NIH_SPENDING_CATS: Biotechnology;Cancer;Orphan Drug;Ovarian Cancer;Precision Medicine;Rare Diseases;Women's Health Research

ORG_CITY: SAN ANTONIO

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

PHR: Project Narrative Ovarian cancer (OCa) is the deadliest of all gynecologic cancers, and new therapeutic strategies are desperately needed to improve OCa patient survival. We identified a small chemical molecule ERX-208, that promote endoplasmic reticulum (ER) stress in OCa cells but not in normal cells and has potent anti-proliferative activity. Proposed studies will enable both a better molecular understanding of how ERX-208 induces ER stress in OCa cells and enable rational design of more potent versions of ERX-208 either alone in combination with current chemotherapies. We believe that this project will generate a novel therapeutic agent and the preclinical rationale for further clinical translation.

PI_NAMEs: AHN, JUNG-MO ;VADLAMUDI, RATNA K (contact)

PROGRAM_OFFICER_NAME: VENKATACHALAM, SUNDARESAN

PROJECT_TERMS: Acid Lipase;analog;Apoptosis;ATF6 gene;Binding;Biodistribution;Biological;cancer cell;Cancer cell line;Cancer Etiology;Cancer Model;Cancer Patient;Cell Death;Cell Line;Chemicals;Chemistry;chemotherapy;Clinical;clinical translation;Clinical Trials;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;cofactor;Disease;Dose;Drug Kinetics;efficacy testing;EIF-2alpha;endoplasmic reticulum stress;Epithelial Cells;exhaust;Face;Growth;GRP78 gene;Heterogeneity;Homeostasis;improved;In Vitro;in vivo;indexing;Induction of Apoptosis;Inter-tumoral heterogeneity;knock-down;lead optimization;Libraries;Lipase;Malignant Female Reproductive System Neoplasm;Malignant neoplasm of ovary;Maximum Tolerated Dose;misfolded protein;Modeling;Molecular;molecular subtypes;mouse model;Mutagenesis;neoplastic cell;new therapeutic target;Normal Cell;Normal tissue morphology;novel therapeutic intervention;novel therapeutics;Organoids;Outcome;overexpression;Pathway interactions;patient derived xenograft model;Patients;Pharmaceutical Chemistry;Pharmaceutical Preparations;Pharmacodynamics;pharmacologic;potential biomarker;pre-clinical;Prognosis;Protein Biosynthesis;Proteins;Proteomics;rational design;reconstitution;Resistance;response;response biomarker;Signal Pathway;Somatic Mutation;Specificity;survival outcome;System;Testing;Therapeutic;Therapeutic Agents;Toxic effect;transcriptomics;translational study;Treatment Efficacy;tumor;tumor heterogeneity;tumor progression;United States;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Enhancing endoplasmic reticulum stress in ovarian cancer

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 2 Study Section[MCT2]


ADMINISTERING_IC: DK

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Digestive Diseases;Neurosciences;Nutrition;Physical Injury - Accidents and Adverse Effects;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_CITY: HERSHEY

ORG_COUNTRY: UNITED STATES

ORG_DEPT: NEUROSCIENCES

ORG_FIPS: US

ORG_NAME: PENNSYLVANIA STATE UNIV HERSHEY MED CTR

ORG_STATE: PA

PHR: Project Narrative Proper coordination of gastric reflexes is dependent on vagal afferent responses to mechanical and chemical stimuli, including the orexigenic gut peptide ghrelin. The goal of the current project is to examine whether ghrelin-mediated inhibition of voltage-gated Ca2+ channels is dysregulated in gastric-projecting vagal afferent neurons following experimental spinal cord injury (SCI). The results of this study will offer insight into mechanisms underlying gastrointestinal dysfunction following SCI and could improve therapeutic targets of gastric motility disorders.

PI_NAMEs: GOUDSWARD, HANNAH J (contact)

PROGRAM_OFFICER_NAME: DENSMORE, CHRISTINE L

PROJECT_TERMS: Acute;Address;afferent nerve;Afferent Neurons;Animal Model;Appetite Stimulants;Attenuated;Binding;Biological Models;Calcium;Calcium Channel;Cells;Chemicals;Chest;Cholecystokinin;Chronic;Clinical;Closure by clamp;comorbidity;Coupled;Couples;Cutaneous;Diabetes Mellitus;Disease;Electrophysiology (science);experimental study;Fiber;Functional disorder;Future;G-Protein-Coupled Receptors;gastrointestinal;Gastrointestinal Hormones;Gastroparesis;Genetic Transcription;ghrelin;Goals;growth hormone secretagogue receptor;Health;Heterotrimeric GTP-Binding Proteins;Hormones;Imaging Techniques;Immunohistochemistry;Impairment;improved;In Vitro;in vivo;Individual;Injury;innovation;insight;Knowledge;Ligands;Mechanics;Mediating;mimetics;Modeling;Molecular;Motility;motility disorder;Motor;Motor output;Nerve;neuronal cell body;neuronal excitability;Neurons;neurotransmitter release;Nodose Ganglion;Obesity;Outcome;patch clamp;Pathway interactions;Peptides;Peripheral;Polymerase Chain Reaction;pre-clinical;Presynaptic Terminals;Quality of life;Rattus;receptor;Receptor Activation;Reflex action;Reporting;response;Reverse Transcription;Role;Scientist;Sensory;Signal Pathway;Signal Transduction;social;Spinal cord injury;Spinal cord injury patients;Stimulus;Stomach;Structure;Synapses;Techniques;Testing;therapeutic target;Training;transmission process;Vagus nerve structure;voltage;Work

PROJECT_TITLE: Ghrelin Modulation of CaV 2.2 Channels After Spinal Cord Injury


ADMINISTERING_IC: DC

ED_INST_TYPE: UNIVERSITY-WIDE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Pediatric

ORG_CITY: TUCSON

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: The purpose of this project is to understand the relation between language and higher-order cognition (i.e., planning, problem solving, and executive function) in young children with developmental language disorder (DLD), who have problems with both skills. One possibility is that children’s impaired language leads to impaired self-directed speech (i.e., nonsocial speech directed toward oneself to regulate thoughts and behavior), which is positively related to higher-order cognition in children with typical language. Documenting the development of self-directed speech in children with DLD and establishing how the use of self-directed speech affects planning performance among these children is important for our understanding of the nature of deficits in DLD and for informing possible treatment approaches for improving cognitive performance in this population.

PI_NAMEs: KAPA, LEAH LYNN (contact)

PROGRAM_OFFICER_NAME: STORKEL, HOLLY LYNN

PROJECT_TERMS: Address;Adult;Affect;Area;Articulation;Behavior;career;Caregivers;Child;Clinical;Cognition;Cognitive deficits;cognitive performance;cognitive skill;cognitive task;cognitive testing;Communication;Data;Development;executive function;Goals;Hand;Impairment;improved;Instruction;Language;Language Development Disorders;Language Disorders;language impairment;Linguistics;Mediating;Modeling;Nature;Nursery Schools;Participant;peer;Performance;Play;Population;prevent;Problem Solving;Production;Research;Role;School-Age Population;Self Direction;skills;social;social culture;Speech;Speech Development;stem;success;Task Performances;Testing;Thinking;Time;Training;verbal

PROJECT_TITLE: Development of Self-Directed Speech and Planning among Preschoolers with Developmental Language Disorder

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Breastfeeding, Lactation and Breast Milk;Clinical Research;Clinical Trials and Supportive Activities;Dietary Supplements;HIV/AIDS;Immunization;Microbiome;Nutrition;Pediatric;Pediatric - AIDS;Prevention;Vaccine Related

ORG_CITY: SEATTLE

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

ORG_STATE: WA

PHR: PROJECT NARRATIVE Infants born to mothers with HIV are more vulnerable to disease, have stunted growth, and have altered immunity, even when they are not infected with HIV themselves, which may be due to altered gut microbiome. Here, we propose to conduct a randomized, placebo-controlled, double-blind trial in infants exposed to HIV to test whether Bifidobacterium infantis EVC001 supplementation during the first month of life improves gut health, systemic inflammation and immunity longitudinally. This study may provide important preliminary evidence of a readily available intervention to improve gut health and subsequent immunity in infants exposed to HIV, a growing and vulnerable pediatric population.

PI_NAMEs: JASPAN, HEATHER BERYL (contact)

PROGRAM_OFFICER_NAME: MAJJI, SAI PRASANNA

PROJECT_TERMS: Address;Africa South of the Sahara;African;Age;Antibiotic Prophylaxis;arm;Bacille Calmette-Guerin vaccination;Bacteria;bacterial community;BCG Live;BCG Vaccine;Bifidobacterium;Biological Assay;Birth;Blood Cells;Breast Feeding;Breastfed infant;CD4 Positive T Lymphocytes;Cells;Cellular Immunity;Childhood;Clinical Management;cohort;Collecting Cell;commensal bacteria;Country;Data;Development;Disease;double-blind placebo controlled trial;Enrollment;Enzyme-Linked Immunosorbent Assay;Exhibits;Exposure to;Feces;feeding;Flow Cytometry;gastrointestinal epithelium;Gastrointestinal tract structure;Germ-Free;Growth;gut health;gut microbiome;gut microbiota;Gut Mucosa;Health;HIV;Human Microbiome;Human Milk;Immune;immune activation;Immune response;Immune system;Immunity;immunodeficiency;improved;infancy;Infant;Infant Health;infant outcome;Inflammation;Inflammatory;Intervention;intestinal fatty acid binding protein;LCN2 gene;Length;Life;Link;lipopolysaccharide-binding protein;maternal microbiota;Measurement;Measures;Memory;metabolome;metabolomics;Metagenomics;microbial;microbial composition;microbiome;microbiome composition;microbiome therapeutics;microbiota;Modeling;Mothers;Mucous Membrane;Mus;Nature;Neonatal;Oligosaccharides;Organism;Outcome;peripheral blood;Phenotype;Placebos;Play;Population;post intervention;prevent;prototype;Randomized;Regulatory T-Lymphocyte;response;Role;Safety;Sampling;Secondary to;self assembly;Shapes;Shotguns;South Africa;South African;Structure;Supplementation;systemic inflammatory response;Systems Development;T cell differentiation;T cell response;T-Lymphocyte;T-Lymphocyte Subsets;Testing;Therapeutic;Time;transmission process;Vaccination;vaccination outcome;vaccine response;Vaccines;vaginal microbiome;Vulnerable Populations;Whole Blood;Woman

PROJECT_TITLE: Bifidobacterium infantis supplementation in early life to improve immunity in infants exposed to HIV: a randomized, placebo-controlled, double-blind trial

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Pediatric;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_CITY: MEMPHIS

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

ORG_STATE: TN

PHR: RELEVANCE Influenza is a major public health threat worldwide, however, vaccine effectiveness is suboptimal and our current vaccine is strain specific, limiting effective control across multiple strains. This U01 addresses the critical need to improve understanding of how the human B and T cell response is established after initial influenza virus infection or vaccination in infants and children and to identify correlates of protection from disease. To this end, our consortium of world-renowned investigators is applying state-of-the-art immunological methods in the context of unique and established cohort studies in infants and children.

