ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: PROJECT NARRATIVE & PUBLIC HEALTH RELEVANCE STATEMENT A thorough characterization of a patient’s tumor upfront provides better outcomes, i.e., better insight affords higher survival rates. In contrast and almost anachronistically, PET imaging (the most sensitive and quantitative imaging method) is “monochromatic” as it can only assess one parameter at the time, lacking depth of information. However, the new paradigm of multicolor PET enables quantitative PET acquisitions of up to four different radiotracers at the same time, allowing us to visualize multiple targets with PET simultaneously, providing in depth mutiplexed information without increase in dose, time and cost as exemplified by interrogating the tumor microenvironment and immunotherapies for clinically relevant signatures.

PI_NAMEs: GRIMM, JAN  (contact);HERRAIZ, JOAQUIN LOPEZ;PONOMAREV, VLADIMIR ;UDIAS MOINELO, JOSE MANUEL

PROGRAM_OFFICER_NAME: TORNAI, MARTIN PAUL

PROJECT_TERMS: actionable mutation;Address;Advanced Malignant Neoplasm;Affect;American Society of Clinical Oncology;Animals;Antibodies;Bar Codes;Biological;Biological Assay;Biopsy;Cancer Biology;cancer imaging;Cancer Patient;cancer therapy;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Therapy;Cells;checkpoint inhibition;chimeric antigen receptor T cells;Clinical;clinical care;clinical imaging;clinically relevant;Collimator;Color;Complex;cost;Cytometry;Detection;detector;Discrimination;Dose;Evaluation;Event;FDA approved;Fibroblasts;fluorodeoxyglucose;frontier;Gamma Rays;genomic profiling;Image;Imaging Device;imaging modality;Immune;Immune system;Immunotherapy;improved;in vivo;Individual;insight;Isotopes;Lead;Light;Literature;Location;Macrophage;Malignant Neoplasms;Measures;Memorial Sloan-Kettering Cancer Center;Methods;Modality;Modernization;Molecular Medicine;Molecular Profiling;Monitor;Mutation;nanomedicine;neoplasm immunotherapy;neoplastic cell;next generation;novel;novel strategies;Oncology;optical imaging;Outcome;patient stratification;Patient-Focused Outcomes;Patients;Penetration;personalized medicine;Photons;Positron;Positron-Emission Tomography;predicting response;Prognosis;programmed cell death ligand 1;public health relevance;quantitative imaging;Radiolabeled;radiotracer;reconstruction;Resolution;response;Rest;Role;Scanning;Signal Transduction;single photon emission computed tomography;success;Survival Rate;System;T-Lymphocyte;temporal measurement;Testing;Therapeutic;Time;tool;Tracer;treatment response;tumor;Tumor Antigens;tumor microenvironment;tumor progression;Tumor Volume;virtual biopsy;Visualization;X-Ray Computed Tomography

PROJECT_TITLE: Multicolor PET to interrogate cancer biology

STUDY_SECTION: IPCA

STUDY_SECTION_NAME: Imaging Probes and Contrast Agents Study Section[IPCA]


ADMINISTERING_IC: DC

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

ORG_CITY: BOSTON

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: MASSACHUSETTS EYE AND EAR INFIRMARY

ORG_STATE: MA

PHR: Project Narrative Hair cells of the inner ear are responsible for detection of sound and motion. Loss of hair cells is a major cause of hearing and balance disorders. The results of hair cell loss are permanent as the adult mammalian organ of Corti - a mosaic of nonsensory supporting cells and sensory hair cells - does not have the capacity to regenerate hair cells, and currently, there is no treatment capable of arresting or reversing this hearing loss. In this proposal, we determine the role of epigenetic factors in the regeneration of hair cells. The results could lead to new treatments for these debilitating conditions.

PI_NAMEs: EDGE, ALBERT  (contact)

PROGRAM_OFFICER_NAME: FREEMAN, NANCY

PROJECT_TERMS: Acetylation;Adult;Affect;Affinity;Age;age related;ATAC-seq;Auditory Brainstem Responses;Binding;Binding Proteins;Binding Sites;Biological Assay;Cell Differentiation process;Cells;Chromatin;chromatin modification;Chromatin Remodeling Factor;Cleavage Under Targets and Release Using Nuclease;Cochlea;Complex;Confocal Microscopy;Cytomegalovirus;Data;deactivated CRISPR-Cas9;deafness;demethylation;Detection;DNA Binding;DNA Sequence;DNA-Binding Proteins;DNA-Protein Interaction;drug testing;Ear;Enhancers;epigenetic drug;Epigenetic Process;equilibration disorder;Excision;experimental study;Gene Activation;Gene Expression;Gene Silencing;Generations;Genes;genetic testing;Genetic Transcription;GFI1 gene;hair cell regeneration;Hair Cells;hearing impairment;Hearing problem;histone acetyltransferase;Histone Deacetylase;Histone Deacetylase Inhibitor;histone methylation;histone methyltransferase;Histone-Lysine N-Methyltransferase;Histones;in vivo;inhibitor;Inner Hair Cells;KDM1A gene;Laboratories;Labyrinth;Learning;LoxP-flanked allele;Mammals;Measurement;Measures;Mediating;Mediator;Methylation;Modeling;Modification;mosaic;Motion;mouse model;Mus;Natural regeneration;Nature;Newborn Infant;Noise;noise exposure;notch protein;Organ of Corti;Organoids;otoacoustic emission;overexpression;Pathway interactions;Pattern;Pharmaceutical Preparations;pharmacologic;Play;postnatal;preservation;prevent;Proliferating;promoter;protein protein interaction;Recovery of Function;recruit;response;Role;Sensory Hair;Series;Signal Pathway;single cell ATAC-seq;single-cell RNA sequencing;Site;sound;stem cells;Supporting Cell;Testing;transcription factor;Transcriptional Activation;transcriptome sequencing;transdifferentiation;Western Blotting;WNT Signaling Pathway;Work

PROJECT_TITLE: Determination of Hair Cell Fate from Postnatal Cochlear Supporting Cells

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Digestive Diseases;Genetics;Pancreatic Cancer;Rare Diseases

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: Project 2- Narrative During the previous funding cycle, our work established general principles for metabolic reprogramming in PDAC, revealing therapeutic insights that show benefit in the clinic and dramatic effects in preclinical models. In this next cycle, we will address the role of mitochondria and various concurrent gene mutations in influencing cancer cell metabolism and its interplay with the tumor microenvironment. Understanding these key roles will enable us to most effectively exploit metabolic vulnerabilities of PDAC and lead to effective therapeutic development for patients.

PI_NAMEs: EL-BARDEESY, NABEEL  (contact)

PROJECT_TERMS: Acute;Address;Alanine;Amino Acids;Antigen Presentation;Autophagocytosis;Bioenergetics;Biogenesis;Biology;cancer cell;Cancer Gene Mutation;CD8-Positive T-Lymphocytes;Cell Communication;cell stroma;Citric Acid Cycle;Clinic;Coupled;CRISPR screen;Data;Dependence;Exhibits;fatty acid oxidation;Fibroblasts;Fostering;Funding;Gene Mutation;Genetic;genetic variant;Genetically Engineered Mouse;Genotype;Glucose;glucose metabolism;Glutamine;Glycolysis;Goals;Growth;Homeostasis;Immune;Immune Evasion;Immune response;Immune signaling;Immunosuppression;Impairment;Inflammatory;inhibition of autophagy;insight;Interferons;KRAS2 gene;Link;Lysosomes;MADH4 gene;Maintenance;Malignant Neoplasms;Mediating;MEK inhibition;Metabolic;Metabolic Pathway;metabolic profile;Metabolism;Mitochondria;Modeling;mutant;Mutation;Myelogenous;NADP;novel;Nucleotide Biosynthesis;Nutrient;Organelles;Oxidation-Reduction;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma model;paracrine;Pathway interactions;Patients;Phenotype;Play;Population;pre-clinical;Pre-Clinical Model;Process;Production;programs;Regulation;response;Role;Series;Signal Transduction;Source;Squalene;STK11 gene;synergism;System;T cell infiltration;Testing;Therapeutic;therapeutic development;therapeutically effective;TP53 gene;tumor;tumor growth;Tumor Immunity;tumor metabolism;tumor microenvironment;Tumor Suppressor Proteins;Work

PROJECT_TITLE: Project 2-Identifying and exploiting metabolic vulnerabilities in PDAC


NIH_SPENDING_CATS: Biotechnology;Cancer;Digestive Diseases;Genetics;Immunotherapy;Pancreatic Cancer;Rare Diseases

PHR: Project 3 -  Narrative    The current treatment options for pancreatic cancer are not able to significantly impact the clinical outcome of  our patients, so new strategies to unravel the biology of pancreatic cancer and identify new therapeutic modalities  are urgently needed. We discovered a new vulnerability in pancreatic cancer cells that can be exploited to control  cancer progression, consisting of a unique type I collagen variant and a?3b?1 integrin signaling axis specific to  cancer cells. This new target can be combined with therapies designed to unleash the anti- tumor immune  response and suppress the altered metabolism of cancer cells in PDAC.

PI_NAMEs: KALLURI, RAGHU  (contact)

PROJECT_TERMS: adaptive immune response;anti-PD-1;anti-tumor immune response;Antitumor Response;Binding;Biological;Biology;Bypass;cancer cell;Cancer Cell Growth;Cancer Control;carcinogenesis;CD8B1 gene;Cell Communication;Cell Survival;Cells;Clinical;Clinical Trials;Collaborations;Collagen;Collagen Receptors;Collagen Type I;Combined Modality Therapy;Coupled;CRISPR screen;Data;Deposition;design;Desmoplastic;engineered exosomes;Engineering;Epigenetic Process;epigenetic silencing;exosome;experimental study;Extracellular Matrix;extracellular vesicles;Fibroblasts;Flow Cytometry;FRAP1 gene;gain of function;Genetic;Genetically Engineered Mouse;Glycolysis;Growth;Human;Human body;Hypermethylation;Immune;immune checkpoint blockade;Immune response;Immunohistochemistry;Immunosuppression;Immunotherapy;in vivo;Innate Immune Response;insight;Integrins;Knowledge;KPC model;KRAS oncogenesis;KRAS2 gene;life span;loss of function;Maintenance;Malignant neoplasm of pancreas;Metabolic;Metabolism;Modality;multiplexed imaging;Mus;neoplastic cell;novel;novel strategies;novel therapeutics;Oncogenic;Outcome;overexpression;Oxidative Phosphorylation;pancreatic cancer cells;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;pancreatic ductal adenocarcinoma model;pancreatic stellate cell;Pathogenicity;Pathologic;Patients;Play;Production;programmed cell death protein 1;Proliferating;PTK2 gene;Regulation;Role;Signal Transduction;siRNA delivery;Small Interfering RNA;synergism;T-Lymphocyte;Testing;therapy design;therapy resistant;Tissue imaging;Toxic effect;translational potential;tumor;tumor growth;Tumor Immunity;tumor metabolism;tumor progression;Tumor Suppression;Tumor-associated macrophages;Variant

PROJECT_TITLE: Project 3-Cancer cell interaction with oncogenic type 1 collagen in PDAC


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: NEW YORK

ORG_DEPT: NEUROSCIENCES

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: Project Narrative The electrical activity of local networks of excitatory and inhibitory neurons in the brain is important for regulating many aspects of behavior, including learning and memory storage. Mutations in HCN1 ion channels, which are strongly expressed in cortical neurons in the brain, have recently been implicated in both epilepsy and schizophrenia. To provide insight into the physiological function of HCN1 and its malfunction in disease, we will examine how normal and mutated HCN1 channels regulate the cellular, synaptic and behavioral contributions of a major class of inhibitory neurons that is of known importance for normal and abnormal brain function.

