NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Genetics;Human Genome;Neurosciences;Rare Diseases

PI_NAMEs: YANG, CHUN ZHANG  (contact)

PROJECT_TERMS: Adopted;alpha ketoglutarate;Base Excision Repairs;Cell Death;Cell Line;Cell membrane;Cell Proliferation;Cell Therapy;Cells;Cellular biology;Chemosensitization;Clathrin-Coated Vesicles;Clustered Regularly Interspaced Short Palindromic Repeats;Cytosine;Cytoskeletal Modeling;cytotoxicity;Data;Dioxygenases;Disease;Disease Outcome;DNA;DNA Damage;DNA Repair;DNA Repair Disorder;DNA Repair Pathway;Endocytic Vesicle;Endocytosis Pathway;Epigenetic Process;Essential Genes;Exhibits;Foundations;functional genomics;Genetic Screening;genome-wide;Genomic approach;Glioma;Guide RNA;homologous recombination;Human;Hypermethylation;improved;inhibitor;Investigation;Investigational Therapies;Isocitrate Dehydrogenase;Knock-out;Lead;Libraries;Malignant Neoplasms;Metabolic Pathway;Modeling;Molecular;Molecular Biology;Molecular Profiling;Molecular Target;Movement;mTOR Inhibitor;mutant;Mutate;Mutation;Nicotinamide adenine dinucleotide;novel;Nutrient;Pathway interactions;Patients;Phagocytes;Phosphorylation;Phosphotransferases;PIK3CG gene;Poly(ADP-ribose) Polymerase Inhibitor;Production;Resistance;RNA library;Role;screening;stem cells;synergism;temozolomide;Tumor Suppression;uptake

PROJECT_TITLE: Chemo-sensitizing IDH1-mutated glioma by molecular targeting


ACTIVITY: ZIA

ADMINISTERING_IC: CA

ARRA_FUNDED: N

FUNDING_MECHANISM: INTRAMURAL RESEARCH

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Immunotherapy

ORG_NAME: DIVISION OF BASIC SCIENCES - NCI

PI_NAMEs: ROCHE, PAUL  (contact)

PROJECT_TERMS: Antigen-Presenting Cells;Antigens;Binding;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cell Physiology;Data;Defect;Dendritic Cells;draining lymph node;functional status;Goals;Immune system;In Vitro;in vivo;lymph nodes;Malignant Neoplasms;Molecular;Mus;neoplastic cell;novel;Peptides;prevent;Solid Neoplasm;subcutaneous;tumor;tumor microenvironment

PROJECT_TITLE: Dysregulation of Antigen Presenting Cell Function in Cancer


NIH_SPENDING_CATS: Cancer;Genetics;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

PI_NAMEs: SINGER, DINAH S. (contact)

PROJECT_TERMS: Acetyltransferase;Apoptosis;Architecture;Autoantigens;autoreactivity;Blood Cells;Bone Marrow;Bromodomain;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Compartmentation;Cell Count;Cell Physiology;Cell Proliferation;Cell surface;Cells;chemokine;chemokine receptor;Chromatin;Chromatin Structure;Coculture Techniques;Defect;Development;Developmental Process;DNA Polymerase II;DNA Repair;Emigrations;epigenetic regulation;Epithelial Cells;Epithelium;Family;Frequencies;Gene Expression Regulation;Generations;Genes;Genetic Transcription;Goals;hematopoietic differentiation;Human;in vivo;Intestines;Ligands;Maintenance;Mesenchymal;Monitor;Mus;Organ;Pathway interactions;Peptides;Peripheral;Phenotype;Phosphorylation;Phosphotransferases;Play;Population;Process;Productivity;progenitor;Proliferating;Proteins;Regulatory T-Lymphocyte;Role;Series;single-cell RNA sequencing;skin hyperplasia;stem cells;Structure of thymic cortex;Surface;T-Cell Receptor;TAF7 gene;Thymic epithelial cell;thymocyte;Thymus Gland;Transcription Elongation;transcription factor;Transcription Initiation;Winged Helix

PROJECT_TITLE: In vivo function of BRD4


NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics

PI_NAMEs: BROGNARD, JOHN  (contact)

PROJECT_TERMS: Alleles;Biochemical;Bioinformatics;Biological Assay;BRAF gene;cancer genomics;Communities;Cultured Cells;Dependence;Development;driver mutation;drug development;Evaluation;functional genomics;functional restoration;Genetic;genome editing;Genomic approach;Goals;Human;in vivo;Knowledge;loss of function;loss of function mutation;Malignant Neoplasms;Molecular;Monitor;mutant;Mutation;novel;Oncogenic;Pathway interactions;Patients;Phenotype;Phosphotransferases;Pongidae;Process;Research;response;Small Interfering RNA;Somatic Mutation;targeted treatment;tumor;tumorigenesis

PROJECT_TITLE: Novel Tumor Suppressing Kinases in Cancer


NIH_SPENDING_CATS: Biotechnology;Cancer;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Orphan Drug;Rare Diseases

PROJECT_TERMS: anti-cancer research;Antibodies;Antibody-drug conjugates;cancer cell;Cancer Patient;Cell Survival;Colorectal Cancer;Development;Goals;Head and Neck Cancer;Head and Neck Squamous Cell Carcinoma;inhibitor;lung tumorigenesis;Malignant Breast Neoplasm;Malignant neoplasm of esophagus;Malignant neoplasm of ovary;Malignant Neoplasms;Modality;Molecular;novel;novel therapeutics;Oncogenic;Phosphotransferases;Play;precision drugs;Role;Squamous cell carcinoma;targeted treatment;Therapeutic Intervention;tumorigenesis

PROJECT_TITLE: Oncogenic Kinases in Cancer


NIH_SPENDING_CATS: Cancer;Clinical Research;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

PI_NAMEs: LEBLANC, AMY  (contact)

PROJECT_TERMS: Address;Adjuvant;Adolescent;Adult;Age;anti-cancer research;Antineoplastic Agents;Area;arm;assay development;Biological;Biological Assay;Biological Markers;Biological Models;Biological Specimen Banks;Biology;Brain Neoplasms;Cancer Biology;cancer clinical trial;Cancer Model;Cancer Patient;cancer type;Canis familiaris;Characteristics;Child;Childhood;Childhood Osteosarcoma;Clinical;clinical application;Clinical Trials;cohort;Companions;comparative;Comparative Study;Complex;Conduct Clinical Trials;Data;design;Development Plans;Disease;Distant;dog genome;drug development;druggable target;Fluorescent in Situ Hybridization;Future;Gene Expression;Gene Expression Profile;Genomics;Goals;Growth;Human;Human Cell Line;human data;improved;improved outcome;In Vitro;in vivo;Infrastructure;Inherited;Investigation;Kidney;Knowledge;Laboratories;laboratory experiment;Liver;Lung;Lymphoid;Malignant Bone Neoplasm;Malignant Neoplasms;Metastatic Neoplasm to the Lung;Mission;Modeling;Molecular;Multi-Institutional Clinical Trial;Mus;nano-string;Natural History;Neoplasm Metastasis;Normal tissue morphology;novel therapeutic intervention;novel therapeutics;oncology program;oncology trial;Osteosarcoma;Patients;Pediatric Neoplasm;Pharmaceutical Preparations;Positioning Attribute;Pre-Clinical Model;Preclinical Drug Development;Primary Neoplasm;prognostic;prognostic value;programs;Publishing;Puma;Reagent;Research Design;Resource Development;Sampling;Sirolimus;Site;standard of care;success;Techniques;therapeutic target;Tissues;Translating;translation to humans;treatment response;tumor;Tumor Tissue;Work

PROJECT_TITLE: Comparative Oncology Program Laboratory


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Neurosciences;Orphan Drug;Prevention;Rare Diseases

PROJECT_TERMS: Adult;Affect;Ally;American;Astrocytoma;Basic Science;Biopsy;Brain Neoplasms;Breeding;Canis familiaris;Catalogs;CCR;Central Nervous System;Characteristics;Clinical;Clinical Trials;Collaborations;college;Companions;comparative;Data;Development;Diagnosis;Discipline;Disease;disease natural history;drug development;drug discovery;Early Diagnosis;Event;Excision;experience;Extramural Activities;Face;Funding;Future;Glioma;Goals;Grant;Group Structure;Histologic;Histology;Human;human disease;human model;Image;Immunotherapeutic agent;improved;improved outcome;Incidence;Income;Infrastructure;Internal Medicine;irradiation;Journals;Knowledge;Malignant Childhood Neoplasm;Malignant neoplasm of brain;Malignant Neoplasms;Medicine;meetings;member;meningioma;Modeling;Molecular;Morbidity - disease rate;National Center for Advancing Translational Sciences;neuro-oncology;Neurology;neuropathology;novel;oligodendroglioma;Oncology;oncology program;Operative Surgical Procedures;Outcome;Paper;Pathology;Patient Care;Patients;Pennsylvania;Pituitary Neoplasms;Play;Pre-Clinical Model;Prevention;Procedures;Publishing;Research;Research Personnel;Role;Specialist;statistics;Time;Training;transcriptome sequencing;tumor;United States National Institutes of Health;Universities;Veterinarians;Veterinary Medicine;Work;working group

PROJECT_TITLE: Comparative Brain Tumor Consortium


PI_NAMEs: KEARNEY, MARY  (contact)

PROJECT_TERMS: 5' Untranslated Regions;Address;animation;antiretroviral therapy;Binding;Biological Assay;Biological Process;Blood;Case Study;Cell Fraction;Cell Proliferation;Cell Separation;Cells;Clonal Expansion;Clone Cells;Code;Collecting Cell;CpG Islands;Data;Deamination;digital;DNA;DNA Methylation;env Genes;Epigenetic Process;epigenetic silencing;EZH2 gene;follow-up;Frequencies;Genes;Genetic Determinism;Genetic Transcription;Genome;genome sequencing;Guanine;Histone H3;HIV;HIV Infections;HIV-1;Immune;Immune response;In Vitro;in vivo;Individual;innovation;Interruption;Intervention;Investments;Laboratories;lymph nodes;Lysine;Manuscripts;Measures;member;Methods;Methylation;Multi-Drug Resistance;Natural Killer Cells;Nucleosomes;Opportunistic Infections;Patients;Peripheral Blood Mononuclear Cell;Persons;Plasma;Population;Preparation;prevent;Proliferating;promoter;Provirus Integration;Proviruses;Publications;Publishing;recruit;Reporting;Repressor Proteins;Research;resistance mutation;response;Rest;Retroviridae Infections;Reverse Transcription;RNA;RNA Splicing;Role;Sampling;Science;Site;Sorting;Source;Sulfate;symposium;T memory cell;T-Cell Activation;T-Lymphocyte;T-Lymphocyte Subsets;Technology;Testing;Time;Tissues;transcription factor;Transcription Initiation Site;Variant;viral fitness;Viremia;Virus;virus genetics;Virus Latency;Work

PROJECT_TITLE: Effects of Antiretroviral Therapy on Transcriptional Activity of HIV Proviruses


PROJECT_TERMS: acute infection;Address;Aftercare;anti-PD-1;antiretroviral therapy;Biological Assay;Cell Fraction;cell killing;Cell Proliferation;Cells;Child;Clonal Expansion;Clone Cells;Collaborations;curative treatments;Cytotoxic T-Lymphocytes;cytotoxicity;Data;Disease remission;Dose;efficacy evaluation;Emodin;Event;Future;Genes;Genetic;Genetic Transcription;Genome;Heterogeneity;Histone Deacetylase Inhibitor;HIV;HIV Infections;HIV-1;Immune;Immune checkpoint inhibitor;improved;In Vitro;in vivo;Individual;Infection;Infusion procedures;inhibitor;insight;integration site;Intervention;Investments;lymph nodes;Maintenance;Manuscripts;Measures;Methods;Minor;Modification;National Institute of Allergy and Infectious Disease;Nature;neutralizing antibody;neutralizing monoclonal antibodies;new technology;North Carolina;Oncogenes;Opportunistic Infections;Participant;Patients;peripheral blood;Peripheral Blood Mononuclear Cell;Population;pressure;Production;Proliferating;Proviruses;Publications;Reporting;Research;Resistance;response;Retroviridae Infections;RNA;Sampling;Structure;symposium;T memory cell;T-Lymphocyte;Technology;Tissues;Universities;Viral;Virus;Vorinostat;Zinc Fingers

PROJECT_TITLE: Impact of Interventions on Clonally Expanded Proviruses and Their RNA Expression


NIH_SPENDING_CATS: Antimicrobial Resistance;Biotechnology;Cancer;Cancer Genomics;Genetics;HIV/AIDS;Human Genome;Infectious Diseases;Pediatric;Pediatric - AIDS

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Acute;acute infection;Adherence;Affect;AIDS clinical trial group;Anti-Retroviral Agents;Anti-retroviral resistance;antiretroviral therapy;Binding;bioinformatics pipeline;Biological Assay;Cells;Clinical;Collaborations;cost;Data;Data Set;design;Drug resistance;drug resistance development;Enrollment;env Genes;Evolution;experimental study;Failure;Far East;Frequencies;Genes;Genetic;Genetic Recombination;Genome;genome sequencing;Genotype;Hawaii;high risk population;HIV;HIV drug resistance;HIV Envelope Protein gp120;HIV Genome;HIV Infections;improved;In Vitro;in vivo;Individual;Infection;insight;Integrase;integration site;Interruption;Length;Libraries;Link;Manuscripts;Medical;Minority;Multi-Drug Resistance;Mutation;nanopore;next generation;next generation sequencing;off-target mutation;Opportunistic Infections;Participant;Pattern;Pharmaceutical Preparations;Phylogenetic Analysis;Plasma;Population;Population Dynamics;pre-exposure prophylaxis;pressure;prevent;programs;Proviruses;Publications;rare variant;Recombinants;Red Cross;Regimen;Reporting;Research;Research Institute;Resistance;resistance mutation;response;Rest;Retroviridae Infections;Retrovirology;Role;Sampling;Science;Structure;symposium;Techniques;Technology;Thailand;transmission process;Variant;Viral;Viral Genome;Viremia;Virion;virtual;Virus

