NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Rural Health;Social Determinants of Health

ORG_CITY: DECATUR

ORG_NAME: DECATUR MEMORIAL HOSPITAL

PHR: The Heartland Cancer Research NCORP (Heartland NCORP) will be the premier community cancer research organization of the states of Illinois and Missouri by providing state of the art cancer clinical trials, cancer care delivery research, interdisciplinary cancer treatment planning, and coordinated biomarker driven research throughout our service region. Cancer patients, in specific, will benefit as a direct result of these clinical trials, and the consequential knowledge on preventing and treating malignancy in community settings will improve patient care.

PI_NAMEs: FALLER, BRYAN  (contact)

PROGRAM_OFFICER_NAME: WHITE, VANESSA

PROJECT_TERMS: anti-cancer research;base;biobank;biomarker driven;cancer care;cancer clinical trial;cancer education;Cancer Patient;cancer prevention;cancer therapy;care delivery;Caring;Clinical Research;Clinical Trials;Communities;community setting;Early Diagnosis;Education;Feedback;Health Personnel;Health Professional;high standard;Illinois;Improve Access;improved;Knowledge;Malignant Neoplasms;Missouri;multidisciplinary;Patient Care;Patients;Pilot Projects;prevent;Productivity;recruit;Research;Research Personnel;Resource-limited setting;Resources;Rural;Rural Population;screening;Services;survivorship;Tissues;Training;treatment planning;treatment trial;Underserved Population;Urban Population;vector;Vision;Vulnerable Populations

PROJECT_TITLE: Heartland Cancer Research NCORP


ADMINISTERING_IC: CA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;HIV/AIDS;Hematology;Hodgkin's Disease;Human Genome;Infectious Diseases;Lymphatic Research;Lymphoma;Rare Diseases

ORG_CITY: NEW YORK

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PATHOLOGY

ORG_FIPS: US

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: Narrative People living with HIV are at a much higher risk for developing B cell lymphomas, and these are frequently caused by the Epstein Barr virus. This grant investigates how the biology of B cells determines what viral proteins are expressed, how the virus affects B cell biology, and how these events lead to lymphoma development.

PI_NAMEs: CESARMAN, ETHEL  (contact);GEWURZ, BENJAMIN ELISON;ROTH, LISA GIULINO

PROGRAM_OFFICER_NAME: READ-CONNOLE, ELIZABETH LEE

PROJECT_TERMS: 3-Dimensional;Acquired Immunodeficiency Syndrome;Address;Affect;AIDS-Related Diffuse Large B-cell Lymphoma;AIDS-Related Lymphoma;antiretroviral therapy;B cell differentiation;B lymphocyte immortalization;B-Cell Development;B-Cell Lymphomas;B-Lymphocytes;BCL6 gene;Biology;Burkitt Lymphoma;cancer genome;cDNA Expression;Cell Compartmentation;Cells;Cellular biology;Central Nervous System Lymphoma;chemical genetics;ChIP-seq;Chromatin;Classification;Clustered Regularly Interspaced Short Palindromic Repeats;co-infection;cohort;Cues;cytokine;Cytometry;Cytosine;derepression;Development;DNA;DNA Modification Methylases;DNMT3B gene;Down-Regulation;driver mutation;Enzymes;Epigenetic Process;epigenome;Epstein Barr Virus B cell lymphoma;Epstein-Barr Virus Infections;Epstein-Barr Virus latency;Epstein-Barr Virus-Related Lymphoma;Epstein-Barr Virus-Related Malignant Neoplasm;Event;Exhibits;Family;Foundations;Frequencies;Future;Gene Silencing;Genes;Genetic;genetic analysis;genetic manipulation;Genetic Transcription;Genome;Grant;Herpesviridae;Heterogeneity;high risk;Histologic;Histone H1;histone methyltransferase;Histones;HIV;Hodgkin Disease;Human;Human Herpesvirus 4;Image;Immune;Immunocompetent;Immunologics;infected B cell;Infection;Integration Host Factors;interleukin-21;Intrinsic factor;Knowledge;large cell Diffuse non-Hodgkin's lymphoma;Large-Cell Immunoblastic Lymphoma;latent gene expression;Lead;Learning;Link;LMP1;loss of function mutation;Lymphoma;Lymphomagenesis;Lymphoproliferative Disorders;lytic gene expression;Maintenance;Malignant - descriptor;Malignant Neoplasms;Mediating;Memory;Methylation;Methyltransferase;Mexico;Modeling;Molecular;multiple omics;Mutate;Mutation;Mutation Analysis;neoplastic cell;novel therapeutic intervention;Oncogenic;Oncogenic Viruses;Oncoproteins;Patients;Pattern;Persons;post-transplant;PRC1 Protein;pressure;primary effusion lymphoma;programs;promoter;Protein Isoforms;Proteomics;recruit;Recurrence;Regulation;Role;Sampling;Signal Transduction;Site;STAT3 gene;Structure of germinal center of lymph node;superinfection;T-Cell Immunodeficiency;tumor;Tumor-Derived;Ubiquitination;Untranslated RNA;Variant;Viral;viral DNA;Viral Genome;viral genomics;Viral Proteins;virology;Virus;Virus Latency;Work

PROJECT_TITLE: B cell determinants of EBV latency


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Data Science;Kidney Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Precision Medicine;Prevention

ORG_CITY: CHICAGO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Up to 20% of hospitalized patients develop acute kidney injury, which is associated with increased risk of readmission, morbidity, and mortality. This project will use advanced machine learning methods and biomarkers to improve the identification and treatment of patients at risk of acute kidney injury. This project will result in novel tools and personalized treatment algorithms that can be implemented to improve patient outcomes.

PI_NAMEs: CHURPEK, MATTHEW MICHAEL;KOYNER, JAY L (contact)

PROGRAM_OFFICER_NAME: SCHULMAN, IVONNE HERNANDEZ

PROJECT_TERMS: Acute Renal Failure with Renal Papillary Necrosis;Admission activity;Albuminuria;Algorithms;Biological Markers;Blood Urea Nitrogen;Caring;Clinical;clinical practice;Code;cohort;comorbidity;Consensus;Consult;cost;cost estimate;Creatinine;Data;deep learning;deep learning algorithm;deep learning model;deep neural network;Detection;detection method;Development;diagnosis standard;Discrimination;Early Diagnosis;Early Intervention;Electronic Health Record;electronic structure;Electronics;forest;Future;Gold;Growth;Guidelines;Health system;Healthcare Systems;high risk;hospital readmission;Hospitalization;Hospitals;Hour;Hypotension;improved;improved outcome;Incidence;Injury;Injury to Kidney;Inpatients;Intervention;Kidney;Knowledge;LCN2 gene;Length of Stay;Machine Learning;machine learning algorithm;machine learning method;Manuals;Measures;Methods;Modeling;Morbidity - disease rate;mortality;Multi-Institutional Clinical Trial;Natural Language Processing;Nephrology;nephrotoxicity;Neural Network Simulation;novel;novel marker;Outcome;Output;participant enrollment;Pathway interactions;Patient Care;Patient-Focused Outcomes;Patients;personalized care;personalized medicine;Pharmaceutical Preparations;Phenotype;predictive marker;Predictive Value;Prevalence;readmission risk;Recommendation;Research;Risk;Risk Assessment;Risk Factors;risk prediction model;risk stratification;Running;Serum;success;Syndrome;Text;Time;TIMP2 gene;tool;Tubular formation;United States;urinary;Urine;Work

PROJECT_TITLE: Using Machine Learning for Early Recognition and Personalized Treatment of Acute Kidney Injury

STUDY_SECTION: CIDH

STUDY_SECTION_NAME: Clinical Informatics and Digital Health Study Section[CIDH]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Mental Health;Mental Illness;Neurosciences;Pediatric;Post-Traumatic Stress Disorder (PTSD)

ORG_CITY: BELMONT

ORG_NAME: MCLEAN HOSPITAL

ORG_STATE: MA

PHR: Individuals with a history of interpersonal trauma exposure are at risk for progressive social withdrawal during the transition to adulthood (ages 16-20), and although social withdrawal is strongly associated with detrimental health outcomes, neurobiological processes that contribute to social withdrawal following trauma exposure have not been identified. In line with NIMH Objective 2.2 (Identify and understand risk factors, biomarkers, and behavioral indicators of mental illnesses and of intervention responses across the lifespan), in the short term this study will: (1) identify how connectivity within a specified neural circuit is associated with baseline social withdrawal as well as change in social withdrawal over time, and (2) develop predictive algorithms that can forecast future social withdrawal based on baseline connectivity within the circuit. In the long term, understanding how connectivity within this circuit contributes to progressive social withdrawal may contribute to the development of interventions that target this circuit (e.g. neurofeedback) and may shift the field toward emphasizing the role of reward processing abnormalities in contributing to social withdrawal in trauma-exposed individuals.

PI_NAMEs: ROSSO, ISABELLE M (contact)

PROGRAM_OFFICER_NAME: BORJA, SUSAN EILEEN

PROJECT_TERMS: 20 year old;Accelerometer;Adolescent;Adolescent and Young Adult;Age;Alcohol consumption;Amygdaloid structure;Anhedonia;Automobile Driving;Behavioral;Biological Markers;Brain region;cardiovascular risk factor;Categories;Cellular Phone;Characteristics;Clinical;Code;Data;Data Collection;density;depressive symptoms;Development;Diagnostic;digital phenotyping;disability;Ecological momentary assessment;Emotions;Enrollment;Evolution;Exposure to;Extinction;Face;follow-up;Frequencies;Fright;Functional Magnetic Resonance Imaging;functional MRI scan;Future;Health;Human;Immune response;Impairment;Incentives;Individual;innovation;interpersonal trauma;Intervention;Interview;learning strategy;life span;Literature;Location;Loneliness;longitudinal design;Machine Learning;Major Depressive Disorder;Measures;Mental disorders;Mental Health;Metadata;Modeling;mortality;National Institute of Mental Health;neural circuit;neurobiological mechanism;Neurobiology;neurofeedback;neuroimaging;Nucleus Accumbens;Outcome;Participant;Pathologic;Patient Self-Report;Phenotype;physical conditioning;Population;Post-Traumatic Stress Disorders;post-traumatic symptoms;prediction algorithm;predictive modeling;Prefrontal Cortex;Process;prospective;Psychopathology;rapid growth;Recording of previous events;Research;response;Rest;reward circuitry;reward processing;Rewards;Risk;Risk Factors;Role;Sampling;social;social anxiety;Social Behavior;social engagement;Social Interaction;Social Network;Specific qualifier value;Structure;substance use;suicidal risk;Text;therapy development;Time;transition to adulthood;Trauma;trauma exposure;Well in self;Withdrawal;Work

PROJECT_TITLE: Progressive social withdrawal in trauma-exposed older adolescents and young adults: neurocircuitry predictors

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


ADMINISTERING_IC: AI

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Bioengineering;Biotechnology;Clinical Research;Emerging Infectious Diseases;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Lung;Pediatric;Social Determinants of Health

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE The management of pediatric acute respiratory illness (ARI) in resource-constrained settings in sub-Saharan Africa is almost entirely based on clinical symptoms, the non-specific nature of which contributes to both over- and under-treatment with antibiotics. Measuring host immune response gene expression can differentiate between viral and bacterial ARI, but the validation of classifiers based on this methodology has included very little data from sub-Saharan Africa where the burden of ARI is high and co-morbidities that may affect the immune response like malaria and malnutrition are more common. This study seeks to develop and internally validate novel clinical algorithms for pediatric ARI that leverage existing host immune response classifiers for ARI after optimization for use in resource-constrained settings.

