NIH_SPENDING_CATS: Aging;Bioengineering;Eye Disease and Disorders of Vision;Macular Degeneration;Nanotechnology;Neurodegenerative;Neurosciences

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE In this project, we will investigate a new therapeutic and drug delivery system to treat the two key disease pathways associated with age-related macular degeneration (AMD), inflammation and oxidative stress. Anti- VEGF therapeutics are currently used to mitigate neovascularization, but this does not treat the inflammatory pathway of the disease, and the need for frequent intravitreal injections results in high costs and burdens the patients and health care system. The objective of this work is to perform in vivo validation of an injectable, biodegradable, stimuli-responsive nanoparticle delivery system that can sustain release of an investigational therapeutic to treat retinal inflammation for several months.

PI_NAMEs: SWINDLE-REILLY, KATELYN E (contact)

PROJECT_TERMS: adverse event risk;Affect;age related;Age related macular degeneration;Albumins;Animal Model;Anti-Inflammatory Agents;Apoptosis;barrier to care;Binding;Biodegradation;biomaterial compatibility;Blindness;Blood Vessels;Cells;Clinical;clinical examination;combinatorial;cost;Data;Disease;disease model;Disease Pathway;Disease Progression;Dose;Drug Delivery Systems;efficacy study;Enzyme-Linked Immunosorbent Assay;Evaluation;experience;Eye;Eye diseases;Flow Cytometry;Frequencies;fundus imaging;Future;Goals;Growth;Health;Healthcare Systems;Heme;heme oxygenase-1;High Pressure Liquid Chromatography;Histology;Human;Immunohistochemistry;improved;In Vitro;in vivo;in vivo Model;Inflammation;Inflammatory;inflammatory marker;Injectable;Injections;intravitreal injection;life span;Measures;Microglia;Modeling;mouse model;Mus;nanoparticle;nanoparticle delivery;neovascularization;Neurodegenerative Disorders;Nonexudative age-related macular degeneration;novel;novel therapeutic intervention;novel therapeutics;Optical Coherence Tomography;Outcome;overexpression;Oxidative Stress;Pain;Patients;Persons;Pharmaceutical Preparations;Physiologic Intraocular Pressure;Physiology;pre-clinical;Pre-Clinical Model;prevent;Quality of life;Reactive Oxygen Species;Research;Research Personnel;Retina;retinal damage;Risk;Safety;Serum Albumin;sodium iodate;Stains;standard care;Stimulus;Structure of retinal pigment epithelium;success;System;Testing;Therapeutic;Tissues;Translations;Treatment Cost;Treatment Efficacy;uptake;Validation;Vascular Endothelial Growth Factors;Vision;Work

PROJECT_TITLE: Evaluation of New Anti-inflammatory Treatments for Age-Related Macular Degeneration

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-NV-P(81)S]


ADMINISTERING_IC: EY

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: BALTIMORE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative Identifying and using an object depends on knowing its shape, which we perceive through both our senses of touch and vision. How the brain combines haptic and visual shape information remains unknown. By understanding the neural mechanisms underlying visuo-haptic shape representations, this project will support the generation of neuroprosthetic implants.

PI_NAMEs: SNIDER, WILLIAM GRAYSON (contact)

PROGRAM_OFFICER_NAME: CLAYTON, EDWIN C

PROJECT_TERMS: 3-Dimensional;3D Print;Address;Anatomy;Area;arm;Auditory;Awareness;Bilateral;Brain;Cells;Code;Complex;Cues;Development;Electrophysiology (science);Environment;experience;Exposure to;Face;Functional Magnetic Resonance Imaging;Generations;grasp;Hand;haptics;Homologous Gene;Human;Image;Implant;Individual;inferotemporal cortex;Knowledge;Lateral;Lesion;Location;Macaca;Memory;Modality;neural;neuromechanism;Neurons;neuroprosthesis;next generation;novel;object recognition;object shape;Pathway interactions;Perception;Positioning Attribute;Process;recruit;Research;Resolution;Robotics;Role;Sensory;sensory input;Shapes;Stimulus;Tactile;Testing;Touch sensation;ventral visual stream;Vision;Visual;Visual Agnosias;visual information;visual processing

PROJECT_TITLE: Modality-independent representations of object shape in macaque inferotemporal cortex


ADMINISTERING_IC: OD

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Data Science;Dental, Oral, and Craniofacial Disease;Genetics;Heart Disease;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: SAN FRANCISCO

ORG_NAME: J. DAVID GLADSTONE INSTITUTES

ORG_STATE: CA

PHR: PROJECT NARRATIVE Mapping the network of genes disrupted in human disease allows us to design treatments that correct the network back to the normal state to treat the core disease process rather than only managing symptoms. However, mapping the network requires large amounts of data to learn the connections between genes, and in many human diseases we do not have enough data to confidently map the network, especially in rare diseases and diseases that affect tissues in the body that are difficult to reach to obtain samples to study, like the heart. In this research, we develop a new method for computers to learn connections between genes from tissues where we do have a large amount of data, serving as a knowledge base so that the machine can then confidently map the networks disrupted even in diseases where we have only a small amount of data, enabling us to design network-correcting treatments for those diseases.

PI_NAMEs: THEODORIS, CHRISTINA VICKY (contact)

PROGRAM_OFFICER_NAME: MILLER, BECKY

PROJECT_TERMS: Acceleration;Address;Affect;Automobile Driving;Back;base;Biology;candidate identification;Cardiac;Cardiac Myocytes;Cardiovascular Diseases;Cardiovascular system;cell type;Cells;Chromosome Mapping;Clinical;Clinical Trials;collaborative environment;Computational Biology;Computer Vision Systems;Computing Methodologies;computing resources;Copy Number Polymorphism;Data;Data Set;deep learning model;Dependence;design;Disease;Disease Progression;dosage;drug discovery;experience;experimental study;Financial Support;Fostering;Gene Combinations;Gene Dosage;gene network;gene regulatory network;Genes;Genetic;genetic disorder diagnosis;genetic variant;Growth;Heart;Heart Diseases;Heart Valve Diseases;Human;human disease;human induced pluripotent stem cells;human tissue;Hypertrophic Cardiomyopathy;improved;in silico;Individual;induced pluripotent stem cell;Institution;Interdisciplinary Study;knowledge base;Laboratories;Leadership;Learning;Life;Machine Learning;machine learning model;Maps;Medical;medical schools;Mentors;Mentorship;Modeling;Natural Language Processing;Network-based;novel;Patients;Phenotype;Physicians;Positioning Attribute;pre-trained model;Process;programs;Progressive Disease;Rare Diseases;Reporting;Research;Role;Sampling;Science;Scientist;screening;stem cell model;success;symptom management;targeted treatment;Technology;Testing;Therapeutic;therapy design;Tissues;Training;transcriptome;transcriptomics;transfer learning;Uncertainty;Validation

PROJECT_TITLE: Transfer learning leveraging large-scale transcriptomics to map disrupted gene networks in cardiovascular disease


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: MEMPHIS

ORG_NAME: UNIVERSITY OF MEMPHIS

ORG_STATE: TN

PHR: It has been increasingly recognized that asthma is a consequence of joint activities among genes rather than of individual genes’ independent contributions. We propose an approach to detect distinct epigenetic networks (DENs) with each unique to a group of subjects via network clustering using DNA methylation (DNAm) data before disease manifestation, e.g., at-birth DNAm and childhood asthma. Next, we will study the longitudinal association of DENs at birth with asthma incidence in children, post-adolescence, and young adulthood, assess the role of age, sex, and race in this association, and examine the benefit of evaluating joint rather than individual activities of CpGs on asthma incidence.

PI_NAMEs: ZHANG, HONGMEI  (contact)

PROGRAM_OFFICER_NAME: MINNICOZZI, MICHAEL

PROJECT_TERMS: Address;Adolescence;Age;age related;Agreement;Asthma;base;Birth;Child;Childhood;Childhood Asthma;cohort;Cytosine;Data;Detection;Development;Disease;DNA Methylation;Epidemiology;epidemiology study;Epigenetic Process;Etiology;Evaluation;follow-up;Future;gene network;General Population;Genes;genetic variant;genome-wide;Guanine;Health;Heterogeneity;high risk;improved;Incidence;Individual;inorganic phosphate;Joints;Knowledge;Label;late life;Life;Longitudinal cohort;Longitudinal Studies;Machine Learning;Malignant Neoplasms;Manuals;Mendelian randomization;Meta-Analysis;Methods;Methylation;microbiome research;multi-racial;novel strategies;Obesity;Parents;Participant;Pathogenesis;Patients;Population;Pregnancy;prevent;Prevention;Proteomics;Quantitative Trait Loci;Race;Recording of previous events;Risk;Role;screening;Selection Bias;sex;simulation;Single Nucleotide Polymorphism;Site;Specificity;Statistical Methods;Techniques;Testing;Time;transcriptomics;Uncertainty;Validation;web-based tool;Work;young adult

PROJECT_TITLE: Clusters of Epigenetic Networks at Birth and Asthma Incidence in Children

STUDY_SECTION: CRD

STUDY_SECTION_NAME: Cardiovascular and Respiratory Diseases Study Section[CRD]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Cancer Genomics;Clinical Research;Dental, Oral, and Craniofacial Disease;Genetics;Human Genome;Immunotherapy;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Precision Medicine;Women's Health Research

ORG_CITY: GAINESVILLE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE Anti-PD-1 chemoimmunotherapeutic treatment strategies rely on chemotherapy-induced immunomodulation (chemo-immunomodulation) for efficacy against metastatic triple-negative breast cancer and have hitherto performed unsatisfactorily. The goal of this project is to identify, characterize, and establish the clinical relevance of genomic and transcriptomic features that influence chemo-immunomodulation in metastatic triple-negative breast cancer and utilize the data generated from the studies herein to develop a machine-learning-based model predictive of chemo-immunomodulation by select agents. The results of this study may provide critical insights that inform novel paradigms for designing, optimizing, and maximizing the efficacy of anti-PD-1 chemoimmunotherapeutic strategies in metastatic triple-negative breast cancer based on patient-specific genomic and transcriptomic features and their effect on chemo-immunomodulation.

PI_NAMEs: GBADAMOSI, MOHAMMED OLUSOJI (contact)

PROJECT_TERMS: 3-Dimensional;Acute Myelocytic Leukemia;African American;anti-PD-1;Antibodies;Area;Award;Basic Science;Big Data;Biological;Breast Cancer cell line;Breast Cancer Model;Breast Cancer Patient;Breast Cancer Treatment;Cancer Center;cancer subtypes;career;career development;Cell Culture System;Characteristics;Chemoresistance;chemotherapeutic agent;chemotherapy;Clinical;Clinical Sciences;clinically relevant;Collaborations;Communities;comparative;CRISPR screen;Data;Data Analyses;Department chair;design;Development;Discipline;Disparity;Drug Industry;Educational Status;Ensure;Ethnic Origin;experience;Faculty;Feedback;Fellowship;flexibility;Florida;Foundations;Funding;Gene Expression;genome-wide;genomic variation;Genomics;Goals;Head;Health;Heterogeneity;Hispanic;Human;Human Resources;Immuno-Chemotherapy;immunoregulation;Immunotherapeutic agent;improved;In Vitro;in vivo;individual patient;insight;Institution;Leadership;Legal patent;Machine Learning;machine learning model;machine learning prediction;Malignant Breast Neoplasm;Malignant Neoplasms;Manuscripts;medically underserved;meetings;Mentors;Mentorship;Minor;Modeling;Molecular;mouse model;multidisciplinary;Mus;Neoplasm Metastasis;next generation;novel;novel strategies;Outcome;Patients;PD-1 blockade;Pharmacotherapy;Play;Positioning Attribute;pre-clinical;professor;programs;Progression-Free Survivals;Publications;Research;Research Personnel;Residencies;Resources;response;Role;single-cell RNA sequencing;skill acquisition;skills;Solid Neoplasm;Specimen;Students;synergism;targeted treatment;Techniques;tenure track;Therapeutic;Therapeutic Intervention;Therapeutic Uses;Time;Training;transcriptomics;Translational Research;Treatment Efficacy;treatment response;treatment strategy;triple-negative invasive breast carcinoma;tumor;tumor microenvironment;United States National Institutes of Health;Universities;Variant;Work

PROJECT_TITLE: Decoding the Heterogeneity in Chemo-Immunomodulation to Unlock the Potential of Chemoimmunotherapy in Metastatic Triple-Negative Breast Cancer


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics

ORG_CITY: Chicago

ORG_DEPT: PHYSICS

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: Biomolecules can self-organize into membraneless condensates by phase separation. We will investigate how chromatin features determine where transcription condensates form in the cell nucleus, and how condensates structure transcription activity. This knowledge is important to understand how biological functions arises from chromatin-condensate structures in health and disease.

