NIH_SPENDING_CATS: Neurosciences

ORG_CITY: NEW HAVEN

ORG_DEPT: PHYSIOLOGY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative Mitochondrial metabolism is implicated in human diseases including brain disorders, however, while protein-mediated metabolite translocation directly governs metabolism within this organelle, the process is poorly characterized. By applying our metabolomics-based approach to characterize the largest human mitochondrial transporter SLC25 family in cells, with a focus on neuronal cells, our research promises to discover new molecular mechanisms in mitochondrial metabolite transport, enabling new directions in the pathophysiology underlying brain disorders.

PI_NAMEs: SHEN, HONGYING  (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TERMS: Adopted;Area;Biochemistry;Biology;Brain Diseases;career;Cells;Cellular biology;Family;flexibility;frontier;Functional disorder;Funding Mechanisms;gain of function;Genes;Glutathione;Goals;Human;human disease;In Vitro;in vitro Model;Induced pluripotent stem cell derived neurons;Laboratories;Life;Ligands;loss of function;Mediating;Metabolism;metabolomics;Mitochondria;mitochondrial membrane;mitochondrial metabolism;Molecular;Neurons;Organelles;Process;programs;Protein Family;Proteins;Research;Resolution;Role;Structure;Synapses;System;uptake

PROJECT_TITLE: A systems approach to decode mitochondrial metabolite transport

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


ADMINISTERING_IC: MH

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Mental Illness;Physical Injury - Accidents and Adverse Effects;Prevention;Psychosis;Schizophrenia;Serious Mental Illness;Social Determinants of Health;Violence Research

ORG_CITY: AUGUSTA

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: AUGUSTA UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE The development of strategies and interventions for preventing or minimizing violent behavior in individuals with psychotic disorders has been limited, in part, by a lack of information about the effects of antipsychotic medications, and in particular clozapine, on violent acts in community settings. In this project, we will determine whether clozapine, when administered in real-world settings, decreases the risk for violent acts in individuals with schizophrenia at high risk for violence when compared to treatment with other antipsychotic medications, and investigate whether previously identified change mechanisms are operative in the effectiveness setting. Examining clozapine in this way will foster a better understanding of the effects of clozapine on violent acts in community settings and allow us to test a scalable intervention and service delivery approaches that can be broadly implemented using typically available resources, and as such has significant public health implications.

PI_NAMEs: MCEVOY, JOSEPH PATRICK (contact)

PROGRAM_OFFICER_NAME: RUDORFER, MATTHEW V

PROJECT_TERMS: Address;Aggressive behavior;Alcohol consumption;Alcohols;Antipsychotic Agents;antisocial behavior;Behavior;blind;Clinical;Clinical Research;clinical research site;Clinical Trials;clinically relevant;Clozapine;Collaborations;community partners;community setting;community violence;Data;Delusions;Development;Diagnostic;Disparate;Effectiveness;effectiveness outcome;effectiveness study;efficacy trial;Ensure;Fostering;Future;high risk;Hostility;Human Resources;improved;Impulsivity;Individual;individual patient;interest;Intervention;intervention delivery;Interview;Link;Measures;Multi-Institutional Clinical Trial;Murder;Neurobiology;New York;open label;Outcome;Outcome Measure;Outpatients;Pathway interactions;Patients;Persons;Pharmaceutical Preparations;Populations at Risk;Positron-Emission Tomography;prevent;primary outcome;Property;Protocols documentation;psychopathic personality;Psychoses;psychotic;Psychotic Disorders;Public Health;Randomized;randomized, clinical trials;Research;Research Domain Criteria;Resources;Risk;Risk Reduction;Running;Safety;Sample Size;Schizophrenia;Sedation procedure;Self-Injurious Behavior;service delivery;Site;social stigma;Spectrum Analysis;substance use;Symptoms;Syndrome;Testing;Time;treatment as usual;treatment effect;Violence;violence prevention;Vulnerable Populations;Work

PROJECT_TITLE: 7/7 Clozapine for the Prevention of Violence in Schizophrenia: a Randomized Clinical Trial


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Dietary Supplements;Hematology;Microbiome;Neurosciences;Nutrition;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn

ORG_CITY: SEATTLE

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Preterm infants < 32 weeks’ gestation are at high risk for both transfusions and iron deficiency, both of which may independently contribute to poor neurodevelopmental outcomes. Our overarching goal is to develop a therapeutic pathway to minimize transfusions while maintaining iron sufficiency, thereby optimizing developmental outcomes in these infants. We hypothesize that treatment of infants < 32 weeks’ gestation with a combination of Darbe plus one of two slow-release intravenous iron preparations, ferumoxytol (FMX) or low molecular weight iron dextran (LMW-ID) will 1) be safe, 2) decrease or eliminate transfusions, 3) maintain iron sufficiency, and 4) improve neurodevelopment.

PI_NAMEs: JUUL, SANDRA E (contact)

PROGRAM_OFFICER_NAME: SANTOS SCHMIDT, AUGUSTO FREDERICO

PROJECT_TERMS: 2 year old;absorption;Academy;Adherence;Adult;Adverse event;Aftercare;Age;American;Anemia;Auditory Brainstem Responses;Binding;Birth;Blood Transfusion;Blood Volume;Brain;Carbohydrates;Combined Modality Therapy;Development;dosage;Dose;Enrollment;Erythrocytes;Erythropoiesis;Erythropoietin;Evaluation;experience;falls;FDA approved;Ferritin;Ferrous Sulfate;ferumoxytol;fetal;Formulation;gastrointestinal;Goals;Growth;Guidelines;gut inflammation;gut microbiome;gut microbiota;Hematocrit procedure;high risk;Hospitalization;Hospitals;immune function;improved;Infant;Infant Development;infant outcome;Intestines;Intravenous;Iron;iron deficiency;Iron deficiency anemia;Iron Overload;iron supplement;iron supplementation;Iron-Dextran Complex;life span;Liver;Long-Term Effects;Malabsorption Syndromes;metabolic rate;microbiome;Molecular Weight;Monitor;Movement;myelination;neonate;neurodevelopment;Neurotransmitters;Oral;oral supplementation;Outcome;oxidative damage;Pathway interactions;Pediatrics;Pharmaceutical Preparations;phase 2 study;postnatal;Pregnancy;Pregnant Women;premature;Premature Infant;Preparation;prevent;primary outcome;Process;Production;Recommendation;saccharated ferric oxide;Safety;skills;standard care;stool sample;Supplementation;Testing;Therapeutic;Tissues;Transfusion;Venous blood sampling

PROJECT_TITLE: Trial of Darbepoetin plus slow-release intravenous iron to decrease transfusions and improve iron status and neurodevelopment in preterm infants

STUDY_SECTION: HTBT

STUDY_SECTION_NAME: Hemostasis, Thrombosis, Blood Cells and Transfusion Study Section[HTBT]


ADMINISTERING_IC: NR

ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Biodefense and Related Countermeasures;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Vaccines;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Immunization;Infectious Diseases;Influenza;Mental Health;Mental Illness;Pneumonia and Influenza;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health;Vaccine Related

ORG_CITY: CHESTNUT HILL

ORG_NAME: BOSTON COLLEGE

ORG_STATE: MA

PHR: Project Narrative In collaboration with East Boston Neighborhood Health Center the proposed study aims to evaluate the effectiveness of a motivational interviewing-based behavioral intervention to reduce vaccine hesitancy and increase COVID-19 and influenza vaccine uptake in Latinx adults with mental illness. Using a pragmatic multiple-period, cluster-randomized crossover trial design, this study will be a significant step towards practical, evidence-based and sustainable interventions for increasing vaccine acceptance and uptake among priority populations.

PI_NAMEs: CALVO, ROCIO ;DAVISON, KIRSTEN  (contact);HANEUSE, SEBASTIEN

PROGRAM_OFFICER_NAME: GODETTE, DIONNE

PROJECT_TERMS: Academia;Address;Adopted;Adult;Automobile Driving;Behavior Therapy;behavioral health;behavioral health intervention;booster vaccine;Boston;Caring;clinical practice;Collaborations;college;Communicable Diseases;Communities;Counseling;Country;Coupled;COVID-19;COVID-19 morbidity;COVID-19 pandemic;COVID-19 vaccination;COVID-19 vaccine;Cross-Over Trials;cultural values;Death Rate;design;Development;Diagnosis;Discrimination;effectiveness evaluation;effectiveness testing;Electronics;Elements;evidence base;experience;Federally Qualified Health Center;global health;health care settings;health disparity;Health Personnel;Health Services;high risk;Hispanic;hospitalization rates;Individual;Influenza vaccination;influenza virus vaccine;innovation;integrated care;Intervention;intervention effect;Knowledge;Language;Latinx;Latinx population;Leadership;Massachusetts;Mental disorders;Mental Health;Modeling;Morbidity - disease rate;mortality;motivational enhancement therapy;Neighborhood Health Center;Neighborhoods;novel;pandemic disease;Pathway interactions;Patients;Pattern;person centered;point of care;Population;Positioning Attribute;programs;Protocols documentation;Provider;Randomized;Research;Research Personnel;response;Risk;Role;Safety;SARS-CoV-2 infection;scale up;seasonal influenza;Series;Services;social health determinants;Spanish;Structural Racism;theories;Time;Training;Translations;Trauma;treatment as usual;trial design;Trust;Universities;uptake;Vaccinated;Vaccination;vaccine acceptance;vaccine access;vaccine distribution;vaccine hesitancy;vaccine refusal;Vaccines;Vulnerable Populations;working group;World Health Organization

PROJECT_TITLE: Leveraging community-based behavioral health to increase vaccine uptake in Latinx adults with mental illness

STUDY_SECTION: HPC

STUDY_SECTION_NAME: Health Promotion in Communities Study Section[HPC]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer

ORG_CITY: RICHMOND

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: PROJECT NARRATIVE The Massey Cancer Center (MCC) Integrative Training in Cancer Biology program aims to provide breakthrough opportunities to empower predoctoral and postdoctoral scientists from traditionally underrepresented groups to tackle the most difficult scientific challenges in addressing the nation’s cancer burden. Trainees will be oriented to the importance of integrating bidirectional community engagement in all research efforts and the conscious role scientists have in addressing cancer disparities. These predoctoral and postdoctoral scientists will also benefit from research training in the most contemporary approaches in cancer biology as well as professional career development mentoring with a highly select group of successful MCC scholars.

PI_NAMEs: ATFI, AZEDDINE  (contact)

PROGRAM_OFFICER_NAME: BOULANGER-ESPEUT, CORINNE A

PROJECT_TERMS: Cancer Biology;Training Programs

PROJECT_TITLE: Integrative Training Program in Cancer Biology

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


NIH_SPENDING_CATS: Cancer;Clinical Research;Immunotherapy;Prostate Cancer;Urologic Diseases

ORG_CITY: SAINT LOUIS

ORG_DEPT: SURGERY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative Our study uncovered that tumor-insensitive T cells could be reinvigorated by overcoming ACK1-CSK kinase signaling cascade by genetic as well as pharmacological inhibition of ACK1. This distinct mode of enhancing immune surveillance by ACK1 inhibitor could be a new cancer immunotherapy for castration resistant prostate cancer.

