ORG_DEPT: PEDIATRICS

PHR: We study the impact of high shear stress on the aberrant regulation of genes that leads to functional abnormalities causing occlusion of pulmonary arteries in pulmonary arterial hypertension. We build vascular tubular structures to study endothelial interaction with smooth muscle cells under high shear stress, and pursue the genomic and functional sequelae resulting from a reduction in a critical transcription factor, ERG, and how these abnormalities can be corrected.

PI_NAMEs: RABINOVITCH, MARLENE  (contact)

PROGRAM_OFFICER_NAME: XIAO, LEI

PROJECT_TERMS: Address;Adhesions;Affect;Algorithms;Arteries;ATAC-seq;Biological Assay;Biomanufacturing;bioprinting;Blood flow;Blood Pressure;Blood Vessels;BMPR2 gene;Cell Communication;Cell Physiology;Cell Proliferation;Cells;ChIP-seq;Chromatin;chromatin remodeling;Collaborations;Congenital Heart Defects;Data;Deposition;derepression;differential expression;Disease;Distal;DNA;DNA Binding;Elastin;Elastin Fiber;Endothelial Cells;Endothelium;Enhancers;Exposure to;Family;Fibrin;Functional disorder;Funding;Gel;Gene Expression;Gene Expression Regulation;gene function;Genes;genetic variant;Genomics;Heterozygote;Homeostasis;Impairment;Inflammation;Intervention;Knock-out;Left;Link;Lung;MADH3 gene;Maps;Mediating;member;Mesenchymal;Metabolism;monocyte;mortality;Mus;Muscle Cells;Natural regeneration;Nature;neutrophil;NF-kappa B;novel;Obstruction;Pathology;Patients;Peripheral;Permeability;Physiological;prevent;promoter;Proteins;pulmonary arterial hypertension;pulmonary artery endothelial cell;Pulmonary artery structure;Pulmonary Hypertension;Pulmonary Vascular Resistance;recruit;Reporting;Research Personnel;response;right ventricular failure;shear stress;Shunt Device;Site;Smooth Muscle Myocytes;Structure;SWI/SNF Family Complex;Technology;Tissues;transcription factor;transcriptome sequencing;Transgenic Mice;Tube;Tubular formation;Untranslated RNA;Vascular Diseases;Veno-Occlusive Disease

PROJECT_TITLE: High Shear Stress Alters Gene Regulation in Pulmonary Arterial Hypertension

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


ADMINISTERING_IC: AI

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Gene Therapy;Genetics;Immunization;Immunotherapy;Organ Transplantation;Orphan Drug;Prevention;Rare Diseases;Transplantation;Vaccine Related

ORG_CITY: PHILADELPHIA

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

ORG_STATE: PA

PHR: Acute and chronic alloimmune reactions against allografts are the major causes of transplantation rejection. Developing safe and effective immune suppressive treatments to achieve long-term transplantation tolerance has been difficult because we don’t have strategies to specifically intervene with multiple components of the alloimmune reactions without compromising the entire host immune system. Here we will develop an orthogonal vaccine to synthetically bridge the crosstalk between antigen presenting cells and engineered regulatory T cells to simultaneously and specifically suppress alloimmune reactions at both the effector site (allograft) and the priming site (allograft draining lymphoid tissue) for long-term transplantation tolerance.

PI_NAMEs: MA, LEYUAN  (contact)

PROGRAM_OFFICER_NAME: KEHN, PATRICIA J

PROJECT_TERMS: Acute;Adoptive Cell Transfers;age effect;Alloantigen;Allografting;allotransplant;amphiphilicity;Antigen-Presenting Cells;Antigens;Antithymoglobulin;Autoimmune Diseases;Biological;Biology;cancer therapy;CAR T cell therapy;Cells;chimeric antigen receptor;chimeric antigen receptor T cells;Chronic;Clustered Regularly Interspaced Short Palindromic Repeats;Cross Presentation;curative treatments;cytotoxic;Cytotoxic T-Lymphocytes;design;Disease;Dose;effective intervention;end-stage organ failure;Engineering;Equilibrium;Generations;Genetic;Genetic Polymorphism;Goals;Graft Rejection;graft vs host disease;Homeostasis;Human;Immune;Immune system;Immunity;Immunologic Surveillance;immunological synapse;Immunology;immunomodulatory strategy;immunoregulation;Immunosuppression;Immunosuppressive Agents;improved;in vivo;Investigation;Kinetics;life span;Ligands;lymph nodes;Lymphoid Tissue;Maintenance;Major Histocompatibility Complex;Malignant Neoplasms;Mediating;Medical;migration;Modeling;Molecular;Molecular Target;Molecular Vaccines;Mus;Nature;Opportunistic Infections;Organ;Organ Transplantation;Outcome;Pathologic;Patients;Pharmaceutical Preparations;Phenotype;Postdoctoral Fellow;preservation;prophylactic;Reaction;receptor vaccine;Regulatory T-Lymphocyte;response;Route;Signal Transduction;Site;Source;Specificity;synergism;Synthetic Vaccines;T cell response;T cell therapy;T-Lymphocyte;Tacrolimus;technology development;technology platform;therapeutic evaluation;Tissues;Training;Translations;Transplantation;Transplantation Tolerance;Vaccination;vaccination strategy;vaccine development;vaccine response;Vaccines;Vision;Work

PROJECT_TITLE: Engineering synthetic cellular crosstalk for transplantation tolerance


ADMINISTERING_IC: TW

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Clinical Research;Dissemination and Implementation Research;HIV/AIDS;Infectious Diseases;Mental Health;Prevention

ORG_CITY: CHAPEL HILL

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE The Malawi HIV integrated treatment and prevention guidelines have recently adopted evidence- based interventions including Dolutegravir based antiretroviral therapy, Pre-Exposure prophylaxis and integrated service delivery but require implementation science research to bring the interventions to scale for maximum impact. The University of North Carolina (UNC), the University of Malawi, College of Medicine (COM), Kamuzu College of Nursing (KCN) and Ministry of Health (MOH) will build upon nearly two decades of experience in HIV training activities and institutional research capacity strengthening in Malawi to expand HIV implementation science skills among research-focused faculty at COM, KCN, MOH and partner affiliates. Our program will develop both investigators and strengthen systems in the COM and KCN to assist the Malawi government to conduct high quality implementation science.

PI_NAMEs: HOSSEINIPOUR, MINA CHRISTINE (contact);MWAPASA, VICTOR

PROGRAM_OFFICER_NAME: BANSAL, GEETHA PARTHASARATHY

PROJECT_TERMS: Area;Award;career development;Caring;college;Complement;design;Discipline;Discipline of Nursing;Doctor of Philosophy;economic evaluation;Educational workshop;Ensure;Environment;Evolution;experience;Faculty;Family Practice;Feedback;Funding;global health;Goals;Grant;Guidelines;Health;HIV;implementation research;implementation science;implementation strategy;improved;Institution;Interdisciplinary Study;Internships;Leadership;Malawi;Medicine;Mentors;mHealth;Modeling;next generation;North Carolina;pre-exposure prophylaxis;Prevention;Prevention strategy;Preventive therapy;programs;Public Health;Research;Research Personnel;Research Support;Scientist;Services;Structure;Teacher Professional Development;Time;Training;Training Activity;Training Programs;Universities;Writing

PROJECT_TITLE: Malawi HIV Implementation Research Scientist Training Program (M-HIRST)


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Mental Health;Mental Illness;Neurosciences;Prevention

ORG_CITY: MILWAUKEE

ORG_DEPT: PSYCHIATRY

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: PROJECT NARRATIVE After losing a loved one, most older adults are resilient and return to normal functioning within a year; however, in some individuals acute grief becomes intense, protracted, and debilitating, leading to complicated or prolonged grief. This novel study is anticipated to provide evidence that specific abnormalities in the emotion regulation brain circuitry could, in the future, serve as neurobiological indicators of complicated grief. Such biomarkers could also be used to test the efficacies of treatment or prevention strategies that aim to prevent the development of complicated grief in older acutely grieving individuals.

PI_NAMEs: GOVEAS, JOSEPH S (contact)

PROGRAM_OFFICER_NAME: LYONS, ELIZABETH ANNE

PROJECT_TERMS: Acute;Address;Advocate;Age;Age Years;Aging;Amygdaloid structure;Behavior;Bereavement;Biological Markers;Brain;brain circuitry;brain magnetic resonance imaging;Buffers;Cessation of life;Child;Clinical;Clinical assessments;Cognitive;common symptom;connectome;coping;Data;Depressed mood;depressive symptoms;Development;Dimensions;disability;Distress;Early identification;Early treatment;efficacy testing;emotion dysregulation;emotion regulation;Emotions;Enrollment;Equation;Evolution;experience;Functional Magnetic Resonance Imaging;Future;Gender;geriatric depression;Goals;Grief reaction;Health;Human;Hyperactivity;Individual;innovation;Knowledge;longitudinal design;loss of function;loved ones;Magnetic Resonance Imaging;Measures;Medical;Mental disorders;Mental Health;Minority;National Institute of Mental Health;Negative Valence;Neurobiology;neuroimaging;Neurons;neuroregulation;novel;older adult;Older Population;Outcome;Participant;Pathologic;Pathology;Patient Self-Report;personalized intervention;Phenotype;Play;Prediction of Response to Therapy;Premature Mortality;prevent;Prevention strategy;Protocols documentation;Public Health;Quality of life;Reporting;Research Domain Criteria;resilience;response;Rest;Risk;Role;Spouses;Stimulus;suicidal risk;Suicide;Symptoms;System;theories;treatment response;treatment strategy

PROJECT_TITLE: Emotion Regulation in Complicated Grief

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Clinical Research;Machine Learning and Artificial Intelligence;Radiation Oncology

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: Narrative The definition of the clinical target volume in which high doses of radiation are delivered to treat cancer is the weakest link in the radiation therapy chain. It is currently a cumbersome manual process in which a radiation oncologist draws the target contours manually, with many uncertainties involved, leading to a large variability between contours drawn by different physicians. In collaboration with a leading company in radiation treatment planning, we develop a machine learning based approach to define the clinical target volume semi- automatically, which will lead to greater efficiency in defining the clinal target, more consistency, and better treatment plans for the patients.

PI_NAMEs: BORTFELD, THOMAS R. (contact)

PROGRAM_OFFICER_NAME: OBCEMEA, CEFERINO H

PROJECT_TERMS: 3-Dimensional;Adherence;Affect;Algorithms;Anatomy;automated algorithm;Automation;Black Box;Cancer Patient;Clinical;clinical care;clinical practice;clinical translation;Collaborations;Communities;Computing Methodologies;Consensus;Development;Disease;Dose;Glioma;Goals;Growth;Guidelines;Hospitals;Human;impression;improved;Individual;inter-institutional;interest;Judgment;Laboratories;Lead;Link;Location;Machine Learning;Malignant Neoplasms;Manuals;Methods;Microscopic;millimeter;Modernization;Muscle Fibers;Normal tissue morphology;open source;Outcome;Patients;Perception;Physicians;Process;Protocols documentation;Radiation;radiation delivery;Radiation Dose Unit;Radiation Oncologist;Radiation Oncology;Radiation therapy;Research;Role;Sarcoma;Shapes;Site;Structure;System;Targeted Radiotherapy;Technology;technology development;Testing;Therapy Clinical Trials;Time;Tissues;tool;Toxic effect;Training;treatment optimization;Treatment outcome;treatment planning;tumor;Tumor Volume;Uncertainty;Validation;Variant;Work;X-Ray Computed Tomography

PROJECT_TITLE: Automated interactive definition of the clinical target volume in radiation oncology


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Childhood Obesity;Climate-Related Exposures and Conditions;Clinical Research;Genetics;Networking and Information Technology R&D (NITRD);Nutrition;Obesity;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: Canton

ORG_NAME: HARVARD PILGRIM HEALTH CARE, INC.

