarship;Scleroderma;Sjogren's Syndrome;Translational Research;treatment response;Vasculitis;Work

PROJECT_TITLE: Johns Hopkins RDRCC Administrative Core


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Pediatric;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: NEW YORK

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: Project Narrative The Aga Khan University/Columbia University Global Network site has played an important role in each of the Global Network studies and is responsible for both the conceptualization and leadership of several important research projects. In recent years, the Global Network has evaluated the value of ultrasound examinations during prenatal care, aspirin use to reduce preterm birth, a multi-micronutrient supplement to reduce childhood stunting, antibiotics during labor to reduce perinatal infections and the impact of COVID – 19 infections on pregnancy outcomes, all in the low and middle-income countries. The goal of future studies will be to continue to provide insight into the causes of adverse outcomes for women and children in low and middle-income countries, to evaluate medical and public health interventions designed to improve those outcomes and make data available so that the medical and public health systems in low and low-middle income countries can utilize the best evidence based interventions to improve the health of women and children.

PI_NAMEs: GOLDENBERG, ROBERT L (contact)

PROGRAM_OFFICER_NAME: CHAKHTOURA, NAHIDA ABDO

PROJECT_TERMS: adverse outcome;Antibiotics;Aspirin;Caring;Child;Child Health;Childhood;Cities;climate change;Cluster randomized trial;Collaborations;Communicable Diseases;Communities;Community Health;community research;cost effective intervention;Country;COVID-19 impact;Data;data quality;Dedications;Development;Education;Enrollment;Environment;Environmental Exposure;Environmental Health;Epidemiologist;Evidence based intervention;experience;follow-up;Funding;Future;Gestational Age;Goals;Government;Growth and Development function;Head;Health;health care availability;health care service;Health Policy;Health Sciences;Health system;Hospitals;Improve Access;improved;insight;Interdisciplinary Study;International;Intervention Studies;Intervention Trial;Laboratories;Leadership;low and middle-income countries;Maternal and Child Health;Maternal-fetal medicine;Measures;Medical;meetings;member;Mentors;Micronutrients;Monitor;Morbidity - disease rate;mortality;Multicenter Trials;multidisciplinary;New York City;Newborn Infant;Nutritional;Observational Study;Occupational Health;Outcome;Pakistan;Paper;Participant;Pathologist;pediatrician;Perinatal Infection;Play;population health;Population-Based Registry;Pregnancy;Pregnancy Outcome;Pregnant Women;Premature Birth;Prenatal care;Productivity;professor;protocol development;Protocols documentation;Public Health;public health intervention;Publications;Recording of previous events;recruit;Registries;Reporting;Reproductive Health;Research;Research Personnel;Research Project Grants;Research Support;Resource-limited setting;Resources;Risk Factors;Role;Rural;Rural Population;SARS-CoV-2 infection;Scientist;Senior Scientist;Services;Site;social;Specialist;Structure;success;therapy design;Training;trend;ultrasound;Uncertainty;Universities;Urban Hospitals;Urban Population;Woman;Women's Health;women's outcomes;Work

PROJECT_TITLE: Columbia University/Aga Khan University Global Network Research Unit


NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Bioengineering;Data Science;Networking and Information Technology R&D (NITRD);Precision Medicine;Scleroderma;Telehealth

PI_NAMEs: BINGHAM, CLIFTON O (contact)

PROJECT_TERMS: Acceleration;Address;analytical tool;Area;Big Data;biobank;Biologic Characteristic;Characteristics;Clinical;Clinical Research;clinically relevant;cohort;Collaborations;common rule;Complex;Consent;COVID-19;Data;data acquisition;Data Aggregation;Data Analyses;Data Collection;data harmonization;data integration;data modeling;data pipeline;Data Science;Data Security;Data Sources;data streams;Databases;Development;diagnostic platform;digital data;digital tool;Disease;disorder subtype;Documentation;electronic consent;Ensure;Environment;Event;experience;Faculty;Fostering;Foundations;Healthcare;Heterogeneity;Image;Imaging Device;immune-related adverse events;improved;Infrastructure;insight;Institution;Institutional Review Boards;Investments;Kinetics;Laboratories;Learning;Lupus;Malignant Neoplasms;Measurement;Medical Device;Medicine;Methods;multiple data sources;Myositis;novel;Outcome Measure;Participant;Pathogenesis;Pathway interactions;Patient Care;Patient Outcomes Assessments;patient subsets;Patients;Pattern;Phenotype;phenotypic data;point of care;precision medicine;Precision Medicine Initiative;Procedures;programs;Protocols documentation;Psoriatic Arthritis;Quality of life;quantitative imaging;recruit;Registries;Regulation;Research;Research Ethics;Research Personnel;research study;Resources;response;Rheumatism;Rheumatoid Arthritis;Rheumatology;Risk;risk stratification;Scleroderma;screening;Secure;Sjogren's Syndrome;Speed;Standardization;System;Techniques;Technology;Telemedicine;Therapeutic;Time;tool;treatment response;Universities;Vasculitis;wearable device;Work