PI_NAMEs: CICCONE, EMILY JANE (contact)

PROGRAM_OFFICER_NAME: BROWN, LILIANA L

PROJECT_TERMS: Acceleration;acceptability and feasibility;Acute;Acute respiratory infection;adjudication;Affect;Africa South of the Sahara;Age;Algorithms;Antibiotic Therapy;Antibiotics;antimicrobial;Antimicrobial Resistance;Applications Grants;Bacterial Infections;Biological Markers;Biometry;Biostatistical Methods;Blood;Blood specimen;C-reactive protein;Categories;Child;Childhood;Clinical;clinical biomarkers;clinical predictive model;co-infection;cohort;Cohort Studies;communicable disease diagnosis;comorbidity;Data;Derivation procedure;design;Detection;Development;Diagnosis;Diagnostic;diagnostic development;Diagnostic tests;diagnostic tool;differential expression;disease diagnostic;Enrollment;Etiology;Evaluation;evaluation/testing;experience;Fever;Gene Expression;Gene Expression Profile;Gene Expression Profiling;Genes;global health;Goals;Growth;Hospitalization;Immune response;Immune Response Genes;improved;Infection;influenza pneumonia;Knowledge;Laboratories;Malaria;Malnutrition;Measurement;Measures;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Metagenomics;Methodology;Modeling;Molecular;Molecular Profiling;Nasopharynx;Nature;next generation sequencing;North Carolina;novel;novel diagnostics;Participant;pathogen;pediatrician;Performance;performance tests;Physicians;point of care;Polymerase Chain Reaction;Population;Positioning Attribute;predictive modeling;Probability;procalcitonin;Process;prospective;Quality of Care;Reference Standards;Research Personnel;Resource-limited setting;respiratory;Respiratory Signs and Symptoms;Role;Sampling;Scientist;Seasons;Site;Streptococcus pneumoniae;Symptoms;Syndrome;Technology;Test Result;Testing;Time;tool;Training;training opportunity;Transcript;Uganda;Uncertainty;Universities;Validation;Viral;Virus;Virus Diseases;Work

PROJECT_TITLE: Leveraging Molecular Technologies to Improve Diagnosis and Management of Pediatric Acute Respiratory Illness in Resource-Constrained Settings

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases B Research Study Section[MID-B]


ADMINISTERING_IC: ES

FUNDING_MECHANISM: OTHERS

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

ORG_CITY: Cincinnati

ORG_NAME: INTERNATIONAL CHEMICAL WORKERS UNION

ORG_STATE: OH

PHR: The ICWU, with the IAMAW, will continue to develop DOE worker trainers (on site recognized experts) at four facilities using adult education principles to teach key principles in a non-threatening and engaging method that motivates participants to become active in improving their worksites.

PI_NAMEs: GLINES-ALLEN, SHARI LYNN (contact)

PROGRAM_OFFICER_NAME: BEARD, SHARON

PROJECT_TERMS: Adult;African American;Area;Baptist Church;Categories;Chemicals;Cities;Collaborations;Community Outreach;Complex;Confined Spaces;Contractor;cost effective;course development;Development;Educational Curriculum;Educational Models;Educational process of instructing;Educational Technics;Educational Technology;Employee;Equipment;Evaluation;experience;falls;fire fighter;First Aid;Hazardous Waste Operations and Emergency Response;Health;Hour;Human Resources;improved;Indian reservation;International;Joints;Kansas;Knowledge;Laboratories;Maps;Marketing;meetings;member;Methods;Midwestern United States;minority communities;National Institute of Environmental Health Sciences;Nuclear Weapon;outreach;Participant;Procedures;programs;Protective Clothing;Publications;Quality Control;Resources;Respirators;Safety;Site;success;Toxic effect;Training;Training Technics;Tribes;Umatilla;Universities;Vocational Education;Wages;Washington;Work;Workplace

PROJECT_TITLE: Hazmat Training at DOE Nuclear Weapons Complex


ORG_CITY: HANOVER

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: Project Narrative  Serotonin and acetylcholine are two “modulatory” neurotransmitters that are critical for normal cognitive function, and disruption of these modulatory signaling systems in the cerebral cortex contributes to a broad spectrum of psychiatric diseases. The proposed research contributes to public health and the core mission of the NIMH by elucidating, at the cellular and microcircuit levels, how these two modulators reciprocally regulate cortical output to cortical and subcortical targets.

PI_NAMEs: GULLEDGE, ALLAN T (contact)

PROGRAM_OFFICER_NAME: NADLER, LAURIE SUE

PROJECT_TERMS: Acetylcholine;Action Potentials;Advanced Development;Area;Automobile Driving;Axon;Behavior;Brain Stem;Cells;Cerebral cortex;Choline;cholinergic;clinically relevant;Cognition;cognitive function;cognitive task;Communication;Contralateral;Corpus striatum structure;Data;Distant;Etiology;excitatory neuron;Excitatory Synapse;Exhibits;G-Protein-Coupled Receptors;Generations;Glutamates;hippocampal pyramidal neuron;Hippocampus;Impaired cognition;innovation;insight;Maps;Measures;Medial;Medial Dorsal Nucleus;Mental disorders;Mission;Mus;National Institute of Mental Health;Neocortex;neural circuit;neuronal circuitry;neuronal excitability;Neurons;neuropsychiatric disorder;neuroregulation;Neurotransmitters;novel therapeutic intervention;Optics;optogenetics;Output;Patients;Pattern;Performance;Physiological;Pilot Projects;postsynaptic;postsynaptic neurons;Prefrontal Cortex;presynaptic;Public Health;Pyramidal Tracts;Regulation;Reporting;Research;Research Proposals;Reuniens Thalamic Nucleus;segregation;serotonergic regulation;Serotonin;Signal Transduction;Source;Synapses;System;Testing;Thalamic structure;Viral;Whole-Cell Recordings

PROJECT_TITLE: Coordinated modulation of cortical circuits by serotonin and acetylcholine

STUDY_SECTION: MNPS

STUDY_SECTION_NAME: Molecular Neuropharmacology and Signaling Study Section[MNPS]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Mental Health;Neurodegenerative;Neurosciences

ORG_CITY: AUGUSTA

ORG_DEPT: NEUROSCIENCES

ORG_NAME: AUGUSTA UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Alzheimer’s disease (AD) is the most common neurodegenerative disorder, currently accounting for 60–80 % of dementia cases. This application aims at identifying the mechanisms underlying stress-accelerated aging and AD progression.

PI_NAMEs: LU, XIN-YUN  (contact)

PROGRAM_OFFICER_NAME: GRAY, ERIN EMILY

PROJECT_TERMS: abeta accumulation;abeta deposition;Abeta synthesis;Acceleration;Accounting;Age;age acceleration;age related;age related neurodegeneration;Aging;aging brain;aging related;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease patient;Amyloid beta-Protein;Behavior;Behavioral;biological adaptation to stress;Brain;Brain region;Cells;Chronic;Chronic stress;Cognitive;Corticotropin-Releasing Hormone;Data;Deacetylase;Dementia;Disease Progression;Down-Regulation;Exposure to;Feedback;gamma-Aminobutyric Acid;Glucocorticoid Receptor;Glucocorticoids;Goals;Hydrocortisone;Hyperactivity;hyperphosphorylated tau;Hypothalamic structure;hypothalamic-pituitary-adrenal axis;Impaired cognition;interest;Knock-in Mouse;Memory impairment;Memory Loss;Molecular;Molecular Target;Mus;neural;Neurodegenerative Disorders;Neuronal Dysfunction;Neurons;neuropathology;novel;old mice;overexpression;paraventricular nucleus;Pathogenesis;Pathology;Phenotype;Population;Potassium;Predisposition;Production;Regulation;Research;Resistance;response;restraint stress;Risk Factors;Role;Senile Plaques;SIRT1 gene;social;Stress;Structure of nucleus infundibularis hypothalami;tau Proteins;Testing;transcriptome

PROJECT_TITLE: Role of AgRP neurons in chronic stress-accelerated brain aging and progression of Alzheimer's disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AN-Q(55)M]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Contraception/Reproduction;Dementia;Estrogen;Genetics;Menopause;Neurodegenerative;Neurosciences;Osteoporosis;Women's Health Research

ORG_DEPT: PHARMACOLOGY

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: PROJECT NARRATIVE  Women suffer more frequently with Alzheimer's disease than men, and have a more rapid onset and greater symptom burden. We have identified the pituitary hormone FSH, the blood levels of which rise after menopause, as a potential contributor to AD in aging women. In this proposal, we propose to utilize human brain tissue, cultured human neurons, and mouse models of AD to understand the mechanism of FSH action on brain, and determine whether one can prevent or reverse cognitive decline by reducing FSH levels––a prelude to a future FSH–based therapeutic for AD.

PI_NAMEs: HAROUTUNIAN, VAHRAM ;YUEN, TONY ;ZAIDI, MONE  (contact)

PROGRAM_OFFICER_NAME: CHAKROBORTY, SHREAYA

PROJECT_TERMS: 3xTg-AD mouse;abeta accumulation;Affect;aged;Aging;Alzheimer like pathology;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease therapeutic;Amyloid beta-Protein Precursor;Antibodies;Antibody-mediated protection;Architecture;Area;Asparagine;Automobile Driving;Blocking Antibodies;Blood;Body fat;bone;bone loss;Brain;Brain region;brain tissue;Bypass;Cells;Cholesterol;Clinical;Cognitive;cognitive function;Coupled;Data;Dementia;design;Discipline;Disease;disease phenotype;Disparate;Endocrinology;Endopeptidases;energy balance;Energy Metabolism;Estrogen decline;Estrogen Replacements;Estrogens;Evaluation;Evolution;Fatty acid glycerol esters;Female;Follicle Stimulating Hormone;Follicle Stimulating Hormone Receptor;Future;Genetic study;Goals;Gonadal structure;good laboratory practice;Health Hazards;Hippocampus;Histocytochemistry;hormonal signals;Hormones;Human;hypercholesterolemia;Impaired cognition;Injections;interdisciplinary collaboration;knock-down;Knock-in Mouse;laser capture microdissection;Life;life span;loss of function;male;Maps;Medical;men;Menopause;mild cognitive impairment;mouse model;Mus;Nature;Neurofibrillary Tangles;Neurons;Neurosciences;Obesity;Organ;Osteoporosis;Ovariectomy;overexpression;Pathogenesis;Pathway interactions;Perimenopause;Phase;Phenotype;Physiology;Pituitary Hormones;polyclonal antibody;Postmenopause;prevent;Proto-Oncogene Proteins c-akt;Public Health;receptor expression;Recombinant Follicle Stimulating Hormone;Rodent;Role;secretase;Senile Plaques;Serum;Sex Differences;Signal Transduction;small hairpin RNA;Small Interfering RNA;Specific qualifier value;Symptom Burden;tau Proteins;Technology;Testing;Textbooks;Thyroid Gland;Thyrotropin;Transcript;transcriptome sequencing;transcriptomics;Treatment Protocols;Up-Regulation;Woman;women versus men

PROJECT_TITLE: Elevated FSH - A Driver for Sex Differences in Alzheimer's Disease


ADMINISTERING_IC: GM

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Data Science;Pediatric;Rural Health;Social Determinants of Health

ORG_CITY: MEMPHIS

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF TENNESSEE HEALTH SCI CTR

ORG_STATE: TN

PHR: Our long-term goal is to improve knowledge and education in clinical laboratory science and public health information technology professions through the implementation of a summer program, a dual enrollment course, and professional teacher development training in rural high schools in West Tennessee. Our unique population compositions in Lauderdale and McNairy Counties in West Tennessee will provide insight into the impact of cultural and social differences in learning acquisition for CLS and PHIT concepts, thereby allowing us to uniquely tailor our experiences to different community and cultural settings. We will use novel outcomes-based educational approaches that apply project-based learning strategies to real-world social determinants of health scenarios and work-based simulation strategies with real clinical data and samples and will disseminate educational curricula, materials, and research outcomes to enhance community health-based literacy.

