NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);American Indian or Alaska Native;Arctic;Brain Disorders;Clinical Research;Dementia;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research

PI_NAMEs: KAUWE, JOHN SAI KEONG (contact)

PROJECT_TERMS: Address;Alaska Native;Alleles;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;American Indians;Area;biobank;Bioinformatics;Biological;Biological Assay;Biological Markers;Blood specimen;Blood Tests;Brain;Cataloging;Cognition;cohort;Collaborations;Collection;Communication;Communities;Community Participation;Consent;cultural values;Data;Data Set;data sharing;Databases;Dementia;dementia risk;design;Disease;Disease Marker;Disparity;DNA;Educational workshop;Enrollment;Ensure;Ethnic Origin;Ethnic Population;Faculty;Future;Genes;Genetic;Genetic Research;genetic resource;Genetic Risk;genetic risk factor;Genetic study;Genetic Variation;genome sequencing;Genomics;Genotype;Geographic Distribution;Guam;Health;Indigenous;indigenous community;International;Knowledge;Learning;Link;Literature;Magnetic Resonance Imaging;member;Memory;Minority;National Institute on Aging;Native Hawaiian;Native Hawaiian or Other Pacific Islander;Native-Born;natives;Ownership;Participant;Patient Self-Report;Persons;polygenic risk score;Population;Process;racial disparity;racial population;recruit;Regulation;remediation;Reporting;repository;Research;Research Personnel;Research Project Grants;Resources;saliva sample;Sampling;Satellite Centers;Scientist;Site;Source;Spinal Tap;Testing;Training;Universities;Variant;whole genome;Work

PROJECT_TITLE: Biospecimen Core


ADMINISTERING_IC: EY

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Autoimmune Disease;Brain Disorders;Clinical Research;Eye Disease and Disorders of Vision;Multiple Sclerosis;Neurodegenerative;Neurosciences

ORG_CITY: IOWA CITY

ORG_COUNTRY: UNITED STATES

ORG_DEPT: OPHTHALMOLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Project Narrative  Optic neuritis (ON) is a common manifestation of auto-immune demyelinating disorders such as multiple sclerosis (MS) and frequently results in visual impairment or permanent vision loss. Our understanding of the contribution of cholesterol homeostasis to MS-related ON pathology and repair is limited by the lack of detailed mechanistic insight into the dual role of cholesterol synthesis and transport in the retinogeniculate system. This proposal will use eye and brain organoids obtained from induced pluripotent stem cells of MS patients, MS donor eye tissue and in vivo models of ON to determine that restoration of cholesterol homeostasis ameliorates structural and functional impairment in MS-like ON and is a viable approach for future translational and therapeutic investigations.

PI_NAMEs: GRAMLICH, OLIVER W (contact)

PROGRAM_OFFICER_NAME: HENLE, STEVEN JOHN

PROJECT_TERMS: 3-Dimensional;Acids;Acute;Affect;Agonist;Animal Experimentation;Animal Model;Animals;Aspirin;ATP binding cassette transporter 1;Autoimmune;Autopsy;Axon;Biological Assay;Blindness;Brain;Carrier Proteins;Cell Line;Cell Survival;cell type;Cells;Central Nervous System;central nervous system demyelinating disorder;Cholesterol;Cholesterol Homeostasis;Data;Demyelinating Diseases;Demyelinations;Development;Disease;Dyes;Electroretinography;Event;experience;Experimental Autoimmune Encephalomyelitis;experimental study;Exposure to;Eye;Feedback;Functional impairment;Future;Goals;Harvest;Healthcare Systems;Human;Immunohistochemistry;Impairment;improved;In Vitro;in vivo;in vivo Model;induced pluripotent stem cell;Infiltration;Inflammation;Inflammatory;inhibitor;Injury;innovation;insight;Interferon Type II;Investigation;Lysophosphatidylcholines;Mediating;mevalonate;Modeling;Molecular;Molecular Biology;Multiple Sclerosis;multiple sclerosis patient;Mus;Myelin;myelination;Nerve Tissue;neuronal survival;Neurons;neuroprotection;novel therapeutics;Oligodendroglia;Ophthalmology;Optic Nerve;Optic Neuritis;Optical Coherence Tomography;Organoids;Outcome;Outcome Measure;Pathology;Pathway interactions;Patients;Pattern;preservation;Prevalence;prevent;Process;Recovery;Recovery of Function;Recycling;regenerative;remyelination;repaired;Reporter;Resources;response;restoration;Retina;retinal ganglion cell degeneration;Retinal Ganglion Cells;retinogeniculate;reverse cholesterol transport;Role;single-cell RNA sequencing;social;Sterols;success;Synaptic plasticity;synaptogenesis;System;Systems Biology;targeted treatment;Testing;Therapeutic;Therapeutic Studies;Time;Tissues;TNF gene;transcriptome sequencing;translational study;uptake;Vision;Visual evoked cortical potential;Visual impairment

PROJECT_TITLE: Targeting Cholesterol Homeostasis to maintain vision in MS-like optic neuritis

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);American Indian or Alaska Native;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurodegenerative;Neurosciences;Primary Health Care;Racial and Ethnic Minority Health Research

ORG_CITY: PULLMAN

ORG_NAME: WASHINGTON STATE UNIVERSITY

ORG_STATE: WA

PI_NAMEs: JOHANSSON, PATRIK LENNART (contact)

PROJECT_TERMS: Academy;aged;Alaska Native;Alaska Native population;Alzheimer's Disease;Alzheimer's disease care;Alzheimer's disease related dementia;Alzheimer's disease risk;American;American College of Physicians;American Indian Population;American Indians;antagonist;anti-depressive agents;Behavior;care outcomes;Caregiver support;Caring;Cholinesterase Inhibitors;Chronic;Clinic;cognitive testing;common treatment;Communities;Complex;Computerized Medical Record;Current Procedural Terminology Codes;Data;Dementia;dementia care;design;Diagnosis;Education;Elderly;Electronic Health Record;Elements;Evaluation;Family;follow-up;Fostering;Friends;Geriatric Assessment;Geriatrics;Health;Health Personnel;Health Professional;Health Services;health training;Healthcare;Healthcare Systems;human old age (65+);Impaired cognition;improved;informant;innovation;Intervention;Interview;Knowledge;Managed Care;medical specialties;Medicare;mild cognitive impairment;N-Methylaspartate;native elder;natives;Neuropsychology;Newly Diagnosed;Outcome;Outcome Measure;Pamphlets;Patient Education;Patient Self-Report;Patients;Pharmaceutical Preparations;Population;Population Projection;pragmatic trial;Primary Care;Primary Care Physician;Primary Health Care;Privatization;programs;Quality of Care;Questionnaires;racial population;Randomized;randomized trial;rapid growth;Research;Research Project Grants;Reservations;Resources;Rural;rural health clinic;rural setting;screening;Services;Site;skills;Societies;symposium;System;Testing;Training;Training and Education;trend;Tribes;United States Dept. of Health and Human Services;United States Indian Health Service;urban Native American;Waiting Lists

PROJECT_TITLE: Indian Transforming Alzheimer's Care Training


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: ANN ARBOR

ORG_DEPT: BIOPHYSICS

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative MicroRNAs are important post-transcriptional regulators of gene expression and their mis-regulation has been linked to numerous diseases. The research program proposed here aims to provide insight into the structural and biochemical basis underlying the precise regulation of microRNA biogenesis. A better understanding of the structures, dynamics, and effector proteins regulating microRNA production is necessary for the development of targeted therapeutics to treat diseases linked to the dysregulated gene expression by microRNAs.

PI_NAMEs: KEANE, SARAH COURTNEY (contact)

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TERMS: Area;Binding Proteins;Biochemical;Biogenesis;Biological;Biological Process;Biophysics;Cells;Chemicals;Complex;Development;Diabetes Mellitus;Disease;Elements;Eukaryota;Eukaryotic Cell;Family;Family member;Gene Expression;genetic regulatory protein;Goals;Heart Diseases;Human;insight;Link;Malignant Neoplasms;Mediating;member;Messenger RNA;Methodology;MicroRNAs;Modification;Molecular;Neurodegenerative Disorders;novel;Post-Transcriptional Regulation;posttranscriptional;Production;programs;Proteins;Regulation;Regulator Genes;Research;RNA;RNA Folding;RNA-targeting therapy;Structure;targeted treatment;Untranslated RNA

PROJECT_TITLE: Biophysics of Regulatory RNAs and RNPs

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-K(55)R]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Clinical Research;Hematology;Lymphatic Research;Lymphoma;Orphan Drug;Precision Medicine;Rare Diseases

ORG_CITY: HOUSTON

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: Narrative  Drug resistance is the main problem to treat mantle cell lymphoma (MCL) and chronic lymphocytic leukemia (CLL). We will develop a novel targeted therapy to treat MCL and CLL. We expect that successful completion of this project will make a significant impact on the treatments of B-cell malignancies.

PI_NAMEs: WANG, JIN  (contact);WANG, MICHAEL ;WOYACH, JENNIFER A.

PROGRAM_OFFICER_NAME: CHEN, WEIWEI

PROJECT_TERMS: Acrylamides;Active Sites;Agammaglobulinaemia tyrosine kinase;Antigen Receptors;Attenuated;B lymphoid malignancy;B-Cell Antigen Receptor;B-Cell Development;B-Lymphocytes;Binding;Biology;Boronic Acids;Calcium;Cell Line;Cells;Chemical Structure;Chemicals;Chemistry;Chronic Lymphocytic Leukemia;chronic lymphocytic leukemia cell;Clinic;Clinical;Clinical Research;commercialization;Complex;covalent bond;Cysteine;design;Development;drug development;drug discovery;Drug resistance;efficacy evaluation;efficacy testing;FDA approved;Goals;Half-Life;improved;In Vitro;in vitro activity;in vitro Assay;in vivo;Industry;inhibitor;kinase inhibitor;Laboratories;Lymphoma;Lymphoma cell;Mantle Cell Lymphoma;MDM2 gene;Methods;Modeling;molecular dynamics;molecular transporter;mouse model;Mus;mutant;Mutation;mutational status;Natural regeneration;new therapeutic target;next generation;novel;novel strategies;Ohio;Oral;Organic Synthesis;Pathway interactions;patient derived xenograft model;Patients;Permeability;Pharmaceutical Preparations;Phase II Clinical Trials;Phosphotransferases;Physicians;Plasma;preclinical efficacy;Property;Proteins;Reaction;Receptor Signaling;recruit;Refractory;Relapse;Reporting;Research;Resistance;resistance mechanism;Scientist;Side;Signal Pathway;small molecule therapeutics;Steroid Receptors;Sulfhydryl Compounds;targeted treatment;Therapeutic Agents;therapeutic evaluation;Therapeutic Intervention;Transgenic Organisms;Treatment Efficacy;Treatment outcome;Tyrosine Kinase Inhibitor;uptake;Work

PROJECT_TITLE: Reversible Covalent BTK Degraders as the Next Generation Targeted Therapy to Treat B-cell Malignancies

STUDY_SECTION: DMP

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology Study Section[DMP]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_CITY: COLD SPRING HARBOR

ORG_NAME: COLD SPRING HARBOR LABORATORY

ORG_STATE: NY

PHR: Project Narrative In vertebrates, olfaction is intrinsically linked to motor action through sniffing, and just as for other sensory modalities, via head and body movements. Due to technical challenges, however, most studies have probed olfactory processing during passive sampling, and even when investigating odor-driven navigation, the effect of movements on odor neural responses has rarely been analyzed. Systematic investigation of the interactions between odor stimuli and sampling movements under closed-loop coupling is essential for understanding how movements and regulate olfactory perception and neural coding at different stages of processing within the mammalian olfactory system.

