NIH_SPENDING_CATS: Cancer

ORG_CITY: SAN DIEGO

ORG_DEPT: BIOLOGY

ORG_NAME: SAN DIEGO STATE UNIVERSITY

PHR: PROJECT NARRATIVE San Diego State University’s Advancing Cancer Careers for ExceLlence (ACCEL) Program, in partnership with University of California San Diego (UCSD) Moores Cancer Center, will provide 70 SDSU postdoctoral fellows and graduate students each year with a coordinated and innovative array of resources to support excellence, inclusion and transformation of the cancer research science force. ACCEL will leverage existing infrastructure and develop new programming to a) expand and strengthen the pipeline of underrepresented (UR) scholars pursuing cancer research; and b) broaden SDSU’s capacity to support and advance UR pre- and postdoctoral cancer research scholars.

PI_NAMEs: LEWISON, REBECCA  (contact)

PROGRAM_OFFICER_NAME: BARFIELD-STEWARD, WHITNEY

PROJECT_TERMS: Academia;Address;Advanced Malignant Neoplasm;anti-cancer research;Area;Calendar;California;Cancer Center;cancer health disparity;Cancer health equity;Cancer Science;career;Career Choice;career development;career networking;Caring;catalyst;Collaborations;commune;Communities;community building;Coupled;course development;Critical Thinking;Dedications;Development;doctoral student;Educational process of instructing;Educational workshop;Environment;experience;Faculty;Feeling;Fostering;Funding;Geography;graduate student;Grant;improved;Individual;Infrastructure;innovation;Institution;Knowledge acquisition;Lead;Learning;Malignant Neoplasms;Mentors;Mentorship;Methodology;National Cancer Institute;peer;Postdoctoral Fellow;pre-doctoral;Preparation;Program Development;programs;Research;Resources;Scholarship;Science;Scientist;Services;skill acquisition;skills;Strategic Planning;Structure;Students;Training;Training Support;Underrepresented Students;Universities;university student;Writing

PROJECT_TITLE: San Diego State University Advancing Cancer Careers for ExceLlence (ACCEL)


ADMINISTERING_IC: EY

ARRA_FUNDED: N

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Bioengineering;Cardiovascular;Clinical Research;Data Science;Eye Disease and Disorders of Vision;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Hypertension;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: ORONO

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF MAINE ORONO

ORG_STATE: ME

PHR: RELEVANCE (See instructions): Open angle glaucoma is a leading cause of irreversible blindness worldwide with significant disparities in prevalence, incidence, and progression depending on gender, race, and socio-economic status. The proposed research is relevant to public health because quantifying the relative weight of intraocular pressure and blood pressure in the disease process of each individual and identifying characteristics that put people at-risk for glaucoma, particularly racial and ethnic minorities, will promote better methods to

PI_NAMEs: GUIDOBONI, GIOVANNA  (contact);HARRIS, ALON

PROGRAM_OFFICER_NAME: GAO, JAMES

PROJECT_TERMS: Age;Algorithms;Biomechanics;Blindness;Blood flow;Blood Pressure;Blood Vessels;Caring;Characteristics;Clinic;Clinical Data;clinical practice;Collection;Computer Models;computer science;Country;Coupling;Data;Data Analyses;Data Analytics;Data Set;demographic disparity;Devices;Diagnosis;Differential Equation;Disease;Disparity;diverse data;Economic Burden;Ensure;Equity;ethnic minority;Evaluation;Eye;Feedback;Formulation;Gender;Glaucoma;Goals;Health;health communication;Healthcare Systems;hemodynamics;Heterogeneity;heterogenous data;high dimensionality;Hypertension;Hypotension;improved;Incidence;Individual;innovation;Institution;Instruction;instrument;Interview;large scale data;Mathematics;Measurement;Medical;Methods;Modeling;multi-ethnic;multidisciplinary;multiple datasets;Nature;novel;Open-Angle Glaucoma;Ophthalmology;Outcome;Outcomes Research;Output;Patients;Persons;Pharmaceutical Preparations;Physics;Physiologic Intraocular Pressure;Physiological;Physiology;Populations at Risk;Prevalence;prevent;Process;Property;Public Health;Race;racial minority;Research;Retina;Risk;Risk Factors;Sample Size;Science;Series;simulation;Societies;Socioeconomic Status;spatiotemporal;Statistical Methods;statistics;Stress;Structure;Time;tool;transfer learning;translational framework;Uncertainty;unnecessary treatment;usability;vector;virtual reality simulator;Weight

PROJECT_TITLE: SCH: SEEthroughGLAUCOMA: Smart Eye Emulator (SEE) to study glaucoma risk factors

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-VH-N(50)R]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Biomedical Imaging;Brain Disorders;Drug Abuse (NIDA only);Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: Narrative Stimulant use and abuse continue to be on the rise, yet we know little about the initial molecular changes that occur in the brain with repeated drug use. In this project, we will employ whole-brain multimodal imaging to investigate how repeated exposure to two classes of stimulant drugs alters excitatory and inhibitory dopamine receptor signaling and trafficking over time. The results from this study will provide insight into the timeline of receptors adaptations due to drug exposure and shed a light on the mechanisms that may lead to addiction.

PI_NAMEs: SANDER, CHRISTIN Y. (contact)

PROGRAM_OFFICER_NAME: VEMURI, KIRAN R V

PROJECT_TERMS: Acute;addiction;Address;Affect;Amphetamines;Animal Model;antagonist;Behavior;Brain;Chronic;Complex;Data;Development;Dopamine;Dopamine D1 Receptor;Dopamine D2 Receptor;Dopamine Receptor;dopamine system;dopamine transporter;Dopamine Uptake Inhibitors;Drug abuse;Drug Addiction;Drug Exposure;Drug Kinetics;Drug Sensitization;Drug usage;Drug user;Equilibrium;Evolution;Experimental Designs;Exposure to;extracellular;Functional Magnetic Resonance Imaging;Goals;Hour;Image;imaging study;In Vitro;in vivo;Injections;innovation;insight;Knowledge;Lead;Maintenance;Measures;Membrane;Methodology;Methods;Molecular;Multimodal Imaging;neurobiological mechanism;Neurobiology;neuroimaging;Neuropharmacology;nonhuman primate;Outcome;Pathogenesis;Pharmaceutical Preparations;pharmacologic;Play;Positron-Emission Tomography;prevent;Prevention;psychostimulant;Raclopride;radiotracer;receptor;receptor internalization;receptor recycling;Receptor Signaling;Recovery;Recycling;Reporting;response;Ritalin;Role;Sensory Receptors;Signal Transduction;Stimulant;stimulant abuse;stimulant exposure;stimulant use;Substance Use Disorder;Synapses;Testing;Time;timeline;trafficking;translation to humans;uptake

PROJECT_TITLE: Stimulant-induced excitatory and inhibitory dopamine receptor signaling and trafficking

STUDY_SECTION: MCNP

STUDY_SECTION_NAME:
Molecular and Cellular Neuropharmacology Study Section
[MCNP]


ADMINISTERING_IC: AA

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse;Underage Drinking

ORG_CITY: TEMPE

ORG_DEPT: PSYCHOLOGY

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

ORG_STATE: AZ

PHR: PROJECT NARRATIVE Alcohol use and disorders are prevalent and associated with significant personal, interpersonal, and societal costs. Relevant to NIH's public health mission, the proposed study investigates genetic influences on the progression and trajectories of alcohol use from late childhood to adolescence, examines the role of childhood precursors (impulsivity, externalizing, and internalizing symptoms) in the pathways of genetic risk to alcohol use, and identifies cultural-contextual risk and protective factors that moderate genetic risk among racially- ethnically diverse youth. Findings have strong potential to inform culturally-tailored and personalized early prevention programs aimed at reducing alcohol problems and related health disparities.

PI_NAMEs: SU, JINNI  (contact)

PROGRAM_OFFICER_NAME: ZHA, WENXING

PROJECT_TERMS: 10 year old;Acceleration;Adolescence;Adolescent;Adult;African American;Age;Alcohol abuse;Alcohol consumption;alcohol risk;alcohol use disorder;alcohol use initiation;Alcohols;American;Behavior;Behavioral Genetics;Black race;Brain;Buffers;Cause of Death;Child;Child Health;Child Rearing;Childhood;cognitive development;Complex;contextual factors;cultural values;Data;deter alcohol use;Development;Disease;early alcohol use;Environment;Environmental Risk Factor;Equation;ethnic diversity;ethnic minority population;Etiology;European;European ancestry;gene environment interaction;Genes;Genetic;Genetic Risk;genome-wide;genomic data;Health Disparities Research;health disparity;high risk;Hispanic;Human;Impulsivity;Individual;insight;Intervention;intervention program;Latinx;Link;Mediating;Mission;Modeling;Outcome;Pathway interactions;peer;perceived discrimination;person centered;phenotypic data;Polygenic Traits;Population;Population Heterogeneity;Prevention;Prevention program;Process;prospective;protective factors;Puberty;Public Health;racial discrimination;racial diversity;racial minority population;Research;Risk;Risk Factors;Role;Sampling;Science;Sex Differences;Shapes;societal costs;Stressful Event;substance use;Survival Analysis;Symptoms;Temperament;Testing;trait;Twin Multiple Birth;underage drinking;United States;United States National Institutes of Health;Youth

PROJECT_TITLE: Gene-Environment Interplay and Alcohol Use among Racially-Ethnically Diverse Youth: A Developmentally and Culturally Informed Approach

STUDY_SECTION: LHB

STUDY_SECTION_NAME: Lifestyle and Health Behaviors Study Section[LHB]


ADMINISTERING_IC: HD

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;HIV/AIDS;Health Services;Infectious Diseases;Pediatric;Pediatric - AIDS;Prevention;Women's Health Research

ORG_CITY: MOROGORO

ORG_COUNTRY: TANZANIA U REP

ORG_FIPS: TZ

ORG_NAME: CENTRE OF EXCELLENCE IN HEALTH MONITORING AND EVALUATION

ORG_ZIPCODE: P.o Box 2

PHR: NARRATIVE Tailored implementation strategies are urgently needed to increase the uptake of highly effective HIV prevention such as pre-exposure prophylaxis (PrEP) and HIV self-testing (HIVST) among adolescent girls and young women (AGYW) in sub-Saharan Africa. In this study, we will scale several pharmacy-based models for PrEP and HIVST delivery in five areas of Lake Zone, Tanzania and will evaluate implementation and effectiveness outcomes among pharmacies and AGYW. Trainees completing a Certificate in Implementation Science will enhance the research, which will provide guidance about whether pharmacy-based distribution of PrEP and HIVST is an effective strategy for decreasing the incidence of HIV among AGYW.