PI_NAMEs: SPILLE, JAN-HENDRIK  (contact)

PROGRAM_OFFICER_NAME: CHOW, CHI-WING

PROJECT_TERMS: Binding Sites;Biological Process;biophysical model;Cell Nucleus;Cell Physiology;Cells;Chromatin;Chromatin Structure;Data;Development;Disease;Elements;Enhancers;Epigenetic Process;Genetic Transcription;genome-wide analysis;Genomics;Health;Informal Social Control;Knowledge;Link;Membrane;Microscopy;Modeling;Modification;Molecular;Mouse Embryonic Stem Cells;Nature;Nuclear;Organelles;Phase;Physical condensation;programs;Proteins;Regulatory Element;Research;Resolution;scaffold;self organization;Structure;superresolution microscopy;Surface;Testing;Time;transcription factor;Transcriptional Regulation;Vision

PROJECT_TITLE: Structural and functional determinants of biomolecular condensates in transcription organization

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


NIH_SPENDING_CATS: Biotechnology;Dental, Oral, and Craniofacial Disease;Immunotherapy

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE B cell signaling is central to the adaptive immune response, serving as the basis for generation of humoral immunity to foreign agents. A multi-component co-receptor complex carefully regulates the strength of B cell signaling, and dysregulation of signaling through this complex can lead to autoimmunity, immunodeficiency, and B cell cancers. This research program will elucidate the molecular details of how the B cell co-receptor complex functions, is regulated by novel accessory components, and will engineer new tools to modulate B cell function, laying the foundation for new immunomodulatory therapeutics.

PI_NAMEs: SUSA, KATHERINE JULIA (contact)

PROJECT_TERMS: adaptive immune response;Antibodies;antigen binding;Antigens;Attenuated;Autoimmune Diseases;Autoimmunity;autoreactive B cell;Award;B Cell Proliferation;B cell therapy;B lymphoid malignancy;B-Cell Activation;B-Cell Antigen Receptor;B-Lymphocytes;Biochemical;Biological Assay;cancer cell;CD19 gene;CD81 gene;Cell membrane;Cell Physiology;Cell surface;Cells;Cellular biology;Collaborations;Communities;Complement 3d Receptors;Complement Receptor;Complex;Core Facility;Coupled;Creativeness;Data Collection;Dedications;design;Disease;Dissociation;Doctor of Philosophy;Engineering;Event;experience;Faculty;Fostering;Foundations;Functional disorder;Generations;Glutamate Transporter;Homeostasis;Humoral Immunities;Hyperactivity;immune modulating agents;Immune response;Immunity;immunodeficiency;Immunologist;Immunology;Immunosuppression;Immunotherapy;improved;Individual;innovation;Institution;Investigation;Label;Lead;Learning;Ligand Binding;Link;Malignant - descriptor;Mass Spectrum Analysis;member;Mentors;Mentorship;Molecular;neutralizing antibody;new therapeutic target;novel;Paper;Pathogenicity;Pathologic;Pharmaceutical Chemistry;Positioning Attribute;preservation;prevent;programs;Protein Engineering;Proteins;Publishing;receptor;Receptor Signaling;recruit;Regulation;Reporting;Research;response;Rest;Role;senior faculty;SHPS-1 protein;side effect;Signal Pathway;Signal Transduction;Signaling Protein;structural biology;Structure;targeted treatment;Technical Expertise;Techniques;Technology;tenure track;Therapeutic;tool;Toxic effect;Training;transmission process;Work

PROJECT_TITLE: Identifying, Characterizing, and Targeting Regulators of B Cell Activation


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Breast Cancer;Cancer;Clinical Research;Data Science;Health Services;Lung;Lung Cancer;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Precision Medicine;Prevention;Women's Health Research

ORG_CITY: TAMPA

ORG_NAME: H. LEE MOFFITT CANCER CTR & RES INST

PHR: PROJECT NARRATIVE Cancer screening modalities are often associated with false positives, high rates of indeterminate findings, overdiagnosis, and overtreatment, which are all serious limitations that can be addressed with imaging. Our group pioneered image biomarker approaches leveraged in the prior funding cycle to create the first and only EDRN Clinical Validation Center (CVC) to dedicated to the validation of image biomarkers to improve early detection of cancer. In this renewal application, we build on our initial progress to bring practical automated solutions to these pressing screening problems.

PI_NAMEs: HEINE, JOHN J (contact);SCHABATH, MATTHEW B.

PROGRAM_OFFICER_NAME: MAZURCHUK, RICHARD V

PROJECT_TERMS: Address;Algorithms;Artificial Intelligence;Artificial Intelligence platform;Benchmarking;Benign;bioimaging;Biological Markers;Biopsy;Biostatistical Methods;Blood;Breast;breast density;breast imaging;cancer biomarkers;Cancer Center;Cancer Detection;cancer diagnosis;Classification;Clinical;Clinical Data;clinical imaging;Collaborations;Colon;Communication;Complement;Comprehensive Cancer Center;Cutaneous;Data;data repository;Dedications;deep learning;Development;Diagnosis;Diagnostic;diagnostic biomarker;Discrimination;Disease;Early Detection Research Network;Early Diagnosis;Electronic Medical Records and Genomics Network;Environment;experience;Funding;Goals;Guidelines;Housing;Image;image archival system;imaging biomarker;improved;Individual;Indolent;Institution;interest;Lung;lung cancer screening;lung imaging;Machine Learning;Malignant - descriptor;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant Neoplasms;Mammography;Measurement;Medical Imaging;Modality;Modeling;Mutation;Nodule;non-invasive imaging;novel;Operative Surgical Procedures;Organ;Ovary;overtreatment;Pancreas;patient population;Performance;personalized cancer care;Play;Population;Prediction of Response to Therapy;Process;Productivity;prognostication;Prostate;quantitative imaging;radiomics;Recurrence;repository;Research;Resected;Resources;Risk;Risk Marker;risk prediction;Role;Sampling;screening;Screening for cancer;Shapes;Site;standard of care;Subcategory;Subgroup;success;Sum;Techniques;Technology;Texture;Tissues;treatment response;tumor;Validation;Vascularization;Woman;working group

PROJECT_TITLE: Quantitative Imaging Clinical Validation Center at Moffitt Cancer Center


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_CITY: BOZEMAN

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: MONTANA STATE UNIVERSITY - BOZEMAN

ORG_STATE: MT

PHR: Project Narrative Each of our cells inactivates many of its available genes to perform a unique function. Failure to properly inactivate genes underlies developmental disorders and devastating pediatric brain and blood cancers. This project investigates how cells inactivate the correct genes at the correct time during development to understand how defective gene inactivation can cause disease.

PI_NAMEs: DELUCA, STEVEN  (contact)

PROJECT_TERMS: Binding;Biological Models;Cell Culture Techniques;Cell Differentiation process;Cells;Chemicals;Childhood Malignant Brain Tumor;ChIP-seq;Chromatin;Communities;Cultured Cells;Development;developmental disease;Disease;Drosophila genus;embryonic cell culture;Embryonic Development;Engineering;Epigenetic Process;Failure;gene correction;Gene Expression;Gene Silencing;Genes;Genetic;Genetic Transcription;Genome;Genome engineering;Genomics;Hematopoietic Neoplasms;Human;Maintenance;Malignant Neoplasms;Molecular;mutant;Nurses;Organism;Polycomb;prevent;programs;Proteins;Research;Time;tool;transcription factor

PROJECT_TITLE: Developmental control of gene silencing


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF EDUCATION

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Social Determinants of Health

ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: PROJECT NARRATIVE The Baby’s First Years study will provide rigorous evidence about the causal impacts of early childhood unconditional cash transfers on family processes and brain development, learning, and behavior among children in low-income families as they transition into school at age 6. It will also assess, at age 8, the extent to which any impacts persist 20 months after the cessation of the cash transfers. Evidence from the study will inform policy debates about the benefits for children of cash income and related supports and the consequences of proposed expansions and cuts to federal and state social assistance and tax programs.

PI_NAMEs: DUNCAN, GREG JOHN (contact);GENNETIAN, LISA A;MAGNUSON, KATHERINE ;NOBLE, KIMBERLY G

PROGRAM_OFFICER_NAME: JEKIELEK, SUSAN

PROJECT_TERMS: Academic achievement;Achievement;Affect;Age;Area;Behavior;Behavioral;Brain;Caring;Child;Child Development;Child Rearing;Cognitive;cognitive skill;comparative;Data;Development;Developmental Delay Disorders;early childhood;Economics;Education;Elements;Emotional;emotional functioning;Expenditure;experience;Family;Family Process;follow-up;Frequencies;Funding;Gifts;Hair;Hand;Health;Household;Hydrocortisone;improved;Income;Infant;Informal Social Control;Investments;Learning;Life;Low income;lower income families;Marketing;maternal stress;mathematical ability;Measures;Mental Health;metropolitan;Mothers;National Institute of Child Health and Human Development;Neurobiology;Newborn Infant;Outcome;pandemic disease;Parents;Participant;Pathway interactions;Pattern;payment;Physiology;Policies;Poverty;poverty reduction;programs;Randomized;Randomized, Controlled Trials;reading ability;recruit;Reporting;Risk;Running;Schools;skills;social;Special Education;Speed;Stress;Taxes;Testing;theories;treatment effect;Well in self;Work

PROJECT_TITLE: Household Income and Child Development in the First Years of Life

STUDY_SECTION: SSPB

STUDY_SECTION_NAME: Social Sciences and Population Studies B Study Section[SSPB]


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Eye Disease and Disorders of Vision;Infant Mortality;Lung;Neonatal Respiratory Distress;Orphan Drug;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Pulmonary Hypertension;Rare Diseases

ORG_CITY: CHICAGO

ORG_NAME: LURIE CHILDREN'S HOSPITAL OF CHICAGO

PHR: PROJECT NARRATIVE: The proposed research is very relevant to public health as it aims to establish a novel non-invasive approach to assess and monitor systemic microvascular development in premature babies responding to an unmet clinical need in neonatology. This research will apply nailfold capillaroscopy to non-invasively identify infants with vascular growth impairment, e.g. retinopathy of prematurity (ROP), necrotizing enterocolitis (NEC) and pulmonary hypertension (PHTN) complicating bronchopulmonary dysplasia (BPD) which could benefit from novel therapeutic interventions aimed at preventing microvascular complications of prematurity, thus improving patient’s outcome.

