NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;HIV/AIDS;Immunization;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: NEW ORLEANS

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PI_NAMEs: KAUR, AMITINDER  (contact)

PROJECT_TERMS: Biological Assay;Catalogs;Cellular Immunology;Contracts;Data;Data Analyses;Deposition;Equipment and supply inventories;Evaluation;Freezing;HIV;Immune response;immunogenicity;Immunology procedure;improved;In Vitro;in vivo;Laboratories;Mycobacterium tuberculosis;pathogen;pre-clinical;Prevention strategy;Process;Reporting;Sampling;simian human immunodeficiency virus;SIV;Specimen;Testing;vaccine efficacy

PROJECT_TITLE: Cellular Immunology Core Laboratory


ADMINISTERING_IC: AI

ARRA_FUNDED: N

FUNDING_MECHANISM: NON SBIR/STTR CONTRACTS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: BOULDER

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: CRESTONE, INC.

ORG_STATE: CO

PI_NAMEs: OCHSNER, URS  (contact)

PROJECT_TERMS: Advanced Development;Bacterial Antibiotic Resistance;Bacterial Drug Resistance;bacterial resistance;biodefense;candidate selection;Chemistry;Clinical assessments;Combating Antibiotic Resistant Bacteria;efficacy evaluation;Emerging Communicable Diseases;lead optimization;manufacture;pathogen;pre-clinical;product development;research and development;Research Support;safety assessment;Staphylococcus aureus;Streptococcus;Therapeutic;therapeutic candidate;therapeutic development

PROJECT_TITLE: Development of Therapeutic Products for Antibiotic Resistant Bacteria


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Genetics;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: CLEVELAND

ORG_DEPT: PHARMACOLOGY

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE Ewing sarcoma is a cancerous bone tumor affecting children and young adults, which still lacks effective therapy and continues to be associated with high rates of mortality. Transcription factor ETV6 is a vulnerability in Ewing sarcoma cells while being largely dispensable in normal tissues, indicating a wide therapeutic index for perturbing ETV6 function in this disease. This proposal is dedicated to characterizing the cancer maintenance function of ETV6 and leveraging this new knowledge to develop beneficial therapies for Ewing sarcoma patients.

PI_NAMEs: GAO, YUAN  (contact)

PROGRAM_OFFICER_NAME: BOURCIER, KATARZYNA

PROJECT_TERMS: Acute;Advisory Committees;Affect;Allosteric Regulation;anti-cancer;base editing;Binding;Biochemical;Bone neoplasms;Bone Tissue;cancer cell;Cancer cell line;cancer type;Cancerous;Cell Death;Cell Differentiation process;Cell Line;Cell Physiology;Cells;Chemicals;Child;Chimeric Proteins;Chromosomal translocation;Clustered Regularly Interspaced Short Palindromic Repeats;CRISPR screen;Death Rate;Dedications;Dependence;Development;Differentiated Gene;Differentiation and Growth;Disease;DNA;DNA Binding;DNA Binding Domain;Dominant-Negative Mutation;drug development;Drug Targeting;effective therapy;Elements;Engineering;Environment;ETV6 gene;Ewings sarcoma;EWS-FLI1 fusion protein;Exons;Faculty;Family;Family member;fitness;FLI1 gene;functional genomics;Funding Mechanisms;Future;Gene Expression;Generations;Genetic study;Genome;Goals;Growth;In Vitro;in vivo;Knowledge;Maintenance;Malignant Bone Neoplasm;Malignant Neoplasms;Mediating;meetings;Mentors;Mesenchymal Differentiation;Metabolic Control;Methodology;Monitor;Mus;Mutagenesis;Mutation;Normal tissue morphology;novel;Oncogenic;Patients;Pediatric Oncology;Penetration;Peptides;Phase;Phenotype;Phosphatidic Acid;Positioning Attribute;Postdoctoral Fellow;programs;Proteins;Reporter;Research;SAM Domain;screening;Site;small molecule;Soft Tissue Neoplasms;Specific qualifier value;Specificity;structural biology;Surface;Surveys;symposium;System;targeted treatment;Testing;Therapeutic Index;Therapeutic Intervention;therapeutic target;therapy development;Tissues;Training;transcription factor;Transcription Repressor;Transcriptional Regulation;transcriptomics;transition mutation;tumor;tumorigenesis;Variant;Work;Xenograft Model;young adult

PROJECT_TITLE: Function and Targeting of ETV6 in Ewing Sarcoma

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Transition to Independence Study Section (I)[NCI-I]


ADMINISTERING_IC: GM

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: CHAPEL HILL

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative The quickening pace of scientific discovery demands a new generation of physician-scientists who can understand the languages that are spoken both in the research setting and at the bedside. Our plan is to provide rigorous scientific and clinical training in a safe and inclusive environment to train MD-PhD Physician-Scientists. Using this knowledge, these individuals will be ideally positioned to make significant contributions to and improvements in human health, and thereby become the next generation of leaders in biomedical science.

PI_NAMEs: DARVILLE, TONI ;DESHMUKH, MOHANISH P (contact)

PROGRAM_OFFICER_NAME: AKACEM, LAMEESE DANA

PROJECT_TERMS: Medical;Scientist;Training Programs

PROJECT_TITLE: UNC Medical Scientist Training Program

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - A[TWD-A]


ORG_CITY: BALTIMORE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: This grant award will support the Medical Scientist Training Program (MSTP) at the University of Maryland School of Medicine. The mission of our MSTP is to train a diverse and creative cadre of physician-scientists who will become leaders in their chosen fields of research, develop new knowledge and translate it to enhance clinical practice. This training will serve the nation by developing physician-scientists who can accelerate the progress of biomedical research from the laboratory to the direct benefit of patients.

PI_NAMEs: ROGHMANN, MARY-CLAIRE  (contact)

PROGRAM_OFFICER_NAME: FABIAN, MILES

PROJECT_TITLE: Medical Scientist Training Program


NIH_SPENDING_CATS: Cancer


ADMINISTERING_IC: OD

FUNDING_MECHANISM: OTHERS

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Clinical Research;Health Services;Precision Medicine

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PI_NAMEs: CLARK, CHERYL RENEE (contact);SMOLLER, JORDAN W

PROGRAM_OFFICER_NAME: ALTON, ANGELICA SUZETTE

PROJECT_TERMS: Advisory Committees;All of Us Research Program;Area;Biomedical Research;Boston;Cohort Studies;Collaborations;Communities;community advisory board;cost effective;cost efficient;data resource;design;Elements;Enrollment;Ensure;Equipment and supply inventories;Equity;evidence base;Health;Health Personnel;Health Surveys;Health system;Health Transition;high standard;Hospitals;improved;Individual;interest;Lead;Learning;Life;Longitudinal cohort study;Massachusetts;Measures;Medical center;member;Mental Health;Methods;Modeling;multimodality;New England;novel;novel strategies;operation;outreach;Participant;participant retention;Population;Population Heterogeneity;precision medicine;Procedures;Process;Process Measure;programs;Recommendation;recruit;Research;response;retention rate;Review Literature;safety net;Site;social health determinants;success;Testing;United States;United States National Institutes of Health;Update

PROJECT_TITLE: Supporting and sustaining engagement to retain strategies and disseminating research value in the All of Us Research Program


ADMINISTERING_IC: HL

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Clinical Research;Nanotechnology;Orphan Drug;Rare Diseases

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: PROJECT NARRATIVE An effective therapy with reduced risks and side effects for treating venous malformations is greatly needed. We propose to develop an intravenous drug delivery system comprised of very small (“nano”) particles that will convert to a tissue-targeting state when irradiated within venous malformations. By our strategy, the accumulation of drugs at the disease site will be enhanced while off-target drug delivery will be minimized.

PI_NAMEs: CULLION, KATHLEEN  (contact)

PROGRAM_OFFICER_NAME: WOO, SEUNG KYOON

PROJECT_TERMS: Binding;Blood Vessels;caged molecule;Cancer Biology;career;career development;Cells;Child;Complex;Development Plans;Disease;Drug Delivery Systems;Drug Targeting;effective therapy;Formulation;FRAP1 gene;Functional impairment;Funding;Goals;in vivo;Intravenous Drug Delivery Systems;irradiation;Lesion;Light;Mentors;Mentorship;nano;nanomedicine;nanoparticle;nanoparticle drug;nanoparticulate;Pain;particle;Pharmaceutical Preparations;Physicians;Research;Risk;Scientist;side effect;Sirolimus;Site;skill acquisition;Surface;systemic toxicity;targeted treatment;Technical Expertise;Techniques;Testing;Tissues;Training;Translational Research;Treatment Efficacy;tumor;uptake;Venous Malformation

PROJECT_TITLE: Supplement:  Developing Nanoparticle Drug Delivery Systems for Venous Malformations

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(MA)]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Mental Health;Neurosciences

ORG_CITY: NEW HAVEN

ORG_DEPT: NEUROSCIENCES

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: NARRATIVE  This proposal seeks to understand the role of tonic GABAergic signaling in shaping dendritic excitability within the neocortex. We combine an array of methods to monitor and manipulate neural activity in reduced preparations and in vivo. Results from these studies will identify cellular and circuit mechanisms by which GABAergic transmission promotes healthy brain function and provide important insights into how dysregulation of GABA signaling may contribute to neuropsychiatric disorders.

PI_NAMEs: HIGLEY, MICHAEL JAMES (contact)

PROGRAM_OFFICER_NAME: DRISCOLL, JAMIE DANIELLE

PROJECT_TERMS: Action Potentials;Acute;autism spectrum disorder;awake;Binding;Brain;Calcium;Calcium Channel;Calcium Signaling;cell type;Cells;Cellular biology;Chemosensitization;cognitive function;Computer Models;Data;data modeling;Dendrites;Development;Disease;Electrophysiology (science);Endocannabinoids;Epilepsy;experimental study;Functional disorder;GABA Receptor;gamma-Aminobutyric Acid;Generations;Glutamate Receptor;Goals;hippocampal pyramidal neuron;Hippocampus;Image;in vivo;insight;Interneurons;Investigation;Link;Long-Term Depression;Measurable;Mediating;Membrane;Methods;Molecular;Monitor;Mus;N-Methylaspartate;Neocortex;neocortical;neural;Neurodevelopmental Disorder;neuronal excitability;Neurons;neuropsychiatric disorder;optogenetics;Pattern;Pharmacology;Phase;postsynaptic;Preparation;Process;receptor;Receptor Activation;Rest;Rett Syndrome;Role;Schizophrenia;Shapes;Signal Pathway;Signal Transduction;Slice;Somatostatin;Source;Synapses;synaptic inhibition;Synaptic Transmission;tool;transmission process;two-photon;voltage gated channel;Work

PROJECT_TITLE: Cellular mechanisms of GABAergic inhibition in neocortical dendrites

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BN-P(57)]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Mental Health;Neurodegenerative;Neurosciences

ORG_CITY: GAINESVILLE

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Project Narrative Aging is associated with deficits in trust-related decision making, contributing to the growing public health problem of elder fraud. This project will (i) characterize basic neurocognitive processes in learning to trust in aging; and (ii) determine if trust-related decision making can be optimized via neurofeedback training.