PROJECT_TITLE: Precision Medicine Data Integration Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Neurodegenerative;Neurosciences;Rehabilitation

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: We propose to study episodic memory processing in parietal—hippocampal circuits in human intracranial EEG patients. We will use three innovative experimental approaches, including microelectrode recordings, cholinergic modulation, and direct brain stimulation, to address key knowledge gaps regarding the neurophysiological underpinnings of episodic processing in these circuits. Our approach builds directly on published and preliminary data collected in human subjects over the previous funded period.

PI_NAMEs: LEGA, BRADLEY C (contact)

PROGRAM_OFFICER_NAME: BABCOCK, DEBRA J

PROJECT_TERMS: Address;Affect;Alzheimer's Disease;angular gyrus;animal data;Animal Model;Anti-Cholinergics;Area;Attenuated;Autobiography;Brain;Cells;cholinergic;cingulate cortex;Collection;Coupled;Data;Data Set;Deep Brain Stimulation;Degenerative Disorder;Disease;Electrodes;Electroencephalography;Electrophysiology (science);Epilepsy;Episodic memory;Exhibits;experimental study;Foundations;Frequencies;Funding;Future;Goals;Hippocampus;Human;human data;human disease;human subject;imaging study;Individual;innovation;insight;Knowledge;Lateral;Measures;Medial;Memory;memory process;memory retrieval;Methods;Microelectrodes;Modeling;Monitor;nerve supply;Neurons;neurophysiology;neuroregulation;neurosurgery;non-invasive imaging;novel;Operative Surgical Procedures;Parietal;Parietal Lobe;Participant;patient population;Patients;Pattern;Phase;Placebos;Population;Process;Publishing;Ramp;rate of change;Reporting;Research;response;Retrieval;Rodent;Rodent Model;Scopolamine;Series;Signal Transduction;simulation;Steel;Structure;Testing;Therapeutic;Time;tool;Translating;Work

PROJECT_TITLE: Using deep brain stimulation of the parietal cortex to investigate the electrophysiology of human episodic memory


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Diabetes

ORG_CITY: IOWA CITY

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: PROJECT NARRATIVE Current diabetes treatments are woefully inadequate, and diabetes remains a leading cause of disability and death among Americans. Our program will meet a growing need within our region and the country for a cohort of capable diabetes investigators, by training new scientists in cutting edge research aimed at better treating and preventing diabetes. The trainees in this program will be scientists who are not yet independent but have earned their PhD and/or MD and intend to head their own diabetes research laboratories.

PI_NAMEs: NORRIS, ANDREW W (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Diabetes Mellitus;Research Training;Training Programs

PROJECT_TITLE: Diabetes Research Training Program

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Recovery Support Services;Rehabilitation;Substance Misuse;Telehealth

ORG_CITY: ALBUQUERQUE

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF NEW MEXICO

ORG_STATE: NM

PHR: NARRATIVE To address the public health burden of alcohol use disorder (AUD), there is a tremendous need for continuing care options to support long-term recovery from AUD that (1) support whole-person recovery, defined as focusing on both functioning and reductions in drinking or abstinence, (2) are effective in targeting the neuroadaptations observed among those with addiction, and (3) are accessible in all communities nationwide, including medically underserved and health professional shortage areas. This project will evaluate the effectiveness and mechanisms of mindfulness-based relapse prevention (MBRP) delivered via video conferencing, as compared to referral to online mutual support groups, in supporting long-term whole-person recovery and improvements in neurobiologically-informed domains of addiction among individuals with AUD who have recently made a change attempt to reduce or stop drinking. The project will also examine the reach, effectiveness, adoption, implementation, and maintenance of MBRP as an accessible and freely available continuing care option that supports long-term recovery from AUD in all communities nationwide, including medically underserved and health professional shortage areas.

