NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biomedical Imaging;Clinical Research;Emerging Infectious Diseases;Infectious Diseases;Lung;Machine Learning and Artificial Intelligence;Prevention;Rare Diseases;Tuberculosis

ORG_CITY: Newark

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: PROJECT NARRATIVE Detecting and treating tuberculosis (TB) before it becomes infectious or leads to disability is critical to TB control. We propose to use artificial intelligence combined with digital chest imaging (computed tomography and chest-X-rays) to develop a high-precision imaging toolset to characterize and diagnose early TB disease.

PI_NAMEs: XIE, YINGDA LINDA (contact)

PROGRAM_OFFICER_NAME: LACOURCIERE, KAREN A

PROJECT_TERMS: Acceleration;Algorithms;Area;Artificial Intelligence;Bacteria;Biological Markers;case finding;Characteristics;Chest imaging;Clinical;clinically relevant;computer aided detection;Data Set;Death Rate;Detection;detection platform;Development;Diagnosis;Diagnostic;digital;disability;Disease;Disease Progression;disease transmission;Early Diagnosis;Early treatment;effective therapy;Epidemiology;Evolution;Gene Expression Profile;Goals;High Resolution Computed Tomography;high resolution imaging;Household;Image;image guided;imaging biomarker;Imaging Device;imaging modality;improved;Individual;Infection;Intervention;Knowledge;Lesion;Machine Learning;meetings;Methods;Microscopic;Morbidity - disease rate;Mycobacterium tuberculosis;Onset of illness;Pathologic;Pathology;Pattern;Performance;personalized diagnostics;personalized medicine;Persons;Phenotype;predictive modeling;Predictive Value;prevent;Preventive therapy;Preventive treatment;progression marker;progression risk;prospective;radiomics;Regimen;Research;Resolution;Risk;risk prediction;ROC Curve;Scanning;Signs and Symptoms;Sputum;Symptoms;targeted treatment;Testing;Texture;Thoracic Radiography;tool;Training;transfer learning;transmission process;Treatment Protocols;treatment response;Tuberculosis;tuberculosis drugs;tuberculosis treatment;Validation;X-Ray Computed Tomography

PROJECT_TITLE: Imaging signatures of early tuberculosis

STUDY_SECTION: PRID

STUDY_SECTION_NAME: Population based Research in Infectious Disease Study Section[PRID]


ADMINISTERING_IC: AI

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Genetics;Infectious Diseases;Sexually Transmitted Infections

ORG_CITY: HOUSTON

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PATHOLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: NARRATIVE Although identified over 100 years ago, Treponema pallidum, the spiral-shaped bacterium that causes syphilis and related diseases, could not be grown in vitro, i.e. in a test tube, until 2018 when our laboratory achieved continuous in vitro multiplication of T. pallidum. The T. pallidum in vitro culture system is complex, including tissue culture cells, a specialized medium, and incubation under low concentrations of oxygen (1.5%), but appears to serve as an excellent replacement for the traditional method of growing T. pallidum in rabbits. In this project, we plan to optimize and simplify the culture system so that it can be used readily for research purposes, and we will also introduce mutations into the genes of T. pallidum to gain a better understanding of how the proteins they produce help this organism causes debilitating infections that can last for decades.

PI_NAMEs: EDMONDSON, DIANE G (contact)

PROGRAM_OFFICER_NAME: VINCENT, LEAH REBECCA

PROJECT_TERMS: Admission activity;Affect;Amino Acids;Animals;Anti-microbial susceptibility;axenic culture;Bacteria;Biochemical Pathway;Biological Models;Biology;Calcium;Cells;Cloning;Coculture Techniques;Complement;Complex;computational suite;computerized tools;Cystine;Data;Development;Disease;Electroporation;Epithelial Cells;Essential Genes;Ethics;evidence base;Excretory function;experimental study;Gene Expression;Gene Expression Profile;gene function;Generations;Genes;Genetic;genetic analysis;genetic approach;Goals;Growth;Harvest;human pathogen;Immunity;In Vitro;Incidence;Incubated;Individual;Infection;insight;Isotopes;Keto Acids;Label;Laboratories;Libraries;Mammalian Cell;Maps;Mediating;Metabolic;Metabolism;metabolomics;Methods;Modeling;Molecular;Morphology;Motility;Mutagenesis;mutant;Mutation;Mutation Analysis;Nitrogen;novel;Nutritional;Nutritional Requirements;Organism;Oryctolagus cuniculus;Other Genetics;Oxygen;Pathogenesis;Pattern;Peptidoglycan;Physiology;Population;Procedures;Proteins;Reaction;Reporting;Research;Research Personnel;Role;Sexually Transmitted Diseases;Shapes;Site;Site-Directed Mutagenesis;Stable Isotope Labeling;Structure;Syphilis;System;Techniques;Testing;tissue/cell culture;transamination;transposon sequencing;Treponema pallidum;Treponema pallidum subspecies pallidum;Tube;United States;vector;Virulence

PROJECT_TITLE: Factors Affecting longterm in vitro culture of Treponema pallidum

STUDY_SECTION: PCMB

STUDY_SECTION_NAME: Prokaryotic Cell and Molecular Biology Study Section[PCMB]


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Adolescent Sexual Activity;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Contraception/Reproduction;Dissemination and Implementation Research;Pediatric;Prevention;Social Determinants of Health;Teenage Pregnancy;Women's Health Research

ORG_DEPT: PSYCHOLOGY

PHR: Disseminating Effective Sexual Health Programs in Schools using iCHAMPSS  Project Narrative The proposed research is relevant to public health because it seeks to address teen births, a major public health problem in the U.S., by establishing the effectiveness of an innovative implementation strategy to increase the adoption, implementation, and maintenance of effective sexual health programs in schools. The research is expected to result in an implementation strategy that can be replicated in other communities. Thus, the proposed research is relevant to the part of the NICHD's mission to lead research and training to enhance the lives of children and adolescents.

PI_NAMEs: HERNANDEZ, BELINDA FLORES (contact)

PROGRAM_OFFICER_NAME: POPKIN, RONNA

PROJECT_TERMS: Address;Adolescent;Adopted;Adoption;adverse outcome;aged;Area;Birth;Birth Rate;Child;Communities;Complex;Consolidated Framework for Implementation Research;Cost Analysis;design;Developed Countries;dosage;Education;Educational Curriculum;Effectiveness;effectiveness testing;Evaluation;evidence base;Evidence based program;experience;Female;Future;Goals;Health education;high risk sexual behavior;High School Student;implementation facilitators;implementation outcomes;implementation research;implementation strategy;improved;Infant;innovation;Knowledge;knowledge base;Laws;Lead;Left;Maintenance;Middle School Student;Mission;Monitor;National Institute of Child Health and Human Development;Needs Assessment;Online Systems;Outcome;Parental Notification;Phase;pilot test;Policies;Pregnancy in Adolescence;Pregnancy Rate;primary outcome;Process;process evaluation;programs;Public Health;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Reporting;Reproductive Health;Research;Resources;Risk;scale up;school district;Schools;Self Efficacy;Sex Behavior;Sex Education;Sexual Health;skills;Societies;South Texas;Statutes and Laws;Students;teen birth;Teenagers;Testing;Texas;theories;Time;Training;unintended pregnancy;Update;uptake;Work;Youth

PROJECT_TITLE: Disseminating Effective Reproductive and Sexual Health Programs

STUDY_SECTION: SIHH

STUDY_SECTION_NAME: Science of Implementation in Health and Healthcare Study Section[SIHH]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

ORG_CITY: ALBUQUERQUE

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR

ORG_STATE: NM

PHR: PROJECT NARRATIVE Abandoned uranium mines, primarily located on tribal land in the southwest United States, are not remediated and continue to degrade heavy metals into the surrounding environment, contaminating the sedimentary dust and ground water with significant concentrations of uranium. Epidemiological data suggests a direct link between inhalation and ingestion of uranium mine dusts with higher incidences of intestinal inflammation and diseases. This proposal aims to define and characterize the mechanisms underlying uranium-induced intestinal dysfunction and long-term consequences in the intestinal epithelia.

PI_NAMEs: IN, JULIE GOEUN (contact)

PROGRAM_OFFICER_NAME: SHREFFLER, CAROL A

PROJECT_TERMS: 3-Dimensional;absorption;Address;Apical;Autophagocytosis;Bacterial Adhesion;Biological;Cell Differentiation process;Cell Line;Cell Lineage;Cell secretion;Cells;Chemical Exposure;Chemical Injury;Chronic;Coculture Techniques;Colitis;Colon;Colorectal Cancer;Communities;cytokine;Disease;Disease Progression;Dust;Endocrine;Enteroendocrine Cell;Environment;epidemiologic data;Epithelial Cells;Epithelium;Exhibits;Exposure to;Functional disorder;Gastrointestinal tract structure;Genetic;Genetic Variation;Goals;Goblet Cells;ground water;gut inflammation;gut microbiota;healing;Heavy Metals;Homeostasis;Hormone secretion;Hormones;Human;human data;Immune;immunological status;In Vitro;in vivo;Incidence;Individual;Inflammatory;Inflammatory Response;Ingestion;Inhalation;Injury;intestinal barrier;Intestinal Diseases;intestinal epithelium;intestinal homeostasis;intestinal injury;Intestines;Invaded;Ligands;Link;Lung;Macrophage;Mediating;Metal exposure;Metals;microbial;microbiota;Minerals;Modeling;Molecular;monolayer;Mucociliary Clearance;Mucous body substance;Mucous Membrane;Organoids;Outcome;particle;Particulate;pathogen;Pathology;Pathway interactions;Penetration;Peptides;Permeability;Predisposition;Prevalence;response;response to injury;Site;Source;Surface;Testing;therapeutic target;Thick;Thinness;tool;Toxic Environmental Substances;transcription factor;transcriptomics;Travel;tribal lands;two-dimensional;United States;Uranium;wasting;Water;well water

PROJECT_TITLE: Heavy metals exposure regulates secretory lineage in intestinal injury

STUDY_SECTION: EDD

STUDY_SECTION_NAME: Environmental Determinants of Disease Study Section [EDD]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Hearing Loss;Neurosciences;Rehabilitation

ORG_CITY: HAMILTON

ORG_COUNTRY: CANADA

ORG_FIPS: CA

ORG_NAME: MCMASTER UNIVERSITY

ORG_STATE: ON

ORG_ZIPCODE: L8S 4K1

PHR: Project Narrative A frequent complaint in older adults is difficulty with speech comprehension, especially in the presence of background noise. Using a high-powered individual difference approach, this project will use neural and behavioral measures to determine successful and unsuccessful adaptation mechanisms. This work aims to discover learnable cognitive strategies for improving speech recognition, and generate biomarkers for successful and harmful adaptations.

PI_NAMEs: BRODBECK, CHRISTIAN  (contact)

PROGRAM_OFFICER_NAME: POREMBA, AMY

PROJECT_TERMS: Acoustics;Affect;age effect;age related changes;Aging;Attenuated;Audiology;Auditory;behavior measurement;behavior observation;Behavioral;behavioral study;Biological Markers;Brain;Cognitive;cognitive ability;Communication;Compensation;Complex;Comprehension;Control Groups;Coping Skills;Data Set;Electroencephalography;Emotional;Ensure;Entropy;experience;Functional Magnetic Resonance Imaging;functional outcomes;Future;Health;Hearing;Hearing Aids;hearing impairment;Hearing Tests;Impairment;improved;Individual;Individual Differences;individual variation;information processing;interest;Laboratories;Language;language comprehension;language processing;large datasets;Learning;lexical;Life;Linguistics;Measures;Methods;millisecond;Modeling;neural;neuroimaging;neuromechanism;Noise;normal hearing;novel;older adult;Perception;Performance;Phonetics;Pisum sativum;Play;predictive signature;Presbycusis;preservation;Process;protective factors;recruit;remediation;Research;Research Personnel;resilience;response;Restaurants;Role;Sample Size;Scheme;Sensory;Short-Term Memory;sound;Speech;speech in noise;Speech Perception;speech processing;speech recognition;Speech Sound;Techniques;Testing;therapy design;Training;Uncertainty;Work;young adult

PROJECT_TITLE: Neural Mechanisms Underlying Linguistic Context Use for Speech Processing in Aging

STUDY_SECTION: LCOM

STUDY_SECTION_NAME: Language and Communication Study Section[LCOM]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: BIRMINGHAM

ORG_NAME: BIRMINGHAM VA MEDICAL CENTER

ORG_STATE: AL

PHR: PROJECT NARRATIVE There is a need to understand the molecular mechanisms responsible for pro-fibrotic responses in idiopathic pulmonary fibrosis. Cell matrix interaction plays a fundamental role in normal and diseased conditions. This proposal is to understand the critical mechanisms that leads to deadly pulmonary fibrosis.