PI_NAMEs: EBNER, NATALIE C (contact);LIGHTHALL, NICHOLE ;WILSON, ROBERT C

PROGRAM_OFFICER_NAME: SUTTERER, MATTHEW

PROJECT_TERMS: Address;Adult;Affective;Age;age related;age related neurodegeneration;Aging;aging related;Alzheimer's Disease;Amygdaloid structure;Anterior;Arizona;Basic Science;brain behavior;cingulate cortex;Clinical;Cognition Disorders;Cognitive;cognitive function;cognitive process;computational neuroscience;Computer Models;Control Groups;COVID-19 pandemic;Cues;Data;Decision Making;distrust;Elderly;Emotional;experience;experimental study;Family history of;Financial Hardship;Florida;Foundations;Fraud;Functional Magnetic Resonance Imaging;Future;Gambling;Geriatric Assessment;Goals;Health;healthy aging;Human;human old age (65+);Impaired cognition;Impairment;improved;Individual;innovation;Insula of Reil;interdisciplinary approach;Intervention;Investigation;Iowa;Learning;Life;life span;Link;Measures;Mediating;Memory;Methodology;middle age;neural;neural circuit;neural correlate;Neurocognitive;neuroeconomics;neurofeedback;neuroimaging;neuromechanism;Neuropsychology;neurotransmission;novel;older adult;Older Population;Outcome;Pathology;Pathway interactions;phishing;Play;pre-clinical;Predisposition;Process;Public Health;Research;Research Project Grants;response;Risk;Role;Sampling;Signal Transduction;social;Social Interaction;Social Sciences;Societies;System;Techniques;Testing;theories;theory of mind;Time;Training;translational potential;Trust;trustworthiness;Up-Regulation;Update;Work;young adult

PROJECT_TITLE: Characterizing and modulating neurocognitive processes of learning to trust and distrust in aging

STUDY_SECTION: HCMF

STUDY_SECTION_NAME: Human Complex Mental Function Study Section[HCMF]


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases

ORG_CITY: CHAMPAIGN

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

ORG_STATE: IL

PHR: PROJECT NARRATIVE Human antibodies are highly diverse and can recognize a wide range of epitopes to confer protection against different pathogens. The epitope specificity of an antibody is determined by its structure, which is in turn determined by its primary amino acid sequence. This proposal aims to develop a novel experimental platform to characterize antibody-antigen interactions in a high-throughput manner and identify molecular features that can help predict the epitope of an antibody based on its sequence.

PI_NAMEs: WU, NICHOLAS C. (contact)

PROGRAM_OFFICER_NAME: KIM, HYE-SOOK

PROJECT_TERMS: Affinity;Amino Acid Sequence;Antibodies;Antibody Diversity;Antibody Repertoire;Antibody Specificity;Antigens;Base Sequence;Binding;Data Set;Epitopes;experimental study;Genes;Genetic Recombination;Hemagglutinin;Human;Immune response;Immune system;Immunoglobulin Somatic Hypermutation;Influenza A virus;Influenza Hemagglutinin;interest;Libraries;Molecular;Molecular Conformation;novel;pathogen;Process;screening;Specificity;Structure;therapeutic development;V(D)J Recombination;vaccine development

PROJECT_TITLE: High-throughput identification of antibody features for sequence-based epitope prediction


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Diabetes;Emerging Infectious Diseases;Health Services;Infectious Diseases;Nutrition;Patient Safety;Pediatric;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID;Prevention

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Project Narrative Recent studies have found that infection with SARS-CoV-2 and COVID-19 diagnosis are associated with the development and progression of both Type 1 (T1D) and Type 2 Diabetes (T2D). The proposed study will engage 15 sites from the National Patient-Centered Clinical Research Network (PCORnet) and the T1D Exchange to recruit 1600 English- and Spanish-speaking pediatric and adult patients with recently diagnosed T1D or T2D who have had a known COVID-19 infection in the past 90 days or no recent diagnosis of COVID- 19 infection in the past year. The study will follow this population for 2 years and will utilize linked electronic health data from PCORnet sites to understand the impact of COVID-19 on diabetes.

PI_NAMEs: BLOCK, JASON PERRY;POWERS, ALVIN C;ROTHMAN, RUSSELL L. (contact);SCHILDCROUT, JONATHAN SCOTT

PROGRAM_OFFICER_NAME: MALOZOWSKI, SAUL N

PROJECT_TERMS: 2019-nCoV;Adult;American;Antibodies;Area;Beta Cell;Biological Markers;Biological Process;Blood Vessels;CDC42 gene;Cell Physiology;Cessation of life;Child;Childhood;Childhood diabetes;Clinical;Clinical Research;cohort;community engagement;Consent;COVID-19;COVID-19 diagnosis;COVID-19 impact;COVID-19 pandemic;COVID-19 patient;COVID-19 sequelae;COVID-19 surveillance;COVID-19 test;COVID-19 treatment;Data;data hub;Deterioration;Development;Diabetes Mellitus;Diagnosis;drug repurposing;electronic health data;Electronic Health Record;Environmental Risk Factor;Epidemiology;epidemiology study;experience;Family;Fibrosis;Funding;Future;Genomics;Glucose tolerance test;glycemic control;Health;Health Services Research;Health system;improved;Individual;Infection;Inflammation;Informatics;Infrastructure;Insulin Resistance;Insulin-Dependent Diabetes Mellitus;Internet;Intervention;Intervention Studies;Link;Long COVID;member;Metabolic;metabolomics;Multicenter Trials;Non-Insulin-Dependent Diabetes Mellitus;Nucleocapsid;Obesity;Observational Study;Outcome;Outpatients;pandemic disease;Participant;patient oriented;patient portal;patient registry;patient subsets;Patients;Physiological;Physiology;Population;Post-Acute Sequelae of SARS-CoV-2 Infection;Process;Public Health;Records;recruit;Registries;Research;Resources;Risk;Role;SARS-CoV-2 exposure;SARS-CoV-2 infection;SARS-CoV-2 negative;Serology test;Site;social;Spanish/English;Standardization;Structure;Study Subject;Surveys;Telephone;Testing;Thrombophilia;Time;type 2 diabetes in children;type I and type II diabetes;United States National Institutes of Health;Work

PROJECT_TITLE: CODA: COvid and Diabetes Assessment


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Arthritis;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Neurodegenerative;Neurosciences;Osteoarthritis;Pain Research;Patient Safety;Peripheral Neuropathy

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PI_NAMEs: FAVA, MAURIZIO  (contact)

PROGRAM_OFFICER_NAME: HOMMER, REBECCA EVE

PROJECT_TERMS: Absence of pain sensation;Acute Pain;addiction;Address;Adult;Affect;Aftercare;Analgesics;antagonist;Asia;Award;Barbiturates;Behavioral;bench to bedside;beta-Chemokines;Biological;Biological Markers;Blood specimen;Characteristics;chronic pain;Clinical;clinical application;clinical investigation;clinical predictors;Clinical Research;clinical research site;Clinical Trials;Clinical Trials Network;clinically relevant;Collection;Common Data Element;Cream;Data Collection;Data Set;density;design;Devices;Diabetes Mellitus;diabetic;Dose;Double-Blind Method;early phase clinical trial;effective therapy;efficacy evaluation;Elderly;Elements;Enrollment;Europe;Exhibits;experience;FDA approved;foot;Functional disorder;Funding;Gastric ulcer;Genotype;Growth;Helping to End Addiction Long-term;Hospitals;Hour;Hypersensitivity;Individual;Inflammatory;inflammatory marker;Infrastructure;Injections;interest;Intervention;Joints;Knee Osteoarthritis;Laboratory Finding;Length of Stay;Marketing;Measurement;Measures;men;microbiome analysis;Modernization;Natural Substance;Nerve;Nerve Fibers;neuroinflammation;Neurosecretory Systems;neurotransmission;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutics;Operative Surgical Procedures;Opioid;opioid exposure;opioid overdose;opioid use;Oral;osteoarthritis pain;Outcome;Pain;Pain management;pain model;pain relief;Pain Research;painful neuropathy;Participant;Patients;Peripheral Nervous System Diseases;Persons;Pharmaceutical Preparations;Phase;Phase II Clinical Trials;Phenotype;Pirenzepine;Placebo Control;placebo controlled study;Placebos;preclinical study;predicting response;predictive marker;Procedures;Prognostic Marker;Protocols documentation;psychological distress;Randomized;receptor;Recording of previous events;Research;response biomarker;Risk;Safety;safety assessment;Sampling;Secure;Sensory;sex;Siberia;Site;Skin;small molecule;sociodemographics;stem;Structure;Tea;Testing;Therapeutic;therapeutic development;therapeutic evaluation;Time;Topical application;Touch sensation;Transcranial Doppler Ultrasonography;translational medicine;trial design;ultrasound;United States National Institutes of Health;Vasospasm;Woman

PROJECT_TITLE: EPPIC-Net Pain Research - Application for Clinical Trial and Related Activities (OT2)


NIH_SPENDING_CATS: Clinical Research;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza

ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: NARRATIVE Neutrophils are white blood cells that kill the pathogens in infected tissue. We believe that this antibacterial function of neutrophils is activated by mechanical forces these cells experience as they migrate through vascular endothelial junctional barrier into infected tissue. The research will help us understand how the tension sensed by transmigrating neutrophil “educates” neutrophils to fight with tissue pathogens and hopefully lead to better treatments for patients with bacterial infection.

PI_NAMEs: KOMAROVA, YULIA A;MALIK, ASRAR B. (contact)

PROGRAM_OFFICER_NAME: ZHOU, GUOFEI

PROJECT_TERMS: Address;Adherens Junction;Anti-Bacterial Agents;antimicrobial;Bacteria;Bacterial Infections;Calcium;cell killing;Cells;Cues;Data;Diameter;Endothelium;Exhibits;experience;experimental study;Family member;fighting;fungus;gain of function;Generations;Genes;genetic analysis;genetic approach;Genetic Transcription;Goals;Health;Heterogeneity;HIF1A gene;Host Defense;Human;improved;In Vitro;in vivo;Infection;Inhalant dose form;innate immune mechanisms;Invaded;Ion Channel;Irritants;Knockout Mice;Lead;Leukocytes;Link;Lung;Lung infections;Lytic;mechanical force;Mediating;Membrane;migration;Modeling;Molecular;mutant;NADPH Oxidase;neutrophil;Organelles;Oxidation-Reduction;pathogen;Patients;Phagocytosis;Phagolysosome;Phagosomes;pharmacologic;Phenotype;Piezo 1 ion channel;Play;pneumonia model;Process;programs;Property;Proteolysis;Pseudomonas aeruginosa pneumonia;Reactive Oxygen Species;Regulation;Research;Resolution;Role;Seminal;Signal Pathway;Signal Transduction;Structure of parenchyma of lung;System;Testing;Therapeutic;Time;Tissues;Toxin;Up-Regulation;Vascular Endothelium

PROJECT_TITLE: Programming of PMN host-defense function during transendothelial migration

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


NIH_SPENDING_CATS: Autoimmune Disease;Behavioral and Social Science;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Pediatric;Prevention

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE Advanced management of children with type 1 diabetes (T1D) aims to utilize diabetes devices, such as insulin pumps (IP) and continuous glucose monitors (CGM), to optimize glycemic control; however, use of these devices has not resulted in the expected improvements in T1D outcomes. We will identify unmet psychoeducational needs in parents of children using IP and CGM to manage T1D and leverage this information to inform a feasibility and acceptability study assessing an app-delivered psychoeducational intervention intended to improve knowledge and alter behaviors related to diabetes technology use. Successful execution of this project will inform a future randomized controlled trial that will demonstrate the efficacy of an easily distributed psychoeducational tool that will help to realize the full potential of diabetes technologies while also providing Dr. Marks with the training and mentorship needed to transition to an independent physician scientist.

