NIH_SPENDING_CATS: Aging;Biodefense and Related Countermeasures;Biotechnology;Hematology;Immunization;Immunotherapy;Lymphatic Research;Physical Injury - Accidents and Adverse Effects;Prevention;Regenerative Medicine;Vaccine Related

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: Narrative Exposure to high doses of ionizing radiation within a relatively short period of time can cause acute radiation syndrome (ARS), a severe form of radiation injury that can occur at events such as a “dirty bomb” terrorist attack or nuclear power plant leakage. ARS survivors may develop delayed effects of radiation exposure (DEARE) and there are no therapeutic agents available to prevent or alleviate DEARE. Our proposal will define the functional immuno-radiobiology of the regenerative immune system after whole body irradiation in mice. Since the tissue targets of radiation injury are well studied, we can also correlate whether T-cell immune senescence and dysfunction of myeloid population contributes to DEARE. These studies will provide a blueprint for developing optimized immuno-conditioning regimens for immunization protocols in radiation survivors that can be extended to immunocompromised and elderly population.

PI_NAMEs: GUHA, CHANDAN  (contact)

PROGRAM_OFFICER_NAME: WINTERS, THOMAS A

PROJECT_TERMS: Acceleration;Acute;Agonist;Anemia;Animals;Antibody titer measurement;Antigen Presentation;Antigen-Presenting Cells;Antigens;atomic bomb;Autophagocytosis;B-Lymphocytes;Bacteremia;Biological Assay;Bone Marrow;Bone Regeneration;CD28 gene;CD3 Antigens;CD8-Positive T-Lymphocytes;cell regeneration;Cellular Immunity;Clinical;conditioning;CSF3 gene;CXCL10 gene;CXCR3 gene;cytokine;Defect;dirty bomb;Dose;Effector Cell;Elderly;Event;exhaust;exhaustion;Exhibits;Exposure to;Extravasation;Failure;FDA approved;FLT3 ligand;Functional disorder;functional restoration;ghrelin;Granulocyte-Macrophage Colony-Stimulating Factor;Helper-Inducer T-Lymphocyte;Hematopoietic Cell Growth Factors;Homeostasis;IL17 gene;IL7 gene;Immune;Immune system;Immune System Diseases;Immunization;Immunobiology;Immunocompromised Host;Immunoglobulin G;Immunoglobulin M;Immunologics;Immunology procedure;Immunophenotyping;immunosenescence;Impairment;Inflammation;Inflammatory;inhibition of autophagy;Injury;Interferon Type II;Interleukin-2;Interleukin-6;intestinal epithelium;Intestines;Ionizing radiation;Japan;Lethal Dose 50;Listeria;Longitudinal Studies;Lung;lymph nodes;Lymphocyte;Lymphocyte Count;Lymphocyte Depletion;Lymphocyte Function;lymphoid organ;Lymphopenia;Marrow;Measures;Mediating;Memory;Metformin;mimetics;mitochondrial dysfunction;Mitogen-Activated Protein Kinase Inhibitor;Modeling;Molecular Chaperones;MPL gene;mucosa-associated lymphoid tissue;Multiple Organ Failure;Mus;Myelogenous;Natural regeneration;Neutropenia;neutrophil;novel;Nuclear Power Plants;Outcome;Outcome Measure;Ovalbumin;Oxygen Consumption;p38 Mitogen Activated Protein Kinase;Peptides;peripheral lymphoid organ;Peritoneal;Phagocytosis;Phase;Phenotype;Population;prevent;Production;programmed cell death protein 1;programs;Proliferating;Proteins;Protocols documentation;Radiation;radiation countermeasure;radiation effect;Radiation exposure;Radiation Injuries;radiation mitigation;radiation mitigator;Radiation Toxicity;Radio;Radiobiology;Recombinants;regenerative;Regimen;Residual state;response;RNA vaccine;Roentgen Rays;SARS-CoV-2 spike protein;senescence;senescence associated secretory phenotype;Septic Shock;Serum;Spleen;subcutaneous;Survivors;Syndrome;systemic inflammatory response;T cell receptor repertoire sequencing;T-Cell Proliferation;T-Lymphocyte;Terrorism;Therapeutic Agents;Thrombocytopenia;Thrombopoietin;Thymus Gland;Time;Tissues;TNF gene;transcriptomics;Transgenic Mice;Vaccination;Whole-Body Irradiation

PROJECT_TITLE: Regeneration of the Immune System after Radiation Exposure


ADMINISTERING_IC: DK

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Diabetes;Infectious Diseases;Nanotechnology;Prevention;Regenerative Medicine;Wound Healing and Care

ORG_CITY: Woodland Hills

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: TERASAKI INSTITUTE FOR BIOMEDICAL INNOVATION

ORG_STATE: CA

PHR: PROJECT NARRATIVE Preventing infections, vascularization, cell migration, and reintegration with surrounding tissues are vital factors in diabetic wound healing. Here, we propose to develop an extracellular matrix (ECM) mimicking porous nanofibrous microspheres (NMs) integrated with fibrillar hydrogel to co-deliver both antibacterial and angiogenic peptides to the wound site to control infections and enhance vascularization during the diabetic wound healing. The novel open porous architecture of the NMs facilitates rapid cell migration and accelerates the healing process; thus, our goal is to engineer an inexpensive, effective, and minimally invasive combinatorial treatment strategy to treat diabetic wounds.

PI_NAMEs: VITHARIKUNNIL JOHN, JOHNSON  (contact)

PROGRAM_OFFICER_NAME: LI, YAN

PROJECT_TERMS: Acceleration;Affect;Amputation;angiogenesis;Angiogenic Peptides;Anti-Bacterial Agents;Anti-Inflammatory Agents;antimicrobial;Architecture;Bacterial Infections;Biocompatible Materials;cathelicidin;cathelicidin antimicrobial peptide;Cell Migration Induction;cell motility;Cells;Cessation of life;Chemistry;Cicatrix;combinatorial;Complication;controlled release;cytotoxicity;design;Diabetic Foot Ulcer;Diabetic mouse;diabetic patient;diabetic ulcer;diabetic wound healing;Disulfides;effective therapy;efficacy evaluation;Engineering;Extracellular Matrix;Family suidae;Flow Cytometry;Gel;Gelatin;Glucose;Glycolates;Goals;Granulation Tissue;Growth Factor;healing;Histology;Human;Hybrids;Hydrogels;Immune response;improved;In Vitro;in vivo;Individual;Infection Control;Infection prevention;infection rate;Injectable;innovation;invention;Matrix Metalloproteinases;Methacrylates;methicillin resistant Staphylococcus aureus;Microbial Biofilms;Microspheres;migration;mimetics;minimally invasive;Modality;Modeling;Monitor;Mus;nanofiber;Nanofiber Scaffold;Natural regeneration;neovascularization;novel;Nutrient;Oxidation-Reduction;Oxygen;Patients;Peptides;Photochemistry;Play;Porosity;prevent;Process;Production;Proliferating;Property;Protease Inhibitor;Quality of life;response;Role;Site;Skin;Splint Device;Sterile coverings;Sterility;Stimulus;Structure;Techniques;Technology;Testing;Therapeutic;Therapeutic Agents;Tissues;treatment strategy;Type 2 diabetic;Vascular Endothelial Growth Factors;Vascularization;wound;wound closure;wound dressing;wound environment;wound healing;Wound Infection;Wound models

PROJECT_TITLE: Engineering the open porous nanofibrous microsphere integrated fibrillar hydrogel for the co-delivery of antibacterial and angiogenic agents aimed at the rapid diabetic wound repair

STUDY_SECTION: INN

STUDY_SECTION_NAME: Innovations in Nanosystems and Nanotechnology Study Section [INN]


ADMINISTERING_IC: DC

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Dental, Oral, and Craniofacial Disease;Neurosciences;Nutrition

ORG_CITY: STONY BROOK

ORG_DEPT: PHARMACOLOGY

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

ORG_STATE: NY

PHR: PROJECT NARRATIVE Perceptual learning describes a phenomenon where animals can learn to discriminate between highly overlapping sensory stimuli (for example similar tastes, sounds or smells) with practice. The neural mechanisms underlying perceptual learning remain incompletely understood. This proposal will investigate this question by recording neural activity in the gustatory cortex as mice learn to discriminate between overlapping taste mixtures. Knowledge gained from this proposal will provide new information about taste coding, sensory processing and neuroplasticity that could ultimately be used to better understand how the brain works in both health and disease.

PI_NAMEs: KOGAN, JOSHUA  (contact)

PROGRAM_OFFICER_NAME: SCHURMAN, JACLYN REBECCA

PROJECT_TERMS: Animals;Area;Auditory;Auditory system;Axon;Behavioral;behavioral outcome;Brain;Calcium;calcium indicator;Chronic;Clozapine;Code;Cognition;comparison control;Control Animal;Data Analyses;Decision Making;design;Discrimination;discrimination task;Disease;Dopamine;Electrophysiology (science);Environment;experimental study;Fiber;Genetic;Goals;Health;Image;Implant;improved;in vivo;Infusion procedures;Ingestion;insight;Knowledge;Learning;Lesion;Mediating;Mentors;Modality;Modeling;Monitor;Mus;nerve supply;neural;neuromechanism;Neuromodulator;Neuronal Plasticity;Neurons;neuropsychiatric disorder;novel;Optics;Outcome;Oxides;Oxidopamine;Pattern;Perceptual learning;Performance;Poison;Population;Process;Psychometrics;Research;response;Rodent;Role;Sensory;sensory cortex;sensory discrimination;sensory input;sensory stimulus;Shapes;Signal Transduction;Smell Perception;sound;Stimulus;Study models;Sucrose;System;Task Performances;Taste Perception;taste stimuli;Testing;Training;transmission process;two-photon;Viral Vector;Visual;Visual System;Work

PROJECT_TITLE: The role of gustatory cortex in perceptual learning of taste


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: MAYWOOD

ORG_DEPT: SURGERY

ORG_NAME: LOYOLA UNIVERSITY CHICAGO

ORG_STATE: IL

PHR: Project narrative: Sepsis is a deadly disease that kills approximately 215,000 Americans each year. This proposed investigation will use preclinical models to determine the mechanisms underlying sepsis-associated cardiomyopathy. Studies are designed to investigate how immune cells localized in the heart tissue regulate cardiac performance, and therefore having a promising potential to develop novel therapies for clinical utility in the near future.

PI_NAMEs: SUN, YUXIANG ;ZANG, QUN SOPHIA (contact)

PROGRAM_OFFICER_NAME: SINGLETON, KENTNER L

PROJECT_TERMS: Ablation;Address;Age;American;Animal Model;Attenuated;Autophagocytosis;Bone Marrow;Cardiac;Cardiac Myocytes;Cardiomyopathies;Cause of Death;cell type;Cells;Clinical;Coculture Techniques;Critical Care;Data;design;Development;Disease;effective therapy;Embryo;Endotoxemia;Foundations;Functional disorder;Future;Genetic;ghrelin;Goals;growth hormone secretagogue receptor;Heart;heart function;heart metabolism;Homeostasis;Hormones;Hunger;Immune;Immune response;Immunity;improved;In Vitro;in vivo;Infection;Infiltration;Inflammation;Inflammatory;Injury;Investigation;Knock-out;Knockout Mice;Label;Laboratories;Life;Link;loss of function;Macrophage;Mediating;Medical;Metabolic;Metabolism;metabolomics;Methods;Mitochondria;Modeling;Molecular;monocyte;mouse model;Mouse Strains;Multiple Organ Failure;Mus;Myelogenous;Myocardial;Myocarditis;Myocardium;novel;novel therapeutics;Organ;Outcome;Paracrine Communication;Pathologic;Pathology;Pathway interactions;Pattern;Performance;Phenotype;Physiological;Pneumonia;Pre-Clinical Model;programs;Proliferating;Property;receptor;receptor expression;Receptor Signaling;Regulation;Research;response;Role;Sepsis;septic;Signal Transduction;Source;systemic inflammatory response;Testing;Tissues

PROJECT_TITLE: Cardiac Macrophage Plasticity in Sepsis-induced Cardiomyopathy

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Dissemination and Implementation Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Mental Illness;Pediatric;Post-Traumatic Stress Disorder (PTSD);Prevention;Social Determinants of Health;Substance Misuse;Substance Misuse Prevention;Violence Research;Youth Violence

ORG_CITY: CHARLESTON

ORG_DEPT: PSYCHIATRY

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: The results of the proposed study will have a significant impact on public health by providing critical information regarding the clinical and cost effectiveness of the only empirically-supported treatment to date (Risk Reduction through Family Therapy; RRFT) for adolescents with co- occurring substance use problems and PTSD symptoms. If these problems are left untreated, adolescents with interpersonal violence histories are at high risk for addiction and severe mental health disorders as they enter young adulthood and across the lifespan. Demonstrating the clinical and cost effectiveness of RRFT and more closely examining the qualitative factors that would assist in its implementation broadly, as well as engaging policy makers and brokers to work toward large scale uptake of evidence-based treatment for this population among front-line clinicians, would substantially improve practice for this population.

