NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Social Determinants of Health;Violence Against Women;Violence Research;Women's Health Research;Youth Violence

ORG_CITY: BLOOMINGTON

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: TRUSTEES OF INDIANA UNIVERSITY

ORG_STATE: IN

PHR: 8. Project Narrative Well-being in adulthood depends on having an adequate social life and a network of people who can help when they are needed. Decisions and experiences during the transition to adulthood—especially with romantic partners—may have a long-term influence on adult well-being. This project proposes to use existing data to characterize young adulthood experiences with romantic partners, and to collect new data about established adulthood well-being from those same respondents ten years later, to see how those experiences are linked over time.

PI_NAMEs: BARBER, JENNIFER S. (contact)

PROGRAM_OFFICER_NAME: POPKIN, RONNA

PROJECT_TERMS: 19 year old;Adolescent;Adult;adverse childhood events;Age;age difference;Agreement;assault;Calendar;Cessation of life;Child;Conflict (Psychology);County;Data;data reduction;Data Set;Data Sources;Decision Making;Development;Disadvantaged;disadvantaged background;disadvantaged women;Disparity population;Electronic Mail;experience;Family;Family Relationship;fighting;Friends;Funding;Future;Generations;Goals;Health;high risk;Impairment;Imprisonment;innovation;interest;Interview;Left;Life;Life Cycle Stages;Link;Longitudinal Surveys;maltreatment;Measures;Mental Health;Methods;Michigan;Modeling;Mothers;National Institute of Child Health and Human Development;older women;Pattern;penis;Personal Satisfaction;Persons;physical conditioning;Pilot Projects;Poverty;Pregnancy;pregnant;Probability;Psyche structure;Random Allocation;Recontacts;Recording of previous events;Research;Respondent;Role;Sampling;Sequence Analysis;sex;Sexuality;social;social engagement;social inclusion;social relationships;Social support;Subgroup;substance use;Surveys;Techniques;Testing;Text;theories;Thick;Time;transition to adulthood;Update;Vagina;Victimization;Violence;violent relationship;Woman;Work;young adult;young woman

PROJECT_TITLE: Intimate Relationship Dynamics and Social Health from Early to Established Adulthood

STUDY_SECTION: SSPB

STUDY_SECTION_NAME: Social Sciences and Population Studies B Study Section[SSPB]


ADMINISTERING_IC: AI

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Infectious Diseases;Sexually Transmitted Infections

ORG_CITY: PULLMAN

ORG_COUNTRY: UNITED STATES

ORG_DEPT: VETERINARY SCIENCES

ORG_FIPS: US

ORG_NAME: WASHINGTON STATE UNIVERSITY

ORG_STATE: WA

PHR: Herpes simplex viruses cause cold sores and sexually transmitted infections, and can also cause the serious complications of neonatal infections, blindness, and fatal encephalitis. The purpose of this research is to determine how the herpes simplex virus initiates infection in humans by studying the virus interaction with host cell lipids. Greater understanding of the virus entry process will help to identify novel approaches to prevent herpes infections.

PI_NAMEs: NICOLA, ANTHONY V (contact)

PROGRAM_OFFICER_NAME: DUPUY, LESLEY CONRAD

PROJECT_TERMS: Address;Anabolism;Biochemical;Biological;Biological Assay;Blindness;Cell Line;Cell membrane;Cell-Matrix Junction;Cells;Chimeric Proteins;Cholesterol;Complex;Data;Development;Disease;Encephalitis;Endocytosis;Endocytosis Pathway;Engineering;Epithelial Cells;Epithelium;Event;experience;experimental study;genital infection;Goals;Herpes Labialis;Herpesviridae;Herpesviridae Infections;Human;human pathogen;Infection;inhibitor;innovation;insight;Intervention;Knowledge;Laboratories;latent infection;Lipid Bilayers;Lipids;Mammalian Cell;Membrane;Membrane Fusion;Membrane Lipids;Membrane Microdomains;Membrane Proteins;Molecular;Molecular Conformation;Morbidity - disease rate;mortality;Mutation;Nature;neonatal infection;Neurons;novel;novel strategies;pathogen;Pathway interactions;Penetration;pharmacologic;Physiological;Play;Population;prevent;Process;Proteins;Publishing;Reducing Agents;Research;Role;Route;Sexually Transmitted Diseases;Simplexvirus;Sphingolipids;Sphingomyelins;trafficking;uptake;Vaccines;vesicle transport;Viral;viral envelope lipids;Virion;Virus;virus envelope;Virus-Cell Membrane Interaction

PROJECT_TITLE: Membrane sphingomyelin and HSV entry

STUDY_SECTION: MCV

STUDY_SECTION_NAME: Molecular and Cellular Biology of Virus Infection Study Section[MCV]


ADMINISTERING_IC: HG

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: SYRACUSE

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UPSTATE MEDICAL UNIVERSITY

ORG_STATE: NY

PHR: PROJECT NARRATIVE  Our proposed project centers on understanding how chromosomes undergo breakage during replication stressful conditions in the normal human genomes. We propose to map high resolution chromosome fragile sites in the normal human genome with a newly upgraded technology named Fragile Site(FS)-Seq to facilitate discoveries of underlying causal factors for genome instability.

PI_NAMEs: FENG, WENYI  (contact)

PROGRAM_OFFICER_NAME: CHADWICK, LISA

PROJECT_TERMS: Address;Aphidicolin;cell type;Cells;Chemicals;Chromosome Fragile Sites;Chromosomes;Conflict (Psychology);Coupled;Cytology;Detection;detection method;Disease;DNA;DNA biosynthesis;DNA Damage;DNA Double Strand Break;DNA Polymerase Inhibitor;DNA Probes;DNA Sequence Alteration;DNA Single Strand Break;Effectiveness;Etiology;Event;Excision;Fluorescent in Situ Hybridization;Fragile X Syndrome;Genes;Genetic Transcription;Genome;genome-wide;genome-wide analysis;Genomic Instability;Goals;Hot Spot;Human;Human Cell Line;human disease;Human Genome;Laboratories;Lesion;lymphoblastoid cell line;Malignant Neoplasms;Mammalian Chromosomes;Maps;Metaphase;Methodology;Methods;Mutation;Names;Nervous System Disorder;next generation sequencing;Nucleotides;Pathway interactions;Persons;Procedures;Recurrence;Regulation;Replication Initiation;replication stress;Research Proposals;Resolution;response;Signal Transduction;Single-Stranded DNA;Site;Stains;Stress;Techniques;Technology;technology platform;Testing;Time;Tissues;tool;wound

PROJECT_TITLE: Mechanisms of Chromosome Fragile Site Formation in the Human Genome

STUDY_SECTION: MG

STUDY_SECTION_NAME: Molecular Genetics Study Section[MG]


NIH_SPENDING_CATS: Autoimmune Disease;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Inflammatory Bowel Disease;Liver Disease;Rare Diseases

ORG_CITY: SALT LAKE CITY

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: RELEVANCE Several inflammatory diseases are linked to the intestine, including primary sclerosing cholangitis (PSC), an immune-mediated disease hallmarked by liver fibrosis. There is no therapy that prevents PSC from getting worse, and liver transplant is the only cure—although sometimes, PSC can return even after liver transplant. This project will offer specific cell types for targeted approaches to treat diseases linked to the intestine, including PSC-linked liver fibrosis, an unstoppable disease that has no cure.

PI_NAMEs: HAMMER, GIANNA ELENA (contact)

PROGRAM_OFFICER_NAME: HUDSPETH, KELLY

PROJECT_TERMS: Abdomen;Animal Model;Area;Attenuated;Automobile Driving;Biliary;cell motility;cell type;Cells;Cholangitis;Cholestasis;comorbidity;Data;Dendritic Cells;Disease;disease model;driving force;Emigrant;Emigrations;Fibrosis;gut inflammation;gut-liver axis;Health;high reward;high risk;Histologic;Histopathology;Human;Immigrant;Immune;Inflammation;Inflammatory;Inflammatory Bowel Diseases;innovation;Intestinal Diseases;Intestines;IRF4 gene;Label;langerin;Learning;Lifting;Light;Link;Liver;Liver diseases;Liver Fibrosis;liver injury;liver transplantation;Lung;lymph nodes;Mediating;Methods;Migrant;migration;Modeling;mouse model;Mus;Necrosis Induction;novel;novel strategies;Operative Surgical Procedures;Organ;pathogen;Pathogenesis;Pathologic;Pathology;Poison;Population;prevent;primary sclerosing cholangitis;Process;Publishing;radiologist;Role;Susceptibility Gene;Testing;Therapeutic;Therapeutic Intervention;Tissues

PROJECT_TITLE: Cellular mechanisms linking the intestine to inflammation involving non-intestinal organs

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


NIH_SPENDING_CATS: Cancer;Coronaviruses;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Immunotherapy;Infectious Diseases;Opioids;Prevention;Vaccine Related

ORG_CITY: PITTSBURGH

ORG_DEPT: DERMATOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Narrative Our discovery of an unexpected adjuvant pathway (targeting KOR) to modulate a pro-vaccination skin immune microenvironment for enhancing induction of pathogen and tumor antigen-specific T cell and antibody responses against infectious disease and cancer would lead to a novel KOR-selective small molecule agonist adjuvanted skin vaccination with the high translational potential.

PI_NAMEs: YOU, ZHAOYANG  (contact)

PROGRAM_OFFICER_NAME: JOFFE, AARON MICHAEL

PROJECT_TERMS: Adjuvant;Agonist;antagonist;Antibody Response;antigen-specific T cells;Antigens;Antiinflammatory Effect;Autoimmune;Biological Assay;Blood;Breast Cancer Model;CCL3 gene;CD8-Positive T-Lymphocytes;chemokine;Chickens;Chronic;Clinic;Clinical;Clinical Trials;Collection;Communicable Diseases;Cross-Priming;cytokine;cytokine release syndrome;Data;Dendritic Cells;Dose;Endotoxins;Gene Expression;Human;Immunization;In Vitro;Infiltration;Inflammatory;Inflammatory Response;Interferon Type II;Interferons;Intramuscular;irritation;kappa opioid receptors;keratinocyte;Licensing;Malignant Neoplasms;Melanoma;MF59;microbial;Modeling;mouse model;Mus;Needles;neutralizing antibody;novel;novel vaccines;Oncogenic Viruses;Opioid agonist;Ovalbumin;pathogen;Pathway interactions;Pharmaceutical Preparations;Phase;Property;Proteins;Receptor Activation;response;SARS-CoV-2 immunity;SARS-CoV-2 spike protein;screening;Site;Skin;skin disorder;skin vaccination;small molecule;T-Cell Activation;T-Lymphocyte;TLR2 gene;TLR4 gene;TNF gene;translational potential;tumor;Tumor Antigens;Tumor Immunity;tumor-immune system interactions;United States National Institutes of Health;Vaccinated;Vaccination;Vaccine Adjuvant;vaccine efficacy;Vaccines;Viral Antigens;Vitiligo;XCL1 gene

PROJECT_TITLE: A Novel Vaccine Adjuvant KOR-selective Small Molecule Agonist

STUDY_SECTION: VID

STUDY_SECTION_NAME: Vaccines Against Infectious Diseases Study Section[VID]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_CITY: MOUNT PLEASANT

ORG_NAME: CENTRAL MICHIGAN UNIVERSITY

ORG_STATE: MI

PHR: NARRATIVE Sensing and controlling inflammatory activity is critical for understanding brain function in health and disease. However, current methodologies are limited in their ability to noninvasively image and manipulate specific cellular functions, specifically manipulating inflammatory states dependent on the activation of a kinase of interest involved in the inflammatory process. The goal of this proposal is to develop novel indicators and genetic circuits that will address limitations of current technologies to enable non-invasive reporting of inflammatory state and dynamic control over inflammatory processes in genetically defined cell types in the brain as a tool to treat various inflammatory diseases.