PI_NAMEs: MARKS, BRYNN E (contact)

PROGRAM_OFFICER_NAME: THORNTON, PAMELA L

PROJECT_TERMS: 12 year old;acceptability and feasibility;Acute;Address;Adult;Advisory Committees;assessment application;Behavior;Behavior Therapy;Behavioral;career development;Caring;Child;Child Care;Childhood;Chronic;Clinical;clinical practice;Continuous Glucose Monitor;Controlled Clinical Trials;Data;design;Development;Devices;diabetes educator;diabetes management;Diabetes Mellitus;diabetes self-management;early adolescence;Education;education research;Educational Curriculum;Educational process of instructing;Educational Technology;eligible participant;Endocrinology;Evaluation;experience;Family;Future;glycemic control;Goals;Growth and Development function;health related quality of life;Hemoglobin;improved;improved outcome;Incidence;Individual;innovation;Instruction;Insulin Infusion Systems;Insulin-Dependent Diabetes Mellitus;Intervention;Interview;K-Series Research Career Programs;Knowledge;Knowledge acquisition;Leadership;Learning;Learning Skill;Medical;Medical Education;Mentors;Mentorship;Methodology;motivational enhancement therapy;Multicenter Studies;Needs Assessment;Non-Insulin-Dependent Diabetes Mellitus;novel;Outcome;parental monitoring;Parents;patient oriented;Patients;Persons;Physicians;preadolescence;prevent;Problem Solving;Process;Provider;psychoeducation;psychoeducational intervention;Qualitative Research;Quality of life;Randomized, Controlled Trials;recruit;Research;Research Personnel;research study;Sampling;satisfaction;School-Age Population;Scientist;Semantics;skills;Standardization;Techniques;Technology;Testing;Time;tool;Training;Translating;uptake;Youth

PROJECT_TITLE: Developing a patient-centered psychoeducational tool to realize the potential of diabetes technologies

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


NIH_SPENDING_CATS: Infectious Diseases;Rare Diseases

ORG_CITY: SYRACUSE

ORG_NAME: UPSTATE MEDICAL UNIVERSITY

ORG_STATE: NY

PHR: Project Narrative The proton-pumping vacuolar ATPase (V-ATPase; V1Vo-ATPase) is a multisubunit enzyme complex that is responsible for vital cellular functions in all eukaryotic organisms and which is linked to several devastating human diseases such as renal tubular acidosis, osteopetrosis, diabetes, neurodegeneration, cancer, and microbial and viral infections. This proposal requests funds for obtaining high-resolution structural information for active holo V-ATPase and its autoinhibited proton channel subcomplex in lipid nanodiscs to study inhibitor binding and for elucidating V-ATPase's unique mode of regulation, for elucidating biochemical properties of specific isoform containing human V-ATPase, and to develop single-domain antibodies directed against yeast and human V-ATPase subunit isoforms as a novel tool for studying V-ATPase's structure and regulatory mechanisms. The long-term goal of the project is to gain a molecular understanding of the enzyme's role in human disease, and to identify novel ways to modulate the activity of disease causing V-ATPase in a subunit isoform and tissue specific manner.

PI_NAMEs: WILKENS, STEPHAN  (contact)

PROGRAM_OFFICER_NAME: MACARTHUR, LINDA

PROJECT_TERMS: Acid-Base Equilibrium;Acids;Address;Albers-Schonberg disease;ATP phosphohydrolase;Binding;Biochemical;Biochemistry;Biological Models;Biophysics;Bone remodeling;Cell Physiology;Cell secretion;Cells;Cellular biology;Complex;Diabetes Mellitus;Disease;Dissociation;Embryo;Endocytosis;Environment;Enzymes;Eukaryotic Cell;Extracellular Space;fighting;Funding;Goals;Human;human disease;human tissue;Hyperactivity;in vitro Model;Infection;Influenza;inhibitor;interest;Knowledge;Laboratories;Link;Lipids;Male Infertility;Malignant Neoplasms;Membrane;microbial;Molecular;Motor;mRNA Differential Displays;Multienzyme Complexes;mutant;nanobodies;nanodisk;Nerve Degeneration;neurotransmitter release;novel;Organelles;Organism;Physiology;Process;programs;Property;Protein Isoforms;protein transport;Proton Pump;Protons;Regulation;Renal tubular acidosis;Request for Proposals;Research;Resolution;Role;Sperm Maturation;structural biology;Structure;System;targeted treatment;tissue culture;Tissues;tool;Up-Regulation;vacuolar H+-ATPase;Virus;Virus Diseases;Yeasts

PROJECT_TITLE: A cryo-box for a 200 kV TEM


FUNDING_MECHANISM: RESEARCH CENTERS

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative

ORG_CITY: TEMPE

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

ORG_STATE: AZ

PI_NAMEs: LANGBAUM, JESSICA BROOKE (contact)

PROGRAM_OFFICER_NAME: ELLIOTT, CERISE

PROJECT_TITLE: Core A: Administrative Core


PI_NAMEs: ATRI, ALIREZA  (contact)

PROJECT_TITLE: Core B: Clinical Core


PI_NAMEs: SU, YI  (contact)

PROJECT_TITLE: Core C: Data Management and Statistics Core (DMSC)


PI_NAMEs: BEACH, THOMAS G (contact)

PROJECT_TITLE: Core D: Neuropathology Core


PI_NAMEs: COON, DAVID W (contact)

PROJECT_TITLE: Core E: Outreach, Recruitment, and Engagement Core


PI_NAMEs: ALEXANDER, GENE E (contact)

PROJECT_TITLE: Core F: Biomarker Core


PI_NAMEs: BRINTON, ROBERTA EILEEN (contact)

PROJECT_TITLE: Research Education Component


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Lung;Pediatric;Rare Diseases;Tuberculosis

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: Modified Public Health Relevance Section Adolescents may be drivers of local tuberculosis transmission; they are a unique population due to their dynamic cognitive, psychological, and physical changes, and they can spread tuberculosis through their expanding social networks. A more robust understanding of tuberculosis epidemics will be gained through the proposed research by using geographic information and tuberculosis strain types to identify individual-, household- and population-level drivers of tuberculosis spread in adolescents. Our study will elucidate important person, place, and time interactions of tuberculosis in adolescents to inform how to best deploy tailored interventions to reduce tuberculosis spread in communities.

PI_NAMEs: BROOKS, MEREDITH BLAIR (contact)

PROGRAM_OFFICER_NAME: MENDEZ, SUSANA

PROJECT_TERMS: 14 year old;19 year old;Adolescence;Adolescent;Adult;Award;Bayesian Modeling;Calibration;career development;Characteristics;Child;Childhood;Cognitive;Communities;community transmission;Computer Models;Data;Data Science;Development Plans;Disease;Epidemic;Epidemiology;Event;experience;genome sequencing;Genotype;Geography;Goals;Heterogeneity;high risk population;Household;Incidence;Individual;Infection;Influentials;insight;Intervention;Knowledge;Location;Machine Learning;Maps;member;Mentors;Mentorship;Methods;Minisatellite Repeats;Modeling;neglect;novel;Pattern;Persons;Peru;Population;Preventive treatment;psychologic;public health relevance;Pulmonary Tuberculosis;random forest;Reporting;Research;Research Project Grants;Scholarship;Science;Scientist;screening;simulation;social;social contact;Social Network;Spatial Distribution;spatiotemporal;symposium;Techniques;Teenagers;Testing;Time;Training;transmission process;trend;Tuberculosis;tuberculosis treatment;Visualization;whole genome;Work

PROJECT_TITLE: Tuberculosis in teens: a geospatial approach to predict community transmission

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases Advisory Committee[MID]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Health Services;Neurodegenerative;Neurosciences;Prevention;Primary Health Care

ORG_CITY: AUSTIN

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

ORG_STATE: TX

PHR: Parent Project Narrative This project will facilitate early detection of cognitive decline in older adults through development and implementation of an automated risk assessment and cognitive screening tool for use in primary care. By providing an automated tool developed specifically to address the needs of PCPs, it will be easier to screen for cognitive impairment, increasing the number of older adults who are screened and thus identified and treated.

PI_NAMEs: CHANG, JOSHUA TSUKANG (contact);HILSABECK, ROBIN C

PROGRAM_OFFICER_NAME: KIM, THERESA YOUNGJOO

PROJECT_TERMS: Acoustics;Address;Administrative Supplement;aged;Alzheimer disease detection;Alzheimer's Disease;Alzheimer's disease related dementia;analysis pipeline;Assessment tool;Benefits and Risks;bilingualism;Blood Pressure;Characteristics;Cholesterol;Classification;Clinic;Clinical;Cognition Disorders;Cognitive;cognitive enhancement;cognitive testing;Communication;cost;Dementia;Development;Diagnosis;Early Diagnosis;Early identification;Electronic Health Record;electronic health system;eligible participant;Ethnic Origin;Exclusion Criteria;Exhibits;Exposure to;Family;Female;functional decline;Goals;Health;Impaired cognition;Individual;Instruction;Intervention;Knowledge;Label;Language;Latinx;Linguistics;male;Measurement;Medical Records;Medicare;Memory;Methods;mild cognitive impairment;motor impairment;Neuropsychological Tests;older adult;parent project;Parents;Participant;participant enrollment;patient population;Patients;Pharmaceutical Preparations;Phase;Policies;Preventive healthcare;Primary Care;primary care clinic;primary care provider;primary care setting;Procedures;Questionnaires;Race;rate of change;reading difficulties;Recommendation;recruit;Reporting;Research;Risk Assessment;Sampling;screening;Screening procedure;Short-Term Memory;Site;Spanish;Spanish/English;Testing;Texas;Thinking;Time;tool;Translating;United States National Institutes of Health;Universities;usability;Visual Acuity;Voice;Wellness Center;wellness visit

PROJECT_TITLE: Cognitive Screening Made Easy for Primary Care Providers


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: ATLANTA

ORG_DEPT: PEDIATRICS

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE We have developed a non-infectious, self-replicative SARS-CoV-2 replicon system that is a safe and effective tool for antiviral screening and amenable to genetic engineering for studying drug resistance. We have identified a small molecule inhibitor of SARS-CoV-2 antiviral activity, and early medicinal chemistry efforts have optimized this lead. This project aims to further identify and characterize compounds toward the development of novel inhibitors against SARS-CoV-2 with potent, nanomolar antiviral activity.

PI_NAMEs: SARAFIANOS, STEFAN G (contact);WANG, ZHENGQIANG

PROGRAM_OFFICER_NAME: BASU, DIPANWITA

PROJECT_TERMS: 2019-nCoV;Active Sites;Address;Affect;Air;airway epithelium;analog;Anti-viral Agents;Binding;Biochemical;Biological Assay;Biophysics;Caco-2 Cells;Cell Line;cell preparation;Cells;Cessation of life;Collection;combat;Combined Modality Therapy;Coronavirus;COVID-19;COVID-19 mortality;cytotoxicity;Data;Development;Disclosure;Disease;Disease Outbreaks;drug candidate;drug discovery;Drug Kinetics;Drug resistance;Effectiveness;efficacy study;Enzyme Kinetics;experimental study;expression cloning;fitness;Fluorescence Microscopy;Generations;Genes;Genetic Engineering;Genomics;Grant;helicase;Hepatitis B Virus;Hepatitis C virus;high throughput screening;HIV-1;HIV-2;Human;improved;In Vitro;in vivo;Individual;Influenza;inhibitor;innovation;International;invention;Kinetics;Lead;lead optimization;Legal patent;Libraries;Liquid substance;Measurement;Measures;Metals;meter;miniaturize;Molecular;monolayer;mortality;mouse model;Mus;Mutation;nanomolar;Nonstructural Protein;novel;pandemic disease;Pharmaceutical Chemistry;Plasmids;Preparation;Proteins;Public Health;Published Comment;Publishing;remdesivir;Replicon;Reporting;Resistance;resistance mechanism;resistance mutation;RNA;SARS coronavirus;SARS-CoV-2 antiviral;SARS-CoV-2 B.1.1.7;SARS-CoV-2 B.1.351;SARS-CoV-2 CAL.20C;SARS-CoV-2 inhibitor;SARS-CoV-2 P.1;screening;Severe Acute Respiratory Syndrome;small molecule inhibitor;small molecule libraries;socioeconomics;stable cell line;success;synergism;System;Technology;Testing;Time;tool;Transfection;Untranslated Regions;Vaccines;Variant;Viral;viral entry inhibitor;Viral Physiology;Virus;Virus Diseases;Visualization;Washington;Work;ZIKA

PROJECT_TITLE: Discovery of SARS-CoV-2 antivirals using a replicon assay

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AIDC-V(02)]


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Clinical Research;Infectious Diseases;Women's Health Research

ORG_DEPT: OBSTETRICS & GYNECOLOGY

PHR: NARRATIVE This program builds upon the highly successful UJMT Fogarty Global Health Fellowship, now in its tenth year. Its cornerstone is a 12-month, mentored research training opportunity at one of 30 institutions across Africa, Asia, and the Americas. We further strengthen the program with an innovative curriculum on research leadership, new approaches to enhance diversity in global health, and research platforms aligned with regional and international scientific priorities.

