ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: Decatur

ORG_NAME: VETERANS HEALTH ADMINISTRATION

ORG_STATE: GA

PHR: Every year approximately 15,000 Veterans are hospitalized for stroke, and up to 40% of those Veterans will experience stroke-related language impairment (i.e., aphasia). Stroke-induced aphasia results in increased healthcare costs and decreased quality of life. As our population of Veterans continues to age, there will be an increasing number for Veterans living with the aphasia and its consequences. Those Veterans deserve to receive aphasia treatment designed to facilitate the best possible outcomes. In the proposed study, we will investigate optimal treatment intensity and predictors of treatment response for a novel word retrieval treatment. The knowledge we gain will have direct implications for the selecting the right treatment approach for the right Veteran.

PI_NAMEs: RODRIGUEZ, AMY D (contact)

PROJECT_TERMS: Address;Adjuvant;Age;Anomia;Aphasia;aphasia rehabilitation;Behavior;Behavior assessment;Brain;Brain region;Chronic;Chronic Disease;Clinical;clinical decision-making;clinical practice;clinical translation;Cognitive;cognitive function;Computers;cost;Data;Development;Dose;experience;Family;follow-up;Frequencies;Gestures;Goals;Hand;Health Care Costs;health related quality of life;Healthcare Systems;Hospitalization;Image;image processing;Impairment;improved;Individual;Intention;Intervention;Knowledge;Language;language impairment;Learning;Left;Lesion;Location;Maintenance;Memory;military veteran;neural;neuroimaging;Neurologic;Neurophysiology - biologic function;novel;optimal treatments;Outcome;Participant;Patients;predicting response;Prediction of Response to Therapy;Quality of life;Research;Resources;response;Retrieval;Schedule;Service delivery model;Societies;Stroke;stroke-induced aphasia;telehealth;therapy design;Time;Training;Treatment Factor;treatment group;Treatment outcome;treatment response;trial comparing;verbal;Veterans;Word Processing;Work

PROJECT_TITLE: Intention Treatment for Anomia: Investigating Dose Frequency Effects and Predictors ofTreatment Response to Improve Efficacy and Clinical Translation

STUDY_SECTION_NAME: Sensory Systems & Communication Disorders[RRD3]


ADMINISTERING_IC: MH

ARRA_FUNDED: N

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences

ORG_CITY: CAMBRIDGE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: MISCELLANEOUS

ORG_FIPS: US

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

ORG_STATE: MA

PHR: Adapting behavior to learn, or to make correct decisions, is necessary for the survival as an individual or species as well as for ongoing maintenance of bodily and mental health. Our research is dedicated to identify fundamental functions of cortico-striato-dopaminergic circuits in adapting behavior during reinforcement learning and cost- benefit deliberations, especially when the learning efficacy or evaluation bias is tuned by instantaneous motivational state. We hope, and expect, that the findings of our research will contribute to the efforts in the field to alleviate sufferings of people, due to the maladaptive mood, motivation and cognition, as manifested in a variety of neuropsychiatric and neurodegenerative diseases.

PI_NAMEs: GRAYBIEL, ANN M (contact)

PROGRAM_OFFICER_NAME: RANGEL GOMEZ, MAURICIO

PROJECT_TERMS: Address;Affect;Anatomy;Animals;approach/avoidance behavior;Area;Automobile Driving;Axon;Back;Basal Ganglia;Behavior;Behavior assessment;Behavioral;Binding;Brain;Cells;Clinic;Cognition;conditioning;Corpus striatum structure;cost;Costs and Benefits;Cues;Date of birth;Decision Making;Dedications;Dendrimers;Dendrites;designer receptors exclusively activated by designer drugs;Desire for food;Discrimination;Dissociation;Dopamine;dopaminergic neuron;Environment;Equilibrium;Evaluation;Exhibits;Face;Fiber;Funding;Gene Expression Profile;Genetic;Goals;Head;Health;Human;Image;Individual;Knowledge;Label;Learning;Link;Maintenance;Measures;Mental disorders;Mental Health;Methods;Mission;Modeling;Moods;Motivation;Movement;Mus;National Institute of Mental Health;Negative Valence;Neocortex;Nervous System Disorder;Neurodegenerative Disorders;Neurons;neuropsychiatric disorder;neurotransmission;Output;Parkinson Disease;pars compacta;Pathway interactions;Pattern;Personal Satisfaction;Persons;Photometry;Positive Valence;prevent;Process;Psychological reinforcement;recruit;Research;Rewards;Role;Schedule;sensor;Signal Transduction;single nucleus RNA-sequencing;striosome;Substantia nigra structure;System;Testing;Tissue-Specific Gene Expression;tool;Training;two-photon;Viral;Work

PROJECT_TITLE: Functional and anatomical characterization of the striosomal system

STUDY_SECTION: SMN

STUDY_SECTION_NAME: Sensory-Motor Neuroscience Study Section[SMN]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Comparative Effectiveness Research;Hematology;Precision Medicine;Prevention;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_NAME: ECOG-ACRIN MEDICAL RESEARCH FOUNDATION

ORG_STATE: PA

PHR: Project Narrative The ECOG-ACRIN Central Biorepository and Pathology Facility (EA CBPF) will receive process, store and distribute high quality, well-annotated tissue specimens as well as blood and other biological fluids from patients participating in NCTN and NCORP clinical trials and assist NIH/NCI-supported specimen banking organizations. The specimens will encompass tumor and non-malignant tissue and cytology specimens, peripheral blood, bone marrow, and other fluid samples, from multiple tumor sites (e.g., tumors of the brain, breast, gastrointestinal tract, genitourinary tract, gynecologic/reproductive system, head and neck, skin, liver, lung, soft tissue, thyroid gland and other cancers) and hematologic malignancies (leukemia, lymphoma, and multiple myeloma and related diseases).

PI_NAMEs: HAMILTON, STANLEY R.;WISTUBA, IGNACIO I. (contact)

PROGRAM_OFFICER_NAME: MAKHLOUF, HALA

PROJECT_TERMS: advanced disease;American College of Radiology Imaging Network;Basic Science;biobank;Biological;Biological Markers;Biological Specimen Banks;biomarker driven;Biometry;Blood;Body Fluids;Bone Marrow;Boston;Brain Neoplasms;cancer care;Cancer Center;Cancer Patient;cancer prevention;Cancer Research Network;Catalogs;cell free DNA;Cells;Chicago;Clinic;Clinical;Clinical Research;Clinical Sciences;Clinical Treatment;Clinical Trials;clinically relevant;Collaborations;Collection;Colorado;Continuity of Patient Care;Correlative Study;Cytology;Dana-Farber Cancer Institute;Data;Data Coordinating Center;Databases;Department chair;Development;Disease;Doctor of Philosophy;Early Diagnosis;Eastern Cooperative Oncology Group;Ensure;exosome;Focus Groups;Funding;Future;Gastrointestinal Neoplasms;Goals;Gynecologic;Head;Head and neck structure;Hematologic Neoplasms;Human;Image;imaging science;Immunologic Monitoring;Immunologics;Information Technology;Infrastructure;innovation;Laboratories;leukemia;Link;Liquid substance;Liver;Lung;Lymphoma;Malignant - descriptor;Malignant Neoplasms;Mammary Neoplasms;Medicine;Methodology;Modification;Molecular;molecular pathology;Multiple Myeloma;National Clinical Trials Network;Neoplasm Circulating Cells;New York;Non-Malignant;novel;novel marker;operation;participant enrollment;Pathologic;Pathology;Patient Participation;Patients;Performance;peripheral blood;predictive marker;Principal Investigator;Process;Productivity;professor;programs;Proteins;Records;repository;Reproductive system;Research;Research Personnel;Resources;RNA;Sampling;Science;screening;Services;Site;Skin;soft tissue;Specimen;support network;Therapeutic;Thyroid Gland;Tissues;Translational Research;treatment and outcome;treatment trial;tumor;United States National Institutes of Health;Universities;University of Texas M D Anderson Cancer Center;urogenital tract

PROJECT_TITLE: ECOG-ACRIN Biospecimen Bank to Support NCTN


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Breastfeeding, Lactation and Breast Milk;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Regenerative Medicine

ORG_CITY: ATHENS

ORG_NAME: UNIVERSITY OF GEORGIA

PHR: Project Narrative Glycans play crucial roles in a wide range of biological functions, including critical roles as human milk oligosaccharides (HMOs) that protect from infection, maintain proper microbiota, and aid in infant development. The synthesis of complex HMOs is presently too costly for their widespread use. This project aims to develop an inexpensive, modular, and flexible synthesis strategy for enzymatic glycan assembly from simple building blocks as a proof-of-concept for scalable HMO synthesis that will expand their use as human therapeutics.

PI_NAMEs: MOREMEN, KELLEY W. (contact)

PROGRAM_OFFICER_NAME: CLARK, DAVID

PROJECT_TERMS: Address;Applications Grants;Automobile Driving;Biological;Biological Process;biological systems;Biology;catalyst;Chemicals;Complex;cost;Coupled;Couples;Coupling;Data;Development;Divalent Cations;Energy-Generating Resources;Enzyme Inhibition;Enzymes;flexibility;Future;Generations;Glycoconjugates;glycosylation;glycosyltransferase;Goals;Gut Mucosa;Human;human milk oligosaccharides;human model;Hypersensitivity;In Situ;Infant;Infant Development;Infant formula;Infection;Infection prevention;inorganic phosphate;interest;Ions;Lactose;Libraries;Lipids;Methods;microbiota;Monitor;Monosaccharides;Natural regeneration;Necrotizing Enterocolitis;Nucleic Acids;Nucleoside-Diphosphate Kinase;Nucleotide Biosynthesis;Nucleotides;Organism;Outcome;pathogen;Play;Polyphosphates;Polysaccharides;Premature Infant;prevent;Production;Proteins;Reaction;Reagent;Role;scale up;sialyl Lewis x;Source;Specificity;Structure;sugar;sugar nucleotide;Supplementation;System;targeted treatment;Testing;Therapeutic;therapeutic development;Therapeutic Studies;tool;virtual

PROJECT_TITLE: Economical Modular One-Pot Multienzyme Synthesis of Human Milk Oligosaccharides

STUDY_SECTION: SBCA

STUDY_SECTION_NAME: Synthetic and Biological Chemistry A Study Section[SBCA]


ORG_CITY: Aurora

ORG_NAME: VA EASTERN COLORADO HEALTH CARE SYSTEM

ORG_STATE: CO

PHR: This study will examine the impact of a new clinical decision support tool for rehabilitation after total knee arthroplasty (TKA). Typically, TKA rehabilitation is generic with most patients receiving the same dosage and contents of rehabilitation despite notable diversity among patients who undergo TKA. Our clinical support decision tool is designed to help physical therapists tailor rehabilitation treatments and dosages to the individual needs, goals, and preferences of Veterans recovering from TKA. This study has the potential to improve Veterans’ functional recovery after TKA, while simultaneously reducing the average number of physical therapy visits Veterans attend after surgery by tailoring rehabilitation dosage based upon need. This will ensure the Veterans Health Administration (VHA) has the resources and capacity to provide adequate rehabilitation to every Veteran seeking TKA in the VHA system. Additionally, if successful, this clinical decision support tool could be used to improve outcomes and access for additional patient populations in the future.