PI_NAMEs: BAKKE, JESSE LEE;PETERSEN, ERIC DAVID;ROSSIGNOL, JULIEN  (contact)

PROGRAM_OFFICER_NAME: ATANASIJEVIC, TATJANA

PROJECT_TERMS: Acids;Affinity;Alzheimer's Disease;Animal Model;Animals;Anti-Inflammatory Agents;Area;Astrocytes;Automobile Driving;Autopsy;Binding;Biological Process;Bioluminescence;Biosensor;Blood coagulation;Brain;Cell Physiology;cell type;Cells;Cerebellum;Cessation of life;Chronic;Cognition Disorders;cognitive function;combat;cytokine;design;Dimerization;Disease;Engineering;experience;experimental study;Explosion;Family;Feedback;Fluorescence;Fluorescence Resonance Energy Transfer;Gene Expression;Gene Expression Profiling;Gene Expression Regulation;Genes;Genetic;Genetic Transcription;Goals;Health;high throughput screening;Hippocampus;Histologic;Huntington Disease;Immune system;Immunology;immunoregulation;improved;in vivo;Inflammation;Inflammatory;Inflammatory Response;Informal Social Control;inhibitor;innovation;interest;Interleukin-10;Interleukin-6;Libraries;Light;light emission;Link;Luciferases;luciferin;Malignant Neoplasms;marine organism;Measurement;Methodology;Methods;Microglia;Monitor;mouse model;multidisciplinary;Myocardial Infarction;Nerve Degeneration;Neurodegenerative Disorders;neuroinflammation;Neurosciences;non-invasive imaging;novel;optogenetics;overexpression;Parkinson Disease;Pathologic;Pathology;Performance;Pharmacologic Substance;Phosphorylated Peptide;Phosphorylation;Phosphotransferases;Play;Process;Production;Property;Proteins;reconstitution;Reporter;Reporter Genes;Reporting;Research;Resolution;response;Role;screening;sensor;side effect;Signal Transduction;single cell sequencing;Specificity;Stimulus;Stroke;Structure;Synthetic Genes;System;Technology;Testing;Therapeutic;Time;Tissues;tool;transcription factor;Transgenic Mice;Transgenic Organisms;Translating;translational potential;Variant

PROJECT_TITLE: Genetic circuits for targeted modulation of neuroinflammation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-B (80)]


ADMINISTERING_IC: HD

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Brain Disorders;Clinical Research;Neurosciences;Physical Injury - Accidents and Adverse Effects;Rehabilitation;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_DEPT: MISCELLANEOUS

PHR: PROJECT NARRATIVE Rehabilitation for people with persisting symptoms of imbalance and dizziness after concussion focuses on improving one’s ability to integrate sensory signals for balance control. However, daily life also requires a cognitive application of this sensory integration to remember one’s position and navigate through the environment. This project will use state-of-the-art virtual reality technology and tests of dynamic sensory integration during navigation and balance to determine the effects of concussion on spatial navigation to guide targeted rehabilitation strategies.

PI_NAMEs: CREEM-REGEHR, SARAH H;FINO, PETER C (contact)

PROGRAM_OFFICER_NAME: NITKIN, RALPH M

PROJECT_TERMS: Address;Affect;Attention;Brain Concussion;Caring;Clinical;clinical translation;Cognitive;cognitive performance;cognitive task;cost;Cues;Darkness;Dizziness;Environment;Equilibrium;Exhibits;flexibility;foot;Functional disorder;functional improvement;Future;Goals;Impairment;improved;improved mobility;Independent Living;Injury;innovation;Knowledge;Life;Link;Location;Maps;Measures;member;Modeling;Motion;Motor;Patient Self-Report;Patients;Perception;Performance;Peripheral;persistent symptom;Persons;Positioning Attribute;Postural adjustments;Process;rehabilitation strategy;Rehabilitation therapy;rehabilitative care;Research;Resources;Role;Sensory;sensory integration;Signal Transduction;spatial integration;Symptoms;Technology;Testing;United States;Update;Vestibular dysfunction;vestibular system;virtual reality;Visual;Walking;way finding;Work

PROJECT_TITLE: Sensory Integration for Spatial Navigation After Concussion

STUDY_SECTION: MFSR

STUDY_SECTION_NAME: Motor Function, Speech and Rehabilitation Study Section[MFSR]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Diabetes;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences

ORG_CITY: DURHAM

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE  This Exploratory/Developmental Research Grant proposal seeks to advance the state of the art in diagnostic ophthalmic imaging with a novel, robotically-aligned optical coherence tomography system capable of automatically measuring a retinal biomarker that cannot currently be reliably identified with standard of care OCT devices. The research is directed towards developing an automatic method for measuring this biomarker without the need for a trained operator and demonstrating its use in a clinical setting. We believe our technology will allow for increased access to a new diagnostic for monitoring patients with major retinal diseases.

PI_NAMEs: KUO, ANTHONY NANLIN;TOTH, CYNTHIA ANN (contact)

PROGRAM_OFFICER_NAME: LEE, PAEK-GYU

PROJECT_TERMS: Accounting;Adoption;Animal Model;Anterior;Applications Grants;Atrophic;Biological Markers;Blindness;Blood Vessels;Cells;Clinic;Clinical;clinical biomarkers;Compensation;Computer software;Contralateral;Custom;Data;design;Development;Devices;Diabetes Mellitus;Diabetic Angiopathies;Diabetic Retinopathy;Diagnostic;diagnostic biomarker;Disease;disorder of macula of retina;Exhibits;Eye;Fiber;Future;Goals;Human;Image;imaging capabilities;improved;in vivo;Individual;Inherited;invention;Lateral;Manuals;Maps;Measurement;Measures;meter;Methods;Monitor;Motion;Nerve Degeneration;Neurons;new technology;novel;novel diagnostics;Nuclear;Ophthalmology;Optical Coherence Tomography;Optics;Outcome;Patient Monitoring;Patients;Pattern;photoreceptor degeneration;Photoreceptors;Pilot Projects;Population;Positioning Attribute;Prevalence;Prevention;Process;Pupil;Radial;Reporting;Reproducibility;Research;Research Project Grants;Resolution;Retina;Retinal Diseases;retinal imaging;Retinal Photoreceptors;Robotics;Role;Sampling;Scanning;Side;software development;standard of care;System;Techniques;Technology;Testing;Thick;Thinness;Time;tool;Training;United States National Institutes of Health;Visualization

PROJECT_TITLE: Robotic OCT for automated mapping of outer retinal layer thicknesses

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-P (81)]


NIH_SPENDING_CATS: Aging;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: NEW HAVEN

ORG_DEPT: PHARMACOLOGY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Public Health Relevance Statement: Neutrophils are the most common type of white blood cell in the human body and help the immune system fight infections and heal injuries. This study intends to establish a new system to screen novel regulators for the development and short lifespan of neutrophils. Our study may provide a powerful tool for investigating neutrophil biology and pinpoint new therapeutic targets for treating neutrophil-related inflammatory diseases.

PI_NAMEs: TANG, WENWEN  (contact)

PROJECT_TERMS: Acute;Acute Lung Injury;Adhesions;Apoptosis;Bacterial Infections;Biological Models;Biology;cell motility;Cell Physiology;Cells;Cessation of life;Chemotactic Factors;Chemotaxis;Chimeric Proteins;Clustered Regularly Interspaced Short Palindromic Repeats;Coupled;CRISPR/Cas technology;cytokine;Dedications;Development;differentiation in vitro;directional cell;Disease;Elements;extracellular;fighting;Genes;Genetic;Genetic Screening;genome wide screen;Goals;Half-Life;healing;hematopoietic stem cell differentiation;Hematopoietic stem cells;Human body;Immune response;Immune system;In Vitro;in vivo;Individual;Infection;Infiltration;Inflammation;Inflammatory;Injury;insight;interest;Investigation;Knock-in Mouse;Knowledge;Laboratories;Lentivirus;Leukocytes;Libraries;life span;Methods;Microbe;mouse model;Mus;neutrophil;new therapeutic target;next generation sequencing;novel;Pathway interactions;Phagocytosis;Physiology;Play;Production;public health relevance;Reactive Oxygen Species;recruit;Refractory;Regulation;Reperfusion Injury;Reporting;Research;response;Role;Sampling;screening;Signal Pathway;Signal Transduction;Site;System;Techniques;Time;Tissues;tool;Toxic Neutrophil;transcription factor;Transfection;Validation;Viral;Work

PROJECT_TITLE: Identification of Novel Regulators for Neutrophil Development and Lifespan

STUDY_SECTION: III

STUDY_SECTION_NAME: Innate Immunity and Inflammation Study Section[III]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Clinical Research;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Prevention;Substance Misuse

ORG_CITY: HADLEY

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF MASSACHUSETTS AMHERST

ORG_STATE: MA

PHR: Project Narrative  This application aims to develop a portable device for early detection of HIV (human immunodeficiency virus) with finger-prick (or heel-prick) blood samples in a minimally-invasive way. This portable device will allow for rapid, accurate, sensitive, on-site, self-testing by untrained individuals to detect HIV within less than two weeks of post-infection in a resource-limited setting.

PI_NAMEs: WU, NIANQIANG  (contact)

PROGRAM_OFFICER_NAME: ESPY, NICOLE JOY

PROJECT_TERMS: 2-arachidonylglycerol;3-Dimensional;Acquired Immunodeficiency Syndrome;Adult;Antibodies;Antibody Response;antibody test;antigen detection;Antigens;Biological Assay;Biology;Blood;Blood specimen;Blood Tests;Cessation of life;Clinic;Clinical;clinical diagnosis;Clinical Sensitivity;Communities;community clinic;Consumption;Data;design;Detection;detection limit;Development;Device or Instrument Development;Devices;Diagnosis;Diagnostic;Diagnostic Reagent Kits;Early Diagnosis;economic cost;Enzyme-Linked Immunosorbent Assay;Exposure to;fabrication;FDA approved;Fingers;Fluorescence;Foundations;Generations;global health;Goals;Guidelines;Health;Heel;HIV;HIV Antibodies;HIV diagnosis;HIV Infections;HIV Seropositivity;HIV-1;Home;Human immunodeficiency virus test;Immune system;Impairment;improved;Individual;Infant;Infection;Intervention;Laboratories;Lateral;Liquid substance;Measurement;Measures;Medical;Medicine;Methods;Microfluidics;minimally invasive;Morbidity - disease rate;mortality;multidisciplinary;nanoarchitecture;Nanostructures;novel;Nucleic Acid Amplification Tests;Outcome;Paper;Patients;Performance;Persons;Phase;Plasma;plasmonics;point of care;point of care testing;portability;programs;protein biomarkers;Protocols documentation;Public Health;quality assurance;rapid detection;Reader;reproductive tract;Research;Resource-limited setting;RNA;Sampling;scale up;self testing;Sensitivity and Specificity;sensor;Site;skills;Statistical Data Interpretation;Statistical Models;Structure;synthetic polymer Bioplex;test strip;Testing;Time;tool;transmission process;Validation;Viral Load result;Virus;Whole Blood;Work

PROJECT_TITLE: A Portable Fluorescence Lateral Flow Device for Self-Testing of HIV

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 JBS-A (S1)]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Emerging Infectious Diseases;Genetics;Infectious Diseases;Microbiome;Vector-Borne Diseases;Women's Health Research

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative Intracellular microbes such as pathogens, symbionts, and mitochondria have profound impacts on animal physiology and health, but there is limited functional understanding of what factors regulate interaction and inheritance of the intracellular community. This research will use insect models combined with a suite of molecular tools and multiplex fluorescent microscopy to define how intracellular infections establish and evolve stable associations with other co-inherited microbes. The simplicity and tractability of this model will inform our understanding of intracellular communities in far more complex systems, particularly those that impact human health.