PI_NAMEs: SIEGELBAUM, STEVEN A (contact)

PROGRAM_OFFICER_NAME: MATOS GALICIA, HEIDI YANICE

PROJECT_TERMS: Address;Animal Behavior;Animals;anti-epileptic agents;Apical;autism symptoms;Axon;Behavior;Behavioral;Brain;Brain Diseases;brain dysfunction;Calcium;Cations;Cells;childhood epilepsy;Clinical;clinically relevant;Code;cognitive performance;CRISPR/Cas technology;cyclic-nucleotide gated ion channels;Data;de novo mutation;Dendrites;density;Disease;Distal;Early Infantile Epileptic Encephalopathy;entorhinal cortex;Epilepsy;excitatory neuron;experimental study;Family;Functional disorder;gamma-Aminobutyric Acid;Genes;Genetic;Genetic study;genome wide association study;Goals;HCN1 channel;HCN1 gene;hippocampal pyramidal neuron;Hippocampus;Human;Human Genetics;Image;Impaired cognition;in vivo;inhibitory neuron;insight;Interneurons;Ion Channel;Ion Channel Gating;Knock-in Mouse;Knock-out;Knockout Mice;Learning;Link;Long-Term Potentiation;loss of function;Membrane;Memory;mouse model;Mus;Muscle Cells;Mutate;Mutation;neocortical;neural;neuronal cell body;Neuronal Dysfunction;Neurons;Neurophysiology - biologic function;neurotransmitter release;novel therapeutic intervention;optogenetics;Parvalbumins;patch clamp;Patients;Pattern;Performance;pharmacologic;Pharmacology Study;Physiological;presynaptic;Presynaptic Terminals;prevent;Process;Property;Prosencephalon;Protein Isoforms;Pyramidal Cells;Reporting;Role;Schizophrenia;Seizures;Short-Term Memory;Slice;spatial memory;Synapses;synaptic function;Synaptic plasticity;Synaptic Transmission;Syndrome;Testing;Time;tool;Variant;voltage

PROJECT_TITLE: Role of HCN1 Channels in the Function and Malfunction of Parvalbumin Positive Interneurons

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Pancreatic Cancer;Rare Diseases

PHR: Narrative – Core D (Administrative Core) The Administrative Core (Core D) will be responsible for the overall administration of this P01 program. It will provide clerical support, meeting organization, data management and planning/evaluation services to enable effective research into PDAC biology and genetics for the purpose of informing on clinical treatment and outcomes.

PI_NAMEs: DEPINHO, RONALD ANTHONY (contact)

PROJECT_TERMS: Accounting;Annual Reports;Biology;Cancer Center;Clinical Treatment;Collaborations;Communication;Communities;Core Facility;cost;Data;data communication;data management;data sharing;Ensure;Evaluation;experience;Feedback;Fostering;General Hospitals;Generations;Genetic;Grant;Health;Institution;Internet;Laboratories;Massachusetts;medical schools;meetings;member;Monitor;Pancreatic Ductal Adenocarcinoma;Participant;performance site;Persons;Productivity;Program Research Project Grants;programs;Publications;Reagent;Reporting;Research;research data dissemination;Research Personnel;Research Project Grants;Resource Allocation;Services;treatment and outcome;Update;web site

PROJECT_TITLE: Core D- Administrative Core


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_CITY: ITHACA

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: CORNELL UNIVERSITY

PHR: PROJECT NARRATIVE Fertility requires many levels of interaction between males and females – at the level of gametes and their fates in the reproductive tract and at neural/behavioral levels – and their ultimate success varies dramatically with the genotype of the male and female involved. This variation affects the likelihood of a particular male siring offspring with a given female, due to interactions between male and female components that impact the handling of sperm within the female, and the regulation of genes in her brain. Our proposed studies with a tractable and sensitive model system will uncover the extent and mechanisms by which genetic variation can alter reproductive outcomes, and how these can be predicted analytically for given pairs of interacting animals.

PI_NAMEs: CLARK, ANDREW G (contact);WOLFNER, MARIANA FEDERICA

PROGRAM_OFFICER_NAME: KENT, TRAVIS JOHN

PROJECT_TERMS: Affect;Alternative Splicing;Animals;Automobile Driving;Behavior;Behavioral;Biological Models;Brain;Collection;Complex;Copulation;Data;Differential Fertility;Disadvantaged;Discrimination;Drosophila genus;Ejaculation;Exons;experimental study;father role;Female;female reproductive tract;Fertility;Fertilization;fitness;follow-up;Foundations;Funding;Furuncles;Future;Gene Expression Regulation;Genes;Genetic;Genetic Determinism;Genetic Variation;Genome;genome wide association study;Genotype;Germ Cells;Human;Infertility;Internet;Link;male;Maps;Mediating;Methods;model design;Modeling;Molecular;Nature;neural;Neural Pathways;Neurons;novel;Octopamine;octopamine receptor;offspring;Outcome;outcome prediction;Partner in relationship;Pathway interactions;Perception;Phenotype;Pheromone;Play;Predictive Analytics;Process;Production;programs;promoter;Regulation;Reproduction;reproductive;reproductive fitness;reproductive outcome;reproductive success;reproductive tract;response;Role;Seminal fluid;Series;sex;Sexual Reproduction;Signal Transduction;Sorting;sperm cell;Sperm Count Procedure;Spliced Genes;Sports;Statistical Models;success;Surveys;Testing;Time;Transcript;transcriptome;Validation;Variant;Whole Organism;Work;zygote

PROJECT_TITLE: REGULATION OF GAMETE USE AND NEURAL PATHWAYS IN REPRODUCTION

STUDY_SECTION: GVE

STUDY_SECTION_NAME: Genetic Variation and Evolution Study Section[GVE]


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Digestive Diseases;Genetics;Orphan Drug;Pancreatic Cancer;Rare Diseases

PHR: Core A (Pathology Core) - Project Narrative Core A, with its deep expertise in mouse and human PDAC, will play an essential role in the pathologic analysis of experiments across all three projects of this P01. The Pathology Core will continue to collect, maintain, archive and record all human and mouse PDAC-associated biological resources and provide high dimensional analysis of the epithelium and tumor microenvironment, germane to each project’s goals.

PI_NAMEs: WANG, HUAMIN  (contact)

PROJECT_TERMS: Alleles;Archives;Autopsy;Bioinformatics;Biological;Biological Assay;Biology;cancer genomics;Cell Line;cell type;chemotherapy;Clinical;Coculture Techniques;cohort;Collaborations;Collection;Complex;Credentialing;Data;dimensional analysis;Dimensions;Engineering;Epithelium;Evaluation;experimental analysis;experimental study;Fibroblasts;Foundations;Generations;Genes;Genetic;genetic association;Genetically Engineered Mouse;genomic platform;Genotype;Goals;high dimensionality;Histologic;Histology;Histopathology;Human;human tissue;Image Analysis;Immune;Immune response;Immunocompetent;Immunofluorescence Immunologic;In Situ Hybridization;in vivo;Infrastructure;Injections;Institution;interest;Investigational Therapies;Maintenance;Malignant Neoplasms;Modeling;Molecular;Molecular Abnormality;Moon;Morphology;multidimensional data;Mus;Mutation;Neoadjuvant Therapy;Neoplasms;neoplastic;neoplastic cell;Nodal;novel;Organoids;Outcome;Pancreas;Pancreatic duct;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;pancreatic ductal adenocarcinoma model;pancreatic neoplasm;Pathologic;Pathology;patient derived xenograft model;Patients;Phenotype;Play;pre-clinical assessment;preclinical study;Publications;quantitative imaging;repository;Research;Research Personnel;Resected;Resources;Role;Sampling;Scanning;Services;Signal Pathway;single-cell RNA sequencing;Slide;stem;Stromal Cells;Stromal Neoplasm;Supervision;Technical Expertise;Technology;Therapeutic;Therapeutic Intervention;Tissue Harvesting;Tissue Microarray;Tissue Sample;Tissues;tumor;tumor microenvironment;Tumor Promotion;University of Texas M D Anderson Cancer Center;Validation;virtual;Work

PROJECT_TITLE: Core A-Pathology Core


NIH_SPENDING_CATS: Biotechnology;Cancer;Digestive Diseases;Genetics;Immunotherapy;Orphan Drug;Pancreatic Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

PHR: Core B (Modeling & Experimental Therapeutics Core) - Project Narrative. Core B will generate new mouse models relevant to human pancreatic cancer. The Core will further provide the model systems and standardized protocols to perform trials that will test new drugs alone and in combinations. This Core is critical to the translation of our scientific discoveries into improved therapies for human pancreatic cancer.

PI_NAMEs: HORNER, JAMES WESLEY (contact)

PROJECT_TERMS: Alleles;Autophagocytosis;Biological;Biological Models;Biological Process;Biology;blastocyst;Breeding;cancer cell;Cancer Model;CDKN2A gene;cell type;Cells;Characteristics;Chimera organism;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;Colorectal Cancer;Communities;Complement;Complex;cost;Dedications;Dependence;design;Disease;Disease Resistance;Dissection;embryonic stem cell;Engineering;experience;experimental study;Fibroblasts;Gene Targeting;Generations;Genes;Genetic;genetic element;genetic signature;Genetically Engineered Mouse;Genotype;Germ Lines;Goals;Harvest;Human;Image;Immune;Immunity;Immunosuppression;Immunotherapy;improved;in vivo;Injections;Institution;interest;Investigational Therapies;investigator training;Knock-in;Knock-out;KRAS2 gene;Laboratories;lens;MADH4 gene;Maintenance;Malignant neoplasm of lung;Malignant neoplasm of pancreas;Malignant Neoplasms;Metabolic;Metabolism;Modeling;Monitor;mouse model;multi-arm trial;Mus;Mutation;Neoplasm Metastasis;novel;novel therapeutics;Nutrient;Oncogenes;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma model;Pathologic;Pathway interactions;Pharmaceutical Preparations;Phenotype;Play;pre-clinical;prostate cancer model;Protocols documentation;radiation resistance;Reagent;Recording of previous events;Regimen;Role;Services;Standardization;stem;Survival Analysis;System;Technology;Testing;Tetanus Helper Peptide;Therapeutic;Therapeutic Studies;Therapeutic Trials;therapy resistant;Time;Tissues;TP53 gene;Transgenic Organisms;Translations;transmission process;tumor;Tumor Immunity;tumor metabolism;tumor microenvironment;Tumor Suppressor Genes;Tumor Suppressor Proteins;vector;virtual

PROJECT_TITLE: Core B-Modeling & Experimental Therapeutics Core


ED_INST_TYPE: SCHOOLS OF EDUCATION

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Disability Research;Hearing Loss;Pediatric

ORG_DEPT: MISCELLANEOUS

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

PHR: The majority of deaf children experience a period of limited exposure to language (spoken or signed), which has cascading effects on many aspects of cognition. The goal of the current project is to understand how children build a vocabulary in sign language, and whether and how this differs for deaf children who have limited exposure to a sign language. These data will be made publicly available to researchers and practitioners interested in sign language vocabulary development.

PI_NAMEs: CASELLI, NAOMI K. (contact)

PROGRAM_OFFICER_NAME: STORKEL, HOLLY LYNN

PROJECT_TERMS: 4 year old;Adult;Affect;Age;American Sign Language;career;Cattle;Child;Childhood;Cochlear Implants;Cognition;Communication;Comprehension;critical period;Data;Data Reporting;data repository;Databases;deaf;density;Development;early childhood;Early identification;experience;Exposure to;Goals;Hearing;Horns;imprint;infancy;Infant;innovation;interest;Intervention;Knowledge;Language;Language Delays;Language Development;language outcome;Learning;lexical;Linguistics;Motivation;National Institute on Deafness and Other Communication Disorders;native American sign language;Neighborhoods;non-Native;Outcome;Parents;Persons;phonology;Play;Poverty;Production;Recommendation;Reporting;Research Personnel;Research Project Grants;Risk;risk mitigation;School-Age Population;Shapes;Sign Language;skills;Speech Sound;Technology;Testing;theories;Time;Vocabulary;Vocabulary Test;Work

PROJECT_TITLE: Effects of input quality on ASL vocabulary acquisition in deaf children

STUDY_SECTION: LCOM

STUDY_SECTION_NAME: Language and Communication Study Section[LCOM]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: FARMINGTON

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT

ORG_STATE: CT

PHR: Project Narrative: Alternative 3' UTR usage and alternative splicing occurs for the vast majority of genes in metazoan animals, including humans. The proposed research program will investigate how these two events in RNA biogenesis are coordinated to generate mRNA transcripts with specific combinations of protein-coding exons and 3' UTR sequences. !

