NIH_SPENDING_CATS: Mental Health;Neurosciences;Pediatric;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

PHR: Public Health Relevance While the underlying etiology/pathophysiology remain unclear for a majority of human neuropsychiatric diseases, it has become clear that early developmental defects can be a significant contributor to behavioral sequelae later in life. Our proposal examines a poorly understood area of developmental neurobiology: neural circuit activity control of postnatal neural stem cell proliferation and differentiation. We will focus on a newly identified neural circuit, specifically innervating the lateral ventricular neurogenic niche in the postnatal brain, and believe these studies will advance our understanding of how neuronal activity in the brain can modulate neurogenesis during development, as well as provide important insights into their potential changes in disease states.

PI_NAMEs: YIN, HENRY  (contact)

PROGRAM_OFFICER_NAME: KISHORE, SANDEEP

PROJECT_TERMS: Action Potentials;Anterior;Antimitotic Agents;Area;Astrocytes;Behavioral;Behavioral Paradigm;Biological Models;Birth;Brain;Brain region;Cell Differentiation process;Cell Maintenance;Cells;cholinergic;cholinergic neuron;cingulate cortex;Coupling;Cues;Defect;Development;developmental neurobiology;Disease;Environment;Etiology;experimental study;extracellular;Functional disorder;Glial Fibrillary Acidic Protein;Health;Housing;Human;in vivo;insight;Interneurons;Knock-in;Knowledge;Lateral;lateral line;lateral ventricle;Life;Maps;Measures;Mediating;Molecular;Mus;nerve stem cell;neural circuit;neural network;Neuroanatomy;neurogenesis;neuronal patterning;Neurons;Neurophysiology - biologic function;neuropsychiatric disorder;neuroregulation;newborn neuron;novel;optogenetics;Pathway interactions;Pattern;Play;Population;postnatal;postnatal human;postsynaptic;Process;Production;progenitor;programs;Property;public health relevance;Rabies;Radial;Reagent;Research;Resistance;Resolution;Rodent;Role;Signal Transduction;stem cell differentiation;stem cell fate specification;stem cell proliferation;Stimulus;Subependymal;Testing;thrombospondin 4;transcriptomics;Ventricular

PROJECT_TITLE: Neural Circuit Control of Postnatal Quiescent Neural Stem Cell Activation


ADMINISTERING_IC: DK

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Clinical Research;Diabetes

ORG_CITY: BOSTON

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: JOSLIN DIABETES CENTER

ORG_STATE: MA

PI_NAMEs: KULKARNI, ROHIT N. (contact)

PROJECT_TERMS: Area;Award;base;Biomedical Research;Boston;Clinical;Contingency Fund;Data;design;Diabetes Mellitus;experience;Extramural Activities;Faculty;Fostering;Funding;Goals;Grant;Guidelines;innovation;Institution;Investigation;Massachusetts;Mentors;Metabolism;Methods;Nonprofit Organizations;novel;Paper;Pathogenesis;Peer Review;programs;Publications;Recommendation;recruit;Research;Research Personnel;Research Support;Science;success;Talents;Technology;Time;Translating;United States National Institutes of Health

PROJECT_TITLE: Pilot and Feasibility Program


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Machine Learning and Artificial Intelligence;Mental Health;Neurosciences

ORG_CITY: ATLANTA

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: GEORGIA STATE UNIVERSITY

ORG_STATE: GA

PI_NAMEs: PLIS, SERGEY  (contact)

PROGRAM_OFFICER_NAME: FERRANTE, MICHELE

PROJECT_TERMS: Address;Adoption;Algorithms;base;Biological Markers;Brain;brain based;Brain Diseases;Brain imaging;Brain region;causal model;Cognitive;Communication;Communities;Computer software;Data;Data Collection;Data Set;diagnostic tool;Diffusion Magnetic Resonance Imaging;Disease;disease model;Disparate;diverse data;dynamic system;Electroencephalography;Environment;experimental study;Friends;Functional disorder;Functional Magnetic Resonance Imaging;Goals;Image;imaging modality;improved;Individual;insight;Knowledge;Learning;learning algorithm;learning network;learning strategy;Link;machine learning method;Magnetic Resonance Imaging;Maps;Measurement;Measures;member;Mental disorders;Methods;Mind;Modality;Modeling;multimodal data;multimodal neuroimaging;multimodality;neural;neural circuit;neuroimaging;Neurosciences;novel;Output;predictive tools;Psyche structure;psychologic;Research;Research Proposals;Sample Size;Sampling;Schizophrenia;Scientific Advances and Accomplishments;Scientist;Signal Transduction;Speed;Structure;success;System;Techniques;Testing;theories;Uncertainty;virtual

PROJECT_TITLE: CRCNS: Multimodal Dynamic Causal Learning for Neuroimaging


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Disorders;Nanotechnology;Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: CHICAGO

ORG_DEPT: NEUROLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative Spinocerebellar ataxia type 1 (SCA1) is a rare autosomal dominant neurodegenerative disorder for which there is no treatment. We have discovered that the angiogenic cytokine vascular endothelial growth factor (VEGF) is a promising treatment strategy given that recombinant VEGF considerably mitigates the disease phenotype in a mouse preclinical model. Since recombinant VEGF has significant limitations for use in the clinic, we are optimizing a VEGF mimetic nanoparticle approach to move forward in translating a VEGF-based therapy to human patients.

PI_NAMEs: OPAL, PUNEET  (contact);STUPP, SAMUEL I

PROGRAM_OFFICER_NAME: ROOF, REBECCA

PROJECT_TERMS: Ablation;Affect;angiogenesis;aqueous;ataxin-1;Autopsy;autosome;Behavioral;Benchmarking;Biological Assay;Brain;Brain Stem;CAG repeat;Central Nervous System;Cerebellar Ataxia;Cerebellar degeneration;Cerebellum;Cerebrospinal Fluid;Chemistry;Clinic;comparative efficacy;Confocal Microscopy;cost;cytokine;design;Disease;disease model;disease phenotype;Drug Kinetics;efficacy evaluation;Elements;Endothelial Cells;Endothelial Growth Factors Receptor;Engineering;Environment;Exhibits;experience;experimental study;Formulation;Freedom;Gadolinium;gain of function;Glutamine;Goals;Health;Hippocampus;Histologic;Human;human model;immunogenic;improved;In Vitro;in vivo;Inductively Coupled Plasma Mass Spectrometry;Inflammation;Inherited;Injections;Intellectual Property;Knock-in Mouse;Label;laser spectrometry;Length;Magnetic Resonance Imaging;manufacture;Measures;Medicine;Metals;Methods;Microscopy;middle age;mimetics;Modeling;Monitor;Motor;mouse model;Mus;mutant;nano;nanoparticle;Nanostructures;nanotherapy;Nature;Nerve Degeneration;Neurodegenerative Disorders;Neurons;neurovascular;novel;particle;Pathologic;Patients;Penetration;peptide amphiphiles;peptidomimetics;Phase;Phenotype;Physiological;polyglutamine;Pre-Clinical Model;Process;Property;Proteins;Recombinant Vascular Endothelial Growth Factor;Repression;Resolution;Sampling;Spatial Distribution;Spinal Cord;Symptoms;Techniques;Technology;Testing;Therapeutic;Therapeutic Agents;Time;Toxic effect;Translating;treatment strategy;Trinucleotide Repeat Expansion;Tumorigenicity;Type 1 Spinocerebellar Ataxia;Vascular Endothelial Growth Factors;VEGFA gene;Visualization;Work

PROJECT_TITLE: VEGF-Mimetic Supramolecular Nanoparticles for Treating Spinocerebellar Ataxia Type 1

STUDY_SECTION: NSD

STUDY_SECTION_NAME: Neurological Sciences and Disorders B Study Section[NSD-B]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: MAYWOOD

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: LOYOLA UNIVERSITY CHICAGO

PHR: Project Narrative Infections caused by Pseudomonas aeruginosa are a worldwide public health concern. A continued increase in antibiotic resistance along with limited understanding of how P. aeruginosa causes severe and invasive disease reinforce our need to develop better treatment options. This proposal will investigate a novel mechanism by which P. aeruginosa overcomes host barriers to disease with the goal of identifying new areas for the rational design of therapeutics that augment the ability of the immune system to eliminate the infection.

PI_NAMEs: ALLEN, JONATHAN P (contact)

PROGRAM_OFFICER_NAME: ERNST, NANCY L

PROJECT_TERMS: Affect;Alleles;antagonist;Antibiotic Resistance;Area;Attenuated;Bacteremia;Bacteria;bacterial resistance;Bacterial Toxins;C-terminal;Cell Survival;Cells;Characteristics;Clinical;Code;combat;Common Core;comparative genomics;Complex;cytotoxicity;Data;Defect;Disease;Disease Progression;enhancing factor;Escherichia coli;Eukaryotic Cell;Excretory function;Exotoxins;Genes;Genome;Genomic approach;Goals;Grant;Growth;Health Care Costs;health organization;Healthcare;Hela Cells;high risk;immune activation;Immune system;In Vitro;Incidence;Infection;Inflammation;insight;interest;Intoxication;Laboratories;Lactate Dehydrogenase;Length of Stay;Luciferases;Measures;Mediating;microorganism;Modeling;Molecular;mortality risk;Multi-Drug Resistance;multidrug-resistant Pseudomonas aeruginosa;Mus;mutant;Mutation;new therapeutic target;novel;novel therapeutics;Organism;Outcome;Pathogenesis;Pathogenicity;Pathway interactions;Patients;Pneumonia;programs;Prokaryotic Cells;Property;Proteins;Pseudomonas aeruginosa;Pseudomonas aeruginosa infection;Public Health;Pyocyanine;rational design;Reporter;Reporting;Research;resistant strain;Role;Sampling;stem;Surface;System;targeted treatment;Tertiary Protein Structure;Testing;Therapeutic;Therapeutic Agents;Therapeutic Intervention;Toxic effect;Toxin;trait;Transfection;Transfer RNA;Type III Secretion System Pathway;Virulence;Virulence Factors;Virulent;Work

PROJECT_TITLE: Contribution of CdiA to Pseudomonas aeruginosa pathobiology

STUDY_SECTION: HIBP

STUDY_SECTION_NAME: Host Interactions with Bacterial Pathogens Study Section[HIBP]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cardiovascular;Clinical Research;Heart Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pediatric;Pediatric Cardiomyopathy;Prevention;Rare Diseases

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: Hypertrophic cardiomyopathy (HCM) is the most common genetic heart disease, affecting as many as 1:200 individuals in the general population. HCM, initially described in the context of sudden cardiac death (SCD), is commonly associated with heart failure (HF) and atrial fibrillation (AF). The goal of this proposal is to develop novel risk stratification paradigms by leveraging recent advances in artificial intelligence (AI) to improve HCM patient management. The premise of the study is that AI provides a promising solution to intelligently extract and combine imaging and non-imaging markers of adverse cardiovascular events in HCM patients.

