NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Genetic Testing;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Human Genome;Mental Health;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Telehealth

ORG_CITY: RICHMOND

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: PROJECT NARRATIVE The overarching goal of this proposed multi-center research is to compare and contrast the nature of cancer genetic counseling encounters and patient-centered outcomes between Black and White patients in the naturalistic clinical setting. We will conduct an observational study with a convergent mixed methods research design, analyzing video-recorded cancer genetic counseling encounters both qualitatively and quantitatively and linking those data to pre-encounter survey data (to identify provider factors associated with the nature of cancer genetic counseling encounters), post-encounter survey data (to assess the role of cancer genetic counseling encounters in predicting self-reported patient-centered outcomes), and data from medical chart reviews (to assess the role of cancer genetic counseling encounters in predicting genetic test uptake). Findings from this proposed study enables researchers to identify specific aspects of cancer genetic counseling encounters (i.e., patient-counselor communication and clinical recommendations) that are modifiable and are directly associated with patient-centered outcomes.

PI_NAMEs: HAGIWARA, NAO ;QUILLIN, JOHN M. (contact)

PROGRAM_OFFICER_NAME: FERRER, REBECCA

PROJECT_TERMS: Address;African American;Baseline Surveys;black patient;Black Populations;Black race;Cancer Control;cancer genetics;cancer health disparity;cancer risk;Caring;Clinical;Clinical assessments;clinical care;clinical decision-making;clinical encounter;clinical risk;Code;Communication;Communities;cost effective;Counseling;COVID-19;Data;Discrimination;Disparity;Educational process of instructing;Empirical Research;empowerment;experience;Frequencies;Gender Identity;General Population;Genetic Counseling;genetic counselor;genetic predictors;genetic testing;Genetic testing for cancer risk;Goals;Guidelines;health care disparity;Healthcare;Hereditary Malignant Neoplasm;improved;Individual;Instruction;Interview;Lesbian Gay Bisexual Transgender Queer;Link;Malignant Breast Neoplasm;Malignant neoplasm of prostate;Malignant Neoplasms;Medical;microaggression;Minority;minority patient;Modality;Multicenter Studies;Nature;non-heterosexual;Observational Study;Outcome;pandemic disease;Parents;Patient Care;patient population;patient response;Patient Self-Report;patient-clinician communication;Patient-Focused Outcomes;Patients;Perception;Personal Satisfaction;Persons;Play;Prejudice;Prevalence;prevent;Prevention;Professional counselor;programs;Provider;provider factors;Publications;Race;racial bias;racial disparity;racial population;racial prejudice;Recommendation;Reporting;Research;Research Design;Research Methodology;Research Personnel;Risk Management;Role;Sampling;satisfaction;secondary analysis;sex;Sex Orientation;Stereotyping;Surveys;telehealth;Testing;testing uptake;Therapeutic;Training;Training Programs;transgender;Trust;Video Recording

PROJECT_TITLE: Understanding the Nature and Impact of LGBTQ+ Microaggressions in Cancer Genetic Counseling Encounters

STUDY_SECTION: HHD

STUDY_SECTION_NAME: Healthcare and Health Disparities Study Section[HHD]


ADMINISTERING_IC: DK

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Digestive Diseases

ORG_CITY: SAN FRANCISCO

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: Project Narrative This application is for support of three training positions in an established program in digestive diseases that has been funded since 1975 at the Division of Gastroenterology, University of California, San Francisco. The Program’s goal is preparing trainees for careers in academic luminal gastroenterology, and its track record in this regard is outstanding, with numerous graduates of the program now in leadership positions. These talented individuals are well poised to capitalize on the exciting state of GI related research, with its transformative and translational potential.

PI_NAMEs: MA, AVERIL I (contact)

PROGRAM_OFFICER_NAME: SERRANO, KATRINA JANE

PROJECT_TERMS: Gastroenterology;Grant;Training

PROJECT_TITLE: INRSA Training Grant in Gastroenterology


ADMINISTERING_IC: HS

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Substantial variation in radiologist rates of recommendations for additional imaging and in referring provider agreement appears to lead to disparities in care and diagnostic error. If effective, this study will serve as a model for the development and audited implementation of best practices that reduce variation, diagnostic error, and disparities in medical imaging care. Our approach could be implemented in any setting using our best practices, other groups’ best practices, or national society guidelines.

PI_NAMEs: GUENETTE, JEFFREY P (contact)

PROGRAM_OFFICER_NAME: IGNACZAK, AARTEE

PROJECT_TITLE: Addressing Variability and Inequities via Systematic Evidence-based Recommendations (AdVISER) for Head and Neck Imaging

STUDY_SECTION: HSQR

STUDY_SECTION_NAME: Healthcare Patient Safety and Quality Improvement Research[HSQR]


ADMINISTERING_IC: MH

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Mental Health;Pediatric;Prevention;Suicide;Violence Research;Youth Violence

ORG_CITY: RESEARCH TRIANGLE PARK

ORG_NAME: RESEARCH TRIANGLE INSTITUTE

ORG_STATE: NC

PHR: PROJECT NARRATIVE This research is one of the first steps to understanding how and when self-injurious thoughts and behaviors (STBs) emerge in young children during middle childhood. Findings will help identify potential risk factors and mechanisms that may serve as targets for preventing STBs earlier in development before the adolescent period. Findings will set the stage for future research studies aimed at carefully understanding developmental pathways toward STB risk from childhood through adolescence.

PI_NAMEs: MILLER, ADAM BRYANT (contact);OPPENHEIMER, CAROLINE

PROGRAM_OFFICER_NAME: KING, ERIN MICHELE

PROJECT_TERMS: 7 year old;Adolescence;Adolescent;Adolescent Risk Behavior;Adult;Age;aged;Aggressive behavior;Behavior;behavior measurement;behavior prediction;biological sex;Caregivers;Catchment Area;Cessation of life;Child;Childhood;Clinical;Communities;critical period;Data;Development;diaries;Emotional;Enrollment;Event;experience;Exposure to;Feeling suicidal;Female;follow up assessment;Future;Goals;Grain;Home;Intervention;Interview;life span;Link;Measurement;Mediation;Mental disorders;Methods;middle childhood;Modeling;multimodality;National Institute of Mental Health;non-suicidal self injury;Nursery Schools;Parents;Pathway interactions;peer;Physiological;preadolescence;prevent;Prevention;Process;prospective;psychologic;Psychopathology;Questionnaires;Race;racial difference;racial diversity;Recording of previous events;Recurrence;Research;research study;respiratory;response;Risk;Risk Behaviors;Risk Factors;Sampling;School-Age Population;Self-Injurious Behavior;sex;Sex Differences;Sinus;social;stressor;suicidal morbidity;suicidal risk;Suicide;Suicide attempt;suicide rate;Testing;theories;Thinking;Time;Translation Process;Work;Youth

PROJECT_TITLE: Longitudinal examination of emotional reactivity and reactive aggression linking threat exposure with childhood self-injurious thoughts and behaviors

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


ADMINISTERING_IC: PS

IC_NAME: NATIONAL CENTER FOR HIV, VIRAL HEPATITIS, STD AND TB PREVENTION

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PI_NAMEs: KARVER, TAHILIN SANCHEZ (contact)

PROJECT_TITLE: Sailing PrEP: Tailoring PrEP navigation for sexual and gender minorities in Puerto Rico

STUDY_SECTION_NAME: Special Emphasis Panel[ZPS1 SPE (60)]


ADMINISTERING_IC: DA

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Brain Disorders;Data Science;Drug Abuse (NIDA only);Networking and Information Technology R&D (NITRD);Substance Misuse

ORG_CITY: LOWELL

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF MASSACHUSETTS LOWELL

PHR: Project Narrative: The University of Massachusetts Lowell, through its proposal Enhancing Opportunities for Addiction Research in the Merrimack Valley, will provide undergraduates with foundational training in addiction research and data sciences along with opportunities for mentored research.

PI_NAMEs: BERLOWITZ, DAN R. (contact)

PROGRAM_OFFICER_NAME: KURAMOTO-CRAWFORD, SATOKO JANET

PROJECT_TERMS: Academic Training;addiction;Address;Artificial Intelligence;Big Data;Boston;Communities;community college;community organizations;Data Analytics;Data Science;data science education;Diverse Workforce;Drug Addiction;Engineering;Ensure;equity, diversity, and inclusion;ethnic diversity;experience;Foundations;Funding;Goals;Government Agencies;Health;health information technology;Health Technology;high school;Hospitals;improved;Internships;interoperability;Investments;Knowledge;Learning;Massachusetts;medical schools;Medicine;Mentors;minority communities;Minority-Serving Institution;National Institute of Drug Abuse;Positioning Attribute;programs;Public Health Informatics;racial disparity;racial diversity;Racial Equity;racism;recruit;Reporting;Research;Research Personnel;Resources;Science;Scientist;Site;skills;Societies;STEM career;Strategic Planning;Students;success;Support System;Systematic Bias;Talents;Techniques;Technology;tool;Training;training opportunity;undergraduate education;undergraduate student;United States Department of Veterans Affairs;United States National Academy of Sciences;United States National Institutes of Health;Universities;Work;Workforce Development

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 SXC-N (A1)]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Genetics;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: EDINBURG

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF TEXAS RIO GRANDE VALLEY

ORG_STATE: TX

PHR: Alzheimer´s disease (AD) disproportionately impacts Hispanics/Latinos residing in the US, but the reasons are unknown. The physical and social features of living environments – the neighborhood or el barrio for Mexican Americans – likely influence the relationship between the aging process and individuals' cognitive trajectories but dissecting such contextual versus individual effects upon risk of Alzheimer´s disease (AD) is a complex problem. To overcome this knowledge gap, this project aims to determine the effects of neighborhood on AD-like cognitive trajectories in Mexican Americans, by a novel approach that integrates 1) individual differences revealed by high-dimensional -omics data and 2) mediation by family and el barrio dynamics; together yielding new evidence to assist neighborhood and city planners and policymakers to improve outcomes in this fastest-growing elderly population in the U.S.

PI_NAMEs: MAESTRE, GLADYS E. (contact)

PROGRAM_OFFICER_NAME: NGUYEN, EMERALD THAI HAN

PROJECT_TERMS: Affect;Age;aging process;Alzheimer's Disease;Alzheimer's disease risk;Biological Markers;built environment;cardiometabolism;Caucasians;Characteristics;Cities;Clinical;Cognitive;cohort;Communication;Complex;Data;Disparity;Elderly;Elements;Environment;epigenomics;Family;Family Study;Genetic;Genetic Transcription;genome sequencing;Goals;Health;high dimensionality;Hispanic Americans;Hispanic Populations;Imagery;Impaired cognition;improved outcome;Individual;Individual Differences;insight;Knowledge;Latino Population;Link;lipidomics;Mediation;Metabolic;metabolic profile;metabolomics;Mexican Americans;molecular marker;multiple omics;Neighborhoods;neuroimaging;novel strategies;older adult;Participant;Pathway interactions;Pattern;Policy Maker;Population;protein expression;Research;Signal Transduction;social;Social Environment;Testing;transcriptomics;Variant;whole genome

PROJECT_TITLE: Integration of Socio-Spatial Data for Neighborhoods with Multi-omic profiles to Identify and Mitigate Factors Affecting Risk of ALzheimer's Disease


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PHR: The long-term vision of this LEADR proposal is to erase racial disparities in Alzheimer’s disease/Alzheimer’s disease related dementias (AD/ADRD) prevalence and burden. In this project, we will 1) develop a measure of structural discrimination and resilience, 2) use it to predict outcomes in AD/ADRD and 3) develop interventions to decrease prevalence and increase resilience. This program of work will move beyond individual and family interventions to address the structural determinants of AD/ADRD.