PI_NAMEs: DANIELSON, CARLA KMETT (contact);RIGGS, PAULA DEGRAFFENREID

PROGRAM_OFFICER_NAME: LYNCH, SEAN EDWARD WINTERS

PROJECT_TERMS: addiction;Address;Adolescence;Adolescent;Adolescent Medicine Trials Network;adolescent substance use;Adult;Affect;Area;Attitude;behavioral health;Caregivers;Child Advocacy;Childhood;Clinic;Clinical;Clinical effectiveness;Clinical Trials Network;Colorado;Communities;comorbidity;cost;Cost Analysis;cost effectiveness;Cost Effectiveness Analysis;cost-effectiveness evaluation;Cues;Data;Decision Making;Discipline;Ecology;effectiveness/implementation hybrid;effectiveness/implementation trial;Emotional;Evaluation;Evidence based intervention;Evidence based treatment;experience;Family;Family psychotherapy;follow up assessment;Frequencies;Functional impairment;Funding;Goals;Grant;high risk;high-risk adolescents;hybrid type 1 design;implementation barriers;implementation determinants;implementation facilitators;improved;Individual;interest;Interpersonal Violence;Intervention;Interview;Justice;Left;life span;Link;Memory;Mental disorders;Mental Health;mental health organization;Methods;National Institute of Drug Abuse;negative affect;Negative Reinforcements;Outcome;Outpatients;Participant;physical abuse;Policy Maker;Policy Making;Population;Post-Traumatic Stress Disorders;practice setting;Prognostic Factor;protective factors;psychosocial;Public Health;Randomized;Randomized, Controlled Trials;Reaction;Recording of previous events;recruit;reduced substance use;Relapse;Reporting;Research;research clinical testing;Respondent;Risk Factors;Risk Reduction;Sampling;satisfaction;Science;Self Medication;Sexual abuse;Site;South Carolina;standard care;substance use;Substance Use Disorder;substance use treatment;Surveys;Symptoms;Teenagers;Theoretical model;Thinking;traumatic event;treatment as usual;treatment center;uptake;Violence;Work;young adult;Youth

PROJECT_TITLE: Evaluation of Clinical Effectiveness, Cost, and Implementation Factors to Optimize Scalability of Treatment for Co-Occurring SUD and PTSD Among Teens

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: American Indian or Alaska Native;Arctic;Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Lung Cancer;Nutrition;Obesity;Patient Safety;Physical Activity;Physical Rehabilitation;Prevention;Racial and Ethnic Minority Health Research;Rehabilitation;Rural Health;Social Determinants of Health

ORG_CITY: TUCSON

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: PROJECT NARRATIVE AI/AN populations experience a disproportionate burden of obesity, which contributes to inflammatory mechanisms of carcinogenesis that may add to AI/AN cancer disparities. The purpose of this study is to assess the feasibility of a prehab intervention among AI patients diagnosed with obesity-related cancer and measure inflammatory biomarkers to evaluate the preliminary impact of the trial intervention. The results of this K08 proposal will provide essential data and experience for the candidate’s development into a translational clinical trialist working on behalf of AI/AN cancer patients.

PI_NAMEs: ERDRICH, JENNIFER A (contact)

PROGRAM_OFFICER_NAME: WALLACE, TIFFANY A

PROJECT_TERMS: Activities of Daily Living;adverse outcome;Age;Alaska Native;Alaska Native population;American Indian Population;American Indians;Anti-Inflammatory Agents;Arizona;behavior change;behavior measurement;Biological Markers;biomarker selection;Blood Pressure;cancer diagnosis;cancer health disparity;Cancer Patient;cancer risk;cancer subtypes;cancer surgery;cancer survival;Cancer Survivor;carcinogenesis;Carcinogenesis Mechanism;career;CASP3 gene;Clinical Oncology;Clinical Research;clinical translation;Clinical Trials;Clinical Trials Design;Collection;Communities;community collaboration;Comprehensive Cancer Center;Data;Development;Diagnosis;Diet;diet and exercise;Dietary Intervention;Enrollment;Environment;Excision;Exercise;exercise intervention;experience;feasibility testing;Fitness Centers;Food;functional improvement;Funding;Future;General Population;Goals;Habilitation;health equity;High Prevalence;Home;Hydrocortisone;improved;Incidence;Inflammation;Inflammatory;inflammatory marker;inflammatory milieu;inflammatory modulation;Institution;Institutional Review Boards;Insulin;Insulin Receptor;Interleukin-6;Intervention;Intervention Studies;Intervention Trial;Interview;Juglans;Leptin;Life Style;Life Style Modification;lifestyle intervention;Link;Literature;Malignant Neoplasms;Measurement;Measures;Mentorship;Metabolic dysfunction;Modeling;mortality;NOS2A gene;novel;nutrition;obese patients;Obesity;Obesity associated cancer;operation;Operative Surgical Procedures;Outcome;Outcome Measure;Outcome Study;Participant;Patients;Pattern;peer;Phase;Physical activity;physical inactivity;Positioning Attribute;post intervention;Postoperative Period;Poverty;Prealbumin;Process;programs;psychologic;Public Health;Publishing;Qualitative Research;racial population;Reporting;Research;Research Personnel;Resources;Risk;Sampling;Schedule;Serum;Serum Markers;skills;smoking cessation;social health determinants;Solid Neoplasm;Structure;study population;Surgical Oncology;Surveys;Survival Rate;Testing;therapy design;Time;tissue biomarkers;Tissue Sample;Tissues;TNF gene;tool;Training;translational clinical trial;Translations;Treatment-Related Cancer;trial design;Tribal Council;tribal member;tribal Nation;Tribes;tumor;tumor microenvironment;Underrepresented Populations;United States;Universities;waist circumference;Walking;Weight;Work;Writing

PROJECT_TITLE: A Nutrition and Exercise Prehabilitation Intervention on Inflammatory Biomarkers in American Indian Cancer Patients

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Clinical Research;Contraception/Reproduction;Genetics;Neurosciences;Pediatric;Women's Health Research

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: Mutations in MKRN3 are now recognized to be the most common genetic cause of central precocious puberty. We have made significant progress in understanding how MKRN3 regulates puberty initiation, but the exact mechanisms are yet to be fully determined. The objective of this proposal is to advance our understanding of the molecular, cellular and physiologic mechanisms of action of MKRN3, which in turn can lead to the development of new tools for the management of pubertal and reproductive disorders.

PI_NAMEs: KAISER, URSULA B. (contact)

PROGRAM_OFFICER_NAME: WINER, KAREN

PROJECT_TERMS: Adult;Age;Cardiometabolic Disease;Cardiovascular system;Cell Line;Cells;Childhood;Complex;crosslink;Data;density;Development;Diabetes Mellitus;Disease;Embryo;Environmental Risk Factor;Female;Funding;Genes;Genetic;Genetic study;GNRH1 gene;Goals;Human;human induced pluripotent stem cells;hypothalamic pituitary gonadal axis;Hypothalamic structure;Immunoprecipitation;imprint;In Vitro;in vivo;infancy;Investigation;KISS1 gene;Klinefelter's Syndrome;Knowledge;Laboratories;Life;Link;loss of function mutation;male;Malignant Neoplasms;Menarche;Messenger RNA;Molecular;Morphology;mouse model;mutant;Mutation;Neonatal;neurodevelopment;Neuronal Plasticity;Neurons;Neurosecretory Systems;novel;Nutritional;Obesity;Pathway interactions;Patients;Peripheral Blood Mononuclear Cell;Physicians;Physiological;Precocious Puberty;premature;Process;protein function;Proteins;Proteomics;pubertal timing;Puberty;receptor;Regulation;Reproduction;reproductive axis;reproductive function;reproductive system disorder;Risk;Risk Factors;RNA-Binding Proteins;Role;Scientist;Synaptic plasticity;Tertiary Protein Structure;Time;tool;transcriptome;Vertebral column

PROJECT_TITLE: Deciphering the functional role of MKRN3 in puberty and reproduction

STUDY_SECTION: ICER

STUDY_SECTION_NAME: Integrative and Clinical Endocrinology and Reproduction Study Section[ICER]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Immunotherapy;Nutrition;Orphan Drug;Precision Medicine;Rare Diseases;Urologic Diseases

ORG_CITY: SAN FRANCISCO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE The antibody-drug conjugate enfortumab vedotin (EV), which targets the surface protein NECTIN4, was recently FDA approved for patients with metastatic urothelial carcinoma but the mechanisms controlling sensitivity and resistance to EV are unknown. Using patient derived xenografts (PDX), cell lines and patient biopsy samples, I propose to: 1) investigate the roles of the PPARg and TGFb pathways in regulating NECTIN4; 2) identify novel drug combinations to increase NECTIN4 expression and enhance the efficacy of NECTIN4-targeting therapeutics; and 3) determine mechanisms underlying EV resistance. Completion of this study may lead to new clinical trials to improve the effectiveness and overcome resistance to NECTIN4-targeting therapies and may have implications beyond urothelial carcinoma to inform therapeutic strategies for other NECTIN4-expressing cancers, including breast, lung and pancreatic cancer.