PHR: Project Narrative Project Viva is a longitudinal cohort study of mothers and their children, originally enrolled during early pregnancy 1999-2002. The wealth of data and bio samples already available in the cohort provide a unique opportunity to continue to study the influence of early-life environmental exposures on development of chronic diseases including obesity, cardiovascular disease, and asthma. The support from this application will help improve the availability of Project Viva data to the wider research community, maintain participants’ engagement in the study, and position Project Viva to continue to examine novel scientific questions into the future.

PI_NAMEs: OKEN, EMILY  (contact)

PROGRAM_OFFICER_NAME: GRAY, KIMBERLY A

PROJECT_TERMS: Accelerometer;Address;adipokines;Adolescence;Air Pollution;Anthropometry;Area;Asthma;atopy;Behavior;Biological;Biological Markers;Birth;Blood Pressure;Body Composition;Boston;cardiometabolism;Cardiovascular Diseases;Cellular Phone;Child;Child Health;Chronic Disease;Cognition;cohort;Communication Methods;Communities;Complement;Data;Data Analyses;Data Collection;data management;Data Set;data sharing;data warehouse;Databases;design;Development;Diet;Dietary Assessment;DNA analysis;Documentation;early pregnancy;Ecological momentary assessment;Electronic Mail;Enrollment;Environment;Environmental Epidemiology;Environmental Exposure;Environmental Health;epigenetic marker;Fathers;Feedback;Focus Groups;follow-up;Foundations;Future;Genetic;genetic variant;Geographic Information Systems;Geography;Goals;Grant;Health;improved;indexing;Infrastructure;Infrastructure Activities;Internet;Life;Life Cycle Stages;Link;Lipids;Location;Longitudinal cohort study;Measures;member;Metals;Methods;Modernization;Monitor;Moods;Mothers;National Institute of Environmental Health Sciences;novel;Obesity;Online Systems;Outcome;Participant;patient engagement;Pattern;Perimenopause;Physical activity;Poly-fluoroalkyl substances;Positioning Attribute;Pregnancy;programs;Protocols documentation;pulmonary function;Records;Research;Research Priority;Resolution;Resources;saliva sample;Sampling;Science;search engine;Secure;sleep pattern;smartphone application;substance use;Techniques;Technology;Testing;Time;toxicant;United States National Institutes of Health;web portal;young adult

PROJECT_TITLE: Maintain and Enrich Resource Infrastructure for Project Viva: a pre-birth cohort with follow up into adolescence


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: The increase in blood pressure, called Hypertension, is the main cause of heart attack, stroke and need of dialysis; however, the causes of this disease are unknown in 90% of the patients. In this proposal, we will explore a potential cause of hypertension that originates in the malfunctioning of small arteries of the kidneys.  We believe that our proposal may explain up to ~20% of the hypertensive individuals and will help to develop new treatments.

PI_NAMEs: ROMERO, CESAR ANDRES (contact)

PROGRAM_OFFICER_NAME: HUANG, LI-SHIN

PROJECT_TERMS: Address;Advisory Committees;Agonist;Amino Acids;Animals;antagonist;Apical;Area;Arteries;arteriole;benzamil;Biological;Blood Pressure;blood pressure elevation;blood pressure regulation;Calcium;Calcium Channel;Calpain;Cardiovascular Diseases;cardiovascular risk factor;career;career development;Cells;Communication;confocal imaging;Critical Thinking;Data;Development;Development Plans;Dialysis procedure;Diet;Disease;Duct (organ) structure;Educational process of instructing;Electrophysiology (science);epithelial Na+ channel;Epithelium;Excretory function;experience;falls;Feedback;Functional disorder;Funding;Genetic;Genetic Transcription;Glomerular Filtration Rate;Glutamates;Glycine;Goals;Heart Diseases;Hematological Disease;hemodynamics;Human;Hypertension;hypertensive;Imaging Techniques;Impairment;In Vitro;in vivo;Individual;inhibitor;International;Kidney;Knockout Mice;Label;Laboratories;Liddle syndrome;Mediating;Mentors;Molecular;mortality;mRNA Expression;Mus;Myocardial Infarction;N-Methyl-D-Aspartate Receptors;N-Methylaspartate;National Heart, Lung, and Blood Institute;normotensive;novel therapeutics;Pathway interactions;Patients;Peptide Hydrolases;Perfusion;Physiological;Prevention;Principal Investigator;programs;protein protein interaction;Proteomics;Publications;Regulation;Research;Resistance;Risk Factors;Role;Signal Transduction;skills;Sodium;Sodium Chloride;Spectrum Analysis;Stroke;Techniques;Testing;therapeutic development;Tubular formation;Universities;Urine;Vasodilation

PROJECT_TITLE: N-methyl-D-aspartate receptors (NMDAr) participates in renal hemodynamic regulation and blood pressure homeostasis


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: ROCHESTER

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF ROCHESTER

ORG_STATE: NY

PHR: Human Cytomegalovirus (HCMV) is a major cause of birth defects causing permanent neuronal damage in thousands of infants in the United States every year, and also causes significant disease and death in individuals with weakened immune systems, including transplant recipients and certain cancer patients. New therapeutic options are necessary to block HCMV-associated disease. The immediate goal of our research is to elucidate how HCMV takes control of cellular metabolic resources to ensure successful infection, with the ultimate goal being to use this knowledge to develop novel anti-viral therapeutic interventions.

PI_NAMEs: MUNGER, JOSHUA C (contact)

PROGRAM_OFFICER_NAME: GAUTAM, RAJEEV

PROJECT_TERMS: Address;Anti-viral Agents;antiviral drug development;Attenuated;Biochemical Pathway;Biological Availability;Cancer Patient;cancer transplantation;Cell Death;cell growth regulation;Cells;Cellular Metabolic Process;Cessation of life;Congenital Abnormality;Cytomegalovirus;Cytomegalovirus Infections;Data;Dependence;Disease;Drug resistance;emerging virus;enolase;Ensure;experimental study;Genes;Genetic Transcription;Glucose;Glycolysis Induction;Goals;Hematologic Neoplasms;HIF1A gene;Human;human data;human disease;Human Pathology;Immune system;Immunocompromised Host;Individual;Induced Neurons;Infant;Infection;insight;Isoenzymes;knock-down;Knowledge;Mediating;Metabolic;Metabolic Activation;Metabolic stress;Modeling;Neurons;new therapeutic target;novel;novel therapeutics;Nutrient;Outcome;pathogen;Pathologic;patient population;Process;Production;Productivity;programs;Protein Isoforms;Proteins;Regulation;Research;Resources;response;small hairpin RNA;targeted treatment;Testing;Therapeutic;Therapeutic Intervention;Tissues;Toxic effect;Transplant Recipients;TSC2 gene;Tumor Suppressor Proteins;United States;Viral;Viral Proteins;Virus;Virus Diseases;Virus Replication;Work

PROJECT_TITLE: Metabolic modulation by the HCMV UL38 gene

STUDY_SECTION: VIRB

STUDY_SECTION_NAME: Virology - B Study Section[VIRB]


ED_INST_TYPE: SCHOOLS OF PHARMACY

FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: TUCSON

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: PROJECT NARRATIVE (Overall Core: Maier and Zhang) The University of Arizona Superfund Research Program (UA SRP) addresses the unique human health risks arising from exposure to arsenic in the US Southwest, an area with a rich history and future of mining. Here, disadvantaged mining communities experience several routes of arsenic exposure, and Native American communities in particular exhibit increased diabetes prevalence. Our goal is to build a mechanistic model of the contributions of chronic mine waste-arsenic exposure to the development of diabetes and associated metabolic disease to inform risk assessment tools that can be used to predict exposures and associated health outcomes and to inform public health prevention and interventions in communities that neighbor mine waste sites.

PI_NAMEs: DING, XINXIN  (contact)

PROGRAM_OFFICER_NAME: CARLIN, DANIELLE J

PROJECT_TERMS: Academia;Accounting;Address;Affect;Alaska Native;American Indians;Area;arid land;Arizona;Arsenic;Assessment tool;Awareness;Biological Availability;Chronic;climatic factors;Communication;Communities;community engaged approach;community engaged research;community engagement;Complex;CYP2A5 gene;Data Analyses;data integration;data management;Deposition;design;Development;Diabetes Mellitus;diabetic;diabetogenic;Disadvantaged;Disease;drinking water;Dust;empowerment;Environment;Environmental Health;Exhibits;experience;Exposure to;Future;Genes;Goals;ground water;gut microbiome;Hazardous Waste;Health;hispanic community;Hispanic Populations;Home;Human;Human Resources;Immune response;implementation tool;Incidence;Industry;Ingestion;Inhalation;innovation;Intervention;Knowledge;Link;Measurable;Mediating;Mediation;Metabolic Diseases;Metabolic syndrome;Metals;Mexican Americans;Minerals;Mining;Mission;Modeling;Molecular;Native American community;Native Americans;Not Hispanic or Latino;Outcome;Pathway interactions;Persons;Phenotype;Plants;Policy Maker;Pollution;Prevalence;prevent;Prevention;Prevention strategy;programs;Property;Public Health;Recording of previous events;remediation;Research;Research Project Grants;Risk;Risk Assessment;Risk Factors;Role;Route;Scientist;Severities;Signal Transduction;Site;sociodemographics;Soil;Southwestern United States;success;Superfund;Tail;Technology;Toxic effect;Training;translational engagement;Translational Research;tribal lands;Universities;Vulnerable Populations;wasting;Work

PROJECT_TITLE: Exposures, Health Impacts, and Risk for Mine Waste Contamination


NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

PHR: PROJECT NARRATIVE (Administrative Core; Maier, Zhang, Ramirez-Andreotta, Isaacs) The primary tasks of the University of Arizona Superfund Research Program Administrative Core include guiding our Center as a whole to define the human and environmental health risks associated with metal mining in arid environments. The Administrative Core also leads our Center in the development of innovative, cost-effective, long-term, evidence-based solutions that will effect change in the current mining industry practices and ensure the protection of human health and the environment. The final task of the Administrative Core is to coordinate the communication of Center findings to our stakeholders including NIEHS, our sister Superfund Programs, Federal, State, and Tribal regulatory agencies, the mining industry, and affected communities.

PI_NAMEs: MAIER, RAINA M (contact)

PROJECT_TERMS: Accountability;Address;Affect;Aridity;Arizona;Arsenic;base;Budgets;Cell Nucleus;Collaborations;Communication;Communities;community engagement;Conscience;Contract Services;cost effective;Creativeness;Data;Data Analyses;data management;Decision Making;Dedications;design;Development;disease registry;Education;Ensure;Environment;Environmental Health;Environmental Pollutants;evidence base;experience;Food;Fostering;Future;Glues;Goals;Government Agencies;Grant;Growth and Development function;Hazardous Waste Sites;Health;health disparity;health science research;Human;Human Resources;improved;Indigenous;Individual;Industry;Information Dissemination;innovation;Interdisciplinary Study;International;interoperability;Intervention;investigator-initiated translational research;Leadership;Link;meetings;member;Metals;Mining;Mission;National Institute of Environmental Health Sciences;Periodicals;Poison;Process;programs;Public Health;remediation;Research;Research Personnel;Research Project Grants;Research Support;Resources;Risk;Risk Assessment;role model;Schedule;Security;Signal Recognition Particle;Sister;social health determinants;Southwestern United States;Sum;Superfund;Supervision;Technology;Technology Transfer;Testing;Time;Traineeship;Training;Translating;Translational Research;Translations;tribal community;Tribes;United States Environmental Protection Agency;United States National Institutes of Health;Universities;Vision;Visualization;Voice;waste treatment;wasting;Water;Work

PROJECT_TITLE: Administrative Core


ADMINISTERING_IC: OD

ED_INST_TYPE: OVERALL MEDICAL

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Biotechnology

ORG_CITY: HOUSTON

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: PROJECT NARRATIVE: OVERALL COMPONENT  The “Squirrel Monkey Breeding and Research Resource” (SMBRR) maintains the only self-sustaining national research resource of laboratory-born squirrel monkeys, their tissues and other biological materials, as well as the expertise to carry out research on this important research animal. Scientists with NIH grants utilize squirrel monkeys to study many diseases that threaten human health including Alzheimer's disease and other disorders of the central nervous system, drug addiction, malaria, and viral diseases. The definition and quality of the SMBRR's resources have reduced the number of squirrel monkeys needed, and in some cases, biomaterials from the SMBRR have reduced or eliminated the need for living animals to accomplish research goals.