PI_NAMEs: MIURA, PEDRO  (contact)

PROGRAM_OFFICER_NAME: CZAPLINSKI, KEVIN

PROJECT_TERMS: 3' Untranslated Regions;5' Untranslated Regions;Affect;Affinity Chromatography;Alternative Splicing;Animals;Biogenesis;Cell Proliferation;cell type;Code;Coupled;Coupling;Drosophila genus;ELAV protein;Event;Exons;Genes;genome-wide;Human;in vivo;insight;Investigation;Length;Maps;Messenger RNA;Modeling;Molecular;mRNA Precursor;Nature;neural;Neurons;Organism;Polyadenylation;programs;Property;Protein Isoforms;Proteins;Reporter;Research;RNA;RNA Processing;RNA Splicing;RNA-Binding Proteins;Site;Techniques;Technology;Testing;Testis;Tissues;tool;Transcript;Transcription Initiation Site;transcriptome sequencing

PROJECT_TITLE: Scope and mechanism of coordinated alternative splicing and alternative polyadenylation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-K(55)R]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Data Science;Digestive Diseases;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Orphan Drug;Pancreatic Cancer;Precision Medicine;Rare Diseases

PHR: Core C (Computational Core) - Project Narrative In addition to traditional computational and statistical support, the Computational Core provides P01 investigators with the needed expertise and infrastructure critical to conducting the proposed studies and validating the results. We collaborate with P01 Projects from designing the experiments, selecting experimental samples, formulating hypothesis, and validating the experimental results. The ultimate focus of our efforts is to assist in identifying potential targets that can result in new therapies for patient.

PI_NAMEs: FUTREAL, PHILLIP ANDREW (contact)

PROJECT_TERMS: Address;advanced analytics;Advanced Malignant Neoplasm;Algorithms;Archives;Automobile Driving;Bar Codes;base;Behavior;Big Data;Big Data Methods;Bioinformatics;Biology;biomarker discovery;Cancer cell line;cancer genome;cancer genomics;cancer immunotherapy;cancer initiation;Catalogs;Cell Line;Cells;Clinical Data;Collaborations;Computer Analysis;computer infrastructure;Computer software;computerized data processing;Data;Data Analyses;data analysis pipeline;data imputation;data modalities;Data Set;Data Sources;Dedications;differential expression;disorder subtype;empowerment;Encyclopedias;Epigenetic Process;experience;Experimental Designs;experimental study;Fibroblasts;flexibility;Formulation;Gene Expression;Generations;Genes;Genetic;genomic data;Genomics;Genotype;Goals;Human;in silico;in vivo;Individual;Infrastructure;innovation;insight;International;Label;large datasets;Malignant Neoplasms;Messenger RNA;model organism;Modeling;Molecular;Nature;next generation sequence data;next generation sequencing;novel therapeutics;Pancreatic Ductal Adenocarcinoma;Pathway interactions;Patients;Phenotype;Population;power analysis;predictive marker;Production;Public Domains;Quality Control;Records;Recovery;Research;Research Personnel;response;Retrieval;RNA;Sampling;Scanning;screening;single cell analysis;single-cell RNA sequencing;software development;Somatic Mutation;Special needs;Specimen;Statistical Data Interpretation;Technology;The Cancer Genome Atlas;Time;Tissues;tool;transcriptomics;tumor;tumor growth;tumor initiation;tumor microenvironment;Tumor-Infiltrating Lymphocytes;University of Texas M D Anderson Cancer Center;Validation;Walking;Work

PROJECT_TITLE: Core C-Computational Core


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Social Determinants of Health

ORG_CITY: MINNEAPOLIS

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE This randomized controlled trial aims to improve T1D care in East African youth age 4-26 years by testing the hypothesis that enabling patients to continuously monitor glucose levels with flash CGM will improve glucose time-in-range, and that this therapy will be cost effective in the setting of a low-resource country.

PI_NAMEs: MORAN, ANTOINETTE M. (contact)

PROGRAM_OFFICER_NAME: THORNTON, PAMELA L

PROJECT_TERMS: Acute;African;Age;Anti-HIV Agents;Area;Attention;Blinded;Blood Glucose Self-Monitoring;Caring;Child;Childhood;Chronic;Client satisfaction;Clinical;Clinical Research;cohort;Communication;Communities;Complications of Diabetes Mellitus;Continuous Glucose Monitor;Control Groups;Cost Analysis;cost effective;Country;Data;data integrity;design;diabetes control;diabetes education;Diabetes Mellitus;diabetes mellitus therapy;diabetes risk;Distress;Education;Educational workshop;effective therapy;Endocrinologist;Ensure;Ethics;experience;Family;Glucose;Glycosylated hemoglobin A;Goals;Good Clinical Practice;health care disparity;Health Personnel;high risk;HIV/AIDS;Hour;Human;Hypoglycemia;improved;Income;Individual;Insulin;Insulin-Dependent Diabetes Mellitus;Knowledge;Low income;Measurement;Measures;Medical;Mentors;Metabolic Control;Minnesota;Monitor;Outcome;Outcome Measure;Patient Education;Patient Participation;Patients;Pediatric Research;Phase;Pilot Projects;primary outcome;programs;Protocols documentation;Quality of life;randomized, clinical trials;Randomized, Controlled Trials;Research;Resource-limited setting;Resources;Scanning;Services;skills;societal costs;System;Technology;test strip;Testing;Time;Training;Uganda;Universities;Variant;Visit;Youth

PROJECT_TITLE: Diabetes in African Youth: Improving Glucose Time-In-Range

STUDY_SECTION: HSDO

STUDY_SECTION_NAME: Human Studies of Diabetes and Obesity Study Section[HSDO]


ADMINISTERING_IC: AI

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Genetics;HIV/AIDS;Infectious Diseases;Lung;Orphan Drug;Rare Diseases;Tuberculosis

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE Project Narrative Tuberculosis (TB) is the leading cause of death worldwide among people living with HIV/AIDS, and drug-resistant TB HIV is increasing in South Africa. Medication adherence and retention in care are critical components of the care continuum and predict TB cure and survival. This proposal seeks to understand local barriers and determinants for adherence and retention in South Africa, implement an innovative community-based intervention, and evaluate the effect of the intervention on clinical outcomes and patient barriers to adherence and retention.

PI_NAMEs: LARSEN, MICHELLE H (contact);O'DONNELL, MAX

PROGRAM_OFFICER_NAME: LAUGHON, BARBARA E

PROJECT_TERMS: Adherence;Antibiotics;Antimycobacterial Agents;Automobile Driving;bacterial resistance;Bayesian Modeling;Bioenergetics;Bioinformatics;Biological Assay;Cause of Death;Cellular biology;Clinical;clinical epidemiology;Clinical Microbiology;clinical sequencing;clinically relevant;cohort;Collaborations;community intervention;Continuity of Patient Care;cost;Critical Care;Data;Development;Dose;Drug Monitoring;drug repurposing;Drug resistance;drug resistance development;Drug resistance in tuberculosis;efflux pump;Electronics;Engineering;Enrollment;Epidemiology;fitness;flexibility;Generations;Genetic;Genetic Transcription;genome sequencing;genomic data;Genomics;Genotype;global health;HIV/AIDS;HIV/TB;improved;Incidence;Infrastructure;innovation;Intermediate resistance;intervention effect;Lead;Link;Measures;medication compliance;Metabolic;Metabolic Pathway;Metabolism;Monitor;mortality;multidisciplinary;Multidrug-Resistant Tuberculosis;Mutation;mycobacterial;Mycobacterium tuberculosis;National Institute of Allergy and Infectious Disease;novel;Outcome;patient-level barriers;Patients;Persons;Pharmaceutical Preparations;Phenotype;Phylogenetic Analysis;pill;Population;population based;Predisposition;preservation;pressure;prevent;prospective;Prospective Studies;Public Health;recruit;Regimen;Resistance;resistance mechanism;resistant strain;response;Sampling;Scientist;South Africa;Sputum;Techniques;Testing;Time;tool;translational approach;transmission process;Treatment Failure;Treatment outcome;Tuberculosis;tuberculosis drugs;tuberculosis treatment;United States National Institutes of Health;Variant;whole genome

PROJECT_TITLE: Advanced Genotypic and Phenotypic monitoring of Drug Resistant TB to Improve TB Treatment Outcomes

STUDY_SECTION: CRFS

STUDY_SECTION_NAME: Clinical Research and Field Studies of Infectious Diseases Study Section[CRFS]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: COLUMBIA UNIV NEW YORK MORNINGSIDE

PHR: PROJECT NARRATIVE Functional tissues and organs are generated during embryonic development by the movements and behaviors of cells. The work we propose will greatly enhance our understanding of how individual cell behaviors are coordinated to help generate complex tissue structure. Because the basic cell biological mechanisms are highly conserved from flies to humans, this work will shed light on how improper regulation of these processes results in disease states such as birth defects and cancer and may enable new therapeutic strategies.

PI_NAMEs: KASZA, KAREN  (contact)

PROGRAM_OFFICER_NAME: WELLS, MELISSA LYNN

PROJECT_TERMS: Address;Adhesives;Architecture;Award;Biochemical;Biological;biological systems;cell behavior;Cells;Complex;Congenital Abnormality;Development;Disease;Drosophila melanogaster;Embryonic Development;Epithelium;fly;Foundations;Genetic;Goals;Human;human disease;In Vitro;in vivo;Individual;innovation;insight;Malignant Neoplasms;Mechanics;model organism;Modeling;Molecular;Morphogenesis;Movement;Multicellular Process;new technology;novel strategies;novel therapeutic intervention;Organ;Process;programs;Proteins;Regulation;Research;self organization;Shapes;Structure;Techniques;Technology;Therapeutic;Tissues;tool;Work

PROJECT_TITLE: Mechanisms coordinating cell behaviors within tissues during development

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: Boulder

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF COLORADO

ORG_STATE: CO

PHR: Project Narrative This project directly addresses the family planning goals of Healthy People 2020. It does so by investigating the impact of increased access to contraception provided by the Colorado Family Planning Initiative on reducing fertility, especially of young women, and on women's and men's later economic outcomes and human capital accumulation. Its results will contribute to establishing evidence-based policies to promote health.

PI_NAMEs: STEVENSON, AMANDA JEAN (contact)

PROGRAM_OFFICER_NAME: POPKIN, RONNA

PROJECT_TERMS: 3-Dimensional;Abortion Rates;Address;adjudication;Age;age related;aged;American;Area;Calendar;Censuses;Characteristics;child bearing;Childbirth;Clinic;Code;Colorado;Community Surveys;Contraceptive methods;Data;Data Set;Dedications;Demographic Analyses;Demography;design;Documentation;economic outcome;Economics;Education;Employment;empowerment;Enrollment;Ethnic Origin;Etiology;evidence base;experimental study;Exposure to;falls;Family;Family Planning;Family Planning Policy;Family Planning Programs;Fertility;Fertility Rates;Funding;Geographic Locations;Geography;Goals;Health Policy;Health Promotion;Healthy People 2020;high school;Household;human capital;improved;Income;Individual;Journals;late life;Life Cycle Stages;Link;longitudinal dataset;Measurement;Measures;Mediating;Medicaid eligibility;men;Methods;Natural experiment;Oral;Outcome;Paper;parity;Persons;Pilot Projects;Policies;Population;Poverty;programs;Public Policy;Publishing;Quasi-experiment;Race;Records;Reproduction;reproductive;Research;Research Design;Research Personnel;Secure;Shock;social;Social Policies;Socioeconomic Status;socioeconomics;Source;Stream;Surveys;Taxes;Testing;Time;trend;United States;Variant;Vital Statistics;Woman;young woman

PROJECT_TITLE: Increased access to highly effective contraception: an opportunity dividend?

STUDY_SECTION: SSPB

STUDY_SECTION_NAME: Social Sciences and Population Studies B Study Section[SSPB]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Genetics;Hematology;Human Genome;Lung;Orphan Drug;Pediatric;Precision Medicine;Prevention;Pulmonary Hypertension;Rare Diseases

ORG_CITY: INDIANAPOLIS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: PUBLIC HEALTH RELEVANCE STATEMENT Pulmonary hypertension (PH) is a serious, potentially life-threatening disorder affecting the blood vessels of the lung, which can lead to heart failure. Its causes are complex and not well understood. Hereditary hemorrhagic telangiectasia (HHT) is a related inherited abnormality of the blood vessels that can lead to serious bleeding, including strokes, and can also cause PH. This study will characterize the genetic changes that predispose to PH and HHT, and test new therapeutic approaches to correct these defects. The long term goals are to better understand what causes pulmonary vascular disease and who is most at risk, in order to improve diagnosis, identify new therapies and work towards disease prevention.