PI_NAMEs: CHECKLEY, WILLIAM ;CHI, BENJAMIN H. (contact);KONDWANI, KOFI A;OBERHELMAN, RICHARD A

PROGRAM_OFFICER_NAME: HAYES, UNJA

PROJECT_TERMS: Academy;Active Learning;Address;Area;Award;base;career;Child Health;Collaborations;Communicable Diseases;Country;Critical Pathways;Development Plans;Disease;Educational Curriculum;Environmental Health;experience;Fellowship;Fostering;Funding;Future;global health;Government Programs;Grant;HIV/AIDS;improved;Individual;Institution;International;Investments;Leadership;Learning;Malignant Neoplasms;Manuscripts;Mental Health;Mentors;Monitor;Morehouse School of Medicine;Nervous System Disorder;North Carolina;Performance;Positioning Attribute;Postdoctoral Fellow;Process;Productivity;programs;Publishing;recruit;Research;Research Methodology;Research Personnel;Resources;Secure;Site;skills;Talents;Training;training opportunity;Training Programs;Underrepresented Populations;United States National Institutes of Health;Universities;Women's Health;Writing

PROJECT_TITLE: UJMT – ORWH – Gazzetta, Issa-Boube


PROJECT_TITLE: UJMT – OBSSR – Charles-Stijnberg, Nakanga


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Behavioral and Social Science;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: EUGENE

ORG_NAME: UNIVERSITY OF OREGON

ORG_STATE: OR

PHR: Project Narrative This project will study the interaction between cortical and subcortical structures in identifying behaviorally relevant features in complex auditory and visual input. This is a fundamental aspect of sensory processing, and elucidating the neural circuit and computational mechanisms will support potential therapies for deafness and blindness.

PI_NAMEs: NIELL, CRISTOPHER M (contact);WEHR, MICHAEL

PROGRAM_OFFICER_NAME: DAVID, KAREN KATE

PROJECT_TERMS: Auditory;Auditory Physiology;Behavior;Behavioral;Blindness;Brain;Code;Collaborations;Complex;computer studies;Data;deafness;detector;Environment;Ethology;experimental study;extracellular;flexibility;Head;Measures;Mediating;Modality;Mus;neural;neural circuit;Ocular Physiology;Recording of previous events;response;Role;Sensory;sensory cortex;Site;Stimulus;Structure;superior colliculus Corpora quadrigemina;System;Testing;Visual

PROJECT_TITLE: The interaction of cortical and subcortical processing in natural sensory behavior


NIH_SPENDING_CATS: Bioengineering;Building Research Capacity at Institutions with Limited NIH Funding;Infectious Diseases

ORG_CITY: LAWRENCE

ORG_NAME: UNIVERSITY OF KANSAS LAWRENCE

ORG_STATE: KS

PI_NAMEs: OROZCO, ROBIN C. (contact)

PROGRAM_OFFICER_NAME: BERNAL, FEDERICO

PROJECT_TERMS: Aerosols;Bacteria;Biological Assay;Biology;biosafety level 2 facility;Cell fusion;Cell Separation;Cells;Centers of Research Excellence;Characteristics;Chemicals;Color;Communicable Diseases;Computer software;Cytometry;Data;data acquisition;Data Analyses;density;design;Detection;Development;Emergency Situation;Equipment;experimental study;Faculty;Flow Cytometry;Fluorochrome;Generations;Goals;Grant;Hour;Human Resources;immune activation;Immune response;Immunologic Monitoring;Individual;Infection;Infectious Agent;Infectious Diseases Research;instrument;instrumentation;Kansas;Laboratories;Lasers;Licensing;light scattering;Manuscripts;Measurement;Measures;Methods;Multiparametric Analysis;Parasites;pathogenic microbe;Phenotype;Population;Privatization;Reagent;Research;Research Personnel;Resources;response;Robin bird;Running;Sampling;Secure;Services;Site;Sorting;System;tool;Training;Tube;Universities;user protection;virtual

PROJECT_TITLE: Flow Cytometry Research Core


NIH_SPENDING_CATS: Neurosciences;Nutrition;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Project Narrative: Neurodevelopmental disorders, including microcephaly and autism, as well as neurodegenerative diseases, including Alzheimer’s, and cancer result in significant human suffering and impose significant annual costs on the US health care system and society as a whole. This proposal seeks to understand how diet influences neural stem cell proliferation decisions during development. Neural stem cells are the cells that make all the neurons in the brain. Results garnered from this research will stimulate new discoveries in translational stem cell research in the context of normal development and disease states.

PI_NAMEs: SIEGRIST, SARAH ELIZABETH (contact)

PROGRAM_OFFICER_NAME: XU, JIANHUA

PROJECT_TERMS: Adult;Affect;Alzheimer's Disease;autism spectrum disorder;Behavior;Brain;Cell division;cell type;Cells;Complex;Consumption;cost;Dependence;Development;Diet;dietary;Disease;Drosophila genus;Drosophila melanogaster;Genetic;Goals;Healthcare Systems;Human;insight;Intrinsic factor;Learning;Location;Malignant Neoplasms;Maps;mature animal;Memory;Microcephaly;model organism;Molecular;Morphology;nerve stem cell;neural circuit;neuroblast;Neurodegenerative Disorders;Neurodevelopmental Disorder;Neurons;neuroregulation;Nutrient;Nutrient availability;Pathway interactions;PIK3CG gene;Population Heterogeneity;programs;Proliferating;Research;response;Series;single cell sequencing;Societies;Specific qualifier value;stem cell proliferation;Stem Cell Research;Techniques;Time;transcription factor

PROJECT_TITLE: Nutrient-dependent regulation of neural stem cell proliferation and neural circuit formation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


ADMINISTERING_IC: ES

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Endocrine Disruptors;Estrogen;Prevention;Social Determinants of Health

ORG_CITY: EL CERRITO

ORG_NAME: MILLION MARKER WELLNESS INC.

ORG_STATE: CA

PHR: Public Health Relevance Statement Million Marker is the first company to provide tools and services that allow people to understand their personal environmental chemical exposures (i.e. endocrine disrupting chemicals, EDCs) in order to prevent diseases and optimize their health by changing their lifestyle choices. This work aims to develop an affordable and scalable intervention program, with interactive curriculum and individualized support, that can be readily disseminated and commercialized to help customers reduce exposures to EDCs. Completion of this proposal will allow Million Marker to offer EDC testing and intervention to the general public, thus taking steps to address this global health crisis.

PI_NAMEs: HUA, JENNA  (contact)

PROGRAM_OFFICER_NAME: SHAUGHNESSY, DANIEL

PROJECT_TERMS: Address;Adult;Age;Analytical Chemistry;arm;Asthma;Awareness;Back;Behavioral;Biological Markers;Biological Monitoring;Biometry;Businesses;Chemical Exposure;chemical reduction;Chemicals;child bearing;Chronic Disease;Clinic;Clinical;clinical care;cohort;commercialization;compare effectiveness;cost effective;Counseling;crowdsourcing;curriculum development;Curriculum Management System;Data Engineering;Diabetes Mellitus;diabetes prevention program;digital;digital intervention;Disease;Economic Burden;Educational Curriculum;effectiveness testing;empowerment;Endocrine Disruptors;environmental chemical;environmental chemical exposure;Environmental Epidemiology;Environmental Exposure;Environmental Health;experience;Exposure to;Female;Female of child bearing age;Fertility;Fetus;General Population;Genetic;genetic testing;global health;Health;health literacy;healthy lifestyle;human centered design;Hypersensitivity;Hypospadias;improved;Individual;Infertility;instrument;Insurance Coverage;Intervention;intervention program;Knowledge;Learning;Letters;Life Style;Link;literacy;Low Birth Weight Infant;male;Malignant Breast Neoplasm;Marketing;Measures;men;Metabolic syndrome;Mission;mobile application;Modeling;multidisciplinary;Nevada;online intervention;Outcome;Outcome Assessment;Parabens;Participant;Patient Recruitments;Patients;Personal Satisfaction;Persons;Phase;phase 1 study;phthalates;Population;population health;Positioning Attribute;post intervention;Precision Health;precision medicine;Predisposition;Pregnancy;Premature Birth;prevent;Process;programs;public health relevance;Randomized;Randomized, Controlled Trials;Readiness;recruit;Reporting;reproductive;Research;response;Sampling;satisfaction;Science;Scientist;Self Direction;service intervention;Services;Surveys;System;Target Populations;Testing;testing services;tool;Toxicology;Training;treatment arm;trend;Urine;usability;Vision;Well in self;Woman;Work

PROJECT_TITLE: A Personalized Digital Intervention Program to Reduce Exposure to Endocrine Disrupting Chemicals among a Child-Bearing Age Cohort

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(10)-B]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Mental Illness;Neurosciences

PHR: Project Narrative: The proposed research is relevant to public health because it will advance the toolkit used in discovery science for high yield early phase target validation and therapeutic screening for the development of new treatments for mental health disorders. By understanding how local impairments alter systems-level network function in relation to a clinically relevant cognitive test used for human neuropsychological assessment, it will be possible to promote the development of interventions that improve the health and wellbeing of individuals with mental illness and meet the mission of the NIMH.

PI_NAMEs: BURKE, SARA N;MAURER, ANDREW PORTER (contact)

PROGRAM_OFFICER_NAME: HUPALO, SOFIYA

PROJECT_TERMS: Address;Affect;Affective;analog;Animal Model;Animals;Anxiety;autism spectrum disorder;Behavior;Behavior assessment;behavior measurement;Behavioral;behavioral outcome;Biological Assay;Biological Markers;Bipolar Disorder;Brain;cholinergic;Clinical;Clinical Trials;clinically relevant;Cognition;cognitive function;cognitive process;cognitive testing;Communication;comparative;Coupling;Data;density;design;designer receptors exclusively activated by designer drugs;Development;diagnostic tool;drug discovery;drug efficacy;drug testing;Elderly;Electroencephalography;emotion regulation;Evaluation;experimental study;Failure;Foundations;Funding;Funding Opportunities;Goals;Health;Heart Diseases;high throughput screening;Hippocampus;Human;Impaired cognition;Impairment;improved;in vivo;Individual;innovation;Knowledge;Link;Malignant Neoplasms;Mammals;Measures;mental development;Mental disorders;Mission;Modeling;National Institute of Mental Health;neural;Neurobiology;Neurons;neurophysiology;Neuropsychological Tests;Neuropsychology;Neurotransmitters;novel;novel diagnostics;novel therapeutics;Outcome;Paired-Associate Learning;Parietal;Performance;Personal Satisfaction;pharmacologic;Pharmacologic Substance;Pharmacological Treatment;Phase;Physiological;pre-clinical;predictive marker;Prefrontal Cortex;Psychiatric therapeutic procedure;Psychiatry;Public Health;Research;Rodent;Schizophrenia;Science;screening;Screening procedure;Series;Severities;Severity of illness;Surface;System;Task Performances;Technology;Temporal Lobe;Testing;Therapeutic;therapeutic development;therapeutic target;therapy development;touchscreen;Translating;Traumatic Brain Injury;treatment optimization;Validation

PROJECT_TITLE: Preclinical Assays of Hippocampal-Prefrontal Cortical Circuit Engagement for Application in Therapeutic Development

STUDY_SECTION: PMDA

STUDY_SECTION_NAME: Pathophysiological Basis of Mental Disorders and Addictions Study Section[PMDA]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: PITTSBURGH

ORG_NAME: VETERANS HEALTH ADMINISTRATION

PHR: VA medical centers are frequently challenged when attempting to safely transfer VwD when being treated in medical centers, extended care, or long-term care. There are rooms with overhead lifts, and crane lifts are available, but the number of injuries to staff remains high. Solutions are needed that can be re-used sequentially by multiple veterans in a facility and moved from room to room as needed; and that could also be used long-term by VwD in a VA facility or a VwD's home. This project's focus on EPW users is relevant to individuals within the VA's special disability programs which are high priority. The VA Patient Care Mission stresses providing Prosthetic and Sensory Aides (beds and wheelchairs) to improve veterans' health and well-being. This research can potentially improve safety, function, and quality of assist devices for bed/EPW transfers, and the quality of life and community participation for many veterans.