PI_NAMEs: GORDON, AUBREE L;THOMAS, PAUL G. (contact)

PROGRAM_OFFICER_NAME: ARNOLD, MICHELLE MARIE

PROJECT_TERMS: Address;Affect;anti-influenza;Antibodies;Antibody Response;Antigens;B-Lymphocytes;Biological Assay;Birth;Blood Banks;Blood specimen;CD8-Positive T-Lymphocytes;CD8B1 gene;Cells;Cellular Assay;Child;Childhood;Chronology;Clinical;cohort;Cohort Studies;Collaborations;demographics;design;Development;Disease;Disparate;Dissection;Elderly;Enrollment;Ensure;Epigenetic Process;experience;Exposure to;flu transmission;Head;Hemagglutinin;Human;Immune;Immune response;Immune system;Immunity;Immunologic Memory;Immunologics;imprint;improved;Individual;Infant;Infection;Influenza;influenza infection;Influenza vaccination;influenza virus vaccine;influenzavirus;innovation;insight;Investigation;Joints;Life;Longevity;Longitudinal cohort;Los Angeles;Mediating;member;Memory;Methods;Neuraminidase;New Zealand;Newborn Infant;Nicaragua;Nicaraguan;novel;novel vaccines;Post-Translational Protein Processing;Predisposition;Productivity;programs;Public Health;Publications;receptor;Recording of previous events;Recovery;recruit;Research;Research Personnel;response;Sampling;Seasons;Serology;Site;Specificity;T cell response;T-Cell Immunologic Specificity;T-Lymphocyte;Testing;unvaccinated;Vaccinated;Vaccination;vaccine effectiveness;vaccine strategy;vaccine-induced antibodies;Vaccines;Virus

PROJECT_TITLE: DIVINCI: Dissection of Influenza Vaccination and Infection for Childhood Immunity


ADMINISTERING_IC: HL

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Palliative Care

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: Narrative This T32 program is designed to train post-doctoral trainees in palliative care research concerning patients with heart, lung, or blood diseases. The program stresses the conduct of clinically-relevant, patient-oriented research in an ethical and scientifically rigorous manner and has an on-going commitment to attract and train individuals from under-represented minorities. In this renewal application, we propose to build on our successful program with innovative strategies to maximize the impact and sustainability of palliative care research and to help address compelling questions identified in the 2016 NHLBI Strategic Vision.

PI_NAMEs: KROSS, ERIN KATHRYN (contact);SHARMA, RASHMI K.

PROGRAM_OFFICER_NAME: KALANTARI, ROYA

PROJECT_TERMS: Grant;Palliative Care;Research Training

PROJECT_TITLE: Palliative Care Research Training Grant

STUDY_SECTION: NITM

STUDY_SECTION_NAME: NHLBI Institutional Training Mechanism Study Section[NITM(OA)]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: ALBUQUERQUE

ORG_NAME: ALBUQUERQUE VA MEDICAL CENTER

ORG_STATE: NM

PHR: Narrative Chemotherapy treatment often includes platinum based therapies such as oxaliplatin that produce peripheral nerve pain. Chemotherapy-induced pain is a burden imposed on patients (58-89%) causing sensitivity to touching cold items, discomfort swallowing cold items, throat discomfort, and muscle cramps. Symptoms are twice as severe in second and sequential treatment rounds with 79% of patients reporting moderate to severe pain scores. These symptoms can be permanent and disabling in > 40% of cancer survivors, substantially affecting quality of life. We have designed and engineered small antibody biologics referred to as scFvs. The scFvs target a nervous system receptor, called P2X4, that increases in pathological states such as chronic pain and anxiety conditions. In the proposed studies we (1) humanize the P2X4 scFv toward human use without initiating an immune response, (2) determine how effective the humanized version of the scFv is in reversing pain-like behaviors, and (3) test the lead scFv in human cells in culture dishes.

PI_NAMEs: WESTLUND-HIGH, KARIN N. (contact)

PROJECT_TERMS: Acute;Advanced Development;Adverse effects;Affect;Afferent Neurons;Affinity;Affinity Chromatography;Aftercare;Amino Acids;Analgesics;antagonist;Antibodies;Antibody Affinity;antibody test;Antibody Therapy;Anxiety;Behavior;Binding;Biological Products;Brain;Cancer Patient;Cancer Survivor;cancer therapy;cell bank;Cell Line;Cells;Central Nervous System;cGMP production;chemotherapy;Chemotherapy-induced peripheral neuropathy;Chinese Hamster Ovary Cell;Chronic;chronic neuropathic pain;chronic pain;Chronic Phase;Clinical Trials;Complementarity Determining Regions;Data;Deglutition;design;Development;disability;Disabling;Dose;drug candidate;Effectiveness;efficacy evaluation;efficacy study;efficacy validation;Engineering;Ensure;Exhibits;experience;Goals;High Prevalence;Hour;Human;humanized antibody;Hypersensitivity;Immune response;immunogenicity;Immunotherapy;In Vitro;in vitro Model;in vivo;Intellectual Property;Intranasal Administration;Lead;lead optimization;Legal patent;Malignant Neoplasms;manufacture;Mechanics;Methodology;Modeling;Molecular;Monoclonal Antibodies;mouse model;Mus;Muscle Cramp;nanomolar;nerve injury;Nerve Pain;Nervous System;Neurons;neurotoxicity;non-opioid analgesic;novel;opioid epidemic;oxaliplatin;Pain;Pain management;pain model;pain score;painful neuropathy;Parents;Pathologic;Patients;Peptides;Peripheral Nerves;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;Pharyngeal structure;Phase;phase III trial;Platinum;premature;prevent;Production;Proteins;Publishing;Purinoceptor;Quality of life;Rattus;receptor;Reporting;research clinical testing;Response Latencies;Rodent;Role;Safety;Sequential Treatment;single molecule;Single Parent;Site;small molecule;Specific qualifier value;Specificity;Symptoms;System;Testing;Therapeutic;Therapeutic Effect;therapeutic protein;therapeutic target;therapy design;thermostability;Tissues;tool;Touch sensation;Toxic effect;Toxicology;Translating;Treatment Efficacy;treatment response;Validation;validation studies

PROJECT_TITLE: Advancing Development of Novel Immunotherapy for Chemotherapy-induced Peripheral Neuropathy (CIPN)


ORG_CITY: PORTLAND

ORG_NAME: PORTLAND VA MEDICAL CENTER

ORG_STATE: OR

PHR: Neurotrauma, such as traumatic brain injury (TBI) and posttraumatic stress disorder (PTSD), can cause persistent and profound sleep disruption, including abnormally increased muscle tone during rapid eye movement (REM) sleep, or REM sleep behavior disorder (RBD). While RBD has been associated with early synucleinopathy and parkinsonism, the specific predictors and neural pathways by which neurotrauma leads to RBD and synucleinopathy are unknown. We aim to address these gaps using our mouse model of neurotrauma that shows REM sleep abnormalities, in combination with a transgenic mouse model of Parkinson's Disease, as well as test the ability of the botanical curcumin to mitigate synucleinopathy. Results from these studies will provide valuable mechanistic information about the pathophysiology underlying neurotrauma's effects on REM sleep and synucleinopathy. With this critical knowledge, we will take important steps forward in better predicting and mitigating potential neurodegeneration among Veterans with TBI/PTSD.

PI_NAMEs: LIM, MIRANDA M (contact)

PROJECT_TERMS: Acceleration;Address;alpha synuclein;Amygdaloid structure;Animals;Behavior;Behavioral;Behavioral Symptoms;Binding;Botanical dietary supplements;Botanicals;Brain;candidate identification;Cerebrovascular Circulation;Clinical;comorbidity;conditioned fear;Control Groups;controlled cortical impact;Curcumin;Deposition;Development;Disabling;Disease;Dreams;Electroencephalography;Electromyography;epidemiology study;Exposure to;Extinction;Female;Fright;Functional disorder;gait examination;Human;Image;Implant;Individual;innovation;Intervention;Knowledge;male;Methods;Middle East;Military Personnel;Modeling;mouse model;Mus;Muscle Hypertonia;Muscle Tonus;Nerve Degeneration;Nervous System Trauma;Neural Pathways;neuromechanism;neuroprotection;Paralysed;Parkinson Disease;Parkinsonian Disorders;Patients;Pattern;Post-Traumatic Stress Disorders;pre-formed fibril;Predisposition;prevent;Procedures;Process;REM Sleep;REM Sleep Behavior Disorder;Reporting;Risk;segregation;Severities;Skeletal Muscle;Sleep;sleep abnormalities;Sleep disturbances;Stress;Symptoms;synergism;synuclein;synucleinopathy;Testing;Transgenic Mice;trauma exposure;Traumatic Brain Injury;ultrasound;Veterans;Violence

PROJECT_TITLE: Neural mechanisms underlying the connection between Neurotrauma and REM Sleep Behavior Disorder


ADMINISTERING_IC: CA

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Comparative Effectiveness Research;Patient Safety;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: COLUMBUS

ORG_NAME: RESEARCH INST NATIONWIDE CHILDREN'S HOSP

ORG_STATE: OH

PHR: Project Narrative Cure rates for pediatric cancer have improved significantly over the past 30 years due to the enrollment of nearly all affected children in the United States on Children's Oncology Group (COG) clinical trials, and the research completed using biospecimens banked from these studies. The COG Biospecimen Bank aims to support additional pediatric and adolescent cancer research by collecting, processing, and distributing high quality biospecimens.

PI_NAMEs: LOH, MIGNON LEE-CHEUN;RAMIREZ MILAN, NILSA DEL CARMEN (contact);SKAPEK, STEPHEN X

PROGRAM_OFFICER_NAME: LUBENSKY, IRINA

PROJECT_TERMS: Address;Adolescent;Advocate;Affect;anti-cancer research;Basic Science;biobank;Biological;Biological Specimen Banks;Canada;cancer therapy;Child;Childhood;Childhood Cancer Treatment;Clinical;Clinical Research;Clinical Treatment;clinical trial protocol;Clinical Trials;Clinical Trials Cooperative Group;Clinical Trials Network;Collaborations;Collection;Communities;Conduct Clinical Trials;Cooperative Human Tissue Network;Data;Data Coordinating Center;data management;Data Reporting;data sharing;Databases;design;Diagnosis;early phase clinical trial;Education;Enrollment;Ensure;Ethnic Origin;Fostering;Geography;Guidelines;Human;Immunologic Monitoring;Improve Access;improved;informatics tool;Institution;Leadership;Malignant - descriptor;Malignant Childhood Neoplasm;Malignant Neoplasms;Mission;National Clinical Trials Network;operation;Outcome;participant enrollment;Pediatric Hospitals;Pediatric Oncology;Pediatric Oncology Group;Play;population based;Procedures;Process;Protocols documentation;Quality Control;Race;Randomized;Research;Research Institute;Research Personnel;Residual state;Resources;Role;satisfaction;Site;Standardization;success;System;technological innovation;Translational Research;Treatment Side Effects;treatment trial;Tumor Bank;United States;working group

PROJECT_TITLE: COG Biospecimen Bank to Support NCI NCTN (U24)


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Aging;Aphasia;Assistive Technology;Bioengineering;Brain Disorders;Cerebrovascular;Clinical Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Rehabilitation;Stroke

ORG_CITY: PITTSBURGH

ORG_DEPT: PSYCHOLOGY

ORG_NAME: CARNEGIE-MELLON UNIVERSITY

PHR: This project seeks to enhance the value of the AphasiaBank database and tools for the study of spoken language and communication as used by people with aphasia. We will do this through the introduction of innovative methods for automatic speech recognition, discourse analysis, gesture analysis, corpus analysis, and a new system called collaborative commentary. We will apply these new methods to the analysis of the current database, as well as many new corpora. We will configure these new methods for widespread use by both researchers and clinicians.

PI_NAMEs: MACWHINNEY, BRIAN  (contact)

PROJECT_TERMS: Aphasia;automated speech recognition;Communication;Communities;Data;Data Science;Database Management Systems;Databases;design;Discourse analysis;Gestures;Goals;Graph;improved;Indiana;innovation;Instruction;Language;lexical;Manuals;Methods;multimodality;Outcome;Persons;Property;Protocols documentation;Psychometrics;Published Comment;Pythons;Research;Research Personnel;Sampling;shared database;Statistical Data Interpretation;System;Testing;tool;Transcript;United States National Institutes of Health;Universities;web interface;Work

PROJECT_TITLE: AphasiaBank: A Shared Database for the Study of Aphasic Communication

STUDY_SECTION: LCOM

STUDY_SECTION_NAME: Language and Communication Study Section[LCOM]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Antimicrobial Resistance;Emerging Infectious Diseases;Genetics;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza;Prevention

ORG_CITY: BOSTON

ORG_NAME: NORTHEASTERN UNIVERSITY

ORG_STATE: MA

PHR: The goal of this project is to evaluate the properties of darobactins, a novel class of antibiotics we recently discovered, for their properties as potential drug leads. Darobactins act against drug-resistant Gram-negative bacteria, the group of pathogens that presents a critical threat to human health.

