ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_NAME: MINNEAPOLIS VA  MEDICAL CENTER

PHR: Osteoarthritis is the most common cause of disability in the United States. It is even more common in Veterans than the general population, is the primary source of disability in combat-wounded veterans, and is the most common reason for a service member to be removed from active duty. Developing treatments that delay or reverse the joint damage of osteoarthritis has been difficult partly because the disease is not evident on x-rays until it is far advanced and likely not reversible. Microphones can be used to measure noise created by a damaged joint and are able to identify a healthy knee from one with disease. The goal of our project is to build a portable knee brace with an attached microphone that will measure noise from the knee in common clinical settings. This allow prompt identification of Veterans with early osteoarthritis and allow for therapies that prolong joint lifespan.

PI_NAMEs: EWART, DAVID T (contact)

PROJECT_TERMS: Accelerometer;Acoustics;active duty;advanced disease;Aging;Algorithms;Animal Model;Arthritis;Award;Biomechanics;career;Characteristics;Clinic Visits;Clinical;clinical encounter;clinical investigation;Collaborations;combat wound;Complex;Computers;Consumption;cost;cost effective;Custom;Data;Data Storage and Retrieval;Degenerative polyarthritis;design;Development;Device Designs;Devices;Diagnosis;disability;Disabling;disabling disease;Disease;Disease Progression;Doctor of Philosophy;Early Diagnosis;Early identification;early screening;electronic sensor;Engineering;Evaluation;Exercise;experience;Funding;Future;General Population;Goals;Head;Health;high risk;Image;Immunology;Incidence;individualized medicine;innovative technologies;inter-institutional;interest;Intervention;Investigation;iterative design;joint injury;Joints;K-Series Research Career Programs;Knee;Knee Osteoarthritis;knee replacement arthroplasty;Lesion;life span;Longevity;Magnetic Resonance Imaging;Measurement;Measures;Medical center;Medical Device;Memory;Mentors;Mentorship;Methods;microphone;mid-career faculty;miniaturized device;Minnesota;Modernization;Movement;Noise;non-invasive monitor;novel;Office Visits;Operative Surgical Procedures;Opiate Addiction;Orthotic Devices;Outcome Measure;palliative;Pathologic;Patients;Pharmaceutical Preparations;pharmacologic;Pharmacological Treatment;Pilot Projects;point of care;Population;Populations at Risk;portability;Prevalence;Process;professor;programs;Prosthesis;prototype;Provider;Publications;radiological imaging;Recording of previous events;Regenerative capacity;rehabilitation research;Rehabilitation therapy;Research;Research Personnel;rheumatologist;Risk;Roentgen Rays;Role;sensor;service member;side effect;Signal Transduction;Source;Standardization;symptom treatment;symptomatic improvement;Symptoms;System;Technology;Testing;Time;Translational Research;United States;United States Department of Veterans Affairs;Universities;Veterans;Walking;wearable device;wireless;wireless electronic;Work

PROJECT_TITLE: Development of an Orthosis with an Integrated Microphone for Measurement of Knee Acoustic Emissions in Pre-Radiographic Osteoarthritis

STUDY_SECTION: RRDS

STUDY_SECTION_NAME: Rehabilitation Research and Development SPiRE Program[RRDS]


ADMINISTERING_IC: CA

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Immunotherapy

ORG_CITY: BOSTON

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: Administrative CORE A- Narrative Core A is mandated for all P01s and is an essential element of the application which ensures maximal integration and utilization of diverse skills and resources to develop new treatments for cancers that are a burden to society in different ways yet allowing synergistic skills to come regardless of the geographic location of individuals. The limited budget available (<$100K) make it incumbent for the core to leverage essential services that are not directly funded by the P01 and offered by the Massachusetts General Hospital (MGH) or Harvard Medical School (HMS) but are crucial to the success of the Program. Although the Core was noted for being highly integrated, it continues to focus on enhancing this along with a succession plan for future planning, so that at the end, we have a more economical approach to healthcare.

PI_NAMEs: HASAN, TAYYABA  (contact)

PROJECT_TERMS: Academia;academic program;Address;Administrative Coordination;anti-cancer research;aspirate;Attention;Awareness;Budgets;cancer therapy;career development;checkpoint inhibition;Clinic;Clinical;clinical translation;Collaborations;Combined Modality Therapy;commercialization;Communication;Communities;Consultations;Critiques;Data;data sharing;Development;Education;Elements;Ensure;Equipment and supply inventories;equity, diversity, and inclusion;experience;experimental study;Fertilization;follow-up;Funding;Future;General Hospitals;Geographic Locations;global health;Goals;Grant;Healthcare;Human Resources;Image;image guided;Immune;Immune checkpoint inhibitor;Immune response;Immunology;Individual;Industry;industry involvement;innovation;insight;Institution;Intellectual Property;interest;International;Joints;knowledge base;Laboratories;Leadership;lectures;Logistics;Maintenance;Malignant neoplasm of pancreas;Malignant Neoplasms;Massachusetts;Medical;medical schools;meetings;member;Mentors;Molecular;next generation;Persons;Physicians;Physics;Play;Positioning Attribute;Postdoctoral Fellow;Pre-Clinical Model;Preparation;Principal Investigator;Process;Program Development;programs;public-private partnership;Publications;Published Comment;PUVA Photochemotherapy;Quality Control;Reporting;Research;Research Project Grants;Resources;response;Role;Schedule;Science;Scientist;Series;Services;Site;skills;Societies;Students;success;Techniques;Technology;Technology Transfer;Teleconferences;Therapeutic;timeline;Training;Training Programs;Translations;tumor;United States National Institutes of Health;Visit;web site;Work

PROJECT_TITLE: Core A: Administration, Integration, Education and Career Development


ADMINISTERING_IC: GM

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research

ORG_CITY: PROVIDENCE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PI_NAMEs: KOGUT, STEPHEN J (contact)

PROJECT_TERMS: Achievement;Address;Advisory Committees;Annual Reports;Award;Back;Caliber;Clinical Research;Clinical Sciences;Collaborations;Communities;community engagement;Community Health;Community Outreach;Community Participation;Competence;concept mapping;cost;Data;Data Element;data management;Data Management Resources;Databases;Decision Making;design;Development;Distal;Effectiveness;Environment;Evaluation;Feedback;feeding;Focus Groups;Fostering;Funding;Goals;Grant;Health;health equity;health practice;Health Priorities;Health Status;improved;innovation;Institution;Interview;Leadership;Location;Logic;Management Information Systems;Measurement;Measures;Mentors;Methodology;Methods;Mission;Modeling;Needs Assessment;operation;Outcome;Output;peer;Performance;Phase;Process;Program Effectiveness;Program Efficiency;Program Evaluation;programs;Protocols documentation;Publications;Quality of life;Reporting;Research;Research Design;Research Methodology;Research Personnel;Resource Sharing;Resources;Rhode Island;Role;satisfaction;Scientist;Series;service utilization;Services;Site;Statistical Data Interpretation;Structure;Surveys;Training;translational impact;Translational Research;translational research program;trend;Work

PROJECT_TITLE: Tracking and Evaluation Core


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cerebrovascular;Dementia;Endocrine Disruptors;Estrogen;Neurodegenerative;Neurosciences;Prevention;Social Determinants of Health

ORG_CITY: LEXINGTON

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: The proposed research is relevant to public health because it is expected to identify bisphenols as environmental risk factors for blood-brain barrier dysfunction and provide a mechanistic link between bisphenols, barrier dysfunction, and cognition in Alzheimer’s disease. Thus, the proposed research is relevant to the missions of the NINDS, the NIA, and the NIEHS that pertain to developing fundamental knowledge of environmental impacts on human health that will help promote healthier lives and reduce the burden of diseases and conditions related to aging.

PI_NAMEs: HARTZ, ANIKA M.S. (contact)

PROGRAM_OFFICER_NAME: YIN, XILING

PROJECT_TERMS: ABCB1 gene;Abeta clearance;Address;Aging;Air;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease risk;Amyloid beta-Protein;analog;Beverages;Blood brain barrier dysfunction;Blood capillaries;Brain;burden of illness;cerebral capillary;Characteristics;clinically relevant;Cognition;Cognitive;Cognitive deficits;cognitive enhancement;Data;Development;drinking water;Dust;Endocrine disruption;Endocrine Disruptors;Environment;Environmental Impact;Environmental Risk Factor;Estrogen Receptor 2;exposed human population;Exposure to;Extravasation;FDA approved;Food;Fulvestrant;Functional disorder;Health;Human;human tissue;Impaired cognition;Impairment;in vivo;in vivo Model;Individual;innovation;Knockout Mice;Knowledge;Link;Medical Device;Mission;Monkeys;Mus;National Institute of Environmental Health Sciences;National Institute of Neurological Disorders and Stroke;Nerve Degeneration;neuron development;Outcome;Oxidative Stress;Paper;Pathologic;Pharmaceutical Preparations;PIK3CG gene;Plastics;pre-clinical;Public Health;repaired;Research;Risk Factors;Rodent;Sampling;Signal Transduction;Soil;Testing;Time;Tissue Sample;Work

PROJECT_TITLE: Bisphenol-Induced Blood-Brain Barrier Dysfunction in Alzheimer’s Disease

STUDY_SECTION: CDIN

STUDY_SECTION_NAME: Chronic Dysfunction and Integrative Neurodegeneration Study Section[CDIN]


NIH_SPENDING_CATS: Biomedical Imaging;Biotechnology;Cancer;Digestive Diseases;Immunotherapy;Pancreatic Cancer;Precision Medicine;Rare Diseases;Skin Cancer

PHR: PROJECT NARRATIVE Core B interacts with each of the Program Projects to provide biological models, multiplexed in vivo optical biopsy, molecular pathology, and biostatistics support that are essential for the Projects to be successful in optimizing photodynamic priming of cancer immunotherapy to suppress the primary tumor (local control) as well as to shrink distal metastatic tumors while reducing costs and lowering the toxic side-effects of immune checkpoint inhibitors. The Core integrates newly developed biological models of the tumor immune microenvironment of skin and pancreatic cancer with novel tools and approaches for in vivo imaging, ex vivo microscopy, and ex vivo biochemical assays to enable therapeutic discovery and precise timing for administration of immune checkpoint inhibitors. Because the in vivo imaging technologies are conducive to integration with clinical endoscopy, the long-term impact of Core B is not only to stimulate and to support new research but also there is real potential to produce clinical translation of these precision medicine approaches.