PI_NAMEs: ANASEL, MACKFALLEN GILIADI (contact);BERTOZZI, STEFANO M.;PROSPER, NJAU

PROGRAM_OFFICER_NAME: LEE, SONIA S

PROJECT_TERMS: adolescent HIV prevention;Adoption;Africa;Africa South of the Sahara;Age;AIDS prevention;Area;Awareness;Businesses;California;Caring;certificate program;Clinic;Clinical Research;cohort;Collaborations;Communities;Contraceptive Agents;Contraceptive methods;Cost Sharing;Counseling;Coupled;Dapivirine;Data;design;Development;effectiveness outcome;effectiveness study;effectiveness/implementation study;empowerment;Ensure;Environment;epidemic response;evidence base;Face;Female Adolescents;Friends;Future;girls;Goals;Government;Grant;Health;Health care facility;Health Services;Health system;high-risk adolescents;HIV;HIV Infections;Household;implementation evaluation;implementation framework;implementation outcomes;implementation research;implementation science;implementation strategy;Incentives;Incidence;Infection;Infrastructure;Injectable;innovation;Knowledge;Lead;Location;Maintenance;Modeling;Modernization;Oral;Outcome;performance site;Pharmaceutical Preparations;Pharmacy facility;pill;Pilot Projects;Policies;Policy Maker;Population;pre-exposure prophylaxis;Prevention Research;Prevention strategy;Private Sector;Privatization;programs;Prospective cohort;public-private partnership;randomized trial;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Records;Reproductive Health Services;Research;Research Personnel;Resources;San Francisco;self testing;Services;sexual and reproductive health;Sexuality;Site;social stigma;success;Surveys;Tanzania;Time;Training;Training Programs;unintended pregnancy;Universities;uptake;vulnerable adolescent;Woman;Women's study;young woman;Youth

PROJECT_TITLE: Making women's options for HIV prevention in Tanzania accessible and joining implementation science capacity building (MWOTAJI)


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Breast Cancer;Cancer;Orphan Drug;Rare Diseases;Women's Health Research

ORG_CITY: LA JOLLA

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: Project Narrative The proposed research aims to fill an unmet clinical need in treating aggressive cancers such as colon, pancreatic, and breast. We found that Integrin Alpha V (ITGAV) is necessary for the survival of these cancers and that a novel pocket on its structure can be targeted with a drug. Additionally, we will investigate the complex signaling controlled by ITGAV to propose combinational therapies and create new therapeutic strategies to treat these cancers.

PI_NAMEs: MATTSON, NICOLE  (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: Acute Lymphocytic Leukemia;Acute Myelocytic Leukemia;Advanced Malignant Neoplasm;Apoptosis;Award;beta catenin;Binding;Biological;Biological Assay;Biology;biomarker discovery;Breast;cancer cell;Cancer Model;cancer survival;Cause of Death;Cell Cycle;Cell Cycle Regulation;Cell Death Induction;cell killing;Cell surface;Cells;Cessation of life;Cities;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Code;Collaborations;Colon;Colon Carcinoma;Combined Modality Therapy;comparison control;Complex;Computer Models;CRISPR screen;Cutaneous T-cell lymphoma;Data;density;design;Docking;Drug Targeting;effective therapy;Energy Transfer;Essential Genes;FDA approved;Fellowship;Genes;Goals;high throughput screening;Impairment;improved;in silico;In Vitro;inhibitor;Integrin alphaV;Integrin beta Chains;Integrins;Invaded;Knock-out;Laboratories;lead candidate;Liquid substance;Machine Learning;Malignant Breast Neoplasm;Malignant neoplasm of pancreas;Malignant Neoplasms;MAPK10 gene;Mass Spectrum Analysis;mathematical model;Measurable;Methods;migration;Mitogen-Activated Protein Kinases;Modeling;Monitor;Mutate;Mutation;nemo-like kinase;new therapeutic target;novel;novel therapeutic intervention;novel therapeutics;Oncogenic;Pancreas;Patients;Pharmaceutical Preparations;Phase;Phosphotransferases;Play;Postdoctoral Fellow;pre-doctoral;predictive modeling;prevent;Proteomics;Research;Research Project Grants;Role;Scanning;Scientist;Signal Pathway;Signal Transduction;skills;small molecule;Solid;Solid Neoplasm;statistics;Structure;System;Techniques;Technology;Therapeutic;Time;Training;Translational Research;triple-negative invasive breast carcinoma;tumor;United States;Validation;Western Blotting;Work

PROJECT_TITLE: Targeting a Novel Pocket on ITGAV


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Aging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Disability Research;Neurodegenerative;Neurosciences;Parkinson's Disease

ORG_CITY: SAINT LOUIS

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE This project seeks to harness the power of music and singing to enhance walking ability in people with Parkinson disease. We think that mental (i.e. imagined) singing while walking will help people walk faster with more stable gait while walking to music will help people walk faster but will less stability. Our studies will help us understand the best ways to use singing and music to help people walk more effectively and maintain their mobility and independence, and we will learn how use of these methods influences the brain.

PI_NAMEs: EARHART, GAMMON M. (contact)

PROGRAM_OFFICER_NAME: CHEN, WEN G

PROJECT_TERMS: Acute;Address;Age;Aging;Area;Brain;Cerebellum;comparison control;cost;Coupling;Cues;daily functioning;Development;disability;effective therapy;evidence base;Exhibits;experience;Fingers;Foundations;Functional Magnetic Resonance Imaging;Future;Gait;Gait abnormality;Gait speed;Goals;improved;Individual;innovation;Intervention;Intervention Studies;Learning;Length;Life;Magnetic Resonance Imaging;Measures;Methods;mortality;Motor;Motor Cortex;Movement;Music;Neurodegenerative Disorders;novel;older adult;Parkinson Disease;Participant;Performance;Periodicity;Persons;physical therapist;Psyche structure;putamen;Quality of life;Randomized;response;Solid;Source;Speed;Techniques;Testing;Training;Treatment Efficacy;usability;Walking;walking performance;Work

PROJECT_TITLE: Sing for Your Saunter: Using Self-Generated Rhythmic Cues to Enhance Gait in Parkinson's


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

ORG_CITY: WEST LAFAYETTE

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: RELEVANCE (See instructions): Tobacco and mentholated e-cigarette flavors are widely available and using these products are considered  safer than traditional cigarette use. Toxicity and health effects of these flavors and what agents cause  those health effects are not known. This R00 proposes to perform short term and long-term effects of  exposure to menthol, mint, and tobacco flavored e-cigarettes on lungs and how the exposure affect pre-existing lung conditions.

PI_NAMEs: MUTHUMALAGE, THIVANKA MUDALIGE (contact)

PROGRAM_OFFICER_NAME: TYSON, FREDERICK L

PROJECT_TERMS: 3-Dimensional;Acute;Acute Lung Injury;acute toxicity;aerosolized;Aerosols;Affect;Air;Antitussive Agents;Asthma;BALB/cJ Mouse;Biological;Biological Markers;Bronchoalveolar Lavage Fluid;Cell Culture Techniques;Cells;Chemical Agents;Chemicals;Chemistry;Chronic;Chronic Obstructive Pulmonary Disease;cigarette smoke;cigarette smoking;combustible cigarette;combustible tobacco;comparative;Consumption;Data;Disease;Dose;Electronic cigarette;electronic liquid;Electronic Nicotine Delivery Systems;Epithelium;Eugenol;Evaluation;Exposure to;exposure to cigarette smoke;Female;Flavoring;Gases;Gene Expression Profiling;genotoxicity;Genus Mentha;Health;Health Benefit;Hematoxylin and Eosin Staining Method;Human;Ice;improved;In Vitro;in vivo;Inbred BALB C Mice;Inflammation Mediators;Instruction;Liquid substance;Long-Term Effects;Lung;Lung Diseases;male;Manuscripts;Mentha spicata;Menthol;mouse model;Mucous body substance;Mus;nano-string;New York;Nicotine;non-smoker;Outcome;Pathogenicity;Periodic acid Schiff stain method;Phase;Phenotype;Property;Proteomics;Public Health;Publications;Publishing;pulegone;Pulmonary Emphysema;Regulation;Research;respiratory;Respiratory Disease;response;Risk;Science;sex;Smoker;Societies;Stains;Structure of parenchyma of lung;symposium;System;therapeutic target;Tissues;Tobacco;tobacco flavor;Tobacco use;Toxic effect;toxicant;Toxicology;Update;vaping;vapor

PROJECT_TITLE: Pulmonary toxicological evaluation and chemical interactions of menthol, mint, and tobacco flavored e-cigarette products

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Cancer;Genetic Testing;Genetics

ORG_CITY: Hudson

ORG_NAME: GLC BIOTECHNOLOGY, INC.

ORG_STATE: OH

PHR: Narrative The objective of this SBIR Phase II project is to further develop a breakthrough TEE technology and validate TEE-based tests for clinical use.

PI_NAMEs: DENG, QIPAN  (contact);GUO, BAOCHUAN

PROGRAM_OFFICER_NAME: LOU, XING-JIAN

PROJECT_TERMS: Aftercare;Alleles;Biological Models;Blood;BRAF gene;cancer care;Cancer Detection;Cancer Patient;Clinical;clinical application;Codon Nucleotides;commercialization;companion diagnostics;cost;Detection;detection test;Development;Diagnostic tests;Dideoxy Chain Termination DNA Sequencing;digital;DNA;DNA Mutational Analysis;DNA Sequence;Drug Targeting;Effectiveness;Eligibility Determination;Epidermal Growth Factor Receptor;FDA approved;Foundations;Future;improved;innovation;KRAS2 gene;liquid biopsy;Malignant Neoplasms;Managed Care;Medicine;Methods;Monitor;Mutate;Mutation;Mutation Analysis;Mutation Detection;novel;Patients;Performance;Pharmaceutical Preparations;Phase;Plasma;Recovery;Reproducibility;Sampling;Serum;Small Business Innovation Research Grant;Specificity;Specimen;success;System;Systems Analysis;targeted treatment;Technology;technology platform;Testing;Tissue Sample;Tissues;tumor;Tumor Tissue;Validation;validation studies;Work

PROJECT_TITLE: Development of An Innovative TEE Technology for Mutation Detection


ADMINISTERING_IC: TR

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

ORG_CITY: Aurora

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative. The Colorado Clinical and Translational Sciences Institute’s T32 Post-Doctoral Program aligns with and supports the goals of NCATS to ensure that a diverse pool of highly trained scientists is available in adequate numbers to carry out the nation’s clinical and translational science research agenda. Our program is novel in that it expands the translational spectrum by recognizing the importance of shared, naturally occurring models of disease among animals and humans to push discovery. As such to meet these needs, we will prepare diverse interdisciplinary translational scientists involving both doctorally prepared clinicians (physicians (MD), pharmacists (PharmD), physical therapists (DPT), nurses (DPN) at the University of Colorado who will complete the Masters of Clinical Science degree and veterinarians completing a PhD from Colorado State University, our partnering university, that are team-oriented and have developed competencies necessary for successful translational science and research careers.

PI_NAMEs: CICUTTO, LISA  (contact)

PROGRAM_OFFICER_NAME: CONROY, JENNIE LYNN

PROJECT_TITLE: CTSA Postdoctoral T32 at University of Colorado Denver


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Climate-Related Exposures and Conditions;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Social Determinants of Health;Violence Against Women;Violence Research;Women's Health Research

ORG_CITY: MINNEAPOLIS

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: NARRATIVE Climatic and non-climatic extreme events, or shocks, are dramatically impacting human health. This research uses novel mobility data derived from mobile phones, georeferenced environmental and contextual data (e.g., weather extremes, natural disasters, and armed conflict), and population-representative health data to assess the impact of these shocks and shock-induced changes in mobility patterns on women’s risk of intimate partner violence in Kenya. This work will inform policy and interventions to prevent intimate partner violence and other health threats for women in the face of ongoing and increasing climate shocks and other extreme events.

