ED_INST_TYPE: SCHOOLS OF EDUCATION

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Estrogen;Neurodegenerative;Neurosciences;Vascular Contributions to Cognitive Impairment and Dementia (VCID);Women's Health Research

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

PHR: Project Narrative Poor cerebral blood flow is associated with high risks of stroke, dementia, and Alzheimer’s Disease, all of which are linked to poor brain blood vessel function. These brain conditions can be more prominent in men versus women, suggesting function of brain blood vessels may differ between the sexes. The goal of this application is to examine sex differences and similarities in how brain vessels function in healthy men and women, particularly when the brain demands more blood flow. These findings can be used as a platform to determine how vascular function declines with age or disease in unique ways in men versus women. Only then can we understand the most promising ways to restore function of brain blood vessels with optimal sex-specific treatments. The findings of how sex influences brain blood vessel function will provide ideas on how to limit disease progression, or improve function, in an effort to restore the quality of life of both sexes as they age successfully.

PI_NAMEs: SCHRAGE, WILLIAM G (contact)

PROGRAM_OFFICER_NAME: CHARETTE, MARC F

PROJECT_TERMS: 4D MRI;active control;Acute;Address;Adult;Age;age related decline;Aging;Agreement;Alzheimer's Disease;animal data;Animals;Anterior;arterial spin labeling;Automobile Driving;Blood flow;Blood Vessels;Brain;brain circulation;Brain region;cerebral artery;Cerebral Hypoxia;cerebrovascular;Cerebrovascular Circulation;Cerebrovascular Disorders;Cerebrovascular Physiology;Cerebrovascular system;Cerebrum;Clinical;clinically relevant;comorbidity;Data;Dementia;design;Diabetes Mellitus;Disease;Disease Progression;disorder risk;Endothelium;Estradiol;Estrogens;Etiology;Exhibits;Female;Functional disorder;functional improvement;functional restoration;gain of function;Goals;Gonadal Steroid Hormones;Health;high risk;high risk population;Hormones;Human;Hypercapnia;Hypertension;Hypoxia;in vivo;insight;juvenile animal;Knowledge;Link;Long-Term Care;loss of function;Magnetic Resonance Imaging;male;Mediating;men;Methods;multimodal data;Nitric Oxide;Nitric Oxide Synthase;novel;Obesity;Outcome;Patients;Pattern;Perfusion;pharmacologic;physiologic stressor;Physiological;Population;pre-clinical;Premenopause;programs;Prostaglandin-Endoperoxide Synthase;Prostaglandins;Quality of life;Rattus;regional difference;Regulation;Research;Research Design;Resolution;response;Rest;Risk;sex;Sex Differences;sexual dimorphism;Sexual Reassignment;Signal Transduction;Stimulus;Stress;stroke risk;Supplementation;Techniques;technological innovation;Testing;Testosterone;Therapeutic;vascular contributions;vasoconstriction;Vasodilation;Vasodilator Agents;Woman;women versus men;young adult

PROJECT_TITLE: Human cerebral blood flow regulation: sex, mechanism, and stress differences

STUDY_SECTION: CICS

STUDY_SECTION_NAME: Clinical and Integrative Cardiovascular Sciences Study Section[CICS]


ADMINISTERING_IC: HL

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: PHILADELPHIA

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: LAY NARRATIVE  Obstructive sleep apnea is a very common disorder that is heterogeneous with different pathways to disease and multiple subtypes. This program of research is designed to develop a Precision Medicine approach to the condition. It will develop new tools to predict disease earlier and more effectively (thereby facilitating earlier identification and treatment), understand biomarkers relevant to important disease consequences (thereby facilitating earlier preventative measures) and provide a personalized assessment of risk for important aspects of disease heterogeneity (thereby facilitating more personalized disease management and characterization).

PI_NAMEs: PACK, ALLAN I (contact)

PROGRAM_OFFICER_NAME: BAIZER, LAWRENCE

PROJECT_TERMS: adverse outcome;Advisory Committees;Affect;Anatomy;Apnea;Area;biobank;Biological;Biological Markers;Biological Models;biomarker development;Biometry;Blood Pressure;blood pressure reduction;Body System;cardiovascular risk factor;Cardiovascular system;Caring;Cells;Characteristics;Chronic Obstructive Pulmonary Disease;Clinical;clinical application;clinical care;Clinical Data;clinical heterogeneity;clinical subtypes;clinical translation;clinically relevant;comorbidity;craniofacial;craniofacial structure;Data;Data Analyses;Data Collection;data integration;data quality;Data Set;design;Development;Diagnosis;Dimensions;Disease;disease heterogeneity;disorder prevention;Drosophila genus;Drowsiness;Early identification;Early treatment;effectiveness evaluation;Ensure;Epigenetic Process;Etiology;Evaluation;Fatty acid glycerol esters;Genes;Genetic;genetic association;genetic risk factor;genetic signature;Genetic study;genetic variant;genome wide association study;genomic locus;Glues;Goals;Grant;Heritability;Heterogeneity;Hypoxia;improved;Individual;Informatics;Information Dissemination;Infrastructure;interest;Knowledge;Link;Lung Diseases;Machine Learning;Magnetic Resonance Imaging;Manuscripts;Mediating;Medicine;meetings;metabolomics;Methods;MicroRNAs;Modeling;mouse model;multiple omics;Mus;novel marker;novel strategies;Obesity;Obstructive Sleep Apnea;Outcome;Pathway interactions;Patient Care;patient engagement;personalized approach;personalized diagnostics;personalized management;personalized medicine;Phenotype;Physiological;polygenic risk score;pre-clinical;precision medicine;prevent;Prevention;Preventive measure;Process;prognostic;programs;Publishing;quality assurance;Reaction;Research;Research Design;Research Personnel;Research Proposals;response;Risk;Risk Assessment;Risk Factors;Role;Sampling;Sleep;Sleep Deprivation;Sleep Disorders;Sleep Fragmentations;soft tissue;statistical and machine learning;Symptoms;Techniques;Tongue;tool;trait;transcriptome sequencing;Treatment Effectiveness;treatment response;Update;Work;Writing;X-Ray Computed Tomography;Zebrafish

PROJECT_TITLE: Developing a P4 Medicine Approach to Obstructive Sleep Apnea

STUDY_SECTION: HLBP

STUDY_SECTION_NAME: Heart, Lung, and Blood Program Project Study Section[HLBP(OA)]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Machine Learning and Artificial Intelligence;Mental Health;Neurosciences

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: Narrative The human brain’s superficial white matter (SWM) plays an important role in neurodevelopment and aging and has been implicated in a large number of diseases. Despite its significance, the SWM is vastly underrepresented in current descriptions of the human brain connectome due to multiple challenges that have thus far prevented comprehensive mapping of the SWM. We propose to address these challenges to create the most comprehensive, anatomically curated maps of the SWM to date, which will enable its study in health and disease.

PI_NAMEs: MAKRIS, NIKOLAOS ;O'DONNELL, LAUREN JEAN (contact);RATHI, YOGESH

PROGRAM_OFFICER_NAME: BENNETT, YVONNE MARIE

PROJECT_TERMS: Address;Aging;Algorithms;Alzheimer's Disease;Anatomy;Architecture;Atlases;Auditory area;autism spectrum disorder;Bipolar Disorder;Brain;Brain Diseases;Brain Mapping;Communities;comparative;Complex;Computer software;connectome;Data;Data Set;Databases;deep learning;design;Diffusion Magnetic Resonance Imaging;Disease;Epilepsy;experimental study;Fascicle;Fiber;Generations;Goals;Health;Human;human subject;Huntington Disease;Image;improved;in vivo;Individual;inter-individual variation;Iron;Literature;Location;Machine Learning;Magnetic Resonance Imaging;Maps;Methods;millimeter;Monkeys;Morphology;Myelin;Names;Neuroanatomy;neurodevelopment;novel;novel strategies;Ontology;open source;Play;prevent;Relaxation;Resolution;Role;Schizophrenia;Shapes;Source;System;Testing;Tissues;Tracer;tractography;Translating;ultra high resolution;Visual;white matter

PROJECT_TITLE: Mapping the superficial white matter connectome of the human brain using ultra high resolution multi-contrast diffusion MRI

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


NIH_SPENDING_CATS: Lung;Sleep Research

PHR: LAY NARRATIVE  This Core provides support to the Program of Research to facilitate obtaining advice about scientific direction, administration of the program, financial management and liaison with other entities and programs at the University of Pennsylvania, and in other institutions.

PROJECT_TERMS: Advisory Committees;Agreement;Ancillary Study;Businesses;California;career;Chronobiology;circadian;Clinical Research;Collaborations;Data;data integration;data management;data sharing;Development;Discipline of Nursing;experience;Facebook;Faculty;faculty mentor;faculty research;Florida;Genetic;Genetic study;Genomics;Glues;Goals;graduate student;Grant;Iceland;Infrastructure;Institution;Letters;Manuscripts;medical schools;Medicine;meetings;Michigan;Names;next generation;Obstructive Sleep Apnea;Occupational activity of managing finances;Ohio;Pennsylvania;Play;Postdoctoral Fellow;programs;Records;Reporting;Research;Research Personnel;Research Training;Role;Series;Site;Site Visit;Sleep;Sleep Apnea Syndromes;social media;Training;Translational Research;Twitter;United States National Institutes of Health;Universities;virtual;web site;Work

PROJECT_TITLE: Administrative Core

STUDY_SECTION_NAME: Heart, Lung, and Blood Program Project Study Section[HLBP]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Cervical Cancer;Genetics;Infectious Diseases;Sexually Transmitted Infections;Women's Health Research

ORG_CITY: CHICAGO

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: The proposed studies are directed at understanding how the DNA damage repair pathways are activated in human papillomavirus (HPV) positive cells. Our studies have shown that activation of these pathways is important for viral replication and the proposed studies will examine if this occurs through the action of topoisomerases or R-loops which are RNA: DNA hybrids that lead to stalled replication forks. Finally, additional studies will examine the specific role DNA damage repair pathways play in the life cycle of HPVs

PI_NAMEs: LAIMINS, LAIMONIS A. (contact)

PROGRAM_OFFICER_NAME: READ-CONNOLE, ELIZABETH LEE

PROJECT_TERMS: Anus;Ataxia Telangiectasia;ataxia telangiectasia mutated protein;ATM activation;ATR gene;Binding;Binding Proteins;BRCA1 gene;Cell Differentiation process;cell motility;Cells;Cervical;Cessation of life;CHEK1 gene;Chromosomes;Complex;Country;cytokine;DNA;DNA biosynthesis;DNA Damage;DNA Repair;DNA replication fork;Episome;Event;experimental study;Fanconi Anemia pathway;GATA4 gene;Generations;Genetic Recombination;Genetic Transcription;Genome;Goals;homologous recombination;HPV positive;HPV-High Risk;Human papilloma virus infection;Human Papillomavirus;Hybrids;Impairment;in vivo;insight;knock-down;Laboratories;Lead;Lesion;Life Cycle Stages;Link;Maintenance;malignant mouth neoplasm;Malignant neoplasm of cervix uteri;Malignant Neoplasms;member;Mitosis;Mutation;new therapeutic target;Pathway interactions;Phosphotransferases;Play;prevent;Preventive vaccine;Process;Productivity;Proteins;recombinational repair;recruit;repaired;response;RNA;Role;single-cell RNA sequencing;Site;Stratified Squamous Epithelium;Stratum Basale;Stress;therapeutically effective;Time;Topoisomerase;Topoisomerase II;Undifferentiated;Viral;viral DNA;Viral Genome;Viral Physiology;Viral Proteins;virus episome maintenance;Virus Integration;Virus Replication;Work

PROJECT_TITLE: Renewal: HPV and the DNA Damage Response

STUDY_SECTION: VIRA

STUDY_SECTION_NAME: Virology - A Study Section[VIRA]


NIH_SPENDING_CATS: Lung;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Sleep Research

PHR: LAY NARRATIVE  The Biostatistics and Data Analysis Core, or its equivalent, has supported sleep research at the University of Pennsylvania under the leadership of Greg Maislin, Adjunct Professor of Statistics in Medicine, since 1989. Members of the Core work collaboratively with faculty and investigators to ensure appropriate methods are used in the conduct of research proposals, directly supporting study design, data collection and quality assurance, statistical programming and analysis, dissemination of results, and manuscript and grant writing. The Core will leverage this expertise and dedication to sleep research in support of the individual Projects and overall Program.