PI_NAMEs: STEVENS-LAPSLEY, JENNIFER E. (contact)

PROJECT_TERMS: Address;Affect;Ambulatory Care Facilities;barrier to care;Caring;Clinic;Clinical;clinical application;clinical decision support;clinical practice;cohort;comorbidity;Consensus;cost;Data;design;disability;dosage;Effectiveness;Ensure;expectation;Expenditure;Focus Groups;functional outcomes;Future;Goals;Guidelines;Health;Healthcare;Improve Access;improved;improved outcome;Individual;individual patient;individualized medicine;innovation;Knee Osteoarthritis;knee replacement arthroplasty;Lower Extremity;Methods;Monitor;Operative Surgical Procedures;Orthopedics;Outcome;Outpatients;Pain;Participant;patient oriented;patient population;Patient Self-Report;Patients;Persons;physical therapist;Physical therapy;point of care;Population;post-operative rehabilitation;Postoperative Care;Postoperative Period;predictive tools;preference;Procedures;Process;prospective;Readiness;Recommendation;Recovery;Recovery of Function;rehabilitation service;Rehabilitation therapy;Reporting;Resources;Risk;Services;Statistical Models;support tools;Surveys;System;Testing;tool;Translations;treatment strategy;usability;Veterans;Veterans Health Administration;Visit;Waiting Lists

PROJECT_TITLE: Improving Rehabilitation for Veterans After Total Knee Arthroplasty Using Individualized Recovery Trajectories

STUDY_SECTION_NAME: Musculoskeletal Health & Function[RRD2]


FUNDING_MECHANISM: OTHERS

ORG_CITY: BALTIMORE

ORG_NAME: BALTIMORE VA MEDICAL CENTER

ORG_STATE: MD

PHR: Chronic pain has a highly negative impact on Veterans, especially those with serious mental illness (SMI). Chronic pain leads to poorer mental health and physical functioning, and represents a critical obstacle to rehabilitation and recovery. Despite known high prevalence rates of chronic pain in SMI populations, there is little research to: a) evaluate nonpharmacological pain management strategies in this population, and b) examine directional relations between chronic pain and SMI symptoms. This study aims to address research and clinical gaps by: a) testing the feasibility and acceptability of Cognitive Behavioral Therapy for Chronic Pain (CBT-CP) - a VA evidence-based psychotherapy for chronic pain in Veterans with SMI, and b) better assessing the complex relation between chronic pain and psychiatric symptoms and their impact on functioning. Results from this study will inform us as to whether CBT-CP is feasible to implement, acceptable to Veterans with SMI, and worth examining in its standard or in an optimized form in a larger clinical trial.

PI_NAMEs: TRAVAGLINI, LETITIA  (contact)

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;Aftercare;Analgesics;Anxiety;Area;Behavior Therapy;Behavioral;Bipolar Disorder;career;career development;chronic musculoskeletal pain;chronic pain;chronic pain management;chronic painful condition;Clinical;Clinical Trials;Cognitive Therapy;Complex;Data;design;Development;Diagnosis;Disparity;Ecological momentary assessment;Employment;Evaluation;evidence base;Exclusion;experience;feasibility testing;follow-up;Functional impairment;functional improvement;functional outcomes;Future;General Population;Goals;Grain;Health;Healthcare;High Prevalence;Hospitalization;Impairment;improved;Individual;Intervention;Interview;K-Series Research Career Programs;Knowledge;Leadership;Learning;Link;Measures;Medical;Mental Depression;Mental Health;Mentors;Methods;Monitor;mood symptom;Nature;Nonpharmacologic Therapy;Opioid;Pain;Pain management;pain reduction;pain symptom;Participant;Patient Self-Report;Persons;Pharmaceutical Preparations;Physical activity;physical conditioning;Physical Function;Population;process evaluation;programs;psychiatric symptom;psychosocial;Psychotherapy;Quality of life;Questionnaires;Randomized;Randomized, Controlled Trials;Recovery;Recovery of Function;recruit;rehabilitation research;Rehabilitation therapy;Reporting;Research;research study;response;Risk;satisfaction;Schedule;Schizophrenia;schizophrenia spectrum disorder;Services;severe mental illness;Severities;skills;social;Specific qualifier value;standard of care;substance use;suicidal risk;Surveys;Symptoms;System;Telephone;Testing;Time;Training;Trauma;Veterans;Veterans Health Administration;Work

PROJECT_TITLE: Improving the Assessment and Treatment of Chronic Pain in Veterans with Serious Mental Illness

STUDY_SECTION_NAME: Career Development Program - Panel II[RRD9]


ORG_CITY: BOSTON

ORG_NAME: VA BOSTON HEALTH CARE SYSTEM

PHR: Project Narrative Damage to primary visual cortex and adjacent regions (area V1+) after stroke typically results in dense contralateral loss of vision, which can have devastating consequences for one’s quality of life. This is a common problem in the VA population. There are currently no effective methods to restore vision in subjects with dense visual field scotomas as a result of V1 lesions. The chief aims of our proposal are: 1) To use functional magnetic resonance imaging (fMRI) population receptive field analysis methods to identify regions of the visual field that have high potential for rehabilitation after lesions of the primary visual cortex. 2) To study how the strength of visual modulation in spared visual areas changes with rehabilitative training, and whether observed changes correlate with recovery. This will be a first step towards our long-term goal, which is to develop a rational, fMRI based, approach to visual rehabilitation following cortical lesions.

PI_NAMEs: SMIRNAKIS, STELIOS MANOLIS (contact)

PROJECT_TERMS: Activities of Daily Living;Address;Adverse effects;Area;area striata;area V1;Attention;Behavioral;Blindness;Brain;clinically significant;Contralateral;cooking;Data;design;discrimination task;dysphoria;Environment;experience;extrastriate;extrastriate visual cortex;Feeling;Feeling suicidal;Functional Magnetic Resonance Imaging;Goals;Health;Hemianopsia;Homonymous Hemianopia;Human;Impairment;improved;information processing;Injury;Learning;Lesion;Libraries;Maps;Measurement;Measures;Mediating;Methods;Middle Cerebral Artery Infarction;Minor;Motion Perception;Neurosciences;Noise;Optics;Pathway interactions;Patients;Performance;Perimetry;Population;population based;post stroke;Primary Lesion;Quality of life;Radiation;receptive field;Recovery;Rehabilitation therapy;Reporting;Residual state;Resistance;response;Scotoma;sight restoration;Signal Transduction;Son;Stimulus;Stroke;stroke survivor;Testing;Training;Veterans;Vision;Visual;Visual Cortex;Visual disability;Visual Fields;Visual impairment;visual information;Visual Motion;Visual Pathways;Visual Perception;visual performance;visual processing;Work

PROJECT_TITLE: Developing a rational strategy for visual rehabilitation after cortical lesions

STUDY_SECTION_NAME: Brain Health and Injury[RRD1]


ORG_CITY: SAN DIEGO

ORG_NAME: VA SAN DIEGO HEALTHCARE SYSTEM

ORG_STATE: CA

PHR: Access to a flexible spectrum of family-based VA mental health care for Veterans is mandated by law. Research shows that relationship distress harms Veterans’ mental health, physical health, and mortality, while healthy relationships provide resilience and facilitate recovery from illness. However, there are many barriers to accessing couple and family care within VA, including system-level barriers such as insufficient access to specialty providers and couple-level barriers such as difficulty coordinating schedules and finding childcare. OurRelationship is an evidence-based, coached online intervention for couples that provides flexible, accessible, and scalable treatment to improve relationship functioning. This proposed CDA-2 project will test whether OurRelationship is effective for improving Veterans’ intimate relationships and supporting their rehabilitation. This study supports the mission of the 2018-2024 Strategic Plan of the Department of Veterans Affairs by improving Veterans’ relationship functioning to enhance their overall quality of life.

PI_NAMEs: KNOPP, KAYLA  (contact)

PROJECT_TERMS: acceptability and feasibility;Address;Anxiety;Area;Award;Behavior;Behavioral;behavioral health;biopsychosocial;cardiovascular risk factor;career;career development;Caring;Child Care;Clinic;Clinical;Clinical Trials;Clinical Trials Design;clinically significant;Communication;Communities;Competence;Conflict (Psychology);Couples;Couples Therapy;Data;Development;Development Plans;Diagnostic;digital;digital health;digital healthcare;digital intervention;Distress;Divorce;efficacy evaluation;evidence base;experience;Face;Family;Feedback;Feeling suicidal;flexibility;follow-up;functional disability;functional improvement;Goals;Health;health assessment;health care availability;Health Services Accessibility;Health Technology;Healthcare Systems;Hour;Impairment;improved;Individual;Intervention;Interview;intimate partner violence;K-Series Research Career Programs;Knowledge;Laws;Location;Mediation;Medical center;medical specialties;Mental Depression;Mental Health;Mental Health Services;Mentors;Mentorship;Methodology;Methods;military veteran;Mission;Modeling;mortality;online intervention;Outcome;Participant;physical conditioning;pilot test;post intervention;primary outcome;Problem Solving;programs;Protocols documentation;Provider;psychiatric symptom;Psychology;Psychotherapy;Quality of life;Randomized Controlled Clinical Trials;Recovery;recruit;Rehabilitation Outcome;Rehabilitation therapy;Reporting;Research;Research Personnel;resilience;Risk;Role;Sampling;satisfaction;Schedule;secondary analysis;skills;social;Social Functioning;social stigma;Strategic Planning;Stress;stressor;Structure;Suicide attempt;System;system-level barriers;Technology;telehealth;Testing;theories;Therapeutic;Time;Training;Trauma;United States Department of Veterans Affairs;Veterans;Waiting Lists;Work

PROJECT_TITLE: Clinical Trial of OurRelationship, a Scalable Digital Intervention for Veteran Couples


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology;Immunotherapy

ORG_CITY: NOTRE DAME

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF NOTRE DAME

ORG_STATE: IN

PHR: Narrative This project studies the structural biophysics of molecular recognition in the immune system, emphasizing T cell receptors and peptide/MHC proteins. These complex interactions are central to the form and function of the immune system. Moreover, they serve as model systems for complex molecular interactions that occur throughout biology.

PI_NAMEs: BAKER, BRIAN M (contact)

PROGRAM_OFFICER_NAME: CHAO, CHIEN-CHUNG

PROJECT_TERMS: Address;Behavior;Binding;Biochemistry;Biological Models;Biology;Biophysics;Cell Signaling Process;Cellular Immunity;Cellular Immunology;Complex;cross reactivity;design;Elements;Engineered Gene;engineered T cells;Funding;Goals;Immune;Immune response;Immune system;immune system function;immunogenicity;Immunology;Immunotherapy;improved;insight;Instruction;Learning;lens;Ligands;MHC Interaction;Modeling;Molecular;Molecular Immunology;molecular recognition;National Institute of General Medical Sciences;new growth;novel therapeutic intervention;Outcome;peptide based vaccine;Peptide Receptor;Peptide/MHC Complex;Peptides;Physical Chemistry;Process;Property;Protein Dynamics;Proteins;receptor;Research;Signal Transduction;Specificity;structural biology;success;System;T-Cell Receptor;T-Lymphocyte;Work

PROJECT_TITLE: Structural biophysics and molecular design in cellular immunity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-V(55)R]


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Obesity;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Within adipose tissues reside adipocytes with divergent functions, including distinct adipocytes that favor energy storage and others that dissipate energy. The balance of these different types of adipocytes has broad implication for metabolism and general health. This project is aimed at elucidating the pathways and unraveling the molecular mechanisms that distinguish the formation of different types of adipocytes.

PI_NAMEs: FELDMAN, BRIAN J (contact)

PROGRAM_OFFICER_NAME: HAFT, CAROL R

PROJECT_TERMS: Adipocytes;adipose derived stem cell;Adipose tissue;Biology;Categories;cell type;Cellular biology;Classification;Data;Development;Diet;Elements;Environment;Equilibrium;expectation;Exposure to;Family member;Foundations;Generations;Genes;Goals;Health;Heterogeneity;hormonal signals;Hormones;Individual;Knowledge;Lipids;Mammals;Metabolic;Metabolic Diseases;Metabolism;Molecular;Molecular Biology;mouse model;novel therapeutic intervention;Obesity;Pathway interactions;Physiological;Process;programs;Property;public health relevance;response;Rodent;Role;Signal Transduction;stem cell population;stem cells;Stimulus;subcutaneous;Therapeutic;Tissues;Translating

PROJECT_TITLE: Molecular responses and physiological implications to systemic stimuli in adipocyte progenitor cells

STUDY_SECTION: BMDM

STUDY_SECTION_NAME: Basic Mechanisms of Diabetes and Metabolism Study Section[BMDM]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biodefense and Related Countermeasures;Brain Disorders;Cerebrovascular;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Hematology;Infectious Diseases;Neurosciences

ORG_CITY: WASHINGTON

ORG_NAME: GEORGETOWN UNIVERSITY

ORG_STATE: DC

PHR: This proposal focuses on the negative effects COVID-19 (COronaVIrus Disease-2019) exerts on the brain. Our research will provide insights into the mechanisms contributing to brain pathophysiology in animal models of COVID-19. These findings could also inform on-going and future clinical trials investigating pharmaceutical and hormonal treatments for patients with COVID-19.

