ADMINISTERING_IC: TR

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Cerebrovascular;Clinical Research;Immunotherapy;Neurosciences;Orphan Drug;Rare Diseases;Stroke

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: Project Narrative Disorders of the brain remain an enormous medical challenge and new platforms that serve as functional bridges between cell-assays and animal testing are needed to improve our understanding of the disease and to develop and translate therapeutic approaches towards human patient trials. In this proposal, our interdisciplinary team from three CTSA Program hubs (UNC, Duke, and U. of Florida) seek to advance discovery and translation of therapies for brain disorders by further developing the organotypic brain slice (OBSC) platform. Using our OBSC models of neurodegenerative disease, brain cancer, and stroke, we will develop new technological innovations to add disease-relevant capabilities to the platform, screen therapeutic agents to develop better treatment options, and enable immune-based approaches to target new aspects of disease, all with the goal of advancing accessibility of the novel OBSC model and improving the outcomes of patients suffering from brain disorders.

PI_NAMEs: BALDWIN, ALBERT SIDNEY;FLORES, CATHERINE T;FLOYD, SCOTT R;HINGTGEN, SHAWN  (contact)

PROGRAM_OFFICER_NAME: BOUGH, KRISTOPHER J

PROJECT_TERMS: Acceleration;Aftercare;Alzheimer's Disease;Alzheimer's disease model;animal efficacy;Animal Model;Animal Testing;anti-cancer;Area;Biological Assay;Biopsy;Biopsy Specimen;Brain;Brain Diseases;brain disorder therapy;Brain Ischemia;Brain Neoplasms;Brain Pathology;brain tissue;Cancer Model;Cell Death;Cell Therapy;Cells;Cellular Assay;Cellular immunotherapy;Chemicals;chimeric antigen receptor T cells;Clinical;clinical efficacy;Clinical Research;Collaborations;Communities;cost;Development;Discipline;Disease;disease model;Disease Progression;DNA lesion;drug development;drug discovery;Drug Screening;Effectiveness;efficacy study;experience;extracellular;Florida;Foundations;gene gun;gene therapy;Genes;Genomics;Glioblastoma;Goals;Grant;Heterogeneity;Human;Huntington Disease;I-kappa B Proteins;Immune;Immunotherapy;improved;improved outcome;Individual;Infarction;Inflammatory;Infrastructure;innovation;Institution;Ischemia;Ischemic Stroke;knock-down;Laboratories;Malignant neoplasm of brain;Malignant Neoplasms;Mediating;Medical;member;Methods;Microglia;Modeling;Molecular;molecular imaging;mouse model;multidisciplinary;Nervous System Disorder;Neurodegenerative Disorders;Neurologic;Neurological Models;new technology;next generation;novel;novel therapeutics;optical imaging;Parkinson Disease;Pathway interactions;Patient Care;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;prevent;Process;Program Development;programs;real time monitoring;Reporter;Research;Resources;Role;screening;Series;Signal Pathway;Signal Transduction;Slice;Small Interfering RNA;small molecule;stem cell therapy;Stroke;Structure;synergism;System;Techniques;technological innovation;Technology;Testing;Therapeutic;Therapeutic Agents;therapeutically effective;Time;Tissues;tool;Transfection;Translating;Translation Initiation;translational therapeutics;Translations;treatment response;tumor heterogeneity;Viral

PROJECT_TITLE: A consortium effort to translate therapies for neurological diseases via an ex vivo organotypic platform


ADMINISTERING_IC: EY

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL EYE INSTITUTE

ORG_CITY: LOS ANGELES

ORG_COUNTRY: UNITED STATES

ORG_DEPT: OPHTHALMOLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: Overall Core Component Project Narrative The proposed core facilities will continue to provide essential support for the activities of vision researchers in at UCLA. Thus, the core provides equipment and technical skills to support research on the visual system and its disorders, and to foster collaborations in these endeavors.

PI_NAMEs: WILLIAMS, DAVID S (contact)

PROGRAM_OFFICER_NAME: GOVER, TONY DOUGLAS

PROJECT_TERMS: Back;Biochemistry;Cells;Collaborations;Contract Services;Core Facility;Core Grant;cost;Disease;Equipment;Evaluation;Extramural Activities;Eye;Faculty;Fostering;Funding;Genes;Goals;Grant;Human Resources;Image;Image Analysis;Individual;Infrastructure;Institution;instrument;instrumentation;investigator training;Knowledge;Laboratories;medical schools;member;Microscopy;Molecular Biology;Postdoctoral Fellow;Productivity;prototype;Recording of previous events;recruit;Research;Research Activity;Research Personnel;Research Support;Scientist;skills;Software Engineering;Students;success;Talents;Technical Expertise;Training;Vision;Vision research;Visual System

PROJECT_TITLE: Vision Research Core at UCLA


ADMINISTERING_IC: CA

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Hematology;Orphan Drug;Radiation Oncology;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: PROJECT NARRATIVE Because blood cancers are exquisitely sensitive to radiation, targeted radiation delivery via radioimmunotherapy (radionuclides stably linked to target-specific antibodies) has gained interest with a commensurate increase in radioimmunotherapy clinical trials. Although clinical efficacy has been observed in stand-alone radioimmunotherapy for cancers, or as part of conditioning regimens prior to allogeneic hematopoietic stem cell transplantation, how the normal bone marrow niche differentially responds radioimmunotherapy compared to conventional approaches is not well-understood, limiting potential interventions to mitigate the negative effects from radiation to the marrow. This proposal will address current limitations and identify how to modulate specific bone marrow niche alterations for desired clinical goals by identifying how the hematopoietic stem cells, vascular endothelial cells and stromal cells in the bone marrow niche respond to radioimmunotherapy with an alpha- emitter (astatine-211), beta-emitter (yttrium-90), or X-ray radiation, as gauged by stem cell functional assays, architecture restructuring using microscopy, and differential gene expression from RNA sequence analysis.

PI_NAMEs: OROZCO, JOHNNIE JOSE (contact);TERMINI, CHRISTINA MARIE

PROGRAM_OFFICER_NAME: CAPALA, JACEK

PROJECT_TERMS: 3-Dimensional;90Y;Acceleration;Acute leukemia;Address;Allogenic;Antibodies;Architecture;Area;Astatine;Bioinformatics;Biological Assay;Blood;Blood Platelets;Blood Vessels;Bone Marrow;Bone Marrow Cells;Bone Marrow Stem Cell Transplantation;cadherin 5;Cancer Patient;cancer radioimmunotherapy;cancer therapy;Cell Compartmentation;Cell surface;Cells;Cessation of life;Characteristics;Chemotherapy and/or radiation;Clinical;clinical efficacy;Clinical Trials;conditioning;confocal imaging;Confocal Microscopy;Coupled;Data;Diameter;Endothelial Cells;Erythrocytes;experimental study;Exposure to;Femur;fibroglycan;Flow Cytometry;Frequencies;Future;Gene Expression Profile;Genetic Transcription;Goals;Grant;Half-Life;Harvest;Hematologic Neoplasms;Hematology;Hematopoiesis;Hematopoietic;Hematopoietic Neoplasms;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;Hour;Image;improved;in vivo;interest;Intervention;irradiation;Knowledge;Length;leptin receptor;leukemia;Leukocytes;Link;Maps;Marrow;Measures;microscopic imaging;Microscopy;Molecular;Multiple Myeloma;Mus;Myelogenous;Natural regeneration;new therapeutic target;Organ;Outcome;Pathway interactions;Patient-Focused Outcomes;Patients;PECAM1 gene;Perfusion;physical model;Population;Proliferating;Provider;PTPRC gene;Radiation;radiation delivery;radiation effect;Radiation exposure;Radiation Injuries;Radiation therapy;Radiation Toxicity;Radioactive Elements;Radioimmunotherapy;Radioisotopes;Radionuclide therapy;Recovery;Regimen;repaired;Reporting;Residual state;response;Risk;RNA Sequence Analysis;Roentgen Rays;Role;self renewing cell;self-renewal;Signal Transduction;Source;stem cell function;stem cell proliferation;stem cells;Stromal Cells;Structure;Supporting Cell;Surface;System;Systemic Therapy;Technology;Thick;Time;Tissue-Specific Gene Expression;tool;Toxic effect;Traction;transcriptome sequencing;Transplantation;Vascular Endothelial Cell;x-ray irradiation

PROJECT_TITLE: Selective Radionuclide Delivery for Precise Bone Marrow Niche Alterations

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Bioengineering;Eye Disease and Disorders of Vision;Networking and Information Technology R&D (NITRD)

PROJECT_TERMS: 3-Dimensional;Basic Science;California;Cells;Complement;Computer software;Computers;Confocal Microscopy;Core Facility;Dedications;Electron Microscope;Electron Microscopy;Electrons;Equipment;Eye;Image;Image Analysis;imaging capabilities;imaging facilities;Individual;innovation;Label;Laboratories;Laboratory Research;Licensing;Light;light microscopy;live cell imaging;member;Methods;Microscope;microscopic imaging;Microscopy;nanoscience;nanosystems;open source;Organoids;pre-clinical research;Preparation;preservation;Recording of previous events;Research Support;Running;Sampling;Scanning;skills;Spectrum Analysis;superresolution microscopy;Technical Expertise;Thick;Tissue Preservation;Tissues;tomography;Training;ultra high resolution;United States National Institutes of Health;Vision research

PROJECT_TITLE: Microscopy and Imaging Analysis Core


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Eye Disease and Disorders of Vision;Neurosciences

PI_NAMEs: NUSINOWITZ, STEVEN  (contact)

PROJECT_TERMS: adaptive optics;Aging;Algorithmic Software;angiogenesis;Angiography;Animal Model;Animals;Anterior;Applications Grants;Behavior;behavior test;Behavioral;Behavioral Paradigm;Biological Assay;Biological Markers;Complement;Consultations;Contrast Sensitivity;Core Grant;cost;Custom;Data;Data Analyses;Detection;Development;Disease;disease natural history;Electrophysiology (science);Electroretinography;Emerging Technologies;Engineering;Equipment;Evaluation;experience;experimental study;Eye;Eye diseases;feasibility research;fluorescence imaging;Fostering;Funding;fundus imaging;Future;Goals;Grant;Growth;Hospitals;Image;imaging capabilities;in vivo;in vivo imaging;Individual;instrumentation;interest;Intervention;Joints;Laboratories;Laboratory Research;Life;Light;Measurement;Methodology;Methods;Modality;Modification;Monitor;Motion;mouse model;Mouse Strains;Mus;Mutant Strains Mice;new technology;non-invasive imaging;novel;Optical Coherence Tomography;Optics;Pathogenicity;Pattern;pharmacologic;Phenotype;Postdoctoral Fellow;Process;programs;Psychophysics;recruit;Reflex action;Research;Research Design;Research Personnel;Research Project Grants;research study;Resolution;Resources;response;Retina;Retinal Degeneration;retinal imaging;Rodent;Services;skills;small molecule;Specialist;stem cells;Structure;Swimming;System;Technology;Testing;Time;timeline;Training;Translational Research;Update;Vertebrate Photoreceptors;Viral Vector;Vision;Vision research;vision science;Visual;Visual Acuity;Visual evoked cortical potential;Visual Pathways;visual performance;Work

PROJECT_TITLE: Live Imaging and Functional Evaluation Core


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Disorders;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Neurosciences;Serious Mental Illness

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: Narrative The project will focus on developing a new software strategy enabling collaborative studies that apply diffusion MRI to investigate the human brain. The software will be easy to deploy and will automatize dMRI processing and quality check with a user-friendly dashboard. Upon the development of our software strategy, it will be easier for clinical centers to join decentralized studies, increasing the ability of such studies to identify subtle neurological changes.

