NIH_SPENDING_CATS: Breast Cancer;Cancer;Women's Health Research

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: The clinical relevance of high insulin levels in breast cancer was revealed, paradoxically, by targeting the highly related type I insulin-like growth factor (IGF) receptor. The fetal isoform is expressed at high levels in cancer but expressed at low levels in insulin target normal tissues. This research will create inhibitors of insulin receptor (IR) with selection for the adult and fetal separate IR isoforms, reveal the mechanism of action of the fetal IR in cancer, and develop treatment strategies to combine IR antagonists with other agents targeting the IGF and insulin receptors.

PI_NAMEs: YEE, DOUGLAS  (contact)

PROGRAM_OFFICER_NAME: FU, YALI

PROJECT_TERMS: Adult;antagonist;Biological Models;blood glucose regulation;Breast Cancer Cell;Breast Cancer Model;Breast Cancer therapy;Breast Cancer Treatment;Cancer Biology;Clinical Trials;clinically relevant;Data;Development;Directed Molecular Evolution;driver mutation;Drug Targeting;effective therapy;efficacy evaluation;Endocrine;Engineering;ERBB2 gene;ESR1 gene;Failure;Family;fetal;Growth;Hyperinsulinism;inhibitor;Insulin;Insulin Antagonists;Insulin Receptor;Insulin-Like Growth Factor Receptor;Insulin-Like-Growth Factor I Receptor;Ligands;Malignant Breast Neoplasm;Malignant Neoplasms;malignant phenotype;member;mortality;Normal tissue morphology;Patients;Play;Protein Isoforms;receptor;receptor function;Regulation;Regulatory Pathway;Research;Resistance;Role;Signal Transduction;Signaling Protein;Somatomedins;synthetic protein;System;targeted agent;Testing;Therapeutic;treatment strategy;Type I Insulin;Woman

PROJECT_TITLE: Disrupting insulin receptor function in breast cancer

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 1 Study Section[MCT1]


ADMINISTERING_IC: CA

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Colorectal Cancer;Contraception/Reproduction;Digestive Diseases;Infertility;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: NASHVILLE

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: NARRATIVE Reproductive health concerns are a long-standing unmet care need that face adults ages 18 to 49 years after a colorectal cancer diagnosis. Our study is powered to identify changes in gonadal function caused by colorectal cancer treatments and to investigate psychosocial dimensions of sexual health and fertility-at diagnosis and at multiple subsequent timepoints along the cancer care continuum-using a unique, prospective cohort of reproductive age patients with colorectal cancer. These findings will lead to incorporating reproductive health care in the clinical management of early-onset colorectal cancer, and ultimately improve outcomes for this growing population.

PI_NAMEs: HOLOWATYJ, ANDREANA NATALIE (contact)

PROGRAM_OFFICER_NAME: FILIPSKI, KELLY

PROJECT_TERMS: Accreditation;Address;Adult;Age;Androstenedione;Biological Assay;Biometry;Blood;Blood specimen;cancer care;Cancer Center;cancer diagnosis;cancer epidemiology;Cancer Survivor;Caring;Certification;chemotherapy;child bearing;Clinical;Clinical Management;Clinical Psychology;cohort;Cohort Studies;Collection;colon cancer patients;Colorectal Cancer;colorectal cancer treatment;Continuity of Patient Care;Data;dehydroepiandrosterone;design;Diagnosis;Dimensions;Early Diagnosis;early onset colorectal cancer;Enrollment;Estradiol;Face;Family;Fasting;FDA approved;Female;Fertility;fertility preservation;follow-up;gastrointestinal;Goals;gonad function;Gonadal structure;Growth;Health;Healthcare;Heterogeneity;Hormones;Immunoassay;improved;improved outcome;Incidence;inhibin B;innovation;Institutional Review Boards;instrument;Interview;Laboratories;Life Style;Light;male;Measures;Medical Oncology;men;Modeling;multidisciplinary;Newly Diagnosed;Operative Surgical Procedures;Oral Contraceptives;Outcome;patient population;Patients;Pattern;Physiological;pill;Population;Premenopause;prospective;Prospective cohort;Prospective, cohort study;psychologic;psychosocial;Psychosocial Assessment and Care;Quality of life;Questionnaires;Radiation therapy;Recording of previous events;Reporting;reproductive;Reproductive Endocrinology;Reproductive Health;Reproductive History;Research Design;sample collection;Sample Size;Sampling;satisfaction;sex;Sex Functioning;sexual and reproductive health;Sexual Health;SHBG gene;Social support;sociodemographics;Standardization;study population;Testosterone;Time;treatment planning;Treatment Protocols;Visit;Women's Health

PROJECT_TITLE: Physiological and psychosocial aspects of reproductive health after early-onset colorectal cancer

STUDY_SECTION: ICSC

STUDY_SECTION_NAME: Interdisciplinary Clinical Care in Specialty Care Settings Study Section[ICSC]


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: GAINESVILLE

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE Abdominal aortic aneurysms (AAA) and subsequent aortic rupture can lead to sudden death and are a significant clinical problem with increasing prevalence and no known medical treatment. Our goal with the present proposal is to identify whether the defective clearance of dead cells (efferocytosis) by endothelial cells triggers a signaling cascade leading to thrombus formation, iron-mediated cell death, and pannexin-1 channel activation in the progression of AAAs. Importantly, the clinical translation of the experimental studies will be enhanced, by using our newly described chronic mouse model of aneurysm formation and aortic rupture, as well as analysis of patient AAA samples.

PI_NAMEs: SHARMA, ASHISH KUMAR;UPCHURCH, GILBERT RIVERS (contact)

PROGRAM_OFFICER_NAME: STABLEY, JOHN N

PROJECT_TERMS: Abdominal Aortic Aneurysm;Aging;aging related disease;Aneurysm;Animals;Aorta;Aortic Aneurysm;Aortic Rupture;Aortitis;Apoptosis;Apoptotic;Binding;biobank;Blood Circulation;Cell Death;Cell surface;Cells;Chronic;Chronic Disease;Clinical;clinical translation;Coagulation Process;Collagen;Communication;Cystine;cytokine;Data;Disease Progression;Elastases;Elastin;Elderly;Endothelial Cells;Enzymes;Equilibrium;erastin;experimental study;extracellular;Feedback;Fibrin;Functional disorder;Gelatinase A;Genetic;Glutamate Transporter;Goals;Growth;Human;Immune;Impairment;In Vitro;in vivo;Inflammaging;Inflammation;Inflammatory;inhibitor;innovation;insight;Iron;knock-down;Knockout Mice;Leucocytic infiltrate;Lipid Peroxidation;Lipid Peroxides;Macrophage;Mediating;Mediator;Medical;Methods;Modeling;Molecular;mortality;mouse model;Mus;Nature;neutrophil;novel;Pathogenesis;Pathway interactions;Patients;Phagocytes;Phenotype;Phosphorylation;Physiological;Play;Population;Prevalence;prevent;Prevention;Process;Production;Protein S;receptor;Receptor Protein-Tyrosine Kinases;Regulation;Resistance;Resolution;Role;Sampling;Signal Transduction;Small Interfering RNA;Smooth Muscle Myocytes;Spironolactone;Sudden Death;systemic inflammatory response;Testing;Thinness;Thrombus;Tissues;transcriptomics;Tunica Adventitia;Vascular Endothelial Cell;Vascular remodeling

PROJECT_TITLE: Renewal: Pannexin-1 signaling in abdominal aortic aneurysms

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Networking and Information Technology R&D (NITRD);Patient Safety;Rehabilitation;Rural Health;Social Determinants of Health;Substance Misuse;Telehealth

ORG_CITY: BOSTON

ORG_DEPT: ADMINISTRATION

ORG_NAME: HARVARD MEDICAL SCHOOL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Alcohol use disorder is a major cause of illness, disability, and death, and there are longstanding challenges in barriers to and disparities in care. This study will examine how telehealth is being incorporated into AUD treatment and whether its use is associated with improved patient outcomes and equity.

PI_NAMEs: BUSCH, ALISA B;HUSKAMP, HAIDEN A. (contact)

PROGRAM_OFFICER_NAME: WHITAKER, DAMIYA EVE

PROJECT_TERMS: addiction;Address;Adult;alcohol abuse therapy;Alcohol consumption;alcohol misuse;alcohol use disorder;Alcohols;Ambulatory Care;Behavior Therapy;Cardiovascular Diseases;care providers;Caring;Cessation of life;Characteristics;Cirrhosis;Clinical;clinical care;clinical practice;Communities;comorbidity;Congresses;COVID-19 pandemic;Data;Diffuse;digital;digital tool;digital treatment;Dimensions;disability;Disparity;Disparity population;disparity reduction;drinking;Emergency department visit;Equity;ethnic minority;Ethnic Origin;Evaluation;experience;Explosion;Health;health care disparity;Health Services Accessibility;Improve Access;improved;Individual;Injury;Insurance Carriers;insurance claims;Interview;Knowledge;machine learning method;Malignant Neoplasms;Medicaid;Medicare;men;Mental Depression;Mental Health Services;Methods;Minority;Modality;Morbidity - disease rate;mortality;Outcome;outpatient programs;Outpatients;pandemic disease;Patient-Focused Outcomes;Patients;Pattern;Patterns of Care;Perception;Persons;Pharmaceutical Preparations;Pharmacological Treatment;Policies;Population;Privatization;programs;Provider;Psychotherapy;Quality of Care;Race;racial minority;Recovery;Recovery Support;Regulation;Risk;Role;Rural;rural area;rural residence;rurality;service utilization;Services;Severities;sex;Substance Use Disorder;Suicide;Technology;telehealth;Telephone;Time;tool;trait;Treatment outcome;Underserved Population;urban area;urban disparity;urban residence;Visit;Vulnerable Populations;Woman

PROJECT_TITLE: Telehealth in the Treatment of Alcohol Use Disorders:  Impact on Access, Disparities, and Quality of Care

STUDY_SECTION: AA

STUDY_SECTION_NAME: Clinical, Treatment and Health Services Research Study Section[AA-3]


ADMINISTERING_IC: GM

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: TUCSON

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: PROJECT NARRATIVE Increasing the diversity of PhD scientists will bring unique perspectives to bear on health issues and will result in more rapid scientific advances. The University of Arizona MARC program seeks to enhance the preparedness of underrepresented students in biomedical areas and to increase the number of students who pursue PhD programs, ultimately increasing the diversity of PhD-level scientists.

PI_NAMEs: MIRANDA, KATRINA M. (contact)

PROGRAM_OFFICER_NAME: AKACEM, LAMEESE DANA

PROJECT_TERMS: Advisory Committees;Arizona;Biomedical Research;career;career preparation;CCL7 gene;cohort;college;design;Development;Doctor of Philosophy;Educational workshop;experience;Extramural Activities;falls;Feedback;Financial Support;Funding;graduate school;improved;Institution;interest;Interview;iterative design;matriculation;meetings;Mentors;Minority;minority health disparity;Oral;posters;Process;programs;Research;responsible research conduct;Safety;Scientist;Secure;Series;Students;success;symposium;Teacher Professional Development;Traineeship;Training;Training Programs;undergraduate student;Underrepresented Students;Universities;Writing

PROJECT_TITLE: MARC Biomedical Research and Training Program at the University of Arizona

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - D[TWD-D]


ADMINISTERING_IC: AI

ED_INST_TYPE: OTHER SPECIALIZED SCHOOLS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: Princeton

ORG_DEPT: MISCELLANEOUS

ORG_NAME: PRINCETON UNIVERSITY

ORG_STATE: NJ

PHR: NARRATIVE Human microbiome-derived bioactive molecules play an important role in mediating microbiome functions and host effects, but we have thus far only discovered a small number of these molecules. Here, we propose to systematically characterize the structure and function of three classes of diverse molecules that are widely encoded by the human microbiome but are currently understudied. Our findings will move us closer towards accurate prediction of microbiome function in health and disease, and allow us to identify potential entry points for targeted interventions.

