NIH_SPENDING_CATS: Data Science;Networking and Information Technology R&D (NITRD);Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn

PHR: Project Narrative The Center for Leadership in Environmental Awareness and Research (CLEAR) has built an integrated, transdisciplinary framework, rooted in advanced techniques in environmental engineering and biomedical research, to address human exposures to volatile organic compounds (VOCs) and health risks—for preterm birth in particular—in urban areas. CLEAR research is expected to have a direct impact on affected communities, stakeholders, and the agencies responsible for Superfund site management and reduction of environmental VOC exposure. The Data Management and Analytics Core will provide integrated data and biostatistics/informatics services that promote scientific synergy across CLEAR projects and cores, ensure data quality assurance and quality control, and foster data sharing and interoperability.

PI_NAMEs: LU, MEI  (contact)

PROJECT_TERMS: Address;Affect;analytical method;Area;Awareness;Bioinformatics;Biomedical Research;Biometry;Birth;Birth Rate;Cities;Collaborations;Communication;Communities;Complex;complex data;cost;dashboard;Data;Data Analyses;Data Analytics;Data Collection;Data Coordinating Center;data infrastructure;data integration;data interoperability;data management;Data Management Resources;data quality;Data Set;data sharing;Data Storage and Retrieval;Dedications;design;Development;Doctor of Philosophy;Educational workshop;Emerging Technologies;Engineering;Ensure;Environment;Environmental Engineering technology;Environmental Health;Environmental Science;Etiology;Evaluation;experience;exposed human population;Exposure to;FAIR principles;flexibility;Fostering;Geographic Information Systems;Goals;ground water;Growth;Health;Health system;Human;Industrialization;Informatics;Infrastructure;innovation;insight;Institution;interoperability;Knowledge;Leadership;Location;Machine Learning;Maps;Mentors;Methodology;Michigan;migration;model organism;multidimensional data;Mus;next generation;novel;offspring;Outcome;outreach services;Pathway Analysis;Plants;Premature Birth;Procedures;programs;Property;public health research;quality assurance;Quality Control;remote sensing;Reproducibility of Results;Research;Research Design;Research Project Grants;Risk;Sampling;Scientist;Secure;Services;Site;skills;Soil;Source;statistics;success;Superfund;superfund site;synergism;systems research;Techniques;Testing;Time;Training;United States Environmental Protection Agency;Universities;urban area;user-friendly;vapor intrusion;volatile organic compound;web-accessible;Zebrafish

PROJECT_TITLE: Data Management & Analysis Core


ADMINISTERING_IC: MH

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric

ORG_CITY: EAST LANSING

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOCHEMISTRY

ORG_FIPS: US

ORG_NAME: MICHIGAN STATE UNIVERSITY

ORG_STATE: MI

PHR: Project Narrative Autism spectrum disorder (ASD) is a clinically heterogeneous neurodevelopmental disorder that is associated with various gene mutations, including ASH1L (Absent, Small, or Homeotic discs 1-Like) gene that encodes a histone methyltransferase with its function in facilitating gene expression through epigenetic modification of chromatin. To understand the epigenetic mechanisms underlying ASH1L’s function in ASD pathogenesis, we will use an Ash1l-knockout-induced ASD mouse model to examine the function, transcriptome, and epigenome of cortical excitatory neurons, inhibitory neurons, and astrocytes in the mouse brain. The success of this project will not only largely advance our understanding of basic epigenetic mechanisms in autism pathogenesis, but also potentially lead to the development of new therapeutic approaches to treat ASD.

PI_NAMEs: HE, JIN  (contact)

PROGRAM_OFFICER_NAME: LEINWAND, SARAH GOLDBERG

PROJECT_TERMS: Acetyltransferase;Address;Area;ASD patient;ASH1L gene;Astrocytes;autism spectrum disorder;autistic;autistic behaviour;Behavioral;Biochemical;Biological Assay;Brain;Case Study;causal variant;Cells;Child;Chromatin;chromatin modification;Clinical;Cognitive;cohort;Complex;conditional knockout;Convulsants;craniofacial;CREBBP gene;Defect;Development;Diagnosis;disorder risk;Epigenetic Process;epigenetic regulation;epigenome;Epilepsy;Equilibrium;excitatory neuron;Gene Expression;Gene Mutation;gene network;Genes;Genetic;Genetic study;genome-wide;HDAC4 gene;Histone Acetylation;Histone Deacetylase Inhibitor;Histone H3;histone methyltransferase;histone modification;Histone-Lysine N-Methyltransferase;Histones;Hyperactivity;Impairment;In Vitro;Individual;Induced Mutation;inhibitory neuron;Knock-out;Knockout Mice;Link;Lysine;Mediating;member;Memory;Memory impairment;Metabolic;Microcephaly;Modification;Molecular;mouse model;Mus;Mutant Strains Mice;Mutation;myelination;nerve stem cell;neural;neural circuit;Neurodevelopmental Disorder;Neurons;neurotransmission;novel therapeutic intervention;Pathogenesis;Pathogenicity;Phenotype;Play;postnatal;Process;promoter;Proteins;Reagent;Reporting;risk variant;Role;skeletal abnormality;spatiotemporal;success;Tissue-Specific Gene Expression;transcription factor;Transcriptional Regulation;transcriptome;Vorinostat

PROJECT_TITLE: Epigenetic mechanisms of histone methyltransferase ASH1L in autism spectrum disorder

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BN-P(57)]


ADMINISTERING_IC: ES

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Effects of Indoor Air Pollution;Prevention;Social Determinants of Health

ORG_CITY: DETROIT

ORG_NAME: WAYNE STATE UNIVERSITY

PHR: Project Narrative In collaboration with CLEAR’s other projects and cores, the CEC will facilitate bidirectional exchange of knowledge among CLEAR Center researchers, residents, local organizations, and other stakeholders in Detroit and the surrounding region. The CEC will advance the CLEAR mission through community engagement, outreach and education across Detroit, using a combination of traditional and innovative strategies to increase a broad understanding of the prevalence of VOCs in homes across the Detroit area and how to identify and reduce potential sources of VOCs in homes. The CEC will implement strategies to inform residents about VOCs hazards, while also providing referrals and resources to reduce VOC exposure.

PI_NAMEs: THOMPSON, THOMAS LYKE (contact)

PROJECT_TERMS: Address;Advocate;Area;arm;Assessment tool;Awareness;Benzene;Carbon;Cities;citizen science;Collaborations;Communication;Communities;community advisory board;community empowerment;community engaged approach;community engagement;Community Health Education;community organizations;community-centered;Dedications;Development;Devices;Education;Education and Outreach;Effectiveness;Environmental Hazards;Environmental Health;environmental justice;ethylbenzene;Exposure to;Feedback;Focus Groups;Future;Gases;ground water;hazard;Hazard Identification;Hazardous Substances;Health;Health Hazards;Home;Housing;Human;improved;Industrialization;Infant;innovation;Intervention;Knowledge;Leadership;Logic;Maternal Health;Measures;member;Michigan;Mission;Modeling;Neighborhoods;Newsletter;offspring;Outcome;Outcome Measure;Output;outreach;Participant;Persons;Phase;Poverty;Premature Birth;Prevalence;prevent;Prevention;Process;process improvement;Property;Public Health;Public Policy;recruit;Reporting;Research;Research Personnel;Resources;Risk;Risk Assessment;Signal Recognition Particle;Soil;Source;Superfund;Surveys;Techniques;Tetrachloroethylene;Toluene;Training;Trichloroethylene;two way texting;vapor;vapor intrusion;volatile organic compound;Volatilization;volunteer;wasting;Work;Xylene

PROJECT_TITLE: Community Engagement Core


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Social Determinants of Health

PHR: Project Narrative The Center for Leadership in Environmental Awareness and Research (CLEAR) proposes an integrated, transdisciplinary framework, rooted in advanced techniques in environmental engineering and biomedical research, to address human exposure routes and health risks from volatile organic compounds (VOCs) in urban areas. The Research Experience and Training Coordination Core (RETCC) takes a systemic approach to respond to SRP’s strategic mandates, and builds on WSU’s strategic imperatives of diversity, inclusion, and social justice. It supports holistic career development for diverse trainees through transdisciplinary, experiential leadership opportunities anchored in inclusive excellence and environmental justice principles and plays a central role in preparing the next generation of leaders in the environmental and/or biomedical sciences to address complex environmental health problems.

PI_NAMEs: PETRIELLO, MICHAEL CURTIS (contact)

PROJECT_TERMS: Active Learning;Address;Attitude;Awareness;Biomedical Research;Budgets;career;career development;Chemicals;Cities;Collaborations;Communication;Communities;community engagement;Competence;Complex;Core Facility;Country;Data Analyses;data management;data sharing;Dedications;design;Development;Development Plans;Discipline;diversity and inclusion;Educational process of instructing;Educational workshop;Environment;Environmental Engineering technology;Environmental Health;environmental health disparity;environmental justice;Equity;evidence base;experience;exposed human population;exposure route;Exposure to;Feedback;Fellowship Program;Funding;Goals;graduate student;Grant;ground water;Growth and Development function;Health;Industrialization;Institution;Internships;Knowledge;Laboratory Research;Leadership;leadership development;Mentors;Michigan;Modeling;Monitor;next generation;offspring;Outcome;Participant;peer coaching;Pilot Projects;Play;Policy Making;Postdoctoral Fellow;Premature Birth;Preparation;Process;Property;Research;research faculty;Research Project Grants;Resources;Risk;Role;Science;Scientist;Series;Signal Recognition Particle;skills;Social Justice;Soil;Student recruitment;Students;Superfund;symposium;System;Techniques;Training;training opportunity;Translating;Translational Research;Travel;Universities;urban area;urban setting;vapor intrusion;virtual;volatile organic compound;webinar;Work

PROJECT_TITLE: Research Experience & Training Coordination Core


ADMINISTERING_IC: DC

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: PROJECT NARRATIVE The proposed project will advance our understanding of the nature of developmental signals crucial for the formation and innervation of the hearing organ and inform new therapeutic strategies to promote circuit repair and regeneration for hearing restoration. Molecules identified in the inner ear likely also have general functions in nervous system development and repair, thus are potential therapeutic targets relevant in treatment of other congenital birth defects and sensory disorders.

PI_NAMEs: CLANCY, SHAYLYN  (contact)

PROGRAM_OFFICER_NAME: SCHURMAN, JACLYN REBECCA

PROJECT_TERMS: Acoustic Trauma;Adhesions;Afferent Neurons;Alleles;Apical;apical membrane;Auditory;Axon;axon guidance;base;Behavior;Binding;Biological Assay;Brain;Cell Adhesion;Cell Adhesion Molecules;cell behavior;Cell-Cell Adhesion;Characteristics;Chimeric Proteins;Cochlea;Cochlear nucleus;Coculture Techniques;conditional knockout;Congenital Abnormality;CRISPR/Cas technology;Cytoskeleton;Data;Development;Developmental Process;Disease;Dissociation;Embryo;emx2 protein;Epithelium;experimental study;Fc domain;Foundations;Genes;Goals;Guanosine Triphosphate;Guanosine Triphosphate Phosphohydrolases;Hair;Hair Cells;Hearing;hearing impairment;hearing restoration;hindbrain;Immunoglobulins;Immunohistochemistry;inner ear development;Inner Hair Cells;insight;Intercellular Junctions;Knock-out;Knockout Mice;Knowledge;Label;Labyrinth;Ligands;loss of function;Mammals;Mediating;member;Membrane;Molecular;Morphogenesis;Morphology;Mus;mutant;Natural regeneration;Nature;nectin;nerve supply;Nervous System;nervous system development;Neurons;new therapeutic target;Noise;novel;novel therapeutic intervention;noxacusis;Organ;Organ of Corti;Outer Hair Cells;Pain;Pathway interactions;Pattern;Peripheral;Pillar Cell;planar cell polarity;Play;polarized cell;Property;Proteins;receptor;Regulation;repaired;Reporter;rho GTP-Binding Proteins;Role;Sensory;Sensory Disorders;Signal Transduction;sound;spiral ganglion;Stereotyping;Supporting Cell;Testing;therapeutic target;tissue fixing;Tissue imaging;Tissues;Transgenic Organisms;transmission process;ubiquitin-protein ligase;Work

PROJECT_TITLE: Elucidating the Role of Epithelial PCP signaling in SGN Axon Guidance in the Cochlea

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Cancer;Digestive Diseases;Immunization;Immunotherapy;Orphan Drug;Pancreatic Cancer;Precision Medicine;Prevention;Rare Diseases;Vaccine Related

ORG_CITY: IRVINE

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

ORG_STATE: CA

PHR: PROJECT NARRATIVE Pancreatic ductal adenocarcinoma (PDAC) has a high risk of recurrence and mortality even after removal and subsequent chemoradiotherapy. We will perform the first study of preventive dendritic cell (DC) vaccination combined with chemotherapy to prevent PDAC recurrence while simultaneously using imaging of migrating magnetically labeled DC vaccine to predict vaccine efficacy.