PI_NAMEs: ALBEANU, DINU FLORENTIN (contact)

PROGRAM_OFFICER_NAME: SABRI, MERAV

PROJECT_TITLE: Understanding the neuronal mechanisms of closed-loop olfaction

STUDY_SECTION: NIC

STUDY_SECTION_NAME: Neuroscience of Interoception and Chemosensation Study Section[NIC]


ADMINISTERING_IC: MH

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Mental Health;Neurosciences

ORG_CITY: CHICAGO

ORG_DEPT: PHYSIOLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative Many psychiatric disorders, including stress-related, affective, autism spectrum, and psychotic disorders, are associated with abnormal learning and memory. This proposal is a request for renewed funding of the predoctoral Neurobiology of Information Storage Training Program to prepare the next generation of scientists to understand, at the most fundamental level, the process of learning and memory and its relevance for mental health.

PI_NAMEs: DOMBECK, DANIEL A (contact)

PROGRAM_OFFICER_NAME: DRISCOLL, JAMIE DANIELLE

PROJECT_TITLE: Training Program in Neurobiology of Information Storage


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cardiovascular;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hypertension;Neurodegenerative;Neurosciences;Nutrition;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

PI_NAMEs: KAHOLOKULA, JOSEPH KEAWE'AIMOKU (contact)

PROJECT_TERMS: Address;Adherence;Adult;African American population;Age;aged;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;American Indians;apolipoprotein E-4;Asian Americans;Biological Specimen Banks;Blood Pressure;Blood Vessels;Cardiovascular Diseases;caucasian American;Cerebrovascular Disorders;clinical care;clinical practice;Cognitive;cognitive change;cognitive function;cognitive performance;cohort;Communities;community organizations;comorbidity;comparison control;Consent;culturally appropriate intervention;Dancing;Data;Dementia;dementia risk;design;Detection;Diabetes Mellitus;Diagnosis;dietary;Dyslipidemias;Early Intervention;Early Onset Alzheimer Disease;Education;Educational Curriculum;Effectiveness;Elderly;Epidemic;ethnic minority;Ethnic Population;Exercise;Functional disorder;Funding;Future;Genes;Genotype;good diet;Hawaii;Health;High Prevalence;high risk;human old age (65+);Hyperglycemia;Hypertension;Impaired cognition;improved;Incidence;indexing;Indigenous;Influentials;Intervention;Intervention Trial;Knowledge;lifestyle intervention;Measurable;Measures;Mental Health;mild cognitive impairment;National Institute on Aging;Native Hawaiian or Other Pacific Islander;natives;Neurobehavioral Manifestations;neuroimaging;novel;Obesity;older adult;Outcome;Participant;Persons;Physical activity;Physical Function;Population;preservation;Prevalence;prevent;Prevention;primary outcome;programs;Protocols documentation;Qualitative Methods;racial minority;racial population;Randomized;randomized trial;Randomized, Controlled Trials;recruit;Research;Research Project Grants;resilience factor;Risk;Risk Factors;Sampling;secondary outcome;social;social engagement;Social support;Source;symposium;Testing;United States National Institutes of Health;vascular risk factor;virtual;Waiting Lists

PROJECT_TITLE: IKE Kapuna (Elder Wisdom) Project


NIH_SPENDING_CATS: Biotechnology;Cancer;Hematology;Immunotherapy;Infectious Diseases;Lymphatic Research;Lymphoma;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: NEW YORK

ORG_DEPT: PEDIATRICS

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: Project Narrative Many EBV+ lymphomas are able to evade the anti-EBV immune response through the restricted latency program I where only the weakly immunogenic EBNA1 protein is expressed. Here we will develop a novel approach to the treatment of EBV+ lymphomas by using hypomethylating agents to convert latency I tumors to the highly immunogenic latency III program, thereby sensitizing resistant tumors to an EBV-directed anti-tumor immune response.

PI_NAMEs: ROTH, LISA GIULINO (contact)

PROGRAM_OFFICER_NAME: READ-CONNOLE, ELIZABETH LEE

PROJECT_TERMS: African;Allogenic;anti-tumor immune response;Antigen Targeting;Antigens;Burkitt Lymphoma;Cell Death;Cell Therapy;Cells;Clinical Trials;Cytotoxic T-Lymphocytes;Decitabine;Development;Disease;EBV specific T-cells;Effector Cell;Epigenetic Process;Epitopes;Epstein-Barr Virus latency;Epstein-Barr Virus-Related Lymphoma;Epstein-Barr Virus-Related Malignant Neoplasm;Future;Goals;High Dose Chemotherapy;HIV;Human;Human Herpesvirus 4;Immune;immune activation;Immune mediated destruction;Immune response;Immunocompetent;immunogenic;Immunologics;Immunotherapy;In Vitro;in vivo;Individual;large cell Diffuse non-Hodgkin's lymphoma;latent infection;Lymphoma;Malignant Neoplasms;Mediating;Natural Killer Cells;novel strategies;novel therapeutics;Nuclear Antigens;Oncogenic;Patient-Focused Outcomes;pharmacologic;Phenotype;prevent;programs;Proteins;Recurrent disease;Resistance;resistance mechanism;Resource-limited setting;T cell response;T cell therapy;T-Lymphocyte;targeted treatment;Therapeutic;therapeutic development;treatment strategy;tumor;tumor eradication;Untranslated RNA;Viral;Viral Antigens;Viral Genome;Viral Proteins;Virus;Virus Latency;Work

PROJECT_TITLE: Targeting Latency Switch in EBV+ Lymphomas

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-D(08)F]


ORG_CITY: PHILADELPHIA

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: The aim of this proposal is to develop an ultra-high sensitive single cell-single extracellular vesicle (EV) mapping technology that can resolve both cell and EV heterogeneity. This platform will provide new molecular information on cell-cell communications via vesicle secretion and allow biomarker discovery to profile tumor immune microenvironment for immunotherapy monitoring.

PI_NAMEs: KO, JINA  (contact)

PROGRAM_OFFICER_NAME: OSSANDON, MIGUEL

PROJECT_TERMS: Achievement;Address;Antibodies;biological heterogeneity;Biological Markers;biological systems;Biology;biomarker discovery;blood-based biomarker;cancer biomarkers;cancer cell;Cancer Patient;career;Cell Communication;cell fixing;cell type;Cells;Chemistry;Clinical;clinical diagnostics;Collaborations;Communication;Data;Detection;Development;Diagnostic;digital;Dimensions;Disease;disease diagnosis;disease diagnostic;disorder subtype;Encapsulated;exosome;extracellular vesicles;Fine needle aspiration biopsy;fluorescence imaging;fluorophore;forging;General Hospitals;Generations;Glioblastoma;Goals;Harvest;Heterogeneity;Hospitals;Immune;Immunology;Immunotherapy;improved;Individual;liquid biopsy;Machine Learning;Maps;Massachusetts;Measures;medical schools;Mentors;Methods;Microfluidics;minimally invasive;Molecular;Molecular Analysis;Molecular Biology;molecular diagnostics;molecular imaging;Molecular Profiling;Monitor;Mothers;mouse model;Nanotechnology;Neoplasm Circulating Cells;neoplastic cell;neurogenetics;neurosurgery;next generation;next generation sequencing;novel;Nucleotides;Oncology;Outcome;Parents;particle;Pathologic;Patient-Focused Outcomes;Peptide Sequence Determination;Phase;Phenotype;Physics;Population;Prediction of Response to Therapy;Research;Research Personnel;Resources;responders and non-responders;response;Sampling;Signal Transduction;Stains;Systems Biology;Technology;Testing;Therapeutic;tool;translational medicine;Treatment outcome;treatment response;tumor;tumor-immune system interactions;Universities;Vesicle;Woman;Work

PROJECT_TITLE: Mapping Single Extracellular Vesicles to Parent Cells for Immunotherapy Monitoring


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Immunization;Infectious Diseases;Sexually Transmitted Infections;Urologic Diseases;Vaccine Related;Women's Health Research

ORG_CITY: INDIANAPOLIS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: PROJECT NARRATIVE Urogenital tract (UGT) infections with Chlamydia trachomatis (Ct) are increasingly prevalent, a major cause of reproductive morbidity, and annual UGT screening is recommended in <25 and high-risk women; screening for rectal CT infections is not recommended without exposure. The prospective cohort study described in this application will enroll women at high-risk for chlamydia but who have never had anal sex and, over 1-year, will (1) obtain monthly oral, vaginal, and rectal swabs to detect incident Ct infections, (2) collect quarterly blood and cervical cytobrush specimens to study systemic and cervical T-cell responses, and (3) capture weekly sexual behavior and symptoms data to screen for exposure and Ct-related symptoms. The goal of this project is to understand if rectal Ct infections in women are (Aim 1) frequent, long-lasting, asymptomatic, associated with specific rectal-tropic strains, and increase risk of UGT infection and (Aim 2) elicit significant systemic and cervical T-cell responses that may protect against incident UGT infection.

PI_NAMEs: JORDAN, STEPHEN J. (contact)

PROGRAM_OFFICER_NAME: CHUANG, ELEANORE JENNIFER

PROJECT_TERMS: Affect;Age;Age Years;Anal Sex;Animals;Antigens;Attenuated;Biological Assay;Blood;CD4 Positive T Lymphocytes;cell motility;Cells;Cervical;Chlamydia;Chlamydia muridarum;Chlamydia trachomatis;chlamydia vaccine;clinically significant;cytokine;Cytoprotection;Data;Development;diaries;Disease;Enrollment;Epidemiology;Etiology;Exhibits;Flow Cytometry;Foundations;Frequencies;Future;Gastrointestinal tract structure;Genitourinary System Infection;Genotype;Goals;high risk;High Risk Woman;Human;Immunity;immunogenic;improved;In Vitro;Incidence;Individual;Infection;infection risk;Inflammation;insight;Interferon Type II;Knowledge;Mediating;memory CD4 T lymphocyte;Mononuclear;Mucosal Immunity;mucosal vaccine;Mucous Membrane;Mus;Natural History;Nucleic Acid Amplification Tests;Oral;Oral Administration;Oral Sex;Organism;Outcome;Pathologic;Peripheral Blood Mononuclear Cell;Prevalence;prospective;Prospective, cohort study;Prostitution;Recommendation;Rectum;reproductive morbidity;Risk;routine screening;Sampling;screening;screening guidelines;Sex Behavior;Specimen;Stains;Swab;Symptoms;T cell response;T memory cell;T-Lymphocyte;Testing;Time;Tissues;urogenital tract;vaccine development;Vaccines;Vagina;Woman

PROJECT_TITLE: The influence of rectal Chlamydia trachomatis infections on immunity and incident urogenital infections in women without an indication forrectal screening


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);American Indian or Alaska Native;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Sleep Research;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

PI_NAMEs: SINCLAIR, KA'IMI ALOHILANI (contact)

PROJECT_TERMS: abeta deposition;Adherence;Age;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease related dementia;Alzheimer's disease risk;American Indian Population;American Indians;Amyloid beta-Protein;Apnea;Arizona;Attention;base;behavior test;Behavior Therapy;Behavioral;Biological Markers;Body Weight decreased;brain morphology;Breathing;Cardiovascular Diseases;Cerebrospinal Fluid;Cerebrovascular Disorders;Clinical Trials;Cognition;cognitive change;cognitive function;cohort;Cohort Studies;Communities;Complex;Data;Data Collection;Dementia;dementia risk;Development;Diabetes Mellitus;Diagnosis;Diagnostic Equipment;Disease;Disparity;effectiveness evaluation;Effectiveness of Interventions;Electronics;Eligibility Determination;Epidemiology;evidence base;Excessive Daytime Sleepiness;Executive Dysfunction;executive function;experience;Family Study;FDA approved;frontier;Functional disorder;Healthcare;Heart;High Prevalence;Home;Hour;Hypertension;Impaired cognition;improved;improvement on sleep;Individual;Intervention;Link;Long-Term Effects;low socioeconomic status;Magnetic Resonance Imaging;Measures;Mediating;member;Meta-Analysis;mild cognitive impairment;Minority;Minority Groups;motivational enhancement therapy;Native American population;natives;Neurologic;Northern Plains;novel;Obesity;Observational epidemiology;Obstruction;Obstructive Sleep Apnea;Oklahoma;older adult;Outcome;Participant;Patients;Persons;Polysomnography;Population;population based;Population Study;positive airway pressure;Positron-Emission Tomography;pragmatic randomized trial;pragmatic trial;pressure;Prevalence;Prevention program;primary outcome;Protocols documentation;Qualitative Methods;Randomized;Randomized, Controlled Trials;recruit;Reporting;Research;Research Project Grants;Reservations;Risk;Risk Factors;Site;Sleep;Sleep Apnea Syndromes;Sleep Disorders;sleep position;sleep quality;South Dakota;standard care;Symptoms;Testing;Time;treatment adherence;treatment as usual;Vascular Diseases;vascular risk factor

PROJECT_TITLE: Cognition After OSA Treatment Among Native American People


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Harm Reduction for Substance Misuse;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Pediatric;Prevention;Social Determinants of Health;Substance Misuse;Underage Drinking

ORG_CITY: LEXINGTON

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: PROJECT NARRATIVE Emerging adult sexual minority male and transgender individuals are more likely to report hazardous drinking and to have alcohol use disorders compared to those who are cisgender and heterosexual. This is concerning, as alcohol use contributes to HIV risk and HIV disproportionately affects this population. Through a randomized controlled trial, the proposed research will evaluate an enhanced motivational interviewing intervention that utilizes smartphones and mobile breathalyzers to provide real-time messaging that addresses triggers for drinking when individuals visit locations associated with risky alcohol use.