PI_NAMEs: SPRING, BRYAN QUILTY (contact)

PROJECT_TERMS: Acceleration;Animal Model;Basal cell carcinoma;Biochemical;Biological Assay;biological development;Biological Markers;Biological Models;Biometry;Biostatistics Core;cancer cell;cancer imaging;cancer immunotherapy;Cancer Model;cell type;central database;checkpoint inhibition;Clinic;Clinical;clinical translation;Communication;Computer Analysis;Computer software;cost;Cost Savings;Custom;Data Collection;data management;data sharing;design;Development;Distal;Drug Delivery Systems;Endoscopy;Enzyme-Linked Immunosorbent Assay;experience;Experimental Designs;fabrication;flexibility;Fluorescence;Funding;General Hospitals;Gold;Histology;Histopathology;Human Resources;Image;image guided;Imaging technology;Immune;Immune checkpoint inhibitor;Immune response;Immunocompetent;Immunohistochemistry;improved;In Situ;In Vitro;in vivo;in vivo evaluation;in vivo imaging;in vivo Model;individualized medicine;Infrastructure;Institution;instrumentation;Laboratories;Location;lymph nodes;Lymphocyte;Malignant neoplasm of pancreas;Malignant Neoplasms;Maps;Massachusetts;medical schools;Methods;microendoscope;microendoscopy;Microscopy;Modeling;molecular pathology;Monitor;mouse model;Neoplasm Metastasis;novel;Operative Surgical Procedures;Optical Biopsy;Organoids;Pancreas;pancreatic cancer patients;Pathologic;Pathologist;Pathology;Patients;Peripheral;peripheral blood;personalized medicine;Pharmacotherapy;Phenotype;Population;pre-clinical;Pre-Clinical Model;precision medicine;premalignant;Primary Neoplasm;programs;Proteins;Protocols documentation;Quality Control;Quality of life;Reagent;Regimen;Reproducibility;Research;research and development;Research Personnel;Residual Cancers;Resources;Services;side effect;Skin;skin biopsy;Skin Cancer;specific biomarkers;Specimen;Statistical Data Interpretation;success;System;Techniques;Technology;Testing;Therapeutic;therapy development;three dimensional cell culture;three-dimensional modeling;Time;Tissues;tool;Toxic effect;Treatment outcome;treatment response;tumor;Tumor Markers;tumor-immune system interactions;Tumor-infiltrating immune cells;Universities;Validation;Visualization;web site;Work

PROJECT_TITLE: Core B: Biological Models, Multiplexed Optical Biopsy, Molecular Pathology, and Biostatistics Core


ADMINISTERING_IC: EB

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Brain Disorders;Cerebrovascular;Digestive Diseases;Gene Therapy;Genetics;Immunotherapy;Lung;Stroke

ORG_CITY: BERKELEY

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

ORG_STATE: CA

PHR: Project Narrative We aim to dramatically improve the spatial resolution of an innovative medical imaging technique called Magnetic Particle Imaging (MPI), which has already shown extraordinary promise for noninvasive, rapid, and zero-radiation scans of targeted tracers with ideal contrast and SNR. The PI’s lab at UC Berkeley has pioneered MPI scanner design, MPI fast image reconstruction algorithms, and biomedical appli- cations like tracking CAR-T therapies, early detection of GI bleeds, cancers, strokes and pulmonary embolisms. In a Bioengineering Partnership with the MPI Industry leader, Magnetic Insight, three re- search groups at UC Berkeley plan to improve MPI’s spatial resolution 10-fold in each dimension, which will finally enable the first human clinical MPI scanners.

PI_NAMEs: CONOLLY, STEVEN M (contact);GOODWILL, PATRICK

PROGRAM_OFFICER_NAME: ATANASIJEVIC, TATJANA

PROJECT_TERMS: 3-Dimensional;Academia;Adoption;Aftercare;Algorithms;Back;Binding;biomaterial compatibility;Biomedical Engineering;Blood Vessels;CAR T cell therapy;Cardiovascular Diseases;Caring;Cell Physiology;Cell Survival;Cells;Chemistry;chimeric antigen receptor natural killer cells;chimeric antigen receptor T cells;Clinical;Clinical Trials;Collaborations;cost;Data;design;Development;Dextrans;Diagnosis;Dimensions;Discipline of Nuclear Medicine;Early Diagnosis;Emergency Situation;Engineering;Ensure;experience;experimental study;follow-up;Fostering;Gastrointestinal Hemorrhage;Goals;Grant;Homing;Hour;Human;Image;image reconstruction;imaging capabilities;Imaging Device;Imaging Techniques;Imaging technology;Immunotherapy;improved;in vivo;Industrialization;Industry;innovation;insight;Life;Lung;Magnetic Resonance Imaging;Magnetism;Malignant neoplasm of gastrointestinal tract;Malignant Neoplasms;Medical Imaging;Modeling;Multiple Partners;nanoscale;Noise;non-invasive imaging;particle;Patients;Perfusion;personalized immunotherapy;personalized medicine;PET/CT scan;Physics;Physiologic pulse;Preclinical Testing;Process;Production;Pulmonary Embolism;Radiation;Radiation Dose Unit;reconstruction;Research;Resolution;RF coil;Safety;scale up;Scanning;single photon emission computed tomography;Software Tools;Solid Neoplasm;Stroke;targeted agent;Time;tool;Tracer;Traumatic Brain Injury;tumor;Tumor Volume

PROJECT_TITLE: Ten-Fold Resolution Boost for Magnetic Particle Imaging with Applications to Rapid, Non-Invasive Imaging of CAR-T Cell Therapies, Stroke, GI Bleeds and Pulmonary Embolisms

STUDY_SECTION: ITD

STUDY_SECTION_NAME: Imaging Technology Development Study Section[ITD]


ADMINISTERING_IC: MH

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences

ORG_CITY: EUGENE

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF OREGON

ORG_STATE: OR

PHR: PROJECT NARRATIVE The ability to adapt ongoing behaviors in dynamic environments is impaired across many neuropsychiatric disorders. The lateral habenula performs computations that compare past outcomes to current outcomes in order to drive reward-guided decision making. The proposed project will inform a richer, cell type-specific model of how lateral habenula neuronal subpopulations monitor past outcomes to guide flexible behavior.

PI_NAMEs: SUZUKI, KANA  (contact)

PROGRAM_OFFICER_NAME: VAN'T VEER, ASHLEE VICTORIA

PROJECT_TERMS: Adaptive Behaviors;Adverse effects;Aggressive behavior;Animals;Automobile Driving;Aversive Stimulus;Behavior;Behavior Therapy;Behavioral;behavioral impairment;Brain;cell type;Cells;Choice Behavior;Clinical;Code;Data;Decision Making;Disease;effective therapy;Electrophysiology (science);Elements;Emotional;Environment;Exhibits;expectation;experimental study;Feedback;Fiber;flexibility;Fright;Future;Goals;Habenula;Heterogeneity;Human;Impairment;improved;in vivo;Individual;individualized medicine;insight;Lateral;Learning;Mental Depression;Modeling;Molecular;Monitor;Motivation;Mus;Neurons;neuropsychiatric disorder;Obsessive-Compulsive Disorder;optogenetics;Outcome;pharmacologic;Photometry;Play;Population;Primates;Probability;Process;Psychological reinforcement;Rattus;response;Reversal Learning;reward processing;Rewards;Role;Schizophrenia;side effect;Signal Transduction;social;Specificity;Stimulus;Stress;Structure;Tachykinin;targeted treatment;Task Performances;Testing;Therapeutic Intervention;Update;Work

PROJECT_TITLE: Functional role of tachykinin 1-expressing lateral habenula neurons in flexible reward-guided behavior

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F02A-W(20)]


PHR: NARRATIVE The central goal of the core to service the projects with measurement tools that they can use to control the individualization of treatment, and while they may be imperfect markers, they can provide guidance as to the optimal way to have synergistic combination treatments.

PI_NAMEs: POGUE, BRIAN WILLIAM (contact)

PROJECT_TERMS: Aftercare;Algorithms;angiogenesis;Automobile Driving;Biochemical;Biological;Biological Assay;Biological Response Modifier Therapy;Biophysics;Blood capillaries;cancer imaging;cancer infiltrating T cells;Cells;Cellular Infiltrate;Cellular Phone;Chemotherapy and/or radiation;Clinic;Clinical;clinical imaging;clinical translation;Collaborations;Collagen;Combined Modality Therapy;Complex;contrast enhanced computed tomography;cost;Data;Dermatologic;Dermatology;dosimetry;Edema;elastography;Endoscopic Ultrasonography;Extracellular Matrix;Feedback;Fiber;Fluorescence;fluorescence imaging;Fresh Tissue;Goals;Human;Image;image guided;Imaging Device;Immune;immune activation;Immune response;Immune signaling;Immune system;Immunotherapy;In Situ;in vivo;in vivo imaging;indexing;Individual;individualized medicine;Inflammation;innovation;Invaded;invention;Legal patent;Lesion;Light;Lymphocyte Activation;Lymphocytic Infiltrate;Magnetic Resonance Imaging;Malignant Neoplasms;Maps;Measurement;Measures;Molecular;molecular marker;Operative Surgical Procedures;Optics;Oxygen;Pancreatic Adenocarcinoma;Perfusion;PET/CT scan;Photosensitizing Agents;Physiological;Positron-Emission Tomography;pre-clinical;Pre-Clinical Model;preclinical study;Production;Prognosis;radiomics;recruit;response;response biomarker;Sampling;Scanning;Services;Signal Transduction;Singlet Oxygen;Surface;Surrogate Markers;synergism;System;T-Cell Activation;technological innovation;Technology;technology development;Testing;Texture;Time;tissue mapping;Tissues;tool;Translating;translational potential;tumor;usability;Validation;Variant;Visualization;Work;X-Ray Computed Tomography

PROJECT_TITLE: Core C: In vivo Imaging, Dosimetry and Sensing of Photodynamic-Immune Responses and Synergies


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Brain Disorders;Breast Cancer;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Headaches;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Mental Health;Migraine;Networking and Information Technology R&D (NITRD);Pain Research;Pediatric;Pediatric Cancer;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases;Suicide;Women's Health Research

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: Project Narrative Cincinnati Children's (CCHMC) proposes to join eMERGE IV by enrolling of local Cincinnati African-American newborn babies and their mothers with available fathers and brothers and sisters to develop predictions of their risk for Asthma, Atopic Dermatitis, Obesity, Hypercholesterolemia, Hypertension, Prematurity, and Breast Cancer (along with 15 disorders chosen by the eMERGE IV Network and disorders chosen by CCHMC Faculty) using genetic variation, environmental factors, and family history. We will test whether knowledge of having a higher genetic risk for these disorders will motivate closer adherence to health recommendations made to reduce disease risk.

PI_NAMEs: KOTTYAN, LEAH CLAIRE;MARTIN, LISA J;PROWS, CYNTHIA A. (contact)

PROGRAM_OFFICER_NAME: ROWLEY, ROBB KENNETH

PROJECT_TERMS: 7 year old;Acute Lymphocytic Leukemia;Adherence;Adolescent Psychiatry;Adult;African American;African American Women;Age;American;Ancillary Study;Asthma;Atopic Dermatitis;Attitude;biobank;Birth;Brothers;care providers;Caring;Child;Child Care;Child Health;Childhood;Classification;Clinic;clinical care;clinical decision support;cohort;Collection;Communities;Computerized Medical Record;Consensus;Data;data hub;data modeling;data quality;Disease;disease phenotype;disorder prevention;disorder risk;DNA;DNA analysis;DNA Repository;Electronic Health Record;electronic health record system;Electronic Medical Records and Genomics Network;Enrollment;Environmental Risk Factor;Ethical Issues;Faculty;Family;Family member;Fast Healthcare Interoperability Resources;Fathers;Feeling suicidal;Fetus;Future;Generations;Genetic Risk;Genetic Variation;Genome;genome wide association study;Genomic medicine;Genomics;Genotype;Goals;Health;Health Promotion;high risk;Hospitals;hypercholesterolemia;Hypertension;improved;Individual;Infant;Infrastructure;Institution;Intervention;Investments;Knowledge;Letters;life span;Machine Learning;Malignant Breast Neoplasm;Medical;Methods;Migraine;minority subjects;Mitochondrial DNA;Mothers;National Human Genome Research Institute;neonate;Newborn Infant;Obesity;Outcome;Parents;Pediatric Hospitals;Perception;Performance;Phenotype;polygenic risk score;preference;pregnant;premature;programs;Quality Control;Randomized;Recommendation;Recording of previous events;Records;recruit;Risk;Risk Estimate;Risk Management;risk mitigation;Risk Reduction;Sampling;Services;Siblings;Sister;Site;success;Suicide;support tools;System;Technology;Testing;tool;Update;Variant;Vision;Work