PI_NAMEs: MAISLIN, GREG  (contact)

PROJECT_TERMS: Biometry;Biostatistics Core;causal model;Collaborations;Collection;Communication;Complex;Complex Analysis;computer science;Computer software;Data;Data Analyses;Data Collection;data integration;data quality;data resource;Databases;Dedications;design;Development;Disease;disorder risk;efficacy study;electronic health data;Electronic Health Record;endophenotype;Ensure;Epidemiology;experience;Faculty;genetic analysis;Genomics;Grant;Health protection;Human;Image;indexing;Individual;Individual Differences;Information Dissemination;Institution;large scale data;Leadership;Machine Learning;Manuscripts;Measures;Medicine;meetings;member;Methods;Modeling;Neurobiology;novel strategies;Obesity;Observational Study;Obstructive Sleep Apnea;Paper;Pennsylvania;Play;Process;professor;programs;Protocols documentation;Public Health Schools;Publications;Publishing;Pulmonary Heart Disease;Pythons;quality assurance;randomized trial;recruit;Reporting;Research;Research Design;Research Personnel;Research Proposals;Resources;Risk Factors;Role;Sleep;Sleep Apnea Syndromes;statistical and machine learning;Statistical Methods;statistics;Supervision;Techniques;Training;Treatment Efficacy;Universities;Work;Writing

PROJECT_TITLE: Biostatistics and Data Analysis


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Depression;Hematology;Mental Health;Mental Illness;Neurosciences

ORG_CITY: VERMILLION

ORG_NAME: UNIVERSITY OF SOUTH DAKOTA

ORG_STATE: SD

PHR: Trophic factor molecules play important roles in brain development, neuronal function and behavior. The proposed studies will investigate the role of trophic factor activity in cognition. These studies can lead to the development of trophic factor therapeutics for cognitive dysfunction.

PI_NAMEs: SATHYANESAN, SAMUEL NEWTON (contact)

PROGRAM_OFFICER_NAME: NADLER, LAURIE SUE

PROJECT_TERMS: Acute;Adverse effects;Anemia;Anti-Inflammatory Agents;Attention;Behavior;Behavioral;Behavioral Assay;Biochemical;Biological Assay;Bipolar Disorder;Blood coagulation;Blood Vessels;Blood Viscosity;blood-brain barrier crossing;Brain;Chemical Engineering;Chronic;Clinic;Clinical;clinical translation;Clinical Trials;Cognition;Cognitive;Cognitive deficits;cognitive enhancement;cognitive function;CREB1 gene;Dangerousness;Data;dentate gyrus;Development;Disabling;Disease;Dorsal;Dose;Erythropoietin;Erythropoietin Receptor;Event;experimental study;Functional disorder;Functional impairment;genetic manipulation;Goals;Health;Hematopoiesis;Hematopoietic;Hemostatic Agents;hippocampal subregions;Hippocampus;Hormones;Human;Impaired cognition;Impairment;improved;Individual;insight;Knockout Mice;Knowledge;Ligands;Major Depressive Disorder;Marketing;Mediating;Memory;Mental Depression;Mental disorders;Molecular;Molecular Mechanisms of Action;Nervous System Disorder;neurobiological mechanism;Neurobiology;Neurocognitive;Neuronal Dysfunction;Neuronal Plasticity;Neurons;neuropsychiatric disorder;Neurotransmitters;neurotrophic factor;novel;Nuclear;object recognition;Pathway interactions;Performance;Peripheral;Pharmaceutical Preparations;pharmacologic;Physiological;Platelet Count measurement;Play;pre-clinical;preservation;Property;Psychiatry;receptor;receptor function;Receptor Signaling;Red Blood Cell Count;Regulation;Resolution;Risk;Rodent;Role;Safety;Schizophrenia;Short-Term Memory;Signal Transduction;social stress;Stress;Testing;Therapeutic;Therapeutic Agents;therapeutic development;Thinking;transcription factor;Transgenic Mice;Viral

PROJECT_TITLE: Trophic Factors in Cognition

STUDY_SECTION: PMDA

STUDY_SECTION_NAME: Pathophysiological Basis of Mental Disorders and Addictions Study Section[PMDA]


NIH_SPENDING_CATS: Behavioral and Social Science;Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;HPV and/or Cervical Cancer Vaccines;Health Services;Immunization;Infectious Diseases;Orphan Drug;Pediatric;Prevention;Primary Health Care;Rare Diseases;Sexually Transmitted Infections;Urologic Diseases;Vaccine Related

ORG_CITY: SAINT LOUIS

ORG_DEPT: PEDIATRICS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative The ultimate goal of the proposal is to provide critical new knowledge in how to change care delivery in the primary care setting to ensure optimal use of the human papilloma virus (HPV) vaccine and to inform implementation of future cancer-preventing vaccines targeting children. Primary prevention of HPV-related urogenital and oropharyngeal cancers could significantly reduce morbidity, mortality, and healthcare costs associated with these commonly occurring cancers.

PI_NAMEs: KING, ALLISON A (contact)

PROGRAM_OFFICER_NAME: KOBRIN, SARAH

PROJECT_TERMS: 17 year old;Address;Age;age group;behavior change;Belief;boys;care delivery;Caring;Centers for Disease Control and Prevention (U.S.);Child;Child health care;Clinical;Cluster randomized trial;Collaborations;Communication;community based research;Computerized Medical Record;Control Groups;cost;Country;Crying;Data;Diphtheria;Dose;Education;effectiveness evaluation;Effectiveness of Interventions;Eligibility Determination;Ensure;Evaluation;Exposure to;Feedback;Female;Future;future implementation;girls;Goals;Guidelines;Health Care Costs;Healthy People 2020;Human Papilloma Virus Vaccination;Human Papilloma Virus Vaccine;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;implementation evaluation;implementation fidelity;implementation strategy;improved;innovation;Intervention;intervention effect;Knowledge;Malignant neoplasm of cervix uteri;Malignant Neoplasms;malignant oropharynx neoplasm;Measures;Mediating;Meningococcal vaccine;Missouri;Morbidity - disease rate;mortality;Motivation;multi-component intervention;Oncogenic;Outcome;Parents;Patients;Pertussis;Pilot Projects;pilot test;post intervention;practice-based research network;preadolescence;prevent;Primary Care;primary care provider;primary care setting;primary outcome;Primary Prevention;Provider;provider behavior;provider communication;provider intervention;Recommendation;Reporting;Research Personnel;Sampling;satisfaction;Schools;secondary outcome;Self Efficacy;Series;sexual debut;sexually transmitted virus;skills;study population;System;Target Populations;Testing;Tetanus;Theoretical Domains framework;theories;Time;Translating;United States;uptake;Urogenital Cancer;Vaccinated;Vaccination;vaccination outcome;vaccine delivery;Vaccines;Visit;Waiting Lists;Work

PROJECT_TITLE: RCT to Evaluate an Implementation Strategy to Increase Optimal Use of HPV Vaccine in Primary Care

STUDY_SECTION: PRDP

STUDY_SECTION_NAME: Psychosocial Risk and Disease Prevention Study Section[PRDP]


NIH_SPENDING_CATS: Data Science;Lung;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Precision Medicine;Prevention;Sleep Research

PHR: PROJECT NARRATIVE This Program Project grant focused on development of a P4 Medicine Approach to Obstructive Sleep Apnea clinical care will conduct scientific studies that predict obstructive sleep apnea (OSA), prevent OSA and its adverse consequences, and personalize therapies and clinical care in OSA care diagnosis. In order to study OSA through these proposed projects, diverse and complex data including physiological, imaging, molecular, clinical, and survey data must be effectively collected, managed, integrated, and analyzed. The Data Integration Core will play a key role across all projects by developing infrastructure and implementing processes to create high quality datasets necessary to answer scientific questions posed by each project study.

PI_NAMEs: HOLMES, JOHN H. (contact)

PROJECT_TERMS: Accounting;Address;Adherence;adverse outcome;Affect;Area;Big Data;Bioinformatics;biomedical informatics;Biomedical Research;Biometry;burden of illness;Caring;Chronic Disease;circadian biology;Clinical;clinical care;Clinical Data;clinical database;Clinical Research;cohort;Collaborations;Collection;Communities;complex data;computerized data processing;Continuous Positive Airway Pressure;cost;Data;data acquisition;Data Analyses;Data Collection;data integration;data management;Data Management Resources;Data Reporting;data resource;Data Science;Data Set;Data Sources;Data Storage and Retrieval;database design;Development;Diagnosis;digital health;Disease;diverse data;Economic Burden;economic cost;Electronic Health Record;Ensure;Epidemiologist;Epidemiology;experience;FAIR principles;Foundations;Generations;Genetic Markers;genome sciences;Genotype;Goals;health data;heterogenous data;Image;Individual;Informatics;informatics infrastructure;Information Systems;Infrastructure;Knowledge;Lead;Leadership;Machine Learning;Managed Care;Medical;Medicine;member;Methods;Mining;Modeling;Molecular;molecular marker;multimodality;Obstructive Sleep Apnea;open source;Patients;personalized diagnostics;personalized medicine;Persons;Physiological;Play;prevent;Prevention;Process;Program Research Project Grants;programs;Protocols documentation;remote monitoring;Research Personnel;Resolution;Sleep;Surveys;Technology;Terminology;tool;Training;Validation;Work

PROJECT_TITLE: Data Integration Core


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

ORG_CITY: TUCSON

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: PROJECT NARRATIVE In 2019, virtually all 31,620 prostate cancer (PCa) deaths in the United States were attributed to metastasis. The standard anti androgen-receptor signaling therapy is only effective for up to 2 years in patients with aggressive metastatic PCa. To broaden therapeutic options, this proposal aims to resolve mechanisms of how SNAI1 and AR coordinate the seeding and metastatic outgrowth of prostate cancer cells at distant organs.

PI_NAMEs: TRAN, JACK  (contact)

PROGRAM_OFFICER_NAME: ADAMS, GREGORY

PROJECT_TERMS: Address;Androgen Antagonists;Androgen Receptor;anti-cancer research;Binding;Biological Assay;Breast Cancer Model;cancer cell;Cancer Patient;cancer seeding;cancer type;CCND1 gene;Cell Count;Cell Cycle;cell growth;Cell Proliferation;Cells;Cessation of life;chromatin immunoprecipitation;Clinical;Cyclin D1;Data;deep learning algorithm;design;Development;Distant;Down-Regulation;Doxycycline;Elements;Epithelial Cells;Epithelium;Event;Frequencies;Future;Genetic Transcription;Goals;Growth;Human;In Vitro;in vivo;Inhibition of Cell Proliferation;Injections;innovation;insight;Invaded;knock-down;Malignant neoplasm of prostate;Measures;Mediating;Mesenchymal;Messenger RNA;Metastatic Prostate Cancer;Micrometastasis;migration;Modeling;Monitor;Morphology;Mus;Nature;Neoplasm Circulating Cells;Neoplasm Metastasis;neoplastic cell;NPR2 gene;Organ;overexpression;Patients;Physiological;prevent;Process;programs;Proliferating;promoter;Property;Prostate;prostate cancer cell;prostate cancer metastasis;prostate cancer progression;Proteins;receptor binding;Receptor Signaling;Regulation;Reporting;Repression;Research;Resistance development;Risk;RNA Interference;Role;Sampling;Site;Stains;System;Testing;Therapeutic;Tissue Microarray;tumor;Tumor Promotion;United States;Vimentin;virtual;wound healing

PROJECT_TITLE: Coordinated Actions of SNAI1 and AR in Prostate Cancer Dissemination and Metastatic Outgrowth


NIH_SPENDING_CATS: Cancer;Clinical Research;Hematology;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Nonembryonic - Human

ORG_CITY: STONY BROOK

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

ORG_STATE: NY

PHR: PROJECT NARRATIVE Human tissues show high levels of genetic mutations, yet such mutant tissues rarely develop frank tumors. The goal of this research proposal is to understand the molecular mechanisms controlling the competitive interactions between normal and mutant cells, and how these mechanisms break down during cancer progression. While accumulation of mutations is unavoidable during aging, results from this study will have the potential to identify new strategies to control neoplastic cell expansion and prevent the development of a full-blown malignancy.

