NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Neurosciences;Opioid Misuse and Addiction;Opioids;Pain Research;Prevention;Sleep Research;Substance Misuse

ORG_CITY: Canton

ORG_NAME: HARVARD PILGRIM HEALTH CARE, INC.

PHR: There is a limiting understanding of the predictive value of metrics of sleep health and circadian rhythms – core to mental and physical health and well-being – for medications for opioid-use disorder (MOUD) outcomes. The proposed project will identify sleep and circadian phenotypes that are predictive of MOUD outcomes and can point to potential intervention targets. The proposed research is relevant to the NIH HEAL initiative's mission that pertains to conducting research to improve the treatment for opioid misuse and addiction.

PI_NAMEs: PURCELL, SHAUN M;REDLINE, SUSAN S.;WANG, RUI  (contact)

PROGRAM_OFFICER_NAME: NAIR, SUNILA GOPI

PROJECT_TERMS: addiction;Adherence;Adopted;Adverse event;Affect;Alcohol consumption;Algorithms;Architecture;Area;Biological Markers;Biometry;Caring;Case Report Form;Certification;Cessation of life;circadian;Circadian Rhythms;Clinical;Clinical Research;Collaborations;Collection;Common Data Element;Communication;Communities;craving;Data;Data Analyses;Data Collection;Data Coordinating Center;data ecosystem;Data Files;data integration;data management;Data Management Resources;data quality;Data Science;Data Set;data sharing;data standards;design;Detection;Development;distributed data;Documentation;Drops;Electroencephalography;Electronics;Eligibility Determination;emotion dysregulation;Enrollment;Ensure;Epidemiologist;Epidemiology;experience;Family;fitbit;Future;Generations;Goals;Healthcare;Helping to End Addiction Long-term;Hospitals;illicit drug use;improved;Individual;innovation;Institutional Review Boards;Intervention;Laboratories;Lead;Leadership;limb movement;machine learning algorithm;Manuals;Manuscripts;Measures;medication for opioid use disorder;Medicine;member;Mental disorders;Mental Health;Metadata;Mission;Monitor;Multicenter Studies;multidisciplinary;neurophysiology;non rapid eye movement;Online Systems;Opiate Addiction;Opioid;opioid misuse;opioid use disorder;Outcome;Pain;Pain intensity;Pain interference;participant enrollment;participant retention;Pathway interactions;Patient Recruitments;Pattern;Periodicals;Personal Satisfaction;Persons;Phase;Phenotype;Physical activity;physical conditioning;Physical Function;Polysomnography;Prediction of Response to Therapy;predictive modeling;Predictive Value;Preparation;primary endpoint;Procedures;programs;Protocols documentation;Public Health;quality assurance;Quality Control;Questionnaires;Reading;Recovery;recruit;Report (document);Reporting;Research;Research Training;Resolution;Resources;retention rate;Risk Factors;Safety;Scientist;secondary outcome;Secure;Services;Signal Transduction;Site;skills;Sleep;Sleep Apnea Syndromes;Sleep Architecture;Sleep disturbances;sleep health;sleep quality;Specialist;standard measure;Standardization;statistical and machine learning;Statistical Data Interpretation;Stress;Summary Reports;Support System;System;systematic review;Testing;Time;Training;treatment adherence;Treatment Effectiveness;Treatment outcome;treatment response;United States National Institutes of Health;Validation;wearable data;web site;web-accessible;Withdrawal Symptom;Woman;Work;Writing

PROJECT_TITLE: Value of Sleep Metrics in Predicting Opioid-Use Disorder Treatment Outcomes: Leadership and Data Coordinating Center


ADMINISTERING_IC: CA

ARRA_FUNDED: N

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Cervical Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Networking and Information Technology R&D (NITRD);Prevention;Primary Health Care;Social Determinants of Health;Telehealth;Women's Health Research

ORG_CITY: SAN DIEGO

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: PENSIEVISION, INC.

ORG_STATE: CA

PHR: Project Narrative Cervical cancer is one of the most preventable and treatable forms of cancer, yet nearly 90% of cases in low- to middle-income countries result in death. To address this crisis, we recently developed a portable, low-cost, simple-to-use, telemedicine- and patient-friendly innovative imaging system that can help advance toward the screen-and-treat strategy for cervical cancer prevention advocated by the World Health Organization. In this phase II study, we will establish the feasibility of our screening protocols through a multisite international study and advance the overall technology.

PI_NAMEs: CARSON, JOSEPH  (contact)

PROGRAM_OFFICER_NAME: ZHAO, MING

PROJECT_TERMS: 3-Dimensional;Abnormal Epithelial Cell;Acute;Address;Advocate;Africa;Africa South of the Sahara;African;Area;Award;Biological Assay;Biopsy;cancer care;Cancer Center;cervical cancer prevention;Cervical Cancer Screening;Cervix Neoplasms;Cervix Uteri;Cessation of life;Clinical;Clinical Research;Clinical Trials;Color;Colposcopy;Computer software;Confidence Intervals;cost;Country;Data;Data Collection;Data Set;Death Rate;Developed Countries;Developing Countries;Devices;Diagnosis;Disease;Dysplasia;Effectiveness;Eligibility Determination;Epidemiology;Face;Factor Analysis;falls;follow-up;Friends;Future;Head;Health Care Costs;high resolution imaging;Human;Human Papillomavirus;Image;Imaging Device;imaging system;Imaging Techniques;Imaging technology;improved;Incidence;Income;Infrastructure;innovation;interest;International;Intervention;Kenya;Laboratories;longitudinal analysis;low and middle-income countries;Malawi;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Maps;marginalization;Measurable;Measurement;Measures;Medical;medical schools;new technology;novel;Oncology;Optics;Pap smear;Patient imaging;Patient-Focused Outcomes;Patients;Persons;Phase;phase 2 study;portability;Positioning Attribute;Poverty Areas;Predisposition;Procedures;programs;Property;Recommendation;reconstruction;Reproducibility;Reproductive Health;Research;research clinical testing;Resolution;Resource-limited setting;response;screening;screening program;Shapes;Site;Small Business Innovation Research Grant;socioeconomic disadvantage;socioeconomics;statistics;Sterility;Support Groups;Surveys;Technology;technology development;Telemedicine;Testing;Three-Dimensional Imaging;tool;treatment program;Uninsured;United States National Aeronautics and Space Administration;United States National Institutes of Health;usability;Virginia;virtual;Visit;Visual;Visualization;Woman;World Health Organization

PROJECT_TITLE: A Novel, Low-Cost, Handheld, 3D Imaging System for Improved Screening of Cervical Neoplasia in Resource Limited Settings

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ISB-Z(10)B]


FUNDING_MECHANISM: RESEARCH CENTERS

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prostate Cancer;Racial and Ethnic Minority Health Research;Urologic Diseases

ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PI_NAMEs: WEBB, FERN JUREIDINI (contact)

PROJECT_TERMS: Academy;Adult;Advisory Committees;Advocacy;Advocate;African American;anti-cancer research;behavior change;Benchmarking;Black American;Black church;Black Populations;Black race;California;cancer health disparity;cancer risk;Cancer Survivor;Caring;catalyst;Church;Clinical Research;Clinical Trials;Collaborations;Communication;Communities;community advisory board;community engaged research;Community Outreach;community-centered;Comprehensive Cancer Center;Country;Data;design;Development;Diagnosis;Diffusion of Innovation;Education;education research;Educational Activities;Educational Materials;Evaluation;evidence base;experience;Feedback;Florida;Funding;General Population;Goals;handbook;Health;health belief;health equity;Health Professional;Hispanic;Human;improved outcome;Individual;innovation;Institution;Knowledge;Latino;low socioeconomic status;Malignant neoplasm of lung;Malignant neoplasm of pancreas;Malignant neoplasm of prostate;Malignant Neoplasms;Measures;member;men;Mission;Modeling;Multimedia;Pancreas;Persons;Policy Maker;Population;Population Heterogeneity;programs;Prostate;Reporting;Research;Research Personnel;Research Project Grants;Resources;Risk;Scientist;Spanish/English;Technology;Theoretical model;theories;tool;Training;Training Programs;Universities;University of Southern California Norris Cancer Center;Voice;web site;webinar;Work;Writing

PROJECT_TITLE: Community Outreach Core


ADMINISTERING_IC: FD

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: Project narrative (public health relevance statement) Myotonic dystrophy is an inherited neurodegenerative disease that causes progressive muscle weakness, cognitive dysfunction, and sleep disturbance. There is no cure. The purpose of this proposal is to develop novel strategies that will accelerate the discovery of effective treatments.

PI_NAMEs: WHEELER, THURMAN M (contact)

PROGRAM_OFFICER_NAME: NUGENT, BRIDGET

PROJECT_TITLE: Prospective study in myotonic dystrophy to determine extracellular RNA biomarkers


ADMINISTERING_IC: HS

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: NEW YORK

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: PROJECT NARRATIVE (PUBLIC HEALTH RELEVANCY STATEMENT) Chinese immigrants suffer a disproportionately high type 2 diabetes (T2D) burden and have poor health outcomes. They face numerous social determinants barriers to accessing evidence-based diabetes programs, including high rates of poverty and limited English proficiency (LEP), and lack of insurance. This project will provide important evidence on scalable strategies to disseminate and implement evidence-based diabetes interventions in LEP Chinese immigrants with T2D.

PI_NAMEs: HU, LU  (contact)

PROGRAM_OFFICER_NAME: COA, KISHA

PROJECT_TITLE: Implementing an effective Diabetes intervEntion Among Low-income immigrants (IDEAL Study)


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: INDIANAPOLIS

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: RELEVANCE TO PUBLIC HEALTH Dementia is predicted to affect more than 50 million people by the year 2050 and is a leading cause of death. However, there is no cure and more than 400 clinical trials have not proven successful. We believe that immune signaling molecules in the brain causes chronic brain inflammation; therefore, we believe that by being able to monitor the signaling proteins involved would be a viable strategy to stage and grade dementia using a unique set of human-relevant mouse models we have created in preparation for testing in human clinical trials.

PI_NAMEs: MEYER, JASON STEPHEN;SCHULTE, MICHAEL L;TERRITO, PAUL RICHARD (contact)

PROGRAM_OFFICER_NAME: PETANCESKA, SUZANA

PROJECT_TERMS: Acute;Adenosine;Adult;Affect;Affinity;Age;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer’s disease biomarker;Amyotrophic Lateral Sclerosis;Animal Model;antagonist;APP-PS1;Autopsy;Benzamides;Binding;Biodistribution;Biological Assay;Biological Markers;biomarker development;Brain;Caspase;Cause of Death;Cell Death;Cell membrane;Cell Surface Receptors;cell type;Cells;Central Nervous System;Characteristics;Chronic;Clinical Trials;Collaborations;Communication;Coupled;Data;Dementia;Development;Disease;Disease Progression;Dissociation;dosimetry;ecto-nucleotidase;Effectiveness;Encephalitis;Environmental Risk Factor;Epilepsy;Exhibits;Exposure to;extracellular;first-in-human;Gene Expression;Gene Proteins;Generations;Genetic;Genetic Polymorphism;Goals;Human;human induced pluripotent stem cells;IL4 gene;Image;imaging agent;imaging study;Immune;Immune signaling;Impaired cognition;improved;In Vitro;induced pluripotent stem cell;Inflammation;Inflammatory;Inner mitochondrial membrane;Interferon Type II;Interleukin-13;Ion Channel Gating;Kinetics;Ligands;Macrophage;Membrane Proteins;Metabolism;Microglia;Modeling;molecular marker;Molecular Weight;Monitor;mouse model;Mus;Mutation;Nature;Nerve Degeneration;Neurodegenerative Disorders;Neuroglia;neuroinflammation;Neurons;novel;Organ;Outer Mitochondrial Membrane;Oxidative Stress;P2X-receptor;Parkinson Disease;Penetration;Persons;PET/CT scan;Phase;Phenotype;Play;Positron-Emission Tomography;Preparation;protein complex;protein expression;Proteins;Public Health;Purinoceptor;radioligand;Radiopharmaceuticals;receptor;receptor expression;Receptor Signaling;recruit;Reperfusion Injury;Research Personnel;response;Risk;Role;Sensitivity and Specificity;Severity of illness;Signal Transduction;Signaling Molecule;Signaling Protein;Specificity;Testing;Therapeutic;Time;tool;Tracer;Traumatic Brain Injury;treatment response;tripolyphosphate;Women's cohort;Work

PROJECT_TITLE: Targeting P2RX7 Signaling as a Biomarker for ADRD

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AN-Q(55)]


ORG_CITY: CHICAGO

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Hepatic steatosis is a common radiographic “incidental finding” that is overlooked and underreported to patients. We developed a clinical decision support system using machine learning and natural language processing that will prompt reporting to patients and provide ED clinicians risk stratified follow-up care recommendations. Data on both the implementation and effectiveness of our intervention resulting from this trial will inform future use with a goal of ultimately improving diagnostic safety and outcomes for patients with hepatic steatosis.