PI_NAMEs: YAGHMAI, VAHID ;ZHANG, ZHUOLI  (contact)

PROGRAM_OFFICER_NAME: LIN, CHARLES

PROJECT_TERMS: Abdomen;Adjuvant;Affect;anti-tumor immune response;Biodistribution;Body System;Cancer Etiology;cancer recurrence;cancer therapy;Cells;chemoradiation;chemotherapy;Chemotherapy and/or radiation;Clinic;Clinical;clinical application;clinical efficacy;clinical translation;Colorectal Neoplasms;Combined Modality Therapy;curative treatments;dendritic cell vaccination;Dendritic Cell Vaccine;Dendritic Cells;Dose;early detection biomarkers;Excision;ferumoxytol;Funding;gemcitabine;Genetic Heterogeneity;Genetically Engineered Mouse;Guidelines;Heparin;high risk;Homing;Image;imaging biomarker;Immunotherapy;Implant;implantation;improved;in vivo;Individual;individual patient;intraperitoneal;Intraperitoneal Injections;Kidney Neoplasms;KPC model;Label;Liver neoplasms;lymph nodes;Lymphoid Tissue;Magnetic Resonance Imaging;Magnetism;Malignant neoplasm of pancreas;Maps;Measurement;Methods;migration;Monitor;mortality;mouse model;Mus;nanocomplexes;National Comprehensive Cancer Network;Neoplasm Metastasis;neoplastic cell;novel;novel strategies;Operative Surgical Procedures;Outcome;Paclitaxel;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma model;pancreatic neoplasm;Patients;Peer Review;Postoperative Period;predicting response;Prediction of Response to Therapy;predictive marker;Predisposition;prevent;Preventive;Primary Neoplasm;Protamines;Publications;Recommendation;Recurrence;Recurrent tumor;relapse prevention;response;Role;Route;Solid;Stomach Neoplasms;Subcutaneous Injections;success;Tail;Techniques;Testing;Therapeutic;Time;Tissues;Titrations;Transgenic Organisms;Translating;translational model;Treatment Efficacy;treatment response;treatment strategy;tumor;tumor growth;United States National Institutes of Health;Uterine Neoplasms;vaccination strategy;vaccine efficacy;vaccine response;Vaccine Therapy;Vaccines;Veins;Work

PROJECT_TITLE: Developing MRI-Guided Preventive Dendritic Cell Vaccination Strategy to Avoid Post-surgical Pancreatic Cancer Recurrence and Metastasis

STUDY_SECTION: IGIS

STUDY_SECTION_NAME: Imaging Guided Interventions and Surgery Study Section[IGIS]


NIH_SPENDING_CATS: Bioengineering;Biotechnology

PHR: PROJECT NARRATIVE: Chemical Analysis Core (CAC) The CENTER FOR LEADERSHIP IN ENVIRONMENTAL AWARENESS AND RESEARCH (CLEAR) has built an integrated, transdisciplinary framework, rooted in advanced techniques in environmental engineering and biomedical research, to address human exposures to volatile organic compounds (VOCs) and health risks in urban areas. The Chemical Analysis Core participates in CLEAR research projects and Community Engagement by providing analytical knowledge, training and services as well as guidance, and new technologies to measure low levels of VOCs as well as other markers of VOC exposures, which will enable CLEAR researchers to determine the degree of exposure and assess its impact on human health.

PI_NAMEs: WESTRICK, JUDY A (contact)

PROJECT_TERMS: Address;adduct;Air;analytical method;Animal Model;Awareness;Biological;Biological Assay;biomarker discovery;biomarker identification;Biomedical Research;Chemicals;Chronic;Cities;cohort;community engagement;cost;cytokine;Data Science;Dedications;design;Detection;Discipline;Disease;Dose;Educational workshop;Emerging Technologies;Ensure;Environmental Engineering technology;Environmental Exposure;Environmental Health;Evaluation;Experimental Designs;experimental study;exposed human population;Exposure to;Geographic Locations;graduate student;ground water;Health;high throughput analysis;Human;Immunoassay;Industrialization;Inflammation;Inflammation Mediators;Informatics;innovation;instrument;instrumentation;Knowledge;Laboratory Personnel;Laboratory Research;Leadership;Mass Spectrum Analysis;Measurement;Measures;Methods;Microfluidics;Mission;Molecular;Monitor;monitoring device;multidisciplinary;new technology;next generation;novel;novel strategies;offspring;Outcome;Pathway interactions;Peptides;Persons;Physiological;pollutant;population based;Post-Translational Protein Processing;Postdoctoral Fellow;Premature Birth;Preparation;Property;Protein Analysis;Proteins;Proteome;Proteomics;Reproducibility;Research;Research Personnel;Research Project Grants;residence;Resources;response;Risk;Sampling;Science;sensor;Services;small molecule;Soil;Superfund;System;Techniques;Technology;Testing;Time;Toxic effect;Training;Uncertainty;urban area;vapor intrusion;volatile organic compound;Volatilization;Work

PROJECT_TITLE: Chemical Analysis Core


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: PHILADELPHIA

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative This proposal aims to extend the cellular, synaptic and circuit level understanding of circuit state modulation from studies of an individual hormone action on a single circuit state to the impact of a complete hormonal environment from a particular behavioral state on several different circuit states from the same defined connectome. We aim to address this issue by studying the fully-defined motor circuits in the isolated crab (Cancer borealis) stomatogastric ganglion, using a multi-disciplinary approach that combines electrophysiological manipulations of identified circuit neurons with mass spectroscopic identification of individual hormones and their biologically relevant concentrations. Insofar as the neural circuits in many, and perhaps all, animals are configured via neuromodulation into different circuit states, and no previous study appears to have addressed this issue at the level proposed herein, a positive outcome from the proposed experiments will contribute to fundamental knowledge about the nature and behavior of living systems.

PI_NAMEs: NUSBAUM, MICHAEL P (contact)

PROGRAM_OFFICER_NAME: CHEN, DAOFEN

PROJECT_TITLE: Hormonal Tuning of Specific Circuit States from a Well-Defined Connectome

STUDY_SECTION: SMN

STUDY_SECTION_NAME: Sensory-Motor Neuroscience Study Section[SMN]


ADMINISTERING_IC: DA

ED_INST_TYPE: UNIVERSITY-WIDE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Methamphetamine;Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Prevention;Rural Health;Social Determinants of Health;Stimulant Use and Misuse;Substance Misuse;Substance Misuse Prevention

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: NARRATIVE: Substance use, especially in young and middle adulthood, is a major public health problem in the United States, costing more than 100,000 lives and $440 billion annually. This project aims to understand the role of local labor market structure in substance use behaviors and its socio-physical-behavioral health mechanisms, to develop agent-based models to make substance use/use disorder/overdose projections for Ohio through 2030, and to conduct policy experiments. Findings will inform policy interventions to prevent substance use problems, which is especially relevant for areas experiencing economic contractions or employment shocks following a pandemic.

PI_NAMEs: OH, SEHUN  (contact)

PROGRAM_OFFICER_NAME: JENKINS, RICHARD A

PROJECT_TERMS: Acceleration;Address;Adult;Affect;Age;Alcohols;Analgesics;Appalachian Region;Area;Award;Behavior;behavioral health;career development;Categories;Characteristics;Cocaine;Collaborations;Communities;contextual factors;cost;County;Crime;Data;Death Rate;design;Development;Development Plans;disability;disability risk;Disease;Disparate;Doctor of Philosophy;Drug Prescriptions;Drug usage;Economics;Employment;Employment Opportunities;Epidemic;Epidemiology;Etiology;experience;experimental study;Family;Feeling hopeless;Fentanyl;Frustration;Future;geographic difference;Geography;Goals;healing;Health;Heroin;Illicit Drugs;improved;Individual;Industry;Injury;Instruction;Intervention;Knowledge;Laws;Light;Link;local economy;Manuals;manufacture;Marijuana;marijuana legalization;Marketing;Measures;Mediator;Mental disorders;Mentored Research Scientist Development Award;Mentors;Methamphetamine;methamphetamine use;Methodology;Methods;Modeling;models and simulation;Monitor;mortality;National Longitudinal Survey of Youth;Occupational;Occupations;Ohio;Opioid;opioid use;Outcome;Overdose;overdose death;overdose risk;pandemic disease;Pattern;Personal Satisfaction;Pharmaceutical Preparations;physical conditioning;pill;Play;Policies;Policy Developments;polysubstance use;Population;Positioning Attribute;prescription monitoring program;Prevention;Prevention Research;Prevention strategy;Preventive;Probability;Public Health;Public Policy;Reporting;Research;Research Activity;Research Personnel;research study;Resources;Risk;Role;rural counties;Science;Series;Services;Shapes;Shock;skills;Social Policies;Social Work;socioeconomics;statistics;Structure;Substance abuse problem;substance use;Substance Use Disorder;substance use prevention;Supervision;Surveys;synthetic opioid;System;Testing;Time;Training;Training Activity;Training Programs;Translational Research;trend;United States;Urban Community;Violence;Wages;Work;Workplace

PROJECT_TITLE: Local labor market contexts and substance use in young and middle adulthood: Using agent-based modeling to guide substance use prevention strategies

STUDY_SECTION: SSPA

STUDY_SECTION_NAME: Social Sciences and Population Studies A Study Section[SSPA]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Digestive Diseases;Genetics;Infectious Diseases;Lung;Microbiome;Pneumonia;Pneumonia and Influenza

ORG_CITY: WINSTON-SALEM

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

ORG_STATE: NC

PHR: Public Health Relevance. Klebsiella pneumoniae (Kpn) is a leading cause of hospital-acquired infections. Epidemiological studies show that the gastrointestinal is the main reservoir for Kpn, through which it can cause disease in the colonized host or transmit to another host. This project aims to define the factors that allow Kpn to establish itself in the gut.

PI_NAMEs: ZAFAR, MUHAMMAD AMMAR (contact)

PROGRAM_OFFICER_NAME: ERNST, NANCY L

PROJECT_TERMS: Affect;Animal Model;Antibiotic Resistance;Arginine;Biological;Biological Assay;burden of illness;Bypass;Catabolism;Cell membrane;Cellular Membrane;colonization resistance;combat;Data;Development;diarrheal disease;Diet;digital;Disease;drug resistant pathogen;enteric pathogen;epidemiology study;Ethanolamines;Failure;Feces;fitness;gastrointestinal;Gastrointestinal tract structure;gene product;Genes;Genetic Screening;genomic locus;Gnotobiotic;Gram-Negative Bacteria;gut colonization;gut microbiome;gut microbiota;host colonization;Immune system;Immunocompetent;In Vitro;in vivo;Infection;Inflammatory;insight;Investigation;Kinetics;Klebsiella pneumoniae;Knock-out;Knowledge;Libraries;Link;member;Metabolic Pathway;Metabolism;metabolomics;metagenome;metagenomic sequencing;Metagenomics;microbiome;microbiome components;microbiota;microorganism;Modeling;Molecular;mouse model;Mucous Membrane;Multi-Drug Resistance;Mus;mutant;Nosocomial Infections;novel;Nutrient;Nutritional;Operon;Oral;Oropharyngeal;Outcome;pathogen;pathogenic bacteria;Pathway interactions;Patients;Prevention;Process;public health relevance;Regulation;Role;Route;Site;Source;success;System;transmission process;uptake

PROJECT_TITLE: Mechanisms of Klebsiella pneumoniae gastrointestinal colonization

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IIDB-K(90)]


NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Depression;Mental Health;Mental Illness;Neurosciences;Post-Traumatic Stress Disorder (PTSD)

ORG_CITY: NEW HAVEN

ORG_DEPT: PSYCHIATRY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Narrative Exposure to stress can induce active coping behaviors, but is also a precipitating factor for human anxiety, depression and post-traumatic stress disorder. Stress increases release of the neurotransmitter acetylcholine (ACh) and we have found that levels of ACh are elevated throughout the human brain when patients are currently depressed. We propose to study stress- induced ACh release, how this becomes dysregulated in response to prolonged stress, and whether it alters coping behaviors, so we can understand brain circuits that are dysfunctional in patients with stress disorders and find new ways to treat those who do not respond to existing treatments.

