NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Injury;Clinical Research;Emergency Care;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Social Determinants of Health;Violence Research;Youth Violence

ORG_CITY: PROVIDENCE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: PROJECT NARRATIVE NICHD has called for improved descriptions of the relationship between real-time social connectedness, peer victimization, and psychological well-being. This innovative 6-month cohort study will use multiple methods of real-time measurement of social media use, in-person interactions, and self-perceptions to identify patterns of social connectivity, peer victimization, and psychological well-being among a high-risk sample of adolescents. Results will inform future in-person and population-level interventions for youth, parents, and communities.

PI_NAMEs: NUGENT, NICOLE R (contact);RANNEY, MEGAN LARIN

PROGRAM_OFFICER_NAME: GILBERT, LEAH KAYE

PROJECT_TERMS: Accident and Emergency department;Adolescent;adverse childhood events;Age;Articulation;Behavior Therapy;behavioral health;Bite;cohort;Cohort Studies;Communities;Computer Models;Conflict (Psychology);cyberbullying;Data;data integration;Data Reporting;Distress;Ecological momentary assessment;Elements;Emotional;Enrollment;Ensure;Environment;Exclusion;experience;Facebook;follow-up;Frequencies;Future;Growth;Health;high risk;high-risk adolescents;improved;in vivo;Influentials;Injury;innovation;Instagram;Intervention;Intervention Studies;Label;Life;Loneliness;Longitudinal cohort study;Longitudinal trends;Measurement;media use;Medical;Mental disorders;Methodology;Methods;Modeling;Moods;multiple data sources;National Institute of Child Health and Human Development;novel;Parents;Participant;Patient Self-Report;Pattern;peer victimization;Personal Satisfaction;Persons;Play;Population;Procedures;prospective;Psyche structure;psychosocial development;recruit;Reporting;Research;Research Project Grants;response;Risk;Role;Sampling;Self Perception;Sexual and Gender Minorities;sexual minority status;social;Social Interaction;Social isolation;social media;Social Processes;Social support;sound;Strategic Planning;Surveys;temporal measurement;Text Messaging;Time;tool;United States;Victimization;Violence;virtual;Well in self;Work;Youth

PROJECT_TITLE: Social Media, Violence, and Social Isolation Among At-Risk Adolescents: Exploring Ground Truth


ADMINISTERING_IC: AI

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Infectious Diseases;Influenza;Pneumonia and Influenza

ORG_CITY: CAMBRIDGE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: CHEMISTRY

ORG_FIPS: US

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

ORG_STATE: MA

PHR: Understanding the factors that shape the extraordinary capacity of RNA viruses like influenza to adapt to selection pressures, ranging from the immune system, to drugs, to new host environments upon zoonotic transmission, is critical for predicting and preventing pathologic viral adaptation and designing effective antiviral drugs and vaccines. By assisting the folding of otherwise defective viral protein variants, hijacked host cell protein folding machineries play a critical role in defining what evolutionary trajectories are available to a virus as it adapts to selection pressures. The proposed research aims to illuminate this phenomenon at the molecular and genomic levels, greatly improving understanding of viral adaptation and evolution at the host- pathogen interface in a way that will not only be fundamentally important but also likely prove valuable in the long-term for the design of novel antiviral strategies.

PI_NAMEs: SHOULDERS, MATTHEW DONALD (contact)

PROGRAM_OFFICER_NAME: BOZICK, BROOKE ALLISON

PROJECT_TERMS: Adaptive Immune System;Adjuvant;Aging;Amino Acid Sequence;Amino Acid Substitution;Amino Acids;Anti-viral Agents;Anti-viral Therapy;Antibodies;antiviral drug development;Biochemical;Biological Models;Biology;biophysical analysis;biophysical properties;biophysical techniques;Biophysics;cell type;Cells;Chemicals;Complex;Computer Models;Computing Methodologies;cost;cross-species transmission;Defect;Dependence;design;dynamic system;Endoplasmic Reticulum;Environment;Evolution;Extinction;Genetic;genome-wide;Genomics;HIV;Human poliovirus;Immune system;improved;Individual;Influenza;Influenza Hemagglutinin;Innate Immune System;insight;invention;Kinetics;Knowledge;Mediating;Methods;Missense Mutation;Modeling;Molecular;Molecular Chaperones;Mutagens;Mutation;mutation screening;neutralizing antibody;novel;Nucleoproteins;Organism;pathogen;Pathologic;Pathway interactions;Pharmaceutical Preparations;Play;Population;Predisposition;pressure;prevent;Process;Production;protein folding;Proteins;proteostasis;Quality Control;Research;Resistance;Resistance development;resistance mechanism;RNA;RNA Viruses;Role;Serial Passage;Shapes;stem;Study models;System;targeted treatment;Testing;Therapeutic;Thermodynamics;transmission process;Treatment Protocols;Vaccines;Variant;Viral;Viral Genome;Viral Proteins;virology;Virus;Virus Replication;Work;Zoonoses

PROJECT_TITLE: Defining the Interplay Between Viral Adaptation and Host Proteostasis

STUDY_SECTION: VIRA

STUDY_SECTION_NAME: Virology - A Study Section[VIRA]


ADMINISTERING_IC: EY

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Clinical Research;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: Project Narrative The first-line treatment option for patients with glaucoma, an eye disease that is the leading cause of irreversible blindness worldwide, is generally intraocular pressure lowering eye drops which are limited in success by: side-effects, lack of response to treatment, and compliance with using medications as prescribed. We have identified a novel intraocular pressure lowering medication called Stanniocalcin-1 (STC-1) that can provide sustained intraocular pressure reduction following a single treatment using a viral vector to express STC-1. We seek to: 1) determine the optimal viral vector that leads to maximal and sustained pressure reduction, 2) test this construct in mice with elevated intraocular pressure and determine the mechanism of action, and 3) test this construct in cats for further preclinical study which will provide valuable insights into safety and efficacy in order to reach our long-term goal of treating patients.

PI_NAMEs: RODDY, GAVIN W (contact)

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: adeno-associated viral vector;adenovirus mediated delivery;analog;Animal Model;anterior chamber;aqueous;Aqueous Humor;Blindness;Cornea;Data;delivery vehicle;Dependovirus;Development;Devices;Dinoprost;Dose;Drug Design;Drug Kinetics;Drug Prescriptions;Eye;Eye diseases;Eyedrops;Felis catus;Glaucoma;Goals;Histologic;Hormones;improved;in vivo;Injections;insight;Intraocular pressure test;Laboratories;lacrimal;Lasers;Latanoprost;Lead;Measures;Mediating;Mentorship;Methodology;Methods;Modeling;mouse model;Mus;normotensive;novel;Ocular Hypertension;ocular surface;Operative Surgical Procedures;optic nerve disorder;Patient Compliance;Patients;Penetration;peptide hormone;Persons;PGF receptor;Pharmaceutical Preparations;pharmacologic;Physiologic Intraocular Pressure;Pigments;pre-clinical;preclinical study;pressure;primary congenital glaucoma;Principal Investigator;Procedures;Property;Prostaglandins;Proteins;receptor;Reducing Agents;Regimen;Research;response;Risk Factors;Safety;Serotyping;side effect;Signal Pathway;Signal Transduction;STC1 gene;Steroids;success;System;Testing;theories;Therapeutic;therapeutic target;Time;Tissues;Topical application;Training;treatment choice;treatment response;Variant;Viral;Viral Load result;Viral Vector;Virus;Wild Type Mouse

PROJECT_TITLE: Virally expressed Stanniocalcin-1 for long-term intraocular pressure reduction


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Chronic Liver Disease and Cirrhosis;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Liver Disease;Prevention;Regenerative Medicine;Substance Misuse

ORG_CITY: DURHAM

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Project Narrative Cirrhosis develops when injured livers do not repair properly and this can lead to liver failure, suffering and death. To prevent these bad outcomes, better tests are needed to predict which patients with cirrhosis are destined to develop a bad clinical outcome. This project will develop tests to identify people with cirrhosis who are likely to develop liver failure and determine whether or not statin therapy can prevent liver failurein patients with cirrhosis.

PI_NAMEs: MOYLAN, CYNTHIA A (contact)

PROGRAM_OFFICER_NAME: DOO, EDWARD

PROJECT_TERMS: 3-hydroxy-3-methylglutaryl-coenzyme A;Address;Adult;Alcohol-Induced Disorders;Alcohols;Anti-Inflammatory Agents;antiretroviral therapy;Bile Acids;Biliary;cancer risk;care providers;Caring;cell type;Cessation of life;Cholesterol;Cirrhosis;Clinical;Clinical Research;Coenzyme A;Communities;comorbidity;Defect;demographics;Development;Diagnostic radiologic examination;disability-adjusted life years;drug induced liver injury;effective therapy;efficacy evaluation;Endoscopy;Enzymes;Evolution;Fibrosis;Functional disorder;functional loss;geranylgeranyl pyrophosphate;Growth;Health;Health system;Hepatic;Hepatocyte;Hepatology;high risk;HIV therapy;HIV/AIDS;Human;Human Resources;Hydroxymethylglutaryl-CoA reductase;Hydroxymethylglutaryl-CoA Reductase Inhibitors;Impairment;improved;improved outcome;Inflammatory;inhibitor;Injury;Institution;Intervention Trial;Interventional radiology;Knowledge;Liver;Liver Cirrhosis;Liver diseases;Liver Dysfunction;Liver Failure;liver function;liver injury;Liver parenchyma;liver preservation;Liver Regeneration;liver transplantation;Longitudinal cohort study;Malignant neoplasm of liver;Malignant Neoplasms;Medical;Medical Oncology;Metabolic;Metabolic syndrome;Metabolism;mevalonate;modifiable risk;Morbidity - disease rate;mortality;multidisciplinary;Natural regeneration;non-alcoholic fatty liver disease;North Carolina;novel strategies;Obesity;older patient;Older Population;Operative Surgical Procedures;Organ;Organ failure;Outcome;Oxidoreductase;Pathology;Pathway interactions;Patients;personalized approach;personalized medicine;Persons;Pharmaceutical Preparations;Play;Population;Positioning Attribute;Pre-Clinical Model;pre-clinical research;prevent;Prevention;Primary Health Care;problem drinker;programs;regenerative;Regenerative pathway;repaired;Research;Risk;Role;Rural Population;Safety;Services;Severities;Signal Pathway;Suburban Population;success;Testing;Therapeutic;Tissues;United States;Urban Population;Viral hepatitis;Work

PROJECT_TITLE: Prediction and Prevention of Hepatic Decompensation in Patients with Cirrhosis


ADMINISTERING_IC: AG

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_CITY: NEW YORK

ORG_DEPT: GENETICS

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: Project Narrative  While night-eating increases the risk of obesity and other aging-related comorbidities, such as type-2 diabetes and cardiovascular disease, time-restricted feeding has been found to ameliorate these effects. This proposed work will investigate how time-restricted feeding accelerates lipid metabolism to confer health span benefits and in the context of diet-induced obesity. This will improve our understanding of the molecular mechanisms underlying the health benefits of time-restricted feeding and the therapeutic potential of time- restricted feeding in diet-induced obesity.

