NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Immunization;Immunotherapy;Skin Cancer;Vaccine Related

PHR: NARRATIVE In a recently completed pilot clinical trial administering a dendritic cell-based vaccine targeting tumor vascular antigens (αDC1/TBVA) + dasatinib, we observed a high rate of responses (4 of 7 patients; 57% ORR) in melanoma patients who had previously exhibited primary resistance to anti-PD1 checkpoint blockade and objective clinical benefit overall in 6 of 13 patients (46% DCR) on that trial. Treatment benefit was associated with changes in the balance of pro-inflammatory vs. regulatory chemokines and with immune infiltration (including the formation of tertiary lymphoid structures and evidence for T cell repertoire diversification) within patients’ tumors. These striking clinical data and our mouse studies showing much stronger therapeutic synergy between αDC1/TBVA and the chemokine-modulating regimen (CKM) developed within Project 1, compared to dasatinib, prompted us to perform a larger phase II study to evaluate the ability of αDC1/TBVA+CKM to induce objective clinical responses in patients with primary PD1-refractory, advanced-stage melanoma, identify the underlying mechanisms, and develop tools for prospective studies of survival benefit.

PI_NAMEs: STORKUS, WALTER J. (contact)

PROJECT_TERMS: Aftercare;Animal Model;antagonist;anti-PD-1;anti-PD-L1;Antigens;Autologous;Biopsy;Blood;Blood Vessels;CCL19 gene;CCL21 gene;CCL22 gene;CD8-Positive T-Lymphocytes;CD8B1 gene;celecoxib;Cells;chemokine;Clinical;Clinical Data;clinical efficacy;Clinical Trials;Clinical Trials Design;clinically relevant;Combination immunotherapy;Combined Vaccines;Common Neoplasm;comparative;Cross-Priming;CXCL9 gene;Dasatinib;Data;Dendritic Cells;design;Development;Epitope spreading;Equilibrium;Evaluable Disease;Exhibits;experimental study;Harvest;HLA-A2 Antigen;Immune;immune cell infiltrate;immune checkpoint blockade;Immune checkpoint inhibitor;Immunologics;Immunotherapy;improved;in situ vaccine;Inflammatory;Interferon alpha;Interferons;Intervention;Ligands;Link;Lymphoid;Malignant Neoplasms;MC38;Melanoma;Melanoma patient;Modeling;Molecular;Molecular Mechanisms of Action;Monitor;Mus;Myeloid-derived suppressor cells;Natural Killer Cells;Neoplasms in Vascular Tissue;novel;Pathway interactions;Patients;PD-1 blockade;PD-1/PD-L1;peptide based vaccine;peptide vaccination;Peptide Vaccines;Peptides;peripheral blood;phase 2 study;Phase I/II Trial;Play;Production;programmed cell death protein 1;Progression-Free Survivals;prospective;Prospective Studies;Protocols documentation;RANTES;recruit;Refractory;Regimen;Regulatory T-Lymphocyte;Resistance;response;Role;Stromal Cell-Derived Factor 1;Structure;Suppressor-Effector T-Lymphocytes;synergism;System;T cell infiltration;T cell response;T cell therapy;T-Lymphocyte;tertiary lymphoid organ;Testing;Th1 Cells;Therapeutic;Therapeutic Intervention;Tissues;tool;Treatment Efficacy;treatment site;tumor;tumor microenvironment;Up-Regulation;Vaccination;Vaccines

PROJECT_TITLE: Project 3: Chemokine modulation in TME for enhanced TLS formation and cross-priming/ recruitment of therapeutic CD8+ TILs


ADMINISTERING_IC: CA

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Immunotherapy

ORG_CITY: BUFFALO

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: ROSWELL PARK CANCER INSTITUTE CORP

ORG_STATE: NY

PHR: PROJECT NARRATIVE The Administrative Core (Core A) will provide overall oversight of the clinical and laboratory research proposed within this clinically-oriented P01 Program Project. Core A is directed by Dr. Pawel Kalinski, the Principal Investigator of this Program. Dr. Kalinski has direct work experience at the two participating institutions, Roswell Park Cancer Comprehensive Cancer Center (Roswell Park) and the University of Pittsburgh. Core A will provide the overall supervision of the research within this Program Project, promote effective interactions with additional academic and biotech and pharma partners, data dissemination, the interactions with NCI and the Internal and External Advisors, along with interactions with concurrent program projects at the participating institutions.

PI_NAMEs: KALINSKI, PAWEL  (contact)

PROJECT_TERMS: Academia;Biotechnology;chemokine;Clinical;Clinical Management;Clinical Research;Communication;Communities;Comprehensive Cancer Center;data dissemination;data sharing;Development;Ensure;experience;Foundations;General Population;Grant;Hospitals;Immunotherapy;Institution;Laboratories;Laboratory Research;Malignant Neoplasms;meetings;member;Occupational activity of managing finances;Participant;Preparation;Principal Investigator;Program Research Project Grants;Program Reviews;programs;Progress Reports;Reporting;Research;Research Project Grants;Resource Sharing;Supervision;System;tumor;United States National Institutes of Health;Universities;Videoconferencing;Woman;Work

PROJECT_TITLE: Core A: Administrative Core


PHR: The role of Core B (Biostatistics and Informatics Core) is to ensure that the appropriate analytic techniques and careful data management are implemented across all the P01 projects. We will ensure that appropriate support for the design of experiments and clinical protocols, data management and modeling is readily available to all P01 project leaders, co-investigators and support staff. The Core will contribute to the P01 research directed towards improving cancer outcomes through modulation of chemokine production within tumor tissues.

PI_NAMEs: YU, HAN  (contact)

PROJECT_TERMS: Address;Attention;Award;Basic Science;bioimaging;Bioinformatics;Biometry;chemokine;Clinical;Clinical Protocols;Clinical Sciences;Clinical Trials;Clinical Trials Design;Collaborations;Communities;Computer software;Data;Data Analyses;Data Collection;data management;data modeling;data quality;data sharing;data sharing networks;Dedications;design;Electronic Mail;Ensure;Experimental Designs;Faculty;Formulation;Fostering;Funding;Goals;high standard;Immunooncology;Immunotherapy;improved;Individual;Informatics;Infrastructure;innovation;Lead;Malignant Neoplasms;Manuscripts;meetings;member;Methodology;Modeling;novel;Outcome;pathology imaging;Privacy;Procedures;Process;Production;Productivity;programs;Progress Reports;Protocol Compliance;Reporting;Research;Research Personnel;Resources;Role;Services;symposium;System;Techniques;Telephone;translational oncology;Translational Research;tumor;Tumor Tissue;Update;web site;Work

PROJECT_TITLE: Core B: Biostatistics and Informatics


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Immunization;Immunotherapy;Patient Safety;Vaccine Related

PHR: Core C (Clinical) will provide integrated oversight, and coordination for all clinical components of this P01, supporting the implementation and completion of the clinical trials performed within this P01: production and distribution of cGMP vaccines, immune monitoring of patients and collection of clinical data. In years 1-3, Core C will support timely completion of the three clinical trials proposed in Specific Aims 1 of the three Projects, coordinated analysis of their efficacy (immunologic and clinical) and potential side effects (with Cores B and D). Based on these data and results of laboratory studies performed in SA2s of all projects, in years 3-5 Core C will help finalize the designs of the clinical trials constituting Specific Aims 3 of Project 1 and Project 2 (combinations with PD-1 blockade), their approval, implementation and timely completion, as well as coordinated analysis of their results.

PI_NAMEs: PUZANOV, IGOR  (contact)

PROJECT_TERMS: Antigens;Area;Biological Markers;Blood;Blood specimen;cancer immunotherapy;Cells;cGMP production;chemokine;Clinical;Clinical Data;clinical efficacy;Clinical Management;clinical predictors;Clinical Protocols;clinical trial analysis;Clinical Trials;Clinical Trials Design;Collaborations;Collection;cost;Cyclic GMP;Data;Dendritic Cell Therapy;Dendritic Cell Vaccine;Dendritic Cells;Development;early phase clinical trial;experience;follow-up;Funding;Guidelines;Harvest;Hospitals;Human;Human Resources;Immune response;Immunologic Monitoring;Immunologics;Immunotherapy;immunotherapy trials;Individual;Institution;Institutional Review Boards;Investigational Therapies;Laboratories;Laboratory Study;Lead;Leukapheresis;Logistics;Malignant neoplasm of ovary;Malignant Neoplasms;manufacture;Monitoring Clinical Trials;participant enrollment;Patient Monitoring;Patients;PD-1 blockade;Pharmacologic Substance;preservation;Process;process improvement;Production;programs;prospective;Protocols documentation;recruit;Reporting;Resources;response;Review Committee;Role;side effect;Site;System;Testing;Tissue Banks;Triage;tumor;United States National Institutes of Health;Vaccine Clinical Trial;Vaccines;Woman

PROJECT_TITLE: Core C: Clinical Management and Resources


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Immunization;Immunotherapy;Orphan Drug;Ovarian Cancer;Rare Diseases;Vaccine Related;Women's Health Research

PHR: NARRATIVE Core D (Pathology and Bio-Imaging Core), directed by Dr. Morrison, MD, will support this clinically oriented Program by providing tissue banking and annotation services, as well as comprehensive state-of-the-art evaluation of the immune status of tumor microenvironments (TME), using cutting-edge platforms for comprehensive immune profiling, cell and tissue analysis, ex vivo and in vivo imaging and image analysis.

PI_NAMEs: BSHARA, WIAM  (contact)

PROJECT_TERMS: Aftercare;Animals;Archives;bioimaging;Biological Assay;Bioluminescence;Biopsy;Blood Vessels;CD3 Antigens;CD8B1 gene;Cell Communication;Cell Culture Techniques;Cells;chemokine;chemokine receptor;CLIA certified;Clinical;Clinical Trials;Clonal Expansion;Clonality;Collection;Color;Colorectal Neoplasms;Comprehensive Cancer Center;Computer Assisted;Computers;density;design;Development;DNA sequencing;Doctor of Philosophy;Drug or chemical Tissue Distribution;Effector Cell;Ensure;Epitope spreading;Evaluation;Exhibits;experimental study;FDA approved;Flow Cytometry;Fluorescence Microscopy;Fluorescent in Situ Hybridization;Freezing;Genes;Genomics;Growth;Human;Image;Image Analysis;Image Cytometry;Immune;immune checkpoint;Immune Response Genes;Immunofluorescence Immunologic;Immunohistochemistry;immunological intervention;immunological status;Immunologics;Immunotherapy;in vivo;in vivo imaging;Infrastructure;innovation;Ions;Kinetics;Laboratories;Lasers;lymphoid structures;Magnetic Resonance Imaging;Measures;medical schools;Melanoma Tumor;Microsatellite Instability;morphometry;mouse model;multimodality;Mus;Mutation;Myeloid-derived suppressor cells;New York;novel;Optics;Outcome;Ovarian;ovarian neoplasm;Pathology;pathology imaging;Patients;Pattern;PD-1 blockade;PD-1/PD-L1;Population;preclinical study;Process;Program Evaluation;programmed cell death ligand 1;programmed cell death protein 1;programs;protein expression;Protocols documentation;PTGS2 gene;Recording of previous events;Regimen;Regulatory T-Lymphocyte;Reporting;Reproducibility;Research Personnel;Resource Sharing;Role;sample collection;Sampling;Scanning;Services;Site;sound;Source;Specimen;System;T cell infiltration;T cell response;T-cell diversity;T-Lymphocyte;Technology;Testing;Tissue Banks;tissue culture;Tissue Procurements;Tissues;Transcript;transcriptome sequencing;transcriptomics;treatment effect;tumor;tumor growth;tumor microenvironment;Tumor Tissue;Universities;Vaccination;Vaccines;Work

PROJECT_TITLE: Core D: Pathology and BioImaging


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Hematology;Nanotechnology;Obesity;Wound Healing and Care

ORG_CITY: SYRACUSE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UPSTATE MEDICAL UNIVERSITY

PHR: Targeting neutrophils to harness myeloid responses for wound healing Project narrative: Chronic wounds represent a significant health problem in the United States with millions of afflicted patients and the associated treatment billions of dollars per year. In the proposed research, we will investigate how chronic wounds and associated obesity dysregulate white blood cells that contribute to the poor healing responses in these conditions. Findings from our experiments will provide insight into whether therapies and tests targeting a type of white blood cells can improve the healing of wounds and can aid in the selection of treatment options that are currently available for treating chronic wounds. The long-term goal of this project is to reduce the socioeconomic burden of chronic wounds and associated obesity and improve the quality of life of these patients.

