ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Eye Disease and Disorders of Vision;Genetics;Neurosciences

ORG_CITY: SAINT LOUIS

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE This research aims to achieve two goals: to advance our understanding of CRX-linked retinopathies by characterizing mouse models carrying dominant mutations in CRX’s DNA binding domain and the underlying molecular mechanisms; and to establish the feasibility for therapeutic interventions of CRX disease by testing tunable CRX augmentation as a general treatment strategy in mouse models.

PI_NAMEs: CHEN, SHIMING  (contact)

PROGRAM_OFFICER_NAME: NEUHOLD, LISA

PROJECT_TERMS: Address;Aftercare;Age;Age of Onset;Alleles;Binding;Biochemical;Biological Assay;Cell Culture Techniques;Cellular biology;cone-rod dystrophy;CRX protein;deep sequencing;Dependovirus;design;Development;Disease;disease model;DNA Binding;DNA Binding Domain;dominant genetic mutation;Dose;Doxycycline;early onset;efficacy testing;functional genomics;Future;gain of function;Gene Expression;Genes;Genetic;Genome;Genomic approach;Genomics;Goals;Heterozygote;Homeobox;homeodomain;Human;improved;in vitro Assay;Individual;interdisciplinary approach;Knowledge;Leber's amaurosis;Link;loss of function;Maintenance;Measures;Missense Mutation;Modeling;Molecular;Morphology;mouse model;multidisciplinary;Mus;mutant;Mutation;Outcome;Outcomes Research;Pathogenesis;Pathogenicity;Patients;Pattern;Phenotype;Photoreceptors;Process;programs;Property;Proteins;Publishing;Reporting;Research;Retina;Retinal Diseases;Satellite Viruses;Site;Specificity;System;Testing;Tetracyclines;Therapeutic;Therapeutic Intervention;therapy development;tool;transcription factor;Transgenes;Transgenic Organisms;treatment strategy;vector;Vertebrate Photoreceptors;Virus

PROJECT_TITLE: Understanding and treating CRX-linked retinopathies

STUDY_SECTION: BDE

STUDY_SECTION_NAME: Biology and Development of the Eye Study Section[BDE]


ADMINISTERING_IC: AI

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: BOSTON

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: DANA-FARBER CANCER INST

ORG_STATE: MA

PHR: PROJECT NARRATIVE Approximately 38 million people around the globe live with HIV. This grant application will investigate fundamental mechanisms of HIV integration targeting and consequential activation of HIV from its dormant state inside infected cells, which could impact attempts to cure the virus infection. At the same time, the grant will investigate how HIV avoids being detected by innate immune cells that otherwise could thwart the infection process.

PI_NAMEs: ENGELMAN, ALAN N. (contact)

PROGRAM_OFFICER_NAME: NOVAK, LEIA KAYE

PROJECT_TERMS: Affect;Applications Grants;Architecture;Binding;Binding Proteins;Biochemical;bioinformatics tool;C-terminal;Capsid;Capsid Proteins;Cell Nucleus;cell type;Cells;Chromatin;Cleavage And Polyadenylation Specificity Factor;Clinical Trials;Code;Communities;Competence;Complex;Consent;CRISPR/Cas technology;Darkness;Data Set;Dendritic Cells;DNA;DNA Integration;experimental study;Frequencies;Funding;Genes;Genetic Transcription;Genome;Genomic DNA;Genomics;Grant;Heterochromatin;HIV;HIV-1;Human;Human Genome;Immune;Immune signaling;In Vitro;Infection;Infiltration;inhibitor;Innate Immune Response;Integration Host Factors;integration site;Interferon Type I;Knock-in;Knock-out;Left;Length;Licensing;Light;Liquid substance;Macrophage;Maps;Mediating;Membrane;monocyte;novel;Nuclear;Nuclear Pore Complex Proteins;Nuclear Structure;Nucleic Acids;Organelles;Panthera leo;Persons;Phase;Play;Polyadenylation;Positioning Attribute;preference;Process;Proteins;Proteolysis;Proviruses;Radial;reactivation from latency;Research;response;Reverse Transcription;Role;Rotavirus Infections;Seminal;Site;Stress;Structure;T-Lymphocyte;Textbooks;Three Prime Repair Exonuclease 1;Time;tool;trafficking;Transcript;Travel;United States National Institutes of Health;user-friendly;Viral;viral DNA;Viral hepatitis;Viral Proteins;Virus;Virus Diseases;virus host interaction;Virus Integration;Virus Replication;Work;Writing

PROJECT_TITLE: HIV-1 Preintegration Trafficking and Nuclear Localization

STUDY_SECTION: HVCD

STUDY_SECTION_NAME: HIV Molecular Virology, Cell Biology, and Drug Development Study Section[HVCD]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Kidney Disease

ORG_CITY: ATLANTA

ORG_DEPT: PHARMACOLOGY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE: These studies will define novel contribution of RGS14 to the molecular cell signaling mechanisms that regulate parathyroid hormone and FGF23 actions on kidney phosphate transport. The results will be of clinical relevance given the prevalence of secondary hyperparathyroidism and disordered phosphate balance in kidney disease.

PI_NAMEs: FRIEDMAN, PETER A;HEPLER, JOHN R (contact)

PROGRAM_OFFICER_NAME: LEWIS, MECHELLE MAYLEBEN

PROJECT_TERMS: Affect;Attenuated;Back;Binding;Biotin;Brain;C-terminal;Cells;Chronic Kidney Failure;clinically relevant;Code;Complex;Cyclic AMP;Data;Disease;Dissociation;Elements;Epithelial Cells;Equilibrium;Exhibits;FGFR1 gene;G-Protein-Coupled Receptors;genome wide association study;Goals;GTP-Binding Proteins;Guanosine Triphosphate;Heart;Hippocampus;hormone regulation;Hormones;Human;Human Cell Line;inorganic phosphate;insight;Kidney;Kidney Diseases;knock-down;Learning;Ligands;Ligase;Link;MAP Kinase Gene;MAPK Signaling Pathway Pathway;Mediating;Metabolism;Modeling;Molecular;Mus;Mutation;NHERF-1 protein;novel;Osteopenia;Outcome;Patients;PDZ protein;Phosphorylation;Phosphotransferases;Prevalence;Proteins;Proteomics;Proximal Kidney Tubules;PTH gene;Regulation;response;Rodent;Role;scaffold;Scaffolding Protein;Secondary Hyperparathyroidism;Serum;Signal Pathway;Signal Transduction;Site;Small Interfering RNA;sodium-hydrogen exchanger regulatory factor;Synaptic plasticity;Tertiary Protein Structure;Testing;Tissues;uptake;Ventricular Remodeling

PROJECT_TITLE: RGS14 Regulation of Hormone-sensitive NPT2A-mediated Phosphate Transport

STUDY_SECTION: CSME

STUDY_SECTION_NAME: Cell Signaling and Molecular Endocrinology Study Section[CSME]


NIH_SPENDING_CATS: Atherosclerosis;Genetics;Immunotherapy;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

ORG_CITY: SAN FRANCISCO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE Our work focuses on how signaling networks generate complex cellular behaviors such as cell movement and immune cell activation. The ability to control cell migration would be a valuable tool for combating atherosclerosis, inflammation, metastasis, and other pathological processes that occur upon the disruption of cellular guidance mechanisms. Our work on the mechanism of immune cell activation will directly impact our understanding of autoimmune disease, vaccine development, and immunotherapy-based cancer treatments.

PI_NAMEs: WEINER, ORION D (contact)

PROGRAM_OFFICER_NAME: RIGAS, MARC

PROJECT_TERMS: Acceleration;Address;antigen binding;Antigens;Atherosclerosis;Autoimmune Diseases;Behavior;Biosensor;cancer therapy;cell behavior;cell motility;Cell Polarity;cell type;Cells;Cellular biology;Compensation;Complex;Decision Making;Enhancers;Feedback;Gene Activation;immune activation;Immunotherapy;Inflammation;Investigation;Light;Logic;Lymphocyte;Molecular;Mouse Embryonic Stem Cells;Movement;Neoplasm Metastasis;neutrophil;optogenetics;Organism;Pathologic Processes;Pattern;Peptides;Process;promoter;Property;Science;Sea;Shapes;Signal Transduction;Specific qualifier value;System;T-Cell Activation;T-Lymphocyte;Testing;tool;transcription factor;Transcriptional Activation;vaccine development;Visualization;Work

PROJECT_TITLE: Cellular Decision Making

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: NEW YORK

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: PUBLIC HEALTH RELEVANCE Tri-Institutional PhD Program in Chemical Biology (TPCB) Chemistry is at the heart of all biological processes and provides the basis for the vast majority of modern medicines. Established in 2001, TPCB is a leading chemical biology graduate program that provides comprehensive training at the interface of chemistry, biology, and medicine, enabling students to bring quantitative chemical approaches to forefront problems in biomedical research. The program is offered jointly by Memorial Sloan Kettering Cancer Center, The Rockefeller University, and Weill Cornell Medical College, three premier research institutions that form a Tri-Institutional campus in the heart of New York City.

PI_NAMEs: TAN, DEREK S (contact)

PROGRAM_OFFICER_NAME: PAUL, MOUSHUMI

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - B[TWD-B]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Influenza;Pneumonia and Influenza;Prevention

ORG_CITY: ATHENS

ORG_NAME: UNIVERSITY OF GEORGIA

PHR: NARRATIVE Methodologies will be developed for the automated synthesis of complex glycans with full control over branching of N-glycans, installation of bisecting GlcNAc, patterns of fucosylation, I-branching, and sulfation of poly-LacNAc chains. The new methodologies will be applied to prepare a collection of complex N-glycans that resemble structures expressed by respiratory tissue. The resulting compounds will be used to develop an integrated technology platform to examine host-pathogen interactions with a focus on Influenza A viruses. 1

PI_NAMEs: BOONS, GEERT-JAN  (contact)

PROGRAM_OFFICER_NAME: BOZICK, BROOKE ALLISON

PROJECT_TITLE: Automated chemo-enzymatic synthesis of N-glycans for host-pathogen interactions

STUDY_SECTION: SBCA

STUDY_SECTION_NAME: Synthetic and Biological Chemistry A Study Section[SBCA]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: RICHMOND

ORG_NAME: VA VETERANS ADMINISTRATION HOSPITAL

ORG_STATE: VA

PHR: Premature heart beats, so called “Premature Ventricular Contractions” (PVCs), are commonly seen in patients with heart failure. PVCs have been recognized to debilitate the heart and cause heart failure, called "PVC‐cardiomyopathy". This cardiomyopathy also carries significant financial burden in the care of our veterans. A PVC-Cardiomyopathy canine model has been developed and used to understand the mechanism of this reversible CM. The main purpose of this study is to validate a similar PVC- Cardiomyopathy model in the swine species. We anticipate that this study will help us understand the mechanism of this heart condition, leading to better prevention and treatment of PVC-Cardiomyopathy and identification of high-risk patients with significant impact in heart failure admission, mortality and VA healthcare spending.

PI_NAMEs: HUIZAR, JOSE FRANCISCO (contact)

PROJECT_TITLE: Validation of Premature Ventricular Contraction-induced Cardiomyopathy on a Swine Model


ADMINISTERING_IC: TW

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Lung;Social Determinants of Health

ORG_CITY: MBARARA

ORG_COUNTRY: UGANDA

ORG_FIPS: UG

ORG_NAME: MBARARA UNIVERSITY/SCIENCE/ TECHNOLOGY

PHR: 2.0 Project narrative Chronic, non-communicable diseases (NCDs) now account for over half of morbidity and quality of life reductions in resource-limited settings. Of particular importance is the growing epidemic of multi-morbidity, or the accumulation of chronic conditions, including combinations of both non-communicable and communicable conditions on well-being and quality of life. However, the majority of disease treatment programs, donor funding mechanisms and research infrastructure focuses on infectious diseases, and most such programs are siloed. This D43 training program application will directly respond to PAR-18-901 (“Chronic, Non- Communicable Diseases and Disorders Across the Lifespan: Fogarty International Research Training Award”) by strengthening the capacity of Ugandan junior investigators to pursue research careers on NCDs and multi- morbidity through a proven co-mentoring model of sustained training. Our over-arching goal is to build a foundation of independent junior investigators upon which to build a regional center of excellence in the study of multi-morbidity in Uganda.