PI_NAMEs: KONTRICK, AMY V (contact);MCCARTHY, DANIELLE M

PROGRAM_OFFICER_NAME: COSBY, KAREN

PROJECT_TITLE: Improving Diagnostic Safety through STeatosis Identification, Risk stratification, and Referral in the ED (STIRRED)


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Immunotherapy;Neurosciences;Orphan Drug;Radiation Oncology;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: HOUSTON

ORG_NAME: METHODIST HOSPITAL RESEARCH INSTITUTE

ORG_STATE: TX

PHR: Resistance to conventional chemo-radiation and immunotherapy in glioblastoma (GBM) results in uniform lethality by 12-18 months in the majority of patients. Here we propose to demonstrate novel therapeutic potential of drugs termed CDIMs that target NR4A1 and NR4A2 nuclear orphan receptors which drive interacting mesenchymal and immune suppressive tumor microenvironments that promote resistance to standard chemo- radiation and immune checkpoint therapy, respectively. By disrupting NR4A1/2 effects on the tumor microenvironment, CDIMs are expected to have robust anti-tumor activity and potentiate current chemo-radiation or immune based therapies in GBM.

PI_NAMEs: MIKHEEV, ANDREI M;ROSTOMILY, ROBERT C (contact);SAFE, STEPHEN H.

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: Adoptive Transfer;Adult;antagonist;anti-cancer;Automobile Driving;Bioinformatics;bioinformatics tool;Biological Assay;Biology;Cancer Model;candidate identification;Carcinoma;Cell Line;Cell Physiology;Cell Proliferation;Cells;Cessation of life;checkpoint therapy;chemoradiation;Clinical Trials;conventional therapy;cytokine;cytotoxicity;Data;Drug Kinetics;exhaust;exhaustion;Exhibits;Future;Gene Expression;Genes;Genetic;Glioblastoma;Goals;Human;IL8 gene;Immune;Immune checkpoint inhibitor;Immune Evasion;Immune response;Immunooncology;Immunosuppression;Immunotherapy;improved;in vivo;in vivo evaluation;Indoles;Infiltration;Invaded;knock-down;Lead;Ligands;loss of function;Macrophage;Malignant - descriptor;Malignant neoplasm of brain;Malignant Neoplasms;Measures;Mediating;Mesenchymal;Mesenchymal Cell Neoplasm;migration;Modeling;Molecular;multidisciplinary;Mus;Myeloid Cells;Myeloid-derived suppressor cells;neoplastic cell;neuro-oncology;novel;novel strategies;novel therapeutics;NR4A1 gene;NR4A2 gene;Nuclear Orphan Receptor;Orphan Nuclear Receptor Gene;Outcome;Patients;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacologic;Phenotype;pre-clinical;Pre-Clinical Model;Preclinical Testing;Production;programmed cell death ligand 1;programs;Proliferating;Property;radiation resistance;Radiation therapy;receptor;receptor expression;Receptor Inhibition;Regulation;Regulatory T-Lymphocyte;Resistance;response;Role;self-renewal;Series;Signal Transduction;single-cell RNA sequencing;standard of care;stem cell self renewal;stemness;T cell differentiation;T-Lymphocyte;temozolomide;Testing;Therapeutic;therapy resistant;Toxic effect;treatment response;tumor;tumor growth;tumor microenvironment;tumor-immune system interactions;Tumorigenicity;TWIST1 gene

PROJECT_TITLE: “Pharmacologic targeting of NR4A1 and NR4A2 to activate glioblastoma treatment response”

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Dental, Oral, and Craniofacial Disease;Emergency Care;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Pediatric;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: RICHMOND

ORG_DEPT: DENTISTRY

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: Narrative To improve oral health and reduce health inequities, it is essential to address structural barriers that impede access and use of dental services; on July 1, 2021, the Virginia Medicaid program expanded dental benefits, enabling 800,000+ adults to access comprehensive dental services. The research plan of this career development award aims to evaluate the multi-level impact of this large-scale dental policy change on access and use of dental care among adults and children and isolate the role of dental policy in addressing oral health disparities using advanced data science approaches. The resulting findings from this work will fill critical research gaps, generate actionable evidence to strengthen existing and new policies, inform programmatic decisions to improve oral health equity and support NIDCR's strategic goal of advancing oral health for all.

PI_NAMEs: NAAVAAL, SHILLPA  (contact)

PROGRAM_OFFICER_NAME: THIRUMANGALATHU, SHOBA

PROJECT_TERMS: access disparities;Accident and Emergency department;Address;Adult;Advisory Committees;analytical method;career;career development;Child;Child Health;Clinical Investigator Award;Communities;Complex;complex data;Comprehensive Dental Care;cost;County;Data;Data Science;Data Set;Data Sources;Dental;Dental Care;Dental Care for Children;Dental Scaling;Development;Development Plans;Disparity;disparity reduction;econometrics;Economics;Emergency department visit;Emergency Situation;Enrollment;Ensure;Environment;ethnic minority;Ethnic Origin;evidence base;experience;Face;Family;federal poverty level;Foundations;Goals;Health;Health Benefit;Health Disparities Research;health disparity;health equity;health inequalities;Health Policy;Health Services;Health Services Accessibility;Health Services Research;Healthcare;improved;Individual;insight;Institution;Insurance;Interruption;K-Series Research Career Programs;Knowledge;Laws;Link;Low income;Measures;Medicaid;Mentors;Mentorship;Methods;Minority Groups;Mouth Diseases;multidisciplinary;National Institute of Dental and Craniofacial Research;Natural experiment;Oral health;Outcome;Outcomes Research;Parents;Personal Satisfaction;Policies;Policy Research;Population;Preventive;Preventive service;Privatization;Productivity;programs;Quasi-experiment;Race;racial minority;Research;Research Personnel;Research Project Grants;Research Support;Resources;Role;Rural;Savings;Series;Service delivery model;service utilization;Services;skill acquisition;skills;social factors;socioeconomic disparity;Solid;Source;State Children's Health Insurance Program;Structure;success;System;Time;Tooth Diseases;Training;treatment services;Underinsured;Uninsured;Virginia;Vision;Visit;Work

PROJECT_TITLE: The role of comprehensive adult Medicaid dental benefit in improving oral health and reducing disparities among adults and children

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: PROJECT NARRATIVE The collaboration between New Mexico State University (NMSU) and Fred Hutchinson Cancer Center (Fred Hutch) with its 20-year history of innovative and impactful partnership seeks to further support cancer research at NMSU, increase participation in health disparities research at Fred Hutch, and recruit, train and support underrepresented students and Early Stage Investigators in cancer research careers. The Partnership seeks to deliver outreach and education on cancer to underserved populations in the US southwest and Pacific northwest.

PI_NAMEs: HEFFNER, JAIMEE ;MARIN, MERRANDA ;SIMON, JULIAN  (contact);UNGUEZ, GRACIELA ALEXANDRA

PROGRAM_OFFICER_NAME: RODRIGUEZ, LARITZA MARIA

PROJECT_TERMS: Address;Adopted;Advanced Malignant Neoplasm;anti-cancer research;Basic Science;Cancer Center;cancer education;cancer health disparity;Cancer health equity;cancer prevention;Cancer Research Project;career;Clinical;Collaborations;college;Communities;community collaboration;community engaged research;community engagement;community organizations;Comprehensive Cancer Center;Dedications;design;Education;Education and Outreach;education research;Environment;Equity;equity, diversity, and inclusion;Evaluation;Exclusion;experience;Faculty;Funding;Future;Goals;Graduate Degree;Health;Health Disparities Research;health disparity;health disparity populations;Health education;Health equity research;Health Sciences;improved;Individual;innovation;Institution;Internships;Joints;Knowledge;Laboratories;Malignant Neoplasms;meetings;member;Mentors;Mission;New Mexico;outreach;outreach program;Pacific Northwest;Participant;population health;Population Sciences;Process;programs;Public Health;Publications;Recording of previous events;recruit;Reduce health disparities;Research;Research Personnel;Research Project Grants;Research Support;Resource Sharing;Resources;Science;Scientist;Southwestern United States;Students;success;Time;Training;undergraduate student;Underrepresented Populations;Underrepresented Students;Underserved Population;Universities;university student;Voice;Washington;Work

PROJECT_TITLE: 2/2 Partnership for the Advancement of Cancer Research: NMSU & Fred Hutch


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer

PI_NAMEs: SIMON, JULIAN  (contact)

PROJECT_TERMS: Advanced Malignant Neoplasm;Advisory Committees;anti-cancer research;Budgets;Cancer Center;cancer health disparity;Cancer Research Project;Clinical;Communication;Communities;community collaboration;community organizations;community partners;COVID-19 pandemic;Development;Education and Outreach;education research;Effectiveness;Electronic Mail;Ensure;Environment;Evaluation Research;Exclusion;experience;Feedback;Fostering;Future;global health;Goals;health equity;Health Sciences;improved;Individual;Infrastructure;innovation;insight;Institution;interest;Leadership;learning community;Link;Lived experience;Location;Logistics;Malignant Neoplasms;meetings;member;Methods;Mission;National Cancer Institute;New Mexico;outreach;outreach program;pandemic disease;Participant;Persons;population health;Process;Productivity;Program Efficiency;programs;Recording of previous events;Reduce health disparities;Research;research faculty;Research Project Grants;Resource Allocation;Resources;Scientist;Source;Structure;Students;Study Section;System;Technology;Telephone;Time;undergraduate student;Underrepresented Populations;Universities;Videoconferencing;Washington;Work

PROJECT_TITLE: Administrative Core


PI_NAMEs: PETERSON, KAREN R (contact)

PROJECT_TERMS: Academic support;Address;Advanced Malignant Neoplasm;Affect;Agreement;anti-cancer research;Area;Cancer Biology;Cancer Center;cancer health disparity;career;career development;Cessation of life;cohort;Collaborations;Communication;Communities;Conflict (Psychology);conflict resolution;Consultations;COVID-19 pandemic;Development;Education;Educational process of instructing;Educational workshop;Environment;Evaluation;Event;Exclusion;expectation;experience;Face;Faculty;faculty mentor;faculty support;flexibility;Fostering;Foundations;Grant;Growth;Heart;higher education;improved;Individual;Institution;Knowledge;Longevity;Malignant Neoplasms;Manuscripts;meetings;member;Mentors;Modeling;Monitor;New Mexico;outreach;pandemic disease;pandemic stressor;Participant;peer;Preparation;Process;Production;Research;Research Personnel;Resource Sharing;Resources;satisfaction;Scientist;Services;skills;Societies;student mentoring;Students;success;System;Teacher Professional Development;Time;Training;Travel;undergraduate student;Universities;Vocational Guidance;Work;Writing

PROJECT_TITLE: Core 1: Resource for AcademIc SuccEss (RAISE)


ADMINISTERING_IC: AA

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Prevention;Substance Misuse

ORG_CITY: SAN FRANCISCO

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative This study, entitled “BEATS: Binge drinking Ecological Antecedents with Transdermal alcohol monitoring Study,” will enroll 100 sexually-active adults who binge drink alcohol and assess real-time antecedents for binge-drinking and binge-drinking associated sexual behaviors using real-time assessments during a 30-day follow-up. Participants will also wear a wrist monitor that will track alcohol consumption continuously for 30 days. Data from the assessments and monitor will be analyzed using machine learning approaches to develop algorithms that predicts binge drinking (aim 1) and binge-drinking associated sexual behaviors (aim 2), while data on the feasibility and acceptability of these procedures will be examined for this population (aim 3).

