ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

ORG_CITY: Princeton

ORG_NAME: PRINCETON UNIVERSITY

PHR: Project Narrative Understanding genome-wide patterns of genetic variation among individuals and how this relates to complex diseases is one of the primary goals of modern medical research. The proposed research will contribute to this goal by tackling a number of open problems in such a way that a coherent statistical framework and set of methodologies will emerge that can be applied to data sets of genome-wide genetic variation to produce a clearer picture of the genetic basis of human disease.

PI_NAMEs: STOREY, JOHN D (contact)

PROGRAM_OFFICER_NAME: ZHANG, LI

PROJECT_TERMS: Admixture;Bioinformatics;Biology;Biomedical Research;Complex;Computer software;Data Set;Disease;flexibility;Gene Frequency;Genetic;genetic association;Genetic Drift;Genetic Variation;genome wide association study;genome-wide;Genomics;Genotype;Goals;Grant;Health;Heritability;Human;human disease;identity by descent;improved;Individual;Linkage Disequilibrium;Measures;Medical Research;member;Methodology;Methods;Modeling;Modernization;Pattern;Performance;polygenic risk score;Polygenic Traits;Population;Population Genetics;Programming Languages;R programming language;Recording of previous events;Research;Research Design;Role;Sample Size;semiparametric;Source Code;Statistical Methods;Statistical Models;Structure;Testing;theories;trait;Update;web site;Writing

PROJECT_TITLE: Models and Methods for Population Genomics

STUDY_SECTION: BMRD

STUDY_SECTION_NAME: Biostatistical Methods and Research Design Study Section[BMRD]


ADMINISTERING_IC: DA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cannabinoid Research;Drug Abuse (NIDA only);Endocannabinoid System Research;Genetics;HIV/AIDS;Infectious Diseases;Neurodegenerative;Neurosciences;Nutrition;Substance Misuse

ORG_CITY: CHAPEL HILL

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PSYCHOLOGY

ORG_FIPS: US

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative Cannabis use is known to alleviate common symptoms and complications in PWH on cART but its effect on neurocognition is not clear. With the use of in vivo calcium imaging the goal of the proposed study is to determine cannabis-induced changes on neuronal activity in a neuroHIV mouse model during performance of a behavioral appetitive learning task and its relation to the endocannabinoid system. This work will advance the understanding of cannabis use in the context of neuroHIV and may lead to new cannabinoid therapeutic strategies for recovery.

PI_NAMEs: FITTING, SYLVIA  (contact)

PROGRAM_OFFICER_NAME: VEMURI, KIRAN R V

PROJECT_TERMS: 2-arachidonylglycerol;Adult;Age Months;Animal Testing;Animals;antiretroviral therapy;Anxiety;Association Learning;Astrocytes;Behavior;Behavior assessment;behavior test;Behavioral;Brain;Brain region;Calcium;cannabinoid treatment;Cannabinoids;Cannabis;Cells;Chronic;chronic pain;CNR1 gene;CNR2 gene;cognitive function;cognitive performance;cohort;common symptom;Communication;Conditioned Stimulus;Cues;Desire for food;Discrimination Learning;Disease;Dose;Drug usage;Endocannabinoids;endogenous cannabinoid system;Enzymes;excitotoxicity;Experimental Designs;Exposure to;Female;Genetic Transcription;Genotype;Goals;GPR55 receptor;Head;HIV;HIV-1;HIV-associated neurocognitive disorder;Human;humanized mouse;Immunohistochemistry;Impaired cognition;in vivo;in vivo calcium imaging;Induced Neurons;Inflammation;Inflammatory;Injections;innovation;Learning;Ligands;Liquid Chromatography;male;marijuana use;Memory;Mental Depression;Microglia;mouse model;Mouse Protein;Mus;Nausea;Nerve Degeneration;neuroAIDS;Neurocognition;neurocognitive disorder;neuroinflammation;Neuronal Dysfunction;neuronal excitability;Neurons;neuropathology;novel;Nucleus Accumbens;Outcome;Pathology;Performance;Persons;Pharmaceutical Preparations;Pisum sativum;Play;preclinical study;Prefrontal Cortex;Prevalence;Process;Proteins;receptor;Recovery;Reporting;response;Rewards;Role;success;Sucrose;Symptoms;Synapses;System;tandem mass spectrometry;THC exposure;Therapeutic;Training;Trans-Activators;Transcription Coactivator;Transcriptional Regulation;Transgenic Mice;Transgenic Organisms;Viral;Virus Diseases;Visualization;Work

PROJECT_TITLE: In vivo calcium imaging during appetitive learning in HIV Tat transgenic mice exposed to cannabis

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


ADMINISTERING_IC: EB

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_CITY: Chicago

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE/PUBLIC HEALTH RELEVANCE STATEMENT The development of effective strategies to deliver therapeutic macromolecules will benefit from biologically inspired solutions already employed by cells to achieve this goal. This proposal aims to define matrimeres as a novel class of cell-secreted nanoparticles that deliver extracellular matrix molecules to the host after tissue injury and treat vascular leakage. Success of the proposed studies will inform new nanomedicine that can be leveraged to promote regeneration of vascularized tissues.

PI_NAMEs: SHIN, JAE-WON  (contact)

PROGRAM_OFFICER_NAME: CHEN, JERMONT

PROJECT_TERMS: Address;Adherens Junction;Affinity;Agonist;Autophagocytosis;Autophagosome;Biocompatible Materials;Biodistribution;Biogenesis;Bioinformatics;Biology;Blood Vessels;cadherin 5;Cell Communication;Cell secretion;Cells;Cellular biology;Chemicals;Chromatin;Complex;Data;Deoxyribonuclease I;design;Development;Disease;DNA;Edema;Elastic Tissue;Elasticity;Endothelial Cells;Endothelium;Endotoxemia;Engineering;Environment;Extracellular Matrix;Extracellular Matrix Proteins;extracellular vesicles;Extravasation;Failure;Fibronectins;Fibrosis;Genetic;Genomic DNA;Goals;Guanine + Cytosine Composition;Histones;Hydrogels;Image;improved;in vivo;Inflammatory;injured;Injury;insight;Integrins;interdisciplinary approach;Length;Lipopolysaccharides;Lung;lung injury;Lysosomes;macromolecule;Mediating;Mediator;member;mesenchymal stromal cell;Molecular Biology;Molecular Conformation;Monomeric GTP-Binding Proteins;multidisciplinary;Mus;nanomedicine;nanoparticle;nanoparticle delivery;nanoscale;Nanostructures;Nanotechnology;Natural regeneration;novel;Organ;Outcome;paracrine;Paracrine Communication;Pathway interactions;Permeability;pharmacologic;Physiological;Play;prevent;Process;Production;Property;Proteins;PTK2 gene;public health relevance;reconstitution;Recycling;regenerative;Research Personnel;Reverse engineering;RGD (sequence);Role;Route;Signal Pathway;Signal Transduction;Sonication;Structure of parenchyma of lung;success;synthetic construct;synthetic peptide;Testing;Therapeutic;tissue injury;Tissues;Trauma;Vascular Permeabilities;Vascularization;Work

PROJECT_TITLE: Therapeutic nanoscale matrimeres

STUDY_SECTION: NANO

STUDY_SECTION_NAME: Nanotechnology Study Section[NANO]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Pediatric;Suicide

ORG_CITY: PROVIDENCE

ORG_DEPT: PSYCHIATRY

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: Project Narrative This project is designed to study suicidal thoughts and behavior in a sample of young children, 8 to 11 years old, who are being treated for emotional and behavioral difficulties. The goal of the study is to better understand suicidal thoughts and behavior in preteen children. Specifically, if these thoughts and behaviors lead to future suicidal thoughts and behavior and psychiatric care over a 12-month follow-up period.

PI_NAMEs: SPIRITO, ANTHONY  (contact);WOLFF, JENNIFER CHRISTINE

PROGRAM_OFFICER_NAME: GARVEY, MARJORIE ANN

PROJECT_TERMS: 11 year old;17 year old;Address;Admission activity;adolescent patient;Affect;Age;age group;Assessment tool;associated symptom;Behavior;Behavior assessment;Behavioral;behavioral outcome;Biological Markers;Caring;Cessation of life;Child;child depression;Clinical;Clinical assessments;clinical practice;cognitive capacity;Consensus;critical period;Data;Day Care;design;Development;Discipline of Nursing;emotion regulation;Emotional;Ensure;experience;Failure;Feedback;Feeling suicidal;field study;follow-up;Future;gender minority youth;Goals;Health Services Research;high risk population;Hospitalization;Hospitals;ideation;Implicit Association Test;improved;improved outcome;informant;innovation;Inpatients;interest;Intervention Studies;Interview;Lead;Measures;medical schools;Mental disorders;Methods;Minority;multimodality;National Institute of Mental Health;Onset of illness;Parents;Patient Self-Report;Patients;Population Heterogeneity;preadolescence;protective factors;Psychiatric therapeutic procedure;Psychiatrist;Psychologist;Psychopathology;Random Allocation;Recommendation;recruit;Research;Research Domain Criteria;Research Personnel;resilience;response;Risk;Risk Factors;Safety;Sampling;Self-Injurious Behavior;Series;Services;Sexual and Gender Minorities;sexual minority youth;Structure;suicidal;suicidal adolescent;suicidal behavior;Suicide;Suicide attempt;suicide rate;symptomatology;Symptoms;Teenagers;Testing;theories;Thinking;Time;Work;Youth

PROJECT_TITLE: Towards a reliable and valid assessment of preteen suicidal thoughts and behavior

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


NIH_SPENDING_CATS: Biotechnology;Drug Abuse (NIDA only);HIV/AIDS;Immunization;Infectious Diseases;Prevention;Substance Misuse;Vaccine Related

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE The high level of HIV variability and the polymorphic nature of MHC-Ia alleles are major challenges to the development of a broadly effective CTL-based vaccine. This proposal aims to overcome these obstacles by leveraging the conserved MHC-1b allele HLA-E and mutation-resistant HLA-E-restricted CTL epitopes in a rationally designed, therapeutic CTL-based vaccine for HIV. Thus, the proposed work is relevant to the NIH’s mission to seek and apply knowledge to lengthen life and reduce illness.

PI_NAMEs: GAIHA, GAURAV DAS (contact)

PROGRAM_OFFICER_NAME: BORGMANN, KATHLEEN RUTH

PROJECT_TERMS: Adherence;Alleles;Animals;Antigens;Award;Cytotoxic T-Lymphocytes;Data;Development;Doctor of Medicine;drug of abuse;Epidemic;Epitopes;General Hospitals;Genes;HIV;HIV vaccine;Human;immunogenicity;Individual;innovation;Knock-in;Knowledge;Life;Massachusetts;medical schools;Medicine;Methodology;Mission;Mus;National Institute of Drug Abuse;Nature;novel;novel vaccines;Pathway Analysis;Population;professor;protein structure;Proteome;rational design;Research;resistance mutation;Structure;T cell response;T-Lymphocyte Epitopes;Testing;theories;Therapeutic;Translations;United States National Institutes of Health;Vaccination;vaccine candidate;Vaccines;Work

PROJECT_TITLE: Harnessing Highly Networked HLA-E-Restricted CTL Epitopes to Achieve a Broadly Effective HIV Cure


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Dental, Oral, and Craniofacial Disease;Health Services;Patient Safety;Prevention;Primary Health Care

ORG_CITY: INDIANAPOLIS

ORG_DEPT: DENTISTRY

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Project Narrative This application aims to develop and evaluate a usable patient medical summary (PMS) imported from the state-wide community Indiana Health Information Exchange (IHIE) that updates a dental clinician about their patients’ medical history and can be used even in solo- and small-group dental practice settings. The two primary outcomes are reducing dental clinicians’ (DCs) reliance on patients and physicians’ office for information that delays treatment and reducing patients’ burden to share information with DCs. The proposed study will lay the foundation for bidirectional communication between dental and medical professionals that enhances dental and overall care among the US population, promotes preventive management, and reduces dental care costs.

