NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Genetics;Human Genome;Mental Health;Mental Illness;Neurosciences;Schizophrenia;Serious Mental Illness

ORG_CITY: PHILADELPHIA

ORG_NAME: THOMAS JEFFERSON UNIVERSITY

PHR: Project Narrative One of major postulates for the pathophysiology of schizophrenia is that glutamatergic signaling is altered in critical regions of the brain. Here we propose that another integral component of the glutamatergic receptor system, called mGluR5, is dysregulated in schizophrenia. In this proposal, we will identify the underlying mechanisms for mGluR5 hypoactivity and its important role in glutamatergic signaling, and the etiologic underpinnings that leading to changes in mGluR5 signaling in schizophrenia.

PI_NAMEs: HAHN, CHANG-GYU  (contact)

PROGRAM_OFFICER_NAME: MEINECKE, DOUGLAS L

PROJECT_TERMS: Age;Agonist;Algorithms;ATAC-seq;Attenuated;attenuation;Autopsy;Brain;Brain region;Calcineurin;Chromatin;cohort;comparison control;Complex;Coupling;Data;Data Set;density;desensitization;design;Diffusion;Disease;disease phenotype;Etiology;Event;Functional disorder;gene network;Genetic study;genetic variant;genome wide association study;genomic data;Genomics;glutamatergic signaling;Glutamates;Glycine;GRASP gene;Incubated;Individual;innovation;Intervention;Investigation;Label;Link;Macromolecular Complexes;Mediating;Methods;Mind;Molecular;Molecular Profiling;N-Methyl-D-Aspartate Receptors;N-Methylaspartate;novel;Pathway interactions;Patients;Pennsylvania;Phenotype;Phosphorylation;PIK3CG gene;postsynaptic;Prefrontal Cortex;Process;programs;protein complex;protein protein interaction;Proteins;Proteomics;psychiatric genomics;receptor;Receptor Activation;recruit;Reporting;response;risk variant;Role;Scaffolding Protein;Schizophrenia;schizophrenia risk;sex;Shotguns;Signal Transduction;Surface;System;Systems Biology;Tissues;trait;transcriptome sequencing;transcriptomics;Universities;Variant;Veterans;virtual

PROJECT_TITLE: mGluR5 hypoactivity is integral to glutamatergic dysregulation in schizophrenia

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


ADMINISTERING_IC: CA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics;Neuroblastoma;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: LUBBOCK

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PEDIATRICS

ORG_FIPS: US

ORG_NAME: TEXAS TECH UNIVERSITY HEALTH SCIS CENTER

ORG_STATE: TX

PHR: PROJECT NARATIVE Maintaining telomeres is necessary for cancers to grow and while most cancers use telomerase to extend telomeres, some use the alternate lengthening of telomeres (ALT) mechanism. We have assembled a large panel of ALT+ patient-derived cancer models growing in the laboratory and we will compare these across various cancer types and to non-ALT cancers. As we hypothesize that ALT+ cancers have common mechanisms of resistance to chemotherapy and also common sensitivity to novel drugs, we will test both standard drugs and novel investigational drugs against ALT+ cancer models to inform future clinical trials.

PI_NAMEs: REYNOLDS, CHARLES PATRICK (contact)

PROGRAM_OFFICER_NAME: VENKATACHALAM, SUNDARESAN

PROJECT_TERMS: Adult;ataxia telangiectasia mutated protein;ATM activation;ATRX gene;Biological Assay;Biological Markers;Cancer Biology;cancer cell;Cancer cell line;Cancer Histology;Cancer Model;Cancer Patient;cancer type;Cell Line;Cells;Chemicals;chemotherapy;Childhood;Chromosomes;Chronic;Clinical;clinical trial enrollment;Clinical Trials;Code;Colon Carcinoma;cytotoxic;Data;DAXX gene;Dependence;Detection;Development;DNA;DNA Damage;DNA Markers;DNA Repair;Dominant-Negative Mutation;drug standard;effective therapy;exome sequencing;Functional disorder;Future;Genetic Recombination;genome sequencing;genomic profiles;Histology;Human;inhibitor;Investigational Drugs;irinotecan;kinase inhibitor;knock-down;Laboratories;Malignant Childhood Neoplasm;Malignant Neoplasms;Modeling;Molecular;mutant;Mutation;Neuroblastoma;new therapeutic target;novel;novel therapeutics;Nucleoproteins;Osteosarcoma;Outcome;overexpression;participant enrollment;patient derived xenograft model;Patients;Phenotype;Phosphorylation;Phosphotransferases;Pre-Clinical Model;Prevalence;Prognosis;Proliferating;Proteins;refractory cancer;Resistance;resistance mechanism;response;Rhabdomyosarcoma;Ribonucleoproteins;Signal Transduction;small hairpin RNA;small molecule;Soft tissue sarcoma;Surveys;Telomerase;telomere;Telomere Maintenance;temozolomide;TERF1 gene;Testing;Therapeutic Effect;TP53 gene;transcriptome;transcriptome sequencing;triple-negative invasive breast carcinoma;tumor;Tumor Markers;Validation;whole genome;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Targeting Shared Vulnerabilities in Alternate Telomere Lengthening (ALT) Cancers

STUDY_SECTION: DT

STUDY_SECTION_NAME: Developmental Therapeutics Study Section[DT]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Lung;Pulmonary Fibrosis;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: SAN FRANCISCO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: Project Narrative Efforts to treat Idiopathic pulmonary fibrosis (IPF), the most common and deadly form of a large group of lung fibrotic diseases, have mostly targeted the scarring process. However, IPF is also characterized by the appearance of abnormal stem cell populations in areas of damage, a process known as metaplasia. The studies outlined in this proposal will test the idea that metaplasia can alter lung function in fibrotic diseases, and develop a pre-clinical pipeline to test therapies that can target metaplasia in patients with IPF.

PI_NAMEs: PENG, TIEN  (contact)

PROGRAM_OFFICER_NAME: LIN, SARA

PROJECT_TERMS: Address;Alveolar;Alveolus;analysis pipeline;antagonist;Antigens;Appearance;Area;Basal Cell;Bioinformatics;Biological Assay;BMP4;BMPR1A gene;Cell Separation;cell type;Cells;Cicatrix;Clinical;clinically relevant;Data;Deposition;directed differentiation;Disease;Engraftment;Epithelium;Erinaceidae;extracellular;Feedback;Fibrosis;fibrotic lung;fibrotic lung disease;Genetic;genetic approach;Human;idiopathic pulmonary fibrosis;immunodeficiency;In Vitro;in vivo;in vivo evaluation;inhibitor;Injury;insight;Ligands;loss of function;Lung;lung injury;Mesenchymal;Mesenchyme;Metaplasia;migration;Modeling;mortality;mouse model;Mus;novel;Organ;Organoids;Outcome;Pathologic;Patients;pharmacologic;Physiology;pre-clinical;Process;progenitor;Protein Engineering;Proteins;Pulmonary Fibrosis;pulmonary function;Recombinants;repaired;reverse genetics;Role;Sampling;screening;Severity of illness;Signal Transduction;Site;stem cell niche;stem cell population;targeted treatment;Testing;therapeutic target;tool;transcriptome sequencing;transdifferentiation;Up-Regulation

PROJECT_TITLE: Mesenchymal modulation of epithelial metaplasia in lung fibrosis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CVRS-N(03)]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Nutrition

ORG_CITY: ANN ARBOR

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative. The ability of cells and organisms to maintain metabolic homeostasis is fundamental to their health and long-term survival. This project will use recently developed tools to understand the role of a metabolic protein that has been shown to enhance health and longevity. The resulting data will help to understand how complex metabolic pathways are intertwined and how they can be leveraged to improve health outcomes.

PI_NAMEs: LEISER, SCOTT F (contact)

PROGRAM_OFFICER_NAME: FU, YI-PING

PROJECT_TERMS: Affect;age-related disease;Aging;Archaea;Biochemical Pathway;biological adaptation to stress;Biological Assay;Biology;Caenorhabditis elegans;Carbon;Cardiovascular Diseases;Cells;Collaborations;Communities;Complex;Data;Data Analyses;Dietary intake;dietary restriction;Disease;Drug Metabolic Detoxication;drug metabolism;endoplasmic reticulum stress;Energy Intake;Ensure;Environment;environmental intervention;Enzymes;Family;Fatty Acids;flavin-containing monooxygenase;FMO2;Food;gene therapy;Genes;Genetic;Genetic Epistasis;Goals;Health;Health Benefit;healthspan;Heavy Metals;Homeostasis;Homologous Gene;Human;improved;In Vitro;innovation;Intervention;knock-down;Knowledge;Kynurenine;Link;Lipids;Longevity;Longevity Pathway;Malnutrition;Measures;Mediating;Medical;Metabolic;Metabolic Pathway;Metabolism;metabolomics;Methylation;Methyltransferase;Modeling;Modification;Nature;Nematoda;novel;Organism;Outcome;Output;overexpression;Oxygen Isotopes;Oxygenases;Paraquat;Pathway interactions;Phase;Play;Process;Production;programs;Proteins;Publishing;Regulation;Reporting;Reproducibility;Research;Resistance;response;Role;Scientist;Source;Stress;success;System;targeted treatment;Techniques;Testing;therapy development;tool;Tryptophan;Work;Xenobiotics

PROJECT_TITLE: Flavin-containing monooxygenases in endogenous metabolism and aging

STUDY_SECTION: CMAD

STUDY_SECTION_NAME: Cellular Mechanisms in Aging and Development Study Section[CMAD]


ADMINISTERING_IC: MH

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Autism;Brain Disorders;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Mental Health

ORG_CITY: BOSTON

ORG_NAME: HARVARD MEDICAL SCHOOL

ORG_STATE: MA

PHR: Project Narrative Autism spectrum disorder (ASD) is common, often disabling, and lacks pharmacologic treatment for its core symptoms: impairment in social communication and restricted/repetitive behavior. We propose to apply three novel statistical and functional approaches to interpret ASD's common polygenic influences, with an emphasis on assessing the convergence of (i) polygenic risk and (ii) the more than 70 genes that have been associated with ASD through exome sequencing studies. These activities will improve our understanding of the genetic underpinnings of ASD, strengthen biological and therapeutic hypotheses, and generate methods applicable to the study of other neuropsychiatric conditions.

PI_NAMEs: WEINER, DANIEL  (contact)

PROGRAM_OFFICER_NAME: PINARD, COURTNEY ROSE

PROJECT_TERMS: Adult;Affect;autism spectrum disorder;Biological;Biological Process;Biology;brain tissue;career;causal variant;Cell Nucleus;cell type;Code;cohort;Communication;Data Set;Disabling;Disease;Doctor of Philosophy;Environment;exome sequencing;Family;Fellowship;Foundations;Functional disorder;Funding;Gene Expression;Gene Expression Regulation;Gene Targeting;Genes;Genetic;genetic risk factor;Genetic Variation;Genome;genome wide association study;genome-wide;Genomic Segment;Goals;Heritability;Impairment;improved;Mediating;Mediation;Mentorship;Methods;Modeling;neural;Neurons;neuropsychiatry;novel;Pathway interactions;Pharmacological Treatment;Physicians;Population;programs;rare variant;repetitive behavior;Research Training;Resources;Risk;Risk Factors;Scientist;single nucleus RNA-sequencing;social communication;statistics;Symptoms;Test Result;Testing;Therapeutic;therapeutic development;Tissues;Training;transcriptomics;transmission process;Uncertainty;United States National Institutes of Health;Untranslated RNA;Variant;Work

PROJECT_TITLE: Integrating common and rare genetic variation in autism spectrum disorder

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F08-M(20)L]


NIH_SPENDING_CATS: Cardiovascular;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Lung;Neurosciences

ORG_CITY: TAMPA

ORG_NAME: UNIVERSITY OF SOUTH FLORIDA

ORG_STATE: FL

PHR: The proposed research is relevant to public health because the identification of the mechanisms responsible for remodeled and aberrant pulmonary-cardiac reflexes in cardiovascular disease will ultimately lead to the development of effective therapies for the prevention of serious cardiovascular events caused by inhalation of pollution, as well as the identification of biomarkers for at-risk individuals. Thus, the proposed research is relevant to NHLBI’s mission to reduce morbidities and health care costs caused by cardiopulmonary disease.

