NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Clinical Research;Heart Disease;Kidney Disease;Prevention

ORG_CITY: PHILADELPHIA

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: The goals of this project are to develop novel dynamic longitudinal functional models and to apply them to the electrocardiographic (ECG) data that are measured repeatedly over time in the Chronic Renal Insufficiency Cohort (CRIC) study of individuals with chronic kidney disease (CKD). We will also develop real-time risk prediction algorithms to identify individuals at high- risk of cardiovascular diseases (CVD). While motivated by the ECG data collected from CRIC study, the proposed methods are general, and can be applied to other electronic health data of different diseases.

PI_NAMEs: DEO, RAJAT ;GUO, WENSHENG  (contact);YANG, WEI

PROGRAM_OFFICER_NAME: KUNZ, JOHN FREDERIC

PROJECT_TERMS: Algorithms;Atrial Fibrillation;Cardiovascular Diseases;cardiovascular disorder risk;Cardiovascular Models;cardiovascular risk factor;Cardiovascular system;Cessation of life;Chronic Kidney Failure;Chronic Kidney Insufficiency;Classification;Clinical;clinical center;clinical risk;cohort;Cohort Studies;Communities;Computer software;convolutional neural network;Data;Data Analyses;data sharing;Development;Diabetes Mellitus;Digestive System Disorders;Disease;Electrocardiogram;electronic health data;Electronic Health Record;Equation;Event;feature selection;Funding;Goals;Health system;Heart failure;high risk;high risk population;Hospitalization;Individual;Kidney Diseases;Lead;Measures;Methods;model building;Modeling;Myocardial Infarction;novel;Patient Recruitments;Patients;Pattern;Pennsylvania;Performance;prediction algorithm;predictive modeling;Principal Component Analysis;Procedures;prospective;Risk Factors;risk prediction model;Site;Statistical Methods;Statistical Models;Stroke;Time;Universities;user friendly software;user-friendly;Validation;Visit

PROJECT_TITLE: Dynamic Longitudinal Functional Models with Applications to the CRIC Study

STUDY_SECTION: BMRD

STUDY_SECTION_NAME: Biostatistical Methods and Research Design Study Section[BMRD]


ADMINISTERING_IC: AG

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: SAN FRANCISCO

ORG_COUNTRY: UNITED STATES

ORG_DEPT: NEUROLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE Aggregation of the protein tau is thought to drive several neurodegenerative diseases, including Alzheimer's Disease, that lack disease-modifying therapeutics. The goal of this proposal is to gain a comprehensive understanding of how the misfolding and aggregation of tau is controlled by a combination of its sequence and its cellular environment in human neurons. Completion of this proposal has the potential to provide unique insight into fundamental properties of protein misfolding in the brain and identify novel therapeutic targets for treating Alzheimer's Disease and other tau-related neurodegenerative diseases.

PI_NAMEs: SAMELSON, AVI JACOB (contact)

PROGRAM_OFFICER_NAME: YANG, AUSTIN JYAN-YU

PROJECT_TERMS: Alzheimer's Disease;American;Animal Model;Antibodies;Behavior;Biological;Biological Process;Biophysics;Brain;career;Categories;Cellular biology;Characteristics;Collaborations;Complex;CRISPR interference;crosslink;Deposition;Development;Disease;Disease Progression;effective therapy;Electron Transport;Environment;Etiology;Event;Functional disorder;functional genomics;Genes;genome-wide;Goals;Human;In Vitro;in vivo;Induced pluripotent stem cell derived neurons;innovation;insight;Kinetics;Licensing;Link;Mass Spectrum Analysis;Mentors;Mitochondria;Molecular;Molecular Conformation;Mutation;mutation screening;Neurodegenerative Disorders;Neurons;new technology;new therapeutic target;novel;novel therapeutic intervention;Onset of illness;Pathologic;Peptide Hydrolases;Pharmaceutical Preparations;Phase;Phosphorylation;Positioning Attribute;Post-Translational Protein Processing;Postdoctoral Fellow;Property;protein aggregation;protein misfolding;Proteins;Proteolysis;Proteomics;Research;Research Personnel;Scientist;skills;Spectrum Analysis;Structure;Symptoms;tau aggregation;tau interaction;tau mutation;tau Proteins;tau-1;Tauopathies;Techniques;Therapeutic;therapeutically effective;Training;Work

PROJECT_TITLE: Functional Characterization of Tau Mutation and Post-translational Modifications

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development Facilitating The Transition to Independence Study Section[AGCD-1]


ADMINISTERING_IC: HL

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Disorders;Cardiovascular;Clinical Research;Neurosciences

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: NARRATIVE Increased arterial stiffness has been associated with indicators of damage to the brain including presence of white matter hyperintensity, infarctions, brain atrophy as assessed with magnetic resonance imaging (MRI). Ultrasound is a first-line imaging modality for evaluation of vascular geometry and flow because of its real-time capabilities, but many scanners do not have the capabilities to measure arterial mechanical properties in an accurate, quantitative manner. Successful completion of this project will characterize the relationship between ultrasound-based measurement of carotid artery mechanical properties and MRI measured indicators of brain health.

PI_NAMEs: URBAN, MATTHEW WILLIAM (contact)

PROGRAM_OFFICER_NAME: LIU, SONGTAO

PROJECT_TERMS: absorption;Acoustics;Address;arterial stiffness;Arteries;Behavior;Blood Vessels;Brain;brain health;brain morphology;brain tissue;Cardiovascular Diseases;cardiovascular effects;Cardiovascular system;Carotid Arteries;cerebral atrophy;Classification;Clinic;Clinical;cohort;Complex;Computer Models;Data;Data Analyses;data reduction;Detection;detection method;Development;disease classification;Elasticity;Engineering;Evaluation;Experimental Designs;Frequencies;Geometry;Goals;Grant;Health;imaging modality;Impaired cognition;improved;Infarction;Magnetic Resonance Imaging;mathematical model;Measurement;Measures;mechanical properties;Mechanics;Medicine;Methodology;Methods;Modeling;Modernization;Morphology;Motion;MRI Scans;multidisciplinary;Noise;Pathologic;Patients;predictive tools;preservation;Process;Progress Reports;Property;Publications;Pulsatile Flow;Radiation;Radiology Specialty;Research;Research Project Grants;Role;Signal Transduction;Source;Techniques;temporal measurement;Testing;Text;Time;Tissues;tool;Translations;transmission process;ultrasound;vascular factor;viscoelasticity;waveguide;White Matter Hyperintensity

PROJECT_TITLE: Measuring arterial material properties using wave-based approaches with ultrasound and computational models

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Brain Disorders;Conditions Affecting the Embryonic and Fetal Periods;Fetal Alcohol Spectrum Disorders (FASD);Intellectual and Developmental Disabilities (IDD);Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Substance Misuse

ORG_CITY: PROVIDENCE

ORG_NAME: RHODE ISLAND HOSPITAL

ORG_STATE: RI

PHR: This R37 competing renewal application is to use an established experimental model of fetal alcohol spectrum disorder (FASD) to characterize the mechanisms of long-term brain white matter (WM) pathology. Using multi- pronged innovative approaches, the proposed research will evaluate impairments in WM insulin/IGF signaling that are critical to survival, maturation, and function of oligodendrocytes (OLs); OLs generate and maintain myelin, enabling efficient neuronal conductivity for cognitive-motor functions. The research plan includes analysis of circulating extracellular vesicles that likely reflect FASD brain WM pathology and responses to treatment and have prospects for clinical application via high throughput non-invasive diagnostics and therapeutic monitoring.

PI_NAMEs: DE LA MONTE, SUZANNE M. (contact)

PROGRAM_OFFICER_NAME: MURRAY, GARY

PROJECT_TERMS: Address;Adhesions;Adolescence;Adolescent;Adolescent Development;Adverse effects;alcohol effect;alcohol exposure;Alcohols;Axon;Behavior;Biological Assay;Biological Markers;Brain;Brain Diseases;Brain Pathology;Cell Death;cell motility;Cells;Central Nervous System Diseases;Ceramides;Cerebrum;Chronic;clinical application;clinically relevant;Cognitive;Data;Development;Diagnosis;Disease;Dose;dysmyelination;Electron Microscopy;Enzyme-Linked Immunosorbent Assay;Ethanol;exosome;Experimental Models;experimental study;extracellular vesicles;Failure;Female;Fetal Alcohol Exposure;Fetal Alcohol Spectrum Disorder;FRAP1 gene;Functional disorder;Funding;Genes;Human;Immunohistochemistry;Impairment;in vivo;Injury;innovation;Insulin;Insulin-Like Growth Factor I;life span;Link;lipidomics;Lipids;Long-Evans Rats;Long-Term Effects;Maintenance;male;Mediating;Messenger RNA;Metabolic;Metabolism;migration;Mixed Function Oxygenases;Modeling;Monitor;Motor;motor deficit;Myelin;neurobehavioral;Neurocognitive;neuroinflammation;Neuronal Migration Disorder;neuronal survival;Neurons;Non-Invasive Detection;noninvasive diagnosis;notch protein;novel;Oligodendroglia;Oxidative Stress;Pathology;Pathway interactions;peripheral blood;PIK3CG gene;postnatal;Predisposition;Proteins;Regulation;Research;Role;Serum;sex;Signal Transduction;Slice;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;Sphingolipids;Sphingomyelins;stem;Structure;success;Sulfoglycosphingolipids;Synapses;Therapeutic;Therapeutic Intervention;therapeutic target;tool;treatment response;white matter

PROJECT_TITLE: FASD Inhibition of ASPH-Notch Mediates Adolescent Cerebral White Matter Pathology-Potential Utility of Non-invasive Extracellular Vesicle Assays


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_DEPT: PATHOLOGY

PHR: Alzheimer’s disease (AD) is a serious public health issue without treatment, although scientists are making genetic discoveries that could lead to new therapeutic strategies. In the Y6-10 funding period, GCAD will assemble and harmonize sequencing data from more than 80,000 genomes as a community resource, and coordinate analysis of these data. GCAD will also assemble and harmonize functional genomics data which will be integral to identifying genes as candidate drug targets.

