NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Infectious Diseases;Rare Diseases;Tuberculosis

PI_NAMEs: TURNER, JOANNE  (contact)

PROJECT_TERMS: Address;Applications Grants;Award;Biomedical Research;career;career development;Clinic;Clinical;Clinical Management;commercialization;Communication;Communities;community engagement;Complement;Complex;Data;design;Detection;Development;Discipline;Education;Eligibility Determination;experience;Exposure to;Funding;Funding Agency;Goals;Grant;Health Professional;Human;Individual;Infectious disease threat;Interdisciplinary Study;Internships;Knowledge;Laboratories;learning progression;Mission;multidisciplinary;new technology;next generation;Participant;peer;prevent;Prevention;product development;programs;prospective;Public Health;Research;Research Institute;Research Personnel;Schedule;Science;Site;skills;Structure;success;Talents;Texas;tool;Training;Training Programs;Tuberculosis;Work;Writing

PROJECT_TITLE: Developmental Core


ADMINISTERING_IC: AI

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Biodefense and Related Countermeasures;Bioengineering;Data Science;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Influenza;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pneumonia and Influenza;Prevention;Social Determinants of Health

ORG_CITY: NEW HAVEN

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_FIPS: US

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative We will develop innovative algorithms for detecting emerging respiratory viruses within US cities. To do so, we will model the syndemic dynamics of respiratory viruses and chronic respiratory diseases and apply machine learning to combine geospatial data that track early indicators of emerging threats. Working with local public health and healthcare collaborators, we will translate this research into practical tools for addressing socio- geographic gaps in surveillance and accelerating the detection, prevention and mitigation of severe outbreaks.

PI_NAMEs: GALVANI, ALISON P (contact);MEYERS, LAUREN ANCEL

PROGRAM_OFFICER_NAME: BOZICK, BROOKE ALLISON

PROJECT_TERMS: Absenteeism;Acceleration;access disparities;Address;African;Age;Algorithm Design;Algorithms;Area;Articulation;Bayesian Method;Behavioral;Caring;Chronic;Chronic Disease;chronic respiratory disease;Cities;Climate;Clinical;Clinical Data;cofactor;Collaborations;comorbidity;dashboard;Data;data acquisition;data handling;data integration;Data Sources;Decision Making;design;Detection;detection method;detection platform;digital;Disease;disease model;Disease Outbreaks;Disease Surveillance;disease transmission;diverse data;Ebola;Electronic Health Record;electronic health record system;emerging virus;Ensure;Epidemic;epidemiologic data;epidemiological model;Evaluation;experimental study;flexibility;Geography;global health;Goals;Health;health care availability;health goals;Healthcare;high risk;high risk population;Home;Human;improved;Individual;Infection;Infectious disease threat;Influenza;Influenza A Virus, H1N1 Subtype;influenza outbreak;influenzavirus;innovation;insight;Interdisciplinary Study;International;Internet;Intervention;Location;Machine Learning;Medical;Methodology;Methods;metropolitan;Mexico;Modeling;Neighborhoods;new outbreak;next generation;novel;Outcome;pandemic disease;Pollution;Population;Prevention;Proliferating;Public Health;public health intervention;Pythons;Readiness;Reporting;Research;Resolution;Respiratory Disease;respiratory virus;Risk;Rural;school district;Schools;Seasons;Sentinel;Series;signal processing;Signal Transduction;simulation;Social Environment;social media;sociodemographic group;socioeconomics;sound;spatiotemporal;Specific qualifier value;Speed;stem;Subgroup;Surveillance Modeling;Symptoms;syndemic;System;Techniques;Testing;Time;tool;Translating;transmission process;trend;Uncertainty;underserved community;user-friendly;Validation;Viral;viral outbreak;viral transmission;Virus;Virus Diseases;Visualization;Work;World Health Organization

PROJECT_TITLE: Accelerating viral outbreak detection in US cities using mechanistic models, machine learning and diverse geospatial data

STUDY_SECTION: IRAP

STUDY_SECTION_NAME: Infectious Diseases, Reproductive Health, Asthma and Pulmonary Conditions Study Section[IRAP]


FUNDING_MECHANISM: RESEARCH CENTERS

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Rare Diseases;Tuberculosis

ORG_CITY: SAN ANTONIO

ORG_NAME: TEXAS BIOMEDICAL RESEARCH INSTITUTE

ORG_STATE: TX

PI_NAMEs: TORRELLES, JORDI B (contact)

PROJECT_TERMS: Accidents;Address;Aerosols;Antibiotics;Basic Science;biocontainment facility;Bioenergetics;Biomedical Research;biosafety level 3 facility;Blood;career;Cell Separation;cellular imaging;Clinical;co-infection;Containment;cytate;Decontamination;design;Drug resistant Mycobacteria Tuberculosis;Educational Curriculum;Electron Spin Resonance Spectroscopy;Emergency response;Emergency Situation;Emerging Technologies;Ensure;Environment;Equipment;experience;experimental study;Genomics;Genus Hippocampus;Goals;hazard;Immunohistochemistry;In Vitro;in vivo;in vivo imaging system;Infection;Infectious Agent;innovation;Knowledge;knowledgebase;Laboratories;laboratory experience;Learning;Maintenance;man-made disasters;Measures;Medical emergency;Metabolic;Methods;microscopic imaging;multidisciplinary;Mycobacterium tuberculosis;Mycobacterium tuberculosis complex;new technology;next generation;nonhuman primate;operation;Oral;Participant;personal protective equipment;PET/CT scan;Phase;Predisposition;Procedures;programs;Research;Research Institute;Research Personnel;Resource-limited setting;response;Risk;Risk Assessment;risk mitigation;Rodent;Safety;single-cell RNA sequencing;skills;Source;success;Techniques;Texas;Training;Training Programs;Training Technics;Tuberculosis;Work;Writing;X-Ray Computed Tomography

PROJECT_TITLE: Basic Science Core - Biosafety & Biocontainment Core (BBC)


ADMINISTERING_IC: OD

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

ORG_CITY: MANHATTAN

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: KANSAS STATE UNIVERSITY

ORG_STATE: KS

PHR: Project Narrative There is a pressing critical national need for veterinarians to be engaged in biomedical research to enhance, promote and sustain public health. Veterinarians are uniquely trained as comparative biologists to assess patient health in the context of multiple and variable environmental situations and are therefore well suited to meet these societal needs. The Veterinary Research Scholars Program provides select talented students with intensive research experience directed towards attracting veterinary students into biomedical research careers.

PI_NAMEs: KUKANICH, KATE STENSKE;SCHULTZ, BRUCE D (contact)

PROGRAM_OFFICER_NAME: TANDON, RITESH

PROJECT_TERMS: Advisory Committees;Advocate;Area;biomedical scientist;Breathing;career;Cell Physiology;comparative;Disease;Educational process of instructing;Educational workshop;Ensure;experience;Faculty;faculty research;Funding;Goals;Health;Health Professional;Immunity;Infection;International;Journals;Laboratories;Leadership;Learning;Medicine;Mentors;model organism;Peer Review;Pharmacology;Physiology;Policy Developments;programs;Public Health;Public Policy;Publishing;Qualifying;Recruitment Activity;Request for Applications;Research;Research Design;Research Ethics;research facility;Research Personnel;research study;Research Training;Scholars Program;Schools;Science;Students;Study Skills;success;summer research;symposium;Talents;tool;Training;Training Programs;Translational Research;United States Department of Agriculture;United States National Institutes of Health;Veterinarians;Work;Writing

PROJECT_TITLE: Short Term Training in Health Professional Schools


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Lung;Orphan Drug;Rare Diseases;Tuberculosis

PI_NAMEs: HALL-URSONE, SHANNAN  (contact)

PROJECT_TERMS: Address;Animal Experimentation;Animal Model;Animals;Basic Science;biocontainment facility;Biomedical Research;Chest;Cities;Clinic;Clinical;Clinical Management;Clinical Services;Communicable Diseases;Communication;Communities;Complement;Country;Data;design;Development;Discipline;Drug Screening;Ebola;Education;experience;Experimental Designs;externship;Foundations;Funding Agency;Health;Health Professional;Hepatitis Viruses;HIV;Human;imaging platform;in silico;In Vitro;Infectious disease threat;Inpatients;Knowledge;Leadership;metropolitan;Mexico;Mission;Modeling;Molecular Biology;mouse model;multidisciplinary;Mus;next generation;nonhuman primate;novel therapeutics;novel vaccines;Outpatients;Participant;Pathogenesis;peer;Pertussis;prevent;Primates;programs;prospective;Publishing;Research;Research Institute;Research Personnel;Resources;Rodent;Science;skills;Structure;success;System;Testing;Texas;theories;tool;Training;Training Programs;Translating;Tuberculosis;Tuberculosis Vaccines;Universities;Work;ZIKA

PROJECT_TITLE: Basic Science Core - Animal models


ADMINISTERING_IC: EY

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: BOSTON

ORG_DEPT: PSYCHOLOGY

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

ORG_STATE: MA

PHR: PROJECT NARRATIVE This project will investigate how inhibitory and excitatory neural computations influence basic responses in human visual cortex, as well as how these computations work in concert with attention to selectively enhance perception. The results will inform models of the human visual system, which provide a necessary framework for the development of diagnostic tools and treatments for clinical disorders that involve deficits of central visual processing. Moreover, the studies of visual attention will further inform the development of diagnostic tests and interventions for attention-related disorders.

PI_NAMEs: LING, SAM  (contact)

PROGRAM_OFFICER_NAME: WIGGS, CHERI

PROJECT_TERMS: Attention;attentional modulation;Automobile Driving;Bioenergetics;Brain;Characteristics;Clinical Treatment;Code;cognitive process;Computer Models;Consensus;cost;Development;diagnostic development;Diagnostic tests;diagnostic tool;Disease;Equilibrium;Event;experimental study;flexibility;Foundations;Frequencies;Functional Magnetic Resonance Imaging;Funding;Goals;Human;innovation;Intervention;Knowledge;Measures;Methods;Modeling;Nature;neural;neuroimaging;neuromechanism;neuroregulation;Neurosciences;novel;Perception;Play;Population;Population Control;preference;prevent;Process;Property;Public Health;Regulation;Research Personnel;response;Role;segregation;selective attention;Sensory;Shapes;signal processing;Stimulus;Techniques;Testing;theories;tool;Vision;Visual;Visual attention;Visual Cortex;visual processing;Visual System;Work

PROJECT_TITLE: How Does Normalization Regulate Visual Competition?

STUDY_SECTION: HCMF

STUDY_SECTION_NAME: Human Complex Mental Function Study Section[HCMF]


ADMINISTERING_IC: CA

ED_INST_TYPE: HOSPITALS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Biomedical Imaging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Dissemination and Implementation Research;Health Services;Nutrition;Patient Safety;Rare Diseases

ORG_CITY: HOUSTON

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: NARRATIVE Difficulty swallowing (dysphagia) is common in cancer survivors with significant burden on individuals (causing diet restrictions, feeding tubes, choking, pneumonia, death), their caregivers (requiring special food preparation, eating alone, isolation, fear), and the healthcare system (increasing length of stay, medical costs, resource utilization). Effective evaluation using evidence-based metrics in real-world clinical care is the first step in high- quality dysphagia management. This project proposes to apply dissemination and implementation science to help speech-language pathologists improve cancer survivors’ outcomes through adoption of DIGEST™ (Dynamic Imaging Grade of Swallowing Toxicity) as an EBP tool for swallowing diagnostics in real-world clinical practice.