PI_NAMEs: CHOU, JONATHAN  (contact)

PROGRAM_OFFICER_NAME: LIM, SUSAN E

PROJECT_TERMS: Agonist;antagonist;Antibody-drug conjugates;Area;Award;Basic Cancer Research;Binding;Binding Sites;Biological;Biological Assay;Biopsy Specimen;bladder transitional cell carcinoma;Cancer Biology;cancer cell;Cancer Center;cancer drug resistance;Cancer Model;Career Choice;Cell Line;Cell surface;Cells;Cessation of life;checkpoint therapy;Chemicals;chemotherapy;chimeric antigen receptor;chimeric antigen receptor T cells;chromatin immunoprecipitation;Clinic;Clinical Data;Clinical Trials;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;Collection;Complement;Data;Diet;Diet Modification;Down-Regulation;Drug Combinations;Drug resistance;Educational workshop;Effectiveness;experience;Experimental Models;Fatty Acids;FDA approved;Foundations;Funding;Genitourinary system;Genomic approach;Genomics;Goals;hands on research;High Fat Diet;Immunohistochemistry;improved;In Vitro;in vivo;innovation;instructor;knock-down;Knock-out;Laboratories;Lead;Luciferases;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of pancreas;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Mediating;Mediator;Medicine;Membrane Proteins;Mentors;Mentorship;Methods;Microtubules;minority patient;mouse model;National Comprehensive Cancer Network;next generation sequencing;novel drug combination;overexpression;Pathway interactions;patient derived xenograft model;Patient Selection;Patients;Pharmaceutical Preparations;pharmacologic;PPAR gamma;PPARG gene;Pre-Clinical Model;professor;promoter;Radiation Oncology;Recording of previous events;Regulatory Pathway;Research;Research Personnel;Resistance;resistance mechanism;Resources;response;Role;rosiglitazone;Sampling;Signal Transduction;skills;Small Interfering RNA;Structure;Surface;T cell therapy;targeted treatment;Technology;Testing;Therapeutic;therapeutic target;Therapeutic Uses;Thiazolidinediones;Training;transcription factor;transcriptomic profiling;transcriptomics;Transforming Growth Factor beta;Transitional Cell Carcinoma;translational cancer research;translational potential;Translational Research;tumor;tumor metabolism;Urothelium;Work

PROJECT_TITLE: Defining the roles of PPARgamma and TGFbeta in regulating NECTIN4 and resistance to NECTIN4-targeting therapies


ORG_CITY: Los Angeles

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: PROJECT NARRATIVE Early identification and monitoring of endolymphatic hydrops (EH) is critical to preventing progression of this, oftentimes, debilitating auditory/vestibular disease (which is episodic in nature). Our approach will be to combine an advanced, objective tool our lab has developed (a Joint-Otoacoustic Emission Profile), which characterizes the generation of two separate intra-cochlear responses, with perceptual measurements of pitch, and computational modeling, to improve the efficacy of EH diagnosis in humans, whose cochlea cannot be accessed or manipulated for direct study. This longitudinal approach to understanding EH is a comprehensive and bold attempt to understand its clinical manifestations as well as its underlying pathophysiology, while enhancing the diagnosis and monitoring of disease progression.

PI_NAMEs: STIEPAN, SAMANTHA MARIE (contact)

PROGRAM_OFFICER_NAME: RIVERA-RENTAS, ALBERTO L

PROJECT_TERMS: absorption;Affect;Amplifiers;Apical;Auditory;Basilar Membrane;Binaural;Binding;Clinic;Clinical;clinical diagnosis;Cochlea;Cochlear Diseases;Cochlear duct;Cochlear Hearing Loss;Computer Models;Counseling;Data;Detection;Diagnosis;diagnostic biomarker;diagnostic value;Disease;Disease Progression;Ear;Ear Diseases;Early identification;Edema;Endolymph;Endolymphatic Hydrops;External auditory canal;Frequencies;Functional disorder;Generations;hearing impairment;Human;improved;indexing;Individual;Joints;Laboratories;Link;Liquid substance;Maps;Measurement;Measures;Mechanics;Membrane;Meniere's Disease;Methods;Modeling;Monitor;Morphology;Motion;Nature;otoacoustic emission;Outer Hair Cells;Pathology;Patients;Phase;phenomenological models;Physiological;predictive modeling;prevent;Process;Production;response;Sensorineural Hearing Loss;Sensory;Site;sound;Stimulus;Symptoms;Testing;theories;timeline;tool;Transducers;transmission process;Travel;Vestibular Diseases;Work

PROJECT_TITLE: Using a Joint-Otoacoustic Emission Profile to Detect and Monitor Endolymphatic Hydrops in Humans and to Explore Mechanisms of Pathology

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Data Science;Mental Health;Neurosciences;Pediatric;Prevention;Sleep Research;Substance Misuse;Underage Drinking

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative Problematic use of alcohol, marijuana and tobacco represent enormous public health costs, and use of substances, particularly alcohol, often begins in adolescence. The big data approach proposed in this application will lead to identification of neural factors linked to risk precursors for early initiation of alcohol and other substance use, including sleep problems, internalizing behaviors, externalizing behaviors, and cognitive impairment in late childhood and early adolescence. The results generated from this project will inform the rationale for designing early detection and intervention before onset of alcohol/substance use in adolescents.

PI_NAMEs: POTENZA, MARC N (contact);ZHAO, YIHONG

PROGRAM_OFFICER_NAME: EGLI, MARK

PROJECT_TERMS: addiction;Address;Adolescence;Adolescent;adolescent alcohol and drug use;advanced analytics;Age;Alcohol abuse;Alcohol consumption;alcohol use initiation;Alcohols;Anatomy;Area;Behavior;Behavioral;Big Data;boys;Brain;brain circuitry;Brain region;Brain Stem;Characteristics;Child;Childhood;Cognitive;cognitive development;cognitive function;cognitive performance;connectome;Data;Data Science;design;Development;early adolescence;early alcohol use;Early Diagnosis;Early Intervention;executive function;Exhibits;externalizing behavior;Female;follow-up;Future;Gender;girls;gray matter;Growth and Development function;Health Care Costs;Impaired cognition;Individual;innovation;insight;Intervention;joint loading;Joints;Knowledge;Link;Literature;Longitudinal Studies;Machine Learning;male;Marijuana;Measures;Methodology;Methods;Modeling;neural;neurobiological mechanism;Neurobiology;neuromechanism;Neurosciences;novel;Pattern;Phenotype;Prefrontal Cortex;prevent;Problem behavior;prospective;Psychiatry;Public Health;Reporting;Research Design;Rest;Risk;Risk Behaviors;Role;Running;Sleep;Sleep Disorders;Sleep disturbances;structural imaging;substance use;Substance Use Disorder;Surface;Testing;Thalamic structure;Time;Tobacco;Trees;underage drinking;United States National Institutes of Health;young adult

PROJECT_TITLE: Cortical subcortical reorganization and risk behaviors of early alcohol use initiation

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Cancer Genomics;Estrogen;Genetics;Human Genome;Prevention;Women's Health Research

ORG_CITY: BIRMINGHAM

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Loss of NF1 plays a major role as an oncogenic driver in many cancer types and can be found in up to 33% of all breast cancers (BC); it is a prognostic indicator for increased cancer risk at an earlier age, poorer outcomes, and therapeutic resistance. We have generated novel rat models deficient for Nf1 including a pathogenic patient missense allele (p.R1276Q knockin or KI) as well as a 14 base pair deletion (p.P1220fs*1223 knockout or KO) allele that have a very robust ER+ BC phenotype with apparent lung metastases. Our overall goal is to characterize the phenotype of these rat models in terms of histopathology, Ras signaling, hormone signaling, immune components, and targeted drug response and compare/contrast them with what is known regarding patients with somatic or germline inactivation of NF1 and breast cancer.

PI_NAMEs: KESTERSON, ROBERT A;WALLIS-SCHULTZ, DEEANN  (contact)

PROGRAM_OFFICER_NAME: NADEAU, CHRISTINE FRANCES

PROJECT_TERMS: Acceleration;Address;Advanced Development;Affect;Age;Alleles;antagonist;Base Pairing;Binding;biobank;Breast Cancer Patient;cancer biomarkers;cancer risk;cancer type;Cell Line;Cell Proliferation;cell type;Cells;Clinical;Data;Data Set;Databases;Development;differential expression;Disease;Drug Targeting;Estrogen Antagonists;Estrogen Receptors;Estrogens;Evaluation;Female;Future;genetic corepressor;Genetic Markers;Genetic Transcription;Genotype;Germ Lines;Goals;Growth;Harvest;Heterozygote;Histology;Histopathology;hormonal signals;Hormone Receptor;hormone therapy;Hormones;Human;Human Biology;Immune;Immune system;Immune Targeting;Immunotherapy;In Vitro;in vivo;inhibitor;Knock-in;Knock-out;Lead;lung lesion;Macrophage;Maintenance;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Neoplasms;Mammary Tumorigenesis;MAP Kinase Gene;MEKs;Metastatic breast cancer;Metastatic Neoplasm to the Lung;Modeling;Molecular;mouse model;mutant;Mutation;neoplastic;NF1 gene;NF1 mutation;novel;novel marker;novel therapeutics;Oncogenic;Outcome;Ovariectomy;Partner in relationship;Pathogenicity;patient derived xenograft model;Patients;Phenotype;Play;Population;pre-clinical;Pre-Clinical Model;Pregnancy;prognostic;prognostic indicator;public database;RAS driven tumor;Rattus;Receptor Signaling;Resistance;response;response biomarker;Role;Sampling;Signal Transduction;single nucleus RNA-sequencing;Spinal;Syndrome;synergism;Tamoxifen;targeted treatment;Testing;The Cancer Genome Atlas;Therapeutic;therapeutic evaluation;therapeutic target;therapy resistant;Time;Tissues;transcriptome sequencing;treatment response;tumor;Tumor Cell Line;tumor growth;tumor initiation;tumor microenvironment;Validation;Variant;Xenograft Model

PROJECT_TITLE: Loss of NF1 drives hormone dependent mammary carcinogenesis in a rat model with intact immune system


ADMINISTERING_IC: AG

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_DEPT: NEUROLOGY

PHR: PROJECT NARRATIVE The proposed grant would support the training for postdoctoral MD trainees who are planning a career in clinical research in Behavioral Neurology and neurodegenerative disease. The program is led by Drs. Howard Rosen and Bruce Miller, both experienced researchers, and provides fellows with an integrated understanding of the clinical, epidemiological, genetic, and molecular features of neurodegenerative diseases. The goal of the program is to train future academic researchers.

PI_NAMEs: MILLER, BRUCE L;ROSEN, HOWARD J (contact)

PROGRAM_OFFICER_NAME: ROVESCALLI, ALESSANDRA C

PROJECT_TERMS: Alzheimer's disease related dementia;Fellowship;Interdisciplinary Study

PROJECT_TITLE: Multidisciplinary Research Fellowship in Alzheimer's disease and Related Dementias


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Atherosclerosis;Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Heart Disease;Heart Disease - Coronary Heart Disease;Mental Health;Mental Illness;Physical Activity;Prevention;Rehabilitation;Telehealth

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Most of the 1 million Americans suffering a heart attack or related event each year are unable to increase their physical activity to recommended levels, despite the clear benefits of activity on recovery and survival. We propose a randomized controlled trial testing a novel program for this group of patients that combines a traditional physical activity program with positive psychology exercises designed to boost optimism, motivation, gratitude, and confidence. If this new program is more successful than existing clinical management in increasing activity among these high-risk patients, it could ultimately be adopted in clinical practice to improve recovery and reduce rates of death after major cardiovascular events.

PI_NAMEs: HUFFMAN, JEFF C (contact)

PROGRAM_OFFICER_NAME: CAMPO, REBECCA A

PROJECT_TERMS: Accelerometer;acute coronary syndrome;Address;Adherence;Adopted;Adverse effects;Affect;American;Anxiety;Anxiety Disorders;behavior change;Behavior Therapy;Behavioral;Biological;Biological Markers;Cardiac;Cardiac rehabilitation;cardiovascular health;Cardiovascular system;Clinical;clinical care;clinical implementation;Clinical Management;clinical practice;Death Rate;design;Event;evidence base;Exercise;Expectancy;follow up assessment;Fostering;Funding;Future;Goals;gratitude;Group Interviews;Guidelines;Health;Health behavior;health difference;high risk;hospital readmission;improved;Intervention;Light Exercise;Link;Measures;Medical;Mental Depression;Methods;moderate-to-vigorous physical activity;mortality;Motivation;motivational enhancement therapy;multi-site trial;Myocardial Infarction;National Heart, Lung, and Blood Institute;novel;optimism;Outcome;Outcome Measure;Outcome Study;Participant;Pathway interactions;patient engagement;Patient Self-Report;Patients;Personal Satisfaction;Persons;Phase;Physical activity;Physical Function;physical inactivity;Pilot Projects;Population;primary outcome;Prognosis;programs;prospective;psychologic;Psychological Factors;Psychology;Public Health;Randomized, Controlled Trials;Recommendation;Recovery;Recurrence;remote delivery;sedentary;Self Efficacy;Site;sociodemographics;standard of care;Telephone;telephone delivery;telephone session;Testing;Text;Text Messaging;theories;Time;Time Study;treatment as usual;Treatment Efficacy;Unstable angina;uptake;Visit;Well in self;Work

PROJECT_TITLE: A novel psychological-behavioral intervention to promote physical activity after acute coronary syndrome

STUDY_SECTION: SSPT

STUDY_SECTION_NAME: NHLBI Single-Site and Pilot Clinical Trials Study Section[SSPT(JA)]


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;Human Genome;Infectious Diseases;Lung;Rare Diseases;Tuberculosis

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: Closely related species of nonhuman primates (rhesus and cynomolgus macaques) exhibit different levels of susceptibility to Tuberculosis (TB), yet the underlying mechanism is unknown. This project aims to compare the primate immune genes in response to TB infection to identify species-specific immune genes (or isoforms) that influence susceptibility to TB among primates. Novel identified genes and the proteins they encode can be functionally validated and be used as drug or vaccine targets for TB.