PI_NAMEs: SZANTON, SARAH L (contact)

PROGRAM_OFFICER_NAME: BANDIERA, FRANK

PROJECT_TERMS: Address;Advocate;African American population;Alzheimer's Disease;Alzheimer's disease related dementia;Black race;Brain;Caring;cognitive testing;Communities;Compensation;Coping Skills;Data;Data Collection;Data Set;dementia burden;design;Dimensions;Discrimination;Disease;Disparity;Environment;Family;family support;Funding;Goals;Green space;Heart Diseases;high reward;high risk;Home;Hypertension;Individual;Inflammatory;innovation;insight;instrument;Intervention;Investments;life span;Measurement;Measures;Methods;model design;older adult;outcome prediction;Pathway interactions;Persons;Phase;pilot test;Policies;Policy Maker;Population;Prevalence;Prevention;Process;programs;promote resilience;protective factors;racial discrimination;racial disparity;Research;Research Personnel;resilience;Resources;Risk Factors;Role;school district;Side;social;Societies;Stroke;structural determinants;Taxes;Testing;therapy development;Toxic Environmental Substances;United States National Institutes of Health;Work

PROJECT_TITLE: Reducing racial disparities in AD/ADRD: Addressing structural discrimination and resilience


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Brain Disorders;Data Science;Drug Abuse (NIDA only);Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Substance Misuse

ORG_CITY: FORT WORTH

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF NORTH TEXAS HLTH SCI CTR

PHR: PROJECT NARRATIVE. This project introduces an innovative approach to research education for early career addiction researchers, immersing them in artificial intelligence and statistical machine learning. The goal is to elevate their research capabilities in navigating the vast landscapes of big data, real-world data, data science, and open science by embracing the future of addiction science with cutting-edge technologies.

PI_NAMEs: MUN, EUN-YOUNG  (contact)

PROJECT_TERMS: Acceleration;addiction;Address;Affect;aged;Alcohol consumption;Alcohols;Algorithms;Artificial Intelligence;base;Behavior;Big Data;burden of illness;career;career networking;Clinical Investigator;Clinical Research;Cloud Computing;Code;cohort;Computer software;Data;Data Science;Data Set;data sharing;deep learning;Development;diverse data;Doctor of Philosophy;drinking;Drug usage;E-learning;education research;Educational Curriculum;Educational Grants;Electronic Mail;empowerment;Environment;epidemiology study;Evolution;experience;Faculty;FAIR principles;Fostering;Future;Genetic;Goals;Grant;hands on research;Health;health equity;Health Sciences;help-seeking behavior;high dimensionality;improved;Individual;innovation;Institution;Intervention;Intervention Trial;Knowledge;Learning Module;Learning Skill;machine learning method;Measures;Mentors;Methods;mHealth;Monitor;National Institute of Drug Abuse;Neurosciences;next generation;novel;online course;open data;Outcome;Outcomes Research;Paper;Participant;post-doctoral training;Postdoctoral Fellow;pre-doctoral;pre-trained transformer;Prevention Research;Principal Investigator;Prize;Program Effectiveness;programs;Publications;Pythons;recruit;Reproducibility;Research;Research Ethics;Research Personnel;response;Risk;risk mitigation;Science;Series;social media;social stigma;Societies;Speed;statistical and machine learning;Statistical Models;statistics;substance use;success;Surveys;symposium;Techniques;Technology;Texas;tool;Training;Training Programs;treatment trial;United States National Institutes of Health;United States Substance Abuse and Mental Health Services Administration;Universities;Washington;web site

PROJECT_TITLE: Preparing the Next Generation of Addiction Researchers in Computational AI/ML Techniques


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cancer;Clinical Research;Dementia;Genetics;Neurodegenerative;Prevention

ORG_CITY: HOUSTON

ORG_DEPT: GENETICS

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: Public Health Relevance Statement In this project, it is proposed that an important class of proteins exists universally in all organisms, that prevents damage to molecules, and that, in humans, these proteins constitute natural cancer- and neurodegenerative disease-prevention proteins. These protection proteins and their genes were not hypothesized or identified previously, in part because of inadequate genetic methods for finding and understanding them. The project includes—use of new methods capable of finding and defining the functions of these proteins; the development of new technology for increasing production of any specific natural protein to act as a drug for prevention of cancer and other age-related maladies; and creation of a simple blood-pressure- like general technology for pre-disease and early diagnosis of individuals who need these protection-protein therapies, at risk for cancer, neurodegenerative, Alzheimer, and many other diseases.

PI_NAMEs: ROSENBERG, SUSAN M (contact)

PROGRAM_OFFICER_NAME: PETANCESKA, SUZANA

PROJECT_TERMS: AD transgenic mice;Age;age related;age-related disease;Aging;Alzheimer disease detection;Alzheimer disease screening;Alzheimer's Disease;Amino Acids;Antisense Oligonucleotides;Award;Bacterial Model;base;Benign;Biological Assay;Biological Markers;Biology;Blood;Blood Pressure;Cancer Model;cancer prevention;cancer risk;Cells;Charge;Clinical Trials;Computer software;Cytoprotection;Data;Desiccation;design;Development;Diagnostic;Disease;disease diagnosis;disease model;Disease Progression;Disease Resistance;disorder prevention;DNA;DNA Damage;DNA Sequence Alteration;Drug Metabolic Detoxication;Drug Screening;Early Diagnosis;Environment;Escherichia coli;Escherichia coli Proteins;Expression Library;Freedom;Genes;Genetic;Genome;Genomic Instability;Goals;Health Promotion;Heat shock proteins;Heat-Shock Proteins 90;Human;improved;Individual;inhibitor;Insecta;Leukocytes;Lipids;macromolecule;Malignant Neoplasms;Measures;Medical;Medicine;Methods;misfolded protein;model organism;Modeling;Molecular;Molecular Chaperones;mRNA Translation;Mus;Mutagenesis;Mutation;Nerve Degeneration;Neurodegenerative Disorders;new technology;Normal Cell;Organism;overexpression;Pathogenesis;Pathway interactions;Pharmaceutical Preparations;pharmacologic;Plants;prevent;Prevention;Production;Property;protein function;Proteins;Proteome;proteostasis;proteotoxicity;public health relevance;Quality Control;Resistance;sex;Specificity;Stress;success;System;Technology;Testing;Transfection;Up-Regulation;Work

PROJECT_TITLE: Harnessing Proteins as Drugs: the Protectome of Cancer- and Aging-Prevention Proteins


ADMINISTERING_IC: OD

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

FUNDING_MECHANISM: CONSTRUCTION GRANTS

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

ORG_CITY: AMHERST

ORG_DEPT: DENTISTRY

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

ORG_STATE: NY

PI_NAMEs: KIRKWOOD, KEITH L (contact)

PROGRAM_OFFICER_NAME: CHEN, YONG

PROJECT_TERMS: Animal Experimentation;Animal Model;Animals;Architecture;Cardiovascular Diseases;career;Colon Carcinoma;Complex;Comprehensive Cancer Center;Consultations;design;Direct Costs;Disease;disease phenotype;Education;Ensure;Environment;Epidemiology;experience;Facility Design and Construction;Funding;Germ-Free;Gnotobiotic;Goals;Health;Home;Human;Human body;Human Microbiome;Inflammatory Bowel Diseases;Infrastructure;Laboratories;Laboratory Animal Production and Facilities;Laboratory Animals;Laboratory Research;Metabolic Diseases;microbial community;microbiome;microbiome research;microbiota;microorganism;Modeling;Mus;New York;New York City;next generation;Oral cavity;oral microbiome;Osteoporosis;Pathology;Phase;Primates;programs;Research;Research Personnel;Research Project Grants;Science;Scientist;Services;Signal Transduction;square foot;Systemic disease;Technology;Testing;Training;United States National Institutes of Health;Universities

PROJECT_TITLE: UB Microbiome Center Gnotobiotic Animal Research Facility

STUDY_SECTION: STOD

STUDY_SECTION_NAME: Scientific and Technical Review Board on Biomedical and Behavioral Research Facilities[STOD]


ADMINISTERING_IC: HL

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

PHR: Project Narrative Down syndrome (DS) is the most common genetic form of intellectual disability and is associated with an increased risk for many adverse health outcomes, including structural heart defects, sleep apnea, thyroid abnormalities, hearing and vision problems, and early-onset dementia. NIH’s INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE (INCLUDE) Project is funding a broad effort to collect data from a large group of people with DS across a range of ages and backgrounds to help researchers understand why individuals with DS are more likely to have these conditions, which will help guide treatments and interventions to improve their health and well-being. The INCLUDE Clinical Cohort Coordinating Center will play an important role in this effort by working with cohort collection sites to capture data from a wide range of health conditions and make sure these data are submitted to the INCLUDE Data Coordinating Center, where it will be accessible for researchers.

PI_NAMEs: HUNTER, JESSICA EZZELL (contact);ROSSER, TRACIE C

PROGRAM_OFFICER_NAME: SCHRAMM, CHARLENE A

PROJECT_TERMS: Adult;Advocate;Affect;Age;Area;Awareness;biobank;Child;Clinical;cohort;Collaborations;Collection;Common Data Element;Communication;Communication Programs;Communities;community engagement;comorbidity;Complex;Consensus;Custom;Data;Data Analyses;Data Collection;Data Coordinating Center;data exchange;data harmonization;data hub;data management;Data Management Resources;data pipeline;data quality;data resource;Data Storage and Retrieval;data submission;Decision Making;Dedications;Dementia;Development;digital health;Down's Syndrome;early onset;Ecosystem;Enrollment;Ensure;Etiology;Evidence based intervention;experience;Family;Fostering;Funding;Future;Generations;Genetic;Goals;Health;health equity;Hearing;Human Resources;improved;Individual;Infrastructure;innovation;Institution;Intellectual functioning disability;International;Intervention;Investigation;Knowledge;Lead;Leadership;life span;meetings;member;Mission;Office of Administrative Management;open data;operation;Outcome;Outcome Measure;outreach;Participant;Patient Recruitments;Patients;Performance;Personal Satisfaction;Persons;Phenotype;phenotypic data;Play;Principal Investigator;Process;Program Development;programs;protocol development;Protocols documentation;Recording of previous events;recruit;Research;Research Personnel;research study;Resource Sharing;Resources;Risk;Role;Scientific Advances and Accomplishments;Secure;Site;Sleep Apnea Syndromes;structural heart disease;Structure;success;synergism;System;Technology;Thyroid Gland;Time;tool;Underrepresented Populations;United States National Institutes of Health;Universities;virtual;Vision;Work;working group

PROJECT_TITLE: INCLUDE Down Syndrome Clinical Cohort Coordinating Center (DS-4C)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IVBH-A (56)]


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Down Syndrome;Intellectual and Developmental Disabilities (IDD)

PI_NAMEs: HUNTER, JESSICA EZZELL (contact)

PROJECT_TERMS: Affect;Agreement;Area;Awareness;biobank;Clinical;cohort;Collaborations;Collection;Communication;Communities;community engagement;comorbidity;Complex;Consent;Data;data acquisition;Data Collection;Data Coordinating Center;data exchange;data harmonization;data hub;data management;data quality;data sharing;design;Development;dissemination strategy;Down's Syndrome;Ecosystem;Effectiveness;empowerment;Enrollment;Ensure;Evaluation;experience;flexibility;follow-up;Fostering;Funding;Goals;Health;health equity;improved;Individual;Information Dissemination;Infrastructure;International;Investigation;Language;Lead;Leadership;life span;Logistics;meetings;member;Mission;Monitor;Observational Study;operation;Outcome;outreach;Participant;Patient Recruitments;payment;Personal Satisfaction;Persons;Phenotype;phenotypic data;Principal Investigator;Privatization;Procedures;Process;Productivity;Program Development;programs;protocol development;Protocols documentation;Publications;Qualifying;quality assurance;Recording of previous events;recruit;remediation;Reporting;Research;Research Personnel;Resolution;Resources;Schedule;Science;Secure;Site;Solid;Structure;success;symposium;System;Time;tool;tool development;Training;trend;Underrepresented Populations;United States National Institutes of Health;Universities;Vision;Visit;web portal;web-based tool;webinar;Work