PI_NAMEs: LEWIS, KIM  (contact)

PROGRAM_OFFICER_NAME: XU, ZUOYU

PROJECT_TERMS: Acute;Affect;analog;animal efficacy;animal safety;Animals;anti-microbial drug;Antimicrobial Resistance;Bacterial Genome;beta barrel;beta pleated sheet;Binding;Bioinformatics;Biological Assay;cell envelope;Cells;Clinic;Code;COVID-19 pandemic;Cryoelectron Microscopy;cytotoxicity;cytotoxicity test;Data;Databases;Death Rate;Development;Disease;Dose;drug candidate;drug development;Drug resistance;efficacy evaluation;efficacy testing;Escherichia coli;Ethers;Evaluation;experience;experimental study;Fiber;future epidemic;Gene Cluster;genome database;Goals;Gram-Negative Bacteria;Health;Homologous Gene;Human;improved;In Vitro;in vivo;in vivo evaluation;Individual;Infection;Klebsiella pneumoniae;knock-down;Label;Lateral;Life;Link;Location;Lung infections;Lysine;member;Membrane;Metagenomics;Micro Electron Diffraction;Microsomes;Modeling;Modification;Molecular Chaperones;mouse model;Multiple Bacterial Drug Resistance;Mus;Mutagenesis;Mutagenicity Tests;mutant;Nature;Nematoda;novel;novel antibiotic class;Operon;pathogen;Penetration;Peptide Signal Sequences;Peptides;periplasm;Permeability;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;Photorhabdus;Polymyxin Resistance;Predisposition;prevent;Probability;Problem Sets;Production;Property;Proteins;Pseudomonas aeruginosa pneumonia;Resistance;Resistance development;resistance frequency;Ribosomes;scaffold;screening;Sepharose;Septicemia;Societies;Sorting;Structure;Substrate Interaction;Surface;symbiont;Testing;Thigh structure;Thinness;Time;Toxic effect;Translating;Tryptophan;vaccine development;VDAC1 gene;Vertebral column;Virulence;Virus

PROJECT_TITLE: Evaluating darobactins as antimicrobial agents

STUDY_SECTION: DDR

STUDY_SECTION_NAME: Drug Discovery and Mechanisms of Antimicrobial Resistance Study Section[DDR]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE The University of Colorado Cancer Center (UCCC) is an NCI-designated matrix center that brings together 263 cancer researchers from two universities and four clinical entities to drive cancer discovery and innovation. UCCC addresses the cancer needs of its catchment, the State of Colorado, guided by its vision to prevent and conquer cancer. Together. UCCC's mission is to unite its community to overcome cancer through innovation, discovery, prevention, early detection, multidisciplinary care, and education. Exemplary research and adroit leadership, propelled by significant institutional investment has led to impactful innovations in cancer biology that translated into preventative, diagnostic and therapeutic strategies proven in clinical trials, approved by the FDA, and then disseminated to improve the standard of care. UCCC seeks to address the needs of underserved populations by providing targeted, culturally appropriate behavioral interventions, colorectal cancer screenings, and by shaping state tobacco control legislation. CCSG renewal and continuation of institutional commitments of funds and space will allow a continued upward trajectory and enhance the fight against cancer in Colorado.

PI_NAMEs: SCHULICK, RICHARD D (contact)

PROGRAM_OFFICER_NAME: HE, MIN

PROJECT_TERMS: Address;Administrator;Aging;Animals;anti-cancer research;Area;Automobile Driving;Basic Science;Behavior Therapy;bench to bedside;Cancer Biology;Cancer Burden;cancer care;Cancer Center;Cancer Center Support Grant;Cancer Control;cancer prevention;Caring;Catchment Area;Clinic;Clinical;clinical care;Clinical Investigator;Clinical Research;Clinical Trials;Collaborations;Colorado;colorectal cancer screening;Communities;community engagement;Community Outreach;Coordination and Collaboration;COVID-19;Data Science;design;Diagnostic;Disparity population;diversity and inclusion;Early Diagnosis;Education;Ensure;Environment;Equity;FDA approved;fighting;follower of religion Jewish;Fostering;Funding;Future;Goals;Growth;Health;health care delivery;Health Services Research;Hospitals;improved;Informatics;Infrastructure;Infusion procedures;innovation;Institution;interdisciplinary collaboration;Interdisciplinary Study;Intervention;investigator-initiated trial;Investments;Laboratories;Leadership;Learning;Localized Malignant Neoplasm;Malignant Neoplasms;Medical;member;Mentors;Mentorship;Metabolism;Mission;multidisciplinary;next generation;Oncology;operation;Outcome;outreach;patient population;Patient-Centered Care;Patients;Performance;Persons;Policies;Population;population based;population health;prevent;Prevention;Productivity;programs;prospective;recruit;Reduce health disparities;Research;Research Infrastructure;Research Personnel;Resource Sharing;Resources;Science;Scientific Advances and Accomplishments;Scientist;Shapes;Site;Specimen;standard of care;Statutes and Laws;Strategic Planning;Structure;success;Talents;The University of Colorado Cancer Center;Therapeutic;Time;tobacco control;Training;Training and Education;Translating;Translations;Underserved Population;Universities;Vision

PROJECT_TITLE: University of Colorado Cancer Center Support Grant

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


NIH_SPENDING_CATS: Cancer;Prevention

PROJECT_TERMS: Accountability;Activities of Daily Living;Advocacy;anti-cancer research;Area;Cancer Center;Cancer Center Support Grant;cancer clinical trial;cancer research center director;Caring;Clinical;Clinical Data;Clinical Protocols;Clinical Research;Collaborations;Colorado;Communication;Communities;community engagement;Community Outreach;Data;data management;data warehouse;Database Management Systems;Development;Early Diagnosis;Education;Effectiveness;Ensure;Environment;Equipment;Evaluation;Faculty;Faculty Recruitment;farmer;Fees;Fostering;Funding;Funding Opportunities;Goals;Government;Grant;Hospitals;Human Resources;improved;Infrastructure;innovation;Institution;interest;Investments;Leadership;Malignant Neoplasms;Medical center;Medicine;meetings;member;Mission;Monitor;multidisciplinary;Natural Disasters;Occupational activity of managing finances;Office of Administrative Management;operation;pandemic disease;Play;Policies;Population Research;prevent;Prevention;Procedures;Process;programs;Protocols documentation;Public Relations;Publications;recruit;Reporting;Research;Research Design;research vision;Resource Sharing;Resources;Role;Safety;Schools;Services;social media;Strategic Planning;Strategic vision;System;The University of Colorado Cancer Center;Time;tool;Training and Education;Universities;Vision;web site;working group

PROJECT_TITLE: Administrative Office


NIH_SPENDING_CATS: Biotechnology;Cancer;Immunization;Immunotherapy;Lung;Lung Cancer;Orphan Drug;Rare Diseases

ORG_CITY: SAN FRANCISCO

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: Project Narrative Monoclonal antibody (mAb) therapies can drive potent anti-tumor immune responses and have thus become part of the standard of care in the treatment of many cancers, but their efficacy is impeded by diverse cancer resistance mechanisms. This proposal aims to characterize a novel mechanism that enables cancer cells to evade macrophage phagocytosis, which is a major pathway of cancer killing driven by mAbs. Establishment of this novel mechanism using a combination of in vitro and in vivo approaches will advance our understanding of cancer- macrophage interactions and will lay the foundation for therapeutic strategies aimed at counteracting cancer resistance to mAbs.

PI_NAMEs: KAMBER, ROARKE ALEXANDER (contact)

PROGRAM_OFFICER_NAME: KUO, LILLIAN S

PROJECT_TERMS: adaptive immune response;Address;Adipocytes;Affect;anti-cancer;anti-CD20;anti-tumor immune response;Antibodies;antibody-dependent cellular phagocytosis;Antibody-Dependent Enhancement;Antigen Targeting;Biochemical;Bioinformatics;Biological Assay;cancer cell;Cancer Etiology;cancer immunotherapy;Cancer Patient;cancer therapy;cancer type;career;career development;CD47 gene;Cell Extracts;Cell membrane;Cessation of life;Clinical;Communication;Computer Analysis;CRISPR screen;CRISPR/Cas technology;Development;Development Plans;Enabling Factors;Environment;Enzymes;ERBB2 gene;experience;experimental study;fatty acid metabolism;Foundations;functional genomics;Genetic Screening;genome wide screen;Goals;GPR84 gene;Immune;immune cell infiltrate;immune checkpoint;Immune checkpoint inhibitor;Immune response;Immunocompetent;Immunologics;Immunotherapy;improved;In Vitro;in vivo;Inflammatory;innovation;Knock-out;Knowledge;Laboratories;lipid metabolism;Lipids;lung cancer cell;Lymphocyte;Lymphocyte Suppression;Lymphoma;Macrophage;Malignant neoplasm of lung;Malignant Neoplasms;Mediating;Medium chain fatty acid;Membrane Glycoproteins;Membrane Proteins;Mentors;Mentorship;Methods;Modeling;Molecular;Monitor;Monoclonal Antibodies;Monoclonal Antibody Therapy;mouse model;Mus;Natural Killer Cells;neoplastic cell;novel;novel therapeutics;Outcome;Pathway interactions;Patient-Focused Outcomes;Phagocytes;Phagocytosis;Phagocytosis Inhibition;Phase;pre-clinical;Prognosis;Protein Deficiency;receptor;Regulation;Research Personnel;Research Training;Resistance;resistance mechanism;rituximab;Role;Series;Signal Transduction;skills;small cell lung carcinoma;standard of care;success;synergism;technique development;Testing;Therapeutic;Therapeutic Monoclonal Antibodies;therapeutic target;Training;Trastuzumab;tumor;Tumor Antigens;Tumor Cell Line;Tumor Escape;tumor immunology;tumor microenvironment;Universities;Work

PROJECT_TITLE: Systematic Discovery and Characterization of Novel Cancer Anti-Phagocytic Mechanisms

STUDY_SECTION_NAME: Transition to Independence Study Section (I)[NCI-I]


NIH_SPENDING_CATS: Cancer;Immunotherapy

PROJECT_TERMS: Address;anti-cancer research;Applications Grants;Award;Basic Science;cancer care;Cancer Center;Cancer Center Support Grant;cancer education;cancer immunotherapy;Cancer Patient;career;career development;Career Mobility;Catchment Area;Clinical;Clinical Research;Clinical Sciences;Collaborations;Colorado;Communities;community engagement;Community Outreach;Dedications;Development;Doctor of Philosophy;Education;education research;Educational Activities;educational atmosphere;Educational Curriculum;Educational workshop;Ensure;Environment;Ethnic Origin;experience;Faculty;Faculty Recruitment;Fostering;Foundations;Funding;Goals;graduate student;Grant;high school;High School Student;Immunotherapy;improved;Individual;innovation;Investigational Therapies;Investments;junior high school;Latino Population;Leadership;Learning;Malignant Neoplasms;Manuscripts;Medical;Medical Oncology;Medical Students;member;Mentors;Middle School Student;Mission;Monitor;multidisciplinary;next generation;novel;phase I trial;Pilot Projects;Population;population health;Population Sciences;Postbaccalaureate;Postdoctoral Fellow;Program Evaluation;programs;Race;recruit;Research;Research Activity;Research Personnel;Research Training;Resources;Rural Population;Structure;success;Training;Training Activity;Training and Education;Training Programs;Translational Research;Travel;tumor immunology;undergraduate research experience;undergraduate student;Underrepresented Populations;United States Department of Veterans Affairs;Universities;Work;Writing

