ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_CITY: HONOLULU

ORG_NAME: UNIVERSITY OF HAWAII AT MANOA

ORG_STATE: HI

PHR: Project Narrative This project seeks to advance understanding of the origin of male infertility. The mouse zinc finger proteins ZFY1 and ZFY2 are putative transcription factors that are required for proper spermatogenesis, but their biochemical function is unknown. To address this gap in knowledge we will determine which reproduction-related genes are regulated by ZFY and the mechanism by which this regulation occurs.

PI_NAMEs: HOLMLUND, HAYDEN ROBERT (contact)

PROGRAM_OFFICER_NAME: KENT, TRAVIS JOHN

PROJECT_TERMS: Address;Amino Acid Sequence;Antibodies;assisted reproduction;Award;Binding;Biochemical;Biological Assay;C-terminal;candidate identification;Cell Separation;cell type;chromatin immunoprecipitation;Clinical;Collaborations;CRISPR/Cas technology;Cultured Cells;Defect;Detection;Development;experience;experimental study;F Factor;Fellowship;Fertility;Fertilization in Vitro;Fluorescence-Activated Cell Sorting;gene function;Genes;Genetic;genome editing;genome-wide;Germ Cells;Haploidy;Homologous Gene;Human;Immunoprecipitation;improved;in vitro Assay;Infertility;insight;Investigation;Japan;Knock-in Mouse;Knock-out;Knockout Mice;Knowledge;Link;Liquid Chromatography;male;male fertility;Male Infertility;Mass Spectrum Analysis;Meiosis;Metaphase;Methods;Molecular;Morphogenesis;mouse model;Mus;Nucleic Acid Regulatory Sequences;Outcome;Pachytene Stage;Paper;Pathway interactions;Play;Production;protein aminoacid sequence;Protein Isoforms;Proteins;Proteome;Publishing;Quality Control;Regulation;Reporter;Reproduction;reproductive;RNA;Role;sperm cell;sperm function;Spermatids;Spermatocytes;Spermatogenesis;Spermatogenic Cell;Spermiogenesis;Tail;tandem mass spectrometry;Testing;Testis;Time;Training;Transcript;transcription factor;transcriptome;transcriptome sequencing;Transgenes;Transgenic Organisms;Variant;visiting scholar;ward;Y Chromosome;ZFY protein;Zinc Fingers;zygote

PROJECT_TITLE: Identifying the Molecular Function of the Y-linked Mouse Zinc Finger Proteins ZFY1 and ZFY2

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F06-L(20)L]


ADMINISTERING_IC: DE

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Clinical Research;Dental, Oral, and Craniofacial Disease;Infectious Diseases;Microbiome

ORG_CITY: AMHERST

ORG_COUNTRY: UNITED STATES

ORG_DEPT: DENTISTRY

ORG_FIPS: US

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

ORG_STATE: NY

PHR: PROJECT NARRATIVE This project proposes the creation of a training program at the University of the West Indies in Jamaica, in collaboration with the University at Buffalo and Rush University, to build necessary research capacity to study the chronic non-communicable disease periodontitis and its association with cardiovascular disease and diabetes.

PI_NAMEs: BROWN, PAUL DEAN;DIAZ, PATRICIA  (contact);LANDAY, ALAN L

PROGRAM_OFFICER_NAME: THIRUMANGALATHU, SHOBA

PROJECT_TERMS: Address;Adolescent;Adult;Affect;Basic Science;Behavioral;Bioinformatics;Cardiometabolic Disease;cardiometabolism;Caribbean region;Child;Chronic;Chronic Disease;Clinical;clinical training;cohort;Collaborations;comorbidity;Data Science;Dental;Dentists;Development Plans;Doctor of Philosophy;Educational Curriculum;Enrollment;Epidemiologist;Epidemiology;experience;Faculty;faculty mentor;Fellowship;Foundations;Functional disorder;Future;graduate student;Health;human subject;Immune response;Immunology;innovation;Interdisciplinary Study;Intervention;Jamaica;Jamaican;Knowledge;Laboratories;Medical;Medical Faculty;Mentors;microbiome;microbiome research;multidisciplinary;next generation;Oral;Oral health;Periodontal Diseases;Periodontitis;Postdoctoral Fellow;pre-doctoral;programs;Research;Research Activity;research and development;Research Personnel;response;School Dentistry;Science;Scientist;social;Systemic disease;Training;Training Programs;translational medicine;Universities;West Indies

PROJECT_TITLE: Building Research Capacity to Study Periodontitis and Associated Systemic Comorbidities in the Caribbean


ADMINISTERING_IC: VA

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: Veterans Affairs

ORG_CITY: SAN DIEGO

ORG_NAME: VA SAN DIEGO HEALTHCARE SYSTEM

ORG_STATE: CA

PHR: Cutaneous T cell Lymphoma (CTCL) is an indolent but life-threatening cancer of T lymphocytes that reside in the skin. One recent study using the VA Informatics and Computing database estimated a 6-8 fold higher incidence among Veterans than the general population. Although prognosis worsens with increasing disease stage, CTCL patients of all stages suffer from chronic skin inflammation that can produce unsightly or disfiguring skin lesions, itching, pain, and sleep disturbance that interfere with daily activities, and cause emotional distress. CTCL are often misdiagnosed as benign skin conditions, delaying appropriate therapies. The goal of the proposed studies is to have a positive effect on the health of Veterans by (1) identifying epigenetic and gene expression biomarkers that can improve diagnostic specificity in early disease, (2) increasing understanding of genetic dysregulation that promotes CTCL pathogenesis, and (3) overcoming barriers to progress in studies of skin-derived T cells.

PI_NAMEs: WONG, HENRY KEUNG (contact)

PROJECT_TERMS: Address;advanced disease;Affect;Benign;Binding Sites;Biological;Biological Assay;Biological Markers;biomarker identification;cancer cell;cancer genome;cell growth;Chemicals;Chronic;Clinical;combat;Complex;Cross-Sectional Studies;Cutaneous T-cell lymphoma;Data;Databases;demethylation;Development;Diagnosis;diagnostic biomarker;Diagnostic Specificity;Diagnostic tests;diagnostic value;differential expression;Disease;Disease Progression;DNA;DNA analysis;DNA Methylation;Early Diagnosis;Eczema;effective therapy;emotional distress;Enhancers;Enzymes;Epigenetic Process;epigenetic regulation;Etiology;Evolution;Experimental Models;experimental study;Exposure to;gain of function;Gene Abnormality;Gene Expression;Gene Expression Profiling;General Population;Genes;Genetic;Genetic Heterogeneity;Genetic Markers;genome-wide;Genomic Instability;Genomics;Goals;Grant;Health;Hydrocarbons;Hypermethylation;improved;Incidence;Indolent;Inflammation;Inflammatory;Informatics;insight;leukemia;Life;loss of function;Malignant - descriptor;Malignant Neoplasms;Maps;Methylation;methylation biomarker;methylome;Military Personnel;military veteran;Monitor;mRNA Expression;Mutation;Mycosis Fungoides;Nature;neoplastic;Neoplastic Cell Transformation;new therapeutic target;novel;Occupational;Oncogenic;overexpression;Pain;Pathogenesis;Pathogenicity;Pathway interactions;Patients;permissiveness;personalized medicine;Pesticides;prevent;Process;Prognosis;Prognostic Marker;promoter;Pruritus;Psoriasis;Publishing;Quality of life;Regulatory Element;Repression;Reproducibility;Research;Resolution;Rest;Risk;Risk Factors;Role;Services;Severity of illness;Sezary Syndrome;Signal Transduction;Site;Skin;skin lesion;Sleep disturbances;Study models;T-Cell Activation;T-Cell Lymphoma;T-Lymphocyte;Technology;Training;transcription factor;transcriptome;transcriptome sequencing;treatment strategy;tumor;Tumor Suppressor Genes;tumorigenesis;TWIST1 gene;Variant;Veterans

PROJECT_TITLE: Epigenetic Regulation of Differentially Expressed Genes in Cutaneous T Cell Lymphoma


ORG_CITY: ANN ARBOR

ORG_NAME: VETERANS HEALTH ADMINISTRATION

ORG_STATE: MI

PHR: Multidrug-resistant organisms (MDROs) are endemic in both acute care settings and nursing homes (NHs). With this project, we plan to develop a deeper understanding of the role of patient colonization with all MDROs - immediate and distant - in environmental contamination, role of health care professional hand colonization, transmission during their NH stay and out-of-room visits and colonization upon discharge. A clearer understanding of these relationships will inform development of targeted interventions to reduce patient colonization and environmental contamination, prevent MDRO transmission and infections, and enhance the safety of care for older Veterans. We expect our results to have widespread application within and outside Veterans Affairs (VA) settings, enhance residents’ quality of life, and shift the evolving paradigm of MDRO transmission.

PI_NAMEs: MODY, LONA  (contact)

PROJECT_TERMS: acute care;Aging;Antibiotic Resistance;Area;Bacillus;Biological;Biopsy;Caregivers;Caring;CLC Gene;Clinic;Clinical;Clinical Data;clinical diagnostics;Communicable Diseases;community living;comorbidity;Day Surgery;design;Development;Dialysis procedure;disability;Discipline of Nuclear Medicine;Discipline of Nursing;Distant;Ecology;Education;Environment;Environmental Pollution;Epidemiology;Evaluation;Family;Fingerprint;Focus Groups;Future;genomic data;genomic epidemiology;Genomics;Goals;Hand;Health;Health behavior;Health Professional;Health Service Area;Healthcare Systems;high risk;Hospitals;Hygiene;improved;indexing;Individual;Infection;Infection prevention;Infusion procedures;innovation;Institution;Intensive Care Units;Intervention;intervention mapping;Knowledge;Leadership;Medical;medical appointment;methicillin resistant Staphylococcus aureus;Methods;Microbiology;Molecular;Molecular Epidemiology;Movement;multi-component intervention;multi-drug resistant pathogen;multidisciplinary;nursing home length of stay;Nursing Homes;Occupational Therapy;older adult;Operative Surgical Procedures;Organism;Outcome;Participant;patient oriented research;Patients;Patients' Rooms;Pattern;Physical therapy;Population;Positioning Attribute;Pre-Post Tests;Prevalence;prevent;Prevention;Prevention education;Prevention strategy;Procedures;Prospective, cohort study;Provider;Qualitative Research;Quality of life;Radiology Specialty;Recreation;Rehabilitation therapy;Research Design;Role;Safety;Saints;Science;Services;Spinal Cord;Staphylococcus aureus infection;statistics;success;Surface;therapy design;therapy development;Time;translational study;transmission process;United States Department of Veterans Affairs;Vancomycin resistant enterococcus;Veterans;Visit;ward

PROJECT_TITLE: Patient Movement and Impact on Multidrug-Resistant Organism (MDRO) Transmission


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: DURHAM

ORG_DEPT: SURGERY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE – Overall The Duke Center for AIDS Research (CFAR) provides comprehensive infrastructure support to basic, translational, and clinical investigators conducting HIV/AIDS research. Maintaining strategic alignment with the National CFAR Mission Statement and the NIH Strategic Plan for HIV and HIV-Related Research, Duke CFAR will continue to advance toward our goals of HIV prevention and improving outcomes for people with HIV/AIDS.