PI_NAMEs: MARON, MARTIN S;NEZAFAT, REZA  (contact)

PROGRAM_OFFICER_NAME: ANAYA, GABRIEL

PROJECT_TERMS: Ablation;Affect;Alcohols;Ambulatory Monitoring;Arrhythmia;Artificial Intelligence;Atrial Fibrillation;Behavior;Cardiac;cardiovascular imaging;Cardiovascular system;Caring;Clinical;Clinical Markers;clinically significant;cohort;Computing Methodologies;convolutional neural network;Data;Data Set;deep learning;deep learning model;Echocardiography;Electronic Health Record;Event;explainable artificial intelligence;follow-up;Functional disorder;Gadolinium;General Population;Genetic;Genetic Diseases;genetic information;genetic testing;Goals;Heart Diseases;Heart failure;high risk;Hypertrophic Cardiomyopathy;Image;imaging biomarker;imaging modality;Implantable Defibrillators;improved;Individual;Left Ventricular Outflow Obstruction;Logistic Regressions;Medical center;Modeling;mortality;mortality risk;Natural History;novel;Operative Surgical Procedures;Outcome;Patients;Performance;Phenotype;Play;Prevention;preventive intervention;primary outcome;prognostic;prophylactic;Quality of life;radiomics;Reporting;Research;Resolution;Risk;Risk Marker;risk prediction model;Risk Reduction;risk stratification;Role;secondary outcome;Statistical Data Interpretation;Stroke;stroke risk;sudden cardiac death;Symptoms;Techniques;Therapeutic;Tissues;Training;Transplantation;Universities

PROJECT_TITLE: Cardiac MR-Based Risk Stratification for Heart Failure and Atrial Fibrillation in HCM


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics

ORG_CITY: HANOVER

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: PROJECT NARRATIVE Wnt signaling is a biological pathway that allows cells to communicate and to coordinate their behavior during animal development, tissue maintenance, and regeneration. It is also often dysregulated across a wide variety of human diseases. We are working to discover the mechanisms that allow Wnt signals to induce the activation of genes and thereby regulate changes in cell growth and differentiation. Our discoveries will be applicable to new therapeutic strategies that regulate signaling in Wnt-driven developmental disorders and cancers.

PI_NAMEs: AHMED, YASMATH  (contact)

PROGRAM_OFFICER_NAME: XU, JIANHUA

PROJECT_TERMS: Adenosine Diphosphate Ribose;Animals;Behavior;beta catenin;Biochemical;Biological;Biological Assay;Cell Differentiation process;cell growth;Cell Proliferation;Cells;Collaborations;Colorectal Cancer;combat;Communication;Complex;design;Development;developmental disease;Disease;Dissection;Drosophila genus;Gene Activation;Genetic;Genetic Transcription;genome wide screen;Goals;Homeostasis;human disease;in vivo;in vivo Model;innovation;Knowledge;Laboratories;Maintenance;Malignant Neoplasms;Mass Spectrum Analysis;Membrane;Modeling;Molecular;Monitor;Natural regeneration;novel therapeutic intervention;Nuclear;Pathway Analysis;Pathway interactions;Phosphotransferases;Polymerase;Post-Translational Protein Processing;Predisposition;Productivity;programs;receptor;Receptor Activation;reconstitution;Research;Research Personnel;Role;Scaffolding Protein;Signal Transduction;Signal Transduction Pathway;Tankyrase;therapeutic target;Tissues;Tumor Suppressor Proteins;ubiquitin ligase;WNT Signaling Pathway;Work

PROJECT_TITLE: Genetic and Molecular Dissection of Wnt Pathway Activation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


ED_INST_TYPE: OVERALL MEDICAL

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Brain Disorders;Neurosciences

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE Astrocytes serve critical roles in neuronal circuit maturation by regulating the formation and elimination of neuronal synapses, as well as circuit maintenance by tightly controlling ionic balance and neurotransmitter recycling. We propose to investigate how an evolutionarily conserved, astrocyte-enriched protein, DBI, regulates the development and physiology of astrocytes and controls proper function of the neural circuitry using both fruit flies and zebrafish as model organisms.

PI_NAMEs: HEO, DONGEUN  (contact)

PROGRAM_OFFICER_NAME: LAVAUTE, TIMOTHY M

PROJECT_TERMS: Address;Affinity;Anxiety Disorders;Astrocytes;Autophagocytosis;Behavioral Assay;Benzodiazepines;Binding;Binding Sites;Biological Assay;Brain;Buffers;Cells;Central Nervous System;Cholesterol;Complex;Cytoskeleton;Data;density;Development;Diazepam;Diazepam Binding Inhibitor;Drosophila genus;Epilepsy;Equilibrium;Exhibits;extracellular;Functional disorder;genetic approach;genome editing;Growth;Homeostasis;Human;Image;in vivo;in vivo imaging;insight;Investigation;ionic balance;Larva;Ligands;loss of function;Maintenance;Mammals;Mediating;Mitochondria;mitochondrial permeability transition pore;model organism;Molecular;Molecular Genetics;Morphogenesis;Morphology;Mus;mutant;Names;Nervous System;nervous system development;neural circuit;Neurodevelopmental Disorder;Neuroglia;neuronal circuitry;Neurons;Neuropeptides;Neurophysiology - biologic function;neurotransmission;Neurotransmitters;novel;Outer Mitochondrial Membrane;Physiology;Play;positive allosteric modulator;Process;Proteins;receptor;Receptor Signaling;Recycling;response;RNA Interference;Rodent;Role;Seizures;Signal Transduction;Signaling Protein;Site;Synapses;synaptic pruning;synaptogenesis;tool;treatment of anxiety disorders;Work;Zebrafish

PROJECT_TITLE: Investigating the role of diazepam binding inhibitor (DBI) in astrocytes and neural circuit maturation

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-2 Study Section [NST-2]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

ORG_CITY: COLLEGE PARK

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

ORG_STATE: MD

PHR: Project Narrative Physiological transport of fluid, molecules, proteins, and cells throughout the body is critical for homeostasis. While transport processes like cell migration and molecular passage across cellular barriers are well documented, less is known about transport across the interstitial tissue spaces and into lymphatic vessels, the natural conduit from peripheral tissues to draining lymph nodes, where the immune response is shaped. The proposed research program combines mucosal, lymphoid tissue, and lymphatic vessel physiology with engineering approaches, such as building relevant in vitro model systems and designing nanoparticle probes, to increase our understanding of protein, particulate, and other material transport across interstitial tissues and into lymphatic vessels.

PI_NAMEs: MAISEL, KATHARINA  (contact)

PROGRAM_OFFICER_NAME: KODURI, SAILAJA

PROJECT_TERMS: adaptive immune response;Address;Affect;Attention;Biological;Biological Models;Blood Vessels;cell motility;Cells;Communities;Computer Models;delivery vehicle;design;Diffusion;Disease;draining lymph node;Drug Delivery Systems;Drug Targeting;Edema;Engineering;extracellular;Extracellular Space;fluid flow;Homeostasis;Immune response;immunoregulation;in vitro Model;Inflammation;insight;interstitial;Knowledge;Light;Liquid substance;lymph nodes;Lymphatic;lymphatic circulation;lymphatic vessel;Lymphoid Tissue;Maintenance;Methods;model design;Modeling;Molecular;Mucous Membrane;nanoparticle;particle;Particulate;Peripheral;Physiological;Physiological Processes;Physiology;Process;programs;Proteins;Regulation;Research;Rheology;Shapes;Slice;Structure;Techniques;Therapeutic;Time;Tissues;tool;Transport Process;Vision;Work

PROJECT_TITLE: Regulation and modeling of transport across tissue barriers

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-R(55)R]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hearing Loss;Human Genome;Neurodegenerative;Neurosciences;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Rehabilitation

ORG_CITY: Aurora

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Hearing including analytic change  loss is a leading cause of disability in the United States and worldwide, affecting billions of people, individuals across age groups and those of Hispanic background. By using genomic technologies and techniques, this project will identify genetic variants as well as regions of the human genome that gene expression and function and cause hearing loss in Hispanic children.Results of this study will aid not only in the identification of causes of hearing loss and genetic counseling of families with hearing loss, but also in understanding the basic functions of the human ear and the discovery of new therapies for hearing loss.

PI_NAMEs: SANTOS-CORTEZ, REGIE LYN PASTOR (contact);YANG, IVANA V

PROGRAM_OFFICER_NAME: WATSON, BRACIE

PROJECT_TERMS: Admixture;Affect;Age;age group;Agrochemicals;Alleles;Animal Model;Architecture;Biological Markers;bisulfite;Blood;case control;causal variant;Chemicals;Child;Chile;Chinese;Clinical;clinical translation;Clustered Regularly Interspaced Short Palindromic Repeats;Cochlea;Cochlear Implants;Code;cohort;Complex;Copy Number Polymorphism;Country;Data;Defect;design;Detection;Dideoxy Chain Termination DNA Sequencing;disability;Disease;DNA;Ear;Eligibility Determination;empowerment;Enhancers;Environment;Environmental Risk Factor;Epigenetic Process;epigenome-wide association studies;epigenomics;Epithelial Cells;Ethnic Origin;Etiology;European;exome;exome sequencing;experience;Exposure to;Family;Filipino;follow-up;Follow-Up Studies;functional genomics;Gene Expression;gene function;Genes;Genetic;Genetic Counseling;genetic linkage analysis;Genetic Predisposition to Disease;Genetic Screening;genetic testing;genetic variant;genome sequencing;genome-wide;genome-wide analysis;Genomics;GJB2 gene;Goals;Hearing;hearing impairment;hearing loss treatment;hereditary hearing loss;high risk;Hispanic;Hispanic Americans;Hispanic ancestry;Hispanic Populations;Human;Human Genetics;Human Genome;Hypermethylation;improved;Individual;Industrial Waste;Industrialization;International;Knockout Mice;Knowledge;Labyrinth;Latino;Lead levels;Low Prevalence;Maps;Methods;Methylation;methylome;Mexico;Minority Groups;Modeling;Modification;Mus;Mutation;Neuroepithelial Tissue;next generation sequence data;Nicaragua;Nicaraguan;novel;novel therapeutics;Nucleic Acid Regulatory Sequences;Otology;Outcome;Pathway Analysis;Patients;Persons;Philippines;Population;Prevalence;proband;Process;Productivity;promoter;Proteins;Protocols documentation;Quantitative Trait Loci;RB1 gene;Recording of previous events;recruit;Research Personnel;Risk Factors;Saliva;Sampling;Secondary Prevention;segregation;Sensorineural Hearing Loss;Sensory;sex;Shapes;Signal Transduction;Site;Structure;Technology;technology/technique;Temporal bone structure;Testing;Therapeutic;therapy development;Tissues;translational genetics;transmission process;Tumor Suppressor Genes;United States;Untranslated RNA;Validation;Variant;whole genome;Zebrafish

PROJECT_TITLE: Genetic and epigenomic determinants of hearing loss in Hispanic populations

STUDY_SECTION: NAME

STUDY_SECTION_NAME: Neurological, Aging and Musculoskeletal Epidemiology Study Section[NAME]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: NOVATO

ORG_NAME: BUCK INSTITUTE FOR RESEARCH ON AGING

ORG_STATE: CA

PHR: PROJECT NARRATIVE This project will identify how gene networks are regulated in the healthy brain and how they become dysregulated in aging and Alzheimer’s disease. This study will advance our understanding of the mechanisms responsible for brain aging and neurodegeneration, and may lead to therapies to treat diseases such as Alzheimer’s.

PI_NAMEs: WEBB, ASHLEY E (contact)

PROGRAM_OFFICER_NAME: GRAY, ERIN EMILY

PROJECT_TERMS: Ablation;age effect;age-related disease;Aging;aging brain;aging population;Alzheimer's Disease;ATAC-seq;biological adaptation to stress;Biological Assay;Brain;Caenorhabditis elegans;Cell Physiology;Cells;Cellular Stress;ChIP-seq;Chromatin;Chromatin Remodeling Factor;Data;Disease;Disease Progression;epigenomics;Etiology;extend lifespan;Family;FOXO3A gene;functional genomics;Future;Gene Expression;gene network;Genes;Genetic Transcription;genome-wide;Genomics;Goals;hallmarks of aging;Health;healthy aging;Homeostasis;Human;improved;Individual;induced pluripotent stem cell;insight;Insulin;Intervention;Invertebrates;Link;Longevity;Mediating;Meta-Analysis;Metabolism;model organism;multiple omics;Mus;Nature;Nerve Degeneration;nerve stem cell;Neurodegenerative Disorders;Pathology;Pathway interactions;Physiological;Population;preservation;prevent;programs;Publishing;Quality Control;Rodent;Role;Signal Transduction;Single Nucleotide Polymorphism;Site;stem cell homeostasis;stem cells;Testing;therapeutic candidate;therapeutic target;Time;Tissues;transcription factor;Transcription Factor AP-1;transcriptome sequencing;Work

PROJECT_TITLE: Pioneer transcription factors in aging and neurodegeneration

STUDY_SECTION: CMAD

STUDY_SECTION_NAME: Cellular Mechanisms in Aging and Development Study Section[CMAD]


ORG_CITY: AUSTIN

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

ORG_STATE: TX

PHR: PROJECT NARRATIVE Human carcinomas and transport disorders are characterized by the dissolution of cellular junctions, the attachment points that link cells together and to the surrounding tissue. One possible therapeutic target for these diseases is the cytoskeleton, which is abundant in healthy cell junctions but dysregulated during disease progression. This proposal seeks to develop a molecular toolkit for controlling the cytoskeleton with specificity at cell junctions, thereby reducing toxic side-effects and offering the possibility of reinforcing healthy junctions to treat cancer and transport disorders.