PROJECT_TITLE: Cancer Research Training and Education Coordination


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Lung Cancer;Palliative Care;Prevention;Rural Health;Social Determinants of Health

PROJECT_TERMS: Acceleration;Address;Aging;anti-cancer research;Antineoplastic Agents;Area;Award;Basic Science;Behavioral;Behavioral Sciences;biobank;Bioinformatics;Biometry;Breast;Cancer Burden;Cancer Center Support Grant;Cancer Control;cancer health disparity;cancer prevention;cancer risk;Cancer Survivorship;career;Caregivers;Catchment Area;Chemoprevention;Chemopreventive Agent;Clinic;Clinical;clinical practice;Clinical Practice Variations;Clinical Research;Clinical Trials;Collaborations;Colorado;Colorectal;Communication;Communities;community engagement;Community Outreach;community setting;Data Sources;Diagnosis;Disparity;disparity reduction;Dysplasia;Early Diagnosis;Economics;Elements;Environmental Exposure;Epidemiologic Methods;epidemiology study;Ethnic Origin;Evidence based practice;experience;Exposure disparity;Family Caregiver;Flow Cytometry;Fostering;frontier;Funding;Future;Genomics;Goals;Grant;Growth;Head and Neck Cancer;Health;Health Disparities Research;health disparity;Health equity research;health inequalities;Health Services Research;Hispanic Populations;Human Papilloma Virus Vaccine;implementation science;improved;improved outcome;Individual;innovation;Institution;Intervention;Investigation;Journals;Laboratories;Leadership;Link;Lung;lung cancer screening;Malignant neoplasm of lung;Malignant Neoplasms;Medical;medical schools;Melanoma;member;Mentors;Metabolism;Mission;Monitor;NCI-Designated Cancer Center;novel strategies;nutrition;older adult;Oncology;Outcome;Palliative Care;Pancreas;Pathology;Patient Care;Pattern;Peer Review Organizations;Personal Satisfaction;Pharmacy Schools;Physical activity;Play;Policies;Policy Research;population based;population health;Prevention;Prevention approach;professor;programs;Psychologist;Public Health;Publications;Publishing;Quality of life;Race;reconstitution;recruit;Research;Research Peer Review;Research Personnel;Research Project Grants;residence;Resource Sharing;Resources;Risk;Risk Factors;Risk Reduction;Role;Rural;rural dwellers;Schools;Science;Scientist;Screening for cancer;Series;Socioeconomic Status;Strategic Planning;stress reduction;Supportive care;survivorship;Training;Training and Education;Translating;Translations;Treatment outcome;United States National Institutes of Health;Universities;uptake;urban disparity;Work

PROJECT_TITLE: Cancer Prevention and Control Program


NIH_SPENDING_CATS: Biotechnology;Cancer;Hematology;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

PROJECT_TERMS: Acute leukemia;Adult;Age;Aging;Animal Cancer Model;Animal Model;Animals;Autologous;Award;Basic Science;bench to bedside;Biological;Biological Markers;Biological Models;biopharmaceutical industry;Biotechnology;Cancer Center;Cancer Center Support Grant;cancer clinical trial;Cancer Control;cancer prevention;Cancer Therapy Evaluation Program;career;Caring;Catchment Area;Cell Therapy;cellular oncology;Childhood;Clinical;clinical application;clinical development;Clinical Research;Clinical Trials;Clinical Trials Network;Collaborations;Colorado;Colorectal Cancer;commercialization;community engagement;Community Outreach;companion animal;comparative;Contracts;Data;design;Development;Developmental Therapeutics Program;Discipline;Disease;drug development;drug discovery;Drug Kinetics;Drug Monitoring;early phase clinical trial;early phase trial;Early Therapeutic-Clinical Trials Network;early-career faculty;Educational Activities;Educational workshop;Enrollment;Evaluation Research;experience;Experimental Models;Faculty;first-in-human;Fostering;Functional disorder;Funding;Future;Goals;Grant;Head;Head and Neck Cancer;Health Services Accessibility;Hematologic Neoplasms;Home;Hospitals;host neoplasm interaction;Image;Immunobiology;Immunotherapy;Improve Access;improved;in vivo;Incubators;Institution;Institutional Review Boards;Intervention;Investigation;Investigational Therapies;investigator-initiated trial;Investments;Journals;Laboratories;Laboratory Research;Lead;Leadership;Link;Malignant Neoplasms;mature animal;Melanoma;member;Mentors;Metabolism;Modality;Modeling;Molecular;molecular oncology;multidisciplinary;NCI-Designated Cancer Center;next generation;novel;novel anticancer drug;novel therapeutic intervention;novel therapeutics;Oncology;oncology program;oncology trial;Organ;Organoids;Outcome;Paper;participant enrollment;Patient Care;patient derived xenograft model;patient population;Patients;Pediatric Hematology;Pediatric Hospitals;Pediatric Oncology Group;pediatric patients;Peer Review;personalized medicine;Pharmaceutical Preparations;Pharmacogenomics;Phase;Pilot Projects;Population;pre-clinical;Pre-Clinical Model;preclinical development;preclinical study;Preclinical Testing;programs;Protocols documentation;Publishing;Quality of life;Rare Diseases;recruit;Research;Research Peer Review;Research Personnel;Resource Sharing;Sampling;Schools;Science;Small Business Innovation Research Grant;Solid;Solid Neoplasm;symposium;System;Testing;The University of Colorado Cancer Center;Therapeutic;tool;Training;Translating;Translational Research;Translations;treatment trial;United States Department of Veterans Affairs;United States National Institutes of Health;Universities;Validation;Work;Xenograft procedure

PROJECT_TITLE: Developmental Therapeutics Program


PROJECT_TERMS: Adult;Aging;Aneuploidy;Animal Model;anti-cancer research;Automobile Driving;Autophagocytosis;Basic Science;BCL1 Oncogene;bench to bedside;Bioinformatics;Biological Sciences;Biometry;Biotechnology;BRAF gene;cancer cell;Cancer Center;Cancer Center Support Grant;cancer diagnosis;cancer genome;Cancer Patient;cancer prevention;cancer therapy;career development;Catchment Area;Cell Fate Control;Cells;Cellular biology;cellular oncology;chemotherapy;Chloroquine;Chromatin Remodeling Factor;Clinical;Clinical Research;Clinical Trials;Collaborations;Colorado;Combined Modality Therapy;Communities;community engagement;Community Outreach;Copy Number Polymorphism;CRISPR screen;Custom;Databases;Dependence;design;Development;Diagnosis;Disease;Disease remission;DNA amplification;DNA Damage;DNA Repair;Down's Syndrome;Drug resistance;Epigenetic Process;epigenetic regulation;Equilibrium;experience;experimental study;Flow Cytometry;follower of religion Jewish;Fostering;FRAP1 gene;functional genomics;fundamental research;Funding;Future;Gene Expression;Genes;Genetic;Genetic Screening;Genetic study;Genetic Transcription;genome integrity;Genomic Instability;Genomics;Goals;Grant;Guide RNA;Head and neck structure;Health;Hematologic Neoplasms;Histone Deacetylase Inhibitor;improved;Individual;inhibitor;insight;Institution;interdisciplinary collaboration;Investigation;Jordan;Journals;kinase inhibitor;Knowledge;Leadership;leukemic stem cell;Lung;Malignant Breast Neoplasm;Malignant neoplasm of brain;Malignant Neoplasms;MAP Kinase Gene;MAPK Signaling Pathway Pathway;MDM2 gene;Mediator;Medical;Medicine;member;Mentors;Metabolic;Metabolism;Mission;model organism;Molecular;molecular oncology;Molecular Structure;Mutation;Nature;new combination therapies;new technology;novel;novel diagnostics;novel therapeutic intervention;novel therapeutics;oncology program;Pathology;Pathway interactions;Patients;Peer Review;personalized medicine;pre-clinical;Predisposition;Process;prognostic value;programs;promoter;Proteins;Publications;Publishing;Radiation-Sensitizing Agents;Research;Research Peer Review;Research Personnel;Resistance;Resource Sharing;Resources;response;RNA;RNA library;RNA Processing;Science;Signal Transduction;Site;structural biology;Technology;Telomerase;telomere;Testing;The University of Colorado Cancer Center;Therapeutic;Time;TP53 gene;Training;Training Programs;Translating;Translational Research;Translations;tumor progression;Underserved Population;Universities;Woman

PROJECT_TITLE: Molecular and Cellular Oncology Program


NIH_SPENDING_CATS: Biotechnology;Cancer;Immunotherapy

PROJECT_TERMS: Adaptive Immune System;Address;Adipocytes;Adult;Adverse event;Affect;Age;Aging;American Cancer Society;animal imaging;anti-cancer research;Antibodies;Antigens;Autoimmunity;Basic Science;Bioinformatics;Biomanufacturing;Biometry;Blood Vessels;Cancer Center;Cancer Center Support Grant;CD19 gene;Cell Therapy;cell type;Cells;chemokine;Child;chimeric antigen receptor;Clinical;clinical translation;Clinical Trials;Collaborations;Colorado;Communities;Complex Mixtures;cost;cytokine;Development;Disease Progression;Doctor of Philosophy;Educational workshop;Endocrine;Epigenetic Process;Extracellular Matrix;Faculty;Family;first-in-human;Flow Cytometry;Fostering;functional genomics;Funding;Future;Genomics;Goals;Grant;Heme;Hormonal;Hormones;host neoplasm interaction;Human;Immune;Immune Evasion;Immune system;Immunologic Monitoring;Impairment;In Vitro;in vivo Model;Inflammatory;Infrastructure;Innate Immune System;innovation;Institution;instrumentation;Interleukin-1;Intervention;investigator-initiated trial;Investments;Journals;Leadership;Life Style;Lymphangiogenesis;Malignant Neoplasms;manufacture;mass spectrometry shared resource;member;Mentors;Mentorship;Metabolic;Metabolism;Modeling;Molecular;mouse model;multidisciplinary;Mutation;next generation;novel;novel therapeutic intervention;Obesity;Oncogenes;Oncology;operation;Pathogenesis;Pathologic;Pathology;Pediatric Hospitals;Peer Review;permissiveness;Persons;Physician Executives;Physicians;Physiological;Physiology;Pilot Projects;postpartum breast cancer;pre-clinical;Pre-Clinical Model;preclinical study;Predisposition;Pregnancy;Prevention strategy;Privatization;Production;professional atmosphere;programmed cell death ligand 1;programs;Property;Puberty;Publications;Research;research clinical testing;Research Personnel;Research Project Grants;Resource Sharing;Resources;Role;Science;Scientist;Site;Solid Neoplasm;spectrograph;success;Systems Biology;Testing;The University of Colorado Cancer Center;Therapeutic;therapy resistant;Tissues;Training and Education;Translating;Translational Research;treatment response;treatment strategy;tumor;tumor heterogeneity;tumor immunology;tumor initiation;tumor metabolism;tumor microenvironment;tumor progression;tumor-immune system interactions;Tumor-infiltrating immune cells;Universities;University Hospitals;Whole Organism;Work