PI_NAMEs: BAJUNIRWE, FRANCIS  (contact)

PROGRAM_OFFICER_NAME: LEVINTOVA, MARYA

PROJECT_TERMS: Accidents;Air Pollution;Area;Attention;Behavioral;Caring;Chronic;Chronic Obstructive Pulmonary Disease;Clinical;Clinical Research;Communicable Diseases;comorbidity;Diabetes Mellitus;Diagnostic;Disease;Environmental Risk Factor;Epidemic;Faculty;Funding Mechanisms;General Hospitals;Health;health determinants;HIV;Human;Hypertension;Infrastructure;Laboratories;Laboratory Research;Low income;Lung Diseases;Malignant Neoplasms;Massachusetts;Measures;member;Mentorship;Morbidity - disease rate;multidisciplinary;multiple chronic conditions;Occupational Exposure;Outcome;Personal Satisfaction;Pneumonia;Postdoctoral Fellow;programs;quality assurance;Quality of life;Research;Research Infrastructure;Research Training;Resource-limited setting;Resources;Risk Factors;Science;social;social health determinants;Technology;Testing;Time;Training;Training Programs;treatment program;Uganda;Universities

PROJECT_TITLE: Multi-morbidity in Uganda Research Capacity Initiative (MURCI) at Mbarara University of Science and Technology


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_CITY: SEATTLE

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative The population science research conducted by affiliates at the Center for Studies in Demography and Ecology (CSDE) contributes towards NICHD's mission to understand human development, improve reproductive health, enhance the lives of children and adolescents, and optimize abilities for all. CSDE scientists accomplish this through their research in demography, reproductive health, and population health. CSDE especially supports their efforts by catalyzing new research and launching early career investigators' research independence at the intersection of demography, data innovation, and population disparities.

PI_NAMEs: CURRAN, SARA R. (contact)

PROGRAM_OFFICER_NAME: CLARK, REBECCA L

PROJECT_TERMS: Address;Adolescent;Area;Award;biodemography;career;Child;Collaborations;college;Communication;Connective Tissue;Consultations;Data;data enclave;Data Science;Demographer;Demography;Development;Disparity population;early-career faculty;Ecology;Educational workshop;Environment;Event;Faculty;faculty community;faculty research;Fee-for-Service Plans;Fostering;Funding;Grant;Health;High Performance Computing;high reward;Home;Household and Family;Human;Human Development;improved;Inequality;Infrastructure;innovation;Institution;interest;Knowledge;Lead;Leadership;Learning;Logistics;Measurement;Measures;meetings;Mentors;Methodology;Methods;migration;Mission;National Institute of Child Health and Human Development;novel strategies;outreach;Personal Satisfaction;Persons;Population;Population Dynamics;population health;Population Process;Population Research;Population Sciences;Productivity;programs;Reproductive Health;Research;research data dissemination;Research Personnel;Resources;Schools;Science;Scientific Advances and Accomplishments;scientific organization;Scientist;Series;Services;statistics;Students;Time;Training;Translational Research;virtual;Work;Writing

PROJECT_TITLE: Demography Center


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science

PROJECT_TERMS: Accountability;Area;Budgets;Collaborations;Communication;Communities;community building;community engagement;Creativeness;Data;Databases;Dedications;Demography;Educational workshop;Ensure;Environment;Evaluation;Event;experience;Faculty;General Population;Grant;Health;Household and Family;Human;Human Subject Research;Individual;information gathering;Institution;Investments;Leadership;Logistics;Measurement;meetings;Methods;migration;Mission;National Institute of Child Health and Human Development;operation;outreach;payment;Personal Satisfaction;Persons;Population;Population Process;Population Sciences;Preparation;Printing;Problem Solving;Process;Productivity;programs;Progress Reports;Publications;Qualifying;Recommendation;Regulation;Reporting;Research;Research Personnel;Research Project Grants;Resources;Running;Schedule;Scholarship;Scientist;Secure;Service provision;Services;skills;Surveys;Time;time use;tool;Translating;United States National Institutes of Health;Universities;virtual platform;Washington;web site;working group

PROJECT_TITLE: Administrative Core


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Diabetes;Genetics

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Project Narrative Beta cell dysfunction in diabetes results from prolonged hyperglycemia, termed glucose toxicity. In this proposal, we will explore specific molecular mechanisms of glucose toxicity in pancreatic beta cells and test therapeutic interventions to mitigate these effects. These studies could lead to the development of therapeutic strategies to treat beta cell dysfunction in diabetes.

PI_NAMEs: SCOTT, DONALD K. (contact)

PROGRAM_OFFICER_NAME: WANG, XUJING

PROJECT_TERMS: Affect;Alternative Splicing;Antioxidants;Apoptosis;Apoptotic;Beta Cell;Binding;Binding Proteins;blood glucose regulation;Carbohydrates;Cell Death;Cell Physiology;Cell Proliferation;Cell Survival;Cessation of life;Diabetes Mellitus;diabetic;Diabetic mouse;Drug Targeting;exhaust;exhaustion;experience;experimental study;feasibility testing;Functional disorder;gain of function;Genes;genetic approach;Genetic Transcription;Glucose;glucose metabolism;Human;Hyperglycemia;Insulin;Insulin Resistance;islet;loss of function;Mediating;Mediator;Metabolic;Modeling;Molecular;mouse model;Names;Non-Insulin-Dependent Diabetes Mellitus;novel therapeutics;Nuclear;Nuclear Export;Obesity;overexpression;Pathogenesis;Pathway interactions;pharmacologic;preservation;Production;promoter;Protein Isoforms;Response Elements;Rodent;Rodent Model;Series;Signal Transduction;Site;Structure of beta Cell of islet;Symptoms;targeted treatment;Testing;therapeutic development;therapeutic evaluation;Therapeutic Intervention;therapy design;Toxic effect;transcription factor;TXNIP gene;Type 2 diabetic

PROJECT_TITLE: Alleviation of Glucotoxicity in Pancreatic Beta Cells

STUDY_SECTION: BMDM

STUDY_SECTION_NAME: Basic Mechanisms of Diabetes and Metabolism Study Section[BMDM]


NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

PI_NAMEs: GOODREAU, STEVEN M. (contact)

PROJECT_TERMS: Achievement;Applications Grants;Area;career;career development;Collaborations;college;Communication;Communities;Consultations;Data;Dedications;Demography;design;Development;Discipline;Disparity population;early-career faculty;Educational workshop;Ensure;Evaluation;Event;Faculty;Feedback;Fostering;Funding;Future;Generations;Goals;Grant;Health Sciences;high reward;high risk;Human;Individual;innovation;Institution;interdisciplinary collaboration;Investments;Knowledge;Mentors;Mentorship;Mission;novel;Personal Satisfaction;Play;Population;Population Dynamics;Population Research;Population Sciences;Process;Productivity;programs;Research;research and development;Research Infrastructure;Research Personnel;Research Project Grants;Resources;Role;Scholarship;Schools;Scientist;Series;Services;Shapes;Societies;success;summer research;Support System;United States National Institutes of Health;working group;Writing

PROJECT_TITLE: Development Core


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Networking and Information Technology R&D (NITRD)

PI_NAMEs: EISENBERG, DANIEL T A (contact)

PROJECT_TERMS: Address;Architecture;biodemography;career;cluster computing;Code;Communities;Complement;Computer software;Consultations;Custom;Data;data centers;data management;Databases;Demography;Development;Disparity population;Drops;Educational workshop;Ensure;experience;Funding;Goals;health data;Health Sciences;High Performance Computing;Infrastructure;innovation;interest;Laboratories;laboratory facility;Leadership;Methodology;Modernization;novel;novel strategies;Peer Review;Performance;Population;Population Dynamics;population health;Population Research;Population Sciences;Productivity;programs;relational database;Reproducibility;Reproduction;Research;Research Personnel;Resources;response;Sampling;Scientist;Secure;Security;Series;Services;skills;Survey Methodology;Surveys;Training;virtual environment;Work

PROJECT_TITLE: Scientific/Technical Core


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hematology;Racial and Ethnic Minority Health Research;Regenerative Medicine;Social Determinants of Health;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Umbilical Cord Blood/ Placenta;Stem Cell Research - Umbilical Cord Blood/ Placenta - Human;Transplantation

ORG_NAME: FRED HUTCHINSON CANCER CENTER

PHR: Project Narrative We will study how survival after transplantation can be improved for patients of all races through a better understanding of the genes that help to eliminate cancer cells.This information will help to lower risks through individualized treatment options for future patients.

PI_NAMEs: PETERSDORF, EFFIE W (contact)

PROGRAM_OFFICER_NAME: DUGLAS TABOR, YVONNE

PROJECT_TERMS: African;African American;Allogenic;Asian;Asian Americans;Binding;cancer cell;cancer health disparity;caucasian American;Caucasians;cell transformation;Cells;Characteristics;Clinical;Complex;Country;Data;Disease-Free Survival;Disparity;Donor person;Donor Selection;Exons;Failure;Future;Gene Expression;Genes;Genetic;Genetic Polymorphism;Genotype;Germ Lines;Goals;Graft Rejection;graft vs host disease;Haplotypes;Hematopoietic Neoplasms;Hematopoietic Stem Cell Transplantation;high risk;Hispanic;Hispanic Americans;Histocompatibility;HLA-B Antigens;HLA-DQ Antigens;Homologous Transplantation;Human;Immunogenetics;improved;individualized medicine;innovation;Investigation;Laboratories;Life;Ligands;Methods;Mica;Modeling;mortality;Nature;non-genetic;novel;open data;Outcome;outcome disparities;Pathway interactions;Patient Care;Patients;Peptide Leader Sequences;Peptides;Phase;Population;prospective;Race;racial disparity;racial diversity;racial population;receptor;receptor expression;Relapse;relapse risk;Risk;Risk Assessment;Role;Shapes;success;Supplementation;survival disparity;survival outcome;Survival Rate;survivorship;Tissues;Transplant Recipients;Transplantation;tumor;Umbilical Cord Blood Transplantation;Variant;Work

PROJECT_TITLE: Immunogenetics of Outcomes Disparities After Allogeneic HCT

STUDY_SECTION: BMCD

STUDY_SECTION_NAME: Basic Mechanisms of Cancer Health Disparities Study Section[BMCD]


NIH_SPENDING_CATS: Genetics;Human Genome

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: The repair of DNA double-strand breaks (DSBs) is essential to maintain genome integrity and to guard against cancer in humans. We will use the yeast Saccharomyces cerevisiae model system to address the mechanisms of DSB repair; specifically, we will determine how repair proteins interacts with chromatin remodeling complexes to process DSB ends, and define the roles of the Mre11 complex and nucleosome assembly factors in repair of collapsed replication forks. In the long term we believe that mechanisms under investigation in this proposal will provide new insight and fundamental knowledge for understanding disease caused by genomic instability.

PI_NAMEs: SYMINGTON, LORRAINE S (contact)

PROGRAM_OFFICER_NAME: REDDY, MICHAEL K

PROJECT_TERMS: Address;Biological Models;Cell Survival;Cells;Cellular Metabolic Process;Chemotherapy and/or radiation;Chromatin;chromatin remodeling;Chromatin Remodeling Factor;Chromatin Structure;Chromosomal Breaks;chromosome loss;Complex;Coupled;cytotoxic;Defect;Development;Disease;DNA biosynthesis;DNA Damage;DNA Double Strand Break;DNA Repair;DNA Repair Gene;DNA replication fork;Double Strand Break Repair;Endonuclease I;Event;Excision;Genetic Recombination;genome integrity;Genomic Instability;Goals;homologous recombination;Human;Immunologics;insight;Investigation;Knowledge;Lesion;Malignant Neoplasms;Methodology;Micrococcal nuclease digestion of chromatin followed by sequencing;Neurologic;Normal Cell;novel;novel therapeutics;Nucleosomes;Pathway interactions;practical application;Predisposition;Process;programs;Proteins;Regulation;repaired;replication stress;Research;Resistance;Role;Saccharomyces cerevisiae;Sister Chromatid;Site;System;targeted treatment;Toxic effect;Yeasts

PROJECT_TITLE: Mechanism and regulation of DNA double-strand break repair

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Autoimmune Disease;Brain Disorders;Cerebrovascular;Multiple Sclerosis;Neurodegenerative;Neurosciences

ORG_CITY: DURHAM

ORG_DEPT: NEUROSURGERY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Pericyte-Macrophage Interactions Maintain CNS Immune Tolerance NARRATIVE The lesions that arise in the brain and spinal cord of patients with MS are associated with infiltrating T cells that initially accumulate at the borders of the central nervous system (CNS). Events at the borders of the CNS acts as critical checkpoints on the migration path of an autoreactive T cell. This project will investigate a novel cellular interaction between pericytes and macrophages at the borders of the CNS.