PI_NAMEs: DING, QIANG  (contact)

PROJECT_TERMS: Bleomycin;Cell Communication;Cells;Collagen;crosslink;Data;Development;Disease;driving force;effective therapy;Extracellular Matrix;Extracellular Matrix Proteins;Fibroblasts;fibrogenesis;Fibronectins;fibrotic lung;fibrotic lung disease;Focal Adhesion Kinase 1;Fostering;Gene Expression;Goals;Human;idiopathic pulmonary fibrosis;Impairment;In Vitro;in vivo;insight;Integrin alpha4beta1;Integrins;Invaded;Knockout Mice;Lung;lung development;lung injury;lung repair;Mediator;Messenger RNA;migration;military veteran;Molecular;mRNA Stability;Mus;Myofibroblast;Neurons;Pathogenesis;Pathologic;Patients;Play;Production;Proliferating;protein expression;Pulmonary Fibrosis;Regulation;Regulator Genes;response;Risk Factors;Role;Signal Transduction;Smoking;Structure of parenchyma of lung;System;Testing;TGFB1 gene;TIS11 protein;Veterans;Wild Type Mouse;Wiskott-Aldrich syndrome protein

PROJECT_TITLE: Adhesome signaling in lung injury and repair

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 PULM-T (01)]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Heart Disease;Patient Safety;Social Determinants of Health

ORG_CITY: BOSTON

ORG_DEPT: ADMINISTRATION

ORG_NAME: HARVARD MEDICAL SCHOOL

ORG_STATE: MA

PHR: Project Narrative This project aims to compare the regulatory approval and reimbursement policies, adoption, and outcomes of treatment for 3 cardiovascular condition dyads where introduction/refinements in advanced therapy is disrupting an established therapy in seven countries with vastly different health system organization. Our research will address major unanswered questions by providing crucial insights into how advanced cardiovascular technologies are adopted and used in different countries.

PI_NAMEs: CRAM, PETER M;LANDON, BRUCE E. (contact)

PROGRAM_OFFICER_NAME: MINTZER, KEITH A

PROJECT_TERMS: Abdominal Aortic Aneurysm;Academy;Acute myocardial infarction;Adopted;Adoption;Affect;Aneurysm;aortic valve;aortic valve replacement;Aortic Valve Stenosis;Australia;Benefits and Risks;Canada;cancer surgery;Cardiovascular system;Carotid Arteries;Carotid Endarterectomy;Carotid Stenosis;Carotid stent;Clinical;Code;cohort;comparative;Comparative Study;Consensus;cost;Country;Data;Death Rate;Decision Making;Developed Countries;Development;Diagnosis;Diffuse Pattern;Diffusion;Disadvantaged;Disease;Disparity;Economics;England;Environment;Equity;Failure;Fee-for-Service Plans;Functional disorder;Funding;Guidelines;Health;health care disparity;Health system;Health Technology;Healthcare;Healthcare Systems;Home;hospital readmission;Hospitalization;Hospitals;Income;indexing;Inferior;Infrastructure;Injury;insight;Institute of Medicine (U.S.);Insurance Coverage;interest;International;Israel;Length of Stay;Life Cycle Stages;Life Expectancy;Link;Literature;Medicare;Medicine;member;Methods;Morbidity - disease rate;mortality;multidisciplinary;Netherlands;new technology;novel therapeutics;older adult;Operative Surgical Procedures;Outcome;Paper;Patient Representative;Patient-Focused Outcomes;Patients;payment;peer;Persons;Policies;poor health outcome;Population;population health;Practice Guidelines;Procedures;Process;Process Assessment;programs;public health insurance;Publishing;repaired;Reporting;Research;revascularization;socioeconomic disparity;Socioeconomic Status;Spine surgery;Stem cell transplant;Stents;systems research;Taiwan;Technology;Technology Assessment;technology diffusion;therapy outcome;Time;treatment and outcome;treatment comparison;Treatment outcome;United States Food and Drug Administration

PROJECT_TITLE: Comparing approval, adoption/de-adoption and outcomes for advanced cardiovascular procedures across high-income countries

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 HSS-F (90)]


NIH_SPENDING_CATS: Biotechnology

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE These studies in lampreys, a pivotal vertebrate representative, will yield insight into the basic evolutionary principles of adaptive immune system development and function. The lamprey antibody producing cells will be extensively characterized and their structurally unique antibodies with novel specificities engineered to exploit their diagnostic potential in human cancers.

PI_NAMEs: COOPER, MAX DALE (contact)

PROGRAM_OFFICER_NAME: SINGLETON, KENTNER L

PROJECT_TERMS: 3' Untranslated Regions;5' Untranslated Regions;Adaptive Immune System;adaptive immunity;Adaptor Signaling Protein;Adult;Antibodies;Antibody-Producing Cells;Antigen Receptors;Antigens;Astrocytoma;B-Cell Development;B-Lymphocytes;Basic Science;Biological Assay;Biology;Brain;C-Peptide;Cell Membrane Proteins;Cell surface;Cell Surface Receptors;cell type;Cells;Cellular Immunity;Code;combinatorial;CRISPR/Cas technology;crosslink;CXCR4 gene;Cytidine Deaminase;Cytoplasm;Data;Data Set;Development;Diagnostic;Diagnostic Reagent;Embryo;Engineering;Evolution;feeding;Gene Conversion;Generations;Genes;Genetic;Genomics;Germ Lines;Glioblastoma;Goals;Hagfish;Hematopoietic;Human;IL16 gene;IL17 gene;IL8 gene;IL8RB gene;Immunoglobulin Domain;Immunoglobulin Variable Region;Immunoglobulins;insight;Integral Membrane Protein;Interleukin-16;Introns;ITAM;Jaw;Laboratories;Lampreys;Larva;Left;Leucine-Rich Repeat;link protein;Lymphocyte;Malignant neoplasm of ovary;Malignant Neoplasms;Mass Spectrum Analysis;Mediating;Mediator;model development;Monoclonal Antibodies;monomer;neoplastic cell;novel;novel diagnostics;ovarian neoplasm;Pathway interactions;Pattern;Peptide Signal Sequences;Petromyzon marinus;Phylogeny;Plasma Cells;Polymers;Polysaccharides;Process;programs;Proteins;receptor;receptor expression;Receptor Gene;Research;Signal Induction;Signal Transduction;single-cell RNA sequencing;Source;Specificity;Surface;System;Systems Development;T-Cell Receptor;Tertiary Protein Structure;Therapeutic;Thymus Gland;Tissues;TLR2 gene;tool;transcriptome;translational applications;Translational Research;Transmembrane Domain;Tumor Cell Line;Untranslated RNA;Vertebrates;Work

PROJECT_TITLE: Characterization of Lamprey B cells and Antibodies

STUDY_SECTION: CMIA

STUDY_SECTION_NAME: Cellular and Molecular Immunology - A Study Section[CMIA]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Genetics;Neuroblastoma;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: LA JOLLA

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

ORG_STATE: CA

PHR: PROJECT NARRATIVE While clinical development of HDAC inhibitors for oncology has been largely unsuccessful, we recently discovered a synthetic lethal relationship between HDAC1 and HDAC2 that should offer a greater window for therapeutic development. Based on our preliminary data that members of the HDAC1/2-containing NuRD chromatin remodeler complex are required for the survival of cancers impacted by HDAC1/2 synthetic lethality, we propose to (i) determine the mechanistic basis underlying NuRD vulnerabilities in these cancers and (ii) develop small-molecule modulators of NuRD function that target cancer-specific NuRD vulnerabilities.

PI_NAMEs: ERB, MICHAEL A (contact)

PROGRAM_OFFICER_NAME: VENKATACHALAM, SUNDARESAN

PROJECT_TERMS: Amines;anti-cancer therapeutic;Antineoplastic Agents;Binding;cancer cell;cancer subtypes;cancer survival;cancer type;Cell Survival;cell type;Cells;Chemicals;Chromatin;chromatin remodeling;Chromatin Structure;Chromosome Deletion;Clinic;Clinical;clinical development;Complex;CRISPR/Cas technology;Data;Deacetylation;Dependence;design;Dissociation;Drug Targeting;Enzymes;Excision;experimental study;fitness;Genes;Genetic;Genetic Transcription;HDAC1 gene;HDAC2 gene;Histone Deacetylase;Histone Deacetylase Inhibitor;In Vitro;in vivo;inhibitor;Ligands;Lysine;Malignant Neoplasms;Mediating;member;Modernization;Multiple Myeloma;Nature;Neuroblastoma;neuroblastoma cell;new therapeutic target;novel;novel therapeutics;Nucleosomes;Oncology;Output;paralogous gene;Pharmaceutical Preparations;pharmacologic;Proteins;Proteomics;Recurrence;RNA Interference;Side;small molecule;Somatic Cell;Structure;Therapeutic;therapeutic development;tool;translational potential;tumor;Work;Zinc

PROJECT_TITLE: Cancer-specific dependencies within the NuRD chromatin remodeler complex: new targets and chemical tools

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 DMPC-J (90)]


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Intellectual and Developmental Disabilities (IDD);Neurosciences;Orphan Drug;Pediatric;Prevention;Rare Diseases

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: NARRATIVE – Significant knowledge gaps remain in our understanding of succinic semialdehyde dehydrogenase deficiency (SSADHD, a defect of GABA metabolism), including the clinical, neurophysiological, and biochemical course of the disease. The proposed continuation of the SSADHD Natural History study, started 4 years ago, will expand the longitudinal perspective needed to better predict the natural course of the disease and lay the foundation for the addition of SSADHD to existing newborn screening panels.

PI_NAMEs: PEARL, PHILLIP LAWRENCE (contact)

PROGRAM_OFFICER_NAME: PARISI, MELISSA

PROJECT_TERMS: Address;Adult;Age;age related changes;base;behavioral impairment;Biochemical;Biochemical Markers;Biological Markers;Blood;Boston;Brain;Cerebrovascular Circulation;Clinical;Clinical Data;Clinical Trials;Cohort Studies;Collection;Communication impairment;Control Groups;Data;Data Analyses;Development;Diagnostic;Disease;Disease Marker;disease prognosis;Disease Progression;Early Diagnosis;efficacy evaluation;Enrollment;Epilepsy;Evaluation;Family;follow-up;Foundations;Functional Magnetic Resonance Imaging;Funding;Future;gamma-Aminobutyric Acid;Genes;Genetic Diseases;Germany;Hereditary Disease;Homeostasis;Impaired cognition;Impairment;improved;indexing;Individual;insight;Institution;Intake;International;Knowledge;Laboratories;Magnetic Resonance Spectroscopy;Measurement;Measures;Messenger RNA;Metabolic;Metabolic Diseases;Metabolism;Methods;Molecular;Monitor;Motor;motor impairment;Mutation;Natural History;Neonatal Screening;Neurologic;neurophysiology;Neuropsychology;neurotransmission;Neurotransmitters;Norway;novel;Older Population;Participant;participant enrollment;Pathogenicity;patient advocacy group;Patients;Pediatric Hospitals;Plasma;Prognosis;prognostic value;Rare Diseases;rare genetic disorder;recruit;Research;Research Design;Rest;screening;screening panel;Seizures;Severities;Severity of illness;sex;Site;sleep regulation;Spain;Specialist;standard of care;Standardization;Statistical Data Interpretation;success;Succinate-semialdehyde dehydrogenase deficiency;Teenagers;Testing;Therapeutic;Therapeutic Trials;Time;tool;Transcranial magnetic stimulation;Urine;Validation;Visit;working group;γ-hydroxybutyrate

PROJECT_TITLE: Natural History of Succinic Semialdehyde Dehydrogenase Deficiency (SSADHD), a Heritable Disorder of GABA Metabolism

STUDY_SECTION: TAG

STUDY_SECTION_NAME: Therapeutic Approaches to Genetic Diseases Study Section[TAG]


NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Obesity;Clinical Research;Cost Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Microbiome;Nutrition;Obesity;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: PULLMAN

ORG_NAME: WASHINGTON STATE UNIVERSITY

ORG_STATE: WA

PHR: PROJECT NARRATIVE Childhood obesity is a pervasive public health threat, inequities in social determinants of health create a context of stress that exacerbates childhood obesity, and novel outdoor preschool models offer innovative opportunities for: 1) obesity prevention, and 2) biological resilience to obesogenic social determinants of health. The gut microbiome plays an influential role in the intersection of stress and childhood obesity and is directly influenced by environmental factors such as outdoor time. Thus, we propose a prospective longitudinal natural experiment to examine the effect of a novel outdoor preschool model on gut microbiome characteristics, physiological stress, and the association with obesity in early childhood.