PROJECT_TITLE: Ultrasensitive Single-Genome Sequencing to Study HIV Transmission and Evolution


PI_NAMEs: CAPLEN, NATASHA  (contact)

PROJECT_TERMS: Address;Affinity;Area;Binding;Biochemical;Biological Assay;biophysical properties;Bone Tissue;Cancer Biology;cancer cell;cancer therapy;Categories;Cell Line;Cell membrane;Cell Physiology;Cell Survival;Cells;Chimeric Proteins;Chromosomes;Clinical;clinically relevant;cohort;combinatorial;comparison control;CRISPR-mediated transcriptional activation;Cytotoxic Chemotherapy;Data;defined contribution;Dependence;design;Desmoplastic;Detection;Development;Disease;Disease Progression;Distant;DNA;DNA Polymerase II;Dreams;ETS1 gene;Evaluation;Event;Ewings sarcoma;EWSR1 gene;Exclusion;Exhibits;Exons;Exposure to;F-Actin;FLI1 gene;FLI1 Transcription Factor;Focal Adhesions;Follow-Up Studies;Functional disorder;functional genomics;fusion gene;Fusion Oncogene Proteins;Future;G-Quartets;gene discovery;Gene Expression;Gene Expression Regulation;Genes;Genetic;Genetic Transcription;genome-wide;Growth;Guanine;Health;Heterogeneous-Nuclear Ribonucleoproteins;Human Chromosomes;Image;improved outcome;Individual;Introns;Investigation;Investigational Drugs;Knowledge;Life;liposarcoma;loss of function;Malignant Bone Neoplasm;Malignant Neoplasms;Mediating;Messenger RNA;Molecular Carcinogenesis;Molecular Target;Movement;mRNA Precursor;Mutation;Neoplasm Metastasis;Neoplasms;neoplastic cell;Neural Crest Cell;new therapeutic target;novel therapeutic intervention;Nucleic Acid Binding;nucleic acid binding protein;Nucleic Acids;Nucleoplasm;Oncogene Deregulation;Oncogenes;Oncogenic;Operative Surgical Procedures;Pathway interactions;Patient-Focused Outcomes;Patients;Pharmacotherapy;Phenotype;Phosphorylation;Physical condensation;Post-Transcriptional Regulation;Post-Translational Regulation;posttranscriptional;Process;progenitor;Proliferating;Promoter Regions;Property;Protein Family;protein function;Proteins;Publishing;Radiation;recruit;Refractory;Regulation;Relapse;Reporting;Repression;Research;Resolution;response;Reverse Transcription;Risk;RNA;RNA Binding;RNA Interference;RNA interference screen;RNA metabolism;RNA Processing;RNA Splicing;RNA Transport;Sarcoma;scaffold;Series;Signal Transduction;Site;Small RNA;soft tissue;standard care;Stimulus;Structure;superresolution microscopy;Survival Rate;TAF15 gene;Technology;Transcript;transcription factor;Transcriptional Regulation;transcriptome;Translations;Translocation Breakpoint;treatment response;tumor;Tumor Biology;tumorigenesis;Up-Regulation;Variant;Vinculin;Visualization;Work

PROJECT_TITLE: Discovery of genes required for expression or activity of fusion oncogenes


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Genetics;Rare Diseases

PI_NAMEs: LARION, MIOARA  (contact)

PROJECT_TERMS: Biological Assay;Biological Models;Cell Culture Techniques;Cell Line;Cells;DNA Methylation;established cell line;Glioma;Goals;histone methylation;In Vitro;in vivo;Mass Spectrum Analysis;Metabolic;Modeling;mouse model;Mus;Mutate;Mutation;Phenotype;protein expression;Research;Testing;Therapeutic;Therapeutic Effect;tumor;Western Blotting

PROJECT_TITLE: The effect of therapeutics on mutated IDH1 cell lines and mice tumor models


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Neurosciences;Rare Diseases

PROJECT_TERMS: Apoptosis;Cell Death;Cell Death Induction;Cell Line;Cell Proliferation;Ceramides;Cholesterol;Cholesterol Homeostasis;Collaborations;combinatorial;Defect;Drug Combinations;efficacy evaluation;Enzymes;Equilibrium;established cell line;Fatty Acids;galactosylgalactosylglucosylceramidase;Glioma;Goals;Human;in vivo;Lead;Link;Metabolic;Metabolism;metabolomics;mouse model;Mus;Mutate;Mutation;oligodendroglioma;Running;Sampling;site-1 protease;Sphingolipids;Sphingosine;SPHK1 enzyme;Tissue Sample;tumor;Xenograft procedure

PROJECT_TITLE: Targeted and untargeted metabolomics in IDH1 mutated xenografts in mice


NIH_SPENDING_CATS: Cancer;Neurosciences

PROJECT_TERMS: Biological Markers;Blood;Cerebrospinal Fluid;Data;Diagnosis;Disease remission;Measures;mutant;Patient Monitoring;Patients;Prognosis;Reporting;Sampling;Statistical Data Interpretation;Time;Tissues;treatment response;Urine

PROJECT_TITLE: Metabolite profiling of patients blood, urine, cerebrospinal fluid and tissue


NIH_SPENDING_CATS: Cancer

PROJECT_TERMS: Brain;Clinical;Disease Progression;Glucose;Glutamine;In Vitro;in vivo;Label;Magnetic Resonance Imaging;Measures;Metabolic;mouse model;Mus;Normal Cell;Pathway interactions;pre-clinical;Source;tumor

PROJECT_TITLE: In vivo and in vitro metabolic flux analysis in preclinical mouse models


NIH_SPENDING_CATS: Bioengineering;Brain Cancer;Brain Disorders;Cancer;Machine Learning and Artificial Intelligence;Rare Diseases

PROJECT_TERMS: Biological;Brain Neoplasms;Cell Line;Cells;Cholesterol Esters;Classification;Collaborations;Databases;DNA;Endoplasmic Reticulum;Fatty Acids;Finland;Goals;improved;In Situ;in vivo;Incubators;inhibitor;Ions;Lipids;Machine Learning;Metabolic;Metabolism;Methodology;Methods;Microscopy;new technology;novel;oligodendroglioma;Organelles;Patients;Phospholipids;Proteins;Raman Spectrum Analysis;Resolution;RNA;Site;Slide;Tissues;tumor;tumor microenvironment;Universities;Visualization

PROJECT_TITLE: Develop RAMAN imaging to visualize metabolism in cell lines and tissue


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Immunization;Immunotherapy;Neurosciences;Orphan Drug;Rare Diseases;Vaccine Related

PI_NAMEs: GILBERT, MARK  (contact)

PROJECT_TERMS: Adjuvant Therapy;Adrenal Cortex Hormones;Adult;Basic Science;Biology;Blood;Blood - brain barrier anatomy;Blood specimen;brain based;Brain Neoplasms;cancer immunotherapy;cancer therapy;Cells;checkpoint inhibition;clinical center;Clinical Trials;Collaborations;Complex;Correlative Study;design;efficacy evaluation;Epigenetic Process;Exhibits;Face;fighting;Foundations;Functional disorder;Future;Glioblastoma;gliosarcoma;Goals;Heat shock proteins;Hematologic Neoplasms;Hypoxia;Iatrogenesis;Immune;Immune checkpoint inhibitor;Immune Evasion;immune function;Immune response;Immune system;Immunologic Monitoring;Immunologics;Immunology;immunoregulation;Immunosuppression;Immunotherapeutic agent;Immunotherapy;Impairment;improved;improved outcome;in vivo;ipilimumab;Laboratories;Lymphocyte;Lymphocyte Function;Lymphopenia;Malignant neoplasm of central nervous system;Malignant Neoplasms;Metabolic;Molecular;Multi-Institutional Clinical Trial;Natural Immunity;neoantigens;neoplastic cell;Newly Diagnosed;Nivolumab;novel;Oncology;participant enrollment;Patients;pembrolizumab;Peptides;peripheral blood;Persons;phase II trial;Play;Predisposition;prevent;Primary Brain Neoplasms;Process;programmed cell death protein 1;programs;Proteins;Radiation therapy;Randomized;randomized, clinical trials;Regimen;Regulatory T-Lymphocyte;Research Personnel;response;Role;Running;sample collection;Sampling;Seminal;Silent Mutation;Solid;T-Lymphocyte;temozolomide;Tissues;Toxic effect;trafficking;translational immunology;Translational Research;treatment response;tumor;tumor microenvironment;Tumor-associated macrophages;United States National Institutes of Health;Vaccines;Work

PROJECT_TITLE: Translational Immunology


PI_NAMEs: ASHWELL, JONATHAN  (contact)

PROJECT_TERMS: Actins;Acute Graft Versus Host Disease;adaptive immune response;Calcineurin;Calcineurin inhibitor;Complex;Complication;confocal imaging;CRISPR/Cas technology;Cyclosporine;Cytoskeleton;Defect;Distal;Effectiveness;Event;Family;Genes;Human;Immune response;Immunity;Impairment;Jurkat Cells;knock-down;Knock-out;Ligands;Ligation;Lymphocyte-Specific p56LCK Tyrosine Protein Kinase;Mediating;mutant;nuclear factors of activated T-cells;Peptides;Phenotype;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphotransferases;PPP3CA gene;Process;Protein Dephosphorylation;Protein Isoforms;Protein Tyrosine Kinase;Receptor Signaling;reconstitution;recruit;Role;Series;Serine;Signal Transduction;Signaling Molecule;Small Interfering RNA;Structure;T-Cell Activation;T-Cell Receptor;T-Lymphocyte;Threonine;Tissue Transplantation;ZAP-70 Gene

PROJECT_TITLE: T cell receptor proximal signaling


NIH_SPENDING_CATS: Aging;Brain Disorders;Breast Cancer;Cancer;Neurosciences;Women's Health Research

PI_NAMEs: STEEG, PATRICIA SCHRIVER (contact)

PROJECT_TERMS: African American;Age;Age disparity;age related;aggressive breast cancer;Biological Assay;Biological Models;Brain;brain tissue;Breast Cancer Patient;Data;Development;Disease;Disseminated Malignant Neoplasm;DNA Sequence Alteration;Environment;Harvest;Hematogenous;Histology;Immunoblot Analysis;In Vitro;Infiltration;Inflammation;insight;Lasers;Macrophage;Malignant Breast Neoplasm;Malignant neoplasm of brain;Mammary Neoplasms;Mass Spectrum Analysis;Metabolism;Metastatic malignant neoplasm to brain;Microdissection;migration;Modeling;Multivariate Analysis;Mus;Mutation;Neoplasm Metastasis;neurotransmission;Outcome;Pathway Analysis;Patients;Phenotype;primary endpoint;Proteins;Proteomics;Resolution;Side;Signal Pathway;Tenascin;Testing;The Cancer Genome Atlas;triple-negative invasive breast carcinoma;tumor;Tumor Cell Migration;tumorigenesis;Woman;wound healing;young woman

PROJECT_TITLE: Breast cancer aggressiveness in young patients


NIH_SPENDING_CATS: Cancer;HIV/AIDS;Infectious Diseases

PI_NAMEs: FREED, ERIC  (contact)

PROJECT_TERMS: antiretroviral therapy;Binding;Capsid Proteins;Cell membrane;Cell surface;Cells;Cellular biology;Complex;Destinations;Development;env Gene Products;Enzymes;gene product;Glycoproteins;Goals;HIV;HIV-1;HIV-2;inhibitor;Inositol;insight;Integration Host Factors;interest;Interferons;Molecular;Natural Immunity;nef Protein;novel;P-selectin ligand protein;particle;Pathway interactions;Phosphatidylinositols;Play;polyanion;protein function;Proteins;Research;Role;Site;SIV;Sphingomyelinase;structural determinants;trafficking;Viral;Virion;Virus;Virus Assembly;vpu Protein;Work

PROJECT_TITLE: Gag Trafficking, Assembly, and Release


NIH_SPENDING_CATS: Cancer;HIV/AIDS

PROJECT_TERMS: antagonist;Anti-retroviral drug resistance;antiretroviral therapy;Binding Proteins;Cell membrane;cell type;Cells;Cellular biology;Complex;Cryoelectron Microscopy;Cytoplasmic Tail;Data;Defect;Development;Drug resistance;Elements;Future;Glycoproteins;glycosylation;Goals;guanylate;HIV;HIV-1;Human;Impairment;in vivo;inhibitor;Integrase;Integration Host Factors;interest;Maps;Mediating;Modification;Molecular;Molecular Conformation;Monkeys;Mutation;Natural Immunity;novel;particle;Pathway interactions;Play;Point Mutation;Process;Proteins;recruit;Research;Retroviridae;Role;Signal Transduction;SIV;Structure;trafficking;ubiquitin-protein ligase;Viral;Virion;Virus;Work

PROJECT_TITLE: Envelope Glycoprotein Incorporation and Function


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Orphan Drug;Pediatric;Pediatric Cancer;Precision Medicine;Rare Diseases

PI_NAMEs: SHERN, JOHN  (contact)

PROJECT_TERMS: Adolescent;aggressive therapy;Biological Assay;Biological Models;Cells;chemotherapy;Chemotherapy and/or radiation;Child;Childhood;childhood sarcoma;Childhood Soft Tissue Sarcoma;Chromatin;Chromatin Structure;clinical translation;Clinical Trials;Clinical Trials Cooperative Group;Collaborations;Combined Modality Therapy;Complex;cyclin C;Cyclin-Dependent Kinases;Cyclins;Data;Diagnosis;Disease;disorder subtype;DNA-Directed RNA Polymerase;Drug Combinations;Epigenetic Process;Folic Acid Antagonists;FOXO1A gene;functional genomics;Funding;Gene Expression Regulation;gene repression;Genes;Genetic;Genetic Transcription;Genomics;Goals;high risk;high risk population;high-throughput drug screening;Histologic;inhibitor;insight;Knowledge;Malignant Neoplasms;Measures;Mediator;Metabolic stress;Methods;Molecular;molecular subtypes;Morbidity - disease rate;mortality;mutant;Mutation;National Center for Advancing Translational Sciences;neoplastic cell;Neurofibrosarcoma;novel therapeutics;Oncogenes;Operative Surgical Procedures;Pathway interactions;patient stratification;Patients;PAX3 gene;Pediatric Oncology Group;peripheral blood;permissiveness;Phosphorylation;Phosphotransferases;PIK3CA gene;PIK3CG gene;Point Mutation;Pre-Clinical Model;precision oncology;Preclinical Testing;Prognosis;prognostic tool;prognostication;programs;Radiation;Regimen;Relapse;relapse risk;response;Rhabdomyosarcoma;risk stratification;Sampling;Sarcoma;Signal Transduction;Soft tissue sarcoma;synergism;targeted treatment;Techniques;Testing;therapy development;Time;tool;Topoisomerase;Transcriptional Activation;Translating;Treatment Protocols;tumor;United States;Up-Regulation;Work;Xenograft Model