PI_NAMEs: SANTOS, GLENN-MILO  (contact)

PROGRAM_OFFICER_NAME: FREEMAN, ROBERT

PROJECT_TERMS: acceptability and feasibility;Acute;Address;Adult;Age;AIDS prevention;alcohol abuse therapy;Alcohol consumption;alcohol intervention;alcohol monitoring;alcohol use disorder;Alcohols;American;Behavior;behavior prediction;Behavior Therapy;Behavioral;binge drinker;binge drinking;Biosensor;Cellular Phone;Cessation of life;contextual factors;Data;Development;drinking;drinking behavior;Ecological momentary assessment;economic cost;effective intervention;Enrollment;Environment;Epidemic;Event;experience;follow-up;Future;Heavy Drinking;Heterosexuals;high risk;HIV;HIV Infections;HIV risk;Individual;Intervention;Laboratory Research;Link;Machine Learning;Measurement;Measures;men;men who have sex with men;Methods;Monitor;Multiple Partners;novel;Outcome;Participant;Patient Self-Report;Pattern;personalized intervention;Pharmacotherapy;Population;prediction algorithm;Prevalence;Prevention strategy;Procedures;Psychosocial Factor;Public Health;real time monitoring;recruit;Reporting;Research Design;Risk Behaviors;risk prediction;risk prediction model;San Francisco;Sex Behavior;sexual HIV transmission;sexual risk behavior;sexually active;Sexually Transmitted Diseases;surveillance data;systematic review;Technology;Testing;therapy development;Time;treatment program;Unsafe Sex;Variant;Woman;Wrist

PROJECT_TITLE: BEATS: Binge drinking Ecological Antecedents with Transdermal alcohol monitoring Study.

STUDY_SECTION: AA

STUDY_SECTION_NAME: Epidemiology, Prevention and Behavior Research Study Section[AA-2]


PI_NAMEs: SULLIVAN, LUCAS BRYAN (contact)

PROJECT_TERMS: Acute;Address;Advanced Malignant Neoplasm;anti-cancer research;Aspartate;Automobile Driving;Bioinformatics;Biological;Biometry;cancer cell;Cancer Model;Cancer Patient;cancer type;career;career development;Cell Physiology;Cell Proliferation;Cells;Cellular Metabolic Process;Characteristics;Chronic;Citric Acid Cycle;Collaborations;community engagement;Community Health;Complex;Data;Data Analyses;Data Set;Defect;Dependence;design;education research;Educational Status;Educational workshop;Electron Transport;Environment;Enzymes;Epigenetic Process;epigenomics;Ethnic Origin;experience;Face;Fostering;Gene Expression Process;Genetic Transcription;Genotype;Health;health disparity;Human;Hypoxia;Impairment;improved;improved outcome;inhibitor;Institution;Interdisciplinary Study;Intervention;Intrinsic factor;Joints;Knowledge;loss of function mutation;Machine Learning;machine learning model;Malignant Neoplasms;Measurement;meetings;member;Mentors;Metabolic;metabolic abnormality assessment;metabolic phenotype;Metabolism;Metadata;Mitochondria;Modeling;multidisciplinary;mutant;Mutation;next generation;novel;novel therapeutic intervention;Nutrient;Oncogenic;Outcome;outreach;Oxygen;Pathway Analysis;Patients;Pilot Projects;pressure;prevent;Process;Proliferating;protein expression;Proteins;Proteomics;proteostasis;Race;Reactive Oxygen Species;Reproducibility;Research;research data dissemination;Research Personnel;Research Support;Resources;response;restoration;Science;Scientist;Statistical Methods;statistics;student training;Students;success;Succinate Dehydrogenase;Succinate dehydrogenase (ubiquinone);Supporting Cell;System;targeted cancer therapy;Techniques;Time;Tissues;Training;transcriptomics;tumor;tumor metabolism;tumor progression;Tumor Suppressor Proteins;tumorigenesis;Underrepresented Students;underserved community

PROJECT_TITLE: Project 2: Systemic Understanding of Cellular Mechanisms of Metabolic Adaptations in Cancer


NIH_SPENDING_CATS: Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Clinical Research;Dietary Supplements;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Natural Products;Nutrition;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: GREENLEE, HEATHER  (contact)

PROJECT_TERMS: Adult;Advanced Malignant Neoplasm;anti-cancer research;Ascorbic Acid;Back;Behavioral Research;Biological Availability;Biological Markers;Blood;Cancer Center;cancer health disparity;cancer prevention;cancer recurrence;cancer risk;Cardiometabolic Disease;career;Carotenoids;Chlorophyll;Chronic Disease;Collaborations;Communities;Community Actions;community based research;community collaboration;comorbidity;Computer software;Consumption;cooking;County;Cross-Over Trials;design;Diet;dietary;Dietary Intervention;Dietary Practices;Digestion;Dryness;education research;Educational Curriculum;Educational Intervention;Effectiveness;effectiveness testing;Environment;Evaluation;evidence base;Exclusion;experience;faculty mentor;Folic Acid;Food;fruits and vegetables;Funding;Future;graduate student;Health;Health Sciences;Hispanic;human centered design;improved;In Vitro;Information Systems;Infrastructure;Intake;Intervention;Knowledge;Latinx;Lived experience;Low income;Malignant Neoplasms;Measurable;meetings;member;Mentors;meter;Methods;Mexican;Modeling;Modernization;New Mexico;nutrition;Outcome;Outcome Measure;outreach;Participant;Phytochemical;Phytonutrients;Pilot Projects;Plants;population health;portion control;Prevention education;Preventive;primary outcome;Process;Program Evaluation;programs;Public Health;Public Health Education;Randomized;Recipe;recruit;Research;Research Personnel;Resources;Risk;Scientist;secondary outcome;Self Efficacy;Services;Spanish/English;Spottings;Students;success;systems research;Testing;Time;Tocopherols;Training;Translating;trial design;Universities;Variant;Vitamin B Complex;vulnerable community;Vulnerable Populations;Waiting Lists

PROJECT_TITLE: Project 3: A Transdisciplinary Approach to Increasing Phytonutrients in New Mexican Diets: A Kitchen-to-Lab-to-Table Model


ORG_CITY: SALT LAKE CITY

ORG_NAME: BLACKROCK MICROSYSTEMS

ORG_STATE: UT

PHR: PROJECT NARRATIVE This project seeks to establish clinical outcome assessments (COAs) to capture the capacity, efficacy, impacts, and perceptions of communication brain computer interfaces (cBCIs) as tools to improve the healthcare and quality of life of those with ALS and their caregivers. To better develop and apply such COAs, we will develop a deep and wide-ranging understanding of (1) the current clinical and scientific landscape surrounding cBCIs, (2) the assessment of their impacts and efficacy, (3) the strengths and weaknesses of current COAs, (4) patient needs and their perceptions of cBCIs, and (5) to evaluate areas for future COA development. By including historical, scientific, and stakeholder-based information in a landscape assessment of COAs for cBCIs in ALS, we can establish a clear pathway toward identification, development, and validation of a precise, accurate, and meaningful measure that will facilitate regulatory approval, reimbursement, and patient access to these transformative technologies.

PI_NAMEs: KELLIS, SPENCER  (contact)

PROGRAM_OFFICER_NAME: MUELLER, CHRISTINE

PROJECT_TITLE: Metrics for Brain Controlled Communication: A comprehensive review of clinical outcome assessments for communication brain computer interfaces in amyotrophic lateral sclerosis


NIH_SPENDING_CATS: Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Lung Cancer;Networking and Information Technology R&D (NITRD);Prevention;Social Determinants of Health;Substance Misuse;Telehealth;Tobacco;Tobacco Smoke and Health

PI_NAMEs: HEFFNER, JAIMEE  (contact)

PROJECT_TERMS: Abstinence;Accounting;Address;Adult;Advanced Malignant Neoplasm;anti-cancer research;arm;Biochemical;Cancer Research Project;career development;Cessation of life;Cigarette;Communities;community advisory board;community engaged approach;community organizations;comparison group;Counseling;culturally appropriate intervention;Data;design;Development;diaries;digital;digital intervention;Disparity;Disparity population;education research;effectiveness testing;efficacy outcomes;Electronic Nicotine Delivery Systems;empowerment;Environment;Equity;Ethnic Origin;Evaluation;experience;Feedback;flexibility;follow-up;Future;Gender Identity;gender minority community;gender minority group;Health;High Prevalence;individualized medicine;innovation;Intervention;Interview;Language;Latinx;Lead;Lived experience;Malignant Neoplasms;Media Intervention;member;Methods;mhealth interventions;Modification;mortality;National Cancer Institute;New Mexico;Nicotine;nicotine user;novel;novel strategies;outreach;Pharmacotherapy;Pilot Projects;pilot trial;Population;Prevalence;Preventable cancer cause;primary outcome;Process;programs;psychologic;queer;Randomized, Controlled Trials;Readiness;recruit;Reduce health disparities;Research;Research Personnel;Research Training;Resources;Risk;satisfaction;Science;secondary outcome;Sex Orientation;Sexual and Gender Minorities;sexual minority group;Smoke;Smoker;smoking cessation;smoking prevalence;Smoking treatment;social media;Spanish;Structure;Students;success;Testing;theories;Tobacco;tobacco abstinence;tobacco cessation intervention;tobacco control;tobacco products;Tobacco use;Tobacco Use Cessation;tobacco user;Training;treatment effect;treatment group;Treatment outcome;treatment research;trend;United States National Institutes of Health;user centered design;Work;young adult

PROJECT_TITLE: Project 4: Culturally‐Tailored, Avatar‐Led mHealth Intervention to Aid Smoking Cessation Among Sexual and Gender Minority Young Adults in New Mexico


NIH_SPENDING_CATS: Cancer;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Hepatitis;Liver Cancer;Liver Disease;Prevention;Rare Diseases

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative  Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality worldwide. HMG-CoA reductase (HMGCR) inhibitors, statins, show high potential in the prevention and treatment of cancer including HCC. We hypothesize that the MYC pathway is suppressed by statins and this is a mechanism by which statins can prevent and treat HCC, both through direct anti-oncogene effects as well as by restoring immune surveillance. We will determine the mechanisms by which statins protect against HCC as well as identify biomarkers that can predict when these agents are most likely to be useful in preventing HC.