PI_NAMEs: FYFE-JOHNSON, AMBER  (contact)

PROGRAM_OFFICER_NAME: POOL, LINDSAY REGINA

PROJECT_TERMS: 5 year old;Adult;Affect;Area;Behavior;Biological;Biological Assay;Biological Markers;Body mass index;Budgets;built environment;Cardiovascular system;Characteristics;Child;Childhood;Chronic stress;Communities;contextual factors;Cost Effectiveness Analysis;Cost-Benefit Analysis;Country;critical period;Cross-Sectional Studies;early childhood;Economics;education access;Educational Curriculum;Effectiveness;Eligibility Determination;Enrollment;Environmental Risk Factor;epidemiology study;Exhibits;experimental study;Exposure to;Family;Gastrointestinal tract structure;Green space;gut microbiome;Health;Health Status Indicators;Household;Human;Hydrocortisone;improved;Income;indexing;Individual;Individual Adjustment;Inequity;Influentials;innovation;Intervention;Investments;Learning;Life;life span;Link;Location;low socioeconomic status;Mediation;Mediator;metropolitan;Microbe;microbial;microorganism;Modeling;mortality;National Heart, Lung, and Blood Institute;Natural experiment;Nature;Neighborhoods;novel;Nursery Schools;Obesity;Obesity Epidemic;obesity in children;obesity management;obesity prevention;obesogenic;Outcome;Outcome Measure;Overweight;Performance;Persons;PhenX Toolkit;Physical activity;Physiological;Play;Policies;Population;prevent;Prevention;primary outcome;programs;promote resilience;prospective;Protocols documentation;psychologic;Public Health;Recording of previous events;recruit;Research;resilience;Risk Factors;Role;Sample Size;Sampling;secondary outcome;social;social health determinants;social structure;socioeconomic disadvantage;Socioeconomic Status;Soil;Spottings;stool sample;Stress;stress reduction;Students;Testing;Time;Trees;urban setting;Visit;Waiting Lists

PROJECT_TITLE: Childhood Obesity: the role of the gut Microbiome, outdoor Time, and Stress(COMETS)

STUDY_SECTION: SEDH

STUDY_SECTION_NAME: Social and Environmental Determinants of Health Study Section[SEDH]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Neurosciences;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: NEW YORK

ORG_DEPT: PSYCHIATRY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: PROJECT NARRATIVE The proposed project is relevant to public health because it uses a randomized clinical trial to experimentally test for perinatal biological embedding of a supportive perinatal intervention in the context of adversity. The results will contribute toward the development of non-invasive, proximal DNA methylation indicators of perinatal interventions’ effects on offspring. Thus, the proposed research aligns with the part of NICHD’s mission that seeks to ensure that all children have the chance to fulfill their potential to live healthy and productive lives free from disease or disability.

PI_NAMEs: O'DONNELL, KIERAN J;SCORZA BIANCHOTTI, PAMELA LORRAINE (contact)

PROGRAM_OFFICER_NAME: MACHLIN, LAURA STONER

PROJECT_TERMS: Acceleration;Adolescent Development;age acceleration;Age Months;Binding;Biological;Biological Markers;Biological Testing;Biology;Birth;Black race;Blood specimen;Brain;Cell Physiology;Cells;Child;Child Development;Childhood;Chromatin;Clinical Research;cost;Cytosine;Data;Development;disability;Disease;Disparity;DNA;DNA Methylation;early experience;Early Intervention;Economics;effective intervention;Epigenetic age;epigenetic aging;epigenetic clock;Evaluation;evidence base;experience;Family Nursing;Funding;Gene Expression;Genetic;Genetic Variation;Genome;genome sequencing;Glucocorticoids;Growth;Health;Health behavior;health inequalities;Hippocampus;Home environment;Home visitation;Human;improved;Individual;Inequity;infancy;Infant;Infant Development;Inflammation;insight;Intervention;intervention effect;intervention refinement;Life;Life Expectancy;Magnetic Resonance Imaging;Manuals;Measures;Mediator;Methodology;methyl group;methylation biomarker;methylome;minimally invasive;Mission;National Institute of Child Health and Human Development;Neonatal;neurodevelopment;novel;Nuclear;Nurses;offspring;Outcome;Oxidative Stress;parenting intervention;people of color;Perinatal;perinatal intervention;Peripheral;Ploidies;Policies;Population;Population Intervention;postnatal;Postpartum Period;potential biomarker;Poverty;Pregnancy;pregnant;prenatal health;primary endpoint;Productivity;programs;prospective test;Public Health;Race;racial disparity;Randomized;randomized trial;randomized, clinical trials;Reduce health disparities;Research;Research Personnel;Risk;Rodent;Site;Social support;Socioeconomic Status;stem cell biology;stem cells;Structure;Testing;Tissues;transcription factor;treatment as usual;Treatment Efficacy;underserved community;Variant;whole genome;Woman

PROJECT_TITLE: A prospective test of biological embedding within a randomized trial of the Nurse Family Partnership intervention: DNA methylome change over infancy and relevance for child development

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BP-P (02)]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

ORG_CITY: SEATTLE

ORG_NAME: ALLEN INSTITUTE

PHR: Project Narrative Long-range projections of neuronal types underlie the structure of neuronal circuits and constrain computations, but these relationship between projections and neuronal types remain largely unclear. We will unravel the relationship between gene expression and projections in the mouse corticothalamic circuit by combining state-of-the-art high-throughput in situ sequencing-based neuroanatomical techniques and robust meta-analysis. We will build a comprehensive spatiotemporal map of the corticothalamic projections in the context of neuronal gene expression and link our data with rich external reference single-cell RNAseq data to extract gene-projection relationship with unprecedented details.

PI_NAMEs: CHEN, XIAOYIN  (contact)

PROGRAM_OFFICER_NAME: LEINWAND, SARAH GOLDBERG

PROJECT_TERMS: Adult;anatomical tracing;Area;Bar Codes;Base Sequence;Brain;Brain region;Cell Adhesion Molecules;cell type;Cells;Cerebral cortex;Complex;Computer Models;cortex mapping;course development;Data;Data Set;Development;Foundations;Future;Gene Expression;Gene Expression Profile;Genes;Genetic Transcription;In Situ;in situ sequencing;insight;Link;Maps;Meta-Analysis;Methods;Modality;Modeling;Mus;Nature;Neuroanatomy;neuronal circuitry;Neurons;Pattern;Population;Positioning Attribute;postnatal;programs;Property;Publishing;Rabies virus;reconstruction;Resolution;Resources;RNA;Role;Sampling;Sindbis Virus;single-cell RNA sequencing;spatiotemporal;Specific qualifier value;Structure;Techniques;Thalamic structure;Time;transcription factor;transcriptomics;Variant;Work

PROJECT_TITLE: Revealing the transcriptional basis of corticothalamic projections using in situ sequence-based neuroanatomy

STUDY_SECTION: NDPR

STUDY_SECTION_NAME: Neurodifferentiation, Plasticity, Regeneration and Rhythmicity Study Section[NDPR]


ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE In this project, a new class of biological reporters will be developed and deployed to identify key bottlenecks in the translation of CAR chimeric antigen receptor (CAR) T-cell therapy, an emerging therapeutic approach to cancer treatment. This work will reveal new avenues to improve the overall general performance and durability of CAR T cells, by enabling researchers to easily view the history of calcium signaling in these cells. The imaging probes leverage state-of-the-art bioluminescent and fluorescent proteins, which naturally emit and transform light, to build probes that non-invasively record biochemical activities in living cells.

PI_NAMEs: PRESCHER, JENNIFER ;SHANER, NATHAN CHRISTOPHER (contact);WANG, YINGXIAO

PROGRAM_OFFICER_NAME: AMIN, ANOWARUL

PROJECT_TERMS: Activities of Daily Living;Adopted;Adoption;Antigens;Benchmarking;Biochemical;Biological;Biological Availability;Bioluminescence;blood treatment;Calcium;calcium indicator;Calcium Signaling;Cancer Relapse;cancer therapy;CAR T cell therapy;CD8-Positive T-Lymphocytes;Cell model;Cell Physiology;cell type;Cells;chimeric antigen receptor;chimeric antigen receptor T cells;Chimeric Proteins;Clinical;Clinical Trials;Clone Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Coculture Techniques;Coupled;design;disease model;DNA Sequence Alteration;Engineering;Event;exhaust;exhaustion;experimental study;Exposure to;Family;Fluorescence;Fluorescence Resonance Energy Transfer;Fluorescence-Activated Cell Sorting;Functional disorder;Future;Habitats;Hematopoietic Neoplasms;Image;Imaging Device;imaging platform;imaging probe;Immunotherapy;improved;In Vitro;in vivo;Individual;insight;interest;Kinetics;Knock-out;leukemia;Libraries;Light;light emission;Luciferases;luciferin;Malignant Neoplasms;Measures;Methods;Microscopy;Modeling;Monitor;Mus;neoplastic cell;Neurosciences;Optical reporter;Optics;Oranges;Organism;Performance;Population;Proteins;Reagent;Recording of previous events;Reporter;Reporting;Research Personnel;Resistance;Resolution;Role;sensor;Signal Transduction;small molecule;Solid Neoplasm;Source;Specificity;subcutaneous;success;T memory cell;T-Cell Activation;T-Lymphocyte;TCR Activation;Technology;Therapeutic;Therapeutic Agents;therapeutic effectiveness;Therapeutic Intervention;therapeutically effective;Time;tool;Translations;tumor;tumor microenvironment;Visualization;Work;Xenograft procedure

PROJECT_TITLE: New tools for quantitative non-invasive recording of biochemical signals

STUDY_SECTION: CMT

STUDY_SECTION_NAME: Cellular and Molecular Technologies Study Section[CMT]


NIH_SPENDING_CATS: Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Social Determinants of Health

ORG_NAME: FRED HUTCHINSON CANCER CENTER

PHR: Project Narrative While the Affordable Care Act (ACA) improved commercial insurance access for vulnerable patients – i.e., financially fragile individuals, those living in socioeconomically disadvantaged neighborhoods, or of minority race – little is known about the clinical and financial experiences of vulnerable commercially insured cancer patients in the post-ACA era. In this study, we will leverage a unique data asset that combines cancer registry, commercial insurance enrollment and claims, credit reports, and bankruptcy records to characterize out of pocket cost exposure and its relationship to disparities in care and adverse clinical and financial outcomes among commercially insured cancer patients following implementation of the ACA reforms, with particular emphasis on medically and financially vulnerable patients.