PI_NAMEs: GATTO, JARED ANTHONY (contact)

PROGRAM_OFFICER_NAME: FU, YI-PING

PROJECT_TERMS: Acceleration;Affect;Age;age effect;Aging;aging related;American;Animals;anti aging;Automobile Driving;Autophagocytosis;Blood Glucose;Body Weight decreased;Brain;Candidate Disease Gene;Cardiovascular Diseases;Catabolism;circadian;Circadian gene expression;circadian pacemaker;circadian regulation;Clustered Regularly Interspaced Short Palindromic Repeats;comorbidity;Data;Diet;diet-induced obesity;Dietary Component;Dietary Intervention;differential expression;Drosophila genus;Drosophila melanogaster;Eating;Energy Intake;experimental study;extend lifespan;Fasting;Fat Body;Fatty acid glycerol esters;feeding;fly;Food;Gene Expression;Generations;Genes;Genetic;Goals;Health;Health Benefit;healthspan;High Fat Diet;Hour;Human;human old age (65+);improved;Inflammation;Insulin Resistance;interest;Intestines;knock-down;Life;life span;Link;lipid metabolism;Lipids;Mammals;Mediating;Metabolic Pathway;Metabolism;model organism;Modeling;Molecular;Mus;Muscle;mutant;Non-Insulin-Dependent Diabetes Mellitus;Obesity;obesity prevention;obesity risk;Organ;Organism;Oxidative Stress;Pathology;Pathway interactions;Peripheral;Persons;Phenotype;Physiological;prevent;programs;protein aggregation;Research;Resistance;Role;Sleep;Starvation;sugar;Testing;Therapeutic;Thin Layer Chromatography;Time;Time-restricted feeding;timeline;Tissues;tool;transcriptome sequencing;Work

PROJECT_TITLE: Mechanisms underlying the effects of time-restricted feeding on lipid metabolism

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F06-B(20)L]


ADMINISTERING_IC: HS

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

PHR: PROJECT NARRATIVE Over 3.4 million patients received home healthcare (HHC) in 2018, and this number is expected to increase due to an aging population. Socioeconomically disadvantaged HHC patients may be more prone to infection. This study will be the first to examine health disparities in infections in HHC, explore infection prevention and control (IPC) related knowledge, attitudes, practices among HHC patients and/or their caregivers and develop and pilot test a multi-modal intervention to improve IPC practices at home.

PI_NAMEs: SHANG, JINGJING  (contact)

PROGRAM_OFFICER_NAME: MILLER, MELISSA

PROJECT_TITLE: Disparities in Infection in Home Health and Patients/Caregivers' Perceptions (Dis-Infection in HHC)

STUDY_SECTION: HSQR

STUDY_SECTION_NAME: Healthcare Patient Safety and Quality Improvement Research[HSQR]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Clinical Research;Colorectal Cancer;Digestive Diseases;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunotherapy;Prevention;Racial and Ethnic Minority Health Research

ORG_CITY: CLEVELAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

ORG_STATE: OH

PHR: Immune function is a key determinant of clinical outcomes in colorectal cancer. Compelling evidence supports that variability in the tumor immune microenvironment across diverse racial/ethnic populations may play an important role in observed disparities in cancer outcomes, including response to therapy and survival. Here, we investigate race/ethnicity, genetic ancestry, epidemiologic risk factors, and clinical variables associated with T cell profiles to better understand potential immunological drivers of colorectal cancer outcome disparities between Latinxs and non-Hispanic Whites as well as across Latinx subgroups.

PI_NAMEs: SCHMIT, STEPHANIE L. (contact)

PROGRAM_OFFICER_NAME: UMAR, ASAD

PROJECT_TERMS: Accounting;Address;Admixture;admixture mapping;African;African American;African American population;African American Women;African ancestry;American;Aspirin;Autoimmune;Back;biobank;Biological;Biological Markers;Body mass index;C-reactive protein;cancer care;cancer health disparity;cancer therapy;Caribbean region;caucasian American;CD8-Positive T-Lymphocytes;Clinical;Clinical Data;Clonality;Colorectal Cancer;Communities;cytokine;Cytotoxic T-Lymphocytes;Data;density;Development;differential expression;Disparity;DNA;Epidemiologic Factors;Epidemiology;Ethnic Origin;Ethnic Population;European;Event;exhaustion;experience;FDA approved;Genes;Genetic;genetic architecture;Genetic Variation;genomic locus;Genotype;Germ Lines;Goals;Hispanic;Immune;immune cell infiltrate;Immune checkpoint inhibitor;immune function;Immune response;Immunobiology;Immunofluorescence Immunologic;Immunologic Factors;Immunologics;Immunotherapy;Indigenous American;Inflammation;Inflammatory;Latino;Latino Population;Latinx;Latinx population;Link;liquid crystal polymer;Lymphocyte;Malignant Breast Neoplasm;Malignant neoplasm of prostate;Malignant Neoplasms;Measures;men;Microsatellite Instability;Minority;Minority Groups;Molecular Epidemiology;Molecular Epidemiology of Cancer;molecular subtypes;mortality;Natural Selections;Neoplasm Metastasis;Not Hispanic or Latino;Obesity;Outcome;outcome disparities;Participant;patient population;Patient Self-Report;pembrolizumab;Play;Population;Population Heterogeneity;Predictive Factor;Prevention strategy;prognostic;Prognostic Factor;Proteins;Protocols documentation;Puerto Rico;Race;racial diversity;racial population;Reaction;Research;Resources;response;Risk Factors;Role;Shapes;Site;Smoking;sociodemographic factors;Spatial Distribution;Subgroup;survival disparity;T cell infiltration;T cell response;T-cell diversity;T-Cell Receptor;T-cell receptor repertoire;T-Lymphocyte;Testing;Tissue Microarray;translational potential;Treatment outcome;treatment response;treatment strategy;trend;tumor;tumor microenvironment;Tumor-associated macrophages;tumor-immune system interactions;Tumor-Infiltrating Lymphocytes;Variant;White Women

PROJECT_TITLE: Variation in tumor-associated immune profiles and colorectal cancer outcomes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OBT-J(55)R]


ADMINISTERING_IC: AR

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Arthritis;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Osteoarthritis;Physical Rehabilitation;Rehabilitation

ORG_CITY: STORRS-MANSFIELD

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF CONNECTICUT STORRS

ORG_STATE: CT

PHR: Project Narrative Despite extensive rehabilitation, over 250,000 anterior cruciate ligament (ACL) injuries occur each year in the United States often resulting in neuromuscular dysfunction and the development of knee osteoarthritis. However, purposeful, induced asymmetric walking has been shown to override altered neuromuscular impairment to restore healthy gait patterns. Thus, my goal is to conduct a comparative research-focused study to evaluate the effectiveness of different asymmetric walking protocols and then utilize computational modeling and machine learning to model knee loading in the clinic to determine the optimal asymmetric walking protocol to restore healthy gait in post-ACL reconstruction individuals.

PI_NAMEs: MORGAN, KRISTIN  (contact)

PROGRAM_OFFICER_NAME: WASHABAUGH, CHARLES H

PROJECT_TERMS: Adoption;algorithm development;Algorithms;Analysis of Variance;anterior cruciate ligament injury;anterior cruciate ligament reconstruction;biomechanical model;Biomechanics;Biomedical Engineering;Biomedical Research;career;Caring;Clinic;Clinical;clinical translation;comorbidity;comparative;Comparative Study;Computer Models;Data;Data Analytics;Dedications;Development;Effectiveness;effectiveness evaluation;Evaluation;Functional disorder;Future;Gait;gait examination;gait rehabilitation;Gait speed;Goals;Health Care Costs;Impairment;improved;Individual;Injury;innovation;Institution;Intervention;joint loading;Knee;Knee Osteoarthritis;Laboratories;Limb structure;Machine Learning;Measures;mechanical load;Mechanics;Medicine;Mentored Research Scientist Development Award;Mentors;Mentorship;Modeling;Monitor;neuromuscular;novel;novel therapeutic intervention;novel therapeutics;Orthopedics;Outcome;Participant;Patients;Pattern;Performance;Persons;Physical therapy;Population;primary outcome;Protocols documentation;Public Health;Quality of life;recruit;Rehabilitation Outcome;Rehabilitation therapy;Research;Research Activity;Research Personnel;Research Training;Resources;response;restoration;return to sport;signal processing;simulation;skills;Stroke;success;Testing;Therapeutic;Time;Training;Training Activity;Translating;Translational Research;Traumatic Arthropathy;United States;United States National Institutes of Health;Walking;Work

PROJECT_TITLE: Asymmetric Walking Protocol for Optimal Post-ACL Reconstruction Rehabilitation

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Heart Disease;Hypertension

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE Heart failure with preserved ejection fraction (HFpEF) is a critical public health problem, and there is an urgent need to identify therapies that target mechanisms of progression of HFpEF. We propose a novel investigation of the role of two common antihypertensive medications, amlodipine besylate and metoprolol succinate, in targeting key physiologic abnormalities in HFpEF. Our mechanism-driven approach will enhance our understanding of the pathophysiology of HFpEF and characterize the mechanistic potential of these common antihypertensive agents to reduce progression and improve symptom management in this disease.

PI_NAMEs: COHEN, JORDANA B. (contact)

PROGRAM_OFFICER_NAME: TINSLEY, EMILY

PROJECT_TERMS: Adrenergic Agents;Adrenergic beta-Antagonists;Adult;Aerobic;Affect;Amlodipine;Anti-Hypertensive Agents;beta-adrenergic receptor;Blood Pressure;Calcium Channel;Calcium Channel Blockers;Cardiac Output;Cardiomyopathies;Cardiovascular Physiology;chronotropic;Cities;Clinical;clinical practice;Cross-Over Trials;Data;Development;Dihydropyridines;Disease;Doppler Echocardiography;EFRAC;evidence base;Exercise;exercise capacity;Exercise Physiology;Functional disorder;General Population;Goals;Guidelines;Heart Block;Heart failure;heart failure with reduced ejection fraction;hemodynamics;High Prevalence;Home;Hypertension;hypertension control;Impairment;improved outcome;Individual;Intervention;Investigation;Kansas;Left;Left Ventricular Ejection Fraction;Left Ventricular Function;Measurement;Measures;Mediating;Metoprolol Succinate;modifiable risk;Morbidity - disease rate;mortality;novel;Participant;patient population;Pattern;Pharmaceutical Preparations;Pharmacoepidemiology;pharmacologic;Physical Function;Physiological;Physiology;preservation;pressure;Public Health;Quality of life;Questionnaires;Randomized;Randomized, Controlled Trials;Recommendation;response;Rest;Risk Factors;Role;Source;symptom management;symptomatic improvement;targeted treatment;trial design;United States;Vasodilation;Ventricular

PROJECT_TITLE: Blockade of calcium channels and beta adrenergic receptors for physiologic abnormalities in heart failure with preserved ejection fraction (BLOCK HFpEF)

STUDY_SECTION: CICS

STUDY_SECTION_NAME: Clinical and Integrative Cardiovascular Sciences Study Section[CICS]


NIH_SPENDING_CATS: Biomedical Imaging;Clinical Research;Eye Disease and Disorders of Vision;Mental Health;Neurosciences;Psychosis

ORG_DEPT: NEUROLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Project Narrative Spontaneous brain activity consumes a major fraction of the brain’s energy cost and influences perceptual and cognitive functions. The mechanisms of spontaneous activity’s involvement in perceptual processing are poorly understood, hampering our ability to explain and treat perceptual disturbances in a variety of illnesses including macular degeneration, neurodegenerative disorders, and schizophrenia. By providing a new framework for understanding spontaneous brain activity’s functional role in perceptual processing, the results of this work will lay the foundation to better treat perceptual disorders such as hallucination.

PI_NAMEs: HE, BIYU JADE (contact)

PROGRAM_OFFICER_NAME: FLANDERS, MARTHA C

PROJECT_TITLE: Establishing a Unified Framework of Spontaneous Brain Activity in Perception

STUDY_SECTION: HCMF

STUDY_SECTION_NAME: Human Complex Mental Function Study Section[HCMF]


NIH_SPENDING_CATS: Back Pain;Bioengineering;Biomedical Imaging;Biotechnology;Chronic Pain;Clinical Research;Disability Research;Neurosciences;Pain Research;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

ORG_CITY: LOS ANGELES

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

ORG_STATE: CA

PHR: PROJECT NARRATIVE Low back pain is one of the most frequent causes of morbidity and disability in the United States. To date there are no reliable non-invasive ways to detect the origin of discogenic low back pain. Out goal is to develop a quantitative magnetic resonance imaging method that will provide reproducible and accurate detection of the origin of the low back pain and the effect of novel targeted therapies such as stem cell injections.