PI_NAMEs: HOPKINS, WILLIAM D (contact)

PROGRAM_OFFICER_NAME: CONTRERAS, MIGUEL A

PROJECT_TERMS: Address;Adult;Age;Alzheimer's Disease;Animal Experimentation;Animal Model;Animals;Applied Research;Area;Basic Science;Behavior;biobank;Biocompatible Materials;Biological Assay;Biology;Biomedical Research;Blood;Bolivian;brain tissue;Breeding;Caregivers;Caring;Cell Culture Techniques;Cell Separation;Central Nervous System Agents;Central Nervous System Diseases;Characteristics;Classification;Communities;Computer Assisted;computerized;Conceptions;Country;Data Analyses;Data Management Resources;Databases;design;Discipline;Disease;DNA;Doctor of Medicine;Doctor of Philosophy;Drug Addiction;Elderly;epidemiology study;Female;fetal;Foundations;Genetic;genetic analysis;genetic pedigree;Genome;Genomics;Goals;Grant;gut microbiome;gut microbiota;Health;Human;Immunology;improved;Inbreeding;Individual;Intramural Research Program;Laboratories;Language;Lead;learning strategy;Malaria;Malaria Vaccines;Maps;Medical History;Medical Records;meetings;Memory;Modeling;Monitor;monocyte;Neurosciences Research;novel strategies;Perinatal mortality demographics;Phagocytosis;Pharmacologic Substance;Phenotype;Population;Population Genetics;Privatization;programs;reproductive;Research;Research Contracts;Research Personnel;Research Project Grants;Resources;Saimiri;Scientist;Services;sex;social group;Source;symposium;System;Taxonomy;Technology;Testing;Tissues;tool;Training;Training and Education;training opportunity;trait;United States National Institutes of Health;Vaccine Research;Virus Diseases;Work

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-GGG-D(50)R]


NIH_SPENDING_CATS: Bioengineering;Data Science;Networking and Information Technology R&D (NITRD)

PHR: PROJECT NARRATIVE (Data Management and Analysis Core: Aikseng Ooi and Nirav Merchant)  Understanding the roles of arsenic in complex diseases like diabetes requires an integrated approach that  combines vast quantities of information from multiple fields, including biomedical science, geology, and  environmental science. The Data Management and Analysis Core serves as the primary storage and analytical  service for the data generated from various experiments investigating arsenic toxicity. DMAC builds upon the  CyVerse infrastructure and utilizes state-of-the-art hardware, software, and analytics to merge the findings of  various scientific disciplines into new multifaceted insights.

PI_NAMEs: OOI, AIKSENG  (contact)

PROJECT_TERMS: Address;Algorithms;Analytical Chemistry;Architecture;Arizona;Arsenic;Bar Codes;Biological;case-by-case basis;Chemicals;ChIP-seq;Code;Collaborations;Communication;Communities;community engagement;Complex;Complex Analysis;Computer Analysis;computer infrastructure;Computer software;computerized tools;Custom;Data;data access;Data Analyses;data format;data integration;data management;data repository;Data Set;data sharing;Data Storage and Retrieval;data tools;data visualization;design;Diabetes Mellitus;Discipline;Disease;diverse data;Educational workshop;empowerment;Environment;Environmental Science;exome sequencing;experience;experimental group;experimental study;file format;Funding;Future;Gene Expression;Generations;genetic signature;Genomics;Geology;Goals;graphical user interface;Health;Housing;Human Resources;Image;Individual;Industry;Infrastructure;innovation;insight;interest;Intuition;Investigation;Laboratories;large datasets;Lead;Libraries;Mass Spectrum Analysis;member;metabolomics;metagenome;Metagenomics;microbiome;mobile computing;novel;NUP214 gene;Plants;Positioning Attribute;prediction algorithm;Prediction of Response to Therapy;Process;Program Research Project Grants;programs;Proteomics;public repository;Publishing;Research;Research Activity;Research Personnel;Research Project Grants;Risk;Role;Running;Sampling;Science;Services;skills;Soil;Standardization;Stratification;Superfund;System;Technology;Testing;tool;Toxic effect;Training;transcriptome sequencing;Translational Research;Translations;United States National Institutes of Health;Universities;user-friendly;Visualization;wasting;web app;Work

PROJECT_TITLE: Data Management and Analysis Core


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cannabinoid Research;Chronic Pain;Dementia;Mental Health;Neurodegenerative;Neurosciences;Pain Research;Prevention;Substance Misuse

ORG_CITY: DURHAM

ORG_DEPT: PSYCHOLOGY

ORG_NAME: DUKE UNIVERSITY

PHR: PROJECT NARRATIVE Many babyboomers who began using cannabis as young people, and who have continued use for years, are now entering later life, and NIA and NIDA have called for research on the implications of cannabis use for the health and well-being of this group of adolescent-onset persistent-to-midlife cannabis users. The project will generate new evidence about the impact of life-long use of cannabis on cognitive reserves, neural reserves, financial reserves, epigenetic- maintenance reserves, the biological aging process, and on potential risk for disease, including Alzheimer’s disease and related disorders. The proposed work will yield the first comprehensive portrait of how well midlife long-term cannabis users are prepared for old age.

PI_NAMEs: MOFFITT, TERRIE E (contact)

PROGRAM_OFFICER_NAME: BANDIERA, FRANK

PROJECT_TERMS: 3-Dimensional;Adolescent;Adult;Age;age acceleration;age-related disease;Aging;aging brain;aging process;alcohol abuser;Algorithms;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Anxiety;Area;Attention deficit hyperactivity disorder;baby boomer;Biological Aging;Biological Markers;Blood;Body System;Brain;brain abnormalities;Cannabis;cannabis use behavior;Cardiovascular system;Childhood;Cities;Clinical;Cognitive;cognitive ability;cognitive reserve;cognitive testing;cohort;Computerized Medical Record;convict;cost;Data;Data Analyses;Data Set;Development;Dimensions;Discipline;Disease;disorder risk;DNA Methylation;Drug Prescriptions;epigenetic clock;Epigenetic Process;experience;financial literacy;Future;genome-wide;Government;gray matter;Headache;Health;healthspan;Hepatic;human old age (65+);immune function;Individual;Individual Differences;Infant;Injury;innovation;insurance claims;interest;Interest Group;Interview;Kidney;late life;Life;Logic;low health literacy;Lung;Magnetic Resonance Imaging;Maintenance;Marijuana Dependence;marijuana use;marijuana user;Measures;Mediation;medical examination;member;Mental Depression;Mental Health;Metabolic;Methods;Methylation;middle age;Modeling;mortality;Motor;Musculoskeletal Pain;National Institute of Drug Abuse;neural;neuroimaging;Neuropsychology;novel;older adult;Pain;Participant;Personal Satisfaction;Persons;physical conditioning;physical inactivity;Portraits;Positioning Attribute;Prevention;prospective;Prospective Studies;Publications;Publishing;Quality of life;rate of aging;Recording of previous events;Records;Recreation;Research;Risk;Sampling;Savings;Secure;Services;Sleep;sleep quality;socioeconomics;Structure;Surface;Taxes;Testing;Thick;tobacco smokers;welfare;white matter;White Matter Hyperintensity;whole genome;Work

PROJECT_TITLE: Comprehensive portrait of long-term cannabis users: Are they ready for old age?

STUDY_SECTION: ARM

STUDY_SECTION_NAME: Addiction Risks and Mechanisms Study Section[ARM]


NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

PHR: PROJECT NARRATIVE (Community Engagement Core: Chief, Rainie, Maier)  The University of Arizona Superfund Research Program (UA SRP) Community Engagement Core (CEC) will  utilize community-based participatory research to address increased exposure to arsenic and the impact of  exposure on metabolic diseases, particularly diabetes risk, in Native American communities living near mining  sites. Recent evidence suggests that Native American communities are disproportionately impacted by mining  and arsenic contaminated water, resulting in increased rates of diabetes in Native Americans. The tools  developed by the UA SRP CEC will be used for multi-lateral communications with Native American communities  to enable these vulnerable populations to make informed decisions on health issues related to mining, arsenic  contamination, and remediation efforts.

PI_NAMEs: CHIEF, KARLETTA  (contact)

PROJECT_TERMS: 20 year old;active lifestyle;Address;Affect;Arctic Regions;Arizona;Arsenic;Awareness;Bilateral;Centers for Disease Control and Prevention (U.S.);Coal;college;Colorado;Communication;Communication Tools;Communities;community academic partnership;community based participatory research;community building;community college;Community Developments;community empowerment;community engaged research;community engagement;Community Health;community living;contaminated water;cultural values;Data;Data Analyses;data management;design;Development;Diabetes Mellitus;diabetes risk;Diagnosis;Diné Nation;Education;Education and Outreach;Educational process of instructing;Educational workshop;efficacy evaluation;empowerment;Ensure;Environment;Environmental Health;Environmental Impact;epidemiology study;experience;Exposure to;Farm;Food;Fostering;Gases;General Population;Goals;good diet;graduate student;Health;health literacy;health training;Home;Indigenous;Individual;innovation;Intervention;Knowledge;knowledge network;Lateral;Learning Module;Marketing;meetings;member;Metabolic Diseases;Mining;Multilingualism;National Institute of Environmental Health Sciences;Native American community;Native American population;Native Americans;Navajo;Oils;Outcomes Research;outreach;Pamphlets;Politics;Population;Prevention strategy;Problem Solving;Process;Program Research Project Grants;programs;Race;remediation;Reporting;Research;Research Personnel;Risk;Risk Factors;risk minimization;Schools;Science;Site;skills;Social Responsibility;success;Superfund;Technology;therapy development;Tohono O'odham;tool;Training;Training and Education;Training Programs;Translating;tribal college;tribal community;tribal lands;Tribes;Trust;Universities;Uranium;vulnerable community;Vulnerable Populations;wasting;Water;Work

PROJECT_TITLE: Community Engagement Core


PROJECT_TERMS: Address;Affect;apprenticeship;Arizona;Arsenic;Award;Awareness;Biological Availability;career;cohort;Communication;Communities;community engaged research;community engagement;Community Health;Community Outreach;community research;Complex;Data;Data Analyses;data management;Data Set;Development;Discipline;Education;Educational Curriculum;Elements;Eligibility Determination;Ensure;Environment;Environmental Health;Environmental Science;Ethics;experience;Exposure to;General Population;Goals;Government;graduate student;gut microbiome;Hazardous Waste;Health;Human;improved;In Vitro;in vivo Model;Industry;innovation;interdisciplinary collaboration;Language;Link;meetings;Mentors;Metals;Mining;Mission;Organ;particle;Pathology;Personal Satisfaction;Positioning Attribute;Postdoctoral Fellow;Production;Program Research Project Grants;programs;Research;Research Activity;Research Project Grants;Resources;responsible research conduct;Risk;Science;Scientist;skills;social;Social Responsibility;student training;Students;success;Superfund;Tail;Testing;Tissues;Toxic effect;Training;training opportunity;translational engagement;Translational Research;Translations;undergraduate student;Universities;wasting

PROJECT_TITLE: Research Experience and Training Coordination Core


NIH_SPENDING_CATS: Aging;Assistive Technology;Atherosclerosis;Bioengineering;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Heart Disease;Heart Disease - Coronary Heart Disease;Patient Safety;Precision Medicine;Transplantation

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: PROJECT NARRATIVE As the population ages, identifying the patients with heart disease who will benefit most from more aggressive treatment, and which others might do better with more conservative care, is critically important to improving public health. In this proposal, we will combine different data sources for patients who underwent aortic valve replacement or coronary artery stent procedures to determine whether and how frail elderly patients should be treated differently than non-frail patients. Using this information, we will develop and implement tools that can help patients and their clinicians select treatment strategies that are most aligned with their preferences and appropriate for their health condition.