PI_NAMEs: DE PLAEN, ISABELLE G (contact)

PROGRAM_OFFICER_NAME: SHEN, GRACE L

PROJECT_TERMS: Adult;Affect;Age;angiogenesis;Antibodies;Antibody Therapy;Area;Artificial Intelligence;Birth;Birth Weight;Blindness;Blood capillaries;Blood Vessels;Bronchopulmonary Dysplasia;capillary bed;Chicago;Child;Childhood;Clinical;Connective Tissue Diseases;contrast enhanced;Control Groups;Data;density;design;Development;Diagnosis;Engineering;Extremely Low Birth Weight Infant;Eye;Fingers;Future;Gestational Age;Growth;Hypoxia;Image;Impairment;improved;improved outcome;indexing;Infant;Injections;Interdisciplinary Study;interest;International;Intervention;Lasers;Length;Life;Lung;Medical;Methods;Microcirculatory Bed;Microscopic Angioscopy;Microvascular Dysfunction;Monitor;Morbidity - disease rate;mortality;Nail plate;Necrotizing Enterocolitis;Neonatal;neonate;Neonatology;Non-Invasive Detection;novel;novel therapeutic intervention;ophthalmic examination;Ophthalmology;Organ;Pathogenicity;Patient-Focused Outcomes;Pediatric Hospitals;Play;postnatal;premature;Premature Infant;preservation;preterm newborn;Prevalence;prevent;Process;Production;Prospective cohort;Protocols documentation;Public Health;Pulmonary Hypertension;relapse prediction;Research;Resolution;Retina;retina blood vessel structure;Retinal Detachment;Retinopathy of Prematurity;ROC Curve;Role;Schools;skeletal;Software Tools;Structure;targeted treatment;Techniques;Testing;Time;tool;Universities;Vascular Endothelial Growth Factors;Vascular System;VEGFA gene;Very Low Birth Weight Infant

PROJECT_TITLE: Novel non-invasive approach for predicting retinopathy of prematurity in premature neonates

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]


ORG_CITY: BURLINGTON

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE

ORG_STATE: VT

PHR: PROJECT NARRATIVE Endolysosomal vesicles use molecular motors to move long distances on microtubules, and they influence a range of cellular functions including growth, division, and survival. Perturbations in microtubule-based transport and vesicular trafficking underlie many neurological diseases and cancer. This research aims to elucidate how vesicles attach to molecular motors and how their movement directs the distribution of other organelles via membrane contact sites.

PI_NAMEs: SALOGIANNIS, JOHN  (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TERMS: Adaptor Signaling Protein;Address;Affect;age-related disease;Binding;Biochemistry;Biological Models;cell growth;Cell Physiology;Defect;Development;Dynein ATPase;Eukaryotic Cell;Genetic;Goals;Growth;Kinesin;Link;LRRK2 gene;macromolecule;malignant neurologic neoplasms;Membrane;Microscopy;Microtubules;Molecular;Molecular Motors;Motor;Movement;Mutation;Nervous System Disorder;Neurodegenerative Disorders;Neurodevelopmental Disorder;organelle movement;Organelles;Parkinson Disease;Phosphorylation Site;Phosphotransferases;Play;Positioning Attribute;rab GTP-Binding Proteins;recruit;Research;Role;Site;Specificity;trafficking;Vesicle

PROJECT_TITLE: Increasing the Complexity of Microtubule-based transport: Cargo adaptors and Hitchhiking on Vesicles.

STUDY_SECTION: MRAD

STUDY_SECTION_NAME: Maximizing Investigators' Research Award - D Study Section[MRAD]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: PITTSBURGH

ORG_DEPT: BIOLOGY

ORG_NAME: CARNEGIE-MELLON UNIVERSITY

ORG_STATE: PA

PHR: PROJECT NARRATIVE FOR OVERALL COMPONENT Echinobase is a model organism knowledgebase for the echinoderm research community. Genomic resources and links out to other databases are provided through a design that facilitates rapid user access to information. Features have been guided by the community and developed upon FAIR principles.

PI_NAMEs: ETTENSOHN, CHARLES A.;HINMAN, VERONICA FRANCES (contact);VIZE, PETER D

PROGRAM_OFFICER_NAME: STEIN, KATHRYN K

PROJECT_TERMS: Access to Information;Address;ATAC-seq;Atlases;base;bioinformatics tool;Biological Models;Cells;Code;Communication;Communities;Computer software;Consultations;Consumption;Controlled Vocabulary;cost;Data;data integration;data management;data mining;data sharing;Databases;design;Development;Developmental Gene;Disease;DNA methylation profiling;EchinoBase;Echinodermata;Embryonic Development;empowerment;Experimental Models;FAIR principles;Fostering;Funding;Future;Gene Expression;gene regulatory network;Genes;Genetic Transcription;Genome;genome resource;genomic data;Genomics;Goals;Health;Human;improved;Infrastructure;interoperability;Investments;Knowledge;knowledgebase;Letters;Link;Logic;Mission;model organism;Names;Nomenclature;Ontology;ontology development;Organism;Pattern;Performance;Play;predictive modeling;Process;relational database;repository;Research;Research Personnel;Resources;Role;Sea Urchins;Systems Analysis;Taxonomy;Time;Tissues;tool;transcriptome sequencing;United States National Institutes of Health;Untranslated RNA;Update;usability;user-friendly;Visualization software;web app;web site;web-accessible;Work;XCL1 gene;XenBase

PROJECT_TITLE: Enhanced Echinobase: A Community Genomics Research Resource For The Future


PI_NAMEs: HINMAN, VERONICA FRANCES (contact)

PROJECT_TITLE: Administrative  Core: An Integrated Multi PI And Multi Site Management Plan For Enhanced Echinobase


NIH_SPENDING_CATS: Biotechnology;Dental, Oral, and Craniofacial Disease;Genetics;Human Genome;Neurosciences

ORG_CITY: SEATTLE

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE The precise control of gene expression is crucial for the faithful orchestration of the developmental program, but mis-expression of genes can be pathogenic in many contexts. The proposed work will combine advances in large-scale DNA synthesis and single-cell sequencing to study the regulation of genes that pattern the developing nervous system, but are also implicated in diseases such as Alzheimer’s and cancer. Therefore, the results of this project will reveal fundamental principles of development but will also inform disease mechanisms and potential therapies.

PI_NAMEs: PINGLAY, SUDARSHAN  (contact)

PROJECT_TERMS: activating transcription factor;Alzheimer's Disease;Area;Bar Codes;Binding;Binding Sites;Biochemical;Cell division;cell type;Cells;Characteristics;Chromatin;Clustered Regularly Interspaced Short Palindromic Repeats;Code;Collaborations;Communities;Core Facility;Data Set;Dedications;Development;differential expression;Disease;DNA biosynthesis;Doctor of Philosophy;Environment;epigenetic memory;Epigenetic Process;Equipment;experience;experimental study;extracellular;Faculty;Gene Expression;Gene Expression Profile;Gene Expression Regulation;Genes;Genetic Transcription;Genome;genomic locus;Genomic Segment;Genomics;Glean;Grant;Individual;Inherited;Institution;Laboratories;large datasets;Lead;Location;Logic;Maintenance;Malignant Neoplasms;meetings;member;Mentors;Modeling;Mouse Embryonic Stem Cells;Nervous System;Neuronal Differentiation;Neurons;neuropsychiatric disorder;Neurosciences;novel;Paper;Pathogenicity;Pattern;Phenotype;pleiotropism;predictive modeling;Process;programs;Publishing;reconstitution;recruit;Regulation;Regulatory Element;Research;Research Personnel;response;Rest;senior faculty;Series;Signal Induction;Signal Transduction;single cell sequencing;single-cell RNA sequencing;Specific qualifier value;synthetic biology;targeted delivery;Technical Expertise;Technology;Testing;Tissue-Specific Gene Expression;tool;transcription factor;Tretinoin;Variant;Work

PROJECT_TITLE: Dissecting the logic of mammalian gene regulation using synthetic biology and single-cell sequencing


ADMINISTERING_IC: AG

ED_INST_TYPE: SCH OF HOME ECON/HUMAN ECOLOGY

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences

ORG_CITY: FORT COLLINS

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: COLORADO STATE UNIVERSITY

ORG_STATE: CO

PHR: PROJECT NARRATIVE Double-stranded RNA is a potential contributor to brain inflammation in age-related diseases, but its involvement and regulation in aging and Alzheimer’s disease remain unknown. This project will examine the role of a regulator of double-stranded RNA (ADAR1) and its influence on brain function, inflammation and dementia, while also identifying the cellular origins of double-stranded RNA in this context. The proposed research may also identify potential therapeutic targets to combat brain inflammation with aging and Alzheimer’s disease.

PI_NAMEs: MCENTEE, CALI MADISON (contact)

PROGRAM_OFFICER_NAME: MARTIN, DAMALI

PROJECT_TERMS: adeno-associated viral vector;Adenosine;Age;age related neurodegeneration;age related neuroinflammation;age-related disease;aged;Aging;aging brain;aging mechanism;Alzheimer's Disease;Alzheimer's disease patient;Astrocytes;Award;Base Pairing;biobank;Bioinformatics;Biology;Blood;Brain;brain health;brain tissue;Cell Culture Techniques;Cells;Clinical Data;cognitive function;cognitive testing;Colorado;combat;Data;Data Set;Dementia;Development;doctoral student;Double Stranded RNA Virus;Double-Stranded RNA;dsRNA adenosine deaminase;Encephalitis;Environment;Enzymes;Event;experience;Fibroblasts;Funding;Gene Expression;Genes;Genome;Genomics;Gliosis;Goals;healthspan;Human;human disease;human subject;IFIH1;Immune;immune activation;Immunoprecipitation;Impaired cognition;Inflammation;Inflammatory;inflammatory marker;Inosine;Interferons;Investigation;knock-down;Laboratories;life span;Link;Measures;Mentors;Modeling;Molecular;mouse model;Mus;Nerve Degeneration;Neurodegenerative Disorders;Neuroglia;neuroinflammation;novel marker;old mice;older adult;pathogen;Pathway interactions;Pattern;pre-clinical;programs;Publishing;Regulation;Repetitive Sequence;Reporting;Research;Research Training;RNA Binding;RNA immunoprecipitation sequencing;Role;Scientist;Signal Transduction;skills;Small Interfering RNA;Source;Testing;Therapeutic;therapeutic target;Training;Transcript;transcriptome;transcriptome sequencing;transcriptomics;Translating;Translational Research;translational scientist;Tretinoin;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Role of ADAR1 and dsRNA in age-related neuroinflammation and Alzheimers disease


PI_NAMEs: ETTENSOHN, CHARLES A. (contact)

PROJECT_TERMS: Ally;Animals;Antibodies;Architecture;Bibliography;Biological;Biological Models;biological research;Biology;Collaborations;Communities;Comparative Study;Data;data management;Databases;Development;Developmental Process;EchinoBase;Echinodermata;Embryo;Embryonic Development;Ensure;Evolution;FAIR principles;Foundations;Future;Gene Expression;Gene Expression Profile;gene regulatory network;Genes;Genetic Transcription;Genome;Genomics;Goals;Grant;Guide RNA;Heart;Human Development;human disease;improved;Individual;journal article;life history;Link;Literature;member;Mining;Mission;model organism;model organisms databases;Modeling;Modernization;Names;Ontology;Organism;Paper;Play;programs;Publications;Publishing;Reagent;Regulatory Element;Research;Research Personnel;Resources;Role;scientific organization;Sea Urchins;Time;Tissues;tool;Vertebral column;Vertebrates;Work;XenBase

PROJECT_TITLE: Mining Information from Echinoderm Genomes and the Scientific Literature


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: MATHER

ORG_NAME: VA NORTHERN CALIFORNIA HEALTH CARE SYS

PHR: Project Narrative Stroke is the leading cause of chronic disability in the United States. Each year, approximately 795,000 strokes occur accounting for over half of all acute inpatient neurological admissions across both Veterans Affairs and civilian medical settings. Persons 45-64 years of age now account for approximately half of total stroke care costs, a shift heralding an urgent need for rehabilitation to not only reduce disability and attendant costs of care, but optimize stroke recovery for persons in the productive and vital years of their lives. As a result, there is a critical need to identify rehabilitation methods that promote genuine recovery. The current proposal investigates methods to optimize induction of neuroplasticity in an effort to enhance walking function in Veterans following stroke. We will test three approaches to delivering paired associative stimulation, a non-invasive form of neuromodulation with known influences on neuroplasticity.