PI_NAMEs: LINDSEY, AMELIA RYAN ISIS (contact)

PROGRAM_OFFICER_NAME: COSTERO-SAINT DENIS, ADRIANA

PROJECT_TERMS: Address;Alphaproteobacteria;Anaplasma;Animal Model;Animals;Arthropod Vectors;Arthropods;Bacteria;Biology;Cell Line;Cell Lineage;Cells;Cellular biology;Clinical;co-infection;Communities;Complex;Culicidae;Data;Development;Disease;Drosophila genus;dysbiosis;Ehrlichia;endosymbiont;Eukaryotic Cell;Evolution;Excision;Failure;Fluorescent Dyes;Fluorescent in Situ Hybridization;Generations;Germ Lines;Goals;gut microbiome;Health;high throughput analysis;Home;host-associated microbial communities;host-microbe interactions;Human;human pathogen;Immunity;improved;Individual;Infection;Inherited;Insecta;interest;Knowledge;live cell imaging;Maintenance;Mediating;Metabolism;Methods;Microbe;microbial;microbial community;Microscopy;Mitochondria;Mitochondrial Diseases;Modeling;Molecular;Molecular Biology;Nematoda;offspring;Oogenesis;Organelles;Ovary;Parents;pathogen;Pattern;Phenotype;Physiology;Planet Earth;Planets;Play;Population;programs;Publishing;Reproduction;reproductive;Research;Resources;Rickettsia;Sampling;secondary infection;Site;spatiotemporal;Stains;success;symbiont;Symptoms;System;Techniques;therapeutic development;timeline;tool;transcriptome;transgenerational epigenetic inheritance;transmission process;Variant;vector control;vector management strategies;vector-borne pathogen;Vectorial capacity;Vertical Transmission;Wolbachia;Work

PROJECT_TITLE: Mechanisms facilitating microbial co-inheritance

STUDY_SECTION: GVE

STUDY_SECTION_NAME: Genetic Variation and Evolution Study Section[GVE]


NIH_SPENDING_CATS: Biotechnology;Immunization;Infectious Diseases;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention;Vaccine Related

ORG_CITY: NEW YORK

ORG_DEPT: PEDIATRICS

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: PROJECT NARRATIVE A vaccine to prevent congenital transmission of human cytomegalovirus (HCMV) infection is needed to significantly reduce birth defects and brain damage caused by this most common congenital infection, yet a vaccine that can elicit potent immune responses and effectively prevent infection during pregnancy remains elusive. Fc-mediated antibody effector responses have been implicated in prevention of placental HCMV transmission, but HCMV encodes proteins (viral FcγRs) to evade this key immune response; thus, this proposal will employ novel strategies to target viral FcγRs through active vaccination to modify current vaccine strategies with the goal of yielding stronger responses that will impact CMV transmission.

PI_NAMEs: PERMAR, SALLIE R. (contact)

PROJECT_TERMS: Active Immunization;adaptive immunity;Adjuvant;Affect;Amino Acid Receptors;Amino Acid Sequence;Animal Model;Animals;Antibodies;Antibody Response;antibody-dependent cell cytotoxicity;antibody-dependent cellular phagocytosis;Antigens;B-Lymphocytes;Binding;Blood;Brain Injuries;Cell membrane;Chronic;Clinical;Collection;Combined Vaccines;Complex;Congenital Abnormality;congenital cytomegalovirus;congenital infection;cytokine;Cytomegalovirus;Cytomegalovirus Infections;Cytomegalovirus Vaccines;cytotoxicity;Defect;detection assay;Development;Emulsions;Epithelial Cells;experience;Fc Receptor;Fibroblasts;Globulins;Glycoproteins;Goals;hearing impairment;Human;Immune;Immune Evasion;immune function;Immune response;Immune Targeting;Immunity;Immunization;Immunize;immunogenicity;Immunoglobulin G;Immunologic Factors;Impairment;improved;in utero;In Vitro;in vivo;Individual;infant infection;Infection;Infection prevention;Licensing;Measures;Mediating;MF59;Modeling;Modification;Neurologic;Newborn Infant;novel strategies;Oryctolagus cuniculus;peptide B;Peptides;Peripheral Blood Mononuclear Cell;Placenta;Plasma;preclinical evaluation;Pregnancy;prevent;Prevention;Protein Complex Subunit;Protein Subunits;Proteins;rational design;receptor;Receptor Inhibition;receptor vaccine;Research;response;Risk;Role;seropositive;Species Specificity;Squalene;Stains;Subunit Vaccines;success;T cell response;Testing;Time;transmission process;Vaccination;Vaccine Antigen;Vaccine Clinical Trial;vaccine development;vaccine efficacy;vaccine strategy;Vaccines;Vertical Transmission;Viral;Woman;Work

PROJECT_TITLE: Improving HCMV vaccine-elicited immunity by targeting viral Fc receptors


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Chronic Pain;Pain Research;Physical Injury - Accidents and Adverse Effects

ORG_DEPT: BIOMEDICAL ENGINEERING

PHR: PROJECT NARRATIVE We propose to investigate the complex relationships between the compliance of interbody metamaterial fusion cages, load-sharing, and the progression of spinal fusion in vivo. We hypothesize that the proposed metamaterial interbody cages with local compliance and reduced stiffness foster more consistent load-sharing and lead to a faster bone formation and better fusion. The proposed experimental concept paves the way for the design of next-generation compliant metamaterial orthopedic implants and fixation devices for therapeutics of fracture repair.

PI_NAMEs: ALAVI, AMIR  (contact)

PROGRAM_OFFICER_NAME: BITTMANN, MORIA FISHER

PROJECT_TERMS: 3D Print;absorption;Acceleration;Adult;Affect;Animal Model;Animals;Anterior;Architecture;Arthrodesis;Articular Range of Motion;Biocompatible Materials;biomaterial compatibility;Biomechanics;bone;Bone Formation Stimulation;bone fracture repair;Bone Growth;Cells;Cervical;Cervical spine;Characteristics;Clinical;clinical translation;clinically significant;cohort;Collection;Complex;computer framework;density;design;Devices;digital;digital imaging;Dimensions;Elements;Environment;Experimental Designs;Fatigue;follow-up;Foreign Bodies;Fostering;Future;Height;Histologic;Implant;improved;in vivo;indexing;instrument;Label;manufacture;Mechanics;Methods;microCT;Modeling;Motion;next generation;Operative Surgical Procedures;Orthopedics;Osteogenesis;Outcome;Pain;Porosity;Postoperative Complications;Postoperative Period;pressure;Process;Property;Protocols documentation;rational design;Reporting;response;sample fixation;Series;Sheep;sheep model;simulation;Spinal;Spinal Fusion;success;Testing;Theoretical model;Therapeutic;timeline;United States;Vertebral column;Vertebrates;X-Ray Computed Tomography

PROJECT_TITLE: Investigating the effect of mechanical compliance of metamaterial interbody cages on spinal fusion progress in vivo

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Cancer;Emerging Infectious Diseases;Genetics;Hematology;Infectious Diseases;Regenerative Medicine;Transplantation

ORG_CITY: HOUSTON

ORG_NAME: RICE UNIVERSITY

ORG_STATE: TX

PHR: PROJECT NARRATIVE Pseudomonas aeruginosa causes serious and frequently fatal hospital-acquired infections, particularly in neutropenic patients like those with hematologic malignancies or who are undergoing hematopoietic cell transplantation. High-risk strains, such as ST111, which are associated with increased virulence and antimicrobial resistance, tend to be clinically dominant in these populations, although the causes have remained unclear. Our preliminary data indicate that the dominance of ST111 is driven by two factors which this grant will study: suppression of other P. aeruginosa sequence types by a secreted protein complex and by exploiting quorum-sensing signals secreted by other bacteria.

PI_NAMEs: KIRIENKO, NATASHA  (contact)

PROGRAM_OFFICER_NAME: ERNST, NANCY L

PROJECT_TERMS: Address;Anti-Bacterial Agents;Antibiotic Therapy;Antibiotics;Antimicrobial Resistance;Automobile Driving;Bacteria;Biological;Biological Assay;Blood;Caenorhabditis elegans;carbapenem resistance;Carbapenems;Cells;Centers for Disease Control and Prevention (U.S.);chemotherapy;Clinical;co-infection;Complex;Dangerousness;Data;Death Rate;Defense Mechanisms;Disadvantaged;Disease Outbreaks;Drug resistance;epidemiology study;Ethics;experimental study;fitness;Fluoroquinolones;Gene Modified;Genes;Genetic;Genetic Screening;Genetic Transcription;genome sequencing;Grant;Growth;health care settings;Health Sciences;Hematologic Neoplasms;Hematopoietic Stem Cell Transplantation;high risk;high risk population;Hospitals;human pathogen;Immunocompromised Host;improved;Infection;insight;Knowledge;Longitudinal Studies;Meropenem;Methods;Modeling;Molecular;Morbidity - disease rate;mortality;mutant;Mutation;mutation screening;Nematoda;Nosocomial Infections;O Antigens;Oregon;Outcome;patient population;Patients;Peptides;Pharmaceutical Preparations;Phenotype;Play;Population;Positioning Attribute;prevent;Process;Production;Proliferating;Prophylactic treatment;protein complex;Protein Secretion;Pseudomonas aeruginosa;Pseudomonas aeruginosa infection;Publications;quorum sensing;Recording of previous events;Resistance;resistant strain;Resources;restraint;Role;Sepsis;Signal Pathway;Signal Transduction;skills;Stream;Structural Genes;System;Testing;tool;Transfer RNA;Transplant Recipients;Universities;VDAC1 gene;Virulence;whole genome;Work

PROJECT_TITLE: Molecular mechanisms for clinical dominance of P. aeruginosa ST111 isolates

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IMII-U (01)]


ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: NARRATIVE Inborn errors of immunity (or primary immunodeficiencies) comprise a large, diverse group of inherited genetic defects that can cause a variety of serious human diseases. While these defects are often individually very rare, studies to define their underlying molecular basis can offer an unparalleled opportunity to acquire new fundamental understanding of immune system function. Here, we propose such mechanistic studies of a newly identified, disease-causing variant of an innate immune protein which may ultimately reveal novel aspects of its role in connecting two distinct cellular anti-viral pathways.

PI_NAMEs: CONN, GRAEME L (contact)

PROGRAM_OFFICER_NAME: MORRIS FEARS, MARGARET A

PROJECT_TERMS: Acceleration;Acute;Address;Adenoviruses;Allosteric Regulation;Amino Acid Substitution;Anti-viral Response;Autoimmunity;autoinflammation;Binding;Biological Assay;Bronchiolitis Obliterans;Cell Physiology;Cells;Clinical;Communication;congenital immunodeficiency;Core Protein;Coupled;Cyclic GMP;Defect;Deuterium;Disease;disease-causing mutation;DNA;DNA Viruses;Double Stranded DNA Virus;Double-Stranded RNA;ds-DNA;enzyme activity;Enzymes;Equilibrium;Foundations;Future;gain of function;Genes;Glutamic Acid;Goals;Guanosine Triphosphate;Heterozygote;Human;human disease;Hydrogen;Hypersensitivity;Immune;Immune signaling;immune system function;immunoregulation;In Vitro;Individual;Infection;Inherited;innate immune pathways;insight;Interferons;Investigation;Ligase;Live Birth;lysin;Lysine;Malignant Neoplasms;Mass Spectrum Analysis;Mediating;Membrane Proteins;Missense Mutation;Mitochondria;Modeling;Molecular;Molecular Conformation;molecular dynamics;Monitor;Mutation;Nature;novel;oligoadenylate;Pathway Analysis;Pathway interactions;Patients;Periodicity;Prevalence;Production;programs;Protein Dynamics;protein purification;protein structure;Proteins;Publishing;recurrent infection;Regulation;Research;Ribonucleases;RNA Binding;Roentgen Rays;Role;Sampling;sensor;Signaling Protein;Site;Stimulator of Interferon Genes;Structure;Surface;System;Testing;Tretinoin;Variant;Viral;Virus Diseases;Virus Replication;Work;X-Ray Crystallography

PROJECT_TITLE: New insight into innate immune regulation through mechanistic studies of a novel oligoadenylate synthetase-like (OASL) gain-of-function variant

STUDY_SECTION: MSFB

STUDY_SECTION_NAME: Macromolecular Structure and Function B Study Section[MSFB]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Liver Disease;Nutrition

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because the discovery of novel mechanisms that regulate hepatic and intestinal lipid and glucose metabolism will provide new insights into the pathogenesis and complications of non-alcoholic fatty liver disease. The proposed studies are relevant to the mission of the NIDDK because they are expected to identify new therapeutic strategies for the management of non-alcoholic fatty liver disease.

