ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Emergency Care;Patient Safety;Physical Injury - Accidents and Adverse Effects

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: PROJECT NARRATIVE The current standard of care in trauma transfusion is component therapy; however, whole blood offers several potential clinical and logistical advantages and is increasingly being used in transfusion despite a lack of well-powered clinical trials. The “Trauma Resuscitation with Group O Whole Blood Or Products” (TROOP) trial will use a Bayesian, group-sequential, combined non-inferiority/superiority design, and pre-planned cost-effectiveness analysis of 1,100 patients to determine whether whole blood is non-inferior and/or superior to component therapy with respect to mortality and safety. The TROOP trial is well-positioned to improve mortality and reduce the number of preventable trauma deaths.

PI_NAMEs: DESANTIS, STACIA  (contact)

PROGRAM_OFFICER_NAME: KINDZELSKI, ANDREI L

PROJECT_TERMS: Accident and Emergency department;Adverse event;Alabama;Annual Reports;authority;Biometry;Blood;Blood Platelets;Blood Transfusion;Blood Volume;Budgets;Case Report Form;Cessation of life;Clinical;clinical center;Clinical Data;Clinical effectiveness;Clinical Management;Clinical Trials;Clinical Trials Data Monitoring Committees;Collaborations;Collection;Communication;Communities;compare effectiveness;computerized data processing;Conflict of Interest;Cost Effectiveness Analysis;Data;Data Collection;Data Coordinating Center;data dissemination;data management;Data Science;Data Set;design;Development;Documentation;effectiveness evaluation;electronic data;electronic data capture system;Elements;Eligibility Determination;Enrollment;Ensure;Erythrocytes;Event;Exhibits;experience;follow-up;Funding;Goals;Grant;Health Sciences;Hemorrhagic Shock;Hour;Human Resources;improved;innovation;Institutional Review Boards;Leadership;Manuals;meetings;member;Methodology;Monitor;mortality;National Heart, Lung, and Blood Institute;Observational Study;operation;organizational structure;Patients;Phase;Plasma;Policies;Positioning Attribute;primary outcome;Principal Investigator;Probability;Procedures;Protocols documentation;Publications;Quality Control;randomized, clinical trials;recruit;remote monitoring;Reporting;Research;Resources;Resuscitation;Role;Safety;Schedule;secondary outcome;Secure;severe injury;Site;Specific qualifier value;standard of care;symposium;System;Testing;Texas;Time;timeline;Transfusion;transfusion medicine;Trauma;trauma centers;Trauma patient;trial design;United States Food and Drug Administration;Universities;Validation;Voting;web site;Whole Blood;working group

PROJECT_TITLE: 2/2 Trauma Resuscitation with Group O Whole Blood or Products (TROOP)

STUDY_SECTION: CLTR

STUDY_SECTION_NAME: Clinical Trials Review Study Section[CLTR(JA)]


ADMINISTERING_IC: CA

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

ORG_CITY: NASHVILLE

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PI_NAMEs: SUITER, SARAH  V (contact)

PROJECT_TERMS: Advanced Malignant Neoplasm;Advisory Committees;Cancer Center;cancer health disparity;Cancer health equity;Collaborations;Collection;Communication;Data;Data Analyses;Data Collection;data management;Data Reporting;Decision Making;design;Development;Education;Ensure;Evaluation;Feedback;Fostering;Funding;Goals;Grant;Health;health inequalities;improved;innovation;Institution;Investments;Leadership;Logic;Malignant Neoplasms;Measurable;Measures;medical schools;Methods;Modeling;Monitor;Nature;Outcome;Output;Performance;Practice Management;Principal Investigator;Process;Program Evaluation;programs;Publications;Quality of life;Recommendation;recruit;Research;Research Personnel;Resources;Respondent;Services;Students;success;Teacher Professional Development;Techniques;Tennessee;The Vanderbilt-Ingram Cancer Center at the Vanderbilt University;theories;Time;tool;Universities;Work

PROJECT_TITLE: Planning and Evaluation Core


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Women's Health Research

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: CEC – PROJECT NARRATIVE The CEC Core of the Colorado SCORE will focus on funding, mentoring, and training early career scientists who want to focus their research in the important and innovative area of sex differences. The CEC Core will provide team mentoring, hands-on research experience and training in the academic research skills, career development skills and methods of studying sex differences that will promote the development of a workforce in the field of sex differences research. Success in this endeavor will mean that health and disease in women and men will be optimally studied so that medical research is benefiting everyone to the highest level possible.

PI_NAMEs: REGENSTEINER, JUDITH G. (contact)

PROJECT_TERMS: Academic skills;Aging;Area;Award;Bioenergetics;Budgets;cardiometabolism;career;career development;Clinical;Clinical Sciences;Colorado;cost;Dedications;Development;Disease;early-career faculty;Educational Curriculum;Elements;Endocrinology;Environment;evidence base;Exercise;experience;Family;Feedback;Funding;Gender;Goals;gonad function;Grant;Guidelines;hands on research;Health;Home;Individual;innovation;Institution;Interdisciplinary Study;interest;Investigation;Manuscripts;Mediation;Medical Research;meetings;men;Mentored Clinical Scientist Development Program;Mentors;Metabolism;Methods;multidisciplinary;Outcome;Peer Review;Pilot Projects;Process;programs;recruit;Research;Research Methodology;Research Personnel;Research Project Grants;Running;Schedule;Scientist;sex;Sex Differences;skill acquisition;skills;success;Talents;Time;Training;Training Activity;training opportunity;Translational Research;United States National Institutes of Health;Wages;Woman;Women's Health;women's reproductive health;Work;Writing

PROJECT_TITLE: Career Enhancement Core

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-EMS-A]


ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

NIH_SPENDING_CATS: Cancer;Digestive Diseases;Pancreatic Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: BALTIMORE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: PROJECT NARRATIVE The primary cause of cancer-related mortality is distal metastasis, particularly in pancreatic cancer patients, where the high incidence of extra-pancreatic metastasis upon diagnosis results in poor patient outcomes. While the genetic mutations that cause pancreatic cancer have been extensively studied, there has been little work done to explain the mechanisms behind metastatic tumor growth, and as a consequence, limited treatment modalities to treat this disease. Here, we have identified Gstt1 as a regulator of metastasis, and this proposal will provide insight into Gstt1-driven vulnerabilities to treat pancreatic cancer metastasis.

PI_NAMEs: FERRER, CHRISTINA  (contact)

PROGRAM_OFFICER_NAME: AULT, GRACE S

PROJECT_TERMS: Acceleration;Address;Affect;Agar;Anchorage-Independent Growth;Automobile Driving;Biological Assay;Breast;breast cancer metastasis;cancer cell;Cancer Etiology;cell growth;Cell Line;Cells;Cessation of life;Characteristics;Circulation;Data;Development;Diagnosis;differential expression;Disease;Disease Progression;Distal;DNA Sequence Alteration;Doxycycline;Early identification;efficacy testing;experimental study;Future;Gene Expression Profile;Genes;Genetically Engineered Mouse;Glutathione S Transferase A;Glutathione S-Transferase;Glutathione Transferase Inhibitor;Growth;Human;human tissue;Hydrophobicity;In Vitro;in vivo;Incidence;inhibitor;insight;Invaded;knock-down;Lesion;Liver;lung metastatic;Maintenance;Malignant Breast Neoplasm;Malignant neoplasm of pancreas;Malignant Neoplasms;Mediating;Metastatic Adenocarcinoma;Modality;Modeling;Molecular;mortality;mouse model;Neoplasm Metastasis;non-genetic;novel;Outcome;Pancreas;Pancreatic Adenocarcinoma;pancreatic cancer patients;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma model;Patient-Focused Outcomes;Patients;Pattern;Play;pre-clinical;Primary Neoplasm;Proteins;Reduced Glutathione;Research;Role;self-renewal;small hairpin RNA;small molecule inhibitor;Solid Neoplasm;Specimen;Stains;Survival Rate;System;Testing;Therapeutic;therapeutic target;Tissue-Specific Gene Expression;Tissues;TP53 gene;transcriptome sequencing;tumor;tumor growth;Validation;Work

PROJECT_TITLE: Role of Gstt1 in metastatic maintenance and self-renewal in PDA

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Transition to Independence Study Section (I)[NCI-I]


ADMINISTERING_IC: GM

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding

ORG_CITY: LEXINGTON

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: NARRATIVE The overarching goal of the University of Kentucky (UK) SuRE Resource Center is to build research capacity at SuRE-eligible institutions, recognizing the vital contribution these colleges and universities make to the nation's research enterprise. Through a series of webinars and other training modalities, direct consultation, a competitive seed grant program to create or enhance offices of sponsor projects (OSPs), and biennial conferences, experienced UK faculty and research support staff will assist faculty and OSP staff at SuRE- eligible institutions prepare and submit competitive NIH grants applications, with an emphasis on SuRE and SuRE-First awards. Multiple methods will be used to collect and analyze data to measure the success of this center.

PI_NAMEs: MURPHY, MICHAEL PAUL;SPEAR, BRETT T (contact)

PROGRAM_OFFICER_NAME: CUPIT, PAULINE

PROJECT_TERMS: Applications Grants;Area;Authorship;Award;Biomedical Research;career;college;Communication;Communities;Consultations;Data;Educational workshop;Eligibility Determination;Employment;Ensure;expectation;experience;Face;Faculty;faculty mentor;faculty support;Feedback;First Independent Research Support and Transition Awards;Fostering;Funding;Goals;Grant;Growth;human disease;Individual;Infrastructure;Institution;Kentucky;Knowledge;Link;Marketing;Measures;meetings;Mentors;Methods;Minority-Serving Institution;Modality;National Institute of General Medical Sciences;next generation;Outcome;peer;Population;Preparation;Process;programs;Publications;Questionnaires;Research;Research Infrastructure;Research Personnel;Research Project Grants;Research Support;Resources;Schools;Science;Series;Services;Site;skills;social media;student conference;student mentoring;Students;success;symposium;Training;United States;United States National Institutes of Health;Universities;webinar;Writing

PROJECT_TITLE: University of Kentucky SuRE Resource Center


ADMINISTERING_IC: DK

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Diabetes;Digestive Diseases;Liver Disease;Nutrition;Obesity;Orphan Drug;Rare Diseases

ORG_CITY: Menlo Park

ORG_NAME: ORSOBIO, INC.

ORG_STATE: CA

PHR: Narrative  Patients with lipodystrophies exhibit hypertriglyceridemia, severe insulin resistance, diabetes, and fatty liver, and have limited treatment options. We have identified a lead small-molecule drug, TLC-1235, based on extensive biological characterization in relevant animal models of disease to address this condition with very high unmet medical need. During this project, we will carry out activities to enable preparation of an Investigation New Drug (IND) application to the Food and Drug Administration (FDA).