PI_NAMEs: CHO, KANG IK  (contact)

PROGRAM_OFFICER_NAME: DUAN, QI

PROJECT_TERMS: Address;Antisocial Personality Disorder;autism spectrum disorder;automated analysis;Automatic Data Processing;Automation;Back;Bipolar Disorder;Brain;Brain Diseases;clinical center;clinical research site;Collaborations;computer infrastructure;computer science;Computer software;computerized data processing;Conduct Disorder;Consumption;dashboard;Data;Data Collection;data collection site;data dashboard;Data Pooling;Data Protection;data quality;Data Security;Data Set;Decentralization;Dependence;design;Development;Diffusion Magnetic Resonance Imaging;Digital Imaging and Communications in Medicine;Disease;Electronic Mail;Epilepsy;Etiology;experience;Genetic;Goals;Heterogeneity;Human;image processing;improved;in vivo imaging;Information Protection;Infrastructure;innovation;Instruction;interest;Internet;Intervention;Intuition;Investigation;Knowledge;Link;Major Depressive Disorder;Manuals;Measures;Meta-Analysis;Methodology;Methods;Monitor;Nature;Nervous System Disorder;neuroimaging;Neurologic;Operating System;operation;Outcome;Outcome Measure;Output;Pathologic;Personally Identifiable Information;Post-Traumatic Stress Disorders;Process;Quality Control;Reporting;Reproducibility;Research;Resources;response;Running;Sample Size;Schizophrenia;Scientist;Seminal;Site;skills;Sleep;Sleeplessness;Software Tools;Statistical Data Interpretation;Structure;System;Techniques;Time;tool;user-friendly;Visualization;web server;white matter;white matter change

PROJECT_TITLE: User-friendly Analysis Platform for Decentralized Multi-site Diffusion MRI Studies

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]


NIH_SPENDING_CATS: Biotechnology;Eye Disease and Disorders of Vision;Gene Therapy;Genetics;Neurosciences

PI_NAMEs: YANG, XIAN-JIE  (contact)

PROJECT_TERMS: adeno-associated viral vector;Adult;animal facility;Animal Model;Applications Grants;Basic Science;Cell Culture Techniques;Cells;Collaborations;Containment;Core Grant;Data;design;Educational process of instructing;Equipment;experience;Funding;Gene Delivery;Genes;genetic manipulation;Goals;Harvest;human stem cell-derived;Individual;Injections;innovation;instrument;Laboratories;Lentivirus;Lentivirus Vector;member;micromanipulator;Microscope;Molecular Biology;Mus;nanoparticle;Neonatal;Nucleic Acids;Postoperative Period;pre-clinical;pre-clinical research;Preclinical Testing;Preparation;Procedures;Production;Proteins;Reagent;Recombinant adeno-associated virus (rAAV);recombinant viral vector;recombinant virus;Research;Research Personnel;Research Support;response;Retina;Rodent;Scientist;small molecule;Supervision;targeted delivery;Testing;therapeutic evaluation;Tissues;tool;Transfection;United States National Institutes of Health;Vertebral column;Viral;Viral Vector;Vision;Vision research;vision science;web site

PROJECT_TITLE: Gene and Cell Delivery Core


ADMINISTERING_IC: OD

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

ORG_CITY: CHAMPAIGN

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

ORG_STATE: IL

PHR: Project Narrative This program will train veterinary students in biomedical research methods and promote their development as veterinarian scientists. Training future generations of veterinarian scientists is essential for advancing society’s understanding of the biomedical sciences and promoting public health.

PI_NAMEs: FLAWS, JODI A.;MAHONEY, MEGAN M (contact)

PROGRAM_OFFICER_NAME: TANDON, RITESH

PROJECT_TITLE: Summer Training in Translational Biomedical Research


NIH_SPENDING_CATS: Bioengineering;Eye Disease and Disorders of Vision;Genetics

PI_NAMEs: RADU, ROXANA A (contact)

PROJECT_TERMS: Acceleration;Biochemical;Biochemistry;Biological;Biological Assay;Cells;Circular Dichroism;Circular Dichroism Spectroscopy;Collaborations;cost;Data;digital;DNA;DNA analysis;Elasticity;Equipment;Faculty Recruitment;Fluorescence;Fourier Transform;Future Teacher;Gene Expression Profile;Genes;Goals;Human Resources;Immunoassay;Incubators;Individual;Infrastructure;instrument;instrumentation;Laboratories;light scattering;luminescence;meetings;Microfluidics;Molecular;Molecular Biology;next generation;Polymerase Chain Reaction;Preparation;Productivity;programs;protein function;Proteins;Reaction;Reader;recruit;Research;Research Personnel;Resolution;Resources;RNA;RNA analysis;Sampling;scale up;Services;single-cell RNA sequencing;Specimen;Spectrophotometry;Spectrum Analysis;Students;System;Technology;Time;Tissues;Training;Vision research;Western Blotting;Work

PROJECT_TITLE: Biochemistry & Molecular Biology  Instrumentation Core


PI_NAMEs: GLASGOW, BEN J (contact)

PROJECT_TITLE: Prototype Construction Core


PI_NAMEs: HUBBELL, WAYNE L (contact)

PROJECT_TERMS: Algorithms;Architecture;Area;Basic Science;Career Choice;Certification;Clinical Research;Code;computer program;Computer software;Computers;Core Facility;Custom;Data Analyses;design;Development;Devices;Documentation;Education;Educational process of instructing;Electrophysiology (science);Endowment;Environment;experience;Eye;Fostering;Grant;Home;Human Resources;Improve Access;innovation;instrument;instrumentation;Laboratories;Learning;mathematical analysis;Mechanics;member;Modernization;Mus;Optics;Output;Performance;Play;Positioning Attribute;Programming Languages;programs;Reading;Real-Time Systems;Research;Research Personnel;Running;Schedule;sensor;skills;software development;Software Engineering;Software Tools;Speed;Students;symposium;System;Technology;Testing;Text;Time;Training;virtual;Vision research;voltage;Writing

PROJECT_TITLE: Software Engineering Core


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Autoimmune Disease;Biotechnology;Clinical Research;Lung;Organ Transplantation;Rare Diseases;Transplantation

ORG_CITY: CHICAGO

ORG_DEPT: SURGERY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: Primary graft dysfunction (PGD) is a deadly complication following lung transplantation affecting over 50% of recipients. While PGD has been traditionally thought to be due to ischemia-reperfusion injury, we have discovered that transplant recipients have high incidence of pre-existing lung autoantibodies which react with the newly transplanted lung causing severe damage which presents as PGD. In the prior funding cycle, we identified novel pathways through which the pre-existing autoantibodies cause damage to the transplanted lung. In the next cycle, we will identify clinically actionable treatments to protect the transplant recipients against the damaging effects of these autoantibodies.

PI_NAMEs: BHARAT, ANKIT  (contact);BUDINGER, GR SCOTT

PROGRAM_OFFICER_NAME: MONGODIN, EMMANUEL FRANCK

PROJECT_TERMS: Acute Respiratory Distress Syndrome;Affect;allograft rejection;Allografting;Alveolar;Alveolar Macrophages;Antibodies;Antigen-Antibody Complex;Antigens;Autoantibodies;Autoantibody binding;Autoantigens;Award;Binding;Biological Assay;Cells;Chronic;Chronic lung disease;Clinical;clinical application;Clinical Research;clinically actionable;Collagen Type V;Complement;Complement Activation;Complication;conditional knockout;COVID-19;CXCL2 gene;cytokine;Data;Development;end stage disease;Endothelium;Epitopes;Extracellular Matrix Proteins;Extravasation;Fc Receptor;Flow Cytometry;Functional disorder;Funding;Gene Modified;graft dysfunction;High Prevalence;Hour;Human;Image;Immune;immunogenic;improved;Incidence;Industry Collaboration;insight;Knockout Mice;Life;Ligation;Link;Lung;lung allograft;lung injury;Lung Transplantation;Matrix Metalloproteinases;Mediating;migration;Molecular;monocyte;mortality;mouse model;Mus;Mutate;neutrophil;Neutrophil Collagenase;Neutrophil Infiltration;novel;Organ;Organ Transplantation;Outcome;Pathogenesis;Pathway interactions;Patient Care;Patients;Pattern;Perfusion;Permeability;PIK3CG gene;Postoperative Period;Production;prospective;Publishing;Reaction;reconstitution;recruit;Reperfusion Injury;response;Risk;Role;Severities;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Solid;Spleen;Testing;TLR2 gene;Translating;Transplant Recipients;Transplantation;Tubulin;two-photon;Variant;Vascularization;Work

PROJECT_TITLE: Pathogenesis of lung injury mediated by lung-restricted antibodies

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CVRS-B(03)]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: PROJECT NARRATIVE The molecular composition of a cell’s surface dictates how cells communicate, interact with their environment, and is the physical platform for certain diagnostic and therapeutic modalities. Our discovery of cell surface glycoRNAs changes the view of what types of biomolecules can exist on the cell surface to regulate critical aspects of cell biology. This proposal aims to significantly advance our ability to study glycoRNAs through chemical tool development, elucidate the molecular context of cell surface glycoRNA, and expand our view on the scope of species that can produce glycoRNA conjugates.

PI_NAMEs: FLYNN, RYAN ALEXANDER (contact)

PROGRAM_OFFICER_NAME: BOND, MICHELLE RUEFFER

PROJECT_TERMS: Anabolism;Biochemical;Biogenesis;Biological Assay;Biology;Biophysics;Caenorhabditis elegans;Carbohydrates;Carboxylic Acids;Cell Communication;Cell model;Cell Physiology;Cell surface;cell type;Cells;Cellular biology;Chemicals;Communities;Complex;Diagnostic;Dissection;Engineering;Environment;Eukaryota;Exclusion;field study;Fission Yeast;Genetic;Glycobiology;glycosylation;Hybrids;Image;immunoregulation;innovation;Intracellular Space;Label;Link;Mammalian Cell;Metabolic;Methods;Modality;Molecular;Nature;Neighborhoods;novel;novel strategies;Organism;pathogen;Pathogenicity;Pathway interactions;Play;Polymers;Polysaccharides;Positioning Attribute;Prokaryotic Cells;receptor;Receptor Signaling;Regulation;Reporter;RNA;Role;Saccharomyces cerevisiae;sialic acid binding Ig-like lectin;Signal Transduction;Surface;Therapeutic;Therapeutic Intervention;tool;tool development;Work;Yeasts

PROJECT_TITLE: Mechanisms and functions of cell surface glycoRNAs


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Biotechnology;Cancer;Childhood Leukemia;Genetics;Hematology;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: MEMPHIS

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

ORG_STATE: TN

PHR: PROJECT NARRATIVE Oncogenic gene fusions involving Nucleoporin 98 (NUP98) are recurrent in pediatric acute myeloid leukemia (AML) and are associated with poor patient outcomes. NUP98 fusion oncoproteins localize within the nucleus in membrane-less organelles, or “puncta”, that are necessary for cell transformation and deregulated gene expression, and the studies proposed here will interrogate the composition of NUP98 FO-associated puncta and their potential for therapeutic targeting. By identifying which members of the NUP98 FO interactome are functionally important and determining if puncta disruption is necessary for therapeutic benefit, this research plan may identify new therapeutic approaches for high-risk, NUP98-rearranged AMLs.