PI_NAMEs: SCHELLENBERG, GERARD DAVID (contact);WANG, LI-SAN

PROGRAM_OFFICER_NAME: YAO, ALISON Q

PROJECT_TERMS: Abbreviations;Affect;African American population;Age;Alleles;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Artificial Intelligence;Asian population;ATAC-seq;Award;Benchmarking;Calibration;candidate identification;Caregivers;Caribbean Hispanic;Cells;ChIP-seq;Clinical;Cognitive;cognitive system;collaborative environment;Collection;Communities;computer code;Computer software;computing resources;Copy Number Polymorphism;corticobasal degeneration;Data;Data Analyses;Data Collection;data repository;Data Set;deep learning;deep neural network;Disease;Documentation;drug candidate;Drug Targeting;Elderly;Environment;Epigenetic Process;Equilibrium;Ethnic Population;European;exome;exome sequencing;file format;Fostering;Frontotemporal Dementia;functional genomics;Funding;gene network;Genes;Genetic;Genetic Annotation;Genetic Diseases;genetic variant;Genome;genome analysis;genome wide association study;genome-wide linkage;genomic data;Genomics;Goals;Grant;Hi-C;Individual;Infrastructure;insertion/deletion mutation;International;learning network;Lewy Body Dementia;LGR5 gene;Machine Learning;Maps;metabolomics;Methods;Methylation;Molecular Conformation;National Heart, Lung, and Blood Institute;National Human Genome Research Institute;National Institute on Aging;neural network;Not Hispanic or Latino;novel therapeutic intervention;Parkinson's Dementia;Pathway interactions;Patients;Persons;Phase;phenotypic data;Precision Medicine Initiative;Predisposition;prevent;Prevention;Process;programs;Progressive Supranuclear Palsy;Proteomics;Public Health;quality assurance;Quality Control;reference genome;Research;Research Personnel;Resources;Risk Factors;Sampling;Scientist;Sequence Alignment;Single Nucleotide Polymorphism;Source;Systems Analysis;therapeutic candidate;therapeutic target;trait;Trans-Omics for Precision Medicine;transcriptome sequencing;United States;Variant;whole genome;Work

PROJECT_TITLE: Genome Center for Alzheimer's Disease (GCAD)


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences

PI_NAMEs: SCHELLENBERG, GERARD DAVID (contact)

PROJECT_TERMS: Abbreviations;Alzheimer's Disease;Alzheimer's Disease Core Center;Alzheimer's disease related dementia;Artificial Intelligence;Award;Chromatin;cognitive system;Collaborations;Communities;computerized data processing;Consent;corticobasal degeneration;dashboard;Data;Data Analyses;data exchange;data harmonization;Data Protection;Data Set;data sharing;data storage site;database of Genotypes and Phenotypes;deep learning;deep neural network;Development;Disease;Documentation;Epigenetic Process;European;exome;follow-up;Fostering;Frontotemporal Dementia;functional genomics;Funding;gene discovery;Genetic;Genetic Diseases;Genome;genomic data;Genomics;Grant;Health Sciences;Institutional Review Boards;International;Joints;Lead;Lewy Body Disease;Machine Learning;meetings;member;Meta-Analysis;metabolomics;Methods;Molecular;Molecular Conformation;National Institute on Aging;neural network;neuroimaging;Newsletter;Paralysed;Parkinson's Dementia;Pathogenesis;phenotypic data;Pick Disease of the Brain;Principal Investigator;Process;Progressive Supranuclear Palsy;Proteomics;Protocols documentation;Provider;Publications;Quality Control;Reporter;Research;Research Personnel;Schedule;single-cell RNA sequencing;Site;SNP array;Source;symposium;Systems Analysis;Teleconferences;Telephone;trait;United States National Institutes of Health;University Health Services;Variant;web site;whole genome;Work;working group

PROJECT_TITLE: Administrative Core A


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Bioengineering;Clinical Research;Crohn's Disease;Digestive Diseases;Genetic Testing;Genetics;Inflammatory Bowel Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Precision Medicine;Prevention

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: PROJECT NARRATIVE This project will apply innovative machine learning methods to develop clinically-relevant computational models which analyze genetic and morphological signatures of Crohn’s disease to objectively and accurately predict specific outcomes of disease. This work is needed because predicting clinically-relevant outcomes of this debilitating autoimmune inflammatory disease at the time of diagnosis is currently impossible. Successful completion of this work will establish a bench-to-bedside machine learning platform which uses clinical metadata along with deep features of Crohn’s disease from patient-derived biopsies, thus improving clinical management of one of the most chronic, costly, and consequential diseases in the US.

PI_NAMEs: SYED, SANA  (contact)

PROGRAM_OFFICER_NAME: RAVICHANDRAN, VEERASAMY

PROJECT_TERMS: accurate diagnostics;Address;adverse outcome;age group;Age Years;Algorithms;Anemia;Autoimmune;Automobile Driving;Behavior;bench to bedside;Benchmarking;biobank;biomedical imaging;Biopsy;Cells;Childhood;Chromosome Mapping;Chronic;Classification;Clinical;clinical care;Clinical Management;clinical phenotype;clinical practice;clinical predictors;clinically relevant;cohort;Complex;Complication;Computer Models;cost;Crohn's disease;Data;Data Set;Development;Diagnosis;Diagnostic;Disease;Disease Management;Disease Outcome;disease phenotype;Disease Progression;Disease Resistance;Early treatment;Enrollment;Evaluation;feature detection;Fistula;Functional disorder;Future;Gastrointestinal Diseases;Gastrointestinal tract structure;Gene Expression;Gene Expression Profile;Genes;Genetic;genetic signature;Goals;Health;Histology;Histopathology;Image Analysis;improved;Incidence;individual patient;individualized medicine;Inflammatory;innovation;Intervention;Knowledge;Literature;Machine Learning;machine learning method;machine learning model;machine learning prediction;Malabsorption Syndromes;Maps;Metadata;Methodology;Methods;Microscopic;model building;Modeling;Molecular;morphological criteria;Morphology;Mucous Membrane;Newly Diagnosed;novel;Operative Surgical Procedures;Outcome;outcome prediction;Pathologic;Patients;Pattern;Pediatric Crohn's disease;Penetration;Performance;personalized diagnostics;personalized intervention;personalized medicine;Phenotype;precision medicine;predictive modeling;predictive tools;Predictive Value;prevent;Prevention;preventive intervention;prognostic;prospective;Prospective cohort;psychosocial;Publishing;recruit;Relapse;Reporting;Research;Resolution;response;Review Literature;Risk;risk prediction model;Sensitivity and Specificity;Severities;single-cell RNA sequencing;Slide;spatial integration;standard of care;Testing;Therapeutic Intervention;Time;Tissue Extracts;Tissues;TNF gene;Training;transcriptomics;Translations;treatment response;Visualization;Work

PROJECT_TITLE: Predicting Clinical Phenotypes in Crohn's Disease Using Machine Learning and Single-Cell 'omics

STUDY_SECTION: KNOD

STUDY_SECTION_NAME: Kidney, Nutrition, Obesity and Diabetes Study Section[KNOD]


ADMINISTERING_IC: CA

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Cancer;Digestive Diseases;Liver Cancer;Liver Disease;Orphan Drug;Rare Diseases

ORG_CITY: RALEIGH

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: NORTH CAROLINA STATE UNIVERSITY RALEIGH

ORG_STATE: NC

PHR: Relevance to Public Health While there have been many advances in the treatment of liver cancer over the past half century, approximately 85% of patients with this disease will die within five years of diagnosis. Integrated time nanosecond pulse irreversible electroporation (INSPIRE) is a new cancer therapy which uses ultrashort electrical pulses designed for the treatment of inoperable liver cancers. This proposal aims to develop the instrumentation and protocols necessary to implement INSPIRE clinically and demonstrate the safety, efficacy and reproducibility of the treatment in a relevant spontaneous large animal model of disease.

PI_NAMEs: SANO, MICHAEL BENJAMIN (contact)

PROGRAM_OFFICER_NAME: OBCEMEA, CEFERINO H

PROJECT_TERMS: Ablation;Abscopal effect;adaptive immune response;Admission activity;Affect;Aftercare;Algorithms;Animal Disease Models;Animal Model;Animals;anti-cancer;Antitumor Response;Apoptotic;Applications Grants;aspirate;Biological;Biological Assay;Biomedical Engineering;Biophysics;Blood specimen;Blood Vessels;cancer cell;cancer therapy;Canis familiaris;Cell Death;Cell membrane;Cells;Charge;chemotherapy;Clinical;Coagulative necrosis;cohort;Complex;Dangerousness;Data;design;Development;Diagnosis;Disease;Dose;effective therapy;electrical property;Electrodes;Electronics;Electroporation;Electroporation Therapy;experimental study;Feedback;Fine needle aspiration biopsy;Fire - disasters;Flow Cytometry;follow-up;Generations;Genomics;Goals;heat injury;Heating;Heterogeneity;Histologic;In Vitro;in vivo;in vivo Model;Inflammatory;instrumentation;Life;Liver;Liver neoplasms;lymph nodes;Malignant neoplasm of liver;Malignant Neoplasms;mechanical properties;Membrane;migration;minimally invasive;Modality;Modeling;Morphology;mortality;nanosecond;Necrosis;neoplastic cell;Normal Cell;novel;optimal treatments;Organ;Outcome;Output;Patients;peripheral blood;Physiologic pulse;Physiological;pre-clinical;preclinical evaluation;preservation;prevent;Primary carcinoma of the liver cells;Primary Neoplasm;Production;Prognosis;Protocols documentation;Public Health;Radiation therapy;Recurrence;Reproducibility;Research Project Grants;Resectable;Resected;Safety;safety assessment;sensor;Series;Shapes;Solid;Solid Neoplasm;Source;Structure;survival outcome;System;Temperature;Testing;therapy design;therapy outcome;Time;Tissues;Toxic effect;Treatment Efficacy;treatment optimization;Treatment outcome;treatment planning;Treatment Protocols;tumor;tumor ablation;tumor growth;Unresectable;voltage;X-Ray Computed Tomography

PROJECT_TITLE: Development of an INSPIRE System for the Treatment of Inoperable Liver Tumors

STUDY_SECTION: IGIS

STUDY_SECTION_NAME: Imaging Guided Interventions and Surgery Study Section[IGIS]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Precision Medicine

PI_NAMEs: NAJ, ADAM CHRISTIAN (contact)

PROJECT_TERMS: Accounting;Admixture;Alzheimer's Disease;Alzheimer's Disease Core Center;Alzheimer's disease related dementia;analysis pipeline;Back;Benchmarking;Biological Assay;Biometry;case control;cloud based;Cloud Computing;cluster computing;Collaborations;Communities;computerized data processing;Data;Data Analyses;data quality;data repository;Data Set;Data Sources;design;Development;Disease;Elasticity;endophenotype;Ethnic Origin;Family;follow up assessment;Genetic;Genome;genome wide association study;Genomics;Genotype;Heterogeneity;heterogenous data;insertion/deletion mutation;Institution;Joints;Meta-Analysis;Output;Performance;phenotypic data;Process;Production;Protocols documentation;quality assurance;Quality Control;Race;Reporting;Research Personnel;Sampling;Sensitivity and Specificity;Source;Statistical Data Interpretation;Testing;Trans-Omics for Precision Medicine;Update;Validation;Variant;Work

PROJECT_TITLE: Core C- Biostatistics and Data Analysis Core


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Genetics;Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: LA JOLLA

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: We have identified a gene (stathmin-2) whose expression is suppressed in almost all examples of the fatal paralytic disease ALS and half the cases of the second most frequent dementia (frontotemporal dementia or FTD). We now seek to determine what stathmin-2 does to support neuronal regeneration, how its expression is controled, and how reduction in it affects motor neuron or cognitive disease. Outcomes of these efforts will provide key insights for understanding basic aspects of axonal and synaptic neurobiology and for evaluating whether maintaining or restoring stathmin-2 is an attractive therapeutic option in sporadic ALS and FTD.

