PI_NAMEs: GOLIN, CAROL E (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Adherence;Affect;AIDS clinical trial group;AIDS prevention;Anti-Retroviral Agents;Anti-viral Agents;Area;Behavior;Behavioral;Behavioral Sciences;Bioethics;Biology;co-infection;Code;cognitive interview;Collaborations;Communities;comorbidity;Complex;Consultations;Continuity of Patient Care;cost;COVID-19 pandemic;Criminal Justice;Data;Data Analyses;Data Collection;design;Development;Diagnosis;Directories;Discipline;Epidemic;Epidemiology;Evaluation;Event;Focus Groups;Fostering;Funding;Goals;Grant;Health;health communication;Historically Black Colleges and Universities;HIV;HIV therapy;Human;implementation science;improved;improved outcome;innovation;Institution;Interdisciplinary Study;Interest Group;International;Intervention;Investigation;Leadership;Manuscripts;meetings;member;Mentors;Mentorship;Methodology;Methods;model development;Modeling;motivational enhancement therapy;next generation;North Carolina;Outcome;outreach;pandemic disease;Peer Review;Performance;Play;Policies;Postdoctoral Fellow;pre-exposure prophylaxis;Prevention;Procedures;programs;Protocols documentation;Psychological Factors;Publications;recruit;Rennie;Research;Research Design;Research Methodology;Research Personnel;Research Proposals;Research Support;Resources;response;Role;Science;Scientist;Services;social;Social Distance;social factors;Social Sciences;social stigma;Societal Factors;Standardization;Strategic Planning;structural determinants;Structure;Students;Surveys;synergism;System;theories;therapy design;tool;tool development;Training;training opportunity;Translational Research;Translations;United States National Institutes of Health;Universities;Viral;Virus;web services;web-based tool;Work;working group;Writing

PROJECT_TITLE: UNC Center for AIDS Research Core G Social and Behavioral


ADMINISTERING_IC: AI

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Dental, Oral, and Craniofacial Disease;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Prevention;Substance Misuse

ORG_CITY: CHAPEL HILL

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PI_NAMEs: STRINGER, JEFFREY SAMUEL ALLEN (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Adherence;Affect;Africa;Africa South of the Sahara;AIDS clinical trial group;Asia;aspirate;Attention;Award;Behavioral;biobank;Biological Assay;Biomedical Research;burden of illness;career development;China;Clinical;Collaborations;Country;Creativeness;Dedications;Developing Countries;Development;Educational workshop;Ensure;Epidemic;Epidemiology;Evaluation;Exercise;Faculty;Fostering;Funding;global health;Grant;Health Services Research;Health system;HIV;HIV Seroprevalence;HIV Vaccine Trials Network;HIV/AIDS;innovation;Institution;Institutional Review Boards;interest;International;International Maternal Pediatric Adolescent AIDS Clinical Trials;Investments;Laboratories;Laboratory Personnel;Leadership;Link;Malawi;member;Mentorship;Mission;Modeling;Monitor;next generation;North Carolina;outreach;Policies;Population;Preparation;Procedures;programs;quality assurance;Regulatory Affairs;Research;Research Activity;Research Ethics;Research Personnel;Research Proposals;Research Training;Resource-limited setting;Resources;Role;Scientist;Services;Site;South Africa;Standardization;Strategic Planning;success;Surveys;Training;Training Activity;training opportunity;Translational Research;United States National Institutes of Health;Universities;Vietnam;Visit;Work;Writing;Zambia

PROJECT_TITLE: UNC Center for AIDS Research Core I International


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Clinical Research;Dental, Oral, and Craniofacial Disease;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Prevention;Sexually Transmitted Infections;Substance Misuse