PI_NAMEs: YEH, ROBERT  (contact)

PROGRAM_OFFICER_NAME: REDMOND, NICOLE

PROJECT_TERMS: Accounting;adverse event risk;Age;aggressive therapy;alternative treatment;aortic valve;aortic valve replacement;Aortic Valve Stenosis;Aspirin;Blood Platelets;Cardiovascular Diseases;Cardiovascular system;career;Caring;Characteristics;Clinical Trials;Communities;comorbidity;Coronary;Coronary Arteriosclerosis;Coronary artery;Data;Data Collection;data registry;Data Set;Data Sources;Decision Aid;Decision Making;Development;Evaluation;evidence base;Faculty;Frail Elderly;frailty;Funding;Grant;hazard;Health;Health system;Heart Diseases;Hemorrhage;Heterogeneity;high risk;Hospitals;improved;indexing;Individual;individual patient;individualized medicine;inhibitor;insight;Knowledge;Laboratories;Life;Link;Measurement;Measures;Medical;Medicare claim;Mentors;Mid-Career Clinical Scientist Award (K24);minimally invasive;Morbidity - disease rate;mortality;Myocardial Infarction;National Heart, Lung, and Blood Institute;novel;Observational Study;older patient;Operative Surgical Procedures;Outcome;Participant;participant enrollment;patient oriented research;Patients;personalized approach;personalized decision;Physiological;point of care;Population;preference;Procedures;prognostic;programs;prospective;Public Health;Quality of life;randomized trial;Recommendation;Registries;Research;research clinical testing;Research Personnel;Research Support;Risk;Risk Estimate;Risk Factors;risk stratification;shared decision making;Source;stent thrombosis;Stents;stressor;Stroke;Subgroup;Talents;therapy duration;tool;Training;Translating;treatment effect;Treatment outcome;treatment strategy;Work

PROJECT_TITLE: Using Claims-Based Signatures of Frailty to Support Individualized Treatment of Aortic Valve Stenosis and Coronary Artery Disease

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(OA)]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: PROJECT NARRATIVE Metabolic diseases, such as diabetes and obesity, are costly chronic diseases and affect millions of individuals in the USA leading to significant morbidity and mortality. By using experimental mouse models and in vitro cellular assays, we will determine the mechanisms by which a G-protein coupled receptor in gastrointestinal tissue regulates energy and glucose homeostasis. This study will shed a light into the molecular pathways that mediate nutrient sensing and hormone secretion in the gut, which may provide therapeutic potentials to treat diabetes and obesity.

PI_NAMEs: REN, HONGXIA  (contact)

PROGRAM_OFFICER_NAME: CUMMINGS, DIANA M

PROJECT_TERMS: Address;Affect;Agonist;antagonist;Appetite Stimulants;bariatric surgery;Behavior;blood glucose regulation;Body Composition;Body Weight;Brain;Calcium;Cell Physiology;Cells;Cellular Assay;Chronic Disease;Closure by clamp;common treatment;cost;Couples;Cyclic AMP;Data;detection of nutrient;Development;Diabetes Mellitus;druggable target;Endocrine;energy balance;Enteroendocrine Cell;euglycemia;Exhibits;Fasting;feeding;Food;Foundations;Future;G-Protein-Coupled Receptors;gastric inhibitory polypeptide receptor;gastrointestinal;gastrointestinal epithelium;Gastrointestinal tract structure;glucagon-like peptide 1;Glucose;glucose metabolism;glucose tolerance;Goals;GPR17 gene;Graph;gut-brain axis;Hormone secretion;Hormones;Human;Hyperinsulinism;imaging system;improved;In Vitro;in vivo Model;incretin hormone;Individual;Ingestion;Insulin;Insulin Resistance;insulin sensitivity;insulin signaling;intestinal epithelium;Intestines;Knock-out;Knockout Mice;lifestyle intervention;Ligands;live cell imaging;Measures;Mediating;Mediator;Metabolic;Metabolic Diseases;Modeling;Molecular;Morbidity - disease rate;mortality;Motility;mouse model;Mus;neuromechanism;new therapeutic target;novel;novel therapeutics;Nutrient;Obesity;Operative Surgical Procedures;Organ;Organoids;Orphan;Pathway interactions;Pattern;Pertussis Toxin;Phenotype;Physiological;Physiology;Production;reduced food intake;Regulation;Resolution;response;Risk;Rodent;Role;Satiation;sensory system;Signal Transduction;spatiotemporal;Stimulus;Stomach;Testing;Therapeutic;therapeutic target;Tissues;United States;Work

PROJECT_TITLE: Metabolic Function of Gpr17 in Gastrointestinal Tract

STUDY_SECTION: MCE

STUDY_SECTION_NAME: Molecular and Cellular Endocrinology Study Section[MCE]


PHR: PROJECT NARRATIVE (Project 1: Donna Zhang) Millions of people are chronically exposed to arsenic, increasing their risk of developing metabolic diseases such as diabetes. Currently, the molecular mechanisms by which arsenic promotes diabetes are not known. Our goal for this project is to investigate the molecular mechanisms by which arsenic alters cellular responses and to achieve a mechanistic understanding of the arsenic-mediated pathophysiologic alterations that lead to diabetes, enabling the generation of diagnostic, preventive, and therapeutic strategies for populations exposed to As-containing mine tailings and at risk of arsenic exposure.

PI_NAMEs: ZHANG, DONNA D (contact)

PROJECT_TERMS: 26S proteasome;Adipocytes;Antioxidants;Arsenic;Attenuated;Automobile Driving;Autophagocytosis;Autophagosome;Beta Cell;biomarker identification;Blood;Cell Line;cell type;Cholesterol;Cholesterol Homeostasis;Chronic;coarse particles;Communities;contaminated drinking water;CRISPR/Cas technology;Critical Pathways;CYP2A5 gene;Darkness;Data;Data Analyses;data management;Degradation Pathway;Dependence;Diabetes Mellitus;diabetic;Diabetic Nephropathy;diabetogenic;Diagnostic;diagnostic development;disease registry;disorder risk;Dose;drinking water;Ensure;Environment;epidemiology study;Exposure to;Extracellular Matrix;fatty acid metabolism;ferrihydrite;Food;Food Contamination;Functional disorder;Gene Expression;Generations;Genes;Genomics;Glucose;glucose tolerance;Goals;gut microbiome;Hazardous Substances;Health;Hepatocyte;high risk;impaired glucose tolerance;in vivo;in vivo Model;Incidence;Ingestion;Inhalation;Insulin;Insulin Resistance;insulin signaling;Kidney;knowledge base;Link;lipid biosynthesis;lipid metabolism;Liver;Measures;Mediating;mesangial cell;Metabolic;Metabolic Diseases;metabolomics;Metals;microbiome alteration;Modification;Molecular;Mus;Myoblasts;Obesity;Outcome;particle;Pathway interactions;Persons;Phenotype;Poison;Population;Populations at Risk;Preventive;Production;Proteins;Proteomics;proteostasis;Reporting;response;Risk;Role;Severities;Side;Site;sodium arsenite;Soil;System;Tail;Testing;Therapeutic;Therapeutic Intervention;Time;Tissues;toxic metal;transcription factor;transcriptome sequencing;transcriptomics;Triglyceride Metabolism;Triglycerides;Ubiquitination;Up-Regulation;Urine;wasting;Water;Wild Type Mouse

PROJECT_TITLE: Diabetogenic Mine Tailings: Mechanistic Link Between Arsenic, NRF2, Autophagy, and Diabetes


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Nutrition;Obesity;Prevention

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Obesity is a significant public health concern associated with an overall increased risk of cardiovascular disease, type 2 diabetes, and mortality. The overall goals of this project are to determine the impact of an implicit priming intervention, designed to alter food perceptions, on brain responses to food, food intake behaviors and weight-loss maintenance in individuals with overweight/obesity. If the aims of the project are achieved, it would not only yield new information about the neurobiology of food intake behavior, but also could represent a potential novel intervention for treatment and prevention of obesity.

PI_NAMEs: TREGELLAS, JASON R (contact)

PROGRAM_OFFICER_NAME: MARUVADA, PADMA

PROJECT_TERMS: active control;Acute;Affective;Association Learning;Attention;Attitude;Behavior;behavior change;behavior measurement;Behavioral;behavioral response;behavioral study;Body Composition;Body Weight decreased;Brain;Calories;cardiovascular disorder risk;Chronic;Cognitive;Complex;conditioning;Consumption;Cues;Data;design;Desire for food;Eating;Eating Behavior;Emotional;energy balance;Energy Intake;Fatty acid glycerol esters;Food;food craving;Food Preferences;Funding;Goals;Health;hedonic;Hormones;Ice Cream;Image;improved;Individual;Insula of Reil;Intake;Intervention;intervention effect;Investigation;Learning;Maggots;Maintenance;Measures;men;mortality;Negative Valence;Neurobiology;neuroimaging;Neurons;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;obesity prevention;Overweight;Participant;Patient Self-Report;Perception;Pilot Projects;Positive Valence;Predisposition;preference;Prefrontal Cortex;prevent;Process;Property;Public Health;Quality of life;Radio;Randomized;recruit;Regulation;Research;response;Rewards;Risk;Risk Factors;Sensory;Sex Differences;Signal Transduction;Stimulus;Strategic Planning;therapy design;United States National Institutes of Health;Ventral Striatum;Visual;Washington;Weight;weight loss program;weight maintenance;Woman;women versus men

PROJECT_TITLE: Neuronal and behavioral effects of an implicit priming approach to improve eating behaviors in obesity

STUDY_SECTION: CIDO

STUDY_SECTION_NAME: Clinical and Integrative Diabetes and Obesity Study Section[CIDO]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Sleep Research

ORG_CITY: TALLAHASSEE

ORG_NAME: FLORIDA STATE UNIVERSITY

ORG_STATE: FL

PHR: PROJECT NARRATIVE The focus of this research is on the sleep related function of a brain network that is affected by Tau and amyloid beta deposition in Alzheimer’s disease and the relationship between these functional changes and impaired memory in Alzheimer’s disease. This research is relevant to public health because it will increase knowledge about the role of changes in the functional interactions between the cortex and hippocampus and use current technologies to perform a functional dissection of Tau and amyloid beta clearance in these critical brain circuits, including a noninvasive approach for clearing tau and amyloid beta. The proposal is relevant to NIH’s mission in that it will expand the knowledge base, and establish a new research platform for understanding the mechanism of impaired memory in Alzheimer’s disease.