PI_NAMEs: MICHMERHUIZEN, NICOLE  (contact)

PROGRAM_OFFICER_NAME: SCHMIDT, MICHAEL K

PROJECT_TERMS: Acute Myelocytic Leukemia;Address;Binding;Bioinformatics;Biological Assay;Bone Marrow Transplantation;C-terminal;career;Cell Death;cell growth;Cell Nucleus;Cell Survival;cell transformation;Cells;Childhood Acute Myeloid Leukemia;Childhood Leukemia;chimeric gene;Chromatin;chromatin remodeling;Chromatin Structure;Chromosomal Rearrangement;Chromosomal translocation;Colony-forming units;Complex;CRISPR screen;CRISPR/Cas technology;Data;Data Set;design;Developmental Gene;Disadvantaged;Disease;DNA Binding;drug efficacy;effective therapy;Epigenetic Process;epigenomics;experimental study;exportin 1 protein;fitness;functional genomics;Fusion Oncogene Proteins;Gene Expression;Gene Expression Profile;Gene Expression Regulation;Gene Fusion;Genes;Goals;Guide RNA;Hematopoietic;Hematopoietic stem cells;high risk;Histone Acetylation;histone acetyltransferase;homeodomain;HOXA9 gene;Immunoprecipitation;In Vitro;in vivo;Investigation;Lead;leukemia;leukemogenesis;Libraries;Liquid substance;Lysine;Malignant - descriptor;Malignant Neoplasms;Mass Spectrum Analysis;Mediating;Mediator;member;Membrane;MLL gene;Modeling;mouse model;Mus;N-terminal;novel;novel therapeutic intervention;Nuclear Pore Complex Proteins;nucleocytoplasmic transport;Oncogene Deregulation;Oncogenic;Organelles;Outcome;Patient-Focused Outcomes;pharmacologic;Pharmacology;Phase;Phenotype;post-doctoral training;pre-doctoral;promoter;Property;Proteins;quantitative imaging;Reader;Recurrence;Research;Research Proposals;Role;Saint Jude Children's Research Hospital;Scientist;self-renewal;small molecule;small molecule inhibitor;stemness;structural biology;targeted treatment;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;therapeutically effective;therapy resistant;Time;Training;Transcriptional Regulation;Validation

PROJECT_TITLE: Functional and Pharmacologic Investigation of the NUP98 Fusion Oncoprotein Interactome

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Transition to Independence Study Section (I)[NCI-I]


PHR: Extremely high rates (>50%) of primary graft dysfunction (PGD) due to ischemia reperfusion injury (IRI) are the predominant cause of impaired post-lung transplant outcomes resulting in both short-term mortality as well as chronic lung allograft rejection. In the prior funding cycle, we developed state-of-the-art research tools and complex murine models of sequential spleen and lung transplantation to unravel a fascinating multicellular signaling complex led by recipient classical monocytes primed in the spleen that was responsible for the pathogenesis of PGD. In the next funding cycle, we will use complementary genetic and pharmacological techniques to identify the mechanisms through which classical monocytes are activated after reaching the transplanted lung as well as those that result in the recruitment and priming of classical monocytes in the spleen while generating a molecular atlas of PGD to facilitate rapid clinical translation.

PROJECT_TERMS: Affect;allograft rejection;Allografting;Alveolar;Alveolar Macrophages;Atlases;Biology;Bone Marrow;CCL2 gene;Cells;chemokine;Chronic;Clinical;clinical application;clinical practice;clinical translation;clinically relevant;Complex;Credentialing;Data;Donor person;Down-Regulation;Endothelium;Experimental Designs;experimental study;Extravasation;fascinate;Funding;Genetic;Genetic study;graft dysfunction;Herpes zoster disease;Hour;Human;human tissue;Hypoxemic Respiratory Failure;Image;Immune;Impairment;Inflammasome;Injury;Interleukin-1 beta;intravital imaging;Laboratories;Lung;lung allograft;lung injury;Lung Transplantation;Macrophage;Mediating;migration;Modeling;Molecular;monocyte;mortality;mouse model;Mus;Mutate;neutrophil;Neutrophil Infiltration;novel;Organ;Outcome;pathogen;Pathogenesis;Pathway interactions;Patients;Permeability;pharmacologic;Process;Proteins;Publishing;Pulmonary Inflammation;receptor;Receptor Signaling;reconstitution;recruit;Reperfusion Injury;Research;Resolution;response to injury;Role;Sampling;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Site;Spleen;spleen transplantation;Splenic Red Pulp;Stromal Cell-Derived Factor 1;Structure of parenchyma of lung;Surgical Models;Techniques;Testing;Tight Junctions;tool;trafficking;transcriptomics;Translations;Transplantation;Transplantation Surgery;two-photon;Variant;Vascularization;Work

PROJECT_TITLE: Role of spleen educated monocytes in mediating ischemia-reperfusion injury followinglung transplant surgery

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

PHR: PROJECT NARRATIVE (relevance) In an 11-center prospective cohort study of 300 children with a tracheostomy requiring home ventilation, investigators propose to refine the “one pathogen-one disease” ARI paradigm to an ecosystem-wide understanding of ARI pathophysiology and severity in order to develop more precise ARI treatment strategies for this high-risk population.

PI_NAMEs: MANSBACH, JONATHAN M (contact)

PROGRAM_OFFICER_NAME: UPADHYAY, MEENU MISHRA

PROJECT_TERMS: Acute respiratory infection;Address;Antibiotics;aspirate;Award;Bacteria;Bacterial Genes;biobank;Biological;Cause of Death;Child;cohort;cost;Data;Death Rate;Disease;Ecosystem;Emergency Medicine;Enrollment;Functional disorder;Funding;Future;Gene Expression;Genes;Goals;Haemophilus influenzae;health care service utilization;Healthcare;Hemophilus;high risk population;Home;Hospital Charges;Hospitalization;Hospitals;host microbiome;Immune response;Infection;Inflammatory;insight;Intensive Care;Interleukin-6;Knowledge;Link;Longitudinal Studies;Measures;metatranscriptome;metatranscriptomics;microbial;microbiome;microbiome composition;microbiota composition;Moraxella;Multicenter Studies;Nutritional;Nutritional Immunity;Oxygen;Participant;pathogen;Pathogenicity;Pathway interactions;Pediatric Acute Lung Injury;phenotypic data;Population;Prospective, cohort study;Protocols documentation;Research;Research Personnel;respiratory colonization;respiratory microbiome;respiratory microbiota;sample collection;Sepsis;Severities;Signal Pathway;Site;Specimen;Suction;Testing;Trachea;Tracheostomy procedure;transcriptome;transcriptome sequencing;transcriptomics;treatment strategy;United States National Institutes of Health;ventilation;Ventilator;Viral;Viral Bronchiolitis;Viral Respiratory Tract Infection;Virulence Factors;virulence gene;Virus;Virus Diseases;Work

PROJECT_TITLE: Viral respiratory infections in a tracheostomy cohort: Microbiome-host interplay

STUDY_SECTION: CRFS

STUDY_SECTION_NAME: Clinical Research and Field Studies of Infectious Diseases Study Section[CRFS]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Mental Illness;Neurodegenerative;Neurosciences;Parkinson's Disease

ORG_CITY: SAN FRANCISCO

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative Dopamine replacement therapy of Parkinson’s Disease is critical to manage movement symptoms, but frequently complicated by the development of treatment-related involuntary movements or impulsive behaviors. Understanding how dopamine replacement therapy produces its therapeutic and pathological effects through distinct groups of brain cells would make it possible to harness the therapeutic effects without the complications. This project will measure brain activity in a mouse model of Parkinson’s Disease, to better understand how dopamine replacement therapy improves movement, causes involuntary movements, or leads to impulsive behavior.

PI_NAMEs: NELSON, ALEXANDRA  (contact)

PROGRAM_OFFICER_NAME: SIEBER, BETH-ANNE

PROJECT_TERMS: abnormal involuntary movement;Acute;Agonist;Animal Model;Animals;Attenuated;Behavior;Binge Eating;Brain;brain cell;cell type;Compulsive Behavior;Corpus striatum structure;Coupled;Decision Making;Disabling;discounting;Disease;Dopamine;Dopamine Agonists;dopamine replacement therapy;Dose;Drug-Induced Abnormalities;Dyskinetic syndrome;Electrophysiology (science);Funding;Gambling;Genetic;Globus Pallidus;human imaging;Hyperactivity;imaging study;improved;Impulse Control Disorders;Impulsive Behavior;Impulsivity;in vivo;Individual;Inhibitory Synapse;Involuntary Movements;L-DOPA induced dyskinesia;Levodopa;Measurement;Measures;Mediating;Motor;motor behavior;motor symptom;mouse model;Movement;Mus;Nature;neural;neural correlate;Neurons;Optics;optogenetics;Parkinson Disease;Parkinsonian Disorders;parkinsonian rodent;Pars Externa;Pathologic;Pathological Gambling;Pathway interactions;Pattern;Persons;Pharmaceutical Preparations;pramipexol;Process;response;Risk Behaviors;Role;Severities;Shapes;side effect;Signal Transduction;Symptoms;Synapses;Syndrome;Testing;Therapeutic;Therapeutic Effect;therapy development;tool;United States National Institutes of Health;Work

PROJECT_TITLE: Striatal Mechanisms of Dyskinesia and Impulse Control in Parkinson’s Disease

STUDY_SECTION: SMN

STUDY_SECTION_NAME: Sensory-Motor Neuroscience Study Section[SMN]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Cannabinoid Research;Clinical Research;Pediatric;Prevention;Social Determinants of Health;Substance Misuse;Tobacco

ORG_CITY: SAN MARCOS

ORG_DEPT: PSYCHOLOGY

ORG_NAME: CALIFORNIA STATE UNIVERSITY SAN MARCOS

PHR: Project Narrative This project will produce a host of novel data to understand behavioral economic demand for cannabis and tobacco among young adult dual users, which is critical to progress in preventing and treating dual use among a high-risk group. This study will produce the first prospective investigation of behavioral economic demand for cannabis and tobacco (cigarettes and/or e- cigarettes) over one year (Aim 1), the first evaluation of demand as an antecedent of dual tobacco and cannabis product use and characterization of the relative contributions of demand indices for each substance to behavioral health sequelae of use (Aim 2), and the first model testing whether demand for cannabis and tobacco mediates a link between social cognitive theory-based factors and cannabis and tobacco use (Aim 3).

