ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PI_NAMEs: SHELINE, YVETTE I (contact)

PROJECT_TERMS: Acute;Address;Adult;Adverse effects;Algorithms;Amnesia;Anatomy;anti-depressive agents;Biological Markers;biomarker identification;Blood flow;Brain;Clinical;Clinical Research;Cognitive;cognitive benefits;Collaborations;Corpus striatum structure;Data;Disease remission;Disfluent;Dissociation;Dose;effective therapy;electric field;Electroconvulsive Therapy;Electroencephalography;Ensure;Executive Dysfunction;executive function;follow-up;Functional Magnetic Resonance Imaging;Hippocampus;Image;imaging study;Impaired cognition;improved;Individual;Intervention;Investigation;Knowledge;Magnetic Resonance Imaging;magnetic resonance imaging/electroencephalography;magnetic seizure therapy;Major Depressive Disorder;Measures;Medial;meter;Methodology;Methods;Modeling;multiple data types;National Institute of Mental Health;neuroimaging;Neuronal Plasticity;noninvasive brain stimulation;Outcome;Patient-Focused Outcomes;Patients;Phenotype;Prefrontal Cortex;Process;Prospective Studies;Protocols documentation;Public Health;Research Infrastructure;response;response biomarker;Safety;Sample Size;Seizures;side effect;Site;Spottings;Standardization;Structure;System;Testing;Thalamic structure;therapy outcome;Time;verbal;Weight

PROJECT_TITLE: 3/4-Deciphering Mechanisms of ECT Outcomes and Adverse Effects (DECODE)


ADMINISTERING_IC: CA

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Networking and Information Technology R&D (NITRD);Obesity;Prevention;Telehealth

ORG_CITY: OKLAHOMA CITY

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PI_NAMEs: BUSINELLE, MICHAEL S. (contact)

PROJECT_TERMS: Acceleration;adaptive intervention;Address;Advanced Development;Affective;Applications Grants;Behavioral;Bluetooth;Cancer Center;Cancer Center Support Grant;cancer prevention;cancer risk;cancer therapy;Carbon Monoxide;Catchment Area;Cellular Phone;Cognitive;community engaged research;community engagement;Community Outreach;cost;cost effective;Data;data streams;design;Development;Devices;Doctor of Philosophy;Ensure;Environment;experience;Funding;Goals;Grant;Growth;health disparity;Health Technology;Heavy Drinking;improved;Infrastructure;innovation;instrument;interest;Intervention;Investments;Knowledge;Leadership;Life;Link;Malignant Neoplasms;medication nonadherence;member;mHealth;mobile application;Mobile Health Application;Monitor;Obesity;Patient Self-Report;Patients;Peer Review;Pharmaceutical Preparations;Physiological;Positioning Attribute;prevent;Primary Prevention;quality assurance;quality of life for cancer survivors;Recommendation;Reporting;Research;Research Design;Research Personnel;research study;Resource Sharing;Resources;response;Risk Behaviors;Risk Factors;Science;Secondary Prevention;Services;skills;smartphone based assessment;Smoking;Technology;tertiary prevention;therapy development;Time;tool;Translations;Underserved Population;Unhealthy Diet;United States National Institutes of Health;wearable device;Work;working group

PROJECT_TITLE: Mobile Health Technology Shared Resource

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Bipolar Disorder;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Neurosciences;Pediatric;Prevention;Serious Mental Illness;Sleep Research

ORG_CITY: PITTSBURGH

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE Early recognition and treatment of mania spectrum symptoms is vital for a favorable prognosis. Psychomotor activation - increased activity or energy - is a central feature of the mania spectrum that can be quantified through objective measurement of locomotor activity. In a comprehensive laboratory assessment and naturalistic follow- up study, we propose to uncover the biobehavioral (circadian, reward) mechanisms driving locomotor activation and mania spectrum risk. Findings will improve early detection of mania symptoms, help identify those most vulnerable to worsening mania symptoms over time, and provide novel targets for interventions.

PI_NAMEs: SOEHNER, ADRIANE M. (contact)

PROGRAM_OFFICER_NAME: KING, ERIN MICHELE

PROJECT_TERMS: actigraphy;Adolescence;Adolescent;Adolescent and Young Adult;aged;Amygdaloid structure;Animals;Anterior;Automobile Driving;Behavior;behavior prediction;Behavioral;biobehavior;Biological;bipolar spectrum;circadian;Circadian Dysregulation;Circadian Rhythms;Clinical;Clinical assessments;clinical diagnosis;cost;Data;Detection;Diagnostic;diaries;Disease;Dorsal;Early Diagnosis;Early treatment;emerging adult;Ensure;Feeling suicidal;follow-up;Follow-Up Studies;Functional Magnetic Resonance Imaging;Future;High-dimensional Modeling;Human;Hypersensitivity;hypomania;Impairment;improved;indexing;Individual;Intervention;Joints;Laboratories;Light;Manic;Measurable;Measurement;Measures;Mediating;Melatonin;Mental Depression;Modeling;Monitor;Moods;Motivation;Motor;Motor Activity;motor behavior;Neurobiology;neuroregulation;Nonpharmacologic Therapy;novel;novel strategies;Online Systems;Onset of illness;Outcome;Participant;Patients;Pattern;Persons;Phase;Photoreceptors;Population;predictive modeling;prevent;Prevention;Production;Prognosis;prospective;prospective test;Protocols documentation;Recording of previous events;recruit;Research;response;reward expectancy;Rewards;Risk;Risk Marker;Sampling;Severities;Signal Transduction;Sleep;Specificity;substance use;Symptoms;System;Testing;Time;Ventral Striatum;Wrist

PROJECT_TITLE: Locomotor Activation and Mania Spectrum Risk: Circadian and Reward Mechanisms

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Assistive Technology;Behavioral and Social Science;Bioengineering;Clinical Research;Physical Rehabilitation;Rehabilitation

ORG_CITY: Aurora

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE  Osseointegrated prostheses are a novel alternative to a socket prosthesis that directly mount the prosthesis to the residual limb femur via a bone anchored implant, which allows the amputated limb to be loaded in a more normative fashion. Early evidence is highly promising regarding the improvement in function and quality of life after osseointegration; however mechanical failure due to implant loosening or periprosthetic fracture caused by pathologic loading at the bone-implant interface exists in a small subset of this population, yet the mechanistic understanding as to why remains poorly understood. The findings of this proposal will be fundamental in the understanding of bone-implant loading mechanics and failure mechanisms, which can be used to improve the efficacy of targeted post-surgical rehabilitation by normalizing loading following prosthesis osseointegration.

PI_NAMEs: GAFFNEY, BRECCA  (contact)

PROGRAM_OFFICER_NAME: NURMINSKAYA, MARIA

PROJECT_TERMS: Activities of Daily Living;Amputation;Awareness;biomechanical model;Body mass index;bone;bone health;Bone remodeling;career;Chronic;Clinical;clinical care;Clinical Data;Data;Data Set;design;Distal;efficacious intervention;Elements;Exercise;Failure;Femur;follow-up;Fracture;functional improvement;gait rehabilitation;Goals;Growth;habituation;healing;Image;Implant;improved;in vivo;independent ambulation;Intervention;Joints;kinematics;Knowledge;limb amputation;limb bone;Limb Prosthesis;Lower Extremity;Measures;mechanical load;Mechanics;Modality;Modeling;Motion;Movement;Muscle;Musculoskeletal;Musculoskeletal System;novel;osseointegrated implant;Osseointegration;Outcome;Pathologic;Pathology;patient subsets;Patient-Focused Outcomes;Patients;Pattern;Physiologic calcification;Population;Procedures;Prosthesis;prosthetic socket;Protocols documentation;Quality of life;Rehabilitation therapy;Research Design;residual limb;Residual state;Retrospective Studies;Risk;strength training;Stress;Training;transmission process;Validation;Walking;Weight-Bearing state;Work

PROJECT_TITLE: Dynamic Bone-Implant Loading in Osseointegrated Prostheses


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding

ORG_CITY: UNIVERSITY

ORG_NAME: UNIVERSITY OF MISSISSIPPI

ORG_STATE: MS

PI_NAMEs: BLOOMEKATZ, JOSHUA ELI (contact);ROSS, SAMIR A

PROJECT_TITLE: The role of glycosylation in cell-state transitions during development and disease


NIH_SPENDING_CATS: Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Genetics;Human Genome;Microbiome

PI_NAMEs: BOUDREAU, PAUL DAVIS (contact);ROSS, SAMIR A

PROJECT_TERMS: Agonist;Anabolism;Antigens;Bacteria;Biological Assay;Candidate Disease Gene;candidate identification;Centers of Research Excellence;Chemistry;clinically relevant;Complex;cytokine;design;Galactose;Gene Cluster;Genes;Genome;genome sequencing;genomic data;Glycosphingolipids;gut microbiome;host microbiome;Human;Immune signaling;Immune system;Immunologic Stimulation;Ions;knockout gene;Laboratories;Libraries;Link;lipidomics;Lipids;Macrophage;Maps;member;microbiome;Molecular;Monitor;monomer;nanopore;Nanotechnology;Natural Products;Neutral Glycosphingolipids;novel;Organism;Pathway interactions;Process;Production;receptor;Role;scale up;screening;serine palmitoyltransferase;Signal Transduction;Soil;Source;Speed;Sphingolipids;Structure;sugar;System;Tail;whole genome;Work

PROJECT_TITLE: Glycosphingolipids from the Soil Microbiome, Understanding Structure and Biosynthesis


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: COLUMBIA

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

ORG_STATE: MO

PHR: Copper is an essential nutrient that is vital for oxygen metabolism. Although low tissue concentrations of oxygen are a common physiological stress, the adaptive mechanisms of copper homeostasis are unknown. The proposed research will elucidate the mechanisms by which oxygen regulates copper homeostasis and test the therapeutic potential of oxygen depletion as a novel treatment for a genetic copper overload disorder.

PI_NAMEs: PETRIS, MICHAEL J. (contact)

PROGRAM_OFFICER_NAME: ROY, CINDY

PROJECT_TERMS: Address;Altitude;Anemia;Animal Model;Asthma;Attenuated;Cell Line;Cell Nucleus;Cells;Ceruloplasmin;Chronic Kidney Failure;Chronic Obstructive Pulmonary Disease;Clinical;clinical translation;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;Congestive Heart Failure;Copper;CRISPR-mediated transcriptional activation;CRISPR/Cas technology;Cultured Cells;Diabetes Mellitus;Disease;Diving;Electron Transport;Erythrocytes;Erythroid Progenitor Cells;Erythropoiesis;Exertion;gain of function;gain of function mutation;Gene Activation;Genes;Genetic;Genetic Transcription;genome-wide;Goals;Health;Hemoglobin;Hepatic;Hepatocyte;Hepatolenticular Degeneration;HIF1A gene;Homeostasis;Homologous Gene;Human;Hypoxia;innovation;Iron;iron metabolism;Knock-out;Liver;Liver diseases;Malignant Neoplasms;Mammals;Mediating;Messenger RNA;Metabolism;metal transporting protein 1;mimetics;Mitochondria;Modeling;Molecular;mouse model;Mus;Mutation;normoxia;novel;Nutrient;Oxidative Phosphorylation;Oxygen;Oxygen Consumption;oxygen transport;Pathology;Pharmaceutical Preparations;Physiological;Plasma;Play;Process;Production;Proteins;Regulation;Research;response;Role;Sleep Apnea Syndromes;Stress;success;Testing;therapeutic evaluation;tissue oxygenation;Tissues;transcription factor;translational potential;Treatment Efficacy;ubiquitin-protein ligase;VHL gene;VHL protein;Wilson disease protein

PROJECT_TITLE: Novel roles of copper in adaptive responses to hypoxia

STUDY_SECTION: NMHD

STUDY_SECTION_NAME: Nutrition and Metabolism in Health and Disease Study Section[NMHD]


NIH_SPENDING_CATS: Cancer

PI_NAMEs: VESELY, SARA KATHERINE (contact)