PI_NAMEs: LUETKE, MAYA  (contact)

PROGRAM_OFFICER_NAME: CAPPS, RANDOLPH CHRISTOPHER

PROJECT_TERMS: Acceleration;Address;Adverse effects;Affect;Africa South of the Sahara;African;analytical method;artificial intelligence method;Award;Big Data;career;career development;career preparation;Categories;Cellular Phone;Climate;climate change;climate impact;climate variability;combat;Communities;Conflict (Psychology);Country;Coupled;Cross-Sectional Studies;Data;Data Sources;Demographic and Health Surveys;Disasters;Disease Outbreaks;Domestic Violence;Emergency response;Empirical Research;Environment;Epidemic;Event;experience;Exposure to;extreme weather;Face;Faculty;Food;Foundations;Frequencies;Future;Gender;gender equity;global health;Goals;Health;health data;health determinants;health disparity;health equity;health inequalities;Healthcare;Human;human migration;Individual;Inequity;innovation;Intervention;intimate partner violence;Kenya;Knowledge;Learning;Letters;Life;Link;Location;Machine Learning;machine learning algorithm;machine learning method;Maps;Measures;Mediating;Mediator;member;Mentors;Mentorship;Methodology;Methods;migration;Minnesota;Mission;Monitor;Morbidity - disease rate;mortality;multidisciplinary;National Institute of Child Health and Human Development;Natural Disasters;novel;Outcome;Pathway interactions;Patient Self-Report;Pattern;Performance;Personal Satisfaction;Persons;Phase;Policies;Population;population health;Positioning Attribute;Poverty;prevent;Process;programs;Rain;Recording of previous events;Research;Research Personnel;resilience;Resource-limited setting;Resources;response;Risk;Role;Services;Sex Discrimination;Shelter facility;Shock;skills;social;social disparities;social norm;Social Sciences;Social support;Solid;Source;spatial epidemiology;spatial integration;statistics;Surveys;System;Temperature;temporal measurement;tenure track;Testing;theories;Time;Training;trend;Violence;Volatilization;Water;Woman;Women's Health;women's outcomes;Work

PROJECT_TITLE: Novel use of mobile phone big data to evaluate the effect of climatic and non-climatic shocks on human mobility and women's health outcomes in sub-Saharan Africa

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Population Sciences Study Section[CHHD-W]


NIH_SPENDING_CATS: Cancer;Clinical Research;Dental, Oral, and Craniofacial Disease;Genetic Testing;Genetics;Neurosciences;Prevention;Rare Diseases

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE We have demonstrated that biofluids in close proximity to cancers are significantly enriched for levels of released tumor DNA, which permits for greater sensitivity and potentially specificity. In this proposal we will utilize a multi-analyte approach including mutations, aneuploidy, fragmentomics and methylation to develop liquid biopsy approaches for pre-neoplastic and neoplastic conditions involving the brain and head and neck by analyzing cerebrospinal fluid and saliva respectively. We will work closely with our industrial partners, Belay Diagnostics, to validate the performance of our assays and develop CLIA certified tests ready for clinical implementation.

PI_NAMEs: AGRAWAL, NISHANT ;BETTEGOWDA, CHETAN ;PAPADOPOULOS, NICKOLAS  (contact)

PROGRAM_OFFICER_NAME: HODGES, NICHOLAS AARON

PROJECT_TERMS: Achievement;Affect;Agreement;Aneuploidy;Area;Bioinformatics;Biological Assay;Biology;Blood;Brain;brain abnormalities;brain magnetic resonance imaging;burden of illness;cancer biomarkers;cancer cell;Cancer Detection;cancer diagnosis;cancer risk;cancer type;case control;Cerebrospinal Fluid;Cessation of life;Circulation;CLIA certified;Clinical;clinical application;clinical implementation;clinical translation;cohort;Coin;Collaborations;cost;Data;Detection;detection assay;Diagnosis;Diagnostic;DNA;Early Diagnosis;Epigenetic Process;experience;Funding;Genomic Library;Goals;Head and Neck Cancer;Head and neck structure;improved;Individual;Industrialization;Industry Collaboration;industry partner;Industry Standard;Intervention Trial;Libraries;liquid biopsy;Liquid substance;Logistic Regressions;machine learning algorithm;Malignant - descriptor;Malignant neoplasm of brain;Malignant Neoplasms;Medical;member;Methods;Methylation;minimally invasive;Modality;Modeling;Molecular;Morbidity - disease rate;mortality;Mutation;Neoplasms;neoplastic;novel;oral lesion;Organ;Outcome;Output;parent grant;Performance;Plasma;Procedures;Process;prospective;Protein Secretion;Protocols documentation;Quality Control;Saliva;sample collection;screening;Screening for cancer;Signal Transduction;Site;specific biomarkers;Specificity;standard of care;Target Populations;Technology;Testing;Translating;tumor;tumor DNA;Tumor-Derived;Validation;Woman;Work

PROJECT_TITLE: Multi-analyte Approach for Earlier Detection of Cancers in Non Plasma Biofluids


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: HOUSTON

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: PROJECT NARRATIVE Cytoplasmic compartmentalization mechanisms have the potential to influence broad cellular processes and pathways, including how, when, and where mRNAs are translated, silenced, or degraded. The research outlined in this proposal will elucidate the molecular and functional role of a new cytoplasmic niche between membrane- bound organelles and membrane-less RNA-protein organelles. We expect the results from these studies will yield fundamental insights into how cells under duress rapidly switch from bulk mRNA translation to sequestration, as well as, how cells prevent membrane-less organelles from developing into toxic RNA-protein aggregates.

PI_NAMEs: LEE, JASON EDWARD (contact)

PROGRAM_OFFICER_NAME: MACARTHUR, LINDA

PROJECT_TERMS: aqueous;Basic Science;Binding;Biochemical;Biophysics;Cell Physiology;Cells;Cytoplasm;Dependence;Disease;Endoplasmic Reticulum;Eukaryotic Cell;Goals;Health;imaging approach;In Vitro;in vivo;insight;Life Cycle Stages;Lipids;live cell imaging;Maintenance;Malignant Neoplasms;Mediating;Membrane;Messenger RNA;Molecular;Morphology;mRNA Translation;Nerve Degeneration;Organelles;Pathway interactions;Physical condensation;Play;prevent;Process;programs;protein aggregation;Proteins;Quality Control;Reaction;recruit;Research;RNA;RNA Processing;RNA Virus Infections;Role;Site;stress granule;Structure;Testing;Translating;translational medicine;vesicle transport;Work

PROJECT_TITLE: Factors and Functions of Contact Sites between Membrane-bound and Membrane-less Organelles

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CDB-B(55)R]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: PLAINFIELD

ORG_NAME: ALCORIX

ORG_STATE: IL

PHR: Project Narrative This project will advance basic neuroscience research tools by developing a novel implantable octrode probe, to be the first on the market for real-time, simultaneous direct measurement of the critical neurotransmitters, gamma-aminobutyric acid (GABA) and glutamate. The multiplexing and in vivo capabilities of the probe will allow researchers to develop more effective animal models and therapeutics for brain diseases and mental disorders, which affect millions of Americans such as Alzheimer’s Disease (15M), Epilepsy (4M), and Parkinson’s disease (1.5M), and costs over $1.5 trillion in healthcare spending annually.

PI_NAMEs: ARUMUGAM, PRABHU ;MOLDOVAN, NICOLAIE ANDREI (contact);VETTER, RIO J

PROGRAM_OFFICER_NAME: AUBRECHT, TARYN GRACE

PROJECT_TERMS: Acceleration;addiction;Affect;Alzheimer's Disease;American;Animal Model;Animals;Area;barrel cortex;Behavioral;Biological Markers;biomaterial compatibility;Biosensor;Brain;Brain Diseases;BRAIN initiative;Calibration;Chemicals;Chronic;Communication;Cortical Column;cost;Dementia;density;design;Detection;detection sensitivity;Development;Disease;disease model;Drug Delivery Systems;Drug usage;effective therapy;Electrodes;Electrophysiology (science);Enzymes;Epilepsy;Equilibrium;Event;Feasibility Studies;flexibility;Formulation;functional improvement;gamma-Aminobutyric Acid;Glutamates;Goals;Healthcare;Homeostasis;Human;Hybrids;Hydrogels;Implant;improved;In Situ;In Vitro;in vivo;in vivo evaluation;Inflammation;information processing;Lead;Louisiana;manufacture;Marketing;Measurement;Measures;Mechanics;Memory;Mental disorders;Methods;Microdialysis;Microelectrodes;Microfluidics;miniaturize;Modeling;Monitor;Motion;National Institute of Neurological Disorders and Stroke;Nervous System Disorder;neural;neural implant;neurochemistry;neuronal circuitry;Neuronal Plasticity;Neurons;Neurosciences;Neurosciences Research;Neurotoxins;neurotransmission;Neurotransmitters;novel;Parkinson Disease;Pattern;Penetration;Performance;Peroxides;Pharmaceutical Preparations;Phase;Physiological;Platinum;Play;Polymers;Process;process improvement;Property;prototype;Rattus;Reagent;Reproducibility;Research;Research Personnel;Resistance;Resolution;response;Role;Schizophrenia;sensor;Silicon;Small Business Technology Transfer Research;somatosensory;spatiotemporal;Techniques;Technology;Temporal Lobe Epilepsy;temporal measurement;Testing;Therapeutic;Time;tool;Universities;usability;Validation;Vibrissae;Work

PROJECT_TITLE: Implantable Microarray Probe for Real-Time Glutamate and GABA Detection

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-NV-C(10)B]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Genetics;Human Genome;Pediatric;Rare Diseases

ORG_DEPT: DENTISTRY

PHR: PROJECT NARRATIVE The human facial skeleton originates from groups of cells in specific positions with unique identities, each instructing the formation of a different skeletal structure. We hypothesize that in human genetic diseases, like frontonasal dysplasia, the ability to establish these identities is disrupted. In this proposal we use zebrafish disease models to investigate a hypothetical identity ‘code’ instructing positional cellular identity, thus informing the etiology of these devastating birth defects.

PI_NAMEs: NICHOLS, JAMES TUCKER (contact)

PROGRAM_OFFICER_NAME: SAIFUDEEN, ZUBAIDA

PROJECT_TERMS: 3-Dimensional;Affect;Antibodies;Binding;Binding Sites;Bone structure;cartilaginous;Cell Differentiation process;Cells;ChIP-seq;chromatin immunoprecipitation;Code;Color;Congenital Abnormality;craniofacial;craniofacial development;Data;Development;disease model;domain mapping;Dysmorphology;Elements;Embryonic Development;Enhancers;Etiology;experimental study;Eye;Face;Frontonasal dysplasia;Gene Combinations;Gene Expression;gene function;Genes;Genetic;Genetic Diseases;Genetic Transcription;Genome;Genomics;Head;Health;Hi-C;Human;human disease;Human Genetics;improved;In Situ Hybridization;in vivo;innovation;Jaw;Maps;Mediating;Methods;Mission;Modeling;Molecular;mutant;Mutation;National Institute of Dental and Craniofacial Research;Neural Crest Cell;Nose;Orthologous Gene;paralogous gene;Pattern;Phenotype;Positioning Attribute;progenitor;promoter;Proteins;Publishing;Reporter;Research;Resolution;Shapes;single-cell RNA sequencing;skeletal;Skeleton;Specific qualifier value;Structure;success;System;Testing;Time;transcription factor;Transgenes;vertebrate genome;Work;Zebrafish;zebrafish development

PROJECT_TITLE: Mechanisms patterning the midface

STUDY_SECTION: SBDD

STUDY_SECTION_NAME: Skeletal Biology Development and Disease Study Section[SBDD]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Pediatric;Social Determinants of Health;Substance Misuse;Underage Drinking

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: Project Narrative We propose to apply a novel method of modeling dual trajectories of alcohol use and binge drinking in a longitudinal cohort from age 15 to 40. Using the social-ecological framework, we will then investigate the role of familial and environmental factors in adolescence on alcohol use trajectories. A better understanding of alcohol use patterns across the life course and key influences during adolescence may help inform harm reduction interventions.