PI_NAMEs: PULVERS, KIMBERLEY  (contact)

PROGRAM_OFFICER_NAME: GARTRELL, KYUNGSOOK

PROJECT_TERMS: addiction;Address;Affect;Age;Area;Back;behavior measurement;Behavioral;behavioral economics;behavioral health;Cannabis;Carbon Monoxide;Characteristics;Cigarette;cohort;Collaborations;cost;Data;Dependence;design;Drug Addiction;Drug usage;Elasticity;Electronic cigarette;Ethnic Origin;Evaluation;Expectancy;experience;Future;Health;high risk population;improved;indexing;Individual;Intervention;Investigation;Knowledge;Link;Literature;marijuana use;marijuana user;Measurement;Measures;Mediating;Mission;Modeling;Monitor;Motivation;National Institute of Drug Abuse;nicotine use;novel;Outcome;personalized approach;Policies;prevent;Prevention;prospective;Public Health;Race;Recording of previous events;recruit;Reporting;Research;Respiratory Signs and Symptoms;Risk;risk perception;Science;sex;social;social cognitive theory;Students;substance use;Surveys;Testing;theories;Time;timeline;Tobacco;Tobacco Dependence;Tobacco use;tobacco user;Universities;vaping;Visit;young adult

PROJECT_TITLE: Behavioral Economic Demand for Cannabis and Tobacco among Young Adult Dual Users


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Bioengineering;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hematology;Nanotechnology;Orphan Drug;Pain Research;Racial and Ethnic Minority Health Research;Rare Diseases;Sickle Cell Disease

ORG_CITY: WYNANTSKILL

ORG_NAME: VASCULAR VISION PHARMACEUTICALS COMPANY

ORG_STATE: NY

PHR: Narrative: Sickle cell disease (SCD) is complex and requires multiple modes of action to optimally manage painful vaso-occlusive crisis (VOC) and associated poor quality of life. Several drugs are approved for the treatment of SCD, however, none retain all of the essential properties necessary for VOC management including anti-adhesion, anti-inflammation, anti-sickling, and antithrombosis. Vascular Vision Pharmaceuticals (VVP) specializes in the development of novel therapies for the treatment of sickle cell disease using first in class non- anticoagulant heparin (S-NACH) that retains all of these essential properties while removing dose limiting toxicity, particularly bleeding associated with this class of drugs; the multiple modes of action and S-NACH’s nanoformulation (VVP728) provide a highly desirable therapeutic for SCD management,

PI_NAMEs: KORCZAK, BOZENA  (contact)

PROGRAM_OFFICER_NAME: GOLDBERG, ILANA GRACE

PROJECT_TERMS: Accounting;Adhesions;Adopted;Affect;African American;African American population;alternative treatment;Binding Proteins;Blood Transfusion;Blood Vessels;Canis familiaris;Cardiovascular system;Cells;Central Nervous System;Cessation of life;Chronic;Clinical;Complex;cost;Data;Development;Disease;Disease Management;Disease Progression;disorder prevention;Dose;Dose Limiting;Drug Modelings;Endothelium;Fatigue;FDA approved;first-in-human;Frequencies;Functional disorder;genotoxicity;Genotype;global health;Glutamine;health disparity;Hematopoietic Stem Cell Transplantation;Hemochromatosis;Hemoglobin concentration result;Hemorrhage;Heparin;Hispanic Americans;Hospitalization;hydroxyurea;improved;In Vitro;in vivo;Individual;Inflammation;Life Expectancy;Low-Molecular-Weight Heparin;manufacturing scale-up;Methods;Micronucleus Tests;Morbidity - disease rate;mortality;mouse model;multimodality;Mutation;nano;nanoformulation;nanoparticle;novel;novel therapeutics;Organ;Organ failure;Pain;Pathway interactions;Patients;Persons;Pharmaceutical Preparations;Pharmacodynamics;pharmacokinetics and pharmacodynamics;Pharmacologic Substance;Phase;Phase I Clinical Trials;Phase II/III Trial;Physiological;polymerization;Polymers;pre-clinical;preclinical study;premature;Property;public health priorities;Quality of life;Relaxation;Research;Resolution;respiratory;Risk Reduction;Rodent;Safety;secondary endpoint;Selectins;Sickle Cell Anemia;Sickle Cell Trait;sickling;Small Business Innovation Research Grant;Small Business Technology Transfer Research;stroke risk;subcutaneous;Sulfate;Testing;Therapeutic;therapeutic candidate;Thrombosis;thrombotic;Toxic effect;Toxicology;Transfection;Treatment Cost;treatment strategy;United Nations;Vascular Diseases;vaso-occlusive crisis;Vision;World Health Organization

PROJECT_TITLE: Sulfated Non-Anticoagulant Heparin Nanoparticle (VVP728) for Sickle Cell Disease Management

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-VH-C(10)B]


ORG_CITY: SAN JUAN

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF PUERTO RICO MED SCIENCES

ORG_STATE: PR

PHR: Project Narrative       The  proposed  Hispanic  Alliance  for  Clinical  and  Translational  Research  is  relevant  to  public  health  because  it  will  help  advance  our  fundamental  knowledge  of  ethnic- specific  factors  that  could  explain  the  disproportionate burden  of  certain  diseases,  and  the  limited  or  lack  of  effective  treatment  for  this  ethnic  subgroup,  which  is     increasingly represented in the US mainland population. The long- term goal of the Alliance is to transform clinical  and  translational  research  in  Hispanic  populations  in  the  Mainland  and  in  Puerto  Rico  by  promoting  inter-  disciplinary  collaboration  and  leverage  of  resources  to  address  diseases  affecting  Hispanic  communities.  The  project  is  relevant  to  the  NIH  mission  because  it  will  contribute  with  training  the  next  generation  of   scientists, develop research capacities, and will enhance the diversity of the scientific workforce.

PI_NAMEs: LUCIANO, CARLOS A. (contact);MOROU-BERMUDEZ, EVANGELIA

PROGRAM_OFFICER_NAME: BISSONETTE, GREG

PROJECT_TERMS: Academia;Address;Adoption;Affect;Bioinformatics;biomedical informatics;Biometry;Cardiometabolic Disease;career development;Clinical Research;clinical translation;Collaborations;Communicable Diseases;Communication;Communities;community academic partnership;community engaged research;community engagement;Community Health;Community Networks;community organizations;Community Outreach;community partners;community research;community-centered;cyber infrastructure;data infrastructure;data warehouse;Dedications;Development;Development Plans;Disasters;Disease;effective therapy;Emerging Communicable Diseases;Ensure;Epidemiology;Ethnic Origin;Ethnic Population;Evaluation;Foundations;Funding;Generations;Goals;Government;Health;health care delivery;health data;Health Policy;Health Sciences;Healthcare;Hispanic;hispanic community;Hispanic Populations;Human Resources;improved;Infrastructure;innovation;Institution;interdisciplinary collaboration;Island;Knowledge;Laboratories;Leadership;Malignant Neoplasms;Medical;medical schools;medically underserved;Mentors;Methods;Mission;Modeling;next generation;Outcome;Participant;Pilot Projects;Population;Positioning Attribute;Process;programs;Public Health;Puerto Rico;recruit;Research;research and development;Research Design;research facility;Research Personnel;Resources;Safety;Science;Scientist;Services;Specific qualifier value;statistics;Structure;synergism;System;Technology;Training;Training Activity;Translational Research;translational research program;United States;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Hispanic Alliance for Clinical and Translational Research (Alliance)


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Racial and Ethnic Minority Health Research

PI_NAMEs: CRUZ-CORREA, MARCIA ROXANA (contact)

PROJECT_TERMS: Achievement;Address;Advisory Committees;Affect;Area;authority;base;Basic Science;Cardiometabolic Disease;Caribbean Hispanic;Caring;Clinical;clinical development;Clinical Research;clinical translation;Collaborations;collaboratory;Communicable Diseases;Communication;Communities;Community Health;community organizations;cost effective;cost efficient;design;Development;Disasters;Disease;Emerging Communicable Diseases;Ensure;Evaluation;experience;flexibility;Foundations;Funding;Goals;Government Agencies;Health;Health Sciences;Healthcare;Hispanic;Hispanic Populations;Hospitals;improved;Infrastructure;innovation;Institution;Island;Lead;Leadership;Malignant Neoplasms;Medical;medical schools;medically underserved;medically underserved population;Modeling;Monitor;multidisciplinary;operation;organizational structure;outreach;Policies;Population;Positioning Attribute;Procedures;Productivity;programs;Puerto Rico;Research;Research Infrastructure;Research Institute;Research Personnel;Resource-limited setting;Resources;Science;Services;skills;Structure;Support System;tool;Translating;Translational Research;United States National Institutes of Health;Universities

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: Project Narrative T cell anergy is a critical mechanism of peripheral T cell tolerance, and defects in the generation or maintainence of anergy against self antigens leads to autoimmune disease. We have shown that expression of the transcription factor Runx1 is reduced in naturally anergic CD4 T cells in WT mice, which leads to the upregulation of the inhibitory adaptor molecule Dap2IP. The focus of this proposal is to uncover the mechanisms by which Dab2IP overexpression represses TCR stimulation leading to T cell non- responsiveness.

PI_NAMEs: SHAPIRO, VIRGINIA SMITH (contact)

PROGRAM_OFFICER_NAME: JIANG, CHAO

PROJECT_TERMS: Acceleration;acute myeloid leukemia 1 protein;anergy;Autoantigens;Autoimmune Diseases;Autoimmunity;autoreactive T cell;Biochemical Pathway;Bone Marrow;CD28 gene;CD4 Positive T Lymphocytes;Cells;Chimera organism;conditional knockout;Defect;Development;Diabetes Mellitus;engineered T cells;Frequencies;Generations;Guanosine Triphosphate;Hydrolysis;Immune response;In Vitro;in vivo;in vivo Model;insight;Interleukin-2;Knockout Mice;Maintenance;Memory;Mitogen-Activated Protein Kinases;Modeling;Molecular;Mus;novel;novel therapeutics;overexpression;Pathway interactions;Peptides;Peripheral;peripheral tolerance;PIK3CG gene;prevent;Production;programs;Proliferating;ras GTPase-Activating Proteins;Regulation;Repression;Role;Signal Pathway;Signal Transduction;Stimulus;Structure;T cell anergy;T cell regulation;T-Cell Activation;T-Cell Development;T-Lymphocyte;T-Lymphocyte Subsets;Tamoxifen;transcription factor;transcriptome sequencing;Transgenic Mice;Up-Regulation;Work

PROJECT_TITLE: Altered TCR signaling in anergy

STUDY_SECTION: TTT

STUDY_SECTION_NAME: Transplantation, Tolerance, and Tumor Immunology Study Section[TTT]


PI_NAMEs: IRIZARRY-RAMIREZ, MARGARITA  (contact)

PROJECT_TERMS: Achievement;Address;African American;African American population;Area;Behavioral;Cardiometabolic Disease;career;Certification;Chronic Disease;Clinical;Clinical Research;Collaborations;Communicable Diseases;Communities;community engagement;Community Health;Community Outreach;community partners;Competence;design;Development;Disease;disease disparity;disorder prevention;Doctor of Pharmacy;Education;Educational Curriculum;Emerging Communicable Diseases;experience;Faculty;Fostering;Foundations;Goals;Grant;Health;health care quality;Health Care Research;health disparity;Health Professional;Healthcare;healthy lifestyle;Hispanic;Hispanic Americans;hispanic community;Hispanic Populations;improved;Individual;Infrastructure;innovation;Institution;Interdisciplinary Study;interest;Investments;Latino;Malignant Neoplasms;Medical;medically underserved;medically underserved population;Mentors;minority communities;minority investigator;Minority-Serving Institution;Modeling;Native Americans;Nurses;Occupational Therapist;Online Systems;Pacific Islander;Participant;Patients;peer;Peer Review;Personal Satisfaction;physical therapist;Population;Population Group;Positioning Attribute;Process;Productivity;programs;Publications;Puerto Rico;Qualifying;Recording of previous events;Research;Research Design;research faculty;Research Personnel;Schedule;Science;Scientist;success;Technology;Time;Training;training opportunity;Training Programs;Translational Research;translational scientist;Translations;Underrepresented Minority;underserved community;Underserved Population;United States Dept. of Health and Human Services;Universities;Writing

PROJECT_TITLE: Professional Development Core


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research

PI_NAMEs: RIVAS-TUMANYAN, SONA  (contact)

PROJECT_TERMS: analytical method;Award;Awareness;Big Data;Biometry;Cardiometabolic Disease;career;Center for Translational Science Activities;Clinical;Clinical Investigator;Clinical Research;Collaborations;Communicable Diseases;Communities;community engaged research;Community Health;Data Analyses;data management;design;Development;Disasters;Discipline;Disease;Educational Curriculum;Emerging Communicable Diseases;Ensure;Epidemiology;Funding;Funding Mechanisms;Genomics;Goals;Grant;Health;Health Benefit;Healthcare;Hispanic;hispanic community;Hispanic Populations;improved;Information Dissemination;Infrastructure;innovation;Institution;Journals;Knowledge;Malignant Neoplasms;medically underserved;member;Methodology;Methods;new technology;Paper;Phase;Play;population health;Positioning Attribute;prevent;Proteomics;Publications;Publishing;Puerto Rico;Qualifying;Qualitative Research;recruit;Research;Research Design;Research Methodology;Research Personnel;Research Project Grants;research study;Resources;Role;Services;skills;sound;Statistical Data Interpretation;Statistical Methods;tool;Training;training opportunity;Training Programs;Translational Research;United States

PROJECT_TITLE: Biostatistics, Epidemiology, and Research Design Core


ORG_CITY: LARAMIE

ORG_DEPT: ZOOLOGY

ORG_NAME: UNIVERSITY OF WYOMING

ORG_STATE: WY

PHR: Narrative The mission of the Wyoming Sensory Biology COBRE (SBC) is to foster and conduct high-quality scientific research that advances the understanding of our sensory systems and disorders related to them. SBC will accomplish its mission through the augmentation and strengthening of UW’s institutional biomedical research capacity by building a critical mass of investigators whose research interests are centered on sensory processes at the molecular, cellular, physiological and system levels, and by increasing the competitiveness of SBC investigators through mentoring and research support.