PI_NAMEs: TAYLOR-CLARK, THOMAS EDWARD (contact)

PROGRAM_OFFICER_NAME: GALIS, ZORINA S

PROJECT_TERMS: Acute;afferent nerve;Air Pollutants;airway remodeling;Anesthetics;Animals;ANK1 gene;Atenolol;Atropine;biomarker identification;Bradycardia;C Fiber;Cardiac;Cardiovascular Diseases;Cardiovascular Models;Cardiovascular system;Cessation of life;Chronic;Clinical;Clinical Research;Dangerousness;Data;Development;effective therapy;Efferent Neurons;Efferent Pathways;Electrophysiology (science);Event;experience;Fiber;Functional disorder;Goals;Health;Health Care Costs;Heart failure;Hypertension;improved;Inbred SHR Rats;Individual;Inhalation;innovation;Irritants;Link;Lung;Mediating;Menthol;Mission;Modeling;Molecular;Morbidity - disease rate;Myocardial Infarction;National Heart, Lung, and Blood Institute;Nerve Growth Factor Receptors;neural network;Neurobiology;neuron component;neurophysiology;neurotrophic factor;Neurotrophic Tyrosine Kinase Receptor Type 2;Nociception;Nose;novel;Outcome;Ozone;Particulate Matter;Patients;pharmacologic;pollutant;Pollution;Population;Predisposition;Prevention therapy;Public Health;Pulmonary Heart Disease;Rattus;receptor;Receptor Activation;recruit;Reflex action;Renin-Angiotensin System;Research;respiratory;Risk;Risk Factors;Sensory;Signal Transduction;Stimulus;Tachyarrhythmias;Tachycardia;Techniques;Testing;Time;treatment choice;TRP channel;TRPA channel;Vanilloid;Ventricular Premature Complexes

PROJECT_TITLE: Remodeled airway irritant reflexes as a cause of serious cardiovascular events

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


ADMINISTERING_IC: AR

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Aging;Genetics;Regenerative Medicine;Sarcopenia;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human

ORG_CITY: LEXINGTON

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: Project Narrative Dysregulation of Muscle Stem Cell (MuSC) function contributes to many human diseases. Here, we describe a novel signaling pathway that stimulates MuSC differentiation, while suppressing self‐renewal. We propose that this pathway can be therapeutically exploited for the treatment of age‐associated muscle wasting.

PI_NAMEs: KIKANI, CHINTAN K (contact)

PROGRAM_OFFICER_NAME: LINDHURST, MARJORIE JEAN

PROJECT_TERMS: Acetylation;Acute;Adult;Affect;age-related muscle loss;Aging;aging process;Binding;Cell Count;Cell Physiology;Cells;Collaborations;Complex;Cues;Data;Disease;Epigenetic Process;Equilibrium;FRAP1 gene;Functional disorder;Genetic Transcription;Goals;Histone H3;Histones;Homeostasis;hormonal signals;Human;human disease;improved;in vivo;inhibitor;injured;Injury;Insulin;interest;Legal patent;Lysine;Maintenance;member;Messenger RNA;Metabolism;Methylation;Modeling;Modification;Molecular;mouse model;Mus;Muscle;muscle aging;Muscle Cells;Muscle function;muscle progenitor cell;Muscular Atrophy;Muscular Dystrophies;Myoblasts;myogenesis;Myogenin;Myopathy;Natural regeneration;normal aging;novel;novel therapeutics;Nucleosomes;Nutrient;overexpression;Pathway interactions;Phosphorylation;Phosphotransferases;Physiological;Play;Population;Process;programs;Proliferating;promoter;Property;Protein Kinase;Proteins;Publishing;Reagent;recruit;regeneration function;regeneration potential;regenerative;Repression;Research;Research Proposals;response;Role;sarcopenia;self-renewal;Signal Pathway;Signal Transduction;stem cell differentiation;stem cell exhaustion;stem cell fate specification;stem cell function;stem cells;Testing;Therapeutic;transcription factor;Transcription Process;Transferase;Trauma;Wasting Syndrome;WD Repeat

PROJECT_TITLE: Epigenetic control of muscle stem cell function by PASK-Wdr5 signaling

STUDY_SECTION: SMEP

STUDY_SECTION_NAME: Skeletal Muscle and Exercise Physiology Study Section[SMEP]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

ORG_DEPT: PHYSICAL MEDICINE & REHAB

PHR: Peripheral artery disease (PAD) significantly affects aging populations and results in functional impairment and mobility loss. Few medical therapies are currently available to treat PAD because the underlying pathology in calf muscle is not understood. The goal of this study is identify aberrant properties of muscle to aide in the development of new targeted interventions to improve walking ability in individuals with PAD.

PI_NAMEs: DUPONT-VERSTEEGDEN, ESTHER E (contact);KOSMAC, KATE

PROGRAM_OFFICER_NAME: GAO, HONGWEI

PROJECT_TERMS: Affect;Aging;Ankle;Area;Atrophic;Autophagocytosis;biobank;Biogenesis;Biological Markers;Biological Process;Biological Specimen Banks;Biopsy;Blood flow;Characteristics;Classification;Clinical;Clinical Trials;cohort;coping;Data;Defect;Denervation;Development;Diagnosis;Diagnostic;Disability prevention;Disease;Disease Progression;Effectiveness;efficacious intervention;exercise intervention;Fiber;follow-up;Foundations;functional decline;Functional impairment;functional improvement;functional outcomes;Future;Gait abnormality;Gastrocnemius Muscle;Goals;Grouping;improved;indexing;Individual;Injury;Intervention;Ischemia;Lower Extremity;Measures;Medical;Mitochondria;mitochondrial autophagy;mitochondrial dysfunction;Modeling;Morphology;Motor Neurons;Muscle;Muscle Fibers;Myopathy;Myosin Heavy Chains;Myosin Type I;NCAM1 gene;novel;Outcome;oxidative damage;Oxidative Stress;Participant;Pathology;Patients;Performance;Perfusion;Peripheral arterial disease;Persons;pharmacologic;Phase;Population;predictive modeling;preservation;Property;Proteins;Recycling;reinnervation;Reperfusion Injury;Reperfusion Therapy;Reporting;response;Sampling;Severity of illness;Skeletal Muscle;Testing;Theoretical model;tool;Training;Walking;walking performance

PROJECT_TITLE: Novel gastrocnemius muscle characteristics in peripheral artery disease patients associated with impaired functional performance

STUDY_SECTION: ASG

STUDY_SECTION_NAME: Aging Systems and Geriatrics Study Section[ASG]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Genetics;Immunization;Infectious Diseases;Lung;Pediatric;Pneumonia;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_CITY: NEW YORK

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: Narrative This project aims to understand how the leading pathogen Streptococcus pneumoniae is transmitted from host-to-host. We will identify bacterial genes that contribute to transmission in an animal model as well as in natural transmission. The bacterial products we identify will then be tested as novel vaccine antigens to block transmission – a critical step for the success of the organism.

PI_NAMEs: WEISER, JEFFREY NEAL (contact)

PROGRAM_OFFICER_NAME: UPADHYAY, MEENU MISHRA

PROJECT_TERMS: Affect;Animal Model;Bacterial Genes;Bacterial Genome;Binding;Biology;Candidate Disease Gene;Child;Childhood;cohort;Communities;contagion;Data;density;Disease;disorder prevention;Enzymes;Event;experience;Frequencies;Funding;gene product;Genes;Genetic;genetic element;Genetic Screening;Genome;genome wide association study;Genomic Library;genomic locus;genomic variation;Glycoproteins;Goals;Herd Immunity;host colonization;Human;Humoral Immunities;Immunity;Immunization;immunogenic;improved;Incidence;Infant;infant monitoring;Infection;Inflammation;insight;Interruption;Investigation;Life Cycle Stages;Maps;microbial;Modeling;Molecular;mouse model;Mucins;Mucosal Immunity;Mucositis;Mucous body substance;Mus;mutant;nasal swab;Nose;novel;novel vaccines;Organism;pathogen;Pathogenesis;Pneumococcal conjugate vaccine;Pneumococcal Infections;Polysaccharides;Population;Prevalence;Prevention;rational design;Respiratory System;Role;Serotyping;Streptococcus pneumoniae;Streptococcus pneumoniae plY protein;success;Surface;Testing;Toxin;transmission blocking;transmission process;transmission-blocking vaccine;transposon sequencing;unvaccinated;Vaccinated;Vaccine Antigen;vaccine discovery;vaccine evaluation;vaccine-induced immunity;whole genome

PROJECT_TITLE: Targeting Pneumococcal Transmission

STUDY_SECTION: HIBP

STUDY_SECTION_NAME: Host Interactions with Bacterial Pathogens Study Section[HIBP]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: AUSTIN

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because defects in membrane remodeling underlie debilitating diseases from cancer to neurological disorders, and because membrane trafficking vesicles serve as the cellular entry mechanism for both harmful pathogens and therapeutic drugs. Therefore, the proposed research on the basic physical mechanisms underlying membrane remodeling is relevant to the part of NIH’s mission that seeks to develop fundamental knowledge that will help to reduce the burdens of human disability and disease. Ultimately, it is envisioned that a fundamental understanding of membrane remodeling will enable therapeutic manipulation of membrane traffic and other points of intersection between membranes and disease.

PI_NAMEs: STACHOWIAK, JEANNE CASSTEVENS (contact)

PROGRAM_OFFICER_NAME: NIE, ZHONGZHEN

PROJECT_TERMS: Area;Behavior;Biological Process;Biology;Cell Physiology;Cells;Clathrin;Coupled;Defect;Diabetes Mellitus;disability;Disease;driving force;Endocytosis;Event;Filopodia;flexibility;Human;human disease;In Vitro;Individual;insight;Integral Membrane Protein;Knowledge;Liquid substance;Malignant Neoplasms;Mediating;Membrane;Membrane Protein Traffic;Mission;Modeling;Molecular;Needles;Nervous System Disorder;novel;pathogen;Pathway interactions;Pharmaceutical Preparations;pressure;Proteins;Public Health;receptor recycling;Research;Role;scaffold;Shapes;Structure;Structure-Activity Relationship;Surface;Tertiary Protein Structure;Therapeutic;trafficking;United States National Institutes of Health;Vesicle;Virus Replication;Work

PROJECT_TITLE: Protein Networks as Synergistic Drivers of Membrane Remodeling

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-Q(55)R]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Bioengineering

ORG_CITY: SALT LAKE CITY

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE The tectorial membrane (TM) plays important roles in frequency tuning and amplification of sound waves. The TM displays sophisticated ultrastructure and domain-specific organization of matrix architecture. By understanding how the specific matrix structure of the TM matrix is organized, our research has the potential to provide novel insights into the morphogenesis process and the physiological functions of the TM in normal and disease conditions.

PI_NAMEs: PARK, SUNG JIN  (contact)

PROGRAM_OFFICER_NAME: FREEMAN, NANCY

PROJECT_TERMS: 3D Print;Apical;Architecture;Auditory;Biological Assay;C-terminal;Cell surface;Cells;Cochlear duct;Collagen;Collagen Fibril;Complex;Data;Development;Developmental Biology;Diffusion;Disease;Exhibits;extracellular;Extracellular Matrix;Extracellular Space;Fiber;Frequencies;Glycosylphosphatidylinositols;GPI Membrane Anchors;Growth;hearing impairment;In Vitro;in vitro Assay;in vivo;Individual;Inherited;insight;limbal;Location;malformation;Mediating;Modeling;Molecular;molecular dynamics;Morphogenesis;novel;Organ of Corti;Pattern;Peptides;Physiological;Play;polymerization;Polymers;Presbycusis;prevent;Printing;Process;Property;Proteins;Radial;Reconstructive Surgical Procedures;regenerative therapy;Research;Role;Shapes;sound;Stereotyping;Structure;Surface;tectorial membrane;Testing;Thinness;Time;Tissue Engineering

PROJECT_TITLE: Molecular mechanisms underlying morphogenesis of the tectorial membrane

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


ADMINISTERING_IC: HG

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Biotechnology;Genetics;Human Genome;Social Determinants of Health

ORG_CITY: SANTA CRUZ

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF CALIFORNIA SANTA CRUZ

PHR: PROJECT NARRATIVE The Research Mentoring Internship (RMI) Program at UC Santa Cruz offers mentored research training, financial support, and professional development to students pursuing careers in genomic science or in the analysis of the ethical, legal, and social implications of that research. The RMI improves equity and access to careers in genomic science by contributing to the number of academically talented and underrepresented minority (URM) undergraduate students who successfully complete degrees in genomic science. Our efforts are valuable in terms of social justice, and the students who graduate from our programs constitute a valuable contribution to the American workforce, bringing skill, talent, and diverse perspectives to fields of knowledge that promise to dramatically benefit human health.

