ORG_CITY: RALEIGH

ORG_NAME: NORTH CAROLINA STATE UNIVERSITY RALEIGH

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because isoprenoids are widely used in health and medicine. Engineering biosynthetic routes to isoprenoids could provide general and efficient synthetic methods to valuable new molecules and could ultimately lead to the discovery of new small molecule therapeutics. This research will enhance our understanding of the molecular basis of specificity in complex biochemical systems, expand the known limits and capabilities of directed evolution, and establish synthetic biology and directed evolution as powerful approaches for optimizing access to unnatural isoprenoids.

PI_NAMEs: WILLIAMS, GAVIN J (contact)

PROGRAM_OFFICER_NAME: BOND, MICHELLE RUEFFER

PROJECT_TITLE: Directed Evolution of Isoprenoid Biosynthesis

STUDY_SECTION: SBCB

STUDY_SECTION_NAME: Synthetic and Biological Chemistry B Study Section[SBCB]


ADMINISTERING_IC: EY

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: SEATTLE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOCHEMISTRY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Narrative Retinitis pigmentosa (RP) results in untreatable vision loss and may be caused by deficits in energy metabolism. Efforts to compensate for these deficits have been hampered by a lack of comprehensive data on metabolic changes associated with degeneration. The proposed studies seek to understand these changes and help to guide the development of therapeutics that bypass metabolic deficits in RP.

PI_NAMEs: HASS, DANIEL T (contact)

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: aerobic glycolysis;Affect;Age;beta-Hydroxybutyrate;Blindness;Bypass;Carbon;career development;Carotid Arteries;Catheters;Choroid;Circulation;Citric Acid Cycle;Compensation;Consumption;Cysteine;Cytolysis;Data;Development;Disease;early onset;Educational workshop;Electroretinography;Energy Metabolism;experimental study;Eye;Fatty Acids;Genes;Genetic Diseases;Gluconeogenesis;Glucose;glucose transport;Glutamine;Glycogen;Glycolysis;Goals;Health;Impairment;improved;in vivo;individualized medicine;Infusion procedures;Inherited;inorganic phosphate;Label;Laboratories;Learning;Leucine;Light;Lipids;Malates;Measures;Mediating;Mentors;Metabolic;Metabolic Pathway;Metabolism;meter;Modeling;mouse model;Mus;Mutation;Nature;Operative Surgical Procedures;Optical Coherence Tomography;Palmitates;Palmitic Acids;Pathway interactions;Patients;Pentose Phosphate Cycle Pathway;Phenotype;photoreceptor degeneration;Photoreceptors;Physiological;Positioning Attribute;preservation;prevent;Process;programs;Proline;promote resilience;protein expression;Pyruvate;Research;Research Personnel;response;Retina;Retinitis Pigmentosa;Scientist;skills;Source;Stains;Structure of jugular vein;Structure of retinal pigment epithelium;symposium;Testing;therapeutic development;Thick;Tissues;Training;Work

PROJECT_TITLE: Metabolism during the Progression of Photoreceptor Degeneration


ADMINISTERING_IC: AI

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Infectious Diseases;Lung;Rare Diseases

ORG_CITY: BOISE

ORG_NAME: IDAHO VETERANS RESEARCH / EDUCATION FDN

ORG_STATE: ID

PHR: PROJECT NARRATIVE Human adenovirus (Ad) infection can cause acute lung injury and acute respiratory distress syndrome (ARDS), with few treatment options for infection-induced ARDS that has a fatality rate approaching 40%. The Syrian hamster, Mesocricetus auratus, is permissive for human Ad infection and can be used as a model of Ad-induced ARDS. This proposal will develop immunological reagents specific for hamster cell surface markers expressed on macrophages that will be essential for the comparative study of the effects of wild type Ad14 versus emergent Ad14p1 infection on the inflammatory state to help understand how the Ad14p1 variant induces ARDS and to strengthen the Syrian hamster as a small animal model for other human infectious diseases including SARS- CoV-2.

PI_NAMEs: RADKE, JAY R (contact)

PROGRAM_OFFICER_NAME: DONG, GANG

PROJECT_TERMS: 2019-nCoV;Acute Lung Injury;Acute Respiratory Distress Syndrome;Address;Adenoviruses;Alveolar Macrophages;Alzheimer's disease model;Animal Model;Anti-Inflammatory Agents;Antibodies;Biological;Biological Models;Bronchoalveolar Lavage;Bronchopneumonia;CD80 gene;CD86 gene;Cell surface;Cell Surface Proteins;Cells;Cessation of life;Communicable Diseases;comparative;Comparative Study;Complement;CRISPR/Cas technology;CXCL10 gene;CXCR3 gene;cytokine;data analysis pipeline;Death Rate;Development;Disease;Disease Outbreaks;Ebola;Edema;emerging virus;epidemiology study;Experimental Models;Fatality rate;Flow Cytometry;Gene Expression;gene product;Goals;Hamsters;Hantavirus;Hospital Mortality;Human;human pathogen;IL8 gene;Immune;Immune response;Immunocompetent;Immunologics;immunopathology;immunoregulation;in vivo;Incidence;Infection;Infectious Agent;Inflammation;Inflammatory;Inflammatory Response;Influenza;Innate Immune Response;Interleukin-1 beta;Interleukin-6;Lung;Lung infections;lung injury;Macrophage;Macrophage Activation;Marburgvirus;Measures;Mediating;MERTK gene;Mesocricetus auratus;Methods;Military Personnel;Modeling;Molecular;mortality;Mus;Mutation;Natural Immunity;neutrophil;Neutrophil Infiltration;novel;novel strategies;Pathogenicity;Pathway interactions;permissiveness;Phenotype;Play;Population;Positioning Attribute;Predisposition;Production;protein expression;Proteins;Protocols documentation;Reagent;Reporting;respiratory;response;Sampling;SARS coronavirus;Severities;single-cell RNA sequencing;targeted treatment;Testing;Time;TNF gene;tool;Transgenic Organisms;Trauma;Variant;Viral Genes;Virulent;Virus;virus genetics

PROJECT_TITLE: Development of antibodies to specific cell surface markers to assess macrophage polarization during Adenovirus 14 and 14p1 infection in the Syrian hamster

STUDY_SECTION: III

STUDY_SECTION_NAME: Innate Immunity and Inflammation Study Section[III]


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Huntington's Disease;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: CHAPEL HILL

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative: Developing disease-modifying therapies for neurodegenerative diseases is notoriously diﬃcult and is exacerbated by the lack of accurate statistical models to identify the optimal time for intervention. Here, we will use ﬁve longitudinal datasets of Huntington disease, a genetic neurodegenerative disease, to propose new statistical strategies to accurately estimate the disease course. These strategies can be used to help researchers identify when an experimental therapy could best modify the disease course, and help design a well-powered clinical trial to test that therapy.

PI_NAMEs: GARCIA, TANYA PAMELA (contact)

PROGRAM_OFFICER_NAME: MILLER, DANIEL L

PROJECT_TERMS: Area;Behavioral;clinical diagnosis;Clinical Trials;Clinical Trials Design;Cognitive;cohort;Data;Data Set;design;Disease;Drops;Enrollment;Funding;Genetic;Huntington Disease;improved;Intervention;Investigational Therapies;Joints;Lead;longitudinal dataset;Measurement;Measures;Methods;model building;Modeling;Modification;Motor;Neurodegenerative Disorders;neuroimaging;open source;Patients;prevent;Research Personnel;Science;Scientist;semiparametric;Source Code;Statistical Models;Symptoms;Testing;theories;Time;United States National Institutes of Health;Visit;Work

PROJECT_TITLE: Developing a Robust and Efficient Strategy for Censored Covariates to Improve Clinical Trial Design for Neurodegenerative Diseases

STUDY_SECTION: ASPA

STUDY_SECTION_NAME: Analytics and Statistics for Population Research Panel A Study Section[ASPA]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics

ORG_CITY: STONY BROOK

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

ORG_STATE: NY

PHR: Narrative Cell division is basic function of all living things. Here, we test a novel model of how growth in cell size correctly triggers cell division. The outcome will help us understand and modify diseases of growth, such as cancer, and also, perhaps, of aging.

PI_NAMEs: FUTCHER, BRUCE BRUCE (contact)

PROGRAM_OFFICER_NAME: PHILLIPS, ANDRE W

PROJECT_TERMS: Address;Aging;Biological Assay;Cell Cycle;Cell Cycle Inhibition;Cell division;Cell Enlargement;cell growth;Cell model;Cell Size;Cells;Characteristics;Chromatin;Daughter;differential expression;Disease;DNA;DNA-Binding Proteins;experimental study;falls;G1 Phase;Gene Expression;Genes;Genetic Transcription;Grant;Growth;Homeostasis;inhibitor;Malignant Neoplasms;Mammalian Cell;Measures;Messenger RNA;Modeling;novel;Outcome;prevent;promoter;Proteins;Reporter;System;Testing;Titrations;Transcript;Translations;Variant;Yeasts

PROJECT_TITLE: Scaling of transcript abundance with cell size and the commitment to cell division

STUDY_SECTION: CSRS

STUDY_SECTION_NAME: Cellular Signaling and Regulatory Systems Study Section[CSRS]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Biotechnology;Immunization;Prevention

ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: PUBLIC HEALTH RELEVANCE STATEMENT: Monoclonal antibodies (mAbs) have become the fastest growing class of therapeutics in the past decade and benefit patients suffering from rheumatoid arthritis, multiple sclerosis, asthma, atopic dermatitis, and many other diseases. This project seeks to develop novel methods for studying fundamental properties of mAbs and to enable identification of protein drug candidates that have a smaller chance of failure in drug development and manufacturing processes. These tools would enhance efficiency in development of much needed protein therapeutics which, in turn, leads to addressing more of the unmet medical needs.

PI_NAMEs: NEJADNIK, REZA  (contact)

PROGRAM_OFFICER_NAME: CASTLEMAN, MORIAH JOVITA

PROJECT_TERMS: Acceleration;Address;Adsorption;Area;Asthma;Atopic Dermatitis;Behavior;Biological Products;Buffers;candidate identification;Characteristics;cost;Data;Development;Diffusion;Disease;drug candidate;drug development;drug discovery;Drug Formulations;Early identification;Equilibrium;Excipients;Excision;Exclusion;Failure;Formulation;Goals;improved;improved outcome;Ionic Strengths;manufacturability;manufacturing process;Measurement;Measures;Medical;Methods;Modeling;Monoclonal Antibodies;Multiple Sclerosis;novel;Outcome;Patients;Pharmaceutical Preparations;Phase;Predisposition;prevent;Process;Property;Protein Analysis;Proteins;public health relevance;Quartz;Rationalization;Research;research and development;Resources;Rheumatoid Arthritis;Safety;Self Assessment;small molecule therapeutics;Solid;Specific qualifier value;success;Surface;Testing;Therapeutic;therapeutic development;Therapeutic Monoclonal Antibodies;therapeutic protein;tool;Viscosity

PROJECT_TITLE: Assessment of self-association of monoclonal antibody molecules by analysis of the protein layer detected at the proximity of a solid surface

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]


NIH_SPENDING_CATS: Biotechnology;Estrogen;Genetics;HIV/AIDS;Immunization;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS;Women's Health Research

ORG_CITY: DURHAM

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: DUKE UNIVERSITY

PHR: Project Narrative Men and women differ in their immune responses to vaccination, with women mounting stronger reactions but suffering from higher incidences of adverse effects. In transgender individuals undergoing gender-affirming hormone therapy, it is unclear to what extent hormone treatment impacts immune responsiveness to vaccination. To understand the effects of feminizing sex hormone therapy on vaccination, we propose to develop a mouse model of gender-affirming hormone therapy, assess its relevance to human medicine through singe-cell transcriptome studies, and test the immune responses of “cis” vs. “trans” mice to a HIV vaccine.