PI_NAMEs: MOORE, JACEN SHANNON (contact)

PROGRAM_OFFICER_NAME: FAUPEL-BADGER, JESSICA

PROJECT_TERMS: academic standard;Address;Ally;Area;Attention;Award;Awareness;Bachelor's Degree;career;career awareness;career development;Clinical;Clinical Data;clinical development;Cognitive;cognitive process;college;Communication;Communities;Community Health;community partnership;Continuing Education;County;COVID-19 pandemic;Data;Data Science;design;Development;Dual Enrollment;Education;education research;Educational Curriculum;Educational Materials;Educational process of instructing;Educational Status;effectiveness evaluation;effectiveness outcome;Ethnic Origin;experience;Exposure to;Focus Groups;Goals;Health;health care settings;health information technology;Health Occupations;Health Professional;Health Sciences;health training;Healthcare;high school;High School Faculty;High School Student;Human Resources;improved;Information Technology;insight;interdisciplinary approach;interest;Interview;Knowledge;Knowledge acquisition;Laboratories;Laboratory Research;Learning;learning strategy;literacy;Management Information Systems;Mentored Clinical Scientist Development Program;Methods;Next Generation Science Standards;novel;operation;Outcome;Outcomes Research;outreach;Pathway interactions;Patients;Policy Maker;Population;Process;profession allied to medicine;Program Development;programs;project-based learning;Public Health;Qualifying;Quasi-experiment;recruit;Research;Research Activity;research faculty;Research Methodology;Resources;response;role model;Rural;rural area;Rural Community;rural counties;Rural Health;rural underserved;Sampling;Schools;Science;science education;science teacher;Side;simulation;skill acquisition;skills;skills training;social;social health determinants;Stress;Students;success;summer program;teacher;Teacher Professional Development;Tennessee;tool;Training;Training and Education;undergraduate student;Underrepresented Students;underserved area;Underserved Population;underserved students;United States National Institutes of Health;Universities;university student;Vocational Education;Work;World Health

PROJECT_TITLE: From High School to Health Care: Lab and Data Science Pathways for Success

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-H(55)R]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Eye Disease and Disorders of Vision;Machine Learning and Artificial Intelligence;Neurofibromatosis;Neurosciences;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE  In children with brain tumors impacting their vision, physicians have difficulty determining when the treatment is working. We will improve upon the very basic and often inaccurate human measurements of tumor size by developing quantitative imaging tools to make accurate and automated measures of tumor volume and shape. From these measures, we will create methods that will enable clinical trials and physicians to make informed decisions about the treatment’s success and whether the child will recover their vision.

PI_NAMEs: AVERY, ROBERT ANDREW (contact);LINGURARU, MARIUS GEORGE

PROGRAM_OFFICER_NAME: TATA, DARAYASH B

PROJECT_TERMS: 3-Dimensional;8 year old;Address;Affect;Agreement;Anterior;automated segmentation;Biological Markers;Birth;Blindness;brain magnetic resonance imaging;Brain Neoplasms;cancer predisposition;Categories;Central Nervous System;Child;Childhood;Childhood Brain Neoplasm;Clinical;clinical care;clinical predictors;Clinical Trials;clinically relevant;cohort;Complete Blindness;Data;data harmonization;Devices;Disease Progression;Enrollment;Excision;experience;Friends;functional outcomes;Future;Glioma;Goals;graphical user interface;Growth;Heterogeneity;Human;Image;image processing;Imaging Device;imaging modality;imaging software;improved;Incidence;machine learning algorithm;machine learning method;Magnetic Resonance Imaging;Manufacturer;Measurement;Measures;Methods;Modeling;Monitor;Neurofibromatoses;Neurofibromatosis 1;novel;Operative Surgical Procedures;Optic Chiasm;Optic Nerve;Optic Nerve Glioma;Optics;Outcome;Pathway interactions;Pattern;Pediatric Neoplasm;Phase III Clinical Trials;Physicians;precision medicine;Prediction of Response to Therapy;Protocols documentation;quantitative imaging;Recommendation;Resolution;response;Severity of illness;Shapes;standard of care;Standardization;Structure;success;Syndrome;Time;Treatment Failure;treatment response;tumor;Tumor Volume;two-dimensional;user-friendly;Vision;Visual;Visual Acuity;Visual Pathways;Visualization

PROJECT_TITLE: Quantitative MRI for Pediatric Optic Pathway Glioma Treatment Response


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Bioengineering;Digestive Diseases;Regenerative Medicine;Wound Healing and Care

ORG_CITY: SCOTTSDALE

ORG_NAME: MAYO CLINIC ARIZONA

ORG_STATE: AZ

PHR: Narrative The larynx governs our most basic life-sustaining functions and serves as the foundation of our self-identity. Even the most minor aberration within this delicate and complex structure can result in life-altering or life- ending consequences, disrupting the ability to breathe, swallow, and voice. The goal of this project is to deliver a bioengineered implant for larynx reconstruction, a novel clinical approach to restore a patient’s own voice, normal breathing, and swallowing.

PI_NAMEs: LOTT, DAVID G (contact)

PROGRAM_OFFICER_NAME: KOPF, LISA MARIE

PROJECT_TERMS: Acceleration;Anatomy;Aorta;Atrophic;Biomedical Engineering;Breathing;Canis familiaris;Child;Cicatrix;Clinical;Complex;Coughing;Deglutition;design;Development;Epithelium;experience;Family;Feasibility Studies;feeding;Foundations;functional outcomes;functional restoration;Generations;Goals;Harvest;healing;homograft;Human;Immobilization;Immune response;Immunology;Implant;implant design;improved;improved outcome;in vivo;in vivo Model;Laryngeal Mucosa;Larynx;Left;Legal patent;Life;Minor;Modeling;Morbidity - disease rate;Mucous body substance;multidisciplinary;Muscle;novel;Operative Surgical Procedures;Patients;Performance;Physics;Positioning Attribute;Process;Prosthesis;prototype;Quality of life;reconstruction;Reconstructive Surgical Procedures;regenerative;restoration;Robot;scaffold;Second Look Surgery;Shapes;Site;Social isolation;Speech-Language Pathology;stem cell biology;Stomach;Structure;Surgical Management;Testing;Tissues;Tracheostomy Tube;Tube;Voice;Work;wound;wound healing

PROJECT_TITLE: Optimizing a patient-specific regenerative larynx implant for restoration of voice

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Drug Abuse (NIDA only);Health Services;Primary Health Care;Sleep Research;Substance Misuse

ORG_CITY: DENVER

ORG_NAME: NATIONAL JEWISH HEALTH

ORG_STATE: CO

PHR: PROJECT NARRATIVE Long-term reliance on sedative hypnotics is all too common since many hypnotic users find hypnotic discontinuation difficult to achieve. Open-label physician-supervised medication tapering (SMT) combined with cognitive behavioral insomnia therapy (CBTI) produces short-term abstinence but these treatments are difficult to access in primary care where most hypnotic users present. This project will provide primary care providers training in SMT and test a combination of this treatment with a highly scalable digital version of CBTI (dCBTI) so as to provide wider access of these interventions in primary care settings where they are most needed.

PI_NAMEs: SMITH, ELIZABETH DEVON (contact)

PROGRAM_OFFICER_NAME: SEYMOUR, KAREN ELIZABETH

PROJECT_TERMS: Abstinence;Achievement;actigraphy;Acute;Address;Adoption;Aftercare;Age;age group;Anxiety;Behavioral;Belief;Chronic;Clinical;clinical practice;Cognitive;Colorado;Combined Modality Therapy;comorbidity;Complex;cost effective;cost effective intervention;Dangerousness;Data;Dependence;design;diaries;digital;Disease;Disease remission;Dose;efficacy testing;Enrollment;Ethnic Origin;evidence base;experience;falls;Fatigue;follow-up;Frequencies;Future;Goals;human old age (65+);hypnotic;impaired driving performance;implementation evaluation;implementation science;implementation strategy;implementation/effectiveness;improved;Individual;Initial Insomnia;Intervention;Interview;Lead;Maintenance;Measures;medical schools;medical specialties;Modeling;Monitor;Moods;Morbidity - disease rate;Nonpharmacologic Therapy;open label;Participant;Patient Self-Report;Patients;Performance;Pharmaceutical Preparations;Physicians;practice-based research network;Primary Care;primary care clinic;primary care patient;primary care provider;primary care setting;primary outcome;Process;Protocols documentation;Provider;Public Health;Quality of life;Questionnaires;randomized trial;Reporting;Research;response;Risk;Sampling;secondary outcome;sedative;Severities;sex;Sleep;sleep behavior;sleep difficulty;Sleeplessness;Structure;symptomatic improvement;Symptoms;System;Testing;theories;Therapeutic Intervention;Time;Training;Universities;Withdrawal Symptom

PROJECT_TITLE: Enhancing Hypnotic Medication Discontinuation in Primary Care through Supervised Medication Tapering and Digital Cognitive Behavioral Insomnia Therapy

STUDY_SECTION: BMHO

STUDY_SECTION_NAME: Biobehavioral Medicine and Health Outcomes Study Section[BMHO]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Bioengineering;Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

ORG_CITY: CHARLOTTE

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF NORTH CAROLINA CHARLOTTE

PHR: As many complex diseases, e.g., Alzheimer’s disease, involve multiple cell types, it is crucial to extract cell type-specific information from widely available, low-cost bulk tissue data. The proposed study develops computational tools that can select marker genes and estimate the proportion of each cell type. The outcomes are a key part to understand these diseases and will serve further applications including cell-type specific differential expression and co-expression analyses.

PI_NAMEs: CHEN, DUAN  (contact);LI, SHAOYU ;WANG, XUE

PROGRAM_OFFICER_NAME: WANG, PEGGY

PROJECT_TERMS: Address;Algorithms;Alzheimer's Disease;Benchmarking;Biological;biomarker identification;Cell Extracts;cell type;Cells;Characteristics;Complex;Computational algorithm;Computer Hardware;computerized tools;Control Groups;cost;Data;Data Analyses;Data Compression;Data Set;data space;differential expression;Disease;Exhibits;fundamental research;Gene Expression;Genes;Genetic Markers;geometric structure;Geometry;Graph;Human;Individual;innovation;Laplacian;large datasets;Learning;mathematical model;Mathematics;Methods;Modeling;Modernization;Noise;Outcome;Pharmaceutical Preparations;Process;Randomized;Research;Sorting;Structure;Techniques;Tissue Sample;Tissues;Transcription Alteration;transcriptome sequencing;Validation;Work

PROJECT_TITLE: Geometric structures guided learning model and algorithms for bulk RNAseq data analysis


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences

ORG_CITY: La Jolla

ORG_NAME: SALK INSTITUTE FOR BIOLOGICAL STUDIES

ORG_STATE: CA

PHR: PROJECT NARRATIVE Neurons of the brain age in parallel with the individual and we can model changes in aged and diseased human neurons in a dish. I have reproducible evidence from multiple genetically distinct individuals with Alzheimer’s disease (AD), that shows the metabolic pathways involved in making the DNA building blocks are altered, potentially leading to increased DNA damage and other metabolic dysfunction. With new technologies, we will quantify changes in DNA quality, investigate two key regulators of this metabolic pathway, and profile non-genetic DNA changes associated with age and AD.