PI_NAMEs: NAGGIE, SUSANNA ;TOMARAS, GEORGIA DORIS (contact)

PROGRAM_OFFICER_NAME: WONG, ELAINE WAI-KEN

PROJECT_TERMS: Acceleration;Acquired Immunodeficiency Syndrome;Address;Advisory Committees;AIDS prevention;Area;base;Basic Science;Censuses;Clinical;Clinical Investigator;co-infection;Collaborations;Communication;Communities;community engagement;Community Outreach;comorbidity;Development;diversity and inclusion;driving force;Education;Emerging infection;Ensure;Environment;Epidemic;Equity;Evolution;Faculty Recruitment;Fortification;Fostering;Foundations;Funding;gender diversity;Goals;Grant;Growth;health disparity;HIV;HIV/AIDS;improved outcome;Individual;Infrastructure;innovation;Institution;Investments;Lead;Leadership;medical schools;member;Mental Health;Mentors;Mentorship;Methodology;Mission;next generation;NIH Office of AIDS Research;Operative Surgical Procedures;opioid epidemic;Organ;outreach program;Persons;Policies;Prevention;Prevention Research;Process;programs;Qualifying;racial diversity;recruit;Research;Research Personnel;Research Priority;Research Support;Resource-limited setting;Resources;Role;Services;skills;Solid;Strategic Planning;Substance abuse problem;success;synergism;Training;Translating;translational scientist;treatment research;United States National Institutes of Health;Universities;Vaccine Design;vaccine evaluation

PROJECT_TITLE: Centers for AIDS Research (CFAR)


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Drug Abuse (NIDA only);HIV/AIDS;Immunization;Infectious Diseases;Prevention;Substance Misuse;Vaccine Related;Vaccine Related - AIDS

PI_NAMEs: WEINHOLD, KENT J. (contact)

PROJECT_TERMS: Acceleration;Acquired Immunodeficiency Syndrome;Address;Administrative Coordination;Administrator;Advisory Committees;Affect;AIDS prevention;Area;Award;Behavioral Sciences;Budgets;Chalk;Charge;Clinical;Collaborations;Communicable Diseases;Communication;Communities;community advisory board;Community Outreach;cost efficient;design;Development;Discipline of Nursing;distinguished professor;Doctor of Philosophy;Education;Educational workshop;Electronic Mail;Ensure;Epidemic;Evaluation;Expenditure;experience;Extramural Activities;Faith-based organization;Financial Support;Funding;global health;Goals;Grant;HIV;HIV/AIDS;Home;Human;human subject;Immunology;improved;improved outcome;Information Dissemination;Infrastructure;innovation;Institution;Institutional Policy;International;Leadership;Medical center;Medicine;meetings;member;Mentors;Mission;Needs Assessment;Newsletter;Occupational activity of managing finances;Operative Surgical Procedures;outreach;Outreach Research;Pathology;Patient-Focused Outcomes;Peer Review;Periodicals;Pilot Projects;Policies;Prevention;Procedures;Process;Productivity;professor;programs;Progress Reports;Qualifying;Regulation;Reporting;Research;Research Activity;Research Personnel;Resources;response;Science;Scientist;Services;Social Sciences;Strategic Planning;Surveys;symposium;System;Tanzania;Testing;United States National Institutes of Health;Vertebrates;web site;Woman;Work;working group;Writing

PROJECT_TITLE: Administrative Core


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Clinical Research;Emergency Care;Heart Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: Columbus

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative Out-of-hospital cardiac arrest (OHCA) is a major public health problem annually affecting close to half a million people in the US. As survival is only at 10%, new interventions that reflect the dynamic process during resuscitation are needed to improve outcomes. This proposal will define real-time physiologic dynamics in relation to patient specific characteristics and resuscitation interventions to develop new artificial intelligent driven resuscitation algorithms.

PI_NAMEs: NASSAL, MICHELLE M.J. (contact)

PROGRAM_OFFICER_NAME: HUANG, LI-SHIN

PROJECT_TERMS: Adult;Affect;Algorithms;American;Artificial Intelligence;Automobile Driving;Benchmarking;Biological Markers;Biometry;Canada;Capnography;Carbon Dioxide;Cardiac;Cardiopulmonary Resuscitation;Caring;Characteristics;Circulation;Classification;Collaborations;Collection;Communities;Country;Data;Data Set;Development;Disparity;Effectiveness of Interventions;Emergency medical service;Epinephrine;Equity;ethnic bias;Ethnic Origin;Etiology;experience;Feedback;Foundations;Functional disorder;Future;Gender;Goals;Grant;Healthcare;Heart Arrest;heart rhythm;Hospitals;human data;Hypoventilation;improved;improved outcome;Individual;individual patient;individualized medicine;innovation;insight;International;Intervention;Machine Learning;machine learning method;Measurement;Measures;Medical center;Medicine;Mentors;Modeling;multimodal learning;novel;Ohio;out-of-hospital cardiac arrest;Outcome;Patient Care;Patients;Perfusion;personalized approach;Persons;Pharmaceutical Preparations;Physicians;Physiological;Physiology;Process;Public Health;Race;racial bias;repository;Research;Research Personnel;Resuscitation;Scientist;Sex Bias;signal processing;simulation;skills;Solid;Spain;success;Technology;Testing;Texas;Time;time interval;tool;Training;Training Programs;Universities;Variant;ventilation;Work

PROJECT_TITLE: Artificial Intelligence for Dynamic, individualized CPR guidance: AID CPR

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(JA)]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunization;Infectious Diseases;Opioid Misuse and Addiction;Opioids;Prevention;Substance Misuse;Vaccine Related;Vaccine Related - AIDS

PI_NAMEs: STAATS, HERMAN F (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Applications Grants;Area;Attention;Award;career development;career networking;Communities;comorbidity;Complement;Data;Development;Ensure;Environment;Epidemic;Faculty;Faculty Recruitment;faculty support;Feedback;Financial Support;Fostering;Funding;Funding Mechanisms;Generations;Goals;Grant;Grant Review;Growth;Health;health inequalities;Health Services Accessibility;Heart;Hepatitis C;HIV;HIV-1;HIV/AIDS;implementation science;improved;Infection;Institution;Interdisciplinary Study;Manuscripts;medical schools;member;Mentors;Methods;Mission;multidisciplinary;next generation;Opiate Addiction;opioid use disorder;Outcome;Peer Review;Persons;Pilot Projects;Populations at Risk;prevent;Productivity;programs;Public Health;Publications;recruit;Reduce health disparities;Research;research faculty;Research Personnel;Research Priority;Research Project Grants;Resources;Services;skills;Structure;success;synergism;Training;Underrepresented Minority;United States;United States National Institutes of Health;Work;working group

PROJECT_TITLE: Developmental Core


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Drug Abuse (NIDA only);HIV/AIDS;Immunization;Infectious Diseases;Prevention;Substance Misuse;Vaccine Related

PI_NAMEs: TOMARAS, GEORGIA DORIS (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Algorithms;Antibodies;antibody test;Antigen-Antibody Complex;Area;assay development;Avidity;Award;B cell repertoire;B-Lymphocytes;Basic Science;Binding;Biological Assay;career development;Cell Separation;Cells;Cellular Assay;Cellular Immunology;Charge;Clinical;co-infection;Collaborations;Communities;comorbidity;Complement Activation;Consultations;Core Facility;Country;Data;Data Analyses;data integrity;Detection;Development;Drug Kinetics;Education;Educational workshop;Effector Cell;Emerging infection;Ensure;Epidemic;Epitope Mapping;Equity;Fc Receptor;Flow Cytometry;flu;Fostering;Gene Expression Profiling;Goals;health disparity;HIV;HIV Infections;HIV Vaccine Trials Network;HIV-1;HIV/AIDS;Human;Immune;Immunogenomics;Immunologic Monitoring;Immunologics;Immunology;Immunology procedure;Infection;innovation;Institution;International;International Maternal Pediatric Adolescent AIDS Clinical Trials;Investments;Laboratories;Lead;Malaria;Measurement;Mediating;Mental Health;Mentors;Mentorship;Methodology;Methods;Microscopy;Mission;Monitoring Clinical Trials;Monoclonal Antibodies;monocyte;Mucous Membrane;neutralizing antibody;neutrophil;novel;Organ;Performance;Pharmaceutical Preparations;Phase;Phenotype;Policies;Prevention;Prophylactic treatment;protein structure;Publications;quality assurance;Quality Control;receptor binding;Recording of previous events;Research;Research Personnel;Research Priority;Research Training;Resource-limited setting;response;Science;Scientist;Services;Specificity;Standardization;structural biology;Substance abuse problem;System;T-Lymphocyte;Technology;tool;Training;Translating;Typhoid Fever;United States National Institutes of Health;Vaccination;Vaccine Design;vaccine evaluation;Vaccines;Virion;virology;Virus;Work

PROJECT_TITLE: Immunology Core (Basic Science Core)


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Data Science;Dental, Oral, and Craniofacial Disease;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Networking and Information Technology R&D (NITRD);Prevention;Substance Misuse

PI_NAMEs: CHAN, CLIBURN C (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Applications Grants;Area;Big Data;Big Data Methods;Bioinformatics;Biological Assay;Biology;Biometry;Biostatistics Core;Chalk;Charge;Child Development;Child Health;Clinic;Clinical;Clinical Sciences;Clinical Trials Design;Collaborations;Communication;Communities;Competence;Complex;complex data;Computational Biology;computer science;Computer software;Consultations;Coordination and Collaboration;Core Facility;Data;Data Analyses;data cleaning;data management;Data Provenance;Data Science;Data Set;design;Development;Discipline;Education;education research;Educational workshop;Effectiveness;Electronic Health Record;Ensure;Environment;Experimental Designs;Faculty;faculty mentor;Fostering;Foundations;Funding;Genomics;global health;graduate student;Grant;Health;HIV;HIV/AIDS;Immunology;improved;Individual;informatics tool;Infrastructure;innovation;Internships;Joints;laboratory experience;Link;Malignant Neoplasms;Manuscripts;mathematical sciences;meetings;member;Mental Health;Mentors;method development;Methodology;Methods;microbial;microbiome;Mission;Modeling;Names;National Institute of Allergy and Infectious Disease;North Carolina;novel;Outcome;Participant;Patients;Pharmacogenomics;population health;Pragmatic clinical trial;Preparation;Principal Investigator;Productivity;programs;Publications;Reproducibility;Research;Research Institute;Research Personnel;Research Support;Resources;Science;Services;skills;South Carolina;Statistical Data Interpretation;Statistical Methods;statistics;Substance abuse problem;success;summer internship;Techniques;Thinking;tool;Training;Training and Education;Translational Research;United States National Institutes of Health;Universities;Vertical Transmission;Visualization;Walking;Work;working group

PROJECT_TITLE: Quantitative Sciences Core


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Prevention;Substance Misuse

PI_NAMEs: BARTLETT, JOHN A (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Acute;acute care;Address;Applications Grants;Archives;Behavioral Sciences;biobank;Biological;Biological Specimen Banks;Cardiovascular Diseases;Cardiovascular system;Caring;Characteristics;Clinic;Clinical;cohort;Collaborations;Communities;community advisory board;community collaboration;community engagement;community planning;comorbidity;Computerized Medical Record;Consultations;Databases;design;Development;Disease;Early treatment;Enrollment;Epidemic;Ethics;experience;Faculty;Focus Groups;Funding;Grant Review;health care disparity;Health Professional;Health Services Research;Health system;Hepatic;Historically Black Colleges and Universities;HIV;HIV Infections;HIV Vaccine Trials Network;HIV/AIDS;Human immunodeficiency virus test;improved;Infection prevention;Injecting drug user;insight;Institution;interdisciplinary collaboration;International;Intervention;Investigation;Kenya;Kidney;Leadership;Link;Malignant - descriptor;marginalized population;Mentors;Mentorship;next generation;outreach;patient oriented;Patient Recruitments;Patients;Persons;Phenotype;Play;Population;pre-exposure prophylaxis;Prevention;Public Health;recruit;repository;Research;Research Activity;Research Design;Research Personnel;Research Priority;Research Training;response;Role;Science;Services;Site;Social Behavior;Social Sciences;sound;South Africa;Specific qualifier value;Specimen;Substance abuse problem;success;Tanzania;Training;United States National Institutes of Health;Universities;Vaccines;Work;working group

PROJECT_TITLE: Clinical Core


ORG_CITY: NEW YORK

ORG_NAME: NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC

PHR: PROJECT NARRATIVE The Columbia Psychiatry, Psychology, and Public Health Collaborative LD Innovation Hub aims to provide evidence of novel environmentally-associated profiles of learning difficulties in Black and Latinx children and adolescents from economically disadvantaged families. Relating prenatal exposures to chemical neurotoxicants like air pollution, as is proposed in the embedded research of the Hub, will help close the achievement gap in the United States by identifying brain and behavior pathways from exposure to learning problems in children from economically disadvantaged families. This information can then be used in future studies to develop novel interventions for academic skills deficits in this population of children and to develop exposure prevention programs that use public health messaging to improve children's health and development.