PI_NAMEs: ZHAN, HUICHUN  (contact)

PROGRAM_OFFICER_NAME: KLAUZINSKA, MALGORZATA

PROJECT_TERMS: Acute leukemia;advanced disease;Aging;Allogenic;AMD3100;Biological Assay;Blood specimen;Cancer Relapse;CD34+CD38- cell;Cell Compartmentation;Cell Count;Cell Line;Cell Maintenance;Cell Physiology;cell type;Cells;chemokine;Clonal Expansion;Clustered Regularly Interspaced Short Palindromic Repeats;Coculture Techniques;curative treatments;CXCR4 Receptors;Development;Disease;DNA Sequence Alteration;Dose;Evolution;exhaustion;experience;experimental study;Exposure to;Gene Expression Profile;Genetic;Goals;Hematopoiesis;Hematopoietic;hematopoietic stem cell expansion;Hematopoietic stem cells;Hematopoietic System;Homing;Human;human disease;human tissue;Immune;Immunity;immunoregulation;Immunosuppression;In Vitro;in vivo;in vivo Model;Individual;induced pluripotent stem cell;JAK2 gene;knock-down;lentiviral-mediated;leukemia;Ligands;Longterm Follow-up;Malignant Neoplasms;Mediating;Memory;Modeling;Molecular;mouse model;Mus;mutant;Mutation;Myeloproliferative disease;neoplastic cell;Normal Cell;notch protein;overexpression;Patients;Peptides;peripheral blood;Phosphotransferases;Play;Population;prevent;progenitor;Proliferating;Relapse;Reporting;Research Proposals;Risk;Role;self-renewal;Signal Transduction;stem;stem cell differentiation;stem cell function;Stem cell transplant;stem cells;stemness;Stromal Cell-Derived Factor 1;System;T-Cell Depletion;T-Lymphocyte;Technology;Testing;Therapeutic;Time;Tissues;Transplantation;tumor;tumor microenvironment;tumor progression;Tumor Stem Cells;tumor-immune system interactions;Work

PROJECT_TITLE: Cell Competition in Myeloproliferative Neoplasms

STUDY_SECTION: TME

STUDY_SECTION_NAME: Tumor Microenvironment Study Section[TME]


NIH_SPENDING_CATS: Clinical Research;Dental, Oral, and Craniofacial Disease;Genetics;Human Genome;Lung;Machine Learning and Artificial Intelligence;Prevention;Sleep Research

PHR: LAY NARRATIVE  Obstructive sleep apnea is a common condition that can be passed down through the family. Differences in face shape and structure are also passed down through families and related to sleep apnea. We will look at genetic factors, differences in the structures of the head, and differences in sleep apnea to see how they are related. The results of this study will help us to understand who will get sleep apnea, why they get it, and how bad it may affect them.

PI_NAMEs: SCHWAB, RICHARD J. (contact)

PROJECT_TERMS: Address;Affect;Anatomy;biobank;Biological;Biological Models;Body Weight decreased;Caring;causal variant;Cells;Clinic;Clinical;clinical application;clinical care;cohort;Complex;Computerized Medical Record;craniofacial;Data;design;Development;Disease;DNA Sequence Alteration;Early Diagnosis;Early identification;Early treatment;Etiology;exome sequencing;Face;Family;Fatty acid glycerol esters;Frequencies;Genes;Genetic;genetic analysis;genetic association;genetic predictors;Genetic Risk;Genetic study;genetic variant;Genetic Variation;genome wide association study;genomic locus;Head;Head and neck structure;Heritability;Heterogeneity;Human;Image;improved;in silico;Individual;innovation;insight;Knowledge;Length;Link;Machine Learning;machine learning algorithm;Magnetic Resonance;Magnetic Resonance Imaging;Mandible;Medicine;men;Methods;middle age;novel;Obesity;Obstructive Sleep Apnea;Oral;Outcome;Pathogenesis;Pathway interactions;Patients;Penetrance analysis;Pennsylvania;phenome;Phenotype;polygenic risk score;poor health outcome;population based;precision medicine;Process;programs;rare variant;Risk;Risk Factors;risk variant;Role;screening;Shapes;Signal Transduction;Skeleton;Sleep;Sleep Apnea Syndromes;soft tissue;Structure;Susceptibility Gene;Techniques;Thinness;Tongue;tool;trait;Translations;Universities;Variant;Woman;Work;X-Ray Computed Tomography

PROJECT_TITLE: Genetics of Extreme Phenotypes of OSA and Associated Upper Airway Anatomy


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Bioengineering;Dental, Oral, and Craniofacial Disease;Infectious Diseases

ORG_DEPT: DENTISTRY

PHR: Advances in engineering approaches offer previously unimagined opportunities to advance the NIDCR 2030 vision of precision oral health for all. To harness this opportunity, a critical mass of cross-trained dentists and engineers engaged in oral and craniofacial research are urgently needed. We will develop this workforce.

PI_NAMEs: KOO, HYUN  (contact);STEBE, KATHLEEN J

PROGRAM_OFFICER_NAME: MCGUIRL, MICHELE

PROJECT_TERMS: Address;Adopted;Applied Research;Artificial Intelligence;Awareness;Binding;Biology;career;career development;Clinical;Clinical Research;Committee Members;Complex;Computational Science;craniofacial;craniofacial complex;Dedications;Dental;Dental caries;Dental Schools;Dentistry;Dentists;Development;Disease;Educational workshop;Elements;Engineering;Enrollment;Environment;experience;Faculty;Family;Funding;Healthcare;Immunity;Industry;innovation;Journals;K-Series Research Career Programs;malignant mouth neoplasm;materials science;Medical;Medicine;Mentors;Mentorship;microbiome;Minority;Mouth Diseases;multidisciplinary;Nanotechnology;novel;novel strategies;Oral;oral biofilm;Oral health;Patients;Pennsylvania;Periodontal Diseases;personalized medicine;Persons;Population;Postdoctoral Fellow;Poverty;Predisposition;programs;Records;Regulatory Affairs;Reproducibility;Research;Research Project Grants;Resources;Robotics;Schools;Science;Scientist;symposium;tissue regeneration;Training;Training Programs;Translational Research;Universities;Vision;Writing

PROJECT_TITLE: Advanced Training at the Interface of Engineering and Oral-Craniofacial Sciences


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Hematology;Immunotherapy;Lymphatic Research;Lymphoma;Orphan Drug;Rare Diseases

PHR: Narrative – Inhibition of T-Cell Receptor Signaling for Treatment of Adult T-Cell Leukemia-Lymphoma Human T-cell leukemia virus type 1 is a cause of an aggressive T-cell lymphoma, adult T-cell leukemia- lymphoma (ATLL), refractory to combination chemotherapy. This project will examine the role of T-cell receptor signaling pathway proteins, PKCβ and IRF4, and potential IRF4-inhibitory agent, lenalidomide, in ATLL progression and treatment, respectively. Success in this endeavor will provide an active therapeutic approach to ATLL, and possibly other T-cell lymphomas.

PI_NAMEs: RATNER, LEE  (contact);RAUCH, DANIEL ARTHUR

PROGRAM_OFFICER_NAME: SONG, MIN-KYUNG H

PROJECT_TERMS: Address;Adult T-Cell Leukemia/Lymphoma;Affect;Alleles;Angiogenesis Inhibitors;Animal Model;Anti-viral Therapy;Antisense Oligonucleotides;antitumor effect;Apoptosis;Binding;Biological Assay;Biological Markers;Bone Marrow;Caspase;cell immortalization;Cell Line;chemotherapy;Clinic;Clinical;Clinical Trials Network;Clonality;Clustered Regularly Interspaced Short Palindromic Repeats;Combination Drug Therapy;Correlative Study;CRISPR/Cas technology;cytotoxic;Development;Disease;Exons;experience;gain of function mutation;Gene Expression;gene product;Gene Targeting;Genes;Genome;Genotype;Growth;Human T-lymphotropic virus 1;Imides;Immune;Immunodeficient Mouse;immunoregulation;improved;Individual;inhibitor;International;Investigational Therapies;IRF4 gene;knock-down;Knock-out;Knowledge;lenalidomide;leukemia/lymphoma;Lymphoma cell;Malignant Neoplasms;Mature T-Lymphocyte;Mediating;Molecular;Monitor;Multi-Institutional Clinical Trial;Mus;Mutate;Mutation;new therapeutic target;Nuclear;overexpression;participant enrollment;Pathogenesis;Pathway interactions;phase 1 study;Phase I Clinical Trials;phase I trial;phospholipase C gamma;PLC gamma1;Positioning Attribute;Prediction of Response to Therapy;Proliferating;Protein Inhibition;protein kinase C beta;Proteins;Receptor Signaling;recruit;Refractory;Registries;Relapse;Repression;response;Role;small hairpin RNA;success;synergism;T Cell Receptor Signaling Pathway;T-Cell and NK-Cell Neoplasm;T-Cell Lymphoma;T-Cell Receptor;T-Lymphocyte;targeted treatment;Testing;Therapeutic;therapeutic target;therapy resistant;transcription factor;Transcriptional Activation;transcriptome;transcriptome sequencing;Translating;Transplantation;Treatment Efficacy;tumorigenesis;ubiquitin-protein ligase;Validation;Viral Genome;Viral Oncogene;Virus

PROJECT_TITLE: Inhibition of T-cell Receptor Signaling for Treatment of Adult T-cell Leukemia Lymphoma

STUDY_SECTION: CONC

STUDY_SECTION_NAME: Clinical Oncology Study Section[CONC]


ADMINISTERING_IC: FD

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: BLOOMINGTON

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: TRUSTEES OF INDIANA UNIVERSITY

ORG_STATE: IN

PHR: Accelerated Sample Preparation for Microbial Pathogen Detection in Large Number of Pet  Project Narrative We propose a project consisting in animal food sample collection, accelerated food sample preparation to bring microorganisms of interest to detection levels, and FDA approved detection methods. This will be applied to test 250 samples pairing Dog treat/Salmonella.

PI_NAMEs: XIMENES, EDUARDO  (contact)

PROGRAM_OFFICER_NAME: LI, MEI-YING

PROJECT_TITLE: Microbiology Animal Food Project Testing Track 3 Accelerated Sample Preparation for Microbial Pathogen Detection in Pet Food Samples


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

ORG_CITY: FORT COLLINS

ORG_NAME: COLORADO STATE UNIVERSITY

ORG_STATE: CO

PHR: Project Narrative The overarching aim of this project is to support food defense efforts in the State of Colorado by establishing a radioanalytical measurements laboratory capable of monitoring food products for radioactive contaminants. The initial efforts will focus on providing a laboratory capable of monitoring food samples for gamma-emitting radionuclides in support of food defense. Simultaneously the capability to measure alpha-emitting radionuclides will be developed by drawing on the facilities available at CSU and the expertise and the background of the faculty in the Health Physics program.

PI_NAMEs: SUDOWE, RALF  (contact)

PROJECT_TITLE: Establishing a Radioanalytical Measurements Laboratory (RAM LAB) for Food Monitoring at Colorado State University


PHR: LAY NARRATIVE  Establishing biomarkers for determining disease severity and treatment benefits is a critical research opportunity highlighted in the National Institutes of Health and National Center on Sleep Disorders Research 2021 Sleep Research Plan. Although obstructive sleep apnea (OSA) is a common disorder, there are no blood biomarkers for identification and management of these patients. This project will study microRNAs in order to develop and validate blood biomarkers that are specific to OSA, useful for identification of cases with OSA, reflective of efficacy of therapy, and able to predict blood pressure response to treatment of OSA.