PI_NAMEs: CAIN, DEREK WILSON (contact)

PROGRAM_OFFICER_NAME: DANG, QUE

PROJECT_TERMS: adaptive immunity;Address;Adjuvant;Adverse effects;adverse outcome;aluminum sulfate;Animal Model;Anti-androgen Therapy;Antibody Response;Antigens;Autoimmune Diseases;B-Lymphocytes;biological sex;bone;C57BL/6 Mouse;Caring;Case Study;cell type;Cells;cis-female;cis-male;Clinical;comparison control;Consensus;Data Set;design;Development;differential expression;Dose;Estrogens;Exhibits;experimental study;Female;Feminization;gender affirming hormone therapy;gender transition;Gene Expression;Genes;Genetic Transcription;Goals;Gonadal Steroid Hormones;Grant;high risk;HIV;HIV vaccine;HIV-1;Homeostasis;hormone therapy;Hormones;Human;human model;human subject;Immune;Immune response;Immune system;Immunity;Immunize;Immunologic Tests;Immunologics;Immunomodulators;Immunophenotyping;immunoregulation;in vivo;Incidence;Individual;innate immune pathways;innovation;insight;Knock-in Mouse;Knowledge;Lymphoid Tissue;male;Measurement;Medicine;men;mouse model;Mus;Natural Immunity;neutralizing antibody;Peripheral Blood Mononuclear Cell;Persons;Physiology;Population;Reaction;Regimen;reproductive function;response;Serology test;sex;single-cell RNA sequencing;Structure of germinal center of lymph node;Testing;Testosterone;transcriptome;transcriptomics;transgender;Vaccination;Vaccine Adjuvant;vaccine development;vaccine immunogenicity;vaccine response;vaccine-induced antibodies;Vaccines;Woman

PROJECT_TITLE: A Mouse Model to Test the Effects of Gender-affirming Hormone Therapy on HIV Vaccine-induced Immune Responses

STUDY_SECTION: HIVD

STUDY_SECTION_NAME: HIV Immunopathogenesis and Vaccine Development Study Section[HIVD]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Biotechnology;Immunization;Immunotherapy;Infectious Diseases;Lung;Pediatric;Pneumonia;Pneumonia and Influenza

ORG_CITY: Morrisville

ORG_NAME: INHALON BIOPHARMA, INC.

PHR: Project Narrative Early treatments against respiratory syncytial virus (RSV), the leading cause of bronchiolitis and pneumonia in the U.S., are sorely needed. To address this need, Inhalon is advancing IN-002, an inhaled monoclonal antibody therapy against RSV that can be dosed with at-home convenience; based on pre-IND feedback from the FDA, we are currently conducting GLP IND-enabling studies. In this proposal, we seek support to produce, vial, and characterize clinical trial materials of IN-002 via a 500L production run completed in accordance to Good Manufacturing Practice standards, and to prepare and submit an IND to the FDA, both of which represent the final remaining hurdles to advance IN-002 into first-in-human studies.

PI_NAMEs: HUTCHINS, JEFF T (contact)

PROGRAM_OFFICER_NAME: KIM, SONNIE

PROJECT_TERMS: 2019-nCoV;Address;Adult;Affinity;Age;Animal Model;Animals;Anti-viral Agents;Anti-viral Therapy;Antibody Therapy;Award;Back;Binding;Biological Assay;Blood;Bronchiolitis;cell bank;Cell Line;Cells;Cessation of life;Child;Chinese Hamster Ovary Cell;Clinic;Clinical;clinical development;clinical material;Clinical Research;clinical translation;Clinical Trials;cost;Cost Savings;COVID-19;COVID-19 treatment;cross reactivity;Cyclic GMP;Data;Daughter;design;Dose;drug testing;Early treatment;effective therapy;Elderly;Engineering;Epithelium;experience;Fc domain;Feedback;first-in-human;Focal Infection;Formulation;Funding;Goals;Good Manufacturing Process;handheld equipment;healthy volunteer;Home;Hospitalization;Human;human monoclonal antibodies;Immune;Immunocompromised Host;Immunoglobulin G;improved;Infant Mortality;Infection;Inhalation;Intervention;Intramuscular Injections;lamb model;Lung;manufacture;manufacturing run;manufacturing scale-up;minimal risk;Monoclonal Antibodies;Monoclonal Antibody Therapy;Morbidity - disease rate;mortality;Mucins;Mucociliary Clearance;Mucous body substance;Nebulizer;Necrosis;Neonatal;neutralizing monoclonal antibodies;Nose;Palivizumab;Pharmaceutical Preparations;Phase;phase 1 study;Phase Ia Clinical Trial;Phase Ia Trial;Placebos;Pneumonia;Polysaccharides;Population;portability;pre-clinical;pre-Investigational New Drug meeting;premature;prevent;Production;programs;Prophylactic treatment;respiratory;respiratory pathogen;Respiratory syncytial virus;Respiratory Syncytial Virus Infections;Respiratory syncytial virus RSV F proteins;Respiratory System;Risk Reduction;Running;Safety;safety assessment;SARS-CoV-2 antibody;Schedule;Serious Adverse Event;Site;Specimen;Structure of parenchyma of lung;symptom management;Testing;Therapeutic;Tissues;Vial device;vibration;Viral;Viral Load result;Viremia;Virion;virtual;Virus;Work

PROJECT_TITLE: GMP manufacturing and IND Filing of IN-002, a potent inhaled muco-trapping antibody therapy for Respiratory Syncytial Virus


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Complementary and Integrative Health;Digestive Diseases;Genetics;Liver Disease;Neurosciences;Nutrition;Physical Activity;Prevention

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE Caloric restriction and exercise benefit brain health and metabolic health span. This project will test if liver ketone synthesis and neuronal ketone utilization are critical for the benefits of intermittent fasting and exercise on indices of brain health and metabolic health.

PI_NAMEs: CRAWFORD, PETER A (contact);THYFAULT, JOHN P

PROGRAM_OFFICER_NAME: FU, YI-PING

PROJECT_TERMS: 3-hydroxy-3-methylglutaryl-coenzyme A;Address;Adipose tissue;Age Months;Aging;aging brain;Anatomy;Attention;Body Composition;Brain;brain health;Brain region;Caloric Restriction;Carbohydrates;Catabolism;Chronic;Clinical Trials;clinically relevant;Coenzyme A-Transferases;Cognition;Cognitive;cognitive function;diet and exercise;Dissection;Energy Intake;Engineering;Epilepsy;executive function;Exercise;experimental study;Fasting;Fatty acid glycerol esters;feeding;Female;Future;Genetic;genetic manipulation;Genotype;glucose metabolism;Health;healthspan;healthy aging;Hepatic;Hepatocyte;Homeostasis;Human;Impaired cognition;improved;indexing;Individual;innovation;interest;Intermittent fasting;Intervention;Kansas;ketogenesis;ketogenic diet;ketogentic;Ketone Bodies;Ketones;Ketosis;Knock-out;lifestyle intervention;Link;lipid metabolism;Lipolysis;Liver;LoxP-flanked allele;Maintenance;male;Measures;Mediating;Memory;Metabolic;Metabolic Diseases;Metabolic dysfunction;metabolic phenotype;Metabolism;metabolome;middle age;Minnesota;Mitochondria;mode of exercise;Modeling;mouse model;Mus;Nerve Degeneration;Neurons;nonhuman primate;novel;Nutritional;old mice;Outcome;oxidation;Peripheral;Phenotype;Physical Function;physical inactivity;Play;preservation;prevent;Recurrence;Research Personnel;response;Role;Running;sedentary;stable isotope;Starvation;succinyl-coenzyme A;synergism;Testing;therapeutic target;Time-restricted feeding;tool;Tracer;transcriptome;treatment optimization;Unhealthy Diet;Universities;western diet;Work

PROJECT_TITLE: Ketogenic oscillations and neurometabolic healthspan


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Lung;Rare Diseases;Tuberculosis

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: NARRATIVE Mycobacterium tuberculosis (Mtb) infection causes approximately 10 million new cases of tuberculosis (TB) and 1.5 million TB-related deaths each year. In order to develop new and more effective therapies, better understanding of Mtb pathogenesis is required. The proposed studies will provide critical insight into the pathogenesis of TB and the immune requirements for successful control of Mtb infection.

PI_NAMEs: STALLINGS, CHRISTINA LEIGH (contact)

PROGRAM_OFFICER_NAME: EICHELBERG, KATRIN

PROJECT_TERMS: Affect;antimicrobial;Autophagocytosis;Binding;Bronchoalveolar Lavage Fluid;Cell Death Process;cell type;Cells;Cessation of life;Chemicals;Chromatin;Chromatin Structure;Complex;cytokine;Cytoplasmic Granules;Data;Disease;Dissection;DNA;effective therapy;extracellular;Genetic;Growth;Histones;Human;Immune;Immune response;improved;In Vitro;in vivo;Infection;Infection Control;Inflammation;insight;Interferon Type I;Internet;Link;Lung;Lysosomes;Macrophage;Mediating;Mus;Mycobacterium tuberculosis;neutrophil;nonhuman primate;Nutrient;pathogen;Pathogenesis;Pathology;Pathway interactions;Patients;Peptide Hydrolases;Phagocytosis;Phagosomes;Predisposition;Process;Production;Protein-arginine deiminase;Proteins;Reaction;Resected;response;Role;Severity of illness;Signal Transduction;Sputum;Structure of parenchyma of lung;Tissues;trafficking;Tuberculosis;tuberculosis treatment;Vesicle;vesicular release

PROJECT_TITLE: Targeting NETosis for the Treatment of Tuberculosis

STUDY_SECTION: BHI

STUDY_SECTION_NAME: Bacterial-Host Interactions Study Section [BHI]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences

ORG_CITY: La Jolla

ORG_NAME: SALK INSTITUTE FOR BIOLOGICAL STUDIES

ORG_STATE: CA

PHR: Narratives The long-term goal of this project is to elucidate multimodal mechanisms underlying selective vulnerability of neuronal and non-neuronal cells to proteinopathies during progression of Alzheimer's Disease (AD). The data from this project will provide novel insights on the types of neurons and glia vulnerable to degeneration and/or alterations of molecular/signaling signature networks in a spatial and temporal fashion and the correlation with neuropathology and cognitive impairment. This approach is a major step toward establishing multiscale models that will help to fill the gap between the effects of genetic variants (e.g., APP, APOE or TREM2) and proteinopathies on brain topology with molecular networks in AD.

PI_NAMEs: LEE, KUO-FEN  (contact)

PROGRAM_OFFICER_NAME: GRAY, ERIN EMILY

PROJECT_TERMS: Age;age difference;Alzheimer's Disease;Alzheimer's disease risk;Amyloid beta-Protein;Astrocytes;Atlases;Bar Codes;Biological Markers;Brain;BRAIN initiative;Brain region;Cell Nucleus;cell type;Cells;Censuses;Cerebellum;Clinical;clinical diagnosis;Complex;Data;Data Set;Detection;differential expression;Disease Progression;Electrophysiology (science);entorhinal cortex;epigenomics;Event;excitatory neuron;Female;Fluorescent in Situ Hybridization;gene network;Genes;genetic variant;Goals;Hippocampus;Human;Impaired cognition;Impairment;inhibitory neuron;insight;Knock-in;Knock-in Mouse;locus ceruleus structure;male;Maps;Memory impairment;Microglia;Molecular;Molecular Profiling;multi-scale modeling;multimodality;multiple omics;Mus;Mutate;Neocortex;nerve supply;Neurobehavioral Manifestations;Neurodegenerative Disorders;Neurofibrillary Tangles;Neuroglia;neuron loss;Neurons;neuropathology;Norepinephrine;novel;Oligodendroglia;Pathogenesis;Pattern;Phase;Physiological;Play;Population;pre-clinical;Predisposition;Prefrontal Cortex;prepulse inhibition;prodromal Alzheimer's disease;promoter;Property;Resolution;response;risk variant;Role;Series;sex;Signal Transduction;single nucleus RNA-sequencing;Slice;Source;spatiotemporal;Staging;tau Proteins;tau-1;Tauopathies;Time;transcriptome sequencing;transcriptomics;TREM2 gene

PROJECT_TITLE: Atlas for neuronal and glial cell types selectively vulnerable to proteinopathies during progression of Alzheimer's Disease


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Diabetes;Nutrition;Obesity

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative The proposed research is relevant to public health because a detailed understanding of the mechanisms regulating insulin receptor signaling and insulin sensitivity can identify new therapeutic targets that can be manipulated for the treatment of diabetes. Therefore, the proposed studies are relevant to the NIH mission to seek fundamental knowledge about the nature and behavior of living systems with the goal of using that knowledge to enhance health, lengthen life, and reduce illness and disability.