PI_NAMEs: ABOU DONIA, MOHAMED  (contact)

PROGRAM_OFFICER_NAME: RANALLO, RYAN

PROJECT_TERMS: Bacteria;Binding;Biological;Biological Assay;Cells;Chemical Structure;Chemicals;Clostridium difficile;Communities;Complex;Computer Analysis;Data;Diet;Disease;Ecology;Family;Funding Opportunities;Future;Gene Cluster;genome editing;gut microbiome;Health;host-microbe interactions;Human;human data;Human Microbiome;Hybrids;In Vitro;in vivo;Individual;Intervention;Iron;knowledgebase;Mediating;member;metagenomic sequencing;Metagenomics;Metals;Microbe;microbial;microbiome;microbiome components;microbiome research;Molecular;Mus;Nature;oral microbiome;parallelization;pathogen;Pathogenicity;Pathway interactions;Peptides;Physiology;Play;polyketides;Process;Production;Property;Research;Role;Sampling;Siderophores;skin microbiome;small molecule;Structure;success;synthetic biology;Taxonomy;Therapeutic;Therapeutic Intervention;Time;tool;treatment response

PROJECT_TITLE: Systematic characterization of bioactive molecules from the human microbiome

STUDY_SECTION: XNDA

STUDY_SECTION_NAME: Xenobiotic and Nutrient Disposition and Action Study Section[XNDA]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;Infectious Diseases;Prevention;Rare Diseases;Vector-Borne Diseases

ORG_CITY: INDIANAPOLIS

ORG_DEPT: GENETICS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Project Narrative  The proposed research program will examine the genetics of Aedes aegypti, the mosquito vector for a number of human disease-causing pathogens, including Zika, chikungunya, yellow fever, and dengue arboviruses. Dengue is the most widespread and significant arboviral disease in the world. The proposed investigation will promote the elucidation of novel strategies for mosquito control.

PI_NAMEs: SCHEEL, MOLLY DUMAN (contact)

PROGRAM_OFFICER_NAME: COSTERO-SAINT DENIS, ADRIANA

PROJECT_TERMS: Adult;Adult women;Aedes;arboviral disease;Arboviruses;Behavior;Behavioral;Biological Process;Blood;Cessation of life;chikungunya;Chromatin;Culicidae;dark matter;Dengue;Development;disease transmission;disorder control;Evaluation;feeding;Female;Gene Expression;gene function;Gene Silencing;Gene Targeting;Genes;Genetic;genetic manipulation;Genetic Transcription;Genome;Human;human disease;Insect Vectors;Insecta;Insecticide Resistance;interest;Investigation;Larva;life history;male;Mediating;Medical;Methods;Minor Lymphocyte Stimulatory Loci;Morphology;Mosquito Control;neural;new technology;novel;novel strategies;Oral;pathogen;Pesticides;Physiological;Play;Production;programs;Reproduction;Research;Research Personnel;RNA;RNA Interference;RNA interference screen;Role;Saccharomyces cerevisiae;sex;sexual dimorphism;Specificity;sugar;System;Testing;trait;Transcript;Transcriptional Regulation;transmission process;Untranslated RNA;vaccine development;vaccine distribution;Validation;vector;vector control;vector mosquito;Virus;Women's mortality;Yeasts;Yellow Fever;ZIKA

PROJECT_TITLE: The development of biorational pesticides targeting lncRNAs in adult female Aedes aegypti mosquitoes

STUDY_SECTION: TVZ

STUDY_SECTION_NAME: Transmission of Vector-Borne and Zoonotic Diseases Study Section [TVZ]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Cervical Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;HIV/AIDS;Health Services;Infectious Diseases;Machine Learning and Artificial Intelligence;Prevention;Primary Health Care;Sexually Transmitted Infections;Women's Health Research

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: Project Narrative This research will generate evidence to guide the implementation of high-performance HPV-based cervical cancer screening for women living with HIV. This data is essential to improve the health and wellness of women living with HIV across the globe, and particularly for women in low- and middle-income countries by guiding policy at the national, regional and international level.

PI_NAMEs: LUCKETT, REBECCA  (contact)

PROGRAM_OFFICER_NAME: RADAEV, SERGEY

PROJECT_TERMS: acceptability and feasibility;Acetic Acids;Acquired Immunodeficiency Syndrome;Africa South of the Sahara;aged;aging population;Algorithms;Appointment;Artificial Intelligence;automated visual evaluation;Benign;Biological Assay;Biopsy;Botswana;Cancer Etiology;career;Cervical;cervical cancer prevention;Cervical Cancer Screening;Cervical dysplasia;Cervix Uteri;Cessation of life;Clinical Data;clinical research site;Clinical Services;Clinical Trials Design;cohort;Cohort Studies;Collaborations;Colposcopy;comparative efficacy;cost;Country;Data;Data Analytics;Disease;Effectiveness;Evaluation;evidence base;evidence based guidelines;Excision;experience;follow-up;Foundations;Funding;Geography;Goals;Grant;Guidelines;Health;Health Services;High Prevalence;high risk;high standard;Histopathology;HIV;HPV analysis;HPV negative;HPV positive;HPV screening;HPV-High Risk;Human Papillomavirus;implementation science;implementation strategy;implementation study;Improve Access;improved;Income;innovation;International;Israel;Logistics;Longitudinal cohort;low and middle-income countries;Malignant neoplasm of cervix uteri;Medical center;Mentors;Methods;Microscope;Outcome;Participant;Pathology;Performance;performance tests;Policies;Population;Positioning Attribute;Positive Test Result;Predictive Value;Prevalence;Prevention program;prevention service;prospective;Reach, Effectiveness, Adoption, Implementation, and Maintenance;recruit;reproductive;Research;Research Design;Research Personnel;Research Training;Resource-limited setting;Role;screening;screening policy;screening program;screening services;Services;skills;Socioeconomic Status;Statistical Data Interpretation;study population;success;Testing;Time;Training;Triage;United States National Institutes of Health;uptake;Visual;Visualization;Woman;women's prevention;World Health Organization

PROJECT_TITLE: Evaluation of triage strategies and screening intervals in a human papillomavirus based cervical cancer screening program in women living with human immunodeficiency virus in Botswana

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_CITY: ATLANTA

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative Reinfection with seasonal influenza viruses has the potential to occur each year with waning pre- existing immunity and suboptimal vaccine efficacy. The goal of this proposal is to identify immune factors from prior infections and vaccination that correlate with reduced susceptibility to airborne transmission of seasonal influenza viruses in the ferret model. This research will provide a more relevant animal model that better mimics airborne transmission of influenza viruses within the human population and will better inform future universal vaccine strategies.

PI_NAMEs: LAKDAWALA, SEEMA S. (contact)

PROGRAM_OFFICER_NAME: ARNOLD, MICHELLE MARIE

PROJECT_TERMS: Age;Air;Animal Model;animal model development;Animals;Antibodies;Attenuated;Cellular Immunity;cross reactivity;Data;Ensure;Environment;Epidemic;Epidemiology;Evolution;Exposure to;Ferrets;fitness;flu transmission;Future;Goals;Human;Immune;Immune response;Immunity;Immunologic Factors;Immunologics;Immunology;Individual;Infection;Influenza A virus;Influenza A Virus, H1N1 Subtype;Influenza A Virus, H3N2 Subtype;influenza virus strain;influenzavirus;Letters;Longevity;Medicine;Modeling;Mucosal Immune Responses;Nature;neutralizing antibody;new pandemic;novel;pandemic disease;pandemic virus;pathogen;Pathogenesis;Peripheral;Population;Predisposition;pressure;prevent;Public Health;Publishing;Regimen;Research;respiratory virus;Role;seasonal influenza;Seasons;Shapes;success;T-Lymphocyte;Tissues;transmission process;universal vaccine;Vaccinated;Vaccination;vaccine effectiveness;vaccine efficacy;vaccine platform;vaccine strategy;Vaccines;Viral;Viral Proteins;viral transmission;virology;Virus;Virus Diseases;Work

PROJECT_TITLE: Role of preexisting immunity on airborne transmission of influenza viruses

STUDY_SECTION: VMD

STUDY_SECTION_NAME: Vaccines Against Microbial Diseases Study Section[VMD]


ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: The immune system is now known to play a central role, not only in the control of infection and the development of autoimmunity and allergies, but in both control and promotion of cancer, development of cardiovascular disease, appropriate neurological functioning in the brain, and chronic inflammation. the Interdisciplinary Training Program in Immunology at the University of Virginia School of Medicine is constructed to bring together faculty and trainees with diverse interests but a common focus on the immune system’s involvement in these processes, and to support them with access to cutting edge technologies. In so doing, we intend to develop the next generation of outstanding Immunologists who will continue to uncover the fundamental workings of the immune system, and the ways in which these can be harnessed in the service of improving human health.

PI_NAMEs: BROWN, MICHAEL G;MCNAMARA, COLEEN A;SPERLING, ANNE I. (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Immunology;Training Programs

STUDY_SECTION: AITC

STUDY_SECTION_NAME: Allergy, Immunology, and Transplantation Research Committee[AITC]


NIH_SPENDING_CATS: Neurosciences;Nutrition;Obesity

PHR: The studies described in this proposal will functionally characterize two highly conserved inter-organ communication systems that are essential for ensuring proper control of body size and function during an organism’s development and interactions with its surroundings. Identifying and characterizing these mechanisms is central to understanding many fundamental issues that underlie significant human health problems including obesity, endocrine abnormalities, and developmental disorders.

PI_NAMEs: O'CONNOR, MICHAEL BRENDAN (contact)

PROGRAM_OFFICER_NAME: XU, JIANHUA

PROJECT_TITLE: Inter-organ signals regulating body size, physiology anddevelopmental timing

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Genetics;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: PHILADELPHIA

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Our studies will determine the full hematopoietic lineage plasticity of YY1-null pro-B cells, and their developmental pathway of developing alternative lineages. Mechanistic studies will explore the molecular mechanisms of YY1 control of lineage commitment. Defects in these processes can cause hematopoietic and immune defects, and our studies may define a new general mechanism for regulating lineage commitment and development that may be applicable to other systems, and that potentially could be used therapeutically.

PI_NAMEs: ATCHISON, MICHAEL LEE (contact)

PROGRAM_OFFICER_NAME: SINGLETON, KENTNER L

PROJECT_TERMS: B-Lymphocytes;Basophils;Binding;Bone Marrow;CD8-Positive T-Lymphocytes;Cell Lineage;Cells;Chromatin;Chromatin Structure;conditional knockout;Coupled;Data;Defect;Development;developmental plasticity;DNA;DNA Binding;Enabling Factors;eosinophil;Epigenetic Process;Exhibits;experimental study;Gene Expression;Gene Expression Profile;Genes;Genetic Transcription;genomic locus;Hematopoietic;Hematopoietic stem cells;Heterochromatin;Immune;In Vitro;in vivo;Laboratories;Lewis lung carcinoma cell;Lymphoid;Macrophage;Mediating;Molecular;Molecular Genetics;Molecular Profiling;monocyte;Mus;neutrophil;notch protein;Null Lymphocytes;Pathway interactions;Pattern;Peptide Initiation Factors;Phenotype;Process;progenitor;recruit;Regulation;Repression;Role;Signal Transduction;stem cell differentiation;stem cells;Structure;System;T-Lymphocyte;Therapeutic Uses;transcription factor;Transcriptional Regulation;transdifferentiation;YY1 Transcription Factor

PROJECT_TITLE: Mechanisms of lineage plasticity revealed by YY1 deficiency.

