NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;Immunization;Infectious Diseases;Lung;Orphan Drug;Prevention;Rare Diseases;Vaccine Related;Valley Fever

PI_NAMEs: YU, JIEH-JUEN  (contact)

PROJECT_TERMS: Acceleration;acute infection;Amphotericin B;Animal Model;anti-fungal agents;Area;Azole resistance;bench-to-bedside translation;Bioinformatics;Biological Assay;Cell Membrane Permeability;Cell Wall;Cells;Central Nervous System;chemotherapy;Clinical;clinically relevant;Coccidioides;Coccidioides immitis;Coccidioides posadasii;Coccidioidomycosis;combat;Complement;Consumption;cost;cost effective;Cytology;cytotoxicity;desert fever;Development;Diameter;Disease;drug candidate;drug development;Drug Screening;Drug Targeting;experience;Flow Cytometry;Fluconazole;Fluconazole resistance;fungus;Gene Expression;Genes;Genetic;Genomics;Goals;Grant;Growth;Health;Hyphae;Image;In Vitro;in vivo;Incidence;Infection;insight;Itraconazole;Lead;Libraries;Life Cycle Stages;Lower respiratory tract structure;Lung;Lung Diseases;Medical;Medicine;Meningitis;Metabolic;meter;Methodology;Methods;Mexico;Microscopy;Modeling;Molecular;Molecular Mechanisms of Action;Morphology;Motivation;mouse model;Mus;Mycoses;New Agents;novel;novel strategies;Nuclear;pandemic response;Pathway interactions;Patients;Persons;Pharmaceutical Preparations;pharmacologic;Pharmacotherapy;Phase;Phenotype;Positioning Attribute;preclinical development;Property;Public Health;Reproduction spores;Research;resistant strain;Resolution;RNA analysis;Rodent Model;screening;side effect;Soil;South America;statistics;Symptoms;System;Testing;The science of Mycology;Therapeutic;therapeutic development;Therapeutic Index;Time;Toxic effect;transcriptome;transcriptome sequencing;transcriptomics;Transmission Electron Microscopy;Treatment Efficacy;United States;vaccine strategy;Vaccines

PROJECT_TITLE: Screening Repurposing Libraries for the Identification of Drugs with Novel anti-Coccidioidal Activity


ADMINISTERING_IC: NS

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: BOSTON

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it determines the efficacy and mechanism of en- hancing 5-HT signaling in preventing seizure-induced mortality in animal models of sudden unexpected death in epilepsy (SUDEP), a serious public health problem. The outcomes are expected to significantly advance the targeted prevention strategies against SUDEP. Thus, the proposed work is relevant to the mission of NINDS that pertains to reducing the burden of neurological disease.

PI_NAMEs: FENG, HUAJUN  (contact)

PROGRAM_OFFICER_NAME: WHITTEMORE, VICKY R

PROJECT_TERMS: 5-hydroxy-tryptophan;Agonist;Amygdaloid structure;Animal Model;Animals;Brain;Cause of Death;cell type;Cessation of life;Citalopram;Clinical;Coupling;Data;DBA/1 Mouse;designer receptors exclusively activated by designer drugs;Development;disease model;Dorsal;dravet syndrome;efficacy evaluation;Electrocardiogram;Electroencephalography;Electrophysiology (science);Epilepsy;Event;Exhibits;Fenfluramine;Fluoxetine;Fostering;Functional disorder;General Population;Goals;HTR2A gene;Human;human disease;human model;Infusion procedures;innovation;Intervention;Knowledge;Literature;Midbrain structure;Mission;Modeling;Monitor;mortality;mouse model;Mus;National Institute of Neurological Disorders and Stroke;Nervous System Disorder;neuronal circuitry;Neurons;neurotransmission;novel;optogenetics;Outcome;Paroxetine;Patients;Pharmaceutical Preparations;pharmacologic;Pharmacology;Plethysmography;pre-clinical;Pre-Clinical Model;prevent;Prevention;Prevention strategy;Preventive;protective effect;Public Health;raphe nuclei;Reducing Agents;Reporting;Research;respiratory;response;reuptake;Risk;Role;Seizures;Serotonin;serotonin 7 receptor;Serotonin Antagonists;serotonin receptor;Signal Transduction;Sudden Death;sudden unexpected death in epilepsy;Technology;Testing;Therapeutic;Treatment Efficacy;Work

PROJECT_TITLE: Prevention of Seizure-Induced Sudden Death by Stimulating Serotonergic Signaling

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Emerging Infectious Diseases;Immunization;Infectious Diseases;Lung;Neurosciences;Orphan Drug;Prevention;Rare Diseases;Vaccine Related;Valley Fever

ORG_CITY: SAN ANTONIO

ORG_NAME: UNIVERSITY OF TEXAS SAN ANTONIO

ORG_STATE: TX

PHR: Coccidioidomycosis (Valley Fever) is a fungal infection that primarily occurs in the US desert Southwest, but disease can also occur in those who have visited this area. We found 37.8% of Coccidioides isolates with decreased in vitro susceptibility to fluconazole, which is commonly used for therapy, but the correlation between in vitro resistance and in vivo response to therapy has not been established. The objective of this study is to utilize our murine models of coccidioidomycosis as well as a retrospective analysis of clinical cases to determine the in vivo significance of decreased susceptibility of Coccidioides to fluconazole, and evaluate the utility of alternative azole therapy.

PI_NAMEs: PATTERSON, THOMAS F. (contact)

PROJECT_TERMS: acute infection;African;Amphotericin B;anti-fungal agents;Area;Arizona;Azole resistance;Azoles;California;candidate identification;Central Nervous System;Central Nervous System Diseases;Central Nervous System Infections;Clinical;clinically relevant;clinically significant;Coccidioides;Coccidioides immitis;Coccidioides posadasii;Coccidioidomycosis;Data;Databases;desert fever;Disease;Dose;Drug Kinetics;Drug Screening;Effectiveness;efficacy evaluation;Ethnic Origin;Evaluation;Filipino;Fluconazole;Fungal Drug Resistance;fungus;Goals;high risk;HIV/AIDS;Immunity;Immunocompromised Host;improved outcome;In Vitro;in vitro activity;in vivo;Incidence;Infection;Inhalation;Integration Host Factors;Link;Lung;Lung infections;Measures;Medical History;Military Personnel;Modeling;mouse model;Mycoses;Nevada;New Mexico;novel;Organ Transplantation;Outcome;Patient-Focused Outcomes;Patients;Pattern;Pharmaceutical Preparations;Pharmacodynamics;Predisposition;Pregnancy;Progressive Disease;Recommendation;Research;Resistance;Respiratory Signs and Symptoms;response;Risk;Testing;Texas;Therapeutic;therapeutic development;Time;Treatment Efficacy;treatment response;Utah;vaccine strategy;Vaccines;Virulent;Visit;Work

PROJECT_TITLE: Relationship between in vitro antifungal resistance and in vivo response in coccidioidomycosis


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Digestive Diseases;Genetics;Human Genome;Immunotherapy;Orphan Drug;Pancreatic Cancer;Precision Medicine;Prostate Cancer;Rare Diseases;Stomach Cancer;Urologic Diseases

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

ORG_STATE: NY

PHR: The cataloging of mutations in human cancers has produced new insights into oncology, but functional studies in relevant model systems are needed to interpret and exploit this information. Herein we propose to develop a rapid and inexpensive platform based on electroporation of genetic elements into specific tissues of adult mice to study cancer drivers and the dependencies they create in an immunocompetent and physiological context. Our approach will contribute to our understanding of cancer mechanisms and provide a suite of genetically- engineered mouse models that will facilitate evaluation of targeted therapies and immune oncology agents.

PI_NAMEs: LOWE, SCOTT W. (contact)

PROGRAM_OFFICER_NAME: WATSON, JOANNA M

PROJECT_TERMS: Address;Adoption;Adult;anti-cancer research;Benchmarking;Biological Markers;Biological Models;Cancer Biology;cancer cell;cancer diagnosis;cancer genome;cancer initiation;Cancer Model;Cataloging;Catalogs;Cell Line;Cell Signaling Process;cell type;Cells;checkpoint therapy;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;Collection;Combination immunotherapy;Combined Modality Therapy;Communities;Credentialing;Data;Dependence;Development;Disease Progression;DNA sequencing;efficacy evaluation;efficacy testing;Electroporation;Engineering;Epigenetic Process;Epithelium;Evaluation;FGFR1 gene;flexibility;Flow Cytometry;Genes;Genetic;Genetic Annotation;Genetic Diseases;genetic element;Genetic Variation;Genetically Engineered Mouse;Genome;Genome engineering;genome sequencing;Genomics;Genotype;Goals;host neoplasm interaction;Human;Human Biology;human cancer mouse model;human disease;human model;Immune;immune cell infiltrate;Immunocompetent;Immunooncology;immunoregulation;in vivo;in vivo Model;insight;Laboratories;Lesion;Maintenance;Malignant neoplasm of pancreas;Malignant neoplasm of prostate;Malignant Neoplasms;malignant stomach neoplasm;Mediating;Methods;Minor;Modeling;Molecular;Molecular Analysis;mouse model;Mus;Mutation;Myeloid-derived suppressor cells;new therapeutic target;next generation;novel;novel therapeutic intervention;novel therapeutics;Oncogenes;Oncology;Organ;patient derived xenograft model;Patient-Focused Outcomes;Patients;Phenotype;Physiological;Physiology;portability;pre-clinical;Pre-Clinical Model;precision oncology;preclinical study;Property;prostate cancer model;Reagent;Regulatory T-Lymphocyte;response;Role;Series;Somatic Mutation;standard of care;targeted treatment;Testing;Therapeutic;therapeutic target;therapy development;Tissues;tool;Toxic effect;transcriptome sequencing;Translational Research;translational study;Treatment Protocols;treatment response;tumor;tumor behavior;tumor microenvironment;tumor progression;Tumor Suppressor Genes;tumorigenesis;wasting;whole genome

PROJECT_TITLE: Rapid and flexible precision oncology mouse models of epithelial malignancies epithelial malignancies

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-J(55)R]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Services;Prevention;Social Determinants of Health;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: COLUMBIA

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

ORG_STATE: SC

PHR: PROJECT NARRATIVE: The US Food and Drug Administration (FDA) can select content for health warning labels and package inserts (i.e., small printed leaflets inside cigarette packs) if they can help smokers quit. This proposed study will test whether inserts with messages about the benefits of cessation and tips for quitting help smokers quit. To do this, we will take advantage of the unique opportunity to evaluate the innovative insert policy in Canada and will conduct the first experimental study of cigarette package inserts among smokers in the United States.

PI_NAMEs: THRASHER, JAMES  (contact)

PROGRAM_OFFICER_NAME: KAUFMAN, ANNETTE R

PROJECT_TERMS: Adult;Area;Attention;Behavior;behavior change;behavioral outcome;behavioral response;Canada;Cessation of life;Cigarette;cohort;Communication;communication theory;Complement;Complement component C1;consumer behavior;cost;Country;Data;Data Collection;Decision Making;Disease;Ecological momentary assessment;Effectiveness;Emotional;Empirical Research;Evaluation;experience;experimental study;Exposure to;Goals;health communication;Health Policy;health warning;implementation study;improved;innovation;International;Label;Manufacturer;Mediator;Methods;negative affect;Outcome;outcome prediction;Package Insert;Participant;Pathway interactions;Persons;Play;Policies;Policy Developments;Policy Making;post implementation;Printing;Product Labeling;prolonged abstinence;Prospective cohort;Protocols documentation;psychologic;psychological outcomes;Public Health;public health intervention;public policy on tobacco;randomized, clinical trials;Randomized, Controlled Trials;recruit;Regulation;Research;response;Role;Rotation;Sampling;Self Efficacy;Smoker;Smoking;smoking abstinence;smoking cessation;Socioeconomic Status;Surveys;synergism;Testing;Text;theories;Time;tobacco products;United States;United States Food and Drug Administration;warning label;Work

PROJECT_TITLE: Evaluation of cigarette package inserts for enhanced communication with smokers


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Emerging Infectious Diseases;Genetics;Immunization;Immunotherapy;Infectious Diseases;Orphan Drug;Prevention;Rare Diseases;Vaccine Related;Valley Fever

PHR: Project Narrative Our central hypothesis is that the newly created GCP-rCpa1-mRNA and vector-based (Fn-iglD-rCpa1) vaccines that express coccidioidal Cpa1 antigen can stimulate a robust and durable Th1/Th17 protective immunity against both species of Coccidioides as well as they may be used as immunotherapy agents for coccidioidomycosis. The efficacy, protective correlatives an immune mechanisms will be determined for the newly created vaccines. The GCP-rCpa1-mRNA and vector-based vaccines can be rapidly scaled up for production of high quantity and quality vaccines that can be ready for preclinical and clinical trials.