PI_NAMEs: BELARDI, BRIAN  (contact)

PROGRAM_OFFICER_NAME: RIGAS, MARC

PROJECT_TITLE: A Molecular Toolkit for Controlling and Probing Cell Junction-Actin Interactions

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-H(55)R]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Influenza;Pneumonia and Influenza

ORG_CITY: COLUMBIA

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

ORG_STATE: MO

PHR: Project Narrative Influenza virus continues to pose a worldwide threat to humans, requiring identification of new cellular targets to regulate viral pathogenicity for its control. Sphingosine 1-phosphate (S1P)-metabolizing enzymes were found to function as mediators that control important cellular or disease processes, which prompted us to investigate roles of the S1P-metabolizing enzymes during influenza virus infection. Investigating the molecular mechanisms by which S1P-metabolizing enzymes regulate host defense or signaling pathways to impact influenza virus pathogenesis comprises a promising means for developing novel therapeutic interventions to remedy influenza.

PI_NAMEs: HAHM, BUMSUK  (contact)

PROGRAM_OFFICER_NAME: BOZICK, BROOKE ALLISON

PROJECT_TERMS: Acceleration;Affect;Animal Model;anti-influenza;Attenuated;Biological Process;cellular targeting;Data;Death Rate;design;Development;Disease;Environment;Enzymes;Epithelial Cells;Event;Exhibits;Foundations;Goals;Health;Host Defense;Host Defense Mechanism;Human;Impairment;In Vitro;in vivo;in vivo Model;Infection;Influenza;influenza infection;influenzavirus;Innate Immune Response;Integration Host Factors;Interferon Type I;Interferons;Knockout Mice;Knowledge;lipid mediator;Mediating;Mediator;Molecular;Morbidity - disease rate;Mus;novel;novel therapeutic intervention;Outcome;Pathogenesis;Pathogenicity;Pathway interactions;Process;Reporting;Research;response;Role;Signal Pathway;Signal Transduction;Sphingolipids;Sphingosine;sphingosine 1-phosphate;sphingosine kinase;sphingosine-1-phosphate lyase;targeted treatment;Therapeutic;Ubiquitination;Viral;Viral Pathogenesis;Viral Physiology;Virus;Virus Diseases;virus host interaction;Virus Replication

PROJECT_TITLE: Interplay between influenza virus and S1P-metabolizing enzymes

STUDY_SECTION: VIRB

STUDY_SECTION_NAME: Virology - B Study Section[VIRB]


NIH_SPENDING_CATS: Aging;Neurosciences

ORG_DEPT: PHYSICS

ORG_NAME: EMORY UNIVERSITY

PHR: NARRATIVE Physiological actin dynamics are indispensable for normal function in many important processes such as cell migration, wound healing and the immune process of phagocytosis. Our proposed research is focused on elucidating molecular mechanisms underlying actin dynamics in living cells. Understanding of these mechanisms will pave the way for development of new therapies to combat diseases like Amyotrophic Lateral Sclerosis (ALS), metastatic cancer and neurological disorders (e.g. Alzheimer's disease and Parkinson's diseases).

PI_NAMEs: SHEKHAR, SHASHANK  (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TERMS: Acceleration;Actin-Binding Protein;Actins;Alzheimer's Disease;Amyotrophic Lateral Sclerosis;Behavior;Binding;Binding Proteins;Biochemical;Biophysics;Cell division;cell motility;Cells;cofilin;combat;Complex;Deformity;depolymerization;Development;developmental disease;Disease;Disseminated Malignant Neoplasm;Ecosystem;Endocytosis;Enhancers;experimental study;Filament;Goals;Growth;Human;Immune;Individual;Limb structure;mathematical model;mechanical force;mechanical signal;Microfilaments;Microfluidics;Microscopic;Molecular;molecular imaging;Nervous System Disorder;Neurologic;novel therapeutics;Parkinson Disease;Phagocytosis;Physiological;Process;Proteins;Regulation;Research;Signal Transduction;single molecule;Site;Structure;Vision;Work;wound healing

PROJECT_TITLE: Multicomponent mechanochemical regulation of actin filament end dynamics

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-V(55)R]


ADMINISTERING_IC: HD

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Fragile X Syndrome;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Rare Diseases

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: PROJECT NARRATIVE  Speech production deficits and behavioral inflexibility are among the most functionally disabling behavioral features of Fragile X Syndrome (FXS), but continue to lack effective treatments due to limited mechanistic understanding. The proposed study will investigate speech production and behavioral flexibility deficits in FXS using performance-based tasks during high-density electroencephalography (EEG) to measure fronto-temporal and fronto-parietal circuits in individuals with FXS, respectively. These electrophysiological studies have the potential to elucidate atypical local neural circuity and its integration in widely distributed brain networks underlying these behavioral features, thus this work will provide critical insight into underlying neurophysiological mechanisms and will assist in the identification of disorder-relevant biomarkers, ultimately, helping to speed treatment development to improve speech production and behavioral flexibility in FXS.

PI_NAMEs: SCHMITT, LAUREN  (contact)

PROGRAM_OFFICER_NAME: KAU, ALICE S

PROJECT_TERMS: Acceleration;Adult;Age;Animal Model;Anterior;Area;Attenuated;behavior observation;Behavioral;behavioral phenotyping;behavioral response;Biological;Biological Markers;biomarker discovery;biomarker identification;Brain;career;Child;Clinical;clinical phenotype;Clinical Psychology;Cognition;Cognitive;cognitive task;Coupling;Data;density;Development;Developmental Delay Disorders;Disabling;Disease;drug discovery;effective therapy;effectiveness measure;Electroencephalography;Electrophysiology (science);Ensure;Event-Related Potentials;Executive Dysfunction;Faculty;Family;flexibility;Fragile X Syndrome;frontal lobe;Functional impairment;Goals;Housing;Hypersensitivity;improved;Individual;Inherited;insight;Intellectual functioning disability;K-Series Research Career Programs;Knowledge;Language;language impairment;Learning;Learning Disabilities;Link;Measures;Mentors;Mentorship;Mus;neural;Neurocognitive;Neurocognitive Deficit;Neurodevelopmental Disorder;neurophysiology;Neuropsychology;Neurosciences;Outcome;Parents;Parietal Lobe;Participant;Patients;Performance;Phase;preservation;Production;programs;recruit;reduce symptoms;repetitive behavior;Reporting;Research;Research Personnel;research study;Research Support;Research Training;Resources;response;Rest;Reversal Learning;Sampling;Seminal;Sensory;Severities;sex;skills;social anxiety;social communication;Speech;Speed;Standardization;System;Testing;therapy development;Training;Training Programs;Translational Research;Treatment Effectiveness;United States National Institutes of Health;Validation;Work

PROJECT_TITLE: Electrophysiological Biomarkers of Neurocognitive Deficits in Fragile X Syndrome

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Biobehavioral and Behavioral Sciences Study Section[CHHD-H]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: Auburn

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: AUBURN UNIVERSITY AT AUBURN

ORG_STATE: AL

PHR: PROJECT NARRATIVE G‐RISE at Auburn University is designed as an umbrella to enhance diversity in graduate programs focused on doctoral degrees in the biomedical sciences. Programmatic activities are focused on recruiting, admitting, and supporting six highly qualified students yearly from underrepresented groups through multiple mechanisms, with common threads of inclusive excellence and mentoring constellations. Given the history of racial inequities and the demographic composition of the region, G‐RISE at Auburn will focus on African‐American, Latinx, and Native American students in recruiting efforts, but will welcome all applicants.

PI_NAMEs: CLAYTON, TAFFYE BENSON;RUSSELL, MELODY L;SMITH, BRUCE F. (contact)

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TERMS: Universities

PROJECT_TITLE: G-RISE at Auburn University

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - D[TWD-D]


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_CITY: COLD SPRING HARBOR

ORG_NAME: COLD SPRING HARBOR LABORATORY

ORG_STATE: NY

PHR: PROJECT NARRATIVE CSHL Laboratory Course in Single Cell Analysis This application seeks funds to support an advanced cell & molecular lab-based short course at Cold Spring Harbor Laboratory, New York. The goal of this two-week course is to teach students cutting-edge wet-lab approaches for single cell analysis, and to provide familiarity with basic bioinformatic approaches to single cell data. Modules of the course will be taught by scientists with expertise in distinct areas of single cell analysis. Trainees include advanced graduate students, postdoctoral researchers and young faculty from throughout the United States and abroad. The selection process for entry into this course is highly competitive, and trainees leave the course armed with new techniques, know-how and potential collaborators to apply to their own areas of research. A significant proportion of trainees subsequently undertake basic or applied research in diseases of child health and/or human development. Methods and concepts taught in the course are disseminated to the wider research community through the publication of laboratory manuals and online resources.

PI_NAMEs: STEWART, DAVID J. (contact)

PROGRAM_OFFICER_NAME: STEIN, KATHRYN K

PROJECT_TERMS: Applied Research;Area;Attention;Basic Science;Bioinformatics;biological research;Biomedical Research;Cell Separation;Cells;Cellular biology;Child Health;Collaborations;Communities;Course Content;course module;Data;Data Analytics;Disease;DNA analysis;Educational process of instructing;Electrophysiology (science);Ensure;Environment;experience;Faculty;Familiarity;forging;Funding;Future;Genomic DNA;Goals;graduate student;Home;Human Development;Image;Individual;Institution;instructor;interest;Laboratories;laboratory curriculum;laboratory manuals;lecturer;Libraries;Mainstreaming;Mass Spectrum Analysis;medical specialties;member;metabolomics;Methodology;Methods;mid-career faculty;Molecular;Molecular Analysis;Molecular Biology;Neurosciences;New York;online resource;Participant;Pathologic;Pharmacology;Physicians;Postdoctoral Fellow;Preparation;Process;programs;Proteomics;Publications;Reporting;Research;Research Personnel;Role;Scientist;Series;single cell analysis;single cell sequencing;single molecule;single-cell RNA sequencing;Students;Techniques;Time;Tissues;Training;Training Programs;transcriptome sequencing;United States;Update;Western Blotting;Work;X-Ray Tomography

PROJECT_TITLE: CSHL Single Cell Analysis Course (2023-2027)

STUDY_SECTION_NAME: Developmental Biology Study Section[CHHD-C]


ADMINISTERING_IC: NR

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Nutrition;Obesity;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

PHR: Project Narrative Difficulties of labor initiation and progression are responsible for much of the injury and death seen around the time of birth in both women and their neonates, and Black women are much more likely than white women to experience injury and death around the time of birth. The proposed project will measure social determinants of health, pregnancy lifestyle, and blood samples in two groups of Black women who receive prenatal care in either a freestanding birth center or a hospital clinic to better understand how pregnancy experiences and health influence labor outcomes. The purpose of this project is to promote health and eliminate health disparities through a better understanding of the physiology of labor dysfunction.