PI_NAMEs: ROODGAR, MORTEZA  (contact)

PROGRAM_OFFICER_NAME: TANDON, RITESH

PROJECT_TERMS: acute infection;Address;Advisory Committees;Affect;African Green Monkey;Bacteria;Biological Assay;Blood Cells;candidate identification;Cause of Death;Cells;Cercopithecidae;Communicable Diseases;comparative;comparative genomics;cytokine;Data;Disease susceptibility;Drug Targeting;Ectopic Expression;Environment;Enzymes;Exhibits;experience;experimental study;Genes;Genetic Polymorphism;Genome;genome annotation;Genomic approach;Genomics;Goals;Human;human data;Immune;Immune response;Immune Response Genes;Immunogenetics;Immunogenomics;Immunologic Markers;Immunology;In Vitro;Infection;Inflammatory;Innate Immune Response;Innate Immune System;insight;Interferon Type II;lens;Macaca;Macaca fascicularis;Macaca mulatta;Macaca nemestrina;Macrophage;Measures;Medicine;member;Mentored Research Scientist Development Award;Mentors;Methods;Modeling;Molecular;Mycobacterium tuberculosis;Nitric Oxide;nonhuman primate;NOS2A gene;novel;novel strategies;Orthologous Gene;Pathogenesis;Peripheral Blood Mononuclear Cell;Persons;Pharmaceutical Preparations;Population;Predisposition;Prevention;Primates;Protein Isoforms;Proteins;Recording of previous events;Research;Resistance;Respiratory Disease;response;Risk;Role;single-cell RNA sequencing;System;Testing;Training;transcriptome sequencing;transmission process;Tuberculosis;tuberculosis immunity;tuberculosis treatment;Vaccines;Variant;vervet;whole genome

PROJECT_TITLE: Immunogenomics of susceptibility to tuberculosis (TB) among nonhuman primate species


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Pediatric

ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: Project Narrative (Public Health Relevance) Children's naturalistic environments often contain background noise—such as other talkers, televisions and computers, heating and ventilation systems, and outside traffic—that interferes with children's ability to process spoken input. Spoken input is the sole source of word learning for preschool-age children; thus, background noise may interfere with children's ability to learn words, a critical process during early childhood that is related to long-term academic and occupational success. The purpose of the proposed research is to determine how different types and intensity levels of background noise disrupt word learning, which ultimately will advance our understanding of how to maximally support word learning in real-world environments.

PI_NAMEs: GRIECO-CALUB, TINA M (contact)

PROGRAM_OFFICER_NAME: SALO, VIRGINIA CHARLOTTE

PROJECT_TERMS: 6 year old;Academic achievement;Affect;Age;Air;Attention;attentional control;Biological Factors;career;Characteristics;Child;Child Behavior;Child Development;Child Language;Childhood;Chronic;Cognitive;cognitive ability;cognitive development;cognitive process;cohort;Computers;Development;early childhood;Educational process of instructing;Employment;Ensure;Environment;Equilibrium;Exposure to;Familiarity;Foundations;Future;Goals;hearing impairment;Heating;improved;Individual Differences;Knowledge;Language;Language Delays;Language Development;Language Development Disorders;Learning;life span;Link;literacy;Literature;Location;Loudness;Methodology;National Institute of Child Health and Human Development;Noise;Normal Statistical Distribution;novel;Nursery Schools;Occupational;Outcome;Perception;Performance;Phonetics;phonology;Predisposition;Process;public health relevance;Randomized;Reader;Research;Research Priority;Risk;Scheme;School-Age Population;Semantics;Short-Term Memory;Signal Transduction;skill acquisition;skills;Source;Spatial Distribution;Speech;Speech Perception;Stream;success;System;Taxes;Television;Testing;therapy design;Time;Training;Variant;ventilation;Vocabulary;word learning;Work

PROJECT_TITLE: Effects of background noise on word learning in preschool-age children


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Biodefense and Related Countermeasures;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PHR: PROJECT NARRATIVE This research will contribute to public health efforts to improve treatment and prevention outcomes for people living with or at risk for HIV in U.S., especially those belonging to racial/ethnic minority communities. Findings from this study will have important implications for HIV treatment and prevention approaches for the COVID-19 or related future pandemic. This research has the potential to make important contributions towards addressing some of the key public health problems in the U.S., including attainment of the UNAIDS 95-95-95 targets for HIV; addressing health disparities in the U.S.; and engendering health equity in public health interventions to address racial/ethnic disparities.

PI_NAMEs: PATEL, RENA CHIMAN (contact)

PROGRAM_OFFICER_NAME: SCOTT-SHELDON, LORI ANN JENNIFER

PROJECT_TERMS: Address;Adult;Affect;American;Area;Biological Factors;Black Populations;Black race;breakthrough infection;Caring;Cessation of life;Characteristics;Clinical;cohort;Color;Communities;comorbidity;COVID-19;COVID-19 impact;COVID-19 incidence;COVID-19 pandemic;COVID-19 pandemic effects;current pandemic;Data;Data Science;Data Set;Disparity;Economics;Electronic Health Record;Epidemic;Equity;ethnic disparity;ethnic minority;Ethnic Origin;Frequencies;future pandemic;Goals;health disparity;health equity;Health system;high risk;HIV;HIV diagnosis;HIV Infections;Hospitalization;Housing;Immune System Diseases;implementation strategy;improved;Individual;insight;Interruption;Intervention;Laboratory Markers;Latinx;Latinx population;learning strategy;Machine Learning;Measures;Mediating;Mediation;Methods;minority communities;Modeling;multilevel analysis;next generation;Outcome;pandemic disease;Pathway interactions;Patients;Persons;Politics;Population;Population Attributable Risks;Positioning Attribute;post-COVID-19;pre-exposure prophylaxis;predictive modeling;Prevention;Prevention approach;Public Health;public health intervention;Race;racial disparity;Racial Equity;racial minority;Recording of previous events;repository;Research;response;Risk;SARS-CoV-2 infection;severe COVID-19;Sexually Transmitted Diseases;social;social determinants;social factors;social health determinants;social interventions;social vulnerability;statistical learning;Structural Racism;Testing;transmission process;United States National Institutes of Health;Vaccination;vaccine effectiveness;Viral

PROJECT_TITLE: The tale of two pandemics: Understanding racial and ethnic disparities from the collision of HIV and COVID-19 in the U.S.

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: LA JOLLA

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: The UCSD Genetics Training Program rigorously prepares an exceptional pool of students for professional careers in basic and applied research in life and health sciences. Our graduates succeed in academic institutions, non-profit research institutions, government agencies, biotechnology and pharmaceutical companies, and related industries that promote human health or scientific advancement. The overwhelming majority of our graduates remain in research-intensive or research-related careers that aim to promote and improve human health.

PI_NAMEs: HAMILTON, BRUCE A (contact)

PROGRAM_OFFICER_NAME: STAMM, JOYCE CHIN-CHIN NG

PROJECT_TERMS: Genetic;Training Programs

PROJECT_TITLE: UC San Diego Genetics Training Program

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - B[TWD-B]


ADMINISTERING_IC: EB

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

PHR: PROJECT NARRATIVE We have developed methods to evolve proteins continuously in the laboratory toward new biological activities. These methods offer tremendous potential for evolving next-generation gene editing tools and protein therapeutics to treat human diseases; however, they are limited by technical barriers that negatively impact their success rate, efficiency, and broader application. To address these limitations, we propose to develop powerful automation technologies that will dramatically increase the speed, scale, and wider adoption of these methods, and to use the resulting technologies to evolve two classes of proteins with therapeutic potential.

PI_NAMEs: KHALIL, AHMAD SAMIR (contact);LIU, DAVID R

PROGRAM_OFFICER_NAME: CHEN, JERMONT

PROJECT_TERMS: Address;Adopted;Adoption;Affinity;antibody engineering;arm;Automation;Bacteria;Bacteriophages;Binding;Binding Proteins;Biological;Biosensing Techniques;Biotechnology;cancer immunotherapy;Cells;cellular engineering;Chemicals;Clinical Treatment;Clustered Regularly Interspaced Short Palindromic Repeats;combinatorial;cost;design;Detection;Development;Dimensions;Directed Molecular Evolution;Disease;DNA;DNA Integration;Engineering;Evolution;Factor IX;gene editing technology;Generations;Genes;Genetic Diseases;Genome;genomic locus;Genomics;Genotype;Goals;Guide RNA;Head;Hemophilia B;Hepatocyte;Homologous Gene;Human;Human Cell Line;human disease;Human Genome;improved;interest;Laboratories;Ligands;loss of function;Mammalian Cell;mammalian genome;Medicine;metabolic engineering;Methods;miniaturize;Mission;Mutation;new technology;next generation;novel;operation;parallelization;Pathway interactions;Pharmaceutical Preparations;Population;Process;Protein Engineering;Proteins;Protocols documentation;Reporting;Robotics;Schedule;Scheme;Site;small molecule;Speed;Standardization;success;synthetic biology;System;Techniques;Technology;technology development;theories;Therapeutic;therapeutic genome editing;therapeutic protein;Toxin;Transgenes;Transposase;Variant;virtual;Work

PROJECT_TITLE: ePACE: automation platforms for adaptable and scalable continuous evolution of biomolecules with therapeutic potential

STUDY_SECTION: ISD

STUDY_SECTION_NAME: Instrumentation and Systems Development Study Section[ISD]


ADMINISTERING_IC: MD

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: LOS ANGELES

ORG_NAME: CHARLES R. DREW UNIVERSITY OF MED & SCI

PHR: Narrative CDU proposes to create a Learning Health Systems and Learning Health Communities Core to enhance the capacity to conduct cancer, HIV/AIDS, cardio-metabolic, mental health, substance abuse and health services research and increase the scientific workforce diversity.

PI_NAMEs: CARLISLE, DAVID M (contact)

PROGRAM_OFFICER_NAME: JONES, NANCY LYNNE

PROJECT_TERMS: Academic support;Address;Area;base;Bioinformatics;biomedical informatics;Biomedical Research;Biometry;Capital;cardiometabolism;career;Clinical;Clinical Services;Collaborations;college;Color;Communities;community engaged research;community engagement;Community Health;Community Healthcare;Education;empowerment;Endowment;Ensure;Environment;Equity;ethnic minority;Faculty;faculty community;flexibility;Foundations;Funding;Goals;Health Disparities Research;Health Policy;Health Services;Health Services Research;Health system;Healthcare;higher education;HIV;HIV/AIDS;Income;Infrastructure;Institution;Intellectual Property;Interdisciplinary Study;International;Learning;Malignant Neoplasms;marginalized community;Medicine;Mental Health;mid-career faculty;minority disparity;minority health;minority health disparity;Minority-Serving Institution;Mission;National Institute on Minority Health and Health Disparities;operation;Play;Policy Research;Postdoctoral Fellow;Privatization;Productivity;professor;programs;racial minority;recruit;Research;research faculty;Research Infrastructure;Research Institute;response;Role;Schools;Science;senior faculty;service engagement;skills;Solvents;student training;Students;Substance abuse problem;success;Training;Underrepresented Minority;United States;Universities;Urban Health;Work

PROJECT_TITLE: Charles R. Drew University of Medicine and Science Research Endowment Program


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Disability Research;Mental Health;Neurodegenerative;Neurosciences;Patient Safety;Prevention;Rehabilitation

ORG_CITY: PORTLAND

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE  Postoperative delirium (POD) and postoperative cognitive dysfunction (POCD) are the most common surgical complications experienced by older adults, and they are associated with increased hospital length of stay, early departure from the workforce, increased risk of Alzheimer’s disease, and mortality. Nearly 40% of surgical  patients are older adults, and as the surgical population ages faster than the U.S. population, anesthesiologists are poised to improve the health of older Americans by identifying strategies to prevent POD and POCD. Completing the proposed research will provide evidence that is readily translatable to clinical practice to aid the  choice of general anesthetic strategy to minimize the incidence of POD, POCD, and functional decline in older adults and improve patient-reported outcomes.