PI_NAMEs: ALDRED, MICHEALA A (contact)

PROGRAM_OFFICER_NAME: SUTLIFF, ROY L

PROJECT_TERMS: Affect;Arteriovenous malformation;Award;Blood;Blood Cells;Blood Vessels;Bone Morphogenetic Proteins;Brain;Cardiac Catheterization Procedures;Catheters;Cells;Chromosome abnormality;Complex;Data;Defect;Diagnosis;diagnostic signature;Disease;Disease Progression;disorder prevention;DNA analysis;DNA Damage;Endothelial Cells;Etiology;Evolution;Funding;Genetic;Genetic Variation;Genomics;Germ Lines;Goals;Heart failure;Hemorrhage;Hereditary hemorrhagic telangiectasia;improved;In Vitro;Inherited;innovation;Leadership;Life;Liver;Lung;Molecular;Morbidity - disease rate;mouse model;Mutation;National Heart, Lung, and Blood Institute;next generation sequencing;Nonsense Mutation;novel;novel diagnostics;novel therapeutic intervention;novel therapeutics;Orphan Drugs;Pathway interactions;Patients;Pharmaceutical Preparations;Precision therapeutics;Prevention;prognostic signature;programs;public health relevance;pulmonary arterial pressure;pulmonary artery endothelial cell;Pulmonary Hypertension;pulmonary vascular disorder;pulmonary vascular remodeling;Reactive Oxygen Species;Research;Research Personnel;Resolution;response;Ribosomes;right ventricular failure;Risk;Signal Pathway;Signaling Protein;single cell sequencing;small molecule;Somatic Mutation;Stroke;Structure of parenchyma of lung;Technology;Telangiectasis;Testing;Vascular Diseases;Vascular remodeling;Work

PROJECT_TITLE: Genomics of Pulmonary Vascular Disease


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Immunization;Infectious Diseases;Influenza;Lung;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Narrative The goal of this proposal is to dissect the roles of tissue-resident CD4 helper T cells in the development of protective mucosal immunity following influenza infection or immunization with a “universal” influenza vaccine candidate, Nanovax. In addition, this application is designed to use genetic approaches to test whether selective promotion of tissue-resident helper T cell responses will simultaneously boost mucosal memory B cell and T cell responses following influenza infection or after immunization with Nanovax.

PI_NAMEs: SUN, JIE  (contact)

PROGRAM_OFFICER_NAME: ARNOLD, MICHELLE MARIE

PROJECT_TERMS: Ablation;Address;Antigen Presentation;ATAC-seq;B-Lymphocytes;BCL6 gene;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Maintenance;Cells;Cellular Immunity;Cessation of life;Chronic;Cues;cytokine;Data;design;Development;Epigenetic Process;Epitopes;Evolution;Exhibits;Future;Gene Expression;Generations;Genes;Genetic;genetic approach;Goals;Helper-Inducer T-Lymphocyte;Humoral Immunities;Hybrids;Immune response;Immunity;Immunization;In Situ;Infection;Influenza;Influenza A virus;influenza infection;Influenza Therapeutic;Influenza vaccination;influenza virus strain;influenzavirus;Invaded;Lung;Maintenance;Mediating;Memory;Memory B-Lymphocyte;migration;Molecular;Mucosal Immunity;mucosal site;mucosal vaccination;mucosal vaccine;Mucous Membrane;novel;pathogen;Pathway interactions;Plasma;Population;Property;protein expression;Respiratory Mucosa;Respiratory System;response;Role;secondary infection;secondary lymphoid organ;Shapes;Structure of germinal center of lymph node;Structure of parenchyma of lung;T cell response;T-Lymphocyte;Testing;Therapeutic;Tissues;transcription factor;transcriptome sequencing;universal influenza vaccine;universal vaccine;vaccine candidate;Viral;Virus;Virus Diseases

PROJECT_TITLE: Roles of tissue-resident helper T cells in mucosal immunity against influenzainfection

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IMM-T(57)]


ORG_CITY: PROVIDENCE

ORG_DEPT: CHEMISTRY

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: Project Narrative The fields of reactive sulfur species (including hydrogen sulfide, sulfane sulfurs, hydrogen polysulfides, persulfides, etc.) have been rapidly growing in recent years. Understanding their fundamental chemistry and property is the prerequisite for understanding their physiological and clinical potentials. In this R35 application, we plan to establish a research program focusing on these sulfur species. We will study the chemistry and chemical biology of several representative species including hydrogen sulfide, persulfides, and polysulfides. Four distinct projects related to their generation, detection, reactions, and uses are proposed.

PI_NAMEs: XIAN, MING  (contact)

PROGRAM_OFFICER_NAME: ASLAN, KADIR

PROJECT_TITLE: Explore the Chemistry and Chemical Biology of Reactive Sulfur Species


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences

ORG_DEPT: ORTHOPEDICS

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: The neurotransmitter dopamine plays critical roles in circuits that generate voluntary movement and process rewarding stimuli; because these circuits have large influence on behavior, affect, and cognition, dopamine signaling is targeted for the treatment of many neurological and psychiatric diseases, including Parkinson's Disease, schizophrenia, attention disorders, and obsessive-compulsive disorder. We will use a powerful experimental model - a microscopic animal that uses dopamine to generate simple behaviors - to discover genes required for the proper regulation of dopamine release and to determine how dopamine causes lasting changes in neural circuits that control behavior. Understanding the molecular and circuit mechanisms required for dopamine signaling will advance understanding of diseases linked to dysfunction of dopamine signaling in the brain and will generate opportunities to develop new approaches for their treatment.

PI_NAMEs: RAMANATHAN, SHARAD ;RINGSTAD, NIELS  (contact)

PROGRAM_OFFICER_NAME: CHURN, SEVERN BORDEN

PROJECT_TERMS: Acceleration;addiction;Address;Affect;Animals;Attention;Behavior;behavior change;Behavior Control;Behavioral;Behavioral Genetics;behavioral response;Brain;Caenorhabditis elegans;Calcium;Cells;cellular targeting;Cognition;Data;design;Desire for food;Disease;Dopamine;Dopamine Receptor;dopamine system;dopaminergic neuron;DRD2 gene;drug of abuse;Drug Targeting;Event;Experimental Models;experimental study;Family;Food;Functional disorder;Functional Imaging;G-Protein-Coupled Receptors;GABA-A Receptor;gene discovery;Genetic;Human;in vivo;Individual;innovation;Interneurons;Ion Channel Gating;Ligand Binding;Ligands;Link;Mediating;Mental disorders;Methods;Microscopic;Microscopy;Molecular;Molecular Genetics;Molecular Mechanisms of Action;Movement;Movement Disorders;mutant;Nematoda;Nervous System;Nervous System Disorder;neural circuit;Neurobiology;neurochemistry;Neuromodulator;Neurons;neuropsychiatric disorder;neuroregulation;Neurotransmitters;novel;novel strategies;Obsessive-Compulsive Disorder;Optical Instrument;optogenetics;Parkinson Disease;Physiology;Play;postsynaptic;postsynaptic neurons;Potassium Channel;presynaptic;Process;programs;Property;receptor;Receptor Signaling;Regulation;Research;response;Rewards;Role;Schizophrenia;Signal Transduction;Speed;Stereotyping;Stimulus;Synapses;System;targeted treatment;Techniques;therapeutic target;tool;Transcript;TRP channel

PROJECT_TITLE: Mechanisms of Synaptic Dopamine Signaling in the Control of Behavior

STUDY_SECTION: SYN

STUDY_SECTION_NAME: Synapses, Cytoskeleton and Trafficking Study Section[SYN]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE The goal of this project is to advance brain function studies through broad dissemination of Echo Planar Time- resolved Imaging (EPTI) technology as the next-generation fMRI acquisition tool, which can provide higher efficiency, sensitivity and specificity for fMRI. We will assemble and disseminate the whole EPTI acquisition, reconstruction and processing package developed in different vendor platforms and in open-source and cross- vendor frameworks to the neuroimaging community.

PI_NAMEs: WANG, FUYIXUE  (contact)

PROGRAM_OFFICER_NAME: TRZCINSKI, NATALIE KATHERINE

PROJECT_TERMS: Acceleration;Address;Algorithms;Area;Brain;Brain imaging;Brain Stem;Communities;Computer software;contrast imaging;Data;Data Correlations;data format;Data Set;design;Dropout;Echo-Planar Imaging;Ensure;Evolution;Excision;Functional Magnetic Resonance Imaging;Goals;Human;Image;image reconstruction;Imaging technology;Immune;improved;interest;Investigation;Magnetic Resonance Imaging;Measures;Methods;Motion;neuroimaging;Neurons;next generation;Noise;non-invasive imaging;open data;open source;peer;Performance;Physiologic pulse;Physiological;Procedures;Process;Protocols documentation;Publishing;quality assurance;Quality Control;reconstruction;Research;Resolution;Resources;Rest;Sampling;Sensitivity and Specificity;sharing platform;Signal Transduction;Site;Slice;spatiotemporal;Specificity;Techniques;Technology;Temporal Lobe;Testing;Time;tool;user-friendly;Variant;Vendor

PROJECT_TITLE: Advancing fMRI Acquisition through Dissemination of EPTI- An Efficient Distortion-Free Multi-Contrast Imaging Technology


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: PROJECT NARRATIVE Human population history is of importance to public health because it determines the genetic variants that individuals and populations inherit, which in turn make some people more or less susceptible to disease. The exponential increase ancient DNA data—from 0 genomes a decade ago to more than 10000 today—creates extraordinary new opportunities, but methods for analysis have not caught up to the data. This grant will support the development of a complete toolkit for using ancient DNA for studying biology and history, and in addition to papers describing these methods and their application, will produce two major resources: publicly available software and a high quality reprocessed version of the world's ancient DNA data.

PI_NAMEs: REICH, DAVID E (contact)

PROGRAM_OFFICER_NAME: ARGUELLO, ALEXANDER

PROJECT_TERMS: Address;Admixture;Adoption;Affect;Africa;African American population;African ancestry;analytical method;Asia;Awareness;Biology;Communities;Computer software;computerized tools;Data;Data Set;detection method;Development;Disease;disorder risk;DNA;Europe;Event;Farm;flexibility;Funding;gene discovery;Genes;Genetic Drift;Genetic Predisposition to Disease;Genetic Recombination;genetic variant;Genetic Variation;Genome;genome-wide;Genomics;Genotype;Grant;Graph;Growth;heterogenous data;Human;Human Biology;human population study;improved;Individual;Inherited;insight;Iran;Laboratories;Learning;Link;Malignant neoplasm of prostate;Manuals;Maps;Medical Genetics;method development;Methodology;Methods;Modeling;Modernization;Movement;Natural Selections;Near East;Northern Europe;novel;Paper;Persons;Population;Predisposition;Process;programs;Protocols documentation;Public Health;Publications;Publishing;Recording of previous events;Reporting;Research;Resolution;Resources;Risk Factors;Running;Sex Bias;Shapes;simulation;Southeastern Asia;Space Models;statistics;Structure;study population;synergism;Testing;tool;Trees;user-friendly;Variant;Work

PROJECT_TITLE: Advanced tools for using ancient DNA to study biology and history


ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Interferons (IFNs) exhibit important antitumor effects in vitro and in vivo and play key roles in the immune surveillance against cancer. We have identified a novel signaling mechanism activated by the Type I IFN receptor, involving the kinase ULK1. This IFN-controlled signaling cascade is unrelated to the effects of ULK1 on autophagy and was previously unknown. The proposal will precisely define the role of ULK1 signals in the induction of the biological effects of IFNs in myeloproliferative neoplasms (MPNs) and will identify upstream and downstream effectors of the pathway. Ultimately, the studies of this proposal can lead to the development of novel approaches for the treatment of MPNs and other malignancies.