PI_NAMEs: COHEN, DAVID E. (contact)

PROGRAM_OFFICER_NAME: BURGESS-BEUSSE, BONNIE L

PROJECT_TERMS: absorption;Acetates;Acetyl Coenzyme A;Acetylation;Acyl Coenzyme A;Address;Adipose tissue;Anabolism;Binding;Biological Models;blood glucose regulation;C-terminal;Cell Death;Cell Nucleus;Chylomicrons;Coenzyme A;Cytoplasm;Data;design;Diet;Disease;Enterocytes;Enzymes;Fasting;Fatty Acids;Fatty Liver;Genes;Genetic Transcription;Gluconeogenesis;glucose metabolism;Goals;Grant;Health;Hepatic;Hepatocarcinogenesis;Homeostasis;Hydrolysis;Inflammation;insight;Intervention;intestinal barrier;intestinal epithelium;Intestines;Laboratories;Lecithin;Ligands;Lipid Binding;lipid biosynthesis;lipid metabolism;Lipids;Liver;liver injury;lysophosphatidic acid;Lysophosphatidylcholines;Maintenance;Mediating;member;Membrane;Membrane Lipids;Metabolic;Metabolic Pathway;Metabolism;Mission;Mitochondria;Molecular;Mus;N-terminal;National Institute of Diabetes and Digestive and Kidney Diseases;non-alcoholic fatty liver disease;novel;novel strategies;novel therapeutic intervention;Nutrient;Outcome Study;Overnutrition;oxidation;Pathogenesis;Pathway interactions;phosphatidylcholine transfer protein;Physiological;Play;preservation;prevent;Production;Public Health;Regulation;Research;Research Proposals;response;Role;Signal Transduction;Skeletal Muscle;Small Intestines;steroidogenic acute regulatory protein;Testing;Therapeutic;Thermogenesis;trafficking;transcription factor;Up-Regulation

PROJECT_TITLE: Lipid-Mediated Control of Acetyl-CoA Metabolism in the Pathogenesis of NAFLD

STUDY_SECTION: NMHD

STUDY_SECTION_NAME: Nutrition and Metabolism in Health and Disease Study Section[NMHD]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Complementary and Integrative Health;Emerging Infectious Diseases;Infectious Diseases;Microbiome

ORG_CITY: RALEIGH

ORG_NAME: NORTH CAROLINA STATE UNIVERSITY RALEIGH

PHR: NARRATIVE Fungal infections are difficult to treat because they form biofilms that reduce drug efficacy. These biofilms are also in difficult-to-access locations, such as the gut. We will engineer a probiotic yeast that senses whether a fungal biofilm is present, and if it is, produces drugs to degrade the biofilm.

PI_NAMEs: CROOK, NATHAN C. (contact);JENSEN, EMIL DAMGAARD

PROGRAM_OFFICER_NAME: LIU, BAOYING

PROJECT_TERMS: Adherence;alternative treatment;anti-fungal agents;Bacterial Adhesins;Binding;Binding Proteins;Biological Assay;Biological Response Modifier Therapy;burden of illness;Bypass;Candida;Candida albicans;Candida albicans resistance;Candidiasis;cathelicidin antimicrobial peptide;Cell surface;Cues;Death Rate;delivery vehicle;Disease;Dose;Drug Delivery Systems;drug efficacy;Engineered Probiotics;Engineering;Enzymes;Excision;extracellular;Extracellular Protein;Fungal Drug Resistance;Future;G-Protein-Coupled Receptors;Gentian Violet;Growth;gut colonization;gut microbiota;improved;Individual;Infection;Infection prevention;Large Intestine;Lead;Lipids;Liposomes;Location;Maps;Measures;Microbe;Microbial Biofilms;mouse model;Mucous body substance;Mycoses;nano;Partner in relationship;pathogen;Pathogenicity;Patients;peptide drug;peptide hormone;Peptides;Pharmaceutical Preparations;Pheromone;Pheromone Receptors;Pre-Clinical Model;Predisposition;prevent;Probiotics;promoter;Proteins;receptor;Receptor Signaling;Recombinant Proteins;response;Saccharomyces;Signal Transduction;Site;Specificity;success;Surface;synergism;synthetic peptide;targeted delivery;Testing;Therapeutic;transcriptome;Virulence;Yeasts

PROJECT_TITLE: Precision delivery of antibiofilm therapies using Candida-sensing probiotic yeast

STUDY_SECTION: DBTD

STUDY_SECTION_NAME: Drug and Biologic Therapeutic Delivery Study Section[DBTD]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric

ORG_CITY: PHILADELPHIA

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: DREXEL UNIVERSITY

PHR: PROJECT NARRATIVE ADNP mutations in humans are one of the most common single-gene causes of autism spectrum disorder (ASD). We have recently found that pigment epithelium-derived factor (PEDF) plays a critical role in neurite formation, spine formation, and calcium signaling and that Adnp is a potential downstream effector of PEDF signaling. Therefore, we will investigate whether the PEDF-derived peptide treatment can normalize abnormal neuromorphology and neural connectivity in the Adnp+/- mice.

PI_NAMEs: TOYO-OKA, KAZUHITO  (contact)

PROGRAM_OFFICER_NAME: KISHORE, SANDEEP

PROJECT_TERMS: 17p13.3;Acceleration;Address;Adult;adult with autism spectrum disorder;Affect;American;Amino Acids;Animal Model;autism spectrum disorder;autistic children;Axon;Behavior;Behavior Disorders;Brain;burden of illness;Calcium Signaling;Child;Chromosomes;combinatorial;Communication impairment;Data;Defect;Dendrites;Development;Disease remission;Drug Targeting;effective therapy;Electroporation;Epilepsy;Excitatory Synapse;Fibronectins;Genes;Goals;hippocampal pyramidal neuron;Human;human induced pluripotent stem cells;human model;Image;Impairment;improved;in utero;in vivo;induced pluripotent stem cell;Inhibitory Synapse;interest;Interneurons;Intrabody;Label;Length;Mental Retardation;Miller-Dieker Syndrome;Molecular;Morphogenesis;Morphology;Mus;Mutation;neural;Neurites;Neurodevelopmental Disorder;Neurons;neuroprotection;novel;novel strategies;novel therapeutic intervention;novel therapeutics;Outcome;Patients;Peptides;Persons;Pharmaceutical Preparations;pigment epithelium-derived factor;Play;Population;prenatal;Prevalence;Process;Proteins;Proteomics;Quality of life;reconstitution;reduce symptoms;Regulatory Pathway;repetitive behavior;Research;Retinal Diseases;Role;Signal Pathway;Signal Transduction;Signaling Protein;Slice;social;Social Interaction;symptom treatment;Symptoms;Synapses;synaptogenesis;Syndrome;Techniques;Testing;Therapeutic;tumor;United States;Valproic Acid;Vertebral column

PROJECT_TITLE: Targeting the Pigment Epithelium-Derived Factor (PEDF) Signaling Pathway in Neurodevelopmental Disorders

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BN-P (57)]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Diabetes;Nutrition;Obesity

ORG_CITY: BATON ROUGE

ORG_NAME: LSU PENNINGTON BIOMEDICAL RESEARCH CTR

ORG_STATE: LA

PHR: Communication between fat cells and immune cells is critical to the normal function of fat tissue. In obesity, the ways fat cells respond to immune cells can change, leading to inflammation and dysfunction in fat tissue. Results of these studies will reveal new cell communication patterns that can be leveraged to treat obesity and other metabolic diseases.

PI_NAMEs: ELKS, CARRIE M (contact)

PROGRAM_OFFICER_NAME: BASU, RAJATAVA

PROJECT_TERMS: Acute;Address;Adipocytes;Adipose tissue;antagonist;Attenuated;Automobile Driving;Cell Communication;Cells;Chemotactic Factors;Chronic;Clustered Regularly Interspaced Short Palindromic Repeats;Communication;CXCR4 gene;cytokine;Cytokine Signaling;Data;desensitization;Disease;Doxycycline;energy balance;Exhibits;Fasting;Fatty acid glycerol esters;Functional disorder;Gene Expression Profile;Health;High Fat Diet;Human;Immune;impaired glucose tolerance;Impairment;Inflammation;Inflammatory;Insulin;Insulin Resistance;insulin sensitivity;Knowledge;Lipids;Lipolysis;Macrophage;Metabolic Diseases;Modeling;Mus;mutant;Obese Mice;Obesity;oncostatin M;Paracrine Communication;Pathologic;Pattern;Physiological;Production;Publishing;receptor;receptor binding;receptor internalization;Receptor Signaling;recruit;Regulation;Resistance;response;Role;Signal Induction;Signal Transduction;Small Interfering RNA;Stromal Cell-Derived Factor 1;Testing;Tissues;tool

PROJECT_TITLE: Adipocyte cytokine signaling as a coordinator of adipose tissue function

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 EMS-S (02)]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Physical Injury - Accidents and Adverse Effects;Rehabilitation;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: LOS ANGELES

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: Project Narrative The ability to leverage early biomarker, clinical, and demographic data to accurately predict a patient’s likely recovery trajectory following moderate-to-severe traumatic brain injury (TBI) is paramount to allow definition of appropriate therapeutic strategies and to evaluate medical (as well as ethical and legal) decision-making including withdrawal of life-supporting therapies. Here, we develop, and compare to existing clinical algorithms, two novel strategies that leverage non-parametric models and machine learning techniques to fuse and incorporate routine multimodal and multiplex MR signals into prediction frameworks. Ultimately, this project aims at developing a broadly accessible platform that can be used by practicing clinicians all over the world to supplement prognoses with quantitative and spatial multimodal MR data.

PI_NAMEs: MONTI, MARTIN MAX (contact)

PROGRAM_OFFICER_NAME: DUAN, QI

PROJECT_TERMS: 3-Dimensional;Acute;Address;Adopted;Affect;Age;Algorithms;Architecture;Artificial Intelligence;biomedical imaging;blind;Brain Injuries;Brain Pathology;Caring;Clinical;clinical imaging;clinical practice;clinical prognostic;Collaborations;Coma;convolutional neural network;Data;data fusion;Data Set;Decision Making;Development;Diffusion Magnetic Resonance Imaging;early detection biomarkers;Ethics;evidence base;Family Practice;feature extraction;Functional disorder;functional outcomes;Geographic Locations;Glasgow Coma Scale;Glasgow Outcome Scale;Image;improved;Injury;innovation;Institution;Intensive Care Units;International;Intervention;Joints;large datasets;Legal;Life;Light;Machine Learning;Magnetic Resonance Imaging;Measures;Medical;Medical center;Medical Imaging;Modality;model development;Modeling;Motor;multimodal fusion;Multimodal Imaging;multimodal learning;multimodality;National Institute of Biomedical Imaging and Bioengineering;Neurologic;neurological recovery;novel;novel strategies;Outcome;Patients;Performance;Phase;Physicians;Predisposition;Prognosis;prognostic algorithm;prognostication;Recovery;Recovery of Function;Research;Sampling;Scientific Advances and Accomplishments;Severities;Signal Transduction;Site;socioeconomics;Source;Standardization;TBI Patients;Techniques;Therapeutic;tool;training data;Traumatic Brain Injury;Traumatic Brain Injury recovery;treatment choice;United States National Institutes of Health;United States National Library of Medicine;Validation;Variant;Vertebral column;Withdrawal;Work

PROJECT_TITLE: Predicting recovery after TBI: Development and comparison of MR-supplemented models using non-parametric and machine learning multimodal fusion

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Coronaviruses;Coronaviruses Diagnostics and Prognostics;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Hematology;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: ATHENS

ORG_NAME: UNIVERSITY OF GEORGIA

PHR: As witnessed in Coronavirus disease 2019 (COVID-19) pandemic, inflammation-induced thrombosis could lead to elevated disease severity, worsened clinical outcomes and increased mortality. Due to the high biological safety risk, the blood samples of patients with infectious diseases are limited to access for in vitro experimental investigations of the mechanisms underlying the processes of thrombus formation. In this application, we propose to develop a new predictive multiscale and multiphysics framework enhanced with deep learning techniques to elucidate the connection between the pathogenesis of microthrombosis and the clinical outcomes of patients with COVID-19 and this proposed framework can be extended to test new hypothesis for hyperinflammatory prothrombotic disorders in various infectious diseases.