PI_NAMEs: JONES, JEFFREY RAY (contact)

PROGRAM_OFFICER_NAME: BARRETT, PAUL JOHN

PROJECT_TERMS: Address;Age;age-related disease;aged;Aging;aging process;aging related disease;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease patient;Analytical Chemistry;ATAC-seq;Bioenergetics;Biological;Biological Aging;Biological Assay;Biological Models;Brain;Carbon;cdc Genes;CDC2 gene;Cell Cycle;Cells;ChIP-seq;Chromosomal Instability;clinically relevant;Cognitive;Cognitive aging;cohort;Data;Data Set;defined contribution;Dementia;Deoxyribonucleotides;Development;differential expression;Disease;DNA;DNA biosynthesis;DNA Damage;DNA Repair;DNA Structure;Down-Regulation;effective therapy;Elderly;Ensure;Epigenetic Process;epigenome;Event;experience;Fibroblasts;Functional disorder;Future;G1 Phase;Gene Expression Regulation;Generations;Genes;Genetic;Genetic Transcription;Genome;Homeostasis;Human;human disease;human old age (65+);Impaired cognition;In Vitro;in vivo;Individual;Induced Neurons;induced pluripotent stem cell;innovation;insight;Knowledge;Life;life span;Maps;Mediating;Metabolic;Metabolic dysfunction;Metabolic Pathway;Metabolism;metabolomics;Methods;methyl group;Mitochondria;Mitochondrial DNA;mitochondrial genome;Mitosis;Modeling;multi-electrode arrays;Neurons;new technology;non-genetic;normal aging;Nuclear;nucleotide metabolism;Nucleotides;Pathogenesis;Pathologic;pathological aging;Pathway interactions;Pharmaceutical Preparations;phosphoproteomics;Population;Post-Translational Protein Processing;postmitotic;Process;Production;Proteins;Publishing;Regulation;Rejuvenation;repaired;Repression;Reproducibility;Research;Resolution;Ribonucleotides;RNA;Role;RRM1 gene;Scientific Advances and Accomplishments;Signal Pathway;Signal Transduction;single cell analysis;single cell sequencing;System;Techniques;Technology;Testing;Therapeutic;therapeutic target;Thinking;Time;tool;Transcriptional Regulation;Up-Regulation

PROJECT_TITLE: Alterations in neuronal metabolic pathways contribute to human cognitive aging and are exacerbated in Alzheimer's disease

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development Facilitating The Transition to Independence Study Section[AGCD-1]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Congenital Structural Anomalies;Digestive Diseases;Genetics;Kidney Disease;Orphan Drug;Pediatric;Rare Diseases

ORG_CITY: WASHINGTON

ORG_NAME: GEORGETOWN UNIVERSITY

ORG_STATE: DC

PHR: PROJECT NARRATIVE Alport syndrome is a rare inherited disease that causes chronic kidney disease, and there are few available treatment options. This proposal investigates an FDA approved drug in a mouse model of Alport syndrome. If this drug is able to delay the onset of kidney disease in the mouse model, it would be the first step in a long journey towards repurposing the drug to treat Alport syndrome in humans.

PI_NAMEs: JONES, BRYCE ALAN (contact)

PROGRAM_OFFICER_NAME: MARIC-BILKAN, CHRISTINE

PROJECT_TERMS: Acids;Adrenal Glands;Age;Agonist;Arginine;Bile Acids;Binding;Biochemical;biological adaptation to stress;Biopsy;Blood Pressure;Chronic Kidney Failure;Clinical;Clinical Trials;Collagen;Collagen Type IV;Data;Defect;Diabetic Nephropathy;Diet;dimethylargininase;Disease Progression;Disinhibition;drug repurposing;effective therapy;Etiology;FDA approved;Female;Fibrosis;Fluorescein-5-isothiocyanate;fluorescence lifetime imaging;Gene Activation;Generations;Genes;Genetic Transcription;Genotype;Glomerular Filtration Rate;Glycolysis;Goals;Hereditary Disease;Hereditary nephritis;Human;Image;Immune response;Immunohistochemistry;Inflammation;Inherited;Investigational Drugs;Kidney;kidney biopsy;Kidney Diseases;kidney fibrosis;Kidney Transplantation;Label;Left;lipid biosynthesis;Liver;male;Measures;Mediating;Metabolic;Metabolism;Metadata;Microscope;Modeling;mouse model;multi-photon;Mus;NADH;Nitric Oxide Synthetase Inhibitor;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;novel;Nuclear Receptors;Nuclear Translocation;Organ;Oxidative Stress;Pathway interactions;Patients;Pharmaceutical Preparations;pharmacologic;Phase;prevent;Primary biliary cirrhosis;promoter;Proteolysis;Ramipril;Rare Diseases;receptor;Receptor Activation;receptor expression;Recovery;Renin-Angiotensin-Aldosterone System;Repression;Resolution;Risk Factors;second harmonic;Serum;Severities;Slide;Small Intestines;Techniques;Testing;Tissues;Transactivation;transcription factor;Transgenic Mice;treatment duration;Urine;Work

PROJECT_TITLE: Obeticholic acid as a novel treatment for Alport syndrome


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Colorectal Cancer;Digestive Diseases;Patient Safety;Precision Medicine;Prevention

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative The ability to detect circulating tumor DNA (ctDNA) and use ctDNA to inform treatment decisions are emerging as powerful tools. Two transformative applications are the detection and treatment of residual disease in colon cancer and real-time monitoring of therapeutic response in metastatic GI cancers.

PI_NAMEs: PARIKH, APARNA RAJ (contact)

PROGRAM_OFFICER_NAME: RADAEV, SERGEY

PROJECT_TERMS: Adjuvant;Adjuvant Chemotherapy;Adjuvant Study;Adjuvant Therapy;Advisory Committees;arm;Biological Markers;biomarker driven;Biometry;Blood;Cancer Patient;career;chemotherapy;Clinical;clinical application;Clinical Trials;colon cancer patients;Colon Carcinoma;Colorectal Cancer;Data;Detection;Detection of Minimal Residual Disease;Disease;Disease Progression;Disease-Free Survival;DNA analysis;Doctor of Philosophy;Early Diagnosis;Early identification;Early Intervention;Early treatment;effective therapy;Emerging Technologies;Enrollment;Excision;follow-up;Funding;General Hospitals;Goals;high risk;Image;Immunotherapy;improved;ineffective therapies;Institution;International;Intervention;large datasets;liquid biopsy;Malignant neoplasm of gastrointestinal tract;Malignant Neoplasms;Massachusetts;Mentors;Mentorship;Methods;Modality;Monitor;neoplastic cell;new technology;novel;novel strategies;Oncology;Operative Surgical Procedures;Outcome Assessment;Patient Outcomes Assessments;Patient-Focused Outcomes;Patients;Postoperative Period;predicting response;Prediction of Response to Therapy;prognostic value;prospective;Prospective Studies;radiological imaging;Randomized;real time monitoring;Recurrence;Research Personnel;Residual Neoplasm;Resources;response;Risk;Risk Reduction;Serum;Signal Transduction;Solid Neoplasm;standard measure;standard of care;Systemic Therapy;targeted treatment;Technology;Testing;Time;tool;Toxic effect;Treatment Effectiveness;Treatment Efficacy;Treatment Failure;treatment response;trial design;tumor DNA;Tumor Markers;United States;Work

PROJECT_TITLE: Systematic liquid biopsy to monitor residual disease and treatment efficacy in gastrointestinal cancer patients

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Intellectual and Developmental Disabilities (IDD);Mental Health;Mental Illness;Neurosciences;Schizophrenia;Serious Mental Illness

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

PHR: NARRATIVE Autism spectrum disorder (ASD) and schizophrenia are associated with an increased ratio of excitatory-to- inhibitory (E/I) neurotransmission in brains of affected individuals, raising the possibility that therapeutics designed to restore E/I balance could be effective in treating these disorders. Fast-spiking parvalbumin (PV) GABAergic interneurons (PV-IN) are critical regulators of E/I balance and owe their ability to generate high- frequency action potentials in part to the restricted expression and function of Kv3.1 (gene KCNC1) voltage- gated potassium channels, mutations in which are associated with ASD in humans. Here, we propose to employ high-throughput screening, medicinal chemistry, automated and manual patch clamp electrophysiology, and electrophysiological recordings from identified PV-IN to develop a series of potent and specific Kv3.1 potentiators to restore E/I balance in ASD and schizophrenia.

PI_NAMEs: DENTON, JEROD S. (contact)

PROGRAM_OFFICER_NAME: MANDELBLAT-CERF, YAEL

PROJECT_TERMS: Action Potentials;Affect;American;autism spectrum disorder;Behavior;Biological Assay;Biology;Brain;Chemicals;Clinical Treatment;Cognition;Corpus striatum structure;cost;de novo mutation;design;Development;Disease;DNA Sequence Alteration;drug discovery;Drug Kinetics;drug metabolism;efficacy validation;Electrophysiology (science);Equilibrium;Fire - disasters;Fluorescence;Frequencies;Genes;Genetic;Goals;High Frequency Oscillation;high reward;high risk;high throughput screening;Human;Impairment;In Vitro;in vivo;Individual;information processing;Interneurons;Libraries;Manuals;mathematical model;meter;model of autism spectrum disorder;Molecular Target;motor behavior;mouse model;Mus;Mutation;neural circuit;neurodevelopment;neurotransmission;novel;Nucleus Accumbens;Output;Parvalbumins;patch clamp;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacologic;Play;Potassium Channel;Prefrontal Cortex;Productivity;Property;Quality of life;Role;Schizophrenia;Sensory;Series;Shaw potassium channel protein family;Slice;small molecule;Synaptic Transmission;Therapeutic;voltage;Voltage-Gated Potassium Channel

PROJECT_TITLE: Development of Kv3.1 potentiators for correcting fast-spiking-interneuron hypofunction in schizophrenia and autism spectrum disorder

STUDY_SECTION: DMPB

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology B Study Section[DMPB]


NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Urologic Diseases

ORG_CITY: MADISON

ORG_DEPT: UROLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE The overarching goal of the Interactions Core at the University of Wisconsin School of Medicine and Public Health is to foster and support collaborative transdisciplinary scientific research to enhance our understanding of the causes, development, progression, and personal, societal, and environmental impacts of non-cancerous urologic conditions, including urinary tract infection, kidney and bladder stones, prostatic enlargement, lower urinary tract symptoms (pain, incontinence, neurogenic bladder, and other voiding dysfunctions), male reproductive disorders, and developmental (congenital) abnormalities of the urinary tract. We will provide intellectual leadership and logistic support to the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Urology Centers and Programs collectively known as CAIRIBU – Collaborating for the Advancement of Interdisciplinary Research in Benign Urology. Specifically, the Interactions Core will identify and facilitate opportunities for cross-CAIRIBU interactions and collaborations with new urology investigators, promote research findings and resources to the broader benign urology research community, and build the community and diversity of benign urology basic, clinical, and population scientists that are actively studying benign urologic diseases.

