PI_NAMEs: STORZ, GISELA  (contact)

PROJECT_TERMS: 3' Untranslated Regions;5' Untranslated Regions;6S RNA;Acetyltransferase;Affect;Amino Acids;Bacteria;Bacterial Physiology;Bacteriophages;Base Pairing;Binding;Binding Sites;Biochemical;biological adaptation to stress;Biological Assay;Carbon;cell motility;Cells;Co-Immunoprecipitations;Code;Collaborations;Complex;Consumption;deep sequencing;Defect;Detection;DNA-Directed RNA Polymerase;Escherichia coli;Evolution;Flagella;Flagellin;Focus Groups;Follow-Up Studies;Galactose;Gene Expression;gene repression;Genes;genetic approach;genetic regulatory protein;genome annotation;Glucose;Glutamate-Ammonia Ligase;Growth;Human;insight;Intercistronic Region;interest;KH Domain;Learning;Manganese;Maps;Mediating;Messenger RNA;Metabolism;Molecular Chaperones;Molecular Conformation;Mutation;Nitrogen;Nucleotides;Organism;overexpression;Oxidation-Reduction;Oxidative Stress;Pathway interactions;Phenotype;Physiological;Play;prevent;promoter;Proteins;Regulation;Regulon;Repression;response;Ribosomes;RNA;RNA Binding;RNA Recognition Motif;RNA-Binding Proteins;Role;Sigma Factor;small molecule;Small RNA;Source;Spottings;Structure;synthetic construct;Terminator Codon;Tertiary Protein Structure;Transcript;Translational Repression;Translations;Untranslated Regions;Untranslated RNA;Work

PROJECT_TITLE: Small Regulatory RNAs


ACTIVITY: ZIA

ADMINISTERING_IC: HD

ARRA_FUNDED: N

FUNDING_MECHANISM: INTRAMURAL RESEARCH

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Cancer;Genetics;Hematology;Immunotherapy;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

PI_NAMEs: LOVE, PAUL E (contact)

PROJECT_TERMS: Acute T Cell Leukemia;Affinity;antigen-specific T cells;Area;Autoimmune Diseases;Binding;Biochemical;Blood Cells;Blood Platelets;cancer immunotherapy;cancer therapy;Catalytic Domain;CD3 Antigens;CD3E gene;Cell Cycle;Cell Differentiation process;Cell Maintenance;Cells;Childhood Leukemia;Compensation;Complex;conditional knockout;Data;Development;Diagnosis;Discrimination;dityrosine;DNA Binding;Ensure;Enterobacteria phage P1 Cre recombinase;Erythrocytes;Erythroid;Erythropoiesis;experimental study;Family member;Feedback;Gene Silencing;Gene Targeting;Generations;Genes;Genetic Transcription;Germ Lines;Hematopoiesis;hematopoietic stem cell self-renewal;Hematopoietic stem cells;Hematopoietic System;Human;human stem cells;Immune checkpoint inhibitor;Immunotherapy;Individual;inhibitor;Integral Membrane Protein;interest;Intestines;Investigation;ITAM;Knock-in;Knockout Mice;Knowledge;Laboratories;Libraries;Life;Ligands;LIM Domain;Lymphocyte;Maintenance;Malignant Neoplasms;Mature T-Lymphocyte;Mediating;Modeling;mouse model;Mus;mutant;Mutant Strains Mice;Myeloid Cells;neoplastic cell;notch protein;novel;Pathway interactions;Peptides;Phenotype;Phosphorylation;progenitor;programs;Proliferating;Protein Binding Domain;Protein Family;Protein Tyrosine Kinase;Protein Tyrosine Phosphatase;Proteins;prototype;PTPN6 gene;receptor;Receptor Signaling;reconstitution;recruit;Research;response;Role;screening;self-renewal;Signal Transduction;Signaling Molecule;SKP Cullin F-Box Protein Ligases;stemness;Surface;System;T cell regulation;T-Cell Activation;T-Cell Development;T-Cell Receptor;T-Lymphocyte;Testing;text searching;therapeutic target;thymocyte;Thymocyte Development;Thymocyte Selection;Thymus Gland;transcriptome sequencing;Transgenes;Transgenic Organisms;tumor;tumorigenesis;virtual;Work

PROJECT_TITLE: Genes and signals controlling mammalian hematopoiesis.


NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Congenital Structural Anomalies;Genetics;Human Genome;Pediatric;Rare Diseases

ORG_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

PI_NAMEs: PFEIFER, KARL ERIC (contact)

PROJECT_TERMS: 11p15.5;3-Dimensional;Address;Adult;Affect;Alleles;autosome;Beckwith-Wiedemann Syndrome;Behavior;Binding;Biochemical;Biological Models;Birth;Bruck-de Lange syndrome;cancer type;Cardiomyopathies;Cell Cycle Regulation;Cell Differentiation process;cell growth;Cell Nucleus;Cell Physiology;Cells;Cellular Stress;Chromatin Structure;Chromosome 7;Chromosomes;clinically significant;cohesin;Compensation;Complex;coronary fibrosis;CRISPR/Cas technology;Curiosities;Defect;Deletion Mutagenesis;Development;developmental disease;Developmental Process;Disease;Distal;DNA;DNA Modification Process;Elements;Endothelial Cells;Endothelium;Epigenetic Process;epigenome;Equilibrium;Excision;Exercise;Fathers;Fibrosis;Gene Cluster;Gene Expression;Gene Expression Profile;gene function;Gene Mutation;Genes;Genetic;genetic analysis;Genetic Enhancer Element;Genetic Transcription;Genome;Genomics;Germ Cells;Goals;Growth;H19 gene;H19 RNA;Health;Heart;heart function;Human;human disease;Hypermethylation;Hypertrophy;IGF2 gene;imprint;in vitro Model;Inherited;Injury;Insertional Mutagenesis;loss of function;Malignant Childhood Neoplasm;Malignant Neoplasms;Mammals;MAP Kinase Gene;Mediating;Mesenchymal;Messenger RNA;Methylation;MicroRNAs;Modeling;Molecular;Mothers;mouse model;Mouse Strains;Mus;Muscle;Muscle Cells;Muscle Development;muscle regeneration;Mutate;Mutation;Myocardial dysfunction;Nephroblastoma;novel;overexpression;Parents;Pathologic;Pathway interactions;Patients;Pattern;Phenotype;Physiological;Placenta;Play;postnatal;Predisposition;premature;prevent;Process;programs;promoter;protein complex;Proteins;Regulation;Research;RNA;RNA Precursors;Role;sarcopenia;senescence;Silver-Russell syndrome;Skeletal Muscle;Stress;Tissues;TP53 gene;transcription factor;Transcriptional Silencer Elements;transcriptome;Translations;Untranslated RNA

PROJECT_TITLE: Regulated expression and developmental functions of the H19 long noncoding RNA


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Dental, Oral, and Craniofacial Disease;Neurosciences;Nutrition

PI_NAMEs: STOPFER, MARK A (contact)

PROJECT_TERMS: Action Potentials;Anatomy;Animals;Area;awake;Behavior;Behavioral;Brain;Cells;Code;Complex;Electrophysiology (science);Environment;excitatory neuron;experimental study;Genetic;Goals;inhibitory neuron;Insecta;Lobe;Memory;Methods;Mushroom Bodies;Nervous System;Nervous System Physiology;neural;neural circuit;Neurons;Odors;olfactory bulb;Olfactory Pathways;Pattern;piriform cortex;Population;Process;receptor;Rest;Sensory;sensory stimulus;Smell Perception;Structure;success;Taste Perception;taste system;Vertebrates

PROJECT_TITLE: Sensory Coding by Ensembles of Neurons.


NIH_SPENDING_CATS: Genetics

PROJECT_TERMS: Aerobic;Affinity;alpha helix;Amino Acids;anti-toxin;Antibiotics;ATP phosphohydrolase;Bacteria;Bacteriophages;Base Pairing;Binding;Binding Sites;Biochemical;Biological Assay;C-terminal;Cells;Chromosomes;Conserved Sequence;Defect;Development;Dimerization;Drug Efflux;efflux pump;Enzymes;Escherichia coli;Eukaryotic Cell;experimental study;Exposure to;Galactose;Genes;genetic approach;Genetic Recombination;genetic regulatory protein;Genetic Transcription;Genome;genome annotation;genome wide screen;genome-wide;Glucose;Glycerol;Glycerol-3-Phosphate Dehydrogenase;Growth;Human;Initiator Codon;insight;Intercistronic Region;interest;Kinetics;Length;Magnesium;Mammalian Cell;Manganese;member;Membrane;Membrane Proteins;Modeling;Molecular Conformation;mutant;novel;nuclease;Nucleotides;Open Reading Frames;Organism;overexpression;Oxidants;Oxidoreductase;Pathway interactions;Peptides;Pharmaceutical Preparations;Phenotype;Plasmids;Production;Protein Biosynthesis;Proteins;Regulation;Repression;response;ribosome profiling;Ribosomes;RNA;Role;Signal Transduction;Site;small molecule;Small RNA;Spottings;Stress;Structure;System;Terminator Codon;Testing;Toxin;transcription factor;Translating;Translation Initiation;Translations;Untranslated RNA;Variant;Western Blotting;Work

PROJECT_TITLE: Small Regulatory Proteins


NIH_SPENDING_CATS: Genetics;Neurosciences

PI_NAMEs: SERPE, MIHAELA  (contact)

PROJECT_TERMS: Activins;Adult;Algorithms;Antibodies;Atlases;Autocrine Communication;Behavior;Behavioral;Binding;Biochemical;Biological;Biological Models;BMP7 gene;BMPR2 gene;bone morphogenetic protein receptors;Bone Morphogenetic Proteins;Cell Communication;Cell Fate Control;cell fate specification;cell type;Cells;Complex;Coupling;Data Set;Development;Diameter;Drosophila genus;Drosophila melanogaster;Electrophysiology (science);Environment;Eukaryota;Evolution;Feedback;Fluorescence-Activated Cell Sorting;fly;Future;Generations;Genes;Genetic;Genetic Models;Genetic Transcription;Glutamate Receptor;Glutamates;Goals;Growth;Growth Factor;Homeostasis;in vivo;Individual;insight;Interneurons;LIMK1 gene;Link;Membrane;Metabolic Pathway;Modality;Modeling;Modification;Molecular;Molecular Conformation;Monitor;morphogens;Morphology;Motor;Motor Neurons;Muscle;mutant;Mutation;nanocolumn;Natural regeneration;Nerve;Nervous System;neural;neuroblast;neurogenesis;Neuroglia;Neuromuscular Junction;neuronal cell body;Neurons;neurotransmission;Neurotransmitter Receptor;neurotransmitter release;Neurotransmitters;newborn neuron;novel;Optics;Pathway interactions;Phosphorylation;Phosphotransferases;Physiological;Physiology;Population;postsynaptic;presynaptic;presynaptic neurons;Presynaptic Terminals;Process;programs;receptor;recruit;Regulation;repaired;Reproducibility;Research;Resolution;Resources;response;Role;sensor;Shapes;Signal Pathway;Signal Transduction;Signaling Molecule;Signaling Protein;single-cell RNA sequencing;Site;Spinal Cord;Synapses;System;Thinness;Time;Tissues;Transcript;Transforming Growth Factor beta;Vertebrates;Wit;Work

PROJECT_TITLE: Modulation of TGF-beta signaling


NIH_SPENDING_CATS: Biotechnology;Genetics;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza;Rare Diseases

PI_NAMEs: MACHNER, MATTHIAS  (contact)

PROJECT_TERMS: Acanthamoeba;Acanthamoeba castellanii;aerosolized;Affect;Algorithms;Alveolar Macrophages;Amoeba genus;Bacteria;Bacterial Genes;Bioinformatics;Biology;Bypass;cell growth;Cell membrane;Cells;Chromosome Deletion;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Collection;contaminated water;Contracts;CRISPR interference;Cutaneous Melanoma;Dangerousness;Data;Defect;design;Development;Disease;Disease Outbreaks;Drug Targeting;Economic Burden;Elderly;Event;Exposure to;extracellular;Foundations;Fresh Water;Funding;Gene Combinations;Gene Family;Gene Silencing;Genes;Genetic;Goals;Growth;Guanosine Triphosphate Phosphohydrolases;Habitats;Health;Human;Immune;Immune system;improved;Individual;Infant;Infection;Infection prevention;Inhalation;Investigation;Knowledge;Legionella;Legionella pneumophila;Legionnaires' Disease;Libraries;Life;Lung;lung pathogen;Macrophage;Malignant Neoplasms;Mammalian Cell;microbial;Mitogen-Activated Protein Kinases;Molecular;Monitor;Mutate;Mutation;National Institute of Allergy and Infectious Disease;novel;novel therapeutics;Oligonucleotides;Oncoproteins;Output;pathogen;Pathogenesis;pathogenic bacteria;pathogenic microbe;Pathway interactions;Personal Satisfaction;Persons;Phenotype;Plasmids;Pneumonia;prevent;Process;Proliferating;protein function;Protein Isoforms;Protein translocation;Proteins;Proteome;Randomized;ras Proteins;recruit;Research;Research Personnel;Respiratory Tract Infections;Risk;Role;self assembly;sequencing platform;Signal Pathway;Signal Transduction;Source;therapeutic development;Time;tool;Transmembrane Domain;transmission process;Type IV Secretion System Pathway;Vacuole;Virulence;Virulence Factors;Water;Wisconsin