PI_NAMEs: HUTCHESON, KATHERINE ARNOLD (contact)

PROGRAM_OFFICER_NAME: MITCHELL, SANDRA A

PROJECT_TERMS: Address;Adopted;Adoption;Adverse event;Affect;Agreement;arm;aspirate;Aspiration Pneumonia;Barium swallow;Bolus Infusion;cancer care;Cancer Survivor;Cancer Survivorship;care outcomes;Caregivers;Caring;Cessation of life;Characteristics;Choking;Clinic;Clinical;clinical care;clinical decision-making;clinical practice;Clinical Practice Variations;Clinical Trials;Collection;Common Terminology Criteria for Adverse Events;Consolidated Framework for Implementation Research;contextual factors;daily functioning;Data;Data Set;Decision Trees;Deglutition;Deglutition Disorders;design;Development;Diagnostic;dietary restriction;Dissemination and Implementation;dissemination science;Dose;Eating;Effectiveness;effectiveness evaluation;Enteral Feeding;Environment;Esophagus;Evaluation;evidence base;Evidence based practice;Exercise;Focus Groups;Food;food preparation;Frequencies;Fright;functional status;Funding;Goals;Head and Neck Cancer;Health;Health system;Healthcare Systems;Image;implementation science;implementation strategy;improved;Individual;Injury;Institution;International;Knowledge;Language;Length of Stay;life span;Liquid substance;Malignant Neoplasms;Malnutrition;Measurement;Measures;Medical;Medical Care Costs;Methodology;Methods;mortality;mortality risk;Muscle;National Cancer Institute;Oncology;Outcome;Outcome Measure;Pathologist;Patient-Focused Outcomes;Pattern;Penetration;personalized care;Pharyngeal structure;Physiological;Pneumonia;Population;Population Heterogeneity;Prevalence;programs;Protocols documentation;Psychometrics;Publishing;Quality of life;Radiation Dose Unit;radiological imaging;Randomized;Reporting;Reproducibility;Research;Research Peer Review;Research Personnel;research to practice;Resources;response;routine practice;Safety;scale up;secondary analysis;Services;Severities;Site;Speech;Structure;Supportive care;Surveys;Time;tool;Toxic effect;Training Programs;Uncertainty;United States;uptake;Validation;Work

PROJECT_TITLE: Dissemination and implementation of DIGEST™ as an evidence-based measurement tool for dysphagia in cancer

STUDY_SECTION: MFSR

STUDY_SECTION_NAME: Motor Function, Speech and Rehabilitation Study Section[MFSR]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biomedical Imaging;Emerging Infectious Diseases;Infectious Diseases;Rare Diseases;Tuberculosis

PI_NAMEs: KAUSHAL, DEEPAK  (contact)

PROJECT_TERMS: Address;Animal Model;animal safety;Animals;Basic Science;biocontainment facility;Biology;Biomedical Research;Caring;Cell Separation;Cells;Cellular Immunology;Cities;Clinical;Clinical Management;Clinical Services;cohort;Collaborations;Communication;Communities;Complement;Computational algorithm;Computer Analysis;confocal imaging;Confocal Microscopy;Containment;cytate;Data;design;Disadvantaged;Discipline;Educational Curriculum;Equipment;Evaluation;experience;Experimental Designs;Flow Cytometry;Fluorescent in Situ Hybridization;Fluorochrome;Freezing;Funding;Funding Agency;Genomics;Goals;Health Professional;high dimensionality;Image;Image Analysis;imaging capabilities;imaging modality;imaging platform;imaging study;Immunofluorescence Immunologic;in vivo imaging system;Inpatients;Institution;Knowledge;Label;Laboratories;Lasers;Leadership;Learning;Light;live cell imaging;Magnetic Resonance Imaging;Mexico;microscopic imaging;Microscopy;Molecular;multidisciplinary;next generation;optical imaging;Optics;Outpatients;Paraffin;Participant;peer;Positron-Emission Tomography;prevent;Primates;programs;prospective;Publishing;Recording of previous events;Research;Research Institute;Research Personnel;Resources;RNA;Robotics;Rodent;Science;Scientist;Services;single-cell RNA sequencing;skills;Sorting;Structure;System;Techniques;Testing;Texas;Thick;Tissues;tomography;tool;Training;Training Programs;Tuberculosis;United States National Institutes of Health;whole animal imaging;Work;X-Ray Computed Tomography

PROJECT_TITLE: Basic Science Core - Imaging


ADMINISTERING_IC: MD

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: LITTLE ROCK

ORG_NAME: UNIV OF ARKANSAS FOR MED SCIS

ORG_STATE: AR

PHR: PROJECT NARRATIVE The proposed Stage 3 efficacy study aims to inform health policy by testing a novel intervention that directly reduces the racial income gap by providing a universal basic income (UBI), which is intended to promote and protect Black men's health through the influx of capital and subsequent increases in personal agency and social connections. We hypothesize that (1) providing UBI of $500 per month for six months will result in increased healthcare utilization among chronically-ill, older and aging, low-income Black men; and (2) the effect of UBI will depend on whether an individual has a recent history of incarceration, such that no incarceration history combined with UBI will demonstrate the best study outcomes. Empirical research examining UBI among older Black men and its capacity to overturn structural racism are lacking in the extant literature—much of the health disparities research intended to inform health and economic policy originated from limited perspectives of older and aging Black men—Dr. W.E.B. Du Bois said in The Souls of Black Folk that for Black people, “discouragement is an unwritten word”; this study draws on that inspiration as it ultimately seeks to fundamentally overturn the economic oppression and brutality that has defined the Black experience for generations.

PI_NAMEs: MONTGOMERY, BROOKE E.E. (contact)

PROGRAM_OFFICER_NAME: STINSON, NATHANIEL

PROJECT_TERMS: Accounting;Address;Affect;African American;Aging;Area;behavioral health;black men;Black Populations;Black race;Breathing;Capital;Caring;Chronic;Chronic Disease;Chronically Ill;Communities;Community Health;Complex;Correctional Institutions;design;Discrimination;Disease;Economic Policy;Economics;Education;efficacy study;Emotional;Empirical Research;Ensure;Epidemiology;experience;Family;Financial Hardship;Generations;Geography;Health;Health behavior;health care availability;health care service;health care service utilization;health difference;Health Disparities Research;Health Policy;health service use;Healthcare Systems;HIV;Imprisonment;Income;Individual;Intervention;Justice;Literature;Low income;low socioeconomic status;male health;Marketing;men;Methods;Minority Groups;novel;Outcome Study;Overdose;Perception;Pharmaceutical Preparations;physical conditioning;Police;Policies;population health;Poverty;protective factors;Race;racial disparity;racial health disparity;Racial Segregation;recidivism;Recording of previous events;Recurrence;reincarceration;Research;residence;Resources;Risk;Role;segregation;social;Structural Racism;Testing;Time;transmission process;Trauma;United States;Wages;Writing

PROJECT_TITLE: Universal basic income and structural racism in the US South: Differences in health service utilization between older African American men with and without experiences of recent incarceration


ADMINISTERING_IC: LM

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Coronaviruses;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: SEATTLE

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Deep neural transformer networks have advanced Natural Language Processing (NLP) performance, but are large models with many parameters, and hence vulnerable to bias. The large data sets required to train these models may be drawn from different study sites or clinical units, leading to confounding by provenance where models make predictions using the characteristics of these data sources instead of diagnostically relevant information, with erroneous predictions at the point of deployment. In the proposed research we will develop validated approaches for Deconfounding Deep Transformer Networks (DecondDTN) and disseminate them as open source tools so that these models can be applied more reliably to clinical problems.

PI_NAMEs: COHEN, TREVOR  (contact);PAKHOMOV, SERGUEI VS

PROGRAM_OFFICER_NAME: REDDY, GOUTHAM

PROJECT_TERMS: Address;Architecture;Area;artificial intelligence method;Automobile Driving;Behavior;Bridge to Artificial Intelligence;Caring;Categories;Characteristics;Classification;Clinical;Clinical Services;Cognitive;Computer software;Confounding Factors (Epidemiology);Coupled;COVID-19;COVID-19 prevalence;Data;Data Aggregation;Data Set;Data Sources;deep learning;deep learning model;Dementia;design;Development;Diagnosis;Diagnostic;Ensure;Equilibrium;Evaluation;explainable artificial intelligence;Genetic Transcription;Goals;heterogenous data;High Prevalence;Individual;Institution;interest;Investments;Label;Language;large datasets;Learning;Linguistics;Location;loss of function;machine learning model;Medical;Methods;Modeling;Modification;Natural Language Processing;Nature;network models;neural;Neural Network Simulation;novel;open source;open source tool;Outcome;Output;Participant;Patients;Performance;Physicians;portability;predictive modeling;programs;Research;Sampling;SARS-CoV-2 positive;Services;Site;Source;Speech;statistical and machine learning;Systematic Bias;Testing;Text;Time;Training;training data;Transcript;United States National Institutes of Health;United States National Library of Medicine;Update;Vision;Weight;Work

PROJECT_TITLE: DeconDTN: Deconfounding Deep Transformer Networks for Clinical NLP

STUDY_SECTION: BLR

STUDY_SECTION_NAME: Biomedical Informatics, Library and Data Sciences Review Committee[BLR]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Infectious Diseases;Lung;Patient Safety;Rare Diseases;Tuberculosis

PI_NAMEs: SCHLESINGER, LARRY S. (contact)

PROJECT_TERMS: Address;Ambulatory Care Facilities;biocontainment facility;Biomedical Research;Caring;Cause of Death;Chest;Cities;Clinic;Clinical;clinical care;clinical center;Clinical Management;Clinical Research;clinical research site;Clinical Services;Collection;Communicable Diseases;Communication;Communities;comorbidity;Complex;Consultations;Country;critical period;curriculum enhancement;Data;Data Analyses;design;Development;Diabetes Mellitus;diagnostic strategy;Discipline;Education;Educational Curriculum;Epidemiology;Ethics;Evaluation;experience;Extreme drug resistant tuberculosis;field study;Field Workers;Foundations;Funding;Funding Agency;Future;Health;Health Professional;Homelessness;Hospitals;human old age (65+);Human Subject Research;Hybrids;improved;Incidence;Infectious disease threat;Infrastructure;Inpatients;Institution;interdisciplinary approach;interdisciplinary curriculum;interest;Knowledge;Laboratories;laboratory experiment;Leadership;Learning;Length of Stay;Logistics;Medical;member;Mentors;metropolitan;Mexican;Mexico;Mission;multidisciplinary;Multidrug-Resistant Tuberculosis;next generation;Non-Insulin-Dependent Diabetes Mellitus;Oral;Outpatients;Participant;participant enrollment;Pathogenesis;Patient Care;Patients;peer;Persons;Physicians;Pilot Projects;Population;prevent;Prevention strategy;programs;prospective;Qualitative Evaluations;Quantitative Evaluations;Research;Research Design;Research Institute;Research Personnel;research study;Research Training;Resources;Rotation;Science;Side;Site;skills;social;Social Problems;South Texas;Specimen;Specimen Handling;Structure;success;Texas;therapy adverse effect;Thoracic Radiography;tool;Training;transmission process;Treatment outcome;treatment strategy;Tuberculosis;tuberculosis diagnostics;tuberculosis treatment;Universities;Vaccines;virtual;Work;Writing

PROJECT_TITLE: Clinical Research & Patient Care Core (CRPCC)


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurosciences;Sleep Research

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: Project Narrative  The ventrolateral preoptic (VLPO) nucleus is a key brain area for the generation and the maintenance of sleep, and the extended VLPO region (eVLPO) contains neurons that are active during REM sleep and are REM sleep-promoting. The purpose of this project is to define the long-range circuit basis by which the eVLPO controls REM sleep. Successful completion of the proposed research will contribute to a better understanding of the role of the preoptic region within the circuits for REM sleep regulation.