PI_NAMEs: URAO, NORIFUMI  (contact)

PROGRAM_OFFICER_NAME: CHAO, CHIEN-CHUNG

PROJECT_TERMS: aged;assay development;Biological Markers;Biomedical Engineering;Bone Marrow;Cell Death;Cessation of life;Chronic;chronic wound;comparative;Data;Diabetes Mellitus;Drug Targeting;Economic Burden;experimental study;extracellular vesicles;genetic manipulation;Genetic Models;Glutaminase;Glutamine;Goals;healing;Health;Hematopoietic stem cells;Homing;Human;Impaired healing;Impaired wound healing;improved;in vivo;Inflammation;Inflammatory;inhibitor;insight;Knowledge;Leukocytes;Link;loss of function;Macrophage;Metabolic;Metabolism;Monitor;mouse model;Mus;Myelogenous;Myeloid Cells;Myeloid Progenitor Cells;Myelopoiesis;nanocarrier;nanodrug;neutrophil;novel;novel drug class;novel marker;Obese Mice;Obesity;Organ;Patients;pre-clinical;Pre-Clinical Model;Process;Quality of life;regenerative;Research;response;Risk;Selection for Treatments;skin wound;Skin wound healing;socioeconomics;Specimen;Testing;Tissues;translational potential;translational study;Translations;Treatment Cost;United States;Up-Regulation;vesicular release;wound;wound healing;Wound models;wound response

PROJECT_TITLE: Targeting neutrophil clearance to harness myeloid responses for wound healing.

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


ADMINISTERING_IC: HL

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: HILLSBOROUGH

ORG_NAME: HELIXOMER, INC.

ORG_STATE: NC

PHR: PROJECT NARRATIVE Anticoagulant treatment can prevent thrombosis and major ischemic events, such as pulmonary embolism, heart attack, and stroke, but the anticoagulant/reversal agent pair most commonly used during surgical procedures, unfractionated heparin (UFH) and protamine, is associated with serious acute side effects, dosing errors, hemorrhage, and thrombosis. To meet the need for safer alternatives to UFH and protamine, Helixomer, Inc. is developing an innovative RNA-origami-based anticoagulant and a corresponding DNA-based reversal agent with predictable dose response profiles. In this Direct-to-Phase II project, Helixomer will validate essential bioanalytical methods for quantifying drug concentrations in plasma, determine dosing strategies in a large- animal model, determine the maximum tolerated dose, and assess the safety and toxicity of these novel drugs in preparation for a future first-in-human clinical trial.

PI_NAMEs: KRISSANAPRASIT, ABHICHART  (contact)

PROGRAM_OFFICER_NAME: GOLDBERG, ILANA GRACE

PROJECT_TERMS: Acute;Address;Affect;Affinity;American;analytical method;Anaphylaxis;Animal Model;Anticoagulants;Anticoagulation;Antidotes;Appearance;aptamer;assay development;Base Pairing;Binding;Biodistribution;Biological;Biological Assay;Blood;Blood Coagulation Factor;Canis familiaris;Cardiac Surgery procedures;Cardiovascular system;Cessation of life;Clinical;clinical practice;Clinical Trials;Coagulation Process;Data;Deep Vein Thrombosis;Deposition;Detection;detection assay;Development;Dialysis procedure;DNA;Dose;Endotoxins;Enzyme-Linked Immunosorbent Assay;Enzymes;Euthanasia;Event;experience;Extracorporeal Membrane Oxygenation;Family suidae;Fibrin;first-in-human;Future;Genetic Transcription;heart valve replacement;Hemorrhage;Hemostatic Agents;Heparin;heparin-induced thrombocytopenia;Hospitalization;Hour;Human;Hypersensitivity;Immune response;immunotoxicity;In Vitro;in vivo;Industry Standard;innovation;Intravenous;Ischemia;Kinetics;large scale production;Lead;Life;Liquid substance;manufacture;manufacturing scale-up;Maximum Tolerated Dose;Medical;Medication Errors;meetings;Methods;Mus;Myocardial Infarction;nano;novel;novel therapeutics;Operative Surgical Procedures;Overdose;patient variability;Patients;Pharmaceutical Preparations;Phase;Plasma;Polynucleotides;porcine model;Postoperative Period;preclinical development;preclinical study;Preparation;prevent;Procedures;Production;Protamines;Pulmonary Embolism;Rattus;Reaction;Resistance;response;Risk;RNA;Safety;safety assessment;Saline;Shapes;side effect;Single-Stranded DNA;Small Business Innovation Research Grant;Stroke;Therapeutic;Thrombin;Thrombosis;Time;Tissues;Toxic effect;Toxicology;Work

PROJECT_TITLE: Development of an RNA-based anticoagulant and antidote for precise on/off coagulation control during cardiovascular procedures

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-VH-V(11)B]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: CLEVELAND

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE The Computational Genomic Epidemiology of Cancer (CoGEC) training program provides transdisciplinary, postdoctoral training at the intersection of cancer research, epidemiology, biostatistics, genetics, and computer science. CoGEC catalyzes the integration of multidisciplinary cancer genetics and genomics research within the Case Comprehensive Cancer Center. Thus, developing highly dynamic and interactive new investigators with the expertise to lead integrated research teams conducting the most promising and forward-looking cancer research.

PI_NAMEs: LAFRAMBOISE, THOMAS LOUIS;XU, RONG  (contact)

PROGRAM_OFFICER_NAME: LIM, SUSAN E

PROJECT_TERMS: cancer epidemiology;genomic epidemiology;Training Programs

PROJECT_TITLE: Computational Genomic Epidemiology of Cancer (CoGEC) Training Program

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


NIH_SPENDING_CATS: Lung

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: Project Narrative Lung disease is one of the leading causes of death and disability worldwide, but common lung diseases remain poorly understood and current therapies have serious limitations. There is thus a pressing need for high quality basic, translational and clinical research in lung disease. This application proposes support for the UCSF pulmonary training program that for the past 44 years has trained many of the world’s leading scientists in lung biology and medicine.

PI_NAMEs: ERLE, DAVID J;HUANG, LAURENCE ;SHEPPARD, DEAN ;WOODRUFF, PRESCOTT G (contact)

PROGRAM_OFFICER_NAME: REYES, MADELYN

PROJECT_TITLE: Multidisciplinary Training Program in Lung Disease

STUDY_SECTION: NITM

STUDY_SECTION_NAME: NHLBI Institutional Training Mechanism Study Section[NITM(OA)]


ADMINISTERING_IC: AA

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Genetics;Human Genome;Neurosciences;Substance Misuse

ORG_CITY: RICHMOND

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: /// PROJECT NARRATIVE \\\ Alcohol use disorder (AUD) is a common medical condition characterized by an impaired ability to stop or control alcohol use despite adverse social, occupational, or health consequences. To better understand gene expression changes in the brain associated with AUD, we propose single nuclei sequencing of the brain transcriptome in multiple brain regions to identify cell-type specific gene expression differences. Successful completion of this project will yield (i) unprecedented insights into AUD disease mechanisms, (ii) possible blood biomarkers of genes differentially expressed in brain, and (iii) lay the foundation for functional follow-up studies and, eventually, novel highly specific clinical interventions for improving AUD treatment.

PI_NAMEs: ABERG, KAROLINA ANNA;CLARK, SHAUNNA L;VAN DEN OORD, EDWIN  (contact)

PROGRAM_OFFICER_NAME: LORANG-LEINS, DOMINIQUE

PROJECT_TERMS: Affect;Alcohol consumption;alcohol use disorder;Autopsy;bioinformatics tool;Biological Markers;Blood;Brain;brain cell;Brain region;case control;Cell Nucleus;cell type;Cells;Chromatin;Clinical;Collection;comorbidity;Data;Data Set;design;differential expression;Disease;Ensure;Etiology;Evolution;experimental study;Failure;follow-up;Follow-Up Studies;Foundations;Gene Expression;Genes;Genetic;genetic element;Genetic Markers;genome wide association study;Goals;Grain;Health;Hippocampus;Impairment;improved;Individual;insight;Intervention;Medical;Methylation;novel;Nucleus Accumbens;Occupational;Pilot Projects;power analysis;Prefrontal Cortex;Prevalence;Procedures;Process;Race;Reaction;Regulatory Element;Research Design;Sampling;Series;sex;Signal Transduction;single nucleus RNA-sequencing;social;Technology;Testing;Tissues;transcriptome;transcriptomics;Validation

PROJECT_TITLE: Single cell transcriptomic study of alcohol use

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


ADMINISTERING_IC: AR

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Aging;Arthritis;Bioengineering;Nanotechnology;Osteoarthritis;Physical Injury - Accidents and Adverse Effects;Prevention

ORG_CITY: Newark

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF DELAWARE

ORG_STATE: DE

PHR: PROJECT NARRATIVE Post-traumatic osteoarthritis is a crippling disease that can rapidly affect over half of patients suffering acute joint injuries, such as ACL ruptures and meniscal tears, as well as patients with overuse injuries. Presently, there are no clinical treatments that can prevent the initiation and progression of PTOA after joint injury, and the translation of therapeutic candidates with PTOA-disease modifying potential has been hindered by poor targeting to and rapid clearance of therapeutics from the joint. In this program, we will demonstrate the feasibility of novel collagen-targeting, thermoresponsive approaches for localizing candidate drugs to the injured joint and extending their ability to prevent/mitigate PTOA, thereby improving treatment efficacy and reducing costs.

PI_NAMEs: KIICK, KRISTI L (contact);PRICE, CHRISTOPHER

PROGRAM_OFFICER_NAME: PINTUCCI, GIUSEPPE

PROJECT_TERMS: Acceleration;Acute;Affect;anakinra;analog;anterior cruciate ligament rupture;articular cartilage;Binding;Biodistribution;Biological;biomaterial compatibility;Body Temperature;Bone structure;Cartilage;cell injury;Cells;Chondrocytes;Clinical;Clinical Treatment;Collagen;Consultations;controlled release;cost;cost effective;Cumulative Trauma Disorders;Degenerative polyarthritis;design;Development;Dexamethasone;Disease;Disease Management;Disease Progression;Dose;Doxycycline;drug candidate;Drug Carriers;drug clearance;Drug Controls;Drug Delivery Systems;drug efficacy;Drug Kinetics;Drug Targeting;Effectiveness;Elastin;Etiology;Exhibits;experimental study;Extracellular Matrix;Fibroblasts;Foundations;Histologic;immunogenicity;improved;In Situ;In Vitro;in vivo;Inflammation;injured;Injury;Intervention;Intra-Articular Injections;Investigation;joint inflammation;joint injury;joint loading;Joints;Knee Injuries;Knee joint;Label;Letters;light scattering;Lipids;Liposomes;Macrophage;Matrix Metalloproteinase Inhibitor;Mediating;meniscal tear;Methods;Microscopy;Minerals;Modeling;Modification;Monitor;monocyte;Mus;nanoparticle;nanovesicle;natural hypothermia;Nature;novel;Outcome;palliative;Pathology;Patients;Peptides;Pharmaceutical Preparations;Pharmacologic Substance;Physiology;Polymers;pre-clinical;preclinical study;preservation;prevent;Prevention;Price;programs;prophylactic;residence;Safety;Spectrum Analysis;Strontium;Synovial Fluid;targeted delivery;targeted treatment;Temperature;Testing;Therapeutic;therapeutic candidate;Time;Tissues;translational potential;translational therapeutics;Traumatic Arthropathy;Treatment Efficacy;Vesicle;Work

PROJECT_TITLE: Collagen-mediated approaches to improve the local delivery and hypothermic release of osteoarthritis therapeutics

STUDY_SECTION: MTE

STUDY_SECTION_NAME: Musculoskeletal Tissue Engineering Study Section[MTE]


ED_INST_TYPE: UNIVERSITY-WIDE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Asthma;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Lung;Prevention;Social Determinants of Health

ORG_CITY: BOSTON

ORG_NAME: HARVARD MEDICAL SCHOOL

ORG_STATE: MA

PHR: Project Narrative Asthma is a major global health burden, yet research on the potential utility of large-scale genome-wide and phenome-wide approaches for asthma risk prediction remains limited. This project proposes to apply statistical methods to develop integrated models of asthma risk with polygenic and environmental risk predictors in diverse populations. These analyses will advance our understanding of genetic and environmental contributions to asthma risk and provide novel approaches for studying asthma across populations.