PI_NAMEs: MAHAJAN, NUPAM P (contact)

PROGRAM_OFFICER_NAME: ZAMISCH, MONICA

PROJECT_TERMS: abiraterone;Ablation;ACK1 Gene;adaptive immune response;androgen deprivation therapy;androgen independent prostate cancer;antagonist;anti-tumor immune response;Antitumor Response;AR gene;Back;Cancer Etiology;cancer immunotherapy;Cancer Patient;CD8-Positive T-Lymphocytes;Cell Separation;Cessation of life;chemokine;Chemotactic Factors;Clinical Trials;Data;Deposition;Enhancers;enzalutamide;Epigenetic Process;Exhibits;Failure;Genetic;Growth;Immune;immune cell infiltrate;immune checkpoint blockade;Immune response;Immune system;Immunologic Surveillance;inhibitor;insight;Interleukin-2;Knock-in;Knockout Mice;Ligand Binding;Lymphocyte Activation;Lymphocyte-Specific p56LCK Tyrosine Protein Kinase;Malignant neoplasm of prostate;Mediating;men;Modality;mouse model;Mus;neoplastic cell;novel;Oral;Organoids;paracrine;Patients;Peripheral Blood Mononuclear Cell;pharmacologic;Phosphorylation;Phosphotransferases;Process;Production;Property;Prostate;prostate cancer model;Prostatic Neoplasms;Protein Tyrosine Kinase;Protein Tyrosine Phosphatase;protein-tyrosine kinase c-src;PTEN gene;PTPN11 gene;Receptor Activation;Receptor Signaling;Recurrent disease;Refractory;Resistance;Resistance development;restraint;Role;Series;Signal Transduction;Site;small molecule inhibitor;src-Family Kinases;suicidal;T-Cell Activation;T-Cell Receptor;T-Lymphocyte;Therapeutic;TP53 gene;trafficking;transcriptome sequencing;Treatment Efficacy;tumor;tumor growth;tumor-immune system interactions;ubiquitin-protein ligase;Ubiquitination;virtual

PROJECT_TITLE: Targeting a Novel Signaling Nexus pACK/pCSK/pLCK in Immune Checkpoint Blockade (ICB)-Resistant Prostate Cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-TIR-W(01)Q]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE Data in structural biology is subject to significant systematic errors that limit its accuracy and, ultimately, limit the conclusions that can be derived from it. Creating simulation technologies that can account for these errors will have significant impact on three fronts: 1) correcting radiation damage effects from a new and information- rich mode of data collection, 2) capturing and correcting non-isomorphism by defining low-parameter-count simulations that trace molecular motions through their accessible energy landscape, 3) discriminating hotly contested alternative interpretations such as the presence or absence of a bound ligand, by reducing electron density error with simulation-based solvent and protein models.

PI_NAMEs: HOLTON, JAMES M (contact)

PROGRAM_OFFICER_NAME: TAYLOR, VERONICA

PROJECT_TERMS: 3-Dimensional;Active Sites;Area;Back;beamline;Binding;Biological Models;Biological Process;Biology;Breathing;Catalysis;Chemistry;computerized data processing;conformer;Cryoelectron Microscopy;Crystallography;Data;Data Collection;data modeling;Data Set;density;Deposition;Detection;detector;Dimensions;Discrimination;Disease;Dose;electron density;electron diffraction;Electrons;experimental study;Humidity;Hybrids;Hydrogen;Image;improved;inhibitor;insight;interest;Ligand Binding;Ligands;Lighting;Lipids;macromolecule;Maps;Membrane Proteins;Metals;method development;Methodology;Methods;Modeling;models and simulation;Modernization;Molecular;Molecular Conformation;Molecular Structure;Motion;Movement;multiple data sources;next generation;Noise;non-Native;Paint;Periodicals;Photons;prevent;Proteins;Protocols documentation;Radiation induced damage;Reaction;Reporting;Resolution;restraint;Roentgen Rays;Sampling;Series;Side;Signal Transduction;simulation;Solvents;Source;Spottings;structural biology;Structure;success;Surface;Synchrotrons;Syncope;Techniques;Technology;Temperature;terabyte;Testing;three dimensional structure;three-dimensional modeling;Time;tomography;vector;virtual;Water;Work

PROJECT_TITLE: Eliminating Critical Systematic Errors In Structural Biology With Next-Generation Simulation

STUDY_SECTION: MSFC

STUDY_SECTION_NAME: Macromolecular Structure and Function C Study Section[MSFC]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Antimicrobial Resistance;Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Clinical Research;Emerging Infectious Diseases;Hematology;Infectious Diseases;Lung;Nanotechnology;Orphan Drug;Patient Safety;Pneumonia;Pneumonia and Influenza;Rare Diseases;Sepsis

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE We are investigating a highly innovative therapeutic to counteract detrimental hyperinflammation and lung injury in severe hospital- and ventilator-associated pneumonias caused by the leading multidrug-resistant Gram-negative bacterial pathogens Pseudomonas aeruginosa and Acinetobacter baumannii. Our biocompatible and biodegradable human macrophage membrane-coated nanoparticles (MΦ-NP) neutralize bacterial toxins, LPS, and host-derived pro-inflammatory cytokines to control inflammatory damage and promote effective immune clearance of the pathogens. This novel nanotherapeutic drug concept can reduce one of the most common causes of ICU mortality in the present era of rising antimicrobial resistance.

PI_NAMEs: MEIER, ANGELA ;NIZET, VICTOR  (contact);ZHANG, LIANGFANG

PROGRAM_OFFICER_NAME: XU, ZUOYU

PROJECT_TERMS: 2019-nCoV;3-Dimensional;Acinetobacter baumannii;Acinetobacter baumannii pneumonia;Acute Respiratory Distress Syndrome;Alveolar Macrophages;Anti-Bacterial Agents;Antibiotics;Antimicrobial Resistance;Apoptosis;Bacterial Pneumonia;Bacterial Toxins;Binding;biodegradable polymer;biomaterial compatibility;Biomimetics;Blood donor;Brain Injuries;Carbapenems;Caring;cell injury;Cell membrane;Cessation of life;Clinical;clinical development;Clinical Management;Complication;Confined Spaces;Critical Illness;cytokine;cytotoxic;Development Plans;Drug Kinetics;Endothelial Cells;Endothelium;Epithelial Cells;Epithelium;experience;extracellular;Goals;Hospital Mortality;Hospitalization;Hospitals;Human;human induced pluripotent stem cells;immune clearance;Immune system;Immunologics;in vivo evaluation;Infection;Inflammation;Inflammatory;Inflammatory Response;Inflammatory Response Pathway;Influenza;innovation;Intensive Care Units;Intravenous;Invaded;Investigational New Drug Application;Knowledge;Life;Lipid Bilayers;Lipopolysaccharides;Lung;Lung infections;lung injury;lung preservation;Macrophage;Mechanical ventilation;Medical;Membrane;Morbidity - disease rate;mortality;mouse model;Multi-Drug Resistance;multidrug-resistant Pseudomonas aeruginosa;Mus;nano;nanoparticle;nanotherapeutic;neutrophil;Nosocomial pneumonia;novel;novel therapeutics;Operative Surgical Procedures;Organism;Organoids;pathogen;pathogenic bacteria;Pathway interactions;Patient Admission;Patients;Phagocytosis;Pharmaceutical Preparations;Pharmacodynamics;pharmacokinetics and pharmacodynamics;Phase I Clinical Trials;Pneumonia;pneumonia model;preservation;Production;Proliferating;Pseudomonas aeruginosa;Pseudomonas aeruginosa pneumonia;Publishing;Pulmonary Inflammation;receptor;Resistance development;Respiratory Burst;response;septic;septic patients;Septic Shock;Serum;Structure;Structure of parenchyma of lung;Surface;Therapeutic;therapeutic nanoparticles;Tissue Preservation;Tissues;Toxic effect;ventilator-associated pneumonia;Viral Pneumonia;Work

PROJECT_TITLE: Biomimetic Macrophage Membrane-Coated Nanosponges: A Novel Therapeutic for Multidrug-Resistant Pseudomonas aeruginosa and Acinetobacter baumannii Hospital-Associated Pneumonia


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular

ORG_CITY: DAVIS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Project Narrative This goal of the Training Program is to produce a new blend of scientists in cardiovascular research who are poised to exchange ideas, expertise, and techniques leading to the direct and effective flow and translation of basic science discoveries into clinical testing and applications, as well as generate mechanistic hypotheses that can be tested at the basic cellular level, directly derived from clinical research.

PI_NAMEs: CADEIRAS, MARTIN  (contact);LIEM, DAVID A.

PROGRAM_OFFICER_NAME: WOO, SEUNG KYOON

PROJECT_TITLE: Training Program in Basic and Translational Cardiovascular Science

STUDY_SECTION: NITM

STUDY_SECTION_NAME: NHLBI Institutional Training Mechanism Study Section[NITM(JA)]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

PHR: Project Narrative. The ability to navigate spatial environments is amongst the most fundamental of tasks in human behavior. However, much of what is known about its underlying neural mechanisms comes from studies of rodents, species that differ from primates considerably in their neural architecture, sensory experience and navigational behaviors. This innovative proposal seeks to address this considerable gap by explicating how the primate brain integrates mechanisms for representing space through visual exploration and physical navigation.

PI_NAMEs: MILLER, CORY T (contact);ZHANG, KECHEN

PROGRAM_OFFICER_NAME: DAVID, KAREN KATE

PROJECT_TITLE: Spatial exploration and navigation in the primate hippocampus


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Cannabinoid Research;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Drug Abuse (NIDA only);Maternal Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Substance Misuse;Women's Health Research

ORG_CITY: BALTIMORE

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: Narrative The proposed project aims to more clearly define if and how women change their cannabis use after recognition of pregnancy by following women throughout their pregnancy and quantifying use each month. Additionally, we intend to identify potentially modifiable factors that are associated with continued cannabis use during pregnancy in order to improve counseling and treatment efforts with a goal of improving pregnancy outcomes. We will also compare birth outcomes between women who continue to use, quit using or never used cannabis during pregnancy.

PI_NAMEs: MARK, KATRINA  (contact)

PROGRAM_OFFICER_NAME: DUNSTON, SHEBA KING

PROJECT_TERMS: Abstinence;Admission activity;Adverse effects;adverse outcome;adverse pregnancy outcome;Affect;Area;Back;Birth;Birth Weight;California;Cannabinoids;Cannabis;Categories;Characteristics;clinical research site;cohort;Collaborations;Collection;comparison group;Control Groups;Counseling;Cross-Sectional Studies;Data;Demographic Factors;Development;Dose;drug testing;Electronics;Enrollment;Evaluation;experience;fetal marijuana exposure;First Pregnancy Trimester;Frequencies;Future;Gestational Age;Goals;Head circumference;Health;Health Personnel;Health Status;high risk;High Risk Woman;improved;innovation;Institution;Intervention;Knowledge;marijuana use;marijuana use disorder;marijuana use in pregnancy;Maryland;Maternal and Child Health;Maternal Health;maternal outcome;Measures;Medical;Medicine;Mental Health;Modeling;Motivation;Neonatal Intensive Care Units;neonatal outcome;neonate;neurodevelopment;Newborn Infant;Outcome;Participant;Patient Self-Report;Pattern;Perception;Persons;Placenta;Positioning Attribute;Postpartum Period;Pregnancy;Pregnancy Outcome;pregnant;Pregnant Women;Prenatal care;prenatal exposure;Professional Organizations;prospective;Provider;Readiness;Recommendation;Recording of previous events;recruit;Reporting;Research;Research Personnel;Risk;risk perception;screening;Site;social;social health determinants;substance use;success;Surveys;Symptoms;Tetrahydrocannabinol;Time;timeline;Urine;Variant;virtual;Woman;women's treatment

PROJECT_TITLE: Trajectories of Cannabis Use in Pregnancy

STUDY_SECTION: ARM

STUDY_SECTION_NAME: Addiction Risks and Mechanisms Study Section[ARM]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Immunotherapy;Infectious Diseases;Lung

ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: NARRATIVE Regulatory T cells (Tregs) are emerging as key players in facilitating tissue repair after infection or injury, but how these cells recognize damage remains unclear. This application will characterize a new signaling pathway that enables Tregs to sense lung infection and/or damage and respond appropriately.