PI_NAMEs: DE LUCA, ROBERTO  (contact)

PROGRAM_OFFICER_NAME: HE, JANET

PROJECT_TERMS: anatomical tracing;Animals;Applications Grants;Area;Automobile Driving;Axon;base;Brain;Brain Stem;Cell Nucleus;Cells;Data;design;Disinhibition;Dorsal;Electrophysiology (science);experimental study;follow-up;Follow-Up Studies;Future;Galanin;gamma-Aminobutyric Acid;Generations;Genetic;Genetic Transcription;Goals;Grant;In Situ Hybridization;In Vitro;in vivo;insight;interest;Knowledge;Label;Lesion;locus ceruleus structure;Maintenance;Maps;Medial;Mediating;Methods;midbrain central gray substance;Midbrain structure;Mus;neural circuit;Neurons;Neuropeptides;Neurotensin;non rapid eye movement;novel;Optics;optogenetics;Output;Pathway interactions;Pontine structure;Population;postsynaptic;postsynaptic neurons;Preoptic Areas;preoptic nucleus;Process;public repository;REM Sleep;Research;Research Project Grants;response;Reticular Formation;Role;secondary analysis;selective expression;single-cell RNA sequencing;Sleep;sleep regulation;Sleeplessness;Slice;Synapses;Testing;Time;tool;transcriptomics;Work

PROJECT_TITLE: The Role of Neurotensin-Expressing Neurons of the Extended Ventrolateral Preoptic Nucleus in REM Sleep Regulation

STUDY_SECTION: BNRS

STUDY_SECTION_NAME: Behavioral Neuroendocrinology, Neuroimmunology, Rhythms, and Sleep Study Section [BNRS]


ADMINISTERING_IC: EB

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: CAMBRIDGE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

PHR: We will combine synthetic biology and advanced computational techniques to accelerate an ongoing revolution — the application of human induced pluripotent stem cells (hiPSCs) to regenerative and personalized medicine. We will integrate new genetic circuits into hiPSCs that sense changes in endogenous gene expression and activate expression of other genes in order to redirect organoid differentiation to desired outcomes with specific 3D organization and arrangements of cell types and functions. Our design of sophisticated gene regulatory networks will be based on advanced optimization techniques rooted in control theory and machine learning, enabling precise and predictable generation of desired 3D structures and organoid functions.

PI_NAMEs: BELTA, CALIN ;KEMP, MELISSA LAMBETH;WEISS, RON  (contact)

PROGRAM_OFFICER_NAME: FEHR, TUBA HALISE

PROJECT_TERMS: 3-Dimensional;Acceleration;Blood Vessels;Cadherins;Calibration;Cell Communication;Cell Differentiation process;Cell Physiology;cell type;Cells;Classification;Communication;Complex;Computational Technique;Computer Models;Computer Simulation;computing resources;control theory;design;Development;Developmental Process;Drug Screening;Endoderm;Engineering;engineering design;extracellular;Feedback;Gene Expression;gene regulatory network;Generations;Genes;Genetic;Genetic Transcription;Growth Factor;Guide RNA;Hematopoiesis;human induced pluripotent stem cells;Image;Individual;induced pluripotent stem cell;information processing;innovation;insight;Investigation;Liver;Logic;Machine Learning;mathematical model;Mesoderm;Methods;Modeling;Monitor;operation;Organoids;Outcome;Output;Pattern;personalized medicine;Phenotype;Play;Population;precision drugs;Probability;Process;programs;Property;Proteins;Protocols documentation;Psychological reinforcement;Regenerative Medicine;Reporter;Reporting;Reproducibility;Role;self assembly;self organization;sensor;single-cell RNA sequencing;Specific qualifier value;stem cell organoids;stem cell population;Stromal Cells;Structure;Switch Genes;synthetic biology;Synthetic Genes;System;Techniques;Therapeutic;three dimensional structure;Tissue Engineering;Tissues;tool;Training;Tube;Visual

PROJECT_TITLE: Synthetic gene sensors and effectors to redirect organoid development

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-R(02)M]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Clinical Research;Comparative Effectiveness Research;Cost Effectiveness Research;Infectious Diseases;Patient Safety;Pediatric;Prevention

ORG_CITY: Aurora

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE: This proposal aims to optimize the diagnostic strategy for pediatric musculoskeletal infections (MSKIs). The proposed research will leverage a national database of pediatric hospitals to describe the variable diagnostic approaches and associated clinical outcomes for MSKIs amongst children’s hospitals in the United States and will evaluate the clinical performance and comparative cost of a non-invasive diagnostic strategy for pediatric MSKIs.

PI_NAMEs: SEARNS, JUSTIN BENJAMIN (contact)

PROGRAM_OFFICER_NAME: RITCHIE, ALEC

PROJECT_TERMS: Acute;Address;Agreement;Algorithms;antimicrobial;Award;Biological Testing;Biopsy;Blood;Blood specimen;bone;career;Caring;case finding;cell free DNA;Child;Child Care;Child health care;Childhood;Clinical;clinical care;Code;Collection;Colorado;Communicable Diseases;comparative;Consumption;cost;Cost Analysis;cost comparison;cost estimate;Data;Database Management Systems;Databases;Dedications;Diagnostic;Diagnostic Procedure;diagnostic strategy;Diagnostic tests;Diagnostic Trial;disability;Disease;DNA;Enrollment;Equilibrium;Frequencies;Future;Goals;Guidelines;Health Information System;Hematogenous;hospital readmission;Hospitalization;Hospitals;improved;Infection;innovation;Inpatients;Institution;interest;Interventional radiology;Intravenous;Investigation;Joints;Length;Length of Stay;Life;liquid biopsy;Mentorship;microbial;Microbiological Techniques;Microbiology;microcosting;minimally invasive;Modality;Molecular Diagnostic Testing;Morbidity - disease rate;multidisciplinary;Musculoskeletal;next generation sequencing;noninvasive diagnosis;novel diagnostics;Operative Surgical Procedures;Osteomyelitis;Outcome;pathogen;Pathogen detection;pathogenic bacteria;Patients;Pediatric Hospitals;Performance;peripheral blood;Population;prevent;primary outcome;Procedures;Prospective Studies;Prospective, cohort study;Publishing;Recommendation;Reference Standards;relative cost;Research;Research Personnel;Resources;Risk;sample collection;Sedation procedure;skills;Societies;Source;Specimen;standard of care;standardized care;targeted treatment;Techniques;Testing;Training;United States;Variant

PROJECT_TITLE: Optimizing the Diagnostic Strategy for Acute Musculoskeletal Infections in Children: Evaluating the Clinical Performance and Comparative Cost of a Noninvasive Diagnostic Technique

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases B Research Study Section[MID-B]


ORG_CITY: GAINESVILLE

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Project Narrative We have engineered innovative fusion protein enzyme constructs in tissue-anchored and circulating forms as therapeutics to shut down Th17-driven inflammation through metabolic reprogramming. We are applying these to the inflammatory autoimmune disease psoriasis, which is in need of new clinical options.

PI_NAMEs: AVRAM, DORINA ;KESELOWSKY, BENJAMIN GEORGE (contact)

PROGRAM_OFFICER_NAME: RICE, JEFFREY S

PROJECT_TERMS: Address;Anti-Inflammatory Agents;Autoimmune Diseases;Autoimmune Responses;autoinflammatory;autoinflammatory diseases;autosomal dominant mutation;beta-galactoside;Binding;Biological;carbohydrate binding protein;carbohydrate receptor;Cell Physiology;Cell Reprogramming;cell type;Cells;Chimeric Proteins;Chronic;Circulation;Clinical;cytokine;Data;Diffusion;Disease;Dose;Engineering;enzyme model;Enzymes;Essential Amino Acids;extracellular;Galectin 3;Genes;Glycosaminoglycans;Half-Life;Homeostasis;human model;IL17 gene;Imiquimod;Immune;immune modulating agents;Immune response;Immunocompromised Host;Immunofluorescence Immunologic;immunoregulation;Immunosuppression;Immunotherapeutic agent;Impairment;in vivo;Infection;Inflammation;Inflammatory;innovation;interleukin-17E;interleukin-22;interleukin-23;keratinocyte;Kynurenine;Lymphoid Cell;Maximum Tolerated Dose;Metabolic;Metabolism;mouse model;novel;novel strategies;novel therapeutics;Pathogenicity;Pathology;Patients;Pharmaceutical Preparations;Play;Polysaccharides;Predisposition;Production;programs;Psoriasis;Resolution;response;restoration;Role;Route;side effect;single-cell RNA sequencing;Skin;skin damage;Sterility;Stimulus;success;systemic toxicity;Therapeutic;Tissues;Toxic effect;Translations;Tryptophan;Tryptophan 2,3 Dioxygenase;Tryptophan Metabolism Pathway;γδ T cells

PROJECT_TITLE: Tissue-Anchored vs. Circulating Engineered Enzyme Constructs for Immunometabolic Resolution of Psoriasis

STUDY_SECTION: GDD

STUDY_SECTION_NAME: Gene and Drug Delivery Systems Study Section[GDD]


NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: SAINT LOUIS

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Cas9-based prime editing advances in vivo genome engineering by enabling precise and versatile genome editing. By performing the proposed experiments, we will optimize a modified method of prime editing in zebrafish. We will also expand the range of prime editing to facilitate generation of accurate zebrafish and other animal models to improve diagnosis, mechanistic studies and screens for therapeutics.

PI_NAMEs: SOLNICAKREZEL, LILIANNA  (contact)

PROGRAM_OFFICER_NAME: CONTRERAS, MIGUEL A

PROJECT_TERMS: Animal Model;Animals;base;Base Pairing;Binding Sites;Biological Models;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Congenital Abnormality;cost;Data;Development;Diagnosis;Disease;disease mechanisms study;disease model;DNA;DNA biosynthesis;Dose;Embryo;Endonuclease I;Enzymes;experimental study;Funding;Generations;Genes;genetic analysis;Genetic Diseases;Genetic Transcription;genetic variant;Genome;genome editing;Genome engineering;genomic locus;Goals;Guanine;Guide RNA;Human;Human Genetics;human model;improved;In Vitro;in vivo;Injections;innovation;interest;Knock-in;Laboratories;Laboratory Animals;Mammalian Cell;Methods;Missense Mutation;model organism;Modeling;mutant;Mutation;next generation sequencing;novel;novel strategies;Nucleotides;Patients;precise genome editing;prime editing;prime editor;Proteins;Rare Diseases;Relaxation;Research;Research Personnel;RNA;RNA-Directed DNA Polymerase;Site;Streptococcus;success;System;Techniques;Technology;Testing;Therapeutic;Time;Transgenic Organisms;United States National Institutes of Health;Variant;Vertebral column;Work;Zebrafish;zygote

PROJECT_TITLE: Increasing the efficiency and range of prime editing for disease modeling in zebrafish

STUDY_SECTION: TAG

STUDY_SECTION_NAME: Therapeutic Approaches to Genetic Diseases Study Section[TAG]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Neurodegenerative;Neurosciences;Parkinson's Disease

ORG_CITY: BALTIMORE

ORG_DEPT: NEUROLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Parkinson’s disease can cause cognitive impairment, like issues with memory or problem-solving, that is disabling despite adequate treatment of movement symptoms like tremor and slowness. This research project aims to study a potential mechanism of cognitive impairment by imaging the binding of a specific receptor in the brain with a PET scan and studying the role of this receptor in abnormal brain waves or “oscillations” that are found in Parkinson’s disease. Successful completion of this study would help researchers develop new treatments for cognitive impairment in Parkinson’s disease, the second most common cause of dementia in the United States.