PI_NAMEs: MYERS, ROBERT PAUL (contact);VIJAYAKUMAR, ARCHANA

PROGRAM_OFFICER_NAME: COOKE, BRAD

PROJECT_TERMS: 2,4-Dinitrophenol;Achievement;Address;Adenosine Triphosphate;Adverse effects;Animal Disease Models;Animals;Biological;Body Weight decreased;Canis familiaris;Cell membrane;Clinical Research;Compensation;controlled release;Data;Diabetes Mellitus;Diglycerides;Dinitrophenols;Disease;Dose;Drug Interactions;Drug Kinetics;drug metabolism;Dyslipidemias;effective therapy;Electron Transport;Energy Metabolism;Exhibits;Familial generalized lipodystrophy;fatty acid oxidation;Fatty Liver;first-in-human;Formulation;Funding;good laboratory practice;Hepatic;Homeostasis;human study;Hyperthermia;Hypertriglyceridemia;improved;inflammatory marker;Injury;Inner mitochondrial membrane;Insulin Receptor;Insulin Resistance;insulin sensitivity;Investigation;Investigational Drugs;Investigational New Drug Application;Lead;Leptin;Leptin deficiency;Link;Lipids;Lipodystrophy;Liver;manufacture;Medical;Membrane Lipids;Metabolic;Mitochondria;Modeling;Muscle;No-Observed-Adverse-Effect Level;Non-Insulin-Dependent Diabetes Mellitus;nonalcoholic steatohepatitis;novel strategies;novel therapeutics;Nutrient;Oral;oxidation;Pathway interactions;Patients;Pharmaceutical Preparations;Pharmacology;Pharmacology Study;Phase;Pre-Clinical Model;Preparation;Production;programs;Protein Kinase;Protons;Rattus;Reactive Oxygen Species;Receptor Signaling;Rights;Risk;Safety;small molecule;systemic toxicity;Therapeutic;Therapeutic Index;Time;Toxicology;Treatment Efficacy;Triglycerides;United States Food and Drug Administration;Universities;Work

PROJECT_TITLE: TLC-1235, a controlled-release mitochondrial protonophore (CRMP), for the reversal of insulin resistance in patients with severe lipodystrophy


ADMINISTERING_IC: HD

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Pediatric

ORG_CITY: LAWRENCE

ORG_NAME: UNIVERSITY OF KANSAS LAWRENCE

ORG_STATE: KS

PHR: PROJECT NARRATIVE This research seeks to collect basic information about the development of learning in infancy: how learning develops from 6 to 18 months of age, whether infants who learn, remember, and relearn quickly on one learning task or at one age also learn, remember, and relearn quickly on another task or at another age. Finally, this work will establish whether infant learning is related to cognitive and language development at 2 years of age. This research is relevant to the identification of infants at risk for developmental disability and delay, and has the potential to improve the evaluation of attempts to enhance human development with early interventions.

PI_NAMEs: COLOMBO, JOHN A. (contact);CUEVAS, KIMBERLY S

PROGRAM_OFFICER_NAME: MACHLIN, LAURA STONER

PROJECT_TERMS: 2 year old;Affective;Age;Age Months;Animals;Area;Behavior;Behavior Control;Behavioral Sciences;Clinical Trials;Cognition;Cognitive;cognitive development;cognitive function;conditioning;Development;Developmental Course;Developmental Delay Disorders;Developmental Disabilities;early childhood;Early Intervention;Environment;Evaluation;Extinction;Future;Goals;Human;Human Development;improved;Individual;Individual Differences;individual variation;infancy;Infant;Language Development;language outcome;Language Tests;learned behavior;Learning;life span;Literature;Longitudinal Studies;Measures;member;Motor;neglect;Operant Conditioning;Organism;Outcome;outcome prediction;Outcome Study;Perception;Performance;pre-clinical;preclinical study;Property;Psychological reinforcement;Psychometrics;Publishing;reinforcer;Research;Research Personnel;response;Risk;Sampling;Science;social;Speed;Standardization;standardize measure;System;Testing;Training;virtual;Work

PROJECT_TITLE: Psychometrics and Predictive Validity of Infant Learning

STUDY_SECTION: BRLE

STUDY_SECTION_NAME: Biobehavioral Regulation, Learning and Ethology Study Section[BRLE]


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Endocrine Disruptors;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infertility;Pediatric;Pregnancy;Prevention

ORG_CITY: NEW YORK

ORG_DEPT: PEDIATRICS

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: PROJECT NARRATIVE We propose to enroll pregnant women, children and conceiving partners from the NYU Children’s Health and Environment Study into the Environmental Influences on Child Health Outcomes Program. Findings from this program will guide the development of policies, practices and procedures to support the health and well-being of future generations to come.

PI_NAMEs: TRASANDE, LEONARDO  (contact)

PROGRAM_OFFICER_NAME: ARTEAGA, SONIA S

PROJECT_TERMS: absorption;Air Pollutants;Area;Aromatic Polycyclic Hydrocarbons;Asian;Birth;Black race;chemical association;Chemical Exposure;Chemicals;Child;Child Health;Clinic;cohort;Cohort Studies;Collection;Conceptions;Couples;COVID-19;COVID-19 pandemic;Data;Data Collection;design;Development;development policy;digital platform;Discipline of obstetrics;Embryo;Enrollment;Environment;Environmental Exposure;Environmental Health;experience;Exposure to;Fertility;fetal;Fetal Growth;follow-up;Funding;Future Generations;Generations;Growth;Health;heterocyclic aromatic amines;Hispanic;Human;infancy;Infant;infertility treatment;innovation;International;Laboratories;Lead;Life;Long-Term Effects;Low Birth Weight Infant;Measures;Mediating;medical schools;Melamine;Mothers;National Institute of Environmental Health Sciences;New York City;novel;Obesity;Organophosphates;Outcome;pandemic disease;Participant;participant retention;patient engagement;Patients;Personal Satisfaction;Persons;Pesticides;Phase;phthalates;Pilot Projects;Plethysmography;postnatal;Pregnancy;Pregnancy Outcome;pregnant;Pregnant Women;Premature Birth;prenatal;prenatal exposure;Procedures;Productivity;programs;Protocols documentation;public health insurance;Publications;Recommendation;recruit;Research;Resources;Risk Factors;Roentgen Rays;Sampling;SARS-CoV-2 infection;Science;Subfecundity;System;Time;time-to-pregnancy;Translations;United States National Institutes of Health;Urine;Visit;wearable device;working group

PROJECT_TITLE: The NYU Children’s Health & Environment Study: an ECHO Cohort

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-EPH-S(50)R]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Social Determinants of Health

PI_NAMEs: DAHLMAN, KIMBERLY BROWN (contact)

PROJECT_TERMS: African American;American;anti-cancer research;Biology;Cancer Biology;Cancer Center;cancer health disparity;career;Career Choice;career development;Chemistry;Clinical;Cognitive;Communities;Community Developments;Community of Practice;Development;Disparity;Doctor of Philosophy;doctoral student;education research;Educational workshop;Ensure;Environment;Evolution;experience;faculty mentor;Goals;graduate student;Growth and Development function;high school;High School Student;innovation;Institution;interest;Laboratory Research;Latinx;learning materials;Maintenance;Malignant Neoplasms;Master of Public Health;medical schools;Medical Students;Mentors;Pathway interactions;peer coaching;Population;Population Heterogeneity;Population Sciences;programs;Psychosocial Assessment and Care;psychosocial resources;recruit;Research;Research Personnel;Research Project Grants;Research Support;Resources;Schools;Science;Self Efficacy;Series;social;student participation;Students;success;Talents;Tennessee;The Vanderbilt-Ingram Cancer Center at the Vanderbilt University;theories;translational cancer research;undergraduate student;Underrepresented Minority;underrepresented minority student;Underrepresented Students;Universities

PROJECT_TITLE: Research Education Core


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Dementia;Neurodegenerative;Physical Activity;Physical Rehabilitation;Prevention;Rehabilitation

ORG_CITY: GREENSBORO

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF NORTH CAROLINA GREENSBORO

ORG_STATE: NC

PHR: Project Narrative  The limited success of current approaches to promote physical activity in the US older adult population is an important public health problem. Low adherence to the national physical activity guidelines can lead to increased risk of cognitive decline and dementias. Our phased, innovative approach will address this issue by using a novel, evidence-based music intervention that is designed to enhance hedonic (pleasure-seeking) motivation for physical activity behavior change among low-active older adults, a growing population at risk.

PI_NAMEs: ETNIER, JENNIFER L (contact);PARK, KYOUNG SHIN

PROGRAM_OFFICER_NAME: HARRELL, ERIN

PROJECT_TERMS: Accelerometer;Accent;Acclimatization;Acoustic Stimulation;Acute;Adherence;Adult;Aerobic Exercise;Affect;Affective;Age;aged;Alzheimer's Disease;Alzheimer's disease risk;auditory stimulus;Behavior;behavior change;behavioral response;Cardiac rehabilitation;curative treatments;Dementia;design;displeasure;Ecological momentary assessment;evidence base;Exercise;exercise intervention;exercise program;exercise training;Exertion;Expenditure;experience;Failure;falls;Feasibility Studies;Fostering;Frequencies;Future;Goals;Guidelines;Health Benefit;Health Care Costs;hedonic;Home;Impaired cognition;improved;innovation;Intervention;lifestyle intervention;Maintenance;Measures;Mediating;Mediator;Meta-Analysis;middle age;modifiable risk;Motivation;Movement;Music;Music Therapy;negative affect;non-demented;novel;novel strategies;older adult;older patient;Outcome;Participant;Patient Self-Report;Periodicity;Persons;Phase;Physical activity;physical inactivity;Physiologic pulse;pleasure;Population;Populations at Risk;prevent;programs;psychologic;Psychological Tests;Public Health;Randomized;Research;response;Risk;Risk Factors;Risk Reduction;Sampling;satisfaction;strength training;success;Testing;Theoretical model;Training;Translating;treatment adherence;Walking;Withdrawal;Work

PROJECT_TITLE: Unraveling the mechanisms of a novel music intervention for physical activity promotion in older adults


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Infectious Diseases;Microbiome

ORG_CITY: PHILADELPHIA

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Narrative The secretion of sebum, a lipid-rich substance that promotes skin barrier function, can be controlled by cells of the immune system (T cells), which we call the immune-sebum axis. We propose that the skin microbiota act as the trigger for T cell activation to promote the immune-sebum axis, which forms a feedback mechanism to maintain homeostasis of the skin microenvironment, whereby skin microbes promote sebum secretion, which in turn controls their growth. Understanding the potential interplay amongst the skin microbiome, skin T cells, and sebaceous glands will yield insight into how the skin maintains optimal skin barrier function.