PI_NAMEs: HUNG, CHIUNG-YU  (contact)

PROJECT_TERMS: Active Immunization;Active Immunotherapy;adaptive immunity;Adjuvant;anti-fungal agents;Antigen Presentation;Antigen-Presenting Cells;Antigens;Area;Attenuated;attenuation;Azoles;Benchmarking;beta-Glucans;Blood Cells;Blood specimen;Cells;chemotherapy;Chitin;Chronic;clinic ready;Clinical;Clinical assessments;Clinical Trials;Coccidioides;Coccidioidomycosis;Combined Modality Therapy;cytokine;delivery vehicle;design;DNA;Fever;Fluconazole resistance;Formulation;Francisella;Francisella tularensis;Gene Expression;Gene Expression Profiling;Genes;Genetic Transcription;Glucans;HLA-DR4 Antigen;Human;human disease;Immune;Immune system;Immunity;immunogenic;Immunologics;Immunotherapeutic agent;Immunotherapy;improved;In Vitro;in vivo;Individual;Laboratories;Lung;Lung infections;Macaca;Macrophage;manufacturing scale-up;Mediating;Messenger RNA;Methods;Military Personnel;Modeling;mouse model;Mus;mutant;novel;novel vaccines;Oryctolagus cuniculus;particle;Patients;Personal Satisfaction;Persons;Pharmaceutical Preparations;polypeptide;Population;Preclinical Testing;preclinical trial;Process;Production;protective efficacy;Proteins;Protocols documentation;Rattus;Recombinants;Reporting;Research;research clinical testing;resistant strain;response;RNA vaccine;Rodent;Safety;scale up;Speed;Subunit Vaccines;System;T-Lymphocyte;T-Lymphocyte Epitopes;therapeutic development;therapy outcome;Transgenic Mice;Travel;Treatment Efficacy;Tularemia;United States;Vaccination;Vaccine Antigen;vaccine candidate;vaccine development;vaccine formulation;vaccine immunogenicity;Vaccines;vector;vector vaccine;vector-based vaccine;Virulent;Yeasts

PROJECT_TITLE: Project #3:Active Vaccination and Immunotherapy Against Coccidioidomycosis


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Brain Disorders;Genetics;Human Genome;Huntington's Disease;Muscular Dystrophy;Myotonic Dystrophy;Neurodegenerative;Neurosciences;Prevention;Rare Diseases

ORG_CITY: Boston

ORG_DEPT: BIOLOGY

ORG_NAME: TUFTS UNIVERSITY MEDFORD

PHR: PROJECT NARRATIVE All cells encounter replication barriers upon genome duplication, and must overcome those barriers to restart replication. Failure to restart the replication process leads to chromosome breaks and mutations, as occurs in cancer cells under replication stress. Successful completion of the experiments proposed will significantly enhance our understanding of replication and the genetic pathways that normally prevent disease-causing mutations and cancer initiation.

PI_NAMEs: FREUDENREICH, CATHERINE H (contact)

PROGRAM_OFFICER_NAME: REDDY, MICHAEL K

PROJECT_TERMS: Back;base;Biochemical;CAG repeat;cancer cell;cancer initiation;Cell Nucleus;Cell Physiology;Cells;Chromosomal Breaks;Chromosome Breakage;Chromosome Deletion;chromosome mutation;Data;Disease;disease-causing mutation;DNA;DNA replication fork;DNA Structure;Elements;experimental study;Failure;G2 Phase;Genetic;Genome;Genome Stability;Genomic Instability;Goals;Human;Human Genome;Huntington Disease;Laboratories;Link;Location;Microsatellite Repeats;Microscopy;Modification;Mutation;Myotonic Dystrophy;novel strategies;Nuclear;Nuclear Pore;Nuclear Pore Complex;Pathway interactions;Post-Translational Protein Processing;prevent;Proteins;Proteome;Recovery;repaired;replication stress;Replication-Associated Process;Role;S phase;Saccharomyces cerevisiae;Saccharomycetales;Short Tandem Repeat;Spinocerebellar Ataxias;Structure;Sumoylation Pathway;System;Techniques;yeast genetics;yeast genome;Yeasts

PROJECT_TITLE: Replication through DNA Structures and Consequences for Genome Stability

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Endometriosis;Genetics;Human Genome;Lung;Lung Cancer;Ovarian Cancer;Precision Medicine;Prevention;Rare Diseases;Women's Health Research

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE Ovarian cancer is the most lethal gynecologic malignancy, with few known modifiable risk factors, and no effective screening methods or unique symptoms for detection in early stages. Better therapeutic options are needed for the less studied histological types of ovarian cancer that show variable or poor response to platinum-taxane based therapy. Our approach uses integrated analysis of multiple layers of information, including relationships between risk factors and genomic and prognostic associations, to provide powerful biological and mechanistic insight into ovarian cancer biology with potential to point to novel targeted therapeutic options.

PI_NAMEs: GOODE, ELLEN L. (contact)

PROGRAM_OFFICER_NAME: GALLICCHIO, LISA M

PROJECT_TERMS: Age;Algorithms;Biological;Biological Process;Body mass index;Cancer Biology;Cellular biology;chemotherapy;Clear Cell;Clinical;Collaborations;Communities;Complement;Data;Detection;Development;Diabetes Mellitus;diagnostic criteria;endometriosis;Epidemiology;epidemiology study;Etiology;Fatal Outcome;Foundations;Future;Gene Expression;Genetic Predisposition to Disease;genomic data;genomic profiles;Genomics;hazard;histological studies;Histology;Hyperlipidemia;Incidence;innovation;insight;Investigation;Knowledge;Malignant Female Reproductive System Neoplasm;Malignant neoplasm of ovary;Malignant Neoplasms;Methods;Methylation;Modeling;modifiable risk;Molecular;Molecular Profiling;molecular subtypes;Mutation;neoplastic cell;new therapeutic target;novel;novel therapeutic intervention;Outcome;Ovarian Clear Cell Tumor;Pathogenesis;Pathologic;Pathway Analysis;patient subsets;Patients;Pattern;personalized approach;Platinum;Precision therapeutics;Prevention strategy;prognostic;Progression-Free Survivals;protein expression;Recording of previous events;Reproducibility;Research;Research Personnel;Resistance;Resources;response;Risk;Risk Factors;Sample Size;Sampling;screening;secondary analysis;Serous;Smoking;Somatic Mutation;Specificity;Structure;Subgroup;Supporting Cell;Survival Rate;Susceptibility Gene;Symptoms;targeted treatment;taxane;Testing;Therapeutic;Training;tumor;Tumor Subtype;Update;Woman

PROJECT_TITLE: Relating Molecular Subgroups of Endometriosis-Associated Ovarian Cancers to Survival and Risk

STUDY_SECTION: CHSA

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology A Study Section[CHSA]


ADMINISTERING_IC: DK

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Clinical Research;Digestive Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: Project Narrative Human Wnt2b deficiency is marked by neonatal onset diarrhea and intestinal inflammation and features diminished Lgr5+ intestinal stem cells (ISC), which function to maintain the intestinal epithelium. Given that Wnt2b was not previously thought to be required for intestinal health, this project seeks to understand how loss of Wnt2b leads to loss of Lgr5+ISC and to development of intestinal disease. The results of this investigation may have wide implications, as ISC health is linked to a number of other, more common, intestinal disorders such as inflammatory bowel disease and gastrointestinal cancers.

PI_NAMEs: OCONNELL, AMY E (contact)

PROGRAM_OFFICER_NAME: SASLOWSKY, DAVID E

PROJECT_TERMS: Affect;Architecture;biological adaptation to stress;Biological Models;Biopsy;Biopsy Specimen;Boston;career;career development;Cell Count;Cell Maintenance;Cells;Chronic;Clinical;Coculture Techniques;Compensation;Death Rate;Development;Development Plans;Diarrhea;Digestive System Disorders;Disease;Doctor of Philosophy;Duodenum;Epithelial Cells;Epithelium;fetal;FOXL1 gene;Gene Expression Profile;Genetic Transcription;genome editing;Goals;gut inflammation;Health;HIF1A gene;Histologic;Human;Hypoxia;Hypoxia Inducible Factor;Immunofluorescence Immunologic;Immunologist;Immunology;In Situ Hybridization;Individual;induced pluripotent stem cell;Infection;Inflammatory;Inflammatory Bowel Diseases;Instruction;integration site;interest;Intestinal Diseases;intestinal epithelium;intestinal homeostasis;Intestines;Investigation;knock-down;Knockout Mice;Knowledge;LGR5 gene;Ligands;Link;Maintenance;Malignant neoplasm of gastrointestinal tract;Malignant Neoplasms;Measures;Mentors;Mesenchymal;Mesenchyme;Messenger RNA;Modeling;Morbidity - disease rate;Morphology;mortality;mRNA sequencing;Mucous Membrane;Mus;Neonatal;neonatal mice;neonatal period;neonate;OLFM4 gene;Organogenesis;Organoids;Paper;Pathway interactions;Pediatric Hospitals;Persons;Physicians;Platelet-Derived Growth Factor alpha Receptor;Population;Process;Production;Radiation Injuries;Rare Diseases;Regulation;Reporting;Research;Research Personnel;response;Role;Scientist;Signal Transduction;small hairpin RNA;Small Intestines;small molecule;Source;stem cell biology;stem cell homeostasis;stem cells;Stromal Cells;System;Techniques;Training;transcriptomics;Translational Research;WNT2B gene;Work

PROJECT_TITLE: The Role of Wnt2b in Intestinal Health

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


ED_INST_TYPE: SCHOOLS OF MEDICINE

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Emerging Infectious Diseases;Immunization;Infectious Diseases;Prevention;Vaccine Related

ORG_CITY: ATLANTA

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Infectious diseases such as influenza, pneumonia, infectious diarrhea, sexually transmitted infections and emerging infectious diseases (e.g. Ebola, Zika) remain a major threat to public health. This new, influential leadership group (IDCRCLG) represents infectious diseases expertise at eight leading academic institutions and beyond to focus on clinical research to address these threats. The IDCRCLG will, through innovative approaches, support the planning, implementation and dissemination of clinical research to address the priorities of NIH/NIAID in evaluating vaccines, biologics, therapeutics, diagnostics and devices for the treatment and prevention of these infectious diseases; and to respond rapidly during an epidemic threat.

PI_NAMEs: STEPHENS, DAVID S (contact)

PROGRAM_OFFICER_NAME: LEE, MARINA

PROJECT_TERMS: Address;Adopted;Ancillary Study;Area;Biological Assay;Biological Products;career development;Clinical;clinical application;Clinical Research;Clinical Trials;Collaborations;Common Data Element;Communicable Diseases;Communication;Communities;Complex;Containment;Data;data management;Data Science;Dedications;Devices;Diagnosis;Diagnostic;Diarrhea;disease transmission;Dissemination and Implementation;drug discovery;Drug Kinetics;Ebola;Elements;Emerging Communicable Diseases;Emerging infection;Ensure;enteric infection;Environment;epidemic potential;Ethics;Evaluation;experience;first-in-human;flexibility;Foundations;Funding;Future;Genomics;global health;Human;Immunologics;Immunology;improved;industry partner;Infectious disease threat;infectious disease treatment;Influentials;Influenza;Infrastructure;innovation;Institution;International;Intervention Trial;Investigational New Drug Application;Laboratories;laboratory experiment;Laboratory Research;Leadership;life span;Link;lipidomics;Malaria;Mentors;metabolomics;Methods;microbial;microbiome;Monitor;multi-site trial;National Institute of Allergy and Infectious Disease;next generation;novel;novel strategies;operation;organizational structure;Outcome;Participant;Pathogenesis;Patients;Performance;performance site;Phase;Pneumonia;Policies;Population;Population Heterogeneity;Prevention;Private Sector;Procedures;product development;programs;Proteomics;protocol development;Protocols documentation;Public Health;public health emergency;public-private partnership;Publications;Qualifying;reconstitution;Research;Research Activity;Research Design;Research Priority;research study;Resources;Respiratory Tract Infections;Risk Assessment;risk mitigation;Science;Scientist;Services;Sexually Transmitted Diseases;Site;Specimen;support network;Systems Biology;Techniques;Therapeutic;Training;transcriptomics;Translating;trial design;Tropical Disease;Underserved Population;United States;United States National Institutes of Health;Universities;vaccine evaluation;vaccine trial;Vaccines;Vulnerable Populations;working group;ZIKA

PROJECT_TITLE: Leadership Group for the Infectious Diseases Clinical Research Consortium (IDCRCLG)


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Aging;Atherosclerosis;Biotechnology;Cardiovascular;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Human Genome;Prevention

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: PUBLIC HEALTH RELEVANCE Coronary artery disease is the leading cause of death in the United States. It manifests itself in the arteries and can lead to myocardial infarction. Understanding the biological networks that underlie the complex interactions in coronary artery disease is required for disease prevention, diagnosis, and treatment.