PI_NAMEs: CLEVELAND, DON W (contact);LAGIER-TOURENNE, CLOTILDE ;MARSALA, MARTIN

PROGRAM_OFFICER_NAME: GUBITZ, AMELIE

PROJECT_TERMS: Affect;Amyotrophic Lateral Sclerosis;Antisense Oligonucleotides;Axon;axon regeneration;Axotomy;beta Tubulin;Binding;Binding Sites;C9ORF72;Cells;Coculture Techniques;Cognition Disorders;CRISPR screen;Custom;Cytoplasmic Protein;Dementia;Denervation;dimer;Disease;DNA-Binding Proteins;Flow Cytometry;Frontotemporal Dementia;frontotemporal lobar dementia amyotrophic lateral sclerosis;functional restoration;Genes;Genetic;Genetic Screening;genome editing;genome-wide;Growth Cones;Guide RNA;Hereditary Disease;High-Throughput RNA Sequencing;Human;induced pluripotent stem cell;Induced pluripotent stem cell derived neurons;Inherited;Injections;insight;Introns;Libraries;Link;loss of function;Maintenance;Messenger RNA;Microtubule Stabilization;Microtubules;Motor Neuron Disease;motor neuron function;Motor Neurons;mRNA Precursor;Mus;Muscle;Mutation;Natural regeneration;nerve supply;Neurobiology;Neuromuscular Junction;neuron regeneration;neuronal cell body;Neurons;Nuclear;Optical Methods;Optics;Outcome;palmitoylation;Paralysed;Pathogenesis;Pathology;Polyadenylation;Post-Translational Protein Processing;premature;prevent;protein TDP-43;Proteins;repaired;restoration;RNA;RNA Sequences;RNA Splicing;Role;Site;small hairpin RNA;sporadic amyotrophic lateral sclerosis;stathmin;Synapses;synergism;Therapeutic;therapeutic target;Tubulin;Variant

PROJECT_TITLE: Determining stathmin-2 function and potential as a therapeutic target in ALS/FTD


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences

PI_NAMEs: WANG, LI-SAN  (contact)

PROJECT_TERMS: Alzheimer's Disease;Alzheimer's Disease Core Center;Alzheimer's disease related dementia;Automobile Driving;Biostatistics Core;ChIP-seq;Cloud Computing;cloud platform;Communities;computer code;computer infrastructure;Computer software;computerized data processing;Data;data harmonization;data management;data quality;Data Set;data sharing;data storage site;Deposition;design;distributed data;Documentation;Elasticity;Ensure;Environment;exome;exome sequencing;follow-up;functional genomics;gene interaction;Genes;Genetic;Genetic Research;genetic variant;Genome;genome wide association study;genomic data;Genotype;Haplotypes;Image;in silico;Information Dissemination;Information Technology;insertion/deletion mutation;Joints;Output;Pathway Analysis;Phase;Phenotype;phenotypic data;Process;Production;programs;Protocols documentation;Qualifying;Quality Control;repository;Research;Research Personnel;Source;Source Code;Testing;transcriptome sequencing;Variant;web site;whole genome;Work

PROJECT_TITLE: CORE B-Data Management, Harmonization, and Information Transfer Core


ADMINISTERING_IC: HD

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Brain Disorders;Intellectual and Developmental Disabilities (IDD);Neurosciences

ORG_CITY: CHAPEL HILL

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: Narrative Individuals with neurodevelopmental disorders, such as autism, intellectual disability, and fetal alcohol syndrome, often have severe impairments that require lifelong care, resulting in a substantial burden to affected individuals, their families, and their communities. The complexity of these conditions demands an integrated strategy that cuts across traditional research boundaries between the behavioral and basic biological sciences, including the boundaries between animal and human studies, as well as the boundaries between the laboratory and real-world applications. In this postdoctoral research training program in neurodevelopmental disorders, we propose an integrated, interdisciplinary training program that will prepare researchers to interface across disciplines and to make transformative advances for the betterment of individuals with neurodevelopmental disorders.

PI_NAMEs: PHILPOT, BENJAMIN D (contact);SHEN, MARK D

PROGRAM_OFFICER_NAME: KAU, ALICE S

PROJECT_TITLE: Postdoctoral Research in Neurodevelopmental Disorders


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

ORG_CITY: BALTIMORE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Narrative Cardiac arrhythmias are common in older age and strongly linked to diabetes. State-of-the art leadless “patch” ECG and continuous glucose monitoring technology provide novel means to evaluate the link between disordered glucose patterns and the occurrence of cardiac arrhythmias in adults with type 2 diabetes. The proposed project will provide evidence-based guidance regarding how low, high, and variable glucose may contribute to the occurrence of cardiac arrhythmias and subsequent health outcomes in the setting of diabetes.

PI_NAMEs: CHEN, LIN YEE;SELVIN, ELIZABETH  (contact)

PROJECT_TERMS: Acute;Address;adjudication;Adult;Affect;aged;Arrhythmia;Atherosclerosis Risk in Communities;Atrial Fibrillation;Atrial Premature Complexes;Atrial Tachycardia;Awareness;Cardiac;cardiovascular risk factor;Cardiovascular system;Cessation of life;Clinical;Clinical Data;cognitive function;Communities;Continuous Glucose Monitor;Data;Diabetes Mellitus;Diagnosis;Disease;Electrocardiogram;Event;evidence base;follow-up;frailty;Frequencies;Glucose;Glycosylated hemoglobin A;Goals;Health;Health Status;Heart;Heart Atrium;heart rate variability;heart rhythm;High Prevalence;human old age (65+);Hyperglycemia;Hypoglycemia;Impaired cognition;International Classification of Disease Codes;Lead;Link;Measures;Mediating;Methods;Monitor;monitoring device;mortality;Non-Insulin-Dependent Diabetes Mellitus;novel;older adult;Outcome;Pattern;Pharmaceutical Preparations;Physical assessment;Physical Function;physical impairment;Population;Prevalence;prognostic significance;prospective;Recommendation;recruit;Research;Risk Factors;Role;Sample Size;System;Technology;Testing;Variant;Ventricular Arrhythmia;Ventricular Premature Complexes;Ventricular Tachycardia;Visit

PROJECT_TITLE: Glucose patterns and cardiac arrhythmias in older adults with diabetes

STUDY_SECTION: CHSB

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology B Study Section[CHSB]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics

ORG_DEPT: BIOCHEMISTRY

PHR: Relevance To function appropriately and prevent disease states, all cells in the human body must be able to regulate what proteins they express in response to environmental cues or need. RNA processing, including alternative splicing, polyadenylation and mRNA stability, represent pervasive mechanisms for regulating protein expression and cellular function in response to extracellular triggers. The studies in this proposal seek to elucidate the regulatory pathways and molecular mechanisms by which changes in environment regulate RNA processing, and to determine the consequences of such regulation for maintaining proper cellular function and human health.

PI_NAMEs: LYNCH, KRISTEN W (contact)

PROGRAM_OFFICER_NAME: CZAPLINSKI, KEVIN

PROJECT_TERMS: Alternative Splicing;Antigens;Apoptosis;Area;Biological Models;Cell Death;cell growth;Cell Physiology;Cells;Cellular biology;Complex;Cues;Disease;effector T cell;Environment;Event;experimental study;extracellular;Funding;Gene Expression;gene function;Goals;Health;Human;Human body;Individual;Inflammation;insight;Interferons;link protein;Messenger RNA;Molecular;mRNA Stability;novel;Pathway interactions;Polyadenylation;prevent;protein expression;Proteins;Proteome;Regulation;Regulatory Pathway;Research;response;RNA Processing;RNA-Binding Proteins;Shapes;Signal Induction;Signal Pathway;signal processing;Signal Transduction;System;T-Cell Activation;T-Lymphocyte;Transcriptional Regulation;Translational Regulation;Work

PROJECT_TITLE: Signal-Induced Regulation of Alternative RNA Processing

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-D(55)R]


ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

PHR: Narrative We have discovered a previously unknown signal transduction mechanism in which bacteria deliver the C-terminus of a large exoprotein into the cytoplasm of neighboring cells where it binds to an immunity protein and the complex activates a large mobile element that defines a new class of transposon. In this system, a circular, extrachromosomal intermediate is formed that causes a change in gene expression that results in the induction of cooperative behaviors such as biofilm formation. We plan to determine the molecular mechanisms underlying this contact-dependent signaling and DNA transposition phenomenon and to investigate its link with horizontal gene transfer and the evolution of sociomicrobiological behavior. .

PI_NAMEs: COTTER, PEGGY A (contact)

PROGRAM_OFFICER_NAME: KEANE-MYERS, ANDREA

PROJECT_TERMS: Animals;Antibiotic Resistance;Antibiotics;Bacteria;Behavior;Binding;Biological;Burkholderia;Cells;Communities;Community Developments;Complex;Cooperative Behavior;Cytoplasm;Development;Disease;DNA;Elements;Environment;Evolution;gene discovery;Gene Expression;Genes;Gram-Negative Bacteria;Growth;hookah;Horizontal Gene Transfer;Human;Immunity;Insecta;Link;Mediating;Medical Device;Microbial Biofilms;Modeling;Molecular;Mucous Membrane;novel strategies;Paste substance;pathogenic bacteria;Phenotype;Plant Roots;Play;prevent;Production;Proteins;Role;Shellfish;Signal Transduction;Signaling Protein;Surface;System;transmission process

PROJECT_TITLE: Contact-dependent signaling and DNA transposition in Burkholderia

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-K(55)R]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Genetics;Human Genome;Ovarian Cancer;Prevention;Rare Diseases;Women's Health Research

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: PROJECT NARRATIVE Double-stranded DNA breaks (DSBs) can cause gross chromosomal rearrangements, which are the hallmark of all forms of cancer. The overall goal of our research is to study the events that lead to DSB formation and the mechanisms that cells use for DSB repair, in the hope that this research will eventually lead to a better understanding of how might be able to prevent or cure cancer.

PI_NAMEs: GREENE, ERIC C (contact)

PROGRAM_OFFICER_NAME: MACARTHUR, LINDA

PROJECT_TERMS: Address;BRCA2 gene;Cells;Chromosomal Rearrangement;Chromosomes;Complex;Defect;DNA;DNA biosynthesis;DNA Damage;DNA Double Strand Break;DNA Repair;DNA strand break;Embryo;Event;Genes;genetic information;Genetic Predisposition to Disease;Genome;genome integrity;Goals;Hereditary Malignant Neoplasm;homologous recombination;Human;Individual;Link;Malignant Breast Neoplasm;Malignant neoplasm of ovary;Malignant Neoplasms;Microscopy;Monitor;Mus;Mutation;Natural regeneration;Optics;Outcome;Pathway interactions;prevent;Process;programs;Proteins;Rad51 recombinase;recruit;Regulation;repaired;Research;Sequence Homologs;single molecule;Single-Stranded DNA;Technology;Time;Visualization

PROJECT_TITLE: Mechanisms of Genome Integrity


ED_INST_TYPE: SCHOOLS OF PHARMACY

PHR: NARRATIVE Antigen specific tolerance towards type-1 (insulin dependent) diabetes can provide a long-term cure for the disease without the need for administration of exogenous insulin. We propose the use of microparticles to reprogram the immune system’s response against the islet cells by creating antigen specific tolerance to mitigate the harmful autoimmune response.

PI_NAMEs: AINSLIE, KRISTY M (contact)

PROGRAM_OFFICER_NAME: SPAIN, LISA M

PROJECT_TERMS: Abbreviations;Acetals;Acids;acquired immunity;Affect;American;Animal Model;Antibodies;Antigen Presentation;Antigen Targeting;Antigen-Presenting Cells;Antigens;Autoantigens;Autoimmune Diseases;Autoimmune Responses;Autoimmunity;B-Lymphocytes;Beta Cell;biodegradable polymer;blood glucose regulation;CD4 Positive T Lymphocytes;Cells;Cellular Immunity;Child;Chromogranin A;Clinic;Clinical;Clinical Research;Coupled;Cyclosporine;Data;Dendritic Cells;Dependence;design;Dexamethasone;Dextrans;Diabetes Mellitus;diabetic;diabetogenic;Disease;DNA cassette;Dose;effector T cell;Encapsulated;Engineering;Eragrostis;Evaluation;Formulation;Foundations;FOXP3 gene;Generations;Goals;Histocompatibility Antigens Class II;Immune;immune function;Immune mediated destruction;immune modulating agents;Immune response;Immunity;Immunology;Immunosuppressive Agents;Immunotherapy;In Vitro;in vivo;Inbred NOD Mice;Incidence;Individual;Insulin;insulin dependent diabetes mellitus onset;Insulin-Dependent Diabetes Mellitus;Internal Ribosome Entry Site;Islet Cell;Kidney Diseases;Kinetics;lymph nodes;Macrophage;Measures;Mediating;Metabolic Control;Modeling;mouse model;Mouse Strains;Mus;nano;Nature;nephrotoxicity;Neuropathy;Newly Diagnosed;Non obese;novel vaccines;Ovalbumin;Pancreas;particle;Particle Size;particle therapy;Particulate;Patients;peptide based vaccine;Peptides;peptidomimetics;Periodicity;Phagolysosome;Pharmaceutical Preparations;Phenotype;Play;Polymers;pre-clinical;prevent;Prevention;programs;Proinsulin;Property;protective efficacy;Qualifying;Reading;Recurrence;Regulatory T-Lymphocyte;Remission Induction;Research;response;Retinal Diseases;Role;Self Tolerance;Sirolimus;System;T cell regulation;T cell therapy;T-Cell Receptor;T-Lymphocyte;Testing;trafficking;Transgenic Mice;Transgenic Organisms;Treatment Efficacy;uptake;Vascular Diseases

PROJECT_TITLE: Formulation to Generate Tolerance Towards Type 1 Diabetes

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

ORG_CITY: STILLWATER

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: OKLAHOMA STATE UNIVERSITY STILLWATER

ORG_STATE: OK

PHR: Project Narrative This predoctoral training program at Oklahoma State University will support excellence in the training of talented biomedical sciences doctoral students from diverse backgrounds, and will prepare them for successful careers in biomedical research.