PI_NAMEs: LI, DEBIAO  (contact)

PROGRAM_OFFICER_NAME: MARQUITZ, ARON

PROJECT_TERMS: Absenteeism at work;accurate diagnosis;Aging;American;Anatomy;Back Pain;Biology;bone marrow mesenchymal stem cell;cardiovascular imaging;Chemicals;Chronic low back pain;Clinical;Compensation;Consumption;Data;data acquisition;Dehydration;Detection;Development;Diagnosis;Diagnostic Procedure;Diffusion;Dimensions;disability;disc regeneration;Family suidae;Goals;Grant;healthy volunteer;Height;Human;Image;imaging modality;Imaging Techniques;Immobilization;improved;Individual;Injections;Intervertebral disc structure;intervertebral disk degeneration;Longitudinal Studies;Low Back Pain;Magnetic Resonance Imaging;Maps;Measures;Medical;Mesenchymal Stem Cells;Metabolism;Methods;Miniature Swine;Modeling;Molecular;molecular marker;Monitor;Morbidity - disease rate;Motion;multitask;Nature;new therapeutic target;nucleus pulposus;Occupations;Operative Surgical Procedures;Pain;pain patient;pain relief;Pathologic;Patients;Physicians;porcine model;Process;Property;Protons;Publishing;reconstruction;Reproducibility;Scanning;solute;Source;Spinal Fusion;stem cell therapy;stem cells;System;T2 weighted imaging;targeted treatment;Techniques;Therapeutic Effect;Time;Tissues;tool;treatment response;United States;Vertebral column;Water

PROJECT_TITLE: Quantitative Multiparametric MRI to Assess the Effect of Stem Cell Therapy on Chronic Low Back Pain

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]


ADMINISTERING_IC: GM

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: IRMO

ORG_NAME: INTEGRATED MICRO-CHROMATOGRAPHY SYSTEMS, INC.

ORG_STATE: SC

PHR: Project Narrative Sialoglycans are sialic acid-containing glycans that play critical roles in many biological events and in diseases. The diversity of sialoglycans is magnified by a variety of glycosidic linkages, the sequences, and classes of underlying glycans, as well as the different types of sialic acid forms. Providing affordable, easy to use reaction kits to synthesize different sialoglycans, and access of structurally defined sialoglycans will advance sialic acid- related basic research and the development of potential diagnostics and therapeutics.

PI_NAMEs: LEE, LIM ANDREW (contact)

PROGRAM_OFFICER_NAME: BOND, MICHELLE RUEFFER

PROJECT_TERMS: Acids;Amines;Animals;Bacterial Infections;Basic Science;Binding Proteins;Biological;Biotinylation;candidate identification;Carbon;Cell surface;Chemicals;Collaborations;commercialization;commercialization readiness;Communities;Complex;cost;Cytolysis;Diagnostic;Disaccharides;Disease;Enzymes;Equilibrium;Event;Family;Family member;Fermentation;Future;Glycolipids;Glycoproteins;glycosylation;glycosyltransferase;Goals;Homeostasis;Homologous Gene;Human;Human Biology;Human body;human disease;Human Milk;Human Pathology;Hydrophobicity;immunoregulation;improved;In Situ;Industry;Infrastructure;innovation;large scale production;Malignant Neoplasms;Mammals;mannosamine;manufacture;Methods;Molecular Probes;Monitor;Monosaccharides;mutant;N-Acetylneuraminic Acid;Neoplasm Metastasis;Oligosaccharides;Pathogenesis;Pathologic Processes;Physiological Processes;Play;Polysaccharides;Price;Process;Production;Productivity;Property;Protein Engineering;Protocols documentation;Reaction;Reaction Time;Reagent;Research;research and development;Role;Sales;Sialic Acids;sugar;sugar nucleotide;System;Techniques;Testing;Therapeutic;therapeutic development;Vertebral column;Virus Diseases

PROJECT_TITLE: Affordable sialoglycans and associated reagents for expanded chemoenzymatic production


NIH_SPENDING_CATS: Cancer;Clinical Research;Genetics;Immunotherapy;Lung;Lung Cancer;Rare Diseases

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: PROJECT NARRATIVE Small cell lung cancer (SCLC) remains relatively refractory to multiple therapeutic modalities, including immune checkpoint blockade, despite its high tumor mutation burden. This proposal seeks to exploit newfound immunologic vulnerabilities of SCLC conferred by epigenetic control of MHC Class I antigen presentation. Rational targeting of distinct immunologic subtypes of SCLC could lead to a deeper understanding of epigenetic modulation of immunogenicity, and, ultimately, novel immunotherapies for this treatment-refractory tumor.

PI_NAMEs: MAHADEVAN, NAVIN  (contact)

PROGRAM_OFFICER_NAME: LIM, SUSAN E

PROJECT_TERMS: Advisory Committees;Anatomy;anti-tumor immune response;Antigen Presentation;Antigens;Area;Biological Assay;career;career development;CD3 Antigens;Cell Culture System;Cell Line;cell mediated immune response;Cell model;Cell-Mediated Cytolysis;Cells;Cellular immunotherapy;chemotherapy;Clinical Services;clinical training;Communication;Coupled;Cytolysis;Cytotoxic Chemotherapy;Dana-Farber Cancer Institute;Data;Defect;derepression;Development;Down-Regulation;Elements;Endogenous Retroviruses;Epigenetic Process;epigenetic regulation;Epitopes;experience;experimental study;Expression Profiling;Faculty;Flow Cytometry;Future;Gene Expression Profiling;Genetic;Genetic Transcription;Genomics;Goals;Heterogeneity;Histocompatibility Antigens Class I;Homing;Hospitals;Immune;immune cell infiltrate;immune checkpoint blockade;Immune Targeting;Immunobiology;Immunofluorescence Immunologic;immunogenic;immunogenicity;Immunologics;Immunophenotyping;immunoregulation;Immunotherapy;improved;in silico;In Vitro;in vitro Assay;in vivo;Inflammatory;insight;International;Knowledge;Laboratories;Leadership;Leukocytes;Ligands;Lung;Malignant Epithelial Cell;Malignant Neoplasms;Manuscripts;Mass Spectrum Analysis;medical schools;Medicine;meetings;Mentors;Mesenchymal;Methods;MHC Class I Genes;mid-career faculty;Minor;Modality;Modeling;Molecular;molecular diagnostics;molecular pathology;Mutation;Natural Killer Cell toxicity;Natural Killer Cells;neoplastic cell;Neuroendocrine Carcinoma;Neurosecretory Systems;novel;novel marker;novel vaccines;oncofetal antigen;Pathology;Patients;Peptides;Phenotype;Physicians;Population;Predisposition;programmed cell death ligand 1;programs;Proteins;PTPRC gene;Publishing;Recovery;Refractory;Refractory Disease;Regulation;Research;Resistance;Resolution;response;Sampling;Scientist;skills;Slide;small cell lung carcinoma;Source;Specimen;Survival Rate;System;T-Lymphocyte;Testing;Therapeutic;three dimensional cell culture;three-dimensional modeling;tool;Training;Training Programs;transcriptome sequencing;tumor;Tumor Antigens;tumor immunology;tumor microenvironment;tumor-immune system interactions;Vascularization;Woman;Work

PROJECT_TITLE: Targeting the immunologic vulnerabilities of small cell lung carcinoma

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


ADMINISTERING_IC: HD

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_DEPT: PSYCHIATRY

PHR: PROJECT NARRATIVE – Overall The purpose of the renewal of the Duke Autism Center of Excellence is to apply cutting-edge, translational digital health and computational methods to develop more effective tools for early autism screening and for objectively monitoring changes in children’s behavior, and to discover novel, brain-based biomarkers that can be used for stratification and to assess target engagement in clinical trials with young autistic children. Our long-term vision is to transform how clinical care is delivered by providing innovative solutions that address long-standing barriers in access to care and enhance our ability to evaluate interventions that will improve quality of life of autistic children and their families.

PI_NAMEs: DAWSON, GERALDINE  (contact)

PROGRAM_OFFICER_NAME: KAU, ALICE S

PROJECT_TERMS: 6 year old;Address;Age;Age Months;autism biomarker;autism spectrum disorder;autistic;autistic children;Automated Clinical Decision Support;Behavior;behavioral outcome;Biological Markers;biomarker discovery;Birth;Blue Cross;Blue Shield;Brain;brain based;Caregivers;Caring;Child;Child Behavior;Clinical;clinical care;clinical decision support;Clinical Trials;Code;Collaborations;computer science;Computer Vision Systems;Computing Methodologies;Data;Data Analyses;data management;Data Science;Data Set;design;Development;Devices;Diagnosis;digital applications;digital health;digital phenotyping;Discrimination;Early Diagnosis;Early identification;Electroencephalography;electronic health data;Electronic Health Record;Elements;Engineering;Equity;Ethnic Origin;Factor Analysis;Family;Future;gastrointestinal;Goals;health data;Health Services Accessibility;Health system;Home;implementation science;improved;indexing;Infant;innovation;insight;Intellectual functioning disability;Intervention;Language;literacy;Machine Learning;machine learning method;Measures;Medicaid;Medical;member;Methods;Monitor;multimodality;Natural Language Processing;Nature;neglect;neural;neural network;Neurosciences;North Carolina;novel;novel strategies;Outcome;Outcome Measure;outreach;Parent-Child Relations;Participant;Pathway Analysis;Pattern;Pediatrics;Phase;Population;Population Heterogeneity;prediction algorithm;predictive modeling;Predictive Value;Prevalence;primary care clinic;primary care provider;Provider;Psychiatry;Psychology;Qualifying;Quality of life;Questionnaires;Race;recruit;remote administration;Research;screening;Screening procedure;sex;social attention;Stratification;success;support tools;Testing;Toddler;tool;Universities;usability;Video Recording

PROJECT_TITLE: Duke Autism Center of Excellence: A translational digital health and computational approach to early identification, outcome monitoring, and biomarker discovery in autism


NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Brain Disorders;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Prevention

PROJECT_TERMS: Accounting;Address;Advisory Committees;autism spectrum disorder;autistic children;benefit sharing;Biological Markers;biomarker discovery;Brain;brain based;career;Clinical;clinical care;Clinical Trials;Collaborations;Communication;Communities;community engagement;Computer software;Computing Methodologies;cost effectiveness;Data;Data Analyses;data management;Databases;Decision Making;digital health;Early identification;Ensure;Environment;Equity;Ethics;Expenditure;Faculty;Family;Goals;Good Clinical Practice;Guidelines;Health Services Accessibility;Human Resources;improved;Individual;Infrastructure;innovation;insight;Institution;Institutional Review Boards;Intervention;Knowledge;meetings;member;Monitor;Occupational activity of managing finances;Outcome;Outcome Measure;outreach;Patient Recruitments;Phase;Policies;Postdoctoral Fellow;Principal Investigator;Procedures;Process;Productivity;programs;Progress Reports;Publications;Quality Control;Quality of life;Recommendation;Regulation;Research;Research Personnel;Research Project Grants;Resources;Screening procedure;Stratification;Students;Sum;synergism;Technology;Underrepresented Populations;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Administrative Core

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIB-T]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Neurosciences

ORG_CITY: SAINT LOUIS

ORG_DEPT: NEUROSURGERY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE The objective of the proposal is to understand how amygdala activation affects other medial temporal lobe structures to prioritize long-term memories. The project is relevant to disorders of memory and to disorders involving affect, including traumatic brain injury and post-traumatic stress disorder.

