NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Cervical Cancer;Clinical Research;Dissemination and Implementation Research;Health Services;Infectious Diseases;Prevention;Primary Health Care;Sexually Transmitted Infections;Women's Health Research

ORG_CITY: BURLINGTON

ORG_NAME: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE

ORG_STATE: VT

PHR: PROJECT NARRATIVE Reducing the global disparities in cervical cancer – which is an entirely preventable disease – requires scale- up of available preventive interventions such as HPV vaccination and screening. Biomedical research has successfully developed technologies required to meet this demand; now we must complement this success with development of processes and tools to help countries adopt and integrate these prevention strategies into their routine public health services. Our project builds on a successful application of stakeholder-engaged systems thinking by developing the ASSIST (Adaptation, ScaleUp, Sustainability: Implementation by Systems Thinking) implementation strategy and toolkit, designed to enable countries to adapt and plan for HPV-based screening according to their own context, resources, preferences, and values.

PI_NAMEs: PAZ-SOLDAN, VALERIE ANDREA;TRACY, J. KATHLEEN (contact)

PROGRAM_OFFICER_NAME: DORIA-ROSE, PAUL P

PROJECT_TERMS: Acceleration;Accounting;Adopted;Adoption;Algorithms;Behavior;behavior change;behavior change wheel;Biomedical Research;burden of illness;Cancer Etiology;Case Study;cervical cancer prevention;Cervical Cancer Screening;comparative;Complement;Complex;Country;Data;Data Sources;design;Development;Disease;Disparity;dissemination science;Economics;effectiveness evaluation;Elements;Ethical Issues;Evaluation;evidence base;Goals;Guidelines;Health;Health Sciences;Health system;Health Technology;HPV screening;Human Papilloma Virus Vaccination;Human Papillomavirus;implementation framework;implementation research;implementation science;implementation strategy;improved;Incidence;Individual;Inequity;Interruption;Intervention;Interview;Link;low and middle-income countries;Malignant neoplasm of cervix uteri;Mediator;meetings;Methods;molecular diagnostics;Motivation;Parents;Peruvian;Phase;Policies;preference;Prevention strategy;preventive intervention;Process;programs;Public Health;Qualitative Methods;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Research;Research Activity;Research Methodology;Resources;scale up;screening;screening program;Series;social;success;surveillance data;System;Technology;Technology Assessment;Testing;theories;therapy design;Thinking;Time;tool;Translating;treatment program;trend;United States Public Health Service;Woman;Women's mortality;Work

PROJECT_TITLE: Translating Molecular Diagnostics for Cervical Cancer Prevention into Practice

STUDY_SECTION: SIHH

STUDY_SECTION_NAME: Science of Implementation in Health and Healthcare Study Section[SIHH]


ADMINISTERING_IC: NS

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Aging;Biotechnology;Brain Disorders;Genetics;Human Genome;Neurodegenerative;Neurosciences;Parkinson's Disease

ORG_CITY: MIAMI

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_FIPS: US

ORG_NAME: FLORIDA INTERNATIONAL UNIVERSITY

ORG_STATE: FL

PHR: The proposed study will examine how TMEM230 mutation cosegregating with late-onset Parkinson’s disease leads to degeneration of dopaminergic neurons in animal models and thus will determine the nature of TMEM230 mutation on neurons at a systemic level, providing a critical input on the mechanism of Parkinson’s disease.

PI_NAMEs: XIA, XUGANG  (contact);ZHOU, HONGXIA

PROGRAM_OFFICER_NAME: SARRAF, SHIREEN AKHAVAN

PROJECT_TERMS: 20p;Affect;Aging;Animal Model;Bioinformatics;biomarker identification;C-terminal;Cell Culture Techniques;Cell Death;Cell Physiology;Chromosomes;cohort;Development;Diagnosis;Disease;disease phenotype;Disease Progression;DNA Sequence Alteration;DNA Sequence Rearrangement;Dopamine;dopaminergic neuron;effective therapy;Elderly;exome sequencing;Family;functional loss;gene discovery;Genes;Genetic;genetic linkage analysis;Genetic Polymorphism;genetic variant;genome sequencing;genome-wide linkage;Human;Immunoprecipitation;Impairment;invention;Knock-in;Knock-out;Link;Midbrain structure;Molecular;Molecular Chaperones;Monitor;mutant;Mutation;Nature;Nerve Degeneration;Neurodegenerative Disorders;neuron loss;neuronal survival;Neurons;neuroprotection;next generation sequencing;novel;Nucleotides;overexpression;Paper;Parkinson Disease;Pathogenesis;Pathogenicity;Pathologic;Pathway interactions;Patients;Penetrance;Phenotype;Physiological;Pilot Projects;Point Mutation;Process;promoter;Proteins;Proteomics;Rat Transgene;Rattus;Reporting;Research;reuptake;Role;segregation;targeted sequencing;therapeutic effectiveness;tool;Transgenic Organisms;Variant;whole genome

PROJECT_TITLE: TMEM230 and Neurodegeneration in Parkinson's Disease

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Breast Cancer;Cancer;Genetic Testing;Genetics;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Women's Health Research

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE I have led many of the genetic studies of breast cancer predisposition with the goal of providing improved hereditary cancer genetic testing and personalized risk assessment for the population. Here I outline my vision for advancing the field of breast cancer predisposition through a series of translational studies that will result in improved risk estimation and determination of the value of directed therapy for many of these individuals. These studies represent a significant step towards eliminating many of the issues faced by patients receiving clinical genetic testing for breast cancer.

PI_NAMEs: COUCH, FERGUS JOSEPH (contact)

PROGRAM_OFFICER_NAME: NELSON, STEFANIE A

PROJECT_TERMS: Address;Adjuvant;African American;African American population;Age;age related;Alleles;ATM gene;Award;BARD1 gene;BRCA1 gene;BRCA1 Mutation;BRCA2 gene;BRCA2 Mutation;Breast Cancer Patient;Breast Cancer Risk Factor;Breast Cancer therapy;cancer clinical trial;cancer predisposition;cancer risk;CDH1 gene;CHEK2 gene;Clinical;clinical application;clinically relevant;Cohort Studies;Collaborations;Data;Decision Making;Disease;Estrogen receptor negative;Estrogen receptor positive;Exhibits;Family;Family history of;Gene Mutation;Genes;Genetic;genetic panel test;Genetic Predisposition to Disease;Genetic study;genetic testing;genetic variant;Goals;Guidelines;Hereditary Malignant Neoplasm;Heritability;improved;Individual;Inherited;lifetime risk;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Neoplasms;Medical;Medical Genetics;Metastatic breast cancer;Minority Groups;Modeling;Mutate;mutation carrier;Neoadjuvant Therapy;NF1 gene;novel;Outcome;PALB2 gene;Pathogenicity;Patients;Penetrance;Population;PTEN gene;RAD51C gene;rare variant;Risk;Risk Assessment;Risk Estimate;Risk Management;risk variant;Series;Susceptibility Gene;targeted treatment;Test Result;TP53 gene;translational study;treatment response;triple-negative invasive breast carcinoma;Variant;variant of unknown significance;Vision

PROJECT_TITLE: Resolving the cancer relevance of predisposition gene mutations


ADMINISTERING_IC: LM

ED_INST_TYPE: OTHER SPECIALIZED SCHOOLS

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: American Indian or Alaska Native;Bioengineering;Clinical Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Rural Health

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE This community-engaged study seeks to improve research results dissemination for American Indian and Alaska Native communities through co-designing collaborative technology systems. American Indian & Alaska Native people have experienced a history of distrustful health research such as being exposed to procedures without informed consent and having research results disseminated without community input or approval making community research collaboration critical from project conceptualization to results dissemination. Results from this study will inform future development of culturally responsive collaborative technology systems for health research results dissemination for use with marginalized communities.

PI_NAMEs: DIRKS, LISA GRACE (contact)

PROGRAM_OFFICER_NAME: YOON, SUNG SUG

PROJECT_TERMS: acceptability and feasibility;Accountability;Alaska Native;Alaska Native population;All of Us Research Program;American Indian Population;American Indians;Area;Awareness;Benefits and Risks;Collaborations;Communication;Communities;community engaged research;community engagement;Community Health;community research;Data;Democracy;design;Development;digital;Educational workshop;Ensure;Equity;Ethics;Evaluation;experience;Exposure to;Feedback;Future;Health;Health Sciences;Health system;improved;Information Dissemination;Information Technology;Informed Consent;innovation;insight;interest;Journals;Knowledge;Language;Learning;Learning Skill;Manuscripts;marginalized community;marginalized population;member;Mental Depression;Methods;Morals;mutual learning;Outcome;Outcomes Research;Participant;Peer Review;Perception;Phase;Pilot Projects;preference;Procedures;Process;prototype;Recommendation;Recording of previous events;Research;Research Design;Research Personnel;Research Project Grants;success;symposium;System;Technical Expertise;Techniques;Technology;technology platform;tool;Trauma;Trust;United States National Institutes of Health;user centered design

PROJECT_TITLE: Co-designing a Technology-based Health Research Results Dissemination Tool with AIAN People

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F16-L(20)L]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: Project Narrative Several anemias, are caused in part by pathologic iron sequestration. In these conditions, chronic immune activation or genetic mutations upregulate the Fe regulating hormone hepcidin, which inhibits the mechanism by which bioavailable iron is mobilized to the extracellular iron-carrier protein transferrin for distribution. Anemia correction in the presence of hepcidin excess can be challenging, as hepcidin-driven iron sequestration also limits the efficacy of iron administered through replacement therapy or nutritional supplementation. This proposal is to develop a new class of direct-to-transferrin iron replacement therapy to efficiently and safely replace iron in anemias with hepcidin excess.

PI_NAMEs: GALE, ERIC MICHAEL (contact)

PROGRAM_OFFICER_NAME: GOLDBERG, ILANA GRACE

PROJECT_TERMS: absorption;Adenine;adverse outcome;Affinity;Albumins;Anemia;Anemia due to Chronic Disorder;Autopsy;Binding;Biological Assay;Biological Availability;Blinded;Blood;Carbohydrates;Cardiovascular system;Caring;Carrier Proteins;Chelating Agents;chemical synthesis;Chemistry;Chronic;Chronic Kidney Failure;Citrates;Clinical;Clinical Chemistry;Combined Modality Therapy;comparative efficacy;Complex;Data;Development;Diphosphates;Dissociation;DNA Sequence Alteration;Dose;drug candidate;Drug Design;Drug Kinetics;Drug Modulation;Drug Screening;drug synthesis;Enterocytes;Erythropoiesis;Erythropoietin;Excretory function;experimental study;Exposure to;extracellular;Formulation;Glutamic Acid;Hematology;Hemodialysis;Hemoglobin;Hepatocyte;hepcidin;Hormones;Hour;immune activation;In Vitro;in vitro Assay;in vivo;Intravenous;Iron;iron absorption;Iron deficiency anemia;Iron Overload;Kinetics;Knockout Mice;lead candidate;Libraries;Ligands;Macrophage;Magnetic Resonance Imaging;Malignant Neoplasms;Messenger RNA;Metabolism;metal transporting protein 1;Modeling;Modification;Molecular;Monitor;mouse model;Mus;nanoparticle;Nutritional;nutritional supplementation;Output;Oxidation-Reduction;Pathologic;Pathology;Pathway interactions;Patients;Performance;Periodicity;Pharmaceutical Preparations;Placebos;Plasma;Population;Potentiometry;Production;Property;prospective;prototype;Recombinant Erythropoietin;Recycling;Refractory;Replacement Therapy;research clinical testing;Risk;Rodent Model;Safety;screening;Serum;Serum Albumin;Signal Transduction;Specificity;standard of care;Sucrose;Therapeutic;Thermodynamics;Thrombosis;Tissues;Toxic effect;Transferrin;Treatment Efficacy;Up-Regulation;uptake;Work

PROJECT_TITLE: A New Paradigm for Iron Replacement Therapy

STUDY_SECTION: HTBT

STUDY_SECTION_NAME: Hemostasis, Thrombosis, Blood Cells and Transfusion Study Section[HTBT]


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Nutrition;Obesity;Patient Safety;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: MINNEAPOLIS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF MINNESOTA

PHR: PROJECT NARRATIVE Adolescent obesity is a major medical and public health concern. Daily self-weighing for weight management has been shown to be effective and safe for weight loss in adults, with no negative psychologic effects, but has not been assessed for weight loss and safety in adolescents with obesity seeking obesity treatment. This proposal will assess patient, parent, and provider perspectives on daily self-weighing on scales connected to clinic adolescents seeking obesity treatment, and use these perspectives to design and conduct a pilot study.