PI_NAMEs: MAGALANG, ULYSSES J (contact)

PROJECT_TERMS: Affect;Age;Area;Asthma;Biological Markers;biomarker identification;Blood;Blood Pressure;Body mass index;Cardiovascular Diseases;cardiovascular risk factor;case control;Cholesterol;Chronic Obstructive Pulmonary Disease;Clinical;clinical risk;clinical translation;Code;comorbidity;Complement;Continuous Positive Airway Pressure;Data;Diabetes Mellitus;Disease;Drowsiness;Educational workshop;Effectiveness;effectiveness measure;efficacy evaluation;Enrollment;Etiology;Exclusion Criteria;Foundations;Goals;Hour;Hypertension;Hypoxia;improved;Individual;International;Literature;Lung Diseases;Measurement;Measures;Medicine;Methods;microRNA biomarkers;MicroRNAs;Monitor;next generation sequencing;Obstructive Sleep Apnea;Participant;Pathogenesis;Patients;Persons;polygenic risk score;population based;positive airway pressure;precision medicine;predictive signature;Predictive Value;Process;prognostic;prognostic value;programs;Proteins;recruit;Reporting;Research;response;Risk;Risk Factors;risk stratification;RNA;Sample Size;Sampling;Severities;Severity of illness;sex;Sleep;Sleep Disorders;Sleep disturbances;Sleep Fragmentations;sleep regulation;Sleeplessness;specific biomarkers;Symptoms;Techniques;Testing;Therapeutic;Translations;Treatment Efficacy;treatment response;United States National Institutes of Health;Untranslated RNA;Validation

PROJECT_TITLE: MicroRNAs as Biomarkers for Obstructive Sleep Apnea


ORG_CITY: IOWA CITY

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Project Narrative - Overall: This cooperative agreement is intended to enhance the capacity and capabilities of human food testing in the state of Iowa in support of an integrated food safety system. Sample testing in the areas of microbiology, chemistry, and radiochemistry, and the development of special projects will support and expand capacity and capability. Successful completion of this multi-disciplinary project will strengthen and improve the collaboration on surveillance testing between the FDA and the State Hygienic Laboratory and will help the FDA enhance its nationally integrated food safety system and reinforce the mission to detect, prevent, and minimize the effects of foodborne exposures.

PI_NAMEs: MAY, DUSTIN  (contact)

PROJECT_TITLE: Food Defense and Surveillance in Support of the FDA by the State Hygienic Laboratory at the University of Iowa


NIH_SPENDING_CATS: Cancer

ORG_CITY: SAN FRANCISCO

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: Project Narrative We are proposing an innovative new training program to encourage surgical residents to pursue clinician-scientist careers in surgical oncology and position them for leadership roles in the field. The program is unique in that it will not only train surgical oncologists in the biology, methods and clinical science of cancer, but will also teach them how to shepherd their research advances through the complex regulations and delivery environment of our modern healthcare system.

PI_NAMEs: ESSERMAN, LAURA J (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: Grant;Surgical Oncology;Training

PROJECT_TITLE: Surgical Oncology Training Grant

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


ORG_CITY: NEW HAVEN

ORG_DEPT: PSYCHIATRY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative This renewal of the Autism Biomarkers Consortium for Clinical Trials seeks to further validate a set of reliable electrophysiological and eye-tracking biomarkers to facilitate clinical trials evaluating treatments for autism spectrum disorder (ASD). Sensitive, reliable, and objective biomarkers related to social function are needed to support development of individualized, effective treatment methods and, ultimately, improve outcomes for individuals with ASD.

PI_NAMEs: MCPARTLAND, JAMES CHARLES (contact)

PROGRAM_OFFICER_NAME: GILOTTY, LISA

PROJECT_TERMS: 5 year old;autism biomarker;autism spectrum disorder;autistic children;Biological;Biological Assay;Biological Markers;Blood;Characteristics;Child;Clinical;Clinical Research;clinical trial enrollment;Clinical Trials;Cognitive;cohort;Collaborations;Communication;Communities;Data;data acquisition;Data Analyses;Data Collection;data integration;data management;data repository;Databases;design;Detection;Development;Diagnostic;Discrimination;DNA;effective therapy;Electroencephalography;Electrophysiology (science);Enrollment;Ensure;Ethics;Exhibits;experience;Face;Feasibility Studies;Follow-Up Studies;Future;Genomics;Goals;Heterogeneity;Human;improved outcome;indexing;Individual;individuals with autism spectrum disorder;informatics infrastructure;Leadership;Measurement;Measures;Methodology;Methods;middle childhood;National Institute of Mental Health;Neurodevelopmental Disorder;Nursery Schools;oculomotor;operation;Parents;Participant;Pattern;Phase;potential biomarker;Predictive Value;Process;programs;Property;Psychometrics;Qualifying;Quality Control;Research;Research Design;Research Personnel;Resources;Sample Size;Sampling;School-Age Population;Secure;Site;social communication;Social Functioning;Stratification;Testing;Time;U-Series Cooperative Agreements;United States National Institutes of Health;visual tracking;Work

PROJECT_TITLE: The Autism Biomarkers Consortium for Clinical Trials


NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Intellectual and Developmental Disabilities (IDD);Mental Health;Networking and Information Technology R&D (NITRD);Neurosciences;Pediatric

PROJECT_TERMS: 5 year old;Agreement;autism biomarker;autism spectrum disorder;autistic children;Biological Assay;Biological Markers;Blood;Blood specimen;Characteristics;Child;Clinical;Clinical Research;clinical trial enrollment;Clinical Trials;Cognitive;cohort;Collaborations;Collection;Communication;computerized data processing;Data;data acquisition;Data Analyses;Data Analytics;Data Collection;data integration;data management;data quality;data repository;data sharing;data standards;Databases;Dedications;design;Development;Discrimination;Documentation;Electroencephalography;Enrollment;Ensure;Ethics;Excision;experience;Face;Feasibility Studies;Feedback;file format;Follow-Up Studies;Generations;Goals;Good Clinical Practice;Heterogeneity;Human;indexing;Individual;informatics infrastructure;Institutional Review Boards;Lead;Leadership;Maintenance;Manuals;Measures;meetings;member;Methodology;middle childhood;Monitor;Morphologic artifacts;National Institute of Mental Health;Neurodevelopmental Disorder;Nursery Schools;Occupational activity of managing finances;oculomotor;operation;Persons;Phase;Procedures;programs;Property;Protocols documentation;Psychometrics;Qualifying;Quality Control;recruit;Reporting;Research;Research Design;Research Personnel;Sample Size;Sampling;School-Age Population;Secure;Site;Site Visit;social communication;Social Functioning;Source;Specific qualifier value;Stratification;Testing;Time;timeline;U-Series Cooperative Agreements;United States National Institutes of Health;Update;visual tracking;Work

PROJECT_TITLE: Administrative Core


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative This grant supports the training of scientists working in a broad spectrum of oral health research fields that range from basic and translational biological research, to clinical, public health and sociobehavioral research. We provide trainees with strong research skills in their specific disciplines as well as with skills to work on multi- and interdisciplinary research teams to facilitate the translation of research findings into clinical and community-based applications that improve the public's health.

PI_NAMEs: CHI, DONALD LESLIE (contact)

PROGRAM_OFFICER_NAME: FUQUA, CHANTEL FAYSAN

PROJECT_TERMS: Appointment;Area;Authorship;Basic Science;Behavioral;Biometry;career;career development;Clinical;craniofacial;craniofacial structure;Dental;Dentists;Development;Development Plans;Discipline;Disease;Doctor of Philosophy;Doctor's Degree;Eligibility Determination;Engineering;Epidemiology;experience;Funding;genetic approach;Goals;Grant;Health;Health Sciences;Health system;Human Resources;improved;Individual;Interdisciplinary Study;interest;member;Mentors;Molecular;National Institute of Dental and Craniofacial Research;Oral;Oral health;Outcome;population health;Positioning Attribute;post-doctoral training;Postdoctoral Fellow;pre-doctoral;Process Measure;programs;Public Health;Public Health Schools;Publications;Research;Research Training;School Dentistry;school health;Scientist;skills;stem cell biology;tissue regeneration;Training;Training Programs;Translating;Translational Research;Universities;Washington;Work

PROJECT_TITLE: Comprehensive Training in Inter-Disciplinary Oral Health Research


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Data Science;Intellectual and Developmental Disabilities (IDD);Mental Health;Networking and Information Technology R&D (NITRD);Neurosciences;Pediatric

PI_NAMEs: WEBB, SARA JANE (contact)

PROJECT_TERMS: 5 year old;Agreement;autism biomarker;autism spectrum disorder;Biological Assay;Biological Markers;biomarker identification;blind;Characteristics;Child;Clinical;Clinical Research;clinical trial enrollment;Clinical Trials;Cognitive;cohort;Collaborations;Communication;computerized data processing;Data;data acquisition;Data Analyses;data analysis pipeline;data exchange;data integration;data management;data pipeline;data repository;Data Storage and Retrieval;data warehouse;Databases;Dedications;Derivation procedure;design;Detection;Development;Dimensions;Discrimination;Electroencephalography;Ensure;Equipment;Ethics;Excision;experience;experimental study;Faculty;Feasibility Studies;Feedback;follow-up;Follow-Up Studies;Future;Goals;Hour;improved;informatics infrastructure;Knowledge;Leadership;Manuals;Manuscripts;Measures;member;method development;Methodology;Monitor;Morphologic artifacts;Names;novel;Nursery Schools;open source;operation;Participant;Peer Review;Phase;Procedures;Process;Productivity;Property;Protocols documentation;Psychometrics;Publishing;Quality Control;Research;Research Design;Research Personnel;Role;Sample Size;Schedule;School-Age Population;Secure;Services;Site;social attention;social communication;Social Functioning;Standardization;Statistical Data Interpretation;Stratification;Structure;success;symposium;Telephone;Testing;Time;timeline;Training;U-Series Cooperative Agreements;United States National Institutes of Health;Update;Variant;visual processing;visual tracking;Work

PROJECT_TITLE: Data Acquisition and Analysis Core


NIH_SPENDING_CATS: Genetics;Human Genome;Lung;Precision Medicine;Prevention;Sleep Research

PHR: NARRATIVE  Sleep apnea affects a lot of people, but symptoms differ for people with similar severity of disease. More work is needed to understand what causes differences in these symptoms. This study will use many types of biological measures to identify differences in sleep patterns, genetics, and other measures that contribute to differences in sleep apnea. We will use this information to figure out how to better identify people with sleep apnea and predict the symptoms they may have, which can also help predict the consequences they are most likely to experience. In the end, this project will lead to a more complete knowledge of sleep apnea.

PI_NAMEs: JUSTICE, ANNE  (contact)

PROJECT_TERMS: Affect;Apnea;Arousal;Biological;Biological Models;biomarker identification;Cardiac health;cardiovascular risk factor;causal variant;Cells;Clinical;cohort;Communities;cost effective;Data;data resource;Diagnosis;disorder risk;DNA Methylation;Drowsiness;Electroencephalography;Epigenetic Process;experience;follow-up;Frequencies;Gene Expression;Genetic;genetic analysis;genetic architecture;Genetic Risk;genetic risk factor;genetic variant;Genetic Variation;genome wide association study;genome-wide;genomic locus;Genomic Segment;Genomics;Goals;Health;Heritability;Hispanic;improved;in silico;indexing;Individual;insight;Intervention;Investigation;Knowledge;Laboratories;Maps;Measures;Medical;Medicine;Meta-Analysis;Metabolic;metabolomics;Methodology;Methods;methylomics;Molecular;Multiomic Data;multiple omics;National Heart, Lung, and Blood Institute;novel;Obstructive Sleep Apnea;Odds Ratio;Outcome;Pathway interactions;Patient Self-Report;Patients;Persons;Phenotype;Physiological;Physiology;polygenic risk score;Polysomnography;precision medicine;Predictive Factor;programs;Reproducibility;Research;response;Risk;Risk Factors;risk variant;Sampling;Severity of illness;Signal Transduction;Sleep;Sleep Apnea Syndromes;Sleep Architecture;Sleep Disorders;Sleep disturbances;sleep pattern;sleep physiology;Sleep Stages;Snoring;Staging;Symptoms;Testing;trait;Trans-Omics for Precision Medicine;transcriptomics;Visual;Work

PROJECT_TITLE: Mechanisms that Account for Different Symptom Subtypes of OSA


NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric

PI_NAMEs: DZIURA, JAMES DAVID (contact)

