NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Cancer;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

PI_NAMEs: LEES, JACQUELINE A. (contact)

PROJECT_TERMS: 3-Dimensional;Acceleration;Anatomy;animal imaging;Animal Model;Animals;anti-cancer research;Autopsy;Biochemical;Biological Assay;Biological Models;Bioluminescence;biomaterial compatibility;Blood;Breeding;Budgets;Cancer Center Support Grant;cancer therapy;Cell Culture System;Cell model;Cells;Cellular biology;clinical implementation;Collection;Communities;Complex;Consultations;contrast enhanced;contrast imaging;CRISPR/Cas technology;data acquisition;Data Analyses;data resource;Decision Making;Detection;Development;Devices;Diagnosis;disease model;Dose;Drug Delivery Systems;Drug Kinetics;Educational workshop;Electron Microscopy;Embryo;embryonic stem cell;Emerging Technologies;Engineering;Evaluation;Feedback;Fees;Fluorescence;Fluorine;Funding;Generations;Genes;genome editing;Genotype;Goals;Health;Image;Image Analysis;Image Enhancement;image processing;imaging capabilities;Imaging technology;In Vitro;in vivo;Institution;instrumentation;Laboratories;light microscopy;Machine Learning;machine learning algorithm;Magnetic Resonance Imaging;Magnetic Resonance Spectroscopy;member;Methods;Microbubbles;microCT;Mission;Modeling;Monitor;monitoring device;mouse model;Mus;nanomaterials;Neoplasm Metastasis;novel strategies;novel therapeutic intervention;Oncogenes;Operative Surgical Procedures;Organoids;parallelization;PET/CT scan;Pharmaceutical Preparations;Pre-Clinical Model;Preclinical Testing;Production;programs;quantitative imaging;Recommendation;reconstruction;Regimen;repository;Research;Research Personnel;Research Support;Resistance;Resource Sharing;Resources;response;Role;Series;Services;Source;Specialist;Speed;stem;success;Tail;technology development;technology platform;Testing;testing services;Therapeutic;therapy resistant;tissue culture;tool;Toxicology;Training;Training Technics;Translations;treatment response;tumor;ultrasound;Update;Vaccines;Veins;Wages;whole animal imaging;Xenograft procedure

PROJECT_TITLE: Preclinical Modeling, Imaging & Testing


ADMINISTERING_IC: NS

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Aging;Biodefense and Related Countermeasures;Brain Disorders;Cerebrovascular;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Malaria;Neurodegenerative;Neurosciences;Pediatric;Pediatric - AIDS;Prevention;Rare Diseases;Vector-Borne Diseases

ORG_CITY: ROCHESTER

ORG_COUNTRY: UNITED STATES

ORG_DEPT: NEUROLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF ROCHESTER

ORG_STATE: NY

PHR: NARRATIVE This global neurology research program award (RPA) will leverage resources from ongoing collaborations to conduct clinical investigations of neuroinflammation in cerebral malaria and epidemiological studies of accelerated nervous system aging in the setting of chronic HIV infection. The effects of SARS-CoV-2 co- infection on the neuroinflammatory processes associated with cerebral malaria and nervous system aging in HIV will also be examined. Research infrastructure and personnel from this RPA will provide capacity building and educational opportunities for both US and African trainees.

PI_NAMEs: BIRBECK, GRETCHEN L. (contact)

PROGRAM_OFFICER_NAME: SRINIVASAN, SUDHA

PROJECT_TERMS: 2019-nCoV;Acceleration;Acute;Adult;Africa;African;age acceleration;Aging;antipyretic;antiretroviral therapy;Award;Caring;Cerebral Malaria;Cerebrovascular Disorders;Cessation of life;Child;Chronic;Clinic;clinical investigation;co-infection;Collaborations;Communities;Disease;Education;Environment;epidemiology study;Hemorrhage;HIV;HIV Infections;HIV therapy;imaging study;Impaired cognition;Infection;Inflammation;Inflammatory;Infrastructure;Injury;Investigation;Ischemia;Laboratories;Malaria;Malawi;Mentorship;Metabolic;Monitor;Morbidity - disease rate;Nervous System;Nervous System Disorder;neuroAIDS;neuroimaging;neuroinflammation;Neurologic;Neurological outcome;Neurology;Neuropathy;novel;Parasites;Population;premature;Prevention;Process;programs;Prospective, cohort study;psychiatric symptom;Randomized, Controlled Trials;Reporting;Research;Research Activity;Research Infrastructure;Research Personnel;Resources;Risk Factors;Role;Rural;SARS-CoV-2 infection;Scholarship;Scientist;Seizures;Stroke;study population;Thrombosis;Work;Zambia

PROJECT_TITLE: Global Research Endeavors to Advance Treatment of Neurological Disorders in Africa (GREAT Neurology)


ADMINISTERING_IC: CA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

ORG_CITY: CAMBRIDGE

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

ORG_STATE: MA

PI_NAMEs: KNOUSE, KRISTIN A (contact)

PROJECT_TERMS: anti-cancer research;Binding Sites;Bioinformatics;Biological Markers;Biometry;Cancer Center Support Grant;Cells;Chromosome abnormality;Client;Cloud Computing;cluster computing;Communities;complex data;computer infrastructure;Computer software;computing resources;Consultations;cost;Data;Data Analyses;Data Set;Data Storage and Retrieval;Databases;Development;DNA Sequence Determination;Education;Educational workshop;Epigenetic Process;epigenomics;Event;Experimental Designs;experimental study;functional genomics;Funding;Gene Expression;Gene Expression Profiling;Generations;Genes;Genome;genome-wide;genomic data;Genomics;High Performance Computing;Informatics;informatics training;Institution;instrument;Investigation;Libraries;member;Messenger RNA;Methodology;Methods;MicroRNAs;Mission;Modernization;Modification;Mutation;open source;Pathway interactions;Point Mutation;Preparation;programs;Protocols documentation;Publications;Quality Control;Research;Research Institute;Research Personnel;Resource Sharing;Resources;RNA Splicing;Sampling;Services;Side;single cell genomics;SNP genotyping;success;Technology;therapeutic target;Training;transcription factor;transcriptome sequencing;web interface

PROJECT_TITLE: Integrated Genomics and Bioinformatics

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics;Prevention

ORG_CITY: BERKELEY

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

ORG_STATE: CA

PHR: The study of budding yeast has provided fundamental insights into cell biological processes and made critical contributions to the understanding and treatment of human disorders like diabetes, congenital disabilities, and cancer. My laboratory uses budding yeast to address important questions in three areas of cell biology, the higher-order organization of chromosomes, the prevention of chromosome damage and rearrangements, and the mitigation of environmental stress. The proposed studies will elucidate fundamental molecular mechanisms in chromosome and stress biology that potentially can be leveraged for biomedical and agricultural applications.

PI_NAMEs: KOSHLAND, DOUGLAS E (contact)

PROGRAM_OFFICER_NAME: MACARTHUR, LINDA

PROJECT_TERMS: Address;Agriculture;Area;Biological Process;Biology;cancer cell;Cell Physiology;Cells;Cellular biology;Cellular Stress;Chromatin;Chromosome Segregation;Chromosome Structures;Chromosomes;cohesin;Complex;Desiccation;Diabetes Mellitus;disability;Disease;DNA;DNA Damage;DNA Repair;DNA Sequence;ds-DNA;environmental change;Eukaryota;experimental study;Gene Expression Regulation;Genetic Transcription;Genome;Genome Stability;Higher Order Chromatin Structure;Homeostasis;Human;Hybrids;In Vitro;insight;Laboratories;lens;Maintenance;Malignant Neoplasms;member;Membrane;Modeling;Molecular;novel;Organism;prevent;Prevention;protein complex;Protein Family;Proteins;Regulation;repaired;RNA;Saccharomycetales;Single-Stranded DNA;Stress;Structure;sugar;Transcript;Yeasts

PROJECT_TITLE: Elucidating  chromosome structure and function through the lens of SMC complexes and R-loops

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-K(55)R]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer

PI_NAMEs: WHITE, FOREST M (contact)

PROJECT_TERMS: anti-cancer research;Binding;Biocompatible Materials;Biopolymers;Budgets;Cancer Center;Cancer Center Support Grant;Cells;Collaborations;Complex;Consultations;Data Analyses;Detection;Development;Disease;Education;equipment acquisition;Experimental Designs;Fractionation;Funding;High Pressure Liquid Chromatography;Hybrids;improved;Individual;Informatics;Information Centers;Institution;instrument;instrumentation;interest;Mass Spectrum Analysis;member;Membrane;metabolomics;Methods;Mission;Modernization;Modification;Monitor;operation;Organism;Peptide Synthesis;Peptides;Pharmaceutical Preparations;Post-Translational Protein Processing;programs;Proteins;Proteomics;relative cost;Research;Research Personnel;Resource Sharing;Resources;response;Sampling;Services;small molecule;Source;Specificity;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;Speed;success;Technical Expertise;Techniques;Technology;Tissues;Training;training opportunity;Update;Vendor

PROJECT_TITLE: Biopolymers & Proteomics


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Brain Disorders;Eye Disease and Disorders of Vision;Intellectual and Developmental Disabilities (IDD);Neurosciences

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: PROJECT NARRATIVE With this research we will investigate the role of interhemispheric connectivity in visual cortical structure and cortical visual impairment (CVI) in CDKL5 Deficiency Disorder (CDD). Specifically, we will determine how altered callosal connectivity resulting from loss of Cdkl5 impacts visual function in a mouse model of CDD. This work will provide critical insight into the circuitry underlying CVI in neurological disorders and pave the way for the development of future therapeutics.

PI_NAMEs: KELLY, ELYZA  (contact)

PROGRAM_OFFICER_NAME: KIM, JENNY LILY

PROJECT_TERMS: Adult;Anatomy;Animal Behavior;area striata;Axon;Behavioral;Boston;CDKL5 disorder;cell type;cerebral visual impairment;Clinic;comorbidity;Core Facility;Corpus Callosum;Defect;Depth Perception;design;Developed Countries;Development;Developmental Delay Disorders;Disease;effective therapy;Electrophysiology (science);epileptic encephalopathies;Exhibits;experience;experimental study;Eye;Future;Head;hippocampal pyramidal neuron;Image;Impairment;improved;in vivo;Individual;inhibitory neuron;innovation;insight;Knock-out;Knockout Mice;Laboratories;Life;Measures;Mentorship;mouse model;Mus;Mutant Strains Mice;Nervous System Disorder;Nervous System Physiology;Neurodevelopmental Disorder;Neurologic;Neurons;novel therapeutics;optogenetics;Parvalbumins;Pediatric Hospitals;Perception;Photic Stimulation;Physiological;Physiology;Pyramidal Cells;Quality of life;Research;Resolution;Rest;Role;Seizures;Speech;Structure;Synapses;Techniques;Testing;Thalamic structure;Therapeutic;Training;Vision;Visual Acuity;Visual Cortex;visual dysfunction;Visual evoked cortical potential;Visual impairment;visual processing;Visuospatial;Walking;Work

PROJECT_TITLE: Determining the Impact of Callosal Connectivity on Visual Cortical Structure and Cortical Visual Impairment in Cdkl5 Deficiency Disorder

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-2 Study Section [NST-2]


PI_NAMEs: BIRNBAUM, MICHAEL  (contact)

PROJECT_TERMS: anti-cancer research;Antibodies;Apoptosis;Bioinformatics;Budgets;Cancer Center Support Grant;Cell Cycle Progression;Cell Separation;Cell surface;Cells;Collaborations;Consultations;copolymer;Cytometry;data acquisition;Data Analyses;Detection;Development;DNA Damage;Education;Educational workshop;Engineering;Evaluation;Experimental Designs;Flow Cytometry;Fluorescence-Activated Cell Sorting;fluorophore;Funding;Genomics;Imaging technology;Individual;Information Centers;instrument;instrumentation;interest;Label;Lasers;member;Methods;Mission;Multiplexed Ion Beam Imaging;operation;Phenotype;Population;programs;Proteins;Protocols documentation;Recovery;Reporter Genes;Research;Research Personnel;Research Support;Resource Sharing;Resources;response;Robotics;Sampling;Services;single cell analysis;single cell mRNA sequencing;single-cell RNA sequencing;Source;Specialist;Speed;success;System;Technical Expertise;Techniques;Technology;Therapeutic;Training;training opportunity

PROJECT_TITLE: Flow Cytometry


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Neurosciences;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: BALTIMORE

ORG_DEPT: NEUROSCIENCES

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Relevance Oligodendrocyte precursor cells (OPCs) comprise an abundant, widely distributed population of glial cells that play critical roles in learning-induced de novo generation of myelin and regeneration of oligodendrocytes to allow myelin repair in diseases such as multiple sclerosis. This proposal will leverage novel tools and state-of- the-art approaches to define how aging – both at the cellular and organ level – influences the molecular characteristics of OPCs, their activity and their ability to produce extracellular matrix to support brain homeostasis and plasticity.