PI_NAMEs: SUN, QIAN-QUAN  (contact)

PROGRAM_OFFICER_NAME: REVILLEZA, MARIA

PROJECT_TERMS: Achievement;Adaptive Behaviors;Address;Affect;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Amyotrophic Lateral Sclerosis;Animal Model;Area;autism spectrum disorder;Awareness;Basic Science;Behavior;Biology;Biomedical Research;Cell Nucleus;Centers of Research Excellence;Child;Chronic Disease;chronic pain;Cognitive;Collaborations;Communication;cost;Development;developmental disease;Disease;Educational Activities;Evaluation;evidence base;Face;Fostering;Functional disorder;Funding;Goals;Growth;Health;Human;human old age (65+);Impairment;improved;Inflammation;innovation;Institution;interest;Journals;Knowledge;Lateral;Long-Term Care;maladaptive behavior;Manuscripts;Medial;Mental disorders;Mental Health;Mentors;Mission;Molecular;multidisciplinary;National Institute on Deafness and Other Communication Disorders;Nervous System Disorder;Neuroglia;Neurons;next generation;novel;Obesity;operation;Output;Oxytocin;parabrachial nucleus;parvocellular;Peer Review;Persons;Phase;Physiological;Positioning Attribute;Prefrontal Cortex;Process;programs;Public Health;Publications;Publishing;Recovery;recruit;Research;Research Infrastructure;Research Personnel;Research Support;Resource Sharing;Resources;responsible research conduct;Role;Scientist;Sensory;Sensory Disorders;sensory mechanism;Sensory Process;sensory stimulus;sensory system;Signal Transduction;social;Social Behavior;Spinal cord injury;System;Training;Translational Research;United States;United States National Institutes of Health;Universities;visual learning;Wyoming

PROJECT_TITLE: Wyoming Sensory Biology COBRE


NIH_SPENDING_CATS: Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: ACOSTA-PEREZ, EDNA  (contact)

PROJECT_TERMS: Academia;Address;Adoption;Affect;Age;Agreement;Alzheimer's Disease;Asthma;Attention;Breast Cancer Patient;Cardiometabolic Disease;Caring;Child Abuse and Neglect;Clinical Research;Collaborations;Communicable Diseases;Communities;community academic partnership;community building;community collaboration;Community Developments;community engagement;Community Health;Community Outreach;Community Participation;community partners;community research;community setting;Decision Making;Development;Disasters;Disease;Disparity;dissemination strategy;Drug abuse;Education;Emerging Communicable Diseases;empowerment;Ensure;evidence base;experience;Exposure to;Fostering;General Population;Goals;Health;Health behavior;health care quality;Health Care Research;health disparity;Health Policy;Health Priorities;Health Promotion;Health Services;Health Services Accessibility;Healthcare;Hispanic;hispanic community;Hispanic Populations;HIV;improved;Incidence;Individual;Inequity;Information Systems;Infrastructure;innovation;Institution;Intervention;Island;Knowledge;Leadership;Learning;Malignant Neoplasms;Measures;medically underserved;Medicare;member;Mentors;Modeling;mortality;Nature;New York;Outcome;Policy Maker;poor health outcome;population health;Positioning Attribute;Poverty;Pregnancy in Adolescence;Pregnancy Rate;Prevention;Privatization;Process;programs;Public Health;Public Policy;Puerto Rico;Quality of Care;Reporting;Research;Research Design;Research Personnel;Research Priority;Resource Allocation;Resources;Risk;Role;sex;Sexual Health;skills;social;Social Change;social norm;social stigma;Structure;Training;Translational Research;Trust;US State;Voice

PROJECT_TITLE: Community Engagement and Outreach Core


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding

PROJECT_TERMS: Acceleration;Address;Advisory Committees;Award;Biology;Budgets;career;career development;Centers of Research Excellence;college;Core Facility;Cost Sharing;Data Science;Development;Evaluation;experience;faculty mentor;Faculty Recruitment;Funding;Goals;Grant;Growth;Image;improved;Journals;Lead;Leadership;Manuscripts;Mentors;Mentorship;Microscopy;multidisciplinary;operation;outreach;Peer Review;Peer Review Grants;Phase;Pilot Projects;programs;Publications;Publishing;recruit;Research;research faculty;Research Infrastructure;Research Personnel;Research Project Grants;Resources;Scientist;Secure;Sensory;statistics;Teacher Professional Development;Training and Infrastructure;United States National Institutes of Health;Universities;Wyoming


PI_NAMEs: WOJNA, VALERIE  (contact)

PROJECT_TERMS: Address;Advanced Development;Affect;Award;Basic Science;Biometry;Cardiometabolic Disease;career development;Clinical;clinical application;Clinical Research;clinical translation;Collaborations;Communicable Diseases;Communities;community based research;community engagement;community health study;community involvement;Community Outreach;Coordination and Collaboration;cost;Data;Dedications;design;Development;Development Plans;Diagnosis;Disadvantaged;Disasters;Disease;Emerging Communicable Diseases;Epidemiology;Evaluation;experience;Faculty;Fostering;Funding;Goals;Grant;Health;Health Services Accessibility;Healthcare;Hispanic;Hispanic Populations;HIV;Improve Access;improved;Infrastructure;innovation;Institution;inter-institutional;Knowledge;Malignant Neoplasms;medically underserved;meetings;Mentors;Mentorship;Minority;minority investigator;minority scientist;Monitor;multidisciplinary;Neurosciences;next generation;Outcome;Personal Satisfaction;Pilot Projects;Population;Positioning Attribute;Prevention;Process;Productivity;programs;Publications;Puerto Rico;Research;Research Activity;Research Design;Research Personnel;Resources;Schedule;Science;Scientist;Secure;Series;skills;Structure;success;Technology;Time;Translating;Translational Research;translational scientist;Underrepresented Minority;Underserved Population;United States National Institutes of Health;Woman;Work;working group

PROJECT_TITLE: Pilot Projects Program


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Genetics;Human Genome;Neurosciences

PI_NAMEs: ZHANG, ZHAOJIE  (contact)

PROJECT_TERMS: Aging;base;Biology;Brain;brain tissue;Centers of Research Excellence;Collaborations;community college;Core Facility;COVID-19 pandemic;Development;Disease;Equipment;Faculty;Fees;Fostering;Funding;Future;genome analysis;genomic profiling;Genomics;Goals;Grant;Human Resources;Image;improved;in vivo;innovation;Institution;instrumentation;Leadership;Light;Maps;member;Microscope;microscopic imaging;Microscopy;Molecular Analysis;molecular imaging;Morphology;Names;Nervous System;nervous system imaging;Neurons;next generation;operation;Pathologic;Pathway interactions;Phase;Positioning Attribute;Productivity;Proteins;Research;Research Personnel;response;Role;Sensory;sensory mechanism;sensory system;Services;Spinal Cord;Structure;success;Synapses;Technology;Three-Dimensional Imaging;training opportunity;Transcript;transcriptome;transcriptomic profiling;transcriptomics;Universities;Visualization;Wyoming

PROJECT_TITLE: Integrated Microscopy Core Facility


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Dental, Oral, and Craniofacial Disease;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: Chicago

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: NARRATIVE Caries prevalence, morbidity, and associated disparities in children have been well documented nationally and locally. Research now is trying to understand why these disparities persist. The proposed Coordinated Oral Health Promotion (CO-OP) Chicago Cohort Study will transition current trial participants into a longitudinal cohort to determine predictors of oral health behaviors and caries risk in low-income, urban young children over time.

PI_NAMEs: MARTIN, MOLLY A (contact)

PROGRAM_OFFICER_NAME: FISCHER, DENA

PROJECT_TERMS: 3 year old;Absenteeism;Address;Adverse effects;Affect;Affordable Care Act;Age;aged;arm;Behavior;Black Populations;Black race;Caregivers;Chicago;Child;Child Behavior;Child Rearing;Childhood;Clinical;cognitive development;cohort;Cohort Studies;Communities;community intervention;community-level factor;cost;cost effective;COVID-19;Data;Data Collection;Data Sources;demographics;Dental;Dental Care;Dental caries;Dental Hygiene;Dental Plaque;Diet;Direct Costs;Disease;Disparity;Disparity population;effectiveness testing;Enrollment;Ethnic Origin;experience;Family;Fluorides;food security;Frequencies;Funding;Future;General Anesthesia;Genetic;Grant;Health;Health behavior;health belief;health data;health disparity;Health Food;Health Insurance;health literacy;Health Promotion;health related quality of life;Health Services Accessibility;Healthcare;high risk;Hispanic;Hispanic Populations;Home;improved;Individual;Intervention;lens;Longitudinal cohort;Low income;lower income families;Mediating;Medicaid;Minority Groups;Modeling;Morbidity - disease rate;National Institute of Dental and Craniofacial Research;Nutritional;Oral health;Pain;Participant;Patient Self-Report;Positioning Attribute;Prevalence;Preventive;primary outcome;Provider;Psychosocial Factor;Randomized, Controlled Trials;Recommendation;recruit;Reporting;Research;research and development;Risk;Risk Factors;risk prediction;Schools;Sedation procedure;social;Surveys;Techniques;Testing;theories;therapy development;Time;Toothbrushing;Toothpaste;United States;Violence;Water fluoridation;Work


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Precision Medicine

ORG_CITY: CAMBRIDGE

ORG_NAME: BROAD INSTITUTE, INC.

PHR: Project Narrative Genetic alterations in human cancer have been systematically studied over the past decade, but the impact of a majority of these changes on the proteome—the functional end of the genome—are poorly understood. In this project we will implement a large-scale automated data analysis platform that will integrate clinical, genomics and mass spectrometry-based proteomics data from the same samples/tumors, and bring to bear novel big-data algorithms and analysis methods to shed new light on the biology of cancer, the response and resistance to drug treatments and, importantly, help to identify new targets for therapeutic intervention.