PROJECT_TITLE: Virulence strategies of the lung pathogen Legionella pneumophila


NIH_SPENDING_CATS: Conditions Affecting the Embryonic and Fetal Periods;Contraception/Reproduction;Dietary Supplements;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Maternal Morbidity and Mortality;Nutrition;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Racial and Ethnic Minority Health Research;Women's Health Research

PI_NAMEs: GREWAL, JAGTESHWAR  (contact)

PROJECT_TERMS: Address;adverse pregnancy outcome;African American;Age Years;Asian;Birth Weight;Conceptions;Data;Data Collection;Dietary History;Dietary intake;dietary supplements;Enrollment;ethnic diversity;Ethnic Origin;Ethnic Population;Fetal Growth;Fetus;First Pregnancy Trimester;Food;Frequencies;Gestational Diabetes;Goals;good diet;health of the mother;Herbal supplement;Heterogeneity;Hispanic;Hour;in utero;individual variation;Intake;Lactation;Literature;Measurement;Micronutrients;mother nutrition;National Cancer Institute;National Institute of Child Health and Human Development;Not Hispanic or Latino;Nutrient;nutrition;Nutrition Monitoring;Observational Study;Online Systems;Outcome;Participant;Pattern;Population;population based;Pre-Eclampsia;Pregnancy;Pregnancy Complications;Pregnancy Outcome;pregnant;Premature Birth;prospective;Prospective Studies;Questionnaires;Race;racial diversity;racial population;recruit;Research;Sampling;Second Pregnancy Trimester;Self Administration;socioeconomics;Surveys;Third Pregnancy Trimester;United States;Woman

PROJECT_TITLE: Nutrition and dietary supplements intake during pregnancy and fetal growth


NIH_SPENDING_CATS: Neurosciences

PROJECT_TERMS: Acids;Affinity;Alternative Splicing;Amino Acids;Animal Model;Animals;Architecture;aspartate receptor;autism spectrum disorder;Axon;Binding;Biological Models;biophysical properties;Case Study;Cells;Cellular biology;Characteristics;Chimera organism;Complex;Crustacea;Cytoplasmic Tail;Dedications;Defect;Detection;Development;Docking;Drosophila genus;Electrophysiology (science);Elements;Embryo;Epitopes;Excitatory Synapse;extracellular;Extracellular Protein;Family;fly;Genetic;genetic manipulation;Glutamate Receptor;Glutamates;Goals;Homeostasis;Human Pathology;In Vitro;in vivo;Individual;Insecta;intercellular communication;Intrabody;Investigation;kainate;Kainic Acid Receptors;Learning;Length;Ligand Binding;Mediating;Membrane;Memory impairment;Methodology;migration;Modeling;Molecular;Motor Neurons;Muscle;N-Methylaspartate;nanobodies;Neuromuscular Junction;Neurons;neurotransmission;neurotransmitter release;Optics;Phosphorylation;Physiological;Physiology;postsynaptic;presynaptic;Presynaptic Receptors;Process;programs;Property;protein complex;Protein Family;Protein Isoforms;Proteins;rational design;receptor;receptor function;reconstitution;recruit;Reproducibility;Research;response;Role;Signal Transduction;Site;Structure;Surface;Synapses;Synaptic Receptors;synaptogenesis;System;Testing;Tissues;tool;trafficking;Transmembrane Domain;ultra high resolution;Variant;Vertebrates;Vesicle;Xenopus oocyte

PROJECT_TITLE: Mechanisms of synapse development


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Nutrition;Obesity;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Social Determinants of Health;Women's Health Research

PI_NAMEs: NANSEL, TONJA  (contact)

PROJECT_TERMS: Address;Age;Behavior Control;Body mass index;Body Weight;Body Weight Changes;Competence;critical developmental period;Data;Diet;Dietary intake;early pregnancy;Eating;Eating Behavior;Education;Enrollment;Ethnic Population;Family;Fatty acid glycerol esters;feeding;Feeding behaviors;Focus Groups;Food;food environment;Frequencies;Fruit;fruits and vegetables;Functional Magnetic Resonance Imaging;General Population;gestational weight gain;Goals;Guidelines;Health behavior;hedonic;Home;Hyperphagia;improved;Income;Individual;Infant;Informal Social Control;Institute of Medicine (U.S.);Intake;Intervention;Investigation;Juice;Laboratories;Life;Maternal and Child Health;Medical Records;modifiable risk;mother nutrition;neural;neurobehavioral;Nutrient;Nutrition management;Obesity;obesity in pregnancy;obesogenic;observational cohort study;Outcome;Overweight;Participant;Patient Self-Report;perceived stress;population based;Postpartum Period;postpartum weight;Pregnancy;Pregnant Women;Process;Prospective, cohort study;Psychosocial Factor;Public Health;racial population;Recommendation;Reporting;response;Rewards;Risk Factors;Role;Sampling;Self-control as a personality trait;sleep health;socioeconomic disparity;success;sweetened beverage;Weight;Weight Gain;Weight maintenance regimen;Work

PROJECT_TITLE: Diet, Weight Change, and Obesity in Pregnancy / Pregnancy Eating Attributes (PEAS)


PI_NAMEs: DASSO, MARY C. (contact)

PROJECT_TERMS: Acute;Amyotrophic Lateral Sclerosis;Auxins;Binding;Biological;Biological Models;Cell Cycle;cell growth;Cell Line;Cell Nucleus;Cell Physiology;Cells;Chromatin;chromatin remodeling;Chromosome Segregation;Complex;CRISPR/Cas technology;Cytoplasm;Cytoplasmic Filaments;Development;Developmental Process;Enzymes;experimental study;Filament;fly;Gene Expression;Genes;genetic regulatory protein;Genetic Transcription;Genome;Goals;GTPase-Activating Proteins;Guanine Nucleotide Exchange Factors;Guanosine Triphosphate;Housekeeping;Human;human disease;Human Genome;Individual;Interphase;Interphase Cell;Kidney Diseases;Kinetochores;Maintenance;Mediating;member;Mitosis;Mitotic;Mitotic Chromosome;Mitotic spindle;Modification;Molecular;mRNA Export;Mutation;MXD1 gene;Neurodegenerative Disorders;novel;Nuclear;Nuclear Envelope;Nuclear Export;Nuclear Import;Nuclear Pore Complex;nuclear pore complex protein 96;nuclear pore complex protein p107;Nuclear Pore Complex Proteins;nucleocytoplasmic transport;Nucleoplasm;Organism;Pathology;Phenotype;Play;postmitotic;Process;Proteins;receptor;recruit;Regulation;response;RNA;Role;Running;scaffold;Spermatogenesis;Steroid-resistant idiopathic nephrotic syndrome;SUMO1 gene;System;Testis;Tissues;trafficking;transcriptomics;Work

PROJECT_TITLE: Mitotic roles of the Nuclear Transport Machinery


NIH_SPENDING_CATS: Brain Disorders;Genetics;Human Genome;Neurosciences;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

PI_NAMEs: PETROS, TIMOTHY  (contact)

PROJECT_TERMS: Adult;ATAC-seq;Ataxia Telangiectasia;autism spectrum disorder;Axon;Behavior;Biological Assay;blastocyst;Brain;Brain Diseases;Brain region;Candidate Disease Gene;candidate identification;Cell Cycle;Cell Nucleus;Cell Proliferation;Cell Transplantation;Cells;Chromatin;Cleavage Under Targets and Release Using Nuclease;Collaborations;Complex;Congenital cerebral hernia;CRISPR/Cas technology;Development;disease model;Electrophysiology (science);Embryo;Embryonic Development;Enhancers;Environment;Epigenetic Process;epigenetic regulation;Epilepsy;Equilibrium;experimental study;EZH2 gene;follow-up;frontier;Gene Activation;Gene Expression;Gene Expression Profile;Gene Expression Regulation;gene repression;Genes;Genetic;Genetic Transcription;genomic locus;Goals;Guide RNA;Hi-C;histone methylation;Homologous Gene;Human;human disease;Hypothalamic structure;In Vitro;in vivo;insight;interest;Interneuron function;Interneurons;Knockout Mice;Libraries;Ligands;Link;Logic;loss of function;Lysine;Manuscripts;Medial;Mediating;Methyltransferase;Midbrain structure;Modification;Molecular;Morphology;Mouse Embryonic Stem Cells;multiple omics;Mus;Mutation;Nervous System;neurochemistry;neurodevelopment;Neurodevelopmental Disorder;neurogenesis;Neurons;Neurosciences;Parvalbumins;Phenotype;Play;Polycomb;Population;postmitotic;precursor cell;Predisposition;Primates;Procedures;Production;progenitor;promoter;Property;Prosencephalon;Protocols documentation;Publications;Publishing;Reporting;Repression;Resistance;Role;Schizophrenia;Seizures;Series;Severities;Signal Transduction;single cell ATAC-seq;single cell sequencing;single-cell RNA sequencing;Site;Somatostatin;Source;Spinal Cord;Suspensions;Techniques;Tissues;tool;transcriptome;transcriptome sequencing;Transgenic Mice;Up-Regulation;Weaver Syndrome;Weight Gain;Writing

PROJECT_TITLE: Genetic and Epigenetic Mechanisms Regulating Fate and Maturation of Forebrain Inhibitory Interneurons


PI_NAMEs: BASSER, PETER J. (contact)

PROJECT_TERMS: absorption;Address;Affect;Age;aggrecan;Aging;Agreement;Architecture;Behavior;Binding;Biochemical;Biological;Biological Models;Biological Process;Biomimetics;biophysical properties;Brain;brain tissue;Carbomer-940;Cartilage;cartilage degradation;Cartilage Diseases;Cell Differentiation process;Cell Proliferation;Cells;Characteristics;Charge;chemical property;Chemicals;Chondroitin Sulfates;Collagen;Complex;crosslink;Data;Degenerative polyarthritis;density;Development;Disease;Early Diagnosis;Elasticity;Ensure;Environment;Equilibrium;Exhibits;experimental study;Extracellular Matrix;Filler;flexibility;Gel;Growth Factor;Human;Hyaluronic Acid;Hydration status;Hydrogels;imaging modality;Immobilization;In Vitro;in vivo;instrument;joint mobilization;Joints;Knowledge;Knowledge acquisition;Length;Liquid substance;macromolecule;Magnetic Resonance Imaging;Maps;Measurement;Measures;mechanical behavior;mechanical properties;Mechanics;Methods;Modeling;Modulus;Molecular Conformation;molecular dynamics;Motion;nanometer;Nature;novel;novel strategies;Osmosis;Osmotic Pressure;particle;Pathologic;Physiological;Pilot Projects;Polymers;Polysaccharides;Polyvinyl Alcohol;pressure;Process;Property;Proteins;Proteoglycan;Protons;Relaxation;Research Design;Resistance;Resolution;response;Role;Rubber;Sampling;scaffold;Scanning;Scanning Probe Microscopes;self assembly;Specimen;spectroscopic imaging;Stress;Structure;Supporting Cell;Swelling;System;Techniques;theories;Time;tissue mapping;Tissue Sample;Tissues;Transport Process;Trauma;vapor;Variant;Vertebral column;virtual;viscoelasticity;Visualization;Water;Weight-Bearing state

PROJECT_TITLE: Measuring and Mapping Functional Properties of Extracellular Matrix (ECM)