PI_NAMEs: BERGLES, DWIGHT E (contact);GOFF, LOYAL ANDREW

PROGRAM_OFFICER_NAME: OPANASHUK, LISA A

PROJECT_TERMS: Ablation;Address;Age;age effect;age related changes;Aging;aging brain;Amyotrophic Lateral Sclerosis;Animals;Antigen Presentation Pathway;Antigens;Astrocytes;Autophagocytosis;Back;Behavior;Brain;Brain Diseases;Brain region;Calcium;Calcium Signaling;Cell Aging;cell behavior;Cell division;cell motility;Cell Physiology;cell type;Cells;Characteristics;Chondroitin Sulfate A;Cicatrix;Complex;Computational Biology;conditional knockout;CSPG4 gene;cytokine;Data Set;density;design;Development;Disease;DNA Repair;Environment;environmental change;Exhibits;experience;Exposure to;Expression Profiling;Extracellular Matrix;Filopodia;Generations;Genetic Transcription;gray matter;Growth Factor;Heterogeneity;Homeostasis;Image;imaging study;Immune;in vivo;in vivo imaging;Inflammation;Inflammatory;Injury;innovation;insight;Ions;Knockout Mice;Knowledge;Learning;Life;Metabolic;Methodology;MHC antigen;MHC Class I Genes;Microglia;migration;millisecond;Molecular;Molecular Biology;Monitor;Motility;motor learning;Multiple Sclerosis;Mus;Myelin;Myelin Sheath;myelination;Natural regeneration;Nervous System;neural circuit;Neuroglia;Neurons;neurotransmission;Neurotransmitters;Norepinephrine;novel;novel strategies;oligodendrocyte progenitor;Oligodendroglia;Organ;Pattern;Phenotype;Physiological;Physiology;Play;Population;Population Dynamics;Population Heterogeneity;precursor cell;preservation;pro-aging;Process;Production;progenitor;Proliferating;Property;Proteoglycan;Radial;regeneration potential;Rejuvenation;repaired;response;Role;self renewing cell;senescence;Signal Transduction;single-cell RNA sequencing;Site;stem;Synapses;Testing;Therapeutic;Time;Tissues;tool;Transgenic Mice;Traumatic Brain Injury;two-photon;white matter;young adult

PROJECT_TITLE: Aging dependent transformation of oligodendrocyte precursor cells


PI_NAMEs: KOEHLER, ANGELA NICOLE (contact)

PROJECT_TERMS: assay development;Biocompatible Materials;Bioinformatics;Biological;Biological Assay;Budgets;Cancer Center;Cancer Center Support Grant;Cell Line;Cells;ChIP-seq;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Collection;Consultations;Core Facility;Custom;Data;Data Analyses;Data Set;design;Development;Drug Delivery Systems;drug discovery;Education;Educational workshop;Enzyme-Linked Immunosorbent Assay;Equipment;Evaluation;exome;Funding;gene discovery;Genetic;Genomics;Image;Imaging technology;Information Centers;Institution;instrumentation;interest;Libraries;Library Materials;light scattering;Liquid substance;machine learning algorithm;member;Methods;Mission;Mus;Mycoplasma;Preparation;programs;Research;Research Personnel;Resource Sharing;Resources;response;Robotics;Role;Sampling;Science;screening;Series;Services;small molecule;small molecule libraries;Source;Stains;success;System;Systems Biology;Technology;technology platform;Testing;tissue processing;tool;Toxicology;Training;training opportunity;Validation;Zebrafish

PROJECT_TITLE: High Throughput Sciences


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

ORG_CITY: PITTSBURGH

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project Narrative Telomerase is a prime target for cancer therapeutics since it is expressed in over 85% of cancers and enables unlimited cell division, but is lacking in most non-cancerous cells. This fellowship will investigate how the chemotherapeutic thiopurine, 6-thio-dG, inhibits telomerase’s ability to restore telomeres, causing telomere shortening and cellular growth arrest, and whether inhibiting thiopurine sanitase can improve 6-thio-dG efficacy. This study will provide mechanistic insight on how 6-thio-dG inhibits telomerase and halts cancer cell proliferation, which can inform future basic and clinical research studies.

PI_NAMEs: SANFORD, SAMANTHA  (contact)

PROGRAM_OFFICER_NAME: ODEH, HANA M

PROJECT_TERMS: Adult;Animals;base;Basic Science;Binding;Biochemical;Biochemistry;Biological Assay;cancer cell;Cancer Cell Growth;Cancer cell line;cancer therapy;cancer type;career development;Catalysis;Cell division;cell growth;Cell Line;Cell Proliferation;Cells;Chromosomes;clinical efficacy;Clinical Research;Data;Data Analyses;Deoxyguanosine;deoxyguanosine triphosphate;Dependence;design;Dissociation;DNA;DNA biosynthesis;DNA Damage;DNA-Directed DNA Polymerase;Dot Immunoblotting;Educational workshop;Effectiveness;Elongation by Telomerase;Event;experimental study;Fellowship;Fluorescent in Situ Hybridization;Functional disorder;Future;Growth;Human;Impairment;improved;in vivo;inhibitor;insight;International;Kinetics;knock-down;Length;leukemia;LOX gene;Malignant Childhood Neoplasm;Malignant Neoplasms;Measures;Melanoma Cell;Mentors;Metaphase;molecular imaging;Monitor;Mus;Myeloproliferative disease;nucleoside analog;Nucleotides;Oligonucleotides;Outcome;p53-binding protein 1;Pharmaceutical Preparations;Pharmacotherapy;prevent;Prodrugs;Property;Proteins;Research Personnel;Research Project Grants;research study;response;Reverse Transcription;RNA;RNA-Directed DNA Polymerase;Series;single molecule;Site;skills;small hairpin RNA;Somatic Cell;symposium;targeted cancer therapy;Techniques;Telomerase;Telomerase inhibition;Telomerase Inhibitor;Telomerase RNA Component;telomere;telomere loss;Telomere Maintenance;Telomere Shortening;Testing;Therapeutic;therapeutic target;thiopurine;Time;Toxic effect;Training;tumor;tumor xenograft;Variant;Visualization;Writing

PROJECT_TITLE: Investigating how chemotherapeutic thiopurines inhibit telomerase elongation of telomeres


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Prevention;Rural Health;Social Determinants of Health;Substance Misuse

ORG_CITY: CHAPEL HILL

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative Self-stigma is a key barrier to help-seeking during the opioid epidemic, especially in rural areas, yet there are remarkably few evidence-based interventions to address this phenomenon. The present research uses a behavioral theory-informed, mixed-methods approach to develop and evaluate a novel text message intervention to promote resilience to stigma and reduce feelings of self-stigma among rural people who use drugs. Findings will add to scientific knowledge about feasible and acceptable stigma reduction interventions and provide further evidence of whether text messaging is a productive, cost-effective approach for engaging this hard-to-reach population.

PI_NAMEs: SIBLEY, ADAMS LONGSTREET (contact)

PROGRAM_OFFICER_NAME: JENKINS, RICHARD A

PROJECT_TERMS: acceptability and feasibility;Address;American;Anxiety;Attitude;Behavioral;behavioral health;Belief;career;Characteristics;Classification;Cognitive;cohort;Communicable Diseases;Communication;Competence;coping;Coping Skills;cost effective;COVID-19 pandemic;Data;design;Development;Drug usage;Drug user;Education;Effectiveness;Effectiveness of Interventions;empowerment;Epidemic;Evidence based intervention;experience;Feeling;follow-up;Fright;Funding;Gender;Goals;Harm Reduction;Health;Health behavior;Health behavior change;health communication;Health Personnel;help-seeking behavior;HIV;HIV/AIDS;improved;internalized stigma;Intervention;Intervention Studies;Intervention Trial;Interview;Knowledge;Learning;Life;Literature;Mental Depression;Mental disorders;Mentorship;Methods;Modality;Morbidity - disease rate;mortality;National Institute of Drug Abuse;novel;Ohio;Opioid;opioid epidemic;Overdose;Overdose reduction;Pharmaceutical Preparations;pilot trial;Population;preference;prevent;Preventive;Productivity;promote resilience;psychologic;psychosocial;psychosocial outcome;Publications;Quality of life;Recovery;Recovery Support;Research;Research Personnel;Resistance;Risk Factors;Rural;rural area;Rural Population;Sampling;Self Efficacy;service intervention;Site;skills;social contact;Social isolation;social stigma;sociodemographics;Stereotyping;Stigmatization;Subgroup;substance use;Substance Use Disorder;Techniques;Text Messaging;text messaging intervention;theories;Thinking;Time;Training;uptake;Work

PROJECT_TITLE: Determining the Feasibility and Acceptability of a Novel Stigma Resistance Text Message Intervention for People who Use Drugs

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F16-L(20)L]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;HIV/AIDS;Heart Disease;Infectious Diseases;Pediatric

ORG_CITY: CHICAGO

ORG_NAME: LURIE CHILDREN'S HOSPITAL OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Cardiovascular disease (CVD) is a significant concern in adults living with HIV on antiretroviral therapy (ART), but not much is known about early upstream CVD pathogenesis in youth living with perinatally acquired HIV (YPHIV) who stand to benefit the most from early identification of subclinical CVD. Detailed sensitive imaging data to comprehensively measure myocardial dysfunction, deformational abnormalities, and vascular dysfunction as well as information on metabolic pathways involved in these cardiovascular processes are needed in YPHIV. We will perform cardiac magnetic resonance imaging and metabolomics techniques which will elucidate key metabolic pathways of cardiac dysfunction and inform public health prevention strategies against CVD by identifying those YPHIV at increased risk for the future development of CVD.

PI_NAMEs: JAO, JENNIFER  (contact);ZAR, HEATHER JOY

PROGRAM_OFFICER_NAME: COADY, SEAN

PROJECT_TERMS: Acids;acylcarnitine;Address;Adolescent;Adult;Africa South of the Sahara;Age;Anti-Retroviral Agents;antiretroviral therapy;Biological;Blood Vessels;Body Surface Area;C-reactive protein;cardiac magnetic resonance imaging;cardiometabolism;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;Cardiovascular system;Child;cohort;comparison group;Data;Development;dietary;Dyslipidemias;Early identification;Eicosanoid Production;Eicosanoids;endothelial dysfunction;experience;Exposure to;fatty acid oxidation;Functional disorder;Funding;Future;Heart failure;high risk;HIV;Hydroxyeicosatetraenoic Acids;Image;immune activation;immunomodulatory therapies;Individual;Inflammation;Inflammatory;insight;Insulin Resistance;interest;Interleukin-6;Intervention;Life;Magnetic Resonance Imaging;Measures;Metabolic;Metabolic Pathway;metabolomics;Methods;Mitochondria;mitochondrial dysfunction;mortality;Muscle Cells;Myocardial;Myocardial dysfunction;National Heart, Lung, and Blood Institute;novel;Pathogenesis;Pathway interactions;pediatric human immunodeficiency virus;Perinatal;perinatal HIV;Permeability;Prevention strategy;Process;Public Health;Research Infrastructure;Risk;Role;sex;South African;systemic inflammatory response;Techniques;Time;time use;United States National Institutes of Health;Vascular Diseases;Ventricular;Youth

PROJECT_TITLE: Understanding Inflammatory and Metabolic Pathways of Myocardial and Vascular Dysfunction in South African Youth Living with Perinatal HIV


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Prevention;Social Determinants of Health;Women's Health Research

PHR: NARRATIVE Poor cardiovascular health (CVH) contributes greatly to maternal morbidity and mortality in the United States, and many families enrolled in home visiting are at risk for poor CVH. Improving CVH requires focusing on CVH risk factors, 2-generation strategies addressing mothers and children, and greater use of settings where families already receive care. The Johns Hopkins Early Intervention to Promote Cardiovascular Health of Mothers and Children (ENRICH) Resource and Coordinating Center will generate rigorous, innovative, timely and actionable new knowledge to promote CVH and reduce CVH disparities in mothers and young children.