PI_NAMEs: THYVALIKAKATH, THANKAM P (contact)

PROGRAM_OFFICER_NAME: GRISIUS, MARGARET

PROJECT_TERMS: Address;Adverse event;Affect;Architecture;care coordination;care costs;care delivery;Caring;Chronic Disease;Clinical;Communication;Communities;Community Health;Consult;COVID-19 pandemic;Dental;Dental Care;Dental General Practice;Dental Group Practice;Dental Hygienists;Dental Records;Dental Schools;Dentistry;Dentists;design;Development;Disease;disease transmission;effectiveness evaluation;Electronic Health Record;Electronics;Evaluation;Fast Healthcare Interoperability Resources;Focus Groups;Foundations;Goals;Health;health care delivery;health care service organization;health management;improved;Indiana;informant;information organization;innovation;integrated care;Interview;Medical;Medical History;Medicine;Methods;new technology;Oral;Oral health;Outcome;Patient Care;patient population;patient safety;Patients;Pharmaceutical Preparations;Physicians;Physicians' Offices;Population;population health;practice setting;prevent;Preventive;primary outcome;Protocols documentation;prototype;Provider;provider communication;Questionnaires;Recording of previous events;Reporting;Research Design;response;Risk;Scanning;screening;Service delivery model;Specialist;Study Subject;success;System;technology development;Time;Update;usability;user centered design;Vaccination;Vendor

PROJECT_TITLE: Development and evaluation of patient medical summary from health information exchange to improve dental care

STUDY_SECTION: CIDH

STUDY_SECTION_NAME: Clinical Informatics and Digital Health Study Section[CIDH]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Breast Cancer;Cancer;Nanotechnology;Women's Health Research

ORG_CITY: MORGANTOWN

ORG_NAME: WEST VIRGINIA UNIVERSITY

ORG_STATE: WV

PHR: PROJECT NARRATIVE Magnetic resonance imaging (MRI) is one of the most powerful diagnostic tools available in clinics. However, the recent rising concern about the toxicity of gadolinium-based contrast agents has lead to renewed interest in finding alternatives. This project proposes to develop a new class of metal-free MRI contrast agents based on biocompatible and biostable organic triarylmethyl radicals.

PI_NAMEs: DRIESSCHAERT, BENOIT  (contact)

PROGRAM_OFFICER_NAME: ATANASIJEVIC, TATJANA

PROJECT_TERMS: Acute Renal Failure with Renal Papillary Necrosis;Animal Cancer Model;Binding;biomaterial compatibility;biomedical imaging;Blood - brain barrier anatomy;bone;Brain;Breast Cancer Model;cancer imaging;Cancer Model;chelation;Chemistry;Chronic Kidney Failure;Circulation;Clinic;Communities;Compensation;contrast enhanced;Contrast Media;Dendrimers;Deposition;design;Development;Diagnostic;diagnostic tool;diagnostic value;Disease;Dose;Drug Kinetics;Excretory function;experience;Fibrosis;Fluorescence;Fluorescent Dyes;Future;Gadolinium;Generations;hazard;Hepatobiliary;High Risk Woman;hydrophilicity;Hydroxylamine;Image;imaging capabilities;imaging modality;Impairment;improved;In Vitro;in vivo;in vivo imaging;Injections;interest;iron oxide nanoparticle;Kidney;Lead;Life;Ligands;Liquid substance;Magnetic Resonance Imaging;Malignant Breast Neoplasm;Manganese;Medical;Metabolism;Metals;Modeling;Modification;mouse model;MRI Scans;Names;near infrared dye;Nephrogenic Systemic Fibrosis;next generation;nitroxyl;optical imaging;organic base;Patient Agents;Patients;Peptides;Performance;Pharmacologic Substance;Phase;Physicians;Polymers;Pre-Clinical Model;Prognosis;Property;Protocols documentation;radiologist;Recommendation;Renal function;Reporting;Risk;Safety;scaffold;Scientist;Shapes;Skin;Solid;superparamagnetism;Surface;theranostics;Therapeutic Agents;Tissues;Toxic effect;Toxicology;tumor;Tumor-associated macrophages;Validation;virtual;Work

PROJECT_TITLE: Biocompatible triarylmethyl radical-based dendrimers as nonmetallic contrast agents for MRI


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Neurodegenerative;Neurosciences;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Krabbe is a deadly brain disease of infancy that has no cure. In this proposal, we aim to discover how microglia, the resident immune cells of the brain, contribute to this disease, and how they can be used to treat it more effectively.

PI_NAMEs: BENNETT, FREDERICK  (contact)

PROGRAM_OFFICER_NAME: MORRIS, JILL A

PROJECT_TERMS: Adopted;Appearance;Astrocytes;Birth;Brain;brain cell;Brain Diseases;brain tissue;Cell Therapy;Cells;cellular engineering;Central Nervous System;Childhood;CSF1R gene;Data;Disease;disorder risk;Donor person;Effectiveness;Embryo;Engineering;Engraftment;Future;Genetic;Globoid cell leukodystrophy;Hematopoietic Stem Cell Transplantation;Heterogeneity;Immune;improved;infancy;Infiltration;inhibitor;Injections;innovation;Knowledge;Label;leukodystrophy;Ligands;Lysosomal Storage Diseases;Macrophage;Maps;Methods;Microglia;Modeling;Mus;Mutation;myelination;Names;Nervous System Disorder;nervous system transplantation;Neurodegenerative Disorders;neuropathology;new therapeutic target;novel strategies;Pathogenesis;Pathogenicity;Pathologic;Pathology;Pathway interactions;Peripheral;Population;preconditioning;receptor;reconstitution;Regulation;Resistance;risk variant;Role;single cell sequencing;small molecule inhibitor;Synapses;targeted treatment;Testing;Therapeutic;Tissues;tool;transcriptomics;translational potential;Transplantation;transplantation therapy;Treatment Efficacy;unpublished works;Variant;Work

PROJECT_TITLE: Role of Brain Macrophages in the Pathogenesis and Treatment of Globoid Cell Leukodystrophy


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_DEPT: ORTHOPEDICS

PHR: NARRATIVE If successful, this proposal will significantly advance our understanding of how hypoxia, hypoxia-driven pathways, and bioenergetic metabolism control somitogenesis. The successful accomplishment of the experimental plan described in this proposal may identify the transcription factors HIF-1alpha and HIF2-alpha as novel regulators of somitogenesis. This knowledge could provide novels insights into the pathogenetic mechanisms underlying both Spondylocostal Dysostosis and Congenital Scoliosis due to gestational hypoxia.

PI_NAMEs: SCHIPANI, ERNESTINA  (contact)

PROGRAM_OFFICER_NAME: MUKHOPADHYAY, MAHUA

PROJECT_TERMS: Address;angiogenesis;Biochemical Reaction;Bioenergetics;Cardiovascular system;Cells;Compensation;Congenital Abnormality;Congenital Scoliosis;Connective Tissue;Consumption;Data;Defect;Development;Dysostoses;Embryo;Embryonic Development;Epigenetic Process;experience;experimental study;Exposure to;Genetic;Genetic Transcription;gestational hypoxia;Heterozygote;HIF1A gene;Human;human disease;Hypoxia;Hypoxia Inducible Factor;Impairment;in vivo;insight;Knowledge;loss of function mutation;malformation;Mediating;Mediator;Mesoderm;Metabolism;Mitochondria;Mus;mutant;Mutant Strains Mice;Mutation;notch protein;Notch Signaling Pathway;novel;Oxygen;Pathway interactions;Periodicity;Phenocopy;Phenotype;Positioning Attribute;Pregnancy;Process;Regulation;Respiration;response;Role;Signal Transduction;Site;Somites;somitogenesis;spine bone structure;Testing;Time;tool;transcription factor;transcriptome;Transgenic Mice;Vertebral column

PROJECT_TITLE: Hypoxia and mitochondria in spine development and congenital scoliosis

STUDY_SECTION: SBDD

STUDY_SECTION_NAME: Skeletal Biology Development and Disease Study Section[SBDD]


NIH_SPENDING_CATS: Neurosciences;Pediatric

ORG_CITY: COLD SPRING HARBOR

ORG_NAME: COLD SPRING HARBOR LABORATORY

ORG_STATE: NY

PHR: PROJECT NARRATIVE  Neurodevelopmental disorders such as autism represent a significant and growing healthcare and economic burden to the United States, yet effective pharmacological therapies for these debilitating conditions remain limited. We propose to apply a range of diverse neuroscience approaches to characterize a newly discovered role for a unique class of non-neuronal brain cells, oligodendrocyte precursor cells, in a late stage of postnatal brain development that goes awry in neurodevelopmental disorders. We expect the proposed studies to lay the groundwork for new therapeutic strategies aimed at manipulating oligodendrocyte precursor cell function early in life to correct the neurobiological deficits that underlie neurodevelopmental disorders, thereby ameliorating their symptoms across the lifespan.

PI_NAMEs: CHEADLE, LUCAS M (contact)

PROGRAM_OFFICER_NAME: LEENDERS, MIRIAM

PROJECT_TERMS: Ablation;Age;Animal Behavior;Animals;Astrocytes;autism spectrum disorder;Axon;Behavioral Assay;Biological;Biological Models;Brain;brain cell;Brain Diseases;Cell Physiology;Cells;Child;Complex;CRISPR screen;critical period;Data;Development;Disease;Economic Burden;Excision;experience;experimental study;Eye;Foundations;Future;Goals;Health;healthcare burden;Healthcare Systems;Human;Impairment;in vivo;Individual;insight;interdisciplinary approach;Life;life span;Light;Link;Mediating;Microglia;Modernization;Molecular;Monitor;multidisciplinary;Mus;myelination;Nature;nerve stem cell;neural circuit;Neurobiology;Neurodevelopmental Disorder;Neuroglia;Neurologic;Neurons;Neurophysiology - biologic function;Neurosciences;novel;novel therapeutic intervention;oligodendrocyte progenitor;Oligodendroglia;optogenetics;Pathway interactions;Phagocytes;Phagocytosis;pharmacologic;Phase;Physiological;Play;Population;postnatal;postnatal development;precursor cell;Prevalence;Process;Property;receptor;response;Role;Route;Sensory;Shapes;spatiotemporal;symptomatic improvement;Symptoms;Synapses;targeted treatment;Techniques;Testing;Therapeutic;therapy development;Time;tool;transcriptomics;Transgenic Organisms;treatment strategy;two photon microscopy;United States;Viral Genes;Visual;Visual Cortex;Visual System;Work

PROJECT_TITLE: Synapse Engulfment by Oligodendrocyte Precursor Cells: A New Mechanism of Circuit Refinement in the Developing Brain

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_DEPT: CHEMISTRY

PHR: WONHWA CHO, PH.D. PUBLIC HEALTH RELEVANCE STATEMENT Lipid signaling is an important target for drug development for diverse human diseases, including cancer. Based on our recent research showing that membrane lipids directly and specifically control cellular activities of diverse proteins that are critically involved in cancer, we propose to elucidate the mechanisms underlying complex lipid-mediated cell regulation and develop drugs targeting lipid- protein binding interfaces. Given the general and fundamental importance of lipid signaling, our pioneering, innovative research should have major impact on broad areas of biology and medicine.

PI_NAMEs: CHO, WONHWA  (contact)

PROGRAM_OFFICER_NAME: NIE, ZHONGZHEN

PROJECT_TERMS: Affinity;Area;Binding;Binding Proteins;Biology;cell growth regulation;Cell Physiology;Cells;Cholesterol;Complex;Disease;DLG4 gene;Doctor of Philosophy;drug development;drug discovery;Drug Targeting;Foundations;Health;human disease;Human Genome;Imaging technology;In Situ;innovation;Lipids;Malignant Neoplasms;Mediating;Medicine;Membrane Lipids;Phosphatidylinositols;Physiological;Process;protein complex;protein protein interaction;Proteins;public health relevance;Regulation;Research;Signal Pathway;Signal Transduction;spatiotemporal;Specificity

PROJECT_TITLE: Lipid regulation of cellular signaling and protein-protein interactions

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


NIH_SPENDING_CATS: Autoimmune Disease;Bioengineering;Biomedical Imaging;Brain Disorders;Data Science;Multiple Sclerosis;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences

ORG_CITY: LOS ANGELES

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: Relevance to Public Health This project will develop an open source suite of software for the processing, analysis, and visualization of rodent brain imaging data, which will enhance the ability of neuroscience researchers to perform preclinical studies on rodent models. This software will provide advanced capabilities for analyzing multimodal imaging data, including imagery from magnetic resonance imaging and optical microscopy studies, with the goal of improving understanding of processes and mechanisms underlying neurological diseases and disorders and their potential treatment. The software will include interactive processing to facilitate ease of use, as well as command line tools to enable large scale processing for larger studies.