PI_NAMEs: RAMSEY, SCOTT D. (contact)

PROGRAM_OFFICER_NAME: CROSWELL, JENNIFER

PROJECT_TERMS: Accident and Emergency department;Address;Admission activity;Adopted;adverse outcome;Affordable Care Act;Age;American;Area;Bankruptcy;Blue Cross;Blue Shield;cancer care;cancer health disparity;Cancer Patient;Caring;Characteristics;Chronic;Clinical;Collaborations;Collection;Communities;comorbidity;cost;Data;Data Files;data registry;Databases;deprivation;design;Diagnosis;Disparity;disparity reduction;Eligibility Determination;end of life care;Enrollment;Ethnic Origin;experience;Family;Financial Hardship;financial toxicity;Foreclosure;Health;health care disparity;Health Insurance;Health Services Accessibility;high risk;Hospital Departments;Improve Access;improved;Income;indexing;Individual;Insurance;Insurance Carriers;Link;Malignant Neoplasms;Measurement;Measures;Medicaid;Medicaid eligibility;Medical;neighborhood disadvantage;Neighborhoods;neoplasm registry;Newly Diagnosed;novel;Oncology;Outcome;Patients;payment;Performance;Persons;Policies;Policy Maker;Population;Quality of Care;racial minority;Recommendation;Records;Reporting;Research;Resources;Risk;socioeconomic disadvantage;Surveys;Systemic Therapy;Time;treatment and outcome;treatment disparity;trend;Uninsured Medical Expense;Update;Vulnerable Populations;Washington

PROJECT_TITLE: Disparities in Financial and Clinical Outcomes among Commercially-Insured Cancer Patients following the Affordable Care Act

STUDY_SECTION: ODHS

STUDY_SECTION_NAME: Organization and Delivery of Health Services Study Section[ODHS]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Behavioral and Social Science;Burden of Illness;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Immunotherapy;Inflammatory Bowel Disease;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it focuses on understanding disease course and treatment outcomes in Hispanic patients with inflammatory bowel diseases, an understudied population with high disease burden. By simultaneously examining biological and multi-dimensional social and structural determinants of health in Hispanic patients with IBD and their contribution to adverse disease and treatment outcomes, we will directly inform management of these health disparity population. The proposed research is relevant to the part of the NIH’s mission that pertains to enhancing health, reducing illness and disability.

PI_NAMEs: SINGH, SIDDHARTH  (contact)

PROGRAM_OFFICER_NAME: UNALP-ARIDA, AYNUR

PROJECT_TERMS: antagonist;Area;biobank;Biological;Biological Products;burden of illness;California;Censuses;Clinical;clinical care;Clinical Informatics;clinical prognostic;Clinical Trials;cohort;Communities;comparative effectiveness;Comparative Effectiveness Research;comparative safety;compare effectiveness;cost effective;Crohn's disease;Data;data warehouse;Databases;deprivation;Dimensions;disability;Disease;Disease Outcome;Education;Electronic Health Record;Epidemiology;epidemiology study;Evaluation;evidence base;experience;Family;food insecurity;Gene Expression;Genetic;Genetic Research;Goals;Guidelines;Health;health care availability;health care service utilization;health determinants;health disparity populations;health management;Health Policy;Health system;Healthcare;high risk;Hispanic;Hispanic Populations;HLA-DQA1;Hospitalization;Immigration;Immune Targeting;Immunomodulators;immunomodulatory therapies;improved;Incidence;indexing;Infection;Inferior;Inflammatory Bowel Diseases;Infrastructure;innovation;insurance claims;Intestines;Knowledge;Language;Life Style;Measures;Medical center;Methodology;Mission;Multicenter Studies;Natural History;Not Hispanic or Latino;novel;oncostatin M;Operative Surgical Procedures;Oral;outcome prediction;patient registry;Patients;Pattern;Population;Predictive Factor;Prevalence;Principal Investigator;Prognostic Factor;prospective;Prospective, cohort study;Public Health;Questionnaires;Research;Research Methodology;Research Personnel;response;Risk Factors;Safety;screening;small molecule inhibitor;social;social determinants;structural determinants;structural health determinants;Testing;Therapeutic immunosuppression;Tissues;TNF gene;tool;transcriptomics;Transportation;Treatment Effectiveness;Treatment outcome;treatment pattern;treatment response;Ulcerative Colitis;Underrepresented Minority;United States;United States National Institutes of Health;uptake;Variant;Vulnerable Populations

PROJECT_TITLE: Comparative effectiveness research in Hispanic patients with inflammatory bowel diseases

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 HSS-W (02)]


NIH_SPENDING_CATS: Neurosciences;Nutrition;Obesity

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative Proper regulations of food intake and body weight are governed by neurons in the central nervous system. We have recently discovered a novel population of neurons in the mouse hindbrain that potently drive feeding. This application will determine how these neurons function to promote feeding and weight gain.

PI_NAMEs: XU, ALLISON W (contact)

PROGRAM_OFFICER_NAME: COOKE, BRAD

PROJECT_TERMS: Ablation;Acute;Adult;Agonist;Anorexia;Appetite Depressants;Appetite Stimulants;Area;ART protein;Body Weight;Body Weight decreased;Brain Stem;Cells;Central Nervous System;Cephalic;Compensation;Data Analyses;Diphtheria Toxin;Dose;Eating;Electrophysiology (science);energy balance;experimental study;Fasting;feeding;Food deprivation (experimental);Food Intake Regulation;gamma-Aminobutyric Acid;Genetic;ghrelin;ghrelin receptor;Glucose;Glutamates;Goals;hindbrain;Human;Hyperphagia;Hypothalamic structure;Infusion procedures;Injections;Insulin;Insulin Receptor;integration site;Knowledge;Life;Maintenance;Mediating;Metabolic;Metabolic hormone;Metabolism;Methods;Mus;neural;neuronal circuitry;Neurons;novel;Nucleus solitarius;Obesity;Opsin;optogenetics;Photophobia;Population;Prevalence;protein expression;receptor;Regulation;Rodent;SHU 9119;Signal Transduction;single-cell RNA sequencing;sound;Structure of area postrema;Structure of nucleus infundibularis hypothalami;Surface;System;Time;Weight Gain;α-Melanocyte stimulating hormone

PROJECT_TITLE: Orexigenic AgRP neurons in the brainstem

STUDY_SECTION: POMD

STUDY_SECTION_NAME: Pathophysiology of Obesity and Metabolic Disease Study Section[POMD]


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Women's Health Research

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: NARRATIVE We previously reported that the viability of some breast cancers depends on histone deacetylase 6 (HDAC6). In this grant proposal, our ultimate goal is to define the clinical space for HDAC6 inhibitors in breast cancers (aim 1) and understand the molecular mechanism that mediates the anticancer activity of HDAC6i/s to use this information to improve HDAC6-based breast cancer regimens. We will pursue these objectives by Investigating the mechanisms of resistance to HDAC6i/s (aim 2).

PI_NAMEs: SILVA, JOSE M (contact);YU, JIYANG

PROJECT_TERMS: Acetylation;Acetyltransferase;anticancer activity;Applications Grants;Automobile Driving;base;Biological Markers;Breast Cancer Cell;Breast Cancer therapy;Breast Cancer Treatment;c-myc Genes;cancer cell;cancer type;Catalogs;Cell Line;Cell Survival;Cells;CLIA certified;Clinic;Clinical;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;combinatorial;Data;Deacetylation;design;Development;Disease;Down-Regulation;EP300 gene;Epigenetic Process;Equilibrium;ERBB2 gene;Exposure to;Genes;Genetic;genetic approach;Genomics;Goals;HDAC6 gene;Histone Deacetylase Inhibitor;Human;improved;In Vitro;in vivo;inhibitor;Link;Malignant Breast Neoplasm;Malignant Neoplasms;Manuscripts;Mediating;mimetics;Molecular;mouse model;multicatalytic endopeptidase complex;mutant;Nature;Oncogenes;Organoids;Paclitaxel;Pathway Analysis;Pathway interactions;Patients;Post-Translational Protein Processing;prevent;protein structure;Proteins;Regimen;Regulation;Reporting;Research;Resistance;resistance mechanism;responders and non-responders;response;Role;Sampling;single-cell RNA sequencing;Site;small molecule inhibitor;Specificity;standard of care;success;Systemic Therapy;targeted treatment;Testing;Therapeutic;Tissue Sample;transcriptomics;Translations;tumor;tumor microenvironment;tumorigenesis;Xenograft procedure

PROJECT_TITLE: Investigating the Molecular Determinants Driving Response and Resistance to HDAC6 Targeted Therapy in Breast Cancer

STUDY_SECTION: MCTB

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics B Study Section[MCTB]


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Diabetes;Nutrition;Physical Activity;Prevention

ORG_CITY: TEMPE

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

ORG_STATE: AZ

PHR: Project Narrative This mobile health (mHealth) pilot study will develop an intervention to maintain reductions in evening sedentary screen time (eSST) over 12 months using a novel habit formation strategy among a nationally-recruited sample of adults at-risk for type 2 diabetes. Our intervention combines theory- and evidence-based approaches for addressing individual barriers to habit formation, which is a critical component of behavior change maintenance. This (ORBIT Model) Phase II pilot study will provide new insights into the relationships between maintained reductions in eSST and metabolic health, an mHealth solution for reducing eSST that can be scaled through the use of several commercially available screen time monitoring tools, and the necessary information to scale-up the StandUPTV application into a Phase III, fully powered randomized clinical trial to test the impact of reducing eSST on diabetes and cardiovascular disease risk in a national sample.

PI_NAMEs: STECHER, CHAD DANIEL (contact)

PROGRAM_OFFICER_NAME: CENTER, MAUREEN MONAGHAN

PROJECT_TERMS: acceptability and feasibility;Address;Adult;American;arm;awake;Awareness;Behavior;behavior change;Behavioral;Behavioral Medicine;Benchmarking;cardiometabolism;Cardiovascular Diseases;cardiovascular disorder risk;clinical biomarkers;Clinical Trials;Coffee;Cues;Data;Diabetes Mellitus;diabetes risk;Diet;discounting;disorder risk;Education;Effectiveness;Effectiveness of Interventions;effectiveness outcome;efficacy testing;efficacy trial;Energy Metabolism;Enrollment;evidence base;Feasibility Studies;feasibility trial;financial incentive;Fostering;Foundations;glucose metabolism;Habits;Health;Health behavior;Hour;improved;Individual;insight;Intervention;intervention refinement;Knowledge;Maintenance;Mediator;medication compliance;Meditation;Metabolic;Methods;mHealth;mhealth interventions;mindfulness meditation;Modeling;Monitor;Motivation;Neurologic Process;Non-Insulin-Dependent Diabetes Mellitus;Notification;novel;Outcome;Outcome Assessment;Participant;Perception;Performance;Phase;phase II trial;phase III trial;Physical activity;Pilot Projects;pilot trial;population health;Positioning Attribute;post intervention;programs;Randomized;randomized, clinical trials;Recommendation;recruit;retention rate;Risk;Role;Sampling;scale up;Science;sedentary;Signal Transduction;Sleep;smoking cessation;social media;Societies;Stream;Technical Expertise;technological innovation;Technology;Television;Testing;theories;therapy development;Time;tool;tv watching;Unconscious State;United States National Institutes of Health;Walking;Work

PROJECT_TITLE: StandUPTV Habits: Feasibility trial for maintaining reductions in sedentary screen time

STUDY_SECTION: LCBH

STUDY_SECTION_NAME: Lifestyle Change and Behavioral Health Study Section[LCBH]


NIH_SPENDING_CATS: Aging;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Infectious Diseases;Lung;Orphan Drug;Precision Medicine;Rare Diseases

ORG_CITY: PORTLAND

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE Chronic Mycobacterium avium complex (MAC) pulmonary disease is an increasingly common orphan disease that causes progressive disability in older adults. Diagnosis is challenging and often delayed, and there is a tremendous unmet therapeutic need. We seek to define immunologic and transcriptomic signatures of MAC pulmonary disease that could ultimately be used to improve diagnosis, clinical management, and design of clinical trials of new and repurposed therapeutics.