PI_NAMEs: FRYDMAN, GALIT H.;LI, HE  (contact)

PROGRAM_OFFICER_NAME: GOLDBERG, ILANA GRACE

PROJECT_TERMS: Address;Adverse effects;Autopsy;Biochemical;Biological;Biophysics;Blood;Blood Cells;Blood coagulation;Blood Coagulation Factor;Blood flow;Blood Platelets;Blood specimen;Blood Vessels;Cell model;Cells;Cellular Morphology;Classification;Clinical;Clinical Data;Coagulation Process;Communicable Diseases;Complex;computer framework;Computer Models;COVID-19;COVID-19 pandemic;COVID-19 patient;COVID-19 prognosis;cytokine;Data;deep learning;deep learning model;Disease;Disease Marker;disease model;disease prognosis;Disease Progression;Endothelial Cells;Flow Cytometry;graph neural network;Heart;Hospitalization;Image;Image Cytometry;immunothrombosis;improved;In Vitro;in vivo;Inflammation;Inflammatory;Inflammatory Response;insight;Investigation;Kidney;kinetic model;Knowledge;learning progression;Leukocytes;Link;Liver;Lung;Machine Learning;Membrane Proteins;Microcirculation;Microvascular Dysfunction;Modeling;mortality;multi-scale modeling;Multiple Organ Failure;neural network;novel therapeutic intervention;Organ;Outcome;Output;Pathogenesis;Pathologic;Pathway interactions;patient prognosis;Patient-Focused Outcomes;Patients;Phenotype;Physics;Physiological;Platelet Activation;Play;predict clinical outcome;predictive modeling;Process;Reporting;Risk;Role;Safety;severe COVID-19;Severity of illness;Signal Pathway;simulation;Stains;Systems Biology;targeted treatment;Techniques;Testing;Therapeutic Intervention;thrombogenesis;Thrombosis;thrombotic;Thrombus;Time;tool;United States National Institutes of Health;Work

PROJECT_TITLE: A deep learning-enhanced multiphysics and multiscale framework for predictive modeling of inflammation-induced thrombosis

STUDY_SECTION: MABS

STUDY_SECTION_NAME: Modeling and Analysis of Biological Systems Study Section[MABS]


ORG_CITY: NORMAN

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF OKLAHOMA

ORG_STATE: OK

PHR: Project Narrative Bacteriophages are a threat to human health due to harmful effects on human microbial community as well as due to losses in fermentation industry caused by bacteriophage infections. CRISPR adaptation is the fundamental mechanism by which bacteria fight off phage infection where in a short piece of the intruder genome is sequence specifically inserted into the bacterial genome for offering immune protection. The proposed study will reveal the distinct mechanistic features promoting site-specific DNA insertions from different subgroups of type II- A CRISPR system, the results of which will enable biotechnological and biomedical applications such as programmed DNA insertions, improved phage therapy to fight drug-resistant bacteria, and development of superior bacterial strains for the fermentation industry.

PI_NAMEs: RAJAN, RAKHI  (contact)

PROGRAM_OFFICER_NAME: MALLIA, CONRAD M

PROJECT_TERMS: Active Sites;Amino Acids;Archaea;Automobile Driving;Bacteria;Bacterial Antibiotic Resistance;Bacterial Genome;Bacterial Infections;Bacteriophages;Biochemical;Bioinformatics;Biological Assay;Biomedical Engineering;Biotechnology;Clustered Regularly Interspaced Short Palindromic Repeats;combat;Complex;Data Analyses;design;Deuterium;Development;DNA;DNA Sequence;drug resistant bacteria;ds-DNA;Engineering;Fermentation;fighting;flexibility;Foundations;Free Energy;gene-editing approach;Genetic;Genetic Materials;Genetic Transcription;Genome;Goals;Guide RNA;Health;Human;human microbiota;Hydrogen;Immune;Immune response;improved;Individual;Industry;Infection;interest;Interruption;Mass Spectrum Analysis;Memory;memory retention;Methods;Molecular;Molecular Conformation;molecular dynamics;molecular mechanics;Mutate;non-Native;Nucleic Acids;Nucleotides;Process;promoter;Property;Proteins;Quantum Mechanics;Recurrence;Reporting;Research;RNA;segregation;Side;Site;Specificity;Structure;Subgroup;success;System;Testing;Therapeutic;tool;Translating;Validation;Variant;Work

PROJECT_TITLE: Characterizing mechanisms of immune protection by the bacterial type II-A CRISPR systems

STUDY_SECTION: MSFA

STUDY_SECTION_NAME: Macromolecular Structure and Function A Study Section[MSFA]


ORG_DEPT: PHYSIOLOGY

PHR: Project Narrative: Atherosclerosis is driven by the accumulation of cholesterol in the aortic intima that deposits within “foamy” macrophages present in plaque. We will address the mechanisms that Trem2 uses to promote foamy cell formation through cholesterol uptake, and regulation foamy macrophage lipid metabolism and cholesterol efflux. Finally, we will test a novel therapeutic drug that binds and triggers activation signal through Trem2 for treatment of existing atherosclerotic plaques, knowledge that is necessary for translation of these findings into future patient studies.

PI_NAMEs: WILLIAMS, JESSE WARREN (contact)

PROGRAM_OFFICER_NAME: HASAN, AHMED A  K

PROJECT_TERMS: Address;Adipose tissue;Agonist;Antibodies;Aorta;Arterial Fatty Streak;Arteries;Atherosclerosis;Binding;Blood flow;Cardiovascular Diseases;Cell Death;Cell Differentiation process;Cell Survival;cell type;Cells;Chimera organism;Cholesterol;Chronic;Complement;CRISPR screen;CRISPR/Cas technology;Data;Deposition;Development;Disease;Disease Progression;endoplasmic reticulum stress;experience;experimental study;Exposure to;Foamy Macrophage;FRAP1 gene;Functional disorder;Future;Gene Expression;Gene Expression Profiling;Genes;genome editing;genome-wide;Heart Diseases;high risk;hypercholesterolemia;Immune;improved outcome;In Vitro;in vivo;Infiltration;Inflammatory;Intervention;Ischemia;Knock-out;Knowledge;knowledge translation;Lesion;lipid metabolism;Lipid-Laden Macrophage;Lipids;LXRalpha protein;Macrophage;Maps;Mediating;Metabolic;Metabolic dysfunction;Microglia;Modeling;monocyte;Morbidity - disease rate;mortality;mouse model;Mus;mutant;Myelogenous;Myeloid Cells;Necrosis;novel;novel therapeutics;oxidized low density lipoprotein;Pathway interactions;Patients;Pharmaceutical Preparations;Phenotype;PIK3CG gene;Play;Positioning Attribute;Predisposition;primary outcome;Proliferating;Proto-Oncogene Proteins c-akt;Publishing;recruit;Regulation;Resolution;Risk Factors;Role;Rupture;sensor;Serum;Signal Transduction;single-cell RNA sequencing;Stroke;survival outcome;Tamoxifen;Testing;Therapeutic;therapeutic target;Thrombosis;tool;Translations;TREM2 gene;uptake;Viral

PROJECT_TITLE: Regulation of Foamy Macrophage Differentiation and Survival in Atherosclerosis

STUDY_SECTION: AVI

STUDY_SECTION_NAME: Atherosclerosis and Vascular Inflammation Study Section[AVI]


NIH_SPENDING_CATS: Genetics

ORG_CITY: BETHESDA

ORG_NAME: HENRY M. JACKSON FDN FOR THE ADV MIL/MED

ORG_STATE: MD

PHR: Project Narrative High doses of ionizing radiation cause profound and chronic inflammation in affected tissues and subsequent fibrosis that is related to the activation and altered polarization of macrophages. Radiation impacts macrophages through DNA damage and the activation of aberrant transcription, which both trigger specific intracellular nucleic acid receptors and downstream signaling pathways, resulting in differential expression of type I interferons and inflammatory modulators. In this project we will explore the distinct role of RNA and DNA sensors and their signaling pathways in prolonged radiation-induced inflammatory activation of macrophages and their response to increasing doses of irradiation.

PI_NAMEs: IORDANSKIY, SERGEY  (contact)

PROGRAM_OFFICER_NAME: DICARLO-COHEN, ANDREA L

PROJECT_TERMS: Acute;Adaptor Signaling Protein;Affect;Anti-Inflammatory Agents;Bone Marrow;cell injury;Cell Line;Cells;Chronic;Complex;CRISPR interference;cytokine;Cytoplasm;Data;differential expression;DNA;DNA Damage;DNA strand break;DNA Transposable Elements;Dose;Double-Stranded RNA;Endogenous Retroviruses;Exposure to;Family member;Feedback;Fibrosis;Flow Cytometry;Gamma Rays;Gene Expression;Genes;Genetic Transcription;Goals;Heteroduplex DNA;Human;Hybrids;Hyperactivity;Immune;In Vitro;in vivo;Individual;Inflammation;Inflammation Mediators;Inflammatory;Inflammatory Response;Interferon alpha;interferon alpha receptor;Interferon Type I;Interferon-beta;Interferons;Ionizing radiation;IRF3 gene;irradiation;Knock-out;Knockout Mice;Lead;Lentivirus;Long-Term Effects;Lung;Macrophage;Macrophage Activation;Mediating;Mitochondria;Molecular;monocyte;Mouse Mammary Tumor Virus;Mouse Strains;Mus;new therapeutic target;Nucleic Acids;Outcome Study;Pathologic;Pathway interactions;Pattern;Pattern recognition receptor;Phenotype;Play;Production;Proteins;Radiation;Radiation Dose Unit;Radiation emergency;Radiation exposure;Radiation Induced DNA Damage;Radiation therapy;Radiation-Induced Change;radioresistant;receptor;Recurrence;Regulation;response;Retroelements;RNA;RNA Binding;RNA Helicase;Role;sensor;Signal Induction;Signal Pathway;Signal Transduction;Spleen;STAT1 gene;Stimulator of Interferon Genes;TBK1 gene;Testing;Therapeutic Intervention;therapeutic target;Time;Tissues;translational impact;type I interferon receptor;Up-Regulation

PROJECT_TITLE: RNA and DNA sensors in the response of macrophages to ionizing radiation

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Dental, Oral, and Craniofacial Disease;Social Determinants of Health

ORG_CITY: CHARLESTON

ORG_DEPT: DENTISTRY

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: PUBLIC HEALTH RELEVANCE STATEMENT There is an urgent need to increase the number of scientists from diverse backgrounds who are committed to the study of oral biology and its relation to overall health. The MUSC RAISE program seeks to overcome barriers that have prevented or hindered undergraduate students from gaining experiences that would engage and inspire students to continue their professional careers in the field of oral biology. The ultimate goal of the RAISE program is to foster the development of a cadre of diverse scientists who will become part of the scientific workforce dedicated to improving oral health and overall health for all.

PI_NAMEs: WESTWATER, CAROLINE ;YILMAZ, OZLEM  (contact)

PROGRAM_OFFICER_NAME: MCGUIRL, MICHELE

PROJECT_TERMS: Admission activity;Advisory Committees;Area;Award;Awareness;Basic Science;Biology;Biomedical Research;Brothers;Cancer Education Grant Program;Cardiovascular Diseases;Cardiovascular Physiology;career;Clinical;college;craniofacial;Data;Data Pooling;Dedications;Development;disadvantaged background;Doctor of Philosophy;economic disparity;Education;Educational Curriculum;Enrollment;Environment;Ethnic Origin;Evaluation;experience;Faculty;faculty mentor;First Generation College Students;Fostering;Gender;Goals;Growth;hands on research;Health;health science research;higher education;improved;Individual;Institution;Interview;Investigation;Journals;Knowledge;Laboratories;Leadership;lectures;Life Experience;life span;Malignant Neoplasms;Medical;member;Mentors;minority student;National Heart, Lung, and Blood Institute;National Institute of Dental and Craniofacial Research;National Institute of Drug Abuse;Oral;oral biology;Oral health;Outcome;Participant;Patient Self-Report;peer;Personal Satisfaction;prevent;Productivity;programs;public health relevance;Race;Records;recruit;Reproducibility;Request for Applications;Research;Research Project Grants;Research Training;Resources;responsible research conduct;Science;Scientist;Series;Sex Orientation;Sister;skills;social;social disparities;Social support;Socioeconomic Status;South Carolina;Strategic Planning;Structure;student participation;Students;Substance Use Disorder;success;summer research;Surveys;symposium;Talents;Training;Training Programs;undergraduate research;undergraduate student;Underrepresented Minority;Underrepresented Populations;Underrepresented Students;United States National Institutes of Health;Universities

PROJECT_TITLE: Raise Awareness In Students Early (RAISE) in Oral Biology Program

STUDY_SECTION_NAME: Special Emphasis Panel[ZDE1 AC (05)]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Cannabidiol Research;Cannabinoid Research;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Methamphetamine;Natural Products;Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: Project Narrative Drug abuse and addiction is inextricably linked with HIV/AIDS pandemic. Among them, methamphetamine abuse has been associated with worse disease outcome and higher mortality rate among people infected with HIV. This study aims to investigate 1) the molecular mechanisms of methamphetamine on inflammation and immune dysfunction in people living with HIV and 2) the therapeutic potentials of autophagy inducers for treating hyperinflammation in HIV infection and methamphetamine abuse.