PI_NAMEs: COOPER, RORY A. (contact)

PROJECT_TERMS: Algorithms;analog;Automation;Beds;Benchmarking;Caregivers;Clinical;Communication;Community Participation;Computer software;cost;Custom;Data;Data Collection;data sharing;Databases;design;Development;Devices;disability;Disabled Persons;Docking;Environment;Esthetics;Evaluation;Fatigue;Floor;Focus Groups;Funding;Head;Health;Healthcare;Home;hospital bed;Immobilization;improved;improved mobility;Individual;Injury;interest;invention;Laboratories;Legal patent;Licensing;Lifting;Long-Term Care;Lower Extremity;Manual wheelchair;Marketing;Mechanics;Medical center;Mission;mobility aid;Outcome;Participant;Patient Care;Patients;Penetration;Performance;Personal Satisfaction;Persons;Price;Process;programs;Prosthesis;prototype;Provider;Quality of life;Rehabilitation therapy;Research;research and development;Safety;satisfaction;Self-Help Devices;Sensory;Specific qualifier value;stability testing;Stress;Structure;success;Sum;Surveys;System;Technology;Testing;tool;Translating;United States National Aeronautics and Space Administration;Upper Extremity;usability;Veterans;Visual;Wheelchairs;wireless;Work

PROJECT_TITLE: Powered Person Transfer System

STUDY_SECTION_NAME: Rehabilitation Engineering & Prosthetics/Orthotics [RRD5]


NIH_SPENDING_CATS: Autoimmune Disease;Data Science;Estrogen;Rare Diseases;Scleroderma

ORG_CITY: HANOVER

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PI_NAMEs: WHITFIELD, MICHAEL L (contact)

PROGRAM_OFFICER_NAME: MCGUIRL, MICHELE

PROJECT_TERMS: Address;Advisory Committees;Animals;Area;Arts;base;Bioinformatics;Biological Process;Biological Sciences;Biology;Biometry;Budgets;cell type;Cells;Centers of Research Excellence;college;Communication;Communication Tools;Communities;Complex;Consultations;Data;data exchange;data integration;data repository;Data Science;Data Science Core;design;Development;Disease;Engineering;Ensure;Estrogens;Evaluation;Faculty;Faculty Recruitment;Fostering;Funding;Funding Opportunities;Generations;genomic data;Genomics;Goals;Grant;Health;Home;human subject;Immune;innovation;insight;Internet;Leadership;Macrophage Activation;medical schools;meetings;Mentors;Mentorship;metabolomics;Methods;Molecular;Occupational activity of managing finances;operation;Organism;Persons;Phase;Pilot Projects;Population;Preparation;programs;Proteomics;Protocols documentation;recruit;Regulation;Research;research and development;Research Personnel;Research Project Grants;Resources;Schedule;Schools;Science;Scientist;Secure;single cell genomics;social media;success;System;Systemic Scleroderma;Technology;Training;transcriptomics;United States National Institutes of Health;Visit;Whole Organism;Work

PROJECT_TITLE: Center for Quantitative Biology Administrative Core


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Data Science

PROJECT_TERMS: Address;Advisory Committees;Animals;Area;Arts;base;Bioinformatics;Biological Process;Biological Sciences;Biology;Biometry;Budgets;cell type;Cells;Centers of Research Excellence;college;Communication;Communication Tools;Communities;Complex;Consultations;Data;data exchange;data integration;data repository;Data Science;Data Science Core;design;Development;Disease;Engineering;Ensure;Evaluation;Faculty;Faculty Recruitment;Fostering;Funding;Funding Opportunities;Generations;genomic data;Genomics;Goals;Grant;Health;Home;human subject;Immune;innovation;insight;Internet;Leadership;medical schools;meetings;Mentors;Mentorship;metabolomics;Methods;Molecular;Occupational activity of managing finances;operation;Organism;Persons;Phase;Pilot Projects;Population;Preparation;programs;Proteomics;Protocols documentation;recruit;Regulation;Research;research and development;Research Personnel;Research Project Grants;Resources;Schedule;Schools;Science;Scientist;Secure;single cell genomics;social media;success;System;Technology;Training;transcriptomics;United States National Institutes of Health;Visit;Whole Organism;Work


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Genetics;Human Genome;Pediatric

ORG_CITY: SAN FRANCISCO

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Cleft lip with or without cleft palate (CL/P) represents the most common craniofacial birth defect and is a burden for the individual and society. We will investigate the cell behaviors, genetic pathways, and regulatory networks underlying facial prominence fusion to identify new genes for prenatal diagnostics and tissue repair of CL/P.

PI_NAMEs: SELLERI, LICIA  (contact)

PROGRAM_OFFICER_NAME: SAIFUDEEN, ZUBAIDA

PROJECT_TERMS: Apoptosis;Apoptotic;Bioinformatics;Biological Assay;Bromodeoxyuridine;cdc Genes;cell behavior;Cell Cycle;Cell Cycle Arrest;Cell Cycle Progression;Cell Cycle Regulation;Cell Proliferation;Cells;Cephalic;Cleavage Under Targets and Release Using Nuclease;Cleft lip with or without cleft palate;Cleft Palate;comparison control;Congenital Abnormality;craniofacial;Cryoultramicrotomy;Development;Diagnostic;Effector Cell;Embryo;Epithelial Cells;epithelial to mesenchymal transition;Epithelium;Exhibits;experimental study;Face;Fostering;Frontonasal Prominence;Genes;Genetic;Genetic Transcription;Grant;Histone H3;Human;Image;Immunofluorescence Immunologic;Impairment;In Situ Hybridization;in vivo;Individual;inhibitor;Lip structure;Live Birth;Maxillary Prominence;Mediating;Mesenchyme;Microdissection;Molecular;Molecular Profiling;Morphogenesis;mouse model;Mus;mutant;Neural Crest;orofacial cleft;palate repair;Pathogenesis;Pathway interactions;Population;Pregnancy;Premaxillary palate;prenatal;Process;progenitor;programs;Publishing;Quantitative Reverse Transcriptase PCR;repair strategy;Reporting;Research;single-cell RNA sequencing;Societies;spatiotemporal;Stains;Testing;Time;tissue repair;Tissues;Transcript;transcription factor;transcriptome;Work;wound healing

PROJECT_TITLE: Pbx-Directed Control of Cellular Behaviors that Drive Midface Morphogenesis

STUDY_SECTION: SBDD

STUDY_SECTION_NAME: Skeletal Biology Development and Disease Study Section[SBDD]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Brain Disorders;Conditions Affecting the Embryonic and Fetal Periods;Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Fetal Alcohol Spectrum Disorders (FASD);Genetics;Infant Mortality;Intellectual and Developmental Disabilities (IDD);Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Rare Diseases;Substance Misuse

ORG_CITY: NEW YORK

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Holoprosencephaly (HPE), a common malformation of the forebrain and midface, has a complex etiology involving genetic and environmental risk factors. Fetal alcohol exposure is one such factor, but its interaction with predisposing genetic variants, the identity of its embryonic target cells, and the developmental pathways it affects are all poorly understood. Using mouse models of HPE, we aim to provide insight into these questions to enhance understanding of gene-environment interaction in causation of birth defects.

PI_NAMEs: KRAUSS, ROBERT S. (contact)

PROJECT_TERMS: Acute;Affect;alcohol exposure;Alcohols;Anterior;Apoptosis;Biological Models;Brain;CDON gene;Cell Physiology;Cell Proliferation;Cell surface;cell type;Cells;Cellular Assay;Clinical;Complex;Congenital Abnormality;Craniofacial Abnormalities;Defect;Development;developmental genetics;Embryo;embryo cell;Embryonic Development;Environmental Exposure;Environmental Risk Factor;Epiblast;Erinaceidae;Ethanol;Etiology;Event;experimental study;Failure;fetal;Fetal Alcohol Exposure;gastrulation;gene environment interaction;Gene Expression;Genetic;genetic pedigree;genetic risk factor;genetic variant;Genetic Variation;Heterozygote;Holoprosencephaly;Human;Hydrophobicity;In Situ Hybridization;in vitro Model;insight;malformation;Metabolism;Minor;Modeling;Molecular;Molecular Analysis;morphogens;Morphology;mouse model;Mus;Mutagenesis;Mutation;mutation carrier;Nature;Nodal;Outcome;Pathway interactions;Pattern;Penetrance;Phenotype;Phosphorylation;Population;Primitive Streaks;Prosencephalon;Quantitative Reverse Transcriptase PCR;receptor;response;Risk;SHH gene;Signal Pathway;Signal Transduction;smoothened signaling pathway;stem cells;Structure;synergism;Teratogens;Testing;transcriptomics;Wild Type Mouse

PROJECT_TITLE: Molecular and Developmental Analysis of Holoprosencephaly

STUDY_SECTION_NAME: Development - 1 Study Section[DEV1]


ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: PROJECT NARRATIVE The Johns Hopkins CERSI (JH-CERSI) represents a highly innovative collaboration between the world’s leading regulatory authority and the country’s largest research university. In this renewal, we combine the remarkable success of JH-CERSI since its inception with three new elements to accelerate knowledge and enhance impact in areas of incredibly high regulatory importance. There is not a moment to lose.

PI_NAMEs: ALEXANDER, G. CALEB (contact)

PROGRAM_OFFICER_NAME: BATTLES, JESSICA JOY

PROJECT_TITLE: Johns Hopkins Center of Excellence in Regulatory Science and Innovation


ORG_CITY: BOSTON

ORG_NAME: HARVARD MEDICAL SCHOOL

PI_NAMEs: WALKER, SUZANNE  (contact)

PROGRAM_OFFICER_NAME: HUNTLEY, CLAYTON C

PROJECT_TITLE: Administrative Core


PI_NAMEs: KRUSE, ANDREW  (contact)

PROJECT_TITLE: Project 1: Structure, function, and inhibition of SEDS-family peptidoglycan polymerases


PROJECT_TITLE: Project 2: Targeting Gram-positive Cell Envelope Assembly


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Biotechnology

PHR: Project Narrative. Antibodies and binding proteins have found widespread use in all aspects of life sciences research and are increasingly being used as therapeutics. Here we will develop multiplexed techniques to generate novel antibodies and binding proteins against all target antigens within the human and zebrafish proteomes and quickly screen all of the resulting leads for cross-reactivity. Successful completion of this work will provide a treasure trove of sequence-verified, high-specificity antibodies, and binding proteins.