PROJECT_TERMS: Accounting;anti-cancer research;Area;Basic Science;Bioinformatics;Biometry;Biostatistical Methods;Cancer Center;Cancer Center Support Grant;Centers of Research Excellence;Charge;Cherokee Nation;Clinical Cancer Center;Clinical Investigator;Clinical Research;Clinical Sciences;Clinical Trials;Clinical Trials Design;community research;Complex;Conceptions;Consultations;cost efficient;Data;Data Analyses;Data Collection;data imputation;data integration;Databases;design;Development;Doctor of Philosophy;doctoral student;education research;Educational process of instructing;Enrollment;Ensure;Epidemiology;experimental study;Faculty;Funding;Future;Genetic;genetic analysis;Goals;Grant;Growth;innovation;investigator-initiated trial;Knowledge;Machine Learning;Malignant Neoplasms;Manuscripts;member;Mentors;Meta-Analysis;Methods;Monitor;multiple data sources;novel;Observational Study;Oklahoma;Outcome;Peer Review;Phase;Phase I Clinical Trials;phase I trial;phase II trial;Pilot Projects;pilot trial;Play;Postdoctoral Fellow;Preparation;primary endpoint;Productivity;programs;Protocols documentation;Random Allocation;randomized, clinical trials;recruit;Reporting;Reproducibility;Research;Research Activity;Research Design;Research Personnel;research to practice;Resource Sharing;Resources;Retrospective Studies;Review Committee;Role;Safety;Sample Size;Sampling;Scheme;Services;Site;Statistical Data Interpretation;Statistical Methods;student training;Students;Surveys;systematic review;Training and Education;Translating;translational cancer research;Translational Research;undergraduate student;United States National Institutes of Health;web page;Work;Writing

PROJECT_TITLE: Biostatistics and Research Design Shared Resource


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Sleep Research

PI_NAMEs: ROSS, SAMIR A;STEWART, JAMES ALFRED (contact)

PROJECT_TERMS: Advanced Glycosylation End Products;Animals;behavioral impairment;Centers of Research Excellence;Elderly;Financial Hardship;glycosylation;healthspan;Impaired cognition;Impairment;Individual;Ion Channel;life span;Molecular;molecular dynamics;Muscular Atrophy;receptor;Regulation;Sleep Deprivation;Sleep disturbances

PROJECT_TITLE: Elucidating Molecular Mechanisms of Gating Regulation and Subunit Modulation of N-glycosylation on Ion Channels by Using Molecular Dynamics Simulations


PI_NAMEs: LI, JING  (contact);ROSS, SAMIR A

PROJECT_TITLE: Role of AGE/RAGEsignaling as a driver of pathological aging in the brain


ORG_CITY: LITTLE ROCK

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIV OF ARKANSAS FOR MED SCIS

ORG_STATE: AR

PHR: PROJECT NARRATIVE  The Arkansas IDeA Network for Biomedical Research Excellence (INBRE) program allows investigators in Arkansas to be more competitive for federal research funding that leads to better medical diagnoses and the development of therapies for human diseases. Arkansas INBRE support for undergraduate student training in biomedical research contributes to the development of the next generation of U.S. biomedical scientists.

PI_NAMEs: CORNETT, LAWRENCE E (contact)

PROGRAM_OFFICER_NAME: FAUPEL-BADGER, JESSICA

PROJECT_TERMS: Achievement;Address;American;Area;Arkansas;Baptist Church;base;Bioinformatics;Biomedical Research;biomedical scientist;Biotechnology;career;career development;Collaborations;college;Communication;computerized tools;Data;Data Analyses;design;Development;Diagnosis;education resources;Educational workshop;Ensure;Extramural Activities;Faculty;Faculty Recruitment;Funding;Future;Goals;Graduate Degree;Growth;Health;Human;human disease;Human Resources;improved;Individual;Industry;Infrastructure;Institution;instrumentation;Interdisciplinary Study;Lead;Leadership;Medical;Mentors;multidisciplinary;next generation;novel therapeutic intervention;Oklahoma;outreach;Ozarks;Participant;Phase;Play;Positioning Attribute;Program Development;Program Research Project Grants;programs;Proteomics;Research;Research Activity;Research Infrastructure;Research Personnel;Research Support;Resources;Role;Science;Scientific Advances and Accomplishments;Scientist;Signal Transduction;social media;student participation;student training;Students;success;symposium;Technical Expertise;Techniques;Technology;Teleconferences;therapy development;Training;undergraduate research experience;undergraduate student;Underrepresented Populations;Underrepresented Students;United States National Institutes of Health;Universities;Work;X Inactivation

PROJECT_TITLE: Partnerships for Biomedical Research in Arkansas


ADMINISTERING_IC: TW

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: HIV/AIDS;Patient Safety

ORG_CITY: NAIROBI CITY

ORG_COUNTRY: KENYA

ORG_FIPS: KE

ORG_NAME: KENYA MEDICAL RESEARCH INSTITUTE (KEMRI)

PHR: Narrative The proposed program will establish the first blended Masters and Postgraduate Diploma training in bioethics in Kenya at 2 local universities. The program will also build capacity of both Kenya and Pakistan-based faculty to support these graduate-level training programs by offering focused trainings in bioethics pedagogy, mentoring, and scientific writing including grantsmanship and manuscript development. Rapid capacity building initiatives will involve training stakeholders from both countries in basic and emerging issues in research and public health ethics through workshops and certificate courses, with a focus on enhancing human subject protection, especially in resource-limited settings.

PI_NAMEs: BUKUSI, ELIZABETH ANNE (contact)

PROGRAM_OFFICER_NAME: SINA, BARBARA J

PROJECT_TERMS: Accreditation;Address;Administrator;Adopted;Applications Grants;Bioethics;burden of illness;Clinical Ethics;Clinical Research;Collaborations;Committee Members;Country;Course Content;COVID-19 pandemic;Development;Disease;Educational Curriculum;Educational process of instructing;Educational Status;Educational workshop;Emergency Situation;Ensure;Ethics;Face;Faculty;Funding;Grant;Health;Human;human subject;human subject protection;improved;Inequity;Institution;International;Intervention;Kenya;Learning;low and middle-income countries;Manuscripts;Medical Research;member;Mentors;Mentorship;Methodology;Monitor;novel;Output;Pakistan;pedagogy;Peer Review;Persons;Preparation;Program Development;programs;Protocols documentation;public health ethics;Publications;Research;Research Ethics;Research Ethics Committees;Research Institute;Research Methodology;Research Personnel;Resource-limited setting;Series;skills;Social Sciences;Teacher Professional Development;tool;Training;Training Programs;Training Support;trial design;Uncertainty;Universities;virtual;Work;Writing

PROJECT_TITLE: CBEC-KEMRI BIOETHICS TRAINING INITIATIVE


PROJECT_TERMS: Address;Administrator;Advisory Committees;Arkansas;Award;Biomedical Research;career development;Collaborations;college;Communication;Complex;Decision Making;Dedications;Development;Doctor of Philosophy;Effectiveness;Electronics;Ensure;Extramural Activities;Faculty;Feedback;forging;Fostering;Goals;Institution;Lead;Leadership;Longevity;Measures;Medical;meetings;member;Mentors;Minority-Serving Institution;Mission;multimodality;next generation;Participant;Policies;Principal Investigator;Productivity;Program Evaluation;Program Research Project Grants;programs;Publications;Recording of previous events;Research;Research Activity;Research Infrastructure;Research Personnel;Research Support;Research Training;Resource Allocation;Resource Sharing;Resources;Role;Science;Services;Students;success;support network;Technology;Training;Training Programs;undergraduate student;Underrepresented Minority;Underrepresented Populations;United States National Institutes of Health;Universities;Vision;Work;X Inactivation

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Bioengineering;Building Research Capacity at Institutions with Limited NIH Funding;Data Science;Networking and Information Technology R&D (NITRD)

PI_NAMEs: GLAZKO, GALINA V (contact)

PROJECT_TERMS: Address;Arkansas;Assistantship;Big Data;Bioinformatics;bioinformatics infrastructure;bioinformatics resource;Biological Sciences;biomedical informatics;Biomedical Research;career;Collaborations;collaborative approach;complex data;Computational Biology;computer infrastructure;Computer software;computerized data processing;computerized tools;Computing Methodologies;Data Analyses;Data Science;data science education;Development;Doctor of Philosophy;drug development;drug discovery;Education;Educational Curriculum;Educational Status;Educational workshop;Event;experience;Experimental Designs;Faculty;Fostering;Foundations;Funding;genome sciences;Goals;Grant;Infrastructure;innovation;Institution;Investigation;Joints;Manuscripts;Medical;Medicine;Modeling;next generation;outreach;Phase;Preparation;programs;Proteomics;Publications;recruit;Research;Research Personnel;Research Support;Resources;Scholarship;Science;Services;skills;Societies;Students;success;Support Groups;symposium;synergism;Technology;Training;training opportunity;Training Programs;Travel;undergraduate student;Universities;voucher;Work;Workforce Development

PROJECT_TITLE: Bioinformatics Core


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Lung;Neurosciences;Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Substance Misuse

ORG_CITY: CHICAGO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Repeated opioid use is a significant factor driving overdose deaths in the continued opioid epidemic plaguing the U.S. healthcare system. This research evaluates how repeated fentanyl use, such as opioid use disorder remodels, the control of breathing. We examine the role for and mechanisms related to behavioral-based remodeling after repeated opioid use.

PI_NAMEs: GARCIA, ALFREDO J (contact);OTERO, JOSE JAVIER

PROGRAM_OFFICER_NAME: LAPOSKY, AARON D

PROJECT_TERMS: Acute;Address;Analgesics;Association Learning;Automobile Driving;Behavioral;Blood gas;Brain Stem;Breathing;Cause of Death;Clinical;Collaborations;comorbidity;conditioning;Dependence;Drug usage;Electrophysiology (science);experience;Failure;Fentanyl;fentanyl use;Fiber;Foundations;Genetic;genetic approach;Healthcare Systems;Homeostasis;In Vitro;in vivo;Individual;Ischemia;Knowledge;Laboratories;learned behavior;Learning;Machine Learning;Metabolism;Modeling;Morbidity - disease rate;neural network;Neurobiology;neuropathology;neurophysiology;neuroregulation;noradrenergic;novel strategies;novel therapeutics;Opioid;opioid epidemic;opioid mortality;opioid overdose;opioid use;opioid use disorder;opioid user;Outcome;Overdose;overdose death;overdose prevention;Pattern;Persons;Pharmaceutical Preparations;Pharmacodynamics;pharmacologic;Phenotype;Photometry;Physicians;Physiological;Play;Population;Predisposition;Prevention strategy;Property;Reflex action;Reperfusion Therapy;Research;Research Personnel;respiratory;response;Risk;Role;Scientist;Stimulus;Substance Use Disorder;Synapses;synthetic opioid;Testing;transcriptomic profiling;United States;Ventilatory Depression;Whole Body Plethysmography;Work

PROJECT_TITLE: Mechanisms of repeated opioid use dependent remodeling in respiratory control

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


NIH_SPENDING_CATS: Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding

PI_NAMEs: TACKETT, ALAN  (contact)

PROJECT_TERMS: Administrative Supplement;Arkansas;Award;Awareness;Bioinformatics;Biomedical Research;Biometry;Biotechnology;Collaborations;Consultations;Core Facility;Data;Data Collection;design;Development;Doctor of Philosophy;Education;Educational workshop;Eligibility Determination;Ensure;experience;Experimental Designs;Faculty;Funding;Goals;Infrastructure;Institution;instrumentation;Investments;Leadership;Medical;Methodology;new technology;Oklahoma;operation;Peer Review;Phase;Program Development;programs;Proteomics;Research;Research Personnel;Research Project Grants;Research Support;Resources;Science;service utilization;Site;Students;success;Techniques;Technology;technology development;technology/technique;Training;Training and Education;undergraduate research;undergraduate student;Universities;voucher

PROJECT_TITLE: Research Technology Core


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: EAST LANSING

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: MICHIGAN STATE UNIVERSITY

ORG_STATE: MI

PHR: Project Narrative The proposed research project is relevant to human health because antibiotic resistance is a growing problem threatening long-term global health outcomes and enormous associated costs. Bacteriophage are rising as an attractive supplemental or alternative therapy to combat bacterial infections, and an understanding of how phage structures mediate entry into bacterial hosts through the use of specialized receptor proteins is expected to give rise to new or improved uses of therapeutic phages. Therefore, this proposal is directly relevant to the NIGMS mission of supporting basic research to increase our general understanding of key biological processes that ultimately will lay a foundation for disease treatment.