PI_NAMEs: PATTEN, CAROLYNN  (contact)

PROJECT_TERMS: Accounting;Acute;Address;Admission activity;Adult;Age;Age Years;Ankle;Area;Behavioral;Biomechanics;care costs;Caring;Chronic;Chronic disability;chronic stroke;Clinical;Collaborations;Contralateral;Corticospinal Tracts;cost;Data;Demographic Factors;Development;disability;Dose;expectation;Failure;Flexor;follow-up;Functional disorder;Funding;Future;Gait;Gait speed;Goals;Guidelines;Health;Health Care Costs;Hip region structure;Hospitalization;Human;human subject;improved;Individual;Inpatients;Intervention;intervention effect;Kinetics;Knowledge;Lead;Learning;Lesion;Limb structure;Location;Measurable;Mechanics;Medical;Methodology;Methods;Motor;Motor Evoked Potentials;Movement;neural;neural correlate;Neurologic;Neuromechanics;Neuronal Plasticity;neuroregulation;novel;Outcome;Paresis;Persons;post stroke;Productivity;Recovery;Recovery of Function;rehabilitation strategy;Rehabilitation therapy;Research;Research Personnel;response;Rest;restoration;Sample Size;Speed;Statistical Computing;Stroke;stroke hemiparesis;stroke recovery;stroke rehabilitation;stroke survivor;Testing;Transcranial magnetic stimulation;United States;United States Department of Veterans Affairs;Veterans;Walking;walking speed;Work

PROJECT_TITLE: Paired Associative Stimulation to Facilitate Plantarflexor Power Following Stroke

STUDY_SECTION: RRDS

STUDY_SECTION_NAME: Rehabilitation Research and Development SPiRE Program[RRDS]


NIH_SPENDING_CATS: Bioengineering;Nanotechnology

ORG_CITY: BOSTON

ORG_DEPT: CHEMISTRY

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

ORG_STATE: MA

PHR: UV Plasmon-Enhanced Chiroptical Spectroscopy of Membrane-Binding Proteins Relevance to Public Health Membrane binding proteins have diverse important biological functions ranging from controlling signaling to regulating membrane fusion but are difficult to characterize with existing biophysical tools. This project develops electromagnetically enhanced chiroptical spectroscopies that can provide detailed structural information about membrane-binding proteins under physiological conditions and will, thus, lead to a greatly improved understanding of these important proteins with important disease diagnostic implications.

PI_NAMEs: REINHARD, BJOERN MARKUS (contact)

PROGRAM_OFFICER_NAME: YEH, ALVIN TIEN-WEI

PROJECT_TERMS: absorption;alpha synuclein;Aluminum;amphiphilicity;aqueous;Binding;Binding Proteins;Binding Sites;Biological;Biological Process;biophysical properties;biophysical tools;Buffers;Chemicals;chiral molecule;Circular Dichroism;Circular Dichroism Spectroscopy;Cryoelectron Microscopy;Crystallization;design;Disease;disease diagnostic;Electromagnetic Fields;Electromagnetics;Electronics;enantiomer;Engineering;Environment;Equilibrium;Frequencies;Goals;Gold;Higher Order Chromatin Structure;Hot Spot;improved;Individual;insight;instrument;interest;Investigation;Lead;Light;Lipids;Magnetism;Measurement;Membrane;membrane activity;Membrane Fusion;Membrane Lipids;Membrane Proteins;Methods;Microscope;miniaturize;Molecular;Molecular Structure;nano;nanoengineering;nanoparticle;Nanostructures;Nucleic Acids;Optics;Performance;Peripheral;Pharmacologic Substance;Phase;Physiological;plasmonics;Preparation;Property;protein structure;Proteins;prototype;Public Health;Raman Spectrum Analysis;Research;Sampling;Signal Transduction;Silver;small molecule;Spectrum Analysis;stereochemistry;Structure;Surface;Surface Plasmon Resonance;Surface Properties;Techniques;Temperature;temporal measurement;Tertiary Protein Structure;Testing;theories;tool;ultraviolet;Vibrational Circular Dichroism;X ray spectroscopy;X-Ray Crystallography


NIH_SPENDING_CATS: Clinical Research;Cost Effectiveness Research;Emergency Care;Health Services;Pediatric

PHR: PROJECT NARRATIVE Millions of children visit emergency departments each year with variable access to pediatric expertise, and it is currently unclear how the sickest children fare. Ensuring the best outcomes in pediatric acute care is a national public health priority and depends on understanding variability in hospital quality. To understand where in the nation outcomes could be improved, we will use sophisticated whole-nation network analysis to develop a comprehensive atlas of national pediatric acute care outcomes, which we will then use to compare outcomes in three of the most common serious pediatric diseases: appendicitis, neurotrauma, and sepsis.

PI_NAMEs: MICHELSON, KENNETH  (contact)

PROGRAM_OFFICER_NAME: JENKINS, TAMMARA L

PROJECT_TERMS: Accident and Emergency department;accurate diagnosis;acute care;Adult;Algorithmic Analysis;Appendicitis;Area;Atlases;care outcomes;care seeking;care systems;Caring;Child;Child Care;Child health care;Childhood;Communities;Comparative Effectiveness Research;Complex;Continuity of Patient Care;cost;Cost Analysis;Critical Illness;Critically ill children;Data;data quality;Data Set;Databases;Detection;Diagnosis;Disease;District of Columbia;Emergency Care;Emergency department visit;Emergency medical service;Emergency Medicine;Emergency Situation;Ensure;Epidemiology;Expenditure;experience;Family;Geographic Locations;Geography;health care service utilization;Health Service Area;Health Services;Healthcare;Hospitals;Human Resources;improved;improved outcome;Individual;Individual Adjustment;injured;Injury;innovation;Interdisciplinary Study;Knowledge;large scale data;Lead;Link;longitudinal database;Maps;Measurement;Measures;Methodology;Methods;Modeling;multilevel analysis;National Institute of Child Health and Human Development;Nervous System Trauma;Operative Surgical Procedures;Outcome;Outcome Measure;Pathway Analysis;Patient-Focused Outcomes;Patients;Pattern;Patterns of Care;pediatric emergency;pediatric patients;Performance;Physicians;Policy Maker;Population;population health;Positioning Attribute;Privatization;Protocols documentation;public health priorities;Quality of life;Readiness;Reporting;Research;Research Personnel;Resources;Risk;Risk Adjustment;Rural;Sepsis;Severity of illness;Small-Area Analysis;Strategic Planning;Structure;System;Translating;Trauma;Variant;Work

PROJECT_TITLE: Measuring and Mapping National Pediatric Acute Care Outcomes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HSS-B(91)S]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Clinical Research;Eczema / Atopic Dermatitis;Nutrition

ORG_DEPT: DERMATOLOGY

PHR: PROJECT NARRATIVE For the 32 million people in the U.S. currently living with atopic dermatitis (eczema), the waxing and waning course of their chronic disease is impossible to predict, does not respond uniformly to treatment, and results in substantial economic impact and decreased quality of life. Understanding drivers of the disease activity is essential to developing treatments, and sodium/salt consumption is a likely contributor. Using a new MRI technique to image sodium in the skin on a cohort of 90 older adult men and women followed for two years, we will test novel hypotheses about the role of dietary salt intake and skin barrier function on sodium storage in the skin and atopic dermatitis severity and persistence.

PI_NAMEs: ABUABARA, KATRINA ELAINE (contact)

PROGRAM_OFFICER_NAME: UNDALE, ANITA H

PROJECT_TERMS: Address;Affect;African American population;Age;aged;aptamer;Area;Atopic Dermatitis;Biological Markers;Black Populations;Blood;burden of illness;Cardiovascular Diseases;cardiovascular disorder epidemiology;Cells;Chronic;Chronic Disease;clinical phenotype;Clinical Research;Clinical Trials;cohort;Cohort Studies;Consumption;Cytometry;design;Development;Diet;dietary;dietary excess;Dietary Factors;dietary salt;Dietary Sodium;Disease;economic impact;Eczema;Enrollment;environmental change;Environmental Risk Factor;Epidemiological trend;Epidemiology;epidemiology study;experience;Food;Frequencies;Future;Goals;Heterogeneity;Hydration status;Hypertension;Image;Imaging Techniques;Immune;immune function;Immune System Diseases;Immunologic Stimulation;Immunology;immunomodulatory therapies;Immunosuppression;improved;Industrialization;Inflammation;Inflammatory;innovation;Intake;Intervention;Laboratories;lifestyle factors;Link;Longitudinal cohort study;Magnetic Resonance Imaging;Measures;men;Modeling;multidisciplinary;normal aging;novel;novel strategies;nutritional epidemiology;older adult;Organ;Participant;Pathway interactions;Patient-Focused Outcomes;Patients;Persons;Phenotype;Physiological;Physiology;Population;preservation;prevent;Process;Proteins;Proteomics;Pruritus;Quality of life;Questionnaires;recruit;Research;Research Personnel;Research Project Grants;response;Role;salt intake;salt sensitive;Severities;Skin;skin barrier;skin biopsy;skin disorder;skin lesion;Sodium;Sodium Chloride;Subgroup;systemic inflammatory response;Techniques;Testing;Th2 Cells;Time;Tissues;Translational Research;treatment response;Urine;Variant;Visit;Water;Waxes;Woman;Work

PROJECT_TITLE: Sodium in the Skin and Atopic Dermatitis: The SIS-AD Study

STUDY_SECTION: ACTS

STUDY_SECTION_NAME: Arthritis, Connective Tissue and Skin Study Section[ACTS]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Data Science;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

PI_NAMEs: VIZE, PETER D (contact)

PROJECT_TERMS: Architecture;ATAC-seq;Atlases;Award;base;Bioinformatics;biomedical scientist;Cells;Code;Collaborations;Communities;Computer software;Consultations;Consumption;Custom;Data;data access;data exchange;data modeling;data resource;data reuse;Data Set;database query;database schema;Databases;design;Development;EchinoBase;Echinodermata;Educational workshop;empowerment;flexibility;Funding;Future;Gene Expression;Genes;Genome;genome browser;genome resource;genome-wide;Genomic Segment;Genomics;Genus Mentha;Goals;Grant;Head;High-Throughput Nucleotide Sequencing;improved;Intuition;knowledgebase;Link;Literature;Machine Learning;Maps;member;Methods;middleware;migration;new technology;novel;Orthologous Gene;paralogous gene;Phase;Phenotype;Phylogenetic Analysis;Process;Regulatory Element;Research;Resources;single cell technology;single-cell RNA sequencing;Site;software development;Specific qualifier value;Surveys;symposium;Synteny;System;Technology;technology development;Testing;tool;transcriptome sequencing;Update;usability;Variant;Visualization;Visualization software;web app;web interface;web portal;Writing;XenBase

PROJECT_TITLE: Software Development to Enhance Echinobase


NIH_SPENDING_CATS: Biotechnology;Cardiovascular

ORG_DEPT: NEUROSURGERY

PHR: Project Narrative Anastasis is a newly discovered cell recovery phenomenon that enables dying cells to survive by reversing the apoptotic cell death process. The mechanisms and consequences of anastasis remain unclear. By developing a biosensor to detect anastasis in live animals, and identifying key regulators of anastasis, our project will develop critical tools and knowledge to study the physiological, pathological, and therapeutic implications of anastasis.