PROJECT_TITLE: Polygenic Risk Scores for Healthier African American Families


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Precision Medicine;Prevention;Rehabilitation;Stroke;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

PI_NAMEs: ROST, NATALIA S (contact)

PROJECT_TERMS: acute stroke;Award;Biological Markers;Blood Vessels;catalyst;Clinical;Clinical Data;clinical database;Clinical Markers;Clinical Research;clinical research site;Clinical Trials;cognitive disability;Collaborations;Communication;Communities;Complex;computational platform;Conceptions;Data;Data Collection;data management;Data Management Resources;Dementia;design;disability;Ensure;experience;Foundations;Funding;Future;Goals;health disparity populations;Human Resources;Image;imaging biomarker;Impaired cognition;Information Dissemination;Infrastructure;innovation;Institution;Intervention;Lead;Leadership;Measurable;Methods;Monitor;multimodality;National Institute of Neurological Disorders and Stroke;novel;Online Systems;operation;Patient Selection;Performance;personalized predictions;personalized strategies;Population;Population Heterogeneity;Positioning Attribute;post stroke;post stroke cognitive impairment;Prevention strategy;Process;Prognosis;Quality Control;Reaction Time;Recovery;recruit;rehabilitation strategy;repository;Research;Research Design;Research Personnel;Resource Allocation;Resources;Risk;Role;Science;Scientific Advances and Accomplishments;Site;Stroke;stroke cognitive outcome;stroke patient;stroke trials;Structure;success;therapy design;timeline;United States;United States National Institutes of Health;Work

PROJECT_TITLE: DISCOVERY - Administrative Core


NIH_SPENDING_CATS: Bioengineering;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Data Science;Dissemination and Implementation Research;Networking and Information Technology R&D (NITRD)

PI_NAMEs: CHEN, ELIZABETH S. (contact)

PROJECT_TERMS: Address;Adopted;Adoption;Agreement;Basic Science;Bioinformatics;biomedical informatics;Biometry;Businesses;Caring;Clinical;Clinical Research;Clinical Sciences;cohort;Collaborations;Communities;community engagement;Community Outreach;Competency-Based Education;Computer software;cyber infrastructure;Data;Data Analyses;Data Collection;data dissemination;data management;Data Science;Data Security;data sharing;data tools;design;Development;Directed Molecular Evolution;Education;Effectiveness;electronic health data;Ensure;Environment;Epidemiology;Evaluation;evidence base;Goals;Government;Health;Health Care Research;health data;Health Priorities;Healthcare Systems;improved;Informatics;informatics infrastructure;informatics training;innovation;Knowledge;Leadership;life span;Machine Learning;Maintenance;meetings;Mission;New England;open data;open source;Outcome;outreach services;Phase;Population;Population Heterogeneity;Population Sciences;preservation;Process;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Research Design;Research Personnel;research to practice;Resources;Rhode Island;Science;Services;skills;Software Tools;Source;Standardization;success;synergism;System;Technology;technology intervention;tool;Training;translational health science;Translational Research;translational scientist;Universities;usability;Vision

PROJECT_TITLE: Biomedical Informatics, Bioinformatics, and Cyberinfrastructure Enhancement Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Cardiovascular;Cerebrovascular;Dementia;Gene Therapy;Genetics;Neurodegenerative;Neurosciences;Pediatric;Prevention;Stroke;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

PHR: Narrative ACTA2 Multisystemic Smooth Muscle Dysfunction Syndrome is an ultra-rare disease with less than 50 known cases worldwide; it is caused by a specific genetic mutation in the ACTA2 gene that affects smooth muscle cells. Smooth muscle cells are found in many different organs in the body including the arteries, the gut, the eye, the bladder, and the intestines; some mutations can cause brain infarcts (strokes) and rupture of large artery and death in childhood. In this study we use a combination of cell and animal modeling studies to determine if we can improve the disorder through gene therapy.

PI_NAMEs: LINDSAY, MARK E;MUSOLINO, PATRICIA L (contact)

PROGRAM_OFFICER_NAME: MORRIS, JILL A

PROJECT_TERMS: Actins;adeno-associated viral vector;Adolescent;Affect;Age;Alleles;Anesthesia procedures;Animal Model;Aorta;Aortic Aneurysm;Arginine;Arteries;base editing;Behavioral;Biological Models;Bladder;Blood;Blood flow;Blood Pressure;Blood Vessels;Body System;Brain;brain abnormalities;Brain Infarction;Bundling;Cardiovascular Diseases;Carotid Arteries;Cell Line;Cell model;Cell Physiology;Cellular Assay;cerebral autoregulation;Cerebral small vessel disease;cerebrovascular;Cerebrovascular Circulation;Cerebrovascular Disorders;Cerebrovascular system;Cerebrum;Cessation of life;Characteristics;Child;Childhood;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Collagen;Complex;CRISPR/Cas technology;Custom;Data;Deposition;Development;Diagnosis;Dilatation - action;Disease;Disease Progression;DNA Sequence Alteration;Dominant-Negative Mutation;early onset;Elasticity;Elastin;Evaluation;Exhibits;experience;Eye;Functional disorder;functional outcomes;gene correction;Gene Targeting;gene therapy;Genes;genetic approach;Guide RNA;Heterozygote;Histidine;Histopathology;Home;human disease;Hypotension;Impaired cognition;Impairment;improved;In Vitro;in vivo;Infarction;Intestines;Ipsilateral;Ischemia;Ischemic Stroke;Knock-in;Knock-out;Lead;Life;Ligation;LoxP-flanked allele;Lung;Measures;Mediating;Medical;Microvascular Dysfunction;Modeling;Molecular;mortality;mouse model;Mus;Muscle;mutant;Mutation;Mydriasis;Natural History;Neurological disability;Neurology;neurovascular;neurovascular coupling;novel;Operative Surgical Procedures;Organ;Oxygen;palliate;Patent Ductus Arteriosus;Pathogenicity;Pathology;Patient observation;Patients;Performance;Pericytes;Phenotype;pre-clinical;predictive marker;Prevention;Publishing;Pupil;Rare Diseases;Recurrence;respiratory;Rupture;secondary endpoint;Shapes;Smooth Muscle;Smooth Muscle Myocytes;Stroke;Stroke prevention;Study models;Syndrome;System;Systemic blood pressure;Therapeutic;Uterus;Variant;vascular abnormality;Vascular Diseases;white matter injury;Woman

PROJECT_TITLE: Modeling and Therapeutic Approaches for Genetic Vasculopathies

STUDY_SECTION: BINP

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Genetics;Human Genome;Nutrition;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_DEPT: PATHOLOGY

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: PROJECT NARRATIVE Oral squamous cell carcinoma (OSCC) is a cancer with significant morbidity and mortality, and limited treatment options. In this study, we will examine how dietary restriction of serine impacts tumor growth, using OSCC cells and an OSCC mouse model. This research will give us better insight into the development of OSCC and may one day lead to more effective therapeutic options.

PI_NAMEs: JANKOWSKI, STACY  (contact)

PROGRAM_OFFICER_NAME: FUQUA, CHANTEL FAYSAN

PROJECT_TERMS: advanced disease;Alcohol consumption;Algorithms;alpha ketoglutarate;Anabolism;Anatomy;Biochemical;Biological;Biological Assay;cancer stem cell;cancer therapy;Carcinoma;Cell Communication;Cell Differentiation process;Cell Line;Cell Lineage;cell motility;Cells;chemotherapy;Chromatin;Chromatin Structure;Cleavage Under Targets and Release Using Nuclease;Clinical;Cluster Analysis;Complex;cost effective;Coupled;demethylation;deprivation;derepression;Development;dietary;Dietary Intervention;dietary restriction;Differentiated Gene;Differentiation Antigens;Dioxygenases;Environment;enzyme pathway;Enzymes;Epigenetic Process;epigenomic profiling;epigenomics;Epithelium;Evolution;Genes;Genomics;Global Change;Growth;Head and Neck Cancer;Heterogeneity;histone modification;Histones;HPV negative;Human;Immunofluorescence Immunologic;Immunohistochemistry;In Vitro;in vivo;insight;Invaded;Isogenic transplantation;Knowledge;Lead;Lysine;Malignant Epithelial Cell;malignant mouth neoplasm;Malignant Neoplasms;Mesenchymal;Messenger RNA;Metabolism;migration;Modeling;Modification;Morbidity - disease rate;Morphology;mortality;mouse model;mouth squamous cell carcinoma;Neoplasm Metastasis;neoplastic cell;novel;novel therapeutic intervention;novel therapeutics;Nuclear;Nutrient;Operative Surgical Procedures;Outcome;Pathway interactions;Patients;Pharmaceutical Preparations;Phenotype;Play;Population;precision nutrition;programs;Proliferating;Proliferation Marker;Proteins;Radiation therapy;Repression;Research;Resistance;response;Role;Science;Serine;side effect;Signal Pathway;single-cell RNA sequencing;Starvation;stem;stem cell genes;stem cell population;stemness;success;targeted treatment;Therapeutic;therapeutically effective;Tobacco use;trait;Transcription Initiation Site;treatment response;tumor;tumor growth;tumor heterogeneity;tumor progression;tumorigenic;uptake;Validation;Western Blotting;Withdrawal

PROJECT_TITLE: The role of serine metabolism on the evolution of oral squamous cell carcinoma

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences

ORG_CITY: ANN ARBOR

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE Our brains rely both on the segmentation of experience into distinct memories and on the integration of those episodic memories across space and time to inform our perception of the world and help us make decisions. Event boundaries are conceptual or physical boundaries such as reward locations or environment changes that can segment experience into distinct episodes. This project proposes a novel experimental design and set of analyses focused on illuminating how the hippocampus forms neural representations of segmented episodes through place cells, the firing of place-cell sequences during theta oscillations (“theta sequences”), and multi-neuronal replays during sharp-wave ripples, and how these representations and patterns are altered upon introduction of new event boundaries.

PI_NAMEs: WAHLBERG, RACHEL SOPHIA (contact)

PROGRAM_OFFICER_NAME: PINARD, COURTNEY ROSE

PROJECT_TITLE: Segmentation and integration of experience in hippocampal neuronal representations


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Disability Research;Health Services;Machine Learning and Artificial Intelligence;Pain Research;Patient Safety;Physical Rehabilitation;Rehabilitation

ORG_CITY: Columbus

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: OHIO STATE UNIVERSITY

PHR: PROJECT NARRATIVE Current standard of care for ventral hernia repair does not include objective measures of function or post- operative physical therapy, which may improve patient quality of life. This mentored training plan will use data from a CMS Qualified Clinical Data Registry and an NIH/NIDDK funded registry-based clinical trial (R01DK131207) to understand the complex relationships between patient- and surgical-characteristics as they relate to post-operative function. Findings from this fellowship will provide (1) robust predictive models to understand characteristics of patients who have a good or poor self-reported quality of life 1 year after ventral hernia repair and (2) foundational evidence in understanding treatment response to physical therapy using objective measures of function.