PI_NAMEs: MARGOLIS, AMY  (contact);RAUH, VIRGINIA A

PROGRAM_OFFICER_NAME: MILLER, BRETT

PROJECT_TERMS: Academia;Academic achievement;academic intervention;Academic skills;Achievement;Address;Adolescent;Air Pollution;Animal Model;Aromatic Polycyclic Hydrocarbons;base;Behavior;Behavioral;Birth;Black race;Brain;career;Chemicals;Child;Child Health;Child Psychiatry;Cognitive;cognitive neuroscience;cognitive process;cohort;Communication;Complex;Corpus striatum structure;Data;Development;Dimensions;Disability research;disadvantaged background;Disparity;Dopamine;early life stress;economic disparity;Economics;Education;Environment;environmental chemical exposure;Environmental Exposure;Environmental Health;Environmental Risk Factor;Environmental Science;epidemiology study;Etiology;Exclusion;experience;exposure pathway;Exposure to;Extramural Activities;Family;federal poverty level;field study;Fostering;Foundations;Functional disorder;Functional Magnetic Resonance Imaging;Future;genetic predictors;Genetic Variation;Goals;Health Sciences;high risk;Human;improved;Infrastructure;innovation;Instruction;Interdisciplinary Education;Intervention;intervention program;Knowledge;Latinx;Lead;Leadership;Learning;Learning Difficulty;Learning Disabilities;Learning Disorders;Magnetic Resonance Imaging;Mathematics;Mediating;Mentors;Mentorship;Methodology;Midbrain structure;Modeling;neural;neural circuit;Neural Pathways;Neurobiology;neuroimaging;neuromelanin;Neuropsychology;Neurosciences;Neurosciences Research;neurotoxic;Neurotoxins;next generation;novel;Outcome;Pathway interactions;Performance;Phenotype;Population;Positioning Attribute;prenatal;prenatal exposure;Prevention program;Process;programs;prospective;Psychiatry;Psychological reinforcement;Psychology;Public Health;Reading;Reading Disorder;recruit;Research;Research Personnel;Research Project Grants;Role;Sampling;Scientist;social;socioeconomic disadvantage;Source;standardize measure;Stress;stress reduction;System;Training;Training and Infrastructure;training opportunity;Translating;Translations;Underrepresented Populations;United States

PROJECT_TITLE: Environmental Contributions to Disparities in Learning Disabilities: The Columbia Psychiatry, Psychology, and Public Health Collaborative Learning Disabilities Innovation Hub


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Climate-Related Exposures and Conditions;Conditions Affecting the Embryonic and Fetal Periods;Disability Research;Endocrine Disruptors;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention;Social Determinants of Health

PI_NAMEs: MARGOLIS, AMY  (contact)

PROJECT_TERMS: Academic achievement;Academic support;Achievement;Adolescent;Affect;Age;air monitoring;Air Pollutants;Air Pollution;Animal Model;Area;Aromatic Polycyclic Hydrocarbons;Behavior;Behavioral;Biological;Birth;Black race;Brain;Budgets;Chemicals;Child;Childhood;Chronic stress;Cognitive;cognitive process;cognitive system;cohort;Communities;Complex;Computer Models;Corpus striatum structure;cost;Data;Data Collection;Development;Diffusion;Dimensions;Disability research;disadvantaged background;Disparity;Dopamine;Dorsal;early experience;Early Intervention;early life stress;economic disparity;Environment;Environmental Health;experience;exposure pathway;Exposure to;Family;federal poverty level;Functional disorder;Future;high risk;Human;imaging approach;imaging study;Impairment;improved;in vivo;information processing;Infrastructure;innovation;Instruction;Interdisciplinary Education;Intervention;intervention program;Latinx;Learning;Learning Difficulty;Learning Disabilities;learning outcome;Link;literacy;Magnetic Resonance;Magnetic Resonance Imaging;mathematical ability;Mathematics;Measurement;Measures;Mediating;Methods;Midbrain structure;neighborhood disadvantage;neural;Neural Pathways;Neurobiology;neuroimaging;neuromelanin;neuroregulation;neurotoxic;novel;Participant;Pathway interactions;Pattern;Performance;Phenotype;Pollution;Polycyclic Compounds;Prefrontal Cortex;prenatal;prenatal experience;prenatal exposure;prenatal testing;preventive intervention;prospective;Proxy;Psychiatry;psychological outcomes;Psychological reinforcement;Psychology;psychosocial stressors;Public Health;rapid growth;Reading;Research;Research Project Grants;Sampling;Science;social;Socioeconomic Status;Standardization;Stress;Substantia nigra structure;System;Testing;therapy design;Third Pregnancy Trimester;Time;Ventral Striatum;Ventral Tegmental Area;Work;Youth

PROJECT_TITLE: Effects of Prenatal Exposure to Air Pollution and Early Life Stress on Dopaminergic and Cognitive Systems and Their Contributions to Environmentally-Associated Learning Difficulties


PI_NAMEs: CORNELI, AMY LYNN (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Adherence;AIDS prevention;antiretroviral therapy;Area;Attenuated;barrier to care;Behavior Therapy;Behavioral;Behavioral Research;Behavioral Sciences;behavioral study;Biological Markers;Caring;co-infection;Collaborations;Communities;community collaboration;community partners;comorbidity;Consultations;Continuity of Patient Care;County;design;Discipline of Nursing;Disparity;disparity reduction;Dissemination and Implementation;Educational workshop;Ensure;Epidemic;Faculty;Fostering;Funding;global health;Goals;Grant;Growth;Health Sciences;Healthcare Systems;HIV;HIV Infections;HIV/AIDS;improved;Incidence;Individual;Inequity;innovation;Institution;interdisciplinary collaboration;Interdisciplinary Study;Intervention;Leadership;Link;Louisiana;Medical;Mental disorders;Mental Health;Mentors;Mentorship;Mission;Neurosciences;North Carolina;novel;novel therapeutics;Outcome;Peer Review;Population;population health;Positioning Attribute;pre-exposure prophylaxis;prevent;Prevention;programs;Psychiatry;Psychology;Research;Research Methodology;Research Personnel;Research Project Grants;Research Support;scale up;Science;Services;social;Social Sciences;social stigma;sound;Structure;Substance abuse problem;substance use;success;synergism;Technology;Testing;Training;Underrepresented Populations;United States National Institutes of Health;Universities;University resources;Veterans Health Administration;Viral;working group

PROJECT_TITLE: Social and Behavioral Sciences Core


NIH_SPENDING_CATS: Behavioral and Social Science;Disability Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurosciences;Pediatric;Social Determinants of Health

PI_NAMEs: RAUH, VIRGINIA A (contact)

PROJECT_TERMS: Administrator;Biological;career;Child;Clinic;Cognitive;Communication;Communication difficulty;Communities;community based participatory research;community engagement;Community Health Education;Community Networks;Computer Models;cost effective;Dedications;Disability research;Disparity;Dissemination and Implementation;dissemination science;economic disparity;Education;Educational Curriculum;Educational workshop;educationally disadvantaged;environmental chemical;Environmental Exposure;Epidemiology;Ethics;Etiology;Evaluation;experience;Exposure to;Faculty;Family;Feedback;Fellowship;Fostering;Funding;Future;Goals;high risk;implementation science;Incubators;Information Dissemination;Infrastructure;innovation;Joints;Leadership;Learning;Learning Difficulty;Learning Disabilities;Link;Magnetic Resonance Imaging;member;Mentorship;Mission;Modeling;Neighborhoods;neuromelanin;Neurosciences;Neurosciences Research;next generation;Pathway interactions;Performance;Policy Maker;Population;Process;programs;Psychiatry;Psychologist;Psychology;Public Health;Research;Research Methodology;Research Personnel;Research Project Grants;research study;Research Training;scaffold;Schools;Science;Scientist;Site;skills;social;sound;Specialist;success;System;teacher;Techniques;Testing;Thinking;Training;Training and Infrastructure;Training Programs;Translating;Translational Research;Underrepresented Populations;underserved community;Vision;Work

PROJECT_TITLE: The CU Learning Disabilities (LD) Leadership Core: Scaffolding a Growing Center of Environmental LD Research and The Next generation of LD Scholars


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunization;Infectious Diseases;Prevention;Racial and Ethnic Minority Health Research;Substance Misuse;Vaccine Related

PI_NAMEs: MCKELLAR, MEHRI S (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;AIDS prevention;Applications Grants;Area;black men who have sex with men;black women;Clinic;clinical research site;Clinical Trials Network;Collaborations;Communities;County;Databases;Dedications;Development;Epidemic;Event;Faculty;Fostering;Funding;Geographic Locations;Goals;Grant;Group Affiliation;HIV;HIV Infections;HIV vaccine;HIV Vaccine Trials Network;Home;Human;Incidence;Injecting drug user;innovation;Institution;interest;Joints;Latinx;Leadership;Link;member;Modality;North Carolina;novel;peer;Population;Populations at Risk;Positioning Attribute;pre-exposure prophylaxis;Prevention;Prevention Research;Prevention strategy;Research;research and development;Research Personnel;Research Proposals;research study;Research Support;response;Rural;Scientist;Services;social media;South Carolina;symposium;vaccine development;Vaccines;Vertical Transmission;web page;web site;working group

PROJECT_TITLE: Biomedical Prevention Scientific Working Group


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Immunotherapy;Infectious Diseases;Sexually Transmitted Infections

ORG_CITY: BOSTON

ORG_NAME: TUFTS MEDICAL CENTER

ORG_STATE: MA

PHR: We propose to investigate the role of plasmacytoid dendritic cells in the maintenance of corneal immune homeostasis, and their effects in dampening corneal immune responses. We will investigate the molecular mechanisms by which plasmacytoid dendritic cells have immunomodulatory effects on innate and adaptive immunity. Further, we aim to assess the therapeutic efficacy of local adoptive transfer of plasmacytoid dendritic cells or topical treatment with their secretome in ameliorating corneal inflammation in clinically relevant models of dry eye disease, herpes simplex keratitis, and allogeneic corneal transplantation.