PI_NAMEs: PARENT, KRISTIN N (contact)

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TERMS: Alternative Therapies;Antibiotic Resistance;Bacterial Infections;Bacteriophages;Basic Science;Binding;Binding Proteins;Biochemistry;Biological Process;Biophysics;Cell surface;Cells;combat;Complex;cost;deletion library;Disease;Docking;Engineering;enteric pathogen;Escherichia coli;Foundations;Gene Deletion;Genetic;global health;Goals;Health;Human;improved;Individual;Infection;Infection Control;innovation;insight;Laboratories;Mediating;Membrane Proteins;Microbiological Techniques;Mission;National Institute of General Medical Sciences;novel therapeutics;Outcome;Productivity;protein structure;Proteins;receptor;Receptor Cell;Research;Research Personnel;Research Project Grants;Resources;Salmonella;Shigella;Structure;technological innovation;Therapeutic Uses;Virus;Work

PROJECT_TITLE: Bacteriophage interactions with enteric pathogens

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-S(55)R]


NIH_SPENDING_CATS: Bioengineering

ORG_CITY: Chicago

ORG_DEPT: CHEMISTRY

ORG_NAME: NORTHWESTERN UNIVERSITY

PHR: Project Narrative: Our broader vision is to uncover the code for translating a range of protein surface structural characteristics into protein surface interaction and functional properties. The Han lab will pursue such translation using molecular biological and biochemical tools, as well as state-of-the-art characterization tools that capture surface structural properties with higher information content, greater level of details and resolution, including the properties of the protein surface water layer, protein dynamics, and protein conformation.

PI_NAMEs: HAN, SONGI  (contact)

PROGRAM_OFFICER_NAME: BARNES, CHARLES ASHLEY

PROJECT_TERMS: 2,4-Dinitrophenol;Affinity;aggregation pathway;Binding;Binding Sites;biochemical tools;Biological;Characteristics;Chemistry;Code;design;Detection;Disease;Electron Spin Resonance Spectroscopy;globular protein;Goals;Hydration status;Integral Membrane Protein;Knowledge;Learning;Measurement;Membrane Proteins;Methods;Modeling;Modification;Molecular;Molecular Conformation;Molecular Machines;Mutation;Nature;novel strategies;Nuclear;Nuclear Magnetic Resonance;Phase;Physiologic pulse;Physiological;Point Mutation;Property;Protein Conformation;Protein Dynamics;Protein Engineering;protein structure;Proteins;Rationalization;Resolution;Site;solid state nuclear magnetic resonance;Solubility;Spectrum Analysis;Structure;Structure-Activity Relationship;Surface;tau Proteins;tool;Translating;Translations;Vision;Water

PROJECT_TITLE: MIRA: Uncover Design Rules for Interaction and Assembly of Nature’s Molecular Machines

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-B(55)R]


NIH_SPENDING_CATS: Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding

PI_NAMEs: WANG, FENG  (contact)

PROJECT_TERMS: Arkansas;Award;Awareness;Bachelor's Degree;base;bench to bedside;Biomedical Research;career;Career Choice;Child;Climacteric;Collaborations;college;commercialization;Critical Thinking;design;Discipline;Diverse Workforce;Education;Educational workshop;Electronic Mail;Entrepreneurship;Evaluation;experience;Exposure to;Faculty;Feedback;Funding;Goals;Graduate Enrollment;Health;Health Sciences;Healthcare;Home;Human;improved;Individual;Infrastructure;innovation;Institution;Laboratories;Lead;Learning;Link;Location;Manuscripts;Mentorship;Opiate Addiction;Oral;Outcome;outreach;Participant;posters;Poverty;programs;recruit;Research;Research Infrastructure;Research Personnel;Resources;Science;skills;student mentoring;student participation;Students;success;summer program;summer research;summer student;Surveys;symposium;Technology;Training;undergraduate research experience;undergraduate student;Underrepresented Populations;Underrepresented Students;Writing

PROJECT_TITLE: Outreach Core


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: PROVIDENCE

ORG_NAME: MIRIAM HOSPITAL

ORG_STATE: RI

PHR: PROJECT NARRATIVE The Providence/Boston CFAR (Prov/Bos CFAR) is a collaboration between Lifespan/Brown University and Boston University/Boston University Medical Center leveraging our complementary and synergistic strengths to build a multidisciplinary HIV research portfolio. Our CFAR is particularly focused on marginalized populations including men who have sex with men (MSM), people who use substances, justice-involved persons, women, gender minorities, and at-risk youth both domestically and globally. The resources of the CFAR have resulted in an increase in our HIV funding, increased hiring of new faculty engaged in HIV research, and support for early stage investigators to develop a career in HIV research.

PI_NAMEs: CU-UVIN, SUSAN  (contact)

PROGRAM_OFFICER_NAME: SCHOONMAKER, ANNALISE ROSA

PROJECT_TERMS: Academic Medical Centers;Acquired Immunodeficiency Syndrome;Address;Area;Arkansas;Award;base;Basic Science;Behavioral;Behavioral Sciences;Biometry;Boston;career;Clinical;Clinical Sciences;co-infection;Collaborations;Communication;Communities;community collaboration;community engaged research;community engagement;community organizations;comorbidity;Continuity of Patient Care;Development;Discipline;Education;Educational workshop;Ensure;Epidemic;equity, diversity, and inclusion;Faculty;Funding;Future;gender minority;Goals;Grant;Health;HIV;HIV/AIDS;Immunology;improved;Incidence;innovation;Institution;International;Intervention;Justice;Kenya;Knowledge;Laboratories;Leadership;Learning;Life Cycle Stages;life span;marginalized population;Massachusetts;Medical center;member;men who have sex with men;Mentors;Microbiology;Mississippi;multidisciplinary;New England;next generation;novel;Oral health;outreach;Performance;Persons;Philippines;programs;Public Health;Research;Research Personnel;Research Support;Resources;Rhode Island;Risk;Services;Site;social media;South Africa;Speed;Strategic Planning;substance use;summer internship;Tennessee;Translational Research;Uganda;Ukraine;Underrepresented Minority;United States;United States National Institutes of Health;Universities;virology;Woman;working group;Youth;Zambia

PROJECT_TITLE: Providence/Boston Center for AIDS Research (CFAR)


PI_NAMEs: WARE, JERRY  (contact)

PROJECT_TERMS: Advisory Committees;Arkansas;Biomedical Research;Biometry;career;career development;Collaborations;Communities;design;Development;educational atmosphere;Educational workshop;Evaluation;experience;Experimental Designs;Extramural Activities;Faculty;Faculty Recruitment;faculty support;Fostering;Funding;Funding Mechanisms;Funding Opportunities;Future;Goals;Grant;Growth;hands on research;Home;improved;Individual;Institution;instrumentation;interest;Investments;Laboratories;Lead;Manuscripts;meetings;Mentors;Mentorship;Modeling;Modernization;next generation;Outcome;Outcome Measure;Peer Review;Play;Positioning Attribute;Preparation;Process;Program Research Project Grants;programs;Publications;recruit;Reproducibility;Research;Research Activity;research and development;Research Infrastructure;Research Personnel;Research Project Grants;Research Support;Review Committee;sabbatical;Science;Secure;Site Visit;Statistical Data Interpretation;student participation;Students;Study Section;success;summer research;Teacher Professional Development;undergraduate research experience;undergraduate student;United States National Institutes of Health;Writing

PROJECT_TITLE: DRP Program


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Emerging Infectious Diseases;Genetics;HIV/AIDS;Hematology;Human Genome;Infectious Diseases;Lymphatic Research;Lymphoma;Rare Diseases

ORG_NAME: WISTAR INSTITUTE

PHR: Narrative: The long-term goal of this R01 is to further advance our knowledge of the AIDS-defining malignancies caused by Kaposi’s Sarcoma-Associated Herpesvirus (KSHV). Investigation of the mechanisms regulating KSHV latency, episome persistence and oncogenesis through a deeper understanding of KSHV LANA will provide novel viral-specific targets for therapeutic intervention in KSHV-associated cancers and related disorders.

PI_NAMEs: LIEBERMAN, PAUL M. (contact)

PROGRAM_OFFICER_NAME: READ-CONNOLE, ELIZABETH LEE

PROJECT_TERMS: 3-nitrotyrosine;Acquired Immunodeficiency Syndrome;Aftercare;AIDS-Related Lymphoma;Angiolymphoid hyperplasia;Architecture;B-Lymphocytes;Biological Assay;cell growth;Cell model;Cell Proliferation;Cell Survival;Cells;Chromatin;Chromosomes;chronic infection;cohesin;Complex;cytokine;Data;DAXX gene;Disease;DNA;DNA Binding;DNA biosynthesis;drug sensitivity;endothelial stem cell;Epigenetic Process;epigenetic regulation;epigenome;epigenomics;Episome;Frequencies;Gene Expression;Gene Expression Profile;Genetic Recombination;Genetic Transcription;Genome;genome integrity;Genome Stability;Goals;Herpesviridae;Herpesviridae Infections;Higher Order Chromatin Structure;Histone H3.3;histone modification;HIV/AIDS;Human;Human Herpesvirus 4;Human Herpesvirus 8;Immune Evasion;Immune System Diseases;Inflammatory;inhibitor;Investigation;Kaposi Sarcoma;Knowledge;latent gene expression;latent infection;Life Cycle Stages;Liquid substance;Lymphatic Endothelium;Lymphoma;Lymphoma cell;Lytic;Maintenance;Malignant Neoplasms;Mesenchymal Stem Cells;Metabolic;Metabolic Pathway;Metabolic stress;Mitochondria;mouse model;NOS2A gene;novel;Nuclear;Nuclear Antigens;Oxidative Phosphorylation;Pathogenesis;Pathway interactions;Phase;Pleural effusion disorder;Process;programs;Receptor Protein-Tyrosine Kinases;recombinase;Regulation;Role;Structure;Syndrome;targeted treatment;Terminal Repeat Sequences;Therapeutic Intervention;transcriptomics;tumor;Tumor Suppressor Proteins;tumorigenesis;Tyrosine;Viral;viral DNA;Viral Genome;virus episome maintenance

PROJECT_TITLE: Epigenomic Control of KSHV Latency

STUDY_SECTION: HCAC

STUDY_SECTION_NAME: HIV Coinfections and HIV Associated Cancers Study Section[HCAC]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Dental, Oral, and Craniofacial Disease;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Prevention;Substance Misuse

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Advisory Committees;AIDS prevention;Area;Award;Basic Science;Behavioral;Behavioral Sciences;Boston;career;Clinical;Clinical Sciences;Collaborations;Communication;Communities;community engaged research;community organizations;Community Outreach;community partners;comorbidity;Development;Education;Epidemic;equity, diversity, and inclusion;Evaluation;Facilities and Administrative Costs;Faculty;Fostering;Foundations;Funding;Future;gender minority;Goals;Growth;Health;HIV;HIV/AIDS;Incidence;Infrastructure;innovation;Institution;Interdisciplinary Study;interest;International;Justice;Leadership;life span;marginalized population;Massachusetts;Measures;Mediation;Medical center;member;men who have sex with men;Mentors;Mentorship;minority investigator;Mission;multidisciplinary;Oral health;organizational structure;Persons;Population;Productivity;programs;Publications;recruit;Research;Research Activity;Research Infrastructure;Research Personnel;Research Priority;Research Support;Rhode Island;Risk;Scientist;Services;Site;Structure;substance use;Training;Translational Research;Underrepresented Minority;United States National Institutes of Health;Universities;Vulnerable Populations;Woman;Work;working group;Youth