PI_NAMEs: BARTON, GREGORY M (contact)

PROGRAM_OFFICER_NAME: JIANG, CHAO

PROJECT_TERMS: adaptive immunity;Adopted;Adoptive Transfer;Agonist;Alleles;Amphiregulin;Area;Autoantigens;Bleomycin;Cell Physiology;Cell Therapy;Cells;Cellular biology;Clinical;Computational Biology;Cues;cytokine;Cytokine Receptors;Data;Detection;EGF gene;Family;Family member;Foundations;Gene Expression;Gene Expression Profile;gene repair;Genes;Heterogeneity;Homeostasis;Human;IL18 gene;Immune;Immune Tolerance;Impairment;improved;In Vitro;Infection;Inflammation;Influenza;Injury;interest;Interleukin-1;Knockout Mice;Ligands;Link;Lung;Lung infections;lung injury;lung repair;Maintenance;Mediating;member;Metabolism;Modality;Modeling;Molecular Chaperones;Mus;Muscle;mutant;Mutant Strains Mice;Natural Immunity;next generation sequencing;Nucleic Acids;pathogen;Population;receptor;Regulatory T-Lymphocyte;repair function;repaired;Reporter;response;RNA;Role;sensor;Signal Induction;Signal Pathway;Signal Transduction;single-cell RNA sequencing;T cell response;T-Cell Proliferation;Testing;Therapeutic;therapeutic evaluation;tissue repair;Tissues;TLR7 gene;Treg therapy;Viral;viral RNA;Work

PROJECT_TITLE: Control of Regulatory T Cell Function by Toll-Like Receptor 7

STUDY_SECTION: CMIB

STUDY_SECTION_NAME: Cellular and Molecular Immunology - B Study Section[CMIB]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetic Testing;Genetics;Human Genome;Precision Medicine;Prevention;Skin Cancer

ORG_DEPT: DERMATOLOGY

PHR: NARRATIVE DESCRIPTION Melanocytic nevi (moles) are mimics and precursors of melanoma, the deadliest of the common forms of skin cancer. Early diagnosis improves survival rates of melanoma, but diagnosing moles and melanoma is not always clear-cut, and markers that would improve accuracy of diagnosis are inadequate. This research builds detailed maps of moles and melanoma that combine gene expression and tissue architecture of the tumors and their surrounding tissues to understand how the tumors develop and to identify markers for a more reliable diagnosis, ultimately leading to improved patient outcomes.

PI_NAMEs: KIURU, MAIJA HELENA TUULIA (contact)

PROGRAM_OFFICER_NAME: LI, JERRY

PROJECT_TERMS: Address;Architecture;Benign;Biological Markers;Biological Sciences;Biology;biomarker development;biomarker identification;CDK2 gene;cell type;Cells;cellular imaging;Cellularity;Characteristics;Chromosome Mapping;Complex;Coupled;Cutaneous Melanoma;Cytokeratin;Data;Dermis;Development;Diagnosis;diagnostic accuracy;diagnostic biomarker;diagnostic criteria;Diagnostic Errors;diagnostic value;differential expression;digital;Early Diagnosis;Endothelial Cells;Epidermis;Epithelial Cells;Fibroblasts;Gene Combinations;Gene Expression;Gene Expression Profile;Gene Expression Profiling;gene panel;Genes;Goals;imaging platform;Immune;Immunohistochemistry;improved;innovation;keratinocyte;Knowledge;Malignant - descriptor;malignant melanocyte;Malignant Neoplasms;Maps;MART-1 Tumor Antigen;melanocyte;Melanocytic Neoplasm;Melanocytic nevus;Melanoma;melanoma biomarkers;Metastatic Melanoma;Methodology;Mole the mammal;Morphology;Neoplasm Metastasis;Neoplasms;neoplastic cell;Nevi and Melanomas;Nevus;novel diagnostics;novel marker;Patient-Focused Outcomes;Pattern;Peripheral;Population;preferentially expressed antigen in melanoma;preservation;prevent;PTPRC gene;Regulation;Research;Resolution;Role;single cell sequencing;single-cell RNA sequencing;Skin Cancer;Space Perception;Structure;success;Survival Rate;Testing;Tissues;Transcript;transcriptome;tumor;Tumor Biology;tumor heterogeneity;Tumor Markers;tumor microenvironment;tumor progression;Tumor Tissue;tumor-immune system interactions

PROJECT_TITLE: Spatial Profiling of Melanocytic Tumors and Their Microenvironment


NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: ALBANY

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT ALBANY

ORG_STATE: NY

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because understanding the causes, constraints and consequences of bacterial recombination and the extent to which it influences how new lineages are formed are expected to give rise to new types of treatment for diseases that specifically target this process. Thus, this proposal is relevant to the part of NIGMS’s mission that pertains to fostering fundamental creative discoveries and innovative research strategies in genome evolution and genetic mechanisms to help reduce the burden of disease and ultimately protect human health.

PI_NAMEs: ANDAM, CHERYL MARIE P (contact)

PROGRAM_OFFICER_NAME: ADKINS, RONALD

PROJECT_TITLE: Population and evolutionary dynamics of recombining genes and alleles in bacteria

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-K(55)R]


NIH_SPENDING_CATS: Biotechnology;Cystic Fibrosis;Gene Therapy;Genetics;Lung;Pediatric;Rare Diseases

ORG_CITY: EAST LANSING

ORG_NAME: MICHIGAN STATE UNIVERSITY

ORG_STATE: MI

PHR: PROJECT NARRATIVE / PUBLIC HEALTH RELEVANCE STATEMENT Cystic fibrosis (CF) is a common genetic disease caused by a defect in the membrane pore protein CFTR, and CF lung disease is the most common cause of death in CF patients. This proposal addresses how mutation of a membrane pore protein leads to infection and bacterial growth, and how these characteristic features of CF lung disease differ in the different regions of the lung. Defining regional differences in development of CF lung disease is essential to understand the disease's origins and to identify new therapeutic pathways for CF.

PI_NAMEs: LI, XIAOPENG  (contact)

PROGRAM_OFFICER_NAME: LACHOWICZ-SCROGGINS, MARRAH ELIZABETH

PROJECT_TERMS: Address;airway epithelium;airway obstruction;airway surface liquid;Animal Model;Bacterial Infections;Bicarbonates;Cause of Death;cell type;Cells;cellular targeting;Cellular Tropism;Characteristics;chemical property;chronic infection;Clinical Data;Complementary DNA;Cystic Fibrosis;cystic fibrosis airway epithelia;cystic fibrosis patients;Cystic Fibrosis Transmembrane Conductance Regulator;Data;Defect;Dependovirus;Development;Diameter;Disease;DNA Sequence Alteration;Engineering;Epithelial Cells;experience;Family suidae;Gene Delivery;Genetic Diseases;Goals;Growth;Host Defense;Host Defense Mechanism;Human;human disease;Impairment;In Vitro;in vivo;Infection;Inflammatory;Injections;Iowa;Lung;Lung Diseases;Lung infections;Mediating;Membrane;Modeling;Mucous body substance;Mus;Mutate;Mutation;novel;novel therapeutics;Organ;Pathogenesis;Pathologic;Pathway interactions;physical property;Play;porcine model;Pore Proteins;preclinical study;prevent;Property;public health relevance;Pulmonary Cystic Fibrosis;regional difference;Regulation;respiratory examination;restoration;Role;Sampling;Satellite Viruses;Serotyping;stem cells;targeted delivery;Testing;Therapeutic;Tissues;Trachea;transduction efficiency;translational potential;Tropism;vector;Viral Vector;Viscosity

PROJECT_TITLE: Role of disrupted ASL pH regulation in small airways in CF lung disease pathogenesis

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Childhood Leukemia;Hematology;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: PROJECT NARRATIVE Leukemia remains difficult to treat, indicating an urgent need to develop new therapeutic strategies; thus, the overarching goal of the proposed research is to explore leukemia metabolism and develop novel biomarkers and therapeutic strategies. Our preliminary data demonstrates that specific metabolic pathways driving serine biosynthesis are increased in leukemia; these reflect vulnerabilities that we can develop imaging biomarkers to target. Our proposed work will facilitate future patient-specific treatment planning and novel experimental strategies for cancer treatment.

PI_NAMEs: KESHARI, KAYVAN R (contact);KHARAS, MICHAEL

PROGRAM_OFFICER_NAME: TANDON, PUSHPA

PROJECT_TERMS: Acute Myelocytic Leukemia;acute myeloid leukemia cell;Address;Anabolism;Automobile Driving;Biological Markers;cancer therapy;Carbohydrates;Carbon;Cell Compartmentation;cell growth;Cell Line;Cells;Cellular Metabolic Process;chemotherapy;Clinical;Collaborations;Companions;Complex;Data;dehydroascorbate;Dependence;design;Development;Diet;Disease;Environment;Enzyme Inhibition;Enzymes;FLT3 gene;Future;Genetic;Genetic Variation;Glucose;Glutamine;Glycolysis;Goals;Hematopoietic;Heterogeneity;Human;human cord blood CD34+ cell;Image;imaging approach;imaging biomarker;in vivo;individualized medicine;innovation;insight;Isocitrate Dehydrogenase;Isotopes;Knowledge;leukemia;leukemic stem cell;Link;Lipids;Magnetic Resonance;Magnetic Resonance Imaging;Malignant Neoplasms;mass spectrometric imaging;Measures;Mediating;Metabolic;metabolic abnormality assessment;metabolic imaging;Metabolic Pathway;Metabolism;MLL-AF9;Modeling;Motivation;Mus;Mutation;Myeloid Leukemia;new therapeutic target;novel;novel marker;novel strategies;novel therapeutic intervention;novel therapeutics;Nutrient;Organism;overexpression;Oxidation-Reduction;Oxidative Stress;Oxidative Stress Induction;Pathogenesis;Pathway interactions;Patients;Pharmaceutical Preparations;pharmacologic;Phosphoglycerate dehydrogenase;programs;Publishing;Pyruvate;Relapse;Research;Resistance;response;Role;Sampling;Science;Serine;Sorting;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;stem cell biology;stem cells;stemness;stress state;Therapeutic;therapeutic development;therapy resistant;tool;Translating;treatment planning;treatment response;tumor metabolism;Visualization;Work

PROJECT_TITLE: Interrogation of the oxidative-stress-induced leukemia program in vivo using metabolic imaging

STUDY_SECTION: IPCA

STUDY_SECTION_NAME: Imaging Probes and Contrast Agents Study Section[IPCA]


NIH_SPENDING_CATS: Bioengineering;Genetics

ORG_CITY: Princeton

ORG_DEPT: PHYSICS

ORG_NAME: PRINCETON UNIVERSITY

ORG_STATE: NJ

PHR: Project Narrative (Public Health Relevance Statement) Gene regulatory networks underlie animal development and physiological homeostasis, and perturbations in these networks cause developmental defects and pernicious diseases such as cancer. The key to curing such conditions is our ability to elucidate underlying mechanisms, particularly regarding transcriptional regulation. Here we propose to uncover the rules governing one of the most fundamental aspects of transcriptional control— the role of chromosome organization and nuclear architecture on the dynamics of gene activity—to regulate and re-engineer transcriptional programs underlying development and disease processes.

PI_NAMEs: GREGOR, THOMAS  (contact)

PROGRAM_OFFICER_NAME: PHILLIPS, ANDRE W

PROJECT_TERMS: 3-Dimensional;Affect;Alleles;Animals;Architecture;Automobile Driving;Biological Assay;Biophysics;Cell Differentiation process;cell type;Cells;Cellular biology;Characteristics;Chromatin;Chromosome Structures;Color;Complex;Computer Analysis;Crowding;Defect;Development;Developmental Biology;Developmental Process;Disease;DNA;DNA Sequence;Drosophila genus;Elements;Embryo;Embryonic Development;Engineering;Enhancers;Environment;Event;fly;Frequencies;functional gain;Funding;Gene Activation;Gene Expression;Gene Expression Profile;Gene Expression Regulation;gene regulatory network;Genes;Genetic Enhancer Element;Genetic Transcription;Genome;genome editing;genomic locus;Genomics;Goals;Homeostasis;Image;imaging approach;imaging modality;Individual;interest;Investigation;Label;Link;Malignant Neoplasms;Mammals;Measurement;Measures;Messenger RNA;Molecular;Molecular Conformation;Monitor;novel;Nuclear;Organism;Outcome;Output;Pattern;Population;Positioning Attribute;Prevalence;Process;Productivity;programs;promoter;Property;public health relevance;Regulation;Regulatory Element;Reproducibility;Resolution;RNA;Role;Shapes;Site;Social Distance;Source;spatiotemporal;Specific qualifier value;stem;Structure;System;Techniques;Testing;Transcriptional Activation;Transcriptional Regulation;Visualization;Work

PROJECT_TITLE: The Biophysical and Molecular Mechanisms of Reliability in Development

STUDY_SECTION_NAME: Development - 2 Study Section[DEV2]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Hematology;Immunotherapy;Infectious Diseases;Precision Medicine;Sepsis

ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: NARRATIVE Prolonged hospitalization, secondary infections, sepsis recidivism and hospital readmission are the most common long-term consequences in sepsis survivors, but we have only limited means to diagnose the immunosuppressed endotype. Here we propose to validate an ELISpot assay as an optimal biomarker to early diagnose immunosuppression, and to ex vivo test potential immune stimulants for subsequent clinical development.