PI_NAMEs: WILLIE, JON TIMOTHY (contact)

PROGRAM_OFFICER_NAME: RANGEL GOMEZ, MAURICIO

PROJECT_TERMS: Affect;Amygdaloid structure;Anatomy;Anterior;Arousal;authority;awake;Basic Science;Complex;Coupling;design;Disease;Electric Stimulation;Electrodes;Electrophysiology (science);Emotional;emotional experience;emotional functioning;Event;Evoked Potentials;experience;Frequencies;Hippocampus;Human;Image;improved;Individual;Investigation;Location;long term memory;Longevity;Maps;medial temporal lobe;Mediating;member;Memory;memory consolidation;Memory Disorders;memory process;memory recognition;Mental Health;Movement;neural;neural network;neuromechanism;Neurons;neurosurgery;novel therapeutics;Outcome;Output;Patients;Performance;Phase;Physiologic pulse;Post-Traumatic Stress Disorders;Process;Rattus;Regional Anatomy;Research;response;Role;spatial memory;Structure;Testing;Time;Traumatic Brain Injury

PROJECT_TITLE: Mechanisms of Amygdala-Mediated Memory Enhancement in Humans

STUDY_SECTION: LAM

STUDY_SECTION_NAME: Neurobiology of Learning and Memory Study Section[LAM]


NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Brain Disorders;Clinical Research;Health Services;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Prevention;Telehealth

PI_NAMEs: FRANZ, LAUREN  (contact)

PROJECT_TERMS: Acceleration;Address;adult with autism spectrum disorder;advocacy organizations;Advocate;autism community;autism spectrum disorder;autistic;autistic children;Awareness;behavioral outcome;Biological Markers;biomarker discovery;Brain;brain based;Businesses;career;career development;Child;Clinic;clinical care;Clinical Sciences;Clinical Trials;Collaborations;Communication;Communities;community engaged research;community engagement;Computing Methodologies;Data Analyses;data management;digital health;dissemination science;Early identification;Education;Effectiveness;Ensure;Equity;ethnic diversity;Event;Faculty;Family;Family member;Friends;Funding;Goals;Government;Health Personnel;Health Services Accessibility;Healthcare;Historically Black Colleges and Universities;Home;improved;Individual;individuals with autism spectrum disorder;innovation;insight;interest;International;Intervention;Investigation;Lead;Life;Monitor;Nonprofit Organizations;North Carolina;novel;Outcome;Outcome Measure;outreach;Parents;Participant;Persons;Phase;Policies;Postdoctoral Fellow;Press Releases;Program Development;Provider;Quality of life;Race;Racial Equity;recruit;Research;Research Personnel;Research Priority;Research Support;risk/benefit ratio;Scientist;screening;Screening procedure;Sensory;social media;Sports;Stratification;Students;symposium;tool;Translating;Translational Research;trend;Underrepresented Populations;United States National Institutes of Health;Universities;Vision;web site;Work

PROJECT_TITLE: Dissemination and Outreach Core


NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Brain Disorders;Clinical Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Prevention

PI_NAMEs: COMPTON, SCOTT N (contact)

PROJECT_TERMS: Adaptive Behaviors;Address;adult with autism spectrum disorder;Advisory Committees;autism biomarker;autism spectrum disorder;autistic children;Behavioral;behavioral outcome;Biological Markers;biomarker discovery;brain based;Caregivers;Caring;Child;Clinical Trials;Collaborations;Communication;Computer Vision Systems;Computing Methodologies;Consent;Data;data acquisition;Data Analyses;data cleaning;Data Collection;data integrity;data management;data quality;Data Reporting;Data Set;data sharing;Data Storage and Retrieval;data submission;Databases;Dedications;demographics;design;Detection;Development;Devices;Diagnostic;digital health;digital phenotyping;Doctor of Philosophy;Early identification;Electroencephalography;Ensure;Equipment;Equity;experience;Faculty;Family;file format;Goals;Health Insurance Portability and Accountability Act;improved;Individual;individuals with autism spectrum disorder;informatics infrastructure;innovation;Knowledge;Language;Leadership;Manuals;Measurement;Measures;Methodology;Methods;Monitor;Neurocognitive;novel;Outcome;Outcome Measure;outreach;Participant;participant retention;Patient Recruitments;Pattern;Phase;Play;Policies;Preparation;Procedures;Process;Productivity;programs;Protocols documentation;Publications;quality assurance;Quality Control;recruit;Reporting;Reproducibility of Results;Research;Research Methodology;Research Personnel;Role;Science;Scientist;screening;Screening procedure;Secure;Security;social communication;Standardization;Statistical Data Interpretation;Structure;Surveys;Testing;timeline;tool;Training;virtual;Work

PROJECT_TITLE: Data Management and Analysis Core


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Immunotherapy;Neurofibromatosis;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Precision Medicine;Rare Diseases

PHR: NARRATIVE The goal of this collaborative translational research project is to utilize insight into cell signaling, cancer biology, immunology, mouse tumor models and developmental therapeutics to rationally develop and test new combination therapies in patients with unresectable NF1 MPNSTs. This work will be performed as a partnership between Karen Cichowski (extramural PI, basic science, preclinical studies), Brigitte Widemann (intramural PI, clinical studies), AeRang Kim (extramural co-PI, clinical studies) and Jack Shern (intramural Co-PI basic science, correlative studies on clinical trials) to enhance the translation of basic biological discoveries into clinical applications for NF1 patients. Ultimately this effort will provide the foundation for an iterative enterprise, in that insight and samples from the clinic will be used to help develop new therapeutic approaches.

PI_NAMEs: CICHOWSKI, KAREN M (contact)

PROGRAM_OFFICER_NAME: OLKHANUD, PUREVDORJ BALJINNYAM

PROJECT_TERMS: Affect;Animal Model;anti-PD-L1 antibodies;Applications Grants;Back;Basic Science;bench to bedside;Biological;Biology;biomarker identification;Biopsy;Boston;Bromodomain;Cancer Biology;Cells;Chemotherapy and/or radiation;Child;Clinic;Clinical;clinical application;clinical center;Clinical Investigator;Clinical Research;clinical translation;Clinical Trials;Collaborations;Combined Modality Therapy;Correlative Study;crizotinib;Data;design;Development;Developmental Therapeutics Program;Disease;District of Columbia;DNA Sequence Alteration;Dose;effective therapy;Epigenetic Process;Evaluation;Extramural Activities;Foundations;Future;Gene Expression Profile;Genomics;Goals;Grant;Hereditary Malignant Neoplasm;Hospitals;Human;Immune checkpoint inhibitor;Immunologics;Immunology;immunoreactivity;Immunotherapy;improved;In Vitro;in vivo;Individual;Industry;Infrastructure;inhibitor;insight;Institution;Malignant Neoplasms;Medical center;MEKs;Modeling;mouse model;multidisciplinary;Mus;Nature;Neoplasm Metastasis;neoplasm resource;Neurofibromatoses;Neurofibromatosis 1;Neurofibrosarcoma;new combination therapies;novel;novel drug class;novel therapeutic intervention;novel therapeutics;open label;participant enrollment;Patient Outcomes Assessments;Patients;Pediatric Oncology;pharmacodynamic biomarker;phase 1 study;phase 2 study;Phase I/II Clinical Trial;Phase I/II Trial;Phosphotransferases;pre-clinical;preclinical study;predicting response;prototype;Refractory;Refractory Disease;Relapse;Research Personnel;Research Project Grants;Resistance;resistance mechanism;Resources;response;response biomarker;Sampling;Sarcoma;Schedule;Science;Scientist;Series;Signal Transduction;small molecule inhibitor;Soft tissue sarcoma;standard of care;Syndrome;targeted treatment;Testing;Therapeutic;therapeutic development;therapeutic target;therapy development;transcriptomics;Translating;Translational Research;translational scientist;Translations;tumor;tumor DNA;tumor microenvironment;tumorigenesis;United States National Institutes of Health;Unresectable;Woman;Work

PROJECT_TITLE: Preclinical-Clinical Trials Collaboration to effectively advance new combination therapies for malignant peripheral nerve sheath tumors


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

PHR: Narrative In this proposal we will study how an important protein in Parkinson’s Disease, called alpha- Synuclein, undergoes alterations in its molecular structure that lead to the death of neurons. The research is important because it will lead to a deeper understanding of what goes wrong in the disease and will enable new approaches to the discovery of novel medicines to treat the disease.

PI_NAMEs: SACHS, JONATHAN N (contact)

PROGRAM_OFFICER_NAME: SARRAF, SHIREEN AKHAVAN

PROJECT_TERMS: advanced simulation;Affinity;algorithm development;alpha synuclein;Alzheimer's Disease;Amino Acid Motifs;Amino Acid Sequence;Amino Acids;Back;beta pleated sheet;Biological Assay;Biology;biophysical analysis;biophysical tools;Biophysics;Catalogs;Cell Line;Cell model;cell type;Cells;Chemicals;Collaborations;Color;Communities;Computer Models;Coupled;Cytoprotection;cytotoxic;cytotoxicity;Data;Dementia;design;Disease;drug discovery;Event;Experimental Designs;Fluorescence;Fluorescence Resonance Energy Transfer;Goals;high throughput screening;Induced Neurons;inhibitor;innovation;insight;Investigation;kinetic model;Kinetics;Label;Medicine;Methodology;Microscopy;Modeling;Molecular;molecular modeling;molecular scale;Molecular Structure;Molecular Weight;Monitor;monomer;Morphologic artifacts;mutant;Mutation;Nature;neuron loss;Neurons;Neurosciences;new therapeutic target;novel;novel strategies;Outcome;Paper;Parkinson Disease;Pathology;Pathway interactions;Positioning Attribute;prevent;protein folding;protein misfolding;Proteins;Protocols documentation;Publications;rational design;Recording of previous events;Research;Research Personnel;Resolution;Science;screening;Series;Signal Transduction;small molecule;small molecule inhibitor;Structure;System;Techniques;Technology;Testing;Therapeutic;Time;time use;tool;Total Internal Reflection Fluorescent;Toxic effect;Variant;Work

PROJECT_TITLE: Exploiting New Fibril Structures to Understand the Biophysical Basis for Oligomerization and Toxicity of Alpha-Synuclein

STUDY_SECTION: BPNS

STUDY_SECTION_NAME: Biophysics of Neural Systems Study Section[BPNS]


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Health Services;Intellectual and Developmental Disabilities (IDD);Machine Learning and Artificial Intelligence;Mental Health;Neurosciences;Pediatric;Prevention;Primary Health Care;Telehealth

PROJECT_TERMS: Address;Affect;Age Months;assessment application;Assessment tool;Autism Diagnosis;autism spectrum disorder;autistic;autistic children;Automated Clinical Decision Support;Behavior;Behavior assessment;behavior measurement;behavioral outcome;behavioral response;Biological Markers;biomarker discovery;Black race;brain based;Caregivers;Cellular Phone;Child;Child Behavior;Child Development;children of color;Clinical;clinical care;clinical decision support;Clinical Trials;Code;Collaborations;computer scientist;Computer Vision Systems;Computing Methodologies;design;Detection;Development;Devices;Diagnosis;digital;digital health;digital phenotyping;Disparity;Early Diagnosis;Early identification;Education;Engineering;Ethnic Origin;Facial Expression;Family;follow-up;girls;Goals;health care settings;Health Services Accessibility;Hispanic;Home;Human;implementation science;improved;Income;innovation;iterative design;Joints;Knowledge;Latino;literacy;Machine Learning;Measures;Methods;Modified Checklist for Autism in Toddlers;Monitor;Motor Skills;movie;Musculoskeletal Equilibrium;Names;novel;Nursery Schools;Outcome;Outcome Measure;Parent-Child Relations;Parents;Participant;Patient Recruitments;Pattern;pediatrician;Performance;Phenotype;Population;Population Heterogeneity;Predictive Value;Predictive Value of Tests;Primary Care;primary care clinic;primary care provider;Process;programs;prototype;Questionnaires;Race;recruit;remote administration;remote delivery;Research;response;Sampling;School-Age Population;screening;Screening procedure;Services;sex;social attention;Specificity;standard of care;Standardization;Tablets;Testing;Toddler;tool;usability;Video Recording;Videotape;Work

PROJECT_TITLE: A digital health approach to early identification and outcome monitoring in autism


NIH_SPENDING_CATS: Aging;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Estrogen;HIV/AIDS;Infectious Diseases;Menopause;Osteoporosis;Prevention;Women's Health Research

PHR: Project Narrative Women with HIV experience more frequent and severe menopause symptoms such as hot flashes and are at higher risk for the complications of reproductive aging such as neurocognitive impairment, bone loss, and heart disease. Hormone therapy can alleviate menopause symptoms but has not been studied in women with HIV. Using the infrastructure of the AIDS Clinical Trials Group, we propose to examine whether hormone therapy can effectively treat symptoms and minimize key aging-related comorbidities of menopause.