PI_NAMEs: TANG, HO LAM  (contact)

PROGRAM_OFFICER_NAME: MASKERI, BAISHALI

PROJECT_TERMS: Animals;Apoptosis;Apoptotic;Bioinformatics;Biosensor;Brain Injuries;cancer cell;Cancer cell line;cancer survival;cancer therapy;Cardiac Myocytes;CASP3 gene;Cell Death;Cell Death Induction;Cell Death Process;Cell Differentiation process;Cell Membrane Permeability;Cell Survival;Cells;Cessation of life;clinically relevant;Cytoprotection;Drosophila genus;egg;Embryonic Development;Event;Exhibits;Foundations;Genes;Genetic;Heart failure;Homeostasis;Human;In Vitro;in vivo;insight;Knowledge;Label;Mammalian Cell;Molecular;Morphology;mouse model;Mus;Neurons;novel;novel therapeutic intervention;Outer Mitochondrial Membrane;Pathologic;pharmacologic;Physiological;Play;Post-Translational Protein Processing;preservation;Proteins;Proteomics;Rattus;Recovery;Recurrence;Recurrent disease;Regulation;Role;small molecule;stable cell line;System;Testing;Therapeutic;therapeutic target;Tissues;tool;Xenograft procedure

PROJECT_TITLE: Anastasis: A Novel Cell Survival Mechanism

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


ORG_CITY: HANOVER

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: PROJECT NARRATIVE Eggs and oocytes are unusually large cells that have unique mechanisms for regulating their cell cycles. Several molecular pathways involved in human diseases, such as cancer, are used to control progression through these early developmental stages. The goal of this MIRA R35 project is to understand how cell size regulates cell cycle and developmental progression in these extreme cell types to uncover broader control principles that may be relevant to human health.

PI_NAMEs: AMODEO, AMANDA A (contact)

PROGRAM_OFFICER_NAME: WELLS, MELISSA LYNN

PROJECT_TERMS: Affect;Biogenesis;Biological Models;blastocyst;Cell Cycle;Cell Cycle Progression;Cell Cycle Regulation;cell growth;Cell model;Cell Nucleus;Cell Size;cell type;Cells;Cellular biology;Characteristics;Chromatin;Coupling;Cytoplasm;Development;DNA damage checkpoint;Drosophila genus;egg;Embryo;Embryonic Development;Goals;Growth;Health;Histone H3;Histones;Human;human disease;inhibitor;insight;Malignant Neoplasms;Measures;Molecular;Nuclear;Nurses;Oocytes;Oogenesis;Pathway interactions;Phosphotransferases;Polyploidy;prevent;Process;System;Tissue Microarray;Transcription Initiation;Work

PROJECT_TITLE: The coordination of cell size control and cell cycle regulation at developmental extremes


ORG_CITY: HOUSTON

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: LISTOS Narrative Our proposed project, LISTOS O cancer Mexico for Cancer Control - L everaging I mplementation S cience T o ptimize S trategies for Cancer Control will increase capacity for implementation science for control in Mexico and Latin America. The project proposes to establish a new center in and carry out two cancer control implementation science research projects: 1) Implementing colorectal cancer screening in publicly funded health systems in Mexico, and 2) Implementation of integrated care for rapid diagnosis of breast cancer in Mexico. The research projects and capacity building activities have the potential not only to advance the science of cancer control implementation, but most importantly, to reduce the burden of cancer in Mexico and Latin America.

PI_NAMEs: FERNANDEZ, MARIA EULALIA (contact);LAJOUS, MARTIN ;UNGER-SALDA�A, KARLA

PROGRAM_OFFICER_NAME: CORREA-MENDEZ, MARGARITA

PROJECT_TERMS: Acceleration;Address;Adoption;base;breast cancer diagnosis;Cancer Burden;Cancer Control;career;Collaborations;colorectal cancer screening;Communication;Consolidated Framework for Implementation Research;Country;design;Development;Diagnosis;Disparity population;Dissemination and Implementation;Effectiveness;Ensure;Equity;evidence base;Evidence based intervention;experience;follow-up;Funding;Generations;Goals;health inequalities;Health Services Accessibility;Health system;Healthcare Systems;Implementation readiness;implementation research;implementation science;implementation strategy;improved;Income;Infrastructure;innovation;Institution;integrated care;Interactive Systems Framework;Intervention;Language;Latin America;Latin American;Lead;Leadership;Learning;low and middle-income countries;Malignant Breast Neoplasm;Malignant Neoplasms;Maps;Measurement;Measures;Mentors;Mentorship;Methodology;Methods;Mexico;Modeling;Motivation;National Cancer Institute;next generation;organizational readiness;Pathway interactions;personalized approach;Persons;Population;Population Heterogeneity;Primary Care;Problem-Based Learning;programs;Public Health;public health insurance;rapid diagnosis;Readiness;Research;Research Personnel;Research Project Grants;research study;Research Support;Resources;scale up;Science;Scientist;Screening for cancer;Spanish;System;Testing;theories;tool;Training;Training Activity;Uninsured;uptake;Work

PROJECT_TITLE: LISTOS for Cancer Control - Leveraging Implementation Science To Optimize Strategies for Cancer Control


NIH_SPENDING_CATS: Biotechnology;Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

PROJECT_TERMS: Award;Code;code development;Communities;Complex;Computer software;computerized data processing;computing resources;Custom;Data;data exchange;data management;Databases;Development;diverse data;EchinoBase;Echinodermata;Ensure;Environment;FAIR principles;Future;Genes;Genome;Genomics;Goals;Hybrids;improved;Infrastructure;knowledgebase;Licensing;migration;Monitor;open source;open source tool;Performance;Privatization;Process;Production;Publications;Reporting;Research Personnel;Resources;response;Risk;Running;Secure;Services;System;Testing;Time;time use;tool;tool development;Update;virtual machine;web app;web interface;Work

PROJECT_TITLE: Computational Support for All Echinobase Objectives


NIH_SPENDING_CATS: Cancer;Clinical Research;Dissemination and Implementation Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Racial and Ethnic Minority Health Research

PI_NAMEs: FERNANDEZ, MARIA EULALIA (contact)

PROJECT_TERMS: Accountability;Address;Area;California;cancer care;Cancer Control;cohesion;Collaborations;Communication;community engagement;Community Health;Complex;Decision Making;Disparity;Ensure;Equity;experience;Goals;health organization;Health Sciences;Health system;implementation science;Infrastructure;insight;Institution;Intervention;Knowledge;Laboratories;Latin America;Latin American;Lead;Leadership;Learning;low and middle-income countries;Malignant Neoplasms;Mentorship;Mexican;Mexican Americans;Mexico;Mission;National Cancer Institute;operation;Pilot Projects;Policy Maker;Process;Public Health;Readiness;Research;Research Activity;Research Project Grants;Research Support;Resources;Role;San Francisco;Strategic Planning;success;Texas;United States;Universities;Vertebral column;Work

PROJECT_TITLE: Administrative and Engagement Core


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Genetics;Infectious Diseases;Networking and Information Technology R&D (NITRD);Rare Diseases

ORG_DEPT: ENGINEERING (ALL TYPES)

PHR: Project Narrative This project will build novel computational tools to measure, interpret, and predict basic biological dynamics of cell signaling, transcription and translation. When integrated with single-cell experiments, these tools will support national goals to seek predictive knowledge about the nature and behavior of living systems; to enable more rapid and cost-effective health-related discoveries; and to develop the human, physical and computational resources necessary to enhance the nation's ability to prevent and treat disease.

PI_NAMEs: MUNSKY, BRIAN  (contact)

PROGRAM_OFFICER_NAME: NGUYEN, HAN

PROJECT_TERMS: Affect;Bacterial Infections;Behavior;Biochemical;Biological;Biological Process;cancer therapy;Carcinoma;Cells;cellular imaging;Chromatin;Complex;Computer Models;computerized tools;Computing Methodologies;computing resources;cost effective;Data;data integration;data modeling;design;Diffusion;Disease;Enzymes;epigenetic memory;Escherichia coli;experimental analysis;Experimental Designs;experimental study;Fluorescence Microscopy;Gene Expression Regulation;Genes;Genetic Diseases;Genetic Transcription;Goals;Health;Human;Image;image processing;improved;Infection;inhibitor;insight;Knowledge;Label;Malignant Neoplasms;MAP Kinase Gene;markov model;Measurement;Measures;Messenger RNA;microscopic imaging;Modeling;Molecular;Molecular Machines;Morphologic artifacts;Nature;novel;Operon;Organism;Osteosarcoma;particle;Phosphorylation;Polymerase;Population;predictive modeling;prevent;Process;Reaction;Repression;Reproducibility;Research;Resources;Retinal Degeneration;RNA;SAGA;Signal Transduction;simulation;single molecule;skeletal dysplasia;spatiotemporal;Statistical Methods;Stress;Testing;tool;transcription factor;Transfer RNA;Translating;translation factor;Translations;Uncertainty;Variant;Viral;Work;Yeasts

PROJECT_TITLE: Integrating Multi-Scale Imaging, Reaction-Diffusion Simulation, and Markov Model Inference to Enhance Predictive Design and Interpretation of Single-Molecule Gene Regulation Experiments


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: PHILADELPHIA

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: DREXEL UNIVERSITY

PHR: NARRATIVE  This study will examine clinically-relevant rhythmogenic properties of spinal locomotor-related interneurons, including their intrinsic and local network rhythm-generating properties and how they are activated by neurons in the brainstem. Findings will provide essential insights and reveal potential therapeutic targets for the restoration of locomotor function to be used in the treatment of paralysis and disability that result from injury or disease.

PI_NAMEs: SINGH, SHAYNA  (contact)

PROGRAM_OFFICER_NAME: MATTHEWS, MARGUERITE

PROJECT_TERMS: Address;Adult;Anatomy;Brain Stem;Cell Nucleus;Cells;clinically relevant;combinatorial;Data;disability;Disease;Electrophysiology (science);excitatory neuron;experimental study;Frequencies;Future;Generations;Individual;Injury;innovation;insight;Interneurons;Ion Channel Gating;Lateral;Left;Light;Locomotion;Lumbar spinal cord structure;Maintenance;Mediating;Membrane Potentials;Modeling;Mus;Neurons;optogenetics;Paralysed;Parkinson Disease;patch clamp;Periodicity;pharmacologic;Population;Property;rabies viral tracing;recruit;Research;restoration;Role;SCN8A gene;Shapes;Signal Transduction;Slice;Sodium;Spinal;Spinal Cord;Spinal cord injury;Stroke;Suggestion;Synapses;synergism;System;targeted treatment;Testing;Therapeutic;therapeutic target;transcription factor;Transgenic Mice;transmission process;Traumatic Brain Injury;Traumatic CNS injury;voltage;Work

PROJECT_TITLE: Mechanisms of rhythm generation and recruitment in mammalian locomotor-related spinal interneurons


NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Dental, Oral, and Craniofacial Disease;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Neurosciences;Pediatric;Prevention;Women's Health Research

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE Findings from this study will lead to a more nuanced understanding of mechanisms underlying sex-specific trajectories of internalizing symptoms and help inform targeted early interventions. Specifically, results may identify sex-specific treatment targets and inform trials of personalized neuromodulatory therapies such as transcranial magnetic stimulation. Furthermore, predictors of longitudinal symptomatology could be used for treatment stratification in clinical trials using personalized biomarkers.