PI_NAMEs: MACKENZIE-GRAHAM, ALLAN JAMES;SHATTUCK, DAVID W (contact)

PROGRAM_OFFICER_NAME: BABCOCK, DEBRA J

PROJECT_TERMS: Address;Anatomy;Animal Disease Models;animal imaging;Animals;Area;Atlases;automated segmentation;Automobile Driving;Axon;Brain;Brain Diseases;Brain imaging;brain tissue;Cell Count;Classification;Collection;Communities;community engagement;Compensation;Computer software;computerized data processing;Computing Methodologies;Confocal Microscopy;Data;Data Analyses;data integration;Data Set;data visualization;Dedications;deep learning;Dendritic Spines;Development;Diffusion;Diffusion Magnetic Resonance Imaging;Documentation;Drug or chemical Tissue Distribution;Ensure;Evaluation;experience;Experimental Autoimmune Encephalomyelitis;experimental study;Feedback;Functional Magnetic Resonance Imaging;Generations;Goals;graphical user interface;Head;Human;human data;Image;Image Analysis;image processing;Imagery;Imaging Device;imaging modality;imaging study;improved;Informatics;insight;interoperability;Investigation;Label;Licensing;Magnetic Resonance Imaging;Manuals;Maps;Measures;Methods;microscopic imaging;Microscopy;Modality;Modeling;mouse model;multidimensional data;Multimodal Imaging;multimodality;Multiple Sclerosis;Mus;Nerve Degeneration;Nervous System Disorder;Neuroanatomy;neuroimaging;Neurons;Neurosciences;normal aging;novel;open source;open source tool;optical imaging;Optics;Performance;Play;pre-clinical;preclinical study;Process;Public Health;recruit;Reporting;Reproducibility;Research;Research Personnel;Resort;Resources;Rodent;Rodent Model;Role;Scanning;Shapes;software development;Software Tools;Statistical Data Interpretation;statistics;Structural Models;Structure;Techniques;Testing;Tissue Sample;Tissues;tool;tractography;Training;Visualization;Visualization software;web site;Work

PROJECT_TITLE: A Toolkit for Analysis and Visualization of Preclinical Rodent Neuroimaging Experiments

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Climate-Related Exposures and Conditions;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Pediatric;Pediatric Cancer;Precision Medicine;Prevention;Rare Diseases;Skin Cancer

ORG_CITY: SALT LAKE CITY

ORG_DEPT: DERMATOLOGY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE Skin cancer prevention programs should address sun protection and tanning behaviors in young populations, particularly adolescents. A novel skin cancer prevention program that builds on adolescents’ need for personalization and experiential learning will be implemented through high schools. Increases in adolescent use of sun protection and decreases in tanning will help to reduce the incidence of melanoma.

PI_NAMEs: WU, YELENA PING (contact)

PROGRAM_OFFICER_NAME: PERNA, FRANK

PROJECT_TERMS: academic standard;Active Learning;Address;Adolescent;adolescent health;arm;Behavior;cancer education;Caucasians;Cells;Child;Childhood;Cluster randomized trial;Data;Dermatology;design;Diagnosis;Disease;Drug abuse;Education;efficacy evaluation;efficacy testing;elementary school;Environmental Risk Factor;Exposure to;Face;Female;follow-up;Funding;Future;Geography;Goals;Habits;Health;Health behavior change;Health education;high school;improved;Incidence;Individual;interest;Intervention;intervention effect;Intervention Studies;Investigation;Malignant Neoplasms;Measures;Mediating;Mediation;Melanoma;Modeling;monitoring device;multi-component intervention;National Cancer Institute;ninth grade;novel;Outcome;Parents;Patient Self-Report;personalized approach;personalized intervention;personalized learning;Persons;Population;post intervention;Predisposition;prevent;Prevention program;Prevention strategy;Preventive;preventive intervention;primary outcome;Process;programs;Protective Clothing;Quasi-experiment;Questionnaires;Radiation induced damage;randomized trial;recruit;Reporting;Research;Risk;Sampling;Schools;Seasons;secondary outcome;Self Efficacy;sex;Skin;Skin Cancer;skin cancer prevention;Skin tanning;Smoking;Students;Subgroup;sun protection;Sunburn;Sunscreening Agents;teacher;tenth grade;Testing;Time;Treatment Cost;Treatment Efficacy;ultraviolet damage;Ultraviolet Rays;Underserved Population;United States National Institutes of Health;UV Radiation Exposure

PROJECT_TITLE: A personalized approach to skin cancer prevention among adolescents

STUDY_SECTION: CLHP

STUDY_SECTION_NAME: Community-Level Health Promotion Study Section[CLHP]


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Immunotherapy;Women's Health Research

ORG_CITY: BIRMINGHAM

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: The proposal will elucidate how RANKL orchestrates intercellular signaling through canonical and non-canonical signaling, causing myeloid cell immunosuppressive functions in the tumor microenvironment during breast cancer bone metastasis and test targeting of immune resistance and osteoclast activation using a novel OPG and PD-1 antibody ± chemotherapy combination in both pre-metastasis and bone metastasis models in vivo.

PI_NAMEs: PONNAZHAGAN, SELVARANGAN  (contact)

PROGRAM_OFFICER_NAME: HOWCROFT, THOMAS K

PROJECT_TERMS: Address;Adopted;Affinity;antagonist;Antibodies;Apoptosis;Autocrine Communication;Binding;bone;Bone Diseases;Breast Cancer Cell;breast cancer metastasis;Breast Cancer Model;Breast Cancer Risk Factor;CD8-Positive T-Lymphocytes;Cell Physiology;Cell Therapy;Cells;chemotherapy;Clinic;Combination Drug Therapy;Combined Modality Therapy;cytokine;design;Disease;Disease Progression;Double-Blind Method;effector T cell;Engineering;Environment;exhaustion;G-Protein-Coupled Receptors;genetically modified cells;Goals;high risk;Homeostasis;Human;Human Pathology;Immune;immune checkpoint blockade;immune resistance;Immune system;Immune Targeting;Immunocompetent;Immunocompromised Host;Immunosuppression;improved;in vivo;in vivo Model;Induction of Apoptosis;Injections;International;Leucine-Rich Repeat;Ligand Binding;Ligands;Link;Macrophage;Malignant Bone Neoplasm;Malignant Breast Neoplasm;Mediator;Metastatic breast cancer;Metastatic Neoplasm to the Bone;Molecular;Monoclonal Antibodies;Monoclonal Antibody Therapy;monocyte;mouse model;Mus;Myeloid Cells;Myeloid-derived suppressor cells;Neoplasm Metastasis;neoplastic cell;new combination therapies;novel;Nuclear;Osteoclasts;Osteolysis;Outcome Study;paracrine;Pathology;Pathway interactions;Patients;Phase;phase 3 study;Placebo Control;Play;polarized cell;Primary Neoplasm;Production;programmed cell death ligand 1;programmed cell death protein 1;Protein Engineering;protein structure;Proteins;Publishing;Randomized;receptor;receptor function;Recurrent disease;Refractory;Resistance;Role;Signal Transduction;skeletal;Skeletal system;skeletal-related events;spatiotemporal;Structure;Systemic Therapy;targeted treatment;taxane;Testing;Therapeutic;Therapeutic Effect;therapeutic target;TNF-related apoptosis-inducing ligand;TRANCE protein;tumor;tumor growth;tumor microenvironment;Tumor necrosis factor receptor 11b;Tumor Promotion;Variant

PROJECT_TITLE: Mechanisms and therapeutic targeting of osteoimmune functions of RANKL in breast cancer

STUDY_SECTION: DT

STUDY_SECTION_NAME: Developmental Therapeutics Study Section[DT]


ORG_CITY: CAMBRIDGE

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: HARVARD UNIVERSITY

PHR: PROJECT NARRATIVE In a developing embryo, all cells must acquire appropriate fates, including germ cells, which make eggs and sperm and are thus absolutely required for reproduction and species survival. This proposal will uncover the mechanisms that ensure that germ cells acquire their fates correctly by virtue of special cytoplasmic aggregates, which are similar to aggregates that regulate other types of cell fates in many somatic cells. Thus, the experiments proposed here will shed light both on how cells like germ cells are normally specified, and on why mutations in the genes encoding the molecular components of the cytoplasmic aggregates can lead to human disease.

PI_NAMEs: EXTAVOUR, CASSANDRA G (contact)

PROGRAM_OFFICER_NAME: WELLS, MELISSA LYNN

PROJECT_TERMS: Adopted;Affect;Affinity;Animals;Binding;Biochemical;Bioinformatics;Biological Assay;Biological Process;biophysical properties;cell fate specification;cell type;Cells;Cytoplasm;Data;Defect;Development;Developmental Biology;Dimerization;Drosophila genus;egg;Embryo;Embryonic Development;Ensure;experimental study;Failure;Gel;Genes;Genetic;Germ;Germ cell tumor;Germ Cells;Germ Lines;Goals;gonadal cancer;Growth;Health;Human;human disease;In Vitro;in vivo;Individual;Infertility;Inherited;innovation;Light;Lipid Binding;Lipids;Liposomes;Malignant neoplasm of ovary;Mediating;Membrane;Messenger RNA;Mitochondria;Modification;Molecular;Molecular Biology;Mutagenesis;Mutation;N-terminal;novel;novel strategies;Oocytes;Oogenesis;Organelles;Organism;Pathology;Phase;Population;Property;protein aggregation;Protein Isoforms;protein protein interaction;Proteins;Recording of previous events;recruit;Reproduction;reproductive;Reproductive system;reproductive system disorder;Ribonucleoproteins;RNA;Role;Series;Site;Somatic Cell;Specific qualifier value;sperm cell;stoichiometry;Structure;Teratoma;Testing;Time;Transgenic Organisms;Translations;Variant;X-Ray Crystallography

PROJECT_TITLE: Molecular mechanisms of cell fate determinant assembly

STUDY_SECTION_NAME: Development - 2 Study Section[DEV2]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Hematology;Infectious Diseases;Neurosciences;Sepsis

ORG_CITY: Columbus

ORG_DEPT: NEUROSURGERY

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE Sepsis is a common, severe condition caused by the body’s response to an overwhelming infection. Sepsis survivors often face long-term problems with learning and memory. We will study how small sugar fragments and prion related protein, released by damaged blood vessels during sepsis, are taken up by the brain— thereby causing memory loss.

PI_NAMEs: HERSON, PACO S (contact);SCHMIDT, ERIC PETER

PROGRAM_OFFICER_NAME: CATANIA, SELEN MURATOGLU

PROJECT_TERMS: Acceleration;Affinity Chromatography;Animal Model;Animals;Binding Proteins;Biological Markers;Blood;Blood - brain barrier anatomy;Blood Circulation;blood damage;Blood Vessels;blood-brain barrier permeabilization;Brain;Brain Injuries;Cause of Death;Chronic;Circulation;clinical investigation;Clinical Research;Cognitive;cohort;Collaborations;Critical Illness;Data;Dementia;Development;Dextrans;effective therapy;Electrophysiology (science);Endothelial Cells;Endothelium;experience;experimental study;Extravasation;Face;Functional disorder;Glycobiology;Glycocalyx;Glycosaminoglycans;Goals;Growth Factor;Heparin;Heparitin Sulfate;Hippocampus;Human;Impaired cognition;improved;Industrialization;Infection;injured;innovation;Interdisciplinary Study;International;Journals;Laboratories;Learning;Lipopolysaccharides;Lung;Manuscripts;Mediator;Memory;Memory Loss;Methods;Modeling;Molecular;mortality;multidisciplinary;Mus;neurobehavior;Neurocognitive;novel;Outcome;overexpression;patient population;Patients;Penetration;prevent;Prions;prospective;Proteins;Proteomics;Publishing;response;Role;Sepsis;septic;septic patients;Societies;spatial memory;Specificity;Stream;sugar;Supportive care;Survivors;Testing;therapeutic target;Tissues;tool;translational impact;United States National Academy of Sciences;uptake;Work

PROJECT_TITLE: Vascular mechanisms of sepsis-induced cognitive dysfunction

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ISB-D(02)M]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Bioengineering;Genetics;Hematology;Human Genome;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: Narrative Our chromosomes are intricately organized in the nuclei of our cells, and the principles underlying this organization are important to understand since perturbations can cause disease. Here we propose to study the function of a protein, called Ldb1, that our prior work suggests to be a critical chromosomal organizer in red blood cell precursors. We will examine how Ldb1 contributes to chromosome folding and regulation of gene expression.