NIH_SPENDING_CATS: Bioengineering;Biotechnology

PROJECT_TERMS: Address;Affect;aggrecan;Anions;Architecture;Area;Behavior;bench to bedside;Binding;Biological Models;Biological Process;biological systems;Biological Transport;Biomimetics;Biopolymers;Calcium ion;Calibration;Carbomer-940;Cartilage;Cations;Cells;Charge;Chemicals;Chemistry;Chondroitin Sulfates;Collaborations;Complex;crosslink;density;design;Development;Diffusion;Disease;Divalent Cations;DNA;dynamic system;Elasticity;Electrostatics;Elements;Environment;environmental change;Exhibits;experimental study;flexibility;Foundations;Gastrointestinal tract structure;Gel;Goals;Hyaluronic Acid;Hydration status;Hydrogels;Hydrogen Bonding;hydrophilicity;Hydrophobicity;Image;insight;interest;Ionic Strengths;Ions;Israel;Knowledge;Length;light scattering;Lung;macromolecule;Magnetic Resonance Imaging;mathematical model;Measurement;mechanical properties;Mechanics;Methodology;Methods;model design;Modeling;Modulus;Molecular;Molecular Conformation;molecular dynamics;molecular mass;Mucins;Muscle;Mussels;Nature;Nerve;Neutrons;novel;novel diagnostics;Organism;Osmosis;Osmotic Pressure;Phase;Phase Transition;physical chemical interaction;Physical condensation;physical property;Physics;Physiological;Play;polyanion;Polymers;Postdoctoral Fellow;Precipitation;predictive modeling;pressure;prevent;Procedures;Process;professor;Property;Proteoglycan;quality assurance;Quality Control;Relaxation;reproductive tract;Resistance;Resolution;response;Roentgen Rays;Role;Science;Series;sodium ion;Structure;Swelling;System;Techniques;Temperature;Therapeutic;Thermodynamics;Time;Tissue Model;tissue phantom;tissue regeneration;Tissues;translational applications;Transport Process;Universities;van der Waals force;Vertebral column;viscoelasticity;Water

PROJECT_TITLE: Fundamental Studies and Applications of Tissue Sciences


PI_NAMEs: ROCHA, PEDRO  (contact)

PROJECT_TERMS: 3-Dimensional;Animals;Architecture;ATAC-seq;Biological Models;Biophysics;blastocyst;candidate identification;cell behavior;Cell Differentiation process;Cell division;Cell Lineage;Cell Nucleus;cell type;Cells;ChIP-seq;Chromatin Structure;Chromosomes;Code;CRISPR screen;Development;Disease;DNA;DNA Folding;Elements;Embryo;embryo tissue;Endoderm;Epiblast;Epigenetic Process;Eukaryotic Cell;experimental study;fascinate;Fertilization;Future;Gene Expression;Gene Expression Regulation;gene regulatory network;Genetic;Genetic Transcription;Genome;genome editing;genome-wide;Genomics;Goals;Health;Hi-C;high throughput technology;Histones;imaging approach;in vivo;interest;Mammals;meter;Modification;mouse development;mouse genome;Mus;Nuclear;Oocytes;Organism;Physical condensation;Placenta;Process;programs;Proteins;Regulation;Research;Signal Pathway;sperm cell;Structure;System;Techniques;Totipotent;Untranslated RNA;Yolk Sac;zygote

PROJECT_TITLE: Genome 3D organization as a determinant of cell-fate decisions


PI_NAMEs: BLITHE, DIANA  (contact)

PROJECT_TERMS: Aerosols;androgen sensitive;androgenic;Androgens;Biological Availability;Dose;drug candidate;Employee;Formulation;Gel;Goals;Hormonal;hormone therapy;Hour;hypothalamic pituitary axis;Implant;Injections;interest;invention;lead candidate;Legal patent;Male Contraceptive Agents;Methods;Modification;National Institute of Child Health and Human Development;Needles;new chemical entity;novel;Oral;Pharmaceutical Preparations;Process;Prodrugs;Production;Property;Publications;receptor binding;Reporting;Research Project Grants;Serum;sperm cell;Spermatogenesis;steroid hormone;Steroids;Testis;Testosterone;Transactivation

PROJECT_TITLE: Novel Substituted Steroid Hormones


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Childhood Obesity;Clinical Research;Nutrition;Obesity;Pediatric;Prevention

PROJECT_TERMS: 2 year old;7 year old;Advanced Development;Age;attentional bias;Authoritarianism;Body mass index;Characteristics;Child;Child Development;Childhood;cohort;Color;Consumption;COVID-19 pandemic;critical period;Cues;Data Collection;Desire for food;Development;Diet;Diet Habits;dietary;Dietary intake;early childhood;early life exposure;early pregnancy;Eating;Eating Behavior;eating in absence of hunger;Edible Plants;energy density;Environmental Risk Factor;Exposure to;Family;feeding;Food;food environment;Food Preferences;Future;gestational weight gain;Goals;Growth;Health;hedonic;high reward;Home;Image;Individual;infancy;Infant;Informal Social Control;Intake;Interruption;Intervention;Knowledge;Life;Nature;neurobehavioral;Nutritional;Obesity;obesity risk;parental influence;parental role;Persons;Postpartum Period;predicting response;Pregnancy;prenatal;Process;Psychological reinforcement;recruit;Research;response;reward circuitry;Rewards;Satiation;Self-control as a personality trait;Shapes;Testing;trait;Unhealthy Diet;Visit;visual tracking;Weight

PROJECT_TITLE: Sprouts: Development of Eating Behaviors in Early Childhood


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Basic Behavioral and Social Science;Batten Disease;Behavioral and Social Science;Brain Disorders;Congenital Structural Anomalies;Dementia;Genetics;Intellectual and Developmental Disabilities (IDD);Neurodegenerative;Neurosciences;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PI_NAMEs: PORTER, FORBES  (contact)

PROJECT_TERMS: 7-dehydrocholesterol;Adolescent;Adult;Affect;Age;autism symptoms;autosome;Basic Science;Behavioral;behavioral phenotyping;Belief;Biochemical Process;Biocompatible Materials;Biological;Biological Models;biomarker discovery;biomarker identification;biomarker validation;Blindness;Blood;boys;Brain;Cell Line;Cell Physiology;Cells;Cerebellar Diseases;Child;Childhood;Cholesterol;clinical care;Clinical Data;Clinical Protocols;Clinical Research;Clinical Sciences;CLN3 gene;Collaborations;Collection;congenital anomaly;Creatine;creatine transporter;Data;Databases;Dementia;Development;Developmental Process;Diagnostic tests;Disease;drug testing;Dysmorphology;Enrollment;Enzymes;Face;Fibroblasts;Fireflies;Foundations;Functional disorder;Funding;Gastrointestinal tract structure;Genes;Genetic;Genetic Diseases;Genitalia;Goals;Growth;Heart;Hereditary Disease;Human;Impaired cognition;Impairment;improved;In Vitro;in vivo;Inborn Errors of Metabolism;Incidence;Individual;induced pluripotent stem cell;Infant;insight;Investments;Kidney;Laboratories;Laboratory Research;Learning Difficulty;Limb structure;Link;Lipids;Lobule;Lung;Lysosomal Storage Diseases;malformation;Medical Research;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;Multipotent Stem Cells;Mus;mutant;Mutation;National Center for Advancing Translational Sciences;Natural History;Neimann-Pick's Disease Type C;Neonatal Screening;Neurodegenerative Disorders;Niemann-Pick Diseases;NPC1 gene;Obsessive compulsive behavior;Participant;Pathologic;Pathologic Processes;Pathology;Patient Care;Patients;pediatric patients;Phenotype;potential biomarker;Problem behavior;Process;prognostic value;progressive neurodegeneration;protein biomarkers;Proteins;Psyche structure;rare genetic disorder;Research;Sampling;Seizures;Smith-Lemli-Opitz Syndrome;Spielmeyer-Vogt Disease;Structural defect;Syndrome;synergism;Testing;Therapeutic;Therapeutic Agents;therapeutic evaluation;Therapeutic Intervention;transcriptomics;Translational Research;translational study;whole genome;Work;Zebrafish

PROJECT_TITLE: Basic and Translational Studies of Inborn Errors of Metabolism


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Batten Disease;Behavioral and Social Science;Biotechnology;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Congenital Structural Anomalies;Dementia;Genetics;Intellectual and Developmental Disabilities (IDD);Neurodegenerative;Neurosciences;Orphan Drug;Pediatric;Rare Diseases

PROJECT_TERMS: 7-dehydrocholesterol;Adolescent;Adult;Affect;Age;autism symptoms;autosome;Basic Science;Behavioral;behavioral phenotyping;Belief;Biochemical Process;Biocompatible Materials;Biological;Biological Markers;biomarker identification;Blindness;boys;Brain;Cell Physiology;Cerebellar Diseases;Child;Childhood;Cholesterol;clinical care;Clinical Data;clinical investigation;clinical outcome measures;Clinical Protocols;Clinical Research;Clinical Sciences;CLN3 gene;cohort;Collaborations;Collection;congenital anomaly;Country;Creatine;creatine transporter;Cyclodextrins;Cysteine;Dementia;Developmental Process;Dietary Cholesterol;Disease;Dysmorphology;efficacy evaluation;Enrollment;Enzymes;Face;Fireflies;Foundations;Functional disorder;Funding;Future;Gastrointestinal tract structure;Genes;Genetic;Genetic Diseases;Genitalia;Genomics;Goals;Growth;Heart;Hereditary Disease;Impaired cognition;Impairment;improved;Inborn Errors of Metabolism;Incidence;Individual;Infant;insight;Intravenous;Kidney;Laboratories;Learning Difficulty;Limb structure;Link;Lung;Lysosomal Storage Diseases;malformation;Medical Research;Molecular;Morbidity - disease rate;mortality;Mutation;National Center for Advancing Translational Sciences;Natural History;Neimann-Pick's Disease Type C;Neonatal Screening;Neurodegenerative Disorders;Niemann-Pick Diseases;NPC1 gene;Observational Study;Obsessive compulsive behavior;Participant;Pathologic;Patient Care;Patients;pediatric patients;Phenotype;Problem behavior;Process;progressive neurodegeneration;Proteins;Psyche structure;rare genetic disorder;Research;Safety;Seizures;Simvastatin;Smith-Lemli-Opitz Syndrome;Spielmeyer-Vogt Disease;Structural defect;Supplementation;Syndrome;synergism;Therapeutic;Therapeutic Intervention;Therapeutic Trials;Translational Research;Vorinostat;Work

PROJECT_TITLE: Clinical Investigations of Inborn Errors of Metabolism


NIH_SPENDING_CATS: Biotechnology;Emerging Infectious Diseases;Genetics;Infectious Diseases;Lyme Disease;Tickborne Diseases;Vector-Borne Diseases

PI_NAMEs: ADAMS, PHILIP  (contact)

PROJECT_TERMS: Attenuated;Bacteria;Bacterial Infections;Borrelia burgdorferi;Cell division;cell motility;Complex;Distant;Emerging Communicable Diseases;Environment;enzootic;Epsilonproteobacteria;Event;Filament;Firmicutes;Flagella;Future;gene conservation;gene discovery;Gene Expression;Gene Expression Regulation;Gene Order;Genes;Genetic;Goals;Homologous Gene;Immune response;immunogenic;Infection;Ixodes;kinetosome;Lyme Disease;Maps;Mediating;Modeling;Motility;Mus;novel;Open Reading Frames;Operon;Order Spirochaetales;pathogen;premature;Process;Regulation;Research;RNA;Small RNA;Source;Spirochaeta genus;Temperature;Ticks;Transcript;Transcription Initiation Site;transcriptome sequencing;Untranslated Regions;vector-borne;Work

PROJECT_TITLE: RNA-mediated gene regulation in the Lyme disease pathogen


NIH_SPENDING_CATS: Digestive Diseases;Genetics

PI_NAMEs: FARRELL, JEFFREY  (contact)

PROJECT_TERMS: 3' Untranslated Regions;Address;Adopted;Animals;Area;Atlases;Behavior;Biological Models;Biomechanics;carbonate dehydratase;Cell Differentiation process;cell injury;cell type;Cells;Cellular biology;Chick;Collaborations;Collection;Colorectal Cancer;Cues;Data;Data Analyses;Development;Developmental Biology;differential expression;Disease;DNA Damage;Duct (organ) structure;Elements;Embryo;Embryonic Development;Epithelial Cells;Epithelium;Exclusion;Exhibits;experience;Fluid Balance;Future;Gene Expression;gene regulatory network;Genes;Genetic;Genetic Transcription;Germ Cells;Goals;Human;Hybrid Cells;hybrid gene;Hybrids;Image;Individual;Inflammatory Bowel Diseases;insight;Intestinal Diseases;intestinal epithelium;Intestinal Hormones;Intestines;Investigation;Ions;kinetic model;Label;Maternal Messenger RNA;mechanical force;Mechanics;Mediating;Mesenchyme;Mesoderm;Messenger RNA;Modeling;Molecular Profiling;Monitor;Morphology;Mucous body substance;multipotent cell;Names;novel;Pericytes;Peristalsis;Population;Process;Production;programs;Proliferating;Publishing;receptor;Recording of previous events;regenerative biology;Regulation;Research;Research Personnel;Resolution;Resources;response;RNA;RNA Stability;Shapes;Signal Transduction;single cell genomics;single-cell RNA sequencing;Smooth Muscle;Smooth Muscle Myocytes;Specific qualifier value;Structure;Structure of primordial sex cell;temporal measurement;Tissues;tool;Transcript;transcription factor;Transcriptional Regulation;Vertebrates;Work;Zebrafish;zebrafish development

PROJECT_TITLE: Transcriptional Control of Cell Specification and Differentiation During Zebrafish Development


PI_NAMEs: ROGERS, KATHERINE  (contact)