PI_NAMEs: GRICE, ELIZABETH ANNE;KAMBAYASHI, TAKU  (contact)

PROGRAM_OFFICER_NAME: UNDALE, ANITA H

PROJECT_TERMS: Adaptive Immune System;Adaptor Signaling Protein;Adoptive Transfer;Affect;Androgen Receptor;Androgens;anti-microbial peptide;Antigens;antimicrobial;Atopic Dermatitis;Biology;Cell Count;Cell Line;Cells;Cellular biology;Cellular Immunology;Chemicals;commensal microbes;Cutaneous;cytokine;Cytokine Receptors;Data;defense response;Disease;Ensure;Environment;Epithelium;Exhibits;Family;Feedback;gain of function;Gene Expression;Genes;Genetic;Germ-Free;Gland;gland development;Goals;Growth;Health;Homeostasis;Hormones;Human;Hypersensitivity skin testing;IL1R1 gene;Immune;Immune system;Immunologics;in vivo;Infection;Infectious Skin Diseases;Innate Immune System;insight;Interleukin-1;Interleukin-1 Receptors;Interleukin-13;Interleukin-4;Investigation;keratinocyte;Lipids;loss of function;Mediating;Microbe;microbiota;microbiota composition;migration;Modeling;Molecular and Cellular Biology;Molecular Immunology;multidisciplinary;Mus;novel;overexpression;pathogen;Pathogenesis;Pathogenicity;pharmacologic;Phenotype;Process;Proliferating;receptor;Regulation;repaired;Reporter;Reporting;Research;response;Role;Sebaceous Glands;Sebum;Signal Pathway;Signal Transduction;Skin;skin barrier;skin microbiome;skin microbiota;Source;Stains;Staphylococcus aureus;Staphylococcus epidermidis;T cell therapy;T-Cell Activation;T-Lymphocyte;Testing;Toll-like receptors;TSLP gene;Water

PROJECT_TITLE: Skin microbiome regulation of the sebum-immune axis


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Rural Health;Social Determinants of Health

PI_NAMEs: WINKFIELD, KAREN MARIE (contact)

PROJECT_TERMS: Academia;Acceleration;Address;Affect;anti-cancer research;Applications Grants;Area;biobank;Bioinformatics Shared Resource;Biometry;Black race;Cancer Burden;cancer care;Cancer Center;cancer health disparity;Cancer health equity;cancer prevention;cancer risk;Censuses;Clinical;Clinical Research;Clinical Trials;Collaborations;Communication;Communities;community advisory board;community building;community collaboration;community engaged research;community engagement;community organizations;Community Outreach;community partners;community research;County;design;Development;Dissemination and Implementation;dissemination science;Education and Outreach;education research;Educational Materials;Ensure;Equity;ethnic minority;Evaluation;evidence base;Faculty;Feedback;Fostering;Foundations;Funding;Goals;Grant;health equity;Health equity research;health inequalities;Healthcare;implementation science;innovation;Institution;interest;Knowledge;Learning;Learning Module;Maintenance;Malignant neoplasm of ovary;Malignant neoplasm of prostate;Malignant Neoplasms;medical schools;meetings;member;men;Mentorship;Methodology;metropolitan;Minority Participation;mobile application;mortality disparity;Multicultural Education;new technology;online resource;outreach;Outreach Research;Ownership;Participant;Pathology;Patients;Pilot Projects;Policies;Population;Population Research;Prevention;Process;programs;Public Health Education;racial minority;Research;Research Personnel;Research Project Grants;research study;Resource Sharing;Resources;Rural Community;Scanning;social media;Source;Students;Support Groups;survivorship;Technology;Tennessee;Testing;Training Activity;training opportunity;underserved community;Universities;web-based tool;Work

PROJECT_TITLE: Cancer Outreach Core


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: Project Narrative The Federal Drug Administration sets strict limits on how MRIs can operate to avoid any possible stimulation of the heart. However, the lack of data on how temporally changing magnetic fields interact with the heart hampers our ability to know the detailed limits that should be applied and has led to a necessarily conservative approach which restricts the operation of the latest generation of MRI gradient systems. To address this, we perform the first measurement of cardiac magneto-stimulation on pigs, a widely used animal model for the human cardiovascular system, and develop a detailed modeling pipeline of the cardiac magneto-stimulation phenomenon.

PI_NAMEs: GUERIN, BASTIEN  (contact);NGUYEN, CHRISTOPHER T

PROGRAM_OFFICER_NAME: WANG, SHUMIN

PROJECT_TERMS: Accounting;Address;Animal Model;Animals;Arrhythmia;Biomedical Engineering;Canis familiaris;Cardiac;cardiac magnetic resonance imaging;Cardiac Volume;Cardiovascular system;Cells;Chest;Collaborations;Computer Models;Confidence Intervals;connectome;Coupled;Data;design and construction;Devices;Diffusion Magnetic Resonance Imaging;electric field;Electrodes;Electromagnetic Fields;Electromagnetics;Electrophysiology (science);Evaluation;Event;experimental study;Family suidae;Fatty acid glycerol esters;Fiber;Frequencies;Generations;Geometry;Goals;Heart;Heart Abnormalities;Heart Arrest;Human;Image;improved;Individual;Ion Channel;magnetic field;Magnetic Resonance Imaging;Measurement;Measures;Methodology;Methods;Modeling;MRI Scans;multidisciplinary;Myocardium;Nerve;operation;Pacemakers;Patients;Peripheral Nerve Stimulation;Peripheral Nerves;Pharmaceutical Preparations;physiologic model;porcine model;Positioning Attribute;Process;programs;Publishing;Recommendation;Research Project Grants;Resolution;response;Safety;simulation;Speed;Structure of purkinje fibers;System;Techniques;Technology;Time;tool;Update;Validation;Variant;Ventricular;Water;Work

PROJECT_TITLE: Modeling, measurement and prediction of cardiac magneto-stimulation  thresholds

STUDY_SECTION: ITD

STUDY_SECTION_NAME: Imaging Technology Development Study Section[ITD]


NIH_SPENDING_CATS: Behavioral and Social Science;Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Palliative Care;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

PI_NAMEs: FRIEDMAN, DEBRA L. (contact)

PROJECT_TERMS: Address;anti-cancer research;Area;base;behavioral health;Behavioral Sciences;Biometry;Breast;Breast Cancer Risk Factor;cancer care;Cancer Center;Cancer Control;cancer diagnosis;cancer health disparity;cancer subtypes;cancer therapy;care delivery;Clinical;clinical infrastructure;Clinical Research;clinical training;Clinical Trials;cohort;Collaborations;Collection;community advisory board;Community Developments;community engaged research;community engagement;comorbidity;Conduct Clinical Trials;Continuity of Patient Care;control trial;Coupled;Data;Death Rate;design;Disease;Disparity;doctoral student;Early Diagnosis;education research;Educational Materials;Eligibility Determination;Enrollment;Epidemiology;Equity;ethnic minority;Etiology;Evaluation;Exclusion;Exclusion Criteria;Experimental Designs;Future;General Hospitals;Goals;Health;Healthcare;improved;Incidence;inclusion criteria;Information Dissemination;Infrastructure;Institution;Intervention;Intervention Trial;Investigator-Initiated Research;Learning;Link;Logic;Longitudinal cohort;Lung;lung cancer screening;Malignant Breast Neoplasm;Malignant Neoplasms;medical schools;Mentorship;Methods;metropolitan;Minority Access;Mission;Modeling;neoplasm registry;Observational Study;Oncology;Outcome;outreach;Palliative Care;Participant;Pathology;patient population;Patient Recruitments;Patient-Focused Outcomes;Patients;population based;Population Research;Population Sciences;pre-doctoral;Prevention;prospective;Public Hospitals;racial minority;Recording of previous events;recruit;Research;Research Personnel;Research Project Grants;research study;Research Support;Resource Sharing;Resources;Risk;Risk Assessment;Risk Factors;safety net;Science;Screening for cancer;Self Management;success;Supportive care;survivorship;Tennessee;Therapeutic Clinical Trial;Time;tobacco control;Training;trial design;Trust;Underserved Population;Universities;Woman;Work

PROJECT_TITLE: Core 1: PRACTICE Shared Resource Core


NIH_SPENDING_CATS: Biotechnology;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

PI_NAMEs: SHYR, YU  (contact)

PROJECT_TERMS: Address;Bioinformatics;Bioinformatics Shared Resource;Biometry;Biostatistics Shared Resource;Cancer Center;cancer health disparity;Clinical;Clinical Trials;Collaborations;Computer software;Data Analyses;data cleaning;data quality;data visualization;database design;design;Development;Educational workshop;Ensure;Experimental Designs;experimental study;Funding;Human Resources;Individual;Information Storage;investigator training;Laboratory Study;Maintenance;Malignant Neoplasms;Manuscripts;medical schools;member;Methodology;Methods;multidimensional data;Participant;Pilot Projects;posters;power analysis;Publications;Quality Control;Questionnaire Designs;relational database;Reporting;Research;Research Design;Research Personnel;Retrieval;Role;Sample Size;Services;Statistical Data Interpretation;symposium;Tennessee;The Vanderbilt-Ingram Cancer Center at the Vanderbilt University;Training;Universities;Work;Writing

PROJECT_TITLE: Core 2: Biostatistics Shared Resource Core


PI_NAMEs: PARK, BEN HO (contact)

PROJECT_TERMS: Advocacy;African American;African American population;Anatomy;animal tissue;anti-cancer research;Antigens;Awareness;Basic Science;Bioinformatics Shared Resource;Biological Markers;Biometry;Biopsy Specimen;Blood;Cancer Center;cancer health disparity;Cells;clinical diagnostics;Clinical Trials;Collaborations;Collection;Communities;Consultations;design;Development;DNA;Doctor of Philosophy;Drug or chemical Tissue Distribution;Education;Equity;Fee-for-Service Plans;Fluorescence;Formalin;Foundations;Future;General Hospitals;Genomics;Goals;Histologic;Histology;Histopathology;Human;human tissue;imaging capabilities;Immune;In Situ;Institution;liquid biopsy;Malignant Neoplasms;Medical Research;medical schools;Messenger RNA;microscopic imaging;Minority Groups;Molecular Biology;molecular diagnostics;Morphology;neoplastic;Normal tissue morphology;Operative Surgical Procedures;outreach;Paraffin Embedding;Pathology;Pilot Projects;Population;Population Research;Process;Proteomics;repository;Research;Research Personnel;Research Project Grants;Resource Sharing;Role;Services;Slide;Stains;Techniques;Technology;Tennessee;Time;Tissue Banks;tissue processing;Tissue Sample;Tissues;Translational Research;Universities;Work

PROJECT_TITLE: Core 3: Translational Pathology Shared Resource Core


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Rehabilitation;Women's Health Research

ORG_CITY: SAN FRANCISCO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Despite improved survival, the short and long-term complications of cancer and its treatment result in significant impairments in quality of life leading to an ongoing burden of cancer in these patients. We have developed and piloted integrative medicine approaches for cancer survivorship, which have shown promise of clinical benefit, and building on this work, we propose to optimize and test these approaches in a multi-site study. This work aims to address the significant burdens of cancer survivorship by improving the health and wellbeing of survivors.

PI_NAMEs: DHRUVA, ANAND  (contact)

PROGRAM_OFFICER_NAME: WEBER, WENDY J

PROJECT_TERMS: Academy;acceptability and feasibility;Acupressure;Address;Adherence;Aftercare;arm;Asia;Attention;Ayurvedic Medicine;Benchmarking;Breast Cancer Patient;Breast Cancer survivor;Cancer Burden;cancer care;cancer complication;cancer diagnosis;Cancer Intervention;Cancer Survivor;Cancer Survivorship;cancer therapy;Caring;Clinical;clinical care;Clinical Research;comparison intervention;Complement;curative treatments;Data;Detection;Development;Diagnosis;Diagnostic;Educational Intervention;efficacy study;efficacy trial;Enrollment;experience;Fatigue;Focus Groups;Funding;global health;Goals;Guidelines;Health;Health education;Healthcare;Impairment;implementation intervention;improved;improved outcome;individualized medicine;Integrative Medicine;Intervention;intervention delivery;intervention refinement;Left;Life Style;long-term sequelae;Low income;Malignant Breast Neoplasm;Malignant Neoplasms;Manuals;Measures;Medicine;Methodology;mind/body;Minor;Modeling;Modernization;Moods;Morbidity - disease rate;multimodality;National Center for Complementary and Integrative Health;nutrition;Participant;Patient Care;patient oriented;Patients;Personal Satisfaction;Persons;Pilot Projects;Population;Procedures;Process;psychosocial;Quality of life;Randomized;Randomized, Controlled Trials;recruit;Reporting;Research;Research Design;Sampling;Site;Sleep;Sleep disturbances;Survivors;survivorship;Symptoms;System;systems research;Testing;Therapeutic;therapy design;Time;treatment as usual;trial design;Underrepresented Populations;Universities;Work;Yoga

PROJECT_TITLE: Integrative Approaches for Cancer Survivorship: A Multi-Site Feasibility and Acceptability Study


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Genetics

ORG_CITY: MINNEAPOLIS

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative The assembly and movement of macromolecules in biological systems drive all aspects of health and disease at the cellular level. Study of the structure, assembly and function of the bacterial virus f29 DNA packaging motor serves as a model for understanding these fundamental biological principles and can inform us about similar processes in higher organisms. The DNA packaging process of f29 will also serve as a model for understanding similar events in the medically relevant herpesviruses and adenoviruses, thus providing targets for the development of new antiviral therapies.