PI_NAMEs: MINEUR, YANN SEBASTIEN;PICCIOTTO, MARINA R (contact)

PROGRAM_OFFICER_NAME: HUPALO, SOFIYA

PROJECT_TERMS: Acetylcholine;Acute;acute stress;Adaptive Behaviors;Amygdaloid structure;Animals;antagonist;anti-depressive agents;Anxiety;Anxiety Disorders;Area;Attention;Autonomic nervous system;Aversive Stimulus;awake;Back;basal forebrain;basal forebrain cholinergic neurons;Behavior;Behavioral;behavioral plasticity;behavioral response;Binding;biological adaptation to stress;Brain;Brain region;cholinergic;cholinergic neuron;Cholinergic Receptors;Chronic stress;Clinical Research;Cognitive;cognitive control;Collection;Complex;coping;Coping Behavior;Depressed mood;Desire for food;Development;Disease;Dorsal;Emotional;Energy Metabolism;Environment;epidemiology study;Equilibrium;Ethology;experience;Exposure to;flexibility;Food;Freezing;Functional disorder;genetic approach;Hippocampus;Human;human imaging;Hyperactivity;hypothalamic-pituitary-adrenal axis;imaging study;Immobilization;Impaired cognition;Individual;Learning;Measures;Mediating;Mental Depression;mesolimbic system;Modeling;monoamine;Mus;Neuromodulator;Neurons;neurotransmission;neurotransmitter release;Neurotransmitters;novel;Partner in relationship;Pathway interactions;Patients;Play;Post-Traumatic Stress Disorders;Precipitating Factors;Predisposition;Prefrontal Cortex;prevent;receptor;resilience;response;Rewards;Role;Shelter facility;Signal Transduction;social;Stimulus;Stress;stress disorder;Stressful Event;stressor;Structure;Symptoms;Synapses;System;Testing;therapeutic development;Treatment Efficacy

PROJECT_TITLE: Cholinergic Contribution to Circuits Guiding Behavioral Responses to Stressors

STUDY_SECTION: MCNP

STUDY_SECTION_NAME:
Molecular and Cellular Neuropharmacology Study Section
[MCNP]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Immunotherapy;Infectious Diseases;Lung;Orphan Drug;Prevention;Rare Diseases;Tuberculosis;Tuberculosis Vaccine;Vaccine Related

ORG_CITY: SAN FRANCISCO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative TB remains a global health threat with 9.9 million new TB cases globally in 2020. TB vaccine endeavors have been largely unsuccessful in preventing infection, but the recent clinical trial of M72-AS01E demonstrated ~50% efficacy as a Prevention of Disease (POD) vaccine. This project will study a vaccine targeting unique antigens in Mycobacterium tuberculosis that promotes distinct T cell responses during infection and modulates immunopathology, to inform development of improved POD vaccines for TB.

PI_NAMEs: HOWARD, ZACHARY  (contact)

PROGRAM_OFFICER_NAME: MENDEZ, SUSANA

PROJECT_TERMS: Adoptive Transfer;Animal Model;Antigen Targeting;antigen-specific T cells;Antigenic Variation;Antigens;Bacteria;BCG Live;candidate identification;CD4 Positive T Lymphocytes;Cessation of life;Clinical;Clinical Trials;COVID-19;Data;Development;Disease;disorder prevention;DNA Vaccines;drug resistance development;effector T cell;Epidemiology;Exhibits;Flow Cytometry;Genes;Genome;genome analysis;global health;Goals;Human;human model;Immune;Immune Evasion;Immune response;Immunofluorescence Microscopy;Immunohistochemistry;immunopathology;immunoregulation;improved;Individual;Infection;Infection prevention;Inflammation;Inflammatory;Investigation;Laboratories;Licensing;Lung;Lymphoid;Mediating;Mediator;Mus;Mutation;Mycobacterium tuberculosis;Mycobacterium tuberculosis antigens;Myelogenous;novel;pathogen;Peptide/MHC Complex;Phenotype;Phylogenetic Analysis;Population;pressure;prevent;Pulmonary Inflammation;Pulmonary Tuberculosis;response;Role;single-cell RNA sequencing;Sorting;T cell receptor repertoire sequencing;T cell response;T-Lymphocyte;T-Lymphocyte Epitopes;T-Lymphocyte Subsets;Testing;transmission process;Tuberculosis;Tuberculosis Vaccines;Vaccinated;Vaccination;Vaccine Antigen;vaccine development;vaccine response;Vaccines;Variant;Work

PROJECT_TITLE: Mechanistic investigation of differential T cell responses to distinct Mycobacterium tuberculosis antigens


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Data Science;Heart Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention

PHR: A new NIH-funded study, HeartShare, aims to gather a wide range of multi-omics data to better understand the etiology of heart failure with preserved ejection fraction (HFpEF) to guide targeted therapeutic developments. However, such rich data modalities are costly and not easy to gather from patients receiving currently available standard of care. Our ancillary study aims to utilize low cost and accessible electrocardiogram data via artificial intelligence to predict and subtype HFpEF.

PI_NAMEs: AKBILGIC, OGUZ  (contact)

PROGRAM_OFFICER_NAME: TINSLEY, EMILY

PROJECT_TERMS: Acute;adjudication;Adult;Ancillary Study;Artificial Intelligence;artificial intelligence method;artificial intelligence model;burden of illness;Cardiology;Cardiovascular Diseases;Cardiovascular system;Cause of Death;Chicago;Chronic;Classification;Clinical Data;cohort;cost;Data;data modalities;Data Set;Death Rate;deep learning;deep learning model;Detection;Diagnosis;diagnostic criteria;Early Diagnosis;EFRAC;Electrocardiogram;electronic health data;Electronic Health Record;Enrollment;Epidemiology;Etiology;Funding;Goals;hands-on learning;Health Sciences;Healthcare Systems;Heart failure;heart failure with reduced ejection fraction;improved;Individual;Intervention;Knowledge;learning strategy;Left Ventricular Ejection Fraction;Machine Learning;Methods;Modality;model building;Modeling;Modification;Morbidity - disease rate;mortality;Multiomic Data;multiple omics;National Heart, Lung, and Blood Institute;novel;older adult;Older Population;Participant;patient population;Patients;Phenotype;predictive modeling;preservation;Preventive;Prognosis;Quality of life;repository;Research;Risk;risk prediction;risk prediction model;Risk Reduction;screening;Site;standard of care;Standardization;Syndrome;targeted treatment;Tennessee;Testing;therapeutic development;tool;Training;transfer learning;Treatment Failure;treatment optimization;United States;United States National Institutes of Health;Universities;Validation;Women's prevalence;Work

PROJECT_TITLE: ECG-AI Based Prediction and Phenotyping of Heart Failure with Preserved Ejection Fraction

STUDY_SECTION: CDMA

STUDY_SECTION_NAME: Clinical Data Management and Analysis Study Section[CDMA]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Genetics;Infectious Diseases

ORG_CITY: KNOXVILLE

ORG_NAME: UNIVERSITY OF TENNESSEE KNOXVILLE

ORG_STATE: TN

PHR: Campylobacter spp. are the leading cause of bacterial-derived gastrointestinal infection in the world with significant impacts on human health in both developed and developing countries. This prevalence is primarily due to the ability of these bacteria to reside in the gastrointestinal tracts of various animals and transmit to humans where they colonize the colon and cause inflammation. This project will work to understand how a novel regulator in C. jejuni controls nutrient acquisition through sensing an uncommon intracellular signal and subsequently upregulating a system that can transport and metabolize a host-derived molecule to obtain the nutrient it contains.

PI_NAMEs: JOHNSON, JEREMIAH  (contact)

PROGRAM_OFFICER_NAME: BAQAR, SHAHIDA

PROJECT_TERMS: Affect;Anabolism;Animal Model;Animals;Bacteria;Binding;Biological Assay;Birds;Campylobacter;Campylobacter infection;Campylobacter jejuni;ChIP-seq;Chronic Disease;Citric Acid Cycle;Colon;Communication;Consumption;contaminated water;Cytoplasm;Developing Countries;Diarrhea;Disease;DNA;Domestic Fowls;Environment;Enzymes;Exhibits;Ferrets;follow-up;Food;Food Contamination;Future;Gastroenteritis;gastrointestinal;gastrointestinal infection;Gastrointestinal tract structure;Gene Expression;Gene Expression Regulation;Genes;Genetic Determinism;Growth;Health;Heme;heme a;Heme Group;Hemoglobin;Homeostasis;host colonization;host microbiota;Human;Immune system;in vivo;Infection;Inflammation;Ingestion;insight;Intestines;Invaded;Iron;Knowledge;Ligand Binding;Measures;Metabolism;Metals;Methionine;Methods;Modeling;mutant;Mutation;novel;Nutrient;Nutrient availability;Nutritional;Operon;Organism;pathogen;Predisposition;Prevalence;Process;Production;Research;response;Role;Signal Transduction;Site;Source;System;Time;transcriptomics;transmission process;undercooked;Work

PROJECT_TITLE: Integration of nutrient availability, TCA cycle activity, and colonization factor expression in Campylobacter jejuni

STUDY_SECTION: BACP

STUDY_SECTION_NAME: Bacterial Pathogenesis Study Section[BACP]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Digestive Diseases;Genetics;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: BOSTON

ORG_NAME: DANA-FARBER CANCER INST

ORG_STATE: MA

PHR: Project Narrative: Continuous renewal of the cells that line our digestive tract is essential for health and depends on signals from adjacent ‘mesenchyme.’ Distinct cell populations within the ‘mesenchyme’ serve crucial supportive functions, but their origins and organizational principles remain unknown. Our studies aim to elucidate how discrete cells assemble into a supportive tissue in fetal and early post- natal life and will reveal strategies to prevent or better treat inflammatory bowel disorders.