PI_NAMEs: RANKER, LYNSIE  (contact)

PROGRAM_OFFICER_NAME: CASTLE, I-JEN

PROJECT_TERMS: Adolescence;Adolescent;Adult;Adverse event;Age;age group;aged;alcohol behavior;Alcohol consumption;alcohol related problem;alcohol research;alcohol risk;alcohol use disorder;alcohol use initiation;Alcohols;Behavior;Behavioral;behavioral outcome;Belief;binge drinking;Child;Child Rearing;cohort;community-level factor;Consumption;contextual factors;critical developmental period;Data;Development;drinking;drinking behavior;drinking onset;early drinking;emerging adult;Emotional;Environment;Environmental Risk Factor;Event;experience;Family;follow-up;Frequencies;Future;Goals;Growth;Harm Reduction;high risk;Individual;interest;Intervention;Interview;Life Cycle Stages;Literature;Longitudinal cohort;Masks;Mental Health;Methods;Modeling;National Institute on Alcohol Abuse and Alcoholism;National Longitudinal Survey of Youth;novel;Odds Ratio;Outcome;Pattern;Persons;Policies;Political Factor;prevent;Process;Public Health;public policy on alcohol;Research;Role;Sampling;secondary analysis;social;Societal Factors;Subgroup;substance use;Time;traumatic event;Variant;Work;young adult;Youth

PROJECT_TITLE: Familial and Environmental Determinants of Alcohol Use Trajectories: Examining 25 Years of Follow-up Data in a Nationally Representative Cohort of Youth

STUDY_SECTION: SSPB

STUDY_SECTION_NAME: Social Sciences and Population Studies B Study Section[SSPB]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Genetics;Infectious Diseases;Mental Health;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention

ORG_CITY: DAVIS

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Despite strong links between maternal infections experienced during pregnancy and risk for offspring neurodevelopmental disorders, little is known about the underlying neurobiological mechanisms that lead to alterations in the trajectory of brain development. The proposed studies will utilize a translationally relevant preclinical model to evaluate cellular and molecular mechanisms underlying aberrant neurodevelopment. If successful, our results will identify causal pathways in specific neural circuits vulnerable to prenatal immune challenge, which is an essential next step in efforts to develop novel therapeutic interventions and preventative strategies.

PI_NAMEs: BAUMAN, MELISSA DAWN;SCHUMANN, CYNTHIA  (contact)

PROGRAM_OFFICER_NAME: TONELLI, LEONARDO HERALDO

PROJECT_TERMS: Adolescent;Affect;Age;Amygdaloid structure;Anatomy;Anterior;Array tomography;autism spectrum disorder;Bacterial Infections;Behavioral;biobank;Biological Markers;Biological Response Modifier Therapy;Birth;Brain;brain circuitry;Brain region;brain tissue;Cell Nucleus;cell type;Cells;Child;Cognition;cohort;Complex;critical period;Data;density;Development;differential expression;Disease;Emotional;emotional behavior;Environment;Equilibrium;Event;Exhibits;experience;Exposure to;Female;fetal;Fluorescent in Situ Hybridization;Functional disorder;Gene Expression Profile;Genes;glutamatergic signaling;Glutamates;Goals;Human;Human Development;Immune;immune activation;Immune response;Individual;Infection;Intervention;Knowledge;Label;Laboratories;Lateral;Link;male;Maps;Maternal-Fetal Exchange;Mediating;Mental disorders;Mental Health;Modeling;Molecular;neural circuit;Neuroanatomy;neurobiological mechanism;Neurobiology;neurodevelopment;Neurodevelopmental Disorder;Neuropil;neurotransmission;nonhuman primate;novel;novel therapeutic intervention;offspring;Pathway interactions;Physiology;Placenta;Population;postnatal;postsynaptic;pre-clinical;Pre-Clinical Model;Prefrontal Cortex;Pregnancy;prenatal;prenatal exposure;presynaptic;Prevention strategy;Primates;programs;Proteins;receptor;Research;response;Risk;Risk Factors;Rodent Model;Schizophrenia;segregation;Signal Pathway;single molecule;single nucleus RNA-sequencing;Social Behavior;social cognition;Spatial Distribution;Structure;Synapses;Synaptic Transmission;Testing;Time;timeline;Tissue Banks;tissue resource;Tissues;Transcript;transcriptomics;Translating;ultra high resolution;Viral;Virus Diseases

PROJECT_TITLE: Alterations in primate brain development following prenatal immune challenge

STUDY_SECTION: PMDA

STUDY_SECTION_NAME: Pathophysiological Basis of Mental Disorders and Addictions Study Section[PMDA]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences;Substance Misuse

ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

PHR: Project Narrative This proposal will advance the understanding of how chronic alcohol intake promotes behavioral engagement for alcohol through cortical-noradrenaline signaling. These results have the potential to provide new therapeutic strategies for treating individuals at risk of developing or that have alcohol use disorder.

PI_NAMEs: STARSKI, PHILLIP A (contact)

PROGRAM_OFFICER_NAME: LIU, QI-YING

PROJECT_TERMS: Address;Advisory Committees;Alcohol abuse;alcohol behavior;Alcohol consumption;alcohol exposure;alcohol research;alcohol reward;alcohol risk;alcohol seeking behavior;alcohol use disorder;Alcohols;Anatomy;Animals;Anterior;Attention;Attenuated;awake;Award;Awareness;Behavior;Behavior assessment;Behavioral;Behavioral Paradigm;Brain;career;career development;Chronic;cingulate cortex;Clinical;Collaborations;Communities;Consumption;Data Set;Dedications;density;design;Disease;drinking;Electrophysiology (science);endophenotype;Ensure;Environment;experimental study;Faculty;Foundations;Future;Genetic;genetic manipulation;Genetic Predisposition to Disease;Goals;Habits;Impairment;Implant;Impulsivity;in vivo;Indiana;Individual;Individual Differences;Institution;Insula of Reil;Intake;interest;Interoception;Journals;Learning;Link;locus ceruleus structure;male;Measures;Mediating;Mentors;Methods;Milk;Modeling;Molds;Motivation;Mus;neural;neural circuit;neuroadaptation;neuromechanism;Neurons;Neurosciences;noradrenergic;Norepinephrine;novel therapeutic intervention;Oral;Pathologic;Pattern;Performance;Phase;Phenotype;Play;Populations at Risk;Positioning Attribute;posters;preference;premature;Preparation;Principal Component Analysis;Publishing;Reaction Time;reinforcer;Research;Research Personnel;Resources;response;Rewards;Risk;Rodent;Role;Signal Transduction;Silicon;success;sugar;Supervision;symposium;System;Techniques;Testing;Therapeutic;therapeutic target;Training;trait impulsivity;Universities;vigilance;Water;Work

PROJECT_TITLE: Cortical-noradrenaline signaling in alcohol behavioral engagement


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Batten Disease;Biotechnology;Brain Disorders;Dementia;Gene Therapy;Genetics;Neurodegenerative;Neurosciences;Orphan Drug;Pediatric;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE In two-thirds of lysosomal storage disorders (LSD), patients suffer neurologic symptoms that are not corrected by most therapies, including gene replacement, especially if treatment is given after symptom onset. We recently identified pathologic changes in hippocampal network dynamics that arise early in CLN3 disease, a representative LSD, and the most common cause of pediatric dementia. The goal of this project is to understand if early, progressive changes in network physiology in CLN3 disease will establish a point beyond which gene therapy cannot restore function to a diseased neuronal circuit and to explore if modulating network activity can modify the efficacy of gene replacement.

PI_NAMEs: AHRENS-NICKLAS, REBECCA CLARE (contact)

PROGRAM_OFFICER_NAME: MORRIS, JILL A

PROJECT_TERMS: Address;Adolescent;Affect;Age;Alzheimer's Disease;Alzheimer's disease model;behavioral phenotyping;Blindness;Brain;Central Nervous System;Cerebrum;Cessation of life;Child;Childhood;Chronic;Clinical;clinical practice;Clinical Trials;CLN3 gene;Compensation;Data;Deep Brain Stimulation;Defect;Degenerative Disorder;Dementia;dentate gyrus;designer receptors exclusively activated by designer drugs;Development;Diagnosis;Disease;disease model;Dose;Electroencephalography;Electrophysiology (science);entorhinal cortex;enzyme replacement therapy;Fimbria of hippocampus;Functional disorder;functional restoration;Gene Expression;gene replacement;gene therapy;gene-targeted therapy;Genetic;Glutamates;Goals;Hippocampus;Histology;Histopathology;Housing;Human;Image;improved;improved outcome;in utero;In Vitro;in vivo;Individual;Knock-out;Knockout Mice;Measures;Memory;Methods;Modeling;mouse model;Mus;Mutation;Nerve Degeneration;neurodevelopment;neurogenesis;Neurologic Deficit;Neurologic Symptoms;Neuronal Ceroid-Lipofuscinosis;neuronal circuitry;Neurons;novel strategies;Organoids;Outcome;Pathologic;Pathology;Patients;Phenotype;Physiological;Physiology;Process;Progressive Disease;protein expression;Reporting;Reproducibility;response;Rett Syndrome;Seizures;Symptoms;Testing;Therapeutic;therapy development;Time;Treatment Efficacy;Variant;Viral;voltage sensitive dye;Work

PROJECT_TITLE: Network modulation to improve gene therapy in CLN3 disease

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurosciences;Rehabilitation;Social Determinants of Health;Substance Misuse

ORG_CITY: WALTHAM

ORG_DEPT: MISCELLANEOUS

ORG_NAME: BRANDEIS UNIVERSITY

PHR: Narrative To improve health outcomes for people with disabilities, an overlooked health disparities population, this proposed study will use complementary datasets from the National Survey on Drug Use and Health, and commercial (MarketScan) and public (Medicaid) health care claims, to investigate differences in alcohol use, alcohol-related morbidity, and alcohol use disorder by disability status. Uniquely, this study will determine if disparities exist for people with disabilities regarding access, quality, and outcomes of treatment for alcohol use disorder. Knowledge gained will inform improvements in the health and wellbeing for people with disabilities by identifying where policy and practice changes are most needed to reduce future alcohol-related morbidity and consequences.

PI_NAMEs: ADAMS, RACHEL SAYKO;REIF, SHARON  (contact)

PROGRAM_OFFICER_NAME: WHITAKER, DAMIYA EVE

PROJECT_TERMS: ableism;Acceleration;access disparities;Acute;addiction;Address;Adult;Affect;alcohol abstinence;Alcohol abuse;alcohol abuse therapy;alcohol availability;alcohol consequences;Alcohol consumption;Alcohol dependence;alcohol risk;alcohol screening;alcohol services;alcohol use disorder;Alcohols;Americans with Disabilities Act;barrier to care;blind;Brain Injuries;Caring;Cognition;Communities;comorbidity;cost;Data;Data Set;Data Sources;deaf;Diagnosis;disability;Disability disparity;Disability outcome;Disability status;Disabled Persons;Disabling condition;Discrimination;Disparity;Drug usage;experience;Foundations;Future;hard of hearing;Health;health care disparity;health care quality;health care settings;health data;health definition;health disparity;health disparity populations;health inequalities;Health Services Accessibility;Healthcare;Hearing;high risk;high risk drinking;Household;improved;Independent Living;Institute of Medicine (U.S.);Insurance;Intellectual functioning disability;interest;intersectionality;Knowledge;Literature;low socioeconomic status;Measures;Medicaid;Medical;men;Mental Health;Methodology;Methods;Mobility decline;Morbidity - disease rate;opioid use disorder;Outcome;Pain;Patient Self-Report;Pattern;Personal Satisfaction;Persons;Pharmaceutical Preparations;physical conditioning;Policies;Policy Maker;Population;Quasi-experiment;Recording of previous events;Research;Research Personnel;Risk;Risk Factors;Sampling;Self Care;severe mental illness;social health determinants;Social isolation;social stigma;Socioeconomic Status;Spinal cord injury;Stigmatization;Surveys;theories;Transportation;Trauma;Traumatic Brain Injury;treatment comparison;Treatment outcome;treatment services;Update;Vision;Visual impairment;women with disabilities;women's outcomes;Work

PROJECT_TITLE: INROADS-A: Intersecting Research on Addiction and Disability Services - Alcohol

STUDY_SECTION: AA

STUDY_SECTION_NAME: Clinical, Treatment and Health Services Research Study Section[AA-3]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

PHR: Narrative Clonal hematopoiesis is the phenomenon of age-related outgrowth of somatic clones in the blood. It can be detected from the discovery of somatic CNVs in blood samples. We will discover and analyze somatic CNVs in the blood of individuals enrolled in the All of Us initiative. Completing this project will result in a resource of somatic CNVs that can be leveraged by various studies utilizing data in the All of Us project. Results will also provide a new insight into the etiology of somatic CNVs in the blood. 2

PI_NAMEs: ABYZOV, ALEXEJ  (contact)

PROGRAM_OFFICER_NAME: GUO, MAX

PROJECT_TERMS: Age;age related;Alzheimer's disease risk;autism spectrum disorder;Blood;Blood specimen;Brain;Cardiovascular Diseases;Cell division;Cells;cohort;Collection;Copy Number Polymorphism;Data;Detection;Development;Disease;Documentation;driver mutation;Enrollment;Etiology;Frequencies;Future;Genes;genetic variant;Genome;genome sequencing;Genomics;Germ Lines;Gilles de la Tourette syndrome;Hematopoiesis;Hematopoietic;Hematopoietic Neoplasms;Individual;Inherited;insight;Length;Manuals;Methodology;Methods;mortality;Mosaicism;Mutagenesis;Mutation;neuropsychiatric disorder;Outcome;Phenotype;Point Mutation;Predisposition;Process;Research;Research Personnel;Resources;Risk;Role;sample collection;Schizophrenia;sex;Signal Transduction;SNP array;Somatic Cell;Somatic Mutation;Stratification;Testing;tool;transmission process;Variant;Visualization;whole genome;Work;Y Chromosome

PROJECT_TITLE: Discovering and Analyzing Development and Age-Associated CNAs in the All of Us Cohort


ORG_NAME: TREVARX BIOMEDICAL, INC.

