NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Dementia;Neurodegenerative;Neurosciences;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: BIRMINGHAM

ORG_DEPT: PATHOLOGY

PHR: Project Narrative Aging is a major risk factor for dementia, which is a particularly devastating disease in older people, yet we still do not fully understand the mechanisms behind this. Current treatments for dementia are inadequate for people of all ages. My proposed research will determine how mitochondria and inflammation in blood vessels in the brain enhance cognitive decline with the goal of improving treatment for dementia and related diseases in blood vessels of the brain.

PI_NAMEs: TYRRELL, DANIEL  (contact)

PROGRAM_OFFICER_NAME: BARRETT, PAUL JOHN

PROJECT_TERMS: Age;age related;aged;Aging;Alzheimer's Disease;Alzheimer’s disease biomarker;Bilateral;Blood - brain barrier anatomy;Blood brain barrier dysfunction;blood damage;Blood Vessels;blood-brain barrier function;Brain;career;Carotid Stenosis;cell type;cerebral hypoperfusion;cerebrovascular;Cerebrovascular Circulation;Cerebrovascular Disorders;Cerebrovascular system;Cerebrum;cognitive enhancement;cognitive function;conditional knockout;Coupled;Data;Dementia;dementia risk;Disease;Excision;Exhibits;experience;Faculty;formyl peptide;FPR1 gene;Genetic;genetic approach;Glucose;Goals;Health;Human;human old age (65+);Impaired cognition;Impairment;improved;Inflammation;Inflammatory;Interleukin 6 Receptor;Interleukin-6;ischemic injury;Knockout Mice;Knowledge;Mediating;member;Mentors;Michigan;Mitochondria;mitochondrial dysfunction;Modeling;Molecular;mouse model;Mus;Nerve Degeneration;Neurobiology;normal aging;novel;old mice;older adult;Older Population;Oxidative Phosphorylation;Oxygen;Parkin;pathological aging;Pathology;Pathway interactions;Pattern;Persons;pharmacologic;Positioning Attribute;preservation;Prevalence;Proteins;Reporter;Research;Research Personnel;Research Proposals;Risk;Rotenone;skills;Specimen;Spermidine;Testing;Training;Transgenic Mice;vascular cognitive impairment and dementia;Vascular Dementia;Vascular Diseases;young adult

PROJECT_TITLE: Cerebrovascular Mitochondrial Function in Aging and Ischemic Injury


ADMINISTERING_IC: MH

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Precision Medicine;Prevention

ORG_CITY: CHARLOTTESVILLE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: NEUROLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Project Narrative  Current gold-standard diagnostic techniques for Autism Spectrum Disorder rely on behavioral observation, and diagnosis is often not conferred until after age 4. This delay is unfortunate, because early intervention can drastically improve outcomes. This proposal seeks to identify and validate early-emerging neurobiological markers of ASD that occur before behavioral symptoms manifest to serve as diagnostic, risk, and/or treatment response biomarkers of social dysfunction in ASD.

PI_NAMEs: PUGLIA, MEGHAN H (contact)

PROGRAM_OFFICER_NAME: BECHTHOLT, ANITA JEAN

PROJECT_TERMS: Adolescent;Adult;Age;Age Months;aged;Algorithms;Architecture;autism biomarker;autism spectrum disorder;autism symptoms;autistic;autistic behaviour;autistic children;Behavior;behavior observation;Behavioral;Behavioral Symptoms;Biological Markers;biomarker development;biotypes;Brain;Caliber;career;Child;Child Health;Classification;Clinical;Clinical Trials;cognitive ability;cognitive development;cognitive neuroscience;cognitive performance;cohort;Collaborations;Coupling;Data;Data Science;Data Set;Dedications;Development;Diagnosis;Diagnostic;Diagnostic Procedure;Dimensions;Disease;DNA Methylation;Early identification;Early Intervention;effective intervention;Electroencephalography;Enrollment;Entropy;Environment;epigenetic marker;Epigenetic Process;epigenome;Foundations;Genetic;Goals;Heterogeneity;improved outcome;Individual Differences;individualized medicine;Infant;large scale data;Lead;Life;Link;longitudinal dataset;Longitudinal Studies;Measures;Mentors;Modeling;Nature;neural;neural network;Neurobiology;Neurocognitive;neurodevelopment;neurophysiology;Neurosciences;Noise;novel marker;Outcome;Oxytocin;Oxytocin Receptor;Pathway interactions;Play;precision medicine;Prediction of Response to Therapy;Predictive Analytics;Premature Infant;programs;public health priorities;Receptor Gene;Research;response biomarker;Rest;Risk;Role;Sampling;Sensitivity and Specificity;Series;sex;Signal Transduction;Signs and Symptoms;Social Behavior;social deficits;Social Perception;Stratification;Testing;Time;Training;Treatment outcome;treatment planning;treatment response;Universities;Virginia;Work

PROJECT_TITLE: Temperodynamic neural variability as an early-emerging biomarker of autism spectrum disorders

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


ADMINISTERING_IC: HD

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Pain Research;Pediatric;Physical Activity;Physical Injury - Accidents and Adverse Effects;Prevention;Rehabilitation;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury;Unintentional Childhood Injury

ORG_CITY: SEATTLE

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

ORG_STATE: WA

PHR: PROJECT NARRATIVE A significant number of youth experience concussive symptoms lasting greater than one month (Persistent Post-Concussive Symptoms, PPCS), and there is scant research to guide treatment. This study will definitively determine the efficacy of a smartphone-delivered rehabilitative exercise intervention for treating PPCS in youth, examine long-term effects on health-related quality of life, and explore a novel potential mediator, Fear- avoidance.

PI_NAMEs: CHRISMAN, SARA P.D. (contact)

PROGRAM_OFFICER_NAME: MARDEN, SUSAN F

PROJECT_TERMS: 18 year old;Accelerometer;acceptability and feasibility;actigraphy;Affect;Age;arm;attentional control;barrier to care;Behavior;biopsychosocial factor;Brain Concussion;Caring;Cellular Phone;Cerebrum;Charge;Childhood;chronic pain;Clinical;Cognitive;cognitive function;comparison control;Complex;concussive symptom;Consensus;Data;Disabling;Dizziness;efficacy evaluation;Equipment and supply inventories;Exercise;exercise intervention;exercise program;exercise rehabilitation;Exercise Therapy;experience;experimental group;Family;fitbit;Fright;functional improvement;geographic barrier;Growth;Guidelines;Headache;Health;health related quality of life;Heart Rate;Hip region structure;Home;Improve Access;improved;Individual;innovation;Intention;Intervention;intervention effect;Long-Term Effects;Measures;Mediating;Mediation;Mediator;Methods;mHealth;Modeling;moderate-to-vigorous physical activity;novel;Outcome;Pain;parental influence;parental role;Patients;Perfusion;Persons;Physical activity;Physiological;Physiological Processes;Pilot Projects;Post-Concussion Syndrome;primary outcome;Process;programs;protective behavior;psychologic;Publishing;Quality of life;Questionnaires;Randomized;Randomized, Controlled Trials;Recommendation;Recovery;recruit;reduce symptoms;Research;Research Training;response;Rest;secondary outcome;Series;sex;Shapes;Site;Social Development;social relationships;Specialist;Standardization;stem;Stretching;success;Surveys;symposium;Symptoms;Testing;theories;Time;Training;Transcend;treatment arm;treatment as usual;treatment effect;Videoconferencing;Visit;Work;Youth

PROJECT_TITLE: Mobile Subthreshold Exercise Program for Concussion (M-STEP)

STUDY_SECTION: BMIO

STUDY_SECTION_NAME: Behavioral Medicine, Interventions and Outcomes Study Section[BMIO]


ADMINISTERING_IC: DK

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Assistive Technology;Autoimmune Disease;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Diabetes;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Nutrition;Physical Activity;Prevention

ORG_CITY: CHICAGO

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: ILLINOIS INSTITUTE OF TECHNOLOGY

ORG_STATE: IL

PHR: One out of every 11 people have diabetes and about 10% of them administer insulin for blood glucose regulation. Automated insulin delivery is an advanced treatment to reduce the burden of managing glucose regulation. New wearable devices enabled streaming physiological information of a person. Multivariable automated insulin delivery integrated with artificial intelligence leverages physiological and glucose information, and provides a well-integrated user-friendly technology with minimal burden on the user.

PI_NAMEs: CINAR, ALI  (contact)

PROGRAM_OFFICER_NAME: ARREAZA-RUBIN, GUILLERMO

PROJECT_TERMS: Accelerometer;Activities of Daily Living;Acute;Affect;Algorithms;Artificial Endocrine Pancreas;Artificial Intelligence;Artificial Pancreas;Behavior;Blood Glucose;blood glucose regulation;care providers;Clinical;Clinical Research;Compensation;Complex;complex data;Continuous Glucose Monitor;Data;Data Analyses;Data Reporting;Decision Making;Diabetes Mellitus;Dose;Engineering;euglycemia;Event;Exercise;experimental study;explainable machine learning;Foundations;Fright;Future;Generations;Glucose;glycemic control;Goals;Habits;hands-on learning;human-in-the-loop;Hybrids;Hypoglycemia;improved;Individual;Insulin;Insulin Infusion Systems;Insulin-Dependent Diabetes Mellitus;Learning;Length;Life;Machine Learning;Manuals;Medical;Metabolic;Modeling;Modification;monitoring device;National Institute of Diabetes and Digestive and Kidney Diseases;next generation;novel;Patients;Pattern;Performance;Personal Behavior;Persons;Physical activity;Physiological;Play;prototype;Psychological Stress;Pump;Regulation;Reporting;Research;Resources;response;Role;sedentary;sensor;simulation;Sleep;Sleep disturbances;Source;Stream;Stress;success;System;Techniques;Technology;Time;trend;Update;user-friendly;Variant;wearable data;wearable device;wearable sensor technology;Work;wristband

PROJECT_TITLE: SCH: Integrating AI and System Engineering for Glucose Regulation in Diabetes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-VH-N(50)R]


ADMINISTERING_IC: GM

ED_INST_TYPE: GRADUATE SCHOOLS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics

ORG_CITY: BERKELEY

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

ORG_STATE: CA

PHR: Project Narrative  Our lab is dedicated to the mechanistic understanding of macromolecular function through the visualization of structure, dynamics, and regulatory interactions using cryo-EM, complemented with biochemical and biophysical assays. Our areas of study are centered on the characterization of the regulatory molecular mechanisms governing the function of microtubules and of human transcription/epigenetic complexes.

PI_NAMEs: NOGALES, EVA  (contact)

PROGRAM_OFFICER_NAME: FLICKER, PAULA F

PROJECT_TERMS: Acetylation;analog;Area;Binding;Biochemical;Biological Assay;Biophysics;Cell Differentiation process;Cell Nucleus;Cells;cellular development;Chromatin;chromatin remodeling;cofactor;Complex;Coupling;Cryoelectron Microscopy;Dedications;dimer;Dinucleosome;DNA;Epigenetic Process;Eukaryotic Cell;Funding;Gene Expression;Gene Expression Regulation;Genes;Genetic Transcription;Goals;Growth;Guanosine Triphosphate;Health;Histone H3;histone modification;HTATIP gene;Human;Hydrolysis;Knowledge;Lysine;Methylation;Microtubules;Molecular;Molecular Conformation;mutant;Nucleosomes;Phase;Polycomb;Polymers;PRC1 Protein;Preparation;Process;promoter;Property;Regulation;RNA;RNA Polymerase II;Role;SAGA;Structure;System;TAF1 gene;Techniques;tool;Transcription Coactivator;Transcription Factor TFIIA;Transcription Factor TFIIB;transcription factor TFIIE;transcription factor TFIIF;transcription factor TFIIH;Transcriptional Regulation;Tubulin;Visualization;Work;Yeasts

PROJECT_TITLE: Structural studies of function and regulation of microtubules and transcriptional gene expression machinery


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: CLEVELAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

ORG_STATE: OH

PHR: NARRATIVE Cisplatin chemotherapy is standard care for many cancers but is toxic to the kidneys, though the basis for this toxicity remains unclear to this day. We have recently developed a genetically engineered APE2 mouse model that affords a clearer understanding of this unwanted toxicity, and we will use this knowledge to guide future drug development aimed at reducing, or even entirely avoiding, cisplatin-induced acute kidney injury.