PI_NAMEs: SHIVDASANI, RAMESH A (contact)

PROGRAM_OFFICER_NAME: GREENWEL, PATRICIA

PROJECT_TERMS: Abbreviations;Acceleration;Actins;Address;Adult;Anatomy;base;Basic Science;Biological Assay;Blood capillaries;Blood Vessels;BMP6 gene;Bone Morphogenetic Proteins;CD34 gene;CD81 gene;cell assembly;Cell Differentiation Induction;Cell Differentiation process;Cell Line;Cell Maturation;Cell Nucleus;Cell Proliferation;cell type;Cells;Censuses;Chromatin;cofactor;Collection;Colon;Colorectal Cancer;Complement;Consensus;Data;design;Development;Developmental Biology;developmental plasticity;Digestive Physiology;Dimensions;Disease;Elements;Embryo;Endoderm;Endothelial Cells;Enterobacteria phage P1 Cre recombinase;Epidermal Growth Factor;Epithelial Cells;Epithelium;Erinaceidae;Estrogen Receptors;experimental study;fetal;fetus cell culture;Fibroblasts;Foundations;FOXL1 gene;Funding;Future;Gastrointestinal tract structure;Genetic;Genetic Transcription;Growth;Health;Human;improved;Inflammatory Bowel Diseases;inhibitor;injured;Injury;insight;Interleukin-6;intestinal crypt;intestinal injury;Intestines;Investigation;Knowledge;Laboratories;LGR5 gene;Life;Ligands;Maps;Mesenchymal;Mesenchyme;Mesoderm;Mitotic;Modeling;Modernization;Molecular;Motivation;Mus;Muscularis Mucosa;Myofibroblast;novel;PDGFRA gene;Pericytes;Population;postnatal;prevent;Process;progenitor;Recombinants;reconstitution;Regulatory Element;repaired;Reporter;Reporting;Rest;restraint;segregation;self organization;self-renewal;SHH gene;Signal Induction;Signal Transduction;Signaling Protein;Small Intestines;Smooth Muscle;Smooth Muscle Myocytes;Solid;Source;Specific qualifier value;stem cell niche;stem cells;Stereotyping;Stromal Cells;Submucosa;success;Tamoxifen;Testing;tissue repair;Tissues;transcription factor;transcriptome sequencing;Transposase;vasculogenesis;Villus;Work;XCL1 gene

PROJECT_TITLE: Development and vascularity of intestinal mesenchyme

STUDY_SECTION: DNPD

STUDY_SECTION_NAME: Digestive and Nutrient Physiology and Diseases Study Section [DNPD]


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dental, Oral, and Craniofacial Disease;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Orphan Drug;Racial and Ethnic Minority Health Research;Radiation Oncology;Rare Diseases;Social Determinants of Health

ORG_CITY: CHARLESTON

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: PROJECT NARRATIVE For patients with head and neck cancer, delays starting adjuvant radiation therapy are common, disproportionately burden racial minorities, and contribute to poor survival and racial disparities in mortality. However, effective therapies to improve the delivery of timely, equitable, guideline-adherent adjuvant radiation therapy are lacking. We have developed a navigation-based multilevel intervention to enhance care coordination, communication, and key cancer care delivery processes that could provide the first effective treatment in this population, thereby improving survival, decreasing racial disparities in outcomes, and developing new standards of clinical care.

PI_NAMEs: GRABOYES, EVAN MICHAEL (contact)

PROGRAM_OFFICER_NAME: WEAVER, SALLIE JAYNE

PROJECT_TERMS: Address;Adjuvant Radiotherapy;Adjuvant Therapy;Administrator;Affect;arm;Behavior;black patient;Breast;cancer care;Cancer Center;cancer therapy;cancer type;care coordination;care delivery;Caring;Cessation of life;chemotherapy;Clinical;clinical care;clinical practice;Cluster randomized trial;Colon;Communication;Data;Disease;Disparity;effective therapy;Effectiveness;effectiveness evaluation;effectiveness testing;effectiveness/implementation study;effectiveness/implementation trial;Equity;evidence base;Guidelines;Head and Neck Cancer;Head and Neck Surgery;Health behavior;Hybrids;Immunotherapy;implementation outcomes;improved;Intervention;Interview;Knowledge;Lung;Malignant Neoplasms;Methods;mortality disparity;mortality risk;Multicenter Trials;multidisciplinary;National Comprehensive Cancer Network;Operative Surgical Procedures;Outcome;Pathway interactions;Patients;Performance;Population;Postoperative Period;Process;Provider;Publishing;racial disparity;racial minority;Radiation;Radiation therapy;Randomized;randomized trial;Recommendation;Referral and Consultation;Site;Social support;standard of care;Structure;Surgeon;survival disparity;System;Translating;treatment as usual;Work

PROJECT_TITLE: A Type I Hybrid Effectiveness-Implementation Trial to Evaluate a Navigation-Based Multilevel Intervention to Decrease Delays Starting Adjuvant Therapy Among Patients with Head and Neck Cancer

STUDY_SECTION: HSQE

STUDY_SECTION_NAME: Health Services: Quality and Effectiveness Study Section[HSQE]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Rare Diseases;Vector-Borne Diseases

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative The goal of this application is to define how LDLRAD3, a recently identified novel entry receptor, engages Venezuelan equine encephalitis virus (VEEV) to promote cell entry, infection, and disease. An enhanced understanding of structure-function relationships between LDLRAD3 and VEEV may facilitate the development of medical countermeasures against this emerging, pathogenic virus.

PI_NAMEs: DIAMOND, MICHAEL S (contact);FREMONT, DAVED H.

PROGRAM_OFFICER_NAME: DUPUY, LESLEY CONRAD

PROJECT_TERMS: Acute;Acute Disease;acute infection;Aerosols;Africa;Alpha Virus;Alphavirus Infections;Americas;Animals;Anti-viral Agents;Antibodies;Binding;Binding Sites;Biochemical;Biological Assay;biological development;Biology;Biophysics;Cell membrane;Cell surface;cell type;Cells;Chikungunya virus;Chronic;Confocal Microscopy;CRISPR/Cas technology;Cryoelectron Microscopy;Culicidae;Data;defined contribution;Development;Diamond;Disease;Disease Outbreaks;Disease Outcome;Dissection;Ectopic Expression;emerging pathogen;env Gene Products;Epidemic;Epitopes;epizootic;Equus caballus;experimental study;Family;Fc Receptor;Fever;Future;Genes;Genetic;genetic analysis;Genetic study;genome-wide;Glycoproteins;Goals;Human;Immunoelectron Microscopy;in vivo;Infection;innovation;insight;Integration Host Factors;Knockout Mice;Label;Laboratories;Libraries;Licensing;Life Cycle Stages;Mediating;Medical;medical countermeasure;member;Membrane;Molecular Conformation;Morphogenesis;mouse model;Mus;Mutagenesis;mutant;N-terminal;Nature;Neurons;novel;novel strategies;Oceania;Pathogenesis;pathogenic virus;Pathogenicity;Pathway interactions;Penetration;Polyarthritides;prevent;Prevention;Proteins;Reagent;receptor;receptor internalization;Recombinants;Resolution;RNA Viruses;Role;Route;scavenger receptor;small molecule;Structure;Structure-Activity Relationship;Therapeutic;tissue tropism;Tissues;Togaviridae;Translating;transmission process;Tropism;Universities;Vaccines;Venezuelan Equine Encephalitis Virus;Vertebrates;Vesicular stomatitis Indiana virus;Video Microscopy;Viral;Viral Pathogenesis;Virion;virology;Virus;Virus Diseases;virus testing;Washington;Western Equine Encephalitis Virus;X-Ray Crystallography

PROJECT_TITLE: LDLRAD3 Receptor Interaction with Venezuelan Equine Encephalitis Virus


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;Immunization;Infectious Diseases;Lung;Rare Diseases;Tuberculosis;Vaccine Related

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), has a complex cell wall which contains many unique lipids, making them attractive targets for immune recognition in host defense. This proposal aims to use a novel humanized transgenic mouse model to study the regulation and function of a conserved mycobacterial lipid antigen-specific T cell population during Mtb infection. Findings from our studies will provide foundation for future studies of the clinical relevance of this T cell population in human TB.

PI_NAMEs: WANG, CHYUNG-RU  (contact)

PROGRAM_OFFICER_NAME: VAZQUEZ-MALDONADO, NANCY

PROJECT_TERMS: Activities of Daily Living;Address;Adoptive Transfer;Affect;Affinity;alpha-beta T-Cell Receptor;Antigen Presentation;Antigen-Presenting Cells;antigen-specific T cells;Antigens;Antimycobacterial Agents;Attenuated;Avidity;Bacille Calmette-Guerin vaccination;Binding;Biological Markers;Bone Marrow;CD8B1 gene;Cell Compartmentation;Cell Line;Cell Lineage;Cell Separation;Cell Wall;Chimera organism;clinically relevant;Complex;cytokine;cytotoxic;Data;design;Development;Disease;Drug or chemical Tissue Distribution;engineered T cells;Exhibits;Foundations;Frequencies;Future;Gene Expression Profile;Gene Expression Profiling;Generations;Genes;Genetic Polymorphism;Germ Lines;glucose mycolate;Glycolipids;Growth;Homologous Gene;Host Defense;Human;Immune response;Immune Targeting;Immunity;immunogenic;in vivo;Individual;interest;Interferon Type II;Kinetics;Lipids;Liquid substance;Lung;Maintenance;Mediating;Memory;Modeling;Molecular;mouse model;Mus;mycobacterial;Mycobacterium Infections;Mycobacterium tuberculosis;Mycobacterium tuberculosis H37Rv;Mycolic Acid;Nature;nonhuman primate;novel;Pathway interactions;Patients;Peripheral;Phenotype;Physiologic pulse;Play;Population;promoter;Property;protective effect;pulmonary granuloma;receptor;receptor expression;recruit;Regulation;response;Role;Sorting;Specificity;T cell response;T memory cell;T-Cell Receptor;T-Lymphocyte;T-Lymphocyte Subsets;Testing;Tissues;TNF gene;transcription factor;transcriptome sequencing;Transgenic Mice;Transgenic Organisms;Tuberculosis;Tuberculosis Vaccines;unvaccinated;Vaccinated;Vaccination;vaccine development;Vaccines;Virulent;ZNF145 gene

PROJECT_TITLE: A new mouse model to study the function of CD1b-restricted germline encoded, mycolyl lipid-reactive (GEM) T cells

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences

ORG_CITY: Los Angeles

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Project narrative/Relevance to public health statement The NIA/AA for Institute on Methods and Protocols for Advancement of Clinical Trials in ADRD (NIA/AA IMPACT-AD) Course is a 4.5-day multidisciplinary clinical trial training course providing focused instruction on the design, conduct and analysis of ADRD clinical trials, ranging from mechanistic studies to large, community-based interventions. Multidisciplinary training that combines traditional clinical trials training with specialized skills in statistics, study recruitment, study organization, neuropsychology, ethics and informatics will accelerate the establishment of a new, diverse and well-trained cadre of investigators to lead the development of therapies for ADRD, a key priority for improving public health.

PI_NAMEs: GRILL, JOSHUA ;RAMAN, REMA  (contact)

PROGRAM_OFFICER_NAME: MCLINDEN, KRISTINA

PROJECT_TERMS: Acceleration;Achievement;Active Learning;Address;aging population;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease therapy;Area;Biological Markers;Biometry;Caliber;career;Caring;Characteristics;Clinical;clinical care;Clinical Investigator;Clinical Trials;cohort;Collection;Communication;community intervention;design;Development;Diagnosis;Disabled Persons;disadvantaged background;Disparity population;Education;Elements;Enrollment;Ensure;Ethics;Ethnic Origin;Ethnic Population;Evaluation;Evidence Based Medicine;Evolution;experience;Faculty;Funding;Future;Gender;Generations;Geriatrics;Goals;Grant;Historically Black Colleges and Universities;improved;Individual;Informatics;Infrastructure;innovation;Instruction;Interdisciplinary Study;Knowledge;Lead;Learning;Longterm Follow-up;Measures;Medical;Medical Research;medical specialist;medical specialties;Mentors;Mentorship;Methodology;Methods;Minority;Mission;Modernization;Monitor;multidisciplinary;multimodal learning;multimodality;National Institute on Aging;Neuropsychology;neuropsychopharmacology;next generation;novel;Outcome Study;outreach;Participant;Persons;Professional Organizations;programs;Protocols documentation;Public Health;Qualifying;Race;racial population;recruit;Request for Proposals;Research;Research Methodology;Research Personnel;Resources;satisfaction;Science;Scientist;skills;sociodemographics;Sorting;statistics;Structure;success;Swelling;symposium;therapy development;Training;Training Programs;trial design;United States National Institutes of Health;Woman

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Behavior and Social Science of Aging Study Section[NIA-S]


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Clinical Research;Congenital Structural Anomalies;Epilepsy;Genetics;Intellectual and Developmental Disabilities (IDD);Neurodegenerative;Neurosciences;Orphan Drug;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Tuberous Sclerosis

ORG_CITY: ANN ARBOR

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: PROJECT NARRATIVE mTOR pathway hyperactivity is a major cause of brain malformations and epilepsy, which results in morbidity, mortality, and disability, and currently available medications are unable to cure the underlying disease process and fail to control seizures in one out of three patients. Using a 3-D human neural cell culture model, the proposed project studies how hyperactivity of the mechanistic target of rapamycin (mTOR) pathway related to STRADA mutations causes cortical malformation and epilepsy. Understanding these mechanisms should help identify therapeutic targets to halt or reverse the development of epilepsy.