PI_NAMEs: HAMRAH, PEDRAM  (contact)

PROGRAM_OFFICER_NAME: MCKIE, GEORGE ANN

PROJECT_TERMS: Acute;adaptive immune response;adaptive immunity;Adoptive Transfer;advanced disease;Affect;Allogenic;Anti-Inflammatory Agents;Antigen Presentation;Antigen Presentation Pathway;Antigen-Presenting Cells;Antigens;Area;Autoimmune;Bone Marrow;Candidate Disease Gene;candidate identification;Cell Communication;Cells;Chimera organism;Clinical;clinically relevant;Coculture Techniques;Communicable Diseases;Confocal Microscopy;Cornea;Corneal Diseases;Corneal Injury;Corneal Opacity;cytokine;Data;Dendritic Cells;density;Development;Disease;Disease Progression;draining lymph node;Dry Eye Syndromes;effector T cell;Endowment;Esthesia;experimental study;Feasibility Studies;Fibrin Tissue Adhesive;Gene Silencing;Generations;Grant;Herpesvirus 1;Herpetic Keratitis;Homeostasis;Immune;immune modulating agents;Immune response;Immune System Diseases;Immunity;immunoregulation;improved;in vivo;Infection;Inflammation;Inflammation Process;Inflammatory;Interferon Type II;Interleukin-10;Investigation;Keratitis;Keratoplasty;Kinetics;Label;Leucocytic infiltrate;Leukocytes;Lymphocyte;Maintenance;Measures;Mediating;Modeling;Molecular;multiphoton microscopy;Natural Immunity;Nerve;novel;novel strategies;Outcome;phenotypic biomarker;Property;protein expression;receptor;recruit;Regulatory T-Lymphocyte;Role;Severities;Severity of illness;side effect;Simplexvirus;single cell sequencing;single-cell RNA sequencing;spatiotemporal;Stains;Sterility;Surgical sutures;Survival Rate;T-Cell Proliferation;T-Lymphocyte;Tissues;TLR7 gene;TNF gene;Topical application;Transforming Growth Factor beta;Transgenic Mice;transplant model;Treatment Efficacy;uptake;Viral;Virus Diseases

PROJECT_TITLE: The role of plasmacytoid dendritic cells in corneal immunity

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 1 Study Section[PED1]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Infant Mortality;Lung;Neonatal Respiratory Distress;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn

ORG_CITY: IOWA CITY

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Project Narrative The Transfusion of Prematures (TOP) Trial randomized 1,824 preterm infants to liberal or restrictive red blood cell transfusions in order to determine which practice might be best for neurodevelopmental outcomes at 2 years. The current “TOP 5 Study” will assess functional neurodevelopmental outcomes of TOP subjects at 5 years of age, an age which will permit detailed assessment of cognitive skills, motor coordination, emotional/behavioral development, and academic readiness. Evaluating which approach to transfusion minimizes damage to vulnerable neuronal circuits is expected to have a significant impact on the clinical management of preterm infants and, in turn, improve both short and long-term outcomes for premature infants.

PI_NAMEs: CONRAD, AMY LYNN (contact);DEMAURO, SARA BONAMO

PROGRAM_OFFICER_NAME: FRANK, DANIEL J

PROJECT_TERMS: 5 year old;academic preparation;Academic skills;Age;Age Months;Assessment tool;Behavioral;Brain;Bronchopulmonary Dysplasia;Budgets;Cessation of life;Child;Child Development;Classification;Clinical;Clinical Management;Cognition;Cognitive;cognitive function;cognitive skill;cohort;Collaborations;Data Coordinating Center;design;Development;Dimensions;Emotional;Enrollment;Ensure;Erythrocyte Transfusion;experience;Exposure to;Extremely Low Birth Weight Infant;Family;follow-up;Functional impairment;functional outcomes;Funding;Future;Home environment;Hydrocortisone;Impairment;improved;Infant;infant outcome;innovation;Intensive Care Units;International;Iowa;Knowledge;Measures;Methods;Morbidity - disease rate;Motor;Motor Skills;Movement;Multicenter Neonatal Research Network;Multicenter Studies;National Heart, Lung, and Blood Institute;National Institute of Child Health and Human Development;Neonatal;Neonatology;Network Infrastructure;Neurodevelopmental Impairment;Neurological outcome;neuronal circuitry;Outcome;Outcome Measure;Outcome Study;Outcomes Research;Packed Red Blood Cell Transfusion;Pediatric Hospitals;Performance;Philadelphia;phonology;Population;premature;Premature Infant;primary outcome;Productivity;Randomized;randomized trial;Readiness;Recording of previous events;Research Infrastructure;Research Personnel;Resources;respiratory;Sample Size;school environment;School-Age Population;Schools;skills;success;System;Testing;Time;Transfusion;Universities;Work

PROJECT_TITLE: Transfusion of Prematurity Early School Age Follow-up (TOP 5) CCC

STUDY_SECTION: CLTR

STUDY_SECTION_NAME: Clinical Trials Review Study Section[CLTR(MA)]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Emergency Care;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Homicide and Legal Interventions;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Physical Injury - Accidents and Adverse Effects;Pregnancy;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Suicide;Violence Against Women;Violence Research;Women's Health Research

ORG_CITY: EAST LANSING

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: MICHIGAN STATE UNIVERSITY

PHR: PROJECT NARRATIVE This research will advance clinical and public health knowledge regarding the incidence of and trends and disparities in mortality and morbidity during pregnancy and the first year postpartum due to drug use, self-harm, and violence. Our research will also change clinical practice by finding ways to identify women – in hospital- based settings – at high risk for future morbidity and mortality due to drug use, self-harm, and violence, and lay the foundation for developing preventive strategies. The evidence from the proposed research will extend the current knowledge about maternal morbidity and mortality to encompass non-obstetric causes that are of substantial and growing importance.

PI_NAMEs: GOLDMAN-MELLOR, SIDRA ;MARGERISON, CLAIRE E (contact)

PROGRAM_OFFICER_NAME: CHINN, JUANITA JEANNE

PROJECT_TERMS: Accident and Emergency department;biomarker identification;Birth;black women;California;Cause of Death;Cessation of life;Clinical;clinical practice;Data;Data Set;Databases;Death Certificates;Demography;Development;Diagnosis;Disparity;Drug usage;ethnic disparity;experience;Foundations;Funding;Future;Goals;health disparity;health knowledge;Health Personnel;Hemorrhage;high risk;High Risk Woman;Homicide;Hospital Departments;Hospital Records;Hospitalization;Hospitals;Hypertension;improved;Incidence;Income;innovation;Interdisciplinary Study;Intervention;Knowledge;knowledge base;Life;Link;Live Birth;low socioeconomic status;Maternal Health;maternal morbidity;Maternal Mortality;Measures;Mental Health;Methods;Morbidity - disease rate;mortality;mortality disparity;Mothers;Not Hispanic or Latino;novel;Outcome;Pharmaceutical Preparations;population based;Positioning Attribute;postpartum morbidity;Postpartum Period;Postpartum Women;Pregnancy;pregnancy related death;Pregnant Women;prevent;Prevention;Prevention strategy;Provider;Psychiatric epidemiology;Public Health;public health priorities;racial disparity;Research;Risk Factors;rural area;Self-Injurious Behavior;service utilization;Services;socioeconomic disparity;substance use;Suicide;suicide mortality;Testing;Time;trend;United States;venous thromboembolism;Violence;violence victimization;White Women;Woman;Women Status;Work

PROJECT_TITLE: Pregnancy-associated mortality and morbidity due to drugs, self-harm, and violence in the United States

STUDY_SECTION: SSPB

STUDY_SECTION_NAME: Social Sciences and Population Studies B Study Section[SSPB]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Genetics;Human Genome;Lung

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: PROJECT NARRATIVE Channing Division of Network Medicine Training Program in Systems Approaches to the Epidemiology, Genetics, and Genomics of Lung Diseases Providing appropriate training in the application of the latest quantitative data analysis methods to understand the pathobiological causes of major lung diseases will be essential for the next generation of leaders in respiratory population-based research. This T32 program will build on a successful track-record of training with both formal didactic education and mentored research experiences. The medical researchers trained in this program have made, and will continue to make, important contributions to our understanding of asthma and COPD that will ultimately lead to more effective treatment for these diseases.

PI_NAMEs: SILVERMAN, EDWIN K;WEISS, SCOTT T (contact)

PROGRAM_OFFICER_NAME: ESPINOZA-PINTUCCI, MARISOL

PROJECT_TITLE: SYSTEMS APPROACHES TO THE EPIDEMIOLOGY, GENETICS AND GENOMICS OF LUNG DISEASES


ORG_CITY: CLEVELAND

ORG_NAME: LOUIS STOKES CLEVELAND VA MEDICAL CENTER

PHR: Project Narrative Diabetic retinopathy is the leading causes of blindness in the working-age population worldwide, and more than half of the Veterans being treated for diabetes in the VA system suffer from this visual disease. In our previous studies, we discovered that an inflammatory cytokine, IL-17A, plays a pivotal role in the onset and progression of diabetic retinopathy in diabetic mice. In the current study, we are determining if IL-17A plays the same pathologic role in the onset and progression of diabetic retinopathy in our VA patients. This could lead to the discovery of novel therapeutics for onset and progression of diabetic retinopathy.

PI_NAMEs: TAYLOR, PATRICIA R (contact)

PROJECT_TERMS: Address;Age;alternative treatment;Background Diabetic Retinopathy;Biological Assay;Blindness;Blood;Blood capillaries;Blood Vessels;Cancer Patient;Caring;Cells;Centrifugation;Chronic;Clinical Research;Collaborations;Complications of Diabetes Mellitus;cytokine;density;Diabetes Mellitus;diabetic;Diabetic mouse;Diabetic Retinopathy;Disease;Drug resistance;Early treatment;Enzyme-Linked Immunosorbent Assay;Extravasation;Eye;FDA approved;Ficoll;Fundus;Goals;Health;healthcare burden;IL17 gene;Immune system;Impairment;improved;Individual;Inflammation;Inflammatory;Injury;Interleukins;intravitreal injection;macula;macular edema;Malignant Neoplasms;Mediating;Microvascular Dysfunction;military veteran;mouse model;neutrophil;new therapeutic target;non-diabetic;novel;novel therapeutics;Operative Surgical Procedures;ophthalmic examination;Oxidative Stress;Pathogenesis;Pathologic;Patients;peripheral blood;Pharmaceutical Preparations;Plasma;Play;Population;Prediabetes syndrome;Production;Proliferating;proliferative diabetic retinopathy;Proteins;ranibizumab;Resistance;responders and non-responders;response;Retina;retina blood vessel structure;retinal angiogenesis;Retinal Diseases;Role;screening;Severities;Source;System;therapeutic target;Thick;Tight Junctions;Treatment Factor;Type 2 diabetic;Vascular Endothelial Growth Factors;Vascular Permeabilities;Vascular Proliferation;Veterans;Vision;Visual;Vitrectomy

PROJECT_TITLE: The role of IL-17A in the onset and progression of diabetic retinopathy in VA patients


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Bipolar Disorder;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Complementary and Integrative Health;Health Services;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Patient Safety;Primary Health Care;Schizophrenia;Serious Mental Illness;Social Determinants of Health;Telehealth

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE  In West Africa, the hardships of serious mental illnesses (SMI) such as schizophrenia and bipolar disorder are compounded by pervasive societal stigma, scarce treatment options, systematic exclusion, neglect, and abuse. Most people with SMI in West Africa receive care from traditional and faith healers who have no formal training in assessment, treatment of SMI, or preservation of human rights and patient safety. Our multinational team proposes to deploy and evaluate M&M: a dual-pronged intervention package comprised of a smartphone system designed to train healers and support their delivery of brief evidence-based psychosocial interventions (M-Healer) combined with pharmacotherapy delivered directly to the patients they are treating via visiting nurse (Mobile Nurse).