PI_NAMEs: PLESA, CALIN  (contact)

PROGRAM_OFFICER_NAME: PITTENGER, STEVEN THEODORE

PROJECT_TERMS: Antibodies;antibody libraries;Antibody Specificity;Antigen Targeting;Antigens;Area;Automation;Basic Science;Binding Proteins;Biochemical Process;Biological Assay;Biological Process;Biological Sciences;Bypass;Clinical Research;Complement;cost;cross reactivity;Diversity Library;Gene Library;gene synthesis;Generations;Human;in vivo;Libraries;Measures;Methods;Mutagenesis;Nature;novel;Protein Fragment;Proteome;Proteomics;Reagent;Recombinant Antibody;Reproducibility;Research;Retroelements;Specificity;Techniques;Technology;technology development;Testing;Therapeutic;tool;Work;Zebrafish

PROJECT_TITLE: Proteome Scale Multiplexed Generation of Recombinant Antibodies


NIH_SPENDING_CATS: Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_NAME: SAN FRANCISCO STATE UNIVERSITY

PHR: Cases of and deaths from most chronic diseases are disproportionally higher in communities of color. These health disparities are linked to chronic stress and the proposed research will gather knowledge about anti- racist healing in nature as a tool for stress reduction in BIPOC young adults. The culturally-appropriate, and affirming low-cost interventions that are developed will promote telomere growth to prevent health disparities.

PI_NAMEs: MARQUEZ-MAGANA, LETICIA MARIA (contact);TATE, CHARLOTTE

PROGRAM_OFFICER_NAME: TYSON, FREDERICK L

PROJECT_TERMS: Acceleration;Address;Adult;Age;anti-racism;Behavior;Biological;Biological Markers;Biological Process;Biomedical Research;Black race;Black, Indigenous, People of Color;Cell Aging;Cessation of life;children of color;Chronic Disease;Chronic stress;Cities;Collaborations;Color;Communities;community based participatory research;community engagement;community organizations;Conscious;coping;cost effective;County;culturally appropriate intervention;Data;Development;Discrimination;Disease;disease disparity;disorder risk;Economics;Education;efficacy evaluation;Elements;Employment;Ensure;Environment;Equity;Ethnic Origin;evidence base;experience;Goals;Government;Growth;Guidelines;healing;Health;Health Disparities Research;health disparity;health equity;Health equity research;health inequalities;Housing;Hydrocortisone;improved;innovation;insight;Institutionalization;Intervention;intervention cost;Knowledge;Latinx;Length;Life;Life Cycle Stages;Link;Measurement;member;microaggression;National Institute on Minority Health and Health Disparities;Nature;Outcome;outreach;Pacific Islander;pandemic disease;Participant;peace;Personal Satisfaction;Physical activity;Policies;Population;premature;prevent;preventive intervention;Primary Prevention;Privatization;Process;psychosocial;Public Health;Public Sector;Publishing;Race;racism;Recommendation;Recovery;recruit;Reduce health disparities;Research;Research Personnel;Research Priority;Resources;Risk;San Francisco;screening;Screening procedure;Secondary Prevention;Sister;social health determinants;Specialist;Stress;stress reduction;Students;synergism;System;Teenagers;telomere;Telomere Shortening;Testing;tool;transition to adulthood;Uncertainty;underserved community;United States;uptake;Visit;Walking;Work;young adult;Youth

PROJECT_TITLE: Examining Anti-Racist Healing in Nature to Protect Telomeres of Transitional Age BIPOC for Health Equity.


NIH_SPENDING_CATS: Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Precision Medicine;Prevention;Social Determinants of Health

ORG_DEPT: MISCELLANEOUS

PHR: Project Narrative Massive observational cohorts with the exposome (ie, multiple environmental factors) and phenome (disease risk factors) are being assembled by countries worldwide. We will equip the biomedical community with data science and machine learning tools for robust data-driven imputation, discovery, interpretation, and re-use of complex exposure-phenotype associations that emerge from big data. Applications of our methods will address several high-priority goals for the National Institutes of Environmental Health Sciences (NIEHS) including identification of environmental health disparities in heart disease that are critical for precision medicine implementation.

PI_NAMEs: MANRAI, ARJUN KUMAR;PATEL, CHIRAG J. (contact)

PROGRAM_OFFICER_NAME: DUNCAN, CHRISTOPHER GENTRY

PROJECT_TERMS: Address;All of Us Research Program;analytical method;Big Data;biobank;Biological;Biological Factors;Biological Markers;Cardiology;Catalogs;cohort;Cohort Studies;Communities;Complex;Country;Data;data resource;Data Science;Data Set;deep learning;Demographic Factors;Deposition;Diabetes Mellitus;Diet and Nutrition;Disadvantaged;Disease;disease disparity;disease phenotype;disorder risk;Disparity;Environment;Environmental Exposure;environmental health disparity;Environmental Risk Factor;Epidemiology;Etiology;Exhibits;feature selection;genetic risk factor;Goals;Health;health difference;health disparity;Heart Diseases;Human;hypercholesterolemia;Incidence;Lead;Libraries;Link;Literature;Machine Learning;machine learning method;Malignant Neoplasms;Measurement;Measures;Meta-Analysis;Metadata;Methods;Modeling;National Health and Nutrition Examination Survey;National Institute of Environmental Health Sciences;novel;Observational Study;phenome;Phenotype;Pollution;Population;Population Heterogeneity;precision medicine;Process;Reproducibility;Research Design;Research Personnel;Resources;Risk Factors;Role;Sample Size;Sampling;scale up;Testing;Time;tool;Translations;United States National Institutes of Health;Variant;vibration

PROJECT_TITLE: Data science tools to identify robust exposure-phenotype associations for precision medicine

STUDY_SECTION: BDMA

STUDY_SECTION_NAME: Biodata Management and Analysis Study Section[BDMA]


NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: CHAPEL HILL

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: NARRATIVE This proposal focuses on (i) creation of novel technologies for rigorous and experimentally concise analysis of higher-order RNA structure, (ii) application of these technologies to compelling challenges in understanding how higher-order tertiary structures and regulatory networks govern the functions of pathogenic viruses and coding and non-coding RNAs, and (iii) illumination of principles underlying small-molecule ligandability of RNA. This project will create broadly implementable technologies for analysis of RNA structure and function, and use these to understand biological regulatory networks in novel ways, ultimately driving both basic biological discovery and RNA-targeted drug development.

PI_NAMEs: WEEKS, KEVIN M (contact)

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TERMS: Automobile Driving;Back;Binding;Biological;Biological Models;Biological Process;Cells;Code;Communication;Complex;design;Development;drug development;drug discovery;Elements;Gene Expression Regulation;Genetic Transcription;Goals;Higher Order Chromatin Structure;insight;invention;Knowledge;Lighting;Mediating;Messenger RNA;Methods;Modeling;mRNA Precursor;new technology;novel;Organism;pathogenic virus;RNA;RNA analysis;RNA Conformation;RNA Folding;RNA Splicing;RNA-targeting therapy;small molecule;Structure;Technology;Untranslated RNA;Validation;Work

PROJECT_TITLE: Discovery and Function of Higher-Order RNA Structure

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


ORG_CITY: SALT LAKE CITY

ORG_NAME: VA SALT LAKE CITY HEALTHCARE SYSTEM

ORG_STATE: UT

PHR: The Center for Disease Control and Prevention (CDC) classified Clostridioides difficile infection (CDI) as “Threat level urgent” and called for “urgent and aggressive action” to address a significant public health crisis in 2013 and 2019. The molecular epidemiology of CDI has changed drastically over the past 10 year and the epidemic strain, restriction endonuclease analysis (REA) group BI, PCR ribotype (RT) 027 has decreased significantly. However, REA group Y, which commonly correlates to RT 014 and 020[Y(RT014/020)], has remained a prominent group strain since the 1980s. Despite the endemic nature of Y(RT014/020), a detailed molecular analysis has never been completed. We propose to determine the prevalence and risk factors associated with the endemic Y(RT014/020) and the epidemic BI/RT027 group strains and perform a rigorous genomic analysis of Y(RT014/020) and BI/RT027 obtaining critical information to assess the endemic nature of Y(RT014/020) to assess our hypothesis that Y(RT014/020) resides within an unknown community reservoir.

PI_NAMEs: SKINNER, ANDREW MICHAEL (contact)

PROJECT_TERMS: Accounting;Address;Anaerobic Bacteria;Antibiotics;antimicrobial;bacterial genome sequencing;Centers for Disease Control and Prevention (U.S.);Cephalosporins;Cessation of life;Characteristics;Classification;Clinical;Clostridium difficile;Communities;Data;DNA Restriction Enzymes;Emerging infection;Epidemic;Epidemiologic Factors;Epidemiology;Evolution;Foundations;Genomics;Goals;Healthcare;healthcare-associated infections;Hospitals;Infection;innovation;K-Series Research Career Programs;Laboratories;military veteran;Molecular;Molecular Analysis;Molecular Epidemiology;Morbidity - disease rate;national surveillance;Nature;Pathogenesis;Pathologic;Patients;Phylogenetic Analysis;Polymerase Chain Reaction;Population;Prevalence;programs;protocol development;Public Health;Recording of previous events;Reproduction spores;Resistance;Ribotypes;Risk;Risk Factors;Scientist;Site;Source;stool sample;surveillance data;surveillance study;Surveys;Testing;Time;Training;trend;United States;United States Department of Veterans Affairs;Vertebral column;Veterans;virtual;Virulence Factors

PROJECT_TITLE: Epidemiological and Genomic Characteristics of the Widely Disseminated C. difficile Strain, REA Group Y


NIH_SPENDING_CATS: Clinical Research

PHR: The fellows and mentors trained by this program will contribute to short- and long-term improvements in global health. In collaboration with 21 low- and middle-income country institutions, fellows’ research will help develop clear and effective programs and policies to advance global public health, including care for HIV, other infectious diseases, noncommunicable diseases, global surgery, cancer, mental health and addiction, sexual and reproductive health, and planetary health.

PI_NAMEs: COHEN, CRAIG R (contact);LEE, SUNG-JAE ;MARTIN, NATASHA ;MARTÍNEZ-LÓPEZ, BEATRIZ

PROGRAM_OFFICER_NAME: KATZ, FLORA N

PROJECT_TERMS: burden of illness;California;career;career development;Collaborations;Country;Dentistry;design;Discipline;Discipline of Nursing;Ensure;Environmental Science;Equity;Evaluation;experience;faculty mentor;Faculty Recruitment;Fellowship;Fostering;Funding;global health;Goals;hands on research;Health;improved;Income;innovation;Institution;Instruction;Interdisciplinary Education;Leadership;Los Angeles;Medicine;Mentors;Mentorship;Modeling;online course;Personal Satisfaction;Postdoctoral Fellow;pre-doctoral;programs;Public Health;Race;recruit;Research;Research Methodology;Resources;response;San Francisco;Site;Social Sciences;success;Training;Training and Education;Training Programs;Underrepresented Minority;Universities;veterinary science;Work

PROJECT_TITLE: GloCal - ODSS - M. C.


NIH_SPENDING_CATS: Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Precision Medicine;Racial and Ethnic Minority Health Research

ORG_CITY: WASHINGTON

ORG_NAME: NATIONAL ALLIANCE FOR HISPANIC HEALTH

ORG_STATE: DC

PI_NAMEs: FALCON, ADOLPH P (contact);GIL RICO, EDGAR

PROGRAM_OFFICER_NAME: MARTINEZ, ERICA

PROJECT_TERMS: Address;All of Us Research Program;bilingualism;Communities;community involvement;community organizations;Hispanic Populations;patient engagement;Spanish/English;Touch sensation;Work

PROJECT_TITLE: Healthy Americas: All of Us Research Program


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Patient Safety;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it characterizes key technological barriers to equitable care for patients with Alzheimer’s disease (AD), describing racial/ethnic inequities and rural- urban disparities in access to imaging technologies and to the specialist gatekeepers of these technologies. It identifies how imaging resources should be mobilized to ensure that all patients with AD are able to realize the full benefits of new treatments, and provides guidance to policymakers to support planning and legal and regulatory efforts to mitigate disparities in AD morbidity and mortality.