PI_NAMEs: ATABAI, KAMRAN  (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: absorption;Acceleration;Acute;Back;Behavior;Binding;Biological;Cardiovascular Diseases;cardiovascular risk factor;Cell membrane;Cell secretion;Cell surface;Cell Surface Receptors;Cells;Complex;Coupled;Data;design;Development;Diabetes Mellitus;diet-induced obesity;Dietary Fats;disability;Endoplasmic Reticulum;Environment;Epidermal Growth Factor;Family;Fatty Acids;Feeds;Glucose Transporter;glucose uptake;Goals;Golgi Apparatus;Grant;Health;improved;innovation;Insulin;Insulin Receptor;insulin receptor substrate 1 protein;insulin regulation;Insulin Resistance;insulin sensitivity;insulin signaling;Integrin alphaV;Integrins;Knowledge;Life;Ligands;Mediating;Metabolic Pathway;milk fat globule;Mission;Morbidity - disease rate;mortality;mouse model;Movement;Mus;Nature;new therapeutic target;novel therapeutics;Obesity;Obesity Epidemic;Organism;Outcome;Pathway interactions;Phosphoric Monoester Hydrolases;Physiological;Prevalence;Process;Protein Dephosphorylation;PTPN1 gene;Public Health;Publishing;receptor;Receptor Signaling;Research;Role;Signal Transduction;Skeletal Muscle;Testing;Therapeutic;translational impact;Tyrosine Phosphorylation;United States National Institutes of Health;uptake;Work

PROJECT_TITLE: Integrin regulation of insulin sensitivity

STUDY_SECTION: SMEP

STUDY_SECTION_NAME: Skeletal Muscle and Exercise Physiology Study Section[SMEP]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Cardiovascular;Cerebrovascular;Dementia;Genetic Testing;Genetics;Neurodegenerative;Neurosciences;Prevention;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: PHOENIX

ORG_NAME: BANNER HEALTH

ORG_STATE: AZ

PHR: Narrative Since cardiovascular disease and Alzheimer's disease (AD) share many of the same risk factors, it is possible that vascular factors play a role in the early development of AD pathology. As the treatment and research paradigms for AD have shifted toward prevention in cognitively unimpaired individuals, there is a need to identify factors that may underlie the pathological hallmarks of AD and vascular markers may serve as viable markers and treatment targets in these new paradigms.

PI_NAMEs: MALEK-AHMADI, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: BENNANI-BAITI, MICHAEL

PROJECT_TERMS: Abeta clearance;Address;Affect;Age;Alleles;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's Disease Pathway;Alzheimer's disease related dementia;Alzheimer's disease risk;Amyloid;Amyloid deposition;apolipoprotein E-4;Arizona;Blood Vessels;Brain-Derived Neurotrophic Factor;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular effects;cardiovascular risk factor;Cardiovascular system;carrier status;Cholesterol;Clinical;Cognition;Cognitive;cohort;Collaborations;Data;Deposition;Development;Disease;Education;Epidemiology;epidemiology study;Event;Family member;gene interaction;Genes;Genetic Markers;Genetic Polymorphism;genetic risk factor;genomic data;Genomics;Genotype;Goals;Homocysteine;Hypertension;Image;in vivo;Individual;Inflammation;interest;Investigation;Kinesin;Link;Measurement;Measures;Mediating;Methylenetetrahydrofolate reductase (NADPH);Nature;Neurofibrillary Tangles;neuroimaging;neuropathology;Non-Insulin-Dependent Diabetes Mellitus;older adult;Outcome;Pathogenesis;Pathologic;Pathology;Pathway interactions;Positioning Attribute;Positron-Emission Tomography;pre-clinical;Predisposition;Prevention;protective effect;protective factors;Publications;Publishing;Recording of previous events;Reporting;Research;Research Project Summaries;Risk;Risk Factors;Role;sex;Source;Specificity;Standardization;tau Proteins;Therapeutic;trend;Vascular Endothelial Growth Factors;vascular factor;Work

PROJECT_TITLE: Cardiovascular Genotype and APOE ε4 Carrier Status Interaction Effects on Amyloid Load in Pre-Clinical Alzheimer's Disease

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Patient Safety

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Narrative The overarching goal of the NCI Experimental Therapeutics Clinical Trials Network (ETCTN) is to  enhance and facilitate the efficient and comprehensive conduct of early-phase clinical trials of  NCI Investigation New Drug (IND) agents. The UPMC Hillman Cancer Center (HCC) proposes to  be a member of the NCI ETCTN as the Pittsburgh Cancer Consortium (PCC) Lead Academic  Organization in a consortium with the University of Florida Health Cancer Center (UFHCC) and  the Albert Einstein Cancer Center (AECC). The mission of the PCC is to create a unified,  integrated clinical trials network that will allow for more seamless advancement and progress of  novel experimental agents and/or combinations through early stages of drug development. The  long-term goal is to guide the development and conduct of early-phase clinical trials that may  have the potential to change the standard of cancer care in the U.S. and worldwide.

PI_NAMEs: BYRD, JOHN C.;DAYYANI, FARSHID ;LUKE, JASON JOHN;VILLARUZ, LIZA COSCA (contact)

PROGRAM_OFFICER_NAME: IVY, S PERCY

PROJECT_TERMS: Acceleration;Adult;Albert Einstein Cancer Center;anti-cancer research;Antineoplastic Agents;appropriate dose;Biological Markers;cancer care;Cancer Center;Cancer Patient;cancer therapy;Cancer Therapy Evaluation Program;Catchment Area;Characteristics;Clinical;clinical development;Clinical Drug Development;Clinical Trials;Clinical Trials Network;Comprehensive Cancer Center;Conduct Clinical Trials;Development;drug development;Drug Kinetics;early phase clinical trial;Early Therapeutic-Clinical Trials Network;Enrollment;experience;Florida;Goals;Health;Infrastructure;Institution;interest;Investigation;Investigational Therapies;Lead;Leadership;Malignant Neoplasms;member;Mission;Molecular;National Cancer Institute;novel;novel therapeutics;Patients;Pennsylvania;Pharmaceutical Preparations;Phase;phase I trial;Phase II Clinical Trials;phase II trial;Process;Productivity;Program Development;programs;Regimen;response;Series;Therapeutic Agents;Toxic effect;tumor;Universities;University of Pittsburgh Cancer Institute;Work

PROJECT_TITLE: NCI ETCTN Pittsburgh Cancer Consortium (PCC)


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Asthma;Lung

ORG_CITY: PHILADELPHIA

ORG_NAME: THOMAS JEFFERSON UNIVERSITY

PHR: Narrative  Current strategies towards reversing bronchoconstriction in asthmatics are suboptimal in their coverage. We propose a novel approach of targeting a mitochondrial protein, TSPO, to promote reversal or inhibition of bronchoconstriction. This proposal will help establish the fundamental link between mitochondrial biology to airway smooth muscle contractile function that could lead to a novel approach for managing asthma.

PI_NAMEs: NAYAK, AJAY  (contact)

PROGRAM_OFFICER_NAME: LU, JINING

PROJECT_TERMS: Actins;Adrenal Cortex Hormones;Agonist;airway inflammation;airway remodeling;antagonist;Anti-Inflammatory Agents;Architecture;Asthma;asthmatic;asthmatic patient;Basic Science;Benzodiazepine Receptor;Benzodiazepines;Binding;Biological Models;Biological Response Modifier Therapy;Biology;Bronchoconstriction;Bronchodilation;Bronchodilator Agents;Cavia;Cell model;Cells;Contracts;Coupling;CRISPR/Cas technology;Cyclic AMP;Cyclic AMP-Dependent Protein Kinases;Cytoskeleton;design;Development;drug development;druggable target;Event;G Actin;G-Protein-Coupled Receptors;Goals;GPR68 gene;Health Care Costs;Homeostasis;Human;improved;In Vitro;in vivo;in vivo evaluation;in vivo Model;Individual;innovation;insight;knock-down;Knockout Mice;Ligands;Link;Lorazepam;Lung;Maintenance;Mediating;Methodology;Mitochondria;Mitochondrial Membrane Protein;Mitochondrial Proteins;Modeling;molecular modeling;Mus;Muscle;Muscle Contraction;Muscle relaxation phase;myosin phosphatase;Myosin Regulatory Light Chains;neurosteroids;novel;novel strategies;novel therapeutics;Obstructive Lung Diseases;Peripheral;Pharmaceutical Preparations;pharmacologic;Phosphorylation;polymerization;Polymers;prevent;Property;protein activation;Proteins;Protons;Reactive Oxygen Species;Regulation;Relaxation;respiratory smooth muscle;Role;Safety;Signal Transduction;Slice;Small Interfering RNA;Smooth Muscle;Smooth Muscle Myocytes;Specificity;Stimulus;Structure;System;Testing;Therapeutic;therapeutic target;Tissue Model;Tissues;tool;Trachea;Traction;United States;virtual

PROJECT_TITLE: Mitochondrial translocator protein: a target for bronchodilation

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: The long term public health goal of the proposal is to use our recent discovery about how genes are silenced to enhance the development of stem cell-derived pancreatic beta cells for use as curative transplants into humans with type I diabetes. Currently, making beta cells from human embryonic stem cells is inconsistent and results in beta-like cells in an immature state. We discovered a mechanism of gene silencing that appears to be dysregulated in stem cell-derived beta-like cells, and we propose to modulate the silencing process to generate properly functioning beta cells.

PI_NAMEs: ZARET, KENNETH  (contact)

PROGRAM_OFFICER_NAME: HWA, ALBERT J

PROJECT_TERMS: Address;Animals;Autoimmune;Beta Cell;Biological Assay;Birth;Cadaver;Cell Count;cell dedifferentiation;Cell Differentiation process;Cell Maturation;Cell Physiology;Cell Reprogramming;Cell Transplantation;cell type;Cells;Dependence;diabetic;differentiation in vitro;Elements;Embryo;Embryonic Development;endocrine pancreas development;Endoderm;Endoderm Cell;epigenetic memory;Epigenetic Process;Euchromatin;Fibroblasts;Gene Activation;Gene Silencing;Genes;Genetic;Genome;Germ Layers;Glucose;Goals;health goals;Hepatic;Heterochromatin;Human;human embryonic stem cell;Impaired health;improved;In Vitro;in vivo;induced pluripotent stem cell;insight;Insulin;insulin secretion;Insulin-Dependent Diabetes Mellitus;islet;Islets of Langerhans;knock-down;Knockout Mice;Laboratories;laboratory experience;Life Style;Liver;Maps;Medical;Metabolic;Metabolism;Methods;Methyltransferase;mouse development;Mouse Strains;Mus;Organoids;Patients;Physiological;Process;Proteins;Proteomics;Protocols documentation;Public Health;Recovery;Research;Role;Signal Transduction;Stem Cell Development;stem cell differentiation;stem cells;Structure of beta Cell of islet;success;Sucrose;System;Testing;Time;Tissues;Transplantation;type I diabetic;Undifferentiated;zinc finger nuclease

PROJECT_TITLE: Modulating heterochromatin to improve beta cell differentiation from stem cells

STUDY_SECTION: CADO

STUDY_SECTION_NAME: Cellular Aspects of Diabetes and Obesity Study Section[CADO]


ORG_NAME: FRED HUTCHINSON CANCER CENTER

PHR: PROJECT NARRATIVE Defective and damaged proteins are rapidly degraded by a molecular machine called the proteasome. If the proteasome does not function efficiently, this can lead to toxic accumulation of abnormal proteins. This project aims to better understand how cells regulate the proteasome to prevent this from happening. Mis-regulation of the proteasome plays important roles in cancer, neurodegenerative diseases and some rare genetic disorders. In the long-term, our fundamental insights into proteasome regulation will lead to new treatments for these diseases.