PI_NAMEs: KERSHAW, TRACE S;LAUCKNER, CAROLYN  (contact)

PROGRAM_OFFICER_NAME: FREEMAN, ROBERT

PROJECT_TERMS: Address;Adherence;Affect;aged;alcohol behavior;Alcohol consumption;alcohol monitoring;alcohol use disorder;Alcohols;arm;Behavior;behavior change;Behavioral;binge drinking;Biological;Bisexual;Cancer Survivor;Cellular Phone;cisgender;Clinic;Communities;comparison group;Connecticut;Data;drinking;Effectiveness;efficacy evaluation;emerging adult;Evaluation;Event;evidence base;experience;Gays;gender minority group;Goals;group intervention;Harm Reduction;hazardous drinking;Health;Heterosexuals;high risk;high risk drinking;high risk population;HIV;HIV risk;HIV Seronegativity;Individual;innovation;Intervention;intervention effect;Kentucky;literacy;Literature;Location;meetings;men;Methods;mobile application;Motivation;motivational enhancement therapy;older adult;Outcome;Participant;Patient Self-Report;Persons;Population;pre-exposure prophylaxis;precision medicine;prevent;primary endpoint;primary outcome;Randomized, Controlled Trials;Reading;recruit;reduced alcohol use;remote delivery;Reporting;Research;Research Personnel;Risk Behaviors;secondary endpoint;secondary outcome;Self Efficacy;sex;Sex Behavior;Sexual and Gender Minorities;sexual minority group;sexual minority male;substance use;Surveys;Technology;Testing;therapy design;Time;transgender;trend;Unsafe Sex;Visit;Vulnerable Populations;Work;young adult

PROJECT_TITLE: Evaluation of a Combined Motivational Interviewing and Ecological Momentary Intervention to Reduce Risky Alcohol Use among Sexual Minority Males and Transgender Individuals


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: LITTLE ROCK

ORG_NAME: ARKANSAS CHILDREN'S HOSPITAL RES INST

ORG_STATE: AR

PHR: Narrative In Phase I, we launched the Center for Translational Pediatric Research at Arkansas Children’s Research Institute in Little Rock, Arkansas. The mission of the center is to use proteogenomic approaches to identify epigenomic mechanisms and therapeutic targets in diseases, including cancer, impacting or translatable to the pediatric population. Our goals for the upcoming Phase II are to further enhance our institutional research infrastructure by developing our multi-disciplinary, thematic research center through strategic expansion of the critical mass of investigators, investing into research infrastructure, and implementing a plan for long-term center sustainability.

PI_NAMEs: TACKETT, ALAN  (contact)

PROGRAM_OFFICER_NAME: CUPIT, PAULINE

PROJECT_TERMS: Arkansas;Award;Bioinformatics;Biomedical Research;career;Cell Nucleus;Centers of Research Excellence;Child;Childhood;Data Analyses;data integration;Development Plans;Disease;disease mechanisms study;epigenomics;experience;Extramural Activities;faculty mentor;Foundations;Funding;Genomics;Goals;Grant;Human Resources;Individual;Institution;Institutionalization;Investments;Leadership;Malignant Neoplasms;member;Mentors;mid-career faculty;Mission;multidisciplinary;National Institute of General Medical Sciences;Pediatric Research;Phase;Pilot Projects;Population;professor;Program Development;programs;proteogenomics;Proteomics;recruit;Research;Research Infrastructure;Research Institute;Research Personnel;Research Project Grants;Research Support;Resources;Role;senior faculty;service providers;skills;Structure;success;Support System;Systems Biology;Teacher Professional Development;tenure track;therapeutic target


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Pediatric

PROJECT_TERMS: Arkansas;Biomedical Research;career development;Centers of Research Excellence;Child;Core Facility;Development Plans;Ensure;Evaluation;experience;Extramural Activities;Faculty;Foundations;Goals;Growth;Individual;Leadership;Longevity;Mentors;Mission;multidisciplinary;new growth;Pediatric Research;Phase;Pilot Projects;Productivity;programs;Research;Research Infrastructure;Research Institute;Research Personnel;Research Project Grants;Research Training;success;Teacher Professional Development;United States National Institutes of Health

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Genetics;Human Genome;Pediatric

PI_NAMEs: BYRUM, STEPHANIE D (contact)

PROJECT_TERMS: Bioinformatics;Centers of Research Excellence;Charge;Childhood;Core Facility;Data;data access;Data Analyses;Data Collection;data integration;Disease;disease mechanisms study;Doctor of Philosophy;Education;Educational workshop;epigenomics;Equipment;experience;Extramural Activities;Funding;Future;Genomics;Goals;Grant;human disease;Human Resources;Institution;member;Mission;Molecular Profiling;Multiomic Data;multiple omics;National Institute of General Medical Sciences;new therapeutic target;next generation;Nucleic acid sequencing;operation;Pediatric Research;Phase;Population;Positioning Attribute;Program Research Project Grants;proteogenomics;Proteomics;Research;Research Personnel;Research Project Grants;Research Support;Resources;service member;Services;skills;success;Technology;therapeutic target;transcriptomics

PROJECT_TITLE: Proteogenomics Core


NIH_SPENDING_CATS: Cancer;Genetics;Orphan Drug;Ovarian Cancer;Rare Diseases;Women's Health Research

ORG_CITY: Pittsburgh

ORG_NAME: MAGEE-WOMEN'S RES INST AND FOUNDATION

PHR: Cancer cell quiescence is an understudied mechanism of chemotherapy resistance and drives poor outcomes for patients with ovarian cancer. We will study the unique biology of quiescent ovarian cancer cells to identify therapeutic vulnerabilities of quiescent cells. Based on our findings we will test novel therapeutic combinations to eradicate quiescent cells to overcome chemotherapy resistance and increase disease cure rates.

PI_NAMEs: BUCKANOVICH, RONALD J (contact)

PROGRAM_OFFICER_NAME: CERO, CHERYL

PROJECT_TERMS: Adjuvant Therapy;Animals;Binding;Bioinformatics;Biologic Characteristic;Biological;Biological Factors;Biology;cancer cell;Cancer Patient;cancer type;Cell Cycle;Cell Death;Cell Proliferation;Cell Survival;Cells;Cellular biology;Cessation of life;Characteristics;Chemoresistance;chemotherapy;Combined Modality Therapy;Data;Devices;differential expression;Disease;Disease Resistance;effective therapy;Exhibits;FDA approved;Follistatin;Gene Expression Profile;genetic approach;Genetic Transcription;Goals;Human;Immunotherapy;improved;improved outcome;in vivo;inhibitor;knock-down;Knock-out;Link;Malignant neoplasm of ovary;Mediating;Messenger RNA;Microfluidics;Molecular;multicatalytic endopeptidase complex;neutralizing antibody;new therapeutic target;novel;novel strategies;novel therapeutics;Pathway interactions;Patient Care;Patient-Focused Outcomes;pharmacologic;Phenotype;prevent;Proliferating;Proteasome Inhibitor;Proteins;recruit;Recurrent disease;Refractory;Relapse;Residual Cancers;Residual state;RNA analysis;Role;Route;Sea;senescence associated secretory phenotype;senescent cell;small molecule inhibitor;System;targeted treatment;Testing;Therapeutic;therapeutic target;therapy resistant;transcriptome sequencing;Tumor Tissue;Ubiquitin;Up-Regulation;Work;Yeasts

PROJECT_TITLE: Evaluating unique aspects of quiescent ovarian cancer cell biology for therapeutic targets

STUDY_SECTION: BCO

STUDY_SECTION_NAME: Biochemical and Cellular Oncogenesis Study Section[BCO]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Genetics;Human Genome;Pediatric

PI_NAMEs: BYRD, ALICIA K. (contact)

PROJECT_TERMS: Aging;assault;ATAC-seq;Binding Sites;Biochemical;biological adaptation to stress;Cell Cycle;Cells;Centers of Research Excellence;Childhood;ChIP-seq;Chromatin;Data;Defect;Development;developmental disease;Disease;DNA;DNA lesion;DNA replication fork;Doctor of Philosophy;Epigenetic Process;epigenomics;Event;Excision;EXO1 gene;experimental study;Fragile X Syndrome;G-Quartets;Genes;Genome;genome integrity;Genome Stability;genome-wide;Genomic DNA;Genomics;Goals;HELB gene;helicase;homologous recombination;Human;Individual;insight;knock-down;Maintenance;Malignant Neoplasms;Mental Retardation;Molecular;new therapeutic target;nuclease;Pediatric Research;Phosphorylation;Population;Post-Translational Protein Processing;preservation;Process;Proliferating;protein protein interaction;Proteins;proteogenomics;Recombinants;Recovery;Regulation;repaired;Replication Initiation;replication stress;Research;Research Project Grants;Resources;Role;Site;Structure;Testing;therapeutic target

PROJECT_TITLE: Role of HELB in the Replication Stress Response


NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics;Immunotherapy;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_DEPT: BIOLOGY

PHR: Project Narrative Patients with metastatic Ewing sarcoma have a less than 10% survival rate at five years; therefore, identification of novel therapeutic targets and strategies are urgently needed to treat this type of cancer. This proposal focuses on the functional characterization of LIPI as a cell surface protein with oncogenic function and a potential immunotherapy target due to its highly specific expression pattern in Ewing sarcoma. Ultimately, the results obtained from this proposal will offer significant mechanistic understanding of the players involved in Ewing sarcoma growth and metastasis as well as making a clinical impact by identifying potential targets for treating this disease through cellular therapy.