PI_NAMEs: TSUO, KRISTIN MAY (contact)

PROGRAM_OFFICER_NAME: SHENOY, SIDDHARTH KAUP

PROJECT_TERMS: Adult;Affect;Airway Disease;Architecture;Asthma;asthma model;asthmatic;biobank;Childhood;Clinical;clinical decision-making;cohort;Complex;Development;Disease;Disease Management;Disparity;Doctor of Philosophy;Environmental Exposure;Environmental Risk Factor;epidemiology study;European ancestry;Evaluation;experience;Factor Analysis;Failure;Family;Fellowship;Foundations;Future;General Hospitals;Genetic;genetic analysis;genetic architecture;genetic information;Genetic Predisposition to Disease;Genetic Risk;genetic risk factor;genetic variant;genome wide association study;genome-wide;Genomics;global health;Goals;health disparity;Heritability;improved;indexing;Individual;Inflammatory;insight;Intervention;Joints;Massachusetts;Measures;Mentorship;Methods;Modeling;novel;novel strategies;Performance;Persons;phenome;Phenotype;polygenic risk score;Polygenic Traits;Population;population based;Population Heterogeneity;predictive modeling;predictive tools;prevent;Prevention;Principal Investigator;Prognosis;prognostication;programs;Reporting;Research;Research Personnel;Resources;Risk;Risk Factors;Risk Marker;risk prediction;risk prediction model;Sample Size;Statistical Methods;Testing;Time;tool;Training;trait;Underrepresented Populations;Variant;Work

PROJECT_TITLE: Integrating polygenic and environmental risk factors for asthma in diverse populations

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F18-D(20)L]


NIH_SPENDING_CATS: Brain Disorders;Cancer;Climate-Related Exposures and Conditions;Genetics;Skin Cancer

ORG_CITY: DURHAM

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: DUKE UNIVERSITY

PHR: Acquisition of invasive phenotypes is critical for progression from primary to metastatic melanoma which is most detrimental for patient survival in case of melanoma brain metastases (MBMs). The goal of our proposal is to elucidate mechanisms controlling melanoma cell invasion via recruitment of GTP biosynthesis enzymes to protrusions of invading cells and transcriptional upregulation of GTP biosynthesis, and to test inhibition of GTP biosynthesis as a treatment strategy for MBM in preclinical models.

PI_NAMEs: NIKIFOROV, MIKHAIL  (contact)

PROGRAM_OFFICER_NAME: AULT, GRACE S

PROJECT_TERMS: Anabolism;anti-hepatitis C;anti-tumor immune response;Automobile Driving;Biogenesis;Biology;Blood - brain barrier anatomy;Cell membrane;Cells;Cephalic;Chemicals;Clinic;clinically relevant;Co-Immunoprecipitations;Communication;curative treatments;Data;Data Reporting;Dependence;disease model;Dissociation;Dose;effective therapy;efficacy testing;enzyme biosynthesis;Enzymes;Event;Gene Expression;gene expression database;Gene Expression Profiling;Genetic Transcription;Goals;Guanosine Triphosphate;Immune response;Immunosuppressive Agents;Immunotherapy;IMPDH2 gene;inhibitor;Inosine Monophosphate;Invaded;Link;Lipids;MAP Kinase Gene;Melanoma;Melanoma Cell;Melanoma patient;Melanoma Tumor;Membrane;Membrane Microdomains;Messenger RNA;Metabolism;Metastatic malignant neoplasm to brain;Metastatic Melanoma;Methods;Modification;mouse model;Mus;Mutagenesis;Mutation;mycophenolate mofetil;Nature;Neoplasm Metastasis;novel;novel strategies;Oxidoreductase;Paper;Pathway interactions;Patients;Penetration;Pharmaceutical Preparations;Phenotype;Physiological;PI3K/AKT;Plasma Cells;Play;Pre-Clinical Model;Prognosis;programmed cell death ligand 1;programs;Proliferating;Protein Analysis;protein transport;Proteinase 3;Proteins;Radiosurgery;recruit;Regulation;Reporting;rho GTP-Binding Proteins;Ribavirin;Role;Signal Transduction;Site;Skin Cancer;STAT3 gene;Sun Exposure;Testing;Transactivation;transcription factor;Transcriptional Activation;treatment strategy;Tumor Escape;Tumorigenicity;Up-Regulation

PROJECT_TITLE: The role of regulation and subcellular localization of GTP biosynthesis in melanoma invasion and metastasis

STUDY_SECTION: TEHM

STUDY_SECTION_NAME: Tumor Evolution, Heterogeneity and Metastasis Study Section[TEHM]


NIH_SPENDING_CATS: Cancer;Prevention

ORG_DEPT: FAMILY MEDICINE

PHR: PROJECT NARRATIVE The T32 Cancer Prevention and Control and Cancer Health Equity (CPC-CHE) program is one of the longest- standing NCI-funded training programs at the Massey Cancer Center at Virginia Commonwealth University. It has a proven history of training successful investigators in cancer prevention and control and cancer equity science. The program’s focus on cancer health equity science fills a gap in the field by training a cadre of new investigators to further science in this area.

PI_NAMEs: FUEMMELER, BERNARD F (contact);PALESH, OXANA G

PROGRAM_OFFICER_NAME: BOULANGER-ESPEUT, CORINNE A

PROJECT_TERMS: Cancer Control;Cancer health equity;cancer prevention;Training Programs

PROJECT_TITLE: Training Program in Cancer Prevention and Control and Cancer Health Equity (CPC-CHE)


NIH_SPENDING_CATS: Bioengineering;Biotechnology

ORG_CITY: HADLEY

ORG_NAME: UNIVERSITY OF MASSACHUSETTS AMHERST

PHR: PROJECT NARRATIVE X-ray crystallography is responsible for the majority of structural knowledge of biology at the molecular level. However, most of this knowledge has been established by observing static endpoints related to macromolecular function. We are developing novel fixed-target approaches to enable the next generation of serial time-resolved X-ray crystallography experiments to directly probe structural dynamics and advance the field of structural biology as a whole.

PI_NAMEs: PERRY, SARAH LOUISE (contact)

PROGRAM_OFFICER_NAME: TAYLOR, VERONICA

PROJECT_TERMS: 3-hydroxy-3-methylglutaryl-coenzyme A;Address;Affect;Attention;base;beamline;Biological;Biology;biomacromolecule;Chemicals;Coenzyme M;Collaborations;Collection;Communities;Consumption;cost;Coupled;Crystallography;Data;Data Collection;Dehydration;Democracy;design;Development;Devices;electric field;Electron Transport;Electronics;Environment;experimental study;fabrication;Future;Generations;Goals;graphene;Heat shock proteins;Human;hydrodynamic flow;Image;improved;In Situ;Influenza Hemagglutinin;Knowledge;Laboratories;Lasers;Light;Location;Massachusetts;Measurement;Metals;Methods;Microfluidic Microchips;Microfluidics;Mitochondria;Molecular;Motion;new technology;next generation;Noise;novel;Optics;Oxidoreductase;Oxygen;Performance;Phosphoric Monoester Hydrolases;Photons;Polymers;prevent;Protein Dynamics;protein structure;Proteins;Qualifying;Reaction;Reaction Time;Recording of previous events;Reporting;Research;Research Design;Research Personnel;Robotics;Roentgen Rays;Sampling;Science;sensor;Signal Transduction;Source;Spectrum Analysis;Stream;structural biology;Structure;Structure-Activity Relationship;Synchrotrons;System;Technology;temperature jump;Testing;Time;Translations;United States National Institutes of Health;Universities;Validation;voltage;Work;X ray diffraction analysis;X-Ray Crystallography;x-ray free-electron laser

PROJECT_TITLE: Fixed-Target Platforms for Time-Resolved Crystallography

STUDY_SECTION: ISD

STUDY_SECTION_NAME: Instrumentation and Systems Development Study Section[ISD]


NIH_SPENDING_CATS: Cancer;Clinical Research;Lung;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: COLUMBUS

ORG_NAME: RESEARCH INST NATIONWIDE CHILDREN'S HOSP

PHR: Osteosarcoma is a bone cancer that kills young people when it spreads to the lungs, which it does with unusual frequency. While seeking to understand why this tumor has such preference for lung tissue, we discovered that the structural cells of the lung (epithelial cells) induce changes in osteosarcoma cells that creates cells with different behaviors. By understanding the ways that these distinct subpopulations of tumor cells cooperate to establish metastases and resist the effects of chemotherapy, we hope to design therapies that make this previously-untreatable disease treatable.

PI_NAMEs: ROBERTS, RYAN D. (contact)

PROGRAM_OFFICER_NAME: SNYDERWINE, ELIZABETH G

PROJECT_TERMS: Adopted;Aftercare;Antibodies;Appearance;Automobile Driving;Bar Codes;Behavior;Biology;cancer cell;Cell Communication;Cell division;cell growth;Cell Survival;cell type;Cells;cellular engineering;Characteristics;chemotherapy;Child;Childhood;Clinical;clinical care;conventional therapy;cytokine;Data;Data Set;Development;Developmental Process;Disease;Disease Resistance;Environment;Epithelial Cells;Exposure to;Extracellular Matrix;Frequencies;Genetic Transcription;Growth;healing;Human;IL-6 inhibitor;IL6 gene;IL8 gene;improved outcome;In Vitro;in vivo Model;Individual;Inflammatory;inhibitor;Integrins;Interleukin-1;Intervention;Laboratories;Lesion;Lung;Lung Neoplasms;Maintenance;Malignant Bone Neoplasm;Metastatic Neoplasm to the Lung;mouse model;Mus;Neoplasm Metastasis;neoplastic cell;Nodule;novel;Organoids;Osteosarcoma;paracrine;Patient Care;Persons;Pharmaceutical Preparations;pharmacologic;Phenotype;Play;Population;Positioning Attribute;preference;prevent;Primary Neoplasm;Production;Proliferating;Property;Reaction;recruit;Regimen;Relapse;Reporter;Research;Resistance;Resolution;response;Role;senolytics;Signal Transduction;single cell ATAC-seq;single-cell RNA sequencing;standard of care;Stress;Structure of parenchyma of lung;System;targeted treatment;Teenagers;Testing;therapeutic candidate;therapeutic development;Therapeutic Intervention;therapy design;Time;Tissues;Toxic effect;Translating;Treatment Protocols;tumor;Work;wound;wound healing;wound response

PROJECT_TITLE: Targeting cooperative mechanisms of metastatic colonization in osteosarcoma

STUDY_SECTION: TPM

STUDY_SECTION_NAME: Tumor Progression and Metastasis Study Section[TPM]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Precision Medicine

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: PROJECT NARRATIVE Cancer researchers and clinicians are now using the power of human genome sequencing to analyze tumor samples from many thousands of cancer patients in their quest to cure cancer. The cBioPortal for Cancer Genomics is a widely used, user-friendly web resource that enables researchers to visualize, analyze, and interpret these big and complex data sets to make new discoveries. In this project, a collaborative team from major cancer centers will maintain and further develop the cBioPortal software, facilitating a better understanding of the genomic basis of cancer and guiding personalized therapy.