PI_NAMEs: FILIANO, ANTHONY J (contact)

PROGRAM_OFFICER_NAME: UTZ, URSULA

PROJECT_TERMS: angiogenesis;Antigen Presentation;Antigen-Presenting Cells;antigen-specific T cells;Antigens;Area;Autoimmune Diseases of the Nervous System;autoreactive T cell;Biological Assay;Blood;Blood - brain barrier anatomy;Blood flow;Blood Vessels;Brain;Brain Injuries;brain pericytes;cell type;Cells;Central Nervous System;CNS autoimmune disease;Communication;CRISPR/Cas technology;Cytoplasm;Cytoplasmic Organelle;Data;Demyelinations;Environment;Event;Experimental Autoimmune Encephalomyelitis;Extravasation;Family;Genes;Genetic;Genetic Polymorphism;genome wide association study;Germ Cells;healing;Immune;Immune Tolerance;immunosuppressed;in vivo;Infiltration;Inflammation;Inflammatory;LDL-Receptor Related Protein 1;Lesion;Lipoprotein Receptor;Macrophage;Mediating;Membrane;Meningeal;Meninges;mesenchymal stromal cell;Messenger RNA;migration;Modeling;Multiple Sclerosis;multiple sclerosis patient;Mus;Myelin;Nature;Nerve Degeneration;neuroinflammation;Neurologic Symptoms;neurovascular unit;new therapeutic target;novel;novel therapeutics;Pericytes;Peripheral;Phenotype;Process;programs;Proteins;RNA;RNA Processing;Role;scavenger receptor;Signal Transduction;Site;Spinal Cord;Surface;T cell infiltration;T cell response;T-Cell Activation;T-Lymphocyte;Testing;Tissues;trafficking;uptake


NIH_SPENDING_CATS: Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Infectious Diseases;Malaria;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Rare Diseases;Vector-Borne Diseases

ORG_DEPT: PEDIATRICS

PHR: Project Narrative: Malaria is a leading killer of children worldwide, but efforts to develop a preventive vaccine have failed due to our limited understanding of the immune response to infection. We will investigate the role of gamma-delta T cells, a unique lymphocyte subset with innate reactivity to malaria, in protecting infants from malaria. We will determine how gamma-delta T cells respond to malaria antigens encountered before birth (using cord blood samples from infants with and without placental malaria) as well as postnatally, in response to malaria infections acquired during infancy.

PI_NAMEs: FEENEY, MARGARET E (contact)

PROGRAM_OFFICER_NAME: PESCE, JOHN T

PROJECT_TERMS: Acute;adaptive immune response;adaptive immunity;Adult;Africa South of the Sahara;Anti-malarials;Antibodies;Antigen Presentation;Antigens;Attenuated;Birth;Blood specimen;butyrophilin;Cells;Cellular biology;Cessation of life;Characteristics;Child;Chronic;Circulation;cohort;cytokine;Cytoprotection;Data;Dendritic Cells;Development;differential expression;early childhood;Effector Cell;effector T cell;Environment;Exhibits;experimental study;Exposure to;extracellular;fetal;fetal blood;Fetus;Fostering;Frequencies;Funding;Gene Expression;Genes;Germ Lines;global health;Grant;granulysin;Granzyme;Growth;Heterogeneity;Human;Immune;Immune response;Immunity;Immunize;immunoregulation;improved;in utero;In Vitro;in vivo;Individual;infancy;Infant;infant infection;Infection;Inflammatory;Interferon Type II;Life;Lymphocyte;Lymphocyte Subset;Malaria;malaria infection;Malaria Vaccines;Mediating;Mononuclear;Mothers;Mus;Natural Immunity;neonate;novel;Parasitemia;Parasites;Peripheral Blood Mononuclear Cell;Phagocytosis;Phenotype;Placenta;placental malaria;Plasmodium falciparum;Play;Population;postnatal;Pregnancy;prenatal;prenatal exposure;Preventive vaccine;Primary Infection;prospective;Recording of previous events;response;Role;Sampling;single cell sequencing;Source;Sporozoites;T cell response;T-Cell Activation;T-Cell Development;T-Cell Proliferation;T-cell receptor repertoire;T-Lymphocyte;Technology;TNF gene;transcriptomics;Umbilical Cord Blood;uptake;vaccine immunogenicity;volunteer;Work;γδ T cells

PROJECT_TITLE: The role of γδ T cells in fetal and infant immune defense against malaria

STUDY_SECTION: IHD

STUDY_SECTION_NAME: Immunity and Host Defense Study Section[IHD]


PHR: PROJECT NARRATIVE We have previously identified antiviral compounds targeting the HIV capsid protein (CA) that can stabilize or destabilize the capsid core. This project will help to understand the structural basis of HIV capsid core stability, which controls many steps in the virus life cycle. These studies should identify lead compounds with improved pharmacological properties, high potency, and improved resistance profiles.

PI_NAMEs: SARAFIANOS, STEFAN G (contact);WANG, ZHENGQIANG

PROGRAM_OFFICER_NAME: SANDERS, BRIGITTE E

PROJECT_TERMS: Affect;analog;antagonist;Anti-viral Agents;Anti-viral resistance;base;Basic Science;Binding;Biological Assay;biophysical analysis;Biophysics;Calorimetry;Capsid;Capsid Proteins;Cells;chemical synthesis;Clinical Trials;Collaborations;Complex;crosslink;Crystallography;cytotoxicity;Data;design;Development;Disclosure;drug action;Drug Kinetics;Drug resistance;Drug Targeting;early phase clinical trial;Electron Microscopy;Funding;Genes;HIV;HIV-1;Image;Immune;Immune Evasion;Immune response;Immunologic Surveillance;improved;In Vitro;in vivo;Infection;inhibitor;Injectable;innovation;Integration Host Factors;integration site;Interferons;invention;Kinetics;knockout gene;Lead;Length;Letters;Life Cycle Stages;Manuscripts;Mediating;Metabolic;Minnesota;Molecular;Monitor;mutant;Mutation;nanomolar;novel;novel strategies;Nuclear;Patients;Peptides;pharmacologic;Phase II/III Clinical Trial;Play;premature;Property;Proteins;Protomer;Publishing;Reporting;Research;Resistance;resistance mutation;Resistance profile;response;Reverse Transcription;Role;Sampling;Series;Site;Solubility;Structure;Structure-Activity Relationship;synergism;Therapeutic;tool;translational study;TREX1 gene;Up-Regulation;Viral;viral DNA;virology;Virus;X-Ray Crystallography

PROJECT_TITLE: Development of HIV capsid-targeting antivirals that affect immune response by modulating capsid stability and have improved resistance profiles


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: Newark

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF DELAWARE

ORG_STATE: DE

PHR: PROJECT NARRATIVE Cardiovascular diseases such as heart disease, heart failure, and stroke remain the number one cause of death in the U.S. for both men and women. In this application, we seek to continue our work in the Center of Biomedical Research Excellence in Cardiovascular Health in Phase II with the aims to catalyze cardiovascular health research at the University of Delaware by fostering the independent research careers of a new Phase II team of researchers, strengthening the cardiovascular research core, and continuing to grow the number of cardiovascular researchers in Delaware.

PI_NAMEs: EDWARDS, DAVID G (contact)

PROGRAM_OFFICER_NAME: KOVBASNJUK, OLGA NIKOLAEVNA

PROJECT_TERMS: Affect;Age;Behavior;bioimaging;Blood Glucose;Blood Pressure;Blood Vessels;Body Weight;Cardiovascular Diseases;cardiovascular health;Cardiovascular Physiology;cardiovascular risk factor;Cardiovascular system;career;career development;Cause of Death;Centers of Research Excellence;Cessation of life;Cholesterol;Chronic;Chronic Kidney Failure;Clinical;cohort;combat;Coronary Arteriosclerosis;Delaware;design;effective intervention;Equipment;Event;Faculty;Faculty Recruitment;Fostering;Funding;Goals;Grant;Healthy Eating;Heart Diseases;Heart failure;Human Resources;imaging facilities;Impairment;improved;Infrastructure;Interdisciplinary Study;Intervention;Leadership;men;Mentors;Metabolic syndrome;modifiable behavior;multidisciplinary;novel;Obesity;Organ;Pattern;Personal Satisfaction;Phase;physical inactivity;Positioning Attribute;Program Development;programs;Research;Research Infrastructure;Research Personnel;Resources;Risk Factors;Smoking;Stroke;success;Testing;Training;Translational Research;Unhealthy Diet;Universities;Woman;Work


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cardiovascular

PROJECT_TERMS: Advisory Committees;cardiovascular health;Cardiovascular Physiology;Cardiovascular system;career;career development;Centers of Research Excellence;cohort;Delaware;Development Plans;effective intervention;Ensure;Evaluation;Faculty;Faculty Recruitment;formative assessment;Fostering;Funding;Goals;Grant;Individual;Infrastructure;Interdisciplinary Study;Leadership;meetings;Mentors;Methods;Monitor;Office of Administrative Management;peer coaching;Phase;Positioning Attribute;Productivity;Program Development;programs;recruit;Research;research faculty;Research Personnel;Research Project Grants;Research Support;Resources;Structure;success;Universities

PROJECT_TITLE: Center of Biomedical Research Excellence in Cardiovascular Health Administrative Core


ED_INST_TYPE: SCHOOLS OF PHARMACY

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: The melanocortin pathway has been identified in mice and humans, to regulate obesity. This research project proposes to discover melanocortin-3 receptor (MC3R) selective molecules and study the role of the MC3R in energy/metabolic homeostasis. These goals are important for target validation and rational design and drug discovery of molecules as potential therapeutic agents regarding obesity, type 2 diabetes, and associated diseases.

PI_NAMEs: GIULIANOTTI, MARC ;HASKELL-LUEVANO, CARRIE  (contact)

PROGRAM_OFFICER_NAME: LI, YAN

PROJECT_TERMS: Acute;Age;Agonist;antagonist;antagonist G;ART protein;Basic Science;Biological;blood glucose regulation;Blood Pressure;Body mass index;Brain;Bypass;candidate selection;Central Nervous System;Collection;Complex;Country;Coupled;Data;design;Developed Countries;Diet;Disease;drug discovery;Eating;Energy Intake;Energy Metabolism;erection;Exercise;experimental study;Fatty acid glycerol esters;Feeding behaviors;Food Energy;Food Intake Regulation;Genes;Genetic;genetic manipulation;Goals;GTP-Binding Proteins;Heart Diseases;Homeostasis;Human;Hyperphagia;Hypertension;Hypothalamic structure;In Vitro;in vivo;in vivo evaluation;Knockout Mice;Lead;lead candidate;Ligands;male;Mediating;Melanocortin 3 Receptor;Melanocortin 4 Receptor;melanocortin receptor;Metabolic;metabolic phenotype;Modification;Molecular Probes;Morbidity - disease rate;mouse genetics;Mus;Neurons;Neurosecretory Systems;Non-Insulin-Dependent Diabetes Mellitus;Obesity;Obesity associated disease;obesity treatment;Outcome;Pathway interactions;Peer Review;Peptides;Persons;Pharmaceutical Chemistry;Phenotype;Physiological;Physiology;Population;preprohormone;Pro-Opiomelanocortin;Publications;rational design;receptor;Receptor Activation;Regulation;Reporting;Research;Research Project Grants;Risk Factors;Role;Satiation;screening;side effect;small molecule;small molecule libraries;Stroke;Therapeutic;Therapeutic Agents;tool;Transcript;United States;Validation;Weight;Wild Type Mouse

PROJECT_TITLE: Melanocortin Receptor Selective Ligands

STUDY_SECTION: DDNS

STUDY_SECTION_NAME: Drug Discovery for the Nervous System Study Section[DDNS]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

PHR: Project Narrative This project addresses several issues of central importance to the understanding of how cardiac radiation treats ventricular arrhythmias, a significant cause of morbidity and mortality. This proposal tests the hypothesis that radiation treatment transcriptionally regulates the expression of ion channel subunits that regulate cardiac conduction. Defining the acute effects of irradiation on the electrical substrate is expected to facilitate clinical implementation of this promising new anti-arrhythmic therapy and advance the field of cardiac radiation biology.