PI_NAMEs: COOPER, LISA A;EHRHARDT, STEPHAN ;MINKOVITZ, CYNTHIA S (contact)

PROGRAM_OFFICER_NAME: PRATT, CHARLOTTE A

PROJECT_TERMS: Address;Applied Research;behavior test;Behavior Therapy;Biometry;Cardiovascular Diseases;cardiovascular health;care seeking;Caring;Child;Clinical;clinical center;clinical practice;clinical research site;clinical trial protocol;Clinical Trials;Communities;Data;Death Rate;design;Discipline of Nursing;Disparity;disparity reduction;dissemination science;early childhood;Early Intervention;Effectiveness;Effectiveness of Interventions;effectiveness testing;Emerging Technologies;Enrollment;Epidemiology;Ethnic Origin;evidence base;Expectancy;experience;Family;forging;Funding;Generations;Geographic Locations;Geography;health disparity;health equity;health of the mother;Health Promotion;Heterogeneity;high risk;Home visitation;Implementation readiness;implementation science;implementation strategy;improved;Individual;Infant;Infrastructure;innovation;Intervention;intervention effect;Investments;Knowledge;Leadership;Life Cycle Stages;lifestyle intervention;maternal morbidity;Maternal Mortality;Mediator;Medicine;member;Methods;mHealth;Modeling;Morbidity - disease rate;mortality;Mothers;Multi-Institutional Clinical Trial;multidisciplinary;National Heart, Lung, and Blood Institute;Obesity;Outcome Assessment;personalized approach;Policies;Preventive service;Primary Care;programs;Protocols documentation;Public Health;racial health disparity;Reduce health disparities;Reporting;Research;research and development;Research Design;Research Personnel;Resources;Risk;Risk Factors;Rural Community;scale up;service delivery;Services;Site;skills;Socioeconomic Status;Structure;success;Techniques;telehealth;Testing;Training;Translating;Translations;tribal community;United States;United States National Institutes of Health;Urban Community;Woman;Work

PROJECT_TITLE: Early Intervention to Promote Cardiovascular Health of Mothers and Children (ENRICH) Multisite Resource and Coordinating Center


PI_NAMEs: YILMAZ, OMER  (contact)

PROJECT_TERMS: Bioinformatics;Biological Markers;Budgets;Cancer Center Support Grant;Cells;Chromosome Mapping;Collaborations;Communities;Computer software;Consultations;Development;Devices;Diagnosis;Diagnostic;digital;digital imaging;Drug Delivery Systems;drug efficacy;Education;Educational workshop;efficacy evaluation;Equipment;Event;Experimental Designs;Funding;Gene Expression;Genes;Genomics;Histologic;Histology;Image Analysis;Immune response;Immunohistochemistry;in vivo;Information Centers;instrumentation;International;investigator training;Malignant Neoplasms;member;Methodology;Methods;Microtome - medical device;Mission;model organism;Molecular;Monitor;Mus;Mutation;nanomaterials;nanoparticle;neoplasm immunotherapy;Neoplasm Metastasis;Oncogenes;Paraffin;Pathologist;Pathology;Pathway interactions;Pharmaceutical Preparations;Phenotype;Preparation;Prevention;programs;Protocols documentation;Research;Research Personnel;Research Support;Resource Sharing;Resources;response;Role;sample collection;Sampling;Scanning;Services;Slide;Source;Stains;success;Technology;Therapeutic;therapeutic target;Tissues;tool;Training;training opportunity;treatment response;tumor;tumor diagnosis;tumor initiation;tumorigenesis;Tumorigenicity;Update;vaccine delivery;Zebrafish

PROJECT_TITLE: Histology


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Networking and Information Technology R&D (NITRD)

PI_NAMEs: IRVINE, DARRELL J (contact)

PROJECT_TERMS: Biochemistry;Budgets;Cancer Center Support Grant;Cells;Cellular biology;Collaborations;confocal imaging;Consultations;data acquisition;Data Analyses;detector;Development;Device or Instrument Development;diagnostic strategy;Education;Educational workshop;Experimental Designs;Funding;Goals;Healthcare;Human Resources;Image;Image Analysis;image processing;Imaging Device;imaging platform;imaging system;Imaging technology;improved;Information Centers;Institution;instrument;instrumentation;interest;intravital imaging;Knowledge;light microscopy;light transmission;Machine Learning;Malignant Neoplasms;member;Methods;Microscope;Microscopy;Mission;Modification;Molecular;Monitor;nanoparticle;Positioning Attribute;programs;recruit;Research;Research Personnel;Resource Sharing;Resources;response;Sampling;Series;Services;Silicon;single molecule;software development;Source;success;Technology;technology platform;Tissues;Training;training opportunity;tumor;ultra high resolution;Visualization

PROJECT_TITLE: Microscopy


PHR: Growth and reproduction of bacteria is vital to their ability to impact human health, and growth is regulated to allow bacterial survival in the face of stresses like antibiotics or starvation. Our research focuses on fundamental, conserved processes central to bacterial reproduction and adaptation to changing growth conditions with the goal of informing development of novel antibiotics and our understanding of antibiotic resistance mechanisms.

PI_NAMEs: GOLEY, ERIN D (contact)

PROGRAM_OFFICER_NAME: BLATCH, SYDELLA ANNE

PROJECT_TERMS: Address;Anti-Bacterial Agents;Antibiotic Resistance;Antibiotics;Bacteria;bacterial genetics;Biochemical;Biochemistry;Caulobacter;Caulobacter crescentus;Cell division;Cell Wall;Cells;Development;Ensure;environmental change;Genetic;Genetic Transcription;Genomics;Goals;Growth;Guanosine Triphosphate Phosphohydrolases;Health;Human;Image;In Vitro;Laboratories;Maps;Metabolism;model organism;novel;Nutrient;Nutrient availability;pathogenic bacteria;Pathway interactions;Process;reconstitution;Regulation;Reproduction;Research;resistance mechanism;Role;scaffold;Signal Pathway;Signal Transduction;Starvation;Stress;transcriptional reprogramming;Work

PROJECT_TITLE: Local and global regulation of bacterial growth


PI_NAMEs: HAMMOND, PAULA T (contact)

PROJECT_TERMS: Area;Biocompatible Materials;Biological Markers;Budgets;Cancer Center Support Grant;cancer prevention;Capital Financing;Chemicals;Collaborations;combinatorial;Consultations;Cryoelectron Microscopy;data acquisition;Data Analyses;Detection;Development;Devices;Education;Educational workshop;Electron Microscope;Ensure;Equipment;Experimental Designs;Fluorescence;Freeze Fracturing;Freeze Substitution;Funding;Goals;Image;image processing;imaging modality;imaging system;Imaging technology;Information Centers;Institution;instrument;instrumentation;interest;Ions;Light;Machine Learning;Mechanics;member;Methods;microscopic imaging;Mission;nanoformulation;nanoparticle;Nanotechnology;novel strategies;Preparation;pressure;programs;Property;Protocols documentation;rational design;Research;Research Personnel;Resolution;Resource Sharing;Resources;response;Sampling;Scanning;Scanning Probe Microscopes;Series;Services;Source;Specialist;Spectrum Analysis;Structure;success;Surface;System;targeted treatment;Technology;technology platform;Time;tool;Training;training opportunity;ultra high resolution;Vaccines;Visualization;Wages

PROJECT_TITLE: Nanotechnology Materials


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Genetics

ORG_CITY: NEW YORK

ORG_DEPT: BIOLOGY

ORG_NAME: COLUMBIA UNIV NEW YORK MORNINGSIDE

PHR: Project Narrative  Defects in pre-mRNA processing are linked to human diseases, and recent reports show that the endonuclease for this processing (CPSF73) could be a target for anti- cancer and anti-protozoan agents. Our studies will contribute to understanding the molecular mechanism for mRNA processing, stability and degradation.

PI_NAMEs: TONG, LIANG  (contact)

PROGRAM_OFFICER_NAME: CZAPLINSKI, KEVIN

PROJECT_TERMS: anti-cancer;Biochemical;Cell Nucleus;Cells;Cleavage And Polyadenylation Specificity Factor;cleavage factor;Cleavage Stimulation Factor;Coenzyme A;Complex;Cryoelectron Microscopy;Crystallography;Cytoplasm;Defect;endonuclease;Enzymes;Event;experimental study;Family;Fibrinogen;Foundations;Funding;Genetic Transcription;Goals;Histones;Human;human disease;Knowledge;Life Cycle Stages;Link;Mammals;Messenger RNA;Molecular;Molecular Mechanisms of Action;mRNA capping;mRNA Precursor;Nucleotides;Polyadenylation;Polymerase;Protein Family;Proteins;Prothrombin;Quality Control;reconstitution;Reporting;RNA;RNA Polymerase II;RNA Splicing;Small Nuclear RNA;stem;Structure;success;Yeasts

PROJECT_TITLE: Structural and functional studies of mRNA processing, stability and quality control

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-V(55)R]


NIH_SPENDING_CATS: Cancer

PI_NAMEs: VANDER HEIDEN, MATTHEW G. (contact)

PROJECT_TERMS: academic review;Administrative Coordination;Annual Reports;Biology;Budgets;Businesses;Cancer Center;Cancer Center Support Grant;Collaborations;Communities;Core Facility;Development;Ensure;Evaluation;Evaluation Research;Faculty;Financial Support;Future;Grant;Individual;Industry;Laboratories;Leadership;Link;meetings;member;Process;programs;Reporting;Research;Research Support;Resource Sharing;Review Committee;Science;Scientist;Series;Site;Structure;Visit

PROJECT_TITLE: Leadership, Planning and Evaluation


NIH_SPENDING_CATS: Neurosciences

ORG_CITY: WASHINGTON

ORG_NAME: SOCIETY FOR NEUROSCIENCE

ORG_STATE: DC

PHR: A diverse, well-trained neuroscience workforce is instrumental to making new discoveries about how the brain works and to finding innovative ways to prevent and treat neurological illnesses affecting nearly 100 million Americans and costing $800 billion annually (Gooch et al., 2017). Diversity in the neuroscience workforce also ensures that discoveries apply to a broader spectrum of the U.S. population as involvement of researchers from underrepresented groups has significantly increased attention to and research on health disparities and otherwise-neglected issues specific to women’s health and those of diverse populations (Tabak, 2012). By supporting diverse neuroscientists at various career stages, the Neuroscience Scholars Program (NSP) fosters and grows a diverse neuroscience workforce that will efficiently address a breadth of difficult research questions and adopt a range of approaches that may not be imagined by a group with homogeneous backgrounds and training.