PI_NAMEs: CARLSON, NICOLE S. (contact)

PROGRAM_OFFICER_NAME: GIVENS-BRADLEY, SHANNON SHAREE

PROJECT_TERMS: adiponectin;Adipose tissue;Affect;Animals;Anxiety;Behavioral;Biological;biomarker identification;Birth;Birthing Centers;Black Populations;Black race;black women;Blood;Blood specimen;Body Composition;Body fat;Body mass index;Caring;Cell membrane;Cellular Membrane;Cesarean section;Cessation of life;Chronic;Clinics and Hospitals;cohort;Collection;Consumption;Data;Deposition;Developed Countries;Diet;Discrimination;Disparity;Early Diagnosis;early pregnancy;electric impedance;Event;Exhibits;experience;Fatty acid glycerol esters;Fatty Acids;Fiber;First Pregnancy Trimester;Functional disorder;Future;Health;health disparity;Health Promotion;Hormones;hospital care;Hospitals;improved;Individual;Induced Labor;Inflammation;Injury;Insulin Resistance;Intake;Intervention;Investigation;Labor Onset;Late pregnancy;Leptin;Life Style;Link;lipid metabolism;lipidomics;Lipids;Literature;Maternal Behavior;maternal morbidity;Maternal Mortality;maternal obesity;Measurement;Measures;Mental Depression;Metabolic;Metabolic Pathway;Metabolism;Midwife;Modeling;Morbidity - disease rate;multidisciplinary;neighborhood safety;neonate;Non obese;Nonesterified Fatty Acids;Not Hispanic or Latino;nutrition;Nutritional;Obesity;Outcome;Pathway Analysis;Pathway interactions;Pattern;perceived discrimination;perceived stress;Perinatal;Physical activity;Physiological;Physiology;Polyunsaturated Fatty Acids;Postpartum Period;predictive marker;Pregnancy;Pregnancy Complications;pregnancy health;Pregnancy Outcome;pregnancy related death;prenatal;Prenatal care;prenatal influence;Prevention;Questionnaires;racial disparity;Recovery;recruit;research study;Risk;Risk Factors;Serum;social health determinants;Stress;Stressful Event;subcutaneous;System;Systems Biology;Technology;theories;Third Pregnancy Trimester;Time;Tissues;United States;Uterine Contraction;Uterus;White Women;Woman;Work

PROJECT_TITLE: Biologic Mechanisms of Labor Dysfunction: A Systems Biology Approach


NIH_SPENDING_CATS: Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Dissemination and Implementation Research;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Serious Mental Illness

ORG_CITY: PITTSBURGH

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Public Health Relevance We propose to confirm the ability of individuals with major depressive disorder (MDD) to increase and sustain activity of the amygdala during positive memory recall, and that this ability results in outcomes that are clinically relevant for those with the disorder. We expect this study to provide a non-pharmacological, non- invasive treatment to increase the processing of positive stimuli in patients with MDD, and will work with patients and providers to increase the likelihood of this intervention becoming available as a treatment option.

PI_NAMEs: YOUNG, KYM  (contact)

PROGRAM_OFFICER_NAME: RUDORFER, MATTHEW V

PROJECT_TERMS: Adopted;Affect;Alexithymias;Amygdaloid structure;Anhedonia;anti-depressive agents;Autobiography;Brain;Brain region;Clinical;clinical effect;Clinical Trials;clinically relevant;Communities;confirmatory clinical trial;confirmatory trial;Control Groups;Data;depressive symptoms;design;Diagnosis;Disease;Dissemination and Implementation;Double-Blind Method;efficacy evaluation;Emotional;Ensure;Evaluation;experimental group;Feedback;follow-up;Functional Magnetic Resonance Imaging;future implementation;Gender;Goals;hemodynamics;implementation determinants;improved;indexing;Individual;Intervention;intervention refinement;Literature;Major Depressive Disorder;Measures;Mediating;Memory;memory recall;Mental Depression;neurofeedback;novel therapeutics;Outcome;Participant;Patient Self-Report;Patients;Pharmaceutical Preparations;pharmacologic;Phase;Process;process evaluation;Provider;Proxy;psychologic;Public Health;public health relevance;Quality of life;Randomized;randomized, clinical trials;Recovery;reduce symptoms;response;Rest;Sampling;Scientist;Series;Signal Transduction;Specificity;stakeholder perspectives;Stimulus;success;symptomatic improvement;Symptoms;Time;Training;Translational Research;Treatment Efficacy;treatment response;Work

PROJECT_TITLE: Confirmatory Efficacy Clinical Trial of Amygdala Neurofeedback for Depression


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Infectious Diseases;Neurodegenerative;Neurosciences;Sexually Transmitted Infections

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Project Narrative Herpesviruses are ubiquitous human pathogens and their infection has been implicated in neurodegenerative diseases such as Alzheimer’s disease (AD). Aging and herpesvirus infection (as an environmental factor) may synergize to induce neurodegeneration, although our understanding concerning their interaction is incomplete. This proposal will investigate how aging and herpesvirus infection interact in normal and AD model mouse.

PI_NAMEs: FENG, PINGHUI  (contact)

PROGRAM_OFFICER_NAME: MARIC, MAJA

PROJECT_TERMS: Acceleration;Affect;age acceleration;age related neurodegeneration;Aging;aging brain;Alzheimer associated neurodegeneration;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease patient;American;anti aging;Biological Process;Brain;brain tissue;Cells;cofactor;Cognition;Collaborations;cytosolic receptor;deamidation;defined contribution;Dementia;Development;Disease;Economic Burden;Environmental Risk Factor;Enzymes;Epithelium;Etiology;exosome;General Population;genetic makeup;hallmarks of aging;Herpes Simplex Infections;Herpesviridae;Herpesviridae Infections;Herpesvirus 1;Homeostasis;Host Defense;Human;human old age (65+);human pathogen;Immune Evasion;Immunocompetent;Impairment;in vivo;Individual;Infection;Innate Immune Response;innovation;insight;interest;Laboratories;Late Onset Alzheimer Disease;latent infection;lytic replication;Mediating;Memory;Metabolic;Metabolism;Microbe;microbial;Modality;Molecular;mouse model;Mouse Strains;Mus;mutant;Natural Immunity;Nerve Degeneration;Neurodegenerative Disorders;Neurons;neurotropic;nicotinamide phosphoribosyltransferase;Outcome;pathogen;Pathogenesis;Pathway interactions;Patients;Pattern;Population;Prevention;Primary Infection;Process;Proteins;Resistance;Risk Factors;Role;Simplexvirus;social;Structure of trigeminal ganglion;synergism;Translating;Viral;Viral Physiology;Virion;Virus Replication;Work

PROJECT_TITLE: Explore roles of HSV-1 in Alzheimer's disease using mouse models

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


NIH_SPENDING_CATS: Bioengineering;Nanotechnology

ORG_CITY: NEW YORK

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: CITY COLLEGE OF NEW YORK

PHR: Project Narrative This works aims to study the role of inflammatory proteins in the development and progression of chronic disease. We will use an injectable fluorescent nanosensor network to quantify inflammatory proteins at the site of disease as well as throughout the body. We expect to understand the role of inflammation in chronic disease and to potentially discover new inflammatory signatures for different stages of each disease.

PI_NAMEs: WILLIAMS, RYAN MARTIN (contact)

PROGRAM_OFFICER_NAME: ZHAO, XIAOLI

PROJECT_TERMS: Acute;Animals;Autoimmune Diseases;Blood;Carbon;Cardiovascular Diseases;Cells;Chronic;Chronic Disease;Chronic Kidney Failure;Chronic Phase;Communicable Diseases;Coupled;cytokine;Cytokine Signaling;Data;design;Detection;Development;Disease;disease model;Disease Progression;Encapsulated;end stage disease;Ensure;Evaluation Research;Exhibits;Future;Hydrogels;Imaging Techniques;Immune response;Immunoassay;implantation;In Situ;Inflammation;Inflammatory;Inflammatory Response;Injectable;Injections;insight;Kinetics;Laboratories;Light;Location;Malignant Neoplasms;Measurement;Measures;minimally invasive;Modeling;molecular imaging;Mus;Musculoskeletal Diseases;nanosensors;Neurodegenerative Disorders;Organ;Pathogenesis;Proteins;rapid detection;Research Methodology;Rodent Model;Role;Scientist;sensor;Signal Transduction;Site;Specificity;Stains;System;systemic inflammatory response;technology validation;Time;Time Study;transcriptome sequencing;whole animal imaging;Work

PROJECT_TITLE: Integrating Real-Time Multi-System Cytokine Signaling in Chronic Disease


NIH_SPENDING_CATS: Clinical Research;Digestive Diseases;Food Allergies;Genetics;Nutrition;Pediatric;Prevention

ORG_DEPT: PEDIATRICS

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Narrative The persistence of food allergy depends on the continuous production of food-specific IgE antibodies by specialized plasma cells, and on long-lived memory B lymphocytes that maintain the supply of food-specific IgE plasma cells. We propose to determine if the memory B lymphocytes that react to food in allergic individuals have unique characteristics that facilitates their differentiation into IgE plasma cells producing disease-causing IgE antibodies.

PI_NAMEs: CUROTTO DE LAFAILLE, MARIA A (contact)

PROGRAM_OFFICER_NAME: DONG, GANG

PROJECT_TERMS: Affect;Affinity;Allergens;Allergic;Allergic Disease;Anaphylaxis;Antibodies;Antibody Response;Asthma;Atopic Dermatitis;atopy;B-Cell Activation;B-Lymphocytes;Basic Science;Blood;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Characteristics;Child;Childhood;clinical care;Clinical Research;comparative;Cytometry;Data;design;Development;Diphtheria Toxoid;Disease;Environment;Evolution;experimental study;Food;food allergen;Food Hypersensitivity;Food production;Food Supply;Generations;Genes;Goals;gut inflammation;Human;Hypersensitivity;IgE;IgG1;IL13RA1 gene;IL4R gene;Immune;Immunoglobulin Class Switching;Immunoglobulin G;In Vitro;Individual;Inflammatory;influenzavirus;Institution;Life;longitudinal analysis;Mediating;Mediator;Memory;Memory B-Lymphocyte;Milk;Modeling;Molecular Profiling;Mus;new therapeutic target;novel therapeutics;Pathogenicity;patient population;Phenotype;Plasma Cells;Population;Proliferating;Proteins;Publishing;Reaction;Research;Resolution;response;Risk;Risk Marker;Role;single-cell RNA sequencing;targeted treatment;Tetanus;tool;Transcript;transcriptomics;Vaccine Antigen;Viral;Viral Antigens

PROJECT_TITLE: B cell memory in human food allergy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIB-E(57)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Human Genome;Infectious Diseases;Neurodegenerative;Neurosciences;Sexually Transmitted Infections

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE Compelling data now link latent herpes virus infection and, in particular, viral reactivation in the brain to increased incidence of Alzheimer’s disease (AD), a nearly pandemic neurodegenerative disease for which there are no effective therapies. This proposal will investigate the cell type- specific effects of HSV1 RNAs in human AD brains and AD model systems by leveraging single- nucleus sequencing technologies as well as explore the hypothesis that the viral latency RNA transcripts (LATs) modulate transcriptional events in the host associated with AD. Further, we will elucidate a novel innate immune pathway that may contribute to HSV1-induced inflammation and neurotoxicity and characterize the distinct genomic actions as well as non- genomic protective properties of the HSV1 latency-associated transcripts that can be exploited as a prophylactic modality for AD.