PROJECT_TITLE: Genomic characterization and development of therapies for pediatric sarcoma


NIH_SPENDING_CATS: Cancer;Clinical Research;Immunotherapy

PI_NAMEs: ALTAN-BONNET, GREGOIRE  (contact)

PROJECT_TERMS: antagonist;Antigens;Biochemical;Biology;cancer immunotherapy;CD8B1 gene;Cells;Collaborations;Communication;Computer Models;Development;Differential Equation;digital;Discrimination;Down-Regulation;Feedback;Goals;Heterogeneity;human model;immune activation;Immune response;Immunotherapy;Inflammatory Response;Lead;Leukocytes;Ligands;Lymphocyte;Methodology;Modeling;mouse model;Nature;novel;Phase;phenomenological models;Phenotype;Phosphoric Monoester Hydrolases;Phosphotransferases;Population;Proteins;Protocols documentation;Provider;PTPN6 gene;receptor;Regulation;response;Science;Signal Transduction;single cell analysis;small molecule inhibitor;Sorting;Specificity;Speed;T-Cell Activation;T-Lymphocyte;Testing;Theoretical model;tumor;tumor eradication;Validation

PROJECT_TITLE: Phenotypic variability within isogenic population of lymphocytes


NIH_SPENDING_CATS: Cancer;Genetics

PI_NAMEs: LUO, JI  (contact)

PROJECT_TERMS: Anchorage-Independent Growth;Attention;cancer cell;Cancer cell line;Cancer Patient;Cells;Clinical Trials;Colorectal;Colorectal Cancer;Combined Modality Therapy;CRISPR/Cas technology;Dependence;Development;driver mutation;Drug Combinations;Drug resistance;Drug Targeting;Drug toxicity;Epithelial Cells;functional genomics;Genes;Genetic;Genetic Transcription;Goals;high-throughput drug screening;improved;in vivo;inhibitor;kinase inhibitor;KRAS2 gene;Libraries;loss of function;Lung;Malignant neoplasm of lung;Malignant neoplasm of pancreas;Malignant Neoplasms;MAP Kinase Gene;MEKs;Modality;Modeling;Multiple Myeloma;Mus;mutant;new therapeutic target;novel therapeutics;oncogene addiction;Oncogenes;Oncogenic;Pancreas;Pathway interactions;Patients;pharmacologic;PIK3CG gene;posttranscriptional;Pre-Clinical Model;prevent;ras Oncogene;Resistance;resistance mechanism;response;Signal Transduction;small molecule inhibitor;Stress;targeted treatment;Therapeutic;tool;treatment response;tumor;Xenograft procedure

PROJECT_TITLE: Target discovery and combination therapy in KRAS mutant cancer


NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics;Lung;Lung Cancer;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

PROJECT_TERMS: 3-Dimensional;Adoption;Affect;Alveolar;Alveolar Cell;Biology;cancer cell;Cancer cell line;Carcinoma;cell behavior;Cell Culture Techniques;cell growth;Cell model;Cell Survival;Cells;cost;Development;Dissection;Epithelial Cells;Epithelium;Exhibits;Gene Expression;Genetic;Goals;Growth;Human;In Vitro;in vitro Model;in vivo;KRAS2 gene;Lung;Lung Adenocarcinoma;lung cancer cell;Malignant Neoplasms;metaplastic cell transformation;Methods;Microscope;Modeling;Molecular;monolayer;Mus;mutant;neoplastic cell;Oncogenes;Oncogenic;Organoids;Phenotype;scale up;Signal Transduction;spheroids;stem cells;stemness;Surface;System;targeted treatment;transplant model;tumor;tumor behavior;Xenograft procedure

PROJECT_TITLE: Organoid models of KRAS mutant cancer


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Neurosciences;Pediatric;Pediatric Cancer;Precision Medicine;Rare Diseases

PROJECT_TERMS: Affect;Atlases;Benign;Biological Assay;Biological Models;Blood;cell free DNA;Cell Surface Proteins;cell type;Cells;Childhood Solid Neoplasm;Chromatin;Clinical;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;Combined Modality Therapy;Complex;Data;design;Development;Disease;Disease Progression;Dissection;DNA;DNA sequencing;Early Diagnosis;Early treatment;Emerging Technologies;Engineering;Epigenetic Process;evidence base;FOXO1A gene;Genes;Genetic;Genetic Heterogeneity;Genetic Transcription;genome sequencing;genomic data;Genomics;Goals;Heterogeneity;improved;in vivo Model;Intervention;Legal patent;loss of function mutation;Malignant - descriptor;malignant state;member;Methods;Natural History;neoplastic cell;Nerve;NF1 gene;Patients;PAX3 gene;Pediatric Neoplasm;Plasma;Polycomb;Population;pressure;programs;Proteins;Proteomics;radiological imaging;Refractory Disease;Relapse;resistance mechanism;Rhabdomyosarcoma;Sampling;Schwann Cells;screening;single cell sequencing;small molecule;Specimen;Technology;Therapeutic;therapeutic target;therapy resistant;Transcription Repressor;Transcriptional Activation;Translations;tumor;tumor DNA;tumor heterogeneity;tumor progression;whole genome;Work

PROJECT_TITLE: Genomic dissection of tumor heterogeneity and progression


NIH_SPENDING_CATS: Biotechnology;Cancer;Gene Therapy;Genetics;Immunotherapy;Lung;Lung Cancer;Precision Medicine

PI_NAMEs: SHARAN, SHYAM  (contact)

PROJECT_TERMS: Animals;anti-cancer;Antineoplastic Agents;Biological Markers;Biomedical Engineering;Biopsy;cancer cell;Cancer Model;CAR T cell therapy;Categories;CD276 gene;Cells;chimeric antigen receptor T cells;Clinical;clinical translation;clinical trial protocol;clinically relevant;cohort;Collaborations;Collection;comparative;Disease Progression;Disease Resistance;drug efficacy;Drug Targeting;efficacy evaluation;efficacy study;Eligibility Determination;Enrollment;Epidermal Growth Factor Receptor;Evaluation;Evaluation Studies;Flow Cytometry;Formulation;Frequencies;Generations;Genetic Engineering;Genetically Engineered Mouse;Histopathology;Image;Immunocompromised Host;inhibitor;Integral Membrane Protein;Laboratories;Lung Neoplasms;Malignant neoplasm of lung;Malignant Neoplasms;Methods;Modeling;Molecular;Molecular Abnormality;molecular subtypes;mouse model;Mutagenesis;Non-Small-Cell Lung Carcinoma;novel;novel therapeutics;Oligonucleotides;Oncogenic;patient derived xenograft model;Patient Representative;Patients;Pattern;Pharmaceutical Preparations;Pharmacodynamics;pharmacokinetics and pharmacodynamics;Platinum;pre-clinical;preclinical development;preclinical evaluation;Prediction of Response to Therapy;programs;Publications;Recording of previous events;Recurrence;Regimen;Research Personnel;Resistance;response;Retinoblastoma Protein;RNA Polymerase II;small cell lung carcinoma;Surface Antigens;targeted treatment;Techniques;Therapeutic;therapeutic development;therapeutic evaluation;Tissues;Topoisomerase;transcriptome;treatment response;tumor;Work

PROJECT_TITLE: Preclinical Development of Therapeutics in Murine Models of Lung Cancer


NIH_SPENDING_CATS: Breast Cancer;Cancer;Genetics;Orphan Drug;Ovarian Cancer;Rare Diseases;Women's Health Research

PROJECT_TERMS: Address;Aftercare;Agonist;Alleles;Allografting;animal colony;Animals;anti-cancer;arm;Automobile Driving;BRCA1 gene;BRCA2 gene;Breast Cancer Model;Camptothecin;cancer cell;cancer subtypes;cancer vaccination;CCR;CDK4 gene;Circulation;Cisplatin;Classification;Clinical;Clinical Data;clinical development;clinical subtypes;clinically relevant;cohort;Collaborations;Collection;Combined Modality Therapy;comparative;Data;design;Development;Division of Cancer Prevention;Dose;drug efficacy;Drug Evaluation;efficacy testing;Epithelial Cells;Epithelial ovarian cancer;Epithelium;Evaluation;experimental arm;experimental study;Extramural Activities;Formulation;Funding;Genetic;Genetically Engineered Mouse;genomic aberrations;Histologic;hormone receptor-positive;hormone sensitivity;hormone therapy;Human;human disease;in vivo;inhibitor;irinotecan;Laboratories;Malignant Breast Neoplasm;Malignant neoplasm of ovary;Malignant Neoplasms;Mammalian Oviducts;Mammary gland;Modality;Modeling;Molecular;Molecular Profiling;mouse model;Mus;mutant;Mutation;novel;Oncogenic;Outcome;Ovarian;ovarian neoplasm;Pathway interactions;Patients;Pharmaceutical Preparations;Pharmacodynamics;Placebos;Poly(ADP-ribose) Polymerase Inhibitor;pre-clinical;pre-clinical assessment;pre-clinical research;preclinical evaluation;Preclinical Testing;Preparation;Preventive;Process;programs;protein biomarkers;Protein Family;Publishing;Reaction;Refractory;Research;Research Personnel;Resistance;response;Retinoblastoma Protein;Sampling;Schedule;Series;Serous;Skin;standard of care;System;The Cancer Genome Atlas;Therapeutic;therapeutic development;therapeutic evaluation;Therapeutic Intervention;therapy resistant;tool;Topoisomerase-I Inhibitor;Toxic effect;TP53 gene;Treatment Efficacy;tumor;tumor progression;Tumor Tissue

PROJECT_TITLE: Therapeutic evaluation in ovarian and breast cancer GEM-GDA models


PROJECT_TERMS: Adjuvant;Allografting;Anatomy;Animals;anti-CTLA4 antibodies;anti-PD-1;anti-PD-L1 antibodies;anti-PD-L1 therapy;anti-PD1 therapy;Antibodies;Antitumor Response;Apoptosis;Biocompatible Materials;Biological;Biological Markers;biomarker evaluation;Biotechnology;BRAF gene;Cancer Vaccines;CDK4 gene;Characteristics;checkpoint therapy;Chemosensitization;Clinical;Clinical Management;clinically relevant;cohort;Collaborations;Complex;Cooperative Research and Development Agreement;Cutaneous Melanoma;cytokine;Data;Devices;Disease;disease model;Drug Combinations;drug development;efficacy evaluation;Engineering;Evaluation;Evaluation Research;Excision;experimental study;Fc Receptor;follow-up;Formulation;Generations;HGF gene;IgG1;imaging probe;immune checkpoint blockade;Immune checkpoint inhibitor;immune modulating agents;Immune system;Immunocompetent;Immunologics;Immunooncology;Immunotherapeutic agent;Incidence;Infiltration;inhibitor;Intervention;Joints;Laboratories;Lesion;Manuscripts;Measurable;Mediating;Melanoma;Melanoma patient;melanomagenesis;Metastatic Melanoma;Metastatic/Recurrent;Modality;Modeling;Molecular;Monitor;mouse model;multi-arm study;multidisciplinary;Mus;mutant;Mutation;Neoadjuvant Therapy;Neoplasm Metastasis;neoplastic cell;novel;Operative Surgical Procedures;Outcome;Pathway interactions;patient subsets;Pattern;PD-1 blockade;PD-L1 blockade;Pharmaceutical Preparations;Pharmacotherapy;pre-clinical;predictive signature;Primary Neoplasm;Privatization;Procedures;programs;Property;Recurrent tumor;repaired;Research Personnel;Resected;Resistance;response;Sampling;scaffold;Severities;Site;Surgical Models;targeted treatment;Testing;Therapeutic;Therapeutic Effect;Therapeutic Use Study;timeline;Tissues;tool;tumor;tumor growth;tumor microenvironment;Tumor-infiltrating immune cells;Vaccines;wound healing

PROJECT_TITLE: Preclinical GEM and GDA Models of Primary and Metastatic Melanoma


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Digestive Diseases;Gene Therapy;Genetics;Immunotherapy;Orphan Drug;Pancreatic Cancer;Rare Diseases

PROJECT_TERMS: Acinar Cell;Adult;Affinity;Alleles;Allografting;Animals;anti-cancer;Antibody-drug conjugates;Antigens;Automobile Driving;C57BL/6 Mouse;cancer cell;cancer imaging;Cancerous;CCR;Cell membrane;Cell Therapy;cell type;Cells;cellular transduction;chimeric antigen receptor T cells;Clinical;Clinical Trials;Collaborations;Collection;comparative;Cre driver;cytokine;cytotoxic;design;Desmoplastic;Development;Disease;Drug Kinetics;Duct (organ) structure;Ductal Epithelium;Engineering;Epitopes;Evaluation;experimental study;Extracellular Matrix;Fibroblasts;follow-up;Gene Modified;Genetic Engineering;Genetic Recombination;Genomic DNA;glycosylation;Goals;home test;Homing;Human;Hyaluronidase;Immune response;Immune system;immunogenic;Immunologics;improved;in silico;In Vitro;in vivo;Infiltration;Inflammatory;Influentials;Interleukin-12;Intraepithelial Neoplasia;Invaded;Joints;KPC model;KRAS oncogenesis;KRAS2 gene;KRASG12D;Laboratories;Legal patent;Lesion;Liver;Lung;Macrophage;Malignant - descriptor;Malignant neoplasm of pancreas;Malignant Neoplasms;Mediating;Membrane;Mesenchymal;mesothelin;Metaplasia;Modeling;Molecular Abnormality;Morphology;mouse model;Mus;mutant;Mutation;Myelogenous;Myeloid Cells;N-terminal;nanobodies;neoantigens;Neoplasm Metastasis;next generation;novel;Oncogenic;Pancreas;Pancreatic Adenocarcinoma;pancreatic cancer model;Pancreatic duct;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma model;pancreatic neoplasm;Pathway interactions;patient derived xenograft model;Patients;Pediatric Oncology;Pharmaceutical Preparations;Physiological;polypeptide;Population;pre-clinical;Pre-Clinical Model;pre-clinical research;Preclinical Drug Evaluation;precursor cell;premalignant;Primary Neoplasm;programs;Property;Protein Isoforms;Proteins;Publishing;Reagent;recombinant viral vector;Reporting;Research;Research Personnel;response;Single Nucleotide Polymorphism;Site;Therapeutic;Tissues;tool;TP53 gene;transcriptome sequencing;Transgenes;tumor;Tumor Antibodies;Tumor Antigens;Tumor Tissue;tumorigenic;Ultrasonography;Up-Regulation;uptake;Xenograft procedure