PI_NAMEs: NELSON, JULIE AE (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Aging;AIDS prevention;Area;base;Basic Science;Behavioral;Biological Assay;Biological Markers;Biostatistics Core;blood-brain barrier disruption;Central Nervous System;Clinical;Clinical Research;Clinical Sciences;Clinical Trials;Clinical Trials Network;co-infection;Collaborations;Communication;Communities;comorbidity;Consultations;Data;Devices;Diagnostic;Epidemic;Epidemiology;Equipment;Evaluation;Experimental Designs;Flow Cytometry;Funding;Goals;Gonorrhea;Grant;Historically Black Colleges and Universities;HIV;HIV therapy;HIV/STD;Immunology;In Vitro;Industry;Information Dissemination;Infrastructure;innovation;Institution;Interest Group;International;Laboratories;Leadership;Measures;Medical;Mentors;Mentorship;Microbiology;minority investigator;minority student;Mission;Neurocognitive Deficit;new technology;next generation;North Carolina;novel;outreach;Paris, France;Peer Review;Performance;Policies;Prevention;Procedures;programs;Publications;repository;Research;Research Personnel;Research Priority;Resources;response;sample collection;Scientist;Services;Sexually Transmitted Diseases;Shipping;Site;Source;Specimen;Specimen Handling;Standardization;Strategic Planning;Stress;Surveys;Syphilis;Technology;Testing;Time;Training;training opportunity;transmission process;Underrepresented Minority;United States National Institutes of Health;Universities;Vaccines;virology;Work;working group;Writing

PROJECT_TITLE: UNC Center for AIDS Research Core J HIV STD Laboratory


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Burden of Illness;Cancer;Clinical Research;Dental, Oral, and Craniofacial Disease;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Prevention;Substance Misuse

PI_NAMEs: HURT, CHRISTOPHER BROWNING (contact)

PROJECT_TERMS: Acceleration;Acquired Immunodeficiency Syndrome;acute infection;AIDS education;AIDS prevention;antiretroviral therapy;Area;Awareness;Basic Science;Behavioral;Biology;career;Career Choice;Caring;Clinical;Clinical Sciences;cohort;Collaborations;comparative;Complex;Concept Review;Continuity of Patient Care;cost;COVID-19 pandemic;Data;Data Scientist;data sharing;Databases;design;Development;Diagnosis;digital;Directories;Discipline;Environment;Epidemic;epidemiologic data;Epidemiologist;Epidemiology;Extramural Activities;Faculty;Fostering;Funding;Funding Opportunities;Goals;Healthcare;Historically Black Colleges and Universities;HIV;HIV risk;HIV Seropositivity;Human Resources;implementation science;improved;Incidence;Individual;Institution;interdisciplinary approach;Investments;low health literacy;Manuscripts;Marriage;Medicine;member;Mentors;Mentorship;new technology;North Carolina;Peer Review;Perception;Persons;Pharmaceutical Preparations;Play;pre-exposure prophylaxis;Prevention;preventive intervention;Productivity;Provider;Public Health;Publications;recruit;Research;Research Personnel;Research Support;Resources;Risk;Role;Safety;scale up;Schedule;Scholarship;Science;Scientific Advances and Accomplishments;service delivery;Site;social;Social Sciences;social stigma;South Carolina;Strategic Planning;success;symposium;Technology;Testing;tool;Training and Education;Translating;transmission process;United States;United States Dept. of Health and Human Services;United States National Institutes of Health;Universities;Update;Viral Load result;virtual;Virus;webinar;Work;working group

PROJECT_TITLE: NC Collaborative HIV Epidemiology and Prevention (NC-CHEP) SWG


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Data Science;Health Services;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Prevention;Serious Mental Illness

ORG_CITY: BALTIMORE

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative Identifying effect moderators is crucial for personalized delivery of treatment and prevention interventions, but doing so is incredibly difficult using standard study designs. This work will synthesize, extend, and apply methods for identifying effect moderators when multiple studies are available, with a particular focus on the complexities in mental health research.

PI_NAMEs: STUART, ELIZABETH A. (contact)

PROGRAM_OFFICER_NAME: LUSHIN, VICTOR

PROJECT_TERMS: Adoption;Area;Attention Deficit Disorder;Bayesian learning;Bayesian Method;Behavior Disorders;behavioral health;Big Data;care outcomes;Categories;Characteristics;Childhood;clinical care;clinical decision-making;Data;Data Set;Data Sources;design;Diagnosis;Disease;Dryness;duloxetine;Effectiveness;Electronic Health Record;electronic health record system;Exhibits;experimental study;Face;Genetic;Goals;health care quality;Health system;Healthcare;Heterogeneity;improved;Individual;Injections;interest;Intervention;Learning;machine learning method;Major Depressive Disorder;Measurement;Measures;Medical;Mental Depression;Mental Health;Mental Health Services;Meta-Analysis;Methods;Modeling;multiple data sources;National Institute of Mental Health;Outcome;Palmitates;Patients;Performance;personalized intervention;Pharmaceutical Preparations;point of care;Population;prevent;Prevention;preventive intervention;Randomized;randomized trial;Randomized, Controlled Trials;Research;Research Design;Research Personnel;Resources;Risperidone;Sampling Studies;Schizophrenia;Strategic Planning;Testing;Time;Translations;treatment effect;Treatment outcome;treatment response;Universities;Work