PI_NAMEs: ASANGANI, IRFAN AHMED (contact)

PROGRAM_OFFICER_NAME: COVELL, DAVID G

PROJECT_TERMS: Affect;Antibodies;Antibody-drug conjugates;Binding;Biological Markers;Biological Process;Biology;Cancer cell line;Cancer Center;cancer type;Cancer Vaccines;Cell Line;Cell Physiology;Cell surface;Cell Surface Proteins;Cell Survival;Cell Therapy;Cells;Chickens;Child;chimeric antigen receptor T cells;Chimeric Proteins;ChIP-seq;Clinical;clinically relevant;clinically significant;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Coupled;CRISPR/Cas technology;Data;Data Set;Dependence;design;Development;Disease;Disease Progression;drug discovery;Drug Targeting;Enhancers;Ensure;epigenetic silencing;Ewings sarcoma;EWS-FLI1 fusion protein;EWSR1 gene;extracellular;FLI1 gene;Foundations;Gene Expression;Genes;genetic signature;Genetic Transcription;Genotype;Germany;Growth;Human;Hydrolase;Immune system;Immunohistochemistry;Immunotherapeutic agent;Immunotherapy;In Vitro;in vivo;Invaded;Knock-out;Laboratories;Lipase;Lipids;lysophosphatidic acid;Malignant Neoplasms;Maps;Mediating;member;Membrane;Metastatic Ewing's Sarcoma;Microsatellite Repeats;Modeling;Monoclonal Antibodies;Mus;Natural Killer Cells;Neoplasm Metastasis;new therapeutic target;Normal tissue morphology;novel;novel therapeutic intervention;novel therapeutics;Oncogenes;Oncogenic;Oncoproteins;Outcome;overexpression;Pathology;Patients;Pattern;Pennsylvania;Phenotype;Phospholipase;Physicians;Physiology;prion-like;professor;Prognostic Marker;programs;Proliferating;Proteins;Proteomics;Reagent;receptor;Recurrence;Regulation;Research;Role;Sarcoma;Scientist;Signal Pathway;Signal Transduction;Specimen;success;Surface;Surface Antigens;Survival Rate;T-Lymphocyte;The Cancer Genome Atlas;Therapeutic;Tissue Microarray;Tissues;transcription factor;Transcriptional Regulation;transcriptome;transcriptomics;Transmembrane Domain;Tumor Antigens;tumor growth;University Hospitals;Upstream Enhancer;vaccine-induced antibodies;Work;Xenograft Model;young adult;Zebrafish

PROJECT_TITLE: Discovery and characterization of exceptionally specific surface oncoprotein LIPI in Ewing Sarcoma


NIH_SPENDING_CATS: Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Cancer Genomics;Childhood Leukemia;Genetics;Hematology;Human Genome;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Umbilical Cord Blood/ Placenta;Stem Cell Research - Umbilical Cord Blood/ Placenta - Human

PI_NAMEs: ROY CHOUDHURY, SAMRAT  (contact)

PROJECT_TERMS: 3 year old;acute megakaryoblastic leukemia cell;Acute Megakaryocytic Leukemias;Acute Myelocytic Leukemia;Amino Acids;Architecture;Binding;Binding Sites;Bromodomain;CD34 gene;Cell Line;Centers of Research Excellence;Child;Childhood;Childhood Acute Megakaryoblastic Leukemia;Childhood Acute Myeloid Leukemia;Chimeric Proteins;Chromatin;chromatin remodeling;Clustered Regularly Interspaced Short Palindromic Repeats;Development;Disease;Distal;Distant;Doctor of Philosophy;Elements;Enhancers;EP300 gene;Epigenetic Process;epigenetic regulation;epigenomics;Family;GATA1 gene;Gene Expression;Genes;genetic corepressor;Genetic Enhancer Element;Genetic Transcription;genome sequencing;genome-wide;GLIS2 gene;Growth;Histone H3;Human;Impairment;In Vitro;in vivo Model;Incidence;Infant;insight;leukemia;Leukemic Cell;Link;Lysine;Malignant - descriptor;Malignant neoplasm of prostate;Mediating;Mediator;Megakaryocytes;Neoadjuvant Therapy;new therapeutic target;novel;novel therapeutic intervention;novel therapeutics;Oncogenic;Outcome;overexpression;paralogous gene;patient population;Pediatric Research;Phosphotransferases;Population;Positioning Attribute;pre-clinical;progenitor;programs;promoter;Property;Proteins;proteogenomics;recruit;Recurrence;Relapse;Reporting;Research Project Grants;Resources;response;RNA Polymerase II;Role;RUNX1 gene;small molecule;Somatic Mutation;Squamous cell carcinoma;stem cells;Survival Rate;Testing;therapeutic target;Transcription Coactivator;transcription factor;Umbilical Cord Blood;Zinc Fingers

PROJECT_TITLE: Role of MED12L- Associated Chromatin Enhancers in Pediatric Acute Megakaryoblastic Leukemia


NIH_SPENDING_CATS: Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Chronic Pain;Genetics;Human Genome;Neurodegenerative;Neurosciences;Pain Research;Pediatric;Peripheral Neuropathy;Social Determinants of Health

PI_NAMEs: STEPHENS, KIMBERLY E (contact)

PROJECT_TERMS: Action Potentials;Affect;Afferent Neurons;Axon;axon guidance;Binding;Cell model;cell type;Centers of Research Excellence;Childhood;Chromatin;Chronic;chronic pain;Collection;Complex;Cues;Development;differential expression;Disease;Distal;Doctor of Philosophy;early life stress;Environment;Epigenetic Process;epigenetic regulation;epigenomics;Family;Gene Expression;Gene Expression Regulation;Genes;Genetic Transcription;Health;Heterodimerization;In Vitro;in vivo;in vivo Model;Individual;Inflammation;inflammatory pain;Intrathecal Injections;knock-down;late life;Life;Ligation;Maps;Measures;member;Modeling;Morphology;Motor;multiple omics;nerve injury;neural;Neurites;Neuroglia;neuron development;neuronal cell body;Neurons;Nociception;Nociceptors;Nucleic Acid Regulatory Sequences;Outcome;overexpression;Pain;pain behavior;painful neuropathy;Pathway interactions;Pediatric Research;Peripheral nerve injury;Peripheral Nervous System;Persistent pain;Phenotype;Play;plexin;Population;Predisposition;Prevention;Process;proteogenomics;Proteomics;receptor;receptor binding;Refractory;regenerative;Regulation;Research Project Grants;Resources;Role;sciatic nerve;Semaphorins;Sensory;Signal Transduction;Spinal Cord;Spinal Ganglia;Stimulus;Structure;Study models;surgical pain;Testing;therapeutic target;transcription factor;transcriptome sequencing

PROJECT_TITLE: Regulation and Function of PlexinA2 Forward Signaling in Persistent Pain


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Antimicrobial Resistance;Bioengineering;Infectious Diseases;Nanotechnology;Wound Healing and Care

ORG_CITY: OMAHA

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: Project Narrative: The proposed research is relevant to public health because it will develop a novel, highly efficacious electric current-based treatment system to combat chronic wound biofilm infections. This project is relevant to NIBIB’s mission by developing transformative bioelectric technology with potential to enhance the therapeutic effect for chronic wounds.

PI_NAMEs: ZHAO, SIWEI  (contact)

PROGRAM_OFFICER_NAME: FALCONE, JESSICA

PROJECT_TERMS: Acceleration;Affect;Aftercare;American;Amputation;anti-microbial drug;Antibiotics;antimicrobial;Area;Bacteria;Bacterial Counts;bioelectricity;Cells;Characteristics;Chronic;chronic wound;Clinical;clinical application;combat;cost;Death Rate;Debridement;Development;Devices;Engineering;Family suidae;Goals;Growth;healing;Health Personnel;Healthcare;Hour;Hydrogels;improved;in vivo;Incidence;Infection;Inflammatory;innovation;Iontophoresis;Lead;Literature;Maintenance;Medical;metabolic rate;methicillin resistant Staphylococcus aureus;Methods;Microbial Biofilms;Mission;nanoparticle;National Institute of Biomedical Imaging and Bioengineering;non-healing wounds;novel;Outcome;patient mobility;Patients;Pharmaceutical Preparations;Phase;polymicrobial biofilm;prevent;Process;Public Health;Quality of life;Reporting;Research;Research Project Grants;Resistance development;resistance mechanism;resistance mutation;Resources;response;Safety;skin wound;Societies;standard of care;Sterility;System;Technology;Therapeutic Effect;Tissues;Topical application;treatment strategy;wound;wound biofilm;wound care;wound healing;Wound Infection

PROJECT_TITLE: A novel electric current-based treatment system for chronic wound biofilm infections

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Aging;Biodefense and Related Countermeasures;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: PASADENA

ORG_NAME: CALIFORNIA INSTITUTE OF TECHNOLOGY

ORG_STATE: CA

PHR: PROJECT NARRATIVE Severe and fatal COVID-19 is the result of an exaggerated inflammatory response, but what determines whether an individual has an effective antiviral immune response with mild disease, or an exaggerated response, remains unknown. The proposed research project will test whether age-related immune dysregulation and/or viral- mediated splicing disruption during the earliest phase of infection leads to a delayed or suppressed interferon response permissive to rapid viral proliferation, and a subsequently exaggerated inflammatory response. The study is uniquely able to analyze this elusive early period through the full course of infection by leveraging a repository of paired nasal swab and saliva specimens prospectively collected twice-per-day from patients who became infected with SARS-CoV-2 while enrolled in a COVID-19 household transmission study co-designed and co-led by the applicant.

PI_NAMEs: VILORIA WINNETT, ALEXANDER  (contact)

PROGRAM_OFFICER_NAME: ARNOLD, MICHELLE MARIE

PROJECT_TERMS: 2019-nCoV;Accounting;acute COVID-19;acute infection;Adult;Age;age difference;age related;Anti-viral Response;Autopsy;Biological;Biology;California;Cell Culture Techniques;Characteristics;Child;Clinical;Collaborations;computerized tools;Coronavirus;COVID-19;COVID-19 mortality;Data;Data Set;Defect;Dengue;design;Development;Diabetes Mellitus;differential expression;Disease;Disease Progression;Elderly;Enrollment;Frequencies;Functional disorder;Gene Expression;Generations;Genes;Genetic Transcription;high risk;Household;Human;Immune;Immune response;Immune System Diseases;Immunobiology;Immunology;immunoregulation;Individual;Infection;inflammatory marker;inflammatory modulation;Inflammatory Response;influenzavirus;insight;Institutional Review Boards;interest;Interferon Suppression;Interferon Type II;Interferons;Introns;Kinetics;Knowledge;Laboratories;Lead;Leukocytes;Libraries;Measurement;Measures;Mediating;Mentorship;Messenger RNA;Minor;Mission;Morbidity - disease rate;mortality;mRNA Precursor;mRNA sequencing;Mucosal Immune Responses;Mucous Membrane;nasal swab;National Institute of Allergy and Infectious Disease;Nonsense-Mediated Decay;Nonstructural Protein;novel;Nucleic Acids;Obesity;Older Population;Ontology;Organ;Pathology;Pathway interactions;Patients;permissiveness;Phase;Play;Prevention;Proliferating;Prophylactic treatment;prospective;Protein Isoforms;protein transport;Public Health;recruit;repository;Research Project Grants;respiratory;Respiratory Mucosa;response;Risk Factors;RNA Splicing;Role;Saliva;saliva sample;Sampling;SARS-CoV-2 infection;SARS-CoV-2 negative;severe COVID-19;Severities;Severity of illness;Signal Transduction;Site;skills;Specimen;Symptoms;Technology;temporal measurement;Testing;therapeutic target;Tissue Sample;Tissues;training opportunity;Transcript;transcriptome;transcriptome sequencing;transcriptomics;Translations;transmission process;Treatment Effectiveness;Viral;Viral load measurement;Viral Load result;virology;Virus;Virus Diseases;Work

PROJECT_TITLE: Longitudinal mucosal immune response to SARS-CoV-2 starting prior to infection

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F07A-A(20)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: CHAPEL HILL

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative Adult hippocampal neurogenesis plays a critical role in regulating memory and emotion, and this process is dynamically regulated by neural circuit activity. We recently identified a key subcortical region, supramammillary nucleus (SuM) in the hypothalamus, that robustly modulates hippocampal neurogenesis. Our proposal aims to decipher mechanisms underlying SuM-mediated modulation of AHN and activity-dependent contribution of SuM- enhanced ABNs to brain-wide network dynamics.

PI_NAMEs: SONG, JUAN  (contact)

PROGRAM_OFFICER_NAME: KISHORE, SANDEEP

PROJECT_TERMS: Adult;adult neurogenesis;Affective;Anatomy;Animals;Anxiety;anxiety-like behavior;awake;Behavior;Behavioral;Brain;Brain region;Calcium;Cell Nucleus;Cells;Cognitive;critical period;dentate gyrus;Development;Electrophysiology (science);Emotions;Fiber;Functional disorder;Functional Magnetic Resonance Imaging;gamma-Aminobutyric Acid;genetic manipulation;Glutamates;granule cell;Hippocampus;Hypothalamic structure;Image;improved;knock-down;Knowledge;Life;Mediating;Memory;memory retrieval;Mental disorders;Molecular;mouse model;Nature;nerve stem cell;Nervous System Disorder;neural circuit;neurogenesis;Neurons;Neurosciences;novel;novel therapeutic intervention;Pattern;Performance;Photometry;Play;Process;Production;Proliferating;Property;Proteomics;Radial;Regulation;Role;self-renewal;Site;Slice;stem cells;Stimulus;Synaptic plasticity;Testing;transmission process

PROJECT_TITLE: Regulation and functional contribution of hypothalamic modified adult hippocampal neurogenesis

STUDY_SECTION: NDPR

STUDY_SECTION_NAME: Neurodifferentiation, Plasticity, Regeneration and Rhythmicity Study Section[NDPR]


ADMINISTERING_IC: NS

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Microglia are the immune cells of the brain and are important in shaping neuronal connections during normal brain development. I have established a new system to study how microglia interact with neuronal connections known as synapses using the zebrafish vertebrate model. I will take advantage of this model to define how the immune system aids in brain development, as well as in hyperactive states like epilepsy.