PI_NAMEs: JARDINE, PAUL JAMES (contact);MORAIS, MARC

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TERMS: Address;Adenoviruses;Adopted;Animals;Anti-viral Agents;Anti-viral Therapy;ATP Hydrolysis;ATP phosphohydrolase;Bacillus subtilis;Bacteriophages;Binding;Biochemical;Biological;Biological Assay;Biological Models;biological systems;Biophysics;Capsid;Capsid Proteins;Cell Physiology;Chemicals;Communication;Complex;Computer Analysis;Coupled;Cryoelectron Microscopy;density;design;Development;Disease;DNA;DNA Packaging;Double Stranded DNA Virus;drug discovery;ds-DNA;Eukaryotic Cell;Event;flexibility;Generations;Genetic;Genome;Grant;Head;Health;Herpesviridae;Hydrolysis;image processing;In Vitro;insight;macromolecule;Mechanics;Medical;Modeling;Molecular;Molecular Conformation;molecular dynamics;Molecular Motors;molecular recognition;Motion;Motor;Movement;mutant;nano;Nature;Nucleic Acids;nucleoside triphosphatase;Nucleotides;operation;Organism;particle;Phase;Process;Protein Conformation;Proteins;rational design;Resolution;response;Sampling;single molecule;Structure;success;System;Testing;translocase;viral DNA;Viral Packaging;Visualization;Work

PROJECT_TITLE: The DNA Packaging Motor of Bacteriophage phi29

STUDY_SECTION: PCMB

STUDY_SECTION_NAME: Prokaryotic Cell and Molecular Biology Study Section[PCMB]


NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Social Determinants of Health

ORG_CITY: BIRMINGHAM

ORG_DEPT: NUTRITION

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE This is an innovative program to help junior scientists mainly from underrepresented groups to overcome barriers they face in career advancement. Program participants will have access to mentoring committee and have opportunities for 2-3 years to develop intra-personal, inter-personal and peer-oriented skills that will improve their chances for success as Principal Investigators in research careers.

PI_NAMEs: FERNANDEZ, JOSE R (contact);HILL, JAMES O

PROGRAM_OFFICER_NAME: SERRANO, KATRINA JANE

PROJECT_TERMS: Academia;Acceleration;Address;Alabama;Area;career;career development;Career Mobility;Chronic Disease;clinical center;Clinical Sciences;cohort;Country;Deep South;Development;Diabetes Mellitus;Education;Educational Curriculum;Educational workshop;Environment;experience;Face;Faculty;Funding;graduate student;Grant;Health;Health Disparities Research;health disparity;Health Occupations;Home;improved;Individual;Infrastructure;innovation;Institution;Journals;Leadership;Letters;Low income;Measures;Mentors;minority health disparity;Names;nutrition;Nutritional Science;Obesity;Participant;peer;Physical activity;physically handicapped;Polishes;Politics;Population;Positioning Attribute;Postdoctoral Fellow;pre-doctoral;Precision Health;precision nutrition;Principal Investigator;professor;programs;Race;Recommendation;Recording of previous events;recruit;Research;Research Personnel;Research Training;Resources;rural residence;Schools;Scientist;Senior Scientist;Series;skill acquisition;skills;success;Training;Training Programs;Translational Research;undergraduate student;Underrepresented Populations;United States National Institutes of Health;webinar;Wellness coaching

PROJECT_TITLE: Accelerating URiA Independent Research Potential in Nutrition Sciences


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Diabetes;Eye Disease and Disorders of Vision;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Prevention

ORG_CITY: PORTLAND

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE The current approach to prevent vision loss in diabetic retinopathy is inefficient due to the inherent imprecision of photograph-based screening in identifying eyes at short-term risk for vision-threatening complications. We propose an advanced optical coherence tomography angiography (OCTA) systemthat can reliably capture high- resolution, widefield angiographic and structural images with automated extraction of biomarkers that represent direct precursors of these complications, identifying patients that would benefit from treatment more precisely than clinical or photographic grading. This application includes foundational technological innovation, development of deep-learning aided biomarker detection algorithms, and prospective and cross-sectional validation of the technology in a real-life clinical setting with diabetic participants.

PI_NAMEs: HWANG, THOMAS ;JIA, YALI  (contact)

PROGRAM_OFFICER_NAME: GORDIYENKO, NATALIYA

PROJECT_TERMS: Address;Algorithms;analytical tool;Angiography;Area;arm;Attention;automated segmentation;Automation;Background Diabetic Retinopathy;Biological Markers;biomarker identification;Blindness;Blinking;candidate identification;Clinical;clinical examination;clinically relevant;clinically significant;Complications of Diabetes Mellitus;Cross-Sectional Studies;Custom;Data;deep learning;deep learning algorithm;density;Detection;detection sensitivity;Development;Devices;diabetic;Diabetic Retinopathy;Diagnosis;Early treatment;Ensure;Exhibits;Eye;feature extraction;Feedback;Fluorescein Angiography;Fundus;Fundus photography;Graph;high risk;Image;improved;instrument;Intuition;Lasers;learning network;Lesion;Life;Light;long short term memory;macular edema;Measures;Membrane;Methods;Microaneurysm;Modality;Modernization;Monitor;Morphologic artifacts;Motion;neovascular;neovascularization;novel;novel marker;novel strategies;Optical Coherence Tomography;Optics;Participant;Patients;Photography;Prediction of Response to Therapy;predictive marker;prevent;Probability;progression risk;proliferative diabetic retinopathy;prospective;Prospective Studies;prototype;Qualitative Evaluations;Resolution;Risk;risk stratification;sample fixation;Sampling;Scanning;Scheme;screening;Series;Severities;Signal Transduction;software development;Source;Speed;structural imaging;System;Techniques;technological innovation;Technology;technology validation;Testing;Time;Translations;treatment response;Vertebral column;Vision;Visual impairment

PROJECT_TITLE: OCTA Precursors of Vision-Threatening Complications of Diabetic Retinopathy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-NV-P(81)S]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Genetics;Neurosciences;Rare Diseases

ORG_DEPT: NEUROSURGERY

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: NARRATIVE Glioblastoma (GBM) is highly lethal, and a major contributing factor is the infiltrative tumor margin with a tumor- supportive niche for GBM invasion and relapse after therapy. This proposal aims to map the immune contexture, particularly microglia (MG), at GBM margins in order to delineate signaling networks and tumor-promoting factors (gliomagens) derived from margin-MG. Our study will advance basic understanding of tumor-host interactions at GBM margins, and provide proof-of-principle that targeting key signaling pathways with different mechanisms of action in tumor-associated microglia can help slow down GBM invasion and recurrence.

PI_NAMEs: HAMBARDZUMYAN, DOLORES ;ZOU, HONGYAN JENNY (contact)

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: Address;Aftercare;Automobile Driving;axon guidance;Biological Assay;Bone Marrow;Brain;Cell Communication;Cells;chemoradiation;Clinical;Coculture Techniques;combinatorial;Complement;Data;driver mutation;efficacy evaluation;Excision;Flow Cytometry;Genetic;genetic makeup;genetic signature;Genetic Transcription;Genetically Engineered Mouse;Glioblastoma;Growth;host neoplasm interaction;Human;IL1R1 gene;Immune;In Vitro;Infiltration;Interleukin-1;Invaded;irradiation;Knowledge;Macrophage;Malignant neoplasm of brain;Maps;Marrow;Microglia;Modeling;Molecular;Motility;multiple omics;Mus;Myeloid Cells;Nature;neoplastic cell;new therapeutic target;novel therapeutics;Oncogenic;Operative Surgical Procedures;pharmacologic;Phenotype;Pilot Projects;Play;plexin;Population;Preparation;Proliferating;Property;receptor;Recurrence;Relapse;Research;Residual Neoplasm;Residual state;Resistance;Rest;Role;Signal Pathway;Signal Transduction;Slice;Stromal Cells;Surgically-Created Resection Cavity;synergism;T-Lymphocyte;temozolomide;Testing;Tissues;tool;transcriptomics;tumor;Tumor Cell Invasion;Tumor Expansion;tumor microenvironment;Tumor Promotion;tumorigenic;Validation;validation studies

PROJECT_TITLE: Mapping Immune Contexture and Crosstalk with Tumor Cells At GBM Margin

STUDY_SECTION: THI

STUDY_SECTION_NAME: Tumor Host Interactions Study Section[THI]


NIH_SPENDING_CATS: Adolescent Sexual Activity;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Drug Abuse (NIDA only);HIV/AIDS;Health Services;Infectious Diseases;Pediatric;Pediatric - AIDS;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: KAMPALA

ORG_COUNTRY: UGANDA

ORG_FIPS: UG

ORG_NAME: MU-JHU CARE

PHR: Project Narrative Several studies show that adolescents and young adults (AYA) have poor outcomes along the entire HIV prevention and care cascades compared to adults. We propose to evaluate novel evidence-based HIV prevention and care interventions (including CAB-LA) to determine implementation outcomes among AYA who are at particularly high risk for HIV acquisition and poor viral suppression in five geographically distinct research performance sites in Uganda. The results will provide important evidence to inform Uganda and other regional countries’ policy on integrated HIV prevention, care and treatment for AYA at high risk for HIV and STI in order to reach the UNAIDS 95-95-95 targets and HIV epidemic control.