PROJECT_TERMS: 5 year old;Agreement;autism biomarker;autism spectrum disorder;autistic children;Biological Assay;Biological Markers;biomarker discovery;Caregivers;Characteristics;Child;Clinical;Clinical and Translational Science Awards;clinical biomarkers;clinical center;clinical investigation;Clinical Research;clinical trial enrollment;Clinical Trials;Cognitive;cohort;Collaborations;Collection;Communication;Communities;Data;data acquisition;Data Analyses;data cleaning;Data Collection;Data Files;data management;data quality;data repository;data standards;data submission;Databases;design;Development;Discrimination;Documentation;Electroencephalography;Enrollment;Ensure;Ethics;Evaluation;experience;Face;Feasibility Studies;file format;follow-up;Follow-Up Studies;Generations;Goals;Health Insurance Portability and Accountability Act;Health protection;Heterogeneity;Home;Human;Impairment;indexing;Informatics;informatics infrastructure;Information Dissemination;Information Management;Infrastructure;innovation;innovative technologies;Internet;Leadership;Maintenance;Measures;meetings;Methodology;Methods;middle childhood;Mission;Monitor;Multi-Institutional Clinical Trial;multidisciplinary;National Institute of Mental Health;Neurodevelopmental Disorder;Nursery Schools;oculomotor;operation;performance site;Phase;Preparation;Privacy;Procedures;Process;programs;Property;Psychometrics;Qualifying;quality assurance;Quality Control;Reporting;Research;Research Design;Role;Sample Size;Sampling;School-Age Population;Secure;Security;Site;Site Visit;social;social communication;Social Functioning;Source;Stratification;Structure;System;Technology;Testing;Time;tool;U-Series Cooperative Agreements;United States National Institutes of Health;visual tracking;Work

PROJECT_TITLE: Data Coordinating Core


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Cancer;Clinical Research;Radiation Oncology

ORG_NAME: DANA-FARBER CANCER INST

PHR: Project Narrative Despite recent technological advances, on-treatment imaging for radiotherapy procedures is still a significant challenge for tens of thousands of patients. According to the American College of Radiology, megavoltage (MV) volumetric imaging has a clear advantage in terms of metal artifact reduction, direct dose calculation and real-time adaptive radiotherapy, but is challenged by low contrast and high imaging doses. We have demonstrated that this limitation can be overcome by a novel multi-layer imager to provide high-contrast, low- dose on-treatment MV imaging which will remove metal artifacts while retaining soft-tissue contrast and enable real-time adaptive radiotherapy. PHS 398/2590 (Rev. 06/09) Page Continuation Format Page

PI_NAMEs: BERBECO, ROSS I. (contact);FUEGLISTALLER, RONY

PROGRAM_OFFICER_NAME: KIM, BOKLYE

PROJECT_TERMS: 3-Dimensional;Acceleration;American College of Radiology;Clinic;Clinical;clinical application;clinical translation;cost;Dana-Farber Cancer Institute;Data;design;detector;Development;Devices;Dose;Electronics;experience;Future;Goals;Grant;Head and neck structure;High Performance Computing;Hour;Image;image reconstruction;imager;Imaging Device;Implant;improved;Infrastructure;innovation;invention;Knowledge;Linear Accelerator Radiotherapy Systems;Lung;Magnetic Resonance Imaging;Marketing;Medical;Metals;Methods;Monte Carlo Method;Morphologic artifacts;new technology;novel;Parents;Patients;Penetration;Performance;Physics;Procedures;Productivity;Prostate;Publishing;Radiation Oncology;Radiation therapy;reconstruction;Research;research clinical testing;Roentgen Rays;Scheme;simulation;soft tissue;System;Technology;Testing;Time;tool;Translating;United States National Institutes of Health;Vertebral column

PROJECT_TITLE: A novel flat-panel detector for advanced on-board radiation therapy imaging


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Services;Pediatric;Pediatric Cancer;Prevention;Rare Diseases;Rehabilitation

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

PHR: PROJECT NARRATIVE Long term survivors of childhood cancer, of which there are over 400,000 in the United States, have increased chronic and mental health conditions and reduced health-related quality of life and socioeconomic attainment than their peers. One such long term effect, sexual dysfunction, is identified by adolescent and young adult- aged childhood cancer survivors (AYA-CCS) as a bothersome yet unmet need affecting their mental health and quality of life. Completion of this study will lead to improved screening and diagnosis of sexual dysfunction among AYA-CCS, which is the first step in improving quality of care for this underrecognized and undertreated condition.

PI_NAMEs: DEMEDIS, JENNA  (contact)

PROGRAM_OFFICER_NAME: RADAEV, SERGEY

PROJECT_TERMS: acceptability and feasibility;Address;Adolescent and Young Adult;Adoption;Adult;Affect;Age;aged;Arousal;Award;Cancer Survivor;Cancer Survivorship;career;career development;Child;childhood cancer survivor;Chronic;Client satisfaction;Clinic;Clinical;Clinical Trials;Colorado;Communication;Consolidated Framework for Implementation Research;contextual factors;Data;design;Detection;Development;Diagnosis;Dissemination and Implementation;Educational workshop;Effectiveness;effectiveness evaluation;effectiveness testing;effectiveness/implementation study;effectiveness/implementation trial;Ensure;Environment;Evaluation;experience;Feedback;Female;Fostering;Future;future implementation;Goals;Health;health related quality of life;hybrid type 1 design;Hybrids;implementation context;implementation facilitators;implementation framework;implementation outcomes;implementation science;improved;informant;innovation;Intervention;intervention effect;Interview;Knowledge;Long-Term Effects;Long-Term Survivors;Malignant Childhood Neoplasm;Malignant Neoplasms;Medical;Medical Records;Mental Health;Mentors;Mentorship;Methods;Modification;Multicenter Studies;multidisciplinary;neuro-oncology;Oncology;Outcome;Outcomes Research;Pain;patient oriented;Patient Outcomes Assessments;patient-clinician communication;Patients;Pattern;Pediatric Hematology;Pediatric Hospitals;Pediatric Oncology;peer;Persons;Physiological;Population;Pragmatic clinical trial;pragmatic trial;preference;primary outcome;Process;Program Development;programs;prospective;Provider;Qualitative Research;Quality of Care;Quality of life;quality of life for cancer survivors;Questionnaires;randomized trial;Reach, Effectiveness, Adoption, Implementation, and Maintenance;recruit;Reporting;Research;Research Design;Research Methodology;Research Personnel;Research Proposals;research to practice;routine screening;satisfaction;Science;screening;Screening procedure;secondary outcome;sex;Sex Functioning;Sexual Dysfunction;skills;social;socioeconomics;Standardization;Surveys;survivorship;Testing;Time;tool;Training;Translational Research;treatment as usual;United States;Universities;University resources;Work;Writing

PROJECT_TITLE: Implementation and Evaluation of a Screening Tool for Sexual Dysfunction for Pediatric Cancer Survivors

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


PI_NAMEs: DAWSON, GERALDINE  (contact)

PROJECT_TERMS: 5 year old;autism biomarker;autism spectrum disorder;autistic children;Biological;Biological Assay;Biological Markers;Blood;Characteristics;Child;Clinical;Clinical Research;clinical trial enrollment;Clinical Trials;Cognitive;cohort;Collaborations;Communication;Communities;Data;data acquisition;Data Analyses;Data Collection;data integration;data management;data repository;Databases;design;Detection;Development;Diagnostic;Discrimination;DNA;Electroencephalography;Enrollment;Ensure;Ethics;Exhibits;experience;Face;Feasibility Studies;Follow-Up Studies;Future;Genomics;Goals;Heterogeneity;Human;indexing;Individual;informatics infrastructure;Leadership;Measurement;Measures;Methodology;middle childhood;National Institute of Mental Health;Neurodevelopmental Disorder;Nursery Schools;oculomotor;operation;Parents;Participant;Pattern;Phase;potential biomarker;Predictive Value;Process;programs;Property;Psychometrics;Qualifying;Quality Control;Research;Research Design;Research Personnel;Resources;Sample Size;Sampling;School-Age Population;Secure;Site;social communication;Social Functioning;Stratification;Testing;Time;U-Series Cooperative Agreements;United States National Institutes of Health;visual tracking;Work

PROJECT_TITLE: 1/5-The Autism Biomarkers Consortium for Clinical Trials


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Mental Health;Mental Illness;Neurosciences

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: We propose to create an approach for directly regulating the transfer of electrical information across neural circuits that encode emotions. After creating this new method for rewiring synapses, we will deploy it in animal models of psychiatric disorders. Thus, our high-risk research has the potential to yield a new therapeutic strategy for treating mental illnesses such as depression, anxiety, and addiction.

PI_NAMEs: DZIRASA, KAFUI  (contact)

PROGRAM_OFFICER_NAME: DRISCOLL, JAMIE DANIELLE

PROJECT_TERMS: addiction;Address;Animal Model;Anxiety;Behavior;Brain;brain cell;cell type;Cells;Connexins;designer receptors exclusively activated by designer drugs;Docking;Electrical Engineering;Electrical Synapse;Emotional;emotional behavior;Emotions;Engineering;Exhibits;experimental study;Future;high risk;Individual;member;Mental Depression;Mental disorders;Methods;model organism;neural circuit;neuroregulation;novel;novel strategies;novel therapeutic intervention;optogenetics;Physiology;Pre-Clinical Model;prevent;Property;Proteins;Research;Synapses;Testing;tool;translation to humans;Viral

PROJECT_TITLE: Precision editing of neural circuits using engineered electrical synapses


PI_NAMEs: NELSON, CHARLES ALEXANDER (contact)

PROJECT_TITLE: 2/5-The Autism Biomarkers Consortium for Clinical Trials


PI_NAMEs: JESTE, SHAFALI SPURLING (contact)

PROJECT_TITLE: 3/5-The Autism Biomarkers Consortium for Clinical Trials


PHR: LAY NARRATIVE  Genome-wide association studies, or GWAS, are a common approach to identify genes and variants of genes associated with risk of disease. While many associations have been uncovered, the fundamental question of whether the nearest gene at associated regions in the genome is truly the causal gene often remains unanswered. In this Project, we seek to answer this question using analyses in cells, mice, flies and fish to move downstream from association studies to the identification of causative genes for sleep apnea and excessive sleepiness.

PI_NAMEs: PACK, ALLAN I (contact)

PROJECT_TERMS: 3-Dimensional;Adipocytes;Affect;Anatomy;Animal Model;Animals;Astrocytes;ATAC-seq;Behavior;Biological;Biological Models;Candidate Disease Gene;candidate identification;causal variant;cell type;Cells;Chromatin;Chromatin Loop;Chromosome Mapping;Clinical;clinical translation;Communities;Complement;Complex;craniofacial;CRISPR/Cas technology;Data;Disease;disorder risk;diverse data;Drosophila genus;Drowsiness;Enhancers;Excessive Daytime Sleepiness;Fatty acid glycerol esters;Fishes;fly;follow-up;Gene Expression;gene function;Gene Targeting;Genes;Genetic;genetic association;genetic variant;Genome;genome wide association study;genome-wide;genomic locus;Genomics;Genotype;Goals;Human;Image;in silico;Induced pluripotent stem cell derived human neuron;Investments;knock-down;Knock-out;knockout gene;Knowledge;Link;Magnetic Resonance Imaging;Maps;Medicine;Mesenchymal Stem Cells;Methods;Modeling;multidimensional data;Mus;Neuroglia;Neurons;novel;Obesity;Obstructive Sleep Apnea;Osteoblasts;Pathway interactions;Patients;Phenotype;precision medicine;Process;programs;promoter;Quantitative Trait Loci;Research;Resolution;Resources;Risk;Risk Factors;RNA Interference;RNA interference screen;Sampling;Severities;Shapes;Signal Transduction;Site;Sleep;Sleep Apnea Syndromes;sleep behavior;Sleep disturbances;Sleep Fragmentations;Sleeplessness;Testing;Tongue;trait;transcriptome sequencing;Validation;Variant;Zebrafish

PROJECT_TITLE: Going from Genetic Associations to Identification of Causative Genes


PI_NAMEs: KLEINHANS, NATALIA M (contact)

PROJECT_TITLE: 4/5-The Autism Biomarkers Consortium for Clinical Trials


PROJECT_TITLE: 5/5-The Autism Biomarkers Consortium for Clinical Trials


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Lung;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: LOS ANGELES

ORG_DEPT: ORTHOPEDICS

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE Bone sarcomas are a heterogeneous group of rare tumors that are poorly characterized at the molecular and drug resistance level and for which clinical outcomes have not significantly improved over the past decade. We have developed a pipeline to establish bone sarcoma organoids from clinical samples and screen hundreds of drugs, paired with whole-genome sequencing to identify mutational correlates of drug sensitivity. Here, we will apply this validated pipeline to study how the molecular and pharmacologic behavior of bone sarcomas differs spatially within a single patient (Aim 1) and how they vary during the transition from curable primary to lethal metastatic disease (Aim 2).