PI_NAMEs: MAILE, ROBERT  (contact)

PROGRAM_OFFICER_NAME: ZHAO, XIAOLI

PROJECT_TERMS: adaptive immunity;Age;aging population;Animal Model;anti-PD-1;Antibiotics;Biological Assay;Biological Markers;Blood;Blood specimen;CD14 gene;Cell Physiology;Cells;Chronic;Clinical;clinical development;Clinical Trials;Communicable Diseases;comorbidity;comparative efficacy;Critical Illness;Data;Defect;design;Development;Diagnosis;Early Diagnosis;Effectiveness;efficacy evaluation;Enrollment;Ethnic Origin;Exclusion Criteria;Failure;Functional disorder;Future;Genomics;Goals;Granulocyte-Macrophage Colony-Stimulating Factor;HLA-DR Antigens;hospital care;Hospital Mortality;hospital readmission;Hospitalization;Hour;IL7 gene;Immune;immune function;Immune response;immune stimulant;Immunity;Immunocompetence;Immunocompromised Host;Immunologic Adjuvants;immunological status;Immunology procedure;Immunophenotyping;immunosuppressed;Immunosuppression;Immunotherapy;Impairment;improved;in vivo;Incidence;Incubated;indexing;Individual;individual patient;Infection;Inpatients;Institution;Interferon Type II;Interferons;Interleukin-6;Invaded;Knowledge;Laboratories;Length of Stay;Life;Lymphocyte Count;Measurement;Measures;Monoclonal Antibodies;monocyte;Mononuclear;mortality;Natural Immunity;Nosocomial Infections;novel;Nucleic Acids;Oncology;Organ;Outcome;pathogen;Pathogenicity;patient stratification;Patients;Phenotype;Plasma;Plasma Proteins;predictive modeling;Production;prospective;Proteins;Proteomics;Quality Control;Race;Randomized;randomized, clinical trials;recidivism;Recurrence;recurrent infection;response;Sampling;secondary infection;secondary outcome;Sepsis;septic patients;Severities;sex;Surrogate Markers;Survivors;T-Lymphocyte;tertiary care;Testing;Therapeutic;Time;TNFSF4 gene;transcriptomics;treatment response;tumor;Validation;Whole Blood

PROJECT_TITLE: Stratifying Patient Immune Endotypes in Sepsis (SPIES Study)

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


ADMINISTERING_IC: DK

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE Immune checkpoint inhibitors are a power new form of cancer treatment, but their benefits are limited by the development of autoimmune side effects in many patients. Thyroid disease is one of the most common of these autoimmune toxicities and has both overlapping and distinct features from other forms of thyroid autoimmune disease (e.g. Hashimoto’s thyroiditis). Our project will investigate the cause of these autoimmune toxicities using a mouse model and studies in patients with thyroid disease to advance our understanding of causes of thyroid autoimmunity and so that therapies may be developed.

PI_NAMEs: LECHNER, MELISSA G (contact)

PROGRAM_OFFICER_NAME: SPAIN, LISA M

PROJECT_TERMS: Acceleration;Advanced Malignant Neoplasm;anti-cancer;Antibodies;Antigen Targeting;Antigens;antitumor effect;Autoantibodies;Autoantigens;Autoimmune;Autoimmune Diseases;autoimmune pathogenesis;autoimmune thyroid disease;autoimmune toxicity;Autoimmunity;autoimmunity checkpoint;Automobile Driving;Award;B-Lymphocytes;Bioinformatics;Bladder;BLR1 gene;Breast;California;cancer immunotherapy;Cancer Patient;cancer therapy;career development;CD8B1 gene;Cells;Cessation of life;checkpoint inhibition;checkpoint therapy;Clinical;clinical care;Colon;CTLA4 gene;cytokine;Data;design;Development;Development Plans;Doctor of Medicine;Doctor of Philosophy;Eligibility Determination;Endocrine;Endocrinology;Evaluation;experience;Faculty;Fine needle aspiration biopsy;Fine-needle biopsy;Functional disorder;genetic regulatory protein;Gland;Hashimoto Disease;Head and neck structure;Hospitalization;Human;Immune;immune activation;immune cell infiltrate;Immune checkpoint inhibitor;Immune response;Immune system;immune-related adverse events;Immunotherapy;improved;improved outcome;Infiltration;inhibitor;interleukin-21;Interruption;Iodide Peroxidase;Kidney;Liver;Los Angeles;Lung;Lymphocytic Infiltrate;Malignant Neoplasms;Mediating;Medicine;Mentors;Modeling;mouse model;Mus;neoplastic cell;next generation;novel;Organ;Pathogenicity;Pathway interactions;Patients;Peripheral;Phage Display;Physicians;Population;Postdoctoral Fellow;prevent;Production;professor;programmed cell death protein 1;Proteins;Proteomics;Reporting;Research;Research Personnel;response;Role;Sampling;Scientist;side effect;skills;Students;T cell infiltration;T cell response;T-Lymphocyte;Techniques;Testing;Thyroglobulin;Thyroid Diseases;Thyroid Gland;Thyroiditis;Tissues;Toxic effect;Training;transcriptomics;Universities;Work

PROJECT_TITLE: Mechanisms of Thyroid Autoimmunity in Checkpoint Immunotherapy

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


ADMINISTERING_IC: AR

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: IRVINE

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: PROJECT NARRATIVE The overall objective of this proposal is to advance “chondrogel,” an allogeneic, cell-based filler that is essentially liquid cartilage, for gouge and focal cartilage defects as administered through an arthroscopic approach. Each year, an estimated 750,000 Americans undergo arthroscopy, and, although gouge and focal defects are frequently observed, no efficacious arthroscopic treatment exists. Chondrogel would address this pressing need especially given that, if left untreated, cartilage lesions typically worsen over time.

PI_NAMEs: ATHANASIOU, KYRIACOS A (contact);HU, JERRY C.;WANG, DEAN

PROGRAM_OFFICER_NAME: MARQUITZ, ARON

PROJECT_TITLE: Liquid cartilage for arthroscopy

STUDY_SECTION: MTE

STUDY_SECTION_NAME: Musculoskeletal Tissue Engineering Study Section[MTE]


ED_INST_TYPE: OVERALL MEDICAL

NIH_SPENDING_CATS: Behavioral and Social Science;Biotechnology;HIV/AIDS;Infectious Diseases;Patient Safety;Prevention;Sexually Transmitted Infections;Women's Health Research

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE The development of a pre-exposure prophylactic reagent that potently inhibits transmitted HIV with minimal toxicity, lack of potential for drug-drug interactions, and infrequent dosing would greatly slow the HIV epidemic. Given that nearly all mucosally-transmitted HIV is CCR5 tropic, we will test the ability of a novel, extended half- life CCR5 blocking antibody formulated for maximum concentration to prevent mucosal transmission of HIV using the macaque model. Success of these studies would establish a new, user-friendly pre-exposure prophylactic weapon for the fight against HIV.

PI_NAMEs: SACHA, JONAH B. (contact)

PROGRAM_OFFICER_NAME: DEY, BARNA

PROJECT_TERMS: Adherence;Anti-Retroviral Agents;Antibodies;antiretroviral therapy;Biopsy;Blocking Antibodies;Blood;CCR5 gene;Chemistry;Clinical;Clinical Trials;Collaborations;CXCR4 gene;Data;Development;Dose;Dose Limiting;Drug Interactions;Drug Kinetics;emerging virus;emtricitabine;Epidemic;Female;fighting;Formulation;Foundations;global health;Half-Life;Health Priorities;high risk;HIV;HIV Antibodies;HIV Infections;HIV-1;Home;Homozygote;Individual;industry partner;Infection;Injectable;Injections;Length;Macaca;male;Measurement;Measures;Mediating;Modality;Modeling;Monitor;Monoclonal Antibodies;Mucous Membrane;novel;nucleoside analog;Oral;Parents;particle;Patient Compliance;Patients;Persons;Pharmaceutical Preparations;Phase;Phase III Clinical Trials;Plasma;pre-exposure prophylaxis;prevent;Preventive vaccine;PRO 140;prophylactic;Reagent;receptor;Recording of previous events;rectal HIV transmission;rectal transmission;Rectum;Regimen;Resistance;Reverse Transcriptase Inhibitors;Safety;Schedule;Self Administration;Serum;sexual HIV transmission;Sexual Transmission;side effect;simian human immunodeficiency virus;Site;Solid;subcutaneous;success;Techniques;Tenofovir;Testing;Therapeutic;Time;Tissues;Toxic effect;transmission process;user-friendly;Vaccines;Vagina;Vaginal Ring;vaginal transmission;Variant;viral resistance;viral transmission;Virus;weapons

PROJECT_TITLE: A Solid-Phase, Long-Acting CCR5 Monoclonal Antibody for HIV Transmission


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Genetics;Infectious Diseases;Microbiome

ORG_DEPT: DENTISTRY

PHR: Project Narrative Porphyromonas gingivalis is a major periodontal pathogen that utilizes a large variety of mechanism to produce disease. The goal of this project is to understand the role of CRISPR-Cas proteins in P. gingivalis virulence. These proteins are usually associated with viral defense but we have indications that in the case of P. gingivalis they play an important role in progression of periodontal disease.

PI_NAMEs: FRIAS-LOPEZ, JORGE  (contact);GIBSON, FRANK C

PROGRAM_OFFICER_NAME: MCNEALY, TAMARA L

PROJECT_TERMS: Abscess;Address;Adult;Anabolism;Animal Model;Bacteria;Bacteriophages;BCAR1 gene;bone loss;Cell Line;Cells;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Cobalamin;Complex;Data;Development;Disease;Disease Progression;DNA;DNA Repair;Epithelial Cells;experimental study;Francisella;Gene Expression;gene function;Genes;Genetic;Gingiva;Goals;Health;Health Transition;Human;human microbiota;IL8 gene;Immune;Immune response;Immunity;in vivo;infancy;Infection;Inflammation;Inflammatory;Innate Immune Response;Interleukin-1 beta;Iron;keratinocyte;Knowledge;Libraries;Macrophage;Measures;Metabolism;metatranscriptome;microbial;microbial community;Modeling;Molecular;Moths;Mus;mutant;neutrophil;novel;Operon;Oral;oral infection;Outcome;pathogen;Pathogenicity;Periodontal Diseases;Periodontitis;periodontopathogen;Play;polymicrobial disease;Porphyromonas gingivalis;prevent;Production;programs;Proteins;Proteolysis;Pseudomonas aeruginosa;Publishing;Qualifying;remediation;Reporting;Research;Role;Sampling;Signal Transduction;Site;System;Testing;Therapeutic;Tissues;TLR2 gene;TLR4 gene;TNF gene;Toll-like receptors;Tooth structure;transcriptome;Viral;Virulence;Virulence Factors;Waxes;Work

PROJECT_TITLE: A novel mechanism of virulence control in Porphyromonas gingivalis


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Cancer;Climate-Related Exposures and Conditions;Natural Products;Prevention;Skin Cancer;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: AUSTIN

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

ORG_STATE: TX

PHR: PROJECT NARRATIVE Nonmelanoma skin cancer is the most common cancer and consists of basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). Although BCC is more common, SCC metastases account for up to 20% of all deaths from skin cancer. The proposed studies will further elucidate the role of Twist1 in development of cutaneous SCC, especially in the early stages of skin tumor development and validate Twist1 as a target for the prevention and treatment of cSCC.