PI_NAMEs: GETZ, GAD A;MANI, DENKANIKOTA R (contact)

PROGRAM_OFFICER_NAME: HILTKE, TARA

PROJECT_TERMS: Affect;Affinity;Algorithmic Analysis;Algorithms;antigen binding;Antigen Targeting;Big Data;Biochemical;Bioinformatics;Biological;Biological Models;Cancer Biology;cancer biomarkers;cancer subtypes;cancer type;Clinical;cloud based;cohort;Collaborations;Collection;Complex;Computational Biology;computerized data processing;Copy Number Polymorphism;Data;Data Analyses;Data Commons;data repository;Data Set;Databases;Decision Aid;Decision Making;differential expression;Differentiation Antigens;Disease;Dose;Drug resistance;Drug Targeting;Encapsulated;flexibility;Foundations;Genes;Genetic;Genome;genomic data;Genomics;HLA Antigens;Human;Immune;improved;Individual;individual patient;insight;interest;laboratory experiment;Leadership;Ligase;Malignant Neoplasms;Maps;Mass Spectrum Analysis;Measurement;metabolomics;Methodology;Methods;Modeling;Multiomic Data;multiple omics;Mutate;Mutation;neoantigens;new therapeutic target;next generation sequencing;novel;Pathway Analysis;Pathway interactions;Peptides;personalized medicine;Pharmaceutical Preparations;Pharmacotherapy;Phase;phenotypic data;Phosphotransferases;Post Translational Modification Analysis;Post-Translational Modification Site;Post-Translational Protein Processing;Process;Prognostic Marker;Proteins;proteogenomics;Proteome;Proteomics;Publications;Reporting;Reproducibility;response;Retrieval;RNA;Sampling;Scientist;Signal Transduction;Site;Source;Specific qualifier value;Standardization;Subgroup;System;Systems Biology;Techniques;Therapeutic;Therapeutic Intervention;therapeutic target;Tissues;tool;Transcript;transcriptomics;translational pipeline;Translational Research;tumor;ubiquitin isopeptidase;Validation

PROJECT_TITLE: Center for comprehensive proteogenomic data analysis


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research

PI_NAMEs: NOBOA-RAMOS, CARLAMARIE  (contact)

PROJECT_TERMS: Achievement;Address;Affect;Back;Budgets;Center for Translational Science Activities;Clinical Research;Collaborations;Community Integration;Community Participation;Complex;Data;Data Collection;data repository;Dedications;Development;Disasters;Elements;Emerging Communicable Diseases;Evaluation;experience;Goals;Health;Hispanic;Hispanic Populations;improved;Individual;Infrastructure;innovation;Institution;Intervention;Interview;Investments;Island;Journals;Knowledge;Logic;medically underserved;member;Methods;Mission;Modeling;Monitor;operation;Outcome;Pathway Analysis;Peer Review;Performance;Positioning Attribute;Process;Productivity;programs;Puerto Rico;Qualitative Research;research facility;Research Methodology;research study;Research Support;Resources;Scientist;Site;skills;Social Network;Structure;Surveys;symposium;Techniques;Thinking;Translational Research

PROJECT_TITLE: Tracking and Evaluation Core


PI_NAMEs: BONILLA-FELIX, MELVIN  (contact)

PROJECT_TERMS: Address;Adherence;burden of illness;Cardiometabolic Disease;Caribbean Hispanic;Clinical Practice Guideline;Clinical Research;Communicable Diseases;Communities;Core Facility;cost effective;cultural competence;Data;Development;Disasters;Disease;effective therapy;Emerging Communicable Diseases;Ensure;ethnic minority;Ethnic Origin;Ethnic Population;Goals;Good Clinical Practice;Health;Healthcare;Hispanic;hispanic community;Hispanic Populations;Hispanic-serving Institution;human subject;improved;Infrastructure;Interdisciplinary Study;Knowledge;Language;Malignant Neoplasms;medically underserved;medically underserved population;Methodology;Minority;multidisciplinary;Participant;Population;Positioning Attribute;Process;programs;Puerto Rico;quality assurance;racial minority;recruit;Regulation;Research;research facility;Research Personnel;research study;Resources;retention rate;Scientist;Structure;Translating;Translational Research;treatment guidelines

PROJECT_TITLE: Clinical Research Resources and Facilities


ORG_CITY: COLUMBIA

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

ORG_STATE: MO

PHR: PROJECT NARRATIVE Advances in the field of comparative medicine have a profound impact on our understanding of human health and disease. Veterinarians bring a unique perspective to the field because of their broad training in animal medicine and modeling. Training veterinarians to become successful independent comparative medicine researchers will position them to contribute to advancing understanding of human health and disease.

PI_NAMEs: BRYDA, ELIZABETH C (contact);FRANKLIN, CRAIG L

PROJECT_TITLE: Postdoctoral Training in Comparative Medicine


NIH_SPENDING_CATS: Bioengineering;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Clinical Trials and Supportive Activities;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Networking and Information Technology R&D (NITRD);Racial and Ethnic Minority Health Research

PI_NAMEs: MAYS, MARY HELEN (contact)

PROJECT_TERMS: Acute;bilingualism;Bioinformatics;biomedical informatics;Cardiometabolic Disease;Caribbean region;Caring;Clinical;clinical care;Clinical Data;clinical data warehouse;Clinical Research;Clinical Trials;Communicable Diseases;Communities;Conduct Clinical Trials;Continuing Education;cyber infrastructure;Data;Data Collection;data infrastructure;data mining;data warehouse;design;Development;Disasters;Disease;drug efficacy;Education;Effectiveness;electronic health data;Electronic Health Record;Emerging Communicable Diseases;Environment;experimental study;Face;field study;Goals;Health;health care delivery;health data;Health Insurance Portability and Accountability Act;Health Personnel;Health Status;Healthcare;Hispanic;Hispanic Populations;Hospitals;improved;Individual;Informatics;informatics tool;Infrastructure;innovation;Institution;interdisciplinary approach;Knowledge;Language;Lead;Malignant Neoplasms;Maps;Medical;medically underserved;Medicine;monitoring device;Online Systems;Outcome;Participant;Pathway interactions;Population;population health;Positioning Attribute;programs;Public Health Informatics;Puerto Rican;Puerto Rico;recruit;Research;Research Personnel;Research Project Grants;research study;Research Support;Resources;routine care;Rural Community;Secure;Services;skills;Source;support tools;System;Technology;tool;Training;Training and Education;Training Programs;Translational Research;translational scientist;Urban Community;volunteer;web portal;web site;Work

PROJECT_TITLE: Biomedical Informatics, Bioinformatics and Cyberinfrastructure  Enhancement Core


PI_NAMEs: PORTER, JAMES T. (contact)

PROJECT_TERMS: Acceleration;Address;Affect;Agreement;Behavioral Sciences;Cardiometabolic Disease;Centers of Research Excellence;Clinical Investigator;Clinical Research;Collaborations;Communicable Diseases;Communities;community engagement;Community Participation;Complement;Core Facility;Data;Development;Disasters;Disease;Educational workshop;Emerging Communicable Diseases;Environment;Foundations;Funding;Goals;Health;Health Benefit;Health Sciences;Healthcare;Hispanic;Hispanic Populations;Histopathology;Human;Improve Access;improved;Infrastructure;Institution;institutional capacity;investigator training;Investments;Joints;Laboratories;laboratory equipment;laboratory experience;Laboratory Research;Laboratory Technicians;Latino Population;Letters;Malignant Neoplasms;Measures;Medical;medical schools;medically underserved;Molecular Biology;Outcome;outreach;Population;Positioning Attribute;Public Health;Publications;Puerto Rico;recruit;Research;research facility;Research Personnel;Research Project Grants;Research Support;Resources;Rest;Science;Services;skills;stem;success;Technical Expertise;Technology;Training;Training and Education;Training Support;Translating;Translational Research;translational scientist;United States;United States National Institutes of Health;Universities;Update

PROJECT_TITLE: Technologies and Resources for Research Laboratories


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: The aim of this study is to elucidate how TAR-DNA binding protein 43 (TDP-43) misfolding and aggregation affects the function of oligodendrocytes, the cells responsible for myelination in the central nervous system. Additionally, we will investigate whether oligodendrocytes can carry and spread pathogenic TDP-43 species to neighboring neurons, contributing to the progression of TDP-43 proteinopathies. By gaining insights into these mechanisms, our studies will enhance the understanding of TDP-43-related disorders and provide a foundation for future research and potential interventions to improve health outcomes and reduce the impact of neurodegenerative diseases.

PI_NAMEs: PORTA ANTOLINEZ, SILVIA  (contact)

PROGRAM_OFFICER_NAME: LI, TONG

PROJECT_TERMS: Affect;age related;alpha synuclein;Amyloid beta-Protein;Amyotrophic Lateral Sclerosis;Apoptosis;Basic Science;Biological Assay;Brain;Cell Culture Techniques;Cell Death;Cell Survival;Cells;Central Nervous System;Coculture Techniques;Cytoplasm;Dementia;Development;Disease;Disease Progression;Foundations;Frontotemporal Lobar Degenerations;Functional disorder;Future;Health;Human;human disease;improved;In Vitro;in vitro Model;insight;Intervention;Investigation;limbic-predominant age-related TDP-43 encephalopathy;loss of function;Measures;misfolded protein;Mitochondria;Modeling;Molecular;Mutation;myelination;Necrosis;Nerve Degeneration;Neurodegenerative Disorders;Neuroglia;Neurons;neuropathology;novel;Nuclear Protein;oligodendrocyte progenitor;Oligodendroglia;Outcome;Pathogenicity;Pathologic;Pathology;Phosphorylation;pre-clinical research;Process;Production;protein TDP-43;Rattus;Reactive Oxygen Species;Research Project Grants;Role;Spinal Ganglia;stem cell differentiation;stem cells;tau Proteins;TDP-43 aggregation;Time;tool;Transgenic Mice;transmission process;Wild Type Mouse

PROJECT_TITLE: Deciphering TDP-43 Proteinopathy: Unveiling the Consequences on Oligodendrocyte Dysfunction

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

PHR: Lay summary: Alzheimer's Disease, a serious brain disorder, needs better treatment methods. This project is about studying a special group of brain's immune cells that may become old and not work properly, which could make Alzheimer's worse. We aim to learn more about these cells and see if getting rid of them can help slow down Alzheimer's. We'll use a special kind of lab mouse to help with this. If this works, we could learn how Alzheimer's develops and potentially find new ways to treat it by focusing on these old cells.

PI_NAMEs: YOUSEFZADEH, MATTHEW J;ZHU, YI  (contact)

PROJECT_TERMS: 3xTg-AD mouse;Ablation;Advanced Development;Aging;aging related disease;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Biologic Characteristic;Biology;Brain;Brain Diseases;Cell Aging;Cell Membrane Proteins;Cell Physiology;Cells;Cognition;Cognitive;Data;Deterioration;Development;digital;Diphtheria Toxin;Disease;Disease associated microglia;Disease Marker;Disease Progression;Enterobacteria phage P1 Cre recombinase;Estrogen Receptors;Excision;Family;Functional disorder;Genes;glycoprotein NMB;Healthcare Systems;hyperphosphorylated tau;Immune;Impairment;improved;innovation;insight;Investigation;Learning;Link;LoxP-flanked allele;Mediating;Methods;Microglia;mouse model;Mus;nano-string;Natural Immunity;Neurites;Neurodegenerative Disorders;neuroinflammation;neurotoxic;normal aging;novel;old mice;Outcome Study;Pathologic;Patients;Phenotype;Physiological;Pilot Projects;Play;preservation;prevent;Preventive;Production;promoter;protein aggregation;Proteins;Proteome;Proteomics;Research;risk variant;Role;senescence;senescence associated secretory phenotype;senescent cell;Senile Plaques;single-cell RNA sequencing;Site;Stimulus;Stress;stressor;Tamoxifen;tau-1;Testing;Therapeutic;therapeutic target;therapeutically effective;Tissues;tool;transcriptome;transcriptome sequencing;transcriptomics;Transgenic Mice;Transgenic Organisms;Up-Regulation;Work

PROJECT_TITLE: Investigating the Impact of Novel Senescent Microglia in Alzheimer's Disease Progression

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 AN-Z (55)]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: ANN ARBOR

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE Sepsis is a common and often deadly condition of organ dysfunction due to infection that is responsible for 1.7 million hospitalizations and an estimated 260,000 deaths annually in the United States; survivors of sepsis are often left debilitated due to muscle atrophy, which hinders independence and reduces quality of life. Unfortunately, other than physical rehabilitation, there are no treatments currently available for post-sepsis muscle atrophy because we do not understand how sepsis causes muscle atrophy. This project will study how the gut microbiome, the bacteria that live in the human intestinal tract, contributes to muscle atrophy during sepsis, with a goal of identifying new targets for treatment.