PI_NAMEs: ROSENFELD, MICHAEL G (contact)

PROJECT_TERMS: abeta accumulation;abeta toxicity;Acute;Affect;Afferent Neurons;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease risk;Amyloid;Appearance;Astrocytes;Attenuated;Binding;Biological Models;Brain;brain cell;Cell Death;Cell Death Inhibition;Cell Nucleus;cell type;Cells;Chronic;Clinical;Collaborations;Data;Dementia;Deposition;Disease Progression;DNA;Ectopic Expression;effective therapy;Endogenous Retroviruses;Enhancers;Environmental Risk Factor;epidemiology study;Equilibrium;Etiology;Event;extracellular;Gene Expression;Gene Expression Profile;Gene Family;Genes;Genetic;Genetic Risk;Genetic Transcription;Genetic Variation;Genome;genome wide association study;genome-wide analysis;Genomics;Herpes Simplex Infections;Herpesviridae;Herpesviridae Infections;Herpesvirus 1;Human;human induced pluripotent stem cells;Impaired cognition;Incidence;Inflammation;Inflammatory;inflammatory milieu;innate immune pathways;Innate Immune Response;insight;Intervention;Investigation;Laboratories;latency associated transcript;latent infection;Licensing;Link;Lytic;Lytic Phase;Mediating;member;Methods;microbial;Microglia;Modality;Molecular;mouse model;mutant;Neurodegenerative Disorders;Neurofibrillary Tangles;Neuroglia;neuron loss;Neurons;neuropathology;neurotoxicity;NF-kappa B;non-genomic;novel;Nuclear Accidents;Nucleic Acid Regulatory Sequences;Organoids;pandemic disease;Pathogenesis;Pathologic Processes;Pathway interactions;Phosphotransferases;Pituitary Gland;Population;POU Domain;POU domain factors;Predisposition;preservation;Process;programs;Property;prophylactic;Proteins;reactivation from latency;Recurrence;Regulation;Regulatory Element;Reporting;risk variant;RNA;Role;Sampling;Sentinel;single nucleus RNA-sequencing;Specimen;Symptoms;Technology;Testing;Therapeutic;Transcript;Transcriptional Activation;transcriptome;Untranslated RNA;Viral;Viral Genome;Virus;Virus Latency;Zinc Fingers

PROJECT_TITLE: Revealing the roles of HSV1 lytic and latent transcripts in AD pathogenesis and therapy


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Depression;Mental Health;Neurodegenerative;Neurosciences;Prevention;Sleep Research

ORG_CITY: IOWA CITY

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Project Narrative The goal of these studies is to determine whether tau accumulation in serotonin neurons causes affective and sleep disturbances, leading to chronic sleep deprivation and hyperexcitability in serotonin neurons and accelerating the spread of tau pathology to the entorhinal cortex. The resulting loss of 5-HT input to the EC also enhances excitability of EC neurons that project to the hippocampus, promoting spread to this region and precipitating cognitive decline. Ultimately, this investigation may identify neural substrates underlying the early non-cognitive symptoms of AD which could lead to better treatments for this devastating disease.

PI_NAMEs: MARCINKIEWCZ, CATHERINE ANNE (contact)

PROGRAM_OFFICER_NAME: MACKIEWICZ, MIROSLAW

PROJECT_TERMS: Acceleration;Affective;affective disturbance;Age;age related neurodegeneration;Agreement;Alzheimer's Disease;American;Appearance;attenuation;Automobile Driving;Behavior;Behavioral;Behavioral Symptoms;Biological Assay;Brain;Brain region;Chronic;Clinical Data;Cognitive;Cognitive deficits;Data;Denervation;depressive behavior;depressive symptoms;Deterioration;Development;Disease;Disinhibition;dorsal raphe nucleus;early detection biomarkers;Early Diagnosis;Electroencephalography;Electrophysiology (science);entorhinal cortex;Etiology;Exhibits;Expectancy;Fiber;genetic manipulation;Goals;Hippocampus;hTau Mice;Human;Hyperactivity;Impaired cognition;in vivo;Individual;Induced Neurons;Intervention;Investigation;Measures;Mediating;Memory;Memory impairment;Mental Depression;Microinjections;mild cognitive impairment;Monitor;mouse model;Mus;mutant;Nerve Degeneration;neural;neural circuit;Neurobehavioral Manifestations;neurofibrillary tangle formation;Neurofibrillary Tangles;neuromechanism;neuronal excitability;Neurons;neuroprotection;Onset of illness;optogenetics;Pathology;Periodicity;Photometry;prevent;Quality of life;Receptor Signaling;Research;Risk;Role;Scanning;Selective Serotonin Reuptake Inhibitor;Serotonin;Serotonin Receptor 5-HT2A;Signal Transduction;Sleep;Sleep Deprivation;Sleep Disorders;Sleep disturbances;Sleep Fragmentations;sleep quality;Slice;Symptoms;Synapses;tau aggregation;tau Proteins;tau-1;Tauopathies;Testing;Three-Dimensional Imaging;transmission process

PROJECT_TITLE: Sleep and affective disturbances in the etiology of Alzheimer's disease

STUDY_SECTION: CDIN

STUDY_SECTION_NAME: Chronic Dysfunction and Integrative Neurodegeneration Study Section[CDIN]


NIH_SPENDING_CATS: Bioengineering;Cancer;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: PHILADELPHIA

ORG_NAME: RESEARCH INST OF FOX CHASE CAN CTR

PHR: Project Narrative Proteins function through their three-dimensional structures, which may be determined experimentally or through computational methods. The latter has undergone huge advances just in the last year. In this project, we will bring experimental and computed protein structures to problems in cancer biology through statistical study of protein families critical to cancer development and therapeutics and collaborative work with Fox Chase colleagues working in many fields of experimental and clinical cancer research.

PI_NAMEs: DUNBRACK, ROLAND L (contact)

PROGRAM_OFFICER_NAME: GERSHENSON, ANNE

PROJECT_TERMS: Advanced Malignant Neoplasm;anti-cancer research;Antibodies;Bioinformatics;C-terminal;Cancer Biology;Classification;Clinical;Complex;Computing Methodologies;Cryoelectron Microscopy;Crystallography;Databases;deep field survey;deep learning;design;Development;Fox Chase Cancer Center;Homo;Human;Laboratories;Malignant Neoplasms;medical schools;Methods;Molecular;Phosphotransferases;Play;programs;protein complex;Protein Dynamics;Protein Family;protein function;protein structure;protein structure prediction;Proteins;Research;Role;Sequence Alignment;simulation;Spectrum Analysis;Statistical Data Interpretation;Statistical Study;structural biology;Structure;T-Cell Receptor;Tail;Techniques;Technology;Therapeutic;Therapeutic Uses;three dimensional structure;Universities;unsupervised learning;Variant;Work

PROJECT_TITLE: Structural Bioinformatics of Proteins and Protein Complexes and Applications to Cancer Biology

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Neurosciences;Pediatric

ORG_CITY: CAMBRIDGE

ORG_NAME: HARVARD UNIVERSITY

PHR: NARRATIVE Arithmetic and reading are the most fundamental skills acquired during elementary school, but despite their significance for academic achievement, employment prospects, and mental health, many children and adults in developed societies exhibit non-proficient reading and arithmetical abilities. A strong neurocognitive and genetic link between reading and arithmetic ability as well as high co-occurrence rates of reading and arithmetical learning difficulties have been shown, and this application proposes a longitudinal investigation that aims to (a) compare typical and atypical developmental trajectories of reading and arithmetic from kindergarten to third grade, (b) characterize similarities, differences, and classification power of neural and cognitive measures to profile the shared mechanisms underlying arithmetic and reading, and (c) determine a set of predictors in kindergarten of arithmetic and reading outcome after four years of formal instruction. Understanding the shared and distinct underlying neural and cognitive mechanisms between typical and atypical arithmetic and reading skills will be of great significance for the development of early screening, diagnostic, and intervention tools.

PI_NAMEs: GAAB, NADINE  (contact)

PROGRAM_OFFICER_NAME: MILLER, BRETT

PROJECT_TERMS: Academic achievement;Adult;Affect;Age;Arithmetic;behavior measurement;Behavioral;Brain;Brain region;Child;Classification;Cognitive;cognitive skill;Development;Diagnostic;Early Intervention;early screening;Education;elementary school;Emotional;Employment;Exclusion;executive function;Exhibits;Family history of;field study;first grade;functional hypothalamic amenorrhea;Genetic;Growth;Individual;Instruction;Intervention;Investigation;kindergarten;Knowledge;Language;Learning Difficulty;Learning Disabilities;Linguistics;Link;literacy;Longitudinal Studies;Maps;Measurement;Measures;Mental Health;Modeling;Modernization;neural;neural correlate;Neurobiology;Neurocognitive;neuroimaging;neuromechanism;Outcome;Parietal;predictive modeling;Preventive;Probability;Process;Psychometrics;Reading;reading ability;reading difficulties;remediation;Research Design;Risk;second grade;Short-Term Memory;skill acquisition;skills;social;Societies;Students;Subgroup;third grade;Time;tool;Writing

PROJECT_TITLE: Examining distinct and shared mechanisms underlying arithmetic and reading development through behavioral and neural measures: alongitudinal investigation


ORG_CITY: Chicago

ORG_NAME: NORTHWESTERN UNIVERSITY

PHR: Project Narrative This proposal seeks funding for the seventh cycle of our training program in Pathophysiology and Rehabilitation of Neural Dysfunction (PRND). The specific objectives are to train prospective researchers from engineering and the basic sciences who understand the spectrum of problems confronting people with neurologic disabilities, and who possess the clinical, scientific, and quantitative skills to alleviate the burden on this growing population.

PI_NAMEs: HARGROVE, LEVI JOHN (contact)

PROGRAM_OFFICER_NAME: NITKIN, RALPH M

PROJECT_TERMS: Functional disorder;Neuronal Dysfunction;Rehabilitation therapy


ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: Project Narrative This proposal aims to leverage the efficient zebrafish model to understand why only some truncational mutations in TTN lead to cardiomyopathy, and which signaling pathways are involved in its pathogenesis that can be manipulated for therapeutic benefits.

PI_NAMEs: XU, XIAOLEI  (contact)

PROGRAM_OFFICER_NAME: EVANS, FRANK

PROJECT_TERMS: Accounting;Address;Adult;Affect;Alleles;Animal Model;Autophagocytosis;Biological Assay;C-terminal;candidate identification;Cardiomyopathies;chemical genetics;Collection;Data;Diagnosis;differential expression;Dilated Cardiomyopathy;Disease;Embryo;Foundations;FRAP1 gene;Genes;Genetic;Genetic Screening;Genetic study;genetic variant;genome editing;Genotype;Heart;Heart Diseases;Heterogeneity;Heterozygote;in vivo;induced pluripotent stem cell;inherited cardiomyopathy;inhibition of autophagy;insight;knock-down;Lead;Lesion;Link;MAP Kinase Gene;Maps;Mediating;Modeling;Molecular;mouse model;mTOR inhibition;mutant;Mutation;N-terminal;novel;Pathogenesis;Pathogenicity;Pathologic;Pathway interactions;Patients;Peptides;Persons;Phenotype;Population;prevent;Proteins;Quality Control;Rattus;Research;Role;Sarcomeres;scale up;Signal Pathway;Signal Transduction;Solid;Splice-Site Mutation;Technology;Testing;Therapeutic;therapeutic development;Therapeutic Effect;therapeutically effective;titin 1;tool;Variant;Zebrafish

PROJECT_TITLE: Genetic Studies of Sarcomere-based Cardiac Diseases

STUDY_SECTION: MPPA

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology A Study Section [MPPA]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Genetics;Neurosciences;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: BIRMINGHAM

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

PHR: PROJECT NARRATIVE Glioblastoma multiforme (GBM) is the most common and lethal brain malignancy with no targeted therapy available. This project is to achieve a comprehensive understanding of SON functions in altering the RNA splicing program in GBM and to evaluate the therapeutic potential of targeting SON in vivo. The knowledge generated from this study will advance our understanding of the functional significance of RNA splicing in GBM and will lead to the development of a novel strategy for targeted therapy.