PI_NAMEs: LEWINSOHN, DAVID M.;MCWEENEY, SHANNON K.;WINTHROP, KEVIN LORING (contact)

PROGRAM_OFFICER_NAME: LACOURCIERE, KAREN A

PROJECT_TERMS: Acid Fast Bacillae Staining Method;Acute;Affect;American;anti-microbial drug;Anti-Tumor Necrosis Factor Therapy;Antibiotics;antimicrobial;biobank;Biological;Biological Markers;Biological Response Modifier Therapy;Blood;burden of illness;CD8B1 gene;Chest;Chronic;Clinic;Clinical;Clinical Data;Clinical Management;Clinical Trials Design;Clinical Trials Network;cohort;Collaborations;Communicable Diseases;Coupled;cytokine;Cytometry;Data;Decision Making;Development;Diagnosis;Diagnostic;disability;Disease;Disease Progression;Elderly;electronic patient reported outcomes;Enrollment;Evaluation;experience;Exposure to;Feasibility Studies;Genes;health related quality of life;Host Defense;human data;Immune;Immune response;Immunologic Stimulation;Immunologic Tests;Immunologics;improved;Incidence;Individual;Infection;Innate Immune Response;Interferon Type II;Interleukin-12;Knowledge;Literature;Longitudinal Studies;Lung;Lung Diseases;Lung infections;Monitor;Mucous Membrane;mycobacterial;Mycobacterium avium Complex;Mycobacterium Infections;Mycobacterium tuberculosis;Network Infrastructure;next generation;non-tuberculosis mycobacteria;novel;older adult;older patient;Organism;Outcome Measure;participant enrollment;pathogen;Pathogenesis;patient subsets;Patients;Pattern;Peripheral;Peripheral Blood Mononuclear Cell;Pharmacotherapy;Phenotype;Population;population based;Pragmatic clinical trial;Prediction of Response to Therapy;predictive marker;Progressive Disease;prospective;Radiation;radiological imaging;Rare Diseases;Recommendation;Recording of previous events;Recurrence;Recurrent disease;Reporting;Residual Neoplasm;response;RNA;Role;Sampling;Scanning;Site;Societies;Soil;Sputum;symptomatic improvement;Symptoms;T-Lymphocyte;Therapeutic;Time;TNF gene;transcriptome;transcriptome sequencing;transcriptomic profiling;transcriptomics;treatment guidelines;treatment response;Tuberculosis;Virus Diseases;Water;Whole Blood;Woman;Work;X-Ray Computed Tomography

PROJECT_TITLE: Mycobacterium avium complex pulmonary infection: immunologic and transcriptomic signatures of disease and treatment response

STUDY_SECTION: EDIT

STUDY_SECTION_NAME: Etiology, Diagnostic, Intervention and Treatment of Infectious Diseases Study Section[EDIT]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Breast Cancer;Cancer;Genetics;Machine Learning and Artificial Intelligence;Women's Health Research

ORG_CITY: BALTIMORE

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Metastasis is the main cause of cancer mortality, yet the development of treatments directly inhibiting metastasis is still an unmet clinical need. This project aims to identify chemotherapeutic drugs using engineered biomimetic tumor invasion models and to evaluate therapeutic feasibility of inhibiting the target genes involved in breast cancer dissemination to suppress cancer invasion. This study has implications for the preclinical screening of anti-cancer drugs, for characterizing subtypes of breast cancers, and will increase our understanding of the molecular mechanisms of breast cancer invasiveness.

PI_NAMEs: AHN, EUN HYUN  (contact);KIM, DEOK-HO

PROGRAM_OFFICER_NAME: MARQUEZ, GUILLERMO

PROJECT_TERMS: 3-Dimensional;Anisotropy;Antineoplastic Agents;Antitumor Drug Screening Assays;Attenuated;Biological Assay;Biomimetics;Breast Cancer Cell;Breast Cancer cell line;cancer cell;Cancer Cluster;Cancer Etiology;cancer invasiveness;Cancer Patient;Cell Culture Techniques;cell growth;cell motility;Cell Proliferation;Cells;cellular imaging;Cellular Morphology;Chemoresistance;chemotherapeutic agent;chemotherapy;Clinical;clinically relevant;Collagen;Collagen Fiber;Collagen Fibril;CYP1A1 gene;CYP1A2 gene;CYP1B1 gene;Cytochrome P450;Development;differential expression;Dimensions;drug candidate;drug development;drug testing;Drug usage;electric impedance;Electrodes;Engineering;Exposure to;Extracellular Matrix;Family;Fiber;Genes;Genomics;Goals;Growth;Human;Hydrogels;Image;Image Analysis;in vivo;inhibitor;inhibitor therapy;Invaded;Ions;live cell microscopy;Machine Learning;machine learning pipeline;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Neoplasms;Microscopy;migration;mimetics;Modeling;Molecular;Molecular Biology;Morphology;mortality;Motility;nanopattern;Neoplasm Metastasis;neoplastic cell;Oncology;Organoids;patient derived xenograft model;Patient-derived xenograft models of breast cancer;Pattern;Penetration;Permeability;Pharmaceutical Preparations;pharmacologic;Pharmacology;Phenotype;Play;Population;pre-clinical;Preclinical Testing;Prognosis;Proliferating;protein expression;Proteins;Radial;Reactive Oxygen Species;Resistance;response;Role;screening;Side;small hairpin RNA;Subgroup;Therapeutic;therapy development;therapy resistant;three-dimensional modeling;Time;Tissue Engineering;transcriptome sequencing;tumor;Tumor Cell Invasion;Up-Regulation

PROJECT_TITLE: Engineered biomimetic collective cancer invasion models for screening chemotherapeutic agents

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]


NIH_SPENDING_CATS: Neurosciences

ORG_CITY: Los Angeles

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: PROJECT NARRATIVE Our ability to detect and discriminate quiet sounds depends on a mechanical amplification process that is mediated by the cochlea’s sensory cells. The goal of this project is to determine whether these cells can amplify responses to high-frequency sounds by rapidly changing length and generating force, or if alternative mechanisms are involved, such as slow or sustained changes in cell length that modulate how the surrounding structures vibrate. The knowledge gained will clarify how healthy ears work and what is missing in impaired ears, and will inform future efforts to rehabilitate and restore hearing.

PI_NAMEs: DEWEY, JAMES BRADEN (contact)

PROGRAM_OFFICER_NAME: FREEMAN, NANCY

PROJECT_TERMS: Acoustics;Affect;Apical;Attenuated;base;Basilar Membrane;bone;cell injury;cell motility;Cells;cellular transduction;Cessation of life;Characteristics;Cochlea;Data;design;Ear;Environment;Frequencies;Functional Regeneration;Future;Generations;Geometry;Goals;Hearing;hearing impairment;hearing restoration;Impairment;In Vitro;in vivo;insight;Knowledge;Length;Location;Measurement;Measures;Mechanics;mechanotransduction;Mediating;Membrane Potentials;Motility;Motion;Motor;Mus;mutant;normal hearing;novel;Optical Coherence Tomography;Organ of Corti;Outer Hair Cells;Pattern;Pharmaceutical Preparations;Process;Property;Proteins;rat Pres protein;Rehabilitation therapy;response;Role;round window;Sensory;Shapes;Site;sound;sound frequency;Source;Structure;Testing;Variant;vibration;Visualization;voltage;Work

PROJECT_TITLE: Mechanisms of amplification and nonlinearity in the mouse cochlea

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cannabidiol Research;Cannabinoid Research;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Mental Health;Natural Products;Prevention;Substance Misuse;Therapeutic Cannabinoid Research;Tobacco;Tobacco Smoke and Health

ORG_CITY: MINNEAPOLIS

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Narrative Stress is one of the most commonly reported precipitants of tobacco craving and relapse. Tobacco withdrawal is associated with escalation of negative affect symptoms; our research has found multiple stress-related physiological and hormonal alterations during withdrawal that predict relapse. Modifying these stress-related biobehavioral changes may prove useful in reducing effects of stress, especially during withdrawal. By establishing how acute doses of cannabidiol modify responses to stress and by examining moderating effects of cannabidiol on stress response during nicotine withdrawal, this study will provide novel results that could set the stage for subsequent studies to examine how cannabidiol how CBD impacts both stress response and tobacco addiction. Addressing stress-related increases in craving, withdrawal, and relapse would aid tobacco cessation efforts and reduce relapse rates contributing to reducing tobacco’s devastating health effects.

PI_NAMEs: AL'ABSI, MUSTAFA  (contact);LEE, DUSTIN CLARK

PROGRAM_OFFICER_NAME: KAUTZ, MARY A

PROJECT_TERMS: absorption;abuse liability;Acute;acute stress;Address;Affective;Anti-Anxiety Agents;Anxiety;Attention;Attenuated;Behavioral;biobehavior;Biochemical;biological adaptation to stress;Blood;Cannabidiol;Cannabis;Cardiovascular system;Clinic Visits;craving;Data;Dose;Double-Blind Method;emotion regulation;Epidiolex;Exposure to;Formulation;Funding;Health;Hormonal;Hormonal Change;Hour;Hydrocortisone;Hypothalamic structure;Link;marijuana user;Marketing;Measures;men;Moods;negative affect;Nicotine Withdrawal;non-smoker;novel;Opioid;Oral;Participant;Patient Self-Report;pharmacologic;Physiological;phytocannabinoid;Pituitary Gland;Placebos;Procedures;psychobiologic;psychopharmacologic;Public Health;Randomized;Recovery;Regulation;Relapse;relapse prediction;Reporting;Reproducibility;Research;response;Rest;Sex Differences;Site;Smoker;Smoking;Smoking Cessation Intervention;Stress;stressor;Study Subject;Symptoms;Tobacco;tobacco abstinence;Tobacco Dependence;Tobacco smoking behavior;Tobacco use;Tobacco Use Cessation;tobacco user;Visit;Withdrawal;Withdrawal Symptom;Woman

PROJECT_TITLE: Psychopharmacological effects of cannabidiol on responses to stress and nicotine withdrawal

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease;Kidney Disease;Prevention

ORG_CITY: KANSAS CITY

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: Project Narrative Vascular calcification (VC) occurring in chronic kidney disease is a significant cause of morbidity and mortality. Calciprotein particles (CPPs) and extracellular vesicles play a major role in driving VC. This study aims to investigate the use of a new peptide to block the CPP mediated VC in chronic renal disease and end stage renal disease (dialysis). Also, this work will test a new potential therapeutic, reveal new drug targets and provide a new understanding of the regulation of the role of calciprotein particles in vascular calcification.

PI_NAMEs: ROWE, PETER S (contact);STUBBS, JASON

PROGRAM_OFFICER_NAME: STABLEY, JOHN N

PROJECT_TERMS: Acceleration;Affect;American;Antibodies;Aorta;Aspartic Acid;Atherosclerosis;Automobile Driving;Binding;Biological Assay;Blood Vessels;Bone Matrix;calcification;Cessation of life;Chronic;Chronic Kidney Failure;Circulation;colloidal nanoparticle;Consumption;Data;Deposition;Development;Dialysis patients;Dialysis procedure;Diet;disease model;Disease Progression;End stage renal failure;Enzyme-Linked Immunosorbent Assay;Etiology;experimental study;extracellular vesicles;Family;global health;Glycoproteins;Goals;Growth;High Fat Diet;Human;improved;In Vitro;in vivo;Incubated;Infusion procedures;inhibitor;inorganic phosphate;Integrin Binding;Kidney Diseases;Ligand Binding;Link;Mass Spectrum Analysis;Measures;Mediating;MEPE gene;mineralization;Minerals;Morbidity - disease rate;mortality;mortality risk;Mus;Nephrectomy;new therapeutic target;Osteoblasts;osteogenic;particle;Pathway interactions;Patients;Peptides;Phenotype;Phosphorylation;Play;Population;prevent;Prevention;Process;Protein Dephosphorylation;Proteins;Quality of life;Rattus;Regulation;Renal dialysis;Renal function;Research;Risk;Rodent;Rodent Diseases;Rodent Model;Role;Sampling;Secondary to;Serine;Serum;sevelamer;Severities;Signal Pathway;skeletal;Smooth Muscle Myocytes;Testing;Therapeutic;therapeutically effective;Time;Tissues;Vascular calcification;Vascular Smooth Muscle;Vesicle;Work

PROJECT_TITLE: Preventing vascular calcification in kidney disease

STUDY_SECTION: AVI

STUDY_SECTION_NAME: Atherosclerosis and Vascular Inflammation Study Section[AVI]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering

ORG_CITY: GALVESTON

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

PHR: NARRATIVE Metabolic labeling with heavy water followed by LC-MS is used to study the turnover of individual proteins in vivo. Protein turnover is a fundamental biological process that is dysregulated in many diseases. This work will result in novel computational tools that increase proteome coverage and statistical power of protein turnover estimations and will help to reduce the dose, sampling frequency, and duration of labeling.