PROJECT_TITLE: Development and Preclinical Applications of Pancreatic Adenocarcinoma Models


NIH_SPENDING_CATS: Cancer;Clinical Research;Orphan Drug;Rare Diseases;Transplantation

PI_NAMEs: PAVLETIC, STEVEN  (contact)

PROJECT_TERMS: Address;Allogenic;Autoimmune Diseases;Biological Markers;Biology;Cancer Survivor;cancer therapy;Chronic;chronic graft versus host disease;Classification;Clinical;clinical phenotype;Clinical Research;Collaborations;Complication;Conduct Clinical Trials;disability;drug development;Evaluation;Extramural Activities;Hematopoietic Stem Cell Transplantation;Immune;Immunosuppression;International;Late Effects;multidisciplinary;Organ;Pathway interactions;Patient Care;Patients;prevent;programs;Research;Therapeutic Intervention;therapy development;tool;United States National Institutes of Health

PROJECT_TITLE: NIH Chronic GVHD Study Group


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Liver Cancer;Liver Disease;Pediatric;Pediatric Cancer;Rare Diseases

PI_NAMEs: ZHANG, PING  (contact)

PROJECT_TERMS: Adolescent and Young Adult;Affect;Ankyrins;Armadillo Repeat;Automobile Driving;Binding;Biochemical;Biological;Biological Models;Biological Process;Biology;Biophysics;bone;BRAF gene;Catalytic Domain;Cell Physiology;Cells;Chimera organism;Chimeric Proteins;Complex;Cryoelectron Microscopy;Cyclic AMP-Dependent Protein Kinases;Data;dimer;Disease;Family;Family Dasypodidae;Fibrolamellar Hepatocellular Carcinoma;Genetic;genetic regulatory protein;Goals;Guanosine Triphosphate Phosphohydrolases;Health;Heat-Shock Response;Holoenzymes;Human;human disease;Individual;Inherited;inhibitor;insight;Interdisciplinary Study;interest;Knowledge;Length;Leucine-Rich Repeat;Link;Liver diseases;LRRK2 gene;Malignant Childhood Neoplasm;Malignant neoplasm of liver;Malignant Neoplasms;Mammalian Cell;Medicine;MEKs;member;Modeling;Molecular;Molecular Chaperones;Molecular Conformation;monomer;Monomeric GTP-Binding Proteins;Mutation;N-terminal;novel therapeutic intervention;Oncogenic;Parkinson Disease;Pathologic;Pathway interactions;Patients;Phosphorylation;Phosphotransferases;Physiological;programs;protein function;Protein Kinase;Proteins;raf Kinases;Ras Signaling Pathway;Recording of previous events;Regulation;Research;Risk;Role;Signal Transduction;Structure;System;Tertiary Protein Structure;Therapeutic;transmission process;Vision;WD Repeat;Work;X-Ray Crystallography

PROJECT_TITLE: Mechanistic Analyses of kinase signaling complexes


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Human Genome;Immunotherapy;Lung;Lung Cancer;Orphan Drug;Patient Safety;Precision Medicine;Rare Diseases

PI_NAMEs: POMMIER, YVES  (contact)

PROJECT_TERMS: Adrenocortical Carcinoma;Biological Markers;Cancer Patient;Cell Cycle Checkpoint;Chromatin;Clinic;Clinical;clinical development;Clinical Trials;Combined Modality Therapy;Defect;DNA;DNA biosynthesis;DNA Damage;DNA Repair;DNA Sequence Alteration;Drug Targeting;Epigenetic Process;Gamma-H2AX;Genome;Genomic Instability;genomic signature;Genomics;H2AFX gene;Histones;immune checkpoint;inhibitor;insight;Malignant neoplasm of adrenal cortex;Malignant neoplasm of lung;Malignant Neoplasms;Metabolic;molecular marker;Molecular Target;neuroendocrine cancer;Neuroendocrine Tumors;novel therapeutic intervention;pharmacodynamic biomarker;Pharmacodynamics;Pharmacogenomics;pre-clinical;response;small cell lung carcinoma;targeted agent;targeted delivery;Testing;therapeutic development;TOP1 gene;Topoisomerase Inhibitors;tumor;Work

PROJECT_TITLE: Development Therapeutics Branch Clinical Trials


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Genetics;Immunotherapy;Neurofibromatosis;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases;Women's Health Research

PI_NAMEs: REILLY, KARLYNE M (contact)

PROJECT_TERMS: Acceleration;Affect;Anaplastic astrocytoma;Basic Science;Biological;Brain Neoplasms;cell growth;chemokine;Clinical Trials;cohort;Collaborations;Conduct Clinical Trials;cytokine;drug action;effective therapy;Excision;experimental study;Female;Genetic;genetic analysis;Genetic Diseases;Glioblastoma;Glioma;Gliomagenesis;Goals;Histone Deacetylase Inhibitor;Human;Immune system;Immunocompetent;Immunotherapy;Incidence;inhibitor;inhibitor therapy;interferon therapy;Interferons;Interleukins;kinase inhibitor;Knowledge;male;Malignant Glioma;Malignant Neoplasms;Modeling;Molecular;molecular targeted therapies;mouse model;Mus;Mutation;neoplastic cell;Nervous System;Neurofibromatosis 1;Neurofibrosarcoma;NF1 gene;Operative Surgical Procedures;Pathway interactions;Patients;peripheral blood;Peripheral Nerve Sheath Neoplasm;Pharmaceutical Preparations;Plexiform Neurofibroma;Protein Tyrosine Kinase;ras Oncogene;Research;Role;Sex Bias;Sex Differences;targeted treatment;Testing;Translational Research;tumor;Tumor Cell Line;tumor growth;tumorigenesis;Work

PROJECT_TITLE: Molecular, Cellular and Genetic Analyses of Malignancies Associated with NF1


PI_NAMEs: WU, CHUAN  (contact)

PROJECT_TERMS: Antigens;Autophagocytosis;Blood Circulation;Cell Line;Cell Physiology;cell type;Cells;commensal bacteria;Communication;Complex;Diet;Disease;Enterocytes;Epithelial Cells;Epithelium;Exposure to;Gastrointestinal Diseases;Goblet Cells;gut inflammation;gut microbiome;Homeostasis;host-microbe interactions;Immune;Immune system;Immunologics;Inflammation;Intervention;intestinal barrier;intestinal epithelium;Intestinal Mucosa;Intestinal permeability;Intestines;intraepithelial;Invaded;Mediating;Microbe;microbial;microbial homeostasis;microbial host;microorganism;Mucous body substance;Mucous Membrane;Nutrient;pathogen;Pathogenesis;Physiology;Play;prevent;Proteins;Regulation;Role;Structure;Symbiosis;Tissues;Toxin;uptake;Work

PROJECT_TITLE: Inter- and intra-epithelial regulation for intestinal barrier integrity


PI_NAMEs: COMPTON, ALEX  (contact)

PROJECT_TERMS: Address;antiviral immunity;Autophagocytosis;Basic Science;Benefits and Risks;Blood;CCI-779;cell growth;Cell Line;Cell Survival;Cells;Cellular Metabolic Process;cellular targeting;Clinical;clinical investigation;Clinical Research;Endocytosis;Endosomes;Epithelial Cells;FRAP1 gene;Gene Modified;gene therapy;Goals;Human;Immune response;Immunosuppressive Agents;improved;in vivo;Infection;Influenza A virus;inhibitor;Innate Immune Response;Interferons;Journals;knock-down;Knock-out;Lentivirus Vector;Link;Malignant Neoplasms;Mediating;Metabolic;Metabolic Pathway;mTOR inhibition;mutant;Oncogenic;Paper;Pathway interactions;Patients;permissiveness;Pharmaceutical Preparations;PIK3CG gene;Predisposition;Property;Regimen;scaffold;Signal Pathway;Signal Transduction;Sirolimus;therapeutic gene;Time;Tissues;tumorigenesis;Ubiquitination;vacuolar H+-ATPase;Viral;Virus;Work

PROJECT_TITLE: An Intrinsic Link between the Metabolic and Antiviral States of the Cell


NIH_SPENDING_CATS: Autoimmune Disease;Cancer;Genetics;Stem Cell Research;Stem Cell Research - Embryonic - Human

PI_NAMEs: WOLIN, SANDRA  (contact)

PROJECT_TERMS: Affect;Animals;Archaea;Autoantibodies;Autoantigens;Bacteria;Bacterial Genes;Bacterial RNA;Binding;Biogenesis;Cell Physiology;Cells;Clinical;Complex;Enzymes;Excision;Failure;Goals;Human;human disease;Individual;Introns;Laboratories;Ligation;Mammalian Cell;Metabolism;Mus;nuclease;Operon;Organism;Orthologous Gene;Pathway interactions;Patients;Play;Proteins;repaired;Rheumatism;Ribonucleases;Ribonucleoproteins;RNA;RNA Decay;RNA Degradation;RNA-Binding Proteins;Role;Shapes;Signal Pathway;Sjogren's Syndrome;Structure;Systemic Lupus Erythematosus;Transcription Coactivator;Transfer RNA;tRNA Precursor;Untranslated RNA;Work

PROJECT_TITLE: Biogenesis, Function and Turnover of Noncoding RNAs


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Digestive Diseases;Digestive Diseases - (Gallbladder);Genetics;Liver Cancer;Liver Disease;Ovarian Cancer;Rare Diseases;Women's Health Research

PI_NAMEs: HERNANDEZ, JONATHAN  (contact)

PROJECT_TERMS: 3-Dimensional;Biological Models;Biology;cancer care;CCR;Cells;Cholangiocarcinoma;clinical predictors;Clinical Trials;Couples;Cytoplasm;Development;Distant;Drug Evaluation;drug mechanism;epigenetic silencing;Excision;Exportins;Genes;Genetic;Goals;Human;imaging modality;Immune;Immune system;in vivo;inhibitor;Interruption;Kidney;Legal patent;Literature;Liver;Malignant neoplasm of ovary;Malignant Neoplasms;Mediating;Mediator;Metabolic;mimetics;Modeling;Molecular;mortality;Mutation;Neoplasm Metastasis;neoplastic cell;next generation sequencing;novel;Nuclear Export;Operative Surgical Procedures;Organ;Outcome;Pathway interactions;patient response;patient subsets;Patients;Perfusion;Peritoneal;Pharmaceutical Preparations;Phase;phase 2 study;Process;programs;Protein Export Pathway;Rare Diseases;Recurrence;response;Role;small molecule;Solid;Solid Neoplasm;stem;System;targeted agent;Therapeutic;tool;tumor;Tumor Biology;tumorigenesis;Up-Regulation

PROJECT_TITLE: Interrogating the molecular underpinnings of metastatic colonization


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Genetics;Neurosciences;Orphan Drug;Rare Diseases

PI_NAMEs: YANG, CHUN ZHANG  (contact)

PROJECT_TERMS: Anabolism;Animal Model;Antioxidants;beta-Transducin Repeat-Containing Proteins;Binding;Biochemical Pathway;Brain Neoplasms;brain pathway;cancer cell;Cell Death;Cell Line;Cell model;Cells;Cellular biology;cellular transduction;Consumption;coping;CRISPR screen;Cysteine;Data;Disease Outcome;Dissection;Drug Screening;Enzymes;Exhibits;experimental study;F Box Domain;Family;GCLC gene;GCLM gene;Genes;Genetic Transcription;Glioma;Glutamate-Cysteine Ligase;Glutamates;Glutathione;Glutathione Metabolism Pathway;Glycine;glycogen synthase kinase 3 beta;Goals;Guide RNA;Half-Life;Homeostasis;Impairment;improved;In Vitro;in vivo;inhibitor;interest;Investigation;Malignant Neoplasms;member;Metabolic;Metabolic Pathway;Metabolic stress;Mitochondria;Molecular;Molecular Biology;Molecular Target;mRNA sequencing;mutant;Mutate;Mutation;NADP;Natural Compound;neoplastic cell;novel;novel therapeutic intervention;nuclear factor-erythroid 2;Oxidation-Reduction;oxidative damage;Pathway interactions;Patients;Phosphorylation;PI3K/AKT;Play;pre-clinical;programs;Proliferating;Promoter Regions;protein degradation;Proteins;Reactive Oxygen Species;Reduced Glutathione;Respiration;RNA library;Role;solute;stem cells;Structure;synergism;Therapeutic;therapeutic target;transcription factor;Transcriptional Activation;transcriptome;Translations;triptolide;ubiquitin-protein ligase;Ubiquitination;WD Repeat;Xenograft procedure

PROJECT_TITLE: Nrf2-goverened metabolic reprogram in IDH1-mutated glioma


NIH_SPENDING_CATS: Cancer;Regenerative Medicine;Skin Cancer;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

PI_NAMEs: IGLESIAS-BARTOLOME, RAMIRO  (contact)