PI_NAMEs: POE, GINA R;ROSA-MOLINAR, EDUARDO  (contact)

PROGRAM_OFFICER_NAME: JONES, MICHELLE

PROJECT_TERMS: Academia;Acceleration;Achievement;Address;Adopted;Affect;American;Applications Grants;Attention;Brain;career;career development;Career Mobility;career networking;cohort;Communities;community building;cost;Development;Disabled Persons;Diverse Workforce;Educational Activities;Educational Curriculum;Educational workshop;Elements;Employment;Enrollment;Ensure;Ethnic Population;Evaluation Studies;Event;experience;Feedback;Financial Support;Fostering;Funding;Goals;graduate student;Grant;health disparity;improved;Industry;innovation;Institution;Journals;Knowledge;Lead;Leadership;leadership development;Learning;meetings;Mentors;Mentorship;neglect;Neurologic;Neurosciences;Neurosciences Research;next generation;online community;Participant;Peer Review;Persons;Population;Population Heterogeneity;Positioning Attribute;Postdoctoral Fellow;prevent;programs;Publications;Publishing;racial population;Recording of previous events;Research;Research Activity;Research Personnel;Resources;Role;role model;Scholars Program;skills;social integration;Societies;success;Support System;symposium;Training;Training Activity;Travel;Underrepresented Populations;Universities;webinar;Women's Health;Work;Writing

PROJECT_TITLE: Neuroscience Scholars Program (NSP): Preparing the Next Generation of Neuroscience Leaders


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: STANFORD

ORG_DEPT: CHEMISTRY

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative By combining new methods for three-dimensional high precision optical imaging in living cells with careful analysis of how single-molecule labels interact with light, this research will yield develop and validate a powerful three-dimensional microscope both for super-resolution imaging as well as single-particle tracking in living cells, and the advanced imaging capability will be applied to the understanding of the numerous nanometer-sized machines such as enzymes and proteins which interact in complex ways with DNA and RNA in the cell. Having unprecedented and highly quantitative spatial information about the structures and motion of RNA, DNA loci, protein superstructures, or other biomolecules in cells down to the 10-20 nm level of precision in three dimensions with high time resolution will directly affect the understanding of biotechnological and biomedical problems which depend upon natural or aberrant cellular mechanisms. The ability to specifically and noninvasively measure high resolution structure (i.e. optically and also correlated with electron microscopy) as well as to record precise time-dependent positions of key biomolecules in live cells will have strong implications for biomedical imaging and understanding of both bacterial cell mechanisms as well as mammalian cells whose internal structures and behavior are altered in the progress of disease.

PI_NAMEs: MOERNER, WILLIAM E (contact)

PROGRAM_OFFICER_NAME: YEH, ALVIN TIEN-WEI

PROJECT_TERMS: 3-Dimensional;Address;Affect;Bacteria;Behavior;Biological Models;biomedical imaging;Biotechnology;Caulobacter crescentus;cell behavior;Cells;Cellular biology;cellular development;cellular imaging;Chromatin;Collaborations;Complex;Cryo-electron tomography;cryogenics;Dependence;Development;Disease;DNA;Electron Microscopy;Environment;Enzymes;fascinate;Fluorescence;fluorescence imaging;Fluorescence Microscopy;high dimensionality;Image;imaging capabilities;imaging modality;invention;Label;Laboratories;Light;Mammalian Cell;mathematical analysis;Measurement;Measures;Methodology;Methods;Microscope;Motion;Motivation;Motor;nanomachine;nanoscale;Oligonucleotides;optical imaging;Optics;Organism;Parasites;particle;Phase;Positioning Attribute;programs;Proteins;Pupil;reconstruction;Research;research and development;Research Methodology;Resolution;RNA;single molecule;small molecule;Speed;Structure;superresolution imaging;superresolution microscopy;Three-Dimensional Imaging;Time;tool;Toxoplasma gondii;ultra high resolution;Work

PROJECT_TITLE: Single-Molecule Imaging for Cell Biology and Super-Resolution Microscopy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-D(55)R]


PROJECT_TERMS: Area;Cancer Center Support Grant;career development;Categories;Core Facility;cost;Development;Engineering;Equilibrium;equipment acquisition;Evaluation;Faculty;Faculty Recruitment;flexibility;Funding;Future;Goals;instrumentation;Laboratories;Mediation;member;new technology;Play;Process;recruit;Research Personnel;response;Science;Services;Shapes;Teacher Professional Development;Technology;Wages

PROJECT_TITLE: Developmental Funds


PROJECT_TERMS: anti-cancer research;Calendar;Cancer Center;Cancer Center Support Grant;career;career development;Clinical Investigator;Communities;Core Facility;Educational process of instructing;Educational Status;Educational workshop;Faculty;faculty mentor;Fellowship;Festival;graduate student;Grant;High School Student;immunoengineering;International;junior high school;Knowledge;Laboratories;Laboratory Research;Leadership;leadership development;Learning;lectures;Malignant Neoplasms;Manuscripts;Mediation;member;Mentors;Mission;next generation;novel;Occupations;Oncology;Physicians;Positioning Attribute;Postdoctoral Fellow;precision oncology;Preparation;programs;Research Personnel;Role;Science;Scientist;senior faculty;Series;student participation;Students;summer institute;summer research;Supervision;symposium;Training;training opportunity;Training Programs;Travel;undergraduate research experience;undergraduate student;Vision

PROJECT_TITLE: Cancer Research CareerEnhancement and Related Activities


ORG_CITY: TAMPA

ORG_NAME: H. LEE MOFFITT CANCER CTR & RES INST

ORG_STATE: FL

PHR: Publlc health statement By enforcing close collaboration between experimental and computational biologists from early phases of experimental design and data collection, CLONEID will help ameliorate the reproducibility crisis in cancer biology. Our framework represents an early step towards leveraging ongoing in-vitro evolution as an opportunity, not a burden. Because durable success in the clinical setting cannot be achieved without an experimental setting in which our solutions are repeatedly challenged with the adaptive nature of cancer.

PI_NAMEs: ANDOR, NOEMI  (contact)

PROGRAM_OFFICER_NAME: MILLER, DAVID J

PROJECT_TERMS: Adopted;Back;Behavior;Biological;Biological Assay;Biological Markers;Biopsy;Cancer Biology;Cancer cell line;cancer heterogeneity;carcinogenesis;Carrying Capacities;Cell Count;Cell Culture Techniques;Cell division;Cell Line;Cell Lineage;Cells;Clinical;Clinical Trials;Collaborations;Complex;Computer Analysis;Computer software;Computer Vision Systems;contrast imaging;cost;Crystallization;Data;Data Collection;Databases;DNA;driver mutation;Drug Screening;Early Diagnosis;Engineering;Environment;environmental adaptation;environmental change;Equipment;Evolution;Exhibits;experimental analysis;Experimental Designs;experimental study;Failure;fitness;flexibility;Foundations;Future;Generations;Genetic;genetic pedigree;Genetic Transcription;Genome;Genomic Instability;Genotype;Growth;Habits;Harvest;Health;Heterogeneity;high throughput screening;Image;In Vitro;in vivo;Individual;Java;Laboratory Research;Laws;Link;live cell imaging;Malignant Neoplasms;malignant stomach neoplasm;mathematical model;Mathematics;Measurement;Methodology;Modeling;Monitor;Morphology;multiple omics;Mycoplasma;Nature;Nutrient;Oncology;Pathway interactions;Periodicals;Pharmaceutical Preparations;Phase;Phenotype;Population;pre-clinical;Primary Neoplasm;Proteome;Protocols documentation;prototype;Publishing;Reagent;Reproducibility;Research Personnel;Resolution;response;Scientist;Silicon Dioxide;single cell sequencing;single-cell RNA sequencing;specific biomarkers;success;System;temporal measurement;Testing;Time;transcriptome;transcriptome sequencing;tumor

PROJECT_TITLE: Engineering model-based systems to monitor and steer subclonal dynamics


NIH_SPENDING_CATS: Genetics;Infectious Diseases

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: RELEVANCE: The mechanistic and structural studies of diverse nucleic acid transactions proposed for the MIRA renewal have relevance for human physiology and pathophysiology insofar as: (i) tRNA splicing enzymes Trl1 and Tpt1 are promising drug discovery targets for treatment of fungal infections; (ii) RNA ligase RtcB is a central agent of the unfolded protein response to cellular stress; and (iii) metabolite control of RNA 3’- processing and transcription termination by inositol pyrophosphate 1,5-IP8 highlights a new level of gene regulation in eukarya.

PI_NAMEs: SHUMAN, STEWART H (contact)

PROGRAM_OFFICER_NAME: SIMONOVIC, MILJAN

PROJECT_TERMS: anti-fungal agents;Archaea;Bacteria;Bacteriophage T4;Biochemistry;Biological Models;Cell Physiology;Cells;Cellular Stress;Code;cofactor;Complex;Diphosphates;DNA;drug discovery;enzyme structure;Enzymes;Event;Family;Fission Yeast;Functional disorder;fungus;Gene Expression;Gene Expression Regulation;gene repression;Genetic;Genetic Transcription;Goals;Guanosine Triphosphate;Homeostasis;Human;Human Genome;Immune response;inorganic phosphate;Inositol;Ligase;Mediating;Messenger RNA;Microbiology;Modification;Mycoses;Normal Cell;Nucleic Acids;Nucleotides;Pathway interactions;Phosphotransferases;Phylogenetic Analysis;Physiology;promoter;Proteins;pyrophosphatase;Reaction;Regulation;Regulon;repair enzyme;repaired;Repression;Research;response;Retrotransposition;RNA;RNA Ligase (ATP);RNA Splicing;Signaling Molecule;Specificity;structural biology;Structure;System;tool;TPT1 gene;transcription termination;Transfer RNA;tRNA Ligase;Virus;Virus Diseases

PROJECT_TITLE: Mechanisms of DNA and RNA Transactions

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MGG-C(55)R]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Dementia;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Prevention

ORG_CITY: PULLMAN

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: WASHINGTON STATE UNIVERSITY

ORG_STATE: WA

PHR: PROJECT NARRATIVE We propose to build a multidisciplinary research and mentoring program that will design wearable sensing and pervasive computing technologies to improve detection, assessment and intervention for individuals with Alzheimer's disease and related dementias (ADRDs). Built on a foundation of existing research and mentoring collaboration between computer science and neuropsychology, we will design and validate methods to analyze the relationship between ADRDs and behavior. We will create robust health-predictive models from longitudinal sensor data collected in naturalistic settings and will connect health and behavior with multiple influences, such as genetics and environment, to advance quality of care and reduce functional disability associated with ADRDs.

PI_NAMEs: COOK, DIANE JOYCE (contact);SCHMITTER-EDGECOMBE, MAUREEN

PROGRAM_OFFICER_NAME: LUO, YUAN

PROJECT_TERMS: Address;Alzheimer's disease related dementia;Area;automated intervention;Behavior;built environment;career;Clinical Research;Cognitive;Collaborations;computer science;Computing Methodologies;cost;Data;data integration;design;Detection;digital;Environment;Ethnic Origin;experience;Foundations;functional disability;Generations;Genetic;graduate student;Health;health assessment;Health behavior;Health Care Costs;Human;improved;Individual;innovation;insight;Institution;Interdisciplinary Study;Intervention;Link;Machine Learning;Maps;Measures;medication compliance;Memory;Mentors;Methods;Modeling;multidisciplinary;Neuropsychology;novel;Pattern;Performance;Persons;Population Heterogeneity;predictive modeling;programs;Quality of Care;Quality of life;Recording of previous events;recruit;Research;Research Personnel;Resources;sensor;Series;smart home;Source;student training;Technology;Training;Underrepresented Populations;United States National Institutes of Health;wearable data;wearable device;wearable sensor technology;webinar;Work

PROJECT_TITLE: Creating adaptive, wearable technologies to assess and intervene for individuals with ADRDs


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Neurodegenerative;Neurosciences;Parkinson's Disease;Physical Injury - Accidents and Adverse Effects;Rare Diseases;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_DEPT: PATHOLOGY

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: Narrative Over 15 million contact sports players and military veterans are at risk for the development of chronic traumatic encephalopathy (CTE), a neurodegenerative disease associated with exposure to repetitive head trauma that features a parkinsonian phenotype, although very little is understood about how these individuals develop parkinsonism. We will compare the p-tau pathology, neuroinflammation, and microvascular alterations in brain motor regions in CTE to progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD), and determine the contribution of these changes to parkinsonism. The proposed research is relevant to public health because it will increase our understanding of the effects of repetitive trauma on the development of parkinsonism in CTE and relevant to NIH’s mission to develop novel diagnostic and prognostic biomarkers and therapies to lessen the morbidity and mortality of neurodegenerative disease.