PROJECT_TITLE: Core A - Administrative Core


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Clinical Research;Dental, Oral, and Craniofacial Disease;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Prevention;Substance Misuse

PI_NAMEs: WILSON, IRA B (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Affect;Arkansas;Articulation;Attention;Award;Basic Science;behavioral and social science;Behavioral Research;Boston;career;Categories;Clinical;Clinical Research;co-infection;cohort;Collaborations;Communities;community engaged research;community engagement;comorbidity;Consultations;County;Creativeness;design;Development;Educational workshop;Epidemic;epidemic preparedness;Faculty;faculty support;Fostering;Funding;Funding Mechanisms;Future;gender minority;Goals;Grant;HIV;HIV/AIDS;Hour;Incidence;innovation;Institution;interdisciplinary approach;Interdisciplinary Study;International;Justice;Leadership;marginalized population;Massachusetts;meetings;men who have sex with men;Mentors;Mission;Mississippi;Modification;National Institute of General Medical Sciences;next generation;Persons;Population;Productivity;programs;Published Comment;Research;Research Design;Research Personnel;Resources;Rhode Island;Risk;Series;social;social science research;Strategic Planning;substance user;Suggestion;Tennessee;Training;Translational Research;United States National Institutes of Health;Universities;Woman;Work;working group;Writing;Youth

PROJECT_TITLE: Core B - Developmental Core


PI_NAMEs: HOGAN, JOSEPH W (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Applications Grants;Archives;Basic Science;Biometry;Biostatistical Methods;Biostatistics Core;Boston;Clinical Research;Collaborations;comorbidity;complex data;Computer software;Continuing Education;cost effective;Data;Data Analyses;Data Collection;data format;data management;Databases;design;Development;Educational workshop;Electronic Health Record;Ensure;Epidemic;Epidemiologic Methods;Epidemiology;Faculty;Feedback;Funding;Goals;Grant;HIV;Hospitals;Immunology;Infrastructure;innovation;International;Internships;Journals;Justice;Knowledge;life span;Manuscripts;meetings;member;men who have sex with men;Mentors;method development;Methodology;Methods;Mission;Molecular;Needs Assessment;novel;Peer Review;Persons;Play;Policies;Population;Postdoctoral Fellow;pre-doctoral;programs;Reproducibility;Research;Research Design;Research Methodology;Research Personnel;Resources;Risk;Role;Rotation;Sampling;Scientific Advances and Accomplishments;Scientist;Secure;Statistical Methods;Structure;substance use;Training;Translational Research;United States National Institutes of Health;Universities;Update;Vulnerable Populations;Woman;Writing;Youth

PROJECT_TITLE: Core G - Biostatistics Core


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Cancer;Dental, Oral, and Craniofacial Disease;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Prevention;Substance Misuse

PI_NAMEs: KANTOR, RAMI  (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;antiretroviral therapy;Area;Basic Science;Behavioral;Behavioral Research;Behavioral Sciences;Biological Assay;Boston;Clinical;Clinical Research;Clinical Sciences;Collaborations;Consultations;Dedications;design;Detection;Devices;Disease remission;Drug resistance;Education and Outreach;Environment;Epidemic;experience;Faculty;Feedback;Fostering;Funding;Goals;Grant;HIV;HIV Infections;HIV/AIDS;Immune System Diseases;Immunology;improved;Inflammation;Infrastructure;innovation;Institution;International;investigator training;Leadership;life span;Location;Medical center;Mentors;Mentorship;Minority Groups;Mission;Molecular;multidisciplinary;Needs Assessment;novel;Persons;Point of Care Technology;prevent;Prevention;Publications;Publishing;Reduce health disparities;Research;Research Personnel;Research Project Grants;Research Support;Research Training;Resource-limited setting;Resources;Role;Science;Scientist;Services;Surveys;synergism;Technical Expertise;Technology;Technology Transfer;Training;Training and Education;Translational Research;Translations;transmission process;United States National Institutes of Health;Universities;virology;Virus;Work

PROJECT_TITLE: Core H - Basic Science Core


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Dental, Oral, and Craniofacial Disease;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Prevention;Social Determinants of Health;Substance Misuse

PI_NAMEs: KAHLER, CHRISTOPHER W. (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Adherence;AIDS prevention;base;Basic Science;Behavior Therapy;Behavioral Sciences;Biological Markers;Biomedical Research;Boston;Caring;catalyst;Chronic Disease;Clinical;Clinical Sciences;Collaborations;Communities;comorbidity;Complex;Consumption;Continuity of Patient Care;Development;Disease Management;Disparity population;Ecological momentary assessment;Educational workshop;Ensure;Epidemic;Faculty;Fostering;Funding;Goals;Grant;Health;Heavy Drinking;HIV;HIV diagnosis;Immunologics;improved;Individual;injection drug use;innovation;Intervention;Interview;investigator training;Knowledge;Laboratories;Link;Manuals;Manuscripts;Mentors;Methods;Mission;Mobile Health Application;Morbidity - disease rate;mortality;multidisciplinary;Neurokinin A;Outcome;Persons;Pharmacotherapy;Population;Population Heterogeneity;Positioning Attribute;pre-exposure prophylaxis;Public Health;racism;Research;Research Personnel;Research Priority;Research Project Grants;Research Support;Resources;Risk Factors;Role;Services;Severities;social health determinants;social stigma;sound;stimulant use;Structure;substance use;syndemic;synergism;Testing;tool;Training;Translational Research;transmission process;Trauma;uptake;Violence;Viral;Viral Load result;Work

PROJECT_TITLE: Core K - Substance Use Research Core


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Biodefense and Related Countermeasures;Cancer;Clinical Research;Dental, Oral, and Craniofacial Disease;Drug Abuse (NIDA only);Emerging Infectious Diseases;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Mental Health;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases;Social Determinants of Health;Substance Misuse;Tuberculosis;Women's Health Research

PI_NAMEs: BROWN, LARRY K (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Adherence;Adolescence;Adolescent;Adolescent and Young Adult;Adult;African American;AIDS prevention;Area;Behavior;Behavioral;Behavioral Research;Behavioral Sciences;biobehavior;Biological;Biological Specimen Banks;Bisexual;Black race;Boston;care outcomes;Caring;Cellular Phone;Cervical Cancer Screening;cis-female;Cities;Clinical;Clinical Research;Clinical Sciences;Collaborations;Communicable Diseases;Communities;community organizations;community partners;comorbidity;Continuity of Patient Care;cost effective intervention;Cost effectiveness research;Counseling;Criminal Justice;culturally appropriate intervention;Data;Data Collection;data repository;Data Set;Deep South;Development;Diabetes Mellitus;Disease;Disparity;Drug resistance in tuberculosis;Drug user;Education Projects;Enrollment;Environment;Epidemic;Ethics;ethnic minority;Evaluation;Faculty;Fostering;Gays;Gender;Geography;Health;Health system;Hispanic;HIV;HIV Infections;HIV/AIDS;HIV/HCV;HIV/TB;Human Papilloma Virus-Related Malignant Neoplasm;human subject;implementation science;improved;improved outcome;Individual;Inequity;Infection;Information Systems;Injectable;innovation;interest;International;Intervention;Justice;Latino;Lesbian Gay Bisexual Transgender Queer;low and middle-income countries;Malnutrition;marginalization;medication compliance;men who have sex with men;Mental disorders;Mental Health;Methods;Mission;Morbidity - disease rate;Names;National Institute of Mental Health;Natural History;NIH Office of AIDS Research;novel;Pathogenesis;Patient Recruitments;Persons;Pharmaceutical Preparations;Population;Populations at Risk;Positioning Attribute;Postpartum Women;Poverty;pre-exposure prophylaxis;Pregnant Women;prevent;Prevention;preventive intervention;racial minority;recruit;Research;Research Personnel;Research Priority;Research Support;Research Training;Resource-limited setting;Resources;Risk Behaviors;Risk Reduction;Science;Services;sexual violence;Site;skills;substance use;success;syndemic;System;Technology;Testing;theories;tool;Training Programs;transgender women;Translational Research;Trauma;Tuberculosis;United States National Institutes of Health;Unsafe Sex;uptake;Vulnerable Populations;Woman;Work;working group;Youth

PROJECT_TITLE: Core L - Clinical & Behavioral Sciences Core


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Dental, Oral, and Craniofacial Disease;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Prevention;Sexually Transmitted Infections;Social Determinants of Health;Substance Misuse

PI_NAMEs: BECKWITH, CURT G (contact)

PROJECT_TERMS: acceptability and feasibility;Acquired Immunodeficiency Syndrome;Address;AIDS prevention;AIDS-Related Opportunistic Infections;Alcohol consumption;Alcohols;Basic Science;Behavioral Sciences;Boston;Buprenorphine;career development;Chronic;Clinical Research;Clinical Sciences;Collaborations;Communities;community engaged research;comorbidity;Complex;Dedications;Dental;Dental Care;Dental caries;Dental Clinics;Dental Epidemiology;Dental Schools;Development;Diagnosis;Diagnostic;Drug usage;Ensure;Epidemiology;Epithelium;experience;Fostering;Goals;Group Meetings;Hairy Leukoplakia;Health;high risk;high risk population;HIV;HIV Infections;Human immunodeficiency virus test;Human Papilloma Virus-Related Malignant Neoplasm;Immune;improved;Incidence;Infection;Inflammation;innovation;Interdisciplinary Study;International;Justice;malignant mouth neoplasm;Malignant Neoplasms;marginalized population;Medicine;meetings;member;Mission;Morbidity - disease rate;Mouth Diseases;Mucosal Immunity;Mucous Membrane;Natural History;opioid use;opioid use disorder;Oral;Oral candidiasis;Oral cavity;Oral health;oral HIV;oral HPV;oral HPV infection;oral microbiome;Oral mucous membrane structure;Oropharyngeal;Outcome;Pathogenesis;Periodontal Diseases;Persons;Population;Prevention;prevention service;Productivity;programs;recruit;Research;Research Activity;Research Personnel;Resource-limited setting;Risk;screening;Services;Smoke;Social Sciences;social stigma;Squamous cell carcinoma;stimulant use;substance use;Substance Use Disorder;Tobacco use;Translational Research;transmission process;United States National Institutes of Health;Universities;Vulnerable Populations;Woman;working group;Youth

PROJECT_TITLE: HIV & Oral Scientific Working Group


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative Biophysics is an interdisciplinary field of the biomedical sciences that aims to understand the mechanisms of human health and disease on a molecular scale using the tools of the physical and quantitative sciences. The Molecular and Cellular Biophysics Program (MCBP) at the University of North Carolina at Chapel Hill is an established and successful training program in biophysics that seeks funding to train a diverse cohort of students for this rapidly advancing and critical field. Program graduates will be equipped to pursue innovative career trajectories that drive biomedical research and education through the training and leadership skills they developed and honed in the MCBP.

PI_NAMEs: KUHLMAN, BRIAN A (contact);SLEP, KEVIN C

PROGRAM_OFFICER_NAME: STAMM, JOYCE CHIN-CHIN NG

PROJECT_TERMS: Biophysics;Grant;Molecular;Training

PROJECT_TITLE: Molecular and Cellular Biophysics Training Grant

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - B[TWD-B]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Complementary and Integrative Health;Congenital Structural Anomalies;Estrogen;HIV/AIDS;Infectious Diseases;Neurodegenerative;Neurosciences;Nutrition;Pediatric;Regenerative Medicine

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

ORG_STATE: SC

PHR: Project Narrative: Following the great success of combination antiretroviral therapy (cART), older individuals (>50 years of age) account for approximately 30–50% of HIV-1 seropositive individuals in high-resource countries; a prevalence that is expected to reach approximately 73% by 2030. Neurological complications of HIV infection are the big- gest challenge facing HIV researchers and there is a critical need to develop treatment approaches for HIV-1- associated neurocognitive disorders (HAND). We are in a unique position to critically test the efficacy of a regenerative “dendritic spine-targeted” therapeutic approach to alter the longitudinal trajectory of HAND (i.e., delay progression of neurocognitive impairment) by restoring synaptodendritic integrity via the NogoA- NgR3/PirB-RhoA signaling pathway.