PROJECT_TITLE: Down Syndrome Clinical Cohort Coordinating Center (DS-4C) for the INCLUDE Project


PI_NAMEs: ALLEN, EMILY GRAVES (contact)

PROJECT_TERMS: Advocacy;Affect;Awareness;biobank;Clinical;cohort;Collaborations;Collection;Communication;Communities;community engaged research;community engagement;Community Outreach;community partnership;comorbidity;Complex;cost;Data;Data Collection;Data Coordinating Center;data exchange;data harmonization;data hub;data management;design;Development;diversity and inclusion;Down's Syndrome;Ecosystem;Education and Outreach;Ensure;Equity;Event;experience;Family;family burden;Fostering;Friends;Genetic Counseling;Goals;graduate student;Health;health equity;health equity promotion;Human Resources;improved;Incentives;Individual;innovative technologies;insight;International;Investigation;Investments;Knowledge;Leadership;life span;Medical;meetings;member;Methods;Mission;Monitor;Outcome;outreach;Participant;Patient Recruitments;Personal Satisfaction;Personnel Recruitments;Phenotype;phenotypic data;Population;Population Heterogeneity;Principal Investigator;Productivity;Program Development;programs;protocol development;Protocols documentation;Recording of previous events;recruit;Recruitment Activity;Research;Research Personnel;Research Project Grants;Resources;Science;Site;skills;Spanish;Structure;success;System;Test Result;tool;Training;Training Programs;undergraduate student;Underrepresented Populations;Underserved Population;Universities;web portal;Work


PI_NAMEs: ROSSER, TRACIE C (contact)

PROJECT_TERMS: Address;Affect;Ancillary Study;Awareness;Back;biobank;Clinical;cohort;Collaborations;Collection;Communication;Communities;community engagement;comorbidity;Complex;dashboard;Data;data acquisition;Data Collection;Data Coordinating Center;Data Element;data exchange;data harmonization;data hub;data management;Data Management Resources;data standards;data submission;design;Development;Devices;digital health;Documentation;Down's Syndrome;Ecosystem;Electronic Health Record;Emerging Technologies;Enrollment;Ensure;experience;Fostering;Generations;Goals;Guidelines;Health;health equity;Housing;improved;Individual;Infrastructure;interest;International;Investigation;Lead;Leadership;life span;Measures;meetings;member;Methods;Mission;Monitor;novel strategies;Outcome;outreach;Participant;Patient Recruitments;Personal Satisfaction;Phenotype;phenotypic data;Principal Investigator;Privatization;Procedures;Program Development;programs;protocol development;Protocols documentation;Quality Control;Recording of previous events;recruit;Reference Document;Reporting;Reproducibility;Research;Research Personnel;Resources;sample collection;Science;Site;Structure;System;tool;Training;Underrepresented Populations;Universities;Validation;web portal;Work


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Data Science;Down Syndrome;Intellectual and Developmental Disabilities (IDD);Networking and Information Technology R&D (NITRD)

PI_NAMEs: AUMAN, JEANETTE O'DONNELL (contact)

PROJECT_TERMS: Affect;Awareness;biobank;Clinical;cloud based;cohort;Collaborations;Collection;Communication;Communities;community engagement;comorbidity;Complex;complex data;Computer software;Data;Data Collection;Data Coordinating Center;data de-identification;data exchange;data harmonization;data hub;data ingestion;data integration;data management;data quality;Data Set;data sharing;data standards;Development;digital health;Down's Syndrome;Electronic Health Record;Ensure;experience;Fostering;Genomics;Goals;Health;health equity;Image;improved;Individual;Informatics;Ingestion;Institution;International;Investigation;Laboratories;Leadership;life span;Measures;member;Mission;Outcome;outreach;Parents;Participant;participant enrollment;Patient Recruitments;Personal Satisfaction;Phenotype;phenotypic data;Preparation;Principal Investigator;Process;Program Development;programs;protocol development;Protocols documentation;Quality Control;Quality Indicator;Recording of previous events;recruit;Reporting;Research;Research Personnel;Resolution;Resources;Secure;Site;Software Tools;Standardization;Structure;Surveys;System;Systems Development;Technical Expertise;technology platform;Time;tool;Underrepresented Populations;Universities;Work


ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PI_NAMEs: SULLIVAN, NANCY JEAN (contact)

PROJECT_TERMS: 2019-nCoV;Academic Medical Centers;Air;Air Pressure;Animal Model;Animals;Area;Arthropod Vectors;Arthropods;biodefense;biosecurity;Boston;Certification;clinical diagnostics;Containment;Decontamination;design;Development;Diagnostic;Disease;Emerging Communicable Diseases;flexibility;Frequencies;Future;Future Generations;Goals;high efficiency particulate air filter;Housing;Human;human disease;human model;improved;Individual;Infectious Diseases Research;Infrastructure;Laboratories;Maintenance;medical countermeasure;Modernization;new pandemic;Operations Research;pandemic pathogen;pandemic potential;pathogen;Phase;pressure;Process;Productivity;programs;Research;research facility;Research Personnel;Research Priority;Risk;Scientist;System;Therapeutic;Ticks;Time;Training;transmission process;United States National Institutes of Health;Universities;Update;vaccine development;vector;vector mosquito;Work

PROJECT_TITLE: Modernization of high and maximum containment research facilities at the National Emerging Infectious Diseases Laboratories (NEIDL) to meet current and future national research priorities


ADMINISTERING_IC: AI

ED_INST_TYPE: OVERALL MEDICAL

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Clinical Research;Digestive Diseases;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: COLLEGE STATION

ORG_DEPT: BIOLOGY

ORG_NAME: TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR

PHR: Project Narrative The proposed research is relevant to public health because understanding how to best use vancomycin to treat C. difficile infection is likely to improve patient outcomes, thus ensuring continued success with this important treatment option of the most common healthcare- associated infection. This proposal is relevant to the part of NIH’s mission that pertains to fostering fundamental creative discoveries and innovative research strategies as a basis for ultimately protecting health.

PI_NAMEs: GAREY, KEVIN W;HURDLE, JULIAN G (contact)

PROGRAM_OFFICER_NAME: RANALLO, RYAN

PROJECT_TERMS: Address;Affect;Animal Model;Antibiotic Resistance;Antibiotics;Antimicrobial Resistance;Bacteria;biobank;Biological Assay;Cells;Cessation of life;Characteristics;Clinical;Clinical Microbiology;Clinical Research;Clinical Trials;clinically relevant;Clostridium difficile;Colon;Creativeness;Development;Diagnostic;Disease;emerging pathogen;Ensure;Epidemic;epidemiology study;Evolution;Failure;Fluoroquinolones;Fostering;Foundations;genetic signature;Genetic Variation;Genome;genome analysis;Genomics;Gentian Violet;Goals;Grouping;gut microbiome;Health protection;healthcare-associated infections;Hospitalization;Hospitals;improved;In Vitro;Infection;innovation;International;Investigation;Laboratories;Measures;Metadata;Methods;Metronidazole;Metronidazole resistance;Microbial Biofilms;Mission;Modeling;Molecular;Morbidity - disease rate;mortality;Organism;Outcome;Outcomes Research;parent grant;Patient Isolation;Patient-Focused Outcomes;Patients;Pattern;Pharmaceutical Preparations;polymicrobial biofilm;population based;Predisposition;pressure;Prevalence;Production;Public Health;rapid detection;Recurrence;recurrent infection;Reporting;Research;Research Project Grants;Resistance;Resistance development;resistance mechanism;resistant strain;response;Ribotypes;Risk;Sampling;secondary endpoint;Severity of illness;success;Techniques;Testing;Therapeutic;Time;tool;Translational Research;transmission process;Treatment Failure;United States;United States National Institutes of Health;Vancomycin;Vancomycin Resistance

PROJECT_TITLE: Decoding the clinical impact of the recent evolution of metronidazole resistance on Clostridium difficile infection.


ADMINISTERING_IC: EB

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: CLEMSON

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: CLEMSON UNIVERSITY

ORG_STATE: SC

PHR: Project Narrative This proposal will investigate the ethical question of how user perceptions, technology acceptance, and health effects of wearable robotics technologies, such as back-support exoskeletons, differ across sex and race. In the long term, this study will enhance and broaden our understanding of expectations and concerns regarding the design and use of exoskeletons among diverse demographic groups and document the ethical concerns arising from currently limited participant representation in exoskeleton design evaluations.

PI_NAMEs: SRINIVASAN, DIVYA  (contact)

PROGRAM_OFFICER_NAME: BITTMANN, MORIA FISHER

PROJECT_TERMS: Address;Adoption;Adult;adverse outcome;Affect;Age;Anthropometry;Articular Range of Motion;Automobile Driving;Back;Back Injuries;biomechanical test;Biomechanics;Body Regions;Characteristics;comparison control;Country;Data;Decision Trees;demographics;design;Development;Devices;Direct Costs;disability;Effectiveness;Equity;Ethics;Evaluation;Exertion;exoskeleton;expectation;experience;experimental study;Feedback;Female;Future;Health;Health Benefit;health difference;health disparity;Healthcare;Hip region structure;Human;Industrialization;Industry;Injury;Intervention;Joints;Knee;Laboratories;Literature;Low Back Pain;male;manufacture;Measures;men;Methods;Muscle;Musculoskeletal Diseases;Occupational;Outcome Study;Participant;Perception;Physical activity;Physical Performance;Predictive Factor;preference;pressure;Psychological Factors;psychosocial;Psychosocial Factor;Questionnaires;Race;racial difference;racial population;recruit;Reporting;Research;Research Design;Risk Reduction;robot exoskeleton;Robotics;Sampling;sex;Societies;sociocultural determinant;Standardization;stem;Technology;Testing;Textiles;usability;wearable device;Woman;Workplace;young adult

PROJECT_TITLE: Ethical Considerations in The Design and Testing of Back-Support Exoskeletons

STUDY_SECTION_NAME: Special Emphasis Panel[ZEB1 OSR-H (O1)]


ORG_CITY: BUFFALO

ORG_NAME: ROSWELL PARK CANCER INSTITUTE CORP

PI_NAMEs: AMBROSONE, CHRISTINE B. (contact)

PROJECT_TERMS: Aliquot;Automobile Driving;biobank;Biomedical Research;Blood;Blood specimen;Clinical;cold temperature;Collection;Communities;Comprehensive Cancer Center;Consumption;Data;data repository;epidemiology study;Equipment and supply inventories;Floor;Funding;Grant;Growth;Hematology;Human;Institution;Laboratories;laboratory facility;Link;Liquid substance;Malignant Neoplasms;Mission;Nitrogen;Operative Surgical Procedures;Outcome;Participant;Pathology;peripheral blood;prevent;Procedures;Process;Research;Resource Sharing;Resources;Retrieval;Robotics;Sampling;Science;Services;Standardization;System;Time;Tumor Tissue;United States National Institutes of Health;Vision