PI_NAMEs: LEHRBACH, NICOLAS JOHN (contact)

PROJECT_TERMS: Animals;Biological Assay;Caenorhabditis elegans;Cancerous;Cell Physiology;Cells;Development;Disease;Ensure;Eukaryotic Cell;Failure;genetic approach;Genetic Screening;Health;Human;Hyperactivity;improved;Individual;insight;Intervention;Malignant Neoplasms;Molecular;Molecular Machines;multicatalytic endopeptidase complex;Nerve Degeneration;Neurodegenerative Disorders;novel;pharmacologic;Physiology;Play;Post-Translational Protein Processing;prevent;Proteasome Inhibitor;Protein Biosynthesis;protein degradation;Proteins;Quality Control;rare genetic disorder;Regulation;Reporter;Resistance;Role;Signal Transduction;stressor;trafficking;Work

PROJECT_TITLE: Regulation of Proteasome Capacity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-H(55)R]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Depression;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Serious Mental Illness

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

PHR: Individualized brain biomarkers of late life depression: contributions to heterogeneity and resilience Project narrative About 1 in 10 people aged 60 and over experience depression, which puts them at higher risk for other health problems such as diabetes and stroke. In this proposal we will distinguish brain profiles linked to differences between people in terms of depression symptoms, severity, age of first depression, and number of depressed episodes they experienced. Furthermore, we will identify environmental and psychological stress factors that explain why some older people are more vulnerable or more resilient to depression than others.

PI_NAMEs: BIJSTERBOSCH, JANINE DIANE (contact)

PROGRAM_OFFICER_NAME: LYONS, ELIZABETH ANNE

PROJECT_TERMS: Acute;Address;Adopted;Adult;Age;Age of Onset;aged;allostatic load;Anisotropy;biobank;biological adaptation to stress;Biological Markers;Blood Vessels;Brain;Chronic;Clinical;clinical heterogeneity;cognitive reserve;comparison group;Data;Data Set;Dementia;demographics;Depressed mood;depressive symptoms;Diabetes Mellitus;Diet;environmental stressor;experience;Family;Family history of;follow-up;geriatric depression;gray matter;Health;Heterogeneity;high risk;Hippocampus;human old age (65+);improved;Individual;Individual Differences;individual patient;innovation;Link;Major Depressive Disorder;Maps;Matched Group;Measures;Mental Depression;Mental Health;Modeling;mood symptom;multimodality;Nature;neuromechanism;novel;Older Population;Outcome;Patients;pediatric trauma;Persons;Physical Exercise;Population;predictive modeling;Prevention;Process;promote resilience;Psychiatry;Psychological Stress;psychological stressor;Public Health;Recording of previous events;Regression Analysis;Reporting;Research;resilience;resilience factor;Rest;Risk;Sampling;Scanning;Severities;Social support;Stress;stressor;Stroke;Symptoms;Testing;theories;Thick;Time;Training;trait;Trauma;treatment strategy;Validation;White Matter Hyperintensity

STUDY_SECTION: BGES

STUDY_SECTION_NAME: Behavioral Genetics and Epidemiology Study Section[BGES]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: NEW YORK

ORG_DEPT: PHYSIOLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative The goal of this training grant is to provide support and specialized training to highly motivated predoctoral and postdoctoral researchers in the field of endocrinology and related subjects dealing with all aspects of hormone biology at the organ, cellular, molecular levels using modern genetic tools in various model organisms and human subjects. The program capitalizes on the outstanding environment of 30 basic and clinical science researchers representing seven Columbia University departments.

PI_NAMEs: KOUSTENI, STAVROULA  (contact)

PROJECT_TERMS: Hormones;Molecular Mechanisms of Action

PROJECT_TITLE: Hormones: Molecular Mechanism of Action and Functions

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_DEPT: GENETICS

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Project Narrative - This proposal aims to develop novel molecular network based drug repositioning approaches to identify FDA approved drugs and their combinations that can potentially reverse molecular signatures and network states of Alzheimer's disease (AD) derived from large-scale bulk-tissue and single cell transcriptomic data in AD. A number of predicted drugs and drug combinations will be validated using multiple model systems including mouse primary brain cells, human iPSC derived brain cells and AD mouse models.

PI_NAMEs: BRENNAND, KRISTEN JENNIFER;CAI, DONGMING ;ZHANG, BIN  (contact)

PROGRAM_OFFICER_NAME: ARUNKUMAR, NANDINI

PROJECT_TERMS: Acceleration;Accounting;Affect;Alzheimer's Disease;Alzheimer's disease therapy;Animal Disease Models;Binding;Biological Models;Biology;Brain;brain cell;Cells;Chronic;Clinic;Clinical;Clinical Data;clinical phenotype;cognitive ability;Data;Databases;Dementia;design;Development;differential expression;Disease;Drug Combinations;drug development;drug discovery;drug efficacy;drug repurposing;efficacy evaluation;efficacy testing;efficacy validation;Epigenetic Process;experimental study;FDA approved;Genetic;Healthcare Systems;high dimensionality;human induced pluripotent stem cells;In Vitro;in vivo;Individual;induced pluripotent stem cell;innovation;Investigation;Late Onset Alzheimer Disease;Medicine;Memory Loss;Modeling;Molecular;molecular phenotype;Molecular Profiling;mouse model;Multiomic Data;Mus;network models;Network-based;Neurodegenerative Disorders;neuropathology;novel;novel therapeutics;Outcome;Pathogenesis;Pathogenicity;Pathologic;Pathway interactions;Pharmaceutical Preparations;Pharmacotherapy;Phenotype;Play;Positioning Attribute;Process;Proteomics;Regulation;Role;Sampling;Structure;Symptoms;System;Systems Biology;Testing;Therapeutic Intervention;Therapeutic Research;Tissues;transcriptomics;Treatment Efficacy

PROJECT_TITLE: Novel Network Biology Approaches to Reposition FDA-approved Drugs for Alzheimer's Disease


ADMINISTERING_IC: TR

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Social Determinants of Health

ORG_CITY: WORCESTER

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

ORG_STATE: MA

PHR: PROJECT NARRATIVE – O. OVERALL The University of Massachusetts Center for Clinical and Translational Science (UMCCTS) provides innovative education and career development programs, catalytic pilot grant programs, and cost-effective core services that accelerate the translation of discoveries into practical solutions that improve human health. Page 186 Project Narrative

PI_NAMEs: LUZURIAGA, KATHERINE F (contact)

PROGRAM_OFFICER_NAME: GANNOT, GALLYA

PROJECT_TERMS: Abbreviations;Acceleration;Address;Advanced Development;Biological Products;Boston;Career Choice;career development;Childhood;Clinical;clinical center;Clinical Research;Clinical Sciences;clinical trial recruitment;Clinical Trials;Collaborations;commercialization;Communities;community collaboration;community engagement;Community Health;Competence;Complex;Consultations;cost effective;cultural competence;Data;data lake;Data Science;Decision Making;Development;Device or Instrument Development;didactic education;digital;Disparity population;Education;Elderly;Engineering;Ensure;Entrepreneurship;Environment;Evaluation;evidence base;first-in-human;flexibility;Fostering;Foundations;Funding;Future;Goals;Grant;Health;health care delivery;health equity;Health system;Healthcare;hearing impairment;Human;improved;Individual;Industry;Informatics;innovation;insight;Institution;interoperability;Knowledge;Learning;Life;life span;literacy;Massachusetts;Medical Device;medical schools;member;Mentorship;Methods;Modeling;Multi-Institutional Clinical Trial;National Center for Advancing Translational Sciences;new product development;next generation;novel;novel strategies;Operations Research;Participant;participant enrollment;Patient Care;Patients;Performance;Point of Care Technology;population health;Privacy;Process;Professional Practice;Program Development;programs;recruit;Research;Research Personnel;Research Support;Resources;Safety;safety net;Science;Security;Services;simulation;skills;Speed;success;System;Technology;Testing;Training;Training Programs;Translating;Translation Process;translational impact;translational pipeline;Translational Research;translational research program;Translations;Underrepresented Populations;Underserved Population;United States National Institutes of Health;Universities;Vision;Workforce Development


NIH_SPENDING_CATS: Atherosclerosis;Biomedical Imaging;Cardiovascular;Clinical Research;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE: Cardiac chest pain is often caused by a severe blockage of a major heart (coronary) artery. In some cases of chest pain, all coronary arteries are “open” and the pain may be caused by abnormalities of the microscopic blood vessels of the heart, known as coronary microvascular disease. The proposed research will investigate the role of platelets in the mechanism of coronary microvascular disease and evaluate non-invasive ways to evaluate patients with this diagnosis. 1

PI_NAMEs: SMILOWITZ, NATHANIEL ROSSO (contact)

PROGRAM_OFFICER_NAME: WEBB, STEPHANIE JOHNSON

PROJECT_TERMS: Address;Affect;Angiography;Arteries;Binding;Biological Assay;Blood flow;Blood Platelets;Blood Vessels;Cardiac;Cardiac Catheterization Procedures;cardiac magnetic resonance imaging;Cardiovascular Diseases;Cardiovascular system;Cause of Death;Cells;Chest Pain;Clinical;Clinical Investigator;Clinical Trials;cohort;Coronary;Coronary Angiography;Coronary Arteriosclerosis;Coronary artery;Coronary Vessels;Darkness;Data;density;Diagnosis;Diameter;disability;disease diagnosis;Distal;Educational Curriculum;endothelial dysfunction;Endothelium;Enrollment;Evaluation;Event;Foundations;Future;Glycocalyx;Heart;Heart failure;Image;Impairment;in vivo;indexing;Inflammatory;insight;Investigation;Ischemia;Leukocytes;light transmission;Measurement;Measures;Mediating;men;Mentorship;Microcirculatory Bed;Microscopic;Microvascular Dysfunction;Modality;monocyte;mortality risk;Myocardial Infarction;Myocardial Ischemia;National Heart, Lung, and Blood Institute;novel;Obstruction;Outcome;Pain;Pathogenesis;Patients;Perfusion;Physiology;Platelet aggregation;Play;Positive Test Result;Positron-Emission Tomography;pressure;Prevalence;Process;Reporting;Research;Resistance;response;Role;Specialized Center;Stenosis;Strategic vision;Stress;Stress Tests;Structure;symposium;Symptoms;Testing;Therapeutic;Thermodilution;Time;Training;translational scientist;United States;vascular abnormality;vascular bed;Vascular Diseases;Vascular Endothelium;vascular inflammation;Woman

PROJECT_TITLE: Mechanisms of Coronary Microvascular Disease

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(MA)]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences

ORG_DEPT: PSYCHOLOGY

PHR: Project Narrative Discrimination between threatening and non-threatening contexts is an adaptive neurobiological process, whereas traumatic stressors may shift responses toward generalization. This proposal will utilize animal studies to elucidate novel neural pathways and mechanisms important for the consolidation of fear memory strength and precision. Given that over-generalization from a previously traumatic to innocuous context is a core feature in several stress-related psychiatric diseases, information from these studies will establish a novel framework for the development of future interventions for these conditions.