STUDY_SECTION: CMIA

STUDY_SECTION_NAME: Cellular and Molecular Immunology - A Study Section[CMIA]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Biotechnology;Genetics;Infectious Diseases;Prevention;Tickborne Diseases;Vector-Borne Diseases

ORG_CITY: RENO

ORG_NAME: UNIVERSITY OF NEVADA RENO

ORG_STATE: NV

PHR: Ticks are obligate hematophagous arthropods and ecto-parasites of every class of vertebrates in almost every region of the world. Despite the increasing information available on ticks, there is lack of molecular tools to understand the basis of tick phenotypes and tick-pathogen interactions. This proposal focus on understanding tick biology on molecular level by developing genome editing tools.

PI_NAMEs: GULIA-NUSS, MONIKA  (contact)

PROJECT_TERMS: Agriculture;Anterior;Arthropod Vectors;Arthropods;Biology;Black-legged Tick;Body Weight;Cattle;Cell Line;Cell Nucleus;Cell Proliferation;Cells;Chimeric Proteins;Complementary RNA;cost;CRISPR/Cas technology;Culicidae;Data;Development;Disease;Disease Vectors;disorder control;DNA;DNA Ligation;DNA Repair;Docking;Double Strand Break Repair;Drosophila genus;Economics;egg;Embryo;Embryonic Development;endonuclease;Event;Excision;experimental study;Exposure to;Frequencies;functional genomics;Future;Gene Expression;gene function;gene-editing approach;Generations;Genes;Genetic;genetic information;Genetic Markers;Genetic Transformation;Genome;genome editing;Genome engineering;Germ;Germ Cells;Germ Lines;Germ-Line Mutation;Goals;Grant;Guide RNA;Heritability;improved;Incidence;Injections;Insecta;interest;Knock-in;Knock-out;knockout gene;Knowledge;Location;Lyme Disease;Mammalian Cell;Mediating;Methods;migration;milk production;model organism;Modification;Molecular;Molecular Biology;Mutation;nano;new therapeutic target;Nonhomologous DNA End Joining;novel strategies;novel vaccines;Nucleotides;Organism;Outcome;pathogen;Pathway interactions;Phenotype;Play;Population;precise genome editing;prevent;promoter;Protocols documentation;Public Health;repaired;Research;RNA interference screen;Scheme;single-cell RNA sequencing;Site;Somatic Cell;Structure of primordial sex cell;System;Techniques;Testing;Tick Control;Tick-Borne Diseases;Ticks;Time;tool;Transgenes;Transgenic Organisms;transmission process;Treatment Cost;United States;vector;Vertebrates;Work

PROJECT_TITLE: Germline Transformation of Ticks


ADMINISTERING_IC: DE

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Dental, Oral, and Craniofacial Disease;Microbiome;Nanotechnology

ORG_DEPT: ENGINEERING (ALL TYPES)

PHR: Project Narrative We have designed small-scale robots using catalytic nanoparticles as building blocks that display automated and tether-free controlled motion with multifunctionality. These robots can locally kill, degrade and retrieve biofilms with high precision and efficacy. This pioneering approach combining nanotechnology and robotics principles will afford an unprecedented level of endodontic biofilm detection and treatment, and will generate the first instance of robotics devices for automated clinical application in the dental field.

PI_NAMEs: KOO, HYUN ;STEAGER, EDWARD  (contact)

PROGRAM_OFFICER_NAME: LOPEZ, ORLANDO

PROJECT_TERMS: 3-Dimensional;3D Print;Anatomy;antimicrobial;Apical;Area;bactericide;Biological;Cell Survival;Clinical;clinical application;Collection;commercialization;Complex;conventional therapy;cost;Coupled;cytotoxicity;Data;Dental;dental biofilm;design;Detection;Development;Devices;Diagnosis;Diagnostic;Disinfection;Drug Delivery Systems;efficacy study;efficacy testing;Electromagnetics;Endodontics;Ensure;Excision;Family suidae;follow-up;Foundations;Future;Geometry;Human;improved;In Situ;in vivo;Infection;iron oxide nanoparticle;Irrigation;Jaw;Licensing;Location;magnetic field;Magnetism;Mammalian Cell;Manuals;Mechanics;Medicine;Methods;Microbial Biofilms;microrobot;Modality;Modeling;Molds;Morphology;Motion;Movement;nanoparticle;Nanotechnology;Needles;new technology;novel strategies;Oral;oral biofilm;Oral cavity;Outcome;particle;Performance;periapical;Peroxidases;Pharmaceutical Preparations;Polymers;polymicrobial biofilm;Pre-Clinical Model;Procedures;Property;prototype;Pulp Canals;response;Retrieval;Robot;robotic device;robotic system;Robotics;Sampling;Shapes;Site;Small Business Innovation Research Grant;soft tissue;stem cells;Structure;System;Technology;Testing;theranostics;Therapeutic;tongue papilla;Tooth structure;treatment optimization;Ultrasonics;Visualization

PROJECT_TITLE: Small Scale Robotics for Automated Dental Biofilm Theranostics

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]


NIH_SPENDING_CATS: Genetics

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: PROJECT NARRATIVE Many cancers and neurodegenerative diseases exhibit aberrant translation of mRNAs and misregulation of trans- lation factors. Our research program will uncover new mechanisms of translational regulation, and identify their relevance to human diseases caused by mutations in genes encoding the translation machinery.

PI_NAMEs: SUBRAMANIAM, ARVIND RASI (contact)

PROGRAM_OFFICER_NAME: REDDY, MICHAEL K

PROJECT_TERMS: Amino Acids;Cells;Codon Nucleotides;Disease;Exhibits;experimental study;Funding;Gene Expression;Gene Expression Regulation;Genes;Goals;human disease;interdisciplinary approach;kinetic model;Macromolecular Complexes;Malignant Neoplasms;Mediating;Messenger RNA;mRNA Decay;mRNA Stability;mRNA Translation;Mutation;Neurodegenerative Disorders;novel;Open Reading Frames;Process;programs;Protein Biosynthesis;protein expression;Regulation;Research;Ribosomes;ribosomopathy;Role;Signal Transduction;Site;translation factor;Translational Regulation;Translations;Untranslated RNA

PROJECT_TITLE: Regulation of Protein Synthesis by Synonymous Codon Usage

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-K(55)R]


NIH_SPENDING_CATS: Cardiovascular;Genetic Testing;Genetics;Heart Disease;Human Genome;Rare Diseases

PHR: NARRATIVE Dilated cardiomyopathy (DCM) is a highly heritable trait that affects up to 1:250 individuals and is responsible for ~40% of cardiac transplants, yet causal variants are identified in fewer than half of patients, ~30-40% of tests return variants of uncertain significance (VUS), and modest number of genes have adequate genotype- phenotype data to inform medical management. Harmonizing data from five large biobanks, we will use sequencing data and innovative approaches we have developed that leverage segments of the genome shared due to recent common ancestry to: 1) define the contribution and clinical effects of known DCM genes, 2) assess the pathogenicity of candidate DCM gene and VUS, and 3) discover novel DCM risk loci. These aims will fill important knowledge gaps in DCM clinical genetics, improve the yield and interpretation of DCM genetic testing, and inform gene-based precision care and screening.

PI_NAMEs: BELOW, JENNIFER ;WELLS, QUINN STANTON (contact)

PROGRAM_OFFICER_NAME: YARDEN, RONIT I

PROJECT_TERMS: Address;Affect;Age;Age of Onset;Alleles;Arrhythmia;barrier to care;biobank;Candidate Disease Gene;candidate identification;Cardiac;Cardiology;Caring;causal variant;Clinic;Clinical;clinical effect;Clinical Management;Clinical Research;clinically significant;cohort;Communities;Data;data harmonization;Data Set;defined contribution;Diagnosis;Dilated Cardiomyopathy;Disease;disease-causing mutation;Distant;DNA;England;Equilibrium;European ancestry;exome sequencing;Future;Genes;Genetic;Genetic Research;genetic testing;Genetic Variation;genome wide association study;Genomic Segment;Genomics;Genotype;Goals;Guidelines;Heart Transplantation;Heritability;Heterogeneity;Human Genetics;identity by descent;improved;Individual;Informatics;innovation;Intervention;Knowledge;Link;Literature;Maps;Medical;Medical Genetics;Methods;novel;Participant;Pathogenicity;Patient Care;Patients;Penetrance;personalized care;personalized screening;phenome;Phenotype;phenotypic data;Population;proband;rare variant;Recommendation;Relative Risks;Reporting;Research;Resources;Risk;risk stratification;risk variant;Sample Size;screening;Site;Testing;trait;Uncertainty;Variant;variant detection;variant of unknown significance;Work

PROJECT_TITLE: Discovery and Characterization of Rare Variant Effects in Dilated Cardiomyopathy via Large-Scale Biobank Analysis

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Dementia;Neurodegenerative;Neurosciences

ORG_DEPT: NEUROSCIENCES

PHR: Project Narrative Both cerebrovascular and microglial dysfunction are common in Alzheimer’s Disease (AD) but microglial interactions with and potential modulation of neurovascular structure and function not been studied. This project will investigate specific roles for microglia, microglial Trem2 receptors and microglial regulation of astrocyte function as a novel mechanism for microglial-vascular interactions and neurovascular function that may be relevant in AD.

PI_NAMEs: EYO, UKPONG BASSEY (contact)

PROGRAM_OFFICER_NAME: YIN, XILING

PROJECT_TERMS: abeta accumulation;Ablation;Aging;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease risk;Amyloid;Amyloid deposition;Astrocytes;Blood;Blood Vessels;Body Weight;Brain;Brain Diseases;brain dysfunction;Brain Injuries;Brain Pathology;Calcium Signaling;cell type;Cells;cerebrovascular;Cerebrovascular Circulation;Cerebrovascular system;Confocal Microscopy;Consumption;CSF1R gene;Data;Development;Diameter;Eating;Functional disorder;genome wide association study;gliovascular;Glucose;Health;Homeostasis;Immune;in vivo two-photon imaging;insight;interest;Macrophage;Mediating;Microglia;Molecular;mouse model;Mus;Mutation;Nerve Degeneration;Neurodegenerative Disorders;neurovascular;neurovascular coupling;novel;Organ;Oxygen;Participant;Pathogenesis;Pathology;Pharmacogenetics;pharmacologic;Physiology;Population;Process;receptor;Regulation;Research;response;risk variant;Role;Signal Transduction;Structure;Testing;tissue fixing;Transgenic Mice;TREM2 gene;two-photon;Vasodilation;Weight

PROJECT_TITLE: Microglial-Neurovascular Dynamics and Regulation of Neurovascular Structure and Function

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Social Determinants of Health;Substance Misuse

ORG_CITY: PROVIDENCE

ORG_NAME: RHODE ISLAND HOSPITAL

ORG_STATE: RI

PHR: PROJECT NARRATIVE  Medications for opioid use disorder (MOUD) are an effective treatment in the community and among incarcerated individuals, yet they are offered in very few correctional settings nationwide. The criminal justice (CJ) system offers a unique opportunity to engage individuals in treatment initiation, given the high prevalence of opioid use disorder (OUD) in jails and prisons and the high risk of opioid overdose upon release. The study will compare treatment outcomes between extended-release buprenorphine (XR-B) to treatment-as-usual sublingual buprenorphine (SL-B) in a CJ setting and conduct a mixed-methods process evaluation which will characterize the facilitators of and barriers to the implementation of this novel treatment modality.