PI_NAMEs: ARHOS, ELANNA  (contact)

PROGRAM_OFFICER_NAME: DENSMORE, CHRISTINE L

PROJECT_TERMS: Abdomen;abdominal wall;Activities of Daily Living;Acute;Address;career;Characteristics;Chronic;Clinical;Clinical Data;Clinical Trials;cohort;Complex;cost;Country;Data;data registry;data standards;Development;disability;Disease;Ensure;Environment;evidence base;Expenditure;experience;Faculty;Fellowship;Female;follow-up;functional outcomes;Funding;Goals;healing;Health;health care model;Healthcare;Healthcare Systems;Hernia;Impairment;improved;Individual;insight;Intervention;Investigation;Knowledge;Link;Machine Learning;machine learning algorithm;Measures;meetings;Mentors;model building;Morbidity - disease rate;Musculoskeletal System;National Institute of Diabetes and Digestive and Kidney Diseases;novel;Operative Surgical Procedures;Outcome;Outcome Measure;Pain management;Parents;Patient Care;Patient Outcomes Assessments;Patient Self-Report;Patient-Focused Outcomes;Patients;Perioperative Care;Persistent pain;physical impairment;Physical therapy;Physicians;Positioning Attribute;Postoperative Care;Postoperative Pain;Postoperative Period;Pragmatic clinical trial;pre-doctoral;predictive modeling;Preparation;prevent;Prognosis;Prognostic Factor;Publishing;Qualifying;Quality of life;Recovery;Recovery of Function;Recurrence;Registries;Rehabilitation therapy;repaired;Reporting;Research;Research Personnel;restoration;Risk;Sampling;Scientist;Site;skills;standard of care;Standardization;Subgroup;Surgeon;Therapeutic;Therapeutic Intervention;Time;Training;treatment arm;treatment response;United States;United States National Institutes of Health;Universities;Ventral Hernia;Work

PROJECT_TITLE: Towards Precision Rehabilitation for Ventral Hernia


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Neurodegenerative;Neurosciences;Stroke

PI_NAMEs: GOTTESMAN, REBECCA F (contact)

PROJECT_TERMS: acute stroke;Address;adjudication;Atherosclerosis Risk in Communities;Biological Markers;Biometry;Blood Vessels;Classification;clinical research site;Cognition;Cognitive;cognitive ability;cognitive change;cognitive performance;cognitive testing;cohort;Collaborations;Communication;Data;deep learning;Dementia;design;Development;Disease;Disparity population;Educational Status;Ensure;Evaluation;Event;follow-up;Genetic;Goals;high risk;Impaired cognition;insight;Link;Machine Learning;Magnetic Resonance Imaging;Measurement;Measures;Methodology;Methods;mild cognitive impairment;multimodality;Neurocognitive;neuroimaging;novel;novel marker;operation;Outcome;Outcome Assessment;Participant;Pathology;Performance;Persons;Population;Positron-Emission Tomography;post stroke;predictive modeling;Public Health;quality assurance;Quality Control;Recovery;Reporting;Research Design;Research Personnel;Risk Factors;Sample Size;Sampling;Site;Socioeconomic Factors;Statistical Data Interpretation;statistics;Stroke;stroke cognitive outcome;stroke event;stroke patient;Structure;Techniques;Telephone;Time;Validation;Visit;Work

PROJECT_TITLE: DISCOVERY - Statistics and Analysis Core


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

ORG_CITY: OKLAHOMA CITY

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PHR: NARRATIVE Overall The P30 Vision Cores provide state-of-the-art facilities for clinically relevant research of the causes and treatments of blinding eye diseases. Our proposal fulfills the mission of NEl P30 funding because it will support the research of 16 health-related NEI-funded R01 grants held by 13 talented and productive investigators. The core modules will increase the productivity of current investigators, facilitate recruitment of new investigators, and stimulate the development of collaborative translational research projects.

PI_NAMEs: CALLEGAN, MICHELLE C (contact)

PROGRAM_OFFICER_NAME: GOVER, TONY DOUGLAS

PROJECT_TERMS: Achievement;active vision;Address;Animal Experimentation;animal imaging;Area;Award;career;Cellular biology;cellular imaging;Center Core Grants;clinically relevant;Collaborations;Competence;Computer software;Core Facility;Core Grant;data acquisition;Development;disease model;Doctor of Philosophy;Environment;Equipment;Eye diseases;Faculty;Faculty Recruitment;Fostering;Foundations;Funding;Genotype;Goals;graduate student;Grant;Health;Health Sciences;Human Resources;Image;imaging modality;Immune;Immune response;Immunobiology;Immunologics;Immunology;Individual;Inherited;innovation;instrumentation;interest;Laboratories;Laboratory Research;Measures;Medical Research;Microbiology;Mission;non-invasive imaging;Nursing Faculty;Oklahoma;Ophthalmology;Outcome;Paper;Physiology;Play;Postdoctoral Fellow;Productivity;professor;programs;Progress Reports;Publications;Qualifying;rapid growth;recruit;Research;Research Infrastructure;Research Personnel;Research Project Grants;Research Support;Resources;Retinal Degeneration;Retinal Diseases;Role;Scientist;Services;Solid;Specialist;System;Talents;Technology;Testing;Training;Translational Research;Universities;Update;Vision;Vision research;vision science

PROJECT_TITLE: P30 Center Core Grant for Vision Research


ADMINISTERING_IC: HL

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease;Prevention

ORG_CITY: LOS ALTOS

ORG_NAME: CARDIAC RSK3 INHIBITORS, LLC

PHR: Heart failure is a syndrome of major public health significance that contributes to the death of about 1 in 8 Americans. Despite a range of existing therapies, the mortality rate for patients with heart failure is high, with nearly 50% of patients dying within 5 years of a diagnosis. In this application, we aim to develop a new therapy for heart failure based upon selectively targeting the anchoring of RSK3 to the scaffold protein mAKAPβ.

PI_NAMEs: CIVIDINI, FEDERICO  (contact)

PROGRAM_OFFICER_NAME: SCHWARTZ, LISA

PROJECT_TERMS: A kinase anchoring protein;Affinity;American;Animal Model;Animals;Apoptosis;Attenuated;Binding;Biodistribution;Biological;Biotechnology;Body Weight;Cardiac;cardiac magnetic resonance imaging;Cardiac Myocytes;Cardiovascular Diseases;Catheterization;cellular pathology;Cessation of life;Chronic;Circulation;Clinical Trials;clinically relevant;comparison control;coronary fibrosis;Data;Death Rate;Dependovirus;Development;Diagnosis;Disease;Dose;Echocardiography;Enhancers;Enzymes;Family;Family suidae;Fibrosis;first-in-human;Gene Transduction Agent;Heart;Heart failure;heart failure with reduced ejection fraction;heart function;heart preservation;hemodynamics;Histologic;Hypertrophy;improved;Infarction;Infusion procedures;inherited cardiomyopathy;inhibitor;ischemic cardiomyopathy;Laboratories;Left;Left Ventricular Ejection Fraction;Left ventricular structure;Legal patent;Mediating;member;Modeling;Molecular Analysis;molecular pathology;Morbidity - disease rate;mortality;mouse model;Mus;Muscle;Muscle Cells;Muscle Proteins;Myocardial Infarction;Myocardial Ischemia;Myocardium;N-terminal;novel strategies;novel therapeutic intervention;novel therapeutics;Nuclear;Pathologic;Pathway interactions;patient population;Patients;Penetrance;Peptides;pharmacologic;Phase;Physiologic intraventricular pressure;polypeptide;porcine model;Predisposition;pressure;prevent;Prevention;Prevention approach;primary endpoint;Procedures;promoter;Protein Kinase;protein protein interaction;Public Health;Publishing;Quality of life;Reperfusion Injury;Research;restoration;Ribosomal Protein S6 Kinase;Ribosomes;Risk;RPS6KA gene;Safety;scaffold;Scaffolding Protein;secondary endpoint;Serotyping;Signal Transduction;Small Business Innovation Research Grant;Specificity;Stroke Volume;Structure;Syndrome;Tertiary Protein Structure;Testing;therapeutic target;Tissues;Toxicology;Viral Genome;Work

PROJECT_TITLE: RSK3 Anchoring Disruptor Therapy for Heart Failure


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Epilepsy;Health Services;Neurodegenerative;Neurosciences;Patient Safety;Physical Injury - Accidents and Adverse Effects;Prevention;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

PHR: NARRATIVE Anti-seizure medications are commonly prescribed to older adults after traumatic brain injury, but these drugs may not be necessary, or the harms could outweigh the benefits particularly among those with dementia. There is limited rigorous evidence guiding when and how physicians should prescribe this type of treatment. This project will use the real-world experience of millions of Medicare beneficiaries to generate this evidence and inform both policy and future clinical decisions.

PI_NAMEs: MOURA, LIDIA MARIA VERAS ROCHA DE (contact);ZAFAR, SAHAR F

PROGRAM_OFFICER_NAME: BAKOS, ALEXIS DIANE

PROJECT_TERMS: Acute;Address;administrative database;Admission activity;Adverse effects;Adverse event;adverse event risk;Age;Algorithms;Alzheimer's disease related dementia;Alzheimer's disease risk;analytical tool;Anticonvulsants;beneficiary;Caring;cerebrovascular;classification algorithm;Clinical;clinical care;Clinical Trials;Cognitive;cohort;comorbidity;comparative effectiveness study;comparative safety;cost;Data;Data Set;Data Sources;Dementia;dementia care;design;Diagnosis;disease classification;Drug usage;Effectiveness;Electronic Health Record;Emergency Situation;Equilibrium;Ethnic Origin;Event;experience;fall injury;falls;Family;Formularies;Future;Glasgow Coma Scale;Goals;Guidelines;Health;Health system;Heterogeneity;high risk;human old age (65+);Impaired cognition;improved;Incentives;Incidence;Individual;Inpatients;Institutionalization;large datasets;Levetiracetam;Life;Link;Literature;Machine Learning;Marketing;Measures;medical specialties;Medicare;Medicare claim;Medicare/Medicaid;Metabolism;Minority Groups;modifiable risk;mortality;Natural experiment;neurotransmitter release;novel;Observational Study;older adult;Outcome;Pathway interactions;patient population;Patients;Pharmaceutical Preparations;Phenytoin;Physicians;Policies;Policy Maker;Population;Predisposition;programs;Prophylactic treatment;public health priorities;Quality of life;Race;Recommendation;recruit;Registries;Risk;Risk Factors;Safety;safety study;Science;Seizures;Serious Adverse Event;Severities;sex;side effect;Sodium Channel Blockers;Synapses;TBI Patients;Testing;Traumatic Brain Injury;treatment effect;Treatment Effectiveness;treatment strategy;Uncertainty;Uninsured Medical Expense;Visit;Work;young adult

PROJECT_TITLE: Traumatic Brain Injury Anti-Seizure Prophylaxis in the Medicare Program

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HSS-P(90)S]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biotechnology;Brain Disorders;Cardiovascular;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurodegenerative;Neurosciences;Orphan Drug;Pediatric;Rare Diseases

ORG_CITY: WINSTON-SALEM

ORG_DEPT: NEUROLOGY

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

ORG_STATE: NC

PHR: We seek to continue Wake Forest NeuroNEXT as a high performing NeuroNEXT Network (NN) Clinical Site that has rapidly opened, enrolled, and contributed to NN trials. Since our initial award in 2018, Wake Forest Baptist Health entered into a strategic partnership with Atrium health to expand our already diverse catchment to include 40 hospitals, 1,200 care locations, and >7 million patients. We will continue to (1) rapidly rollout trials, (2) expand access to diverse populations in the southeast United States, (3) contribute to improved trial efficiency through the network, and (4) train the next generation of clinical trialists in adult & pediatric neurology.