PI_NAMEs: BRAMANTE, CAROLYN T (contact)

PROGRAM_OFFICER_NAME: OSGANIAN, VOULA

PROJECT_TERMS: acceptability and feasibility;Accountability;Address;Adherence;Adolescence;Adolescent;Adolescent and Young Adult;adolescent health;Adolescent obesity;adolescent patient;Adult;adult obesity;age group;arm;Behavior Therapy;Behavioral;Body Image;Body Weight decreased;Cardiometabolic Disease;cardiometabolism;Cessation of life;Clinic;Clinical;clinical care;Counseling;Data;design;Development;diabetes risk;dietary;digital technology;Disease;Eating Behavior;Eating Disorders;Education;efficacy testing;Electronic Health Record;Epidemiologic Methods;evidence base;Extramural Activities;Face;Feedback;Focus Groups;Foundational Skills;Funding;Goals;Habits;Health;Height;High Prevalence;Home;improved;Income;individualized feedback;Intervention;intervention effect;Interview;K-Series Research Career Programs;Life Expectancy;Low income;Measurement;Measures;Medical;Medicine;Mentorship;Methods;Monitor;Moods;multidisciplinary;novel;obese patients;Obesity;obesity treatment;Parents;Patients;Physical activity;Physicians;Pilot Projects;Practice Management;premature;prospective;Provider;psychologic;Psychological reinforcement;Public Health;Randomized;Recommendation;remote monitoring;Research Personnel;Risk;Safety;safety assessment;Scientist;Self Efficacy;Self Perception;Self-control as a personality trait;skills;smart scale;social cognitive theory;Stress;Surveys;Technology;technology intervention;Testing;theories;therapy design;tool;Training Programs;transmission process;treatment as usual;Treatment Efficacy;Weight;weight loss intervention;weight maintenance;Weight maintenance regimen

PROJECT_TITLE: Self-weighing for Weight Management in Adolescents with Obesity

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Clinical Research;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Social Determinants of Health;Women's Health Research

ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: PROJECT NARRATIVE This research will assess barriers to guideline-concordant breast cancer care in Nigeria, and methodically develop and evaluate implementation strategies to promote guideline adoption. The proposed research is relevant to public health because it aims to improve the evidence-based treatment of breast cancer, the leading cause of cancer-related death for women in Nigeria. The results of this work will generate fundamental knowledge and strategies to inform healthcare leaders and policymakers about effective methods to facilitate adoption of evidence-based cancer care in resource-limited settings, thereby promoting treatment that improves survival.

PI_NAMEs: ROMANOFF, ANYA  (contact)

PROGRAM_OFFICER_NAME: RADAEV, SERGEY

PROJECT_TERMS: Acceleration;Address;Adherence;Adopted;Adoption;advanced breast cancer;Africa South of the Sahara;African;Age;anti-cancer research;Belief;Breast Cancer Patient;Breast Cancer Treatment;Breast Oncology;breast surgery;cancer care;Cancer Etiology;cancer health disparity;care delivery;career;Caring;clinical practice;Clinical Practice Guideline;Collaborations;Combined Modality Therapy;Complex;Consolidated Framework for Implementation Research;Country;Data;Databases;Death Rate;design;Development;effective therapy;Evaluation;evidence base;Evidence based treatment;Focus Groups;Foundations;fundamental research;Funding;global health;Goals;Group Interviews;Guideline Adherence;Guidelines;Health Personnel;Health Policy;Health Services Research;Health system;Healthcare;Healthcare promotion;implementation evaluation;implementation framework;implementation science;implementation strategy;improved;improved outcome;Incidence;Individual;Infrastructure;Institution;Intervention;intervention mapping;Interview;Knowledge;low and middle-income countries;Malignant Breast Neoplasm;medical schools;Memorial Sloan-Kettering Cancer Center;Methodology;Methods;multidisciplinary;National Comprehensive Cancer Network;Needs Assessment;Nigeria;Nigerian;Oncology;Oncology Group;Outcome;Participant;Patient-Focused Outcomes;Patients;Pilot Projects;pilot test;Policy Maker;Practice Guidelines;professor;prospective;Provider;provider adherence;Public Health;Questionnaires;Recommendation;Research;Research Activity;research and development;Research Infrastructure;Research Personnel;Resource-limited setting;Resources;Review Literature;Standardization;Structure;Surgical Oncologist;Survival Rate;Teaching Hospitals;tool;Training;Training and Education;treatment guidelines;Universities;uptake;user centered design;Women's mortality;Work

PROJECT_TITLE: Improving Adherence to Breast Cancer Treatment Guidelines in Nigeria

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Aging;Biodefense and Related Countermeasures;Clinical Research;Coronaviruses;Coronaviruses Therapeutics and Interventions;Disability Research;Emerging Infectious Diseases;Infectious Diseases;Lung;Orphan Drug;Rare Diseases;Rehabilitation

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE Hundreds of thousands of American adults survive Acute Respiratory Distress Syndrome (ARDS) each year, but at least half have persistent muscle weakness that results in increased disability, healthcare costs, and mortality. The project aims to improve long-term physical function in ARDS survivors by elucidating pathobiological processes that differ between ARDS survivors who recovery physically and those who do not as novel treatment targets for post-ICU clinic based trials.

PI_NAMEs: BALDWIN, MATTHEW R (contact)

PROGRAM_OFFICER_NAME: ZHOU, GUOFEI

PROJECT_TERMS: Acute;Acute Respiratory Distress Syndrome;Acute respiratory failure;Adult;Affect;Age;Aging;American;Amino Acids;Anti-Inflammatory Agents;biobank;Bioenergetics;Biological;Biological Markers;Biopsy;Blood Flow Cytometry;Clinic;Clinical;cohort;Cohort Studies;Communities;comorbidity;COVID-19;COVID-19 survivors;COVID-19/ARDS;critical period;cytokine;Data;Dehydroepiandrosterone Sulfate;disability;Enrollment;follow-up;Future;GDF15 gene;Gene Expression Profiling;Goals;Growth Factor;Health Care Costs;high dimensionality;Hormonal;hormone deficiency;Hormones;Hospitals;Immune;Impairment;improved;Inflammation;inhibitor;Insulin;interest;Interleukin-6;Intervention;Limb structure;Lung;lung injury;Messenger RNA;metabolomics;Mitochondria;mitochondrial dysfunction;Mitochondrial Myopathies;monocyte;Morphology;mortality;Multi-Ethnic Study of Atherosclerosis;Muscle;Muscle Mitochondria;muscle strength;Muscle Weakness;National Heart, Lung, and Blood Institute;Nested Case-Control Study;novel;older adult;Outcome;Patients;Persons;Physical Function;physical impairment;physically handicapped;Plasma;Process;prospective;randomized trial;Recovery;Research Priority;Role;Serum;Skeletal Muscle;sociodemographics;Source;Supplementation;Survivors;systemic inflammatory response;targeted therapy trials;targeted treatment;Testosterone;therapeutic target;Time;TNFRSF1A gene;Universities;University Hospitals;vastus lateralis;Walking;Work

PROJECT_TITLE: Immune, hormonal, and muscle mitochondrial determinants of recovery in Acute Respiratory Distress Syndrome survivors

STUDY_SECTION: CRD

STUDY_SECTION_NAME: Cardiovascular and Respiratory Diseases Study Section[CRD]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Vaccines;Dissemination and Implementation Research;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunization;Infectious Diseases;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Vaccine Related

ORG_CITY: ANCHORAGE

ORG_NAME: SOUTHCENTRAL FOUNDATION

ORG_STATE: AK

PHR: PROJECT NARRATIVE Alaska Native and American Indian (ANAI) people in the state of Alaska are twice as likely as the general population to contract SARS-CoV-2, are at elevated risk for hospitalization and death from COVID-19, and vaccination remains low. To increase COVID-19 vaccine uptake among ANAI people in Alaska we will train and support ANAI community members to serve as community vaccine advocates by providing information, motivational strategies, and Web-based tools to help them talk with vaccine-hesitant friends and family about COVID-19 vaccines. Broader applicability includes the development of new approaches to vaccine outreach and engagement in ANAI communities, one that leverages peer relationships, social networks, and eHealth to promote health education and behavior change.

PI_NAMEs: BEANS, JULIE  (contact);COLLIER, ANN D;TRINIDAD, SUSAN BROWN

PROGRAM_OFFICER_NAME: BOZICK, BROOKE ALLISON

PROJECT_TERMS: 2019-nCoV;Address;Adult;Advocate;Age;Alaska;Alaska Native;Alaskan;American Indian community;American Indian Population;American Indians;Attitude;Awareness;Behavior;Belief;cohesion;Communities;community advisory board;community intervention;Contracts;COVID-19;COVID-19 disparity;COVID-19 morbidity;COVID-19 mortality;COVID-19 vaccination;COVID-19 vaccine;culturally appropriate intervention;Data;design;Development;Education;Effectiveness;effectiveness evaluation;Effectiveness of Interventions;eHealth;Eligibility Determination;Emotional;Ensure;Equity;Evaluation;evidence base;experience;Family;Feedback;Friends;Future;General Population;Geography;Goals;Grain;Health;Health behavior change;health organization;Health Planning;Health Promotion and Education;Hospitalization;human old age (65+);improved;Incidence;Individual;Intervention;intervention refinement;Interview;Knowledge;member;mortality;Motivation;Not Hispanic or Latino;novel;novel strategies;outreach;Participant;Pattern;peer;Persons;Population;Prevalence;programs;Public Health;Qualitative Methods;Quasi-experiment;Race;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Reporting;Research;Risk;Rural;rural Alaska;rural area;SARS-CoV-2 infection;social;Social Network;Surveys;Technology;Testing;theories;therapy design;tool;Training;tribal health;United States;uptake;urban area;urban residence;Use Effectiveness;Vaccinated;Vaccination;vaccine acceptance;vaccine distribution;vaccine hesitancy;Vaccines;volunteer;web-based tool;Work

PROJECT_TITLE: Alaska Native Communities Advancing Vaccine Uptake

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-N(90)]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Aging;Clinical Research;Dental, Oral, and Craniofacial Disease;Immunotherapy;Infectious Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: PITTSBURGH

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project Narrative Proper regulation of inflammation within bone is critical for preventing disease and healing from injury. A dysregulated immune response becomes more prevalent in elderly populations and results in a susceptibility to numerous conditions, including periodontal disease. The goal of this project is to understand the age-related perturbations that occur to the cellular and molecular regulators of the innate immune response in bone.