PI_NAMEs: CERAMI, ETHAN ;GAO, JIANJIONG ;SANDER, CHRIS ;SCHULTZ, NIKOLAUS  (contact)

PROGRAM_OFFICER_NAME: LI, JERRY

PROJECT_TERMS: Acceleration;Address;American Association of Cancer Research;anti-cancer research;Architecture;Area;base;Big Data;Biological Assay;Biological Markers;Biotechnology;cancer care;Cancer Center;cancer genomics;cancer initiation;Cancer Patient;cBioPortal;Clinical;Cloud Computing;Code;Collaborations;Communities;Community Outreach;complex data;Computer software;Consultations;Dana-Farber Cancer Institute;Data;Data Analyses;data mining;data pipeline;Data Set;data sharing;data visualization;Development;Ecosystem;Education and Outreach;Ensure;Funding;Future;Genes;GENIE;genomic data;genomic profiles;Genomics;Growth;hackathon;human genome sequencing;Imaging Techniques;improved;insight;Institution;Internet;interoperability;large datasets;Licensing;Malignant Neoplasms;medical schools;Memorial Sloan-Kettering Cancer Center;Molecular;molecular imaging;Molecular Profiling;novel;online resource;open source;outreach;Patient Care;Pediatric Hospitals;Performance;personalized medicine;Pharmaceutical Preparations;Pharmacologic Substance;Philadelphia;precision medicine;precision oncology;programs;Publishing;Research;research and development;Research Personnel;Resources;Sampling;Scientist;Series;Services;Site;social media;software development;Technology;technology platform;tool;Traction;Training;treatment effect;tumor;usability;user-friendly;Variant;Visualization;web portal;webinar

PROJECT_TITLE: The cBioPortal for Cancer Genomics


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: MADISON

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE Dramatic increases in mothers' labor force participation coupled with increases in precarious and nonstandard jobs over the past 50 years call for new research to examine how these changes have transformed families' daily lives, and in turn, impacted children's health and development. The proposed research aims to: (1) document and explain trends in mothers' work hours and schedules over the past 30 years; (2) assess how the associations between mothers' work schedules, mothers' time with children, and child care arrangements have changed over time and as a result of increased public spending on child care and early education programs; and (3) determine how mothers' work schedules are associated with children's health and developmental outcomes in a contemporary, nationally-representative sample of U.S. children. The project will generate novel findings on how mothers' employment matters for child health and development that are necessary for making informed policy decisions about how to best support families in order to improve child health and well-being.

PI_NAMEs: PILARZ, ALEJANDRA ROS (contact)

PROGRAM_OFFICER_NAME: JEKIELEK, SUSAN

PROJECT_TERMS: 5 year old;Adverse effects;Age;American;Area;Behavioral;career;Caring;Characteristics;Child;Child Care;Child Development;Child Health;Child Rearing;Child Support;Child Welfare;Cognitive;Coupled;Data;Demography;Development;diaries;early childhood;Ecology;Education;Employment;Environment;Ethnic Origin;experience;Family;Family member;Family Process;family support;Fertility;Goals;Growth;Head Start Program;Health;High Prevalence;Hour;Household;improved;Income;Instruction;instrument;Investments;Knowledge;labor force participation;Life Cycle Stages;Link;Low income;lower income families;Marital Status;Marketing;Mediating;Mediation;Mediator;meetings;Mentored Research Scientist Development Award;Mentors;Mentorship;Methodology;Methods;middle childhood;Mothers;novel;Nursery Schools;Occupations;Outcome;panel study of income dynamics;Parents;parity;Pathway interactions;Personal Satisfaction;Policies;Poverty;Privatization;programs;Race;Research;Research Activity;Research Infrastructure;Research Institute;Research Personnel;Research Support;Rotation;Sampling;Schedule;Schools;Services;skills;Sleep;Surveys;Techniques;Testing;Time;time use;Training;Training Activity;trend;Universities;Wisconsin;Work

PROJECT_TITLE: Understanding Trends in Mothers' Work Schedules: Implications for Child Health and Development

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Population Sciences Study Section[CHHD-W]


ORG_CITY: CHICAGO

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: NARRATIVE In Mali, the 8th largest African country, a low- and middle-income countries (LMICs) located in West Africa, infection-associated cancers (IACs) are increasing and represent more than a quarter (27%) of all cancers. Few African scientists have the epidemiological, molecular pathology, biostatistics and bioinformatics training needed to design and conduct population-based and mechanistic studies on IACs. This research training program will capitalize on a decade of collaboration between Malian and US investigators to create capacity to develop and implement new contextually appropriate and culturally adaptive strategies to reduce in incidence, morbidity, and mortality of IAC in Mali and other LMICs in the region.

PI_NAMEs: HOU, LIFANG  (contact);MAIGA, MAMOUDOU

PROGRAM_OFFICER_NAME: SIVARAM, SUDHA

PROJECT_TERMS: Address;Africa;Africa South of the Sahara;anti-cancer research;Bioinformatics;Biological Markers;biomarker development;Biometry;cancer epidemiology;Clinical Management;Collaborations;Collection;Data;design;Detection;Diagnostic;Discipline;Doctor of Philosophy;early-career faculty;Education;Educational workshop;empowerment;Epidemiologist;Epidemiology;epidemiology study;experience;Faculty;Funding;global health;Goals;Health system;improved;Individual;Infection;Interdisciplinary Study;Knowledge;Laboratories;Mali;Malignant neoplasm of cervix uteri;Malignant neoplasm of liver;Malignant neoplasm of lung;Malignant Neoplasms;malignant stomach neoplasm;Mentors;Microscopic;Modality;Molecular;Molecular Epidemiology of Cancer;Morbidity - disease rate;mortality;National Cancer Institute;novel;Outcome;Pathologist;Population;population based;Population Study;Populations at Risk;Prevention;programs;Protocols documentation;Public Health;Research Personnel;Research Priority;Research Project Grants;Research Training;Resources;Risk;Risk Factors;risk stratification;Science;Scientist;screening;Screening procedure;skills;Source;specific biomarkers;Specimen;Techniques;Technology;Telepathology;tool;Training;Training Programs;United States National Institutes of Health;Universities;virtual

PROJECT_TITLE: Infection-Associated Cancer Research Training Program in Mali


ORG_CITY: PISCATAWAY

ORG_DEPT: GENETICS

ORG_NAME: RUTGERS, THE STATE UNIV OF N.J.

ORG_STATE: NJ

PHR: PROJECT NARRATIVE Meiosis is an essential stage of egg and sperm formation, errors in which can lead to infertility. Meiotic errors also cause eggs or sperm to have abnormal chromosome numbers, which results in miscarriage or developmental disabilities. This project will address fundamental questions about the mechanisms that regulate meiosis and thus is of direct relevance to human reproductive health and disease.

PI_NAMEs: JAIN, DEVANSHI  (contact)

PROGRAM_OFFICER_NAME: MILLER, RITA K

PROJECT_TERMS: Ablation;Aneuploidy;Behavior;Binding;Birth;Cell Cycle Progression;Cell division;Cells;Cellular biology;chromosome number abnormality;Chromosomes;Complex;Cytoplasm;Developmental Disabilities;Diploid Cells;egg;Failure;Gene Expression;Genetic;Genome Mappings;genome-wide;Germ Cells;Germ Lines;Giant Cells;Haploidy;Human;Infertility;innovation;male;Mammals;Meiosis;Methods;Microscopy;Mitosis;Molecular;Mus;mutant;Pathway interactions;posttranscriptional;Process;programs;Regulation;Reproductive Health;reproductive system disorder;Research;RNA;RNA Helicase;RNA-Protein Interaction;Role;Sexual Reproduction;single cell genomics;sperm cell;Spontaneous abortion;Structure;Testing;transcriptome;Work

PROJECT_TITLE: Regulatory mechanisms of meiotic entry and progression

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


ADMINISTERING_IC: NR

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Asthma;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Networking and Information Technology R&D (NITRD);Pediatric;Prevention;Primary Health Care;Social Determinants of Health

ORG_CITY: Nashville

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: PROJECT NARRATIVE The investigators aim to explore how an informatics resource providing information on social determinants of health (SDoH) may facilitate identification and prevention of asthma exacerbations in school-based health centers. These contributions are expected to be significant because making informatics resources accessible to school-based health providers holds promise for increasing SDoH, further addressing SDoH to decrease asthma exacerbations. The findings of this study will open new horizons on the use of publicly available SDoH data in the unique model of school-based health centers, which are highly relevant to the SDoH and Health Equity research lenses of the National Institute of Nursing Research.

PI_NAMEs: BORKOWSKI, VERA  (contact)

PROGRAM_OFFICER_NAME: MCNAMARA, KAREN MARIE

PROJECT_TERMS: 18 year old;Academy;Address;Affect;Air;Asthma;asthma exacerbation;asthma prevention;asthmatic patient;Awareness;Behavior;biomedical informatics;Caring;Child;Child Care;Childhood;Childhood Asthma;Chronic;Clinical;Communities;cost;dashboard;Data;design;Detection;Development;digital;Discipline of Nursing;Economics;Education;Effectiveness;empowerment;Engineering;Environment;experience;Family;Feedback;Fellowship;Focus Groups;food security;Funding;Future;Geographic Locations;Goals;Health;health care service;health data;health disparity;health equity;Health equity research;Health Expenditures;health inequalities;health knowledge;health outcome disparity;Health Personnel;health service use;housing instability;implementation intervention;improved;Individual;Informatics;information gathering;Intervention;Interview;Knowledge;Knowledge acquisition;Learning;lens;Link;Low Income Population;Machine Learning;Medicine;Mentors;Mentorship;Minority;Mission;Modeling;National Institute of Nursing Research;Neighborhoods;novel;Nurse Practitioners;Nursery Schools;Online Systems;Outcome;Participant;Personal Satisfaction;Persons;Physician Assistants;Physicians;Play;Policies;poor health outcome;Postdoctoral Fellow;Poverty;prevent;Prevention;Preventive care;programs;Provider;Quality of life;Recommendation;Reporting;Research;Research Methodology;Research Personnel;research study;Research Training;Resource Informatics;Resources;responsible research conduct;Role;school based health center;school health;School Nursing;School-Age Population;Schools;screening;Secure;skills;social;Social Behavior;social health determinants;social influence;Strategic Planning;Structure;Technical Expertise;Techniques;Testing;tool;Training;United States National Academy of Sciences;Universities;usability;virtual;Visualization;walkability;Work;Youth

PROJECT_TITLE: Informatics Resources for Social Determinants of Health in School-Based Health Centers

STUDY_SECTION: NRRC

STUDY_SECTION_NAME: Nursing Science Review Committee[NRRC(85)]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Data Science;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: PROVIDENCE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: PROJECT NARRATIVE We propose to use deep learning to integrate multiple genomic datasets and connect them to gene expression. We will develop interpretation methods to extract signals related to misregulated genes in diseases. We will extend these frameworks to single-cell datasets.

PI_NAMEs: SINGH, RITAMBHARA  (contact)

PROGRAM_OFFICER_NAME: GILCHRIST, DANIEL A

PROJECT_TERMS: 3-Dimensional;Automobile Driving;Bayesian Analysis;Biological;Cell Line;Cells;Chromatin;Data;data imputation;Data Set;deep learning;deep learning model;design;Development;Disease;DNA;DNA Methylation;Effectiveness;experimental study;Gene Expression;Gene Expression Regulation;gene repression;Genes;genomic data;Genomic Segment;Goals;Graph;histone modification;improved;insight;interest;Knowledge;Learning;Methods;Modeling;Molecular Conformation;neural network;Noise;novel;repository;Sampling;Signal Transduction;single cell technology;Structure;three-dimensional modeling;tool;Up-Regulation

PROJECT_TITLE: Deep learning for understanding gene regulation in diseases via 'omics' integration


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Cancer Genomics;Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Women's Health Research

ORG_CITY: LEXINGTON

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: Defining roles of succinate in regulating cancer cell plasticity and stemness will fill critical gaps in our knowledge about function of metabolites in breast cancer progression. The study of PLOD2 in regulating cytoplasmic succinate will reveal a novel pathway in succinate regulation; and further evaluating the PLOD2 inhibitor in TNBC xenograft model and PDX models will identify a potential target to halt TNBC progression and metastasis.