PI_NAMEs: LALUMIERE, RYAN T;RADLEY, JASON J (contact)

PROGRAM_OFFICER_NAME: VICENTIC, ALEKSANDRA

PROJECT_TERMS: Address;Adrenalectomy;Amygdaloid structure;Animals;Area;Avoidance Learning;Binding;Brain;Corticosterone;Data;Dependence;Development;Discrimination;discrimination task;Elements;Event;expectation;experience;experimental study;fear memory;Fright;Future;Glucocorticoid Receptor;Glucocorticoids;Hormonal;Hormones;Human;improved;insight;Intervention;knock-down;Learning;maladaptive behavior;Medial;Mediating;Memory;memory consolidation;Mental disorders;neural;neural circuit;Neural Pathways;neurobiological mechanism;Neurobiology;neuromechanism;Neurons;novel;optogenetics;Organism;Output;Pathway interactions;Play;Prefrontal Cortex;Process;Prosencephalon;Rat Transgene;Receptor Activation;Research;response;Role;Site;Stress;stressor;Structure of terminal stria nuclei of preoptic region;System;Testing;Training;Work

PROJECT_TITLE: Circuit versus stress hormonal influences in consolidation of fear memory strength and precision.

STUDY_SECTION: LMDN

STUDY_SECTION_NAME: Learning, Memory and Decision Neuroscience Study Section[LMDN]


ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: Inflammasome pathways are highly complex, rendering them susceptible to interruption and dysregulation, leading to its association with many human diseases, such as autoinflammatory diseases, and autoimmune diseases. For NLRP1, which expresses highly in human keratinocytes, its germline mutations lead to many skin-related inflammatory diseases with constitutive inflammasome activation and downstream pyroptotic cell death. Both NLRP1 and CARD8 play additional roles in drug-induced cancer cell death. Understanding both pathways at the molecular level would contribute to human health and disease.

PI_NAMEs: WU, HAO  (contact)

PROGRAM_OFFICER_NAME: SINGLETON, KENTNER L

PROJECT_TERMS: Acceleration;Address;anthrax lethal factor;Architecture;Attention;Autoimmune Diseases;autoinflammatory;autoinflammatory diseases;Binding;Biochemical;Biological;Biology;C-terminal;carcinogenesis;CASP1 gene;Caspase;Cell Death;Cellular biology;Characteristics;Chemicals;Color;Complement;Complex;Cryoelectron Microscopy;cytokine;Data;design;Dipeptidyl Peptidases;Disease;Dissociation;Embryonic Development;Experimental Designs;experimental study;Filament;Germ Lines;Germ-Line Mutation;Health;Homeostasis;Human;human disease;Immune signaling;Immunity;Inflammasome;Inflammation;Inflammatory;inhibitor;Interleukin-1 beta;Interruption;keratinocyte;Knock-out;Lead;Length;Leucine-Rich Repeat;Maintenance;marenostrin;Mediating;Modeling;Molecular;Molecular Profiling;multicatalytic endopeptidase complex;Mus;mutant;Mutation;N-terminal;novel;Nucleotides;pathogen;Pathogenicity;Pathologic;Pathway interactions;Pattern recognition receptor;Peptide Hydrolases;Peptides;Pharmaceutical Preparations;Play;Predisposition;Process;Proline;Proteins;recruit;Regulation;Repression;response;Rest;Rodent;Role;sensor;Shigella;Signal Transduction;Signaling Protein;Site;Skin;skin disorder;small molecule inhibitor;Specificity;Stress;Structure;Testing;VDAC1 gene

PROJECT_TITLE: NLRP1 and CARD8 Inflammasomes:  Assembly, Regulation and Stress Sensing

STUDY_SECTION: MSFC

STUDY_SECTION_NAME: Macromolecular Structure and Function C Study Section[MSFC]


NIH_SPENDING_CATS: Genetics;Infectious Diseases;Malaria;Orphan Drug;Rare Diseases;Vector-Borne Diseases

ORG_DEPT: CHEMISTRY

PHR: Project Narrative The asymptomatic liver-stage of Plasmodium infection presents an attractive target for drug and vaccine development to combat malaria. Essential host modulators of parasite liver-stage development, such as aquaporin-3, have been identified and suggest the importance of the host cellular environment to the parasite. This project will investigate the role of aquaporin-3 in Plasmodium infection to advance knowledge regarding parasite-host interactions and aid in the pursuit of novel host-targeting therapeutic strategies.

PI_NAMEs: DERBYSHIRE, EMILY R (contact)

PROGRAM_OFFICER_NAME: MCGUGAN, GLEN C

PROJECT_TERMS: Address;Affect;Affinity;AQP9 gene;aquaporin 3;Binding;Biological;Biological Models;Biology;Blood;cell fixing;Cell membrane;Cells;Chemicals;Chemistry;chemoproteomics;clinically relevant;combat;Complex;Cysteine;Development;Disease;disorder control;drug development;Drug resistance;Drug Targeting;Environment;Erythrocytes;Foundations;functional genomics;Future;Genes;Genetic;genetic approach;Genetic Engineering;Genetic Transcription;global health;Glycerol;Goals;Growth;Hepatocyte;Hour;Human;Image;Imaging Device;Immunoelectron Microscopy;Infection;insight;Integration Host Factors;Invaded;Knowledge;Label;Life Cycle Stages;live cell imaging;Liver;Malaria;malaria infection;Mammalian Cell;Maps;Measures;Membrane;Modeling;Modification;Molecular;Movement;mutant;novel;novel therapeutic intervention;Nutrient;Parasites;pathogen;Permeability;Plasmodium;Plasmodium falciparum;Plasmodium vivax;prevent;Process;programs;prophylactic;Protein Dynamics;Proteins;recruit;Research;Resolution;reverse genetics;Role;Route;screening;small molecule;solute;spatiotemporal;System;targeted treatment;Testing;timeline;tool;trafficking;transcriptomics;transmission process;vaccine development;Vacuole;Vesicle;Visualization;Water;water channel;Work

PROJECT_TITLE: Understanding and Targeting Host Processes Essential to Plasmodium Infection

STUDY_SECTION: PTHE

STUDY_SECTION_NAME: Pathogenic Eukaryotes Study Section[PTHE]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

ORG_CITY: Cincinnati

ORG_NAME: INTERNATIONAL CHEMICAL WORKERS UNION

ORG_STATE: OH

PHR: The ICWUC seeks to continue its national multi union training program to protect a range of collateral duty emergency responders and disaster workers, develop a cadre of worker trainers by using adult education principles and techniques, expand Spanish programs and add two new partners, AFSCME and AOEC.

PI_NAMEs: GLINES-ALLEN, SHARI LYNN (contact)

PROGRAM_OFFICER_NAME: BEARD, SHARON

PROJECT_TERMS: Adult;American;arm;Authorization documentation;Avian Influenza;Awareness;Bibliography;bilingualism;Biological;Black race;Chemicals;Clinic;Collection;Communicable Diseases;Communities;community building;Computer software;Computers;County;course development;Data;Data Sources;design;Development;Disasters;E-learning;Education;Educational Curriculum;Educational Models;Educational process of instructing;Educational Technics;Electronics;Emergency response;emergency service responder;Employee;Evaluation;Exercise;experience;Exposure to;Feedback;Food;Goals;Government;hazard;Health;Health Hazards;Health Professional;Healthcare;Hour;Hurricane;improved;Individual;Industrialization;Infectious Agent;Internet;Intervention;Joints;Knowledge;Latin American;Learning;Link;manufacture;Measles;Measures;member;Methods;Minority;minority communities;Molds;Monitor;Municipalities;National Institute of Environmental Health Sciences;new technology;Occupational;Occupational Health;outreach;Paper;Participant;Poison;preservation;Procedures;Program Development;programs;Public Health;Public Sector;Publishing;Quality Control;recruit;Resources;response;Role;Safety;Schools;Site;skills;Spanish;Surveys;Target Populations;Technical Expertise;Technology;Trainers Training;Training;training data;Training Programs;Universities;volunteer;Wages;Work;Workplace

PROJECT_TITLE: Multi Union National Worker and Worker-Trainer Health and Safety Training program


NIH_SPENDING_CATS: Clinical Research;Emergency Care;Health Services;Infectious Diseases;Prevention

PHR: HWWT Project Narrative The ICWUC seeks to continue its national multi union training program to protect a range of collateral duty emergency responders and develop a cadre of worker trainers. We use a range of adult education principles and techniques that rely on the knowledge and experiences of the participants to teach key principles in a non-threatening and engaging method that motivates trainees to improve their worksites. We will include two new partners, the American Federation of State, County and Municipal Employees (AFSCME) and the Association of Occupational and Environmental Clinics (AOEC) to form a 12-member Consortium. We will continue to develop worker trainers, offer hazmat classes to industrial, health care, government and school workers and work with other NIEHS Grantees.

PROJECT_TERMS: Academy;Adult;American;arm;Awareness;bilingualism;chemical disaster;Chemicals;Clinic;Communicable Diseases;Connecticut;County;course development;Cypress;Data;design;Development;Disease;economic evaluation;Education;Educational Curriculum;Educational Models;Educational process of instructing;Educational Technics;Eligibility Determination;emergency preparedness;Emergency response;emergency service responder;Employee;Engineering;Evaluation;experience;Fire - disasters;First Aid;fitness;Goals;Government;Grant;hazard;Hazard Controls;Hazardous Substances;Health;Health Personnel;Healthcare;high school;Hospitals;Hour;improved;Income;Individual;Industrialization;Internet;Intervention;Joints;Knowledge;Learning;Location;Maintenance;Marketing;meetings;member;Methods;Minority;Molds;Municipalities;National Institute of Environmental Health Sciences;New York City;Occupational;Occupations;outreach;Paper;Participant;Patients;Persons;Physicians;Poison;Police;Procedures;programs;Public Health;Public Sector;Publishing;Quality Control;recruit;Resources;Safety;Schools;science teacher;Secure;Services;simulation;Site;skills;Social Workers;Spanish;Students;Surveys;Trainers Training;Training;training data;Training Programs;Training Support;Universities;Vocation;Wages;Work;Workplace

PROJECT_TITLE: Multi Union National Chemical Emergency Response Training program


NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Prevention

PHR: HDP Project Narrative The ICWUC seeks to continue its disaster response programs (in Spanish and English) to prepare workers and communities to protect themselves primarily by preparing worker trainers to deliver disaster awareness classes. We will include two new partners, the American Federation of State, County and Municipal Employees (AFSCME), and the Association of Occupational and Environmental Clinics (AOEC), continue Plume Software and pandemic and our work with other NIEHS Grantees.