PI_NAMEs: CLARK, DANIEL R. (contact)

PROGRAM_OFFICER_NAME: THIRUMANGALATHU, SHOBA

PROJECT_TERMS: Adult;Affect;Age;age effect;age related;age related changes;aged;Aging;Award;Basic Science;Bioinformatics;Biological;Biology;Biology of Aging;bone;career;career development;cell age;Cell Communication;Cell Line;Cell Therapy;Cells;cellular targeting;Clinical;clinically significant;Coculture Techniques;cost;cytokine;Data;Data Set;Dentists;Disease;Disease Progression;Down-Regulation;Elderly;Epithelial Cells;Gene Expression Profile;Genetic;Genetic Transcription;Gingiva;Goals;Grant;healing;IL17 gene;Immune;Immune response;Immune system;Immune System Diseases;Immunologist;immunomodulatory strategy;immunomodulatory therapies;immunoregulation;improved;Infection;Inflammation;Inflammation Mediators;Inflammatory;Inflammatory Response;Injury;Innate Immune Response;innovation;interleukin-23;Interleukin-6;Investigation;K-Series Research Career Programs;Macrophage;Mediating;Mentors;Mentorship;Mesenchymal Stem Cells;Methods;Molecular;Molecular Target;mouse model;Mus;new therapeutic target;novel;old mice;osteoimmunology;Pathogenesis;Pathogenicity;Pathologic;pathological aging;Pathology;Periodontal Diseases;Periodontitis;pharmacologic;Phenotype;Population;Predisposition;Prevalence;prevent;Process;Production;Productivity;programs;Publications;Regulation;Rejuvenation;Research;Research Personnel;Research Training;Resolution;response;Scientist;Severities;Severity of illness;Signal Transduction;single cell analysis;skills;T-Lymphocyte;Techniques;Testing;therapeutic target;Tooth Loss;Tooth structure;Training;transcriptomics;TREM2 gene;United States;Work;Writing

PROJECT_TITLE: The impact of the aging immune system on periodontal disease

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


ADMINISTERING_IC: EY

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Clinical Research;Eye Disease and Disorders of Vision;Neurosciences

ORG_DEPT: PSYCHOLOGY

ORG_NAME: NEW YORK UNIVERSITY

PHR: Project Narrative We have systematically investigated how visual perception –discriminability– varies across the visual field, along eccentricity and across polar angle. Here, we propose to investigate how and why these differences come about; i.e., the neural and computational mechanisms underlying the differential effects across eccentricity and polar angle. These results will establish normative data sets on adults’ perception and neuroimaging as a function of stimulus location in the visual field, enabling comparison with patient populations (e.g., ADHD and autism), and advance our knowledge of neural and computational mechanisms responsible for visual perception.

PI_NAMEs: CARRASCO, MARISA  (contact);WINAWER, JONATHAN A

PROGRAM_OFFICER_NAME: WIGGS, CHERI

PROJECT_TERMS: Adult;Area;area striata;Attention deficit hyperactivity disorder;autism spectrum disorder;Basic Science;Behavior;Behavioral;Brain;cognitive neuroscience;computer aided detection;Computer Models;Computer software;Computing Methodologies;Contrast Sensitivity;cortex mapping;Data;Data Set;design;detection platform;Diagnosis;Disease;ergonomics;falls;fovea centralis;Frequencies;Functional Magnetic Resonance Imaging;Funding;gaze;Goals;Human;Image;improved;Individual;Individual Differences;Knowledge;Link;Location;Macular degeneration;Measures;Mediating;Meridians;Modeling;neural;neuroimaging;Noise;patient population;Perception;Performance;Population;Property;Protocols documentation;Psychophysics;Public Health;Radial;radiological imaging;receptive field;Research;Resolution;Resources;response;Retina;Retinitis Pigmentosa;scaffold;Sensory;spatial vision;Stimulus;Surface;System;Testing;theories;Translational Research;Variant;Vision;Visual;Visual Cortex;visual dysfunction;Visual Fields;visual information;Visual Perception;visual performance;Visual System

PROJECT_TITLE: Linking brain and behavior across and around the visual field


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative: The CF RTCC provides a mechanism to accelerate the development of novel therapies for cystic fibrosis. Novel therapies will include both molecular and small molecule-based approaches. The principles and, indeed, therapies for CF may have broad applications to a spectrum of GI and pulmonary diseases that affect residents of the U.S.

PI_NAMEs: BOUCHER, RICHARD CHARLES (contact)

PROGRAM_OFFICER_NAME: EGGERMAN, THOMAS L

PROJECT_TERMS: Acceleration;Adhesions;Advisory Services;Affect;airway epithelium;base;Biochemical;Biochemistry;Biogenesis;Biological Assay;biomarker development;Biometry;biophysical properties;Biophysics;Biopsy;Caring;Cell Culture Techniques;cell immortalization;Cell model;Cells;Cellular biology;Clinical;clinical care;Clinical Research;Clinical Services;clinical translation;cohesion;Combined Modality Therapy;Communication;Communities;Coupled;Cystic Fibrosis;cystic fibrosis patients;Cystic Fibrosis Transmembrane Conductance Regulator;design;Development;Disease;Environment;Epithelial Cells;Epithelium;experience;Faculty;Fostering;Friction;gastrointestinal;Gastrointestinal tract structure;Gene Modified;gene therapy;gene transfer vector;Genetic;Genotype;Goals;Human;Immunology;improved;In Vitro;in vivo;in vivo evaluation;induced pluripotent stem cell;Interdisciplinary Study;interest;International;Ion Transport;Kinetics;Left;Lung;Lung Diseases;Magnetic Resonance Imaging;Measurement;Measures;Metabolic;Microbiology;Modeling;Molecular;molecular modeling;Monoclonal Antibody F19;Mucins;Mucous body substance;Mus;mutant;new chemical entity;next generation;novel;novel imaging technology;novel marker;novel therapeutics;Organoids;Oryctolagus cuniculus;Osmotic Pressure;Pancreas;Pancreatic duct;Pathogenesis;Patients;Pharmacotherapy;Phenotype;Positioning Attribute;Process;programs;Quality Control;Rattus;Reagent;repository;Research;Research Personnel;response;Sampling;Services;single-cell RNA sequencing;small molecule;Specimen;Sputum;stem cells;synergism;System;Techniques;Technology;testing services;Therapeutic;Therapeutic Agents;therapeutic biomarker;therapeutic development;Therapeutic Studies;therapy development;Training Programs;Translations;ventilation

PROJECT_TITLE: UNC Cystic Fibrosis Research and Translation Core Center


NIH_SPENDING_CATS: Cystic Fibrosis;Lung;Rare Diseases

PROJECT_TERMS: Biological Markers;Biometry;Budgets;Clinical Research;clinical translation;Communication;Communities;Cystic Fibrosis;Feedback;Financial Activity;Foundations;Guidelines;Leadership;Lung;member;National Institute of Diabetes and Digestive and Kidney Diseases;Process;programs;Research;Research Personnel;Resources;Services;Specimen;synergism;Tissues;Training Activity;Training Programs;Translations;Visit

PROJECT_TITLE: Core A: Administrative Core


NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Clinical Research;Congenital Heart Disease;Congenital Structural Anomalies;Heart Disease;Infant Mortality;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: PROJECT NARRATIVE Tricuspid regurgitation is associated with a significant risk of morbidity and mortality in children with Hypoplastic Left Heart Syndrome (HLHS). However, the underlying mechanisms of tricuspid regurgitation remain unclear given the limitations in obtaining appropriate tricuspid valve tissue properties and morphologies. The proposed study will leverage physics-informed machine learning and 3D echocardiography- derived finite element modeling to develop patient-specific tricuspid valve models that will be used to delineate the cause of tricuspid valve regurgitation in a small cohort of HLHS patients.

PI_NAMEs: WU, WENSI  (contact)

PROGRAM_OFFICER_NAME: WANG, WAYNE C

PROJECT_TERMS: Address;Affect;Age;Anatomy;Animal Model;Area;Award;Biomechanics;Biomedical Research;Blood;Cardiac;Cardiovascular Diseases;Cardiovascular system;career;Chest;Child;Childhood;Circulation;Clinical;clinical translation;cohort;Communities;Computational Science;Computer Analysis;computer framework;Computer Models;computer studies;Data;design;Development;Doctor of Philosophy;Drug or chemical Tissue Distribution;Elements;Engineering;Environment;Etiology;Exposure to;Extravasation;Failure;Finite Element Analysis;Floods;Functional disorder;Future;Geometry;Goals;Heart;Heart failure;Heart Valve Diseases;Heart Valves;Height;Heterogeneity;Hypoplastic Left Heart Syndrome;Image;image registration;improved;indexing;Individual;individual patient;Infant;insight;Intervention;Investigation;knowledge base;Learning;Left;Machine Learning;Mentors;Methods;Modeling;Morbidity - disease rate;Morphology;mortality;mortality risk;multidisciplinary;neonate;novel;Operative Surgical Procedures;Pathology;Patients;Pediatric Hospitals;Pennsylvania;Phase;Philadelphia;Physics;Population;Population Heterogeneity;Positioning Attribute;prevent;Procedures;Property;Reconstructive Surgical Procedures;repaired;Research;Research Personnel;response;Risk;Science;scientific computing;Scientist;Series;Severities;shape analysis;Single ventricle congenital heart disease;skills;sound;Stress;Structure;success;surgery outcome;Survivors;Techniques;Technology;Three-Dimensional Echocardiography;tissue stress;Tissues;Training;training data;Translating;Tricuspid Valve Insufficiency;Tricuspid valve structure;Universities;virtual;virtual surgery;Work

PROJECT_TITLE: Toward Patient-Specific Computational Modeling of Tricuspid Valve Repair in Hypoplastic Left Heart Syndrome

STUDY_SECTION: MTI

STUDY_SECTION_NAME: NHLBI Mentored Transition to Independence Study Section[MTI(JA)]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cystic Fibrosis;Genetics;Lung;Microbiome;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

PI_NAMEs: GENTZSCH, MARTINA  (contact)

PROJECT_TERMS: advanced analytics;Affect;Airway Disease;Animal Model;Anti-Infective Agents;Anti-Inflammatory Agents;Basic Science;Biochemical;Biological Assay;Biological Models;Biology;Biophysics;Biopsy;Caucasians;Cell model;Cells;Clinical Research;clinical translation;Collaborations;Cystic Fibrosis;cystic fibrosis mouse;cystic fibrosis patients;Cystic Fibrosis Transmembrane Conductance Regulator;Defect;Development;Disease;drug candidate;Drug Kinetics;effective therapy;epithelial Na+ channel;Epithelium;Evaluation;experience;faculty support;Functional disorder;gastrointestinal;Gastrointestinal tract structure;Gene Expression;gene therapy;Genes;Genetic Diseases;Genotype;Gnotobiotic;Goals;gut inflammation;high throughput screening;Histopathology;Hydration status;Hypoxia;Immune;In Situ Hybridization;In Vitro;in vitro Assay;in vivo evaluation;in vivo Model;Infection;Infection Control;Inflammation;Intervention;Ion Channel;Ion Transport;Laboratories;Lung;Lung Diseases;Maintenance;Mass Spectrum Analysis;Measurement;Measures;Mediating;microbiome;microbiome analysis;microorganism interaction;model development;Modeling;Molecular;mouse model;Mucins;Mucolytics;Mucous body substance;Mus;Mutant Strains Mice;Mutation;North Carolina;Nose;novel;novel therapeutics;Organ;Organoids;Oryctolagus cuniculus;Outcome;overexpression;Pathogenicity;Pharmacodynamics;pharmacokinetics and pharmacodynamics;pharmacologic;Phenotype;Physiological;Population;pre-clinical;Preparation;programs;Protein Analysis;Research;restoration;RNA Splicing;Rodent;saliva secretion;sample collection;Services;small molecule;Specimen;stem cell therapy;stem cells;success;Swelling;Technology;Testing;Therapeutic;Therapeutic Agents;therapeutic candidate;Therapeutic Effect;therapy development;Transgenic Organisms;Translating;Translations;treatment strategy;Universities

PROJECT_TITLE: Core B: Molecular/Functional Measurement Core


ADMINISTERING_IC: GM

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: CAMBRIDGE

ORG_DEPT: MISCELLANEOUS

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

PHR: PROJECT NARRATIVE Regulating the amount of water inside a cell is critical for all cells, and mutations water transporting channels cause severe diseases. However, there are currently no precise and non-invasive methods to measure the water content of single cells, and we are proposing solve this lack of research tools by developing a non-invasive method for directly measuring the absolute and fractional (v/v) water content of a single cell or an organoid. This method will enable novel basic and biomedical research that will increase our understanding of water content regulation in health and disease, and provide a new platform for drug discovery.