PI_NAMEs: WITKIEWITZ, KATIE A (contact)

PROGRAM_OFFICER_NAME: HAGMAN, BRETT THOMAS

PROJECT_TERMS: Abstinence;addiction;Address;Adult;Affect;alcohol abuse therapy;alcohol and other drug;Alcohol consumption;alcohol use disorder;Alcoholics Anonymous;behavior change;Behavioral Mechanisms;behavioral response;Biochemical;Caring;chronic pain;Clinical;Communities;cost;craving;cue reactivity;Data;design;Disease remission;drinking;Drug usage;effectiveness evaluation;effectiveness testing;effectiveness/implementation design;Emotional;evidence base;executive function;experience;future implementation;Goals;Harm Reduction;Health;Health Benefit;health professional shortage areas;Health Services Accessibility;Heavy Drinking;improved;incentive salience;Individual;innovation;interest;Intervention;Life;long term recovery;Measures;medically underserved;Methods;mindfulness;Morbidity - disease rate;mortality;multi-site trial;National Institute on Alcohol Abuse and Alcoholism;negative affect;neuroadaptation;Neurobiology;opioid use disorder;Outcome;Participant;Personal Satisfaction;Persons;Pharmaceutical Preparations;pharmacologic;pilot trial;population based;Population Study;process evaluation;programs;prospective test;psychosocial;Public Health;Randomized;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recovery;relapse prevention;remote delivery;Reporting;response;Sampling;Self Efficacy;smoking relapse prevention;social health determinants;Support Groups;Testing;tool;translational study;underserved area;Videoconferencing;Work

PROJECT_TITLE: Mindfulness-Based Relapse Prevention as Video Conferencing Continuing Care to Promote Long Term Recovery from Alcohol Use Disorder

STUDY_SECTION_NAME: Clinical, Treatment and Health Services Research Study Section[AA-3]


NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Genetics

PI_NAMEs: CASCIOLA-ROSEN, LIVIA A (contact)

PROJECT_TERMS: ACE2;Applications Grants;Autoantibodies;autoimmune rheumatologic disease;Autoimmunity;Bar Codes;base;Base Sequence;biobank;Biological;Biological Assay;Biopsy;Budgets;career development;Cataloging;Cell Separation;Cells;Clinical;clinical center;clinical phenotype;cohort;Collaborations;Collection;Color;Communities;Complement Activation;Complex;Consultations;Coupled;Coupling;COVID-19 pandemic;Credentialing;Data Analyses;Deposition;Diagnosis;Disease;Distant;DNA;Endothelium;Environment;Enzyme-Linked Immunosorbent Assay;experience;Flow Cytometry;Funding;Generations;genetic pedigree;Genetic Variation;high dimensionality;Human;Human Biology;human disease;Immune;Immunoassay;Immunoglobulin M;Immunohistochemistry;Immunology procedure;In Vitro;Infrastructure;innovation;Institution;interest;Knowledge;Laboratories;Leadership;Measurement;member;Metabolic;Modality;Molecular;Monitor;mouse model;Pathogenicity;Pathway interactions;patient subsets;Patients;Peer Review;Peripheral Blood Mononuclear Cell;Phenotype;Plasma;Play;Population;Preparation;Prevention;Price;Process;Productivity;prospective;Publications;Quality Control;Rare Diseases;recruit;Research;Research Personnel;Resources;Retrieval;Rheumatism;Rheumatology;RNA;RNA library;Role;Running;Sampling;Scholarship;Serum;Services;severe COVID-19;single cell analysis;Site;Specimen;Standardization;Study models;Surveys;synergism;Temperature;Testing;Time;tool;Training;transcriptome sequencing;Validation;Whole Blood;Work

PROJECT_TITLE: Sample Processing and Immunoassay Research Core


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Mental Health;Mental Illness;Neurosciences;Precision Medicine;Prevention

PHR: PROJECT NARRATIVE Advances in the fields of neuroscience, genetics, and other biological fields are leading to profound transformations in our understanding of mental health. In order to translate this understanding into new and optimized treatment approaches, research training should encompass a solid foundation in translational science. Consistent with the Research Domain Criteria (RDoC) initiative and emerging work on the use of biomarkers to guide prediction of disease development and treatment response, our Translational Research Activities In Neuropsychiatry (TRAIN) program is designed to train the next generation of physician-scientists in psychiatry so that they can translate neuroscience and genetics research into better outcomes for individuals with mental illness.