PI_NAMEs: EZZEDDINE, MUSTAPHA AHMAD (contact);STROWD, ROY ERVIN

PROGRAM_OFFICER_NAME: OHAYON, JOAN M

PROJECT_TERMS: Adult;Alabama;Alzheimer's Disease;Alzheimer's Disease Core Center;American;Award;Baptist Church;Capsicum;career;career development;Caring;Cell Therapy;Childhood;Clinical;clinical epidemiology;Clinical Research;clinical research site;Clinical Sciences;clinical trial participant;Clinical Trials;Cohort Studies;Collaborations;Conduct Clinical Trials;Country;Data;Data Coordinating Center;data integrity;data management;Dedications;design;Development;District of Columbia;drug discovery;Economically Deprived Population;Enrollment;Ensure;Ethnic Origin;experience;Faculty;Fellowship;Fellowship Program;Female;Funding;Future;gene therapy;Gene therapy trial;General Practitioners;Geography;Goals;Growth;Health;Health Sciences;Health system;Heart Atrium;Hispanic;Home;Hospitals;improved;Incentives;Infrastructure;infrastructure development;Institution;Interdisciplinary Study;Lead;Leadership;Learning;Location;medical schools;Mentors;Mentorship;Minority Enrollment;minority patient;Mission;Multi-Institutional Clinical Trial;multidisciplinary;Nervous System Disorder;Neurologist;Neurology;Neurosciences;next generation;North Carolina;novel strategies;Occupational activity of managing finances;organizational structure;outreach;Participant;participant enrollment;Patient Care;patient retention;Patients;Pediatric Hospitals;Pediatric Neurology;peer;Performance;Persons;Population Heterogeneity;Positioning Attribute;pre-clinical;Procedures;Process;programs;Protocols documentation;Public Health;Rare Diseases;recruit;Regenerative Medicine;remote consent;Reporting;Reproducibility;Research;Research Design;Research Infrastructure;Research Personnel;Resources;Secure;senior faculty;Site;socioeconomic disadvantage;Solid;South Carolina;Southeastern United States;Specialist;Specimen;success;System;Therapeutic Studies;Training;Training Programs;translational pipeline;Translational Research;translational scientist;Underrepresented Populations;Underserved Population;United States;Universities;Woman

PROJECT_TITLE: Wake Forest NeuroNext Clinical Site (WAKENN)


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

PROJECT_TERMS: Advisory Committees;Center Core Grants;Communication;Contract Services;Core Facility;Core Grant;Ensure;Equipment;Funding;Health Sciences;Laboratories;meetings;member;National Eye Institute;Oklahoma;operation;Ophthalmology;Reporting;Research Personnel;Services;Universities;Vision;Vision research


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Stroke;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

PI_NAMEs: MESCHIA, JAMES F (contact)

PROJECT_TERMS: Acute;acute stroke;Address;Affect;Alzheimer's Disease;Aneurysmal Subarachnoid Hemorrhages;Biological;Biological Markers;Blood Vessels;Brain Pathology;Cerebral hemisphere hemorrhage;cerebrovascular;Cerebrovascular Disorders;Cessation of life;Charge;Clinical;Clinical Data;clinical predictors;clinical research site;Clinical Trials;Cognitive;cognitive recovery;cohort;Committee Members;Communities;comorbidity;Dementia;dementia risk;design;disability;Disease;Enrollment;Ethnic Origin;Ethnic Population;Etiology;experience;Formulation;Funding;Goals;health disparity populations;Hospital Records;Hospitals;Human Resources;Image;Impaired cognition;Intervention;Ischemic Stroke;Knowledge;Lead;Leadership;Modeling;National Institute of Neurological Disorders and Stroke;novel;novel therapeutics;operation;Outcome;Outcome Assessment;Participant;participant enrollment;Patient Admission;Patient Recruitments;patient retention;Patients;Performance;performance site;Phase;Phenotype;Population;post stroke;post stroke cognitive impairment;prevent;Prevention;Process;programs;Quality Control;Race;racial population;randomized trial;Recovery;recruit;repository;Resources;Site;Stroke;stroke cognitive outcome;stroke patient;success;Techniques;Telephone;Testing;Training Activity;Update;Vulnerable Populations

PROJECT_TITLE: DISCOVERY - Recruitment and Retention Core


NIH_SPENDING_CATS: Biomedical Imaging;Eye Disease and Disorders of Vision;Neurosciences

PI_NAMEs: RAJALA, RAJU VS (contact)

PROJECT_TERMS: Animal Experimentation;animal imaging;Animal Model;animal model development;Animals;Area;Breeding;Center Core Grants;Collaborations;Core Grant;dark rearing;Data;Data Analyses;Data Collection;Dedications;disease model;Electrophysiology (science);Electroretinography;Environment;Equipment;experimental analysis;experimental study;Eye diseases;Faculty;Fostering;Funding;Genotype;Glaucoma;graduate student;Grant;Guidelines;Health Sciences;Housing;Human Resources;Humidity;Hyperoxia;Hypoxia;Image;in vivo;Infection;Inflammation;instrument;instrumentation;Laboratories;laser photocoagulation;Light;Location;Microscopy;Modeling;Mus;Oklahoma;Ophthalmoscopy;Optical Coherence Tomography;Pathogenesis;Physiology;Postdoctoral Fellow;recruit;Reproducibility;Research;Research Personnel;Scientist;skills;System;Therapeutic;tonometry;Training;Training and Education;Transgenic Animals;Universities;user-friendly;Vision;vision development;Vision research


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Data Science;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: PITTSBURGH

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Single cell genomics data have become indispensable tools in studying physiological and pathological processes, and a grant challenge is to extract quantitative mechanistic information from the snapshot data. Our proposed research will develop a computational framework to reconstruct dynamical information from single cell genomics data. The research will provide a quantitative framework for extracting mechanistic information from single cell data that can guide on controlling cellular processes for biomedical purposes.

PI_NAMEs: XING, JIANHUA  (contact)

PROGRAM_OFFICER_NAME: WANG, PEGGY

PROJECT_TERMS: Address;Algorithms;ATAC-seq;Benchmarking;Binding Sites;Biochemical;Biological Models;Biology;Birth;Cell Fate Control;Cell Physiology;Cells;Cellular biology;Cessation of life;cofactor;combinatorial;Communities;Complex;computational pipelines;computer framework;computerized tools;Computers;CRISPR interference;Data;data acquisition;Data Analyses;data integration;Data Set;data space;Development;differential geometry;Dimensions;DNA Binding;DNA sequencing;Dose;dynamic system;Elements;environmental change;Equation;Error Sources;Eukaryotic Cell;experimental study;extracellular;GATA1 gene;Gene Expression;Gene Expression Regulation;gene regulatory network;Genes;Genetic;Genetic Code;Genetic Transcription;genome-wide;Genomic approach;genomic data;Goals;Grant;Graph;high dimensionality;improved;in silico;Informatics;informatics tool;insight;Knowledge;Label;Learning;LMO2 gene;Machine Learning;mathematical model;Mathematics;Measurement;Metabolic;Methods;Modality;Modeling;molecular dynamics;multimodal data;Mutation;Names;Nature;Pathologic Processes;Pattern;Physiological Processes;predictive modeling;Procedures;Process;Publishing;reconstruction;Regulation;Research;response;RNA;RNA Splicing;Sampling;single cell analysis;single cell genomics;statistics;Stochastic Processes;success;Systems Biology;Systems Theory;TAL1 gene;Techniques;Testing;Time;tool;tool development;transcription factor;transcriptome;transcriptomics;vector;Work

PROJECT_TITLE: Learn Systems Biology Equations From Snapshot Single Cell Genomic Data

STUDY_SECTION: GCAT

STUDY_SECTION_NAME: Genomics, Computational Biology and Technology Study Section[GCAT]


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Machine Learning and Artificial Intelligence;Maternal Health;Maternal Morbidity and Mortality;Networking and Information Technology R&D (NITRD);Nutrition;Pediatric;Pregnancy;Women's Health Research

ORG_CITY: Newark

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: PROJECT NARRATIVE The placenta delivers nutrients to the baby and protects against damage from medications and toxicants. We will develop new scientific approaches to study how chemicals pass across the placenta aided by transporter proteins and train scientists and clinicians at the intersections of pharmacology, chemistry, computer science, public health, medicine, and bioengineering.

PI_NAMEs: ALEKSUNES, LAUREN M (contact);HUH, DONGEUN ;ZHU, HAO

PROGRAM_OFFICER_NAME: WEINBERG, DAVID H

PROJECT_TERMS: ABCG2 gene;Acceleration;Active Biological Transport;Address;Applications Grants;ATP-binding cassette transport;ATP-Binding Cassette Transporters;Binding;Biology;Biomedical Engineering;Birth;career;Carrier Proteins;Cells;Chemicals;Chemistry;Clinical;Clinical Research;cohort;Computational Biology;Computer Models;computer science;Data;Data Set;Databases;deep learning;deep neural network;demographics;dietary supplements;Discipline of obstetrics;Disease;doctoral student;drug disposition;drug efficacy;Endothelial Cells;Engineering;Ensure;Epidemic;Epidemiology;Exclusion;extracellular vesicles;fetal;Fetal Development;Fetus;Fibroblasts;Genetic;Goals;Government;Growth;health of the mother;Healthcare;Healthy People 2020;Hormones;Human;improved;in silico;In Vitro;in vivo;Infant;Infrastructure;inhibitor;innovation;Institution;Intervention;knowledgebase;Machine Learning;Maternal Health;Maternal Health Services;maternal morbidity;Maternal Mortality;Maternal-fetal medicine;Measures;Medicine;microphysiology system;Modeling;novel;novel strategies;Nutrient;nutrition;Outcome;Pathologic;Pathology;Perinatal;perinatal health;Pharmaceutical Preparations;pharmacokinetic model;pharmacologic;Pharmacologic Substance;Pharmacology;Pharmacotherapy;Placenta;placental transfer;Postdoctoral Fellow;Pregnancy;Pregnant Women;Property;Proteins;Proteomics;Public Health;Regulation;Research;Research Personnel;Resources;Risk Assessment;Scientist;sex;SLC2A1 gene;solute;success;synergism;System;Testing;Therapeutic;Therapeutic Intervention;Three-Dimensional Imaging;Toxic effect;toxicant;Toxicant exposure;Training;training opportunity;Translational Research;trophoblast;undergraduate student;Vascularization;web portal;Xenobiotics

PROJECT_TITLE: Integrated Transporter Elucidation Center


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Clinical Research;Data Science;Dementia;Networking and Information Technology R&D (NITRD);Stroke

PI_NAMEs: HELMER, KARL GERARD (contact)

PROJECT_TERMS: Address;Adherence;Agreement;Alzheimer's Disease;Assessment tool;Authorization documentation;Biological Markers;Biological Specimen Banks;Blood Vessels;Clinical;Clinical assessments;Clinical Research;Clinical Trials;cohort;Common Data Element;Communities;Data;data access;data exchange;data handling;data integration;data integrity;data management;data quality;data quality/integrity;data reuse;Data Set;data sharing;Development;experience;FAIR principles;Funding;Future;Grant;Human Resources;Image;Infrastructure;Institution;interest;interoperability;Leadership;Metadata;multimodal data;ontology development;Process;quality assurance;Recovery;Regulation;repository;repository infrastructure;Resources;Role;Services;Site;Stroke;stroke cognitive outcome;System;Systems Integration;tool;United States National Institutes of Health;web interface;web portal;Work

PROJECT_TITLE: DISCOVERY - Repository Core


NIH_SPENDING_CATS: Bioengineering;Eye Disease and Disorders of Vision

PI_NAMEs: ELLIOTT, MICHAEL H (contact)

PROJECT_TERMS: 3-Dimensional;cellular imaging;Center Core Grants;Collaborations;Computer software;confocal imaging;Core Facility;Creativeness;cryostat;digital imaging;Equipment;Eye;Fostering;Functional disorder;Funding;Grant;Guidelines;Health Sciences;Histologic;Histology;Hour;Image;imaging modality;imaging system;innovation;Label;Laboratories;Laboratory Research;Lasers;microscopic imaging;Microtome - medical device;Oklahoma;Paraffin;Physiology;Postdoctoral Fellow;Principal Investigator;Productivity;programs;Publications;Research;Research Personnel;Resolution;Resources;Scanning;Sepharose;Services;Slide;Stains;student training;Tissues;Training;Training and Infrastructure;Universities;Vision;Vision research


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Infectious Diseases;Sexually Transmitted Infections;Topical Microbicides;Women's Health Research

ORG_CITY: PASADENA

ORG_NAME: AURITEC PHARMACEUTICALS, INC.