PI_NAMEs: MUSOKE, PHILIPPA  (contact);SEMITALA, FRED C

PROGRAM_OFFICER_NAME: LEE, SONIA S

PROJECT_TERMS: Adherence;Adolescent;Adolescent and Young Adult;Adoption;Adult;Africa South of the Sahara;aged;AIDS prevention;Anti-Retroviral Agents;Area;Attitude;Awareness;care systems;Caring;Catchment Area;Clinic;clinical implementation;Clinical Trials;Collaborations;Communities;Consolidated Framework for Implementation Research;Continuity of Patient Care;Country;design;Development;Effectiveness;effectiveness evaluation;effectiveness outcome;effectiveness/implementation design;effectiveness/implementation hybrid;Enrollment;epidemic response;evidence base;Evidence based intervention;experience;Female Adolescents;Focus Groups;follow-up;Friends;Fright;Geography;Guidelines;Health;Health care facility;Health Personnel;high risk;high risk sexual behavior;high-risk adolescents;HIV;HIV risk;HIV Seronegativity;HIV Seropositivity;HIV/STD;implementation barriers;implementation evaluation;implementation framework;implementation outcomes;implementation science;improved;Incidence;Individual;informant;innovation;Institution;Intervention;Interview;Knowledge;Leadership;Life;Location;low and middle-income countries;Maintenance;Male Adolescents;member;Methods;Modeling;multi-component intervention;multidisciplinary;novel;Oral;Outcome;Participant;Patients;peer;performance site;pill;Policies;Policy Maker;Population;pre-exposure prophylaxis;prevention service;preventive intervention;primary outcome;programs;Prospective Studies;Provider;Randomized;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Readiness;recruit;Research;Research Personnel;Resources;Risk;routine care;Rural;screening;service delivery;Service delivery model;Services;Severities;sex;side effect;Site;social;social stigma;Solid;Study Subject;success;Testing;testing uptake;Translating;Translations;Treatment outcome;Trust;Uganda;uptake;Viral;vulnerable adolescent;Work;Youth

PROJECT_TITLE: Implementation Science to Understand and Design Stakeholder Informed Innovative Interventions to Improve Adolescent and Youth HIV Prevention and Care Continuums in Rural and Urban Uganda


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences

ORG_CITY: CHAPEL HILL

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: PROJECT NARRATIVE In our daily lives, we rely on our brains’ ability to recognize social stimuli as safe or threatening in order to approach or avoid them. Our research will reveal key components of the complex neurocircuitry that is necessary to regulate social arousal, ultimately leading to discoveries that define the relationship between arousal and behavior, as well as pinpoint circuit mechanisms that can be targeted to develop better treatments for those suffering from disorders defined by maladaptive social behaviors.

PI_NAMEs: RODRIGUEZ-ROMAGUERA, JOSE  (contact)

PROGRAM_OFFICER_NAME: BREEDEN, ANDREW LEE

PROJECT_TERMS: Address;Amygdaloid structure;Anatomy;Arousal;avoidance behavior;Behavior;Behavior Disorders;behavior influence;Behavioral;Behavioral Assay;behavioral response;Biological;Brain;Brain region;Calcium;Cells;Characteristics;Complex;Disease;Exhibits;experimental study;Exposure to;Fluorescent in Situ Hybridization;Food;Frequencies;Future;Generations;Genes;Genetic;Genetic Markers;Head;Heart;Human;Image;In Situ Hybridization;in vivo;Individual;Intervention;Knowledge;Maps;Medial;Mediating;motivated behavior;Motivation;Mus;neural circuit;neural correlate;neuroimaging;Neurons;neuropsychiatric disorder;neurotransmission;Odors;optogenetics;Partner in relationship;Pathway interactions;Patients;Personal Satisfaction;Physiological;Physiological Processes;Population;Preoptic Areas;prepronociceptin;prevent;Process;Pupil;Rabies;Research;Respiration;respiratory;response;Role;segregation;Series;sex;Sex Differences;sexual dimorphism;social;Social Anxiety Disorder;Social Behavior;social influence;Social Interaction;Stimulus;Structure of terminal stria nuclei of preoptic region;success;Techniques;Technology;Testing;Therapeutic;tool;two-photon;Viral

PROJECT_TITLE: Encoding social arousal within prepronociceptin circuits in the extended amygdala


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Depression;Mental Health;Mental Illness

ORG_NAME: VERY REAL HELP, LLC

PHR: PROJECT NARRATIVE Cognitive Behavioral Immersion™ (CBI), defined as the delivery of cognitive behavioral skills training groups by lay coaches in the metaverse, has the potential to provide effective, affordable, and scalable support to those with depression and anxiety. The proposed randomized control trial is designed to evaluate the efficacy of CBI accessed via VR headsets (CBI-VR) to a treatment-as-usual (TAU) control and a non-immersive CBI condition accessed via flat screens (CBI-flat screen). If proven to be efficacious, the CBI platform could be marketed as an accessible, affordable, and scalable mental health program with utility to help individuals experiencing depression and comorbid anxiety.

PI_NAMEs: ROBINSON, NOAH  (contact)

PROGRAM_OFFICER_NAME: HAIM, ADAM J

PROJECT_TERMS: Affect;Anxiety;Anxiety Disorders;anxiety symptoms;Behavioral;Businesses;Caring;Clinical;Cognitive;cognitive enhancement;Cognitive Therapy;commercialization;comorbidity;cost;Data;depressive symptoms;design;Development;Devices;Educational process of instructing;effective therapy;Effectiveness;efficacy evaluation;efficacy testing;Employee Assistance Program (Health Care);Environment;experience;functional outcomes;Hearing;Immersion;indexing;Individual;Internet;Intervention;Investigation;Marketing;Measures;Mediator;Mental Depression;Mental Health;Modality;Mood Disorders;Motivation;Names;novel;opioid use disorder;Outcome;peer;peer support;Persons;Phase;prognostic;programs;Provider;psychologic;psychosocial;Psychotherapy;Public Health;Randomized, Controlled Trials;recruit;Regulation;Research;response;scale up;skill acquisition;skills;skills training;social stigma;Substance Use Disorder;supportive environment;Symptoms;Technology;Television;Testing;Training;treatment as usual;uptake;virtual environment;virtual reality;virtual reality environment;virtual reality headset

PROJECT_TITLE: Cognitive Behavioral Immersion: A Randomized Control Trial of Peer-Based Coaching in the Metaverse


ADMINISTERING_IC: LM

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Data Science;Intellectual and Developmental Disabilities (IDD);Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Pediatric

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative Mental health accounts for a significant percentage of the global health burden and suffers from unscalable treatments that could be better delivered through mobile AI. Taking aim at the increasingly prevalent condition of pediatric autism, our project will result in a mobile game that delivers valuable treatments while growing unique training libraries for artificial intelligence that measure the phenotype as it changes.

PI_NAMEs: WALL, DENNIS PAUL (contact)

PROGRAM_OFFICER_NAME: FARRELL, CATHERINE MARY

PROJECT_TERMS: 8 year old;Accounting;Active Learning;Adaptive Behaviors;Address;Age;annotation  system;Artificial Intelligence;artificial intelligence model;autism spectrum disorder;autism symptoms;autistic children;Awareness;Behavior;behavior prediction;Behavior Therapy;burden of illness;Caring;catalyst;Cellular Phone;Child;Child Development;Childhood;Classification;Clinical;Clip;Complement;Complex;Computer Vision Systems;Crowding;crowdsourcing;Data;Data Collection;data library;Data Science;Data Set;data sharing;Databases;deep learning;deep learning model;deep neural network;design;Development;digital health;digital treatment;disability;Disease;Emotional;Emotions;Ensure;Entropy;Eye;Family;feasibility testing;feature detection;feature extraction;feature selection;Feedback;Foundations;Frequencies;gaze;Gestures;global health;Grant;Growth;Hand;Health;Healthcare;Human;Image;Individual;insight;interest;Intervention;invention;iterative design;Label;Language;Learning;learning strategy;Libraries;Liquid substance;Manuals;Measures;Medicine;Mental Health;Metadata;mobile application;model design;model development;Modeling;Names;neural network;Neural Network Simulation;neuropsychiatric disorder;novel;Parents;patient engagement;Pattern;Performance;personalized intervention;personalized predictions;Phenotype;Play;Prevalence;privacy preservation;Probability;Process;prototype;Risk;Running;Secure;sensor;showing emotion;simulation;social;Social Behavior;social communication;social engagement;Socialization;success;Symptoms;System;Systems Development;targeted treatment;Techniques;Testing;therapy design;Time;tool;Training;training data;treatment effect;trustworthiness;uptake;user-friendly;Waiting Lists;Work

PROJECT_TITLE: An active learning framework for adaptive autism healthcare

STUDY_SECTION: BDMA

STUDY_SECTION_NAME: Biodata Management and Analysis Study Section[BDMA]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Burden of Illness;Dementia;Disability Research;Eye Disease and Disorders of Vision;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Public Health Relevance Statement PROJECT NARRATIVE The proposed research is relevant to public health because it focuses on providing up-to-date estimates of the number of older adults in the U.S. with vision impairment and blindness, as well as key insights on the associations between risk factors, vision impairment and blindness, and late-life outcomes like dementia, long-term care placement, and mortality. This study will use newly collected vision data from the NIH-funded National Health and Aging Trends Study (NHATS) to conduct longitudinal analyses that are nationally representative of older adults aged ≥65 in the U.S. Thus, the proposed research is relevant to the NIH’s mission to enhance health and reduce illness.

PI_NAMEs: EHRLICH, JOSHUA ROBERT (contact)

PROGRAM_OFFICER_NAME: LE, JIMMY TOAN

PROJECT_TERMS: Address;Admission activity;Adopted;Adult;adverse outcome;Affect;age group;age stratification;Aged, 80 and over;Aging;beneficiary;Black Populations;blind;Blindness;built environment;Collaborations;comorbidity;Complex;contextual factors;Contrast Sensitivity;Data;data archive;Dementia;demographics;Development;Diagnosis;disability;dissemination strategy;Economics;epidemiologic data;Epidemiology;ethnic minority;Ethnic Origin;Ethnic Population;experience;Eye;Eye diseases;Funding;Growth;Health;health care availability;Health care facility;health disparity;health equity;Healthcare Systems;Hispanic Populations;human old age (65+);Impairment;Incidence;Individual;insight;interest;late life;Link;Long-Term Care;longitudinal analysis;Measurement;Measures;Mediating;Mediation;Medicare;Medicare claim;Mission;Modeling;mortality;National Eye Institute;Neighborhoods;novel;older adult;Older Population;Outcome;Personal Satisfaction;Persons;Policies;Population;population based;Prevalence;prospective;Protocols documentation;Public Health;Public Policy;Race;racial minority;racial minority population;Reporting;Research;Research Personnel;Research Support;Risk Factors;Sample Size;Sampling;sex;social health determinants;social media;socioeconomics;Strategic Planning;Surveys;symposium;System;Testing;Time;trend;United States National Institutes of Health;Validation;Vision;Vision Tests;Visual;Visual Acuity;Visual impairment;Work

PROJECT_TITLE: Vision Impairment in the National Health and Aging Trends Study

STUDY_SECTION: AIMR

STUDY_SECTION_NAME:
Aging, Injury, Musculoskeletal, and Rheumatologic Disorders Study
Section[AIMR]


NIH_SPENDING_CATS: Aging;Clinical Research;Data Science;Health Services;Networking and Information Technology R&D (NITRD);Patient Safety

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: PROJECT NARRATIVE We will partner with two patient safety studies of older hospitalized adults to design, develop, implement, and evaluate methods for empowering patients to locate, collect, and share their electronic health records for research. This work will enhance our existing digital infrastructure by leveraging two open-source projects that have developed core infrastructural building blocks. Our results will provide critical lessons that demonstrate the value of using interoperable standards for empowering patients to share their data for research, and how the combined data can create new knowledge about patient safety risks in older adults who are hospitalized.