PI_NAMEs: DIGIOVANNI, JOHN  (contact)

PROGRAM_OFFICER_NAME: JOHNSON, RONALD L

PROJECT_TERMS: Alkaloids;Applications Grants;Automobile Driving;Basal cell carcinoma;Biological Models;Carcinoma;cell behavior;Cell Culture Techniques;Cell Cycle Proteins;Cell Differentiation process;Cessation of life;Clinic;Data;design;Development;Differentiation Antigens;Disease;Epidermis;Epithelium;Equilibrium;experimental study;Exposure to;G1 Phase;Genes;Genetic;Goals;Harmine;Immunofluorescence Immunologic;in vivo;in vivo Model;Incidence;inhibitor;keratinocyte;keratinocyte differentiation;knock-down;Knockout Mice;Laboratories;LoxP-flanked allele;Malignant Epithelial Cell;Malignant Neoplasms;Mesenchymal;Messenger RNA;migration;Modeling;mouse model;Mus;Natural Compound;Neoplasm Metastasis;novel;novel strategies;overexpression;Play;prevent;Prevention;Prevention approach;Process;Proliferating;Proliferation Marker;Proteins;Protocols documentation;Regulation;Reporting;Research;response;Role;S phase;Skin Cancer;Skin Carcinogenesis;Skin Carcinoma;Skin Neoplasms;skin squamous cell carcinoma;Squamous cell carcinoma;stem cell differentiation;stem cell homeostasis;stem cell proliferation;stem cells;stemness;Study Section;Testing;TP53 gene;transcription factor;Transgenic Mice;Translations;tumor;tumor progression;Tumor Promotion;Ultraviolet B Radiation;UV induced

PROJECT_TITLE: Twist1 as a Target for Prevention and Treatment of Cutaneous Squamous Cell Carcinoma

STUDY_SECTION: CPSS

STUDY_SECTION_NAME: Cancer Prevention Study Section[CPSS]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Antimicrobial Resistance;Emerging Infectious Diseases;Infectious Diseases;Microbiome

ORG_CITY: ATHENS

ORG_NAME: UNIVERSITY OF GEORGIA

PHR: Project Narrative We endeavor to discern the mechanistic details of how microbes act in concert with each other to resist antimicrobial compounds in nature and in the context of infection. This will enhance our basic understanding of microbial community structures, and give greater biological context to mechanisms of antimicrobial resistance. This knowledge has the potential to increase our ability to reduce treatment failure of antimicrobial drugs.

PI_NAMEs: DAHLSTROM, KURT M. (contact)

PROGRAM_OFFICER_NAME: BOND, MICHELLE RUEFFER

PROJECT_TERMS: Animals;anti-fungal agents;anti-microbial drug;antimicrobial;Antimicrobial Resistance;Aspergillus;Bacteria;Biological;Biological Models;Clinical;Communication;Communities;Drug Metabolic Detoxication;Drug usage;Environment;Exclusion;fungus;Health;host-associated microbial communities;Human;Infection;interest;Knowledge;Mediating;member;Microbe;microbial community;microbial composition;microorganism interaction;Names;natural antimicrobial;Nature;novel;Organism;pathogenic fungus;Pharmaceutical Preparations;Plants;Play;Porifera;Process;Resistance;resistance mechanism;response;Sampling;Shapes;Signal Transduction;Stress;Structure;Symbiosis;Toxin;Treatment Failure;Work

PROJECT_TITLE: Bacterial partners as a mode of fungal resistance to antimicrobial compounds

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MGG-J(55)R]


ORG_DEPT: NEUROLOGY

PHR: Project Narrative Brain edema refers to the biologic response that occurs in most patients who suffer strokes and other brain injuries, leading to swelling of brain tissue, deterioration and even death. There are currently no effective therapies to prevent or even adequately treat brain edema after a stroke. In this project, we will combine genetic information on a large cohort of stroke patients with imaging analyses that quantify the severity of swelling to understand the key mediators and pathways contributing to edema.

PI_NAMEs: DHAR, RAJAT  (contact)

PROGRAM_OFFICER_NAME: BOSETTI, FRANCESCA

PROJECT_TERMS: Acute;acute stroke;Age;analysis pipeline;annotation  system;Attenuated;automated analysis;automated image analysis;bioinformatics tool;Biological;Biological Factors;Biological Markers;Biology;Blood Pressure;blood-brain barrier permeabilization;Brain Edema;Brain hemorrhage;Brain Injuries;brain tissue;brain volume;Cerebral Edema;Cerebrospinal Fluid;Cerebrum;Cessation of life;Clinical;cohort;Data;Data Set;Databases;density;Deterioration;Development;Dimensions;Disparate;drug discovery;Edema;effective therapy;empowerment;Enrollment;Exhibits;follow-up;Funding;gene discovery;Genes;Genetic;genetic architecture;genetic information;Genetic study;genetic variant;genome wide association study;genomic data;Genomics;Genotype;Glucose;Goals;Growth;Hemorrhage;Heritability;Heterogeneity;Hospitals;Human;Hyperglycemia;Hypertension;Image;imaging genetics;Impairment;improved outcome;Infarction;injured;Injury;insight;interpatient variability;Intervention;Intracranial Pressure;Ion Channel;Ischemia;Ischemic Stroke;Knowledge;Link;Malignant - descriptor;Measurement;Measures;Mediating;Mediator;Mendelian randomization;Microvascular Dysfunction;Modeling;Molecular;Molecular Target;National Institute of Neurological Disorders and Stroke;Neurologic;Neurons;novel;Outcome;Participant;Pathologic;Pathway interactions;patient variability;Patients;Phenotype;Population;post stroke;prevent;Quantitative Genetics;quantitative imaging;Recovery;Renal function;Reperfusion Therapy;repository;response;Risk;Sample Size;Severities;sex;Source;Stroke;stroke outcome;stroke patient;stroke recovery;success;Swelling;targeted treatment;Time;Tissues;trait;Trauma;Traumatic Brain Injury;tumor;uptake;Water;white matter injury;Work;X-Ray Computed Tomography

PROJECT_TITLE: Genetic Architecture of Cerebral Edema after Stroke

STUDY_SECTION: NAME

STUDY_SECTION_NAME: Neurological, Aging and Musculoskeletal Epidemiology Study Section[NAME]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Genetics

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE This project will advance understanding of the biological mechanisms contributing to cellular senescence, a known driver of aging and disease. Specifically, it will allow the investigation of mitochondrial apoptotic stress as a driver of senescence and test the efficacy of interventions inhibiting this process during aging. This knowledge could potentially lead to novel clinical treatments to counteract aging and age-related disease.

PI_NAMEs: PASSOS, JOAO  (contact)

PROGRAM_OFFICER_NAME: OROSZ, ANDRAS

PROJECT_TERMS: age related;Age related pathologies;age-related disease;Aging;aging related;Apoptosis;Apoptosis Regulation Gene;Apoptotic;BAX gene;Bax protein;Biological;Caspase;CDKN2A gene;Cell Aging;Cell Cycle Arrest;Cell Death Induction;Cell Membrane Permeability;Chronic;Clinical Treatment;cytochrome c;Cytosol;Data;Disease;DNA Damage;drivers of aging;drug development;Drug Targeting;effectiveness testing;efficacy testing;Excision;experimental study;Functional disorder;Genetic;Goals;healthspan;healthy aging;improved;In Vitro;in vitro activity;in vivo;Inflammatory;innovation;interest;Intervention;Investigation;Kinetics;Knowledge;Link;live cell imaging;Mediating;Mediator;Minority;Mitochondria;Mitochondrial DNA;mitochondrial dysfunction;Molecular;Morphology;mouse model;Mus;new therapeutic target;novel;novel therapeutics;Outer Mitochondrial Membrane;Pathway interactions;Pharmaceutical Preparations;pharmacologic;Phenotype;Population;preservation;pro-apoptotic protein;Process;Reporter;response;Role;senescence;senescence associated secretory phenotype;senescent cell;Stimulator of Interferon Genes;Stress;superresolution microscopy;System;tissue degeneration;Tissues;tool;Treatment Efficacy;Tumor Suppressor Proteins;Visualization;Work

PROJECT_TITLE: The role of sub-lethal mitochondrial apoptotic stress in cellular senescence

STUDY_SECTION: CMAD

STUDY_SECTION_NAME: Cellular Mechanisms in Aging and Development Study Section[CMAD]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Microbiome;Networking and Information Technology R&D (NITRD)

ORG_CITY: MADISON

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Project Narrative/Public Health Relevance This study presents new computational approaches, significant improvements to existing approaches, and applications to study bacteriophage diversity, genomics, ecology, and dynamics from metagenome sequences. We will establish open access databases and software, and demonstrate the validity of our methods on clinically relevant metagenomics data.

PI_NAMEs: ANANTHARAMAN, KARTHIK  (contact)

PROGRAM_OFFICER_NAME: KEANE-MYERS, ANDREA

PROJECT_TITLE: COMPUTATIONAL FRAMEWORKS FOR PHAGE DISCOVERY, ECOLOGY, AND DYNAMICS FROM METAGENOMES


ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Narrative One crucial step in the cell division cycle is the complete and precise replication of chromosomal DNA, and errors in DNA replication control can cause developmental abnormalities, tissue degeneration (aging), cell death, or cancer. We will address pressing unanswered questions about how the earliest irreversible step in DNA replication is normally controlled. The knowledge gained from this work will inform future diagnostics and precision therapies in both regenerative medicine and cancer treatment.

PI_NAMEs: COOK, JEANETTE GOWEN (contact)

PROGRAM_OFFICER_NAME: MACARTHUR, LINDA

PROJECT_TERMS: Aging;Architecture;Biochemistry;cancer therapy;Cell Cycle;Cell Cycle Regulation;Cell Death;Cell Proliferation;Cells;Chromatin;Companions;Competence;Complex;Defect;Development;Diagnosis;Diagnostic;DNA;DNA biosynthesis;DNA Repair;DNA replication fork;DNA replication origin;Ensure;Environment;Event;extracellular;Future;G1 Phase;Genome;Genomic Instability;genomic locus;Goals;helicase;Human;innovation;insight;Knowledge;Length;Licensing;Maintenance;Malignant Neoplasms;Mammalian Cell;mammalian genome;Molecular;molecular dynamics;Molecular Genetics;Oncogene Activation;Outcome;Pathology;Pathway interactions;Precision therapeutics;programs;Proliferating;Regenerative Medicine;Regulation;Replication Initiation;Research;S phase;single cell analysis;Stream;success;Testing;tissue degeneration;tool;tumorigenesis;Work

PROJECT_TITLE: Cell Cycle Dynamics that Ensure Genome Maintenance

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-D(55)R]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Kidney Disease;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Dialysis is the main treatment for end-stage kidney disease, which has poor outcomes and disproportionately affects underserved minorities. Although disparities in the quality of dialysis care are well-known, researchers and healthcare providers have a poor understanding of why these disparities occur. This project will identify the mechanisms that contribute to racial and ethnic differences in dialysis outcomes and will test the potential impact of future interventions aimed at addressing these disparities.