PI_NAMEs: DANG, LOUIS TUONG CHINH (contact)

PROGRAM_OFFICER_NAME: UMANAH, GEORGE KWABENA ESSIEN

PROJECT_TERMS: 3-Dimensional;Affect;analog;Antiepileptogenic;autism spectrum disorder;Biological Assay;Brain;brain abnormalities;brain malformation;Calcium;Cell Culture Techniques;cell fate specification;Cell Therapy;cell type;Cells;Cerebrum;Child;Complex;Cortical Dysplasia;Cortical Malformation;Data;Development;disability;Disease;Dorsal;Effectiveness;Electrophysiology (science);Epilepsy;Epileptogenesis;Etiology;excitatory neuron;Feedback;FRAP1 gene;gene-targeted therapy;Genes;Genetic;Genetic study;glial cell development;Goals;Human;Hyperactivity;Image;Immunohistochemistry;Impaired cognition;Impairment;in vitro Model;Individual;induced pluripotent stem cell;inhibitory neuron;innovation;insight;Intellectual functioning disability;Interneurons;Knowledge;loss of function;loss of function mutation;malformation;Measures;Megalencephaly;migration;Modeling;Morbidity - disease rate;Morphology;mortality;mTORopathies;multi-electrode arrays;mutant;Mutation;neural;neurodevelopment;neurogenesis;Neuroglia;Neuronal Differentiation;Neurons;novel;novel therapeutics;Organoids;Outcome;Pathogenesis;Pathogenicity;Pathway interactions;Patients;Pharmaceutical Preparations;pharmacologic;Phenotype;Polyhydramnios, megalencephaly, and symptomatic epilepsy;prevent;Process;Proliferating;Prosencephalon;Radial;resistance mechanism;response;Seizures;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Sirolimus;stem cell model;stem cells;Structure;Syndrome;targeted treatment;Testing;Therapeutic;therapeutic target;therapy development;Tissue-Specific Gene Expression;Transcription Alteration;Transplantation;treatment strategy;Tuberous Sclerosis;Up-Regulation;Work

PROJECT_TITLE: Elucidating pathogenic mechanisms in STRADA-related brain malformation and epilepsy

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: NORTHRIDGE

ORG_DEPT: PHYSICS

ORG_NAME: CALIFORNIA STATE UNIVERSITY NORTHRIDGE

PHR: Project Narrative: This project will elucidate the key role of lipid intrinsic curvature in the mechanism of development of packing heterogeneity and preferential accumulation of cholesterol and the neurotoxic Aβ peptide in biological membranes.

PI_NAMEs: RANGANATHAN, RADHA  (contact)

PROGRAM_OFFICER_NAME: BERNAL, FEDERICO

PROJECT_TITLE: Intrinsic curvature induced packing heterogeneity and non-uniform distribution of cholesterol and Abeta peptide in lipid bilayers


NIH_SPENDING_CATS: Digestive Diseases;Genetics;Hepatitis;Hepatitis - B;Infectious Diseases;Liver Disease

ORG_CITY: HERSHEY

ORG_NAME: PENNSYLVANIA STATE UNIV HERSHEY MED CTR

PHR: PROJECT NARRATIVE Hepatitis B virus (HBV) is responsible for 257 million infection worldwide and currently there is no effective treatment to cure the disease. Nearly all high-resolution HBV structures published to date utilized E Coli expression system that either 1) lacks the nucleic acid binding domain, or 2) lacks post-translational modification, or 3) encapsidates non-viral nucleic acids; thus, making it difficult to correlate the observed structures with biomedical data. This proposal aims to dissect native high-resolution HBV structures from human hepatoma cells and will provide new structural insights that contribute to our understanding of disease pathogenesis.

PI_NAMEs: WANG, CHE-YEN  (contact)

PROGRAM_OFFICER_NAME: FLORES, AMANDA CHRISTINE

PROJECT_TERMS: Address;Animal Experiments;Anti-viral Agents;antiviral drug development;Arginine;Biology;C-terminal;Capsid;Capsid Proteins;Cell Culture System;Cell Culture Techniques;Cells;Classification;Complex;Cryoelectron Microscopy;Cytosol;Data;design;Disease;Double Stranded DNA Virus;ds-DNA;effective therapy;Electron Microscope;Embryo;Ensure;Environment;Enzymes;Escherichia coli;Exhibits;Future;Genome;Hepatitis B Therapy;Hepatitis B Virus;hepatoma cell;Human;Hydrophobicity;In Vitro;Infection;insight;Kidney;Knowledge;Lipids;Location;Mammalian Cell;Medical;Membrane Proteins;Methodology;Modeling;Molecular;Molecular Conformation;Molecular Structure;Molecular Virology;mutant;Mutation;N-terminal;novel;novel therapeutics;Nucleic Acid Binding;Nucleic Acids;particle;Pathogenesis;Phosphorylation;Physiological;Polymerase;Post-Translational Protein Processing;premature;prevent;Process;Protein Dephosphorylation;protein structure;Proteins;Public Health;Publishing;Reaction;reconstitution;Resolution;response;Reverse Transcription;RNA;RNA-Directed DNA Polymerase;Signal Transduction;Single-Stranded DNA;structural determinants;Structure;System;trafficking;Vaccines;Viral;Viral Envelope Proteins;Viral Genome;Viral Reverse Transcription;Virion;Virus Diseases;Virus Replication

PROJECT_TITLE: Structural characterization of native HBV capsids and virions from human cells

STUDY_SECTION: MSFC

STUDY_SECTION_NAME: Macromolecular Structure and Function C Study Section[MSFC]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: LEBANON

ORG_NAME: CELDARA MEDICAL, LLC

ORG_STATE: NH

PHR: In this application, we propose the establishment of the Alzheimer’s-focused Celdara Medical High-Potential Entrepreneurs’ Fellowship Program (A-CHEF). Successful completion of the aims and milestones outlined in this application will provide invaluable immersive training and career development to early-stage scientists, while simultaneously expanding the Alzheimer’s research workforce and advancing novel Alzheimer’s therapeutics toward the clinic and ultimately to patients.

PI_NAMEs: COLEMAN, JULIE H (contact)

PROGRAM_OFFICER_NAME: JOSEPH, LYNDON

PROJECT_TERMS: Academia;Active Learning;Aducanumab;Advisory Committees;Alzheimer's Disease;Alzheimer's disease therapeutic;apprenticeship;Award;Biological;biomedical scientist;Biotechnology;career;career development;Clinic;Clinical;cognitive function;Collaborations;college;Communication;COVID-19;COVID-19 pandemic;Development;Development Plans;Diagnosis;Disease;Doctor of Philosophy;drug development;Education;Educational Curriculum;effective therapy;Entrepreneurship;Evaluation;Feedback;Fellowship;Fellowship Program;flexibility;Funding;Grant;Immersion;improved;Individual;innovation;Intellectual Property;Intelligence;Laboratories;Leadership;Learning;lens;Maine;Medical;Medical center;Mentors;Mentorship;Names;National Institute of General Medical Sciences;next generation;novel;operation;Outcome;Patients;Persons;Phase;Pilot Projects;pre-clinical;preclinical development;Preparation;Process;programs;recruit;Research;responsible research conduct;Running;Scientist;Small Business Innovation Research Grant;Structure;success;Therapeutic;therapeutic development;Training;Training Programs;Universities;Writing

PROJECT_TITLE: Alzheimer's-focused Celdara Medical High-Potential Entrepreneurial Fellowship Program (A-CHEF)


ADMINISTERING_IC: AA

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Child Abuse and Neglect Research;Childhood Injury;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Physical Injury - Accidents and Adverse Effects;Prevention;Social Determinants of Health;Substance Misuse;Underage Drinking;Violence Against Women;Violence Research;Women's Health Research

ORG_CITY: NEW YORK

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: PROJECT NARRATIVE Hazardous drinking is the leading sexual orientation-related health disparity impacting sexual minority women (SMW; e.g., lesbian, bisexual). While this disparity has primarily been attributed to exposure to minority stress (e.g., discrimination, stigma), minority stress, alone, cannot fully explain hazardous drinking disparities between SMW and heterosexual women. Therefore, this study will examine how other factors, including risk factors (e.g., childhood sexual abuse) and potential mechanisms (e.g., emotion dysregulation, drinking expectancies), combine with minority stress to increase SMW's risk for hazardous drinking.

PI_NAMEs: BOCHICCHIO, LAUREN ANN (contact)

PROGRAM_OFFICER_NAME: KERRIDGE, BRADLEY TOWNSEND

PROJECT_TERMS: Accidents;Address;Adult;adverse childhood events;adverse outcome;Age of Onset;Alcohol consumption;Alcohol dependence;Alcohols;Anus;Bisexual;Black race;career;career development;Cause of Death;Characteristics;Chicago;Child Sexual Abuse;Chronic;Complex;Confounding Factors (Epidemiology);Conscious;Coping Behavior;Data;Development;Diagnostic;Discrimination;Disease;Disparity;drinking;effective intervention;emotion dysregulation;Emotional;Epidemiology;Ethnic Origin;Etiology;Expectancy;experience;Exposure to;Fellowship;forgetting;gender minority group;General Population;global health;Goals;Grant;hazardous drinking;Health;health disparity;Heart Diseases;Heterosexuals;High Prevalence;high risk;Homophobia;Individual;interest;Intervention;Joints;Knowledge;Latinx;Lesbian;Life Experience;Life Stress;Link;Literature;Liver diseases;longitudinal analysis;Longitudinal Studies;Malignant Neoplasms;Mediating;Mediation;Mentorship;Methodology;minority stress;minority stressor;Mission;Modeling;National Institute on Alcohol Abuse and Alcoholism;Outcome;outcome disparities;Pathway interactions;Pattern;Penetration;perpetrators;Persons;Phase;poor health outcome;Population;Positioning Attribute;Prevalence;Prevention strategy;Process;psychologic;Psychopathology;Public Health;Race;Reporting;Research;research data dissemination;response;Risk;Risk Factors;Role;Sampling;Severities;Sex Orientation;sexual identity;sexual minority;sexual minority group;sexual minority health;sexual minority stress;sexual minority women;skills;social;social stigma;Socioeconomic Status;Stress;substance use;Training;Trauma;United States National Institutes of Health;Vagina;Woman;Women's study;Writing

PROJECT_TITLE: Understanding the individual and combined impact of childhood sexual abuse and minority stress on hazardous drinking among sexual minority women: Is emotion dysregulation a key factor?


NIH_SPENDING_CATS: Cancer;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Hepatitis;Liver Cancer;Liver Disease;Prevention;Rare Diseases

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE Extracellular Vesicles (EVs) are present in circulation at a relatively early stage of hepatocellular carcinoma (HCC). The long-term goal of this R01 proposal is to develop and validate a streamlined HCC EV surface protein assay (SPA), capable of highly sensitive and specific quantification of 32 subpopulations of HCC EVs using plasma samples by synergistically integrating two very powerful platform technologies – i) a click chemistry- mediated EV isolation platform (i.e., EV Click Beads) and ii) downstream 4-plex real-time immuno-PCR for quantification of the isolated HCC EVs. The successful development of the proposed HCC EV SPA is rapidly translatable, enabling more sensitive and specific quantification of subpopulations of HCC-associated EVs to detect early-stage HCC.