PI_NAMEs: BONGERS, KALE S (contact)

PROGRAM_OFFICER_NAME: CARIFI, EMILY FORAN

PROJECT_TERMS: Affect;Anabolism;Animal Model;Antibiotic Therapy;Antibiotics;Atrophic;Award;Bacteria;Biology;Blood;Calibration;career development;Cessation of life;Complement;Critical Care;Critical Illness;Data;Debility;Development;Development Plans;Doctor of Medicine;Doctor of Pharmacy;Doctor of Philosophy;Early Intervention;Ecology;endurance exercise;exercise capacity;experience;experimental study;Financial cost;Five-Year Plans;Foundations;Functional disorder;Future;Gene Expression;Germ-Free;Goals;gut bacteria;gut microbes;gut microbiome;gut microbiota;Health;Hospitalization;Human;Hypertrophy;Immune;improved;In Vitro;in vitro Model;in vivo;in vivo Model;Infection;Intestines;Investigation;Kale - dietary;Left;Lower Gastrointestinal Tract;Lung;Measures;Mediating;Mediator;Medical;Medicine;Mentors;Mentorship;Metabolic;Metabolic Pathway;metabolomics;Metagenomics;Michigan;microbial;microbiome;microbiome research;Morbidity - disease rate;mortality;mouse model;Mus;Muscle;Muscle Fibers;muscle form;muscle metabolism;muscle physiology;Muscle Weakness;Muscular Atrophy;Obesity;Organ;Outcome;Output;Pathogenesis;Patients;Pharmacotherapy;Physical Rehabilitation;Physicians;Play;post-doctoral training;prevent;Productivity;Publishing;Quality of life;Regulation;Research;Research Personnel;response;Risk;Role;Scientist;Secondary to;Sepsis;Severities;Skeletal Muscle;skeletal muscle wasting;skill acquisition;skills;success;Supplementation;Survivors;Swab;Techniques;Testing;Therapeutic;Tissues;Training;Translating;United States;Universities;Variant;Volatile Fatty Acids;Work

PROJECT_TITLE: The Role of the Gut Microbiome in Post-Sepsis Skeletal Muscle Atrophy

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: PITTSBURGH

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE This study was one of the first to demonstrate that cerebral amyloid deposition precedes cognitive decline by as much as 10-15 years. There appears to be great variability in the time from becoming amyloid positive until cognitive decline. Longitudinal studies, such as this one, which has been going on for 15 years, provide a unique opportunity to characterize the progression to Alzheimer’s disease.

PI_NAMEs: AIZENSTEIN, HOWARD J (contact);VILLEMAGNE, VICTOR LUIS

PROGRAM_OFFICER_NAME: WAGSTER, MOLLY V

PROJECT_TERMS: abeta deposition;Acceleration;Address;Age;age difference;age effect;age related;Aging;aging brain;aging process;Alzheimer's Disease;Amyloid;Amyloid beta-Protein;Amyloid deposition;Atrophic;Biological Markers;Blood Vessels;Brain;Cerebrovascular Disorders;cerebrovascular imaging;Cerebrum;Chronology;Clinical;Cognition;Cognitive;cognitive performance;cognitive testing;cohort;Deposition;Disease;follow-up;Functional disorder;Functional Magnetic Resonance Imaging;Genetic;Genetic Risk;Goals;gray matter;Hippocampus;Image;imaging study;Impaired cognition;Impairment;improved;Individual;Individual Differences;information processing;Longitudinal Studies;machine learning model;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Measures;medial temporal lobe;Mediating;memory encoding;Microvascular Dysfunction;Modeling;Morphology;MRI Scans;Nerve Degeneration;neural;Noise;older adult;Outcome;Participant;Positron-Emission Tomography;pre-clinical;processing speed;recruit;Risk;Risk Factors;Role;Signal Transduction;System;tau Proteins;Tauopathies;Testing;Time;Visit;White Matter Hyperintensity;Work;β-amyloid burden

PROJECT_TITLE: Roles of Gray Matter Brain Aging and Small Vessel Disease in AD Pathophysiology

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: Project narrative RO1 Disrupted immune responses contribute to aging and development of Alzheimer’s disease. Identification of critical metabolic pathways that regulate immune responses may lead to novel therapeutic approaches. The research objective of this proposal is to test whether metabolic reprogramming can prevent/reverse cognitive decline in aging and in models of Alzheimer’s disease.

PI_NAMEs: ANDREASSON, KATRIN I. (contact)

PROGRAM_OFFICER_NAME: MARIC, MAJA

PROJECT_TERMS: Ablation;Age;age acceleration;age related;age related neurodegeneration;Age-associated memory impairment;aged;Aging;aging brain;aging related;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease risk;Area;Bioenergetics;Blood;Brain;Cell Aging;Cell Lineage;Cell Physiology;Cell Reprogramming;Cells;Cellular Metabolic Process;Chronic;Cognitive aging;conditional knockout;Coupled;Data;Dementia;Development;Dinoprostone;Disease;Encephalitis;Energy Metabolism;Enrollment;Environment;Functional disorder;Genes;Genetic;genome wide association study;glial activation;Glucose;Glycogen;glycogen metabolism;Glycolysis;GTP-Binding Proteins;GYS1 gene;hallmarks of aging;Hematopoietic Stem Cell Transplantation;High Prevalence;Hippocampus;Homeostasis;Human;Human Genetics;Human Genome;Immune;immune activation;immune function;Immune response;Immune system;Immunotherapy;Impaired cognition;Infection;Inflammation;Inflammatory;Inflammatory Response;Link;Literature;Macrophage;Maintenance;Malignant Neoplasms;Mediating;Memory Loss;Metabolic;Metabolic Pathway;Metabolism;Microglia;misfolded protein;Mitochondria;mitochondrial metabolism;monocyte;mouse model;Mus;Myelogenous;Myeloid Cells;Neurons;novel;novel therapeutic intervention;Pathology;Pathway interactions;Peptides;Peripheral;Phagocytes;pharmacologic;Phenocopy;Phenotype;Plasma;prevent;Process;PTGS2 gene;receptor;Receptor Signaling;Rejuvenation;Research;Respiration;response;Risk Factors;Role;Signal Pathway;Signal Transduction;systemic inflammatory response;tau Proteins;Testing;Variant

PROJECT_TITLE: Reprogramming myeloid cell metabolism to prevent cognitive aging and Alzheimer's Disease


ED_INST_TYPE: OVERALL MEDICAL

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_NAME: RUSH UNIVERSITY MEDICAL CENTER

PHR: PROJECT NARRATIVE This project addresses an important research priority in the field of Alzheimer’s disease and related dementias, about a novel epigenetic mechanism for which there is currently little data in both blood and brain and across race, to link vascular risk factors such as diabetes to dementia, cognitive decline, and postmortem brain pathology in older White and Black persons. Because vascular risk factors are common and modifiable with treatments and lifestyle approaches, this project is likely to have a high and sustained impact on improving public health.

PI_NAMEs: ARVANITAKIS, ZOE  (contact)

PROGRAM_OFFICER_NAME: YAO, ALISON Q

PROJECT_TERMS: Address;Affect;Age;Aging;aging brain;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease pathology;Alzheimer's disease related dementia;Alzheimer's disease risk;Amyloid;Autopsy;base;Black Populations;Black race;black women;Blood;Blood Pressure;blood resource;Blood specimen;Blood Vessels;Body mass index;Brain;Brain Pathology;brain tissue;Cause of Death;cell free DNA;Cerebrovascular Disorders;cerebrovascular pathology;Chemicals;Chronic;Clinical;clinical care;Clinical Data;Cognition;Cognitive;cohort;Cohort Studies;Collection;Communities;Cytosine;Data;Dementia;dementia care;dementia risk;demethylation;Diabetes Mellitus;Disabling condition;Disease;DNA;Epigenetic Process;epigenome;experimental study;Freezing;Gene Activation;Genetic Transcription;Genome Mappings;genome-wide;Genomic DNA;Glycosylated hemoglobin A;Goals;Human;Impaired cognition;improved;Individual;Intervention;Knowledge;Life Style;Link;Measures;men;Methods;minimally invasive;Modification;nano;Neurofibrillary Tangles;neuropathology;novel;Older Population;Participant;Pathologic;Pathology;Patients;Performance;Persons;Pharmaceutical Preparations;Phenotype;population health;Prefrontal Cortex;Prevention;primary outcome;Process;Public Health;Race;racial minority population;racial population;Research;Research Priority;Resources;response;Role;Science;Scientific Advances and Accomplishments;seal;secondary analysis;Sensitivity and Specificity;Serum;sex;sex as a biological variable;Societies;Techniques;Tissue Sample;Tissues;tool;Validation;Vascular Diseases;vascular factor;vascular risk factor;White Women

PROJECT_TITLE: The role of blood and brain 5-hydroxymethylcytosine in linking vascular risk factors to ADRD in older White and Black persons


NIH_SPENDING_CATS: Autoimmune Disease;Building Research Capacity at Institutions with Limited NIH Funding;Crohn's Disease;Digestive Diseases;Inflammatory Bowel Disease;Liver Disease

ORG_CITY: CHARLESTON

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PI_NAMEs: ENGEVIK, AMY C (contact)

PROGRAM_OFFICER_NAME: KOVBASNJUK, OLGA NIKOLAEVNA

PROJECT_TERMS: Actins;Acute;Address;Adhesions;Alkaline Phosphatase;Animal Model;Animals;Antigens;Apical;Biopsy;cellular microvillus;Centers of Research Excellence;Chronic;Colitis;Colon;Complex;Data;density;Digestive System Disorders;Disease;Drug Metabolic Detoxication;Enzymes;Epithelial Cells;Epithelium;Functional disorder;functional loss;Gene Expression;Gene Proteins;gut inflammation;Health;Height;Homeostasis;Human;Inflammation;Inflammatory;Inflammatory Bowel Diseases;intestinal epithelium;Intestines;Liver diseases;member;Modeling;Molecular Motors;murine colitis;Mus;Myosin ATPase;novel therapeutics;Organoids;Outcome;Pathway interactions;Patients;Play;Protein phosphatase;Proteins;Quality of life;Research;Role;Signal Transduction;Stimulus;Structure;T-Lymphocyte;trinitrobenzene sulfonic acid induced colitis;Work

PROJECT_TITLE: Elucidating the role of Myosin 5b in intestinal inflammation


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: This proposal aims to generate a histologically-validated map of twelve hippocampal subregions for neuroimaging, a critical step towards determining Alzheimer’s disease pathogenesis and developing novel therapeutic interventions to halt Alzheimer’s disease progression. This project will use a cell based approach from histology to make a cellularly-validated atlas in FreeSurfer that will be applied to other existing in vivo datasets.