PI_NAMEs: KIRSCH, DANIEL A (contact)

PROGRAM_OFFICER_NAME: UMOH, NSINI ALEASE

PROJECT_TERMS: Address;Astrocytes;Autopsy;Basal Ganglia;behavior change;Binding;biomarker identification;Blood Vessels;Brain;brain tissue;Cd68;cell type;Cells;chronic traumatic encephalopathy;Clinic;Clinical;Clinical Data;cohort;contact sports;corticobasal degeneration;Craniocerebral Trauma;Cytopathology;Data;Dentate nucleus;Deposition;Development;Diagnosis;diagnostic biomarker;Disease;Disease stratification;Dopaminergic Cell;dopaminergic neuron;dosage;Dose;effective therapy;Etiology;experience;Exposure to;Extravasation;Fibrinogen;Fibroblast Growth Factor;Fresh Tissue;Glial Fibrillary Acidic Protein;Goals;head impact;hyperphosphorylated tau;ICAM1 gene;Immunoassay;Immunohistochemistry;Impaired cognition;indexing;Individual;Inflammation;Inflammatory;inflammatory marker;informant;Interview;Knowledge;Label;Life;Link;Measures;Microscopy;Microtubules;microvascular pathology;military service;military veteran;Mission;Moods;Morbidity - disease rate;mortality;Motor;Motor Cortex;Nerve Degeneration;Neurodegenerative Disorders;neuroinflammation;Neurons;neuropathology;novel diagnostics;Oligodendroglia;Parkinsonian Disorders;pars compacta;Pathologic;Pathology;Pattern;persistent symptom;Phenotype;Play;Populations at Risk;Positioning Attribute;Prognostic Marker;Progressive Supranuclear Palsy;Protein Isoforms;Proteins;Proteomics;Public Health;Recording of previous events;Red nucleus structure;Research;Resources;Risk;Role;Serum Albumin;Spatial Distribution;Stains;Standardization;Structural defect;Substantia nigra structure;Symptoms;tau aggregation;tau Proteins;tau-1;Tauopathies;Techniques;Testing;therapeutic target;therapeutically effective;Tissues;Trauma;Traumatic Brain Injury;Tyrosine 3-Monooxygenase;United States National Institutes of Health;vascular abnormality;Vascular Endothelial Growth Factors;vascular inflammation;vascular injury;Work

PROJECT_TITLE: Tau Pathology in Motor Regions and Parkinsonism in Chronic Traumatic Encephalopathy: A Comparison to Progressive Supranuclear Palsy and Corticobasal Degeneration


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Genetics;Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: SYRACUSE

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UPSTATE MEDICAL UNIVERSITY

PHR: Transient amplifying intermediate neural progenitor cells (INPs) are critical for generating brain complexity. Defects in generating INPs can result in severe developmental neurological disorders such as microcephaly and cortical malformations, whereas defects in fate commitment and subsequence dedifferentiation of INPs can lead to brain tumor formation. Therefore, deciphering molecular mechanisms that control INP generation will not only help us understand how various neurodevelopmental disorders and brain tumors develop, but may also provide much needed knowledge for designing novel therapeutic treatments for these neurological diseases.

PI_NAMEs: ZHU, SIJUN  (contact)

PROGRAM_OFFICER_NAME: RIDDLE, ROBERT D

PROJECT_TERMS: 3' Untranslated Regions;Affect;Back;BHLH Protein;Binding;Biological Models;Brain;Brain Neoplasms;Cancer Biology;cell dedifferentiation;Cell Maturation;Cells;Complex;Cortical Malformation;Data;Defect;design;Development;developmental disease;developmental neurobiology;Drosophila genus;Earmuff;Ectopic Expression;Endosomes;Ensure;Epigenetic Process;Family;Feedback;Ganglia;Generations;Genes;Genetic;Genetic Transcription;Glioblastoma;Goals;Grant;Homologous Gene;Human;knock-down;Knowledge;Malignant Neoplasms;Mediating;Messenger RNA;Microcephaly;Molecular;Mothers;nerve stem cell;Nervous System Disorder;neuroblast;Neurodevelopmental Disorder;Neuroglia;Neurons;notch protein;novel;novel therapeutics;Nuclear Export;Numbness;Pathogenesis;Phenotype;Post-Transcriptional Regulation;posttranscriptional;premature;prevent;Process;programs;Proliferating;Reporter;Repression;RNA-Binding Proteins;Role;self-renewal;Signal Transduction;Specific qualifier value;stem cell biology;Stem Cell Development;stem cells;Study models;Testing;trafficking;transcription factor;Transcriptional Regulation;Translations;Tumor Suppressor Proteins;tumorigenic;Untranslated Regions

PROJECT_TITLE: Generation of Intermediate Neural Progenitors in Drosophila Larval Brains

STUDY_SECTION: NCF

STUDY_SECTION_NAME: Neurogenesis and Cell Fate Study Section[NCF]


NIH_SPENDING_CATS: Amyotrophic Lateral Sclerosis (ALS);Bioengineering;Biotechnology;Brain Disorders;Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: SEATTLE

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: Project Narrative There is a great need for non-invasive methodologies to delivery drugs to treat nervous system diseases. The goal of this project is to optimize CNS targeting-peptides to provide a catalog of vehicles that can be paired and custom tailored for targeting biologics delivery into aged and ALS mice. With the goal of designing materials for pre- clinical testing in a model of ALS, we build upon a peptide-ligand, TAxI, to optimize drug conjugated copolymers and to develop a human TAxI-peptide for translatable CNS delivery formulations. We expect these novel therapeutics will significantly impact the treatment of Nervous System Disorders.

PI_NAMEs: SELLERS, DREW L (contact)

PROGRAM_OFFICER_NAME: RANGANATHAN, SRIKANTH

PROJECT_TERMS: Acceleration;Affinity;Age;aged;Aging;Amino Acid Substitution;Amino Acids;Amyotrophic Lateral Sclerosis;amyotrophic lateral sclerosis therapy;Antibodies;Autonomic Dysfunction;Autonomic nervous system;Avidin;Avidity;Bacteriophages;Binding;Binding Proteins;Biodistribution;Biological;Biological Availability;Biological Products;Blood;Blood - brain barrier anatomy;blood-brain barrier disruption;Brain;Brain-Derived Neurotrophic Factor;Catalogs;Cells;Central Nervous System;Central Nervous System Agents;Central Nervous System Diseases;Cerebral endothelium;Cessation of life;Clinic;clinical translation;copolymer;Coupled;Custom;Cyclization;Data;design;Development;Diagnosis;Digestion;Disease;Disease Progression;Dose;Drug Delivery Systems;Drug Modelings;Drug Targeting;Engineering;Equus caballus;Formulation;Gel;glial cell-line derived neurotrophic factor;Goals;Histologic;Homologous Gene;Human;improved;In Vitro;in vivo;Individual;Induced pluripotent stem cell derived human neuron;Intramuscular Injections;Intraperitoneal Injections;Ligands;lipophilicity;macromolecule;Mass Spectrum Analysis;Mediating;Metabolism;Methodology;Methods;Modeling;Modification;Molecular Structure;Monitor;Motor Neurons;mouse model;Mus;Muscular Atrophy;Nerve Degeneration;Nerve Growth Factors;Nervous System Disorder;neural;Neuromuscular Diseases;Neurons;neurotrophic factor;new technology;next generation sequencing;non-invasive system;novel;novel therapeutics;Organ;Pathway interactions;Patients;Penetrance;Peptide Hydrolases;peptide structure;Peptide Synthesis;Peptides;Peripheral;Persons;Pharmaceutical Preparations;polymerization;Polymers;pre-clinical research;Preclinical Testing;premature;Proteins;Rabies virus;receptor;receptor binding;Research;Resistance;scaffold;sciatic nerve;Serum;side effect;Spinal Cord;Structure;success;systemic barrier;targeted delivery;targeted treatment;Therapeutic;therapeutic development;therapeutically effective;Tissues;Toxic effect;transcytosis;Translating;translational therapeutics;Translations;United States;uptake;Virus Diseases

PROJECT_TITLE: Multimeric Peptide Copolymer Formulations for Targeted Drug Delivery to Treat Nervous System Disorders

STUDY_SECTION: DDNS

STUDY_SECTION_NAME: Drug Discovery for the Nervous System Study Section[DDNS-R]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Cerebrovascular;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: ORANGE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: CHAPMAN UNIVERSITY

PHR: PROJECT NARRATIVE Biologic TNF-α inhibitors (TNFIs) are a potential treatment for Alzheimer’s disease (AD) but do not reach the brain after systemic administration. The current proposal focuses on the development of a brain-penetrating biologic TNFI for AD that can be administered systemically and delivered to the brain non-invasively.

PI_NAMEs: SUMBRIA, RACHITA  (contact)

PROGRAM_OFFICER_NAME: CHAKROBORTY, SHREAYA

PROJECT_TERMS: 3xTg-AD mouse;Address;Advanced Development;Adverse effects;Affinity;Age;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease test;Amyloid beta-Protein;Anemia;Antibodies;Binding;Biologic Development;Biological;Biological Models;Biological Products;Blood - brain barrier anatomy;Blood Vessels;blood-brain barrier disruption;blood-brain barrier function;blood-brain barrier penetration;Brain;Central Nervous System;Central Nervous System Diseases;Cerebral endothelium;cerebral microbleeds;Chemistry;chimeric antibody;Chimeric Proteins;Chronic;Clinical;clinical phenotype;Clinical Trials;Cognitive deficits;Complete Blood Count;Data;Development;Dose;drug development;Engineering;Etanercept;Event;Extracellular Domain;Face;Fc Receptor;Goals;Histology;Human;Ibuprofen;Impaired cognition;improved;Inflammation;inflammatory marker;Literature;Mediating;Memory impairment;molecular trojan horse;mouse model;Mus;neural;neuron loss;neuropathology;NOR Mouse;Oxidative Stress;Parkinson Disease;Pathologic;Pathologic Processes;Penetration;Peripheral;Pharmaceutical Preparations;Play;pre-clinical;Primates;receptor;Reporting;Research Support;response;Role;Route;Serum;side effect;Stroke;Synapses;targeted treatment;tau Proteins;TFRC gene;Therapeutic;Therapeutic Effect;Therapeutic Index;Therapeutic Intervention;Time;Tissues;TNF gene;Toxic effect;transcytosis;Transgenic Mice;Tumor Necrosis Factor Receptor;tumor necrosis factor-alpha inhibitor;White Blood Cell Count procedure;Work;β-amyloid burden

PROJECT_TITLE: A Brain Penetrating Bi-functional Transferrin Receptor Antibody-TNF-alpha Decoy Receptor Fusion Protein for Alzheimer's Disease


ADMINISTERING_IC: AI

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Infectious Diseases

PHR: PROJECT NARRATIVE The arms race between viruses and their host organisms is a key driving force shaping the evolution of all forms of life. This proposal aims to determine the molecular mechanisms driving reciprocal adaptations between bacteriophages and parasitic phage-defense elements in Vibrio cholerae, the causative agent of the severe diarrheal disease cholera. This study will advance our understanding of the factors promoting the evolution of epidemic V. cholerae and help to inform infection control measures for antibiotic-resistant bacterial pathogens.