PI_NAMEs: BLOBEL, GERD A (contact)

PROGRAM_OFFICER_NAME: HATTANGADI, SHILPA MANOHAR

PROJECT_TERMS: Acceleration;Acute;Adaptor Signaling Protein;Architecture;Auxins;beta Globin;Binding;Binding Sites;Biological Assay;Categories;Cell Cycle;Cell Cycle Progression;Cell Differentiation process;Cell Line;Cell Maturation;Cell Nucleus;Cells;ChIP-seq;Chromatin;Chromatin Loop;Chromatin Modeling;Chromatin Structure;Chromosome Structures;Chromosomes;cofactor;cohesin;Collaborations;Complex;connectome;cost effective;Coupled;Data;Data Set;Defect;Dependence;Development;developmental disease;developmental genetics;Disease;Engineering;Enhancers;Erythroblasts;Erythrocytes;Erythroid;Erythroid Cells;erythroid differentiation;Excision;experimental study;follow-up;forging;Funding Agency;G1 Phase;G1/S Transition;GATA1 gene;Gene Activation;Gene Expression;Gene Expression Regulation;gene repression;Genes;Genetic Transcription;Genome;genome-wide;Hematopoietic stem cells;Hi-C;infancy;Influentials;insight;Interphase;Knowledge;Laboratories;Life;Maintenance;Malignant Neoplasms;Maps;Measurable;Measurement;Measures;Mechanics;Metaphase;Mitosis;Monitor;Mus;novel;Nuclear;Nucleic Acid Regulatory Sequences;Outcome;Pattern;Population;Precision Run-On Sequencing;Process;programs;promoter;Proteins;recruit;Research;Resolution;Role;Series;Structure;Sum;superresolution microscopy;synergism;System;TAL1 gene;Time;Tissues;tool;transcription factor;Untranslated RNA;virtual;Work;YY1 Transcription Factor

PROJECT_TITLE: Transcriptional Networks Controlling Erythroid Differentiation

STUDY_SECTION: BBHV

STUDY_SECTION_NAME: Basic Biology of Blood, Heart and Vasculature Study Section [BBHV]


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Immunotherapy;Neurosciences;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

PHR: PROJECT NARRATIVE The immune suppressive tumor microenvironment in glioblastoma (GBM) contributes to the failure of immune checkpoint blockers (ICBs). By reprogramming the GBM microenvironment using Wnt-inhibitor and losartan, our project will i) provide unprecedented insights into the mechanisms of response and resistance to combined Wnt signaling inhibition and αPD1, and ii) utilize losartan, a safe, inexpensive and widely prescribed angiotensin receptor blocker, to alleviate edema and resistance to this combination and thereby improve outcome of ICBs in GBM. If successful, our results will inform the design – and catalyze the initiation – of clinical trials in GBM patients to improve the outcome of ICBs using agents currently in clinical trials for non-CNS tumors (WNT974: e.g., NCT01351103; and losartan: NCT03563248).

PI_NAMEs: JAIN, RAKESH K. (contact)

PROGRAM_OFFICER_NAME: KUO, LILLIAN S

PROJECT_TERMS: Angiotensin Receptor;Anti-Hypertensive Agents;anti-PD-1;anti-PD1 antibodies;Antibodies;Antigen Presentation;Antigens;biomarker panel;Blood;bone cell;Bone Marrow;Brain Edema;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Central Nervous System Neoplasms;Chemoresistance;Clinical Trials;Coculture Techniques;Cross Presentation;Cytotoxic T-Lymphocytes;Data;Dendritic cell activation;Dendritic Cells;design;draining lymph node;Edema;effector T cell;epithelial to mesenchymal transition;Failure;Flow Cytometry;Future;Genetic;Glioblastoma;granulocyte;Human;Hypermethylation;Immune;immune checkpoint blockers;Immunosuppression;Immunotherapy;improved;improved outcome;Infiltration;inhibitor;insight;Interferon Type II;Long-Term Survivors;Losartan;Macrophage;Malignant Neoplasms;Measures;Mediating;Microglia;Modeling;monocyte;Mus;Myelogenous;Myeloid-derived suppressor cells;Newly Diagnosed;novel;Oral;Outcome;Pathway interactions;Patients;Perfusion;pharmacologic;phase III trial;Physiologic pulse;Porcupines;programs;Proliferating;Recurrence;Refractory;Regulatory T-Lymphocyte;Resistance;resistance mechanism;response;Role;single-cell RNA sequencing;Spleen;stem cells;stemness;Steroids;System;T cell infiltration;T-Lymphocyte;Testing;therapeutic target;therapy resistant;TNF gene;Toxic effect;treatment arm;treatment response;tumor;tumor growth;Tumor Immunity;tumor microenvironment;tumor-immune system interactions;Wild Type Mouse;WNT Signaling Pathway;Work

PROJECT_TITLE: Reprogramming the tumormicroenvironment to improve immunotherapy of glioblastoma


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

ORG_DEPT: SOCIAL SCIENCES

PHR: NARRATIVE This project will provide infrastructure support for a cutting edge program of research on population dynamics at the Carolina Population Center. Research at the Center will analyze state-of-the art data to address fundamental questions regarding fertility, adolescent health, and links between the environment and health. Special attention will be paid to factors creating health disparities.

PI_NAMEs: GUZZO, KAREN B (contact)

PROGRAM_OFFICER_NAME: CLARK, REBECCA L

PROJECT_TERMS: Address;Adolescent;adolescent health;Adopted;Adult;Age;Applications Grants;Area;Attention;Biological Markers;career;China;Cognitive;Collaborations;collaborative environment;Communication;Communities;Complex;Computer Vision Systems;cost;Creativeness;Data;data access;Data Collection;design;Development;Diffuse;Disparity;Educational workshop;empowerment;Environment;Ethnic Origin;experience;Extramural Activities;Faculty;faculty support;Family;Fertility;Fostering;Funding;Gender;Genetic;Grant;Hand;Health;health disparity;Health Surveys;Home;Inequality;Infrastructure;innovation;Institution;interdisciplinary collaboration;Intervention;Journals;Learning;Life Cycle Stages;Link;longitudinal dataset;Longitudinal Studies;Machine Learning;Mainstreaming;Measurement;Mentors;Methods;Natural experiment;novel strategies;Nutrition Surveys;Personal Satisfaction;Phase;Policy Maker;Policy Making;Population;Population Dynamics;Population Research;Population Sciences;Postdoctoral Fellow;privacy protection;Process;Production;Productivity;programs;Publishing;Race;Recovery;Reproduction;Research;Research Design;Research Infrastructure;Research Personnel;Research Project Grants;Resources;response;Schools;Science;Scientific Advances and Accomplishments;Scientist;Services;Sexuality;Shapes;sociodemographic variables;Socioeconomic Status;Structure;Students;success;Surveys;Talents;Teacher Professional Development;Technical Expertise;Techniques;tool;Training Programs;Tsunami;Universities;Work

PROJECT_TITLE: Carolina Population Center


PROJECT_TERMS: Area;Collaborations;Communication;Communities;Complex;cost effective;Creativeness;design;Development;Educational workshop;Environment;Faculty;falls;Funding;Grant;innovation;innovative technologies;Life Cycle Stages;Methods;Monitor;Needs Assessment;Phase;Play;Population;Population Sciences;Process;Productivity;Progress Reports;recruit;Research;research and development;Research Project Grants;Role;Science;Scientific Advances and Accomplishments;Scientist;Senior Scientist;Service provision;Services;success;Testing;Time;Work;working group;Writing

PROJECT_TITLE: Carolina Population Center Administrative Core


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences;Nutrition;Opioids

ORG_CITY: SAINT LOUIS

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative Over the course of a lifetime, 20% of adults in the United States will experience mental illness. Many neuropsychiatric disorders are characterized by dysregulation of affective or motivated circuits in the brain, both of which are highly sensitive to endogenous opioid signaling. Here, we seek to leverage next-generation, opioid specific technologies to determine the biological and computational function of endogenous opioids in regulating motivated behaviors.

PI_NAMEs: CASTRO, DANIEL CHARLES (contact)

PROGRAM_OFFICER_NAME: FERNANDEZ, FERNANDO R

PROJECT_TERMS: Adult;Affect;Affective;Analgesics;Anatomy;antagonist;Behavior;behavior test;Behavioral;Biological;biological adaptation to stress;Bite;Brain;Calcium;calcium indicator;Cell Nucleus;cell type;Characteristics;Chronic;Clustered Regularly Interspaced Short Palindromic Repeats;Code;Color;CRISPR/Cas technology;Data;delta opioid receptor;design;Desire for food;Devices;Dissociation;Dorsal;dorsal raphe nucleus;Eating;Electric Stimulation;endogenous opioids;Endoscopy;Enkephalin Receptors;Enkephalins;experience;experimental study;Fluorescent in Situ Hybridization;fluorophore;follow-up;Genetic;Goals;Health Care Costs;Image;in vivo imaging;increased appetite;Individual;insight;knock-down;Lateral;Ligands;Measures;Mediating;Mental disorders;Microinjections;midbrain central gray substance;Midbrain structure;Moods;Morphine;motivated behavior;Motivation;mu receptors;Mus;National Institute of Mental Health;neural;neural circuit;neurobiological mechanism;neurochemistry;Neurons;neuropsychiatric disorder;neuropsychiatry;neuroregulation;next generation;Nucleus Accumbens;Opioid;Opioid agonist;Opioid Peptide;Opioid Receptor;Opsin;optogenetics;Pattern;Peptides;pharmacologic;Pharmacology;Phenotype;Photons;Pilot Projects;Play;Process;receptor;receptor expression;redshift;Regulation;response;Rewards;Role;Signal Transduction;Site;Strategic Planning;System;Tail;targeted treatment;Technology;Testing;Therapeutic Intervention;United States;Virus;wireless;wireless implant

PROJECT_TITLE: Investigating non-canonical mechanisms of endogenous opioids on motivation in dorsal midbrain

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


NIH_SPENDING_CATS: Clinical Research

PI_NAMEs: THOMPSON, AMANDA L (contact)

PROJECT_TERMS: Address;Applications Grants;Attention;Biological;Calendar;career;Cognitive;Collaborations;Data;Dedications;design;Development;Dimensions;Educational workshop;Faculty;Feeds;Financial Support;flexibility;Funding;Goals;Grant;Health;human capital;innovation;Investments;Learning;Life Cycle Stages;Lightning;Measurement;Mentors;mid-career faculty;Population;Population Dynamics;Population Sciences;Preparation;Process;Productivity;programs;Recording of previous events;Research;research and development;Research Personnel;Research Project Grants;Resources;response;Schedule;Scientist;Seasons;senior faculty;Series;Services;social;social capital;Speed;Structure;Technology;United States National Institutes of Health;Work;Writing

PROJECT_TITLE: Carolina Population Center Development Core


NIH_SPENDING_CATS: Networking and Information Technology R&D (NITRD)

PI_NAMEs: MOUW, TED  (contact)

PROJECT_TERMS: Adoption;Archives;Biological;Biological Markers;career;Collection;Complex;complex data;Computer software;computing resources;Data;data acquisition;Data Analyses;Data Collection;data dissemination;data portal;Data Set;data sharing;Databases;design;Development;Diffusion;Documentation;Ensure;Environment;experience;Faculty;Funding;Generations;Grant;High Performance Computing;improved;Individual;Information Technology;innovation;Institutional Review Boards;Life Cycle Stages;Mainstreaming;member;Methodology;Methods;Modeling;novel strategies;Pilot Projects;Population;Population Research;Population Sciences;Production;Productivity;programs;Protocol Compliance;Research;Research Activity;Research Design;Research Infrastructure;Research Personnel;Research Project Grants;Secure;Services;skills;Statistical Data Interpretation;statistics;Surveys;Tablets;Testing;Training Activity;Work

PROJECT_TITLE: Carolina Population Center Research Services Core


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Drug Abuse (NIDA only);Neurosciences;Substance Misuse;Tobacco

PHR: PROJECT NARRATIVE We propose to identify the distinct functional clusters of anterior cingulate cortex (ACC), an addiction hub in the brain, during attention deployment in nicotine addiction. Successful completion of this work will provide the evidence of the neural basis of addiction-derived attention alternations, leading to novel insights into the neurophysiological foundation of the addiction-related network interaction.