PI_NAMEs: XU, REN  (contact)

PROJECT_TERMS: Aftercare;alpha ketoglutarate;Biochemistry;Biological;Biometry;Breast;Breast Cancer Cell;breast cancer metastasis;breast cancer progression;Breast Epithelial Cells;cancer cell;cancer subtypes;cell growth regulation;Cell Membrane Permeability;Cell Physiology;Cells;ChIP-seq;Chromatin;Citric Acid Cycle;Clinical;Collagen;conditional knockout;CpG Islands;crosslink;Cytoplasm;DDR1 gene;Development;Dioxygenases;DNA;Endoplasmic Reticulum;Enzymes;Epigenetic Process;epigenetic regulation;epithelial to mesenchymal transition;Exhibits;experimental study;FDA approved;Fibroblasts;Fibrosis;gain of function;Gene Expression Profiling;Genetic Transcription;Human;Hydroxylation;In Vitro;Incidence;inhibitor;Knockout Mice;Knowledge;Loperamide;loss of function;Lysine;Malignant Breast Neoplasm;Malignant Neoplasms;Mediating;Mesenchymal;Metabolic;metabolomics;mid-career faculty;Modeling;Modification;Molecular;Mouse Mammary Tumor Virus;mouse model;multidisciplinary;Mus;Neoplasm Metastasis;neoplastic cell;novel;Pathologist;Pathway interactions;patient derived xenograft model;Pharmaceutical Preparations;Phenotype;Play;Positioning Attribute;Procollagen;Prognosis;Regulation;Relapse;Repression;Research;Role;Scheme;screening;small hairpin RNA;stable isotope;stemness;Succinates;Testing;therapeutic target;Tissue Sample;Tissues;TP53 gene;transcription factor;transcriptome sequencing;triple-negative invasive breast carcinoma;Weight;Xenograft Model

PROJECT_TITLE: The PLOD2/succinate axis in cancer cell plasticity and stemness

STUDY_SECTION: BCO

STUDY_SECTION_NAME: Biochemical and Cellular Oncogenesis Study Section[BCO]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_NAME: DANA-FARBER CANCER INST

PHR: PROJECT NARRATIVE – OVERALL Prostate cancer is the most common cancer and second leading cause of cancer death for men in the United States. By bringing together basic and clinical investigators across the Dana-Farber/Harvard Cancer Center (DF/HCC) and fostering a research community focused on collaboration and innovation, the DF/HCC Prostate SPORE will address the most important translational research questions and unmet needs in prostate cancer. The three projects take distinct approaches to address the identification and treatment of aggressive prostate cancer, mechanisms of resistance to existing and emerging therapies, and the development of biomarker-driven tailored treatment approaches for patients. These projects will combine biologic studies with patient data to provide new insights into prostate cancer initiation and progression and to develop novel clinical approaches for patients. The DF/HCC Prostate SPORE will also catalyze and enhance interactions within and beyond the DF/HCC that will generate new discoveries, foster diversity, identify future research questions, and promote the next generation of prostate cancer researchers.

PI_NAMEs: BALK, STEVEN P.;BELTRAN, HIMISHA  (contact)

PROGRAM_OFFICER_NAME: SCROGGINS, BRADLEY TODD

PROJECT_TERMS: Acceleration;Acute;Address;androgen independent prostate cancer;Androgen Receptor;anti-cancer research;Autopsy;Back;Basic Science;bench to bedside;Biological;Biological Assay;Biological Markers;biomarker development;biomarker discovery;biomarker driven;Biometry;Blood;Blood specimen;Cancer Biology;Cancer Center;Cancer Etiology;cancer genomics;cancer initiation;career;Caring;Cessation of life;Clinical;Clinical Investigator;Clinical Research;Clinical Sciences;clinical translation;Clinical Trials;cohort;Collaborations;combat;Communication;Communities;Computational Biology;Dana-Farber Cancer Institute;Data;data sharing;Dedications;deep learning;Development;Diagnosis;Disease;Disease Resistance;drug standard;Early Diagnosis;Early treatment;Ensure;Environment;Epigenetic Process;epigenome;EZH2 gene;follow-up;Fostering;Funding;General Hospitals;Genomics;Goals;Growth;high risk;Hospitals;improved;Individual;individualized medicine;Infrastructure;innovation;insight;Institution;Israel;Laboratories;Laboratory Research;Lead;Machine Learning;Malignant neoplasm of prostate;Malignant Neoplasms;Massachusetts;Medical center;meetings;men;Mentors;model development;Molecular;Morbidity - disease rate;mortality;Neoadjuvant Therapy;Newly Diagnosed;next generation;next generation sequencing;novel;novel strategies;Pathology;Pathway interactions;Patient advocacy;patient population;Patients;Phenotype;Population Sciences;pre-clinical;Pre-Clinical Model;precision medicine;precision oncology;preclinical study;Principal Investigator;Prognostic Marker;programs;Prostate;prostate cancer risk;Prostate Cancer therapy;Recruitment Activity;repository;Research;Research Personnel;Resistance;Resistance development;resistance mechanism;Resources;Services;Specimen;success;Therapeutic;therapy resistant;Tissues;Translating;translational approach;translational cancer research;Translational Research;translational scientist;Translations;tumor;tumor progression;United States;Work;Writing

PROJECT_TITLE: DF/HCC Prostate SPORE


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Prostate Cancer;Urologic Diseases

PI_NAMEs: BELTRAN, HIMISHA  (contact)

PROJECT_TERMS: Acceleration;Administrator;Advocate;anti-cancer research;Area;Boston;Cancer Center;career development;Clinical Trials;Collaborations;Communication;Communities;Consent;Dana-Farber Cancer Institute;data sharing;Dedications;Development;Education;Education and Outreach;Enrollment;Ensure;Environment;Ethnic Population;Evaluation Research;Event;Fostering;Funding;Future;Goals;Grant;Human Resources;Individual;Infrastructure;Institution;Lead;Leadership;Link;Malignant neoplasm of prostate;meetings;member;Mentors;Mentorship;Mission;Modification;Monitor;multidisciplinary;outreach;Patient advocacy;Patient Education;patient population;Patients;Pilot Projects;Procedures;programs;Prostate;racial population;Reporting;Reproduction spores;Research;Research Activity;Research Personnel;Resource Sharing;Resources;Schedule;Science;Scientific Advances and Accomplishments;social media;success;symposium;Translational Research;treatment and outcome;Underrepresented Populations;Update;web site;Woman;Work


NIH_SPENDING_CATS: Clinical Research;Genetics;Human Genome;Lung;Machine Learning and Artificial Intelligence;Mental Health;Neurosciences;Precision Medicine;Sleep Research

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Sleep apnea and insomnia, the two most common sleep disorders, are thought to be comprised of distinct subtypes, which remain poorly defined and may contribute differently to the risk of cardiopulmonary, metabolic and psychiatric diseases. Current critical gaps in our understanding and treatment of SA and insomnia include reliable phenotyping of sufficient participants to discover additional genetic associations and identifying clinically diagnosed sleep apnea and insomnia subtypes that lead to increased risk of disease. This project will address these challenges by discovering novel genetic associations with sleep disorders, resolving disease heterogeneity, and helping to clarify the overlap of SA and insomnia with other diseases, with a goal of improving the treatment of heart, lung, blood, and sleep disorders.

PI_NAMEs: CADE, BRIAN EDMAND (contact)

PROGRAM_OFFICER_NAME: BAIZER, LAWRENCE

PROJECT_TERMS: Algorithms;base;Big Data;biobank;burden of illness;case control;Chronic Disease;Classification;Clinical;Clinical Data;clinical diagnosis;cohort;comorbidity;Control Locus;Data;Databases;Diagnosis;Disease;disease heterogeneity;disorder risk;Disparity;endophenotype;ethnic diversity;Foundations;Future;Genes;Genetic;genetic analysis;genetic association;genetic epidemiology;Genetic study;genetic variant;genome wide association study;genome-wide;genomic locus;Goals;Health;Healthcare Systems;Heart Diseases;Hematological Disease;Heritability;Heterogeneity;High Prevalence;Hypoxia;improved;Individual;Intervention;Joints;Knowledge;Lead;Lung Diseases;Machine Learning;machine learning method;Maps;Measures;Medical Records;Mental disorders;Metabolic Diseases;Methods;Minority;multi-ethnic;National Heart, Lung, and Blood Institute;Natural Language Processing;novel;Outcome;Participant;Pathway interactions;Patient Self-Report;patient stratification;patient subsets;Patients;Pattern;Performance;personalized medicine;phenome;Phenotype;phenotypic data;phenotyping algorithm;Physiological;polygenic risk score;Polysomnography;Positioning Attribute;programs;Pulmonary Heart Disease;Research;Risk;risk prediction;Sample Size;Sampling;Sequence Analysis;sex;Site;Sleep;Sleep Apnea Syndromes;Sleep Disorders;Sleeplessness;Testing;tool;Trans-Omics for Precision Medicine;validation studies;whole genome;Woman;working group

PROJECT_TITLE: Genetic Epidemiology of Sleep Apnea and Comorbidities in Biobanks

STUDY_SECTION: CHSA

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology A Study Section[CHSA]


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Prevention;Prostate Cancer;Urologic Diseases

PHR: PROJECT NARRATIVE – PROJECT 1 We propose comprehensive molecular analyses of responding and resistant tumors in a series of neoadjuvant clinical trials of intensive androgen signaling inhibition (ASI) in men with localized high-risk primary prostate cancer. Moreover, we will test the hypothesis that CDK4/6 activation is driving resistance by conducting a phase 2 clinical trial of neoadjuvant intensive ASI (leuprolide plus darolutamide) combined a CDK4/6 inhibitor (abemaciclib).These studies have important biomarker implications for the selection of patients most likely to benefit from intensive ASI, and for determination of mechanisms of resistance, with additional implications for metastatic castration-sensitive prostate cancer.

PI_NAMEs: TAPLIN, MARY ELLEN (contact)

PROJECT_TERMS: abiraterone;Acceleration;Acute;Address;Adjuvant Study;Adjuvant Therapy;Agonist;Androgens;antagonist;Automobile Driving;Biological Markers;Castrate sensitive prostate cancer;Castration;CDK4 gene;clinical efficacy;Clinical Trials;clinically significant;Combined Modality Therapy;Cyclin D1;Dana-Farber Cancer Institute;deprivation;Disease;Disease-Free Survival;disorder risk;efficacy evaluation;enzalutamide;Failure;Genomics;GNRH1 gene;Goals;high risk;improved;In complete remission;inhibitor;insight;Leuprolide;Malignant neoplasm of prostate;Mediating;men;Metastatic Prostate Cancer;Microscopic;Molecular;Molecular Analysis;Neoadjuvant Study;Neoadjuvant Therapy;Newly Diagnosed;non-genomic;novel;novel therapeutic intervention;Oncogenic;Operative Surgical Procedures;Pathologic;patient derived xenograft model;Patient Selection;Patients;phase 3 study;Phase II Clinical Trials;phase II trial;Prediction of Response to Therapy;prevent;Proliferating;Prostate;prostate cancer risk;Radical Prostatectomy;Randomized;Recurrent disease;Relapse;Residual Neoplasm;Residual state;Resistance;resistance mechanism;response;Sampling;Series;Signal Transduction;Specimen;Systemic Therapy;Testing;Translating;tumor;Tumor Biology

PROJECT_TITLE: Efficacy and Mechanisms of Resistance to Neoadjuvant Intensive Androgen Signaling Inhibition


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Data Science;Genetics;Networking and Information Technology R&D (NITRD);Pediatric

ORG_CITY: AMHERST

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

PHR: This Metagenomics Education Partnership will immerse students and teachers within a citizen science research project focusing on assessing waterway health within the Western New York region consistent with the goals of the NIH Science Education Partnership Award (SEPA) R25 program. It will involve a novel third generation sequencing platform to determine the composition of the microbial communities present in those waterways, and to perform complete sequencing of one of the microbial genomes in the sample. The project will promote the role of genomics education in workforce development by informing high school students, educators and other relevant organizations how genomics integrates into future STEM jobs and careers.