PI_NAMEs: WILBER, AARON A (contact)

PROGRAM_OFFICER_NAME: MACKIEWICZ, MIROSLAW

PROJECT_TERMS: 3xTg-AD mouse;abeta accumulation;Abeta clearance;abeta deposition;Affect;Age;Alzheimer's Disease;Alzheimer's disease model;Amyloid beta-Protein;Amyloid deposition;Animal Model;animal old age;Behavior;Brain;brain abnormalities;brain dysfunction;Cells;cellular pathology;Code;cognitive change;Communication;Coupling;Detection;Disease;Disease Progression;Dissection;early detection biomarkers;Early treatment;efficacy testing;Episodic memory;Exhibits;experience;extracellular;familial Alzheimer disease;forgetting;Functional disorder;Genes;Head;Hippocampal Formation;Hippocampus;Histology;Human;hyperphosphorylated tau;Impaired cognition;Impairment;improved;Individual;insight;Interneurons;juvenile animal;Knowledge;knowledge base;Learning;Light;Limbic System;Link;Memory;memory acquisition;memory consolidation;Memory impairment;Mission;mouse model;Mus;neural;Neurofibrillary Tangles;novel;optogenetics;Parietal Lobe;Parvalbumins;Pathologic;Pathology;Patients;Pattern;Performance;Phase;Photic Stimulation;potential biomarker;pre-clinical;prevent;Process;protein aggregation;Public Health;Pyramidal Cells;Rat Transgene;Research;Rest;Rodent;Rodent Model;Role;Series;Sleep;Sleep disturbances;Slow-Wave Sleep;Societies;spatial memory;spatiotemporal;Symptoms;Synapses;tau aggregation;tau Proteins;tau-1;Technology;Testing;theories;Transgenic Mice;United States National Institutes of Health;Visual;Visual Cortex;way finding

PROJECT_TITLE: Cortical-hippocampal brain dynamics during sleep following spatial learning in rodents modeling Tau and AB aggregation feature of Alzheimer's disease

STUDY_SECTION: CDIN

STUDY_SECTION_NAME: Chronic Dysfunction and Integrative Neurodegeneration Study Section[CDIN]


NIH_SPENDING_CATS: Diabetes;Digestive Diseases;Endocrine Disruptors;Foodborne Illness;Microbiome;Nutrition;Prevention

PHR: PROJECT NARRATIVE (Project 2: Xinxin Ding and Qing-Yu Zhang)  Environmental exposure to arsenic metalloids contained in mine tailings poses a significant health risk to people  living near contaminated sites, as the arsenic contaminants may become bio-accessible and cause debilitating  metabolic diseases such as diabetes. Validation of our hypothesis that the induction of intestinal Hmox1 and  hepatic CYP2A5/6 serves as an important counterbalance against the diabetogenic effects of chronic mine tailing  arsenic exposure will provide the foundation for development of novel approaches for disease prevention for  people who live in contaminated areas.

PROJECT_TERMS: 7alpha hydroxylase;Antioxidants;Area;Arsenic;Arsenicals;Autophagocytosis;Bile Acids;Bilirubin;Blood;Chronic;Clinical;coarse particles;contaminated water;Crossbreeding;CYP2A5 gene;Data;Data Analyses;data management;Detection;Development;Diabetes Mellitus;diabetic;Diabetic Nephropathy;diabetogenic;Disease;disorder prevention;drinking water;Dust;Environment;Environmental Exposure;Enzymes;Event;Exposure to;Feces;Female;ferrihydrite;FGF21 gene;Fibroblast Growth Factor;fibroblast growth factor 21;Food;Foundations;Genes;glucose tolerance;gut microbiome;Health;heme oxygenase-1;Hepatic;Homeostasis;Human;Incidence;Ingestion;Inhalation;Insulin Resistance;Intestinal Content;intestinal epithelium;Intestines;Knockout Mice;Knowledge;Liver;male;Mediating;Metabolic;Metabolic Biotransformation;Metabolic Diseases;Metabolic syndrome;Metabolism;Metagenomics;microbial;microbiome composition;Mining;Modification;Molecular;Mus;Non-Insulin-Dependent Diabetes Mellitus;novel;novel strategies;Obesity;Oral;Outcome;particle;Particulate;Pathway interactions;Persons;Phenotype;Play;Population;prevent;Production;response;Risk;Risk Factors;Role;Serum;Signal Transduction;Site;sodium arsenite;stool sample;Tail;Testing;Tissue Sample;Tissues;Transgenic Organisms;Triglycerides;Urine;Validation;villin;wasting;Weaning

PROJECT_TITLE: Role of CYP2A and Hmox1 in the Diabetogenic Effects of Arsenic in Mine Tailings


NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Clinical Research;Genetics;Heart Disease;Human Genome;Pediatric;Pediatric Cardiomyopathy;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: PROJECT NARRATIVE Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiovascular disease with substantial morbidity and mortality, and the leading cause of sudden cardiac death in young people, for which, yet no effective treatment is available, and the etiologies for 40-70% of cases are not known. My studies suggested a role for non-coding variants in pathogenesis of unexplained HCM. In this proposal, I will apply multiple methods including whole genome sequencing, RNA sequencing and induced pluripotent stem cells (iPSCs) modeling to investigate the role of non-coding variants, and uncover novel HCM genes and their pathogenic mechanisms for novel diagnostics and therapeutic intervention, thereby improving care and reducing medical costs for patients.

PI_NAMEs: HAGHIGHI, ALIREZA  (contact)

PROGRAM_OFFICER_NAME: NEILSON, KAREN MARY

PROJECT_TERMS: Advisory Committees;Age;Alleles;Award;Bioinformatics;Blood;Candidate Disease Gene;Cardiac;Cardiac Myocytes;Cardiology;Cardiomyopathies;Cardiovascular Diseases;Cardiovascular system;career;career development;Caring;Childhood;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Code;Collaborations;Computational Biology;Data;differential expression;Disease;disease model;disease-causing mutation;DNA;dominant genetic mutation;Early Diagnosis;Early identification;effective therapy;Energy consumption;Environment;epigenomics;Etiology;Exclusion;Exhibits;exome sequencing;experimental study;Extramural Activities;Five-Year Plans;Foundations;Funding;Future;Gene Expression;gene function;Genes;Genetic;Genetic Predisposition to Disease;genetic variant;genome sequencing;Genomics;Goals;Grant;Health;Heart;Heart Transplantation;Heterozygote;Hospitals;Human;Human Genetics;human induced pluripotent stem cells;Hypertrophic Cardiomyopathy;improved;in silico;Individual;induced pluripotent stem cell;induced pluripotent stem cell derived cardiomyocytes;Inherited;insight;instructor;Investigation;Laboratory Organism;Left ventricular structure;loss of function;Loss of Heterozygosity;Medical Care Costs;medical schools;Medicine;Mentors;Mentorship;Methods;model organism;Modeling;Molecular;Morbidity - disease rate;mortality;mutant;Mutation;mutation carrier;National Heart, Lung, and Blood Institute;novel;novel diagnostics;novel therapeutic intervention;Null Lymphocytes;Online Mendelian Inheritance In Man;Onset of illness;Pathogenesis;Pathogenicity;Pathway interactions;Patient Care;Patients;Persons;Phenotype;Physiology;Prevalence;proband;protein function;Proteins;rare variant;Relaxation;Research;research and development;Research Personnel;RNA Splicing;Role;Sarcomeres;Scientist;skills;Solid;Somatic Mutation;Spliced Genes;statistics;stem cell model;sudden cardiac death;Sudden Death;symposium;Tissue Sample;Tissues;Training;Trans-Omics for Precision Medicine;transcriptome sequencing;Translating;Untranslated RNA;Variant;variant of unknown significance;whole genome;Woman

PROJECT_TITLE: Discovery of Novel Genetic Variants Underlying Unexplained Hypertrophic Cardiomyopathy by Whole Genome Sequencing, RNA-seq and iPSC modeling

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(OA)]


NIH_SPENDING_CATS: Microbiome;Nutrition;Prevention

PHR: NARRATIVE (Project 3: Pawel Kiela, Paul Carini, and Albert Barberán)  Arsenic ingestion has been associated with diabetes, numerous cancers and cardiovascular disorders.  Biotransformation of oral arsenic ingestion by the gut microbiome has potential to modulate the arsenic-load  experienced by the host, and thus, must be incorporated into the risk assessment of arsenic ingestion.  Microbial communities that reduce presystemic arsenic-toxicity can be exploited as potential probiotics to  reduce negative health outcomes that are associated with chronic arsenic exposure.

PI_NAMEs: KIELA, PAWEL R (contact)

PROJECT_TERMS: Activities of Daily Living;Address;Affect;Age;Anti-diabetic Drugs;Arsenic;Arsenicals;Arsenites;Cardiovascular Diseases;Chronic;Collaborations;colon microbiota;Communities;cytotoxic;design;Diabetes Mellitus;diabetic;dietary;Drug Metabolic Detoxication;Economics;Ecosystem;experience;exposure route;Fermentation;Future;Genes;Genetic;germ free condition;Germ-Free;gut microbiome;gut microbiota;Health;Health Hazards;Human;In Vitro;in vivo;Ingestion;Knowledge;Malignant Neoplasms;Mediating;Metabolic Biotransformation;Metabolic Pathway;metabolic profile;Metabolism;metagenome;Metals;Methylation;microbial;microbial community;Microbial Taxonomy;microbiome;microbiota;Molecular Analysis;multidisciplinary;Mus;Oral;Oral Ingestion;Orthologous Gene;Outcome;Population;prevent;Probiotics;Property;resistance gene;response;Risk;Risk Assessment;rRNA Genes;sex;Shotguns;sodium arsenite;Soil;stool sample;Symptoms;synthetic construct;Tail;Testing;Toxic effect;wasting;western diet

PROJECT_TITLE: Microbial Contributions to Arsenic Transformation in the Gut


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Genetics;HIV/AIDS;Infectious Diseases;Rare Diseases;Tuberculosis

ORG_CITY: IRVINE

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

ORG_STATE: CA

PHR: PROJECT NARRATIVE  Poor understanding of tuberculosis (TB) transmission limits the effectiveness current efforts to end the global TB epidemic. We will use advanced molecular methods that account for multiple M. tuberculosis strains within an individual with TB disease to improve the understanding of TB dynamics and more precisely identify TB hotspots. If successful, information from our study could be used to significantly improve the effectiveness of TB interventions in various settings worldwide.

PI_NAMEs: SHIN, SANGHYUK SAM (contact)

PROGRAM_OFFICER_NAME: MAHON III, ROBERT N

PROJECT_TERMS: Accounting;Affect;Area;Bioinformatics;Botswana;case finding;Categories;Cessation of life;Church;Cluster Analysis;co-infection;Cohort Studies;Collaborations;combat;Communities;Data;Detection;detection method;Development;Disease;DNA;Effectiveness;Enrollment;Epidemic;epidemiologic data;Epidemiology;epidemiology study;Exclusion;Future;Genetic;genome sequencing;genomic locus;Genotype;Goals;Heterogeneity;High Prevalence;HIV;HIV Infections;HIV/TB;Household;improved;Incidence;indexing;Individual;Infection;Integration Host Factors;Interruption;Intervention;Knowledge;Methods;Modeling;Molecular;Molecular Analysis;Molecular Epidemiology;Molecular Profiling;Morbidity - disease rate;mortality;multimodality;Mutation;Mycobacterium tuberculosis;Mycobacterium tuberculosis complex;Natural History;novel;pathogen;Pathogen detection;Persons;Phylogenetic Analysis;Population;population based;Predictive Factor;Predisposition;Prevalence;prospective;Public Health;Research;Research Infrastructure;Resistance;resistance mutation;response;Sampling;Sampling Biases;social;Source;Sputum;statistical learning;transmission process;Tuberculosis;whole genome

PROJECT_TITLE: Improved understanding of TB transmission by accounting for within-host heterogeneity of M. tuberculosis: A population-based molecular epidemiology study in a high HIV prevalent setting

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDM-R(50)R]


NIH_SPENDING_CATS: Prevention

PHR: PROJECT NARRATIVE (Project 4: Jon Chorover and Mark Brusseau) Ingestion of airborne particulate matter represents a significant human health risk, particularly when the particles are derived from mine tailings sites with elevated concentrations of arsenic and associated toxic metals, including lead and zinc. This project will investigate the processes whereby tailings undergo weathering-induced changes in toxic metal(loid) speciation and bioaccessibility. The outcomes of the proposed project will enable the determination of the mechanistic links between grain-scale weathering reactions, field- scale reactive transport processes, and associated risk to nearby communities.