PROJECT_TERMS: Adult;Biological Models;Biological Process;Cells;Development;Devices;digital;DNA;Embryo;embryo tissue;Embryonic Development;experience;fly;Friends;Gene Expression;Gene Expression Profile;Genes;Genetic;In Vitro;in vivo;Mediating;Methods;Microscopy;Modeling;Molecular;morphogens;Neural tube;Normal tissue morphology;novel;optogenetics;Output;Pattern;pharmacologic;Process;Resolution;response;Signal Pathway;Signal Transduction;Signaling Molecule;spatiotemporal;Specific qualifier value;Stereotyping;Tissue-Specific Gene Expression;Tissues;tool;Wing;Zebrafish;zebrafish development

PROJECT_TITLE: Decoding developmental signaling during zebrafish embryogenesis


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Childhood Obesity;Clinical Research;Eating Disorders;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Nutrition;Obesity;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Social Determinants of Health

PI_NAMEs: CHEON, BOBBY  (contact)

PROJECT_TERMS: 18 year old;Adolescence;Adolescent;Adult;Age;Appetitive Behavior;Attitude;Behavior;Behavioral;Behavioral Mechanisms;Behavioral Sciences;behavioral study;Body mass index;Breathing;Cardiometabolic Disease;cardiometabolism;Child;Child Psychology;Childhood;Consumption;Data;deprivation;Desire for food;Development;Diet;Diet Habits;dietary;Dietary Practices;Disadvantaged;Distress;early experience;Eating;Eating Behavior;eating in absence of hunger;Education;Energy consumption;Energy Intake;Esthesia;examination questions;Exhibits;experience;experimental study;Exposure to;Family;fast food;Fatty acid glycerol esters;Feeling;Food;food consumption;Food Preferences;Future;good diet;Growth;Health;Healthy Eating;healthy lifestyle;high body mass index;high risk;Hunger;Hyperphagia;Income;indexing;Individual;intergenerational;Intervention;Journals;Laboratories;Laboratory Study;Life;Life Cycle Stages;Linear Regressions;Link;Longitudinal cohort study;Longitudinal Studies;Longitudinal trends;low socioeconomic status;Manuscripts;Measures;Mediating;Metabolic;Metabolic syndrome;Methods;mortality risk;Motivation;National Institute of Child Health and Human Development;negative affect;Obesity;obesity risk;obesogenic;Outcome;Parents;Participant;Pathway interactions;Patient Self-Report;peer;Perception;perinatal health;Persons;Physiological;Physiology;population health;Predisposition;preference;Pregnancy;pregnant;Premature Birth;Premature Infant;programs;psychologic;Psychological Tests;psychosocial;Psychosocial Influences;Publications;Publishing;Reporting;Research;Research Activity;Resources;Risk;Role;Satiation;Schools;Shapes;Shoulder;Signal Transduction;social;social disparities;Social Sciences;Social status;social stressor;socioeconomic disadvantage;socioeconomic disparity;Socioeconomic Status;socioeconomics;Standardization;Statistical Methods;Stress;sugar;sweetened beverage;Testing;therapy design;therapy development;Unhealthy Diet;United States;Work

PROJECT_TITLE: Psychosocial influences on appetite and eating behavior


NIH_SPENDING_CATS: Clinical Research;Contraception/Reproduction;Genetics;Infertility;Pediatric;Rare Diseases;Women's Health Research

PI_NAMEs: GOMEZ-LOBO, VERONICA  (contact)

PROJECT_TERMS: Adolescence;Adolescent;Adult;Age;Anatomy;Cadaver;Cardiopulmonary;Cell Nucleus;Cells;Child;Childhood;Classical galactosemia;clinical phenotype;Country;Cryopreservation;Data;Databases;design;Development;digital;diminished ovarian reserve;Dissection;Estradiol;Evaluation;expectation;Female;Fertility;fertility preservation;Freezing;Future;Galactosemias;Gynecology;Histologic;Histology;Hormones;Image;Individual;Institutional Review Boards;Learning;Methods;Organ Donor;Ovarian;ovarian reserve;Ovarian Stimulations;Ovarian Tissue;Ovarian tissue cryopreservation;Ovary;Participant;Patients;Persons;Physiology;pregnant;Premature Menopause;prepuberty;primary ovarian insufficiency;Process;programs;Protocols documentation;repository;Research;Research Personnel;Risk;RNA;Sex Characteristics;Sexual Development;single nucleus RNA-sequencing;Slide;Structure;Tissue Banks;Tissue Sample;Tissues;transcriptome;Turner's Syndrome;Variant;Y Chromosome;young adult

PROJECT_TITLE: Ovarian tissue for fertility preservation-which will involve 2 IRB approved protocols: 000106 and 000715


NIH_SPENDING_CATS: Clinical Research;Congenital Structural Anomalies;Contraception/Reproduction;Pediatric;Rare Diseases;Women's Health Research

PROJECT_TERMS: Adolescent;Adult;ambiguous genitalia;Androgen Receptor;Androgen-Insensitivity Syndrome;Androgens;AR gene;Benefits and Risks;Blood;Body part;bone;Cardiovascular system;Childhood;Clinical;Clinical Data;Clinical Research;Code;congenital anomaly;Data;Data Collection;Databases;design;Diagnosis;Disease;Endocrine;Enrollment;Evaluation;Family member;Female;Female Genital Neoplasms;girls;Gynecologic;Gynecology;Health;Hormonal;Hormones;Human;Hypospadias;Immune;Immunologics;improved;Incidence;Individual;Infertility;information gathering;innovation;Knowledge;male;Mediating;Medical;member;men;Metabolic;Muscle;National Institute of Child Health and Human Development;Natural History;Neurologic;Nursing Faculty;Patients;Persons;Phenotype;Population Heterogeneity;Prevalence;proband;Process;Protocols documentation;Puberty;Quality of life;rare condition;Rare Diseases;receptor;Receptor Gene;recruit;Reifenstein's Syndrome;reproductive;reproductive tract;Research;Research Personnel;Risk;Role;sample collection;Skin;Specimen;Stimulus;Students;Surgical Management;System;Testing;Testosterone;Time;Tissues;tumor;United States National Institutes of Health;Virilism;Woman

PROJECT_TITLE: Rare conditions in PAG-which will involve 4 other protocols


NIH_SPENDING_CATS: Biotechnology;Contraception/Reproduction;Genetics;Human Genome;Infertility;Pediatric;Rare Diseases;Women's Health Research

PI_NAMEs: ROSIN, LEAH  (contact)

PROJECT_TERMS: 3-Dimensional;Age;Alleles;Aneuploidy;Behavior;Biological Models;Biology;Bypass;cell type;Cells;chromosome missegregation;Chromosome Pairing;Chromosome Segregation;Chromosome Structures;Chromosomes;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Communication;Congenital chromosomal disease;design;DNA;Down's Syndrome;egg;Event;Fertility;Fertility Disorders;Genetic;Genetic Recombination;genome editing;Genomic approach;Genomic Instability;Genomics;Germ Cells;Germ Lines;Homologous Gene;Human;Human Biology;human female;imaging approach;Infertility;Insecta;insight;Kinetochores;Mammals;Meiosis;Meiotic Recombination;Mus;National Heart, Lung, and Blood Institute;novel;Nuclear;Oocytes;Phenotype;Process;Production;Publishing;Regulation;segregation;Sister;sperm cell;Spontaneous abortion;System;therapeutic target;Turner's Syndrome

PROJECT_TITLE: Investigating chromosome structure and function across species using Oligopaints and genomics


NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Childhood Obesity;Clinical Research;Congenital Structural Anomalies;Contraception/Reproduction;Estrogen;Genetics;Infertility;Obesity;Osteoporosis;Patient Safety;Pediatric;Pediatric Cancer;Prevention;Rare Diseases;Women's Health Research

PI_NAMEs: GORDON, CATHERINE  (contact)

PROJECT_TERMS: Adolescence;Adolescent;adolescent woman;Adult;Affect;Age;Age Years;Androgen Receptor;Androgen-Insensitivity Syndrome;Androgens;AR gene;Assessment tool;Autoimmune;Autoimmune Diseases;behavioral health;Benign;Birth;Black race;Blood Vessels;Body Composition;bone;Bone Density;Bone Development;bone health;Bone Marrow;bone mass;bone turnover;cardiovascular health;cardiovascular risk factor;chemotherapy;Child;Childhood;childhood cancer survivor;Chondrogenic Neoplasm;Chondroma;Chronic;Chronic Disease;Clinical;clinical practice;Clinical Trials;Collaborations;common treatment;Complete Androgen-Insensitivity Syndrome;Data;Defect;Deformity;Delayed Puberty;Development;Diagnosis;Disease;dosage;Dual-Energy X-Ray Absorptiometry;Emotional;Enchondromatosis;Endocrine Glands;Estrogen deficiency;Estrogen Replacements;Estrogens;Etiology;Excision;experience;Facial asymmetry;Female infertility;Fracture;fracture risk;Fragile X Syndrome;Gait abnormality;Genetic;genetic disorder diagnosis;genetic testing;Genotype;Gonadal structure;grasp;Gynecologic;Hand Strength;Health;Hormonal;Hormone Replacement Preparation;Hormone replacement therapy;Hormones;Iatrogenesis;Image;Imaging Device;Individual;Infertility;Inflammatory Bowel Diseases;insight;interest;Irregular Menstruation;joint mobilization;Joints;Laboratories;Leg;Length;Life;Limb structure;Link;Maffucci Syndrome;Malignant Neoplasms;Measurement;Measures;Menopausal Symptom;Menstrual cycle;Metabolic;Metaphysis;Molecular;Mood Disorders;Muscle;Mutation;Natural History;nutrition;Obesity;Observational Study;Operative Surgical Procedures;Organ;Osteoporosis;Outcome;ovarian dysfunction;Pain;Patients;Peripheral;Phenotype;Physical activity;physical conditioning;Physiological;Play;Population;Premenopause;prevent;primary ovarian insufficiency;Progeria;Progesterone;Puberty;Radiation;radiological imaging;rare condition;Rare Diseases;rare genetic disorder;Regimen;Reifenstein's Syndrome;Reporting;Research;Resistance;Resolution;response;Risk Factors;Role;scoliosis;Sex Differentiation Disorders;skeletal;skeletal abnormality;Skeletal bone;Skeletal Muscle;Skeleton;Skin;skin color;Skin Pigmentation;Spectrophotometry;Structure;Swelling;Syndrome;tool;treatment group;tumor;Turner's Syndrome;Universities;vasomotor symptoms;Veronica;Woman;X-Ray Computed Tomography;young woman;Youth

PROJECT_TITLE: Adolescent Bone Density & Body Composition Section


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Congenital Structural Anomalies;Genetics;Human Genome;Pediatric;Rare Diseases

PI_NAMEs: FERREIRA, CARLOS  (contact)

PROJECT_TERMS: Affect;Animal Disease Models;Animal Model;Bioinformatics;Biology;Birth;bone;burden of illness;calcification;Calendar;Caring;Cartilage;Cell model;Classification;Clinic;Clinical;Clinical Research;Clinical Trials;Collaborations;Differential Diagnosis;Disease;disease classification;enzyme activity;Familial hypophosphatemic bone disease;Functional disorder;Genes;Genetic;Genetic Predisposition to Disease;genetic variant;Genomics;Genotype;Goals;Growth;Heritability;Hormones;improved;Individual;inorganic phosphate;International;Laboratories;Lesion;Manuscripts;Medical;Medicine;Metabolism;Molecular;Morbidity - disease rate;mouse model;National Heart, Lung, and Blood Institute;next generation sequencing;novel;Operative Surgical Procedures;osteoglophonic dysplasia;Paper;Pathway interactions;Patients;Phenotype;Publishing;Rare Diseases;Reporting;skeletal;skeletal disorder;skeletal dysplasia;Societies;targeted treatment;Technology;translational research program;Work

PROJECT_TITLE: Skeletal Genomics


ACTIVITY: ZIB

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Contraception/Reproduction;Infectious Diseases;Prevention;Women's Health Research

PROJECT_TERMS: Address;Agreement;AIDS prevention;Biological Testing;Characteristics;chemical synthesis;Chemistry;Clinical;clinical efficacy;Clinical Investigator;clinical research site;Clinical Trials;Clinical Trials Network;Contraceptive Agents;Contraceptive methods;Contracts;Cooperative Research and Development Agreement;Couples;design;Development;Devices;Dose;drug candidate;Drug Delivery Systems;efficacy study;Evaluation;first-in-human;Formulation;Gel;Goals;good laboratory practice;Good Manufacturing Process;HIV Infections;Hormonal;Human;Injectable;innovation;Institution;International;Lead;Male Contraceptive Agents;manufacture;Mediation;meetings;men;method development;Methods;Mission;National Institute of Child Health and Human Development;next generation;novel;novel therapeutics;Pharmaceutical Preparations;Phase;preclinical evaluation;preclinical study;Pregnancy;Preparation;prevent;Prevention;Program Development;programs;Qualifying;Research;research and development;research clinical testing;Research Personnel;Safety;Schedule;Scientist;Site;Technology;Technology Transfer;Testing;Toxicology;Training;Translating;Vagina;Vaginal Ring;Woman