PI_NAMEs: BROOKS, ANGELA NORIE (contact);RAMON, MARINA L

PROGRAM_OFFICER_NAME: XIRASAGAR, SANDHYA

PROJECT_TERMS: Affinity;American;Area;aspirate;Bioethics;Bioinformatics;Black, Indigenous, People of Color;broadening participation research;California;candidate identification;career;Career Mobility;cohort;college;Communities;community building;community college;Degree Completion;Development;disabled students;Discrimination;diversity and inclusion;Doctor of Philosophy;Dryness;Education;education research;Educational Curriculum;Educational workshop;empowerment;Enrollment;Ensure;Environment;Equity;Ethical Analysis;ethical, legal, and social implication;Ethics;experience;Extramural Activities;Faculty;faculty mentor;faculty research;Family;Financial Support;Fostering;Funding;Funding Agency;Generations;genome sciences;Genomics;Goals;graduate research fellowship program;graduate school;graduate school preparation;Health;Healthcare;higher education;Hispanic-serving Institution;Hour;Household;Human;improved;Institution;Interdisciplinary Communication;Internships;Investigation;Justice;Knowledge;Learning Disabilities;Low income;member;Mentors;Minority;Mission;outreach;Pathway interactions;payment;peer coaching;peer networks;physically handicapped;Policies;Population;portability;Preparation;programs;prospective;Readiness;Recording of previous events;recruit;Research;Research Support;Research Training;retention rate;Scholarship;Schools;Science;Series;skills;social implication;Social Justice;Social Responsibility;Social Sciences;STEM research;Students;success;summer research;Supervision;symposium;Talents;tool;Training;Training Support;transfer student;undergraduate student;Underrepresented Minority;underrepresented minority student;Underserved Population;underserved students;United States National Institutes of Health;Universities;university student;Vocational Guidance

PROJECT_TITLE: UCSC Research Mentoring Internship Program: An Initiative to Increase Diversity and Inclusion in Genomics Research


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Hepatitis;Liver Disease;Nutrition

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Relevance to Public Health Metabolic and chronic liver disease are among the leading causes of death in the US, and therefore creates a significant burden to the national health system. Cholestasis (the accumulation of bile acids) is one of the most common causes of chronic liver disease and there are limited options for treatments. Our discovery that ABCD3 regulates bile acid and lipid metabolism will advance our fundamental understanding of physiologic processes, elucidate mechanisms for current therapies and may reveal novel opportunities for therapeutic intervention.

PI_NAMEs: TARLING, ELIZABETH JOANNA (contact);VALLIM, THOMAS A

PROGRAM_OFFICER_NAME: BURGESS-BEUSSE, BONNIE L

PROJECT_TERMS: Acute;Address;Adult;Alcohol consumption;Animals;ATP-Binding Cassette Transporters;bile acid metabolism;Bile Acids;Bile fluid;Biliary;branched chain fatty acid;Cannulations;Cause of Death;Cholestasis;chronic liver disease;Classification;Clustered Regularly Interspaced Short Palindromic Repeats;CRISPR/Cas technology;Defect;design;Development;Disease;Disease Progression;disorder prevention;effective therapy;Embryo;Enzymes;Event;Fibrosis;Functional disorder;Gene Expression;Genes;Health;Health system;Hepatic;Hepatomegaly;Histologic;Histopathology;Human;Hybrids;Impairment;in vitro Assay;in vivo;Inbred Strains Mice;lipid metabolism;lipid transport;lipidome;lipidomics;Lipids;Liver;Liver diseases;liver injury;loss of function;Measures;Metabolic;Metabolism;Methods;Molecular;Mus;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;novel;Nutrient;Onset of illness;Pathogenesis;Pathogenicity;Pathology;Pathway interactions;peroxisome;Physiological Processes;Plasma;prevent;Progressive intrahepatic cholestasis;protein expression;Proteins;Proteomics;Public Health;Regulation;Reporting;Resistance;Role;Systems Biology;Testing;Therapeutic Intervention;tool;Triglycerides;Very Long Chain Fatty Acid;Virus Diseases;western diet;Wild Type Mouse

PROJECT_TITLE: ATP Binding Cassette Transporters in Health and Disease

STUDY_SECTION: XNDA

STUDY_SECTION_NAME: Xenobiotic and Nutrient Disposition and Action Study Section[XNDA]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Data Science;Dementia;Genetics;Machine Learning and Artificial Intelligence;Neurodegenerative;Neurosciences

ORG_CITY: LA JOLLA

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

PHR: PROJECT NARRATIVE This project focuses on discovering new treatments for Alzheimer’s Disease. We specifically are looking for drugs that are already approved (or were previously tested) to treat other diseases to see if they can be beneficial for Alzheimer’s Disease patients. We will make and test predictions about which chemical compounds will have benefit, either alone or in combination.

PI_NAMEs: SU, ANDREW I (contact)

PROGRAM_OFFICER_NAME: ARUNKUMAR, NANDINI

PROJECT_TERMS: Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease patient;Area;Biological Assay;Blue Cross;Blue Shield;candidate identification;Cell Line;Cells;Chemicals;Clinical;clinical development;Collection;Communities;Control Groups;cost;Data;Data Set;Databases;Diagnosis;Disease;Disease Outcome;Drug Prescriptions;drug repurposing;Drug usage;experimental study;FDA approved;follow-up;Follow-Up Studies;Foundations;Future;Gene Expression;Gene Expression Profile;Genetic Transcription;Goals;Graph;Health;human induced pluripotent stem cells;In Vitro;in vitro Assay;in vivo;Incidence;Individual;insurance claims;interest;Knowledge;knowledge graph;knowledge network;Libraries;Machine Learning;machine learning method;Manuals;Medical;Methods;Mining;Neurons;novel therapeutics;Organoids;Outcome;Output;Pharmaceutical Preparations;Pharmacy facility;Positioning Attribute;pre-clinical;preclinical development;Property;Publishing;Recommendation;Research;Resources;screening;Severities;small molecule;Source;Statistical Data Interpretation;symposium;System;Testing;Therapeutic;tool;Training;training data;transcriptome sequencing;trend;United States National Institutes of Health;Validation;validation studies;Work

PROJECT_TITLE: Compound repositioning for Alzheimer's Disease using knowledge graphs, insurance claims data, and gene expression complementarity


NIH_SPENDING_CATS: Aging;Cancer;Genetics;Hematology;Prevention;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: Aurora

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Aging is highly associated with increased leukemia risk. A better understanding of how aging-associated inflammatory changes in the bone marrow microenvironment could promote leukemogenesis will be critical for the development of new prevention and treatment interventions that restore a healthy tissue landscape. While we may not be able to prevent the accumulation of oncogenic mutations in blood-forming hematopoietic stem and progenitor cells over a lifetime, modulating tissue microenvironments to reduce selection for oncogenically mutated cells could significantly reduce leukemia risk and improve health-span of our aging population.

PI_NAMEs: DEGREGORI, JAMES V (contact)

PROGRAM_OFFICER_NAME: GUO, MAX

PROJECT_TERMS: Age;age related changes;aged;Aging;aging mechanism;aging population;aging related;Apical;Automobile Driving;B-Lymphocytes;Blood;bone aging;Bone Marrow;cancer cell;cancer risk;carcinogenicity;Cell Compartmentation;Cells;Development;Directed Molecular Evolution;Disease;Elderly;Environment;environmental change;Epigenetic Process;Event;Evolution;fitness;Gene Expression;Genetic;Goals;healthspan;Hematopoiesis;Hematopoietic;hematopoietic hierarchy;Hematopoietic Neoplasms;Hematopoietic stem cells;human old age (65+);Impairment;improved;Incidence;Inflammation;Inflammatory;Intervention;leukemia;leukemogenesis;Life;Link;Malignant Neoplasms;Modeling;Modification;mouse model;mutant;Mutate;Mutation;Natural Selections;Oncogenic;Organ Model;pharmacologic;Phenotype;Population;prevent;Prevention;Process;Risk;Risk Reduction;Role;self-renewal;Signal Transduction;Somatic Cell;stem;stem cell differentiation;stem cells;success;Testing;therapy development;Time;Tissues;tumor microenvironment;tumorigenesis

PROJECT_TITLE: Aged tissue environments as drivers of oncogenic adaptation in hematopoiesis

STUDY_SECTION: TME

STUDY_SECTION_NAME: Tumor Microenvironment Study Section[TME]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: OVERALL – PROJECT NARRATIVE The mission of the University of Virginia Cancer Center (UVACC) is to eliminate the threat of cancer, with skilled, compassionate care for the patients of today and with research and education for the patients of the future in an environment that promotes diversity, equity, and inclusion. UVACC Members draw on the deep resources of the University of Virginia to identify, analyze, and validate some of the most significant targets for cancer therapy, diagnosis and prevention, and to speed their translation to clinical application for the benefit of the people of the catchment area and beyond.

PI_NAMEs: LOUGHRAN, THOMAS P. (contact)

PROGRAM_OFFICER_NAME: HE, MIN

PROJECT_TERMS: Acceleration;Achievement;acronyms;anti-cancer research;Area;Arts;Award;Basic Science;biobank;Biostatistics Shared Resource;Cancer Biology;Cancer Burden;cancer care;Cancer Center;Cancer Center Support Grant;Cancer Control;Cancer Patient;cancer prevention;Cancer Research Project;cancer risk;career;Caring;Catchment Area;Clinical;clinical application;Clinical Cancer Center;Clinical Data;Clinical Investigator;Clinical Protocols;Clinical Research;Clinical Trials;Collaborations;college;Communities;community engagement;Community Healthcare;Community Outreach;Comprehensive Cancer Center;data management;design;Development;Diagnosis;Direct Costs;Discipline of Nursing;Disclosure;Doctor of Philosophy;Education;Engineering;Enrollment;Environment;Epigenetic Process;equity, diversity, and inclusion;Evaluation;Faculty Recruitment;Flow Cytometry;Foundations;Funding;Future;Goals;Health Professional;Immunologics;infrastructure development;instrumentation;Intervention Studies;Knowledge;Laboratories;Leadership;Legal patent;leukemia;Licensing;Malignant Neoplasms;medical schools;Medical Students;meetings;member;Metastatic malignant neoplasm to brain;Metastatic Prostate Cancer;Microscopy;Mission;Molecular;Molecular Genetics;Monitor;obesity risk;Outcome;Participant;Patient Education;Patients;Peer Review;Peer Review Grants;Persons;Population;population based;population health;Population Sciences;Postdoctoral Fellow;Prevention;Productivity;programs;protocol development;Protocols documentation;Public Health;Publications;Publishing;Request for Applications;Research;Research Activity;research facility;Research Personnel;Resource Sharing;Risk Reduction;rural area;Rural Community;rural underserved;Science;Scientist;screening;Services;skills;Source;Speed;System;targeted cancer therapy;Technology;Therapeutic;Tissues;Tobacco Use Cessation;Training;Training and Education;Translational Research;translational scientist;Translations;treatment trial;undergraduate student;underserved rural area;Universities;University of Virginia Cancer Center;University resources;Urothelium;Virginia

PROJECT_TITLE: University of Virginia Cancer Center Support Grant

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


ORG_CITY: LITTLE ROCK

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIV OF ARKANSAS FOR MED SCIS

ORG_STATE: AR

PHR: PROJECT NARRATIVE  The majority of donor kidneys require cold storage prior to transplantation, but this process usually leads to renal damage. At least 20% of cadaver donor kidneys cannot be used, and many have suboptimal results, due to cold storage activating cellular pathways that damage kidney tissue. Our goal is to identify these cold storage- induced pathways and develop new therapeutic strategies to successfully prevent damage to increase viability and to improve kidney function after transplantation.