PI_NAMEs: SADYGOV, ROVSHAN G (contact)

PROGRAM_OFFICER_NAME: BARNES, CHARLES ASHLEY

PROJECT_TERMS: Affect;Amino Acids;Animal Model;base;Biogenesis;Bioinformatics;bioinformatics tool;Biological Process;Blood;Brain;Canis familiaris;Catabolism;Characteristics;Charge;Chromatography;Computational Technique;computerized data processing;computerized tools;Computing Methodologies;cost effective;Coupled;Data;Data Analyses;data integration;Dependence;Detection;Deuterium;Deuterium Oxide;Development;Disease;Dose;Equation;Equilibrium;experimental study;Fishes;Frequencies;Goals;Heart;improved;in vivo;Individual;Ions;isotope incorporation;Isotope Labeling;Isotopes;Kidney;kinetic model;Kinetics;Label;Link;Lipids;Liquid Chromatography;Liver;Mass Spectrum Analysis;Measurement;Metabolic;Methods;Modeling;Mus;Nature;Noise;Non-Essential Amino Acid;novel;novel strategies;Nucleic Acids;Pathway interactions;Peptides;Play;Protein Biosynthesis;protein degradation;Protein Dynamics;Proteins;Proteome;Rattus;Recycling;Resources;Role;Sampling;Scanning;Signal Transduction;Source;stable isotope;Stable Isotope Labeling;Statistical Data Interpretation;Statistical Models;Techniques;Time;tool;Tracer;virtual;Width;Work

PROJECT_TITLE: Protein turnover estimation from fragment ions and precursor enrichment in heavy water labeled LC-MS experiments

STUDY_SECTION: BDMA

STUDY_SECTION_NAME: Biodata Management and Analysis Study Section[BDMA]


NIH_SPENDING_CATS: Assistive Technology;Behavioral and Social Science;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Neurosciences;Physical Injury - Accidents and Adverse Effects;Physical Rehabilitation;Rehabilitation;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_DEPT: NEUROLOGY

PHR: PROJECT NARRATIVE There are >200,000 patients living with severe motor disability as a result of tetraplegia or severe tetrapereisis resulting from multiple neurological disorders. Brain-Computer Interfaces (BCIs) can reduce the extent of disability by allowing direct neural control of assistive devices. Our proposal aims to test whether a BCI using electrocorticography can allow such patients to control a complex robotic arm to perform a range of clinically relevant dexterous tasks.

PI_NAMEs: CHANG, EDWARD ;GANGULY, KARUNESH  (contact)

PROGRAM_OFFICER_NAME: NURMINSKAYA, MARIA

PROJECT_TERMS: Accounting;Activities of Daily Living;Algorithms;Amyotrophic Lateral Sclerosis;arm;arm function;assistive robot;Attention;brain based;brain computer interface;Brain Stem;Calibration;Clinical;clinically relevant;cognitive load;Complex;Crowding;Cues;Data;Devices;disability;Drops;Electrocorticogram;Environment;Exhibits;experience;Eye;Fatigue;flexibility;Freedom;Frequencies;gain of function;gaze;Goals;grasp;Hand;Hand functions;Home;Home environment;improved;Individual;Intuition;Joints;kinematics;Language;Learning;Limb structure;Mechanics;Methods;Modeling;Motor disability;Movement;multitask;Nervous System Disorder;neural;neural correlate;neuroprosthesis;neuroregulation;Outcome;Outcome Measure;Paralysed;Patients;Performance;Play;prevent;Process;Publishing;Quadriplegia;Quality of life;Research;restoration;Robot;robot control;robotic device;Robotics;Self-Help Devices;Seminal;Shapes;Signal Transduction;skills;Speech;Spinal cord injury;Stroke;Surveys;System;Target Populations;Technology;Testing;Thumb structure;Time;Training;Translations;Update;visual search;Work

PROJECT_TITLE: Long-term reliable neuroprosthetic control of a robotic arm and hand using electrocorticography.

STUDY_SECTION: BNVT

STUDY_SECTION_NAME: Bioengineering of Neuroscience, Vision and Low Vision Technologies Study Section[BNVT]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Infectious Diseases

ORG_CITY: COLLEGE STATION

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: TEXAS ENGINEERING EXPERIMENT STATION

PHR: PROJECT NARRATIVE The proposed research holds significant relevance to public health as it aims to determine the mechanisms by which bacteria adapt to biological and biomedical interfaces through tactile sensing. Novel biophysical assays will be pioneered to investigate how tactile sensing induces the formation of biofilms and other forms of communities. The research aligns with the NIH's mission to understand the fundamental biological processes that can lead to the prevention of infections and chronic disease.

PI_NAMEs: LELE, PUSHKAR PRAKASH (contact)

PROGRAM_OFFICER_NAME: FLICKER, PAULA F

PROJECT_TERMS: Active Biological Transport;Address;Adhesions;Affinity;Agar;Anti-Bacterial Agents;Antibiotic Resistance;appendage;Bacteria;bacterial community;Bacterial Infections;Bacterial Physiology;Biochemical;Biological;Biological Assay;Biological Process;biophysical techniques;Biophysics;Cell division;Cell membrane;Cell Physiology;Cell Wall;Cells;Chemotaxis;Chronic;Chronic Disease;chronic infection;Clinical;Communities;Complex;cost;Couples;Data;Development;dimer;Engineering;Environment;Escherichia coli;Event;experience;extracellular;Feedback;Filament;Flagella;Fluorescence;Goals;Health Care Costs;Healthcare;Homeostasis;Individual;Infection prevention;innovation;insight;Investigation;Knowledge;laser tweezer;Life Style;Link;Measurement;Measures;mechanical force;mechanical properties;mechanical signal;Mechanical Stimulation;mechanical stimulus;Mechanics;mechanotransduction;Mediating;Membrane;Microbial Biofilms;Mission;Modeling;Molecular Biology;Motility;Motor;novel;Nutrient;Obstruction;optic tweezer;Output;Pathogenesis;Phenotype;Phosphotransferases;Physiological;Play;prevent;Property;Proteins;Proton-Motive Force;Public Health;recruit;Regulation;Research;Research Personnel;Resistance;Resistance to infection;response;Role;Rotation;sensor;Signal Transduction;simulation;single molecule;Structure;Surface;Tactile;Testing;tool;Torque;transmission process;United States National Institutes of Health;Validation;Viscosity;Work

PROJECT_TITLE: Mechanical Regulation of Chemotaxis Signaling by Bacterial Mechanosensors

STUDY_SECTION: PCMB

STUDY_SECTION_NAME: Prokaryotic Cell and Molecular Biology Study Section[PCMB]


NIH_SPENDING_CATS: Biotechnology;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Liver Disease;Regenerative Medicine

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Liver transplantation is the only curative option for patients with liver cirrhosis and there are no regenerative therapies available, although they are urgently needed. We identified a novel growth factor that induces proliferation of hepatocytes suggesting it improves liver regeneration. As this there are known and FDA-approved compounds to enhance or inhibit this pathway, we propose to assess if these compounds can be used to improve liver regeneration, which could eventually improve patient outcomes.

PI_NAMEs: LEE, YOUNGMIN ANNA (contact)

PROGRAM_OFFICER_NAME: BURGESS-BEUSSE, BONNIE L

PROJECT_TERMS: Adoptive Transfer;Agonist;antagonist;Atrophic;Autophagocytosis;Body Weight;Catecholamines;Cell Culture Techniques;Cell Death;cell growth;Cell Line;Cells;Chemosensitization;Complication;CRISPR/Cas technology;curative treatments;Data;Death Rate;detection of nutrient;Donor person;EGF gene;end stage liver disease;engineered T cells;Ensure;Equilibrium;Failure;Family;FDA approved;Fibrosis;Genes;Genetic;Goals;Growth;Growth Factor;Hepatectomy;Hepatic;Hepatic Fibrogenesis;Hepatic Mass;Hepatic Stellate Cell;Hepatocyte;HepG2;Homeostasis;Human;improved;inhibition of autophagy;inhibitor;Injury;innovation;insight;Intervention;Knockout Mice;Label;Lipids;Liver;liver cell proliferation;Liver Cirrhosis;Liver Failure;Liver Regeneration;liver transplantation;Living Donors;LoxP-flanked allele;member;Messenger RNA;Metabolic;Mitogens;Modeling;mouse model;Mus;Natural regeneration;Nerve Growth Factors;neuronal survival;Neurotrophic Tyrosine Kinase Receptor Type 3;Neurotrophin 3;novel;NTRK1 gene;NTRK2 gene;NTRK3 gene;nutrient deprivation;Organ;Organoids;overexpression;paracrine;Partial Hepatectomy;Pathway interactions;Patient-Focused Outcomes;Patients;Phosphorylation;pre-clinical;Printing;Process;Proliferating;Proteins;receptor;Receptor Signaling;regeneration potential;regenerative;Regenerative capacity;Regenerative pathway;regenerative therapy;Repression;Research;Rodent;Rodent Model;Role;Science;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Syndrome;synergism;Testing;Therapeutic;Time;tool;transcriptome;transcriptomics;tropomyosin kinase;tumorigenesis;Work

PROJECT_TITLE: Hepatic stellate cells in liver homeostasis and regeneration

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


NIH_SPENDING_CATS: Cancer;Chronic Pain;Natural Products;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy

PHR: Narrative/Public Health Relevance Paclitaxel-induced peripheral sensory neuropathy (PIPN) accompanied by neuropathic pain is particularly severe and is often a limiting factor in treatment for cancer patients receiving paclitaxel infusion. However, mechanisms underlying the pathogenesis of PIPN are uncertain, which hinders the development of effective therapies for this comorbidity. The proposed studies attempt to identify potential molecular/cellular mechanisms underlying PIPN.

PI_NAMEs: YANG, QING  (contact)

PROGRAM_OFFICER_NAME: ALTSHULER, RACHEL DINA

PROJECT_TERMS: Acute;Acute Pain;Adverse effects;Affect;afferent nerve;Afferent Neurons;aggressive therapy;Animal Model;Animals;anti-cancer;Attenuated;Autophagosome;Axon;behavior test;Buffers;cancer cell;Cancer Patient;cancer therapy;carcinogenesis;channel blockers;chemotherapy;Chronic;chronic neuropathic pain;Clinical Trials;clinically relevant;comorbidity;Coupled;Creatine;Data;designer receptors exclusively activated by designer drugs;Development;Disseminated Malignant Neoplasm;effective therapy;Effectiveness;effectiveness evaluation;efficacy evaluation;experience;experimental study;Fiber;Food and Drug Administration Drug Approval;Functional disorder;Genetic;Goals;high risk;Homeostasis;Human;Image;Immunohistochemistry;Impairment;In Vitro;in vivo;Induced Neurons;Infusion procedures;Injections;interdisciplinary approach;Lead;Limb structure;Link;live cell imaging;Maintenance;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of ovary;Measures;Medicine;Mitochondria;mitochondrial dysfunction;Molecular;Monitor;Movement;Mus;Neoplasm Metastasis;neuronal cell body;neuronal excitability;Neurons;neurotoxicity;Nociceptors;novel;Organelles;Outcome;Paclitaxel;Pain;painful neuropathy;Pathogenesis;Pathologic;Patients;Peripheral;Peripheral Nervous System Diseases;Pharmaceutical Preparations;Play;Potassium Channel;pre-clinical;preclinical study;prevent;Process;protein distribution;Proteins;public health relevance;Publishing;Quality of life;quality of life for cancer survivors;real-time images;response;Rodent;Role;Sensory;sensory neuropathy;spatiotemporal;Spinal Ganglia;Structure;Supplementation;Survivors;Suspensions;Testing;tool;Transmission Electron Microscopy;Transportation;tumor;Tumor Burden

PROJECT_TITLE: The role of acute excitation of sensory neurons in the development of paclitaxel-induced peripheral neuropathy

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biotechnology;Brain Disorders;Cerebrovascular;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: LAWRENCE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF KANSAS LAWRENCE

PHR: PROJECT NARRATIVE This project is aimed at developing a novel delivery method for delivering drugs to treat Central Nervous System (CNS) disorders. Using our novel blood-brain barrier modulators (BBBMs), we now can selectively deliver protein therapeutic and diagnostic agents into the brains of healthy and disease animal models without affecting other organs. Our novel delivery method can be transformed from preclinical animal studies to clinical studies in patients.