PI_NAMEs: HSU, LI-MING  (contact);SHIH, YEN-YU IAN

PROGRAM_OFFICER_NAME: MOORE, HOLLY MARIE

PROJECT_TITLE: Concurrent high resolution calcium imaging and fMRI reveal intra anterior cingulate cortex neuronal activity and large-scale brain network connectivity in healthy and nicotine-addicted mice


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics;Neurosciences

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Retinal vascular diseases are major causes of vision loss. Heme is a co-factor critical for oxygen transport, metabolism, and gene transcription. Our goal in this proposal is to determine how heme regulates retinal angiogenesis and contributes to retinal vascular diseases.

PI_NAMEs: ANTONETTI, DAVID ;ARNOLD, THOMAS DARMODY (contact)

PROGRAM_OFFICER_NAME: GORDIYENKO, NATALIYA

PROJECT_TERMS: Age related macular degeneration;Alleles;angiogenesis;Area;Back;beta catenin;Blindness;Blocking Antibodies;Blood capillaries;Blood Vessels;Brain;Cell Culture Techniques;Cells;Central Nervous System;Choroidal Neovascularization;cofactor;Collaborations;Coupled;Data;Defect;Development;Diabetic Retinopathy;Disease;Down-Regulation;Endothelial Cells;Endothelium;experimental study;Family;Feline Leukemia Virus;Gene Deletion;Gene Expression Regulation;Genes;Genetic;genetic approach;genetic manipulation;Genetic Transcription;Goals;Growth;Heme;Hemin;Human;Hypoxia;Impairment;In Vitro;in vivo;inhibitor;knock-down;Knock-in;Knock-out;Knockout Mice;Laboratories;Lasers;Link;Mediating;Medical;Membrane;Metabolism;Modeling;mouse model;Mus;Mutate;Mutation;Natural regeneration;neovascularization;Norrie's disease;notch protein;novel;novel therapeutic intervention;overexpression;Oxygen;oxygen transport;Patients;Perfusion;pharmacologic;Phenocopy;Phenotype;prenatal;Primary Cell Cultures;Production;Proliferating;Publications;Publishing;receptor;Regulation;Research;Retina;retina blood vessel structure;retinal angiogenesis;Retinal Diseases;Retinal Neovascularization;Retinal Vein Occlusion;Retinopathy of Prematurity;Role;Signal Pathway;Signal Transduction;Syndrome;System;Testing;Tissues;tool;trafficking;Transgenic Organisms;Treatment Factor;United States;uptake;Vascular Diseases;Vascular Endothelial Growth Factors;Vascularization;Vision

PROJECT_TITLE: The role of heme in retinal vascular development and disease

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 1 Study Section[PED1]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Mental Health;Neurodegenerative;Neurosciences;Nutrition;Prevention

ORG_CITY: LEXINGTON

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: Project Narrative Novel biomarkers of Alzheimer’s disease (AD) are needed to aid early identification of individuals at high AD-risk. This study will test the accuracy of brain iron neuroimaging as a predictor AD-related neurocognitive declines. It is anticipated that findings from this study will improve the ability to detect early AD and track changes in cognitive status during disease progression.

PI_NAMEs: GOLD, BRIAN TIMOTHY (contact)

PROGRAM_OFFICER_NAME: WAGSTER, MOLLY V

PROJECT_TERMS: Affect;age related;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease risk;Alzheimer’s disease biomarker;American;Amyloid beta-Protein;Antioxidants;Attenuated;base;behavior measurement;Biological Markers;blood-brain barrier crossing;Brain;brain based;brain iron;Cerebrospinal Fluid;Clinical;Cognition;Cognitive;Cognitive aging;cognitive function;cognitive process;cognitive reserve;Compensation;Diet;Diffusion Magnetic Resonance Imaging;Disease Progression;Early Diagnosis;Early identification;Early Intervention;Episodic memory;Functional Magnetic Resonance Imaging;functional plasticity;Goals;good diet;Health;Image;Impaired cognition;improved;in vivo;indexing;Individual;inflammatory marker;Intake;Iron;lifestyle factors;Linear Regressions;Liquid substance;Magnetic Resonance Imaging;Maintenance;Maps;Measures;Mediating;Memory;Memory Loss;Modeling;MRI Scans;neural;Neurocognitive;Neurocognitive Deficit;neuroimaging;neuroimaging marker;Neuropsychology;novel;novel marker;older adult;Participant;Pathologic;Pathology;Pattern;Performance;Plasma;Positron-Emission Tomography;pre-clinical;Predisposition;protective factors;Regression Analysis;Sampling;Scanning;Short-Term Memory;Signal Transduction;support network;System;tau Proteins;tau-1;Testing;Time;white matter

PROJECT_TITLE: Identifying Associations between Brain Iron, Neurocognitive Networks and Protective Factors


NIH_SPENDING_CATS: Behavioral and Social Science;Biotechnology;Clinical Research;Cost Effectiveness Research;Genetics;Health Services;Human Genome;Pediatric;Rare Diseases

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE  Though any single rare disease is by definition uncommon, together these diseases affect nearly 30 million individuals in the United States, two-thirds of whom are children, and contribute significantly to morbidity, mortality, and healthcare costs. Exome and whole genome sequencing have the potential to provide a diagnosis to an estimated 25 to 50 percent of those patients struggling with undiagnosed rare diseases, but the downstream costs and benefits of this testing beyond diagnosis remain largely unknown. This study will contribute essential and timely data, new methods, and ethical analyses to inform both how we can, and how we should, define and measure the value of genome sequencing for pediatric patients with rare diseases.

PI_NAMEs: HALLEY, MEGHAN  (contact)

PROGRAM_OFFICER_NAME: KAUFMAN, DAVE J

PROJECT_TERMS: Affect;Anthropology;Bioethics;career;Caregivers;Child;Clinical;clinical care;Clinical Management;cost;Cost Analysis;Costs and Benefits;Data;design;Development;Diagnosis;Diagnostic;Disease;economic evaluation;Ensure;Equity;Ethical Analysis;ethical, legal, and social implication;Ethics;ethnographic method;Ethnography;exome;experience;Family;Family health status;follow-up;Foundations;Future;Future Generations;General Population;Genetic;Genetic Diseases;genetic testing;Genome;genome sequencing;Genomics;Goals;Health;Health Care Costs;health care service utilization;health economics;Health Policy;health related quality of life;Health Services Research;Healthcare Systems;Imagination;Individual;individual patient;innovation;insight;interdisciplinary approach;Intervention;Knowledge;Lived experience;Long-Term Effects;Maps;Measurement;Measures;Medical;Medicine;Mentors;Methodology;Methods;Modern Medicine;Morbidity - disease rate;mortality;novel strategies;Outcome;Patients;pediatric patients;Perception;Personal Satisfaction;physical conditioning;policy recommendation;preference;psychologic;psychosocial;Rare Diseases;rare genetic disorder;relative cost;Research;research clinical testing;Research Personnel;response;Scientist;skills;social;Social Well-Being;stakeholder perspectives;Surface;Technology;Testing;tool;Training;United States;variant of unknown significance;whole genome;Work

PROJECT_TITLE: Surfacing values in the economic evaluation of genomic sequencing for diagnosis of children with rare diseases


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: HIV/AIDS;Infectious Diseases

ORG_CITY: CHICAGO

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: PROJECT NARRATIVE Several aspects of the early stages of HIV-1 infection remain poorly understood. Our recent work identified two new classes of host co-factors that bind HIV-1 capsids through distinct strategies, including one that uses a previously undescribed recognition strategy that we hypothesize supports HIV-1 metastability and is an evolutionary driver for HIV-1's use of less conventional motor adaptors. This proposal will employ cutting-edge cryoEM, biochemical and functional approaches to test this hypothesis and understand how these factors engage the HIV-1 core to control early infection.

PI_NAMEs: NAGHAVI, MOJGAN HOSSEINI (contact);PORNILLOS, OWEN

PROGRAM_OFFICER_NAME: REFSLAND, ERIC WILLIAM

PROJECT_TERMS: Adaptor Signaling Protein;Amino Acids;Area;Automobile Driving;Binding;Binding Sites;Biochemical;Biochemistry;Capsid;Capsid Proteins;Cell Nucleus;Charge;CLIP-170 gene;cofactor;Coiled-Coil Domain;Complex;Cone;Conflict (Psychology);Cryoelectron Microscopy;Cyclophilin A;Cytoplasmic Protein;Cytosol;Data;dynactin;dynactin 1;Dynein ATPase;Elongation Factor;genetic regulatory protein;Goals;HIV-1;Homologous Gene;Image;In Vitro;Infection;insight;Integration Host Factors;Intracellular Transport;Kinesin;Left;Mediating;Microtubules;Modeling;Motor;Movement;mutant;novel;particle;Process;Proteins;recruit;Research;Shapes;Structure;Tertiary Protein Structure;Testing;Tubular formation;Viral;Viral Genome;Viral Reverse Transcription;Work

PROJECT_TITLE: +TIPs as novel host capsid-binding co-factors in early HIV-1 infection


PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it is focused on the study of pathways, drugs, and drug targets for the inherited neuro- and cardio-degenerative disease, Friedreich ataxia, which currently has no approved treatments. The proposed research seeks to reduce the burden of this serious disease and is therefore relevant to the mission of the NIH, and particularly the missions of the NINDS and the NHLBI.

PI_NAMEs: WILSON, ROBERT B (contact)

PROGRAM_OFFICER_NAME: RANGANATHAN, SRIKANTH

PROJECT_TERMS: Affect;Afferent Neurons;Antioxidants;Ataxia;autosome;Biogenesis;biological adaptation to stress;Cardiac Myocytes;Cardiomyopathies;cell type;Cells;Chronic;clinical development;Clinical Trials;Complex;Defect;Degenerative Disorder;Disease;DNA Damage;Drug Targeting;Environment;Enzymes;Exhibits;Feedback;Fibroblasts;frataxin;Friedreich Ataxia;Functional disorder;Genes;Genetic;genetic approach;Goals;Growth;Human;In Vitro;in vivo;induced pluripotent stem cell;induced pluripotent stem cell derived cardiomyocytes;Inherited;inhibitor;Investigational Therapies;Iron;Length;Link;Lipid Peroxidation;MAP Kinase Gene;Mission;Mitochondria;mitochondrial dysfunction;Mitochondrial Matrix;model organism;Modeling;mouse model;Mutation;National Heart, Lung, and Blood Institute;National Institute of Neurological Disorders and Stroke;Oxidative Stress;p38 Mitogen Activated Protein Kinase;Pathogenesis;Pathway interactions;Pharmaceutical Preparations;Phenotype;Prosthesis;Proteins;Public Health;Research;response;Role;screening;Secondary to;small molecule;Sulfur;System;telomere;telomere damage;Telomere Shortening;Testing;Therapeutic;Therapeutic Effect;Therapeutic Intervention;therapeutic target;Time;United States National Institutes of Health;Whole Organism;Zebrafish

PROJECT_TITLE: p38 MAPK activation as a therapeutic target for Friedreich ataxia

STUDY_SECTION: TAG

STUDY_SECTION_NAME: Therapeutic Approaches to Genetic Diseases Study Section[TAG]


NIH_SPENDING_CATS: Cancer

ORG_CITY: MIAMI

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: FLORIDA INTERNATIONAL UNIVERSITY

ORG_STATE: FL

PHR: Project Narrative Arsenic is the most pervasive environmental toxin and carcinogen in the United States, causing cardiovascular and peripheral vascular diseases, neurological disorders, diabetes mellitus and various forms of cancer such as skin and bladder cancer. The overarching theme of this long-standing project is both a comprehensive and in depth understanding of the biology of arsenic, and, in this application we propose to elucidate the genes, enzymes, transporters and mechanisms in the pathways of arsenic biology.