PI_NAMEs: SHANMUGAN, SHEILA  (contact)

PROGRAM_OFFICER_NAME: MILLER, BECKY

PROJECT_TERMS: Abbreviations;Acceleration;Adolescence;Adolescent;Age;American;Anatomy;Anxiety;Anxiety Disorders;Appointment;Area;Award;Biological;Brain;career;Childhood;clinical translation;Clinical Trials;Cognition;cognitive development;cognitive process;connectome;Data;data resource;Data Set;deep learning model;Dendritic Spines;density;Development;Disease;Disproportionately impacts women;Early identification;Early Intervention;Emotional;Estradiol;excitatory neuron;Female;Female Adolescents;follow-up;Funding;Future;Generalized Anxiety Disorder;Genes;Glutamates;Gonadal Steroid Hormones;Grant;high dimensionality;Human;indexing;Individual;innovation;Institution;inter-individual variation;Journals;Leadership;Link;Location;longitudinal course;Machine Learning;machine learning method;Major Depressive Disorder;male;Measures;Mediating;Mediation;Mental Depression;Mentorship;Methods;Modeling;Moods;National Institute of Mental Health;National Research Service Awards;Nature;Neuroanatomy;neuroimaging;neuromechanism;neuroregulation;Non-linear Models;Pattern;personalized biomarkers;Persons;Prevalence;Process;professor;prospective;Psychiatry;Psychopathology;psychosocial;Puberty;Publications;Publishing;Radiology Specialty;Recommendation;Research;Research Personnel;Research Project Grants;Risk;Risk Factors;Sampling;sex;sex as a biological variable;Sex Differences;Shapes;skills;Spatial Distribution;Surface;symptomatology;Symptoms;Technical Expertise;tenure track;Testing;Time;Training;Transcranial magnetic stimulation;treatment stratification;United States National Institutes of Health;Variant;Women's prevalence;Work;Youth

PROJECT_TITLE: Using person-specific networks to uncover sex differences in vulnerability to internalizing disorders


NIH_SPENDING_CATS: Cancer;Dissemination and Implementation Research;Prevention

PROJECT_TERMS: Active Learning;Address;Adoption;American;Cancer Burden;Cancer Control;Cancer Control Research Program;cancer prevention;career;career development;Caribbean region;certificate program;clinical practice;cohort;Collaborations;collaborative environment;Competence;Coupled;Development;Educational workshop;evidence base;Fostering;Funding;Generations;Goals;health care service organization;health inequalities;Health Policy;Implementation readiness;implementation research;implementation science;implementation strategy;improved;innovation;Institution;interest;Interview;Investments;Language;Latin America;Latin American;Latina;Leadership;leadership development;low and middle-income countries;Malignant Neoplasms;Measurement;meetings;member;Mentors;Mentorship;Methods;Mexican;Mexican Americans;Mexico;Modeling;Morbidity - disease rate;mortality;multimodality;novel;oral communication;organizational readiness;Output;Participant;Peer Review Grants;programs;Public Health;Publishing;Readiness;Research;Research Design;Research Personnel;Resources;Scientist;skills;Spanish;Statistical Methods;symposium;systematic review;tool;Training;Training Activity;training opportunity;Training Programs;Training Support;Writing

PROJECT_TITLE: Research Capacity Building Core


NIH_SPENDING_CATS: Bioengineering;Biotechnology

ORG_CITY: BLACKSBURG

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

ORG_STATE: VA

PHR: Project Narrative Ubiquitin ligases are enzymes that attach a protein signal called ubiquitin to specific proteins, which often results in the recycling of these proteins by the cell. Ubiquitin ligases are critical to the survival of all animals, plants, and fungi, and disruption of their function results in numerous diseases in humans including most cancers and neurodegenerative diseases. We study the molecular function of ubiquitin ligases to gain new insights into how they function and use them as a scaffold to engineer biosensors to study disease, engineer biological systems, and improve sustainable manufacturing of foods, fuels, pharmaceuticals, and other chemicals.

PI_NAMEs: WRIGHT, ROBERT CLAY (contact)

PROGRAM_OFFICER_NAME: PHILLIPS, ANDRE W

PROJECT_TERMS: Agriculture;Anabolism;Animals;Biological Assay;biological systems;Biology;Biomanufacturing;Biomedical Engineering;Biosensor;Blood Vessels;Cell Cycle Regulation;Cells;Chemical Engineering;Chemicals;Development;dietary supplements;Disease;Engineering;Environment;Enzymes;Eukaryota;Evolution;Food;fungus;Genetic Transcription;Growth;hormonal signals;Hormone Responsive;Hormones;Human;human disease;improved;Industrialization;Inflammation;insight;Malignant Neoplasms;manufacture;Metabolic;Metabolic Diseases;Microbe;Molecular;multicatalytic endopeptidase complex;mutation screening;Neurodegenerative Disorders;novel;pathogen;Pathway interactions;Peptides;Pharmacologic Substance;Physiology;Plant Growth Regulators;Plants;Play;prevent;Process;programs;protein degradation;Protein Engineering;Proteins;Proteome;Recycling;Research;Role;scaffold;Signal Pathway;Signal Transduction;Signaling Protein;Stress;System;tool;transcription factor;Ubiquitin;ubiquitin ligase

PROJECT_TITLE: Understanding and Engineering Chemically Activated Ubiquitin Ligases


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

PI_NAMEs: HINMAN, VERONICA FRANCES (contact)

PROJECT_TERMS: Address;Algorithms;ATAC-seq;Bioinformatics;Caring;Cells;ChIP-seq;Clustered Regularly Interspaced Short Palindromic Repeats;Communities;Data;Data Display;Data Set;data visualization;design;Development;Developmental Biology;EchinoBase;Echinodermata;Effectiveness;Elements;experimental study;functional genomics;Future;Gene Expression;Generations;Genes;Genetic Polymorphism;Genome;genome annotation;genome browser;genome sequencing;genomic data;Genomics;Guide RNA;high throughput screening;improved;indexing;Individual;Maps;Modeling;multiple data types;Oligonucleotides;Ontology;Orthologous Gene;Paper;Phenotype;Process;Proteome;Reagent;Recommendation;Regulatory Element;Repetitive Sequence;Research;Research Personnel;Resources;single cell technology;Source;Surveys;Technology;transcriptome;transcriptome sequencing;transcriptomics;Untranslated RNA;Visualization

PROJECT_TITLE: Improved Annotation of Echinoderm Genomic Features


NIH_SPENDING_CATS: Aging;Cancer;Clinical Research;Colorectal Cancer;Comparative Effectiveness Research;Cost Effectiveness Research;Digestive Diseases;Dissemination and Implementation Research;Health Services;Prevention;Primary Health Care

PI_NAMEs: LAJOUS, MARTIN  (contact)

PROJECT_TERMS: Address;Adoption;Adult;Age;arm;Breast Cancer Detection;Cancer Control;Cancer Etiology;Caring;Cellular Phone;Cervical Cancer Screening;Colonoscopy;Colorectal Cancer;colorectal cancer screening;cost;cost effective;cost effectiveness;Country;Death Rate;design;Development;Diagnostic;Dissemination and Implementation;Early Diagnosis;economic cost;economic evaluation;Effectiveness;effectiveness evaluation;effectiveness outcome;effectiveness/implementation study;Electronic Health Record;evidence base;Evidence based intervention;Family;Feedback;Funding;Gastroenterologist;Goals;Health Personnel;Health system;Healthcare;Healthcare Systems;Hybrids;implementation design;implementation facilitators;implementation outcomes;implementation research;implementation science;implementation strategy;improved;Incidence;incremental cost;Institution;Integrated Health Care Systems;Interruption;Intervention;Interview;Knowledge;Link;Local Government;Malignant Neoplasms;Maps;Measures;Medical Care Team;member;men;Methods;Mexican;Mexico;microcosting;Modeling;Morbidity - disease rate;mortality;organizational readiness;Patient Education;patient navigation;patient screening;Patients;Population;primary care clinician;Process;programs;prospective;Public Health;Records;relative cost;Research;Research Project Grants;research study;Resource-limited setting;Resources;retiree;Risk;Scientific Advances and Accomplishments;screening;Screening for cancer;screening guidelines;screening program;Series;Specialist;Standardization;Telephone;Testing;testing uptake;Texas;Text Messaging;Time;Training;virtual;Woman

PROJECT_TITLE: Research Project 1


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: ATHENS

ORG_NAME: UNIVERSITY OF GEORGIA

ORG_STATE: GA

PHR: PROJECT NARRATIVE Within a cell, organelles can communicate with each other via specialized protein structures called membrane contact sites (MCSs). MCSs play a crucial role in cellular homeostasis, but our knowledge about them is limited to a very narrow group of organisms. This research seeks to characterize MCSs in a branch of pathogenic protists that cause significant human diseases—such as malaria and toxoplasmosis—to understand how their unique organelles communicate with each other, and identify new targets for the development of anti-parasitic therapies.

PI_NAMEs: HUET, DIEGO  (contact)

PROGRAM_OFFICER_NAME: MACARTHUR, LINDA

PROJECT_TITLE: Understanding inter-organellar communication in apicomplexan parasites

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CDB-B(55)R]


PROJECT_TERMS: Adopted;Awareness;bioinformatics pipeline;Biological;Code;Collaborations;Communication;Communities;community engagement;Data;data management;data repository;data sharing;data submission;Databases;design;Destinations;Development;Developmental Biology;EchinoBase;Echinodermata;Education;Education and Outreach;Educational Materials;Educational process of instructing;Educational workshop;empowerment;Ensure;experience;FAIR principles;Feedback;Fostering;Future;Gene Expression Regulation;gene regulatory network;Genes;Genome;genome resource;genomic data;Genomics;Goals;Human Resources;improved;innovation;interest;Intuition;knowledgebase;Link;literacy;Marine Invertebrates;Measures;meetings;member;Methodology;model organism;Newsletter;Nomenclature;online resource;Ontology;outreach;Paper;Pathway Analysis;Persons;Policy Maker;posters;Productivity;program dissemination;Publications;Publishing;repository;Research;Research Personnel;Resources;Role;Sea Urchins;Site;Societies;Surveys;symposium;System;Technology;trend;Universities;Update;virtual;web-accessible;wiki

PROJECT_TITLE: Dissemination: Communication, Training and Outreach in Support of Enhanced Echinobase


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dental, Oral, and Craniofacial Disease;Mental Health;Neurodegenerative;Neurosciences;Parkinson's Disease

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE Parkinson’s disease affects millions of individuals worldwide and causes progressive abnormalities in movement as well as changes in motivation such as apathy and impulsivity. The goal of this research is to understand the brain mechanisms underlying these impairments in motivation by probing brain networks at high resolution. This work may lead to new and precise strategies to treat these non-motor symptoms of Parkinson’s disease.

PI_NAMEs: FERENCZI, EMILY ANNE (contact)

PROJECT_TERMS: Address;Affect;Area;Back;Basal Ganglia;Behavior;Behavior Control;Behavioral;Brain;brain abnormalities;Brain region;cell type;Cells;Clinical;Clinical Management;clinical training;Cues;design;Development;Disabling;disease model;Disinhibition;driving behavior;effective therapy;Electrophysiology (science);Environment;Exhibits;experience;Financial Support;Ganglia;Globus Pallidus;Goals;Hearing;Impairment;Impulsivity;in vivo;Individual;ineffective therapies;innovation;innovative technologies;Institution;Intervention;Knowledge;Laboratories;Leadership;Learning;Link;Mentors;Mentorship;millisecond;Modeling;Monitor;motivated behavior;Motivation;mouse model;Movement;Movement Disorders;Mus;Nerve Degeneration;neural;neural circuit;Neurodegenerative Disorders;Neurologic;Neurology;Neurons;neuropsychiatric disorder;neuropsychiatric symptom;neuroregulation;Neurosciences;new therapeutic target;non-motor symptom;novel;Operant Conditioning;Operative Surgical Procedures;optogenetics;Parkinson Disease;Parkinsonian Disorders;Pathologic;Pathology;Patients;Pattern;Persons;Pharmaceutical Preparations;Pharmacologic Substance;Phenotype;Physiological;Population;Program Development;programs;Regulation;Research;Research Personnel;Resolution;restraint;Rewards;Rodent Model;Role;Signal Transduction;skills;symptom treatment;Symptoms;Teacher Professional Development;Techniques;technology training;temporal measurement;Testing;therapeutic target;therapeutically effective;tool;Training;Translating;Water;Work

PROJECT_TITLE: Deciphering Neuronal Control of Behavioral Initiation and Suppression


NIH_SPENDING_CATS: Regenerative Medicine

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

PHR: PROJECT NARRATIVE The proposed research will tackle a challenge central to public health: understanding the essential cellular and molecular mechanisms controlling tissue degeneration, regeneration and return to homeostasis in vertebrates. Using a model system that provides natural and cyclical tissue degeneration and regeneration, these efforts will investigate mechanisms underlying fundamental problems in tissue patterning and homeostasis, as well provide insight into pathological states of hypertrophy and degenerative disease and repairing lost or damaged tissue through regenerative medicine.