PI_NAMEs: MANALIS, SCOTT R (contact);MIETTINEN, TEEMU PETTERI

PROGRAM_OFFICER_NAME: SALVADOR MORALES, CAROLINA

PROJECT_TERMS: Acute;Area;Basic Science;Biochemistry;Biological;Biomedical Research;biophysical properties;Cell Cycle;cell growth;Cell membrane;Cell Physiology;Cell Survival;cell water;Cells;Cellular biology;cellular imaging;Complex;Crowding;density;Detection;Deuterium Oxide;Disease;drug discovery;Drug Exposure;Dryness;Exclusion;Exposure to;Fluorescence;fluorescence imaging;Genetic Diseases;Growth;Health;Hour;Immune;Immunologic Surveillance;Immunomodulators;in vivo;Liquid substance;Macrophage;Measurement;Measures;Methods;Mitosis;Molecular;Monitor;Mutate;Mutation;Normal Cell;novel;Organoids;Outcome;particle;Pharmaceutical Preparations;Phenotype;prevent;Process;Regulation;Research;Role;Sampling;spheroids;stem cell division;System;Time;tool;tumor;virtual;Water;water channel;water testing

PROJECT_TITLE: Measuring single-cell water content non invasively and with high precision

STUDY_SECTION: EBIT

STUDY_SECTION_NAME: Enabling Bioanalytical and Imaging Technologies Study Section[EBIT]


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Cystic Fibrosis;Digestive Diseases;Lung;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Nonembryonic - Human

PI_NAMEs: RANDELL, SCOTT H (contact)

PROJECT_TERMS: 3-Dimensional;Accountability;Air;airway epithelium;Animals;Anti-Infective Agents;bench-to-bedside translation;Biological Assay;Biological Models;Biomedical Engineering;Blood Vessels;Cell Culture Techniques;Cell Differentiation process;Cell Line;Cell model;Cell Physiology;cell preparation;Cell Therapy;cell type;Cells;Cellular biology;Charge;Clinical Trials;Collaborations;Community Medicine;Competence;cost;Culture Media;Cystic Fibrosis;cystic fibrosis airway epithelia;Cystic Fibrosis Transmembrane Conductance Regulator;Development;directed differentiation;Doctor of Philosophy;Ductal Epithelial Cell;Ecology;Effectiveness;Electrophysiology (science);Elements;Environment;Epithelial Cells;Esophagus;Family suidae;Fee-for-Service Plans;Fibroblasts;Future;Gastrointestinal tract structure;Gene Expression;gene therapy;Genes;genetic manipulation;Goals;Human;Hypoxia;In Vitro;in vivo;Individual;induced pluripotent stem cell;Inflammation;innovation;International;intestinal epithelium;Intestines;Ion Channel;Laboratories;Liquid substance;Medicine;member;Methods;microbial;mid-career faculty;minimally invasive;Modeling;Motion;Mucins;Mucous body substance;Mus;mutant;Mutation;North Carolina;novel;novel therapeutics;organ on a chip;Organoids;Oryctolagus cuniculus;Output;Pancreas;Pancreatic duct;Pathogenesis;personalized approach;Pharmaceutical Preparations;Pharmacotherapy;Phase;Physiological;Preclinical Testing;Primary Cell Cultures;Process;Productivity;Property;Publications;Rattus;Recording of previous events;Reproducibility;Research;research and development;Research Personnel;Resources;response;restoration;Services;Source;Specimen;spheroids;Stress;System;Techniques;Technology;Testing;tissue processing;Tissue Procurements;Tissues;trafficking;Training;Training Support;Translating;translational medicine;Translations;Universities;uptake;vector;Visit

PROJECT_TITLE: Core C: Cell Models Core


PI_NAMEs: BUTTON, BRIAN M (contact)

PROJECT_TERMS: Acceleration;Adhesions;Affect;airway epithelium;Animals;anti-microbial peptide;Antibodies;Area;Atomic Force Microscopy;Bacteria;Basic Science;Bicarbonates;Biochemical;Biochemistry;Biological Assay;biophysical properties;Biophysics;Biopsy;Body System;Cell Culture Techniques;Cell model;Cell surface;Cells;Characteristics;Chlorides;Cilia;Collaborations;Complex Mixtures;Coupled;Cystic Fibrosis;cystic fibrosis mucus;Cystic Fibrosis Transmembrane Conductance Regulator;Data;Dehydration;design;Disease;DNA;Doctor of Philosophy;drug development;Elasticity;Environment;Epithelial Cells;Epithelium;Event;Exhibits;Exposure to;extracellular;Fluorescent in Situ Hybridization;Friction;Functional disorder;gastrointestinal;gastrointestinal system;Gastrointestinal tract structure;Gel;Glycoproteins;Goals;Growth;Health;histological image;Human;Image;In Vitro;in vitro Assay;Individual;Inflammatory Response;Intestines;Ion Transport;Laboratories;Lavage;Lung;Measurement;Measures;Mediating;molecular size;Molecular Weight;Muc 2 protein;MUC5AC gene;MUC5B gene;Mucin 1 protein;Mucin-2 Staining Method;Mucins;Mucous body substance;Mucous Membrane;mucus clearance;new technology;Normal Range;novel;Organ;Osmotic Pressure;pathogen;Pathogenesis;Patients;persistent bacterial infection;Persons;pharmacologic;Play;Positioning Attribute;Production;Property;Proteins;Reagent;Reproductive system;reproductive tract;Research;Research Personnel;Respiratory System;Role;Salts;Sampling;Scanning Electron Microscopy;Scientist;Series;Services;Small Intestines;Solid;Surface;System;Techniques;Technology;Therapeutic;Therapeutic Agents;Therapeutic Effect;tissue culture;tool;Toxin;Translations;viscoelasticity;Viscosity;Water;zeta potential

PROJECT_TITLE: Core D: Mucus Biochemistry/Biophysics Core


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Cocaine;Drug Abuse (NIDA only);Genetics;Human Genome;Mental Health;Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: ANN ARBOR

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Only some people are tempted to experiment with drugs of abuse, and only a portion of them become true addicts. To understand the genetic and environmental reasons behind a person's vulnerability to addiction, we used selective breeding to generate two lines of rats that differ significantly in their tendency to experiment with drugs and become addicted.  In this project, we use state of the art genetic and genomic techniques to discover the genetic and brain causes of their differences and provide insights into the biology of addiction in humans.

PI_NAMEs: AKIL, HUDA  (contact);LI, JUN ;WATSON, STANLEY J

PROGRAM_OFFICER_NAME: LOSSIE, AMY C

PROJECT_TERMS: addiction;Addictive Behavior;Address;Affect;American;Anatomy;Animal Model;Animals;Anxiety;anxious behavior;Area;ATAC-seq;Behavior;Behavioral;Biological Assay;Biology;Brain;brain metabolism;Brain region;Breeding;Candidate Disease Gene;causal variant;CCRL2 gene;Cell Nucleus;cell type;Cells;Characteristics;Chromatin;Chronic;clinically relevant;Cocaine;cocaine seeking;cocaine self-administration;Cue-induced relapse;depressive behavior;Disease;DNA;Drug abuse;Drug Addiction;Drug Experimentation;drug of abuse;drug seeking behavior;Emotional;Environment;Environmental Risk Factor;epigenetic regulation;Esthesia;Exhibits;Female;Fluorescent in Situ Hybridization;Funding;Future;Gene Expression;Gene Expression Profile;Gene Expression Regulation;Genes;Genetic;genetic architecture;genetic selection;Genetic Transcription;genome sequencing;genome-wide;Genomics;Genotype;Goals;Heritability;High-Throughput Nucleotide Sequencing;Hippocampus;Human;Impulsivity;Individual;Individual Differences;insight;Intervention;Learning;Link;Locomotion;male;Mental Depression;Microglia;Modeling;Molecular;multiple omics;neural;neural circuit;neural patterning;Neurobiology;Neurons;Neurosciences;new technology;novel;Nucleus Accumbens;Pathway interactions;Personality Traits;personalized approach;Persons;Pharmaceutical Preparations;pharmacologic;Phase;Phenotype;Play;Population;Predisposition;Psychosocial Stress;psychostimulant;Quantitative Trait Loci;Rattus;Reaction;Recommendation;Regulation;Relapse;Research;response;Role;Selection Criteria;Shapes;Societies;Specificity;Sprague-Dawley Rats;stimulant abuse;stimulant use;Stress;stress reactivity;substance abuse prevention;Substance abuse problem;Substance Use Disorder;Techniques;Technology;Temperament;Text;tool;trait;Transcript;transcriptome sequencing;transcriptomics;Transposase;Variant;Vulnerable Populations;whole genome

PROJECT_TITLE: Genetics of novelty seeking and propensity for drug abuse in outbred rats


NIH_SPENDING_CATS: Biomedical Imaging;Clinical Research;Cystic Fibrosis;Digestive Diseases;Lung;Rare Diseases

PI_NAMEs: DONALDSON, SCOTT H (contact)

PROJECT_TERMS: Address;airway inflammation;Applications Grants;Ascending colon;Basic Science;biobank;Bioinformatics;Biology;Biometry;Biopsy;Clinical;Clinical Investigator;clinical outcome measures;Clinical Research;clinical translation;clinically relevant;Colonoscopy;Consultations;Curettage procedure;Cystic Fibrosis;cystic fibrosis patients;Cystic Fibrosis Transmembrane Conductance Regulator;Data Analyses;Databases;Disease;Doctor of Philosophy;Drug Kinetics;Endoscopy;Ensure;Epithelial Cells;Esophagus;Exhalation;fundamental research;Funding;gastrointestinal;Gene Expression;Goals;Human;ileum;Image;imaging biomarker;Institution;intestinal epithelium;Intestines;Lung;Magnetic Resonance Imaging;Maintenance;metabolomics;Metagenomics;microbial;microbiota;Molecular;Mucociliary Clearance;Mucous body substance;Mucous Membrane;Nasal Epithelium;novel;novel marker;Outcome Measure;Pathogenesis;Patients;Persons;Pharmaceutical Preparations;Physical condensation;Population;Population Control;Procedures;Process;programs;protein expression;Pulmonary Cystic Fibrosis;Radionuclide Imaging;Rectum;repository;Research;Research Design;Research Personnel;research study;Resources;respiratory;sample collection;Sample Size;Sampling;Services;Shotguns;Specimen;Sputum;Stomach;stool sample;Symptoms;Tissues;tool;Translating;Translational Research;Translations;treatment center;trial design;Upper digestive tract structure;ventilation;Work

PROJECT_TITLE: Core E: Clinical Translation Core


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: Overall Project Narrative Maintaining normal lung function and inducing repair of damaged lung can be markedly improved if we better understand the cellular and molecular complexities of the organ. It is the goal of HuBMAP and of this Lung Tissue Mapping Center to generate findable, accessible, interoperable, and reusable, interactive, and annotated maps of structure, cell type and cell subtype, integrated into a reference atlas of healthy lung to which diseased lung can be compared, ultimately to identify mechanisms of disease and therapeutic interventions for a major public health concern, the ability to breathe.