PROJECT_TERMS: Academy;Adult;American;Authorization documentation;Awareness;bilingualism;Biological;Chemicals;Cities;Clinic;Communicable Diseases;Communities;Computer software;Computers;County;Deep South;design;Development;Disaster Planning;disaster resilience;Disasters;Education;Educational Curriculum;Educational process of instructing;Educational Technics;Emergency response;Employee;Evaluation;experience;Face;Fire - disasters;First Aid;Floods;Food;Funding;Future;Geographic Locations;Goals;Government;hazard;Health;Health Hazards;Health Professional;Healthcare;Hour;Hurricane;Immigrant;Immigrant worker;improved;Industrialization;Joints;Knowledge;Language;Latino;Learning;Location;manufacture;Marketing;member;Midwestern United States;Minority;Modeling;Molds;Municipalities;National Institute of Environmental Health Sciences;Natural Disasters;Occupational;Occupational Health;Occupations;Ohio;outreach;Pamphlets;pandemic disease;Participant;Physicians;programs;promote resilience;Public Health;Public Sector;Puerto Rico;Quality Control;Rain;Readiness;Recovery;remediation;response;Rights;Rotation;Safety;Site;skills;Spanish;Spanish/English;Students;Target Populations;Time;Trainers Training;Training;training data;Training Programs;Trauma;Travel;Universities;volunteer;Work;Workplace

PROJECT_TITLE: Multi Union National Disaster Preparedness and Response Training program


NIH_SPENDING_CATS: Aging;Neurosciences;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Rehabilitation;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_CITY: LEXINGTON

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because the injured spinal cord does not heal properly resulting in chronic paralysis and expensive health care costs for patients with spinal cord injuries. There are few therapies for treating spinal cord injury and although there are increased incidences of injury in older individuals, age is not considered in most research. The proposed research will examine age-related inflammatory mechanisms of spinal cord injury progression using a clinically relevant drug and is therefore relevant to the part of the NIH mission that pertains to developing fundamental knowledge and applying that knowledge to foster innovative research strategies to reduce the burden of human disabilities.

PI_NAMEs: GENSEL, JOHN C (contact);PATEL, SAMIRKUMAR

PROGRAM_OFFICER_NAME: BAMBRICK, LINDA LOUISE

PROJECT_TERMS: 5 year old;Acetyl Coenzyme A;Age;age related;age-related disease;aged;Aging;Anatomy;Animal Model;Anti-Inflammatory Agents;Automobile Driving;axonal sprouting;Bioenergetics;Cardiovascular Diseases;Catalogs;Chronic;Citric Acid Cycle;Clinical;clinical practice;clinically relevant;Data;design;Diabetes Mellitus;Dichloroacetate;disability;Disease Progression;Dose;Drug Formulations;Evaluation;experimental study;extracellular;Fostering;Functional disorder;Gatekeeping;Genetic;Genetic Transcription;Genus Hippocampus;Gliosis;Glucose;Glycolysis;Health;Health Care Costs;Human;immunomodulatory therapies;immunoregulation;Impairment;improved;In Vitro;in vivo;Incidence;Inflammation;Inflammatory;inhibitor;Injury;injury recovery;innovation;insight;juvenile animal;kinase inhibitor;Knockout Mice;Knowledge;Label;Laboratories;Link;liposomal formulation;Liposomes;Locomotor Recovery;Macrophage;Macrophage Activation;Malignant Neoplasms;Measures;Metabolic;Metabolic dysfunction;Metabolic Pathway;metabolic profile;Metabolism;metabolomics;Microglia;Mission;Modeling;Mus;Myeloid Cells;Nervous System Trauma;neuroinflammation;neuronal survival;Neurosciences;novel;old mice;Older Population;Outcome;Oxidative Phosphorylation;Oxygen Consumption;Paralysed;Pathologic;Pathology;Pathway interactions;Patients;PDH kinase;Peripheral;Pharmaceutical Preparations;pharmacologic;Population;Public Health;Publishing;Pyruvate;pyruvate dehydrogenase;Reaction;Recovery;Recovery of Function;repair function;Reporting;Research;response;Role;Secondary to;Sensory;single-cell RNA sequencing;Spinal Cord Contusions;Spinal cord injury;stable isotope;Techniques;Testing;Therapeutic;Therapeutic Effect;therapeutic evaluation;therapeutic target;Time;tissue repair;Tissues;tool;Translating;translational impact;treatment strategy;United States National Institutes of Health;Work

PROJECT_TITLE: The role of macrophage metabolism and age in recovery from spinal cord injury

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CN-T(90)S]


NIH_SPENDING_CATS: Autism;Brain Disorders;Congenital Structural Anomalies;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Regenerative Medicine

ORG_CITY: COLLEGE STATION

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR

ORG_STATE: TX

PHR: PROJECT NARRATIVE Investigating neural stem cell behavior in the developing brain in vivo may provide key insights into the pathogenesis of developmental disabilities and reveal important clues on the design of in vitro brain tissue engineering. Using the embryonic mouse neocortex as an experimental system, this project aims to elucidate basic principles underlying the self-organization of neural stem cells during brain tissue morphogenesis.

PI_NAMEs: XIE, ZHIGANG  (contact)

PROGRAM_OFFICER_NAME: LAVAUTE, TIMOTHY M

PROJECT_TERMS: Apical;autism spectrum disorder;autocrine;Brain;brain cell;brain tissue;cell behavior;Cell Cycle;Cell Differentiation process;Cell Proliferation;conditional knockout;convergent extension;Data;Defect;design;Development;Developmental Disabilities;Electroporation;Embryo;Embryonic Development;Ensure;Equilibrium;Event;Experimental Designs;experimental study;Gene Silencing;Impairment;in utero;In Vitro;in vivo;Inhibition of Cell Proliferation;insight;Knock-out;Lead;Ligands;Link;mechanical signal;Mediating;migration;Mitosis;Modeling;Morphogenesis;Movement;Mus;Neocortex;neocortical;nerve stem cell;neurogenesis;neuromechanism;Neurons;neuroregulation;novel;Nuclear;Organoids;paracrine;Pathogenesis;Pathway interactions;planar cell polarity;Plasmids;Proliferating;Risk;risk variant;Role;self organization;Shapes;Signal Transduction;stem cell proliferation;Structure;Surface;System;Testing;Thick;Tissue Engineering;Tissue Expansion;Tissues;WNT11 gene;WNT5A gene

PROJECT_TITLE: Mechanism and function of interkinetic nuclear migration in mouse embryonic neural stem cells

STUDY_SECTION: NCF

STUDY_SECTION_NAME: Neurogenesis and Cell Fate Study Section[NCF]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Machine Learning and Artificial Intelligence;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: NEW HAVEN

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE  This study aims to deepen our understanding and help address racial/ethnic disparities in ADRD and ADRD-attributable health care using a life course approach. We will apply machine learning to nationally representative longitudinal surveys and administrative data to examine how early-life circumstances may accumulate over the life course in ways that differ across populations to shape ADRD risk and its racial/ethnic disparities; how risk factors in midlife and later life may explain racial/ethnic disparities in ADRD-related health care use and outcomes for persons with ADRD. Our overarching goal is to address ADRD-related health and health care inequities, guided by novel evidence starting from early stages of life, and ideally delay the onset or slow the progression of ADRD.

PI_NAMEs: CHEN, XI  (contact)

PROGRAM_OFFICER_NAME: BANDIERA, FRANK

PROJECT_TERMS: Address;Affect;alcohol misuse;Algorithms;Alzheimer disease prevention;Alzheimer's disease diagnosis;Alzheimer's disease model;Alzheimer's disease related dementia;Alzheimer's disease risk;Ambulatory Care;American;Behavioral;Biological;Black Populations;Caring;Cause of Death;Childhood;Clinical;clinical care;clinical diagnosis;clinical trial participant;community-level factor;Cost Control;cost effective;Data;Data Set;dementia care;dementia risk;Development;Diabetes Mellitus;Diagnosis;diagnostic tool;Disease;Disparity;Early Diagnosis;Education;Emergency department visit;Environment;Environmental Risk Factor;ethnic disparity;ethnic minority;Ethnic Origin;Family;Future;Goals;Health;Health and Retirement Study;health care disparity;health care service utilization;Healthcare;high risk population;Hispanic Populations;Home;Hospitalization;Hypertension;improved;Incidence;Individual;Inequity;Knowledge;late life;Life;Life Cycle Stages;life history;Link;Longitudinal Surveys;Machine Learning;machine learning algorithm;machine learning model;Measures;Mediating;Mediator;Medical;Medicare;Mental Depression;middle age;Modeling;Nature;Neuropsychology;Not Hispanic or Latino;novel;Obesity;Older Population;Outcome;Pattern;Patterns of Care;Persons;physical inactivity;Policies;Population;pre-clinical;Prevalence;prevent;Prevention;Preventive care;preventive intervention;Process;Race;racial disparity;racial minority;random forest;Research Personnel;Risk Factors;risk prediction model;Role;Sampling;screening;Shapes;Smoking;social;Social isolation;Societal Factors;sociocultural determinant;Specificity;Time;Trees

PROJECT_TITLE: A Life Course Approach to Understanding Racial and Ethnic Disparities in Alzheimer's Disease and Related Dementias and Health Care

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-K(90)]


ADMINISTERING_IC: AR

ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Genetics;Lung;Muscular Dystrophy;Myotonic Dystrophy;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: ROCHESTER

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: Project Narrative: Myotonic dystrophy is the most common dystrophy in adults, where muscle weakness resulting in respiratory failure is the leading cause of mortality. This proposal studies the mechanisms responsible for muscle weakness with focus on dysregulated calcium homeostasis and excitability. Results from this study will provide important insight into understanding DM1 pathogenesis and lay the groundwork for development of future therapeutic interventions.

PI_NAMEs: LUECK, JOHN D. (contact)

PROGRAM_OFFICER_NAME: CARIFI, EMILY FORAN

PROJECT_TERMS: Action Potentials;Adult;Affect;Age;Alternative Splicing;Breeding;Calcium;Calcium Channel;Calcium Channel Blockers;Calpain;Cessation of life;channel blockers;Clinic;combinatorial;Coupling;CUG repeat;Defect;design;Development;Drug Targeting;effective therapy;Evolution;Exclusion;Exhibits;Exons;feeding;fetal;Future;Genes;Genetic Transcription;Goals;Health;Heart Block;Heterozygote;Histology;Homeostasis;Human;Hypercapnia;Impairment;improved;in vivo;Individual;insight;Life;life span;Limb structure;Link;Longitudinal Studies;Measures;Membrane;Mitochondria;Modeling;Morphology;mortality;mouse model;Mus;Muscle;Muscle Fibers;Muscle function;muscle strength;Muscle Weakness;Myopathy;Myotonia;Myotonic Dystrophy;myotonic dystrophy protein kinase;Myotonic dystrophy type 1;Neonatal;Nuclear RNA;Oral;Oxygen saturation measurement;Paresis;Pathogenesis;Pathologic;Patients;Perinatal;Pharmaceutical Preparations;pharmacologic;Phenotype;Plethysmography;posttranscriptional;premature;Process;Protein Isoforms;Proteins;Proteolysis;ranolazine;reconstitution;Regulation;respiratory;Respiratory Diaphragm;Respiratory Failure;Respiratory Mechanics;Respiratory physiology;response;RNA;RNA Splicing;Running;RyR1;SERCA1;Series;Skeletal Muscle;skeletal muscle weakness;species difference;targeted treatment;Techniques;Testing;Therapeutic;Therapeutic Intervention;Toxic effect;Transcript;transcriptome;Treatment Protocols;United States Food and Drug Administration;Verapamil;Weight Gain

PROJECT_TITLE: Mechanism of Skeletal Muscle Calcium Dysregulation in Myotonic Dystrophy


NIH_SPENDING_CATS: Aging;Biotechnology;Cancer;Genetics

ORG_CITY: CORVALLIS

ORG_NAME: OREGON STATE UNIVERSITY

ORG_STATE: OR

PHR: Narrative Oxidative stress is an important but poorly understood component of most human diseases. The discovery and understanding of enzymes that can reverse some effects of oxidative stress on proteins in cells will provide approaches to treat human diseases including ALS, Alzheimer’s, arthritis, atherosclerosis, cancer, chronic pain, infection, inflammation, lung injury, organ rejection, Parkinson’s disease, sepsis, stroke and xenograft rejection.