PI_NAMEs: PLATANIAS, LEONIDAS C. (contact)

PROGRAM_OFFICER_NAME: KLAUZINSKA, MALGORZATA

PROJECT_TERMS: Antineoplastic Agents;antitumor effect;Autophagocytosis;Biological;cancer cell;Cells;Characteristics;Clinical;Clinical Trials;cohort;Cohort Effect;Complex;CRISPR/Cas technology;cytokine;design;Development;Disease remission;Elements;Event;Exhibits;experimental study;Gene Expression;gene induction;Generations;Genes;Genetic Transcription;Hematopoietic;Hemorrhagic Thrombocythemia;Immune response;Immunologic Surveillance;In Vitro;in vivo;inhibitor;Interferon Activation;Interferon Receptor;Interferon Type I;Interferons;Janus kinase;Knock-out;Malignant - descriptor;Malignant Neoplasms;MAP Kinase Gene;Maps;Mediating;Methodology;Molecular;mouse model;Mus;mutant;Mutation;Myelofibrosis;Myeloproliferative disease;Natural Immunity;Noble Gases;novel;novel strategies;novel therapeutic intervention;novel therapeutics;operation;p38 Mitogen Activated Protein Kinase;Pathway interactions;Patients;pharmacologic;Phosphorylation Site;Phosphotransferases;Play;Polycythemia Vera;promoter;Property;Proteins;Proteomics;receptor;Regulation;Resistance;response;ROCK1 gene;Role;Signal Transduction;Specificity;Structure;System;Therapeutic;Therapeutic Effect;Time;tumor;type I interferon receptor;upstream kinase;Work

PROJECT_TITLE: Signal Transduction of Type 1 Interferons in Malignant Cells

STUDY_SECTION: CAMP

STUDY_SECTION_NAME: Cancer Molecular Pathobiology Study Section[CAMP]


NIH_SPENDING_CATS: Aging;Cardiovascular;Clinical Research;Heart Disease;Menopause;Neurosciences;Prevention;Women's Health Research

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

PHR: PROJECT NARRATIVE Women who experience hot flashes are at greater risk for hypertension and other cardiovascular disease. Neurovascular control mechanisms are likely to play an important role in this relationship. As such, these studies are designed to provide a major step forward in understanding the link between hot flashes and neurovascular dysfunction and, by extension, cardiovascular disease in women.

PI_NAMEs: BAKER, SARAH ELIZABETH (contact)

PROGRAM_OFFICER_NAME: REDMOND, NICOLE

PROJECT_TERMS: Adrenergic Agents;Aging;Area;Arteries;Baroreflex;Blood;Blood flow;Blood Vessels;Brain;Carbon Dioxide;Cardiovascular Diseases;cardiovascular disorder risk;career;career development;cerebrovascular;Cerebrum;Clinical Trials;clinically relevant;Complement;Cutaneous;design;Development;diaries;effective intervention;Endothelium;Evaluation;experience;experimental study;Feeling;Frequencies;Functional disorder;Goals;heart rate variability;Hot flushes;Hypertension;Impaired cognition;Impairment;Incidence;innovation;insight;Intervention;Knowledge;Learning;Life;Link;Lipids;Measures;Mediating;Menopause;Mentorship;Midlife women;Monitor;Mood Disorders;Muscle;Nerve;neurotransmitter release;neurovascular;novel;Obesity;Peripheral;Phenotype;Physiological;Physiology;Play;prevent;Prevention;Property;Regulation;Research;Resistance;Resolution;response;Rest;Risk;Risk Factors;Role;Running;Skeletal Muscle;Skin;Sleep;Sleep Disorders;Smooth Muscle;Stimulus;stressor;Sweating;System;Technical Expertise;Techniques;Tissues;Training;Vascular Endothelium;Vasoconstrictor Agents;Vasodilation;Vasodilator Agents;vasomotor symptoms;White Matter Hyperintensity;Woman;Women's Health;Work

PROJECT_TITLE: Hot Flashes and Neurovascular Function in Women

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(JA)]


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE The proposed Utah Clinical and Translational Science Institute K12 career development training program is intended to build a foundation for junior investigators in the health sciences to achieve fulfilling careers in translational research and science. Scholars will receive 2 to 3 years of support and training opportunities designed to ensure that they develop the characteristics of clinical and translational researchers through novel curricular advancements that focus on translational science and communication skills.

PI_NAMEs: MURTAUGH, MAUREEN A (contact);NYGAARD, INGRID E

PROGRAM_OFFICER_NAME: DIBELLO, ANTHONY THOMAS

PROJECT_TERMS: Accountability;Award;biomedical informatics;Biometry;career;Career Choice;career development;Characteristics;Clinical;Clinical Research;Clinical Sciences;Clinical Trials;Collaborations;Communication;community collaboration;community engagement;curriculum development;Degree program;design;early-career faculty;Education Projects;Elements;Engineering;Epidemiology;Evaluation;experience;Faculty Workshop;Foundations;Grant;Health Sciences;Immersion;implementation science;innovation;Institution;instructor;Leadership;Medicine;Mentored Clinical Scientist Development Program;Mentors;Modeling;novel;Outcome Measure;Program Development;programs;recruit;Request for Applications;Research;research data dissemination;Research Design;Research Ethics;Research Personnel;Research Support;Services;skills;success;Texas;Training;training opportunity;Training Programs;Translational Research;translational scientist;Universities;Utah;virtual;Writing

PROJECT_TITLE: CTSA K12 Program at University of Utah: Early Career Faculty Development Program


ORG_CITY: MEMPHIS

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

ORG_STATE: TN

PI_NAMEs: GREEN, DOUGLAS R. (contact)

PROGRAM_OFFICER_NAME: SINGLETON, KENTNER L

PROJECT_TERMS: Ablation;Adult;Alleles;Animals;Apoptosis;Apoptotic;autoimmune lymphoproliferative syndrome;Biochemistry;Biology;Bone Marrow;Calnexin;CASP8 gene;Caspase;Cell Death;Cell Death Process;Cells;Cellular biology;Collaborations;Comet Assay;Communities;Complex;cytokine;Cytosol;Data;Defect;design;Detection;Development;Disease;DNA;DNA Damage;DNA Repair;Embryo;experimental study;Generations;Genetic;Genetic Models;Homeostasis;In Vitro;in vivo;Individual;Inflammation;Inflammatory;insight;Intention;Interferons;Investigation;Learning;Ligands;LoxP-flanked allele;Mediating;metabolomics;Methods;Mus;mutant;Mutation;novel;Paper;Pathogenesis;Pathway interactions;Perinatal mortality demographics;Phenotype;Phosphotransferases;Play;prevent;Prevention;Process;programs;Publications;Publishing;recruit;Regulation;Repression;Research;RIPK1 gene;RIPK3 gene;Role;Signal Transduction;Stains;Stimulator of Interferon Genes;Syndrome;Techniques;Tissues;TNF gene;TNFRSF6 gene;TNFSF6 gene;tool

PROJECT_TITLE: Survival Function of the Fadd-Caspase-8-Flip Complex - MERIT Extension

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Autoimmune Disease;Cancer;Colorectal Cancer;Complementary and Integrative Health;Dietary Supplements;Digestive Diseases;Genetics;Inflammatory Bowel Disease;Microbiome;Nutrition;Prevention

ORG_CITY: PHILADELPHIA

ORG_NAME: RESEARCH INST OF FOX CHASE CAN CTR

ORG_STATE: PA

PHR: Project Narrative  Patients with ulcerative colitis often develop folate deficiencies and require supplementation with folic acid. The cancer preventive properties of folic acid remain controversial and few studies have focused on its activity in the setting of inflammatory bowel disease. An in-depth analysis of the impact of folic acid supplementation (high dietary intake) on risk for colitis-associated colorectal cancer is essential to ensure its safety and inform guidelines for its use in patients with ulcerative colitis who are known to be at increased risk for colorectal cancer.

PI_NAMEs: CLAPPER, MARGIE L. (contact)

PROGRAM_OFFICER_NAME: EMENAKER, NANCY J

PROJECT_TERMS: 16S ribosomal RNA sequencing;Acids;Address;Adult;Age;Apoptosis;Architecture;Area;Attention;Bacteria;Biological Markers;Cell Cycle Progression;Cell Line;Cells;Chronic;Clinical;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;Colectomy;Colitis;colitis associated cancer;Colitis associated colorectal cancer;Colon;colon cancer risk;colon carcinogenesis;Colon Carcinoma;Colonic inflammation;Colonic Neoplasms;Colorectal Cancer;colorectal cancer risk;Colorectal Neoplasms;CRISPR/Cas technology;cyclooxygenase 2;cytokine;Data;Development;dextran sulfate sodium induced colitis;Diagnosis;Diet;Dietary Administration;Dietary intake;Disease Management;DNA biosynthesis;Dose;Dysplasia;Engineering;Ensure;Epithelial Cells;Event;experimental study;Exposure to;Face;Flare;Folic Acid;Folic Acid Deficiency;folic acid supplementation;Gatekeeping;Gene Expression;Genetic Transcription;Goals;Guidelines;gut inflammation;gut microbiota;high risk population;Human;illness length;In Vitro;in vivo;in vivo evaluation;Incidence;Individual;Inflammation;Inflammatory;Inflammatory Bowel Diseases;insight;Intake;Interleukin-6;Intervention;Intestines;Maintenance Therapy;Malabsorption Syndromes;Malignant Epithelial Cell;Malignant Neoplasms;Measures;Mediating;Mesalamine;metagenomic sequencing;metaplastic cell transformation;microbiome;Molecular;Mucositis;Mucous Membrane;Mus;mutant;Mutation;neoplastic cell;Nuclear;Oncogenic;p65;Pathway interactions;Patients;Pharmaceutical Preparations;Population;prevent;Prevention strategy;Preventive;primary endpoint;Property;response;Ribosomal RNA;Risk;Safety;Serum Folate Level;Severities;Signal Transduction;Standardization;Suggestion;Surface;Testing;Therapeutic;Time;TP53 gene;transcriptome sequencing;tumor;Tumor Burden;Tumor Promotion;tumorigenesis;Ulcerative Colitis;Vitamin B Complex;Western Blotting

PROJECT_TITLE: Folic Acid Supplementation and Colitis-associated Colon Carcinogenesis

STUDY_SECTION: CPSS

STUDY_SECTION_NAME: Cancer Prevention Study Section[CPSS]


NIH_SPENDING_CATS: Nutrition;Obesity

ORG_CITY: DALLAS

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: Project Narrative The proposed research aims to define the physiological role of a novel adipocyte-specific protein CLSTN3B in determining the lipid storing capacity of adipocytes and the detailed molecular mechanism underlying this function. The knowledge obtained from this research is relevant to public health because factors affecting the lipid storing capacity of adipocytes are closely associated with an individual’s susceptibility to developing metabolic complications as a result of extra-adipose lipid deposition under the condition of caloric overload. Thus, the proposed research is relevant to the NIDDK’s mission of seeking fundamental knowledge about endocrine and metabolic diseases and using that knowledge to improve people’s health and quality of life.