PROJECT_TERMS: Adult;adult stem cell;aging related;Alternative Therapies;Basal Cell;Basal cell carcinoma;Biological Models;cancer initiation;Cell Differentiation process;Cell Proliferation;cell regeneration;Cell Surface Receptors;Cells;Cyclic AMP-Dependent Protein Kinases;Dedications;Development;Diagnosis;Disease;Epithelial Cell Proliferation;Epithelial Cells;Epithelium;Equilibrium;Erinaceidae;Excision;Family;G-Protein-Coupled Receptors;G-substrate;Genetic Transcription;Goals;Growth;GTP-Binding Proteins;healthcare burden;Heterotrimeric G Protein Subunit;High Prevalence;Homeostasis;Human;Immunotherapy;Impairment;inhibitor;insight;interest;Intervention;keratinocyte;Laboratory Study;Location;Malignant Neoplasms;mouse model;Mus;Mutation;neoplastic cell;novel;novel therapeutic intervention;Oncogenic;Pathology;Pathway interactions;pharmacologic;programs;Proliferating;Proteins;Regulation;Research;Role;side effect;Signal Transduction;Skin;Skin Cancer;Skin Carcinoma;smoothened signaling pathway;stem cells;success;therapy resistant;tissue regeneration;Tissues;tumor;United States

PROJECT_TITLE: Regulation of epithelial cell fate decisions in tissue homeostasis and cancer


NIH_SPENDING_CATS: Autoimmune Disease;Cancer;Genetics

PI_NAMEs: LAZAREVIC, VANJA  (contact)

PROJECT_TERMS: Adaptive Immune System;Affinity;antimicrobial;Autoimmune Diseases;Autoimmune Responses;Autoimmunity;Automobile Driving;CD4 Positive T Lymphocytes;Cell Differentiation process;Cells;chronic inflammatory disease;Cues;Development;EGR2 gene;functional plasticity;gene regulatory network;Genetic Transcription;Helper-Inducer T-Lymphocyte;Homeostasis;Hypersensitivity;IL17 gene;immune function;Immune response;Immunity;immunopathology;Inflammatory Response;Maintenance;Nature;neuroinflammation;pathogen;Pathogenesis;Pathogenicity;Play;programs;repaired;Research;response;Role;Site;Tissue Preservation;Tissues;transcription factor;Transcriptional Regulation

PROJECT_TITLE: Transcriptional regulation of inflammatory and autoimmune responses


PI_NAMEs: DE OLIVEIRA RODRIGUES BATISTA, PEDRO  (contact)

PROJECT_TERMS: Acute;alpha ketoglutarate;Bacteria;Binding;Biogenesis;cancer cell;Cancer cell line;cancer type;Cell Fate Control;Cell Proliferation;Cells;cellular engineering;Chemistry;Chronic;Comparative Study;Development;Dioxygenases;Disease;Energy Metabolism;Environment;Enzymes;epigenome;experimental study;Family;Follow-Up Studies;Fumarates;Gene Expression;Genome;Goals;Growth;Health;Homeostasis;Human;improved;inducible gene expression;Isocitrate Dehydrogenase;Malignant Neoplasms;Maps;Measures;Metabolic;Metabolism;Methods;Modeling;Modification;Molecular;Mutate;Pathway interactions;Phenotype;Play;Positioning Attribute;Proliferating;Protocols documentation;Regulation;Regulator Genes;RNA;RNA methylation;Role;Succinate Dehydrogenase;Succinates;Surveys;Tissues;Transfer RNA;Translations

PROJECT_TITLE: Regulation of RNA biogenesis and function by RNA modifications


PI_NAMEs: DAI, CHENGKAI  (contact)

PROJECT_TERMS: Affect;Amyloid;amyloid formation;amyloidogenesis;analog;assault;Automobile Driving;c-myc Genes;cancer addiction;Cancer Biology;cancer cell;cancer therapy;Cell Death;Cell Survival;combat;Complex;Congo Red;DNA Binding;experimental study;Gene Expression;Genetic;Genetic Transcription;genome-wide;Genomic DNA;Goals;Heat-Shock Response;Histone Acetylation;histone acetyltransferase;HSF1;Human;Impairment;in vivo;Investigation;knock-down;Laboratories;Leucine;Malignant Neoplasms;MAPK8 gene;Mediating;Mitochondria;Molecular Chaperones;neoplastic cell;Neurofibrosarcoma;NF1 gene;novel;novel therapeutic intervention;novel therapeutics;Oncogenic;Outcome;pharmacologic;preservation;Proteins;Proteome;Proteomics;proteostasis;proteotoxicity;recruit;Repression;Research;Research Project Grants;Role;Schwann Cells;Stress;stressor;transcription factor;Translational Repression;Translations;TSC2 gene;tumor;tumor growth;Ubiquitination;Xenograft Model

PROJECT_TITLE: Preservation of Proteomic Stability and Promotion of Protein Lipidation by HSF1


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Clinical Research;Neurosciences;Rare Diseases

PI_NAMEs: ARMSTRONG, TERRI S. (contact)

PROJECT_TERMS: Biological Specimen Banks;Budgets;CCR;Central Nervous System Neoplasms;Clinical;Collection;design;Disease;Education;Future;Genetic;high risk;interest;Malignant neoplasm of central nervous system;Natural History;neuro-oncology;Paper;Patients;Phase;Probability;Protocols documentation;sociodemographics;Syndrome;tumor

PROJECT_TITLE: Natural History and Specimen Banking for Patients with CNS Tumors


PI_NAMEs: MUPPIDI, JAGAN  (contact)

PROJECT_TERMS: Accounting;activated B cell like;Address;Age;aged;Aging;Alleles;animal old age;Animals;Antibiotic Therapy;Antibodies;Antibody Affinity;Antigens;Area;ARHGEF1 gene;Autoimmunity;B-Lymphocytes;BCL2 gene;Biology;Cecum;cell behavior;Cell Cycle Inhibition;Cell Cycle Progression;Cell Death;Cell Death Induction;Cell Lineage;cell motility;Cell Survival;Cells;Chronic;Coupled;Cues;Data;Dependence;Development;Diet;Distal;Distant;draining lymph node;G Protein-Coupled Receptor Signaling;gain of function;gain of function mutation;Gene Expression;Generations;Genes;Genetic;Goals;GTP-Binding Proteins;Guanine Nucleotide Exchange Factors;Guanine Nucleotides;gut microbiota;Homeostasis;Host Defense;Human;Humoral Immunities;Immune response;Immunization;Immunoglobulin M;in vivo;Infection;insight;Knock-in;large cell Diffuse non-Hodgkin's lymphoma;Lobe;Lymph;lymph nodes;Lymphoid Tissue;Lymphoma;Lymphomagenesis;Malignant Neoplasms;Mediating;Memory;Memory B-Lymphocyte;mesenteric lymph node;microbial products;microbiota;Modeling;Molecular;molecular subtypes;Monomeric GTP-Binding Proteins;Mucous Membrane;Mus;Mutagenesis;Mutation;MYC Family Protein;novel;Nutrient;off-target mutation;overexpression;Pathway interactions;Peripheral;Peyer's Patches;Plasma Cells;PRDM1 gene;prevent;Process;programs;protein expression;Reaction;regional difference;Research;response;rho GTP-Binding Proteins;Role;Signal Transduction;Signaling Protein;Site;Small Intestines;Somatic Cell;Spleen;Stimulus;Structure of germinal center of lymph node;System;Testing;TLR7 gene;transcription factor;tumor;Virus Diseases;Work

PROJECT_TITLE: The role of Galpha13 signaling in suppression of lymphoma


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Congenital Structural Anomalies;Genetics;Neurosciences;Pediatric;Rare Diseases

PI_NAMEs: ZHUANG, ZHENGPING  (contact)

PROJECT_TERMS: Affect;Alleles;Applied Research;autosome;Basic Science;BHLH Protein;bHLH-PAS factor HLF;Binding;Bioenergetics;Body System;Cancer Biology;cancer genetics;Cardiovascular system;Carotid Body;Catecholamines;Cell model;cell type;Cells;Central Nervous System;Citric Acid Cycle;Clear Cell;Clinic;Clinical;clinical investigation;Clinical Research;Clinical Sciences;Collaborations;Congenital Abnormality;congenital anomaly;Cyst;Dedications;Development;Dimerization;Disease;disease-causing mutation;Embryo;Environment;Epigenetic Process;Equilibrium;Event;Extramural Activities;Family;Functional disorder;gain of function;Gene Mutation;Genes;Genetic;genetic variant;Germ Lines;Glioma;Goals;Human;Hydroxylation;Hyperplasia;Hypoxia;Hypoxia Inducible Factor;hypoxia inducible factor 1;Inherited;innovation;insight;interest;Intramural Research Program;Investigation;Knowledge;Laboratories;Laboratory Research;Lead;Link;loss of function;malformation;Malignant Neoplasms;Mediating;meningioma;Metabolic;Metabolism;migration;Modeling;Molecular;mosaic nature;Mosaicism;mouse model;multicatalytic endopeptidase complex;multidisciplinary;Mutation;Nature;NCI Center for Cancer Research;Neoplasm Metastasis;Neoplasms;Neoplasms in Vascular Tissue;neoplastic;neoplastic cell;nerve stem cell;Nervous System Neoplasms;Neural tube;neuro-oncology;Normal tissue morphology;normoxia;novel;Nuclear Translocation;Oncogenic;organ growth;Oxygen;Paraganglioma;Pathogenesis;Pathology;Pathway interactions;Patient Care;Patients;Phenotype;Physiological Processes;Play;Polycythemia;Predisposition;Procollagen-Proline Dioxygenase;Production;programs;Proline;Proteins;Regulation;Research;Research Personnel;Rhabdoid Cell;Role;Scientist;sexual dimorphism;Shunt Device;Signal Pathway;Signal Transduction;Somatic Mutation;Somatostatinoma;stem cell biology;Syndrome;System;targeted cancer therapy;Therapeutic;Therapeutic Studies;therapeutic target;Transgenic Mice;Transgenic Model;Translational Research;tumor;tumor progression;tumorigenesis;ubiquitin-protein ligase;Variant;Vascularization;vasculogenesis;VHL mutation;VHL protein;Von Hippel-Lindau Syndrome;Work

PROJECT_TITLE: Hypoxia signaling in cancer development


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Genetics;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

PI_NAMEs: HESKE, CHRISTINE  (contact)

PROJECT_TERMS: Adolescent and Young Adult;Area;cancer cell;Cancer Model;Cells;chemotherapy;Childhood;childhood sarcoma;Childhood Solid Neoplasm;Clinic;Clinical;clinical candidate;Clinical Research;Collaborations;combinatorial;Development;Developmental Therapeutics Program;DNA Damage;DNA Repair;DNA-dependent protein kinase;Doxorubicin;Drug Exposure;Enzymes;Etoposide;Ewings sarcoma;Genetic;Genetic Screening;Goals;Heat-Shock Proteins 90;Impairment;improved;inhibitor;inhibitor therapy;interest;irinotecan;lactate dehydrogenase A;Malignant Childhood Neoplasm;Malignant Neoplasms;Metabolic;Metabolism;Modeling;National Center for Advancing Translational Sciences;nicotinamide phosphoribosyltransferase;novel;novel therapeutics;Osteosarcoma;Pathway interactions;patient derived xenograft model;patient population;Patients;pharmacologic;phase 1 testing;Population;pre-clinical;Pre-Clinical Model;preclinical evaluation;preclinical study;Publishing;refractory cancer;replication stress;Research Personnel;Rhabdomyosarcoma;Role;Sarcoma;Screening procedure;standard of care;targeted agent;Testing;Topoisomerase;Translating;Translations;tumor;tumor DNA;tumor metabolism;Urologic Oncology;Work

PROJECT_TITLE: Development and translation of novel therapies for pediatric sarcoma


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Cancer;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases

PROJECT_TERMS: 2019-nCoV;Acute;Amphipathic Alpha Helix;Anti-viral Therapy;Binding;biophysical properties;Cell Physiology;Cells;Cellular Membrane;Cellular Structures;Cholesterol;Communication;Cryoelectron Microscopy;Development;Ensure;Event;Exhibits;Family member;gene therapy;Glean;Glucose;HIV-1;Human;human pathogen;IFITM1 gene;Immune response;Immunologic Factors;Immunology;in silico;Infection;Influenza A virus;insight;Integral Membrane Protein;interest;Interferons;Journals;Learning;Mediating;Membrane;Membrane Fluidity;Membrane Fusion;Molecular;Molecular Biology;molecular dynamics;Nature;neurotransmission;new therapeutic target;novel;pathogenic virus;Pathway interactions;Play;Population;prevent;Process;Property;Protein Family;Proteins;Publishing;response;restoration;Role;Signal Transduction;SNAP receptor;Structure;Therapeutic Intervention;trafficking;tumorigenesis;tumorigenic;Viral;Viral Physiology;viral transmission;Virion;Virus;Virus Diseases;Virus Replication;Work;Zika Virus

PROJECT_TITLE: Mechanisms of Virus Entry into Cells and Antiviral Barriers Limiting Entry


NIH_SPENDING_CATS: Cancer;Clinical Research;Hematology;Immunotherapy;Lymphatic Research;Lymphoma;Rare Diseases

PI_NAMEs: STAUDT, LOUIS  (contact)

PROJECT_TERMS: Accounting;anti-CD20;Apoptotic;BCL2 gene;Belief;Bypass;cell killing;Cell Line;Cell Survival;Cells;Chemicals;chemotherapy;chimeric antigen receptor T cells;Clinical;clinical development;clinical investigation;Combination Drug Therapy;Development;Drug Combinations;Drug Targeting;Family member;functional genomics;Genetic;Glucocorticoid Receptor;Immunotherapy;In complete remission;inhibitor;IRF4 gene;JAK1 gene;Journals;Laboratories;large cell Diffuse non-Hodgkin's lymphoma;lenalidomide;Lymphoma;Lymphoma cell;MCL1 gene;Medicine;Molecular;Molecular Profiling;molecular subtypes;Monitor;Monoclonal Antibody CD20;New England;NF-kappa B;Non-Hodgkin's Lymphoma;Oncogenic;Other Genetics;Outcome;overexpression;Pathway interactions;Patients;Pharmaceutical Preparations;PIK3CG gene;Pre-Clinical Model;Predisposition;Prednisone;Progression-Free Survivals;Recovery;Refractory;Regimen;Relapse;Reporting;Resistance;response;Revlimid;Safety;Signal Transduction;STAT3 gene;Survival Rate;targeted agent;Testing;Toxic effect;Translating;trial design;tumor;tumor DNA