PI_NAMEs: LOVERN, MATTHEW ;LOVERN, PAMELA C (contact);LUTTER, ERIKA ILDIKO

PROGRAM_OFFICER_NAME: BLATCH, SYDELLA ANNE

PROJECT_TERMS: Oklahoma;Universities

PROJECT_TITLE: G-RISE at Oklahoma State University

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - D[TWD-D]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Neurosciences;Precision Medicine;Prevention;Psychosis;Schizophrenia;Serious Mental Illness

ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: A substantial proportion of early psychosis EP individuals show minimal symptom reduction despite receiving the full range of evidence-based practices provided by coordinated specialty care (CSC). Currently, clinicians have no way to predict which EP individuals entering CSC will respond and who will not. In this project we will leverage recent progress in the development of pathophysiologically informed MRI based imaging biomarkers along with novel computational image analysis, to develop a precision medicine tool that can identify early psychosis patients entering CSC who are at high risk for non-response and thereby inform clinical decision making to optimize the recovery of young individuals following the onset of psychotic illness.

PI_NAMEs: CARTER, CAMERON S. (contact)

PROGRAM_OFFICER_NAME: WIJTENBURG, SARAH ANDREA

PROJECT_TERMS: Adjuvant;Admission activity;Anti-Inflammatory Agents;Behavioral;Biological Markers;Brain;candidate marker;Caring;Clinical;Clinical assessments;clinical decision-making;clinically significant;Clozapine;Cognition;Cognitive;cognitive control;Coordinated Specialty Care;Data;Decision Making;deep learning;Development;Diffusion Magnetic Resonance Imaging;Disease;Dopamine;Drug Prescriptions;duration of untreated psychosis;Early identification;early psychosis;Effectiveness;Enrollment;Evidence based practice;experience;explainable artificial intelligence;Functional disorder;Functional Magnetic Resonance Imaging;Future;Goals;gray matter;high risk;Image;Image Analysis;imaging biomarker;indexing;Individual;ineffective therapies;insight;Intervention;Link;Magnetic Resonance Imaging;Measurement;Measures;medication compliance;Methods;Midbrain structure;Modeling;neural;neuroimaging;neuroinflammation;neuromelanin;neurophysiology;Noise;novel;Parietal;Parkinson Disease;Participant;Patients;Performance;personalized medicine;Pharmaceutical Preparations;Phase;Positron-Emission Tomography;precision medicine;predicting response;Prediction of Response to Therapy;Prefrontal Cortex;Process;Property;Protocols documentation;Psychoses;psychosocial;Psychotherapy;Psychotic Disorders;Publishing;Recovery;reduce symptoms;Research;responders and non-responders;Sampling;Scanning;Schizophrenia;Series;standard of care;substance use;support tools;System;Testing;Time;tool;transfer learning;Treatment outcome;treatment responders;treatment response;water diffusion;white matter

PROJECT_TITLE: Pathophysiology Informed Biomarkers of Treatment Response in Early Psychosis (PIB)


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Clinical Research;Eye Disease and Disorders of Vision;Macular Degeneration;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: Aurora

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Age-related macular degeneration (AMD) is a vision threatening disease of the elderly. We expect our study will show an important role for circulating inflammatory biomarkers in AMD. This study will ultimately hasten a personalized approach to the management of patients with the intermediate form of AMD.

PI_NAMEs: LYNCH, ANNE M. (contact)

PROGRAM_OFFICER_NAME: SHEN, GRACE L

PROJECT_TERMS: Address;Advanced Development;Affect;age related biomarkers;Age related macular degeneration;Anti-Inflammatory Agents;Biological Markers;Blindness;Blood;Blood specimen;C-reactive protein;chemokine;Chronic;Chronic Disease;circulating biomarkers;Clinical;clinical risk;cohort;Colorado;comorbidity;Complement;Complement Activation;complement system;cytokine;Data;Development;Disease;DNA;Drusen;Early identification;Elderly;epidemiologic data;Epidemiology;Event;Exudative age-related macular degeneration;Future;Genes;Genetic;Genetic Risk;genetic risk factor;genetic variant;geographic atrophy;Goals;healthy lifestyle;high risk;high risk population;imaging biomarker;Individual;Inflammaging;Inflammation;Inflammatory;inflammatory marker;insight;Interruption;Intervention;Knowledge;Link;Longitudinal cohort;macula;Measures;Multimodal Imaging;Natural History;novel;Obesity;older patient;Optical Coherence Tomography;Other Genetics;Outcome;Pathogenesis;Pathologic;Patients;personalized approach;Photoreceptors;Pilot Projects;Play;prevent;Prevention strategy;preventive intervention;Process;progression risk;recruit;Registries;Research;Retina;Risk;Risk Factors;Role;Secondary Prevention;Support System;systemic inflammatory response;targeted treatment;Therapeutic Intervention;Thick;Thinness;Time;Vision;Visual

PROJECT_TITLE: Biomarkers of Systemic Inflammation in Intermediate Age-Related Macular Degeneration

STUDY_SECTION: DPVS

STUDY_SECTION_NAME: Diseases and Pathophysiology of the Visual System Study Section[DPVS]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Autoimmune Disease;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Eye Disease and Disorders of Vision

ORG_CITY: AMHERST

ORG_DEPT: DENTISTRY

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

PHR: Project Narrative The proposed project has important implications for public health, as it will address a key mediator of immune dysfunction in Sjögren’s syndrome. We expect this study to result in identification of novel disease mechanisms of immune cell activation that can be targeted to improve the treatment of Sjögren’s syndrome, leading to improved oral and systemic health for individuals afflicted with this debilitating disease.

PI_NAMEs: PUNNANITINONT, ACHAMAPORN  (contact)

PROGRAM_OFFICER_NAME: FUQUA, CHANTEL FAYSAN

PROJECT_TERMS: Acceleration;Address;Adoptive Transfer;Affect;age related;Agonist;American;Animals;Antigen Presentation;Autoantibodies;Autoimmune Diseases;Autoimmunity;Automobile Driving;autoreactivity;B-Cell Activation;B-Lymphocyte Subsets;B-Lymphocytes;Biological Models;Biological Response Modifiers;Blood Cells;burden of illness;career;Cell Compartmentation;cell type;Cells;Characteristics;Chronic;curative treatments;cytokine;Data;Development;Diagnosis;Disease;Early Diagnosis;Endosomes;Environment;Etiology;Event;Exhibits;Exocrine Glands;experience;experimental study;Family member;Fellowship;Health;Human;Immune;immune activation;Immune system;Immune System Diseases;improved;In Vitro;in vivo;Individual;Inflammation;Inflammatory;innovation;insight;Interleukin-1 Receptors;Kidney;Knock-out;Laboratories;lacrimal;Ligands;Lung;Lupus;Mediating;meetings;Modeling;morphogens;mouse model;Mus;Myelogenous;novel;Oral;oral biology;palliate;palliative;Pathogenesis;Pathogenicity;Pathology;Pathway interactions;Patients;peripheral blood;polarized cell;Production;Proteins;Public Health;receptor;Recording of previous events;Reporting;Research;response;Rest;Role;Saliva;Salivary;Science;Seminal;Signal Transduction;Sjogren's Syndrome;skills;Sorting;Symptoms;systemic autoimmune disease;Systemic disease;T-Lymphocyte;targeted treatment;Testing;therapeutic development;Tissues;TLR7 gene;Toll-like receptors;Training;Training and Education;Universities;Writing

PROJECT_TITLE: Role of TLR7-mediated B cell activation in primary Sjogren’s syndrome

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Genetics;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: This proposal focuses on abnormal RNA decay pathways that may contribute to neuronal dysfunction and death in the neurodegenerative diseases amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). Work conducted during the previous funding period highlighted critical connections between the RNA binding protein TDP43 and RNA instability in these conditions; here, we will uncover the mechanism underlying TDP43’s effects on RNA decay, while simultaneously evaluating two promising genetic modifiers of neurodegeneration in ALS and FTLD.

PI_NAMEs: BARMADA, SAMI  (contact)

PROJECT_TERMS: Adenosine;Affect;ALS patients;Amyotrophic Lateral Sclerosis;Binding;Binding Proteins;C9ORF72;Categories;cell type;Cells;Cytoplasm;Data;Deposition;Disease;Equilibrium;Failure;Familial disease;Family;Frontotemporal Lobar Degenerations;frontotemporal lobar dementia amyotrophic lateral sclerosis;Funding;Genes;Genetic;Genetic Transcription;Goals;Health;Homeostasis;Human;Hypermethylation;Impairment;Individual;Induced pluripotent stem cell derived neurons;Interruption;Introns;knock-down;Lead;Maps;Mediating;Messenger RNA;Methylation;Microscopy;Modeling;Modification;mutant;Mutation;Nerve Degeneration;Neurodegenerative Disorders;neuron loss;Neuronal Dysfunction;neuronal survival;Neurons;neuroprotection;Nitrogen;novel;Nuclear Protein;Nuclear RNA;overexpression;particle;Pathogenesis;Pathologic;Pathology;Pathway interactions;Patients;Pattern;prevent;Process;Property;protein function;protein TDP-43;Proteins;Proteome;Quality Control;Reader;response;Ribosomal Proteins;RiboTag;RNA;RNA Binding;RNA chemical synthesis;RNA Decay;RNA Helicase;RNA Instability;RNA Splicing;RNA Stability;RNA-Binding Protein FUS;RNA-Binding Proteins;Sampling;single molecule;Spinal Cord;Survival Analysis;Testing;Therapeutic;therapeutically effective;Toxic effect;Transcript;Translations;Work

PROJECT_TITLE: RNA decay in amyotrophic lateral sclerosis and frontotemporal lobar degeneration

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


NIH_SPENDING_CATS: Genetics;Neurosciences;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: NARRATIVE Spinal cord injuries are incurable in mammals, but reversible in adult zebrafish. Our work will study the pro- regenerative glial cells that contribute to regeneration in zebrafish, and the pathways that distinguish regenerative cells in zebrafish from non-regenerative cells in mammals. These studies will guide approaches for manipulating the burdens to mammalian spinal cord repair.