PROJECT_TITLE: Combining data sources to identify effect moderation for personalized mental health treatment

STUDY_SECTION: SERV

STUDY_SECTION_NAME: Mental Health Services Study Section[SERV]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer

ORG_CITY: WEST LAFAYETTE

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: PROJECT NARRATIVE This proposal seeks to understand the molecular basis for how an atypical chemokine receptor (ACKR3) that is broadly involved in tumor growth and metastasis, interacts with its cellular partners to control growth pathways and the scavenging of its extracellular ligand, CXCL12, both being key for its contribution to cancer. Through the use of cutting edge biophysical techniques, hypothesis based cell-based assays, and unbiased mass spectrometry, the research team will define features and mechanisms that can be exploited to identify new treatments for cancer.

PI_NAMEs: HANDEL, TRACY M;TESMER, JOHN  (contact)

PROGRAM_OFFICER_NAME: JOHNSON, ERIC MICHAEL

PROJECT_TERMS: ADRBK1 gene;arrestin3;Arrestins;Bar Codes;Binding;Biological Assay;biophysical techniques;cancer cell;cancer therapy;Cell membrane;cell motility;Cell surface;Cell Surface Receptors;Cell Survival;Cells;chemokine;chemokine receptor;Clinical Trials;Complex;Couples;Critical Pathways;Cryoelectron Microscopy;CXCR;CXCR4 Receptors;Cytoplasmic Tail;Data;desensitization;Development;Disease;Endothelial Cells;extracellular;Extracellular Space;G protein coupled receptor kinase;G-Protein-Coupled Receptors;Goals;GRK5 gene;Growth;GTP-Binding Proteins;Hand;Heterotrimeric GTP-Binding Proteins;Immune response;Inflammatory Response;insight;leukemia;Leukocytes;Ligands;Lymphoma;Lysosomes;Malignant Neoplasms;Mass Spectrum Analysis;Mediating;migration;Molecular;Molecular Conformation;Neoplasm Metastasis;Outcome;Pathway interactions;Phenotype;Phosphorylation;Physiology;Play;Primary Neoplasm;Process;Proliferating;Protein Isoforms;Proteins;Proto-Oncogene Proteins c-akt;receptor;receptor internalization;reconstruction;recruit;Recycling;Regulation;Reporting;Research;Resolution;response;Role;scaffold;Side;Signal Transduction;Site;Solid Neoplasm;Stromal Cell-Derived Factor 1;structural biology;Structure;Therapeutic;tumor;tumor growth;uptake

PROJECT_TITLE: Regulation of the metastasis promoting chemokine receptor ACKR3 by GPCR kinases, Gβγ and arrestins

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-S(02)M]


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Congenital Heart Disease;Congenital Structural Anomalies;Genetics;Heart Disease;Lung;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Rare Diseases

ORG_CITY: Newark

ORG_DEPT: PHARMACOLOGY

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PI_NAMEs: MCCLENAGHAN, CONOR  (contact)

PROGRAM_OFFICER_NAME: CATANIA, SELEN MURATOGLU

PROJECT_TERMS: ABCC9 gene;Address;Affect;Angiotensins;Behavior;Blood Pressure;Blood Vessels;Cantu syndrome;Cardiac;Cardiac Myocytes;Cardiac Output;Cardiovascular Abnormalities;Cardiovascular Diseases;cardiovascular health;Cardiovascular Pathology;Cardiovascular system;career;Characteristics;Chronic;Complex;CRSP3 gene;Data;Disease;disease-causing mutation;Dominant-Negative Mutation;Down-Regulation;efficacy testing;Etiology;Exhibits;Fatal birth defect;Functional disorder;gain of function;Genes;Glyburide;Health;Heart Abnormalities;heart defect;Heart failure;Heart Hypertrophy;High Cardiac Output;Human;Hypoxia;in vivo evaluation;inhibitor;insight;Investigation;Ion Channel;Knock-in;Knock-out;Link;Long-Term Effects;Lung;Medical;Mentors;Modeling;Molecular;mouse model;Mus;mutant;Mutation;Neonatal;Non-Insulin-Dependent Diabetes Mellitus;novel;Pancreas;Patent Ductus Arteriosus;Pathologic;patient population;Peripheral Resistance;Pharmaceutical Preparations;pharmacologic;Phase;Phenotype;Physiology;Potassium;Preclinical Testing;Premature Infant;Protein Isoforms;Pulmonary Hypertension;Rare Diseases;Renin;Research;response;Secondary to;Signal Transduction;Smooth Muscle;Sulfonylurea Compounds;Techniques;Testing;therapeutic target;Tissues;tool;Transgenic Mice;translational study;vascular abnormality;Vascular Smooth Muscle