PROJECT_TITLE: ONE Biorepository: Comprehensive Integrated Biobanking Systems


ORG_CITY: WORCESTER

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PI_NAMEs: KORNFELD, HARDY  (contact)

PROJECT_TERMS: 2019-nCoV;Address;Alpha Virus;Award;Basic Science;bench-to-bedside translation;Biological Response Modifier Therapy;Biotechnology;Clinical Research;clinical research site;Clinical Trials;COVID-19 pandemic;Dedications;Drug resistance;emerging pathogen;Equipment;Faculty;Floor;Foundations;Funding;Image;In Vitro;in vivo;Infectious Diseases Research;Institution;International;Laboratories;Massachusetts;medical schools;Mycobacterium tuberculosis;novel;pandemic disease;pandemic potential;pandemic virus;pathogen;pathogenic bacteria;pathogenic virus;Patients;Positioning Attribute;Prevention;Privatization;Productivity;programs;Research;Research Institute;Research Personnel;research study;resilience;Risk;Safety;Sampling;Therapeutic;therapeutic RNA;therapy development;Translating;Translational Research;United States National Institutes of Health;Universities;University resources;Vaccine Therapy;Viral Hemorrhagic Fevers;Virus;Yersinia pestis

PROJECT_TITLE: A Biosafety Level 3 Laboratory for Viral Pathogens


ADMINISTERING_IC: VA

FUNDING_MECHANISM: OTHERS

IC_NAME: Veterans Affairs

ORG_CITY: GAINESVILLE

ORG_NAME: VETERANS HEALTH ADMINISTRATION

ORG_STATE: FL

PHR: Noninvasive imaging tests, including computed tomography (CT), magnetic resonance imaging (MRI), and nuclear medicine are performed millions of times every year in the United State. An estimated 20-30% of these tests do not benefit the patient and are considered inappropriate. Most of these tests involve radiation, which is imparts a small risk of future cancer. Inappropriate tests may delay or limit access to patients with appropriate indications for testing. Reducing inappropriate testing could reduce costs and make funds available for other Veteran services. In this award, we propose a series of investigations to better understand why inappropriate tests are ordered, what the cost is to the VA system, and implement a system to reduce inappropriate tests. Veterans will directly benefit from this research through reduction in wait times and avoiding harm from radiation; indirectly the VA health system will benefit from cost avoidance.

PI_NAMEs: WINCHESTER, DAVID E (contact)

PROJECT_TERMS: Address;administrative database;Adopted;Adoption;Adverse effects;Attention;Award;Blinded;Capital;Cardiology;care delivery;career;Caring;Clinical;Computer software;Computerized Patient Records;cost;Cost Savings;Costs and Benefits;Data;data streams;Diagnostic;Diagnostic Imaging;Diagnostic radiologic examination;Diagnostic tests;diaries;Direct Costs;Discipline of Nuclear Medicine;Echocardiography;Effectiveness;effectiveness evaluation;effectiveness measure;Electronics;empowerment;experience;Feedback;Funding;Future;Glean;Goals;Habits;health care delivery;Health Services;Health Services Accessibility;Health system;human capital;Image;implementation evaluation;implementation process;implementation science;implementation tool;improved;innovation;insight;Interview;Investigation;Investigator-Initiated Research;Investments;Leadership;Learning;Literature;Magnetic Resonance Imaging;Malignant Neoplasms;Measures;Medical center;Medical Societies;Methods;microcosting;Modality;Modeling;Motion;non-invasive imaging;noninvasive diagnosis;Odds Ratio;Patient Care;Patients;payment;point of care;Practical Robust Implementation and Sustainability Model;primary outcome;Process;Program Reviews;programs;Provider;Radiation;radiation risk;Radiology Specialty;Reporting;Research;research clinical testing;Research Personnel;Research Project Grants;Risk;Series;Services;Single-Payer System;Strategic Planning;Structure;support tools;Surveys;System;Testing;Theoretical Domains framework;Time;Translating;ultrasound;United States;United States Department of Veterans Affairs;Veterans;Veterans Health Administration;Wait Time;X-Ray Computed Tomography

PROJECT_TITLE: Strategies to Reduce Unnecessary Noninvasive Imaging

STUDY_SECTION_NAME: HSR&D Career Development Award [CDA0]


ORG_CITY: PORTLAND

ORG_NAME: PORTLAND VA MEDICAL CENTER

ORG_STATE: OR

PHR: Traumatic brain injury (TBI) is a major cause of disability in the Veteran population, often resulting in chronic pain and sleep disturbances, among other sequela. Extensive rehabilitative efforts are usually required and often prevent return to the workforce and community. Disturbed sleep and excessive daytime sleepiness are among the most pervasive and enduring sequelae after TBI, which we hypothesize is a significant contributor to these functional impairments and an impediment toward rehabilitation. Thus, our research aims to enhance sleep quality as a means to reduce pain and improve quality of life and functional outcome measures in Veterans with TBI. We predict that the proposed intervention, morning bright light therapy, if found effective, will be cost-effective, rapidly deployable, and highly accepted by Veterans with TBI.

PI_NAMEs: ELLIOTT, JONATHAN E (contact)

PROJECT_TERMS: actigraphy;Adverse effects;Caring;Categories;Chronic;chronic pain;chronic pain management;Circadian Rhythm Sleep Disorders;Communities;conditioned pain modulation;cost effective;Data;Dedications;design;Development;Diffuse;disability;economic impact;effective therapy;Effectiveness;Excessive Daytime Sleepiness;Feasibility Studies;follow-up;Functional impairment;functional outcomes;Future;General Population;Headache;Healthcare Systems;Home;Impairment;improved;improvement on sleep;indexing;Individual;innovation;Intervention;Light;Literature;Measures;Meta-Analysis;Methods;mild traumatic brain injury;military veteran;Monitor;Nonpharmacologic Therapy;Outcome;Outcome Measure;Overdose;Pain;Pain intensity;Pain interference;pain reduction;Pain Threshold;Pathogenesis;Patient Self-Report;Persons;pharmacologic;Phototherapy;Population;post intervention;prescription opioid addiction;pressure;Prevalence;prevent;primary outcome;Protocols documentation;Public Health;Publishing;Quality of life;Questionnaires;Randomized;Recording of previous events;recruit;Rehabilitation therapy;Reporting;Research;Severities;Sleep;Sleep disturbances;sleep quality;Sleeplessness;Testing;Time;Training;Traumatic Brain Injury;Treatment Effectiveness;United States National Institutes of Health;Veterans;Work;World Health Organization Disability Assessment Schedule

PROJECT_TITLE: A Sleep Intervention to Improve Rehabilitation in Veterans with Chronic mTBI

STUDY_SECTION_NAME: Career Development Program - Panel II[RRD9]


ADMINISTERING_IC: DE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Dental, Oral, and Craniofacial Disease;Neurosciences

ORG_CITY: SALT LAKE CITY

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Project Narrative: Magnetic resonance-guided focused ultrasound (MRgFUS) is a promising non-invasive treatment modality being investigated for various disorders. For these treatments to be safe and effective, the acoustic energy must be precisely delivered to the affected tissues. This project aims to improve the accuracy of transcranial acoustic modeling, which will enable better-individualized treatments. The results could remove a significant technical limitation, extending the current therapeutic ultrasound applications of mechanical and thermal ablation and paving the way for novel applications, such as blood-brain barrier opening and neuromodulation.

PI_NAMEs: CLINARD, SAM  (contact)

PROGRAM_OFFICER_NAME: FUQUA, CHANTEL FAYSAN

PROJECT_TERMS: Ablation;Acoustics;Affect;Algorithms;attenuation;Bathing;Black Box;Blood - brain barrier anatomy;bone;Cell Nucleus;Cephalic;Characteristics;Clinical;Clinical Data;Compensation;Complex;Computed Tomography Scanners;cost;cranium;Data;Dependence;Devices;Disease;Drug Delivery Systems;Eligibility Determination;Equation;Essential Tremor;experience;experimental study;FDA approved;Focused Ultrasound;Focused Ultrasound Therapy;Foundations;Future;Goals;Heating;High Resolution Computed Tomography;Human;Hybrids;improved;Individual;individualized medicine;Magnetic Resonance;Magnetic Resonance Imaging;Maps;Measurement;Measures;Mechanics;Mentors;Methods;Modality;Modeling;Monitor;Morbidity - disease rate;mortality;Nervous System Disorder;Neurology;neuroregulation;novel;Patients;Phase;Positioning Attribute;pressure;Procedures;Property;Research;Research Training;Safety;Sampling;Scanning;simulation;sound;Speed;Stimulus;System;Temperature;Thalamic structure;Therapeutic;Thermal Ablation Therapy;Thermometry;Tissues;transmission process;treatment duration;ultrasound;Water;Work;X-Ray Computed Tomography

PROJECT_TITLE: Acoustic Modeling of skull bone for improved transcranial MR-guided focused ultrasound therapy

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


ORG_CITY: STONY BROOK

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

PHR: Understanding diapause and its ability to suspend and preserve life Project Narrative As a natural form of “suspended animation”, diapause is a dormant state which can suspend embryonic development and preserve life for an extended time without compromising following health and life. However, our knowledge of how diapause works, especially in a more complex vertebrate system, remains limited. Here we study diapause through two complementary angles – signaling pathways and functioning mechanisms – using a naturally short-lived African killifish for its remarkable ability for staying in diapause to survive the drought for up to years.

PI_NAMEs: HU, CHI-KUO  (contact)

PROGRAM_OFFICER_NAME: FU, YI-PING

PROJECT_TERMS: Acceleration;Adult;African;Aging;animation;Cellular biology;Characteristics;Complement;Complex;Coupled;Development;Diapause;Droughts;Embryo;embryo preservation;Embryonic Development;experimental study;fascinate;fictional works;genome editing;Growth;Health;improved;Killifishes;Knowledge;Life;life span;Microscopy;Nature;new technology;novel;Organism;Physiological;Physiology;preservation;Proliferating;Quality of life;Research;Research Subjects;research vision;Resources;Science;Signal Pathway;Signal Transduction;Suspensions;System;systems research;Time;tool;Translating;Vertebrates;Vision;Work


NIH_SPENDING_CATS: Aging;Cancer

ORG_CITY: TAMPA

ORG_NAME: H. LEE MOFFITT CANCER CTR & RES INST

PHR: PROJECT NARRATIVE Globally, the population aged 65 and above is growing faster than all other age groups posing a significant problem to the healthcare system, the exponential increase of many age-related diseases; one such disease is cancer, whose risk of incidence increases 11-fold as one gets old. Despite this, and contrary to other age-related diseases such as Alzheimer’s or diabetes, cancer research currently has virtually no framework that factors in the aging process. Here, I propose a new conceptual framework to precisely map how the aging process imparts into cancer progression and to identify novel therapeutic strategies for older cancer patients that factors in the reprogramming that occur with aging.