PI_NAMEs: AGUILA, EMMA ;AILSHIRE, JENNIFER A;ZISSIMOPOULOS, JULIE M (contact)

PROGRAM_OFFICER_NAME: NOVAK, PRISCILLA JOY

PROJECT_TERMS: access disparities;adverse event monitoring;Affect;Alzheimer's Disease;Alzheimer's disease care;Alzheimer's disease diagnosis;Alzheimer's disease patient;Alzheimer's disease related dementia;Alzheimer's disease therapy;American;American Hospital Association;Amyloid;Amyloid beta-Protein;Area;Black race;Brain;Capital;Capital Financing;Characteristics;Community Surveys;cost;critical access hospital;Data;Development;Devices;Diagnosis;Diagnostic;Diagnostic Imaging;Disease;Disease Progression;Disparity;disparity reduction;Edema;Ensure;Equity;ethnic disparity;Ethnic Origin;FDA approved;gaps in access;Gatekeeping;Geographic Distribution;Goals;health care disparity;health equity;Health Technology;Hemorrhage;Hispanic;Hospitals;Image;imaging detection;imaging facilities;Imaging technology;Improve Access;Individual;innovation;Institution;Knowledge;Legal;Magnetic Resonance Imaging;Marketing;Medicare;Medicare claim;Modeling;Morbidity - disease rate;mortality;neuroimaging;new technology;novel therapeutics;Patient Care;Patient Monitoring;Patients;Persons;Pharmaceutical Preparations;Physicians;Policy Maker;Population;Population Heterogeneity;Positron-Emission Tomography;Provider;Public Health;Race;racial disparity;Research;Resources;Rural;rural area;rural disparities;Senile Plaques;Services;Specialist;standard of care;Technology;Training;urban disparity;Urbanicity

PROJECT_TITLE: Disparities in Access to Critical Imaging Technologies for ADRD Diagnosis and Treatment


ADMINISTERING_IC: DP

IC_NAME: NATIONAL CENTER FOR CHRONIC DISEASE PREVENTION AND HEALTH PROMOTION

ORG_CITY: CHARLESTON

ORG_NAME: WEST VIRGINIA STATE HEALTH DEPARTMENT

ORG_STATE: WV

PI_NAMEs: STOVER, MONICA J (contact)

PROJECT_TITLE: DP20-001 Pregnancy Risk Assessment Monitoring System (PRAMS)


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Clinical Research;Data Science;Emerging Infectious Diseases;Health Services;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: COLUMBIA

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

ORG_STATE: SC

PHR: Public Health Relevance Statement NIH has identified “workforce development” as one of its 5 strategic goals for biomedical data science in the coming decades and has called for integrative training in data-science approaches through curricula and mentored research. This proposed R25 program is designed to address the nationwide shortage of Big Data health science researchers in NIAID focus areas. The training program will target junior faculty in health science disciplines at the University of South Carolina and will foster a research environment to encourage individuals from diverse backgrounds, including those from underrepresented groups, to pursue further Big Data health science research in HIV, COVID-19, and other infectious diseases.

PI_NAMEs: LI, XIAOMING  (contact);ZHANG, JIAJIA

PROGRAM_OFFICER_NAME: MOTEN, CARMEN

PROJECT_TERMS: Academic Training;Address;Applications Grants;Area;Artificial Intelligence;Big Data;Big Data to Knowledge;big-data science;biomedical data science;Biometry;Businesses;career;Cessation of life;Clinical;Clinical Medicine;cohort;college;Communicable Diseases;Communities;community engagement;comorbidity;Competence;COVID-19;Data;data acquisition;Data Science;Data Scientist;Data Sources;data streams;design;Development;digital;Discipline;Discipline of Nursing;Disease;Disease Progression;Education Projects;Educational Curriculum;Electronic Health Record;Entrepreneurship;Environment;experience;Face;Faculty;financial incentive;Fostering;Funding;Funding Agency;Generations;genomic data;Genomics;Goals;hands on research;Health;Health Care Research;health data;Health Policy;health science research;Health Sciences;health training;Healthcare;high risk population;HIV;HIV/AIDS;improved;Individual;Industry;Infectious Diseases Research;Information Technology;Infrastructure;innovation;interest;Knowledge;Machine Learning;Manuscripts;Measures;Medicine;Mentors;Methodology;Mission;mobile computing;National Institute of Allergy and Infectious Disease;Outcome;peer;peer coaching;Pharmacy facility;prevent;professor;programs;Public Health;public health intervention;public health relevance;recruit;Research;Research Personnel;Research Project Grants;Research Proposals;Schools;Science;skill acquisition;skills;social media;Social Work;South Carolina;Strategic Planning;synergism;System;Talents;Technology;Time;Training;training data;Training Programs;trend;Underrepresented Populations;United States National Institutes of Health;Universities;Virus;Wages;wearable device;Workforce Development

PROJECT_TITLE: Big Data Health Science Fellow Program in Infectious Disease Research


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Genetics;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: DURHAM

ORG_DEPT: ORTHOPEDICS

ORG_NAME: DUKE UNIVERSITY

PHR: Project Narrative Muscle stem cells are required for muscle maintenance and regeneration, especially under disease and aging conditions. This project aims to explore the function and regulation of a novel subset of muscle stem cells that uniquely interact with the immune system to mediate efficient muscle repair. Knowledge from the proposed work will benefit future studies into treatment of degenerative diseases and age-related muscle wasting.

PI_NAMEs: KUANG, SHIHUAN  (contact)

PROGRAM_OFFICER_NAME: LINDHURST, MARJORIE JEAN

PROJECT_TERMS: Acute;age-related muscle loss;Aging;Anti-Inflammatory Agents;Antigen-Presenting Cells;Bilateral;Biology;Cell Communication;Cell Cycle;Cell Proliferation;cell type;Cells;Coculture Techniques;Coin;cytokine;Data;Degenerative Disorder;Development;Dimensions;Disease;Fluorescence-Activated Cell Sorting;Future;Gene Expression;gene function;Genes;genetic signature;Goals;Growth;Heterogeneity;Immune;Immune response;Immune system;Immunologic Markers;immunoregulation;improved;in vivo;Infiltration;Inflammation;Inflammatory;Inflammatory Response;injured;Injury;injury and repair;Knowledge;Maintenance;Maps;Mediating;Molecular;Muscle;Muscle Cells;muscle degeneration;muscle progenitor cell;muscle regeneration;muscle repair;Muscle satellite cell;Myoblasts;myogenesis;Natural regeneration;novel;novel strategies;Pathologic;Physiological;Population;Population Heterogeneity;postnatal;Proliferating;reconstruction;recruit;regenerative;Regenerative capacity;Regulation;Regulatory Pathway;Reporting;Resolution;response;response to injury;self-renewal;Signal Transduction;single-cell RNA sequencing;Skeletal Muscle;stem cell function;stem cells;Surveys;Testing;tissue stem cells;Work

PROJECT_TITLE: Immunomyoblasts in muscle regeneration


NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROGRAM NARRATIVE This training program is specifically designed to train a new cadre of researchers and leaders to address major but as yet under-studied public health problems engendered by conditions prevalent in urban and rural informal human settlements (slums) of low and middle-income countries (LMIC). This training is relevant also to developed countries as informal settlements in the form of homeless encampments expand. Selected candidates will undergo field training on site in LMICs to develop new global health research skills framedwithin our project research theme of health equity.

PI_NAMEs: BARRY, MICHELE ;HARRIS, EVA ;KO, ALBERT ICKSANG (contact);MADHIVANAN, PURNIMA

PROGRAM_OFFICER_NAME: HAYES, UNJA

PROJECT_TERMS: Address;Africa;Arizona;Asia;California;career;Career Choice;career development;Caribbean region;Central America;Collaborations;Communicable Diseases;Communities;Country;Dedications;design;Discipline;Disease;doctoral student;Eastern Europe;Educational workshop;Environmental Health;Exposure to;Faculty;faculty mentor;global health;Health;health equity;Health equity research;HIV;Human;Inequity;Injury;Institution;Interpersonal Violence;low and middle-income countries;member;Mental Health;Mentors;Mentorship;Methods;multidisciplinary;Persons;Postdoctoral Fellow;pre-doctoral;programs;recruit;Research;Research Methodology;Research Personnel;Research Support;Research Training;Rural;Scholars Program;Site;skills;Slum;South America;Substance abuse problem;Time;Training;Training Programs;Universities;Vulnerable Populations;Women's Health;Work

PROJECT_TITLE: GHES - OBSSR - Kimaru

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(58)-R]


NIH_SPENDING_CATS: Cardiovascular;Climate-Related Exposures and Conditions;Clinical Research;Clinical Trials and Supportive Activities;Prevention;Sleep Research;Social Determinants of Health

ORG_CITY: CLEVELAND

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: NARRATIVE Air pollution is the world’s most important environmental risk factor that contributes more to global morbidity and mortality than tuberculosis, malaria, AIDS, wars and famine combined. In this transformative project, we provide compelling new data on air pollution as a disruptor of endogenous biologic “circadian” rhythms. Through careful studies in animals and humans and large cohorts, we will evaluate the impact of exposure and personalized interventions on heart and metabolic health. Our results will provide compelling new data to prevent the health problems caused by air pollution exposure globally.

PI_NAMEs: RAJAGOPALAN, SANJAY  (contact)

PROGRAM_OFFICER_NAME: NADADUR, SRIKANTH

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Air;Air Pollution;Animals;Biological;Cardiometabolic Disease;cardiometabolic risk;cardiovascular risk factor;Cardiovascular system;circadian;Circadian Dysregulation;Circadian Rhythms;cohort;Data;Disease;Environmental Risk Factor;Epigenetic Process;Famines;genome wide association study;Goals;Health;Health Policy;Heart;Human;Influentials;innovation;Insulin Resistance;Intervention;Intervention Trial;Light;Link;Malaria;Mediating;Mediator;Mendelian randomization;Metabolic;Metabolic dysfunction;Morbidity - disease rate;mortality;National Institute of Environmental Health Sciences;Non-Insulin-Dependent Diabetes Mellitus;Particulate Matter;Pathway interactions;personalized intervention;personalized strategies;prevent;programs;protective effect;Public Health;Research;Risk;Sleep;success;translational clinical trial;translational framework;Translational Research;Tuberculosis;Vulnerable Populations;War

PROJECT_TITLE: (CIRCADIAN) Circadian Disruption as Mediator of Cardiometabolic Risk in Air Pollution


PHR: PROGRAM NARRATIVE This training program is specifically designed to train a new cadre of researchers and leaders to address major but as yet under-studied public health problems engendered by conditions prevalent in urban and rural informal human settlements (slums) of low and middle-income countries (LMIC). This training is relevant also to developed countries as informal settlements in the form of homeless encampments expand. Selected candidates will undergo field training on site in LMICs to develop new global health research skills framed within our project research theme of health equity.