PI_NAMEs: BEN-ZEEV, DROR  (contact);OFORI-ATTA, ANGELA

PROGRAM_OFFICER_NAME: VEDHAM, VIDYA

PROJECT_TERMS: Address;Africa;African;Aftercare;Age;Amination;animation;Behavioral Model;Biological;Bipolar Disorder;Caring;Cellular Phone;Cessation of life;Clinical;clinical practice;Cluster randomized trial;Code;Cognitive;Collaborations;Communities;community engaged research;Computer software;Country;Coupled;Data;design;Development;Diagnosis;digital;digital health;digital mental health;disability;Education;effectiveness evaluation;Elements;Empathy;Enrollment;evidence base;Exclusion;experience;Exposure to;Faith Healing;Fasting;Feedback;field study;Focus Groups;Funding;future implementation;Ghana;global health;Grant;Health Alliance;Health Personnel;Healthcare Systems;Human Rights;Impairment;improved;improved outcome;Infrastructure;innovation;Institution;Intervention;intervention effect;Interview;Investigational Therapies;Language;Learning;low and middle-income countries;Measures;Mediating;Mediator;Mental Health;Mental Health Services;Methodology;mHealth;Mission;Modeling;Myeloma Proteins;Narration;National Institute of Mental Health;neglect;Nurses;Outcome;patient safety;Patient-Focused Outcomes;Patients;Persons;Pharmacotherapy;Pilot Projects;Prayers;preservation;Prevalence;programs;prototype;Psychiatric Hospitals;psychiatric symptom;psychologic;psychological distress;psychosocial;Qualitative Methods;Quality of Care;Quality of life;Relationship-Building;Research;research clinical testing;Resort;Resources;Rewards;Safety;Sampling;Schizophrenia;Services;severe mental illness;Severities;sex;Shame;Site;skills;social;social stigma;Specific qualifier value;Strategic Planning;System;Techniques;Technology;Terminology;Testing;theories;tool;traditional care;Training;treatment as usual;Treatment outcome;trial design;United States;usability;Visiting Nurse

PROJECT_TITLE: Combining mHealth and nurse-delivered care to improve the outcomes of people with seriousmental illness in West Africa


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: CHICAGO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Transitions of Care (TOC) between hospital, ambulatory, and home settings for high-risk, frequently hospitalized adults with chronic diseases, such as chronic obstructive pulmonary disease (COPD) are complex, costly, and vulnerable to safety threats and poor health outcomes. One potential solution to address this gap in care is the Transitional Care Model (TCM), which utilizes a patient-centered approach with in-home interventions; since in- person in-home visits are costly, using innovative telehealth, such as virtual visits via teleconferencing may be just as effective with greater feasibility, scalability, and sustainability, particularly in the post-COVID-19 era as we’ve seen the rapid expansion of these technologies. With our transdisciplinary team of experts from cognitive science, care transitions/handoffs, human factors engineering, design, implementation science, and health services research, we propose to implement and evaluate “TELE-TOC: Telehealth Education: Leveraging Electronic Transitions Of Care for COPD patients,” which includes a virtual visit, pharmacy-based, in-home intervention for COPD patients to improve medication use and patient outcomes among a population at high risk for readmission and medication safety events.

PI_NAMEs: ABRAHAM, JOANNA ;ARORA, VINEET ;PRESS, VALERIE G (contact)

PROGRAM_OFFICER_NAME: CHANEY, KEVIN

PROJECT_TITLE: TELE-TOC: Telehealth Education Leveraging Electronic Transitions Of Care for COPD Patients - Resubmission - 1

STUDY_SECTION: HITR

STUDY_SECTION_NAME: Healthcare Information Technology Research[HITR]


ORG_CITY: CHARLESTON

ORG_NAME: RALPH H JOHNSON VA MEDICAL CENTER

ORG_STATE: SC

PHR: Cognitive behavioral therapy (CBT) is a brief, efficient, and effective treatment for individuals with depressive/anxiety disorders. However, CBT is largely underutilized within the Department of Veterans Affairs due to the cost and burden of trainings necessary to deliver all of the related disorder-specific treatments (DSTs). Transdiagnostic Behavior Therapy (TBT), in contrast, is specifically designed to address numerous distinct disorders within a single protocol in Veterans with depressive/anxiety disorders, including posttraumatic stress disorder. The proposed research seeks to evaluate the efficacy of TBT by assessing psychiatric symptomatology and related impairment outcomes in Veterans with depressive/anxiety disorders via a randomized controlled trial of TBT and existing DSTs. Assessments will be completed at pre-, mid-, and post-treatment, and at 6-month follow-up. Process variables also will be investigated.

PI_NAMEs: GROS, DANIEL F. (contact)

PROJECT_TERMS: acceptability and feasibility;Address;Aftercare;Agoraphobia;Anxiety;Anxiety Disorders;anxiety symptoms;Appointment;Area;associated symptom;Behavior Disorders;Behavior Therapy;Behavioral;Client satisfaction;Clinical;Cognitive;Cognitive Therapy;comorbidity;comparison group;Competence;Consent Forms;cost;cost effective;depressive symptoms;design;Diagnosis;Diagnostic;diagnostic strategy;Disease;Dissemination and Implementation;effective therapy;efficacious treatment;efficacy evaluation;Equipment and supply inventories;Financial Hardship;follow-up;Funding;Goals;Healthcare;Impairment;improved;inclusion criteria;Individual;Informed Consent;innovation;Intake;Intervention;Investigation;K-Series Research Career Programs;Major Depressive Disorder;Measures;Mental Depression;Mental disorders;Outcome;Panic Disorder;Participant;Patient Self-Report;Population;Post-Traumatic Stress Disorders;Procedures;Process;Protocols documentation;Provider;psychiatric comorbidity;Psychiatric Diagnosis;Psychotherapy;Questionnaires;Randomized;Randomized, Controlled Trials;Recovery;Relapse;Research;Sampling;satisfaction;Severities;symptomatology;Symptoms;Testing;Time;Training;trait;treatment comparison;treatment effect;Treatment Protocols;trial comparing;trial design;United States Department of Veterans Affairs;Unnecessary Procedures;Veterans;willingness

PROJECT_TITLE: A Comparison of the Efficacy of Transdiagnostic Behavior Therapy and Disorder-specific Therapy in Veterans with PTSD, Anxiety, and Depression


NIH_SPENDING_CATS: Behavioral and Social Science;Chronic Obstructive Pulmonary Disease;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Dietary Supplements;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Effects of Household Energy Combustion;Health Effects of Indoor Air Pollution;Lung;Nutrition;Prevention;Social Determinants of Health

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE COPD is a leading cause of death in the US with low-income individuals experiencing increased prevalence and morbidity; and the proposed research represents new lines of investigation that build on previous studies identifying that dietary intake of omega-3 polyunsaturated fatty acids was well below recommended levels for the majority of participants in a low-income COPD cohort, and that lower intake levels were associated with worse COPD outcomes and increased susceptibility to indoor air pollution exposures. The OMEGA COPD Trial focuses on a food delivery dietary intervention targeting increased omega-3 intake to determine whether dietary modifications can improve COPD outcomes and attenuate the adverse effects of particulate matter exposure on respiratory health. Results will comprehensively address the impact of an evidence-based nutrition intervention on COPD health and provide a framework for dietary intervention within other chronic diseases disproportionately impacting susceptible, low-income populations.

PI_NAMEs: HANSEL, NADIA N (contact)

PROGRAM_OFFICER_NAME: PUNTURIERI, ANTONELLO

PROJECT_TERMS: Accounting;Address;Adult;Adverse effects;adverse outcome;Affect;Arbitration;Attenuated;Biological Markers;Cause of Death;Chronic Disease;Chronic Obstructive Pulmonary Disease;cohort;Communities;Data;design;Development;Diet;Diet Modification;dietary;Dietary intake;Dietary Intervention;Dietary Practices;Disease Outcome;Education;Eicosanoids;Enabling Factors;Environmental Exposure;environmental health disparity;epidemiology study;evidence base;experience;Food;Food Access;food insecurity;food preparation;Foundations;Funding;future implementation;Health;Health Food;High Prevalence;Home;implementation strategy;improved;Individual;Indoor Air Pollution;Indoor Air Quality;indoor concentrations;indoor particulate matter;Inflammatory;Infrastructure;Intake;Intervention;Intervention Studies;Interview;Investigation;Link;Low income;Low Income Population;modifiable risk;Modification;Morbidity - disease rate;mortality;nutrition;Nutritional;Omega-3 Fatty Acids;Outcome;Participant;Particulate Matter;Pathway interactions;Patients;Personal Behavior;Persons;policy implication;pollutant;Population;Predisposition;Prevalence;Pulmonary Inflammation;Qualitative Methods;Quality of life;Recommendation;Reduce health disparities;Research;respiratory;Respiratory Disease;respiratory health;respiratory morbidity;Respiratory Signs and Symptoms;Risk;Risk Factors;satisfaction;Serum;service delivery;Source;Structure;systemic inflammatory response;Testing;therapy design;Training;Underserved Population;Unhealthy Diet;United States;United States National Institutes of Health;voucher;Vulnerable Populations

PROJECT_TITLE: OMEGA COPD Trial

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-N(02)]


PHR: Narrative While researchers are actively studying the HIV-1 reservoir, much less is known about HIV-2 latency. Our study investigates the mechanisms that control HIV-2 latency and its reversal. We believe our approaches test previously unexplored hypotheses that are central to understand how HIV-2 latency and its reversal differs from HIV-1 - and whether this facilitates or hampers efforts to develop HIV-2 eradication approaches.

PI_NAMEs: TSIBRIS, ATHE M. (contact)

PROGRAM_OFFICER_NAME: NOVAK, LEIA KAYE

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Affect;antagonist;antiretroviral therapy;Benign;Biology;CD4 Positive T Lymphocytes;Cell Separation;cell type;Cells;Clonal Expansion;cohort;Complex;Data;design;DNA;experimental study;gene conservation;Gene Silencing;Genes;Genetic Transcription;Genome;Genomics;Goals;Heterochromatin;HIV;HIV-1;HIV-2;Human;human DNA;in vivo;Infection;integration site;Knowledge;Length;Lentivirus;Macrophage;Measures;Modeling;monocyte;multimodality;Participant;Patient Recruitments;Patients;Peripheral Blood Mononuclear Cell;permissiveness;Phylogenetic Analysis;Plasma;Plasmids;Play;posttranscriptional;Primate Lentiviruses;Production;Proteins;Proviruses;recruit;Reporter;Reporting;Repression;Research Personnel;Rest;RNA;Role;Series;single cell analysis;single cell ATAC-seq;single-cell RNA sequencing;Techniques;Testing;Time;transcriptome sequencing;Viral Load result;Virion;Virus;Virus Latency

PROJECT_TITLE: HIV-2 latency and its reversal

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIB-A(03)]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Precision Medicine;Radiation Oncology

ORG_CITY: MADISON

ORG_NAME: VOXIMETRY, INC.

ORG_STATE: WI

PHR: PROJECT NARRATIVE Millions of patients are treated with radiopharmaceutical therapy (RPT) each year. Unfortunately, current prescription methods do not consider absorbed dose to individual patients but instead use empirically derived or standard methods leading to suboptimal treatment outcomes in some patients. Our solution, Torch, will be the first commercialized full-Monte Carlo and automated patient-specific dosimetry software for RPT.

PI_NAMEs: GRUDZINSKI, JOSEPH ;WICKRE, PAUL  (contact)

PROGRAM_OFFICER_NAME: FRANCA-KOH, JONATHAN C

PROJECT_TERMS: 3-Dimensional;absorption;Acceleration;Address;Adoption;Algorithms;Antibodies;Artificial Intelligence;automated segmentation;Automation;Benchmarking;Biodistribution;Calibration;Cancer Patient;cancer therapy;Characteristics;chemotherapy;Clinic;Clinical;clinical decision support;clinical practice;clinically significant;commercialization;Computer software;Consensus;Contracts;cost effective;Deposition;design;Development;digital;Disseminated Malignant Neoplasm;Dose;dosimetry;Drug Kinetics;Ensure;Evaluation;experience;External Beam Radiation Therapy;Funding;Gamma Rays;Goals;Grant;Healthcare Systems;Image;image registration;individual patient;individualized medicine;Intellectual Property;Lead;Lymphoma;Marketing;Metastatic Prostate Cancer;Methods;Modeling;Neoplasm Metastasis;neoplastic cell;Neuroendocrine Tumors;Normal tissue morphology;Organ;Overdose;Patient-Focused Outcomes;Patients;Peptides;personalized medicine;Pharmaceutical Preparations;pharmacokinetic model;Phase;Physicians;Physiology;Radiation;Radioactivity;Radioisotopes;Radiopharmaceuticals;reconstruction;Reporting;Resources;response;Risk;Route;Secure;side effect;single photon emission computed tomography;Small Business Innovation Research Grant;small molecule;System;Technology;Testing;theranostics;Therapeutic;Time;tool;Treatment outcome;treatment planning;tumor;Tumor Tissue;uptake;user-friendly;Validation;verification and validation;Work

PROJECT_TITLE: One-click Automated 3D Treatment Planning for Radiopharmaceutical Therapy


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PHR: Project Narrative Chronic microglial activation is a key driver in traumatic brain injury (TBI)-induced persistent neuroinflammation. This proposal will characterize the role of microglial and non-microglia macrophage-like NOX2 in driving neurotoxic microglial responses following TBI.