PI_NAMEs: BERK, JUSTIN  (contact)

PROGRAM_OFFICER_NAME: SU, SHELLEY

PROJECT_TERMS: addiction;Address;Adherence;Buprenorphine;career;Caring;Cessation of life;Clinical;Clinical Medicine;Clinical Trials;cohort;Communities;community setting;Correctional Institutions;cost;court;COVID-19 pandemic;Criminal Justice;Data;Data Set;Databases;Dedications;Development;Disparity;Dropout;Drug Screening;effective therapy;Effectiveness;effectiveness clinical trial;Enrollment;Epidemic;Ethics;Evaluation;Event;evidence base;experience;Familiarity;follow-up;Foundations;Funding;Future;General Population;Goals;Grant;health care settings;health management;High Prevalence;high risk;illicit opioid;implementation barriers;implementation evaluation;implementation facilitators;implementation framework;implementation outcomes;implementation science;Imprisonment;Individual;Injectable;Institution;interest;Intervention;Interview;Jail;Life;Link;Literature;marginalized population;Measures;medication for opioid use disorder;Mentors;Methodology;Methods;Modality;Monitor;mortality;novel;opioid mortality;opioid overdose;opioid use;opioid use disorder;Overdose;patient oriented;Patients;Persons;Pharmaceutical Preparations;Pilot Projects;Policies;Population;prevent;primary outcome;Prisons;process evaluation;programs;Public Health;Publishing;racial disparity;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;reincarceration;Research;Research Personnel;Resources;Rhode Island;Risk;Sampling;Scientist;secondary outcome;Site;skills;social stigma;Standardization;Statutes and Laws;Surveys;System;Time;Training;treatment as usual;treatment center;treatment comparison;Treatment outcome;trial comparing;United States National Institutes of Health;uptake;Urine;Vulnerable Populations;Work

PROJECT_TITLE: Injectable Extended-Release Buprenorphine (XR-B) in a Correctional Setting: A Pilot Randomized Controlled Trial

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

ORG_CITY: CAMBRIDGE

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

PHR: PROJECT NARRATIVE Immunotherapies have been revolutionary for treating a variety of cancer types, but still many patients do not respond or become resistant to currently available therapies, highlighting the need for more effective melanoma treatments. Endogenous retroelement re-expression may be a strategy for rendering tumors more immunogenic and therefore more treatable through immunotherapies, but this remains understudied. This proposal will examine the role of factors controlling expression of ERVs in augmenting the anti-tumor immune response, which will improve our understanding of cancer immunology and may identify new targets for therapeutic development.

PI_NAMEs: MCGEARY, MEAGHAN K. (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: Address;Animal Model;anti-melanoma immunity;anti-tumor immune response;Antigen Presentation;Antigens;Breast;Breast Melanoma;Cancer cell line;cancer immunotherapy;Cancer Patient;cancer type;candidate validation;CD8-Positive T-Lymphocytes;cell killing;Cells;chimeric antigen receptor T cells;Clinical;Colorectal;Complex;Coupled;CRISPR screen;Data;Deposition;derepression;Elements;Endogenous Retroviruses;Epigenetic Process;Euthanasia;experience;Gene Expression;Generations;Genetic;Genetic Transcription;Histone Deacetylase Inhibitor;Human;Human Genome;I-antigen;immune activation;immune clearance;Immune response;Immune system;Immune Targeting;immunogenic;immunogenicity;immunomodulatory therapies;Immunotherapeutic agent;Immunotherapy;improved;improved outcome;in vivo;Infection;Interferon Activation;Interferon Type I;Interferons;IRF3 gene;Knock-out;Knowledge;lung cancer cell;Malignant Breast Neoplasm;Malignant Neoplasms;Melanoma;Melanoma Tumor;member;Methylation;Methyltransferase;Mus;neoplastic cell;new therapeutic target;novel;Outcome;Pathway interactions;Patient-Focused Outcomes;Patients;pharmacologic;Phase;Postdoctoral Fellow;Pre-Clinical Model;Prognosis;Proteins;Reaction;Regulation;Renal Cell Carcinoma;Repression;Research;Resistance;response;Retroelements;Role;T-Lymphocyte;targeted treatment;Testing;Therapeutic;therapeutic development;Transcript;transmission process;tumor;Tumor Antigens;tumor growth;Tumor Immunity;tumor immunology;Up-Regulation;Viral;Viral Physiology;whole genome;Work;Xenograft Model

PROJECT_TITLE: Targeting Endogenous Retrovirus Regulation for Augmenting Cancer Immunotherapy


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Lung;Pediatric;Pediatric - AIDS;Rare Diseases;Tuberculosis

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: PROJECT NARRATIVE TB-related morbidity and mortality is high in children, especially among those living with HIV, missed by respiratory sampling. We have developed a rapid and sensitive nanoplasmon-enhanced scattering (nPES) assay which directly detects M. tuberculosis-specific exosomes from as little as 1 L of serum. The proposed study will utilize cryopreserved specimens from children enrolled in well-characterized completed and proposed prospective cohorts with high HIV prevalence and intensive TB investigations to evaluate the performance of nPES Mtb-specific exosome detection for pediatric TB diagnosis and treatment response, including evaluation of a point-of-care prototype, and are poised to evaluate additional sample types including urine in future directions.

PI_NAMEs: LACOURSE, SYLVIA  (contact)

PROGRAM_OFFICER_NAME: LACOURCIERE, KAREN A

PROJECT_TERMS: 5 year old;Adult;aspirate;Bacille Calmette-Guerin vaccination;Bayesian Method;Biological;Biological Assay;Biological Markers;biological specimen archives;biomarker discovery;Blood;Blood specimen;Cell Compartmentation;Cellular Phone;Cessation of life;Child;Childhood;Classification;Clinical;Clinical Data;Clinical Treatment;cohort;Collection;cost;Cryopreservation;Darkness;Detection;Development;Diagnostic;diagnostic tool;Disease;Early identification;Endosomes;Enrollment;Epidemiologic Methods;Equation;Evaluation;exosome;experience;extracellular vesicles;field study;Future;Genetic;Highly Active Antiretroviral Therapy;HIV;Household;Immune response;Immunological Models;improved;Infant;Investigation;Kenya;Link;lipoarabinomannan;Lipoproteins;Macrophage;Malignant Neoplasms;Measures;Methods;Microscopy;Modeling;Molecular;molecular diagnostics;Monitor;Morbidity - disease rate;mortality;mycobacterial;Mycobacterium tuberculosis;Mycobacterium tuberculosis antigens;nanotechnique;novel diagnostics;Participant;Pathogenesis;Patients;Pediatric cohort;pediatric human immunodeficiency virus;Performance;peripheral blood;Play;point of care;Prevalence;prognostic;prospective;Prospective cohort;Proteins;prototype;Rapid diagnostics;Reference Standards;Research Personnel;respiratory;response;Risk;Role;Sampling;Sensitivity and Specificity;Serum;Specimen;Sputum;Stomach;Surrogate Markers;Surveys;Technology;Testing;Time;Treatment Failure;treatment response;Tuberculosis;Tuberculosis diagnosis;tuberculosis treatment;Tuberculosis Vaccines;Uncertainty;Urine;vaccine trial;X Inactivation

PROJECT_TITLE: M. tuberculosis exosome detection for pediatric TB diagnosis

STUDY_SECTION: HCAC

STUDY_SECTION_NAME: HIV Coinfections and HIV Associated Cancers Study Section[HCAC]


ORG_NAME: GEORGIA INSTITUTE OF TECHNOLOGY

PHR: PROJECT NARRATIVE Peripheral nerve injury is a large-scale problem that affects more than one million people per year in the United States. The investigators propose to design, fabricate, and validate a new class of nerve guidance conduits for the surgical repair of large defects in thick nerves by restoring their continuity and functions. The conduits can enhance nerve regeneration through a synergistic effect arising from uniaxially-aligned fibers, nanoscale grooves engraved on the fibers, and programmed supply of neurotrophic factors at a steady concentration.

PI_NAMEs: BOULIS, NICHOLAS M;XIA, YOUNAN  (contact)

PROGRAM_OFFICER_NAME: KUMSA, DOE WONDWOSSEN

PROJECT_TERMS: Acceleration;Affect;Anatomy;Animals;Autologous Transplantation;Axon;Benchmarking;Biochemical;Biochemistry;biocompatible polymer;biodegradable polymer;Biomedical Engineering;Cellular biology;Chick Embryo;Clinic;controlled release;crosslink;Cues;Defect;design;Distal;efficacy evaluation;Encapsulated;Engravings;fabrication;Face;Facial nerve structure;Fatty Acids;fetal;Fiber;Filopodia;Goals;Growth;Growth Cones;Half-Life;healing;Health;improved;in vitro Model;Individual;Injury;injury and repair;innovation;Kinetics;Knowledge;Lesion;loss of function;man;Masks;Mechanics;medical schools;Modeling;Motor;nanoscale;Nanotechnology;Nerve;Nerve Regeneration;nerve repair;nerve stem cell;Neurites;Neurosurgeon;neurosurgery;neurotrophic factor;novel;Operative Surgical Procedures;particle;Performance;Peripheral nerve injury;Peripheral Nerves;Persons;porcine model;Procedures;Process;Productivity;Protocols documentation;Quality of life;Rattus;Recovery of Function;repaired;Research;Research Personnel;Route;sciatic nerve;Scientist;Site;spheroids;Spinal Ganglia;Structure;Surface;Surgical sutures;System;Technology;Testing;Thick;Translating;Tubular formation;United States;Universities;Welding;Work

PROJECT_TITLE: Hierarchically-Structured Conduits with Programmed Release of Neurotrophic Factors for Repairing Large Defects in Thick Nerves

STUDY_SECTION: BNVT

STUDY_SECTION_NAME: Bioengineering of Neuroscience, Vision and Low Vision Technologies Study Section[BNVT]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Attention Deficit Hyperactivity Disorder (ADHD);Autism;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Climate-Related Exposures and Conditions;Clinical Research;Data Science;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: PROJECT NARRATIVE Air pollution (particulate matter < 2.5 um; PM2.5) exposure increases the risk for neurodevelopmental disorders (NDDs), yet the neural mechanisms underlying these associations are largely unknown. This research adopts a transdiagnostic approach to uncover mechanistic links between PM2.5 exposure and behavioral and neuroimaging phenotypes in children with autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD). Findings will help identify critical windows of susceptibility and underlying mechanisms informing prevention and intervention efforts for these and other NDDs.