PI_NAMEs: AGOPIAN, VATCHE ;TSENG, HSIAN-RONG ;ZHU, YAZHEN  (contact)

PROGRAM_OFFICER_NAME: YOUNG, MATTHEW R

PROJECT_TERMS: Address;Alcoholic Liver Diseases;Antibodies;ANXA5 gene;assay development;Bar Codes;Bioinformatics;Biological Assay;Biology;Biometry;Cancer Etiology;Case/Control Studies;CD81 gene;cell type;Cells;Cessation of life;Chemistry;Chronic Hepatitis B;circulating biomarkers;Circulation;Cirrhosis;Clinical;Clinical Practice Guideline;cohort;Couples;Coupling;detection assay;Development;Diagnosis;Diagnostic;diagnostic value;Disease;DNA;early detection biomarkers;Early Diagnosis;Etiology;Exhibits;extracellular vesicles;Filtration;Goals;GPC3 gene;Guidelines;Hepatitis B;Hepatitis C;hepatocellular carcinoma cell line;in-vitro diagnostics;innovation;Joints;lipid nanoparticle;Liver;Liver Cirrhosis;Liver diseases;Logistic Regressions;Mediating;Medical center;Membrane Proteins;Methods;Modality;molecular pathology;Motivation;neoplastic cell;non-alcoholic fatty liver disease;novel marker;Oncology;Operative Surgical Procedures;particle;Pathology;Patients;Performance;Phospholipids;Plasma;Precipitation;predictive modeling;Primary carcinoma of the liver cells;Primary Malignant Neoplasm of Liver;Prognosis;Protein Analysis;protein biomarkers;Quantitative Evaluations;Recommendation;Regression Analysis;Reproducibility;Research;Risk;Sampling;Sensitivity and Specificity;Serum;Site;Solid Neoplasm;Specificity;Specimen;Surface;TACSTD1 gene;Techniques;Technology;technology platform;Time;Training;tumor;tumor heterogeneity;tumor microenvironment;Tumor-Derived;Ultracentrifugation;Ultrasonography;ultrasound;Validation;Viral hepatitis;α-Fetoproteins

PROJECT_TITLE: Click Chemistry-Mediated Surface Protein Assay for Quantifying Subpopulations of Hepatocellular Carcinoma-associated Extracellular Vesicles

STUDY_SECTION: MCDC

STUDY_SECTION_NAME: Molecular Cancer Diagnosis and Classification Study Section[MCDC]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Aging

ORG_CITY: GAINESVILLE

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Public health relevance: Mobility disability impacts ~30% of individuals aged 60-69, 40% of individuals aged 70-79, and 55% of individuals age 80 or older. We propose to grow the research workforce to address mobility loss in older adults with the Translational Research training on Aging and Mobility postdoctoral training program.

PI_NAMEs: MANINI, TODD  (contact)

PROJECT_TITLE: Translational Research Training on Aging and Mobility (TRAM)


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Services;Patient Safety

ORG_NAME: HEBREW REHABILITATION CENTER FOR AGED

PHR: PROJECT NARRATIVE The proposed research aims to evaluate how frailty status changes the effectiveness and safety of drug and procedural therapy as well as health care costs and resource use in older adults. This research is relevant to public health because the evidence generated from this work can help clinicians and health care systems choose effective and safe treatments based on the frailty status. Thus, it accomplishes the National Institute on Aging's missions and initiatives by promoting individualized care to improve the health status of older adults.

PI_NAMEs: KIM, DAE HYUN  (contact)

PROGRAM_OFFICER_NAME: SALIVE, MARCEL

PROJECT_TERMS: Acceleration;Acupuncture Therapy;Acute;acute care;Address;Adverse event;Affect;Analgesics;Boston;Cardiac Surgery procedures;Cardiovascular Agents;Cardiovascular Diseases;Caring;Categories;Cessation of life;Chronic;Chronic low back pain;Chronic Obstructive Pulmonary Disease;Clinical;Clinical assessments;clinical care;clinical practice;Clinical Trials;clinically actionable;Communities;comorbidity;comparative effectiveness study;cost;COVID-19;critical limb Ischemia;Data;Decision Making;Delirium;Dementia;Diabetes Mellitus;Disabilities experience;disability;Drug Prescriptions;Effectiveness;Electronic Health Record;evidence base;experience;frailty;Funding;Goals;Health Care Costs;health management;Health Services Research;Health Status;Health system;Healthcare Systems;Heart failure;Hip Fractures;Home;hospital care;Hospitalization;Hospitals;improved;indexing;innovation;Institutionalization;Intensive Care Units;Investigation;Link;Massachusetts;Measurement;Measures;Medicare;medication safety;Methods;Mission;Modeling;National Institute on Aging;older adult;Operative Surgical Procedures;Osteoporosis;Outcomes Research;Participant;Patient Selection;Patient-Centered Care;Patients;Peripheral arterial disease;personalized care;Persons;Pharmaceutical Preparations;Pharmacoepidemiology;Pharmacotherapy;Pneumonia;poor health outcome;Population;population health;Pragmatic clinical trial;pragmatic trial;predictive modeling;programs;Provider;Public Health;Qualifying;Randomized, Controlled Trials;Research;Research Personnel;Resources;revascularization surgery;risk prediction;risk stratification;routine care;safety study;Sampling;Skilled Nursing Facilities;System;Testing;Time;treatment as usual;treatment effect;United States National Institutes of Health;Variant;venous thromboembolism;Ventilator;Work

PROJECT_TITLE: Applications of Claims-Based Frailty Index to Advance Evidence for Frailty-Guided Decision-Making

STUDY_SECTION: ODHS

STUDY_SECTION_NAME: Organization and Delivery of Health Services Study Section[ODHS]


ED_INST_TYPE: SCHOOLS OF EDUCATION

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Clinical Research;Neurodegenerative;Neurosciences;Parkinson's Disease

ORG_CITY: LOGAN

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UTAH STATE UNIVERSITY

ORG_STATE: UT

PHR: PROJECT NARRATIVE People with Parkinson's disease (PD) experience restricted communicative participation, which means that they have difficulty taking part in life situations where knowledge, information, ideas, or feelings are exchanged. The proposed project—utilizing dialogue theory, speech signal processing, causal inference, and a large corpus of 480 spoken dialogues—will permit identification of hypothesis-driven treatment targets to directly and effectively improve communicative participation of people with PD. This work addresses a critical gap in clinical practice and sets the stage for a subsequent well-informed, clinical trial within this new realm of clinical intervention.

PI_NAMEs: BORRIE, STEPHANIE ANNA (contact)

PROGRAM_OFFICER_NAME: KOPF, LISA MARIE

PROJECT_TERMS: Address;Adult;Behavior;Behavior assessment;Behavior Therapy;candidate identification;Case Study;Client;Clinical;clinical practice;Clinical Trials;Collection;Communication;Communication impairment;Coupled;design;Deterioration;Diagnosis;dyadic interaction;Dysarthria;Employment;expectation;experience;Feeling;Goals;improved;Individual;Intervention;Knowledge;Language;Life;life span;Literature;Maintenance;Modeling;multilevel analysis;Neurodegenerative Disorders;novel;open source tool;Outcome;Parkinson Disease;Patient Outcomes Assessments;Periodicity;Personal Satisfaction;Persons;Population;Problem Solving;Quality of life;repaired;Research;research clinical testing;Research Design;Research Personnel;Role;Services;signal processing;Social isolation;Speech;Statistical Models;success;Techniques;theories;Variant;Verbal Behavior;Work

PROJECT_TITLE: A causal framework of communicative participation in people with Parkinson's disease.

STUDY_SECTION: LCOM

STUDY_SECTION_NAME: Language and Communication Study Section[LCOM]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

ORG_CITY: HADLEY

ORG_NAME: UNIVERSITY OF MASSACHUSETTS AMHERST

PHR: PROJECT NARRATIVE The proposed research will address a critical public health problem, fatigability- a predictor of future mobility problems in aging, by determining biomechanical and energetic consequences of greater muscle fatigue in older adults. Our innovative, translational approach, which combines state-of-the-art experimental and computational approaches from tissue to behavioral levels, will provide the new information necessary to bridge an existing knowledge gap and thus enable translation of basic science to public health. Our mechanistic outcomes of fatigability will identify promising targets for intervention to mitigate or prevent fatigability and related mobility decline in our aging population, as such, this project is highly relevant to the missions of NIH and NIA.

PI_NAMEs: BOYER, KATHERINE ALAINE (contact)

PROJECT_TERMS: Acceleration;Address;Adult;Age;age effect;age related;age related changes;Aging;aging population;Ankle;ankle joint;Basic Science;Behavioral;Biomechanics;Chronic;clinically relevant;Computer Simulation;cost;Data;Deterioration;disability;Distal;efficacious intervention;Electromyography;Energy consumption;Evidence based intervention;Exertion;experience;Extensor;Fatigue;Flexor;Future;Gait;Gait speed;Goals;healthspan;Hip region structure;Impairment;In Situ;in vivo;Indirect Calorimetry;Individual;innovation;Intervention;Knee;Knee joint;Knowledge;Link;Lower Extremity;Magnetic Resonance Imaging;Measures;Mechanics;men;Metabolic;middle age;Mission;Mobility decline;Modeling;models and simulation;Motion;Muscle;Muscle Fatigue;Muscle Weakness;Musculoskeletal;Musculoskeletal Equilibrium;Neuromechanics;neuromuscular function;neuroregulation;novel;older adult;older men;Older Population;older women;Outcome;Pathway interactions;Performance;Physical activity;Physical Performance;Physiological;Population;prevent;Protocols documentation;Public Health;Research;response;Risk;Role;sedentary;sex;simulation;spatiotemporal;Standardization;success;Testing;therapy design;Tissues;Torque;translational approach;Translations;treadmill;United States National Institutes of Health;Walking;Woman;young adult

PROJECT_TITLE: Muscle Fatigue, Gait Alterations and Increased Energy Cost of Walking in Aging

STUDY_SECTION: MRS

STUDY_SECTION_NAME: Musculoskeletal Rehabilitation Sciences Study Section[MRS]


NIH_SPENDING_CATS: Genetics;Neurosciences

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

PHR: Project Narrative Type II spiral ganglion neurons innervate the outer hair cells of the cochlea and have nociceptive characteristics that enable them to detect hair cell loss or damage. This project will define developmental mechanisms guiding cochlear innervation by studying these type II neurons and the axon guidance events that turn their peripheral axons towards the cochlear base in order to contact multiple outer hair cells. Understanding these developmental mechanisms is necessary for the repair of auditory circuits following acoustic trauma and to promote cochlear re-innervation during the course of regeneration-based deafness therapy.

PI_NAMEs: PARK, SUNG JIN  (contact)

PROGRAM_OFFICER_NAME: FREEMAN, NANCY

PROJECT_TERMS: Acoustic Trauma;Acoustics;Affect;Auditory;Axon;axon guidance;base;Binding Sites;cell injury;Cell membrane;Cells;Characteristics;Chemicals;ChIP-seq;Cochlea;Complex;conditional knockout;conditional mutant;Cues;Data;deaf;deafness;Defect;Development;Developmental Process;Dominant-Negative Mutation;Ensure;Eph Family Receptors;Ephrin-A3;Ephrins;Epithelium;Event;experimental study;Gene Deletion;Genetic;Genetic Transcription;Goals;Growth Cones;Hair Cells;Image;inducible Cre;Inner Hair Cells;Knock-out;Knowledge;Label;Laboratories;Ligands;Membrane;migration;Minority;Motility;Mus;mutant;Natural regeneration;nerve supply;neurodevelopment;neuron development;neuronal growth;Neurons;Nociception;Nociceptors;Noise;Organ of Corti;Outer Hair Cells;Pathology;Pathway interactions;Pattern;Peripheral;Phenotype;planar cell polarity;preservation;promoter;Proteins;receptor;reinnervation;repaired;Reporting;Research;Research Design;Sensory;Sensory Hair;Signal Pathway;Signal Transduction;Site;sound;spiral ganglion;Supporting Cell;Supporting Cell of Organ of Corti;Synapses;Testing;Therapeutic;transcription factor;transcriptome sequencing;Transgenes

PROJECT_TITLE: Mechanisms of PCP signaling in axon guidance and cochlear innervation

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Hepatitis;Liver Disease;Nutrition

ORG_CITY: LA JOLLA

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative In the first project period, we discovered negative crosstalk between the SCAP-dependent and caspase 2 (Casp2)-dependent SREBP activation pathways. Whereas SCAP-dependent SREBP activation dominates in simple steatosis, Casp2-dependent SREBP activation dominates in ER-stressed livers, which progress to steatohepatitis. We now plan to investigate how the crosstalk between the two SREBP activation pathways controls progression to non-alcoholic steatohepatitis (NASH) and its suitability for therapeutic intervention.