PI_NAMEs: PRYHUBER, GLORIA S (contact)

PROGRAM_OFFICER_NAME: LIN, SARA

PROJECT_TERMS: 3-Dimensional;Adult;Alveolus;Anatomy;Atlases;Biological Assay;Biology;Body System;Breathing;California;Cell Physiology;cell type;Cells;Chromatin;clinical care;Collaborations;collaboratory;Collection;Communication;Community Healthcare;Data;Data Analyses;Data Collection;data management;data portal;data sharing;Dimensions;Disease;Education;Educational workshop;Elements;expectation;experience;Experimental Designs;FAIR principles;Gene Expression;Goals;Human;Human BioMolecular Atlas Program;Image;improved;indexing;Institution;interest;International;interoperability;Knowledge;Laboratories;Leadership;Learning;Lipids;Location;Lung;Lung Diseases;lung injury;Maps;meetings;member;Microscopy;Molecular;multi-scale atlas;Names;new technology;Nomenclature;North Carolina;novel strategies;Organ;Pacific Northwest;Phase;Post-Translational Protein Processing;Production;Productivity;programs;Proteins;Protocols documentation;Public Health;pulmonary function;Recording of previous events;repaired;Research;Research Personnel;Resolution;Resource Sharing;Resources;Respiratory System;Sensitivity and Specificity;single nucleus RNA-sequencing;Standardization;Structure;Structure of parenchyma of lung;success;synergism;Technology;Therapeutic Intervention;tissue mapping;tissue resource;Trachea;transcriptomics;United States National Institutes of Health;Universities;Visualization;Washington;working group

PROJECT_TITLE: The Human Lung BioMolecular Multi-Scale Atlas Program (HuBMAP-Lung)


NIH_SPENDING_CATS: Bioengineering;Data Science;Lung;Networking and Information Technology R&D (NITRD)

PROJECT_TERMS: 3-Dimensional;Adult;Anatomy;Atlases;Cells;cluster computing;Collection;computerized data processing;Consensus;Data;Data Analyses;Data Collection;data format;data ingestion;data integration;data quality;Data Set;data sharing;Data Storage and Retrieval;Environment;Equipment;experience;extracellular;FAIR principles;Health Insurance Portability and Accountability Act;High Performance Computing;Human;Human BioMolecular Atlas Program;Human Resources;Image;indexing;Ingestion;Institution;interoperability;Link;Location;Lung;Maps;Metadata;Modality;Molecular;multi-scale atlas;multimodality;Names;novel;Ontology;open source tool;Organ;Output;Positioning Attribute;Procedures;Process;Production;programs;Protocols documentation;Reproducibility;Resolution;Resources;Role;Secure;Signal Transduction;spatial relationship;statistical and machine learning;Structure of parenchyma of lung;Systems Biology;tissue mapping;tool;Universities;virtual machine;Work

PROJECT_TITLE: Multi-Scale Multi-Modality High Resolution Mapping of the Adult Human Lung

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IMST-U]


PROJECT_TERMS: Advertisements;Advisory Committees;Applications Grants;Area;Cystic Fibrosis;Databases;Development;Disclosure;Electronic Mail;Elements;experience;Fluids and Secretions;Functional disorder;Funding;gastrointestinal epithelium;Gastrointestinal tract structure;Gel;gene therapy;Goals;Grant;Guidelines;Health Service Area;Investigation;Lung;meetings;member;Mission;Modeling;Mucins;Mucous body substance;National Institute of Diabetes and Digestive and Kidney Diseases;Needs Assessment;NIH Program Announcements;novel;Oral;Pattern;Pilot Projects;Process;programs;Regulation;Research;Research Personnel;response;Science;small molecule;stem cells;Structure;success;Therapeutic;translational therapeutics;Translations;United States National Institutes of Health;web site

PROJECT_TITLE: Pilot & Feasibility Program


PROJECT_TERMS: 3-Dimensional;Adult;advanced analytics;Age;Alveolar;Alveolar Duct;Anatomy;ATAC-seq;Atlases;biobank;Biodiversity;Biological Assay;Biological Markers;Biology;bronchial artery;Bronchioles;Cell Nucleus;cell type;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Chemicals;Chromosome Mapping;Collaborations;Communities;Consensus;Data;Data Set;Distal;epigenome;epigenomics;Equilibrium;Gene Expression;Generations;Genes;Genome;genome sequencing;Genomics;Goals;Human;Human BioMolecular Atlas Program;Image;Imaging technology;Immune system;Immunofluorescence Immunologic;improved;In Situ;Individual;Infrastructure;innovation;interest;International;Intrapulmonary Bronchus;Investigation;Leadership;Lipids;Lung;Lung Diseases;lung injury;Lymphatic System;Maps;Mass Spectrum Analysis;metabolome;metabolomics;Methods;Microdissection;Microscopy;Molecular;molecular imaging;Morphology;multi-scale atlas;multimodality;multiple omics;Nature;Nervous System;Nomenclature;novel;Organ;Organ Transplantation;Patient Self-Report;Phase;Pleural;Positioning Attribute;Post-Translational Protein Processing;preservation;programs;Proteins;Proteome;pulmonary function;Race;Raman Spectrum Analysis;reconstruction;Recovery;repaired;Reproducibility;Resolution;respiratory;Respiratory System;Role;Sampling;sex;single nucleus RNA-sequencing;Specificity;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;Spectrum Analysis;Standardization;Structure;Structure of parenchyma of lung;Techniques;Technology;Terminal Bronchiole;Thick;Three-Dimensional Imaging;Tissue imaging;tissue mapping;Tissue Microarray;Tissue Sample;Tissues;Trachea;transcriptome;transcriptomics;Variant;Vascular System;whole genome

PROJECT_TITLE: Synthesis of the Multi-Modality High Resolution 3-D Atlas of Human Lung


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_CITY: Research Triangle Park

ORG_NAME: EPICYPHER, INC.

PHR: PROJECT NARRATIVE  Genomic mapping of chromatin features including histone post-translational modifications, chromatin- associated proteins, and DNA methylation is a powerful approach for biomedical research and drug development. Current genomics assays rely on second generation short-read sequencing, wherein short reads limit the ability to analyze concordance of epigenomic features on a single molecule and preclude analysis of repetitive genomic regions. Here, EpiCypher is developing the first commercial genomic mapping approach that leverages long-read sequencing, a multiomic platform that will enable deconvolution of heterogeneity from mixed samples and mapping into challenging genomic regions.

PI_NAMEs: BURG, JONATHAN MICHAEL (contact);KEOGH, MICHAEL-CHRISTOPHER

PROGRAM_OFFICER_NAME: YU, GUOQIN

PROJECT_TERMS: Antibodies;Automation;Benchmarking;Biological Assay;biomarker discovery;Biomedical Research;bisulfite sequencing;Blood specimen;cancer cell;Cell Differentiation process;Cell Line;cell type;Cells;Cellular Assay;Centromere;Chimeric Proteins;ChIP-seq;Chromatin;Cleavage Under Targets and Release Using Nuclease;clinical application;clinically relevant;Collaborations;commercial launch;commercialization;Data;data analysis pipeline;Data Set;Development;DNA;DNA Methylation;DNA Modification Methylases;DNA sequencing;drug development;Elements;Enzymes;Epigenetic Process;epigenomics;Gene Expression Regulation;Generations;Genetic Transcription;Genome;Genomic approach;Genomic Segment;Genomics;Heterogeneity;Histones;human disease;innovation;interest;Label;Maps;Marketing;Measures;Methylation;multiple omics;novel;paralogous gene;Pathway interactions;peripheral blood;Phase;Population;Post-Translational Protein Processing;preservation;Production;Protein Methylation;Proteins;Protocols documentation;Repetitive Sequence;research and development;Resolution;response;Sampling;sequencing platform;Signal Transduction;single molecule;Stretching;targeted sequencing;telomere;Universities;Validation;Work

PROJECT_TITLE: Multiomic genomic mapping with long read sequencing


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Narrative This application describes the development of a novel mouse model that allows the visualization of cancer formation at its earliest stages, as well as the visual monitoring of immune evasion by cancer cells. This model will be used to test the possibility of activating the immune system to eliminate cancers at an early stage before they progress to overt tumors. This model may also allow the discovery of novel immunotherapy targets for treating patients who do not respond to current generation immunotherapeutics.

PI_NAMEs: ROOP, DENNIS  (contact)

PROGRAM_OFFICER_NAME: UNDALE, ANITA H

PROJECT_TERMS: Academia;Address;anti-PD-L1;Biopsy;cancer cell;cancer immunotherapy;cancer prevention;cancer therapy;candidate identification;candidate marker;carcinogenesis;cell transformation;Cells;Chimeric Proteins;Confocal Microscopy;Data;Development;differential expression;drug efficacy;drug testing;Early Diagnosis;Engineering;Epidermis;Epithelium;Equilibrium;Event;experimental study;Generations;Genomics;Growth;Hair follicle structure;Hair Removal;high risk;Human;Immune;Immune Evasion;Immune system;Immunity;Immunocompetent;Immunologic Monitoring;Immunologic Surveillance;Immunology procedure;immunosuppressed;Immunosuppression;Immunotherapeutic agent;Immunotherapy;In Situ;in vivo;in vivo imaging;Individual;Industry;Intervention;keratinocyte;Lesion;Lymphoid Cell;Maintenance;Malignant Neoplasms;Measurable;Mediating;Mesenchymal;Methods;Modeling;Molecular;mouse model;Multiplexed Ion Beam Imaging;Mus;Natural Killer Cells;neglect;Neoplasms;non-invasive imaging;Normal tissue morphology;novel;organ transplant recipient;Pathway interactions;Patients;Pharmaceutical Preparations;Phase;Play;potential biomarker;prevent;Prevention;Process;Protein Engineering;Resistance development;resistance mechanism;Resolution;Risk;Role;screening;Skin;Skin Cancer;System;Techniques;Testing;Time;Tissue Model;transcriptomics;Transforming Growth Factor beta;Transplantation;tumor;Tumor Escape;tumor growth;Tumor Immunity;Up-Regulation;Visual;Visualization;Waxes

PROJECT_TITLE: Defining the role of innate immune cells in the early stages of immune surveillance of skin cancer by using a novel model that allows in vivo imaging of the immunoediting process.

STUDY_SECTION: ACTS

STUDY_SECTION_NAME: Arthritis, Connective Tissue and Skin Study Section[ACTS]


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences

ORG_DEPT: OPHTHALMOLOGY

PHR: Project Narrative This proposal outlines a plan to develop the technology for measuring the Optoretinogram, or ORG: the all- optical recording of functional activity of retinal neurons and their connections in a living eye. We employ a unique combination of technologies (OCT, adaptive optics, interferometry, eye-tracking) that together enable in vivo access to the early visual processing elements in the retina in humans. In the end, we envision powerful, clinically deployable tools suited to test and accelerate the new generation of treatments aimed at regenerating neurons and neural connections in the eye and visual system.

PI_NAMEs: PALANKER, DANIEL V;ROORDA, AUSTIN ;SABESAN, RAMKUMAR  (contact)

PROGRAM_OFFICER_NAME: LEE, PAEK-GYU

PROJECT_TERMS: Acceleration;Action Potentials;adaptive optics;adaptive optics scanning laser ophthalmoscopy;Affect;Age;analog;Animals;Automobile Driving;Basic Science;Biological Assay;Biological Markers;Biomedical Engineering;Biophysical Process;Cell Culture Techniques;Cell model;cell type;Cells;cellular imaging;Cellular Structures;Clinic;Clinical;clinical application;Collection;Computer Models;computerized data processing;Cone;Data;data acquisition;Data Analyses;design;Detection;Diagnosis;Disease;efficacy evaluation;Electrophysiology (science);Electroretinography;Elements;Event;Evolution;Eye;Eye diseases;Foundations;Functional disorder;ganglion cell;Generations;Goals;Grant;Human;Human Volunteers;Image;imaging approach;improved;in vivo;Individual;inherited retinal degeneration;Interferometry;Ions;Lateral;Light;Location;Machine Learning;Measurement;Measures;Membrane;Methods;millisecond;Monitor;Motion;multi-electrode arrays;mutant;nanometer;neural;neuron regeneration;Neurons;Noise;non-invasive imaging;Optics;Osmosis;patch clamp;Patients;pharmacologic;Pharmacology;Phase;Photic Stimulation;Photoreceptors;Phototransduction;Physiological;Physiology;Positioning Attribute;Property;repaired;Research;Resolution;response;Retina;Retinal Cone;Retinal Degeneration;Retinal Diseases;retinal neuron;Rodent;Rodent Model;Scanning;Signal Transduction;Site;Solid;spatiotemporal;Speed;Stimulus;System;Techniques;Technology;temporal measurement;Testing;Therapeutic Agents;Therapeutic Intervention;Time;tool;Transgenic Model;Translations;Treatment Efficacy;Universities;Vision;visual dysfunction;visual processing;Visual System;visual tracking;Visualization;Washington

PROJECT_TITLE: Optoretinography: All-optical measures of functional activity in the human retina

STUDY_SECTION: ITD

STUDY_SECTION_NAME: Imaging Technology Development Study Section[ITD]


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

PHR: PROJECT NARRATIVE This study is likely to result in a feasible and effective strategy for the training of behavioral health staff and other school personnel in under-resourced rural schools. Linking PBIS with state-of-the-art mental health supports and well-trained school personnel will likely lead to improvement and sustainment of student mental health and academic engagement in rural schools.