PI_NAMEs: CIVELEK, METE  (contact)

PROGRAM_OFFICER_NAME: CATANIA, SELEN MURATOGLU

PROJECT_TERMS: Affect;African ancestry;Allelic Imbalance;Anti-Hypertensive Agents;Aorta;Arterial Fatty Streak;Arteries;ARVCF gene;ascending aorta;Asian ancestry;Atherosclerosis;Bayesian Network;Biological;Biological Assay;Blood Vessels;calcification;causal variant;Cause of Death;Cell Culture Techniques;Cell Physiology;Cell Separation;cell type;Characteristics;Cholesterol;Chromatin;chromatin remodeling;clinical care;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;Computational Biology;Coronary;Coronary Arteriosclerosis;Coronary artery;cytokine;Data;Diagnosis;Disease;Disease susceptibility;disorder prevention;disorder risk;Donor person;drug discovery;Early Diagnosis;Enhancers;Environmental Risk Factor;European ancestry;experimental study;gain of function;Gene Expression;Gene Expression Regulation;gene function;gene interaction;gene network;gene regulatory network;Genes;Genetic;genetic approach;Genetic study;Genetic Transcription;genetic variant;Genetic Variation;Genome;genome wide association study;genomic locus;Genotype;Goals;Heart Transplantation;Human;Human Resources;Immunohistochemistry;In Vitro;Individual;Inflammatory;Latinx;Lentivirus;Linkage Disequilibrium;Lipids;loss of function;Maps;Measures;migration;Modeling;Molecular;multi-ethnic;Myocardial Infarction;particle;Pathway interactions;Pharmaceutical Preparations;Phenotype;Play;Process;Proliferating;Protein Analysis;Proteins;public health relevance;Quantitative Trait Loci;Regulation;Regulatory Element;Reporter;Research;Resources;response;Risk;Risk Factors;RNA;Role;Series;Serum;Single Nucleotide Polymorphism;Smooth Muscle Myocytes;Specimen;Stimulus;Sudden Death;System;Testing;Time;Transcript;transcription factor;transcriptome sequencing;transdifferentiation;Translating;Transposase;United States;Untranslated RNA;Update;Variant;Vascular Smooth Muscle;Western World

PROJECT_TITLE: Systems Genetics of Vascular Smooth Muscle Phenotypes

STUDY_SECTION: BBHV

STUDY_SECTION_NAME: Basic Biology of Blood, Heart and Vasculature Study Section [BBHV]


ORG_CITY: LOS ANGELES

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: Project narrative: Heart failure is a major cause of death in the US contributing significantly to the burden of the healthcare system every year. During failure, the heart undergoes gene expression changes that render structural and functional defects and ultimately result in death. This program utilizes mouse as a model to discern the transcriptional regulatory mechanisms important for sustaining cardiac structure and function in normal and stressed hearts.

PI_NAMEs: CHEN, JAU-NIAN  (contact)

PROGRAM_OFFICER_NAME: TJURMINA, OLGA A

PROJECT_TERMS: Ablation;Address;Adult;Attention;Binding;Biogenesis;biological adaptation to stress;Biological Models;Biology;Cardiac;Cardiac health;Cardiac Myoblasts;Cardiac Myocytes;cardiac repair;cardiogenesis;Cause of Death;Cell Physiology;Cellular Structures;Cessation of life;ChIP-seq;Complex;Data;Defect;Development;Dilated Cardiomyopathy;DNA Polymerase II;Embryo;Epigenetic Process;epigenetic regulation;epigenome;Excision;Failure;Gene Expression;Gene Expression Regulation;Gene Transfer;Genes;Genetic;Genetic Transcription;Goals;healthcare burden;Healthcare Systems;Heart;heart damage;Heart failure;heart function;Heart Injuries;heart preservation;Heterogeneity;histone modification;Homeostasis;Injury;injury and repair;insight;Investigation;knock-down;Knock-out;Knowledge;Lead;loss of function;Maintenance;Mediating;Messenger RNA;metabolomics;model organism;Modeling;Molecular;molecular array;Morphology;mouse genetics;Mus;Muscle Cells;Myocardial;Myocardial dysfunction;Myocardial Infarction;Natural regeneration;neonatal injury;novel;overexpression;Pathogenesis;Pathologic;Phenotype;Physiological;Physiology;Play;preservation;prevent;progenitor;programs;Proliferating;promoter;protective effect;Regulation;Repression;RNA;RNA Polymerase II;Role;Sarcomeres;Stress;Structure;therapeutic target;Time;Transcription Elongation;transcription factor;Transcription Initiation;Transcriptional Regulation;transcriptome;transcriptome sequencing;transcriptomics;Ventricular;Zebrafish

PROJECT_TITLE: Impacts of transcription elongation on cardiac gene regulation during homeostasis and regeneration

STUDY_SECTION: CCHF

STUDY_SECTION_NAME: Cardiac Contractility, Hypertrophy, and Failure Study Section[CCHF]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative We will develop a novel research platform to noninvasively image and control heart function in fly models. Tachycardia, bradycardia and cardiac arrest will be stimulated using light and the cardioprotective effects of preconditioning will be explored. The new knowledge and novel insights gleaned from these studies will advance our understanding of conserved molecular mechanisms on hypoxia-induced changes in the heart and ischemic preconditioning.

PI_NAMEs: ZHOU, CHAO  (contact)

PROGRAM_OFFICER_NAME: FLEG, JEROME L

PROJECT_TERMS: Abdomen;Aging;Anatomy;Animal Model;Autophagocytosis;Behavioral;Biological Assay;Biological Models;Bradycardia;Cardiac;Cardiac Function Study;cardioprotection;Collaborations;Color;Consumption;deep learning;design;Development;Dorsal;Drosophila genus;Drosophila melanogaster;Drug Targeting;Electric Stimulation;experimental study;fly;Future;General Hospitals;Genes;Genetic;Genetic Models;Glean;Heart;Heart Arrest;Heart Diseases;heart function;heart imaging;Heart Injuries;Heart Rate;heart rhythm;Human;human disease;Hypoxia;Image;image processing;Imaging technology;in vivo;insight;instrument;invention;Ion Channel;Ischemia;Ischemic Preconditioning;Knowledge;Light;Lysosomes;Massachusetts;Modeling;Molecular;Morphologic artifacts;Myocardial Ischemia;Names;neural;non-invasive imaging;novel;Opsin;Optical Coherence Tomography;optical imaging;Optics;optogenetics;Oranges;Organism;Pathway interactions;Physiology;preconditioning;Prevention;Productivity;programs;Proteins;Publishing;real-time images;Recovery;Reperfusion Therapy;Research;Research Design;response;Role;Science;segmentation algorithm;Series;Side;Stress;Surface;System;Tachycardia;Technology;Testing;Time;Tissues;tool;Transgenic Organisms;Tube;Universities;Washington

PROJECT_TITLE: High-throughput integrated live imaging and optogenetic pacing platform to assess hypoxia responsiveness in the fly heart

STUDY_SECTION: ITD

STUDY_SECTION_NAME: Imaging Technology Development Study Section[ITD]


NIH_SPENDING_CATS: Genetics

ORG_NAME: NEW YORK UNIVERSITY

PHR: PROJECT NARRATIVE The centromere is a specific chromatin domain responsible for equal segregation of duplicated chromosomes into daughter cells during cell division. Centromere dysfunction results in an abnormal number of chromosomes in dividing cells, a phenomenon observed in more than 90% of all cancers. The proposed study will advance our understanding of how perturbations in centromere regulation lead to cancer and other diseases, and potentially allow us to design new strategies for the diagnosis and treatment of such diseases.

PI_NAMEs: LI, FEI  (contact)

PROGRAM_OFFICER_NAME: VATAKIS, DIMITRIOS NIKOLAOS

PROJECT_TERMS: Address;Affect;Aneuploidy;Biochemistry;Cell Cycle;Cell division;Cells;Cellular Structures;Centromere;centromere protein A;Chromatin;chromosome number abnormality;Chromosome Segregation;Chromosomes;Cytology;Daughter;daughter cell;design;Development;Diagnosis;Disease;DNA biosynthesis;Down's Syndrome;Ensure;Epigenetic Process;epigenetic regulation;Eukaryota;Eukaryotic Cell;Fission Yeast;Foundations;Functional disorder;Gene Silencing;Genetic;Genome;Genomics;Goals;Heterochromatin;Histone H3;Human;human disease;insight;interdisciplinary approach;Kinetochores;Knowledge;Lead;Link;Malignant Neoplasms;Meiosis;Mitosis;model organism;Molecular;Normal Cell;prevent;Process;Regulation;Role;segregation;Specific qualifier value;structural biology;Ubiquitin-mediated Proteolysis Pathway;Variant

PROJECT_TITLE: Molecular Basis of Centromere Specification and Inheritance

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-E(55)R]


NIH_SPENDING_CATS: Biomedical Imaging;Clinical Research;Genetics;Muscular Dystrophy;Myotonic Dystrophy;Neurosciences;Rare Diseases

PHR: PROJECT NARRATIVE Myotonic dystrophy (DM) is the most frequent muscular dystrophy in adults with a prevalence of 1 in 8,000 people, it affects several organs such as skeletal muscle, heart, and brain, it is inherited in an autosomal dominant fashion, and no cure exists to date. Promising therapies are in current development to target the expanded RNA-mediated toxicity associated with this disease; however, reliable biomarkers to monitor disease activity and response to upcoming treatments are lacking. For this purpose, this research proposal aims at identifying non-invasive, painless, and quantitative biomarkers of DM muscle disease by using, in parallel but independently, muscle ultrasound and MRI, and electrical impedance myography at two-year interval in these patients.

PI_NAMEs: GONZALEZ-PEREZ, PALOMA  (contact)

PROGRAM_OFFICER_NAME: NUCKOLLS, GLEN H

PROJECT_TERMS: Address;Adult;Advisory Committees;Affect;Age;Agreement;Animal Disease Models;Architecture;Area;arm;Atmosphere;Atrophic;autosome;Bilateral;Biological Markers;Biometry;Biopsy;Blinded;Brain;candidate marker;career;career development;catalyst;Clinical;Clinical Research;Clinical Trials;Collaborations;Computing Methodologies;Data;data acquisition;design;Development;Diagnosis;disability;Disease;Disease Progression;Distal;DNA;efficacy evaluation;electric impedance;Environment;Fatty acid glycerol esters;Fingers;Flexor;Forearm;Foundations;Frequencies;Future;General Hospitals;Genes;Goals;grasp;Heart;Image;In Vitro;Infiltration;Inherited;lectures;Leg;Limb structure;Longitudinal cohort;Magnetic Resonance Imaging;Massachusetts;Measurement;Measures;Mediating;Medical Research;medical schools;meetings;Mentors;molecular marker;Monitor;mouse model;Muscle;Muscle Fibers;Muscle relaxation phase;muscle strength;Muscle Weakness;Muscular Atrophy;Muscular Dystrophies;musculoskeletal imaging;musculoskeletal ultrasound;mutant;Myography;Myopathy;Myotonia;Myotonic Dystrophy;neuromuscular;Neuromuscular conditions;Neuromuscular Diseases;new technology;Nucleotides;Ocimum basilicum;Organ;Pacemakers;Painless;patient oriented research;patient response;Patients;Pattern;Persons;Phase;Physiologic pulse;Pilot Projects;Population;portability;Positioning Attribute;Prevalence;Probability;Publications;Readiness;Relaxation;Reporting;Research;Research Personnel;Research Proposals;Resistance;response;responsible research conduct;RNA;Role;Sampling Biases;Scientist;Severity of illness;sex;Skeletal Muscle;Specialist;Sum;System;Testing;Thick;Thigh structure;Time;time interval;tool;Toxic effect;Training;Transcript;transcriptomics;Translational Research;Ultrasonography;ultrasound;Validation;Visit;Walking

PROJECT_TITLE: Clinical and Non-Invasive Biomarkers of Myotonic Dystrophy


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Genetics;Pediatric;Rare Diseases

ORG_CITY: ANN ARBOR

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Midfacial hypoplasia is a devastating condition caused by structural defects of the cranial base, resulting in difficulties breathing, chewing and often necessitating surgical correction. While it is understood that the cranial base promotes craniofacial growth, and that cartilage cells (chondrocytes) are required for its development, the molecular mechanisms that regulate these processes are unknown. The objective of this proposal is to define mechanisms by which cranial base chondrocytes function to promote growth of the midface in order to identify future therapeutic targets for the treatment of cranial base malformations.