PI_NAMEs: ROSEN, BARRY P. (contact)

PROGRAM_OFFICER_NAME: SIMONOVIC, MILJAN

PROJECT_TERMS: Acetyltransferase;Affect;anti-microbial drug;Antibiotics;Arsenic;Arsenicals;Arsenites;Biochemical;Biochemistry;Biology;Biosensing Techniques;Biosensor;Cancer Etiology;Cardiovascular system;Categories;Childhood;Crystallography;Developmental Delay Disorders;Diabetes Mellitus;Environmental Carcinogens;enzyme structure;Enzymes;falls;Flowers;Funding;Genes;Goals;Grant;Health;health application;Heart Diseases;Herbicides;Human;Human Microbiome;Lyase;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Metabolic Biotransformation;Methylation;Methyltransferase;microbial genome;Molecular;Molecular Genetics;National Institute of General Medical Sciences;Natural Products;Nervous System Disorder;novel;Oxidases;Pathway interactions;Peripheral Vascular Diseases;permease;Physiological;pollutant;programs;Proteins;Qualifying;Recording of previous events;Regulation;Research;Resistance;resistance gene;Role;Skin Cancer;Structure;Toxic effect;Toxic Environmental Substances;Toxin;United States;Vision

PROJECT_TITLE: MECHANISMS OF ARSENIC TRANSPORT AND BIOTRANSFORMATIONS

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-B(55)R]


ADMINISTERING_IC: NR

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Cardiovascular;Cerebrovascular;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Neurosciences;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Telehealth

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: Narrative The Coronavirus 2019 (COVID-19) pandemic created disruptions in usual medical care delivery that could have devastating downstream effects. Older adults living in rural areas experience worse health outcomes than their urban counterparts, and may be particularly vulnerable to care disruption, particularly if they also live in poverty or are members of racial or ethnic minority groups. In this project, we seek to understand the magnitude and clinical impact of COVID-related clinical care disruption, with a focus on vulnerable rural communities.

PI_NAMEs: JOYNT MADDOX, KAREN ELLEN (contact)

PROGRAM_OFFICER_NAME: GODETTE, DIONNE

PROJECT_TERMS: acute care;Adult;Ambulatory Care;Cardiovascular Diseases;Cardiovascular system;care delivery;Caring;cerebrovascular;Cerebrovascular Disorders;Chronic Care;Chronic Disease;Clinical;clinical care;clinical effect;Coronavirus;COVID-19;COVID-19 impact;Data;Database Management Systems;Disease Outcome;Economic Conditions;Economics;Equity;ethnic minority;ethnic minority population;experience;Future;future outbreak;Goals;Health;health care delivery;health management;Health Services Accessibility;Health system;Hospitals;Individual;Inpatients;Medical;Medicare claim;member;Monitor;older adult;Outcome;Outpatients;pandemic disease;pandemic disruption;Patients;Persons;poor health outcome;population health;Poverty;Procedures;racial minority;racial minority population;Resources;Risk;Rural;rural area;Rural Community;rural healthcare;Rural Hospitals;Rural Population;social;Social Conditions;Social isolation;Subgroup;telehealth;Travel;urban area;urban disparity;Work

PROJECT_TITLE: Rural-Urban Disparities In Spillover Effects of COVID-19


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Heart Disease;Hypertension;Kidney Disease;Pediatric;Precision Medicine;Prevention;Sleep Research

ORG_CITY: MANHASSET

ORG_NAME: FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH

PHR: PROJECT NARRATIVE The proposed research will further knowledge about the cardiovascular risks, clinical predictors and molecular markers that drive nocturnal blood pressure dysregulation (nocturnal hypertension and non-dipper status) in children with proteinuric glomerulopathies. The long-term goal is to guide prevention and treatment for nocturnal blood pressure dysregulation to meaningfully improve cardiovascular disease outcomes in children with proteinuric glomerulopathies. The precision medicine approach employed in this study provides an individualized, patient-oriented approach to nocturnal blood pressure dysregulation, which is critical for the prevention of future cardiovascular morbidity and mortality in these high-risk children.

PI_NAMEs: SETHNA, CHRISTINE B (contact)

PROGRAM_OFFICER_NAME: EINHORN, PAULA T

PROJECT_TERMS: actigraphy;Adult;Age;Ambulatory Blood Pressure Monitoring;American Heart Association;arterial stiffness;Atherosclerosis;Bioinformatics;Blood Pressure;Cardiac;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;cardiovascular risk factor;Cardiovascular system;Child;Child Health;Chronic Kidney Failure;circadian;Clinical Data;Clinical Markers;clinical predictors;cohort;Data;data integration;design;Development;differential expression;Disease;Disease Marker;Disease Outcome;Dyslipidemias;Echocardiography;Enrollment;experience;fatty acid metabolism;Functional disorder;Funding;Future;Gene Expression;Genes;Genomics;Goals;Guide prevention;Health;High Prevalence;high risk;high risk population;Home;Hour;Hydrocortisone;Hypertension;improved;indexing;Inflammation;innovation;Intake;Investigation;Kidney;Knowledge;Laboratories;Left;Left Ventricular Dysfunction;Left Ventricular Hypertrophy;Left Ventricular Mass;Link;Lipids;Longitudinal Studies;Longitudinal, observational study;Machine Learning;machine learning method;Measurement;Measures;Metabolic;metabolomics;Methodology;Molecular;molecular marker;Morbidity - disease rate;mortality;Multiomic Data;Nephrotic Syndrome;Nocturnal Hypertension;novel;observational cohort study;Organ;Outcome;Pathologic;Pathway interactions;patient oriented;Patients;Pattern;Phenotype;Physical activity;Physiologic pulse;Population;precision medicine;predictive marker;predictive modeling;Prevention;Proteomics;Questionnaires;randomized, clinical trials;Rare Diseases;Renal glomerular disease;Research;Risk;Risk Factors;Risk Marker;Risk Reduction;Salivary;Sleep;Sleep Apnea Syndromes;sleep quality;Sodium;Systems Biology;Time;transcriptome;transcriptomics;United States National Institutes of Health;Validation;Ventricular;Whole Blood;Work

PROJECT_TITLE: Kids: Nocturnal Investigation into Glomerular Disease, Hypertension, and Transcriptomics (kNIGHT)

STUDY_SECTION: CHSB

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology B Study Section[CHSB]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Cardiovascular;Genetics

ORG_CITY: TUCSON

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: PROJECT NARRATIVE Mutations in myosin binding protein-C (MyBP-C), a muscle regulatory protein, are increasingly linked to congenital skeletal muscle diseases including those that cause clubfoot and familial tremors, but the role of MyBP-C in normal muscle function and the mechanism(s) by which mutations cause disease remain poorly understood. Here, we describe a new approach developed exclusively in the PI’s lab that will allow us for the first time to selectively modify MyBP-C in working muscles in real time. Results from this study will provide critical insights into how MyBP-C regulates muscle function and how mutations cause disease.

PI_NAMEs: HARRIS, SAMANTHA P (contact)

PROGRAM_OFFICER_NAME: LINDHURST, MARJORIE JEAN

PROJECT_TERMS: Acute;Affect;Alternative Splicing;Arthrogryposis;Cardiac;Cardiac Myocytes;Cardiac Myosins;Complex;Congenital clubfoot;Consensus;Contracture;covalent bond;Data;Data Analyses;Defect;Detergents;Development;differential expression;Disease;disease-causing mutation;Distal;Excision;Familial Tremors;Family;Fiber;Functional disorder;gene product;Genes;Genetic Engineering;genetic regulatory protein;Goals;Hypertrophic Cardiomyopathy;In Situ;In Vitro;insight;Knock-out;Knockout Mice;Link;Methods;Modeling;Modification;mouse model;Mus;Muscle;Muscle Cells;Muscle Contraction;Muscle Fibers;Muscle function;Muscle Tremors;Mutation;Myocardium;Myopathy;myosin-binding protein C;N-terminal;novel;novel strategies;paralogous gene;Paste substance;Permeability;Persons;Phosphorylation;Post-Translational Protein Processing;prevent;Protein Splicing;Proteins;Recombinant Proteins;Recombinants;Relaxation;Reporting;RNA Splicing;Role;Sarcomeres;Site;skeletal;Skeletal Muscle;Syndrome;TEV protease;Time;Tremor;Up-Regulation;Variant;Work

PROJECT_TITLE: Cut and paste of myosin binding protein-C in skeletal muscles

STUDY_SECTION: SMEP

STUDY_SECTION_NAME: Skeletal Muscle and Exercise Physiology Study Section[SMEP]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences

ORG_DEPT: PSYCHIATRY

PHR: PROJECT NARRATIVE Significant microstructural changes occur in the brain years before clinical manifestation of Alzheimer’s disease (AD). However, there is gap in reliable and sensitive in vivo measurement of early molecular and microstructural changes in prodromal AD. We will integrate advanced quantitative MRI markers of gray and white matter microstructural changes, network neuroscience, and longitudinal outcomes to examine subtle changes in brain microstructure in preclinical AD in association with AD pathology and cognitive decline, and to further improve our mechanistic understanding of AD.

PI_NAMEs: HOSSEINI, HADI  (contact)

PROJECT_TERMS: Affect;Aging;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease patient;amnestic mild cognitive impairment;Amyloid;Amyloid beta-Protein;Animals;Autopsy;Axonal Transport;Behavior;Brain;brain morphology;brain tissue;Clinical;Cognition;Cognitive;Cognitive deficits;Communities;compare effectiveness;connectome;Consensus;Data;density;Detection;Development;Diagnosis;Diffusion;Disease;disease heterogeneity;Disease Outcome;Effectiveness;Evaluation;extracellular;gray matter;Heterogeneity;Hippocampus;histological studies;Human;Image;Impaired cognition;improved;in vivo;indexing;insight;Investigation;Knowledge;Link;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Maps;Measurement;Measures;Medial;mild cognitive impairment;Modality;Modeling;Molecular;Monitor;Morphology;Myelin;Nerve Degeneration;Neurites;Neurobiology;Neurofibrillary Tangles;neuroimaging;Neurons;neuropathology;Neurosciences;novel;older adult;older patient;Outcome;Parietal Lobe;Pathology;Phenotype;Positron-Emission Tomography;pre-clinical;predictive marker;Process;prodromal Alzheimer's disease;Property;Prospective Studies;Reproducibility;Research Personnel;Resources;Sampling;Senile Plaques;Signal Transduction;Structure;Synapses;tau Proteins;Techniques;Testing;Tissues;white matter

PROJECT_TITLE: Microstructural changes in gray and white matter in aging and AD

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


ADMINISTERING_IC: DC

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Hearing Loss;Neurosciences;Patient Safety;Prevention;Rehabilitation

ORG_CITY: Bozeman

ORG_NAME: RESTOREAR DEVICES, LLC

ORG_STATE: MT

PHR: Public health relevance: Restor-Ear Devices is the designer of devices that deliver localized therapeutic hypothermia to the inner ear during cochlear implantation. In collaboration with the University of Miami, the safety and efficacy of these devices will be validated in a clinical population. The results will lead to a major therapeutic advancement for hearing preservation in patients undergoing cochlear implantation.

PI_NAMEs: KING, CURTIS SCOTT (contact);RAJGURU, SUHRUD M.