PI_NAMEs: ZENG, XING  (contact)

PROGRAM_OFFICER_NAME: HAFT, CAROL R

PROJECT_TERMS: Ablation;Adipocytes;Adipose tissue;Affect;Animal Model;Animals;Binding;Biochemical;Biochemistry;Biological Assay;Body mass index;Body Weight;Brown Fat;C-terminal;Cardiovascular Diseases;Cell model;Cells;Cellular biology;Communication;Defect;density;Deposition;design;Disease;Dissection;Elements;Endocrine System Diseases;Endoplasmic Reticulum;Event;Extravasation;feeding;Genetic Models;Goals;Health;High Fat Diet;Impairment;improved;In Vitro;Individual;innovation;insight;Insulin Resistance;Knockout Mice;Knowledge;Lipid Binding;Lipids;Maintenance;Mediating;Metabolic;Metabolic Diseases;metabolic phenotype;Mission;Molecular;mouse model;Mus;N-terminal;Names;National Institute of Diabetes and Digestive and Kidney Diseases;Nerve;nerve supply;new therapeutic target;non-alcoholic fatty liver disease;Non-Insulin-Dependent Diabetes Mellitus;novel;obese patients;Obesity;Obesity associated disease;Organ;Organelles;Outcome;Pathogenesis;Pathway interactions;Persons;Phenotype;Phospholipids;Physiological;Physiology;Play;Population;Predisposition;Process;Proteins;Public Health;Quality of life;reconstitution;recruit;Research;Risk;Risk Factors;Role;Severities;Site;Structure;Surface;System;Testing;therapeutic target;Transgenic Mice;Transmembrane Domain;Variant;Wild Type Mouse;Work

PROJECT_TITLE: Mechanistic Connection between Interorganellar Communication and Obesity-associated Diseases

STUDY_SECTION: POMD

STUDY_SECTION_NAME: Pathophysiology of Obesity and Metabolic Disease Study Section[POMD]


ORG_CITY: SAINT LOUIS

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: The inductive and morphogenetic processes that establish the vertebrate body plan during gastrulation must be coordinated in space and time to ensure normal development. We are investigating the molecular mechanisms through which the key regulators of gastrulation, including Gpr125 adhesion G Protein- Coupled Receptor, Wnt/Planar Cell Polarity and Dachsous, interact to coordinate gastrulation movements with embryo patterning. We will also take an unbiased genetic approach to identify new essential regulators of gastrulation. As mutations in the components of these pathways cause miscarriages, birth defects and diseases, our studies can advance their understanding, diagnosis and facilitate development of therapies.

PI_NAMEs: SOLNICAKREZEL, LILIANNA  (contact)

PROJECT_TERMS: Adhesions;Award;Behavior;Cadherins;Cell Shape;Cells;Complex;Congenital Abnormality;Development;Diagnosis;Disease;Embryo;embryo tissue;embryonic cleavage;Embryonic Development;Ensure;Experimental Genetics;Funding;Future;G-Protein-Coupled Receptors;Gastrula;gastrulation;gene product;Genetic;genetic approach;Genetic Screening;genome editing;Germ Layers;Goals;Impairment;insight;Investments;Membrane;Mesenchymal;Microtubules;Mission;Molecular;Morphogenesis;Morphology;Movement;Mutation;Pathway interactions;Pattern;planar cell polarity;polarized cell;Process;Proteomics;receptor;Research;Research Personnel;Shapes;Signal Pathway;Signal Transduction;Specific qualifier value;Spontaneous abortion;Testing;therapy development;Time;tool;Work;Zebrafish

PROJECT_TITLE: Inductive and morphogenetic processes shaping the zebrafish embryonic axes


NIH_SPENDING_CATS: Neurosciences

ORG_DEPT: BIOLOGY

PHR: Nerve cells communicate via synaptic transmission, but defects in this process can lead to diseases of the nervous system, such as Parkinson's Disease and Alzheimer's Disease. By studying the basic processes of recycling at neuronal synapses, we hope to understand the causes of neurodegenerative diseases as well as develop novel therapies.

PI_NAMEs: JORGENSEN, ERIK M (contact)

PROGRAM_OFFICER_NAME: MATOS GALICIA, HEIDI YANICE

PROJECT_TERMS: Action Potentials;Acute;Alzheimer's Disease;Applications Grants;Area;Binding;Biological Assay;Caenorhabditis elegans;Calcium;Cell Communication;Cell membrane;Clathrin;Communication;complement C2a;complement C2b;Defect;Disease;Electron Microscopy;Endocytosis;Endosomes;enhancer-binding protein AP-2;Exhibits;Exocytosis;Failure;Freezing;Future;Health;Hippocampus;Immunofluorescence Immunologic;innovation;Lead;Measures;Mediating;Membrane;Modeling;Molecular;Motor Neurons;Mus;mutant;Mutation;Natural regeneration;Nematoda;Nervous System Disorder;Neurodegenerative Disorders;Neurons;neurotransmitter release;novel therapeutics;optogenetics;Parkinson Disease;Pharmacotherapy;Play;pressure;Process;Proteins;Rattus;recruit;Recycling;Research;Research Personnel;Resolution;Retrieval;Role;sensor;Signal Transduction;Site;Sorting;Speed;superresolution imaging;superresolution microscopy;Surface;Synapses;synaptic function;Synaptic Transmission;Synaptic Vesicles;Synaptophysin;synaptotagmin;Techniques;Tertiary Protein Structure;Testing;Time;trafficking;transmission process;Vesicle;vesicle-associated membrane protein;weapons

PROJECT_TITLE: Synaptic Function in the Nematode C. Elegans


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cocaine;Drug Abuse (NIDA only);Genetics;Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

ORG_STATE: CA

PHR: Project Narrative Substance use disorder, a disease affecting endogenous reward pathways in the brain, has a significant economic and social impact both globally and within the United States. In this proposal, we investigate an epigenetic mechanism in the medial habenula of the endogenous reward pathway related to the reinstatement of drug-seeking behavior. The medial habenula is an understudied region of the reward pathway, and investigating the epigenetic mechanisms in this brain region will shed new light on reinstatement (relapse-like behavior) and potentially identify novel mechanisms to target therapeutically.

PI_NAMEs: LYNCH, GARY S;WOOD, MARCELO ANDRES (contact)

PROGRAM_OFFICER_NAME: POLLOCK, JONATHAN D

PROJECT_TERMS: Abstinence;addiction;Adult;Affect;Animals;Behavior;Binding;Brain;Brain region;Cell Physiology;cell type;Characteristics;ChIP-seq;Choline O-Acetyltransferase;cholinergic neuron;Chromatin Structure;Chronic;Cocaine;cocaine related behaviors;cocaine seeking;Cues;Data;Deacetylase;designer receptors exclusively activated by designer drugs;Development;Disease;DNA Sequence;Dominant-Negative Mutation;Dopamine;Drug Exposure;drug of abuse;drug seeking behavior;Drug Targeting;drug use behavior;economic impact;Epigenetic Process;epigenetic regulation;Exposure to;Gene Expression;Gene Expression Regulation;Genes;Habenula;HDAC3 gene;HDAC4 gene;Histone Acetylation;Human;interpeduncular nucleus;Knowledge;Learning;Medial;Mediating;Memory;memory consolidation;memory process;Methods;Midbrain structure;Molecular;Mus;mutant;Nature;Neuronal Plasticity;Neurons;neuropsychiatric disorder;nicotine seeking behavior;Nicotine Withdrawal;Nicotinic Receptors;novel;NR4A2 gene;Nucleus Accumbens;Pathway interactions;Pharmaceutical Preparations;Physiological Processes;Physiology;Preparation;promoter;Publishing;Relapse;Repression;response;reward circuitry;Rewards;RNA Splicing;Role;Signal Transduction;Slice;Social Impacts;Substance Use Disorder;substance use treatment;Synapses;Synaptic Transmission;targeted treatment;Testing;transcription factor;transcriptome sequencing;United States;Variant;Work

PROJECT_TITLE: Epigenetic mechanisms in the medial habenula governing drug-seeking behavior


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Gene Therapy;Gene Therapy Clinical Trials;Genetics;Hematology;Immunotherapy;Lymphatic Research;Lymphoma;Orphan Drug;Rare Diseases

ORG_CITY: DUARTE

ORG_NAME: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE

PHR: PROJECT NARRATIVE Nearly half of patients with B-cell acute lymphoblastic leukemia (B-ALL) who receive CD19-directed immunotherapy ultimately fail therapy, with down-regulation or loss of the CD19 target on B-ALL cells as a prominent cause of failure. To offer alternative treatment options to these patients, we have developed genetically-engineered human immune T cells targeting the B-cell activating factor receptor (BAFF-R) on B- ALL cells, and will conduct a first-in-human trial in patients who have failed prior CD19 therapy. To further improve patient outcomes, we are also developing bispecific T cells targeting both CD19 and BAFF-R to cut off tumor’s escape routes and prevent the re-emergence of malignant cells.

PI_NAMEs: ALDOSS, IBRAHIM ;KWAK, LARRY W (contact);WANG, XIULI

PROGRAM_OFFICER_NAME: HENDERSON, LORI A

PROJECT_TERMS: Acute;Address;Adult;Affect;Aftercare;Alternative Therapies;alternative treatment;Antigen Receptors;Antigens;Autoimmune Diseases;B lymphoid malignancy;B-Cell Acute Lymphoblastic Leukemia;B-Cell Neoplasm;B-Lymphocytes;bench to bedside;bi-specific T cell engager;cancer cell;CAR T cell therapy;CD19 Antigens;CD19 gene;CD22 gene;Cell Physiology;Cell Survival;chemotherapy;Child;Childhood;chimeric antigen receptor;chimeric antigen receptor T cells;Cities;Clinical;clinical efficacy;clinical lot;Clinical Trials;Correlative Study;Cyclic GMP;cytokine;Data;Data Analyses;Development;Disease;Dose;Down-Regulation;effective therapy;Enrollment;Epitopes;experience;Failure;Fc Receptor;FDA approved;first-in-human;Generations;Genetic Engineering;Hematologic Neoplasms;high risk;Human Engineering;Immune;Immunotherapy;improved;In Vitro;in vivo;innovation;Interleukin 4 Receptor;Kinetics;Laboratory Research;Lentivirus;Ligands;Lymphoblastic Lymphoma;Lymphoid Cell;Lymphoma;Lymphoma cell;manufacture;Manuscripts;Modeling;Monoclonal Antibodies;mouse model;Multiple Myeloma;new therapeutic target;NK cell therapy;novel;novel therapeutics;Outcome;Patient Care;patient derived xenograft model;patient population;Patient-Focused Outcomes;Patients;Phase;Phenotype;Population;preclinical study;Preparation;prevent;Principal Investigator;professor;Prognosis;Property;Recommendation;Recurrent disease;Refractory;Relapse;relapse patients;Remission Induction;Reporting;Research;Research Institute;Resistance;response;Route;safety assessment;Specificity;success;Surface;T cell therapy;T memory cell;T-Lymphocyte;targeted treatment;Technology;Testing;Therapeutic Effect;timeline;Translating;Treatment Efficacy;tumor;Tumor Escape

PROJECT_TITLE: BAFF-R CAR T cell therapy for ALL

STUDY_SECTION: CONC

STUDY_SECTION_NAME: Clinical Oncology Study Section[CONC]


NIH_SPENDING_CATS: Cannabinoid Research;Drug Abuse (NIDA only);Genetics;Natural Products;Neurosciences;Substance Misuse

PHR: The proposed research will investigate the impact of THC on extracellular vesicle signaling in the brain and periphery. It is predicted that extracellular vesicles will contain differential profiles of cargo in response to varying THC exposures and in the presence of nicotine co-exposure. By providing fundamental insights into novel extracellular mechanisms with THC, findings from these studies may thereby identify biomarkers and targets for the development of efficacious therapeutics to treat dependence in humans.

PI_NAMEs: FOWLER, CHRISTIE D (contact)

PROGRAM_OFFICER_NAME: SATTERLEE, JOHN S

PROJECT_TERMS: Abstinence;Acute;Adipocytes;Alleles;Biological Markers;biomarker identification;biomarker panel;Blood;Brain;Brain region;cannabinoid receptor;Cannabinoids;Cannabis;CD81 gene;cell type;Cerebrospinal Fluid;Choroid Plexus Epithelium;Chronic;Cigarette;clinical application;CNR1 gene;CNR2 gene;Cre driver;Data;density;Dependence;Development;Disease;Dopamine;Dopaminergic Cell;dopaminergic neuron;Drug Addiction;drug of abuse;Drug usage;Epithelial Cells;extracellular;extracellular vesicles;Female;Foundations;Genetic Transcription;genome wide association study;Goals;Human;Hypermethylation;In Vitro;in vivo;Individual;innovation;insight;integration site;male;Malignant Neoplasms;marijuana use;marijuana user;Mediating;MicroRNAs;Microscopy;Mus;NCAM1 gene;neural;Neural Cell Adhesion Molecules;Neuroglia;Neurons;new therapeutic target;Nicotine;nicotine exposure;nicotine self-administration;novel;Patients;Pattern;Peripheral;Pharmaceutical Preparations;Plasma;Population;promoter;Property;Rattus;receptor;receptor expression;Research;Resistance;response;Rewards;RNA;sex;Signal Transduction;specific biomarkers;Structure of choroid plexus;Surface;Tetrahydrocannabinol;THC exposure;Therapeutic;therapeutic development;Tissues;Tobacco use;transcriptome sequencing;Transgenic Mice;uptake;Validation;Variant;Ventral Tegmental Area;vesicular release;Virus

PROJECT_TITLE: Impact of THC on Extracellular Vesicle Signaling


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

PHR: Project Narrative Lung diseases account for most of the leading causes of death in the United States and the rest of the world. Despite the need for further lung research targeted broadly at basic and clinical levels, there is a national shortage of clinically-directed scientists. This grant aims to fund a program to train postdoctoral scientists in both adult and pediatric research programs, to invest in the future of lung-related research.