PROJECT_TITLE: Development of novel contraceptive methods for men and women


ACTIVITY: ZIC

PI_NAMEs: SCHRAM, VINCENT  (contact)

PROJECT_TERMS: Agreement;Area;Authorship;Binding Proteins;Calendar;CCRL2 gene;Charge;Collaborations;Color;Communities;Companions;Computer software;Core Facility;Cryopreservation;Cryoultramicrotomy;Data;Data Analyses;design;detector;Dissection;Dyes;Educational workshop;Electron Microscope;Electron Microscopy;Elements;Equipment;Floor;Fluorescence;Goals;Head;Histology;Hour;Image;Image Analysis;image processing;imaging facilities;Immunofluorescence Immunologic;instrument;Lasers;Libraries;Light;light microscopy;Membrane;Methods;Microscope;Microscopy;Microtome - medical device;National Institute of Child Health and Human Development;National Institute of Neurological Disorders and Stroke;Netherlands;Neurosciences;operation;Paper;Paraffin Embedding;Perfusion;Persons;Plant Resins;Preparation;Procedures;Process;Protocols documentation;Publications;Research;Research Personnel;Resources;RNA;Rodent;sample fixation;Sampling;Scanning;Scientist;service providers;Services;Slide;Specimen;Stains;Techniques;Thinness;Time;tissue preparation;tissue processing;Tissues;Training;Transmission Electron Microscopy;transmission process;ultra high resolution;Universities;usability;Work

PROJECT_TITLE: NICHD Microscopy and Imaging Core Facility


NIH_SPENDING_CATS: Genetics;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

PI_NAMEs: PFEIFER, KARL ERIC (contact)

PROJECT_TERMS: anti-cancer;blastocyst;Chemotherapy-Oncologic Procedure;design;Electroporation;Embryo;embryonic stem cell;Enhancers;Epigenetic Process;ES Cell Line;Fertility;Gene Expression Regulation;Genome Stability;Goals;Hematopoiesis;immune function;Immune system;Implant;Injections;Intramural Research Program;Modeling;mouse model;Mus;Mutant Strains Mice;Mutate;National Institute of Child Health and Human Development;novel;Operative Surgical Procedures;Pathway interactions;Procedures;Protocols documentation;Research;Research Personnel;Research Support;RNA metabolism;Scientist;Signal Pathway;stem cell biology;T-Cell Development;Thymus Gland;United States National Institutes of Health;Work;zygote

PROJECT_TITLE: Generating new mouse models


ACTIVITY: ZIE

PI_NAMEs: DECHERNEY, ALAN  (contact)

PROJECT_TERMS: Accreditation;American;Basic Science;Biometry;Certification;Childhood;Clinical;Clinical Sciences;Clinical Services;clinical training;Discipline of obstetrics;Educational Curriculum;Educational process of instructing;Endocrine;Endocrinology;Environment;Evaluation;Faculty;Fellowship;Fertility;Future;Government;graduate medical education;Gynecology;Infertility;Institution;Intramural Research Program;Laboratory Research;Manuscripts;Medical;Medical center;Medical Genetics;Military Personnel;National Institute of Child Health and Human Development;Operative Surgical Procedures;Peer Review;Physicians;professor;programs;Publishing;Reproduction;reproductive;Reproductive Endocrinology;Research;Research Personnel;Research Project Grants;Rotation;Services;Time;Training;Training Programs;Translational Research;United States National Institutes of Health;Universities

PROJECT_TITLE: Reproductive Endocrinology And Infertility Clinical Training Program


NIH_SPENDING_CATS: Clinical Research;Congenital Structural Anomalies;Contraception/Reproduction;Infertility;Pediatric;Social Determinants of Health;Women's Health Research

PROJECT_TERMS: 21 year old;Accreditation;Adolescent;Age;Area;Birth;Career Mobility;Caring;Child;Childhood;Complex;congenital anomaly;Diagnosis;Discipline of obstetrics;Disease;Education;Ensure;Faculty;Family;Fellowship;fertility preservation;girls;Goals;Gynecologic;Gynecologist;Gynecology;Hospitals;Infertility;Institution;Knowledge;Learning;malformation;Malignant Female Reproductive System Neoplasm;medical complication;Mission;National Institute of Child Health and Human Development;older women;Patient Care;pediatrician;Pelvis;programs;reproductive;Reproductive Endocrinology;Research;research and development;Research Support;Residencies;sex development disorder;Sexual abuse;skills;Training;Training Programs;transgender;Vulva;Washington

PROJECT_TITLE: Pediatric and Adolescent Gynecology Training Program


ADMINISTERING_IC: FD

ED_INST_TYPE: SCHOOLS OF PHARMACY

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: BALTIMORE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PHARMACOLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: Narrative Statement We propose continuation of M-CERSI that fosters FDA-oriented research, as well as regulatory science information sharing opportunities. The Center's mission is to foster the development of regulatory science – the science of developing new tools, standards and approaches to assess the safety, efficacy, quality and performance of FDA-regulated products. Activities leverage the close geographic proximity between University of Maryland and FDA's main campus.

PI_NAMEs: BENTLEY, WILLIAM E.;POLLI, JAMES E (contact)

PROGRAM_OFFICER_NAME: SEPULVEDA, KRISTIN

PROJECT_TITLE: University of Maryland Center of Excellence in Regulatory Science and Innovation


ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE To address the FDA’s need for expanded regulatory science capabilities, the Research Triangle Center of Excellence in Regulatory Science and Innovation (Triangle CERSI) will provide a generative community for regulators, academia, and industry while serving as a one-stop-shop accelerator to meet current and evolving needs of regulatory science. The Triangle CERSI represents a collaboration of four leading academic institutions in North Carolina that are in close proximity (the University of North Carolina at Chapel Hill, Duke University, North Carolina State University, and North Carolina Central University). The Triangle CERSI aims to fully deploy our broad, collective expertise and close collaborations with FDA personnel to create and expedite utilization of important new knowledge in regulatory science and to provide an infrastructure of flexible and innovative toolsets to enrich the efficiency and value of FDA activities as part of the national CERSI program.

PI_NAMEs: HALABI, SUSAN ;MENTZ, ROBERT JOHN;SAMEI, EHSAN ;WATKINS, PAUL B (contact)

PROGRAM_OFFICER_NAME: CHEN, TRACY


ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: NARRATIVE The UCSF-Stanford Center of Excellence in Regulatory Sciences and Innovation (CERSI) conducts collaborative research in innovative regulatory science. This research enhances the FDA’s public health mission including the evaluation of safe and effective medical products. In addition, the CERSI develops training and outreach programs for the purpose of training students, postdoctoral fellows and career scientists in regulatory sciences.

PI_NAMEs: ALTMAN, RUSS BIAGIO;GIACOMINI, KATHLEEN M (contact)

PROJECT_TITLE: UCSF-Stanford Center of Excellence in Regulatory Science and Innovation


ADMINISTERING_IC: DA

FUNDING_MECHANISM: NON SBIR/STTR CONTRACTS

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

ORG_CITY: SAINT LOUIS

ORG_NAME: CERTARA USA, INC.

ORG_STATE: MO

PI_NAMEs: DUDDY, STEVE  (contact)

PROJECT_TERMS: Address;Biological Assay;Biological Products;Clinical;Clinical Research;Collaborations;Contractor;Data Analyses;design;Development;Development Plans;drug development;drug discovery;Electronic Mail;Feedback;healing;in silico;In Vitro;in vivo Model;lead optimization;Logistics;member;model development;National Institute of Neurological Disorders and Stroke;Nervous System Disorder;Neurosciences;Oligonucleotides;pharmacokinetics and pharmacodynamics;Pharmacology;Pharmacology and Toxicology;Pharmacology Study;pre-clinical;Program Development;programs;Recommendation;Resources;Role;safety study;screening;Services;Strategic Planning;symposium;Testing;Toxicology;United States National Institutes of Health

PROJECT_TITLE: NINDS, NIH BPN, NIH HEAL AND OTHER NIH NEUROSCIENCE-FOCUSED DRUG DISCOVERY AND DEVELOPMENT PROGRAMS WITH TOXICOLOGY CONSULTING SERVICES


ADMINISTERING_IC: CK

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: National Center for Emerging and Zoonotic Infectious Diseases

ORG_CITY: ATLANTA

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PI_NAMEs: JACOB, JESSE THOMAS (contact)

PROJECT_TITLE: RFA-CK-20-004: Prevention Epicenter of Emory and Collaborating Healthcare Facilities (PEACH II)


ORG_CITY: CHICAGO

ORG_NAME: RUSH UNIVERSITY MEDICAL CENTER

ORG_STATE: IL

PI_NAMEs: HAYDEN, MARY KATHERINE (contact);TRICK, WILLIAM E

PROJECT_TITLE: CK20-004, Chicago Prevention and Intervention Epicenter III (CPIE-III)


ORG_CITY: LA JOLLA

ORG_NAME: J. CRAIG VENTER INSTITUTE, INC.

PI_NAMEs: FOUTS, DERRICK E (contact)

PROJECT_TITLE: CK20-004, J. Craig Venter Insitute and Cleveland VA Prevention and Intervention Epicenter


ADMINISTERING_IC: CA

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: MANHASSET

ORG_NAME: FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH

ORG_STATE: NY

PHR: Project Narrative: The most recent community needs assessment denoted cancer as the most significant health priority in Nassau and Suffolk Counties and the second most significant in Queens County. Strategies to decrease cancer burden were identified and included increased outreach and leveraging education and wellness programs to all communities; diverse, underserved, and anyone in our catchment area. With our current system in place Northwell Health NCORP can affect change on health outcomes in the community.

PI_NAMEs: VINCIGUERRA, VINCENT P (contact)

PROGRAM_OFFICER_NAME: WHITE, VANESSA

PROJECT_TERMS: Acceleration;Adherence;Affect;Aftercare;anti-cancer research;base;Cancer Burden;cancer care;cancer clinical trial;Cancer Control;Cancer Patient;cancer prevention;cancer therapy;care delivery;Catchment Area;clinical practice;Clinical Research;Clinical Trials;Collaborations;Communication;Communities;Community Clinical Oncology Program;Community Healthcare;Community Physician;Community Practice;Continuity of Patient Care;County;Dedications;demographics;Diagnosis;Diagnostic;Economics;Education;effective therapy;evidence base;Evidence based practice;Goals;Health;health equity;Health Personnel;Health Priorities;Health Services;Health system;Healthcare Systems;improved;Knowledge;knowledge translation;Malignant Neoplasms;Measures;medical specialties;Medicine;Minority Recruitment;Mission;multidisciplinary;National Cancer Institute;Needs Assessment;Operative Surgical Procedures;Outcome;outreach;palliation;Patient Recruitments;Patient-Focused Outcomes;Patients;performance site;Physicians;Population;Prevention;Primary Care;programs;Quality of life;Reduce health disparities;Research;screening;Services;Site;social;System;Techniques;Technology;Underrepresented Populations;Underserved Population;Wellness Program;Woman;Work

PROJECT_TITLE: Northwell Health NCORP


NIH_SPENDING_CATS: Aging;Biotechnology;Cancer;Climate-Related Exposures and Conditions;Genetics;HIV/AIDS;Human Genome;Neuroblastoma;Neurosciences;Orphan Drug;Prevention;Rare Diseases;Social Determinants of Health

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PI_NAMEs: OPRESKO, PATRICIA L (contact)