PROJECT_TITLE: Clinical development of mechanism-based lymphoma therapies


PI_NAMEs: ALTAN-BONNET, GREGOIRE  (contact)

PROJECT_TERMS: anti-CD20;Autoimmune;Biological Phenomena;Blood;Bone Marrow;Cancer Burden;Candida;cell type;Cells;checkpoint inhibition;Choristoma;cytokine;Disease;Erythrocytes;Goals;Hematology;Hematopoiesis;Hematopoietic;hematopoietic differentiation;Hematopoietic System;Homeostasis;Immune system;Immunotherapy;Infection;Inflammatory;interest;Leukocytes;Lymphoid Cell;Manuscripts;Measurement;Modeling;Mus;Myeloid Cells;Organ;Organism;response;Rest;Signal Transduction;Spleen;stem;Testing;Tissues;tumor immunology;tumorigenesis;Vascular blood supply;White Blood Cell Count procedure;Work

PROJECT_TITLE: Dynamics of hematopoietic differentiation


NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics;Prostate Cancer;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Urologic Diseases

PI_NAMEs: KELLY, KATHLEEN  (contact)

PROJECT_TERMS: Address;Adenocarcinoma;Adenocarcinoma Cell;Adopted;androgen independent prostate cancer;Androgen Receptor;anti-cancer research;aurora kinase A;Automobile Driving;Biological;Biological Assay;Biological Markers;biomarker driven;Biopsy;Biopsy Specimen;bone;Cancer Biology;Cancer Patient;cancer therapy;Castration;CD276 gene;Cell Count;Cell Line;Cell Proliferation;Cells;Characteristics;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;Communities;Coupled;Data;disease heterogeneity;DNA Crosslinking Agent;DNA Repair;Dropout;efficacious treatment;enzalutamide;Epithelium;Evolution;Genetic Transcription;Genomics;Genotype;Goals;Heterogeneity;In Vitro;in vitro Model;in vivo;inhibitor;insight;Malignant neoplasm of prostate;Membrane Proteins;Mesenchymal;Metastatic Prostate Cancer;Methodology;Modeling;Molecular;Mutation;Neoplasm Metastasis;neoplastic cell;neuroendocrine phenotype;Neuroendocrine Prostate Cancer;Neurosecretory Systems;Organoids;Pathogenesis;patient derived xenograft model;patient population;Patients;Pharmaceutical Preparations;Phenotype;Population;Pre-Clinical Model;preservation;Procedures;progenitor;Prognosis;Prostate;Prostate Adenocarcinoma;prostate cancer model;pyrrolobenzodiazepine;RB1 gene;Receptor Inhibition;replication stress;Reporting;Research;Resistance;response;self-renewal;stem;stem cells;stemness;success;System;Therapeutic;Therapeutic antibodies;Tissues;TP53 gene;treatment response;trial design;tumor;tumor growth;Work

PROJECT_TITLE: Mechanisms of pathogenesis in patient derived organoid models of prostate cancer


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Clinical Research;Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Neurosciences;Orphan Drug;Precision Medicine;Rare Diseases

PI_NAMEs: GILBERT, MARK  (contact)

PROJECT_TERMS: Acceleration;analytical tool;Animals;Area;Belief;Big Data;Biochemical Pathway;Bioinformatics;bioinformatics tool;Biological;Biological Process;Biology;Biomedical Research;Blood specimen;Brain Neoplasms;Cancer Genome Anatomy Project;Cancer Research Project;cDNA Arrays;cell behavior;Cell Line;Cells;Central Nervous System Neoplasms;Chordoma;Classification;clinical care;Clinical Data;clinical practice;Clinical Trials;Collaborations;Collection;companion diagnostics;Complex;Computer Analysis;Data;data acquisition;Data Analyses;data platform;data streams;data warehouse;Databases;Decision Making;design;Development;differential expression;Disease;DNA;DNA biosynthesis;DNA Sequence;driving force;drug development;Enrollment;Evolution;Explosion;Formalin;Freezing;Functional disorder;Funding;Gene Expression Profile;Gene Expression Profiling;Generations;Genes;Genetic;Genetic Transcription;genome wide methylation;genome-wide;Genomic Data Commons;genomic profiling;Genomics;Germ Lines;Glioma;histone methylation;Human;Human Genome Project;Hybrids;Impact evaluation;improved;In Vitro;in vivo;Information Storage;Laboratories;laboratory experiment;Link;Mainstreaming;Malignant neoplasm of central nervous system;Malignant Neoplasms;Maps;metabolomics;methylation pattern;Microarray Analysis;MicroRNAs;Mining;Modality;Molecular;Molecular Analysis;molecular diagnostics;molecular targeted therapies;Monitor;Morphology;mRNA Translation;Natural History;Nature;neuro-oncology;novel;novel therapeutics;Nucleic Acids;older patient;Paraffin Embedding;participant enrollment;patient prognosis;patient stratification;Patients;Pattern;peripheral blood;Pharmacotherapy;Phenotype;precision medicine;Process;programs;prospective;protein aminoacid sequence;protein distribution;Proteins;Proteomics;Research;Research Personnel;Resolution;Resources;RNA chemical synthesis;sample collection;Sampling;Science;Signal Transduction Pathway;small molecule;Source;stem cells;System;Techniques;Technology;The Cancer Genome Atlas;Therapeutic;therapeutic biomarker;therapeutic target;three dimensional structure;Time;Tissue Sample;Tissues;transcriptomics;Translating;Treatment Efficacy;treatment response;treatment stratification;Tumor Biology;Tumor Tissue;user-friendly;Variant;whole genome;Work

PROJECT_TITLE: Bioinformatics: Characterizing Brain Tumor Data


NIH_SPENDING_CATS: Cancer

PI_NAMEs: NICKLAUS, MARC  (contact)

PROJECT_TITLE: Better Understanding and Handling of Tautomerism


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Rare Diseases

PI_NAMEs: LIN, FRANK  (contact)

PROJECT_TERMS: early phase clinical trial;Goals;improved;Literature;Metastatic Pheochromocytoma;National Institute of Child Health and Human Development;Paraganglioma;Patients;phase 2 study;Progression-Free Survivals;rare cancer;safety assessment

PROJECT_TITLE: Phase 2 study of Lu-177-DOTATATE in inoperable paraganglioma - pheochromocytoa


NIH_SPENDING_CATS: Biomedical Imaging;Brain Cancer;Brain Disorders;Cancer;Neurosciences;Radiation Oncology;Rare Diseases

PI_NAMEs: SMART, DEEDEE  (contact)

PROJECT_TERMS: Affect;Amines;Animal Model;Animals;Brain;Brain Neoplasms;Chemicals;Clinical;Contrast Media;Cranial Irradiation;Diagnostic;experience;Future;Glutamate Metabolism Pathway;Glutamates;Hippocampus;Human;human subject;human tissue;Image;imaging facilities;Imaging Techniques;in vivo;Location;magnetic field;Magnetic Resonance Imaging;Measurable;Measures;Memory impairment;Metabolic;metabolic imaging;Methodology;Modeling;Molecular;Mus;Nerve Degeneration;neurotoxicity;Neurotransmitters;Oncology;Outcome;Patients;pre-clinical;Protons;Radiation;Radiation induced damage;radiation mitigator;radiation response;Radiation therapy;Radiation Toxicity;Radiation-Protective Agents;Recovery;Reporting;Research;Signal Transduction;Stress;Techniques;Testing;Therapeutic;Time;Tissues;tool;tumor;United States National Institutes of Health;Water

PROJECT_TITLE: Metabolic imaging of the effects of brain radiotherapy


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Human Genome;Immunotherapy;Lung;Lung Cancer;Orphan Drug;Precision Medicine;Rare Diseases

PI_NAMEs: THOMAS, ANISH  (contact)

PROJECT_TERMS: Address;American Society of Clinical Oncology;anti-cancer research;anti-tumor immune response;Antibody-drug conjugates;ATR gene;Award;Benchmarking;Biology;Biopsy;cancer cell;Cancer cell line;cancer heterogeneity;Cancer Science;cancer subtypes;cancer therapy;Cancer-Predisposing Gene;CAR T cell therapy;career;cell type;Cells;cellular targeting;Cessation of life;Characteristics;CHEK1 gene;Chemoresistance;chemotherapy;Chromosome abnormality;Chromosome Segregation;Clinical;Clinical Data;Clinical Trials;clinically relevant;clinically significant;Complex;Diagnosis;Disease;Disease remission;Disease Resistance;DNA;DNA amplification;DNA Damage;DNA Double Strand Break;DNA replication fork;Effectiveness;Epigenetic Process;epithelial to mesenchymal transition;Exclusion;Exhibits;extrachromosomal DNA;EZH2 gene;Faculty;Foundations;Future;gemcitabine;Gene Expression Profile;Gene Expression Profiling;Genes;Genetic;Genetic Transcription;Genetic Variation;Genomic Instability;Genomics;Goals;Heterogeneity;histone modification;Human;Immune;immune activation;immune checkpoint blockade;immune resistance;Immuno-Chemotherapy;Immunotherapy;improved;Inherited;inhibitor;insight;Intrinsic factor;JAK1 gene;K-Series Research Career Programs;Knowledge;Laboratories;Learning;life span;Malignant neoplasm of lung;Malignant Neoplasms;Maps;meetings;Mentors;Mismatch Repair Deficiency;Mission;Molecular;Molecular Profiling;Mutation;Neoplasm Metastasis;neoplastic cell;Neuroendocrine Cell;Neurosecretory Systems;next generation;non-genetic;Normal tissue morphology;notch protein;novel;novel therapeutic intervention;Nucleosomes;Outcome;paralogous gene;PARP inhibition;partial response;Patient Selection;Patients;Pattern;PDL1 inhibitors;personalized care;personalized medicine;Pharmacodynamics;phase I trial;phase II trial;Phenotype;Phosphorylation;Phosphotransferases;Physicians;Plasma;Play;Poly(ADP-ribose) Polymerase Inhibitor;Population;predicting response;Prediction of Response to Therapy;programs;Progression-Free Survivals;Quality of life;Randomized;Recurrence;Relapse;replication stress;Research;Research Personnel;Resistance;response;Risk Factors;Role;Scientific Advances and Accomplishments;Scientist;Shapes;Signal Transduction;Small Cell Carcinoma;small cell lung carcinoma;Smoking;Stress;stress management;targeted treatment;Techniques;The Cancer Genome Atlas;Therapeutic;therapy resistant;Time;Tissues;TOP1 gene;Topotecan;Toxic effect;transcriptomics;translational approach;Treatment outcome;tumor;Tumor Antigens;tumor DNA;tumor heterogeneity;Tumor Immunity;Tumor Markers;tumor microenvironment;tumor progression;Tumor Subtype;Tumor Suppressor Proteins;Work

PROJECT_TITLE: Exploiting DNA Replicative Stress for Novel Small Cell Lung Cancer Therapies


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Diabetes;Digestive Diseases;Genetics;Human Genome;Pancreatic Cancer;Rare Diseases

PI_NAMEs: ARDA, HATICE  (contact)

PROJECT_TERMS: Body System;Categories;Cell Lineage;cell type;Cells;Chromatin;Development;Diabetes Mellitus;diabetes risk;DNA;DNA Sequence;Elements;Enhancers;Exocrine pancreas;Gene Expression;Genome Mappings;Genomics;Goals;interest;Islets of Langerhans;Link;Logic;Malignant neoplasm of pancreas;Maps;Pancreas;Pancreatic Diseases;programs;reference genome;Regenerative Medicine;Regulatory Element;Research;risk variant;Technology;Work

PROJECT_TITLE: Identification of genomic regulatory elements in pancreas cells


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Digestive Diseases;Immunotherapy;Liver Cancer;Liver Disease;Orphan Drug;Radiation Oncology;Rare Diseases

PI_NAMEs: ESCORCIA, FREDDY  (contact)

PROJECT_TERMS: Ablation;Antibodies;Biological;cancer type;Cessation of life;Death Rate;Detection;Development;Diagnosis;Disease;Engineering;Excision;falls;first-in-human;Goals;high risk;Image;imaging agent;Immunotherapy;improved;Incidence;intrahepatic;Intravenous;Legal patent;Length;liver cancer model;Magnetic Resonance Imaging;Malignant neoplasm of liver;Malignant Neoplasms;Modality;Molecular;mouse model;nanobodies;novel;palliative;Patient Selection;Patients;Phase;Positron-Emission Tomography;Primary carcinoma of the liver cells;Radiation therapy;Radioembolization;Radiopharmaceuticals;screening;Survival Rate;Translating;Transplantation;treatment planning;tumor;United States;X-Ray Computed Tomography

PROJECT_TITLE: Engineering HCC-selective PET agent


NIH_SPENDING_CATS: Cancer;Digestive Diseases

PI_NAMEs: WU, CHUAN  (contact)

PROJECT_TERMS: Antigens;CD4 Positive T Lymphocytes;Cell Communication;Cell Physiology;Cells;dietary;Enterocytes;Epithelial Cells;Epithelium;gut inflammation;Homeostasis;Immune;Immune Tolerance;interest;intestinal barrier;intestinal epithelium;intestinal homeostasis;Intestines;intraepithelial;Invaded;Microbe;Molecular;Mus;Play;response;Risk;Role;Signal Transduction;Symbiosis;T cell regulation;T-Lymphocyte

PROJECT_TITLE: T cell regulation for intestinal barrier function


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Precision Medicine

PI_NAMEs: RUPPIN, EYTAN  (contact)

PROJECT_TERMS: actionable mutation;Advanced Malignant Neoplasm;anti-cancer research;Antineoplastic Agents;cancer genetics;Cancer Patient;cancer therapy;Clinical;cohort;Data;Development;dosage;drug development;Drug resistance pathway;Drug Targeting;Drug usage;Effectiveness;fighting;Genes;Genetic;Genetic Complementation Test;genome-wide analysis;Genomics;improved;Laboratories;Malignant Neoplasms;Mediating;Methods;Mutation;patient stratification;Patients;Pharmaceutical Preparations;Pharmacotherapy;precision medicine;predicting response;Research;Resistance;response;Sampling;synthetic lethal interaction;targeted treatment;Therapeutic;tool;transcriptomics;tumor;whole genome;Work