PI_NAMEs: EIRALDI, RICARDO B (contact)

PROGRAM_OFFICER_NAME: SAGATOV, ROBYN

PROJECT_TITLE: Development and Pilot Testing of a Remote Training Strategy for the Implementation of Mental Health Evidence-Based Practices in Rural K-8 Schools

STUDY_SECTION: HEOR

STUDY_SECTION_NAME: Healthcare Effectiveness and Outcomes Research[HEOR]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Data Science;Networking and Information Technology R&D (NITRD);Patient Safety;Precision Medicine

ORG_CITY: INDIANAPOLIS

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Project Narrative The proposed research will provide novel Bayesian statistical models for complex clinical trials data analysis. The aims are to select and verify personalized treatment using patient-derived organoids (PDO) and the paired clinical outcome, identify subgroup-speciﬁc optimal doses for biotherapies by synthesizing information across multi-dimensional heterogeneous data, assess treatment effects of master protocol trials by integrating the con- current and non-concurrent control response outcomes, and provide freely available user-friendly R Shiny apps for both trial design and data analysis to facilitate the broad application of the proposed methods. The overarch- ing goal is to provide efﬁcient and ﬂexible statistical tools to tackle critical and practical data integration problems identiﬁed during the development and conduct of complex clinical trials with heterogeneous health-related data.

PI_NAMEs: ZANG, YONG  (contact)

PROGRAM_OFFICER_NAME: WANG, PEGGY

PROJECT_TERMS: 3-Dimensional;Acceleration;Address;Advocate;Algorithms;arm;Back;Bayesian Method;Bayesian Modeling;Bayesian Network;Benefits and Risks;Big Data;Biological Response Modifier Therapy;biomarker evaluation;Biomedical Technology;Calibration;Clinical;Clinical Data;clinical practice;Clinical Trials;Complex;Computer software;Data;Data Analyses;data integration;Development;Dimensions;Dose;drug discovery;Ethics;flexibility;Goals;graphical user interface;Guidelines;Health;heterogenous data;immunotherapy trials;improved;Individual;Inferior;Likelihood Functions;Meta-Analysis;Methodology;Methods;Modeling;Monitor;Names;Nature;novel;oncology trial;Online Systems;optimal treatments;Organoids;Outcome;participant enrollment;patient safety;patient subsets;Patients;Performance;personalized medicine;Phase;Phase I and II Vaccine Trials;Physicians;Population;Prediction of Response to Therapy;Process;Protocols documentation;Randomized;Research;Research Proposals;Resources;response;Rewards;Scheme;Science;Selection for Treatments;Series;sound;Speed;Statistical Models;stem cells;Subgroup;Surrogate Markers;Survival Rate;Testing;Therapeutic Effect;Time;Tissues;tool;Toxic effect;treatment arm;treatment effect;trial design;tumor growth;Update;user-friendly;web app

PROJECT_TITLE: Use Bayesian methods to facilitate the data integration for complex clinical trials

STUDY_SECTION: CDMA

STUDY_SECTION_NAME: Clinical Data Management and Analysis Study Section[CDMA]


ORG_CITY: OMAHA

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: Project Narrative Nicotine level is a key product characteristic of modern e-cigarette products. The proposed study seeks to examine the effects of e-liquid nicotine concentration levels and vaping devices on between- subjects differences in biomarkers of exposure to tobacco-related toxicants and within-subjects transitions in ENDS-Cigarette and nicotine dependence. Findings from this study can have important implications for future tobacco regulatory sciences of vaping products at the population level.

PI_NAMEs: DAI, HONGYING DAISY (contact)

PROGRAM_OFFICER_NAME: KAUTZ, MARY A

PROJECT_TERMS: 18 year old;4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol;Abstinence;Address;Adult;Authorization documentation;Behavior;Biological Markers;biomarker selection;Carcinogens;Characteristics;Cigarette;Cigarette Smoker;cigarette smoking;cigarette user;combustible cigarette;Cotinine;Creatinine;Data;Dependence;Devices;Dose;Electronic cigarette;electronic liquid;Electronic Nicotine Delivery Systems;Electronics;Exposure to;former smoker;Formulation;Frequencies;Future;Goals;Grant;Harm Reduction;Health;Inhalation;innovation;Interview;JUUL;Knowledge;Link;liquid nicotine;Logic;Lung;Marketing;Measures;Metals;Modeling;Modernization;never smoker;Nicotine;Nicotine Dependence;nicotine exposure;nicotine use;Outcome;Oxidative Stress;Persons;Play;pod mods;Population;Population Assessment of Tobacco and Health;population health;Population Study;prospective;Public Health;Relapse;Reporting;Research;Role;Serum;Smoker;smoking cessation;smoking relapse;Sodium Chloride;Surveys;Testing;Tobacco;tobacco advertising;tobacco exposure;tobacco products;tobacco regulatory science;Tobacco use;toxicant;two-dimensional;United States Food and Drug Administration;uptake;Urine;vaper;vaping

PROJECT_TITLE: Effects of Nicotine Concentration Levels in E-cigarettes on Biomarkers of Exposure to Toxicants and Tobacco Use Behaviors

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-Z(55)R]


ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

ORG_STATE: CA

PHR: PROJECT NARRATIVE Current observational evidence of the association between vaping and smoking cessation using national longitudinal data sources (e.g., the PATH study) may provide insufficient temporal precision due to the long inter- survey intervals (e.g., 12-month) in which many smokers may make multiple quit attempts and vacillate between abstinence and smoking. Leveraging the nationally-representative longitudinal panel survey of US adults with 26 bi-weekly survey waves (April 2020 - July 2021) and nine additional monthly follow-up surveys (October 2021 - June 2022), this study aims to investigate short- and long-term prospective associations of time-varying nicotine vaping with time-lagged smoking abstinences in follow-up extending up to 110 weeks after baseline as well as mediational effects of anxiety/depression symptoms on vaping-related smoking cessation. The proposed study will address the fundamental questions of whether vaping encourages smokers to initiate and sustain smoking cessation in the real world, and if they experience cessation-related mental health benefits.

PI_NAMEs: CHO, JUNHAN ;LEVENTHAL, ADAM MATTHEW (contact)

PROJECT_TERMS: Abstinence;Address;Adult;Alcohols;Anxiety;anxiety reduction;anxiety symptoms;Cannabis;Coronavirus;Costs and Benefits;Data;Data Sources;depressive symptoms;Development;Devices;drinking;Drug usage;Electronic cigarette;Equity;experience;Face;follow-up;Frequencies;Future;Goals;hazard;Health Benefit;Household;Illicit Drugs;Intake;Internet;long term abstinence;Longitudinal cohort;Longitudinal Studies;Measures;Mediating;Mediation;Mediator;Mental Depression;Mental Health;Modeling;Moods;Motivation;multilevel analysis;Negative Reinforcements;Nicotine;Nicotine Dependence;nicotine inhalation;novel;Observational Study;Outcome;pandemic impact;Paper;Pathway interactions;Persons;Policies;Population;Probability;prospective;Public Health;recruit;Regulation;Reporting;Research;Respondent;Sampling;Science;secondary analysis;Selection Bias;Smoke;Smoker;Smoking;smoking abstinence;smoking cessation;smoking relapse;sociodemographic factors;substance use;Surveys;Symptoms;Techniques;Testing;Time;vaping;vaping nicotine

PROJECT_TITLE: Vaping and Smoking Cessation in Intensive Longitudinal National Data


ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: P50 Narrative PD: Pascual, V. The Weill Cornell/JAX-GM Cooperative Center of Research Translation entitled “Center for Lupus Research” (CRL) aims i) to advance the knowledge of pathways that contribute to the establishment and amplification of Systemic Lupus Erythematosus (SLE), ii) to identify molecular mechanisms responsible for the failure to respond to standard of care (SOC) therapies, and iii) to develop assays and tools to monitor these dysfunctional pathways. Novel genomic technologies and bioinformatic resources will be used towards these goals, which will advance clinical trial design and ultimately personalized patient care.

PI_NAMEs: PASCUAL, MARIA VIRGINIA (contact)

PROGRAM_OFFICER_NAME: GREEN PARKER, MELISSA C

PROJECT_TERMS: Adult;Autoimmune Diseases;autoinflammatory diseases;bioinformatics resource;Biological Assay;Biological Markers;Biology;biomarker identification;Cells;Center for Translational Science Activities;Child;Child Health;Childhood;Clinical;Clinical assessments;Clinical Data;Clinical Trials Design;cohort;Collaborations;Communication;computer scientist;Data;Data Collection;Disease;Disease remission;Ensure;epigenetic profiling;epigenomics;Erythrocytes;Erythroid;Erythroid Cells;Failure;Flare;functional genomics;Gene Expression Profiling;Generations;Genetic Transcription;Genomics;Goals;Heterogeneity;Human;Immune;Immune system;Immunology;Inflammasome;Inflammatory;Infrastructure;Institution;Interferons;Knowledge;Laboratories;Letters;Lupus;Medicine;member;Mitochondria;Molecular;Monitor;Myeloid Cell Activation;Myeloid Cells;new therapeutic target;New York;next generation;novel;Nucleic Acids;participant enrollment;Pathogenicity;Pathway interactions;patient stratification;Patients;personalized care;personalized medicine;Phenotype;Plasmablast;programs;Protein Isoforms;Recording of previous events;Research;Research Personnel;Resistance;Resources;response;Role;Sampling;Scientist;Severity of illness;Source;Spliced Genes;standard of care;stem;Stratification;System;Systemic Lupus Erythematosus;Technology;therapy resistant;tool;treatment response;Variant;Work

PROJECT_TITLE: Center for Lupus Research


NIH_SPENDING_CATS: Autoimmune Disease;Lupus

PROJECT_TERMS: Administrator;Adult;Advisory Committees;Area;Center for Translational Science Activities;Childhood;Clinical;collaborative environment;Communication;Data;data sharing;Doctor of Philosophy;Ensure;experience;Fostering;General Population;Goals;Human;human subject;Infrastructure;Intellectual Property;Leadership;Lupus;meetings;Monitor;multidisciplinary;patient population;Patients;programs;Progress Reports;Recommendation;Research;Research Personnel;Resource Allocation;Resource Sharing;Sampling;Site;success;symposium;Systemic Lupus Erythematosus;United States National Institutes of Health;Virginia

PROJECT_TITLE: Admin Core


PROJECT_TERMS: Adult;Applications Grants;Automobile Driving;base;Blood specimen;Child Health;Childhood;Clinic;Clinical;Clinical assessments;Clinical Data;Collaborations;comorbidity;Correlative Study;Data;data acquisition;Diagnosis;Disease;Disease remission;Ensure;epigenomics;Flare;Future;Genomic medicine;Genomics;Goals;Immunologics;Infrastructure;Institution;Laboratories;Laboratory Research;Life;Lupus;Medical center;Medicine;Mission;Molecular;Monitor;Ohio;participant enrollment;Pathway interactions;Patients;Pediatric Hospitals;pediatric patients;personalized approach;Phenotype;programs;repository;Research;Research Personnel;Resources;Rheumatology;sample collection;Sampling;Scientist;sound;Source;Systemic Lupus Erythematosus;Technology;The Jackson Laboratory;Time;Universities;Work

PROJECT_TITLE: Clinical Core


PROJECT_TERMS: adaptive immunity;Address;Adult;Affect;Antibodies;Antigen-Antibody Complex;Autoantibodies;B-Lymphocytes;Biological Markers;Blood;Cells;Childhood;Clinical;clinical phenotype;Clinical Trials;Complement;Complex;cytokine;cytosolic receptor;Data;Degradation Pathway;Dendritic cell activation;Dendritic Cells;Development;Disease remission;Dissection;Endosomes;Environmental Risk Factor;Epigenetic Process;Erythrocytes;Erythroid;Erythroid Cells;Erythropoiesis;Event;Excision;Failure;Flare;Functional disorder;Gene Expression Profile;Gene Expression Profiling;Genes;Genetic;Genetic study;Genetic Transcription;genome wide association study;Glycolysis;Goals;Helper-Inducer T-Lymphocyte;Heterogeneity;Human;Immune system;Immunologic Monitoring;improved;In Vitro;Inflammasome;Inflammation;Inflammatory;Interferon Type I;Interferons;Link;Lupus;Maps;Measures;Metabolic;Minor;Mitochondria;Molecular;multicatalytic endopeptidase complex;Mutation;Myelogenous;Myeloid Cell Activation;Myeloid Cells;Natural Immunity;neutrophil;new therapeutic target;novel;novel marker;novel therapeutic intervention;Nuclear Antigens;Nucleic Acid Regulatory Sequences;Organ;Pathogenesis;Pathogenicity;Pathway interactions;patient stratification;Patients;Pediatric cohort;Peripheral Blood Mononuclear Cell;Phagocytes;Phase III Clinical Trials;Plasmablast;Play;Population;Prevalence;prevent;Production;progenitor;Pronormoblasts;Research;Resources;response;Role;Signal Transduction;single-cell RNA sequencing;Specificity;Subgroup;System;Systemic Lupus Erythematosus;Technology;tool;Transcript;Ubiquitin