PI_NAMEs: KUCZERA, KRZYSZTOF ;SIAHAAN, TERUNA J. (contact);ZHAO, LIQIN

PROGRAM_OFFICER_NAME: RUNKO, ALEXANDER PETER

PROJECT_TERMS: 3-Dimensional;Affect;age related neurodegeneration;Alzheimer's Disease;Animal Disease Models;Animal Model;Animals;Antineoplastic Agents;apolipoprotein E-4;APP-PS1;Binding;Biological;Blood;Blood - brain barrier anatomy;Blood Circulation;blood-brain barrier crossing;Brain;Brain Diseases;Brain Injuries;Brain Neoplasms;brain pathway;Brain-Derived Neurotrophic Factor;cadherin 5;Cadherins;Cell-Cell Adhesion;Cells;Central Nervous System;Central Nervous System Diseases;cerebral microvasculature;Chemical Structure;Clinical Research;cognitive function;Complex;Computer Models;Cytoplasm;design;Development;Diagnosis;Diagnostic;Diffusion;Disease;Drug Delivery Systems;Drug Kinetics;drug metabolism;Drug Targeting;Drug Transport;Effectiveness;Endothelial Cells;Enzymes;familial Alzheimer disease;Goals;Human;improved;In Vitro;in vitro Model;in vivo;Intercellular Junctions;Knock-in Mouse;Lead;Learning;Left;Length;Mediating;Medulloblastoma;Memory;Mental disorders;Methods;Molecular;Molecular Probes;Monitor;Monoclonal Antibodies;mouse model;Multiple Sclerosis;Mus;mutant;nanoparticle;Nerve Degeneration;Nervous System Disorder;neuropathology;neurotrophic factor;next generation;novel;novel therapeutics;occludin;Organ;Pathway interactions;Patients;peptide drug;Peptides;Peripheral;Pharmaceutical Preparations;Porosity;pre-clinical;prevent;programs;Property;Proteins;Recurrent disease;Signal Transduction;Small Interfering RNA;Synapses;System;Therapeutic;Therapeutic Agents;therapeutic protein;Tight Junctions;tool;Toxic effect;United States National Institutes of Health;virtual experiments;virtual screening;Work

PROJECT_TITLE: A Novel Method to Enhance Drug Delivery to the Brain

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BN-V (91)]


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Nutrition;Orphan Drug;Pancreatic Cancer;Rare Diseases

ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE The tumor microenvironment of pancreatic adenocarcinomas endows these tumors with profound resistance to chemotherapies, which severely hinders clinical management of this disease. We have found that nutrient availability in pancreatic tumors is a key microenvironmental factor that leads to this therapy resistance. In this proposal, we will determine the molecular mechanisms by which tumor nutrition imparts therapy resistance upon pancreatic cancer cells, and if manipulating tumor nutrition and its impact on pancreatic cancer cells can sensitize pancreatic tumors to chemotherapies, which may lead to new therapeutic approaches in this disease.

PI_NAMEs: MUIR, ALEXANDER  (contact)

PROGRAM_OFFICER_NAME: MERCER, NATALIA

PROJECT_TERMS: Address;Adenocarcinoma Cell;Affect;Amino Acids;antagonist;Apoptotic;Atlases;bcl-xlong protein;BCL2L1 gene;Biological Models;Biology;Cell Culture Techniques;Cell Death;Cell Death Signaling Process;Cells;Chemoprotection;Chemoprotective Agent;Chemoresistance;chemotherapy;Chemotherapy-Oncologic Procedure;Circulation;Clinical;Clinical Management;clinically relevant;Cues;Desmoplastic;Disease;Disease Management;drug action;Drug Delivery Systems;Endowment;Exhibits;Exposure to;Glycine;Goals;Human;Impairment;imprint;improved;inhibitor;insight;Intercellular Fluid;Malignant neoplasm of pancreas;Measures;Mediating;Mediator;Metabolic;Metabolism;Modeling;Molecular;Molecular Target;mouse model;Mus;novel;novel therapeutic intervention;novel therapeutics;Nutrient;Nutrient availability;nutrient metabolism;nutrition;Outcome;Pancreatic Adenocarcinoma;pancreatic cancer cells;pancreatic neoplasm;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;pharmacologic;Phenotype;Physiological;Physiology;prevent;Prognosis;Resistance;response;Stress;synergism;Techniques;Testing;Therapeutic;Therapeutic Intervention;therapy resistant;Tissues;treatment response;tumor;tumor microenvironment;tumor progression;Vitamins;Work

PROJECT_TITLE: Targeting nutrient microenvironment imprinted therapy resistance in pancreatic cancer


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Behavioral and Social Science;Brain Disorders;Clinical Research;Machine Learning and Artificial Intelligence;Mental Health;Neurosciences;Sleep Research

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: Project Narrative Delirium is an acute and dynamic disturbance of attention and awareness that afflicts >20% of hospitalized older adults and costs up to $152 billion each year, yet has no FDA approved therapies. This project will use new monitoring tools to determine the temporal characteristics, sleep and circadian causes, and long-term cognitive impact of the acute course of delirium in older adults. Such tools will establish a firm physiologic foundation, objective biomarkers, and critical targets to identify, understand, and ameliorate delirium’s significant and distressing effects, including its associations with long-term cognitive impairment and Alzheimer’s Disease.

PI_NAMEs: KIMCHI, EYAL YAACOV (contact)

PROGRAM_OFFICER_NAME: ROBERTS, LUCI

PROJECT_TERMS: Acceleration;actigraphy;Acute;Admission activity;Adult;Affect;Age;algorithm development;Alzheimer's Disease;artificial intelligence algorithm;Attention;Awareness;Biological Markers;brain health;Characteristics;circadian;circadian biology;Circadian Dysregulation;Circadian Rhythms;Clinical;Clinical Trials;Cognition;Cognitive;cognitive testing;community acquired pneumonia;cost;Crystallization;deep neural network;Delirium;Dementia;Distress;Electroencephalography;Endogenous Factors;Environmental Risk Factor;Event;FDA approved;follow-up;Foundations;Frequencies;Goals;Heart Rate;Home;Hospitalization;Hospitals;Hour;human old age (65+);Impaired cognition;improved;Incidence;individual patient;informant;innovation;Intelligence;Knowledge;Light;Measures;Mediating;Methods;Modeling;Monitor;multimodality;Neural Network Simulation;Noise;novel;older adult;Outcome;Patients;Pattern;Pharmaceutical Preparations;Physiological;Pilot Projects;Pneumonia;Positioning Attribute;Questionnaires;recruit;REM Sleep;Research;Respiration;Risk;Risk Factors;Severities;Severity of illness;Sleep;Sleep disturbances;Sleep Fragmentations;Staging;Stimulus;Symptoms;Testing;Therapeutic;therapeutic target;Time;tool;Touch sensation;transcriptomics;Variant;wearable device;wearable sensor technology;wireless;Work

PROJECT_TITLE: Delirium Dynamics: Understanding Causes and Effects

STUDY_SECTION: ASG

STUDY_SECTION_NAME: Aging Systems and Geriatrics Study Section[ASG]


NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Clinical Research;Digestive Diseases;Pancreatic Cancer;Precision Medicine;Rare Diseases

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

PHR: Project Narrative The proposed project will develop a new approach to monitor and predict treatment response in patients with pancreatic ductal adenocarcinoma using hyperpolarized 13C pyruvate MR molecular imaging. The data from this first study will inform future investigations incorporating metabolic imaging biomarkers for defining clinically relevant thresholds, enable timely therapy switch in non-responders, and guide high-stake decisions about the benefit of a highly morbid surgery, with the overarching goal of better guiding treatment decisions to improve survival of patients with this deadly disease.

PI_NAMEs: GORDON, JEREMY WILLIAM (contact);WANG, ZHEN JANE

PROGRAM_OFFICER_NAME: TANDON, PUSHPA

PROJECT_TERMS: Abdomen;Address;Alanine;alternative treatment;Anatomy;Assessment tool;CA-19-9 Antigen;Cancer Etiology;Cessation of life;Clinical;clinical care;clinical decision-making;Clinical Research;clinically relevant;cohort;Compensation;cost effective;Data;design;Development;Disease;DNA Sequence Alteration;Early treatment;Evaluation;Excision;fluorodeoxyglucose positron emission tomography;Future;Genes;glucose uptake;Glycolysis;Goals;Image;imaging approach;imaging biomarker;imaging modality;improved;ineffective therapies;Investigation;KRAS2 gene;lactate dehydrogenase A;Life;Magnetic Resonance Imaging;Malignant neoplasm of pancreas;Malignant Neoplasms;Measures;Metabolic;metabolic imaging;Metabolism;Methods;Minority;Modeling;molecular imaging;Monitor;Motion;Neoadjuvant Therapy;novel;novel strategies;Operative Surgical Procedures;outcome prediction;overexpression;Pancreas;Pancreatic Ductal Adenocarcinoma;Pathologic;Pathway interactions;Patient Selection;Patients;Phosphorylation;Play;predicting response;Prediction of Response to Therapy;Pyruvate;Pyruvate Metabolism Pathway;Research;Resectable;Resected;Resistance;Resolution;response;Role;Running;Scanning;Serum;simulation;stable isotope;Systemic disease;Systemic Therapy;Techniques;Time;tool;Translating;treatment response;tumor;Tumor Markers;United States National Institutes of Health;Variant;X-Ray Computed Tomography

PROJECT_TITLE: Translating Hyperpolarized 13C MRI as a Novel Tool to Predict Treatment Response in Pancreatic Cancer

STUDY_SECTION: IGIS

STUDY_SECTION_NAME: Imaging Guided Interventions and Surgery Study Section[IGIS]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Bioengineering;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Kidney Disease;Liver Disease;Nanotechnology;Substance Misuse

ORG_CITY: OMAHA

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: Oxidative stress is an established risk factor for alcohol-related organ injury. In this project, we will examine the influence of superoxide dismutase 1 (SOD1), an antioxidant enzyme, on the activities of two proteins (AMP-activated protein kinase and catalase), which are known to alter liver and fat tissue injury. Further, we will evaluate the effectiveness of a novel SOD1 nanoparticle, in reducing alcohol-induced organ injury.

PI_NAMEs: CASEY, CAROL A.;VISWANATHAN, SARASWATHI  (contact)

PROGRAM_OFFICER_NAME: MURRAY, GARY

PROJECT_TERMS: 5'-AMP-activated protein kinase;Adenosine Monophosphate;Adipocytes;Adipose tissue;alcohol exposure;Alcohol-Induced Disorders;Alcoholic Liver Diseases;Alcohols;antioxidant enzyme;Antioxidants;Attenuated;attenuation;Autophagocytosis;Biogenesis;C57BL/6 Mouse;catalase;Chronic;Data;Development;Diet;Effectiveness;effectiveness evaluation;efficacy evaluation;Ethanol;Ethanol Metabolism;exosome;Exposure to;Fatty acid glycerol esters;feeding;Fibrosis;Functional disorder;Generations;Genetic;Goals;Hepatic;Hepatocyte;hepatoprotective;Human;Hydrogen Peroxide;Impairment;improved;in vivo;Inflammation;Inflammatory;insight;Knockout Mice;Link;Lipids;Lipolysis;Liver;Liver diseases;liver injury;liver transplantation;mannose receptor;Mediating;Molecular;Morbidity - disease rate;multiorgan damage;Mus;nanoparticle;novel;novel therapeutics;Organ;organ injury;Oxidation-Reduction;Oxidative Stress;Pathogenesis;pharmacologic;Phosphorylation;Plasma;primary endpoint;protective effect;Protein Kinase;Proteins;Regulation;Risk Factors;Role;Serum;Signal Transduction;Slice;superoxide dismutase 1;Testing;Therapeutic;tissue injury;Tissues

PROJECT_TITLE: Redox Signaling and AMPK Crosstalk on Alcohol-Induced Multi-Organ Damage: Liver and Adipose TIssue


ORG_DEPT: GENETICS

PHR: One of the major challenges of gene therapy is the lack of technologies to deliver healthy-gene copies to target tissues/cells. A recently developed tool called SEND (for selective endogenous encapsidation for cellular delivery) offers solution to the problem but this newly invented technology requires investigation further refinement and validating the technology in animal models. In this project we will develop prototype systems of the SEND technology for use as gene therapy tool.