PI_NAMEs: BOUTROS, PAUL CHRISTOPHER;SORAGNI, ALICE  (contact)

PROGRAM_OFFICER_NAME: AGYIN, JOSEPH KOFI

PROJECT_TERMS: Adjuvant Chemotherapy;Affect;aggressive therapy;Architecture;Behavior;Biological Models;Biopsy;Bone neoplasms;Bone Tissue;cancer diagnosis;Cell Line;Cessation of life;chemotherapy;Child;Clinical;Clinical Trials;Connective Tissue;Cytotoxic Chemotherapy;Data;Diagnosis;Disease;driver mutation;Drug resistance;Drug Screening;drug sensitivity;Evolution;exome;genome sequencing;Genomics;Germ Lines;Histologic;improved;Link;Lung;Lung nodule;Malignant Neoplasms;Metastatic Neoplasm to the Lung;model development;Modeling;Molecular;Mutation;Neoadjuvant Therapy;Neoplasm Metastasis;Newly Diagnosed;Operative Surgical Procedures;Organoids;Osteosarcoma;Outcome;Patients;Pediatric Neoplasm;Persons;Pharmaceutical Preparations;pharmacologic;Population;Portraits;pressure;Primary Neoplasm;rare cancer;reconstruction;Relapse;Resistance;response;Sampling;Sarcoma;screening;soft tissue;Specimen;Structure;Survival Rate;System;targeted treatment;Techniques;Technology;Testing;Therapeutic;therapeutic development;therapy resistant;Time;Tissue Sample;Treatment Failure;treatment response;tumor;Tumor Subtype;whole genome

PROJECT_TITLE: The Evolution of Sarcoma Drug Sensitivity through Time and Space

STUDY_SECTION: DT

STUDY_SECTION_NAME: Developmental Therapeutics Study Section[DT]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging

ORG_CITY: DAVIS

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: PROJECT NARRATIVE Public Health Relevance Statement: Radiotracers for blood flow imaging suffer from limited clinical availability. This project develops a new technical capability of the classic metabolic radiotracer 18F-FDG for simultaneous multiparametric imaging of blood flow and glucose metabolism with reduced radiation dose, imaging time and cost. The enabled single-tracer multiparametric imaging would open up many new opportunities for clinical applications that require multiparametric imaging biomarkers but have been historically restricted by the accessibility of perfusion imaging.

PI_NAMEs: WANG, GUOBAO  (contact)

PROGRAM_OFFICER_NAME: DUAN, QI

PROJECT_TERMS: Address;Alzheimer's Disease;Ammonia;Applications Grants;Blood;Blood flow;Blood Glucose;Brain;Butanols;cancer therapy;cellular imaging;Chlorides;Clinic;Clinical;clinical application;clinical care;Clinical Research;cost;Coupling;Cyclotrons;Data;detection sensitivity;Development;Disease;FDA approved;fluorodeoxyglucose;fluorodeoxyglucose positron emission tomography;Glucose;glucose metabolism;glucose transport;Goals;Half-Life;Heart Diseases;Hour;Image;image reconstruction;imaging biomarker;improved;Intravenous;ischemic cardiomyopathy;kernel methods;kinetic model;Knowledge;Length;Malignant Neoplasms;Measures;Metabolic;metabolic imaging;Metabolism;Methods;Modeling;multiparametric imaging;Myocardial;Myocardium;Neurodegenerative Disorders;Noise;Organ;Patients;perfusion imaging;photon-counting detector;Physiological Processes;Physiology;Pilot Projects;Positron-Emission Tomography;Process;Protocols documentation;Proxy;public health relevance;Radiation Dose Unit;radiotracer;Research;Scanning;Site;System;Techniques;temporal measurement;Time;Tissues;Tracer;tumor;Tumor Angiogenesis;tumor metabolism;whole body imaging;Work

PROJECT_TITLE: Single-tracer Multiparametric PET Imaging

STUDY_SECTION: ITD

STUDY_SECTION_NAME: Imaging Technology Development Study Section[ITD]


NIH_SPENDING_CATS: Cardiovascular

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: NARRATIVE The Cardiovascular Research Training Program at Brigham and Women's Hospital aims to prepare trainees for independent careers in investigative pursuits. This T-32 focusses on 1) Myocardial Cellular and Molecular Biology and Genetics, 2) Vascular Cell and Molecular Biology, and 3) Translational/Clinical Cardiovascular Research. Our environment offers substantial resources to trainees to ensure continuation of our longstanding record of preparing a talented pool of trainees for productive independent research careers.

PI_NAMEs: LIBBY, PETER  (contact)

PROGRAM_OFFICER_NAME: LIDMAN, KARIN FREDRIKSSON

PROJECT_TITLE: Training Grant in Cardiovascular Research

STUDY_SECTION: NITM

STUDY_SECTION_NAME: NHLBI Institutional Training Mechanism Study Section[NITM(OA)]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Climate-Related Exposures and Conditions;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Social Determinants of Health

ORG_CITY: PHILADELPHIA

ORG_NAME: DREXEL UNIVERSITY

PHR: Narrative The first of its kind, this nationally representative longitudinal study of age 65 and older Americans will estimate the mortality impacts of chronic indoor heat exposure, identify person- and neighborhood- level factors that impact vulnerability to indoor heat, and quantify the number of excess deaths from heat that may be prevented through housing interventions, now, and under a range of greenhouse gas emission scenarios. Results will improve understanding of the long-term burden of mortality from heat, inform upper thresholds for safe residential indoor temperatures, and provide critical information to guide region-specific housing intervention strategies for heat adaptation.

PI_NAMEs: SCHINASI, LEAH H (contact)

PROGRAM_OFFICER_NAME: PUGGAL, MONA A

PROJECT_TERMS: Acute;Age;Aging;American;Behavior;Biological;built environment;Cardiovascular Diseases;Cardiovascular system;Categories;Cause of Death;Censuses;Cessation of life;Characteristics;Chronic;Climate;climate change;climate zone;cohort;Communities;cost;Cox Proportional Hazards Models;Data;Data Set;design;econometrics;effective intervention;Elderly;enhancing factor;Environment;Equilibrium;Europe;Event;extreme heat;flexibility;follow-up;Future;future climate scenario;Goals;greenhouse gases;Health;Health protection;Heat Waves;Household;Housing;human old age (65+);Humidity;improved;indexing;Individual;Intervention;Kidney Diseases;Knowledge;land cover;Link;Longitudinal cohort study;Longitudinal Studies;Measures;Medicare;Meta-Analysis;meteorological data;Modeling;models and simulation;Morbidity - disease rate;mortality;mortality disparity;Neighborhoods;older adult;Outcome;Participant;Persons;Physics;population based;Predisposition;premature;prevent;Probability;Quasi-experiment;Research;residence;Resolution;respiratory;Respiratory Disease;Risk;Savings;Seasons;Selection Bias;social;sociodemographics;Subgroup;synergism;Temperature;therapy design;Time;Typology;Uncertainty;United States;Urbanicity;Urbanization;Weather;Work

PROJECT_TITLE: The housing environment and ambient temperature (HEAT) study

STUDY_SECTION: SSPB

STUDY_SECTION_NAME: Social Sciences and Population Studies B Study Section[SSPB]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Hematology;Human Genome;Infectious Diseases;Lymphatic Research;Lymphoma;Rare Diseases

ORG_CITY: NEW ORLEANS

ORG_DEPT: PATHOLOGY

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: Project narrative EBV lytic replication contributes to EBV associated lymphoma in the HIV setting. Here we will study new models for virus-cell interactions that play a role in subverting the host cell environment to achieve high-level production of viral packaging proteins and infectious particles; aspects of the viral infection cycle that contributes to viral spread and EBV/HIV associated malignancies.

PI_NAMEs: FLEMINGTON, ERIK K (contact)

PROGRAM_OFFICER_NAME: READ-CONNOLE, ELIZABETH LEE

PROJECT_TERMS: AIDS population;AIDS related cancer;Architecture;Automobile Driving;Binding;Binding Sites;Biological Models;cell growth regulation;Cell Nucleus;Cells;Chromatin;co-infection;Complex;Cues;Cytoplasm;Data;Dedications;Direct Lytic Factors;DNA Polymerase II;DNA Tumor Viruses;Down-Regulation;Environment;Epstein-Barr Virus-Related Lymphoma;Epstein-Barr Virus-Related Malignant Neoplasm;Fostering;Frequencies;gammaherpesvirus;Gene Expression;Genes;Genetic;Genetic Transcription;Genome;Genomics;Herpesviridae;high volume manufacturing;HIV;HIV/AIDS;Human Herpesvirus 4;Human Herpesvirus 8;humanized mouse;Incidence;Individual;insight;Link;Lymphoma;Lymphomagenesis;Lytic;lytic replication;Mediating;Messenger RNA;Metabolism;Modeling;mouse model;mRNA Expression;mRNA Transcript Degradation;Mus;Nature;particle;Pathway interactions;Population;Positioning Attribute;Predisposition;Process;Production;programs;promoter;Proteins;Resources;response;RNA;RNA-Binding Proteins;Role;Site;Specific qualifier value;Stimulus;Structural Protein;therapeutic target;Trans-Activators;Transcript;transcription factor;Transcription Initiation;transcriptome;Translations;Viral;Viral Packaging;Viral Proteins;Viral Structural Proteins;Virion;Virus;Virus Diseases;virus host interaction;Virus Latency;Virus Replication;Virus-Cell Membrane Interaction

PROJECT_TITLE: EBV reactivation causes widespread host de novo promoter transcription and transcriptional interference

STUDY_SECTION: HCAC

STUDY_SECTION_NAME: HIV Coinfections and HIV Associated Cancers Study Section[HCAC]


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Precision Medicine

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: PROJECT NARRATIVE The bioinformatics resource for generating and analyzing cancer functional proteomic data proposed in this application is relevant to public health because it will greatly help biomedical researchers understand the molecular mechanisms and treatment responses of human cancers, thereby facilitating the development and implementation of precision cancer medicine. Thus, this project is relevant to the NIH mission to develop fundamental knowledge that will reduce the burden of illness and disability.

PI_NAMEs: AKBANI, REHAN ;LIANG, HAN  (contact);MILLS, GORDON B.

PROGRAM_OFFICER_NAME: PATRIOTIS, CHRISTOS F

PROJECT_TERMS: Acceleration;Activities of Daily Living;Animal Model;anti-cancer research;Antibodies;Apoptosis;Atlases;bioinformatics resource;Biological Markers;biomarker validation;burden of illness;Cancer Center;cancer proteomics;cancer therapy;cBioPortal;Cell Cycle;Cell Line;Clinical;Clinical Trials;Communities;Complex;Computer software;computerized data processing;cost effective;Data;data quality;data repository;Data Set;Databases;Dedications;Development;disability;DNA Damage;Documentation;Drug Targeting;Educational workshop;experience;Feedback;FRAP1 gene;Functional disorder;Generations;Genome;Goals;Human;Immune;improved;Individual;Internet;Journals;Knowledge;Letters;Link;Literature;Malignant Neoplasms;MAP Kinase Gene;Memorial Sloan-Kettering Cancer Center;Mining;Mission;Molecular;multidisciplinary;Outcome;Paper;patient derived xenograft model;Patients;Performance;Phase;PIK3CG gene;Precision cancer therapy;precision oncology;prognostic;Protein Array;protein biomarkers;Proteins;Proteome;Proteomics;Public Health;Quality Control;Reference Standards;Reproducibility;Research Personnel;Resistance;Sampling;Signal Pathway;Site;Software Engineering;success;Synapses;Technology;The Cancer Genome Atlas;Therapeutic;Therapy Evaluation;therapy resistant;tool;Transforming Growth Factor beta;Translations;treatment response;United States National Institutes of Health;University of Texas M D Anderson Cancer Center;user-friendly;Visualization;web platform;Writing;Xenograft Model

PROJECT_TITLE: The Cancer Proteome Atlas: an Integrated Bioinformatics Resource for Functional Cancer Proteomic Data


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Heart Disease;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_DEPT: BIOMEDICAL ENGINEERING

PHR: PROJECT NARRATIVE Cardiomyocytes sense internal and external physical cues to regulate mechanical homeostasis during the force generating cardiac cycle, and the focal adhesions are mechanosensitive structures that are important for both cardiomyocyte attachment to the extracellular matrix and maturation of the contractile apparatus. However, little is known about the specific spatial distribution of tension generation across the focal adhesions during cardiomyocyte contraction and the dependence of this tension on inherent cardiomyocyte contractile ability. This work seeks to utilize cutting edge molecular force sensor technology in stem cell derived cardiomyocytes to (1) study the spatial and temporal physiological focal adhesion tension during static and dynamic cardiomyocyte contraction and (2) determine the internal and external regulation of focal adhesion tension in cardiomyocytes through modulation of the contractile force and substrate attachment.