PI_NAMEs: FELSHER, DEAN W (contact);VERNA, ELIZABETH CLARICE

PROGRAM_OFFICER_NAME: READ-CONNOLE, ELIZABETH LEE

PROJECT_TERMS: anti-cancer;anti-cancer research;atorvastatin;Biological Markers;biomarker identification;Blood;Cancer Etiology;cancer therapy;carcinogenesis;Cellular Metabolic Process;Cholestasis;Cholesterol;Cirrhosis;Clinical;Clinical Research;Clinical Trials;Cohort Studies;Collaborations;Compensation;Cryptogenic cirrhosis;cytokine;Cytometry;Diagnostic;epidemiology study;Etiology;Fatty Acids;Fibrosis;fighting;Gastroenterology;Glucose;Glutamine;Hepatic;Hepatology;Homeostasis;Human;Hydroxymethylglutaryl-CoA Reductase Inhibitors;imaging agent;Immune;Immune system;Immunologic Markers;Immunologic Surveillance;improved;Inflammation;inhibitor;insight;ionization;Knowledge;Laboratories;Lead;Letters;Libraries;lipid biosynthesis;Lipids;liver cancer model;Liver Cirrhosis;Liver diseases;Malignant Neoplasms;mass spectrometric imaging;Mass Spectrum Analysis;Mediating;Medical Oncology;member;Meta-Analysis;Metabolic;Metabolic Pathway;Metabolism;metabolomics;Modeling;Molecular;mortality;mouse model;MYC gene;National Institute of Diabetes and Digestive and Kidney Diseases;Nature;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;novel;novel therapeutics;Oncology;Oxidative Stress;Oxidoreductase;Pathogenesis;Pathway interactions;patient derived xenograft model;Patients;Pharmaceutical Preparations;Phosphorylation;pre-clinical;prevent;Prevention;Preventive;Preventive therapy;Primary carcinoma of the liver cells;programs;Proliferating;Property;prospective;Publishing;Reporting;Research;Research Personnel;Risk;Risk Reduction;rosuvastatin;Sampling;Series;Signal Transduction;single-cell RNA sequencing;System;Tetanus Helper Peptide;Therapeutic Effect;Transgenic Mice;Transgenic Model;Transgenic Organisms;Travel;tumor;tumor immunology;tumor initiation;tumor progression;Tumor Suppressor Genes;tumorigenesis;United States National Institutes of Health;Work

PROJECT_TITLE: Molecular Mechanisms by which Statins Prevent and Reverse Hepatocellular Carcinoma


NIH_SPENDING_CATS: Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Childhood Obesity;Clinical Research;Nutrition;Obesity;Pediatric;Pediatric Cancer;Physical Activity;Prevention;Rare Diseases;Social Determinants of Health

PI_NAMEs: MENDOZA, JASON A (contact)

PROJECT_TERMS: 11 year old;18 year old;Accelerometer;active lifestyle;Address;Adolescence;Adult;Advanced Malignant Neoplasm;after-school program;Age;American;anti-cancer research;Behavior;behavior change;Body mass index;Cancer Center;cancer risk;cancer type;career development;Cellular Phone;Child;Childhood;Chronic Disease;Clinical;Collaborations;Colorectal Cancer;community academic partnership;community engaged research;Computers;cost;County;design;Diabetes Mellitus;Diet Habits;Disease;Disparity;Education;education research;efficacy evaluation;Electronics;Environment;Epidemic;Evaluation;Facebook;Family;Family member;feasibility testing;fifth grade;Fostering;Fruit;fruits and vegetables;Funding;Goals;graduate student;Guidelines;Health;health disparity;health equity promotion;Health Food;Healthy Eating;healthy lifestyle;Heart Diseases;high body mass index;Hispanic;Hodgkin Disease;Home;Hour;Household;improved;innovation;Institution;Intake;Leisures;leukemia;Life;Life Style;Long-Term Effects;low socioeconomic status;Malignant Breast Neoplasm;Malignant Neoplasms;Mentorship;mortality;New Mexico;nutrition;Obesity;obesity in children;obesity prevention;obesity risk;oral communication;outreach;Overweight;Parents;Physical activity;physical inactivity;Pilot Projects;pilot test;Play;Preparation;Prevalence;Prevention program;Privatization;programs;Protocols documentation;Recommendation;Recreation;recruit;Reduce health disparities;Reporting;Research;Research Project Grants;Risk;school district;Schools;Science;Scientist;sedentary lifestyle;Site;skills;Sleep;social;Stroke;Students;Surveys;Teenagers;Television;Testing;Time;tv watching;undergraduate student;underserved community;Universities;Update;Video Games;Washington;Writing;Yakima Valley

PROJECT_TITLE: Pilot Project 1: H-PACE: Promoting Healthy Living Through Behavior Change


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

PROJECT_TERMS: Accountability;Address;Advanced Malignant Neoplasm;Advisory Committees;American;anti-cancer research;Assessment tool;Cancer Center;cancer health disparity;Cancer health equity;career;Collaborations;Communication;Communities;community academic partnership;Community Actions;community engagement;Consensus;Consultations;Data;Data Analyses;data collection methodology;Decision Making;Education;Effectiveness;Ensure;Environment;Equity;equity, diversity, and inclusion;Evaluation;Evaluation Methodology;Evaluation Research;evidence base;Faculty;Faculty Recruitment;Familiarity;Funding;Goals;Grant;health equity;Impact evaluation;implementation evaluation;improved;Individual;innovation;Institution;instrument;Interview;Lead;Logic;Malignant Neoplasms;Measures;meetings;member;Modeling;New Mexico;Outcome;Outcome Assessment;Outcome Measure;outreach;Pacific Northwest;Participant;Policies;Process;Productivity;Program Evaluation;programs;Publications;Questionnaires;Recommendation;Regional Cancer;Reporting;Request for Applications;Research;Research Project Grants;Science;Scientist;Southwestern United States;Students;Study Section;success;Suggestion;Surveys;synergism;Techniques;Training;translational health science;Underrepresented Populations;Underserved Population;United States National Institutes of Health;Universities;Washington;Work

PROJECT_TITLE: Planning & Evaluation Core


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Drug Abuse (NIDA only);Methamphetamine;Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: Aurora

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Methamphetamine (MA) is a highly addictive drug that has both rewarding and aversive effects. We recently discovered that a receptor called the trace-amine associated receptor 1 (TAAR1) mediates MA aversion and protects against MA intake. By using genetic tools and electrophysiology, this project will identify how MA activation of TAAR1 produces aversion and reduces MA intake, which could lead to the identification of a new class of therapeutics for MA addiction.

PI_NAMEs: INGRAM, SUSAN L (contact);PHILLIPS, TAMARA J.

PROJECT_TERMS: Ablation;Address;Agonist;Amines;Behavior;Behavioral;behavioral study;Bilateral;Brain;Breeding;Cell Nucleus;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Consumption;Data;Dependence;Disease;Dopamine;dopamine transporter;dopaminergic neuron;Dorsal;Dose;Drug Use Disorder;effective therapy;Electrophysiology (science);excitatory amino acid transporter 3;experience;extracellular;G-Protein-Coupled Receptors;Genetic;Genotype;Glutamate Receptor;Glutamate Transporter;Glutamates;Goals;Habenula;in vivo;Injections;Intake;Knock-in;Knock-in Mouse;Label;Laboratories;Lateral;Lesion;Mediating;Mediation;Membrane;Membrane Transport Proteins;Methamphetamine;methamphetamine action;Methamphetamine dependence;methamphetamine effect;methamphetamine use;monoamine;Motivation;Mus;neural circuit;Neurons;neurotransmitter release;optogenetics;patch clamp;Pathway interactions;Pattern;Pharmaceutical Preparations;Physiological;presynaptic;Presynaptic Terminals;Property;Publishing;receptor;Regulation;Research;retrograde transport;Rewards;Risk Reduction;Role;Serotonin;Serotonin Agonists;serotonin transporter;Signal Transduction;Slice;Synapses;Synaptic plasticity;Testing;Therapeutic;tool;Tracer;Ventral Tegmental Area;Wild Type Mouse;With laterality

PROJECT_TITLE: Role of lateral habenula in methamphetamine TAAR1-mediated synaptic plasticity and aversion

STUDY_SECTION: MCNP

STUDY_SECTION_NAME:
Molecular and Cellular Neuropharmacology Study Section
[MCNP]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

PROJECT_TERMS: Academic support;Advanced Malignant Neoplasm;Advisory Committees;anti-cancer research;Area;Biological Sciences;Biomedical Research;Cancer Biology;cancer health disparity;Cancer health equity;Career Mobility;Collaborations;Communication;Communities;Creativeness;design;Development;Discipline;Education;education research;Educational Activities;Effectiveness;Environment;equity, diversity, and inclusion;Ethnic Population;Evaluation;Exclusion;experience;Feedback;formative assessment;Funding;Future;Goals;graduate student;Grant;Health;Health Disparities Research;health disparity;health equity;improved;Individual;innovation;Institution;interest;Internships;Joints;Knowledge;learning community;Malignant Neoplasms;Measures;meetings;member;Motivation;Names;next generation;Participant;population health;Positioning Attribute;Process;Program Evaluation;programs;Public Health;public health research;Public Health Schools;Recommendation;Research;Research Personnel;Research Project Grants;Research Support;Resources;response;role model;Science;Scientist;skills;social group;Students;success;synergism;tool;Training;Training and Education;Training Programs;undergraduate student;underserved community;Universities;Washington;Work

PROJECT_TITLE: Research Education About Cancer and Health (REACH) Core


ORG_CITY: EAST LANSING

ORG_NAME: HENRY FORD HEALTH + MICHIGAN STATE UNIVERSITY HEALTH SCIENCES

ORG_STATE: MI

PHR: Narrative It became well known that the immune suppressive niche inside the tumor microenvironment (TME) accounts for tumor immune escape and progression, in which the regulatory T cells (Tregs) play an important role. Vacuolar protein sorting 72 homolog (VPS72), a histone chaperone that recognizes and exchanges histone H2A.Z for standard histone H2A. In the proposed studies, we will use gene deletion mouse models to determine the role of VPS72 and H2AZ in Treg cell maintenance, stability, and function in the tumor. Results from the proposed study will not only enhance our understanding of Treg biology but will also facilitate the development of more efficient Treg-based intervention strategies for cancer treatment.

PI_NAMEs: FANG, DEYU ;MI, QING-SHENG  (contact);ZHOU, LI

PROGRAM_OFFICER_NAME: ZAMISCH, MONICA

PROJECT_TERMS: Age;Amino Acids;anti-PD-1;antitumor effect;ATAC-seq;Autoimmune Diseases;Biological Process;Biology;cancer immunotherapy;cancer therapy;Cell Lineage;Cell Maintenance;Cell Physiology;Cell Survival;Cells;Cellular biology;Chromatin;chromatin remodeling;Chromatin Structure;Cleavage Under Targets and Release Using Nuclease;cytokine;Development;Epigenetic Process;epigenetic regulation;Event;experience;fitness;forkhead protein;FOXP3 gene;Gene Deletion;Genetic Transcription;Glucose;Histone H2A;Histones;Homeostasis;Homologous Gene;Hypoxia;Immune;immune checkpoint blockade;immune function;immunoregulation;Immunosuppression;Immunotherapy;improved;In Vitro;in vivo;Individual;Infiltration;insight;Interruption;Intervention;Knock-out;Knockout Mice;Malignant Neoplasms;Mediating;Melanoma;Melanoma Tumor;mitochondrial metabolism;Modeling;Molecular;Molecular Chaperones;mouse model;multiple omics;Mus;neoplastic cell;Oncogenes;Organ;overexpression;Pathway interactions;Peripheral;Phenocopy;Play;Procedures;Protein Isoforms;Proteins;Regulation;Regulatory T-Lymphocyte;Research;Role;Signal Pathway;single cell ATAC-seq;single-cell RNA sequencing;Stress;success;synergism;T-Cell Development;Testing;Thymus Gland;transcriptome sequencing;Transplantation;tumor;Tumor Escape;Tumor Immunity;tumor immunology;tumor microenvironment;Tumor Promotion;Vacuolar Protein Sorting;Variant;Work

PROJECT_TITLE: VPS72 controls Treg cell stability and adaptation to tumor microenvironment

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BTC-Q(80)S]


NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Clinical Research;Colorectal Cancer;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

PI_NAMEs: MCDOUGALL, JEAN ALISON (contact)