PI_NAMEs: LIN, EUGENE  (contact)

PROGRAM_OFFICER_NAME: NORTON, JENNIFER MICHELLE

PROJECT_TERMS: Address;Affect;Alaska Native;American Indians;Area;Black Populations;Black race;Breast;Caring;Chronic Disease;Colorectal;Conceptions;County;Death Rate;design;Dialysis procedure;Disparity;disparity reduction;End stage renal failure;Equity;ethnic difference;ethnic disparity;ethnic health disparity;ethnic minority;Ethnic Origin;Evaluation;Fee-for-Service Plans;financial incentive;Future;Goals;health care disparity;health disparity;Health Personnel;Health Service Area;Home;Hospital Referrals;hospital services;Hospitalization;improved;improved outcome;Individual;innovation;Intervention;Intervention Studies;Joints;Kidney;Kidney Transplantation;Knowledge;Latino;Link;Literature;Malignant neoplasm of prostate;Malignant Neoplasms;Marketing;Measures;Medicare;Medicare claim;Methods;Modality;Morbidity - disease rate;Myocardial Infarction;Native Hawaiian or Other Pacific Islander;Neighborhoods;Outcome;Patients;payment;Policies;Policy Maker;Provider;Publishing;Quality of Care;Quasi-experiment;Race;racial difference;racial disparity;racial minority;Registries;Research;Research Personnel;research study;Resources;safety net;Selection Bias;stem;Testing;therapy design;underserved area;underserved minority;Work

PROJECT_TITLE: Elucidating the Mechanisms of Racial and Ethnic Disparities in Dialysis Quality

STUDY_SECTION: HSQE

STUDY_SECTION_NAME: Health Services: Quality and Effectiveness Study Section[HSQE]


NIH_SPENDING_CATS: Neurodegenerative;Rare Diseases

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE Mitochondria are organelles at the nexus of cell functions (energy production, calcium signaling, metabolism and programmed cell death) central to cancer, cardiac health and neurodegeneration. The interplay between protein structure and membrane shape is fundamental for understanding the principles of organelle morphology that lie at the heart of mitochondrial function. We will explore questions of protein structure, membrane environment and sub-cellular ultrastructure to develop an integrated program that explores central questions of organelle shape.

PI_NAMEs: CHAO, LUKE H. (contact)

PROJECT_TERMS: Apoptosis;Autosomal Dominant Optic Atrophy;Beds;Biophysical Process;biophysical techniques;Calcium Signaling;Cardiac;Cardiac health;Cell Physiology;Cells;Complex;computational pipelines;Computer Analysis;Crista ampullaris;Cryo-electron tomography;Cryoelectron Microscopy;Dependence;Disease;early onset;Elements;Encephalopathies;Environment;Family;Foundations;Goals;Heart Mitochondria;Heterogeneity;Homeostasis;In Vitro;Inner mitochondrial membrane;interest;Knowledge;Leigh Disease;Lipids;Liposomes;Liver diseases;Malignant Neoplasms;member;Membrane;Membrane Proteins;membrane reconstitution;Metabolic;Metabolism;Mitochondria;mitochondrial membrane;Modeling;Molecular Conformation;Morphology;Mutate;Nature;Nerve Degeneration;Nervous System Disorder;OPA1 gene;Organelles;particle;Physiological;Physiology;Play;Production;programs;Property;protein complex;Protein Conformation;protein protein interaction;protein structure;Proteins;reconstitution;Regulation;Resolution;Role;Shapes;solute;Structure;System;targeted treatment;Testing;therapeutic development;Tissues;tool;Visualization

PROJECT_TITLE: Probing structural and biophysical mechanisms of mitochondrial membrane ultrastructure

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-V(55)R]


NIH_SPENDING_CATS: Neurosciences

ORG_CITY: PITTSBURGH

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROGRAM NARRATIVE Basic research focused on the interface between behavior and the brain is crucial for understanding the mechanisms and treatment of a large number of human health issues. The Behavioral Brain (B2) Research Training Program trains predoctoral behavioral science students to incorporate neuroscience perspectives and methods into their programs of research, and imparts the skills needed for biomedical careers in the academic, government, nonprofit, and private sectors.

PI_NAMEs: FIEZ, JULIE A (contact);SMITH, MATTHEW A

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - A[TWD-A]


ORG_CITY: LA JOLLA

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

PHR: Relevance This proposal centers on the development of novel chiral catalysts and new approaches to achieve the enantioselective sp3 C–H activation of readily-available carboxylic acids, ketones and amines. These reactions will provide new strategies for constructing -, - and -stereocenters; broadly useful in asymmetric syntheses of chiral bioactive compounds and drug molecules. In a collaborative effort, these new synthetic technologies will be applied to the discovery of promising new drug candidates for the treatment of human diseases.

PI_NAMEs: YU, JIN-QUAN  (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TERMS: Acceleration;Acetates;Acids;activity-based protein profiling;Acute respiratory failure;Address;Aldehydes;Amides;Amines;Attenuated;Binding;carbene;Carbon;Carboxylic Acids;catalyst;chelation;Collaborations;Coupling;covalent bond;Cysteine;design;Development;Distal;drug candidate;drug discovery;Drug Industry;human disease;Hydrogen Bonding;inhibitor;Ketones;Laboratories;Lactams;Lactones;Ligand Binding;Ligands;Mediating;Metals;Methods;neutrophil elastase inhibitor;novel;novel strategies;novel therapeutics;Organic Synthesis;Oxidants;Pharmaceutical Preparations;Preparation;programs;Proteins;Pyridones;quinoline;Reaction;recruit;Research;scaffold;Serine Hydrolase;Silver;Source;success;tautomer;Technology;tert-Butylhydroperoxide;thioether

PROJECT_TITLE: Ligand-Promoted Enantioselective C-H Activation Reaction

STUDY_SECTION: SBCB

STUDY_SECTION_NAME: Synthetic and Biological Chemistry B Study Section[SBCB]


ADMINISTERING_IC: TR

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Digestive Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: Durham

ORG_NAME: ALTIS BIOSYSTEMS, INC.

PHR: Project Narrative  Screening candidate therapeutics for potential adverse side effects is a key component of most preclinical studies prior to clinical testing of new drugs. However, assays using tumor-derived/transformed cell lines or small animals to test toxic effects against the gastrointestinal (GI) system are largely ineffective at predicting diarrhea, inflammation, or other adverse events. Altis Biosystems, Inc. has developed a novel platform called RepliGut® StemScreen, which allows evaluation of drugs applied to primary proliferative stem/progenitor cell populations isolated from normal GI tissues. In vivo, the stem/progenitor cells are responsible for repair and replenishment of epithelia during exposure to toxic agents or damage, but these regenerative cell types are not offered by any commercially available screening assay or platform. Enabling rapid, cost-effective, and early-stage screening of intestinal and colonic stem/progenitor cells will allow drug manufacturers to re-engineer or re-formulate therapeutics at earlier stages of development to mitigate the risk of off-target GI side effects and de-risk later stage clinical trials in humans.

PI_NAMEs: SIMS, CHRISTOPHER ELDRIDGE (contact)

PROGRAM_OFFICER_NAME: RUDNICKI, DOBRILA DODA

PROJECT_TERMS: 3-Dimensional;Address;Adopted;Adverse event;adverse event risk;Age;Animal Model;Animals;Apical;Area;Benchmarking;Biological Assay;Biological Models;Body mass index;Caco-2 Cells;Cell Differentiation process;Cell model;Cell Physiology;Cell Survival;cell type;Cells;Cellular Structures;Cessation of life;Clinical;Clinical Data;clinical translation;Clinical Trials;clinically relevant;Colon;commercial launch;Competence;Complement;cost effective;Culture Media;Data;Data Analyses;Data Set;demographics;detection assay;Development;Diarrhea;Disease;Dose;Dose Limiting;Drug Evaluation;Drug Exposure;Drug Kinetics;drug mechanism;Drug Screening;Drug Targeting;Engineering;Epithelium;ethnic diversity;Excision;experimental study;Exposure to;Fee-for-Service Plans;Feedback;Female;gastrointestinal;gastrointestinal epithelium;gastrointestinal system;Gastrointestinal tract structure;Goals;Human;Image;Impairment;improved;In Vitro;in vitro Model;in vivo;Industry;Inflammation;interest;intestinal barrier;intestinal epithelium;Intestines;jejunum;kinase inhibitor;lead optimization;Life Cycle Stages;male;Manufacturer;Marketing;Measures;meter;Microinjections;Modeling;monolayer;novel;novel therapeutics;Oncology;Organoids;Outcome;Pharmaceutical Preparations;Pharmacologic Substance;Phase;phase 1 study;phase 2 study;phase III trial;Physiology;Plasma;Population;preclinical safety;preclinical study;Proliferating;Property;Protocols documentation;Publishing;Rattus;regenerative cell;repaired;research clinical testing;Rho-associated kinase;Risk;risk mitigation;Running;Safety;screening;screening services;self-renewal;side effect;Small Intestines;Source;stem;stem cell population;stem cell proliferation;stem cells;success;Technology;Testing;Therapeutic;therapeutic candidate;Therapeutic Effect;timeline;Tissue Donors;Tissues;Toxic effect;Toxicology;Transformed Cell Line;Transverse colon;Tumor Cell Line;Tumor-Derived;Ulcer;Validation;Work

PROJECT_TITLE: Planar culture of gastrointestinal stem cells for screening pharmaceuticals for adverse event risk


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences;Nutrition;Obesity;Prevention

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: PROJECT NARRATIVE Consumption of foods high in sugar, salt, and fat is one of the underlying causes of obesity, a condition that affects more than 40% of Americans, promotes chronic disease, and lowers life expectancy. This dietary environment increases meal size and food intake to drive weight gain, but a mechanistic understanding of how this occurs is still elusive: the proposed experiments will use the fly model to address this question. Because the neurochemistry involved in meal size is conserved, these discoveries will advance our understanding of the role of the dietary environment in promoting obesity in ways that are directly related and translatable to mammals.

PI_NAMEs: AKAABOUNE, MOHAMMED ;DUS, MONICA  (contact)

PROGRAM_OFFICER_NAME: COOKE, BRAD

PROJECT_TERMS: Address;Affect;American;Animal Feed;Animals;Appetitive Behavior;Association Learning;Behavior;Behavioral Assay;Body Weight;Brain;Brain region;Calcium;Calories;Chronic Disease;connectome;Consumption;Cues;Data;density;Development;Diet;dietary;Dopamine;dopaminergic neuron;Eating;Environment;Etiology;expectation;experience;experimental study;Exposure to;Fatty acid glycerol esters;Feeding behaviors;fly;Food;food consumption;food environment;food quality;Functional Imaging;Future;Genetic;Goals;high body mass index;Human;Impairment;in vivo calcium imaging;in vivo imaging;Intake;Invertebrates;Knowledge;Learning;learning network;Life Expectancy;Link;Mammals;Measurement;Memory;Metabolic;Metabolic Diseases;Metabolic syndrome;Mission;Modeling;Motor;Mushroom Bodies;National Institute of Diabetes and Digestive and Kidney Diseases;neural;neural circuit;neurochemistry;neurogenetics;neuromechanism;Neurons;neuroregulation;neurotransmission;Nutrient;Obesity;obesogenic;optogenetics;Output;Play;prevent;Process;Property;Psychological reinforcement;Publishing;recruit;Research;Rewards;Role;sensor;Sensory;Signal Transduction;Sodium Chloride;sugar;System;Taste Perception;Testing;tool;Transgenic Organisms;transmission process;Vertebrates;Visualization;Weight Gain;Work

PROJECT_TITLE: Neural determinants on meal size in invertebrate models of obesity

STUDY_SECTION: BNRS

STUDY_SECTION_NAME: Behavioral Neuroendocrinology, Neuroimmunology, Rhythms, and Sleep Study Section [BNRS]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Brain Cancer;Brain Disorders;Cancer;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: SAINT LOUIS

ORG_DEPT: NEUROSURGERY

ORG_NAME: WASHINGTON UNIVERSITY

PHR: PROJECT NARRATIVE The proposed research is relevant for public health because it will develop a novel brain drug delivery technique for improving the treatment of brain diseases, which are major public health problems in the United States. This technique can achieve noninvasive, spatially targeted, and efficient drug delivery to diseased brain sites without jeopardizing healthy brain regions and other organs. This technique holds great promise to radically advance the treatment of a broad spectrum of brain diseases.