PI_NAMEs: MOKALLED, MAYSSA H. (contact)

PROGRAM_OFFICER_NAME: BAMBRICK, LINDA LOUISE

PROJECT_TERMS: Adult;American;apolipoprotein E-4;Astrocytes;Automobile Driving;Cells;Cellular biology;Chronic;Cicatrix;CRISPR screen;Early identification;Environment;epithelial to mesenchymal transition;experimental study;extracellular;fascinate;Functional Regeneration;gain of function;Gene Expression;gene regulatory network;Genes;Genetic;Genetic Transcription;glial activation;Gliosis;Grant;Human;Impairment;in vivo;Injury;innovation;Intervention;loss of function;Macrophage;Macrophage Activation;Mammals;Maps;Microglia;Molecular;Motor;mutant;Natural regeneration;neural;neural repair;Neuroglia;Outcome;overexpression;Paralysed;Pathogenicity;Pathway interactions;peptidomimetics;progenitor;programs;Protein Isoforms;psychologic;Recovery;Recovery of Function;regeneration model;regenerative;Regenerative capacity;regenerative cell;Regenerative Medicine;Regenerative response;Rehabilitation therapy;Reporter;Resolution;response;response to injury;Role;Scientist;Sensory;Series;Spinal Cord;Spinal cord injury;spinal cord regeneration;spinal cord repair;Spinal Cord transection injury;Structure;teleost fish;Testing;Therapeutic;therapy development;Tissues;transcription factor;Transcription Repressor;transcriptomics;Work;Zebrafish

PROJECT_TITLE: Glial cell responses promote spinal cord repair in zebrafish

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


ORG_DEPT: ANESTHESIOLOGY

PHR: Project Narrative The studies proposed in this application will provide critical insights into the mechanisms of modulation of volt- age gating in voltage-dependent ion channels. These ion channels are involved in electrical excitability in brain, heart and muscles. Dysfunction of these channels cause variety of excitability disorders such as arrhythmias and epilepsies. Understanding the mechanism of action of these ion channels will lay the groundwork for de- velopment of new therapeutics.

PI_NAMEs: CHANDA, BARON  (contact)

PROGRAM_OFFICER_NAME: UMANAH, GEORGE KWABENA ESSIEN

PROJECT_TERMS: Address;Algorithmic Analysis;Architecture;Arrhythmia;Binding;Biological Models;Biophysical Process;Brain;Chemicals;Cyclic Nucleotides;Development;Disease;driving force;drug development;Elements;Epilepsy;Exhibits;Fluorometry;Functional disorder;Heart;High temperature of physical object;high throughput analysis;insight;Ion Channel;Ion Channel Gating;Length;Life;Ligand Binding;Ligands;Measures;member;Membrane;Modeling;Molecular;Molecular Probes;Muscle;mutant;new therapeutic target;novel strategies;novel therapeutics;Property;Protein Dynamics;Proteins;receptor;reconstruction;Regulation;response;Second Messenger Systems;Signal Transduction;simulation;single molecule;Spectrum Analysis;Stimulus;Structure;supercomputer;Temperature;Temperature Sense;Testing;Thermodynamics;tool;voltage;voltage clamp;waveguide

PROJECT_TITLE: Biophysical mechanisms of gating and modulation in voltage-gated ion channel superfamily


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

ORG_CITY: KNOXVILLE

ORG_NAME: UNIVERSITY OF TENNESSEE KNOXVILLE

ORG_STATE: TN

PHR: PROJECT NARRATIVE Membrane proteins are fundamental for the function of the cell. When membrane proteins malfunction, diseases such as cancer occur. We propose to develop a method that allows to study how membrane proteins work, and to design molecules that can be used to prevent errors in the activity of membrane protein.

PI_NAMEs: BARRERA, FRANCISCO NICOLAS (contact)

PROGRAM_OFFICER_NAME: NIE, ZHONGZHEN

PROJECT_TERMS: Acidity;Autoimmune Diseases;Binding;Cell Physiology;Data;design;Development;Disease;Generations;improved;Investigation;Knowledge;Ligand Binding;Ligands;Lipids;Malignant Neoplasms;Membrane;membrane activity;Membrane Proteins;Methods;Molecular;novel therapeutic intervention;Peptides;prevent;receptor;receptor function;single molecule;Stimulus;Thermodynamics;Tissues;Transmembrane Domain;Work

PROJECT_TITLE: Mechanisms of modulation of transmembrane interactions


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Genetics;Human Genome;Mental Health;Mental Illness;Neurosciences

ORG_CITY: IOWA CITY

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Project Narrative The regulation of specific genes critical to the storage of memories (“memory consolidation”) and changes in neuronal function (“plasticity”) vital for learning are controlled by a number of mechanisms that are not themselves regulated by genetics. We propose to determine the functional roles of such epigenetic processes in memory consolidation and plasticity, and to define the sets of genes that are activated, in individual cells, during memory consolidation. This research promises to provide information that will be critical to the development of novel therapeutics capable of alleviating the cognitive deficits underlying many psychiatric disorders.

PI_NAMEs: ABEL, EDWIN TED G. (contact)

PROGRAM_OFFICER_NAME: LEINWAND, SARAH GOLDBERG

PROJECT_TERMS: Acetyl Coenzyme A;Acetylation;Acylation;ATAC-seq;autism spectrum disorder;bioinformatics tool;Bipolar Disorder;brain tissue;Cell Nucleus;cell type;Cells;ChIP-seq;Chromatin;Coenzyme A;Cognitive deficits;combinatorial;Complex;Data;Defect;Development;DNA;Dorsal;Epigenetic Process;epigenetic regulation;Event;experimental study;frontier;Funding;Gene Activation;Gene Expression;Gene Expression Profile;Gene Expression Regulation;Gene Targeting;Genes;Genetic;Genetic Transcription;Goals;Hippocampus;Histone Acetylation;histone modification;Histones;Hour;Individual;insight;knock-down;Knowledge;Learning;Link;long term memory;Machine Learning;Mediating;Memory;memory consolidation;memory retrieval;Mental Depression;Mental disorders;Messenger RNA;Metabolic;Methods;MicroRNAs;Modeling;Modification;Molecular;Mus;Mutant Strains Mice;Neurons;Neurosciences;new therapeutic target;non-genetic;novel;novel therapeutics;Nuclear RNA;Pattern;pharmacologic;Positioning Attribute;Post-Traumatic Stress Disorders;posttranscriptional;Process;Proteins;Regulation;Research;Ribonucleases;RNA;Role;Schizophrenia;Seminal;single nucleus RNA-sequencing;Sorting;Source;Statistical Methods;Synapses;Synaptic plasticity;System;Techniques;Technology;Time;Tissues;transcriptome sequencing;transcriptomics;Translational Derepression;Translational Regulation;Translational Repression;Translations;Untranslated RNA;Up-Regulation;Work

PROJECT_TITLE: Epigenetic Mechanisms of Memory Storage

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE We aim to develop a hydrogen deuterium exchange-mass spectrometry approach to examine the assembly and disassembly of SNARE proteins reconstituted in lipid nanodiscs in vitro and engineer a fluorescent sensor to study how the SNARE cycle is spatiotemporally linked to vesicle exocytosis in live cells. Achievement of these goals will provide a new means to answer questions related to membrane trafficking and SNARE pathology that are prevented from being addressed due to shortcomings in current technology. This work has the potential to help study the neuronal and metabolic diseases that arise from SNARE mutations.

PI_NAMEs: DALLO, SARAH ROSE (contact)

PROGRAM_OFFICER_NAME: STAMM, JOYCE CHIN-CHIN NG

PROJECT_TERMS: Achievement;Address;alpha-SNAP;Area;Biological Assay;Biology;biophysical analysis;Cell Communication;Cells;Color;Complex;conformational conversion;Coupled;Coupling;design;Deuterium;Disease;Engineering;Event;Exocytosis;experimental study;Fluorescence;genetic regulatory protein;Goals;Green Fluorescent Proteins;Health;Human;Hydrogen;improved;In Vitro;in vivo;Individual;insight;Lead;Link;Lipids;live cell imaging;Maps;Mass Spectrum Analysis;Mediating;Membrane;Membrane Fusion;Membrane Proteins;Metabolic Diseases;Molecular;Molecular Conformation;Monitor;Mutation;N-ethylmaleimide-sensitive protein;nanodisk;Neurons;neurotransmitter release;novel;novel strategies;Pathology;Pathway interactions;Performance;Physiologic Monitoring;Physiological;Physiological Processes;Positioning Attribute;prevent;Process;protein reconstitution;Proteins;receptor;reconstitution;Recycling;Regulation;Reporting;Resolution;Role;sensor;SNAP receptor;soluble NSF attachment protein;Solvents;spatiotemporal;success;syntaxin;Techniques;Technology;Testing;Time;tool;trafficking;Vesicle;vesicle-associated membrane protein;vesicular release;Work

PROJECT_TITLE: Probing SNARE assembly and disassembly in vitro and in live cells

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-D(21)L]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Methamphetamine;Neurosciences;Opioid Misuse and Addiction;Opioids;Prescription Drug Misuse;Sleep Research;Stimulant Use and Misuse;Substance Misuse

PHR: NARRATIVE Rapidly increasing public health harms of methamphetamine use have been observed among people who use opioids underscoring the need for information on mechanisms underlying motivations for use to inform treatment development. The goal of this project is to rigorously evaluate orexin system regulation of opioid and methamphetamine use and co-use using a behavioral economic demand framework. The proposed project will provide key insights into pharmacological and behavioral mechanisms underlying methamphetamine and opioid use and co-use to guide expeditious development of novel treatments.

PI_NAMEs: STRICKLAND, JUSTIN CHARLES (contact)

PROGRAM_OFFICER_NAME: MOLLICK, JESSICA ANN

PROJECT_TERMS: actigraphy;Address;antagonist;Behavior;behavior measurement;behavioral economics;Behavioral Mechanisms;Blinded;Clinical;Clinical Research;Complement;Consumption;cost;Data;Development;drug action;drug craving;Drug usage;Eating;Elasticity;Enrollment;Epidemic;epidemiologic data;Epidemiology;Evaluation;FDA approved;Goals;Health;heroin use;Human;hypocretin;Individual Differences;insight;Laboratories;Laboratory Study;Link;Literature;Measures;men;Methamphetamine;methamphetamine use;Methods;motivated behavior;Motivation;novel;Opioid;opioid use;opioid use disorder;opioid user;Oral;Oral Administration;Overdose;Oxycodone;Participant;Personality;Persons;Pharmaceutical Preparations;pharmacologic;Pharmacotherapy;Placebos;pre-clinical;pre-clinical research;preclinical study;Price;Procedures;Public Health;Randomized;receptor;Regulation;Reporting;response;Risk Reduction;secondary analysis;Signal Transduction;Sleep;sleep behavior;Sleep disturbances;sleep regulation;Sleeplessness;Stimulant;stimulant use;System;Testing;therapy development;treatment trial;trend;Twin Multiple Birth;United States;Water consumption;Woman;Work;Wrist

PROJECT_TITLE: Influence of Orexin Antagonism on Opioid and Methamphetamine Demand

STUDY_SECTION: ARM

STUDY_SECTION_NAME: Addiction Risks and Mechanisms Study Section[ARM]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Infectious Diseases;Rare Diseases;Vector-Borne Diseases

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: NARRATIVE  Inflammasomes can distinguish between pathogens and non-pathogenic microbes via the detection of ‘patterns-specific activities.’ This proposal uses an evolution-guided framework to translate novel interactions between the human NAIP/NLRC4 and NLRP1 inflammasomes with the human pathogens Shigella flexneri and Dengue virus, respectively, to generate new, rationally-designed models of human infectious disease and immunity.

PI_NAMEs: MITCHELL, PATRICK S (contact)

PROGRAM_OFFICER_NAME: GAUTAM, RAJEEV

PROJECT_TERMS: Advanced Development;Antigen-Antibody Complex;arms race;Autoimmune Diseases;autoinflammatory diseases;CASP1 gene;Communicable Diseases;cross-species transmission;Dengue Infection;Dengue Virus;Detection;disease transmission;Enteral;enteric infection;Evolution;Exhibits;Genetic;Goals;gut inflammation;host-pathogen coevolution;Human;human model;human pathogen;Immunity;improved;Infection;Infectious Diseases Research;Inflammasome;Inflammatory;innovation;insight;Laboratory mice;Link;Microbe;Modeling;Molecular;mouse model;Mus;Nature;novel;pathogen;Pathogenesis;pathogenic bacteria;Pattern;Peptide Hydrolases;Predisposition;rational design;Recording of previous events;recruit;Recurrence;Refractory;response;Role;Shigella;Shigella flexneri;Shigella Infections;Signal Transduction;Stimulus;Stress;Translating;Translations;Virus Diseases;Vision

PROJECT_TITLE: Translation of evolution-guided insights for new models of human infectious disease


ORG_CITY: PONCE

ORG_DEPT: PHYSIOLOGY

ORG_NAME: PONCE SCHOOL OF MEDICINE

ORG_STATE: PR

PHR: The enhanced training provided by the G-RISE at Ponce Health Sciences University will increase the number of Hispanic Americans doing biomedical research and encourage the growth of biomedical research in Puerto Rico. By contributing to a more culturally diverse research workforce, the program will foster biomedical research of minority health disparities.