PI_NAMEs: MEHL, RYAN A (contact)

PROGRAM_OFFICER_NAME: SIMONOVIC, MILJAN

PROJECT_TERMS: 3-nitrotyrosine;Acceleration;ALS pathology;Alzheimer's Disease;Amino Acids;Amyotrophic Lateral Sclerosis;Animal Model;Applied Genetics;Arthritis;Atherosclerosis;Back;Bacteria;Biological Assay;Biological Markers;Cell Culture Techniques;Cells;Cellular biology;chronic pain;Collaborations;Colon Carcinoma;Development;Disease;Enzymatic Biochemistry;Enzymes;Escherichia coli;Eukaryotic Cell;Evaluation;Excision;Family;Genetic Code;Growth;Hand;human disease;improved;In Vitro;in vivo;Infection;Inflammation;inhibitor;insight;Knock-out;Lead;Libraries;Literature;lung injury;Malignant Neoplasms;Mammalian Cell;MAPK3 gene;Maps;Methods;Modification;mouse model;Mus;Nerve Degeneration;nitration;organ transplant rejection;Oxidative Stress;Parkinson Disease;Pathologic;Pathology;paxillin;Phosphoric Monoester Hydrolases;Physiological;Physiology;Post-Translational Protein Processing;Process;Property;Protein Tyrosine Phosphatase;Proteins;Proteome;Qualifying;Reactive Nitrogen Species;receptor;Recombinant Proteins;Regulation;Reporting;Research;response;Role;Sepsis;Severities;Signal Transduction;Site;Specificity;Speed;Stress;Stroke;structural biology;Structural Models;Structure-Activity Relationship;Substrate Interaction;Substrate Specificity;success;Suicide;Technology;Tertiary Protein Structure;Therapeutic Intervention;Time;Tissues;tool;tumor growth;Tumor Suppressor Proteins;Tyrosine;Universities;Work;Xenograft procedure

PROJECT_TITLE: Defining roles of nitroTyrosine in desease via genetic code expansion

STUDY_SECTION: SBCB

STUDY_SECTION_NAME: Synthetic and Biological Chemistry B Study Section[SBCB]


ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Project Narrative  Hypertension is the leading cause of death and disability-adjusted life years worldwide, and there is a major unmet need for new therapeutic options. Research outlined in this proposal will significantly advance our understanding of the role of the immune system in the development of hypertension. Knowledge gained from this work will aid in the development of new therapeutic targets and strategies for this disease.

PI_NAMEs: ALEXANDER, MATTHEW R (contact)

PROGRAM_OFFICER_NAME: LIDMAN, KARIN FREDRIKSSON

PROJECT_TERMS: Academic Medical Centers;adaptive immunity;Address;Adoptive Transfer;Angiogenesis Inhibition;Angiotensin II;Animal Model;Aorta;beta-Chemokines;Blood;Blood flow;Blood Pressure;blood pressure control;blood pressure elevation;Blood Vessels;Cardiac;cardiovascular risk factor;career;Cause of Death;CD4 Positive T Lymphocytes;Cells;chemokine;chemokine receptor;Chronic Kidney Failure;Circulation;Coculture Techniques;Control Animal;Coronary Arteriosclerosis;Cytometry;density;Development;disability-adjusted life years;Disease;Endothelial Cells;Endothelium;Event;experimental study;Exposure to;Fibrosis;genetic approach;Goals;Heart failure;Hepatocyte;Human;Human Genetics;Hypertension;hypertensive;Immune;Immune system;In Vitro;in vivo Model;Individual;Inflammation;Inflammatory;insight;Insulin-Dependent Diabetes Mellitus;Knowledge;Ligands;Link;Mechanics;Mendelian randomization;Mentorship;migration;Modeling;Morbidity - disease rate;mortality;mouse model;Mus;Myocardial Ischemia;new therapeutic target;normotensive;novel;novel therapeutics;Pathogenesis;Pathogenicity;Patient Care;Patients;Periodicity;Peripheral Blood Mononuclear Cell;Phenotype;Physicians;Play;Population;Pulmonary Fibrosis;recruit;Regulatory T-Lymphocyte;Research;Resources;response;Risk Factors;Rodent;Role;Scientist;skills;Skin;Sodium Chloride;Stretching;Stroke;T-Lymphocyte Subsets;Testing;therapeutic target;TNF gene;Umbilical vein;Vascular resistance;Work

PROJECT_TITLE: The Role of CCR10+ Regulatory T Cells In Hypertension

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(MA)]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Mental Illness;Neurosciences;Post-Traumatic Stress Disorder (PTSD);Prevention;Social Determinants of Health;Substance Misuse;Violence Research

ORG_CITY: AUSTIN

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

PHR: This application describes a research plan for a longitudinal study in adults with PTSD, interpersonal violence exposure but no PTSD, and healthy comparison adults aimed at capturing biological risk factors that are predictive of alcohol use disorders. The goals of the research are to investigate alcohol induced changes in approach avoidance behavior, and underlying neural circuitry, and relations with the emergence of problematic alcohol use. Findings may inform prediction models of alcohol use disorders and treatment approaches that are more specific for PTSD.

PI_NAMEs: CISLER, JOSHUA M;LIPPARD, ELIZABETH THOMAS COX (contact)

PROGRAM_OFFICER_NAME: BALAKATHIRESAN, NAGARAJA SETHURAMAN

PROJECT_TERMS: Acute;Address;Adult;Affect;Alcohol abuse;alcohol comorbidity;Alcohol consumption;alcohol cue;alcohol effect;alcohol exposure;alcohol misuse;alcohol risk;alcohol use disorder;Alcoholic Intoxication;Alcohols;approach/avoidance behavior;Behavioral;Behavioral Mechanisms;Beverages;Biological;Brain;Clinical;clinical prognosis;Clinical Research;Cognitive deficits;comorbidity;comparison group;computational neuroscience;Computer Models;Corpus striatum structure;Data;Decision Making;Development;Diagnosis;Disease;expectation;Extinction;follow-up;Fright;Functional disorder;General Population;Goals;Heavy Drinking;high risk;Human;improved;improved outcome;Individual;Interpersonal Violence;Intervention;Intoxication;Learning;Longitudinal Studies;Mediating;Methods;Modeling;neural;neural circuit;neural network;neuroimaging;neurophysiology;novel;Outcome;Participant;Pattern;pharmacologic;Placebo Control;Placebos;Post-Traumatic Stress Disorders;Predictive Factor;predictive modeling;Prevalence;Prevention;Procedures;programs;Psychophysiology;Relapse;Research;Research Personnel;reward processing;Rewards;Risk;Risk Behaviors;Risk Factors;Risk Marker;Role;Self Medication;Severities;social;suicidal risk;Symptoms;Testing;therapy development;Time;Trauma;violence exposure;Woman;Work

PROJECT_TITLE: Alcohol, Approach-Avoidance, and Neurocircuitry Interactions in PTSD

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Nutrition;Obesity

ORG_CITY: CHAPEL HILL

ORG_DEPT: NUTRITION

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: Project Narrative There is an urgent need to create sustainable systems to facilitate the success of diverse faculty, particularly because the diseases central to the mission of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) disproportionately impact populations of color. The proposed North Carolina Consortium for Diversity Career Development in Nutrition, Obesity, and Diabetes Research (NC(CD)2NOD) builds on the extensive infrastructure already in place within and across our six institutions to offer a robust Pilot and Feasibility Program and carefully curated programs for professional development to support the success of diverse scientists in the conduct of research in nutrition, obesity, diabetes, and related conditions. Building on our substantial existing NIDDK funding, the NC(CD)2NOD will markedly enhance the diversity of the research workforce, preparing scholars to make significant scientific contributions via independent NIH research funding in the critical areas of nutrition, obesity, diabetes, and related conditions for years to come.

PI_NAMEs: COOK, MARC D;SHAIKH, SAAME R (contact);TRUESDALE, KIMBERLY P

PROGRAM_OFFICER_NAME: EVANS, MARY

PROJECT_TERMS: Agriculture;Area;Authorship;Award;Biomedical Research;Black race;career;career development;Career Mobility;Clinical and Translational Science Awards;cohort;Collaborations;Collection;Community based prevention;Data;Dedications;design;Development;Diabetes Mellitus;Disease;Disparity;Doctor of Philosophy;early-career faculty;Effectiveness;Ensure;Equipment;Evaluation;Faculty;Financial Support;follow-up;Funding;Funding Opportunities;Future;Gender;Goals;Health;Historically Black Colleges and Universities;improved;Individual;Infrastructure;innovation;Institution;Letters;Literature;medical schools;member;Mentors;Mission;National Institute of Diabetes and Digestive and Kidney Diseases;North Carolina;nutrition;Obesity;people of color;Persons;Postdoctoral Fellow;Prevention Research;Principal Investigator;Problem Solving;programs;Quality of life;Race;Research;Research Personnel;Scientific Advances and Accomplishments;Scientist;success;supportive environment;System;Training;training opportunity;Underrepresented Populations;United States National Institutes of Health;Universities;Work


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_NAME: MAYO CLINIC ROCHESTER

PHR: PROJECT NARRATIVE Analyzing the transcriptional profiles of single microbial and innate immune cells during their interaction can lead to better understanding of how one influences the other in a direct and indirect manner. This information can provide mechanistic insights on how microbes and innate immune system co-evolve over time. This proposal is centered on the optimization and use of a microfluidic single cell sequencing platform to unravel this interaction which can eventually help understand the underlying mechanism of the maintenance and disruption of microbe- immune system symbiosis.

PI_NAMEs: LIU, YUGUANG  (contact)

PROGRAM_OFFICER_NAME: ZHAO, XIAOLI

PROJECT_TERMS: Acceleration;adaptive immunity;Animal Model;Biological Process;Biology;Cell Communication;cell type;Cells;Coculture Techniques;Complex;Dendritic Cells;Ecosystem;Environmental Risk Factor;Gene Expression Profile;Genetic Transcription;genome sequencing;Goals;Health;Human;Immune;Immune response;Immune system;Individual;Innate Immune System;insight;Maintenance;Maps;metagenomic sequencing;Methods;Microbe;microbial;microbiome research;Microfluidics;Monitor;Mutation;Natural Immunity;Phenotype;Play;Population;Process;programs;Research;response;rRNA Genes;sequencing platform;Signal Pathway;Signal Transduction;single cell sequencing;Staphylococcus aureus;Symbiosis;Time;tool;Training;transcriptome sequencing;whole genome;Work

PROJECT_TITLE: Deciphering microbial-immune cell interaction using single cell approaches

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-GGG-X(55)R]


ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE Researchers from underrepresented backgrounds face significant challenges throughout their careers and leave academic research at a higher rate than majority peers. Our comprehensive career development program, COURAGE, will serve two cohorts of 10 researchers in obesity, nutrition, and diabetes who are from underrepresented backgrounds, providing skill building and leadership training, hands-on guidance in manuscript and grant writing, and multi-level mentoring to support career advancement and continued success in academic research.