PI_NAMEs: RECHTMAN, ELZA  (contact)

PROGRAM_OFFICER_NAME: LAWLER, CINDY P

PROJECT_TERMS: Address;Adolescent;Adopted;Air Pollution;Area;Attention;Attention deficit hyperactivity disorder;autism spectrum disorder;autistic children;Behavior;Behavioral;Behavioral Mechanisms;behavioral outcome;behavioral phenotyping;Big Data;biobank;Biometry;Brain;career;career networking;Characteristics;Chemicals;Child;Childhood;Climate;climate change;climate crisis;climate-related exposures;clinical decision-making;comorbidity;Complex;Data;Data Science;Data Set;Development;Diagnosis;Diagnostic;diagnostic strategy;Dimensions;Disease;Eligibility Determination;Environment;environmental chemical;Environmental Exposure;Environmental Impact;Environmental Risk Factor;Epidemiologist;Epidemiology;Exposure to;Faculty;fine particles;follow-up;Foundations;Functional disorder;Future;gene environment interaction;Goals;Grant;Health;Heritability;high dimensionality;Human;image archival system;Individual;interest;Intervention;Label;Lead;Life;Life Style;Link;Literature;Magnetic Resonance Imaging;Measures;member;Mentors;Mentorship;meter;Methods;Modeling;MRI Scans;multimodality;National Institute of Environmental Health Sciences;Nested Case-Control Study;neural;neurobiological mechanism;Neurobiology;neurodevelopment;Neurodevelopmental Disorder;neuroimaging;neuromechanism;Neurosciences;neurotoxic;New York City;novel;Organizational Models;Outcome;Participant;Particulate Matter;Phase;Phenotype;phenotypic data;Population;Populations at Risk;Positioning Attribute;Prediction of Response to Therapy;Predisposition;Pregnancy;prenatal;prenatal exposure;Prevalence;Prevention;Preventive;Process;Recording of previous events;repository;Reproducibility;Research;Research Personnel;Resolution;Resources;Risk;Sampling;Series;Signal Transduction;skill acquisition;skills training;social;Social outcome;spatiotemporal;Strategic Planning;Stress;Structure;Sum;Technical Expertise;temporal measurement;tenure track;Time;Training;Transcend;Writing

PROJECT_TITLE: Air Pollution, Multidimensional Behavior, and Neuroimaging in Children with Neurodevelopmental Disorders


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE The goal of this proposal is to provide a pre-clinical foundation for optimized glucocorticoid therapy among clinically used glucocorticoids and reveal the interplay among cells type in the response to laryngeal injury and glucocorticoid treatment to assist patients with voice-related disability.

PI_NAMEs: BRANSKI, RYAN COMFORT;GARABEDIAN, MICHAEL J. (contact)

PROGRAM_OFFICER_NAME: KOPF, LISA MARIE

PROJECT_TERMS: Affect;American;Anti-Inflammatory Agents;Anxiety;Asthma;Binding;cell type;Cells;ChIP-seq;Chromatin;chromatin immunoprecipitation;chromatin protein;Chronic Obstructive Pulmonary Disease;Cicatrix;Clinical;clinical investigation;Clinical Management;clinically relevant;cofactor;Communication impairment;Data;Dependence;Development;Dexamethasone;disability;Disease;DNA Binding;Dose;Effectiveness;Equilibrium;Event;experience;experimental study;Fibroblasts;Fibrosis;Fostering;Foundations;Gene Expression;Gene Expression Regulation;gene repression;Gene Targeting;Genes;genetic corepressor;Genetic Transcription;genome-wide;Genomics;Glucocorticoid Receptor;Glucocorticoids;Goals;Half-Life;healing;Health Care Costs;Heterogeneity;Histones;Human;iatrogenic injury;Impairment;improved outcome;In Vitro;in vivo;Income;Individual;Inflammation;Inflammatory;Inflammatory Response;Injections;injured;Injury;innovation;insight;Investigation;Laboratories;Laryngeal Diseases;Laryngeal Injury;Larynx;Lesion;Mass Spectrum Analysis;Mediating;Mental Depression;Methylprednisolone;Molecular;Occupational;Otolaryngologist;Outcome;Pathway interactions;Patients;Pharmaceutical Preparations;pharmacologic;Population;pre-clinical;Pre-Clinical Model;preference;Procedures;Property;Proteins;public health priorities;Publishing;Rattus;receptor binding;recruit;regenerative;Reporting;Repression;response;single-cell RNA sequencing;Site;Small Interfering RNA;social;Steroids;Testing;Therapeutic;Transcription Coactivator;transcription factor;Transcriptional Regulation;transcriptome sequencing;treatment optimization;Treatment Protocols;Triamcinolone Acetonide;vocal cord;Voice;Voice Disorders;Work;wound healing

PROJECT_TITLE: Molecular mechanisms underlying optimal glucocorticoid therapy for vocal fold disease

STUDY_SECTION: MFSR

STUDY_SECTION_NAME: Motor Function, Speech and Rehabilitation Study Section[MFSR]


ORG_DEPT: ANATOMY/CELL BIOLOGY

PHR: Project Narrative Defects in the internal organization of cells and the transport mechanisms of their proteins and membranes underlie the pathogenesis of many human diseases including cancer, neurodegeneration (e.g., Alzheimer’s, Parkinson’s, ALS), brain injury and metabolic disorders. This research program aims to advance our knowledge of how transport within cells is spatially controlled by a unique family of proteins called septins. The proposed research will advance basic knowledge of cell biology, which in the long-term will be used to design better treatments that can reverse or slow down disease and/or to regenerate ailing cells and tissues.

PI_NAMEs: SPILIOTIS, ELIAS T (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TERMS: 3-Dimensional;Alzheimer's Disease;Apical;Brain Injuries;Cell Polarity;cell type;Cells;Cellular biology;Defect;design;Destinations;Disease;Docking;dynactin;Dynein ATPase;Epithelium;Family;GTP-Binding Proteins;Guanosine Triphosphate Phosphohydrolases;Homeostasis;human disease;In Vitro;innovation;insight;Kinesin;Knowledge;Laboratories;Lysosomes;Maintenance;Malignant Neoplasms;Membrane;Membrane Protein Traffic;Metabolic;Metabolic Diseases;Microtubules;Morphogenesis;Motility;Motor;Natural regeneration;Nerve Degeneration;Neurons;neurotransmission;novel;Organoids;Outcome;Parkinson Disease;Pathogenesis;Phosphorylation;Phosphotransferases;Physiological;polarized cell;Positioning Attribute;programs;Protein Family;Protein Sortings;Proteins;reconstitution;recruit;regenerative therapy;Regulation;Research;response;Role;Route;scaffold;Signal Transduction;single molecule;Space Perception;Specificity;Structure;superresolution microscopy;Testing;Tissues;tool;trafficking;Transmembrane Transport;Vesicle

PROJECT_TITLE: Spatial control of membrane traffic by septin GTPases

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-Y(55)R]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Dissemination and Implementation Research;Health Services;Networking and Information Technology R&D (NITRD);Pediatric;Social Determinants of Health;Telehealth

ORG_CITY: PITTSBURGH

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative Emerging adults (EAs) with type 1 diabetes (T1D) are a vulnerable population. While diabetes self-management and education (DSMES) is known to offer opportunities to develop self-management skills required to achieve and maintain short- and long-term diabetes outcomes, EAs are reported to have poor clinic attendance and in turn low participation in DSMES services. This proposal aims to test a novel approach to DSMES that incorporates technological and applied learning-driven methods delivered through group telemedicine visits to improve EA engagement in DSMES with the ultimate goal of improving diabetes outcomes.

PI_NAMEs: LIBMAN, INGRID M (contact);SIMINERIO, LINDA M

PROGRAM_OFFICER_NAME: THORNTON, PAMELA L

PROJECT_TERMS: Address;Adolescent;Adult;Affect;age group;Behavior;Behavioral;behavioral outcome;Caring;Clinic;Clinical;clinical practice;cohort;collaborative approach;contextual factors;Continuous Glucose Monitor;Control Groups;coping;COVID-19 pandemic;Data;Decision Making;design;design,build,test;Development;Devices;Diabetes Mellitus;diabetes risk;diabetes self-management;Education;Effectiveness;effectiveness measure;effectiveness/implementation study;emerging adult;emerging adulthood;Ensure;Exhibits;experience;Feasibility Studies;Future;Goals;hands-on learning;high risk;implementation determinants;implementation evaluation;implementation outcomes;implementation strategy;improved;improved outcome;Insulin-Dependent Diabetes Mellitus;interest;Intervention;Interview;Lead;Life;Literature;Methods;Modeling;Monitor;novel;novel strategies;Outcome;Parents;Patient Monitoring;Patient Participation;patient population;Patients;peer support;Persons;pilot test;pilot trial;pragmatic trial;Preparation;primary outcome;Problem Solving;programs;prototype;Provider;psychosocial;psychosocial outcome;Reporting;Research;response;Risk;satisfaction;Self Care;Self Management;Series;Services;skills;Specialist;Techniques;Technology;telehealth;Telemedicine;Testing;therapy design;Time;uptake;user centered design;Visit;Vulnerable Populations;Work;Youth

PROJECT_TITLE: Application of the Telemedicine for Reach, Education, Access, and Treatment delivery model to engage emerging adults in Diabetes Self-Management Education and Support (TREAT-ED)


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cardiovascular;Cerebrovascular;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

ORG_STATE: CA

PHR: PROJECT NARRATIVE There is a seemingly paradoxical relationship between favorable midlife lipid profiles and high risk of Alzheimer's disease and related dementias (ADRD) among Black Americans that has been severely understudied. Lipids play a vital role in neurodegenerative disease, and epidemiologic and metabolomic studies have identified commonly tested lipids (total cholesterol, HDL cholesterol, LDL cholesterol, and triglycerides) as well as sphingolipids (ceramides) as predictors of cognitive aging. Findings from this research will provide important insights into the relationship of lipids with ADRD among Black Americans exploring lifecourse genetic, psychosocial, and cardiometabolic mechanisms.

PI_NAMEs: GEORGE, KRISTEN M (contact)

PROGRAM_OFFICER_NAME: MARTIN, DAMALI

PROJECT_TERMS: Address;Affect;African American population;Age;Aging;Alzheimer disease prevention;Alzheimer's disease related dementia;Alzheimer's disease risk;Apolipoprotein E;apolipoprotein E-4;Award;Biological Markers;Biology;Black American;Black Populations;Black race;Brain;brain health;California;Cardiometabolic Disease;cardiometabolism;Cardiovascular Diseases;cardiovascular disorder epidemiology;cardiovascular disorder risk;Cardiovascular system;Censuses;Ceramides;Cerebrovascular Trauma;Cholesterol;Chronic stress;Cognitive aging;cohort;Cohort Studies;Data;data harmonization;Data Set;Dementia;dementia risk;Diabetes Mellitus;disorder risk;Disparity;Dyslipidemias;Economics;emerging adult;Epidemiology;Equilibrium;ethnic difference;Ethnic Population;experience;Exposure to;Funding;Genetic;genetic risk factor;Health;health disparity;healthy aging;High Density Lipoprotein Cholesterol;High Density Lipoproteins;High Prevalence;high risk;high risk population;Hippocampus;Homeostasis;Hypertension;Impaired cognition;Incidence;Infarction;insight;Insulin Resistance;International;late life;Latino Population;LDL Cholesterol Lipoproteins;Life Cycle Stages;Life Experience;Link;Lipids;Literature;Low-Density Lipoproteins;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Measurement;Measures;Mediating;Mentorship;metabolomics;Methods;middle age;Modeling;Modernization;Nerve Degeneration;Neurodegenerative Disorders;neuroimaging marker;novel;Obesity;older adult;Pathway interactions;Physiological;Play;Positioning Attribute;Process;Psychometrics;psychosocial;Questionnaires;racial difference;racial population;racism;Research;Research Personnel;Risk Factors;Role;Sphingolipids;Stress;Structural Racism;Testing;theories;Time;Training;Triglycerides;United States;United States National Institutes of Health;Universities;vascular contributions;vascular injury;White Matter Hyperintensity;Work

PROJECT_TITLE: The Role of Lipids in Alzheimer's Disease and Related Dementias among Black Americans: Examining Lifecouse Mechanisms

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development For Early Career Investigators Study Section [AGCD-2]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Aging

ORG_CITY: UNIVERSITY PARK

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

PHR: PROJECT NARRATIVE Social and behavioral experiences have large and pervasive effects on health outcomes during midlife and older adulthood. Understanding the biological pathways by which psychosocial determinants operate promises substantial improvements in public health as well as savings in healthcare costs. This training program will prepare a new generation of researchers in aging to integrate research methods and findings that span from basic biological mechanisms to complex social phenomena.