PI_NAMEs: CHEN, HONG  (contact)

PROGRAM_OFFICER_NAME: KING, RANDY LEE

PROJECT_TERMS: Address;animal data;Animal Disease Models;Animal Model;Animals;anti-PD-L1;anti-PD-L1 antibodies;Biodistribution;Biophysical Process;Blood - brain barrier anatomy;Blood Vessels;blood-brain barrier disruption;Brain;Brain Diseases;Brain Neoplasms;Brain region;brain tissue;Bypass;Cancer Biology;Central Nervous System Diseases;Cephalic;Clinic;Clinical;clinical translation;Clinical Trials;Convection;Data;Dependence;Detection;Devices;Disease;disease model;Dose;Drug Delivery Systems;Drug Transport;Engineering;Exposure to;extracellular;Family suidae;Focused Ultrasound;Funding;Future;Glioblastoma;glymphatic system;Goals;Immune checkpoint inhibitor;Implant;improved;in vivo;innovation;insight;Intranasal Administration;Intravenous;intravenous injection;Knowledge;Location;Mediating;Microbubbles;microscopic imaging;Modeling;Monitor;mouse model;multidisciplinary;Mus;National Institute of Biomedical Imaging and Bioengineering;neoplastic cell;neuro-oncology;neuroinflammation;Neuronavigation;Nose;novel;Operative Surgical Procedures;optimal treatments;Organ;Outcome;Patient-Focused Outcomes;Patients;Penetration;Pharmaceutical Preparations;Phase;Positioning Attribute;Positron-Emission Tomography;pre-clinical;pressure;Public Health;Radiochemistry;Radiolabeled;Radiology Specialty;Research;Route;Safety;safety assessment;scale up;side effect;Site;Sonication;success;systemic toxicity;targeted delivery;Techniques;technology platform;Testing;Therapeutic;Therapeutic Agents;Time;Tissues;Translating;translational potential;Transportation;Treatment outcome;two photon microscopy;ultrasound;United States;United States National Institutes of Health

PROJECT_TITLE: Focused ultrasound-mediated intranasal brain drug delivery technique (FUSIN)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ISB-J(03)M]


PHR: PROJECT NARRATIVE The pathogenic fungus Cryptococcus neoformans causes a meningoencephalitis that kills almost 200,000 peo- ple per year. Striking differences in virulence are observed among naturally occurring strains of this microbe. The goal of this research is to identify the regions of the genome, and specific changes in DNA sequence, that are responsible for these differences. Successful completion of these studies will establish powerful new meth- ods and significant community resources for research, increase fundamental understanding of this organism and the disease it causes, and potentially impact antifungal drug development.

PI_NAMEs: DOERING, TAMARA L (contact)

PROGRAM_OFFICER_NAME: LOVE, DONA

PROJECT_TERMS: Alleles;anti-fungal agents;Antifungal Therapy;Applied Genetics;Biological;Biology;Candidate Disease Gene;Cessation of life;Clinical;Collection;Communities;comorbidity;Cryptococcal Meningitis;Cryptococcosis;Cryptococcus;Cryptococcus neoformans;Cryptococcus neoformans infection;Dangerousness;Data;Data Set;Disease;Disease Outcome;Disease Progression;DNA Sequence;drug development;Drug Targeting;Engineering;Environment;Evolution;falls;fascinate;follow-up;Fungal Genes;fungus;Future;Gene Expression;Genes;Genetic;genetic analysis;genetic variant;Genome;Genome engineering;Genomic Segment;Genomics;Goals;Growth;HIV;In Vitro;Individual;innovation;interest;Investigation;Laboratories;Laboratory culture;Lung;Measures;Meningoencephalitis;Methods;Microbe;Molecular;Morbidity - disease rate;mouse model;Mus;mutant;offspring;Organism;Outcome;Parents;pathogen;Pathogenesis;pathogenic fungus;pathogenic microbe;Pathogenicity;patient population;Patients;Persons;Phenotype;Physiology;Population;Process;Production;Reagent;Recombinants;Records;Research;Research Personnel;resilience;Resolution;Resources;Severity of illness;Stress;Structure;Surveys;therapeutic biomarker;therapeutic target;Validation;Variant;Virulence;Virulence Factors

PROJECT_TITLE: Natural genomic variants that influence cryptococcal pathogenicity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDM-M(02)]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Genetic Testing;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Human Genome;Networking and Information Technology R&D (NITRD);Patient Safety;Rare Diseases;Social Determinants of Health

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PROJECT NARRATIVE Hundreds of millions of individuals suffer from rare genetic diseases and despite improvements in genetic testing technology and awareness many suffer years of diagnostic odyssey before getting a diagnosis if they get one at all. Increased use of electronic health records (EHR) have provided an opportunity to translate the current knowledge of genetics diseases into real world clinical care to add to the understanding of disease presentation and build tools to identify undiagnosed patients. Here, we leverage a previously curated EHR- based database of genetic testing and diagnosis and both knowledge-driven and data driven tools to identify undiagnosed patients to 1) provide a resource translating and extending current clinical descriptions of genetic diseases to the EHR, 2) assess the diagnostic yield from EHR tools to identify undiagnosed patients and 3) improve our understanding of socioeconomic, demographic, and phenotypic factors that contribute to diagnostic delay.

PI_NAMEs: BASTARACHE, LISA  (contact);RUDERFER, DOUGLAS

PROGRAM_OFFICER_NAME: CHANG, CHRISTINE Q

PROJECT_TERMS: Address;Adult;Affect;Algorithms;Awareness;Case Series;Catalogs;Characteristics;Clinical;clinical care;Clinical Data;clinical database;clinical diagnosis;Complex;cost;Data;data curation;Demographic Factors;Detection;Diagnosis;Diagnostic;Disease;Education;electronic health data;Electronic Health Record;experience;Family;Genetic;Genetic Databases;Genetic Diseases;genetic disorder diagnosis;Genetic Services;Genetic study;genetic testing;Goals;Growth;Health;health care disparity;health care service;Healthcare;improved;Individual;Informatics;Knowledge;knowledge base;Learning;machine learning algorithm;Masks;Medical Genetics;Mendelian disorder;Methods;Morbidity - disease rate;mortality;Nature;novel;novel strategies;Online Mendelian Inheritance In Man;Patients;Pattern;pediatric patients;Phenotype;portability;Provider;rare condition;Rare Diseases;rare genetic disorder;Research Personnel;Resources;Risk;Socioeconomic Factors;Socioeconomic Status;socioeconomics;Symptoms;targeted treatment;Technology;Test Result;Testing;Time;tool;Translating;Variant;Visit;Work;World Health

PROJECT_TITLE: Translating the Clinical Knowledge of Mendelian Diseases to Real-world EHR Data to Improve Identification of Undiagnosed Patients


ORG_CITY: CHICAGO

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: Project Narrative The vast majority of newly discovered small molecule pharmaceuticals from the last decade contain a heterocyclic substructure, underscoring the critical function of heterocycles in medicinal chemistry. Nonetheless, preparation of these compounds remains a challenge, slowing the pace of progress in therapeutic innovation. This research program introduces a conceptually distinct approach for access to these important compounds, preparing them from other ring systems by single-atom insertion reactions and thus enabling the more efficient preparation of new medicines.

PI_NAMEs: LEVIN, MARK DANIEL (contact)

PROJECT_TITLE: Construction of Heteroarenes Through Single Atom Insertion Strategies

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-Q(55)R]


PHR: Project Narrative Leishmania braziliensis parasites cause the disfiguring human diseases cutaneous and mucocutaneous leishmaniasis, for which the treatments are often toxic, ineffective, and are facing resistance. This proposal seeks to develop a versatile genetic tool that can be used to identify proteins that are important for parasite survival or that cause the parasites to resist drug treatments. The information gleaned from these studies could be useful in developing new drugs to treat these devastating diseases.

PI_NAMEs: YATES, PHILLIP A (contact)

PROGRAM_OFFICER_NAME: JOY, DEIRDRE A

PROJECT_TERMS: Acceleration;Bar Codes;Biology;Communities;constitutive expression;CRISPR/Cas technology;Cutaneous Leishmaniasis;Defect;Disease;DNA Library;Double-Stranded RNA;drug action;Drug resistance;Ensure;Enterobacteria phage P1 Cre recombinase;Essential Genes;fitness;Generations;Genes;Genetic;Genetic Recombination;Genetic Screening;Genetic Transcription;Genome;genome-wide;Genomic DNA;Glean;Goals;Growth;human disease;improved;Incidence;Individual;inducible Cre;inducible gene expression;innovation;insight;knock-down;Leishmania;Leishmania braziliensis;Libraries;Life Cycle Stages;loss of function;member;Messenger RNA;Methods;Miltefosine;Molecular Genetics;Mucocutaneous leishmaniasis;neglected tropical diseases;new therapeutic target;novel;novel therapeutics;Parasites;Pathology;Pathway interactions;Peptides;Persons;Pharmaceutical Preparations;Pharmacotherapy;Plasmids;Production;Proteins;recombinase;Reproducibility;Resistance;resistance gene;Resources;Ribosomal RNA;Ribosomes;RNA;RNA Interference;RNA interference screen;Sirolimus;Site;stem;System;Tertiary Protein Structure;tool;Transfection;Trypanosoma brucei brucei;Validation;vector;Viannia

PROJECT_TITLE: Generation and Validation of a Novel Genome-Scale Inducible RNAi Library for Functional Genetics in Leishmania braziliensis.


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Eye Disease and Disorders of Vision;Gene Therapy;Genetics;Hearing Loss;Neurosciences;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Usher Syndrome

ORG_CITY: CORAL GABLES

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

PHR: NARRATIVE: Gene and cell-based therapies using genome editing offer the promise of treatment for a variety of inherited disorders but has not been used successfully for human hereditary deafness including Usher syndrome. Extraordinary new tools based on CRISPR/Cas9 based exon-skipping strategies have recently been developed to treat genetic disorders. We will use these to correct mutations in three different Usher genes that cause inherited hearing loss in humans, using human inner ear cells and animal models engineered to carry these specific mutations.

PI_NAMEs: CHEN, ZHENG-YI ;LIU, XUE Z (contact)

PROGRAM_OFFICER_NAME: WATSON, BRACIE

PROJECT_TERMS: Affect;Animal Model;Auditory;autosomal recessive trait;Biological Assay;Blindness;Budgets;Cell Line;Cell model;Cell Therapy;Cells;Classification;Clinical;clinical application;clinical subtypes;Clinical Trials;Cochlear Implants;Code;Communication;Coping Skills;CRISPR/Cas technology;current pandemic;Data;deaf;Deafblind;deafness;design;Development;early childhood;Electrophysiology (science);Engineering;Excision;exon skipping;Exons;Foundations;frontier;Gene Expression Profiling;Gene Transduction Agent;Generations;Genes;genetic deafness;Genetic Diseases;genome editing;Genomic DNA;Genomics;Goals;Guide RNA;Hair;Hair Cells;Hearing;hearing restoration;Hereditary Disease;hereditary hearing loss;Human;human induced pluripotent stem cells;improved;in vivo;induced pluripotent stem cell;Inherited;Inner Hair Cells;Knockout Mice;Labyrinth;Masks;Mediating;Messenger RNA;Modeling;mouse model;Mus;mutant;Mutation;mutation correction;National Institute on Deafness and Other Communication Disorders;Nature;novel;novel therapeutic intervention;Organ of Corti;Organoids;Patients;Persons;Phenotype;pre-clinical;Prevalence;Production;protein structure;Proteins;Protocols documentation;Recovery;Research;Retina;Severities;Social Distance;stem cell organoids;Structure;Symptoms;Technology;Testing;Therapeutic;therapeutic genome editing;therapeutically effective;therapy development;Time;tool;Transgenic Organisms;treatment strategy;United States;USH1D gene;USH2A gene;Usher Syndrome;whole genome;Wild Type Mouse;Work;Zebrafish

PROJECT_TITLE: Development of CRISPR/Cas9-based exon-skipping strategies for the treatment of USH-associated deafness

STUDY_SECTION: TAG

STUDY_SECTION_NAME: Therapeutic Approaches to Genetic Diseases Study Section[TAG]


ORG_NAME: BOSTON CHILDREN'S HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Syndromic disorders and structural birth defects account for a large portion of infants and children with rare disease. Given these are very rare conditions, evidence supporting the relationship of the disease with a gene is often lacking, which can make genetic testing for these conditions challenging and imperfect. We bring together a group of experts from over 20 institutions to evaluate which genes cause syndromic disorders in order to improve medical care.