PI_NAMEs: BARES, SARA HURTADO;YIN, MICHAEL T (contact)

PROGRAM_OFFICER_NAME: SAZONOVA, IRINA Y

PROJECT_TERMS: Acceleration;Aging;aging related;AIDS clinical trial group;Anti-Inflammatory Agents;antiretroviral therapy;Biological Assay;Biological Markers;Biometry;bone;bone loss;bone turnover;cancer risk;cardiometabolism;Cardiovascular Diseases;cardiovascular risk factor;Caring;Cell Communication;Chronic;comorbidity;Cross-Over Trials;Data;design;Detection;Development;Disproportionately impacts women;Double-Blind Method;Down-Regulation;effective therapy;efficacy evaluation;Eligibility Determination;Endocrinology;endothelial dysfunction;Estrogen Therapy;Estrogens;experience;Experimental Models;Fracture;Future;Genetic Transcription;Goals;Gynecology;Health;Heart Diseases;high risk;HIV;HIV-1;Hormonal Change;hormone therapy;Hot flushes;immune activation;Immunology;Impaired cognition;improved;Inflammation;Infrastructure;innovation;interest;Life Expectancy;Measures;Mediating;Medicine;menopausal hormone therapy;Menopausal Symptom;Menopausal Syndrome;Menopause;Mental Health;monocyte;Moods;multidisciplinary;Neurocognition;Neurocognitive;Neurocognitive Deficit;neurocognitive disorder;Night Sweating;older women;Oral;Osteoporosis;Outcome;Pathway interactions;Perimenopause;Persons;Placebo Control;Placebos;Postmenopause;prevent;Prevention;Process;Progesterone;Property;prospective;Psychology;Quality of life;Randomized;reproductive senescence;Research;Research Personnel;Residual state;Resources;Risk;RNA;Role;Sleep;symptom treatment;Symptoms;systemic inflammatory response;therapy adherence;transdermal estrogen;treatment response;vasomotor symptoms;virology;Virus;Visit;Woman;Women's Health;Women's study

PROJECT_TITLE: Hormone Therapy for Peri- and Postmenopausal Women with HIV (HoT)

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Brain Disorders;Clinical Research;Data Science;Health Services;Intellectual and Developmental Disabilities (IDD);Machine Learning and Artificial Intelligence;Mental Health;Neurosciences;Pediatric;Prevention;Primary Health Care;Telehealth

PI_NAMEs: GOLDSTEIN, BENJAMIN ALAN (contact)

PROJECT_TERMS: 1 year old;6 year old;Academy;Address;Age;Age Months;American;Attitude;Autism Diagnosis;autism spectrum disorder;autistic children;behavioral outcome;Biological Markers;biomarker discovery;Birth;Blue Cross;Blue Shield;brain based;Caregivers;Caring;Child;Childhood;Clinical;clinical care;clinical decision support;Clinical Trials;Collaborations;Computing Methodologies;Data;Data Collection;Data Science;demographics;design;Development;Diagnosis;Diagnostic;digital health;Early identification;Early Intervention;early screening;Electronic Health Record;Environment;Evaluation;follow-up;Future;Gastroenterologist;gastrointestinal;Goals;Health;health care settings;health data;Health system;Human;implementation science;improved;improved outcome;Infant;innovation;iterative design;Learning;Life;Machine Learning;Medicaid;Medical;Methods;model of autism spectrum disorder;Modeling;Modified Checklist for Autism in Toddlers;Monitor;Natural Language Processing;Nature;Neurologist;North Carolina;novel;Ophthalmologist;Outcome;Outcome Measure;Participant;Pattern;Pediatrics;Positioning Attribute;predictive modeling;predictive tools;Predictive Value;Prevalence;Primary Care;primary care setting;Process;prototype;Provider;Public Health;Questionnaires;Recommendation;Research;routine care;Sampling;screening;Screening procedure;Services;sex;support tools;Testing;Toddler;tool;Universities;usability;Visit;Work

PROJECT_TITLE: Leveraging routinely collected health data to improve early identification of autism and co-occurring conditions


ORG_CITY: Aurora

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Development of novel therapeutics targeting HCN channels is hindered by a lack of information about allosteric and isoform-specific regulators. The long term goals of this project are to identify naturally-occurring, regulators of HCN channels and to understand their mechanisms of action. Achieving these goals will advance understanding of the physiological and molecular functions of HCN channels and aid in the development of new HCN channel drugs.

PI_NAMEs: PROENZA, CATHERINE  (contact)

PROGRAM_OFFICER_NAME: JUSTINOVA, ZUZANA

PROJECT_TERMS: Affinity;Binding;Biophysical Process;Bladder;Cardiac;Cell Physiology;cell type;Cells;Characteristics;Chemosensitization;Closure by clamp;Co-Immunoprecipitations;Colon;Coupling;Cyclic AMP;Cyclic Nucleotides;Cytoplasmic Tail;Data;Dependence;Detection;Development;Drug Targeting;Electrophysiology (science);Epilepsy;experimental study;FDA approved;Fluorescence;Future;gain of function;gastrointestinal;Goals;Guanylate kinase;HCN1 gene;HCN4 gene;Heart failure;improved;inhibitor;innovation;inorganic phosphate;Inositol;insight;Integral Membrane Protein;Interstitial Cell of Cajal;ivabradine;loss of function;Lymphoid;Measures;Membrane;Membrane Potentials;Membrane Proteins;Mental Depression;Modeling;Molecular;Molecular Conformation;Molecular Sieve Chromatography;motility disorder;Muscle Cells;Neurogenic Bladder;Neurons;new therapeutic target;nodal myocyte;novel;novel therapeutics;Pacemakers;painful neuropathy;patch clamp;Peripheral;Pharmaceutical Preparations;Physiological;Physiology;Property;Protein Isoforms;Proteins;Regulation;Role;Sensory;Signal Pathway;Sinoatrial Node;Site;Specificity;Substrate Interaction;System;targeted treatment;Testing;voltage;voltage gated channel

PROJECT_TITLE: Allosteric Modulation of HCN Channels


NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Intellectual and Developmental Disabilities (IDD);Machine Learning and Artificial Intelligence;Mental Health;Neurosciences;Pediatric;Prevention

PI_NAMEs: CARPENTER, KIMBERLY L H (contact)

PROJECT_TERMS: 6 year old;Address;Age;Attention;autism biomarker;autism spectrum disorder;autistic;autistic children;Behavior;behavioral outcome;behavioral response;Biological;Biological Markers;biomarker discovery;biomarker performance;Brain;brain based;Caregivers;Child;Child Behavior;Clinical;Clinical Trials;Code;Computer Vision Systems;Computing Methodologies;data acquisition;design;Development;Devices;digital health;digital phenotyping;Discrimination;Early identification;Early Intervention;Electroencephalography;Event-Related Potentials;Exclusion;Exhibits;Face;Facial Expression;Factor Analysis;Female;gaze;Goals;Heterogeneity;improved;improved outcome;indexing;Individual;innovation;Intellectual functioning disability;Machine Learning;machine learning method;Measurement;Measures;Methods;Monitor;multimodality;neural;neurophysiology;novel;Nursery Schools;Outcome;Outcome Measure;Participant;Pathway Analysis;Performance;Phase;Quality of life;Reporting;Research;response;Rest;Sampling;School-Age Population;screening;Screening procedure;sex;Sex Differences;social;social attention;Social Functioning;Source;Standardization;Stimulus;Stratification;Subgroup;Tablets;Technology;Testing;tool;Variant;Visual evoked cortical potential;visual tracking

PROJECT_TITLE: A machine learning computational approach for developing synchronized EEG and behavior biomarkers in young autistic children


NIH_SPENDING_CATS: Neurosciences;Physical Injury - Accidents and Adverse Effects;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_CITY: La Jolla

ORG_NAME: SALK INSTITUTE FOR BIOLOGICAL STUDIES

PHR: Project Narrative: The spinal cord contains local circuitry that drives coordinated patterns of motor pool activity to produce motor behaviors. In this grant the investigators will identify the cellular constituents of this circuitry, characterize the wiring diagram, and study how the neural circuitry arises. These experiments could provide new insight to understand how to overcome spinal cord injuries using motor learning and targeted stimulation to enhance the function of these neural pathways.

PI_NAMEs: PFAFF, SAMUEL L. (contact)

PROGRAM_OFFICER_NAME: CHEN, DAOFEN

PROJECT_TERMS: 3-Dimensional;Ablation;Address;Adopted;Afferent Neurons;Amphibia;Architecture;Atlases;Biological Assay;cell type;Cells;Complex;Computer Systems;conditional knockout;design;Development;Elements;Embryo;Embryonic Development;experience;experimental study;Feedback;Foundations;Freedom;Genetic;Goals;Grant;Heterogeneity;Hindlimb;Histologic;improved;Individual;insight;Interneurons;Joints;Knock-out;Knockout Mice;Label;Laboratories;laboratory experiment;Life;Link;Lumbar spinal cord structure;Maps;Mediating;Methods;Molecular;molecular marker;molecular subtypes;Motor;Motor Activity;motor behavior;motor control;motor learning;mouse genetics;Movement;Muscle;Muscle Contraction;neural;neural circuit;Neural Pathways;neuron development;neuronal patterning;Neurons;Neurophysiology - biologic function;neuroregulation;Nodal;optogenetics;Output;Pathway interactions;Pattern;Physical therapy;Physiological;Population;Positioning Attribute;postnatal;Primates;programs;Property;Proprioceptor;Recovery;Reflex action;Research;Research Personnel;Rodent;Role;Sensory;sensory feedback;Shapes;Signal Transduction;single-cell RNA sequencing;Specificity;Spinal;Spinal Cord;Spinal cord injury;Spinal cord injury patients;Spine pain;Stains;Stream;Synapses;synergism;System;Testing;Time;Touch sensation;transcription factor;Viral

PROJECT_TITLE: Characterization of spinal circuits underlying motor synergy function

STUDY_SECTION: SMN

STUDY_SECTION_NAME: Sensory-Motor Neuroscience Study Section[SMN]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Mental Health;Mental Illness;Neurosciences;Pediatric;Serious Mental Illness

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative Depression begins in adolescence, occurs at high rates, and is related to impaired functioning and suicide. Understanding the mechanisms of depression in the developing brain will improve our ability to prevent and treat this pernicious disorder. To investigate the role of the dopamine system, which is altered in depression and contributes to many features of depression, we will measure brain structure and function, dopamine function, inflammation, reward-driven behavior, and smartphone-based real-life experience and behavior, contributing to understanding how depression develops across adolescence and young adulthood.

PI_NAMEs: FORBES, ERIKA E (contact)

PROGRAM_OFFICER_NAME: MURPHY, ERIC ROUSSEAU

PROJECT_TERMS: Acceleration;Adolescence;Adolescent;Age;Anhedonia;Basal Ganglia;Behavior;Behavioral;Brain;Cellular Phone;child depression;Clinical;Corpus striatum structure;depressive symptoms;Development;disability;Disease;Dopamine;dopamine system;Ecological momentary assessment;Exhibits;experience;Functional disorder;Functional Magnetic Resonance Imaging;Future;hedonic;Impairment;improved;Inflammation;inflammatory marker;interest;Interleukin-6;Iron;Life;Life Experience;Link;longitudinal design;Magnetic Resonance Imaging;Measurement;Measures;Medial;Mediating;Mental Depression;Methods;Midbrain structure;motivated behavior;Motivation;Motor;Motor Activity;neural circuit;neurobehavioral;neuroinflammation;neuromelanin;neuroregulation;Neurosciences;Nucleus Accumbens;Pathway interactions;Pattern;Peripheral;phenomenological models;Prefrontal Cortex;presynaptic;prevent;Psychopathology;rate of change;response;Rest;reward anticipation;reward circuitry;Rewards;Role;self-reported depression;sensor;Severities;Structure;Substantia nigra structure;Suicide;Support System;System;Telephone;Testing;Text;Text Messaging;Time;Tissues;TNF gene;translational approach;Ventral Striatum;Vesicle;young adult

PROJECT_TITLE: Dopamine Availability and Developmental Pathways of Adolescent Depression and Anhedonia

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Lung;Physical Activity;Prevention;Pulmonary Hypertension;Rare Diseases

PHR: Project Narrative Pulmonary arterial hypertension (PAH) is characterized by limitation of physical activity. We will monitor physical activity in a large population of PAH patients in the United States to determine if certain types of activity are particularly beneficial. The results of this study could change how we monitor patients with PAH and how we study new therapies.