PI_NAMEs: MILLS, KELLY ALEXANDER (contact)

PROGRAM_OFFICER_NAME: BABCOCK, DEBRA J

PROJECT_TERMS: Affect;Affinity;Age;Animals;Anterior;Area;Attention;Basal Ganglia;Binding;Biological Markers;Brain;brain abnormalities;Brain region;Characteristics;Chemistry;cholinergic;Cholinergic Receptors;cingulate cortex;Cognition;cognitive control;Cognitive deficits;cognitive function;cognitive impairment in Parkinson's;cognitive testing;Coupling;Data;Deep Brain Stimulation;Dementia;Denervation;Development;disability;Disabling;Disease;Dopamine;Electrodes;Electrophysiology (science);Etiology;executive function;Frequencies;Functional disorder;Future;Generations;Healthcare;Hippocampus;Image;Impaired cognition;improved;inattention;insight;Intervention;intervention effect;Left;Ligands;Link;Maps;Measures;Mediating;Memory;Mentored Patient-Oriented Research Career Development Award;molecular imaging;motor symptom;Movement;network dysfunction;Neurobiology;neurophysiology;neuroregulation;Neurotransmitters;Nicotinic Receptors;Noise;Operative Surgical Procedures;Parietal;Parietal Lobe;Parkinson Disease;Parkinsonian Disorders;Pathologic;Patients;Pattern;Perception;Persons;pharmacologic;Pharmacotherapy;Phase;Positron-Emission Tomography;Prefrontal Cortex;Principal Investigator;Problem Solving;Quality of life;radioligand;radiotracer;receptor;Research Personnel;Research Project Grants;Rest;Role;Severities;Short-Term Memory;Signal Transduction;Structure;Structure of subthalamic nucleus;Symptoms;System;temporal measurement;Tremor;trend;United States;Visuospatial

PROJECT_TITLE: The role of cortical nicotinic receptors in pathological brain oscillations in Parkinson's disease cognitive impairment

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Emerging Infectious Diseases;Health Services;Infectious Diseases;Lung;Networking and Information Technology R&D (NITRD);Rare Diseases;Telehealth;Tuberculosis

PHR: PROJECT NARRATIVE Contact tracing is a proven intervention for finding undiagnosed cases of tuberculosis (TB) in households of newly diagnosed TB patients, and the proposed study in Cali, Colombia, will evaluate two exciting new strategies to enhance contact tracing. We will first test if TB molecular testing on oral samples is feasible, acceptable, appropriate, and accurate for TB diagnosis in adults and children. We will then determine the feasibility, acceptability, usability, and appropriateness of mobile phone chat apps, including video calls and automated assistants, to arrange and conduct TB contact tracing procedures.

PI_NAMEs: DAVIS, JOHN LUCIAN (contact)

PROGRAM_OFFICER_NAME: LACOURCIERE, KAREN A

PROJECT_TERMS: Adult;Affect;Age;Algorithms;analytical method;arm;behavior change wheel;Caring;case finding;Cellular Phone;Cessation of life;chatbot;Child;Client;Clinic;clinical care;clinical diagnostics;Collection;Colombia;Communicable Diseases;Communities;Contact Tracing;Coughing;Country;COVID-19 pandemic;Cross-Sectional Studies;Data Collection;design;Diagnostic;diagnostic accuracy;Diagnostic tests;digital health;Education;Educational Materials;Ensure;Environment;Epidemic;Evaluation;evidence base;Evidence based practice;Evolution;expectation;Focus Groups;Friends;Future;Goals;Health system;Home;Household;implementation evaluation;implementation science;implementation strategy;implementation trial;improved;Incidence;Individual;informant;innovation;Instruction;International;Intervention;Interview;Knowledge;Liquid substance;Maps;member;Methodology;Methods;mHealth;Microscopy;Modification;Molecular;Molecular Diagnosis;Motivation;Mycobacterium tuberculosis;Newly Diagnosed;next generation;novel;Oral;Outcome;Pan American Health Organization;Patients;Performance;Persons;poor communities;prevent;Prevention;Privatization;Procedures;Public Health;Pulmonary Tuberculosis;Qualitative Methods;Qualitative Research;Randomized;Recommendation;recruit;Research;Research Design;Research Methodology;Resources;retention rate;Saliva;sample collection;Sampling;screening;secondary outcome;Services;sex;Specificity;Specimen;Sputum;support tools;Surveys;Swab;Symptoms;Techniques;telehealth;Testing;theories;Time;tool;trial enrollment;Tuberculosis;Tuberculosis diagnosis;tuberculosis diagnostics;United States Public Health Service;uptake;usability;user centered design;video chat;Visit;vulnerable community;Work

PROJECT_TITLE: Mobile Health and Oral Testing to Optimize Tuberculosis Contact Tracing in Colombia

STUDY_SECTION: SIHH

STUDY_SECTION_NAME: Science of Implementation in Health and Healthcare Study Section[SIHH]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Immunization;Immunotherapy;Infectious Diseases;Lung;Nanotechnology;Pediatric;Prevention;Vaccine Related;Women's Health Research

ORG_CITY: PITTSBURGH

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: This proposal aims to optimize and characterize a novel vaccine formulation designed to safely improve the immune response to respiratory syncytial virus (RSV), a disease that causes significant morbidity and mortality in young children and for which no preventable vaccine exists. This novel nanoparticle vaccine formulation uses a biodegradable platform with inherent adjuvant properties to deliver a potent RSV antigen that is more readily taken up by dendritic cells, which are responsible for inducing antibody production and antiviral T cell responses. The tunable nature of the system allows one to tailor the antigen dose and adjuvant potency to balance efficacy and safety profiles, and in this proposal, will be optimized in an established mouse model of RSV infection.

PI_NAMEs: EMPEY, KERRY MCGARR (contact);MENG, WILSON S

PROGRAM_OFFICER_NAME: KIM, SONNIE

PROJECT_TERMS: 5 year old;Acute;Adjuvant;Adult;aluminum sulfate;Alveolar Macrophages;Antibodies;Antibody Formation;Antibody-mediated protection;Antigen-Presenting Cells;Antigens;Avidin;Biotin;Biotinylation;Breast Feeding;burden of illness;CD8-Positive T-Lymphocytes;CD8B1 gene;Child;Childhood;Chimeric Proteins;clinical development;Clinical Trials;clinically relevant;Collaborations;Communities;Coupling;cytokine;Data;Dendritic Cells;design;Disease;Dose;Drug Delivery Systems;Dyes;Ensure;Environment;Equilibrium;Exhibits;Family;Flow Cytometry;Formulation;Frequencies;Generations;Glycolates;Half-Life;Hospital Charges;Hospitalization;immune activation;immune activator;Immune response;Immunity;Immunization;Immunize;immunogenicity;Immunoglobulin A;Immunoglobulin G;improved;in vivo;Inbred BALB C Mice;Infant;Infection;Inflammation;Injections;innovation;insight;Interferon Type II;Interleukin-12;Intramuscular;Intranasal Administration;Kinetics;Label;Lead;Letters;Licensing;Life;Lipids;Lower Respiratory Tract Infection;Lung;manufacture;Maternal antibody;maternal outcome;Methods;Molecular;Molecular Conformation;Morbidity - disease rate;mortality;Mothers;mouse model;Mucous body substance;Mucous Membrane;Mus;nanoparticle;nanovaccine;Nature;neutralizing antibody;novel;novel vaccines;particle;pathogen;Pharmacy (field);Phase;Population;pre-clinical;Predisposition;preservation;Prevention;Production;Property;Protein Conformation;Protein Engineering;Proteins;prototype;Quality of life;Research Personnel;Respiratory Disease;Respiratory syncytial virus;Respiratory Syncytial Virus Infections;Respiratory Syncytial Virus Vaccines;response;Risk Reduction;Safety;Severities;Site;Solvents;Structure;Surface;System;T cell response;Teenagers;Testing;Time;tissue resident memory T cell;uptake;Vaccination;vaccine candidate;vaccine delivery;vaccine development;vaccine formulation;vaccine platform;Vaccines;Variant;Viral;Viral Antigens;Wheezing

PROJECT_TITLE: Optimization of a Self-Adjuvanting Particle System for Delivering Respiratory Syncytial Virus Prefusion Protein

STUDY_SECTION: VMD

STUDY_SECTION_NAME: Vaccines Against Microbial Diseases Study Section[VMD]


NIH_SPENDING_CATS: Genetics;Infectious Diseases

ORG_CITY: STORRS-MANSFIELD

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF CONNECTICUT STORRS

PHR: MODIFIED PUBLIC HEALTH RELEVANCE Inflammation can result in the irreversible buildup of fibrosis, an extracellular matrix of collagen and fibrinogen that contributes to a wide variety of chronic and lethal diseases in humans. The proposed research will help identify genes and immune pathways that contribute to natural genetic variation in the risk of fibrosis onset, the severity of fibrosis, and vertebrates’ ability to recover from fibrosis. Concurrently, we seek to identify strategies that parasitic tapeworms use to interfere with animals’ fibrosis, which may present opportunities for therapeutic interventions to treat, or promote recovery from, peritoneal fibrosis.

PI_NAMEs: BOLNICK, DANIEL IMARA (contact)

PROGRAM_OFFICER_NAME: JOY, DEIRDRE A

PROJECT_TERMS: Adjuvant;Affect;aluminum sulfate;Animals;arms race;Attenuated;attenuation;Biological Models;body cavity;Breeding;Cestoda;Cestode Infections;Chromosome Mapping;Chronic;chronic infection;Cicatrix;Clustered Regularly Interspaced Short Palindromic Repeats;Cohort Studies;Collagen;cost;CRISPR/Cas technology;Disease;Encapsulated;Evolution;Exhibits;Experimental Models;Extracellular Matrix;Fertility;Fibrinogen;Fibrosis;Fishes;Fresh Water;Gasterosteidae;Genes;Genetic;genetic analysis;Genetic Epistasis;Genetic Screening;Genetic Variation;genome wide association study;Genomics;Genotype;Geography;Goals;Growth;helminth infection;Helminths;Heritability;Host resistance;Human;Hybrids;Immune;Immune Evasion;Immune response;Immune system;Immunity;Immunogenetics;Immunologics;Infection;Inflammation;Inflammatory Response;Injections;Intraperitoneal Injections;Lesion;Maps;Mobility decline;model organism;Modeling;Morbidity - disease rate;mortality;Nematoda;Outcome;parasite genome;Parasites;Pathologic;Pathology;Pathway interactions;Peritoneal;Peritoneum;Phenotype;Population;Proteins;Proteomics;public health relevance;Quantitative Trait Loci;Recording of previous events;Recovery;Reproduction;Research;Resistance;response;Risk;Sclerosis;Severities;Speed;success;synergism;System;systems research;Testing;theories;Therapeutic;Therapeutic Intervention;Tissues;tool;trait;transcriptomics;Variant;Vertebrates;Work

PROJECT_TITLE: Reciprocal genetics of recently-evolved vertebrate immunity and helminth counter-adaptation

STUDY_SECTION: GVE

STUDY_SECTION_NAME: Genetic Variation and Evolution Study Section[GVE]


NIH_SPENDING_CATS: Charcot-Marie-Tooth Disease;Genetics;Neurodegenerative;Neurosciences;Peripheral Neuropathy;Rare Diseases

ORG_CITY: Nashville

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: Narrative Charcot-Marie-Tooth Disease (CMTD) is a peripheral neuropathy that afflicts roughly 1 out of every 2500 people and for which there is no cure or therapeutic drug. The most common forms of CMTD are caused by genetic defects affecting intracellular trafficking of the protein peripheral myelin protein 22 (PMP22). The goals of this project are to determine by exactly what pathways the PMP22 traffics in the cell under both healthy and pathological conditions, as well as to examine how interactions with other proteins impact PMP22 trafficking.