PI_NAMEs: RENTSCHLER, STACEY LYNN (contact);SCHWARZ, JULIE KRISTINA

PROGRAM_OFFICER_NAME: BALIJEPALLI, RAVI C

PROJECT_TERMS: Ablation;Acceleration;Acute;Address;Animal Model;Anti-Arrhythmia Agents;Area;Arrhythmia;Biological;Biological Assay;Biological Markers;Cancer Patient;Carbon ion;Cardiac;Cardiac ablation;Cardiac Electrophysiologic Techniques;Cardiac Myocytes;Cardiotoxicity;Chemical-Induced Change;Chromatin;Chromatin Remodeling Factor;Cicatrix;circulating biomarkers;Clinical;clinical effect;clinical implementation;Clinical Trials;cohort;Connexin 43;conventional therapy;Coupled;Dangerousness;Data;Disease;Dose;Down-Regulation;Electrophysiology (science);Epigenetic Process;Family suidae;Fibrosis;Focused Ultrasound Therapy;fractionated radiation;Gap Junctions;Gene Expression;Genes;Genetic;Genetic Models;Genetic Transcription;Heart;Heart Arrest;Heart Diseases;Heart failure;High-Throughput Nucleotide Sequencing;Histologic;Hospitals;Human;Image;innovation;insight;Ion Channel;Ionizing radiation;irradiation;Left;loss of function;Maps;Measures;Mediating;Messenger RNA;MicroRNAs;Modeling;Molecular;Monitor;Morbidity - disease rate;mortality;mouse model;Mus;Myocardial;Myocardial Infarction;Myocardium;notch protein;Optics;Output;participant enrollment;Pathway interactions;Patient Representative;Patients;Phenotype;Physiological;Plasma;porcine model;prevent;programs;Prospective cohort;protein expression;Protein Inhibition;Proteins;Radiation;Radiation Dose Unit;radiation effect;Radiation therapy;Radiobiology;Reactive Oxygen Species;Refractory;response;Safety;Serum;Signal Transduction;single fraction radiation;Slice;Sodium Channel;sodium channel proteins;specific biomarkers;sudden cardiac death;System;Techniques;Testing;Therapeutic Effect;Therapy trial;Tissues;transcriptional reprogramming;Translating;Transposase;treatment effect;Treatment Efficacy;Ventricular;Ventricular Arrhythmia;Ventricular Tachycardia

PROJECT_TITLE: Mechanistic Basis of Cardiac Irradiation as a Therapy for Ventricular Tachycardia

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-TDPS-R(01)]


PHR: PROJECT NARRATIVE This project proposes to study the function of retinoic acid signaling in embryo implantation and uterine decidualization. Unveiling of retinoic acid receptor regulated genes during decidualization will dramatically increase our understanding of its function during this process. Results from this study will have a lasting impact on implantation biology and drug discovery.

PI_NAMEs: MA, LIANG  (contact)

PROGRAM_OFFICER_NAME: RAVINDRANATH, NEELAKANTA

PROJECT_TERMS: Abnormal placentation;adverse pregnancy outcome;Biology;Birth;Cell Communication;Cell model;Cells;Conceptus;conditional knockout;Contraceptive Agents;Data;Decidual Cell;Decidual Cell Reactions;Defect;Development;Dominant-Negative Mutation;drug discovery;Endometrial Stromal Cell;endometriosis;Epithelium;Exhibits;Failure;failure Implantation;female fertility;Fertilization in Vitro;Fetal Growth;Fibroblast Growth Factor;Fibroblasts;follow-up;Gene Expression Profiling;Gene Proteins;Gene Silencing;gene synthesis;Genes;Genetic;Genetic Transcription;genome-wide;Growth Factor;high throughput screening;Homeodomain Proteins;hormonal signals;Human;human embryonic stem cell;Implant;implantation;improved;Infertility;Knock-out;Knockout Mice;Limb Development;loss of function;LoxP-flanked allele;Maps;Mediating;mouse model;Mus;Mutant Strains Mice;natural Blastocyst Implantation;novel;Pathway interactions;Phenotype;Pregnancy;pregnancy failure;Procedures;Process;Progesterone;Prolactin;Proliferating;promoter;Regulator Genes;Reporting;Reproduction;response;Retinoic Acid Receptor;screening;Screening procedure;Signal Pathway;Signal Repression;Signal Transduction;Small Interfering RNA;success;System;Technology;Tissues;tool;transcriptome sequencing;Tretinoin;Uterus;whole genome

PROJECT_TITLE: Retinoic acid signaling in decidualization

STUDY_SECTION: PN

STUDY_SECTION_NAME: Pregnancy and Neonatology Study Section[PN]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Building Research Capacity at Institutions with Limited NIH Funding;Cardiovascular;Clinical Research

PI_NAMEs: LENNON, SHANNON  (contact)

PROJECT_TERMS: Acceleration;arm;bioimaging;Biometry;cardiovascular health;Cardiovascular Physiology;Cardiovascular system;Cell Culture Techniques;Centers of Research Excellence;Collaborations;Complex;Confocal Microscopy;data management;Dedications;Delaware;effective intervention;Equipment;equipment acquisition;Faculty;Funding;Goals;Health Sciences;Human Resources;Image;imaging facilities;Infrastructure;instrumentation;Interdisciplinary Study;Investigation;Microscope;Motor;multi-photon;Personnel Management;Phase;Postdoctoral Fellow;Research;Research Personnel;Resolution;Scanning;Science;Side;Speed;success;Technology;Ultrasonography;ultrasound;United States National Institutes of Health;Universities

PROJECT_TITLE: Center of Biomedical Research Excellence in Cardiovascular Health Research Core


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Macular Degeneration;Neurodegenerative;Neurosciences

ORG_CITY: WORCESTER

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: PI: Claudio Punzo Project Narrative Retinal-pigmented epithelium atrophy (RPE) that results in geographic atrophy (GA) in humans is one of the leading causes for blindness in the industrialized world. This is because there is currently no treatment available for to prevent RPE atrophy and thus GA, which is an advanced form of Age-related Macular Degeneration (AMD). The disease is characterized by focal RPE cell loss. Because the RPE maintains photoreceptor homeostasis, photoreceptors die as well, which then leads to vision loss. Recently, it has been recognized that the high metabolic demands of photoreceptors may contribute to disease progression in AMD, in particular, because photoreceptors and RPE metabolism are tightly linked. To study how photoreceptor metabolism can affect the RPE we generated an animal model in which photoreceptor metabolism is altered. These mice develop AMD-like characteristics including focal RPE atrophy. In this project we propose to investigate what exactly causes the pathologies seen in these mice and how the RPE deteriorates over time. This will help us understand how altered photoreceptor metabolism can affect RPE health.

PI_NAMEs: PUNZO, CLAUDIO  (contact)

PROGRAM_OFFICER_NAME: NEUHOLD, LISA

PROJECT_TERMS: advanced disease;Affect;Age;Age related macular degeneration;Animal Model;Area;Atrophic;Autophagocytosis;Blindness;Candidate Disease Gene;Cell Death;Cells;Cellular Metabolic Process;Cessation of life;Characteristics;Complement;Complex;Cone;Data;density;Deposition;Derivation procedure;Deterioration;dietary;Disease;Disease Progression;Docosahexaenoic acid supplementation;Drusen;Ecosystem;Electroporation;Event;Fatty Acids;FRAP1 gene;Functional disorder;Gene Expression;Genes;Genetic Transcription;geographic atrophy;Glucose;Glycolysis;Goals;Health;Hexokinase 2;Homeostasis;Human;Impairment;in vivo;Individual;Industrialization;Link;lipidomics;Lipoproteins;Literature;Location;Long-Term Effects;Lysosomes;macula;Mediating;Metabolic;Metabolism;metabolomics;Modeling;Mus;Nutrient;Pathogenesis;Pathology;Pathway interactions;Patients;Phase;Phosphotransferases;photoreceptor degeneration;Photoreceptors;plasmid DNA;postnatal;prevent;Procedures;Process;Production;Proteins;Proto-Oncogene Proteins c-akt;Publishing;Research;response;Retina;Retinitis Pigmentosa;Rod;Rotation;Signal Pathway;Signal Transduction;Stress;Structure of retinal pigment epithelium;Testing;Time;transcriptome sequencing;transcriptomics;Translations;Tuberous Sclerosis;Vertebrate Photoreceptors

PROJECT_TITLE: Identifying the cause for photoreceptor-mediated retinal-pigmented epithelium atrophy

STUDY_SECTION: BVS

STUDY_SECTION_NAME: Biology of the Visual System Study Section[BVS]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Eye Disease and Disorders of Vision;Infectious Diseases;Rare Diseases

PHR: PROJECT NARRATIVE The WHO currently recommends annual mass azithromycin distribution in trachoma-endemic areas until the district-level prevalence of trachomatous inflammation-follicular (TF) drops below 5%, an arbitrary threshold that has never been empirically validated and is now becoming more important as we approach the endgame. Our proposal assesses whether annual azithromycin distribution can be stopped in communities with TF prevalence in the range of 0% to 20%, and to evaluate alternative indicators of trachoma transmission. We anticipate that the results of this study will provide evidence that azithromycin distributions can be stopped earlier, thus reducing distribution of unnecessary antibiotic, and evidence that true infection can be locally eliminated even in the setting of a low prevalence of TF.

PI_NAMEs: LIETMAN, THOMAS M;OLDENBURG, CATHERINE ELIZABETH (contact)

PROGRAM_OFFICER_NAME: LE, JIMMY TOAN

PROJECT_TERMS: Age;Antibiotics;Area;Azithromycin;Blindness;Child;Chlamydia;Chlamydia Infections;Chlamydia trachomatis;Clinical;Communities;Confidence Intervals;Country;Data;Decision Making;Diagnostic tests;discontinuation trial;Drops;Early treatment;Europe;Funding;Gambia;Ghana;Goals;Guidelines;Hygiene;Individual;Infection;Inflammation;Intervention;isoniazid;Laos;Low Prevalence;Macrolide-resistance;markov model;Measures;Mexico;Nepal;Niger;population based;Prevalence;programs;Public Health;Randomized;randomized placebo controlled trial;Randomized, Controlled Trials;Recommendation;Recrudescences;Residual state;Resources;response;Sanitation;Savings;serological marker;Seroprevalences;Surveys;Testing;tool;Trachoma;transmission process;treatment response;Uganda;Uveitis;Water;World Health Organization

PROJECT_TITLE: Azithromycin Reduction to Reach Elimination of Trachoma


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Cardiovascular;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Neurodegenerative;Neurosciences;Nutrition;Prevention;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

PI_NAMEs: MARTENS, CHRISTOPHER  (contact)

PROJECT_TERMS: abeta deposition;Adipose tissue;Adult;age related;age related chronic disease;Age-associated memory impairment;Aging;Alzheimer's Disease;Alzheimer's disease risk;Aorta;arterial stiffness;Arteries;Attenuated;Blood;Blood Pressure;blood pressure elevation;Blood Vessels;Brain;brain health;brain tissue;Buffers;cardiometabolic risk;Cardiovascular Diseases;cardiovascular health;Cardiovascular Physiology;cardiovascular risk factor;Carotid Arteries;Centers of Research Excellence;cerebral hypoperfusion;cerebrovascular;Cerebrovascular Circulation;Cerebrovascular Disorders;cerebrovascular reactivity;Cerebrovascular system;Clinical;Cognitive aging;Consumption;Cross-Over Studies;Data;Dementia;Development;Diet;Dietary intake;Elasticity;Endothelium;Energy Intake;Energy-Generating Resources;Environmental Risk Factor;feeding;Food;Fructose;Functional disorder;Future;Glucose;Glycogen;Habits;Health;Health Policy;Heart;high risk;Hippocampus;Hour;Human;Hypercapnia;Hypertension;Hypertriglyceridemia;Impairment;Inflammation;Ingestion;Intake;Life Style;Link;lipid biosynthesis;Liver;Magnetic Resonance Elastography;Measures;Mediating;Memory;Memory impairment;Memory Loss;memory recall;middle age;Modeling;Morbidity - disease rate;mortality;Nerve Degeneration;neuron loss;Neurons;nutritional guideline;older adult;Outcome;Oxidative Stress;Pathologic;Pathology;Performance;Plasma;Preparation;pressure;Process;Public Health;Randomized;Randomized, Controlled Trials;Risk Factors;Risk Reduction;Serum;Single-Blind Study;Structure;sugar;Sweetening Agents;systemic inflammatory response;Testing;Tissues;transmission process;Triglycerides;ultrasound;United States;United States National Institutes of Health;Very low density lipoprotein;very low density lipoprotein triglyceride;viscoelasticity;western diet

PROJECT_TITLE: The effects of added sugar intake on brain blood flow and hippocampal function in midlife adults


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Genetics;Neurodegenerative;Neurosciences;Rare Diseases

ORG_DEPT: ANATOMY/CELL BIOLOGY

PHR: PROJECT NARRATIVE Hexanucleotide GGGGCC repeat expansion in the C9ORF72 gene is the most frequent cause of two neurodegenerative diseases, Frontotemporal Dementia (FTD) and Amyotrophic Lateral Sclerosis (ALS). Disease mechanisms include loss of C9orf72 function and gain of toxicity from the repeat containing RNAs. This project will determine cell-type-specific toxicity of C9orf72 repeat expansions in FTD and ALS.