PI_NAMEs: SCHENNING, KATIE JO (contact)

PROGRAM_OFFICER_NAME: NELLISSERY, MAGGIE JACOB

PROJECT_TERMS: abeta oligomer;Active Learning;Affect;Age;Age Years;age-related disease;Aging;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease risk;American;Amyloid beta-Protein;Anesthesia procedures;Anesthesiology;Anesthetics;Anti-Inflammatory Agents;Award;Biological Markers;Blood;blood-based biomarker;career;career development;Clinical;clinical practice;Clinical Trials;Consensus;cost;cost effective;Data;Dedications;Delirium;Dementia;Development Plans;disability;Double-Blind Method;effective intervention;Elderly;Evidence based practice;experience;Exposure to;Friends;functional decline;functional disability;Functional disorder;functional improvement;functional status;General Anesthesia;General anesthetic drugs;Geriatrics;Goals;Health;Health Care Costs;high risk;Human;Impaired cognition;improved;In Vitro;in vivo;Incidence;Inflammatory;Inhalation;Inhalation Anesthesia;Inpatients;Institution;Intervention Trial;Interview;Intravenous;Intravenous Anesthesia;Investigation;Knowledge;Lead;Leadership;Length of Stay;Literature;Maintenance;medical specialties;Medicine;meetings;men;Mentors;Mentorship;Meta-Analysis;Modality;modifiable risk;mortality;multidisciplinary;Neurocognitive Deficit;neurocognitive test;neuroinflammation;neuron apoptosis;Neuronal Injury;neurotoxic;neurotoxicity;older adult;older patient;operation;Operative Surgical Procedures;Outcome;Outcomes Research;Participant;Patient Outcomes Assessments;Patient-Focused Outcomes;Patients;Perioperative;Perioperative Care;Personal Satisfaction;Pharmaceutical Preparations;Physicians;Plasma;Population;Positioning Attribute;post-operative cognitive dysfunction;postoperative delirium;Postoperative Period;preclinical study;prevent;Production;Property;Propofol;Public Health;Randomized;Research;Research Proposals;Risk;Risk Factors;Role;Scientist;secondary outcome;Severities;skills training;Surgical complication;tau-1;Techniques;Testing;Training;Translating;Venous blood sampling;Woman

PROJECT_TITLE: Optimizing anesthesia to prevent postoperative cognitive and functional decline in older adults


NIH_SPENDING_CATS: Behavioral and Social Science;Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Mental Health;Physical Activity;Physical Rehabilitation;Prevention;Prostate Cancer;Radiation Oncology;Rehabilitation;Urologic Diseases;Women's Health Research

PHR: Relevance There are nearly 7 million breast and prostate cancer survivors in the U.S. and most are married. Cancer threatens quality of life and mortality of survivors and their partners and strains their marriage. Our type 1 hybrid effectiveness implementation study will conduct a phase II trial to test a partnered exercise approach delivered during radiation treatment on physical and mental health of the dyad and will used a mixed-methods approach to gather information to guide future implementation of the program into routine clinical care.

PI_NAMEs: WINTERS-STONE, KERRI M (contact)

PROGRAM_OFFICER_NAME: ACEVEDO, AMANDA MARIE

PROJECT_TERMS: acceptability and feasibility;Address;Administrator;adverse outcome;Aftercare;Anxiety;Biometry;biopsychosocial;Breast Cancer survivor;cancer care;cancer diagnosis;Cancer Patient;Cancer Survivor;cancer therapy;Caring;Categories;Cessation of life;Chronic Disease;Clinic;Clinical;clinical care;clinical practice;Collaborations;Communication;Control Groups;cost;Couples;COVID-19;Data;design;Diagnosis;disability;Dose;Educational process of instructing;effectiveness/implementation study;effectiveness/implementation trial;efficacy testing;efficacy/implementation trial;Emotional;Exercise;exercise program;exercise training;experience;Face;falls;Fatigue;Feasibility Studies;fitness;follow-up;Fortification;future implementation;General Population;Health;Health Personnel;Heart Diseases;high risk;Hybrids;Hypertension;implementation science;improved;Individual;Inflammation;information gathering;innovation;Insulin Resistance;Intervention;intimate behavior;Malignant Breast Neoplasm;Malignant neoplasm of prostate;Malignant Neoplasms;Marriage;member;men;Mental Depression;Mental Health;Metabolic syndrome;Methods;Morbidity - disease rate;mortality;multidisciplinary;Nature;Newly Diagnosed;Obesity;Oncology;Outcome;Pathway interactions;Patient Care;Patients;phase II trial;physical conditioning;Physical Function;Physical Rehabilitation;Play;point of care;post intervention;prevent;Process;Process Measure;programs;prostate cancer survivors;Prostate Cancer therapy;Psyche structure;psychosocial;Publications;Qualitative Methods;Quality of life;Radiation Oncology;Radiation therapy;Randomized;randomized controlled design;Recommendation;remote delivery;remote technology;Reporting;Role;Sampling;satisfaction;Science;Self Efficacy;sex;Sleep;Social support;Spouses;Supportive care;Survivors;symptom management;Testing;theories;Time;Training;treatment as usual;usual care arm;Woman;Work

PROJECT_TITLE: A dyadic exercise approach to prevent declines in physical and mental health in couples during radiation treatment for cancer: a hybrid type I efficacy-implementation trial

STUDY_SECTION: CMGC

STUDY_SECTION_NAME: Clinical Management in General Care Settings Study Section[CMGC]


ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative Serum IgM reactive to common chemical adducts constitute a significant but largely unrecognized component of humoral immunity. Our studies propose to investigate their cellular source as well as their main housekeeping functions.

PI_NAMEs: ZORN, EMMANUEL  (contact)

PROGRAM_OFFICER_NAME: CASTLEMAN, MORIAH JOVITA

PROJECT_TERMS: Address;adduct;Adult;Age Months;Antigens;Apoptotic;Area;Autoimmune Diseases;B-cell receptor repertoire sequencing;B-Lymphocytes;Binding;Biological Assay;Biological Process;Bone Marrow;Cell membrane;Cell secretion;Cell surface;Cells;Characteristics;chemical group;Chemicals;Clone Cells;Collection;Complement;Complex;cytokine;early childhood;enzyme linked immunospot assay;Epitopes;experimental study;Exposure to;Flow Cytometry;Gut associated lymphoid tissue;high dimensionality;Housekeeping;Human;Humoral Immunities;Hypersensitivity;Idiopathic Thrombocytopenic Purpura;Immunity;Immunoglobulin G;Immunoglobulin Isotypes;Immunoglobulin M;in vivo;Incidence;Individual;Inflammation;Knowledge;Link;macromolecule;Malondialdehyde;Maps;Memory;Memory B-Lymphocyte;natural antibodies;Neonatal;neonate;Newborn Infant;oxidation;oxidized low density lipoprotein;pathogen;pathogenic bacteria;pathogenic virus;Patients;Phagocytes;Phenotype;Phosphorylcholine;Plasma Cells;Play;prevent;Process;Property;Proteins;Reaction;Regulation;Research;Role;Serum;single-cell RNA sequencing;Source;Specificity;Spleen;Systemic Lupus Erythematosus;Thymus Gland;Tissues;transcriptome;uptake

PROJECT_TITLE: Source and homeostatic functions of anti-adduct IgM in humans

STUDY_SECTION: CMIB

STUDY_SECTION_NAME: Cellular and Molecular Immunology - B Study Section[CMIB]


NIH_SPENDING_CATS: Drug Abuse (NIDA only);Neurosciences;Opioids;Substance Misuse

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Narrative:  Ketamine is an established anesthetic that can also treat depression, chronic pain, and opioid use disorder, but the mechanisms involved remain elusive. Recent evidence suggests that ketamine affects the opioid system, and this will be tested by examining both the short-term and long-term effects of ketamine.

PI_NAMEs: DEVI, LAKSHMI A (contact);FRICKER, LLOYD D;GOMES, IVONE ;MARGOLIS, ELYSSA ;WACKER, DANIEL

PROGRAM_OFFICER_NAME: VEMURI, KIRAN R V

PROJECT_TERMS: Absence of pain sensation;Acute;Acute Pain;Adenylate Cyclase;Affect;Analgesics;Anesthetics;Animals;antagonist;anti-depressive agents;antidepressant effect;Arrestins;beta-Endorphin;Binding;Biological;Biological Process;Brain;Brain region;Cell Surface Receptors;Cells;chronic pain;Clinical effectiveness;clinically relevant;comorbidity;Complex;Corpus striatum structure;Cryoelectron Microscopy;Cultured Cells;Data;delta opioid receptor;Disease;Dose;Dynorphins;economic cost;effective therapy;Electrophysiology (science);endogenous opioids;Fentanyl;Functional disorder;gamma-Aminobutyric Acid;General anesthetic drugs;Glutamate Receptor;GTP-Binding Proteins;Health;Hour;Human;Hypothalamic structure;in vivo;insight;kappa opioid receptors;Ketamine;Laboratories;Laboratory Finding;Leucine Enkephalin;Ligands;Location;Long-Term Effects;Major Depressive Disorder;Measures;Mediating;Membrane;Mental Depression;Methionine Enkephalin;molecular drug target;Morphine;mu opioid receptors;Mus;N-Methyl-D-Aspartate Receptors;Naltrexone;Neurons;Neuropeptides;Neurotransmitters;norketamine;novel therapeutics;Opioid;Opioid Antagonist;Opioid Peptide;Opioid Receptor;opioid use disorder;Pain;Peptides;Pharmaceutical Preparations;Pharmacology;Pharmacotherapy;Phosphotransferases;Plasma;positive allosteric modulator;Preparation;Production;Protein Precursors;radioligand;receptor;Receptor Inhibition;Receptor Signaling;receptor-mediated signaling;recruit;Rewards;Rodent;Role;Signal Transduction;Slice;social;Solid;Stereoisomer;Structure;Synapses;synergism;synthetic drug;System;Testing;Time;Tissues;Transducers;Ventral Tegmental Area

PROJECT_TITLE: Enhancement of the endogenous opioid system by ketamine

STUDY_SECTION: MCNP

STUDY_SECTION_NAME:
Molecular and Cellular Neuropharmacology Study Section
[MCNP]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Mental Illness;Physical Injury - Accidents and Adverse Effects;Prevention;Psychosis;Schizophrenia;Serious Mental Illness;Social Determinants of Health;Violence Research

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE The development of strategies and interventions for preventing or minimizing violent behavior in individuals with psychotic disorders has been limited, in part, by a lack of information about the effects of antipsychotic medications, and in particular clozapine, on violent acts in community settings. In this project, we will determine whether clozapine, when administered in real-world settings, decreases the risk for violent acts in individuals with schizophrenia at high risk for violence when compared to treatment with other antipsychotic medications, and investigate whether previously identified change mechanisms are operative in the effectiveness setting. Examining clozapine in this way will foster a better understanding of the effects of clozapine on violent acts in community settings and allow us to test a scalable intervention and service delivery approaches that can be broadly implemented using typically available resources, and as such has significant public health implications.