PI_NAMEs: HENRY, REBECCA ;STOICA, BOGDAN ADRIAN (contact)

PROGRAM_OFFICER_NAME: AWWAD, HIBAH OMAR

PROJECT_TERMS: Address;Adult;Affective;Attenuated;attenuation;Automobile Driving;Blood Vessels;Bone Marrow;Brain;brain cell;Calibration;cell injury;Cells;Central Nervous System;Chimera organism;Chronic;Chronic Brain Injury;Chronic Phase;Cognitive;Cognitive deficits;CSF1R gene;Dementia;Development;Gene Expression;Gene Expression Profile;glial activation;Goals;Homeostasis;Impaired cognition;Impairment;Incidence;Infiltration;Inflammation;Inflammatory;inflammatory marker;inhibitor;Injury;Innate Immune System;Knock-out;Macrophage;Macrophage Activation;Mediating;Meningeal;Microglia;Molecular;monocyte;motor deficit;NADPH Oxidase;Nerve Degeneration;Neurodegenerative Disorders;neuroinflammation;Neurologic;Neurologic Deficit;Neurologic Dysfunctions;neurorestoration;neurotoxic;neurotoxicity;new therapeutic target;Oxidative Stress;Pathway interactions;Phagocytes;Phenotype;Play;Population;Process;programs;Property;Quality of life;repaired;response;Role;sex;single-cell RNA sequencing;Stimulus;TBI Patients;Testing;Therapeutic Intervention;therapeutically effective;Time;Tissues;Traumatic Brain Injury;Traumatic Brain Injury recovery

PROJECT_TITLE: NOX2 drives microglia-dependent neurodegeneration after traumatic brain injury


NIH_SPENDING_CATS: Cancer;Prevention

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Despite encouraging breakthroughs that have improved the five-year survival of cancer patients, the long-term prognosis for those with metastatic disease remains dismal. Patient mortality is due primarily to metastatic disease that is resistant to treatment and evades anti-tumor immunity. In this proposal, we seek to identify conserved mechanical reinforcement circuits that drive malignant transformation and progression focusing on inflammation and mitochondrial stress. Completion of the program should provide new insight into how inflammation and the extracellular matrix drive malignancy and foster the evolution of aggressive cancers, clarify how cancers circumvent critical bottlenecks they encounter during tumor progression and identify biomarkers to risk stratify patients and therapies to treat refractory tumors and for chemoprevention.

PI_NAMEs: WEAVER, VALERIE MARIE (contact)

PROGRAM_OFFICER_NAME: WOODHOUSE, ELIZABETH

PROJECT_TERMS: Actomyosin;Aggressive behavior;biomarker identification;Breast;Cancer Patient;cancer survival;candidate identification;cell growth;Chemoprevention;Chronic;Clinical;Cytoskeleton;Data;Disease;Drug Screening;Drug Targeting;Evolution;Exhibits;Extracellular Matrix;Fostering;Gene Expression;Genetic Induction;Glioblastoma;Homeostasis;improved;in vivo;Inflammation;innovation;insight;Invaded;Malignant - descriptor;Malignant Neoplasms;Measures;Mechanics;Metabolic;Mitochondria;Modification;Molecular;Monitor;mortality;mouse model;Myeloid Cells;Neoplasm Metastasis;neoplastic cell;Pancreas;patient stratification;Patients;Phenotype;predictive marker;Prognosis;programs;Psychological reinforcement;Refractory;Repression;Research;Resistance;Risk;risk stratification;Role;Signal Transduction;Stress;Testing;three dimensional cell culture;Tissues;tumor;Tumor Immunity;tumor progression;Work

PROJECT_TITLE: Tissue mechanics reprograms the tissue to malignancy and metastasis


ORG_CITY: BUFFALO

ORG_NAME: VA WESTERN NEW YORK HEALTHCARE SYSTEM

PHR: Chronic pain is very common among primary care Veterans and can seriously impact overall patient functioning and well-being. Currently, behavioral methods of pain management are not often provided in primary care because they are designed to be delivered in specialty care settings. To address this gap in care, the proposed study will test if Brief Cognitive Behavioral Therapy for Chronic Pain (Brief CBT-CP) is an effective treatment. Brief CBT-CP has been designed specifically for VA mental health providers working in primary care. The goal of this treatment is to help Veterans manage their chronic pain and distress by teaching behavioral and cognitive skills. Brief CBT-CP delivers these skills in less time than many other behavioral treatments. If Brief CBT-CP is found to be effective, it may be used to provide early treatment by offering it in routine primary care.

PI_NAMEs: BEEHLER, GREGORY P (contact)

PROJECT_TERMS: Address;Affect;Aftercare;Analgesics;Appointment;arm;Behavior Therapy;Behavioral;behavioral health;biopsychosocial;Caring;Centers for Disease Control and Prevention (U.S.);chronic musculoskeletal pain;chronic pain;chronic pain management;chronic pain patient;Clinic;Clinical;clinically significant;cognitive skill;Cognitive Therapy;Complement;Complex;Data;Demographic Factors;depressive symptoms;design;Distress;Early treatment;Educational process of instructing;effective therapy;effectiveness trial;expectation;Feeling suicidal;follow-up;Functional impairment;functional improvement;functional status;Funding;Goals;Guidelines;Health Personnel;Healthcare Systems;improved;Intervention;Interview;Length;Life;Mediator;medical specialties;Mental Health;Mental Health Services;Methods;Mission;multidisciplinary;multilevel analysis;New York;Nonpharmacologic Therapy;Opioid;opioid therapy;Outcome;Pain;Pain Clinics;Pain intensity;Pain management;Pain Management Method;Pain Measurement;Participant;Patient Self-Report;Patient-Focused Outcomes;Patients;Personal Satisfaction;Positioning Attribute;Primary Care;primary care provider;primary care services;primary outcome;programs;Provider;psychologic;Psychotherapy;Quality of life;Randomized;Randomized, Controlled Trials;Recommendation;Recovery of Function;recruit;Reporting;Role;satisfaction;secondary outcome;Self Efficacy;Services;Signal Transduction;Single-Blind Study;skills;Statistical Data Interpretation;Structure;Testing;Therapeutic;Time;treatment as usual;treatment comparison;Veterans

PROJECT_TITLE: Brief Cognitive Behavioral Therapy for Chronic Pain to Improve Functional Outcomes amongPrimary Care Veterans

STUDY_SECTION: RRDE

STUDY_SECTION_NAME: Behavioral Health & Social Reintegration[RRDE]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: FARMINGTON

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT

ORG_STATE: CT

PHR: PROJECT NARRATIVE The ENCORE (Encyclopedia of RNA Elements) project produces physical resources and datasets that form the reference annotation for RNA binding protein-RNA interactions in the human genome, providing a standard for insights into co- and post- transcriptional regulation in the short run, and consequences of expressed genetic variation in the long term, contributing to fundamental knowledge to benefit public health.

PI_NAMEs: GRAVELEY, BRENTON R. (contact);YEO, EUGENE WEI-MING

PROGRAM_OFFICER_NAME: MORRIS, STEPHANIE A

PROJECT_TERMS: Binding;Binding Proteins;Biology;Cells;Clinical;Collection;Communities;Complement;Data;Data Element;data portal;data repository;Data Set;Disease;Education;Education and Outreach;Elements;Encyclopedias;Etiology;Gene Expression;gene regulatory network;Genes;Genetic Diseases;Genetic Variation;Genomic approach;Goals;Human;Human Biology;Human Cell Line;human disease;Human Genome;insight;knock-down;Knock-out;Knowledge;Link;Maps;Measurement;Methods;Molecular;Molecular Profiling;online resource;outreach;Post-Transcriptional Regulation;posttranscriptional;Process;Production;Proteins;Public Health;Reagent;Reference Standards;Regulation;Reporting;Research;Resources;RNA;RNA-Binding Proteins;RNA-Protein Interaction;Role;transcriptome;transcriptome sequencing;Untranslated RNA;web interface

PROJECT_TITLE: A comprehensive binding and functional map of human RNA-binding proteins


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Fetal Alcohol Spectrum Disorders (FASD);Intellectual and Developmental Disabilities (IDD);Mental Health;Microbiome;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Substance Misuse

ORG_CITY: St Catharines

ORG_COUNTRY: CANADA

ORG_FIPS: CA

ORG_NAME: BROCK UNIVERSITY

ORG_STATE: ON

ORG_ZIPCODE: L2S 3A1

PHR: 8. Project Narrative  Prenatal alcohol exposure (PAE) is an early-life insult that programs developing systems and can predispose the organism to a myriad of health-related conditions, including mental health problems (e.g., depression/anxiety) and immune system dysfunction over the life course. The present proposal will investigate whether altered gut structure and function and shifts in microbiota (bacteria) composition, which are known to increase inflammation in both the brain and the body, may underlie the increased susceptibility to mental health problems seen following PAE. Elucidation of the mechanisms underlying risk for and resilience to mental health problems is critical for improving early intervention strategies and long-term health and well-being for individuals with Fetal Alcohol Spectrum Disorders (FASD).

PI_NAMEs: BODNAR, TAMARA SONIA;RAINEKI, CHARLIS  (contact)

PROGRAM_OFFICER_NAME: AKBAR, MOHAMMED

PROJECT_TERMS: Adult;Affect;Alcohol consumption;alcohol consumption during pregnancy;Alcohols;Animal Model;Anxiety;Bacteria;Birth;Blood Circulation;Brain;Child;Chronic;Clinical;Clinical Research;Clinical Treatment;cohort;Complex;Development;Disease;disorder risk;Early Intervention;Effectiveness;efficacy evaluation;emotion dysregulation;Environment;experience;experimental study;fecal transplantation;Fetal alcohol effects;Fetal Alcohol Exposure;Fetal Alcohol Spectrum Disorder;Future;Goals;Grant;gut microbiota;gut-brain axis;Health;Health Status;Human;Immune;immune activation;immune function;Immune response;Immune system;Immune System Diseases;Impairment;improved;Incidence;Individual;infancy;Infant;Inflammation;Inflammatory;insight;Intervention;Intestinal permeability;intrauterine environment;late life;Leaky Gut;Life;Life Cycle Stages;life span;Link;Literature;Mental Depression;Mental disorders;Mental Health;microbiota;microbiota composition;Neuroimmune;Neurosecretory Systems;novel;novel marker;Organism;Outcome;Pathogenesis;Pattern;Peripheral;Permeability;Personal Satisfaction;Pharmacological Treatment;Predisposition;Pregnancy;prenatal;programs;Publications;Recovery;Research;resilience;response;Risk;Severities;Signal Transduction;Structure;System;Time;Translating;treatment strategy;Woman;Work

PROJECT_TITLE: Prenatal Alcohol and Neuroimmunity

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


NIH_SPENDING_CATS: Brain Disorders;Cerebrovascular;Clinical Research;Genetics;Neurodegenerative;Neurosciences;Pediatric;Prevention;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE Cerebral Adrenoleukodystrophy is an inherited devastating disease where inflammatory cells infiltrate the brain and cause progressive degeneration that leads to vegetative state or death in months to years. Unfortunately, current therapies either fail to prevent cerebral disease or carry high toxicity and mortality. In this project we will study how the gene defect changes the brain vessel permeability to allow access of inflammatory cells to the brain using laboratory tools at the bench. If validated by this study, our approach sets forth a successful strategy for identifying factors that contribute to develop cerebral degeneration and a laboratory tool urgently needed to screen for new less toxic and targeted therapies.