PI_NAMEs: JIANG, JIE  (contact)

PROGRAM_OFFICER_NAME: LI, TONG

PROJECT_TERMS: Ablation;Address;age related;Alzheimer's Disease;Antisense Oligonucleotides;Astrocytes;Autopsy;Bacterial Artificial Chromosomes;Behavioral;Biological Assay;C9ORF72;Cause of Death;cell type;Cells;Central Nervous System;Cervical lymph node group;Clinical;Coculture Techniques;Data;Dipeptides;Disease;Frontotemporal Dementia;frontotemporal lobar dementia amyotrophic lateral sclerosis;gain of function;Gene Modified;Genes;Genetic;Genetic Transcription;genome-wide;Human;Immune;Immune response;Immune system;Immunologic Stimulation;Introns;Knockout Mice;loss of function;LoxP-flanked allele;Macrophage;Mediating;Microglia;Modeling;Molecular;Mus;Neurodegenerative Disorders;neuroinflammation;neuron loss;Neurons;neurotoxicity;Oligodendroglia;Pathogenesis;Pathogenicity;Pathologic;Pathology;Pathway interactions;Patients;Phenotype;Play;Production;protein function;Proteins;RNA;RNA-Binding Proteins;Role;Sampling;Signal Transduction;Site;Splenomegaly;Synapses;synergism;Testing;Therapeutic Intervention;tool;Toxic effect;transcriptome;transcriptome sequencing;Transgenic Mice;Translations;Untranslated RNA;Vertebral column;Work

PROJECT_TITLE: Cell-type-specific toxicity of C9orf72 repeat expansions in FTD and ALS

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND-R]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Bioengineering;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Cardiovascular;Cerebrovascular;Dementia;Neurosciences

PI_NAMEs: SLATER, JOHN HUNDLEY (contact)

PROJECT_TERMS: Actins;age related;aging hippocampus;arterial stiffness;Arteries;arteriole;Blood capillaries;Blood Vessels;Brain;brain endothelial cell;Brain Injuries;Bulla;Cadherins;cardiovascular health;Caring;Cause of Death;cell injury;Cell Physiology;Cells;Centers of Research Excellence;cerebral microvasculature;Cerebrum;Cessation of life;Clinical Research;Collagen;Coupled;Dementia;Diameter;disability;E-Selectin;Elasticity;Elastin;Elements;Emotional;Endothelial Cells;endothelial dysfunction;Engineering;ethylene glycol;Etiology;Exposure to;Family;Focal Adhesions;Functional disorder;Heart;hemodynamics;Hydrogels;Hypertension;Impaired cognition;in vitro Model;in vivo;Individual;Induced Neurons;Inflammation;injured;Injury;innovation;insight;Investigation;Lead;Link;Maps;Measurement;Measures;Mediating;Microfluidics;Microvascular Dysfunction;Modeling;Molecular;Nanosphere;Nerve Degeneration;Neurites;Neuronal Dysfunction;Neuronal Injury;Neurons;neurovascular;novel therapeutic intervention;Pathologic;Patients;Periodicity;Permeability;Persons;Physiologic pulse;Play;Population;pressure;Process;Pulsatile Flow;Pulse Pressure;Reactive Oxygen Species;Relaxation;Resolution;Role;shear stress;Symptoms;Synapses;Syndrome;Testing;Thinness;Time;Tissues;United States;Vascular Cell Adhesion Molecule-1

PROJECT_TITLE: Quantifying the Influence of Pathological Hemodynamics on Cerebral Microvascular Dysfunction and Neuronal Injury


NIH_SPENDING_CATS: Bioengineering;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: STANFORD

ORG_DEPT: BIOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative (8 lines) With revised title “Emergent Properties of Complex Systems: From Atoms to Macromolecules; from Humans to Societies” this proposal uses data analysis and simulation to show how fundamental interactions lead to complex emergent behavior. Our half a century of experience on how atomic interactions lead to the complex molecular systems key to human health will be applied to protein structure refinement and ribosome function, two long-standing difficult problems. The scope of the work will be broadened to apply the same philosophical approach to a pressing public health problem: how viral diseases spread. Atoms will be replaced by people, atom type by their mobility, infectivity and recovery rate, and the “interatomic forces” by human interactions. Such ‘atomistic’ simulations are expected to reveal how spread can be controlled.

PI_NAMEs: LEVITT, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: NGUYEN, HAN

PROJECT_TERMS: 2019-nCoV;Accidents;atomic interactions;Behavior;Biology;career;Cessation of life;Collaborations;Community Services;Complex;Computational Biology;computer code;computer framework;Computers;Coronavirus;COVID-19;curve fitting;Data;Data Analyses;deep learning;DNA Structure;drug development;drug discovery;Drug Targeting;Epidemic;experience;fascinate;Future;Gases;Growth;Health;Human;Infection;interdisciplinary approach;Lead;Logistics;macromolecule;Mentors;Modeling;Modernization;Molecular;molecular dynamics;neural network architecture;novel;outreach;particle;Peptides;Performance;Persons;Philosophy;Population;Principal Investigator;Productivity;Property;Protein Conformation;protein structure;Proteins;Public Health;Recovery;Research;respiratory virus;Ribosomes;Sampling;Scientist;simulation;Societies;Structure;System;Techniques;Time;transmission process;Viral;Virus;Virus Diseases;Work;Workplace

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


ORG_CITY: NASHVILLE

ORG_NAME: VETERANS HEALTH ADMINISTRATION

ORG_STATE: TN

PHR: The Department of Veterans Affairs is the largest provider of medical care to people with HIV in the United States. The introduction of effective antiretroviral therapy (ART) for HIV infection has extended survival, but this success has been offset by a rising burden of obesity and type 2 diabetes mellitus in Veterans with HIV. Notably, Veterans with HIV have a higher risk of developing type 2 diabetes compared to HIV-negative Veterans with similar age and body weight, but the reason for this higher risk is not clear. Recent studies show that treated HIV can cause changes in adipose tissue (body fat) that are similar to the changes occurring in obesity, which reduce the ability of adipose tissue to store energy and promote the accumulation of adipocytes (fat cells) infiltrating other organs and tissues such as the liver and skeletal muscle. The goal of this study is to understand if excess accumulation of fat in the skeletal muscle of obese Veterans treated for HIV promotes the development of mitochondrial dysfunction and glucose intolerance, information necessary for therapies to prevent diabetes.

PI_NAMEs: KOETHE, JOHN ;SILVER, HEIDI JAYE (contact)

PROJECT_TERMS: Abdominal Muscles;acylcarnitine;Adipocytes;Adipose tissue;Affect;Age;antiretroviral therapy;ATP Synthesis Pathway;Attention;Benign;Bioenergetics;blood glucose regulation;Body fat;Body mass index;Body Weight;Cardiometabolic Disease;Cardiovascular Diseases;Caring;CD8B1 gene;Clinical assessments;cohort;comorbidity;Complex;Data;Defect;demographics;density;Deposition;Development;Diabetes Mellitus;diabetes risk;diabetic;Disease;Endocrinology;experience;Fatty acid glycerol esters;Foundations;Future;Glucose Intolerance;glucose metabolism;glucose tolerance;Glucose Transporter;glucose uptake;Goals;Health;Healthcare;Hepatic;high risk;HIV;HIV Infections;HIV Seronegativity;Image;impaired glucose tolerance;Impairment;improved;Infiltration;Inflammation;Insulin Resistance;insulin secretion;insulin sensitivity;insulin signaling;Interdisciplinary Study;Intervention;Link;Lipids;Liver;Liver diseases;Medical;Metabolic;Metabolic Diseases;Mitochondria;mitochondrial dysfunction;Modeling;Muscle;Muscle Cells;Muscle Mitochondria;muscle physiology;non-diabetic;Non-Insulin-Dependent Diabetes Mellitus;Nonesterified Fatty Acids;novel;nutrition;Obesity;Organ;Overweight;oxidation;Pathogenesis;Pathologic;Pathology;patient population;Persons;Phenotype;Plasma;Population;prevent;Production;Provider;Race;recruit;Regulation;Research;Research Personnel;Risk;Risk Factors;Risk Reduction;Role;sex;Site;Skeletal Muscle;success;Testing;Time;Tissues;Triglycerides;United States;United States Department of Veterans Affairs;Veterans;Veterans Health Administration;X-Ray Computed Tomography

PROJECT_TITLE: Ectopic Lipid in Skeletal Muscle is Associated with Glucose Intolerance in Veterans with HIV


NIH_SPENDING_CATS: Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Cardiovascular;Childhood Obesity;Clinical Research;Heart Disease;Nutrition;Obesity;Pediatric;Prevention

PI_NAMEs: ROBSON, SHANNON MARIE (contact)

PROJECT_TERMS: 12 year old;18 year old;5 year old;Academy;Address;Adult;American;American Heart Association;arterial stiffness;Behavior;behavior influence;Behavioral;Blood;blood lipid;Blood Pressure;Blood Vessels;Body mass index;Cardiovascular Diseases;cardiovascular disorder prevention;cardiovascular disorder risk;cardiovascular health;cardiovascular risk factor;Cause of Death;Centers of Research Excellence;Child;Childhood;Cholesterol;Consumption;Data;Development;Diabetes Mellitus;Diet;dietary;Dietary intake;Eating Behavior;efficacy evaluation;Endothelium;Environment;Evaluation;Family;Fasting;feeding;Food;Frequencies;fruits and vegetables;Gatekeeping;Goals;good diet;Health;Health Promotion;Healthy Eating;healthy weight;Heart;Home;Hypertension;improved;improved outcome;Individual;Insulin;Intake;interest;Intervention;Intervention Studies;Life Cycle Stages;Life Style;Life Style Modification;Literature;Maintenance;Measures;Meta-Analysis;Nature;Obesity;obesity prevention;Observational Study;Outcome;Overweight;Parents;Pathogenesis;Pediatrics;Physical activity;physical inactivity;Prevalence;Prevention;Primary Prevention;Process;programs;psychosocial outcome;Randomized;Randomized, Controlled Trials;Research;Risk;Risk Factors;Smoking;Social Environment;social factors;systematic review;Testing;Time;treatment arm;Unhealthy Diet;United States;Weight;Weight maintenance regimen;Work;Youth

PROJECT_TITLE: Family Meals as a Strategy for the Primary Prevention of Cardiovascular Disease in Children


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Dissemination and Implementation Research;Emerging Infectious Diseases;Health Services;Infectious Diseases;Patient Safety;Prevention;Wound Healing and Care

ORG_CITY: HANOVER

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: PROJECT NARRATIVE  Surgical site infections (SSIs) are associated with increased patient morbidity, mortality, and healthcare costs. ESKAPE (Enterococcus, S. aureus, Klebsiella, Acinetobacter, Pseudomonas, and Enterobacter spp.) pathogens are particularly pathogenic because they have increased capacity to acquire resistance and virulence traits. We have proven that a multifaceted program involving improved basic perioperative preventive measures can generate substantial reductions in S. aureus transmission and significant reductions in SSIs (88% reduction as compared to usual care). In this study, we aim to examine the relative effectiveness of each component of this program in controlling ESKAPE transmission and reducing SSIs and to identify an optimal implementation strategy for national dissemination. This work will improve perioperative patient safety for the 51 million patients who undergo surgery each year.