PI_NAMEs: BOOZE, ROSEMARIE M;MACTUTUS, CHARLES F. (contact)

PROGRAM_OFFICER_NAME: MARIC, MAJA

PROJECT_TERMS: Address;Affect;Age Years;age-related disease;Aging;Agonist;Animals;antiretroviral therapy;Attention;Biological Factors;biological sex;biological systems;brain cell;Cell Culture Techniques;Cell Death;Clinical;Clinical Trials;Cognitive;Country;Cross-Sectional Studies;daidzein;Data;Dendritic Spines;dietary;Disease Progression;Dysmorphology;efficacious treatment;efficacy testing;equol;Estrogen Receptor 2;Estrogens;executive function;Exhibits;Experimental Designs;Female;Frequencies;Functional disorder;gray matter;Growth;gut microbiome;hippocampal pyramidal neuron;HIV;HIV Envelope Protein gp120;HIV Infections;HIV-1;HIV-associated neurocognitive disorder;Impairment;In Vitro;in vivo;Individual;Ingestion;innovation;longitudinal design;male;Medial;Memory;Methodology;Modeling;Molecular;Natural regeneration;Neurocognitive;Neurocognitive Deficit;neuroimaging;neuroinflammation;Neurologic;neuromechanism;Neuronal Injury;Neurons;neuropathology;neurorestoration;Neurotransmitters;Nucleus Accumbens;older adult;Older Population;Pathway interactions;Patients;Persons;pharmacologic;Positioning Attribute;postnatal;Prefrontal Cortex;Prevalence;Process;Proteins;Publications;Rat Transgene;Rattus;regenerative;regenerative approach;regenerative therapy;Research Design;Research Personnel;Resources;restoration;Role;seropositive;Severities;sex;Signal Pathway;soy protein isolate;Specific qualifier value;success;Synapses;synaptic function;System;targeted treatment;Testing;Therapeutic Effect;therapeutic target;Time;Transgenic Mice;Treatment Efficacy;treatment optimization;Vertebral column;Viral Proteins

PROJECT_TITLE: Executive Function Impairments in HAND and Aging

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


NIH_SPENDING_CATS: Antimicrobial Resistance;Clinical Research;HIV/AIDS;Infectious Diseases;Pediatric;Pediatric - AIDS

PHR: HIV Drug Resistance, Monitoring and Transmission Rami Kantor, MD NARRATIVE This Mid-Career Investigator Award Renewal will allow me protected time to mentor junior investigators in patient-oriented research, focused on the globally important public health topics of HIV drug resistance, treatment monitoring and transmission, while pursuing my research agenda.

PROGRAM_OFFICER_NAME: CRAWFORD, KEITH W

PROJECT_TERMS: absorption;Acquired Immunodeficiency Syndrome;Address;Adult;Ambulatory Care;Anti-Retroviral Agents;antiretroviral therapy;Award;Basic Science;Bioinformatics;Biological Assay;Boston;career;career development;Child;Clinical;Contact Tracing;COVID-19;Data Analyses;Dedications;design;Development;Doctor of Philosophy;Drug resistance;Ensure;Epidemic;experience;experimental analysis;Faculty;Foundations;Funding;Future;Generations;Genetic;Goals;Grant;Growth and Development function;HIV;HIV drug resistance;Hospitals;human subject;improved;India;Individual;Infrastructure;innovation;inpatient service;Institution;Interdisciplinary Study;International;Kenya;Laboratories;Mentors;Mentorship;Molecular Epidemiology;Monitor;multidisciplinary;participant enrollment;Patient Care;patient oriented research;Persons;Pharmaceutical Preparations;Philosophy;Phylogeny;Population;Postdoctoral Fellow;Prevention;Productivity;Protocols documentation;Public Health;Publications;recruit;Regimen;Research;Research Personnel;Research Support;Resistance;Resources;sample collection;Source;Time;Training;Training Programs;Translational Research;transmission process;Travel;Treatment Failure;Underrepresented Minority;United States National Institutes of Health;Universities;Wages

PROJECT_TITLE: HIV drug resistance, monitoring and transmission

STUDY_SECTION: AIDS

STUDY_SECTION_NAME: Acquired Immunodeficiency Syndrome Research Study Section[AIDS]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Drug Abuse (NIDA only);HIV/AIDS;Harm Reduction for Substance Misuse;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Prevention;Rural Health;Social Determinants of Health;Substance Misuse

ORG_CITY: LEXINGTON

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: PROJECT NARRATIVE Kentucky (KY) is a high priority Ending the HIV Epidemic (EHE) jurisdiction due to heavy rural HIV burden and exceptionally high rates of new HIV diagnoses driven by injection drug use. A central pillar of EHE is the prevention of new HIV infections through scale up of PrEP in key populations, including people who inject drugs (PWID), who are notably impacted by structural challenges to PrEP uptake. This R34 application proposes to develop, integrate and test a low threshold peer-facilitated telehealth (TelePrEP) intervention for Appalachian KY PWID in syringe service programs (SSPs), filling a critical need to implement innovative approaches to mitigate geographic disparities in PrEP access and improve the care cascade among PWID.

PI_NAMEs: SURRATT, HILARY L (contact)

PROGRAM_OFFICER_NAME: JENKINS, RICHARD A

PROJECT_TERMS: access disparities;AIDS prevention;Appalachian Region;Area;Awareness;Biological Markers;care systems;Caring;Collaborations;Communities;Consensus;County;Data;design;Disease Outbreaks;Drug user;Education;efficacy evaluation;Epidemic;experience;Frequencies;geographic disparity;Geography;Harm Reduction;Health;health care availability;Health Personnel;HIV;HIV diagnosis;HIV Infections;housing instability;implementation fidelity;implementation outcomes;implementation strategy;improved;Indiana;Infrastructure;Injecting drug user;injection drug use;innovation;interest;International AIDS;Intervention;Kentucky;Manuals;Measures;medical specialties;men;Methods;Needle-Exchange Programs;North Carolina;novel;novel strategies;Participant;Patient Self-Report;peer;peer support;Persons;point of care;point of care testing;policy recommendation;Population;Poverty;pre-exposure prophylaxis;Prevention;Protocols documentation;Provider;randomized trial;Recommendation;Reporting;Research;Rural;rural area;scale up;Site;social determinants;Social isolation;social stigma;Societies;Stigmatization;Structure;telehealth;Testing;Time;traditional care;transmission process;uptake;Violence;West Virginia;women's diagnosis;Work

PROJECT_TITLE: Optimizing Low Threshold TelePrEP Care in Syringe Service Programs for People who Inject Drugs in Appalachia

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


ORG_CITY: ATLANTA

ORG_DEPT: PATHOLOGY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: NARRATIVE We are proposing comprehensive, mechanistically focused, and highly synergistic studies that will determine the factors promoting in vivo the development and maintenance of terminally-differentiated natural killer (NK) cells with enhanced antibody-dependent cellular cytotoxicity. Furthermore, we will investigate how those factors can be synergistically harnessed with IL-21 and bNAbs treatments to enhance viral control of simian immunodeficiency virus in the absence of antiretroviral therapy.

PI_NAMEs: MULLER-TRUTWIN, MICHAELA ;PAIARDINI, MIRKO  (contact)

PROGRAM_OFFICER_NAME: LAWRENCE, DIANE M

PROJECT_TERMS: Abnormal Cell;African Green Monkey;Antibody Therapy;antibody-dependent cell cytotoxicity;Antibody-Dependent Enhancement;Antigen-Presenting Cells;antiretroviral therapy;B-Lymphocytes;Binding;Blood;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cells;Characteristics;chronic infection;Complex;Control Animal;cytokine;cytotoxic;Data;design;Development;Disease remission;DNA;Education;Epitopes;Exhibits;Fc Receptor;FCGR3B gene;Frequencies;Generations;genome-wide;Goals;Helper-Inducer T-Lymphocyte;HIV;HIV Infections;Immune;Immunophenotyping;Immunotherapy;Impairment;improved;In Situ;in vivo;Infection;Inflammation;Inflammatory;innovation;insight;Intercept;Interferon Type II;interleukin-21;interleukin-21 receptor;Interruption;lymph nodes;Lymphoid;Lymphoid Tissue;Macaca mulatta;Maintenance;Mediating;migration;Modeling;Natural Killer Cells;neutralizing antibody;nonhuman primate;Oncology;Pathogenicity;Peptides;Persons;Phenotype;Pre-Clinical Model;Production;Property;receptor;response;Signal Transduction;SIV;Supporting Cell;synergism;T-Lymphocyte;Testing;Tissues;transcriptome;transcriptome sequencing;Viral;Viral Load result;Viral Physiology;viral rebound;Viral reservoir;Viremia;Virus;Virus Diseases;virus host interaction;Virus Replication

PROJECT_TITLE: Generation of highly differentiated NK cells to synergize with broadly neutralizing antibodies to establish viral control in absence of ART

STUDY_SECTION: HIVD

STUDY_SECTION_NAME: HIV Immunopathogenesis and Vaccine Development Study Section[HIVD]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Hepatitis;Hepatitis - C;Infectious Diseases;Liver Disease;Mental Health;Networking and Information Technology R&D (NITRD);Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Prevention;Rural Health;Social Determinants of Health;Substance Misuse;Telehealth

ORG_CITY: ATHENS

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF GEORGIA

PHR: PROJECT NARRATIVE Amidst the ongoing opioid epidemic, injection drug use has increased in the rural areas of the Deep South, and persons who inject drugs (PWID) are at higher risk of contracting HIV and Hepatitis C Virus (HCV). Given the lack of access to HIV pre-exposure prophylaxis (PrEP) and HCV care and medications for opioid use disorder (MOUD), PWID living in the rural areas of the Deep South are at elevated risk of contracting HIV and HCV, yet few tailored, innovative, trauma-informed approaches are available for this at-risk population. The proposed plan for career development and research focuses on this critical gap by assessing barriers to and facilitators of PrEP, HCV care and MOUD for PWID in the rural areas of the Deep South and then using these findings to develop and pilot-test a tailored, multi-component, trauma-informed, and resilience-based telehealth intervention that aims to increase awareness of and willingness to use PrEP and HCV care and MOUD in this population.

PI_NAMEs: HAIDER, MOHAMMAD RIFAT  (contact)

PROGRAM_OFFICER_NAME: LYNCH, SEAN EDWARD WINTERS

PROJECT_TERMS: Address;Adherence;adverse childhood events;Affect;AIDS prevention;antiretroviral therapy;Attitude;Awareness;Behavior Therapy;behavioral health intervention;Behavioral Sciences;career;career development;Caring;Collaborations;Continuity of Patient Care;Contracts;Coping Skills;Credentialing;Crossover Design;decrease resilience;Deep South;design;Development;Disease Outbreaks;Drug usage;Environment;Epidemic;epidemic virus;Evidence based intervention;experience;Face;formative assessment;Goals;Health;health disparity;Health Personnel;Health Services Accessibility;Hepatitis C;Hepatitis C virus;high risk;HIV;HIV Infections;HIV risk;HIV/HCV;Human immunodeficiency virus test;Improve Access;improved;Individual;Infection;Injecting drug user;injection drug use;Injections;innovation;Intervention;Interview;Knowledge;late life;Lead;Link;medication for opioid use disorder;Mentors;Methods;Modeling;National Institute of Drug Abuse;Needle Sharing;novel;opioid epidemic;opioid overdose;Outcome;Perception;Phase;pilot test;pilot trial;Policy Maker;Population;Populations at Risk;post intervention;pre-exposure prophylaxis;Prevention;prevention service;primary outcome;Productivity;programs;Provider;Randomized;randomized trial;recruit;Research;research and development;Research Personnel;resilience;Resources;Risk;Risk Behaviors;Rural;rural area;rural counties;rural setting;secondary outcome;Sex Behavior;Site;skills;social;social health determinants;social stigma;South Carolina;Stress and Coping;Surveys;Techniques;Technology;telehealth;Testing;theories;therapy design;therapy development;Training;Transact;Trauma;Trauma Research;trial design;United States;Universities;uptake;usability;Waiting Lists;willingness

PROJECT_TITLE: Trauma-informed, resilience-based telehealth intervention for improving HIV prevention and HCV care for persons who inject drugs in the Deep South


NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative:  Of the many examples of cellular trans-differentiation and reprogramming in the research literature, very few if any efficiently generate new cells that exhibit terminal differentiation suitable for cellular therapeutics and disease modeling. In the past funding periods of my two grants that converge into this R35 application, our laboratory has found that genes residing in particular varieties of chromosomal condensation, known as H3K9me3-heterochromatin, are refractory to activation during trans-differentiation and reprogramming. The present application uses a research environment for diversity, equity, and inclusion to bring together diverse technologies and cellular systems to understand how gene regulatory proteins overcome the heterochromatin barrier and to apply the information to create more differentiated cells for therapeutics and disease modeling.