PI_NAMEs: PARAJULI, NIRMALA  (contact)

PROGRAM_OFFICER_NAME: GOSSETT, DANIEL ROBERT

PROJECT_TERMS: Affect;Allografting;Animal Model;Binding;Bioinformatics;Cadaver;Cell Survival;cell type;Cells;Clinical;clinically relevant;Cryopreservation;Data;Disease;Drug Targeting;End stage renal failure;Exhibits;Family;Functional disorder;Generations;Genetic;Goals;Harvest;Heat shock proteins;Heat-Shock Proteins 70;Homologous Gene;Housekeeping;Hsc70 protein;HSF1;HSP72 protein;Human;human disease;human model;Immune system;immunoregulation;Impairment;improved;improved outcome;In Vitro;in vivo;Inflammation;inflammatory modulation;Inflammatory Response;Infusion Pumps;inhibitor;Injury;Injury to Kidney;insight;Kidney;kidney cell;Kidney Transplantation;Link;MAP Kinase Gene;Mass Spectrum Analysis;Mediating;Mediator;member;misfolded protein;Mitogen-Activated Protein Kinase Inhibitor;Modeling;Molecular;mortality;multicatalytic endopeptidase complex;natural hypothermia;novel;novel therapeutic intervention;Organ;Outcome;p38 Mitogen Activated Protein Kinase;Pathogenesis;Pathologic;Pathway interactions;Patients;Perfusion;Persons;pharmacologic;Phosphorylation;Play;preservation;prevent;Process;protein degradation;Proteins;proteostasis;proteostasis loss;Rattus;recruit;renal damage;Renal function;Renal Tissue;Reperfusion Therapy;Role;Site;Small Interfering RNA;Stress;targeted treatment;Testing;Therapeutic;therapeutic target;tissue injury;Tissues;transcription factor;Translating;transplant model;Transplant Recipients;Transplantation;Up-Regulation;Work

PROJECT_TITLE: Targeting heat shock protein 72 to improve renal function after transplantation

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


NIH_SPENDING_CATS: Cancer

PHR: Project Narrative: Per PAR-20-043, Project Narrative is not completed.

PI_NAMEs: HALME, DINA GOULD (contact)

PROJECT_TERMS: acronyms;Administrator;anti-cancer research;Applied Research;Area;Association of American Cancer Institutes;Award;Budgets;cancer care;Cancer Center;Cancer Center Support Grant;Capital;Characteristics;Clinical Research;Collaborations;Communication;community engagement;Community of Practice;Community Outreach;Development;Engineering;Evaluation;Faculty Recruitment;faculty support;Fostering;Funding;Funding Opportunities;Goals;Grant;Health system;Immunologics;Infrastructure;Institution;interdisciplinary collaboration;Internet;Leadership;Malignant Neoplasms;Master of Public Health;medical schools;meetings;member;Mission;Monitor;Newsletter;Occupational activity of managing finances;Oncology;Outcome;Patient Care;Philanthropic Fund;Play;Policies;population health;precision medicine;Preparation;Printing;Process;programs;recruit;Reporting;Research;research and development;Research Personnel;Research Project Grants;Research Proposals;Resource Sharing;Resources;Role;Schools;Services;Strategic Planning;Therapeutic;Training;translational pipeline;Translational Research;University adminstration;University of Virginia Cancer Center;Work

PROJECT_TITLE: Admin Core


PI_NAMEs: BOUTON, AMY H. (contact)

PROJECT_TERMS: acronyms;Age;American Cancer Society;American Heart Association;anti-cancer research;Applied Research;Arts;Award;Biomedical Engineering;Cancer Biology;Cancer Center Support Grant;cancer education;care outcomes;career;career development;Career Mobility;Catchment Area;Clinical;Clinical Research;Collaborations;Colorectal Cancer;Communities;community center;community engagement;Community Healthcare;Community Outreach;Continuing Education;Data Science;design;Development;Development Plans;Education;Educational Curriculum;Educational workshop;elementary school;Engineering;Faculty;falls;Fellowship;Foundations;Goals;Grant;Hand;Health Personnel;Health Professional;Health Sciences;High School Student;Individual;Infrastructure;innovation;Institution;K-12 Education;Leadership;Learning;Malignant Neoplasms;Master of Public Health;Master of Science;Medical;medical schools;Medical Students;meetings;member;Mentors;Minority-Serving Institution;Mission;population health;Positioning Attribute;Postdoctoral Fellow;Program Development;programs;Publications;Records;Research;Research Project Grants;Resource Sharing;Science;Scientist;Site;Students;success;summer research;symposium;synergism;Telemedicine;Time;Training;Training Activity;Training and Education;Training Programs;University of Virginia Cancer Center;Virginia;Work

PROJECT_TITLE: Cancer Research Training & Education Core


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Prevention

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: NEW YORK UNIVERSITY

PHR: Mitochondrial permeability transition is stress-induced damage to the mitochondrial inner membrane that disrupts mitochondrial function and leads to cell death. Our proposal aims to investigate molecular mechanisms underlying permeability transition. This knowledge will help to understand one of the central pathological events that cause damage during the stroke and heart attack.

PI_NAMEs: PAVLOV, EVGENY  (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TERMS: Animal Diseases;Biological Assay;Calcium;Cell Death;Cell Membrane Permeability;Cells;Cessation of life;Complex;Coupled;Disease;Drug Targeting;electrical potential;Electrophysiology (science);Energy-Generating Resources;Ensure;Eukaryotic Cell;Event;Functional disorder;Generations;Goals;Homeostasis;Inner mitochondrial membrane;Knowledge;Link;Measurement;Measures;Membrane Potentials;Methods;Mitochondria;mitochondrial membrane;Modeling;Molecular;Myocardial Infarction;Nerve Degeneration;oxidation;Oxidative Phosphorylation;patch clamp;Pathologic;Pathway interactions;Permeability;Phosphorylation;Potential Energy;prevent;Prevention;Process;programs;Regulation;Research;Respiratory Chain;Severities;Stress;Stroke;Therapeutic;therapeutic development;Tissues

PROJECT_TITLE: Molecular mechanisms of the mitochondrial permeability transition

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


PI_NAMEs: BUSHWELLER, JOHN HACKETT (contact)

PROJECT_TERMS: acronyms;Acute Myelocytic Leukemia;Adenoid Cystic Carcinoma;Agammaglobulinaemia tyrosine kinase;anti-cancer research;Antineoplastic Agents;Area;Automobile Driving;base;Basic Science;biobank;Biochemistry;Biology;Cancer Biology;Cancer Center;Cancer Center Support Grant;cancer heterogeneity;cancer therapy;cancer type;Catchment Area;Cells;Chemicals;Chromosomes;Chronic Lymphocytic Leukemia;Clinic;clinical application;Clinical Trials;Collaborations;Cryoelectron Microscopy;design;Development;Diacylglycerol Kinase;Direct Costs;Disease;drug development;drug discovery;Early Therapeutic-Clinical Trials Network;Endothelial Cells;Epigenetic Process;experience;Exposure to;Feeds;Flow Cytometry;Funding;Genetic;Goals;Grant;Head and Neck Squamous Cell Carcinoma;Homeostasis;Individual;Industry;inhibitor;insight;Investments;knock-down;Knock-out;Knowledge;Lead;Lipids;Malignant Breast Neoplasm;Malignant Neoplasms;Mantle Cell Lymphoma;member;Methods;Microscopy;Molecular;Molecular Genetics;Multi-Institutional Clinical Trial;Mutagenesis;Mutation;Neoplasm Metastasis;new therapeutic target;Normal tissue morphology;novel;novel therapeutic intervention;novel therapeutics;Pathway interactions;Peer Review;Pharmacology;Phosphotransferases;Pre-Clinical Model;Principal Investigator;programs;Proteins;Publications;receptor;Research;research facility;Research Personnel;Resource Sharing;Schools;Science;Signal Transduction;Site;small molecule;small molecule therapeutics;structural biology;Structure;Systems Biology;Therapeutic;therapeutic development;Therapeutic Intervention;therapeutic target;Tissues;tool development;Training and Education;transcription factor;Translational Research;tumor;tumor initiation;tumor microenvironment;United States National Academy of Sciences;University of Virginia Cancer Center;Validation;Work

PROJECT_TITLE: CBIO - Project


NIH_SPENDING_CATS: Aging;Biomedical Imaging;Clinical Research;Nutrition;Physical Activity;Prevention

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Narrative: The objective of this proposal is to develop, optimize and validate a novel noninvasive MRI method for creatine imaging to study muscle specific oxidative phosphorylation (OXPHOS). To validate and demonstrate the translational utility of the method, the effects of age, sex, race and physical activity on creatine metabolism in muscle will be measured. Successful accomplishment of the goals of this project will lead to a noninvasive diagnostic tool for studying abnormal muscle specific OXPHOS, without the invasiveness of biopsy-based approaches. In addition, the method can help evaluate the efficacy of potential therapies targeting creatine kinase metabolism in a variety of conditions including aging and myriad other conditions.

PI_NAMEs: REDDY, RAVINDER  (contact)

PROGRAM_OFFICER_NAME: BOYCE, AMANDA T

PROJECT_TERMS: Adenosine Triphosphate;Adult;Aerobic;Affect;Age;age effect;age group;Aging;Amines;Anatomy;Bioenergetics;Biopsy;Blood flow;Cell Respiration;Chemicals;Chronic;Chronic Disease;Clinical;clinically relevant;cohort;Computer software;Creatine;Creatine Kinase;Data;data exchange;design;Diabetes Mellitus;diagnostic tool;Disease;efficacy evaluation;Elderly;Evaluation;Exercise;Fiber;Functional disorder;Future;Gastrocnemius Muscle;Genetic;Goals;Human;Image;imaging biomarker;Imaging Techniques;improved;in vivo;indexing;Individual;Kinetics;Location;magnetic field;Magnetic Resonance Imaging;Magnetic Resonance Spectroscopy;Maps;Measures;Metabolic;Metabolism;Methods;Mitochondria;Mitochondrial Diseases;MM form creatine kinase;Modality;Monitor;Motion;Muscle;muscle form;Muscle function;muscle metabolism;Muscle Mitochondria;Muscular Dystrophies;Neuromuscular Diseases;non-invasive imaging;noninvasive diagnosis;novel;nutrition;Outcome;Oxidative Phosphorylation;Oxidative Phosphorylation Deficiency;Peripheral arterial disease;Phosphocreatine;Phosphorus;Physical activity;Population;Positioning Attribute;Procedures;Property;Publishing;quantitative imaging;Race;Recovery;Reproducibility;Research;Resolution;response;Rest;sedentary lifestyle;sex;Signal Transduction;Skeletal Muscle;Slice;Soleus Muscle;Source;spatiotemporal;Specificity;Strenuous Exercise;Supplementation;targeted treatment;Techniques;Technology;temporal measurement;Testing;Time;tool;treatment strategy

PROJECT_TITLE: In vivo Mapping of Muscle Specific Metabolism

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


NIH_SPENDING_CATS: Aging;Prevention;Sarcopenia

ORG_DEPT: OTHER HEALTH PROFESSIONS

PHR: Project Narrative Sarcopenia represents a highly prevalent, unresolved medical issue in an increasing aging and sedentary population. A pharmacologic therapy for muscle loss does not exist, and current diet/exercise therapeutic approaches are often ineffective and/or unfeasible. Findings from these studies may lead to novel approaches for the treatment of skeletal muscle atrophy.