PI_NAMEs: APPLEYARD, CAROLINE B (contact)

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TERMS: Health Sciences;Universities


NIH_SPENDING_CATS: Neurosciences

ORG_CITY: PHILADELPHIA

ORG_NAME: THOMAS JEFFERSON UNIVERSITY

ORG_STATE: PA

PHR: The goal of the proposed research is to understand the mechanism regulating microtubule-based transport into and out of axonal branches that are critical to synaptic development and function. Following our recent study of branch development and transport regulation at branch junctions, we will use molecular, imaging, and optogenetic approaches to investigate how transport is selectively routed for functional needs of the branch, especially via novel interactions between microtubule-associated proteins and motor proteins. Results from the proposed study will not only establish a general feature of axonal transport, but also shed lights on the mechanisms critical to synaptic function and dysfunction.

PI_NAMEs: MA, LE  (contact)

PROGRAM_OFFICER_NAME: TYLER, WILLIAM A

PROJECT_TERMS: Adult;Afferent Neurons;anterograde transport;Axon;Axonal Transport;Behavior;Binding;Biological;cell age;cell type;Cells;Color;Cytoskeleton;Darkness;Data;Dendrites;Development;Disease;Dissociation;Distal;Dynein ATPase;Embryo;Embryonic Development;Epilepsy;experimental study;Functional disorder;Functional Regeneration;Genetic;Goals;Growth;Health;Human;Image;Impairment;In Situ;Injury;insight;interest;Kinesin;Knowledge;Light;Link;Location;Lysosomes;MAP1 Microtubule-Associated Protein;Mediating;Membrane;Microtubule-Associated Proteins;Microtubules;Mission;Mitochondria;Modeling;Molecular;Morphogenesis;Motor;nerve injury;Nervous System;Nervous System Disorder;Nervous System Physiology;Neurodegenerative Disorders;Neurons;novel;optogenetics;Oranges;preference;Presynaptic Terminals;Proteins;Recovery of Function;recruit;Regulation;Research;response;RNA;Role;Route;Shapes;Signal Transduction;Slice;Specificity;Speed;Spinal Ganglia;Synapses;synaptic function;Testing;tool;trafficking;United States National Institutes of Health

PROJECT_TITLE: Regulation of Axonal Transport At Branch Junctions

STUDY_SECTION: SYN

STUDY_SECTION_NAME: Synapses, Cytoskeleton and Trafficking Study Section[SYN]


ORG_CITY: LITTLE ROCK

ORG_NAME: UNIV OF ARKANSAS FOR MED SCIS

ORG_STATE: AR

PHR: PROJECT NARRATIVE  The Center for Microbial Pathogenesis and Host Inflammatory Responses (CMPHIR: P20-GM103625) was established at the University of Arkansas for Medical Sciences (UAMS) in 2012. The underlying scientific theme is that addressing existing and emerging problems in infectious disease in a clinically relevant fashion will require an understanding of both the pathogens themselves and the manner in which they impact the host immunological and inflammatory response. This theme is based on the premise that understanding the complex interplay between diverse pathogens and their common human host is a necessary prerequisite to maximizing opportunities to manipulate one or both sides of this equation in favor of the desired prophylactic and/or therapeutic outcome.

PI_NAMEs: SMELTZER, MARK S (contact)

PROGRAM_OFFICER_NAME: CUPIT, PAULINE

PROJECT_TERMS: Address;adverse outcome;Arkansas;career;career development;Centers of Research Excellence;Clinical;clinically relevant;Communicable Diseases;Complex;Core Facility;Development;Elements;Ensure;Environment;Equation;Foundations;Funding;Goals;Grant;Growth;Human;Immune response;Infection;Inflammatory Response;Infrastructure;interest;Medical;member;Mentors;microbial;National Institute of General Medical Sciences;pathogen;Pathogenesis;pathogenic microbe;Phase;Positioning Attribute;programs;prophylactic;recruit;Research;Research Infrastructure;Research Personnel;Resources;Science;Scientist;Side;success;therapy outcome;Universities;Virulence Factors


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding

PROJECT_TERMS: Address;Advisory Committees;Applications Grants;Area;Arkansas;Basic Science;career;Center for Translational Science Activities;Centers of Research Excellence;Clinical Sciences;clinically relevant;college;Communicable Diseases;Communication;Development;Development Plans;Disease;Doctor of Philosophy;Ensure;Environment;experience;Extramural Activities;Fostering;Funding;Goals;Grant;Growth;Heart;Immune response;Individual;Inflammatory;Inflammatory Response;Infrastructure;innovation;Institution;Interdisciplinary Study;interest;Laboratories;Lead;Leadership;Letters;Medical;Medicine;meetings;Mentors;microbial;Pathogenesis;Phase;Positioning Attribute;Process;Productivity;Program Development;Program Research Project Grants;programs;recruit;Research;Research Infrastructure;Research Personnel;Resources;Science;Scientist;Seasons;Strategic Planning;Structure;success;Teacher Professional Development;Textiles;Universities;Virulence Factors;Work

PROJECT_TITLE: Core A: Administrative and Scientific Development Core


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics;Neurosciences

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: Narrative In a mature mammalian retina, more than forty distinct types of retinal ganglion cells (RGCs), the important components of retinal circuits and functions, have been described on the basis of their morphologies and functions. By learning how RGC subtypes are regulated by T-box transcription factors Tbr1 and Tbr2, we will obtain new information on the fundamental principles guiding retinal ganglion cell development and preventing them from dying under certain disease conditions, such as glaucoma and ischemic optic neuropathy. Obtaining such knowledge is the important first step to develop novel therapeutic strategy for retinal stem cell reprogramming and regeneration.

PI_NAMEs: MAO, CHAI-AN  (contact)

PROGRAM_OFFICER_NAME: WRIGHT, CHARLES BAKER

PROJECT_TERMS: Amacrine Cells;Anatomy;Applications Grants;autism spectrum disorder;Axon;Behavior;Brain;cell regeneration;Cell Reprogramming;cell type;Cells;Central Nervous System;Characteristics;circadian biology;conditional knockout;Coupling;design;Development;Disease;Electrophysiology (science);Funding;gain of function;Gap Junctions;Gene Expression;Genes;Genetic;Genetic Transcription;Genomics;Glaucoma;Goals;Image;Individual;Ischemic Optic Neuropathy;Knock-in;Knowledge;Label;Learning;Light;Maintenance;Maps;Mediating;melanopsin;migration;Molecular;molecular marker;Morphogenesis;Morphology;mouse model;mRNA sequencing;Mus;Neurons;novel;novel therapeutic intervention;orientation selectivity;Output;overexpression;Pattern;Play;Population;prevent;programs;Reagent;Reporter;Retina;Retinal Ganglion Cells;retinal neuron;retinal progenitor cell;Risk Factors;Role;Structure;System;Testing;tool;Tracer;transcription factor;transcription regulatory network;Vision;visual information

PROJECT_TITLE: Roles of T-box transcriptional regulators in the development of RGC subtypes

STUDY_SECTION: BVS

STUDY_SECTION_NAME: Biology of the Visual System Study Section[BVS]


NIH_SPENDING_CATS: Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Genetics

PI_NAMEs: BLEVINS, JON SCOTT (contact)

PROJECT_TERMS: Address;Antibody Formation;Applications Grants;Arkansas;Award;base;cellular imaging;Centers of Research Excellence;Cloning;college;Core Facility;cost;Data;Dedications;DNA;DNA biosynthesis;DNA sequencing;DNA Sequencing Facility;Doctor of Philosophy;Ensure;Equation;Equipment;equipment acquisition;Fee-for-Service Plans;Fees;Flow Cytometry;Funding;Gel;Genes;genome-wide;Genomic Library;Genomics;Goals;Growth;Human Resources;Immunology;Inflammatory;Inflammatory Response;Institution;instrument;instrumentation;Investments;Laboratory Personnel;Maintenance;Manuscripts;Medical;Medicine;Methods;microbial;Microbial Genome Sequencing;Microbiology;microscopic imaging;Modernization;Molecular Biology;next generation;next generation sequencing;operation;Opportunistic Infections;pathogen;Pathogenesis;Phase;Preparation;programs;protein expression;protein purification;Proteins;quantitative imaging;Recovery;Research;Research Infrastructure;Research Personnel;Resources;response;RNA;Sampling;Science;Scientist;Service delivery model;Services;Side;success;Supervision;Technology;Time;tool;Training;Universities;user-friendly;Validation;voucher;Western Blotting;Work

PROJECT_TITLE: Molecular Biology Core


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Hydrocephalus;Infectious Diseases;Neurosciences;Orphan Drug;Pediatric;Rare Diseases

ORG_CITY: OMAHA

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: PROJECT NARRATIVE Cerebrospinal fluid shunt infections are a frequent complication of the treatment of hydrocephalus and can lead to long term neurologic deficits in pediatric patients. In this proposal, we will study the role of complement in neurologic damage associated with cerebrospinal fluid shunt infection. These studies will provide valuable information on how complement creates neurologic damage during shunt infection, potentially leading to new therapies that will decrease the consequences of infection for patients and improve their developmental outcomes.

PI_NAMEs: SKAR, GWENN L (contact)

PROGRAM_OFFICER_NAME: REZAIZADEH, KAVON PAUL

PROJECT_TERMS: Address;Adjuvant;adverse outcome;Age;Alzheimer's Disease;Animal Model;animal tissue;Antibiotic Therapy;Astrocytes;Award;Bacteria;Bacterial Meningitis;Brain;brain tissue;career development;Catheters;Central Nervous System;Cerebral Edema;Cerebrospinal fluid shunts procedure;Child;Childhood;Chronic;Clinical;Clinical Medicine;Communicable Diseases;Complement;Complement 1q;Complement Activation;complement C3 precursor;Complement Inactivators;complement pathway;Complication;conditional knockout;Data;Development;Development Plans;Disease;Effector Cell;Etiology;experience;experimental study;Foundations;Future;Goals;Hemorrhage;high risk;Homeostasis;Human;Hydrocephalus;Immune;improved;Infection;Inflammatory;Intracranial Hypertension;Intrathecal Space;Kinetics;Knock-out;knockout animal;Knockout Mice;Knowledge;knowledge base;Lectin;LoxP-flanked allele;Macrophage;Mediating;Microglia;Molecular;mortality;mouse model;Multiple Sclerosis;Mus;Nerve Degeneration;Nervous System Disorder;Nervous System Trauma;Neurologic;Neurologic Deficit;neuron loss;Neurosurgeon;new therapeutic target;novel strategies;novel therapeutics;Outcome;pathogen;Pathologic;Pathology;Pathway interactions;Patient-Focused Outcomes;Patients;pediatric patients;Performance;Physicians;premature;Procedures;response;retinogeniculate;Risk;Risk Factors;Role;Schools;Scientist;Seizures;Shunt Device;Source;Specialist;Staphylococcus epidermidis;Stroke;synaptic pruning;System;Technical Expertise;Testing;therapeutic target;Time;Training;Traumatic Brain Injury;United States

PROJECT_TITLE: The Role of Complement in Cerebrospinal Fluid Shunt Infections

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-1 Study Section[NST-1]


NIH_SPENDING_CATS: Digestive Diseases;Liver Disease

ORG_CITY: Los Angeles

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

ORG_STATE: CA

PHR: Project Narrative Acute liver failure is a major cause of morbidity and mortality. The elucidation of the mechanisms of liver cell death is extremely important in developing new approaches to preventing and treating liver injury. The current work focuses on JNK, a pivotal kinase in stress signaling, and the novel targets of JNK, which have been identified to influence glutathione synthesis, mitochondrial function and oxidative stress.