PROJECT_TITLE: Discovery of genetic interactions in cancer


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Immunotherapy;Machine Learning and Artificial Intelligence;Neuroblastoma;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Precision Medicine;Rare Diseases;Skin Cancer

PROJECT_TERMS: anti-cancer;Binding;Biological Markers;cancer immunotherapy;cancer type;CAR T cell therapy;checkpoint therapy;computer studies;Data;Effectiveness;Gene Expression Profiling;Genes;genome-wide analysis;immune checkpoint blockade;Immune checkpoint inhibitor;Immune response;Immune system;Immunotherapy;Machine Learning;Malignant Neoplasms;Melanoma;Metastatic Melanoma;Neuroblastoma;new therapeutic target;NF1 gene;novel;Outcome;patient response;Patients;Pharmaceutical Preparations;predicting response;predictive tools;Reporting;response;Role;Shapes;targeted treatment;Testing;Translations;tumor heterogeneity;Tumor Suppressor Proteins;urea cycle

PROJECT_TITLE: Computational studies of cancer immunotherapy


NIH_SPENDING_CATS: Biotechnology;Cancer;Neuroblastoma;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

PI_NAMEs: YOHE, MARIELLE  (contact)

PROJECT_TERMS: Animals;Cell Culture Techniques;Cell Proliferation;Cells;Cessation of life;Childhood Solid Neoplasm;clinical development;clinical translation;Clinical Trials;FRAP1 gene;Goals;Growth;IGF1R gene;Induction of Apoptosis;inhibitor;Malignant Childhood Neoplasm;MAP Kinase Gene;MEK inhibition;MEKs;Mitogen-Activated Protein Kinase Inhibitor;Monoclonal Antibodies;Mutate;Mutation;Neoplasm Metastasis;Neuroblastoma;neuroblastoma cell;Pathway interactions;Patients;Pharmaceutical Preparations;pre-clinical;preclinical study;Primary Neoplasm;Proto-Oncogene Proteins c-akt;RAS inhibition;Ras Inhibitor;Refractory;Relapse;Resistance development;response;Rhabdomyosarcoma;small molecule;synergism;targeted agent;Testing;Therapeutic;tumor;tumor initiation;Work;Xenograft Model

PROJECT_TITLE: Dual Blockade of IGF1R and MEK synergistically inhibits pediatric cancers


PI_NAMEs: TAKAHAMA, YOUSUKE  (contact)

PROJECT_TERMS: Antigen Receptors;Antigens;Autoantigens;Biology;CCL21 gene;Cell Fate Control;Characteristics;Development;Embryo;Epithelial Cells;Epithelium;experimental study;Goals;Immune system;interest;Japan;Laboratories;Laboratory Research;Lymphocyte;Mature T-Lymphocyte;Molecular;pathogen;Play;Positioning Attribute;Process;Production;programs;Receptor Signaling;Research;Role;Self Tolerance;Specificity;Structure of thymic medulla;T-Lymphocyte;thymocyte;Thymus Gland

PROJECT_TITLE: Thymus biology


NIH_SPENDING_CATS: Cancer;Machine Learning and Artificial Intelligence

PROJECT_TERMS: Antibodies;Antigens;bioinformatics pipeline;Biological;Blood;Bone Marrow;Cell Differentiation process;Cell Proliferation;Cells;Coin;Collaborations;Communication;cytokine;Cytokine Signaling;Cytometry;Equilibrium;Goals;Grant;Hematology;Hematopoietic;high dimensionality;Homeostasis;Immune;Immunophenotyping;immunoregulation;Inflammation;Leukocytes;Lymphoid Tissue;Machine Learning;Manuscripts;Measurement;Measures;Methodology;Methods;Modeling;monocyte;Mus;Pharmaceutical Preparations;Phenotype;Physiologic pulse;Population;Preparation;Regulation;Research;Research Project Grants;Resolution;response;Running;Signal Pathway;Site;Spleen;Stains;T-Lymphocyte;Testing;tissue preparation;tumor;United States National Institutes of Health;White Blood Cell Count procedure;Work

PROJECT_TITLE: Immunophenotyping by high-dimensional cytometry  and machine learning


NIH_SPENDING_CATS: Cancer;Genetics;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

PI_NAMEs: RUIZ, SERGIO  (contact)

PROJECT_TERMS: Binding;Cell Nucleus;Cell Proliferation;Cells;Communication;Data;Defect;Development;Embryonic Development;Enhancers;Ensure;Extinction;Family;Gene Expression;Gene Expression Profile;Genes;Genetic Transcription;Goals;Growth;Malignant Neoplasms;MAP Kinase Gene;Membrane;Methyltransferase;Mouse Embryonic Stem Cells;Mus;NRAS gene;Nuclear;pluripotency;programs;Proteins;Publications;RAS genes;ras Proteins;Receptor Signaling;Role;Science;transcription factor;Transcription Repressor;transcriptome sequencing;Work

PROJECT_TITLE: Role of ETS-Transcription Factors in Regulating Cell Fate


NIH_SPENDING_CATS: Cancer;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

PROJECT_TERMS: Amino Acids;Biological Assay;cancer stem cell;CDK2 gene;Cell Cycle;Cell Cycle Regulation;Cell Line;Cell Nucleus;Cells;Chimeric Proteins;Consensus;Cytoplasm;Development;Diapause;Embryo;ES Cell Line;Food;gastrulation;Gene Expression Profile;Goals;HELB gene;human DNA;human embryonic stem cell line;In Vitro;interest;Label;live cell imaging;Maintenance;Mammals;Maps;Measures;Molecular;mouse model;Mus;mutant;Nuclear Export;Nuclear Localization Signal;Pathway interactions;Phosphorylation Site;Physiological;Process;Proliferating;Proteins;Reporter;sensor;Signal Transduction;single-cell RNA sequencing;small molecule libraries;spatiotemporal;Specific qualifier value;System;tumor;Validation;Visualization

PROJECT_TITLE: Identification of molecular pathways regulating quiescence in pluripotent cells


NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics

PI_NAMEs: VIDIGAL, JOANA  (contact)

PROJECT_TERMS: Binding;Biological Models;Catalytic Domain;Cell Culture Techniques;Cell Nucleus;Cell Proliferation;Cells;Cytoplasm;Data;Development;Disease;Elements;FRAP1 gene;Gene Expression;Genetic;Genetic Transcription;Genome;Goals;Homeostasis;in vivo;interest;Mammals;MicroRNAs;Mus;neuronal cell body;Nuclear;Pathway interactions;PIK3CG gene;posttranscriptional;Proteins;Proto-Oncogene Proteins c-akt;Regulation;Repression;RNA;RNA Interference;Role;Signal Transduction;Small RNA;Splenocyte;System;Testing;Tissues;tool;Whole Organism

PROJECT_TITLE: Canonical and non-canonical roles of Argonaute proteins in mammals


PROJECT_TERMS: Basic Science;Biomedical Research;Cells;Clinical Research;Code;Communication;Computer software;CRISPR screen;CRISPR/Cas technology;Data;design;Exons;fitness;Genome;genome-wide;genomic locus;Goals;Guide RNA;human disease;Libraries;Mammals;Manuscripts;Mediating;Molecular;Nature;Performance;Physiological;Proteins;Publications;RNA Sequences;RNA-Binding Proteins;Role;tool;Untranslated RNA

PROJECT_TITLE: CRISPR tools to dissect the coding and non-coding genome


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

PROJECT_TERMS: Binding Sites;Cell Death;Cells;ChIP-seq;Cleavage Under Targets and Release Using Nuclease;Communication;Complementary DNA;Data;Defect;Development;developmental plasticity;DNA Damage;Dose;Doxycycline;Embryo;embryo cell;Embryonic Development;Enhancers;Gene Cluster;Gene Expression Profile;Genes;Genome;Goals;Growth;Heterochromatin;Homeodomain Proteins;interest;knock-down;Maintenance;Malignant Neoplasms;Microinjections;Molecular;Nature;promoter;Protein Family;Proteins;Publications;Publishing;RNA Splicing;Rodent;Role;Totipotency;Totipotent;transcriptome sequencing;Whole Organism;Work;zygote

PROJECT_TITLE: Molecular Determinants of Totipotency


NIH_SPENDING_CATS: Cancer;Genetics

PI_NAMEs: LAZZERINI DENCHI, EROS  (contact)

PROJECT_TITLE: Identify modulators of telomerase activity


PROJECT_TERMS: Automobile Driving;cancer cell;cancer type;Canis familiaris;Cell Line;comparative genomics;Ensure;Genes;Genetic Recombination;Genomics;Human;inhibitor;Length;Malignant Neoplasms;Mediating;Molecular;novel;Osteosarcoma;Pathway interactions;pharmacologic;Process;Proliferating;telomere;Telomere Maintenance;therapeutic target

PROJECT_TITLE: Determine the mechanism of ALT-mediated telomere elongation


NIH_SPENDING_CATS: Cancer;Cystic Fibrosis;Infectious Diseases;Lung;Rare Diseases

PI_NAMEs: KHARE, ANUPAMA  (contact)

PROJECT_TITLE: Mechanisms of multi-species bacterial interactions


NIH_SPENDING_CATS: Antimicrobial Resistance;Cancer;Genetics;Infectious Diseases;Patient Safety

PROJECT_TERMS: Address;Antibiotic Resistance;Antibiotics;antimicrobial;Cessation of life;Evolution;Frequencies;Genes;Genetic Determinism;genomic locus;Genomics;Goals;Health;healthcare-associated infections;interest;Multi-Drug Resistance;mutant;novel;novel therapeutics;Pathway interactions;Play;Process;Role;Staphylococcus aureus;Testing;United States

PROJECT_TITLE: Evolution of antibiotic resistance


NIH_SPENDING_CATS: Biotechnology;Cancer;Childhood Leukemia;Clinical Research;Clinical Trials and Supportive Activities;Gene Therapy;Gene Therapy Clinical Trials;Genetics;Hematology;Immunotherapy;Lymphatic Research;Lymphoma;Orphan Drug;Pediatric;Pediatric Cancer;Prevention;Rare Diseases

PI_NAMEs: SHAH, NIRALI  (contact)

PROJECT_TERMS: Acute leukemia;Address;Adult;Age;Age Years;aged;Amendment;Antigen Targeting;Antigens;B lymphoid malignancy;B-Cell Acute Lymphoblastic Leukemia;B-Cell Leukemia;Back;bench to bedside;Biological;Biological Markers;Bispecific Antibodies;Blood;burden of illness;CAR antigen;CAR T cell therapy;Caring;CD19 gene;CD22 gene;Cell surface;Cell Therapy;cellular engineering;Chemoresistance;chemotherapy;Child;Childhood;chimeric antigen receptor T cells;Clinic;Clinical;clinical center;Clinical Trials;clinically relevant;Collaborations;combinatorial;Cytokine Receptors;Data;Data Set;design;Development;Disease;Disease remission;Dose;early phase clinical trial;eligible participant;Enrollment;Event;experience;experimental study;FDA approved;first-in-human;Flow Cytometry;Foundations;Frequencies;Future;Goals;Hematologic Neoplasms;Hemophagocytic Lymphohistiocytoses;Heterodimerization;high risk;Immune;immune effector cell-associated neurotoxicity syndrome;Immunotherapeutic agent;Immunotherapy;improved;improved outcome;Inflammatory;Infrastructure;Infusion procedures;insight;Investigation;Laboratories;leukemia/lymphoma;Mediating;Mission;Monitor;multidisciplinary;Myeloid Leukemia;Myeloproliferative disease;novel;novel strategies;novel therapeutics;Outcome;overexpression;Participant;patient stratification;Patient-Focused Outcomes;Patients;Phase;Phenotype;Philadelphia;pre-clinical;prevent;Process;programs;promoter;prospective;Prospective Studies;Publishing;receptor;Refractory;Relapse;Remission Induction;Research;Resistance;response;Risk Factors;risk mitigation;risk stratification;Safety;Salvage Therapy;Scientific Advances and Accomplishments;Series;Step Tests;Subgroup;T-Lymphocyte;targeted agent;Testing;Therapeutic;Therapeutic Index;Time;timeline;Toxic effect;Translating;translational approach;trial design;TSLP gene;United States National Institutes of Health;vector;Vision;Work;young adult

PROJECT_TITLE: Development of Novel Approaches to Optimize CAR T-cell Therapies for B-cell Malignancies


NIH_SPENDING_CATS: Cancer;Clinical Research;Dental, Oral, and Craniofacial Disease

PROJECT_TITLE: Protection of Salivary Gland in PSMA-targeted radioligand therapy


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Neurosciences;Pancreatic Cancer;Rare Diseases

PROJECT_TERMS: Combined Modality Therapy;DNA Damage;DNA Single Strand Break;gastroenteropancreatic neuroendocrine tumor;Lutetium;Malignant Neoplasms;Names;Neuroendocrine Tumors;Phase;Phase I/II Clinical Trial;Poly(ADP-ribose) Polymerase Inhibitor;Radioisotopes;repaired;stem

PROJECT_TITLE: Phase 1-2 study of Lu177-DOTATATE and olaparib in neuroendocrine tumors


NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Digestive Diseases;Liver Cancer;Liver Disease;Nutrition;Orphan Drug;Rare Diseases

PI_NAMEs: PORAT SHLIOM, NATALIE  (contact)

PROJECT_TERMS: Biopsy;cancer prevention;Cell Separation;chemotherapy;Classification;Death Rate;Diagnostic;Diet;Drug resistance;Electron Microscopy;Exhibits;Fasting;Genetic Variation;Hepatic;Hepatocyte;Heterogeneity;Human;Image Analysis;image guided;Incidence;insight;intravital microscopy;Knowledge;Liver;liver cancer model;Liver diseases;Liver parenchyma;Malignant neoplasm of liver;Malignant Neoplasms;Metabolic dysfunction;Metabolic stress;Modeling;Molecular;mortality;Mus;novel therapeutic intervention;Patients;Physiological;Physiology;Primary Malignant Neoplasm of Liver;Process;Technology;Therapeutic;Tissues;tumor;tumor heterogeneity;tumorigenesis;United States;western diet