PI_NAMEs: CARTER, BRUCE D;SANDERS, CHARLES R (contact)

PROGRAM_OFFICER_NAME: NUCKOLLS, GLEN H

PROJECT_TERMS: 26S proteasome;3-Dimensional;Address;Affect;Alleles;Amino Acid Sequence;Autophagocytosis;base;biological adaptation to stress;Cell surface;Cells;Cellular biology;Charcot-Marie-Tooth Disease;Coculture Techniques;Complex;crosslink;Cytosol;Data;Defect;Destinations;Disease;disorder subtype;EIF-2alpha;Fluorescence Microscopy;gain of function;Goals;Golgi Apparatus;hereditary neuropathy;Heterozygote;Human;Impairment;Inherited;knock-down;Knowledge;loss of function;Missense Mutation;Modeling;Molecular;multicatalytic endopeptidase complex;Mus;mutant;Mutation;Myelin;Myelin Proteins;myelination;Nature;Nerve;Neurons;overexpression;Paralysed;Pathogenicity;Pathologic;Pathology;Pathway interactions;Peripheral;Peripheral Nervous System Diseases;Persons;Pharmaceutical Preparations;Phosphorylation;Phosphotransferases;PMP22 gene;pressure;protein transport;Proteins;Rattus;Role;Schwann Cells;Site;Syndrome;Testing;Therapeutic;trafficking;Translations;Trisomy;unnatural amino acids;Up-Regulation;Variant;Wild Type Mouse;Work

PROJECT_TITLE: Folding, Misfolding, and Function of PMP22

STUDY_SECTION: BBM

STUDY_SECTION_NAME: Biochemistry and Biophysics of Membranes Study Section[BBM]


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Mental Health;Neurosciences;Pediatric;Tourette Syndrome

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

PHR: PROJECT NARRATIVE Tourette syndrome (TS) is a prevalent neurodevelopmental disorder clinically defined by the presence of tics, but the majority of adults and children with TS also experience sensory over-responsivity, defined as heightened awareness of and behavioral reactivity to commonplace environmental stimuli. The overarching goals of this research proposal are to clarify the neurophysiologic mechanisms underlying sensory over- responsivity and to determine whether sensory over-responsivity is a risk marker for more severe clinical course in TS.

PI_NAMEs: ISAACS, DAVID A (contact)

PROGRAM_OFFICER_NAME: SIEBER, BETH-ANNE

PROJECT_TERMS: Academic Medical Centers;Accounting;Adolescence;Adolescent;Adult;Affect;Age;age group;Aptitude;arm;Attention deficit hyperactivity disorder;Auditory;Autonomic Dysfunction;Award;Awareness;base;Behavior;Behavioral;Biological Markers;candidate identification;candidate marker;career;career development;Child;Childhood;Clinic;Clinical;Clinical and Translational Science Awards;clinical development;clinical infrastructure;Clinical Management;Clinical Research;clinical risk;Clinical Trials;Clinical Trials Design;clinically significant;Clothing;Data;Development;Development Plans;Diagnosis;Dimensions;Disease;disease model;Distress;Educational Curriculum;Educational workshop;Electroencephalography;Emotional;Ensure;Environment;Event;Event-Related Potentials;Exhibits;experience;Faculty;follow-up;Fostering;Frequencies;Functional disorder;Functional impairment;Funding;Future;General Population;Gilles de la Tourette syndrome;Goals;Grant;Heart Rate;heart rate variability;Heterogeneity;Impairment;improved;indexing;Individual;Industry;insight;Institution;International;Investigation;Knowledge;life span;Link;Longitudinal Studies;Measurement;Mental disorders;Mentors;Methodology;Mission;Modeling;Monitor;Motor;motor symptom;Movement Disorders;multimodality;National Institute of Neurological Disorders and Stroke;Nature;Neurobiology;Neurodevelopmental Disorder;Neurology;neurophysiology;neuropsychiatric symptom;Noise;non-motor symptom;novel;Older Population;patient oriented;Patients;Perception;Pharmaceutical Preparations;Phenotype;Physiological Processes;Population;Practice Guidelines;premonitory sensory phenomena;Principal Investigator;Productivity;professor;psychiatric symptom;Psychophysiology;Quality of life;recruit;Reporting;Research;Research Personnel;Research Project Grants;Research Proposals;Research Support;response;Rest;Risk;Risk Marker;Sample Size;Sampling;Scalp structure;School-Age Population;Scientist;Secure;Sensory;Sensory Disorders;sensory gating;sensory input;Sensory Manifestations;sensory stimulus;Severities;sex;Signal Transduction;Site;Skin;Stimulus;study population;symposium;Symptoms;Tactile;Techniques;Time;Training;Visit

PROJECT_TITLE: Neurophysiologic Correlates of Sensory Over-Responsivity in Tourette Syndrome

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-1 Study Section[NST-1]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Genetics;Neurosciences

ORG_DEPT: PATHOLOGY

PHR: PROJECT NARRATIVE Neural circuits in the brain undergo activity-dependent changes in structure and function, called neural plasticity, which is largely restricted to early developmental windows called critical periods. Inappropriate critical period extension is linked to neurological disorders such as autism and epilepsy, yet the mechanisms terminating critical periods are poorly understood. The experiments outlined in this proposal will define the cellular and molecular mechanisms that trigger critical period closure, as well as the physiological contribution of critical periods to mature circuit function and behavior.

PI_NAMEs: ACKERMAN, SARAH D (contact)

PROGRAM_OFFICER_NAME: JOHNSON, KARI ANNE

PROJECT_TERMS: Ablation;Address;Adult;Affect;Animal Model;Architecture;Astrocytes;autism spectrum disorder;Award;Axon;Behavior;behavior change;Binding;Biological Assay;Biological Models;Brain;career development;cell type;Communities;CRISPR/Cas technology;critical period;Cytoskeleton;Data;defined contribution;Dendrites;Development;Drosophila genus;Electrophysiology (science);Ensure;Environment;Epilepsy;experience;experimental study;Failure;Fishes;fly;Funding;Future;Genes;Genetic;genetic approach;Goals;Hour;Human;Image;Individual;Laboratories;Learning;Life;Link;Locomotion;medical schools;Memory;Mentors;Mentorship;Microtubule Polymerization;Microtubules;Modeling;Molecular;Molecular Genetics;Morphology;Motor;motor behavior;Motor Neurons;Motor output;Muscle;Mutation;myelination;Nervous System Disorder;neural circuit;Neurodevelopmental Disorder;Neuronal Plasticity;Neurons;Neurosciences;neurotransmission;novel;optogenetics;Oregon;Output;Pathway interactions;Pharmacology;Phase;Physiological;Physiology;Predisposition;Principal Investigator;programs;Research;reverse genetics;Role;Seasons;Series;Shapes;Signal Transduction;single-cell RNA sequencing;skills;Stereotyped Behavior;Structure;Synapses;Synaptic plasticity;synaptogenesis;System;Techniques;Testing;Time;Training;transcriptome sequencing;Universities;Vertebrates;Work;Zebrafish

PROJECT_TITLE: The role of astrocyte-neuron signaling in closing a critical period required for motor circuit structure function and behavior


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Mental Illness;Pediatric;Post-Traumatic Stress Disorder (PTSD);Prevention;Women's Health Research

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE Maternal mental health critically influences the wellness of the mother and the developing child. Some individuals experience traumatic childbirth and subsequently develop posttraumatic stress disorder, which can undermine maternal health and the health of the child from the time of birth and onward, resulting in heavy health costs. Currently, there is no preventive intervention to reduce the occurrence of this illness; and this study could lay the foundation for preventive and holistic care for mothers to foster maternal resilience and optimize child welfare.

PI_NAMEs: DEKEL, SHARON  (contact)

PROGRAM_OFFICER_NAME: GIRARDI, GUILLERMINA

PROJECT_TERMS: acute stress;adverse maternal outcomes;Affect;American;American College of Obstetricians and Gynecologists;Beginning of Life;behavior observation;Biological;biological adaptation to stress;Birth;Buffers;Caring;Child;Child Development;Child Health;child physical abuse;Child Welfare;Childbirth;Clinical;Clinical Trials;cost;cost effective;cost effective treatment;depressive symptoms;Diagnosis;diagnostic tool;Disease;Early Intervention;Early treatment;effective intervention;Emotional;emotional distress;Enhancers;Event;experience;expressive writing;Fostering;Foundations;Functional disorder;Funding;Future;Growth;Health Care Costs;High Risk Woman;Hospitals;Hour;Imagery;Impairment;improved;Individual;Infant;infant outcome;intergenerational;Intervention;Maternal Health;maternal morbidity;Maternal Mortality;Measures;Mediating;Medical Care Costs;Mental disorders;Mental Health;Methodology;Mission;Morbidity - disease rate;Mother-Child Relations;Mothers;National Institute of Child Health and Human Development;Outcome;physical neglect;Physiological;Post-Traumatic Stress Disorders;post-traumatic symptoms;Postpartum Depression;Postpartum Period;Postpartum Women;Pregnancy;Preventive;preventive intervention;Preventive treatment;Productivity;psychologic;Psychometrics;Psychopathology;Psychophysiology;Public Health;Quality of Care;Randomized;Randomized, Controlled Trials;Recommendation;Recovery;remote delivery;Reporting;Reproductive Process;resilience;response;Risk;Special needs;Survivors;Symptoms;Testing;Therapeutic;Time;tool;Trauma;traumatic event;treatment effect;United States National Institutes of Health;Visit;Woman;Work;Writing

PROJECT_TITLE: The effects of expressive writing following traumatic childbirth

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Clinical Research;Nutrition;Obesity;Women's Health Research

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

ORG_STATE: NY

PHR: PROJECT NARRATIVE Epidemiologic studies have linked obesity to poor breast cancer outcomes, and it has been suggested that obese women may experience poorer outcomes, in part, due to dose reductions of chemotherapy drugs; this is because most cytotoxic agents are dosed according to body size, and clinicians may scale back the high doses administered to obese women due to concern about inducing toxicity. Given persisting uncertainty about dosing obese women, in a study population of nearly 34,000 women with breast cancer who were diagnosed and treated in two integrated healthcare delivery systems, Kaiser Permanente Northern California and Group Health, we propose to: i) examine the relationship between body size and dose intensity, and will further examine how the factors contributing to dose reductions vary by body size, ii) evaluate whether chemotherapy dose reductions mediate the associations between obesity and adverse breast cancer outcomes, and iii) evaluate the association between body size and toxicity among women identified as receiving the full body-size determined dose of chemotherapy. Addressing these questions will provide the evidence needed to better inform clinicians treating the 102,000 obese women diagnosed with breast cancer each year in the United States.

PI_NAMEs: KANTOR, ELIZABETH DAVID (contact)

PROGRAM_OFFICER_NAME: SHELBURNE, NONNIEKAYE F

PROJECT_TERMS: Address;Adult women;adverse outcome;Age;American Society of Clinical Oncology;Automobile Driving;Back;Body mass index;Body Size;Body Surface Area;Breast;Breast Cancer Patient;breast cancer survival;California;Cancer Patient;cancer recurrence;cancer survival;Cardiotoxicity;Cardiovascular Diseases;Characteristics;chemotherapy;Clinical Management;clinically relevant;comorbidity;Cytotoxic agent;Data;data integration;Data Sources;Diabetes Mellitus;Diagnosis;Disease;Dose;Epidemiology;epidemiology study;Ethnic Origin;experience;follow-up;Fright;Gender;Guidelines;Health;Hepatic;Hormone Receptor;Impairment;improved;Integrated Delivery of Health Care;Intervention;Investigation;Kidney;Kidney Diseases;Knowledge;Link;Malignant Breast Neoplasm;Mediating;Mediator;Medical Oncology;Meta-Analysis;Modification;Morbid Obesity;mortality;Neuropathy;Neutropenia;Nodal;Non obese;novel;obese patients;Obesity;optimal treatments;Outcome;Patients;Pharmaceutical Preparations;Pharmacology;Positioning Attribute;Prevalence;Prognosis;Provider;provider factors;Race;Recommendation;Recurrence;Reporting;Research;Risk;Role;study population;System;Toxic effect;Treatment-related toxicity;Uncertainty;United States;Weight;Woman;women's diagnosis

PROJECT_TITLE: Obesity, chemotherapy dosing, and breast cancer outcomes

STUDY_SECTION: CHSA

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology A Study Section[CHSA]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Comparative Effectiveness Research;Cost Effectiveness Research;Drug Abuse (NIDA only);Harm Reduction for Substance Misuse;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: RESEARCH TRIANGLE PARK

ORG_NAME: RESEARCH TRIANGLE INSTITUTE

ORG_STATE: NC

PHR: PROJECT NARRATIVE This study will examine the effects and cost of opioid interventions at the state and local level to assist policy makers and health professionals in North Carolina. Using publicly available data and published literature we will build a geographically explicit agent-based model (ABM) that will simulate individual trajectories to opioid overdose and death under different intervention scenarios. These interventions will reflect North Carolina Opioid Action Plan 2 and focus on “three pillars” prevention, connection to care, and reduction of harm. We will use representative synthetic populations to link individual trajectories with local environment and context.