PI_NAMEs: CHOROVER, JON D (contact)

PROJECT_TERMS: Affect;Airborne Particulate Matter;Arsenic;Biological Assay;Biological Availability;Bioreactors;Chemicals;Climate;Collection;Communities;cost effective;Coupled;Data;data management;Data Set;Deposition;Development;Dose;Elements;Environment;Evolution;Exhibits;Experimental Designs;experimental study;Exposure to;fluid flow;Forensic Medicine;Gases;geochemistry;Grain;Health;health assessment;Heterogeneity;Human;improved;in vitro Bioassay;in vivo;Ingestion;Inhalation;instrument;Kinetics;Laboratories;Lead;Length;Link;Liquid substance;Measures;Medial;Metal exposure;metal poisoning;Metals;Methods;microbial;microbial composition;Minerals;Modeling;Molecular;Organism;Outcome;Parents;particle;Pathway interactions;Phase;Planet Earth;Porosity;predictive tools;Process;Property;Reaction;reaction rate;receptor;residence;Risk;Risk Assessment;Sampling;Site;Soil;Solid;Source;Stomach;Structure;Sulfides;superfund site;Surface;Tail;Techniques;Time;Toxic effect;toxic metal;toxicant;Transport Process;trend;wasting;Water;Work;Zinc

PROJECT_TITLE: Environmental Controls on Bioavailability of Arsenic and Toxic Metals


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Cardiovascular;Clinical Research;Heart Disease;Hypertension;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Physical Activity;Prevention

ORG_CITY: SAN JOSE

ORG_DEPT: MISCELLANEOUS

ORG_NAME: SAN JOSE STATE UNIVERSITY

PHR: PROJECT NARRATIVE  This project aims to elucidate the pathophysiological basis for the higher prevalence of hypertension and cardiovascular disease in individuals with Autism Spectrum Disorder (ASD). We proposed to investigate 1) whether heightened sympathetic nervous system activity is a major contributor to augmented blood pressure during exercise in ASD; it is caused by impaired exercise pressor reflex activation, 2) how sympathetically mediated vascular responses contribute to the blood pressure increase during exercise in ASD, and 3) whether impaired arterial baroreflex function causes exaggerated sympathetic nervous system activity during exercise in ASD. With guidance from SC2 mentors who have expertise in clinical applications of autonomic function and exercise testing and training in health and disease, this study will begin to identify pathophysiology of early hypertension and CVD in individuals with ASD and will form the basis for future experimental and clinical studies to determine an effective therapeutic target, enable improved patient care, and ultimately enhance the quality of life for individuals with ASD.

PI_NAMEs: JENSEN, AREUM KIM (contact)

PROGRAM_OFFICER_NAME: BERNAL, FEDERICO

PROJECT_TERMS: Acceleration;Acute;Adolescent and Young Adult;Attenuated;autism spectrum disorder;autistic children;Autonomic Dysfunction;Baroreflex;Blood flow;Blood Pressure;blood pressure control;blood pressure elevation;blood pressure reduction;blood pressure regulation;blood pressure variability;Blood Vessels;Brain Stem;Buffers;Cardiac Output;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;Cardiovascular system;Centers for Disease Control and Prevention (U.S.);Chemicals;Child;Childhood;Chronic;clinical application;clinical efficacy;Clinical Research;comparison control;Contracts;Data;Development;Disease;effective therapy;Exercise;Exercise Test;exercise training;experience;experimental study;Functional disorder;Functional impairment;Future;General Population;Goals;Health;Heart Abnormalities;Heart Diseases;Heart Rate;High Prevalence;Hyperactivity;Hypertension;Impairment;improved;Individual;individuals with autism spectrum disorder;Intervention;Ischemia;Measures;Mechanics;Mediating;Mentors;mortality;Muscle;Muscle Fibers;Neck;Nerve;neural;neuromechanism;neuroregulation;Norepinephrine;Outcome;Patient Care;Periodicity;peroneal nerve;Plasma;Population;pressure;prevent;Quality of life;Reflex action;response;Rest;restraint;Risk;Risk Reduction;Role;Skeletal Muscle;Stroke;Structural defect;Sympathetic Nervous System;Techniques;therapeutic target;therapeutically effective;Time;Vascular resistance;vasoconstriction;Vasoconstrictor Agents;young adult with autism spectrum disorder

PROJECT_TITLE: The Role of Sympathetic Nervous System Activity on Blood Pressure Regulation in Individuals with Autism Spectrum Disorder


NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: Narrative: Fundamental and applied studies of nucleic acids For 30 years the Maher laboratory has been studying how the DNA and RNA molecules in cells work, and how they can be used as tools to do new things. We are learning how these molecules ﬁt inside cells, and how collections of trillions of random DNA and RNA molecules can be used as raw material to discover new drugs. Support for the work of the Maher laboratory promises important new discoveries across a range of ﬁelds, and a challenging research environment ideal for training students.

PI_NAMEs: MAHER, LOUIS JAMES (contact)

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TERMS: Address;aptamer;Architecture;Bacterial DNA;Biology;Biophysics;Biotinylation;Cell Nucleus;Cells;Chemicals;Chemistry;Chromatin Loop;Collection;Cultured Cells;design;DNA;DNA-Binding Proteins;DNA-Directed RNA Polymerase;Elements;Environment;Escherichia coli;Exclusion;Exhibits;experimental study;Gene Expression Regulation;Genes;Heterodimerization;Home;Homing;In Vitro;in vivo;innovation;interest;Investments;kinked DNA;Laboratories;Lac Operon;Learning;Ligase;Modeling;Molecular Biology;multidisciplinary;Mus;novel;novel therapeutics;Nuclear;nucleic acid structure;Nucleic Acids;Peroxidases;Pharmaceutical Preparations;Polymerase Gene;Productivity;programs;promoter;Proteins;Proteomics;Research;Rewards;RNA;Sequence-Specific DNA Binding Protein;student training;Superhelical DNA;synergism;synthetic biology;Synthetic Genes;System;Tissues;tool;Training;Transcription Coactivator;Work

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


PHR: PROJECT NARRATIVE (Project 5: Maier, Neilson, Babst-Kostecka, Rasmussen) Mining pollution has overwhelmed remediation efforts in many rural and urban areas in the US and beyond. This calls for new eco-friendly and low-cost solutions to mitigate the impact of this hazardous waste on human health in communities neighboring mining waste. The proposed research will optimize remediation technology to generate lasting vegetation covers that can stabilize mining wastes and prevent transport of associated contaminants via wind or ground water into surrounding areas.

PROJECT_TERMS: Address;Affect;Air;Amendment;anthropogenesis;Area;Atriplex;Burial;Cessation of life;Communities;cost;cost effective;Deposition;Development;Dust;Environment;Environmental Health;Environmental Impact;Environmental Wind;Expenditure;Experimental Designs;exposed human population;Exposure to;follow-up;Friends;Genomics;Germination;Goals;ground water;Growth;Guidelines;Habitats;Hazardous Waste;Health;health assessment;Human;Immobilization;improved;indexing;Industrial Waste;Industrialization;Industry;innovation;International;Intervention;intervention cost;Knowledge;Link;Location;Metals;Methods;microbial;Mining;Monitor;Natural Source;Outcome;Particle Size;Performance;Phenotype;plant growth/development;Plant Roots;Plants;pollutant;Pollution;Population;premature;prevent;Process;Property;prospective;remediation;Research;Research Personnel;response;restoration;Risk;rural area;Seedling;Series;Site;Societies;Soil;Southwestern United States;superfund site;System;system architecture;Systems Development;Tail;Technology;technology validation;Testing;Thick;Toxicant exposure;Trace Elements;trait;urban area;wasting;Water;Water Pollution

PROJECT_TITLE: Importance of Capping Material Properties in Remediation of Mine Tailings


ADMINISTERING_IC: VA

FUNDING_MECHANISM: OTHERS

IC_NAME: Veterans Affairs

ORG_NAME: MICHAEL E DEBAKEY VA MEDICAL CENTER

PHR: The proposed CDA seeks to address food insecurity among post-9/11 Veterans with focus on underlying contributors (e.g., financial instability, health conditions, and isolation). Using human-centered design, key stakeholders (e.g., Veterans, community partners, VHA social work and VBA outreach specialists) and I will design and pilot an intervention to provide food insecure Veterans with peer support and help them navigate existing services that address underlying contributors to food insecurity. I will also examine community-based screening practices for food insecurity and other health-related social needs in Veterans. CDA training objectives focus on participatory methods, experimental design, implementation science, and grant writing. In Year 3, I will submit an IIR proposal to conduct a hybrid type 1 study of the intervention. As a VA-based nurse scientist, I will use the skills, mentorship, and experience gained from my CDA to generate research that will inform practice and policy to address complex social needs affecting Veterans.

PI_NAMEs: KAMDAR, NIPA P (contact)

PROJECT_TERMS: acceptability and feasibility;Address;Affect;Applications Grants;arm;Award;Awareness;career;Characteristics;cohort;Communities;community engaged approach;community organizations;community partners;Community Services;community setting;Complex;Consumption;cost;Data;depressive symptoms;design;Diabetes Mellitus;Diet;Economic Conditions;Economics;Enrollment;Evaluation;experience;Experimental Designs;Exposure to;feasibility trial;Feeling suicidal;Fellowship;Food;Food Access;food insecurity;food security;Goals;Grant;Health;health care availability;health care settings;Homogeneously Staining Region;Household;human centered design;Hunger;hybrid type 1 study;implementation science;improved;Individual;innovation;Intervention;Intervention Studies;Intervention Trial;Interview;Knowledge;Maps;Mental Depression;Mental Health;Mentorship;Methodology;Methods;Nurse Practitioners;Nurses;nutrition;Nutritional;Obesity;outreach;peer support;Personal Satisfaction;Policies;post 9/11;post intervention;prevent;Process;programs;recruit;Research;Research Methodology;Research Personnel;Research Support;Resources;Risk;rurality;Scientist;screening;service organization;Services;skills;social;social health determinants;Social isolation;Social Work;socioeconomics;Specialist;Surveys;Texas;therapy design;Time;Training;Translating;Trust;Unemployment;United States Department of Veterans Affairs;Veterans;Woman;Writing

PROJECT_TITLE: Designing veteran-centered strategies to reduce and prevent food insecurity: A veteran and community-partnered approach

STUDY_SECTION_NAME: Research Career Scientist[MRA0]


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

ORG_DEPT: DENTISTRY

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: PROJECT NARRATIVE The goal is to understand the mechanisms by which nuclear-encoded RNA binding pentatricopeptide repeat (PPR, 35 amino acids) proteins orchestrate mitochondrial mRNA biogenesis and translation in Trypanosoma brucei. Because PPR-mediated elements of these processes are unique to a parasite responsible for devastating diseases, the proposed studies will expand the fundamental knowledge of essential molecular mechanisms in a medically and economically significant pathogen.