PI_NAMEs: SILVA, NICHOLAS JEREMY (contact)

PROGRAM_OFFICER_NAME: LEENDERS, MIRIAM

PROJECT_TERMS: Ablation;Adult;antagonist;autism spectrum disorder;Award;Behavior;Behavioral;behavioral response;Biological Models;Biology;Brain;brain cell;Candidate Disease Gene;carboxypeptidase C;Cathepsins B;Cells;Chemicals;Clustered Regularly Interspaced Short Palindromic Repeats;Development;Disease;Epilepsy;Equilibrium;Excitatory Synapse;experimental study;Fishes;Functional disorder;Gene Deletion;Gene Expression Profile;Goals;GTP Binding;hindbrain;Histology;Hyperactivity;Image;Immune;immune activation;Immune system;Impairment;Invaded;Locomotion;Lysosomes;Mediating;Mentors;Microglia;Modeling;Molecular;Motion;mutant;neural circuit;Neurodevelopmental Disorder;neuronal circuitry;neuronal excitability;Neurons;Neurosciences;Pathway interactions;Pentylenetetrazole;Peptide Hydrolases;Phagocytes;Phagocytosis;Phase;Phenotype;Physiological;Physiology;Play;Population;Positioning Attribute;Postdoctoral Fellow;Process;programs;Proteins;Publishing;receptor;Reporter;Research;Rodent Model;Role;Series;Shapes;Slice;Synapses;System;Techniques;Testing;Therapeutic Intervention;tissue fixing;transcriptomics;Work;Zebrafish

PROJECT_TITLE: Defining the interactions between microglia and synapses in brain development and disease


NIH_SPENDING_CATS: Attention Deficit Hyperactivity Disorder (ADHD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Eye Disease and Disorders of Vision;Genetics;Mental Health;Neurofibromatosis;Neurosciences;Pediatric;Rare Diseases

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: PROJECT NARRATIVE Neurofibromatosis is an autosomal dominant disorder whose neurodevelopmental symptoms include attentional deficits, autistic features, and abnormal processing of visual information. In this research proposal, we will use a multidisciplinary approach to identify retinal and midbrain circuits that contribute to visual processing deficits, which will greatly expand our understanding of these symptoms and provide circuit-level therapeutic targets for intervention.

PI_NAMEs: ROBINSON, JOHN ELLIOTT (contact)

PROGRAM_OFFICER_NAME: LEE, CRYSTAL ANNE

PROJECT_TERMS: Acceleration;Address;Affect;Attention;Attention deficit hyperactivity disorder;Attentional deficit;autism symptoms;autosome;Axon;Behavioral;behavioral response;Brain;Brain region;Calcium;calcium indicator;Cognitive deficits;conditional knockout;Corpus striatum structure;Cues;Data;defined contribution;Dependence;Disease;Dopamine;dopaminergic neuron;Electrophysiology (science);Executive Dysfunction;executive function;Exhibits;experimental study;Fiber;FRAP1 gene;Functional disorder;gain of function;gain of function mutation;Glutamates;Guanosine Triphosphate;Heterozygote;Hydrolysis;Hyperactivity;Hypersensitivity;Image;Impulsivity;In Situ;In Vitro;in vivo;Incidence;Individual;interdisciplinary approach;Intervention;Knock-in Mouse;Knock-out;Knockout Mice;Knowledge;Language Delays;Light;MAPK1 gene;Measures;MEKs;Midbrain structure;Mitogen-Activated Protein Kinases;Modeling;motivated behavior;mouse model;Mus;mutant mouse model;Mutation;Neurobehavioral Manifestations;Neurobiology;Neurofibromatoses;Neurofibromatosis 1;Neurons;NF1 gene;Noonan Syndrome;novel;Nucleus Accumbens;Optics;optogenetics;patch clamp;Pathway interactions;Patients;Phenotype;Phosphotransferases;Photometry;PIK3CG gene;Preparation;Proteins;Proto-Oncogene Proteins c-akt;Publications;RAS inhibition;Ras/Raf;Research Proposals;response;Retina;Retinal Ganglion Cells;retinotectal;Role;sensor;Shelter facility;Signal Transduction;Speech Delay;Stimulus;superior colliculus Corpora quadrigemina;Symptoms;Testing;therapeutic target;Transgenic Mice;tumor;Up-Regulation;Ventral Tegmental Area;Visual;visual information;Visual Pathways;visual processing;visual stimulus;Visuospatial

PROJECT_TITLE: Midbrain pathways for visual hypersensitivity in neurofibromatosis type 1

STUDY_SECTION: NBVP

STUDY_SECTION_NAME: Neuroscience of Basic Visual Processes Study Section[NBVP]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: PROVIDENCE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: Narrative Patients with electrical conduction problems in the heart have no current therapeutic options for regenerating the cardiac tissue to restore conduction and reduce arrhythmia risks. This project aims to address this gap by developing a new technology that will precisely deliver a cardiomyocyte-coated thread to the heart to create a conductive cell bridge for long-lasting improvement of coordination of cardiac excitation. Successful completion of this project will increase our capabilities to regenerate conduction in multiple etiologies of conduction disorder in the heart with the long-term goal of reducing arrhythmia and improving patient outcomes.

PI_NAMEs: COULOMBE, KAREEN LK (contact)

PROGRAM_OFFICER_NAME: RUSSELL, LUISA MARIE

PROJECT_TERMS: 3-Dimensional;Action Potentials;Acute;Address;Anatomy;Arrhythmia;Atrial Fibrillation;Atrioventricular Block;Automation;Biocompatible Materials;bioelectricity;Biological;Biomanufacturing;bioprinting;Bundle-Branch Block;Calcium;calcium indicator;Cardiac;Cardiac conduction system;Cardiac Electrophysiologic Techniques;Cardiac Myocytes;cardiac resynchronization therapy;cardiac tissue engineering;Cells;Chronic;Cicatrix;Clinical;Connexin 43;Coupled;Coupling;Data;Defect;Development;Devices;Disease;Disparate;efficacy evaluation;Electric Countershock;Electronics;Electrophysiology (science);Engineering;Etiology;Failure;Fibrin;Fibrosis;Gap Junctions;Genes;Goals;Heart;Heart Diseases;high resolution imaging;Human;human induced pluripotent stem cells;Implant;Implantable Defibrillators;implantation;improved;In Vitro;in vivo;Incidence;induced pluripotent stem cell derived cardiomyocytes;Infarction;Injections;innovation;Investments;Island;Left ventricular structure;Life;Maps;millimeter;Modeling;mortality risk;Myocardial Infarction;Myocardium;Natural regeneration;Needles;new technology;novel;novel therapeutic intervention;novel therapeutics;Optics;Patient-Focused Outcomes;Patients;Phase;Phenotype;Physiological;Positioning Attribute;pressure;Pump;Rattus;repaired;resilience;restoration;Risk;Sclerosis;Signal Transduction;Social Distance;success;Surgical sutures;System;Technology;technology development;Therapeutic;Tissue Engineering;Tissues;transmission process

PROJECT_TITLE: 3D Bioprinting of a Bioelectric Cell Bridge for Re-engineering Cardiac Conduction


ORG_NAME: RESEARCH INST OF FOX CHASE CAN CTR

PHR: PROJECT NARRATIVE – HEALTH RELEVANCE Gaining insight into the molecular basis for the opposing roles that the ERK2-DBP and D domains play in MPN pathogenesis will enable us to exploit this information to develop new strategies for therapeutic intervention. Moreover, because the Ras/MAPK cascade is a critical driver in most human cancers, these findings will have critical implications for the treatment of many cancers in addition to MPN.

PI_NAMEs: SKORSKI, TOMASZ ;WIEST, DAVID L. (contact)

PROGRAM_OFFICER_NAME: SAYYED, ZULEKHA I

PROJECT_TERMS: Active Sites;Address;Adenosine Triphosphate;Attenuated;attenuation;Automobiles;Binding;cancer cell;Candidate Disease Gene;candidate identification;CBL gene;Cell Culture Techniques;Clustered Regularly Interspaced Short Palindromic Repeats;CRISPR screen;Data;Disease;Disease Progression;DNA Repair;Docking;driver mutation;efficacy evaluation;F Box Domain;Failure;genetic approach;Growth;Health;Human;Impairment;In Vitro;in vivo;in vivo Model;inhibitor;insight;Intervention;JAK2 gene;Knock-in Mouse;Knowledge;Malignant - descriptor;Malignant Neoplasms;MAP Kinase Gene;MAPK1 gene;MAPK3 gene;Mediating;Melanoma;Mental Depression;Modeling;Molecular;mutant mouse model;Mutant Strains Mice;Myeloproliferative disease;novel;novel therapeutic intervention;Oncogenes;Oncogenic;Pathogenesis;Pathway interactions;pharmacologic;Phosphotransferases;Play;Polycythemia Vera;preservation;PTPN11 gene;restraint;Role;RUNX1 gene;senescence;Series;Signal Transduction;Site;small molecule;Substrate Interaction;targeted treatment;Testing;Therapeutic;Therapeutic Intervention;therapeutically effective;time use;tumor;tumor progression;ubiquitin ligase;Validation;Work;Xenograft Model

PROJECT_TITLE: Divergent Functions of ERK Substrate Binding Domains in Pathogenesis of Myeloproliferative Neoplasms


ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: PROJECT NARRATIVE Lung cancer is the leading cause of cancer deaths worldwide and has limited treatment options. This project proposes to dissect the mechanisms underlying the oncogenic activity of eIF5B, an important translation factor that is overexpressed in lung cancer, using mouse models and human cells. Elucidating the role of this protein in lung cancer pathogenesis and characterizing the translational program driven by eIF5B will ultimately reveal new mechanisms of translational control in tumor progression and immune evasion.