PI_NAMEs: SHAUL, PHILIP W;TERADA, LANCE S (contact)

PROGRAM_OFFICER_NAME: ESPINOZA-PINTUCCI, MARISOL

PROJECT_TERMS: Biology;Disease;Lung;Training Programs

PROJECT_TITLE: TRAINING PROGRAM IN LUNG BIOLOGY AND DISEASE

STUDY_SECTION: NITM

STUDY_SECTION_NAME: NHLBI Institutional Training Mechanism Study Section[NITM(OA)]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_NAME: JESSE BROWN VA MEDICAL CENTER

PHR: Narrative: Anti-hemangiogenesis and anti-lymphangiogenesis based therapies can be used as a platform to develop drugs, that can be used to prevent or regress the growth of blood and lymphatic vessels, which are involved in the treatment of Limbal Stem Cell transplantation, cancer, organ transplants and many other disorders. The goal of this project is to elucidate how Limbal Stem Cell Deficiency injury affects corneal HA and LA in VEGFR1, R2 or R3 knockout background in order to develop molecular strategies for treating pathologic corneal disorders with dysregulated HA and LA. Through these observations, we hypothesize that a dynamic balance of multiple anti-angiogenic and anti-lymphangiogenic factors as well as inflammatory cells modulates corneal avascularity, and these factors might be regulated by vascular endothelial cell receptor VEGFR1 or R2 and lymphatic endothelial cell receptor VEGFR2 or R3.

PI_NAMEs: CHANG, JIN-HONG  (contact)

PROJECT_TERMS: Affect;angiogenesis;Angiogenesis Inhibitors;Antibodies;Antibody Therapy;Area;Binding;Blindness;Blood Vessels;Cells;Chemicals;combat;conditional knockout;Cornea;Corneal Diseases;corneal epithelium;Corneal Injury;Corneal Neovascularization;Corneal Stroma;Data;differential expression;Disease;drug development;Dryness;DsRed;Endothelial Growth Factors Receptor;enhanced green fluorescent protein;Environment;Epithelial Cells;epithelial stem cell;Epithelium;Equilibrium;Experimental Models;Explosion;Exposure to;Eye;Eye Injuries;Future;Genes;Goals;Graft Rejection;Green Fluorescent Proteins;Growth;Growth and Development function;Harvest;healing;Health;Healthcare;high risk;Human Resources;Hypertension;Image;Immune;Immunosuppression;Immunosuppressive Agents;improved;in vivo;Incidence;Infection;Inflammatory;inhibitor;Injury;KDR gene;Knock-out;Knockout Mice;limbal;Lymphangiogenesis;Lymphatic;Lymphatic Endothelial Cells;lymphatic vessel;Malignant Neoplasms;Mechanics;Mediator;Membrane;Methods;Military Personnel;Mission;Modeling;Molecular;mouse model;Mus;Neuropilin-1;Neuropilin-2;new growth;Nuclear;ocular surface;ocular surface disease;Organ Transplantation;Pathologic;Penetration;Persons;Pharmaceutical Preparations;Play;Pneumonia;pressure;prevent;Process;receptor;Receptor Cell;Receptor Signaling;Research;response;Role;Secondary to;side effect;Signal Pathway;spatiotemporal;Stem cell transplant;stem cells;Stromal Cells;success;tamoxifen receptor;Testing;Time;Tissues;transcriptome sequencing;transplant model;Transplantation;Trauma;Traumatic injury;Vascular Endothelial Cell;Vascular Endothelial Growth Factor Receptor-1;Vascular Endothelial Growth Factors;Vascularization;VEGFA gene;Veterans;Veterans Health Administration;Visual impairment

PROJECT_TITLE: Modulation of VEGF receptors to prevent limbal stem cell transplant rejection


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Breastfeeding, Lactation and Breast Milk;Endocrine Disruptors;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunization;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention;Vaccine Related;Women's Health Research

ORG_CITY: DURHAM

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Public Health Relevance: Many communities near military and industrial sites have drinking water with high PFAS concentrations, yet the potential health risks associated with these exposures are not well understood. This study will contribute to the understanding of the impact of perinatal PFAS exposure on immune function in early life, specifically, antibody transfer through placenta and milk and immune response to vaccination after birth and the underlying mechanisms. Study findings will not only help address community concerns at Pittsboro, NC where drinking water were heavily contaminated with PFAS, they will have widespread implications on our ability to understand potential effects of elevated PFAS levels on health and inform policy and clinical interventions.

PI_NAMEs: FENG, LIPING  (contact)

PROGRAM_OFFICER_NAME: SCHUG, THADDEUS

PROJECT_TERMS: Address;Animal Model;Animals;Antibodies;Antibody Response;antibody transfer;Antigens;Birth;Blood;Blood specimen;Breast Feeding;Cells;Cellular Immunity;Chemical Exposure;Chemicals;Child;Childhood;Circulation;Cities;Clinical;Communities;consumer product;contaminated drinking water;Data;design;Development;Disease susceptibility;drinking water;EGF gene;Endocrine;Endocrine disruption;Environment;environmental health disparity;epidemiology study;experience;exposed human population;Exposure disparity;Exposure to;Fc Receptor;Female;fetal;Fetal Weight;Fetus;Foundations;Gut associated lymphoid tissue;gut microbiota;Health;hormonal signals;Hormones;Human;Human Milk;Immune;immune function;Immune response;Immune system;Immune System Diseases;Immunoglobulin A;Immunoglobulin G;Immunosuppression;immunotoxicity;in utero;indexing;Individual;Industrialization;insight;Interruption;Intervention;Lactation;Life;Mammary Duct;Mammary gland;mammary gland development;Maternal Exposure;Measures;Metagenomics;Military Personnel;Milk;Modeling;Morphology;neonatal Fc receptor;North Carolina;novel;offspring;Oryctolagus cuniculus;Outcome;Oxytocin;Perinatal;Peripheral Blood Mononuclear Cell;Placenta;placental transfer;Play;Policies;Poly-fluoroalkyl substances;Population;postnatal;Predisposition;Pregnancy;Progesterone;Prolactin;public health relevance;receptor;Recommendation;Regulation;reproductive toxicity;Research;Risk;Rodent;Role;Route;Signal Transduction;single cell sequencing;Site;Somatotropin;Source;Spleen;Sulfonic Acids;Syncytiotrophoblast;System;Systems Development;Testing;Tissues;Toxic effect;Toxicology;Vaccinated;Vaccination;vaccine immunogenicity;Vaccines;Weight

PROJECT_TITLE: Perinatal Per- and Polyfluoroalkyl Substances (PFAS) exposure and Immunotoxicity in early life

STUDY_SECTION: SIEE

STUDY_SECTION_NAME: Systemic Injury by Environmental Exposure[SIEE]


ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

PHR: The potent survival effects of the GFL family of growth factors have led to their development as therapeutic agents for the treatment of diseases and injuries of the nervous system. Likewise, small molecule inhibitors of p75 are currently being developed for the treatment of neurodegenerative disorders. Therefore, and understanding of the mechanisms of action of the GFLs and p75 will aid in the further development and refinement of treatment regimens based on the use of GFLs and p75 inhibitors.

PI_NAMEs: PIERCHALA, BRIAN ANTHONY (contact)

PROGRAM_OFFICER_NAME: TYLER, WILLIAM A

PROJECT_TERMS: Acceleration;Adult;Afferent Neurons;Alzheimer's Disease;Amyotrophic Lateral Sclerosis;Apoptosis;Apoptotic;Automobile Driving;axon guidance;Brain-Derived Neurotrophic Factor;CASP8 gene;CASP9 gene;Caspase;Cell Death;Cell Death Inhibition;Cell surface;Cells;Cessation of life;Complex;deprivation;Development;Disease;experimental study;Family;gamma secretase;GDNF receptors;glial cell-line derived neurotrophic factor;Grant;Growth;Growth Factor;Huntington Disease;In Vitro;in vivo;Induction of Apoptosis;Inhibition of Apoptosis;inhibitor;Ligands;Link;Lysosomes;Mediating;Mediator;member;Membrane Microdomains;Molecular;Motor Neurons;mouse genetics;Mus;Nerve Degeneration;Nerve Growth Factors;nerve supply;Nervous System;Nervous System Trauma;Neurodegenerative Disorders;neurogenesis;Neuroglia;Neurons;Neuropilin-1;neurotrophic factor;Neurotrophic Tyrosine Kinase Receptor Type 1;Nociceptors;Pathogenesis;Pathway interactions;Play;Process;Protein Tyrosine Kinase;Proteolysis;proto-oncogene protein c-ret;receptor;Receptor Activation;Receptor Signaling;Recycling;Regulation;release factor;Role;Semaphorin-3A;Signal Transduction;small molecule inhibitor;somatosensory;Spinal;Structure of superior cervical ganglion;Synapses;Testing;Therapeutic Agents;TNF gene;transcriptional coactivator p75;Treatment Protocols;Withdrawal

PROJECT_TITLE: A p75/Ret Receptor Complex as an Integrator of Survival and Death

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD]


ORG_CITY: CHAPEL HILL

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: PROJECT NARRATIVE A vast amount of biology occurs at interfaces formed by cellular membranes. However, due to the complex and dynamic composition of cellular membranes as well as their inherent capacity to change shape, it has been difficult to study how these interfaces regulate cellular processes. We will use a battery of complementary, biophysical approaches combined with cellular imaging and computational models to manipulate and understand conserved signaling nodes operating at membranes and orchestrated by PLC- isozymes to draw general conclusions applicable to diverse cellular processes occurring at biological membranes.

PI_NAMEs: SONDEK, JOHN E (contact)

PROGRAM_OFFICER_NAME: LEWIS, MECHELLE MAYLEBEN

PROJECT_TERMS: Biochemical;Biological;Biological Process;Biology;biophysical techniques;Biophysics;Cell Physiology;cell type;Cells;cellular imaging;Cellular Membrane;Chemicals;collaborative approach;Complex;Computer Models;Data;Engineering;Feedback;Goals;Image;Immunologic Receptors;insight;interdisciplinary approach;Isoenzymes;Kinetics;Learning;Life;Light;Lipid Bilayers;Membrane;Membrane Lipids;Output;Phospholipase C;phospholipase C gamma;Property;protein purification;receptor;Receptor Protein-Tyrosine Kinases;reconstitution;Regulation;response;Role;self assembly;Shapes;Signal Transduction;Surface;Tissues;transmission process

PROJECT_TITLE: Phospholipase C Isozymes

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


ORG_CITY: NEW YORK

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: Since mitochondria are essential organelles that provide energy to cell and coordinate general metabolism, inherited or acquired defects in mitochondrial functions cause severe diseases often affecting the brain and causing premature death (mitochondrial encephalopathies). The overall mission of this proposal is to improve our understanding of mitochondrial encephalopathies by identifying and harnessing new mechanisms, such as cellular stress responses, that can be used to control the pathological events that occur in affected cells.