PHR: NARRATIVE The broad, long-term goal of this project is to develop a pritelivir intravaginal ring (IVR) for the treatment and pre-exposure prophylaxis of genital herpes, a common problem that affects millions of Americans. On average, recurrences occur 4 times a year, and infection is life-long. Pritelivir is a promising α-helicase inhibitor that has proved superior to existing therapies in Phase 2 clinical testing, but whose clinical development as a systemic therapy has been slowed due to observed unexplained systemic toxicity in primates. Local therapy is therefore of special interest. Using our proprietary Versa technology platform, we have developed an intravaginal ring (IVR) formulation of pritelivir. The goal of this Phase IIB SBIR proposal is to follow the FDA-instructed nonclinical activities and achieve an Investigational New Drug (IND) allowance in pursuit of clinical testing of our pritelivir IVR product in humans.

PI_NAMEs: SHAH, SARJAN ;SMITH, THOMAS J. (contact)

PROGRAM_OFFICER_NAME: GLOCK, JONATHAN A

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Acyclovir;Affect;American;analytical method;Animal Model;Animals;Anti-viral Agents;Area;Chemistry;Clinical;clinical development;Clinical Protocols;Clinical Trials;clinically relevant;Collaborations;commercialization;Communicable Diseases;Cytomegalovirus Retinitis;Development;Devices;Dose;drug candidate;Drug Delivery Systems;drug development;Drug Kinetics;emtricitabine;Environment;Evaluation;experience;FDA approved;Female;first-in-human;Formulation;Funding;Future;Ganciclovir;genital herpes;Goals;Guidelines;helicase;Hematology;Human;Implant;improved;In Vitro;in vivo;Industry;Infection;inhibitor;innovation;interest;Investigational Drugs;Investigational New Drug Application;Laboratories;Lead;Local Therapy;manufacture;manufacturing capabilities;manufacturing process;Methods;New Drug Approvals;novel;novel therapeutics;Oral;Pain;patient population;Pharmaceutical Preparations;Pharmacologic Substance;Pharmacology and Toxicology;Phase;Phase II Clinical Trials;pre-exposure prophylaxis;preclinical development;preclinical trial;Primates;product development;Prophylactic treatment;Provider;Published Comment;Recurrence;research clinical testing;Research Personnel;Resources;Rodent;Safety;Sheep;Skin;Small Business Innovation Research Grant;stability testing;Synthesis Chemistry;Systemic Therapy;systemic toxicity;Technology;technology platform;Tenofovir;Testing;Therapeutic;Topical application;Toxic effect;Toxicogenetics;Toxicology;United States National Institutes of Health;vaginal fluid;Vaginal Ring;Viral;volunteer;Woman;Work

PROJECT_TITLE: IND-enabling Preclinical Development of a Sustained-release Pritelivir Intravaginal ring for the Treatment and Prophylaxis of Genital Herpes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DCAI-F(12)]


PI_NAMEs: LEE, DARREN JAMES (contact)

PROJECT_TERMS: cell type;Cells;Center Core Grants;Computer software;Data;Data Analyses;Development;disease model;Environment;Equipment;experimental analysis;Eye;Eye diseases;Flow Cytometry;Funding;Grant;Guidelines;Health Sciences;Hour;Human Resources;Image;Immunoassay;Immunobiology;Infection;Inflammation;innovation;instrumentation;Laboratories;Lasers;Modeling;Molecular;novel;Oklahoma;Pathogenesis;Publications;Reader;Research;Research Personnel;Sampling;Scientist;Services;skills;Suspensions;synthetic polymer Bioplex;System;Therapeutic;Training;Universities;user-friendly;Vision;vision development;Vision research


NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: SANTA BARBARA

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF CALIFORNIA SANTA BARBARA

PHR: NARRATIVE The conversion of a fertilized egg into a fully developed human comprised of many different cell is orchestrated by genes acting through complex networks. Despite genetic variations between different individuals, these networks generally lead to a faithfully formed human. We propose to reveal how such gene networks operate faithfully in individuals with varying genetic makeups and how non-genetic heritable (epigenetic) effects influence successful outcomes from these developmental gene networks. The findings from this research may lead to a better understanding of the events that lead to accurate embryo development and how genetic and epigenetic alterations can disrupt them, resulting in birth defects. They will also help to illuminate the relationship between an individual's genetics, their propensity for medical difficulties, and their responsiveness to drugs, thereby contributing to advances in precision medicine.

PI_NAMEs: ROTHMAN, JOEL H. (contact)

PROGRAM_OFFICER_NAME: WELLS, MELISSA LYNN

PROJECT_TERMS: Activator Appliances;Affect;Animals;Architecture;Body System;Caenorhabditis elegans;Candidate Disease Gene;causal variant;Cell division;Cells;Chromatin;Complex;Congenital Abnormality;Development;Developmental Gene;differential expression;Embryo;Embryonic Development;Endoderm;endodermal progenitor;Ensure;Epigenetic Process;epigenetic variation;Event;Excision;Gene Expression;gene network;gene regulatory network;Genes;Genetic;Genetic Transcription;genetic variant;Genetic Variation;Genome;genome-wide analysis;genomic locus;Genotype;Germ Layers;Goals;Heritability;Histones;Human;Individual;Lead;Malignant Neoplasms;MAP Kinase Gene;Maps;Medical;Methods;Methylation;Molecular;network architecture;next generation sequencing;non-genetic;Nuclear;Outcome;Output;Parents;Pathway interactions;Pharmaceutical Preparations;pharmacologic;Phenotype;Phosphotransferases;Physiological;piRNA;precision medicine;Process;Quantitative Trait Loci;Regulation;Regulator Genes;Research;Resolution;response;RNA;RNA Interference;Role;Signal Transduction;Small RNA;Sorting;Specific qualifier value;stem cells;System;TCF Transcription Factor;Testing;transcription factor;transgenerational epigenetic inheritance;Untranslated RNA;Variant;WNT Signaling Pathway;zygote

PROJECT_TITLE: Plasticity in an embryonic gene regulatory network

STUDY_SECTION_NAME: Development - 2 Study Section[DEV2]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cardiovascular;Gene Therapy;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Nanotechnology;Precision Medicine;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIV NEW YORK MORNINGSIDE

ORG_STATE: NY

PHR: PROJECT NARRATIVE  Heart disease is the leading cause of death in the United States. About 875,000 Americans die from heart disease each year, of which 50-60% deaths are caused by coronary artery disease which can further develop into heart failure and scarring. We discovered a specific non-coding RNA (lnc RNA TARID) in the exosomes that play an essential role in cardiac repair. In this grant proposal we will use lipid nanoparticles to deliver this non-coding RNA to the injured heart and study safety, efficacy, and mechanism in both small and large animal models.

PI_NAMEs: CHENG, KE  (contact)

PROGRAM_OFFICER_NAME: LUO, JAMES

PROJECT_TERMS: Acute;Address;adverse outcome;American;Animal Model;Animals;Applications Grants;Biocompatible Materials;Biodistribution;Biological;Biological Availability;Blood flow;Blood Platelets;Blood Vessels;cardiac repair;cardiac tissue engineering;Cardiomyopathies;Cardiovascular Models;Cause of Death;Cells;Chronic;Cicatrix;Clinical Trials;clinically relevant;Coronary Arteriosclerosis;coronary fibrosis;cytotoxicity;design;Development;Dimensions;Disease;exosome;experimental study;Family suidae;first-in-human;Formulation;Gene Expression;Goals;Grant;Heart;Heart Diseases;Heart failure;heart function;Heart Injuries;Human;improved;In Vitro;insight;Interdisciplinary Study;large scale production;lipid nanoparticle;Mechanics;MicroRNAs;mouse model;Myocardial;Myocardial Infarction;Myocardial Ischemia;Myocardial Reperfusion Injury;Myofibroblast;nanoparticle;new technology;nucleic acid delivery;Paper;particle;Pathway interactions;Patients;Pericardial cavity;Pharmaceutical Preparations;Play;porcine model;Precision therapeutics;preclinical study;Progress Reports;Publications;Quality Control;Reperfusion Injury;Research;RNA;Rodent Model;Role;Safety;safety study;Selection Criteria;stem cell delivery;Stem Cell Development;stem cell technology;stem cells;success;Sudden Death;Surface;Technology;Testing;Therapeutic;Therapeutic Effect;therapeutic RNA;Toxic effect;transcription factor;Translating;translational applications;United States;Untranslated RNA;Upstream Enhancer;Ventricular

PROJECT_TITLE: Developing Long Noncoding RNA Therapy for Precision Cardiac Repair

STUDY_SECTION: TDPS

STUDY_SECTION_NAME: Therapeutic Development and Preclinical Studies Study Section[TDPS]


ORG_NAME: VA  MEDICAL CENTER

PHR: Approximately 40% of Veterans have obesity and are at increased risk for cardiometabolic disease. Intensive lifestyle-based weight management programs can lead to clinically significant (≥5%) weight loss. The VA’s MOVE! program is effective for promoting weight loss and behavior change for those who attend. Unfortunately, MOVE! has low enrollment and high attrition due to several obstacles including low motivation. Mental Contrasting with Implementation Intentions (MCII) is an innovative strategy developed over 20 years of research that uses imagery to increase motivation for behavior change. MCII can be implemented in primary care settings using an easy to teach technique called “WOOP” (Wish, Outcome, Obstacle, Plan) that Veterans then use regularly on their own with the help of paper-based tools or the WOOP app. We will evaluate the efficacy and implementation of MCII when combined with telephone-delivered MOVE! vs. telephone-delivered MOVE! alone to enhance weight management outcomes for Veterans in primary care.