PI_NAMEs: ZHAO, JIANJUN  (contact)

PROGRAM_OFFICER_NAME: WATSON, JOANNA M

PROJECT_TERMS: Acceleration;Actins;Acute Renal Failure with Renal Papillary Necrosis;Address;adduct;Affect;Antisense Oligonucleotides;Attenuated;Base Excision Repairs;Binding;Binding Sites;Biopsy Specimen;Cancer Model;Cancer Patient;Cell Death;Cell Nucleus;Cells;chemotherapy;Cisplatin;Clinical;Clinical Trials;clinically relevant;Credentialing;crosslink;cytotoxic;Data;deafness;design;Development;Disease;DNA;DNA Adducts;DNA Damage;DNA Repair Gene;Dose;drug development;Drug usage;endonuclease;Engineering;Etiology;Event;experimental study;Functional disorder;Future;Genetic Engineering;Genetic Transcription;Genetically Engineered Mouse;Genomics;Glomerular Filtration Rate;glomerulosclerosis;Heart;high throughput screening;homologous recombination;Human;Hyperuricemia;Hypokalemia;in vivo;Inflammatory;inhibitor;Injury to Kidney;innovation;interest;Ischemia;Kidney;knock-down;Knockout Mice;Knowledge;KRASG12D;Malignant neoplasm of lung;Malignant Neoplasms;Maps;Mediating;Mediator;Metabolism;Minor;Mitochondria;Mitochondrial DNA;Modeling;Molecular;mouse model;Mus;Mutation;Myosin Heavy Chains;Nature;neoplastic cell;Nephritis;nephrogenesis;nephrotoxicity;new therapeutic target;novel;Nucleotide Excision Repair;Oxidative Stress;Oxygen Consumption;Pathogenesis;Pathologic;Pathology;Pathway interactions;Patients;Phenotype;Polymerase;prevent;Prevention therapy;Preventive;prophylactic;Prophylactic treatment;Proteins;renal damage;Renal function;repair enzyme;repaired;Research Project Grants;response;Rest;Role;Sampling;Signal Transduction;small molecule inhibitor;Solid Neoplasm;standard care;Symptoms;targeted treatment;Testing;Time;Tissues;Toxic effect;Transgenic Mice;Transgenic Organisms;Translating;translational model;Translational Research;translational study;Treatment Efficacy;Tubular formation;Tubulointerstitial Nephritis;tumor;Up-Regulation;Withdrawal

PROJECT_TITLE: New mouse model of cisplatin-induced AKI and development of prevention therapy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-N(55)R]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Cystic Fibrosis;Infectious Diseases;Lung;Orphan Drug;Rare Diseases

ORG_CITY: BALTIMORE

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Rapid-growing nontuberculous bacterium Mycobacteroides abscessus is recognized as an emerging pathogen with a rising US incidence for individuals with underlying structural lung conditions such as bronchiectasis, cystic fibrosis, and chronic obstructive pulmonary diseases. While it causes chronic disease that leads to rapid lung function decline, existing treatment options require more than a year of daily treatment with antibiotics of poor efficacy and significant toxicities. Here, our aim is to develop new treatment regimen that is orally administered, safe and potent against M. abscessus.

PI_NAMEs: LAMICHHANE, GYANU  (contact)

PROGRAM_OFFICER_NAME: LAUGHON, BARBARA E

PROJECT_TERMS: Abscess;Acute;antagonist;antibiotic design;Antibiotic Resistance;Antibiotic Therapy;Antibiotics;Bacteria;Bacterial Infections;bactericide;beta-Lactamase;beta-Lactams;Bronchiectasis;C3HeB/FeJ Mouse;Case Study;Chronic;Chronic Disease;Chronic lung disease;Chronic Obstructive Pulmonary Disease;Clinical;Clinical Trials;Companions;Complex;Cystic Fibrosis;cystic fibrosis patients;Data;Disease;disease model;Dose;Drug Combinations;Drug resistance;efficacy evaluation;emerging pathogen;Exhibits;experience;FDA approved;Goals;Growth;Human;improved;In Vitro;Incidence;Individual;Infection;inhibitor;Intake;Knee;Longevity;Lung;Lung Diseases;Lung infections;mouse model;Mus;mutant;Mycobacterium abscessus;Mycobacterium tuberculosis;Nightmare;novel;Oral;Oral Administration;Organism;Outcome;Patients;Peptidyltransferase;Pharmaceutical Preparations;Pre-Clinical Model;Predisposition;preservation;Proliferating;pulmonary function decline;Recommendation;Regimen;Research;Resistance;resistant strain;Route;Safety;synergism;Testing;Time;Toxic effect;Treatment Protocols;Virulent;Work

PROJECT_TITLE: A strategy for new regimens to treat pulmonary Mycobacteroides abscessus infection

STUDY_SECTION: DDR

STUDY_SECTION_NAME: Drug Discovery and Mechanisms of Antimicrobial Resistance Study Section[DDR]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Clinical Research;Genetics;Hematology;Infectious Diseases;Lung;Orphan Drug;Precision Medicine;Rare Diseases;Sepsis

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative Acute respiratory distress syndrome (ARDS) is a common cause of respiratory failure in sepsis with a high morbidity and mortality with no effective pharmacologic therapy. We have previously identified an association between ABO blood type, a genetically determined trait characterized by carbohydrate modifications on multiple cells and glycoproteins, and ARDS risk in sepsis. The aim of this research is to determine the association of ABO blood type with sepsis and sepsis-associated ARDS mortality, to develop a tool to identify those most likely to respond to therapies targeting ABO modified proteins, and determine the physiologic effects of blood type on the injury lung in an ex vivo lung perfusion system.

PI_NAMEs: REILLY, JOHN PATRICK (contact)

PROGRAM_OFFICER_NAME: ZHOU, GUOFEI

PROJECT_TERMS: Acute Respiratory Distress Syndrome;ADAMTS;Admission activity;Airway Resistance;Alveolar;Antigens;Attenuated;Biological;Biology;Blood;Blood capillaries;Blood Coagulation Disorders;Blood Platelets;Blood Vessels;Carbohydrates;Cells;Clinical;Clinical Data;Clinical Trials;Coagulation Process;cohort;Collaborations;Critical Care;Critical Illness;Data;Diagnostic tests;Disease;Disseminated Intravascular Coagulation;Dose;Endothelial Cells;endothelial dysfunction;Endothelium;Enrollment;Epidemiologist;Erythrocytes;Exhibits;Extravascular Lung Water;Failure;Family;Functional disorder;Future;Genes;Genetic Variation;Genotype;Glycoproteins;glycosyltransferase;Goals;Heterogeneity;high risk;Human;Hypoxia;improved outcome;injured;Injury;injury recovery;innovation;Knowledge;Lung;lung injury;Measures;Mediating;Modeling;Modification;Molecular;Morbidity - disease rate;mortality;multidisciplinary;Myocardial Infarction;new therapeutic target;patient population;patient subsets;Patients;Pattern;Perfusion;Permeability;pharmacologic;Pharmacotherapy;Phenotype;Physiological;Plasma;Polysaccharides;Population;Precision therapeutics;predictive modeling;predictive tools;prevent;Prior Therapy;prospective;Prospective, cohort study;Proteins;Publishing;Pulmonary Inflammation;Pulmonary Vascular Resistance;Recombinants;Recording of previous events;Reproducibility;Research;Research Personnel;Resources;Respiratory Failure;response;Risk;Risk Estimate;Sepsis;sepsis induced ARDS;septic;septic patients;Subgroup;Syndrome;System;targeted treatment;Testing;Thrombomodulin;Thrombosis;tool;trait;Transferase;Translating;translational genetics;translational scientist;Transplantation;Validation;venous thromboembolism;von Willebrand Factor;Work

PROJECT_TITLE: An ABO Blood Type Defined ARDS Endotype in Sepsis

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Mental Health;Pediatric;Prevention;Social Determinants of Health

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

PHR: Long-acting, injectable Cabotegravir (LAI CAB) HIV pre-exposure prophylaxis (PrEP) has the potential to prevent HIV among those who experience barriers to effective use of daily, oral PrEP, including many adolescents and young adults (AYA) in sub-Saharan Africa who remain at highest risk of HIV incidence. Disappointing, inequitable outcomes from the initial roll-out of oral PrEP globally and limited utilization of promising injectable formulations in other disease areas demonstrate that implementation success is far from certain, however. This study will identify LAI CAB health system implementation opportunities, measure HCW and AYA implementation preferences, identify preference heterogeneity, and specify implementation strategies to optimize LAI CAB impact in Zambia and globally.

PI_NAMEs: BERES, LAURA  (contact)

PROGRAM_OFFICER_NAME: SENN, THERESA ELAINE

PROJECT_TERMS: Adherence;Adolescent and Young Adult;Affective;Africa South of the Sahara;aged;AIDS prevention;Area;career;career development;Characteristics;cis-female;cis-male;Clinical Trials;Cognitive;Collaborations;Competence;Contraceptive methods;Country;Data;Data Collection;Development;Disease;Educational Status;Educational workshop;Effectiveness;Ensure;Equity;evidence base;experience;experimental study;Exploration, Preparation, Implementation, and Sustainment;Formulation;Future;Goals;Guidelines;Health;health care delivery;Health care facility;Health Personnel;Health system;Heterogeneity;high risk;high risk population;HIV;HIV Infections;HIV risk;implementation evaluation;implementation facilitation;implementation science;implementation strategy;improved;Incidence;Individual;Infectious Diseases Research;Injectable;innovation;Institution;International;Internet;Intervention;Knowledge;Low income;Maps;Measures;men;Mentored Research Scientist Development Award;Mentors;Methods;novel;Oral;Outcome;outcome disparities;Perception;Policies;Population;population based;pre-exposure prophylaxis;preference;Prevalence;prevent;Prevention;preventive intervention;Process;Productivity;programs;Protocols documentation;Recommendation;recruit;Regimen;Reporting;Research;research and development;Research Personnel;Resource-limited setting;Risk Assessment;Sampling;Scientist;skills;Specific qualifier value;Stratification;Subgroup;success;Technology;Testing;Time;Training;transgender women;uptake;Woman;women's clinical trial;Zambia

PROJECT_TITLE: Optimizing implementation of long-acting, injectable Cabotegravir for HIV prevention among adolescents and young adults in Zambia

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Bioengineering;Brain Disorders;Cerebrovascular;Clinical Research;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Patient Safety;Prevention;Rural Health;Social Determinants of Health;Stroke

ORG_CITY: HERSHEY

ORG_NAME: PENNSYLVANIA STATE UNIV HERSHEY MED CTR

PHR: Public Health Relevance This R01 application seeks to develop and prospectively and externally validate ensemble machine-learning- based models to predict recurrence and all-cause mortality after an ischemic stroke as a promising novel approach for risk stratification for targeted prevention. The investigators will use data from three large healthcare systems to advance the manner in which large integrated datasets that are readily available in electronic health records can be leveraged for disease management and potentially improve outcomes for stroke patients. Novel findings derived from this project can be readily adapted to other complex conditions.