PI_NAMEs: SAAVEDRA, JUAN M;SANDBERG, KATHRYN L (contact)

PROGRAM_OFFICER_NAME: DALEY, WILLIAM PATRICK

PROJECT_TERMS: 2019-nCoV;ACE2;Affect;Age;age related;Ageusia;Aging;Angiotensin II Type 1 Receptor Blockers;Angiotensins;Animal Model;Anosmia;Anxiety;arm;Arm Injuries;Attenuated;Autopsy;Behavior;behavioral impairment;Binding;biological adaptation to stress;biological age;biological sex;Blood - brain barrier anatomy;Blood coagulation;Blood Coagulation Factor;Blood Vessels;blood-brain barrier function;Brain;brain endothelial cell;Brain Injuries;brain parenchyma;Brain Pathology;Cells;Central Nervous System;cerebral capillary;Cerebral hemisphere hemorrhage;cerebral microvasculature;cerebral vein;cerebrovascular;Cerebrovascular Disorders;Clinical Trials;Coagulation Process;Cognition;Cognitive;Complement Activation;Confusion;COVID-19;COVID-19 pandemic;COVID-19 patient;COVID-19 risk;COVID-19 severity;cytokine;Cytoprotection;Disease;Endothelial Cells;endothelial dysfunction;Endothelium;Enzymes;Exhibits;Experimental Models;experimental study;Fibrin;Functional disorder;Future;Gram-Negative Bacteria;Hamsters;Headache;Hemorrhage;Hippocampus;Hormonal;Hormones;immunothrombosis;Impairment;Infiltration;Inflammation;Inflammatory;Injury;insight;Interleukin-1 beta;Interleukin-6;Ischemic Stroke;Knockout Mice;Lesion;Light;Lipopolysaccharides;Lung;male;member;Membrane;Memory;Microglia;Modeling;Mus;neuroinflammation;Neurologic Symptoms;neuron loss;Neurons;neuroprotection;NF-kappa B;overexpression;pandemic disease;Pathology;Pathway interactions;Peripheral;Pharmacologic Substance;Platelet Activation;Play;Production;Proteins;Prothrombin;Receptor, Angiotensin, Type 1;Renin-Angiotensin System;Reporting;Research;Role;SARS-CoV-2 infection;Severe Acute Respiratory Syndrome;sex;Signal Pathway;Signal Transduction;Symptoms;Testing;Therapeutic;Thrombin;Thrombosis;Tissues;TLR2 gene;TLR4 gene;Vasoconstrictor Agents;Venous Thrombosis;Viral;Virus

PROJECT_TITLE: Brain pathophysiology in SARS-CoV-2 disease


ED_INST_TYPE: HOSPITALS

ORG_CITY: HOUSTON

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: PROJECT NARRATIVE The proposal investigates the role of RAS-ERK signaling in regulating the function of RbAp46 and RbAp48 proteins during meiosis I and oocyte maturation respectively. Meiosis I and oocyte meiotic maturation are fundamental and conserved processes across metazoans, the knowledge gained from this research has implications to understanding both infertility and birth defects. The role of RbAp46 and RbAp48 in regulating female germ cell development, their intersection with and regulation by the ERK signaling pathway and a role for RbAp46 independent of gene expression have never been defined before and understanding these form the basis of this proposal.

PI_NAMEs: ARUR, SWATHI  (contact)

PROGRAM_OFFICER_NAME: TAYMANS, SUSAN

PROJECT_TERMS: Alleles;Apoptosis;Biochemical;Biological Assay;Biological Models;Caenorhabditis elegans;Chromosome Pairing;Chromosome Segregation;Chromosomes;Complex;Confocal Microscopy;Congenital Abnormality;Coupled;CRISPR/Cas technology;Defect;Development;developmental disease;Down's Syndrome;Dynein ATPase;Embryo;Embryonic Development;Epigenetic Process;epigenetic silencing;Event;Extracellular Protein;Extracellular Signal Regulated Kinases;Failure;Female;female fertility;Female sterility;Fertility;gain of function;Gene Expression;gene repression;Gene Silencing;Genetic;genetic analysis;genetic information;Genetic Models;Germ Cells;Germ Lines;Goals;Gonadal structure;Histone H3;Histones;Homologous Gene;hormonal signals;Human;Image;In Vitro;Infertility;Intervention;Knowledge;Link;Lobular Neoplasia;loss of function;Maintenance;Mammals;MAPK1 gene;Mass Spectrum Analysis;Measures;Mediating;Meiosis;member;Methylation;mimetics;Modeling;Molecular;Molecular Chaperones;Morphogenesis;mutant;Nuclear;Nuclear Envelope;Nuclear Pore;Nuclear Pore Complex;oocyte maturation;Oocytes;Pachytene Stage;Pathway interactions;Phenotype;Phospho-Specific Antibodies;Phosphorylation;Phosphorylation Inhibition;Polycomb;Pore Proteins;Process;protein function;Proteins;Regulation;Reproduction;reproductive fitness;Research;RNA;RNA Interference;Role;segregation;Signal Pathway;Signal Transduction;Sterility;superresolution microscopy;Synaptonemal Complex;Testing;Time;transcriptome sequencing

PROJECT_TITLE: ERK mediated regulation of RbAp46/48 during female germ cell development


NIH_SPENDING_CATS: Genetics;Human Genome;Neurosciences

ORG_CITY: Chicago

ORG_DEPT: BIOLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY

ORG_STATE: IL

PHR: Project Narrative Reorganization of three-dimensional genome structure plays fundamental roles in coupling sensory experiences with the fine-tuning of brain circuits during learning and memory. Genetic mutations in protein regulators of genome architecture cause disorders of human cognition. This project elucidates the principles of genome organization in the brain to provide insights into neurological disorders.

PI_NAMEs: YANG, YUE  (contact)

PROGRAM_OFFICER_NAME: LEE, CRYSTAL ANNE

PROJECT_TERMS: 3-Dimensional;Acute;Adult;Applications Grants;Architecture;Area;Attenuated;Behavior;Biological Process;Brain;Cell Nucleus;Cell Physiology;Chromosomes;Cognition;Cognition Disorders;Control Animal;Coupling;Disease;DNA Sequence;DNA Sequence Alteration;Down-Regulation;Enhancers;Ensure;experience;experimental study;Gene Expression;gene interaction;gene repression;Genes;Genetic;Genetic Transcription;Genome;Genomics;Goals;Human;in vivo;insight;Learning;Link;link protein;long term memory;Maps;Memory;Modeling;Molecular;Motor;motor learning;Mus;Mutation;Nervous System Disorder;neural circuit;NeuroD protein;Neurons;neuroregulation;novel;Nuclear;pharmacologic;Physical condensation;Play;programs;promoter;Proteins;Regulation;Repression;Research;response;Role;Sensory;Structure;Synapses;Testing;transcription factor;Up-Regulation

PROJECT_TITLE: Mechanisms of Genome Architecture Regulation in Motor Learning

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


ORG_CITY: SAN ANTONIO

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

PHR: Project Narrative  Hispanics represent half of the growth in the US population, consider a college education to be extremely important, but have significantly lower graduation rates than other groups. The goal of this postdoctoral training grant is to close this achievement gap in education. Researchers and teachers will be trained who are sensitive to the needs of the Hispanic students and who will serve as role models for undergraduates in higher education.

PI_NAMEs: LECHLEITER, JAMES D;OYAJOBI, BABATUNDE OLUKAYODE (contact)

PROGRAM_OFFICER_NAME: BLATCH, SYDELLA ANNE

PROJECT_TERMS: Achievement;aspirate;Biomedical Research;career;Cities;Collaborations;college;Communities;Country;Education;Educational Curriculum;Educational process of instructing;Enrollment;Environment;evidence base;experience;Faculty;faculty research;Female;Fostering;Goals;Growth;Health;Hispanic;Hispanic Populations;Hispanic-serving Institution;innovation;Institution;interest;Knowledge;Mentors;Population;Positioning Attribute;post-doctoral training;Postdoctoral Fellow;programs;Qualifying;recruit;Research;Research Infrastructure;Research Training;Science;skills;South Texas;Students;teacher;Teacher Professional Development;Teaching Method;Time;Training;Training Programs;undergraduate research;undergraduate research experience;undergraduate student;Underrepresented Populations;United States;Universities

PROJECT_TITLE: San Antonio Biomedical Education and Research

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - D[TWD-D]


ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: NARRATIVE Adipose tissue has a complex relationship with its intrinsic lymphatic vasculature-- it is known that defective lymphatic function promotes obesity and, conversely, obesity compromises lymphatic flow; the mechanisms for these effects are unknown. We have identified a small peptide hormone, neurotensin (NTS), that is produced by lymphatic endothelial cells and which acts on adipocytes to repress thermogenesis. Here we propose to determine how NTS production is regulated, how it affects adipocyte biology, and what impact it has on metabolic health.

PI_NAMEs: ROSEN, EVAN D (contact)

PROGRAM_OFFICER_NAME: BLONDEL, OLIVIER

PROJECT_TERMS: adipocyte biology;Adipocytes;Adipose tissue;Affect;Back;Biology;Blood;blood glucose regulation;Blood Vessels;Brain;Brown Fat;cell type;Cells;Circulation;cold temperature;Complex;Data;Defect;effective therapy;energy balance;Energy Metabolism;Enzymes;Fatty acid glycerol esters;Genes;Genetic Models;Glucose;Goals;Health;Homeostasis;Hormones;Human;Immune;improved;in vitro Model;in vivo;Inflammation;insight;Intercellular Fluid;knock-down;Knock-out;Lipids;lymph flow;Lymphatic;lymphatic development;lymphatic dysfunction;Lymphatic Endothelial Cells;Lymphatic function;Lymphatic System;lymphatic vasculature;lymphatic vessel;Mediating;Metabolic;Metabolic Diseases;Metabolic dysfunction;Metabolism;Molecular;Mus;Neuropeptides;Neurotensin;Neurotensin Receptors;Norepinephrine;novel;Nutrient;Obesity;obesity treatment;paracrine;Pathway interactions;peptide hormone;Peptides;Peripheral;Phenotype;Physiological;Physiology;Process;Production;receptor;Regulation;Repression;Rodent;Role;Series;Signal Transduction;single-cell RNA sequencing;small molecule inhibitor;solute;Structure;Sympathetic Nervous System;Techniques;Temperature;Testing;Text;Thermogenesis

PROJECT_TITLE: Regulation of Adipose-Lymphatic Cross-talk

STUDY_SECTION: POMD

STUDY_SECTION_NAME: Pathophysiology of Obesity and Metabolic Disease Study Section[POMD]


PHR: Suicide prevention is the top clinical priority for VA/DoD and despite VA/DoD recommendations to include family members in suicide related care, there is currently no couples-based suicide-specific intervention. Suicide theories and rehabilitation psychology highlight the importance of healthy interpersonal connection, and research has found that suicidality and relationship functioning are intimately tied. Including a relationship partner in suicide related care has the potential to enhance treatment outcomes and save Veteran lives. This CDA-2 proposal will refine and pilot the first couples-based suicide-specific intervention–Treatment for Relationships and Safety Together (TR&ST) –and examine acceptability, feasibility and preliminary efficacy for a larger Randomized Controlled Trial. This Career Development Award is the first step toward developing a vital program of research within VHA focused on enhancing interpersonal functioning and suicide related care by involving family members in treatment.