PI_NAMEs: LARSON, TRACY ALISON (contact)

PROGRAM_OFFICER_NAME: SALAZAR, DESIREE LYNN

PROJECT_TERMS: Anatomy;Behavior;Biological Models;Birds;Breeding;Cell Death;Cell Survival;Cells;Clinical;Competence;Crowns;Degenerative Disorder;Equilibrium;Event;experimental analysis;functional restoration;Generations;Genetic;genetic variant;Genomic approach;Goals;Growth;Histologic;Homeostasis;Hypertrophy;Individual;insight;Knowledge;Link;Literature;Modeling;Modification;Molecular;Mutation;Natural History;Natural regeneration;Nerve Regeneration;neural circuit;neural growth;novel;Outcome;Pathologic;Pattern;pharmacologic;Population;prevent;programs;Proliferating;Public Health;regenerative;Regenerative Medicine;Regenerative research;repaired;Research;Seasonal Variations;Seasons;Serinus;Songbirds;Sparrows;Specific qualifier value;Stereotyping;System;Testing;tissue degeneration;tissue regeneration;Tissues;Translating;Vertebrates;Work

PROJECT_TITLE: Mechanisms of cyclical degeneration and regeneration in an avian model system


NIH_SPENDING_CATS: Breast Cancer;Cancer;Clinical Research;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Primary Health Care;Women's Health Research

PI_NAMEs: UNGER-SALDA�A, KARLA  (contact)

PROJECT_TERMS: Address;advanced disease;Area;Breast;breast cancer diagnosis;Breast Cancer Patient;Breast Cancer Treatment;cancer care;Cancer Center;Cancer Control;cancer diagnosis;Capital;care delivery;Caring;Case Manager;Cities;Clinic;Clinical;Collaborations;Consultations;cost;Country;Death Rate;design;Diagnosis;Diagnostic;diagnostic platform;Diagnostic Services;effectiveness evaluation;effectiveness outcome;effectiveness/implementation study;experience;Face;Focus Groups;follow-up;Funding;Goals;Government;Health Care Costs;Health Personnel;Health system;Healthcare;Healthcare Systems;Home;Human Resources;Hybrids;Image;implementation barriers;implementation design;implementation facilitators;implementation fidelity;implementation outcomes;Implementation readiness;implementation science;implementation strategy;improved;Income;innovation;Institution;integrated care;Intervention;Interview;Language;Latin American;low and middle-income countries;Malignant Breast Neoplasm;Malignant Neoplasms;Mammographic screening;Maps;Measures;Medical;Mentors;metropolitan;Mexican;Mexico;organizational readiness;Outcome;Pathology;Patient-Focused Outcomes;Patients;Population;Primary Care;primary care clinic;primary care setting;programs;Protocols documentation;Public Health;Quality of life;Randomized;rapid diagnosis;Rapid diagnostics;Recommendation;Research Project Grants;Resources;screening;Spanish;Structure;Symptoms;System;Systems Integration;Testing;Time;treatment services;Uninsured;uptake;Woman;World Health Organization

PROJECT_TITLE: Research Project 2


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Microbiome;Social Determinants of Health

ORG_CITY: MADISON

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: NARRATIVE Psychosocial stress and voice problems are inevitably linked, however, the underlying biological mechanisms governing this relationship remain understudied. The microbiome is a key regulator of the psychosocial stress response, with deleterious, stress-induced changes to epithelial barrier integrity. This proposal will investigate the microbial and epithelial consequences of psychosocial stress in the larynx.

PI_NAMEs: VENKATRAMAN, ANUMITHA  (contact)

PROGRAM_OFFICER_NAME: SCHURMAN, JACLYN REBECCA

PROJECT_TERMS: 16S ribosomal RNA sequencing;Acoustics;Aerobic;Bacteria;Bacterial Translocation;Biological;biological adaptation to stress;Biology;Brain;Chronic;Collection;Data;Development;Down-Regulation;dysbiosis;Epithelial Cell Junction;Epithelium;Exhibits;experimental study;Exposure to;Fellowship;Fluorescent in Situ Hybridization;Functional disorder;Future;Gene Expression;Genes;gut microbiota;Immunofluorescence Immunologic;Immunohistochemistry;Infection;injury recovery;Knowledge;Laryngeal Epithelium;Larynx;Lead;Link;mechanical stimulus;Mediating;Membrane;Methodology;Microbe;microbial;microbial community;microbial composition;microbial host;Microbiology;microbiome;microbiota;mouse model;Mucins;mucosal microbiota;Mucous body substance;Mucous Membrane;Mus;National Research Service Awards;Organ;Outcome;pathogenic bacteria;Pathology;Patients;Periodicals;Permeability;Personality Traits;Polymerase Chain Reaction;Predisposition;probiotic therapy;Probiotics;Proliferating;Protocols documentation;Psychological Stress;Psychosocial Influences;Psychosocial Stress;Reporting;Research;response;restraint stress;Role;Sampling;sex;skills;Social Behavior;Stains;Stomach;Stress;Stressful Event;targeted treatment;Therapeutic Intervention;Thick;Time;Tissues;Treatment/Psychosocial Effects;vocal cord;Voice;Voice Disorders

PROJECT_TITLE: Investigating the effects of psychosocial stress on laryngeal microbiology and epithelial barrier integrity


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Data Science;Emerging Infectious Diseases;Genetics;Human Genome;Infectious Diseases;Networking and Information Technology R&D (NITRD)

ORG_CITY: MENLO PARK

ORG_NAME: SRI INTERNATIONAL

PHR: Project Narrative Escherichia coli is the most thoroughly studied bacterium on earth; therefore, a computer knowledgebase that in- tegrates experimental ﬁndings for this organism from thousands of scientiﬁc publications is a valuable and cost- effective resource for science and education. The comprehensive knowledge and computational tools available through EcoCyc accelerate the research of scientists who use this organism to develop biofuels, of scientists who study related pathogenic bacteria, and of scientists who work with the bacteria comprising the human microbiome.

PI_NAMEs: KARP, PETER D (contact)

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TERMS: Acceleration;Acetylation;anti-microbial drug;Australia;Bacteria;Biochemical Pathway;Bioinformatics;Biomedical Research;Chemicals;Climate;Collection;Communities;Companions;Complex;Computational Biology;Computer software;computerized tools;Computers;Computing Methodologies;Consult;cost effective;Data;Data Collection;Data Files;Data Set;Databases;Discipline;Documentation;drug discovery;Education;Ensure;Epigenetic Process;Escherichia coli;Escherichia coli O157:H7;Escherichia coli Proteins;experimental study;falls;functional genomics;Funding;Future;gene product;Genes;Genetic;Genome;genome annotation;Gram-Negative Bacteria;Growth;Human Microbiome;improved;Information Resources;innovation;International;Internet;Knock-out;Knowledge;knowledge integration;knowledgebase;Letters;Literature;Metabolic;metabolic engineering;Metabolic Pathway;Metabolism;Methods;Mexico;Microbiology;Mission;model development;model organism;model organisms databases;Modeling;Molecular Machines;Nutrient;operation;Operon;Organism;Orthologous Gene;outreach;pathogenic bacteria;pathway tools;phenotypic data;Planet Earth;predictive modeling;Process;Production;promoter;Proteins;Publications;Publishing;quality assurance;Reaction;Regulation;Request for Applications;Research;Research Personnel;Resources;Science;Scientist;Shiga Toxin;Site;software development;Software Tools;Source;System;Time;tool;Training;Triage;United States National Institutes of Health;Universities;Update;Validation;Visit;Visualization;web site;Work;Writing

PROJECT_TITLE: Knowledgebase of Escherichia coli Genome and Metabolism


ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Narrative Our purpose is to understand the molecular processes that control the gout flare with our research plan based on an inflammatory pathway we identified from a very large genome-wide association study in gout. In our research we will study the genetic regulation of the pathways in experimental systems (including a zebrafish model of gout and human cell lines), we will determine how gout risk genotype changes gene expression and the epigenome in immune cells from volunteers and cell lines, and we will study how a particular class of gene that doesn’t code for protein (‘lncRNA’) controls expression of immunomodulatory genes in gout.

PI_NAMEs: MERRIMAN, TONY R (contact)

PROGRAM_OFFICER_NAME: PARK, HEIYOUNG

PROJECT_TERMS: Acute;Address;Adult;Affect;African American;Alabama;Ankylosing spondylitis;Architecture;Area;Biological Assay;Candidate Disease Gene;candidate identification;Cardiometabolic Disease;caucasian American;Cell Line;cell type;Cells;chromatin isolation by RNA purification sequencing;Chromosome Structures;Chromosomes, Human, 6-12 and X;Clinical;Code;comorbidity;Consent;CTLA4-Ig;Deposition;Development;DNA Methylation;drug development;Drug Targeting;druggable target;Enhancers;Epigenetic Process;epigenome;epigenomics;experience;Family;Flare;follow-up;Future;gene conservation;Gene Expression;Gene Expression Regulation;Genes;Genetic;genetic association;Genetic Processes;Genetic study;Genetic Transcription;genetic variant;genome wide association study;genomic locus;Genomics;Genotype;Gout;Health;Hematopoiesis;Hi-C;histone modification;Human;Human Cell Line;Hyperuricemia;Immune;Immune response;Immunity;immunoregulation;improved;Individual;Inflammasome;Inflammation;Inflammatory;Inflammatory Response;Injections;Innate Immune System;innovation;insight;International;Joints;knock-down;Knock-out;Knowledge;Larva;Leukocytes;Link;locked nucleic acid;Macrophage;Mediating;Metabolism;Methylation;Modeling;Modification;Molecular;Molecular Conformation;Molecular Genetics;monocyte;neutrophil;new therapeutic target;novel;novel strategies;Nucleic Acid Regulatory Sequences;overexpression;Participant;Pathway interactions;Persons;physical symptom;Population;Predisposition;prevent;Process;Production;promoter;Proteins;psychologic;recruit;Regulation;Research;Research Design;Resources;response;Rheumatoid Arthritis;risk variant;RNA Binding;Role;screening;Secondary to;Severities;Signal Transduction;Site;social;Stimulus;System;targeted treatment;Testing;Therapeutic;Training;transcriptome;transcriptome sequencing;Translating;translational genomics;Translations;Untranslated RNA;Urate;validation studies;Variant;volunteer;Work;Zebrafish

PROJECT_TITLE: Translational genomics in gout: From GWAS signal to mechanism

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Digestive Diseases;Genetics;Human Genome;Orphan Drug;Ovarian Cancer;Pancreatic Cancer;Precision Medicine;Rare Diseases;Women's Health Research

ORG_NAME: FRED HUTCHINSON CANCER CENTER

PHR: PROJECT NARRATIVE Because each patient’s tumor is unique, treatments should be tailored to individual patients. We will develop a patient-centric approach that integrates novel experimental and computational methods using patient derived tumor cells to identify novel drug targets and potentially effective drugs and drug combinations. Identifying targets and effective drugs directly in patient derived samples with known clinical history will significantly enhance translation of our findings leading to improved clinical outcomes.