PI_NAMEs: O'DONNELL, KATHRYN ANN (contact)

PROGRAM_OFFICER_NAME: GHOSH-JANJIGIAN, SHARMISTHA

PROJECT_TERMS: 5' Untranslated Regions;Acceleration;Address;Alleles;anti-PD-1/PD-L1;anti-PD-L1 antibodies;Automobile Driving;biological adaptation to stress;bronchial epithelium;Bypass;c-myc Genes;Cancer Etiology;Cancer Intervention;carcinogenesis;cell growth;Cell Physiology;Cells;Cessation of life;CRISPR screen;Data;EIF-2alpha;Ensure;Epithelial Cells;eukaryotic initiation factor-5B;experimental study;gain of function;Gene Expression;genome-wide;Germ Lines;Guanosine Triphosphate Phosphohydrolases;Heterozygote;Human;humanized mouse;Immune;immune cell infiltrate;immune checkpoint;immune checkpoint blockade;Immune Evasion;Immunocompetent;Immunocompromised Host;Immunomodulators;immunoregulation;in vivo;Initiator Codon;insight;Internal Ribosome Entry Site;Knock-out;Knockout Mice;Knowledge;KRASG12D;Laboratories;Ligands;loss of function;LoxP-flanked allele;Lung Adenocarcinoma;lung cancer cell;Lung Neoplasms;lung tumorigenesis;Malignant neoplasm of lung;Malignant Neoplasms;Mediating;Messenger RNA;Modeling;mouse model;Mus;Nature;Non-Small-Cell Lung Carcinoma;novel;Oncogenes;Oncogenic;Open Reading Frames;overexpression;Pathogenesis;Pathway interactions;Peptide Initiation Factors;Phosphorylation;Prognosis;programmed cell death ligand 1;programmed cell death protein 1;programs;Proliferating;Proteins;receptor;Repression;ribosome profiling;Ribosomes;Role;T cell response;T-Lymphocyte;Testing;Transgenic Mice;translation factor;Translations;tumor;Tumor Burden;tumor growth;Tumor Immunity;tumor progression;Tumor Promotion;tumor-immune system interactions;tumorigenesis;Untranslated Regions;Up-Regulation

PROJECT_TITLE: The role of translation initiation factor eIF5B in lung cancer pathogenesis

STUDY_SECTION: GRIC

STUDY_SECTION_NAME: Gene Regulation in Cancer Study Section[GRIC]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Physical Injury - Accidents and Adverse Effects;Rehabilitation;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_NAME: REHABILITATION INSTITUTE OF CHICAGO D/B/A SHIRLEY RYAN ABILITYLAB

PHR: PROJECT NARRATIVE Despite improved survival rates and treatment options, individuals with spinal cord injury (SCI) continue to face lifelong disability. Due to disruptions that occur in the pathways of the central nervous system, people with SCI often experience significantly reduced ability to control their movements as well as painful muscle conditions such as spasticity, reducing independence, placing increased burden on caregivers, and increasing healthcare expenses. This project is relevant to public health because it will help guide our understanding of how remaining neural connections reorganize after injury and how transmission in these motor pathways may contribute to the development of overactive reflexes, providing comprehensive knowledge about how to improve existing treatments and develop new rehabilitation strategies for SCI and other neurological conditions.

PI_NAMEs: PEREZ, MONICA A (contact)

PROGRAM_OFFICER_NAME: BAMBRICK, LINDA LOUISE

PROJECT_TERMS: Behavior;Behavioral;Caregiver Burden;Central Nervous System;Chronic;Chronic Phase;density;Development;Dimensions;Electromyography;Exercise;experience;Funding;Goals;grasp;Healthcare;Human;Hyperreflexia;improved;Individual;Injury;Knowledge;Lifelong disability;Light;Mediating;Methodology;Motor;motor behavior;Motor Neurons;Motor Pathways;Movement;Multiple Sclerosis;Muscle;Muscle Weakness;National Institute of Neurological Disorders and Stroke;Nervous System Disorder;neural;neuroimaging;Neurologic;Neuronal Plasticity;neurophysiology;neuroregulation;Pain;Pathway interactions;Persons;Physiological;Protocols documentation;Public Health;randomized placebo-controlled clinical trial;Recovery;Reflex action;rehabilitation strategy;Research;Residual state;Spasm;spasticity;Spinal;Spinal Cord;spinal cord imaging;Spinal cord injury;Stroke;success;Surface;Survival Rate;Symptoms;Synapses;System;tool;transmission process

PROJECT_TITLE: From Neural Control of Movement to Treatments for Spinal Cord Injury


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Genetics;Neurodegenerative;Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_DEPT: NEUROLOGY

PHR: The purpose of our proposed study is to elucidate how mutations in the NEK1 kinase cause Amyotrophic Lateral Sclerosis (ALS), an untreatable and devastating neurodegenerative disease. We will use a range of approaches including induced pluripotent stem cell-derived neurons, Drosophila models and postmortem ALS patient tissue to define the role of NEK1 in motor neurons and determine how its dysfunction leads to their eventual degeneration. Our work will contribute towards the identification of therapeutic targets that could be broadly relevant for ALS patients.

PI_NAMEs: KISKINIS, EVANGELOS  (contact);PANDEY, UDAI B

PROGRAM_OFFICER_NAME: GUBITZ, AMELIE

PROJECT_TERMS: age related;ALS patients;Amyotrophic Lateral Sclerosis;Antibodies;Autopsy;Behavior;Brain;C9ORF72;causal variant;Cell Cycle Regulation;Cell Line;Cell model;Cell Physiology;Cessation of life;Clinical;comorbidity;CRISPR/Cas technology;Cytoskeleton;Defect;differential expression;Disease;DNA Damage;Drosophila genus;effective therapy;Engineering;Exhibits;exome sequencing;experimental study;Family;fly;frontal lobe;Frontotemporal Dementia;frontotemporal lobar dementia amyotrophic lateral sclerosis;Functional disorder;Genes;Genetic;Genetic Heterogeneity;Genetic study;genetic variant;Homeostasis;Homologous Gene;Human;Impairment;In Vitro;in vivo;in vivo Model;induced pluripotent stem cell;Induced pluripotent stem cell derived neurons;Language;Lead;life span;Light;Link;loss of function;Loss of Heterozygosity;Mass Spectrum Analysis;Mediating;Microtubule Proteins;Microtubules;mimetics;Modeling;Motor;motor disorder;motor impairment;motor neuron function;Motor Neurons;Movement;Muscle;Mutagenesis;mutant;Mutation;Nature;Nerve Degeneration;Nervous System;Neurodegenerative Disorders;Neuronal Dysfunction;Neurons;neuropathology;neurotoxicity;NIMA;novel;Nuclear Import;Paralysed;Pathogenesis;Pathway interactions;patient derived induced pluripotent stem cells;Patients;Personality;phosphoproteomics;Phosphorylation;Phosphotransferases;Physiological;Play;Predisposition;protein expression;Proteins;Proteomics;proteostasis;receptor;Resources;response;RNA Interference;RNA metabolism;Role;Small Interfering RNA;Spinal Cord;superoxide dismutase 1;System;Temporal Lobe;Testing;therapeutic candidate;therapeutic target;Tissues;Toxic effect;Translating;Variant;Work

PROJECT_TITLE: Investigating the Contribution of ALS/FTD-Associated Mutations in the NEK1 Kinase to Disease Pathophysiology

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


NIH_SPENDING_CATS: Genetics

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Project Narrative Viruses deliver genetic information into living cells overcoming the complexity of biological membranes that surround cells and their organelles. In this proposal, we study the molecular machines and mechanisms used by bacterial viruses and herpesviruses to eject their large DNA genomes into prokaryotic and human cells. This research fills several conceptual gaps in biology, paving the way to understand the molecular mechanisms of virulence and to the application of bacterial viruses in biotechnology and medicine.

PI_NAMEs: CINGOLANI, GINO  (contact)

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TERMS: Bacteria;Bacteriophages;Biological;Biological Process;Biology;Biotechnology;cell envelope;Cell Nucleus;Cells;Complex;Creativeness;Cryoelectron Microscopy;Development;DNA;Eukaryotic Cell;Funding Mechanisms;genetic information;Genome;Gram-Negative Bacteria;Guanosine Triphosphate Phosphohydrolases;Herpesviridae;Human;Immune system;Importins;Injections;interest;Laboratories;Literature;macromolecule;Mediating;Medicine;Membrane;Membrane Proteins;Molecular;Molecular Machines;nanomachine;novel therapeutic intervention;Nuclear Import;Nuclear Pore Complex;nucleocytoplasmic transport;Organelles;pressure;Principal Investigator;Process;programs;Protein Biochemistry;Publications;receptor;Regulation;Research;Running;Science;Signal Transduction;structural biology;Structure;Viral;Viral Genome;Virulence;Virus;Visualization;Work;X-Ray Crystallography

PROJECT_TITLE: Mechanism of Viral Genome Delivery into Cells

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-V(55)R]


PHR: PROJECT NARRATIVE DNA deaminase enzymes of the AID/APOBEC3 family are critical for immune defense but can also mistarget the host genome and contribute to cancer mutagenesis. This proposal aims to leverage knowledge of mechanism and specificity of these enzymes to develop potent antagonists to counteract their pro-mutagenic activities. The outcome of this work will be the first specific and cell-active inhibitors developed using a new paradigm, whereby functionalized DNA can be used to probe or therapeutically inhibit DNA-altering processes.

PI_NAMEs: KOHLI, RAHUL MANU (contact)

PROGRAM_OFFICER_NAME: GREENBERG, WILLIAM A

PROJECT_TERMS: Address;amino group;antagonist;base;Binding;Biology;Breathing;cancer cell;cancer genome;cancer initiation;cancer type;Catalogs;Cell Line;Cell Nucleus;Cells;cellular engineering;Characteristics;Chemicals;Chimera organism;Clinical;Cyclization;Cytidine Deaminase;Cytoplasm;Cytosine;cytosine analog;Deaminase;Deamination;density;design;Dinucleoside Phosphates;Disease;Distant;DNA;DNA biosynthesis;DNA Damage;Engineering;Enzymes;Exonuclease;Family;Family member;Frequencies;Future;genetic approach;Genome;Genomics;Goals;HIV;Host Defense;Immune;improved;In Vitro;inhibitor;insight;interest;Knowledge;Ligands;Link;Malignant - descriptor;Malignant Neoplasms;Mediating;member;meter;mimicry;Molecular;Molecular Probes;multicatalytic endopeptidase complex;Mutagenesis;Mutate;Mutation;nanomolar;Nature;novel;novel strategies;nucleic acid delivery;nucleic acid inhibitor;Outcome;Pathogenesis;Pathologic;Pathologic Mutagenesis;Physiological;Play;Positioning Attribute;preference;Process;protein degradation;Proteins;Proteolysis;recruit;Resistance;response;Retroelements;Retroviridae;Risk;Role;Route;Shapes;Single-Stranded DNA;small molecule;Somatic Mutation;Specificity;stem;Structural Models;Structure;Structure-Activity Relationship;Technology;Testing;Therapeutic;therapeutic target;Time;tool;tumor;tumor initiation;tumor progression;ubiquitin-protein ligase;Ubiquitination;Uracil;Viral;Virus;whole genome;Work;Zebularine

PROJECT_TITLE: Inhibition and Catalytic Degradation of Promutagenic DNA Deaminases


ORG_CITY: CHARLESTON

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: Malignant peripheral nerve sheath tumors (MPNSTs) are the most common malignancy and leading cause of death in individuals with the common genetic disease neurofibromatosis type 1. At present, the poor outcomes seen with MPNSTs reflect our limited understanding of the key factors activating Ras signaling in these tumors coupled with an effective means of inhibiting Ras-related signaling abnormalities. This project will address this problem by establishing the therapeutic effectiveness of directly inhibiting key receptor tyrosine kinases driving hyperactive Ras signaling in MPNSTs and understanding holistically how therapeutic effectiveness changes during the course of treatment.

PI_NAMEs: CARROLL, STEVEN L. (contact)

PROJECT_TERMS: Ablation;Antibodies;Apoptosis;Automobile Driving;Biological Assay;Breast Carcinoma;Canertinib;Cause of Death;CDKN2A gene;Cell Death;Cell Line;Cell Lineage;Cell Proliferation;Characteristics;Clinical;combinatorial;Compensation;Coupled;Cytoplasm;design;Dose;drug candidate;drug relapse;Drug resistance;drug sensitivity;Drug Targeting;effective therapy;Effectiveness;effectiveness evaluation;EGFR gene;ERBB3 gene;functional loss;General Population;Genetic Diseases;Genetically Engineered Mouse;genome-wide;Genomics;Glioblastoma;Growth;Human;hyperactive Ras;IGF1 gene;Immunocompetent;In Vitro;in vivo;in vivo evaluation;Individual;inhibitor;Lung Carcinoma;Malignant Neoplasms;MAP Kinase Gene;Mediating;Melanoma;Methods;Mutation;Neoplasms;neoplastic cell;Neurofibromatosis 1;Neurofibrosarcoma;Outcome;overexpression;Pathogenesis;Pathway interactions;patient prognosis;Patients;Pharmaceutical Preparations;pharmacologic;Phenotype;PI3K/AKT;PIK3CG gene;Proliferating;Radiation;Radiation therapy;Radio;RAS inhibition;receptor;Receptor Inhibition;Receptor Protein-Tyrosine Kinases;Receptor Signaling;recruit;Recurrent tumor;Regimen;Relapse;Reproducibility;Resistance;response;Role;Sarcoma;Schwann Cells;Signal Pathway;Signal Transduction;Site;small hairpin RNA;small molecule;Suppressor Mutations;targeted agent;targeted treatment;Testing;Therapeutic;therapeutic effectiveness;therapeutic target;TP53 gene;tumor;Tumor Cell Line;tumor growth;tumor initiation;Tumor Promotion;Tumor Subtype;Tumor Suppressor Genes;Tumor Suppressor Proteins;Tumor Tissue;tumor xenograft;tumorigenesis;Xenograft procedure

PROJECT_TITLE: Therapeutic Targeting of Receptor Tyrosine Kinase Hierarchies in Schwann Cell Neoplasms

STUDY_SECTION: DT

STUDY_SECTION_NAME: Developmental Therapeutics Study Section[DT]


ORG_NAME: UNIVERSITY OF CINCINNATI

PHR: Clinical trials determine whether a neuroscience discovery can improve the health of people with neurological disorders. They are frequently hampered by regulatory or budgetary issues, difficulties with patient recruitment, and other inefficiencies. The proposed CinciNEXT clinical site will partner with the NeuroNEXT network to improve clinical trial efficiency to bring more treatments to people with neurological diseases.