PI_NAMEs: KHALIFIAN, CHANDRA  (contact)

PROJECT_TERMS: acceptability and feasibility;Address;Aftercare;Area;Behavior;Behavioral;Caring;Cause of Death;Classification;Clinical;Clinical Practice Guideline;Clinical Treatment;Clinical Trials;Cognitive;Cognitive Therapy;Communication;Conflict (Psychology);Couples;Couples Therapy;Data;Data Analyses;Data Analytics;Development;Disabilities experience;disability;efficacy trial;Environment;Evaluation;Evidence based intervention;Expectancy;Family;Family member;Feeling suicidal;Focus Groups;follow-up;Foundations;Future;Goals;Health;Home;improved;innovation;Interest Group;International;Intervention;Intervention Studies;Interview;K-Series Research Career Programs;Life;Link;Mediating;Mental Depression;Mental Health;Mentors;Methodology;military veteran;novel;Outpatients;Partner in relationship;Patients;Persons;Phase;Post-Traumatic Stress Disorders;prevent;Prevention;primary outcome;programs;Psychology;Randomized, Controlled Trials;Recommendation;recruit;reducing suicide;Rehabilitation therapy;Reporting;Research;Research Personnel;retention rate;Risk;Risk Assessment;Risk Factors;Role;Safety;satisfaction;secondary outcome;Severities;skills;social communication;social engagement;Social Functioning;Stress;suicidal;suicidal behavior;suicidal risk;Suicide;Suicide prevention;suicide rate;telehealth;Telemental;theories;Training;treatment comparison;treatment effect;Treatment outcome;United States;Veterans;Woman;Work

PROJECT_TITLE: Development of a Novel Couples-Based Suicide Intervention: Treatment for Relationships and Safety Together (TR&ST)


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

PHR: Project Narrative The cerebellum receives sensory information, makes short-term predictions, and coordinates movements; its dysfunction can contribute to ataxia, dystonia, dyslexia, and autism spectrum disorders. The sensory input from the environment is received by Purkinje neurons in the cerebellum, which process and transmit it to neurons in the cerebellar nuclei, which further integrate the information with additional sensory signals and then send it to brain regions that control the timing and sequencing of behaviors. In the current application, we propose to study how neural signals are transformed as they are transmitted from Purkinje neurons to neurons in the cerebellar nuclei, and what aspects of signaling change under pathological conditions.

PI_NAMEs: RAMAN, INDIRA M (contact)

PROGRAM_OFFICER_NAME: CHEN, DAOFEN

PROJECT_TERMS: Association Learning;Ataxia;autism spectrum disorder;Behavior;Behavioral;biophysical analysis;Biophysics;Brain region;Cell Nucleus;Cerebellar Nuclei;Cerebellum;Code;comparative;Dyslexia;Dystonia;Environment;Functional disorder;habituation;In Vitro;in vivo;Learning;Link;Monitor;mossy fiber;Motor;motor behavior;motor learning;Motor Neurons;Movement;Mus;Neurons;neurotransmission;Output;Pathologic;Pattern;Physiological;Physiology;Process;Purkinje Cells;response;Sensory;sensory input;Signal Transduction;Synapses;Time;transmission process;Work;Zebrafish

PROJECT_TITLE: Synaptic Coding in the Cerebellar Corticonuclear Circuit


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Brain Disorders;Chronic Pain;Drug Abuse (NIDA only);Neurosciences;Opioid Misuse and Addiction;Opioids;Pain Research;Prescription Drug Misuse;Substance Misuse

ORG_CITY: JACKSON

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF MISSISSIPPI MED CTR

ORG_STATE: MS

PHR: Project Narrative The current opioid crisis has been driven in part by abuse of prescription opioid painkillers. The current proposal will investigate the ability of a novel series of compounds called kappa opioid agonists with unique signaling and behavioral profiles to decrease the abuse-related effects of oxycodone without introducing new side effects. The results of this drug-discovery phase proposal will provide foundational work that could lead to dual-acting compounds and/or drug-combination formulations for the treatment of pain without the burden of abuse liability.

PI_NAMEs: FREEMAN, KEVIN B. (contact)

PROGRAM_OFFICER_NAME: WHITE, DAVID A

PROJECT_TERMS: Absence of pain sensation;abuse liability;Acute Pain;Address;Adopted;Adverse effects;Agonist;Analgesics;Animal Model;antinociception;Azoles;Behavior;Behavioral;behavioral outcome;Characteristics;Clinical;Constipation;Data;Depressed mood;Development;Diuresis;Dose;Drug Combinations;drug discovery;effective therapy;Epidemic;Exhibits;Food;Formulation;Future;Goals;GTP-Binding Proteins;inflammatory pain;kappa opioid receptors;Laboratories;Macaca mulatta;Measures;Mediating;Modality;mu opioid receptors;Nausea;novel;Opioid;Opioid agonist;Opioid Analgesics;opioid epidemic;Outcome;Outcome Measure;Overdose;Oxycodone;oxycodone self-administration;Pain;Pain management;pain model;pain outcome;painful neuropathy;Pathway interactions;Pharmaceutical Preparations;pharmacologic;Pharmacology;Phase;prescription opioid;prescription opioid abuse;Procedures;programs;Public Health;Rattus;Reinforcement Schedule;Reporting;respiratory;Risk;Sedation procedure;sedative;Self Administration;Series;side effect;Signal Transduction;Signaling Protein;Specialist;Techniques;Testing;Therapeutic;therapeutic development;Treatment Efficacy;Visceral pain;Whole Body Plethysmography;Work

PROJECT_TITLE: Deterrents for prescription opioid abuse

STUDY_SECTION: BRLE

STUDY_SECTION_NAME: Biobehavioral Regulation, Learning and Ethology Study Section[BRLE]


PHR: More than 258,000 Veterans with serious mental illness receive VA services. Over 60% of these Veterans have a service-connected disability that impairs their ability to work, go to school, and/or have successful personal lives. Increasing positive outcomes for these Veterans is essential, and requires improving their ability to work with VA providers to achieve their individually identified treatment goals. Veterans with serious mental illness often struggle to communicate effectively, impairing their ability to have their voices heard during treatment appointments. This project will adapt and evaluate a group-based decision-making intervention that targets skill sets that Veterans need to communicate more effectively with providers. Findings from this study will offer useful information about Veteran-provider communication in general, and the decision-making intervention in particular. If the decision-making intervention is effective, it would help Veterans with serious mental illness, and might also help Veterans with other chronic health conditions, like PTSD and chronic pain.

PI_NAMEs: TREICHLER, EMILY  (contact)

PROJECT_TERMS: Accounting;active control;Acute;Address;Administrator;Adult;Appointment;arm;Attitude;Award;Behavior;behavioral health;Budgets;Caring;Chronic;chronic pain;cognitive skill;Collaborations;Communication;Data;Decision Making;Dedications;design;Development;disability;Disease remission;Educational process of instructing;Effectiveness;empowerment;evidence base;experience;Family;Feedback;follow-up;Frequencies;functional improvement;functional outcomes;Future;Goals;Health;Health Services Accessibility;Hearing;Hour;Impairment;implementation science;improved;improved outcome;Individual;Intervention;Manuals;Mental Health;Mentors;Methods;Modification;Motivation;open label;Outcome;Outcome Assessment;Outcome Measure;Outpatients;Participant;Patient Preferences;Patients;Personal Satisfaction;Persons;Phase;Pilot Projects;Play;post intervention;Post-Traumatic Stress Disorders;preference;primary outcome;Process;Provider;provider communication;psychosocial rehabilitation;Quality of life;Randomized;randomized trial;randomized, clinical trials;Recommendation;Recovery;reduce symptoms;rehabilitation service;Rehabilitation therapy;Research;Research Design;Research Personnel;Role;satisfaction;Schools;secondary outcome;Self Efficacy;service delivery;Service delivery model;Services;severe mental illness;Severities;skills;skills training;Social Functioning;social skills;stakeholder perspectives;success;Symptoms;treatment as usual;Treatment outcome;trial comparing;United States Department of Veterans Affairs;Veterans;Voice;Work

PROJECT_TITLE: Improving Collaborative Decision Making in Veterans with Serious Mental Illness


ORG_CITY: PORTLAND

ORG_NAME: PORTLAND VA MEDICAL CENTER

ORG_STATE: OR

PHR: The purpose of the next phase of this epidemiologic project known as “Noise Outcomes In Service members Epidemiology Study 3.0” (NOISE Study 3.0) is to gather information from Veterans recently separated from military service, and active duty Service members, about their military and non-military noise exposures, other relevant military and non-military exposures (e.g., ototoxicants, bombs/blasts, TBIs), tinnitus, hearing loss, and other hearing-related health concerns. Over 1,000 participants have completed baseline testing, and participants complete annual follow-up assessments. The proposed study will continue this longitudinal study and expands the test battery to add behavioral and electrophysiologic measures to test the integrity of multiple stages of auditory processing. The goals of NOISE Study 3.0 are relevant to the VA as they pertain entirely to Veterans' current and future health care needs. This research will offer unparalleled insight into the hearing health of Veterans, informing prevention, intervention, and rehabilitation efforts at the VA.

PI_NAMEs: REAVIS, KELLY M. (contact)

PROJECT_TERMS: Academy;Acoustic Nerve;active duty;Address;Adverse effects;Affect;Animals;Audiology;Auditory;auditory processing;Award;Behavioral;blast exposure;cell injury;Central Auditory Diseases;Central Auditory Processing Disorder;Chemical Exposure;Chemicals;Chronic;Clinical;Clinical Research;Cochlea;cochlear synaptopathy;Communication;comorbidity;Congresses;cost;Data;Data Collection;Data Set;Department of Defense;design;disability;Distress;early onset;Electrophysiology (science);Enrollment;Environmental Exposure;epidemiologic data;Epidemiology;epidemiology study;Etiology;Evaluation;Event;Explosion;Exposure to;follow up assessment;follow-up;Functional disorder;Funding;Future;Goals;Grant;Hair Cells;Health;Health Services;Healthcare;Hearing;hearing impairment;hearing loss risk;Hearing problem;High-Frequency Hearing Loss;Human;improved;Individual;information gathering;Injury;Inner Hair Cells;insight;Institute of Medicine (U.S.);interest;Intervention;Lead;Life Cycle Stages;Longitudinal Studies;Measures;Medical;Medical Research;Medicine;Mental Health;Methods;Military Personnel;military service;Modeling;Nerve Fibers;Nervous System;Noise;noise exposure;Occupational Exposure;Occupations;ototoxicity;Outcome;Participant;participant enrollment;Pathway interactions;Pattern;Peripheral;Persons;Phase;physical conditioning;Physiological;Population;post 9/11;prevent hearing loss;Prevention;Prevention strategy;programs;Psyche structure;Quality of life;Recommendation;Recreation;Rehabilitation Centers;rehabilitation research;Rehabilitation therapy;Reporting;Request for Proposals;Research;research and development;Research Personnel;Research Support;response;Risk;Risk Factors;risk prediction;Role;Seminal;Series;service member;Services;Site;Societies;Solvents;Source;Surveys;Synapses;Target Populations;Testing;Time;Tinnitus;Traumatic Brain Injury;treatment strategy;United States Department of Veterans Affairs;Validation;Veterans;Work

PROJECT_TITLE: Effects of Noise and Other Exposures on Auditory Functioning in Post-9/11 Veterans: NOISE Study 3.0


NIH_SPENDING_CATS: Aging;Biotechnology;Brain Disorders;Genetics;Neurodegenerative;Neurosciences;Parkinson's Disease;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: CHICAGO

ORG_DEPT: NEUROLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: Project Narrative The purpose of the proposed research is to develop a platform to mechanistically examine genetic modifiers of PD in patient-derived neurons, microglia and astrocytes. We hypothesize that these glial cells normally offer protection to neurons, and we proposed to examine how this protection becomes harmful in PD. We will focus on GBA1-PD but the main idea was to develop these novel experimental approaches as a platform for other studies in PD, as well neurodegeneration more broadly.

PI_NAMEs: KRAINC, DIMITRI  (contact)

PROGRAM_OFFICER_NAME: SARRAF, SHIREEN AKHAVAN

PROJECT_TERMS: Astrocytes;Award;Biology;Cells;Coculture Techniques;Disease;dopaminergic neuron;follow-up;Freedom;Functional disorder;gene discovery;Genes;Genetic;genetic analysis;genetic variant;Human;induced pluripotent stem cell;innovative technologies;Link;Lysosomes;Microglia;Midbrain structure;Mitochondria;Mus;Nerve Degeneration;Neuroglia;Neurons;novel;Parkinson Disease;Pathway interactions;Patients;Phenotype;programs;Research;Time

PROJECT_TITLE: Mechanistic Analysis of Genetic Modifiers in Parkinson's Disease


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Infectious Diseases;Malaria;Prevention;Rare Diseases;Vector-Borne Diseases

ORG_CITY: SEATTLE

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative: Malaria burden reduction and malaria elimination require an evidence-based approach to quantifying the ecology of mosquitoes, human-mosquito interactions, and residual transmission. The idiosyncratic challenges facing vector control are best addressed through adaptive vector control, which combines elements of integrated vector control and adaptive management. We propose to develop adaptive vector control, in partnership with the Bioko Island Malaria Elimination Program, to quantify residual transmission and spatially target vector control in the urban context of Malabo, Bioko Island, Equatorial Guinea.