PI_NAMEs: MUSOLINO, PATRICIA L (contact)

PROGRAM_OFFICER_NAME: MORRIS, JILL A

PROJECT_TERMS: Acute;Address;Adhesions;Adrenoleukodystrophy;Affect;Age of Onset;Animal Model;Astrocytes;Binding;Biological;Biological Assay;Biological Models;Blood - brain barrier anatomy;Blood brain barrier dysfunction;blood-brain barrier disruption;blood-brain barrier function;blood-brain barrier permeabilization;Brain;brain dysfunction;brain endothelial cell;Cell Adhesion Molecules;Cell model;Cells;cerebral degeneration;Cerebral endothelium;Cerebrum;Cessation of life;Coculture Techniques;Code;cytokine;Data;Defect;Demyelinations;Development;differential expression;Disease;disease model;Dose;Down-Regulation;early childhood;Electrical Resistance;Endothelium;Event;experimental study;Extravasation;Female;Functional disorder;Future;Gene Dosage;Gene Mutation;Gene Silencing;Gene Targeting;gene-editing approach;Genes;Genetic Transcription;Genotype;Heterozygote;Human;human induced pluripotent stem cells;imaging study;Individual;induced pluripotent stem cell;Infiltration;Inflammatory;Inherited;insight;Knowledge;Laboratories;Leukocytes;Maintenance;male;Mediating;migration;Modeling;Molecular;mortality;Mutation;Nervous System Disorder;neuroinflammation;novel;novel therapeutic intervention;Oncogenes;Pathway interactions;Patients;Penetrance;Pericytes;Permeability;peroxisome;Phenotype;prevent;Preventive;Preventive treatment;promoter;Proteins;Regulation;Regulatory Pathway;Role;Signal Pathway;small molecule;Stress;targeted treatment;Techniques;Testing;TGFB1 gene;Tight Junctions;tool;Toxic effect;transcription factor;Transcriptional Regulation;transcriptome sequencing;Transforming Growth Factor beta;validation studies;Vascular Endothelium;Vegetative States;Very Long Chain Fatty Acid;Viral;Work

PROJECT_TITLE: Effects of ABCD1 Deficiency on Endothelial Function and Permeability to Leukocytes in Cerebral X-linked Adrenoleukodystrophy

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Immunotherapy;Precision Medicine;Women's Health Research

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: Project Narrative Breast cancers are associated with defects in antigen presenting cells, partially explaining poor immune responses against breast cancers and limited benefit from current immunotherapies. We recently identified that the novel combination of CD40 agonist, Flt3 ligand, and pegylated liposomal doxorubicin improves antigen presentation and significantly controls tumor growth of triple negative breast cancers in mice. This proposal will test this novel therapy in patients with metastatic triple negative breast cancer and through a combination of patient tissue profiling and mouse experiments will identify how the therapy works, which patients are likely to respond, and mechanisms of treatment resistance.

PI_NAMEs: REDDY, SANGEETHA MEDA (contact)

PROGRAM_OFFICER_NAME: RADAEV, SERGEY

PROJECT_TERMS: 4T1;adaptive immunity;Address;Advisory Committees;Agonist;Anthracycline;Antigen Presentation;Antigen Targeting;Antigen-Presenting Cells;Antigens;B-Lymphocytes;Bioinformatics;Biological Markers;biomarker identification;Breast;Breast Cancer Patient;cancer subtypes;cancer therapy;CD8-Positive T-Lymphocytes;cell type;Cells;chemotherapy;Clinical;clinical efficacy;clinical investigation;Clinical Trials;Clinical Trials Design;Combination Drug Therapy;Correlative Study;Data;Defect;Dendritic Cells;Development;disorder control;efficacy study;Exhibits;experimental study;FLT3 ligand;Foundations;Frequencies;Funding;Future;Growth Factor;humanized mouse;Immune;immune checkpoint blockade;Immune response;Immune Tolerance;Immunologic Markers;Immunologic Monitoring;Immunologics;Immunologist;Immunooncology;Immunotherapy;improved;improved outcome;Individual;Investigation;Lead;Malignant Breast Neoplasm;Malignant neoplasm of pancreas;Malignant Neoplasms;Mediating;Medical center;Medical Oncologist;Mentorship;Mesenchymal;Modeling;mouse model;Mus;novel;novel therapeutics;organizational structure;Pathway interactions;patient derived xenograft model;Patients;Pharmacodynamics;Phase;Physicians;pilot trial;pre-clinical;Pre-Clinical Model;preclinical study;Principal Investigator;Process;professor;Randomized;randomized, clinical trials;Regimen;Research;Resistance;resistance mechanism;Resources;response;response biomarker;Safety;safety assessment;Scientist;Solid Neoplasm;Sterically Stabilized Liposome;success;supportive environment;synergism;T-Lymphocyte;tertiary lymphoid organ;Testing;Therapeutic;therapy resistant;Tissue Sample;Tissues;TNFRSF5 gene;TNFSF5 gene;Training;Training Programs;Translational Research;triple-negative invasive breast carcinoma;Triplet Multiple Birth;tumor;Tumor Antigens;tumor growth;Tumor Immunity;Tumor Markers;tumor-immune system interactions;uptake;Work

PROJECT_TITLE: Enhancing antigen presentation in triple negative breast cancers through CD40 agonist, Flt3 ligand, and anthracycline chemotherapy

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


ADMINISTERING_IC: DC

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Behavioral and Social Science;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Pediatric

ORG_CITY: Newark

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF DELAWARE

ORG_STATE: DE

PHR: Project Narrative Developmental Language Disorder affects approximately seven percent of the population and is characterized by grammatical deficits that cascade into lifelong academic challenges and under-employment. Current treatments for DLD produce good outcomes under ideal, high intensity conditions or when parents have been trained to deliver therapy using intense coaching methods; however, current publicly funded service delivery systems and private-pay reimbursement models do not support treatment being delivered in this ideal fashion for children older than three. This project will examine alternative methods of delivering treatment that may be more feasible under typical conditions and will identify implementation barriers, with the goal of improving long- term outcomes for children with DLD.

PI_NAMEs: VAN HORNE, AMANDA JEAN OWEN (contact)

PROGRAM_OFFICER_NAME: STORKEL, HOLLY LYNN

PROJECT_TERMS: Adherence;Adopted;Adoption;Adult;Advocate;Affect;Age;alternative treatment;Behavior;Books;caregiver education;Caregivers;Characteristics;Child;Childhood;comparative efficacy;Complex;Comprehension;comprehension deficit;cost;Data;design;Development;Disease;Dose;Educational Curriculum;Effectiveness;Enrollment;Equation;Exposure to;Feedback;Funding;Future;Goals;Home;implementation barriers;improved;Individual;interactive feedback;Intervention;Knowledge;Laboratories;Language Development;Language Development Disorders;Laws;Learning;Learning Difficulty;literacy;Methods;Modeling;Nature;Outcome;parenting intervention;Parents;Pattern;Population;Privatization;Production;Provider;Quality of life;Randomized, Controlled Trials;Reader;Reading;Recommendation;remediation;Reporting;Risk;Role;scale up;School-Age Population;service delivery;Service delivery model;Service provision;skills;Speech;Speech Pathologist;standard of care;Structure;success;syntax;System;Techniques;Theoretical Domains framework;Training;Underemployment;visual tracking;Width;Work

PROJECT_TITLE: Recasting and book reading under ideal (dose-controlled) and typical (dose-variable) conditions: The role of fidelity and adherence in production and comprehension outcomes for children with DLD

STUDY_SECTION: LCOM

STUDY_SECTION_NAME: Language and Communication Study Section[LCOM]


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Biotechnology;Hematology;Infectious Diseases;Lung;Rare Diseases;Sepsis

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: PROJECT NARRATIVE Sepsis-induced acute lung injury (sepsis-ALI) is a pulmonary dysfunction caused by dysregulated host response to infection. This project aims to establish novel approaches to ameliorate sepsis-ALI through selective inhibition of peptidylarginine deiminase 2 (PAD2) and/or sequestration of citrullinated H3 (CitH3).

PI_NAMEs: ALAM, HASAN B;LI, YONGQING  (contact)

PROGRAM_OFFICER_NAME: ESPINOZA GRANDON, INGRID CECILIA

PROJECT_TERMS: Acute Lung Injury;Animal Model;Antibodies;Antibody Response;Arginine deiminase;Bacteria;Binding;Biological;Biological Markers;Biological Process;Biology;Bone Marrow;Bronchoalveolar Lavage Fluid;CASP1 gene;Caspase;Cause of Death;cecal ligation puncture;Cell Death;Cells;Cellular biology;Cessation of life;Chemicals;Circulation;Clinical;Clinical Research;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;Data;Dose;Drug Kinetics;effective therapy;Endocytosis;Endotoxins;Enzymes;experimental study;Foundations;Functional disorder;Future;gene editing technology;Goals;Histone H3;Histones;Human;IL18 gene;Immune response;improved;Infection;Inflammation Mediators;Inflammatory;inflammatory marker;inhibitor;Injections;insight;Interleukin-1 beta;intravenous injection;Investigation;Knock-out;Knowledge;Label;Life;Link;Lung;lung injury;Macrophage;Manuscripts;Mediating;Membrane;Membrane Potentials;Molecular Biology;Monoclonal Antibodies;Morbidity - disease rate;mortality;mouse model;multidisciplinary;Mus;neutrophil;new therapeutic target;novel;novel strategies;Nuclear;Organ;organ injury;Pathogenesis;Pathologic;Pathway interactions;Patients;Peptides;Phagocytes;Pharmaceutical Preparations;Phenotype;Physiological;Predisposition;Protein-arginine deiminase;Proteomics;Pseudomonas aeruginosa;Pseudomonas aeruginosa pneumonia;Publishing;receptor;Reporting;Research;Resistance;response;Role;Safety;Science;Sepsis;septic;septic patients;Serum;Serum Markers;Signal Transduction;Signaling Molecule;success;Therapeutic;therapeutic target;Time;Tissues;Translating;uptake;Wild Type Mouse

PROJECT_TITLE: PAD2 and CitH3 in Pathogenesis of Sepsis-induced ALI

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics

ORG_CITY: MINNEAPOLIS

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative Human Pumilio proteins, PUM1 and PUM2, are essential proteins that control the flow of genetic information from genes to proteins. Defects in their function lead to neurological diseases including seizures, intellectual disability, and neurodegeneration. This proposal seeks to comprehensively understand their regulatory function and identify the genes they control.