PI_NAMEs: DRUMMOND, MICAH J;FUNAI, KATSUHIKO  (contact)

PROJECT_TERMS: Acceleration;Acyltransferase;Affect;Age;Aging;aging population;Aldehydes;ATG3 gene;Atrophic;Autophagocytosis;Autophagosome;Carboxy-Lyases;Cardiovascular Diseases;Cell Death Induction;cell injury;Cell Size;cell type;Clinical;Collection;Data;Diameter;diet and exercise;Enzymes;experimental study;glutathione peroxidase;healthy aging;Hydroxyl Radical;In Vitro;in vivo;inhibition of autophagy;Knowledge;Lecithin;Lipid Peroxides;Lipids;Lysophosphatidylcholines;Lysosomes;Maintenance;Medical;Membrane;Metabolic Diseases;Mitochondria;Mobility decline;Modeling;Molecular;Mus;muscle aging;Muscle Cells;Muscle Fibers;muscle form;Muscle function;muscle strength;Muscle Weakness;Muscular Atrophy;Nature;novel strategies;old mice;overexpression;Oxidative Stress;Pathway interactions;pharmacologic;Phosphatidylethanolamine;Phosphatidylserines;Phospholipids;pi bond;Play;Polyunsaturated Fatty Acids;Population;prevent;Production;Protein Biosynthesis;protein degradation;Proteolysis;Quality of life;Reaction;Reactive Oxygen Species;Role;sarcopenia;sedentary;Signal Transduction;Skeletal Muscle;skeletal muscle wasting;Source;Stress;Testing;Therapeutic;Water

PROJECT_TITLE: LOOH-induced muscle atrophy with age


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Rare Diseases

PI_NAMEs: STUKENBERG, P. TODD  (contact)

PROJECT_TERMS: acronyms;Aneuploidy;Architecture;Area;base;Basic Science;Binding;Bioinformatics;bioinformatics pipeline;Biological;Biology;BRAF gene;Cancer Biology;cancer cell;Cancer Center;Cancer Center Support Grant;Cancer Control;cancer predisposition;carcinogenicity;Cell Cycle;Cell Cycle Progression;Cells;Chromatin;Chromosomal Instability;Chromosome Fragile Sites;Chromosomes;Clinical;Clinical Trials;Combined Modality Therapy;Communities;community engagement;Community Outreach;Computational Biology;Computer Models;Computer software;computerized tools;crosslink;Data;Data Set;deep sequencing;Defect;Development;Direct Costs;Disease;DNA;DNA biosynthesis;DNA Damage;DNA metabolism;DNA Repair;DNA Sequence Rearrangement;DNA Structure;Epigenetic Process;epigenetic therapy;epigenomics;extracellular;Flow Cytometry;Focused Ultrasound;Funding;Gene Expression;Gene Expression Regulation;Gene Mutation;Genetic Transcription;Genome Stability;genome-wide;genomic data;Genomics;Glioblastoma;Goals;Grant;Harvest;Heritability;Immunologics;Individual;Infrastructure;inhibitor;insight;Kinetics;Lead;Lung Adenocarcinoma;Malignant Neoplasms;medical schools;Melanoma;member;Methods;MicroRNAs;Microscopy;Mitosis;Molecular;Molecular Genetics;Mutation;nanoparticle;novel;Oncogenes;Pathogenesis;Pathway interactions;Patients;Peer Review;population health;precision medicine;Principal Investigator;Productivity;programs;Proto-Oncogenes;Publications;radiation response;Regulator Genes;Research;Research Institute;Research Personnel;Resources;RNA;Role;Schools;Scientist;small molecule inhibitor;Source;synergism;targeted treatment;Therapeutic;tool;transcription factor;translational health science;Translational Research;tumor;tumor progression;Tumor Suppressor Proteins;tumorigenesis;Universities;University of Virginia Cancer Center;Virginia;Wages;Work

PROJECT_TITLE: GEN - Project


PHR: Project Narrative Caloric restriction is emerging as a potential antiaging strategy, but diets are difficult to maintain; because pharmacological approaches leveraging the mTORC1 pathway have undesirable side effects, new antiaging therapeutic targets are needed. The transcription factor CEBPB plays a key role in aging phenotypes via changes in the relative levels of two forms of the protein, yet the molecular mechanisms these two isoforms mediate are not fully understood, limiting our ability to precisely perturb this pathway. Here we use high- throughput quantitative imaging to dissect the mechanisms of CEBPB isoforms functions, and deploy synthetic biology approach to monitor and perturb CEBPB function in individual cells.

PI_NAMEs: LIONNET, TIMOTHEE  (contact)

PROGRAM_OFFICER_NAME: WILLIAMS, JOHN

PROJECT_TERMS: Acetylation;Address;Adverse effects;Age;age effect;Aging;anti aging;Binding;Biological Assay;Biology;biophysical model;Biophysical Process;Caloric Restriction;Cell Nucleus;Cells;Chromatin;Complex;Crowding;Custom;design;Diet;Diffusion;Dimensions;dimer;Dimerization;DNA Binding Domain;DNA Library;Dominant-Negative Mutation;Engineering;epigenetic memory;Exhibits;extend lifespan;Fluorescence Resonance Energy Transfer;FRAP1 gene;Genes;Genetic Transcription;gerotherapeutic;Goals;hallmarks of aging;Health;Health Benefit;Heterodimerization;Heterogeneity;Image;Imaging Device;improved;In Vitro;Individual;interest;Knock-out;Libraries;life span;Light;lipid biosynthesis;Measures;Mediating;Mediator;Messenger RNA;Metabolic;Modification;Molecular;Monitor;mTOR inhibition;mTOR Inhibitor;Nuclear;Pathway interactions;pharmacologic;Phase;Phenotype;Phosphorylation;Physical condensation;Play;Post-Translational Protein Processing;PPARG gene;programs;promoter;Protein Isoforms;Proteins;quantitative imaging;Recording of previous events;recruit;Reporter;Reporter Genes;Reporting;restraint;Role;scaffold;senescence;side effect;Signal Transduction;single molecule;small molecule;synthetic biology;System;Technology;Testing;Tissues;tool;Touch sensation;Transcription Coactivator;transcription factor;Transcription Repressor;Transcriptional Activation;Transcriptional Regulation;Translating;Tumorigenicity;Visualization

PROJECT_TITLE: Dissecting CEBPB Function with Synthetic Biology and Imaging

STUDY_SECTION: CMT

STUDY_SECTION_NAME: Cellular and Molecular Technologies Study Section[CMT]


PI_NAMEs: SLINGLUFF, CRAIG LEE (contact)

PROJECT_TERMS: Adoptive Cell Transfers;Advisory Committees;American College of Radiology Imaging Network;base;biobank;Biomedical Engineering;Biostatistics Shared Resource;Bispecific Antibodies;Breast;Cancer Biology;Cancer Burden;Cancer Center;Cancer Center Support Grant;cancer imaging;cancer immunotherapy;cancer therapy;cancer type;Catchment Area;Chest;chronic T-cell leukemia;Clinic;clinical application;clinical development;Clinical Investigator;Clinical Research;Clinical Trials;Clinical Trials Cooperative Group;Collaborations;Colorectal;Combined Modality Therapy;Cyclic GMP;design;Diagnosis;Direct Costs;Disease;Drug Delivery Systems;Early Therapeutic-Clinical Trials Network;Eastern Cooperative Oncology Group;Encapsulated;Engineering;Epigenetic Process;Exposure to;Focused Ultrasound;Funding;Goals;Grant;Image;image guided therapy;immune imaging;Immunologics;Immunomodulators;Immunooncology;Immunotherapeutic agent;Immunotherapy;Incidence;Infrastructure;innovation;Intellectual Property;Interdisciplinary Study;investigator-initiated trial;Investments;Lead;Leadership;Legal patent;Licensing;Lung;Malignant Neoplasms;Melanoma;member;Metastatic malignant neoplasm to brain;Metastatic Prostate Cancer;Molecular;Molecular Genetics;mortality;new technology;new therapeutic target;novel therapeutics;Paper;Patients;Peer Review;Performance;Pharmaceutical Preparations;pre-clinical;preclinical development;Principal Investigator;Productivity;programs;protocol development;Publications;Publishing;recruit;Research;research facility;Research Personnel;response;Schools;Science;Selection for Treatments;small molecule;small molecule therapeutics;Source;success;Technology;Therapeutic;Therapeutic Intervention;therapeutic target;Thoracic Surgical Procedures;Tissues;Toxic effect;translational pipeline;Translational Research;Translational trial;Translations;tumor immunology;tumor microenvironment;University of Virginia Cancer Center;Urothelium;Uterus;Validation;Work;working group

PROJECT_TITLE: CRX - Project


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Foodborne Illness;Genetics;Infectious Diseases

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: NARRATIVE Infection with Toxoplasma gondii is widespread and it poses great risk to individuals should their immune system become compromised. Successful identification of pathogenetic mechanisms utilized by T. gondii to block the immune response may enable future studies designed to improve treatment of toxoplasmosis, including in AIDS patients.

PI_NAMEs: SIBLEY, L. DAVID (contact)

PROGRAM_OFFICER_NAME: JOY, DEIRDRE A

PROJECT_TERMS: Accidents;Acquired Immunodeficiency Syndrome;acute infection;adaptive immunity;Animals;Antibiotics;Area;Attenuated;Back;base;Binding;Cell Death;Cell Nucleus;cell type;Cells;Central Nervous System;Chromatin;Chromatography;chronic infection;Complex;Cryoelectron Microscopy;Cyst;cytokine;differential expression;dimer;domain mapping;effective intervention;Frequencies;Funding;Future;Gene Expression;Genes;Genetic;Genetic Transcription;Growth;Hematopoietic;High Prevalence;Highly Active Antiretroviral Therapy;HIV/AIDS;Host Defense;Human;Immune;Immune response;Immune signaling;Immune system;Immunity;Immunocompromised Host;improved;In Vitro;in vivo;Individual;Infection;Inflammatory;inhibitor;Interferon Type II;Interferon-beta;Interferons;Mediating;Mediator;Molecular;mutant;Natural Immunity;Natural Killer Cells;NuRD complex;Nutrient Depletion;Opportunistic Infections;Parasite Control;Parasites;Pathogenicity;Pathway interactions;Patients;prevent;Process;Production;protein protein interaction;Proteins;recruit;Repressor Proteins;Research Design;Risk;Rupture;Signal Transduction;STAT1 gene;T-Lymphocyte;Testing;Tissue Survival;Tissues;Toxoplasma gondii;Toxoplasmosis;transcription factor;Transcription Repressor;Up-Regulation;Vacuole;virtual;Virulence;X-Ray Crystallography;Zoonoses

PROJECT_TITLE: Molecular Basis of Human Toxoplasmosis

STUDY_SECTION: HCAC

STUDY_SECTION_NAME: HIV Coinfections and HIV Associated Cancers Study Section[HCAC]


NIH_SPENDING_CATS: Behavioral and Social Science;Breast Cancer;Cancer;Clinical Research;Colorectal Cancer;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Lung Cancer;Obesity;Palliative Care;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Tobacco;Tobacco Smoke and Health;Women's Health Research

PI_NAMEs: LI, LI  (contact)

PROJECT_TERMS: acronyms;Address;Advisory Committees;Affect;African American population;age acceleration;Age of Onset;American Cancer Society;anti-cancer research;anxiety symptoms;Area;Automobile Driving;base;Behavior;Behavioral;behavioral economics;behavioral health;Behavioral Medicine;Biological;Breast Cancer Patient;Breast Cancer survivor;Cancer Burden;cancer care;Cancer Center;Cancer Center Support Grant;Cancer Control;cancer epidemiology;Cancer Etiology;cancer health disparity;Cancer Patient;cancer risk;care delivery;care outcomes;Catchment Area;Cognitive Therapy;Collaborations;college;Colon;Colorectal;Colorectal Cancer;community engaged intervention;community engagement;Community Health;Community Outreach;Data;Department of Defense;depressive symptoms;Diet;Direct Costs;Disparity;Dissemination and Implementation;effectiveness testing;Enrollment;epidemiology study;evidence base;Evidence based treatment;Funding;genome wide association study;Genomics;Goals;Grant;Growth;Head;Health;Health Disparities Research;Health equity research;Health Services Research;Health Technology;high risk population;hospice environment;implementation research;Improve Access;improved;improved outcome;Individual;Inflammation;Institution;Intake;Intervention;Intervention Trial;investigator-initiated trial;Investments;Journals;Life Style;lifestyle factors;Low income;Lung;Malignant Neoplasms;medical schools;member;mhealth interventions;Military Personnel;Molecular;Molecular Epidemiology;multidisciplinary;Nicotine Dependence;novel;Obesity;obesity risk;Outcome;Palliative Care;Paper;Participant;Patient-Focused Outcomes;Peer Review;Peer Review Grants;Population;population health;Population Heterogeneity;Positioning Attribute;Prevention;Preventive;Price;Principal Investigator;Productivity;programs;Publications;Publishing;Quality of life;racial disparity;reduce symptoms;Research;Research Personnel;Risk;Risk Assessment;Risk Factors;Risk Reduction;Rural Appalachia;Rural Community;Rural Population;rural underserved;Schools;screening;Services;Side;Sleeplessness;Smoker;smoking cessation;social;Social Environment;Social Processes;Socioeconomic Factors;Source;survivorship;sweetened beverage;synergism;Targeted Research;Testing;Tissues;Tobacco;Tobacco use;Tobacco-Related Carcinoma;tool;Training and Education;Translational Research;United States Preventative Services Task Force;Universities;University of Virginia Cancer Center;Work

PROJECT_TITLE: CPH - Project


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Ovarian Cancer;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases;Women's Health Research

ORG_NAME: H. LEE MOFFITT CANCER CTR & RES INST

PHR: PROJECT NARRATIVE Black women with ovarian cancer have the worst survival of all racial and ethnic groups, and this disparity cannot be entirely explained by differences in access to care or guideline-adherent treatment. We propose to leverage established observational studies to investigate cross-population comparisons of tumor DNA methylation patterns, at both the global and cell-specific level, associated with survival among Black and White women with ovarian cancer. This work will advance the discovery of molecular targets among understudied minorities, informing targeted prevention strategies, clinical decision-making, and the development of personalized therapies to reduce mortality in Black women with ovarian cancer.