PI_NAMEs: SMITH, DAVID L. (contact)

PROGRAM_OFFICER_NAME: COSTERO-SAINT DENIS, ADRIANA

PROJECT_TERMS: Address;Adult;Africa South of the Sahara;African;Area;Automobile Driving;Beds;Behavior;Bite;Capital;Cities;Culicidae;Data;Decision Making;design;Development;Ecology;Elements;Equatorial Guinea;Evaluation;evidence base;Goals;Habitats;Heterogeneity;Human;improved;Incidence;innovation;Insecticides;Intervention;Investments;Island;Malaria;malaria transmission;Maps;Methodology;Methods;Modeling;Monitor;novel;Outcome;Outcome Measure;Play;Policies;Population;Population Dynamics;Populations at Risk;Process;Productivity;programs;Randomized, Controlled Trials;Research Design;Residual state;Role;Sampling;Scheme;simulation;sound;Source;Structure;success;Testing;transmission process;Travel;Uncertainty;urban setting;vector;vector control;vector transmission

PROJECT_TITLE: Spatial Targeting and Adaptive Vector Control for Residual Transmission and Malaria Elimination in Urban African Settings

STUDY_SECTION: VB

STUDY_SECTION_NAME: Vector Biology Study Section[VB]


NIH_SPENDING_CATS: Behavioral and Social Science;Breastfeeding, Lactation and Breast Milk;Childhood Obesity;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Diabetes;Maternal Health;Maternal Morbidity and Mortality;Nutrition;Obesity;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Women's Health Research

ORG_CITY: Oakland

ORG_NAME: KAISER FOUNDATION RESEARCH INSTITUTE

PHR: The overall study goal is to determine whether early postnatal factors can counteract the adverse influences of maternal gestational diabetes during fetal life, and ultimately have lasting benefits on future metabolic health of the child. This study will provide new insights on early postnatal factors (breastfeeding, infant diet including sugar-sweetened beverages, sleep, and temperament) specifically for this high-risk group of children exposed to gestational diabetes, and the ability of these factors to reduce their future risk of obesity and type 2 diabetes.

PI_NAMEs: GUNDERSON, ERICA PAULINE (contact)

PROGRAM_OFFICER_NAME: LINDER, BARBARA

PROJECT_TERMS: Accounting;Adolescence;Adverse effects;adverse pregnancy outcome;Affect;Age;Animal Experiments;Anthropometry;Behavior;Birth;Body mass index;Breast Feeding;Child;Child Health;Childhood diabetes;Classification;Clinical Data;cohort;Data;Development;Diabetes Mellitus;Diagnosis;Diet;Discipline of obstetrics;Disease;Electronic Health Record;Epidemiology;Exposure to;falls;feeding;fetal;follow-up;Food;Fruit;Funding;Future;Gestational Age;Gestational Diabetes;gestational weight gain;Glucose;Glucose Intolerance;glucose tolerance;Goals;Growth;Health;Health Status;Height;High birth weight infant;high risk;high risk population;Homeostasis;Human;Hyperglycemia;improved;in utero;Infant;insight;Insulin;Integrated Health Care Systems;Intervention;Juice;Knowledge;Life;Life Style;Link;Lipids;maternal diabetes;maternal obesity;Measures;member;Metabolic;Modification;Mothers;Neonatal;neonatal outcome;newborn adiposity;Non-Insulin-Dependent Diabetes Mellitus;nutrition;Obesity;obesity in children;obesity prevention;obesity risk;offspring;OGTT;Outcome;Outcome Study;Pattern;perinatal outcomes;Persons;postnatal;postnatal period;Prediabetes syndrome;Pregnancy;Pregnant Women;prenatal;prenatal exposure;primary outcome;prospective;Prospective cohort;Prospective Studies;Protocols documentation;Puberty;recruit;Research;Severities;Sleep;sleep behavior;sociodemographics;Standardization;sugar;Surveys;sweetened beverage;Telephone;Temperament;Time;Update;Visit;Weight;Woman;Women's study;Youth

PROJECT_TITLE: Fetal and Early Postnatal Influences on Child Metabolic Health After Gestational Diabetes


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Genetics;Neurosciences;Physical Injury - Accidents and Adverse Effects;Precision Medicine;Prevention;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: PHOENIX

ORG_NAME: ST. JOSEPH'S HOSPITAL AND MEDICAL CENTER

ORG_STATE: AZ

PHR: PROJECT NARRATIVE Brain edema is a devastating process affecting millions of people; yet, there is no cure- it remains a fundamental cause of death and disability in TBI and many other diseases, costing billions of dollars. Given the complex network of pathways contributing to brain edema, compounded by individual variation, it is inevitable that current non-specific therapies are unsuccessful at improving outcomes- harnessing patient differences to direct precision medicine is imperative for effective treatment. This translational work seeks to address this major deficiency: by evaluating effects of individual differences and targeted treatment on edema subtypes in a key pathway of TBI edema (Sur1-Trpm4), it aims to provide clinicians and researchers with a sophisticated toolkit to identify and stratify patients at risk, target the intervention, prognosticate, and optimize clinical trial design, thus directly advancing precision medicine-based care and the NINDS mission to reduce the burden of neurological disease.

PI_NAMEs: JHA, RUCHIRA MENKA (contact)

PROGRAM_OFFICER_NAME: UMOH, NSINI ALEASE

PROJECT_TERMS: Address;Affect;Brain;Brain Edema;Brain Injuries;Brain region;Caring;Cations;causal variant;Cause of Death;cell type;Cells;Cerebral Edema;Cerebral Edema Management;Cerebrum;Clinical;clinical care;clinical translation;Clinical Trials;Clinical Trials Design;clinically relevant;cohort;Collaborations;Complex;controlled cortical impact;Contusions;cost;Data;Dedications;design;Diffuse;disability;Disease;early phase clinical trial;Edema;effective therapy;endophenotype;Evaluation;fluid percussion injury;Foundations;Future;Generations;Genes;Genetic;Genetic Predisposition to Disease;Genetic Risk;Genetic Variation;Glyburide;Goals;Growth;Guidelines;Heterogeneity;high risk;Human;Hypotension;Ideal 1;Image;improved;improved outcome;in vivo evaluation;Individual;Individual Differences;individual variation;Injury;innovation;International;Intervention;Intracranial Pressure;Knock-in Mouse;Knock-out;Knowledge;Link;Magnetic Resonance Imaging;Maps;Measurable;Measures;Methodology;Mission;Modeling;Molecular;molecular targeted therapies;mouse model;Mus;National Institute of Neurological Disorders and Stroke;Nervous System Disorder;novel;operation;Outcome;Pathway Analysis;Pathway interactions;Patient risk;Patient Selection;patient stratification;Patients;Persons;Pharmaceutical Preparations;Phase;phase II trial;Phenotype;Physiological;potential biomarker;pre-clinical;precision medicine;preclinical study;prevent;Preventive;Probability;Process;Prognosis;prognostication;Property;protein expression;Proteins;Protocols documentation;radiological imaging;receptor;Research;Research Personnel;Resources;response;Risk;risk stratification;Single Nucleotide Polymorphism;SNP genotyping;Sodium;sulfonylurea receptor;targeted treatment;Testing;therapeutic target;Time;tool;Transgenic Mice;Transgenic Organisms;Translating;Traumatic Brain Injury;treatment optimization;treatment response;trial design;Validation;Variant;Water;Work

PROJECT_TITLE: A Translational Evaluation of Sur1-Trpm4 Imaging Endophenotypes and Genetics to Direct Precision Medicine for Cerebral Edema After Traumatic Brain Injury

STUDY_SECTION: BINP

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Brain Disorders;Cardiovascular;Clinical Research;Heart Disease;Neurosciences

ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

PHR: PROJECT NARRATIVE We have developed a new method to non-invasively measure skin sympathetic nerve activity. This research program proposes to determine if the skin sympathetic nerve activity can be used as a prognostic biomarker for neurological status during targeted temperature management for cardiac arrest and to risk stratify patients for recurrence of atrial fibrillation after ablation therapy. Because heart diseases and cardiac arrhythmias are associated with significant mortality and morbidity, this research project has significant public health implications.

PI_NAMEs: EVERETT, THOMAS H (contact)

PROGRAM_OFFICER_NAME: TJURMINA, OLGA A

PROJECT_TERMS: Ablation;Anoxic Encephalopathy;Applications Grants;Arrhythmia;Atrial Fibrillation;autonomic nerve;Biological Markers;canine model;Canis familiaris;Cardiac;Cardiac ablation;Cardiology;Cardiopulmonary Resuscitation;Cardiovascular Diseases;Cardiovascular system;Cerebral Ischemia;Circulation;clinical investigation;Consent;Data;design;Disease;Electrocardiogram;Electrodes;Event;follow-up;Future;Guidelines;Heart Arrest;Heart Atrium;Heart Diseases;Heart failure;Heart Rate;heart rate variability;Hospitalization;Hour;Human;Hybrids;improved;insight;Intervention;Left;Measures;Methods;Morbidity - disease rate;mortality;natural hypothermia;Nerve;Neurological outcome;neurological recovery;Neurological status;neuromechanism;neuroprotection;neuroregulation;out-of-hospital cardiac arrest;Outcome;patient stratification;Patients;Percutaneous Catheter Ablation;Physiological;Procedures;Prognostic Marker;programs;Progressive Disease;prospective;Protocols documentation;Public Health;Pulmonary veins;Recurrence;Research;Research Project Grants;risk stratification;Sinoatrial Node;Skin;Source;Structure of stellate ganglion;subcutaneous;Subcutaneous Tissue;success;Surface;Surrogate Endpoint;Survival Rate;Temperature;Testing;Therapeutic;Translating;Ventricular Arrhythmia;Visit;Visualization

PROJECT_TITLE: SKNA as a biomarker for cardiovascular events

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-TDPS-R(01)]


ADMINISTERING_IC: AG

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PUBLIC HEALTH RELEVANCE: The goal of this program is to train graduate students, physician scientists and postdoctoral fellows and prepare them for research careers in age-related neurodegenerative diseases with an emphasis on Alzheimer’s disease and the Alzheimer’s disease related dementias (ADRD), which include Parkinson’s Disease (PD) and frontotemporal lobar degeneration (FTLD). These diseases are a significant and expanding public health problem due to the rapidly aging global population.

PI_NAMEs: CHEN-PLOTKIN, ALICE S (contact);LEE, EDWARD BYUNG-HA;LEE, VIRGINIA M

PROGRAM_OFFICER_NAME: HAAKENSON, CHELSEA MARIE

PROJECT_TERMS: age related neurodegeneration;Training

PROJECT_TITLE: Training in age related neurodegenerative diseases


NIH_SPENDING_CATS: Brain Disorders;Neurosciences

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE It is well established that the hippocampus, entorhinal cortex, and prefrontal cortex as well as the coordination of activity across these brain regions is disrupted in any of the major neurological, neurodegenerative, and psychiatric diseases. Despite the knowledge that these circuits are particularly vulnerable in brain diseases, the diversity of memory computations that these brain regions support is only beginning to be revealed. By identifying how neural computations are performed and coordinated across brain regions, our results will be the foundation for therapies that profoundly improve cognitive function.