PI_NAMEs: ZARET, KENNETH  (contact)

PROGRAM_OFFICER_NAME: SALAZAR, DESIREE LYNN

PROJECT_TERMS: Amino Acids;Binding;Biochemical;Categories;Cell Culture Techniques;Cell Differentiation process;Cell Fate Control;Cell Reprogramming;Cell Therapy;cell type;Cells;Chromatin;Chromosomes;Deoxyribonucleases;disease model;DNA;Enabling Factors;Environment;equity, diversity, and inclusion;Event;Exhibits;Funding;Gene Expression Regulation;gene repression;Genes;Genetic;genetic approach;genetic regulatory protein;Genetic Transcription;Genomics;Goals;Grant;Heterochromatin;Histones;improved;In Vitro;in vivo;insight;knock-down;Laboratories;Licensing Factor;Literature;Mus;Nucleosomes;Physical condensation;Proteins;reconstitution;Refractory;Research;Resistance;single molecule;System;Technology;Tertiary Protein Structure;Therapeutic;transcription factor;transdifferentiation;Work;XCL1 gene

PROJECT_TITLE: Transcription Factors Overcoming Chromatin Barriers to Control Cell Fate

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;HIV/AIDS;Health Services;Mental Health;Pediatric;Pediatric - AIDS;Prevention

ORG_CITY: TALLAHASSEE

ORG_NAME: FLORIDA STATE UNIVERSITY

ORG_STATE: FL

PHR: PROJECT NARRATIVE If successful in building MI skills among HIV counseling support staff, iMI4HIV has the potential to shift how MI training is provided to these critical providers of HIV care services. Furthermore, the program can be housed at FSU for use by AETCs throughout the country to provide additional MI training to their client agencies, used to train HIV treatment counselors in research studies, and provide training opportunities for other community-based agencies working to End the HIV Epidemic. Lastly, it can provide a training model that can be adapted to training providers working with other patient populations.

PI_NAMEs: BALAN, IVAN C (contact)

PROGRAM_OFFICER_NAME: GREENWOOD, GREGORY LOUIS

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;Adolescent;Adult;Affect;AIDS education;AIDS prevention;behavior change;care outcomes;care systems;Caribbean region;Caring;Client;collaborative approach;Communication;Communication Research;Communities;Community Health Aides;Community Healthcare;Competence;Continuity of Patient Care;Counseling;Country;Custom;design;Deterioration;E-learning;Educational workshop;efficacy evaluation;Epidemic;Ethnic Origin;experience;Florida;Goals;Guidelines;Health;health communication;Health Personnel;Healthcare;Healthcare Systems;HIV;improved;improved outcome;Individual;interest;Internet;Interview;Language;Learning;Learning Skill;Life Experience;Measures;Methods;Modeling;motivational enhancement therapy;New York;Outcome;Participant;patient population;Patients;peer;Professional counselor;programs;Provider;Psychological reinforcement;Randomized, Controlled Trials;Research;Research Infrastructure;research study;Resources;Services;skill acquisition;skills;skills training;Technology;Training;Training and Education;training opportunity;Training Programs;United States Dept. of Health and Human Services;United States National Institutes of Health;Universities;virtual;Waiting Lists;Work;Workforce Development

PROJECT_TITLE: Interactive Internet-based Motivational Interviewing Training for HIV Counseling Support Staff to Improve Health Communication in HIV Care Interactions

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Clinical Research;Genetics;HIV/AIDS;Infectious Diseases;Sexually Transmitted Infections

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

ORG_STATE: NY

PHR: Herpes simplex virus type 2 (HSV-2) is one of the most significant factors fueling the global HIV epidemic and coinfection is associated with higher HIV plasma viral loads and increased rates of HIV transmission. The goal of this application is to identify the mechanisms by defining the transcriptional responses to HSV-2 in HIV-infected individuals using primary cells and genital skin biopsies obtained during HSV-2 recurrences and to determine how these responses promote HIV replication. The results obtained will have broad implications and accelerate the development of strategies for HIV eradication.

PI_NAMEs: HEROLD, BETSY C. (contact)

PROGRAM_OFFICER_NAME: SHARP, GERALD B

PROJECT_TERMS: Acceleration;Affect;Anti-viral Therapy;antiretroviral therapy;APOCEC3G gene;ATAC-seq;Bar Codes;biobank;Biological;Biological Models;Biopsy;CD4 Positive T Lymphocytes;Cell Line;Cell model;Cell Separation;cell type;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Clinical;co-infection;Coculture Techniques;Complex;CRISPR/Cas technology;Development;Disease Outbreaks;Disease Progression;Epidemic;epidemiology study;Epigenetic Process;epigenetic silencing;Epithelial Cells;Foundations;Frequencies;Gene Expression;Genetic Transcription;genital herpes;Genitalia;Goals;Histones;HIV;HIV Infections;HIV Long Terminal Repeat;HIV Seronegativity;HIV-1;Human Herpesvirus 2;Immune;Immunofluorescence Immunologic;In Situ;Individual;Infection;knock-down;Knock-out;Lesion;Link;lonely individuals;Maintenance;MALAT1 gene;Maps;Mediating;Messenger RNA;Modeling;Molecular;Mucous Membrane;novel strategies;Pathway interactions;Patients;peripheral blood;Peripheral Blood Mononuclear Cell;Persons;pharmacologic;Phenotype;Plasma;Polycomb;prevent;Productivity;protein expression;Proteins;Proteomics;recruit;Recurrence;Repression;Resolution;response;Risk;Role;Simplexvirus;single-cell RNA sequencing;Site;Skin;skin biopsy;syndemic;T-Cell Activation;T-Lymphocyte;Techniques;Technology;Testing;Time;Tissues;TNF gene;Transcript;transcriptome;transcriptome sequencing;transmission process;Untranslated RNA;Viral;Viral Load result;Viremia;Virus Diseases;Virus Replication

PROJECT_TITLE: Mechanisms Underlying the HIV-HSV-2 Syndemic


ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE The ultimate solution for HIV infected people on lifelong therapy is to find a cure. This study will use lymph node and guts from a cohort of ART suppressed individuals, some of whom interrupted therapy following a bNAB intervention. The study will seek to identify barriers to HIV eradication in tissues and perform in vitro testing of therapeuitic strategies for eliminating HIV in tissues for a cure.

PI_NAMEs: NDHLOVU, ZAZA MTINE (contact)

PROGRAM_OFFICER_NAME: NOVAK, LEIA KAYE

PROJECT_TERMS: Anatomy;anergy;Antibodies;antiretroviral therapy;B-Lymphocytes;BCL1 Oncogene;Biological Assay;Biopsy;Blood specimen;Blood Volume;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cells;clinically relevant;cohort;Collaborations;Coupled;cytotoxic;cytotoxic CD8 T cells;Data;design;Development;DNA;Education;Environment;Epidemic;Exclusion;exhaustion;Female;Foundations;Functional impairment;Funding;Genes;Genetic Transcription;Goals;Grant;Gut associated lymphoid tissue;Health;Heart;Helper-Inducer T-Lymphocyte;HIV;HIV Infections;HIV Seropositivity;HIV therapy;Human;Image;Immune;Immune response;immunoregulation;improved;In Situ Hybridization;In Vitro;in vitro testing;Individual;infected B cell;Infiltration;Inflammatory;innovation;Interleukin-10;Interleukin-15;Interruption;Intervention;Intervention Studies;Link;Lymph Node Dissections;lymph nodes;Lymphoid Follicle;Macaca;Measures;Mediating;Microanatomy;microfluidic technology;Microscopy;Modeling;Molecular;next generation;novel strategies;novel therapeutics;Organ;organ on a chip;Outcome;peripheral blood;Persons;Process;Proviruses;Regulatory T-Lymphocyte;Research;Resolution;Sampling;secondary lymphoid organ;Signal Transduction;single-cell RNA sequencing;Site;Source;South Africa;Spleen;Structure of germinal center of lymph node;T cell infiltration;T cell response;T-Lymphocyte Subsets;Technology;Testing;Therapeutic;Tissue Sample;Tissues;transcriptomics;tumor-immune system interactions;Viral;viral rebound;Viral reservoir;Virus

PROJECT_TITLE: Spatial analysis of tissue immune responses in persistent HIV infection


NIH_SPENDING_CATS: Aging;Brain Disorders;Cerebrovascular;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Mental Health;Microbiome;Neurosciences;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: CORAL GABLES

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

PHR: Project Narrative There is a strong correlation between chronic drug use and increase susceptibility to HIV infection. Chronic drug users accounts for approximately a third of all cases of AIDS in the USA and the progression to HAND is markedly accelerated in opiate drug abusers; currently most HIV patients are on ART however, the long term consequence on neurocognition has not been delineated. This proposal postulates that alteration in the GUT microbiome results in the secretion of Bacterial extracellular vesicles that are able to cross barriers and travel long distances to modulates microglial cells thus contributing to neurocognitive deficits that are persistence in people living with HIV that are substance users.

PI_NAMEs: ROY, SABITA  (contact)

PROGRAM_OFFICER_NAME: WU, DA-YU

PROJECT_TERMS: Acceleration;Acquired Immunodeficiency Syndrome;Alzheimer's Disease;Animal Model;Anxiety;autism spectrum disorder;Bacteria;bacterial community;Behavior Disorders;Biology;Blood - brain barrier anatomy;Brain;Cells;Central Nervous System;Cerebral endothelium;Chronic;Clinical;clinically relevant;Coculture Techniques;Communication;comorbidity;Data;Development;drug abuser;Drug usage;Drug user;dysbiosis;Elderly;Endotoxins;Epithelium;extracellular;extracellular vesicles;gastrointestinal epithelium;Gene Expression;Gram-Positive Bacteria;Grant;gut microbes;gut microbiome;gut-brain axis;Hand;high reward;high risk;HIV;HIV Infections;Human;Immune;In Vitro;in vivo;Intestinal permeability;Lipids;Macrophage;Mediator;Mental Depression;Metabolic;microbial;microbiome;microbiota-gut-brain axis;Microglia;Modeling;Morphine;Mus;nano;Nerve;Neurocognition;Neurocognitive Deficit;neuropsychiatric disorder;novel;Nucleic Acids;Opioid;opioid abuse;opioid use;opioid use disorder;Parkinson Disease;Pathogenicity;Patients;Permeability;Persons;Pharmacologic Substance;Play;pre-clinical;Predisposition;Probiotics;Process;Proteins;Publishing;RNA;Role;Signal Transduction;small molecule;stool sample;substance use;Substance Use Disorder;substance user;symbiont;Testing;Therapeutic;Tissues;Travel;Vesicle

PROJECT_TITLE: Extracellular RNA carrier subclasses in processes relevant to Substance Use Disorders or HIV infection


ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

PHR: NARRATIVE The proper assembly of membrane proteins is of critical importance to cellular physiology, yet we do not have a fundamental understanding of the physical reasons why membrane proteins form stable assemblies in the hydrophobic membrane. In this project, we will study the equilibrium dimerization reaction of the CLC-ec1 Cl- /H+ antiporter as a model system to dissect the thermodynamic driving forces underlying membrane protein association in lipid bilayers. The results from this study will identify the molecular mechanisms for how protein sequence, lipid composition and general anesthetics modulate stability, and thereby lay down a physical foundation for the development of new strategies aimed at correcting stability defects in membrane protein folding diseases.