PI_NAMEs: GOLDSTROHM, AARON CHARLES (contact)

PROGRAM_OFFICER_NAME: VATAKIS, DIMITRIOS NIKOLAOS

PROJECT_TERMS: Aging;Binding;Biochemical;Biological Assay;Biological Process;Biology;Cells;Chemicals;Complex;Cytoplasm;Data;Data Analyses;Defect;Development;Disease;Embryonic Development;Enzymes;experimental study;Fractionation;Functional disorder;Gametogenesis;Gene Expression;Gene Expression Regulation;gene repression;Genes;Genetic;genetic information;Goals;Hematopoiesis;Human;human disease;improved;In Vitro;in vivo;Infertility;insight;Intellectual functioning disability;Knowledge;Lead;Link;Malignant Neoplasms;Maps;Measures;Mediating;Mediator;Messenger RNA;mitochondrial dysfunction;mRNA Decay;mRNA Transcript Degradation;mRNA Translation;Nerve Degeneration;Nervous System Disorder;neurogenesis;Outcome;Pathogenesis;Poly(A)-Binding Protein I;Poly(A)-Binding Proteins;polyadenosine;Polyribosomes;Positioning Attribute;posttranscriptional;Prevalence;Process;Production;Proteins;Proteome;recruit;Regulation;Reporter;Repression;Research;Resolution;Response Elements;ribosome profiling;Ribosomes;RNA;RNA Decay;RNA Degradation;RNA Sequences;RNA-Binding Proteins;Role;Seizures;Specific qualifier value;stem cell fate;Structure;synergism;Tail;Time;tool;transcription regulatory network;translation factor;Translation Process;Translational Regulation;Translational Repression;Translations

PROJECT_TITLE: Translational Control by Human Pumilio Proteins

STUDY_SECTION: MG

STUDY_SECTION_NAME: Molecular Genetics Study Section[MG]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Clinical Research;Digestive Diseases;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Inflammatory Bowel Disease;Microbiome;Racial and Ethnic Minority Health Research

ORG_CITY: LOS ANGELES

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

PHR: The inflammatory bowel diseases (IBD) are chronic debilitating immune mediated diseases of the gut that are a significant cause of morbidity and healthcare utilization. The incidence and prevalence of IBD are increasing including in populations underrepresented in genetic studies such as African Americans and Hispanics who are also reported to have more severe disease. The majority of patients with IBD do not go into remission even with our most effective therapies (ant-TNF medications) and there is an urgent need to understand the underlying causes of the development of IBD and also the mechanisms of resistance to current treatment strategies in order to improve the quality of life of the millions of people with IBD.

PI_NAMEs: MCGOVERN, DERMOT PATRICK (contact)

PROGRAM_OFFICER_NAME: SHEA-DONOHUE, TEREZ

PROJECT_TERMS: Address;Admixture;admixture mapping;African American population;American;Anti-Tumor Necrosis Factor Therapy;Ants;Area;Bacteria;biobank;Biological Assay;Biological Markers;Biological Models;Biological Response Modifier Therapy;Biopsy;cell bank;Cell Culture System;Cell Line;Cells;cellular targeting;Chronic;chronic inflammatory disease;Clinical;clinical remission;Code;cohort;Collaborations;Collection;Complex;Coupled;Crohn's disease;Data;Development;Digestive System Disorders;Disease;Disease Progression;Disease remission;effective therapy;Elements;Environment;Environmental Risk Factor;Epithelium;European;European ancestry;exome sequencing;follower of religion Jewish;Gene Expression;Gene Expression Profile;Genes;Genetic;genetic analysis;genetic approach;genetic architecture;Genetic Predisposition to Disease;Genetic study;Genetic Transcription;genetic variant;Genetic Variation;Health Care Costs;health care service utilization;Heritability;Hispanic;Hispanic Americans;Hispanic ancestry;Hispanic Populations;host microbiome;Human;Immune;Immune response;improved;Incidence;Individual;induced pluripotent stem cell;Inflammatory;Inflammatory Bowel Diseases;Infrastructure;innovation;innovative technologies;insight;intestinal epithelium;Intestines;Investigation;Knowledge;Maps;Mediating;Medical;microbial;microbiome;Minority Groups;Molecular;Molecular Profiling;Morbidity - disease rate;multimodality;Native American Ancestry;Native Americans;new technology;novel;novel marker;novel therapeutics;Operative Surgical Procedures;Organoids;Outcome;Pathway interactions;Patients;Peripheral;Persons;Pharmaceutical Preparations;Population;Population Heterogeneity;Predisposition;Prevalence;Prospective cohort;protein expression;proteogenomics;Quality of life;recruit;Recurrence;Reporting;Research;Research Design;resistance mechanism;Resources;response;Science;Serology;Serum Markers;Signal Transduction;social disparities;Surrogate Markers;Susceptibility Gene;targeted treatment;Technology;Testing;Time;TNF gene;translational approach;treatment strategy;Ulcerative Colitis;Underrepresented Minority;Underrepresented Populations;Variant;Work

PROJECT_TITLE: Understanding genetic architecture and host-microbiome interactions in Inflammatory bowel disease in under-represented minority populations and in patients with unmet medical need.


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Down Syndrome;Intellectual and Developmental Disabilities (IDD);Lung;Neurosciences;Pediatric;Sleep Research

ORG_CITY: TUCSON

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: Project Narrative Obstructive sleep apnea is common in children with Down syndrome and current treatments such as adenotonsillectomy and positive airway pressure therapy have limited effectiveness in children with Down syndrome. This project will evaluate the combination of two medications, atomoxetine and oxybutynin, as a treatment for obstructive sleep apnea in children with Down syndrome. Effective obstructive sleep apnea therapy with these medications may lead to improved quality of life and cognition in children with Down syndrome.

PI_NAMEs: COMBS, DANIEL  (contact)

PROGRAM_OFFICER_NAME: BROWN, MARISHKA

PROJECT_TERMS: Adherence;Adolescent;Adult;Apnea;atomoxetine;Child;Childhood;Cognition;Data;Down's Syndrome;Effectiveness;efficacious treatment;efficacy evaluation;Growth;health related quality of life;high risk;Hypoglossal nerve structure;Impaired health;improved;indexing;Infant;mosaic;Muscle hypotonia;Neurocognition;Neurocognitive;Neurocognitive Deficit;novel;Obstructive Sleep Apnea;Outcome;oxybutynin;Performance;Pharmaceutical Preparations;Phase;positive airway pressure;Prevalence;Quality of life;Research;Residual state;Route;Schools;Second Look Surgery;Sleep;targeted treatment;Time;Treatment Effectiveness

PROJECT_TITLE: Medications for Obstructive Sleep Apnea to Improve Cognition in Children with Down Syndrome (MOSAIC DS)


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Attention Deficit Hyperactivity Disorder (ADHD);Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Fragile X Syndrome;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Mental Illness;Neurosciences;Pediatric;Rare Diseases;Women's Health Research

ORG_CITY: FLUSHING

ORG_DEPT: PSYCHOLOGY

ORG_NAME: QUEENS COLLEGE

ORG_STATE: NY

PHR: PROJECT NARRATIVE Because few studies have been conducted on an unbiased population of children who carry a fragile X premutation, there is little understanding of their risk for neurodevelopmental problems; the existing studies have raised concerns and questions among families and their health care providers while providing few answers due to the limited information. We propose to characterize neurodevelopment in children with a premutation using a unique large cohort ascertained without reference to phenotype. Our study will clarify risks and pave the way to develop new diagnostic criteria and appropriate interventions and therapies as needed.

PI_NAMEs: ADAYEV, TATYANA ;ALLEN, EMILY GRAVES;HINTON, VERONICA J (contact);HUNTER, JESSICA EZZELL

PROGRAM_OFFICER_NAME: KAU, ALICE S

PROJECT_TERMS: 12 year old;Address;Adult;adverse outcome;Age;Alleles;Anxiety;Anxiety Disorders;anxiety symptoms;associated symptom;Attention deficit hyperactivity disorder;Attentional deficit;autism spectrum disorder;Basic Science;Behavioral;boys;CGG repeat;CGG repeat expansion;Characteristics;Child;Child Behavior;Child Rearing;Childhood;Clinical;clinically significant;Cognitive;cohort;Development;Developmental Delay Disorders;Developmental Disabilities;Diagnosis;diagnostic criteria;Disease;Eligibility Determination;Emotional;ethnic diversity;Evaluation;Executive Dysfunction;executive function;Family;Family history of;FMR1 gene;Fragile X Premutation;Fragile X Syndrome;Frequencies;Functional disorder;FXTAS;genetic information;Genetic Screening;girls;Goals;Health;Health Personnel;Healthcare;Individual;Inherited;insight;Intellectual functioning disability;Interruption;Intervention;Interview;Knowledge;Late-Onset Disorder;Length;Life;Link;Literature;Mathematics;Measures;meetings;Memory impairment;Mental Depression;Mental Health;Mid-Atlantic Region;Molecular;Mothers;multidisciplinary;Mutation;mutation carrier;neurodevelopment;Neurodevelopmental Deficit;Neurodevelopmental Problem;neuropsychiatric disorder;Neuropsychology;New York;novel diagnostics;Outcome;Parents;Participant;Performance;Persons;pharmacologic;Phenotype;Population;prenatal;Prenatal Diagnosis;Prevalence;prevent;primary ovarian insufficiency;proband;prospective;psychologic;Questionnaires;racial diversity;Reading;Recording of previous events;remote administration;Reporting;Risk;Risk Factors;Sample Size;School-Age Population;Services;Severities;sex;Short-Term Memory;Siblings;skills;social;social deficits;social skills;Standardization;Stress;Structure;Surveys;Testing;Toxic effect;Visuospatial;Well in self;Woman;X Chromosome

PROJECT_TITLE: Association of the Fragile X Premutation with Cognitive and Behavioral Skills in Children

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


ORG_CITY: BOSTON

ORG_NAME: VA BOSTON HEALTH CARE SYSTEM

PHR: The development of a useful pre-treatment predictor of selective serotonin reuptake inhibitor (SSRI) response is an important public health challenge of particular relevance to VA. There is an exceptionally large number of Veterans with PTSD who are prescribed this class of medications and a high percentage of these Veterans are treatment non-responders. The goal of this proposal is to develop an easily implemented and noninvasive biological screening method that can be used to identify those Veterans who are likely to be clinically responsive to an SSRI and those Veterans who might be better candidates for another medication [e.g., serotonin-norepinephrine reuptake inhibition (SNRI)]. These findings will guide a precision medicine approach when choosing psychopharmacological interventions.

PI_NAMEs: PINELES, SUZANNE  (contact)

PROJECT_TERMS: Adherence;adverse outcome;Adverse reactions;Auditory;Auditory Evoked Potentials;auditory stimulus;Biological;Blood Platelets;Blood specimen;Brain;Chronic Post Traumatic Stress Disorder;Clinic;Clinical;clinical application;cost;Data;Dependence;depressed patient;depressive symptoms;Development;Diagnosis;disability payment;Electrocardiogram;Electrophysiology (science);endophenotype;Event-Related Potentials;Family;Female;follow up assessment;Functional impairment;Future;Goals;Human Resources;Impulsivity;Individual;ineffective therapies;Intervention;Lead;Loudness;male;Measurement;Measures;medication compliance;men;Mental Depression;Methodology;Methods;neurotransmission;Norepinephrine;Outcome Measure;Participant;Patient Self-Report;Patients;Personality;Pharmaceutical Preparations;Phase;physical conditioning;Placebos;Population;Post-Traumatic Stress Disorders;precision medicine;Prediction of Response to Therapy;Premedication;Procedures;Productivity;Provider;psychiatric symptom;psychopharmacologic;Public Health;randomized, clinical trials;Recommendation;Recording of previous events;Research;Research Design;response;reuptake;Sampling;screening;Selective Serotonin Reuptake Inhibitor;Series;Serotonin;Sertraline;Severities;side effect;Single-Blind Study;Site;Statistical Data Interpretation;Suicide attempt;Symptoms;Technology;Testing;Time;Training;transmission process;treatment as usual;treatment response;Veterans;Veterans Health Administration;Woman;Work

PROJECT_TITLE: An electrophysiological predictor of SSRI response in Veterans with PTSD

STUDY_SECTION: MHBB

STUDY_SECTION_NAME: Mental Health and Behavioral Science B[MHBB]