PROGRAM_OFFICER_NAME: PTAK, KRZYSZTOF

PROJECT_TERMS: adaptive immunity;Aging;Air Pollution;Antigens;Area;ataxia telangiectasia mutated protein;base;Basic Science;Biological;biological adaptation to stress;Biological Assay;Biological Markers;Biology;Biotin;cancer cell;Cancer Center;cancer diagnosis;cancer type;carcinogenesis;Catchment Area;CD8B1 gene;Cell Aging;Cell Death;Cells;Chemicals;Chromosome abnormality;Cisplatin;clinical application;Clinical Research;Collaborations;Collection;Communication;daughter cell;Deamination;Dedications;Depurination;Development;diagnostic strategy;DNA Adducts;DNA Damage;DNA lesion;DNA Repair;DNA Repair Enzymes;DNA Repair Gene;DNA Repair Pathway;DNA replication fork;DNA-Directed DNA Polymerase;Doctor of Philosophy;drug discovery;Education;Environmental Health;Environmental Risk Factor;Epigenetic Process;Faculty;Functional disorder;fundamental research;Funding;Genes;Genetic Materials;Genome;genome integrity;Genome Stability;Genomic Instability;Genomics;Genotoxic Stress;genotoxicity;Goals;Growth;Human body;human DNA;Immune;Immune response;Immunologic Factors;Inflammatory;inhibitor;innovation;insight;inter-institutional;interest;International;Ionizing radiation;kinase inhibitor;Laboratories;Link;Malignant Neoplasms;member;Mentors;Mitochondria;mitochondrial dysfunction;Molecular;molecular oncology;Mothers;mouse model;multidisciplinary;Mus;Mutation;Natural Immunity;neoplastic cell;Neuroblastoma;next generation;novel;novel therapeutics;Occupational Health;Oncogene Activation;Oral;Outcome;oxidation;oxidative damage;oxidative DNA damage;Oxidative Stress;Pathway interactions;Peer Review;Pharmacology;Phase;preclinical study;Prevention;Prevention strategy;Process;professor;programs;Proteins;Publications;Publishing;Radiation induced damage;radiation mitigation;Radon;Reactive Oxygen Species;real-time images;recruit;repaired;Research;research faculty;Research Personnel;Research Support;response;Risk Factors;Role;Schools;Scientist;Seminal;Series;single molecule;small molecule;Source;stem;Structure;Sunlight;synergism;telomere;Telomere Maintenance;Telomere Pathway;Therapeutic;three dimensional cell culture;tool;Translating;Translations;treatment strategy;tumor;Tumor Suppressor Genes;Universities;Validation;Work;Xenograft procedure

PROJECT_TITLE: Genome Stability Program

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


NIH_SPENDING_CATS: Aging;Biotechnology;Cancer;Climate-Related Exposures and Conditions;Genetics;Human Genome;Neuroblastoma;Neurosciences;Orphan Drug;Prevention;Rare Diseases;Social Determinants of Health

PROJECT_TERMS: adaptive immunity;Aging;Air Pollution;Area;ataxia telangiectasia mutated protein;base;Basic Science;Beauty;Biological;biological adaptation to stress;Biological Assay;Biological Markers;Biology;Biotin;cancer cell;Cancer Center;cancer diagnosis;cancer type;carcinogenesis;Catchment Area;Cell Aging;Cell Death;Cells;Chemicals;Chromosome abnormality;Cisplatin;clinical application;Clinical Research;Collaborations;Collection;Communication;daughter cell;Deamination;Dedications;Depurination;Development;diagnostic strategy;DNA Adducts;DNA Damage;DNA lesion;DNA Repair;DNA Repair Enzymes;DNA Repair Gene;DNA Repair Pathway;DNA replication fork;DNA-Directed DNA Polymerase;Doctor of Philosophy;drug discovery;Education;Environmental Health;Environmental Risk Factor;Epigenetic Process;Faculty;Functional disorder;fundamental research;Funding;Genes;Genetic Materials;Genome;genome integrity;Genome Stability;Genomic Instability;Genomics;Genotoxic Stress;genotoxicity;Goals;Growth;Human body;human DNA;Immune response;Immunologic Factors;Inflammatory;inhibitor;innovation;insight;inter-institutional;interest;International;Ionizing radiation;kinase inhibitor;Laboratories;Link;Malignant Neoplasms;member;Mentors;Mitochondria;mitochondrial dysfunction;Molecular;molecular oncology;Mothers;mouse model;multidisciplinary;Mus;Mutation;Natural Immunity;neoplastic cell;Neuroblastoma;next generation;novel;novel therapeutics;Occupational Health;Oncogene Activation;Oral;Outcome;oxidation;oxidative damage;oxidative DNA damage;Oxidative Stress;Pathway interactions;Peer Review;Pharmacology;Phase;preclinical study;Prevention;Prevention strategy;Process;professor;programs;Proteins;Publications;Publishing;Radiation induced damage;radiation mitigation;Radon;Reactive Oxygen Species;real-time images;recruit;repaired;Research;research faculty;Research Personnel;Research Support;response;Risk Factors;Role;Schools;Scientist;Seminal;Series;single molecule;small molecule;Source;stem;Structure;Sunlight;synergism;telomere;Telomere Maintenance;Telomere Pathway;Therapeutic;three dimensional cell culture;tool;Translating;Translations;treatment strategy;tumor;Tumor Suppressor Genes;Universities;Validation;Work;Xenograft procedure


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Immunotherapy;Social Determinants of Health

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PI_NAMEs: KAST, WIJBE MARTIN (contact)

PROGRAM_OFFICER_NAME: HE, MIN

PROJECT_TERMS: Administrative Supplement;anti-cancer research;Antibodies;Basic Cancer Research;Basic Science;Biological Markers;Breast;Breast Cancer Model;Breast Melanoma;Budgets;cancer cell;Cancer Center Support Grant;cancer clinical trial;cancer education;cancer immunotherapy;Cancer Patient;cancer prevention;Cancer Vaccines;CD8B1 gene;Cell Separation;Cell surface;Cell Therapy;Cells;Charge;chemoradiation;chemotherapy;Chromatin Loop;Clinical;Clinical Research;Clinical Sciences;Clinical Trials;Clinical Trials Cooperative Group;Clustered Regularly Interspaced Short Palindromic Repeats;Color;Communication;Complex;Comprehensive Cancer Center;Consultations;Copy Number Polymorphism;Correlative Study;cost;cost effective;Cytometry;cytotoxic;Data;Diagnostic;Diet;Direct Costs;Disease Outcome;Doctor of Philosophy;Education;ENG gene;epigenomics;Equipment;Faculty;Fasting;Feedback;Flow Cytometry;Fluorescence;Foundations;Funding;Genome;Genomics;Genomics Shared Resource;Grant;Gynecologic Oncology Group;high throughput analysis;Immune;Immune checkpoint inhibitor;immune function;Immunologic Monitoring;immunological status;Immunologics;immunoregulation;Immunotherapy;immunotherapy clinical trials;improved;Institution;instrument;ipilimumab;Laboratories;Last Name;Local Therapy;Malignant - descriptor;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Mediating;member;mesenchymal stromal cell;Methods;Mission;Molecular;mutant;Names;Natural Killer Cells;Neoplasm Circulating Cells;Neuroblastoma;Oncology;Outcome;Pathogenesis;Pathology;Patients;Peer Review;Phenotype;Population;pre-clinical;programs;prostate cancer risk;Proteins;Publications;Regulation;Reporting;Research;Research Design;Research Personnel;Research Support;Resolution;Resource Sharing;response;Role;satisfaction;Services;Sorting;Surveys;System;T cell clonality;Technology;Therapeutic;Training and Education;transcriptome sequencing;translational cancer research;Translational Research;Tropism;tumor heterogeneity;tumor microenvironment;tumor-immune system interactions;Tumor-Infiltrating Lymphocytes;Underserved Population;University of Southern California Norris Cancer Center;vector

PROJECT_TITLE: Flow Cytometry Core


ORG_CITY: OMAHA

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PI_NAMEs: CAPLAN, STEVEN H (contact)

PROGRAM_OFFICER_NAME: BELIN, PRECILLA L

PROJECT_TERMS: Cancer Center;cell fixing;Cells;Communities;Consultations;Core Facility;Coupled;Data;Dedications;design;Development;experimental study;Fees;Goals;Image;Image Analysis;image processing;Imaging Techniques;innovation;Laser Scanning Confocal Microscopy;light microscopy;Lighting;live cell imaging;Maintenance;Medical center;member;Microscope;Microscopic;microscopic imaging;Microscopy;Modeling;molecular imaging;Nebraska;notch protein;Optics;outreach;Photobleaching;Publishing;reconstruction;Research;Research Personnel;Resolution;Resource Sharing;Services;single molecule;Structure;superresolution microscopy;Techniques;Technology;Three-Dimensional Imaging;Tissues;Training;ultra high resolution;Universities

PROJECT_TITLE: Advanced Microscopy Shared Resource


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

PI_NAMEs: VIGNERON, DANIEL B (contact)

PROGRAM_OFFICER_NAME: BARRY, ROBERT LEO II

PROJECT_TERMS: 2,4-Dinitrophenol;Administrative Supplement;Area;biomedical imaging;Bioreactors;Calibration;Carbon;Cell Culture Techniques;Chemistry;Client;Clinical;Clinical Research;clinical translation;Collaborations;Communication;Communities;Computer software;Data;design;Development;Doctor of Philosophy;doctoral student;Documentation;Dose;driving force;Educational workshop;Electronic Mail;Environment;Equipment;Event;experience;Extramural Activities;Faculty;Feedback;Funding;Generations;Geography;Goals;Growth and Development function;Human;Human Resources;human subject;imaging approach;imaging modality;Imaging Phantoms;Imaging Techniques;improved;Individual;Industry;Institution;instrumentation;interest;International;lectures;Magnetic Resonance Imaging;Mentors;Methods;molecular imaging;new technology;Newsletter;novel;online resource;outreach;Paper;Pharmacy facility;Physiologic pulse;Postdoctoral Fellow;pre-clinical;Pre-Clinical Model;pre-clinical research;Preparation;Production;program dissemination;programs;Protocols documentation;Publications;radiological imaging;Radiology Specialty;Recipe;reconstruction;Reporting;Research;Research Personnel;research study;Resources;sabbatical;Sampling;Services;Site;skills;social media;software development;Source;Sterility;Surveys;synergism;Techniques;Technology;technology development;technology research and development;Test Result;tissue culture;tool;Training;Training Activity;training opportunity;Training Programs;Translational Research;Translations;Update;virtual;Visit;web site

PROJECT_TITLE: Hyperpolarized MRI Technology Resource Center


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: LEXINGTON

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: Project Narrative There are no known evidence-based interventions targeting the prevention of HIV transmission among older Black women in the U.S., which is a major public health concern as there is a growing aging Black American population living with HIV. The objective of this innovative project is to develop and test the feasibility, acceptability, usability, and preliminary efficacy of Woman to Woman (W2W), an HIV intervention for older Black women. The mentorship and training activities, combined with the implementation of the feasibility trial, within this BIRCWH supplement will provide the needed skills and data for the BIRCWH scholar, Dr. Laneshia Conner, to address comments for her competitive K01 to conduct a large scale randomized controlled trial to assess the impact of the W2W intervention in reducing HIV risk among older Black women.

PI_NAMEs: CURRY, THOMAS E (contact)

PROGRAM_OFFICER_NAME: FALCON-MORALES, EDGARDO

PROJECT_TERMS: acceptability and feasibility;Accounting;Address;Adult;Age;aged;Ageism;AIDS prevention;Area;base;behavior measurement;Behavior Therapy;black women;career;Communities;Complex;Data;Decision Making;Dedications;Environment;experience;feasibility testing;Female;Future;Goals;Heterosexuals;high risk behavior;HIV;HIV diagnosis;HIV Infections;HIV risk;Housing;improved;innovation;Intervention;Kentucky;Knowledge;Low income;Methodology;Methods;next generation;older adult;Outcome;Physiological;Pilot Projects;Population;Prevalence;prevention service;Procedures;programs;Protocols documentation;Public Health;racial minority population;randomized, clinical trials;Recording of previous events;recruit;Reporting;Reproductive Health;Research;Research Personnel;Risk;Risk Behaviors;risk perception;Scientist;Site;skill acquisition;skills;social stigma;therapy development;Training;transmission process;United States National Institutes of Health;Universities;usability;Woman;Women's Health

PROJECT_TITLE: Supplement for Kentucky BIRCWH Program: Training the Next Generation of Women's Health Scholars: Dr. Conner


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_DEPT: PEDIATRICS

PHR: Project Narrative The biguanide drug metformin that is widely used for the management of Type 2 diabetes is being evaluated as an anti- neoplastic agent in cancer trials including GBM. In this proposal we will investigate molecular markers for metformin therapy and mechanisms of resistance to metformin therapy in glioblastoma.