PI_NAMEs: MARTIRE, LYNN M. (contact)

PROGRAM_OFFICER_NAME: TORRES, DELANY

PROJECT_TITLE: Psychosocial Determinants and Biological Pathways to Healthy Aging (Pathways)


NIH_SPENDING_CATS: Aging;Clinical Research;Clinical Trials and Supportive Activities

ORG_CITY: WINSTON-SALEM

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

ORG_STATE: NC

PHR: Narrative Led by Wake Forest since 2005, the Coordinating Center (CC) for the Pepper OAIC Program builds collaborations that produce synergy within the OAIC network and the aging research community. In this cycle, the CC fostered dramatic growth in the number and impact of OAIC collaborative projects. This proposal, led by a cohesive team of highly experienced leaders with complementary skills, will take full advantage of the increased funding provided in the new RFA to further enhance and extend the impact of the OAIC program by executing 4 Specific Aims, each of which were informed by our preliminary data and evaluations process.

PI_NAMEs: KITZMAN, DALANE W (contact)

PROGRAM_OFFICER_NAME: MERCURE, KATHLEEN ELIZABETH

PROJECT_TERMS: Acceleration;Administrative Supplement;Aging;American;apprenticeship;Award;Capsicum;career;career development;Clinical Research;Collaborations;Communication;Communities;Data;Data Analyses;data integration;data sharing;Development;Directories;Educational Curriculum;Evaluation;evidence base;experience;flexibility;Fostering;Funding;Goals;Growth;Health system;Healthcare;Healthcare Systems;implementation science;improved;Individual;innovation;Institution;instrument;Interview;Leadership;medical schools;meetings;member;Multicenter Studies;multidisciplinary;next generation;novel;older adult;Older Population;pandemic disease;Periodicals;Phase;Philosophy;Policies;Process;Productivity;Professional Organizations;programs;Protocols documentation;Publications;Registries;Research;Research Personnel;Resources;Role;skills;social media;Structure;synergism;Testing;Trust;United States National Institutes of Health;web site;webinar;Work;working group

PROJECT_TITLE: Pepper OAIC Coordinating Center


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Pediatric

ORG_CITY: STONY BROOK

ORG_DEPT: PSYCHOLOGY

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

PHR: Project Narrative Because tonic and phasic irritability in childhood and adolescence predict somewhat different mental disorders and poorer functional outcomes across the lifespan, developing measures specifically designed to assess both the tonic and phasic components of irritability is paramount to continued empirical work in understanding, preventing, and treating youth irritability. By developing and validating a multi-informant rating scale for tonic and phasic irritability, the study will advance the goal of generating a reliable and robust assessment tool to predict illness onset and course in youth. Findings from the study will lay the groundwork for optimizing prediction of risk for specific forms of psychopathology, potentially aiding the identification of those most in need of services and indicating which interventions might be most effective and facilitate assessment of more specific treatment targets.

PI_NAMEs: SILVER, JAMILAH  (contact)

PROGRAM_OFFICER_NAME: CORNELL, ASHLEY ROSE

PROJECT_TERMS: 17 year old;6 year old;Adolescence;Adolescent;Adult;Age;Anger;Area;Assessment tool;Attentional deficit;Behavioral Symptoms;biological sex;Child;Child Rearing;Childhood;Clinic;Clinical;cognitive interview;Communities;Data;design;Development;Disease;effective therapy;emotional symptom;Equipment and supply inventories;Ethnic Origin;Etiology;Exhibits;Factor Analysis;follow up assessment;Functional disorder;Functional impairment;functional outcomes;Generalized Anxiety Disorder;Goals;Grain;Hyperactivity;Impairment;informant;instrument;Intervention;Interview;life span;Literature;longitudinal course;longitudinal dataset;Longitudinal Studies;Measurement;Measures;Mental Depression;Mental disorders;Mental Health;Mental Health Services;Methodology;Methods;Modeling;Moods;negative affect;novel;Onset of illness;Outcome;Outpatients;Parents;Participant;Patient Self-Report;Pattern;Phase;Population;Predictive Factor;prevent;Prevention approach;Process;Psychiatry;psychologic;Psychology;Psychometrics;Psychopathology;Race;Reporting;Research;Research Personnel;response;risk prediction;Sampling;School-Age Population;Schools;Services;Severities;sound;Structure;Substance Use Disorder;suicidal;Surveys;Symptoms;Temperament;Testing;text searching;theories;therapy development;treatment response;Validity and Reliability;Work;Youth

PROJECT_TITLE: Toward Validating a Measure of Tonic and Phasic Irritability in Community and Clinical Samples

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F16-L(20)L]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

PHR: Project Narrative Alzheimer's disease (AD) is a devastating, fatal illness that by far is the fastest-increasing cause of death in the US and will affect as many as 1 in 45 Americans by 2047. The overall goal of this proposal is to study the cerebrovascular dysfunction which is a critical component in AD pathogenesis using a multimodal MRI/PET imaging approach. Successful completion of the current imaging study will yield much richer and more specific information about underlying vascular pathology in AD and advance our understanding of AD pathophysiology and evolution.

PI_NAMEs: JAHANIAN, HESAMODDIN  (contact)

PROGRAM_OFFICER_NAME: LUO, YUAN

PROJECT_TERMS: Acceleration;Accounting;Address;Affect;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer’s disease biomarker;American;Amyloid beta-42;Amyloid beta-Protein;Anatomy;arterial spin labeling;Automobile Driving;Award;Blood;Blood flow;blood flow measurement;Blood Vessels;Brain;brain tissue;capillary bed;Carbon Dioxide;Cause of Death;cerebral microvasculature;Cerebrospinal Fluid;Cerebrovascular Circulation;Cerebrovascular Disorders;cerebrovascular health;cerebrovascular reactivity;Cerebrovascular system;Characteristics;Clinical;Cognitive;Deposition;Development;Disease;Disease Marker;effective therapy;Ensure;Environment;Evolution;fluorodeoxyglucose positron emission tomography;follow-up;Functional disorder;Future;Gases;Generations;glucose metabolism;Goals;imaging approach;imaging modality;imaging study;Impaired cognition;indexing;Individual;individualized medicine;Investigation;K-Series Research Career Programs;Knowledge;Link;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Measurement;Measures;Mediating;Mentored Research Scientist Development Award;Mentors;Metabolic;Methods;Modeling;multimodality;Nerve Degeneration;neuroimaging;Neurons;novel;Pathogenesis;Pathologic;Pathology;Pattern;Play;Positron-Emission Tomography;Process;prodromal Alzheimer's disease;prospective;protein biomarkers;Regulation;Reporting;Research;Research Personnel;Resources;response;Role;senior faculty;Severities;Site;skills;Statistical Models;tau aggregation;tau Proteins;tau-1;Tauopathies;Testing;Therapeutic;tool;Tracer;Training;United States National Institutes of Health;Universities;uptake;Vascular Cognitive Impairment;vascular contributions;Vascular Diseases;Vascular System;Vasodilation;Washington;Waste Products;Work

PROJECT_TITLE: Multimodal investigation of tau-related vasculopathy in prodromal Alzheimer's disease

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Behavior and Social Science of Aging Study Section[NIA-S]


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Prevention;Primary Health Care

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: The mean age of ASD detection and treatment referral remains stable at the relatively late age of 4 years, likely because recommended screening practices are based on a parent questionnaire model, which has low sensitivity, and often only about 1/3 of toddlers who fail questionnaire-based screeners are referred for an evaluation by pediatricians. Eye-tracking, which generates biologically-relevant, objective, and quantifiable metrics of social and non-social visual attention patterns, is a technology that holds considerable promise as a tool to dramatically change how screening is implemented. In this proposal we test the efficacy of eye-tracking as a screening tool to detect ASD at 12, 18 & 24 month well-baby check ups as administered by medical staff in pediatric offices as standard of care and compare results to traditional parent-questionnaire screening approaches.

PI_NAMEs: PIERCE, KAREN L (contact)

PROGRAM_OFFICER_NAME: FREED, MICHAEL C

PROJECT_TERMS: 4 year old;Age;Area;Attention;Auditory;autism spectrum disorder;autistic children;Bioinformatics;blind;Brain;Characteristics;Child;Childhood;Classification;Clinical;clinical phenotype;Cognitive;cohort;Data Set;Detection;Development;Diagnosis;Diagnostic;diagnostic accuracy;Diagnostic tests;digital;early screening;efficacy testing;Electronic Health Record;electronic health record system;Ethnic Origin;Evaluation;Family;Funding;gaze;General Population;improved;innovation;interest;Laboratories;Laboratory Study;Language;Licensing;Machine Learning;Measures;Medical;Medical Staff;Modeling;Modified Checklist for Autism in Toddlers;National Institute of Mental Health;novel;novel strategies;Outcome;Parents;Pattern;pediatrician;Performance;prenatal disorder;Psychologist;Questionnaires;Race;racial population;Reporting;sample fixation;satisfaction;screening;screening guidelines;Screening procedure;Screening Result;Severities;sex;social;social attention;social metrics;Socioeconomic Status;Specificity;Speech;standard of care;Standardization;Statistical Models;Step Tests;Symptoms;synergism;Technology;Test Result;Testing;Time;Toddler;tool;United States National Institutes of Health;Visual;Visual attention;visual tracking;Well baby checks

PROJECT_TITLE: Testing the accuracy of eye tracking as a screening tool for ASD in the general population

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


NIH_SPENDING_CATS: Biotechnology;HIV/AIDS;Immunization;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: SAN DIEGO

ORG_NAME: SAN DIEGO BIOMEDICAL RESEARCH INSTITUTE

PHR: PROJECT NARRATIVE Current HIV vaccines lack the ability to trigger Ab precursors to become broadly neutralizing antibodies that could provide protective vaccine immunity. The problem may in part stem from subtle but important differences between current vaccine Envs & authentic Env spikes on replicating virus surfaces: logically, the form of vaccine Env, including its context & carbohydrate shell, should be as close to a perfect match as possible. Another problem is that the prototype broadly neutralizing antibodies generated during natural infection generally make contacts with sugars on HIV, whereas vaccine antibodies generally avoid these sugars, severely limiting their potential for vaccine protection. It may therefore be crucial to find ways to improve the ability of vaccine NAbs to contact glycans. Here, we seek to identify new concepts to increase the breadth of vaccine-induced neutralizing antibody responses.

PI_NAMEs: BINLEY, JAMES M (contact)

PROGRAM_OFFICER_NAME: MALASPINA, ANGELA

PROJECT_TERMS: Address;Adoptive Transfer;Affinity;Animals;Antibody Response;Apical;Binding;Carbohydrates;CH01 precursor;Clinic;Clonal Expansion;Complex;cost;Development;Dose;Epitopes;Event;Exhibits;Frequencies;Future;Genes;Genetic;Glycoside Hydrolases;Growth;Head;Helminths;Heterozygote;HIV;HIV vaccine;HIV-1;Human;Immunity;Immunization;immunogenic;Immunoglobulin G;Immunoglobulin Somatic Hypermutation;improved;Inbred BALB C Mice;Infection;Keyhole Limpet Hemocyanin;Kinetics;Knock-in;Knock-in Mouse;Measures;Membrane;Memory B-Lymphocyte;Methods;Modeling;Modification;Molecular Genetics;Monitor;Mus;Mutation;neutralizing antibody;neutralizing vaccine;Oryctolagus cuniculus;Peptides;Physiological;Polysaccharides;Pre-Clinical Model;progenitor;Proteins;prototype;Regimen;response;Rest;Schistosomiasis;Selection Criteria;Serum;Shapes;Site;Specificity;stem;Structure;sugar;Surface;Tail;Testing;Time;Vaccinated;Vaccination;vaccine efficacy;vaccine strategy;vaccine-induced antibodies;Vaccinee;Vaccines;Variant;Virus Replication;Virus-like particle;Work

PROJECT_TITLE: Inducing HIV-1 NAb Breadth by Native Trimer Prime-Boost Vaccination

STUDY_SECTION: HIVD

STUDY_SECTION_NAME: HIV Immunopathogenesis and Vaccine Development Study Section[HIVD]


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Palliative Care;Rural Health;Sleep Research;Social Determinants of Health;Telehealth

ORG_CITY: TAMPA

ORG_NAME: UNIVERSITY OF SOUTH FLORIDA

PHR: PROJECT NARRATIVE This trial uses internet technology and community methods to test the acceptability, feasibility and efficacy of NiteCAPP, a brief web CBT-I for rural dementia caregivers (CGs). It offers new understanding of how NiteCAPP improves CG sleep, arousal and inflammation and prompts downstream effects on other outcomes (health, mood, burden, cognition). Demonstration that rural CGs can use NiteCAPP to target sleep, arousal, inflammation and related concerns has important implications for rural CGs/PWDs, their families, clinicians and policymakers.