PI_NAMEs: HALLETT, SHAWN ALEXANDER (contact)

PROGRAM_OFFICER_NAME: FUQUA, CHANTEL FAYSAN

PROJECT_TERMS: Acceleration;Achondroplasia;Address;Affect;Architecture;Back;Biological;Biology;bone;Breathing;Cartilage;cartilage cell;Cells;Central Nervous System;Chondrocytes;Cleidocranial Dysplasia;Clinical;Color;comparative;Complex;Coupled;craniofacial;craniofacial development;Critical Thinking;Data;Dentists;Development;Dissociation;Epiphysial cartilage;FGFR3 gene;Fibroblast Growth Factor;Fluorescence-Activated Cell Sorting;Foundations;Future;gain of function;gain of function mutation;Genes;Goals;Growth;Growth and Development function;Heterogeneity;Histologic;Human;Hypertrophy;In Situ Hybridization;in vivo;innovation;insight;intercalation;Investigation;Knowledge;long bone;malformation;MAP Kinase Gene;Mastication;Mediating;Microdissection;midfacial hypoplasia;mineralization;Molecular;Morphology;mouse model;Mus;mutant;Mutate;Nose;novel;Operative Surgical Procedures;Oral;orthognathic;osteoblast differentiation;Osteoblasts;Osteogenesis;Pathway interactions;Patients;Pattern;Phenotype;Physiologic Ossification;Population;postnatal;postnatal development;premature;premature ossification;Process;programs;Proliferating;Reconstructive Surgical Procedures;Regulation;Research;Respiratory System;Rest;Role;Scientist;Signal Transduction;single-cell RNA sequencing;skeletal;skeletal maturation;skeletal tissue;skills;skull base;Stains;Structural defect;Techniques;Testing;therapeutic target;Therapeutically Targetable;Tissues;tool;transcription factor;transcriptomics

PROJECT_TITLE: Unraveling the Cellular Dynamics of the Cranial Base Synchondroses Throughout Postnatal Craniofacial Development


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: Biological systems are complex and hard to predict. My methods provide ways to quantify our uncertainty about them and design experiments to better understand them with less experiments. This will accelerate our understanding of biology, which will allow for new therapeutic applications to treat various diseases.

PI_NAMEs: ZABALLA, VINCENT DAVID (contact)

PROGRAM_OFFICER_NAME: STEPANEK, LAURIE ELIZABETH

PROJECT_TERMS: Ablation;Acceleration;Algorithm Design;Algorithms;Benchmarking;Binding;Biological;Biological Models;Biological Process;biological systems;Biology;bone;Bone Morphogenetic Proteins;Cell Line;cell type;Cells;Competitive Binding;Complex;complex biological systems;Computer software;computerized tools;Data;design;Development;Devices;Diffusion;Dimensions;Disease;Dose;Drug Design;Equipment;Experimental Designs;experimental study;Foundations;Future;Gene Expression;Growth Factor;high throughput screening;improved;in silico;Information Systems;Kinetics;Knowledge;learning strategy;Ligands;Link;Machine Learning;machine learning algorithm;machine learning method;machine learning model;Maintenance;Malignant Neoplasms;mathematical model;Mathematics;Methods;Microfluidics;Modeling;molecular dynamics;novel therapeutics;Output;Pathway interactions;Phenotype;Play;Rapid screening;receptor;receptor binding;Recommendation;response;Role;screening;Series;Signal Pathway;Signal Transduction;simulation;Source;System;Systems Biology;Techniques;Text;Time;Titrations;tool;Translating;tumor;Uncertainty;Work

PROJECT_TITLE: Characterization of a Droplet Microfluidic High Throughput Screening Device and Developing Machine Learning Algorithms to Study the Bone Morphogenetic Protein Signaling Pathway

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-U(20)L]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Women's Health Research

ORG_CITY: CHICAGO

ORG_DEPT: PHARMACOLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Triple-negative breast cancer (TNBC), which accounts for ~20% of all breast cancer cases, represents a breast cancer subtype with the poorest outcome. No molecularly targeted therapy has been FDA-approved to treat the vast majority of patients with TNBC, and approximately 35% of whom are expected to succumb to the disease each year. Our proposed study will utilize highly robust experimental approaches and is focused on preclinical identification and validation of novel and potentially life-saving targeted therapies for patients with TNBC.

PI_NAMEs: MENDILLO, MARC  (contact)

PROGRAM_OFFICER_NAME: KONDAPAKA, SUDHIR B

PROJECT_TERMS: Acute;Address;antitumor effect;biological adaptation to stress;Breast Cancer Cell;Breast Cancer cell line;Breast Cancer Patient;cancer stem cell;cancer subtypes;cancer type;Cell Death;Cell Survival;Cells;chemotherapy;Clinical;clinical development;Clinical Investigator;clinically relevant;Collaborations;Collection;Combined Modality Therapy;cytotoxicity;Death Rate;Disease;Disease Progression;Drug Combinations;Drug Screening;Drug Synergism;drug testing;druggable target;early experience;efficacy evaluation;efficacy study;Epidermal Growth Factor Receptor;Estrogen Receptors;Excision;Experimental Models;Family;FDA approved;Goals;Growth;Human;human model;Impairment;In Vitro;in vivo;inhibitor;kinase inhibitor;Life;Liquid substance;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Neoplasms;misfolded protein;molecular targeted therapies;mouse model;multicatalytic endopeptidase complex;Multiple Myeloma;neoplastic cell;novel;Oncogenic;Oncoproteins;Operative Surgical Procedures;Outcome;Outcomes Research;overexpression;oxidative damage;Oxidative Stress;Pathway interactions;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;Phase;Phosphotransferases;PIM1 gene;pre-clinical;Pre-Clinical Model;Progesterone Receptors;Proteasome Inhibition;Proteasome Inhibitor;Protein Inhibition;Protein Isoforms;Proteins;proteotoxicity;proto-oncogene protein pim;Radiation;rational design;Reactive Oxygen Species;receptor;Recurrent tumor;Reporting;Research;research clinical testing;Resistance;resistance mechanism;Sampling;screening;small molecule inhibitor;Solid;Solid Neoplasm;standard of care;stem-like cell;Stress;targeted treatment;Testing;therapy resistant;tool;transcription factor;Translating;treatment strategy;triple-negative invasive breast carcinoma;tumor;tumor growth;tumor xenograft;Up-Regulation;Validation;Xenograft Model

PROJECT_TITLE: Investigating Rational Combination Therapies for Triple-Negative Breast Cancer

STUDY_SECTION: DT

STUDY_SECTION_NAME: Developmental Therapeutics Study Section[DT]


ADMINISTERING_IC: MD

ED_INST_TYPE: SCHOOLS OF EDUCATION

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_DEPT: SOCIAL SCIENCES

PHR: Project Narrative Chinese American cancer survivors, one of the fastest growing immigrant groups in the US, are more likely to experience poorer mental health than their non-Hispanic White counterparts. The proposed study will evaluate the feasibility and preliminary efficacy of a culturally-tailored writing intervention that harnesses the potential benefits of peer helping and emotional disclosure for this population. Findings from the proposed study has important public health implications on reducing disparities in the psychological burden of cancer among Chinese Americans.

PI_NAMEs: TSAI, WILLIAM  (contact)

PROGRAM_OFFICER_NAME: JOHNSON, JARRETT AINSWORTH

PROJECT_TERMS: Address;anxiety symptoms;Area;Asia;Asian Americans;Award;Basic Science;Breast Cancer survivor;Cancer Burden;cancer diagnosis;cancer health disparity;Cancer Patient;cancer risk;cancer survival;Cancer Survivor;Cancer Survivorship;career;Cause of Death;Chinese;Chinese American;Chinese population;Cities;Clinic;Clinical;Collaborations;Communities;community based participatory research;community engaged research;community organizations;coping;cultural values;Data;depressive symptoms;Development;Disparity;disparity reduction;emotion regulation;emotional disclosure;Emotions;ethnic minority;evidence base;Evidence based intervention;experience;expressive writing;Fatigue;feasibility testing;Feedback;Focus Groups;follow-up;Fright;Future;Goals;Immigrant;implementation strategy;improved;Individual;informant;Intervention;Intervention Studies;Interview;Knowledge;Linguistics;Malignant Neoplasms;member;Mental Depression;Mental Health;Mentored Research Scientist Development Award;Mentors;Methods;Minority;Minority Health Research;Modeling;neoplasm resource;New York City;Not Hispanic or Latino;Oncologist;Oncology;Outcome;Participant;Patient Self-Report;peer;Personal Satisfaction;Population;Population Heterogeneity;post intervention;preference;primary outcome;Process;programs;psychologic;psychosocial adjustment;Public Health;Qualitative Research;Quality of life;Questionnaires;Randomized;Randomized, Controlled Trials;recruit;Reporting;Research;Resources;retention rate;secondary outcome;skills;social stigma;socioeconomics;Stress;Stressful Event;Testing;Training;Well in self;Work;Writing

PROJECT_TITLE: Helping Oneself by Helping Others: A Writing Intervention for Chinese American Cancer Survivors


NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Mental Health;Neurosciences;Post-Traumatic Stress Disorder (PTSD)

ORG_CITY: SYRACUSE

ORG_DEPT: PSYCHIATRY

ORG_NAME: UPSTATE MEDICAL UNIVERSITY

PHR: Significance and Health Relevance of Proposed Studies The research described in this proposal will shed new light on the synaptic and circuit mechanisms underlying memory discrimination and generalization, and may lead to new treatment strategies for neuropsychiatric disorders, such as PTSD and panic disorder, that are caused by the imbalance between memory discrimination and generalization.

PI_NAMEs: CASTILLO, PABLO E;LIN, YINGXI  (contact)

PROGRAM_OFFICER_NAME: CHURN, SEVERN BORDEN

PROJECT_TERMS: Adaptive Behaviors;Behavior;Behavioral;Brain;Brain-Derived Neurotrophic Factor;Cells;Data;dentate gyrus;Discrimination;Disease;Electrophysiology (science);entorhinal cortex;Equilibrium;experience;fear memory;Future;Gene Expression;Genetic Transcription;granule cell;Health;Individual;innovation;Interneurons;Lateral;Learning;Medial;Mediating;Memory;memory encoding;Modification;Molecular;Morphology;Neurons;neuropsychiatric disorder;novel;novel therapeutic intervention;NPAS4 gene;Output;Panic Disorder;Pathway interactions;Population;Post-Traumatic Stress Disorders;Process;recruit;Reporter;Research;research study;Role;Stimulus;Synapses;Synaptic plasticity;Time;transcriptome sequencing

PROJECT_TITLE: Activity-Dependent Transcriptional Pathways Underlying Synaptic Mechanisms for Memory Discrimination and Generalization.

STUDY_SECTION: SYN

STUDY_SECTION_NAME: Synapses, Cytoskeleton and Trafficking Study Section[SYN]


NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Heart Disease;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PHR: Narrative Current therapies slow but cannot reverse heart failure (>6M Americans), because they do not regenerate lost heart muscle. Here, we develop the first computational model of the biological circuits controlling heart muscle cell regeneration, focusing on a newly identified TGF-beta module. We experimentally test this model's ability to predict cell renewal and cardiac regeneration.