PROJECT_TITLE: Tumor-Host Interactions Program


PROJECT_TERMS: Acceleration;Accountability;Articulation;Cancer Center;Cancer Center Support Grant;Cancer Patient;Caring;Catchment Area;Clinical;clinical care;Collaborations;Colorado;Communication;Communities;Community Outreach;Discipline;Early Diagnosis;Education;Education and Outreach;Evaluation;experience;follower of religion Jewish;Fostering;Funding;Goals;Health;improved outcome;Incentives;Incidence;Infrastructure;innovation;Institution;Investments;Leadership;Malignant Neoplasms;Medical;member;Mission;multidisciplinary;prevent;Prevention;Process;recruit;Research;Research Personnel;Resource Sharing;Role;Scientist;Stimulus;Strategic Planning;synergism;The University of Colorado Cancer Center;translational impact;Universities;Vision;Work

PROJECT_TITLE: Leadership, Planning and Evaluation


NIH_SPENDING_CATS: Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Rural Health;Social Determinants of Health

PROJECT_TERMS: Address;Advocacy;Affect;anti-cancer research;Area;Arizona;Cancer Burden;Cancer Center;Cancer Center Support Grant;Cancer Control;cancer health disparity;cancer prevention;Cancer Research Project;cancer risk;Cancer Survivor;Caring;Catchment Area;cellular oncology;Church;Clinical;Clinical Trials;Collaborations;Colorado;Communication;Communities;community center;Community Developments;community engagement;Community Health;Community Hospitals;community organizations;Community Outreach;Community Participation;community partners;community partnership;Data;Databases;Developmental Therapeutics Program;Diagnosis;Disparity;Disparity population;disparity reduction;Dissemination and Implementation;Education;Educational Activities;Educational workshop;Environment and Public Health;Environmental Exposure;Faith-based organization;Funding;Future;Goals;Government;Health;health assessment;health equity;Health Sciences;Healthcare;Healthcare Systems;Hispanic;Hospitals;host neoplasm interaction;Human papilloma virus infection;improved;Infrastructure;Institution;Intervention;Investigation;investigator training;Joints;Laws;Leadership;Link;Malignant Neoplasms;Measures;meetings;member;Mission;molecular oncology;mortality;NCI Center for Cancer Research;NCI-Designated Cancer Center;neoplasm registry;New Mexico;Outcome;outreach;Patients;Persons;Pilot Projects;Policies;population based;population health;Prevention;primary care clinic;Primary Health Care;Process;programs;Research;Research Personnel;Research Project Grants;Resource Sharing;Risk;Risk Factors;Rural;Rural Community;safety net;Schools;Science;screening;Services;Smoking;Strategic Planning;survivorship;The University of Colorado Cancer Center;Training;Training and Education;Translational Research;treatment program;Underserved Population;Universities;Utah;Vulnerable Populations;Work

PROJECT_TITLE: Community Outreach and Engagement


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Prevention

PROJECT_TERMS: Acceleration;Achievement;Address;Aging;anti-cancer research;Applications Grants;Area;Articulation;Attention;Award;Behavior;Behavioral Sciences;Cancer Biology;Cancer Burden;cancer care;Cancer Center;Cancer Center Support Grant;Cancer Control Research;cancer prevention;cancer risk;Cancer Science;care delivery;care outcomes;Clinic;Clinical Sciences;cohort;Collaborations;Colorado;Communities;community engagement;Community Outreach;Critiques;Data;data resource;Databases;Development;Early Diagnosis;Ensure;evidence base;Faculty;Focus Groups;Fostering;Funding;Future;Goals;Grant;Growth;health economics;health inequalities;Health Services;informant;innovation;Institution;Intervention;Interview;Investments;Leadership;Malignant Neoplasms;Measurement;Medical;Medicine;member;Mentors;Metabolism;Methods;Mission;Monitor;multidisciplinary;NCI Center for Cancer Research;Outcome;Patients;Peer Review;Peer Review Grants;Philanthropic Fund;Pilot Projects;Population;population health;Population Sciences;Prevention;Process;Program Development;Program Research Project Grants;programs;Publications;Reporting;Research;Research Activity;research and development;Research Design;Research Methodology;Research Personnel;Research Project Grants;Resource Sharing;Resources;Science;Secure;service delivery;Services;Source;Strategic Planning;success;Surveys;synergism;Technology;The University of Colorado Cancer Center;tool;Training and Education;Translating;Universities;Vision

PROJECT_TITLE: Developmental Funds


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Patient Safety;Social Determinants of Health

PROJECT_TERMS: Address;anti-cancer research;Area;Awareness;Budgets;Cancer Center Support Grant;cancer clinical trial;Cancer Therapy Evaluation Program;Catchment Area;Cell Therapy;Clinical;Clinical Data;clinical implementation;clinical investigation;Clinical Oncology;Clinical Protocols;Clinical Research;Clinical Research Protocols;clinical research site;Clinical Sciences;Clinical Trials;Clinical Trials Cooperative Group;Clinical Trials Network;Clinical Trials Support Unit;Collaborations;Colorado;community engagement;Community Outreach;Contracts;County;Data;data management;demographics;Development;Developmental Therapeutics Program;Early Therapeutic-Clinical Trials Network;Education;education resources;Educational Curriculum;electronic medical record system;Enrollment;Ensure;Faculty;Feedback;Funding;Health;Hematology;high risk;Hispanic;Hour;improved;Industry;Infrastructure;innovation;Intervention;Investigational Therapies;investigator training;investigator-initiated trial;Investments;Knowledge;Lead;Malignant Neoplasms;Medical center;member;Minority Groups;minority patient;Monitor;Multi-Institutional Clinical Trial;multidisciplinary;Nurses;Oncology;operation;outreach;participant safety;Pathway interactions;patient safety;Patients;Peer Review;Phase;Phase II Clinical Trials;Policies;Population;population health;Population Sciences;Prevention trial;Process;process optimization;programs;Protocols documentation;Qualifying;quality assurance;Quality Control;Recording of previous events;Regulation;Reporting;repository;Research;Research Activity;Research Personnel;research study;Research Support;Resources;Rural;Safety;Services;Site;socioeconomic diversity;Solid Neoplasm;Structure;Subgroup;System;Therapy trial;Time;Training;Training and Education;Translational Research;treatment trial;Underrepresented Minority;Underserved Population;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Clinical Protocol and Data Management


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

PROJECT_TERMS: Amendment;anti-cancer research;Appropriateness Review;Bylaw;Cancer Center;Cancer Center Support Grant;cancer clinical trial;cancer research center director;Clinical;Clinical Research;Clinical Trials;Collaborations;Colorado;Committee Members;Committee Membership;community engagement;Community Outreach;Data;data quality;design;Discipline;Disease;Enrollment;Ensure;Evaluation;Grant;Human;Industry;Institution;Institutional Review Boards;Intervention;Intervention Studies;Intervention Trial;investigator-initiated trial;Leadership;Letters;Malignant Neoplasms;member;Minority Groups;Modification;Monitor;National Clinical Trials Network;NCI Center for Cancer Research;Peer Review;Principal Investigator;Procedures;programs;Protocols documentation;recruit;Reporting;Research Personnel;Research Priority;research study;Review Committee;Safety;Study Subject;System;The University of Colorado Cancer Center;Underrepresented Minority;Underserved Population;Universities;welfare

PROJECT_TITLE: Protocol Review and Monitoring System


PROJECT_TERMS: Adopted;Advanced Malignant Neoplasm;Aging;animal imaging;anti-cancer research;Back;Basic Science;Bioinformatics;Biometry;cancer cell;Cancer Center;Cancer Center Support Grant;Capital;Cells;Charge;Chromium;Collaborations;Colorado;cost;Cryoelectron Microscopy;Data;Data Science;Decision Making;Development;drug development;drug discovery;Education;empowerment;Ensure;Equipment;Evaluation;Exposure to;Faculty;Feedback;Flow Cytometry;functional genomics;Funding;Future;Genomics;Goals;high resolution imaging;high-throughput drug screening;Human;Immune system;Immunologic Monitoring;Immunology;improved;Information Networks;innovation;Institution;interest;Investments;Journals;Laboratory Technicians;liquid crystal polymer;Magnetic Resonance Imaging;Malignant Neoplasms;mass spectrometer;Mass Spectrum Analysis;Medicine;member;Modeling;mouse model;Nature;new technology;novel;Organoids;Pathology;Peer Review;Performance;population health;Postdoctoral Fellow;pre-clinical;Process;Publications;Qualifying;Research;Research Infrastructure;Research Personnel;Resource Sharing;Resources;Running;Services;single cell sequencing;Strategic Planning;structural biology;Structure;Students;Suggestion;System;Techniques;Technology;The University of Colorado Cancer Center;time use;Training;transcriptome sequencing;Translations;Tumor Biology;tumor immunology;Universities;Update

PROJECT_TITLE: Shared Resource Management


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Pediatric;Prevention;Primary Immunodeficiencies;Racial and Ethnic Minority Health Research;Rare Diseases;Social Determinants of Health

ORG_CITY: Canton

ORG_NAME: HARVARD PILGRIM HEALTH CARE, INC.

PHR: PROJECT NARRATIVE Knowledge generated from the proposed research will provide an evidence base for addressing disparities in the diagnosis of primary immune deficiency (PID) among racial and ethnic minorities. Because early diagnosis and treatment of PID are crucial for the prevention of permanent organ damage and death, addressing disparities in PID diagnosis will have a significant public health impact and is relevant to NIMHD’s mission to improve minority health and reduce health disparities.

PI_NAMEs: FARMER, JOCELYN R;ONG, MEI-SING  (contact)

PROGRAM_OFFICER_NAME: PADGETT, LYNNE SLAUGHTER

PROJECT_TERMS: Address;Affect;Antibodies;Autoimmunity;Awareness;Belief;Boston;California;Caring;Cessation of life;Clinical;Clinical Data;Clinical Immunology;comorbidity;Complex;congenital immunodeficiency;Data;Data Set;Defect;design;Diagnosis;Diagnostic;Diagnostic Factor;Diagnostic tests;Disease;Disparity;Disparity in diagnosis;Early Diagnosis;Early treatment;Education;Education and Outreach;Educational Intervention;Effectiveness;Electronic Health Record;ethnic minority;Ethnic Population;evidence base;experience;Focus Groups;follow-up;Foundations;General Hospitals;Goals;Health;Health Personnel;Healthcare Systems;Hospital Referrals;Hospitals;Hypersensitivity;Immune;Immune system;Immunologic Deficiency Syndromes;improve minority health;improved;Infant;Inflammation;innovation;Intervention;Interview;Knowledge;knowledge integration;Learning;Lived experience;Low income;Machine Learning;machine learning method;Malignant Neoplasms;Massachusetts;Medical center;medical specialties;Minority;Minority Groups;minority patient;Mission;Mutation;National Institute on Minority Health and Health Disparities;Natural History;Neonatal Screening;New England;Not Hispanic or Latino;Organ;outreach program;Paint;Patients;Pattern;Pattern Recognition;Persons;Play;Population;Prevalence;Prevention;programs;Public Health;Publishing;racial minority;recurrent infection;Reduce health disparities;Reporting;Research;Risk Factors;Role;safety net;screening;Severe Combined Immunodeficiency;social health determinants;Underserved Population;Woman

PROJECT_TITLE: Underdiagnosis of primary immunodeficiency disorders among racial and ethnic minorities: Recognize and Educate

STUDY_SECTION: HHD

STUDY_SECTION_NAME: Healthcare and Health Disparities Study Section[HHD]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Cardiovascular;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Hypertension;Networking and Information Technology R&D (NITRD);Neurosciences;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health;Stroke;Telehealth

ORG_CITY: HOUSTON

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: Project Narrative The purpose of this project is to perform a randomized comparative effectiveness trial to assess the impact of a multidisciplinary telehealth intervention aimed at improving outpatient blood pressure control and decreasing disparities in blood pressure control in a racially and ethnically diverse cohort of ischemic and hemorrhagic stroke survivors by incorporating a social determinants of health approach into the care model. Hospitalized stroke survivors will be enrolled in the study prior to hospital discharge. Post-stroke care for stroke survivors enrolled in the intervention will include remote BP monitoring, video visits, and an integrated approach to care by a multidisciplinary team that includes a social worker, pharmacist, and stroke clinical provider.