PI_NAMEs: KEMP, CHRISTOPHER J (contact)

PROGRAM_OFFICER_NAME: MCCARTHY, CLAIRE ELLEN

PROJECT_TERMS: Acceleration;Adjuvant Chemotherapy;Affect;Anatomy;Area;Biliary Tract Cancer;Biological Assay;Biological Markers;Biology;Cancer Biology;Cancer Etiology;cancer genetics;Cancer Patient;cancer type;Cells;Chemicals;chemotherapeutic agent;chemotherapy;Clinic;Clinical;Clinical Laboratory Improvement Amendments;Clinical Oncology;Clinical Research;Clinical Trials;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;Computational Biology;computerized tools;Computing Methodologies;computing resources;Credentialing;Data;Data Set;Dependence;Derivation procedure;Development;Drug Combinations;drug development;Drug resistance;drug resistance development;Drug Screening;drug sensitivity;Drug Targeting;Drug usage;effective therapy;Environment;Epigenetic Process;epigenetic profiling;epigenomic profiling;Evolution;functional genomics;Future;gemcitabine;Gene Expression;Genetic;genetic analysis;Genetic Markers;Genomics;Goals;improved;In Situ;individual patient;innovation;insight;Lethal Genes;Letters;Malignant neoplasm of ovary;Malignant neoplasm of pancreas;Malignant Neoplasms;Methodology;Methods;Modeling;Molecular Genetics;Molecular Profiling;mortality;Multiomic Data;Mutation;Neoadjuvant Therapy;neoplastic cell;new therapeutic target;novel;Oncogenic;Oncologist;Oncology;Organoids;Outcome;pancreatic cancer patients;Pancreatic Ductal Adenocarcinoma;patient response;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;Phenotype;Poly(ADP-ribose) Polymerase Inhibitor;pre-clinical;precision medicine;precision oncology;predictive modeling;pressure;prospective;protein degradation;Proteomics;Public Domains;Recording of previous events;refractory cancer;Research;Resistance;Resistance development;Resource Sharing;Resources;Role;Sampling;Serous;Site;small molecule;small molecule inhibitor;Stable Disease;standard of care;Surgical Oncology;System;targeted agent;targeted treatment;Technology;Testing;therapeutically effective;tool;Translating;Translations;Treatment Failure;tumor;tumor heterogeneity;Validation;Work

PROJECT_TITLE: A Patient-Centric Approach to Advance Functional Precision Oncology


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Neurosciences;Substance Misuse

ORG_CITY: CHARLESTON

ORG_DEPT: NEUROSCIENCES

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: PROJECT NARRATIVE Alcohol use disorder (AUD) is characterized by excessive consumption of alcohol, frequently in a compulsive manner to avoid the negative affective state that arises during withdrawal. The goal of this proposal is to determine if astrocytes within the lateral orbitofrontal cortex contribute to escalated drinking following the development of dependence. These studies will further elucidate the role of astrocytes and neurons in the lateral orbitofrontal cortex in dependence and withdrawal to provide insight on future therapeutic interventions.

PI_NAMEs: BLASCZYK, ABIGAIL RILEY (contact)

PROGRAM_OFFICER_NAME: CUI, CHANGHAI

PROJECT_TERMS: Action Potentials;Acute;Affect;aged;Agonist;Air;Alcohol consumption;Alcohol dependence;alcohol effect;alcohol exposure;alcohol research;alcohol use disorder;Alcohols;Astrocytes;Bilateral;Brain region;Calcium;Calcium Signaling;career;career development;Categories;Cell membrane;Cells;Chronic;Consumption;Data;Dependence;Development;Diagnosis;Dopamine D1 Receptor;dopamine D5 receptor;drinking;Drug Addiction;Electrophysiology (science);Ethanol;experimental study;Female;Fiber;Future;Glycine;Glycine Receptors;glycine transporter;Goals;Health;Heavy Drinking;Helping Behavior;hippocampal pyramidal neuron;Home;Impairment;in vivo;Individual;Infusion procedures;inhibitor;insight;Laboratories;Lateral;Learning;male;Manuscripts;Measures;Membrane Potentials;Modeling;Monitor;Mus;negative affect;Neurobiology;neuron loss;neuronal excitability;Neurons;novel;Operative Surgical Procedures;Opsin;optogenetics;overexpression;patch clamp;Persons;Phase;Photometry;Physiology;Play;PMCA1 protein;Positioning Attribute;Potassium Channel;Preparation;prevent;Process;Productivity;Quinine;Recreation;redshift;Reporter;research study;Resistance;response;responsible research conduct;Rest;Role;Slice;social;Strychnine;Substance Use Disorder;Techniques;Testing;Therapeutic Intervention;Training;United States;Viral;Virus;Water;Withdrawal

PROJECT_TITLE: The role of lateral orbitofrontal cortex astrocytes in alcohol drinking


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Brain Disorders;Breast Cancer;Cancer;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Neurosciences;Pain Research;Palliative Care;Prevention;Racial and Ethnic Minority Health Research;Rehabilitation;Social Determinants of Health;Women's Health Research

ORG_CITY: AUSTIN

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

PHR: This study will provide a prototype of a culturally tailored technology-based program for pain management of Asian American breast cancer survivors with depressive symptoms. This study will accelerate the translation of technology-based programs into health care and will be an important contribution in pain management of cancer survivors with depressive symptoms. Ultimately, this study will contribute to reducing ethnic disparities in health/disease experience by providing directions for culturally competent health care services, specifically for adequate pain and symptom management of racial/ethnic minority cancer survivors.

PI_NAMEs: CHEE, WONSHIK ;IM, EUN-OK  (contact)

PROGRAM_OFFICER_NAME: STRECK, BRENNAN PARMELEE

PROJECT_TERMS: Acceleration;active control group;addiction;Address;Adopted;Analgesics;Asian Americans;Attitude;authority;Biological Markers;Breast Cancer Risk Factor;Breast Cancer survivor;Cancer Center;cancer pain;Cancer Pain Management;Cancer Patient;Cancer Survivor;Chinese;chronic pain;Communities;Computer software;Computers;Control Groups;Cost Analysis;cost effectiveness;COVID-19 pandemic;Creativeness;cultural competence;Data;depressive symptoms;design;Deterioration;Devices;digital;Dimensions;Disease;East Asian;Education;efficacy evaluation;efficacy testing;ethnic health disparity;ethnic minority;Ethnic Origin;evidence base;experience;Family history of;Family member;Fatigue;flexibility;follow-up;Fright;Gatekeeping;Genetic;Goals;group intervention;handheld mobile device;Health;health care service;health care settings;Healthcare;help-seeking behavior;high risk;improved;Individual;innovation;Institute of Medicine (U.S.);Internet;Intervention;intervention effect;Intervention Studies;Japanese;Koreans;Language;Malignant Breast Neoplasm;Malignant Neoplasms;Managed Care;Measures;Mediating;Mental Depression;Methods;Modality;Oncology;Operating System;opioid epidemic;Outcome;Outcome Study;Pain;Pain management;Patient Self-Report;pharmacologic;Phase;phase 2 study;pilot test;Population;Prevalence;primary outcome;Process;programs;prototype;Quality of life;Race;racial minority;Randomized;Relative Risks;Reporting;Research;Running;Self Efficacy;Sleep disturbances;social health determinants;social influence;social stigma;Stigmatization;Stoicism;Stress;Stress and Coping;Subgroup;Survival Rate;Survivors;survivorship;symptom management;Symptoms;Technology;technology intervention;Testing;theories;therapy development;Time;Translating;Translations;treatment as usual;usability;web app;web server;Work

PROJECT_TITLE: Cancer Pain Management: A Technology-Based Intervention for Asian American Breast Cancer Survivors


NIH_SPENDING_CATS: Aging;Data Science;Genetics;Machine Learning and Artificial Intelligence;Prevention

ORG_CITY: Newark

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: PROJECT NARRATIVE DNA methylation age, a good reflection of the human aging process, has been used to predict chronological age and aging-related diseases. Developing a transfer learning framework to refine existing age prediction models and construct prediction intervals will increase the adaptability and interpretability of these epigenetic clocks.

PI_NAMEs: LUO, LAN  (contact)

PROGRAM_OFFICER_NAME: TSAP, LEONID V

PROJECT_TERMS: Adolescent;Adult;Age;age acceleration;age related;age related biomarkers;age-related disease;Aging;aging biomarker;aging clocks;aging process;aging related;aging related disease;Algorithms;Biological Aging;Biological Process;Birth;Calibration;Cells;Cessation of life;Child;Chronology;clinical decision-making;cohort;Communication;Communities;Computer software;Confidence Intervals;Data;Data Set;Data Sources;Decision Making;design;Disease;DNA Methylation;Educational Status;Elasticity;Environmental Risk Factor;Epigenetic age;epigenetic clock;epigenome;ethnic diversity;Evaluation;Exhibits;Exposure to;Goals;Health;healthspan;Heterogeneity;heterogenous data;high dimensionality;Human;Impaired cognition;improved;Individual;innovation;inter-individual variation;Intervention;Knowledge;Learning;Linear Regressions;Methods;Modeling;Outcome;outcome prediction;Performance;Population Heterogeneity;predictive modeling;Predisposition;prevent;Probability;Procedures;racial diversity;Reproducibility;Research;Research Project Grants;Risk Factors;Science;Site;Specific qualifier value;study population;Target Populations;Tissues;Training;training data;transfer learning;Uncertainty;Update;Validation;Work

PROJECT_TITLE: Transfer learning and uncertainty quantification in epigenetic clocks

STUDY_SECTION: ASPA

STUDY_SECTION_NAME: Analytics and Statistics for Population Research Panel A Study Section[ASPA]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Brain Disorders;Cerebral Palsy;Clinical Research;Clinical Trials and Supportive Activities;Intellectual and Developmental Disabilities (IDD);Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Physical Rehabilitation;Rehabilitation

ORG_CITY: NORTHRIDGE

ORG_NAME: SPINEX, INC.

ORG_STATE: CA

PHR: Narrative Currently prescribed treatments for children with cerebral palsy are often invasive or make irreversible changes to the neuromuscular system that may have long-term detrimental impacts on function. Noninvasive transcutaneous spinal neuromodulation using SCIPTM device paired with activity-based neurorehabilitation therapy (ABNT) has the potential to improve function and quality of life for children with cerebral palsy .

PI_NAMEs: GAD, PARAG  (contact)

PROGRAM_OFFICER_NAME: AJISAFE, TOYIN DELE

PROJECT_TERMS: 21 year old;Address;Adult;Affect;Age;aged;Agreement;Botulinum Toxin Type A;Brain;Breakthrough device;Cardiovascular system;Caring;Cerebral Palsy;Child;Childhood;Classification;Clinical;Clinical Research;clinically significant;Communication;design;Development;Devices;Diagnosis;Double-Blind Method;Epilepsy;Equilibrium;Esthesia;Etiology;Feedback;follow-up;Functional disorder;functional electrical stimulation;functional improvement;Future;Impaired cognition;Impairment;improved;Individual;information processing;innovation;International;Intervention;Intramuscular Injections;Life;Maintenance;Measures;meetings;Motor;Motor Activity;Motor disability;Movement;Muscle;Muscle function;Musculoskeletal;Nervous System Physiology;neural;neural circuit;neural network;Neurogenic Bladder;Neurologic;neurological rehabilitation;neuromuscular plasticity;neuromuscular system;neuroregulation;novel therapeutics;Operative Surgical Procedures;Outcome;Pain;Pain management;Parents;Pathway interactions;Pediatrics;Perception;Persons;Pharmaceutical Preparations;Physical therapy;Physiological;Pilot Projects;pilot trial;Population Study;Posture;Prevalence;primary outcome;Procedures;Proprioception;prospective;Quality of life;Randomized, Controlled Trials;recruit;rehabilitation strategy;Reporting;response;Rhizotomy procedure;Risk;Safety;Sample Size;secondary outcome;Sensorimotor functions;sensory input;Severities;skills;Spastic Cerebral Palsy;spasticity;Spinal;Spinal Cord;Spinal cord injury;spinal nerve posterior root;standard of care;Statistical Data Interpretation;symptom management;Symptoms;Testing;Therapeutic;therapy design;Time;transcutaneous stimulation;Update;usability

PROJECT_TITLE: Spinal Cord Innovation in Pediatrics to Treat Cerebral Palsy (SCiP Clinical Study)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-NV-C(10)B]