PI_NAMEs: ABEDI, VIDA  (contact);ZAND, RAMIN

PROGRAM_OFFICER_NAME: JANIS, SCOTT

PROJECT_TERMS: Address;algorithmic bias;Area Under Curve;Artificial Intelligence;burden of illness;Caring;Cause of Death;Cessation of life;Characteristics;Clinical;Clinical Data;cohort;Communities;Complex;Creativeness;Data;Data Element;data harmonization;data integration;data modeling;data quality;Data Set;Death Rate;density;design;disability;Discrimination;Disease Management;electronic health data;Electronic Health Record;Evaluation;experience;Foundations;Health;Health system;Healthcare;Healthcare Systems;high risk;implicit bias;improved;improved outcome;Individual;insight;Ischemic Stroke;Low Income Population;machine learning model;machine learning prediction;Measures;model development;Modeling;mortality;mortality risk;Multicenter Studies;novel;novel strategies;Output;Patient Care;Patients;Pennsylvania;Performance;Persons;Population;post stroke;predictive modeling;Predictive Value;Prevention;prognostic model;prospective;public health relevance;Publishing;Race;Recurrence;Registries;Reporting;Research;Research Personnel;Resource Allocation;Resources;Risk;risk stratification;role model;Rural;rural area;Sample Size;Screening procedure;Secondary Prevention;sex;social health determinants;Specificity;Standardization;Stroke;stroke model;stroke patient;Subgroup;Time;trait;trend;urban area;Validation;Variant

PROJECT_TITLE: Machine Learning Prediction of 1-Year Mortality and Recurrence after Ischemic Stroke Using Enriched EHR data

STUDY_SECTION: NMBH

STUDY_SECTION_NAME: Neurological, Mental and Behavioral Health Study Section[NMBH]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: HANOVER

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: Phase II COBRE funding will strengthen and enhance the Dartmouth Institute for Biomolecular Targeting, which supports innovative strategies to enhance understanding of biological mechanisms and translation of that knowledge into clinical practice. The Institute will continue to catalyze the development of new therapeutic approaches to address cancer, respiratory infections, and other diseases. It also provides unique resources to investigators at Dartmouth and our IDeA partners, enhancing research productivity and funding competitiveness across the region.

PI_NAMEs: MADDEN, DEAN R (contact)

PROGRAM_OFFICER_NAME: CUPIT, PAULINE

PROJECT_TERMS: 2019-nCoV;Acceleration;Address;Antibodies;Area;Autophagocytosis;Award;Awareness;Binding;Biological;Businesses;career;Career Mobility;Centers of Research Excellence;clinical practice;cohort;Communities;community building;Complex;Consultations;Core Facility;cost;Cryoelectron Microscopy;Cystic Fibrosis;Dedications;Development;Diabetes Mellitus;Disease;Disparate;diversity and inclusion;drug development;Drug Targeting;experience;Extramural Activities;Faculty;Faculty Recruitment;faculty research;faculty support;fascinate;Financial Support;forging;Fostering;Foundations;fundamental research;Funding;Future;Generations;Goals;Grant;Home;Image;Immunologics;Infection;Infrastructure;innovation;Institution;instrument;instrumentation;interest;Investigation;Investments;Ion Channel;knowledge translation;Malignant Neoplasms;Mass Spectrum Analysis;member;Membrane Fusion;Mentors;Metabolic Control;Microscope;Microscopy;mid-career faculty;Modeling;Molecular;molecular imaging;Molecular Target;Neoplasm Metastasis;new technology;novel therapeutic intervention;operation;Pathology;Phase;Play;Postdoctoral Fellow;pre-clinical;preclinical development;Production;Productivity;Program Reviews;programs;Protein Biochemistry;protein expression;Proteins;Recovery;recruit;Research;Research Institute;Research Personnel;Research Project Grants;Resources;Respiratory Tract Infections;Role;Schools;Scientist;Seasons;Series;Services;Signal Transduction;Subgroup;success;symposium;Targeted Research;Teacher Professional Development;Technology;Testing;Therapeutic;therapeutic target;Time;tool;translational goal;Translations;tumor progression;Vaccines;Virus Diseases;Work

PROJECT_TITLE: The Institute for Biomolecular Targeting


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding

PROJECT_TERMS: Acceleration;Address;Administrative Efficiency;Advisory Committees;Award;Basic Science;Biological Sciences;career development;Centers of Research Excellence;Collaborations;Communication;Communities;community building;Complex;conflict resolution;Core Facility;Creativeness;Curiosities;Data;Development;Disease;Doctor of Philosophy;Education;Education and Outreach;Educational Activities;Educational workshop;Ensure;Environment;Evaluation;Expenditure;experience;Extramural Activities;Faculty;faculty mentor;forging;Fostering;Foundations;Funding;Goals;Growth;high standard;Individual;innovation;Institution;Institutionalization;International;Internet;Investigation;Leadership;Malignant Neoplasms;meetings;member;Mentors;Mission;Monitor;novel;peer;Performance;Phase;Pilot Projects;preclinical development;Probability;Process;Productivity;Program Evaluation;programs;Progress Reports;Public Health;recruit;Reporting;Research;Research Activity;Research Infrastructure;Research Personnel;Research Project Grants;Research Support;Resources;Respiratory Tract Infections;Schedule;Series;Services;skills;social media;Structure;success;Sum;symposium;System;Targeted Research;Technology Transfer;tenure track;Translational Research;United States National Institutes of Health;Validation;web site

PROJECT_TITLE: Research Administration and Mentoring Core


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Dental, Oral, and Craniofacial Disease;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Maternal Health;Maternal Morbidity and Mortality;Prevention;Primary Health Care;Social Determinants of Health;Women's Health Research

ORG_CITY: GAINESVILLE

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE Oral health during pregnancy and postpartum has significant impact on a woman’s overall health, birth outcomes and their child’s oral health. This study will provide evidence on how the generosity of state Medicaid dental benefits during pregnancy and postpartum impacts access to routine and emergent dental care. Understanding the effects of dental benefits generosity and duration is critical to inform policy decision-making and implementation of recent expansions of Medicaid dental benefits for pregnant and postpartum women aimed to improve maternal health outcomes.

PI_NAMEs: SINGHAL, ASTHA  (contact)

PROGRAM_OFFICER_NAME: IIDA, HIROKO

PROJECT_TERMS: Accident and Emergency department;administrative database;Adoption;American;Appointment;Birth;Child;cost;Data;Data Files;Decision Making;Dental;Dental Care;Dentists;Disparity;Eligibility Determination;Emergency department visit;Emergency Situation;Enrollment;federal policy;Future;Goals;Health;Healthcare;Home;improved;Information Systems;insight;Knowledge;life span;Low Birth Weight Infant;Low income;Maternal Health;Measures;Medicaid;Medicaid eligibility;Medical;Monitor;Mothers;novel;Oral;Oral health;Outcome;Parents;Patient Self-Report;Patients;Pattern;Periodontitis;Physiological;Policies;Policy Making;post implementation;Postpartum Period;Postpartum Women;Pregnancy;pregnant;Pregnant Women;Premature Birth;prenatal;Preventive;Preventive dental care;programs;Qualifying;Quasi-experiment;Research;Research Design;Risk;Risk Assessment;Services;Surveys;Techniques;Time;Tooth Diseases;Tooth Loss;Variant;Visit;Woman

PROJECT_TITLE: Effects of Pregnancy and Postpartum Medicaid Dental Benefit Generosity On Use Of Dental Services

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


NIH_SPENDING_CATS: Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding

PI_NAMEs: MIERKE, DALE F (contact)

PROJECT_TERMS: Acceleration;Affinity;Awareness;Back;base;Binding;Biochemical;Biomedical Research;biophysical properties;Biotechnology;Cell Line;Cells;Centers of Research Excellence;Charge;Cloning;Collaborations;Collection;college;Communities;Complement;Complex;Consultations;cost;Cost Analysis;Cost Sharing;Dedications;design;design and construction;Development;Elements;Enzymes;Equipment;Escherichia coli;Eukaryotic Cell;experience;Faculty;faculty research;Feedback;flexibility;Foundations;Funding;Future;Goals;Grant;Hemagglutinin;Heterogeneity;Histone H3;HLA-A gene;Human;improved;Incubated;Influenza Hemagglutinin;Insecta;instrumentation;Investments;Laboratories;large scale production;Lead;Mammalian Cell;manufacturing scale-up;Measures;Methods;Modeling;Molecular;molecular imaging;Monoclonal Antibodies;mutant;Neoplasm Metastasis;New Hampshire;oncolytic virotherapy;operation;Peptide/MHC Complex;Phase;Pilot Projects;Plant Resins;Play;pressure;Procedures;Production;Productivity;Protein Biochemistry;protein expression;protein purification;Proteins;protocol development;Protocols documentation;quality assurance;Reagent;Recombinants;Recovery;recruit;Research;Research Personnel;Research Project Grants;Resources;Role;Scheme;Scientist;screening;Sequence Analysis;Services;Specificity;Strategic Planning;Structure;success;System;T memory cell;Tail;Techniques;Testing;tool;Training;Universities;vector;Work

PROJECT_TITLE: Molecular Tools Core


NIH_SPENDING_CATS: Genetics;HIV/AIDS;Infectious Diseases

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PI_NAMEs: HULTQUIST, JUDD F (contact);SHILATIFARD, ALI

PROGRAM_OFFICER_NAME: SANDERS, BRIGITTE E

PROJECT_TERMS: Agonist;analog;antiretroviral therapy;Benchmarking;Binding;Biological Assay;Biological Models;Bromodomains and extra-terminal domain inhibitor;C-terminal;Cell Line;Cell model;Cells;Chromatin;Chromatin Remodeling Factor;Collaborations;Complex;Data;design;Development;efficacy testing;Evaluation;experimental study;Genes;Genetic Transcription;Histone Deacetylase Inhibitor;HIV;HIV Infections;HIV tat Protein;HIV-1;HIV/AIDS;immune clearance;Immune Evasion;improved;In Vitro;in vivo;Individual;inhibitor;integration site;knock-down;Lead;lead candidate;Licensing;Maintenance;Modeling;Molecular;Molecular Probes;next generation;novel;novel therapeutics;Patients;Penetrance;Peripheral Blood Mononuclear Cell;Persons;Phosphorylation;Phosphotransferases;Positive Transcriptional Elongation Factor B;prevent;promoter;Protein Kinase C;Provirus Integration;Proviruses;reactivation from latency;recruit;Regimen;Reporting;Repression;research and development;Research Priority;RNA Polymerase II;Role;screening;Series;Shock;Site;small molecule;small molecule inhibitor;Specificity;synergism;T-Lymphocyte;Tail;tat Protein;Testing;Therapeutic;therapeutic development;Transactivation;Transcription Elongation;Transcriptional Regulation;United States National Institutes of Health;Viral;viral rebound;Virus;Withholding Treatment;Work

PROJECT_TITLE: Exploring Small Molecule Inhibitors of PAF1C as Novel HIV Latency Reversal Agents

STUDY_SECTION: HVCD

STUDY_SECTION_NAME: HIV Molecular Virology, Cell Biology, and Drug Development Study Section[HVCD]


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Obesity;Clinical Research;Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: BOSTON

ORG_NAME: NORTHEASTERN UNIVERSITY

ORG_STATE: MA

PHR: PROJECT NARRATIVE The Environmental influences on Child Health Outcomes (ECHO) Program investigates the roles of a broad range of early exposures on five key child health outcomes among diverse populations. In collaboration with the larger ECHO Consortium, the ECHO-PROTECT cohort based in Puerto Rico will contribute data, biological samples, and knowledge that allow us to better understand how these exposures affect child health outcomes both in Puerto Rico and the U.S. mainland. Results from our study will inform future clinical intervention, risk assessment and policy-setting efforts, with direct relevance to both the underserved population of Puerto Rico and the U.S. general population.