PI_NAMEs: MORONE, NATALIA E.;STANFORD, FATIMA CODY;STANLEY, TAKARA LEAH (contact)

PROJECT_TERMS: Academia;Address;Advocate;Affect;Applications Grants;Area;Award;Biomedical Research;Black Populations;Boston;Budgets;career;career development;Career Mobility;Clinical Trials;cohort;Collaborations;Communities;Country;Data Analyses;Development Plans;Diabetes Mellitus;Discipline;Disease;Education;Educational Curriculum;Educational workshop;Epidemiologist;ethnic diversity;experience;Face;Faculty;faculty mentor;General Hospitals;Goals;Grant;Growth;Health Care Research;Hispanic Populations;Individual;Institution;Intervention;Lead;Leadership;leadership development;Learning Skill;Manuscripts;Massachusetts;Mediation;Medical;Medical center;Medicine;meetings;Mentors;Mentorship;Minority Groups;Minority Health Research;Modeling;Morehouse School of Medicine;Morones;Non-Insulin-Dependent Diabetes Mellitus;nutrition;Obesity;Participant;peer;peer networks;Persons;Phase;Pilot Projects;Positioning Attribute;Postdoctoral Fellow;Preparation;Productivity;Program Development;programs;Publications;Puerto Rico;racial diversity;recruit;Research;Research Personnel;Research Project Grants;Resources;Science;Scientist;Self Assessment;Series;Site;skills;success;Testing;Time Management;Training;Underrepresented Populations;United States;United States National Institutes of Health;Universities;Work;Writing

PROJECT_TITLE: Creating Opportunities for Underrepresented Researchers to Achieve Growth and Excellence (COURAGE)


ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: NARRATIVE Keratins comprise a large family of cytoskeletal filament-forming proteins that are highly abundant in epidermis and skin epithelia, where they fulfill a broad range of important roles including structural support. Genetically-determined mutations altering the sequence of keratin proteins account for a large number of individually rare but devastating skin diseases. This project is focused on further defining an emerging role for keratins in regulating differentiation in the epidermis and skin epithelial appendages, and how the relevant processes are affected in keratin-based skin disorders.

PI_NAMEs: COULOMBE, PIERRE  (contact)

PROGRAM_OFFICER_NAME: KOCH, PETER

PROJECT_TERMS: Accounting;Adaptor Signaling Protein;Affect;Alleles;appendage;Architecture;Automobile Driving;Binding;Binding Sites;Biochemistry;Bullous Congenital Ichthyosiform Erythroderma;Cell Physiology;Cells;Cessation of life;Code;Coupled;Cysteine;Cytokeratin filaments;Cytoplasm;Cytoskeletal Filaments;Cytoskeletal Proteins;Defect;Disease;disease-causing mutation;disulfide bond;Disulfides;Ectoderm;Endowment;Epidermis;Epidermolysis Bullosa Simplex;Epithelial Cells;Epithelium;Equilibrium;Exhibits;Family;Fostering;Functional disorder;Gene Expression;Gene Family;Genes;Growth;Hair follicle structure;high throughput screening;Homeostasis;Human;Impairment;in vivo;Individual;insight;Intermediate Filament Gene;Intermediate Filament Proteins;Intermediate Filaments;Keratin;keratin 5;keratinocyte;keratinocyte differentiation;Knock-in;Knockout Mice;Learning;Link;live cell imaging;Maintenance;Maps;mechanical signal;Mechanics;Mediating;Medicine;Metabolism;migration;mouse model;Mutation;notch protein;pachyonychia congenita;Phenotype;Phosphotransferases;Play;Pliability;Population;Post-Translational Protein Processing;Process;progenitor;Proliferating;Property;protein function;Protein Isoforms;Proteins;Regulation;Research;resilience;response;Role;scaffold;Signal Transduction;Skin;skin disorder;Societies;Source;Specific qualifier value;Specificity;Stress;Structure;Stuttering;Surface;Sweat Glands;Testing;Therapeutic;Tissues;Tooth structure;Transcriptional Regulation;transcriptomics;Transgenic Mice

PROJECT_TITLE: Role of keratin intermediate filaments in skin epithelial differentiation.


NIH_SPENDING_CATS: Arthritis;Autoimmune Disease

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative The aim of the proposed program is to train postdoctoral fellows with MD, MD-PhD and PhD degrees in molecular and translational rheumatology research. The program will offer mentored research opportunities in three different but interconnected themes. The ultimate goal is to provide trainees of outstanding promise the tools and skills that will be needed to make key discoveries and to develop productive research careers in academic rheumatology.

PI_NAMEs: BATHON, JOAN MARIE (contact);WINCHESTER, ROBERT J

PROGRAM_OFFICER_NAME: VINCENT, ISAAH S

PROJECT_TITLE: Multidisciplinary Training in Molecular and Translational Rheumatology Research


ORG_CITY: JOHNSON CITY

ORG_DEPT: SURGERY

ORG_NAME: EAST TENNESSEE STATE UNIVERSITY

PHR: Project narrative.  The critically ill patient frequently develops a complex disease spectrum that may include respiratory distress, systemic inflammation, infection, shock and failure of major organs. It is clear that new and novel approaches to the treatment of sepsis are needed. To address this pressing problem, we propose the novel concept that it may be possible to “train” the compromised immune system, such that it can prevent or significantly reduce this deadly and costly disease.

PI_NAMEs: SHERWOOD, EDWARD R;WILLIAMS, DAVID L. (contact)

PROJECT_TERMS: Acetyl Coenzyme A;Acute;Acute Respiratory Distress Syndrome;Address;Adult;Age;Age Years;aged;Aging;antimicrobial;Automobile Driving;beta-Glucans;Cause of Death;Citrates;Citric Acid Cycle;clinically relevant;cognitive disability;comorbidity;Complex;Cost of Illness;Critical Illness;cytokine;Data;Death Rate;Disease;effective therapy;Elderly;epigenome;epigenomics;Event;Expenditure;experience;experimental study;Failure;FDA approved;Functional disorder;Gene Expression;Generations;Grant;hospital readmission;Hospitals;Human;human disease;human old age (65+);Immune;immune function;Immune system;Immune System Diseases;Immunity;Immunologic Memory;Immunosuppression;improved;in vivo;in vivo Model;Incidence;Individual;Infection;Inflammatory Response;innate immune mechanisms;Innate Immune System;Institution;Intensive Care Units;Leukocytes;Long term physical disability;Macrophage;Maintenance;Metabolic;metabolic phenotype;Mitochondria;Modeling;Molecular;monocyte;mortality;Multiple Organ Failure;Natural Immunity;novel;novel strategies;Organ;Outcome;pathogen;Patients;Phagocytosis;Pharmaceutical Preparations;Phenotype;prevent;Production;programs;recurrent infection;Reporting;Research;Resistance to infection;Respiratory Burst;Respiratory distress;response;Role;Science;secondary infection;Secondary to;Sepsis;Sepsis Syndrome;septic;septic patients;Septic Shock;Severities;Shock;Signal Transduction;Syndrome;systemic inflammatory response;Systemic Inflammatory Response Syndrome;Time;Training;Training Support;transcriptomics;United States;United States National Institutes of Health

PROJECT_TITLE: Training Innate Immunity: A new approach to the treatment of Sepsis

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


NIH_SPENDING_CATS: Genetics

ORG_CITY: SYRACUSE

ORG_NAME: UPSTATE MEDICAL UNIVERSITY

PHR: Project Narrative These proposed studies will investigate the molecular basis for the role of DNA methylation in the liquid- liquid phase separation (LLPS)-mediated heterochromatin assembly, using an array of highly sensitive biophysical techniques like NMR spectroscopy and fluorescence microscopy. We will also investigate the mechanism of cross-talk between DNA methylation and histone methylation using both wild type and disease-relevant mutations. This research will provide new insights into the underlying mechanisms of several cancers and severe neurodevelopmental disorders such as Rett Syndrome.

PI_NAMEs: BAH, ALAJI  (contact)

PROGRAM_OFFICER_NAME: CHOW, CHI-WING

PROJECT_TERMS: Binding Proteins;biophysical techniques;Chromatin;Complex;Disease;DNA;DNA Methylation;DNA Repair;DNA-Binding Proteins;Enzymes;Epigenetic Process;Euchromatin;Fluorescence Microscopy;Gene Expression;Gene Silencing;Genes;Genetic Recombination;Genetic Transcription;Heterochromatin;histone methylation;histone modification;Histones;insight;Knowledge;Liquid substance;Malignant Neoplasms;Mediating;Modification;Molecular;Mutation;Neurodevelopmental Disorder;NMR Spectroscopy;Pattern;Phase;Protein Methylation;Research;Rett Syndrome;Role;Structure;Tail

PROJECT_TITLE: Role of DNA Methylation in Liquid-liquid Phase Separation-mediated Heterochromatin Formation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-K(55)R]


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: SEATTLE

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Genetic and electronic prostheses show great promise for restoring vision in blind humans. Unfortunately, our understanding of the circuitry mediating vision in the retina lags significantly behind retinal prosthetic technology. This research will greatly advance our current understanding of how motion processing occurs in the retina and will make an immediate contribution to prosthetic technologies aimed at restoring vision.

PI_NAMEs: MANOOKIN, MICHAEL B (contact)

PROGRAM_OFFICER_NAME: WRIGHT, CHARLES BAKER

PROJECT_TERMS: Affect;Anatomy;Animals;Belief;blind;Brain;cell cortex;cell type;Cells;circadian;Collection;Color;color processing;Color Visions;Complex;Cone;Data;design;Detection;Development;dorsal visual stream;Electronics;Exhibits;experimental study;ganglion cell;Genetic;Goals;Human;improved;insight;Kinetics;Light;Macaca;Mediating;Modeling;Monkeys;Motion;motion sensitivity;multi-electrode arrays;Mus;neural;neural circuit;neural network;Neural Pathways;neuromechanism;Neurosciences;object motion;orientation selectivity;Output;Pathway interactions;Pattern;Physiological;Physiology;Population;Primates;Property;Prosthesis;receptive field;Research;response;Retina;retinal axon;Retinal Ganglion Cells;retinal prosthesis;Role;Shapes;sight restoration;Signal Transduction;spatiotemporal;Stimulus;Structure;Synapses;System;Techniques;Technology;Testing;Thalamic structure;Training;Vertebrates;Vision;Visual;visual information;Visual Motion;visual processing;Visual System;Whole-Cell Recordings

PROJECT_TITLE: Function, diversity, and circuitry of parallel retinal ganglion cell pathways

STUDY_SECTION: BDE

STUDY_SECTION_NAME: Biology and Development of the Eye Study Section[BDE]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Health Services;Neurodegenerative;Neurosciences;Patient Safety;Physical Injury - Accidents and Adverse Effects

ORG_CITY: PROVIDENCE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: PROJECT NARRATIVE Drug interactions resulting from the use of multiple medications are a major cause of fall-related injuries and other clinically significant adverse events in older nursing home residents with Alzheimer's disease and related dementias. This research will exhaustively identify important drug interactions and rigorously examine their effects on fall-related injuries in older nursing home residents with Alzheimer's Disease and Related Dementias. Study findings will provide evidence that directly informs medication prescribing, deprescribing, and management to improve the safe use of medications among older adults with Alzheimer's Disease and Related Dementias.

PI_NAMEs: ZULLO, ANDREW REIS (contact)

PROGRAM_OFFICER_NAME: SALIVE, MARCEL

PROJECT_TERMS: Address;Adverse drug event;Adverse event;adverse outcome;Affect;Alzheimer's disease related dementia;analytical method;Cessation of life;Clinical assessments;clinical practice;clinically actionable;clinically significant;Computer software;Dangerousness;Data;data resource;Data Set;Databases;disability;Dose;Drug Interactions;Drug Prescriptions;Drug usage;Electronic Health Record;epidemiology study;fall injury;fall risk;falls;Fatigue;Fracture;frailty;functional decline;Future;Goals;Health Insurance;Health Personnel;Hemorrhage;high risk;Hospitalization;Impaired cognition;improved;Individual;Injury;innovation;Joint Dislocation;Link;Medical;Medicare;Medicare claim;Medication Management;Methodology;Methods;Mobility decline;modifiable risk;Morbidity - disease rate;multidisciplinary;multiple chronic conditions;National Institute on Aging;Nature;novel;novel therapeutics;Nursing Homes;older adult;Outcome;Pain;Pharmaceutical Preparations;Polypharmacy;Population;Provider;randomized, clinical trials;Records;Regimen;Research;Research Personnel;Risk;Risk Factors;risk minimization;screening;Screening Result;Series;Subgroup;Symptoms;Testing;Time;Validation;validation studies

PROJECT_TITLE: Clinically Significant Drug Interactions among Nursing Home Residents with ADRD