PI_NAMEs: DALAL, ANUJ K (contact);RUDIN, ROBERT SAMUEL

PROGRAM_OFFICER_NAME: SALIVE, MARCEL

PROJECT_TERMS: Acute;acute care;Address;Adoption;Adult;Adverse event;adverse event risk;Agreement;All of Us Research Program;analytical method;care coordination;care episode;care fragmentation;Caregivers;Caring;Clinical;clinical care;Clinical Research;Collection;Computer software;Consent;Data;Data Aggregation;Data Analyses;data exchange;data harmonization;data integration;data interoperability;data modeling;data sharing;data standards;design;Detection;digital;Disparate;Elderly;electronic data;electronic health data;Electronic Health Record;empowerment;Enrollment;Ensure;Exposure to;Fast Healthcare Interoperability Resources;Funding;health care service;Health Personnel;Health system;Hospitalization;Hospitals;improved;Individual;information model;Information Systems;Infrastructure;Institution;interoperability;Knowledge;Leadership;Measures;Mediation;Methods;Modeling;multiple chronic conditions;Natural Language Processing;novel;older adult;older patient;open source;Participant;participant enrollment;Patient Recruitments;patient safety;Patient Self-Report;Patients;Play;Population;Process;prospective;Provider;Public Policy;Research;research study;Risk;Risk Factors;Role;Safety;safety assessment;safety outcomes;safety study;Science;secondary analysis;Secure;Services;Site;Source Code;Structure;Syndrome;Technology;Text;timeline;United States Agency for Healthcare Research and Quality;user centered design;web app;Woman;Work

PROJECT_TITLE: Demonstrating the potential for electronic health record interoperability to improve patient safety research of older adults over the acute episode of care.


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Depression;Health Services;Major Depressive Disorder;Mental Health;Mental Illness;Neurodegenerative;Neurosciences;Serious Mental Illness

ORG_CITY: FARMINGTON

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT

ORG_STATE: CT

PHR: Project Narrative Electroconvulsive therapy (ECT) may be an effective treatment modality for severe neuropsychiatric symptoms (NPS) of Alzheimer’s disease and related dementias (ADRD). Using a nationwide, longitudinal cohort design, this study aims to examine longitudinal associations of ECT with NPS and other key clinical outcomes in adults with ADRD. Our findings will inform more effective clinical guidance on ECT use in older adults with ADRD.

PI_NAMEs: RHEE, TAEHO GREGORY (contact)

PROGRAM_OFFICER_NAME: MCLINDEN, KRISTINA

PROJECT_TERMS: Address;Admission activity;Adult;Advisory Committees;Affect;Aggressive behavior;aging related disease;Agitation;Alzheimer's disease related dementia;American Psychiatric Association;anti-depressive agents;Antipsychotic Agents;Behavior Therapy;beneficiary;Bipolar Disorder;brain cell;case finding;Case Series;Case Study;Catatonia;Cessation of life;Clinic;Clinical;Clinical Trials;Cohort Studies;Data;Data Analyses;Death Rate;Dementia;Depressed mood;depressed patient;design;Development;effective therapy;Effectiveness;Elderly;Electroconvulsive Therapy;Epidemiology;Etiology;Fire - disasters;follow-up;frailty;functional decline;functional disability;Future;General Anesthesia;Guidelines;Health;Health Services Research;Home;Hospitals;improved;Incidence;indexing;Individual;innovation;insight;Intervention;Knowledge;Life;Link;longitudinal analysis;Longitudinal cohort;Longitudinal cohort study;Longitudinal Studies;Maintenance;Medicare;Medicare claim;Mental Depression;Mental disorders;Methods;mixed dementia;Modality;Modeling;Morbidity - disease rate;mortality;multiple data sources;Neurodegenerative Disorders;neuropsychiatric symptom;Nursing Homes;older adult;older patient;Outcome;Patient Preferences;Pattern;pharmacologic;Population;population based;Prevalence;psychotic depression;Public Health;Recommendation;Resources;Risk;Safety;Scalp structure;Schizoaffective Disorders;Seizures;sociodemographics;Stimulus;Surveys;Symptoms;Syndrome;Techniques;Testing;Therapeutic;Time;treatment response;treatment-resistant depression;United States Centers for Medicare and Medicaid Services

PROJECT_TITLE: Longitudinal Associations of Electroconvulsive Therapy with Neuropsychiatric Symptoms, Geriatric Syndromes, and Nursing Home Admission and Mortality Rates among Adults with Dementia


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Cannabidiol Research;Cannabinoid Research;Chronic Obstructive Pulmonary Disease;Drug Abuse (NIDA only);Genetics;Infectious Diseases;Lung;Natural Products;Prevention;Substance Misuse;Therapeutic Cannabinoid Research;Tobacco

ORG_CITY: Columbus

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE While cigarette smoking has been declining, marijuana smoking and vaping are steadily on the rise, although their health risks are still poorly understood. Our research project will identify the effects of marijuana and vaping on the ability of the lung to defend against pathogens. Upon completion of this project, we will have a better understanding of the long lasting effects of THC, marijuana, and vaping on the health risks associated with this behavior.

PI_NAMEs: CORMET-BOYAKA, ESTELLE A (contact)

PROGRAM_OFFICER_NAME: MANDLER, RAUL N

PROJECT_TERMS: Acute;Air;airway epithelium;anti-microbial drug;antimicrobial;Apical;Bacteria;Bacterial Infections;Behavior;bronchial epithelium;Cannabidiol;cannabinoid receptor;Cannabinoids;Cell Proliferation;Cells;Chronic;Chronic Bronchitis;Cigarette;cigarette smoking;Cilia;CNR1 gene;CNR2 gene;Coughing;Cystic Fibrosis;Cystic Fibrosis Transmembrane Conductance Regulator;Data;Devices;differential expression;Electronic cigarette;Environmental Pollutants;epigenomics;Epithelial Cells;Excision;Exposure to;exposure to cigarette smoke;Frequencies;functional genomics;Gene Expression;Genes;Goals;Goblet Cells;Health;Homeostasis;Host Defense;Human;Hydration status;Hyperplasia;Impairment;In Vitro;in vivo;Infection;Infection prevention;Inhalation;Ion Channel;Legal;Liquid substance;Long-Term Effects;Lung;lung development;Lung Diseases;Marijuana;marijuana smoke;Marijuana Smoking;marijuana use;marijuana vaping;Measures;Medical Marijuana;Metaplasia;methicillin resistant Staphylococcus aureus;Modeling;Molecular;Molecular Target;Mucociliary Clearance;Mucous body substance;National Institute of Drug Abuse;Nature;Obstructive Lung Diseases;Outcome;particle;pathogen;pathogenic microbe;Pathway Analysis;Pathway interactions;Patients;Peptides;Persons;Predisposition;Preparation;Primary Ciliary Dyskinesias;Production;Proteins;Proteomics;Psychotropic Drugs;Recovery;Recreation;Research;Research Project Grants;response;Rheology;Risk;RNA;Role;Secretory Cell;Smoker;Smoking;Sputum;Staphylococcus aureus infection;Substance Use Disorder;System;Teenagers;Testing;Tetrahydrocannabinol;THC exposure;Tobacco smoking behavior;transcriptome sequencing;transcriptomics;treatment effect;United States;United States National Institutes of Health;US State;vaping;vaping THC;Virus;Virus Diseases

PROJECT_TITLE: Alteration of bronchial epithelium host defenses by marijuana and vaping preparations

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-RCCS-B(03)]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Prevention;Sexually Transmitted Infections;Social Determinants of Health;Substance Misuse;Telehealth

ORG_DEPT: PSYCHOLOGY

ORG_NAME: HUNTER COLLEGE

PHR: Project Narrative – Public Health Significance The development of effective drug use interventions for sexual minority men (SMM) in relationships is a public health priority. Drug use is a well-established correlate of sexual HIV transmission risk behavior for SMM in relationships and 35-68% of new HIV infections among SMM are transmitted between main partners. To date, applications of Motivational Interviewing with couples were relatively rare and produced mixed results. Building on our successful pilot, we propose an efficacy trial of the Couples Health Project (CHP) – a 3-session, couples MI protocol – involving 180 couples living in the US. Aligned with the recent expansion of telehealth service delivery, the study will utilize remote assessments and telehealth intervention delivery based at 3-sites.

PI_NAMEs: STARKS, TYREL J (contact)

PROGRAM_OFFICER_NAME: JENKINS, RICHARD A

PROJECT_TERMS: Address;Adherence;Age;aged;Agreement;AIDS prevention;Attention;Behavior Therapy;binge drinking;Biological Assay;Biological Markers;Bisexual;Chlamydia;Chlamydia Infections;Client;Cocaine;Communication;condomless anal sex;Conflict (Psychology);Counseling;Couples;COVID-19 pandemic;Data;Development;Dose;Drug Addiction;Drug usage;ecstasy;efficacy evaluation;efficacy testing;efficacy trial;Emotional;Event;evidence base;Feedback;follow up assessment;Frequencies;Funding;future implementation;Gays;Geography;Goals;Gonorrhea;Health;Health behavior;health care delivery;Health Insurance Portability and Accountability Act;Health Professional;Heterosexuals;high risk;HIV;HIV Infections;HIV risk;HIV Seronegativity;Human immunodeficiency virus test;illicit drug use;implementation research;Incidence;Individual;Infection;Infrastructure;Injections;Intervention;intervention delivery;Investments;Ketamine;male couples;Mediator;Medical;men;men who have sex with men;Mental Health;Methamphetamine;motivational enhancement therapy;multi-site trial;New York City;novel;Outcome;Participant;Partner in relationship;Patient Self-Report;Pharmaceutical Preparations;post intervention;pre-exposure prophylaxis;Professional counselor;Protocols documentation;psychoeducation;Public Health;public health priorities;Randomized;Randomized, Controlled Trials;recruit;Rectum;remote assessment;Reporting;Research;research facility;Risk Behaviors;Risk Reduction;satisfaction;Severities;Sex Behavior;Sexual Health;sexual HIV transmission;sexual minority men;Sexual Partners;sexual risk behavior;sexual risk taking;Sexually Transmitted Diseases;Site;skills;standard of care;substance use;substance use treatment;success;Syphilis;telehealth;Testing;theories;therapy development;Time;transmission process;trial enrollment;United States;uptake;Urethra;Urine;Work

PROJECT_TITLE: Couples Motivational Interviewing to reduce drug use and HIV risk in vulnerable male couples

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Microbiome;Neurodegenerative;Neurosciences;Nutrition

ORG_CITY: WORCESTER

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: Project Narrative As our population ages, the incidence of Alzheimer's disease increases adding economic and social stress. Here, we seek to dissect how consumption of a sugar-loaded diet alters the microbiome and contributes to the onset and severity of Alzheimer's disease with a long-term goal of using diet as an intervention for Alzheimer's disease.

PI_NAMEs: TISSENBAUM, HEIDI A (contact)

PROGRAM_OFFICER_NAME: HAAKENSON, CHELSEA MARIE

PROJECT_TERMS: abeta accumulation;Address;Advanced Glycosylation End Products;Affect;Age;age related;Aging;Alzheimer's Disease;Alzheimer's disease patient;American;American diet;Amino Acids;Amyloid beta-42;Amyloid beta-Protein;Amyloid beta-Protein Precursor;Animal Diseases;Animals;Bacteria;Brain;Buffers;Caenorhabditis elegans;Circulation;constitutive expression;Consumption;Data;Diabetes Mellitus;Diet;dietary;Dietary Sugars;Economics;Environment;Escherichia coli;Food;gastrointestinal system;Genes;Genetic;Glucose;glycation;Goals;Grant;gut microbiota;Health;Health Care Costs;healthspan;Human;Immune;Immune signaling;Incidence;inducible gene expression;Inflammation;insight;Intervention;life span;Link;Lipids;Metabolism;Microbe;microbiome;microbiome alteration;microbiota;Movement;Muscle;mutant;Neurons;Orthologous Gene;Oxidative Stress;Paralysed;Pathogenicity;Pathway interactions;Peptides;Persons;Population;presenilin;Process;promoter;Proteins;Publishing;Regulation;Series;Severities;Signal Pathway;Silver;social stress;Source;Stress;stress management;Structure;sugar;System;Testing;Tissues;tool;Transgenic Animals;Transgenic Organisms;Tsunami

PROJECT_TITLE: Dissecting connections between diet, the microbiome and Alzheimers disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AN-Z(55)]


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: Canton

ORG_NAME: HARVARD PILGRIM HEALTH CARE, INC.