PI_NAMEs: DASGUPTA, BIPLAB  (contact)

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: adenylate kinase;Algorithms;Antineoplastic Agents;Biguanides;blood-brain barrier crossing;Brain;Cell Death;cell growth;Cell Line;Cell membrane;Classification;classification trees;clinical development;Clinical Trials;cohort;Combined Modality Therapy;complement C2a;Complex;Data;Data Analyses;Diffusion;Dose;efficacy evaluation;efficacy study;efficacy testing;experimental analysis;FDA approved;Gene Expression;Generations;Genes;Glioblastoma;Glucose;Glycolysis;Goals;Growth;improved;In Vitro;in vitro testing;in vivo;inhibitor;inhibitor therapy;Investigation;Kidney;kinase inhibitor;Knowledge;Liver;Malignant neoplasm of lung;Malignant Neoplasms;Messenger RNA;Metabolic;metabolic phenotype;Metformin;Methods;Methylation;Mitochondria;Molecular;Molecular Analysis;molecular marker;mouse model;Mutation;neoplastic cell;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutics;Oral;Osmosis;Outcome;Oxidative Phosphorylation;Pathway interactions;Penetration;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;promoter;protein expression;Proteomics;Pump;Pyruvate;pyruvate dehydrogenase;regression trees;Regulation;Resistance;resistance mechanism;responders and non-responders;response;Safety;safety study;sensor;Signal Transduction;Specificity;Stable Isotope Labeling;stem;stem cells;success;temozolomide;Testing;The Cancer Genome Atlas;Therapeutic;Therapeutic Effect;therapy resistant;Tissues;Toxic effect;Translating;tumor;tumor growth;tumor microenvironment;Tumor Subtype;Validation

PROJECT_TITLE: Mechanisms of Biguanide Sensitivity in GBM

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 1 Study Section[MCT1]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Brain Disorders;Genetics;Huntington's Disease;Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: HOUSTON

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF HOUSTON

ORG_STATE: TX

PHR: Project Narrative We develop the multiplexed super-resolution force spectroscopy to investigate the mechanism of ribosome translocation during protein synthesis. We will measure the power strokes from elongation factors and their mutants during ribosome translocation on modified mRNA sequences and in the presence of antibiotics. Our research will provide new model about the ribosome translocation with sub-codon steps and provide potential drug targets for the related diseases.

PI_NAMEs: WANG, YUHONG  (contact);XU, SHOUJUN

PROGRAM_OFFICER_NAME: CZAPLINSKI, KEVIN

PROJECT_TERMS: Acoustics;Affect;Amino Acids;Antibiotic Resistance;Antibiotics;base;Binding;Biological Assay;biophysical tools;CAG repeat;Cardiovascular Diseases;Cells;Child;Codon Nucleotides;Congenital Epilepsy;Degenerative Disorder;design;Detection;Disease;disease-causing mutation;DNA Tumor Viruses;Drug Targeting;Elongation Factor;Epilepsy;Exons;Funding;G-Quartets;Generations;Grant;GTP Binding;Guanosine Triphosphate;Health;Homologous Gene;Human;human disease;Huntington Disease;Huntington gene;improved;insight;Intellectual functioning disability;Kinetics;Knowledge;Legal patent;Location;Maintenance;Malignant Neoplasms;Manuscripts;Measurement;Measures;mechanical force;Messenger RNA;Methods;Modeling;Modification;Movement;multiplex detection;Muscle;mutant;Mutation;Neurons;new technology;new therapeutic target;novel;Nucleotides;Outcome;Paper;Peptide Elongation Factor G;Peptides;Phase;Phosphorylation;Phosphotransferases;Play;Positioning Attribute;Power stroke;Process;Protein Biosynthesis;Radiation;Reading Frames;Regulation;Research;Resistance;Resolution;Ribosomal RNA;Ribosomes;RNA;Role;Sampling;Scheme;sensor;Side;Spectrum Analysis;Structure;Techniques;therapeutic target;Time;Transfer RNA;Translational Regulation;Translations;translocase;ultra high resolution;Virus Diseases

PROJECT_TITLE: A novel force spectroscopy to study the ribosome power strokes and frameshifting

STUDY_SECTION: EBIT

STUDY_SECTION_NAME: Enabling Bioanalytical and Imaging Technologies Study Section[EBIT]


ADMINISTERING_IC: AI

FUNDING_MECHANISM: INTERAGENCY AGREEMENTS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities

PROJECT_TERMS: Biological Products;Clinical Trials;Names;National Institute of Allergy and Infectious Disease;Pharmacologic Substance;Price;programs;Vendor

PROJECT_TITLE: FY24-FY33 NIAID-DLA Pharmaceutical Vendor Program


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: NARRATIVE The proposed research will examine associations between measures of placental function and offspring cardiovascular outcomes across the life course and investigate the placenta as a mediator of racial and socioeconomic disparities in offspring cardiovascular disease (CVD). Results from this research will improve our understanding of the placental mechanisms underlying offspring CVD risk, which in the short-term, will improve identification of neonates who may benefit from enhanced monitoring and early intervention, and in the long-term, will inform development of gestational interventions to promote optimal cardiovascular health and mitigate disparities.

PI_NAMEs: FREEDMAN, ALEXA  (contact)

PROGRAM_OFFICER_NAME: SMITH, SHARON M

PROJECT_TERMS: Address;Adolescence;Adult;adverse pregnancy outcome;arterial stiffness;Award;Birth;Black race;Blood Pressure;Blood Vessels;Body mass index;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;Cardiovascular system;career;Cause of Death;Characteristics;Child;Childhood;Chronic Disease;Clinical;cohort;Coronary heart disease;Creativeness;Data;Data Collection;Data Sources;design;Development;disease disparity;Disparity;Disparity population;disparity reduction;Early Intervention;Epidemiologist;Evaluation;experience;Fetal Development;Fetal Growth;follow-up;Functional disorder;Funding;Generations;Goals;Health;health disparity;Histologic;Hypertension;Image Analysis;improved;in utero;Infant;Inflammatory;insight;intergenerational;Intervention;Knowledge;Left ventricular structure;Lesion;Life Cycle Stages;Longitudinal Studies;Longterm Follow-up;Maternal-Fetal Exchange;Measures;Mediating;Mediator;Medical Waste;Mentors;Mentorship;metabolic profile;Monitor;Morality;Morbidity - disease rate;mortality;neonate;novel;offspring;Organ;Outcome;Parents;Pathogenesis;Perinatal;Perinatal Epidemiology;perinatal intervention;perinatal period;Pilot Projects;Placenta;Play;population based;Positioning Attribute;Pregnancy;premature;Premature Birth;Prevalence;Process;racial disparity;Reporting;Research;Risk;Risk Factors;risk stratification;Role;Serum;Siblings;Small for Gestational Age Infant;social disparities;socioeconomic disadvantage;socioeconomic disparity;stillbirth;Stress;Structure;Techniques;Thick;Training;transmission process;Twin Multiple Birth;United Kingdom;United States;Work;young adult

PROJECT_TITLE: Placental contributions to disparities in offspring cardiovascular health across the life course

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(JA)]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Hematology;Microbiome;Nutrition

ORG_DEPT: SURGERY

PHR: Project Narrative There is a clinical need to support immune recovery in critically ill patients whose bone marrow dysfunction and immune suppression often lead to poor short and long term outcomes. Emerging evidence shows a critical role of the gut microbiome in controlling hematopoiesis and regulating immune function, therefore enteral nutrition can be therapeutically relevant strategy to modulate the microbiome and support immune recovery. Given our previous work utilizing murine models of antibiotic induced bone marrow failure, we hypothesize that plant based enteral nutrition will provide superior recovery from antibiotic-induced bone marrow suppression via microbial fermentation of dietary fiber and production of SCFAs compared to widely adopted artificial enteral nutrition.

PI_NAMEs: CHATRIZEH, MONA  (contact)

PROGRAM_OFFICER_NAME: GILLASPY, ALLISON

PROJECT_TERMS: Adopted;Anaerobic Bacteria;Anemia;Animals;Antibiotics;Bone Marrow;Bone marrow failure;Bone Marrow Suppression;Cells;Chronic;Clinical;Clinical Trials;clinically relevant;Critical Care;Critical Illness;cytokine;Data;Development;Diet;Dietary Fiber;Disease Progression;dysbiosis;Emergency Situation;Enteral Nutrition;Equilibrium;experimental study;fecal transplantation;Fermentation;Fiber;Functional disorder;functional outcomes;Genomics;Germ-Free;Goals;graduate student;Growth;gut dysbiosis;gut microbiome;gut microbiota;Hematopoiesis;Hematopoietic stem cells;Immune;immune function;immune health;Immune response;Immune system;Immunity;immunoregulation;Immunosuppression;Impairment;improved;improved outcome;Infection;Laboratories;Lead;Learning;Life;Link;Lymphocyte;Lymphocyte Count;Lymphopenia;Lymphopoiesis;Mediating;Mediator;metabolomics;microbial;microbiome;microbiota;mouse model;Mus;Myelogenous;Myelopoiesis;neglect;neutrophil;Neutrophilia;nutrition;Operative Surgical Procedures;Outcome;Patients;Plants;Play;Population;Preparation;Process;Production;protective effect;Publications;Randomized;Recovery;Reproducibility;Research;Risk;Role;Scientist;secondary infection;Series;Shapes;Surgeon;Testing;Therapeutic;therapeutic target;Volatile Fatty Acids;Vulnerable Populations;Work

PROJECT_TITLE: Microbiome targeted nutrition to improve immune function during critical illness


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services

ORG_CITY: WINSTON-SALEM

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

PHR: PUBLIC HEALTH RELEVANCE A persistent trend exists in the science of health care interventions for older adults; some of what we know works does not get provided in everyday routine health care and some interventions that have no benefit continue to be offered and delivered. In this conference series we will increase awareness of the evidence translation gap; we will use specific case studies in multidisciplinary teams to examine the barriers to implementing research and scaling it broadly, or de-implementing interventions that may be harmful or ineffective. Each conference brings together national leaders, key stakeholders, and promising junior and experienced scientists. The goal is to stimulate new collaborations for implementation research that ultimately improves health and independence in old age.

PI_NAMEs: HIGH, KEVIN P. (contact);WILLIAMSON, JEFF DOUGLAS

PROGRAM_OFFICER_NAME: JOSEPH, LYNDON

PROJECT_TERMS: Acceleration;Address;Administrator;Adopted;Adoption;Age;age related changes;aged;Aging;Alzheimer's Disease;American;Area;Attention;Awareness;Behavior Therapy;bench to bedside;burden of illness;Capsicum;care systems;Caring;Case Study;Clinical;Collaborations;collaborative approach;Complex;cost;Creativeness;Deimplementation;disability burden;Disparity;Dissemination and Implementation;diversity and equity;Education;Equitable healthcare;Equity;evidence base;Evidence based intervention;experience;Failure;Frontline worker;Funding;Geriatrics;Gerontology;Goals;Health;health care service;health care settings;Health Personnel;Health Sciences;Health Services;Health system;Healthcare;healthcare community;Healthcare Systems;Heart Atrium;human old age (65+);implementation intervention;implementation research;implementation science;improved;improved mobility;Independent Living;Individual;innovation;Intervention;Knowledge;Leadership;Learning;Life;medical schools;meetings;Methodology;Modeling;multidisciplinary;older adult;Older Population;Pathway interactions;Patients;payment;Personal Satisfaction;Persons;Policies;Population;population health;Primary Care;Problem Solving;Process;programs;public health relevance;Qualifying;Reduce health disparities;Research;Research Personnel;Science;Scientist;Series;service delivery;symposium;Telephone;Therapeutic;Translating;translational model;Translational Research;Translations;trend;United States National Institutes of Health;Universities;uptake;virtual;webinar;Work;working group

PROJECT_TITLE: Evidence to Impact: Accelerating Implementation of Aging Research

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development for Established Investigators and Conference Grants Study Section[AGCD-4]


NIH_SPENDING_CATS: Neurosciences;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine

ORG_CITY: COLLEGE STATION

ORG_DEPT: CHEMISTRY

ORG_NAME: TEXAS A&M UNIVERSITY

PHR: Project Narrative Glial cell line-derived neurotrophic factor (GDNF) is a growth factor expressed in the nervous system to mediate repair after traumatic injuries. GDNF could therefore be used as a medicine to treat spinal cord injuries. However, that protein has unfavorable properties which may prevent it from becoming a drug or even used as a probe in some cellular experiments; this application is to prepare small molecule GDNF mimics which should be efficacious but void of those detrimental characteristics.