PROGRAM_OFFICER_NAME: MILLER, ROGER

PROJECT_TERMS: Acoustics;Address;Adult;Americas;Audiology;biomaterial compatibility;Blood Vessels;Cadaver;clinic ready;Clinical;clinical application;Clinical Data;Clinical Engineering;clinical translation;clinically relevant;Cochlea;Cochlear implant procedure;Cochlear Implants;Collaborations;commercialization;Coupled;Data;design;Deterioration;Development;Device Designs;Device Safety;Devices;Drug Delivery Systems;Ear;Educational workshop;effective therapy;Electric Stimulation;Electrophysiology (science);Engineering;Ensure;experience;experimental study;Frequencies;Funding;Goals;Grant;Hair Cells;hazard;Head and Neck Surgery;Hearing;hearing preservation;Human;Implant;implantable device;implantation;Implanted Electrodes;improved;Industry;Inflammation;Inpatients;Intellectual Property;Labyrinth;Lead;manufacture;Manufacturer;Marketing;Measurement;Measures;Mechanics;Modification;Music;National Institute on Deafness and Other Communication Disorders;natural hypothermia;neural;Neurons;neuroprotection;novel;Operating Rooms;Operative Surgical Procedures;Otolaryngology;Outcome;patient prognosis;Patients;Phase;Population;Positioning Attribute;Postoperative Period;pre-clinical;pre-clinical research;preclinical study;preservation;Process;Program Development;programs;Protocols documentation;prototype;public health relevance;Publishing;Research;research and development;Research Contracts;Residual state;Risk;Rodent Model;Safety;Sensorineural Hearing Loss;Sensory Hair;speech in noise;Speech Perception;standard of care;Sterilization;Steroids;Structure;System;Technology;Testing;Therapeutic;Therapeutic Uses;therapy design;therapy outcome;Time;Trauma;Treatment Efficacy;Universities;Validation

PROJECT_TITLE: Device to Deliver Intra-Operative Therapeutic Hypothermia for Hearing Preservation in Cochlear Implantation


NIH_SPENDING_CATS: Cardiovascular;Heart Disease

ORG_NAME: RUSH UNIVERSITY MEDICAL CENTER

PHR: NARRATIVE Cardiovascular diseases, including cardiac arrhythmias and heart failure, are among the leading causes of morbidity and mortality, and are responsible for significant healthcare costs in the USA. This study seeks to identify the mechanisms of cellular calcium regulation that sustain the pump function of the heart, and to identify the disturbances and dysregulations of calcium signaling that lead to arrhythmias of the atria in the etiopathology of heart failure.

PI_NAMEs: BANACH, KATHRIN  (contact)

PROGRAM_OFFICER_NAME: SHI, YANG

PROJECT_TERMS: Action Potentials;Arrhythmia;Atrial Fibrillation;Calcium;Calcium Signaling;Cardiac;Cardiovascular Diseases;Coupling;Data;Endowment;Functional disorder;Generations;Goals;Health Care Costs;Heart Atrium;Heart failure;heart function;inorganic phosphate;Inositol;ITPR1 gene;Laboratories;Link;Mediating;Membrane;Mitochondria;Modeling;Morbidity - disease rate;mortality;Muscle Cells;NADPH Oxidase;Nuclear;nuclear factors of activated T-cells;Pacemakers;Peripheral;Physiological;Physiology;Pilot Projects;Play;Post-Translational Protein Processing;Predisposition;Process;Pump;Reactive Oxygen Species;receptor;Regulation;release factor;response;Risk;Role;Ryanodine Receptor Calcium Release Channel;Sarcoplasmic Reticulum;sex;Sex Differences;sexual dimorphism;Signal Transduction;Source;spatiotemporal;System;Testing;Tissues;transcription factor;Transcription Initiation;Transcriptional Regulation;Up-Regulation;Ventricular;Work

PROJECT_TITLE: IP3 receptor, NOX2 and calcium signaling domains in atrial physiology and pathophysiology

STUDY_SECTION: MPPB

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology B Study Section[MPPB]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biotechnology;Clinical Research;HIV/AIDS;Infectious Diseases;Prevention

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative. Virus resistance remains the central vulnerability of effective bnAb use in HIV. This application proposes to address the problem of bNAb resistance by rationally selecting combination bNAb therapy that limits virus escape. Our scientific premise is that in vivo mapping of virus escape from bNAbs, identification of complementary bNAbs, defining the role of autologous antibodies, and rigorous in vivo testing in an authentic NHP model will elucidate basic mechanisms of virus resistance to bNAbs and inform more effective use of bNAbs across the HIV prevention, treatment and cure fields.

PI_NAMEs: BAR, KATHARINE JUNE (contact);LYNCH, REBECCA MARIE

PROGRAM_OFFICER_NAME: JANCI, ELIZABETH WONDERLICH

PROJECT_TERMS: adaptive immune response;adaptive immunity;Address;AIDS prevention;Algorithms;antagonist;Antibodies;Antibody Response;Antibody Therapy;Autologous;B-Cell Antigen Receptor;B-Lymphocytes;Bar Codes;Binding;Binding Sites;Cellular biology;Clinical Trials;clinically relevant;cohort;Collection;Combined Modality Therapy;Data;Data Set;Development;Disease;Epitopes;Evolution;Face;Genetic Drift;Goals;Growth;HIV;HIV-1;humanized mouse;improved;In Vitro;in vivo;in vivo evaluation;Infection;Intervention;Kinetics;life span;Maps;Measurement;Measures;Modeling;Molecular Virology;multidisciplinary;Mutation;Natural Immunity;neutralizing antibody;novel;Outcome;Participant;Pathway interactions;Pharmaceutical Preparations;Phenotype;Plasma;Polysaccharides;Population;precision medicine;pressure;prevent;Prevention;Prevention trial;rational design;Resistance;resistance mechanism;Resource Development;response;Role;Sampling;Secure;Silicon Dioxide;simian human immunodeficiency virus;Testing;Variant;Viral;viral resistance;Viremia;Virus;virus host interaction;Virus Replication;Work

PROJECT_TITLE: Complementing broadly neutralizing antibodies and autologous responses to restrict virus escape and durably suppress HIV-1


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Diabetes

PHR: PROJECT NARRATIVE β-Cell dysfunction and depletion are pathologic features of diabetes. A regenerative therapeutic strategy for diabetes, while promising in principle, is contingent upon successful development a method for selectively targeting replication-promoting compounds to the β-cell. The extraordinary power of medicinal chemistry and a rigorous experimental interrogation cascade will be leveraged to deliver a β-cell-selective regenerative compound and define the chemical/genetic “rules” that govern β-cell selective drug delivery based upon their unique biologic properties.

PI_NAMEs: ANNES, JUSTIN PIERCE (contact)

PROGRAM_OFFICER_NAME: HWA, ALBERT J

PROJECT_TERMS: Address;Affect;Affinity;American;Assessment tool;Beta Cell;Binding;Biochemical;Biological;Biological Assay;biophysical properties;Biophysics;blood glucose regulation;Cell Physiology;Cell Proliferation;cell regeneration;Cells;Cellular biology;Chelating Agents;chelation;Chemicals;clinical development;Clustered Regularly Interspaced Short Palindromic Repeats;CRISPR/Cas technology;Development;Diabetes Mellitus;diabetic;Diabetic mouse;Disease;disease model;Dose;Drug Delivery Systems;Drug Exposure;Drug Kinetics;drug metabolism;Drug Targeting;efficacy validation;experience;experimental study;Functional disorder;Genes;Genetic;growth promoting activity;Hospitalization;Human;Immune;improved;In Vitro;in vivo;insight;Insulin;interest;islet;Islets of Langerhans Transplantation;mass spectrometric imaging;Measurement;Measures;Methodology;Methods;Modeling;Molecular;Morbidity - disease rate;mortality;Mus;Natural regeneration;next generation;novel;Organ;Pathologic;Pathway interactions;Permeability;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacologic;Positioning Attribute;pre-clinical;preservation;prevent;Production;Property;regenerative;regenerative therapy;Rodent;Series;Solubility;Spectrometry, Mass, Electrospray Ionization;Streptozocin;Structure-Activity Relationship;System;targeted delivery;targeted treatment;Technology;technology platform;Therapeutic;therapeutic target;Tissues;tool;Transplantation;Work;Zinc

PROJECT_TITLE: Leveraging the Uniquely High Beta-Cell Zinc Content for Targeted Drug Delivery

STUDY_SECTION: CADO

STUDY_SECTION_NAME: Cellular Aspects of Diabetes and Obesity Study Section[CADO]


NIH_SPENDING_CATS: Cancer;Genetics;Hematology;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Stem Cell Research - Umbilical Cord Blood/ Placenta;Stem Cell Research - Umbilical Cord Blood/ Placenta - Non-Human

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: Project Narrative DNMT3A is a protein that is critical for proper differentiation of blood cells, and mutations of DNMT3A are commonly associated with a variety of blood disorders. Here, we propose to study the mechanisms through which DNMT3A works and how the mutations affect its function. The long-term goal is to find new strategies to treat blood disorders associated with DNMT3A mutations.

PI_NAMEs: GOODELL, MARGARET A. (contact)

PROGRAM_OFFICER_NAME: HATTANGADI, SHILPA MANOHAR

PROJECT_TERMS: Accounting;Acute Lymphocytic Leukemia;Acute Myelocytic Leukemia;Adult;adult stem cell;Affect;age related;Blood Cells;Bone Marrow;Cells;Characteristics;Chimera organism;Chromatin;Complex;CRISPR/Cas technology;Data;Development;Disease;DNA Maintenance;DNA Methylation;DNA Modification Methylases;DNA Sequence Alteration;Embryo;Epigenetic Process;epigenome;epigenome editing;fitness;Funding;Gene Expression;Genes;genome editing;Goals;Hematologic Neoplasms;Hematological Disease;Hematopoiesis;hematopoietic differentiation;hematopoietic stem cell differentiation;Hematopoietic stem cells;Hematopoietic System;Heterozygote;Human;insight;interest;Investigation;Knockout Mice;Lead;leukemia/lymphoma;Life;Molecular;Mosaicism;mutant;Mutate;Mutation;N-terminal;Outcome;Pathologic;Phase;Phenotype;programs;Progress Reports;promoter;Protein Isoforms;Proteins;Publications;Regulation;Role;self-renewal;single-cell RNA sequencing;Site;stem cells;Testing;Therapeutic;Tissues;Transplantation;Tumor Suppressor Proteins;ubiquitin-protein ligase;Work

PROJECT_TITLE: REGULATION OF HEMATOPOIETIC PROGENITORS BY DE NOVO DNA METHYLATION

STUDY_SECTION: MCH

STUDY_SECTION_NAME: Molecular and Cellular Hematology Study Section[MCH]


NIH_SPENDING_CATS: Aging;Genetics

ORG_CITY: New York

ORG_NAME: HOSPITAL FOR SPECIAL SURGERY

PHR: PROJECT NARRATIVE Disc degeneration and associated pain is a cause of physical and emotional distress, often leading to substantial financial burdens, due to missed work days and lost wages, but the current treatments are palliative, and do not address the underlying cause. Understanding the molecular and cellular mechanisms associated with aging and degeneration will help in the development of therapeutic approaches for treatment. This proposal aims to fill this gap in the knowledge, with the focus on understanding the role of crucial developmental molecules in postnatal disc maintenance, and their potential for therapeutic use in reversing degenerative changes in the disc.

PI_NAMEs: DAHIA, CHITRA L (contact)

PROGRAM_OFFICER_NAME: PINTUCCI, GIUSEPPE

PROJECT_TERMS: Absenteeism at work;Acceleration;Adult;Affect;Age;Age Months;age related decline;Aging;aging process;aging reversal;Agonist;Alleles;Appearance;Back Pain;Biological Assay;Brachyury protein;cartilaginous;Cell Count;Cell Differentiation process;Cell Proliferation;Cells;Chondrocyte-like Cell;Chondrocytes;Chronic low back pain;Chronology;conditional knockout;Data;Development;differential expression;Differentiation and Growth;DISC components;Disease;effective therapy;Embryo;emotional distress;Epiphysial cartilage;Exhibits;Extracellular Matrix;Financial Hardship;Gene Expression;Genes;Genetic;Genetic Transcription;Goals;Growth;Health;Heterogeneity;Human;In Vitro;in vivo;Individual;Injury;insight;Intervertebral disc structure;intervertebral disk degeneration;knock-down;Knock-out;Knowledge;Learning;Maintenance;Microscopic;Modeling;Molecular;mouse model;Mus;neonatal mice;notochord;novel;nucleus pulposus;old mice;overexpression;Pain;Palliative Care;Pathologic;Pathology;Phenotype;Population;Population Heterogeneity;postnatal;postnatal development;prevent;Process;Reporter;Research;Risk Factors;Role;SHH gene;Signal Transduction;small molecule;smoothened signaling pathway;spine bone structure;Structure;Testing;Therapeutic;therapeutic development;Therapeutic Uses;Time;transcription factor;transcriptome;transcriptome sequencing;translational study;Visualization;Wages

PROJECT_TITLE: Role of Shh/Brachyury axis in the maintenance of the postnatal intervertebral disc

STUDY_SECTION: SBSR

STUDY_SECTION_NAME: Skeletal Biology Structure and Regeneration Study Section[SBSR]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Depression;Mental Health;Mental Illness;Neurosciences;Pediatric;Prevention;Serious Mental Illness;Social Determinants of Health;Suicide;Suicide Prevention;Violence Research;Youth Violence;Youth Violence Prevention

PHR: Project Narrative Rates of suicide in youth have tripled in recent years, and although suicidality has been identified as early as the preschool period, little is known about the early emergence or development of suicidal thoughts and behaviors. This study will investigate how suicidal thoughts and behaviors are expressed in 4- to 7-year-old children alongside key correlates of suicidality (e.g., optimism, social functioning) at this early developmental point. The results will provide immediate clinical guidance regarding normative and non-normative expressions of suicidality in early childhood and will inform targeted preventive intervention efforts.