PI_NAMEs: KOPELOWICZ, ALEX J (contact)

PROGRAM_OFFICER_NAME: RUDORFER, MATTHEW V

PROJECT_TERMS: Address;Aggressive behavior;Alcohol consumption;Alcohols;Antipsychotic Agents;antisocial behavior;Behavior;blind;Clinical;Clinical Research;clinical research site;Clinical Trials;clinically relevant;Clozapine;Collaborations;community partners;community setting;community violence;Data;Delusions;Development;Diagnostic;Disparate;Effectiveness;effectiveness outcome;effectiveness study;efficacy trial;Ensure;Fostering;Future;high risk;Hostility;Human Resources;improved;Impulsivity;Individual;individual patient;interest;Intervention;intervention delivery;Interview;Link;Measures;Multi-Institutional Clinical Trial;Murder;Neurobiology;New York;open label;Outcome;Outcome Measure;Outpatients;Pathway interactions;Patients;Persons;Pharmaceutical Preparations;Populations at Risk;Positron-Emission Tomography;prevent;primary outcome;Property;Protocols documentation;psychopathic personality;Psychoses;psychotic;Psychotic Disorders;Public Health;Randomized;randomized, clinical trials;Research;Research Domain Criteria;Resources;Risk;Risk Reduction;Running;Safety;Sample Size;Schizophrenia;Sedation procedure;Self-Injurious Behavior;service delivery;Site;social stigma;Spectrum Analysis;substance use;Symptoms;Syndrome;Testing;Time;treatment as usual;treatment effect;Violence;violence prevention;Vulnerable Populations;Work

PROJECT_TITLE: 6//7 Clozapine for the Prevention of Violence in Schizophrenia: a Randomized Clinical Trial.


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Human Genome;Precision Medicine;Prostate Cancer;Urologic Diseases

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Project Narrative As highly effective, though non-curative, therapies for metastatic prostate cancer are now being used in earlier stages of disease, there is a critical need for new treatments in castrate resistant prostate cancer (mCRPC). We have identified Trop-2 as a high value target that can be expressed in treatment resistant prostate cancer. We will study biomarkers of Trop-2 in a clinical trial for men with mCRPC with an antibody drug conjugate that targets Trop-2. Integrated blood and tumor biopsies will be analyzed to identify novel predictive biomarkers.

PI_NAMEs: DEHM, SCOTT M.;LANG, JOSHUA MICHAEL (contact)

PROGRAM_OFFICER_NAME: MCKEE, TAWNYA C

PROJECT_TERMS: abiraterone;advanced prostate cancer;androgen independent prostate cancer;Androgen Metabolism;Androgen Receptor;Antibody-drug conjugates;AR gene;Automobile Driving;Biological;Biological Markers;Biopsy;Blood;Bypass;Cancer Patient;Castration;Cell surface;chemotherapy;Chromatin;Clinical;clinical efficacy;Clinical Trials;Combined Modality Therapy;Consensus;constitutive expression;Disease;Disease Resistance;docetaxel;effective therapy;Enhancers;enzalutamide;Epigenetic Process;epigenomics;Epithelial Cells;FDA approved;Future;Gene Amplification;Gene Expression Profiling;Gene Rearrangement;Generations;Genetic Transcription;Genomics;Goals;hormone therapy;Human;improved;In Vitro;in vivo;inhibitor;Life;liquid biopsy;Malignant neoplasm of prostate;Malignant Neoplasms;Medical;men;Metastatic Prostate Cancer;Molecular;Molecular Analysis;Mutation;Mutation Analysis;Neoplasm Circulating Cells;Neuroendocrine Cell;New Agents;novel;novel therapeutics;Pathway interactions;Patient Selection;Patients;pharmacodynamic biomarker;Phase II Clinical Trials;phase II trial;Phenotype;Poly(ADP-ribose) Polymerase Inhibitor;pre-clinical;preclinical study;predictive marker;programs;Progression-Free Survivals;prospective;radioligand;radiological imaging;Receptor Signaling;Regimen;Regulation;research study;Resistance;resistance mechanism;response;Sampling;single cell proteins;Solid Neoplasm;Specimen;Surface Antigens;TACSTD2 gene;targeted treatment;taxane;Testing;Therapeutic;therapeutic target;therapy resistant;Tissues;Transcription Alteration;Translational Research;Treatment Efficacy;treatment strategy;Trophoblastic Cell;tumor;Variant

PROJECT_TITLE: Molecular regulation and expression of Trop-2 in advanced prostate cancer: Identifying optimal therapeutic niches

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-TIO-D(01)Q]


ED_INST_TYPE: OVERALL MEDICAL

NIH_SPENDING_CATS: HIV/AIDS;Infectious Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

PHR: PROJECT NARRATIVE The development of curative approaches for HIV infection is now recognized as both a necessary and attainable goal. Hematopoietic stem cell transplantation has been shown to functionally cure HIV infection in two separate patients, but naturally CCR5-deficient donors were required. We propose here to use our non-human primate model of allogeneic hematopoietic stem cell transplantation to mimic CCR5 deficiency with a CCR5 blocking antibody for HIV cure and to then extend this approach to HIV+ individuals undergoing stem cell transplantation.

PI_NAMEs: SACHA, JONAH B. (contact)

PROGRAM_OFFICER_NAME: POON, BETTY

PROJECT_TERMS: Achievement;Allogenic;Antibodies;antiretroviral therapy;Berlin;Binding;Blocking Antibodies;cancer therapy;CCR5 gene;CD4 Positive T Lymphocytes;Cells;Chimerism;Clinical;clinical development;Clinical Trials;clinically relevant;cohort;conditioning;design;Development;Disease remission;Dose;Engraftment;Epidemic;extracellular;Failure;Funding;global health;Goals;Grant;Health Priorities;Hematologic Neoplasms;Hematopoietic Stem Cell Transplantation;HIV;HIV Antibodies;HIV Infections;Immune;Immune response;Immune system;Immunity;Individual;Infection;inhibitor;Interruption;isoimmunity;Knowledge;Length;leukemia;London;Macaca;Macaca fascicularis;Manufacturer;Measures;Mediating;mimicry;Modeling;Monitor;nonhuman primate;novel therapeutics;Patients;peripheral blood;Persons;pharmacologic;Phenocopy;Phenotype;Plasma;post-transplant;pre-clinical;Predisposition;purge;Recording of previous events;Rectum;Regimen;Role;Safety;sex;simian human immunodeficiency virus;SIV;small molecule;stem cell model;Stem cell transplant;T-Lymphocyte;Testing;Time;transplant model;Transplantation;Viral Load result;Viral reservoir;Viremia;Virus Replication;Work;Y Chromosome

PROJECT_TITLE: A nonhuman primate model of stem cell transplantation to understand determinants of post-transplant SIV clearance

STUDY_SECTION: HIVD

STUDY_SECTION_NAME: HIV Immunopathogenesis and Vaccine Development Study Section[HIVD]


ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Project Narrative  Chronic disease disease is a major cause of morbidity and mortality; therefore understanding the factors that contribute to kidney disease and ultimately lead to end-organ injury is important. This proposal uses an innovative mouse model and in vitro studies to determine the role of soluble (pro)renin receptor in chronic kidney disease. Findings from this study will establish the functional significance of this receptor, the mechanisms by which the injury effects are mediated and may help in developing a new therapeutic approach for kidney disease in the future.

PI_NAMEs: RAMKUMAR, NIRUPAMA  (contact)

PROGRAM_OFFICER_NAME: SADUSKY, ANNA BURKART

PROJECT_TERMS: Address;Adenine;Adult;Affect;Affinity Chromatography;Angiotensin II;Attenuated;autocrine;Binding;Biochemical;Blood Pressure;cardiovascular risk factor;Cell Culture Techniques;Cell membrane;Cell secretion;Cell surface;Cells;Chronic Disease;Chronic Kidney Failure;comparative;comparison control;CRISPR/Cas technology;Development;Diet;Disease;Disease Progression;Enzymes;Etiology;Fibrosis;Future;Gene Expression;Gene Expression Profiling;Genetic Transcription;Hypertension;hypertensive;In Vitro;in vivo;Inflammation;Inflammatory;inflammatory modulation;Inflammatory Response;Infusion procedures;Injury;Injury to Kidney;innovation;Interleukin-6;Kidney;Kidney Diseases;kidney fibrosis;Label;Length;Mass Spectrum Analysis;Mediating;Mitochondria;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;Mutagenesis;mutant;nano-string;nectin;novel;novel therapeutic intervention;organ injury;Oxidative Phosphorylation;paracrine;Pathogenesis;Pathway interactions;Patients;Persons;Physiological;Plasma;Population;Proteins;Proteomics;receptor;Receptor, Angiotensin, Type 1;Recombinants;Regulation;Renal function;Renin;Renin-Angiotensin-Aldosterone System;response;Role;Signal Pathway;Signal Transduction;Site;Structure;System;Techniques;Time;transcriptome sequencing;transcriptomics;Tubular formation;United States;Ureteral obstruction;Vascular Endothelial Cell

PROJECT_TITLE: Soluble (pro)renin receptor regulation of kidney fibrosis

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Genetics;Immunotherapy;Networking and Information Technology R&D (NITRD);Regenerative Medicine

ORG_NAME: NORTHWESTERN UNIVERSITY

PHR: Project Narrative Engineered cell therapies represent an exciting frontier in medicine, and fully realizing the promise of this approach will require technologies and tools that enable bioengineers to efficiently design, build, and evaluate customized cellular functions that meet specific clinical needs. Towards that goal, this project will develop synthetic biology technologies and computational design tools for engineering cells to sense, evaluate, and respond to their environment in useful ways. Such capabilities will facilitate the development of safer and more effective treatments in areas including cancer, autoimmune disease, and regenerative medicine.

PI_NAMEs: BAGHERI, NEDA ;LEONARD, JOSHUA NATHANIEL (contact);MANGAN, NIALL

PROGRAM_OFFICER_NAME: FEHR, TUBA HALISE

PROJECT_TERMS: Achievement;Address;Area;Autoimmune Diseases;Award;Behavior;Biological;Biomedical Engineering;Biosensing Techniques;cancer immunotherapy;cancer therapy;Cell Line;Cell Physiology;Cell Therapy;Cells;cellular engineering;Chromatin;Clinical;Communities;Complex;Computer Assisted;computer framework;Computer-Aided Design;computerized tools;Cues;Data;design;Development;effective therapy;engineered T cells;Engineering;engineering design;Environment;Epigenetic Process;Evaluation;Exhibits;frontier;functional outcomes;Genetic;genetic architecture;Genetic Transcription;Genome;Goals;graphical user interface;Human;Imagination;improved;insight;Knowledge;Libraries;Malignant Neoplasms;Mammalian Genetics;Maps;Medicine;Memory;Methods;Modeling;multi-scale modeling;Natural Killer Cells;novel;novel therapeutics;Population;Positioning Attribute;Process;programs;Progress Reports;Protein Engineering;Proteins;receptor;Regenerative Medicine;Reporting;Research;Research Personnel;Resources;Safety;sensor;Site;Software Framework;success;synthetic biology;System;Technology;technology development;Therapeutic;Time;tool;transcription factor;Tumor Markers;Work

PROJECT_TITLE: Design-driven engineering of robust mammalian sense-and-respond functions: from parts to programs


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Biotechnology;Eye Disease and Disorders of Vision;Genetics;Neurodegenerative;Neurosciences

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: NARRATIVE Recent studies in mice suggest that specific types of retinal ganglion cells, the neurons that degenerate in glaucoma, are more susceptible to injury. However, translating these findings to the human condition is not straightforward since the mouse and human eye differ in several major ways, including the ocular structures and types of retinal ganglion cells found in the two species. Here we propose a detailed multi-modal assessment of the mechanisms underlying ganglion cell susceptibility in a highly clinically relevant model of glaucoma, which will lead to improved understanding of the disease, novel targets for earlier diagnosis and treatment, and in turn, better options for glaucoma patients to preserve and potentially improve their vision.