PI_NAMEs: SHARRIEF, ANJAIL Z (contact)

PROJECT_TERMS: Accident and Emergency department;Acute;acute care;Address;Adult;Ambulatory Blood Pressure Monitoring;Ambulatory Care;Area;Behavior;Black race;Blood Pressure;blood pressure control;Blood Pressure Monitors;blood pressure reduction;Blood Vessels;Brain hemorrhage;care delivery;care systems;Caring;Cessation of life;Cities;Clinical;cohort;Communities;comparative effectiveness trial;Coronary;COVID-19 pandemic;Data;Discrimination;Disparity;disparity reduction;Effectiveness;Enrollment;Environment;ethnic disparity;ethnic diversity;Ethnic Origin;Event;evidence based guidelines;experience;follow-up;food insecurity;health care service utilization;health service use;Health Services;Health Services Accessibility;Healthcare;Heart failure;Heterogeneity;Hispanic;Home;hospital readmission;Hospitalization;Hospitals;Hour;Hypertension;Improve Access;improved;indexing;individual patient;Inpatients;Insurance;Insurance Coverage;integrated care;interdisciplinary approach;Intervention;intervention effect;Ischemic Stroke;Language;Link;Measures;Medicaid;Medical;metropolitan;Modeling;mortality;multi-component intervention;multidisciplinary;Myocardial Infarction;Neighborhoods;Neurologist;Neurology;Nurse Practitioners;Outcome;outcome disparities;Outpatients;Patients;Pharmacists;Physicians;post intervention;post stroke;predictive modeling;primary care provider;primary outcome;programs;Provider;Race;racial disparity;racial diversity;racism;Randomized;randomized trial;recruit;Recurrence;Research;Resources;revascularization;Risk;Risk Assessment;Risk Factors;secondary outcome;segregation;social;social health determinants;Social support;social vulnerability;Social Workers;Socioeconomic Status;standard care;Stroke;stroke risk;stroke survivor;Survivors;System;Technology;telehealth;Telemedicine;telemonitoring;Testing;Transient Ischemic Attack;treatment and outcome;trial comparing;Uninsured;United States;urgent care;video visit;virtual intervention;virtual model;Visit

PROJECT_TITLE: Video-based Intervention to Reduce Treatment and OUtcome Disparities in Adults Living with Stroke or Transient Ischemic Attack (VIRTUAL)

STUDY_SECTION: HSQE

STUDY_SECTION_NAME: Health Services: Quality and Effectiveness Study Section[HSQE]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Mental Illness;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: PHILADELPHIA

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: DREXEL UNIVERSITY

PHR: Latinos in the U.S. experience significant disparities in access to mental health services due to lack of health  insurance, language barriers, low availability of bilingual providers, mental health stigma, and fear of  deportation. There is an urgent need to identify low-cost, culturally appropriate interventions to reduce mental  health disparities among this population. This project will address that need by implementing and testing  CRISOL Mente, a multi-level, culturally-congruent intervention to improve the mental health of the Latino  population in Philadelphia.

PI_NAMEs: LAZO ELIZONDO, MARIANA ;MARTINEZ-DONATE, ANA P (contact)

PROGRAM_OFFICER_NAME: BARKSDALE, CRYSTAL

PROJECT_TERMS: access disparities;Acute;Address;Adherence;Advocacy;Awareness;barrier to care;bilingualism;Caring;Client;Clinic;clinical anxiety;Clinical Data;cohort;Communication;Communities;community engaged research;community intervention;Community Outreach;community setting;Community Surveys;Complex;cost;Coupled;COVID-19 pandemic;cultural competence;culturally appropriate intervention;Data;design;Development;Discrimination;Disparity;disparity reduction;Economics;Education;Education and Outreach;Educational Activities;Educational Status;Effectiveness;effectiveness testing;Evaluation;Evidence based treatment;experience;follow-up;Fright;Health;health care availability;health disparity;Health Insurance;Health Resources;Health Services Accessibility;Healthcare;Immigrant;improve minority health;improved;informant;Intervention;Interview;Language;Latina;Latino;Latino Population;Legal;Limited English Proficiency;Linguistics;member;men;Mental Depression;Mental disorders;Mental Health;Mental Health Services;Methods;Modeling;Newsletter;Not Hispanic or Latino;novel;Occupations;Outcome;outreach;Patients;peer;Phase;Philadelphia;Population;post-COVID-19;post-traumatic stress;Poverty;programs;Provider;psychological distress;Public Health;racism;Radio;Reach, Effectiveness, Adoption, Implementation, and Maintenance;recruit;Reduce health disparities;Reporting;Research;Resource-limited setting;Resources;Respondent;Rest;Risk;Sampling;screening;Services;Site;Social Conditions;social stigma;Social Work;Stress;Surveys;Symptoms;syndemic;Syndrome;Testing;Training;Woman

PROJECT_TITLE: CRISOL Mente: A Multilevel Community Intervention to Reduce Mental Health Disparities Among Latinos


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Colorectal Cancer;Digestive Diseases;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Networking and Information Technology R&D (NITRD);Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health;Telehealth

ORG_CITY: Oakland

ORG_NAME: KAISER FOUNDATION RESEARCH INSTITUTE

PHR: NARRATIVE Colorectal cancer screening among Latinx populations lags far behind that of non-Latinx White populations. We will test a program that pairs video-texting with neighborhood navigation services to improve colorectal cancer screening for adults who are new to screening or have never been screened. Our program could serve as a model for sharing accurate health information and promoting healthy behavior for a variety of diseases.

PI_NAMEs: CORONADO, GLORIA D;ESCARON, ANNE LAURE;PETRIK, AMANDA F. (contact)

PROGRAM_OFFICER_NAME: WHITE, DOLLY PENN

PROJECT_TERMS: access disparities;Address;Adoption;Adult;aged;Area;Awareness;barrier to care;Behavior;cancer care;cancer prevention;cancer survival;care delivery;care systems;Caring;Clinic;Clinical;Clinical Medicine;clinical practice;Colorectal Cancer;colorectal cancer screening;Communication;Communities;community based service;Community Health;Community Networks;community organizations;community partners;community partnership;Data;design;Detection;Disease;Disparity;disparity reduction;Effectiveness;effectiveness testing;Eligibility Determination;Emotional;Ensure;Equity;Ethnic Origin;Evaluation;evidence base;Face;follow-up;Food;Gastroenterology;Geographic Information Systems;Goals;Guidelines;Health;health care delivery;health care model;health disparity;health equity;Health Services Accessibility;Health Services Research;Health system;Healthcare;implementation facilitators;implementation framework;implementation science;improved;Individual;Interdisciplinary Study;Intervention;Knowledge;Language;Latinx;Latinx population;Link;Los Angeles;Malignant Neoplasms;Measures;member;Methods;Misinformation;Modeling;Neighborhood Health Center;Neighborhoods;novel;older adult;Outcome;patient engagement;patient oriented;Patients;Pattern;Population;pragmatic study;prevention service;Preventive;Preventive care;Process;Program Effectiveness;Program Sustainability;programs;rapid technique;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Research;Research Methodology;Research Personnel;Resources;scale up;Scientist;screening;screening disparities;Screening for cancer;screening services;Services;Shapes;Site;social;social competition;social health determinants;Subgroup;success;Survival Rate;systems research;Technology;telehealth;telehealthcare;Testing;Text Messaging;tool;Transportation;Trust;United States Preventative Services Task Force;uptake;video delivery

PROJECT_TITLE: Community Partnership for Telehealth Solutions to Counter Misinformation and Achieve Equity (PRIME)


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Colorectal Cancer;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Racial and Ethnic Minority Health Research;Rare Diseases;Social Determinants of Health

ORG_CITY: HYATTSVILLE

ORG_NAME: MEDSTAR HEALTH RESEARCH INSTITUTE

ORG_STATE: MD

PHR: This proposal aims to employ artificial intelligence (AI) and natural language processing (NLP) technologies and conduct a randomized clinical trial to examine how a voice-assisted, remote patient symptom monitoring system (VARSMS) can reduce ethnoracial disparities after gastrointestinal (GI) cancer surgery. Black and Hispanic patients experience more difficult social and medical conditions while recovering at home than white patients, which makes a home-based “smart” intervention potentially transformative. Further, our system would replace less flexible and adaptable telephone-based systems currently in use.

PI_NAMEs: AL-RAFAIE, WADDAH B.;SHARA, NAWAR  (contact)

PROJECT_TERMS: Address;Adverse event;Artificial Intelligence;Attention;Black race;cancer care;Cancer Patient;cancer surgery;Caring;Cessation of life;Cholangiocarcinoma;Clinical;Clinical Trials;Collection;Colorectal Cancer;Communication;cost;COVID-19;Devices;Disparity;Disparity population;disparity reduction;Effectiveness;effectiveness evaluation;efficacy evaluation;Emergency department visit;ethnic health disparity;ethnoracial;ethnoracial disparity;ethnoracial minority;Event;experience;flexibility;follow-up;Friends;gastroesophageal cancer;Gastrointestinal Surgical Procedures;gastrointestinal symptom;Goals;Health;health care disparity;health information technology;Health Services Research;Health system;Healthcare Systems;Hispanic;Home;hospital readmission;Hospitals;improved;Informatics;innovation;innovative technologies;Inpatients;Intervention;Intuition;low health literacy;Malignant neoplasm of gastrointestinal tract;Malignant neoplasm of liver;Malignant neoplasm of pancreas;Marketing;Medical;Mid-Atlantic Region;Minority;minority patient;mobile application;Modeling;Monitor;multidisciplinary;Natural Language Processing;Operative Surgical Procedures;Outcome;patient oriented;patient-clinician communication;Patients;Phase;pilot test;Postoperative Care;Postoperative Period;Predictive Factor;Provider;provider adherence;racial disparity;randomized, clinical trials;Reporting;Research;response;safety net;Sampling;smart speaker;social;Social Problems;Strategic Planning;Structural Racism;success;surgery outcome;Symptoms;System;Technology;telephone based;tool;United States National Institutes of Health;Voice

PROJECT_TITLE: REmote symptom COllection to improVE postopeRative care (RECOVER)


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cancer;Cervical Cancer;Clinical Research;Data Science;HPV and/or Cervical Cancer Vaccines;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Immunization;Infectious Diseases;Networking and Information Technology R&D (NITRD);Pediatric;Prevention;Rare Diseases;Sexually Transmitted Infections;Social Determinants of Health;Urologic Diseases;Vaccine Related;Women's Health Research

ORG_CITY: CHARLESTON

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: PROJECT NARRATIVE The uptake of the human papillomavirus (HPV) vaccine is suboptimal among low-income children and adolescents in Texas. This project will utilize state-of-the-art data mining techniques to determine area-level HPV vaccination rates, will implement geospatial approaches to identify hotspots of poor HPV vaccination rates, and will disseminate evidence-based resources for improving HPV vaccination rates. The long-term goal of this project is to increase the HPV vaccination rates among low-income children and adolescents to reduce HPV-associated cancer disparities.