PI_NAMEs: DA SILVA GOMES, ANA  (contact)

PROGRAM_OFFICER_NAME: GUO, MAX

PROJECT_TERMS: Affect;Age;age effect;age group;age-related disease;aged;Aging;aging process;Alzheimer's Disease;anti-cancer;anti-cancer research;anti-cancer treatment;Biological Aging;cancer cell;cancer diagnosis;Cancer Patient;cancer therapy;Cells;Clinical Trials;Data;design;Diabetes Mellitus;Disease;Evolution;FarGo;FDA approved;Genotype;guided inquiry;Healthcare Systems;Human;human old age (65+);Immunotherapy;Incidence;Infrastructure;Knowledge;Malignant Neoplasms;malignant phenotype;Maps;Metabolic;Mutagens;neglect;Neoplasm Metastasis;neoplastic cell;new therapeutic target;novel therapeutic intervention;Older Population;Organism;Outcome;Patients;Phenotype;Population;pre-clinical research;pressure;Primary Neoplasm;Prognosis;Rejuvenation;response;Risk;Risk Factors;Role;Sampling;Serum;single cell technology;Therapeutic;Therapeutic Intervention;Time;Tissues;tumor microenvironment;tumor progression;virtual

PROJECT_TITLE: AGING AS A SELECTIVE PRESSURE THAT DRIVES TUMOR PROGRESSION


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Behavioral and Social Science;Brain Disorders;Dementia;Down Syndrome;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Intellectual and Developmental Disabilities (IDD);Machine Learning and Artificial Intelligence;Social Determinants of Health

ORG_CITY: BOSTON

PHR: PROJECT NARRATIVE While lifespan has greatly expanded for people with Down syndrome (DS) in the last seventy years, the population still experiences burdensome morbidities and premature mortality. This project contributes to public health knowledge by developing the Down Syndrome: Towards Optimal Trajectories and Health Equity using Medicaid Analytic eXtract Project (DS-TO-THE-MAX), a 10-year retrospective cohort of >100,000 adults with and >4,000,000 adults without DS enrolled in Medicaid, a US public health insurance program for low income and / or disabled people. With these data, we will describe epidemiology, identify risks and social determinants, and use machine learning to identify factors that may predict occurrence or resilience of obstructive sleep apnea, dementia, and mortality in a diverse sample orders of magnitude larger than previous DS studies.

PI_NAMEs: RUBENSTEIN, ERIC S (contact)

PROJECT_TERMS: Acceleration;Achievement;Adult;Advocate;Age;Age Distribution;Age of Onset;Age Years;Algorithms;Alzheimer's Disease;American;Amyloid beta-Protein Precursor;Autopsy;Big Data;Black Populations;Black race;Cause of Death;Cessation of life;Child;Chromosome 21;Chronic;classification trees;Clinical;Clinical Research;Clinical Trials;cohort;Color;Communities;community-level factor;Complement;Congenital Heart Defects;Data;Data Set;Data Sources;Dementia;Development;Diagnosis;disability;Disabled Persons;Disparity;Down's Syndrome;Early identification;effective intervention;Enrollment;Epidemiologic Factors;Epidemiology;Etiology;experience;Genetic;Goals;Health;health equity;health knowledge;Hispanic;Hispanic Populations;Impairment;improved;Incidence;indexing;Individual;innovation;Inpatients;insight;Insurance Carriers;Intellectual functioning disability;interest;Intervention;Investigation;large datasets;Lead;Life Expectancy;life span;Linear Models;Link;Long-Term Care;Longitudinal cohort;Low income;Low Income Population;Machine Learning;Medicaid;Medical;Medicare;Methods;Modeling;Morbidity - disease rate;mortality;National Institute on Aging;Neurofibrillary Tangles;novel;Obstructive Sleep Apnea;older adult;Outcome;Outpatients;Pain;Participant;Pattern;people of color;Persons;Policies;Population;population based;Population Heterogeneity;Population Research;Practice Guidelines;Premature Mortality;Prevalence;prevent;Procedures;Production;programs;Proxy;Public Health;public health insurance;Quality of life;Race;racism;random forest;regression trees;Research;Research Personnel;resilience;Retrospective cohort;Risk;Risk Assessment;Sampling;Senile Plaques;Services;sex;Sleep;social determinants;social health determinants;Specificity;Statistical Methods;success;System;treatment guidelines;trend;Trisomy;United States Centers for Medicare and Medicaid Services;United States National Institutes of Health;ventilation;Wisconsin;Work

PROJECT_TITLE: Down Syndrome: Toward Optimal Trajectories and Health Equity using Medicaid Analytic eXtract (DS -TO-THE-MAX)

STUDY_SECTION: NAME

STUDY_SECTION_NAME: Neurological, Aging and Musculoskeletal Epidemiology Study Section[NAME]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Down Syndrome;Genetics;Intellectual and Developmental Disabilities (IDD);Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: PISCATAWAY

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: RUTGERS, THE STATE UNIV OF N.J.

ORG_STATE: NJ

PHR: Project Narrative: Down syndrome (DS), caused by triplication of human chromosome 21, is the single most common risk factor for Alzheimer’s disease (AD) and people with DS typically develop early-onset AD and dementia by their 60s. Here, we propose to employ a novel human microglial chimeric mouse brain model that is created by transplantation of human DS induced pluripotent stem cell-derived microglia to study the role of human microglia in AD/DS in vivo. Results from this study will help us better understand the mechanisms underlying the AD in DS and may steer AD therapeutic interventions into a new direction of aiming at preventing microglial senescence or rejuvenating microglia.

PI_NAMEs: JIANG, PENG  (contact)

PROGRAM_OFFICER_NAME: OPANASHUK, LISA A

PROJECT_TERMS: abeta accumulation;Acceleration;Adult;Age;Aging;aging brain;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease risk;Alzheimer's disease therapeutic;Animals;Behavior;Behavioral;beta amyloid pathology;Brain;Brain region;brain tissue;Candidate Disease Gene;Cell Senescence Induction;Chimera organism;Chromosome 21;comparison control;CRISPR/Cas technology;cytokine;Data;Dementia;Development;Disease;Disease Progression;dosage;Down's Syndrome;Early Onset Alzheimer Disease;Electrophysiology (science);Engraftment;Excision;Exhibits;Exposure to;Foundations;Four-dimensional;Functional disorder;Gene Expression Profile;General Population;Genes;Genetic;genome editing;genome wide association study;glial activation;Goals;Hippocampal Formation;Human;Human Chromosomes;human induced pluripotent stem cells;human tissue;hyperphosphorylated tau;IFNAR1 gene;Imaging technology;Impaired cognition;Impairment;in vivo;Incentives;induced pluripotent stem cell;Injections;insight;Interferons;invention;Knock-out;Learning;Life;Link;Macrophage;Mediating;Memory;Memory impairment;Microglia;microscopic imaging;Modeling;Molecular;mouse model;Mus;Nerve Degeneration;nerve stem cell;Neurodegenerative Disorders;Neurons;neurotrophic factor;new therapeutic target;novel;novel therapeutic intervention;novel therapeutics;Organoids;Pathogenicity;Pathologic;Pathology;Patients;Performance;Persons;Phenotype;Population;prevent;Rejuvenation;Reporting;Research;response;Risk Reduction;risk variant;robotic microscopy;Robotics;Role;senescence;Senile Plaques;Signal Transduction;single-cell RNA sequencing;Slice;synaptic function;Synaptic plasticity;synaptic pruning;tau Proteins;tau-1;Technology;Testing;Therapeutic Intervention;tool;transcriptome;transcriptomics;Transgenic Mice;Transplantation

PROJECT_TITLE: A Human iPSC-Based Chimeric Mouse Model of Alzheimers Disease in Down Syndrome

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-W(55)]


ORG_CITY: CAGUAS

ORG_NAME: SAN JUAN BAUTISTA SCHOOL OF MEDICINE

ORG_STATE: PR

PI_NAMEs: ESTAPE, ESTELA S (contact)

PROGRAM_OFFICER_NAME: AGGARWAL, MONIKA

PROJECT_TERMS: Address;Area;Biomedical Research;Cardiovascular Diseases;Cell Culture Techniques;Child Health;Clinical Research;Collaborations;Communicable Diseases;Communities;Darkness;Data;Data Analyses;Development;Doctor of Philosophy;Equipment;Faculty;Grant;health disparity;health equity;Hispanic;Hispanic Populations;Hispanic-serving Institution;Inflammation;Infrastructure;Institution;Interdisciplinary Study;Island;Laboratories;Malignant Neoplasms;medical schools;minority health disparity;Modernization;Population;Preparation;programs;Puerto Rico;Research;research facility;Research Infrastructure;Research Personnel;Research Priority;Research Project Grants;Research Training;Resources;sample collection;Students;Training;Translational Research;Trauma;Violence;Women's study;Youth

PROJECT_TITLE: SJB Biomedical Research Center for Hispanic Health Disparities


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Neurosciences;Sleep Research

ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: PROJECT NARRATIVE Memories are highly dependent upon the context in which they are embedded, yet neurocognitive models of human sleep consolidation downplay the role of context and focus instead on the reactivation (or “replay”) of individual, isolated memory traces. This proposal will disentangle the roles of individual memories and generalized contexts in sleep-related reactivation using functional MRI, EEG and behavioral methods for sleep manipulation, thereby creating a unified framework linking the context-memory literature, the nonhuman replay literature, and the human reactivation literature. The possibility of reinstating context during sleep will be exploited to weaken memories reactivated in a suppression context, providing evidence for the translational nature of the developed framework and possibly paving the way toward non-invasive memory-altering interventions for healthy and clinical populations.

PI_NAMEs: SCHECHTMAN-DRAYMAN, EITAN  (contact)

PROGRAM_OFFICER_NAME: RANGEL GOMEZ, MAURICIO

PROJECT_TERMS: Animals;Applied Research;arm;Auditory;Award;Basic Science;Behavior;Behavior Control;Behavioral;Biological Sciences;Brain;California;career;Clinical;clinically relevant;Cognition;Complement;Comprehension;Computer Models;Computing Methodologies;Cues;Data;Data Analyses;Decision Making;Dependence;design;Development;Dimensions;Electroencephalography;Electrophysiology (science);Event;experience;experimental study;Frequencies;Functional Magnetic Resonance Imaging;functional magnetic resonance imaging/electroencephalography;Future;Goals;Hippocampus;Human;human model;improved;Individual;Infrastructure;Intervention;Learning;Life;Link;Literature;machine learning algorithm;Memory;memory consolidation;memory process;Mental disorders;Mental Health;Mentors;Methods;Modeling;Molds;Monitor;Multivariate Analysis;Nature;Network-based;neural;neural patterning;Neurobiology;Neurocognitive;Neurons;novel;Odors;outreach;Participant;Pattern;Personal Satisfaction;Phase;Play;Population;Post-Traumatic Stress Disorders;Process;Prognosis;Research;Retrieval;Role;Schools;Semantics;skills;Sleep;sound;spatiotemporal;Stimulus;Symptoms;Techniques;Testing;Training;Training Support;Trauma;Universities;Vacuum;Work

PROJECT_TITLE: The role of context in sleep-related memory reactivation in humans

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: AT

ED_INST_TYPE: SCH OF HOME ECON/HUMAN ECOLOGY

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Depression;Diabetes;Mental Health;Mental Illness;Nutrition;Obesity;Pediatric;Prevention

ORG_CITY: FORT COLLINS

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: COLORADO STATE UNIVERSITY

ORG_STATE: CO

PHR: Project Narrative The proposed research is highly relevant to public health because the identification of feasible, brief, and cost- effective interventions to decrease depression symptoms in adolescents with overweight/obesity offers the prospect of decreasing insulin resistance, and consequently, mitigating the risk of developing type 2 diabetes (T2D). Adolescents from historically disadvantaged racial/ethnic and socioeconomic backgrounds disproportionately face major stressful life events and psychosocial adversity, develop depression, and experience a high prevalence of obesity and earlier-life onset of T2D. By systematically studying the usefulness of a mindfulness-based intervention to decrease depression, and ultimately, to decrease insulin resistance in adolescents at-risk for T2D, the proposed research is highly consistent with NCCIH's mission to apply rigorous scientific methods to the identification of complementary and integrative health interventions and their roles in improving health and healthcare.