PI_NAMEs: FORTUNE, BRAD ;OU, YVONNE  (contact);SIVYER, BENJAMIN M

PROGRAM_OFFICER_NAME: SONG, HONGMAN

PROJECT_TERMS: Address;Adult;Affect;Anatomy;Cell Death;cell injury;Cell Therapy;cell type;Cells;Central Nervous System;clinical development;clinical translation;clinically relevant;Communities;Data;Dendrites;density;design;Development;Diagnostic;Disease;Early Diagnosis;Early treatment;Electrophysiology (science);Ensure;Exhibits;Experimental Models;Eye;fovea centralis;ganglion cell;Gene Expression;Gene Expression Profile;gene therapy;Genes;Genetic Transcription;Glaucoma;Goals;Human;human disease;improved;in vivo;Individual;injured;Injury;Inner Plexiform Layer;innovation;insight;Intervention;Knowledge;Label;Laboratories;Learning;Macaca mulatta;macula;Maps;Modeling;Molecular;Molecular Analysis;Morphology;multi-electrode arrays;multimodality;Mus;Nerve Degeneration;neural circuit;Neuroanatomy;Neurons;neuroprotection;new therapeutic target;nonhuman primate;novel;novel diagnostics;novel strategies;novel therapeutics;Online Systems;patch sequencing;Pathologic;Patients;Pattern;Physiologic Intraocular Pressure;Physiological;Physiology;Predisposition;preservation;presynaptic;Primates;Protocols documentation;Reaction;repaired;Research Personnel;Resources;response to injury;Retina;Retinal Diseases;Retinal Ganglion Cells;retinal neuron;Rod;Rodent;Rodent Model;Shapes;sight restoration;Site;Specificity;Staging;Structure;Synapses;Testing;Therapeutic Intervention;Tissue-Specific Gene Expression;transcriptome;Translating;translation to humans;Translations;Vision;Vision research;Visual

PROJECT_TITLE: Retinal circuit disassembly in primate glaucoma

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]


NIH_SPENDING_CATS: Clinical Research;Nutrition;Physical Injury - Accidents and Adverse Effects;Wound Healing and Care

ORG_CITY: LITTLE ROCK

ORG_NAME: ARKANSAS CHILDREN'S HOSPITAL RES INST

ORG_STATE: AR

PHR: PROJECT NARRATIVE Elevated energy expenditure and metabolic dysfunction are significant clinical problems facing critically ill patients such as those with severe burns. The goal of this research program is to advance our understanding of the role of the mitochondrion in the metabolic stress response to burn trauma. By leveraging innovative animal models and studying patients, we will generate new knowledge that will aid in the development of strategies that reduce suffering and promote the recovery of burn survivors.

PI_NAMEs: PORTER, CRAIG  (contact)

PROGRAM_OFFICER_NAME: CHAO, CHIEN-CHUNG

PROJECT_TERMS: Adipose tissue;Animal Model;Antioxidants;Award;Bioenergetics;biological adaptation to stress;Blood specimen;Burn injury;Burn Trauma;Carrier Proteins;Circulation;Clinical;Critical Illness;Data;Deuterium Oxide;Development;Dose;Energy Metabolism;Goals;Homeostasis;in vivo;innovation;insight;Insulin Resistance;Isotope Labeling;Knowledge;lipid metabolism;Measurement;Measures;Mediator;Membrane Potentials;Metabolic;Metabolic dysfunction;Metabolic stress;Metabolism;Mitochondria;Mitochondrial DNA;Mitochondrial Proteins;Modeling;Morbidity - disease rate;Muscular Atrophy;novel;oxidation;Patients;pre-clinical;programs;protein degradation;Protons;Quality of life;Reactive Oxygen Species;Recovery;Research;Research Personnel;Respiratory physiology;response;restoration;Rodent Model;Role;severe burns;Skeletal Muscle;Stress;Superoxides;Survivors;systemic inflammatory response;Temperature;Testing;Tissue Sample;Tissues;Trauma;United States

PROJECT_TITLE: The Role of the Mitochondrion in the Metabolic Stress Response to Burn Trauma

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-H(55)R]


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Diabetes;Digestive Diseases;Genetics;Liver Disease;Nutrition

ORG_NAME: JOSLIN DIABETES CENTER

PHR: NARRATIVE In type 2 diabetes, accumulation of excess fats in the liver can progress to liver dysfunction or cirrhosis. Studies in this proposal identify a novel mechanism for regulation of fat metabolism in liver tissue that protects against the toxic effects of excess fat. Results of this work could lead to new therapies for one of the most common complications of diabetes.

PI_NAMEs: SCHAFFER, JEAN E. (contact)

PROGRAM_OFFICER_NAME: BURGESS-BEUSSE, BONNIE L

PROJECT_TERMS: Acceleration;Adult;Age;Autophagocytosis;Biogenesis;Cell Culture Techniques;Cell Death;Cells;Cholesterol;Chronic Kidney Failure;Complications of Diabetes Mellitus;conditional knockout;Data;Diet;dietary;Disease;endoplasmic reticulum stress;Enzymes;Fatty acid glycerol esters;Fatty Acids;Fibrosis;Fructose;Functional disorder;Genetic Screening;genome-wide;Germ Lines;Health;Heart failure;Hepatic;Hepatocyte;High Fat Diet;Inflammation;insight;Introns;Islets of Langerhans;Knock-out;Laboratories;Link;lipid metabolism;Lipids;Liver;Liver Cirrhosis;Liver Dysfunction;Liver Mitochondria;loss of function;Lysosomes;Maintenance;Mediator;Messenger RNA;Metabolic;Metabolic Diseases;metabolic fitness;Methylation;Mitochondria;mitochondrial fitness;mitochondrial metabolism;Modeling;Modification;Molecular;mouse model;mRNA Translation;Mus;new therapeutic target;non-alcoholic fatty liver disease;Non-Insulin-Dependent Diabetes Mellitus;Nonesterified Fatty Acids;novel;novel therapeutics;Nucleotides;Nutrient;Organ;Oxidative Stress;Oxidative Stress Induction;Oxygen Consumption;Palmitates;prevent;Regulation;Resistance;response;Ribosomal Proteins;Ribosomal RNA;ribosome profiling;Ribosomes;RNA, Ribosomal, 28S;Site;Small Nucleolar RNA;Structure;Testing;Tissues;Toxic effect;trafficking;Trans Fats;translational potential;Translational Regulation;Triglycerides;Untranslated RNA;Up-Regulation;Wild Type Mouse;Work

PROJECT_TITLE: Lipotoxicity and Maintenance of Metabolic Health

STUDY_SECTION: NMHD

STUDY_SECTION_NAME: Nutrition and Metabolism in Health and Disease Study Section[NMHD]


ORG_CITY: SAINT LOUIS

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Most human diseases arise due to disruptions in basic cellular and molecular processes caused by mutations in one's DNA or the presence of a pathogen in one's body. Our program trains students in the core concepts and methods of cell and molecular biology, preparing them to uncover basic insight into the cell and molecular processes that normally control cell growth and development but that when perturbed can lead to diseased states. With better knowledge of these processes and more trained biomedical scientists in the workforce, we can improve our ability to detect, treat, and defeat many crippling human diseases.

PI_NAMEs: TRUE-KROB, HEATHER L (contact)

PROGRAM_OFFICER_NAME: NELSON, SHAKIRA M

PROJECT_TERMS: Cellular biology;Molecular Biology;Training Programs

PROJECT_TITLE: Training Program in Cellular and Molecular Biology

STUDY_SECTION_NAME: Training and Workforce Development Study Section - A[TWD-A]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Cancer;Genetics

ORG_CITY: NEW ORLEANS

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: PROJECT NARRATIVE It is critical to understand how cells prevent genomic mutations and rearrangements that drive tumor development. The goal of the proposed research is to understand how defects in replication interact with the environment and contribute to genomic alterations. Thus, the proposed research is relevant to the part of the NIH’s mission that pertains to developing fundamental knowledge that will enhance human health and reduce the burdens of illness.

PI_NAMEs: PURSELL, ZACHARY F (contact)

PROGRAM_OFFICER_NAME: SHAUGHNESSY, DANIEL

PROJECT_TERMS: Acceleration;Address;Alleles;Biochemistry;Biological Models;BRCA2 gene;BRCA2 Mutation;burden of illness;Bypass;cancer genome;cancer type;Catalytic Domain;Cell model;Cells;checkpoint therapy;Clinical Data;Clustered Regularly Interspaced Short Palindromic Repeats;Cytosine;Data;Deamination;Defect;Development;Disease;DNA biosynthesis;DNA Damage;DNA lesion;DNA Polymerase II;DNA Repair;DNA replication fork;DNA Sequence Alteration;DNA-Directed DNA Polymerase;driver mutation;Environment;Exonuclease;Failure;Functional disorder;Gene Rearrangement;gene repair;Genes;Genetic;Genetic Engineering;Genetically Engineered Mouse;genome database;Genome Stability;Genomic Instability;Genomics;Goals;Health;Heterozygote;Human;Human Cell Line;human DNA;immune checkpoint blockade;In Vitro;innovation;insight;Intervention;Investigation;Knowledge;Laboratories;Left;Link;loss of function;Malignant Neoplasms;Measures;Mission;Modeling;Mouse Cell Line;Mus;Mutagenesis;mutant;Mutate;Mutation;neoantigens;neoplastic cell;Normal Cell;novel;Nuclear;Organoids;Pathway interactions;Phenotype;Polymerase;Positioning Attribute;prevent;PTEN gene;Publishing;repaired;replication stress;Research;response;System;Testing;Therapeutic;Therapeutic Intervention;Time;tumor;tumorigenesis;tumorigenic;United States National Institutes of Health;Variant;Work

PROJECT_TITLE: Investigation of human DNA polymerase epsilon variants

STUDY_SECTION: CE

STUDY_SECTION_NAME: Cancer Etiology Study Section[CE]


PHR: PROJECT NARRATIVE The With No Lysine (WNK) kinases regulate important processes in many different organs of the body, including the kidney, and excess activity of these kinases can lead to high blood pressure, high blood potassium levels, and poor outcomes after stroke. These conditions increase morbidity and mortality. The proposed research will examine new mechanisms for WNK regulation. Ultimately, this could lead to the development of new drugs targeting this pathway, with beneficial effects on human health.

PI_NAMEs: RODAN, AYLIN RACHEL (contact)

PROGRAM_OFFICER_NAME: KETCHUM, CHRISTIAN J

PROJECT_TERMS: adverse outcome;Alanine;Animal Model;Binding;Binding Sites;Biochemical;biological adaptation to stress;Biological Assay;Biophysics;Blood;Calorimetry;Cerebrovascular Disorders;Cesium;Chloride Ion;Chlorides;Chronic Kidney Failure;collaborative approach;conformer;Data;design;Development;dimer;Drosophila genus;Drosophila melanogaster;Epithelium;Equilibrium;experience;Funding;Future;Goals;Grant;Hand;Health;Human;human model;hyperkalemia;Hypertension;In Vitro;in vitro activity;in vivo;inhibitor;innovation;insight;Ion Transport;Kidney;Kidney Diseases;Lysine;Malpighian Tubules;Maps;Measures;Methods;Modeling;Molecular;Molecular Conformation;Molecular Genetics;monomer;Morbidity - disease rate;mortality;Mouse Protein;Mutagenesis;mutant;Mutation;new therapeutic target;novel;novel therapeutic intervention;Organ;Outcome;Oxidative Stress;paralogous gene;Pathologic;Pathway interactions;Phosphorylation;Phosphotransferases;Physiological;Physiology;Positioning Attribute;post stroke;Potassium;Process;Proline;Protein Isoforms;Publishing;Regulation;Renal function;Renal Tissue;Research;Research Personnel;Roentgen Rays;Role;salt sensitive hypertension;Scaffolding Protein;side effect;Signal Pathway;Signal Transduction;Structure;Testing;Therapeutic;Titrations;tool;translational impact

PROJECT_TITLE: Regulation of WNK signaling by potassium and Mo25: structure, function and physiology

STUDY_SECTION: KUFD

STUDY_SECTION_NAME: Kidney and Urological Systems Function and Dysfunction Study Section[KUFD]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_CITY: ATLANTA

ORG_DEPT: BIOLOGY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE The proposed research will define how transcription factors integrate genomic information to regulate nuclear domains during animal development. The research is relevant to public health because gene regulatory domain initiation and maintenance are critical to both development and disease. Thus, the proposed research is relevant to the NIH mission of developing scientific resources to help prevent disease.