PI_NAMEs: PENNISTON, KRISTINA L (contact)

PROGRAM_OFFICER_NAME: NIHALANI, DEEPAK

PROJECT_TERMS: Acceleration;Address;American;Area;Award;Basic Science;Benign;Bladder;Bladder Calculi;care outcomes;career development;Categories;Cellular biology;Clinical;Clinical Treatment;Clinical Trials;Collaborations;Communication;Communities;community building;comorbidity;cost;Detection;Development;diagnostic criteria;Diagnostic tests;Disease;Disease Management;Disease Progression;Education;effective intervention;effective therapy;Effectiveness;efficacy evaluation;Environment;Environmental Impact;Environmental Risk Factor;epidemiology study;Etiology;Evaluation;evidence base;experience;Fostering;Functional disorder;Funding;Funding Opportunities;Future;Genetic;Genetic Predisposition to Disease;Genitourinary system;Goals;Health;health care delivery;health care disparity;Home;Human Resources;improved;Incontinence;Individual;Infection;Infrastructure;innovation;interdisciplinary approach;Interdisciplinary Study;Kidney;Kidney Calculi;Knowledge;Leadership;leadership development;Link;Logistics;lower urinary tract symptoms;male;Measures;medical schools;meetings;member;Mental disorders;Mentored Clinical Scientist Development Program;Mentors;Metabolic;Methodology;Mission;Modeling;multidisciplinary;National Institute of Diabetes and Digestive and Kidney Diseases;Nature;Neurogenic Bladder;Outcome;outcome disparities;outreach;Pain;Patient-Focused Outcomes;Patients;Performance;Persons;Phenotype;Physiological;Physiology;Population;Positioning Attribute;prevent;Prevention;Principal Investigator;Process;Productivity;Program Development;Program Evaluation;programs;Prostatic;Public Health;Quality of life;reproductive organ;reproductive system disorder;Research;Research Personnel;Research Proposals;Resource Sharing;Resources;Risk;Science;Scientist;Societies;success;Symptoms;System;Teleconferences;Training;Translational Research;Universities;Ureter;Urethra;Urinary tract;Urinary tract infection;Urogenital Diseases;urologic;Urologic Diseases;Urology;virtual;web site;Wisconsin;Work

PROJECT_TITLE: Urology Centers Program Interactions Core (U24)


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Prevention;Primary Health Care;Social Determinants of Health

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

PHR: PROJECT NARRATIVE The high prevalence and associated negative impact of trauma (i.e. child abuse, intimate partner violence) on the mental and physical health of people living with HIV and their engagement in HIV care underscore the need for systematically addressing trauma within HIV services. Trauma-informed Care (TIC) is an organizational structure and treatment framework that involves understanding, recognizing, and responding to the effects of trauma, and has shown promise in impacting the mental and physical health of patients and their care providers in non-HIV settings; however, limited published literature exists about methods for and the effectiveness of integrating TIC within HIV primary care (TI-HIV care). Responsive to our prior pre-implementation study that demonstrated critical gaps in staff TIC training and support in TIC provision across Ryan White-funded HIV Clinics (RWCs) in the Southeastern US, the proposed study develops and pilots culturally- and contextually- tailored TI-HIV care trainings and TIC implementation facilitation processes and examines their preliminary effectiveness on provider and clinic-level outcomes at two high-volume RWCs in Metro Atlanta.

PI_NAMEs: KALOKHE, AMEETA SHIVDAS;SALES, JESSICA A (contact)

PROGRAM_OFFICER_NAME: SENN, THERESA ELAINE

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Adherence;Administrator;Adoption;Age;antiretroviral therapy;Attitude;Behavior;behavioral health;burnout;care providers;Caring;Child Abuse;Clinic;Collaborations;comorbidity;Consensus;Continuity of Patient Care;cost effective;Data;Dose;Effectiveness;effectiveness outcome;effectiveness/implementation trial;Emotional;Epidemic;ethnic minority;ethnic minority population;Evaluation;Evidence based treatment;experience;falls;federal poverty level;Feedback;Focus Groups;Funding;Future;Guidelines;Health;Health Promotion;High Prevalence;HIV;HIV diagnosis;Hybrids;implementation facilitation;implementation outcomes;implementation strategy;implementation study;improved;Individual;informant;innovation;Interactive Systems Framework;Interview;intimate partner violence;Job Satisfaction;Literature;Low income;Medicaid;men;Mental Health;Methodology;Methods;Morale;mortality;Opportunistic Infections;organizational structure;Outcome;Patient-Focused Outcomes;Patients;Persons;physical abuse;physical conditioning;pilot test;Primary Care;primary care services;Process;Protocols documentation;Provider;Public Health Education;Publishing;racial minority;Recording of previous events;referral services;Reporting;Research;response;screening;screening guidelines;Self Care;Self Efficacy;Service setting;Services;Sexual abuse;Site;Social Work;Source;substance use;Surveys;Survivors;System;Testing;Training;transgender;Trauma;trauma exposure;Uninsured;United States Health Resources and Services Administration;United States National Institutes of Health;Viral;Woman;Work

PROJECT_TITLE: Trauma informed care

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


NIH_SPENDING_CATS: Bioengineering;Genetics

ORG_CITY: KNOXVILLE

ORG_DEPT: PHYSICS

ORG_NAME: UNIVERSITY OF TENNESSEE KNOXVILLE

PHR: PROJECT NARRATIVE Cell division is an essential process for a cell to produce viable progeny. The proposed research will provide a mechanistic understanding of the control mechanisms involved in the formation of bacterial Z-ring and triggering the onset of constriction. These molecular processes are potent targets for new antibacterial drugs.

PI_NAMEs: MANNIK, JAAN  (contact)

PROGRAM_OFFICER_NAME: MILLER, RITA K

PROJECT_TERMS: Actins;Anti-Bacterial Agents;Antibiotics;Bacteria;Binding;Biological Models;Cell Cycle;Cell Cycle Checkpoint;Cell division;Cell Physiology;Cell Survival;Cell Wall;Cells;Chromosome Segregation;Collaborations;Complex;Computer Models;constriction;Coupling;Cytosol;Data;daughter cell;design;DNA biosynthesis;Escherichia coli;experimental study;Filament;Genome;Goals;Growth;Homologous Gene;in vitro Assay;in vivo;Individual;Kinetics;Knowledge;knowledge integration;Link;Lipids;macromolecular assembly;Maps;Membrane;Methods;Microfluidic Microchips;model organism;Modeling;Molecular;Molecular Biology;molecular dynamics;Molecular Genetics;Molecular Structure;novel;Pathway interactions;Peptidoglycan;Pharmaceutical Preparations;Physical condensation;Play;Positioning Attribute;Process;Proliferating;Proteins;Reaction;recruit;Replication Initiation;Research;Role;self assembly;simulation;Structure;superresolution microscopy;targeted treatment;Techniques;Therapeutic;three-dimensional modeling;treadmill;Work;z-ring

PROJECT_TITLE: Coordination mechanisms between cell division and chromosome segregation in E. coli

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MGG-V(02)M]


NIH_SPENDING_CATS: Bioengineering;Clinical Research

ORG_CITY: DAVIS

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: PROJECT NARRATIVE Excessive or inappropriate recruitment of immune cells is a major driver of tissue damage in inflammation-associated diseases including atherosclerosis, arthritis, and autoimmune diseases. The migration of cancer cells causes dissemination and metastasis which greatly reduces survival rates. Understanding the basic mechanisms that allow cells to maintain migratory behavior will suggest new therapeutic strategies to improve outcomes in disease.

PI_NAMEs: COLLINS, SEAN RYAN (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TERMS: Actins;Actomyosin;Address;Affect;Arthritis;Atherosclerosis;Autoimmune Diseases;Behavior;Behavior Control;Biochemical;Biological Process;Biosensor;cancer cell;cell motility;Cell Polarity;cell type;Cells;Chemicals;Cues;Cytoskeleton;Defect;depolymerization;Development;Disease;Disseminated Malignant Neoplasm;Drug Targeting;Elements;Environment;Experimental Genetics;experimental study;F-Actin;Family;Feedback;Fluorescence Resonance Energy Transfer;Glioblastoma;Goals;Guanosine Triphosphate Phosphohydrolases;HL60;Image;Immune;Immune response;improved outcome;Individual;Inflammation;Inflammatory;Leukocytes;Light;Maintenance;Maps;Measurement;Measures;Mediating;Mediator;Microscopy;migration;Modeling;Molecular;Molecular Target;Mutation Analysis;Nature;Neoplasm Metastasis;neutrophil;new therapeutic target;novel therapeutic intervention;Optics;optogenetics;Output;Pattern;Play;Process;Proteins;Proteomics;receptor;recruit;redshift;Regulation;Research;Resolution;response;rho;rho GTP-Binding Proteins;Role;scaffold;segregation;Signal Pathway;Signal Transduction;Structure;Survival Rate;System;Testing;Tissues;tool;Travel

PROJECT_TITLE: Actin gating of crosstalk between Rho GTPases in cell migration

STUDY_SECTION: CMT

STUDY_SECTION_NAME: Cellular and Molecular Technologies Study Section[CMT]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Aging;Assistive Technology;Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Parkinson's Disease;Physical Rehabilitation;Rehabilitation

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: RELEVANCE (See instructions): Our proposed system has the potential to dramatically improve clinician decision-making and slow the  functional decline caused by Parkinson’s disease. We envision a future where patients may be remotely  guided through treatment and monitored such that clinicians can rapidly and effectively provide assistance  outside of clinical settings. Our research contributions may also support the management and monitoring of  a broad category of other chronic diseases.

PI_NAMEs: BERTASIUS, GEDIMINAS ;BROWNER, NINA M.;FUCHS, HENRY  (contact);LEWEK, MICHAEL D;SZAFIR, DANIEL ;SZAFIR, DANIELLE

PROGRAM_OFFICER_NAME: AJISAFE, TOYIN DELE

PROJECT_TERMS: 3-Dimensional;Address;Area Health Education Centers;Augmented Reality;automated reasoning;Categories;Chronic Disease;Clinic;Clinic Visits;Clinical;Decision Making;deep learning model;deep neural network;design;Development;Exercise;Eyeglasses;Feedback;functional decline;Future;Healthcare;Home;Home environment;Human;improved;Instruction;Investigation;Life;Medical;Modeling;Monitor;motor symptom;multimodality;neural network architecture;neurological rehabilitation;North Carolina;novel;Parkinson Disease;Participant;Patient Care;Patients;Performance;Persons;physical therapist;Physical therapy exercises;Privacy;Process;programs;Provider;reconstruction;Rehabilitation therapy;Research;rural area;Semantics;sensor;Shoes;Societies;System;Techniques;Technology;Visual Perception;wearable data;With laterality;Work;wristband

PROJECT_TITLE: SCH: An Augmented Reality Neurorehabilitation System for Monitoring and Management of Motor Symptoms of Parkinson's Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-VH-N(50)R]


NIH_SPENDING_CATS: Biomedical Imaging;Breast Cancer;Cancer;Clinical Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Women's Health Research

ORG_CITY: HONOLULU

ORG_NAME: UNIVERSITY OF HAWAII AT MANOA

ORG_STATE: HI

PHR: Project Narrative. The proposed studies are relevant to public health because they have the potential to increase the effectiveness of diagnostic mammography and tomosynthesis. Thus, this advance is expected to have a high impact to the health and well being of women because mammography and tomosynthesis are currently the primary diagnostic tools for early breast cancer detection, and over two-thirds of women diagnosed through these imaging modes do not have cancer, resulting in many unnecessary painful invasive procedures. This is relevant to the part of NIH's mission which focuses on the prevention of disease by supporting research in the diagnosis of human diseases.