PI_NAMEs: AFASIZHEVA, INNA  (contact)

PROGRAM_OFFICER_NAME: JOY, DEIRDRE A

PROJECT_TERMS: 5' Untranslated Regions;adenylate;Affinity;African;Amino Acids;Animals;Antigenic Variation;Architecture;Area;Binding;Binding Sites;Biogenesis;Biology;Biotinylation;Chemicals;Complex;Consensus Sequence;Conserved Sequence;crosslink;Cryoelectron Microscopy;Custom;Dedications;Diphosphates;Disease;Economic Burden;Elements;endonuclease;Ensure;Enzymes;Event;Exposure to;Family;Funding;gene discovery;Gene Expression;Genetic;Genetic Materials;Genetic Transcription;Goals;Guide RNA;health economics;Health Hazards;Helix-Turn-Helix Motifs;high reward;high risk;Human;Hydrolysis;In Vitro;in vivo;Individual;innovation;insertion/deletion mutation;knock-down;Knowledge;Laboratories;marginalized population;Mass Spectrum Analysis;Mastigophora;Mediating;Medical;Messenger RNA;Mitochondria;mitochondrial messenger RNA;Mitochondrial RNA;Modality;Modeling;Modification;Molecular;Monitor;mRNA Precursor;mRNA Stability;mRNA Surveillance;mRNA Transcript Degradation;mRNA Translation;Mutate;Mutation;new therapeutic target;novel;Nuclear;Organelles;Organism;Outcome;Parasites;Parasitic infection;pathogen;Phosphorylation;Plants;Poly(A)-Binding Proteins;Polymerase;polypeptide;Positioning Attribute;Post-Transcriptional Regulation;Pre-mRNA Polyadenylation Factor;prevent;Process;programs;promoter;Property;Protein Biosynthesis;Protein Engineering;Proteins;Protozoa;Public Health;Reaction;Reader;Reading;reconstitution;recruit;Resolution;Resources;ribosome profiling;Ribosomes;RNA;RNA Binding;RNA Degradation;RNA Sequences;RNA-Binding Proteins;Role;Science;sensor;Site;Specificity;Structure;Substrate Specificity;Tail;Testing;Therapeutic;Transcript;Transcription Initiation;Translational Activation;translational potential;Translations;Trypanosoma;Trypanosoma brucei brucei;Trypanosomiasis;uridylate;Vaccines;Validation;vector control;X-Ray Crystallography

PROJECT_TITLE: REPEAT-CONTAINING RNA BINDING PROTEINS OF TRYPANOSOMES

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDM-M(02)M]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Genetics

ORG_CITY: LA JOLLA

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

PHR: PROJECT NARRATIVE Integrated quality control (QC) systems are required to sense and manage mitochondrial stress, and their dysregulation is associated with a number of diseases including neurodegenerative disease, aging, and cancer. The human ATP-dependent AAA+ protease, LONP1, has emerged as a master regulator of diverse mitochondrial functions, is an integral component of mitochondrial QC systems, and alterations in its activity are implicated in mitochondrial diseases, aging, and cancer. This proposal will provide structural and mechanistic models describing the allosteric regulation and control of LONP1's proteolytic activity and determine the molecular mechanism and conformational state required for LONP1's single-stranded mtDNA binding activity.

PI_NAMEs: MINDREBO, JEFFREY TODD (contact)

PROGRAM_OFFICER_NAME: TAYLOR, VERONICA

PROJECT_TERMS: Adopted;Affect;Aging;Allosteric Regulation;ATPase Domain;Automobile Driving;Binding;Biochemical;Biological Assay;Biology;biophysical analysis;Biophysics;C-terminal;Cell Physiology;Cerebrum;Clinical;Complex;Cryoelectron Microscopy;cytochrome c oxidase;Dental;Development;developmental disease;Disease;Disparate;DNA Binding;DNA-Binding Proteins;Embryo;endopeptidase La;factor A;Genetic Transcription;Genome;Genome Stability;genomic locus;Goals;Hand;Health;Homeostasis;Human;Hypoxia;insight;Knock-out;Length;Maintenance;Malignant Neoplasms;Maps;Mediating;Metabolism;Methodology;mimetics;Mitochondria;Mitochondrial Diseases;Mitochondrial DNA;mitochondrial genome;Modeling;Molecular;Molecular Chaperones;Molecular Conformation;Morphology;Mus;Mutation;N-terminal;Neurodegenerative Disorders;Nucleotides;oxidative damage;Oxidative Phosphorylation;Oxidative Stress;Pathogenesis;Peptide Hydrolases;Post-Translational Protein Processing;Process;professor;Protease Domain;protein aggregation;Proteins;proteostasis;Protomer;Publishing;Quality Control;Regulation;Regulation of Proteolysis;Reporting;Respiration;response;Role;skeletal;Small Interfering RNA;SS DNA BP;steroidogenic acute regulatory protein;Stress;Structure;Supervision;Syndrome;System;Training;transcription factor;Transcriptional Regulation;Translations;Untranslated RNA;Work

PROJECT_TITLE: Defining Structural and Molecular Mechanisms of The Human Multifunctional Mitochondrial Protease, LONP1


NIH_SPENDING_CATS: Behavioral and Social Science;Biomedical Imaging;Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Genetic Testing;Genetics;Health Services;Human Genome;Patient Safety;Prevention;Women's Health Research

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE A single approach to genetic counseling may not fit the needs for all patients, and genetic counseling models that increase access to genetic testing and are more patient-centered may better serve patients. The proposed study will test a novel genetic counseling patient preference (GCPP) intervention integrated within an electronic health record (EHR) patient portal compared to conventional genetic counseling for women at elevated breast cancer risk. Study results will provide the efficacy for using a novel cancer genetic counseling approach via EHR patient portal that will be readily adaptable to other health care systems in the future, inform best practices, and reduce workforce burden.

PI_NAMEs: KATZ, MIRA L;SWEET, KEVIN M. (contact)

PROGRAM_OFFICER_NAME: SHELBURNE, NONNIEKAYE F

PROJECT_TERMS: Address;Adherence;Agreement;Assessment tool;Breast Cancer Genetics;Breast Cancer Risk Factor;Breast Magnetic Resonance Imaging;cancer genetics;Cancer-Predisposing Gene;Clinical;clinical care;clinical encounter;colorectal cancer screening;comparison intervention;Counseling;Distress;Education;efficacy evaluation;Electronic Health Record;experience;Family;Future;Genes;Genetic Counseling;genetic testing;Goals;group counseling;Guidelines;Healthcare Systems;Heredity;High-Risk Cancer;improved;Individual;innovation;Intervention;Knowledge;Malignant Breast Neoplasm;Malignant Neoplasms;Mammographic screening;Mammography;Medical;Methods;Modeling;Mutation;National Comprehensive Cancer Network;novel;Online Systems;Participant;patient health information;patient oriented;patient portal;Patient Preferences;Patients;Perception;Persons;polygenic risk score;preference;Prevention strategy;Process;Public Health;Randomized;Randomized, Controlled Trials;Recommendation;Recording of previous events;Reporting;Research;Risk;Risk Assessment;risk perception;satisfaction;screening;Screening for cancer;screening guidelines;Self Direction;service delivery;Telephone;telephone coaching;Test Result;Testing;Time;Triage;United States;web-based tool;Woman;women's outcomes;Work

PROJECT_TITLE: A Randomized Controlled Trial: Genetic Counseling Patient Preference Intervention via Electronic Health Record Portal vs. Conventional Genetic Counseling for Women at Elevated Risk for Breast Cancer


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Clinical Research;Kidney Disease;Pediatric;Prevention

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

PHR: PROJECT NARRATIVE Chronic kidney disease is a leading cause of death in Central America, largely affecting young, working age men, and the causes of this disease are unknown. In this study, we will follow a cohort of children, adolescents and young adults for three years to evaluate the association between exposures to heavy metals, chemicals and heat and kidney function and develop a predictive biomarker of reduced kidney function. The goal of this study is to identify early-life risk factors for this devastating disease, with the ultimate aim of preventing future CKD in the region.

PI_NAMEs: LEIBLER, JESSICA H (contact)

PROGRAM_OFFICER_NAME: JOUBERT, BONNIE

PROJECT_TERMS: Acute;Address;Adolescence;Adolescent;Adolescent and Young Adult;Adult;Affect;Age;Age Years;Agricultural Workers;Agriculture;Agrochemicals;Aromatic Polycyclic Hydrocarbons;Biological Markers;Boston;candidate marker;case control;Cause of Death;Central America;Cessation of life;Characteristics;Chemical Exposure;Chemicals;Child;Chronic;Chronic Kidney Failure;cohort;Communicable Diseases;Country;Creatinine;Data;Dehydration;design;Diagnosis;Diet;Disease;Early Diagnosis;Early identification;early onset;Egypt;Endocrine Disruptors;Enrollment;Environmental and Occupational Exposure;Environmental Exposure;Epidemic;Epidemiology;Etiology;experience;Exposure to;follow-up;Foundations;Funding;Future;Goals;Health;Heat Stress;Heavy Metals;high risk;Humidity;Incidence;Income;India;Individual;Industry;Injury to Kidney;innovation;International;Kidney;Kidney Diseases;Knowledge;Life;Longitudinal cohort;longitudinal design;Low Prevalence;male;Medical;men;Mesoamerican;Metals;Methodology;Methods;Monitor;mortality;nephrotoxicity;Nicaragua;novel;Occupational;Occupational Exposure;Occupations;Onset of illness;Outcome;Outcome Assessment;Pathology;Patients;Pesticides;Pharmaceutical Preparations;Population;predictive marker;Predisposition;prevent;Prevention;Proteins;Proteome;Proteomics;Public Health;Publishing;Recording of previous events;recruit;Renal function;Research;Risk Factors;Risk Reduction;Saccharum;Sampling;Serum;Silicones;Sri Lanka;Statistical Methods;Techniques;Temperature;Time;United States National Institutes of Health;Universities;urinary;volatile organic compound;Work;working men;wristband;young adult;young man;Youth

PROJECT_TITLE: The NINOS cohort: Children's Kidney Health in a High-Risk Region for CKDu

STUDY_SECTION: KNOD

STUDY_SECTION_NAME: Kidney, Nutrition, Obesity and Diabetes Study Section[KNOD]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Pediatric;Prevention;Primary Health Care;Sleep Research;Social Determinants of Health

PHR: Sleep is critical for supporting mental health and academic and social performance during adolescence, yet most teens have unhealthy sleeping patterns that put them at increased risk for poor psychiatric health across the lifespan. The proposed project evaluates SHEETS (Sustainable Habits for Encouraging Even Teen Sleep), a digital sleep health intervention delivered in primary care, as a tool to help adolescents develop steady sleep schedules and enhance behavioral health. By improving consistency in sleep schedules for adolescents through a scalable digital format, SHEETS may support psychiatric wellness now and in the future for adolescents living in diverse communities.

PI_NAMEs: DUKE, NAOMI N;LUNSFORD-AVERY, JESSICA RUTH (contact)

PROGRAM_OFFICER_NAME: ROONEY, MARY

PROJECT_TERMS: acceptability and feasibility;actigraphy;active control;active control group;Adherence;Adolescence;Adolescent;Aftercare;Age;Arousal;Attention;Beds;Behavioral;behavioral health;behavioral health intervention;behavioral sleep intervention;Caring;Child health care;Clinical Trials;Communities;comparison control;conduct problem;Control Groups;critical developmental period;critical period;Development;Diagnostic;diagnostic biomarker;digital;digital health;digital intervention;digital platform;Disease;Education;Effectiveness;effectiveness evaluation;Emotional;Exhibits;Feedback;follow-up;Foundations;functional outcomes;Future;Goals;Habits;Health;Health behavior change;Health Services;improved;improvement on sleep;innovation;Intervention;Intervention Studies;Interview;Life Cycle Stages;life span;Link;Measures;Mediating;Mediator;Medicine;Mental Depression;Mental disorders;Mental Health;Modeling;Monitor;Motivation;Outcome;Parents;patient retention;Pattern;Performance;Persons;poor sleep;Population Heterogeneity;Positioning Attribute;post intervention;practice setting;Preparation;Prevention;Preventive care;preventive intervention;Primary Care;primary care practice;primary care setting;Process;Psychiatry;Psychoses;psychosocial;Randomized, Controlled Trials;recruit;Reporting;Research;Research Domain Criteria;Risk;Risk Factors;satisfaction;Schedule;Science;sensor;severe mental illness;Sleep;sleep behavior;Sleep disturbances;sleep health;sleep pattern;social;social culture;Social Environment;Social Work;Sociology;Symptoms;System;tailored messaging;Teenagers;therapy development;Time;tool;Translations;trial design;uptake;wearable device;Work;Youth

PROJECT_TITLE: Sustainable Habits for Encouraging Even Teen Sleep (SHEETS): A Digital Intervention to Enhance Sleep Regularity and Psychiatric Health in Adolescents


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Genetics;Human Genome;Infectious Diseases;Lung;Prevention;Rare Diseases;Tuberculosis

ORG_DEPT: GENETICS

PHR: Project Narrative This project will investigate how genetic pathways identified in humans influence the central structure of tuberculosis, the mycobacterial granuloma. We will investigate how host genetic variation determines the architecture and dynamics of the granuloma, and test functionally how infecting Mycobacterium tuberculosis responds within the constraints of this structure to survive and replicate. Understanding granuloma biology more fully may provide new therapeutic opportunities to combat tuberculosis.