PI_NAMEs: SONAWANE, KALYANI  (contact)

PROJECT_TERMS: 17 year old;Acceleration;Address;Adolescent;aged;American;American Cancer Society;Anus;Area;Big Data;Biometry;boys;cancer health disparity;cancer prevention;Centers for Disease Control and Prevention (U.S.);Cervical;Cervical Cancer Screening;Child;Child Health;Childhood;cost;Data;Data Analyses;Data Analytics;data mining;Data Science;data visualization;Databases;Diagnosis;Digit structure;Disparity;dissemination science;Dose;Eligibility Determination;Ensure;Ethics;evidence base;Foundations;Funding;Geographic Locations;Geography;girls;Goals;health care service utilization;Health Disparities Research;Health Insurance;Health Personnel;Health Services;Health Services Research;Healthcare;Herd Immunity;Household;HPV vaccine acceptance;Human Papilloma Virus Vaccination;Human Papilloma Virus Vaccine;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;implementation science;improved;Incidence;Individual;Insurance;Low income;low socioeconomic status;lower income families;Malignant neoplasm of anus;Malignant neoplasm of cervix uteri;Malignant neoplasm of penis;Malignant neoplasm of vulva;Malignant Neoplasms;malignant oropharynx neoplasm;Malignant Vaginal Neoplasm;Measures;Medicaid;Mentored Research Scientist Development Award;Mentors;Mentorship;Methodology;Methods;Modeling;novel;Oropharyngeal;outreach;penis;Pharmacists;Play;Population;population health;Positioning Attribute;prevent;programs;Provider;provider intervention;Public Health;public health insurance;Qualifying;Recommendation;Research;Research Personnel;Resources;Risk;Risk Reduction;Role;Rural;Series;Structure;Subgroup;suburb;Techniques;Texas;Training;Vaccinated;Vaccination;Vaccines;Vagina;Visualization;Vulnerable Populations;Vulva;web portal;Work

PROJECT_TITLE: Harnessing Big Data to Identify Geographic Clusters of Low-income children with Poor HPV Vaccination Rates


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;HIV/AIDS;Infectious Diseases;Mental Health;Neurodegenerative;Neurosciences;Parkinson's Disease;Prevention

ORG_CITY: MENLO PARK

ORG_NAME: SRI INTERNATIONAL

PHR: PROJECT NARRATIVE The HIV-infected population is surviving into old age, thanks to medicine regimens that are successful in lowering deadly viral loads, such that 47% (454,684) of Americans living with HIV/AIDS are aged 50 years and older. Despite the efficiency of antiretroviral therapy in reducing viral burden, those with HIV/AIDS remain especially open to accelerated neurocognitive declines of aging, added neural burden from heavy alcohol consumption, substance use, and organ system injury, and vulnerable to neurodegenerative disorders with older age such as Parkinson's disease (PD). Using the NIMH's Research Domain Criteria (RDoC), this research will contribute to public health utilizing brain imaging methods to discover neuroimaging biomarkers for emerging parkinsonism and accelerated cognitive decline beyond that of normal ageing and potentially modifiable factors such as sleep and daytime physical activity, which together can lead to advances in preventative therapy to be applied during midlife to counteract progression and reduce future disease burden.

PI_NAMEs: SCHULTE, TILMAN  (contact)

PROGRAM_OFFICER_NAME: ST  HILLAIRE-CLARKE, CORYSE

PROJECT_TERMS: Acceleration;Acquired Immunodeficiency Syndrome;actigraphy;Adherence;Affect;Age;age related neurodegeneration;aged;Aging;Alcohol consumption;Alcohols;American;antiretroviral therapy;Arousal and Regulatory Systems;Basal Ganglia;Behavioral;biomarker discovery;Body System;Bradykinesia;Brain;Brain imaging;brain pathway;burden of illness;California;CD4 Lymphocyte Count;Central Nervous System;Central Nervous System Diseases;Chronic;Cognition;Cognitive;Cognitive deficits;Cohort Studies;Degradation Pathway;diagnostic signature;Disease;Disease Progression;Ethnic Origin;experience;follow-up;Frequencies;frontal lobe;Functional disorder;functional independence;Functional Magnetic Resonance Imaging;Future;General Population;Health;Heterogeneity;HIV;HIV Infections;HIV-associated neurocognitive disorder;HIV/AIDS;human old age (65+);imaging modality;immunosenescence;Impaired cognition;Impairment;indexing;Individual;information processing;Injury;inter-individual variation;Intervention;Life;Life Expectancy;Link;Longitudinal Studies;Magnetic Resonance Imaging;Measures;Mediating;Medical;Medicine;Memory;middle age;mild cognitive impairment;Modernization;modifiable risk;Morphology;mortality;Motor;motor deficit;Motor disability;motor impairment;Movement;multidisciplinary;National Institute of Mental Health;Nerve Degeneration;neural;Neurocognitive;Neurocognitive Deficit;Neurodegenerative Disorders;neuroimaging;neuroimaging marker;Neurologic;neuropathology;Neuropsychology;normal aging;novel;Older Population;organ injury;Parkinson Disease;Parkinsonian Disorders;Pathway interactions;Pattern;Performance;Peripheral;Persons;Physical activity;Population;predictive marker;Preventive therapy;Process;processing speed;Public Health;Quality of life;Race;recruit;Regimen;regional atrophy;Reporting;Research;Research Domain Criteria;Research Personnel;resilience;response;Rest;Risk;Risk Factors;Role;Severities;sex;Sleep;sleep quality;sociodemographic factors;Socioeconomic Status;Substance abuse problem;substance use;Symptoms;Telephone;Time;United States;Viral;Viral Load result;Visit;Visuospatial;Work

PROJECT_TITLE: Neurofunctional Mechanisms of Changes in Cognition and Motor Function in Aging with HIV and Parkinson's Disease


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: NEW HAVEN

ORG_DEPT: PSYCHIATRY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative This innovative proposal will address financial wellbeing, an often overlooked but important factor impacting reentry for justice-involved people with mental health challenges, who are disproportionately Black and Latinx. The project will change community level determinants by integrating financial capability support (one-on-one coaching and access to financial tools and services) into existing services and training bank and credit union staff to reduce discrimination. It will also support collaborative community efforts working towards upstream policy and legal reforms to reduce the incidence of those financial challenges.

PI_NAMEs: BELLAMY, CHYRELL DENISE;HARPER, ANNIE  (contact)

PROGRAM_OFFICER_NAME: MUJURU, PRISCAH

PROJECT_TERMS: Address;Affect;Attention;Behavior;Black race;Collaborations;Communities;community based participatory research;community collaboration;community intervention;community partners;community reentry;Criminal Justice;Data;disability;Discrimination;Employment;empowerment;Environment;Exclusion;experience;Feeling;Financial Hardship;Goals;Health;health determinants;Health Knowledge Attitudes Practice;Health Services Accessibility;Housing;Imprisonment;improved;Incidence;Income;Individual;innovation;Institution;Intervention;Jail;Justice;Latinx;Laws;Legal;Link;Lived experience;Low income;Low Income Population;Measures;Mediating;Mediator;Mental disorders;Mental Health;Methods;Occupational activity of managing finances;Outcome;Participant;Pathway interactions;peer support;Personal Satisfaction;Persons;Policies;Population;Poverty;primary outcome;programs;Provider;racism;Randomized;recidivism;Recording of previous events;Recovery;Research;Research Methodology;Resources;Savings;secondary outcome;Self Efficacy;service providers;Services;skills;Social Network;social stress;Social support;Testing;tool;Training;Work

PROJECT_TITLE: Recovery Finance: Financial health and mental health after incarceration


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cardiovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Nutrition;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: OMAHA

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: Project Narrative Heart problems are the number one cause of pregnancy-related death in the United States and most profoundly affect poor and non-White women. Social health programming can help people lead healthier lives by teaching them about stress management and healthy diets, which can help prevent heart disease later in life. Our research project studies how social health programming for teenagers can empower communities across the United States to overcome barriers to health and reduce the long-term burden of adult heart disease during pregnancy.

PI_NAMEs: DRAKOWSKI, REBECCA ANNE (contact)

PROGRAM_OFFICER_NAME: LINARES, DEBORAH ELIZABETH

PROJECT_TERMS: Address;Adolescence;Adolescent;Adult;adverse childhood events;Affect;after-school program;Age;Antioxidants;Biological Markers;Black race;Blood Vessels;cardiometabolic risk;cardiometabolism;Cardiovascular Diseases;cardiovascular health;cardiovascular risk factor;Cardiovascular system;Carotenoids;Child;Childhood;Clinical;Clinical Markers;Collaborations;Communication;Communities;community empowerment;Community Health;Data;Death Rate;design;Development;dietary;Dietary intake;Dietary Practices;disadvantaged women;Disease;Disparity;Dyslipidemias;Education;Educational process of instructing;Educational workshop;Elasticity;Emotional;empowerment;Endothelium;Enzyme-Linked Immunosorbent Assay;experience;Exposure to;falls;Female Adolescents;food insecurity;Future;girls;Goals;good diet;Grant;Hair;Health;health care availability;health disparity;Healthy Eating;Heart;heart disease prevention;Heart Diseases;high-risk adolescents;Hydrocortisone;Hypertension;improved;Individual;Inflammation;Informal Social Control;innovation;Institutional Racism;Intake;Intervention;Knowledge;Lead;Life;Liquid Chromatography;Literature;maternal morbidity;Maternal Mortality;Measures;Medical center;modifiable risk;mortality;Nebraska;Needs Assessment;Nutrient;nutrition;Nutritional;Nutritional status;Omega-3 Fatty Acids;Outcome;Participant;peer;Persons;Phenotype;Physical activity;Physicians;Poverty;Pregnancy;Pregnancy Complications;Pregnancy Outcome;pregnancy related death;psychologic;Psychological Stress;psychosocial;Psychosocial Assessment and Care;Psychosocial Stress;psychosocial stressors;Public Health;Quality of Care;Questionnaires;Reporting;Research;Research Design;Research Project Grants;resilience;resilience scale;Risk;Risk Factors;Saliva;Schools;Scientist;Self Efficacy;Serum;skills;social;Social outcome;sociodemographic disparity;socioeconomic disadvantage;stress management;Structural Racism;tandem mass spectrometry;Technical Expertise;Teenagers;Testing;therapy design;Time;Training;training opportunity;trend;Unhealthy Diet;United States;Universities;verbal;Vitamin D;Vitamin E;Woman;Writing;Youth

PROJECT_TITLE: SPARKLED: Social Programming Affects Risk in Kids of Latent Endothelial Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F16-L(20)L]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cardiovascular;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurodegenerative;Neurosciences;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: BATON ROUGE

ORG_NAME: LSU PENNINGTON BIOMEDICAL RESEARCH CTR

ORG_STATE: LA

PHR: Narrative African American adults have two times the risk of developing Alzheimer’s Disease compared to other ethnic groups. Regular physical activity is promising for reducing risk of Alzheimer’s Disease, but there is very little data on this question in African Americans. The current study (called “RAATE-MCI”) will determine if regular physical activity conducted over a year will reduce risk factors for developing Alzheimer’s Disease in older African American adults with mild cognitive impairment. We will assess participant’s brain functioning, brain structure, memory, chromosomes, and the contribution of plaques in the brain on outcomes.