PI_NAMEs: FULCHER, JENNIFER ;ZHANG, YE ;ZHEN, ANJIE  (contact)

PROGRAM_OFFICER_NAME: BORGMANN, KATHLEEN RUTH

PROJECT_TERMS: Acceleration;Acquired Immunodeficiency Syndrome;Adverse effects;antiretroviral therapy;antiviral immunity;Autophagocytosis;Brain;Cannabidiol;Cannabinoids;Cannabis;Cell Physiology;Cells;Central Nervous System;Chronic;Clinical;cognitive function;comorbidity;Complex;Cytoplasm;Death Rate;Disease Outcome;Disease Progression;Drug abuse;Drug Addiction;Drug Combinations;Drug Interactions;Drug usage;Engraftment;exhaust;exhaustion;Frequencies;Functional disorder;Hematopoietic stem cells;HIV;HIV Infections;HIV/AIDS;Homeostasis;Human;humanized mouse;Immune;immune activation;Immune response;Immune system;Immune System Diseases;Immunity;Impairment;improved;in vivo;Individual;Inflammasome;Inflammation;Inflammatory;Interferons;Interleukin-1 beta;Investigation;Link;Lymphoid Tissue;Macrophage;marijuana use;Mediating;Methamphetamine;methamphetamine abuse;methamphetamine effect;methamphetamine use;methamphetamine user;Mitochondria;Modeling;Molecular;monocyte;mortality;mouse model;Mus;Neurocognitive Deficit;Neuroglia;neuroinflammation;novel;Organelles;pandemic disease;pathogen;Pathogenesis;Patients;Peripheral;peripheral blood;Peripheral Blood Mononuclear Cell;Persons;Pharmaceutical Preparations;polysubstance use;preclinical study;psychostimulant;Published Comment;Quality Control;reconstitution;Reporting;Research;response;Sampling;Signal Transduction;single-cell RNA sequencing;Sirolimus;Stimulant;stimulant use;Substance abuse problem;substance use;success;T cell response;T-Lymphocyte;targeted treatment;Tetrahydrocannabinol;Therapeutic;Therapeutic Intervention;TNF gene;transmission process;Transplantation;Viral;Viral Load result;viral rebound;Viral reservoir;Withdrawal

PROJECT_TITLE: Targeting autophagy to reduce inflammasome-mediated inflammation and immune dysfunction in HIV and methamphetamine use

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 JRB-N (O1)]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Dental, Oral, and Craniofacial Disease;Genetics;Human Genome;Nanotechnology;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_CITY: COLLEGE STATION

ORG_NAME: TEXAS ENGINEERING EXPERIMENT STATION

PHR: PROJECT NARRATIVE This proposal aims to design a new class of osteoinductive biomaterials for in situ bone regeneration in the absence of exogenous growth factor. The proposed approach will circumvent the current clinical limitations associated with the use of supraphysiological doses of growth factors. The completion of the proposed work will provide a new class of biomaterials for cranial bone reconstruction, and eventually advance bone regeneration approaches for humans.

PI_NAMEs: GAHARWAR, AKHILESH K. (contact);GREGORY, CARL A.

PROGRAM_OFFICER_NAME: VERBRIDGE, SCOTT SPENCER

PROJECT_TERMS: 3-Dimensional;3D Print;angiogenesis;Animal Model;Biocompatible Materials;Biodegradation;bioink;Biology;Biomedical Engineering;Blood Vessels;bone;Bone Formation Stimulation;bone reconstruction;Bone Regeneration;Bone Tissue;Bone Transplantation;Calvaria;Cell Therapy;Cells;Cephalic;ChIP-seq;chromatin remodeling;Clinical;clinical application;clinically relevant;Computational Biology;congenital anomaly;craniofacial bone;craniomaxillofacial;CRISPR/Cas technology;Data;Defect;Dentists;design;Dose;endogenous stem cells;Epigenetic Process;Esthetics;Excision;fabrication;Future;Gene Expression;Geometry;Goals;Growth Factor;Heterotopic Ossification;Human;Implant;In Situ;in vivo;Infection;inhibitor;Invaded;Mandible;Mechanics;Medical Device;Mesenchymal Stem Cells;Minerals;minimally invasive;Modeling;Molecular;Mus;nano;nanocomposite;nanomaterials;nanoparticle;Natural regeneration;next generation sequencing;Orthodontics;Osteogenesis;osteogenic;Osteolysis;Pathologist;Pathway interactions;Patients;placebo group;Porosity;programs;Publishing;Rattus;recombinant human bone morphogenetic protein-2;Regulatory Element;repaired;Reporting;Research;response;restoration;scaffold;Scientist;Shapes;Silicates;Site;stem cells;success;Swelling;Techniques;Technology;Testing;Therapeutic;Thinness;Tissue Engineering;tissue regeneration;Tissues;transcriptome sequencing;Trauma;two-dimensional;Vascularization;Work

PROJECT_TITLE: Osteoinductive Nanosilicate-Based Biomaterials for In Situ Craniomaxillofacial Bone Regeneration

STUDY_SECTION: MTE

STUDY_SECTION_NAME: Musculoskeletal Tissue Engineering Study Section[MTE]


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Digestive Diseases;Inflammatory Bowel Disease

ORG_CITY: SEATTLE

ORG_NAME: BENAROYA RESEARCH INST AT VIRGINIA MASON

PHR: PROJECT NARRATIVE The proposed research is relevant to the mission of the NIH because a better understanding of the mechanisms of drug action will contribute to more effective use of existing therapies and development of new ones. The proposed work is of particular relevance to intestinal disorders such as inflammatory bowel disease.

PI_NAMEs: LACY-HULBERT, ADAM ;LORD, JAMES DANIEL (contact)

PROGRAM_OFFICER_NAME: HUDSPETH, KELLY

PROJECT_TERMS: adalimumab;Address;Affect;Aminosalicylate;Animal Model;Anti-Inflammatory Agents;biobank;Biological Markers;Biological Products;Biopsy;Blood;Cells;Characteristics;Chronic;Clinic;Clinical;Clinical Trials;Colitis;Colon;Crohn's disease;Data;data modeling;Dendritic Cells;Development;disability;Disease;Disease remission;Dose;drug action;drug efficacy;Drug Monitoring;effective therapy;emerging adult;expiration;Exploratory/Developmental Grant;FDA approved;Frequencies;Funding;high reward;Human;Immune;Immune system;Immunology;improved;Infection;Inflammation;Inflammatory;Inflammatory Bowel Diseases;integrin alpha4beta7;Integrins;Intestinal Diseases;Intestines;Legal patent;Leukocytes;Mature Lymphocyte;Mediating;migration;Mission;Modeling;Mucous Membrane;Nature;new therapeutic target;Pathogenesis;Patients;Pharmaceutical Preparations;Phenotype;Population;Population Heterogeneity;Positioning Attribute;predictive marker;predictive tools;prospective;Public Health;recruit;Recycling;Refractory;Remission Induction;Reporting;Research;response;response biomarker;Role;Safety;Sampling;Serum;Surface;T-Lymphocyte;Testing;Therapeutic;therapeutic target;TNF gene;tool;trafficking;Translational Research;Treatment Efficacy;Ulcerative Colitis;United States National Institutes of Health;Work;Youth

PROJECT_TITLE: DCs as clinical targets of anti-integrin therapy in IBD

STUDY_SECTION: DHMI

STUDY_SECTION_NAME: Digestive System Host Defense, Microbial Interactions and Immune and Inflammatory Disease Study Section[DHMI]


NIH_SPENDING_CATS: Bioengineering;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Diabetes;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Nutrition;Obesity;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: BLOOMINGTON

ORG_NAME: TRUSTEES OF INDIANA UNIVERSITY

ORG_STATE: IN

PHR: PROJECT NARRATIVE Type 2 diabetes disproportionately affects the health and wellbeing of rural Hispanics in the US; however, access to evidence-based diabetes preventive services is limited for this population. Using implementation research and community-engaged methods, we will design and pilot-test a health unit model that provides diabetes risk screening, counseling, and referrals to Hispanics living in rural Indiana. This project represents a new iteration of outreach strategies to better serve rural Hispanic populations.

PI_NAMEs: GALAVIZ, KARLA IVETTE;GONZALEZ CASANOVA, INES  (contact)

PROGRAM_OFFICER_NAME: SERRANO, KATRINA JANE

PROJECT_TERMS: access disparities;Address;Adult;Affect;aged;Agreement;American;bilingualism;Blood capillaries;Blood Glucose;Body mass index;Breathing;Chronic Disease;Clinic;Clinical;Collaborations;Communities;community engaged approach;community engagement;Community Health Aides;Community Participation;community partners;community setting;cost;Counseling;County;Data;design;Diabetes Mellitus;Diabetes prevention;diabetes risk;Disparity;effectiveness testing;Epidemic;evidence base;evidence based guidelines;Exploration, Preparation, Implementation, and Sustainment;Face;Feedback;Glycosylated hemoglobin A;Goals;Guidelines;Health;health care availability;Health Care Costs;high risk population;Hispanic;Hispanic Populations;human centered design;Hybrids;Immersion;implementation research;Indiana;Individual;Intervention;Interview;iterative design;Language;Letters;Link;Low income;Measurement;Methods;minority communities;Minority Groups;minority health;Mission;Mobile Health Units;Modeling;Motor Vehicles;National Institute of Diabetes and Digestive and Kidney Diseases;Non-Insulin-Dependent Diabetes Mellitus;Not Hispanic or Latino;novel;Obesity;outreach;Overweight;Participant;Personal Satisfaction;pilot test;Population;preference;Preparation;Prevalence;Preventive;preventive intervention;Preventive screening;Preventive service;Process;prototype;Questionnaires;Recommendation;recruit;Research;Research Priority;Resources;Risk;Risk Reduction;Rural;rural counties;Rural Health;rural Hispanic;rural setting;Sampling;screening;Screening Result;Services;socioeconomics;Spanish/English;Strategic Planning;Structure;success;Tablets;Testing;tool;Training;Uninsured;United States Preventative Services Task Force;Universities;Visit;Vulnerable Populations;Work

PROJECT_TITLE: Mobile pop-up units for diabetes prevention among Hispanics in rural Indiana

STUDY_SECTION: HPC

STUDY_SECTION_NAME: Health Promotion in Communities Study Section[HPC]


NIH_SPENDING_CATS: Biotechnology;Drug Abuse (NIDA only);Genetics;HIV/AIDS;Infectious Diseases;Substance Misuse

ORG_CITY: MIAMI

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: FLORIDA INTERNATIONAL UNIVERSITY

ORG_STATE: FL

PHR: PROJECT NARRATIVE: Non-AIDS comorbidities are a significant cause of mortality in people living with HIV in the cART eRA due to the inability to erradicate HIV reservoirs in diverse anatomical sites. Gene therapy approaches directly targeting HIV are largely ineffectual due to escape mutants and a lack of an in vivo delivery mechanisms for transgenes. Combining broad spectrum in vivo delivery of CRISPR-based approaches with selective and self-limiting expression only in HIV-infected cells can overcome these limitations.