PI_NAMEs: PERES, LAUREN COLE (contact)

PROGRAM_OFFICER_NAME: FILIPSKI, KELLY

PROJECT_TERMS: Accounting;African American;Age;B-Lymphocytes;bead chip;Behavior;Black race;black women;cancer epidemiology;Cancer Patient;Cancer Prognosis;cancer survival;CD8B1 gene;cell type;Cells;Characteristics;clinical decision-making;Cox Models;Cytosine;Cytotoxic T-Lymphocytes;Data;Development;Diagnosis;Diagnostic;Diet;differences in access;dimension reduction;disease heterogeneity;Disparate;Disparity;disparity reduction;DNA Methylation;Economics;Education;Endothelial Cells;eosinophil;Epidemiology;epidemiology study;Epithelial Cells;Epithelial ovarian cancer;Ethnic Population;Gene Expression;Genetic;genome-wide;Guanine Nucleotides;Guidelines;Health Services Accessibility;Immune;improved;individualized prevention;innovation;Life Style;Malignant Female Reproductive System Neoplasm;Malignant neoplasm of ovary;Malignant Neoplasms;Measures;Methods;methyl group;Methylation;methylation biomarker;methylation pattern;methylomics;Minority;Minority Groups;Modeling;Molecular;Molecular Target;monocyte;mortality;mortality risk;Natural Killer Cells;neutrophil;North Carolina;novel;Nurses' Health Study;Obesity;Observational Study;Outcome;ovarian neoplasm;Ovarian Serous Adenocarcinoma;personalized medicine;Phenotype;Physical activity;Population;Population Study;Prevention strategy;preventive intervention;Prognosis;Prognostic Factor;Race;racial determinant;racial difference;racial minority population;racial population;Regulator Genes;Regulatory T-Lymphocyte;Reporting;Research;Resources;Serous;Site;Smoking;Smoking Status;social;social culture;Stromal Cells;study population;survival disparity;targeted treatment;Testing;Time;Tissues;tumor;tumor DNA;tumor microenvironment;Underrepresented Minority;Weight;White Women;Woman;Women's mortality;Work

PROJECT_TITLE: Methylomic basis of survival disparities among Black and White women with high-grade serous ovarian cancer

STUDY_SECTION: CHSA

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology A Study Section[CHSA]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cannabidiol Research;Cannabinoid Research;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Endocannabinoid System Research;HIV/AIDS;Infectious Diseases;Natural Products;Neurosciences;Substance Misuse;Therapeutic Cannabinoid Research

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE People with HIV (PWH) use cannabis more than the general population, but its potential beneficial/negative effects on the brain have not been investigated. Here, we will determine whether cannabis has beneficial or negative effects on cognitive functions strongly linked to HIV risk behaviors in PWH compared with healthy participants. We will then utilize an animal model of HIV to determine the directionality of effects of acute and chronic administration, withdrawal from such cannabinoid treatments, as well as effects of antiretroviral therapy using consistent behavioral tests.

PI_NAMEs: MINASSIAN, ARPI  (contact);YOUNG, JARED WILLIAM

PROGRAM_OFFICER_NAME: LIN, YU

PROJECT_TERMS: 2-arachidonylglycerol;Acute;Adult;adverse outcome;Affect;anandamide;Animal Experimentation;Animal Model;Animals;Anti-Inflammatory Agents;Anti-Retroviral Agents;antiretroviral therapy;Area;Attenuated;Behavior;behavior test;Behavioral;Biological;Biological Assay;Biological Markers;Brain;Brain region;Cannabidiol;cannabinoid administration;cannabinoid treatment;Cannabinoids;Cannabis;cannabis administration;Cannabis policy;cannabis withdrawal;Chronic;Clinical Research;Cognition;Cognitive;cognitive control;Cognitive deficits;cognitive function;cognitive process;cognitive testing;comorbidity;Complex;Corpus striatum structure;Decision Making;Desire for food;Disease;Disease Progression;Disinhibition;Dopamine;Dopamine Receptor;dopamine system;Dose;Endocannabinoids;endogenous cannabinoid system;excitotoxicity;Exhibits;exogenous cannabinoid;experimental study;Feedback;follow-up;Formulation;General Population;Harvest;High Prevalence;HIV;HIV risk;HIV-1;Homovanillic Acid;Human;Human immunodeficiency virus test;improved;inattention;Individual;insight;Knowledge;Learning;Lifting;Limbic System;Link;marijuana use;marijuana user;Mediating;Medicine;Modeling;Moods;Motivation;Nausea;neurobiological mechanism;Neurobiology;neurochemistry;Neurocognitive Deficit;neuroprotection;Neurotransmitters;nonhuman primate;Oral;pain relief;Participant;Perception;Persons;Pharmaceutical Preparations;Pharmacology;Placebos;Policies;Population;Prefrontal Cortex;Prevalence;Property;Randomized;Rat Transgene;Rattus;receptor expression;Recommendation;Recreation;remediation;response;Rewards;Risk;Risk Behaviors;Risk Taking;Rodent Model;Role;Severity of illness;Statistical Data Interpretation;substance use;Symptoms;System;Testing;Tetrahydrocannabinol;Therapeutic;therapeutic development;Time Perception;Training;Transgenic Organisms;translational study;transmission process;Viral Load result;Virus;Withdrawal

PROJECT_TITLE: Translational Studies of Cannabis Administration, Cognition, and the Endocannabinoid System in HIV

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


NIH_SPENDING_CATS: Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Rural Health;Tobacco

PI_NAMEs: COHN, WENDY F (contact)

PROJECT_TERMS: acronyms;Address;Advisory Committees;Area;Behavioral;Breast Cancer Detection;Cancer Burden;Cancer Center;Cancer Center Support Grant;Cancer Control;cancer health disparity;cancer prevention;cancer risk;Catchment Area;Cervical Cancer Screening;Collaborations;Colorectal;colorectal cancer screening;Communication;Communities;community advisory board;community based participatory research;community engagement;Community Health;Community Health Systems;Community Outreach;community partnership;Coupled;Data;Data Reporting;Data Sources;Dedications;Development;Disparity;Doctor of Philosophy;Education and Outreach;Evaluation;evidence base;Evidence based intervention;Faculty;Fostering;Foundations;Goals;Growth;health equity;Health equity research;Health system;Healthcare Systems;higher education;Human Papillomavirus;Immunization;improved;Intervention;Investments;Knowledge;Leadership;Lung;Malignant Neoplasms;member;mortality;multiple data sources;Needs Assessment;outreach;Policies;Population;preference;Prevention;Process;programs;public policy on tobacco;Research;Research Personnel;Risk Factors;rural disparities;rural dwellers;Science;Screening for cancer;SEER Program;service uptake;Services;Strategic Planning;success;Surveys;System;Tobacco;tobacco-free;Translational Research;treatment program;tumor registry;University of Virginia Cancer Center;Virginia;Work

PROJECT_TITLE: Community Outreach & Engagement


NIH_SPENDING_CATS: Autism;Brain Disorders;Clinical Research;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PHR: PROJECT NARRATIVE  In this project, we will study Pitt-Hopkins Syndrome, a childhood genetic disorder characterized by severe neurological symptoms, including intellectual disability, motor delay, absence of speech, constipation, and autistic behaviors. Currently, there are no specific treatment or cure for this condition, in part because little is known about how the brains of affected children are impaired. We will use cells derived from Pitt-Hopkins Syndrome patients and cultivated in vitro to understand what is altered in neurons and other cell types in the brain and to test strategies to correct the mutated gene involved in the disease and ameliorate the impaired characteristics and symptoms.

PI_NAMEs: MUOTRI, ALYSSON R. (contact)

PROGRAM_OFFICER_NAME: PANCHISION, DAVID M

PROJECT_TERMS: Affect;Anatomy;Animal Model;Architecture;autism spectrum disorder;autistic behaviour;autistic children;Back;Biochemical Process;Brain;Cell Line;Cell model;cell type;Cells;Cerebrum;Characteristics;Child;Childhood;ChIP-seq;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;Communities;Constipation;Data;de novo mutation;Defect;Development;Disease;Down-Regulation;Drug Screening;electrical property;Electrophysiology (science);Epigenetic Process;Exhibits;experimental study;Face;Family;Functional disorder;Future;gastrointestinal;gene therapy;Genes;Genetic;genetic approach;Genetic Diseases;Genetic Predisposition to Disease;Genome;Goals;Healthcare Systems;Human;human model;Impairment;In Vitro;in vitro Model;Individual;Intellectual functioning disability;Investigation;Knowledge;Lead;Link;Mediating;Modeling;Molecular;Morphology;Motor;mouse model;Mutate;Mutation;mutation correction;Nature;nerve stem cell;Nervous System;neural;neurodevelopment;Neurologic Symptoms;Neuronal Differentiation;Neurons;neuropathology;Organoids;Outcome;overexpression;Parents;Pathologic;Pathway interactions;patient derived induced pluripotent stem cells;Patients;pharmacologic;Phenotype;Physiological;Pitt-Hopkins syndrome;prevent;progenitor;Proliferating;Property;repetitive behavior;Rodent;senescence;severe intellectual disability;single-cell RNA sequencing;Speech;stem cell proliferation;Structure;Symptoms;synaptogenesis;TCF4 haploinsufficiency;TCF7L2 gene;Testing;therapeutic target;Tissues;transcription factor;transcriptome sequencing;WNT Signaling Pathway

PROJECT_TITLE: Investigation of Pitt-Hopkins Syndrome pathophysiology using a human model


PI_NAMEs: LOUGHRAN, THOMAS P. (contact)

PROJECT_TERMS: acronyms;Address;Area;Award;Basic Science;Cancer Biology;Cancer Center;Cancer Center Support Grant;Cancer Control;cancer initiation;Catchment Area;Clinical Research;Clinical Trials;Collaborations;Colorectal;community engagement;Community Outreach;Development;Epigenetic Process;Faculty;Faculty Recruitment;Funding;Funding Agency;Goals;high risk;innovation;Institution;Investments;Leadership;Lung;Malignant Neoplasms;Measures;member;Molecular Genetics;Nanotechnology;Obesity;Outcome;Paper;Peer Review Grants;Persons;Pilot Projects;population health;Population Research;precision medicine;programs;Publications;recruit;Request for Applications;Research;Research Project Grants;Risk Factors;Science;sound;Source;Stimulus;Strategic Planning;success;Therapeutic;Tobacco use;Translational Research;Universities;University of Virginia Cancer Center

PROJECT_TITLE: Development Funds


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

NIH_SPENDING_CATS: Hearing Loss;Neurosciences

ORG_CITY: ROCHESTER

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: For the cochlea to function properly in the adult, multiple cell types must mature properly into specific cell types, including hair cells, supporting cells and neurons. This proposal seeks to define the molecular signaling pathways necessary for the final steps of cell maturation in the cochlea, steps that are currently not well understood. Deciphering these processes is critical for understanding hearing loss and for developing therapeutic interventions.