PI_NAMEs: JAY, MELANIE  (contact)

PROJECT_TERMS: acceptability and feasibility;Agreement;arm;Awareness;Behavior;behavior change;Body Weight Changes;Body Weight decreased;Cardiometabolic Disease;cardiometabolic risk;Chronic Disease;Clinic;clinically significant;Cognitive;cognitive process;cohort;Complex;Consumption;cost;Counseling;COVID-19 pandemic;Data;design;Diet;dietary;disorder prevention;Education;Educational process of instructing;effectiveness/implementation study;efficacy evaluation;efficacy testing;Eligibility Determination;Enrollment;evidence base;Evidence based intervention;exercise program;experience;food craving;fruits and vegetables;Funding;Future;future implementation;Goals;Guidelines;Health Promotion;Healthy Eating;Imagery;implementation barriers;implementation evaluation;implementation facilitation;improved;indexing;informant;innovation;Intake;Intention;Intervention;Interview;laboratory experiment;Learning;Life Style;Measures;member;Methodology;moderate-to-vigorous physical activity;Monitor;Motivation;motivational enhancement therapy;motivational processes;New York City;novel;Obesity;Outcome;outreach;Paper;Participant;participant interview;Patients;Persons;Physical activity;Pilot Projects;Policies;Primary Care;primary care practice;primary care provider;primary care setting;primary outcome;Procedures;Process;programs;Provider;Psyche structure;psychologic;Randomized;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;Reporting;Research;Risk;Schizophrenia;screening;Site;Social support;Specific qualifier value;Standardization;Stress;stroke survivor;Structure;Techniques;Telephone;telephone delivery;Testing;Time;tool;Training;Travel;Veterans;Visit;waist circumference;web site;Weight;Weight maintenance regimen;women patients;Work

PROJECT_TITLE: WOOP VA: Mental Contrasting With Implementation Intentions to Promote Weight Management in Primary Care

STUDY_SECTION_NAME: HSR-2 Behavioral, Social, and Cultural Determinants of Health and Care[HSR2]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Prevention;Women's Health Research

ORG_CITY: Aurora

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative Dr. Abuogi has extensive experience conducting interdisciplinary implementation science research that addresses key knowledge and outcome gaps for women, adolescents and children living with HIV. Dr. Abuogi has a demonstrated commitment to training new investigators and a track record of mentorship success and productivity. This award provides her with protected time to expand her mentoring and research activities related to improving HIV and health outcomes for vulnerable populations living with HIV in high burden settings.

PI_NAMEs: ABUOGI, LISA LYNN (contact)

PROGRAM_OFFICER_NAME: MCKAIG, ROSEMARY G

PROJECT_TERMS: Address;Adherence;Adolescent;Adolescent and Young Adult;adolescent woman;Adult;AIDS prevention;antenatal care;antiretroviral therapy;Award;Behavior Therapy;Behavioral Sciences;care outcomes;career;Caring;Child;Clinic;Collaborations;Colorado;Counseling;Dedications;Disparity;Electronics;empowerment;Enrollment;Ensure;evidence base;experience;Extramural Activities;Failure;Focus Groups;Funding;global health;Goals;Health;health disparity;HIV;Impact evaluation;implementation science;improved;Infrastructure;innovation;Intervention;Intervention Studies;Interview;Kenya;Knowledge;Mentors;Mentorship;mid-career faculty;Midcareer Investigator Award in Patient-Oriented Research;Modeling;multidisciplinary;next generation;NIH Office of AIDS Research;Outcome;Parents;Participant;patient oriented research;Patients;Pediatric Hospitals;Pediatrics;peer;peer support;Perception;Persons;Physician Executives;Physicians;Population;Postpartum Period;Postpartum Women;pregnant;Pregnant Women;prevent;Prevention program;primary outcome;Productivity;Provider;Psychosocial Assessment and Care;Qualifying;Randomized;Readiness;recruit;Research;Research Activity;Research Personnel;Research Priority;resilience;Resource-limited setting;Sampling;Science;Scientist;Site;skills;standard of care;Structure;success;Time;Training;Treatment Failure;Treatment outcome;treatment risk;United States National Institutes of Health;Universities;uptake;Viral;Visit;Vulnerable Populations;Woman;Work;young adult;Youth

PROJECT_TITLE: Achieving successful treatment outcomes among adolescents and pregnant/postpartum women living with HIV in Kenya

STUDY_SECTION: AIDS

STUDY_SECTION_NAME: Acquired Immunodeficiency Syndrome Research Study Section[AIDS]


ED_INST_TYPE: SCHOOLS OF EDUCATION

NIH_SPENDING_CATS: Aging;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Nutrition;Prevention;Sarcopenia

ORG_NAME: NEW YORK UNIVERSITY

PHR: PROJECT NARRATIVE: The swallowing muscles are prone to decreased strength and function as part of the natural aging process which can lead to difficulty swallowing, malnutrition, and frailty. Exercise and nutrition are powerful stimulators of muscular change. The proposed research will investigate the effectiveness of a proactive regimen of swallowing exercises (with or without daily protein supplement drinks) to improve the composition, force, and physiology of the swallowing muscles and explore the relationship to overall health and physical function in community-dwelling older adults.

PI_NAMEs: MOLFENTER, SONJA M (contact)

PROJECT_TERMS: Address;Age;age related;age related decline;age-related muscle loss;Aging;aging process;Aspiration Pneumonia;Biochemical Markers;Biomechanics;Biometry;Blood specimen;Body Composition;care outcomes;Clinical;Communities;comorbidity;constriction;Consumption;Data;Deglutition;Deglutition Disorders;Dehydration;demographics;design;Dose;effective intervention;Effectiveness;Empirical Research;Exercise;exercise regimen;experience;Fatty acid glycerol esters;Food;Frail Elderly;frailty;Frequencies;Funding;Goals;Hand Strength;Health;healthy aging;Human;Image;Impairment;improved;Individual;Inferior;instrumentation;Intervention;Investigation;Limb structure;Liquid substance;Literature;Magnetic Resonance Imaging;Malnutrition;Manometry;Measures;Mechanics;Mental Depression;Methods;multidisciplinary;Muscle;muscle form;Muscle function;muscle physiology;muscle strength;Muscular Atrophy;normal aging;nursing skill;nutrition;Nutritional status;older adult;Outcome;Outcome Measure;Participant;Patients;Periodicity;Persons;Pharyngeal structure;pharynx muscle;Phase;Physical Function;Physical Performance;Physiological;Physiology;Pneumonia;Population;Positioning Attribute;Prealbumin;Prediction of Response to Therapy;prevent;Process;Proteins;Protocols documentation;Quality of life;Radiology Specialty;Randomized;Regimen;Research;Research Design;Resistance;Resolution;Risk;Role;sarcopenia;Science;sex;Social isolation;study population;success;Supplementation;Testing;United States National Institutes of Health

PROJECT_TITLE: Proactive pharyngeal swallowing exercises: Building muscular reserve in pre-frail older adults

STUDY_SECTION: MFSR

STUDY_SECTION_NAME: Motor Function, Speech and Rehabilitation Study Section[MFSR]


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Drug Abuse (NIDA only);Mental Health;Neurosciences;Substance Misuse

PHR: PROJECT NARRATIVE This grant will support training of a new generation of graduate and undergraduate students in computational neuroscience. Computational neuroscience contributes to fundamental knowledge about brain function and behavior and to more precise characterization of brain disorders.

PI_NAMEs: MA, WEI JI  (contact)

PROGRAM_OFFICER_NAME: MOLLICK, JESSICA ANN

PROJECT_TERMS: academic preparation;Behavior;Brain;career;Cognition;Collaborations;college;Communities;Compensation;computational neuroscience;Development;doctoral student;Educational Curriculum;Educational workshop;Exposure to;Faculty;Funding;Goals;Infrastructure;Journals;Laboratory Research;Mathematics;Measures;Mentors;neural;Neurosciences;New York;Perception;pre-doctoral;Productivity;programs;Psychology;Research;Role;Rotation;Running;Science;skills;Students;Traineeship;Training;Training Programs;undergraduate student;United States National Institutes of Health;Universities;Writing

PROJECT_TITLE: Training program in computational approaches to brain and behavior


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

ORG_CITY: SEATTLE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE / RELEVANCE This overall goal of this Training Program is to provide critical support and training to prepare the next generation of cancer prevention researchers, committed to reducing the burden of cancer by addressing factors that contribute to cancer health disparities. The training focuses on cancer epidemiology and social determinants of health in relation to health disparities through didactic instruction, career development support, and the conduct of high-quality research with a skilled team of mentors.

PI_NAMEs: LI, CHRISTOPHER I;PHIPPS, AMANDA IRENE (contact)

PROGRAM_OFFICER_NAME: BOULANGER-ESPEUT, CORINNE A

PROJECT_TERMS: cancer health disparity

PROJECT_TITLE: Contributing Factors and Consequences of Cancer Health Disparities

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


ORG_CITY: SYRACUSE

ORG_NAME: UPSTATE MEDICAL UNIVERSITY

PHR: Project Narrative The selective routing of retinal ganglion cell (RGC) axons to the correct side of the brain by the cells of the optic chiasm is required for normal vision. Here we investigate how β2 laminins, an essential component of the extracellular matrix sheet surrounding the brain, controls the organization of the cells in the optic chiasm and thereby the selective routing of RGC axons. The findings from this project will lead to new insights into the regulation of selective axon routing and the development of rational strategies for RGC axon regeneration and brain target selection.

PI_NAMEs: MARTÍNEZ-DE LUNA, REYNA I (contact)

PROGRAM_OFFICER_NAME: CLAYTON, EDWIN C

PROJECT_TERMS: Address;ADGR1 gene;Adhesions;Anatomy;Antibodies;Axon;axon growth;axon guidance;axon regeneration;Basement membrane;Brain;brain cell;Brain region;Cell Polarity;Cells;Cellular Morphology;Complex;Coupled;Cues;Data;Depth Perception;Development;Dominant-Negative Mutation;Dystroglycan;experimental study;Extracellular Matrix;Future;Goals;Growth;In Vitro;in vivo;information organization;innovation;insight;Integrins;Ipsilateral;Knowledge;Label;Laminin;Laminin Receptor;Mediating;Membrane;Methods;Microscopy;Modeling;Molecular;Morphology;Mus;Neuroglia;Neurons;Optic Chiasm;Optic tract structure;PARD6A gene;Pattern;Phase;Proliferating;Proteins;Radial;receptor;Regulation;Resolution;retinal axon;retinal ganglion cell regeneration;Retinal Ganglion Cells;Role;Route;segregation;Side;Signal Transduction;Spatial Distribution;spatiotemporal;Surface;Techniques;Testing;Thinness;Time;Tissues;transmission process;Vascular Endothelial Growth Factors;Vision;Visual System;Work

PROJECT_TITLE: The role of extracellular matrix in axon routing

STUDY_SECTION: BDE

STUDY_SECTION_NAME: Biology and Development of the Eye Study Section[BDE]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Data Science;Networking and Information Technology R&D (NITRD)

PHR: PROJECT NARRATIVE This proposal addresses the critical need for robust computational methods and tools for mass spectrometry (MS)-based proteomics data. We are focusing on three key areas of biological research: MS-based characterization of “interactomes”, post-translational modifications (PTMs), and single-cell proteomics. We will develop new functionalities and algorithms in our interactome analysis resources, advance comprehensive PTM profiling strategies, and improve the sensitivity and accuracy of protein quantification in single-cell data. We will continue providing our widely used computational tools and data resources to the research community.

PI_NAMEs: NESVIZHSKII, ALEXEY I (contact)

PROJECT_TERMS: Address;ADP ribosylation;Affinity Chromatography;Algorithms;analysis pipeline;Area;Awareness;base;Benchmarking;Biological;biological research;Cell Physiology;Cells;Chemicals;Chemistry;chemoproteomics;Collection;Communities;Complex;Computational algorithm;computational platform;computerized tools;Computing Methodologies;computing resources;Data;data mining;data modeling;data resource;deep learning;Detection;Development;Dimensions;Disease;Evaluation;Genomics;Grant;Health;Heterogeneity;improved;indexing;innovation;insight;ion mobility;Isotope Labeling;Joints;Label;Maps;Mass Spectrum Analysis;Measures;Modeling;novel;novel strategies;Peptides;Play;Post Translational Modification Analysis;Post-Translational Protein Processing;Preparation;Protein Analysis;protein protein interaction;Proteins;Proteomics;Protocols documentation;Publishing;repository;Research;Resources;Running;Sampling;Scientist;Site;Speed;Statistical Data Interpretation;Statistical sensitivity;success;Technology;time of flight mass spectrometry;tool;tool development;transcriptomics;treatment response;Work

PROJECT_TITLE: COMPUTATIONAL TOOLS FOR MASS SPECTROMETRY-BASED INTERACTOME DATA

STUDY_SECTION: BDMA

STUDY_SECTION_NAME: Biodata Management and Analysis Study Section[BDMA]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lewy Body Dementia;Neurodegenerative;Neurosciences;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: Boston

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: TUFTS UNIVERSITY MEDFORD

PHR: Project Narrative Our study will use a multi-disciplinary approach to provide critical, new information about the impacts of airborne fine particle and metal exposures on dementia-associated neuropathology (DAN) and incident dementia (including Alzheimer’s Disease (AD), microvascular brain injury (μVBI), and Lewy body disease (LBD)), and the pathways through which they do so. Results from our study will further our understanding of whether and how airborne metals contribute to DAN and dementia.