PI_NAMEs: FOREMAN, BRANDON ;GLAUSER, TRACY A (contact)

PROGRAM_OFFICER_NAME: OHAYON, JOAN M

PROJECT_TERMS: Adult;Affect;age related;Agreement;Applications Grants;Award;Biological Markers;career development;Career Mobility;Caring;Childhood;Clinical;clinical biomarkers;Clinical Investigator;Clinical Research;clinical research site;Clinical Trials;Clinical Trials Network;Collaborations;Communities;community engagement;Community Outreach;Conduct Clinical Trials;Country;Data;design;Development;Education;epidemiology study;equity, diversity, and inclusion;Ethnic Origin;experience;Foundations;Funding;Future;Gender;Gene therapy trial;Generations;genetic epidemiology;Goals;Health;implementation facilitation;improved;Infrastructure;innovation;Institution;Institutional Review Boards;International;Lead;Leadership;Letters;Location;Medical center;Medicine;member;Minority Groups;Modeling;National Institute of Neurological Disorders and Stroke;Nervous System Disorder;Network Infrastructure;Neurology;Neurosciences;novel therapeutics;outreach program;Participant;patient population;Patient Recruitments;Patients;Pediatric Hospitals;Persons;phase II trial;Phase III Clinical Trials;Population;Predisposition;Preparation;Productivity;programs;Protocols documentation;Publications;Race;Randomized;recruit;Research;Research Design;Research Infrastructure;Research Personnel;research study;Role;Secure;sex;Site;skills;Specialist;Standardization;success;Testing;Training;United States National Institutes of Health;Universities;willingness

PROJECT_TITLE: Clinical Research Sites for the Network of Excellence in Neuroscience Clinical Trials (NeuroNEXT sites)


ED_INST_TYPE: OVERALL MEDICAL

NIH_SPENDING_CATS: Aging;Neurosciences

ORG_CITY: PORTLAND

ORG_DEPT: NEUROSCIENCES

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Project Narrative Glia and neurons must work together to ensure that appropriate synaptic connections are made and maintained throughout our lives. I recently completed a screen to identify novel glial regulators of synapse development, and found that the immune receptor Crq is required for elimination of inappropriate synapses that initially form during synaptic development. In this proposal, I will address which synapses undergo developmental synapse elimination and which are dependent on Crq, identify the ligand(s) that specify which synapses should be selectively eliminated, and evaluate whether these same mechanisms contribute to the synaptic loss that underlies age-related cognitive decline.

PI_NAMEs: JAY, TAYLOR REAGAN (contact)

PROGRAM_OFFICER_NAME: ULLRICH, LAUREN ELIZABETH

PROJECT_TERMS: Address;age related;age related neurodegeneration;Age-associated memory impairment;Aging;autism spectrum disorder;Biological;brain health;candidate identification;CD36 gene;Cell Culture Techniques;cell type;Data;Development;Developmental Process;differential expression;Disease;Drosophila genus;Enzyme-Linked Immunosorbent Assay;Epilepsy;Event;Exhibits;experimental study;Functional disorder;Gene Expression Profiling;Genes;Genetic Screening;Genetic Transcription;Goals;Immune system;Immunologic Receptors;Impairment;insight;knock-down;Label;Life;life span;Ligands;Maintenance;Mammals;Maps;Mediating;Mediator;Modeling;Molecular;mouse model;Nerve Degeneration;Nervous System;nervous system development;Nervous System Physiology;Neurodegenerative Disorders;Neurodevelopmental Disorder;Neuroglia;Neurons;novel;Pathologic;Pathology;Pathway interactions;Play;postsynaptic;presynaptic;Process;Proteins;Reagent;receptor;Regulation;Reporter;Research;Research Personnel;Role;Schizophrenia;screening;Signal Pathway;Specific qualifier value;Specificity;Synapses;synaptogenesis;System;Technical Expertise;tool;trafficking;Validation;Visualization;Work

PROJECT_TITLE: Investigating novel mechanisms that underlie glial-mediated synapse elimination in development and aging

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-2 Study Section [NST-2]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;HIV/AIDS;Health Services;Infectious Diseases;Primary Health Care

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: This proposal addresses the need for effective implementation of decentralized HIV care in an urban setting in Lima, Peru, where low levels of retention in care has resulted in low viral suppression levels and increased HIV incidence. Decentralization, an evidence-based practice to improve retention in care, will be guided using NIATx, an evidenced-informed implementation toolkit, combined with Project ECHO, an evidence-informed tele- education strategy to improve specialty clinical skills for non-specialists. The implementation trial uses a stepped wedge design in four large metropolitan regions in Peru with outcomes informed by the RE-AIM implementation framework.

PI_NAMEs: ALTICE, FREDERICK LEWIS (contact)

PROGRAM_OFFICER_NAME: SHARP, GERALD B

PROJECT_TERMS: Acceleration;addiction;Address;Adopted;Adoption;Affect;Age;antiretroviral therapy;barrier to care;Caring;Chronic;Clinic;Clinical;Clinical Competence;clinical practice;Clinical Skills;Clinical Trials;Collaborations;Country;Decentralization;design;Detection;Diagnosis;Education;effectiveness outcome;Epidemic;evidence base;Evidence based practice;experience;Flowcharts;Geography;Goals;Guidelines;Health;Health Benefit;health goals;Healthcare;Healthcare Systems;HIV;Hybrids;implementation framework;implementation outcomes;implementation science;implementation strategy;implementation tool;implementation trial;improved;Incidence;Income;Individual;innovation;Laboratories;Learning;low and middle-income countries;Measures;medical specialties;member;men who have sex with men;Methods;metropolitan;Modeling;mortality;Outcome;Patient Transfer;Patients;Performance;Persons;Peru;Peruvian;Politics;Population;Populations at Risk;Primary Care;primary care provider;primary health center;professional atmosphere;Public Health;Randomized;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;Reproducibility;Research Support;scale up;secondary outcome;service delivery;Services;Site;skills;social stigma;South America;South American;success;System;Time;tool;Traction;Training;urban setting;Viral;Work

PROJECT_TITLE: Innovations in Implementing Decentralized HIV Services in Peru

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Estrogen;Genetics

ORG_DEPT: OBSTETRICS & GYNECOLOGY

PHR: Estrogens play critical roles in the normal development and function of reproductive organs, mammary glands, bone, heart, vasculature, adipose, and the central nervous system, as well as common dysfunctions of the same tissues. Increased understanding the molecular mechanisms of estrogen signaling will aid in finding better ways to prevent, diagnose, and treat estrogen-related diseases, as well as suggest new ways to study the biology of estrogens in health and disease.

PI_NAMEs: KRAUS, WILLIAM LEE (contact)

PROGRAM_OFFICER_NAME: BLONDEL, OLIVIER

PROJECT_TERMS: Adipose tissue;Area;Automobile Driving;Binding;Binding Sites;Biochemical;Biological;Biological Assay;Biological Process;Biology;bone;cell type;Cells;Central Nervous System;Chromatin;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;Conserved Sequence;Development;Diagnosis;Disease;DNA Binding;Enhancers;ESR1 gene;Estrogen Receptors;Estrogens;estrophilin;experimental study;Functional disorder;Gene Expression;Gene Expression Profile;Gene Expression Regulation;Genes;Genetic Transcription;Genomics;Guide RNA;Health;Heart;Hormones;in vivo;interest;Investigation;Kinetics;Knowledge;Ligand Binding;Ligands;Link;Liver;Mammary gland;Mediating;Molecular;Mouse Strains;Mus;myometrium;novel;Outcome;Pathology;Physiology;Play;Positioning Attribute;prevent;promoter;Proteins;Proteomics;recruit;reproductive function;reproductive organ;response;RNA;RNA Binding;RNA Polymerase II;RNA-Protein Interaction;Role;scaffold;Signal Pathway;Signal Transduction;Testing;Tissues;transcription factor;Untranslated RNA;Uterus

PROJECT_TITLE: Activity of Estrogen Receptor Enhancers with Chromatin

STUDY_SECTION: MCE

STUDY_SECTION_NAME: Molecular and Cellular Endocrinology Study Section[MCE]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Orphan Drug;Prevention;Rare Diseases;Tickborne Diseases;Vaccine Related;Vector-Borne Diseases

ORG_CITY: Columbus

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: OHIO STATE UNIVERSITY

PHR: Project Narrative Importance to public health: The purpose of this project is to develop a vaccine to prevent an emerging infectious disease, human monocytic ehrlichiosis by blocking transmission of Ehrlichia chaffeensis from ticks to mammals. Ultimately, our findings are expected to reveal rational combinations of vaccine candidates and delivery methods for tick-borne pathogens that could serve as relevant scientific direction for future prophylactic discovery; however, what is learned will contribute to a broader understanding of formulation and delivery methods of vaccines for tick-borne pathogens. Relevance to NIH’s mission: our work pertains to developing fundamental and translational knowledge that will reduce the burden of human disability.

PI_NAMEs: RIKIHISA, YASUKO  (contact)

PROGRAM_OFFICER_NAME: PERDUE, SAMUEL S

PROJECT_TERMS: Adverse effects;Amblyomma;Anaplasma;Animal Model;Anti-Infective Agents;Antibiotics;Antibodies;Antibody Response;Apoptosis;Autophagocytosis;Bacteria;Binding;Blood Transfusion;Canis familiaris;cell mediated immune response;Cells;Centers for Disease Control and Prevention (U.S.);Cessation of life;Cloning;Combined Vaccines;Country;Data;Death Rate;Development;disability;DNA Sequence;DNA Vaccines;Doxycycline;Ehrlichia;Ehrlichia chaffeensis;Ehrlichiosis;Emerging Communicable Diseases;evidence base;Exposure to;expression vector;FDA approved;flu;Formulation;Future;Genetic Transcription;Geographic Locations;geographic risk;Goals;Growth;High Prevalence;high risk;Human;Immune response;Immunization;Immunize;improved;Incidence;Infection;Infectious Agent;Interferon Type II;Jet Injections;knowledge translation;large scale production;Learning;Life;Lipoproteins;Mammalian Cell;Mammals;Measures;Mediating;Membrane Proteins;Methods;Military Personnel;Mission;monocyte;Mus;Needles;neutralizing antibody;Nutrient;Outcome;pathogen;Pilum;plasmid DNA;Police;Predisposition;prevent;Prevention;Process;prophylactic;Proteins;Public Health;Publishing;Receptor Cell;Recombinants;Reporting;response;Rickettsia;Rickettsia Infections;Risk;Sentinel;Surface;Symptoms;T cell response;T-Lymphocyte;Testing;Th1 Cells;tick bite;tick transmission;tick-borne;Tick-Borne Diseases;tick-borne pathogen;Ticks;Toxic effect;transmission blocking;transmission process;Type IV Secretion System Pathway;United States National Institutes of Health;vaccine candidate;vaccine delivery;vaccine development;Vaccines;VDAC1 gene;Vector-transmitted infectious disease;Wild Animals;Work;Zoonoses

PROJECT_TITLE: Targeted Prevention of Human Ehrlichiosis


NIH_SPENDING_CATS: Clinical Research;Contraception/Reproduction;Genetics;Infertility;Rare Diseases;Stem Cell Research;Stem Cell Research - Embryonic - Human;Women's Health Research

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: NARRATIVE  Pseudohypoparathyroidism type Ib (PHP1B) is a rare imprinting disorder that can be caused by deletions/inversions/duplications involving STX16/GNAS. However, most cases are unresolved and previously not recognized abnormalities have emerged, including reduced fertility requiring IVF. By identifying novel human defects and by generating mice with mutations through iGONAD, the mechanisms allowing parent-specific GNAS methylation will be determined.