PI_NAMEs: LEUTGEB, STEFAN  (contact)

PROGRAM_OFFICER_NAME: BABCOCK, DEBRA J

PROJECT_TERMS: Animals;Area;Award;Behavior;Brain;Brain Diseases;Brain region;cell cortex;Cells;Code;cognitive function;Data;Deterioration;Disease;Dorsal;entorhinal cortex;Event;follow-up;Foundations;Future;Hippocampus;improved;Interruption;Knowledge;Medial;Memory;Memory impairment;memory retention;Mental disorders;Nervous System Disorder;neural;Neurodegenerative Disorders;Neurons;Pathology;Pattern;Population;Prefrontal Cortex;Role;Running;Short-Term Memory;Time;Variant;way finding;Work

PROJECT_TITLE: Memory computations across hippocampal, entorhinal, and prefrontal circuits


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Aging;Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurodegenerative;Neurosciences;Pediatric

ORG_CITY: GAINESVILLE

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE Adults with autism spectrum disorder (ASD) are highly susceptible to neurodegenerative diseases. The goal of this study is to uniquely identify functional and structural changes in cerebellum and basal ganglia and their contributions to neuromotor impairments in adults with ASD. The proposed studies will provide fundamental insights into the aging process in ASD to inform diagnosis, management, and monitoring strategies.

PI_NAMEs: WANG, ZHENG  (contact)

PROJECT_TERMS: Acceleration;adolescent with autism spectrum disorder;Adult;adult with autism spectrum disorder;Age;aged;Aging;aging process;aging related;aging related disease;Anatomy;Anisotropy;Area;autism spectrum disorder;autistic children;Axon;balance testing;Basal Ganglia;Behavioral;biobehavior;Biomechanics;Biometry;Brain;Cell Nucleus;Cerebellar degeneration;Cerebellar Diseases;Cerebellum;Child;Clinical;Clinical assessments;comorbidity;comparison control;Data;design;Deterioration;Diagnosis;Diffusion Magnetic Resonance Imaging;Early Diagnosis;Equilibrium;experience;extracellular;Fingers;Functional Imaging;Functional Magnetic Resonance Imaging;General Population;Globus Pallidus;Goals;grasp;gray matter;high reward;Hip region structure;human old age (65+);imaging approach;imaging study;Impairment;Infant;innovation;insight;Intervention;Knowledge;Lateral;Lobule;Magnetic Resonance Imaging;Measures;Mission;Monitor;Motor;motor deficit;Movement;Movement Disorders;Musculoskeletal Equilibrium;Nerve Degeneration;Neurodegenerative Disorders;Neurodevelopmental Disorder;neurophysiology;Parietal Lobe;Parkinsonian Disorders;Patients;Performance;Physics;Postural adjustments;Posture;Predisposition;Prevalence;Production;putamen;Qualifying;Quality of life;quantification of aging;Reporting;Research;Research Personnel;Severities;sex;structural imaging;Substantia nigra structure;Testing;Time;Tissues;trait;Transportation;Water;water diffusion;white matter;Work

PROJECT_TITLE: Cerebellar and Basal Ganglia Markers Underlie Neuromotor Impairments in Adults with Autism Spectrum Disorder (ASD)

STUDY_SECTION: MFSR

STUDY_SECTION_NAME: Motor Function, Speech and Rehabilitation Study Section[MFSR]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

ORG_CITY: ROCHESTER

ORG_NAME: UNIVERSITY OF ROCHESTER

ORG_STATE: NY

PHR: Project Narrative The Genomic Intensive Data Science Research, Education and Mentorship (GIDS-REM) program at the University of Rochester creates a fellowship to train, mentor, and develop research experience in Genomics in data science master’s students from underrepresented groups. This program will increase the number of researchers with strong quantitative skills in the genomics workforce, diversify and strengthen the larger genomics community.

PI_NAMEs: FAY, JUSTIN C;LARRACUENTE, AMANDA MARIE (contact);MCCALL, MATTHEW NICHOLSON

PROGRAM_OFFICER_NAME: XIRASAGAR, SANDHYA

PROJECT_TERMS: Admission activity;Advertising;Benchmarking;Biomedical Research;cancer genomics;career;Charge;Clinical Sciences;cohort;Communities;community building;Competence;Coupled;Data Analyses;Data Science;Data Scientist;design;Doctor of Philosophy;Education;Educational Curriculum;Educational workshop;Employment;Enrollment;Ensure;equity, diversity, and inclusion;experience;Explosion;Faculty;faculty mentor;Fellowship;Foundations;Future;gender diversity;genome resource;genome sciences;genomic data;Genomics;Historically Black Colleges and Universities;improved;Industry;innovation;instrument;interest;Internships;Leadership;Malignant Neoplasms;Master of Science;matriculation;Medical center;meetings;member;Mentors;Mentorship;Methodology;Modernization;Positioning Attribute;Productivity;Program Effectiveness;Program Evaluation;programs;Qualifying;racial diversity;recruit;Research;Research Personnel;Research Training;Resources;Scholarship;Schools;Self Efficacy;skills;student training;Students;summer research;Training;translational genomics;Translational Research;Underrepresented Minority;underrepresented minority student;Underrepresented Populations;Underrepresented Students;Universities;Work


NIH_SPENDING_CATS: Aging;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Cerebrovascular;Neurosciences;Stroke

ORG_CITY: DURHAM

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: NORTH CAROLINA CENTRAL UNIVERSITY

ORG_STATE: NC

PHR: Project Narrative  There is an acute need to develop neuroprotective drugs to prevent or/and protect neuronal cell damage and death caused by ischemia/reperfusion, hypoxia or cytotoxic agents in the brain. Plant- based expression system can be used to produce asialo-rhuEPO, a non-hematopoietic recombinant human EPO derivative lacking sialic acid, which could be used as a neuroprotective agent for preventing and protecting brain damage from ischemia/reperfusion injury.

PI_NAMEs: XIE, JIAHUA  (contact)

PROGRAM_OFFICER_NAME: BERNAL, FEDERICO

PROJECT_TERMS: 3-Dimensional;Acute;Adverse effects;aged;aging population;angiogenesis;Animal Model;Biomedical Research;Blood flow;Brain;Brain Injuries;cardioprotection;Cause of Death;Cell Death;cell injury;clinical practice;conditioning;Cytotoxic agent;disability;drug candidate;Excision;Exhibits;Foundations;Future;Galactosyltransferases;Genes;glycosylation;Grant;Hematopoietic;Human;Hypoxia;Impairment;In Vitro;in vivo;Inflammation;Injury;innovation;Intervention;Ischemia;Ischemic Brain Injury;Ischemic Stroke;Mammalian Cell;Mediating;Middle Cerebral Artery Occlusion;molecular marker;mouse model;Mus;Nervous System Physiology;neurogenesis;Neurologic;Neurologic Effect;Neurological outcome;Neurons;neuroprotection;Neuroprotective Agents;new therapeutic target;Obstruction;old mice;Pathway interactions;Pharmaceutical Preparations;pharmacologic;Plants;Polysaccharides;prevent;Procedures;Process;Property;protective effect;recombinant human erythropoietin;Recombinants;Reperfusion Injury;Reperfusion Therapy;Reporting;Research Activity;Role;Sialic Acids;sialylation;side effect;Signal Pathway;Solid;Stroke;stroke clinical trials;Structure;Students;success;Survival Rate;System;Testing;Time;tissue repair;training opportunity;Transgenic Plants;Translating;Underrepresented Minority

PROJECT_TITLE: In Vivo Neuroprotective Properties and Action Mechanism(s) of Plant-produced Asialo-erythropoietin


NIH_SPENDING_CATS: Nutrition;Obesity

ORG_CITY: LOS ANGELES

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative We have identified the enzyme Lpcat3 as a potential link between the intake of lipids from the diet and the development of obesity and diabetes. We will determine how the incorporation of different lipids into adipocyte membranes affects the ability of fat cells to store and metabolize lipids and the balance between these processes. Modulation of Lpcat3 activity could represent a new opportunity to intervene in the development of obesity and diabetes.

PI_NAMEs: TONTONOZ, PETER J (contact)

PROGRAM_OFFICER_NAME: GUPTA, DHANANJAY

PROJECT_TERMS: Acids;Address;adipocyte differentiation;Adipocytes;Adipose tissue;Affect;Animals;Arachidonic Acids;Automobile Driving;Bioenergetics;biological adaptation to stress;Brown Fat;Catabolism;Cell Nucleus;Cells;Cellular Morphology;Collaborations;Data;Defect;detection of nutrient;Diabetes Mellitus;Diet;diet-induced obesity;dietary;dietary excess;Dietary Fats;Dietary Fatty Acid;endoplasmic reticulum stress;energy balance;Energy Metabolism;Environment;Enzymes;Equilibrium;Exposure to;fatty acid oxidation;FGF21 gene;fibroblast growth factor 21;Gene Expression;genetic manipulation;Goals;Hepatic;High Fat Diet;Homeostasis;Intake;interest;Knockout Mice;Laboratories;Link;Linoleic Acids;Lipids;loss of function;Mediator;Membrane;Membrane Lipids;Metabolic;Metabolic Diseases;Mitochondria;mitochondrial membrane;Modeling;Morphology;mouse model;Mus;novel;Nutrient;Obesity;obesity development;obesogenic;Organelles;oxidation;patch clamp;Pathologic;Pathway interactions;Phenotype;Phospholipids;Physiological;Physiology;Polyunsaturated Fatty Acids;Population;Predisposition;Process;Production;Publishing;Regulation;Regulatory Pathway;Resistance;Respiration;response;Role;Signal Transduction;Stress;Testing;thermal stress;Time;Tissue Expansion;Tissue membrane;Tissues;Up-Regulation

PROJECT_TITLE: Membrane homeostasis in adipose physiology and obesity


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Pediatric;Social Determinants of Health

ORG_CITY: NEW ORLEANS

ORG_NAME: XAVIER UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: PROJECT NARRATIVE Xavier University of Louisiana through the XULA-MOLE project, aims to increase interest of high school students in pursuing careers in the STEM fields or in biomedical sciences in order to impact public health literacy and increase workforce diversity. This will be accomplished using inquiry-based laboratory instruction and improved research support and training for educators. The proposed research is particularly relevant to the mission of the NIH as it aims to enhance health and reduce the burden of illness by providing scientific training and mentorship to high schools that have large populations of underrepresented minority and underprivileged students.

PI_NAMEs: ALI, MEHNAAZ FATIMA (contact)

PROGRAM_OFFICER_NAME: FAUPEL-BADGER, JESSICA

PROJECT_TERMS: Active Learning;Address;Area;Biological Models;Biomedical Research;Breathing;burden of illness;career;classroom research;Collaborations;college;design;Development;Disparity;Education;Educational Curriculum;Educational process of instructing;Educational workshop;Engineering;expectation;experimental study;Exposure to;Faculty;Faculty Workshop;field trip;Fostering;Funding;Goals;Health;health disparity;health literacy;high school;High School Faculty;high school program;High School Student;Hurricane;improved;Individual;Infrastructure;Instruction;interest;Laboratories;laboratory experience;laboratory experiment;laboratory module;Lead;Learning;Louisiana;Mentors;Mentorship;Mission;Modeling;novel;outreach;Participant;peer;peer coaching;posters;Process;programs;Public Health;Research;research and development;Research Design;Research Project Grants;Research Support;Research Training;Resource-limited setting;Resources;Schools;Science;science education;science teacher;Science, Technology, Engineering and Mathematics;STEM field;STEM student;Students;summer research;symposium;synergism;teacher;Teacher Professional Development;Training;undergraduate student;Underrepresented Minority;Underrepresented Populations;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Xavier University of Louisiana-Mobile Outreach for Laboratory Enrichment (XULA-MOLE)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(56)R]


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Cancer;Clinical Research;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Rare Diseases

ORG_CITY: KAMPALA

ORG_COUNTRY: UGANDA

ORG_FIPS: UG

ORG_NAME: INFECTIOUS DISEASES INSTITUTE

PHR: In sub-Saharan Africa, Kaposi’s sarcoma (KS) is one of the most commonly reported cancers in the general population, and it is associated with considerable morbidity and mortality in HIV-infected individuals. Unfortunately, the limited subject matter expertise and lack of resources to enhance research capacity for understanding the nature of the problem means that KS will remain a public health burden for some time. Developing local scientists into independent investigators dedicated to HIV-associated cancer research is therefore an important goal. This K43 project addresses the problem by supporting the career development of an emerging young scientist dedicated to understanding the impact of KS on mortality among the HIV-infected population, to identify potential biologic pathways that predict death after KS diagnosis and to develop a prediction rule for mortality among HIV-infected individuals with KS in the region. This investment will increase the possibility of developing strategies to reduce the burden of KS among HIV-infected individuals in the era of effective anti-retroviral therapy.