PI_NAMEs: KARIN, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: BURGESS-BEUSSE, BONNIE L

PROJECT_TERMS: Ablation;Adult;Affect;Attenuated;Benign;Biopsy;burnout;CASP2 gene;Cholesterol Homeostasis;Collection;Complex;Consumption;Diet;Endoplasmic Reticulum;endoplasmic reticulum stress;Enzymes;Equilibrium;Fatty acid glycerol esters;Fatty Acids;Fatty Liver;Feedback;Fibrosis;Foundations;Fructose;Genetic;Hepatic;Hepatocyte;High Fat Diet;Human;Inflammation;inhibitor;Inositol;Insulin Resistance;Link;lipid biosynthesis;Lipids;Liver;liver inflammation;liver injury;Mediating;Mediator;Membrane;Metabolic Diseases;Modeling;mouse model;mRNA Translation;Mus;new therapeutic target;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;novel;novel therapeutic intervention;Pathogenesis;Pathogenicity;Pathway interactions;pharmacologic;Predisposition;prevent;protein activation;Regulation;Research;Role;Scaffolding Protein;sensor;Signal Transduction;simple steatosis;site-1 protease;Solid;Specimen;spheroids;SRE-1 binding protein;Steatohepatitis;Sterols;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;Time;transcription factor;transcriptomics;Transducers;western diet;Wild Type Mouse;XBP1 gene

PROJECT_TITLE: Control of Lipogenesis and Hepatic Steatosis by Caspase-2

STUDY_SECTION: POMD

STUDY_SECTION_NAME: Pathophysiology of Obesity and Metabolic Disease Study Section[POMD]


ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: PROJECT NARRATIVE It is important to understand the means by which microbes infect and cause disease in humans, to discover how to control the waves of pestilence that have spread through regions of the world. This training program proposes to train seven young scientists in the theory and methods they need to investigate the mechanisms through which these pathogens parasitize and cause infectious diseases of humans.

PI_NAMEs: BUTLER, NOAH SULLIVAN;WEBER, MARY ;WILSON, MARY E (contact)

PROGRAM_OFFICER_NAME: SASTALLA, INKA I

PROJECT_TERMS: parasitism;Training

PROJECT_TITLE: Training in Mechanisms of Parasitism

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases Advisory Committee[MID]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Dissemination and Implementation Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Opioid Misuse and Addiction;Opioids;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Substance Misuse

ORG_CITY: BALTIMORE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Increasing access to medications for opioid use disorder could dramatically reduce risk of overdose and other negative health outcomes after release from jail, but these medications are often not available during and after jail stays. In this project, we study the public health impact of a statewide law in Maryland requiring local jails to provide access to medication during incarceration with linkage to care after release.

PI_NAMEs: KENNEDY HENDRICKS, ALENE  (contact);SALONER, BRENDAN K

PROGRAM_OFFICER_NAME: ZUR, JULIA BETH

PROJECT_TERMS: access disparities;Adopted;Affect;Area;behavioral health;Black race;Buprenorphine;Caring;Communities;community reentry;community setting;comparative;Complex;Counseling;Data;data warehouse;Diffuse;Disparity;Ensure;Environment;ethnic disparity;Ethnic Origin;Ethnic Population;Evaluation;experience;Exposure to;Future;Goals;Grant;Health;Health Benefit;Health Personnel;Health Services Accessibility;Healthcare;Hispanic;Hospitalization;Hospitals;implementation evaluation;implementation measures;implementation process;Imprisonment;improved;Incentives;Individual;innovation;insight;Interruption;Intervention;Interview;Jail;Laws;Life;Link;Maryland;Measures;Medical Examiners;Medical Staff;medication for opioid use disorder;Methadone;Methods;Minority Groups;Modeling;Naltrexone;Natural experiment;Not Hispanic or Latino;Opioid;opioid use disorder;Outcome;outcome disparities;Overdose;overdose death;Overdose reduction;overdose risk;Patients;Persons;Pharmaceutical Preparations;Phase;Policies;Policy Analysis;Population;prescription monitoring program;Prisons;programs;Provider;Public Health;Race;racial disparity;racial population;recidivism;Records;Reporting;Resources;Risk;Risk Reduction;Role;Rural;Rural Community;scale up;screening;Series;Shapes;social stressor;Statutes and Laws;structural determinants;Structure;Subgroup;System;Time;tool;Treatment outcome;treatment program;Vital Statistics;Withdrawal

PROJECT_TITLE: Impact of a Maryland Law Requiring Jails to Provide Medications for Opioid Use Disorder on Recently Incarcerated People.


ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative Metabolic syndrome (MS), characterized by a cluster of conditions including dyslipidemia, central abdominal obesity, insulin resistance, and high blood pressure, is prevalent in people living with HIV (PLWH), and puts them at greater risk of cardiovascular events. Intestinal dysbiosis, compromised intestinal barrier integrity and associated inflammation has been linked with MS in certain populations, but whether this is a driving factor of high levels of MS in HIV+ MSM has not been deeply explored. This proposal couples multi'omic interrogation of intestinal biopsy samples from HIV+ and negative MSM with and without MS and mechanistic studies in innovative in vitro systems and gnotobiotic mice to test the hypothesis that intestinal dysbiosis impacts gut barrier function in HIV+ MSM, and that this promotes MS via the translocation of microbial products.

PI_NAMEs: COLGAN, SEAN P;LOZUPONE, CATHERINE  (contact);PALMER, BRENT E

PROGRAM_OFFICER_NAME: GREENWEL, PATRICIA

PROJECT_TERMS: Automobile Driving;Back;Bacteria;bacterial community;Bacterial Translocation;Biological Markers;Biopsy Specimen;Butyrates;cardiovascular risk factor;Central obesity;Chronic;Chronic Kidney Failure;comorbidity;Couples;Defect;Development;Diet;dysbiosis;Dyslipidemias;Enzymes;Epithelium;Event;Exhibits;Exposure to;Feces;Functional disorder;Gene Expression;Germ-Free;Gnotobiotic;gut bacteria;gut microbes;gut microbiome;Health;HIV;HIV Seronegativity;HIV Seropositivity;Human;Hypertension;Immune;improved;In Vitro;Individual;Inflammation;Inflammatory;inflammatory marker;innovation;Insulin Resistance;intestinal barrier;intestinal epithelium;Intestinal Mucosa;Intestines;Link;lipopolysaccharide-binding protein;Measures;men who have sex with men;Metabolic;Metabolic Diseases;Metabolic Marker;Metabolic syndrome;Microbe;microbial;microbial products;microbiome;microbiome composition;Mucins;Mucolytics;multiple omics;Mus;Obesity;Pathway Analysis;Persons;Phenotype;Plasma;Population;Process;Production;protein expression;Role;Sialic Acids;System;systemic inflammatory response;Testing;Tight Junctions;transcriptomics;tributyrin;Water;Work

PROJECT_TITLE: Gut microbiome effects on intestinal barrier function and metabolic syndrome in HIV positive men who have sex with men


ORG_NAME: CHILDREN'S HOSPITAL OF LOS ANGELES

ORG_STATE: CA

PHR: PROJECT NARRATIVE Immunotherapy using a patient’s own engineered T cells has revolutionized the treatment of relapsed leukemia in children, but this therapy has not been nearly as effective for solid tumors. Therefore, children with relapsed solid tumors remain in dire need of alternative therapies. This project aims to investigate how we can increase the potency of these engineered T cells in order to target solid tumors that have been resistant to T cell therapy.

PI_NAMEs: RICHMAN, SARAH ANN (contact)

PROGRAM_OFFICER_NAME: LIM, SUSAN E

PROJECT_TERMS: Address;Advisory Committees;Affinity;Alternative Therapies;antigen binding;Antigen Receptors;Antigens;Attenuated;Behavior;Binding;cancer care;CAR T cell therapy;career development;CD19 gene;Cell Count;Cell Death;Cell Survival;Cells;Cellular biology;Child;Childhood Leukemia;chimeric antigen receptor;chimeric antigen receptor T cells;Clinical;Cytoplasmic Granules;cytotoxic;cytotoxicity;Data;design;differentiation in vitro;engineered T cells;Environment;Equilibrium;Event;experience;Flow Cytometry;Fluorescence Microscopy;Goals;Image;immunological synapse;Immunology;Immunotherapy;Impairment;improved;In Vitro;in vivo;inhibitor;Investigation;Kinetics;leukemia;leukemia relapse;leukemia/lymphoma;Lymphocyte;Mediator;MEKs;Memory;Mentors;Mentorship;microscopic imaging;Microscopy;Modality;Outcome;Pathway interactions;Patient Care;Patients;Phenotype;Phosphoproteins;Physicians;Positioning Attribute;Publishing;Refractory;Relapse;Resistance;response;Role;Scientist;Signal Pathway;Signal Transduction;Signaling Molecule;skills;Solid Neoplasm;T Cell Receptor Signaling Pathway;T cell therapy;T-Cell Receptor;T-Lymphocyte;Techniques;Testing;Therapeutic;Training;translatable strategy;tumor microenvironment;Variant;Western Blotting;Work

PROJECT_TITLE: The role of antigen binding strength in CAR T cell activity

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

PHR: PROJECT NARRATIVE: Brain Derived Neurotrophic Factor (BDNF) is a growth factor that is essential for neuronal survival, differentiation, development, and plasticity. Transcriptional regulatory mechanisms provide the specificity required for the appropriate upregulation of BDNF in response to a wide variety of conditions and stimuli, which thereby allows for proper neuronal functioning. This proposal aims to identify and determine the specificity provided by enhancers, non-coding regulatory regions of the genome, in Bdnf regulation and as such will increase our understanding of the fundamental mechanisms that link BDNF’s expression and functions to sensory stimuli.

PI_NAMEs: NARAYANAN, ARTHY  (contact)

PROGRAM_OFFICER_NAME: TYLER, WILLIAM A

PROJECT_TERMS: Address;BDNF gene;Binding;Binding Sites;Biochemical;Biological Assay;Brain-Derived Neurotrophic Factor;cell type;Characteristics;Chimeric Proteins;ChIP-seq;Chromatin;Chromatin Loop;Clustered Regularly Interspaced Short Palindromic Repeats;conditioned fear;Coupling;CRISPR/Cas technology;Data;Data Set;Development;Distal;Enhancers;epigenome editing;experience;fear memory;Fright;Gene Expression;Gene Expression Regulation;Genes;Genetic Transcription;Genome;Goals;Growth Factor;Guide RNA;Hippocampus;impaired brain development;Impairment;In Situ Hybridization;in vivo;Induced Neurons;Learning;Link;Logic;Luciferases;Measures;Mediating;Memory;Messenger RNA;Methods;Molecular Conformation;Mus;neural circuit;neuronal survival;Neurons;NPAS4 gene;Nucleic Acid Regulatory Sequences;Play;promoter;protein expression;Publishing;recruit;Regulation;Regulatory Element;Reporter;Repression;response;RNA;Role;sensory stimulus;Signal Transduction;Specificity;Stimulus;Techniques;Testing;transcription factor;Transcriptional Regulation;Transfection;Transgenic Organisms;Untranslated RNA;Up-Regulation

PROJECT_TITLE: Enhancer-Mediated BDNF Regulation


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Prevention

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative Infections due to antibiotic-resistant bacteria known as Enterobacterales are occurring increasingly in the community in otherwise healthy persons without significant prior health care contact. Our goal is to identify community-based exposures to resistant bacteria by examining carriage in healthy persons and potential household environmental sources. Our results will lead to ways to control the sources that we find and to decrease the risk of antibiotic-resistant bacterial infections in the community.