PHR: NARRATIVE: To develop and commercialize [18F]fluorthanatrace ([18F]FTT), a PET tracer that measures PARP-1 expression and PARP inhibitor target engagement, Trevarx Biomedical Inc. and the University of Pennsylvania are proposing a Phase II STTR project to develop an efficient method for synthesizing [18F]FTT for widespread distribution, one that maximizes product consistency and production yield. The proposed project will result in a standardized procedure that will support larger multi-center trials that can be easily adapted by commercial radiopharmacies to provide a widescale supply of [18F]FTT following FDA approval, thereby providing a valuable imaging biomarker that will enable better guidance of PARPi treatment for many cancer patients. This project is innovative since it will establish a new roadmap for the rapid commercialization of PET radiopharmaceuticals to efficiently bring novel PET tracers to market.

PI_NAMEs: LEE, HSIAOJU SHARON;MIKHAIL, MICHEL  (contact)

PROGRAM_OFFICER_NAME: ZHAO, MING

PROJECT_TERMS: analog;Binding;Biological Assay;Breast;Cancer Patient;clinical center;clinical translation;Clinical Trials;commercialization;companion animal;companion diagnostics;Cyclic GMP;Databases;design;Development;Drug Formulations;Drug Stability;efficacy trial;Ensure;Formulation;Foundations;Gene Mutation;Genes;Genomics;Image;imaging biomarker;improved;in vivo;Industry;innovation;Label;Lead;Malignant Breast Neoplasm;Malignant neoplasm of ovary;Malignant Neoplasms;Marketing;Measures;Methods;Modeling;Monitor;Multi-Institutional Clinical Trial;Multicenter Trials;novel;Ovarian;Patient imaging;Pennsylvania;Performance;performance site;Pharmaceutical Preparations;Phase;phase 2 study;phase II trial;Phase III Clinical Trials;phase III trial;Poly(ADP-ribose) Polymerase Inhibitor;Positron-Emission Tomography;pre-Investigational New Drug meeting;precision oncology;predictive marker;Preparation;Procedures;Process;Production;Prostate;protein expression;Proteins;quantitative imaging;Radiolabeled;Radiopharmaceuticals;radiotracer;Reagent;Recommendation;repaired;response;Sampling;Site;Small Business Technology Transfer Research;Specific qualifier value;Standardization;success;supply chain;targeted treatment;Technology Transfer;Testing;timeline;Tissues;Tracer;Translating;tumor;Universities;uptake;Writing

PROJECT_TITLE: Optimizing Radiosynthetic Yield of [18F]FTT For Wide-Spread Distribution

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ISB-Z(10)B]


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Congenital Muscular Dystrophy;Congenital Structural Anomalies;Intellectual and Developmental Disabilities (IDD);Muscular Dystrophy;Neurosciences;Orphan Drug;Pediatric;Rare Diseases

ORG_CITY: COLUMBUS

ORG_NAME: RESEARCH INST NATIONWIDE CHILDREN'S HOSP

PHR: This collaboration addresses a major gap in trial readiness for children with LAMA2 related dystrophies (LAMA2-RD) for whom therapeutic trials are rapidly emerging, through validation of clinical outcome assessments and biomarkers in infants and children five years of age or younger. The deidentified data from this study will be available for any investigator or company pursuing treatments for children with LAMA2-RD.

PI_NAMEs: CONNOLLY, ANNE M (contact)

PROGRAM_OFFICER_NAME: GARCIA, LINA FERNANDA

PROJECT_TERMS: 5 year old;Address;Advocacy;Affect;Age;age group;biceps brachii muscle;Biological Markers;biomarker validation;Birth;Blinded;Breathing;Capnography;Carbon Dioxide;Caregivers;Certification;Characteristics;Chest;Child;Child Development;Childhood;Clinical;clinical outcome assessment;clinical research site;clinical trial readiness;Clinical Trials;Clinical Trials Design;Clustered Regularly Interspaced Short Palindromic Repeats;cognitive development;cohort;Collaborations;congenital muscular dystrophy;Contracture;COVID-19 pandemic;Creatine Kinase;Data;data de-identification;Deglutition;design;Development;Diameter;Disability Evaluation;Disease Progression;drug development;Duchenne muscular dystrophy;efficacy evaluation;Eligibility Determination;Enrollment;Equipment and supply inventories;Evaluation;Exclusion Criteria;Exhalation;feeding;Future;Gene Transfer;Genes;Geography;Goals;impression;improved;inclusion criteria;infancy;Infant;Inherited;Inhibition of Apoptosis;intervention effect;Joints;laminin alpha 2;Language;Language Development;Life;Location;Measures;Medical;Methods;Modeling;Motor;mouse model;Multicenter Studies;Muscle;Muscle hypotonia;Muscle Weakness;Muscular Atrophy;Muscular Dystrophies;Mutation;neuromuscular;Neuromuscular conditions;Neuromuscular Diseases;novel;novel marker;Outcome;Outcome Assessment;Outcome Measure;Parents;Participant;Pathogenesis;Pediatric Hospitals;Persons;Phase;Philadelphia;pre-clinical;preclinical development;progression marker;prospective;Proteins;Quality of life;Rare Diseases;rate of change;recruit;rectus femoris;remote assessment;Research Personnel;Respiratory Insufficiency;Respiratory physiology;response;Risk;scoliosis;Secondary to;Seizures;Serum;Severities;Site;Social Development;Testing;Therapeutic;Therapeutic Intervention;Therapeutic Trials;Time;Toddler;Training;Translating;Travel;treatment strategy;trial design;trial readiness;ultrasound;United States National Institutes of Health;Universities;Up-Regulation;Validation;Visit;Walking;Washington;World Health Organization

PROJECT_TITLE: Clinical Trial Readiness for Children 0-5 years with Congenital Muscular Dystrophy Secondary to LAMA2 Mutations


NIH_SPENDING_CATS: Autoimmune Disease;Cancer;Cancer Genomics;Clinical Research;Diabetes;Genetics;Human Genome;Immunotherapy

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative: Therapeutic agents targeting checkpoint inhibitors have transformed cancer treatment by enhancing anti-tumor immune responses but can also cause a breakdown in self-tolerance resulting in autoimmune complications affecting most organs. We showed that changes in immune cells and their inflammatory mediators modify pancreatic β cells and cause diabetes following checkpoint inhibitor immunotherapy. The proposed studies, using checkpoint inhibitor-induced diabetes as a model, will enhance our understanding of immune-target cell interactions and the impact of tumor on development of immune related adverse events, which could potentially lead to identification of biomarkers and therapeutic targets of these events that do not impact tumor responses.

PI_NAMEs: PERDIGOTO, ANA LUISA JORDAO (contact)

PROGRAM_OFFICER_NAME: LIM, SUSAN E

PROJECT_TERMS: Address;Adrenal Glands;Adverse event;Advisory Committees;Affect;anti-PD-L1;anti-PD-L1 therapy;anti-tumor immune response;Antigens;Area;authority;Autoantigens;Autoimmune;Autoimmunity;Beta Cell;Bioinformatics;biomarker discovery;biomarker identification;Body System;Cancer Patient;cancer therapy;career development;Cell Communication;Cells;Clinical;Coculture Techniques;Collaborations;collaborative environment;Complication;CTLA4 gene;Development;Development Plans;Diabetes Mellitus;diabetic;diagnostic development;Endocrine;Endocrine Glands;Endocrinologist;Endocrinology;Environment;Event;Exocrine pancreas;experience;Extramural Activities;Fatality rate;Fellowship;Gene Expression;Genetic Transcription;genomic data;Goals;Grant;Human;Immune;immune cell infiltrate;Immune checkpoint inhibitor;Immune response;Immune Targeting;Immune Tolerance;immune-related adverse events;Immunohistochemistry;Immunologist;Immunology;Immunooncology;Immunotherapy;improved;In Vitro;Inbred NOD Mice;Inflammation Mediators;Insulin-Dependent Diabetes Mellitus;islet;Islet Cell;Islets of Langerhans;Kinetics;Knowledge;Lead;Ligands;Malignant Neoplasms;medical schools;Mentorship;Modeling;Monoclonal Antibodies;Morbidity - disease rate;mortality;mouse genetics;mouse model;Mus;Nature;neoplastic cell;Non obese;novel;Organ;Pancreas;Pathogenesis;Patients;Phenotype;Physicians;Pituitary Gland;post-doctoral training;prevent;Principal Investigator;Productivity;programmed cell death ligand 1;programmed cell death protein 1;Reaction;receptor;Research;Research Personnel;Resources;response;Role;Scientist;Self Tolerance;single-cell RNA sequencing;skills;Stains;Structure of beta Cell of islet;T cell clonality;T cell receptor repertoire sequencing;T cell response;T-Cell Receptor;T-Lymphocyte;targeted treatment;Testing;Therapeutic;therapeutic target;therapy development;Thyroid Gland;Time;Tissues;tool;Training;translational study;tumor;tumor growth;tumor progression;Universities;validation studies;Work

PROJECT_TITLE: Elucidating mechanisms of checkpoint inhibitor-induced diabetes

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


NIH_SPENDING_CATS: Aging;Alcoholism, Alcohol Use and Health;Digestive Diseases;Genetics;Hematology;Human Genome;Liver Disease;Prevention;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Substance Misuse;Transplantation

PHR: Project Narrative Alcohol drinking can cause DNA damage, which is playing a key role in aging. Older individuals are more vulnerable to alcohol’s harmful effects and may suffer from accelerated aging due to alcohol-induced DNA damage. Our study will help us to better understand key aspects of aging caused by low-to-moderate alcohol drinking.