PI_NAMEs: AHN, ERIN EUN-YOUNG (contact)

PROGRAM_OFFICER_NAME: MAAS, STEFAN

PROJECT_TERMS: Affect;Alternative Splicing;Apical;Automobile Driving;Biological;Biology;Brain;Cell Cycle Progression;cell growth;Cells;chemotherapy;clinically significant;cofactor;Complex;Data;Data Analyses;Development;Diagnosis;Differentiation and Growth;DNA Binding;DNA Repair;Epidermal Growth Factor Receptor;Excision;Exons;Future;Gene Abnormality;Gene Expression;Genes;genome-wide;genome-wide analysis;Glioblastoma;Glioma;Hematologic Neoplasms;Heterogeneous-Nuclear Ribonucleoproteins;Impairment;In Vitro;in vivo;inhibitor;Introns;knock-down;Knowledge;Malignant Neoplasms;Mediating;Meditation;Messenger RNA;Molecular;Mutation;Nerve Block;nerve stem cell;neural;new therapeutic target;non-genetic;novel strategies;novel therapeutic intervention;Nuclear;Oncogenic;patient derived xenograft model;Patients;PDGFRA gene;Polypyrimidine Tract-Binding Protein;Positioning Attribute;Process;Production;programs;Proteins;Radiation therapy;recruit;Recurrence;Regulation;Research;RNA;RNA Binding;RNA Splicing;Role;Sampling;Site;Solid Neoplasm;Specific qualifier value;Splice-Site Mutation;Spliceosomes;stem cell genes;stem cells;targeted treatment;temozolomide;Testing;Therapeutic;TP53 gene;Transcript;tumor;Up-Regulation;Xenograft Model

PROJECT_TITLE: SON-mediated RNA splicing in glioblastoma

STUDY_SECTION: CAMP

STUDY_SECTION_NAME: Cancer Molecular Pathobiology Study Section[CAMP]


ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: The proposed research provides fundamental knowledge about how greenhouse gases are regulated by bacterial metalloenzymes and advances bio-inspired synthetic methods useful in constructing pharmaceuticals and other complex organic molecules.

PI_NAMEs: MANKAD, NEAL P (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TERMS: Active Sites;Area;Atmosphere;Biology;Carbon Dioxide;Carbon monoxide dehydrogenase;Catalysis;catalyst;chemical synthesis;Chemicals;Complex;design;Drug Industry;Electrons;Geometry;greenhouse gases;Health;Human;improved;Knowledge;Laboratories;Maps;metallicity;metalloenzyme;Metals;Methods;Mononuclear;Nitrous Oxide;nitrous oxide reductase;Organic Chemistry;Pattern;Pharmacologic Substance;Planet Earth;Productivity;Protons;Reaction;Regulation;Research;small molecule;Study models;System;Technology;tool;Work

PROJECT_TITLE: Multimetallic Catalysis in Biology and Synthesis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-P(55)R]


ORG_CITY: HADLEY

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF MASSACHUSETTS AMHERST

PHR: PROJECT NARRATIVE Human cells use actin polymer networks for health-critical activities including the migration of white blood cells to sites of infection, cancer metastasis, as well as ingesting molecules, and moving objects around inside the cell. This project seeks to understand how cells control distinct actin-mediated activities and how cells organize changes in actin networks during development. Determining the basic mechanisms that allow cells to control actin functions can help in the development of synthetic cells for targeted drug delivery as well as in the identification of new therapeutic targets for immune system disorders and cancers.

PI_NAMEs: FRITZ-LAYLIN, LILLIAN KATHLEEN (contact)

PROJECT_TERMS: Actins;cell motility;Cell Polarity;cell type;Cells;Control Animal;Cytoskeleton;Development;Drug Delivery Systems;Drug Targeting;Endocytosis;Evolution;falls;Fission Yeast;fungus;Gene Expression;Health;Human;Immune System Diseases;Infection;Ingestion;Leukocytes;Malignant Neoplasms;Mammalian Cell;Mediating;Methods;migration;Modeling;Molecular;multitask;Neoplasm Metastasis;new therapeutic target;Organizational Change;polymerization;Polymers;Positioning Attribute;Proteins;Regulation;Saccharomycetales;Site;Specific qualifier value;System;Time;trafficking;Work;Yeasts

PROJECT_TITLE: Chytrid fungi and the functional specification of actin networks


NIH_SPENDING_CATS: Clinical Research;Genetics;Hematology;Infectious Diseases;Malaria;Pediatric;Rare Diseases;Sickle Cell Disease;Vector-Borne Diseases

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: PROJECT NARRATIVE Despite significant improvements in the control and treatment of malaria infections in many parts of Africa, children with sickle cell disease (SCD) remain particularly vulnerable to fatal infections, a phenomenon that remains poorly understood. Fetal hemoglobin (HbF) and other red blood cell (RBC) factors influence SCD pathology and, by their effects on sickle hemoglobin (HbS) polymerization, may also affect malaria parasitemia and virulence. This research proposal aims to understand P. falciparum growth in SCD, including the SCD RBC host factors that either protect against or worsen severe malaria infection, and identify potential therapeutic targets for individuals with co-morbid SCD.

PI_NAMEs: ARCHER, NATASHA MARIE BERNADETTE (contact)

PROGRAM_OFFICER_NAME: HATTANGADI, SHILPA MANOHAR

PROJECT_TERMS: Advisory Committees;Affect;Africa;alpha-Thalassemia;Area;Award;Binding;Biological Assay;Boston;career;Cell Cycle;Cell Cycle Stage;cell type;Cells;Cellular Assay;Cellular biology;Cessation of life;Child;clinically relevant;Communities;comorbidity;Coupled;Data;Digestion;Disease;Disease Outcome;DNA biosynthesis;Education;Epidemiology;Erythrocytes;experience;Falciparum Malaria;Fetal Hemoglobin;fetal infection;Genes;Genetic;Genetic Polymorphism;genome sequencing;Genotype;Goals;Growth;Hemoglobin;hemoglobin AA;Hemoglobin C;Hemoglobin F Disease;hemoglobin polymer;Hemoglobin SC Disease;Hemoglobinopathies;Heterozygote;Hypoxia;improved;In Vitro;in vitro Model;in vivo Model;Individual;Infection;Inherited;Institution;Integration Host Factors;International;Leadership;Malaria;malaria infection;Maps;mathematical model;Mathematics;Mediating;Mentors;Modeling;Molecular;Morbidity - disease rate;mortality;Mutate;Mutation;Newborn Infant;novel;Outcome;Oxygen;parasite genome;Parasitemia;Parasites;Pathology;Patients;Pediatric Hematologist;Pediatric Hematology;Pediatric Hospitals;Phenotype;Physicians;Plasmodium falciparum;Ploidies;Point Mutation;polymerization;Polymers;Population;Positioning Attribute;premature;programs;Proliferating;Public Health Schools;Research;Research Personnel;Research Proposals;Resistance;resistant Plasmodium falciparum;reverse genetics;Role;Scientist;Severities;Shapes;Sickle Cell Anemia;Sickle Cell Trait;Sickle Hemoglobin;sickling;skills;Staging;Structure;Subgroup;Testing;Thalassemia;Therapeutic;therapeutic target;Training;Transgenic Organisms;Umbilical Cord Blood;Virulence;Virulent;Work

PROJECT_TITLE: Red blood cell modifiers for Plasmodium falciparum growth in sickle cell disease erythrocytes

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Data Science;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Substance Misuse

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE  County public health officials have expressed the need to identify local, actionable opiate overdose trends and inform plans to reduce opiate misuse and mortality in their counties. The proposed research will examine patterns in opioid overdose hotspots; identify opioid treatment deserts; correlate outcomes with sociodemographic variables; and describe local factors contributing to opioid disparities at the sub-county level. Designing these analyses for a hyperlocal examination of opioid use disorder will inform policy, spur future innovation, and direct targeted community health interventions to address this urgent public health crisis.

PI_NAMEs: JAROS, SAMUEL  (contact)

PROGRAM_OFFICER_NAME: PARKER, ERIN MARGARET

PROJECT_TERMS: Address;Age;American;Bayesian Modeling;Behavioral;Big Data;Calibration;California;career;Charities;citizen science;Clinical;Cloud Computing;Collaborations;Color;Communities;Community Health;Computing Methodologies;County;COVID-19;dashboard;Data;data ecosystem;Data Science;Data Sources;design;Development;Discipline;Disease;Disparity;Economic Factors;Economics;Emergency medical service;Environmental Risk Factor;Epidemiology;epidemiology study;ethnic minority population;Ethnic Origin;experience;Face;faculty mentor;Fellowship;Future;Gender;Grant;Health;health care availability;health data;health determinants;HIV Infections;Homelessness;Hospitalization;Housing;Income;Infrastructure;Ingestion;innovation;insight;Intervention;Interview;Investments;Linear Regressions;Link;Location;Maps;Mentors;Mentorship;Methods;Modeling;Not Hispanic or Latino;Opiate Addiction;Opioid;opioid epidemic;opioid misuse;opioid mortality;opioid overdose;opioid use;opioid use disorder;opioid user;Outcome;Overdose;Patients;Pattern;Persons;Policies;Policy Maker;Population;Population Analysis;population health;Postdoctoral Fellow;Poverty;predictive modeling;programs;Psychiatry;Psychologist;Public Health;public health research;Qualitative Methods;Qualitative Research;Race;racial difference;racial minority population;Reproducibility;Research;Research Methodology;Research Personnel;Resource Allocation;Resources;response;Role;rural area;Rural Community;rural dwellers;rural setting;Science;skills;social;social epidemiology;social factors;Social Work;sociodemographic variables;statistics;stem;Structure;suburban communities;System;Time;Time trend;Tobacco use;Training;Transportation;Travel;treatment center;trend;Uncertainty;United States;Universities;urban area;Urbanicity;Visualization;Vulnerable Populations;web platform;Work

PROJECT_TITLE: Examining patterns of opioid overdose hotspots and opioid treatment deserts in California

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F18-L(20)L]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Contraception/Reproduction;Genetics;Infectious Diseases;Infertility;Sexually Transmitted Infections;Sleep Research;Women's Health Research

ORG_CITY: ATLANTA

ORG_NAME: MOREHOUSE SCHOOL OF MEDICINE

PHR: Complications arising from Chlamydia infection are of public health importance. This study involves understanding the novel mechanisms associated with circadian rhythms and Chlamydia- induced pathogenesis that may lead to tubal factor infertility. This proposal is relevant to NIH's mission, it will identify new disease biomarkers, pathways and elucidate the molecular mechanisms underpinning pathogenesis caused by chlamydia infection, thus impacting women's reproductive health.

PI_NAMEs: OMOSUN, YUSUF OSEOBHUNU (contact)

PROGRAM_OFFICER_NAME: VINCENT, LEAH REBECCA

PROJECT_TERMS: Affect;African Trypanosomiasis;ARNTL gene;Bacterial Sexually Transmitted Diseases;Biological Markers;Cells;Chlamydia;Chlamydia Infections;Chlamydia muridarum;Chlamydia trachomatis;circadian;Circadian Dysregulation;circadian pacemaker;Circadian Rhythms;Contracts;cryptochrome;Darkness;Development;differential expression;Disease;Disease Outcome;endometriosis;experimental study;Feedback;Fertility;Fibrosis;Genes;Genetic;Genetic Transcription;Goals;Hour;Human Herpesvirus 2;Infection;Infertility;Inflammation;Inflammatory Response;Influenza;innovation;insight;Jet Lag Syndrome;Knockout Mice;Knowledge;Malaria;Mediating;MicroRNAs;Mission;Modeling;Molecular;Mus;nano-string;novel;Ontology;Outcome;pathogen;Pathogenesis;Pathogenicity;Pathologic;Pathology;Pathway interactions;Pelvic Inflammatory Disease;Periodicity;Physiological;Physiology;Predisposition;Principal Investigator;programs;Proteins;Public Health;Reporting;Repression;reproductive tract;Research;response;Rest;Role;Salmonella typhimurium;Salpingitis;Severities;Sleep Disorders;Symptoms;Technology;Testing;Time;transcription factor;transcriptomics;tubal infertility;United States;United States National Institutes of Health;Variant;Woman;women's reproductive health;Work

PROJECT_TITLE: Determining the role of circadian rhythms in Chlamydia associated tubal infertility


ORG_DEPT: NEUROSURGERY

PHR: PROJECT NARRATIVE: We seamlessly extract both linguistic and non-linguistic information when listening to someone speaking. This proposal aims to characterize neural responses in human auditory cortex to voice and to describe the connectivity of these regions to higher order brain areas. Knowing how voice is processed in the brain is fundamental to understanding social communication, voice recognition, and development of novel therapies for communication disorders.