PI_NAMEs: NAGLE, ABIGAIL  (contact)

PROJECT_TERMS: Adhesions;Adhesives;Adrenergic Agents;Adrenergic beta-Agonists;Area;Calcium;Cardiac;Cardiac Myocytes;Cardiac Output;Cell Adhesion;Cell Physiology;cell type;Cells;Cellular Structures;Characteristics;citrate carrier;Complex;Contracts;Cues;Cytoskeleton;Data;data acquisition;Dependence;Distal;Energy Transfer;Engineering;Esthesia;experience;extracellular;Extracellular Matrix;Feedback;fighting;Focal Adhesions;force sensor;Future;Generations;Geometry;Heart Diseases;Heterogeneity;Homeostasis;Image Analysis;Individual;induced pluripotent stem cell;induced pluripotent stem cell derived cardiomyocytes;Investigation;Isoproterenol;Knowledge;Location;Measurement;Measures;mechanical drive;mechanical signal;Mechanics;mechanotransduction;Mediating;Microfilaments;Microscopy;Modeling;Molecular;Morphologic artifacts;Muscle Cells;mutant;Myofibrils;overexpression;Pathway interactions;Pattern;Physiological;Physiology;Positioning Attribute;Property;protein complex;Proteins;Regulation;Relaxation;response;RGD (sequence);Role;Sarcomeres;sensor;sensor technology;Signal Transduction;Spatial Distribution;stem cells;Stress;Structure;targeted treatment;Techniques;Thin Filament;Time;tool;Traction;Troponin C;VCL gene;Vinculin;Work

PROJECT_TITLE: An Investigation of Focal Adhesion Tension During Cardiomyocyte Contraction


NIH_SPENDING_CATS: Cancer;Genetics;Hematology;Infectious Diseases;Lymphatic Research;Lymphoma;Orphan Drug;Rare Diseases

ORG_DEPT: GENETICS

PHR: PROJECT NARRATIVE Epstein-Barr virus regulates cellular metabolism to control B-cell proliferation and promote lymphomas. These studies will define the molecular mechanisms underlying how EBV controls B-cell metabolism.

PI_NAMEs: LUFTIG, MICAH A. (contact)

PROGRAM_OFFICER_NAME: HOWCROFT, THOMAS K

PROJECT_TERMS: Address;Adult;antagonist;B Cell Proliferation;B lymphocyte immortalization;B-Cell Lymphomas;B-Lymphocytes;Biochemical;Biogenesis;c-myc Genes;cell growth;cell growth regulation;Cell Proliferation;cell transformation;Cells;Cellular Metabolic Process;Collagen;Complex;Data;Disease;Enzymes;Epithelial Cells;Epstein-Barr Virus Infections;Epstein-Barr Virus latency;Equilibrium;Family;functional mimics;gammaherpesvirus;Genetic;Glutathione;Glycolysis;Glycolysis Induction;Goals;Herpesviridae;Human;Human Herpesvirus 4;Human Herpesvirus 8;Immune;Immune response;In Vitro;in vivo;infected B cell;Infection;innovation;Lactate Transporter;latent infection;Leucine;LMP1;lymphoblastoid cell line;Lymphoma;Lymphomagenesis;Lytic;Lytic Phase;Mediating;Metabolic;Metabolic Control;Metabolism;mimicry;Mitochondria;Modality;Modeling;Molecular;mouse model;NADH;neurotensin mimic 1;novel;novel therapeutics;nrf1 protein;oral cavity epithelium;Outcome;Oxidation-Reduction;Oxidative Phosphorylation;Pathway interactions;Post-Translational Protein Processing;pre-clinical;Proliferating;Proline;Proteins;Reactive Oxygen Species;Regulation;Research;Role;Saliva;Supporting Cell;T-Lymphocyte;Testing;Therapeutic;Transcription Coactivator;transcription factor;Transcriptional Activation;transmission process;tumorigenesis;Untranslated RNA;Up-Regulation;Viral;virtual;Virus;Virus Latency;Work

PROJECT_TITLE: Host pathways regulating Epstein-Barr virus-mediated B cell growth transformation


NIH_SPENDING_CATS: Behavioral and Social Science;Bipolar Disorder;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Neurosciences;Precision Medicine;Psychosis;Schizophrenia;Serious Mental Illness

ORG_CITY: BOSTON

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: Narrative In this proposal, we will characterize the trajectories of outcome in early course psychotic disorders treated in coordinated specialty care programs. We will also identify clinical and biological features, and biological subtypes of psychotic disorders that may help predict outcome.

PI_NAMEs: KESHAVAN, MATCHERI S. (contact)

PROGRAM_OFFICER_NAME: RUDORFER, MATTHEW V

PROJECT_TERMS: Accounting;Age Years;Biological;Biological Markers;biomarker development;biomarker identification;biotypes;Bipolar Disorder;Boston;care outcomes;care systems;Categories;Chronic;Clinic;Clinical;clinical practice;clinical predictors;Cognition;Cognitive;cognitive function;Communities;community setting;Coordinated Specialty Care;cost;Data;Data Collection;design;Diagnosis;Diagnostic;Dimensions;Disease remission;early detection biomarkers;Early Intervention;early psychosis;early satiety;Electroencephalography;Enrollment;Eye Movements;follow-up;functional decline;functional outcomes;Funding;Goals;Grant;Heterogeneity;Image;imaging biomarker;Impaired cognition;Impairment;improved;improved outcome;Individual;individual variation;Intervention;Measures;medical specialties;meetings;Modeling;Multivariate Analysis;Neurobiology;Neurocognition;Neurocognitive;neuroimaging;Neurosciences Research;Onset of illness;Outcome;outcome prediction;Participant;Patients;pharmacologic;Phenotype;phenotypic biomarker;Population;Population Characteristics;prediction algorithm;Predictive Value;Procedures;prognostic value;programs;Psychoses;psychosocial;psychotic;Psychotic Disorders;Recovery;recruit;Resources;response;Sampling;Schizoaffective Disorders;Schizophrenia;Schizophreniform Disorder;Services;Site;Stimulus;Structure;Subgroup;Substance abuse problem;success;Testing;Therapeutic Intervention;therapy resistant;Time;treatment adherence;treatment planning;treatment program;Variant

PROJECT_TITLE: Biomarkers/Biotypes, Course of Early Psychosis and Specialty Services (BICEPS)


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

ORG_CITY: ATHENS

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF GEORGIA

ORG_STATE: GA

PI_NAMEs: CLEMENTZ, BRETT A (contact)

PROJECT_TITLE: 5/5 - Biomarkers/Biotypes, Course of Early Psychosis and Specialty Services (BICEPS)


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Back Pain;Basic Behavioral and Social Science;Behavioral and Social Science;Chronic Pain;Clinical Research;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pain Research;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: SAINT LOUIS

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

PHR: Revised Public Health Relevance Statement  The impact of social stressors such as economic hardships, inter-personal violence, social isolation, unstable access to healthcare, and other major life events/daily hassles on the progression of chronic low back pain (cLBP) remains poorly understood. The goal of this project is to elucidate the influence of social stressors, and their biological consequences (i.e., allostatic load), on cLBP by prospectively assessing the two-year progression of clinical pain and disability among people residing in the greater St. Louis MO and Nashville TN metropolitan areas.

PI_NAMEs: GOODIN, BUREL R. (contact)

PROGRAM_OFFICER_NAME: LINARES, DEBORAH ELIZABETH

PROJECT_TERMS: Acute;Address;Adult;adverse childhood events;Adverse effects;allostatic load;Anxiety;Attitude;Biological;Black Populations;Black race;Blood Pressure;C-reactive protein;Cardiovascular system;Cessation of life;Chronic;Chronic low back pain;chronic pain;Clinical;clinical pain;clinical predictors;COVID-19;COVID-19 pandemic;Data;depressive symptoms;disability;Disabling condition;Discrimination;Disease;Disparity;Disparity population;Distress;Equation;Event;experience;Exposure to;follow-up;Follow-Up Studies;Friends;Funding;Glycosylated hemoglobin A;Goals;Group Affiliation;Health;health care availability;Hydrocortisone;Immune;improved;Individual;Life;Literature;Loneliness;loved ones;Low Back Pain;low socioeconomic status;Measures;Metabolic;Minority Groups;minority stress;Modeling;Neurosecretory Systems;Not Hispanic or Latino;optimism;Pain;pain inhibition;Pain management;pain sensitivity;pain symptom;Pathology;Pattern;peer;perceived stress;Persistent pain;Persons;Physiological;Prevalence;Primary Care Physician;promote resilience;prospective;psychologic;psychological distress;psychosocial;Psychosocial Factor;Race;racial determinant;racial difference;racial discrimination;racial disparity;racial identity;racial population;racism;Reporting;Research;resilience factor;Rest;Risk Factors;Sensory;Severities;social determinants;social influence;Social isolation;social stress;social stressor;Social support;Socialization;Socioeconomic Status;socioeconomics;Spirituality;Stigmatization;Stress;Stressful Event;Symptoms;Testing;theories;Time;Tissues;Vertebral column;Violence;Visit;Work

PROJECT_TITLE: Racial and Socioeconomic Differences in Chronic Low Back Pain

STUDY_SECTION: BMHO

STUDY_SECTION_NAME: Biobehavioral Medicine and Health Outcomes Study Section[BMHO]


ORG_DEPT: CHEMISTRY

ORG_NAME: NORTHEASTERN UNIVERSITY

PHR: Project Narrative Mutated KRAS is a highly prevalent oncoprotein driving a number of cancers, including forms of lung, pancreatic, and colorectal cancers, but it has not been successfully inhibited using traditional pharmacological approaches despite over thirty years of research. Here, we propose a DNA-based therapeutic agent, which works by preventing the mutated KRAS from being produced in the first place. Although preliminary data already suggest the effectiveness of this agent in a mouse model, we aim to gain a deeper understanding about its cell biology and more confidence regarding its efficacy in advanced preclinical models through this proposal, with the goal of translating it into the clinic.