PI_NAMEs: HENNEFIELD, LAURA  (contact)

PROGRAM_OFFICER_NAME: BECHTHOLT, ANITA JEAN

PROJECT_TERMS: 6 year old;7 year old;Address;Adolescent;Adult;Age;Area;Behavior;Behavioral;bullying;Cessation of life;Child;Childhood;Choking;Clinical;Cognitive;Conceptions;conflict resolution;Data;Depressed mood;depressive symptoms;Development;Diagnostic;diagnostic biomarker;early childhood;early onset;Electroencephalography;Emotional;Environment;EP300 gene;Event-Related Potentials;Exhibits;expectation;Family Violence;Feeling hopeless;Feeling suicidal;Future;Impairment;Interview;Life;Link;Measures;Mental Depression;Mental disorders;Mentors;Meta-Analysis;modifiable risk;mortality;Motivation;multidisciplinary;National Institute of Mental Health;neural;Neurosciences;novel;novel strategies;Nursery Schools;Occupations;optimism;Outcome;P300 Event-Related Potentials;Parents;Pathway interactions;peer;peer victimization;Play;Prevention;preventive intervention;Process;programs;Psychopathology;Public Health;Race;racial diversity;Recording of previous events;recruit;Reporting;Research;Research Activity;Research Design;Research Priority;resilience;response;Risk;Risk Factors;Risk Marker;Role;School-Age Population;Science;Severities;social;social culture;Social Functioning;social relationships;socioeconomics;Specificity;Stimulus;suicidal;suicidal behavior;suicidal risk;Suicide;Suicide attempt;suicide rate;Symptoms;Techniques;theories;Training;Training Activity;Victimization;Violence;violence exposure;Withdrawal;Work;Youth

PROJECT_TITLE: Suicidality in Young Children: Social and Cognitive Developmental Markers of Risk and Resiliency

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


NIH_SPENDING_CATS: Behavioral and Social Science;Biotechnology;Brain Disorders;Data Science;Drug Abuse (NIDA only);Genetics;Neurosciences;Opioid Misuse and Addiction;Opioids;Prescription Drug Misuse;Substance Misuse

ORG_CITY: CHARLESTON

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: Project Narrative The United States is in the midst of an opioid epidemic, and many opioid addicts use oxycodone as their first narcotic analgesic. Here, we use cutting-edge neurobiological techniques in order to examine neuroadaptations underlying relapse to oxycodone seeking, with the goal of identifying novel pharmacotherapeutic targets for efficacious prevention of relapse. The experiments proposed herein have substantial promise for advancing our understanding of the brain, and as a potential treatment for addiction and other neuropsychiatric disorders in humans.

PI_NAMEs: SMITH, ALEXANDER WANLESS (contact)

PROGRAM_OFFICER_NAME: LIN, YU

PROJECT_TERMS: Abstinence;abuse liability;addiction;Adherence;Affect;Agonist;Analgesics;Animals;Area;Atlases;Behavior;Big Data;Bioinformatics;Biological;Brain;brain circuitry;Brain region;career;Cells;Clinical;Corpus striatum structure;Cues;Data;Data Analyses;Data Set;designer receptors exclusively activated by designer drugs;Detection;Development;Disease;Dopamine;efficacy evaluation;Epidemic;experience;experimental study;Extinction;FDA approved;Fluorescence-Activated Cell Sorting;FOS gene;Gene Expression;Gene Targeting;Genes;Genetic;Genetic Recombination;Glutamates;Goals;Human;Immediate-Early Genes;Immunohistochemistry;Intake;Knowledge;large datasets;Lipids;Mentors;Messenger RNA;Methods;Molecular;Molecular Biology;mouse model;Mus;Narcotic Analgesics;Nature;neural circuit;neuroadaptation;Neuroanatomy;Neurobiology;Neurons;neuropsychiatric disorder;non-opioid analgesic;novel;novel therapeutics;Opiate Addiction;Opioid;opioid abuse;opioid epidemic;opioid overdose;Opioid Receptor;Oxycodone;oxycodone seeking;oxycodone self-administration;Persons;Pharmaceutical Preparations;pharmacologic;Phase;Population;Prevention;programs;Property;protein expression;Proteins;Publishing;Pythons;Rattus;Relapse;relapse prevention;Replacement Therapy;Reproducibility;Research;Research Personnel;Resources;response;Reverse Transcriptase Polymerase Chain Reaction;Self Administration;Site;Structure;System;Techniques;Testing;Therapeutic;Tissues;Training;transcriptome sequencing;transcriptomics;Translating;translational potential;Translational Research;United States;Vulnerable Populations;Western Blotting

PROJECT_TITLE: Discovery of novel pharmacotherapeutic targets for opioid addiction


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE Alzheimer’s disease (AD) is the only disease of the top ten leading causes of death worldwide that we cannot prevent, cure, or significantly slow disease progression. The goal of this project is to establish biased signaling of the G protein-coupled receptor (GPCR) GPR3 as an alternative and viable therapeutic target for AD that modulates both amyloid-β (Aβ) pathology and the innate immune response in AD. We will test the hypothesis that biased GPR3 signaling in microglia, astrocytes, and neurons reduces AD-related pathologies and cognitive decline by promoting protective immune responses and preserving neuronal function in in vitro human glial and neuronal models and in vivo in AD murine models.

PI_NAMEs: THATHIAH, AMANTHA  (contact)

PROGRAM_OFFICER_NAME: LI, TONG

PROJECT_TERMS: abeta accumulation;Abeta clearance;Affect;Alzheimer's Disease;Alzheimer's disease patient;Amyloid beta-Protein;Area;Astrocytes;Behavioral;beta amyloid pathology;beta-arrestin;Brain;Cause of Death;Cell model;Cell Separation;cell type;Cells;chemokine;Cognition;Cognitive;Complex;cytokine;Data;Dendritic Spines;Development;Disease;Disease Progression;drug development;Exhibits;Funding;G protein coupled receptor kinase;G Protein-Coupled Receptor Signaling;G-Protein-Coupled Receptors;gamma secretase;glutamatergic signaling;Glutamates;Goals;GPR3 gene;GTP-Binding Proteins;Health;Homeostasis;Human;Hypertrophy;Immune response;Impaired cognition;In Vitro;in vivo;Induced Neurons;Innate Immune Response;knock-down;Knock-in Mouse;Ligands;Link;Mediating;Microglia;Modeling;Molecular and Cellular Biology;mouse model;Mus;neuroinflammation;Neuronal Dysfunction;Neurons;neurotrophic factor;Oligodendroglia;paracrine;Pathogenesis;Pathologic;Pathology;Pathway interactions;Patients;Phagocytosis;Pharmacologic Actions;Play;postsynaptic;pre-clinical;preservation;prevent;Public Health;Reaction;Research;response;Role;Senile Plaques;side effect;Signal Pathway;Signal Transduction;Synapses;synaptic function;Synaptic Transmission;targeted treatment;tau Proteins;Testing;Therapeutic;therapeutic target;transcriptome;TREM2 gene;Up-Regulation

PROJECT_TITLE: Cell-type-specific functions of GPR3 in Alzheimer’s disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 AN-Z (55)]


NIH_SPENDING_CATS: Behavioral and Social Science;Bipolar Disorder;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Depression;Mental Health;Mental Illness;Neurosciences;Serious Mental Illness;Sleep Research

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE Circadian rhythm disruption is common in bipolar disorder and highly predictive of a poorer clinical course. This study will test the effects of an established intervention which normalizes circadian rhythm disruption (low-dose afternoon melatonin plus time in bed scheduling) on the novel mechanistic biomarker probe of dim light melatonin onset (the gold-standard measure for circadian timing), depression, and other circadian and sleep mechanisms. Findings from the study will inform treatment targets and strategic therapies to reduce the major burden of bipolar disorder.

PI_NAMEs: SPERRY, SARAH HAVENS;SWANSON, LESLIE M (contact)

PROGRAM_OFFICER_NAME: SABBAGH, JONATHAN JACOB

PROJECT_TERMS: Academy;actigraphy;Acute;Address;Adult;American;Arousal and Regulatory Systems;Beds;Biological Markers;Bipolar Disorder;circadian;Circadian Dysregulation;circadian regulation;Circadian Rhythms;Clinical;Clinical Practice Guideline;Clinical Trials;clinically significant;cohort;Data;depressive symptoms;diagnostic criteria;Disabilities experience;disabled;Disease;Dose;Ecological momentary assessment;Education;efficacious treatment;experience;Functional impairment;General Population;Health;Home;Hour;Impairment;improved;improved outcome;improvement on sleep;Intervention;Life Expectancy;Light;Link;Longitudinal Studies;Manic;Measures;Medicine;Melatonin;Mental Depression;Metabolic;Moods;National Institute of Mental Health;novel;novel marker;Outcome;Patient Self-Report;Patients;Persons;Phase;Phototherapy;pill;placebo controlled study;Placebos;preference;prospective;Prospective Studies;Questionnaires;Randomized, Controlled Trials;Recommendation;Relapse;Reporting;Research;Research Domain Criteria;Risk;Schedule;side effect;Sleep;sleep health;sleep onset;sleep pattern;sleep regulation;social;standard measure;Symptoms;System;Testing;Time;treatment guidelines;Unipolar Depression;Work;Wrist

PROJECT_TITLE: Correcting Circadian Rhythms in Bipolar Disorder: Uncovering Mechanisms

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences

ORG_CITY: PHILADELPHIA

PHR: Project Narrative This project aims to develop a scalable and transformative technology for spatial co-profiling of epigenome, transcriptome, and a panel of proteins in the same tissue section, and deploy the high-resolution, high-content and high-throughput spatial multi-omics technologies to construct comprehensive maps of molecular and cellular events, and the associated environments underlying the etiology of Alzheimer’s disease as opposed to normal aging. It will improve our understanding of the relationship between tissue organization, function, and gene regulatory networks in AD.

PI_NAMEs: DENG, YANXIANG  (contact)

PROGRAM_OFFICER_NAME: GRAY, ERIN EMILY

PROJECT_TERMS: Adopted;Affect;Aging;aging brain;aging related disease;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer’s disease biomarker;Atlases;Bar Codes;Biological Markers;Biological Process;brain tissue;Cell Communication;Cell Nucleus;cell type;Cells;Censuses;chromatin modification;Complex;Coupled;Data;Development;Disease;Disease Progression;Environment;Epigenetic Process;epigenomic profiling;Etiology;Event;Gene Expression;gene regulatory network;Genetic Transcription;genome-wide;Grant;Health;healthspan;Heterogeneity;Hippocampus;histological stains;histone modification;Human;human disease;human imaging;human tissue;Image;improved;In Situ;insight;Knowledge;life span;Maps;Measures;Mediating;Memory impairment;Messenger RNA;Molecular;Molecular Profiling;Molecular Target;Motivation;multimodality;multiple omics;Neighborhoods;Neurofibrillary Tangles;new technology;normal aging;novel marker;novel therapeutic intervention;Outcome;Pathologic;Pattern;Phenotype;Process;protein expression;Proteins;Refractory;repaired;resilience;Resolution;Senile Plaques;single molecule;Spatial Distribution;tau Proteins;Technology;Testing;Tissues;tool;transcriptome;transcriptomics

PROJECT_TITLE: Spatially resolved multi-omics profiling of human hippocampus in Aging and Alzheimer's Disease

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]