PI_NAMEs: TRIVEDI, MADHUKAR H. (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: Adaptive Behaviors;addiction;Adoption;Area;base;Biological;Biological Markers;biomarker evaluation;burnout;career;Clinical;clinical care;Clinical Research;clinical training;Cognition;Communities;Coupled;Dedications;design;Detection;Development;Diagnosis;Disease;Doctor of Philosophy;Educational process of instructing;Electroencephalography;Epigenetic Process;Etiology;Faculty;Foundations;Functional disorder;Funding;Genetic;Genetic Research;Goals;graduate school;improved;Individual;Infrastructure;innovation;Knowledge;Leadership;leadership development;medical schools;Mental disorders;Mental Health;Mentors;National Institute of Mental Health;Neurobiology;neuroimaging;neuropsychiatry;Neurosciences;Neurosciences Research;next generation;novel;optimism;Outcome;personalized medicine;Physicians;Population;precision medicine;Precision therapeutics;prevent;Prevention;Process;Productivity;programs;promote resilience;prospective;Proteomics;Psychiatric therapeutic procedure;Psychiatry;Research;Research Activity;Research Domain Criteria;Research Personnel;Research Project Grants;Research Training;Residencies;Resources;Rural;Science;Scientist;Self Care;skill acquisition;skills;Solid;Structure;Target Populations;Techniques;Technology;Time;tool;Training;Training Programs;Translating;translational applications;Translational Research;translational scientist;Translations;treatment optimization;treatment response;Work;Youth

PROJECT_TITLE: Translational Research Activities in Neuropsychiatry (TRAIN) - Renewal - 1


NIH_SPENDING_CATS: Cancer;Clinical Research;Genetics;Hematology;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

PHR: Project Narrative PPM1D is recurrently mutated in clonal hematopoiesis and myeloid malignancies, resulting in elevated protein expression and chemotherapy resistance. This project seeks to define the role that PPM1D and PPM1D mutations play in hematopoiesis during steady state and under conditions of stress and to define the molecular mechanisms by which PPM1D is regulated by the proteasome.

PI_NAMEs: MILLER, PETER GRANT (contact)

PROGRAM_OFFICER_NAME: LIM, SUSAN E

PROJECT_TERMS: Address;Advisory Committees;Affect;Alleles;Amino Acids;Animals;Backcrossings;Binding;Biochemical;Biochemical Pathway;Biological;Biological Models;Biological Process;Biology;Biometry;Blood;C-terminal;career;career development;Cells;Chemoresistance;chemotherapy;Chemotherapy and/or radiation;Clinical;clinical practice;Collaborations;Communities;Complex;cytotoxic;Cytotoxic Chemotherapy;Dana-Farber Cancer Institute;Data;Development;Development Plans;Disease;DNA Damage;Educational process of instructing;Environment;experimental study;Exposure to;Genes;Genetic Screening;Goals;Hematologic Neoplasms;Hematology;Hematopoiesis;Hematopoietic;hematopoietic stem cell self-renewal;Hematopoietic stem cells;Human;human disease;Impairment;Individual;Inflammation;insight;International;Knock-in;Knock-in Mouse;Knock-out;Lead;leukemia;Malignant Neoplasms;MAP Kinase Gene;Maps;Mass Spectrum Analysis;mature animal;Mediating;Mentorship;Modeling;Molecular;mouse model;multicatalytic endopeptidase complex;Mus;mutant;Mutate;Mutation;Myeloproliferative disease;Neoplasms;novel;novel therapeutics;Oncologist;Oncology;overexpression;p38 Mitogen Activated Protein Kinase;Pathway interactions;Patient Care;Patients;Phenotype;Phosphoric Monoester Hydrolases;Physicians;Play;Poly I-C;Prevalence;protein degradation;Protein Dephosphorylation;protein expression;Protein phosphatase;Proteins;Proteomics;Radiation;Recurrence;Reporter;Research;Research Personnel;Resistance;response;Role;Scientist;self-renewal;Serine;stem cell biology;stem cell self renewal;Stress;System;Techniques;Testing;Therapeutic;therapeutic target;therapy development;Threonine;Time;TP53 gene;Training;Translational Research;Transplantation;tumorigenesis;Ubiquitin;ubiquitin ligase;ubiquitin-protein ligase;Ubiquitination;vector;Work

PROJECT_TITLE: Role of PPM1D and PPM1D mutations in hematopoiesis and response to stress

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Bioengineering;Data Science;Networking and Information Technology R&D (NITRD);Precision Medicine;Scleroderma

PI_NAMEs: ZEGER, SCOTT L. (contact)