PI_NAMEs: SEED, KIMBERLEY DIANE (contact)

PROGRAM_OFFICER_NAME: ZEITUNI, AMIR E

PROJECT_TERMS: Address;antagonist;arms race;Automobile Driving;Back;Bacterial Antibiotic Resistance;Bacteriophages;Bangladesh;Biochemical;Biological Assay;Biological Models;Cause of Death;Cholera;Collection;Conflict (Psychology);Dangerousness;Depressed mood;diarrheal disease;Disease;driving force;Dysentery;Elements;Epidemic;Evolution;Extinction;Genetic;Genetic Recombination;Genome;Genomic Instability;Genomics;Genotype;Geography;Goals;Human;human disease;In Vitro;in vivo;Incidence;Infection;Infection Control;insight;Integrase;Intestines;Island;Knowledge;Laboratories;Left;Life;Life Cycle Stages;Link;Measures;Mediating;microbial;Mobile Genetic Elements;Molecular;Monitor;Natural Disasters;novel;nuclease;Organism;pandemic disease;Parasites;pathogen;pathogenic bacteria;Patients;Pattern;Population;Positioning Attribute;Predatory Behavior;Predisposition;Production;prophylactic;Public Health;Replication Origin;Resources;Role;Shapes;socioeconomic development;Source;stool sample;Study models;System;Testing;Therapeutic;Therapeutic community technique;Time;transmission process;Variant;Vibrio cholerae;Viral;Virus;Work

PROJECT_TITLE: Molecular mechanisms driving the antagonistic coevolution of viral satellites and bacteriophages in Vibrio cholerae

STUDY_SECTION: PCMB

STUDY_SECTION_NAME: Prokaryotic Cell and Molecular Biology Study Section[PCMB]


ORG_CITY: NEW ORLEANS

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: Project Narrative This project is relevant to public health because the discovery of the functioning mechanisms of centromeric transcription is ultimately expected to increase understanding of the underlying causes of the aneuploidy-associated diseases, such as cancer. Thus, this proposed research is relevant to the part of NIH’s mission that pertains to seeking fundamental knowledge that will help to reduce the human illness.

PI_NAMEs: LIU, HONG  (contact)

PROGRAM_OFFICER_NAME: MILLER, RITA K

PROJECT_TERMS: Affect;Aneuploidy;Antineoplastic Agents;base;cancer therapy;Cell Cycle;Cell Cycle Stage;Centromere;Chromatin;Chromosomal Instability;Chromosomal Stability;Chromosome Segregation;Clinical;cohesion;Cyclin-Dependent Kinases;Data;Defect;Deposition;Development;Disease;DNA Sequence;drug discovery;Epigenetic Process;epigenetic regulation;Eukaryota;Future;Gene Expression;Genetic Transcription;Goals;histone modification;Histones;Human;innovation;knock-down;Knowledge;Maintenance;Malignant Neoplasms;Mission;Mitosis;Mitotic;novel;novel strategies;novel therapeutic intervention;Outcome;Pathway interactions;Phosphorylation;Phosphotransferases;Play;Process;Production;Proteins;Public Health;Publishing;Regulation;Research;RNA;RNA Polymerase II;Role;Satellite DNA;Testing;Therapeutic Agents;therapeutic target;tool;Translations;tumorigenesis;United States National Institutes of Health;Untranslated RNA;Variant;Yeasts

PROJECT_TITLE: Functions and Regulation of Centromeric Transcription

STUDY_SECTION: NCSD

STUDY_SECTION_NAME: Nuclear and Cytoplasmic Structure/Function and Dynamics Study Section[NCSD]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Data Science;Networking and Information Technology R&D (NITRD);Pediatric;Social Determinants of Health

ORG_CITY: MADISON

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: The project enriches recently available “big data” on tens of millions of mortality observations in the US for cohorts born in the early 20th century by adding a set of early life exposures of disease, economics, and environments. This allows us to test key hypotheses of the Developmental Origins of Adult Health and Disease as well as generate new hypotheses by assessing how exposures interact, accumulate, and persist across generations.

PI_NAMEs: FLETCHER, JASON MICHAEL (contact);GOLDSTEIN, JOSHUA R.

PROGRAM_OFFICER_NAME: BRAUDT, DAVID BRUCE

PROJECT_TERMS: 1918 influenza pandemic;Accounting;Adult;Affect;Age;Atlases;Back;Big Data;Biology;Birth;Categories;Cause of Death;Censuses;Cessation of life;Child;Childhood;Chronic Disease;cohort;Communicable Diseases;Complex;County;Data;Data Set;Death Rate;Death Records;Demographer;Demography;Development;Disasters;Discipline;Disease;Disparate;early life exposure;Economics;Education;Environment;Environmental Risk Factor;Epidemiologist;Epidemiology;Event;experience;Experimental Designs;Exposure to;Family;follow-up;forest;frontier;Generations;Geographic Locations;Geography;Health;human old age (65+);ICD-9;improved;in utero;infancy;Infant;Infant Mortality;Influenza;Interdisciplinary Study;interest;intergenerational;International Statistical Classification of Diseases and Related Health Problems, Tenth Revision (ICD-10);Knowledge;late life;Life;Life Cycle Stages;Life Expectancy;Link;Machine Learning;Measures;Medical;men;Methods;middle age;Modeling;mortality;Mothers;Natural Disasters;Natural experiment;Neighborhoods;next generation;Occupations;Outcome;Output;pandemic disease;Pattern;Persons;Phase;Population;power analysis;prenatal exposure;Process;Public Health;Research Design;Scientist;Series;sex;sex variable;Shapes;Siblings;social;Socioeconomic Status;sociologist;Stress;Testing;theories;Time;tool;Trees;Variant;Water fluoridation;Woman;Work

PROJECT_TITLE: Uncovering Life Course Constellations of Exposures through Big Data on Place, Time, and Family Factors

STUDY_SECTION: SSPB

STUDY_SECTION_NAME: Social Sciences and Population Studies B Study Section[SSPB]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cardiovascular;Heart Disease;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Nonembryonic - Human

ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: PROJECT NARRATIVE  Stem cell-based regenerative therapies or in vitro investigations of cardiovascular disease pathophysiology, drug screening, and toxicology studies heavily rely on stem cell quality. Here, peptide nanostructures will be engineered to enable cells to be light responsive in a wireless and non-genetic manner, which can ultimately be utilized as a strategy for converting optical cues to stimulatory signals that can improve the structural and functional maturity of human stem cell-derived cardiomyocytes. With this new approach, we hope to alleviate the major technical barrier of CM immaturity, and therefore, better enable stem cell-based cardiovascular research and related fields to flourish.

PI_NAMEs: ARDOÑA, HERDELINE ANN MALLARI (contact)

PROGRAM_OFFICER_NAME: THAKAR, RAHUL GAUTAM

PROJECT_TERMS: Action Potentials;Address;Adult;Animal Model;Anisotropy;Architecture;Automobile Driving;Behavior;Binding;biomaterial interface;Biophysics;Calcium;Cardiac;Cardiac Myocytes;cardiac tissue engineering;Cardiovascular Diseases;Cardiovascular system;Cell Culture Techniques;Cell Survival;Cells;Charge;Chemical Stimulation;chromophore;combinatorial;conditioning;Cues;design;disease mechanisms study;drug discovery;Drug Screening;Electric Stimulation;Electrodes;Engineering;Ensure;Epitopes;extracellular;Film;Frequencies;Functional disorder;Gene Expression;Generations;genetically modified cells;Goals;Heart Diseases;Heart Injuries;Heating;high throughput screening;human induced pluripotent stem cells;human stem cell-derived;improved;In Vitro;indexing;infection risk;innovation;instrumentation;Investigation;irradiation;Light;Measurement;Measures;Mechanics;Mediating;Metabolism;Methods;Microelectrodes;minimally invasive;Modeling;Monitor;monomer;Muscle Cells;Nanostructures;Neonatal;non-genetic;novel strategies;Optics;optogenetics;Pattern;Peptide Library;Peptides;personalized medicine;Phenotype;Polymers;Process;Protocols documentation;Rattus;Reaction;regenerative therapy;Reporting;Research;Resolution;response;Risk Assessment;Risk Reduction;scale up;Side;Signal Transduction;Source;spatiotemporal;species difference;stem;stem cell based approach;stem cells;Stimulus;Stress;Structure;success;Surface;Technology;temporal measurement;Testing;Therapeutic;Tissues;Toxicology;Transducers;Transfection;Ventricular;wireless

PROJECT_TITLE: Optically Promoting Cardiac Maturation Using Engineered Peptides

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: PHILADELPHIA

ORG_NAME: THOMAS JEFFERSON UNIVERSITY

PHR: Project Narrative Uncontrolled activation of the Nlrp3 inflammasome can lead to a number of human inflammatory diseases including arthritis, atherosclerosis, and type 2 diabetes. Understanding the molecular pathways that regulate Nlrp3 activation is of great health relevance and should facilitate the development of new therapeutics to treat inflammatory diseases in which Nlrp3 is involved.

PI_NAMEs: ALNEMRI, EMAD S (contact)

PROGRAM_OFFICER_NAME: PARK, HEIYOUNG

PROJECT_TERMS: 1-Phosphatidylinositol 4-Kinase;Acidity;Anti-Inflammatory Agents;Arthritis;Atherosclerosis;Binding;CASP1 gene;Cations;Cell Death;cell injury;Cell Volumes;Chlorides;Cholesterol;cytokine;Data;Development;Disease;experimental study;Generations;Genetic;Gout;Health;Homeostasis;Human;IL18 gene;in vivo;Infection;Inflammasome;Inflammatory;Inflammatory Response;Innate Immune Response;insight;Interleukin-1 beta;Ions;Laboratories;Ligands;Light;Lysine;Macrophage;marenostrin;Mass Spectrum Analysis;Mediating;microbial;Mitosis;Molecular;Molecular Conformation;Multiprotein Complexes;Natural Immunity;NIMA;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutics;Nucleotides;pathogen;pathogenic microbe;pathogenic virus;Pathway interactions;Pattern;Phase;phosphatidylinositol 4-phosphate;Phosphorylation;Phosphotransferases;Physiological;Post-Translational Protein Processing;Process;Production;Protein Dephosphorylation;protein kinase D;Proteins;Receptor Signaling;recruit;Regulation;Research;response;Role;Signal Induction;Signal Pathway;Signal Transduction;Silicon Dioxide;Site;Stimulus;stress granule;symporter;therapeutic development;Tissues;Toll-Like Receptor Pathway;Toll-like receptors;trans-Golgi Network;Ubiquitination;Urate;Virus Diseases

PROJECT_TITLE: Caspase-1 Activation by the Inflammasomes

STUDY_SECTION: CSRS

STUDY_SECTION_NAME: Cellular Signaling and Regulatory Systems Study Section[CSRS]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Brain Disorders;Dementia;Genetics;Huntington's Disease;Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: CAMBRIDGE

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

PHR: Project Narrative Age-related neurodegenerative diseases such as Huntington’s disease are devastating disorders for which there are no cures or effective therapeutics. A better understanding of the drivers of these diseases’ underlying pathological mechanisms will lead to better therapeutic targets. The overall long-term goal of this project is to perform cell type-specific transcriptional studies of Huntington’s disease-relevant cell types to identify and then causally test driver genes and pathways.

PI_NAMEs: HEIMAN, MYRIAM  (contact)

PROGRAM_OFFICER_NAME: MILLER, DANIEL L

PROJECT_TERMS: Address;Affinity Chromatography;age related neurodegeneration;Alzheimer's Disease;Animals;Brain;cell type;Cells;Cellular biology;Cessation of life;Clinical;Disease;disease model;disease phenotype;Functional disorder;Genes;Genetic;Genetic Transcription;Genome;Goals;Huntington Disease;immune activation;in vivo;innovation;insight;Methodology;Molecular;Neurodegenerative Disorders;Neurons;new therapeutic target;novel strategies;Parkinson Disease;Pathologic;Pathway interactions;Patients;Research;Ribosomes;RNA;screening;single cell sequencing;Testing;therapeutic target;therapeutically effective;Tissue Model;Tissues;Translating;Work

PROJECT_TITLE: Molecular Mechanisms Underlying Cell Type-Specific Vulnerability in Huntington’s Disease


ORG_CITY: TROY

ORG_NAME: RENSSELAER POLYTECHNIC INSTITUTE

PHR: Relevance This project seeks to identify and biophysically characterize transient, dynamic structures of a class of proteins called Arf GTPases, implicated in human neurological disorders and infectious disease. Therapeutic strategies to modulate Arf function requires targeting these transient structures because they correspond to the functionally relevant ones. Once validated on the Arf class of GTPases, our approach will be applicable to other GTPases implicated in cancer, Parkinson’s, Alzheimer’s and autoimmune diseases.