PI_NAMEs: JUNG, MOONJUNG  (contact)

PROGRAM_OFFICER_NAME: GAO, PETER

PROJECT_TERMS: 8-hydroxy-2'-deoxyguanosine;Acetaldehyde;Address;age acceleration;age related;aged;Aging;aging population;aging process;aging related;alcohol abuse therapy;Alcohol consumption;alcohol effect;alcohol exposure;alcohol prevention;alcohol research;alcohol risk;alcohol sensitivity;Alcohol-Induced Disorders;Alcoholic Hepatitis;Alcohols;Anemia;Animal Model;Base Excision Repairs;Bone Marrow;Bone marrow failure;Bone Marrow Suppression;Bone Marrow Transplantation;Brain;Cell Aging;Cell Line;Cells;Chronic;chronic alcohol ingestion;CRISPR screen;Data;deregulated nutrient-sensing;dietary supplements;DNA Damage;DNA lesion;DNA Repair;DNA Repair Gene;DNA Repair Pathway;Dose;drinking;Dysmyelopoietic Syndromes;Epigenetic Process;Fanconi's Anemia;feeding;folic acid metabolism;Funding;Future;Gamma-H2AX;General Population;Genes;Genetic;genetic variant;Genome;genome integrity;Genomics;Germ-Line Mutation;Goals;Health;Heavy Drinking;Hematologic Neoplasms;Hematopoiesis;Hematopoietic;hematopoietic stem cell aging;Hematopoietic stem cells;Human;Human Cell Line;In Vitro;Individual;Inflammation;insight;Iron;Japanese;Jurkat Cells;Knowledge;Lesion;Leukopenia;Light;Literature;Liver;Liver diseases;liver transplantation;Metabolic;Mitochondria;Mitochondrial DNA;Modeling;mouse model;Mus;Mutate;Myelogenous;National Institute on Alcohol Abuse and Alcoholism;new therapeutic target;Older Population;Organ;oxidative DNA damage;Pancytopenia;Pathway interactions;Patients;Physicians;Play;Population;Populations at Risk;Premature aging syndrome;Prevalence;prevent;Prevention;Principal Investigator;problem drinker;rate of aging;Rattus;Reactive Oxygen Species;repair function;repaired;Research;Research Personnel;response;Reticulocyte count;Risk;Rodent Model;Scientist;single-cell RNA sequencing;Source;stem cell exhaustion;stem cell population;Testing;therapeutic target;Thrombocytopenia;transplant model;Up-Regulation;Variant;Work

PROJECT_TITLE: Understanding the aging process in hematopoietic stem cells by alcohol-induced DNA damage

STUDY_SECTION_NAME: Biomedical Research Study Section[AA-1]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Pediatric;Prevention;Social Determinants of Health;Substance Misuse

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE We proposed to develop brief, accurate, survey-based screening tools for identifying substance-naïve youth at prospective risk of early, high-risk drinking and drug use during adolescence. By creating low-burden and generalizable measures for use in real-world settings, we will enable a more precise targeting of preventive interventions and clinical services toward the youth at greatest risk of negative long-term outcomes (e.g., chronic substance use disorder), thereby improving public health outcomes.

PI_NAMEs: PELHAM III, WILLIAM ELLERBE (contact)

PROGRAM_OFFICER_NAME: CREAMER, MELISA RAY

PROJECT_TERMS: 10 year old;14 year old;Acceleration;Acute;Adolescence;Adolescent;adolescent substance use;Adult;Age;Alcohol abuse;Algorithm Design;Algorithms;Brain;Censuses;Child;Chronic;Cities;Clinical effectiveness;Clinical Services;Cognitive;cohort;Communities;cost effective;cost effectiveness;Cost Savings;Data;Data Set;Development;Drug abuse;Drug usage;Ensure;Equity;ethnic identity;Exhibits;Family;Gender Identity;health inequalities;Health Promotion;high risk;high risk drinking;improved;Individual;Inequity;Injury;instrument;Intervention;Investments;Link;Measures;Methodology;Methods;National Institute of Drug Abuse;novel;Outcome;Outcome Assessment;Pattern;peer;Performance;Population Heterogeneity;prevent;Prevention;Prevention program;Preventive;preventive intervention;Preventive service;Procedures;programs;prospective;Psychometrics;Public Health;racial identity;Research;resilience factor;Resources;Risk;Risk Estimate;Risk Factors;Sampling;Schools;screening;Screening procedure;Services;sexual identity;simulation;Site;sociodemographics;Specific qualifier value;Stigmatization;Stretching;substance use;Substance Use Disorder;success;Surveys;Techniques;Testing;tool;Trust;uptake;Validation;Victimization;Work;Youth

PROJECT_TITLE: Development of practical screening tools to support targeted prevention of early, high-risk drinking substance use


ADMINISTERING_IC: HG

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

ORG_CITY: EDINBURG

ORG_NAME: UNIVERSITY OF TEXAS RIO GRANDE VALLEY

PHR: PROJECT NARRATIVE The University of Texas Rio Grande Valley seeks to establish a Diversity Center for Genome Research that will build genomics research capacity by 1) expanding genomic research capabilities and discoveries in two innovative research projects; and 2) enhancing the size and quality of the available genomics workforce. The Center will leverage the exciting activities and resources available in two highly innovative research projects, one focused on non-alcoholic fatty liver disease and one focused on major depressive disorder. The Center’s structure and approach are designed to expand the pool of diverse genomic scientists, clinician scientists, and researchers at both the doctoral and technical staff levels who can perform cutting-edge multidisciplinary genomics research.

PI_NAMEs: WILLIAMS-BLANGERO, SARAH A. (contact)

PROGRAM_OFFICER_NAME: RIVERS, ROBERT C

PROJECT_TERMS: Address;Anthropology;Area;Bioinformatics;career;career development;Collaborations;Communities;community center;community engagement;community organizations;Community Outreach;design;Development;Disease;disease disparity;Education;Education and Outreach;environmental chemistry;Environmental Epidemiology;Environmental Exposure;Equipment;experience;Extramural Activities;Faculty;Family;Fostering;Funding;Future;Genetic;genetic epidemiology;Genome;Genomics;Goals;Growth;Health;health disparity;higher education;Hispanic;hispanic community;Hispanic-serving Institution;Human Genetics;Image;improved;innovation;Institution;instrumentation;Interdisciplinary Study;interest;Investigation;Investments;literacy;Major Depressive Disorder;Medical;medical schools;Mexican;Mexican Americans;minority student;Molecular Genetics;multidisciplinary;Neurosciences;non-alcoholic fatty liver disease;novel;Population;Postdoctoral Fellow;Program Development;Program Sustainability;programs;Proteomics;recruit;Research;Research Personnel;Research Project Grants;Research Support;Resources;Science;Scientist;senior faculty;Services;skills;Statistical Methods;stem cell biology;Strategic Planning;Structure;Students;Techniques;Technology;Texas;Training;training opportunity;United States National Institutes of Health;Universities;university student;Workforce Development

PROJECT_TITLE: UTRGV Diversity Center for Genome Research


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome

PROJECT_TERMS: Administrator;Advisory Committees;Biomedical Research;Collaborations;Communication;Communities;Complement;Data;design;Ensure;Environment;Evaluation;experience;Extramural Activities;Fostering;Funding;Genes;Genetic;Genome;genome sciences;Genomics;Goals;Health;health disparity;Human;Human Genetics;human genomics;improved;Infrastructure;Institution;Institutionalization;Laboratories;Leadership;Measures;meetings;member;Mexico;Monitor;National Human Genome Research Institute;Newsletter;Non-Insulin-Dependent Diabetes Mellitus;Occupational activity of managing finances;organizational structure;outreach;Peer Review;Policies;Population;Process Assessment;Productivity;Program Sustainability;programs;Publications;Recommendation;Recording of previous events;Research;Research Infrastructure;Research Personnel;Research Project Grants;Research Support;Resources;Sampling;satisfaction;Scientist;Services;Site;South Texas;Structure;success;symposium;synergism;Texas;Trans-Omics for Precision Medicine;United States National Institutes of Health;Universities;user-friendly;web site;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Genetics;Human Genome

PROJECT_TERMS: Address;Area;Bioinformatics;Biology;Biomedical Research;Budgets;career;career awareness;Career Choice;career development;Career Mobility;Chemistry;college;Complex;computer science;Disease;doctoral student;Education;Educational Status;Educational workshop;Engineering;Enrollment;Environment;Environmental Risk Factor;Equipment;experience;Faculty;Familiarity;fatty liver disease;flexibility;Fostering;Funding;General Population;Genetic;genetic epidemiology;Genetic Research;Genome;genome sciences;Genomic approach;genomic tools;Genomics;Genotype;graduate student;Grant;Growth;health disparity;Health Personnel;Hispanic Populations;Human Genetics;human genomics;improved;Individual;induced pluripotent stem cell;innovation;Institution;interest;investigator training;Journals;K-12 Faculty;Knowledge;Learning;literacy;Major Depressive Disorder;Manuscripts;Medical Genetics;meetings;Mentors;Mexican Americans;minority scientist;minority trainee;multiple omics;novel;Patients;Persons;Postdoctoral Fellow;precision medicine;Preparation;programs;Proteomics;Publishing;Research;Research Design;Research Personnel;Research Project Grants;Risk;school district;Science;science education;Scientist;Series;skills;Students;success;symposium;synergism;System;Talents;teacher;tool;Training;training opportunity;transcriptomics;Underrepresented Populations;United States National Institutes of Health;Universities;web site;Work;Workforce Development;Writing

PROJECT_TITLE: Workforce Development Core


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Substance Misuse;Substance Misuse Prevention;Underage Drinking

ORG_CITY: RIVERSIDE

ORG_NAME: UNIVERSITY OF CALIFORNIA RIVERSIDE

PHR: PROJECT NARRATIVE  Native Hawaiian/Pacific Islander (NPI) young adults endure heavy alcohol-related disparities including high rates of hazardous drinking and alcohol use disorders that cause 40% of NPI young adults to suffer alcohol- related harms. Building on our intervention model of evidence-based alcohol prevention strategies selected and shaped in a prior NIAAA R21, this resubmitted R01 study will refine and then randomized controlled test SPEAR: a culturally grounded alcohol use disorder prevention intervention for NPI young adults. Using innovative community engaged research methods, this project will produce a first-of-its-kind culturally and community informed intervention to reduce alcohol use and prevent alcohol use disorders and harms in NPI young adults.

PI_NAMEs: SUBICA, ANDREW MAKOTO (contact)

PROGRAM_OFFICER_NAME: RUFFIN, BEVERLY

PROJECT_TERMS: active control;Adoption;Affect;Alcohol abuse;Alcohol consumption;alcohol prevention;alcohol related problem;alcohol research;alcohol use disorder;Alcohols;Arkansas;Asian Americans;Attention;binge drinking;Communities;community engaged intervention;community engaged research;community intervention;community research;Consensus;Country;County;culturally appropriate intervention;Decision Making;design;deter alcohol use;disorder prevention;disorder risk;Disparity;effective intervention;efficacy evaluation;efficacy testing;empowerment;evidence base;experience;feasibility testing;Feedback;follow-up;Funding;General Population;hazardous drinking;Health;Health Care Costs;high risk;high risk drinking;high risk population;Home;implementation study;innovation;Intervention;Intervention Studies;Los Angeles;Manuals;Manuscripts;Methodology;migration;model development;Modeling;multi-component intervention;National Institute on Alcohol Abuse and Alcoholism;Native Hawaiian;novel;Pacific Islander;Pattern;pilot test;Policy Maker;Polynesian;Pre-Post Tests;prevent;Prevention;Prevention Research;Prevention strategy;preventive intervention;primary outcome;protective factors;Provider;Public Health;racial population;Randomized;Randomized, Controlled Trials;reduced alcohol use;Reporting;Research;Research Methodology;Risk;Rural;Science;Shapes;social;Social Development;Subgroup;Substance Use Disorder;Testing;therapy design;treatment services;trial design;United States National Institutes of Health;Work;young adult

PROJECT_TITLE: Preventing Alcohol Use Disorders and Alcohol-Related Harms in Pacific Islander Young Adults


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Racial and Ethnic Minority Health Research;Rural Health

PI_NAMEs: MAESTRE, GLADYS E. (contact)