PI_NAMEs: BROWN, JEREMIAH R (contact);LOFTUS, RANDY W;O'MALLEY, ALISTAIR JAMES

PROGRAM_OFFICER_NAME: ERNST, NANCY L

PROJECT_TERMS: Acinetobacter;Address;Admission activity;Affect;Area;Attenuated;attenuation;Awareness;Catheters;Characteristics;cluster randomized design;Colony-forming units;comparative efficacy;comparison intervention;Complex;cost;Cost Analysis;cost effectiveness;Cost Effectiveness Analysis;Cost Savings;Data;Data Collection;Day Surgery;design;Development;Dissemination and Implementation;Effectiveness;effectiveness/implementation hybrid;Eligibility Determination;Enterobacter;Enterococcus;Epidemiology;Evaluation;Event;evidence base;Evidence based intervention;Evidence based program;Feedback;follow-up;Future;genome analysis;Hand;Health Care Costs;high risk;Hospitalization;Hospitals;Hygiene;implementation strategy;improved;Incidence;incremental cost;Infection;Infection prevention;Institution;Intensive Care Units;Intervention;Investments;Klebsiella;Knowledge;Link;Maintenance;Measures;Methods;Morbidity - disease rate;mortality;mortality risk;multidisciplinary;operation;Operative Surgical Procedures;Outcome;pathogen;Pathogenicity;Patient Care;patient safety;Patients;Perioperative;Phase;post implementation;prevent;Prevention strategy;Preventive measure;programs;prospective;Provider;Pseudomonas;Quality of Care;Randomized;randomized trial;Reach, Effectiveness, Adoption, Implementation, and Maintenance;relative effectiveness;Research;Resistance;Risk;Sampling;scale up;Scientific Advances and Accomplishments;Site;Staphylococcus aureus;Surface;Surgical Specialties;Surgical Wound Infection;trait;Translating;transmission process;treatment as usual;Validation;Virulence;Work

PROJECT_TITLE: The BASIC trial: Improving implementation of evidence-based approaches and surveillance to prevent bacterial transmission and infection

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-Z(02)]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cardiovascular;Clinical Research;Nutrition;Obesity

PI_NAMEs: FANCHER, IBRA  (contact)

PROJECT_TERMS: Adipose tissue;Adult;Affect;Arteries;Automobile Driving;bariatric surgery;Blood flow;Blood Vessels;Cardiovascular Diseases;cardiovascular health;cardiovascular risk factor;Cardiovascular system;career;CD36 gene;Centers of Research Excellence;Ceramides;Complication;Data;Delaware;Development;diet-induced obesity;Economic Burden;Endothelial Cells;endothelial dysfunction;Endothelium;Environment;Epidemic;Exhibits;Fatty Acids;Foundations;Functional disorder;Funding;Gene Expression;Goals;Health;healthcare burden;Human;Hypertension;Impairment;In Vitro;in vivo;inward rectifier potassium channel;Kir2.1 channel;Mediating;mouse model;Mus;Nitric Oxide;Nonesterified Fatty Acids;novel;Obese Mice;Obesity;Obesity associated cardiovascular disease;Outcome;Phase;Phenotype;Population;Positioning Attribute;prevent;Production;Productivity;programs;protein expression;Research;Resources;response;Role;scavenger receptor;subcutaneous;Testing;Thinness;United States National Institutes of Health;Universities;uptake;vascular bed;Vasodilation;Visceral

PROJECT_TITLE: Obesity-Induced Endothelial Dysfunction in Arteries of Visceral Adipose


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: The work in this proposal is aimed at elucidating the basic molecular mechanisms of pathogenesis underlying neurodegenerative diseases that are associated with a genetic anomaly in C9orf72, including amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Although these diseases are becoming an increasingly relevant public health challenge in our aging society, the mechanisms underlying most of these neurodegenerative conditions remain poorly understood. The biochemical, molecular, and genetic studies outlined in this proposal could lead to novel therapeutic interventions for those neurodegenerative diseases, for which effective treatments are still lacking.

PI_NAMEs: WANG, JIOU  (contact)

PROGRAM_OFFICER_NAME: GUBITZ, AMELIE

PROJECT_TERMS: Address;Aging;ALS pathology;Alzheimer's Disease;Amyotrophic Lateral Sclerosis;Autophagocytosis;Biochemical;Biological Models;Brain;c9FTD/ALS;C9ORF72;Caenorhabditis elegans;cell growth regulation;Cells;Clinical;coactivator-associated arginine methyltransferase 1;Defect;Dementia;Disease;effective therapy;epigenetic regulation;Equilibrium;Etiology;familial amyotrophic lateral sclerosis;Feedback;FRAP1 gene;frontal lobe;Frontotemporal Dementia;frontotemporal lobar dementia amyotrophic lateral sclerosis;Genes;Genetic;genetic approach;Genetic study;Goals;Guanosine Triphosphate Phosphohydrolases;Homeostasis;human old age (65+);Huntington Disease;insight;Intervention;Investigation;Knowledge;Link;lipid metabolism;loss of function;Lysosomes;Metabolic;Metabolic Control;Metabolic Pathway;Metabolism;Molecular;Motor Neurons;Mutation;Nerve Degeneration;Neurodegenerative Disorders;neurotoxicity;news;novel;novel strategies;novel therapeutic intervention;Nucleotides;Older Population;Organelles;Pathogenesis;Pathology;Pathway interactions;Patients;Physiological;Play;Predisposition;Proteins;Public Health;Quality Control;Regulation;Research;Role;Signal Transduction;Societies;Spinal Cord;sporadic amyotrophic lateral sclerosis;System;Temporal Lobe;Tissues;tool;Toxic effect;treatment strategy;Untranslated RNA;Work

PROJECT_TITLE: Investigating the role of C9orf72 in autophagic and metabolic dysregulation in ALS/FTD

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


NIH_SPENDING_CATS: Biotechnology

ORG_NAME: ADVANCED SCIENCE RESEARCH CENTER

PHR: RELEVANCE The proposed research will give valuable information into the sensory mechanisms used by PAS and LOV domains, a widespread group of ligand-regulated protein/protein interaction domains used by organisms to sense and respond to changes in their environment. Common structural features of these systems make parallel studies particularly powerful to give insights into a diverse range of biological responses, from how nutrients stimulate human cells and yeast to how bacteria and fungi respond to blue light. Further, this mechanistic information is critical to the development of novel small molecule ligands and “optogenetic” light- regulated protein reagents, giving biomedical researchers new ways to control cellular function with unprecedented precision.

PI_NAMEs: GARDNER, KEVIN H (contact)

PROGRAM_OFFICER_NAME: CHAO, CHIEN-CHUNG

PROJECT_TERMS: Address;adduct;anti-cancer therapeutic;ARNT gene;Attention;Bacteria;Binding;Biochemical;Biological;Biological Assay;Biology;Biomedical Research;Biophysics;Biotechnology;blood glucose regulation;Cell membrane;Cell Physiology;Cells;Characteristics;Chemicals;chromophore;cofactor;Coupled;Coupling;Darkness;Data;detection of nutrient;Development;Disease;DNA Binding;Engineering;Environment;environmental change;Enzymes;Event;experimental study;Family;Family member;Flavins;Foundations;fungus;Gene Expression;Generations;Genetic;Genomics;glucose uptake;Goals;GTP-Binding Protein Regulators;GTP-Binding Proteins;Helix-Turn-Helix Motifs;Human;In Vitro;innovation;insight;Left;Length;Ligands;Light;Lighting;Membrane;Mind;Modeling;Molecular Conformation;Nature;novel;novel therapeutics;Nutrient;optogenetics;Organism;Outcome;Outcomes Research;Output;Oxygen;Pathway interactions;Phosphotransferases;Process;Protein Binding Domain;Protein Conformation;protein function;protein-histidine kinase;Protein-Serine-Threonine Kinases;Proteins;Reagent;recruit;Regulation;Research;Research Personnel;Resolution;response;Route;Sensory;sensory mechanism;Serine;Signal Transduction;Signaling Protein;single-minded protein;small molecule;Stimulus;Structure;success;System;Techniques;Tertiary Protein Structure;Testing;Therapeutic;therapeutic target;tool;transcription factor;voltage;Work;Xenobiotics;Yeasts

PROJECT_TITLE: Structural and mechanistic studies of PAS sensing

STUDY_SECTION: MSFC

STUDY_SECTION_NAME: Macromolecular Structure and Function C Study Section[MSFC]


NIH_SPENDING_CATS: Bioengineering;Brain Disorders;Neurosciences;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE  This project is to study intrinsic and extrinsic regulation of axonal varicosities in the brain induced by mechanical stress. The findings may contribute to the development of a new strategy for treating mild traumatic brain injury and other neurological disorders.

PI_NAMEs: GU, CHEN  (contact)

PROGRAM_OFFICER_NAME: UMANAH, GEORGE KWABENA ESSIEN

PROJECT_TERMS: 3-Dimensional;Acceleration;Adult;Affect;Alleles;Alzheimer's Disease;Autopsy;Axon;axon injury;Behavior;behavior test;Behavioral;behavioral impairment;Binding;Biological Assay;Biomechanics;Brain;Brain Concussion;Brain region;Calmodulin;Calmodulin-Binding Proteins;cell type;Central Nervous System;chronic traumatic encephalopathy;Coculture Techniques;Cognitive;Collaborations;Confocal Microscopy;Corpus Callosum;Cryo-electron tomography;Demyelinations;Development;Diffuse Axonal Injury;Electron Microscopy;Electrophysiology (science);Engineering;Funding;head impact;Heterogeneity;Heterozygote;Image;Imaging Techniques;in vivo;Injury;insight;interdisciplinary approach;Interneurons;knock-down;Knock-out;Knockout Mice;Label;Link;Liquid substance;Location;MAPT gene;Mechanical Stress;Mechanics;Mediating;Methods;Microtubule Depolymerization;Microtubule Stabilization;Microtubule-Associated Protein 2;Microtubule-Associated Proteins;Microtubules;mild traumatic brain injury;Modeling;Morphology;mouse model;Multiple Sclerosis;Mus;Myelin;Nervous System Disorder;Neurons;new therapeutic target;novel;Oligodendroglia;Outcome;overexpression;Pathologic;polypeptide;Process;Property;protein expression;Proteins;Proteomics;Rattus;Recovery;Regulation;Reporting;Research;restraint;Risk;Role;Signal Pathway;Small Interfering RNA;Structure;Swelling;Synaptic Transmission;Tauopathies;Testing;Tissues;Transmission Electron Microscopy;Varicosity;Virus;Visualization

PROJECT_TITLE: Axonal Varicosity Dynamics in Central Neuron Mechanosensation and Injury

STUDY_SECTION: NDPR

STUDY_SECTION_NAME: Neurodifferentiation, Plasticity, Regeneration and Rhythmicity Study Section[NDPR]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

ORG_CITY: FORT COLLINS

ORG_NAME: COLORADO STATE UNIVERSITY

ORG_STATE: CO

PHR: PROJECT NARRATIVE This MARC at CSU program seeks to enhance access of underrepresented students to advanced research training (PhD, MD/PhD, DVM/PhD) and successful careers in biomedical research. This will be achieved by 1) outreach and recruitment of underrepresented, socioeconomically disadvantaged, and disabled undergraduates into the Biomedical Sciences Major; 2) providing a supportive and inclusive environment; 3) providing academic support and laboratory-based research training; and 4) cultivating professional development.

PI_NAMEs: DEAN, GREGG A (contact);QUACKENBUSH, SANDRA L;ZABEL, MARK D

PROGRAM_OFFICER_NAME: AKACEM, LAMEESE DANA

PROJECT_TERMS: Biomedical Research;career;CCL7 gene;cohort;Colorado;Communication;community empowerment;Critical Thinking;Critiques;Decision Making;Degree program;design;Development;Development Plans;diversity and inclusion;Ensure;Environment;evidence base;experience;Faculty;Fellowship;Financial Support;Funding;Goals;Graduation Rates;improved;Individual;laboratory experience;Laboratory Research;Manuscripts;matriculation;meetings;Mentors;Mission;Modeling;Oral;outreach;peer;Population;Process;programs;Publications;Qualifying;Readiness;Research Ethics;Research Institute;Research Training;retention rate;Science;skills;Social Network;Social Sciences;Structure;Student recruitment;Students;success;summer research;Training;Training Activity;Training Programs;Universities;Writing

PROJECT_TITLE: MARC at Colorado State University

STUDY_SECTION_NAME: Training and Workforce Development Study Section - C[TWD-C]


ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

PHR: NARRATIVE (Overall) This project is investigating the human immune responses to infection by and vaccination against three of the most prevalent and devastating global diseases, malaria, HIV-AIDS, and Covid. It is doing so to elucidate detailed characteristics of these immune responses to aid development of needed vaccines and therapeutics.