PI_NAMEs: BOBASHEV, GEORGIY  (contact)

PROGRAM_OFFICER_NAME: DEPADILLA, LARA MIREILLE

PROJECT_TERMS: Accounting;Address;Affect;Awareness;Buprenorphine;Calibration;Caring;Centers for Disease Control and Prevention (U.S.);Cessation of life;Characteristics;Communities;Complex;cost;cost effective;cost effective intervention;cost effectiveness;cost estimate;County;dashboard;Data;Databases;Death Rate;drug market;Effectiveness of Interventions;Emergency department visit;Environment;Environmental Risk Factor;Epidemic;Epidemiology;Evidence based intervention;Fentanyl;geographic difference;Geography;Goals;Guidelines;Harm Reduction;Health Professional;Heroin;Improve Access;Individual;Injections;Intervention;Legal;Life;Link;Literature;Measures;medication-assisted treatment;Methadone;Methodology;Modality;Modeling;models and simulation;Morbidity - disease rate;mortality;multiple data sources;multiple data types;naloxone dispensing;Naltrexone;North Carolina;online community;Opioid;opioid misuse;opioid mortality;opioid overdose;opioid policy;opioid use;Outcome;Overdose;overdose death;Pathway interactions;Patients;Peer Review;Persons;Pharmaceutical Preparations;Pharmacotherapy;Physicians;Policies;Policy Maker;Population;Population Density;Poverty;predicting response;prescription opioid;Prevention;Privacy;Probability;Public Health;Publishing;Recommendation;Recovery;Resources;Review Literature;social interventions;social stigma;Source;Specific qualifier value;Stimulant;Structure;Surveys;System;Time;Uncertainty;United States Dept. of Health and Human Services;Variant;Work

PROJECT_TITLE: Opioid Policy Model

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-W(55)R]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics

ORG_CITY: CLEVELAND

ORG_DEPT: GENETICS

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: Cell fate choice and commitment is critical for normal development. Loss of cell fate can lead to developmental disorders, cancer, and infertility. By providing fundamental insights into how cell fates are acquired and maintained, our work may suggest new approaches for diagnosing and treating human diseases.

PI_NAMEs: SALZ, HELEN KAREN (contact)

PROGRAM_OFFICER_NAME: SALAZAR, DESIREE LYNN

PROJECT_TERMS: Acceleration;Brain;Cells;Chromatin;Code;Development;developmental disease;Diagnosis;Disease;DNA Transposable Elements;Drosophila genus;Epigenetic Process;Female;Fission Yeast;fly;Gene Silencing;Genes;genetic approach;Germ Cells;Germ Lines;Goals;Heterochromatin;histone modification;Human;human disease;Infertility;insight;Knowledge;Logic;male;Malignant Neoplasms;Mediating;Modernization;Molecular;novel strategies;Organism;Proteins;Publishing;recruit;Regulator Genes;Repression;Research;Role;Secure;Somatic Cell;Technology;Testis;Tissues;Work

PROJECT_TITLE: H3K9me3-based gene silencing and cellular identity

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: STANFORD

ORG_DEPT: NEUROSURGERY

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: Project Narrative The goal of the proposed work is to understand how the diverse cell types in the human retina process visual information and transmit it to the brain, and how this compares to the large existing body of work from the closest animal model. Using a collection of novel techniques, we are now able to study the functioning of retinas obtained from human donors. This work will make it possible to understand the function of the human retina in ways that were never before possible, with implications ranging from understanding human vision to diagnosing visual disorders and developing retinal implants to treat incurable blindness.

PI_NAMEs: CHICHILNISKY, EDUARDO  (contact)

PROGRAM_OFFICER_NAME: WRIGHT, CHARLES BAKER

PROJECT_TERMS: Amacrine Cells;analytical method;Anatomy;Animal Model;Area;Behavioral;Blindness;Brain;Cell Communication;cell type;Collection;Data;Data Set;Databases;density;Diagnosis;electrical property;Evolution;Exhibits;experience;experimental study;ganglion cell;Glean;Goals;Homologous Gene;Human;human data;human tissue;improved;Kinetics;Knowledge;large datasets;Learning;Light;Macaca;machine learning method;Manuals;Methods;Mining;Modeling;Monkeys;Morphology;mosaic;multi-electrode arrays;Neural Network Simulation;novel;Output;preservation;Primates;Property;receptive field;Reporting;Research;response;Retina;retina implantation;Retinal Ganglion Cells;Role;Shapes;sight restoration;Signal Transduction;species difference;Stereotyping;Structure;Techniques;Testing;Textbooks;transmission process;Vision;Vision Disorders;Visual;visual information;Visual Pathways;visual processing;Work

PROJECT_TITLE: Diverse visual processing properties of novel ganglion cell and amacrine cell types in the human retina

STUDY_SECTION: NBVP

STUDY_SECTION_NAME: Neuroscience of Basic Visual Processes Study Section[NBVP]


ORG_CITY: LONDON

ORG_COUNTRY: UNITED KINGDOM

ORG_FIPS: UK

ORG_NAME: KING'S COLLEGE LONDON

ORG_ZIPCODE: WC2R 2LS

PHR: Narrative Although ovarian aging is a natural physiological process, cessation of ovarian function at midlife increases susceptibility to the development of co-morbidities, with no intervention to prevent/delay this, highlighting a current unmet need in women’s health. Follicle stimulating hormone is essential for reproduction and undergoes aging-dependent changes in its glycosylation pattern, which alters its bioactivity. This study will determine how FSH glycosylation regulates FSH receptor oligomerisation and trafficking, and downstream consequences in young and aging ovaries, using a novel N-terminally FLAG-tagged FSHR mouse model, coupled with high resolution imaging and integrated transcriptomics and genomics analysis, which will provide key insights to improve ovarian function, with translational potential to improve/extend reproductive longevity and overall health and wellbeing.

PI_NAMEs: DAVIS, JOHN S;JONAS, KIM CAROL (contact)

PROGRAM_OFFICER_NAME: TAYMANS, SUSAN

PROJECT_TERMS: Adaptor Signaling Protein;Age;age related;age related changes;aged;Aging;Assisted Reproductive Technology;ATAC-seq;Binding;Binding Proteins;Biological Assay;Biological Markers;Cell Line;Cell membrane;Cell surface;Color;comorbidity;Complex;Coupled;Cyclic AMP;Data;Development;dimer;Dissociation;encryption;Endosomes;Event;Fertility;Follicle Stimulating Hormone;Follicle Stimulating Hormone Receptor;folliculogenesis;G-Protein-Coupled Receptors;Generations;Genome;Genomics;Glycoproteins;glycosylation;granulosa cell;Health;Health Care Costs;healthcare burden;high resolution imaging;Hormonal;Hormones;Human;Immunofluorescence Immunologic;improved;innovation;insight;Intervention;Kinetics;Knock-in Mouse;Knowledge;life span;Lighting;Link;Mediating;Mediator;Menopause;middle age;monomer;mouse model;multiple omics;Mus;N-terminal;Nature;novel;novel strategies;Osteoporosis;Outcome;Output;Ovarian;Ovarian aging;Ovarian Follicle;Ovary;Pattern;Peptides;Perimenopause;Personal Satisfaction;Physiological Processes;Pituitary Gland;Population;Predisposition;prevent;Process;Production;Property;Protomer;Publishing;Quality of life;receptor;receptor function;receptor internalization;Receptor Signaling;Regulation;Reporting;Reproduction;reproductive;reproductive hormone;reproductive longevity;reproductive senescence;Resistance;Role;Route;Second Messenger Systems;sensor;Serum;Signal Pathway;Signal Transduction;Structure;superresolution imaging;Testing;Therapeutic;Total Internal Reflection Fluorescent;trafficking;Transcriptional Regulation;transcriptome;transcriptome sequencing;transcriptomics;translational potential;Woman;Women's Health;Work

PROJECT_TITLE: Understanding The Role Of FSHR Oligomerization And Trafficking In Transducing Age-dependent Changes In FSH Glycoforms

STUDY_SECTION: ICER

STUDY_SECTION_NAME: Integrative and Clinical Endocrinology and Reproduction Study Section[ICER]


NIH_SPENDING_CATS: Biotechnology;Eye Disease and Disorders of Vision;Gene Therapy;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: DURHAM

ORG_DEPT: NEUROSCIENCES

ORG_NAME: DUKE UNIVERSITY

PHR: PROJECT NARRATIVE This work is relevant to public health because CRB1 disease is a prevalent cause of inherited retinal degenera- tion, which presently has no effective treatments. Insight into CRB1 disease mechanisms derived from this pro- ject is expected to yield a translation-ready gene therapy strategy, which would directly benefit CRB1 disease patients and possibly also create positive impacts for patients afflicted by other inherited degenerations with similar underlying pathologic mechanisms.

PI_NAMEs: KAY, JEREMY N (contact)

PROGRAM_OFFICER_NAME: SHEN, GRACE L

PROJECT_TERMS: Adhesions;Alleles;Anatomy;Behavior;Behavioral;Biochemical;Biological Assay;Blindness;Cell Adhesion;Cell Polarity;Cell surface;cell type;Cells;Cessation of life;combinatorial;Complex;Data;Defect;Development;Disease;disease model;disease phenotype;Dysplasia;effective therapy;Electrophysiology (science);Embryo;Event;Excision;Formulation;functional improvement;functional restoration;Gene Family;gene function;gene replacement;gene replacement therapy;gene therapy;Genes;Goals;Human;Impairment;in vivo;Individual;Inherited;inherited retinal degeneration;innovation;insight;Knowledge;Laboratories;Learning;loss of function mutation;Mediating;member;Messenger RNA;Molecular;mouse model;Mouse Strains;Muller's cell;Mus;mutant;Mutant Strains Mice;Mutation;novel;Outcome;Outer Limiting Membrane;Pathologic;Pathology;Patients;Pattern;Phenotype;photoreceptor degeneration;Photoreceptors;postnatal;Preclinical Testing;prevent;Prevention;Protein Isoforms;Proteins;Public Health;Replacement Therapy;Research Personnel;Retina;Retinal Diseases;Retinal Dysplasia;retinal progenitor cell;retinal rods;Rod;Role;selective expression;Series;Severities;Site;spatiotemporal;Testing;Therapeutic;Time;Transgenic Organisms;Translations;Variant;Visual impairment;Work

PROJECT_TITLE: Molecular and cellular requirements for Crb1 gene function in the onset and therapeutic rescue of an inherited retinal degeneration

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 1 Study Section[PED1]


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Prevention;Women's Health Research

ORG_CITY: ITHACA

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: CORNELL UNIVERSITY

PHR: PROJECT NARRATIVE Identifying evolutionary mechanisms that naturally protect species from developing cancer is becoming an increasingly appreciated approach to develop therapeutic strategies that are both efficient and non-toxic. In the proposed studies, we will build further on our recent finding that mammary cells from domesticated mammals with low mammary incidence secrete bioactive factors that kill breast cancer cells in vitro and reduce tumorigenicity in vivo. The knowledge gained from these studies will increase our knowledge of novel cancer- suppressing mechanisms that will accelerate the identification of novel breast cancer therapeutic and/or preventative agents.