PROJECT_TERMS: Address;Affect;Anthropology;Biomedical Research;Censuses;Clinical Research;Communication;Communities;community advisory board;community based research;community engagement;community involvement;Community Networks;community organizations;design;Diabetes Mellitus;Disease;Educational workshop;equity, diversity, and inclusion;Ethnic Population;Evaluation;Event;evidence base;experience;Facebook;Family;Focus Groups;Fostering;Future;Genetic;Genetic study;Genome;Genomic medicine;Genomics;Goals;Growth;Health;health care delivery;Health Disparities Research;health disparity;health equity;High School Student;Hispanic;Hispanic Populations;Human Genome;Hybrids;improved;Individual;induced pluripotent stem cell;information gathering;interest;Interview;investigator training;Length;literacy;Medical;Medicine;meetings;member;Mental disorders;Methods;Mexican;Mexican Americans;Minority;Minority Groups;Obesity;Participant;Persons;Physicians;Population;precision medicine;Process;recruit;Reporting;Research;Research Methodology;Research Personnel;Research Project Grants;Resources;response;Services;Shapes;South Texas;success;Surveys;tool;Translational Research;Trust;Twitter;underserved area;United States National Institutes of Health;Update;uptake;web site;Woman;Work

PROJECT_TITLE: Community Engagement Core


ADMINISTERING_IC: NR

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Chronic Pain;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Pain Research;Racial and Ethnic Minority Health Research;Social Determinants of Health;Telehealth

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: PROJECT NARRATIVE Despite decades of efforts to reduce racial pain disparities, the pain of Black patients is still undertreated, indicating that this decades-old inequity must be addressed by taking an innovative approach. This work will develop and test a comprehensive framework establishing behavioral coordination (the dyadic and dynamic processes underlying patient-provider communication) as the key mechanism through which patient and provider factors contribute to racial disparities in both patient-centered and clinical pain outcomes. Findings from this work will lay the foundation for developing interventions that target modifiable factors (i.e., patient-provider communication) that can be addressed by leveraging existing infrastructure (i.e., medical training).

PI_NAMEs: HAGIWARA, NAO  (contact);MENDE-SIEDLECKI, PETER

PROGRAM_OFFICER_NAME: AKUBU-ODERO, MAUREEN KALAMBU

PROJECT_TERMS: Address;Agreement;Back;Behavior;Behavior assessment;Behavioral;black patient;Black race;Caring;Clinical;clinical pain;Communication;Consultations;COVID-19;Disparity;disparity elimination;dynamic system;Empathy;experience;Foundations;frontier;Goals;health care disparity;Individual;Inequity;Infrastructure;innovation;Integration Host Factors;Intervention;Knowledge;Link;Medical;Methodology;Modeling;multiple data sources;non-verbal;Outcome;Pain;Pain management;pain outcome;pain perception;pain self-management;patient oriented;patient-clinician communication;Patient-Focused Outcomes;Patients;Pattern;perceived discrimination;Persistent pain;Persons;Postoperative Pain;Prejudice;primary outcome;Procedures;Process;Provider;provider factors;Quality of life;Race;racial disparity;racial health disparity;recruit;Recurrence;Research;Research Design;Research Methodology;satisfaction;secondary outcome;Self Efficacy;social disparities;Stereotyping;Surgeon;surgical pain;Surveys;Techniques;telehealth;Testing;Training;Transcript;Trust;United States National Institutes of Health;verbal;Video Recording;Work

PROJECT_TITLE: Racial Disparities in Pain Care: A Comprehensive Integration of Patient- and Provider-Level Mechanisms with Dyadic Communication Processes Using a Mixed-Methods Research Design

STUDY_SECTION: SPIP

STUDY_SECTION_NAME: Social Psychology, Personality and Interpersonal Processes Study Section[SPIP]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hepatitis;Human Genome;Liver Disease;Nutrition;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Substance Misuse

PI_NAMEs: CURRAN, JOANNE E. (contact)

PROJECT_TERMS: 20 year old;Adult;Affect;Age;Alcohol consumption;Alcoholic Fatty Liver;Apoptotic;Behavior;Behavioral;Biological Factors;Biological Markers;causal variant;Cell Death;Cell Line;Cells;Cellular Stress;Characteristics;chronic liver disease;Cirrhosis;cohort;Complex Mixtures;Data;Development;dietary;Dietary Fats;Disease;disorder risk;early detection biomarkers;Early Diagnosis;endophenotype;Environment;Environmental Risk Factor;epidemiology study;Ethnic Origin;Etiology;Evaluation;Exhibits;Exposure to;Family;Family Study;Fatty acid glycerol esters;Fatty Liver;fatty liver disease;feeding;Fibrosis;Gene Expression Profiling;Genes;Genetic;genetic epidemiology;Genetic Risk;Genetic Transcription;Genome;genome-wide;Genotype;Gills;Goals;health disparity populations;Hepatitis Viruses;Hepatocyte;Hispanic Populations;Image;In Vitro;indexing;Individual;individual variation;induced pluripotent stem cell;Infectious Agent;Insulin Resistance;Knowledge;Life Style;Lipids;Liver;Liver Cirrhosis;Liver Failure;Liver Fibrosis;liver inflammation;Magnetic Resonance Imaging;Measures;Mexican Americans;microbiome;Minority Groups;Modeling;molecular phenotype;multiple omics;Necrosis;non-alcoholic fatty liver disease;Non-Insulin-Dependent Diabetes Mellitus;novel;novel strategies;Obesity;outcome disparities;Participant;Pathway interactions;Persons;Phenotype;Physical activity;pollutant;Population;Populations at Risk;Predisposing Factor;Prevalence;Primary carcinoma of the liver cells;Procedures;Property;Public Health;Reporting;Research;Research Project Grants;response;Risk;Risk Estimate;Risk Factors;sex;single cell sequencing;social determinants;South Texas;Speed;Steatohepatitis;Study Subject;Testing;Toxin;transcriptome sequencing

PROJECT_TITLE: Research Project 1 - Hepatocellular Genetic Epidemiology of Fatty Liver Disease in Hispanics


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Brain Disorders;Congenital Structural Anomalies;Down Syndrome;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Pediatric

ORG_NAME: UNIVERSITY OF COLORADO DENVER

PHR: PROJECT NARRATIVE. Down syndrome (DS), the genetic condition caused by triplication of chromosome 21 (T21), is the most common chromosomal abnormality and a leading cause of intellectual and developmental disability. Although it is accepted that T21 causes genome-wide dysregulation of gene expression programs, little is known about how T21 affects gene expression across different tissues and organs, and how these effects contribute to the developmental and clinical hallmarks of DS. To address this knowledge gap, this proposal aims to generate a comprehensive atlas of tissue-specific gene expression changes caused by T21, matched to detailed metrics of organ development and architecture.

PI_NAMEs: ESPINOSA, JOAQUIN M.;GALBRAITH, MATTHEW D (contact);SULLIVAN, KELLY D.

PROGRAM_OFFICER_NAME: ZOU, SIGE

PROJECT_TERMS: Address;Adult;Affect;Alzheimer's Disease;Architecture;Atlases;Autoimmune Diseases;Biological Models;Blood;Body System;Bone Marrow;Brain;cell type;Cells;Chromosome 21;Chromosome abnormality;Clinical;Code;Communities;Complex;Congenital Heart Defects;Data;data hub;Data Set;Defect;Development;differentiation protocol;Down's Syndrome;Embryo;Ensure;Etiology;Functional disorder;Funding Opportunities;Gene Dosage;Gene Expression;Genes;Genetic Diseases;genome-wide;Grant;Heart;Hematoxylin and Eosin Staining Method;Heterogeneity;Human;Human Chromosomes;human data;Image;Immune system;Immunofluorescence Immunologic;improved;Individual;induced pluripotent stem cell;insight;Intellectual functioning disability;Intestines;Kidney;Knowledge;Link;Liver;Lung;Mediating;Metadata;Modeling;mouse model;Mus;Muscle;Newborn Infant;open data;Organ;organ growth;Organoids;Pathology;Persons;Phenotype;pluripotent stem cell differentiation;Population;programs;Protocols documentation;repository;Research;Research Personnel;Resources;Respiratory Tract Infections;response;Sampling;single-cell RNA sequencing;Skin Tissue;Stains;System;Time;Tissue atlas;Tissue-Specific Gene Expression;Tissues;transcriptome;transcriptome sequencing;Trisomy;Validation;Work

PROJECT_TITLE: Trisomy 21 Model Atlas

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BTC-Y(55)R]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Services;Primary Health Care;Screening and Brief Intervention for Substance Misuse;Substance Misuse

ORG_CITY: Oakland

ORG_NAME: KAISER FOUNDATION RESEARCH INSTITUTE

PHR: NARRATIVE Most patients with alcohol use disorder (AUD) do not receive treatment, including medications for AUD. The proposed pragmatic trial tests population-based primary care interventions designed to increase treatment engagement and decrease alcohol use among non-treatment seeking patients with AUD. Specifically, the trial tests two interventions to implement a patient-centered decision aid and shared decision-making in a primary care sample of 1,500 patients who have 4 or more AUD symptoms documented in their electronic health records, consistent with moderate to severe AUD.

PI_NAMEs: BRADLEY, KATHARINE ANTHONY (contact);LAPHAM, GWEN

PROGRAM_OFFICER_NAME: KWAKO, LAURA ELIZABETH

PROJECT_TERMS: Address;Adoption;Adult;Agreement;alcohol abuse therapy;Alcohol consumption;alcohol screening;alcohol use disorder;Alcoholics Anonymous;Alcohols;arm;barrier to care;Caring;Cessation of life;Clinic;Clinical;comparison intervention;Counseling;COVID-19;Decision Aid;Diagnosis;disability;drinking;DSM-V;effective therapy;Effectiveness;effectiveness-implementation randomized trial;effectiveness/implementation trial;Electronic Health Record;Eligibility Determination;experience;follow-up;high risk;Hybrids;implementation evaluation;implementation facilitators;implementation intervention;implementation outcomes;Individual;International;Intervention;Label;Language;Measures;Medical;Medical Records;National Committee for Quality Assurance;National Institute on Alcohol Abuse and Alcoholism;Outcome;outreach;Pamphlets;patient engagement;patient oriented;Patient-Centered Care;Patients;peer support;Persons;Pharmaceutical Preparations;Play;population based;Population Intervention;pragmatic trial;preference;pressure;Prevalence;Primary Care;primary care clinic;primary care patient;primary care provider;primary care team;primary outcome;Provider;Public Health;Randomized;randomized trial;Recommendation;Recovery;Reporting;Research;Resources;Role;Sampling;screening;screening, brief intervention, referral, and treatment;secondary outcome;shared decision making;social stigma;Social Workers;Stigmatization;Support Groups;Surveys;Symptoms;Testing;Text;therapy design;Thinking;Time;treatment arm;treatment as usual;treatment program;trial comparing;usual care arm;Visit;Washington;web site

PROJECT_TITLE: Systematic Implementation of Patient-centered Care for Alcohol Use Trial: Beyond Referral to Treatment


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cerebrovascular;Dementia;Neurodegenerative;Neurosciences;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: EDINBURGH

ORG_COUNTRY: UNITED KINGDOM

ORG_FIPS: UK

ORG_NAME: UNIVERSITY OF EDINBURGH

ORG_ZIPCODE: EH8 9NY

PHR: PROJECT NARRATIVE Vascular contributors to cognitive impairment and dementia (including Alzheimer’s disease) have a profound societal impact and despite the importance treatment remains limited. Vascular disturbances lead to disconnection and damage of the brains white matter connectivity associated with cognitive impairment. Our evidence suggests that these harmful effects to white matter are mediated by vascular- immune cell alterations and we will aim to study these in detail to provide new information to enable the development of treatments.