PROJECT_TITLE: Electrical excitability in vascular smooth muscle: from rare disease to new paradigms

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: DA

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Cost Effectiveness Research;Digestive Diseases;Drug Abuse (NIDA only);Health Services;Hepatitis;Hepatitis - C;Infectious Diseases;Liver Disease;Maternal Health;Maternal Morbidity and Mortality;Opioid Misuse and Addiction;Opioids;Pediatric;Physical Injury - Accidents and Adverse Effects;Prevention;Substance Misuse;Women's Health Research

ORG_CITY: BOSTON

ORG_NAME: BOSTON MEDICAL CENTER

ORG_STATE: MA

PHR: PROJECT NARRATIVE As opioid use disorder (OUD) and hepatitis C virus (HCV) infection prevalence continue to rise in the United States, particularly among young women, new strategies are needed to identify high-impact venues to address both epidemics together. Pregnancy is a motivating time for women to engage in care for both their own health and that of their families. This project will utilize programmatic and public health data and simulation modeling to project the clinical and cost-effectiveness of employing interventions in the perinatal care venue to reduce opioid-related mortality and HCV transmission.

PI_NAMEs: EPSTEIN, RACHEL LEE (contact)

PROGRAM_OFFICER_NAME: HIGHSMITH, KEISHER S

PROJECT_TERMS: addiction;Address;Adult;Age;Age Reporting;Award;Calibration;care costs;care delivery;care seeking;career;career development;Caring;Child;Childhood;Clinic;Clinical;clinical effect;Clinical effectiveness;Communicable Diseases;comparative cost effectiveness;cost;Cost Analysis;cost effective;cost effectiveness;Cost effectiveness research;Data;Death Rate;Decision Modeling;design;Diagnosis;Discipline of obstetrics;disease transmission;economic evaluation;efficacy evaluation;Epidemic;epidemic virus;experience;Family;Future;Goals;Health;health care service utilization;health data;health economics;health service use;Healthcare;Hepatitis C;Hepatitis C Incidence;Hepatitis C Therapy;Hepatitis C Transmission;Hepatitis C virus;HIV;Hospitalization;Human;improved;Infant;Infection;injection drug use;innovation;Inpatients;Intervention;K-Series Research Career Programs;Learning;Link;Maternal Mortality;Measures;medication for opioid use disorder;Medicine;Mentors;Methods;microcosting;Modeling;models and simulation;mortality;National Institute of Drug Abuse;Opioid;opioid epidemic;opioid misuse;opioid mortality;opioid overdose;opioid use disorder;Outcome;Overdose;overdose death;Overdose reduction;Perinatal;Perinatal Care;perinatal health;perinatal period;Persons;Pharmaceutical Preparations;Physicians;Policies;Population;Population Decreases;post pregnancy;Postpartum Period;Predisposition;Pregnancy;pregnancy related death;Pregnant Women;prenatal;Prevalence;prevent;programs;Public Health;Publishing;Quality-Adjusted Life Years;Recovery;reproductive;Research;Research Personnel;Resource Allocation;Resources;retention rate;Risk Factors;Role;Sampling;Science;Seroprevalences;Services;skills;substance use;Techniques;Testing;Time;Training;transmission process;United States;United States National Institutes of Health;virus testing;Visit;Woman;Women's mortality;Work;young woman;Youth

PROJECT_TITLE: Perinatal care as a venue to reduce opioid overdoses and hepatitis C virus incidence (PreVenT OD HCV)

STUDY_SECTION: ODHS

STUDY_SECTION_NAME: Organization and Delivery of Health Services Study Section[ODHS]


NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Drug Abuse (NIDA only);Mental Health;Neurosciences;Opioid Misuse and Addiction;Opioids;Pediatric;Post-Traumatic Stress Disorder (PTSD);Prevention;Substance Misuse;Unintentional Childhood Injury