PROJECT_TERMS: Address;Back;Bayesian Method;Center Core Grants;Clinical;Clinical assessments;clinical center;Clinical Data;clinical practice;Clinical Trials;clinically relevant;cloud based;cohort;Collaborations;collaborative environment;Communication;complex data;Computer software;Computerized Medical Record;Computing Methodologies;Data;Data Science;Data Science Core;Database Management Systems;Databases;design;Disease;disorder subtype;Event;experimental study;Foundations;Funding;Goals;Health;Healthcare Systems;Heterogeneity;implementation trial;improved;Individual;individual patient;Information Systems;Infrastructure;insight;Institution;Intervention;Laboratories;Learning;longitudinal dataset;Markov Chains;Measurement;Measures;Medicine;Methods;Modeling;Modernization;Myositis;novel;Observational Study;open source;optimal treatments;Outcome;patient subsets;Patients;Persons;Phase;Physics;Population;precision medicine;programs;Reproducibility;Research Design;Research Personnel;Resources;Rheumatism;Rheumatology;Science;Scleroderma;Secure;Statistical Data Interpretation;Statistical Methods;Subgroup;Techniques;tool;treatment choice;treatment effect;Treatment Efficacy;treatment response;Update;Visualization;Visualization software

PROJECT_TITLE: Data Science Core


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Neurosciences;Pediatric;Social Determinants of Health;Substance Misuse;Underage Drinking

ORG_CITY: BELMONT

ORG_NAME: MCLEAN HOSPITAL

PHR: PROJECT NARRATIVE The primary goals of this K24 renewal application are to enable Marisa M. Silveri, Ph.D., to continue to 1) provide substantive mentoring of junior investigators and trainees in POR (35%), with a focus on mentoring underrepresented minority trainees; 2) continue and extend involvement in my POR (10%), and 3) advance my expertise in the content areas of adolescent comorbid psychopathology, clinical approaches in adolescent treatment settings, and vulnerable populations, including gender and racial/ethnically diverse youth, for which there are significant mental health disparities (5%). The public health importance of this renewal application addresses the need to characterize neurobiological markers in addiction and psychiatric disorders, which will inform development of new and effective treatments for alcohol use disorder and for patients with dual diagnoses, and the need to train the next generation of investigators to develop the skills they require to effectively conduct research with patient populations.

PI_NAMEs: SILVERI, MARISA M (contact)

PROGRAM_OFFICER_NAME: GRAKALIC, IVANA

PROJECT_TERMS: addiction;Address;Adolescent;adolescent brain development;Adult;Alcohol abuse;Alcohol consumption;alcohol misuse;alcohol research;alcohol risk;alcohol use disorder;Alcohols;Ancillary Study;Anxiety;Anxiety Disorders;Applications Grants;Award;Big Data;Boston;Brain;career;career development;Child Abuse and Neglect;child depression;Child Traumatic Stress;childhood anxiety;Clinical;Clinical Research;Collaborations;Combined Modality Therapy;comorbidity;COVID-19 pandemic;Data;Data Analyses;depressive symptoms;Development;Development Plans;Diagnosis;Disadvantaged;Doctor of Philosophy;Education;effective therapy;emerging adult;Environment;ethnic disparity;ethnic diversity;experience;Exposure to;Faculty;Fostering;Foundations;Funding;Future;gender diverse;Gender Identity;Goals;Grant;Group Therapy;health disparity;Hospitals;Hour;Human;Individual;Inequality;inner city;Institution;Interdisciplinary Study;Intervention;Intervention Studies;Interview;Knowledge;Laboratories;lectures;life span;medical schools;meetings;Mental Depression;Mental disorders;Mental Health;Mentored Clinical Scientist Development Program;Mentors;Mentorship;Mid-Career Clinical Scientist Award (K24);mid-career faculty;minority children;Minority Groups;minority trainee;Monitor;Mood Disorders;National Institute of Drug Abuse;National Institute of Mental Health;National Institute on Alcohol Abuse and Alcoholism;Neurobiology;Neurocognitive;neurodevelopment;neuroimaging;Neurosciences Research;next generation;outreach;Paper;patient oriented;patient oriented research;patient population;Patients;Peer Review;Peer Review Grants;Peptides;Population;Population Study;pre-clinical;Preparation;Prevention;Principal Investigator;programs;Psychiatry;Psychopathology;Public Health;Publications;Publishing;Race;racial diversity;Recovery;Regimen;Research;Research Personnel;Residencies;Resources;Risk;Role;Scholars Program;Sexual and Gender Minorities;Site;skills;stem;Stress;substance use;success;Time;Training;transgender;underage drinking;undergraduate student;Underrepresented Minority;United States National Institutes of Health;vulnerable adolescent;Vulnerable Populations;Women's Health;Work;Yoga;Youth