PI_NAMEs: ROBERTSON, JANICE L (contact)

PROGRAM_OFFICER_NAME: TAYLOR, VERONICA

PROJECT_TERMS: Amino Acid Sequence;antiporter;Biological Models;Cell membrane;Cell Physiology;Cells;CLC Gene;Defect;Development;Dimerization;Dissociation;driving force;enthalpy;Entropy;Equilibrium;experimental study;Fluorescence;Foundations;Free Energy;General anesthetic drugs;Hydrophobicity;Kinetics;Laboratories;Lipid Bilayers;Lipids;Measurement;Measures;Membrane;membrane assembly;Membrane Proteins;Methods;Microscopy;Molecular;molecular modeling;Mutation;Nutrient;pharmacologic;Phase;Physiology;Protein-Folding Disease;Proteins;Reaction;Regulation;single molecule;Solvents;Structure;Temperature;Theoretical model;theories;Thermodynamics;Time;wasting

PROJECT_TITLE: Driving forces of membrane protein assembly in membranes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(02)-M]


NIH_SPENDING_CATS: HIV/AIDS;Infectious Diseases

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: Project Narrative In this project, we will capitalize on advanced technologies to examine how HIV-1 enters a host cell and to dissect the mechanisms of entry inhibition. The goal is to transform our understanding of early steps of HIV-1 infection and to inform the design of novel antiviral inhibitors and vaccines.

PI_NAMEs: CHEN, BING  (contact)

PROGRAM_OFFICER_NAME: LACOURCIERE, GERARD

PROJECT_TERMS: 2019-nCoV;Address;Antibodies;Binding;Binding Sites;CCR5 gene;CD4 Antigens;Cell surface;Cells;chemokine receptor;Complex;Cryo-electron tomography;Cryoelectron Microscopy;CXCR4 gene;Cytoplasmic Tail;design;Detergents;Development;Ebola;Electron Microscopy;electron tomography;env Gene Products;FDA approved;Future;Glycoproteins;glycosylation;Goals;gp160;HIV Envelope Protein gp120;HIV-1;Human;improved;Infection;Infection prevention;Influenza Hemagglutinin;inhibitor;insight;Intervention;Length;Lipid Bilayers;Lipids;Mediating;Membrane;membrane assembly;Membrane Fusion;Micelles;Molecular;Molecular Conformation;Molecular Mechanisms of Action;Monoclonal Antibodies;movie;nanodisk;neutralizing antibody;novel;particle;Pilot Projects;Process;Property;Reaction;receptor;receptor binding;reconstitution;Resolution;Role;SARS-CoV-2 spike protein;Series;small molecule;structural biology;Structure;Surface;System;Technology;Therapeutic;Therapeutic Agents;therapy development;Transmembrane Domain;vaccine development;Viral;Viral Fusion Proteins;Viral Vaccines;Virion;Virus;Virus Inhibitors;Visualization

PROJECT_TITLE: HIV-1 membrane fusion and inhibition

STUDY_SECTION: HVCD

STUDY_SECTION_NAME: HIV Molecular Virology, Cell Biology, and Drug Development Study Section[HVCD]


NIH_SPENDING_CATS: Clinical Research;Diabetes;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Maternal Morbidity and Mortality;Obesity;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: NEW YORK

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: PROJECT NARRATIVE HIV and gestational diabetes both increase the risk of developing type 2 diabetes postpartum, but it is not known whether HIV adds to the risks brought on by gestational diabetes. I propose a longitudinal cohort study following pregnant women with gestational diabetes with and without HIV over 2 years postpartum to 1) determine how HIV affects the development of type 2 diabetes or its precursor, pre-diabetes and 2) characterize the longitudinal effect of HIV on beta cell function, which is a major contributor to the pathophysiology of type 2 diabetes. The results of this study will be used to develop lifestyle or pharmacologic interventions to prevent diabetes in South Asian women with and without HIV.

PI_NAMEs: CHEBROLU, PUJA  (contact)

PROGRAM_OFFICER_NAME: LAWRENCE, JEAN M

PROJECT_TERMS: Acceleration;Affect;Asian Women;base;Beta Cell;Biometry;Body mass index;Body Weight decreased;career development;cell injury;Cell Physiology;Cellular Stress;Cessation of life;Clinical Trials;cohort;Collaborations;Conduct Clinical Trials;Country;Cox Proportional Hazards Models;Data;design;Development;Development Plans;Diabetes Mellitus;Diabetes prevention;diabetes risk;efficacy testing;Environment;Epidemiology;Equation;Fasting;Fatty acid glycerol esters;Functional disorder;Future;Gestational Diabetes;Glucose;glucose tolerance;Goals;Government;hazard;high risk;high risk population;HIV;HIV Infections;indexing;India;inflammatory marker;Insulin;Insulin Resistance;Intervention;Intervention Studies;Kidney Diseases;Leadership;Life Style;Lifestyle Therapy;Literature;Longitudinal cohort study;Longitudinal Studies;longitudinal, prospective study;Low income;Measures;medical schools;Medicine;Mentors;Mentorship;Myocardial Infarction;Non obese;Non-Insulin-Dependent Diabetes Mellitus;Nonesterified Fatty Acids;obese person;OGTT;Overweight;Pathogenesis;Persons;pharmacologic;Physicians;Population;Postpartum Period;postpartum weight;Postpartum Women;Prediabetes syndrome;Predisposition;Pregnancy;Pregnant Women;Preparation;prevent;Prevention;Prevention Guidelines;Production;progression risk;Publications;Recording of previous events;Research;Research Personnel;Resistance;Resource-limited setting;Risk;Scientist;Serum;skills;South Asian;Stroke;Structure of beta Cell of islet;Testing;Time;TNF gene;Training;Visceral fat;Woman;Work;World Health Organization;young woman

PROJECT_TITLE: Time course and predictors of progression to postpartum prediabetes and type 2 diabetes in HIV: a prospective longitudinal study of low-income Indian women

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


ED_INST_TYPE: SCHOOLS OF PHARMACY

PHR: Project Narrative New HIV treatment, prevention and cure strategies are needed to end the epidemic. Sharing scientific data will accelerate their discovery. We will transform an HIV pharmacology database into a widely used, data-sharing service by expanding data archives, promoting scientific exploration, and characterizing user preferences.

PI_NAMEs: COTTRELL, MACKENZIE  (contact)

PROGRAM_OFFICER_NAME: MCKAIG, ROSEMARY G

PROJECT_TERMS: Acceleration;Acquired Immunodeficiency Syndrome;Advertising;Analytical Chemistry;Anatomy;Anti-Retroviral Agents;archived data;Archives;Automobile Driving;Back;base;Biological;Biomedical Research;Characteristics;Clinical;clinical data repository;Clinical Pharmacology;Clinical Research;Communities;Data;data access;data archive;Data Files;data management;Data Pooling;data portal;data repository;data sharing;Databases;design;Development;Disparate;drug development;Drug Kinetics;Ensure;Epidemic;FAIR principles;Focus Groups;Funding;Goals;HIV;HIV/AIDS;improved;in silico;Incidence;Individual;Industrialization;Infection;informatics tool;innovation;International;Knowledge;Laboratories;meetings;Modeling;novel therapeutic intervention;novel therapeutics;Ontology;Output;Participant;Peer Review;Pharmaceutical Preparations;pharmacodynamic model;Pharmacology;Physiological;Policies;Population;pre-clinical;preclinical study;preference;Prevention;Procedures;Process;programs;prototype;Publications;Readability;Recommendation;Research;Research Design;Research Personnel;Research Project Grants;Resources;Sampling;Services;Standardization;Survey Methodology;symposium;System;Therapeutic;Time;tool;United States National Institutes of Health

PROJECT_TITLE: HIV Pharmacology Data Repository

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BBBT-T (55)]


ORG_CITY: NEW HAVEN

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Despite effective antiretroviral therapy, HIV-1-infected cells persist and proliferate. Using cutting-edge single-cell multi-omic profiling, we will examine mechanisms of HIV-1 persistence and decipher T cell clonal expansion dynamics. Understanding the cellular environment of HIV-1-infected cells will guide the design of therapeutic strategies for HIV-1 eradication.

PI_NAMEs: HO, YA-CHI  (contact)

PROJECT_TERMS: Accounting;Acute;Anatomy;Antigen Presentation;Antigens;antimicrobial;antiretroviral therapy;ATAC-seq;Blood;CD4 Positive T Lymphocytes;cell killing;cell motility;Cell Proliferation;Cell Separation;Cell Survival;cell type;Cells;Clonal Expansion;Clone Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Cues;cytokine;cytotoxic;cytotoxic CD8 T cells;design;Dimensions;DNA;Environment;Enzymes;exhaustion;FDA approved;Flow Cytometry;Funding;Genetic Transcription;genome-wide;Goals;Heterogeneity;high dimensionality;HIV-1;Immune;immune clearance;Immune Evasion;Immune response;Immunity;Individual;Infection;inhibitor;integration site;Knock-out;lenalidomide;Length;Location;Mediating;Membrane Proteins;Memory;memory CD4 T lymphocyte;mesenteric lymph node;Methods;migration;Mothers;multiple omics;overexpression;peripheral blood;Persons;Pharmaceutical Preparations;Phylogenetic Analysis;polarized cell;programs;Proliferating;protein biomarkers;protein profiling;restoration;RNA;Role;Sampling;Site;Specificity;T cell clonality;T cell receptor repertoire sequencing;T-Cell Depletion;T-Cell Proliferation;T-Cell Receptor;T-Lymphocyte;T-Lymphocyte Subsets;Testing;Therapeutic;therapeutic target;Time;Tissues;trafficking;transcription factor;transcriptome;transcriptome sequencing;Viral;Viral Cytopathogenic Effect

PROJECT_TITLE: Role of clonal expansion in HIV-1 persistence


NIH_SPENDING_CATS: Genetics;HIV/AIDS;Infectious Diseases

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE  When engaged at the right time and place, activation of the innate immune response can block HIV infection. However, we lack a fundamental understanding of how appropriate innate immune responses are regulated in host cells. This project will use new tools to study the genetic circuitry that regulates innate immune responses and HIV replication, and could lead to innovative therapies that improve anti-HIV immune responses and target the virus reservoir.

PI_NAMEs: JOHNSON, JARROD SEAN (contact)

PROGRAM_OFFICER_NAME: SHANKAR, UDAY K

PROJECT_TERMS: acute infection;Acute Myelocytic Leukemia;adaptive immunity;Address;Affect;Anti-viral Response;APOCEC3G gene;Binding;Biological Assay;CBFB gene;cell type;Cells;ChIP-seq;Chromatin;cofactor;Complex;CRISPR/Cas technology;Data;Dendritic Cells;Detection;differential expression;Educational process of instructing;Equilibrium;experimental study;Family;Family member;Gene Expression;gene network;gene regulatory network;Gene Targeting;Genes;Genetic;Genetic study;Genetic Transcription;genome-wide;Goals;HIV;HIV Infections;HIV-1;Host Defense;Immune;immune activation;Immune response;Immune Targeting;improved;Infection;Inflammation;Inflammatory;Inflammatory Response;inhibitor;Innate Immune Response;innate immune sensing;Innovative Therapy;Interferon Type II;Interferons;knock-down;Knock-out;Knowledge;Life Cycle Stages;loss of function mutation;Macrophage;Malignant Breast Neoplasm;Maps;Methods;Microbe;Modeling;Molecular;monocyte;mutant;Myelogenous;Myeloid Cells;Natural Immunity;novel;nucleofection;Pathogenesis;Pathway interactions;pharmacologic;Post-Translational Modification Site;Predisposition;Process;Production;Protein Isoforms;Regulation;response;Ribonucleoproteins;RNA Interference;Role;RUNX1 gene;Signal Transduction;small hairpin RNA;System;T-Lymphocyte;Testing;Time;tool;transcription factor;Transcriptional Activation;transcriptome sequencing;Up-Regulation;Validation;vif Gene Products;Viral Genes;Viral reservoir;Virus;Virus Replication;Work

PROJECT_TITLE: Regulation and Manipulation of Innate Immunity During HIV Infection


NIH_SPENDING_CATS: Biotechnology;HIV/AIDS

ORG_CITY: COLUMBIA

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

PHR: This study will identify new aptamers that differentiate among HIV-1 capsid assembly states and develop an aptamer-mediated, capsid assembly state-specific affinity purification method paired with crosslinking mass spectrometry to identify novel capsid-associated host factors. This work will generate new tools and methods to support future studies that improve our understanding of HIV-1 capsid structure-function relationships, the role of capsid assembly forms in diverse HIV-1 replication steps, and capsid-host factor interactions, leading to a better understanding of the role of capsid in HIV-1 biology. Future work beyond this proposal could significantly impact the discovery of anti-HIV drugs that target novel aptamer-binding sites on capsid protein, define the role(s) of specific capsid assembly forms in HIV biology, and be extended to the capsids of other viruses of public health importance.