PI_NAMEs: FOWLER, JILL H;HALL, CATHERINE ;HORSBURGH, KAREN  (contact);KALARIA, RAJ N;MCCOLL, BARRY

PROGRAM_OFFICER_NAME: YIN, XILING

PROJECT_TERMS: Address;Affect;aging brain;Alzheimer's Disease;Alzheimer's disease risk;Animal Model;Animals;Attenuated;Autopsy;Autoradiography;Behavioral;Biology;Blood - brain barrier anatomy;Blood brain barrier dysfunction;Blood Vessels;Brain;Brain Injuries;Cells;cerebral hypoperfusion;cerebrovascular;Cerebrovascular Circulation;Cerebrum;Chronic;Clinical;clinically relevant;Cognition;Cognitive;cognitive ability;Cognitive deficits;cognitive performance;cohort;CSF1R gene;Data;Dementia;Development;Diagnosis;disability;Disease Progression;effective therapy;Endothelial Cells;Fluorescence;Foundations;Functional disorder;Genetic;Goals;gray matter;hemodynamics;Heterogeneity;Homeostasis;Human;Image;Imaging Device;imaging modality;Immune;immunomodulatory therapies;immunoregulation;Impaired cognition;Impairment;improved;In Situ;In Situ Hybridization;in vivo;Inflammation;insight;intercellular communication;Investigation;Knock-out;Lead;Link;Magnetic Resonance Imaging;Mediating;Microglia;Modeling;Molecular;Monitor;mouse model;Mus;Myelin;neuroimaging;Neuroimmunomodulation;novel;Nuclear;Pathology;Patients;pharmacologic;Phenotype;Population;Positron-Emission Tomography;post stroke;pre-clinical;prevent;programs;prospective;Proteins;radiotracer;Reporter;Research;resilience;RNA;Signal Transduction;single nucleus RNA-sequencing;single-cell RNA sequencing;stroke cognitive outcome;Testing;Therapeutic Intervention;therapy development;Time;Tissues;tool;transcriptomics;translation to humans;TREM2 gene;two photon microscopy;vascular cognitive impairment and dementia;Vascular Endothelial Cell;vascular inflammation;Visualization;white matter;white matter damage;White Matter Disease;Work

PROJECT_TITLE: Altered microglia states and microglia-endothelial cell axis in relation to white matter disease progression in VCID

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AN-Z(55)]


NIH_SPENDING_CATS: Behavioral and Social Science;Biotechnology;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Depression;Endocrine Disruptors;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Major Depressive Disorder;Mental Health;Mental Illness;Prevention;Racial and Ethnic Minority Health Research;Serious Mental Illness;Social Determinants of Health

PI_NAMEs: BLANGERO, JOHN  (contact)

PROJECT_TERMS: addiction;Affect;Age;Air Pollutants;Aromatic Polycyclic Hydrocarbons;Arthritis;Behavior;Characteristics;Chemicals;Clinical;cohort;Cohort Studies;cost;Data;Depressed mood;design;Detection;Diabetes Mellitus;Diagnosis;dietary;Dioxins;Disease;disorder risk;Economic Burden;Environment;Environmental Epidemiology;Environmental Exposure;Environmental Pollutants;Environmental Risk Factor;Ethnic Origin;Etiology;Exposure to;Family;Family Study;Feeling;Fostering;Furans;Genetic;genetic information;genetic pedigree;Genome;genome sequencing;genome-wide analysis;Genomic approach;genomic locus;genomic tools;Genomics;Genotype;Heritability;Hispanic;Human;Immigration;improved;Individual;Infectious Agent;insight;interest;Life;Life Style;Major Depressive Disorder;Measures;member;Mental Depression;Mental disorders;Metals;Mexican Americans;Modification;novel;Nutrient;organochlorine pesticide;persistent organic pollutants;Persons;Pesticides;Pharmaceutical Preparations;Phenotype;Plasma;pollutant;polybrominated diphenyl ether;Polychlorinated Biphenyls;Predisposing Factor;Prevention;Process;Protocols documentation;Recurrence;Research;Research Project Grants;Resources;response;Risk;Risk Factors;Sampling;sex;Signal Transduction;social stressor;Socioeconomic Status;Standardization;Stimulus;Stressful Event;student training;Testing;Time;Toxin;treatment response;Triazines;Variant;whole genome

PROJECT_TITLE: Research Project 2 - Genomic Approaches to Pollutome Effects on Risk of Major Depression in Hispanic Pedigrees


ORG_CITY: DUARTE

ORG_NAME: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE

PHR: PROJECT NARRATIVE The overall goals of this K24 Renewal for the Midcareer Investigator Award in Patient-Oriented Research are to: 1) generate high quality patient-oriented research at the nexus of geriatric oncology and supportive care interventions leveraging new infrastructure underlying the City of Hope’s Center for Cancer and Aging and the national Cancer and Aging Research Group, and 2) to mentor the next generation of geriatric oncology and supportive care scholars and future leaders in patient-oriented research based on new infrastructure to ensure a robust cadre of well-trained scholars in aging and cancer poised to sustain the field into the future.

PI_NAMEs: DALE, WILLIAM  (contact)

PROGRAM_OFFICER_NAME: BAKOS, ALEXIS DIANE

PROJECT_TERMS: Achievement;Address;Age;Aging;aging related disease;American;American Society of Clinical Oncology;Award;Cancer Center;Cancer Patient;cancer therapy;career;career development;Caring;Cessation of life;Cities;clinical implementation;clinical practice;Communities;community setting;Country;Data;Data Reporting;Databases;Dedications;Development;Development Plans;Diagnosis;Doctor of Philosophy;driving force;Educational process of instructing;Elderly;Ensure;Equity;evidence base;Faculty;Fostering;Foundations;Funding;Future;Geriatric Assessment;Geriatrics;Goals;Grant;Guidelines;Health;high risk;human old age (65+);improved;Incidence;Individual;Infrastructure;infrastructure development;Inherited;innovation;Institute of Medicine (U.S.);Intervention;Intervention Trial;Latinx;Lead;Leadership;Learning Skill;Left;Malignant Neoplasms;meetings;member;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Mexico;mid-career faculty;Midcareer Investigator Award in Patient-Oriented Research;multidisciplinary;National Cancer Institute;National Institute on Aging;next generation;older adult;older patient;Oncology;Outcome;patient navigation;patient oriented research;Patient-Centered Care;Patient-Focused Outcomes;Patients;Persons;Population;prevent;programs;Provider;Publications;Publishing;Recommendation;Research;Research Personnel;Resources;Risk;Risk Factors;scale up;Scholarship;Secure;Site;skills;standard of care;Standardization;Supportive care;Surveys;Toxic effect;Toxicity due to chemotherapy;Training;treatment optimization;United States National Institutes of Health;Update;Vision;Work

PROJECT_TITLE: Mentoring the Next Generation of Geriatric Oncology and Supportive Care Researchers in Patient-Oriented Research to Improve the Care of Older Adults with Cancer

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development for Clinicians/Health Professionals Study Section [AGCD-3]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Cancer Genomics;Genetics;Human Genome;Orphan Drug;Ovarian Cancer;Rare Diseases;Women's Health Research

PHR: Project Narrative Cancer-promoting changes in chromosome structure can occur when replication forks are arrested at sites of DNA damage. I discovered that two proteins that act at the stalled fork, FANCM and BRCA1, prevent chromosome rearrangements from forming at stalled forks, and that combined loss of BRCA1 and FANCM is lethal to cells. My goals in this proposal are to identify how this lethal interaction operates in cancer cells, with a view to targeting FANCM as a new therapy in BRCA1 mutant breast or ovarian cancers.

PI_NAMEs: PANDAY, ARVIND  (contact)

PROGRAM_OFFICER_NAME: WEINREICH, MICHAEL DALE

PROJECT_TERMS: Biochemical;BRCA1 gene;cancer cell;Cancer cell line;cancer genome;cancer predisposition;cancer therapy;Cells;Chromatin;Chromosome Structures;Chromosomes;Cleavage Under Targets and Release Using Nuclease;CRISPR/Cas technology;Cytogenetics;Defect;DNA;DNA Damage;DNA replication fork;DNA Structure;Environment;Escherichia coli;Event;FANCD2 protein;Fanconi's Anemia;Gene Conversion;Genes;Genetic;Genetic study;genome-wide;Genomic Instability;Goals;Hereditary Breast and Ovarian Cancer Syndrome;Histones;holistic approach;homologous recombination;Human;Individual;knock-down;Knock-out;Link;Malignant Breast Neoplasm;Malignant neoplasm of ovary;Malignant Neoplasms;Mammalian Cell;Mammalian Chromosomes;Mediating;Molecular;Motor;Mouse Embryonic Stem Cells;Mus;mutant;Mutation;novel;novel therapeutics;Nucleosomes;Outcome;Pathway interactions;Pharmaceutical Preparations;Phase;Phenocopy;Phenotype;Play;Point Mutation;Poly(ADP-ribose) Polymerase Inhibitor;Positioning Attribute;prevent;Process;Protein Dynamics;Proteins;recruit;Regulation;repaired;Reporter;Resistance development;response;Role;Site;Small Interfering RNA;Source;Specificity;success;Susceptibility Gene;synthetic lethal interaction;System;targeted cancer therapy;Techniques;Therapeutic;therapeutic target;tool;translocase;tumor;tumorigenesis;Woman;Work

PROJECT_TITLE: Therapeutic potential of FANCM for BRCA1-linked cancer

STUDY_SECTION_NAME: Transition to Independence Study Section (I)[NCI-I]


NIH_SPENDING_CATS: Bioengineering;Chronic Pain;Nanotechnology;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy;Physical Activity;Physical Injury - Accidents and Adverse Effects;Physical Rehabilitation;Rehabilitation;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_NAME: DREXEL UNIVERSITY

PHR: PROJECT NARRATIVE Chronic pain is a debilitating consequence of spinal cord injury that is refractive to current treatments. This proposal aims to examine how the macrophage activation state can modulate nociceptor excitability, and if altering macrophage phenotype reduce the development of spinal cord injury-induced pain. Understanding these interactions will give us a better understanding of the underlying neuropathology that occurs early after a spinal cord injury in the dorsal root ganglia that leads to pain development or prevention.

PI_NAMEs: DETLOFF, MEGAN R (contact)

PROGRAM_OFFICER_NAME: MOHAPATRA, DURGA PRASANNA

PROJECT_TERMS: Ablation;Adjuvant Therapy;American;Analgesics;Attenuated;axonal sprouting;Cells;Chronic;chronic neuropathic pain;chronic pain;Control Groups;cost;Cyclic AMP;cytokine;Data;Development;Dichloromethylene Diphosphonate;Disease;Encapsulated;Enzyme-Linked Immunosorbent Assay;Exercise;exercise rehabilitation;exosome;extracellular vesicles;Flow Cytometry;Funding;Harvest;Healthcare Systems;Human;Hydrophobicity;Impairment;improved;In Vitro;in vivo;Incidence;Individual;Infiltration;Inflammation;Inflammatory;inhibitor;Injections;injured;Injury;Institute of Medicine (U.S.);Liposomes;Macrophage;Macrophage Activation;Maintenance;Measures;Modeling;Molecular;Nanodelivery;nanopolymer;nanotherapeutic;Neuroimmune;neuronal excitability;Neurons;neuropathology;Nociceptors;Pain;pain behavior;pain reduction;painful neuropathy;Phenotype;phosphodiesterase IV;Physiological;Population;prevent;Prevention;Probability;Process;Rattus;Regulation;Rehabilitation therapy;Reporting;Role;Rolipram;Sensory;Sensory disabilities;Serum;Spinal cord injury;spinal cord injury pain;Spinal Ganglia;Subgroup;System;Technology;Testing;Therapeutic;transmission process;Walking

PROJECT_TITLE: Regulation of SCI-induced pain by macrophages and exercise

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]