PROJECT_TERMS: Active Learning;Address;Advanced Malignant Neoplasm;Affect;American Indians;anti-cancer research;Behavior;Cancer Control;cancer education;Cancer Etiology;cancer prevention;colorectal cancer screening;Communities;community academic partnership;Community Actions;community based participatory research;community collaboration;community engaged research;community engagement;Community of Practice;community organizations;community partners;community partnership;community-centered;Country;COVID-19;COVID-19 outbreak;COVID-19 pandemic;Decision Making;Detection;Development;diversity and inclusion;E-learning;Education;Educational workshop;Elements;Ensure;Environment;Equity;Evaluation;evidence base;Evidence based program;experience;Faculty;Fostering;Funding;Geographic Locations;health equity;Health Insurance;Healthy Eating;healthy lifestyle;high school;Hispanic;improved;Individual;Inequity;Infrastructure;Intervention;Knowledge;Latinx;Learning;lens;low health literacy;Low income;Malignant Neoplasms;marginalized community;Measures;Medically Underserved Area;member;Mexico;Navajo;New Mexico;Outcome;outreach;Outreach Research;Persons;Pilot Projects;Policy Making;Population;Poverty;Prevention;Prevention education;Process;Research;Research Activity;research in practice;Research Methodology;Research Project Grants;Research Training;rural underserved;Science;screening program;Series;Services;social;social media;Spanish/English;Students;Training;Training and Education;Trust;Underserved Population;Vaccination;Voice;Washington;Work

PROJECT_TITLE: Outreach Core


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Cervical Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Emerging Infectious Diseases;HIV/AIDS;Health Services;Infectious Diseases;Prevention;Rare Diseases;Tuberculosis;Women's Health Research

ORG_CITY: NAIROBI CITY

ORG_COUNTRY: KENYA

ORG_FIPS: KE

ORG_NAME: KENYA MEDICAL RESEARCH INSTITUTE (KEMRI)

PHR: Project Narrative: In partnership, KEMRI-CCR–PHRD and LVCT Health (lvcthealth.org) have organized a consortium of scientists and clinicians with expertise in cervical cancer and HIV prevention, care and treatment and the conduct of multi- site clinical trials, behavioral science and propose to join the UG1 as a Network clinical trial site.

PI_NAMEs: MUGO, NELLY RWAMBA (contact);NGURE, KENNETH

PROGRAM_OFFICER_NAME: FRECH, MARIA SILVINA

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Africa;AIDS prevention;Area;base;Behavioral;Behavioral Research;Behavioral Sciences;burden of illness;Cancer Control;Cancer Etiology;Cancer Prevention Intervention;care providers;Caring;CCR;cervical cancer prevention;Cervical Cancer Screening;Clinic;Clinical;clinical care;Clinical Research;Clinical Trials;Clinical Trials Network;clinically significant;Communities;County;data standards;Dose;Eastern Africa;Eligibility Determination;Enrollment;experience;Feasibility Studies;Foundations;Funding;Goals;Gynecologist;Health;Health care facility;Health Personnel;Health Services Accessibility;HIV;HIV Infections;HIV/TB;Hospitals;Human Papillomavirus;implementation evaluation;implementation research;implementation science;improved;Inequity;Infrastructure;insight;International;Joints;Kenya;Knowledge;Laboratories;Leadership;Malignant neoplasm of cervix uteri;member;Morbidity - disease rate;mortality;Multi-Institutional Clinical Trial;National Cancer Institute;Newly Diagnosed;Nongovernmental Organizations;Observational Study;Operations Research;Participant;Persons;Policy Maker;Positioning Attribute;pre-exposure prophylaxis;premalignant;Prevention Guidelines;Prevention Research;programs;protocol development;Protocols documentation;Provider;Public Health;Public Hospitals;randomized, clinical trials;recruit;Reporting;reproductive;Reproductive Health;Research;Research Design;Research Personnel;Research Priority;research study;Resources;response;Rural;Scientist;screening;Screening for cancer;screening services;service programs;Site;social;Southern Africa;Standardization;System;Techniques;Testing;Thermal Ablation Therapy;Training;treatment optimization;treatment program;treatment services;Universities;uptake;urban setting;Visit;Vulnerable Populations;Washington;Woman;Women's mortality;women's prevention;Work;working group

PROJECT_TITLE: KEMRI-PHRD UG1 CASCADE NETWORK UNIT: CERVICAL CANCER PREVENTION FOR WOMEN LIVING WITH HIV RESEARCH


ADMINISTERING_IC: DC

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE This project will improve our understanding of how the brain’s motor system interacts with its sensory systems via the cerebellum as we plan and produce speech. It will employ state-of-the-art non-invasive, ultra-high field functional magnetic resonance imaging to provide maps of brain activity during speaking tasks in unprecedented detail. The foundational knowledge gained through this project is expected to lead to new insights about the mechanisms underlying speech disorders.

PI_NAMEs: BOHLAND, JASON W (contact)

PROGRAM_OFFICER_NAME: KOPF, LISA MARIE

PROJECT_TERMS: Acceleration;Acoustics;Adult;Anatomy;Area;Attenuated;Auditory;Auditory area;auditory feedback;Benchmarking;Biological Models;Brain;Brain Mapping;Brain region;Cell Nucleus;Cerebellar Cortex;cerebellar lesion;Cerebellum;Code;Complex;Computer Models;Data;design;Diagnosis;Disfluent;Electrocorticogram;Electroencephalography;Electrophysiology (science);Evoked Potentials;Experimental Designs;experimental study;Feedback;Functional Imaging;Functional Magnetic Resonance Imaging;Future;Goals;GRB10 gene;Human;improved;Individual;individual variation;Influentials;insight;interest;Intervention;Investigation;Knowledge;Learning;lens;Lesion;Link;Lobule;Magnetic Resonance Imaging;Magnetoencephalography;Maps;Measurement;Measures;Mediating;Methods;Modeling;Modernization;Monitor;Motor;motor control;Motor Cortex;motor learning;Motor output;Movement;Nature;neural;Neurobiology;neuroimaging;non-verbal;Output;Participant;Pathway interactions;Pattern;personalized approach;Persons;Phonetics;phonology;predictive modeling;Primates;Process;Production;Readiness;recruit;Research;Resolution;response;Role;Sampling;Sensory;sensory cortex;sensory feedback;sensory system;Series;Signal Transduction;sound;Specificity;Speech;Speech Disorders;Structure of superior temporal sulcus;Stuttering;Superior temporal gyrus;System;Techniques;Testing;Thalamic structure;theories;tool;Uncertainty

PROJECT_TITLE: High-resolution functional imaging of speech-induced sensory modulation

STUDY_SECTION: MFSR

STUDY_SECTION_NAME: Motor Function, Speech and Rehabilitation Study Section[MFSR]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Orphan Drug;Pancreatic Cancer;Rare Diseases

ORG_CITY: OKLAHOMA CITY

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PHR: Optimal resection of pancreatic adenocarcinoma is of vital importance to the improved care for patients. Our proposal will test the safety of a tumor targeted contrast agent, VD-ZW800C, with MSOT or NIR-fluorescent imaging to improve surgical resection.

PI_NAMEs: JAIN, AJAY ;MCNALLY, LACEY R (contact)

PROGRAM_OFFICER_NAME: LIN, CHARLES

PROJECT_TERMS: Address;Adjuvant Chemotherapy;Adverse effects;Area;Benchmarking;Benign;Binding;Biodistribution;Biological Markers;Blood;Blood Proteins;Blood Vessels;chemotherapy;Clinical;clinical translation;Clinical Trials;Contrast Media;Data;deoxyhemoglobin;Desmoplastic;Detection;Development;Devices;Dose;Drug Kinetics;Dyes;Excision;extracellular;Fibrosis;Fluorescence;fluorescence imaging;Formulation;Freezing;Future;Generations;Goals;Head;Heterogeneity;Human;image guided;Image-Guided Surgery;imaging modality;imaging probe;Imaging technology;improved;in vivo;Inflammation;innovation;Label;Laboratories;Maleimides;Malignant - descriptor;Malignant neoplasm of pancreas;Malignant Neoplasms;Mammary Neoplasms;Measures;meter;Methods;Microscopic;Modeling;Molecular;Molecular Probes;Monoclonal Antibodies;Mus;Near-infrared optical imaging;Neoadjuvant Therapy;No-Observed-Adverse-Effect Level;Non-Malignant;Oncopig;Operative Surgical Procedures;optoacoustic tomography;Oxyhemoglobin;Pancreas;Pancreatic Adenocarcinoma;pancreatic cancer patients;Pancreatitis;Pathology;Patient Care;Patients;Peptides;Peripheral;Pharmacodynamics;Phase;phase II trial;Positive Lymph Node;pre-clinical;preclinical development;Procedures;Radiation therapy;receptor expression;Reporter;Reporting;Resectable;Resolution;Risk;Safety;safety assessment;safety testing;Sampling;scale up;Sensitivity and Specificity;Signal Transduction;Specificity;surgical risk;Tail;targeted imaging;Testing;time use;Tissues;Toxic effect;Toxicology;Translating;tumor;Tumor Tissue;Work

PROJECT_TITLE: Development of contrast agents to facilitate image-guided surgery

STUDY_SECTION: IPCA

STUDY_SECTION_NAME: Imaging Probes and Contrast Agents Study Section[IPCA]


NIH_SPENDING_CATS: Behavioral and Social Science;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Complementary and Integrative Health;Dissemination and Implementation Research;Drug Abuse (NIDA only);Networking and Information Technology R&D (NITRD);Opioid Misuse and Addiction;Opioids;Pain Research;Prevention;Substance Misuse;Telehealth

ORG_DEPT: PSYCHIATRY

PHR: PROJECT NARRATIVE The US is facing a “twin epidemic” with dual crises of chronic pain and opioid overdoses, and despite national efforts to reduce opioid prescribing and improve non-opioid pain management, opioid overdoses are increasing, including from prescription opioids, and uptake of evidence- based nonpharmacological pain treatment approaches remains low. More effectively treating pain with non-opioid strategies is key, but low motivation and logistical barriers have interfered with many patients transitioning from long term opioid therapy to other evidence-based treatments. The proposed study will aim to address both of these barriers by developing and evaluating a Motivational Interviewing (MI) and Contingency Management (CM) intervention aimed at increasing readiness to reduce opioid use and utilize non-opioid, evidence-based CP interventions among individuals displaying risk on LTOT.

PI_NAMEs: CROUCH, TAYLOR BERENS (contact)

PROGRAM_OFFICER_NAME: SU, SHELLEY

PROJECT_TERMS: 3-Dimensional;acceptability and feasibility;addiction;Addictive Behavior;Address;Adherence;Adult;American;Area;barrier to care;behavior change;Behavior Therapy;Behavioral;career;chronic pain;chronic pain management;chronic pain patient;Clinical;Clinical Medicine;Clinical Trials;Cognitive Therapy;Complex;computer human interaction;Computer software;computerized;contextual factors;contingency management;Control Groups;Country;Crutches;Dependence;Development;Diabetes Mellitus;Doctor of Philosophy;Education;effective therapy;eHealth;Enabling Factors;Epidemic;evidence base;Evidence based intervention;Evidence based treatment;Focus Groups;follow-up;General Practitioners;Goals;Health;Health behavior;implementation science;Improve Access;improved;Individual;innovation;interest;Intervention;Interview;Life;Medical Research;medical specialties;Mentors;Motivation;motivational enhancement therapy;non-opioid analgesic;Nonpharmacologic Therapy;novel vaccines;nutrition;Opioid;opioid epidemic;opioid overdose;opioid tapering;opioid therapy;opioid use;opioid use disorder;Outcome;Output;Overdose;Pain;pain behavior;Pain management;patient oriented;patient response;Patient Self-Report;Patients;Pharmaceutical Preparations;Physical therapy;pilot trial;Populations at Risk;Positioning Attribute;prescription opioid;prevent;Process;programs;prototype;Provider;Psychologist;Quality of life;randomized, clinical trials;Readiness;Records;recruit;Research;Research Personnel;Risk;Risk Behaviors;Sampling;satisfaction;Science;Self Efficacy;Self Management;Structure;System;systemic barrier;Testing;theories;Training;treatment center;Twin Multiple Birth;uptake;usability;virtual

PROJECT_TITLE: Addressing the “Readiness Gap:” An eHealth Intervention to Increase Patient Motivation for Evidence-Based Chronic Pain Interventions and Reduced Opioid Reliance

STUDY_SECTION: BMHO

STUDY_SECTION_NAME: Biobehavioral Medicine and Health Outcomes Study Section[BMHO]


ADMINISTERING_IC: MD

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Pediatric;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: BATON ROUGE

ORG_NAME: LSU PENNINGTON BIOMEDICAL RESEARCH CTR

ORG_STATE: LA

PHR: Narrative African American children engage in low amounts of activity, placing them at risk for health disparities as they age. African American fathers may be instrumental in helping to promote physical activity in their children. The current proposal is designed to use community-engaged research methods to develop a physical activity intervention for children in which their fathers are the agents of change, and to determine the feasibility of implementing this intervention.