PI_NAMEs: SAUCERMAN, JEFFREY J. (contact);VAN BERLO, JOHANNES (JOP)

PROGRAM_OFFICER_NAME: ADHIKARI, BISHOW B

PROJECT_TERMS: Adult;Algorithms;American;Biological Assay;Biological Models;Candidate Disease Gene;Cardiac;Cardiac Myocytes;cardiac regeneration;Cardiology;Cell Cycle;Cell Differentiation process;cell regeneration;Cells;Computer Models;Data;Dedications;Development;DNA biosynthesis;experience;Experimental Models;experimental study;Future;gene discovery;Genes;genome-wide;Heart;Heart failure;Hematopoietic System;Human;human induced pluripotent stem cells;Image;In Vitro;in vivo;in vivo regeneration;induced pluripotent stem cell derived cardiomyocytes;Injury;innovation;insight;knock-down;Life;Literature;live cell microscopy;Liver;Logic;Mammals;Measures;Methodology;Methods;Modeling;Molecular;Molecular Biology;molecular modeling;mouse model;Mus;Myocardium;Natural regeneration;neonatal period;network models;novel;Organ;organ regeneration;Outcome;Pancreas;Pathway interactions;Phenotype;Population;postnatal development;predictive modeling;prenatal;Prevalence;Proliferating;Proteins;regeneration following injury;regeneration potential;regenerative;regenerative therapy;Regulation;Reproducibility;screening;Signal Transduction;Skeletal Muscle;stem cell differentiation;stem cells;System;Testing;Therapeutic;therapeutic candidate;therapeutic target;Transforming Growth Factor beta;Validation;Work

PROJECT_TITLE: Computational and Experimental Modeling of Cardiomyocyte Proliferation

STUDY_SECTION: MABS

STUDY_SECTION_NAME: Modeling and Analysis of Biological Systems Study Section[MABS]


ED_INST_TYPE: SCHOOLS OF OSTEOPATHIC MEDICINE

NIH_SPENDING_CATS: Aging;Atherosclerosis;Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease;Prevention

ORG_CITY: OLD WESTBURY

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: NEW YORK INST OF TECHNOLOGY

PHR: PROJECT NARRATIVE Heart disease causes one in four deaths in the United States. Since vascular calcification is a strong predictor of future heart disease and/or death from heart disease, this project will determine whether calcification is not only a risk factor for atherosclerosis, but also involved in the pathogenesis and propagation of this disease. The proposed study will benefit public health by providing potential new therapeutic avenues that complement lipid-lowering approaches to improve outcomes for millions of Americans.

PI_NAMEs: SAVINOVA, OLGA V. (contact)

PROJECT_TERMS: Ablation;Acceleration;Adverse effects;Alkaline Phosphatase;American;Aorta;Area;Arterial Fatty Streak;Arteries;athero susceptible;Atherosclerosis;Attention;Benign;Biological Availability;bone;Bone remodeling;Breast Microcalcification;calcification;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;Cardiovascular system;care costs;Cause of Death;cell type;Cells;Cessation of life;Cholesterol;Complement;Computer Models;Computer software;Coronary Arteriosclerosis;Coupled;Data;Development;Disease;Elasticity;Endothelial Cells;Endothelium;experimental study;Familial Hypercholesterolemia;Future;General Population;Genetic;Genetic Recombination;Geometry;Goals;Heart Diseases;hemodynamics;Histologic;Human;human model;Hydroxyapatites;Hyperglycemia;Hypertension;image guided;improved;improved outcome;in vivo;in vivo Model;Infusion procedures;Label;Left Ventricular Ejection Fraction;Lipids;Lipoproteins;Liquid substance;Low Density Lipoprotein Receptor;Low-Density Lipoproteins;Macrophage;Measures;Mediating;Methods;microCT;Microscopic;Modeling;modifiable risk;Monitor;Morbidity - disease rate;mortality;Motion;mouse model;Mus;mutant;Nodule;novel;novel therapeutics;Oral;osteogenic;Outcome;overexpression;particle;Pathogenesis;Patients;Phase;Phenotype;phosphatase inhibitor;Physics;Plasma;Play;Preparation;preservation;Public Health;Resolution;response;Risk;Risk Factors;risk stratification;Role;Rupture;shear stress;side effect;small molecule;Structure;Surface;targeted treatment;Testing;Texture;Therapeutic;therapeutic development;therapeutic target;thrombotic complications;Time;Tissues;United States;uptake;Vascular calcification;Virulence Factors;Visualization;Work

PROJECT_TITLE: Vascular calcification and atherosclerosis

STUDY_SECTION: AICS

STUDY_SECTION_NAME: Atherosclerosis and Inflammation of the Cardiovascular System Study Section[AICS]


ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Exercise has been shown to improve the prognosis of numerous tumor types in rodents and humans, but the mechanism by which the beneficial effects of exercise are accomplished is unknown. Unraveling this mechanism is important because it may reveal new therapeutic targets for cancer. In this project we will explore a proposed mechanism by which exercise diverts sugar from tumor cells to muscle and immune cells, and thereby primes the immune system to slow tumor growth in mouse models of lung cancer.

PI_NAMEs: PERRY, RACHEL JAMISON (contact)

PROGRAM_OFFICER_NAME: XI, DAN

PROJECT_TERMS: Acute;Affect;anti-cancer;Antiinflammatory Effect;awake;blood glucose regulation;Cancer cell line;cancer recurrence;cancer type;Cell Communication;Cell division;Cell Physiology;Cells;Cellular Metabolic Process;Characteristics;Chronic;Clinical;Clinical Research;Clinical Trials Design;Complement;cytokine;Data;Dose;Down-Regulation;driver mutation;epidemiology study;evidence base;Exercise;exercise intensity;exercise prescription;exercise regimen;exercise rehabilitation;exercise training;exhaustion;Failure;fatty acid metabolism;Genetic;Glucose;glucose metabolism;glucose uptake;Glycolysis;Growth;Hour;Human;IL6 gene;Immune;immune activation;immune function;Immune system;immunogenic;immunoregulation;Immunotherapy;improved;In Vitro;in vivo;Incidence;Infiltration;Inflammation;Inflammatory;Infusion procedures;inhibitor;insight;Insulin;Interval training;Knock-out;Knockout Mice;Link;lung cancer cell;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant Neoplasms;Mediating;Metabolic;Metabolism;Methods;mode of exercise;Modeling;mouse model;Mus;Muscle;Muscle Cells;Myelogenous;Myeloid Cells;Myomatous neoplasm;neoplastic cell;new therapeutic target;Obesity;oxidation;Pathologic;Patients;Performance;physiologic model;Population;precision medicine;prevent;process optimization;Production;Prognosis;Regimen;Resolution;response;Risk Reduction;Rodent;Role;Running;SLC2A1 gene;standard of care;Strenuous Exercise;sugar;T-Cell Activation;T-Lymphocyte;Testing;Tissue Model;Tissues;Training;treadmill;tumor;tumor growth;Tumor Immunity;tumor metabolism;tumor progression;Veins;Work

PROJECT_TITLE: Exercise and Lung Cancer


NIH_SPENDING_CATS: Breast Cancer;Cancer;Estrogen;Orphan Drug;Rare Diseases;Women's Health Research

ORG_CITY: HOUSTON

ORG_NAME: METHODIST HOSPITAL RESEARCH INSTITUTE

PHR: Project narrative Our proposal aims to determine whether estrogen receptor β (ERβ) prevents progression and metastasis of inflammatory breast cancer (IBC) and demonstrate its potential as novel therapeutic target. Our research will assist to better understand why IBC tumors become metastatic. It will also validate the ERβ ligands as a new therapeutic compound that either alone or in combination with current therapies may substantially repress IBC metastasis and eliminate its associated mortality.

PI_NAMEs: THOMAS, CHRISTOFOROS  (contact)

PROGRAM_OFFICER_NAME: WOODHOUSE, ELIZABETH

PROJECT_TERMS: Actins;Affect;Age;aggressive breast cancer;Agonist;AKT1 gene;Architecture;Biology;Breast Cancer Cell;breast cancer metastasis;Breast Cancer Patient;Cell Adhesion;Cell Culture System;Cell Line;cell motility;Cell Physiology;Cells;Clinical;Clinical Treatment;Clinical Trials;Combined Modality Therapy;Cytoskeleton;Data Set;differential expression;Disease;Disease Progression;Distant Metastasis;efficacy evaluation;Ensure;Epithelium;ESR1 gene;Estrogen Receptor 2;Estrogens;FDA approved;Foundations;G-Protein-Coupled Receptors;Genes;genetic profiling;Grant;Guanine Nucleotide Exchange Factors;Human;improved;In Vitro;in vivo;Incidence;inflammatory breast cancer;innovation;insight;Invaded;Knock-out;Ligands;lung colonization;Malignant Breast Neoplasm;Malignant Neoplasms;Mediating;metastatic process;migration;Modeling;Molecular;Molecular Profiling;mortality;Motility;Neoplasm Metastasis;new therapeutic target;Newly Diagnosed;Nonmetastatic;novel;novel therapeutics;Oncogenic;Outcome;overexpression;Pathway interactions;Patients;Pattern;Pharmaceutical Preparations;Phenotype;Phosphorylation;Pre-Clinical Model;preclinical study;prevent;Preventive treatment;Prognosis;Reagent;receptor;Receptor Activation;receptor expression;Reporting;Repression;Research;rho GTP-Binding Proteins;Role;Sampling;Signal Pathway;Signal Transduction;Specimen;targeted treatment;therapeutic target;Translating;tumor;Tumor Tissue;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Exploring the role of estrogen receptor beta in progression and metastasis ofInflammatory breast cancer

STUDY_SECTION: TME

STUDY_SECTION_NAME: Tumor Microenvironment Study Section[TME]


ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE Using the model organism Drosophila melanogaster, this project seeks to determine fundamental dynamics of complex traits and rapid adaptation in natural populations. Understanding the genetic basis and evolution of complex traits in a model system is applicable to similarly complex traits in other systems that are not amenable to direct experimentation. The causes, mechanisms and consequences of rapid adaptation is of direct relevance to a number of biological phenomena including evolution of and evolutionary response to viruses, vector-borne disease, antibiotic resistance, dynamics of cancer, and evolution in a changing environment.

PI_NAMEs: MCINTYRE, LAUREN M.;SCHMIDT, PAUL  (contact)

PROGRAM_OFFICER_NAME: ADKINS, RONALD

PROJECT_TERMS: Abdomen;Affect;Alleles;Allelic Imbalance;Antibiotic Resistance;Back;Bacterial Infections;Biological;Biological Models;Biological Phenomena;Biology;Capsicum;Color;Complex;Darkness;Data;Development;Drosophila genus;Drosophila melanogaster;Drug resistance;Environment;Evolution;Exhibits;experimental study;Exposure to;fitness;fly;Frequencies;Gene Frequency;Generations;Genes;Genetic;genetic architecture;genetic resource;genetic variant;Genetic Variation;Genome;Global Change;Goals;Humanities;Inbreeding;innovation;insight;Knowledge;Learning;Life Cycle Stages;Light;Malignant Neoplasms;model organism;Modeling;Molecular;Moths;Mus;Mutation;Natural Selections;North America;novel;Outcome;Pattern;Periodicity;pesticide resistance;Phenotype;Pigmentation physiologic function;pleiotropism;Population;Process;Quantitative Genetics;Regulation;response;Seasonal Variations;Seasons;Site;Surveys;System;Temperature;Testing;trait;transcription factor;Translating;translational impact;Variant;Vector-transmitted infectious disease;viral pandemic;Virus;Virus Diseases;Work

PROJECT_TITLE: Rapid evolution of pigmentation in D. melanogaster: from cis regulation to phenotype

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-GGG-Z(02)M]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Autoimmune Disease;Cancer;Colorectal Cancer;Complementary and Integrative Health;Dietary Supplements;Digestive Diseases;Genetics;Inflammatory Bowel Disease;Natural Products;Nutrition;Prevention

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

PHR: NARRATIVE  The purpose of this project is to address the issue of alternative and impactful options for patients with Inflammatory Bowel Disease (IBD) to both treat their disease and prevent colon cancer that can result from long- standing and uncontrolled IBD. In comparing innovative treatment strategies, panaxynol (PA; isolated from American Ginseng) stands out as our most potent molecule tested; and we are exploring a unique mechanism that might not only elucidate colitis mechanisms and cures, but branch into other diseases driven by dysregulated mΦ function. The results of this project will lead to clinical trials and the standardization of PA as a stand-alone product, or as part of a synergistic combination therapy for patients with IBD.