PI_NAMEs: MCCRAE, CHRISTINA S (contact)

PROGRAM_OFFICER_NAME: MACKIEWICZ, MIROSLAW

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;Adrenal Glands;Adult;Advocate;Aftercare;Alzheimer's Disease;Alzheimer's disease related dementia;Amyloid beta-Protein;Anxiety;Area;arm;Arousal;behavior change;Behavior Therapy;Behavioral;Biological Markers;C-reactive protein;Caregivers;caregiving;Catchment Area;Central Nervous System;Chronic Insomnia;Cognition;Cognitive;cognitive performance;Cognitive Therapy;Communities;community advisory board;County;current pandemic;Dementia;dementia care;Dementia caregivers;Development;Education;Ensure;experience;Face;Family;flexibility;Future;Geography;Goals;Health;Health Occupations;Hypothalamic structure;Immune;Impaired cognition;improved;improved outcome;improvement on sleep;Inflammation;interest;Interleukin-6;Internet;Intervention;lifestyle factors;Low income;Mediator;Medical Research;Medicine;Mental Depression;Methods;Modeling;Moods;multi-site trial;Neurodegenerative Disorders;novel;older adult;Online Systems;Outcome;Patient Self-Report;peer;Peripheral;Personal Satisfaction;Persons;Pituitary Gland;Policy Maker;Population;primary caregiver;primary outcome;Problem Solving;Process;programs;Protocols documentation;Provider;Public Health;Questionnaires;Recommendation;remote technology;Research;Research Priority;Risk;Rural;rural area;rural families;Rural Population;satisfaction;Schedule;Science;secondary outcome;Severities;Sleep;sleep health;sleep onset;Sleeplessness;Stress;stress management;Surveys;tau Proteins;Techniques;Technology;telehealth;Test Result;Testing;theories;therapy development;Time;Training;Translations;treatment optimization;underserved area;United States National Institutes of Health;Validation;Work

PROJECT_TITLE: Web-based CBT for Insomnia in Rural Dementia Caregivers: Examination of Sleep, Arousal, Mood, Cognitive, and Immune Outcomes


NIH_SPENDING_CATS: Biotechnology

ORG_CITY: LOGAN

ORG_DEPT: CHEMISTRY

ORG_NAME: UTAH STATE UNIVERSITY

ORG_STATE: UT

PHR: PROJECT NARRATIVE Many different immune systems have been repurposed as valuable tools in science and medicine (e.g. antibodies and CRISPR). However, the mechanisms of many genetically diverse immune systems remain unknown, suggesting other valuable molecular tools may still be waiting to be discovered. This work aims to understand the structure and function of two different bacterial immune systems that have not yet been characterized, with the hope of identifying novel molecular tools for science and medicine.

PI_NAMEs: JACKSON, RYAN NEAL (contact)

PROGRAM_OFFICER_NAME: CZAPLINSKI, KEVIN

PROJECT_TERMS: Adaptive Immune System;Antibodies;Basic Science;Biochemical;Biological Assay;Biological Sciences;biological systems;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Cryoelectron Microscopy;Development;Diagnosis;Disease;disease diagnostic;DNA Sequence;gene therapy;Genes;Genetic;genome editing;Immune system;immune system function;In Vitro;Knowledge;Medicine;Methods;Molecular;novel;restriction enzyme;Science;Structure;System;Tertiary Protein Structure;tool;Work;X-Ray Crystallography

PROJECT_TITLE: Determining the Structure and Function of Newly Discovered Immune Systems

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-D(55)R]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Emerging Infectious Diseases;Genetics;HIV/AIDS;Immunization;Infectious Diseases;Lung;Orphan Drug;Prevention;Rare Diseases;Tuberculosis;Tuberculosis Vaccine;Vaccine Related

ORG_CITY: ITHACA

ORG_NAME: CORNELL UNIVERSITY

PHR: Project Narrative We lack an effective vaccine against tuberculosis and have an incomplete understanding of those immune pathways by which humans mediate natural control over TB progression. Recently we utilized fluorescent fitness reporter strains of Mtb to demonstrate that restriction of Mtb growth in the mouse lung was linked, both functionally and differentially, to host macrophage lineage and metabolism. We propose building on these foundations to identify immune-mediated pathways of Mtb control that are active or impaired in cells recovered by bronchoalveolar lavage from HIV-1 uninfected and infected human donors in Blantyre, Malawi.

PI_NAMEs: MWANDUMBA, HENRY CHARLES;RUSSELL, DAVID G (contact)

PROGRAM_OFFICER_NAME: MAHON III, ROBERT N

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;active control;Address;Africa South of the Sahara;Alveolar Macrophages;antimicrobial;Bacillus;bacterial fitness;Bronchoalveolar Lavage;Candidate Disease Gene;candidate validation;Cause of Death;Cell Culture Techniques;Cell Lineage;Cell Separation;Cells;Clinical Research;cohort;Collaborations;comorbidity;Data;design;Development;Disease Progression;disorder control;efficacy evaluation;Environment;Equilibrium;experimental study;fatty acid oxidation;fetal stem cell;fitness;Fluorescent in Situ Hybridization;Foundations;Future;gain of function;Genetic Transcription;global health;Glycolysis;Granuloma;Growth;HIV;HIV Genome;HIV-1;Human;human subject;Immune;immune function;Immunity;Immunize;Immunological Models;Immunomodulators;Impairment;In Vitro;in vivo;Individual;Infection;inhibitor;interstitial;Knowledge;Label;Link;loss of function;Lower Respiratory Tract Infection;Lung;Lymphocyte;Lymphoid Cell;Macrophage;Maintenance;Malawi;Mass Spectrum Analysis;Mediating;Mediator;Messenger RNA;Metabolic;Metabolism;Modality;model building;Modeling;Molecular;Mus;Mycobacterium tuberculosis;Myeloid Cells;Nature;novel;Nutritional Immunity;Participant;pathogen;Pathway interactions;permissiveness;Persons;Phenotype;Physiologic pulse;Population;Program Development;programs;Protein Secretion;Proteins;Proteomics;Protocols documentation;recruit;Reporter;Role;Sampling;single-cell RNA sequencing;Small Interfering RNA;small molecule inhibitor;Sorting;therapy design;Tissues;Transcript;transcriptome;transcriptome sequencing;Tuberculosis;Tuberculosis Vaccines;Universities;vaccine development;viral detection;volunteer

PROJECT_TITLE: Lung immune function in human TB infection and its perturbation by HIV-1.


ORG_CITY: BALTIMORE

ORG_DEPT: PHYSIOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Public Health Relevance In both humans and animal models, young females have lower blood pressure than young males; however, as females age their blood pressure increases. We have identified a mouse model (Olfr558 knockout) in which female mice do not increase blood pressure as they age. In these studies, we will work to uncover how Olfr558 modulates blood pressure in aging and menopause.

PI_NAMEs: PLUZNICK, JENNIFER L (contact)

PROGRAM_OFFICER_NAME: GAO, HONGWEI

PROJECT_TERMS: 4-vinylcyclohexene diepoxide;Acetates;Address;Age;aged;Aging;Animal Model;arteriole;Binding;Biological Assay;Blood Pressure;blood pressure elevation;blood pressure reduction;blood pressure regulation;Blood Vessels;Butyrates;Carbon;Cardiovascular Physiology;Cardiovascular system;Cell Physiology;cell type;Cells;Chemicals;Chemoreceptors;Data;falls;Female;G-Protein-Coupled Receptors;Gene Family;Genome;gut microbes;gut microbiota;Human;human model;Hypertension;In Vitro;Individual;insight;Juxtaglomerular Apparatus;Kidney;Knock-out;knockout animal;Knockout Mice;Ligands;male;Measures;Mediating;Mediator;men;Menopause;Midlife women;Modeling;mouse model;Mus;normotensive;Nose;novel;old mice;olfactory receptor;Organ;Orthologous Gene;Pathway interactions;Peripheral;Phenotype;Physiological;placental mammal;Play;Postmenopause;Premenopause;Propionates;public health relevance;Regulatory Pathway;Renin;Reporting;reproductive function;Role;Sampling;Sex Differences;Signal Transduction;Smooth Muscle Myocytes;Telemetry;Testing;Time;Tissues;Translations;Vascular Smooth Muscle;Volatile Fatty Acids;Wild Type Mouse;Woman;women's treatment;Work

PROJECT_TITLE: Olfactory Receptor 558 (Olfr558) and Blood Pressure Regulation in Aging

STUDY_SECTION: IVPP

STUDY_SECTION_NAME: Integrative Vascular Physiology and Pathology Study Section[IVPP]


NIH_SPENDING_CATS: Hematology;Immunotherapy;Infant Mortality;Infectious Diseases;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Sepsis

ORG_CITY: MORGANTOWN

ORG_NAME: WEST VIRGINIA UNIVERSITY

ORG_STATE: WV

PHR: PROJECT NARRATIVE Neonates exhibit increased susceptibility to microbial infections that include bacterial sepsis. This is consistent with a unique immune profile relative to adults. The research described in this proposal will make important advances toward identification of immunological mechanisms that shape the immune response early in life and contribute to susceptibility to infection.

PI_NAMEs: ROBINSON, CORY MICHAEL (contact)

PROGRAM_OFFICER_NAME: MINNICOZZI, MICHAEL

PROJECT_TERMS: Address;Adult;Annual Reports;antagonist;Anti-Inflammatory Agents;Antibiotic Resistance;Antibiotics;Antibodies;antibody conjugate;Bacteremia;Bacteria;Bacterial Infections;Biological Assay;burden of illness;cell type;Cells;Cessation of life;Child;combat;Communicable Diseases;Coupled;cytokine;Data;Disease;early detection biomarkers;early onset sepsis;Escherichia coli;Exhibits;Frequencies;Goals;Growth;high risk;Human;imaging approach;Immune;Immune response;Immune system;Immune Targeting;Immunity;immunological intervention;Immunologics;Immunotherapeutic agent;Impairment;improved;In Vitro;in vivo;Infant;Infant Mortality;Infection;Inflammation;Inflammatory Response;Interleukins;Knockout Mice;Knowledge;Laboratories;Life;Low Birth Weight Infant;Lung;Macrophage;Measures;Mediating;microbial;Modeling;Molecular;monocyte;Morbidity - disease rate;mortality;mortality risk;mouse model;Mus;neonatal mice;neonatal period;neonatal sepsis;neonate;neutralizing antibody;neutrophil;Newborn Infant;Outcome;pathogenic bacteria;Pathology;Pathway interactions;Penetration;Peripheral;Phagocytes;Phenotype;Population;potential biomarker;pre-clinical;Predisposition;Production;promoter;prophylactic;Proteins;Publishing;pup;receptor binding;Reporter;Research;Risk;Risk Factors;Sepsis;Serum;Shapes;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Site;Sorting;Source;Stat3 protein;Stat3 Signaling Pathway;Supportive care;targeted treatment;Therapeutic Intervention;Time;Tissues;trafficking;Transcript;Transgenic Mice;Translating;Validation;Visualization;Vulnerable Populations;Weight Gain;whole animal imaging;Work

PROJECT_TITLE: Understanding IL-27 as a negative regulator of protective immunity during neonatal sepsis

STUDY_SECTION: IHD

STUDY_SECTION_NAME: Immunity and Host Defense Study Section[IHD]


NIH_SPENDING_CATS: Bioengineering;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: FAIRFAX

ORG_NAME: GEORGE MASON UNIVERSITY

PHR: Generation and Description of Neuronal Morphology & Connectivity Brain connectivity and the intricate tree-like shape of individual nerve cells underlie cognitive and physiological functions, and are dramatically altered in almost all known neurological disorders. Using state-of-the-art information technology, data mining, and computational modeling, this project will synthesize, analyze, and freely share a massive amount of quantitative information on neuronal morphology and on the synaptic properties of an exemplary neural system responsible for spatial representation and autobiographic memories. These developments will enable the creation of detailed, biologically plausible, full-scale, quantitatively predictive neural network models to investigate the circuit dynamics of learning and related impairments for the long-lasting benefit of scientific advancement and public health.