PI_NAMEs: NEWTON, ROBERT LEE (contact)

PROGRAM_OFFICER_NAME: BARKSDALE, CRYSTAL

PROJECT_TERMS: 10 year old;Accelerometer;actigraphy;active control group;Address;Adult;Affect;African American;Age;Area;Attention;Behavior;behavior change;Behavior Therapy;Child;Child Rearing;Chronic Disease;Communities;community engaged research;Coronary heart disease;design;Diabetes Mellitus;Dietary intake;Effectiveness of Interventions;Elements;Empirical Research;Environment;Environmental Risk Factor;Ethnic Origin;Exercise;exercise intervention;experience;Face;Family;Fathers;Focus Groups;Future;Generations;Health;Health behavior;health disparity;High Prevalence;high risk;Hypertension;implementation intervention;Individual;information gathering;Intervention;Intervention Studies;Knowledge;Light;Measures;men;modifiable risk;Mothers;Obesity;Parents;Participant;Phase;Physical activity;Play;Populations at Risk;Process;programs;Protocols documentation;Qualitative Research;racism;Randomized;randomized, clinical trials;Recommendation;recruit;Reporting;Research;Research Design;Research Methodology;Resources;Risk;Risk Factors;Role;role model;satisfaction;Schedule;secondary outcome;Self Efficacy;Shapes;skills;social;social health determinants;socioeconomics;Stroke;System;treatment arm;treatment response;walkability

PROJECT_TITLE: Fathers and Children Exercising Together (FACEiT)

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


NIH_SPENDING_CATS: Bioengineering;Cancer;Cancer Genomics;Clinical Research;Colorectal Cancer;Digestive Diseases;Genetic Testing;Genetics;Human Genome;Liver Cancer;Liver Disease;Lung;Lung Cancer;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Rare Diseases;Stomach Cancer

ORG_CITY: LOS ANGELES

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE This project will develop and validate an MCED test for the early detection and localization of colon/gastric/liver/lung cancers. If successful, it will be transformative in fighting against these types of cancer, and benefit human kind. 1

PI_NAMEs: BRESALIER, ROBERT S;LI, WENYUAN ;ZHOU, XIANGHONG JASMINE (contact)

PROGRAM_OFFICER_NAME: HODGES, NICHOLAS AARON

PROJECT_TERMS: Adoption;Benign;bioinformatics tool;Biological;Biological Assay;Biological Markers;Biopsy;bisulfite;bisulfite sequencing;Blood;Blood specimen;Breast;Bypass;cancer biomarkers;cancer cell;Cancer Detection;cancer diagnosis;Cancer Patient;cancer type;cell free DNA;Cervix Uteri;Cessation of life;Clinical;clinical care;Cloud Computing;cohort;Collaborations;Colon;Colon Carcinoma;Colorectal Neoplasms;Communication;Computational algorithm;computational platform;computer framework;Computing Methodologies;Copy Number Polymorphism;cost;cost effective;CpG Islands;Data;data sharing;Decentralization;deep neural network;Detection;detection assay;detection test;Development;Diagnostic;Disease;DNA;DNA methylation profiling;Early Diagnosis;Endoscopy;Enrollment;exosome;fighting;General Population;high risk;Human;Image;Immune;improved;Incidence;Individual;industry partner;Learning;liquid biopsy;Literature;Liver;liver cancer patient;Lung;Malignant neoplasm of liver;Malignant neoplasm of lung;Malignant Neoplasms;malignant stomach neoplasm;Methylation;methylation pattern;methylome;microbial;Modality;Modeling;multidisciplinary;multiple omics;Names;Nature;Neural Network Simulation;Nodule;Organ;Patients;Performance;Plasma;prospective;Proteins;Protocols documentation;Publishing;Recommendation;Reproducibility;Resource Sharing;restriction enzyme;RNA;Sampling;screening;Screening for cancer;Screening for Hepatocellular Cancer;screening program;Secure;Signal Transduction;Site;Specificity;Stomach;Technology;Testing;Time;Tissues;Training;trial design;Tube;United States;Validation;whole genome

PROJECT_TITLE: Multi-cancer early detection using cell-free DNA methylome analysis


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Aging;Bioengineering;Biomedical Imaging;Cancer;Prostate Cancer;Urologic Diseases

ORG_CITY: UNIVERSITY PARK

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

PHR: PROJECT NARRATIVE Proposed novel dual-modality transrectal ultrasound and photoacoustic imaging platform, with unique capabilities to map functional, chemical, and molecular information reflecting pathological conditions over the entire human prostate in vivo, will likely help differentiate aggressive from non-aggressive prostate cancer.

PI_NAMEs: KOTHAPALLI, SRI RAJASEKHAR (contact);WANG, XUEDING

PROGRAM_OFFICER_NAME: TATA, DARAYASH B

PROJECT_TERMS: accurate diagnosis;American;anatomic imaging;Animal Model;Biopsy;Biopsy Specimen;Blood Vessels;cancer diagnosis;Cancerous;canine model;Cessation of life;Chemicals;Classification;Clinic;Clinical;clinical diagnosis;Clinical Research;clinical translation;clinically significant;Collaborations;Contrast Media;cost;Detection;Development;Devices;Diagnostic Procedure;Ensure;experience;fabrication;Functional Imaging;Funding;Gleason Grade for Prostate Cancer;Heterogeneity;high resolution imaging;Human;human subject;Hypoxia;Image;Image Enhancement;image guided;Image Guided Biopsy;imaging biomarker;imaging detection;imaging modality;imaging platform;imaging system;Imaging Techniques;improved;in vivo;in vivo imaging system;Indolent;Institution;Intravenous;Light;Magnetic Resonance Imaging;Malignant - descriptor;Malignant neoplasm of prostate;Malignant Neoplasms;Maps;men;Methods;Modality;Molecular;molecular imaging;Needle biopsy procedure;Neoplasm Metastasis;novel;Pathologic;Patient-Focused Outcomes;Patients;Performance;Perfusion;Permeability;personalized medicine;Phase I/II Clinical Trial;photoacoustic imaging;Procedures;Prognosis;Property;Prostate;Prostate Cancer therapy;Prostatic Neoplasms;prototype;Provider;Rectum;Regional Cancer;Research;Resolution;safety assessment;Screening for Prostate Cancer;Statistical Data Interpretation;structural imaging;System;Systems Development;Technology;Time;Tissues;tool;Translating;Translations;Transrectal Ultrasound;tumor;Ultrasonic Transducer;Ultrasonography;ultrasound;uptake;user-friendly;Validation

PROJECT_TITLE: Clinical Translation of dual-modality transrectal ultrasound and photoacoustic imaging for detection of aggressive human prostate cancer

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Bipolar Disorder;Brain Disorders;Clinical Research;Depression;Mental Health;Mental Illness;Neurosciences;Serious Mental Illness

ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: NARRATIVE We are proposing to study a major psychiatric illness, bipolar disorder. The focus of this study is to assess the cerebellum and how metabolism and function of this structure changes with mood using a longitudinal study design.

PI_NAMEs: MAGNOTTA, VINCENT A (contact);WEMMIE, JOHN A

PROGRAM_OFFICER_NAME: LAWHORN, COLLENE

PROJECT_TERMS: Address;anatomic imaging;Anterior;Bipolar Disorder;Bipolar I;blood oxygenation level dependent response;Brain imaging;brain metabolism;Cerebellar vermis structure;Cerebellum;comparison control;Corpus striatum structure;Cross-Sectional Studies;Data;Depressed mood;depressive symptoms;design;Diagnosis;Disease;Emotional;Exhibits;experience;Face;Failure;frontal lobe;Functional disorder;Functional Imaging;Functional Magnetic Resonance Imaging;Future;Impulsivity;Individual;Literature;Longitudinal Studies;Manic;Mental Depression;Mental disorders;Metabolic;metabolic imaging;Metabolism;mood regulation;mood symptom;Moods;Morphology;neural circuit;neuroimaging;novel;novel therapeutics;Participant;Play;Positioning Attribute;psychiatric symptom;Recording of previous events;Research Design;response;Rest;Role;Severities;Sleep disturbances;Structure;Symptoms;Testing;Therapy trial;Translational Research;Work

PROJECT_TITLE: Cerebellar metabolism, neural circuits, and symptoms in bipolar disorder

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Hematology;Precision Medicine;Rare Diseases

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: Cancer cells reprogram signaling, metabolism, and other functions in response to changing environmental conditions. Understanding how malignant cells adapt to environmental stresses requires the ability to analyze cancer cells in real time in physiologic settings. I develop new imaging methods to visualize and quantify functions of cancer cells in tumor environments, providing information and technologies needed to better prevent and treat primary and metastatic cancer.

PI_NAMEs: LUKER, KATHRYN  (contact)

PROGRAM_OFFICER_NAME: JOHNSON, ERIC MICHAEL

PROJECT_TERMS: Animal Model;automated segmentation;Award;Biochemical;Biological Assay;Bioluminescence;bioluminescence imaging;Bone Marrow;Cancer Biology;cancer cell;cancer imaging;Cancer Model;Cells;clinical imaging;co-clinical trial;Code;Complement;Complex;Custom;Data;disease heterogeneity;Disparate;Disseminated Malignant Neoplasm;Engineering;Environment;environmental change;environmental stressor;Event;Exhibits;experience;Firefly Luciferases;fluorescence imaging;fluorescence lifetime imaging;Funding;Goals;Heterogeneity;Image;image processing;imaging modality;in vivo;in vivo bioluminescence imaging;Interdisciplinary Study;invention;Investigational Therapies;Malignant Neoplasms;Metabolism;Methods;Michigan;molecular imaging;molecular scale;multidisciplinary;multiphoton microscopy;Myelofibrosis;Myeloproliferative disease;Neoplasm Metastasis;novel;Oncology;Organism;Pharmacodynamics;Physiological;precision medicine;prevent;Process;Productivity;programs;Qualifying;quantitative imaging;Reporter;Research;Research Personnel;Resources;response;Scientist;Signal Pathway;Signal Transduction;Specialist;Standardization;Stress;Systems Biology;Technology;Time;treatment response;tumor;tumor heterogeneity;tumor progression;Universities;Visualization;Writing

PROJECT_TITLE: Specialist in Multi-Scale Molecular Imaging of Tumor Environments


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Genetics;Health Services;Human Genome;Prevention;Social Determinants of Health

ORG_CITY: Canton

ORG_NAME: HARVARD PILGRIM HEALTH CARE, INC.

PHR: PROJECT NARRATIVE Patients and health care professionals are now able to use genetic information to help prevent, diagnose and select treatments for diseases. Health policies can improve or reduce access to genomic tests; therefore, monitoring the outcomes of policies is an important public health issue. This project will advance the field of genomic medicine by developing and validating analytical methods for efficient, rigorous evaluation of policies that impact access to genomic tests and associated outcomes to inform healthcare and policy decisions.