PI_NAMEs: MCELRATH, MARGARET JULIANA;STUART, KENNETH D (contact);TORGERSON, TROY R

PROGRAM_OFFICER_NAME: PALIN, AMY COLLEEN

PROJECT_TERMS: 2019-nCoV;Adjuvant;Affect;Characteristics;Communicable Diseases;Communities;Data Analyses;data standards;design;Development;Disease;Environmental Exposure;Falciparum Malaria;Foundations;Future;Goals;Health Status;HIV;HIV-1;HIV/AIDS;Human;Human Characteristics;human disease;Immune;Immune response;Immune system;Immunity;Immunization;Immunology;Infection;insight;Institution;Malaria;malaria infection;Molecular Profiling;novel;novel therapeutics;Outcome;pathogen;Persons;Plasmodium falciparum;Population;Predisposition;Prevention;Prevention strategy;Process;Research;Resolution;response;SARS-CoV-2 infection;System;Systems Biology;Technical Expertise;Technology;Therapeutic;treatment strategy;Vaccination;vaccine development;vaccine efficacy;vaccine immunogenicity;vaccine strategy;Vaccines;Variant

PROJECT_TITLE: Immune Responses to Malaria, HIV and SARS-CoV-2 Infection and Immunization


NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Macular Degeneration;Neurodegenerative;Neurosciences

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Abnormal activation of the complement pathway, which regulates innate immunity and inflammation, is associated with blinding diseases such as inherited and age-related macular degenerations. This research will investigate how a novel pathway of intracellular complement activation endangers the health of the retinal pigment epithelium, a key site of insult in macular degenerations. We will study the impact of intracellular complement on the function and integrity of the retinal pigment epithelium, and identify potential points of therapeutic intervention that can be targeted to preserve vision.

PI_NAMEs: LAKKARAJU, APARNA  (contact)

PROGRAM_OFFICER_NAME: SHEN, GRACE L

PROJECT_TERMS: Age related macular degeneration;ATP binding cassette transporter 1;Atrophic;Autophagocytosis;Biogenesis;Blindness;Cell Physiology;Cells;Ceramides;Cholesterol;cholesterol transporters;Chronic;Complement;Complement Activation;complement pathway;complement system;Data;Defect;design;Development;Disease;disease model;Drusen;Early Endosome;Endosomes;Equilibrium;extracellular;Extracellular Space;FRAP1 gene;Functional disorder;Generations;Genes;Genetic Polymorphism;Health;Homeostasis;Human;Image;Inflammation;Inflammatory;Inherited;Injury;innovation;insight;Link;Lipofuscin;live cell imaging;Location;Macular degeneration;Mediating;Metabolic;Metabolism;Mitochondria;Modeling;Molecular;mouse model;Mus;Natural Immunity;novel;Pathogenicity;Pathologic;Pathology;Pathway interactions;Peptide Hydrolases;photoreceptor degeneration;Play;Precision therapeutics;preservation;prevent;Process;programs;Proteolysis;receptor;Receptor Activation;Receptor Inhibition;Receptor Signaling;Recycling;Research;Retina;Retinal Degeneration;Retinal Diseases;Role;Secondary to;segregation;Signal Transduction;Site;Speed;Stress;Structure of retinal pigment epithelium;Swelling;Therapeutic;Therapeutic Intervention;therapeutic target;trafficking;ultra high resolution;uptake;Vision

PROJECT_TITLE: Mechanisms of RPE dysfunction in macular degenerations: role of intracellular complement activation

STUDY_SECTION: DPVS

STUDY_SECTION_NAME: Diseases and Pathophysiology of the Visual System Study Section[DPVS]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Coronaviruses;Emerging Infectious Diseases;HIV/AIDS;Immunization;Infectious Diseases;Malaria;Orphan Drug;Prevention;Rare Diseases;Vaccine Related;Vaccine Related - AIDS;Vector-Borne Diseases

PI_NAMEs: STUART, KENNETH D (contact)

PROJECT_TERMS: Advisory Committees;Budgets;CCL21 gene;Clinical;cohesion;Communication;Consultations;Data Analyses;data management;Educational workshop;Elements;Ensure;experience;Goals;HIV;Immune;Immune response;Immunization;insight;Institution;institutional financing;Intellectual Property;Leadership;Malaria;meetings;member;Monitor;National Institute of Allergy and Infectious Disease;operation;outreach;Periodicals;programs;Publications;Recommendation;Report (document);Reporting;Research;Research Activity;Research Personnel;Research Priority;Research Project Grants;Role;SARS-CoV-2 infection;Schedule;Scientific Evaluation;Services;Site;Subgroup;Supervision;synergism;System;tool;Transcend;Travel;United States National Institutes of Health;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Coronaviruses;Coronaviruses Vaccines;Emerging Infectious Diseases;HIV/AIDS;Immunization;Infectious Diseases;Malaria;Malaria Vaccine;Orphan Drug;Prevention;Rare Diseases;Vaccine Related;Vaccine Related - AIDS;Vector-Borne Diseases

PI_NAMEs: MCELRATH, MARGARET JULIANA (contact)

PROJECT_TERMS: 2019-nCoV;Clinical;clinical infrastructure;Clinical Trials;cohort;Collaborations;Communicable Diseases;design;Doctor of Philosophy;Fred Hutchinson Cancer Research Center;Future;Goals;HIV;HIV-1;Human;Human Subject Research;Immune;Immune response;Immunization;Immunology;Infection;Investigation;Leadership;Malaria;observational cohort study;Observational Study;Prevention;SARS-CoV-2 infection;Specimen;Vaccine Clinical Trial;vaccine trial;Vaccines

PROJECT_TITLE: Immune Responses to Malaria, HIV and SARS-CoV-2 Infection and Immunization - Clinical Core


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Coronaviruses;Data Science;Emerging Infectious Diseases;Genetics;HIV/AIDS;Human Genome;Immunization;Infectious Diseases;Malaria;Orphan Drug;Prevention;Rare Diseases;Vaccine Related;Vaccine Related - AIDS;Vector-Borne Diseases

PI_NAMEs: SKENE, PETER  (contact)

PROJECT_TERMS: 2019-nCoV;ACE2;Antibodies;Antibody Specificity;antigen-specific T cells;Antigens;Avidity;B-cell receptor repertoire sequencing;B-Lymphocytes;Biological;Biological Assay;biological research;Cell Separation;cell type;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Characteristics;cost efficient;Cross-Sectional Studies;cytokine;Cytometry;data ingestion;data integration;data visualization;Deposition;Environment;epigenomics;Evaluation;Flow Cytometry;Gene Expression;Generations;genomic platform;HIV;HIV-1;Human;Immune;Immune response;Immune system;Immunity;Immunization;innovation;Label;Libraries;longitudinal analysis;Malaria;Methods;Modality;Molecular;multiple omics;Myelogenous;pathogen;Peptide/MHC Complex;Peptides;Peripheral Blood Mononuclear Cell;Phenotype;Plasma;Population;Protein Analysis;protein biomarkers;protein expression;Proteomics;receptor;Research;Research Project Grants;Resources;response;Role;Sampling;SARS-CoV-2 infection;Serology;Serology test;Services;single cell sequencing;single-cell RNA sequencing;Sorting;Specificity;Stains;Standardization;System;T cell receptor repertoire sequencing;T-Cell Receptor;transcriptomics;Whole Blood

PROJECT_TITLE: Immune Responses to Malaria, HIV and SARS-CoV-2 Infection and Immunization - Service Core


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Coronaviruses;Coronaviruses Vaccines;Emerging Infectious Diseases;HIV/AIDS;Immunization;Infectious Diseases;Malaria;Malaria Vaccine;Orphan Drug;Prevention;Rare Diseases;Vaccine Related;Vaccine Related - AIDS;Vector-Borne Diseases

PROJECT_TERMS: Adaptive Immune System;adaptive immunity;Affect;Antibodies;Antibody Response;Antigen Receptors;Antigens;Attenuated;B-Lymphocytes;Benchmarking;Biological Assay;Cell Lineage;Cell Physiology;Cells;Characteristics;cytokine;Development;Erythrocytes;Evaluation;Event;Falciparum Malaria;Fingerprint;Future;Generations;Genetic;Genetic Programming;Genetic Transcription;Goals;high dimensionality;HIV;Human;Human Characteristics;Immune;Immune response;Immunity;Immunization;Immunologics;Immunology;improved;Infection;Innate Immune System;insight;Lead;Malaria;malaria infection;Malaria Vaccines;Mediating;Mediator;Methods;Molecular;Monoclonal Antibodies;monocyte;Multiparametric Analysis;multiple omics;Outcome;Pathway interactions;Peptides;Peripheral Blood Mononuclear Cell;Phenotype;Plasmodium falciparum;Population;Process;response;Sampling;SARS-CoV-2 infection;Serum;Signal Transduction;single cell sequencing;Sorting;Sporozoites;Stains;System;Systems Biology;T cell response;T-Lymphocyte;Testing;therapy development;Vaccination;vaccine development;vaccine efficacy;vaccine response;vaccine trial;Vaccines;Variant

PROJECT_TITLE: Scientific Project 1: Malaria Immune Responses to Pre-erythrocytic Malaria Vaccination or Infection


ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative Humans carry enormous gut microbial communities that vary widely between individuals. The microbiome can metabolize chemicals we consume, including food and medical drugs. This research program will identify mechanisms of microbial community variation and define how microbiome composition impacts the metabolism of chemical components of diet.

PI_NAMEs: GOODMAN, ANDREW L (contact)

PROGRAM_OFFICER_NAME: KEANE-MYERS, ANDREA

PROJECT_TERMS: Animal Model;Area;Chemicals;commensal microbes;Consumption;Diet;disorder risk;drug metabolism;Environment;Evolution;Food;Future;Gastrointestinal tract structure;Genes;Genome;Germ-Free;Gnotobiotic;Goals;gut microbiome;gut microbiota;Health;Heterogeneity;host microbiome;Human;Human Biology;Human Genome;Individual;Investigation;Laboratories;Mass Spectrum Analysis;Measures;Mediating;Medical;Metabolism;metabolomics;microbial;microbial community;Microbial Genetics;microbiome;microbiome composition;microbiome research;Molecular;Pharmaceutical Preparations;Phenotype;Process;programs;Research;Shapes;Surveys;treatment response;Variant;Xenobiotics

PROJECT_TITLE: Causes and consequences of interpersonal microbial variation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-S(55)R]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Coronaviruses;Coronaviruses Vaccines;Emerging Infectious Diseases;Genetics;HIV/AIDS;Immunization;Infectious Diseases;Malaria;Malaria Vaccine;Orphan Drug;Prevention;Rare Diseases;Vaccine Related;Vaccine Related - AIDS;Vector-Borne Diseases

PROJECT_TERMS: 2019-nCoV;Acceleration;Acquired Immunodeficiency Syndrome;Active Immunization;adaptive immune response;Adjuvant;Africa;AIDS prevention;analytical tool;Antibodies;Antibody-mediated protection;Antigenic Specificity;Antigens;Architecture;Area;B cell repertoire;B-Lymphocytes;Benchmarking;Biological Assay;Bone Marrow;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cell Physiology;Cells;Circulation;Data Sources;Development;draining lymph node;efficacy trial;Epidemic;Epitopes;Evaluation;Evolution;Formulation;Generations;Goals;Helper-Inducer T-Lymphocyte;HIV;HIV Infections;HIV vaccine;HIV Vaccine Trials Network;HIV-1;HIV/AIDS;Human;Immune;Immune response;Immunity;Immunization;in vivo;Infection;Innate Immune Response;insight;Investigation;Knowledge;Libraries;lymph nodes;Malaria;Measures;Metadata;Molecular;Molecular Profiling;multimodality;neutralizing antibody;novel;Participant;Pathway interactions;Peripheral;Phase;Phenotype;Placebos;Plasma Cells;polyclonal antibody;Population;Population Heterogeneity;prevent;Prevention;Preventive;primary endpoint;Proteomics;Protocols documentation;Regimen;response;Safety;SARS-CoV-2 infection;Serology;Source;study population;success;System;T cell receptor repertoire sequencing;T cell response;T-Cell Immunologic Specificity;T-Cell Receptor;T-Lymphocyte;Technology;Testing;Tissues;Translating;Vaccination;Vaccine Design;vaccine efficacy;vaccine trial;Vaccines;Viral