PI_NAMEs: ASCOLI, GIORGIO A (contact)

PROGRAM_OFFICER_NAME: OSBORNE, LESLIE CAROL

PROJECT_TERMS: 3-Dimensional;Acceleration;Address;Adult;Affect;Algorithms;Alzheimer's Disease;Animals;Architecture;Autobiography;Axon;base;Biophysics;Brain;Brain region;Cataloging;cell type;Classification;Cognitive;Communities;community collaboration;Complex;Computer Models;Computer software;crowdsourcing;Data;data mining;Data Set;data-driven model;Databases;Date of birth;Deposition;design;Development;digital;digital repositories;Dimensions;Disabling;Drosophila genus;Electronics;entorhinal cortex;Epilepsy;Episodic memory;Flowers;Fostering;Functional disorder;Funding;Generations;Genetic;Goals;Grant;Graph;Growth;Hippocampal Formation;Hippocampus;Human;Image;Impaired cognition;Impairment;Individual;informatics tool;Information Technology;Infrastructure;innovation;Kinetics;knowledge base;Label;Learning;Learning Disabilities;light microscopy;Link;Literature;Measures;meetings;membrane model;Memory;Memory impairment;Methods;model organism;Modeling;Modernization;Molecular;Morphology;multidisciplinary;Nervous System Disorder;neural;Neural Network Simulation;Neuroanatomy;neuroinformatics;neuromechanism;neuronal circuitry;Neurons;Neurosciences;Neurosciences Research;Neurotransmitters;novel;open source;Pathologic;peer;Peer Review;Phenotype;Physiological;Physiology;Play;postsynaptic neurons;Preparation;presynaptic neurons;Probability;Productivity;programs;Property;Public Health;Publications;Publishing;reconstruction;Regional Anatomy;Reporting;repository;Research;Research Personnel;Resource Sharing;Resources;Retrieval;Rodent;Role;Running;Scientific Advances and Accomplishments;Scientist;Shapes;Signal Transduction;simulation;Structure-Activity Relationship;Suggestion;Summary Reports;Synapses;System;Techniques;technological innovation;Testing;Training;transmission process;Trees;usability;Visualization;web portal

PROJECT_TITLE: Generation and Description of Neuronal Morphology and Connectivity

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


NIH_SPENDING_CATS: Digestive Diseases;Liver Disease

ORG_CITY: BETHESDA

ORG_NAME: AMERICAN GASTROENTEROLOGICAL ASSN/INST

PHR: PROJECT NARRATIVE The Fostering Opportunities Resulting in Workforce and Research Diversity (FORWARD) Program is a key part of the American Gastroenterological Association's organizational commitment to expand the pool of physicians and scientists from underrepresented backgrounds and reduce disparities in digestive disease. The next phase of the program aims to retain a diverse research workforce in gastroenterology by preparing and aiding the transition of early-career individuals from underrepresented backgrounds to assume leadership positions within the professional association and in academic medicine. We will build on the successes of our initial five years through a comprehensive curriculum covering essential research skills such as manuscript writing and grant writing (with an emphasis on preparation of an NIH K or R01 grant application); leadership skills aimed at preparing and transitioning participants to roles within AGA committees and academic leadership; and intensive mentorship through a team-based approach.

PI_NAMEs: CRYER, BYRON  (contact);QUEZADA, SANDRA

PROGRAM_OFFICER_NAME: SERRANO, KATRINA JANE

PROJECT_TERMS: Academic skills;Address;African American;Alaska Native;American;American Indians;Applications Grants;Award;Biomedical Research;career;cohort;curriculum development;design;Digestive System Disorders;disparity reduction;Doctor of Philosophy;Educational Curriculum;Educational workshop;experience;Faculty;Focus Groups;Fostering;Funding;Future;Gastroenterologist;Gastroenterology;Goals;Grant;Hepatology;Hispanic;Home;Human Resources;improved;Individual;Institution;K-Series Research Career Programs;Latinx;Leadership;leadership development;Liver diseases;Manuscripts;Medical;Medical Students;Medicine;Mentors;Mentorship;mobile application;National Institute of Diabetes and Digestive and Kidney Diseases;Native Hawaiian;Needs Assessment;Participant;Pathway interactions;peer coaching;Phase;Physicians;Population;Positioning Attribute;Preparation;Principal Investigator;Professional Organizations;Program Development;programs;recruit;Research;research and development;Research Personnel;Research Project Grants;Resources;Role;Scientist;skill acquisition;skills;Societies;Specialist;Structure;success;Surveys;Technology;Training;undergraduate student;Underrepresented Populations;United States National Institutes of Health;Vocational Guidance;Woman;Work;working group;Writing

PROJECT_TITLE: AGA FORWARD PROGRAM - Fostering Opportunities Resulting in Workforce and Research Diversity


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Genetics;HIV/AIDS;Immunization;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: RONDEBOSCH

ORG_COUNTRY: SOUTH AFRICA

ORG_FIPS: SF

ORG_NAME: UNIVERSITY OF CAPE TOWN

PHR: Narrative: Despite the discovery of new prevention tools, and the expansion of treatment, HIV-1 continues to spread. With no effective HIV-1 vaccine available, the passive administration of broadly neutralizing antibodies (bNAbs) for prevention is a promising alternative. This project aims to utilize samples from the first proof-of- concept antibody-mediated prevention (AMP) study in Africa to gain a deeper understanding of how HIV-1 diversity might affect prevention efficacy and to determine the clinical consequences of infection with bNAb resistant viruses.

PI_NAMEs: GILBERT, PETER B.;WILLIAMSON, CAROLYN  (contact)

PROGRAM_OFFICER_NAME: PALIN, AMY COLLEEN

PROJECT_TERMS: Active Immunization;Address;Affect;Africa;Africa South of the Sahara;African;AIDS prevention;Amino Acids;Ancillary Study;Antibodies;arm;Attenuated;Binding Sites;Biological Assay;breakthrough infection;case control;CD4 Lymphocyte Count;Chimera organism;Clinical;Clinical Markers;Clinical Trials;Collaborations;Communicable Diseases;Complex;Consensus;cost;Data;Data Coordinating Center;Effectiveness;env Gene Products;Epidemic;Event;Failure;fitness;flexibility;Fred Hutchinson Cancer Research Center;Future;Genetic Determinism;genetic predictors;Genetic Predisposition to Disease;genetic resistance;Genetic Variation;Genotype;Goals;HIV;HIV Infections;HIV Vaccine Trials Network;HIV-1;HIV-1 vaccine;Immune Evasion;Immunization;improved;in silico;Infection;Infection prevention;infection rate;Infusion procedures;insight;Institution;Investigation;Kinetics;Laboratories;Measures;Mediating;member;mutant;Mutation;Natural Resistance;neutralizing antibody;next generation;novel;Outcome;Parents;Passive Immunization;Pathogenesis;Peripheral Blood Mononuclear Cell;Phase;Phenotype;Predisposition;pressure;Prevention;Prevention approach;Prevention trial;Preventive;programs;Protocols documentation;Research Personnel;Resistance;Safety;Sampling;Science;secondary analysis;Seminal;Serum;Site;South Africa;South African;Standardization;Testing;tool;Training;trait;transmission process;Underrepresented Populations;Universities;Update;vaccine access;Vaccines;Validation;Viral;viral fitness;Viral Load result;viral transmission;Virus;virus genetics;Woman

PROJECT_TITLE: Antigenic and virological traits of HIV-1 breakthrough infections in the VRC01 antibody-mediated prevention Phase 2b trial in sub-Saharan Africa


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Genetic Testing;Genetics;Health Services;Human Genome;Maternal Health;Patient Safety;Pediatric;Pregnancy;Prevention;Women's Health Research

ORG_CITY: CLEVELAND

ORG_DEPT: SURGERY

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

ORG_STATE: OH

PHR: PROJECT NARRATIVE The early and accurate diagnosis of congenital abnormalities using prenatal genetic screens and diagnostic tests (PS&D) is pivotal for patients to make healthcare decisions that are informed by medical facts and their values about pregnancy, children, family, and reproduction. The goal of this study is to ensure that pregnant patients have the resources and support needed to access PS&D in an informed and evidence- based fashion by developing an innovative digital tool to support patients’ decision-making and contributing fundamental knowledge to advance decision science in a way that promotes patients' access to new prenatal applications of genomic science and technology. This study is significant because it will bridge the gap in existing data needed to overcome persistent barriers to patients' informed access to PS&D that remain unmet, addressing factors that have a critical impact on prenatal care quality, safety, and outcomes.

PI_NAMEs: FARRELL, RUTH  (contact)

PROGRAM_OFFICER_NAME: LOCKHART, NICOLE C

PROJECT_TERMS: accurate diagnosis;Address;Aneuploidy;Artificial Intelligence;Attitude;care delivery;Caring;Child;Clinical;Clinical Practice Guideline;Communication;Complex;Conflict (Psychology);Congenital Abnormality;Country;COVID-19 pandemic;Data;Decision Aid;Decision Making;Decision Support Systems;Diagnostic tests;digital;digital tool;Discipline of obstetrics;Early Diagnosis;education resources;Equity;Ethics;Event;evidence base;experience;Exposure to;Face;Family;fetal;follow-up;Genetic;Genetic Screening;genetic technology;genetic testing;genetic variant;genome sciences;Goals;Health;health care availability;health care quality;health information technology;Health Personnel;Healthcare;Human;improved;improved outcome;Individual;Infant;Infant Mortality;innovation;Insurance Coverage;Knowledge;Lead;Learning;learning engagement;Life;Measures;Medical;Medical Technology;Medicine;neonatal outcome;obstetric outcomes;Outcome;Outcome Measure;Parents;Pathway interactions;patient engagement;patient oriented;patient population;Patient-Focused Outcomes;Patients;Policies;preference;Pregnancy;pregnant;prenatal;Prenatal care;Prenatal Diagnosis;Probability;Procedures;Process;Provider;Public Health;Quality of Care;Quality of life;Reproduction;Resources;Risk;Safety;Science;Specialist;stem;Structure;Surveys;Technology;Testing;testing access;Time;tool;Training;treatment as usual;Uncertainty;Visit;Work;Workload

PROJECT_TITLE: Engaging Patients in Prenatal Genetic Testing Decisions as a Pathway to Improve Obstetric Outcomes