PI_NAMEs: SHOMAKER, LAUREN BERGER (contact)

PROGRAM_OFFICER_NAME: JEAN-FRANCOIS, BEDA

PROJECT_TERMS: acceptability and feasibility;Accounting;active method;Adherence;Adolescent;Adult;Affect;Aftercare;American;Area;Behavior;Behavioral;behavioral health;Body Weight decreased;care costs;Cause of Death;child depression;Chronic Disease;Cognitive Therapy;comorbidity;Competence;Complementary Health;Control Groups;cost;cost effective intervention;Data;depression model;depressive symptoms;Diabetes prevention;diabetes risk;Disadvantaged;Disease;Eating;Educational Intervention;Effectiveness;efficacy trial;Ethnic Origin;experience;Face;Feasibility Studies;Female Adolescents;Focus Groups;follow-up;Future;Geography;Health;Health education;Health Expenditures;Healthcare;Healthy Eating;hedonic;High Prevalence;high risk;Hydrocortisone;improved;innovation;Insulin Resistance;Integrative Medicine;Intervention;intervention program;Learning;Life;Life Expectancy;lifestyle intervention;Longterm Follow-up;Male Adolescents;meetings;Mental Depression;Methods;mindfulness intervention;Mission;Modality;Modeling;modifiable risk;National Center for Complementary and Integrative Health;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;Overweight;Pattern;Persons;physical inactivity;Physiological;Physiology;Pilot Projects;Preparation;prevent;Procedures;programs;prospective;Protocols documentation;psychosocial;Public Health;Race;Randomized;Randomized, Controlled Trials;recruit;Research;Risk;Risk Factors;risk mitigation;Role;Sampling;Site;socioeconomics;standard of care;Stress;stress reactivity;Stressful Event;Target Populations;Testing;theories;Time;Training;Work

PROJECT_TITLE: Mindfulness-Based Intervention for Depression and Insulin Resistance in Adolescents


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Duchenne/ Becker Muscular Dystrophy;Genetics;Muscular Dystrophy;Pediatric;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: PHILADELPHIA

ORG_DEPT: ORTHOPEDICS

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative In Duchenne Muscular Dystrophy (DMD) the repeated cycles of muscle damage and repair lead to stem cell dysfunction but current therapies do not target muscle stem cells. The studies proposed here will assess the importance of telomere biology in the progression of muscular dystrophy, using new genetic mouse models that target the stem cell compartment. Our research is aiming to investigate the molecular mechanism of telomere dysfunction in skeletal muscle dystrophy.

PI_NAMEs: MOURKIOTI, FOTEINI  (contact)

PROGRAM_OFFICER_NAME: CARIFI, EMILY FORAN

PROJECT_TERMS: Ablation;Adrenal Cortex Hormones;Age;Apoptosis;Binding;Biology;Breeding;Bypass;Cell Compartmentation;Cell Count;cellular imaging;Childhood;Creatine Kinase;Cytokinesis;Data;Defect;Disease Progression;DNA Binding;DNA Damage;DNA-Binding Proteins;Duchenne muscular dystrophy;Environment;Etiology;Event;exhaustion;Functional disorder;Genes;Genetic;Genetic Transcription;Histology;Human;Imaging Techniques;in vivo;injured;innovation;Knock-out;Knockout Mice;Lead;Length;Link;Methods;Molecular;Monitor;mouse model;Mus;Muscle;muscle degeneration;muscle hypertrophy;muscle progenitor cell;muscle regeneration;Muscle satellite cell;Muscular Dystrophies;Mutation;Myopathy;Natural regeneration;Necrosis;novel;Outcome;Patients;prevent;Proteins;Regulation;repaired;Reporter;Research;response to injury;Role;Scheme;senescence;Serum;Signal Pathway;Signal Transduction;Skeletal Muscle;stem cell proliferation;stem cells;telomere;Telomere Shortening;Testing;Time;Tissues;two photon microscopy;XRCC5 gene

PROJECT_TITLE: Molecular mechanisms of telomere function in muscle stem cells

STUDY_SECTION: SMEP

STUDY_SECTION_NAME: Skeletal Muscle and Exercise Physiology Study Section[SMEP]


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Clinical Research;Hematology;Lung;Pain Research;Rare Diseases;Sickle Cell Disease

ORG_CITY: MILWAUKEE

ORG_NAME: VERSITI WISCONSIN, INC.

ORG_STATE: WI

PHR: Project Narrative Sickle Cell Disease (SCD) is a genetically inherited disease that affects 100,000 Americans and millions world- wide. Acute chest syndrome (ACS) is a type of lung injury and one of the leading causes of hospitalization among SCD patients; however, there is no available treatment to prevent ACS. We propose to identify new molecular targets that can be blocked therapeutically to prevent ACS in SCD patients.

PI_NAMEs: SUNDD, PRITHU  (contact)

PROGRAM_OFFICER_NAME: AGRAWAL, NITIN

PROJECT_TERMS: Acute;acute chest syndrome;Acute Lung Injury;Address;Affect;American;arteriole;Biochemical;Blood;Blood capillaries;Blood Cells;Blood flow;Blood Platelets;Caspase;Cell Nucleus;Clinical Trials;Development;Dyes;Embolism;Epidemiology;Etiology;Event;Experimental Hematology;extracellular;Generations;Hemin;Hemoglobin;Hemorrhage;Hereditary Disease;Hospitalization;Human;Image;In Vitro;in vivo;in vivo imaging;Inflammation;Inflammatory;Injury;insight;Intravenous;Liver;Liver Circulation;Lung;lung imaging;lung injury;Mediating;Microfluidics;Modeling;Molecular;Molecular Target;mortality;mouse model;multiphoton microscopy;Mus;neutrophil;Neutrophil Activation;novel;novel therapeutics;P-Selectin;Pain;Pathologic;Patients;Pattern;Platelet aggregation;prevent;Publishing;Reactive Oxygen Species;Reporting;Secondary to;Sickle Cell Anemia;Signal Transduction;Sterility;targeted treatment;Testing;Therapeutic;Time;Travel;VDAC1 gene

PROJECT_TITLE: Pulmonary arteriole occlusion by platelet-neutrophil micro-emboli in Acute Chest Syndrome

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


ED_INST_TYPE: SCHOOLS OF OSTEOPATHIC MEDICINE

ORG_CITY: ATHENS

ORG_NAME: OHIO UNIVERSITY ATHENS

ORG_STATE: OH

PI_NAMEs: BERRYMAN, DARLENE E (contact)

PROJECT_TERMS: aged;Aging;aging in place;Animal Disease Models;animal facility;Animal Housing;Animals;Biomedical Research;biosecurity;Center for Translational Science Activities;Clinical;Collaborations;Communities;Diabetes Mellitus;Education;Environment;Equipment;Faculty;Floor;Fostering;Funding;Future;graduate student;improved;Infrastructure;Institution;Investments;medical schools;Medical Students;member;Mission;Modernization;multidisciplinary;Mus;Musculoskeletal;Names;Neurologic;novel;Obesity;Ohio;Osteopathic Medicine;Pain;Patient Care;population health;Research;research facility;Research Infrastructure;Research Institute;Research Personnel;Rodent;Science;Scientist;Secure;success;Tissues;Training;Translational Research;undergraduate student;United States National Institutes of Health;Universities

PROJECT_TITLE: New Vivarium to Expand Biomedical Research Capacity at Ohio University


ORG_CITY: SANTA MONICA

ORG_NAME: RAND CORPORATION

PHR: Project Narrative: Reducing variance in psychiatric diagnostic practice is one step toward diagnostic accuracy, because without consistency (i.e. precision in statistical terms), accuracy cannot be achieved. We propose to reduce diagnostic variance for mental health and thereby improve patient safety at two health system partners and in a national sample of physicians. We will reduce diagnostic variance by measuring between-provider differences in diagnostic practice with a mixed-method research design, quantifying between-provider agreement and agreement of providers with published diagnostic systems, and providing direct feedback to partners about their own levels of diagnostic agreement and variance.

PI_NAMEs: MATTHEWS, LUKE  (contact)

PROGRAM_OFFICER_NAME: HAUGSTETTER, MONIKA

PROJECT_TITLE: Reducing Variance in Diagnosis of Mental Disorders to Improve Patient Safety


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Cancer;Genetics;Immunotherapy;Neurofibromatosis;Neurosciences;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

PHR: Public Health Relevance Neurofibromatosis type 1 (NF1) is a genetic disorder that predisposes affected individuals to tumors of the nervous system, and other disease manifestations. To identify how tumors form we are using mouse models and modern methodologies to study tumour-immune interactions. These state-of-the art interdisciplinary approaches allow us to study the role of NF1, early stages of tumorigenesis and to identify points for tumour prevention and therapeutic intervention.

PI_NAMEs: RATNER, NANCY  (contact)

PROGRAM_OFFICER_NAME: LEE, CRYSTAL ANNE

PROJECT_TERMS: Adoptive Transfer;Affect;Alleles;Animal Model;Animals;Antibodies;Antigen Presentation;Antigen-Presenting Cells;B-Lymphocytes;Back;Benign;CD8-Positive T-Lymphocytes;cell dedifferentiation;Cell Line;Cell model;cell type;Cells;Characteristics;chemokine;CXCL10 gene;CXCL9 gene;CXCR3 gene;cytokine;Data;Dendritic Cells;Development;disabled;Disease;Fibroblasts;G Protein-Coupled Receptor Signaling;Gene Expression;Genetic Diseases;Hereditary Disease;Immune;In Vitro;Individual;interdisciplinary approach;Interferon Type I;Interferon Type II;Interferons;knockout gene;Link;Macrophage;Maintenance;Methodology;Modernization;mouse model;Mus;neoplastic cell;Nervous System Neoplasms;neurofibroma;Neurofibromatoses;Neurofibromatosis 1;NF1 gene;NF1 mutation;Pathway interactions;Patients;Peripheral Nervous System;Peripheral Nervous System Neoplasms;precursor cell;preventive intervention;Production;public health relevance;Rag1 Mouse;receptor;Recording of previous events;recruit;response;RNA;Role;Schwann Cells;self-renewal;Signal Transduction;single-cell RNA sequencing;Spleen;STAT3 gene;System;T-Cell Proliferation;T-Cell Receptor;T-Lymphocyte;Testing;Therapeutic Intervention;therapeutic target;transcriptome;transcriptomics;tumor;Tumor Antigens;tumor initiation;tumor specificity;tumorigenesis

PROJECT_TITLE: Mitogenic Activities in Neurofibromatosis

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


ED_INST_TYPE: SCHOOLS OF PHARMACY

ORG_CITY: TALLAHASSEE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: FLORIDA AGRICULTURAL AND MECHANICAL UNIV

PI_NAMEs: DARLING-REED, SELINA FAITH (contact)

PROGRAM_OFFICER_NAME: SPECTOR, JEFFREY O

PROJECT_TERMS: African American;African American population;Architecture;Behavioral;Behavioral Research;Biomedical Research;California;Classification;Collaborations;college;Communities;community center;community engagement;Community Outreach;Core Facility;Cost Analysis;County;design;Floor;Florida;Fostering;Funding;Funding Agency;Future;Geography;Goals;Health Disparities Research;health equity;Historically Black Colleges and Universities;Infrastructure;innovation;Institution;Instruction;Leadership;Life Cycle Stages;minority health;minority health disparity;minority student;Minority-Serving Institution;Mission;multidisciplinary;National Cancer Institute;outreach;Pharmacologic Substance;Pharmacy facility;Phase;Public Health;Reduce health disparities;Research;Research Activity;Research Personnel;Science;Services;sound;square foot;stem;Technology;United States National Institutes of Health;Universities

PROJECT_TITLE: Expanding Infrastructure for Translational and Health Disparities Research at Florida A&M University


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cocaine;Drug Abuse (NIDA only);Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: SPRINGFIELD

ORG_NAME: SOUTHERN ILLINOIS UNIVERSITY SCH OF MED

ORG_STATE: IL

PHR: Project Narrative There are currently no effective treatment options for cocaine addiction. While some of the risk factors and neural substrates involved have been elucidated, our limited understanding has impeded the development of effective treatments for this brain disorder. In this proposal, we examine cellular substrates associate with cocaine aversion, whose elucidation may help develop more effective therapies against this devastating condition.