PI_NAMEs: KIM, SUNHA ;KOURY, STEPHEN T (contact)

PROGRAM_OFFICER_NAME: FAUPEL-BADGER, JESSICA

PROJECT_TERMS: Area Health Education Centers;Award;Big Data;Bioinformatics;Biological;Biological Sciences;Biotechnology;career;citizen science;Clinical;Collaborations;college;Communities;Computer software;County;Data;Data Set;design;Disadvantaged;disadvantaged student;DNA;DNA sequencing;Education;Education Projects;Educational workshop;empowerment;Evaluation;Event;experience;Faculty;Future;Future Generations;Genbank;Generations;Genetic;Genome;Genomic DNA;Genomics;Goals;Grant;Health;Healthcare;high school;High School Student;interest;Intervention;Laboratories;Learning Skill;Link;medical schools;Metagenomics;Methods;microbial;microbial community;microbial composition;microbial genome;Microbial Genome Sequencing;microbial genomics;Microbiology;Mission;nanopore;New York;novel;Occupations;Organism;Output;Ownership;Participant;Performance;Population Scientist Supplement (R25);Preparation;Procedures;programs;recruit;Research;Research Project Grants;Resources;Role;routine Bacterial stain;Running;Sampling;school district;Schools;Science;science education;Sequence Analysis;sequencing platform;Stream;Student recruitment;Students;symposium;System;teacher;Teacher Professional Development;Technology;Third Generation Sequencing;Time;tool;Training;Underrepresented Populations;United States National Institutes of Health;Universities;Water;water sampling;Workforce Development

PROJECT_TITLE: The Metagenomics Education Partnership:  Harnessing the Power of Microbial Genome Sequencing and Big Data with High School Students and Teachers.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(56)R]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Breast Cancer;Cancer;Clinical Research;Lung;Lung Cancer;Mental Health;Neurosciences;Prevention;Rehabilitation;Women's Health Research

PHR: PROJECT NARRATIVE Despite significant progress in understanding cognitive change around the time of breast cancer diagnosis and treatment, little is known regarding long-term cognitive trajectories and how these might be impacted by a history of cancer and cancer treatment. The overall goal of this proposal is to collect and analyze cognitive performance data at developmentally meaningful intervals 5-20 years post-treatment in older cancer survivors to determine whether cognitive performance remains stable or instead increasingly declines compared to individuals without a cancer history. We will also examine cognitive trajectories for their association with differential deficit accumulation in survivors compared to controls. This research is significant and innovative because little is known about potentially altered cognitive trajectories and the design and methods proposed will be able to characterize these trajectories and potential association with deficit accumulation.

PI_NAMEs: ROOT, JAMES C (contact)

PROGRAM_OFFICER_NAME: GREEN, PAIGE A

PROJECT_TERMS: Activities of Daily Living;Acute;Address;Aftercare;Age;age acceleration;age related decline;Age Years;Aging;apolipoprotein E-4;Brain;breast cancer diagnosis;Breast Cancer survivor;Cancer Survivor;Cancer Survivorship;cancer therapy;cancer-related cognitive impairment;Cardiovascular Diseases;Clinical;clinically relevant;Cognition;Cognitive;Cognitive aging;cognitive change;cognitive control;Cognitive deficits;cognitive function;cognitive neuroscience;cognitive performance;cognitive reserve;cognitive testing;cohort;Collection;comorbidity;comparison control;Data;design;Development;Diagnosis;Discrimination;Disease;DNA;drivers of aging;Education;Enrollment;Ethnic Origin;frailty;Goals;human old age (65+);Impaired cognition;improved;indexing;Individual;innovation;Intervention;longitudinal design;Malignant Breast Neoplasm;Malignant Neoplasms;Masks;Measures;Medical;Methods;Neurocognitive;Neuropsychology;Obesity;Outcome;Pattern;Performance;Phase;Polypharmacy;psychologic;Psychometrics;psychosocial;Race;Recording of previous events;recruit;remote administration;remote assessment;remote delivery;Research;Research Personnel;response;Risk Factors;Saliva;Sampling;Small Business Innovation Research Grant;Smoking;social;Survivors;therapy design;Time;Toxic effect;treatment effect;United States National Institutes of Health;Work

PROJECT_TITLE: Cognitive aging in long-term breast cancer survivors

STUDY_SECTION: NAME

STUDY_SECTION_NAME: Neurological, Aging and Musculoskeletal Epidemiology Study Section[NAME]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Brain Disorders;Childhood Injury;Down Syndrome;Intellectual and Developmental Disabilities (IDD);Pediatric;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Wound Healing and Care

ORG_CITY: COLLEGE STATION

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: TEXAS A&M UNIVERSITY

ORG_STATE: TX

PHR: Project Narrative  DS patients experience low bone mineral density and are at increased risk of fracture. The proposed research will investigate the bone healing response in DS using mouse models of DS to study tissue and bone injury repair, and will determine the extent to which prostaglandin signaling, known to enhance bone formation and crucial for wound healing, may be disrupted in mouse models of DS. These studies will provide crucial information regarding the extent of compromised regeneration in DS and determine whether treatment with known pro-inflammatory and wound healing agents are able to correct the impaired bone and wound healing in murine DS model(s).

PI_NAMEs: SHERMAN, KIRBY M. (contact)

PROGRAM_OFFICER_NAME: BARDHAN, SUJATA

PROJECT_TERMS: Adult;Affect;Agonist;Amputation;Attenuated;Body System;bone;Bone Density;bone fracture repair;bone healing;bone health;Bone Injury;bone mass;Bone Regeneration;bone repair;Bone Resorption;bone turnover;Chromosome 21;Clinical;Congenital Abnormality;Data;Dermal;digit regeneration;Digit structure;Dinoprostone;Distal;Down's Syndrome;EP4 receptor;Event;Exhibits;experience;experimental study;Fibroblasts;Fracture;fracture risk;Frequencies;Genetic Diseases;Harvest;healing;histological stains;Human;Human Chromosomes;Immune;Immune response;Immunohistochemistry;Impaired wound healing;Impairment;improved;in vivo;infection risk;Inflammation;Inflammation Mediators;Inflammatory;Injury;injury and repair;insight;Knowledge;Laboratories;Length;Live Birth;long bone;Lymphangiogenesis;Lytic;Lytic Phase;Macrophage;male;microCT;Modeling;Monitor;mouse model;mouse Ts65Dn;Mus;Natural regeneration;novel;old mice;Osteogenesis;Patient Care;Patients;Phalanx;Pharmacologic Substance;Phase;Phenotype;Play;Population;Process;Prostaglandin E Receptor;Prostaglandins;PTGS2 gene;receptor;recruit;regenerative;Regenerative response;repaired;Reporting;Research;response;response to injury;Risk;Role;Signal Transduction;Spinal Fractures;Testing;Time;tissue injury;tissue repair;Tissues;Trisomy;WFDC2 gene;wound;wound closure;wound healing;X-Ray Computed Tomography

PROJECT_TITLE: Investigating injury response and bone regeneration in Down syndrome mouse models


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Orphan Drug;Prostate Cancer;Rare Diseases;Urologic Diseases

PHR: PROJECT NARRATIVE – PROJECT 2 We recently discovered a novel interaction between the enhance of zeste homolog 2 (EZH2) and DNA repair processes in castration resistant prostate cancer (CRPC) and a synergy between EZH2 and PARP inhibition. In this project, we will elucidate the mechanisms by which EZH2 regulates DNA repair, define how DNA repair pathways impact EZH2 drug sensitivity, and understand the biologic impact of EZH2 plus PARP inhibition across the heterogenous spectrum of CRPC. We will conduct a first -in-field combination EZH2 plus PARP inhibitor therapy clinical trial with extensive translational /biomarker correlates. Results from this project will provide the basis for a new therapeutic strategy for men with CRPC.

PROJECT_TERMS: Acute;Adenocarcinoma;advanced disease;advanced prostate cancer;androgen independent prostate cancer;Androgen Receptor;Automobile Driving;Biological;Biological Markers;biomarker identification;Biopsy;Castration;Cells;Chromatin;Classification;Clinical;Clinical Data;Clinical Research;Clinical Trials;cofactor;Combined Modality Therapy;Complex;Dana-Farber Cancer Institute;Data;Dependence;derepression;Development;Disease;DNA Damage;DNA Methylation;DNA Repair;DNA Repair Gene;DNA Repair Pathway;drug sensitivity;Enhancers;Epigenetic Process;epigenomics;Epithelioid Sarcomas;FDA approved;Gene Expression Profile;gene repair;gene repression;Genomics;Heterogeneity;Histone H3;histone methylation;Homologous Gene;homologous recombination;homologous recombination deficiency;inhibitor;inhibitor therapy;insight;Lysine;Malignant neoplasm of prostate;Measures;Mediating;Medical;member;men;Mesothelioma;Methylation;Modeling;Molecular;neoplastic cell;neuroendocrine phenotype;Neuroendocrine Prostate Cancer;Neurosecretory Systems;Non-Hodgkin's Lymphoma;Nonhomologous DNA End Joining;novel;novel therapeutic intervention;overexpression;PARP inhibition;patient derived xenograft model;patient subsets;Patients;pharmacodynamic biomarker;Phase I/II Clinical Trial;Phenotype;Phosphorylation;Play;Poly(ADP-ribose) Polymerase Inhibitor;Polycomb;preclinical study;Process;programs;Prostate;Prostate Adenocarcinoma;prostate cancer model;prostate cancer progression;Prostate Cancer therapy;Receptor Signaling;Regulation;Repression;Repressor Proteins;Research Personnel;Resistance;response;response biomarker;Role;Route;safety assessment;Signal Transduction;synergism;synovial sarcoma;targeted treatment;Therapy Clinical Trials;therapy duration;therapy resistant;Transcription Repressor;tumor;tumor growth

PROJECT_TITLE: Molecular Determinants of Response and Resistance to EZH2 and PARP inhibition in Prostate Cancer


NIH_SPENDING_CATS: Aging;Atherosclerosis;Bioengineering;Biomedical Imaging;Cardiovascular;Clinical Research;Data Science;Heart Disease;Heart Disease - Coronary Heart Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention

ORG_CITY: STANFORD

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE We seek to develop new deep learning algorithms to utilize already-acquired abdominal computed tomography scans and pair them with a patient’s electronic medical records to predict the risk of future cardiovascular disease. Unlike traditional risk prediction techniques, our proposed tools utilize quantitative imaging measures of multiple tissues related to cardiovascular health as well as a patient’s prior clinical history. If successful, our algorithms could be used to explain a patient’s risk status to their clinician and ultimately, could be used to screen and intervene in millions of patients from diverse backgrounds who are unaware of their risk for heart disease.

PI_NAMEs: BANERJEE, IMON ;CHAUDHARI, AKSHAY  (contact);RODRIGUEZ, FATIMA

PROGRAM_OFFICER_NAME: FLEG, JEROME L

PROJECT_TERMS: 3-Dimensional;Abdomen;abdominal CT;Accident and Emergency department;Address;Adipose tissue;Adult;Affect;Algorithms;American;Aorta;Atherosclerosis;automated segmentation;Black Box;Body Composition;bone;burden of illness;calcification;Cardiology;cardiometabolic risk;cardiometabolism;Cardiovascular Diagnostic Techniques;Cardiovascular Diseases;cardiovascular disorder prevention;cardiovascular disorder risk;cardiovascular health;Cardiovascular system;Cessation of life;Classification;Clinic;Clinical;cohort;comorbidity;Computed Tomography Scanners;Computerized Medical Record;contrast enhanced computed tomography;cost;Data;Data Set;deep learning;deep learning algorithm;deep learning model;Detection;digital twin;Early Diagnosis;early screening;efficacious treatment;Eligibility Determination;Ensure;Equation;Equity;Ethnic Origin;Event;Exhibits;Future;Goals;health equity;heart disease risk;high risk;Image;imaging study;improved;innovation;Insurance;Intervention;Label;lifestyle intervention;Liver;Measures;Medical Imaging;Methods;Modeling;Morbidity - disease rate;Morphologic artifacts;mortality;multimodal data;multimodal modeling;multimodality;Muscle;Myocardial Infarction;Myocardial Ischemia;Patient risk;patient stratification;patient subsets;Patients;Performance;pharmacologic;Phenotype;Pilot Projects;Population;Population Heterogeneity;predictive modeling;prevent;Primary Prevention;Protocols documentation;Quality Control;quantitative imaging;Race;Radiation;radiologist;Radiology Specialty;Reader;Recommendation;Recording of previous events;Risk;Risk Estimate;risk prediction;Scanning;segmentation algorithm;self supervised learning;Site;socioeconomics;statistics;Stroke;stroke event;Subgroup;success;supervised learning;Techniques;Testing;Three-Dimensional Imaging;Tissues;tool;Training;training data;Uncertainty;Validation;Variant;Vascular calcification;Work;X-Ray Computed Tomography

PROJECT_TITLE: Opportunistic Atherosclerotic Cardiovascular Disease Risk Estimation at Abdominal CTs with Robust and Unbiased Deep Learning

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]


ORG_CITY: BALTIMORE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: 1.1 Project Narrative: Overall The mission of the University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center (UMGCCC) is to undertake innovative basic and clinical and population research that will impact the understanding and treatment of cancer around the world and to provide state-of-the-art clinical care to cancer patients in Maryland and beyond.