PI_NAMEs: O'DONNELL-LURIA, ANNE  (contact)

PROGRAM_OFFICER_NAME: OREILLY, JULIA JIAQI

PROJECT_TERMS: Aloral;Australia;care delivery;Caring;Case Series;Case Study;Child;Childhood;Classification;Clinical;clinical care;clinical diagnosis;clinical diagnostics;Clinical Management;clinical practice;ClinVar;Communities;Complex;congenital anomaly;Data;Dedications;Diagnostic;Diagnostic tests;Disease;disease-causing mutation;England;exome sequencing;expedited review;experience;falls;Family Planning;Funding;Genes;Genetic;genetic counselor;genetic disorder diagnosis;genetic testing;genome resource;genome sequencing;Genomics;Human Resources;improved;Infant;Infant Mortality;Institution;interest;International;knowledgebase;Laboratories;Level of Evidence;Medical;meetings;member;model organism;Molecular Diagnosis;Molecular Diagnostic Testing;Morbidity - disease rate;mortality;Nature;next generation sequencing;novel;Online Mendelian Inheritance In Man;Ontology;Organ;Pathogenicity;Pathway interactions;Pattern;Phenotype;Population;Positioning Attribute;Pregnancy;Processed Genes;Productivity;Publications;Publishing;rare condition;Rare Diseases;rare genetic disorder;Recurrence;Registries;Reporting;Research;research clinical testing;Research Personnel;research study;Risk;Schedule;Singapore;Structural Congenital Anomalies;Syndrome;Testing;United States National Institutes of Health;Variant;working group

PROJECT_TITLE: Gene Curation Expert Panel for Syndromic Disorders

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-GGG-B(50)R]


NIH_SPENDING_CATS: Clinical Research;Infectious Diseases;Kidney Disease;Machine Learning and Artificial Intelligence;Urologic Diseases

ORG_CITY: LOS ANGELES

ORG_DEPT: UROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative The goal of this proposal is to determine the role of bacteria in the growth of calcium-based kidney stones and thus the significance of bacteria to kidney stone disease. Successful completion of this study will provide insight into future strategies to treat kidney stone disease.

PI_NAMEs: SCOTLAND, KYMORA B (contact)

PROGRAM_OFFICER_NAME: RANKIN, TRACY L

PROJECT_TERMS: 3-Dimensional;Affect;appendage;Bacteria;Behavior;biomineralization;Biophysics;bioprinting;Calcium;Calcium ion;Calcium Oxalate;Calculi;career;Cells;Charge;Clinical;Collaborations;comparison control;cost;cost estimate;Crystallization;Data;Deoxyribonucleases;Deposition;Development;Diet;Disease;DNA;Environment;Escherichia coli;Etiology;experience;experimental study;extracellular;fabrication;Fluorescence;Fluorescence Microscopy;Fluorescent in Situ Hybridization;Foundations;Funding;Future;Genetic;Genetic Techniques;Goals;Growth;high resolution imaging;Hydration status;Image;imaging modality;improved;In Situ;In Vitro;in vitro Model;in vivo;Infection;insight;Kidney;Kidney Calculi;kidney cell;Knowledge;Learning;Link;Machine Learning;Mediating;Mentors;Mentorship;Methods;Microbe;microbial;Microbial Biofilms;Microbiology;Microscopy;model organism;Modeling;Molecular;Molecular Biology;Molecular Genetics;Motility;Mutation;Nature;Nephrolithiasis;next generation sequencing;novel;Organelles;Pathogenesis;Pathway interactions;Patients;Physiological;Physiology;Pilum;Play;Polymers;Population;Process;Productivity;Pseudomonas;Pseudomonas aeruginosa;Publications;Raman Spectrum Analysis;Reaction;Research;Research Personnel;Resolution;Rodent Model;Roentgen Rays;Role;Sampling;Scientist;skills;Stents;Surface;Surgeon;Techniques;Testing;tool;Training;urinary;Urinary system;Urinary tract;Urinary tract infection;Urine;Urology;Uropathogen;Work

PROJECT_TITLE: Elucidating the Role of Biofilm-Forming Bacteria in Nephrolithiasis

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


NIH_SPENDING_CATS: Autoimmune Disease;Behavioral and Social Science;Chronic Pain;Clinical Research;Infectious Diseases;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy;Primary Immunodeficiencies;Rare Diseases

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Hidradenitis suppurativa (HS) is a common, chronic inflammatory skin disease that causes severe pain, leading to poor quality of life, chronic opioid use, and elevated suicide risk. This research and career development plan will address critical research gaps by identifying HS pain mechanisms and trajectories to enable personalized medicine, performing a pain management needs assessment, and using stakeholder-engaged research to begin the design of complex interventions to alleviate HS pain. The data generated by this proposal and associated training will enable Dr. Orenstein to become an independent researcher whose work supports the mission of NIAMS by designing, evaluating, and implementing interventions to reduce pain and improve quality of life in HS and other serious skin diseases.

PI_NAMEs: ORENSTEIN, LAUREN ANNE VIGIL (contact)

PROGRAM_OFFICER_NAME: UNDALE, ANITA H

PROJECT_TERMS: 18 year old;Abscess;Absence of pain sensation;Address;Adult;Advocate;Affect;African American population;African Women;Analgesics;Anxiety;Applications Grants;Behavioral;Biometry;Capital;care preference;career;career development;Caring;Central Nervous System;Chronic;chronic inflammatory skin;Cicatrix;Classification;Clinical;Clinical Trials;Communities;Complex;daily functioning;daily pain;Data;Dermatologic;Dermatology;design;Development Plans;Disease;Doctor of Philosophy;effective therapy;Enrollment;Environment;Epidemiology;Evaluation;experience;Frequencies;Functional disorder;Health Services Research;Health system;Heart failure;Heart Rate;Hidradenitis Suppurativa;Impairment;improved;improved outcome;Inflammation;Institution;International;Intervention;intervention mapping;Interview;K-Series Research Career Programs;Linear Regressions;Measurement;Measures;medical schools;medical specialties;Mental Depression;Mentors;Methods;Mission;Mood Disorders;multidisciplinary;multimodality;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;Needs Assessment;Nerve;Neuropathy;Nociception;Numeric Rating Scale;opioid use;Outcome;Outcomes Research;Pain;Pain interference;Pain management;Pain Measurement;pain outcome;Pain quality;pain reduction;painful neuropathy;Palliative Care;Participant;patient oriented;Patient Outcomes Assessments;Patients;Pattern;Persistent pain;personalized medicine;pharmacologic;Phenotype;preference;Prevalence;professor;Prognosis;Prospective Studies;Prospective, cohort study;Quality of life;Recommendation;recruit;Recurrence;Research;research and development;Research Design;Research Personnel;Resources;Role;Safety;Sampling;Sensory;Severities;skills;skin disorder;social;somatosensory;stakeholder perspectives;Statistical Data Interpretation;Stimulus;Structure;suicidal risk;Surveys;Symptoms;systemic inflammatory response;Techniques;Testing;therapy development;Time;tissue injury;Training;treatment response;Validation;Work

PROJECT_TITLE: Pain in Hidradenitis Suppurativa: Phenotypes and Stakeholder Perspectives

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Effects of Indoor Air Pollution;Health Services;Prevention;Primary Health Care;Rural Health;Social Determinants of Health;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

PHR: PROJECT NARRATIVE This study tests the integration of an effective smoke-free homes intervention into the 5As for tobacco cessation within the context of federally qualified health centers. Creation of smoke-free personal environments may catalyze and support the smoking cessation process. If successful, this new approach may reach a broader population of smokers than current efforts which typically focus on the subset of smokers ready to quit.

PI_NAMEs: KEGLER, MICHELLE C (contact)

PROGRAM_OFFICER_NAME: REYES-GUZMAN, CAROLYN

PROJECT_TERMS: Acceleration;Address;Adoption;Alabama;Child;cigarette smoke;Collaborations;Communities;cost;Data;Data Pooling;dissemination trial;effectiveness trial;efficacy testing;efficacy trial;Environment;environmental tobacco smoke exposure;Evaluation Research;Federally Qualified Health Center;Florida;follow-up;Home;Home environment;Household;implementation evaluation;implementation outcomes;innovation;Intervention;Intervention Studies;Low income;Low Income Population;Mind;Modeling;novel strategies;Ohio;Oklahoma;Outcome;Participant;patient oriented;patient population;patient subsets;Patients;Pharmacotherapy;Phase;Population;Population Analysis;Positioning Attribute;Prevention Research;Primary Care;primary care setting;Process;process evaluation;Provider;quitline;Randomized, Controlled Trials;Recommendation;reduce tobacco use;Reporting;Research;Rural;Rural Population;safety net;service delivery;Site;Smoke;Smoke-free home;Smoker;Smoking;smoking cessation;smoking cue;social;socioeconomic disadvantage;Testing;Tobacco Control Research;Tobacco Use Cessation;treatment as usual;United States Preventative Services Task Force;Vulnerable Populations

PROJECT_TITLE: Intergrating a Smoke-Free Home Intervention into the 5As to Support Cessation

STUDY_SECTION: DIRH

STUDY_SECTION_NAME: Dissemination and Implementation Research in Health Study Section[DIRH]


NIH_SPENDING_CATS: Aging;Bioengineering;Clinical Research;Osteoporosis;Physical Injury - Accidents and Adverse Effects;Prevention

ORG_CITY: Athens

ORG_NAME: OSTEODX INC.

ORG_STATE: OH

PHR: OsteoDx’s CBMT technology is intended to remedy the highly significant unmet need for an improved diagnostic identifying persons at high risk of suffering an osteoporosis related fragility fracture. If successful, CBMT will enable much more efficient delivery of anti-osteoporosis medication, greatly reducing the number of fragility fractures and their enormous healthcare cost burden. CBMT can also accelerate the development of new and better anti-osteoporosis therapies.

PI_NAMEs: CLARK, BRIAN C;DICK, ANDREW  (contact)

PROGRAM_OFFICER_NAME: FOX, JENNIFER THERESA

PROJECT_TERMS: Acceleration;Achievement;Adopted;Adoption;Age;Applications Grants;biomaterial compatibility;bone;Bone Density;bone health;bone quality;bone strength;Cadaver;Clinical;clinically significant;commercialization;Computer software;cortical bone;cost;Data Security;Death Rate;design;Development;Devices;Diagnosis;Diagnostic;Diagnostic Equipment;Electromagnetics;Enhancement Technology;Ensure;Equipment;experience;experimental study;Food and Drug Administration Device Approval;Foundations;Fracture;fracture risk;fragility fracture;Health Care Costs;high risk;high risk population;human subject;improved;Individual;Injury;Interview;Lifelong disability;lifestyle factors;manufacture;Market Research;Marketing;Measurement;Measures;mechanical properties;Mechanics;Medical;Medical Device;meetings;Modality;Monitor;novel;Nutritional;Osteoporosis;osteoporosis with pathological fracture;Osteoporotic;Pain;Patients;Performance;Persons;Pharmaceutical Preparations;Phase;Physicians;Positioning Attribute;Postmenopause;Preparation;prevent;Production;prototype;Reproducibility;response;Risk;risk mitigation;Risk Reduction;Roentgen Rays;Safety;Seasons;Series;sex;Small Business Innovation Research Grant;Source;Surveys;System;Technology;Testing;tool;Treatment Effectiveness;ulna;Variant;Woman

PROJECT_TITLE: Development of Cortical Bone Mechanics Technology for Enhancing the Diagnosis of Osteoporosis