PI_NAMEs: CARRERO, JEFFREY PARRILLA (contact)

PROGRAM_OFFICER_NAME: BERTON, OLIVIER

PROJECT_TERMS: addiction;Address;Affect;Automobile Driving;avoidance behavior;Behavior;Behavioral;Brain;Brain Diseases;Calcium;cell type;Cells;Chronic;Cocaine;Cocaine Dependence;cocaine seeking;Data;Development;Dopamine D2 Receptor;drug of abuse;drug relapse;Drug usage;effective therapy;Exhibits;Exposure to;Fiber;Future;Gene Expression;Genes;genetic manipulation;Glutamates;Goals;Impairment;in vivo;Individual;Individual Differences;individual variation;innovation;Knowledge;Link;Long-Term Depression;Measures;Mentors;Messenger RNA;Methods;Molecular;mRNA Expression;neural;neuroadaptation;neuronal excitability;Neuronal Plasticity;Neurons;Neurosciences;Nicotine;novel;Nucleus Accumbens;optogenetics;Pattern;Persons;Pharmaceutical Preparations;Phase;Phenotype;Predisposing Factor;prevent;programs;Property;Rattus;Research;response;Rewards;Risk Factors;Role;selective expression;sensor;Signal Transduction;skills;Smoking;Substance Use Disorder;Synapses;Testing;Therapeutic;Training;Translations;transmission process

PROJECT_TITLE: Cell-Types Specific Neuroadaptations in the Nucleus Accumbens Shell Associated with Individual Differences in Cocaine-Seeking

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Emerging Infectious Diseases;Infectious Diseases;Lung;Rare Diseases;Tuberculosis

ORG_CITY: SAN ANTONIO

ORG_NAME: TEXAS BIOMEDICAL RESEARCH INSTITUTE

PHR: Research Narrative Tuberculosis (TB) remains a major health problem in the world. While TB is primarily a disease of the lungs, extrapulmonary TB is common in children and immunocompromised individuals. We propose combining mathe- matical modeling and experiments to gain insights into mechanisms of Mtb dissemination using a novel system of infection of mice with an ultra low dose (1-3) of bacteria.

PI_NAMEs: GANUSOV, VITALY V. (contact)

PROGRAM_OFFICER_NAME: LACOURCIERE, KAREN A

PROJECT_TERMS: Adult;Advocate;Animal Model;Bacteria;Bar Codes;Blood specimen;CD4 Positive T Lymphocytes;Cells;Cessation of life;Child;Clinical;Colony-forming units;Communicable Diseases;Computational Biology;conventional dosing;Data;Data Analyses;Deposition;design;Diagnosis;dimension reduction;Disease;Disease Progression;Dose;Experimental Models;experimental study;Focal Infection;Gene Expression Profile;Genetic Markers;genetic signature;Goals;Granuloma;graph theory;Health;Hematogenous;Hematogenous Spread;HIV;Human;human disease;Immune;Immunity;Immunocompromised Host;improved;in vivo;Individual;Infection;innovation;insight;Kinetics;Licensing;Lung;Lung Diseases;Lung infections;lung lobe;lung upper lobe;lymph nodes;Macrophage;mathematical model;Mediating;Messenger RNA;Methods;Micro Array Data;Modeling;Monkeys;mortality;Mus;Mycobacterium tuberculosis;Mycobacterium tuberculosis H37Rv;neutrophil;novel;novel marker;pathogen;Pathogenesis;Pathology;Pathway interactions;Patients;Plasmids;Population;predictive signature;Probability;Process;progression risk;Protocols documentation;Pulmonary alveolar structure;Repression;Research;Risk;Scientist;Site;Spleen;Supporting Cell;System;T cell response;Techniques;Testing;Time;Tissues;Tuberculosis;Tuberculosis Vaccines;vaccine development;Vaccines;Whole Blood

PROJECT_TITLE: Mathematical modeling of Mycobacterium tuberculosis dissemination

STUDY_SECTION: MABS

STUDY_SECTION_NAME: Modeling and Analysis of Biological Systems Study Section[MABS]


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety

ORG_CITY: Nashville

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: PROJECT NARRATIVE Artificial intelligence-driven robot-assisted surgery raises new ethical concerns relating to changes to surgeons’ professional autonomy, informed consent, confidentiality/privacy, and the surgeon-patient relationship. This study aims to examine ethical issues of informed consent and assess patient decision making for autonomous robot-assisted surgery. The impact of the proposed study will be to facilitate the adoption of innovative surgical techniques by better understanding ethical issues regarding autonomous robot-assisted surgery and guiding surgeon-patient communication so that the surgeon-patient relationship remains human-centered.

PI_NAMEs: GORDON, ELISA J;WU, JIE YING  (contact)

PROJECT_TERMS: Acceleration;Address;Adoption;Adult;Affect;American;Artificial Intelligence;artificial intelligence algorithm;Automobile Driving;Caring;clinical practice;cognitive interview;Collaborations;Communication;Computational algorithm;Conventional Surgery;Data;Decision Making;Devices;Disclosure;Educational Materials;Endowment;Ensure;Ethical Issues;Ethics;foot;General Population;Geography;Guidelines;Hemorrhage;Human;human centered design;improved;Informed Consent;innovation;instrument;Insurance;Interview;Mediation;Motor;Nurses;Operating Rooms;Operative Surgical Procedures;Outcome;Pamphlets;Patient Care;Patient Preferences;Patients;Perception;Postoperative Period;preference;Privacy;privacy protection;Procedures;Process;Professional Autonomy;Provider;provider communication;Race;Recovery;Research;Risk;Robot;robot assistance;robotic system;Robotics;Role;satisfaction;sensor;Shapes;sound;Stream;Surgeon;Surveys;Techniques;Technology;tool;Trust

PROJECT_TITLE: Ethical Approaches to Informed Consent for Autonomous Robotic Assisted Surgery


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: MOSCOW

ORG_NAME: UNIVERSITY OF IDAHO

ORG_STATE: ID

PHR: Project Narrative This INBRE administrative supplement pairs an INBRE and COBRE project leader for collaborative research to enhance their productivity and improve the environment for PUI undergraduate student research experiences. The project is relevant to the NIH and public health because it develops a novel insect model to study microbial pathogenesis that mimics the microbial content and physiological conditions of the human vaginal tract. It will lay the foundations for developing future therapies for vaginal infections by understanding the interactions that occur between pathogens and the microbiome.

PI_NAMEs: BOHACH, CAROLYN HOVDE (contact)

PROGRAM_OFFICER_NAME: FAUPEL-BADGER, JESSICA

PROJECT_TERMS: Administrative Supplement;Adopted;Affect;Animal Model;anti-fungal agents;antimicrobial;Applications Grants;Authorship;Azoles;Biological Models;Candida;Characteristics;Collaborations;collaborative approach;cost effective;Development;Disadvantaged;Disease;Disease Outcome;effective therapy;Ensure;Environment;environmental enrichment for laboratory animals;experience;Fostering;Foundations;Future;Goals;gut microbiome;high standard;Hindgut;Human;human pathogen;Idaho;improved;Individual;Infection;innate immune mechanisms;innovation;Insecta;insight;Invaded;Investigation;Laboratories;Lactobacillus;Larva;Link;Manuscripts;Mentorship;microbial;microbiome;microbiome composition;Midgut;model organism;Modeling;Molecular;Moths;mouse model;Nature;novel;novel therapeutic intervention;novel therapeutics;Oral Administration;Outcome;overexpression;pathogen;Pathogenesis;pathogenic bacteria;pathogenic fungus;Pathogenicity;Physiological;Predisposition;Productivity;programs;Proteins;Public Health;Publications;Recurrence;Reproducibility;Research;Research Personnel;Resistant candida;Role;Safety;skills;Students;Supervision;Testing;Therapeutic;Training;undergraduate research;undergraduate student;United States National Institutes of Health;Vagina;vaginal infection;vaginal mucosa;Vertebrates;Vulvovaginal Candidiasis;Waxes;Woman;yeast infection;Yeasts

PROJECT_TITLE: Idaho INBRE Program


ORG_CITY: LEXINGTON

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PI_NAMEs: KERN, PHILIP A (contact)

PROGRAM_OFFICER_NAME: CHEN, YONG

PROJECT_TERMS: Address;Aging;alcohol research;Alzheimer's Disease;Artificial Intelligence;Biomedical Research;Cancer Center;Certification;Clinical;clinical center;Clinical Sciences;Communication;Data;Data Analytics;data centers;data infrastructure;data management;data mining;data sharing;Data Storage and Retrieval;density;Direct Costs;Equipment;facility renovation;Funding;Goals;Grant;Health Insurance Portability and Accountability Act;High Performance Computing;Individual;Infrastructure;Kentucky;Machine Learning;meetings;models and simulation;Pharmaceutical Preparations;population health;Research;Research Personnel;Secure;Speed;square foot;Translational Research;Translations;United States National Institutes of Health;Universities;University resources

PROJECT_TITLE: University of Kentucky Center for Clinical and Translational Science Enterprise Data Center Expansion


ED_INST_TYPE: UNIVERSITY-WIDE

ORG_CITY: TOUGALOO

ORG_NAME: TOUGALOO COLLEGE

ORG_STATE: MS

PI_NAMEs: SAMPSON, III, JOSIAH J. (contact)

PROJECT_TERMS: academic program;Accreditation;African American;African American population;Award;Bachelor's Degree;Behavioral Sciences;Biomedical Research;Cardiovascular Diseases;Cardiovascular system;Chronic Disease;Collaborations;college;Communities;County;Dedications;Discipline;Doctor of Philosophy;Engineering;Faculty;falls;Federally Qualified Health Center;Female;Fostering;Grant;health disparity;Heart Diseases;Historically Black Colleges and Universities;Institution;interest;Jackson Heart Study;male;member;men;Mississippi;mortality;physical science;Privatization;programs;Qualifying;Research;Resources;Schools;Science;STEM career;Students;Training;undergraduate student;Woman

PROJECT_TITLE: Tougaloo College Biomedical Research & Training Center


ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PI_NAMEs: LYNCH, SUSAN VERONICA (contact)

PROJECT_TERMS: Acceleration;analytical tool;Attention;biological systems;California;Chemistry;Communities;cost;Data;Decentralization;design;Development;Education;energy efficiency;Extramural Activities;Fund Raising;Generations;Human Resources;Infrastructure;innovation;insight;Institution;instrument;Investments;Laboratories;Location;mass spectrometer;Mass Spectrum Analysis;metabolomics;Methodology;Modernization;next generation;Outsourcing;Research;Research Design;research facility;Research Personnel;Research Priority;research study;Resources;Sampling;San Francisco;small molecule;square foot;Standardization;Technology;Time;tool development;Training;Training and Education;training opportunity;Universities;Workforce Development

PROJECT_TITLE: Centralization and Modernization of a Quantitative Metabolomics Center


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

ORG_CITY: FAIRBANKS

ORG_NAME: UNIVERSITY OF ALASKA FAIRBANKS

ORG_STATE: AK

PHR: OVERALL NARRATIVE The Alaska Institutional Development Award (IDeA) IDeA Networks of Biomedical Research Excellence (INBRE) program invests in growing and enhancing the capacity of biomedical and behavioral health researchers to improve the health and well-being of Alaska and the nation. It also supports increasing and diversifying the pipeline of students seeking careers in biomedical research in Alaska. Through its One Health research theme and focus on health disparities in Alaska Native people, it emphasizes the importance of recognizing interconnections among the health of people, animals, and the environment to sustain healthy communities during a time of rapid change in the northern-most state.