PI_NAMEs: KAWUT, STEVEN M (contact)

PROGRAM_OFFICER_NAME: XIAO, LEI

PROJECT_TERMS: Accelerometer;Address;Adult;adverse event risk;Age;Ancillary Study;Biosensor;Blood Vessels;Cardiac;Cardiopulmonary;Caring;Cessation of life;Childhood;Clinical;Clinical assessments;clinical care;Clinical Trials;cohort;Data;data streams;Defect;design;Dimensions;Disease;Educational Status;Emergency department visit;emotional factor;Endothelium;Enrollment;Environmental Risk Factor;Epoprostenol;evidence base;Exercise;exercise capacity;exercise intervention;fitness;follow-up;Frequencies;health related quality of life;high risk;Hospitalization;Hour;human old age (65+);improved;indexing;Individual;innovation;insight;instrument;Intravenous;Life;Lung;Lung Transplantation;Measures;Medical;Monitor;Muscle;novel;novel therapeutics;Observational Study;Outcome Study;Outpatients;Patient Monitoring;patient oriented;patient registry;Patients;Pattern;Peripheral;Personal Satisfaction;Persons;Phenotype;Physical activity;physical model;Pilot Projects;Population;Principal Component Analysis;Proliferating;prospective;psychosocial;Publishing;pulmonary arterial hypertension;Pulmonary Hypertension;Pump;Quality of life;randomized, clinical trials;Registries;residence;right ventricular failure;sedentary;Severities;sex;SF-12;side effect;Smooth Muscle Myocytes;socioeconomics;supplemental oxygen;Symptoms;System;Systemic disease;Testing;Time;treatment effect;United States;vascular bed;Walking;wearable sensor technology

PROJECT_TITLE: Physical Activity in Pulmonary Arterial Hypertension (ACTiPH)

STUDY_SECTION: CHSA

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology A Study Section[CHSA]


NIH_SPENDING_CATS: Cardiovascular;Heart Disease

PHR: Project Narrative This study will reveal the binding of PIP2 and CaM to the IKs channel protein, which is important in controlling heart rhythm, and subsequent conformational changes that open the channel. These results will provide a molecular basis to understand how heart rhythm is regulated by cell signals and multiple mechanisms for drugs to target and modify, which may lead to the development of more effective and safe antiarrhythmic drugs.

PI_NAMEs: CUI, JIANMIN  (contact)

PROGRAM_OFFICER_NAME: SHI, YANG

PROJECT_TERMS: Action Potentials;Anti-Arrhythmia Agents;Arrhythmia;Binding;Binding Sites;Calmodulin;Cardiac;Cardiac Electrophysiologic Techniques;Cartoons;Cell Line;Cells;cofactor;Complex;Coupling;Cryoelectron Microscopy;Data;design;Development;drug development;Electrophysiology (science);experimental study;Family member;Fluorescence Resonance Energy Transfer;Fluorescence Spectroscopy;fluorophore;Goals;Heart;heart rhythm;Human;improved;Interruption;Lead;Left;Lobe;Mammalian Cell;Mediating;Membrane;Membrane Lipids;Molecular;Molecular Conformation;molecular dynamics;Motion;Mutagenesis;Mutate;novel;Oranges;Pharmaceutical Preparations;Phosphatidylinositol 4,5-Diphosphate;Phosphatidylinositols;Physiological;Play;Potassium Channel;prevent;Process;Proteins;Publishing;Rest;Role;sensor;Signal Transduction;Site;Structure;Surface;Testing;trafficking;voltage;Xenopus oocyte

PROJECT_TITLE: Gating Mechanisms of KCNQ1/IKS Channels


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Digestive Diseases;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hepatitis;Hepatitis - C;Infectious Diseases;Kidney Disease;Liver Disease;Opioid Misuse and Addiction;Opioids;Prevention;Primary Health Care;Social Determinants of Health;Substance Misuse

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative This is a resubmission of a competing renewal proposal for a midcareer investigator award in patient-oriented research for Gregory Lucas, Professor at the Johns Hopkins School of Medicine. Dr. Lucas conducts research addressing barriers to HIV prevention and treatment and medical comorbidity in populations of people who inject drugs. The objectives of this proposal are to support a program for mentoring junior investigators and to foster innovative epidemiologic and implementation research targeting underserved populations.

PI_NAMEs: LUCAS, GREGORY M (contact)

PROGRAM_OFFICER_NAME: WEBB, CANDACE KARONDELETTE

PROJECT_TERMS: Address;Affect;AIDS prevention;antiretroviral therapy;Attention;Baltimore;Cardiovascular Diseases;career development;Caring;Cities;Clinic;clinical investigation;Clinical Management;Clinical Trials;Cluster randomized trial;cocaine use;cofactor;cohort;Cohort Studies;Collaborations;Communicable Diseases;Communities;comorbidity;Creatinine;Data;design;Doctor of Philosophy;Drug usage;effectiveness evaluation;Environment;Epidemic;Epidemiology;epidemiology study;Evaluation;evidence base;experience;follow-up;Fostering;Funding;Glomerular Filtration Rate;Goals;Health;Hepatitis C virus;HIV;HIV Seropositivity;HIV/HCV;implementation research;improved;improved outcome;Incentives;Individual;Injecting drug user;injection drug use;innovation;integrated care;Interdisciplinary Study;International;Intervention;Iohexol;Kidney Diseases;Leadership;Link;marginalized population;Measurement;Measures;Medical;medical schools;medication-assisted treatment;Medicine;member;men who have sex with men;Mentors;Methods;Midcareer Investigator Award in Patient-Oriented Research;Naloxone;Needle-Exchange Programs;Nose;opioid epidemic;opioid overdose;Outcome Study;overdose death;Ownership;Parents;Participant;Patients;Penetration;Persons;Pharmaceutical Preparations;Population;post gamma-globulins;pre-exposure prophylaxis;predictive modeling;prevention service;Productivity;professor;programs;Protocols documentation;Public Health Schools;randomized trial;recruit;Research;Research Personnel;Resources;Respondent;response;Role;Sampling;Serum;Services;Specialist;standard care;standard measure;Surveys;Targeted Research;tool;Training;Treatment outcome;treatment services;Underserved Population;Universities;Viral;Visit;Work

PROJECT_TITLE: Treatment outcomes and comorbidity in HIV-infected IDU

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


ORG_CITY: DALLAS

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: PROJECT NARRATIVE We propose to significantly advance the in vivo cancer imaging capability of our small animal radiation research platform (SARRP) to include quantitative bioluminescence and fluorescence tomography. The novel optical imaging system is expected to enhance pre-clinical radiation guidance and assessment for anatomical and functional targets. The dissemination of the functional imaging SARRP platform is particularly important at the present time when radiation is being tested not only for its efficacy as a local control agent but also as an effective modulator for immunotherapy and other biologic therapeutics.

PI_NAMEs: WANG, KEN KANG-HSIN  (contact)

PROGRAM_OFFICER_NAME: OBCEMEA, CEFERINO H

PROJECT_TERMS: 3-Dimensional;Address;Adopted;Adoption;Algorithms;Anatomy;Animals;anti-tumor immune response;Biological;Biological Response Modifier Therapy;Biology;Bioluminescence;bioluminescence imaging;Biomedical Engineering;cancer imaging;clinical translation;commercialization;Complement;cone-beam computed tomography;contrast imaging;Data;Data Analyses;design and construction;Docking;Engineering;Environment;Epidermal Growth Factor Receptor;Equation;Excision;Fluorescence;fluorescence imaging;Fluorescent Probes;fluorophore;Functional Imaging;Glioblastoma;Heterogeneity;Human;Hypoxia;imaging capabilities;imaging study;imaging system;Immunotherapy;improved;in vivo;in vivo evaluation;in vivo Model;Industrialization;industry partner;irradiation;Knowledge;Lasers;Light;Measures;metabolic rate;Methods;Modeling;Modernization;Molecular;multidisciplinary;Normal tissue morphology;novel;optical imaging;Optical Tomography;Optics;Performance;Positioning Attribute;Positron-Emission Tomography;pre-clinical;pre-clinical assessment;pre-clinical research;Property;Radiation;radiation response;Radiation therapy;reconstruction;Research;Research Personnel;response;Roentgen Rays;Rotation;Sensitivity and Specificity;serial imaging;Shapes;Signal Transduction;soft tissue;Source;Specific qualifier value;spectrograph;success;System;Technology;Testing;Therapeutic;therapy design;Time;Tissues;tomography;treatment research;tumor;Tumor Tissue;Uncertainty;X-Ray Computed Tomography

PROJECT_TITLE: X-ray/optical tomographic guidance and assessment for pre-clinical radiation Research


NIH_SPENDING_CATS: Brain Disorders;Drug Abuse (NIDA only);Genetics;Human Genome;Substance Misuse

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE Human and model organism research has generated oceans of genetic and genomic data that can provide insights into the neurobiological mechanisms of addiction. However, we lack the tools to integrate these data across species, which is hindering our ability to make actionable breakthroughs. This project will develop a toolkit for making cross-species integration a routine task; such framework should enable a follow-up of genetic association results with multi-omics investigations of molecular mechanisms, to facilitate their clinical translation and improve diagnosis, monitoring and treatment of addiction.

PI_NAMEs: SANCHEZ ROIGE, SANDRA  (contact)

PROGRAM_OFFICER_NAME: POLLOCK, JONATHAN D

PROJECT_TERMS: addiction;Affect;Alcohols;Animal Model;Architecture;Cannabis;Catalogs;clinical translation;Data;data integration;Data Set;Development;Diagnosis;disability;drug repurposing;follow-up;Functional disorder;Gene Expression;Genes;Genetic;genetic association;genetic signature;Genetic study;genetic variant;genome wide association study;genomic data;genomic locus;genomic variation;Genotype;Genotype-Tissue Expression Project;Human;Human Genetics;Human Genome;improved;Individual;innovation;insight;Intervention;Investigation;Mental disorders;Methodology;Methods;model organism;Molecular;Monitor;multiple omics;Nature;Network-based;neurobiological mechanism;novel;novel therapeutics;Oceans;Opioid;Pathway Analysis;Phenotype;polygenic risk score;predictive modeling;Research;Resources;Risk;risk prediction;Rodent;Signal Transduction;small molecule;Substance Use Disorder;Sum;Techniques;Testing;Tobacco;tool;trait;Transcript;transcriptome;transcriptomics;Translating;translational genetics;Translations

PROJECT_TITLE: Building Bridges to Allow Cross-species Translational genetics for the Study of Addiction


ED_INST_TYPE: GRADUATE SCHOOLS

ORG_DEPT: BIOLOGY

ORG_NAME: ROCKEFELLER UNIVERSITY

PHR: Project Narrative The MetNet Center for Systems-level Study of Metastasis will elucidate how dynamic interactions between neuronal cells, localized lymphatics, metabolites and cancer cells collectively contribute to the emergence of metastatic disease—thereby identifying critical genes as therapeutic targets for its eradication.