PI_NAMEs: ALSHAWABKEH, AKRAM N (contact)

PROGRAM_OFFICER_NAME: PARK, CHRISTINA H

PROJECT_TERMS: Adaptive Behaviors;Adolescence;Affect;anogenital distance;Area;Biological;Biological Markers;Birth;Brain;Chemical Exposure;Chemicals;Child;Child Development;Child Health;Childhood;Clinical;Cognition;cohort;Cohort Studies;Collaborations;Communication;Conceptions;Coupled;Data;Data Element;Development;Diet;Discrimination;early childhood;Education;Emotional;environmental chemical;environmental chemical exposure;Environmental Exposure;epigenomics;experience;Exposure to;feeding;Flame Retardants;follow-up;Future;General Population;girls;Goals;Health;health care availability;Hormones;Household;in utero;Income;Individual;infancy;Infant;Inflammation;innovation;Intervention;Knowledge;Language;Lead;Life;maternal obesity;maternal weight;Measures;Mediating;metabolomics;Metals;middle childhood;Minority Groups;Mission;Modification;mother nutrition;Mothers;Motor;multidisciplinary;Nature;Neighborhoods;neurodevelopment;Obesity;obesity in pregnancy;Occupations;Outcome;Outcome Study;Oxidative Stress;Parabens;Participant;Patient Recruitments;Persons;Pesticides;Phase;Phenols;phthalates;Policies;Poly-fluoroalkyl substances;Population;Population Heterogeneity;Poverty;Pregnancy;Pregnancy Outcome;pregnant;programs;Protocols documentation;Puberty;Public Health;Puerto Rico;Questionnaires;recruit;reproductive;reproductive development;Research;response;Risk Assessment;Role;Sample Size;Sampling;Science;Site;social;social disparities;social health determinants;Statistical Methods;Testing;Underserved Population;Unhealthy Diet;Weight;Weight Gain

PROJECT_TITLE: ECHO-PROTECT Cohort Study Site in Puerto Rico

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-EPH-S(50)R]


NIH_SPENDING_CATS: Asthma;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Mental Health;Neurosciences;Pediatric;Social Determinants of Health

ORG_CITY: SAINT LOUIS

ORG_DEPT: PEDIATRICS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative With this study, we aim to understand the impact of recurrent wheezing illnesses on the neurocognitive development of preschool children with an exploratory aim to understand the impact of pre-natal maternal neuro-psychosocial and inflammatory states on neurocognitive development of preschool children. We also intend to recruit new participants, focus on activities that ensure retention and promote best practices for diversity, equity and inclusion of the research team and all aspects of the study.

PI_NAMEs: RIVERA-SPOLJARIC, KATHERINE  (contact)

PROGRAM_OFFICER_NAME: MASH, CLAY

PROJECT_TERMS: Adrenal Cortex Hormones;Affect;Age;Allergic rhinitis;Asthma;Award;behavior measurement;Behavioral;Brain;Child;Childhood;Chronic;Chronic Disease;Cognition;Cognitive;cohort;Cohort Studies;Communities;Data;Data Analyses;design;Development;Diabetes Mellitus;Disease;early childhood;Educational Activities;Emergency department visit;Emotional;Emotions;Ensure;Environment;Environmental Risk Factor;eosinophil;equity, diversity, and inclusion;experience;Focus Groups;Health;healthcare burden;Heart Diseases;Hospitalization;Hypersensitivity;IL17 gene;IL4 gene;IL5 gene;IL6 gene;infancy;Infant;Infant Development;Inflammatory;inflammatory marker;Inhalation;Interleukin-13;Interview;Language;Length;Linear Models;Measures;Mental Depression;Mental Health;Mothers;Motor;Neonatal;Neurocognitive;Newsletter;Nursery Schools;offspring;Oncology;Parents;Participant;participant retention;Patients;Peripheral;Pharmaceutical Preparations;Physicians;pregnant;prenatal;Preschool Child;Protocols documentation;psychosocial;Publishing;Questionnaires;recruit;Recurrence;Reporting;Research;sample collection;Severity of illness;Sickle Cell;Site;social;Social support;Socioeconomic Status;Steroids;Stress;Structure;success;Surveys;Toddler;Traumatic Brain Injury;United States National Institutes of Health;Visit;Wheezing

PROJECT_TITLE: Childhood Allergy and the NeOnatal Environment in St Louis (CANOE-STL) and the Impact of Wheezing Illnesses on Neurocognitive Development of Preschool Children


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding

PI_NAMEs: HIGGS, HENRY N (contact)

PROJECT_TERMS: Actins;Adopted;Area;Award;Awareness;Binding;Biochemical;Biological Assay;Biology;biophysical properties;biophysical techniques;Calorimetry;cell motility;Cells;cellular imaging;Centers of Research Excellence;Collaborations;Collection;Communities;Consultations;Core Facility;cost;cost effective;Cryoelectron Microscopy;Data;Data Analyses;design;Development;DNA Repair;Drosophila genus;Electron Microscopy;Electron Microscopy Facility;Embryo;Endocytosis;Ensure;Environment;Equipment;Experimental Designs;experimental study;Extramural Activities;Faculty;flexibility;fluorescence microscope;Fluorescence Microscopy;Funding;Goals;Grant;Histone H3;Human;Image;Image Analysis;imaging study;Imaging technology;improved;In Situ;In Vitro;Individual;Influenza Hemagglutinin;Infrastructure;Institution;instrument;instrumentation;interest;intravital imaging;Laboratories;Lead;light microscopy;Location;Mammalian Cell;Mass Spectrum Analysis;Measures;Melanoma Cell;member;method development;Methods;Microscopy;Mission;Modeling;Molecular;molecular imaging;Molecular Structure;Monitor;Monoclonal Antibodies;Norris Cotton Cancer Center;Nuclear;operation;Organelles;Participant;Phase;Pilot Projects;Play;polymerization;Polymers;Population;Positioning Attribute;pressure;Process;Production;Program Reviews;Protein Dynamics;Protein Isoforms;protein purification;Proteins;Proteomics;Recovery;recruit;Research;Research Infrastructure;Research Personnel;Research Project Grants;Resolution;Resources;Role;Scientist;Services;Specialist;Spectrum Analysis;Strategic Planning;Structure;success;superresolution microscopy;Surface Plasmon Resonance;Surveys;T-Lymphocyte;Talents;Techniques;Technology;Time;Titrations;tool;Training;tumor;Validation;Virus;Visualization;Water;Work;Workload

PROJECT_TITLE: Molecular Interactions and Imaging Core


NIH_SPENDING_CATS: Kidney Disease

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: NARRATIVE Loop diuretic resistance in congestive heart failure and chronic kidney disease is mediated in part by expansion of the tissue mass and sodium reabsorption capacity of the distal convoluted tubule (DCT) and cortical collecting duct (CCD), which severely limits the ability of loop diuretics to reduce extracellular fluid volume in these patient populations. Loss of Kir4.1/5.1 potassium channel function in the DCT and CCD in EAST/SeSAME syndrome leads to sodium wasting and low blood pressure, providing genetic validation for the idea that Kir4.1/5.1 is a target for novel classes of diuretics that could circumvent many of the disadvantages of conventional diuretics, especially in the setting of diuretic resistance. The overarching goal of this proposal is to employ medicinal chemistry, molecular pharmacology, and renal physiology to optimize a series of newly discovered small- molecule inhibitors for rigorously validating Kir4.1/5.1 as a novel diuretic target.

PI_NAMEs: DENTON, JEROD S. (contact)

PROGRAM_OFFICER_NAME: KETCHUM, CHRISTIAN J

PROJECT_TERMS: Abdomen;absorption;Affect;American;Amiloride;analog;Animals;basolateral membrane;Binding Proteins;Biological Assay;Biology;biopharmaceutical industry;Cells;Chemicals;Chronic Kidney Failure;chronic liver disease;Clinical;Clinical Treatment;Collection;Congestive Heart Failure;Consensus;cost;Databases;Development;Disadvantaged;Disease;Distal;Distal convoluted renal tubule structure;Diuretics;Dose;Drug Kinetics;drug metabolism;Drug Targeting;Duct (organ) structure;Edema;Effectiveness;efficacy evaluation;efficacy study;Electrophysiology (science);equilibration disorder;experience;Extracellular Fluid;Fluid Balance;follow-up;Freedom;Funding;Genetic;Goals;Grant;Heart failure;high reward;high risk;high throughput screening;Human;Hypertension;Hypertrophy;Hypotension;In Vitro;in vivo;Industry Standard;inhibitor;intraperitoneal;Investigational Drugs;Ion Channel;Ions;Kidney;knowledge translation;Laboratories;lead optimization;Legal patent;Licensing;Life;Limb structure;Liquid substance;Liver Failure;loss of function mutation;Lung;Measures;Mediating;meetings;Metabolic;meter;Molecular;mouse model;Mus;Names;Nephrons;novel;Oral;Paper;patch clamp;patient population;Patients;Pharmaceutical Chemistry;Pharmacologic Substance;Pharmacology;Phenotype;Physiology;Plasma;Plasma Proteins;Positioning Attribute;Potassium;Potassium Channel;pre-clinical;programs;Property;Publishing;Renal function;Resistance;response;Risk;scaffold;Series;Sesame - dietary;SeSAME syndrome;Small Business Innovation Research Grant;small molecule inhibitor;Sodium;Sodium Chloride;Structure of ascending limb of Henle's loop;Symptoms;Testing;thiazide;Thiazide Diuretics;Thick;timeline;Tissue Expansion;Tissues;United States National Institutes of Health;Urine;Validation;wasting;Work

PROJECT_TITLE: Preclinical validation of Kir4.1/5.1 inhibitors for overcoming diuretic resistance

STUDY_SECTION: DMPB

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology B Study Section[DMPB]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Pneumonia and Influenza;Prevention;Vaccine Related

PI_NAMEs: LEE, JIWON  (contact)

PROJECT_TERMS: Adult;Affinity;Affinity Chromatography;Age;Antibodies;Antibody Repertoire;Antibody Response;Antibody titer measurement;Antigens;Automobile Driving;B-cell receptor repertoire sequencing;B-Lymphocytes;base;Binding;Biochemical;Biological Assay;Biophysics;Characteristics;Childhood;Circulation;clinically relevant;Communicable Diseases;Competitive Binding;Data;Databases;design;Engineering;Epidemiology;Epitopes;Exposure to;Future;global health;Goals;Hemagglutinin;High-Throughput Nucleotide Sequencing;Humoral Immunities;Immune response;Immune system;Immunity;Immunoglobulin A;Immunoglobulin G;Immunoglobulins;Immunologics;imprint;Individual;Infant;Influenza;Influenza A virus;Influenza A Virus, H1N1 Subtype;Influenza A Virus, H3N2 Subtype;Influenza B Virus;influenza infection;Influenza vaccination;influenza virus strain;influenza virus vaccine;Knowledge;Longevity;Mass Spectrum Analysis;Measures;Memory;Modeling;Molecular;Monoclonal Antibodies;Mutate;Nature;novel;pathogen;Persons;Population;Property;Protein Engineering;protein purification;Proteomics;Recombinants;Recommendation;Recording of previous events;Sampling;seasonal influenza;Seasons;Seminal;Serology;Serology test;Serum;Shapes;Techniques;Technology;Testing;Time;tool;transcriptomics;universal influenza vaccine;Update;Vaccination;Vaccine Design;vaccine response;Vaccines;Virus

PROJECT_TITLE: Understanding the impact of imprinted serum antibody repertoire on subsequent vaccine responses


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Bioengineering

ORG_CITY: ATLANTA

ORG_DEPT: CHEMISTRY

ORG_NAME: GEORGIA STATE UNIVERSITY

ORG_STATE: GA

PHR: The proposed research will develop a generalizable single-entity method for the crystallization of biomacromolecules with predictive crystal quality. Unprecedented real-time monitoring with electroanalytical and optical techniques will provide quantitative signatures for the active controls of individual crystal formation. Single crystals diffract at true atomic resolution under X-ray and neutron sources will provide unambiguous structure insights to correlate with their physiological functions and roles in diseases.