PI_NAMEs: HOFSETH, LORNE J (contact);MURPHY, ELIZABETH ANGELA

PROGRAM_OFFICER_NAME: PERLOFF, MARJORIE

PROJECT_TERMS: Ablation;Address;Affect;American;Animal Model;Animals;anti-cancer;Anti-Inflammatory Agents;anticancer activity;Apoptosis;Area;Autoimmune Diseases;Biological Assay;Biomedical Engineering;cancer chemoprevention;cell type;Cells;cellular targeting;Chemicals;Chemoprevention;Chemopreventive Agent;Clinical;Clinical Trials;Coculture Techniques;Colitis;Colon;colon cancer prevention;colon cancer risk;Colon Carcinoma;Combined Modality Therapy;Complementary and alternative medicine;conditional knockout;conventional therapy;cost;Crohn's disease;Dangerousness;dextran sulfate sodium induced colitis;Disease;DNA;DNA Damage;Dose;Drug Kinetics;Economic Burden;Effectiveness;efficacy testing;Europe;experimental study;Exposure to;FDA approved;Fractionation;Functional disorder;Genetically Engineered Mouse;Genome;Ginseng Preparation;Goals;Immune;improved;in vivo;Induction of Apoptosis;Infiltration;Inflammatory;Inflammatory Bowel Diseases;innovation;Intestines;Knowledge;Lead;Life Style;LoxP-flanked allele;Macrophage;Malignant Neoplasms;Mediating;microbiota;Modeling;Molecular;murine colitis;Mus;Myeloid Cells;Natural Compound;Natural Source;Nature;North America;novel;p53 Signaling Pathway;Pathway interactions;Patients;Persons;Pharmaceutical Preparations;pharmacologic;Plants;Prevalence;Property;replication stress;Research;response;Resveratrol;Sepsis;sex;side effect;Signal Pathway;Signal Transduction;single molecule;SIRT1 gene;small molecule;sound;Standardization;Testing;TNF gene;Toxic effect;TP53 gene;Treatment outcome;treatment strategy;Ulcerative Colitis

PROJECT_TITLE: Harnessing the power of p53 with Panaxynol from American Ginseng to suppress colitis and prevent colon cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-T(02)M]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Colorectal Cancer;Digestive Diseases;Orphan Drug;Pancreatic Cancer;Rare Diseases

ORG_CITY: DETROIT

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: WAYNE STATE UNIVERSITY

PHR: PROJECT NARRATIVE We discovered novel compounds targeting a critical mitochondrial enzyme (SHMT2) with secondary inhibition of cytosolic nucleotide biosynthesis that represent an entirely new approach for treating cancer. Our objective is to optimize lead structures for tumor targeting and inhibition of mitochondrial and cytosolic metabolism at modest doses with minimal toxicity. This collaboration between experts in medicinal chemistry, molecular pharmacology of anti-cancer drugs, x-ray crystallography and structural biology, pharmaceutics, in vivo mouse models of cancer, and clinical care of patients with pancreatic cancer is rare in academic research into targeted cancer drug discovery. Our proposed studies will provide the important groundwork for further preclinical studies leading to an IND application for these novel molecules.

PI_NAMEs: DANN, CHARLES E.;GANGJEE, ALEEM ;MATHERLY, LARRY H (contact)

PROGRAM_OFFICER_NAME: GREENBERG, WILLIAM A

PROJECT_TERMS: Acute;advanced disease;Anabolism;analog;anti-tumor agent;Antineoplastic Agents;Biological Assay;cancer care;cancer cell;Cancer cell line;Carbon;Cell membrane;Cells;Characteristics;clinical care;Clinical Trials;clinically relevant;Collaborations;Colon Carcinoma;Colorectal Cancer;Coupled;Cytosol;Development;Disease;Disease remission;Dose;Drug Delivery Systems;drug discovery;Drug Kinetics;drug metabolism;Drug Transport;efficacy trial;Enzymes;Epithelial Cells;Epithelial ovarian cancer;Equilibrium;Evaluation;Exhibits;FDA approved;FRAP1 gene;gemcitabine;Genetically Engineered Mouse;Glutathione;Glycine;glycine amide;Glycine Hydroxymethyltransferase;Human;Hydroxymethyltransferases;Hypoxia;In complete remission;In Vitro;in vivo;in vivo evaluation;inhibitor;KPC model;KRAS2 gene;Lead;lead optimization;Malignant neoplasm of pancreas;Malignant Neoplasms;Measures;Metabolic;Metabolic Pathway;Metabolism;metabolomics;Mitochondria;mitochondrial therapeutics;Modeling;Molecular;mouse model;Mus;mutant;nanomolar;new therapeutic target;Non-Small-Cell Lung Carcinoma;novel;novel strategies;Nucleotide Biosynthesis;Nutrient;Oxidation-Reduction;Pancreas;pancreatic cancer cells;pancreatic cancer model;pancreatic cancer patients;Partial Remission;Pathway interactions;Patient Care;patient derived xenograft model;Pemetrexed;Pharmaceutical Chemistry;Pharmacology;Pharmacy (field);preclinical study;Prognostic Factor;Proliferating;Protons;prototype;Purines;Pyrimidine;Reactive Oxygen Species;Recovery;Regulation;Research;Respiration;Ribonucleotides;Role;Series;Serine;Severe Combined Immunodeficiency;Signal Transduction;SLC19A1 gene;Source;standard of care;structural biology;Structure;Survivors;Testing;therapeutic target;thymidylate;Time;Toxic effect;Transplantation;tumor;tumor growth;tumor microenvironment;uptake;X-Ray Crystallography;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Therapeutic Targeting Mitochondrial C1 Metabolism

STUDY_SECTION: DMP

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology Study Section[DMP]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Contraception/Reproduction;Heart Disease;Hypertension;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Women's Health Research

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF CHICAGO

PHR: PROJECT NARRATIVE Preeclampsia (PE) is a hypertensive disorder that affects 5-10% of all pregnant women and is the most common medical complication of pregnancy. Although PE was previously considered only a peripartum disease, it is now recognized as a prominent risk factor for the development of cardiovascular disease (CVD). Our interdisciplinary research team will conduct a randomized controlled trial to test whether aspirin improves, cardiac function, while building exploring the fundamentals mechanism of why and how this cardiac dysfunction occurs.

PI_NAMEs: SHAHUL, SAJID  (contact)

PROGRAM_OFFICER_NAME: REID, DIANE M

PROJECT_TERMS: activin A;Activin A type II receptor;Activins;Affect;Aging;Animal Model;antagonist;Aspirin;Basic Science;Binding;Blood;Cardiac;Cardiovascular Diseases;Cardiovascular system;Cell Differentiation process;Cell Proliferation;Cell surface;cell type;Cells;Cessation of life;Clinical;Clinical Trials;coronary fibrosis;Data;Development;Disease;double-blind placebo controlled trial;Echocardiography;experimental study;Family;Fibrosis;Functional disorder;Future;Glycoproteins;Growth Factor;Heart;Heart failure;heart function;heparanase;Heparitin Sulfate;Human;Hybrids;Hypertension;improved;Incidence;Inflammatory;Infusion procedures;innovation;Interdisciplinary Study;Investigation;Knowledge;Late pregnancy;Lead;Macrophage;Measures;Mediating;medical complication;member;Meta-Analysis;Methodology;Modeling;Molecular;Molecular Target;Morbidity - disease rate;mortality;Myocardial dysfunction;Myocardial Ischemia;novel;Organ;Outcome;Pathology;Pathway interactions;Patients;Perfusion;Perinatal;Pharmaceutical Preparations;Placebos;Placenta;Plasma;postpartum complications;Postpartum Period;Pre-Clinical Model;Pre-Eclampsia;Pregnancy;Pregnancy Complications;pregnant;Pregnant Women;pressure;prevent;Prevention;Public Health;Randomized;randomized trial;Randomized, Controlled Trials;Rattus;Recording of previous events;Research;Risk Factors;Second Pregnancy Trimester;Signal Transduction;Systolic heart failure;Testing;Transforming Growth Factor beta;United States;Uterus;Woman;Women's mortality;women's treatment

PROJECT_TITLE: Aspirin to prevent cardiac dysfunction in preeclampsia

STUDY_SECTION: CICS

STUDY_SECTION_NAME: Clinical and Integrative Cardiovascular Sciences Study Section[CICS]


NIH_SPENDING_CATS: Aging;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Hypertension;Neurosciences;Postural Orthostatic Tachycardia Syndrome

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Project Narrative Public Health Relevance Statement Neurogenic orthostatic hypotension (nOH) is a significant clinical problem in the elderly and an unmet medical need. We have developed an automated abdominal binder that, unlike pressor agents, selectively improves upright blood pressure without inducing or worsening lying down high blood pressure. The results of these studies will provide the mechanistic insight to foster the efforts currently under way to develop more targeted treatments for nOH.

PI_NAMEs: OKAMOTO, LUIS ENRIQUE (contact)

PROJECT_TERMS: Abdomen;Accelerometer;Acute;Aftercare;Age;Aorta;arterial stiffness;autonomic reflex;Blood Pressure;blood pressure control;blood pressure reduction;cardiovascular risk factor;Caregivers;Circulation;Clinical;comorbidity;Compensation;Continuous Positive Airway Pressure;Devices;disability;Disabling;Diuresis;Drops;Elderly;Electric Capacitance;electric impedance;fall risk;falls;Femur;Fostering;Functional disorder;Goals;hemodynamics;Hour;Human;human old age (65+);Hypertension;Impairment;improved;Incidence;indexing;insight;Knee;Manuals;Measures;Medical;Midodrine;mortality;Musculoskeletal Equilibrium;neurogenic orthostatic hypotension;new technology;novel;novel strategies;novel therapeutics;Orthostatic Hypotension;Patient Compliance;Patients;Pharmaceutical Preparations;Pharmacotherapy;Physiologic pulse;Play;Population;positive airway pressure;Posture;pressure;public health relevance;Quality of life;Risk Factors;Role;Splanchnic Circulation;standard of care;Stroke Volume;Supination;Techniques;Testing;therapeutically effective;therapy development;Thigh structure;treatment comparison;Venous

PROJECT_TITLE: Automated Abdominal Binder for Orthostatic Hypotension


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: Project narrative Eukaryotic genomes can consist in large part of abundant tandemly repeated sequences called satellite DNAs. Despite the important effects of satellite DNA on genome evolution, speciation, genomic instability and cancer, we know little about their functions or evolution. Studying the evolutionary and functional genomics of satellite DNA will help us identify important satellites and understand how their expression and regulation affects cellular functions.

PI_NAMEs: LARRACUENTE, AMANDA MARIE (contact)

PROJECT_TERMS: Affect;Aging;Behavioral Genetics;Cell Physiology;Centromere;Chromatin;Chromosome Segregation;comparative genomics;CRISPR/Cas technology;Cytology;Data;Development;DNA Sequence;driving force;Drosophila genome;Drosophila melanogaster;Evolution;experimental study;fitness;functional genomics;gene-editing approach;Genetic;genetic manipulation;Genetic Models;genetic resource;Genome;genome editing;genome resource;Genome Stability;Genomic approach;Genomic Instability;genomic locus;Genomics;Malignant Neoplasms;Methods;Molecular;Molecular Genetics;Natural Selections;Population Genetics;Regulation;Resolution;Satellite DNA;Sequence Deletion;Site;Tandem Repeat Sequences;Techniques;Technology;telomere;Testing;Time;tool;Untranslated RNA;Y Chromosome

PROJECT_TITLE: The evolutionary and functional genomics of satellite DNA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


NIH_SPENDING_CATS: Cancer;Clinical Research;Data Science;Health Services;Lung;Lung Cancer;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety

ORG_CITY: DAVIS

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Cancer continues to rank as the second leading cause of death in the US. We propose to apply novel machine learning and visual analytics methods to study how teamwork, specifically communication and information sharing among large numbers of healthcare professionals, impact their patients' outcome.