PROJECT_TITLE: Scientific Project 2: HIV AIDS Defining molecular signatures in humans following vaccination that can inform pathways to protective immunity against HIV-1 infection


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Vaccines;Emerging Infectious Diseases;Genetics;HIV/AIDS;Human Genome;Immunization;Infectious Diseases;Malaria;Orphan Drug;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID;Prevention;Rare Diseases;Vaccine Related;Vaccine Related - AIDS;Vector-Borne Diseases

PI_NAMEs: SZETO, GREGORY LEE (contact)

PROJECT_TERMS: 2019-nCoV;acute COVID-19;acute infection;adaptive immune response;adaptive immunity;Affect;Age;Anti-viral Response;Antibodies;B-Lymphocytes;Biological Assay;Biological Markers;Biological Response Modifiers;burden of illness;CD8-Positive T-Lymphocytes;Cellular Immunity;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Characteristics;Chronic;Clinical;cohort;Convalescence;COVID-19;Cytometry;Data;Diagnostic;Disease;Epitopes;Ethnic Origin;Event;Evolution;Flow Cytometry;flu;follow-up;functional outcomes;Future;Goals;Helper-Inducer T-Lymphocyte;HIV;Human Herpesvirus 4;Humoral Immunities;Immune;Immune response;Immunity;Immunization;Immunologics;improved;Infection;Inflammation;Inflammatory;Innate Immune Response;inter-individual variation;Kinetics;Long COVID;longitudinal analysis;Longitudinal cohort;Malaria;Maps;Molecular;multiple omics;Natural Immunity;new therapeutic target;Outcome;Participant;Pathogenicity;Patients;Peptide/MHC Complex;persistent symptom;Phenotype;Post-Acute Sequelae of SARS-CoV-2 Infection;predictive marker;Prevalence;Prognostic Marker;Proteomics;Race;racial diversity;Recovery;response;RNA vaccine;SARS-CoV-2 immune response;SARS-CoV-2 infection;Serum;severe COVID-19;sex;single cell technology;single-cell RNA sequencing;Site;Subgroup;Symptoms;Syndrome;Systems Biology;T cell receptor repertoire sequencing;T cell response;T-Lymphocyte;Technology;Testing;Therapeutic Intervention;therapeutic target;Time;Vaccination;Vaccine Design;vaccine development;vaccine efficacy;vaccine response;vaccine-induced immunity;Vaccines;Variant;Viral Load result;Viral Respiratory Tract Infection;Virus;Virus Shedding;Work

PROJECT_TITLE: Scientific Project 3: Covid Immune response to SARS-CoV-2 natural infection followed by vaccination


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Coronaviruses;Data Science;Emerging Infectious Diseases;HIV/AIDS;Immunization;Infectious Diseases;Malaria;Networking and Information Technology R&D (NITRD);Prevention;Rare Diseases;Vaccine Related;Vaccine Related - AIDS;Vector-Borne Diseases

PI_NAMEs: GOTTARDO, RAPHAEL  (contact)

PROJECT_TERMS: AIDS Vaccines;Attention;Bioconductor;bioinformatics tool;Biological;Biological Assay;Cells;Cellular Assay;Collaborations;Complex;complex data;Computer Analysis;computerized data processing;computerized tools;Data;Data Analyses;Data Collection;Data Files;data integration;data management;Data Management Resources;data quality;data resource;Data Set;data sharing;data standards;data submission;Databases;Deposition;design;diverse data;Ensure;Fostering;Grant;heterogenous data;high dimensionality;HIV;HIV Vaccine Trials Network;Human;Immune response;Immune system;Immunization;Immunologics;Immunology;Immunology procedure;improved;Infrastructure;insight;Linear Models;Malaria;Measures;Modeling;Noise;novel;open source tool;pathogen;Process;programs;Pythons;Quality Control;Reproducibility;Research;Research Design;Research Project Grants;Resources;response;Sample Size;SARS-CoV-2 infection;Scientist;Secure;Sensitivity and Specificity;Services;Signal Transduction;Standardization;Statistical Data Interpretation;System;Systems Analysis;Systems Biology;Technology;Testing;Tissues;tool;vaccine discovery;vaccine immunogenicity;Vaccines;Visualization;web portal;Work

PROJECT_TITLE: Immune Responses to Malaria, HIV and SARS-CoV-2 Infection and Immunization- Data Management and Analysis Core


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Genetics;Health Effects of Household Energy Combustion;Health Effects of Indoor Air Pollution;Lung;Pediatric;Prevention;Social Determinants of Health

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF GEORGIA

PHR: NARRATIVE Household air pollution resulting from cooking with solid fuels (wood, charcoal, animal dung, coal), the primary household energy source for nearly 3 billion people, is responsible for an estimated 2.3 million premature deaths each year, primarily in low- and middle-income countries. The proposed work leverages the Household Air Pollution Intervention Network (HAPIN) trial in Guatemala to evaluate whether a liquefied petroleum gas (LPG) stove and fuel intervention to reduce this harmful exposure during early life (pregnancy and infancy) improves children’s lung function development and reduces respiratory disease episodes beyond the intervention period and until age 7 years, while exploring epigenetic biomarkers as research tools to understand the biological mechanism of effect. The proposed work will impact health and household energy policies by providing rigorous and generalizable insight to questions regarding the impact of air pollution exposure in early life on respiratory health later in childhood using a scalable household intervention.

PI_NAMEs: MCCRACKEN, JOHN PATRICK (contact)

PROGRAM_OFFICER_NAME: LU, QING

PROJECT_TERMS: 1 year old;2 year old;3 year old;7 year old;Address;Adopted;Adult;Age;Air Pollution;ambient air pollution;Animals;Area;attributable mortality;Biogenesis;Biological;Biological Markers;Blood;burden of illness;Carbon Black;Cessation of life;Charcoal;Child;Childhood;Chronic;Chronic Disease;clinical diagnosis;Coal;cohort;cooking;Detection;Development;disease diagnosis;disorder prevention;DNA Methylation;Dryness;early childhood;early life exposure;Effectiveness;Energy-Generating Resources;environmental tobacco smoke;Epidemiology;epigenetic marker;Epigenetic Process;Exposure to;fine particles;follow-up;Funding;Gases;Growth;Guatemala;Guatemalan;Health;health data;Heterogeneity;Hospitals;Household;Household Air Pollution;improved;Incidence;infancy;Infant;insight;Intervention;intervention effect;Intervention Trial;Life;low and middle-income countries;low income country;Lung;lung development;Measures;methylation biomarker;methylation pattern;Molecular;Observational Study;Oxygen;Participant;Pattern;Persons;Petroleum;Pneumonia;Policies;Population;post intervention;Predisposition;Pregnancy;premature;prenatal;prenatal exposure;pulmonary function;Randomized;Research;Research Design;respiratory;Respiratory Disease;respiratory health;response;Risk;Risk Assessment;Rural;Severities;solid fuel;Source;Spirometry;Spottings;Techniques;Time;tool;ultrasound;Visit;Wood material;Work

PROJECT_TITLE: Effects of Early Life Exposure to Household Air Pollution on DNA Methylation and Respiratory Disease in Guatemalan Children from the Household Air Pollution Intervention Network (HAPIN) Trial

STUDY_SECTION: CRD

STUDY_SECTION_NAME: Cardiovascular and Respiratory Diseases Study Section[CRD]


NIH_SPENDING_CATS: Biotechnology;Genetic Testing;Genetics;Hematology;Human Genome;Precision Medicine;Prevention;Rare Diseases

ORG_DEPT: GENETICS

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Whole-genome sequencing (WGS) studies of rare diseases typically fail to identify an underlying genetic cause in a majority of enrolled patients. Supplementing WGS with RNA sequencing of multiple blood cell types provides an opportunity for addressing this gap. We will develop approaches for exploiting such data, and apply them to discover new causes of disease in a unique cohort of a thousand rare disease patients, boosting the diagnostic power of genetic testing and broadening access to precision medicine.

PI_NAMEs: TURRO, ERNEST  (contact)

PROGRAM_OFFICER_NAME: GOLDBERG, ILANA GRACE

PROJECT_TERMS: Address;Affect;Allelic Imbalance;Bayesian Method;Biological Assay;Biological Models;Blood;Blood Cells;Blood Platelet Disorders;Blood Platelets;Catalogs;causal variant;CD4 Positive T Lymphocytes;Cell Line;Cell model;cell type;Cells;Classification;Clinical Data;clinical phenotype;cohort;Collection;Data;Data Set;Defect;detection method;Diagnosis;diagnostic value;Disease;disorder risk;DNA Binding;Enhancers;Ensure;Etiology;Event;Exhibits;Exons;experience;Frequencies;General Population;Genes;Genetic;genetic disorder diagnosis;Genetic Predisposition to Disease;genetic testing;genome editing;genome sequencing;Genomics;Genotype-Tissue Expression Project;Hematological Disease;Heterozygote;high dimensionality;Individual;Joints;Knowledge;Logistics;machine learning prediction;Measures;Mediator;Megakaryocytes;Methodology;Methods;Methylation;Modeling;Molecular;Molecular Conformation;monocyte;Mutation;Nature;neutrophil;Nonsense-Mediated Decay;novel;Output;Participant;participant enrollment;Pathogenicity;Pathologic;Pathology;Pathway interactions;Patients;Pattern;Persons;Phenotype;phenotypic data;Plasmids;Population;Population Distributions;precision medicine;Probability;progenitor;programs;Rare Diseases;rare genetic disorder;rare variant;Regulatory Element;Reporter;Reporting;Research;response;Reverse Transcriptase Polymerase Chain Reaction;RNA Sequences;RNA Splicing;RNA Stability;RNA Transport;Sampling;Site;Statistical Methods;Tissues;Transcript;transcriptome;transcriptome sequencing;transcriptomic profiling;Untranslated RNA;Validation;Variant;whole genome;Work

PROJECT_TITLE: Integrative analysis of whole genomes and transcriptomes from multiple cell types in rare disease patients

STUDY_SECTION: GCAT

STUDY_SECTION_NAME: Genomics, Computational Biology and Technology Study Section[GCAT]


NIH_SPENDING_CATS: Neurosciences;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_DEPT: NEUROSCIENCES

PHR: The singular goal of most spinal cord injury (SCI) research programs is to repair the injured spinal cord and restore locomotor function. Unfortunately, restoration of walking is a low priority for most SCI individuals. In addition to impaired mobility, SCI causes slow and steady pathological changes in organ systems throughout the body. Failure to recognize and treat multi-organ system pathology as a standard of care may explain why survival rates have not improved for SCI patients (relative to able-bodied individuals) over the past 30 years. Experiments in this proposal are designed to study SCI as a disease of the entire body and will yield novel data that will ultimately promote recovery of function and quality of life (QoL) after SCI.

PI_NAMEs: POPOVICH, PHILLIP G (contact)

PROGRAM_OFFICER_NAME: BAMBRICK, LINDA LOUISE

PROJECT_TERMS: Adipose tissue;Adrenal Glands;Affect;Anxiety;Atherosclerosis;autonomic reflex;Body System;Brain;Brain Diseases;Brain region;Cells;chronic depression;comorbidity;Coupled;Data;Defect;design;Development;Disease;Dysautonomias;experimental study;Failure;Fatigue;Funding;Goals;Grant;Homeostasis;Human;Immune;Immune System Diseases;Impaired wound healing;Impairment;improved;Individual;Infection;Inflammation;Injury;injury and repair;Life;Liver;Lung;Metabolic;Metabolism;Microscopic;Mobility decline;Muscle;National Institute of Neurological Disorders and Stroke;Neuroimmune;non-alcoholic fatty liver disease;Non-Insulin-Dependent Diabetes Mellitus;novel;Organ;Pathologic;Pathology;programs;Quality of life;Recovery;Recovery of Function;Reflex control;Research;restoration;Skin;Spinal;Spinal cord injury;Spinal cord injury patients;Spleen;standard of care;success;Survival Rate;System;Testing;tool;United States National Institutes of Health;Walking

PROJECT_TITLE: Overcoming Neurogenic “Meta-Inflammation” to Promote Recovery After Spinal Cord Injury