PI_NAMEs: GIGER, MARYELLEN L.;SHEPHERD, JOHN ALAN (contact)

PROGRAM_OFFICER_NAME: DARDZINSKI, BERNARD JOSEPH

PROJECT_TERMS: Address;Age;Benign;Biological;Biological Markers;Biopsy;Breast;Breast Cancer Detection;breast cancer diagnosis;Breast Cancer Early Detection;breast density;breast imaging;breast lesion;Cancer Detection;cancer subtypes;cancer type;Characteristics;Clinical;clinical risk;clinical translation;Communities;computer aided detection;computer-assisted diagnostics;contrast enhanced;Contrast Media;deep learning model;design;Diagnosis;Diagnostic;diagnostic accuracy;Diagnostic Imaging;Diagnostic Specificity;diagnostic tool;Digital Breast Tomosynthesis;Digital Mammography;disorder prevention;Effectiveness;Emerging Technologies;experience;FDA approved;Goals;Health;Hormone Receptor;human disease;Image;Image Analysis;imaging system;improved;innovation;insight;Lesion;Lipids;Machine Learning;Malignant - descriptor;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Gland Parenchyma;Mammography;Measures;medical specialties;Methods;Mission;Morphology;Non-Malignant;Outcome;Pain;Participant;Performance;Personal Satisfaction;Probability;Procedures;programs;prospective;Proteins;Protocols documentation;Public Health;quantitative imaging;radiologist;Reader;Recommendation;Research;research clinical testing;Research Support;Risk Factors;screening;Sensitivity and Specificity;Specificity;spectrograph;standard of care;System;Technology;Texture;Tissues;tomosynthesis;United States National Institutes of Health;Water;Woman;women's diagnosis

PROJECT_TITLE: Lesion Composition and Quantitative Imaging Analysis on Breast Cancer Diagnosis


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cardiovascular;Cerebrovascular;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Vascular Contributions to Cognitive Impairment and Dementia (VCID);Women's Health Research

ORG_CITY: NEW ORLEANS

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: NARRATIVE This study will inform strategies that may reduce Alzheimer’s Disease disparities by identifying the influence of cardiovascular risk burden in childhood on brain health indicators decades later in midlife. The proposed study represents a unique opportunity to investigate this issue and, has the potential to lead to changes in pediatric clinical practice guidelines.

PI_NAMEs: BAZZANO, LYDIA  (contact);CARMICHAEL, OWEN T.;URBINA, ELAINE MOTT

PROGRAM_OFFICER_NAME: PERCY-LAURRY, ANTOINETTE LOIS

PROJECT_TERMS: Acceleration;Address;Affect;Age;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease related dementia;Alzheimer's disease risk;Biological Markers;Black Populations;Blood;Blood Pressure;Blood Vessels;blood-based biomarker;boys;brain health;cardiovascular health;cardiovascular risk factor;Cardiovascular system;Child;Childhood;Clinical;clinical development;Clinical Practice Guideline;Cognitive;cognitive performance;cognitive testing;cohort;Cohort Studies;Collaborations;critical period;Data;data harmonization;data resource;Data Set;dementia risk;Development;Disadvantaged;disease disparity;Disparity;Education;effective therapy;Equity;Ethnic Population;Event;Exposure to;Factor Analysis;follow-up;food security;Generations;geographic disparity;Geography;girls;Glucose;Green space;Growth;Health;health data;health disparity;Heart;human old age (65+);Impaired cognition;in utero;indexing;Individual;Indole-3-Carbinol;International;Investments;Joints;Knowledge;late life;Life;Life Cycle Stages;Lipids;Longitudinal Studies;Measures;men;Metabolic;middle age;National Heart, Lung, and Blood Institute;National Institute on Aging;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;open data;Participant;pollutant;Population;population based;Postmenopause;Premenopause;Prevalence;Prevention;Process;progression risk;prospective;public health relevance;racial disparity;racial population;Recording of previous events;Reproducibility;Research;research study;Risk Factors;Sampling;sex;sex variable;socioeconomic disadvantage;socioeconomics;Time;United States National Institutes of Health;Vascular System;Woman;Work;Youth

PROJECT_TITLE: I3C DECADE: Disparities and Equity in Childhood Cardiovascular Exposures and Alzheimer's Dementia

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-L(90)R]


NIH_SPENDING_CATS: Congenital Structural Anomalies;Kidney Disease;Pediatric;Polycystic Kidney Disease

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative Defective electrical signaling of polycystin ion channels is considered the primary cause for Autosomal Dominant Polycystic kidney Disease (ADPKD). The proposed work will characterize the key regulatory mechanisms of polycystin channel activation at the molecular and cellular level. Knowledge generated in this proposal will shed light on the fundamental principles of polycystin channel activation in primary cilia and how this signaling is defective in ADPKD.

PI_NAMEs: CAO, ERHU ;DELLING, MARKUS G (contact)

PROJECT_TITLE: A comprehensive map of polycystin channel regulation and its implications in polycystic kidney disease

STUDY_SECTION: BPNS

STUDY_SECTION_NAME: Biophysics of Neural Systems Study Section[BPNS]


NIH_SPENDING_CATS: Cancer;Clinical Research;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: SAN ANTONIO

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

ORG_STATE: TX

PHR: To address “PQ9: What methods can be developed to effectively study small or rare populations relevant to cancer research” we will develop organoids of rare neuroendocrine tumors pheochromocytomas and paragangliomas (PPGL). Currently there are no markers of clinical behavior and malignant PPGLs can only be recognized after metastases develop, for which there are few treatment options. PPGL organoids will enable investigation of tumor markers of outcome and drug screen to identify potential new therapies.

PI_NAMEs: DAHIA, PATRICIA LEAL (contact);SORAGNI, ALICE

PROGRAM_OFFICER_NAME: LI, JERRY

PROJECT_TERMS: Address;Adrenal Glands;Aggressive course;anti-cancer research;Area;Behavior;Biological;Biological Models;Biology;Catecholamines;CDK4 gene;Cells;chemotherapy;Clinical;clinical application;clinical heterogeneity;Clinical Management;clinical predictors;Clinical Trials;Data;design;Detection;Development;Diagnosis;Disease;drug candidate;Drug Screening;drug sensitivity;Early Diagnosis;effective therapy;Epithelium;Experimental Designs;Experimental Models;Future;Genetic;high-throughput drug screening;Human;improved;Individual;insight;Investigation;Knowledge;Low Prevalence;Malignant - descriptor;Malignant Neoplasms;Malignant Paraganglionic Neoplasm;Malignant Pheochromocytoma;Metastatic Pheochromocytoma;Methods;Modeling;Molecular;molecular marker;Morphologic artifacts;Neoplasm Metastasis;Nervous System;Neural Crest;neuroendocrine cancer;Neuroendocrine Tumors;novel;novel therapeutics;Organoids;Outcome;Paraganglia structure;Paraganglioma;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;Pheochromocytoma;pluripotency;Population;predict clinical outcome;predictive marker;Primary Neoplasm;Property;Recurrence;Research;Resources;Survival Rate;targeted agent;Testing;Therapeutic;therapeutic evaluation;therapeutic target;transcriptome;tumor;tumor behavior;Tumor Biology;tumor initiation;Tumor Markers;tumor progression;whole genome

PROJECT_TITLE: Addressing biological and therapeutic gaps in rare neuroendocrine cancer with a novel organoid-based model


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: MEMPHIS

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

PHR: PROJECT NARRATIVE (Relevance Statement): Over the past decade, we have developed and characterized orthotopic patient derived xenografts of pediatric solid tumors. In this project, we have used data from genomic, transcriptomic, proteomic, epigenetic, single cell/single nucleus RNA-seq and high-throughput drug screening to identify compelling for in vivo testing. Discoveries from this effort will be directly translated into cooperative group clinical trials.

PI_NAMEs: DYER, MICHAEL A (contact)

PROGRAM_OFFICER_NAME: OLKHANUD, PUREVDORJ BALJINNYAM

PROJECT_TERMS: Acceleration;Affect;anti-cancer research;Area;Basic Science;Biology;burden of illness;cancer cell;Cell Cycle Checkpoint;Cell Line;Cells;Cellular Stress;cellular targeting;Charge;chemotherapy;Child;Childhood Soft Tissue Sarcoma;Childhood Solid Neoplasm;Clinical;Clinical Research;Clinical Trials;Clinical Trials Cooperative Group;clinically relevant;Clone Cells;Collaborations;Communication;Complex;Consent;curative treatments;Data;Dependence;Development;Disease;DNA Damage;DNA Repair;Dose;Drug Combinations;Drug Kinetics;drug use screening;Enhancers;Ensure;Epigenetic Process;Etiology;Evaluation;Exhibits;experience;FRAP1 gene;G2/M Checkpoint Pathway;Gene Expression;Genetic Transcription;genomic data;Genomics;Goals;Government;Health;high-throughput drug screening;Homeostasis;Human;Immunocompromised Host;implantation;improved;improved outcome;in vivo;in vivo evaluation;Journals;Long-Term Survivors;Malignant Childhood Neoplasm;Mitotic;Modeling;molecular targeted therapies;Mus;Nature;neoplastic cell;next generation;novel drug combination;novel therapeutics;Oncogenic;Pathway interactions;patient derived xenograft model;Patients;Persons;Pharmaceutical Preparations;Pharmacodynamics;Phase;Phosphotransferases;PIK3CG gene;Population;Positioning Attribute;pre-clinical;Preclinical Testing;programs;Proteomics;Publishing;Quality of life;Receptor Protein-Tyrosine Kinases;Recurrent disease;Reporting;Research;Research Proposals;response;Rhabdomyosarcoma;Saint Jude Children's Research Hospital;Schedule;Signal Pathway;Signal Transduction;single cell ATAC-seq;single nucleus RNA-sequencing;Soft tissue sarcoma;Solid Neoplasm;Somatic Mutation;standard of care;Standardization;Testing;therapeutic target;Tissues;transcriptomics;Translating;Translational Research;tumor;tumor heterogeneity

PROJECT_TITLE: In Vivo Testing of Novel Drug Combinations for Pediatric Soft Tissue Sarcomas


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Bioengineering;Cancer;Nanotechnology;Orphan Drug;Ovarian Cancer;Rare Diseases;Women's Health Research

ORG_CITY: COLUMBIA

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

ORG_STATE: SC

PHR: PROJECT NARRATIVE Public Health Relevance: Ovarian cancer is the most prevalent mortality from a gynecologic malignancy in US, which results in a pressing need for the development of new treatments for ovarian cancer. This research will develop a polymer-metal nano-complex for the treatment of advanced ovarian cancer through selectively kill cancer cells, including drug-resistant cancer cells, while sparing normal cells. The success of validating this concept will pave the road to take it forward to clinical trial and lead to the control of ovarian cancer.