PI_NAMEs: TAVAZOIE, SOHAIL F. (contact)

PROGRAM_OFFICER_NAME: GRIL, BRUNILDE M

PROJECT_TERMS: analytical method;Automobile Driving;Bioinformatics;Biological;biological systems;Biology;Breast Cancer Cell;cancer cell;cancer therapy;Cell Communication;Cell Physiology;cell type;Cells;chemotherapy;Clinic;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Colorectal Cancer;colorectal cancer metastasis;Colorectal Neoplasms;Complex;Computer Analysis;Computing Methodologies;Development;Disease;Dissection;Endothelial Cells;Epidemiology;Event;experience;Gene Expression;Generations;Genes;Genetic;Goals;Grant;Image;Immune;Immunity;innovation;insight;Knowledge;Lymphatic;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Neoplasms;Medical Oncology;Memorial Sloan-Kettering Cancer Center;Metabolic;Metabolite Interaction;Methods;Molecular;multidisciplinary;Neoplasm Metastasis;nerve supply;Nervous System;neural;Neuroepithelial;Neuroimmune;Neurons;neurotransmission;novel;Nutrient;Phase;Phenotype;Physicians;Positioning Attribute;prevent;Primary Neoplasm;Process;programs;Property;Research Personnel;response;RNA-Binding Proteins;Role;Scientist;Series;Shapes;Signal Transduction;Signaling Protein;single cell sequencing;Site;success;System;Systems Biology;Technical Expertise;Technology;therapeutic target;tool;transcription factor;treatment response;tumor;tumor immunology;tumor metabolism;tumor progression


PROJECT_TERMS: Administrator;Advisory Committees;Annual Reports;Calendar;career development;Cells;Collaborations;Communication;Communities;Core Facility;Data;Expenditure;Funding;Future;Goals;Institution;Leadership;Link;Logistics;meetings;Memorial Sloan-Kettering Cancer Center;Mouse Cell Line;Neoplasm Metastasis;Occupational activity of managing finances;Office of Administrative Management;Organization administrative structures;outreach;Pathologist;Physicians;Pilot Projects;Preparation;Progress Reports;Protocols documentation;Publications;Reagent;Reporting;Research;Research Personnel;Research Project Grants;Resource Allocation;Resources;Schedule;Scientist;single cell sequencing;Structure;System;tumor;United States National Institutes of Health;Universities;Update;web site

PROJECT_TITLE: Center Administration Core


NIH_SPENDING_CATS: Autism;Brain Disorders;Clinical Research;Disability Research;Intellectual and Developmental Disabilities (IDD);Maternal Health;Mental Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Women's Health Research

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: PROJECT NARRATIVE We will study 1.2 million children to test autism risk associated with prenatal exposure to medications, examine the diverse sources of confounding in these associations, and test the findings’ generalizability and specificity. As majority of medications taken by pregnant women has not been studied in the context of autism risk, our medication-wide approach will close an important knowledge gap regarding potentially modifiable risk factors for the disorder. Our goal is to pave the way for advancing autism prevention and treatment, identify of high-risk subgroups and critical risk pathways, and further enhance our understanding of autism etiology.

PI_NAMEs: JANECKA, MAGDALENA ;REICHENBERG, ABRAHAM  (contact);SCHLESSINGER, AVNER

PROGRAM_OFFICER_NAME: OREILLY, JULIA JIAQI

PROJECT_TERMS: Accounting;Address;Affect;Attention deficit hyperactivity disorder;autism spectrum disorder;Benchmarking;Biometry;Cerebral Palsy;Chemical Structure;Child;Childhood Asthma;Clinical;Collaborations;Combination Medication;congenital heart abnormality;Data;delivery complications;Demographic Factors;design;Development;Developmental Disabilities;Dimensions;Disease;disorder risk;Drug Kinetics;Environmental Risk Factor;Epidemiology;Etiology;Exposure to;Family;fetal;Fetus;Finland;Genetic;genetic pedigree;Goals;Health;health data;high risk;Incidence;Individual;innovation;insight;Intellectual functioning disability;Israel;Knowledge;Link;Live Birth;Maternal Age;Maternal Exposure;Maternal Health;Medical;Methods;modifiable risk;Mothers;novel;offspring;Outcome;Paternal Exposure;Pathway interactions;Pharmaceutical Preparations;pharmacologic;Pharmacology;Pharmacotherapy;Placenta;Polypharmacy;population based;Pregnancy;Pregnant Women;Premature Birth;prenatal;prenatal exposure;Prevalence;Prevention;Prevention strategy;Property;Prospective cohort;Proxy;Psychiatric epidemiology;Public Health;Registries;response;Risk;Risk Factors;Role;Sampling;sex;Siblings;Source;Specificity;Structure;Subgroup;Sweden;System;Testing;Time;trend

PROJECT_TITLE: Prenatal medication exposure in autism, birth complications and developmental disabilities

STUDY_SECTION: NAME

STUDY_SECTION_NAME: Neurological, Aging and Musculoskeletal Epidemiology Study Section[NAME]


NIH_SPENDING_CATS: Cancer;Clinical Research

ORG_CITY: NOTRE DAME

ORG_NAME: UNIVERSITY OF NOTRE DAME

ORG_STATE: IN

PHR: Adapting a point of use test card, the chemoPAD, for protecting chemotherapy drug quality in sub-Saharan Africa Project Narrative Many low- and middle-income countries don’t have the resources to test the quality of chemotherapy drugs, even though bad quality or fake chemotherapy medicines can cause cancer treatments to fail. This project will create inexpensive test cards and a free phone app to detect bad quality chemotherapy medicines at the point of use in hospitals and cancer clinics. Our team of scientists, oncology pharmacists, doctors, supply chain experts, and drug regulators in Ethiopia, Malawi, Kenya, and Cameroon will test the technology to make sure it can detect bad quality chemotherapy drugs before the drugs are given to patients. 1

PI_NAMEs: LIEBERMAN, MARYA  (contact)

PROGRAM_OFFICER_NAME: DIVI, RAO L

PROJECT_TERMS: Address;Africa South of the Sahara;Awareness;Biological Assay;Cameroon;Cancer Etiology;cancer therapy;chemotherapy;Clinic;Clinical;Clinics and Hospitals;Cold Chains;cost-effectiveness evaluation;Country;Data;Development Plans;Drops;drug quality;Drug Screening;Educational workshop;empowerment;Ethics;Ethiopia;Goals;Health;High Pressure Liquid Chromatography;Hospitals;Image;improved;Injectable;Kenya;Left;low and middle-income countries;Malawi;Malignant Neoplasms;manufacture;Manufacturer;Marketing;Medicine;Methods;Modeling;Motivation;multidisciplinary;Needs Assessment;neural network;new technology;North Carolina;Nurses;Oncology;outreach;Paper;Participant;Patients;Performance;Pharmaceutical Preparations;Pharmacists;Pharmacologic Substance;Phase;Pilot Projects;Play;post-market;Privatization;programs;Protocols documentation;Reporting;Research Personnel;Resource-limited setting;Resources;Sampling;Scientist;screening;Screening Result;Site;smartphone application;supply chain;Surveys;symposium;System;Technology;Technology Transfer;Telephone;Testing;therapy outcome;Training;Validation;validation studies;Vertebral column;Vial device;Work


NIH_SPENDING_CATS: Breast Cancer;Cancer;Neurosciences;Women's Health Research

PROJECT_TERMS: 3-Dimensional;Address;Affect;Automobile Driving;axon guidance;Binding;Biochemical;Blood Vessels;breast cancer metastasis;breast cancer progression;cancer cell;Cell Line;Cells;Coculture Techniques;Complex;Computing Methodologies;Denervation;Dependence;Disease;Disseminated Malignant Neoplasm;Distant;Endothelial Cells;Endothelium;experimental study;Extracellular Matrix Proteins;Genetic;Goals;Image;imaging study;Immune;Immune system;Immunofluorescence Immunologic;Impairment;in vivo;Infiltration;Interdisciplinary Study;Invaded;Label;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant Neoplasms;malignant stomach neoplasm;Mammary Neoplasms;Mechanics;Mediating;migration;Molecular;Molecular Probes;Nature;Neoplasm Metastasis;Nerve;nerve supply;neural;neural model;Neurobiology;Neuroepithelial, Perineurial, and Schwann Cell Neoplasm;Neurons;neuroregulation;neurotransmission;neurotrophic factor;new therapeutic target;Nonmetastatic;Nutrient;Oxygen;Pattern;perineural;Peripheral;pharmacologic;Phenotype;Play;Population;Process;Proliferating;Proteins;Recurrence;Research;Resistance;response;Risk;RNA-Binding Proteins;Role;Signal Transduction;single cell sequencing;Skin Cancer;System;Testing;therapeutic target;therapy resistant;transcription factor;tumor;Tumor Cell Invasion;tumor initiation;tumor microenvironment;tumor progression;Tumor Promotion;Tumor-infiltrating immune cells;tumorigenesis;Work

PROJECT_TITLE: Project-1: Defining the mechanisms by which neurons promote breast cancer metastasis


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Colorectal Cancer;Digestive Diseases;Genetics;Human Genome;Liver Disease;Lymphatic Research;Neurosciences;Prevention

PI_NAMEs: MUCIDA, DANIEL S (contact)

PROJECT_TERMS: adaptive immunity;Address;Affect;Antigens;Antitumor Response;Architecture;Bioinformatics;Biology;Cell Communication;cell injury;cell killing;Cell Separation;Cells;Cellular Metabolic Process;Collection;Colorectal Cancer;colorectal cancer metastasis;colorectal cancer prevention;colorectal cancer progression;Communication;Critical Pathways;Cues;cytokine;Data;Diet;Distal;Drainage procedure;draining lymph node;Early identification;Enteral;enteric pathogen;Environment;Epithelial Cells;Equilibrium;Event;Food Hypersensitivity;gain of function;Gastrointestinal tract structure;Gene Expression Profile;Genetic;genetic approach;Gnotobiotic;Image;imaging approach;Imaging Techniques;Immune;Immune response;Immune system;Immunologic Surveillance;Immunologics;In Vitro;Indigenous;Inflammation;Inflammatory;Inflammatory Bowel Diseases;Intestinal Neoplasms;intestinal villi;Intestines;Invaded;Irritable Bowel Syndrome;Label;Liver;Location;loss of function;Lymph Node Drainage;lymph nodes;Lymphatic;lymphatic drainage;Lymphatic System;lymphatic vessel;Malignant Neoplasms;Maps;Mediating;metabolomics;metastatic colorectal;Metastatic Neoplasm to the Liver;microbial;microbiota;Modernization;Molecular;mouse model;Mucous Membrane;Neoplasm Metastasis;Neuroimmune;neuronal cell body;neuronal circuitry;Neurons;novel;novel strategies;Patients;Persons;Physiology;Play;Population;prevent;Primary Neoplasm;Resistance;response;Role;Route;screening;Signal Transduction;Site;Submucosa;System;Tissues;tool;transcriptomics;Translating;translatome;tumor;Tumor Immunity;tumor microenvironment;tumor progression;United States;Visualization

PROJECT_TITLE: Project-2:Defining the role of compartmentalized neuro-lymphatic networks on CRC and metastatic progression


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Digestive Diseases;Esophageal Cancer;Genetics;Human Genome;Microbiome;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE Deaths from cancers arising from the gastro-esophageal junction represent a major public health burden, yet the factors that drive early changes in this region remain poorly understood. We aim to gain a clearer understanding of the effects of secondary bile acids produced by bacteria in the gut on stem cells in gastro-esophageal region. This knowledge can in turn be translated to future efforts to target the gut microbiome to prevent gastro- esophageal cancer.

PI_NAMEs: ABRAMS, JULIAN  (contact);QUANTE, MICHAEL ;WANG, HARRIS H

PROGRAM_OFFICER_NAME: YASSIN, RIHAB R

PROJECT_TERMS: Acceleration;Acids;Address;Adenocarcinoma;Affect;Agonist;antagonist;Area;Barrett Esophagus;Bile Acids;carcinogenesis;Cell Count;Cells;Cessation of life;chemokine;clinically significant;cohort;Collaborations;Data;Deoxycholic Acid;Development;Distal;Dysplasia;Epithelial Attachment;epithelial stem cell;Esophageal Adenocarcinoma;Esophagogastric Junction;Esophagus;experimental study;Future;gastroesophageal cancer;gut bacteria;gut microbiome;High Fat Diet;Human;Immune;Inflammasome;Inflammation;Inflammatory;Knock-out;Knowledge;LGR5 gene;Malignant Neoplasms;microbiome;microbiome composition;Modeling;Modification;Molecular;mortality;mouse model;multidisciplinary;Mus;Myeloid Cells;Natural Killer Cells;Neoplasms;neutrophil;new therapeutic target;novel;novel strategies;Nuclear;Organoids;Patients;Population;Precancerous Conditions;prevent;probiotic therapy;Production;Proliferating;Prospective Studies;prototype;Public Health;rational design;receptor;Regional Cancer;Risk Factors;Role;Sampling;Series;single-cell RNA sequencing;spatiotemporal;stem;stem cell fate;stem cells;Stomach;stomach cardia;Stromal Cells;Techniques;Translating;Validation;Work

PROJECT_TITLE: The Role of Secondary Bile Acids in Gastro-Esophageal Neoplasia


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Estrogen;Women's Health Research

ORG_CITY: ALBUQUERQUE

ORG_NAME: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR

ORG_STATE: NM

PHR: PROJECT NARRATIVE Drugs targeting estrogen receptors or estrogen production have been highly successful in the fight against breast cancer. However, it is now clear that these drugs are not as selective as once thought; drugs such as fulvestrant, raloxifene and tamoxifen, which inhibit classical estrogen receptors in breast cancer, stimulate the G protein-coupled estrogen receptor GPER, potentially resulting in hormone resistance and an increased risk of endometrial cancer. Resistance to aromatase inhibitors often results in continued sensitivity to estrogen receptor-targeted drugs. The goal of our research is to understand this complexity and develop a new generation of highly selective drugs that target only the classical estrogen receptors, avoiding side effects of many existing drugs.