PROJECT_TITLE: Project #1 Pascual


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Clinical Research;Genetics;Human Genome;Lupus

PROJECT_TERMS: 3-Dimensional;Affect;Antibodies;ATAC-seq;B-Lymphocytes;Biological;Biological Assay;Blood specimen;candidate validation;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cell Differentiation process;cell growth;Cell Nucleus;Cell surface;Cell Surface Proteins;cell type;Cells;Childhood;Chromatin;Clinical Management;cohort;CRISPR/Cas technology;Data;Dendritic Cells;Diagnosis;differentiation protocol;Disease;effective therapy;Enhancers;Epigenetic Process;epigenetic profiling;epigenome;epigenomics;Etiology;Exhibits;Flare;functional genomics;Funding;Gene Expression Profile;Gene Expression Profiling;Genes;genetic signature;Genetic Transcription;Genomic approach;genomic signature;Glucocorticoids;Goals;Growth;Helper-Inducer T-Lymphocyte;Hydroxychloroquine;Immune;immune function;improved;In Vitro;indexing;Individual;Interferons;Knock-out;Link;Longitudinal cohort;Lupus;Maps;Mediator;Molecular;monocyte;Morbidity - disease rate;multicatalytic endopeptidase complex;mycophenolate mofetil;new therapeutic target;Onset of illness;overexpression;Pathway interactions;Patients;Peripheral Blood Mononuclear Cell;Phenotype;Plasma Cells;Plasmablast;Population;programs;Protein Isoforms;Quantitative Trait Loci;Refractory;Regulatory Element;Relapse;Research;Resistance;resistance mechanism;response;RNA Splicing;Role;sample collection;Sampling;Severity of illness;Signal Transduction;single-cell RNA sequencing;standard of care;Systemic Lupus Erythematosus;T-Lymphocyte Subsets;Technology;Therapeutic Intervention;therapy resistant;Time;transcription factor;transcriptome;transcriptome sequencing;treatment response

PROJECT_TITLE: Project #2 - Banchereau


NIH_SPENDING_CATS: Kidney Disease

ORG_CITY: BIRMINGHAM

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE Acute Kidney Injury (AKI) is a serious clinical problem that affects ~20% of hospitalized patients and 60% of critically ill patients while increasing risk of developing chronic kidney disease. The overall goal of this project is to understand cellular and molecular mechanisms that govern how kidney resident macrophages (KRMs) maintain and restore renal function after injury. Understanding the involvement of the various KRM subpopulations and of C1q, one of the most abundant proteins produced by KRMs, will have a significant impact on our understanding of mechanisms that can be targeted for the treatment of AKI.

PI_NAMEs: CHEUNG, MATTHEW DAVID (contact)

PROGRAM_OFFICER_NAME: MARIC-BILKAN, CHRISTINE

PROJECT_TERMS: Acute Renal Failure with Renal Papillary Necrosis;Affect;Anatomy;Apoptotic;Area;Automobile Driving;Bilateral;Binding;Bioinformatics;career;career development;cell injury;Cells;Characteristics;Chronic Kidney Failure;Classical Complement Pathway;Clinical;clinical application;Communication;Complement;Complement 1q;complement system;Complication;Critical Illness;cytokine;Data;Death Rate;Dendritic Cells;Development;diphtheria toxin receptor;Doctor of Philosophy;Embryonic Development;End stage renal failure;Epithelial Cells;Evaluation;experience;experimental study;Familiarity;Frequencies;Functional disorder;Future;Genes;Genetic Transcription;Goals;Grant;healing;Health;Health Care Costs;Homeostasis;Hospitalization;Human;Immune;Immunologics;Immunology;immunoregulation;In Vitro;in vivo;inducible Cre;Infiltration;inhibitor;Injury;Injury to Kidney;Innate Immune System;Kidney;Kidney Diseases;Literature;Macrophage;Maintenance;Manuscripts;Mediating;Mediator;Mentors;Methods;migration;Modeling;Molecular;monocyte;Mononuclear;Morbidity - disease rate;mortality;mouse model;Mus;Nephrology;next generation sequencing;Ontology;Pathogenesis;Patients;Pattern Recognition;Phagocytes;Phagocytosis;Phosphatidylserines;Physicians;Play;Population;precision medicine;prevent;Process;Production;programs;Protein Tyrosine Kinase;Proteins;Reaction;receptor;Recombinants;Recovery;Renal function;Reperfusion Injury;Research;research and development;response;response to injury;responsible research conduct;Risk;RNA;Role;Scientist;self-renewal;single-cell RNA sequencing;skill acquisition;skills;Tamoxifen;targeted treatment;Testing;Tissue-Specific Gene Expression;Training;transcriptomics;Translational Research;United States National Institutes of Health;unsupervised clustering;uptake;Writing

PROJECT_TITLE: Response of kidney resident macrophages to proximal tubule injury


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Complementary and Integrative Health;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: La Jolla

ORG_NAME: SALK INSTITUTE FOR BIOLOGICAL STUDIES

PHR: PROJECT NARRATIVE In recent years, neuroscientists have increasingly come to appreciate the importance of understanding how the spatiotemporal organization of large-scale neural activity patterns influences perception, cognition, and motor control. Our project focuses on intrinsic traveling voltage waves (iTWs) in the mouse and marmoset sensory neocortex, how these waves may influence perceptual sensitivity and mammalian visual behavior, and the contributions of specific cortical neuron-types to these phenomena. To examine these issues, our research team comprises experts in visual neurophysiology and behavior, inventors of novel optical voltage-imaging and electrophysiological recording techniques, data scientists innovating advanced statistical analysis methods, and computational neuroscientists whose models of iTWs provide specific predictions that we will test empirically in mice and marmosets performing a visual detection task.

PI_NAMEs: COLEMAN, TODD P;KUZUM, DUYGU ;MULLER, LYLE EDWARD;REYNOLDS, JOHN H (contact);SCHNITZER, MARK J

PROGRAM_OFFICER_NAME: DAVID, KAREN KATE

PROJECT_TERMS: adjudication;Affect;Anatomy;Animals;Area;area MT;awake;Behavior;Brain;brain research;brain shape;Callithrix;cell type;Cells;Cognition;Cognitive;Color;Communication;Custom;Data;Data Scientist;Detection;Dorsal;Electrocorticogram;Electrodes;Electrophysiology (science);empowerment;Equilibrium;experimental study;extrastriate visual cortex;Fiber;Fluorescence;Future;Goals;Image;imaging approach;imaging study;improved;innovation;insight;Interneurons;invention;Kinetics;Learning;Link;Measurement;Measures;Methods;Modeling;Monkeys;motor behavior;motor control;Mus;Nature;Neocortex;neocortical;network models;neural;neural patterning;neuroimaging;Neurons;neurophysiology;Neurosciences;Neurosciences Research;neurotransmission;new technology;nonhuman primate;novel;optical imaging;Optics;Outcome;Pattern;Perception;Population;Process;Research;Resolution;response;retinotopic;Role;Scientist;Sensory;Signal Transduction;spatiotemporal;Statistical Data Interpretation;Stimulus;Structure;Surface;Syncope;System;Techniques;temporal measurement;Testing;Theoretical model;tool;Travel;Visual;Visual Cortex;Visual Perception;visual stimulus;voltage;voltage sensitive dye

PROJECT_TITLE: Traveling waves in neocortical circuits: Mechanisms, computational roles in sensory processing, and impact on sensory perception


NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Genetics;Human Genome;Immunotherapy;Macular Degeneration;Neurodegenerative;Neurosciences;Nutrition

PHR: PROJECT NARRATIVE  Age-related macular degeneration (AMD) is the leading cause of central vision loss in individuals 60 and older. Yet, the disease mechanisms underlying loss of lipid homeostasis and inflammation in the RPE/choroid remain elusive. In this proposal, we will define key molecular mechanisms by which choroidal macrophages influence lipid metabolism, immunomodulation, and neovascularization in the RPE/choroid during AMD pathogenesis.

PI_NAMEs: FORTMANN, SETH D (contact)

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: Acceleration;Adipose tissue;Age;Age related macular degeneration;Age Years;Alzheimer's Disease;American;Anatomy;Anti-Inflammatory Agents;Area;Atherosclerosis;Basement membrane;Bioinformatics;Blindness;Blood Vessels;career;Cells;Cessation of life;Choroid;Choroidal Neovascularization;Chronic;chronic inflammatory disease;Clinic;Clinical;Collaborations;Competence;Data;density;Deposition;design;Disease;disorder of macula of retina;Down-Regulation;Drusen;Ecosystem;Elderly;Enzyme-Linked Immunosorbent Assay;Evaluation;ex vivo imaging;Excision;experience;extracellular;Exudative age-related macular degeneration;Eye;Fatty Liver;FDA approved;Flow Cytometry;Foundations;fovea centralis;Functional disorder;Genes;Genetic Polymorphism;genetic risk factor;Goals;Grant;Health;health assessment;High Fat Diet;Histologic;Homeostasis;Human;human imaging;imaging study;Immune;Immunohistochemistry;immunoregulation;Immunosuppression;in vivo imaging;Individual;Inflammation;Inflammation Mediators;Interleukin-1 beta;Knockout Mice;Lasers;Lipid Binding;lipid metabolism;Lipids;Lipoproteins;Location;Macrophage;macula;Maintenance;Malignant Neoplasms;Mediating;Membrane;Mentors;Microglia;Modeling;Molecular;Morphology;Mus;Myeloid Cells;neovascular;neovascularization;neural;Neurodegenerative Disorders;new therapeutic target;Nonexudative age-related macular degeneration;novel;Obesity;Ophthalmologist;Oral;p65;Pathogenesis;Pathway interactions;Patients;Pericytes;Peripheral;Phagocytes;Phagocytosis;Pharmaceutical Preparations;Phase I Clinical Trials;Photoreceptors;Physicians;Play;Population;Primary Cell Cultures;receptor binding;Relative Risks;Research;Research Proposals;response;responsible research conduct;Retina;Risk Factors;Role;Safety;Sampling;Scientist;Senile Plaques;serial imaging;Signal Transduction;single-cell RNA sequencing;Stains;Structure of retinal pigment epithelium;Techniques;Testing;Therapeutic;Tissue Donors;tissue repair;Tissues;TNF gene;Training;transcriptome;transcriptome sequencing;transcriptomics;translational study;TREM2 gene;Tumor-associated macrophages;uptake;Vision;Writing

PROJECT_TITLE: Role of choroidal macrophages in regulating lipid homeostasis and immunosuppression of the RPE/choroid


NIH_SPENDING_CATS: Biomedical Imaging;Cardiovascular;Clinical Research;Heart Disease;Lung;Physical Activity;Prevention

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: Project Narrative Heart failure with preserved ejection fraction (HFpEF) is an increasingly common cardiovascular disease that significantly impairs physical abilities and has a poor long-term survival. As HFpEF is challenging to diagnose non-invasively and has no effective treatment strategies, this study seeks to use a novel cardiopulmonary exercise MRI protocol, involving supine ergometry, to accurately diagnose early stages of HFpEF and identify specific markers to better understand HFpEF progression and predict adverse cardiovascular health outcomes. The information gained from this study will improve diagnosis and prognosis for patients with HFpEF and eliminate the need for invasive hemodynamic cardiopulmonary exercise testing (iCPET), which is the current more costly, risky, and invasive diagnostic testing method.