PI_NAMEs: KAPLOWITZ, NEIL  (contact)

PROGRAM_OFFICER_NAME: GARCIA, MARTHA

PROJECT_TERMS: acetaminophen-induced liver injury;acute hepatotoxicity;Acute Liver Failure;Address;Amino Acid Sequence;Apoptosis;Apoptosis Regulation Gene;Apoptotic;Autoimmune Hepatitis;Binding Sites;Body System;Calpain;Catalytic Domain;Cell Death;Cessation of life;Cysteine;Cytoplasm;Data;Dependence;Disease;Docking;drug induced liver injury;Enzymes;Family;GCLC gene;GCLM gene;Gene Expression;Glutathione;Health;Hepatocyte;Hepatotoxicity;Homo;Human;humanized mouse;Impairment;Individual;Investigation;knock-down;Knockout Mice;Ligase;Liver;liver injury;MAP Kinase Gene;MAPK8 gene;Mediating;Membrane Proteins;Mitochondria;mitochondrial dysfunction;Mitogen-Activated Protein Kinase Kinases;Modeling;Morbidity - disease rate;mortality;Mouse Strains;multicatalytic endopeptidase complex;Mus;Mutate;N-terminal;Necrosis;novel;novel strategies;Organ;Outer Mitochondrial Membrane;overexpression;Oxidative Stress;Oxygen;Phosphorylation;Phosphorylation Site;Phosphotransferases;Play;Predisposition;prevent;Production;Protein Isoforms;Proteins;Publishing;Reactive Oxygen Species;Recovery;Regulation;Resistance;response;restoration;Role;Seminal;Serine;Signal Transduction;Site;Site-Directed Mutagenesis;Stress;Testing;Toxic effect;transcription factor;Viral hepatitis;Wild Type Mouse;Work

PROJECT_TITLE: Targets of JNK in acute hepatotoxicity.

STUDY_SECTION: XNDA

STUDY_SECTION_NAME: Xenobiotic and Nutrient Disposition and Action Study Section[XNDA]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Infectious Diseases

PI_NAMEs: STUMHOFER, JASON S (contact)

PROJECT_TERMS: Address;Applications Grants;Award;base;cell preparation;Cells;Centers of Research Excellence;college;Computers and Advanced Instrumentation;Consultations;cost;Data;Data Analyses;Dedications;DNA sequencing;DNA Sequencing Facility;Doctor of Philosophy;Ensure;Equipment;Experimental Designs;Extramural Activities;Fee-for-Service Plans;Fees;Flow Cytometry;Funding;Goals;Grant;Hour;Human Resources;Immune response;Immunology;Infection;Infectious Diseases Research;Inflammatory Response;Institution;instrument;instrumentation;Investments;Manuscripts;Medicine;microbial;Microbiology;Modeling;Molecular Biology;operation;Opportunistic Infections;Pathogenesis;pathogenic microbe;Pathologic;Phase;Population;Process;programs;Recovery;Research;Research Infrastructure;Research Personnel;Resources;Scientific Advances and Accomplishments;Scientist;Service delivery model;Services;success;Supervision;Time;tissue preparation;Tissues;Training;voucher;Work

PROJECT_TITLE: Flow Cytometry Core


NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: CAMBRIDGE

ORG_NAME: WHITEHEAD INSTITUTE FOR BIOMEDICAL RES

ORG_STATE: MA

PHR: Program Director/Principal Investigator (Last, First, Middle): Bartel, David P. PROJECT NARRATIVE: The experiments of this proposal investigate how cells determine the amount of protein that is produced from each gene, with a focus on regulatory processes that influence the stability and utility of cellular messenger RNAs. Results from these experiments will provide resources and information needed to better understand the regulation of genes, including genes implicated in cancer, birth defects, and other human diseases. They will also provide insights helpful for those harnessing these gene-regulatory processes to study gene function, as well as those beginning to harness these processes to develop new therapies for treating human diseases.

PI_NAMEs: BARTEL, DAVID P (contact)

PROGRAM_OFFICER_NAME: CZAPLINSKI, KEVIN

PROJECT_TERMS: Area;Binding;Biochemical;Biochemical Pathway;Biological;Cells;Congenital Abnormality;Defect;Development;Disease;Embryo;experimental study;Fertility;G-Quartets;gene conservation;Gene Expression Regulation;gene function;Genes;Genetic Transcription;Growth;Human;human disease;improved;insight;Introns;Length;Malignant Neoplasms;Mediating;Messenger RNA;Methods;MicroRNAs;Molecular;mRNA Stability;mRNA Translation;novel therapeutics;Oocytes;Physiology;Play;Poly(A) Tail;polyadenylated messenger RNA;Post-Transcriptional Regulation;posttranscriptional;Principal Investigator;Process;programs;Proteins;Repression;Research Proposals;Resources;RNA;Role;Slice;Structure;Tail;Translational Repression;Translations;Untranslated RNA;Viral Cancer;Virus Diseases;Yeasts

PROJECT_TITLE: Post-transcriptional gene regulation


PI_NAMEs: MANZANO, MARK  (contact)

PROJECT_TERMS: Address;Applications Grants;base;biosafety level 3 facility;Cells;cellular imaging;Centers of Research Excellence;college;Communicable Diseases;Core Facility;cost;Data;Dedications;Development;DNA sequencing;Doctor of Philosophy;Electron Microscope;Elements;Ensure;Environment;Equipment;equipment acquisition;Fees;Flow Cytometry;Funding;Goals;Grant;Hour;Immune response;Infection;Inflammatory;Inflammatory Response;Institution;instrument;Laboratory Animal Medicine;Laboratory Personnel;live cell imaging;Maintenance;Manuscripts;Medicine;member;microbial;microbial host;Microscope;microscopic imaging;Modeling;Molecular Biology;operation;pathogen;Pathogenesis;pathogenic microbe;Phase;Phase Transition;Play;programs;prophylactic;Recovery;recruit;Research;Research Infrastructure;Research Personnel;Resources;Role;Scanning;success;Supervision;Technology;Therapeutic;Time;Training;voucher

PROJECT_TITLE: Microscopy and Cellular Imaging Core


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cachexia;Cancer;Genetics;Women's Health Research

ORG_CITY: MORGANTOWN

ORG_NAME: WEST VIRGINIA UNIVERSITY

ORG_STATE: WV

PHR: PROJECT NARRATIVE Fatigue is a condition frequently reported in a large number of patients with breast cancer, which can be attributed to tumor growth and can be exacerbated by chemotherapy and radiotherapy. There are currently no therapies targeting fatigue in this patient population. This application seeks to provide scientific knowledge of the mechanisms that contribute to fatigue in breast cancer patients as well as identify therapeutic options to treat this condition.

PI_NAMEs: PISTILLI, EMIDIO EDWARD (contact)

PROGRAM_OFFICER_NAME: LINDHURST, MARJORIE JEAN

PROJECT_TERMS: Address;Affect;Agonist;American Cancer Society;Animal Model;Attenuated;Bioenergetics;Body Weight decreased;Breast Cancer Cell;Breast Cancer cell line;Breast Cancer Model;Breast Cancer Patient;Cachexia;cancer diagnosis;Cancer Patient;Chemotherapy and/or radiation;Clinical;Clinical Research;clinically relevant;debilitating symptom;Defect;Diabetes Mellitus;Diagnosis;Disease;Down-Regulation;Electron Transport;experience;experimental study;Fatigue;FDA approved;Foundations;Functional disorder;Future;Gene Expression Profile;Genetic Transcription;Goals;Human;Impairment;improved;in vitro Model;innovation;Knowledge;Laboratories;Link;Malignant Breast Neoplasm;Mammary Neoplasms;Measures;Mediating;Metabolic;MicroRNAs;mimetics;Mission;Mitochondria;mitochondrial dysfunction;Modeling;Molecular;molecular subtypes;mortality;mouse model;Mus;Muscle;Muscle Contraction;Muscle Fatigue;Muscle Fibers;muscle form;Muscle Mitochondria;Muscular Atrophy;novel;oligomycin sensitivity-conferring protein;Operative Surgical Procedures;Outcome;patient population;Patients;Peroxisome Proliferator-Activated Receptors;Pharmaceutical Preparations;Phenotype;Physiological;Pioglitazone;Porifera;PPAR gamma;pre-clinical;Production;Quality of life;Regulation;Reporting;Research;response;Scientific Advances and Accomplishments;Signal Transduction;Skeletal Muscle;stem;targeted treatment;Testing;Therapeutic;therapeutic target;Time;transcription factor;treatment strategy;Treatment-Related Cancer;tumor growth;Tumor-Derived;Withholding Treatment;Work;Xenograft procedure

PROJECT_TITLE: Targeting Muscle Fatigability During Cachexia

STUDY_SECTION: SMEP

STUDY_SECTION_NAME: Skeletal Muscle and Exercise Physiology Study Section[SMEP]


NIH_SPENDING_CATS: Bioengineering;Brain Disorders;Fragile X Syndrome;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Rare Diseases

ORG_DEPT: ANATOMY/CELL BIOLOGY

PHR: The active sites of central synapses are several times smaller than can be resolved using conventional approaches. Thus, much of what we know about the complex and dynamic processes involved in synaptic transmission has been inferred from indirect electrophysiological and/or biochemical assays. Our innovative nanoscale resolution imaging technology can visualize, track, and quantify presynaptic processes with single- vesicle resolution. We propose a research program based on this technology that promises to close the gap in our knowledge of synaptic transmission, including the role such processes play in the pathophysiology of Fragile X syndrome.

PI_NAMEs: KLYACHKO, VITALY A (contact)

PROGRAM_OFFICER_NAME: LEE, CRYSTAL ANNE

PROJECT_TERMS: Actins;Active Sites;Address;Area;autism spectrum disorder;Behavior;Biochemical;Biological Assay;Cognition;Complex;Cytoskeleton;Defect;Diagnostic;Disease;dynamic system;Electrons;Electrophysiology (science);Fragile X Syndrome;Functional disorder;Funding;Goals;Heritability;Imaging technology;innovation;Intellectual functioning disability;Knowledge;Lead;light microscopy;Link;Motor;Movement;Myosin ATPase;nanoscale;Neurobiology;novel;Play;postsynaptic;presynaptic;Process;programs;Recycling;Research;Resolution;Role;spatiotemporal;Synapses;Synaptic Transmission;Synaptic Vesicles;synergism;Technology;Therapeutic;Time;Tissues;translational impact;Vesicle;Visualization;Work

PROJECT_TITLE: Mechanisms of Synaptic Transmission in Healthy and Disease States


PROJECT_TERMS: 2019-nCoV;Address;adverse outcome;Anti-Infective Agents;anti-microbial drug;Antibiotic Resistance;Area;Arkansas;Bacteria;biomaterial development;Centers of Research Excellence;Clinical;Collaborations;Communicable Diseases;comorbidity;Development;Diagnostic Procedure;Elements;Ensure;Equation;Foundations;Funding;Goals;Grant;Growth;Health;Howard Temin Award;Human;Immune response;Immunology;improved;Individual;Infection;Inflammatory Response;innovation;Institution;interest;Medical;Medicine;microbial;Microbiology;Mission;National Institute of General Medical Sciences;novel;Parasites;pathogen;Pathogenesis;pathogenic microbe;Pharmaceutical Preparations;Phase;Play;Predisposition;Prevalence;programs;Property;prophylactic;Publications;recruit;recruitment science;Research;Research Infrastructure;Research Personnel;Research Support;resistant strain;response;Science;Scientist;Side;success;Therapeutic;Therapeutic Intervention;Universities;vaccine development;Variant;Virus

PROJECT_TITLE: Pilot Grant Program


NIH_SPENDING_CATS: Physical Rehabilitation;Rehabilitation

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE The main goal of this training program is to continue to develop highly competitive junior scientists into future leaders in rehabilitation research. This goal will be met by taking advantage of a rich academic environment that offers numerous resources and a complementary and collaborative team of basic and clinical research mentors committed to training and career development. The program will continue to teach both predoctoral and postdoctoral trainees how to conduct, and the importance of, integrative research that spans from understanding disease at the cellular level to improving clinical rehabilitation practices.