PI_NAMEs: HARMAN, REBECCA M (contact)

PROGRAM_OFFICER_NAME: CHRISTEN, JAYNE

PROJECT_TERMS: Acceleration;Affect;aggressive therapy;anti-cancer;anticancer activity;Apoptosis;Apoptotic;Behavior;Biological;Biological Products;Breast;Breast Cancer Cell;Breast Cancer Patient;Breast Cancer Prevention;Breast Cancer Treatment;Breast Epithelial Cells;Cancer Etiology;cancer prevention;cancer therapy;cancer type;Cattle;Cell Death;Cell Line;Cell Separation;Cell surface;Cell Survival;cell transformation;cell type;Cells;Cessation of life;Data;design;Development;DNA Damage;efficacy evaluation;Elephants;Epithelial Cells;Equus caballus;experimental study;Exploratory/Developmental Grant;extracellular vesicles;fighting;Filtration;follow-up;Follow-Up Studies;Formulation;high risk population;hormone therapy;Human;In Vitro;in vivo;in vivo Model;Incidence;Individual;inhibitor;innovation;insight;Intervention;Knowledge;Malignant Breast Neoplasm;Malignant Neoplasms;Mammals;mammary;Mammary Neoplasms;Mammospheres;MDA MB 231;Mediating;metastasis prevention;Modeling;mortality;mouse model;multiple omics;Nature;novel;novel therapeutics;Organ;patient derived xenograft model;Patients;Population;pre-clinical;prevent;preventive intervention;protective factors;rational design;refractory cancer;Regulation;Relapse;repaired;Reporting;Reproducibility;Research;Resistance;response;Role;single-cell RNA sequencing;Solid;Sphingomyelins;standard of care;stem;stem cells;Testing;Therapeutic;Therapeutic Intervention;tool;Translations;treatment response;triple-negative invasive breast carcinoma;tumor;Tumorigenicity;Ultracentrifugation;Woman;Xenograft procedure

PROJECT_TITLE: The mammary cell secretome as a novel biologic for triple-negative breast cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-A (O1)]


NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Biomedical Imaging;Clinical Research;Neurosciences;Rehabilitation

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

PHR: Narrative: Spinal cord stimulation (SCS) is becoming increasingly important in treating various neurological disfunctions. Though it is much less invasive than other direct brain stimulation techniques (e.g. deep brain stimulations) which benefit from precise imaging guidance, the current practices of SCS do not yet have the same target accuracy due to current limitations in imaging spine-brain pathways. Here we propose to develop the much-needed hardware and software solutions for high-resolution diffusion MRI to overcome these limitations and map in detail all the relevant spine-brain pathways and their associated brain connectivities, which can then be used to improve the site-planning accuracy of SCS, leading to targeted neural stimulations in patients to increase effectiveness and efficiency.

PI_NAMEs: DARNELL, DEAN ;SONG, ALLEN W (contact);TRUONG, TRONG-KHA

PROJECT_TERMS: Address;Air;Anatomy;Area;bone;Brain;Brain Diseases;Brain imaging;Brain Mapping;brain pathway;Brain region;Breathing;Chest wall structure;Communication;Communities;Compensation;Computer software;Data;Deep Brain Stimulation;design;Development;Devices;Diffusion;Diffusion Magnetic Resonance Imaging;Effectiveness;Goals;Growth;Image;image guided;imaging modality;Imaging technology;improved;in vivo;innovation;magnetic field;Magnetic Resonance Imaging;Maps;Methodology;Methods;Motion;motion sensor;Motor;motor function recovery;Movement;Movement Disorders;neural;neural stimulation;Neurologic;Neurosciences;Neurostimulation procedures of spinal cord tissue;Noise;novel;Pain management;Parkinson Disease;Patients;Physiologic Monitoring;Process;public database;reduce symptoms;Research Personnel;Resolution;RF coil;Sensory;Signal Transduction;simulation;Site;somatosensory;Speed;Spinal Cord;Spinal cord injury;spinal pathway;Standardization;Stroke;Techniques;Time;Tissues;transmission process;Vertebral column;wireless;wireless communication;wireless fidelity

PROJECT_TITLE: Integrated RF/Shim/WiFi Coil Array for High-Resolution Diffusion MRI in the Brain and Spinal Cord

STUDY_SECTION: ITD

STUDY_SECTION_NAME: Imaging Technology Development Study Section[ITD]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Cardiovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Heart Disease;Nutrition;Prevention;Social Determinants of Health

ORG_CITY: PHILADELPHIA

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE Low-income individuals experiencing food insecurity – the economic and social condition of inconsistent access to healthy food – have a disproportionately higher burden of cardiovascular disease. This study aims to understand whether participation in the Supplemental Nutrition Assistance Program (SNAP) – the largest government funded food assistance program in the US – is linked with improvements in cardiovascular health for low-income individuals. The findings of this study will also identify which SNAP-related policies can potentially impact cardiovascular health outcomes, which is particularly relevant in light of the many changes the program has undergone during the COVID-19 pandemic.

PI_NAMEs: KHATANA, SAMEED AHMED MUSTAFA (contact)

PROGRAM_OFFICER_NAME: BROWN, ALISON GWENDOLYN MARY

PROJECT_TERMS: Acute;Address;Adult;American;Cardiovascular Diseases;cardiovascular health;cardiovascular risk factor;Cardiovascular system;Caring;Categories;Congestive Heart Failure;Coronary Arteriosclerosis;cost;COVID-19 pandemic;Data;Databases;Diabetes Mellitus;Diagnostic;Disease;Economic Conditions;Eligibility Determination;Emergency department visit;Event;experience;Food;Food Assistance Programs;food insecurity;food security;Funding;geographic disparity;Government;Growth;Health;Health and Retirement Study;health assessment;Health Benefit;health care service utilization;Health Expenditures;Health Food;Heart failure;High Prevalence;Hyperlipidemia;Hypertension;implementation evaluation;improved;Incidence;indexing;Individual;insight;Interruption;Investments;Lead;Light;Link;Low income;Low Income Population;Measures;Mediating;Medicaid;Medicare;Medicare/Medicaid;medication compliance;Myocardial Infarction;nutrition;Office Visits;older adult;Outcome;Outpatients;outreach;Participant;Policies;Policy Maker;Poverty;poverty alleviation;poverty reduction;Prevalence;programs;Psychosocial Stress;Public Health;Publishing;Recovery;Research;Risk Factors;Schedule;Self Assessment;Series;Social Conditions;Social Policies;social stigma;Source;Stroke;Surveys;Techniques;Time;Variant

PROJECT_TITLE: The impact of the Supplemental Nutrition Assistance Program on the cardiovascular health of low-income adults

STUDY_SECTION: SSPA

STUDY_SECTION_NAME: Social Sciences and Population Studies A Study Section[SSPA]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Immunotherapy;Patient Safety

ORG_CITY: BOSTON

ORG_NAME: DANA-FARBER CANCER INST

PHR: Patients require robust, reliable, and clinically interpretable quantitative information about the risk and benefit of a new therapy when making treatment decisions; however, the standard statistical approach using Cox’s hazard ratio falls short of this important goal. The proposed study will fill this gap in practice by developing and disseminating a novel statistical method, the general Censoring-Free person-time Incidence Rate (gCFIR), to improve interpretation of the treatment effect magnitude and increase the likelihood that results from clinical research are correctly interpreted by clinicians and translated to patient care.

PI_NAMEs: UNO, HAJIME  (contact)

PROGRAM_OFFICER_NAME: WANG, PEGGY

PROJECT_TERMS: American Society of Clinical Oncology;analytical method;Attention;Base Ratios;Benefits and Risks;cancer immunotherapy;cancer therapy;Clinical;Clinical Data;clinical practice;Clinical Research;clinical trial analysis;Clinical Trials;Communication;Communities;comparative effectiveness study;Computer software;Data;Data Analyses;Databases;Decision Making;Event;Feedback;Future;Goals;hazard;immunotherapy trials;improved;Incidence;Individual;Internal Medicine;Measures;Medicare;member;method development;Methodology;Methods;New Drug Approvals;novel;novel strategies;novel therapeutics;Observational Study;Outcome;Participant;Patient Care;patient oriented;Patients;Persons;Population;prevent;Property;randomized, clinical trials;Randomized, Controlled Trials;Recommendation;Regression Analysis;Reporting;Research;Research Personnel;Research Project Grants;Risk;Risk Estimate;Sampling;simulation;standard of care;Statistical Data Interpretation;Statistical Methods;statistics;Surveys;survival outcome;Testing;Time;Translating;Translations;treatment effect;treatment group;treatment risk;user-friendly;webinar;Work

PROJECT_TITLE: Survival Data Analysis using general censoring-free incident rate

STUDY_SECTION: ASPA

STUDY_SECTION_NAME: Analytics and Statistics for Population Research Panel A Study Section[ASPA]


ORG_DEPT: PHYSIOLOGY

PHR: Project Narrative This project focuses on the mechanisms that control actin monomer (G-actin) addition/dissociation at the polymerizing and depolymerizing ends of the actin filament (F-actin), key events that affect all cellular functions of actin in health and disease, including cell motility, muscle contraction, cancer metastasis, and cardiomyopathies. Using a broad spectrum of experimental approaches, ranging from cryo-electron microscopy and mutagenesis to cellular knockouts, the goal is to provide a structural-functional understanding of the mechanisms that control filament end dynamics in health and disease.

PI_NAMEs: DOMINGUEZ, ROBERTO  (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TERMS: Acceleration;Actins;Address;ADP-G-actin;Affect;Affinity;Amino Acids;ATP Hydrolysis;ATP phosphohydrolase;ATP-G-actin;Binding;Binding Proteins;Biochemical;Biological Assay;Cardiomyopathies;Catalytic Domain;Cell Line;cell motility;Cell Physiology;Cells;cofilin;Collaborations;Complex;CRISPR/Cas technology;Cryoelectron Microscopy;Cytoplasm;Data;dimer;Dimerization;Disease;Dissociation;Educational process of instructing;Endocytosis;Equilibrium;Eukaryotic Cell;Event;Exocytosis;experimental study;F-Actin;Family member;Filament;Funding;G Actin;Gelsolin;Goals;Grant;Head;Health;Heart Diseases;Human;Hydrolysis;innovation;inorganic phosphate;Kinetics;Knock-out;Leucine-Rich Repeat;Malignant Neoplasms;Mammalian Cell;Membrane;Methods;Microfilaments;Microfluidics;Modeling;Molecular Conformation;monomer;Motility;Muscle;Muscle Contraction;Mutagenesis;mutant;Neoplasm Metastasis;Nervous System Disorder;Organelles;Paris, France;platelet protein P47;polymerization;Polymers;Post-Translational Protein Processing;Process;Proteins;Proteomics;Protomer;Reaction;reconstruction;Recycling;Regulation;Research;RNA Cap-Binding Proteins;scaffold;Side;Site;Structure;success;Tail;Testing;treadmill;tropomodulin;Tropomyosin;vasodilator-stimulated phosphoprotein;Work

PROJECT_TITLE: Structural-Functional Mechanisms Controlling Actin Filament Barbed and Pointed End Dynamics

STUDY_SECTION: MSFC

STUDY_SECTION_NAME: Macromolecular Structure and Function C Study Section[MSFC]


NIH_SPENDING_CATS: Bioengineering;Brain Disorders;Data Science;Drug Abuse (NIDA only);Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: PROJECT NARRATIVE The proposed research in this application aims to utilize artificial intelligence-based tools to accelerate the discovery of high-quality chemical probes for studying the complex functions of G Protein-Coupled Receptors associated with drugs of abuse. This information is essential for developing effective medications for substance use disorders.