PI_NAMEs: WANG, GANGLI  (contact)

PROGRAM_OFFICER_NAME: TAYLOR, VERONICA

PROJECT_TITLE: A Single Entity Method for Controlled Nucleation and Crystal Growth

STUDY_SECTION: EBIT

STUDY_SECTION_NAME: Enabling Bioanalytical and Imaging Technologies Study Section[EBIT]


NIH_SPENDING_CATS: Biotechnology;Emerging Infectious Diseases;Genetics;Infectious Diseases;Lung;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: NEW YORK

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: PROJECT NARRATIVE Supplemental to its classic role as macrophage activating protein, the cytokine IFN-γ has emerged as a critical mediator of barrier immunity, mobilizing elaborate transcriptional programs within non-lymphoid tissues to combat infection. However, the functions, molecular activities, and regulatory circuits of the interferon-stimulated genes (ISGs) that serve as the effectors of this response are largely a mystery. Focusing on the human lung epithelium, I develop an experimental pipeline to map a functional genetic interaction network that underpins the ability of IFN-γ to restrict different classes of pathogens while balancing pathological tissue damage.

PI_NAMEs: GAUDET, RYAN GILBERT (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: 3-Dimensional;airway epithelium;Anatomy;Antibacterial Response;arm;Bacterial Infections;bactericide;Biological;Biological Assay;Bordetella pertussis;Buffers;Cell Communication;Cell Lineage;cell type;Cells;cellular imaging;Chlamydophila pneumoniae;Chromosome Mapping;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;combat;combinatorial;Complex;CRISPR screen;cytokine;cytokine release syndrome;Cytokine Signaling;Cytosol;empowerment;Endothelium;Epithelium;Fibroblasts;Frustration;functional outcomes;Future;Gene Combinations;gene function;gene network;gene product;Genes;Genetic;Genetic Screening;Genetic Transcription;genomic locus;Genomics;Goals;Health;Host Defense;Host resistance;Human;Human Genome;human model;human tissue;Image;Immune;Immune response;Immune signaling;Immune system;Immunity;Immunology;immunopathology;Individual;infancy;Infection;innovation;insight;Interferon Type II;Interferons;intestinal epithelium;Intestines;Link;Lung;lung pathogen;Lymphocyte;Macrophage;Maps;Mediating;Mediator;Methods;Microbe;Modeling;Molecular;mutant;Network-based;novel;novel strategies;Organ;Organ Donor;Organoids;Outcome;pathogen;Pathologic;Pathology;Pathway interactions;Pattern;Phenotype;Postdoctoral Fellow;Predisposition;programs;Proteins;Protozoan Infections;response;Role;Shapes;Shelter facility;Signal Transduction;single-cell RNA sequencing;Site;Structure;Structure of parenchyma of lung;synergism;System;Techniques;technology development;therapeutic target;Tissues;Validation;virtual;Virus Diseases;Vision;Work

PROJECT_TITLE: Decoding the Interferome by Mapping Genetic Interactions in Human Tissue


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Infectious Diseases;Orphan Drug;Rare Diseases

ORG_CITY: ROCHESTER

ORG_NAME: OYAGEN, INC.

PHR: PROJECT NARRATIVE This proposal addresses the RFA (PA-22-176) call for assay development and screening of chemical probes or therapeutic agents. The urgent need for novel therapeutic intervention strategies is underscored by what has become regular outbreaks of Ebola virus (EBOV), each threatening a potential pandemic of global proportions. Given the rapid progression of the virus and the vulnerabilities in the immune response, a fast- acting, immune system-independent medical countermeasure is proposed that targets EBOV matrix protein (i.e. VP40) as an essential viral protein to produce infectious viruses. This novel approach for a potent, fast-acting therapeutic that is a selective antagonist of Ebola VP40 and viral particle assembly will enhance survival for infected people in hot zones of an Ebola outbreak. We have published our validated drug discovery assay for compounds that will inhibit the function of EBOV VP40 in viral particle assembly. With this proof-of-concept we seek to identify VP40-selective inhibitors with greater antiviral potency that act through a unique mechanism of action on a single target for preclinical development that will address the current sparse pipeline of Ebola therapeutics.

PI_NAMEs: BENNETT, RYAN P (contact)

PROGRAM_OFFICER_NAME: DAVIS, MINDY I

PROJECT_TERMS: Address;antagonist;Anti-viral Agents;antiviral drug development;Area;assay development;Back;Biogenesis;Biological Assay;biosafety level 4 facility;Cause of Death;Cell Cycle;Cell membrane;cell type;Cell-Mediated Cytolysis;Cells;Characteristics;Chemicals;Communities;Complex;Country;Critical Pathways;Cytoplasm;cytotoxic;cytotoxicity;Democratic Republic of the Congo;Disease Outbreaks;Diversity Library;Dose;drug candidate;drug discovery;Dryness;Ebola;Ebola virus;effective therapy;Evaluation;extracellular vesicles;Filovirus;Future;Genetic Transcription;genetic variant;high-throughput drug screening;Homo;imaging system;Immune response;Immune system;Immune Targeting;Immunize;In Vitro;indexing;Individual;Infection;inhibitor;innovation;Intervention;Lead;Libraries;Life;Link;Location;medical countermeasure;Membrane;membrane assembly;migration;mutant;new outbreak;novel;novel strategies;novel therapeutic intervention;novel therapeutics;pandemic potential;particle;Pathology;Patients;Persons;Pharmaceutical Chemistry;Pharmaceutical Preparations;Plasma Cells;Population;Powder dose form;preclinical development;previous outbreak;Probability;Production;Promega;Property;Protein Binding Domain;protein crosslink;protein protein interaction;Proteins;Publishing;Recording of previous events;Reporter;Research;Risk;sangivamycin;screening;Services;small molecule;small molecule inhibitor;social;Structure;success;Symptoms;targeted treatment;Testing;Texas;Therapeutic;Therapeutic Agents;Transcript;Transfection;Travel;Triage;Vaccination;Viral;Viral Genome;Viral Physiology;Viral Proteins;Virion;Virus;Virus Assembly;Virus Replication;Virus-like particle;World Health Organization;Zaire Ebola virus

PROJECT_TITLE: High throughput screening and drug discovery for antagonists of the Ebola VP40 protein assembly

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DCAI-F(12)]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biotechnology;Brain Disorders;Cerebrovascular;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: CAMBRIDGE

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

PHR: Alzheimer’s Disease (AD) is the sixth leading cause of death, but its treatment has been hindered by a lack of human-based models that can mimic key aspects needed to mimic its pathogenesis and treatment: (1) the non- cell autonomous effects of glial, immune, and blood-brain barrier (BBB) cells on the pathology and (2) a 3D BBB that mimics the permeability and selectivity of the human in vivo BBB. To this end I have recently developed a multi-cellular integrated brain (miBRAIN) immuno-glial-neurovascular unit that includes all of the brain-resident cell types that recapitulates key phenotypic and functional phenotypes of the human brain, with enhanced in vivo-like signatures compared to their monocultured counterparts, that I propose to combine with custom microfluidic devices I invented to create and validate 3D-miBRAIN-Chips towards matching human BBB permeability and selectivity in vitro. I will harness these models to probe the effect of the strongest genetic risk factor for sporadic AD, APOE4, constructing and meticulously screening a diverse “in vitro patient cohort,” rigorously validating the platform with a view to translating the technology for maximal utility as an engine for accelerated therapeutic development for AD and other neurodegenerative diseases.

PI_NAMEs: STANTON, ALICE  (contact)

PROGRAM_OFFICER_NAME: CHAKROBORTY, SHREAYA

PROJECT_TERMS: 3-Dimensional;Acceleration;Address;Advisory Committees;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Amyloid;apolipoprotein E-3;apolipoprotein E-4;Back;Biocompatible Materials;Bioinformatics;Biomimetics;Blood - brain barrier anatomy;Blood Tests;blood-brain barrier permeabilization;Brain;brain cell;brain tissue;Businesses;career;career development;Cause of Death;Cell Line;cell type;Cells;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;Coculture Techniques;cohort;constriction;Consultations;cost;Custom;Data;Development;drug development;drug discovery;Engineering;Feedback;General Population;Genetic;genetic risk factor;Genotype;Goals;Human;Immune;improved;In Vitro;in vivo;induced pluripotent stem cell;Inflammation;Inflammatory;insight;Interview;invention;lipidomics;Lipids;Longitudinal cohort;Marketing;Mediating;Mentors;Microfluidic Microchips;mimetics;Modeling;Neurodegenerative Disorders;Neurologic Effect;Neurons;neurovascular;neurovascular unit;novel;Nutrient;Pathogenesis;Pathologic;Pathology;patient population;patient stratification;Patients;Permeability;Pharmacological Treatment;Phase;Phenotype;Physiological;Positioning Attribute;Postdoctoral Fellow;predictive modeling;programs;Property;Race;Reproducibility;Research Methodology;Resources;response;Risk;screening;self assembly;sex;Stratification;Stream;Structure;tau-1;Technology;technology platform;Testing;Therapeutic;therapeutic development;therapeutically effective;Tissue Model;tool;Training;Translating;Translations;Transport Process;Validation;Vision;Work

PROJECT_TITLE: Engineering Immuno-Glial-Neurovascular 3D-Brain-Chips with a Perfusable BBB for Accelerating Alzheimer’s Disease Drug Discovery and Translation


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Contraception/Reproduction;Genetics;Ovarian Cancer;Rare Diseases;Women's Health Research

PI_NAMEs: LACEFIELD, SONI  (contact)

PROJECT_TERMS: Address;Biological Models;cancer prevention;Cell division;Cell Proliferation;Chromosome Segregation;Chromosomes;cyclin B1;Disease;DNA biosynthesis;egg;Ensure;Etiology;experimental study;Female;Fertilization;Genome;Genomics;Germ Cell Cancers;Germ cell tumor;Germ Cells;Human;Image;In Vitro;Infertility;innovation;Malignant Ovarian Germ Cell Neoplasm;Mammals;MAPK Signaling Pathway Pathway;Meiosis;Messenger RNA;Molecular;Mus;mutant;novel;oocyte maturation;Oogenesis;Ovarian Germ Cell Tumor;prevent;Process;Proteins;Regulation;Research;RNA-Binding Proteins;Role;sperm cell;Spontaneous abortion;Technology;Testing;tool;Translations;transmission process;Trisomy

PROJECT_TITLE: Understanding the role of meiotic misregulation in germ cell tumor formation


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Effects of Indoor Air Pollution;Lung;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Tobacco;Tobacco Smoke and Health

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: Project Narrative We propose an ECHO Cohort Study Site in Houston, Texas that will enhance the geographic and racial/ethnic heterogeneity of the ECHO Consortium in a region with complex exposure profles to strengthen the ability of the ECHO Cohort to address research questions related to children’s enviornmental health disparities. We propose scientific aims related to understanding whether maternal discrimination modifies the impact of exposure to chemical mixtures neurodevelopmental trajectories in early childhood; exploring whether associations of structural racism with child neurodevelopment are mediated by exposure to chemical mixtures or epigenetic aging; and to explore racial and ethnic differences in preconception exposure to environmental tobacco smoke and children’s respiratory health outcomes. Further, our proposed research will be enhanced by a comprehensive Plan for Enhancing Diverse Perspectives (PEDP) that leverages institutional infrastructure for diversity, equity, and inclusion, will provide mentoring to team members who are at different career stages, and engage community partners, governmental officials, and advocacy groups with whom we have trusting relationships.