PI_NAMEs: BYAKWAGA, HELEN  (contact)

PROGRAM_OFFICER_NAME: BANSAL, GEETHA PARTHASARATHY

PROJECT_TERMS: Address;Adult;Africa;Africa South of the Sahara;AIDS related cancer;Algorithms;anti-cancer research;antiretroviral therapy;Attenuated;Award;Biological;Biological Markers;cancer diagnosis;career;career development;CD4 Positive T Lymphocytes;Cell Count;Cessation of life;Clinical;Clinical Management;Clinical Research;clinically relevant;co-infection;Data;Dedications;Development;Development Plans;Diagnosis;Disease;Disease Progression;effective intervention;Epidemiology;Etiology;experience;Funding;Future;General Population;Goals;high risk;HIV;HIV diagnosis;HIV Infections;HIV-1;Human Herpesvirus 8;Immune;immune function;Immunologic Surveillance;improved;improved outcome;Incidence;Individual;Infection;Integration Host Factors;International;Intervention;Investments;Kaposi Sarcoma;Knowledge acquisition;Laboratories;Learning;Link;Lymphopenia;Malignant - descriptor;Malignant Neoplasms;Measurement;Mediating;Mentors;Mentorship;Metabolic;Morbidity - disease rate;mortality;Mortality Determinants;mortality risk;Nature;Newly Diagnosed;Pathway interactions;Patients;Persons;Plasma;Play;point of care;Population;predictive modeling;Public Health;reconstitution;Reporting;Research;research and development;Research Personnel;Research Proposals;Research Training;Resources;response;Risk;RNA;Role;Scientist;skills;survival prediction;systemic inflammatory response;Testing;therapy development;Time;Viral;Viral Load result;Viremia;Virus Replication;Work

PROJECT_TITLE: Quantifying, Explaining and Predicting Survival After Diagnosis of HIV-related Kaposi Sarcoma in East Africa

STUDY_SECTION_NAME: International and Cooperative Projects - 1 Study Section[ICP1]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Autoimmune Disease;Eye Disease and Disorders of Vision;Immunotherapy

ORG_CITY: CLEVELAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

ORG_STATE: OH

PHR: Project Narrative  This project will use our unique complement-related gene knockout mice to study the previously unknown role of complement in regulating already primed T cells in a model of autoimmune uveitis, and to test our novel complement inhibitors as new therapeutics for this blinding disease.

PI_NAMEs: LIN, FENG C (contact)

PROGRAM_OFFICER_NAME: GORDIYENKO, NATALIYA

PROJECT_TERMS: Active Immunization;Adoptive Transfer;antagonist;Antigen-Presenting Cells;antigen-specific T cells;Apoptosis;Arrestins;autoimmune pathogenesis;autoimmune uveitis;autoreactive T cell;Blindness;Blood-Retinal Barrier;C3AR1 gene;CD55 Antigens;Cell membrane;cell motility;Cell Physiology;Cells;Clinical;clinical development;Complement;Complement 3a;Complement 5a;Complement Activation;Complement Inactivators;Complement Receptor;cytokine;Data;Dendritic cell activation;Dendritic Cells;Development;Disease;Disease remission;effective therapy;effector T cell;efficacy evaluation;efficacy testing;Etiology;experimental study;Eye;Foundations;FOXP3 gene;Future;Generations;Human;improved;In Vitro;in vivo;Infiltration;Inflammation;inhibitor;Innate Immune System;interstitial retinol-binding protein;Knock-out;knockout gene;Knockout Mice;Lipid Bilayers;Lipids;Mediating;migration;Modeling;monolayer;mouse model;Mus;nanoparticle;Nature;new therapeutic target;novel;novel therapeutics;Pathogenesis;Pathogenicity;Pathologic;Patients;Peripheral;Permeability;prevent;Production;Proliferating;Proteins;Publishing;Rattus;Reagent;receptor;Recombinants;recruit;Regulation;Regulatory T-Lymphocyte;Relapse;Retina;Rodent Control;Role;Signal Transduction;Solid;Surface;T cell infiltration;T cell response;T-Cell Activation;T-Lymphocyte;Tail;targeted treatment;Testing;Therapeutic;Tissues;Transgenic Mice;translational study;Work

PROJECT_TITLE: New mechanisms by which complementýregulates the pathogenesis of experimental autoimmune uveitis


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric

ORG_CITY: ANN ARBOR

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative DSDR promotes research in population dynamics and allied fields by providing access to data that can be used to study critical issues in public health, including child and maternal health, aging, and environmental influences on disease and overall well-being. By continuing to engage the demographic community with important data sources and colleagues from multiple related disciplines, DSDR encourages research that both contributes to fundamental knowledge about the nature and behavior of living systems and applies that knowledge to enhance health, lengthen life, and reduce illness and disability.

PI_NAMEs: ALEXANDER, JOSEPH T. (contact);MARCOTTE, JOHN EDWIN

PROGRAM_OFFICER_NAME: CAPPS, RANDOLPH CHRISTOPHER

PROJECT_TERMS: Adolescent;adolescent health;Adult;Aging;Ally;analytical tool;archive data;Area;Behavior;Biological;Biological Markers;Child;Child Health;Code;Communicable Diseases;Communities;community building;Contraceptive Usage;Custom;Data;Data Analyses;data archive;Data Collection;data enclave;data exploration;data library;data repository;data resource;Data Set;data sharing;Data Sources;Demographer;Deposition;Development;disability;Discipline;Disclosure;Disease;disorder prevention;Documentation;Elements;Ensure;Environment;expectation;FAIR principles;Funding;gene environment interaction;Generations;Genetic;Genomics;global health;Goals;Health;Health behavior and outcomes;health disparity;healthy pregnancy;High Performance Computing;human subject protection;improved;Individual;Infrastructure;innovation;interest;International;Knowledge;Learning;Life;Life Cycle Stages;life span;Link;Maternal and Child Health;Maternal Health;Metadata;Michigan;migration;Molecular;National Institute of Child Health and Human Development;Nature;neuroimaging;Organism;outreach;Personal Satisfaction;Policy Maker;Politics;Population;Population Dynamics;Population Sciences;Population Study;Privacy;Production;Public Health;Records;Reproducibility;Research;Research Infrastructure;Research Personnel;Research Priority;Research Project Grants;Research Support;Resources;Respondent;Risk;Role;Sample Size;Scientific Advances and Accomplishments;Scientist;secondary analysis;Secure;social;social media;Source;Specimen;Standardization;Strategic Planning;Surveys;symposium;System;targeted biomarker;Techniques;tool;Training;training opportunity;transition to adulthood;Universities;usability;virtual;webinar

PROJECT_TITLE: Data Sharing and Archiving for Demographic Research


ADMINISTERING_IC: LM

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Bioengineering;Cancer;Colorectal Cancer;Data Science;Digestive Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Precision Medicine;Prevention

ORG_CITY: BOSTON

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

ORG_STATE: MA

PHR: Project Narrative The research proposal addresses the pressing need for advanced statistical tools that meet challenges in current development of prediction models with high dimensional predictors using noisy data from electronic medical records augmented by a small amount of gold standard outcomes. By providing statistical tools that enable clinical investigators to effectively develop accurate and interpretable risk prediction models, this proposal will join prior and ongoing research activities towards the goal of finding efficient and cost effective personalized disease management strategies.

PI_NAMEs: CAI, TIANXI  (contact);GUO, ZIJIAN

PROGRAM_OFFICER_NAME: YOON, SUNG SUG

PROJECT_TERMS: adalimumab;Address;Adoption;Aftercare;Algorithms;antagonist;biobank;Biological;burden of illness;Clinical;clinical application;Clinical Data;Clinical Investigator;clinical practice;Clinical Trials;Code;cohort;Cohort Studies;Collaborations;colon cancer risk;Colon Carcinoma;colorectal cancer risk;Complex;Computer software;Computerized Medical Record;cost;cost effective;Data;data integration;Data Set;deep learning;denoising;Development;Dimensions;Disease;Disease Outcome;Disease Progression;disorder risk;electronic data;electronic health information;Electronic Health Record;electronic health record system;Face;Factor X;Genetic;genomic data;Goals;Healthcare;Healthcare Systems;Heterogeneity;high dimensionality;Human;improved;individualized medicine;Inflammatory;Inflammatory Bowel Diseases;infliximab;Label;large datasets;Learning;learning strategy;machine learning method;machine learning model;Malignant Neoplasms;Massachusetts;Measurement;Medical Records;Methodology;Methods;Modeling;multiple data sources;novel;Oncology;Outcome;outcome prediction;patient population;patient privacy;Patients;personalized management;personalized predictions;personalized risk prediction;Population;precision medicine;predictive modeling;Procedures;programs;Registries;Research;Research Activity;Research Proposals;Risk;Risk Estimate;Risk Factors;risk prediction;risk prediction model;Site;Source;Specimen;Statistical Algorithm;Statistical Methods;study population;supervised learning;System;Target Populations;Testing;TNF gene;tool;Training;transfer learning;Translational Research;treatment response;user-friendly;Validation

PROJECT_TITLE: Semi-supervised Approaches to Denoising Electronic Health Records Data for Risk Prediction

STUDY_SECTION: BLR

STUDY_SECTION_NAME: Biomedical Informatics, Library and Data Sciences Review Committee[BLR]


PHR: This U19 project proposes a tightly integrated program of theoretical and experimental studies focused on elucidating the neural mechanisms and circuits that mediate causal inference, a fundamental process by which the brain infers the events in the world that give rise to sensory input. Recent studies have suggested that behavioral deficits in schizophrenia or autism spectrum disorders may have their basis in dysfunction of causal inference. Thus, revealing the currently unknown mechanisms of causal inference will ultimately inform treatment of these disorders.

PI_NAMEs: DEANGELIS, GREGORY C (contact)

PROGRAM_OFFICER_NAME: DAVID, KAREN KATE

PROJECT_TERMS: Administrative Coordination;Advisory Committees;Animals;Area;autism spectrum disorder;Back;Bayesian Modeling;Behavior;Behavioral;Belief;Biological Models;Brain;Brain region;Chemicals;Code;Communication;Communities;control theory;Data;data analysis pipeline;Data Science;Data Science Core;data sharing;data standards;Decision Making;density;Disease;Event;Experimental Designs;experimental study;Feedback;Foundations;Functional disorder;Goals;Institution;Location;Macaca;Maps;Mediating;Modeling;Monkeys;Motion;Mus;neural;neural circuit;neural correlate;Neural Pathways;neural patterning;neuromechanism;Neurons;object motion;object perception;optic flow;optogenetics;Parietal;Pattern;Perception;Physics;Population;Positioning Attribute;predictive modeling;Prefrontal Cortex;Procedures;Process;programs;Reporting;Research;Research Support;response;Retina;Role;Schizophrenia;sensorimotor system;Sensory;sensory input;Signal Transduction;Structure;synergism;Testing;Theoretical Studies;theories;Time;tool;Training;United States National Institutes of Health;Update;Work

PROJECT_TITLE: Neural Basis of Causal Inference: Representations, Circuits, and Dynamics


ORG_CITY: Aurora

ORG_NAME: VA EASTERN COLORADO HEALTH CARE SYSTEM

ORG_STATE: CO

PHR: Veterans have the greatest risk of death by suicide immediately following psychiatric hospitalization. Despite hospitalization being a vital time for intervention, there are no suicide-specific research-supported psychotherapies that can be feasibly delivered during a typical VHA inpatient stay. Our research over the past several years has been focused on Acceptance and Commitment Therapy (ACT) as a psychosocial intervention well suited to both preventing suicide and enhancing functioning. The current study will determine whether a brief ACT intervention can enhance recovery after hospitalization for suicide risk and prevent suicidal behavior in the year following inpatient hospitalization. We will determine if benefits are due specifically to ACT, by comparing ACT to Present Centered Therapy. If ACT is found to be efficacious, it will be the first and only evidence-based psychotherapy for Veteran inpatients known to prevent suicidal behavior.