PI_NAMEs: MA, KWAN-LIU  (contact);TU, SHIN-PING

PROGRAM_OFFICER_NAME: RANDHAWA, GURVANEET

PROJECT_TERMS: Academy;Address;analytical method;analytical tool;Big Data;Breast;cancer care;cancer diagnosis;Cancer Patient;cancer therapy;Caring;Cause of Death;Center for Translational Science Activities;Cessation of life;Clinical;Clinical Sciences;Collaborations;Colorectal;Communication;Communications Media;Complex;Computer software;Coupling;Creativeness;Data;Data Analytics;Data Science;design;digital;Discipline;disease diagnosis;Effectiveness;Electronic Health Record;electronic health record system;evidence base;explainable artificial intelligence;flexibility;Future;Growth;health care delivery;health care settings;Health Professional;Healthcare;improved;Individual;information processing;interdisciplinary collaboration;Libraries;Location;Machine Learning;machine learning method;Malignant Neoplasms;Mediating;Medical Care Team;Medicine;Mentors;Methods;minority student;mortality;National Cancer Institute;Non-Small-Cell Lung Carcinoma;novel;open source;Pathway Analysis;Patient-Focused Outcomes;Patients;Performance;Persons;Problem Solving;Process;programs;Reporting;Research;Research Activity;Role;Structure;support tools;System;Systems Theory;Technology;undergraduate research;undergraduate student;Validation;virtual healthcare;Visual;Visualization;Work

PROJECT_TITLE: SCH: Smart EHR Data Analytics to Enhance Cancer Care Multiteam Systems

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-VH-N(50)R]


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Crohn's Disease;Dietary Supplements;Digestive Diseases;Inflammatory Bowel Disease;Microbiome;Nutrition;Prevention

ORG_CITY: CLEVELAND

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative Crohn’s disease (CD) is a chronic, commonly disabling disorder of the gastrointestinal tract that is associated with imbalances in the composition of gut bacteria (‘dysbiosis’), and affects more than 600,000 individuals in the US. Gut bacteria modulation via diet is a needed strategy for the treatment and prevention of CD; however, no specific recommendations exist for CD patients, and little is known about the complex interaction between dietary nutrients, gut bacteria and host immune responses. Understanding these interactions, particularly how specific dietary factors can alleviate disease symptoms through their effect on the composition of gut bacteria, will allow us to develop novel therapeutic approaches to treat, prevent, and ultimately cure the disease.

PI_NAMEs: RAFFNER, ABIGAIL  (contact)

PROGRAM_OFFICER_NAME: OSGANIAN, VOULA

PROJECT_TERMS: Affect;American;Amino Acids;Animals;Anti-Inflammatory Agents;Antiinflammatory Effect;Area;Bioinformatics;Biological Markers;biomarker identification;Blood;career;Chronic;clinical biomarkers;Clinical Medicine;Colitis;Complex;Crohn's disease;Data;Diet;dietary;Dietary Factors;Dietary Intervention;Dietary Supplementation;Dietitian;Digestive System Disorders;Disabling;Disease;Disease remission;disorder control;disorder subtype;Doctor of Philosophy;dysbiosis;Eating;Environmental Risk Factor;Etiology;fecal transplantation;Feces;Functional disorder;Future;germ free condition;Germ-Free;Glycine;Goals;Grant;gut bacteria;gut homeostasis;gut inflammation;gut microbiome;gut microbiota;Health;Human;Ileitis;Immune;Immune response;Immunologics;Immunology;improved;Individual;Inflammatory;Inflammatory Bowel Diseases;Inflammatory Response;Intervention Studies;Investigation;Isoleucine;Leucine;Mass Spectrum Analysis;Mediating;Metabolic;Metabolic Pathway;metabolic profile;Metabolism;metabolome;metatranscriptome;Methionine;microbial;microbiome;microbiota;microbiota profiles;Modeling;Modification;Monitor;mouse model;Mus;National Health and Nutrition Examination Survey;novel therapeutic intervention;Nutrient;open label;oral supplementation;Pathogenesis;Patients;Persons;Phenotype;Plasma;prevent;Prevention;Probiotics;Proteins;Randomized;Rapid screening;Recommendation;Relapse;Reporting;Reproducibility;Research;response;Rodent;SAMP mouse;Severities;soy;stool sample;Supplementation;Surveys;Symptoms;Testing;Therapeutic;Threonine;Time;transcriptomics;Translating;Transplantation;treatment strategy;Urine;Valine;Virulence;Work

PROJECT_TITLE: Effect of an Anti-Inflammatory Diet on Gut Homeostasis in Active and Experimental Crohn's Disease

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


ORG_CITY: BALTIMORE

ORG_DEPT: NEUROLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Adoptive T cell therapy has offered remarkable treatment successes for several cancers but the clinical implementation of this promising therapy has been hampered by the development of life-threatening immunotoxicities, such as cytokine-release-syndrome (CRS). We recently identified that catecholamines produced by macrophages contribute to the development of CRS. The proposed research aims to determine how catecholamines modulate macrophage function and cytokine release induced by CART cells in mice and human. !

PI_NAMEs: BAI, RENYUAN ;STAEDTKE, VERENA  (contact)

PROGRAM_OFFICER_NAME: LIU, YIN

PROJECT_TERMS: Adrenergic Agents;Adrenergic Receptor;alpha-Methyltyrosine;anakinra;antagonist;Antitumor Response;B lymphoid malignancy;Biological Assay;Cancer Patient;cancer therapy;Catecholamines;CD14 gene;CD19 gene;Cell Therapy;Cells;chimeric antigen receptor;chimeric antigen receptor T cells;Clinical;clinical implementation;Coculture Techniques;CRISPR/Cas technology;cytokine;cytokine release syndrome;Data;data sharing;Dedications;Development;effective intervention;Epinephrine;Functional disorder;Genetic;Goals;Granulocyte-Macrophage Colony-Stimulating Factor;Hematologic Neoplasms;Human;IL6 gene;Immune;immune activation;immune function;Immune response;immune-related adverse events;Immunosuppression;Immunotherapy;immunotoxicity;improved;In Vitro;in vivo;in vivo evaluation;indexing;Individual;Inflammatory;inhibitor;Institution;Interleukin-6;knock-down;Knock-out;Knockout Mice;Laboratories;leukemia;Life;Macrophage;Macrophage Activation;Malignant Neoplasms;Measures;Mediating;Mediator;Modeling;Molecular;mortality;mouse model;Mus;Myelogenous;Myeloid Cells;neoplastic cell;NOS2A gene;novel;Pathogenesis;Patient Monitoring;Patient-Focused Outcomes;Patients;Pennsylvania;Peripheral Blood Mononuclear Cell;pharmacologic;Prazosin;prevent;Production;Productivity;receptor;Receptor Signaling;Research;response;Role;Safety;Sampling;Scientist;Serum;Severities;Shapes;small hairpin RNA;Solid Neoplasm;success;Supportive care;Symptoms;T cell response;T cell therapy;T-Lymphocyte;Therapeutic;therapy outcome;TNFSF5 gene;tool;Toxic effect;translational potential;tumor;tumor eradication;Tyrosine 3-Monooxygenase;United States National Institutes of Health

PROJECT_TITLE: Adrenergic modulation of cellular immune functions in CAR T cell-induced cytokine release syndrome


NIH_SPENDING_CATS: Biotechnology;Cancer;Gene Therapy;Genetics;Immunization;Immunotherapy;Lymphatic Research;Prevention;Vaccine Related

ORG_CITY: CAMBRIDGE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

PHR: Project Narrative: Using no more than two or three sentences, describe the relevance of this research to public health. In this section, be succinct and use plain language that can be understood by a general, lay audience. Immunotherapy using the transfer of a patient’s own T cells genetically modified to attack tumors is showing great promise in clinical trials, but faces several challenges to reach its full potential in the treatment of solid tumors. In this project, we propose to develop a strategy to “vaccinate” transferred T cells, boosting their expansion and function in patients to increase the safety and efficacy of this promising cancer immunotherapy.

PI_NAMEs: IRVINE, DARRELL J (contact)

PROGRAM_OFFICER_NAME: SOMMERS, CONNIE L

PROJECT_TERMS: Address;Adjuvant;Adoptive Cell Transfers;Adoptive Transfer;Albumins;amphiphilicity;Animals;Antigen Presentation;Antigen-Presenting Cells;Antigens;Binding;Biodistribution;Biological Models;Blood;Blood Circulation;booster vaccine;cancer immunotherapy;CAR T cell therapy;Cell Count;Cell Culture Techniques;Cell membrane;Cell Therapy;Cells;chimeric antigen receptor;chimeric antigen receptor T cells;Clinical;Clinical Trials;design;Disease remission;Dose;draining lymph node;Engraftment;Ensure;Exhibits;Face;Fluorescein-5-isothiocyanate;genetically modified cells;Hematologic Neoplasms;Human;Immune system;Immunization;Immunocompetent;Immunotherapy;in vivo;Injections;Investments;Language;leukemia/lymphoma;Licensure;Ligands;Lipids;Lymph;lymph nodes;Melanoma;Membrane;Memory;Molecular;Molecular Chaperones;Molecular Target;mouse model;neoplastic cell;Patients;peptide amphiphiles;Peptide Vaccines;Peptides;Phenotype;Phospholipids;Polymers;Population;Property;Public Health;receptor;Regimen;Rejuvenation;Research;response;Role;Safety;safety assessment;Secondary Immunization;Solid Neoplasm;success;Surface Antigens;synthetic biology;System;T cell response;T cell therapy;T-Lymphocyte;technology platform;Testing;Therapeutic;Toxic effect;tumor;uptake;Vaccinated;Vaccination;Vaccine Adjuvant;Vaccines

PROJECT_TITLE: Enhancing CAR-T cell activity against solid tumors by vaccine boosting through the chimeric receptor

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-H(02)M]


NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_CITY: SEATTLE

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative Necroptosis is a new form of programmed cell death that plays a critical role in cardiac ischemic injury, pathological remodeling, and heart failure progression. This proposal investigates a novel K63-ubiquitination dependent mechanism that regulates myocardial necroptosis, ischemic injury, and pathological remodeling, aiming to develop new anti-necroptotic strategies for ischemic heart disease.

PI_NAMEs: LIU, QINGHANG  (contact)

PROGRAM_OFFICER_NAME: TJURMINA, OLGA A

PROJECT_TERMS: Ablation;Acute;Adult;Apoptosis;Attenuated;Biological;Cardiac;Cardiac Myocytes;cardioprotection;Caspase;Cell Death Signaling Process;Cell membrane;Cessation of life;Complex;Data;Dilated Cardiomyopathy;Disease;Enzymes;experimental study;gain of function;Gene Transfer;Genetic;Goals;Heart;Heart failure;Heart Injuries;in vivo;Inflammation;insight;Investigation;Ischemia;ischemic injury;Link;loss of function;MAP3K7 gene;Mediating;Mitochondria;Modeling;Molecular;Mus;Myocardial;myocardial injury;Myocardial Ischemia;Necrosis;novel;Organelles;overexpression;Pathologic;Pathway interactions;Phosphorylation;Physiology;Pilot Projects;Play;Polyubiquitination;prevent;Process;receptor;Regulation;Reperfusion Injury;RIPK1 gene;RIPK3 gene;Role;Signal Transduction;Swelling;Testing;Therapeutic;therapeutic target;TNF receptor-associated factor 2;TNFRSF1A gene;ubiquitin isopeptidase;ubiquitin ligase;ubiquitin-protein ligase;Ubiquitination;vector

PROJECT_TITLE: A K63-Ubiquitination Dependent Necroptosis Signaling Network in the Heart

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CVRS-A(05)]


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD)

ORG_DEPT: CHEMISTRY

ORG_NAME: HARVARD UNIVERSITY

ORG_STATE: MA

PHR: PROJECT NARRATIVE ACTL6A and ACTL6B are mammalian proteins that regulate gene expression and have been implicated in cancer and developmental disorders. The interactions of ACTL6A and ACTL6B with chromatin remodeling complexes and other binding partners, the regions on the nuclear proteins that are important for their proper functioning, and their biochemical activities in regulating gene expression in healthy and disease settings remain incompletely understood. The studies proposed here will provide a comprehensive biochemical and molecular framework that may have utility in the development of new therapeutic opportunities for diseases driven by mutations in ACTL6A or ACTL6B subunits, and more broadly, the mSWI/SNF family of chromatin remodeling complexes.