PROJECT_TERMS: Address;Africa;Arizona;Asia;California;career;Career Choice;career development;Caribbean region;Central America;Collaborations;Communicable Diseases;Communities;Country;Dedications;design;Discipline;Disease;doctoral student;Eastern Europe;Educational workshop;Environmental Health;Exposure to;Faculty;faculty mentor;global health;Health;health equity;Health equity research;HIV;Human;Inequity;Injury;Institution;Interpersonal Violence;low and middle-income countries;member;Mental Health;Mentors;Mentorship;Methods;multidisciplinary;Persons;Postdoctoral Fellow;pre-doctoral;programs;recruit;Research;Research Methodology;Research Personnel;Research Support;Research Training;Rural;Scholars Program;Site;skill acquisition;Slum;South America;Substance abuse problem;Supervision;Time;Training;Training Programs;Universities;Vulnerable Populations;Women's Health;Work

PROJECT_TITLE: GHES - ORWH - Sudhakar


NIH_SPENDING_CATS: Behavioral and Social Science;Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Emerging Infectious Diseases;HIV/AIDS;Hepatitis;Hepatitis - B;Immunization;Infectious Diseases;Liver Disease;Pediatric;Prevention;Rare Diseases;Tuberculosis;Vaccine Related

ORG_CITY: CHIANG MAI

ORG_COUNTRY: THAILAND

ORG_FIPS: TH

ORG_NAME: CHIANG MAI UNIVERSITY

PHR: Thailand HIV/AIDS and Infectious Disease Clinical Trials Unit (THAI CTU)  SF 424 (R&R) Other Project Information – Project Narrative The Thailand HIV/AIDS and Infectious Disease Clinical Trials Unit (THAI CTU) is a collaboration between the Chiang Mai University-Research Institute for Health Sciences (CMU-RIHES) in Chiang Mai, Thailand, and the Thai Red Cross AIDS Research Centre (TRC-ARC) in Bangkok, Thailand. The renewed THAI CTU and its four CRSs will participate in developing and conducting clinical trials proposed by the four NIH HIV/AIDS Clinical Trials Networks: HIV/AIDS adult therapeutics; HIV/AIDS maternal, adolescent and pediatric therapeutics; HIV prevention; and HIV vaccines. The collaboration between the NIH HIV/AIDS Clinical Trials Networks and their affiliated CTUs, including the THAI CTU, will lead to development of innovative and effective measures for HIV treatment and prevention, and ultimately to HIV cure and an end to the global HIV epidemic.

PI_NAMEs: RUXRUNGTHAM, KIAT ;SUPPARATPINYO, KHUANCHAI  (contact)

PROGRAM_OFFICER_NAME: JALLAH, ODAV MARDEA

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Adolescent;adolescent men who have sex with men;Adult;AIDS prevention;Anti-Retroviral Agents;antiretroviral therapy;Behavioral Sciences;Biological;Childhood;clinical development;Clinical Research;clinical research site;Clinical Treatment;Clinical Trials;Clinical Trials Network;Clinical Trials Unit;co-infection;Collaborations;Communicable Diseases;comorbidity;Conduct Clinical Trials;Development;diagnostic technologies;Disease remission;Drug resistance in tuberculosis;drug-sensitive;Epidemic;Epidemiology;Evaluation;Health Sciences;Hepatitis B;Hepatitis B Infection;Hepatitis B Virus;Hepatitis C;high-risk adolescents;HIV;HIV vaccine;HIV Vaccine Trials Network;HIV/AIDS;Immunologics;Incidence;Infant;Infrastructure;Injecting drug user;innovation;Intervention;Investigation;Laboratories;Measures;National Institute of Allergy and Infectious Disease;neutralizing antibody;novel;Opiate Addiction;Outcome;Participant;Passive Immunization;Persons;Pharmacy facility;Population;pre-exposure prophylaxis;Pregnancy;Prevention;Principal Investigator;recruit;Red Cross;Research;Research Institute;Research Priority;Sexually Transmitted Diseases;Site;Social Sciences;System;Technology;Thailand;Therapeutic;Therapeutic Clinical Trial;transgender women;treatment center;Tuberculosis;United States National Institutes of Health;Universities;Vaccination;vaccination against tuberculosis;Viral hepatitis;Virus Diseases


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Cancer;Cancer Genomics;Genetics;Human Genome;Physical Injury - Accidents and Adverse Effects;Radiation Oncology

ORG_CITY: WINSTON-SALEM

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative The goal of this proposal is to identify and study relevant patterns of post-irradiation morbidity and mortality in a controlled, well-defined NHP population, by collaborating and sharing data with qualified investigators. Data sharing and administrative oversight are designed to maximize use of the resource. The program will identify patterns of post-irradiation morbidity; identify characteristics of animals with differing radiation-induced disorders; assess late effects of prior mitigator treatment; and refine the cohort to balance age, sex, dose, and mitigator type.

PI_NAMEs: CLINE, J. MARK (contact)

PROGRAM_OFFICER_NAME: DICARLO-COHEN, ANDREA L

PROJECT_TERMS: Acute;Adolescent;Adult;Adverse effects;Age;Animals;Antibiotics;Atrophic;Autopsy;Biological Markers;Blood;Body Fluids;Bone Marrow;Brain;cancer therapy;Cardiac;Cataract;Characteristics;Chronic diarrhea;Chronic Kidney Failure;Clinical;clinical examination;Clinical Pathology;cohort;Collaborations;Communities;comorbidity;Data;Data Set;data sharing;design;Diabetes Mellitus;Disease;Distant;Dose;Epithelium;Equilibrium;exome sequencing;Failure;Female;Fibrosis;Functional disorder;Funding;Gastrointestinal Diseases;Gene Expression;Genes;Genetic;Genetic Markers;Genomics;Goals;Growth;Hematopoietic;Hematopoietic Cell Growth Factors;Hematopoietic Neoplasms;Human;Image;Immune;Immunophenotyping;Impaired cognition;Impairment;improved;Incidence;Inflammatory;inflammatory marker;Institution;interest;Interleukin-6;irradiation;Knowledge;Late Effects;Lesion;Long-Term Effects;Macaca mulatta;Macrophage;Magnetic Resonance Imaging;male;Measurement;Measures;Medical emergency;Mesenchymal Cell Neoplasm;Metabolic;Metabolic Diseases;microbiome;Modeling;Molecular;Molecular Profiling;Morbidity - disease rate;mortality;Myocardial;Neoplasms;Nervous System Disorder;Neurosecretory Systems;Non-Insulin-Dependent Diabetes Mellitus;nonhuman primate;Organ;Outcome;outreach;Pathology;Pathway interactions;Pattern;Phenotype;Phylogenetic Analysis;Population;programs;protective effect;Qualifying;Radiation;radiation adverse effect;radiation effect;Radiation exposure;Radiation Injuries;radiation mitigator;radiation resistance;Recovery;Research Personnel;Resistance;Resources;response;Rodent;Sampling;Sarcoma;sex;Source;Supportive care;Survivors;Systemic disease;Time;Tissues;trait;Transforming Growth Factor beta;ultrasound;United States National Institutes of Health;Validation;Work

PROJECT_TITLE: The Wake Forest Nonhuman Primate Radiation Survivor Cohort


PROJECT_TITLE: GHES - OBSSR - Wild


NIH_SPENDING_CATS: Cystic Fibrosis;Lung;Orphan Drug;Rare Diseases

PHR: PUBLIC HEALTH STATEMENT – OVERALL Failures of the mucus clearance system can produce consequences for the US population in the context of susceptibilities to inhaled infectious agents and environmental toxins. In addition, failure of the mucus clearance system produces a spectrum of muco-obstructive lung diseases, including COPD, asthma, non-CF bronchiectasis, and the rare genetic diseases cystic fibrosis and pulmonary ciliary dyskinesia. There is a great need to elucidate the normal structure and function of mucins to understand their roles in lung health and to develop strategies for the treatment of chronic failures of mucus clearance, i.e., patients with muco-obstructive diseases.

PI_NAMEs: BOUCHER, RICHARD CHARLES (contact);RUBINSTEIN, MICHAEL

PROGRAM_OFFICER_NAME: LACHOWICZ-SCROGGINS, MARRAH ELIZABETH

PROJECT_TERMS: Address;Air;airway surface liquid;aqueous;Asthma;Binding;Biochemical;Biochemistry;Biological;Biology;biophysical properties;Biophysics;Biostatistics Core;Bronchiectasis;Cactaceae;Characteristics;Chronic;Chronic lung disease;Chronic Obstructive Pulmonary Disease;Cilia;Ciliary Motility Disorders;Claw;combat;Communicable Diseases;crosslink;Cystic Fibrosis;Development;dimer;Disease;Distal;DNA;Doctor of Philosophy;effective therapy;Electrons;Electrostatics;Elements;Ensure;Failure;fluid flow;Functional disorder;Gel;Genes;genetic approach;Genetic study;Geometry;Gland;Goals;Health;Host Defense;Human;Hydration status;Hydrophobicity;Image;improved;In Vitro;in vivo;Infectious Agent;Inhalation;Investigation;Knowledge;Left;Length;Lung;Lung Diseases;lung health;Measurement;Membrane;Microscopic;Molecular;Molecular Biology;Morphology;Mucins;Mucolytics;Mucous body substance;mucus clearance;mucus-associated lung diseases;Mus;Nature;neutrophil;novel;novel therapeutics;Obstruction;Outcome;Pathogenesis;Patients;Polymers;Population;Power stroke;Predisposition;Property;Public Health;Pump;Quality Control;rare genetic disorder;Reagent;Recording of previous events;Regulation;Research;Research Personnel;respiratory;Respiratory Disease;Respiratory Mucin;Risk;Role;Series;Skin;Slide;Stretching;Structure;Submucosa;Surface;System;Tandem Repeat Sequences;Testing;Therapeutic;Therapeutic Agents;therapy development;Toxic Environmental Substances;Toxin;transmission process;treatment strategy;viscoelasticity;Water;Work

PROJECT_TITLE: Multi-Scale Investigations of Respiratory Mucus/Mucin Structure and Function in Health and Disease

STUDY_SECTION: HLBP

STUDY_SECTION_NAME: Heart, Lung, and Blood Program Project Study Section[HLBP(MA)]


NIH_SPENDING_CATS: Clinical Research;Diabetes

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: Contact PD/PI: Maahs, David Matthew PROJECT NARRATIVE The prime objective of our National K12 “Diabetes-Docs: Physician-Scientist Career Development Program” (DiabDocs) is to train and foster the development of diverse physician-scientists for productive and impactful diabetes research careers with a specific focus on type 1 diabetes (T1D). Our K12 program is designed to provide: 1) a mentored research experience, 2) research project support, and 3) career development training, including directed attention to diversity, equity and inclusion. We are confident that we will attract the highest caliber of applicants and mentor them toward impactful careers in academic medicine as skilled physician-scientist leaders. Project Narrative Page 9

PI_NAMEs: DIMEGLIO, LINDA A;MAAHS, DAVID MATTHEW (contact)

PROGRAM_OFFICER_NAME: SPAIN, LISA M

PROJECT_TERMS: Adult;Basic Science;bench to bedside;Budgets;Caliber;career;career development;catalyst;Clinical;cohesion;cohort;design;Diabetes Mellitus;directed attention;Education;Educational Curriculum;Effectiveness;Endocrinology;Ensure;equity, diversity, and inclusion;evidence base;experience;Faculty;Funding;Geography;Goals;Health Services Research;Individual;Institution;Insulin-Dependent Diabetes Mellitus;interest;Investigation;Leadership;Medical Students;Medicine;Mentored Clinical Scientist Development Program;mentoring community;Mentors;multidisciplinary;next generation;Pathway interactions;patient oriented;Physicians;Positioning Attribute;Program Development;programs;Recruitment Activity;Research;Research Personnel;Research Support;Resources;Scholars Program;Science;Scientist;skills;Structure;Training;Underrepresented Populations

PROJECT_TITLE: Diabetes-Docs: Physician-Scientist Career Development Program (DiabDocs)