PI_NAMEs: LANGE, MARGARET J (contact)

PROJECT_TERMS: Address;Affinity;Affinity Chromatography;Amino Acids;Anti-HIV Agents;aptamer;Binding;Binding Proteins;Binding Sites;Biological;Biology;Capsid;Capsid Proteins;Cell Death;Cell Nucleus;Cell Physiology;Cells;Cellular biology;Complex;Cone;crosslink;Defect;Dependence;dimer;Dissociation;Drug resistance;Elements;Equilibrium;Evaluation;Event;Fullerenes;Future;gag Gene Products;Generations;Genetic;Goals;HIV;HIV-1;Immune response;improved;Individual;inhibitor;Integration Host Factors;interest;Investigation;knock-down;Knock-out;Knowledge;Label;Laboratories;Link;Maintenance;Mass Spectrum Analysis;Mediating;Membrane Proteins;Methods;Microscopy;Modification;Molecular Conformation;mutant;Mutation;new therapeutic target;novel;Nuclear Import;Nucleic Acids;Peptide Hydrolases;Pharmaceutical Preparations;Phenotype;Polyproteins;Population;Post-Translational Protein Processing;protein function;Proteins;Public Health;Reagent;Resolution;Reverse Transcription;RNA;Role;Site;small molecule;Specificity;Structure;Structure-Activity Relationship;Techniques;therapeutic development;therapeutic target;tool;trafficking;Viral;viral resistance;Virus;Virus Assembly;Work

PROJECT_TITLE: Aptamers that discriminate among HIV-1 capsid assembly states


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Cerebrovascular;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Methamphetamine;Neurosciences;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Stimulant Use and Misuse;Substance Misuse

PHR: PROJECT NARRATIVE This research aims to investigate the effects of methamphetamine (METH) abuse and HIV-1 infection on the brain, specifically on the cells responsible for creating new neural cells, called neural progenitor cells (NPCs). This application is focused on how the migration of NPCs and interactions with brain pericytes may be affected by METH and HIV-1. Our goal is to better understand these impacts and find new ways to treat neurological issues in people living with HIV-1 who abuse METH.

PI_NAMEs: PARK, MIN SEON  (contact)

PROGRAM_OFFICER_NAME: BORGMANN, KATHLEEN RUTH

PROJECT_TERMS: Actins;Acute;adult neurogenesis;Affect;American;antiretroviral therapy;Area;Astrocytes;Blood;Blood - brain barrier anatomy;blood-brain barrier disruption;Brain;brain pericytes;Cell Separation;Cells;cerebral capillary;cerebral microvasculature;chemokine;Chronic;combat;Communication;cytokine;Data;Development;disease transmission;Encephalitis;Endothelial Cells;Exposure to;ezrin;Functional disorder;global health;Goals;Growth Factor;HIV;HIV Infections;HIV Seropositivity;HIV-1;HIV-2;improved;In Vitro;Individual;Infection;Inflammatory;Injections;innovation;insight;Judgment;Knowledge;Label;Laboratories;Laminin;lateral ventricle;Lead;Lesion;Ligands;Light;Link;Mediating;Membrane;Methamphetamine;methamphetamine abuse;methamphetamine effect;methamphetamine exposure;methamphetamine use;Methamphetamine use disorder;MicroRNAs;migration;Molecular;Morphology;mRNA Expression;Mus;Needle Sharing;nerve stem cell;Nervous System Disorder;Neurites;Neurocognitive;neurogenesis;Neurologic;Neurons;neurotoxic;neurotoxicity;novel;Nutrient;Pericytes;Persons;Phosphorylation;Plasma;Population;Process;protein expression;putamen;Reporting;Research;response;Risk;Risk Behaviors;Role;Sampling;stem cell migration;Substance abuse problem;substance use;subventricular zone;therapeutic target;therapeutically effective;Time;United States;Unsafe Sex;Viral Load result;Virus;Work

PROJECT_TITLE: Impact of miRNAs on adult neurogenesis following exposure to methamphetamine and HIV-1 Infection


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Brain Disorders;Cannabinoid Research;Clinical Research;Drug Abuse (NIDA only);Endocannabinoid System Research;Genetics;HIV/AIDS;Human Genome;Infectious Diseases;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Substance Misuse;Therapeutic Cannabinoid Research

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: PROJECT NARRATIVE HIV-1 associated neurocognitive diseases (HAND) affect up to 50% of people with HIV-1 (PWH), including those receiving antiretroviral therapies (ART), and there are currently no effective treatments available. This project aims to investigate the role of the endocannabinoid system (ECS) in the development of HAND. By gaining a deeper understanding of the mechanisms by which selective cannabinoid receptor agonists modulate neuroinflammation, we may be able to develop new therapeutic approaches to treat HAND and improve the quality of life for PWH.

PI_NAMEs: MIN, ALICE KYUNGSUN (contact)

PROGRAM_OFFICER_NAME: VEMURI, KIRAN R V

PROJECT_TERMS: 3-Dimensional;Advisory Committees;Affect;Agonist;American;Anti-Inflammatory Agents;antiretroviral therapy;Area;Award;Biological Models;Brain;cannabinoid receptor;career;career development;Cell Communication;Cell Culture Techniques;Cells;Central Nervous System;Chromium;Chronic;CNR1 gene;CNR2 gene;Collaborations;Communicable Diseases;Communication;comorbidity;cytokine;Data;Dementia;Development;Development Plans;Disease;effective therapy;endogenous cannabinoid system;Environment;epigenomics;epitranscriptomics;experimental study;Faculty;Family;Fellowship;Flow Cytometry;Foundations;Future;Genome Mappings;Goals;HIV;HIV-1;HIV-associated neurocognitive disorder;Human;human induced pluripotent stem cells;human tissue;humanized mouse;Immunology;improved;In Vitro;in vivo;induced pluripotent stem cell;Infection;Inflammasome;Inflammatory;inflammatory marker;insight;integration site;Internal Medicine;Knowledge;Laboratories;marenostrin;medical schools;Mentors;Microbiology;Microglia;Molecular;mortality risk;mouse model;multidisciplinary;neuroAIDS;Neurocognitive;Neurocognitive Deficit;neurocognitive disorder;neuroinflammation;neuron apoptosis;Neurons;neuropathology;Neurosciences;neurotoxic;novel;novel therapeutic intervention;novel therapeutics;Pathway interactions;Peripheral Blood Mononuclear Cell;Persons;Physicians;Positioning Attribute;Principal Investigator;Productivity;programs;Property;Quality of life;Research;Research Activity;Residencies;Residual state;Resources;Role;Scientist;single-cell RNA sequencing;skills;standard care;stem cell biology;System;T-Lymphocyte;targeted treatment;Technology;Testing;therapeutic target;Time;Training;transcriptomic profiling;United States;Viral;virology;Virus Integration;Xenograft procedure

PROJECT_TITLE: Cannabinoid Receptor Type 2 Agonist as Potential Therapy for Neuroinflammation in HIV-1 Associated Neurocognitive Disorders


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Contraception/Reproduction;Genetics;HIV/AIDS;Infectious Diseases;Microbiome;Prevention;Sexually Transmitted Infections;Topical Microbicides;Women's Health Research

ORG_CITY: RIVERSIDE

ORG_NAME: UNIVERSITY OF CALIFORNIA RIVERSIDE

ORG_STATE: CA

PHR: PROJECT NARRATIVE Bacterial Vaginosis (BV) affects millions of women annually, leading to increased vaginal inflammation, elevated susceptibility to STIs, adverse birth outcomes, and a reduction in quality of life. However, our understanding of the factors influencing transitions to BV, as well as the mechanisms underlying its persistence and recurrence, are incomplete. This project utilizes integrative metagenomics to characterize the interplay between vaginal viral and bacterial communities, how they are shaped by contraceptive use, and how these dynamics may alter HIV acquisition risk.

PI_NAMEs: BROWN, BRYAN P (contact)

PROGRAM_OFFICER_NAME: RUSSO, DENISE

PROJECT_TERMS: adverse birth outcomes;Affect;Anaerobic Bacteria;Antibiotic Therapy;Attention;Bacteria;bacterial community;Bacterial Genome;Bacterial Vaginosis;bacteriome;Bacteriophages;Biological;Biological Assay;Birth;Cells;cervicovaginal;chronic infection;Clinical;clinically relevant;cohort;Communities;Contraceptive Agents;Contraceptive Usage;Copper Intrauterine Devices;cytokine;Cytolysis;Data;data integration;demographics;DNA;DNA Viruses;Enrollment;Environment;Eukaryota;Exhibits;experience;experimental study;Family;female reproductive tract;follow-up;functional genomics;Growth;Heavy Metals;Herpesviridae;HIV;HIV Seropositivity;Hormonal;hormonal contraception;In Vitro;Incidence;Inflammation;Inflammatory;Infrastructure;insight;Ions;Lactobacillus;longitudinal design;Lymphocyte;Lysogeny;lytic replication;Maternal Health;Measurement;Measures;Mediator;member;metagenome;Metagenomics;microbial;microbiome;Mucosal Immune Responses;Mucositis;Outcome;Oxidative Stress;Papillomavirus;Participant;particle;Play;Predisposition;Prophage Inductions;Prophages;Quality of life;Randomized;recruit;Recurrence;Reproductive Health;Research;Risk;RNA;Role;Sampling;seroconversion;Shapes;Shotgun Sequencing;Shotguns;stressor;Structure;Testing;Vagina;Vaginal Discharge;Viral;virome;Virus;Visit;Woman;Work

PROJECT_TITLE: Viral determinants of Bacterial Vaginosis and HIV acquisition risk in the female genital tract


NIH_SPENDING_CATS: Bioengineering;Biotechnology

ORG_CITY: WEST LAFAYETTE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: Project Narrative This project is devoted to novel ion chemistries and instrumentation for mass measurement and structural characterization of intact bio-polymers and their complexes. Emphasis is placed on the gas- phase attachment of multiply-charged ions of selected mass and charge to oppositely-charged ions derived from complex bio-polymer mixtures, including heterogeneous complexes, such as molecular machines and viruses. This effort addresses key limitations in the current state-of-the-art in top-down proteomics and native mass spectrometry.

PI_NAMEs: MCLUCKEY, SCOTT A (contact)

PROGRAM_OFFICER_NAME: BARNES, CHARLES ASHLEY

PROJECT_TERMS: Address;Anions;Area;Biomedical Research;Biopolymers;Charge;Chemistry;Complex;Complex Mixtures;Development;Device or Instrument Development;Digestion;digital;Electrospray Ionization;Electrostatics;Excision;experimental study;Gases;improved;instrumentation;interest;ionization;Ions;macromolecule;Mass Spectrum Analysis;Measurement;Metals;Molecular;Molecular Machines;novel;Nucleic Acids;operation;Phase;Proteins;Proteomics;Reaction;Reagent;Science;Surface;tandem mass spectrometry;tool;virtual;Virus

PROJECT_TITLE: Novel Ion Chemistry and Instrument Development for the Characterization of Proteins, Nucleic Acids, and Heterogeneous Bio-complexes via Tandem Mass Spectrometry

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]