PI_NAMEs: ARTERBURN, JEFFREY B;PROSSNITZ, ERIC R (contact)

PROGRAM_OFFICER_NAME: FU, YALI

PROJECT_TERMS: Address;Affinity;Agonist;Anabolism;analog;antagonist;anti-tumor agent;appendage;Aromatase Inhibitors;Binding;Biological;Biological Assay;Biology;Breast Cancer Cell;Cancer cell line;cancer clinical trial;cancer recurrence;Cell Line;Cell Proliferation;Cell Survival;Cells;Chemicals;Chemoresistance;Clinical;Clinical Trials;cross reactivity;Development;Diagnosis;Disease;Disseminated Malignant Neoplasm;Drug Targeting;enantiomer;Endometrial;Endometrial Carcinoma;ESR1 gene;Estrogen Antagonists;Estrogen Receptor 2;Estrogen receptor positive;Estrogen Receptors;estrogenic;Estrogens;Exhibits;experience;fighting;Fulvestrant;Funding;G-Protein-Coupled Receptors;Generations;Genomics;Goals;GPER gene;Growth;Hormonal;hormone resistance;hormone therapy;Hormones;Hyperplasia;improved;In Vitro;in vivo;Incidence;Individual;innovation;Lead;Letrozole;Ligands;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Neoplasms;Mediating;Membrane;Metabolic;Methods;Modeling;Modification;Molecular;Mus;Names;Nature;Neoplasm Metastasis;novel;Nuclear Hormone Receptors;Outcome;Pathway interactions;Patients;Performance;Pharmaceutical Preparations;pharmacologic;Phase I Clinical Trials;Physiological;Physiology;polyoma middle tumor antigen;Polyps;Prevention;Production;Proliferating;Property;Publishing;Quality of life;Raloxifene;RBM5 gene;receptor;receptor binding;Recurrence;refractory cancer;Reporter;Research;Resistance;Resistance development;Risk;scaffold;Selective Estrogen Receptor Modulators;Series;side effect;Signal Transduction;small molecule;Steroid Receptors;Steroids;Structure;Tamoxifen;Therapeutic Agents;Thromboembolism;Time;tool;Toxic effect;Transcriptional Regulation;transcriptome sequencing;Transgenic Organisms;translational potential;tumor;tumor xenograft;Uterus;Woman;women's treatment;Work;Xenograft procedure

PROJECT_TITLE: Molecular Mechanisms and Applications of Novel ER/GPER-selective Ligands

STUDY_SECTION: DMP

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology Study Section[DMP]


NIH_SPENDING_CATS: Bioengineering;Breast Cancer;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Nanotechnology;Women's Health Research

ORG_CITY: DENTON

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF NORTH TEXAS

PHR: Narrative: The proposed study will explore new therapeutic targets based on self-assembling peptides for developing treatments of Triple -negative breast cancer (TNBC). This project will contribute to treatments that could improve the outcome of drug resistance breast cancers.

PI_NAMEs: HABIBI, NEDA  (contact)

PROGRAM_OFFICER_NAME: BERNAL, FEDERICO

PROJECT_TERMS: Adult;Alkaline Phosphatase;Amino Acids;Apoptosis;Aromatase Inhibitors;Biochemical Reaction;Biological Assay;Breast Cancer Cell;Breast Cancer Patient;cancer cell;Cancer Cell Growth;cancer type;Cancerous;Cell Death;Cell Surface Receptors;Cells;cellular imaging;Cessation of life;chemotherapy;Data;design;Development;Disease;Dose;Drug resistance;Drug Targeting;effective therapy;efficacy evaluation;embryonic protein;Environment;enzyme activity;Enzyme Induction;Enzyme Kinetics;enzyme substrate;Enzymes;Epidermal Growth Factor Receptor;Estrogen Receptors;Exposure to;Eye;Growth;High Pressure Liquid Chromatography;hormone therapy;Human;Image;improved outcome;In Vitro;Inhibition of Cancer Cell Growth;inorganic phosphate;Location;Malignant Breast Neoplasm;MDA MB 231;Medicine;Molecular Target;nanofiber;Nanostructures;Nanotechnology;Napping;Necrosis;Neoplasm Metastasis;new therapeutic target;Normal Cell;novel;novel strategies;Organ;Pathway interactions;Patients;peptide drug;peptide structure;Peptides;Phase;Phosphoric Monoester Hydrolases;Phosphothreonine;Process;Progesterone Receptors;protein aminoacid sequence;Protein Dephosphorylation;Protein Tyrosine Phosphatase;Proteins;receptor;Receptor Cell;Relapse;Research;response;self assembly;small molecule;Solid;spheroids;Structure;Tamoxifen;Techniques;three dimensional cell culture;Time;Tissues;Trastuzumab;treatment response;triple-negative invasive breast carcinoma;tumor;Tyrosine;Western Blotting

PROJECT_TITLE: New approach based on enzyme stimulating of peptides for targeting drug resistance breast cancers


NIH_SPENDING_CATS: Breast Cancer;Cancer;Cancer Genomics;Genetics;Human Genome;Lung;Women's Health Research

ORG_CITY: NEW YORK

PI_NAMEs: BIRSOY, KIVANC  (contact)

PROJECT_TERMS: 4T1;Address;Affinity;Area;Breast;Breast Cancer Cell;breast cancer metastasis;cancer cell;cancer heterogeneity;Cancer Model;Cell Communication;cell type;Cells;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Colon Carcinoma;Computational Biology;CRISPR screen;CRISPR/Cas technology;Dependence;Distant;Environment;Enzymes;epigenome;experience;extracellular;gain of function;Gene Expression Profile;Genes;Genetic;genetic approach;Genetic Screening;Goals;in vivo;innovation;Knowledge;Liver;loss of function;Lung;lung colonization;Maps;MC38;Metabolic;Metabolic stress;Metabolism;metabolomics;Metastatic Neoplasm to the Liver;Metastatic Neoplasm to the Lung;Methods;Modeling;Molecular;multidisciplinary;multiphoton microscopy;multiple omics;Neoplasm Circulating Cells;Neoplasm Metastasis;neoplastic cell;Non-Malignant;Normal Cell;Nutrient;Nutrient availability;Organ;Organelles;Oxygen;Pathway interactions;photoactivation;Population;Process;programs;Repression;Role;single cell sequencing;Site;small molecule;Starvation;System;Techniques;Testing;Therapeutic;Tissues;transcriptome;transcriptomics;treatment response;tumor;Work

PROJECT_TITLE: Project 3: The role of microenvironmental metabolites on metastatic progression


NIH_SPENDING_CATS: Aging;Atherosclerosis;Biodefense and Related Countermeasures;Cardiovascular;Emerging Infectious Diseases;Heart Disease;Heart Disease - Coronary Heart Disease;Immunotherapy;Infectious Diseases;Influenza;Lung;Pneumonia and Influenza

ORG_DEPT: PEDIATRICS

PHR: Narrative Influenza-associated cardiovascular death is significant during rate influenza pandemics. Although there are numerous clinical reports about influenza-associated cardiovascular death, the pathogenesis underlying the development of cardiovascular disease is poorly understood. The goal of this study to understand the pathogenesis of influenza-associated exacerbation of atherosclerosis.

PI_NAMEs: GOPAL, RADHA  (contact)

PROGRAM_OFFICER_NAME: KIRBY, RUTH

PROJECT_TERMS: Acceleration;adaptive immune response;Antigen Presentation;Aorta;Apolipoprotein E;Arterial Fatty Streak;Arteries;Atherosclerosis;Blood Vessels;Body Weight decreased;Bone Marrow;bronchial epithelium;Cardiovascular Diseases;cardiovascular disorder risk;Cardiovascular system;Cause of Death;CCL2 gene;CCL3 gene;Cells;Cessation of life;chemokine;Clinical;Color;Complication;Coronary Arteriosclerosis;Critical Care;cytokine;cytokine release syndrome;Dendritic Cells;Development;Endothelial Cells;epidemiology study;Epithelial Cells;Epithelium;Event;flu;Foam Cells;Frequencies;Goals;Heart failure;High Fat Diet;Human;IL17 gene;Immune;Immunotherapeutic agent;In Vitro;Incidence;Infection;Inflammation Mediators;Inflammatory;Inflammatory Response;Influenza;Influenza A virus;influenza infection;influenzavirus;Innate Immune Response;insight;Interferon Type I;Interferon Type II;Interferons;Interleukin-6;intraperitoneal;Knowledge;Label;Laboratories;Lipids;Lung;Lung Diseases;Lymphoid;Macrophage;Morbidity - disease rate;mortality;mouse model;Mus;Myelogenous;Myocardial Infarction;Oropharyngeal;Outcome;oxidized low density lipoprotein;pandemic influenza;Pathogenesis;Pathologic;Patients;Phase;Play;Pneumonia;RANTES;Recovery;recruit;Reporting;Research;Risk;Role;Rupture;Series;Serum;Signal Transduction;Spleen;Stimulus;Stroke;T-Lymphocyte;Testing;therapeutic target;Time;trafficking;Vascular Endothelial Cell;Viral;Virus Replication;Weight Gain

PROJECT_TITLE: Immune mechanisms of influenzaÃ¢ÂÂinduced exacerbation of atherosclerosis

STUDY_SECTION: AICS

STUDY_SECTION_NAME: Atherosclerosis and Inflammation of the Cardiovascular System Study Section[AICS]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Building Research Capacity at Institutions with Limited NIH Funding;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: SACRAMENTO

ORG_NAME: CALIFORNIA STATE UNIVERSITY SACRAMENTO

PHR: PROJECT NARRATIVE: This project is focused on the development of two different types of carbohydrate-containing polymers as potential broad-spectrum anti-viral agents. If successful, these molecules could be used to shorten the length of time someone is symptomatic, and/or decrease the mortality rate associated with the viral infections, particularly those caused by pandemic-causing viruses like SARS-CoV-2 and HIV-1.

PI_NAMEs: MCREYNOLDS, KATHERINE D (contact)

PROJECT_TERMS: 2019-nCoV;Affect;Affinity;Alkynes;Anti-viral Agents;Architecture;Azides;Binding;Binding Proteins;Biological;Biological Assay;Businesses;Carbohydrates;Cell Line;Cell surface;Cell Surface Receptors;Cells;Cessation of life;Charge;China;Computing Methodologies;copolymer;cost;COVID-19;COVID-19 assay;COVID-19 pandemic;cross reactivity;current pandemic;cycloaddition;cytotoxicity;Death Rate;Dendrimers;design;design,build,test;Development;Disease;Electrons;Electrostatics;Energy Transfer;Enzyme-Linked Immunosorbent Assay;Evaluation;FDA Emergency Use Authorization;fighting;Future;future pandemic;Goals;Grant;Heparan Sulfate Proteoglycan;Herd Immunity;HIV;HIV Envelope Protein gp120;HIV-1;illness length;improved;In Vitro;Infection;inhibitor;innovation;iterative design;Length;Life;Link;Location;Luciferases;Measures;Membrane Glycoproteins;Methods;molecular dynamics;monomer;Morbidity - disease rate;mortality;novel;Outcome;Oximes;pandemic disease;pathogen;Patients;Persons;Polymers;Porphyrins;Positron-Emission Tomography;prevent;Process;Proteins;receptor;Recording of previous events;remdesivir;SARS-CoV-2 spike protein;school closure;screening;sugar;Sulfate;Sulfur;Time;Vaccines;Viral;Viral Physiology;Viral Proteins;Virus;Virus Diseases;Vulnerable Populations;Work;Zoonoses

PROJECT_TITLE: Glycopolymer Inhibitors of Heparan Sulfate Proteoglycan Binding Pathogens