PROJECT_TITLE: Mentoring in Patient-Oriented Neuroscience Research

STUDY_SECTION_NAME: Neuroscience and Behavior Study Section[AA-4]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Digestive Diseases;Microbiome;Nutrition;Substance Misuse

ORG_CITY: CLEVELAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

PHR: PROJECT NARRATIVE Alcohol use disorder, a leading cause of morbidity and mortality worldwide, is associated with gut dysbiosis, intestinal permeability and increased endotoxin into circulation, which induces inflammatory responses that drive organ injury, but the target and driver of ethanol-induced inflammation is uncertain. We recently showed the gut fermentation byproduct butyrate is protective against ethanol-induced gut permeability and associated liver inflammation and injury, and that this protection was linked with preserved markers for intestinal endothelium and reduced oxidative stress in mice. Here we will determine the mechanisms for protective effects of immune nutrients, butyrate and all trans retinoic acid, in intestinal microvascular endothelium and T-lymphocytes, with the long-term goal of this project aimed at identifying therapeutic agents that will protect against ethanol-induced injury to intestine and subsequently other organs.

PI_NAMEs: CRESCI, GAIL ANN (contact)

PROGRAM_OFFICER_NAME: WANG, JOE

PROJECT_TERMS: Acetates;Acute;Adolescent;Adult;Affect;Alcohol consumption;alcohol effect;alcohol exposure;alcohol testing;alcohol use disorder;Alcohol-Induced Disorders;Alcohols;Animal Model;Autoimmune Diseases;Biological;Blood Vessels;Brain;Butyrates;Cells;Chronic;Circulation;Coculture Techniques;Colon;Consumption;cost;cytokine;Development;Diffuse;driving force;Endothelium;Endotoxins;Epithelium;Ethanol;feeding;Fermentation;Functional disorder;gastrointestinal epithelium;Gene Expression Regulation;Goals;gut dysbiosis;gut microbiome;Healthcare;Heart;Heavy Drinking;Hepatic;Homeostasis;Homing;Human;Immune;immune activation;immune function;Immune response;Immune system;Immunity;Impairment;improved;in vivo;Inflammation;Inflammatory;Inflammatory Response;insight;Intercellular Junctions;Interleukin-10;intestinal epithelium;intestinal homeostasis;intestinal injury;Intestinal permeability;Intestines;Invaded;Laboratories;Lamina Propria;Leukocytes;Link;Lipopolysaccharides;Liver;liver inflammation;liver injury;Lung;macromolecule;Macrophage;Malignant Neoplasms;Mediating;Microbe;microbial;Microvascular Permeability;Morbidity - disease rate;mortality;mouse model;Mucositis;Mucous Membrane;Mus;Muscle;novel;novel therapeutics;Nutrient;nutrient metabolism;Oral;Organ;organ growth;organ injury;Oxidative Stress;Pancreas;pathogenic bacteria;Pathology;Perfusion;Play;Population;Portal vein structure;preservation;prevent;preventable death;Prevention;Prodrugs;Productivity;Propionates;protective effect;Proteins;recruit;Regulation;Regulatory T-Lymphocyte;Reporting;response;Role;Splenocyte;STAT3 gene;Supplementation;System;T cell response;T-Cell Homing Receptors;T-Lymphocyte;Testing;Therapeutic;Therapeutic Agents;Tight Junctions;TLR4 gene;transcription factor;transcriptome sequencing;Tretinoin;tributyrin;United States;Vascular Endothelial Cell;Vascular Endothelium;Virus Diseases;Volatile Fatty Acids

PROJECT_TITLE: Alcohol and intestinal microvascular endothelium-immune axis and the role of gut derived immune nutrients

STUDY_SECTION: XNDA

STUDY_SECTION_NAME: Xenobiotic and Nutrient Disposition and Action Study Section[XNDA]


NIH_SPENDING_CATS: Cardiovascular;Congenital Heart Disease;Genetics;Heart Disease;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: COLUMBIA

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

ORG_STATE: SC

PHR: Public Health Relevance (Narrative Statement) Ryanodine receptors (RyR2) mediate the release of Ca2+ for cardiac contraction and its dysfunctions underlie many cardiac pathologies, including heart failure and arrhythmia. Mechanistic data on the pathologies of RyR2 have come from transgenic mouse or heterologous cell models, with low relevance to human heart. Here we propose to develop powerful molecular and imaging tools to investigate the RyR2 disease-associated mutations in human stem cell derived cardiomyocytes, and believe that our unique multi-disciplinary approach will enhance the understanding of molecular regulatory sites of this protein and its pathologies.