PI_NAMEs: KIERNAN, AMY  (contact)

PROJECT_TERMS: Adopted;Adult;Alleles;Auditory Brainstem Responses;auditory neuropathy;Binding;Cell Maturation;cell type;Cells;Cochlea;Complex;Data;deafness;Defect;Development;Down-Regulation;Ear;Embryo;Ensure;Epithelium;experimental study;Functional disorder;Future;Gene Expression Regulation;Genes;Hair Cells;Hearing;hearing impairment;Histologic;Human;Impairment;inducible Cre;Inner Hair Cells;Labyrinth;Lateral;Ligands;Maintenance;Mammals;Mediating;Membrane;Molecular;mosaic;mouse model;mutant;Natural regeneration;Neonatal;Neurons;notch protein;Notch Signaling Pathway;novel;Organ of Corti;otoacoustic emission;Pathology;Pathway interactions;Pattern;Play;postnatal;prevent;Process;receptor;Receptor Cell;regenerative therapy;Role;Sensory;Signal Pathway;Signal Transduction;Supporting Cell;System;Testing;Therapeutic Intervention;transcriptome sequencing;transdifferentiation;Up-Regulation;Vestibular Diseases

PROJECT_TITLE: Notch Signaling during Organ of Corti Maturation and Maintenance


PI_NAMEs: FOX, JAY WILLIAM (contact)

PROJECT_TERMS: acronyms;Address;Advisory Committees;Animal Disease Models;anti-cancer research;Basic Science;biobank;Bioinformatics;Biostatistics Shared Resource;Cancer Center;Cancer Center Support Grant;Cancer Control;cancer research center director;Cancer Research Project;cancer therapy;Clinical Research;community center;cost effective;Data;DNA sequencing;Education;Elements;Ensure;Equipment;Flow Cytometry;Funding;Future;Goals;Immune response;Immunologics;improved;incomplete Freund's adjuvant;instrumentation;Malignant Neoplasms;medical schools;meetings;member;metabolomics;Microscopy;Mission;Molecular;Monitor;Names;operation;Outcome;population health;Population Sciences;Positioning Attribute;Procedures;Process;programs;Proteomics;Protocols documentation;Publications;Recommendation;Reproducibility;Research;research facility;Research Personnel;Resource Sharing;response;service delivery;Services;Site;Strategic Planning;Structure;Suggestion;Technology;Tissues;training opportunity;transcriptome sequencing;Translational Research;Trust;United States National Institutes of Health;University of Virginia Cancer Center;Vaccines;Virginia;Work

PROJECT_TITLE: Shared Resource Management


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;HIV/AIDS;Infectious Diseases;Mental Health;Neurosciences;Pediatric;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: PHILADELPHIA

ORG_DEPT: PATHOLOGY

PHR: Narrative: Despite antiretroviral therapy, HIV-infected adolescents have persistent cognitive and behavioral deficits. Given the ongoing development of white matter and myelin at this age we aim to examine the effects of HIV infection and antiretroviral drugs on development of white matter in the brain in adolescents.

PI_NAMEs: GRINSPAN, JUDITH B;JORDAN-SCIUTTO, KELLY L (contact)

PROGRAM_OFFICER_NAME: RAO, VASUDEV RAMACHANDRA

PROJECT_TERMS: Adolescence;Adolescent;Adolescent and Young Adult;Adult;Age;Age of Onset;age related;age related changes;Anisotropy;Anti-Retroviral Agents;antiretroviral therapy;Behavioral;behavioral impairment;biological adaptation to stress;Brain;Caring;CD4 Positive T Lymphocytes;Cell Count;Cell Differentiation process;Central Nervous System;Clinical;Cognitive;cohort;Data;density;Development;differentiation in vitro;Diffusion Magnetic Resonance Imaging;emtricitabine;Fumarates;Functional disorder;Gene Expression;Genes;gray matter;HIV;HIV Infections;HIV-1;HIV-associated neurocognitive disorder;HIV-infected adolescents;Human;Image;Impaired cognition;In Vitro;in vitro Model;in vivo;indexing;Infection;Knowledge;Laboratories;Learning;Lesion;Lipids;Lysosomes;Macrophage;Magnetic Resonance Imaging;Measures;Mediating;meetings;Memory;morphometry;motor impairment;Myelin;Myelin Proteins;Myelin Sheath;myelination;Neurites;neuroimaging marker;neuroinflammation;non-invasive monitor;Nucleosides;oligodendrocyte progenitor;Oligodendroglia;Pathologic;Pathology;Pathway interactions;Patients;Pattern;Pharmaceutical Preparations;pre-exposure prophylaxis;precursor cell;prevent;protein expression;Rat Transgene;Rattus;remyelination;Reverse Transcriptase Inhibitors;Rodent Model;Role;Stress;Structure;success;Synaptic plasticity;synaptic pruning;Tenofovir;Therapeutic Effect;Thick;Time;Transcript;transcriptome;Treatment-related toxicity;United States;Up-Regulation;Viremia;Virus;Virus Replication;white matter;young adult

PROJECT_TITLE: Effects of HIV and ART on myelination in the adolescent

STUDY_SECTION: HVCD

STUDY_SECTION_NAME: HIV Molecular Virology, Cell Biology, and Drug Development Study Section[HVCD]


PROJECT_TERMS: acronyms;Advisory Committees;Animal Disease Models;anti-cancer research;Area;Basic Science;Cancer Biology;Cancer Center;Cancer Center Support Grant;Cancer Control;Cancer health equity;career development;Catchment Area;Chemistry;Clinical Investigator;Clinical Research;Clinical Sciences;Clinical Trials;Collaborations;Communities;community based participatory research;community engagement;Community Outreach;Data Science;Development;Disclosure;drug discovery;Education;Ensure;Epigenetic Process;Evaluation;Faculty Recruitment;Feedback;Funding;Future;Genomics;Goals;Immunologics;improved;Individual;Infrastructure;Intervention Trial;Large granular lymphocyte;Leadership;Legal patent;Licensing;Malignant Neoplasms;medical schools;meetings;member;Mentorship;Mission;Molecular;Molecular Genetics;Monitor;Oncology;Outcome;Persons;Population;population health;Population Research;Population Sciences;Positioning Attribute;Process;programs;Recommendation;recruit;Research;Research Personnel;Resource Sharing;Schools;Science;Scientist;Source;Strategic Planning;Strategic vision;Tobacco;Training;Training Activity;Training and Education;translational pipeline;Translational Research;undergraduate research experience;University of Virginia Cancer Center;Work

PROJECT_TITLE: Leadership, Planning & Evaluation


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative Yerkes National Primate Research Center (YNPRC) maintains a colony of Indian origin specific pathogen free (SPF), pedigreed and genetically characterized rhesus macaques to supply animals for the large portfolio of AIDS research conducted at the Center. YNPRC had over $25 million in grant funding for nonhuman primate (NHP) AIDS research during FY20 in which was a 20% increase in funding since FY2013 with approximately 39% of rhesus macaques allocated to external AIDS investigators. The SPF colony at the YNPRC Field Station supports this colony with expert leadership and management to maintain and grow this colony of animals in support of AIDS research.

PI_NAMEs: COHEN, JOYCE KIMBERLY (contact)

PROGRAM_OFFICER_NAME: SUI, YONGJUN

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Alleles;Animal Model;animal resource;Animals;antiretroviral therapy;Breeding;Diagnostic tests;Disease;effective therapy;Ensure;Fees;Foundations;Funding;Genetic;genetic information;genetic pedigree;germ free condition;Grant;Growth;Health;HIV;HIV Infections;HIV/AIDS;Income;Infection prevention;Institution;Leadership;Life Expectancy;Macaca;Macaca mulatta;Maintenance;MHC Class I Genes;Modeling;Molecular;nonhuman primate;Persons;pre-clinical;preclinical study;prevent;Primates;Process;Production;programs;Recording of previous events;Request for Applications;Research;Research Personnel;Research Project Grants;Resource Development;Resources;Scientist;Serology;success;Techniques;Testing;therapy development;United States;United States National Institutes of Health;Viral;virus testing

PROJECT_TITLE: Maintenance of the SPF Breeding Colonies at Yerkes National Primate Research Center

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIB-J(52)]


ED_INST_TYPE: OTHER SPECIALIZED SCHOOLS

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: Princeton

ORG_DEPT: MISCELLANEOUS

ORG_NAME: PRINCETON UNIVERSITY

ORG_STATE: NJ

PHR: PROJECT NARRATIVE Phage VP882 is the first discovered phage capable of detecting bacterial host-produced quorum-sensing communication molecules, called autoinducers. Autoinducer detection by phage VP882 drives its lysogeny to lytic transition, resulting in host lysis. The proposed work will combine genetic, biochemical, and structural approaches to provide a mechanistic understanding of cross-domain communication between vibriophage VP882 and its host, the global pathogen Vibrio cholerae; it will also lay the necessary foundation for engineering phages responsive to particular sensory cues for phage therapy development.

PI_NAMEs: BEGGS, GRACE  (contact)

PROGRAM_OFFICER_NAME: RIGAS, MARC

PROJECT_TERMS: arms race;Bacteria;bacterial community;bacterial genetics;Bacteriophages;Behavior;Binding;Biochemical;Cells;Chemicals;Chromosomes;combat;Communication;Communities;Complex;Crystallization;Crystallography;Cues;Cytolysis;Detection;Development;DNA Damage;Engineering;follow-up;Foundations;Genes;Genetic;Genetic Screening;Genetic study;Goals;Habitats;human disease;imaging study;in vivo;Individual;Industry;Infection;insight;Institution;Intercept;Investigation;Label;Laboratories;Learning Skill;Length;Life Style;Light;Lysogeny;Lytic;Lytic Phase;Maintenance;Mass Spectrum Analysis;Mediating;member;Methods;Molecular;Monitor;Mutagenesis;offspring;Outcome;overexpression;pandemic disease;pathogen;Pathway interactions;Phage Receptors;Physiological;Positioning Attribute;post-doctoral training;Process;Production;programs;promoter;Protein Biochemistry;Proteins;quorum sensing;Recombinants;Reporter;Repression;Repressor Proteins;Research;Resolution;response;Role;Sensory;Signal Transduction;skills;Stress;structural biology;Structure;therapy development;Vibrio cholerae;Vibrio cholerae infection;Virus;Work

PROJECT_TITLE: Quorum-sensing mediated communication between pandemic Vibrio cholerae and phage VP882

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F08-M(20)L]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Genetics;HIV/AIDS;Infectious Diseases;Prevention

PHR: NARRATIVE Not required for this component, per RFA.

PROJECT_TERMS: Animals;Behavioral;Breeding;Caring;cohort;dashboard;Data;Data Set;Databases;Eligibility Determination;Employee;Ensure;Female;Funding;Future;Genetic;genetic pedigree;Genotype;Growth;Health;Herpesvirus 1;high standard;HIV/AIDS;Human Resources;improved;Individual;Macaca mulatta;Maintenance;male;Measures;Performance;Persons;Population;post-COVID-19;Prevention;Primates;Production;public health relevance;Recording of previous events;Reporting;reproductive;Research;Research Personnel;Research Subjects;Resource Informatics;Resources;Risk Reduction;Running;Safety;social;Social Network;social skills;Socialization;success;System;United States National Institutes of Health;Virus;web-accessible;Work

PROJECT_TITLE: Husbandry and Management Core-Maintenance of the SPF Breeding Colonies at Yerkes National Primate Research Center

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIB-J]


NIH_SPENDING_CATS: Aging;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Patient Safety

PI_NAMEs: DALAL, PARCHAYI  (contact)

PROJECT_TERMS: biobank;Budgets;Cancer Center;Cancer Center Support Grant;cancer clinical trial;cancer site;Catchment Area;Clinical Cancer Center;Clinical Data;clinical infrastructure;Clinical Oncology;Clinical Protocols;Clinical Research;Clinical Trials;Complex;Data;data management;Development;Disease;Education;Elderly;Elements;Enrollment;Grant;Growth;Health system;human old age (65+);Individual;Industrialization;Infrastructure;Institutional Review Boards;Intervention;Intervention Studies;Intervention Trial;Investigational Drugs;investigator-initiated trial;life span;Maintenance;Malignant Neoplasms;Minority;Monitor;Newly Diagnosed;Nurses;operation;Patients;Pharmaceutical Services;Process;programs;protocol development;Protocols documentation;quality assurance;recruit;Research;Research Activity;research facility;Research Infrastructure;Research Personnel;Rural Community;Safety;Services;Stress;Therapeutic Trials;Time;Tissues;Training;treatment trial;trial design;University of Virginia Cancer Center;Woman;Work;Writing

PROJECT_TITLE: Clinical Protocol & Data Management


NIH_SPENDING_CATS: Childhood Obesity;Diabetes;Maternal Health;Nutrition;Obesity;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Women's Health Research

ORG_CITY: Nashville

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: Project Narrative Clinical indications for metformin have expanded from the treatment of Type 2 Diabetes to use as a second line therapeutic to insulin in pregnant women with gestational diabetes, polycystic ovarian syndrome, and preeclampsia. Data suggest that metformin crosses the placenta and equilibrates in fetal and maternal circulation, elevating concerns of unintended fetal harm. This proposal aims to elucidate the effect that developmental exposure to metformin and maternal overnutrition has on beta-cell function and mitochondrial health in the pancreatic islets of offspring.