PI_NAMEs: XU, PEISHENG  (contact)

PROGRAM_OFFICER_NAME: WU, YICONG

PROJECT_TERMS: Affect;anti-cancer;Antineoplastic Agents;Apoptosis;Area Under Curve;Autophagocytosis;BCL2 gene;Biodistribution;cancer cell;cancer drug resistance;Cancer Etiology;Cancer Patient;cancer therapy;cancer type;CASP9 gene;cell killing;Cells;Cessation of life;Chemistry;Chemoresistance;Chemotherapy-Oncologic Procedure;Cisplatin;Clinical;Clinical Trials;Complex;Control Groups;Copper;cytochrome c;Data;Death Rate;Degradation Pathway;density;Deterioration;Development;Disease;Dose;Drug Kinetics;Drug resistance;Endocytosis;ethylene glycol;female reproductive system;Flow Cytometry;Formulation;Galactose;galactose receptor;Half-Life;Head and Neck Cancer;Health;Histologic;human tissue;Immune;Immune response;improved;in vivo;intraperitoneal;Ions;Ligands;Lysosomes;Malignant Breast Neoplasm;Malignant Female Reproductive System Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of ovary;Malignant neoplasm of prostate;Malignant Neoplasms;Maximum Tolerated Dose;Mediating;Membrane Potentials;Metabolic;Metals;Methods;mitochondrial membrane;Modeling;mortality;mouse model;Multi-Drug Resistance;multicatalytic endopeptidase complex;nanocomplexes;nanoparticle;Neoplasm Metastasis;Normal Cell;novel;novel therapeutic intervention;Operative Surgical Procedures;ovarian neoplasm;Oxidation-Reduction;Pathway interactions;Patients;Permeability;Pharmaceutical Preparations;Polymers;Process;Property;Protein Family;public health relevance;Quality of life;Relapse;Research;Resistance;response;Risk;Serum;siRNA delivery;success;Survival Rate;systemic toxicity;tool;tumor;Tumor Debulking;tumor growth;United States;women's diagnosis;Women's mortality

PROJECT_TITLE: Cancer cell selective killing nanoparticle for advanced ovarian cancer treatment

STUDY_SECTION: NANO

STUDY_SECTION_NAME: Nanotechnology Study Section[NANO]


NIH_SPENDING_CATS: Cancer;Neurofibromatosis;Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: MILWAUKEE

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

PHR: Project Narrative Nerve enriched environment and stem cell origin lead to the growth of the malignant peripheral nerve sheath tumor (MPNST) and promote metastasis. NRG1, ERBB3, and CD44, the three essential genes, typically regulate Schwan cell differentiation in the early developmental stage but form a positive feedback loop to stimulate MPNST tumorigenesis and metastasis. Our work is expected to characterize the interactions and regulations among them and evaluate the therapeutic value by interrupting the feedback loop and ultimately inhibit tumor growth and metastasis.

PI_NAMEs: SUN, DAOCHUN  (contact)

PROGRAM_OFFICER_NAME: KAI, MIHOKO

PROJECT_TERMS: Antibodies;Attenuated;Binding;cancer stem cell;CD44 Antigens;CD44 gene;Cell Differentiation process;Cell Lineage;cell motility;Cells;Clinical;clinical application;Clinical Research;Critical Pathways;Data;Development;environmental enrichment for laboratory animals;ERBB2 gene;ERBB3 gene;Essential Genes;Feedback;Focal Adhesion Kinase 1;Growth;Heterogeneity;Human;Hyaluronan;hyperactive Ras;Hyperactivity;inhibitor;Injections;innovation;interest;Interruption;Intervention;Intervention Studies;Invaded;Joints;Knock-out;Label;Lead;Ligand Binding;loss of function;Loss of Heterozygosity;Malignant Neoplasms;MEKs;Membrane Glycoproteins;Metastasis Induction;Modeling;mortality;mouse model;Mus;Neoplasm Metastasis;Neoplasm Transplantation;neoplastic cell;Nerve;Nerve Plexus;Neural Crest;neural initiation;Neuregulin 1;Neuregulins;Neurofibromatosis 1;Neurofibrosarcoma;neurotransmission;NF1 gene;novel;Pathway interactions;Patients;Pharmaceutical Preparations;Phenotype;Plexiform Neurofibroma;Population;prevent;Proliferating;Property;Proto-Oncogene Proteins c-akt;Regulation;Relapse;Resistance;Role;Schwann Cells;sciatic nerve;Signal Transduction;Soft tissue sarcoma;stem;stem cell growth;stem cell population;stem cells;Study models;Survival Rate;System;targeted treatment;Testing;Therapeutic;Therapeutic Effect;TP53 gene;Transgenes;Transgenic Mice;translational study;Transplantation;tumor;tumor growth;tumor heterogeneity;tumor initiation;tumor microenvironment;tumor progression;Tumor Promotion;tumor xenograft;tumorigenesis;Work;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Targeting the Cancer Stem Cells in Malignant Peripheral Nerve Sheath Tumor

STUDY_SECTION: TME

STUDY_SECTION_NAME: Tumor Microenvironment Study Section[TME]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Machine Learning and Artificial Intelligence;Neurosciences;Stroke

ORG_CITY: STANFORD

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative Artificial intelligence methods, particularly deep learning, can be used to improve image quality or synthesize new images from existing data and to predict future imaging. We will apply this to determine its performance for brain metabolic imaging using simultaneous FDG brain PET/MRI in realistic clinical populations, significantly reducing or eliminating the radiotracer dose as well as incorporating non-imaging, clinical data to improve AI-based image synthesis. This will revolutionize brain PET imaging, enable us to examine future disease trajectories in a personalized manner, and lay the groundwork to understand its use for other modalities and in other disease settings.

PI_NAMEs: ZAHARCHUK, GREGORY GEORGE (contact)

PROGRAM_OFFICER_NAME: BABCOCK, DEBRA J

PROJECT_TERMS: acute stroke;Age;Air;Architecture;arterial spin labeling;artificial intelligence method;Biological Markers;Brain;Brain imaging;Cerebrovascular Circulation;Characteristics;chronic stroke;Clinical;Clinical Data;Clinical Trials;Collaborations;convolutional neural network;cost;Cyclotrons;Data;Data Set;deep learning;Dementia;Diagnosis;Diagnostic;Diagnostic Imaging;Discipline of Nuclear Medicine;Disease;disease natural history;Disease Progression;Dose;Epilepsy;FDA approved;fluorodeoxyglucose;fluorodeoxyglucose positron emission tomography;Functional Magnetic Resonance Imaging;Future;Gender;Genetic;genetic information;Genetic Markers;Glioblastoma;Goals;Human;Image;imaging biomarker;imaging modality;imaging study;improved;Link;machine learning model;Magnetic Resonance Imaging;Maps;Measurement;Measures;Medical;Medical Imaging;Metabolic;metabolic imaging;Metabolism;Methods;Modality;Modeling;multimodal data;multimodality;neural network;next generation;patient population;patient safety;Patients;Performance;Phenotype;Physicians;Population;Positron-Emission Tomography;Prevalence;prospective;Protocols documentation;Provider;quantitative imaging;Radiation;Radiation Dose Unit;radiologist;Radiology Specialty;radiotracer;Reader;Recording of previous events;Recurrent tumor;Risk;Risk Factors;Running;Rural Community;sex;Site;Specific qualifier value;stroke patient;structural imaging;targeted imaging;Technology;Tracer;Training;Translating;Travel;tumor;underserved community;Water

PROJECT_TITLE: Next Generation Brain PET Imaging

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]


ORG_CITY: KANSAS CITY

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: Project Narrative Despite its proposed roles in neuronal function and Parkinson's disease, the Mg2+-transporting protein SLC41A1 has not been well characterized. This study aims to use a three-pronged approach that employs functional assays, cryo-electron microscopy, and cellular assays to define its function, molecular mechanism, and cellular role. This study represents the first steps towards understanding the Mg2+-dependent molecular origins of neurodegenerative disorders and it has the potential to lead to novel treatments of and preventative strategies for Parkinson's disease, a debilitating condition which costs the US health system more than $14 billion each year.

PI_NAMEs: ZUBCEVIC, LEJLA  (contact)

PROGRAM_OFFICER_NAME: SARRAF, SHIREEN AKHAVAN

PROJECT_TERMS: Affect;Artificial Membranes;Binding;Binding Sites;Biological Assay;Biophysics;Carrier Proteins;Cell Line;Cell Physiology;Cells;Cellular Assay;Chemicals;Collaborations;conformational conversion;cost;Coupled;Cryoelectron Microscopy;Data;design;Disease;dopaminergic neuron;Ensure;experimental study;fluorescence imaging;Functional disorder;Genes;Grant;Health;Health system;Homeostasis;Housekeeping;Human;Investigation;Ion Channel;Ion Transport;Ions;Knock-out;link protein;Lipid Bilayers;Liposomes;Luciferases;Magnesium;Measures;Mediating;member;Membrane;Membrane Potentials;Metabolism;Mitochondria;mitochondrial membrane;Modeling;Molecular;Mutation;Nerve Degeneration;Neurobiology;Neuroblastoma;Neurodegenerative Disorders;Neurons;new therapeutic target;novel;Oxidative Phosphorylation;Parkinson Disease;Pathogenesis;Permeability;Prevention strategy;Production;professor;Proteins;reconstitution;Research;Resolution;Risk;Role;Sequence Alignment;Site-Directed Mutagenesis;solute;Structure;Testing;Time;virtual;Water;Work

PROJECT_TITLE: Studies of SLC41A1, a Mg2+-Transporting Protein Linked to Parkinson's Disease

STUDY_SECTION: BBM

STUDY_SECTION_NAME: Biochemistry and Biophysics of Membranes Study Section[BBM]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Social Determinants of Health;Tobacco;Tobacco Smoke and Health

ORG_CITY: AUSTIN

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

PHR: PROJECT NARRATIVE Between two and five times as many SM people smoke or use tobacco as their heterosexual counterparts, resulting in disproportionate amounts of tobacco-related morbidity and mortality in SM communities. NIH has designated SM people a health disparity population, yet their tobacco disparities are persisting, and in some cases, worsening. Advancing our understanding of the etiology of SM tobacco use disparities and the potential protective effect of SM identity elements would help identify avenues for future targeted and tailored interventions, improving SM tobacco use disparities and improving SM health.

PI_NAMEs: HINDS, JOSEPHINE TRES (contact)

PROGRAM_OFFICER_NAME: MUJURU, PRISCAH

PROJECT_TERMS: Address;Assessment tool;Behavior;Bisexual;Cardiovascular Diseases;career;career development;Cessation of life;Communities;coping;Coping Behavior;Data;Data Analyses;design;Development;Device or Instrument Development;Dimensions;Disease;Disparity;Doctor of Philosophy;Elements;Etiology;experience;Faculty;Fellowship;Funding;Future;gender minority group;gender minority health research;Goals;Health;Health behavior;health disparity;health disparity populations;Health education;health equity promotion;Heterogeneity;Heterosexuals;high risk;improved;Individual;Intervention;Knowledge;Lesbian;Lesbian Gay Bisexual;life span;Link;Measurable;Measures;meetings;member;Mental Health;Mentors;Mentorship;Methodology;Methods;Minority Groups;minority stress;minority stressor;Modeling;Morbidity - disease rate;mortality;multidisciplinary;National Heart, Lung, and Blood Institute;National Institute on Minority Health and Health Disparities;Nature;Nicotine Dependence;novel;Personal Satisfaction;Persons;Postdoctoral Fellow;primary outcome;Process;professor;promote resilience;protective effect;protective factors;Psychometrics;Research;Research Personnel;Risk;Risk Reduction;Schools;Scientific Advances and Accomplishments;Sexual and Gender Minorities;sexual disparity;sexual minority;sexual minority community;sexual minority group;sexual minority health;Sexuality;Signal Transduction;skills;Smoke;Social Work;Societies;Strategic Planning;Stress;Stress and Coping;stressor;substance use;Surveys;Testing;Texas;Tobacco;tobacco regulatory science;Tobacco use;tool;Training;Uncertainty;United States National Institutes of Health;Universities;Update;Woman;Work;young adult

PROJECT_TITLE: Expanding a culturally relevant model of sexual minority tobacco use: the impact of identity


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Lung Cancer;Mental Health;Prevention;Social Determinants of Health

ORG_CITY: LOS ANGELES

ORG_DEPT: PSYCHOLOGY

ORG_NAME: LOYOLA MARYMOUNT UNIVERSITY

PHR: Project Narrative The number of people in the U.S. living with lung cancer is expected to increase by 25% (from 571,340 to 724,610) in the next decade, and the majority (95%) of lung cancer patients report experiencing lung cancer stigma (i.e., the perception and internalization of negative appraisal from others attributed to one’s lung cancer)—which is associated with adverse psychological and physical health outcomes. There is an urgent unmet public health need to develop psychosocial interventions to reduce lung cancer stigma and improve quality of life for this understudied cancer group. This project will fill a critical gap in the field of cancer control science by adapting an existing patient-focused, self-compassion intervention to target the unique, disease- specific issue of lung cancer stigma, address anticipated delivery challenges, and pilot test the efficacy of the adapted intervention on reducing stigma for lung cancer patients.