PI_NAMEs: MORAD, MARTIN  (contact);YAMAGUCHI, NAOHIRO

PROGRAM_OFFICER_NAME: BALIJEPALLI, RAVI C

PROJECT_TERMS: Adrenergic Agents;Adrenergic beta-Agonists;Adult;Affinity;alpha helix;Amino Acids;Arrhythmia;Back;Binding;Binding Sites;Biochemical;Biological Assay;Caffeine;Cardiac;Cardiac Myocytes;Cardiomyopathies;Catecholaminergic Polymorphic Ventricular Tachycardia;Cell model;Cells;Classification;Complement;Computer Simulation;confocal imaging;Coupling;CRISPR/Cas technology;Data;Disease;Dissociation;Electrophysiology (science);Exhibits;FKBP1B gene;Functional disorder;Genes;Genetic;Heart;Heart failure;Heart Hypertrophy;Human;Human Engineering;human induced pluripotent stem cells;human stem cell-derived;Imaging Device;Impairment;in vivo;induced pluripotent stem cell derived cardiomyocytes;insight;interdisciplinary approach;Knock-in;Link;loss of function;loss of function mutation;Maps;Mediating;Membrane;Missense Mutation;Modeling;Molecular;mouse model;Mus;Muscle Cells;Mutagenesis;mutant;Mutate;Mutation;Myocardial dysfunction;Myocardium;novel;novel strategies;patch clamp;Pathology;Pharmaceutical Preparations;pharmacologic;Phenotype;Phosphoric Monoester Hydrolases;Phosphotransferases;Protein Kinase;Proteins;public health relevance;Recombinants;Regulation;Research;Resolution;response;Ryanodine;Ryanodine Receptor Calcium Release Channel;RyR1;Sarcoplasmic Reticulum;Signal Pathway;Signal Transduction;Site;skeletal;Specificity;Structural Models;Structure;System;Tacrolimus Binding Proteins;Tail;Testing;Total Internal Reflection Fluorescent;Transgenic Mice

PROJECT_TITLE: Functional implications of CPVT1-associated RyR2 mutations in human cardiomyocytes

STUDY_SECTION: MPPA

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology A Study Section [MPPA]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Emergency Care;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Networking and Information Technology R&D (NITRD);Patient Safety;Pediatric;Prevention;Rural Health;Telehealth

ORG_CITY: BOSTON

ORG_NAME: BOSTON MEDICAL CENTER

PHR: PROJECT NARRATIVE Our objective is to determine if video-conferencing with pediatric experts using mobile devices (teleconsultation) can improve emergency care for sick and injured children in ambulances. With emergency service personnel, we will: (1) optimize a video-conferencing platform for efficient and easy use outside the hospital; (2) determine whether they would and could use this technology, and if it makes care safer using infant patient simulators; and (3) determine if pediatric expert physicians in hospitals can use this technology to assess children in ambulances before they arrive at the hospital. This work has the potential to improve access to high quality emergency care for children, especially in rural and underserved communities.

PI_NAMEs: BOYLE, TEHNAZ PARAKH (contact)