PI_NAMEs: AUGUSTINACK, JEAN  (contact)

PROGRAM_OFFICER_NAME: GRAY, ERIN EMILY

PROJECT_TERMS: Affect;Aging;aging brain;alveus;Alzheimer's Disease;Anatomy;Atlases;Atrophic;automated segmentation;Autopsy;Biological Markers;Brain;brain tissue;Cell Size;Cells;clinically relevant;cohort;Computer software;Confusion;connectome;Data;Data Set;dentate gyrus;Diameter;Disease Progression;fimbria;Future;Goals;Guidelines;healthy aging;Hippocampal Formation;hippocampal pyramidal neuron;hippocampal subregions;Hippocampus;Histologic;Histology;Human;Image;Imaging Device;improved;in vivo;in vivo imaging;Individual;Label;Longitudinal Studies;Magnetic Resonance Imaging;Manuals;Maps;Measures;Microanatomy;Modeling;Molecular;Nature;Neuroanatomy;neuroimaging;neuronal patterning;Neurons;normal aging;novel;novel therapeutic intervention;open source;Pathogenesis;Pattern;Population;Positioning Attribute;pre-clinical;Protocols documentation;Pyramidal Cells;Reporting;Reproducibility;Resolution;ROC Curve;Scanning;Specificity;Stains;success;Testing;Therapeutic Studies;Tissue Banks;tool;ultra high resolution;Update;Work

PROJECT_TITLE: Establishing cellular-validated standards for parcellating hippocampal subfields in aging and Alzheimer's disease


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Cardiovascular;Dementia;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Neurodegenerative;Neurosciences;Nutrition;Physical Activity;Prevention

ORG_CITY: DURHAM

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE Clinical, pathological and epidemiological evidence clearly show overlap between cardiovascular and Alzheimer’s diseases caused by a critical genetic link: the apolipoprotein E gene. We will develop novel photon counting cardiac CT imaging and use it in combination with brain MR imaging and behavior assessments to study the impact of APOE genotype in mouse models and to provide data on phenotypic differences in these mice when exposed to a high fat/high sugar diet and the role of exercise in protecting against Alzheimer’s and cardiovascular diseases.

PI_NAMEs: BADEA, CRISTIAN T (contact)

PROGRAM_OFFICER_NAME: TSAP, LEONID V

PROJECT_TERMS: 3-Dimensional;Abbreviations;Address;Adoption;Affect;Aging;Algorithms;Alleles;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease risk;Animal Experiments;Animal Model;Apolipoprotein E;apolipoprotein E-3;Arterial Fatty Streak;Atherosclerosis;Behavior;Behavior assessment;behavioral study;Biological Markers;Brain;brain based;brain magnetic resonance imaging;Brain region;Cardiac;cardiac plaque;Cardiovascular Diseases;cardiovascular risk factor;Cardiovascular system;Cause of Death;Characteristics;Clinical;Cognitive;combat;comparison control;computerized data processing;Data;data acquisition;deep learning;detector;Development;Diet;Dimensions;Dose;Environmental Impact;environmental stressor;Epidemiology;Exercise;exercise intervention;exercise regimen;Exposure to;Fatty acid glycerol esters;Foundations;Generations;Genes;Genetic;Genetic Risk;Genotype;Heart Diseases;heart function;heart imaging;Human;human subject;Image;Imaging Device;imaging modality;Immune response;Impaired cognition;improved;in vivo;insight;Intervention;Link;Magnetic Resonance;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Malignant Neoplasms;Measurement;Measures;Methodology;Methods;Modeling;Monitor;Morphologic artifacts;mouse model;Mouse Strains;Mus;Myocardial perfusion;Names;Nitric Oxide Synthase;Noise;non-invasive imaging;NOS2A gene;novel;Outcome;Oxidation-Reduction;Pathologic;Performance;Phenotype;photon-counting detector;Photons;Physiologic Monitoring;pre-clinical;Pre-Clinical Model;preclinical imaging;preclinical study;predictive modeling;Process;Protein Isoforms;Protocols documentation;prototype;reconstruction;Research;resilience;resilience in aging;Resolution;response;Risk;Risk Factors;Role;Scanning;sedentary lifestyle;simulation;spectral distortion;sugar;System;Technology;Testing;Time;tool;X-Ray Computed Tomography

PROJECT_TITLE: Cardiac photon counting CT and its application in studying interactions between Alzheimer's and heart disease


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Health Services;Neurodegenerative;Patient Safety

ORG_CITY: Oakland

ORG_NAME: KAISER FOUNDATION RESEARCH INSTITUTE

PHR: Project Narrative Patient-centered care should include medical treatment to achieve goals of care, but not medicines that are either likely to be harmful or unhelpful. Deprescribing is the process of reducing or stopping the use of inappropriate medications or medications unlikely to be beneficial supervised by a health-care professional. We will develop and test a novel tool and methods to generate adequate safety evidence to support thoughtful and effective deprescribing using a new data-based approach.

PI_NAMEs: BAYLISS, ELIZABETH A (contact);BOYD, CYNTHIA MELINDA

PROGRAM_OFFICER_NAME: SALIVE, MARCEL

PROJECT_TERMS: Address;adjudication;Adrenergic beta-Antagonists;Adverse drug event;Aging;Allergic Reaction;Alzheimer's disease patient;Alzheimer's disease related dementia;Ambulatory Care;Awareness;Binding;Caregivers;Caring;Characteristics;Clinical;Cluster randomized trial;cognitive change;cohort;Colorado;Data;Data Set;data warehouse;Dementia;Diagnosis;Drug Interactions;drug withdrawal;Education;effectiveness evaluation;Electronic Health Record;Equilibrium;Event;experience;Family;Family member;Fright;gastrointestinal;Goals;Health Professional;high risk;Individual;Intervention;Knowledge;Measures;Medical;Medical Records;Medication Management;Methodology;Methods;Modeling;Monitor;multiple chronic conditions;novel;older adult;overtreatment;Patient-Centered Care;Patients;Persons;Pharmaceutical Preparations;Pharmacy facility;Physiological;Polypharmacy;Population;population based;Pragmatic clinical trial;Predictive Factor;Prevalence;primary care clinician;Process;Reaction;Recommendation;Recurrence;Reflux;Reporting;Research;Risk;Safety;Sampling;Science;secondary analysis;Serious Adverse Event;side effect;study population;Symptoms;Tachycardia;Testing;Text;text searching;tool;virtual;Withdrawal;Work

PROJECT_TITLE: Generating Evidence on Deprescribing Safety

STUDY_SECTION: HSOD

STUDY_SECTION_NAME: Health Services Organization and Delivery Study Section[HSOD]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Rehabilitation

ORG_CITY: GAINESVILLE

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE: Cognitive dysfunction associated with aging and Alzheimer's disease is a significant and growing public health problem. The proposed research will determine the utility of electrical stimulation of the vagus nerve for remediating neurobiological and cognitive impairments in aging, as well as Alzheimer's disease-like neuropathology. This work will be significant because it will provide the foundation for using vagus nerve stimulation as a therapy for treating age-related cognitive impairments.

PI_NAMEs: BIZON, JENNIFER LYNN (contact);SETLOW, BARRY

PROJECT_TERMS: Acute;age related;age related changes;Age-associated memory impairment;aged;Aging;aging brain;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease pathology;Alzheimer's disease patient;Animals;Attenuated;Biochemical;Brain;Brain region;Central Nervous System;Chronic;clinical diagnosis;Cognition;Cognitive;cognitive benefits;Cognitive deficits;cognitive function;cognitive performance;cytokine;Data;Dependovirus;Drug Targeting;Electric Stimulation;Electrophysiology (science);Epilepsy;Equilibrium;executive function;Exhibits;experimental study;Foundations;GABA Receptor;Glutamate Receptor;glutamatergic signaling;Health;Hippocampus;Homeostasis;Human;human old age (65+);human subject;Impaired cognition;improved;Individual;Inflammation;Inflammatory;inflammatory marker;instrumental activity of daily living;Intervention;Intractable Epilepsy;Learning;Link;Mediating;meetings;Mental Depression;middle age;Modeling;Molecular;Nature;Nerve Degeneration;neural;Neurobiology;neuropathology;novel;older adult;Outcome;Pathology;Peripheral;Population;pre-clinical;Predisposition;Prefrontal Cortex;prevent;Public Health;Publishing;rapid growth;Rattus;Regimen;remediation;Reporting;Research;Risk;Rodent;side effect;Signal Transduction;Signaling Protein;Structure;Synapses;tau aggregation;tau expression;tau Proteins;Testing;Therapeutic;Translating;treatment group;vagus nerve stimulation;Work

PROJECT_TITLE: Mechanisms and therapeutic potential of vagus nerve stimulation in aging and Alzheimer’s disease

STUDY_SECTION: LAM

STUDY_SECTION_NAME: Neurobiology of Learning and Memory Study Section[LAM]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Stroke;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: CORAL GABLES

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

PHR: Greenness, or the lack of greenness, has the potential to touch every life. Therefore, longitudinal research on greenness has the potential for tremendous public health impact, particularly given the accumulating evidence on the relationship of greenness to chronic diseases. Research on neighborhood greenness and health suggests that benefits can be obtained even with relatively small increases in greenness. Findings that longitudinal greenness exposure protects against cognitive decline, vascular outcomes and/or Alzheimer’s disease, would further support the role of increased greenness in promoting successful aging.

PI_NAMEs: BROWN, SCOTT CHARLES (contact);RUNDEK, TATJANA ;SZAPOCZNIK, JOSE

PROGRAM_OFFICER_NAME: NGUYEN, EMERALD THAI HAN

PROJECT_TERMS: adjudication;Affect;Age;Age-associated memory impairment;Aging;aging population;Air Pollution;Alzheimer's Disease;Alzheimer's disease related dementia;Antiinflammatory Effect;apolipoprotein E-4;archived data;behavior measurement;Behavioral;Biological;Biological Markers;Black Populations;Blood Pressure;Blood Vessels;Body mass index;Brain;Brain imaging;Brain Infarction;cardiometabolism;cerebrovascular;Cessation of life;Characteristics;Chronic Disease;Cognition;Cognitive;Cognitive aging;cognitive disability;cognitive performance;cognitive testing;cohort;Collaborations;Complex;cost;Crime;Data;data access;deprivation;Diabetes Mellitus;Education;Enabling Factors;Environmental Risk Factor;Epidemiologist;ethnic minority;Ethnic Origin;Etiology;Event;experience;Exposure to;fasting glucose;follow-up;functional disability;Geographic Locations;Health;Heart Diseases;High Prevalence;Hispanic Populations;Hyperlipidemia;Hypertension;IL6 gene;Imagery;imaging biomarker;Impaired cognition;Income;Individual;Inflammation;Inflammatory;interest;Interleukin-6;Life;Link;longitudinal design;Magnetic Resonance Imaging;Measures;Mediating;Methods;microbiome;mild cognitive impairment;multi-ethnic;multi-racial;Myocardial Infarction;Neighborhoods;Neurologist;Not Hispanic or Latino;novel;older adult;Outcome;Participant;Pathway interactions;Performance;Physical activity;Pollution;Population;prevent;prospective;Prospective cohort;protective effect;protective factors;Psychologist;Public Health;Quality of life;Race;racial minority;Research;Research Personnel;resilience;Resolution;Risk;Risk Factors;Role;Sampling;Sampling Studies;Scientist;sex;social;Social support;socioeconomics;Stroke;stroke outcome;Testing;Thick;Time;TNFRSF1A gene;Touch sensation;Trees;waist circumference;walkability;White Matter Hyperintensity

PROJECT_TITLE: Greenness, Cognitive Performance and Vascular Outcomes in the NOMAS Study

STUDY_SECTION: NAME

STUDY_SECTION_NAME: Neurological, Aging and Musculoskeletal Epidemiology Study Section[NAME]