PI_NAMEs: ROYER, CATHERINE A (contact)

PROGRAM_OFFICER_NAME: CHO, THOMAS Y

PROJECT_TERMS: ADP-Ribosylation Factors;Alzheimer's Disease;Autoimmune Diseases;Bacteria;Binding;biophysical properties;biophysical tools;Biophysics;Brefeldin A;Cell membrane;Cell Physiology;Cell Shape;Cells;Cerebral cortex;Chemicals;Communicable Diseases;Cytokinesis;Data;Development;Disease;Endosomes;Enzymes;Eukaryotic Cell;Exclusion;Exhibits;Fluorescence;Free Energy;Genetic;Goals;Golgi Apparatus;Grain;GTP Binding;GTPase-Activating Proteins;Guanine Nucleotide Exchange Factors;Guanosine Triphosphate;Guanosine Triphosphate Phosphohydrolases;Hepatitis C virus;Human;Infection;Invaded;Investigation;Link;lipid transport;Lipids;malformation;Malignant Neoplasms;Maps;Membrane;Mental Retardation;Mitochondria;Modeling;Modification;Molecular;Molecular Conformation;molecular dynamics;molecular recognition;Monomeric GTP-Binding Proteins;Multidimensional NMR Techniques;Mutation;Mutation Analysis;myristoylation;N-terminal;Nervous System Disorder;novel;Nucleotides;Organelles;Parkinson Disease;pathogenic bacteria;pathogenic virus;Pathway interactions;Pharmaceutical Preparations;Population;Positioning Attribute;pressure;Protein Conformation;protein structure;Proteins;Regulation of Cell Size;Salmonella;Signal Pathway;Signal Transduction;Site;Solvents;Specificity;Structure;System;Therapeutic;three dimensional structure;tool;trafficking;vesicle transport;Virus;Yeasts

PROJECT_TITLE: Arf Functional Landscapes

STUDY_SECTION: MSFB

STUDY_SECTION_NAME: Macromolecular Structure and Function B Study Section[MSFB]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Neurosciences;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_DEPT: SURGERY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE Severe burn victims and patients suffering from congenital sweat gland deficiencies are unable to properly maintain body temperature, which can lead to consequences such as hyperthermia, heat stroke, brain damage, and potentially death. Uncovering the molecular mechanisms of neuronal control in sweat gland development will enhance our understanding to regenerate fully functional sweat glands with proper innervation for these patients to restore their sweating ability.

PI_NAMEs: REMARK, JULIANA THERESA (contact)

PROGRAM_OFFICER_NAME: KOSTER, MARANKE IRENE

PROJECT_TERMS: Ablation;Acetylcholine;Affect;Aftercare;beta-2 Adrenergic Receptors;Binding;Body Temperature;Brain Injuries;Burn injury;Calcium;Calcium Signaling;Cell Maintenance;cell type;Cells;Cessation of life;Chemicals;cholinergic;Data;Defect;Denervation;Dermis;Designer Drugs;Development;Down-Regulation;Duct (organ) structure;Eccrine Glands;Equilibrium;experimental study;Gene Expression;Genetic Transcription;Gland;gland development;Heat Stroke;Homeostasis;Human;Hyperthermia;Image;insight;Knock-in Mouse;Knock-out;Knockout Mice;Maintenance;Mediating;Modeling;Molecular;Morphogenesis;Morphology;Multipotent Stem Cells;Mus;Muscarinic Acetylcholine Receptor M3;Natural regeneration;Nature;Nerve;nerve supply;Neurons;Neurotoxins;neurotransmission;Neurotransmitter Receptor;Neurotransmitters;noradrenergic;Norepinephrine;Organ failure;Oxidopamine;Pathway interactions;Patients;Phenotype;Physiologic Thermoregulation;progenitor;Proliferating;Pump;receptor;receptor expression;regenerative therapy;Role;sarcolipin;Sarcoplasmic Reticulum;severe burns;Signal Transduction;single-cell RNA sequencing;Skin;Skin Tissue;Stains;stem cell differentiation;stem cells;Sweat Glands;Sweat test;Sweating;System;Three-Dimensional Imaging;transcriptome;transcriptome sequencing;Water;Work

PROJECT_TITLE: Understanding the Molecular Mechanisms of Neuronal Control in Sweat Gland Development


ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Narrative Xenotransplantation has the potential to solve the organ donor shortage and provide life-saving transplants to the ~100,000 Americans currently on the transplant wait list. However, overcoming formidable immunologic barriers is necessary before this becomes a clinical reality. This application proposes to use cutting edge genome engineering technology along with novel immunotherapeutics to overcome these barriers and bring xenotransplantation to the clinic.

PI_NAMEs: ADAMS, ANDREW B (contact);TECTOR, A JOSEPH

PROGRAM_OFFICER_NAME: NABAVI, NASRIN N

PROJECT_TERMS: Address;American;Animals;antagonist;Anti-CD40;Antibodies;Antibody Therapy;Antibody titer measurement;antibody-mediated rejection;Binding;Carbohydrates;CD4 Positive T Lymphocytes;Cell surface;Clinic;Clinical;clinical application;clinical translation;Clinical Trials;clinically relevant;Complement;Data;desensitization;Development;Enzymes;Failure;Family suidae;FDA approved;Future;Gene Deletion;Genetic Engineering;genome editing;Genome engineering;Heterophile Antigens;Human;Immune;Immune response;Immunity;Immunoglobulin G;Immunologics;Immunosuppression;Immunosuppressive Agents;Immunotherapeutic agent;improved;Individual;Injury;innovation;Kidney;Kidney Transplantation;kidney xenograft;Knock-out;Life;Long-Term Survivors;Mediating;Mutation;nonhuman primate;novel;Organ;Organ Donor;Pathway interactions;Patients;Polysaccharides;Population;Positioning Attribute;Pre-Clinical Model;prevent;Prevention;Primates;Proteasome Inhibition;Proteins;Protocols documentation;Reagent;Reporting;Role;Source;species difference;success;Techniques;Technology;Testing;Tissue Donors;Tissues;TNFRSF5 gene;TNFSF5 gene;Transferase;transplant model;Transplantation;Wait Time;Waiting Lists;Work;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Strategies to Optimize Pig-to Primate Kidney Xenograft Survival


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Physical Activity;Physical Rehabilitation;Prevention;Rehabilitation;Telehealth;Women's Health Research

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: RELEVANCE Older women with gynecologic cancer receiving chemotherapy experience treatment toxicity, increased frailty, and impaired quality of life. Physical activity may mitigate these effects. The findings of this study will result in a scalable and efficient physical activity intervention (Fit4Treatment) specifically designed for these survivors to ultimately improve their health, quality of life and survival.

PI_NAMEs: BARBER, EMMA  (contact)

PROGRAM_OFFICER_NAME: RADZISZEWSKA, BARBARA

PROJECT_TERMS: Accelerometer;Address;Adherence;Adjuvant Chemotherapy;Age;age acceleration;age effect;Aging;aging related disease;Anxiety;Cancer Patient;cancer survival;Cancer Survivor;cancer therapy;cancer type;cardiorespiratory fitness;Caring;cervical and uterine cancer;chemotherapy;Clinical Trials;Clinical Trials Design;design;Disseminated Malignant Neoplasm;Dose;evidence base;Exercise;exercise intervention;experience;Fatigue;follow-up;frailty;functional decline;functional outcomes;Goals;Health;Health Benefit;Health Care Visit;health related quality of life;Health system;Health Technology;high risk population;Histology;Impairment;improved;Individual;Inferior;innovation;Intervention;Knowledge;Malignant Female Reproductive System Neoplasm;Malignant Neoplasms;Measures;Mediator;mHealth;mortality;multi-component intervention;multiphase optimization strategy;older adult;older patient;older women;Oncology;Outcome;Ovarian;Participant;Patient Outcomes Assessments;Patients;Performance;Persons;Physical activity;Physical Function;Population;Population Heterogeneity;Progression-Free Survivals;Provider;Quality of life;Randomized;randomized trial;Recommendation;remote delivery;Research;Research Design;sarcopenia;sedentary;Self Efficacy;Social support;Strenuous Exercise;success;Survivors;Symptom Burden;Symptoms;Testing;Time;Toxic effect;Toxicity due to chemotherapy;Treatment-related toxicity;United States;wearable device;Woman;Work

PROJECT_TITLE: PATIENT-TAILORED PHYSICAL ACTIVITY INTERVENTION AMONG OLDER WOMEN WITH GYNECOLOGIC CANCERS UNDERGOING CHEMOTHERAPY (FIT4TREATMENT)

STUDY_SECTION: BMHO

STUDY_SECTION_NAME: Biobehavioral Medicine and Health Outcomes Study Section[BMHO]


NIH_SPENDING_CATS: HIV/AIDS;Infectious Diseases;Women's Health Research

ORG_CITY: LONDON

ORG_COUNTRY: CANADA

ORG_FIPS: CA

ORG_NAME: UNIVERSITY OF WESTERN ONTARIO

ORG_STATE: ON

ORG_ZIPCODE: N6A 3K7

PHR: Rapid evolution of HIV within an infected individual leads to immune escape and has been hallmark feature of this slow progressing disease. Although each new infection in women is typically established by a single HIV clone, we recently discovered that the female genital tract is infected by diverse HIV-1 population and that the severe genetic bottleneck at transmission may occur from the vaginal tract to the blood. In this grant proposal, we will define the specific sugars on the HIV-1 coat that can break the sugar-binding vaginal trap and lead to systemic infection in the hopes of defining a specific viral attribute to target with various prevention strategies.

PI_NAMEs: ARTS, ERIC J (contact)

PROGRAM_OFFICER_NAME: REFSLAND, ERIC WILLIAM

PROJECT_TERMS: Acute;Acute Disease;Address;Adopted;Affinity;analysis pipeline;Applications Grants;Binding;Bioinformatics;Blood;C-Type Lectins;CD4 Lymphocyte Count;CD4 Positive T Lymphocytes;Cell Line;Cells;Cervical;Characteristics;chemokine;Chronic;Chronic Disease;Coculture Techniques;college;Communicable Diseases;Coupled;cytokine;Data;Dendritic Cells;design;Development;Disease;Disease Progression;Effectiveness;Evolution;experimental study;Exposure to;Female;Female genitalia;female reproductive tract;fitness;Funding;Genetic;Genetic Variation;Glycoproteins;glycosylation;Grant;Heterosexuals;HIV;HIV envelope protein;HIV Envelope Protein gp120;HIV-1;HIV-1 vaccine;Human;Immune;Immune response;improved;in vivo evaluation;Individual;Infection;Integration Host Factors;Lectin;Link;Macrophage;male;Male Genital Organs;Measures;Methods;Microbe;microbiome;Modeling;Mucous Membrane;Nature;Paper;Pathogenesis;Pathogenicity;Patients;Pattern;penis;penis foreskin;Plasma;Polysaccharides;Population;Population Heterogeneity;Prevention strategy;Property;Publications;Publishing;Rectum;reproductive tract;Research;Sampling;Sexual Transmission;Site;Specialist;sugar;System;Systemic infection;T-Lymphocyte;Techniques;Testing;Th1 Cells;Tissues;transmission process;Treatment Failure;Vagina;Variant;Viral;Viral Load result;Virus;Woman;Work

PROJECT_TITLE: Determinants of HIV transmission fitness


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Drug Abuse (NIDA only);HIV/AIDS;Health Services;Infectious Diseases;Methamphetamine;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: LA JOLLA

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE Substantial resources have been invested to combat the HIV epidemic; however, methamphetamine use is a persistent and growing concern in the U.S. that contributes to worse patient outcomes and HIV transmission. An integrated treatment that addresses methamphetamine use and adherence to HIV treatment may help advance efforts to end the HIV epidemic. Building from a large body of evidence showing the effectiveness of a behavioral treatment (called contingency management) for treating methamphetamine use disorder, we plan to identify resources required to implement contingency management programs in settings serving people with HIV, as well as to adapt and evaluate a contingency management program that dually targets reductions in methamphetamine use and increased adherence to HIV treatment.