PI_NAMEs: LU, CHRISTINE  (contact)

PROGRAM_OFFICER_NAME: CHANG, CHRISTINE Q

PROJECT_TERMS: analytical method;analytical tool;Assessment tool;Data Aggregation;Data Analyses;Diagnosis;Disease;distributed data;Environment;Evaluation;Foundations;genetic information;genomic data;Genomic medicine;Genomics;Health Policy;Health Professional;Health system;Healthcare;improved;Individual;innovation;Interruption;Lead;Malignant Neoplasms;Medicare;Methods;Monitor;next generation sequencing;novel;novel strategies;Outcome;Output;patient privacy;Patients;Persons;Policies;Policy Analysis;Policy Maker;population health;Population Heterogeneity;precision medicine;prevent;privacy preservation;Public Health;Quasi-experiment;randomized trial;Recurrence;Refractory;Relapse;Research;Research Design;Resources;Series;Services;Site;Structure;System;Testing;Time;United States;Vision

PROJECT_TITLE: Surveillance for outcomes of genomic medicine policies


ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: CENTER OVERALL: PROGRAM NARRATIVE Breast and cervical cancer kill many millions of women around the world, particularly in Sub-Saharan Africa, despite the fact that deaths and disability related to these cancers can be prevented by early detection and treatment. There are major gaps in the screening for and coordination of care to prevent women’s cancers in countries like Kenya; a profound inequity that threatens the health and well-being of women, their families, and communities. We propose to establish the Enhanced BReast and cErvical cAncer screening in Kenya THROUGH implementation science research and training (BREAKTHROUGH) Center, a partnership between institutions in Kenya, the US, and Canada to: 1/ promote research on how to improve women’s cancer control; 2/ to build the base of future researchers in Kenya that can continue and expand this work; and 3/ to inform policy makers on the best ways to engage women in breast and cervical cancer screenings and link them with appropriate care.

PI_NAMEs: ALI, MOHAMMED KUMAIL;CHUNG, MICHAEL HOONBAE (contact);KINUTHIA, JOHN

PROGRAM_OFFICER_NAME: HANISCH, RACHEL ANN

PROJECT_TERMS: Acceleration;Address;Adoption;advanced disease;Advanced Malignant Neoplasm;Africa;Africa South of the Sahara;Awareness;base;Behavioral;Biometry;Breast Cancer Detection;Breast Cancer Early Detection;Breast Cancer Treatment;Canada;Cancer Burden;Cancer Control;cancer diagnosis;cancer type;care coordination;career;Caring;Cervical Cancer Screening;Cessation of life;Clinic;Clinical;Communities;community engagement;Complex;cost;Country;Data;design;Development;Diagnosis;disability;Disease;Early Diagnosis;Early identification;Early treatment;Economics;Effectiveness;effectiveness testing;effectiveness trial;Epidemiology;Equity;evidence base;experience;Faculty;Family;feasibility testing;Future;Gender;Government;Guidelines;Health;Health Services Accessibility;Health system;HIV;Hospitals;Human Papillomavirus;implementation research;implementation science;implementation strategy;improved;Incidence;Individual;Inequity;Infection;Information Technology;Infrastructure;Institution;International;Intervention;Kenya;Knowledge;knowledge translation;Leadership;Life Style;Link;low and middle-income countries;Malignant Breast Neoplasm;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Maps;Mentors;Mentorship;Methods;mHealth;Morbidity - disease rate;mortality;next generation;Obesity;Oncology;patient oriented;Patients;Pattern;Personal Satisfaction;Policies;Policy Maker;premalignant;prevent;Preventive screening;Primary Care;Process;programs;Provider;Recommendation;Research;Research Personnel;Research Project Grants;Resources;Rest;Scientist;screening;Screening for cancer;Smoking;social;Students;System;Talents;Technology;Testing;Time;Training;Translations;Universities;uptake;user-friendly;Variant;Washington;Woman;Women's Health;Work

PROJECT_TITLE: Enhanced BReast and cErvical cAncer screening in Kenya THROUGH implementation science research and training (The BREAKTHROUGH Center)


NIH_SPENDING_CATS: Breast Cancer;Cancer;Cervical Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;HIV/AIDS;Health Services;Prevention;Primary Health Care;Women's Health Research

PI_NAMEs: CHUNG, MICHAEL HOONBAE (contact)

PROJECT_TERMS: Acceleration;Address;Adoption;Advocate;Africa South of the Sahara;Annual Reports;base;Breast Cancer Detection;Breast Cancer Early Detection;Breast Cancer Treatment;Cancer Control;career;Cervical Cancer Screening;Clinical;Collaborations;Communication;Communities;community engagement;Complex;conflict resolution;Country;Decision Making;design;Development;Discipline;Early Diagnosis;Early treatment;Education;Effectiveness;Electronic Mail;Electronics;Eligibility Determination;Ensure;Equity;Ethics;experience;Faculty;feasibility testing;Feedback;global health;Government;Health;HIV Seropositivity;Hospitals;Human Resources;implementation science;Information Dissemination;Information Technology;Infrastructure;Institution;International;Kenya;Knowledge;knowledge translation;Leadership;Malignant Breast Neoplasm;Malignant neoplasm of cervix uteri;Maps;meetings;Mentors;Methods;mHealth;Morbidity - disease rate;mortality;National Cancer Institute;Newsletter;Occupational activity of managing finances;Oncology;organizational structure;patient oriented;Patients;Personnel Management;Policies;Policy Maker;Primary Care;Professional Organizations;programs;Publications;Reporting;Research;Research Personnel;Research Project Grants;Research Support;Resources;screening;Screening for cancer;Services;social media;Structure;Students;synergism;Teacher Professional Development;Technology;Training;Travel;United States National Institutes of Health;Universities;uptake;user-friendly;Voice;Washington;web site;webinar;Woman;Women's Health;Work;working group

PROJECT_TITLE: Enhanced Cervical Cancer Screening Adoption and Treatment Linkage for HIV positive Women in Kenya (eCASCADE-Kenya)


ORG_CITY: HONOLULU

ORG_NAME: UNIVERSITY OF HAWAII AT MANOA

ORG_STATE: HI

PHR: Project Narrative We propose to establish a SPORE program leveraging Hawai`i's multiethnic population and the University of Hawaii Cancer Center's community-facing translational research infrastructure to conduct minority health research among Asian Americans, Native Hawaiians and Pacific Islanders (AANHPI). We will test innovative approaches to address ethnic/racial disparities in non-alcoholic fatty liver disease (NAFLD) (a liver condition that may lead to chronic liver disease and liver cancer), lung cancer and breast cancer, and develop additional innovative translational research that will benefit Hawai`i, the Pacific region and the rest of the US.

PI_NAMEs: BERENBERG, JEFFREY LEE;LE MARCHAND, LOIC  (contact)

PROGRAM_OFFICER_NAME: HUBBARD, LEAH

PROJECT_TERMS: Address;Adenocarcinoma;Adherence;American;Asian Americans;Behavioral;biobank;Bioinformatics;Biological;Biological Markers;Biometry;Blood specimen;Breast;Breast Cancer Risk Factor;Cancer Burden;Cancer Center;Cancer Center Support Grant;cancer health disparity;Cancer Prognosis;cancer risk;career;Catchment Area;Cells;Center for Translational Science Activities;Central obesity;Characteristics;chronic liver disease;Clinical;Clinical Management;Collaborations;Communities;community based participatory research;community center;Community Clinical Oncology Program;Data Analyses;data management;Data Science;Development;Dietary Practices;Disease;DNA Methylation;Economics;efficacy testing;elastography;Environment;ethnic difference;ethnic disparity;Ethnic Population;Etiology;Evaluation;experience;Fatty acid glycerol esters;follow-up;Freezing;Funding;Future;Goals;Grant;Hawaii;health care quality;health disparity;health equity;Image;improved;Individual;Infrastructure;innovation;Institution;Intervention;Intervention Studies;Leukocytes;lifestyle intervention;Liver;Lung;lung cancer screening;Lung Neoplasms;Magnetic Resonance Imaging;Malignant Breast Neoplasm;Malignant neoplasm of liver;Malignant neoplasm of lung;Malignant Neoplasms;Mammary Neoplasms;Measures;Methylation;Minority;Minority Groups;minority health disparity;Minority Health Research;Molecular;multi-ethnic;multidisciplinary;Mutation;Native Hawaiian;Native Hawaiian or Other Pacific Islander;non-alcoholic fatty liver;non-alcoholic fatty liver disease;Not Hispanic or Latino;Obesity;Outcome;outreach;Pacific Islands;Pathology;Patients;Performance;Phase;phase III trial;Pilot Projects;pilot trial;Population;Population Group;Population Heterogeneity;prediction algorithm;Prevention;Primary carcinoma of the liver cells;prognostic significance;programs;racial difference;racial disparity;radiomics;Randomized;randomized trial;recruit;Research;Research Infrastructure;Research Personnel;Rest;Risk;risk prediction model;screening;screening guidelines;secondary endpoint;Small Cell Carcinoma;Smoker;social culture;Specialized Program of Research Excellence;Squamous Cell;Strategic Planning;Testing;Therapeutic;tool;transcriptomics;Translating;Translational Research;translational study;Translations;tumor;Tumor Biology;tumor microenvironment;underserved minority;Universities;uptake;Visceral;Vulnerable Populations

PROJECT_TITLE: Hawaii Minority Health and Cancer Disparities SPORE


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: LE MARCHAND, LOIC  (contact)

PROJECT_TERMS: Address;Administrative Coordination;Advisory Committees;Advocate;anti-cancer research;Cancer Burden;Cancer Center;Cancer Center Support Grant;cancer health disparity;Cancer Patient;cancer risk;Cancer Survivorship;career;career development;Catchment Area;Center Core Grants;Characteristics;Clinical;clinical center;Clinical Research;Collaborations;Communication;Communities;community advisory board;Community Clinical Oncology Program;community engagement;Community Outreach;Consultations;Core Facility;Data;data sharing;Development;Disparity;Education;Educational workshop;Ensure;ethnic difference;ethnic diversity;Ethnic Origin;Evaluation;expectation;experience;Fostering;Foundations;Future;Goals;Grant;Hawaii;Health Disparities Research;Infrastructure;Institution;Intervention Trial;Joints;Leadership;meetings;minority communities;minority health disparity;Mission;Monitor;multidisciplinary;National Cancer Institute;Office of Administrative Management;oncology program;Outcome;Patient Care;patient population;Patients;Pilot Projects;Play;Productivity;Program Evaluation;programs;Protocols documentation;Race;racial difference;Research;Research Personnel;Research Project Grants;Research Support;Resource Sharing;Resources;Role;Site Visit;skills;Strategic Planning;symposium;timeline;Translational Research;translational research program;underserved minority;Universities

PROJECT_TITLE: Administrative Core


PI_NAMEs: NGUMBAU, NANCY MWONGELI (contact)

PROJECT_TERMS: Acceleration;Address;Adoption;Africa;Africa South of the Sahara;base;Breast Cancer Detection;Breast Cancer Early Detection;Breast Cancer Treatment;Cancer Control;cancer therapy;career;Caring;Case Based Learning;Certification;Cervical Cancer Screening;Clinical;Clinical Skills;community engagement;Competence;Complex;Data;design;Development;Early Diagnosis;Early treatment;Educational workshop;Effectiveness;Ensure;Epidemiology;Equity;experience;Faculty;feasibility testing;Fellowship;Fostering;Future;Government;Grant;hands-on learning;health care disparity;HIV Seropositivity;Hospitals;implementation research;implementation science;Information Technology;Institution;interest;International;Intervention;Journals;Kenya;knowledge translation;Lead;low and middle-income countries;Malignant Breast Neoplasm;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Maps;Medical Students;Mentors;Methods;mHealth;Morbidity - disease rate;mortality;next generation;Nursing Students;Oncology;Paper;patient oriented;Persons;Policies;Positioning Attribute;Primary Care;Productivity;programs;Public Health;Recording of previous events;Research;Research Infrastructure;Research Methodology;Research Personnel;Research Project Grants;Research Training;Resources;science education;Scientist;screening;Screening for cancer;secondary analysis;skills;Students;Teacher Professional Development;Technology;tool;Training;Training Programs;Translating;Universities;uptake;user-friendly;virtual;Washington;Woman;Work;Writing


ADMINISTERING_IC: LM

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Clinical Research;Coronaviruses;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: NARRATIVE We propose research on transforming free-text clinical evidence in the literature into a computable knowledge graph that can better support clinical evidence retrieval, extraction, appraisal and reasoning. This research is expected to support evidence-based clinical research and to enhance the health of the public.  .