PROJECT_TITLE: Hepatic organization and functions


NIH_SPENDING_CATS: Cancer

PI_NAMEs: CAPPELL, STEVEN  (contact)

PROJECT_TERMS: Cell Cycle;Cell Cycle Regulation;Cells;Defect;DNA Damage;DNA Replication Damage;Exhibits;Future;G1 Phase;G1/S Transition;Goals;Individual;inhibitor;live cell imaging;Mammalian Cell;Measurement;Modeling;Molecular;Morphologic artifacts;prevent;response;S phase;Signal Pathway;Source;Stress;Work

PROJECT_TITLE: Control of cell cycle commitment by APC-C-Cdh1


NIH_SPENDING_CATS: Biotechnology;Cancer;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Genetics;Immunotherapy;Orphan Drug;Rare Diseases

PI_NAMEs: SALOURA, VASSILIKI  (contact)

PROJECT_TERMS: Affect;Annual Reports;anti-PD1 therapy;Antibodies;Antisense Oligonucleotides;Binding;Biological Assay;cancer cell;cancer type;candidate identification;Categories;CD8-Positive T-Lymphocytes;Cell Cycle;Cell Line;Cell Nucleus;cell type;Cells;Cessation of life;chemokine;Chemotherapy and/or radiation;Chromatin;Chromatin Remodeling Factor;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;Co-Immunoprecipitations;Colon;Combined Modality Therapy;Complex;Cytoplasm;Deposition;design;Disease;Distant Metastasis;Drug Kinetics;efficacy study;Epigenetic Process;Epithelium;ERBB2 gene;exhaust;experimental study;Family;gain of function;Genes;Genetic;Genetic Transcription;genome-wide;Goals;head and neck cancer patient;Head and Neck Neoplasms;Head and Neck Squamous Cell Carcinoma;histone methylation;Histone-Lysine N-Methyltransferase;Histones;HPV negative;HPV positive;Human;Immune;Immunocompromised Host;Immunoprecipitation;Immunotherapy;In Vitro;in vivo;inhibitor;Interferon-beta;Interferons;knock-down;Knock-in;Label;Lead;loss of function;Malignant neoplasm of lung;Malignant neoplasm of pancreas;Malignant Neoplasms;Mass Spectrum Analysis;Mediating;Mesenchymal;Messenger RNA;Metastatic/Recurrent;Methods;Methylation;Methyltransferase;mouse model;multimodality;Mus;mutant;Neoadjuvant Therapy;new therapeutic target;novel therapeutic intervention;Nuclear Extract;Oncogenic;Operative Surgical Procedures;overexpression;Pathway interactions;Patients;Pattern;pembrolizumab;Peptides;Phenotype;Platinum;Primary carcinoma of the liver cells;Prognosis;programmed cell death protein 1;programs;promoter;Protac;Protein Methylation;Protein Methyltransferases;Proteins;Radiation therapy;Reader;Recombinant Proteins;recruit;Recurrence;Regulation;Reporting;Repression;Research;response;Role;SCID Mice;Set protein;Site;Small Interfering RNA;Sorting;T cell infiltration;Tobacco use;Toxic effect;Translating;Tritium;tumor;tumor growth;tumor xenograft;Up-Regulation;Vascular Endothelial Growth Factor Receptor-1

PROJECT_TITLE: The Role of Protein Methylation in Squamous Cell Carcinoma of the Head and Neck


NIH_SPENDING_CATS: Breast Cancer;Cancer;Women's Health Research

PROJECT_TERMS: CDK4 gene;Cell Cycle;Cell Cycle Regulation;Cells;Cellular Stress;Clinical;Data;Decision Making;Goals;hormone receptor-positive;Image;improved;inhibitor;innovation;Malignant Breast Neoplasm;Molecular;neoplastic cell;senescence

PROJECT_TITLE: Study cell cycle regulation in dormant tumor cells


NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics;Hematology;Human Genome;Lymphatic Research;Lymphoma;Rare Diseases

PI_NAMEs: MACKEM, SUSAN  (contact)

PROJECT_TERMS: Acute;Age;Alleles;Allografting;Amplifiers;c-myc Genes;cancer cell;cell type;Cells;Compensation;conditional knockout;Dependence;design;Development;DNA Sequence Alteration;dosage;effective therapy;Endothelial Cells;Endothelium;Excision;Future;Gene Dosage;Genetic Models;Genetic Predisposition to Disease;Genetic Recombination;genetic testing;Genetic Transcription;Genome;Genomics;Genotype;Germ-Line Mutation;Growth;Hemangiosarcoma;Immunohistochemistry;Induction of Apoptosis;Knockout Mice;Li-Fraumeni Syndrome;LoxP-flanked allele;Malignant Neoplasms;Modeling;Monitor;mouse genetics;Mus;mutant;MYC Family Protein;MYC gene;Neoplasms;Oncogenic;Outcome;Pathologic;Pathway interactions;Patients;Pharmaceutical Preparations;Physiological;programs;Recovery;Reporter;RNA;Role;Siblings;Spectral Karyotyping;Tamoxifen;Testing;Therapeutic;therapeutic target;Thymic Lymphoma;Tissues;TP53 gene;tumor;tumor growth;tumor progression;Tumor Promoters;tumorigenesis;tumorigenic

PROJECT_TITLE: Minimal Myc functional threshold for tumorigenesis


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Clinical Research;Neurosciences;Prevention;Rare Diseases

PI_NAMEs: ARMSTRONG, TERRI S. (contact)

PROJECT_TERMS: Adult;Brain Neoplasms;Cells;Central Nervous System Neoplasms;Characteristics;Clinical;clinical predictors;cohort;Data Reporting;Disease;Early Diagnosis;Environmental Risk Factor;Exposure to;functional status;Genes;Genomics;Glioma;Health Status;Incidence;Knowledge;Malignant neoplasm of central nervous system;Malignant Neoplasms;Mutation;Outcome;Paper;Participant;Patient Self-Report;Persons;Physicians;Population;Predisposition;Primary Prevention;Process;Publications;Quality of life;rare cancer;Reporting;Risk;Risk Factors;Scientist;Self Efficacy;Symptoms;tumor

PROJECT_TITLE: Outcomes and Risk of Rare Tumors


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Prostate Cancer;Urologic Diseases

PI_NAMEs: SOWALSKY, ADAM  (contact)

PROJECT_TERMS: advanced disease;Castration;Cessation of life;Clinical;Genomics;Immunocompromised Host;In Vitro;Intervention;Malignant neoplasm of prostate;Malignant Neoplasms;Metastatic Prostate Cancer;Molecular;Neoplasm Metastasis;novel therapeutics;Patients;Phenotype;prostate cancer metastasis;prostate cancer model;Proteomics;Recurrence;Resistance;resistance mechanism;Sampling;therapy resistant;transcriptomics;Treatment outcome

PROJECT_TITLE: Mechanisms of resistance to treatment in aggressive prostate cancers


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Orphan Drug;Precision Medicine;Rare Diseases

PI_NAMEs: WU, JING  (contact)

PROJECT_TERMS: antitumor effect;Apoptosis;Apoptotic;bench-to-bedside translation;Biochemical;Bioenergetics;biological adaptation to stress;Blood specimen;blood-brain barrier penetration;Brain Neoplasms;Cell Death Induction;cell killing;Cell model;Cells;Clinical;clinical investigation;Clinical Research;clinical trial analysis;Clinical Trials;cohort;Cohort Studies;Collaborations;Combined Modality Therapy;Contracts;CYP3A4 gene;Data;design;disease heterogeneity;Disease Resistance;disorder control;DNA Polymerase II;Dose;Drug usage;efficacy evaluation;Enrollment;Excision;Exhibits;Failure;FDA approved;Genetic Polymorphism;Glioblastoma;Glioma;glioma cell line;Growth;high-throughput drug screening;Hour;In Vitro;in vivo;in vivo Model;inhibitor;integration site;Investigational Drugs;Laboratories;Laboratory Finding;Laboratory Research;Link;Malignant Glioma;Malignant neoplasm of brain;Measures;Mitochondria;mitochondrial dysfunction;Modeling;Molecular;Moloney Leukemia Virus;mutant;Mutation;National Center for Advancing Translational Sciences;novel therapeutics;objective response rate;open label;Operative Surgical Procedures;Orphan Drugs;Oxidative Stress;Participant;Pathway interactions;Patient Outcomes Assessments;Patient Self-Report;Patients;Pharmaceutical Preparations;pharmacodynamic biomarker;Phase;phase I trial;Phase I/II Clinical Trial;phase II trial;Phosphorylation;Phosphotransferases;Plasma;pre-clinical;precision medicine;preclinical study;preservation;primary endpoint;Procedures;Process;Production;Progression-Free Survivals;Proteins;Provirus Integration;PTEN gene;Quality of life;Recommendation;Recurrence;resistance mechanism;response;RNA;Safety;screening;Severities;Survival Rate;Symptom Burden;Symptoms;systemic toxicity;targeted treatment;Testing;Therapeutic;Therapeutic Effect;therapy development;therapy resistant;Time;Tissue Sample;TOP1 gene;Transcription Process;transcriptomics;Translational Research;tumor;Tumor Biology;Tumor Tissue

PROJECT_TITLE: Discovering novel therapies for glioma patients


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Immunotherapy;Neurosciences;Orphan Drug;Rare Diseases

PROJECT_TERMS: aerobic glycolysis;Amendment;Biology;checkpoint therapy;Clinical;Clinical Management;clinical trial protocol;Clinical Trials;cohort;Collaborations;Compensation;Correlative Study;design;Detection;Development;Diffuse;Disease;Disease Progression;Enrollment;Excision;Extramural Activities;first-in-human;Funding;Glioblastoma;Glioma;Goals;Image;Imaging Device;imaging modality;imaging probe;imaging program;Immune checkpoint inhibitor;Investigational Therapies;Isocitrate Dehydrogenase;magnetic resonance spectroscopic imaging;Malignant Neoplasms;Mass Spectrum Analysis;Measurement;Metabolic;metabolic imaging;Metabolic Pathway;Molecular;Monitor;mutant;Mutate;Mutation;neuro-oncology;Nivolumab;Outcome;Oxidative Phosphorylation;Participant;Patients;peripheral blood;Pharmacotherapy;phase 1 study;Phase II Clinical Trials;Phenotype;preclinical study;Process;programs;Proliferating;Protocols documentation;Pyruvate;Research;Resources;response;Sampling;Scanning;Solid Neoplasm;Technology;Testing;Therapeutic;tool;treatment response;tumor;Tumor Tissue;United States National Institutes of Health;Warburg Effect

PROJECT_TITLE: Understanding IDH mutant gliomas


PI_NAMEs: YANG, JAMES C (contact)

PROJECT_TERMS: Affinity;Alleles;Antigens;Blood;BRAF gene;Cells;chemotherapy;China;Clinical;Codon Nucleotides;Collaborations;Common Neoplasm;DNA Sequence Alteration;engineered T cells;Epidermal Growth Factor Receptor;Epitopes;Human;Immune;Immune response;Immune system;immunogenic;Immunologics;Interleukin-12;Interleukin-2;KRAS2 gene;Malignant Neoplasms;malignant phenotype;manufacture;Mutate;Mutation;neoantigens;novel;Oncogenes;Organoids;Patients;PIK3CA gene;Proteins;ras Oncogene;receptor;Receptor Signaling;Recurrence;Site;Specificity;Standardization;T cell response;T cell therapy;T-Cell Receptor;T-Lymphocyte;Therapy trial;TP53 gene;Transgenic Mice;tumor

PROJECT_TITLE: Identification and use of T-cell receptors recognizing common tumor mutations


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Neuroblastoma;Neurosciences;Pediatric;Pediatric Cancer;Rare Diseases

PI_NAMEs: ALDAPE, KENNETH  (contact)

PROJECT_TERMS: Brain;Brain Neoplasms;Case Series;Cells;Central Nervous System Neoplasms;Cerebrospinal Fluid;Characteristics;chemotherapy;Chromosome 14;chromosome 1q gain;chromosome 3 loss;Classification;Clinical;cohort;Computing Methodologies;Copy Number Polymorphism;Data;Diagnosis;Disease;DNA copy number;DNA Methylation;Embryonal Neoplasm of the CNS;Excision;experience;follow-up;genomic profiles;Genomics;Goals;Heterogeneity;Histologic;Human;Individual;Leptomeninges;Location;Machine Learning;Malignant neoplasm of central nervous system;Malignant Neoplasms;Methylation;Molecular;neoplastic cell;Neuroblastoma;Neuroepithelial Neoplasms;new technology;Oncogenic;Outcome;Papillary Neoplasm;Patients;Pineal Region Tumor;Publishing;Recurrence;Recurrent tumor;relapse patients;Reporting;response;Sampling;Series;single cell analysis;Synaptophysin;Techniques;Transcript;tumor;tumor progression;virtual

PROJECT_TITLE: Single-cell DNA methylation analysis of human cancer


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Neurosciences;Precision Medicine;Rare Diseases

PROJECT_TERMS: Accounting;Adjuvant;Adjuvant Radiotherapy;Adjuvant Therapy;Algorithms;Behavior;Biological;Biological Markers;CDKN2A gene;Cell Cycle;Cessation of life;Clinical;cohort;Data Set;Development;Dimensions;Disease;DNA;DNA Methylation;epigenome;Excision;experience;Genes;Genomics;Goals;Heterogeneity;Hypermethylation;Immunohistochemistry;individual patient;interactive tool;Intracranial Neoplasms;Learning;Location;Maps;meningioma;Metadata;Methylation;methylome;Molecular;mRNA Expression;Mutation;Nomograms;Operative Surgical Procedures;outcome prediction;Pathway interactions;Patient Selection;Patient-Focused Outcomes;Patients;personalized medicine;Population;prevent;prognostic;Radiation;Recurrence;Recurrent tumor;response;Role;standard of care;Subgroup;Therapeutic;Time;transcriptome sequencing;transcriptomics;tumor;tumor progression;Validation;Visualization

PROJECT_TITLE: Development and validation of a predictor of meningioma recurrence