PI_NAMEs: CARMICHAEL, OWEN T.;NEWTON, ROBERT LEE (contact)

PROGRAM_OFFICER_NAME: STOECKEL, LUKE

PROJECT_TERMS: active control group;Address;Adult;African American;African American population;Age;Aging;Alzheimer's Disease;Alzheimer's disease risk;Amyloid;Anti-Inflammatory Agents;Biological;Biological Assay;Biological Markers;Blood;Blood Vessels;Brain;brain tissue;Brain-Derived Neurotrophic Factor;cardiorespiratory fitness;cardiovascular risk factor;Cardiovascular system;caucasian American;cerebrovascular;Cerebrovascular Circulation;Cerebrum;Characteristics;Chromosomes;Chronic;Clinical;clinical phenotype;Cognitive;cognitive benefits;cognitive enhancement;cognitive function;cohort;Communities;comparison control;Control Groups;Data;Dementia;depressive symptoms;Development;Diagnosis;Diet;Education;Effectiveness;Elderly;Episodic memory;Ethnic Population;Evaluation;evidence base;Exclusion;executive function;Exercise;exercise intervention;experience;Exposure to;fitness;Functional impairment;Functional Magnetic Resonance Imaging;genetic risk factor;Genotype;gray matter;health disparity;Hormones;Impaired cognition;Impairment;improved;Individual;insight;Insulin-Like Growth Factor I;Intervention;Ischemia;Knowledge;Length;Leukocytes;life span;Magnetic Resonance Imaging;Measurement;Measures;Mediating;Memory;Memory Loss;Mental Depression;mild cognitive impairment;National Institute on Alcohol Abuse and Alcoholism;Nerve Degeneration;Neurobiology;neuroimaging;neuromechanism;neuroprotection;neuropsychiatry;neurotrophic factor;Not Hispanic or Latino;older adult;Other Genetics;Outcome;Participant;Pathway interactions;Patients;Perfusion;Phenotype;Physical activity;Physiological;Population;Positron-Emission Tomography;preservation;Prevalence;prevent;programs;Public Health;Randomized;randomized, clinical trials;Randomized, Controlled Trials;Recommendation;recruit;Research;response;Risk;Risk Factors;Risk Reduction;Sample Size;sex;Sleep;Structure;symptomatology;telomere;Time;trial design;Underserved Population;White Matter Hyperintensity;β-amyloid burden

PROJECT_TITLE: Reducing African Americans' Alzheimer's Disease Risk Through Exercise-MCI Cohort (RAATE-MCI)


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science;Climate-Related Exposures and Conditions;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Effects of Household Energy Combustion;Health Effects of Indoor Air Pollution;Prevention;Social Determinants of Health

ORG_CITY: FORT COLLINS

ORG_NAME: COLORADO STATE UNIVERSITY

PHR: Narrative Exposure to household air pollution from primitive energy sources (such as charcoal and wood-burning stoves and kerosene lamps) is a top-ten risk factor for morbidity and mortality worldwide. This research will investigate whether a whole-house energy intervention can produce meaningful health benefits for women, men, and children in rural Rwandan homes. Outputs from this work will increase the clinical knowledge-base on the health effects on household air pollution and will generate policy-relevant information on scalable solutions to achieving cleaner, healthier forms of household energy.

PI_NAMEs: CLARK, MAGGIE LYNN (contact);VOLCKENS, JOHN

PROGRAM_OFFICER_NAME: THOMPSON, CLAUDIA L

PROJECT_TERMS: Address;Adoption;Adult;Adult women;Africa;aged;American;anthropogenesis;arm;Biomass;Blood Pressure;burden of illness;Carbon Black;Charcoal;Child;climate forcing;Clinical;clinical outcome measures;clinically actionable;Colorado;Communities;Complement;cooking;Cookstove;cost;Costs and Benefits;Country;Data;design;Development;Economics;Eligibility Determination;energy balance;Energy-Generating Resources;Ensure;Exposure to;fine particles;Gases;Goals;Growth;Guidelines;Health;Health Benefit;Heating;Home;Hour;Household;Household Air Pollution;Human;Human Rights;improved;Infrastructure;Intervention;Kerosene;knowledgebase;Lighting;Link;low and middle-income countries;male;Marketing;Measurement;Measures;men;Modeling;Modernization;Morbidity - disease rate;mortality;Natural Gas;Output;Participant;Persons;Petroleum;Planet Earth;Policies;Policy Maker;Population;prevent;Privatization;Provider;public-private partnership;pulmonary function;Randomized;Randomized, Controlled Trials;Readiness;recruit;Research;research study;response;Risk Factors;Rural;rural area;Rural Health;Rwanda;secondary endpoint;Solar Energy;solid fuel;Source;Technology;timeline;treatment arm;Universities;Woman;Wood material;Wood stove;Work;World Health Organization

PROJECT_TITLE: Sustainable Household Energy Adoption in Rwanda (SHEAR): Promoting Rural Health with Solar and Natural Gas

STUDY_SECTION: CIHB

STUDY_SECTION_NAME: Community Influences on Health Behavior Study Section[CIHB]


ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: Project Narrative Our training program in “Diseases of Public Health Importance” aims to provide interdisciplinary training in basic sciences related to the etiology, pathogenesis, prevention, and cure of diseases with significant global impact. The ultimate goal is to equip our future basic scientists with the tools to combat infectious disease challenges so that they can work to find creative solutions to lessen the global burden of disease through innovative research.

PI_NAMEs: LUND, JENNIFER M (contact)

PROGRAM_OFFICER_NAME: SASTALLA, INKA I

PROJECT_TERMS: Disease;Grant;Public Health;Training

PROJECT_TITLE: Diseases of Public Health Importance Training Grant

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases B Research Study Section[MID-B]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Eye Disease and Disorders of Vision;Genetics;Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: CLEVELAND

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

PHR: Project Narrative.  Mutations in the photoreceptor-specific TULP1 gene cause an early-onset and severe form of retinitis pigmentosa, an inherited form of blindness. The first goal of this research project is to identify the function of Tulp1 and determine the complement of proteins comprising the Tulp1 complex and how these interactions combine to assemble the machinery required to transport photoreceptor proteins. The second goal is to define the pathological mechanism causing photoreceptor degeneration due to TULP1 mutations thereby identifying pathways as specific targets for therapeutic intervention aimed at slowing this blinding condition.

PI_NAMEs: HAGSTROM, STEPHANIE A (contact)

PROGRAM_OFFICER_NAME: NEUHOLD, LISA

PROJECT_TERMS: Adaptor Signaling Protein;Affect;Autophagocytosis;autosome;Binding;Binding Proteins;biological adaptation to stress;Biological Assay;Biology;Blindness;C-terminal;Carrier Proteins;Cell Death;Cell Line;Cell Physiology;Cells;Chronic;Co-Immunoprecipitations;Complement;Complex;CRISPR/Cas technology;crosslink;Data;Defect;Degradation Pathway;Disease;Disease Progression;early onset;endoplasmic reticulum stress;experimental study;Fluorescence Resonance Energy Transfer;Gene Dosage;Genes;Goals;Golgi Apparatus;high resolution imaging;Histology;Human;Immunohistochemistry;Immunoprecipitation;In Situ Nick-End Labeling;In Vitro;in vivo;Inherited;Knock-in;Knock-in Mouse;KRP protein;Leber's amaurosis;link protein;Lipid Binding;Location;malformation;Maps;Mass Spectrum Analysis;Mediating;Membrane;Methods;microtubule-associated protein 1B;Missense Mutation;Modeling;Molecular;molecular marker;Molecular Profiling;mouse model;Movement;multicatalytic endopeptidase complex;Mus;mutant;Mutation;N-terminal;Neurotransmitters;novel;Pathogenicity;Pathologic;Pathway interactions;Patients;Phenotype;Phospholipids;photoreceptor degeneration;Photoreceptors;Phototransduction;Process;Protein Binding Domain;Protein Biosynthesis;protein degradation;protein protein interaction;protein transport;Proteins;Proteomics;proteostasis;Quantitative Reverse Transcriptase PCR;recruit;Reporter;Reporter Genes;Research Project Grants;response;Retina;Retinal Degeneration;Retinitis Pigmentosa;ribbon synapse;scaffold;Site;spatiotemporal;superresolution imaging;Synapses;targeted treatment;Testing;Therapeutic Intervention;therapeutic target;Time;trafficking;Transgenic Mice;Ubiquitin;Vesicle;vesicle transport;Vesicular Transport Proteins;Work

PROJECT_TITLE: Molecular Mechanisms of TULP1-Mediated Photoreceptor Degeneration

STUDY_SECTION: BDE

STUDY_SECTION_NAME: Biology and Development of the Eye Study Section[BDE]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Nutrition

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: NARRATIVE This study focuses on cellular networks in the Alzheimer’s disease brain. Our studies take a GeroScience approach and are guided by our prior studies of the biology of the aging brain. We test whether delayed aging and neuroprotection by caloric restriction can ameliorate pathology advance in Alzheimer’s disease mice, focusing on the metabolic microenvironment and communication among neuronal and vascular networks.

PI_NAMEs: ANDERSON, ROZALYN M. (contact)

PROGRAM_OFFICER_NAME: FU, YI-PING

PROJECT_TERMS: Affect;Age;age related;age-related disease;Aging;aging brain;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease pathology;anti aging;Astrocytes;astrogliosis;Attenuated;Behavior;behavior test;Biology;Biology of Aging;Blood flow;Blood Vessels;Brain;brain cell;brain metabolism;brain volume;burden of illness;Caloric Restriction;Cell Communication;Cells;Clinical;Coculture Techniques;Communication;Coupled;cranium;density;Detection;Development;Disease;Disease Progression;effective therapy;Electrodes;Electrophysiology (science);Energy Metabolism;Environment;Etiology;experimental study;Gene Expression;genetic approach;Geroscience;Hippocampus;Histocytochemistry;Image;imaging study;Imaging technology;Impaired cognition;Implant;in vivo;in vivo imaging;Individual;insight;Intervention;live cell imaging;Measures;Memory;Metabolic;metabolic imaging;Metabolism;microscopic imaging;Mitochondria;Modeling;Monkeys;Morphology;mouse model;Mus;Neurofibrillary Tangles;Neuroglia;Neurons;neuroprotection;optogenetics;Outcome;Oxidation-Reduction;patch clamp;Pathology;Pattern;pharmacologic;Play;preservation;Prevalence;Proteomics;Research;response;Role;Senile Plaques;Signal Transduction;Synapses;Synaptic Transmission;System;tau-1;Tauopathies;Techniques;Testing;Therapeutic;Time;Tissues;tomography;Translating;trend;two-photon;United States;Work

PROJECT_TITLE: Metabolism of Alzheimer’s Disease: systems and cellular networks


ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Microbiome;Pediatric;Social Determinants of Health;Women's Health Research

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIV NEW YORK MORNINGSIDE

ORG_STATE: NY

PHR: PROJECT NARRATIVE  This project—the FFG3 study—will collect data on the 3rd generation of the Fragile Families and Child Wellbeing Study (FF). We will collect information on perinatal health, parenthood experiences, and characteristics of households and families into which the 3rd-generation children are born, as well as biological samples from the 3rd-generation children and their parents who are not already part of the FF study. The data will facilitate novel and important analyses of intergenerational transmission of health, intergenerational relationships within families, and gene*environment effects on health.

PI_NAMEs: NOTTERMAN, DANIEL A.;REICHMAN, NANCY E;TEITLER, JULIEN O (contact)

PROGRAM_OFFICER_NAME: JEKIELEK, SUSAN

PROJECT_TERMS: Adolescent;Adopted;Adoption;Adult;Affect;Behavior;Biological;Biological Factors;Birth;Characteristics;Child;Child Rearing;Child Welfare;cohort;Cohort Studies;Competence;Data;Data Collection;Data Set;Development;DNA;DNA Methylation;Economics;Enrollment;Environmental Risk Factor;Epigenetic Process;experience;Family;Fathers;fecal microbiome;Female;Foundations;Future;gene environment interaction;Generations;Genes;Genetic;Genotype;Health;health disparity;Household;Household and Family;Immune;Immune system;Inequality;infancy;intergenerational;Investigation;kindergarten;Length;Life Cycle Stages;Living Arrangement;male;Measures;metagenomic sequencing;microbiome;middle childhood;Mothers;Neonatal;novel;Parents;Pattern;Perinatal;perinatal health;Physical environment;Postpartum Period;Poverty;Pregnancy;prenatal;prepregnancy;Probability Samples;Process;psychologic;Readiness;recruit;Reporting;resilience;Ribosomal RNA;Running;saliva sample;same-sex partnership;Sampling;Schools;Shapes;Siblings;Social Environment;social factors;sociodemographics;stool sample;success;Surveys;telomere;Time;transition to adulthood;transmission process

PROJECT_TITLE: Fragile Families: The Third Generation

STUDY_SECTION: SSPA

STUDY_SECTION_NAME: Social Sciences and Population Studies A Study Section[SSPA]