PI_NAMEs: WILLIAMSON, TIMOTHY J (contact)

PROGRAM_OFFICER_NAME: FERRER, REBECCA

PROJECT_TERMS: Address;Adult;Anxiety;Area;Attenuated;Basic Behavioral Science;Behavioral;behavioral and social science;Behavioral Research;Behavioral Sciences;Breathing;cancer care;Cancer Control;Cancer Intervention;Cancer Patient;career development;Clinical;Cognition;Compassion;Competence;Data;depressive symptoms;design;Development;Diagnosis;Disease;Disease Progression;Distress;efficacy testing;experience;Feeling;Focus Groups;Future;Goals;Health;Health Sciences;improved;Individual;internalized stigma;Intervention;Interview;Investigation;Link;lung cancer screening;Malignant neoplasm of lung;Malignant Neoplasms;Maps;Measures;Meditation;Memorial Sloan-Kettering Cancer Center;Mental Health;Mentors;Mentorship;Methods;mindfulness;novel;Oncology;Outcome;Participant;patient population;Patients;Perception;Persons;Phase;physical conditioning;pilot test;Population;Positioning Attribute;post intervention;preference;Process;Protocols documentation;psychoeducation;psychologic;psychosocial;Psychosocial Influences;Public Health;Quality of life;randomized, clinical trials;Reaction;Regrets;Reporting;Research;Research Personnel;responders and non-responders;Sampling;screening;secondary outcome;self-compassion;Shame;Site;Smoking;social influence;social science research;social stigma;Source;standard of care;statistics;Stressful Event;Structure;synergism;telehealth;Testing;theories;therapy development;Training;Translating;Translations;understudied cancer;United States National Institutes of Health

PROJECT_TITLE: Adapting and Testing a Novel Self-Compassion Intervention to Reduce Lung Cancer Stigma


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Youth living with HIV (YLHIV) often have difficulty sustaining adherence to daily oral antiretroviral medications, which can lead to poor treatment outcomes and lower quality of life. Long-acting antiretrovirals stand to improve outcomes for YLHIV based on the adherence benefit associated with less-frequent dosing. An improved understanding of biopsychosocial and pharmacologic aspects of their use in youth is essential, and has the potential to enhance durable virologic suppression, lower morbidity and mortality, and lower aggregate community viral load, thus blocking transmission and resulting in greater well-being both for individual youth and for society.

PI_NAMEs: WELD, ETHEL DERBY (contact)

PROGRAM_OFFICER_NAME: HUEBNER, ROBIN E

PROJECT_TERMS: 18 year old;Address;Adherence;Adolescent;Adult;Age Years;aged;AIDS clinical trial group;Anti-Retroviral Agents;assay development;Assessment tool;Award;Awareness;Behavior;Biological Assay;Biometry;biopsychosocial;Blood;brain health;career;Caring;Categories;Characteristics;Clinical;clinical care;Clinical Pharmacology;Clinical Trials;Clinical Trials Network;Cognition;Cognitive;cognitive neuroscience;Cold Chains;Collection;Communicable Diseases;Communities;Data;Decision Making;design;Development;Dose;Drug Kinetics;Drug Monitoring;Dryness;Ensure;executive function;experience;Family;Fingers;Foundations;Frequencies;Funding;Goals;health disparity;Healthcare;HIV;HIV disparities;HIV-infected adolescents;HIV/AIDS;improved;improved outcome;Impulsivity;Individual;Injections;interest;International;International Maternal Pediatric Adolescent AIDS Clinical Trials;Intervention;Intervention Studies;Investigation;Knowledge;Lead;Learning;life span;Link;Lived experience;Matched Group;Measurement;Measures;Mental Depression;Mental disorders;Mental Health;Mentors;Methodology;Methods;Modeling;Morbidity - disease rate;mortality;neurobehavioral;novel;novel therapeutic intervention;novel therapeutics;Oral;Outcome;Participant;pediatric human immunodeficiency virus;Personal Satisfaction;Persons;Pharmaceutical Preparations;Pharmacodynamics;pharmacokinetic model;pharmacologic;Pharmacology;Plasma;Population;Procedures;programs;Property;Psychosocial Assessment and Care;Quality of life;Questionnaires;Research;research clinical testing;Research Personnel;Role;Safety;skills;Social Behavior;social health determinants;Social Network;social stigma;Societies;Source;Spottings;stem;Subgroup;substance use;success;Surveys;Technology;Testing;Therapeutic;Therapeutic Uses;therapy design;tool;Training;transmission blocking;treatment as prevention;treatment group;Treatment outcome;treatment strategy;Viral;Viral Load result;Welding;Youth

PROJECT_TITLE: Optimizing the Use of Long-Acting Antiretrovirals for Youth Living withHIV

STUDY_SECTION: AIDS

STUDY_SECTION_NAME: Acquired Immunodeficiency Syndrome Research Study Section[AIDS]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Lung;Lung Cancer;Prevention;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: CHICAGO

ORG_NAME: RUSH UNIVERSITY MEDICAL CENTER

ORG_STATE: IL

PHR: PROJECT NARRATIVE  Although ‘practice quitting’ is an intuitive first step to engage smokers in the cessation process, there is limited understanding of the best treatment strategies to foster practice quitting. The proposed research will test how practice quitting counseling and nicotine replacement therapy sampling impact potential mediators and smoking cessation attempts. The long-term goal of this line of research is to add to the smoking cessation treatment literature, particularly for smokers not yet ready to quit.

PI_NAMEs: MATHEW, AMANDA R (contact)

PROGRAM_OFFICER_NAME: POSTOW, LISA

PROJECT_TERMS: Abstinence;Accounting;Aftercare;Anxiety Disorders;Attitude;behavior change;Behavioral;Cause of Death;Cessation of life;Chronic;Chronic Care;Chronic Disease;Cigarette;Cigarette Smoker;Cognition;Counseling;design;disability;Distress;emotional symptom;Event;Exercise Therapy;Expectancy;expectation;Fatigue;Fostering;Goals;Head;Health;health management;Health Personnel;Heterogeneity;Hour;Hypertension;Incidence;Individual;Instruction;Intention;Intervention;Intuition;Knowledge;Literature;Mediating;Mediator;Medical Care Costs;Morbidity - disease rate;mortality;Motivation;motivational enhancement therapy;Nicotine;Nicotine Dependence;nicotine exposure;nicotine replacement;Nicotine Withdrawal;novel;optimism;Outcome;Participant;Pathway interactions;Patients;pharmacologic;physical symptom;population health;pressure;Procedures;Process;programs;Randomized;Readiness;recruit;Relapse;Research;Research Design;Resources;Role;Sampling;secondary outcome;Self Direction;Self Efficacy;Severities;Smoke;Smoker;Smoking;smoking cessation;Smoking Cessation Intervention;Testing;therapy development;Time;Tobacco;Tobacco use;Tobacco Use Disorder;treatment effect;treatment program;treatment strategy;United States;willingness;Withdrawal;Withdrawal Symptom

PROJECT_TITLE: A Mechanistic Test of Treatment Strategies to Foster Practice Quitting

STUDY_SECTION: ARM

STUDY_SECTION_NAME: Addiction Risks and Mechanisms Study Section[ARM]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: LONG ISLAND CITY

ORG_NAME: LAGUARDIA COMMUNITY COLLEGE

ORG_STATE: NY

PHR: Project Narrative LaGuardia Community College’s “Bridges to the Baccalaureate Program” provides mentored research experiences year round to qualified minority, economically disadvantaged or disabled students. Beyond the research experience, the program features instructional workshops on quantitative literacy (Biostatistics), oral presentation, research paper critiques, bio- instrumentations, research design, data science, mentoring, leadership and management skills, monthly research student seminars, tutoring, transfer and transfer counseling, student presentations at local and national conferences, instruction in Responsible Conduct of Research, Rigor and Reproducibility and the use of e-Portfolios.

PI_NAMEs: BIKSON, MAROM ;ORTIZ, BENJAMIN D.,;TAJERIAN, MARAL ;TSAI, MIDAS  (contact)

PROGRAM_OFFICER_NAME: STEPANEK, LAURIE ELIZABETH

PROJECT_TERMS: Behavioral Sciences;Biomedical Engineering;Biometry;bridge program;bridge to the baccalaureate;career;Cities;college;community college;Counseling;Critiques;Data Science;design;Development Plans;disabled;disadvantaged background;economic disparity;Educational workshop;Enrollment;experience;Faculty;faculty research;Goals;Grant;Individual;Instruction;Laboratories;Lead;Leadership;Learning;Libraries;Link;Medical center;Mentors;Minority;New York;Paper;posters;Professional counselor;programs;Progress Reports;Pythons;Reporting;Reproducibility;Research;Research Design;Research Project Grants;Research Training;responsible research conduct;Science;Self Management;skills;Students;success;symposium;Training Programs;tutoring;Universities;university student;Wisconsin;Woman;Work

PROJECT_TITLE: "Bridges to the Baccalaureate Research Training Program at LaGuardia Community College"

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - D[TWD-D]


ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE In humans, social processing impairment is a common symptom of several neuropsychiatric disorders, including autism spectrum disorders and schizophrenia. This proposal will employ innovative and precise anatomical, physiological, and causal assays to determine where sensory stimuli are assigned social meaning and how neuromodulators affect the processing of socially meaningful sensory information to drive emotional behavior. This will provide circuit-level insight into how these neuromodulators contribute to social processing impairment in genetic psychiatric mouse models, and aid in the development of novel treatments for psychiatric and mood disorders.

PI_NAMEs: RODRIGUEZ, ERICA J (contact)

PROGRAM_OFFICER_NAME: STOKES, KALYNDA K

PROJECT_TERMS: Affect;Amygdaloid structure;anatomical tracing;Anatomy;Anterior;Area;autism spectrum disorder;Axon;Behavior;Behavioral;behavioral response;Binding;Biological;Biological Assay;cell type;Cells;cingulate cortex;common symptom;Cues;Data;Development;Electrophysiology (science);Emotional;emotional behavior;Emotions;Ethology;excitatory neuron;experimental study;Exposure to;Female;Goals;Human;Image;Impairment;In Situ Hybridization;In Vitro;Individual;innovation;insight;Label;Learning;male;Measures;Mediating;Memory;Mental disorders;Modality;Mood Disorders;motivated behavior;mouse model;Mus;neural;neural circuit;Neural Pathways;Neurobiology;neuromechanism;Neuromodulator;Neurons;Neuropeptides;neuropsychiatric disorder;Noise;novel;Odors;olfactory nuclei;Olfactory Pathways;olfactory stimulus;optogenetics;Oxytocin;Oxytocin Receptor;Phase;Physiological;piriform cortex;Population;Positioning Attribute;presynaptic;Process;programs;Psychiatric therapeutic procedure;psychogenetics;Psychology;Research;Role;Sampling;Schizophrenia;Sensory;sensory stimulus;Shapes;Signal Transduction;skills;Slice;Smell Perception;social;Social Behavior;Social Hierarchy;Social Interaction;Source;Stimulus;Synapses;Synaptic Transmission;Testing;tool;Urine;Vasopressins;Whole-Cell Recordings;Work

PROJECT_TITLE: Dissecting the synaptic and circuit mechanisms underlying olfactory-driven social behavior