PI_NAMEs: ZHANG, KE  (contact)

PROGRAM_OFFICER_NAME: GREENBERG, WILLIAM A

PROJECT_TERMS: Acceleration;acute toxicity;Address;alternative treatment;Animal Cancer Model;Animal Model;Antisense Oligonucleotides;Architecture;Area Under Curve;Automobile Driving;Binding;Biodistribution;Biological Products;biological systems;Blood Coagulation Disorders;cancer cell;Cancer cell line;Cancer Model;Cell Proliferation;Cells;Cellular biology;Characteristics;Chemicals;Chemistry;Clinic;Clinical;Clinical Research;Colorectal Cancer;Data;Deoxyribonucleases;Development;DNA;dosage;Drug Kinetics;Effectiveness;ethylene glycol;Exhibits;Gene Expression Regulation;Genes;Genetically Engineered Mouse;Goals;Half-Life;Human;Immune system;Immunologic Stimulation;improved;in vivo;Inflammation;inhibitor;insight;Intracellular Transport;intravenous administration;Investigation;Kidney;knock-down;Liver;Lung Adenocarcinoma;lung cancer cell;Malignant neoplasm of lung;Malignant neoplasm of pancreas;Malignant Neoplasms;Mediating;MEKs;Messenger RNA;Methods;Modality;Modeling;mouse model;Mus;mutant;Mutate;Mutation;nanoparticle;neoplastic cell;Non-Small-Cell Lung Carcinoma;novel;nucleic acid-based therapeutics;Nucleic Acids;oligonucleotide therapeutics;Oligonucleotides;Oncogenes;Oncogenic;Oncoproteins;Outcome;patient derived xenograft model;Patients;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;pharmacologic;Pharmacologic Substance;Pharmacology;Plasma;Polyethylene Glycols;Polymers;pre-clinical;Pre-Clinical Model;prevent;Property;Proteins;RAS Family Gene;Rattus;Refractory;Research;Ribonuclease H;Safety;Sarcoma;Side;side effect;Signal Pathway;Signal Transduction;single molecule;small molecule;small molecule inhibitor;stem;Structure;subcutaneous;Therapeutic Agents;therapeutic DNA;Therapeutic Intervention;three dimensional cell culture;three-dimensional modeling;Toll-like receptors;Toxic effect;trafficking;Translating;Translational Repression;Translations;treatment strategy;tumor;tumor microenvironment;Tumor Suppression;uptake;Validation;Viral Oncogene;Work;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Targeting Oncogenic KRAS with Brush-Architectured Poly(ethylene glycol)-DNA Conjugates

STUDY_SECTION: GDD

STUDY_SECTION_NAME: Gene and Drug Delivery Systems Study Section[GDD]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Infectious Diseases;Lung;Rare Diseases;Social Determinants of Health;Tuberculosis

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: In endemic countries, most TB disease is due to recently acquired infection with M. tuberculosis (Mtb) and reducing transmission events is essential for control of the epidemic. We will use a household contact study design to develop novel aerobiology and immunology tools to examine mechanisms of Mtb transmission. Understanding Mtb transmission could lead to insights into pathogenesis and the development of novel intervention strategies.

PI_NAMEs: HAWN, THOMAS R;HORNE, DAVID J. (contact)

PROGRAM_OFFICER_NAME: LACOURCIERE, KAREN A

PROJECT_TERMS: Address;aerosolized;Aerosols;Area;Biological;Biological Assay;Biological Markers;case finding;Categories;Characteristics;Communities;Community Surveys;community transmission;community-level factor;Coughing;Country;Data;demographics;design;Development;digital;Disease;Disease Progression;Enrollment;Epidemic;epidemic response;Epidemiology;Evaluation;Event;Exposure to;follow-up;Frequencies;Gene Expression Profile;Genetic Transcription;Geographic Locations;health care availability;Healthcare;Heterogeneity;High Prevalence;high risk;HIV;Household;Immunogenetics;Immunologics;Immunology;improved;indexing;Individual;individual responsibility;Infection;Infection prevention;innovation;insight;interdisciplinary approach;Interferon Type II;Interruption;Intervention;Investigation;Kenya;Knowledge;Link;male;Measurement;Methods;migration;Minority;Mycobacterium tuberculosis;Neighborhoods;Newly Diagnosed;novel;Pathogenesis;Patients;peripheral blood;Phenotype;population based;Predisposition;Prevalence;programs;Public Health;Publishing;Pulmonary Tuberculosis;Research;Research Design;Resistance;Resource Allocation;Resources;response;Risk;Risk Factors;Sampling;Sputum;Surveys;System;Time trend;tool;transcriptome sequencing;transmission process;Tuberculosis;urban area;Variant;ventilation;young man

PROJECT_TITLE: Aerobiology, immunology, and Mycobacterium tuberculosis transmission

STUDY_SECTION: CRFS

STUDY_SECTION_NAME: Clinical Research and Field Studies of Infectious Diseases Study Section[CRFS]


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Clinical Research;Immunotherapy;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: CHICAGO

ORG_DEPT: NEUROSURGERY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: Narrative Although anti-PD-1 treatment has shown efficacy against brain metastases indicating that the blood-brain-barrier is not an impediment to immunotherapy, clinical trial results of anti-PD-1 in glioblastoma patients have been disappointing with only a subset of patients likely benefiting. Glioblastomas typically have minimal tumor T cell infiltration but are highly infiltrated with macrophages and microglia that express PD-1. This proposal will clarify which immune cells that anti-PD-1 antibodies engage, how this interaction modulates anti-tumor immune reactivity in the setting of lymphopenia, and if these therapeutics gain access into the central nervous system tumor microenvironment.

PI_NAMEs: HEIMBERGER, AMY BETH (contact);RAO, GANESH

PROGRAM_OFFICER_NAME: SINGH, ANJU

PROJECT_TERMS: Adaptive Immune System;Address;Affect;Animal Model;anti-PD-1;anti-PD1 antibodies;anti-PD1 therapy;Area;arm;Biological Markers;Blood - brain barrier anatomy;Bone Marrow;cancer infiltrating T cells;cancer therapy;Cd68;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Communication;Cells;Central Nervous System;Central Nervous System Neoplasms;checkpoint inhibition;chemokine;clinical predictors;Clinical Trials;cytotoxic;Data;Effector Cell;effector T cell;exhaust;Exposure to;Failure;Frequencies;Genetically Engineered Mouse;Glioblastoma;Glioma;Gliomagenesis;Human;human data;human subject;Immune;immune checkpoint;Immune checkpoint inhibitor;immune function;immune modulating agents;Immune response;Immunologic Surveillance;Immunologics;Immunology;immunoregulation;Immunosuppression;Immunotherapy;in vivo;Infiltration;Innate Immune System;Intravenous;intravenous administration;Knock-out;Ligands;Lymphopenia;Macrophage;Malignant Glioma;Malignant Neoplasms;Mediating;Metastatic malignant neoplasm to brain;Metastatic Neoplasm to the Central Nervous System;Microglia;Modeling;monocyte;mouse model;Mus;Myelogenous;Natural Immunity;osteopontin;patient subsets;Patients;Peripheral;Phenotype;Population;Primary Brain Neoplasms;programmed cell death protein 1;Property;recruit;response;restraint;Role;Secondary to;STAT3 gene;synergism;T cell response;T-Lymphocyte;Testing;Therapeutic;Therapeutic Effect;Treatment Efficacy;treatment response;tumor;tumor microenvironment;tumor progression;Tumor Promotion;tumor-immune system interactions;Tumor-infiltrating immune cells;Undifferentiated;Validation;Wild Type Mouse;Work

PROJECT_TITLE: Modulation of Microglia and T Cell Interactions in Malignant Glioma

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


PHR: PROJECT NARRATIVE A large number of human diseases can affect the structure and function of blood vessels in the lung. In fact, when diseases are complicated by increases in pressure in the lung blood vessels (lung vascular disease), significant increases in morbidity and mortality are observed, which are often due to dysfunction or failure of the right heart. This program is directed at training individuals to better understand the causes of lung vascular and right heart disease with the long-term goal that these investigators will develop new therapies to decrease or ameliorate the health burden of lung vascular problems.

PI_NAMEs: FLORES, SONIA CASTRO;LAHM, TIM ;STENMARK, KURT R. (contact)

PROGRAM_OFFICER_NAME: KALANTARI, ROYA

PROJECT_TERMS: Biology;Blood Vessels;Lung;programs

PROJECT_TITLE: Translational Pulmonary Vascular Biology Program


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Breast Cancer;Cancer;Gene Therapy;Genetics;Immunotherapy;Women's Health Research

ORG_CITY: ATLANTA

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: GEORGIA INSTITUTE OF TECHNOLOGY

PHR: Project Narrative To enhance CAR T cells for solid tumors, potent immunomodulators such as cytokines or bispecific T cell engagers (BTEs) can be co-infused. However, systemic delivery of these agents breaches self-tolerance resulting in numerous immune related adverse effects. This proposal seeks to use focused ultrasound to non- invasively control the intratumoral production of BTEs by thermal sensitive CAR T cells to enhance anti-tumor activity and elucidate mechanisms of epitope spread by investigating DC priming of endogenous T cells.

PI_NAMEs: ZAMAT, ALI  (contact)

PROGRAM_OFFICER_NAME: PURI, ANU

PROJECT_TERMS: Adoptive Cell Transfers;Adverse event;Antibodies;Antigen Targeting;Antigens;Antitumor Response;Autoimmunity;bi-specific T cell engager;Body Temperature;Breast Cancer Model;cancer type;CAR T cell therapy;CD3 Antigens;cell killing;Cell Physiology;Cells;chimeric antigen receptor;chimeric antigen receptor T cells;Clinical;clinical care;Continuous Infusion;cytokine;cytokine release syndrome;cytotoxicity;delivery vehicle;Deposition;design;Diffusion;Diphtheria Toxin;Drug Delivery Systems;Drug Kinetics;Effectiveness;engineered T cells;Epitope spreading;Epitopes;ERBB2 gene;Exposure to;FDA approved;FLT3 ligand;Focused Ultrasound;Genetic Transcription;Half-Life;Heating;Hematologic Neoplasms;Human;Image;Immune;immune cell infiltrate;Immune response;Immune system;immune-related adverse events;Immunity;Immunocompetent;Immunological Models;Immunomodulators;Immunophenotyping;immunoregulation;improved;In Vitro;in vivo;Infiltration;Investigation;Life;Ligands;Local Hyperthermia;long term memory;lymph nodes;Malignant Breast Neoplasm;Malignant Neoplasms;Measurement;Measures;Mediating;member;migration;mouse model;Mus;Natural Killer Cells;neoplastic cell;neurotoxicity;overexpression;Patients;peripheral blood;pre-clinical;preclinical evaluation;Production;Prognosis;Proliferating;receptor;Recurrent disease;Reporting;response;Rest;Self Tolerance;Site;Solid Neoplasm;Specificity;Spleen;Stress;success;Surveys;Switch Genes;Systemic Therapy;T cell therapy;T-Cell Activation;T-Lymphocyte;Techniques;therapeutic target;Tissues;Toxic effect;transgene expression;Transgenes;Transgenic Mice;Trastuzumab;treatment response;tumor;Tumor Antigens;Tumor Burden;Tumor Escape;Tumor Immunity;Ultrasonic wave

PROJECT_TITLE: Focused ultrasound control of intratumoral NKG2DL BTE production by CART cells to potentiate epitope spread


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Lung;Lung Cancer;Orphan Drug;Rare Diseases

ORG_NAME: FRED HUTCHINSON CANCER CENTER

PHR: Project Narrative Small cell lung cancer (SCLC) patients tend to respond remarkably well to chemotherapy, but, through largely unknown mechanisms, chemoresistance rapidly emerges. We found that single gene perturbation of chemosensitive patient derived xenograft models of SCLC can confer switch to chemoresistance and we took advantage of this finding to perform in vivo functional screens. This proposal is focused on understanding a pathway that emerged from our screens that, when suppressed, potently drive SCLC chemoresistance in vivo.

PI_NAMEs: MACPHERSON, DAVID  (contact)

PROGRAM_OFFICER_NAME: JOHNSON, RONALD L

PROJECT_TERMS: Bromodeoxyuridine;Cancer cell line;Cancer Patient;cancer type;Cell Death;Chemoresistance;chemotherapy;Chromatin;Cisplatin;Cleavage Under Targets and Release Using Nuclease;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;Data;DNA Damage;epigenetic silencing;established cell line;Etoposide;Family member;Gene Targeting;Genes;Genetic;genetic manipulation;Genetic Transcription;Genomics;Histone H3;histone modification;Human;In Situ Nick-End Labeling;In Vitro;in vivo;insight;Kinetics;Knowledge;lentivirally transduced;Libraries;lung cancer cell;Malignant neoplasm of lung;member;Modeling;Molecular;Mus;mutant;Mutation;MYCL1 gene;MYCN gene;Neurosecretory Systems;novel;overexpression;Parents;Pathway interactions;patient derived xenograft model;patient response;Patients;Pharmaceutical Preparations;Phosphorylation;prevent;Process;Proliferating;Proteins;Proteomics;Refractory;Relapse;Resistance;response;RNA analysis;Role;SAGA;screening;small cell lung carcinoma;System;Testing;tissue culture;Tissues;transcriptome sequencing;treatment response;tumor growth

PROJECT_TITLE: Identifying and understanding drivers of chemoresistance in small cell lung cancer

STUDY_SECTION: MCTB

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics B Study Section[MCTB]