PI_NAMEs: HECT, JASMINE LEAH (contact)

PROGRAM_OFFICER_NAME: SCHURMAN, JACLYN REBECCA

PROJECT_TERMS: Acoustics;Anatomy;Anterior;Area;Auditory area;auditory stimulus;blood oxygenation level dependent response;Brain;Characteristics;Childhood;Classification;Clinical;Code;Communication;Communication impairment;Complex;Cues;Data;Dedications;Development;Diffusion Magnetic Resonance Imaging;Dimensions;Distant;Electroencephalography;Electrophysiology (science);Emotions;Engineering;Epilepsy;Evaluation;Exhibits;Family;frontal lobe;Functional Magnetic Resonance Imaging;Gender;Human;Inferior frontal gyrus;interest;Linguistics;Measures;Mentors;Modeling;Monitor;multidisciplinary;multimodal data;multimodal neuroimaging;multimodality;neural;neural network;neuroimaging;Neurons;neurophysiology;neurosurgery;Noise;nonhuman primate;novel;novel therapeutics;Operative Surgical Procedures;Participant;Pathway interactions;Patients;Pattern;Perception;Physiological;Population;Precentral gyrus;Primates;Process;Production;Property;Psycholinguistics;Publishing;recruit;Research;Research Training;response;Scientist;Sensory Disorders;social communication;sound;Speech Perception;Stimulus;structural imaging;Structure of superior temporal sulcus;Superior temporal gyrus;support network;Temporal Lobe;Testing;theories;tractography;Training;training opportunity;verbal;vocalization;Voice;voice recognition;white matter;Work

PROJECT_TITLE: Intracranial Electrophysiology & Anatomical Connectivity of Voice-Selective Auditory Cortex


NIH_SPENDING_CATS: Emerging Infectious Diseases;Genetics;Infectious Diseases;Kidney Disease;Urologic Diseases

PHR: Project Narrative BK virus (BKV) causes serious diseases in transplant recipients and other patients with compromised immune systems. Successful infection requires that BKV redirects specific cellular systems towards viral replication, while simultaneously evades or neutralizes antiviral defenses. This proposal aims to identify cellular proteins and signaling pathways that differentially promote or restrict BKV infection in clinically relevant cell types.

PI_NAMEs: PIPAS, JAMES M (contact)

PROGRAM_OFFICER_NAME: ALARCON, RODOLFO M

PROJECT_TERMS: Anti-viral Agents;Anti-viral Response;Antigens;Biology;BK Virus;Candidate Disease Gene;cdc Genes;Cell Death;Cell Line;Cell Nucleus;Cell Physiology;cell type;Cells;Chemistry;chronic infection;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Collection;Complex;Coupled;Critical Pathways;Cystitis;Data;design;Disease;DNA;Epithelial Cells;Equilibrium;established cell line;Excretory function;experience;experimental study;Family;Gene Expression;Genes;Genetic Transcription;Hemorrhage;Human;Immune;Immune system;Immunocompromised Host;In Vitro;in vivo;Individual;Infection;Inflammatory Response;Innate Immune Response;Innate Immune System;insight;Interferon Activation;Interferon Type I;Interferons;IRF3 gene;Kidney;kidney cell;Kidney Diseases;Knock-out;Knowledge;Label;Laboratories;Literature;Maintenance;Maps;Mass Spectrum Analysis;Mediating;Messenger RNA;Metabolic;Modeling;Molecular;monolayer;mutant;Natural Immunity;Nuclear;Outcome;overexpression;particle;Pathway interactions;Patients;Phosphorylation;Play;Polyomavirus;Population;Positioning Attribute;Production;Productivity;Proteins;Proximal Kidney Tubules;Reporting;Repression;Research;response;Role;S phase;sensor;Signal Pathway;Signal Transduction;Simian virus 40;Site;STAT1 gene;STING1 gene;System;Tissues;tool;transcription factor;transcriptome sequencing;transcriptomic profiling;transcriptomics;Transplant Recipients;Tropism;Tumor Antigens;Up-Regulation;Urinary system;Urinary tract;Urine;Vascular Endothelial Cell;Viral;viral DNA;Viral Pathogenesis;Viral Physiology;Viral Proteins;Virion;Virus;Virus Diseases;Virus Replication;Virus-Cell Membrane Interaction;Work

PROJECT_TITLE: Manipulation of innate immunity by Polyomavirus T antigens

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDM-Y(02)M]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Contraception/Reproduction;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Infant Mortality;Infectious Diseases;Influenza;Lung;Maternal Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pneumonia and Influenza;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Vaccine Related;Women's Health Research

ORG_CITY: SEATTLE

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE Acute respiratory infections are among the leading causes of neonatal mortality worldwide with low birth weight infants particularly susceptible and at risk for perinatal mortality. Maternal immunizations are increasingly being used as an infection prevention strategy to protect neonates and infants from respiratory pathogens, yet maternal immunization and transplacental antibody transfer are incompletely understood in pregnancies complicated by prematurity or placental insufficiency leading to small for gestational age infants. This proposal aims to quantify and characterize transplacental antibody transfer and maternal and neonatal immune interactions in these high-risk pregnancies in order to optimize neonatal immunity against respiratory pathogens such as influenza and SARS-CoV-2 in at-risk low birth weight infants.

PI_NAMEs: KACHIKIS, ALISA  (contact)

PROGRAM_OFFICER_NAME: BOZICK, BROOKE ALLISON

PROJECT_TERMS: 2019-nCoV;Acute respiratory infection;Affect;Antibodies;antibody test;Antibody titer measurement;antibody transfer;Antigens;biophysical properties;Biophysics;burden of illness;career;Chorionic villi;Clinical;Clinical Trials;cohort;Cohort Studies;Communicable Diseases;Computational Biology;Computer Analysis;COVID-19 vaccine;Dedications;Development;Discipline of obstetrics;Effector Cell;Enzyme-Linked Immunosorbent Assay;Fc Receptor;fetal;Fetus;Gestational Age;global health;Goals;high risk;high risk population;High-Risk Pregnancy;Immune;immune function;Immunity;Immunization Programs;Immunoglobulin G;Immunohistochemistry;Immunology;Impairment;improved;Incidence;Infant;Infection;Infection prevention;Inflammatory;Influenza;influenza virus vaccine;innovation;insight;Knowledge;Low Birth Weight Infant;Lytic;Maternal antibody;maternal vaccination;Mentorship;Methods;Modeling;Mothers;Nature;Neonatal;neonatal Fc receptor;neonatal immune system;neonatal immunity;neonatal infection;Neonatal Mortality;neonate;novel;novel strategies;novel vaccines;pathogen;Pathology;Perinatal mortality demographics;Physicians;Placenta;Placental Insufficiency;placental morphology;placental transfer;Plasma;Population;Predisposition;Pregnancy;Pregnancy Complications;Pregnant Women;premature;Prevention strategy;Process;programs;prospective;Qualifying;receptor expression;Research;Research Personnel;Research Training;Resource-limited setting;respiratory;Respiratory Disease;respiratory pathogen;Respiratory Tract Infections;respiratory virus;Risk;Sampling;Scientist;Serology;Shapes;skills;Small for Gestational Age Infant;Statistical Data Interpretation;statistics;success;Syncytiotrophoblast;System;Testing;Training;Training Programs;translational research program;Umbilical Cord Blood;Vaccinated;Vaccination;vaccination strategy;vaccine delivery;Vaccines;vaccinology;virology;Woman

PROJECT_TITLE: Protection of at-risk low birth weight infants against influenza via maternal antibody

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases Advisory Committee[MID]


NIH_SPENDING_CATS: Bioengineering;Cancer;Genetics

ORG_CITY: SALT LAKE CITY

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE The accurate segregation of chromosomes during cell division is fundamental to cellular and organismal fitness, illustrated by the findings that errors in this process occur in nearly all tumor cells and are the leading cause of miscarriages and congenital birth defects in humans. We propose to investigate two critical questions about this process, how are chromosomes correctly attached to the segregation machinery, and once they are, how do they maintain these attachments? Since defects in these processes have been implicated in human disease, this work will elucidate the molecular mechanisms that mediate proper attachments and will help determine to what extent these defects lead to human diseases such as cancer.

PI_NAMEs: MILLER, MATTHEW P (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TERMS: Address;Affect;Binding;Binding Sites;biochemical tools;Biological;Biological Assay;biophysical tools;Cell division;Cells;Chromosome Segregation;Chromosomes;Congenital Abnormality;Defect;Ensure;fitness;Genetic;Human;human disease;In Vitro;innovation;insight;Kinetochores;Knowledge;Lead;Malignant Neoplasms;Measures;mechanical force;Mechanics;mechanotransduction;Mediating;Microtubules;Molecular;Monitor;Mutation;neoplastic cell;novel;Pathway interactions;Process;protein complex;Proteins;reconstitution;segregation;Self Correction;Side;Spontaneous abortion;Structure;Time;tool;transmission process;Tubulin;Work

PROJECT_TITLE: Mechanical activities ensuring accurate chromosome segregation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-H(55)R]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Disability Research;Pediatric;Social Determinants of Health

PHR: MARC NARRATIVE The mission of the UCSD-MARC program is to unlock the scientific potential of undergraduate students from ethnic groups underrepresented in science, from socio-economic disadvantaged backgrounds, and students with disabilities. This mission is accomplished by motivating, mentoring, and training undergraduate students in experimental planning, time management, data collection, interpretation, reproducibility, presentations, and ethics, with the final goal of enrolling in and completing a Ph.D. program and becoming conscientious leaders.

PI_NAMEs: DE MAIO, ANTONIO  (contact);LAWSON, MARK ANDREW

PROGRAM_OFFICER_NAME: STOKES, KALYNDA K

PROJECT_TERMS: Address;African;American;California;career;career development;college;Communities;Cultural Backgrounds;Data Collection;disability;disabled students;Disparity;Doctor of Philosophy;Economically Deprived Population;Education;Enrollment;Environment;Ethics;Ethnic Origin;Ethnic Population;experience;Funding;Goals;higher education;interest;International;K-Series Research Career Programs;Latino;leadership development;Life Experience;Mentors;Mentorship;Mission;Persons;Phase;prevent;Productivity;Program Development;programs;Records;Reproducibility;Research;Research Activity;Research Personnel;Research Project Grants;Resources;Science;Scientist;Self Efficacy;skills;social;socioeconomic disadvantage;socioeconomics;student training;Students;success;Supervision;Talents;Technology;Time Management;Training;undergraduate student;Underrepresented Students;underserved community;Universities;university student

PROJECT_TITLE: MARC at University of California, San Diego

STUDY_SECTION_NAME: Training and Workforce Development Study Section - C[TWD-C]


NIH_SPENDING_CATS: Cancer;Childhood Leukemia;Genetics;Hematology;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: CLEVELAND

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

PHR: Project Narrative The proposed research aims to uncover the underlying mechanisms whereby heat shock transcription factor 1 is specifically required for the self-renewal of acute myeloid leukemia stem cells. The results of our proposal will have a profound clinical relevance for treating and monitoring acute myeloid leukemia.