PI_NAMEs: BARNES, BRIAN M (contact)

PROGRAM_OFFICER_NAME: ZHOU, YANG

PROJECT_TERMS: Address;Advisory Committees;Alaska;Alaska Native;Alaska Native population;Analytical Chemistry;Animals;Award;behavioral health;Behavioral Research;Biochemistry;Bioinformatics;biomarker development;Biomedical Research;Budgets;career;career development;Chemicals;Chemistry;Clinical Research;Collaborations;college;Communities;community based participatory research;community engaged research;community engagement;Counseling;Data Science;Development;Disparity;Ecosystem;Education;Educational workshop;Effectiveness;Environment;Environmental Health;Environmental Science;Evaluation;experience;Faculty;Family;Foundations;Funding;Future;Genomics;Goals;graduate student;Grant;Health;health disparity;health organization;health training;Home;Human;improved;Incentives;Individual;Information Dissemination;Infrastructure;Institution;Interdisciplinary Study;Internships;investigator training;Investments;Leadership;Mentors;Modernization;outreach;Participant;Peer Review;Personal Satisfaction;Persons;Pilot Projects;Preparation;Program Research Project Grants;programs;Recommendation;Reporting;Research;Research Personnel;Research Project Grants;Research Support;Research Training;Resource Sharing;Resources;response;Services;stable isotope;Structure;student participation;Students;success;symposium;System;Time;Training;training opportunity;Translational Research;tribal college;tribal health;Tribes;undergraduate student;Underrepresented Populations;Underserved Population;United States National Institutes of Health;Universities

PROJECT_TITLE: Alaska INBRE 4 One Health


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Genetics;Human Genome;Nutrition;Precision Medicine

ORG_CITY: FAYETTEVILLE

ORG_NAME: UNIVERSITY OF ARKANSAS AT FAYETTEVILLE

ORG_STATE: AR

PI_NAMEs: ZHUANG, XUAN  (contact)

PROGRAM_OFFICER_NAME: CUPIT, PAULINE

PROJECT_TERMS: Address;Arkansas;Complex;Comprehension;Data;Development;Diabetes Mellitus;Diet;Dietary Sugars;Disease;disease phenotype;Drosophila genus;Environment;Equilibrium;gene environment interaction;Gene Expression;Genes;Genetic;Genetic Variation;Genome;Heritability;human disease;Inbreeding;Knowledge;Link;Maps;Metabolic;Metabolic Diseases;Metabolism;metabolome;metabolomics;Mitochondria;molecular phenotype;multiple omics;novel;Obesity;Pathway interactions;Personal Satisfaction;phenome;Phenotype;Population;precision medicine;Predisposition;Research;Shapes;Stress;sugar;Systems Biology;trait;Transcript;transcriptome;transcriptomics;Variant

PROJECT_TITLE: Unraveling Gene-Environment Interactions Shaping Metabolism: A Multi-Omics Analysis in Drosophila


ORG_CITY: SALT LAKE CITY

ORG_NAME: VA SALT LAKE CITY HEALTHCARE SYSTEM

PHR: Retinal ganglion cells (RGCs) are the only output neurons which relay visual signals from the eyes to the brain. RGC death is a crucial element in many retinal diseases leading to blindness in veterans, such as glaucoma and traumatic optic neuropathy (TON). Because loss of RGCs will result in irreversible loss of vision and no effective treatment is currently available, effectively minimizing or preventing RGCs death and preserving vision are significant challenges faced by the VA healthcare system. This study will conduct proof-of-principle studies to establish the role of MHCI-TCR as a critical mediator of RGC death in retinal diseases, validate the efficacy of MHCI-TCR inhibitors on RGC protection, and establish the optimal strategy for using pharmacological agents regulating multiple mechanisms involved in RGC death for neuroprotection. The results of this study could provide valuable insights into the protection of neurons in eye diseases. Therefore, the experiments proposed in this study will have important implications in developing treatment strategies for VA patients.

PI_NAMEs: TIAN, NING  (contact)

PROJECT_TERMS: Animal Model;antagonist;Behavioral;Blindness;Brain;Brain Injuries;Cause of Death;Cell Death;cell type;Central Nervous System Diseases;Cessation of life;Cytoprotection;Defect;design;Diabetic Retinopathy;Diagnosis;disability;Disease;disease model;effective therapy;efficacy validation;Electrophysiology (science);Elements;excitotoxicity;experimental study;Eye;Eye diseases;Eye Injuries;Family member;Functional disorder;Funding;gene therapy;Genetic;Glaucoma;Glutamate Receptor;Glutamates;Healthcare;Healthcare Systems;Image;Immune;Immune response;In Vitro;in vivo;inhibitor;Injections;Injury;innovation;insight;Mediating;Mediator;Molecular;Mutation;N-Methylaspartate;Nature;Nerve Crush;Neurodegenerative Disorders;neuron loss;Neuronal Injury;Neurons;neuroprotection;Neuroprotective Agents;Neurosciences;novel;novel therapeutic intervention;Optic Nerve;Optic Nerve Injuries;Output;Pathogenesis;Pathologic;Pathologic Processes;Patients;pharmacologic;Play;Predisposition;preservation;Prevalence;prevent;Probability;Process;Property;protective effect;protective efficacy;Proteins;repaired;Research;Retina;Retinal Diseases;retinal ganglion cell degeneration;Retinal Ganglion Cells;retinal ischemia;Role;Signal Pathway;Signal Transduction;Src family kinase inhibitor PP2;Stem cell transplant;success;T-Cell Receptor;Therapeutic;Traumatic Brain Injury;treatment strategy;Veterans;Vision;Visual;visual dysfunction;Visual impairment;ZAP-70 Gene

PROJECT_TITLE: Immune Responses in Neuronal Cell Death


ORG_CITY: Aurora

ORG_NAME: VA EASTERN COLORADO HEALTH CARE SYSTEM

PHR: Combat exposures such as inhaled sand and dust may lead to increased risk and severity of respiratory diseases including pulmonary fibrosis (PF) among Veterans. In addition, chronic psychological stress related to deployment is associated with chronic inflammation and may contribute to disease severity. Using a model of PF that mimics sand inhalation, combined with a model of chronic unpredictable stress (CUS), a novel circulating fibroblast precursor (CFP) cell was identified that is increased, activated, and promotes inflammation in PF. This study will determine how CUS exacerbates PF and identify CUS-driven mechanisms by which CFPs become activated to promote disease progression toward development of new therapies for PF. These studies are directly applicable to Veterans as they address the impact of chronic stress/mental health on a devastating disease disproportionately affecting our Nation’s Veterans.

PI_NAMEs: MCDONALD, LINDSAY THERESA (contact)

PROJECT_TERMS: Address;Adoptive Transfer;Affect;Age;animal imaging;Animals;antagonist;Area;Behavioral;career;Categories;Cells;Chronic;Chronic stress;clinically relevant;Collaborations;Collagen;Collagen Receptors;combat;Communities;comorbidity;Core Facility;Corticosterone;cost;Coughing;cytokine;Data;Development;discoidin domain receptor 2;Disease;Disease Progression;Disease Surveillance;Dust;Dyspnea;early onset;Effectiveness;Ensure;Exhibits;experience;Exposure to;Fatigue;Fibroblasts;Fibrosis;fibrotic lung;gain of function;Glucocorticoid Receptor;Glucocorticoids;Goals;Gulf War;Health;health care service utilization;Healthcare;Histologic;Hormones;Hydrocortisone;idiopathic pulmonary fibrosis;Immune;immune function;Immune response;Immunology;improved;In Vitro;in vitro Assay;in vivo;Incidence;Inflammation;Inflammatory;Inhalation;inhibitor;innovation;insight;Laboratories;loss of function;Lung;Lung Diseases;MEKs;Mental Health;Mental Health Associations;Mentors;Metyrapone;microCT;Mifepristone;military veteran;Mission;Modeling;Molecular;monocyte;multidisciplinary;Mus;Myelogenous;Myeloid Cells;Nature;new therapeutic target;novel;novel therapeutics;occupational hazard;Pathologic;Pathway interactions;Phenotype;Population;pre-clinical;precursor cell;Production;programs;Psychological Stress;Publications;Pulmonary Fibrosis;Pulmonary function tests;Reporting;Research;Research Personnel;Resistance;Respiratory Disease;response;Risk;Risk Factors;Role;Severities;Severity of illness;Signal Pathway;Signal Transduction;Silicon Dioxide;small hairpin RNA;statistics;Steroid Resistance;Steroids;Stress;success;T-Lymphocyte;targeted treatment;Technical Expertise;Testing;Therapeutic;therapeutic target;tool;Training;Transplantation;Veterans;Work

PROJECT_TITLE: Targeting the myeloid lineage to inhibit exacerbation of pulmonary fibrosis due to chronic stress


PHR: Cigarette smoking is a significant and modifiable risk factor for many diseases that afflict those in the VA health system. However, as part of the attempt to quit smoking many Veterans are turning to electronic nicotine delivery systems, ENDS, (or 'Vaping'), which delivers nicotine to the lung in unprecedented high amounts and purity (compared to cigarette smoke). We know little about the effects on the lung by ENDS:nicotine (or the chemicals in the carrier solutions) and even less about how they affect recovery of the already damaged lung by prior smoking. The aim of this proposal is to determine how ENDS:nicotine affects normal lung function and measure its influence on recovery from lung damage induced by previous cigarette smoke exposure.

PI_NAMEs: CARLSON, NOEL G. (contact);GAHRING, LORISE C

PROJECT_TERMS: Address;aerosolized;Affect;Alveolar;Alveolar Macrophages;Animal Experiments;base;Calcium;Cells;Chemicals;chemokine;cigarette smoke;cigarette smoking;Collagen;cytokine;Deposition;design;Disease;electronic liquid;Electronic Nicotine Delivery Systems;eosinophil;Eotaxin;experience;experimental study;Exposure to;exposure to cigarette smoke;Fibrosis;Gene Expression;Genetic Transcription;Glycerol;Health;Health system;Heating;House Dust Mite Allergens;Immune;immune function;Immune response;Immunology;immunoregulation;In Vitro;Inhalation;inhibitor;Interleukin-10;Interleukin-4;Investigation;Ion Channel;Kinetics;Liquid substance;Lung;lung injury;Macrophage Activation;Measurement;Measures;Methods;modifiable risk;Morphology;Mucins;Mus;Mutation;Nicotine;nicotine exposure;nicotine self-administration;nicotine use;Nicotinic Receptors;Pharmaceutical Preparations;Polyethylene Glycols;positive allosteric modulator;Process;Production;pulmonary function;Pyroglyphidae;rapid growth;receptor;Recovery;Recovery of Function;Reproducibility;response;Reverse Transcriptase Polymerase Chain Reaction;Risk;Risk Factors;RNA;Route;Salts;Sentinel;Signal Pathway;Signal Transduction;Smoking;smoking cessation;smoking exposure;Sodium Chloride;Specificity;System;Tissues;transcriptome sequencing;treatment response;uptake;vaping;vaporization;Vegetables;Veterans

PROJECT_TITLE: How nicotine delivered by Electronic Nicotine Delivery Systems (ENDS) affects the lung and its recovery from cigarette smoking