PHR: PROJECT NARRATIVE Hospitals, clinicians, policy makers, and researchers are blind to the full breadth of serious healthcare- associated infections (HAIs) owing to the current focus by the Centers for Medicare & Medicaid Services on just a limited set of reportable HAIs as well as reliance on traditional manual surveillance methods that are labor-intensive and vary widely in their sensitivity, accuracy, and reproducibility. This proposal will build on the recent development of a validated electronic surveillance definition for hospital-onset sepsis by characterizing its incidence, outcomes, and hospital-level variation compared to current reportable HAIs across 145 diverse hospitals; elucidating its impact on long-term outcomes; and developing electronic algorithms to identify the specific infections leading to sepsis. This work will advance the science of automated surveillance for the most serious nosocomial infections, including many missed by current reportable HAIs, which in turn will help identify new targets for prevention and quality improvement and thereby catalyze better outcomes for hospitalized patients.

PI_NAMEs: RHEE, CHANU  (contact)

PROGRAM_OFFICER_NAME: MILLER, MELISSA

PROJECT_TITLE: Electronic Surveillance for Hospital-Onset Sepsis to Expand Detection of Serious Healthcare-Associated Infections

STUDY_SECTION: HSQR

STUDY_SECTION_NAME: Healthcare Patient Safety and Quality Improvement Research[HSQR]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Mental Health;Mental Illness;Neurosciences

ORG_CITY: BERKELEY

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: This project focuses on understanding how the orbitofrontal cortex uses hippocampal cognitive maps to implement rapid, flexible, decision-making. Dysfunction of both these brain areas has been implicated in a wide variety of neuropsychiatric disorders, including schizophrenia, depression, anxiety, and post-traumatic stress disorder. Understanding the contribution of this pathway could lead to an important target for future therapeutic interventions.

PI_NAMEs: WALLIS, JONI D (contact)

PROGRAM_OFFICER_NAME: ROSSI, ANDREW F

PROJECT_TERMS: Affect;Algorithms;Anxiety;Area;awake;Behavioral;Brain;Cells;Code;Cognitive;Communication;Complex;Compulsive Behavior;Computer Models;Decision Making;Devices;Disease;Electric Stimulation;Endowment;Environment;environmental change;falls;flexibility;frontal lobe;Functional disorder;Future;Goals;Grant;Graph;Hippocampus;Impairment;knowledge graph;Learning;learning algorithm;Location;Major Depressive Disorder;maladaptive behavior;Maps;Mental Depression;microstimulation;Modeling;Monkeys;neural;neural circuit;neuromechanism;Neurons;neurophysiology;neuropsychiatric disorder;novel;Pathway interactions;Patients;Pharmaceutical Preparations;Play;Post-Traumatic Stress Disorders;Predictive Value;Prevalence;Probability;Process;Property;Psychiatry;Research;response;Rewards;Role;Schizophrenia;Severities;spatiotemporal;Specific qualifier value;Symptoms;Testing;Therapeutic;Therapeutic Intervention;Theta Rhythm;Update

PROJECT_TITLE: Neuronal mechanisms of model-based learning

STUDY_SECTION: LMDN

STUDY_SECTION_NAME: Learning, Memory and Decision Neuroscience Study Section[LMDN]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Opioid Misuse and Addiction;Opioids;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse;Telehealth

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

PHR: Project Narrative In 2020, over 85,000 people died from drug overdoses in the US with mortality rates skyrocketing for Black and Latinx people by 140% and 118% respectively, however the national media has focused on deaths among White people, with minimal attention given to the disparate morbidity and mortality related to opioid use disorder (OUD) and alcohol use disorder (AUD) among Black and Latinx people. In 2017, to tackle the unique challenges of decreased treatment initiation, engagement, and adherence to addiction treatment for Black and Latinx people with SUDs, we developed Imani (meaning Faith in Swahili) Breakthrough, a faith-based, person- centered, culturally-informed harm reduction recovery program, through a community based participatory process (in collaboration with key stakeholders), that takes place in churches. The main goal of this current study is to increase the methodological rigor of Imani by conducting a randomized controlled trial (RCT) to examine whether adding a Church-based Telehealth MAT option to Imani (Imani + CTM) will improve outcomes for Black and Latinx people with AUD or OUD compared to Imani + traditional MAT Referral and Linkage (Imani + MAT R&L) in the community.

PI_NAMEs: BELLAMY, CHYRELL DENISE (contact);JORDAN, AYANA

PROGRAM_OFFICER_NAME: ZUR, JULIA BETH

PROJECT_TERMS: addiction;addiction treatment referral;Address;Adherence;alcohol involvement;alcohol use disorder;alcoholism therapy;Attention;Black Populations;Black race;burden of illness;Cessation of life;Church;Collaborations;Color;Communities;community based participatory approach;community based participatory research;COVID-19;COVID-19 pandemic;Death Rate;Dimensions;disparities in morbidity;disparity gap;Education;effective intervention;Elements;Enrollment;Environment;Ethnic Population;experience;Faith;FDA approved;Fentanyl;Foundations;Goals;Harm Reduction;health care disparity;health disparity;Healthcare Systems;improved;improved outcome;Individual;innovation;interest;Intervention;Latinx;Latinx population;Learning;Link;Lived experience;manufacture;Mediator;Methodology;Methods;minority communities;Minority Groups;Morbidity - disease rate;mortality;Opioid;opioid use disorder;Outcome;Overdose;Participant;person centered;Persons;Pharmaceutical Preparations;Pharmacotherapy;Policy Maker;policy recommendation;Population Intervention;Prevalence;Process;programs;Provider;Public Health;racial population;Randomized, Controlled Trials;Recovery;Research;Services;social health determinants;Spirituality;Structural Racism;substance use;Substance Use Disorder;Technology;telehealth;Time;Training;Underrepresented Minority;United States Substance Abuse and Mental Health Services Administration;uptake;Vulnerable Populations

PROJECT_TITLE: Culturally-responsive community-driven substance use recovery for Black and Latinx populations


NIH_SPENDING_CATS: Aging;Chronic Pain;Interstitial Cystitis;Neurosciences;Pain Research;Urologic Diseases

ORG_DEPT: ANESTHESIOLOGY

PHR: Public Health Relevance. There is a lack of knowledge related to how urinary bladder sensation changes with aging despite a known increase in bladder problems in the elderly. The present study will characterize bladder sensation using reflex and neuronal measures in rats and longitudinally determine how sensation changes with time in females as part of normal aging processes (e.g., menopause equivalent) and in response to a pathological alteration of sensation induced by developmental events experienced as a neonate. This increase in knowledge will allow for improved treatment of bladder pain in adults as it will suggest novel therapeutic strategies.

PI_NAMEs: DEBERRY, JENNIFER J;NESS, TIMOTHY J (contact)

PROGRAM_OFFICER_NAME: MULLINS, CHRISTOPHER V

PROJECT_TERMS: Acute Pain;acute stress;Adult;Affect;Age;age effect;aged;Aging;aging process;antagonist;Basic Science;Biological Models;Bladder;bladder pain;Bladder Tissue;chronic pain;Clinical;clinically relevant;conditioned pain modulation;Corticotropin-Releasing Hormone Receptors;critical period;Data;Development;Diagnosis;Elderly;Elements;endogenous opioids;Esthesia;Event;experience;experimental study;Failure;Female;Histology;Human;Hypersensitivity;improved;Incidence;Inflammation;insight;Interstitial Cystitis;Knowledge;Life;Measures;Menopause;Modeling;Naloxone;Neonatal;neonate;nerve injury;Neurons;neurophysiology;Nociception;normal aging;novel;novel therapeutic intervention;novel therapeutics;Opioid;Pathologic;Pathway interactions;Phenotype;Prevalence;Productivity;public health relevance;Rattus;Reflex action;Research;Research Project Grants;Resistance;response;Rodent;Rodent Model;Role;Sensory;Spinal;System;Testing;Therapeutic;Time;Translations;Trigeminal nerve structure;young adult

PROJECT_TITLE: Quantitative Studies in Urinary Bladder Sensation

STUDY_SECTION: KUFD

STUDY_SECTION_NAME: Kidney and Urological Systems Function and Dysfunction Study Section[KUFD]


PHR: NARRATIVE The COVID-19 pandemic stresses the deep interconnection between patient and worker safety, yet most hospitals had separate initiatives for either patient or worker safety. One promising approach to respond to this need is through a program that integrates stakeholders, including influential front-line workers, to address overlapping risk factors for patient falls and patient-assist injuries. Building on a successful pilot program focused on safe patient handling and mobility (SPHM), the objective of this proposal is to conduct a cluster randomized controlled trial in rural hospitals in Oregon to evaluate the effectiveness and process of an integrated SPHM program titled Safety Integration Stakeholders (SAINTS).

PI_NAMEs: HURTADO, DAVID ALEJANDRO (contact)

PROGRAM_OFFICER_NAME: GRIPIOTIS, EROFILE

PROJECT_TITLE: The Safety Integration Stakeholders (SAINTS) program to integrate worker and patient safety in Oregon rural hospitals


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Heart Disease;Hypertension;Prevention;Social Determinants of Health

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Narrative In Chicago, health status indicators show worsening disparities between black and white residents, with the highest rates of hypertension, heart disease, and stroke clustering in the predominantly black South and West Sides. Kaiser Permanente demonstrated that a bundle of evidence-based interventions implemented within a large, integrated health system significantly increased blood pressure control, however, it is unclear whether a health system centered intervention can be adapted to other settings, particularly under-resourced urban communities. Thus, the focus of our proposed project is on the strategies used to support adoption, implementation with fidelity, and sustainability of the Kaiser bundle within a Chicago community with a high burden of hypertension.