PI_NAMEs: OWONIKOKO, TAOFEEK K (contact)

PROGRAM_OFFICER_NAME: BELIN, PRECILLA L

PROJECT_TERMS: acronyms;Affect;anti-cancer research;Asian population;Award;Baltimore;Basic Science;Behavior;biobank;Biology;Biometry;Cancer Biology;cancer care;Cancer Center;Cancer Center Support Grant;cancer health disparity;Cancer Patient;cancer therapy;Catchment Area;Cigarette;Cities;Clinic;Clinical;clinical care;clinical phenotype;Clinical Research;clinical training;Clinical Trials;clinically relevant;college;Communities;community based research;Comprehensive Cancer Center;County;Dentistry;design;Detection;Discipline of Nursing;Doctor of Medicine;Education;Ethnic Origin;Faculty;First Independent Research Support and Transition Awards;Flow Cytometry;fundamental research;Funding;Future;Genomics;Grant;Head Cancer;health disparity;hormone related cancer;Human;Image;innovation;Investigational Therapies;Investments;Laboratories;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant Neoplasms;Maryland;Medical;Medical center;medical schools;member;Middle School Student;Minority;minority communities;Minority Groups;Mission;Molecular;Molecular Biology;mortality;multidisciplinary;Names;National Cancer Institute;Neck;neoplasm immunotherapy;news;Participant;Pathology;Patient Care;Patient Participation;Patients;Pharmacy facility;Pharmacy Schools;Population;Population Research;Population Sciences;Positioning Attribute;prevent;Prevention;Prevention Research;Prevention strategy;programs;Public Health Schools;racial diversity;Reporting;Research;Research Activity;Research Design;Research Personnel;School Dentistry;School Nursing;Schools;science education;Screening for cancer;Services;standard of care;structural biology;Structure;Students;System;Talents;Therapeutic;Therapeutic Trials;Training;Translational Research;Translations;tumor immunology;tumor registry;Underrepresented Minority;Universities;virology;Work

PROJECT_TITLE: UNIVERSITY OF MARYLAND GREENEBAUM CANCER CENTERSUPPORT GRANT

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


NIH_SPENDING_CATS: Aging;Bioengineering;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Precision Medicine;Prostate Cancer;Urologic Diseases

PHR: PROJECT NARRATIVE – PROJECT THREE Determination of the coordinated molecular and histopathologic features underlying diverse clinical states is critically needed to enable molecularly guided therapeutic strategies and biologically grounded predictive models for patients with localized prostate cancer who undergo surgery. We are developing biologically- guided artificial intelligence algorithms to understand the molecular and histopathologic features that distinguish key clinical outcomes in this context. This project will guide the convergence of artificial intelligence with translational prostate cancer research to enable precision oncology strategies for this patient population.

PI_NAMEs: VAN ALLEN, ELIEZER M (contact)

PROJECT_TERMS: Address;Adjuvant;Adjuvant Study;advanced disease;anti-cancer research;Architecture;Artificial Intelligence;artificial intelligence algorithm;Binding;Biological;Biological Markers;Cancer and Leukemia Group B;cancer care;cancer genomics;cancer type;candidate validation;Cessation of life;Characteristics;Clinical;clinical biomarkers;Clinical Data;clinical predictive model;clinical prognostic;clinical translation;Clinical Trials;cohort;Complex;computer science;Computer Vision Systems;Dana-Farber Cancer Institute;Data Analyses;deep learning;deep learning model;Development;digital;digital pathology;Disease;DNA Repair;DNA Repair Gene;Event;explainable artificial intelligence;Future;Genetic Transcription;genome-wide;Genomics;Germ Lines;Germ-Line Mutation;high risk;high risk men;Histopathology;hormone therapy;Image;Immune;imprint;improved;Indolent;innovation;Learning;Localized Disease;Malignant neoplasm of prostate;Mediating;Medical Oncology;men;Methodology;Modeling;Molecular;molecular modeling;Molecular Profiling;molecular subtypes;Mutation;Neoplasm Metastasis;neural network;novel;novel therapeutics;Operative Surgical Procedures;Outcome;Outcome Measure;Pathologic;Pathologist;Pathway interactions;patient population;Patients;Pattern;Phase;Phenotype;phenotypic data;point of care;precision oncology;predictive modeling;prognostic;prognostic model;prognostic performance;progression risk;Property;Prostate;prostate cancer model;prostate cancer risk;Radiation;Radiation therapy;Radical Prostatectomy;Recurrence;Recurrent disease;Relapse;Retrospective cohort;Risk;Risk Factors;Somatic Mutation;Specimen;standard of care;survival outcome;Techniques;Therapeutic;Tissues;translational potential;treatment strategy;tumor;Urologic Oncology

PROJECT_TITLE: Dissecting and Predicting Lethal Prostate Cancer using Biologically Informed Artificial Intelligence


NIH_SPENDING_CATS: Cancer

PI_NAMEs: CULLEN, KEVIN J. (contact)

PROJECT_TERMS: acronyms;Address;Agreement;anti-cancer research;Area;Award;Baltimore;biobank;Biometry;Budgets;Cancer Center;Cancer Center Support Grant;Catchment Area;Cigarette;Clinical;clinical practice;Clinical Research;college;Communication;community advisory board;community engagement;Community Outreach;Comprehensive Cancer Center;computer network;Contracts;County;Data Analyses;Development;Doctor of Medicine;Education;Education and Outreach;Ensure;Equipment;Evaluation;Faculty;Flow Cytometry;Fostering;Funding;Genomics;Grant;hormone related cancer;Human;Human Resources;Image;Informatics;Information Technology;Infrastructure;innovation;Institution;Interdisciplinary Study;Investigational Therapies;Laboratories;Leadership;Location;Malignant Neoplasms;Marketing;Maryland;Medical;Medical center;medical schools;meetings;member;Mentors;Mission;Molecular Biology;Monitor;neoplasm immunotherapy;Pathology;Pharmacy Schools;Pilot Projects;population based;Population Sciences;Principal Investigator;Process;programs;Public Health Schools;Recommendation;recruit;Reporting;Research;Research Activity;Resources;School Dentistry;Science;Services;square foot;State Government;Strategic Planning;structural biology;Surveys;symposium;System;Training;Training and Education;translational cancer research;Translational Research;tumor immunology;Universities;virology;Vision;Wages

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Bioengineering;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Networking and Information Technology R&D (NITRD);Urologic Diseases

PI_NAMEs: TYEKUCHEVA, SVITLANA  (contact)

PROJECT_TERMS: Animals;Area;Award;Biometry;Cancer Center;career;Clinical;Clinical Research;Collaborations;Computational Biology;Computer software;computing resources;Consultations;Correlative Study;cost effective;Data Analyses;Data Collection;data integrity;data management;Databases;design;Development;Ensure;epidemiology study;experience;Genomics;Goals;high standard;Laboratories;Libraries;Outcome;programs;Prostate;quality assurance;Reporting;Research;Research Activity;Research Design;Research Personnel;Resource Sharing;Software Design;Translational Research;Writing

PROJECT_TITLE: Biostatistics/Computational Core


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Heart Disease;Lung;Nutrition;Pulmonary Hypertension

ORG_CITY: AMES

ORG_NAME: MTI BIOTECH, INC.

ORG_STATE: IA

PHR: NARRATIVE Based on existing literature and clinical trials, 2-hydroxbenzylamine (2-HOBA) has clear impact on mechanisms that much of the international field of pulmonary hypertension (PH) research agrees are central to disease progression. Our preliminary data and Phase I studies demonstrate not only clear positive impact on reducing pulmonary vascular resistances in Group I and II PH, and both cytokine and molecular biomarkers of disease, but also indicated the potential for a substantial positive effect on heart function under load stress. In this Phase II project, we will test the safety and efficiacy of 2-HOBA in PH patients, improving function of the right ventricle under stress in a large animal model, and effectiveness in the context of standard-of-care in mouse models and large animals, to establish the remaining data needed to proceed to commercialization.

PI_NAMEs: RATHMACHER, JOHN A (contact);WEST, JAMES D

PROGRAM_OFFICER_NAME: SUTLIFF, ROY L

PROJECT_TERMS: Acetylation;adduct;Affinity;Aftercare;Agreement;ambrisentan;analog;Animal Model;Animals;Binding;Biological Markers;Blood;blood vessel occlusion;BMPR2 gene;Cardiac;Cardiac Output;Case Study;CCL4 gene;Cells;Ceramides;Cessation of life;Clinical Trials;Combined Modality Therapy;commercialization;cytokine;Data;Deacetylase;Defect;Disease;Disease Progression;drug efficacy;Echocardiography;Effectiveness;effectiveness testing;EFRAC;Endothelin Receptor Antagonist;Etiology;Event;Fatty acid glycerol esters;fatty acid oxidation;Fatty Acids;Feedback;functional improvement;Genetic;glucose metabolism;Glutamine;Heart;heart function;High Fat Diet;Human;human disease;Hypoxia;improved;in vivo;inhibitor;Insulin Resistance;International;Intervention;Life;Lipids;Literature;Longevity;loss of function;Lung;lung pressure;Lysine;Metabolic;Metabolic Marker;Metabolic syndrome;Mitochondria;Modeling;Molecular;molecular marker;mouse model;Mus;mutant;Mutant Strains Mice;Mutation;Nature;novel strategies;novel therapeutics;open label;Participant;Patients;Phase;phase 1 study;Physiological;pilot trial;primary endpoint;Prostaglandins I;Protein Acetylation;Proteins;Publishing;Pulmonary Hypertension;Pulmonary Vascular Resistance;Reactive Oxygen Species;Research;response;right ventricular failure;right ventricular remodeling;Right ventricular structure;Risk;Safety;safety testing;sheep model;small molecule;standard of care;Stress;success;tadalafil;Testing;Toxic effect;treatment effect;Treprostinil;trial design;uptake;Vasodilator Agents;Walking;Work

PROJECT_TITLE: 2-HOBA for Treatment of Pulmonary Hypertension


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: SEATTLE

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

ORG_STATE: WA

PHR: The University of Washington CFRTC focuses its research on developing new and improved treatments for patients with Cystic Fibrosis and understanding the impact of these new therapies on patient heath. The Center has a long history of strong partnerships between laboratory and clinically based scientists working together to take observations from the laboratory and transforming these findings into better therapies to treat the nutritional, digestive, metabolic and lung aspects of CF. The CFRTC has 3 biomedical cores (Genomic, Host-Microbe, and Clinical), a pilot and feasibility program, and enrichment programs to encourage research collaborations.