PROGRAM_OFFICER_NAME: WOO, SEUNG KYOON

PROJECT_TERMS: acceptability and feasibility;Acute;acute care;Adoption;Adult;Adverse event;Ambulances;Applied Skills;arm;Assessment tool;Award;Basic Science;Blinded;Board Certification;Boston;care systems;career;career development;Caring;Child;Child Care;child services;Childhood;Childhood Injury;Clinical;clinical effect;clinical practice;Clinical Trials Design;Communities;community partnership;Critical Illness;Data;design;Development Plans;Early Intervention;Education;Educational Intervention;Educational workshop;Effectiveness;efficacy trial;Emergency Care;Emergency Department Physician;Emergency medical service;Emergency research;emergency service responder;Emergency Situation;Equipment;Ethics;Event;Evidence based intervention;experience;field study;Focus Groups;Funding;Future;Goals;Grant;handheld mobile device;Heart Diseases;hospital care;Hospitals;Human;human subject;Human Subject Research;Improve Access;improved;improved outcome;Individual;Infant;Informed Consent;Infrastructure;innovation;Internships;Intervention;Intervention Trial;Interview;Knowledge;Life;Massachusetts;Measurable;Measures;medical specialties;meetings;Mentors;Methods;Modeling;models and simulation;multidisciplinary;novel;open label;Outcome;Paramedical Personnel;Participant;patient oriented research;patient safety;Patient-Focused Outcomes;Patients;pediatric emergency;Pediatric Hospitals;Pediatrics;Performance;Pharmaceutical Preparations;Phase;Physicians;pilot test;Positioning Attribute;practice setting;pre-clinical;Pre-hospital setting;Pre-hospitalization care;Predisposition;Prehospital Emergency Care;primary outcome;Procedures;Process;professor;programs;Protocols documentation;Provider;Quality of Care;Questionnaires;Radio;Randomized;Randomized, Controlled Trials;Readiness;recruit;Regulation;remote assessment;Reporting;Research;Research Ethics;Research Personnel;Research Priority;research study;Research Training;respiratory;Respiratory distress;Respiratory Failure;Resuscitation;risk minimization;Rural;Rural Community;Safety;Sample Size;Scientist;secondary outcome;service providers;severe injury;simulation;skills;Specialist;Stroke;Structure;success;Surveys;System;Technology;teleconsultation;telehealth;Telemedicine;Testing;theories;Time;tool;Training;Training Programs;treatment arm;treatment as usual;Treatment Efficacy;underserved community;Universities;usability;Videoconferencing;Work;Workload

PROJECT_TITLE: Improving Prehospital Pediatric Emergency Readiness with Telemedicine


ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE The mission of the Waisman Center IDDRC at the University of Wisconsin-Madison is to promote the highest level of IDD research by providing access to cutting-edge and cost-effective core services, seminars, and pre- and post-doctoral training, via a comprehensive program designed to produce a transformative understanding of IDD pathology, development of new interventions, and training the next generation of basic and clinical IDD researchers.

PI_NAMEs: CHANG, QIANG  (contact)

PROGRAM_OFFICER_NAME: KAU, ALICE S

PROJECT_TERMS: Address;Agriculture;Animals;Attention deficit hyperactivity disorder;autism spectrum disorder;autistic children;Award;Behavior Therapy;Behavioral;behavioral phenotyping;biobehavior;Bioinformatics;Biological;Biological Response Modifier Therapy;Biological Sciences;Biometry;Brain imaging;Child;Clinical;Clinical assessments;Clinical Research;clinical translation;Clinical Trials;Cognitive;collaborative approach;college;Communities;community clinic;Consultations;cost effective;design;Development;Diagnostic Services;Ecology;Education;Educational workshop;Electroencephalography;Engineering;Environment;experience;Exposure to;Faculty;Family;Fellowship;Fostering;functional near infrared spectroscopy;Funding;Generations;Genetic Engineering;Genomics;Home;Human;Human Cell Line;human pluripotent stem cell;Imaging Device;improved;Individual;innovation;Institution;instrumentation;Intellectual and Developmental Disabilities Research Centers;Intellectual functioning disability;interdisciplinary approach;interdisciplinary collaboration;Intervention;Investigation;Joints;K-Series Research Career Programs;Knowledge;Laboratories;Language Disorders;leadership development;Letters;Liquid substance;Machine Learning;Magnetic Resonance Imaging;medical schools;meetings;Mentors;method development;Methods;microPET;Mission;Modeling;Molecular;Mouse Strains;mutant;National Institute of Child Health and Human Development;Nervous System Disorder;neurobehavioral;neurodevelopment;neuroimaging;Neurosciences;next generation;nonhuman primate;Nursery Schools;Participant;Pathology;Positron-Emission Tomography;post-doctoral training;pre-doctoral;Prevention;Privatization;Production;Productivity;Program Development;programs;Public Health;Quality of life;Rattus;recruit;Request for Applications;Research;Research Personnel;Research Project Grants;Resources;Rodent;Scanning;Schools;Science;Scientific Advances and Accomplishments;Scientist;Seasons;Series;Services;Social Work;special interest group;stem cells;Sum;Symptoms;System;Teacher Professional Development;Techniques;Time;Training;training opportunity;Training Programs;Translational Research;translational research program;treatment services;undergraduate student;United States National Institutes of Health;Universities;Veterinary Medicine;Wisconsin

PROJECT_TITLE: Waisman Center Intellectual and Developmental Disabilities Research Center