PI_NAMEs: UNWALLA, HOSHANG JEHANGIR (contact)

PROGRAM_OFFICER_NAME: POON, BETTY

PROJECT_TERMS: Abbreviations;adaptive immune response;Aging;Anatomy;Animal Model;Anti-Retroviral Agents;antiretroviral therapy;Automobile Driving;Binding;Biological Assay;Biological Availability;Bone Marrow;Bone Marrow Stem Cell;C-terminal;Cell model;Cell Survival;Cells;cellular targeting;Chronic;Clustered Regularly Interspaced Short Palindromic Repeats;cofactor;comorbidity;CRISPR/Cas technology;cyclin T1;Cyclins;Data;Disabling;Disease;Disease remission;DNA;DNA cassette;DNA Polymerase II;Drug Kinetics;Drug or chemical Tissue Distribution;efficacy evaluation;Escape Mutant;Etiology;Excision;exhaustion;Gene Delivery;gene therapy;Generations;Genes;genetic payload;Genetic Transcription;Genome;Goals;Guide RNA;Hematopoietic stem cells;HIV;HIV Envelope Protein gp120;HIV Infections;HIV/AIDS;Human Genome;immune activation;improved;in vivo;Infection;knock-down;Legal patent;Lentivirus Vector;Life;Lung;Mediating;Modeling;Morbidity - disease rate;mortality;mouse model;Mus;Mutation;Patients;Peptide Signal Sequences;peripheral blood;Peripheral Blood Mononuclear Cell;Persons;Pharmacodynamics;Phosphorylation;Plasmids;Play;Polyadenylation;Population;Positive Transcriptional Elongation Factor B;prevent;Primary Cell Cultures;Proliferating;promoter;Proviruses;recruit;Regimen;Regulation;Reporting;Role;Safety;Site;System;T memory cell;T-Lymphocyte;Testing;Therapeutic;therapeutic gene;therapeutic target;Toxic effect;Transcription Elongation;Transgenes;Viral;Viral Proteins;Viral reservoir;Virus;Virus Latency

PROJECT_TITLE: A CRISP(e)R way to silence HIV

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 BJM-A (S1)]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Patient Safety;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: OMAHA

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: Project Narrative Although alcohol use disorder affects 9% of the US population, less than one in ten affected individuals receives any treatment. Despite being present in up to 18% of surgical patients and being a modifiable risk factor, alcohol use disorder-specific interventions are rarely provided by perioperative clinicians. The Leveraging Alcohol Use Disorder Screening for Treatment in Routine Perioperative Care: AllUsCare proposal will extend alcohol use disorder screening into perioperative interventions and lay the groundwork to test optimized alcohol use disorder intervention bundles most likely to be acceptable, feasible, and effective in a future pragmatic multi-center clinical trial.

PI_NAMEs: BARTELS, KARSTEN  (contact);FERNANDEZ, ANNE CHRISTIE;SESSLER, DANIEL I

PROGRAM_OFFICER_NAME: KWAKO, LAURA ELIZABETH

PROJECT_TERMS: 12 year old;acceptability and feasibility;Affect;aged;alcohol abuse therapy;Alcohol consumption;alcohol intervention;alcohol misuse;alcohol seeking behavior;alcohol use disorder;alcohol use initiation;Attention;Back;barrier to care;Behavior Therapy;behavioral health;binge drinking;Caring;Cessation of life;Characteristics;Clinical;Clinical Trials Design;cluster trial;Coronary Arteriosclerosis;cost;Data;Data Collection;design;disability-adjusted life years;drinking;DSM-V;economic impact;forging;Future;Grant;Guidelines;Health;health care availability;health care settings;health disparity;health disparity populations;health equity;Health Services;Healthcare;Heavy Drinking;high risk;Hospitalization;Individual;inner city;Institution;Institutional Review Boards;Intervention;Measures;Medical;Medicare;Mental Health;Methods;modifiable risk;multi-component intervention;Multi-Institutional Clinical Trial;multiphase optimization strategy;National Institute of Drug Abuse;National Institute on Alcohol Abuse and Alcoholism;novel;Nursing Staff;observational cohort study;Operative Surgical Procedures;Outcome;Outcome Assessment;Outcome Measure;patient engagement;Patients;Perioperative;Perioperative Care;pharmacologic;Population;pragmatic trial;Process;prospective;Provider;Psychiatrist;Psychologist;Qualitative Research;Randomized;Research;Research Priority;Resources;Risk;Risk Factors;Rural Population;Sampling;screening;Screening procedure;secondary outcome;service intervention;social stigma;Substance Use Disorder;surgical risk;Testing;timeline;United States National Institutes of Health

STUDY_SECTION: AA

STUDY_SECTION_NAME: Clinical, Treatment and Health Services Research Study Section[AA-3]


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Dietary Supplements;Nutrition

PHR: PROJECT NARRATIVE: Our risk of radiation exposure, whether terrestrial or during space flight, continues to increase creating an urgent need to identify radioprophylactics to combat irradiation injury. Remarkably radioresistant naturally occurring fungi offer a unique and powerful system to identify irradiation countermeasures. Our proposal will test dietary supplementation with radioresistant fungi using Drosophila to identify radioprophylactics.

PI_NAMEs: COX, RACHEL TAFEL (contact)

PROGRAM_OFFICER_NAME: ZOU, SIGE

PROJECT_TERMS: Acute;Age;arm;Astronauts;Beta Particle;Biological Models;Body System;Bone Marrow;Cell division;cell injury;Cells;Cellular biology;Chernobyl Nuclear Accident;combat;Consumption;dietary;Dietary Administration;Dietary Supplementation;dietary supplements;DNA Damage;Dose;Drosophila genus;Effectiveness;emergency service responder;Environment;Exposure to;feeding;fly;Food Supplementation;fungus;Future;gamma irradiation;Gastrointestinal tract structure;Genetic;Genotype;Growth;Hematopoietic;Human;improved;in vivo;interest;International;Intervention;Ionizing radiation;irradiation;Knowledge;life span;Longevity;Medicine;Methods;Mitotic;Modeling;Molecular;mutant;novel;Nuclear;Nuclear Power Plants;Ovary;oxidative damage;Parkin;Paste substance;Patients;Pharmacologic Substance;Predisposition;Proliferating;prophylactic;Proteins;Radiation;radiation effect;Radiation exposure;Radiation induced damage;Radiation Injuries;Radiation Protection;radiation resistance;radiation risk;Radiation therapy;Radiobiology;Radiology Specialty;radioprotected;radioresistant;repaired;reproductive organ;Research;Resistance;screening;Screening procedure;Source;Space Flight;space station;Syndrome;System;terminally differentiated effector memory (TEM) T cells;Testing;Therapeutic;Time;Toxic effect;Transplantation;Vertebrates

PROJECT_TITLE: Identifying the radioprotective potential of radiation-resistant fungi using Drosophila


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Breast Cancer;Cancer;Cancer Genomics;Genetics;Human Genome;Physical Injury - Accidents and Adverse Effects;Radiation Oncology;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human;Women's Health Research

ORG_CITY: NEW HAVEN

ORG_DEPT: ORTHOPEDICS

ORG_NAME: YALE UNIVERSITY

PHR: Project Narrative: Pathological fracture calluses are deficient and very often fail to ossify despite anti-cancer drug therapy, radiation therapy and anti-resorptive agents including Rank:Fc antibody (denosumab) or bisphosphonates (zoledronate). There is no mechanistic understanding as to why fractures do not heal well in the presence of certain types of breast cancer cells. We expect to establish a novel mechanism-based therapeutic paradigm for devastating patients suffering from pathological fractures secondary to breast cancers, the most common cancer in women and causing fractures.

PI_NAMEs: LEE, FRANCIS YOUNG-IN (contact)

PROGRAM_OFFICER_NAME: NICKS, KRISTY

PROJECT_TERMS: 3-Dimensional;4T1;Address;Adjuvant Therapy;Affect;Animal Model;Antibodies;Antineoplastic Agents;Architecture;Biology;biomechanical test;Biomechanics;bisphosphonate;Blinded;bone;Bone callus;bone fracture repair;Bone Marrow;Bone Resorption;Breast;Breast Cancer Cell;cancer cell;Cancer Patient;Cell Lineage;cell type;Cells;clinical care;Coculture Techniques;Complex;cortical bone;Critiques;cytokine;Data;Differentiated Gene;Diffusion;Disseminated Malignant Neoplasm;Dominant-Negative Mutation;experimental study;Femoral Fractures;Femur;Fracture;Future;Gene Expression;Genetic Suppression;Growth;Hematoma;Histology;Immunohistochemistry;Impairment;improved;in vivo;Inflammation;Inflammatory;inflammatory breast cancer;inhibitor;Interleukins;kinase inhibitor;Knowledge;Malignant Breast Neoplasm;Malignant Neoplasms;MAP2K1 gene;MAPK3 gene;Metastatic breast cancer;microCT;Molecular Target;Mus;new therapeutic target;novel;novel therapeutics;Osteoblasts;osteochondral tissue;Osteoclasts;Osteocytes;Osteogenesis;osteogenic;osteoprogenitor cell;Pathological fracture;Patients;Periosteal Cell;Pharmacotherapy;Phosphorylation;Phosphotransferases;Physiologic Ossification;pre-clinical;progenitor;Proteins;Radiation therapy;RNA;Sampling;Scientist;Secondary to;Signal Transduction;Site;Stains;Suggestion;Testing;Therapeutic;Therapeutic Trials;Time;TNF gene;transcriptome;transcriptomics;Transfection;translational therapeutics;treatment group;Western Blotting;Woman;Zoledronate

PROJECT_TITLE: Rescuing impaired fracture healing by molecular targeting

STUDY_SECTION: SBSR

STUDY_SECTION_NAME: Skeletal Biology Structure and Regeneration Study Section[SBSR]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Behavioral and Social Science;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Dementia;Neurosciences;Prevention

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative The Summer Undergraduate Research Experience in Aging and Neurologic Diseases at Washington University recruits undergraduate students with diverse backgrounds and disciplinary interests for an eight-week introduction to research on the prevention and treatment of neurologic disorders in older adults. Students join a laboratory focused on one of three neurological conditions (stroke, Parkinson’s disease, or dementia) for a closely mentored research experience. They also gather together for lectures, discussions, field trips, and professional development seminars to nurture their knowledge, skills, professional identity, and momentum as scholars.

PI_NAMEs: CARPENTER, BRIAN D (contact)

PROGRAM_OFFICER_NAME: MATTHEWS, MARGUERITE

PROJECT_TERMS: Address;Age;Aging;aging population;aging process;Attitude;Behavioral;Behavioral Research;Biomedical Research;built environment;Caring;Characteristics;Clinical;Clinical Research;cohort;Communities;Country;Dementia;Development;Discipline;Educational process of instructing;Elements;experience;Faculty;Family;field trip;Fostering;Future;Goals;Growth;hands on research;Healthcare Systems;Home;human old age (65+);Individual;Institution;interdisciplinary approach;interest;Intervention;Investigation;Knowledge;Laboratories;laboratory experience;Laboratory Research;late life;Learning;lectures;Life;member;Mentors;Modification;multidisciplinary;Nervous System Disorder;Neurologic;older adult;Parkinson Disease;Patients;Persons;Population;posters;Preparation;Prevention;Process;programs;Public Health;recruit;Research;Research Personnel;Research Training;Resources;Scholarship;Science;Scientist;skills;social;Societies;Stroke;Structure;Students;summer program;summer research;Training;trend;undergraduate research experience;undergraduate student;United Nations;United States;Universities;Washington;Work

PROJECT_TITLE: Enhancing Undergraduate Preparation for Research in Aging and Neurologic Diseases

STUDY_SECTION_NAME: Special Emphasis Panel[ZNS1 SRB-D (27)]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Child Abuse and Neglect Research;Childhood Injury;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Social Determinants of Health;Violence Against Women;Violence Research;Women's Health Research;Youth Violence

ORG_CITY: CHAPEL HILL

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: Project Narrative Relevance to Public Health The goals of this study are to examine pathways that maternal childhood abuse may impact the development of her offspring from infancy to adolescence. Identifying risk and resilience factors in offspring of abuse survivors will provide critical evidence for developing interventions that may mitigate adverse outcomes across two generations.