PI_NAMEs: CARROLL, DARIAN THOMAS (contact)

PROGRAM_OFFICER_NAME: RIVERS, ROBERT C

PROJECT_TERMS: 1 year old;Adenosine Monophosphate;Adipose tissue;Adult;Alpha Cell;Architecture;Attenuated;Automobile Driving;Beta Cell;Biological Assay;Birth Weight;Body mass index;Cell Count;Cell Fraction;cell growth;Cell Physiology;Cell Proliferation;Cell Respiration;Cells;Circulation;Classification;Clinical;clinical practice;Collaborations;Consumption;Data;density;detection of nutrient;Development;Disease;Dose;Drug Prescriptions;early childhood;Endocrine;endocrine pancreas development;Environment;epigenetic regulation;Exhibits;experience;Exposure to;Failure;Female;Female of child bearing age;fetal;Fetal Growth;Fetal Growth Retardation;fetal programming;Fetus;Gene Expression;Genus Hippocampus;Gestational Diabetes;Glucose;glucose uptake;Goals;Growth;Health;Human;Individual;Insulin;insulin granule;insulin secretion;Intake;interest;islet;Islets of Langerhans;Knowledge;Life;Lighting;Link;Liver;Macaca mulatta;Maintenance;maternal obesity;Metabolic;Metabolic Diseases;Metabolism;Metformin;Microscopy;Mitochondria;Mitochondrial Electron Transport Complex I;Modeling;Morphology;mother nutrition;Mothers;Muscle;NADH dehydrogenase (ubiquinone);next generation;Non-Insulin-Dependent Diabetes Mellitus;nonhuman primate;nutrient metabolism;Obesity;offspring;Outcome;Overnutrition;Overweight;Pancreas;pancreas development;Pathway interactions;Phenotype;Phosphotransferases;Physiological;Placenta;Polycystic Ovary Syndrome;post pregnancy;Pre-Eclampsia;Pregnancy;Pregnant Women;prenatal exposure;Prevalence;Production;Proliferating;Protein Synthesis Inhibition;Regulation;Resolution;Respiration;response;Risk;single nucleus RNA-sequencing;Structure;Structure of beta Cell of islet;Therapeutic;Time;Tissues;Transmission Electron Microscopy;United States;western diet;Woman

PROJECT_TITLE: The Influence of Developmental Exposure to Maternal Overnutrition and Metformin on Offspring Mitochondrial Health and Beta Cell Function


NIH_SPENDING_CATS: Behavioral and Social Science;Chronic Obstructive Pulmonary Disease;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Physical Rehabilitation;Primary Health Care;Rehabilitation;Social Determinants of Health

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative Chronic obstructive pulmonary disease (COPD) is a leading cause of death in the U.S. with few interventions that effectively modify disease course. Pulmonary rehabilitation is one notable exception; yet, this service is grossly underutilized, especially within low resourced healthcare settings that provide majority of the care for socially vulnerable populations with COPD. The proposed study will test an innovate low-resource, community- based pulmonary rehabilitation program with social supports for patients with symptomatic COPD.

PI_NAMEs: THAKUR, NEETA  (contact)

PROGRAM_OFFICER_NAME: LU, QING

PROJECT_TERMS: Address;Adherence;Adoption;Advocate;Affect;arm;beneficiary;Body Weight;Caring;Cause of Death;Chronic Obstructive Pulmonary Disease;Clinic;Clinical;Clinical Trials;Communities;contextual factors;Control Groups;cost;County;Coupled;design;Disease;Disease Outcome;economic disparity;Educational process of instructing;effective intervention;effectiveness evaluation;effectiveness testing;effectiveness/implementation design;Elements;Enrollment;Environment;Equipment;evidence base;Evidence based intervention;Evidence based program;Exercise;exercise training;experience;Face;food insecurity;functional decline;functional improvement;functional outcomes;Geographic Locations;Geography;Goals;Health;Health Benefit;health care settings;Health Resources;Healthcare Systems;heart rate monitor;high risk;Hospitalization;housing instability;implementation barriers;implementation evaluation;implementation intervention;improved;improved outcome;Individual;innovation;Intervention;intervention delivery;intervention effect;Interview;Leadership;Life;Link;low health literacy;Low income;Maintenance;Medicare;Methods;Mission;Monitor;Morbidity - disease rate;neighborhood disadvantage;Neighborhoods;older patient;Outcome;Oxygen;Participant;Pathway interactions;patient engagement;patient population;patient-level barriers;Patients;peer;pilot trial;Population;portability;post intervention;preservation;Primary Care;primary outcome;Process;programs;pulmonary rehabilitation;Qualitative Methods;Quality of life;Randomized;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Rehabilitation Centers;Rehabilitation therapy;resistance exercise;Resources;Risk Reduction;safety net;San Francisco;screening;secondary outcome;Self Management;Services;Site;social;Social Environment;Social support;social vulnerability;stressor;Structure;Symptom Burden;symptomatic improvement;Symptoms;system-level barriers;Testing;three-arm trial;treatment as usual;Underinsured;Vulnerable Populations;Waiting Lists;Walking

PROJECT_TITLE: Rehabilitation in Safety-Net Environments (RISE) for COPD

STUDY_SECTION: SIHH

STUDY_SECTION_NAME: Science of Implementation in Health and Healthcare Study Section[SIHH]


PI_NAMEs: VANDERFORD, THOMAS HOWERTON (contact)

PROJECT_TERMS: 2019-nCoV;Accidents;Acquired Immunodeficiency Syndrome;animal resource;Animals;Antibodies;Antigens;Biological Assay;Breeding;California;cost;cost effective;COVID-19 screening;COVID-19 surveillance;COVID-19 testing;Dependovirus;Detection;Diagnosis;Diagnostic;diagnostic assay;diagnostic screening;Diagnostic Services;Diagnostic tests;DNA;Ensure;Exposure to;Fee-for-Service Plans;Flavivirus;Freezing;Funding;germ free condition;Health;Herpesvirus 1;HIV vaccine;Human;Immunoassay;Infection;Laboratories;Macaca;Macaca mulatta;Maintenance;Methodology;Molecular;NIH Program Announcements;nonhuman primate;pathogen;Pathogenesis;Peripheral Blood Mononuclear Cell;Polymerase Chain Reaction;prevent;Primates;programs;Protocols documentation;Recommendation;Reporting;Research;Research Infrastructure;Research Personnel;Retroviridae Infections;Risk;Running;Sampling;SARS-CoV-2 infection;screening;Serology;SIV;Specificity;success;Swab;Testing;Time;Tissues;Type D Retrovirus;United States National Institutes of Health;Viral;Viral Antigens;viral detection;Viral Genome;virology;Virus;Virus Integration;virus testing;Western Blotting

PROJECT_TITLE: Viral Testing Core-Maintenance of the SPF Breeding Colonies at Yerkes National Primate Research Center


NIH_SPENDING_CATS: Cancer;Patient Safety

PI_NAMEs: GENTZLER, RYAN  (contact)

PROJECT_TERMS: acronyms;Adherence;Adverse event;Agreement;Amendment;authority;Cancer Center Support Grant;cancer initiation;cancer research center director;Charge;Clinical Research;Clinical Trials;Data;data management;design;Development;Disease;Doctor of Philosophy;Ensure;Goals;Guidelines;Human;human subject;implementation process;Industry;Institution;Institutional Review Boards;Malignant Neoplasms;Mediating;meetings;Monitor;Monitoring Clinical Trials;National Clinical Trials Network;Patients;Peer Review;Pharmacy facility;Play;Principal Investigator;Protocols documentation;Research;Research Personnel;Research Priority;research study;Review Committee;Role;Safety;Serious Adverse Event;sound;System;United States National Institutes of Health;Universities;University of Virginia Cancer Center;Virginia;Voting

PROJECT_TITLE: Protocol Review & Monitoring System


NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Prevention

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Narrative The goal of this proposal is to increase our understanding of the role of immune cells in the early adaptation process of cardiac stress. The results of these studies will provide a platform to develop therapeutic strategies to enhance the adaptive remodeling of the heart, while postponing or even preventing heart failure. Cardiovascular disease and heart failure are leading causes of death worldwide, and interventions that can transform pathological into physiological remodeling will have a major impact on disease progression after cardiac injury.

PI_NAMEs: REVELO, XAVIER ;VAN BERLO, JOHANNES (JOP)  (contact)

PROGRAM_OFFICER_NAME: POIZAT, CORALIE ISABELLE

PROJECT_TERMS: Adult;angiogenesis;Antibodies;B-Cell Activation;B-Lymphocytes;Blood Vessels;Cardiac;Cardiac Myocytes;Cardiovascular Diseases;Cause of Death;Cell Culture Techniques;Cells;Coculture Techniques;coping;Cytometry;Data;Development;Disease Progression;Endothelial Cells;Exercise;experimental study;gene regulatory network;Genetic;Goals;Growth;Health;Heart;Heart failure;heart function;Heart Hypertrophy;Heart Injuries;Hospitalization;Hypertension;Hypertrophy;Image;Immune;in vivo;Injury;innovation;innovative technologies;insight;Intervention;Label;Macrophage;Macrophage Activation;Mediating;monocyte;mouse model;Myocardial;Myocardium;Natural regeneration;novel therapeutics;Pathologic;Pathway interactions;Phase;Physiological;Play;Pregnancy;pressure;prevent;Prevention;Process;Production;Proliferating;recruit;Research;response;Role;Signal Pathway;single-cell RNA sequencing;Societies;Stress;Survival Rate;T-Lymphocyte;Techniques;Therapeutic;Tissues;treatment strategy;United States;Work

PROJECT_TITLE: Immune Mechanisms Regulating Cardiac Remodeling

STUDY_SECTION: CCHF

STUDY_SECTION_NAME: Cardiac Contractility, Hypertrophy, and Failure Study Section[CCHF]


NIH_SPENDING_CATS: Bioengineering;Cancer

PHR: Project Narrative: Per PAR-20-043, Project Narrative is not completed.

PI_NAMEs: HAO, SIJIE  (contact)

PROJECT_TERMS: acronyms;Advanced Development;anti-cancer research;Biological Process;cancer cell;Cancer Center Support Grant;cancer therapy;Cells;Collaborations;Communities;Conceptions;Country;Cryoelectron Microscopy;Data;data acquisition;Data Analyses;design;Development;Education;education resources;Educational workshop;Electrons;Ensure;Equipment;experimental study;Fluorescence;Fostering;Foundations;Funding;Goals;Human;Human Resources;Image;Image Analysis;image processing;imaging capabilities;Imaging Device;Imaging technology;improved;Individual;insight;Institution;instrument;instrumentation;Learning;Light;Malignant Neoplasms;medical schools;meetings;member;Microscopy;NCI Center for Cancer Research;operation;Pathogenicity;Performance;performance tests;Preparation;Protocols documentation;quantitative imaging;Reproducibility;Research;research and development;Research Personnel;Resource Sharing;Resources;Rotation;Sampling;Secure;Services;symposium;Technology;theories;tool;Training;Training and Education;United States National Institutes of Health;University of Virginia Cancer Center;Vendor;Visualization;webinar;Work

PROJECT_TITLE: AMF - SR Component