PI_NAMEs: NORTHRUP, THOMAS FRANCIS;SYMANSKI, ELAINE ;WHITWORTH, KRISTINA WALKER (contact)

PROJECT_TERMS: Address;Advocacy;Affect;Area;Behavioral;Biological;biological adaptation to stress;Biological Process;built environment;career;Chemicals;Child;Child Health;Cities;Clinic;cohort;Cohort Studies;Communities;community engagement;community partners;Complex;Conceptions;Data Element;Discrimination;Disparity;early childhood;Ensure;Environmental Health;environmental health disparity;environmental tobacco smoke;environmental tobacco smoke exposure;epigenetic aging;Epigenetic Process;equity, diversity, and inclusion;ethnic difference;ethnic diversity;Ethnic Origin;experience;Exposure to;Feedback;Funding;Geography;gulf coast;Hazardous Waste Sites;Health;health disparity;Heterogeneity;improved;Individual;Information Dissemination;Infrastructure;Institution;Life Cycle Stages;Life Experience;Mediating;Mediator;Medical center;member;Mentors;National Institute of Child Health and Human Development;National Institute of Environmental Health Sciences;National Institute on Minority Health and Health Disparities;Neighborhoods;neurodevelopment;Neurodevelopmental Impairment;novel;Outcome;Participant;Pathway interactions;Pattern;Perinatal;Physiological;Policies;postnatal period;Pregnant Women;prenatal;Process;Program Development;programs;psychosocial stressors;Race;racial difference;racial diversity;recruit;Regulation;Research;Research Design;Research Personnel;respiratory;respiratory health;Risk Factors;Role;Site;social;social culture;social health determinants;Societies;Stress;structural determinants;Structural Racism;System;Texas;Toxic Environmental Substances;Toxicant exposure;Translations;Trust;United States Health Resources and Services Administration;urban area;Woman

PROJECT_TITLE: Exploring Pathways through which Structural Racism Impacts Children's Environmental Health


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Heart Disease;Nutrition;Obesity;Physical Activity;Prevention;Sleep Research

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Obesity is a major contributor to the risk for cardiovascular disease and the rates of obesity have continued to climb over the past 2 decades, driven by poor diet, inactivity, and reduced sleep. The support provided by this career development award will allow me to dedicate more time to training the next generation of clinical researchers to ensure they have the skills and expertise to address this important problem. It will also allow me to develop new research collaborations and research skills that will expand and enhance my own research program which is dedicated to improving lifestyle weight loss strategies to treat obesity, reduce chronic disease risk, and improve public health.

PI_NAMEs: CATENACCI, VICTORIA A (contact)

PROGRAM_OFFICER_NAME: DONZE, LAURIE FRIEDMAN

PROJECT_TERMS: Acceleration;Achievement;Address;Adult;Advisory Committees;Ancillary Study;Atrial Fibrillation;Award;Behavior;Behavior Therapy;Behavioral;Biological;Blood Pressure;Body mass index;Body Weight decreased;Caloric Restriction;Cardiometabolic Disease;cardiometabolism;Cardiovascular Diseases;cardiovascular disorder risk;career;Career Mobility;Chronic Disease;circadian;Clinical;Clinical Investigator;clinical training;Collaborations;Complex;Conduct Clinical Trials;Coronary Arteriosclerosis;Data;Dedications;design;Development;Diet;disorder risk;Doctor of Philosophy;Eating;effective intervention;Energy Intake;Energy Metabolism;Ensure;Epidemic;evidence base;Evidence based intervention;Exercise;experience;Faculty;Food;Funding;Glycosylated hemoglobin A;Goals;graduate student;Grant;Health;Heart failure;High Density Lipoprotein Cholesterol;improved;Individual;Infrastructure;innovation;Institution;interdisciplinary collaboration;Interdisciplinary Study;interest;Intermittent fasting;Intervention;Intervention Trial;K-Series Research Career Programs;Knowledge;Leadership;Life Style;lifestyle intervention;Maintenance;Measures;Medical Students;Medicine;Mentors;Mentorship;Methodology;Mid-Career Clinical Scientist Award (K24);Midcareer Investigator Award in Patient-Oriented Research;Morbid Obesity;next generation;novel;nutrition;Obesity;obesity development;obesity treatment;Participant;Patient Education;patient oriented;patient oriented research;Pattern;Persons;Physical activity;Physicians;Physiology;Positioning Attribute;Postdoctoral Fellow;Prediction of Response to Therapy;Prevalence;Productivity;programs;psychosocial;Public Health;Publications;Recording of previous events;Research;Research Personnel;Research Training;Resources;response;Risk;Risk Factors;Risk Reduction;Role;Scientist;secondary analysis;skill acquisition;skills;Sleep;Sleep Deprivation;success;Time;Training;training opportunity;Training Programs;Translating;treatment research;treatment response;trial design;Triglycerides;undergraduate student;Unhealthy Diet;United States National Institutes of Health;Weight;weight loss intervention;weight loss program;weight maintenance;Weight maintenance regimen

PROJECT_TITLE: Training the Next Generation of Innovative and Collaborative Patient-Oriented Researchers to Reduce Obesity and Improve Cardiometabolic Health

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(MA)]


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Pediatric;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: Project Narrative: Alzheimer’s Disease and Related Disorders (ADRD) are an increasing threat to older individuals. Some have suggested that bilingual individuals may be at lower risk for ADRD. If true, this could provide important clues about how to prevent and possibly treat ADRD. However, research to date has featured a range of conflicting findings and murky results. This application seeks to examine the basic premise that individual raised in bilingual homes are at lower risk for ADRD in their later years by using a large, national study of older Americans. It also addresses several related questions, such as whether family of origin immigration, socioeconomic status, or adolescent cognitive ability can explain any links between bilingualism and ADRD.

PI_NAMEs: CHAPMAN, BENJAMIN P (contact)

PROGRAM_OFFICER_NAME: KING, JONATHAN W

PROJECT_TERMS: Address;Adolescence;Adolescent;Age;age difference;age group;Age of Onset;Alzheimer's disease diagnosis;Alzheimer's disease related dementia;Alzheimer's disease risk;American;Architecture;Awareness;Back;bilingualism;Biogenesis;Brain;Censuses;Cessation of life;Childhood;Clinical Research;Cognitive;cognitive ability;cognitive enhancement;cognitive reserve;cognitive testing;cohort;Cohort Studies;Country;Data;Dementia;design;Development;Diagnosis;disorder risk;Education;Educational Status;Epidemiology;epidemiology study;executive function;Family;follow-up;Generations;Health;high school;Home;Household;Immigration;Incidence;indexing;Individual;Laboratories;Language;late life;lens;Life;Life course epidemiology;Link;Literature;Measurement;Measures;Mediating;Mediation;Mediator;mortality;older adult;Older Population;Outcome;Participant;Patients;Population;prevent;Prospective, cohort study;Records;Relative Risks;Reporting;Research;Research Design;Risk;Role;Sampling;skills;Socioeconomic Factors;Socioeconomic Status;Talents;Testing;theories;United States Centers for Medicare and Medicaid Services;Update

PROJECT_TITLE: Family of Origin Bilingualism and ADRD: An Epidemiologic Study of 377,000 Older Adults in the US

STUDY_SECTION: SSPB

STUDY_SECTION_NAME: Social Sciences and Population Studies B Study Section[SSPB]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Eye Disease and Disorders of Vision;Mental Health;Neurosciences

ORG_CITY: SANTA BARBARA

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA SANTA BARBARA

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because improved understanding of the neural mechanisms supporting visual attention in the healthy human brain is a key step towards identifying possible ways the system can fail. This basic understanding is expected to lead to new theoretical frameworks from which novel diagnostic and therapeutic techniques will emerge. Individuals with Schizophrenia and those with anxiety can present with impairments in the functioning of visual attention, so identifying the neural processes supporting this cognitive ability in healthy individuals will be relevant for understanding the etiology of these and other neurological and psychiatric disorders.

PI_NAMEs: SPRAGUE, THOMAS C (contact)

PROGRAM_OFFICER_NAME: WIGGS, CHERI

PROJECT_TERMS: Anxiety;Apple;Architecture;Area;Attention;attentional control;Behavior;Behavioral;Biological Assay;Brain;Brain region;Cognitive;cognitive ability;Collaborations;Color;Complex;Computer Systems;Computing Methodologies;Data;Diagnostic;diagnostic strategy;Dimensions;Disease;Disparate;Environment;Etiology;Eye Movements;flexibility;Foundations;Functional Magnetic Resonance Imaging;Goals;Gold;Human;Image;Impairment;improved;indexing;Individual;innovation;Joints;Location;Maps;Measures;Mental Depression;Mental disorders;Methods;Modeling;Molds;Motion;Movement;Nervous System Disorder;neural;neuroimaging;neuromechanism;novel;novel diagnostics;novel therapeutics;Output;Parietal;Participant;Pattern;Performance;Plant Leaves;Process;Property;Public Health;Research;response;retinotopic;Role;sample fixation;Schizophrenia;selective attention;Series;Stimulus;Support System;System;Techniques;Testing;theories;Therapeutic;Trees;Vision;Visual;Visual attention;visual cognition;visual map;visual search;Visual System

PROJECT_TITLE: Probing the role of feature dimension maps in visual cognition

STUDY_SECTION: HCMF

STUDY_SECTION_NAME: Human Complex Mental Function Study Section[HCMF]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Hematology

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: NARRATIVE Dysregulation of platelet procoagulant response is associated with bleeding and thrombosis. However, there is a gap in knowledge around the regulation of platelet procoagulant response. To better treat bleeding and thrombosis, it is we must expand our understanding of how platelets and coagulation connect via platelet procoagulant response.

PI_NAMEs: BALLARD, ABIGAIL RENE (contact)

PROGRAM_OFFICER_NAME: HILL-PRYOR, CRYSTAL DARLEANE-ROBIN

PROJECT_TERMS: 3-Dimensional;4D Imaging;Adhesions;Affect;Agonist;Biochemical;Biological;Blood;Blood Coagulation Factor;Blood Platelets;cell type;Cells;Charge;Coagulation Process;Communication;Complex;cyclophilin D;Cytoplasmic Granules;Data;Family;Fibrin;fibrous protein;Generations;Guanosine Triphosphate Phosphohydrolases;Hemorrhage;Hemostatic Agents;Hemostatic function;Hyperactivity;imaging platform;Impairment;In Vitro;in vivo;inhibitor;Integrins;Knowledge;Link;Mediating;Megakaryocytes;member;Membrane;Mitochondria;Modeling;Monomeric GTP-Binding Proteins;Mutation;novel;Outcome;Patients;Permeability;Phosphatidylserines;Phospholipids;Phosphotransferases;Platelet Activation;Platelet aggregation;platelet function;Prevention;Process;Protein Isoforms;Proteins;Proteomics;receptor;recruit;Regulation;release of sequestered calcium ion into cytoplasm;response;rho;rho GTP-Binding Proteins;Risk;Role;Signal Transduction;Site;Surface;Talin;Thrombin;Thrombosis;thrombotic;Time;vascular injury;Work

PROJECT_TITLE: The Role of the small GTPase Rap1 in Platelet-Coagulation Interplay


ADMINISTERING_IC: FD

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_DEPT: PHARMACOLOGY

PHR: Project Narrative To develop generic Orally Inhaled Drug Products (OIDPs), the FDA currently uses the so-called “weight-of- evidence” approach with in vitro testing, pharmacokinetic, and comparative clinical endpoint or pharmacodynamic studies; this approach requires considerable time and resources. To support the development of more cost-effective generic OIDPs, this project leverages latest modeling and simulation approaches to evaluate, whether pharmacokinetic bioequivalence studies along with population pharmacokinetic or standard non-compartmental analysis can reliably support the assessment of bioequivalence for generic OIDPs. This project will consider potential drug/formulation/device related differences in regional pulmonary exposure with the final goal to support bioequivalence assessments for generic OIDPs.