PI_NAMEs: FILIZOLA, MARTA  (contact)

PROGRAM_OFFICER_NAME: LE, HOANG VAN

PROJECT_TERMS: Acceleration;addiction;Artificial Intelligence;Binding Sites;Biological Assay;Brain;Centers for Disease Control and Prevention (U.S.);Chemicals;clinical application;Complex;Data;Data Set;Databases;deep learning;deep neural network;design;Development;Disease;Drug abuse;Drug Design;drug of abuse;Drug Targeting;effective therapy;effectiveness validation;Electronics;G-Protein-Coupled Receptors;Goals;Hybrids;improved;in silico;Individual;insight;interest;Knowledge;large datasets;Lead;Learning;Ligand Binding;Ligands;Link;Medical;medication for opioid use disorder;National Institute of Drug Abuse;neural network classifier;Neural Network Simulation;novel;novel therapeutics;opioid overdose;opioid use disorder;Overdose;overdose death;Performance;Pharmaceutical Preparations;pharmacologic;Physiological;pre-trained model;Property;Psychological reinforcement;receptor;Research;Resolution;Rewards;Scheme;screening;small molecule;small molecule libraries;Speed;structural biology;Structure;Substance Use Disorder;Therapeutic;therapeutically effective;tool;Training;transfer learning;United States;virtual

PROJECT_TITLE: AI-Accelerated Discovery of Novel Compounds for GPCRs Targeted by Drugs of Abuse

STUDY_SECTION: MSFA

STUDY_SECTION_NAME: Macromolecular Structure and Function A Study Section[MSFA]


NIH_SPENDING_CATS: Aging;Biotechnology;Breast Cancer;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Rural Health;Women's Health Research

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: Project Narrative Dr. Ciara O’Sullivan’s professional vision is to improve care for breast cancer patients through the personalization of systemic treatment options, investigation of novel therapeutics and the development of prognostic and predictive biomarkers. As an experienced clinical trialist, she is committed to being of continued service to the NCI clinical trials networks through the development of and execution of NCI funded trials, active participation in NCTN-affiliated scientific reviews and monitoring committees, supporting institutional efforts to enhance accrual of rural patients and underrepresented minorities to research studies and ultimately assuming leadership roles at Mayo Clinic and within the Alliance for Clinical Trials in Oncology. Dr. O’Sullivan’s research projects, advocacy efforts and support of the NCTN will significantly improve treatment options for patients with all BC subtypes in the short and long term, which is aligned with the NCI vision of advancing scientific knowledge to improve quality of life and overall life expectancy for these patients.

PI_NAMEs: O'SULLIVAN, CIARA C (contact)

PROGRAM_OFFICER_NAME: TAWAB-AMIRI, ABDUL

PROJECT_TERMS: Address;Advocacy;Advocate;American Society of Clinical Oncology;anti-cancer research;Breast;Breast Cancer Patient;Cancer Advocacy;cancer care;cancer subtypes;Caring;Clinic;Clinical;clinical practice;Clinical Research;Clinical Trials;Clinical Trials Design;Clinical Trials Network;Conduct Clinical Trials;Development;Developmental Therapeutics Program;Disease;Drug resistance;Early treatment;Education;Endocrine;ERBB2 gene;experience;Funding;Goals;hormone receptor-positive;improved;Industry;Institution;Institutional Review Boards;International;Investigation;investigator-initiated trial;K-Series Research Career Programs;Knowledge;Leadership;Life Expectancy;Malignant Breast Neoplasm;Malignant Neoplasms;Medical Oncologist;Medical Oncology;member;men;Metastatic breast cancer;Minority Groups;minority patient;Mission;Monitor;novel therapeutics;Oncology;patient oriented;Patient Recruitments;Patients;Pertuzumab;Phase I/II Trial;predictive marker;premature;professor;Prognostic Marker;Prospective Studies;Quality of life;Research;Research Project Grants;research study;Residual Neoplasm;Resistance;Review Committee;Role;Rural Minority;rural patients;rural underrepresented;Scientific Advances and Accomplishments;Services;Site;skills;taxane;Testing;Translational Research;Trastuzumab;treatment optimization;tumor;Underrepresented Minority;Vision;Woman;Work

PROJECT_TITLE: Developing, Implementing and Supporting NCI Clinical Trials and the National Cancer Trials Network (NCTN) in Breast Cancer and Developmental Therapeutics- A 5 Year Plan

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-1 (O1)]


NIH_SPENDING_CATS: Cancer;Childhood Leukemia;Genetics;Hematology;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: Newark

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: PROJECT NARRATIVE T-Cell Acute Lymphoblastic Leukemia (T-ALL) is a disease where relapses occur in 20-50% of cases, and these patients ultimately die from their disease, highlighting the need to discover novel therapeutic targets. Our preliminary results have identified pyruvate kinase (PKM) as a novel therapeutic target in T-ALL, thus, here we will address the role and mechanisms of PKM in T-ALL in vivo taking advantage of our unique genetic and technical tools. Our results will pave the way for improved therapeutic approaches for the treatment of T-ALL patients in the short-term.

PI_NAMEs: HERRANZ, DANIEL  (contact)

PROGRAM_OFFICER_NAME: JHAPPAN, CHAMELLI

PROJECT_TERMS: Acute Lymphocytic Leukemia;Acute T Cell Leukemia;acute T-cell lymphoblastic leukemia cell;Address;Adult;Aftercare;antileukemic activity;antileukemic agent;Automobile Driving;Cancer Control;Cell Line;Cell Lineage;chemotherapeutic agent;chemotherapy;Child;Childhood;Clinic;Clinical;Clinical Trials;Clinical Trials Design;Combined Modality Therapy;Complex;conditional knockout;CRISPR screen;Detection;Disease;early phase clinical trial;effective therapy;Enzymes;Epigenetic Process;epigenetic profiling;Exons;experimental study;gamma secretase;Gene Combinations;Gene Expression;Gene Expression Profiling;Generations;Genetic;Genetic Transcription;Glutaminase;Glycolysis;Goals;Hematologic Neoplasms;Hematology;Hematopoietic;Human;improved;In Vitro;in vivo;inhibitor;Investigational Therapies;kinase inhibitor;Knock-out;Knockout Mice;leukemia;leukemia treatment;Leukemic Cell;loss of function;Lymphoid;Mediating;Metabolic;metabolomics;Modeling;Mus;Mutation;new therapeutic target;NOTCH1 gene;novel;novel therapeutic intervention;Oncogenic;Outcome;Pathway interactions;Patients;Pharmaceutical Preparations;pharmacologic;Play;programs;Protein Isoforms;Pyruvate Kinase;rational design;Recurrent disease;Refractory;Regimen;Relapse;Resistance;response;Role;Route;Safety;secretase;Signal Transduction;standard of care;synergism;T-Lymphocyte;Therapeutic;Therapeutic Effect;therapeutic target;tool;Toxic effect;translational applications;treatment response;tumor;tumor metabolism

PROJECT_TITLE: The role of pyruvate kinase as a therapeutic target in T-ALL

STUDY_SECTION: CCB

STUDY_SECTION_NAME: Cancer Cell Biology Study Section[CCB]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Clinical Research;Microbiome;Obesity;Prevention;Substance Misuse

ORG_CITY: FARGO

ORG_NAME: SANFORD RESEARCH NORTH

ORG_STATE: ND

PHR: Biobehavioral Mechanistic Model of Alcohol Use Following Bariatric Surgery: The BREW ME Model Project Narrative The proposed project will test a novel model to explain the observed relationship between metabolic and bariatric surgery and post-operative hazardous alcohol use. Specifically, we use a combined clinical laboratory and ecological momentary assessment approach to explore the mechanistic role of the gut microbiome and the reward value of alcohol on hazardous alcohol use 2 years following surgery.

PI_NAMEs: ENGEL, SCOTT G (contact);HEINBERG, LESLIE J.;STEFFEN, KRISTINE JAYNE

PROGRAM_OFFICER_NAME: AKBAR, MOHAMMED

PROJECT_TERMS: Alcohol abuse;Alcohol consumption;alcohol effect;alcohol monitoring;alcohol use disorder;Alcohols;Animal Model;Animals;Automobile Driving;bariatric surgery;Behavioral;biobehavior;Biological;Body Weight decreased;Brain;Clinical;Clinical Research;Communication;comorbidity;Complex;Complication;design;Development;drinking behavior;Ecological momentary assessment;Environment;experience;Frequencies;Gastrectomy;Gastric Bypass;General Population;Genes;gut health;gut microbiome;gut microbiota;gut-brain axis;Health;improved;indexing;Individual;individual patient;Intervention;Laboratories;Literature;longitudinal design;Measures;Metabolic;Methodology;Methods;microbial;microbiome;microbiome composition;Minority;Modeling;monitoring device;Morbid Obesity;Neurobiology;novel;Obesity;Operative Surgical Procedures;Outcome;Paper;Patient Self-Report;Patients;Play;Population;Postoperative Period;Prevention;Procedures;Process;programs;prospective;psychologic;Public Health;Publishing;Recurrence;Reporting;Research;reward processing;Rewards;Risk;Risk Reduction;Role;Severities;surgery outcome;Surgical Models;System;Testing;therapy development;Time;United States;Work

STUDY_SECTION: ARM

STUDY_SECTION_NAME: Addiction Risks and Mechanisms Study Section[ARM]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Infectious Diseases;Lung;Orphan Drug;Pediatric;Rare Diseases;Tuberculosis

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: PROJECT NARRATIVE Children under 5 years of age account for ~50% of the 1.2 million new cases of pediatric TB each year, but are least likely to be diagnosed as they often present with disseminated or extrapulmonary TB and paucibacillary disease, and are therefore often missed by respiratory sampling, and are at highest risk of death without prompt treatment. To meet the need of non-sputum diagnostic tools for TB in young children, we developed an assay that detects Mycobacterium tuberculosis (Mtb) cell free DNA (cfDNA) coupled with CRISPR technology (CRISPR-TB) to improve sensitivity using small blood volumes. The proposed study will utilize samples from an ongoing large well-characterized cohort of children with suspected TB as well as additional cohorts of adults with confirmed TB and their asymptomatic household controls, and recently BCG-immunized asymptomatic infants to evaluate CRISPR-TB diagnostic performance (Aim 1) including longitudinal evaluation for treatment response (Aim 2), and extend evaluation to urine samples (Aim 3).

PI_NAMEs: LACOURSE, SYLVIA  (contact)

PROGRAM_OFFICER_NAME: LACOURCIERE, KAREN A

PROJECT_TERMS: 2 year old;5 year old;Adult;aspirate;Biological;Biological Assay;Blood;Blood specimen;Blood Volume;cell free DNA;Cessation of life;Child;Childhood;Classification;Clinical;clinical diagnosis;Clinical Treatment;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;Coupled;CRISPR/Cas technology;Data;Detection;detection assay;Devices;Diagnosis;Diagnostic;diagnostic strategy;diagnostic tool;Disease;Early Diagnosis;Early identification;Enrollment;Equation;Equipment;Evaluation;Feces;high risk;HIV;Hospitalization;Household;Human Resources;Immunize;improved;Infant;Infrastructure;Lateral;Modeling;molecular diagnostics;Monitor;Morbidity - disease rate;mortality;mortality risk;mycobacterial;Mycobacterium tuberculosis;Paper;Participant;Performance;peripheral blood;point of care;Population;portability;preclinical evaluation;Prevalence;Prospective cohort;rapid detection;Reading;Reference Standards;repository;respiratory;response;Sampling;Signal Transduction;Specificity;Specimen;Sputum;Stomach;Surrogate Markers;Testing;Time;Training;Treatment Failure;treatment response;Tuberculosis;Tuberculosis diagnosis;tuberculosis treatment;Urine

PROJECT_TITLE: CRISPR-TB for pediatric TB diagnosis and treatment response

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 DCAI-M (02)]