PI_NAMEs: CHEN, YONG ;PENG, YIFAN ;WENG, CHUNHUA  (contact)

PROGRAM_OFFICER_NAME: REDDY, GOUTHAM

PROJECT_TERMS: Adoption;augmented intelligence;base;Benchmarking;Clinical;Clinical Research;clinical trial protocol;Clinical Trials;clinically relevant;cognitive task;cohort;Collaborations;computable knowledge;COVID-19 pandemic;COVID-19 patient;Data;data repository;data reuse;Data Set;data sharing;data translator;Databases;deep learning;design;Detection;drug repurposing;Eligibility Determination;Engineering;Ethics;Evaluation;evidence base;Evidence Based Medicine;experience;Expert Systems;explainable artificial intelligence;Face;FAIR principles;fitness;Generations;Goals;Grain;graph knowledge base;Health;Healthcare;Human;human study;improved;Individual;Informatics;Information Retrieval;Intelligence;interoperability;Intervention;Knowledge;knowledge graph;Link;Literature;Measures;Mechanical ventilation;Meta-Analysis;Metadata;Methods;Misinformation;Modeling;mortality risk;Natural Language Processing;Natural Language Processing pipeline;novel;Outcome;Patients;Peer Review;Persons;Policy Maker;Population;Probability;Public Health;Publications;Publishing;PubMed;Qualifying;Randomized, Controlled Trials;Registries;Reporting;Research;Research Design;Research Personnel;Resources;Retrieval;Sample Size;SARS-CoV-2 infection;Science;severe COVID-19;Source;student mentoring;study characteristics;Symbiosis;System;systematic review;task analysis;Technology;Testing;Text;Trust;Update;user centered design;wasting;Work

PROJECT_TITLE: ClinEX - Clinical Evidence Extraction, Representation, and Appraisal

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HSS-X(90)S]


NIH_SPENDING_CATS: Behavioral and Social Science;Biomedical Imaging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Lung Cancer;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Tobacco;Tobacco Smoke and Health

PHR: PROJECT NARRATIVE Native Hawaiian smokers experience one of the highest risk of lung cancer, which is not fully explained by their smoking history. This multilevel translational study aims to identify barriers to lung cancer screening in Native Hawaiians, construct a population-specific risk prediction model to enhance screening guidelines, and molecularly profile lung tumors from Native Hawaiian patients to characterize the biological mechanisms that contribute to their high risk and poor survival. Study findings will help design a culturally informed health education campaign to improve lung cancer screening utilization and provide information towards more tailored precision-based treatment strategies for this high risk underserved population.

PI_NAMEs: PARK, SUNGSHIM LANI (contact)

PROJECT_TERMS: Accounting;Address;Adenocarcinoma;Adenocarcinoma Cell;Adherence;Adult;Advisory Committees;African American population;Age;aged;Archives;Behavior;Belief;Biological;Biological Factors;Biological Markers;Biological Process;burden of illness;Cancer Burden;cancer diagnosis;cancer health disparity;Cancer Intervention and Surveillance Modeling Network;Cancer Patient;cancer risk;Carcinogens;cell type;Characteristics;Chest;Cigarette;cohort;Cohort Studies;Collaborations;Communities;computed tomography screening;Data;Data Set;design;Development;Diagnosis;Disease;Disease Outcome;Disparity;DNA;DNA Methylation;DNA Sequence Analysis;Dose;Early Diagnosis;Eligibility Determination;Epigenetic Process;ethnic difference;ethnic minority;Ethnic Population;European;experience;follow-up;Gene Expression Profile;Gene Expression Profiling;Genes;Genetic;Genetic study;genome-wide;Grant;Guidelines;Hawaii;Hawaiian population;Health;Health behavior;Health education;Healthcare;Heterogeneity;high risk;Histologic;Immune;improved;Individual;informant;Intervention;Interview;Japanese American;Knowledge;Leukocytes;low dose computed tomography;Lung;lung cancer screening;Lung Neoplasms;Malignant neoplasm of lung;Malignant Neoplasms;Medical;Metabolism;Methylation;Michigan;Minority Groups;minority health disparity;Modality;Modeling;Molecular;Molecular Analysis;Molecular Profiling;mortality;multi-ethnic;Mutation;Native Hawaiian;Nicotine;Not Hispanic or Latino;Participant;Patients;Pattern;Perception;Performance;Population;population based;Population Sciences;predictive modeling;Prevention;Preventive service;Prognostic Factor;Provider;racial difference;racial minority;racial population;Recommendation;Risk;risk prediction model;Role;Scanning;screening;screening guidelines;small cell lung carcinoma;Smoke;Smoker;Smoking;Smoking Behavior;smoking cessation;Smoking History;Squamous cell carcinoma;targeted treatment;Tobacco-Associated Carcinogen;Translating;translational study;Treatment Efficacy;treatment strategy;tumor;Tumor Biology;tumor microenvironment;Tumor Tissue;tumor-immune system interactions;Tumorigenicity;underserved minority;Underserved Population;United States Preventative Services Task Force;Universities;uptake

PROJECT_TITLE: Project 2: Mitigating Lung Cancer Disparities in Native Hawaiians: A Population-Based Approach to Evaluate Prevention Barriers and Lung Tumor Biology


NIH_SPENDING_CATS: Behavioral and Social Science;Breast Cancer;Cancer;Cervical Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;HIV/AIDS;Health Services;Infectious Diseases;Networking and Information Technology R&D (NITRD);Prevention;Primary Health Care;Women's Health Research

PI_NAMEs: KOSGEI, ROSE JEPCHUMBA (contact)

PROJECT_TERMS: Acceleration;Acetic Acids;Address;Adherence;Adopted;Adoption;Africa South of the Sahara;Age;Attitude;Awareness;base;behavior change wheel;Breast Cancer Detection;Breast Cancer Early Detection;Breast Cancer Treatment;Cancer Control;Cancer Etiology;care fragmentation;career;Caring;Cervical;Cervical Cancer Screening;Cessation of life;Clinic;Clinical;Clinical Trials;Collaborations;Communities;community engagement;Complex;cost;Data;design;Development;Diagnosis;Early Diagnosis;Early treatment;Effectiveness;effectiveness outcome;effectiveness/implementation study;Ensure;Equity;Faculty;feasibility testing;Female;follow-up;Government;Guidelines;Health;Health Services Accessibility;HIV Seropositivity;Hospitals;Human;Human Papillomavirus;Human Resources;Hybrids;implementation evaluation;implementation outcomes;implementation research;implementation science;implementation strategy;improved;Incidence;Information Technology;Infrastructure;Institution;International;Intervention;intervention cost;Kenya;Knowledge;knowledge translation;Lesion;Letters;Link;low and middle-income countries;Malignant Breast Neoplasm;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Maps;Measures;Mentors;Meta-Analysis;Methods;mHealth;mobile application;Morbidity - disease rate;mortality;Motivation;Oncology;patient oriented;patient screening;Patients;Policies;Policy Making;premalignant;Preparation;Primary Care;primary care clinic;primary care setting;Procedures;programs;Provider;Readiness;Reporting;Research;Research Personnel;Research Project Grants;Research Support;Research Technics;Resources;response;screening;Screening for cancer;screening guidelines;self testing;Site;Structure;Students;System;Technology;Telephone;Testing;Text;Time;Training;treatment services;Triage;Universities;uptake;user-friendly;Visual;Washington;Woman;Women's mortality


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Breast Cancer;Cancer;Neurosciences;Women's Health Research

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Cancer metastases to the leptomeninges (LM) are difficult to treat, create significant morbidity, and portend extremely poor survival. Our proposed work will define how malignant cells hijack developmental neuronal pathfinding mechanisms to enter the central nervous system and study how the innate and adaptive immune systems impact this metastatic pathway. Our studies will provide new mechanistic insight into a poorly understood biologic phenomenon and a therapeutic approach to an area of high unmet clinical need.

PI_NAMEs: SIPKINS, DOROTHY A (contact)

PROGRAM_OFFICER_NAME: GRIL, BRUNILDE M

PROJECT_TERMS: acute lymphoblastic leukemia cell;Acute Lymphocytic Leukemia;Adaptive Immune System;Affect;Affinity;Anatomy;Antibodies;Apoptosis;Area;Basement membrane;bench to bedside;Binding;Biological Phenomena;Blood - brain barrier anatomy;Blood Vessels;blood-brain barrier crossing;bone;Bone Marrow;Breast Cancer Cell;breast cancer metastasis;Breast Cancer Model;Breast Cancer Patient;Breast Cancer Prevention;breast cancer survival;Bypass;Calvaria;cancer cell;Cell Communication;Cell Cycle Progression;cell motility;Cell surface;Cells;Central Nervous System;Cessation of life;Clinical;clinical practice;Collaborations;Complication;Confocal Microscopy;cortical bone;cranium;cytotoxic;Cytotoxic Chemotherapy;Data;Development;Disease;disease model;Disease Progression;effective therapy;Environment;Event;Excision;Exhibits;experience;Exposure to;Extracellular Matrix;glial cell-line derived neurotrophic factor;Hematology;host neoplasm interaction;Human;Hypoxia;imaging approach;Immune;Immune response;Immunoglobulins;in vivo imaging;Inflammation;Innate Immune System;insight;Integrin alpha6;Integrins;Intervention;Intraventricular;Invaded;Laminin;Laminin Receptor;Leptomeningeal Neoplasms;Leptomeninges;leukemia;Macrophage;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant Neoplasms;Mediating;Membrane;Meningeal;Meninges;Metabolism;Metastatic breast cancer;Metastatic malignant neoplasm to brain;Metastatic Neoplasm to the Leptomeninges;metastatic process;Microglia;migration;Molecular;Molecular Target;molecular targeted therapies;Monoclonal Antibodies;monocyte;Morbidity - disease rate;mouse model;Mus;Myelogenous;Myeloid Cells;Neoplasm Metastasis;neoplastic cell;Nervous System;Neurologic Symptoms;Neurons;neurotrophic factor;neutralizing antibody;novel;novel strategies;Nutrient;Operative Surgical Procedures;Pathogenesis;Pathway interactions;Patient-Focused Outcomes;Patients;Phenotype;Play;Pre-Clinical Model;Preclinical Testing;prevent;Process;Proliferating;recruit;Reporting;response;Robin bird;Role;Route;Sampling;scaffold;Seminal;Signal Transduction;Site;Solid;Solid Neoplasm;spine bone structure;Stress;Subarachnoid Space;Surface;targeted treatment;Testing;Therapeutic;therapeutic evaluation;Therapeutic Monoclonal Antibodies;Time;Toxic effect;trafficking;transcriptomics;Transgenic Mice;Translating;treatment response;tumor;tumor behavior;Tumor Cell Invasion;tumor growth;tumor microenvironment;tumorigenic;Vertebral Bone;Work;Xenograft procedure

PROJECT_TITLE: Identifying and exploiting therapeutic vulnerabilities of tumor-host interactions that drive bone-to-meninges breast cancer metastasis

STUDY_SECTION: TEHM

STUDY_SECTION_NAME: Tumor Evolution, Heterogeneity and Metastasis Study Section[TEHM]