PI_NAMEs: BULITTA, JURGEN BERND (contact);HOCHHAUS, GUENTHER

PROGRAM_OFFICER_NAME: FENG, KAIRUI (KEVIN)

PROJECT_TITLE: Feasibility of predicting regional lung exposure from systemic pharmacokinetic data of generic OIDPs via population pharmacokinetic modeling and non-compartmental approaches


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Neurosciences;Rare Diseases;Sleep Research

ORG_CITY: STORRS-MANSFIELD

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF CONNECTICUT STORRS

ORG_STATE: CT

PHR: PROJECT NARRATIVE: Narcolepsy with cataplexy is a debilitating neurological disorder caused by the loss of hypocretin/orexin (HCRT/OX)-expressing neurons in the lateral hypothalamic area (LHA). While HCRT/OX neurons are critical regulators of sleep/wake states, little is known about the molecular underpinnings of their synaptic function. We hypothesize that the synaptic protein C1QL3, which we have identified as uniquely expressed in HCRT/OX neurons, is a critical component of the excitatory synapses that HCRT/OX neurons make at their targets throughout the brain, and is therefore is an important contributor to HCRT/OX-mediated regulation of the sleep/wake state.

PI_NAMEs: ARMSTRONG, WILLIAM PATRICK (contact)

PROGRAM_OFFICER_NAME: BAIZER, LAWRENCE

PROJECT_TERMS: Address;Affect;Anatomy;Arousal;Axon;Behavior;Behavioral;Brain;Brain region;Cataplexy;Cell Nucleus;comparative;conditional knockout;density;Disease;Electrophysiology (science);Elements;Epitopes;excitatory neuron;Excitatory Synapse;Exhibits;Experimental Designs;Fiber;Fluorescent in Situ Hybridization;Gene Expression;gene product;Genes;Genetic Markers;Goals;Human;hypocretin;Hypothalamic structure;Immunohistochemistry;In Vitro;insight;interest;Knock-in Mouse;Knock-out;Knockout Mice;Knowledge;Lateral;Lateral Hypothalamic Area;locus ceruleus structure;LoxP-flanked allele;Mediating;Messenger RNA;Metabolism;Methods;Modernization;Molecular;Molecular Profiling;motivated behavior;Mus;Narcolepsy;Nature;Nervous System Disorder;Neuroanatomy;Neurons;Neuropeptides;Neurosciences;noradrenergic;novel;Obesity;Outcome;Patients;Pattern;Persons;Phenotype;Physiology;Play;Population;presynaptic;Proteins;receptor;Research Personnel;Rodent;Role;Science;Scientist;Severities;Signal Transduction;single molecule;single-cell RNA sequencing;Sleep;Sleep Disorders;Sleep disturbances;Sleep Fragmentations;sleep regulation;Structure;Symptoms;Synapses;synaptic function;Synaptic Transmission;Techniques;Testing;therapeutic target;Training;Vertebrates;Viral;Virus;Wakefulness;Work

PROJECT_TITLE: The role of presynaptic C1QL3 in a hypothalamic arousal circuit


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: CORAL GABLES

ORG_NAME: UNIVERSITY OF MIAMI CORAL GABLES

PHR: PROJECT NARRATIVE  The Environmental influences on Child Health Outcomes (ECHO) Program aims to understand the effects of early life factors on child health and development and therefore needs a robust cohort of children and their parents who represent the variety of U.S. populations. We propose to establish a Miami-ECHO cohort. by recruiting and retaining pregnant women (N=1,250), their offspring, and the conceiving father from Miami-Dade County (MDC), Florida, a heavily populated and dynamic metropolitan area.

PI_NAMEs: PAIDAS, MICHAEL JOHN;SANTOS, HUDSON  (contact)

PROJECT_TERMS: Address;Affect;African American population;African Caribbean;Age;Area;Asian population;Automobile Driving;Biological;Biological Process;Birth;Caring;Child;Child Development;Child Health;Childhood;cohort;Cohort Studies;Communities;Complex;Conceptions;County;Data;Discipline;Discrimination;Disease susceptibility;disorder risk;Disparity;Disparity population;early childhood;Economics;Environmental Risk Factor;ethnic diversity;ethnic minority population;Ethnic Minority Women;Ethnic Origin;Ethnic Population;experience;Family Planning;Fathers;Florida;Funding;Genes;Genome;global health;Goals;Haitian;Health;health disparity;Hispanic;Home;improved;Individual;Inequity;Infant Health;Infant Mortality;Infrastructure;Insurance Coverage;Language;late life;Latino Population;Life Experience;Linguistics;Maternal and Child Health;Mediating;member;metropolitan;middle childhood;Minority;Morbidity - disease rate;Mothers;multi-racial;multidisciplinary;neurodevelopment;Not Hispanic or Latino;offspring;Outcome;outcome disparities;Parents;Perinatal;perinatal period;Persons;Placenta;Population;Population Distributions;Population Heterogeneity;Poverty;Pregnancy;Pregnant Women;prenatal;programs;Protocols documentation;psychologic;Race;racial diversity;racial minority population;racial minority women;racial population;racism;recruit;Research;Role;Science;Scientific Advances and Accomplishments;Shapes;skin color;social;Social Environment;social genomics;social health determinants;Social Identification;social stressor;Social support;socioeconomic adversity;Spanish;Stress;United States National Institutes of Health;Woman;Work

PROJECT_TITLE: Miami-ECHO: A Cohort of Mothers, Children and Fathers in Miami-Dade County


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases;Vector-Borne Diseases

ORG_CITY: FORT COLLINS

ORG_NAME: COLORADO STATE UNIVERSITY

PHR: Project Narrative The ability of viruses to rapidly evolve allows viruses to jump into new hosts, escape immunity, and generally cause problems. This project will generate an improved understanding of the details of how viruses evolve. This will allow scientists to better predict the risk posed by certain viruses and reveal new ways to combat dangerous viruses.

PI_NAMEs: STENGLEIN, MARK D. (contact)

PROGRAM_OFFICER_NAME: ALARCON, RODOLFO M

PROJECT_TITLE: Molecular and Fitness Barriers to Bunyavirus Reassortment

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-VDT-Q(01)]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Genetics;Neurosciences

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE The goal of this proposal is to identify how phosphorylation of RNA binding proteins regulates the messenger ribonucleoprotein (mRNP) complex composition and downstream events. Defects of RNA regulation have implications in physiologic and disease processes including synaptic plasticity and neurodevelopmental diseases. Investigating how ZBP1 phosphorylation regulates the -actin mRNP in fibroblasts and neurons will provide important insight into mRNP regulation as a consequence of RNA-binding protein phosphorylation.

PI_NAMEs: NUNEZ, LETI  (contact)

PROGRAM_OFFICER_NAME: TYLER, WILLIAM A

PROJECT_TITLE: Determining the Effect of RNA Binding Protein Phosphorylation on mRNA Fate


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_NAME: HUNTER COLLEGE

PHR: Hunter College of the City University of New York, New York University, Brown University, the University of Michigan, Vanderbilt University, and Yale University recognize the need for increasing the number of highly qualified neuroscientists from diverse backgrounds. Through partnership between these institutions, we aim to continue our successful undergraduate neuroscience training program that prepares students from diverse backgrounds to enter into and succeed in PhD programs in the neurosciences.

PI_NAMEs: AOKI, CHIYE J;BURGHARDT, NESHA STAR;SCHAFE, GLENN E (contact)

PROGRAM_OFFICER_NAME: JONES, MICHELLE

PROJECT_TERMS: Academic achievement;Admission activity;Advisory Committees;Area;Award;Basic Science;career;Central Nervous System;Cities;Clinical;cognitive neuroscience;cohort;college;Computers;Country;curriculum enhancement;Data Analyses;Dedications;design;Development;Disabled Persons;disadvantaged background;Doctor of Philosophy;economic disparity;education research;Educational Curriculum;educationally disadvantaged;Environment;Ethnic Population;experience;Exposure to;Faculty;Fellowship;follow-up;Funding;Future;Goals;graduate school;Growth;hands on research;Hearing;higher education;improved;Individual;Institution;Instruction;interest;Literature;Measurable;meetings;Mentors;Methods;Michigan;Modification;Monitor;Neurosciences;Neurosciences Research;New York;next generation;Oral;Population;Program Effectiveness;programs;Qualifying;racial diversity;racial population;recruit;Research;Research Activity;Research Personnel;Research Training;skills;social disparities;Societies;Structure;student training;Students;success;Testing;tool;Training;Training and Education;training opportunity;Training Programs;undergraduate student;Underrepresented Populations;United States National Institutes of Health;Universities;Work;Writing

PROJECT_TITLE: BP-ENDURE at Hunter and NYU


NIH_SPENDING_CATS: Clinical Research;Health Services;Networking and Information Technology R&D (NITRD);Patient Safety;Pediatric;Prevention;Primary Health Care;Telehealth

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: PROJECT NARRATIVE Telemedicine, the delivery of medical care through live audio-video technology, was incorporated into primary care for children rapidly in 2020 without evidence to inform best practices. While telemedicine offers the opportunity to enhance the delivery of primary care to children, careful examination of the impact of telemedicine on health outcomes and equity across primary care tasks such as preventive, acute, and chronic care is needed. We will perform quantitative examination of visits completed via telemedicine and of children receiving care through telemedicine-using practices along with qualitative identification of strategies to optimize the impact of telemedicine using over 1,000 practices’ electronic health records from 2018-25 providing evidence to guide research, policy, and practice to advance child health and health equity into the future.

PI_NAMEs: FIKS, ALEXANDER GABRIEL (contact);RAY, KRISTIN N

PROGRAM_OFFICER_NAME: KING, TRACY

PROJECT_TERMS: Academy;Acute;acute care;Address;adolescent health;Adoption;American;Antibiotics;Asthma;Attention deficit hyperactivity disorder;Caring;Case Study;Characteristics;Child;Child Care;Child Health;Childhood;Chronic;Chronic Care;Clinic;Clinical;Communities;Community Health;comparative;Competence;COVID-19 pandemic;Data;design;Electronic Health Record;Engineering;Equity;experience;Family Practice;Future;Goals;Health;health care delivery;health equity;Health Personnel;Health Promotion;Health system;Immunization;improved;Interruption;Interview;Knowledge;Lead;Medical;member;Methods;Modeling;Neighborhood Health Center;Outcome;Outcome Study;patient population;patient safety;Patients;Pediatric Research;pediatrician;Pediatrics;Persons;Physicians;Policies;Population;pre-pandemic;Preventive;Preventive care;Primary Care;primary care patient;primary care practice;primary care visit;Principal Investigator;Process;programs;Provider;Publications;Quality of Care;Reporting;Research;Respiratory Tract Infections;Sampling;Social Distance;sociodemographics;Structure;Subgroup;System;Technology;Telemedicine;Time Series Analysis;Variant;Visit

PROJECT_TITLE: Telemedicine Integrated into Pediatric Primary Care & Child Outcomes

STUDY_SECTION: HSQE

STUDY_SECTION_NAME: Health Services: Quality and Effectiveness Study Section[HSQE]


ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative Sarcopenia, the loss of muscle mass and function with age, is a condition bound to increase in prevalence with an aging population. The muscle changes involved include not only reduction in mass but also changes in muscle quality not easily visualized with current methods. This work aims to develop efficient MRI techniques to investigate these changes in better detail, improving scientific understanding of the mechanisms of sarcopenia and how they relate to muscle function.