PI_NAMEs: MANFREDI, GIOVANNI  (contact)

PROGRAM_OFFICER_NAME: MORRIS, JILL A

PROJECT_TERMS: Address;Affect;age related neurodegeneration;Alzheimer's Disease;Anabolism;biological adaptation to stress;Brain;Catabolism;cell type;Cells;Cellular biology;Cellular Metabolic Process;Cellular Stress;Central Nervous System Diseases;Cessation of life;Characteristics;Defect;Development;Disease;disease model;effective therapy;Encephalopathies;Event;Failure;Generations;Genetic;Genetic Transcription;Heart;Human;human disease;improved;Inherited;innovative technologies;Knowledge;Metabolic;Metabolic Pathway;Metabolism;Mission;Mitochondria;Mitochondrial Diseases;mitochondrial dysfunction;mitochondrial genome;Muscle;Mutation;Nerve Degeneration;Nervous System Disorder;Neuroglia;Neurons;Nuclear;Organelles;Parkinson Disease;Pathogenesis;Pathogenicity;Pathologic;Peripheral;Play;premature;Proteins;Proteome;Research;response;Role;Series;Signal Pathway;Stress;targeted treatment;Therapeutic;Tissues;virtual

PROJECT_TITLE: Mitochondrial Integrated Stress Response in Neurological Diseases


NIH_SPENDING_CATS: Aging;Neurodegenerative;Neurosciences

ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: PROJECT NARRATIVE The nervous system depends on long projections called axons that connect nerve cells across the human body. This project will identify mechanisms used within axon segments to prolong survival and boost resilience against proteotoxic stressors. Insight from this project will identify new avenues for protecting axon function and improving clinical outcome in disease.

PI_NAMEs: SUMMERS, DANIEL  (contact)

PROGRAM_OFFICER_NAME: RANGANATHAN, SRIKANTH

PROJECT_TERMS: 3' Untranslated Regions;Address;Affect;Age;Aging;aging brain;Alzheimer's Disease;Anabolism;Attention;Axon;axon injury;axon regeneration;axonal degeneration;Biology;Brain;cancer cell;Cell Death;Cells;Clinical;Consumption;Cytoplasm;cytotoxic;Defect;Degradation Pathway;Disease;Environment;Enzymes;Event;Failure;Goals;Growth;Health;Hippocampus;Human;Human body;improved;Injury;insight;Knowledge;Length;Maintenance;Messenger RNA;Metabolism;meter;misfolded protein;Molecular Chaperones;Molecular Conformation;Nerve Degeneration;Nervous System;neural circuit;Neurodegenerative Disorders;neuron loss;neuronal cell body;neuronal circuitry;Neurons;neuroprotection;Niacinamide;non-Native;Outcome;Parkinson Disease;Pathway interactions;Peripheral Nervous System Diseases;polypeptide;Predisposition;preservation;Process;protein aggregation;Protein Biosynthesis;protein degradation;protein folding;protein misfolding;Proteins;Proteome;proteostasis;proteotoxicity;Quality of life;Reagent;resilience;response to injury;Ribosomes;Role;Slice;stressor;Synapses;synaptic function;Therapeutic;Transcript;Translations;Work

PROJECT_TITLE: Defining proteostasis networks in axon segments

STUDY_SECTION: NDPR

STUDY_SECTION_NAME: Neurodifferentiation, Plasticity, Regeneration and Rhythmicity Study Section[NDPR]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Hematology

ORG_CITY: NEW ORLEANS

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: XAVIER UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: PROJECT NARRATIVE Venous thromboembolism is a major public health crisis. It annually affects ~1 million people and is responsible for >100,000 annual deaths in the US. Patients may develop recurrent disease and suffer debilitating long-term morbidity. Its economic impact is estimated to be as high as $69 billion per year in the US. Available anticoagulants are associated with a significant risk of bleeding which limits their clinical use. The goal is to develop safer anticoagulants by inhibiting human FXIIIa to effectively prevent/treat the disease.

PI_NAMEs: AL-HORANI, RAMI A (contact)

PROGRAM_OFFICER_NAME: PEI, WUHONG

PROJECT_TERMS: Active Sites;Affect;African American population;Alkanesulfonates;Allosteric Site;Animal Model;Anions;Anticoagulants;Antiplasmin;Area;Binding;Binding Sites;Biochemical;Biological;Biological Assay;Blood;Blood coagulation;Blood Coagulation Factor;Body Weight decreased;Cardiovascular Diseases;Cell Line;Cessation of life;chemical synthesis;Clinical;clinically relevant;Coagulation Process;Contracts;crosslink;Data Reporting;Deposition;design;Disease;economic impact;Economics;effective therapy;Erythrocytes;Evaluation;Exhibits;experimental study;Factor Xa;Factor XIIIa;Fibrin;Fibrinogen;Fibrinolysis;Future;Genetic Polymorphism;Glutaminase;Glycosaminoglycans;Goals;Hemorrhage;Hemostatic function;Heterozygote;Human;improved;In Vitro;inhibitor;innovation;interdisciplinary approach;Investigation;Lead;Libraries;Mediating;Meta-Analysis;mimetics;Minority;molecular modeling;Morbidity - disease rate;mouse model;Mus;Mutation;Naphthalene;Nature;new technology;new therapeutic target;NOR Mouse;Normal Range;novel strategies;Pathologic;Pathology;Patients;Peptide Hydrolases;Persons;pharmacologic;Pharmacologic Substance;Phenocopy;Physiology;Plasmin;polymerization;Polymers;Prevalence;prevent;Prevention;Property;Public Health;Recurrence;Recurrent disease;Regulation;Research;Risk;Role;Route;Serine Protease;Specificity;Structure;Therapeutic;therapeutic target;Thrombin;Thrombus;tool;Transglutaminases;Venous;venous thromboembolism;Wild Type Mouse

PROJECT_TITLE: Inhibitors of Human Factor XIIIa as New Anticoagulants


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Lung;Lung Cancer;Precision Medicine;Prevention;Radiation Oncology

ORG_CITY: STANFORD

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE PIs: Maximilian Diehn, M.D./Ph.D. & Ash Alizadeh, M.D./Ph.D. In this study we will develop and apply novel biomarkers for predicting outcomes of patients with non-small cell lung cancer treated with radiotherapy. Our long-term objective is to personalize treatment of patients treated with radiotherapy by using such biomarkers in order to maximize cure rates and minimize side effects.

PI_NAMEs: ALIZADEH, ASH ARASH;DIEHN, MAXIMILIAN  (contact)

PROGRAM_OFFICER_NAME: PRASANNA, PAT G

PROJECT_TERMS: Area;Biological Markers;Blood;Blood specimen;Cancer Etiology;cancer imaging;Cancer Patient;Cancer Personalized Profiling by Deep Sequencing;Cells;Cessation of life;chemoradiation;Clinical;clinical risk;Clinical Trials;cohort;Data;detection method;Development;Disease;DNA analysis;Doctor of Medicine;Doctor of Philosophy;Early Intervention;experimental study;Foundations;Future;Gene Expression;Genetic Fingerprintings;genetic profiling;Genomics;Genotype;Goals;high risk;Immunotherapy;improved;in vivo;indexing;innovation;liquid biopsy;Local Therapy;Malignant neoplasm of lung;Malignant Neoplasms;Measures;Methods;Modeling;Molecular;molecular marker;Monitor;mouse model;Mutation;new technology;Non-Small-Cell Lung Carcinoma;novel;novel marker;Nucleic Acids;Outcome;outcome prediction;palliative;Patient-Focused Outcomes;Patients;personalized medicine;personalized predictions;Play;Prediction of Response to Therapy;predictive modeling;predictive tools;prevent;Prognostic Factor;prospective;Pulmonary Inflammation;radiation delivery;Radiation Oncology;Radiation Pneumonitis;radiation resistance;Radiation therapy;Recurrence;Residual Neoplasm;Risk;Risk Factors;risk prediction;Risk Reduction;RNA;RNA analysis;Role;side effect;Symptoms;Techniques;Testing;Tissues;tool;Toxic effect;Training;Treatment Failure;Treatment outcome;Treatment-related toxicity;trial design;tumor;tumor DNA;United States;Work

PROJECT_TITLE: Molecularly-based outcome and toxicity prediction after radiotherapy for lung cancer

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


NIH_SPENDING_CATS: Atherosclerosis;Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Diabetes;Disability Research;Health Services;Heart Disease;Heart Disease - Coronary Heart Disease;Patient Safety;Women's Health Research

ORG_DEPT: SURGERY

PHR: PROJECT NARRATIVE The primary objective of this study is to define the long-term impact of coronary artery bypass graft surgery with venous grafts or all-arterial grafts on health-related quality of life and symptom burden among men and women and patients with diabetes and without. The results of this study will build the evidence about the risks and benefits of coronary artery bypass graft surgery, thus influencing future treatment recommendations and clinical practice guidelines. This will lay the foundation for shared decision-making tools to communicate risks and benefits to patients.

PI_NAMEs: GAUDINO, MARIO FL (contact);MASTERSON CREBER, RUTH MARIE

PROGRAM_OFFICER_NAME: KUNZ, JOHN FREDERIC

PROJECT_TERMS: Address;Affect;American;Ancillary Study;Anxiety;Benefits and Risks;Cardiac;Caring;Cessation of life;Climacteric;Clinical;Clinical Practice Guideline;Clinical Trials;Communication;Coronary Artery Bypass;Coronary heart disease;Coronary Vessels;Country;Decision Making;Diabetes Mellitus;diabetic patient;Diagnosis;Dimensions;Disease;Distress;Enrollment;Event;experience;Fatigue;follow-up;Foundations;Funding;Future;global health;Goals;Health;health assessment;health difference;Health Priorities;health related quality of life;Health Surveys;heart disease risk;high risk;improved;Infection;Information Systems;Infrastructure;instrument;Legal patent;Life Expectancy;Measures;men;Mental Depression;Mental Health;Morbidity - disease rate;mortality;Multicenter Trials;Myocardial Infarction;National Heart, Lung, and Blood Institute;novel;Observational Study;Operative Surgical Procedures;Outcome;Outcome Measure;Outcome Study;Pain interference;painful neuropathy;Parents;Participant;Patient Outcomes Assessments;Patient risk;Patient-Focused Outcomes;Patients;physical conditioning;Physical Function;Population;postoperative recovery;prevent;primary outcome;Procedures;prospective;Quality of life;Questionnaires;Randomized;Recommendation;recruit;Reporting;Representational Oligonucleotide Microarray Analysis;Research;Research Personnel;Research Proposals;Risk;Risk Factors;Saphenous Vein;sex;shared decision making;Site;Sleep disturbances;Specific qualifier value;standard of care;Stroke;Subgroup;Surgical complication;surgical risk;Surveys;Symptom Burden;Symptoms;Techniques;Testing;Time;tool;treatment response;trial comparing;United States National Institutes of Health;Vein graft;Venous;Woman;women versus men;Women's cohort;wound healing

PROJECT_TITLE: Randomized comparison of the clinical Outcome of single versus Multiple Arterial grafts: Quality of Life (ROMA:QOL)

STUDY_SECTION: NRCS

STUDY_SECTION_NAME: Nursing and Related Clinical Sciences Study Section[NRCS]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Precision Medicine

PHR: Project Narrative Understanding the genetic basis of common diseases, such as cancers, heart disease, or even response to vaccinations, is essential to realize the broad benefits of personalized medicine. Despite rapid progress in genomic technologies, there are many gaps in how different types of genomic and phenotype data are integrated and analyzed to gain knowledge. The goals of this Maximizing Investigators Research Award are to develop novel statistical and computational methods to integrate different types of data, provide useful software tools to the scientific community, and apply new methods to existing data sets to better understand the genetic basis of human diseases and traits and predict disease risk.

PI_NAMEs: SCHAID, DANIEL J. (contact)

PROGRAM_OFFICER_NAME: MASKERI, BAISHALI

PROJECT_TERMS: analytical method;Area;Award;Biological;Biological Process;Chromosome Mapping;Clinical;Clinical Investigator;Collaborations;Communities;Complex;Computer software;Computing Methodologies;Data;data integration;Data Set;Development;Disease;disorder risk;Disparate;Epidemiologist;Ethnic Population;Etiology;experience;Genetic;genetic epidemiology;genetic variant;genomic data;Genomics;Goals;health data;Heart Diseases;Human;human disease;improved;insight;Knowledge;Malignant Neoplasms;Maps;Mediation;Methods;Molecular;Multivariate Analysis;novel;personalized medicine;phenotypic data;pleiotropism;polygenic risk score;Public Health;Reduce health disparities;Research;Research Personnel;Resources;response;Science;Software Tools;Source;Statistical Methods;Technology;trait;user friendly software;Vaccination;Vision

PROJECT_TITLE: Quantitative Methods for Genetic Epidemiology

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-S(55)R]