PI_NAMEs: ZHAO, CHEN  (contact)

PROGRAM_OFFICER_NAME: KLAUZINSKA, MALGORZATA

PROJECT_TERMS: Ablation;Acute Myelocytic Leukemia;acute myeloid leukemia cell;Affect;amino acid metabolism;Apoptosis;Biology;Biopsy Specimen;Bone marrow biopsy;Bone Marrow Cells;cancer cell;CD34 gene;cell injury;chemotherapy;ChIP-seq;Chromatin;Clinical Markers;clinically relevant;Cytoprotection;Data;Defect;Development;DNA metabolism;Dysmyelopoietic Syndromes;Energy Metabolism;Epigenetic Process;Epithelial Cells;experience;Feedback;Frequencies;Gene Expression;Genes;genetic manipulation;Genetic Transcription;glucose metabolism;Growth;Heat shock proteins;heat shock transcription factor;Heat-Shock Transcription Factor 2;Hematopoiesis;Hematopoietic stem cells;hepatocyte nuclear factor;Homeostasis;Human;Impairment;improved;intestinal epithelium;Knowledge;leukemia;Leukemic Cell;leukemic stem cell;Liver;Lymphoblastic Leukemia;Maintenance;Malignant - descriptor;Minority;misfolded protein;Mitochondria;MLL-AF9;Modeling;Molecular;Monitor;Mus;Mutate;Myelodysplastic/Myeloproliferative Disease;Myeloproliferative disease;Oncogenes;Outcome;overexpression;Oxidative Phosphorylation;Pathway interactions;Patients;Play;Proliferating;protein metabolism;Proteins;proteotoxicity;reconstitution;Relapse;Research;Role;self-renewal;Signal Transduction;Signaling Molecule;small molecule;small molecule inhibitor;Solid Neoplasm;stem cell function;stem cell proliferation;stem cell self renewal;stemness;Stress;success;Testing;therapeutic target;transcription factor;transcriptomics;treatment effect;treatment response;tumorigenesis

PROJECT_TITLE: Heat Shock Transcription Factor 1 Specifically Regulates AML Stem Cell Self-Renewal

STUDY_SECTION: MCH

STUDY_SECTION_NAME: Molecular and Cellular Hematology Study Section[MCH]


NIH_SPENDING_CATS: Genetics;Infectious Diseases;Networking and Information Technology R&D (NITRD)

ORG_CITY: CHICAGO

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF CHICAGO

PHR: PROJECT NARRATIVE Geography plays an important role in structuring genetic variation in numerous species that are relevant to human health. This project will develop novel theoretical models and computational tools to empower researchers to analyze and interpret the geographic distribution of genetic variation, with an emphasis on understanding neutral, deleterious, and adaptive genetic variants.

PI_NAMEs: NOVEMBRE, JOHN  (contact)

PROGRAM_OFFICER_NAME: WANG, PEGGY

PROJECT_TERMS: Alleles;Area;Communicable Diseases;computerized tools;Data;Detection;empowerment;Gene Frequency;Genetic;Genetic Structures;genetic variant;Genetic Variation;genome wide association study;Geographic Distribution;Geography;Graph;Health;Human;Human Genetics;Individual;loss of function;Mediating;Methods;migration;model building;novel;pathogen;Pattern;Play;Population;Population Genetics;Process;Reproduction;Research;Research Personnel;Resources;Role;Sampling;Series;Structure;Theoretical model;theories;trait;Variant;Visualization

PROJECT_TITLE: Theory, Methods, and Resources for Understanding and Leveraging Spatial Variation in Population Genetic Data

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


ADMINISTERING_IC: LM

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Clinical Research;Data Science;Networking and Information Technology R&D (NITRD);Pediatric

ORG_CITY: Washington

ORG_NAME: AMERICAN MEDICAL INFORMATICS ASSN

ORG_STATE: DC

PHR: Project Narrative The future of health care in the United States depends on a robust and diverse workforce of biomedical informatics and data science professionals. This project will continue to support and enhance a mini- symposium for high school scholars and thus inspire future generations to consider STEM-C careers, especially in health care and biomedicine.

PI_NAMEs: SARKAR, INDRA N (contact);UNERTL, KIM M

PROGRAM_OFFICER_NAME: REDDY, GOUTHAM

PROJECT_TERMS: Awareness;biomedical informatics;career;Career Choice;Communities;Computational Science;Country;Data Science;Data Scientist;Development;Discipline;Diverse Workforce;Education;Educational Curriculum;Ensure;ethnic minority;Event;experience;Exposure to;Face;Family;Funding;Future;Future Generations;Generations;Goals;graduate student;Grant;Growth;health data;Healthcare;Hearing;high school;High School Faculty;high school program;High School Student;improved;Individual;Informatics;Information Sciences;Institution;interest;Internships;Knowledge;Learning;Medical Informatics;Medical Students;Mentors;Oral;outreach;Participant;Pathway interactions;peer;posters;programs;racial minority;Research;Research Project Grants;Scholars Program;science teacher;Science, Technology, Engineering and Mathematics;Students;success;summer internship;symposium;Talents;teacher;Training;Training Programs;undergraduate student;United States;Woman

PROJECT_TITLE: New Paths for Biomedical Informatics: A Mini-Symposium for High School Scholars


NIH_SPENDING_CATS: Biomedical Imaging;Clinical Research;Lung;Neonatal Respiratory Distress;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Precision Medicine;Preterm, Low Birth Weight and Health of the Newborn;Rare Diseases

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: PROJECT NARRATIVE Bronchopulmonary dysplasia (BPD), or chronic lung disease of prematurity, is the most consequential complication of preterm birth and is strong predictor of childhood pulmonary and neurodevelopmental disability, particularly in infants diagnosed with grade 3 BPD (ventilator dependence at 36 weeks’ postmenstrual age), the most severe disease form. In this proposal, we outline our plan to (1) generate the first empirically defined phenotype classification system for grade 3 BPD developed using a rich array of objective and quantitative cardiopulmonary diagnostic, clinical, and biological data; and (2) define the association between phenotype subgroups and neurodevelopmental and respiratory outcomes through 2 years’ corrected age. Successful completion of this research will promote a long-overdue frameshift in neonatal medicine towards objective disease classification in BPD using evidence-based diagnostic testing and performance of first-of-their-kind phenotype-specific trials targeting more effective individualized care.

PI_NAMEs: JENSEN, ERIK ALLEN;LINGAPPAN, KRITHIKA  (contact)

PROGRAM_OFFICER_NAME: SOOD, BEENA G

PROJECT_TERMS: Affect;Age;Asthma;Biological;Bronchopulmonary Dysplasia;Bronchoscopy;Cardiac;Cardiopulmonary;Caring;Characteristics;chest computed tomography;Child;Childhood;Chronic;Chronic lung disease;Chronic Obstructive Pulmonary Disease;Classification;Classification Scheme;Clinical;Clinical Data;clinically relevant;Cluster Analysis;Cognition;cohort;Complication;cost;Counseling;Cystic Fibrosis;Data;Dependence;Development;Developmental Disabilities;Diagnosis;Diagnostic;Diagnostic Procedure;diagnostic strategy;diagnostic technologies;Diagnostic tests;Dimensions;Disease;disease classification;disease heterogeneity;Disease Outcome;disease phenotype;disorder subtype;dysbiosis;effective therapy;electric impedance;Enrollment;Esophagus;Evaluation;evidence base;extreme prematurity;Gastroesophageal reflux disease;Health;heart imaging;Heterogeneity;high risk;Hospitals;Hypoxemia;Image;Impairment;improved;improved outcome;Individual;Infant;Intervention;Lavage;Life;Lung;Lung CAT Scan;Lung Diseases;lung imaging;Masks;Measures;Mechanics;Medical Records;Medicine;microbial;Modeling;Monitor;Morbidity - disease rate;Neonatal;Neonatology;Neurodevelopmental Disability;Neurodevelopmental Impairment;novel;novel diagnostics;Outcome;Outcome Measure;outcome prediction;Oxygen saturation measurement;Pathologic;Pathology;patient subsets;Patients;Performance;personalized care;Phenotype;Pregnancy;premature;Premature Birth;Premature Infant;Prognosis;prognostic value;Prospective cohort;pulmonary arterial hypertension;Pulmonary Inflammation;Quality of life;Recurrence;Reporting;Research;Research Personnel;respiratory;risk stratification;Selection for Treatments;Severities;Standardization;Subgroup;System;targeted treatment;Testing;Therapeutic Intervention;treatment response;ventilation;Ventilator

PROJECT_TITLE: Multidimensional phenotype classification in grade 3 BPD

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Services;Hypertension;Prevention;Women's Health Research

ORG_CITY: NEW ORLEANS

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: Project Narrative This proposed research is highly relevant to public health because the discovery of an efficacious approach, and the associated underlying mechanism, to improve adherence to blood pressure-lowering medications is expected to represent an important step toward improving blood pressure control, reduce disease and disability, and improve quality of life in older adults. Thus, the proposed research, which evaluates a novel method to improve adherence and blood pressure control, aligns with top research priorities of the NHLBI and NIH Adherence Research Network that pertain to advancing knowledge that will help to reduce the burden of chronic diseases and improve life-long health and well-being. When this innovative behavioral intervention trial is complete, it is expected to provide a new and scalable evidence-based approach to reducing low medication adherence and CVD burden and to improving healthy aging among older women and men.

PI_NAMEs: KROUSEL-WOOD, MARIE  (contact)

PROGRAM_OFFICER_NAME: REDMOND, NICOLE

PROJECT_TERMS: Adherence;adherence rate;Adult;Anti-Hypertensive Agents;attentional control;Attitude;Automobile Driving;Behavior;behavior change;Behavior Therapy;Blood Pressure;blood pressure control;blood pressure medication;blood pressure reduction;Blue Cross;Blue Shield;burden of chronic illness;burden of illness;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;Categories;Cause of Death;Clinical;Clinical Trials;compliance behavior;Conscious;Data;design;disability;Disease;Drug Prescriptions;Effectiveness;efficacy evaluation;evidence base;Goals;Health;Health behavior;healthy aging;high risk;human old age (65+);Hypertension;hypertensive;Immunity;Implicit Association Test;improved;innovation;insight;Intervention;intervention program;Intervention Trial;Knowledge;Learning;Louisiana;Mediation;medication compliance;medication nonadherence;men;Methods;Modeling;National Heart, Lung, and Blood Institute;novel;novel strategies;older adult;older men;Older Population;older women;Outcome;Participant;Patient Self-Report;Personal Satisfaction;Pharmaceutical Preparations;Pilot Projects;primary outcome;Process;programs;psychologic;Psychological reinforcement;Psychotherapy;Public Health;Quality of life;Race;racial population;Randomized;randomized trial;Randomized, Controlled Trials;Research;Research Priority;Resistance;sex;sex variable;Side;Subconscious;Subgroup;telephone coaching;Testing;tool;treatment arm;treatment as usual;trial design;United States National Institutes of Health;Woman;Work

PROJECT_TITLE: Supporting Tailored Adaptive Change and Reinforcement for Medication Adherence Program (STAR-MAP): Randomized trial of a novel approach to improve adherence in older hypertensive women and men

STUDY_SECTION: BMIO

STUDY_SECTION_NAME: Behavioral Medicine, Interventions and Outcomes Study Section[BMIO]


NIH_SPENDING_CATS: Cancer

ORG_CITY: Nashville

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: Project Narrative This renewal application seeks support for the training of predoctoral students and postdoctoral fellows in biochemical, chemical, chemical-genetic, biological and structural approaches for cancer research. Integrated training in biochemistry, chemistry, structural biology, and cancer biology is critical to the molecular understanding of cancer and the development of new approaches to molecularly targeted therapeutics.

PI_NAMEs: HIEBERT, SCOTT W (contact)

PROGRAM_OFFICER_NAME: BOULANGER-ESPEUT, CORINNE A

PROJECT_TITLE: Biochemical and Chemical Training for Cancer Research

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]