PI_NAMEs: BURGESS, KEVIN  (contact)

PROGRAM_OFFICER_NAME: LAVAUTE, TIMOTHY M

PROJECT_TERMS: 3-Dimensional;Afferent Neurons;Affinity;Agonist;Axon;axon growth;axon guidance;Binding;Biological Assay;Biomedical Engineering;Cell Adhesion Molecules;Cell model;Cells;Cellular Assay;Characteristics;Clinical;Clinical Trials;clinical trials in animals;Communication;Complex;Computing Methodologies;Coupled;Coupling;crosslink;Cues;cytokine;Dangerousness;design;Development;Docking;Engineering;Event;experience;experimental study;extracellular;Family;gene therapy;glial cell-line derived neurotrophic factor;Glycosylphosphatidylinositols;Growth;Growth Factor;Hot Spot;Hyaluronic Acid;improved;In Vitro;in vitro Model;in vivo;innovation;Investigation;Lead;Lecithin;Libraries;Ligand Binding;Ligands;Lipase;Literature;Maleimides;Mediating;Medicine;Membrane Microdomains;Modeling;Molecular Conformation;Motor Neurons;Nerve Regeneration;Nervous System;Nervous System Trauma;Neural Cell Adhesion Molecules;Neurites;neuronal survival;Neurons;neurotensin mimic 2;novel;Nuclear;Peripheral Nervous System;Pharmaceutical Preparations;Phase III Clinical Trials;predictive tools;prevent;professor;Property;Proteins;prototype;receptor;Recovery;repair model;repaired;Reporting;response;Role;Sampling;Series;Serum;Signal Induction;Signal Pathway;Signal Transduction;small molecule;Spinal cord injury;Spinal Ganglia;stem cells;success;Surface;Synapses;Testing;three-dimensional modeling;Time;Tissues;Transfection;Translating;Trauma;Traumatic injury;two-dimensional;Work

PROJECT_TITLE: Mid-sized GDNF Minics for Neural regeneration


NIH_SPENDING_CATS: Aging

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PI_NAMEs: DAVIS, MARK MORRIS (contact)

PROGRAM_OFFICER_NAME: PRABHUDAS, MERCY R

PROJECT_TITLE: Administrative Core


PI_NAMEs: NADEAU, KARI C. (contact)

PROJECT_TITLE: Clinical Core


PI_NAMEs: MAECKER, HOLDEN T. (contact)

PROJECT_TITLE: Human Immune Monitoring Core


PI_NAMEs: SHEN-ORR, SHAI SHLOMO (contact)

PROJECT_TITLE: The effects of immune-age on immune-response and the molecular mechanisms which drive it


PROJECT_TITLE: Molecular interception and immunological characterization of age-associated disease


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_CITY: BOSTON

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: HARVARD MEDICAL SCHOOL

ORG_STATE: MA

PHR: Project Narrative: The identification and classification of the genome is an essential foundation for understanding human physiology. This work will explore the remaining uncharted corners of the genome that are activated during inflammation. By discovering the functions of these unknown regulators of immunity, we hope to uncover novel mechanisms underpinning all human disease and identify new therapeutic targets never before investigated.

PI_NAMEs: JACKSON, RUAIDHRI  (contact)

PROGRAM_OFFICER_NAME: VAZQUEZ-MALDONADO, NANCY

PROJECT_TERMS: Acceleration;Adherence;Animal Model;Biological Process;Categories;Chimeric Proteins;Classification;Code;dark matter;differential expression;Disease;Event;Foundations;gain of function;Gene Silencing;Genes;Genome;genome-wide;Genomics;Human;human disease;Immune response;Immune system;Immunity;Inflammation;Inflammatory Response;innovative technologies;Investigation;knock-down;loss of function;Macrophage;mammalian genome;Messenger RNA;new therapeutic target;novel;Open Reading Frames;Physiological;Physiology;Process;Protein Biosynthesis;Proteins;Resolution;ribosome profiling;RNA;RNA Splicing;Role;screening;Technology;Testing;Trans-Splicing;Transcript;transcriptomics;Translations;translatome;Untranslated RNA;Work

PROJECT_TITLE: Illuminating the immune system's genomic dark matter: functionally annotating the hidden translatome


ORG_NAME: WASHINGTON UNIVERSITY

PHR: Project Narrative: The COVID-19 pandemic has demonstrated the immense risk posed by the emergence of novel viral strains. There is an urgent need to develop new vaccination approaches to induce broadly protective immunity against highly mutable mucosal viruses, which are likely sources of future pandemics. In this proposal, I will explore how the tissue microenvironment shapes the development of memory B cells following viral infection in order to better understand how vaccines can enhance the antiviral memory B cell response and establish broadly protective immunity against mucosal viruses.

PI_NAMEs: LAIDLAW, BRIAN  (contact)

PROGRAM_OFFICER_NAME: CASTLEMAN, MORIAH JOVITA

PROJECT_TERMS: Affinity;Antibody Response;Antigens;B-Cell Antigen Receptor;B-Cell Development;B-Lymphocytes;Cells;COVID-19 pandemic;cross reactivity;Cues;design;Development;Exposure to;future pandemic;Gene Expression Profile;Genetic Transcription;Immunity;Immunoglobulin-Secreting Cells;Infection;Influenza;insight;Lung;Lymphocyte;Mediating;Memory;Memory B-Lymphocyte;Mucous Membrane;Mutate;Mutation;novel;novel strategies;Pathway interactions;response;Risk;Shapes;Source;Tissues;Vaccination;vaccination strategy;Vaccine Design;vaccine development;Vaccines;Viral;Viral Antigens;Virus;Virus Diseases

PROJECT_TITLE: Enhancing the antiviral memory B cell response


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Biotechnology;Immunotherapy;Organ Transplantation;Pediatric;Regenerative Medicine;Transplantation;Women's Health Research

ORG_CITY: TEMPE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

ORG_STATE: AZ

PHR: Project Narrative The proposed research is relevant to public health because it aims to develop a method to transplant cells and tissue in the absence of chronic systemic immunosuppression, which could lead to improved outcomes in the general population of transplant recipients. This project is relevant to NIH’s mission, as the development of methods to transplant cells and tissue in the absence of immunosuppression would impact tens of thousands of transplant recipients per year.

PI_NAMEs: WEAVER, JESSICA DIANE (contact)

PROGRAM_OFFICER_NAME: KULKARNI, SHILPA S

PROJECT_TERMS: Allogenic;Antigen-Presenting Cells;Antigens;Area;Cell Therapy;Cell Transplantation;Cells;Chronic;Clinical;Conceptus;Development;Engineering;exhaust;Fetus;General Population;Goals;Graft Survival;Homologous Transplantation;Hydrogels;Immune response;Immune Tolerance;Immunology;immunoregulation;Immunosuppression;implantation;improved outcome;In Vitro;in vivo;Infection;Maintenance;Malignant Neoplasms;Mesenchymal Stem Cells;method development;Methods;mimicry;Mission;Mothers;Organ;organoid transplantation;Organoids;Phenotype;Physiological;Placenta;Pregnancy;Public Health;Regimen;Regulatory T-Lymphocyte;Research;Risk;Role;side effect;Tissue Transplantation;Tissues;Transplant Recipients;Transplantation;Transplantation Immunology;trophoblast;United States National Institutes of Health;Vaccines

PROJECT_TITLE: Immunosuppression-free transplantation through placental mimicry


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Clinical Research;Health Services;Women's Health Research

ORG_NAME: TUFTS UNIVERSITY BOSTON

PHR: There is an urgent need to train investigators with an understanding of how to conduct research to understand the sex/gender differences in basic disease mechanisms and to understand the heterogeneity of treatment effects by sex/gender in devices, drugs, and other treatments. By harnessing the incredible talent and leveraging the unique resources of the Tufts community, Dr. Freund and Dr. Jaffe have developed and further expanded the Tufts University BIRCWH Scholars Program. This tailored training program for Early Career Investigators focuses on sex and gender differences and women's health research and ensures the training of a cadre of investigators to become the future research leaders in this critical area.

PI_NAMEs: FREUND, KAREN  (contact);JAFFE, IRIS Z

PROGRAM_OFFICER_NAME: TIGNO, XENIA

PROJECT_TERMS: Address;Applications Grants;Appointment;Basic Science;cardiovascular health;career;Caring;Clinical;Clinical Research;Clinical Services;Disease;disorder prevention;early-career faculty;Faculty;Funding;gender difference;Goals;graduate school;health equity;Health Services Research;Heterogeneity;Interdisciplinary Study;Life Cycle Stages;Maternal Health;Mentors;Modeling;next generation;Nutritional Science;Outcome;Outcomes Research;Positioning Attribute;Preparation;programs;recruit;Research;Research Personnel;Research Project Grants;Research Training;Scholars Program;Science;sex;Sex Differences;skill acquisition;Training;Translational Research;treatment effect;Universities;Woman;Women's Health

PROJECT_TITLE: Supporting the Tufts BIRCWH Program with an Additional Scholar Position


NIH_SPENDING_CATS: Congenital Structural Anomalies;Genetics;Hematology;Pediatric;Primary Immunodeficiencies;Rare Diseases

ORG_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

PI_NAMEs: CROUCH, ROBERT J (contact)

PROJECT_TERMS: Accounting;Affect;Alternative Splicing;Amino Acids;Appearance;B-Cell Development;Bacteria;Biochemical;Birth;Bite;Blood Transfusion;Breeding;Catalytic Domain;Cell Maintenance;Cell Nucleus;Cell Physiology;Cells;Chemicals;Codon Nucleotides;Defect;Development;Diamond-Blackfan anemia;Disease;disease classification;disease model;DNA;DNA biosynthesis;DNA Damage;DNA Repair;DNA Sequence;DNA Sequence Alteration;DNA-Directed DNA Polymerase;drinking water;Drug Targeting;ds-DNA;Elements;Embryo;Embryonic Development;embryonic stem cell;enzyme activity;Enzymes;Epigenetic Process;Escherichia coli;Exclusion;Exhibits;exosome;Failure;feeding;Frequencies;Gene Proteins;Generations;Genes;Genetic Transcription;Genome;Genome Stability;Genomic Instability;Glycine;Goals;HIV;HIV/AIDS;Housekeeping Gene;Human;human model;Hybrids;Hydrolysis;improved;in vivo;insight;Knockout Mice;Leucine;Location;Malnutrition;Mediating;melanocyte;Messenger RNA;Mitochondria;Mitochondrial DNA;Mitochondrial Myopathies;Mitochondrial RNA;Modeling;mouse model;Mus;mutant;Mutate;Mutation;N-terminal;Nature;Neural Crest;Neurologic;NOR Mouse;Nuclear;Nutrient;nutrition;Nutritional status;offspring;Paper;particle;Pathway interactions;Patients;Perinatal mortality demographics;Pharmaceutical Preparations;Phenotype;prevent;Process;Production;Property;Protein Biosynthesis;Proteins;pseudotoxoplasmosis syndrome;pup;Reaction;Reporting;response;Retroviridae;Ribonuclease H;ribonuclease H1;Ribonucleases;Ribonucleotides;Ribosomal DNA;Ribosomal Proteins;Ribosomes;ribosomopathy;RNA;RNA primers;RNA Splicing;Role;Scanning;Serine;Site;Small Nucleolar RNA;Spottings;Stimulator of Interferon Genes;Structure;Suggestion;Surgical incisions;Symptoms;Syndrome;Testing;Time;Transcription Initiation;transcription termination;transcriptome sequencing;Translating;Translation Initiation;Type I Interferonopathy;Untranslated RNA;Variant;Viral;viral RNA;Virus;Virus Replication;White Spots;Yeast Model System

PROJECT_TITLE: Factors Influencing Genetic Transcription Initiation And Termination


PI_NAMEs: LEVIN, HENRY L. (contact)

PROJECT_TERMS: Address;Aging;Alleles;Amyotrophic Lateral Sclerosis;Anti-Retroviral Agents;Antibodies;Binding;Binding Sites;Brain;brain tissue;Catalogs;causal variant;Cell Nucleus;Cell Physiology;Cells;Cerebellum;ChIP-seq;Chromatin;chromatin immunoprecipitation;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Complex;Dana-Farber Cancer Institute;Data;Data Set;Databases;density;Disease;Disparity;DNA Insertion Elements;DNA Polymerase II;DNA Transposable Elements;Drug resistance;Elements;Enhancers;env Gene Products;epigenomics;Event;Family;Fission Yeast;Gene Expression;gene network;gene regulatory network;Genes;Genetic Diseases;Genetic Transcription;genetic variant;Genetic Variation;Genome;genome wide association study;genome-wide;genomic locus;Genomics;Genotype-Tissue Expression Project;Goals;Health;Heat-Shock Response;Hippocampus;histone modification;HIV-1;HIV/AIDS;Human;human disease;Human Genome;human population study;human subject;Hypoxia;in vivo;Individual;integration site;Link;Linkage Disequilibrium;Long Interspersed Elements;Long Terminal Repeats;Luciferases;Maps;Measures;Mediating;Mental disorders;Methods;Methyltransferase;Microtubules;Migraine;Minority Groups;model organism;Modeling;Molecular;National Human Genome Research Institute;Nerve Degeneration;nerve stem cell;Nervous System Disorder;Neurites;Parkinson Disease;particle;pathogen;Pathway interactions;Pattern;Pharmaceutical Preparations;Play;Positioning Attribute;Predisposition;promoter;Promoter Regions;PWWP Domain;Quantitative Trait Loci;recruit;Regulation;Regulatory Element;Reporter Genes;Reporting;Reproducibility;Resolution;response;Retroelements;Retrotransposon;Retroviridae;Reverse Transcription;Risk;RNA;Role;Schizophrenia;Shapes;Short Interspersed Nucleotide Elements;Single Nucleotide Polymorphism;Source;Stress;Study models;System;Testing;Tissue-Specific Gene Expression;Tissues;trait;Trans-Activators;transcription factor;Transcription Initiation Site;transcriptional coactivator p75;transcriptome;transcriptome sequencing;Tubulin;tumor;tyrosyltubulin ligase;United States National Institutes of Health;Variant;Viral;Work;Yeasts

PROJECT_TITLE: Regulation And Function Of Retroelements