PI_NAMEs: JUEPPNER, HARALD W. (contact)

PROGRAM_OFFICER_NAME: MALOZOWSKI, SAUL N

PROJECT_TERMS: 20q13;Adult;Affect;Alleles;autosome;Birth Weight;Cells;Chromosomes;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;comparative genomic hybridization;Complex;Coupled;Defect;demethylation;Development;Disease;DNA Sequence Alteration;early-onset obesity;embryonic stem cell;Endocrine;Epigenetic Process;Exons;Female;female fertility;Fertility;Fertilization in Vitro;Fetal Growth Retardation;Gene Expression;Genes;Genetic;genetic linkage;Genome;genome sequencing;genomic locus;Growth;GTP-Binding Protein alpha Subunits, Gs;GTP-Binding Proteins;Height;Hormonal;hormone resistance;Hormones;Human;human disease;Hypocalcemia;Impairment;imprint;in vivo;Incidence;induced pluripotent stem cell;insight;Laboratories;Lead;Life;Mediating;Methylation;Molecular;Mothers;mouse model;Mus;mutant;Mutation;Neurocognitive;next generation;novel;offspring;oocyte maturation;Oocytes;Oogenesis;Parents;Paternal uniparental disomy;Patients;Pseudohypoparathyroidism;Pseudopseudohypoparathyroidism;PTH gene;Rare Diseases;receptor;Regulatory Element;Resistance;response;RNA Splicing;Sequence Deletion;short metacarpals;Syndrome;Transcript;tumor;Variant;whole genome

PROJECT_TITLE: Molecular definition of pseudohypoparathyroidism


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_DEPT: DENTISTRY

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: NARRATIVE  In this project the investigators investigate the previously unknown interactions between calvarial bone injury- induced stem cell niche signaling and the suture stem cells, which are known to play major roles in calvarial bone regeneration. The proposed studies, based on previously published and recently unpublished novel findings, will have broad impact in understanding the molecular circuitry governing craniofacial regeneration and significantly advance our understanding of how injury reshape the niche that regulates stem cell migration, expansion and differentiation. The proposed studies will identify new regulatory components and pathways in calvarial bone regeneration to shed new light on promoting calvrial bone regeneration and treating various skeletal diseases including craniofacial abnormalities.

PI_NAMEs: YANG, YINGZI  (contact)

PROGRAM_OFFICER_NAME: VERBRIDGE, SCOTT SPENCER

PROJECT_TERMS: Address;Biological Assay;bone;bone cell;Bone Development;Bone Injury;Bone Marrow;Bone Regeneration;bone repair;Brain;Calvaria;cell behavior;cell motility;Cells;Cephalic;Cicatrix;Coupled;craniofacial;Craniofacial Abnormalities;craniofacial bone;cranium;Critical Pathways;CXCR4 Receptors;Defect;Erinaceidae;Extracellular Matrix;Failure;Foundations;G Protein-Coupled Receptor Signaling;Genetic Diseases;GNAS gene;GTP-Binding Proteins;healing;Health;Heterotopic Ossification;Homeostasis;Human;Human Genetics;Impairment;in vivo;Inflammation;Injury;injury and repair;intramembranous bone formation;Joints;Label;Link;Maintenance;Mediating;Mesenchymal Differentiation;migration;Modeling;Molecular;Monoclonal Antibodies;Morbidity - disease rate;mortality;mouse model;Mus;Natural regeneration;novel;Operative Surgical Procedures;osteoblast differentiation;Osteoblasts;Osteogenesis;Pathway interactions;Patients;Play;Population;Progressive osseous heteroplasia;Publishing;receptor;reconstruction;Regulation;Research Personnel;Role;Shapes;SHH gene;Signal Induction;Signal Transduction;Site;skeletal disorder;skeletal dysplasia;skeletal regeneration;skeletal stem cell;Skeletal system;Skeleton;smoothened signaling pathway;Solid;stem cell expansion;stem cell migration;stem cell niche;stem cell proliferation;stem cells;Stromal Cell-Derived Factor 1;Surgical sutures;Testing;Therapeutic;tissue repair;Tissues;Trauma

PROJECT_TITLE: Cxcl12-Hedgehog signaling in cranial bone regeneration

STUDY_SECTION: SBDD

STUDY_SECTION_NAME: Skeletal Biology Development and Disease Study Section[SBDD]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Vector-Borne Diseases

ORG_CITY: GALVESTON

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

ORG_STATE: TX

PHR: Project narrative Mayaro virus (MAYV) is the second leading cause of alphavirus-induced febrile illness in South American countries. This project will investigate the adaptation of MAYV to be better transmitted by the urban vectors Aedes aegypti and Aedes albopictus. Our findings will fill critical missing knowledge to our understanding of MAYV transmission and will identify and experimentally validate viral genes associated with enhanced transmission.

PI_NAMEs: AGUILAR, PATRICIA VERONICA (contact)

PROGRAM_OFFICER_NAME: COSTERO-SAINT DENIS, ADRIANA

PROJECT_TERMS: Accounting;Aedes;Alpha Virus;Animal Model;Area;Attention;Brazil;Central America;Chikungunya virus;Cities;Country;Culicidae;Dengue Virus;Development;Disease Outbreaks;emerging pathogen;epidemiology study;Europe;evidence base;Evolution;Fever;forest;Frequencies;genetic analysis;Genetic study;genome sequencing;Geographic Distribution;Geographic Locations;Glycoproteins;Haiti;Health Policy;Human;Infection;Knowledge;Laboratory Study;Latin America;Maintenance;Mayaro virus;Modeling;Mus;Mutation;nonsynonymous mutation;North America;novel;pathogen;Persons;Peru;Predisposition;Primates;Public Health;Reporting;reverse genetics;Sequence Analysis;South America;South American;surveillance study;System;Testing;tool;transmission process;Travel;vector;vector competence;vector mosquito;Vectorial capacity;Viral Genes;Viral Genome;viral transmission;Virus;Virus Diseases;West Indies;whole genome

PROJECT_TITLE: Evolution of Mayaro virus and its impact on transmission by urban vectors

STUDY_SECTION: TVZ

STUDY_SECTION_NAME: Transmission of Vector-Borne and Zoonotic Diseases Study Section [TVZ]


NIH_SPENDING_CATS: Diabetes

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: The purpose of this program is to train scientists and physicians who can make scientific discoveries and apply these discoveries to the prevention and treatment of diseases in endocrinology, diabetes, obesity, metabolism, and hormone action. Training this scientific workforce is essential for improving human health.

PI_NAMEs: BASS, JOSEPH  (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TITLE: NW University Program in Endo Diabetes and Hormone Action

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Bioengineering;Emerging Infectious Diseases;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: Boulder

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF COLORADO

ORG_STATE: CO

PHR: Project Narrative: Biofilms are the largest reservoir of recalcitrant infections in hospitals. My project aims to understand the electrophysiol- ogy of biofilms across their lifecycle and leverage machine learning to discover novel drug combinations targeting these intrinsically drug-resistant pathogens.

PI_NAMEs: MEYER, CHRISTIAN T (contact)

PROGRAM_OFFICER_NAME: HUNTLEY, CLAYTON C

PROJECT_TERMS: Address;Adjuvant;Aminoglycoside resistance;Aminoglycosides;antibiotic resistant infections;antibiotic tolerance;Antibiotics;Bacteria;bactericide;Basic Science;Biological Assay;Biotechnology;Calcium;Cell Survival;Cells;Cessation of life;Chemical Structure;Clinic;Clinical;combat;combinatorial;Combined Antibiotics;commune;Complex;COVID-19;curse of dimensionality;Data;deep learning;deep learning model;density;Development;DNA biosynthesis;DNA Sequence Alteration;Drug Combinations;Drug resistance;drug resistant pathogen;Drug Synergism;Electrophysiology (science);Gene Combinations;Gentamicins;Growth;high throughput screening;Hospitals;in silico;Infection;innovation;insight;Intervention;invention;knockout gene;Life Cycle Stages;Machine Learning;machine learning model;Measurement;Measures;Mechanical Stimulation;Mechanics;Mediating;Metabolic;Methods;Microbial Biofilms;minimal inhibitory concentration;Morphology;Motility;multi-electrode arrays;new technology;non-genetic;novel drug combination;novel therapeutic intervention;Optics;Outcome;Pharmaceutical Preparations;Phase;Physiological;Physiology;Positioning Attribute;Postdoctoral Fellow;pre-clinical;Predictive Value;preempt;Probiotics;Refractory;Resistance;Role;screening;sensor;Signal Pathway;soft tissue;Speed;Suspensions;synergism;Techniques;Technology;technology development;Testing;Therapeutic;Training;training data;treatment strategy;Urinary tract infection;Work

PROJECT_TITLE: The electrophysiology of biofilm development and drug resistance

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases Advisory Committee[MID]


ADMINISTERING_IC: MD

ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Social Determinants of Health

ORG_CITY: MIAMI

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: FLORIDA INTERNATIONAL UNIVERSITY

ORG_STATE: FL

PHR: PROJECT NARRATIVE Relevance to public health: The long-term goal of the proposed Florida International Health Disparities Initiative (FIU-HDI) is to strengthen and expand capacity-building efforts of the current, ongoing FIU-HDI. These efforts include expanding FIU’s research infrastructure to train the next generation of public health, clinical, biomedical, and behavioral researchers at FIU’s Robert Stempel College of Public Health & Social Work and Herbert Wertheim College of Medicine to address health disparities in communicable and noncommunicable health conditions—and advance health equity—among underserved populations in South Florida and the Caribbean. Using community-engaged multidisciplinary approaches, these efforts will: (a) translate into advances in culturally competent interventions, leading to measurable and sustained improvements in health outcomes in these populations, and (b) enable FIU to continue contributing to diversification in the health disparities scientific workforce.

PI_NAMEs: DE LA ROSA, MARIO R;GIL, ANDRES G (contact)

PROGRAM_OFFICER_NAME: MARSHALL, VANESSA J

PROJECT_TERMS: Address;Affect;Area;Award;Behavioral;Biometry;Cardiovascular Diseases;career development;Caribbean region;Clinical;cohort;college;Communities;community collaboration;cultural competence;Data;Dedications;Development;Diagnosis;Dietetics;Discipline;disorder prevention;Doctor's Degree;doctoral student;Education;Engineering;Enrollment;Environmental Health;Epidemiology;experience;Faculty;Florida;Funding;global health;Goals;Health;health determinants;Health Disparities Research;health disparity;health equity;health inequalities;Health Promotion;Hispanic-serving Institution;HIV;HIV/AIDS;improved;Institution;interdisciplinary approach;International;Intervention;Investments;Latino;Latino Population;Malignant Neoplasms;Measurable;Medical;Medical Students;Medicine;member;Mental Health;Mentors;next generation;nutrition;Obesity;Outcome;Patient Care;Peer Review;Physicians;Population;population health;Positioning Attribute;post-doctoral training;Postdoctoral Fellow;programs;Public Health;Publications;Records;Reduce health disparities;Research;Research Infrastructure;Research Personnel;research study;Research Training;Role;Scholarship;Schools;Science;science education;social;Social Work;Students;Substance abuse problem;substance use;success;tenure track;Training;Training and Infrastructure;Training Programs;Translating;Underrepresented Students;underserved community;Underserved Population;United States;United States National Academy of Sciences;United States National Institutes of Health;Universities;university student;vulnerable community

PROJECT_TITLE: Florida International University-Health Disparities Initiative (FIU-HDI)