PI_NAMEs: TOBIN, DAVID M. (contact)

PROGRAM_OFFICER_NAME: LACOURCIERE, KAREN A

PROJECT_TERMS: Animal Model;Architecture;Bacteria;Bacterial Genes;Biology;C3HeB/FeJ Mouse;Cavia;cell type;Cells;Characteristics;combat;Complex;Confocal Microscopy;Culture Techniques;Data;Disease;Disease Outcome;Disease Progression;Dose;Environment;Equilibrium;experimental study;Exposure to;Gene Expression Profiling;Genes;Genetic;genetic association;genetic manipulation;Genetic Predisposition to Disease;Genetic study;Genetic Transcription;genetic variant;Genetic Variation;genome wide association study;genome-wide;genomic locus;Genotype;Genus Mycobacterium;Granuloma;Growth;Histopathology;Human;Human Genetics;Image;imaging approach;Immune;Immune response;Immunity;in vivo;Infection;Intervention;latent infection;Lead;Lesion;Libraries;Link;Macrophage;Modeling;Mouse Strains;Mus;mutant;mycobacterial;Mycobacterium marinum;Mycobacterium tuberculosis;Necrosis;nonhuman primate;novel;novel therapeutics;Oryctolagus cuniculus;Outcome;pathogen;Pathogenicity;Pathway interactions;Persons;Pharmaceutical Preparations;pharmacologic;Physiological;Predisposition;Process;programs;Property;Pulmonary Tuberculosis;Regulation;Role;Shapes;Specimen;Structure;Susceptibility Gene;System;Testing;Therapeutic Intervention;Translating;transmission process;transposon sequencing;Tuberculosis;tuberculosis granuloma;whole genome;Zebrafish

PROJECT_TITLE: Linking Human TB Genetic Susceptibility Loci to Granuloma Biology


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Prevention;Sleep Research

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: Alzheimer's disease (AD) is one of the largest public health challenges worldwide. The proposed work will identify the timing of changes in neuronal activity in cortical parvalbumin-containing interneurons using the AD mouse models and determine the effect on sleep, AD pathology, and memory. This work will inform early novel intervention strategies to prevent or delay AD progression.

PI_NAMEs: KATSUKI, FUMI  (contact)

PROGRAM_OFFICER_NAME: HAAKENSON, CHELSEA MARIE

PROJECT_TERMS: abeta accumulation;abeta deposition;Age;age related biomarkers;Age-associated memory impairment;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer’s disease biomarker;Amyloid beta-Protein;amyloid pathology;Animals;APP-PS1;Area;Award;Behavior;Biological Assay;Biological Markers;Boston;Brain;cell cortex;cell type;Characteristics;Clinical;Cognition;conditioned fear;Coupling;Data;Dementia;density;Development;Disease;Disease Progression;Early identification;Early Intervention;Educational workshop;experimental study;Faculty;Family;Fiber;Foundations;Functional disorder;Generations;Genetic;genetic manipulation;Genetic Models;Goals;hippocampal pyramidal neuron;Hippocampus;Human;Impaired cognition;In Vitro;in vivo;Interneurons;Intervention;Learning;Link;Literature;Long-Term Effects;longitudinal design;Massachusetts;Medial;medical schools;Memory;Memory impairment;Mentorship;Methods;mouse genetics;mouse model;Mus;Myoepithelial cell;network dysfunction;neural;Neuroanatomy;neuronal excitability;Neurons;non rapid eye movement;novel;Parvalbumins;Pathogenesis;Pathology;Patients;Photometry;Play;Polysomnography;Populations at Risk;pre-clinical;Prefrontal Cortex;prevent;Public Health;Reporting;Research;Research Personnel;Role;signal processing;skills;Sleep;sleep abnormalities;Sleep disturbances;sleep spindle;Solid;Symptoms;Techniques;Testing;Therapeutic;Training;Universities;Work

PROJECT_TITLE: Alteration of sleep and cortical parvalbumin interneurons in mouse model of Alzheimers disease

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Basic Neuroscience of Aging Study Section[NIA-N]


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Networking and Information Technology R&D (NITRD);Social Determinants of Health

ORG_CITY: MINNEAPOLIS

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF MINNESOTA

PHR: Narrative This project will develop data for prospective analysis of the impact of early-life circumstances and environment on health outcomes in late life, including Alzheimer’s disease. The creation of the proposed database is urgent and will provide a resource of unprecedented power for understanding the effects of public policies, social institutions, and environmental conditions on the health, well-being, and functioning of people, both over the life course and in their later years. The proposed work is directly relevant to the core mission of the Population and Social Processes branch of NIA, since the data will allow us to observe today’s late-life population when they were young.

PI_NAMEs: FITCH, CATHERINE A;RUGGLES, STEVE  (contact);WARREN, JOHN ROBERT

PROGRAM_OFFICER_NAME: NGUYEN, EMERALD THAI HAN

PROJECT_TERMS: Address;Adult;Affect;Aging;Alzheimer's Disease;American;Behavioral;Behavioral Sciences;Biological;blind;Books;Cause of Death;Censuses;Cessation of life;Characteristics;Childhood;Classification;Collaborations;Communities;computerized data processing;cost;cost effective;Data;data access system;data cleaning;Data Files;Data Linkages;data quality;data resource;Data Set;Data Sources;Databases;Demography;Development;Discipline;Doctor of Philosophy;Documentation;economic behavior;Economics;Education;Elements;Employment;Environment;Environmental Exposure;experience;Family;family structure;Fertility;functional status;Funding;Genetic Transcription;Geography;Goals;Health;Health and Retirement Study;health disparity;Health Surveys;Household;Human Activities;Image;Impaired cognition;Income;indexing;Individual;Infrastructure;Institution;Investments;Journals;large scale data;late life;Life;Life Cycle Stages;Link;Longitudinal Studies;Machine Learning;Manuscripts;Marketing;Medicare;Metadata;Methods;Microfilm;migration;Mission;mortality;National Archive;Neighborhoods;Outcome;Paper;Pattern;Personal Satisfaction;Persons;Population;population based;Population Process;Population Research;preservation;Private Sector;prospective;Public Policy;public-private partnership;Publications;Publishing;Records;Research;Research Personnel;Research Project Grants;Resource Sharing;Resources;response;Running;Science;Series;skills;social;social factors;Social Processes;Social Sciences;Socioeconomic Status;Sociology;Source;Street Address;Talents;Technology;Time;United States;United States National Institutes of Health;Work

PROJECT_TITLE: Prospective Microdata for Research on Aging

STUDY_SECTION: SSPB

STUDY_SECTION_NAME: Social Sciences and Population Studies B Study Section[SSPB]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Genetics;Human Genome;Mental Health;Neurosciences;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: SANTA CRUZ

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF CALIFORNIA SANTA CRUZ

PHR: Understanding the molecular and cellular defects that underlie complex diseases like autism and schizophrenia are a valuable first step towards developing approaches to prevent or ameliorate their associated pathological phenotypes. Genomic copy number variation of a segment of human chromosome 1 (1q21.1 distal deletion/duplication interval) has been associated with multiple neurodevelopmental disorders including autism and schizophrenia in multiple studies but, since this region is derived from recent segmental duplication events, it has been difficult to dissect the role the many human-specific genes in this genomic locus play in normal development and disease. Here we use new genome sequencing technologies and human pluripotent stem cell-derived cerebral cortex tissue organoids to characterize human variation at this locus and the functional role of these variants in human brain development.

PI_NAMEs: SALAMA, SOFIE REDA (contact)

PROGRAM_OFFICER_NAME: PANCHISION, DAVID M

PROJECT_TERMS: 1q21;Affect;Alleles;autism spectrum disorder;Automobile Driving;Biological;Biological Assay;Brain;brain size;Cell Culture Techniques;Cell Line;Cell Maintenance;Cell Proliferation;Cerebral cortex;Cerebrum;Chromosome 1;Chromosomes;Clustered Regularly Interspaced Short Palindromic Repeats;cognitive function;Collection;Complex;Copy Number Polymorphism;cost effective;Defect;Development;Disease;Distal;DNA;DNA Resequencing;DNA Sequence Rearrangement;Engineering;Equilibrium;Event;Evolution;experimental study;Family;Gene Conversion;Gene Dosage;Gene Duplication;Gene Expression;Gene Family;Generations;Genes;Genome;genome sequencing;genome wide association study;Genomic DNA;genomic locus;Genomic Segment;Genomics;Heterozygote;Histology;Human;Human Cell Line;Human Chromosomes;human embryonic stem cell;human embryonic stem cell line;human pluripotent stem cell;improved;Individual;innovation;Link;Location;Measurement;Measures;Methods;Modeling;Molecular;Molecular Weight;mutant;Mutation;nerve stem cell;Nervous System Disorder;neural;Neurodevelopmental Disorder;Neurologic;Neurons;novel;Organoids;Pan Genus;Pathogenicity;Pathologic;Patients;Phenotype;Play;Pluripotent Stem Cells;Population;Predisposition;premature;prevent;Proliferating;Recurrence;Reporter;Role;Sampling;Schizophrenia;segregation;Sequence Analysis;Signal Transduction;single-cell RNA sequencing;stem;stem cell proliferation;Technology;Testing;Tissues;Variant

PROJECT_TITLE: Dissecting the role of NOTCH2NL genes in human brain development and neurological disorders associated with chromosome 1q21.1 distal duplications and deletions.


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Health Services;Neurodegenerative

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE Older adults with mild cognitive impairment and dementia (MCID) frequently receive low-value care and are particularly vulnerable to its harms (e.g., routine benzodiazepine prescriptions offer limited benefit to adults with MCID and can cause delirium or falls). To begin to reduce the problem of low-value care delivery in this vulnerable group, we must understand the extent of the national problem, identify the characteristics of patients and the delivery systems with the greatest risk exposure, and whether two currently implemented strategies (payment reform and a large education campaign) were associated with less delivery of low-value care among older adults with MCID. This proposal seeks to build a foundation of evidence to inform future U.S. health policies that can reduce low-value care and improve patient-oriented outcomes in older Americans with MCID.

PI_NAMEs: MAFI, JOHN  (contact)

PROGRAM_OFFICER_NAME: KIM, THERESA YOUNGJOO

PROJECT_TERMS: accountable care organization;Adult;Age;Aging;aging related;American;Area;Benzodiazepines;care delivery;care seeking;Caring;Caucasians;Characteristics;Clinical;Cognitive;Communities;Continuity of Patient Care;Control Groups;cost;Cross-Sectional Studies;Data;Delirium;Dementia;Drug Prescriptions;Economics;Education;Ethnic Origin;Etiology;experience;Exposure to;falls;Family;Foundations;functional status;Future;Guidelines;Health;Health and Retirement Study;health equity;Health Policy;Health Status;Health system;Hospitalization;improved;Institution;Institutionalization;Interruption;Link;Literature;Longitudinal Studies;Measures;Medicare;Medicare claim;Methods;mild cognitive impairment;Morbidity - disease rate;older adult;Outcome;Patient Care;Patient-Focused Outcomes;Patients;payment;Physicians;pilot test;Policies;Policy Maker;poor health outcome;Population;Procedures;programs;Provider;Race;Research;Risk;Savings;screening;Series;Services;sex;Specific qualifier value;Subgroup;System;Testing;Time;trend;Vulnerable Populations;Work

PROJECT_TITLE: Identifying Approaches to Measure and Reduce Harmful, Low-Value Care Among Older Americans with Mild Cognitive Impairment and Dementia

STUDY_SECTION: HSOD

STUDY_SECTION_NAME: Health Services Organization and Delivery Study Section[HSOD]