PI_NAMEs: BUFORD, THOMAS W;RIMMER, JAMES HOWARD;THALACKER-MERCER, ANNA E. (contact)

PROGRAM_OFFICER_NAME: NITKIN, RALPH M

PROJECT_TERMS: Physical Medicine;Training

PROJECT_TITLE: Interdisciplinary Training in Pathobiology and Rehabilitation Medicine.


NIH_SPENDING_CATS: Clinical Research;Eye Disease and Disorders of Vision;Genetics;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: The proposed research is relevant to public health because retinal detachment due to fibrotic  membrane contraction leads to vision loss in millions of people worldwide every year and  understanding the mechanisms responsible for membrane contraction may lead to the development of  therapies to prevent future vision loss. Thus, this proposal is relevant to the part of NIH’s  mission that pertains to fostering fundamental creative discoveries and innovative research  strategies as a basis for ultimately protecting health.

PI_NAMEs: BLENKINSOP, TIMOTHY A. (contact)

PROGRAM_OFFICER_NAME: SHEN, GRACE L

PROJECT_TERMS: Adult;Affect;Age related macular degeneration;Amendment;Animal Model;Blindness;bone;Cartilage;Cell Culture Techniques;cell transformation;cell type;Cells;Contracts;Creativeness;Data;design;disabled;Disease;Disease Progression;Elements;Endothelial Cells;Epigenetic Process;Epiretinal Membrane;experimental study;Eye diseases;Fatty acid glycerol esters;Fostering;Functional disorder;Future;Gene Expression;Genes;Genetic Transcription;Goals;Grant;Growth;Health protection;In Vitro;in vitro Model;in vivo Model;innovation;insight;Knowledge;Macrophage;macula;MADH3 gene;Mediating;Membrane;membrane model;Mesenchymal;Methods;Mission;Modeling;Molecular Biology;Muller's cell;Muscle;Muscle Cells;Muscle Contraction;Myofibroblast;Neuroglia;novel;novel strategies;novel therapeutic intervention;Outcome;p38 Mitogen Activated Protein Kinase;Patients;Pericytes;Persons;Phenotype;Physiology;Population;preservation;prevent;Prevention;proliferative diabetic retinopathy;Proliferative Vitreoretinopathy;Proto-Oncogene Proteins c-akt;Protocols documentation;Public Health;Research;Research Proposals;response to injury;Retina;Retinal Detachment;Retinal Diseases;Retinal Hemorrhage;Retinal Perforations;Retinitis Pigmentosa;RNA;Role;Severities;Signal Pathway;Signal Transduction;stemness;Structure of retinal pigment epithelium;Techniques;Testing;therapy development;Tissue membrane;TNF gene;transcription factor;transcriptome;transcriptome sequencing;Transforming Growth Factor beta;United States National Institutes of Health;Vision;whole genome;Work

PROJECT_TITLE: Reversing Contractility in Epiretinal Membranes


NIH_SPENDING_CATS: Back Pain;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Emergency Care;Health Services;Pain Research

ORG_DEPT: OTHER HEALTH PROFESSIONS

PHR: Project Narrative Non-specific low back pain is a highly prevalent and costly medical condition often characterized by recurrent, fluctuating or persistent pain and limitations in function over time. In this project we will work to understand the role of impairments in spine movement on the course of recovery of pain and functional limitations after a person experiences acute low back. We also will conduct a study treating the impairments during pain-provoking functional activities in people with acute low back pain seeking care in an emergency department setting.

PI_NAMEs: VANDILLEN, LINDA R (contact)

PROGRAM_OFFICER_NAME: MARDEN, SUSAN F

PROJECT_TERMS: Accident and Emergency department;Acute;Age;Back;Behavior;care seeking;Characteristics;Chronic;Chronic low back pain;Clinical;clinical examination;comorbidity;cost;Data;design;Emergency department visit;Evaluation;Exercise;experience;flexibility;Goals;Health Care Costs;Image;Impairment;improved;Individual;innovation;interest;Learning;Low Back Pain;Measures;Medical Care Costs;motor impairment;Motor Skills;Movement;novel;observational cohort study;Outcome;Pain;Pain intensity;Patient Self-Report;Patients;Persistent pain;Persons;Phase;Prevalence;prognostic value;prospective;psychosocial;Randomized;Recording of previous events;Recovery;Recurrence;remediation;Research;Role;Sampling;skills training;Spinal;Surveys;Testing;Time;Training;treatment as usual;Vertebral column;Work

PROJECT_TITLE: Significance of Spinal Movement Impairments in Acute Low Back Pain

STUDY_SECTION: MRS

STUDY_SECTION_NAME: Musculoskeletal Rehabilitation Sciences Study Section[MRS]


ED_INST_TYPE: GRADUATE SCHOOLS

ORG_DEPT: BIOLOGY

ORG_NAME: COLUMBIA UNIV NEW YORK MORNINGSIDE

PHR: Project Narrative Comparative genomics and genetic engineering in model organisms are powerful tools that can be used to understand the biology underlying human traits, diversity and disease. We will study how essential proteins can evolve given the constraints imposed by the often multifaceted functions they perform, including for example, the important drug-target Na+,K+-ATPase, which has repeatedly evolved insensitivity to steroid inhibitors across diverse animals. Our work will yield insights into how new proteins associated with neurological and physiological disorders in humans, like Na+,K+-ATPase, can evolve new functions.

PI_NAMEs: ANDOLFATTO, PETER  (contact)

PROGRAM_OFFICER_NAME: ADKINS, RONALD

PROJECT_TERMS: Address;Amino Acid Substitution;Amino Acids;Animals;ATP phosphohydrolase;Behavior;Biology;Cardiac Glycosides;Chromosome Mapping;comparative genomics;Cre lox recombination system;CRISPR/Cas technology;Data;Dependence;Development;Disease;Drosophila genus;Drosophila melanogaster Proteins;Drug Targeting;Eating;Engineering;Evolution;Exhibits;experience;Fertility;fitness;Gene Expression Profiling;Genes;Genetic;genetic analysis;genetic architecture;Genetic Determinism;Genetic Drift;Genetic Engineering;Genetic Epistasis;Genetic Variation;Genome;genome editing;Genome engineering;genome wide association study;Genomics;Glycosides;Homeostasis;Human;Human Biology;human disease;In Vitro;in vivo;Individual;inhibitor;innovation;Insecta;insight;K ATPase;Learning;Link;Maps;model organism;Modeling;Molecular;Molecular Genetics;Mutation;Natural Selections;Nature;Neurologic;novel;Organism;Outcome;pathogenic bacteria;pathogenic virus;permissiveness;Phenotype;Physiological;Plants;Population;Population Genetics;Process;Property;protein function;Proteins;Quantitative Trait Loci;Recurrence;Resistance;Role;Shapes;Site;Steroids;System;Technology;Time;tool;Toxic effect;Toxin;trait;Variant;Vertebrates;whole genome;Work

PROJECT_TITLE: Effects of genetic background on adaptive evolution

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-GGG-B(02)M]


NIH_SPENDING_CATS: Genetics;Kidney Disease

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative Damage to the kidney filtration barrier resulting in urinary protein loss accounts for approximately 80% of end stage kidney disease where nearly 700,000 patients in the United States require dialysis or kidney transplantation. Understanding the fundamental biology is a necessity as currently, there is a lack of therapeutic options. In this grant proposal, we plan to elucidate the underlying components required to maintain a normally functioning filtration barrier, so that potential novel treatments can be discovered in the near future.

PI_NAMEs: ISHIBE, SHUTA  (contact)

PROGRAM_OFFICER_NAME: NIHALANI, DEEPAK

PROJECT_TERMS: Actins;Address;Applications Grants;Area;Attenuated;Bioinformatics;Biology;Blood Vessels;Calcium;Calpain;calpain inhibitor;Cell Cycle;Cell Line;Cells;Chronic Kidney Failure;Clustered Regularly Interspaced Short Palindromic Repeats;Cytoskeleton;Data;Deterioration;Development;Dialysis procedure;Disease;disease model;Disease Progression;End stage renal failure;Event;experimental study;Filtration;Functional disorder;Future;Gene Expression Regulation;gene function;Generations;Genes;Genetic;genetic approach;glomerular filtration;Goals;Grant;Human;In Vitro;in vivo;inhibitor;Injury;Integrins;Kidney;Kidney Diseases;Kidney Failure;Kidney Transplantation;Knock-out;Knockout Mice;Libraries;Link;loss of function;Maintenance;Measures;Mediating;Microtubules;Mitotic;Modeling;Molecular;mouse model;Mus;Nephrotic Syndrome;new therapeutic target;novel;Pathogenesis;Pathway interactions;Patients;Peptide Hydrolases;pharmacologic;Phenotype;Play;podocyte;Positioning Attribute;postmitotic;Prevalence;prevent;profilin 1;protective pathway;Proteins;Proteinuria;Proteolysis;Public Health;Regulation;renal damage;Renal function;Renal glomerular disease;Renin-Angiotensin System;repaired;Research Personnel;Role;Secondary to;Talin;Technology;Testing;Therapeutic;transcriptome sequencing;United States;urinary;Urine

PROJECT_TITLE: Role of Calpains in Podocyte Biology

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-P(03)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Dementia;Depression;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research

ORG_DEPT: PSYCHOLOGY

ORG_NAME: HERBERT H. LEHMAN COLLEGE

PHR: The fastest growing segment of the American population is that 85 years of age and older; these are the people most at risk of developing Alzheimer’s disease: the prevalence of Alzheimer’s disease in this group, now 35%, is expected to approach 50% by the year 2050. Research in depression as a risk factor for dementia has concentrated on the younger-old (mean age 74) rather than the oldest-old (80 years and greater); and it has rarely been examined in African Americans, for whom depression is more chronic and severe and the risk of dementia higher. This application will address a critical knowledge gap by investigating the association between depression and cognitive decline in the oldest-old African Americans, and by examining inflammation as a potential underlying mechanism.

PI_NAMEs: GUERRERO-BERROA, ELIZABETH  (contact)

PROGRAM_OFFICER_NAME: BERNAL, FEDERICO

PROJECT_TERMS: Affect;African American population;Age;Age Years;aging process;Alzheimer's Disease;American;Awareness;Biological;Biological Markers;Chronic;clinical practice;Cognition;cognitive function;Communities;cytokine;Data;Dementia;dementia risk;Depressed mood;depressive symptoms;Development;diabetic;Diagnosis;effective therapy;Enrollment;Equipment and supply inventories;Ethnic Population;Etiology;geriatric depression;Health Personnel;high risk;high risk population;Hispanic Populations;Impaired cognition;improved;Individual;Inflammation;Inflammatory;inflammatory marker;insight;Investigation;Knowledge;Measures;Mediator;Mental Depression;Minority Groups;neuropsychiatry;Neuropsychology;non-demented;normal aging;older adult;Persons;Population;Predisposition;Prevalence;prevent;Questionnaires;racial population;Research;Risk;Risk Factors;Role;Sampling;Serum;social stigma;Target Populations;targeted treatment;Testing;Time;Vulnerable Populations

PROJECT_TITLE: The role of depression in cognitive decline of oldest-old African Americans