PI_NAMEs: ZVARA, BHARATHI J. (contact)

PROGRAM_OFFICER_NAME: GILBERT, LEAH KAYE

PROJECT_TERMS: Address;Adolescence;Adolescent;Adult;adverse outcome;Age;Age Months;Aggressive behavior;Alcohol abuse;Anxiety;Area;Behavior;Behavioral;Biological;biopsychosocial;boys;caregiving;Child;Child Abuse;Child Abuse and Neglect;Child Development;Child Rearing;childhood adversity;Cognitive;Complex;conduct problem;cost effective;Data Analyses;deprivation;Development;Dimensions;early childhood;early life adversity;emotional adjustment;Environment;Equation;experience;externalizing behavior;Family;Family Study;Fright;Funding;Future;Generations;girls;Goals;Health;health goals;Heterogeneity;High Prevalence;Home;Hydrocortisone;infancy;innovation;interest;intergenerational;Interruption;Intervention;intimate partner violence;Knowledge;Learning;Life;Life Cycle Stages;Link;Longitudinal cohort;longitudinal dataset;Low income;Maps;Measures;Mediating;Mediator;Mental Depression;Mental Health;Methods;Modeling;Mothers;Motion;neglect;Neurocognitive;neurodevelopment;Neurosciences;novel;offspring;Outcome;parental role;Pathway interactions;Patient Self-Report;Pattern;pediatric trauma;Physiological;Physiology;Process;Psychopathology;Public Health;Race;Recording of previous events;recruit;Reporting;Research;resilience factor;response;Risk;Risk Factors;Role;Rural;Salivary;Sampling;sex;Specific qualifier value;Stress;Subgroup;Substance abuse problem;Survivors;Symptoms;System;Testing;therapy development;Time;Trauma;United States;United States National Institutes of Health;Woman

PROJECT_TITLE: Exploring Mechanisms Linking Maternal Childhood Adversity to Adolescent Psychopathology: The Role of Early Childhood Deprivation and Threat

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cannabinoid Research;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Endocannabinoid System Research;Natural Products;Neurosciences;Substance Misuse

ORG_DEPT: PSYCHIATRY

PHR: PROJECT NARRATIVE Cannabis use is rapidly growing in older adults, but there is no reliable experimental data about the acute effects of cannabinoids in healthy older adults. In this double-blind, placebo-controlled study, the impact of age on THC effects will be investigated.

PI_NAMEs: D'SOUZA, DEEPAK CYRIL (contact);MARTIN, ASHLEY SCHNAKENBERG

PROGRAM_OFFICER_NAME: FEDOTA, JOHN RAPHAEL

PROJECT_TERMS: 21 year old;Acceleration;Acute;Adult;Age;age difference;age effect;age group;age related;age related changes;Aging;aging brain;aging population;anxious;Attention;Auditory;baby boomer;Behavioral;Benefits and Risks;Binding;Blood;Blood Pressure;Cannabinoids;Cannabis;cardiovascular effects;cardiovascular risk factor;Cardiovascular system;CB1 knockout;Chronic;CNR1 gene;Cognition;Cognitive;cognitive function;cognitive reserve;Data;density;design;Dopamine;Double-Blind Method;Education;Electroencephalography;Electrophysiology (science);endogenous cannabinoid system;EP300 gene;Foundations;Generations;Global Change;Goals;Heart Rate;Hybrids;imaging study;Impaired cognition;indexing;Individual;information processing;Intravenous;Knockout Mice;Laboratory Study;Legal;Legal Status;Life;life span;Literature;marijuana legalization;marijuana use;Measures;Medical Marijuana;Memory;Memory impairment;Menstrual cycle;Messenger RNA;Meta-Analysis;Metabolism;Methods;Modeling;Mus;neural;Neurotransmitters;Noise;older adult;Older Population;Opioid;Persons;Physiological;Placebo Control;placebo controlled study;Placebos;Population;Positron-Emission Tomography;Predisposition;Psychomotor Performance;Public Health;Randomized;Recreation;recruit;Reporting;Research;response;Rest;Rewards;Risk;risk perception;Solid;statistics;System;Testing;Time;treatment guidelines;young adult

PROJECT_TITLE: Acute effects of THC in older adults

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Mental Health;Palliative Care;Pediatric;Social Determinants of Health

ORG_CITY: CORAL GABLES

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE While the emotional toll of bereavement is well-recognized, resulting disruptions to social connection often go unnoticed and unaddressed, leaving millions of Americans at risk for the well-established harms of social isolation. The proposed study will identify intervention targets and adaptive strategies for mitigating social isolation and for retaining, repairing, and rebuilding social connections following what is widely acknowledged as the most devastating form of loss: the death of a child. Applying the public health model of bereavement care tailored to individuals’ support needs, the long-term goal of this research is to provide healthcare systems with empirically-based resources that can be used for bereavement support and community education.

PI_NAMEs: LICHTENTHAL, WENDY G. (contact)

PROGRAM_OFFICER_NAME: JENKINS, TAMMARA L

PROJECT_TERMS: Address;adverse outcome;American;Bereavement;Bereavement Care;Cardiovascular Diseases;Cessation of life;Characteristics;Child;Cigarette;clinical care;Communities;Community Health Education;Data;Dementia;demographics;Deterioration;Emergency Situation;Emotional;Evaluation;experience;Face;Family;Feeling;Friends;Future;Goals;Grief reaction;Health;health care settings;Healthcare Systems;Individual;informal support;Intervention;intervention delivery;Interview;Loneliness;Mediating;Mental disorders;Methods;Modeling;mortality;mortality risk;multi-component intervention;Outcome;Pain;palliative;Parents;Population;Positioning Attribute;preference;Prevalence;protective factors;Public Health;repaired;Research;Resources;Risk;Risk Factors;Rupture;Smoking;social;social integration;Social isolation;Social Network;social relationships;Social support;Structure;Surveys;therapy development;Time

PROJECT_TITLE: Impact of Parental Bereavement on Social Connection, Isolation, and Health

STUDY_SECTION: SPIP

STUDY_SECTION_NAME: Social Psychology, Personality and Interpersonal Processes Study Section[SPIP]


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Umbilical Cord Blood/ Placenta;Stem Cell Research - Umbilical Cord Blood/ Placenta - Human;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: PROJECT NARRATIVE Human Immunodeficiency Virus (HIV-1) causes a chronic, incurable infection, and while existing therapies can suppress the virus, people with HIV develop more comorbid conditions than uninfected individuals. This proposal aims to investigate the impact of nicotine on NLRP3 inflammasome activation in people with HIV and substance use disorders by infecting human tonsil explants and iPSC-derived microglia with HIV-1, and characterizing how nicotine impacts HIV latency and the activation of inflammasomes in CNS cells, and using scRNAseq on post- mortem brains. The study team has extensive expertise in HIV virology, inflammasome biology, and substance use disorder, and successful completion of the proposed studies will inform future therapeutic targeting of the NLRP3 inflammasome in mitigating the inflammatory sequelae associated with HIV and nicotine use.

PI_NAMEs: AKBARIAN, SCHAHRAM ;CHEN, BENJAMIN K;SWARTZ, TALIA H (contact)

PROGRAM_OFFICER_NAME: TSAI, SHANG-YI ANNE

PROJECT_TERMS: Acute;Address;Affect;AIDS dementia;Autopsy;Biological Markers;Biology;Brain;Brain region;Cell Communication;cell type;Cells;Central Nervous System;Chronic;Cigarette Smoker;clinically relevant;cohort;Collaborations;comorbidity;Data;Development;differential expression;direct application;Disease;Encephalitis;experience;Future;Genes;Goals;HIV;HIV Infections;HIV-1;HIV-2;HIV-associated neurocognitive disorder;Human;humanized mouse;Immune;Immune response;Impaired cognition;Individual;induced pluripotent stem cell;Infection;Inflammasome;Inflammation;Inflammatory;Inflammatory Response;innovation;insight;Literature;Lymphoid Tissue;Microglia;Modeling;Morbidity - disease rate;mouse model;multidisciplinary;Myeloid Cells;National Institute of Drug Abuse;Neurocognitive;Neurocognitive Deficit;neuroinflammation;Neurologic Symptoms;new technology;Nicotine;nicotine exposure;nicotine use;Nicotinic Receptors;non-smoker;novel;Outcome;Pathway interactions;Persons;Play;Population;Productivity;Research;Role;Sampling;Signal Pathway;single-cell RNA sequencing;Site;Smoke;Smoker;Smoking;Substance Use Disorder;System;targeted treatment;Testing;therapeutic development;Therapeutic Intervention;therapeutic target;Time;Tissue Model;Tobacco smoke;Tobacco smoking behavior;Tonsil;transcriptome sequencing;transcriptomics;United States;Up-Regulation;Viral reservoir;virology;Virus;Virus Replication;Work;Xenograft procedure

PROJECT_TITLE: Nicotine and NLRP3 Inflammasome in HIV-1-Associated CNS Inflammation


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cocaine;Drug Abuse (NIDA only);Genetics;Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: WINSTON-SALEM

ORG_DEPT: NEUROSCIENCES

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative Chronic cocaine exposure produces behavioral and neurobiological alterations that are associated with vulnerability to cocaine-seeking and taking behavior. This project will investigate a novel molecular mechanism that underlies changes in dopamine D3 receptor function in the brain. Completion of the project may provide new molecular targets for potential therapeutic intervention.

PI_NAMEs: CHEN, RONG  (contact)

PROGRAM_OFFICER_NAME: ANANTHAN, SUBRAMANIAM

PROJECT_TERMS: adeno-associated viral vector;Animal Model;Animal Testing;Animals;Behavior;Behavioral;Binding;Brain;Brain region;cell type;Chronic;Cocaine;cocaine exposure;cocaine seeking;cocaine self-administration;Cocaine use disorder;Cultured Cells;Data;Dopamine;dopamine D3 receptor;drug reward;Event;extracellular;Female;Genes;Genetic;Goals;Human;in vivo;Intake;Link;male;Microdialysis;Molecular;Molecular Target;Mus;Neurobiology;neuroblastoma cell;Neurons;novel;Nucleus Accumbens;overexpression;Pattern;Pharmacotherapy;Phase;preservation;Rattus;receptor;receptor function;Regulation;Reporting;response;RNA Splicing;Rodent;Role;sex;Substance Use Disorder;System;Testing;Therapeutic Intervention;tool;Transcript;translational potential;transmission process;Variant;Ventral Tegmental Area

PROJECT_TITLE: Drd3 transcript variants and cocaine self-administration

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 IXR-N (O1)]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Pediatric;Pregnancy;Rare Diseases;Vector-Borne Diseases;Zika Virus

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE This proposal will provide the first comprehensive analysis of the early events in fetal innate and adaptive immune programming to viral infection and inflammation across gestation and how immune signaling influences cellular stress-response in the fetal brain. Creation of a fetal immune atlas in response to viral infection and inflammation will provide a critical foundation for understanding how immune signaling can be targeted by novel therapeutics for fetal neuroprotection.

PI_NAMEs: ADAMS WALDORF, KRISTINA M. (contact)

PROGRAM_OFFICER_NAME: GAUTAM, RAJEEV

PROJECT_TERMS: Acute;adaptive immune response;adaptive immunity;Address;Adult;Animals;Atlases;Autophagocytosis;Autopsy;Bioinformatics;biological adaptation to stress;Biological Assay;Blood;Brain;Brazil;CCL4 gene;cell injury;Cells;Cellular Stress;Collection;cytokine;cytotoxicity;Data;Data Set;Enzyme-Linked Immunosorbent Assay;Event;experimental study;Female;fetal;fetal blood;fetal brain injury;Fetal Development;fetal inflammatory response syndrome;Fetal Tissues;fetus cell;First Pregnancy Trimester;Flow Cytometry;Foundations;Frequencies;functional genomics;Gene Expression;gene network;Gestational Age;Growth;Hour;Human;human fetus tissue;Immune;immune activation;Immune Response Genes;Immune signaling;Immunohistochemistry;Immunologics;Immunology;immunoregulation;in vivo;Infection;Inflammation;Inflammatory;Inflammatory Response;Injury;innate immune pathways;Innate Immune Response;innovation;Interferons;Interleukin-6;IRF3 gene;Knowledge;Link;Liquid substance;lymphoid organ;male;Measures;Metabolic;Modeling;multidimensional data;nano-string;Natural Immunity;neuroprotection;new therapeutic target;nonhuman primate;novel therapeutics;Organ;organ injury;Pathogenesis;Pathway interactions;Placenta;Predisposition;Pregnancy;pregnant;Premature Birth;prenatal therapy;Production;programs;Regulation;response;response to injury;Sendai virus;Signal Pathway;single-cell RNA sequencing;Spleen;Stains;Stimulus;subcutaneous;System;Therapeutic;Third Pregnancy Trimester;Thymus Gland;Tissues;TNF gene;tool;Umbilical Cord Blood;Viral;Virus;Virus Diseases;Virus Replication;Western Blotting;Whole Blood;Zika Virus;ZIKV infection

PROJECT_TITLE: Impact of Zika Virus Infection on Fetal Innate and Adaptive Immunity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 EMS-E (90)]