PI_NAMEs: LOGAN, LATANIA K. (contact)

PROGRAM_OFFICER_NAME: ERNST, NANCY L

PROJECT_TERMS: Adult;Antibiotic Resistance;Antibiotics;Automobile Driving;Bacterial Antibiotic Resistance;Bacterial Infections;bacterial resistance;Base Sequence;beta-Lactamase;biobank;Biological Specimen Banks;built environment;candidate identification;Cessation of life;Chicago;Child;Childhood;Clinical;clinical candidate;Communities;community setting;community transmission;cost;Cyclophosphamide;Data;Data Collection;Detection;Ecology;Elements;Environment;Environmental Pollution;Epidemic;Epidemiologic Factors;Epidemiology;Event;Expenditure;Exposure to;Extended Spectrum Beta lactamase producing Enterobacterales;Future;Genes;Genetic;genome sequencing;Geography;Goals;health care service utilization;health care settings;Healthcare;High Prevalence;Hospitals;Household;Human;human data;Incidence;Individual;Infection;Infection prevention;insight;Interruption;Intervention;Investigation;Knowledge;Length of Stay;Link;Measures;member;Metadata;methicillin resistant Staphylococcus aureus;Molecular;Multi-Drug Resistance;novel;Outcome;Participant;pathogen;Pathway interactions;Patients;Persons;Predisposition;Prevalence;prevent;Prevention strategy;Preventive;prospective;Prospective Studies;Public Health;Reporting;Research;Resistance;resistance gene;resistant strain;Risk;Role;Route;sample archive;Sample Size;Sampling;Site;Source;Specialist;Specific qualifier value;Surface;transmission process;Virulent;whole genome;Writing

PROJECT_TITLE: Households as Reservoirs of Community-Acquired Extended-Spectrum Beta-Lactamase-producing Enterobacterales

STUDY_SECTION: PRID

STUDY_SECTION_NAME: Population based Research in Infectious Disease Study Section[PRID]


NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Brain Disorders;Clinical Research;Epilepsy;Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects;Rehabilitation;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_CITY: Los Angeles

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: PROJECT NARRATIVE For patients with upper extremity dysfunction caused by strokes, brain trauma, or spinal cord injury, brain- machine interface (BMI) technologies may one day restore function by utilizing cortical neural signals to control the movements of a robotic limb with multiple degrees of freedom. However, the current generation of BMI devices are guided by visual feedback alone, without somatosensory feedback. Our proposal is designed to increase our understanding of sensorimotor integration by examining how varying stimulation parameters affect perceived somatosensation (Aim 1), examine task performance using artificial somatosensation versus native touch (Aim 2), and compare real touch to artificial somatosensation for response time (Aim 3).

PI_NAMEs: LEE, BRIAN  (contact)

PROGRAM_OFFICER_NAME: REZAIZADEH, KAVON PAUL

PROJECT_TERMS: Affect;Area;Behavioral;Biomedical Engineering;Biometry;brain machine interface;Clinical;Complex;deep brain stimulator;density;design;Device or Instrument Development;Devices;Discrimination;Electric Stimulation;Electrocorticogram;Epilepsy;Equilibrium;Esthesia;Feedback;Foundations;Freedom;Frequencies;Functional disorder;functional restoration;Funding;Future;Generations;Goals;grasp;Hand;Human;Implant;Learning;Left;Light;limb movement;Limb structure;Liquid substance;Maps;Medical Device;Mentored Patient-Oriented Research Career Development Award;Mentors;Monitor;Motor;motor control;Movement;Movement Disorders;multidisciplinary;Nervous System Disorder;neural model;neurophysiology;neuroprosthesis;Neurosurgeon;neurotransmission;Output;Participant;Patients;Perception;Performance;Physiologic pulse;Positioning Attribute;pressure;Publishing;Reaction Time;Recording of previous events;recruit;Research Design;Research Personnel;response;retinal prosthesis;Robotics;Scientist;Seizures;Self-Help Devices;Sensory;Shapes;somatosensory;Somatosensory Cortex;Speed;Spinal cord injury;Stroke;success;Surface;Task Performances;Technology;Temperature;Testing;Therapeutic;Time;Touch sensation;Traumatic Brain Injury;United States National Institutes of Health;Upper Extremity;Vagus nerve structure;vibration;vibration perception;virtual;Vision;visual feedback;Width

PROJECT_TITLE: Decoding / encoding somatosensation from the hand area of the human primary somatosensory (S1) cortex for a closed-loop motor / sensory brain-machine interface (BMI)


NIH_SPENDING_CATS: Microbiome;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: NARRATIVE Developmental Origins of Health and Disease (DOHaD) is a well-accepted concept that exposures during early life (fetal and newborn periods) influence individual’s health and disease risk across the life span. The major contributing factors include environmental toxicants, nutrition, microbiome, stress, hormones, metabolites, drugs, and alcohol. The US DOHaD Society’s missions are to promote diversity and inclusion in the Society’s leadership, to facilitate collaborative studies on these important factors in order to understand their roles in health and disease, and to bring together clinicians, toxicologists, epidemiologists, nutritionists, physiologists, and basic scientists to develop novel preventive strategies, advocate for sound public policy, and ultimately improve the health of Americans.

PI_NAMEs: TRAN, PHU V. (contact)

PROGRAM_OFFICER_NAME: SCHUG, THADDEUS

PROJECT_TERMS: Advocate;Alcohols;American;Area;Australia;Award;Awareness;Biological Markers;Biomedical Research;career;career development;Child Development;Choline;Chronic Disease;Cities;Collaborations;cost;COVID-19;COVID-19 pandemic;Data;Dedications;Development;Developmental Biology;Disease;disorder risk;diversity and inclusion;Endocrine Disruptors;Endocrinology;Ensure;Environment;environmental chemical;environmental chemical exposure;Environmental Exposure;environmental toxicology;Epidemiologist;Epidemiology;epigenomics;Ethnic Origin;Event;exosome;experience;Exposure to;Faculty;Fellowship;fetal;Fetal Development;Folic Acid;Fostering;Funding;Future;Gender;gender minority;Generations;Goals;Government Agencies;graduate student;Grant;gut microbiota;Health;Heat Stress;Hormones;Human Development;Hybrids;improved;indexing;Individual;Industry;Institution;interest;International;Intervention;Investigation;Kansas;Knowledge;Lactation;late life;Leadership;Life;Life course epidemiology;life span;Long-Term Effects;Malignant Neoplasms;Mammals;maternal microbiota;Measures;Medical;meetings;Methodology;Michigan;microbiome;Minnesota;Minority;Minority Groups;Minority Recruitment;Mission;multidisciplinary;National Institute of Environmental Health Sciences;Netherlands;Newborn Infant;North Carolina;novel;Nutrient;nutrition;Nutritionist;offspring;Outcome;Participant;pathogen;Pathology;Pediatric Hospitals;Perinatal;Persons;Pharmaceutical Preparations;Pharmacologic Substance;Physicians;Postdoctoral Fellow;pre-doctoral;Pregnancy;prevent;Prevention strategy;Productivity;programs;Public Health Applications Research;Public Policy;recruit;Research;Research Methodology;Research Personnel;Risk;Role;Science;Scientist;sex;Singapore;societal costs;Societies;sound;Source;South Africa;Stress;stressor;Students;success;Surveys;symposium;Toxic Environmental Substances;toxicant;Toxicology;Training;Travel;Underrepresented Minority;Underserved Population;United States;United States National Institutes of Health;Universities;virtual;Woman;Writing

PROJECT_TITLE: 2022-2024 US DOHaD Society Meetings


ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

PHR: RELEVANCE The continuing decrease in the number of surgeon-scientists may significantly limit opportunities for future scientific discovery and innovation, and mounting evidence suggests that this decline is due to a ‘pipeline’ problem. Trainees in Otolaryngology-Head and Neck Surgery and the Communication Sciences can face geographic, financial, and systemic barriers that may discourage pursuit of a career as a surgeon-scientist, thus new and innovative approaches are needed to encourage careers in research and to provide research training and effective mentorship. The Research Symposium for Clinician-Scientist Development in Otolaryngology and the Communication Sciences will address this problem by organizing a ‘Research Boot Camp’ that provides instruction, mentorship, and career development tools for attendees.

PI_NAMEs: MOBERLY, AARON C (contact);TURNER, JUSTIN H

PROGRAM_OFFICER_NAME: RIVERA-RENTAS, ALBERTO L

PROJECT_TERMS: Address;Area;Award;Basic Science;Biomedical Research;career;career development;Clinical;clinical practice;cohort;Communication;comparative;Complex;Data Analyses;Development;Disease;Disparity;early-career faculty;education research;Educational Curriculum;Educational workshop;effectiveness evaluation;equity, diversity, and inclusion;Event;experience;Extramural Activities;Face;Faculty;Feedback;Financial Hardship;Foundations;Functional disorder;Funding;Future;Geography;Goals;Grant;Head and Neck Surgery;Health;Human Biology;improved;innovation;Institution;Instruction;interest;Investments;Laboratories;Lead;lectures;Life;Manuscripts;Medical;medical schools;medical specialties;Medical Students;Mentors;Mentorship;Methods;minority trainee;Modification;National Institute on Deafness and Other Communication Disorders;novel strategies;Operative Surgical Procedures;Otolaryngologist;Otolaryngology;Outcome;outreach;Participant;Patient Care;Patients;Performance;Physicians;Positioning Attribute;Professional Burnout;programs;Publications;recruit;Research;Research Design;Research Methodology;Research Personnel;Research Support;Research Training;Resources;Risk;role model;Science;science education;Scientist;Secure;Side;skills;social;social media;success;Surgeon;symposium;systemic barrier;tool;tool development;Training Programs;Translating;Translational Research;Travel;Underrepresented Minority;United States National Institutes of Health;web page;Woman

PROJECT_TITLE: Early Career Development of Clinician-scientists in Otolaryngology and the Communication Sciences

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


FUNDING_MECHANISM: SBIR-STTR RPGS

ORG_CITY: Pasadena

ORG_NAME: SPATIAL GENOMICS, INC.

PHR: NARRATIVE Mapping the spatial organization of the human brain at cellular resolution from single cell gene expression profiles is essential to understanding the function of neurocircuits in the brain. Spatial Genomics has developed a technology to map cell populations and molecular states of single cells in their native environment. This technology can identify cell types and the spatial interactions between neurons and glia in the brain to generate a spatial map with molecular information.

PI_NAMEs: FRIEDA, KIRSTEN  (contact)

PROGRAM_OFFICER_NAME: ANDERSON, PAIGE MARIE

PROJECT_TERMS: 3-Dimensional;Antibodies;Biological Assay;Brain;Brain Mapping;brain tissue;cell type;Cells;Chromatin;commercialization;Computer software;Data;Data Set;Devices;DNA;DNA Integration;DNA Probes;empowerment;Environment;Epigenetic Process;epigenome;experience;experimental study;Fluorescence;Fluorescent in Situ Hybridization;Gene Expression Profile;Gene Order;Gene Targeting;Genes;Genetic Markers;Genetic Transcription;Genomics;Goals;Human;Image;imaging platform;Immunofluorescence Immunologic;In Situ;instrument;Introns;Maps;Marketing;Measurement;Messenger RNA;Methods;Modality;Modeling;Molecular;Molecular Conformation;Morphology;multimodality;multiple omics;Mus;Neuroglia;neuronal circuitry;Neurons;novel;Pathway interactions;Pattern;Population;preservation;Process;protein biomarkers;Proteins;Reagent;Research Personnel;Resistance;Resolution;RNA;RNA Degradation;RNA marker;Sampling;Signal Transduction;single cell sequencing;single-cell RNA sequencing;Slice;Stains;System;targeted imaging;Technology;Time;Tissues;tool;transcriptome;Translational Research

PROJECT_TITLE: Multi-modal spatial genomics in the mouse and human brains

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-NV-G(13)B]