PI_NAMEs: DAVIS, PARIS ;KHO, ABEL N. (contact);SMITH, JUSTIN D

PROGRAM_OFFICER_NAME: KHAN, SHAHNAZ

PROJECT_TERMS: Adoption;Adult;Affect;American;Area;Blood Pressure;blood pressure control;blood pressure elevation;California;Cardiovascular Diseases;cardiovascular risk factor;Cessation of life;Chicago;Church;Clinic;Clinical;Clinics and Hospitals;Combined Modality Therapy;Communities;community engagement;Community Health;Community Health Aides;community intervention;community involvement;community setting;community-centered;data platform;design;Disparity;Dissemination and Implementation;economic indicator;Education;Effectiveness;effectiveness/implementation design;Evaluation;evidence base;evidence based guidelines;Evidence based intervention;experience;Exploration, Preparation, Implementation, and Sustainment;Faith;Faith-based organization;Feedback;follow-up;Goals;Health;Health Information System;Health Status Indicators;Health system;Heart Diseases;Hybrids;Hypertension;hypertension control;Impact evaluation;implementation outcomes;implementation strategy;improved;Individual;inner city;Integrated Health Care Systems;Intervention;Logistic Regressions;Maps;Measurement;Medical;medically underserved;Methods;Mind;Minority Groups;Modeling;mortality disparity;Outcome;Outcome Study;Participant;Patient risk;Patients;Phase;pill;Pilot Projects;preference;primary outcome;Probability;Process;Public Health;Publications;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Reduce health disparities;Registries;Research;Resources;Risk Factors;safety net;Scientist;Side;socioeconomics;Stroke;System;Testing;Treatment Protocols;underserved community;United States;urban area;Urban Community;Work

PROJECT_TITLE: Community Intervention to Reduce CardiovascuLar Disease in Chicago (CIRCL-Chicago)


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Bioengineering;Chronic Liver Disease and Cirrhosis;Clinical Research;Cost Effectiveness Research;Data Science;Digestive Diseases;Dissemination and Implementation Research;Drug Abuse (NIDA only);Emergency Care;HIV/AIDS;Health Services;Hepatitis;Hepatitis - C;Infectious Diseases;Liver Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Substance Misuse

ORG_CITY: GAINESVILLE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE Identifying individuals with hepatitis C virus (HCV) infection provides a critical opportunity to connect them with care, including treatment with highly effective direct-acting antivirals that can cure HCV and thus may slow or reverse disease progression and reduce HCV transmission, and to identify individuals who, through shared routes of transmission, may be co-infected with human immunodeficiency virus (HIV). Using machine-learning algorithms, we propose to first develop prediction models to identify patients at risk of HCV and then to translate the best prediction algorithm into a best practice advisory platform integrated into the electronic health records system. This innovative and integrated platform will better guide clinical providers and health care systems, improve HCV and HIV screening in emergency department settings, and help link patients with care.

PI_NAMEs: PARK, HAESUK  (contact)

PROGRAM_OFFICER_NAME: FITZ-RANDOLPH, MARCY ESTHER

PROJECT_TERMS: Accident and Emergency department;Adult;Algorithms;Anti-viral Agents;Anti-viral Therapy;Artificial Intelligence;Caring;Chronic Hepatitis C;Clinical;Clinical Data;clinical practice;Clinical Research;co-infection;Continuity of Patient Care;cost;cost effective;cost effectiveness;Data;design;Development;Diagnosis;Diagnostic;Disease Progression;economic outcome;Educational workshop;Effectiveness;Electronic Health Record;electronic health record system;Emergency department screening;Exploration, Preparation, Implementation, and Sustainment;Feedback;Florida;Funding;Goals;HCV screening;Health;Healthcare Systems;Hepatitis;Hepatitis C;Hepatitis C Therapy;Hepatitis C Transmission;Hepatitis C virus;high risk;high risk behavior;HIV;Homelessness;implementation framework;implementation outcomes;improved;Individual;Infection;injection drug use;innovation;Intervention;Interview;Link;Liver;Machine Learning;machine learning algorithm;machine learning prediction algorithm;Methods;Morbidity - disease rate;mortality;National Institute of Drug Abuse;Natural Language Processing;Notification;Nurses;opioid epidemic;Patient Self-Report;Patients;Performance;Persons;Physicians;Play;Positioning Attribute;prediction algorithm;predictive modeling;Proctor framework;prototype;Provider;Public Health;Questionnaires;Recommendation;recurrent neural network;Research;Risk;Risk Assessment;Risk Behaviors;Risk Factors;risk stratification;Role;Route;screening;Screening procedure;screening program;Social Behavior;structured data;Substance Use Disorder;Testing;Time;tool;Translating;transmission process;United States;Universities;usability;Venous blood sampling;viral transmission;virus testing;Visit;Work

PROJECT_TITLE: Assessing performance of a Hepatitis C Emergency Department (HepC-END) Screening Tool

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Climate-Related Exposures and Conditions;Clinical Research;Clinical Trials and Supportive Activities;Cost Effectiveness Research;Infectious Diseases;Malaria;Pediatric;Prevention;Rare Diseases;Social Determinants of Health;Vector-Borne Diseases

PHR: PROJECT NARRATIVE The impact of global climate change, including the increased frequency of weather extremes such as flooding, on the incidence of malaria and other vector-borne diseases is an issue of substantial public health importance. Thus, there is an urgent need not only to elucidate the changes in the ecological, biological, and social factors that impact malaria transmission in the post-flood environment, but also to develop effective mitigation and control strategies. Therefore, the scientific aim of this proposal is to evaluate the effectiveness of a targeted, time-limited malaria chemoprevention intervention with and without larval source management (LSM) to reduce excess malaria burden in a perennial, high-transmission setting following severe flooding.

PI_NAMEs: BOYCE, ROSS MATHEW (contact)

PROGRAM_OFFICER_NAME: MCGUGAN, GLEN C

PROJECT_TERMS: 12 year old;Acute;Address;Adolescent;Adult;Affect;Anopheles Genus;Anxiety;Area;arm;Artemisinins;Automobile Driving;Binding;Biological Factors;Blood;burden of illness;Chemoprevention;Child;climate change;climate impact;Cluster randomized trial;Collaborations;Communities;comparison control;Complex;cost effectiveness;Cost Effectiveness Analysis;Culicidae;Data;Dedications;Development;Droughts;Economic Burden;economic impact;economic outcome;Economics;effectiveness evaluation;Environment;Epidemic;Evolution;Expenditure;extreme weather;Falciparum Malaria;feeding;Feeding behaviors;Floods;Frequencies;Goals;Habitats;Health;Health care facility;health economics;Healthcare;Hospitalization;Household;Human;Incidence;Income;Intervention;Knowledge;Laboratories;Malaria;malaria transmission;Mental Health;National Institute of Allergy and Infectious Disease;new epidemic;Parasites;Personal Satisfaction;Phase;Plasmodium falciparum;Population;post intervention;prevent;preventive intervention;primary outcome;Public Health;relative cost;Research;Resistance;Rural;Sampling;Schools;Scientist;Seasons;Sentinel;Site;social factors;Social Impacts;Social outcome;socioeconomics;Source;Sporozoites;Surface;Surveys;Temperature;Testing;Time;tool;Training;transmission process;Uganda;United States National Institutes of Health;uptake;vector;Vector-transmitted infectious disease;Work

PROJECT_TITLE: After the flood: Optimal strategies to prevent malaria epidemics caused by severe flooding

STUDY_SECTION: EDIT

STUDY_SECTION_NAME: Etiology, Diagnostic, Intervention and Treatment of Infectious Diseases Study Section[EDIT]


NIH_SPENDING_CATS: Attention Deficit Hyperactivity Disorder (ADHD);Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Genetics;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Neurosciences;Pediatric

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE Cognition is relevant to the origins and outcome of different types of psychopathology, but the specifics of this relationship are not well understood. The NIMH’s RDoC framework encourages examination of transdiagnostic traits, as well as genetics and brain systems, to advance knowledge. We aim to use this approach, along with newly available samples in the field and computational strategies we developed, to validate and demarcate the genetic and neural underpinnings of cognitive systems in relation to ADHD and child psychosocial outcomes.

PI_NAMEs: GE, TIAN  (contact)

PROGRAM_OFFICER_NAME: MEINECKE, DOUGLAS L

PROJECT_TERMS: Address;Adolescent;Affect;age group;Atlases;Attention deficit hyperactivity disorder;Automobile Driving;base;Behavior;behavioral phenotyping;Behavioral Symptoms;biobank;Biological;Brain;Brain imaging;Brain region;Child;Child Psychiatry;Clinic;Clinical Psychology;Cognition;Cognitive;cognitive development;cognitive function;cognitive system;Collaborations;Complex;computer studies;Data;deep learning;Diagnosis;Diagnostic;Dimensions;Disease;driving behavior;Ethnic Origin;Etiology;Executive Dysfunction;executive function;Family Study;functional outcomes;Future;Genes;Genetic;Genetic Models;Genetic Risk;Genetic Variation;genomic variation;Genomics;Goals;Heritability;Hyperactivity;Image;Impairment;improved;Impulsivity;inattention;Investigation;Knowledge;lens;Link;Machine Learning;machine learning model;member;Methods;Modeling;MRI Scans;National Institute of Mental Health;neural;neural circuit;Neuroanatomy;Neurobiology;Neurocognition;neuroimaging;neuroimaging marker;neuropsychiatry;novel;novel therapeutics;Outcome;Patient Care;Pharmacological Treatment;Phenotype;Psychopathology;psychosocial;psychosocial outcome;Public Health;racial diversity;Research;Research Domain Criteria;Resources;response;Risk;risk stratification;Sampling;serial imaging;Statistical Models;Symptoms;System;Taxonomy;Therapeutic;Time;Training;trait;treatment response;treatment stratification;Twin Studies;Youth

PROJECT_TITLE: Leveraging computational strategies to disentangle the genetic and neural underpinnings of ADHD and its associated cognitive systems

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Autoimmune Disease;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Eye Disease and Disorders of Vision;Genetics

ORG_CITY: ROCHESTER

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: Project Narrative. The secretion of saliva is vital for health and this is most commonly appreciated in disorders such as Sjogren's syndrome where salivary flow is markedly decreased. Following nerve stimulation, the secretion of saliva occurs through the finely tuned choreography of changes in intracellular Ca2+ and activation of ion channels and transporters in specific subcellular domains in salivary gland cells. We postulate these processes are disrupted early in disease and using mouse models of Sjogren’s syndrome, coupled with pathway analysis and functional assays, we will define the events which result in a decrease in secretion and the progression of disease, with an ultimate goal of identifying novel molecular pathways targetable for therapeutic intervention.

PI_NAMEs: YULE, DAVID I (contact)

PROGRAM_OFFICER_NAME: CHANDER, PREETHI

PROJECT_TERMS: Acinar Cell;Address;Affect;Agonist;Animals;Autoimmune Diseases;Automobile Driving;Biochemistry;Bioenergetics;Biological Assay;cell type;Cells;Characteristics;Coupled;Coupling;Cytoplasm;Data;Defect;design;Dimethylxanthenone Acetic Acid;Dinucleoside Phosphates;Disease;disease model;Disease Progression;DNA;Electrophysiology (science);Elements;Epithelial Cells;Event;fluid flow;Fluids and Secretions;Gene Activation;Genes;Gland;Goals;Health;human tissue;Image;imaging platform;Immune;immune cell infiltrate;Immune System Diseases;in vivo;in vivo imaging;insight;Interferons;Ion Channel;Ions;Liquid substance;Major salivary gland structure;Measures;Mediating;Metabolic;Mitochondria;Modeling;Molecular;Monitor;Morphology;mouse model;Movement;National Institute of Dental and Craniofacial Research;Nerve;neural;neural stimulation;new therapeutic target;novel;novel therapeutic intervention;Palpable;Parotid Gland;Pathology;Pathway Analysis;Pathway interactions;Patients;Periodicity;Physiological;Population;Process;Production;Property;protein distribution;Proteins;Reactive Oxygen Species;Regulation;response;Role;saliva secretion;Salivary;salivary acinar cell;Salivary Glands;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Sjogren's Syndrome;spatiotemporal;Stimulator of Interferon Genes;Stimulus;Submandibular gland;Therapeutic Intervention;Therapeutically Targetable;Tissue-Specific Gene Expression;transcriptome sequencing;Virus;Water

PROJECT_TITLE: Ca2+ and secretory dynamics in salivary acinar cells

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]