PI_NAMEs: GURUMURTHY, CHANNABASAVAIAH  (contact)

PROGRAM_OFFICER_NAME: KODURI, SAILAJA

PROJECT_TERMS: Adult;Aging;Animal Model;Antisense Oligonucleotides;Area;Award;Biogenesis;Capsid;Capsid Proteins;Cell membrane;Cell Physiology;Cells;clinical application;Clinical Trials;Communities;Companions;Data;design;Development;Disease;Encapsulated;Engineering;Evolution;Fetal Diseases;Formulation;Future;gene delivery system;gene editing technology;gene therapy;Genes;Genetic;Genetic Diseases;Genetic Engineering;Genetic Materials;Genetically Engineered Mouse;Goals;human disease;immunogenicity;In Vitro;in vivo;Individual;invention;Investigation;Laboratories;Learning;life span;lipid nanoparticle;Liver;Membrane;Messenger RNA;Methods;Modeling;mouse model;mRNA delivery;Mus;nanoformulation;nanoparticle;nucleic acid delivery;Nucleic Acids;particle;Pathology;Physiology;Plasmids;Process;Property;Proteins;prototype;Reporter;Reporting;Research;Retroviridae;RNA Interference;Role;Science;Specific qualifier value;success;System;Technology;technology development;technology platform;technology validation;Testing;Therapeutic;therapeutic gene;Time;Tissues;tool;Toxic effect;Untranslated Regions;Uterus;Viral;Viral Vector;Whole Organism;Work

PROJECT_TITLE: Prototype Mouse Models for SEND-Based mRNA Delivery and Technology Development

STUDY_SECTION: CMT

STUDY_SECTION_NAME: Cellular and Molecular Technologies Study Section[CMT]


NIH_SPENDING_CATS: Autism;Brain Disorders;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: 1$55$7,9( Published estimates indicate that 1 in 44 children are diagnosed with Autism Spectrum Disorder (ASD) (https://www.cdc.gov/), and while many genetic causes of ASD and related neurodevelopmental disorders have now been identified, our understanding of how disruption of genes drives nervous system dysfunction in these disorders remains limited. This project will study how mutation of genes associated with ASD and related disorders impacts a specialized DNA methylation pathway in the brain, leading to alterations in neuronal gene expression and disrupted circuit function. This work will define fundamental biology that is essential to the normal function of the nervous system and explore how it may be disrupted in disease, laying the groundwork for future therapeutic development.

PI_NAMEs: GABEL, HARRISON W (contact)

PROGRAM_OFFICER_NAME: LEINWAND, SARAH GOLDBERG

PROJECT_TERMS: Address;analysis pipeline;ASH1L gene;autism spectrum disorder;Binding;Biology;Brain;cell type;Cells;Child;CpG dinucleotide;Cytosine;Deposition;Diagnosis;Dinucleoside Phosphates;Disease;DNA;DNA Methylation;DNMT3a;DNMT3a mutation;Enhancers;Enzymes;Epigenetic Process;epigenetic regulation;epigenomic profiling;epigenomics;Etiology;Functional disorder;Future;Gene Expression;Gene Mutation;gene repression;Genes;Genetic;Genetic Transcription;Genome;Genomics;Goals;Grant;Histone H3;Histones;in vivo;innovation;insight;Lesion;Lysine;Mammalian Cell;Methyl-CpG-Binding Protein 2;Methylation;methylation pattern;Methyltransferase;Modification;Molecular;Mutant Strains Mice;Mutate;Mutation;Nervous System;nervous system development;Nervous System Physiology;Neurodevelopmental Disorder;Neuroglia;Neuronal Dysfunction;neuronal patterning;Neurons;Output;Pathway interactions;Pattern;Phenotype;Play;Predisposition;programs;Property;Proteins;Publishing;Regulation;Resolution;Rett Syndrome;Role;Site;Structure;System;Technology;Testing;therapeutic development;Transcriptional Regulation;transcriptome;transcriptomics;Work

PROJECT_TITLE: MECHANISMS OF EPIGENETIC REGULATION IN NERVOUS SYSTEM DEVELOPMENT

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Mental Health;Mental Illness;Neurosciences;Post-Traumatic Stress Disorder (PTSD);Rehabilitation;Serious Mental Illness

ORG_CITY: AUSTIN

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

ORG_STATE: TX

PHR: Project Narrative Posttraumatic stress disorder (PTSD) is a prevalent and impairing mental health condition, and symptoms of diminished positive affect (e.g., difficulty experiencing positive emotions, diminished interest) are consistently associated with poorer quality of life and worse clinical outcomes. Cognitive processing therapy (CPT) is an evidence-based trauma-focused psychotherapy with abundant evidence of clinical efficacy, but the neurobiological mechanisms by which trauma-focused psychotherapies, such as CPT, promote improvements in symptoms of diminished positive affect are not at all understood. The long-term public health goal of this project is to identify how CPT promotes changes in the function and information processing of neural circuitry involved in positive affect using reward processing paradigms and brain imaging, which will serve to inform our understanding of existing efficacious trauma-focused treatments and provide new opportunities for improving PTSD treatment outcomes through targeting the neural mechanisms underlying this poorly understood symptom cluster.

PI_NAMEs: FONZO, GREGORY  (contact)

PROGRAM_OFFICER_NAME: BORJA, SUSAN EILEEN

PROJECT_TERMS: Affect;Amygdaloid structure;Anhedonia;Area;arm;Attenuated;base;Behavior;Behavioral;behavioral study;Biological;blood oxygen level dependent;Brain;brain dysfunction;Brain imaging;Chronic;Chronic Post Traumatic Stress Disorder;Clinical;clinical efficacy;clinically relevant;Code;Cognitive;comorbidity;Computer Models;Corpus striatum structure;Data;Decision Making;Diagnostic;Distress;Emotional;Ensure;Environment;Event;evidence base;expectation;experience;experimental study;Frequencies;Functional impairment;Functional Magnetic Resonance Imaging;Future;Goals;health goals;Impairment;improved;Individual;information processing;interest;Intervention;Knowledge;Learning;lens;Major Depressive Disorder;Measures;Mediating;Mental Health;Mentored Patient-Oriented Research Career Development Award;Modeling;neural;neural circuit;neural information processing;neural recruitment;neurobiological mechanism;Neurobiology;neuroimaging;neuromechanism;novel;Numbness;Outcome;Participant;positive emotional state;post-trauma;Post-Traumatic Stress Disorders;Prefrontal Cortex;Process;Psychological reinforcement;Psychopathology;Psychotherapy;Public Health;Quality of life;Randomized;randomized, clinical trials;recruit;response;reward circuitry;reward processing;Rewards;Safety;Shock;Signal Transduction;suicidal;symptom cluster;Symptoms;Techniques;Therapeutic;Therapeutic Effect;Trauma;traumatic event;Treatment outcome;Ventral Striatum;Work

PROJECT_TITLE: The effects of trauma-focused psychotherapy on reward circuitry function and information encoding

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Depression;Mental Health;Mental Illness;Neurosciences;Pediatric;Tourette Syndrome

PHR: PROJECT NARRATIVE Over 20% of all children have tics at some time in their life, making tic disorders like Tourette syndrome a subject of substantial public health interest. Our colleagues enrolled over 300 children, beginning at ages 3-5, without selecting for presence or absence of tics, and have followed them up for 15 years at study visits that included video recordings of the child in addition to diagnostic interviews, a wealth of psychological data, and for later visits structural and functional MRI of the brain. This unique data set allows us to identify clinical features prior to the onset of tics in children who show tics on video at later visits, and to identify clinical or brain imaging predictors of tic outcome at visits when children first manifest tics.

PI_NAMEs: BLACK, KEVIN J (contact)

PROGRAM_OFFICER_NAME: THOMAS, LAURA ANDERSON

PROJECT_TERMS: 21 year old;Address;Adolescence;Age;Anxiety;Anxiety Disorders;Attention deficit hyperactivity disorder;behavior measurement;Behavioral;Biological Markers;biomedical referral center;Brain;Brain imaging;brain magnetic resonance imaging;Child;Childhood;Chronic;Chronic Disease;Clinical;Clinical assessments;clinical care;clinical imaging;Clip;Data;Data Set;depressive symptoms;Detection;Development;Diagnosis;Diagnostic;Disease;Disease remission;Dissociation;Enrollment;epidemiology study;Etiology;examination questions;Exclusion;experience;follow-up;Follow-Up Studies;Frustration;Functional disorder;Functional Magnetic Resonance Imaging;Funding;Gilles de la Tourette syndrome;Immune;Impairment;improved;Individual;insight;interest;Interview;Life;Longitudinal Studies;Longitudinal, observational study;Magnetic Resonance Imaging;Mental Depression;Motor;National Institute of Mental Health;Neuropsychology;novel;Nursery Schools;Outcome;outcome prediction;Participant;Patients;Physiology;Population;Prognosis;prospective;Prospective Studies;psychiatric symptom;psychologic;Psychopathology;Public Health;Quality of life;Recording of previous events;Reporting;Research;Research Personnel;Rest;Sampling;Secondary Prevention;Severities;side effect;Surveys;symptomatic improvement;Testing;Tic disorder;tic related;Time;trait;Video Recording;Visit;Work;young adult

PROJECT_TITLE: Preschool MRI predictors of tic outcomes from a 15-year longitudinal study

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: Chicago

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: NARRATIVE Understanding how contextual factors, including structural racism and discrimination (SRD), influence disparities in access to therapeutic services for Black and Hispanic children with developmental delays and disabilities are critical to inform educational and healthcare intervention and policy. The proposed research is significant for its potential to advance scientific knowledge about the role of SRD in creating disparities in access to care; how gaps and delays in therapeutic services impact child, family, parent and community health outcomes; and the role of multilevel protective factors in mitigating these effects.

PI_NAMEs: SHAH, RESHMA  (contact)

PROGRAM_OFFICER_NAME: PADGETT, LYNNE SLAUGHTER

PROJECT_TERMS: access disparities;Address;Area;Automobile Driving;Behavioral;Black race;Brain;Characteristics;Chicago;Child;Child Development;Child Rearing;Clinic;Clinical;Communities;Community Health;Competence;contextual factors;critical period;Data;Development;Developmental Delay Disorders;Developmental Disabilities;Diagnosis;disability;Discrimination;Disparity;early childhood;Education;Emotional;Enrollment;ethnic disparity;ethnic health disparity;Ethnic Origin;Etiology;evidence base;Family;Fostering;Funding;Future;Goals;Health;health care disparity;health care service;health equity;health inequalities;Health Insurance;Health Services Accessibility;Healthcare;Hispanic;improved;Income;Individual;Inequity;Insurance;Intervention;Knowledge;Learning;Literature;long-standing disparities;Longitudinal Studies;Measures;Medicaid;Medical;Mental Health;Methodology;Methods;Morbidity - disease rate;multidisciplinary;Neighborhoods;Nursery Schools;Outcome;Parents;Pediatrics;Policies;Preschool Child;Privatization;prospective;protective factors;Psychology;Public Health;public health intervention;Quality of life;Race;racial disparity;racial health disparity;racism;Research;resilience;Risk;Role;School-Age Population;Schools;Scientific Advances and Accomplishments;Scientist;Services;skills;social;Special Education;Speech Therapy;Stress;Structural Racism;System;Testing;Therapeutic;Time;United States;United States National Institutes of Health

PROJECT_TITLE: Examining Contextual and Protective Factors on Racial/Ethnic Health Disparities Among Preschool Children with Developmental Delays

STUDY_SECTION: HHD

STUDY_SECTION_NAME: Healthcare and Health Disparities Study Section[HHD]