PI_NAMEs: SVEINSSON, BRAGI  (contact)

PROGRAM_OFFICER_NAME: CARTER, CHRISTY

PROJECT_TERMS: 3-Dimensional;Affect;Age;aging population;Agreement;Awareness;Binding;Biological Markers;bone imaging;carbene;Clinical;clinical biomarkers;Communities;Consensus;Data;design;Development;diagnostic criteria;Diffusion;Elderly;Evaluation;falls;Fatty acid glycerol esters;Fiber;Fracture;Frequencies;Future;Gait speed;Geriatrics;Goals;Hand Strength;Health;Health Personnel;Hospitalization;Human;Image;imaging biomarker;imaging modality;Imaging Techniques;improved;in vivo;Inflammation;innovation;Investigation;Life Expectancy;Lipids;Machine Learning;Magnetic Resonance;Magnetic Resonance Imaging;Measurement;Measures;Medical Imaging;Metabolic;Metabolic Marker;Methods;Morbidity - disease rate;Morphologic artifacts;Morphology;Muscle;muscle form;Muscle function;muscle strength;Muscular Atrophy;muscular structure;Noise;novel;older adult;Patients;Phase;Physiologic pulse;potential biomarker;Predisposition;Prevalence;Protons;Proxy;quantitative imaging;radio frequency;recruit;Relaxation;Research;Resolution;Role;Running;sarcopenia;Signal Transduction;Site;Skeletal Muscle;Soleus Muscle;Spatial Distribution;spectroscopic imaging;Spectrum Analysis;structural imaging;Structure;Techniques;Testing;therapy development;Time;Tissues;Treatment Effectiveness;United States;Visualization;Water;Work

PROJECT_TITLE: Quantitative and Spectroscopic Imaging of Skeletal Muscle Changes in Sarcopenia at High Field

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ORG_CITY: MADISON

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE The Wisconsin Head and Neck Cancer SPORE seeks to identify and translate new scientific discoveries into significant and durable treatment advances for patients with Head and Neck Cancer (HNC). These advances strive to increase HNC cure rates and diminish normal tissue toxicities.

PI_NAMEs: HARARI, PAUL M (contact)

PROGRAM_OFFICER_NAME: HUBBARD, LEAH

PROJECT_TERMS: Anatomy;Animal Model;anti-cancer research;Appearance;axl receptor tyrosine kinase;Biological Markers;Biological Models;Biomedical Engineering;Biometry;Blood Vessels;Breathing;cancer clinical trial;Cancer Patient;career;career development;Cells;checkpoint inhibition;Clinical;Clinical Research;Clinical Trials;Collaborations;Complex;curative treatments;Data;Data Set;Deglutition;design;Development;Diagnosis;Disease;Family;feasibility testing;Fibroblasts;Future;Goals;Grant;Head and Neck Cancer;head and neck cancer patient;Head and neck structure;Immune;Immune response;Immunologics;immunoregulation;improved;improved outcome;individual patient;Industry;inhibitor;Laboratory Research;Laboratory Study;Link;Location;Lymphatic;Malignant Neoplasms;Mediating;Metastatic/Recurrent;model building;Modeling;Morbidity - disease rate;multidisciplinary;Neoplasm Metastasis;neoplastic cell;Newly Diagnosed;Normal tissue morphology;novel;oral HPV-positive head and neck cancers;Outcome;Pathology;patient response;Patient-Focused Outcomes;Patients;Phase I Clinical Trials;Pilot Projects;Play;Population;Postoperative Period;Pre-Clinical Model;Preclinical Testing;Prediction of Response to Therapy;predictive modeling;programs;Quality of life;Radiation;Radiation therapy;Radioisotopes;Radionuclide therapy;receptor;Receptor Protein-Tyrosine Kinases;Reproduction spores;Research;research and development;Research Personnel;Research Project Grants;Research Support;Resources;response;Role;Scientist;Series;single-cell RNA sequencing;Social Interaction;Speech;success;targeted delivery;Testing;Therapeutic;Tissue Microarray;Toxic effect;Translating;Translational Research;Translational trial;treatment response;treatment strategy;Treatment-related toxicity;tumor;tumor growth;tumor microenvironment;Tumor Tissue;tumor-immune system interactions;Universities;Wisconsin;Work

PROJECT_TITLE: Head and Neck Cancer SPORE at the University of Wisconsin


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Rare Diseases

PROJECT_TERMS: Administrative Coordination;Administrator;Budgets;Cancer Center;Clinical Research;Collaborations;Communication;Communities;Complex;data communication;data exchange;data quality;data sharing networks;Ensure;Evaluation;experience;Goals;Grant;Head and Neck Cancer;Head and neck structure;Human;Infrastructure;Leadership;meetings;Minority;Mission;Monitor;Performance;Principal Investigator;Program Development;programs;Research;Research Activity;Research Personnel;Research Project Grants;Research Support;Resource Sharing;Resources;Services;Structure;Supervision;Translation Process;translational progress;Translational Research;Translations;Universities;Wisconsin

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Immunotherapy;Orphan Drug;Radiation Oncology;Rare Diseases

PHR: PROJECT NARRATIVE – PROJECT 1 Despite advances in treatments including the introduction of immunotherapies, metastatic or recurrent head and neck squamous cell cancers are typically incurable and, to begin changing this, we propose to develop and investigate a new treatment approach that combines the most common form of immunotherapy (immune checkpoint inhibitors) with targeted radionuclide therapy. Radiation can damage tumors in a way that renders them more responsive to immunotherapies, however conventional radiation therapy typically cannot treat all tumor sites in patients with metastatic disease because of toxicities and the inability to target small tumors that are not identified on imaging scans. Targeted radionuclide therapies injected into a patient’s vein go throughout the body to preferentially deliver radiation to tumors wherever they are located and here we will (1) determine the effect of this type of treatment on the susceptibility of tumors to immune response; and (2) test the effectiveness of this type of treatment when combined with the most common form of immunotherapy in order to determine which combinations should be most beneficial in patients with metastatic or recurrent head and neck cancer.

PI_NAMEs: MORRIS, ZACHARY SCOTT (contact)

PROJECT_TERMS: 90Y;Albumins;analog;Anatomy;anti-PD-1;anti-PD1 therapy;anti-tumor immune response;Antigen Presentation;Binding;CD8-Positive T-Lymphocytes;checkpoint inhibition;chelation;Clinical;Clinical Research;Clonal Expansion;Combined Modality Therapy;curative treatments;Data;Development;Disease;Disseminated Malignant Neoplasm;Dose;dosimetry;effectiveness testing;exhaust;exhaustion;External Beam Radiation Therapy;follow-up;Generations;Goals;Grant;Halogens;Head and Neck Cancer;Head and Neck Squamous Cell Carcinoma;Image;Immune checkpoint inhibitor;Immune response;Immune Tolerance;Immunity;immunogenic cell death;Immunologics;immunoregulation;Immunotherapy;improved;in situ vaccine;in vivo;Infiltration;Inflammation;insight;Interferons;Ligands;Location;Malignant Neoplasms;Metastatic/Recurrent;Modality;Modeling;mouse model;Mus;Mutation;neoantigens;Neoplasm Metastasis;neoplastic cell;next generation;novel;novel therapeutic intervention;Outcome;patient derived xenograft model;Patients;Phase;phase I trial;pre-clinical;preclinical study;Preclinical Testing;Predisposition;Publishing;Radiation;Radiation therapy;Radioisotopes;Radionuclide therapy;receptor;Recurrence;Regulatory T-Lymphocyte;Reporting;research clinical testing;response;Safety;Scanning;Site;Surface;T cell clonality;T cell infiltration;T-cell receptor repertoire;T-Lymphocyte;targeted treatment;Testing;Therapeutic Effect;Toxic effect;Translations;Treatment Protocols;tumor;Tumor Antigens;Tumor Immunity;tumor microenvironment;tumor xenograft;Tumor-infiltrating immune cells;Tumor-Infiltrating Lymphocytes;Universities;uptake;Veins;Wisconsin

PROJECT_TITLE: Project 1: Priming and propagating immunity against head and neck cancer using targeted radionuclide therapy


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Genetics;Human Genome;Infectious Diseases;Orphan Drug;Precision Medicine;Radiation Oncology;Rare Diseases

PHR: PROJECT NARRATIVE – PROJECT 2 Successful completion of this research would provide a new tool to stratify HNC patients who are more likely to respond to specific treatments. Single cell CITE-seq of HNC tumors combined with patient-specific bioengineered models could identify biomarkers and provide a platform to test many treatments and thereby predict the most effective treatment strategies for individual patients. Our clinical pilot study which will investigate the feasibility of using bioengineered models to direct patient treatment contributes to our goal of improving clinical decision making and helping provide the most effective treatment for each HNC patient which would have a major impact on patient treatment outcomes and quality of life.

PI_NAMEs: BEEBE, DAVID J (contact)

PROJECT_TERMS: Address;advanced disease;angiogenesis;anti-PD-1;Architecture;Biological Markers;biomarker identification;Biomedical Engineering;Blood;cancer biomarkers;Cancer Model;Carcinoma;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Cetuximab;chemoradiation;Chemotherapy and/or radiation;Clinical;clinical decision-making;Clinical Research;cohort;Complex;Data;data modeling;Data Set;Detection;Disease;Dose;Eastern Cooperative Oncology Group;effective therapy;efficacy testing;Environment;Epidermal Growth Factor Receptor;experience;experimental study;feasibility testing;Fibroblasts;Future;Gene Expression;Gene Expression Profile;Genomics;Goals;Head and Neck Cancer;head and neck cancer patient;HPV negative;HPV oropharyngeal cancer;HPV positive;Immune;improved;in vivo;Individual;individual patient;Infrastructure;Larynx;Lymphatic;Measures;Modeling;Molecular;molecular marker;multiple omics;Neoplasm Circulating Cells;Nivolumab;novel;novel marker;Operative Surgical Procedures;Oral cavity;oral HPV-positive head and neck cancers;Organoids;Patient Care;patient stratification;Patient-Focused Outcomes;Patients;phase 2 study;Phenotype;PIK3CG gene;Pilot Projects;Population;Postoperative Period;Prediction of Response to Therapy;predictive marker;predictive modeling;predictive tools;primary endpoint;Primary Neoplasm;Progression-Free Survivals;protein expression;Proteins;Proteomics;Quality of life;Radiation;Radiation therapy;Radiation Tolerance;reconstitution;Regimen;Reporting;Research;response;response biomarker;Risk;Sampling;secondary endpoint;single-cell RNA sequencing;spheroids;Stains;standard of care;Stratification;Stromal Cells;success;Survival Rate;systemic toxicity;T-cell inflamed;targeted treatment;Testing;Therapeutic;Time;timeline;Tissue Microarray;Tissue Sample;Tissue-Specific Gene Expression;Tissues;tool;transcriptomics;Treatment Efficacy;treatment group;Treatment outcome;treatment response;treatment strategy;treatment stratification;tumor;tumor growth;tumor microenvironment;Tumor Tissue;Universities;Wisconsin;Work

PROJECT_TITLE: Project 2: Predicting Treatment Responses Using Single Cell RNA Sequencing and Bioengineered Patient-derived Organotypic Models of HNC