PI_NAMEs: GOSS, CHRISTOPHER HOOPER (contact);SINGH, PRADEEP K

PROGRAM_OFFICER_NAME: EGGERMAN, THOMAS L

PROJECT_TERMS: Adult;Affect;age group;Aging;Area;base;Basic Science;Biological;Biometry;care burden;Center for Translational Science Activities;Child;Chronic;Clinical;clinical effect;clinical phenotype;Clinical Research;clinical translation;Collaborations;comparative;Creativeness;Cystic Fibrosis;cystic fibrosis mouse;cystic fibrosis patients;cystic fibrosis related diabetes;Cystic Fibrosis Transmembrane Conductance Regulator;Data;Dentistry;design;Development;Direct Costs;Disease;dissemination research;Doctor of Philosophy;drug development;Exocrine pancreas;FDA approved;Functional disorder;Funding;Future;genome sciences;Genomics;Genotype;Germ-Free;Goals;Grant;Growth;gut microbiome;Health;improved;Industry;infancy;Inflammation;Infrastructure;innovation;insight;Institution;interest;International;Intestinal Diseases;Islets of Langerhans;Kidney;kidney fibrosis;Laboratories;Leadership;Link;Lung;Malignant neoplasm of gastrointestinal tract;Measures;medical schools;Medicine;member;Mentors;Metabolic;Methods;Microbe;Microbiology;mid-career faculty;National Institute of Diabetes and Digestive and Kidney Diseases;next generation;novel;novel therapeutic intervention;novel therapeutics;nutrition;Nutritional;Observational Study;Outcome Measure;Pathogenesis;Patients;Pediatrics;Pharmaceutical Preparations;Pharmacy facility;Phenotype;Physiological;Physiology;Population;Process;professor;programs;Public Health;Recording of previous events;Research;Research Design;Research Institute;Research Personnel;Resources;Risk;Schools;Science;Scientist;Specimen;Statistical Methods;Strategic vision;Symptoms;Training;translational pipeline;Translational Research;treatment effect;Universities;Vision;VX-770;Washington;Work

PROJECT_TITLE: Cystic Fibrosis Translational Research in the Post-CFTR Modulator Era


NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Immunotherapy;Precision Medicine;Urologic Diseases

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative This study aims to advance understanding of adjunctive cryoablation’s ability to increase checkpoint inhibitor response by identifying biomarkers predictive of response as well as mechanisms of resistance. Biomarkers will be identified in preclinical murine models with the aid of granzyme B PET imaging and also identified from clinical biopsy specimens obtained from a prospective clinical trial of cryoablation and pembrolizumab in metastatic urothelial carcinoma. This study will help to define which cancer patients on immunotherapy are most likely to benefit from the addition of cryoablation and how resistance to adjunctive cryoablation can be overcome.

PI_NAMEs: WEHRENBERG-KLEE, ERIC  (contact)

PROGRAM_OFFICER_NAME: LIM, SUSAN E

PROJECT_TERMS: Ablation;Active Sites;Adaptive Immune System;Affect;anti-tumor immune response;Antigens;Applications Grants;Biological Markers;biomarker identification;Biopsy Specimen;Blood;Blood specimen;Cancer Patient;Carcinoma;career;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Death;Cell membrane;Cell Physiology;Cells;checkpoint inhibition;checkpoint therapy;Clinical;clinical development;Clinical Protocols;Clinical Research;Clinical Trials;Cryosurgery;cytokine;Data;Dendritic cell activation;Dendritic Cells;Development;Disease;effector T cell;Eligibility Determination;Ensure;Environment;Flow Cytometry;Freezing;Future;Genomics;Granzyme;Image;imaging agent;Immune;Immune checkpoint inhibitor;Immune response;Immunity;immunogenic;Immunologic Factors;Immunologic Techniques;Immunology;Immunooncology;Immunotherapy;Implant;improved;improved outcome;In complete remission;Inflammation;Inflammatory;inhibitor therapy;Innate Immune System;insight;Interventional radiology;invention;Mediating;Mentors;Modeling;mouse model;Mus;Mutation;Necrosis;Neoplasm Metastasis;neoplastic cell;non-genomic;Patients;pembrolizumab;Positron-Emission Tomography;pre-clinical;pre-clinical research;preclinical study;predicting response;predictive marker;programmed cell death protein 1;prospective;Protocols documentation;Reaction;Regimen;Research;research clinical testing;Resistance;resistance mechanism;responders and non-responders;response;response biomarker;Route;Rupture;single-cell RNA sequencing;Site;skills;success;T-Lymphocyte;Techniques;Testing;Therapeutic;Time;tool;Transitional Cell Carcinoma;tumor;Tumor Antigens;Tumor Markers;tumor-immune system interactions;Urothelium;Variant;Work

PROJECT_TITLE: Biomarker Identification to Increase Adjunctive Cryoablation and Checkpoint-Inhibitor Immunotherapy Response

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


PI_NAMEs: ANTALIS, TONI M (contact)

PROJECT_TERMS: acronyms;American Cancer Society;analytical tool;anti-cancer research;Assessment tool;Baltimore;Basic Science;biobank;Biological Sciences;Biometry;Cancer Biology;Cancer Control;Cancer Diagnostics;cancer education;cancer therapy;career;career development;Career Mobility;Catchment Area;Cigarette;Cities;Clinical;clinical care;Clinical Research;college;Communities;community engagement;Community Outreach;Comprehensive Cancer Center;Continuing Education;County;Databases;Discipline;Doctor of Philosophy;doctoral student;Education;Educational Activities;experience;Faculty;Fellowship;Flow Cytometry;frontier;Funding;Genomics;Goals;Grant;high school;hormone related cancer;Image;Individual;Infrastructure;innovation;Institution;Investigational Therapies;Journals;junior high school;Laboratories;Leadership;Malignant Neoplasms;Maryland;Medical;medical schools;member;Mentors;Minority-Serving Institution;Mission;Molecular Biology;multidisciplinary;National Cancer Institute;NCI Center for Cancer Research;neoplasm immunotherapy;next generation;Oncology;Outcome;outreach;Pathology;Pharmacy Schools;Physicians;Population Sciences;Postbaccalaureate;Postdoctoral Fellow;pre-doctoral;Prevention Research;programs;Publications;Research;Research Activity;Research Personnel;Research Training;Schools;Scientist;Series;Services;Stream;structural biology;Students;synergism;System;Talents;Training;Training and Education;Training Programs;Translational Research;tumor immunology;undergraduate student;underrepresented minority student;Underrepresented Students;United States National Institutes of Health;Universities

PROJECT_TITLE: Cancer Research Training and Education Coordination


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Networking and Information Technology R&D (NITRD);Prostate Cancer;Urologic Diseases

PI_NAMEs: POMERANTZ, MARK M. (contact)

PROJECT_TERMS: Acceleration;Animal Model;Antibodies;Award;Bar Codes;biobank;Biocompatible Materials;Biological Assay;Biological Specimen Banks;Biometry;Biopsy;Blood;cancer Biomedical Informatics Grid;Cancer Center;Cancer Patient;career;Cellularity;Clinical;Clinical Data;clinical database;Collection;Computational Biology;Computer-Assisted Image Analysis;Confidentiality of Patient Information;Consent;Dana-Farber Cancer Institute;Data;Data Analyses;Data Collection;Data Management Resources;Databases;Development;DNA;Ensure;Equipment and supply inventories;Evaluation;experimental study;Formalin;Freezing;Future;General Hospitals;Goals;Hospitals;Human;human model;human tissue;Imaging technology;Immunofluorescence Immunologic;Immunohistochemistry;Infrastructure;Institution;Israel;laser capture microdissection;Link;Malignant neoplasm of prostate;Massachusetts;Medical center;Molecular;Molecular Analysis;mouse model;neoplastic;novel;Outcome;Paraffin Embedding;Pathologic;Pathology;Patients;Performance;Pre-Clinical Model;Procedures;Process;programs;Prostate;Prostatectomy;Prostatic Neoplasms;Proteins;Protocols documentation;Public Health Schools;Quality Control;Research Personnel;Research Project Grants;Resources;RNA;sample collection;Sampling;Secure;Services;Shipping;Slide;Specimen;Stains;Standardization;success;System;Technology;tissue fixing;Tissue Microarray;Tissue Model;Tissues;tool;Translational Research;tumor;Validation;Woman;Work

PROJECT_TITLE: Biospecimen Core


ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: Relevance / Narrative Gastric dysmotility is a pervasive problem in critical illness that results in significant morbidity and mortality. There are knowledge gaps regarding the mechanisms for gastric dysmotility in this cohort. This proposal exam- ines a novel mechanism for gastric dysmotility in critical illness which will impact clinical outcomes for this co- hort by advancing the development of new therapies.

PI_NAMEs: MARTINEZ, ENID E. (contact)

PROGRAM_OFFICER_NAME: SASLOWSKY, DAVID E

PROJECT_TERMS: Advanced Development;Affect;Alleles;career;Caring;Categories;Clinical;clinical translation;cohort;Critical Care;Critical Illness;Critically ill children;diagnostic biomarker;dysbiosis;Education;Endotoxins;Enteral;Enteric Nervous System;Environment;Epithelium;experience;Exposure to;gastrointestinal;Gastrointestinal Physiology;Goals;Grant;gut microbiome;host microbiome;Immunology;improved;Inflammation;Inflammatory;inhibitor;Injections;intestinal epithelium;Intestines;Knowledge;Lipopolysaccharides;Macrophage;Macrophage Activation;Mediating;Mentors;microbial products;microbiome;microbiome alteration;microbiome composition;microbiota;Modeling;Morbidity - disease rate;mortality;Motility;motility disorder;mouse model;Mucous Membrane;multidisciplinary;Mus;novel;novel diagnostics;novel therapeutics;Operative Surgical Procedures;Outcome;Patient Recruitments;patient subsets;Patients;Phenotype;Physicians;Postoperative Period;Proteins;Protocols documentation;Research;Research Personnel;Scientist;Secondary to;skills;Stomach;System;systemic inflammatory response;Therapeutic;therapeutic target;therapy development;trafficking;Transgenic Mice;translational approach;Translational Research;Transplant Recipients;Transplantation;United States National Institutes of Health;Up-Regulation;Wild Type Mouse;Work;zonulin

PROJECT_TITLE: Evaluating the effect of zonulin-mediated intestinal trafficking on gastrointestinal macrophages and their function on gastric motility

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


NIH_SPENDING_CATS: Arthritis;Chronic Pain;Clinical Research;Fibromyalgia;Neurosciences;Pain Research

ORG_CITY: IOWA CITY

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF IOWA

PHR: Project Narrative Fibromyalgia is difficult to diagnose and treat with current approaches based primarily on symptoms. The primary goal of this proposed research is to assess and validate candidate metabolic biomarkers to diagnose fibromyalgia and evaluate the relationships between metabolic biomarkers and fibromyalgia symptoms. These studies will provide results for development of potential diagnostic tests and therapeutic biomarkers to improve outcomes for individuals with fibromyalgia.

PI_NAMEs: FREY LAW, LAURA A;SCHREPF, ANDREW ;SLUKA, KATHLEEN A (contact)

PROGRAM_OFFICER_NAME: WANG, YAN Z

PROJECT_TERMS: 6-phosphogluconate;Address;Aerobic;Affect;associated symptom;Basic Science;Biological;Biological Markers;biosignature;Blood specimen;candidate marker;candidate validation;Carpal Tunnel Syndrome;Cellular Metabolic Process;Cerebrospinal Fluid;chronic pain;chronic painful condition;Citric Acid;Clinical;Clinical Trials;cohort;Cohort Studies;Complex;Cysteine;Data;Data Collection;Degenerative polyarthritis;design;Development;Diagnosis;Diagnostic;diagnostic criteria;Diagnostic tests;disability;Disease;disease phenotype;Early treatment;Energy Metabolism;Evaluation;Fatigue;Fibromyalgia;Fumarates;Funding;Goals;Human;Hydration status;Hydrogen;improved;improved outcome;Individual;inflammatory pain;Institution;intervention effect;Investigation;Magnesium;Malate Dehydrogenase;Malates;Metabolic;Metabolic Pathway;metabolomics;Michigan;multidisciplinary;Nicotinamide adenine dinucleotide;novel;open label;Oxaloacetates;oxidation;Pain;painful neuropathy;Pathogenicity;Patient Self-Report;Patients;Phenotype;phenotypic data;Physical Function;Physicians;Plasma;Population;potential biomarker;Primary Fibromyalgias;Process;Production;Proteomics;Psychological Factors;Research;Rheumatoid Arthritis;ROC Curve;Role;Sampling;Secondary Fibromyalgias;Sensitivity and Specificity;Severity of illness;Site;Sleep;Sleep Disorders;specific biomarkers;Specificity;Symptoms;Testing;Therapeutic;therapeutic biomarker;therapeutic target;United States National Institutes of Health;Universities;Woman

PROJECT_TITLE: Metabolic Biomarkers for Fibromyalgia