PI_NAMEs: MONTOYA, JESSICA LYNETTE (contact)

PROGRAM_OFFICER_NAME: WEBB, CANDACE KARONDELETTE

PROJECT_TERMS: Abstinence;addiction;Address;Adherence;antiretroviral therapy;Area;Behavior Therapy;Biological;career;career development;Caring;Clinical Trials;combat;comorbidity;contingency management;Continuity of Patient Care;design;Development;Development Plans;effective intervention;Effectiveness;effectiveness evaluation;Epidemic;Evaluation;evidence base;Evidence based practice;Evidence based treatment;experience;Five-Year Plans;Goals;health goals;Health Services;HIV;implementation framework;implementation science;improved;improved outcome;incentive-based intervention;Incentives;Individual;Intervention;Investments;Knowledge;Link;Mentored Patient-Oriented Research Career Development Award;Mentors;methamphetamine effect;methamphetamine use;Methamphetamine use disorder;Methodology;Methods;Modeling;National Institute of Drug Abuse;NIH Office of AIDS Research;novel;Operant Conditioning;patient engagement;Patient-Focused Outcomes;Persons;Positioning Attribute;Positive Reinforcements;Predisposition;Prize;Process;programs;Provider;psychosocial;Public Health;Randomized;Recommendation;Regimen;Reporting;Research;Research Activity;Research Personnel;Research Priority;Research Project Grants;Resources;Science;skills;stimulant use;Strategic Planning;substance use;Substance Use Disorder;success;System;Targeted Research;Testing;therapy adherence;Toxicology;Training;Training Activity;Training Programs;transmission process;Urine

PROJECT_TITLE: An integrated incentive-based treatment to optimize HIV treatment engagement among persons who use methamphetamine

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Social Determinants of Health

PHR: PROJECT NARRATIVE Health disparities in the United States are large, are historically rooted, and begin early in life. The Health Disparities Research Scholars program will train postdoctoral scholars to become interdisciplinary researchers who will advance knowledge of the causes of health disparities and of effective strategies to improve public health and health equity.

PI_NAMEs: DURKIN, MAUREEN S (contact)

PROGRAM_OFFICER_NAME: CAPPS, RANDOLPH CHRISTOPHER

PROJECT_TERMS: Health Disparities Research;Training Programs

PROJECT_TITLE: Health Disparities Research Scholars Training Program-Renewal


NIH_SPENDING_CATS: Clinical Research;Contraception/Reproduction;Genetics;Human Genome;Infertility;Pediatric;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: BOSTON

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: Project Narrative How the germ lineage arises during embryonic development and ultimately generates mature gametes is one of the least understood questions in biology and important for our understanding of developmental defects as well as genetic and epigenetic disorders. Our goal is to define the epigenetic mechanism underlying induction of developmental competence for the germ cell fate and the specification of primordial germ cells during cynomolgus gastrulation to ultimately study the genetic and epigenetic factors affecting human germ line function and their relationship with human disease. Thus, the proposed research is relevant to the NIH’s mission that pertains to ‘developing fundamental knowledge that will reduce the burden of birth defects and infertility’ and fits several of NICHD’s high priority research areas. ! !

PI_NAMEs: NEUHAUSSER, WERNER  (contact)

PROGRAM_OFFICER_NAME: TAYMANS, SUSAN

PROJECT_TERMS: Affect;amnion;Animal Model;Area;Award;Binding;Bioinformatics;Biological Assay;Biology;bisulfite;Candidate Disease Gene;candidate identification;catalyst;Cells;Cellular biology;ChIP-seq;Clustered Regularly Interspaced Short Palindromic Repeats;Competence;Computer Analysis;Congenital Abnormality;Data Set;deactivated CRISPR-Cas9;Defect;Development;Diabetes Mellitus;differentiation protocol;Disease;DNA Methylation;Drug Addiction;Embryo;Embryonic and Fetal Development;Embryonic Development;Epiblast;Epigenetic Process;epigenome;epigenome editing;epigenomics;Evolution;experience;experimental study;Future;Gametogenesis;gastrulation;gene network;gene regulatory network;Genes;Genetic;Genetic study;Genetic Transcription;genomic data;Genomics;Germ;Germ Cells;Germ Layers;Germ Lines;Goals;Grant Review;histone modification;Human;human disease;human embryonic development;human pluripotent stem cell;improved;In Vitro;in vivo;Infertility;Institution;instructor;interest;Investigation;Israel;Knowledge;laboratory experience;Late-Onset Disorder;Link;loss of function;Macaca fascicularis;Maintenance;Malignant - descriptor;Malignant Neoplasms;Maps;Measures;Mediating;Medical center;Meiosis;Mentors;Mesoderm;Mission;Modeling;morphogens;multidisciplinary;Mus;National Institute of Child Health and Human Development;nonhuman primate;offspring;Outcome;Phenotype;Physicians;pluripotency;pluripotent stem cell differentiation;Pluripotent Stem Cells;Pregnancy loss;programs;promoter;Protocols documentation;Regulator Genes;Regulatory Element;Reporter;Repression;Reproductive Endocrinology;reproductive outcome;Research;Research Personnel;Research Priority;Rest;Role;Somatic Cell;Specific qualifier value;stem cell biology;stem cells;Structure of primordial sex cell;Testing;timeline;tool;Totipotent;Training;transcription factor;Transcriptional Activation;transdifferentiation;United States National Institutes of Health;whole genome

PROJECT_TITLE: Epigenetic determinants of competence for germ line specification during human embryonic development

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Reproduction, Andrology, and Gynecology Study Section[CHHD-R]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Diabetes

PHR: Narrative: The overall goal of our research is to under how a key signaling molecule, cyclic AMP (cAMP), regulates a variety of different cellular functions in pancreatic  cells with exquisite specificity. As aberrations in the cAMP signaling pathway are implicated in clinical conditions such as obesity and type 2 diabetes mellitus, a better mechanistic understanding should help identify sites of dysfunction and potential targets for therapeutic intervention.

PI_NAMEs: ZHANG, JIN  (contact)

PROGRAM_OFFICER_NAME: SECHI, SALVATORE

PROJECT_TERMS: A kinase anchoring protein;Affect;Beta Cell;Biological Models;Biosensor;Buffers;Catalytic Domain;cell growth;Cell membrane;Cell Physiology;Cells;Clinical;CRISPR/Cas technology;Cyclic AMP;Cyclic AMP Response Element;Cyclic AMP-Dependent Protein Kinases;Cyclic AMP-Responsive DNA-Binding Protein;Development;Diabetes Mellitus;Diffusion;Functional disorder;Funding;Gene Expression;Genes;Genetic Transcription;glucagon-like peptide 1;Glucose;Goals;Hormones;insight;Insulin;insulin secretion;journal article;Liquid substance;Manuscripts;mathematical model;Measurement;Measures;Mediating;Metabolism;Methods;Modeling;Molecular;molecular assembly/self assembly;Mutation Analysis;nano;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;optogenetics;Pancreas;Peer Review;Pharmaceutical Preparations;Phase;phosphoric diester hydrolase;Phosphorylation;Physical condensation;Play;Process;Proliferating;Protein Dynamics;Protein Kinase;Proteins;Proteomics;Publishing;Regulation;Reporting;Research;response;Role;Second Messenger Systems;Signal Pathway;Signal Transduction;Signaling Molecule;Site;spatiotemporal;Specificity;stoichiometry;Structure of beta Cell of islet;System;targeted treatment;Technology;Testing;Therapeutic;Therapeutic Intervention;Therapeutic Uses;Time;tool;ultra high resolution;Visualization

PROJECT_TITLE: Mechanisms of Compartmentalized cAMP Signaling

STUDY_SECTION: SBCB

STUDY_SECTION_NAME: Synthetic and Biological Chemistry B Study Section[SBCB]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Dementia;Genetics;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: EL PASO

ORG_NAME: UNIVERSITY OF TEXAS EL PASO

ORG_STATE: TX

PHR: Project Narrative Alzheimer’s disease and other dementias are chronic and progressive diseases without cure, imposing a huge health economic burden in our society. The proposed research is directed at advancing our knowledge of dementia etiology, which would facilitate the development of new prevention and therapeutic strategies.

PI_NAMEs: HAN, KYUNG-AN  (contact)

PROGRAM_OFFICER_NAME: KOVBASNJUK, OLGA NIKOLAEVNA

PROJECT_TERMS: Acetylcholine;Address;Affect;Age;age related;age related neurodegeneration;Alleles;Alzheimer's Disease;Alzheimer's disease related dementia;American;Amyloid;Animal Model;biological research;Biomedical Research;Candidate Disease Gene;Caregivers;caucasian American;Chronic Disease;combat;Communities;conditioning;Consumption;cost;cost effective;Deletion Mutation;Dementia;Development;Disease;Dissection;DNA Sequence Alteration;dopaminergic neuron;Drosophila genus;Drosophila melanogaster;Economic Burden;Elderly;endophenotype;Enzymes;Etiology;executive function;fly;gene discovery;Gene Expression;gene function;Gene Mutation;Genes;Genetic;Genetic Crosses;genetic risk factor;Genetic Screening;genome wide association study;genomic locus;Goals;health economics;Hispanic Populations;human old age (65+);innovation;Insertion Mutation;insight;Intercistronic Region;Introns;Knowledge;Link;Mammals;Measures;Memory;Memory Loss;model organism;mutant;Mutation;Nerve Degeneration;neural;Neurosciences Research;non-genetic;Oxidative Stress;Pathogenicity;Point Mutation;Prevalence;Prevention;Process;Progressive Disease;Research;Research Training;Rest;Risk Factors;RNA Interference;Rodent Model;Role;screening;Sleep Deprivation;social factors;social stress;Societies;Students;Symptoms;Synapses;tau aggregation;Tauopathies;Testing;Therapeutic;Time;tool;Training and Education;transgene expression;X Chromosome

PROJECT_TITLE: Genetic dissection of dementia


ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: PROJECT NARRATIVE. Microglia are brain-resident immune cells whose role in prolonged seizures (otherwise known as status epilepticus) during development is not known. Emerging research in neurodegenerative diseases suggest that targeting microglia is a promising approach to treat such diseases. This proposal investigates the possibility of manipulating microglia, with a special focus on one of its principal receptors, in developing mice as a pre-clinical model for seizure management in pediatric seizures and epilepsy development.

PI_NAMEs: EYO, UKPONG BASSEY (contact)

PROGRAM_OFFICER_NAME: LEENDERS, MIRIAM

PROJECT_TERMS: Address;Adult;Affect;Age;antagonist;Anti-Inflammatory Agents;Astrocytes;Behavior assessment;Body Temperature;Brain;brain cell;cell type;Cells;Central Nervous System;Chemicals;Child;Childhood;Complex;Convulsions;cytokine;Data;Death Rate;Development;Disease;drug development;early life exposure;Environment;Epilepsy;experience;Exposure to;Febrile Convulsions;Fever;G-Protein-Coupled Receptors;Genes;Genetic;Histopathology;Homeostasis;Hyperactivity;Immune;Immunocompetent;Induced Hyperthermia;Inflammation;Inflammation Mediators;interest;Life;Literature;Masks;Microglia;Modeling;Molecular;mouse model;Mus;Neurodegenerative Disorders;Neuroimmune;neuroinflammation;Neuronal Dysfunction;Neurons;novel;novel strategies;Pathology;Peripheral;Pharmaceutical Preparations;pharmacologic;Phenocopy;Phenotype;Play;Pre-Clinical Model;Purines;receptor;receptor function;Recurrence;Research;Research Personnel;Risk Factors;Rodent Model;Role;Seizures;selective expression;Severities;Status Epilepticus;Temporal Lobe Epilepsy;Testing;Work;Zebrafish

PROJECT_TITLE: Targeting Microglia in Febrile Status Epilepticus

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]