PI_NAMEs: NEZAFAT, REZA  (contact)

PROGRAM_OFFICER_NAME: TINSLEY, EMILY

PROJECT_TERMS: accurate diagnosis;accurate diagnostics;Acute;Aorta;Biological Markers;Blood Vessels;Brain natriuretic peptide;Breathing;Cardiac;Cardiopulmonary;Cardiovascular Diseases;cardiovascular health;cardiovascular risk factor;Cardiovascular system;Cessation of life;Clinical;Clinical Trials;comorbidity;Complex;Coronary;cost;Data;Dedications;Diagnosis;Diagnostic;diagnostic criteria;Diagnostic Specificity;Diagnostic tests;Disease Outcome;Disease Progression;Dyspnea;Early Diagnosis;Early Intervention;effective therapy;EFRAC;Ergometry;Etiology;Evaluation;Exercise;exercise intolerance;Exercise Test;Exertion;experience;Fatty acid glycerol esters;follow-up;Functional disorder;Functional impairment;Goals;Health;Heart;Heart Abnormalities;Heart failure;heart failure with reduced ejection fraction;heart imaging;hemodynamics;Hospitalization;Image;Imaging Device;improved;innovation;insight;Life;Lung;Lung Diseases;lung imaging;Magnetic Resonance Imaging;Measures;Medical center;Medicine;Methods;Monitor;Morbidity - disease rate;mortality;MRI Scans;Myocardial tissue;Nature;new epidemic;non-invasive imaging;noninvasive diagnosis;novel;novel strategies;novel therapeutic intervention;novel therapeutics;Obesity;Organ;Outcome;Outpatients;patient prognosis;Patient Recruitments;Patients;Performance;pharmacologic;Phenotype;physical impairment;Physiological;Plasma;preservation;Prevalence;prevent;Preventive care;Probability;Prognosis;prognostic;prohormone;Prospective Studies;Protocols documentation;Pulmonary Edema;pulmonary symptom;Pulmonary Ventilation;Reference Standards;Resistance;response;Rest;Risk;Role;serial imaging;Signs and Symptoms;Specialized Center;Stress;stressor;Structure;Supination;Symptoms;Syndrome;Technology;Testing;Time;treatment strategy;United States;vascular abnormality;Vasodilator Agents;Ventricular

PROJECT_TITLE: Cardiopulmonary Exercise MRI in Heart Failure with Preserved Ejection Fraction


PHR: Public Health Relevance Statement: This proposal will address a pressing public health concern, namely, the epidemic of ‘youth’ vaping. The studies described in this proposal will investigate the largely unknown health consequences of youth vaping by measuring molecular changes linked to risk of disease in tissues and cells of healthy youth who are regular users of electronic cigarettes (e-cigs). The findings of this project are expected to be of immediate use for the regulatory agencies who are in urgent need of scientific evidence informing the regulation of the manufacture, distribution, and marketing of e-cigs to protect youth and promote public health.

PI_NAMEs: BESARATINIA, AHMAD  (contact)

PROJECT_TERMS: Address;Algorithms;Area;Biochemical;Biological;Biological Markers;Biological Specimen Banks;California;Carcinogens;Cells;Characteristics;Collaborations;Collection;Computer Models;Data;Data Set;demographics;Development;Devices;Diet;Disease;disorder risk;Dose;e-cigarette aerosols;Electronic cigarette;electronic cigarette use;electronic cigarette user;electronic liquid;Epidemic;Epigenetic Process;Funding;Gene Expression;Gene Expression Profiling;Gene Expression Regulation;Generations;Genes;Genetic Transcription;Health;health assessment;innovation;interest;Laboratories;Leukocytes;Life Style;Link;manufacture;Marketing;Measurement;Measures;Mediating;Methods;Modeling;Molecular;National Institute of Dental and Craniofacial Research;Network-based;Nicotine;novel marker;Oral;Pathway Analysis;peripheral blood;Population;preservation;Process;Public Health;public health relevance;public repository;recruit;Regulation;Regulator Genes;Risk;Risk Assessment;Sampling;Smoking Status;Source;Special Population;Specimen;Study Subject;Systems Biology;Tissue-Specific Gene Expression;Tissues;tobacco products;tobacco regulation;toxicant;transcriptome sequencing;Untranslated RNA;vaper;vaping;Vulnerable Populations;Walking;Youth

PROJECT_TITLE: Network-based analysis of disease-associated epigenetic changes in youth electronic cigarette users


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

ORG_CITY: CORAL GABLES

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

PHR: Project Narrative This program will prepare the next generation of scientists, medical doctors, and future leaders to solve the most pressing health issues within our diverse community. In this program, 10 young scholars will receive two years of in-depth training and guidance from experienced scientists, physicians and community mentors who will help them become outstanding independent researchers. This program is designed to meet the national need of increasing the number of scientists from diverse backgrounds to better reflect and serve our communities.

PI_NAMEs: FORNONI, ALESSIA ;RUNDEK, TATJANA  (contact)

PROGRAM_OFFICER_NAME: LEYVA, FRANCISCO

PROJECT_TERMS: Acceleration;Address;Area;career;career development;Clinical;Clinical Sciences;clinical translation;Collaborations;Communication;Communities;Community Health;Competence;Complex;design;Discipline;Disparity;Dissemination and Implementation;Diverse Workforce;Doctor of Philosophy;Effectiveness;Environment;equity, diversity, and inclusion;ethnic identity;Evaluation;experience;Funding;Geographic Locations;Goals;health disparity;health equity;Institution;Knowledge;Laboratories;Lead;Mentored Clinical Scientist Development Program;mentoring community;Mentors;Mentorship;multidisciplinary;National Center for Advancing Translational Sciences;Patients;peer;population health;Program Development;Program Evaluation;programs;Public Health;Qualifying;Race;recruit;Research;Research Personnel;Research Training;Science;Scientist;systems research;Training;training opportunity;Training Programs;Translation Process;Translational Research;translational scientist;Universities;Vision

PROJECT_TITLE: Miami Clinical and Translational Science Institute K12 Program


NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Genetics;Human Genome;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: NARRATIVE Primary open-angle glaucoma (POAG) is a common optic nerve disease for which clinical risk factors (such as high intraocular pressure) and therapies (such as pressure lowering drugs) have been evaluated by NIH- funded studies, such as the Ocular Hypertension Treatment Study (OHTS). In this research project, we will analyze clinical and genome-wide-association study data from the OHTS cohort to create a risk calculator for incident POAG as well as to identify genetic risk factors for rapidly progressing POAG. We will also investigate the function of top POAG genetic risk factors to identify how they specifically promote disease, which will reveal disease mechanisms; identify relevant biological pathways; and inform development of future therapies.

PI_NAMEs: FINGERT, JOHN H (contact);GORDON, MAE O;SCHEETZ, TODD E

PROGRAM_OFFICER_NAME: SONG, HONGMAN

PROJECT_TERMS: ADAMTS;Alleles;Biological;Biology;Bite;Blindness;Caring;cell type;Cells;Clinical;Clinical Data;clinical risk;cohort;Cohort Studies;Collection;Data;Data Set;design;Development;diagnostic tool;Disease;Disease Progression;disorder risk;Dissociation;empowerment;Enrollment;Enzyme-Linked Immunosorbent Assay;Epidemiology;Eye;Familiarity;field study;Funding;Future;GABA Receptor;gene discovery;Gene Expression;Genes;Genetic;Genetic Research;genetic risk factor;Genetic study;Genome;genome wide association study;Genotype;Glaucoma;Goals;hazard;high intraocular pressure;Human;hypertension treatment;Immunohistochemistry;improved;insight;Iowa;Lead;Learning;Linkage Disequilibrium;Measures;Molecular;new therapeutic target;novel therapeutics;Ocular Hypertension;Optic Disk;optic nerve disorder;optical disc;Participant;Pathway interactions;Patient Care;Patient risk;Patients;personalized diagnostics;Persons;Pharmaceutical Preparations;phenotypic data;Physiologic Intraocular Pressure;pressure;prevent;Primary Open Angle Glaucoma;Probability;prognostic tool;prospective;Proteins;Protocols documentation;Reading;Receptor Gene;Research Project Grants;Resources;Retina;Retinal Ganglion Cells;Risk;Risk Factors;Risk Reduction;risk variant;screening;Single Nucleotide Polymorphism;single-cell RNA sequencing;Source;Technology;Testing;Tissues;tool;Transcriptional Regulation;Translating;translational study;United States National Institutes of Health;Validation;validation studies;Variant;Vision;Visual Fields;Visual impairment

PROJECT_TITLE: Genetic Factors for Glaucoma in the OHTS; Risk, Progression and Mechanism

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]


ED_INST_TYPE: SCHOOLS OF NURSING

ORG_CITY: TALLAHASSEE

ORG_NAME: FLORIDA STATE UNIVERSITY

PHR: PROJECT NARRATIVE  FSU aims to develop, implement, and evaluate a program, Fostering Institutional Resources for Science Transformation: The FLORIDA-FIRST Health-Science Brigade (aka The FLORIDA-FIRST Brigade), to transform culture at FSU to generate a self-sustaining scientific community dedicated to diversity, equity, and inclusive excellence. We propose leveraging institutional resources to recruit a FIRST Cohort of 6 early-career, URM biomedical researchers who demonstrate a commitment to diversity and inclusive excellence and who contribute to clusters of research excellence in chronic disease prevention and management (Cluster 1) or mental health (Cluster 2) and to implement a systems-level approach and generate evidence of its effectiveness for supporting individual faculty research and career development (micro), within their cohort and collaborative networks (meso), that can be replicated through sustainable changes to university culture (macro).

PI_NAMEs: FLORES MILLENDER, EUGENIA ;KEEL, PAMELA K.;WONG, FRANK Y. (contact)

PROGRAM_OFFICER_NAME: HUSSAIN, SHADAB FATIMA

PROJECT_TERMS: Address;Advisory Committees;anti-racism;Appointment;Area;Articulation;Arts;Award;Calibration;career;career development;Chronic Disease;Clinical and Translational Science Awards;clinical translation;cohort;Collaborations;college;Communities;community building;Data;Dedications;design;Development;Development Plans;Discipline of Nursing;Disease Management;disorder prevention;diversity and inclusion;Education;Effectiveness;Ensure;Equity;equity, diversity, and inclusion;ethnic diversity;Evaluation;Evidence based practice;Faculty;Faculty Recruitment;faculty research;faculty support;Family;Florida;Fostering;Funding;Goals;Health;health science research;Health Sciences;improved;Individual;innovation;Institution;Institutional Practice;Investments;Leadership;Medicine;member;Mental Health;Mentors;Mentorship;Mission;model design;Modeling;next generation;Physicians;programs;Protocols documentation;racial diversity;recruit;Research;research and development;Research Personnel;Resources;response;Rewards;Rural Community;Science;Scientist;social;Strategic Planning;System;Teacher Professional Development;Testing;Training;Translational Research;Underrepresented Minority;United States National Institutes of Health;Universities


NIH_SPENDING_CATS: Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: WONG, FRANK Y. (contact)

PROJECT_TERMS: Address;Behavioral Sciences;biobehavior;cohort;Committee Members;Communication;Communities;community engagement;Data;design;Development;diversity and inclusion;Education;Effectiveness;Ensure;Equity;evidence base;Faculty;Family;Florida;Fostering;Funding;Goals;Health;health determinants;health equity;Health Sciences;Individual;Infrastructure;innovation;Institution;Institutional Practice;Intervention;Lead;Leadership;Marketing;Mentors;Mentorship;Minority;Mission;Modeling;next generation;population health;Population Sciences;Procedures;Program Development;programs;recruit;Research;Research Infrastructure;Resources;Science;social;sociocultural determinant;Strategic Planning;Structure;Systems Theory;Teacher Professional Development;Testing;translational pipeline;Translational Research;Universities;Workforce Development

PROJECT_TITLE: Fostering Institutional Resources for Science Transformation: The FLORIDA-FIRST Health-science Brigade

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-RPHB-Y]