PI_NAMEs: DEL RIO PANTOJA, JOSE  (contact)

PROJECT_TERMS: Actins;ACTL6A gene;ACTL6B gene;Advocacy;Amino Acids;Aminoacylation;Architecture;ATAC-seq;ATP Hydrolysis;ATP phosphohydrolase;Binding;Binding Proteins;Biochemical;Biochemistry;Biological Assay;Biology;Cells;Central Nervous System;ChIP-seq;Chromatin;chromatin remodeling;Chromatin Remodeling Factor;Communication;Complex;crosslink;Cryoelectron Microscopy;Data;Dedications;Development;developmental disease;differential expression;Disease;DNA;DNA sequencing;engineered stem cells;exome sequencing;Family;Frequencies;functional genomics;Gene Expression;Gene Expression Profile;Gene Expression Regulation;Generations;Genes;Genetic study;Genome;genome-wide;Genomics;Histone H3;Histones;human disease;Human Genome;induced pluripotent stem cell;insight;Intellectual functioning disability;Laboratory Research;Leadership;Link;Malignant Neoplasms;Mass Spectrum Analysis;Molecular;Molecular Machines;mutant;Mutation;Neurodevelopmental Disorder;Neuronal Differentiation;new therapeutic target;novel therapeutics;Nuclear Proteins;Nucleosomes;paralogous gene;protein complex;Protein Region;Protein Subunits;Proteins;Regulation;Research;Role;Scientist;SMARCA4 gene;Structure;SWI/SNF Family Complex;Testing;Therapeutic Intervention;therapeutic target;Tissues;Training;transcriptome sequencing;Transferase;Variant

PROJECT_TITLE: Elucidating the Functional Role of Post-translational Aminoacylation in Chromatin Regulation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F08-M(20)L]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Duchenne/ Becker Muscular Dystrophy;Genetics;Heart Disease;Muscular Dystrophy;Pediatric;Pediatric Cardiomyopathy;Rare Diseases

ORG_CITY: RICHMOND

ORG_DEPT: PEDIATRICS

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

PHR: PROJECT NARRATIVE Cardiovascular disease, characterized by heart rhythm problems and heart failure due to a process called cardiac fibrosis, is the main cause of death for young people with Duchenne Muscular Dystrophy (DMD). While there are currently no curative therapies and the mechanisms of heart disease in DMD remain poorly understood, we have identified that a protein called pannexin 1 (Px1) may play an important role in the development of DMD heart disease. This proposal seeks to understand the molecular mechanisms by which Px1 leads to fibrosis and abnormal rhythms in DMD, with a goal of discovering targeted therapeutic strategies that can preserve cardiovascular health and delay or prevent death from heart disease in this population.

PI_NAMEs: RAUCCI, FRANK J (contact)

PROGRAM_OFFICER_NAME: CHEON, YEWON

PROJECT_TERMS: 18 year old;Abbreviations;Ablation;Age;Apoptosis;Apoptotic;Arrhythmia;Biology;boys;Ca(2+)-Transporting ATPase;Calcium;Cardiac;Cardiac Electrophysiologic Techniques;Cardiac Myocytes;cardioprotection;Cardiovascular Diseases;cardiovascular health;Cause of Death;Cell Membrane Permeability;cell motility;Cell Nucleus;cell type;Cells;Cessation of life;Childhood;Coculture Techniques;Complex;coronary fibrosis;curative treatments;Cytoplasm;Data;Dedications;Defect;Development;Diagnosis;Dilated Cardiomyopathy;Disease;Duchenne cardiomyopathy;Duchenne muscular dystrophy;Dystrophin;endoplasm;experimental study;extracellular;Fibroblasts;Fibrosis;Foundations;Functional disorder;Funding;Gene Expression;Generations;Genes;Genetic;genetic approach;Goals;Heart Diseases;Heart failure;heart function;heart rhythm;Histopathology;Home;human induced pluripotent stem cells;Hypoxia;improved;in vivo;Inflammasome;Inflammation;Inflammatory;inflammatory modulation;Investigation;Ions;Isoproterenol;Knock-out;Link;marenostrin;Measures;Mediator;Mentorship;migration;Modality;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;Muscle Cells;Muscle Weakness;Muscular Dystrophies;Myocardial dysfunction;new therapeutic target;novel;Pathologic;Pathway interactions;Patients;Persons;pharmacologic;Phenotype;Physicians;Play;Population;preservation;prevent;Primary Myocardial Diseases;Process;programs;Proteins;Proton-Translocating ATPases;Purinoceptor;recruit;Regulation;Research;Research Personnel;Risk;Role;Ryanodine Receptor Calcium Release Channel;Sarcoplasmic Reticulum;Scientist;Signal Pathway;Signal Transduction;Skeletal Muscle;skills;small molecule;Stimulus;Stretching;Structure;Supportive care;Symptoms;targeted treatment;Testing;Time;Training Programs;Transgenic Mice;Transgenic Organisms;translational study;ventilation;Ventricular;Ventricular Arrhythmia

PROJECT_TITLE: Targeting Pannexin 1 as a Novel Mechanism for Arrhythmia and Fibrosis in Duchenne Cardiomyopathy

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(OA)]


NIH_SPENDING_CATS: Cardiovascular;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Human Genome;Regenerative Medicine

ORG_CITY: PITTSBURGH

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: The objective of this proposal is to delineate the cellular, molecular and genetic mechanisms of heart regeneration. Specifically, a focus on understanding how the zebrafish adult cardiomyocyte is activated upon injury to dedifferentiate and proliferate. The findings from these studies will identify new molecular pathways and factors to enhance repair and regeneration after myocardial infarction to address a societal health burden.

PI_NAMEs: TSANG, MICHAEL WAIKOK (contact)

PROJECT_TERMS: Acceleration;Address;Adult;Amputation;Apical;Apoptosis;aurora B kinase;Automobile Driving;candidate identification;Cardiac;Cardiac Myocytes;cardiac regeneration;cardiac repair;Cause of Death;cdc Genes;Cell Cycle;cell injury;Cells;Centromere;Cessation of life;Cicatrix;coronary vasculature;Coronary Vessels;cyclin B3;Cytokinesis;Endocardium;Endowment;Epicardium;Event;Excision;Failure;forkhead protein;FOXM1 gene;G2/M Transition;Gene Expression;Genes;Genetic;Goals;Health;Heart;Heart Diseases;heart function;Heart Injuries;Heterogeneity;In Situ;Infarction;injured;Injury;loss of function;M cell;Metabolic;Mitosis;Modeling;Molecular;mutant;Mutation;Myocardial;Myocardial Infarction;Myocardial Ischemia;Natural regeneration;Necrosis;novel strategies;novel therapeutics;Pathway interactions;Population;premature;prevent;Process;Proliferating;Proteins;Recording of previous events;Regenerative response;repaired;Resected;response;response to injury;Role;single-cell RNA sequencing;Societies;Testing;Tissues;Transcription Coactivator;transcriptome;transcriptome sequencing;transcriptomic profiling;ubiquitin-protein ligase;Ventricular;Zebrafish

PROJECT_TITLE: Understanding the molecular mechanism of cardiomyocyte dedifferentiation and proliferation during regeneration

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CVRS-R(02)]


NIH_SPENDING_CATS: Asthma;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Lung;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: SAN FRANCISCO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE We will identify genomic pathways that are epigenetically altered by clinical asthma risk factors that underlie health disparities in asthma subtypes and other complex diseases. Our team will study a unique cohort of minority children, who have existing demographic, clinical and socio-environmental and genetic data. We will compare children at the extremes of asthma prevalence and mortality: high risk Puerto Rican and African American children, and low risk Mexican American children.

PI_NAMEs: BORRELL, LUISA N;ZAITLEN, NOAH A;ZIV, ELAD  (contact)

PROGRAM_OFFICER_NAME: GAN, WEINIU

PROJECT_TERMS: Accounting;Address;Admixture;Affect;African American;African American population;Air Pollution;Algorithms;Allergic Disease;American;Asthma;Biological Markers;Biomedical Research;Bronchodilator Agents;cell type;Child;Chronic Disease;Clinical;clinical effect;clinical epidemiology;Clinical Research;clinical risk;clinical subtypes;cohort;Collaborations;Communities;Complex;Cytosine;Data;Data Set;Death Rate;diagnostic criteria;Disease;disorder subtype;Disparity;DNA Methylation;DNA Sequence;Environment;Environmental Epidemiology;Environmental Risk Factor;eosinophil;Epidemiology;epigenetic marker;Epigenetic Process;epigenetic variation;epigenomics;ethnic disparity;ethnic identity;ethnic minority;Ethnic Origin;Ethnic Population;Exposure to;Extrinsic asthma;Family history of;functional genomics;Funding;Genes;Genetic;genetic risk factor;genome-wide;genomic data;Genomics;Genotype;Goals;Guanine;health disparity;Heterogeneity;high risk;Hispanic;IgE;Immune response;improved;Incidence;Individual;inorganic phosphate;Intervention;Latino;Leukocytes;Life;Measures;Mediating;Mediation;Methylation;methylation pattern;Mexican;Mexican Americans;minority children;Morbidity - disease rate;mortality;neutrophil;novel;Obesity;Outcome;Participant;Pathway interactions;Patient Selection;Peripheral;Pharmaceutical Preparations;Phenotype;Population;power analysis;Prevalence;profiles in patients;programs;Puerto Rican;Race;racial disparity;racial minority;racial population;Recording of previous events;Research;Respiratory Disease;Respiratory Tract Infections;response;Risk;Risk Factors;RNA;RNA Sequences;Science;Serum;Site;skin prick test;Social Environment;social epidemiology;social factors;Spirometry;Statistical Methods;Testing;therapeutic target;Tobacco smoke;United States;Variant;whole genome;Work

PROJECT_TITLE: Epigenomics of asthma risk factors and clinical subtypes in minority children

STUDY_SECTION: IRAP

STUDY_SECTION_NAME: Infectious Diseases, Reproductive Health, Asthma and Pulmonary Conditions Study Section[IRAP]


ADMINISTERING_IC: NR

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Chronic Pain;Clinical Research;Digestive Diseases;Microbiome;Pain Research;Pediatric;Precision Medicine

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: PROJECT NARRATIVE Abdominal pain-related functional gastrointestinal disorders affect 10-20% of children and adults worldwide exerting a tremendous economic, social, and emotional burden. There is a critical need to understand what factors contribute to pain in these disorders so that effective management and treatment strategies can be designed. The results of this proposal will provide insight into the factors responsible for abdominal pain symptoms to allow better patient-specific treatment.

PI_NAMEs: SAVIDGE, TOR C. (contact)

PROGRAM_OFFICER_NAME: TYUS, NADRA

PROJECT_TERMS: 16S ribosomal RNA sequencing;Abdomen;Abdominal Pain;Adult;Affect;Bayesian Modeling;Behavioral;Bioinformatics;Biological Markers;Caring;Characteristics;Child;Childhood;Clinical Research;Data;Databases;design;Diagnosis;diaries;Diet therapy;Dietary Factors;Disabling;Disease;Distress;dysbiosis;Economics;Emotional;enteric infection;Evaluation;Feces;Functional disorder;Functional Gastrointestinal Disorders;Funding;Gastroenterologist;Genes;Goals;gut dysbiosis;gut inflammation;gut microbiome;Impairment;improved;Individual;individual patient;individualized medicine;Inflammation;innovation;insight;Irritable Bowel Syndrome;Link;lipidomics;Mediating;Metabolic Pathway;metabolomics;Metagenomics;metaproteomics;Methodology;microbial;microbial community;microbiome;microbiome research;Modeling;multidisciplinary;Neuroimmune;novel;Nurse Practitioners;Oranges;Outcome Measure;Pain;pain symptom;Pathogenesis;Pathway interactions;Patients;Pattern;Pediatric Hospitals;Permeability;Pharmacotherapy;Phenotype;Physiology;Precision Medicine Initiative;Productivity;prospective;psychosocial;Public Health;Publishing;Quality of life;Questionnaires;Recommendation;Recurrence;Recurrent pain;Reporting;Research;Resolution;Schools;Shotguns;social;specific biomarkers;stool sample;supervised learning;symptom science;Symptoms;Technology;Texas;Therapeutic;therapeutic target;treatment strategy;United States National Institutes of Health;Virulence Factors;whole genome;Whole-Genome Shotgun Sequencing;Work

PROJECT_TITLE: PATHWAYS TO NEW BIOMARKERS IN RECURRENT ABDOMINAL PAIN IN CHILDREN

STUDY_SECTION: NRCS

STUDY_SECTION_NAME: Nursing and Related Clinical Sciences Study Section[NRCS]