PI_NAMEs: BARNES, SEAN  (contact)

PROJECT_TERMS: acceptability and feasibility;Acute;Address;Ambulatory Care;arm;Behavior;brief intervention;Clinical;Clinical Trials;community reintegration;Data;design;Diagnostic;distress tolerance;efficacy evaluation;efficacy testing;efficacy trial;Emotions;Esthesia;evidence base;Evidence based treatment;Exercise;feasibility trial;flexibility;functional improvement;Future;Goals;high risk;hospital readmission;Hospitalization;Hour;improved;Individual;inpatient psychiatric settings;inpatient psychiatric treatment;inpatient service;Inpatients;Interruption;Intervention;Learning;Life;Literature;Maintenance;Manuals;Medical Records;Mental Health;Metaphor;mortality risk;Outcome;Outpatients;Participant;Pathway interactions;patient engagement;Patients;Pilot Projects;Population;prevent;Process;protective factors;psychiatric inpatient;Psychiatric therapeutic procedure;psychologic;Psychoses;psychosocial;Psychotherapy;Questionnaires;Randomized;randomized controlled design;Randomized, Controlled Trials;Recovery;Recovery of Function;reduce symptoms;reducing suicide;rehabilitation research;Reporting;Research;research and development;Research Personnel;Research Project Grants;research study;Research Support;Risk Reduction;Severities;Site;skills;suicidal;suicidal behavior;suicidal morbidity;suicidal risk;Suicide;Suicide attempt;Suicide prevention;Testing;Therapeutic Intervention;Thinking;Time;treatment as usual;Treatment Protocols;Value of Life;verbal;Veterans

PROJECT_TITLE: Testing the Efficacy of ACT for Life: A Brief Inpatient Intervention to Maximize Recovery and Prevent Future Suicidal Behavior

STUDY_SECTION_NAME: Behavioral Health & Social Reintegration[RRD4]


NIH_SPENDING_CATS: Neurosciences

PROJECT_TITLE: Administrative


ORG_CITY: BEDFORD

ORG_NAME: EDITH NOURSE  ROGERS MEMORIAL VETERANS HOSPITAL

PHR: The Veteran community continues to feel the impact of the US overdose crisis, and opioid use disorder (OUD) diagnoses among Veterans continue to rise. Buprenorphine treatment is critical for preventing relapse and reducing overdose risk, but medications and existing psychotherapy approaches fall short in addressing the consequences of impaired psychosocial functioning during early treatment. Behavioral interventions that focus on recovery-oriented outcomes including interpersonal functioning and community integration are a promising avenue for supporting Veterans during the high-risk period of early treatment. The current CDA-2 proposal would also provide the candidate with necessary skills and expertise to pursue a VA research career focused on improving treatments for Veterans with OUD. Clinical researchers who center Veteran priorities in addiction treatment are valuable assets for a system already committed to delivering person-centered, evidence-based, innovative care.

PI_NAMEs: AMERAL, VICTORIA  (contact)

PROJECT_TERMS: acceptability and feasibility;addiction;Address;Adherence;alcohol use disorder;Area;Award;behavior change;Behavior Therapy;Behavioral Model;Buprenorphine;buprenorphine treatment;career;Career Choice;Caring;Clinical;clinical center;Clinical Research;clinical trial analysis;Communities;Community Integration;community reintegration;comparison intervention;Conduct Clinical Trials;Control Groups;craving;Data;design;Development;Diagnosis;Early treatment;Education;Employment;evidence base;Evidence based intervention;Exercise;Expectancy;experience;experimental study;Face;Family Relationship;Feedback;Fellowship;field study;Foundations;Goals;high risk;housing instability;Impairment;improved;innovation;Interpersonal Relations;Intervention;intervention effect;intervention refinement;Intervention Studies;Interview;K-Series Research Career Programs;Knowledge;Leadership;Link;long term recovery;Manuals;Measures;medication for opioid use disorder;Medication Management;Mental disorders;Mentors;Mentorship;methadone clinic/center;Methodology;model development;Modeling;mortality;motivated behavior;New England;non-opioid analgesic;novel;novel strategies;opioid use disorder;Outcome;Overdose;Overdose reduction;overdose risk;Patients;person centered;Pharmaceutical Preparations;Phase;Pilot Projects;Population;Positioning Attribute;primary outcome;Procedures;Process;Productivity;programs;Protocols documentation;Provider;Psychologist;psychosocial;Psychotherapy;Qualitative Methods;Quality of life;Randomized;Randomized, Controlled Trials;Recommendation;Recovery;Recovery of Function;recruit;relapse prevention;Research;Research Personnel;Role;Sampling;satisfaction;secondary outcome;Self Efficacy;Series;Site;skills;standard care;standard of care;Statistical Data Interpretation;substance use;Substance Use Disorder;Symptoms;System;Therapeutic Intervention;therapy design;therapy development;Time;Training;treatment adherence;treatment as usual;Unemployment;United States National Institutes of Health;Veterans;Work

PROJECT_TITLE: A Brief Values Intervention to Support Veterans in Early Buprenorphine Treatment


NIH_SPENDING_CATS: Bioengineering;Data Science;Networking and Information Technology R&D (NITRD);Neurosciences

PI_NAMEs: DRUGOWITSCH, JAN  (contact)

PROJECT_TERMS: Architecture;Behavioral;Brain;Charge;Code;Collaborations;Communities;computer infrastructure;Computer Models;Computer software;Data;data access;Data Analyses;data cleaning;data exchange;data infrastructure;Data Science Core;Data Scientist;data sharing;data standards;Data Storage and Retrieval;Development;Documentation;Ensure;experience;Experimental Designs;experimental study;Factor Analysis;Future;Goals;improved;Information Technology;Infrastructure;International;invention;Investments;Joints;Label;Laboratories;member;Metadata;Methods;Modeling;Morphologic artifacts;multidisciplinary;Nature;neural;neural model;neuromechanism;neurophysiology;Neurosciences;open source;Population;Principal Component Analysis;Process;Publishing;repository;Reproducibility;Research;Research Personnel;Resources;searchable database;Software Tools;Source Code;Standardization;Statistical Models;Stimulus;Structure;Techniques;Testing;theories;Time;tool;Variant;voltage;Work

PROJECT_TITLE: Data-Science Core


ORG_NAME: LOUIS STOKES CLEVELAND VA MEDICAL CENTER

PHR: Stroke affects upwards of 800,000 Americans every year and has an enormous impact on the well-being of the American veteran population. Many stroke survivors are living with chronic upper limb disability which results in decreased function, increased reliance on caregiver support and poor quality of life. New methods are needed to improve outcome. Currently, motor learning-based therapy has been found to be most effective but its application for those with severe upper limb impairment is challenging due to the individual’s limited ability to move the weakened limb. We propose to evaluate use of MyoPro device to help in motor learning therapy for those with severe upper limb impairment. The MyoPro is a powered upper limb brace that assists movement of the upper limb by using an electrical signal generated by the individual’s muscle to activate motors in the brace. In addition to treatment effect, we will study neuroplastic mechanisms underlying this treatment. The addition of MyoPro may improve outcomes and reduce cost of both rehabilitation and post-stroke care.

PI_NAMEs: PUNDIK, SVETLANA  (contact)

PROJECT_TERMS: 3-Dimensional;Accelerometer;actigraphy;Address;Adherence;Affect;Aftercare;American;arm;arm function;arm movement;arm paresis;biomarker identification;Brain;care costs;Caregiver support;Caring;Chronic;chronic stroke;Clinic;Clinical;clinical practice;Combined Modality Therapy;Corticospinal Tracts;cost;cost effective;cost effectiveness;cost estimate;cost-effectiveness evaluation;Custom;design;Devices;Diffusion Magnetic Resonance Imaging;disability;Dose;Effectiveness;efficacy study;efficacy testing;Electromyography;exoskeleton;Facilities and Administrative Costs;follow-up;functional improvement;Functional Magnetic Resonance Imaging;Future;Goals;grasp;health related quality of life;Health Services Accessibility;Health Surveys;Home;Hour;Impairment;improved;improved outcome;Individual;insight;interest;Intervention;Intervention Studies;Joints;kinematics;Laboratories;Lesion;Limb structure;Magnetic Resonance Imaging;Measures;Methods;military veteran;Motion;Motor;motor deficit;Motor Evoked Potentials;motor impairment;motor learning;Movement;Muscle;Muscle Tonus;Muscle Weakness;Neuronal Plasticity;neurophysiology;novel;novel strategies;Optics;Orthotic Devices;Outcome;Outcome Measure;patient population;Patients;Performance;Personal Satisfaction;Phase;Population Intervention;post stroke;Predictive Factor;primary outcome;Proprioception;Protocols documentation;Quality of life;Randomized;Randomized, Controlled Trials;recruit;Rehabilitation therapy;Research;Research Design;response;Rest;rural area;secondary outcome;Sensory;Signal Transduction;Stroke;stroke rehabilitation;stroke survivor;Structure;Surveys;System;Testing;therapeutic effectiveness;Time;Training;Translating;treatment effect;treatment group;treatment response;United States Department of Veterans Affairs;Upper Extremity;Upper limb movement;Veterans;wearable device;white matter

PROJECT_TITLE: Exoskeleton Research: Myoelectric orthosis for rehab of severe chronic arm motor deficits


ORG_CITY: MIAMI

ORG_NAME: MIAMI VA HEALTH CARE SYSTEM

PHR: The research focuses on the unmet clinical need to develop therapeutic approaches for residual hearing preservations in veterans receiving cochlear implantation, so that they may benefit fully from these neuroprosthetic devices. These studies are critical for the rehabilitation of our veterans as noise- and blast-induced hearing loss are the most prevalent disability and service members report significant hearing threshold shifts. We will generate new knowledge of the pathophysiology and safety and efficacy of hypothermia as a therapeutic approach from a preclinical model with a goal to bring the therapy to market to benefit our veterans eligible to receive cochlear implantation.

PI_NAMEs: RAJGURU, SUHRUD M. (contact)

PROJECT_TERMS: Acoustics;Acute;Anatomy;Audiology;Auditory;Auditory Threshold;auditory threshold shift;blast exposure;Blood Vessels;Chronic;Clinical;clinical translation;Cochlea;Cochlear implant procedure;Cochlear Implants;Communication;cost;Data;design;Deterioration;Development;Devices;disability;efficacy testing;Electric Stimulation;Eligibility Determination;Environment;Experimental Models;Exposure to;Frequencies;Functional disorder;ganglion cell;Goals;Hair Cells;Hearing;hearing impairment;hearing preservation;Hearing problem;Histologic;histological studies;Hour;Implant;implantable device;implantation;improved;Inflammation;Injury;Intervention;Knowledge;Labyrinth;Link;Maintenance;Marketing;Measurement;Mechanics;middle ear;military service;Modality;Modeling;natural hypothermia;neural;Neurons;neuroprosthesis;Noise;noise exposure;Noise-Induced Hearing Loss;normal hearing;novel;Operative Surgical Procedures;Organ of Corti;Otologic Surgical Procedures;Outcome;Outer Hair Cells;Oxidative Stress;Pathology;Patients;Phenotype;Physiological;pre-clinical;Pre-Clinical Model;preservation;presynaptic;prevent;Protocols documentation;Publishing;Rattus;Rehabilitation therapy;Reporting;Research;Residual state;Rewarming;ribbon synapse;Risk;Rodent Model;Safety;Sensorineural Hearing Loss;Sensory;Sensory Hair;service member;Services;Speech;Speech Perception;speech recognition;spiral ganglion;Structure;Surgical Injuries;surgical risk;Synapses;Synaptic Vesicles;Temperature;Temporary Threshold Shift;Testing;Therapeutic;Therapeutic Intervention;therapy duration;Time;translational therapeutics;Trauma;treatment optimization;Treatment Protocols;Tube;Veterans;Work

PROJECT_TITLE: Therapeutic hypothermia to preserve residual hearing in veterans receiving cochlear implantation

STUDY_SECTION_NAME: Sensory Systems & Communication Disorders[RRD3]