PI_NAMEs: RIEDER, LEILA ELIZABETH (contact)

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TERMS: 3-Dimensional;Address;Animals;Biocompatible Materials;Cell Nucleus;Cells;Centromere;Chromatin;Code;Collaborations;Creativeness;Cues;Deposition;Development;Disease;DNA Sequence;Drosophila genus;Drosophila melanogaster;egg;Embryo;Embryonic Development;Epigenetic Process;Event;Genes;Genetic;Genome;Genomics;Goals;Histones;insight;Laboratories;Maintenance;Mission;Nuclear;Peptide Initiation Factors;prevent;Proteins;Public Health;recruit;Regulation;Repetitive Sequence;Reporter;Research;Resources;rRNA Genes;Signal Transduction;Source;System;telomere;tool;transcription factor;Transgenes;United States National Institutes of Health;Work;zygote

PROJECT_TITLE: Developmental regulation of nuclear domains

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


FUNDING_MECHANISM: SBIR-STTR RPGS

ORG_CITY: CARLSBAD

ORG_NAME: BIOSPYDER TECHNOLOGIES, INC.

PHR: Project Narrative  The analysis of rare and biologically important cell subtypes presents a common challenge in development and disease, where phenotypically variant cell populations can significantly affect the response to therapy and impact patient outcomes. High-throughput single-cell sequencing has proven to be the most successful approach for identifying unique cell subtypes and resolving complex cellular heterogeneity The vision of BioSpyder is to commercially launch a low cost, high-throughput and targeted single-cell multi-omic platform, TempO-LINC, that provides numerous advantages over existing commercial platforms and will enable new studies relying on single-cell sequencing in basic, biopharma, clinical, translational and applied markets.

PI_NAMEs: SELIGMANN, BRUCE E. (contact)

PROGRAM_OFFICER_NAME: CHO, THOMAS Y

PROJECT_TERMS: Address;Adoption;Affect;Automation;Bar Codes;Benchmarking;Bioinformatics;Biological Assay;Biological Markers;Biological Sciences;Cell Nucleus;Cells;Chromium;Clinical;combinatorial;commercial launch;commercialization;Communicable Diseases;Complex;Computer software;cost;Data;Data Analyses;data quality;Detection;Development;Differentiated Gene;Disease;Dissociation;Foundations;Gene Expression;Gene Expression Profiling;Genes;graphical user interface;Heterogeneity;Immunology;improved;instrument;Intellectual Property;interest;Malignant Neoplasms;Manuals;Maps;Marketing;Measurement;Measures;Methods;Mitochondria;Molecular;mRNA Expression;multiple omics;novel;oligo (dT);open source;Pathway interactions;Patient-Focused Outcomes;Peripheral Blood Mononuclear Cell;Pharmaceutical Preparations;Phase;Phenotype;Population;Positioning Attribute;prevent;Proliferating;protein expression;Proteins;Protocols documentation;reconstruction;Research;Research Personnel;research study;Reverse Transcription;Ribosomes;Running;sample fixation;Sampling;sequencing platform;single cell analysis;single cell sequencing;Small Business Innovation Research Grant;Solid;statistics;success;Technology;Tissues;tool;Transcript;transcriptome;treatment response;Update;user-friendly;Validation;Variant;Vision;Work

PROJECT_TITLE: TempO-LINC high throughput high sensitivity single cell gene expression profiling assay Ph II


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Data Science;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Precision Medicine

ORG_CITY: WORCESTER

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: Our genetic background underpins our responses to a wide variety of diseases including infection, autoimmune diseases, and cancer; machine learning and deep-sequencing based genomics technologies are revolutionizing our understanding of immunobiology and contribute to clinical predictions and recommendations. We propose to draw on the wealth of genetic and epigenetic data and our expertise in large-scale computational genomics to build a data integration and visualization platform for supporting a wide range of immune-mediated disease research. Project

PI_NAMEs: WENG, ZHIPING  (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: 2019-nCoV;3-Dimensional;Architecture;ATAC-seq;Atlases;Autoimmune Diseases;Autoimmune Responses;autoinflammatory diseases;base;Biological Assay;Biology;Blood Cells;cell type;Cells;Cellular Assay;Chromatin;clinical phenotype;clinical predictors;clinically relevant;Collaborations;Collection;Communicable Diseases;Communities;community engagement;Community Outreach;computer framework;computerized tools;computing resources;Data;Data Analyses;data integration;data repository;data visualization;Databases;deep sequencing;design;Development;Disease;DNA Methylation;Elements;empowerment;Enhancers;Epigenetic Process;epigenetic regulation;epigenome;experience;Gene Expression Regulation;gene function;Genes;Genetic;genetic makeup;genetic variant;Genome;genome wide association study;genomic tools;Genomics;Goals;Hematopoiesis;Heritability;histone modification;Human;human disease;Human Genetics;Human Genome;Immune;immune cell infiltrate;Immune response;Immune system;Immune System Diseases;Immunize;Immunobiology;Immunologics;Immunologist;immunoregulation;improved;improved outcome;Individual;Infection;informatics tool;insight;interactive visualization;knowledgebase;Letters;Literature;Machine Learning;machine learning method;Malignant Neoplasms;Maps;Mediating;member;Metadata;Modeling;molecular phenotype;Multiomic Data;novel;Online Systems;Pathway interactions;Patient Care;Persons;precision medicine;predict clinical outcome;predictive modeling;Prognosis;promoter;public repository;Recommendation;Registries;Regulatory Element;Research;Research Personnel;Research Project Grants;Resolution;Resources;response;Sampling;Signal Transduction;single cell ATAC-seq;single cell technology;single-cell RNA sequencing;Symptoms;syntax;Techniques;Technology;Time;Tissues;tool;trait;transcription factor;Transcriptional Regulation;transcriptome;transcriptome sequencing;Untranslated RNA;Variant;Virus;Visual;Visualization;Visualization software

PROJECT_TITLE: iSCREEN: An Integrative Data and Annotation Platform of Gene Regulation for Immune-mediated Disease Research


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Neurosciences;Physical Injury - Accidents and Adverse Effects;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: YALE UNIVERSITY

PHR: PUBLIC HEALTH RELEVANCE: Current diagnosis of spinal cord injury (SCI) mainly relies on X-ray, CT, and MRI, and lacks a quantitative method to evaluate the disease severity and to predict the disease projection. This project is to develop a sensitive, reliable, and quantitative PET imaging method for the diagnosis and prognosis of SCI. It will also allow for the noninvasive longitudinal tracking of SCI recovery and progression and guiding the choice of the therapeutics and the assessment of the effects in clinical trials of disease-modifying interventions.

PI_NAMEs: CAI, ZHENGXIN  (contact)

PROGRAM_OFFICER_NAME: BAMBRICK, LINDA LOUISE

PROJECT_TERMS: Affinity;Age;Alzheimer's Disease;Animal Model;Animals;Antibody Therapy;behavior test;Behavioral;Binding;Binding Sites;Biological Assay;Biological Markers;Brain;Chest;Clinic;Clinical;Clinical Management;clinical translation;Clinical Trials;Cognitive;Contusions;cost;density;Diagnosis;Disease;dosimetry;drug testing;efficacy evaluation;Electron Microscopy;Emotional;Epilepsy;Evaluation;Event;experimental study;Functional disorder;gastrointestinal system;Glycoproteins;Histologic;Histology;Human;Image;imaging agent;imaging approach;imaging modality;imaging study;Immunohistochemistry;improved;In Vitro;in vitro Assay;in vivo evaluation;Injury;injury recovery;Intervention;Levetiracetam;Ligands;Literature;Macaca mulatta;Magnetic Resonance Imaging;Measures;Mental Depression;Methods;Modality;Modeling;Molecular Biology;Monkeys;Motor;neural;Neuronal Plasticity;neuropsychiatric disorder;non-invasive imaging;nonhuman primate;novel;Outcome;outcome prediction;Parkinson Disease;Patients;Persons;Physiological;Positron-Emission Tomography;Prognosis;public health relevance;quantitative imaging;radiotracer;Rattus;receptor;Recovery;Research;respiratory;Rodent;Rodent Model;routine imaging;Scanning;Schizophrenia;Sensory;Severities;Severity of illness;Signal Transduction;Specificity;Spinal Cord;Spinal Cord Contusions;spinal cord imaging;Spinal cord injury;Spinal cord injury patients;Stroke;Synapses;Synaptic Vesicles;Synaptophysin;Testing;Therapeutic;Therapeutic Effect;therapeutic evaluation;Time;Tissues;tool;Tracer;Translating;treatment effect;Treatment outcome;treatment response;United States;uptake;urinary;Validation;Western Blotting;X-Ray Computed Tomography

PROJECT_TITLE: SV2A PET in Spinal Cord Injury Imaging

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


NIH_SPENDING_CATS: Genetics;HIV/AIDS;Infectious Diseases

ORG_CITY: MAYWOOD

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: LOYOLA UNIVERSITY CHICAGO

PHR: Project Narrative The underlying mechanisms of HIV-1 nuclear import remain poorly described. In this application, we will define HIV-1 nuclear import mechanisms using assays which block the specific nuclear import pathways and determine how this influences the nuclear trafficking and integration sites in subsequent steps of infection.

PI_NAMEs: CAMPBELL, EDWARD M (contact)

PROGRAM_OFFICER_NAME: MCDONALD, DAVID JOSEPH

PROJECT_TERMS: Affect;Architecture;Area;Automobile Driving;Binding;Binding Proteins;Biochemical;Biological Assay;Biology;Capsid;Capsid Proteins;Cell Nucleus;cell type;Cells;Chromatin;Cleavage And Polyadenylation Specificity Factor;Complex;Cyclophilin A;Cytoplasm;Data;Dimerization;Electron Microscopy;Engineering;Environment;Event;experimental study;Genes;Genetic Transcription;Genome;High-Throughput Nucleotide Sequencing;Histones;HIV;Image;imaging approach;Individual;Infection;Infection prevention;insight;Integration Host Factors;integration site;Interphase Cell;Knowledge;Lentivirus;Life Cycle Stages;Light;Lighting;Maps;Mediating;Methodology;Microscopy;Monitor;mutant;Mutation;novel;Nuclear;Nuclear Accidents;Nuclear Import;Nuclear Localization Signal;Nuclear Pore;Nuclear Pore Complex;Nuclear Pore Complex Proteins;Nuclear Protein;Nuclear Translocation;Pathway interactions;Pharmaceutical Preparations;Population;Pore Proteins;Primate Lentiviruses;Process;Proviruses;reactivation from latency;Research;Reverse Transcription;Ribonucleoproteins;Role;Series;spatiotemporal;Staging;Structure;Techniques;therapeutic development;Therapeutic Intervention;trafficking;Viral;Viral Genome;Viral Physiology;Virus;Virus Diseases;Virus Integration;Visualization

PROJECT_TITLE: Defining the nuclear import pathways of HIV-1

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIB-T(90)]