PI_NAMEs: SONNEN, JOSHUA A;SUH, HELEN  (contact)

PROGRAM_OFFICER_NAME: GRAY, KIMBERLY A

PROJECT_TERMS: Adult;Aging;aging brain;Air Pollutants;Air Pollution;Alzheimer's Disease;ambient air pollution;Anatomy;Apolipoprotein E;Autopsy;Behavior;Behavioral;Biometry;Brain;brain health;Brain region;brain tissue;Cerebellum;Cerebrovascular Disorders;Cerebrovascular Trauma;Cessation of life;Clinical;clinical database;Cognition;Cognitive;cognitive ability;cognitive function;cognitive performance;cohort;Collaborations;Consensus;Consent;Coupled;Data;Dementia;dementia burden;Diagnosis;Discipline;Disease;DSM-IV;Enrollment;Epidemiology;epidemiology study;Ethnic Origin;Evaluation;Exposure to;fine particles;follow-up;Gender;Genotype;glial activation;Gliosis;Health;Health Care Costs;health data;Human;Impaired cognition;instrument;interdisciplinary approach;Intervention;Knowledge;Lewy Bodies;Lewy Body Disease;Life Style;Mass Spectrum Analysis;Measures;Mediating;Mediation;Metal exposure;Metals;mixed dementia;Modeling;modifiable risk;Modification;Morbidity - disease rate;mortality;Nerve Degeneration;neuropathology;novel;older adult;older men;older women;olfactory bulb;Olfactory Pathways;Olfactory tract;Outcome;Participant;particle;particle exposure;Pathologic;Pathology;Pathway Analysis;Pathway interactions;Pharmaceutical Preparations;physical conditioning;Plasma;pollutant;Population;prospective;Prospective, cohort study;Psychometrics;Race;Recording of previous events;Research;Resources;Risk;Risk Factors;Sampling;Scanning Electron Microscopy;Science;screening;sex;socioeconomics;spatiotemporal;systemic inflammatory response;Testing;Toxicology;United States;Vascular Diseases;Visit

PROJECT_TITLE: Airborne metals, neurodegeneration, and dementia in the Adult Changes in Thought study

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Emergency Care;Eye Disease and Disorders of Vision;Health Services;Neurosciences

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it is expected to improve the ability of non-specialty urgent and emergent care providers to provide patients with eye examinations on site. Leveraging innovative imaging technologies developed by our laboratories and modified specifically to be used without on site personnel, we expect to make modern ocular imaging techniques more readily available where the patients are. This provides the potential to improve eye diagnostics at the point of care in a physically distanced manner.

PI_NAMEs: KUO, ANTHONY NANLIN (contact)

PROGRAM_OFFICER_NAME: LEE, PAEK-GYU

PROJECT_TERMS: Accident and Emergency department;Affect;Anterior;Atrophic;Biomedical Engineering;care delivery;care providers;Caring;Chronic;Clinic;Clinical;clinical examination;Color;cost;COVID-19 pandemic;Data;design;Development;Diagnostic;diagnostic value;Elements;Emergency Department Physician;Emergency Medicine;Emergency Situation;Emergent care;Environment;Eye;fluorescence imaging;Future;Geographic Distribution;Head;Hemorrhage;Human Resources;Image;Image Analysis;imaging capabilities;imaging Segmentation;imaging system;Imaging Techniques;Imaging technology;improved;Infection Control;innovation;instrument;Iritis;Laboratories;Lasers;Lesion;Medical;medical specialties;Modality;Modernization;Motion;multidisciplinary;ocular imaging;operation;ophthalmic examination;Ophthalmologist;Ophthalmoscopes;Optical Coherence Tomography;Optics;pandemic disease;Participant;Pathology;Patient imaging;Patients;Photography;Physicians;point of care;Provider;Public Health;Pupil;Quality of Care;remote monitoring;Reporting;Research;Research Proposals;response;Rest;Retina;retinal imaging;Robot;Robotics;Scanning;screening;Site;Social Distance;Specialist;standard of care;Standardization;success;System;Techniques;Testing;Time;Training;urgent care;Visit;Width

PROJECT_TITLE: Self-aligning, motion-stabilized ocular imaging for eye care in urgent and emergent care settings

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-NV-P(81)S]


ORG_CITY: MEMPHIS

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

ORG_STATE: TN

PHR: PUBLIC HEALTH RELEVANCE - This application would support continued postdoctoral training to young epidemiologists, behavioral scientists, geneticists and clinician-researchers who will become the next generation of scientists in pediatric cancer survivorship research. The training focuses on pediatric cancer survivorship and cancer control outcomes with research approaches informed by Global Health issues. Progress in these areas could have a major impact in reducing the burden of cancer and improving quality of life in cancer survivors.

PI_NAMEs: KRULL, KEVIN R (contact)

PROJECT_TERMS: Cancer Survivorship;Intervention;Malignant Childhood Neoplasm;Outcome;Training

PROJECT_TITLE: Training in Pediatric Cancer Survivorship Outcomes and Interventions


NIH_SPENDING_CATS: Cancer;Clinical Research;Digestive Diseases;Genetics;Orphan Drug;Pancreatic Cancer;Precision Medicine;Prevention;Rare Diseases

ORG_CITY: BOSTON

ORG_NAME: DANA-FARBER CANCER INST

PHR: PROJECT NARRATIVE Localized pancreatic cancers (PC) have a high risk of recurrence and are treated with neoadjuvant chemotherapy which improves cure rates though identifying early resistance during NAC remains a clinical challenge. This project utilizes advances in single cell transcriptomics, highly multiplexed imaging and ctDNA technologies, paired with large clinically annotated PC biospecimen repositories to develop methods for assessing response and identifying resistance to neoadjuvant therapies used in localized PC. I anticipate that this work will nominate novel biomarkers for clinical use.

PI_NAMEs: SINGH, HARSHABAD  (contact)

PROGRAM_OFFICER_NAME: RADAEV, SERGEY

PROJECT_TERMS: Adjuvant Chemotherapy;Admixture;Adoption;Award;Basal Cell;biobank;Biological Assay;Biological Specimen Banks;biomarker selection;Biopsy;Blood;CA-19-9 Antigen;Cancer Biology;cancer diagnosis;career;CDKN2A gene;Cell Fraction;Cells;Chemoresistance;chemotherapy;Chemotherapy-Oncologic Procedure;Clinical;Clinical Trials;cohort;Dana-Farber Cancer Institute;Development;Diagnosis;Diagnostic;digital;Disease;Early identification;Enhancers;Epigenetic Process;Evolution;Excision;Exhibits;experience;Exposure to;Fluorouracil;gemcitabine;Gene Expression;Gene Mutation;Genes;Genetic;Genetic Transcription;Goals;Heterogeneity;high risk;Histones;imaging modality;Immunofluorescence Immunologic;improved;Incidence;Individual;ineffective therapies;Institution;International;irinotecan;KRAS2 gene;Laboratories;Lead;MADH4 gene;Malignant neoplasm of pancreas;Measures;Mentors;Methods;Molecular;mortality;multiplexed imaging;Mutation;nano-string;Neoadjuvant Therapy;neoplastic cell;novel;novel marker;Operative Surgical Procedures;Outcome;outcome prediction;oxaliplatin;Paclitaxel;Pancreas;pancreatic cancer patients;pancreatic neoplasm;Pathologic;Patient Monitoring;Patient-Focused Outcomes;Patients;Pattern;Phenotype;Physicians;Postoperative Period;predicting response;Prediction of Response to Therapy;predictive marker;Prior Chemotherapy;prognostic;programs;protein biomarkers;radiological imaging;Recurrence;Regimen;Research;Resistance;Resistance profile;Resources;response;response biomarker;Risk;Screening for cancer;Selection for Treatments;Sensitivity and Specificity;single cell analysis;Specificity;Specimen;Technology;therapy resistant;Time;TP53 gene;Training Programs;transcriptome;transcriptomics;treatment response;trend;triple-negative invasive breast carcinoma;tumor;Tumor Burden;tumor diagnostic;tumor DNA;Tumor Markers;Tumor Tissue;Work

PROJECT_TITLE: Improving response prediction to neoadjuvant therapy in pancreatic cancer

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


NIH_SPENDING_CATS: Cancer

ORG_CITY: SAINT LOUIS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Narrative Cancer is a major public health and economic issue and its burden is set to spiral. In 2022, roughly 1.9 million people will be diagnosed with cancer in the United States. The goal of this grant is to train a new generation of scientists who will make discoveries that enable us to diagnose, treat, and perhaps cure these diseases.

PI_NAMEs: RATNER, LEE  (contact)

PROGRAM_OFFICER_NAME: LIM, SUSAN E

PROJECT_TERMS: Grant;molecular oncology;Training

PROJECT_TITLE: Molecular Oncology Training Grant


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Prevention

PHR: Project Narrative Alzheimer disease (AD) is a neurodegenerative condition that exhibits a marked age- dependence. Levels of NAD+ decline in animals and humans as a function of age, and restoring NAD+ levels has been shown to slow or prevent deficits seen in pre-clinical models of AD. Here, we describe a comprehensive program to develop a brain penetrant, small molecule that potently stimulates the rate-limiting enzyme regulating NAD+ levels in the brain, as a treatment for late onset AD patients.

PI_NAMEs: CHEN, BEIBEI  (contact);RIZZO, STACEY J

PROGRAM_OFFICER_NAME: REFOLO, LORENZO

PROJECT_TERMS: Acceleration;Age;age related;age related decline;Aging;aging brain;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease patient;Animal Model;Animals;Binding;Biological Assay;Biological Markers;blood-based biomarker;Brain;Cells;Chemicals;Chemistry;Chronology;Clinical;clinical candidate;Clinical Trials;cognitive function;Data;Data Set;Dependence;Development Plans;Disease;Dose;drug development;drug discovery;Enzymes;Exhibits;experience;Future;Goals;Human;human subject;Impaired cognition;improved;in vivo;Induced pluripotent stem cell derived human neuron;innovation;Late Onset Alzheimer Disease;Lead;lead optimization;Legal patent;Libraries;Ligand Binding;manufacture;manufacturing scale-up;Metabolism;mild cognitive impairment;Modeling;mouse model;Mus;Nerve Degeneration;Neurons;nicotinamide phosphoribosyltransferase;novel;Nutraceutical;Pathway interactions;Patients;pharmacologic;phase 1 testing;Phase I Clinical Trials;Population;pre-clinical;Pre-Clinical Model;preclinical efficacy;Preclinical Testing;prevent;programs;Qualifying;Research Personnel;Risk Factors;Route;scale up;screening;Series;Serum;small molecule;Sodium Chloride;targeted biomarker;Technology;Testing;Therapeutic Index;Tissues;Toxicology;uptake;Validation

PROJECT_TITLE: Developing a NAMPT activator for Alzheimer’s disease