ORG_CITY: LEXINGTON

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: PROJECT NARRATIVE Childhood trauma survivors have higher rates of treatment dropout during medication treatment for opioid use disorder (MOUD), with those who leave treatment early being at extremely high risk for recurrence of opioid use disorder (OUD). Autonomic nervous system dysregulation and inflammation may mediate risk for dropout and/or return to use during MOUD in childhood trauma survivors, but mindfulness interventions may normalize psychological and physiological changes attributable to early childhood stress. The proposed project will implement a research program to elucidate the interplay of biological and psychological risk and protective factors associated with treatment retention in individuals in MOUD to guide the development of clinical interventions, improve treatment adherence, and reduce the risks of OUD.

PI_NAMEs: MEADOWS, AMY LYNN (contact)

PROGRAM_OFFICER_NAME: LAO, GUIFANG

PROJECT_TERMS: acceptability and feasibility;addiction;Adherence;adverse childhood events;Age;Applied Skills;Area;Autonomic nervous system;Award;Biological;Biological Markers;biological systems;biomarker evaluation;biomarker identification;Buprenorphine;C-reactive protein;career;career development;Chronic;Clinic;Clinical;clinical development;clinical implementation;comorbidity;craving;Cues;Data;Data Analyses;depressive symptoms;design;Dropout;early childhood;Early treatment;Educational Intervention;Effectiveness;Emotional;Enrollment;Ensure;experience;Exposure to;Goals;Health;heart rate variability;high risk;improved;improved outcome;Individual;Inflammation;Inflammatory;inflammatory marker;Informal Social Control;innovation;insight;Institution;Interleukin-6;Intervention;K-Series Research Career Programs;Kentucky;Knowledge;Left;Link;Mediating;Mediator;Mentored Patient-Oriented Research Career Development Award;Mentorship;methadone treatment;mindfulness;mindfulness intervention;Mindfulness Training;National Institute of Drug Abuse;Nervous System Physiology;novel;online delivery;Opioid;opioid use;opioid use disorder;Outcome;Pain;Parasympathetic Nervous System;Participant;Patient Self-Report;Patients;pediatric trauma;perceived stress;Pharmaceutical Preparations;Physicians;Physiological;Population;Post-Traumatic Stress Disorders;potential biomarker;predicting response;premature;programs;protective factors;psychologic;Recording of previous events;Recovery;Recurrence;reduced substance use;relapse risk;Reporting;Research;Research Personnel;Research Support;Research Training;return to use;Risk;Risk Factors;Science;Scientist;Self-control as a personality trait;Serum;Signal Transduction;skills;skills training;Statistical Models;Stress;substance use;Substance Use Disorder;Survivors;Sympathetic Nervous System;Technology;Testing;therapy development;Training;Training Activity;Trauma;trauma exposure;treatment adherence;Treatment Factor;Treatment outcome;treatment program;treatment response;treatment risk;Universities;Work

PROJECT_TITLE: Improving Opioid Use Disorder Treatment Retention Outcomes Using Mindfulness in Childhood Trauma Survivors

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Digestive Diseases;Neurosciences

ORG_CITY: DURHAM

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: DUKE UNIVERSITY

PHR: PROJECT NARRATIVE The proposed project addresses a significant public health concern – intestinal hypersensitivity. This health burden is particularly prevalent in patients who suffer from anxiety and/or chronic stress. By dissecting a brain-vagal-to-small intestine neuroepithelial circuit, I aim to uncover a pathway to understand, and treat, intestinal hypersensitivity.

PI_NAMEs: KAELBERER, MELANIE MAYA (contact)

PROGRAM_OFFICER_NAME: CUMMINGS, DIANA M

PROJECT_TERMS: Address;Anatomy;Animals;Anxiety;Area;Black race;Brain;Brain Stem;Calcium;career;career development;Cell secretion;Cells;Cellular Assay;Chronic stress;Classification;Coculture Techniques;Communication;Complex;Data;design;detection of nutrient;Development Plans;Diagnosis;Disease;disorders of gut-brain interaction;Doctor of Medicine;Doctor of Philosophy;dorsal motor nucleus;Duodenum;Dyspepsia;Efferent Neurons;Electrophysiology (science);Endocrine;Enteroendocrine Cell;Epithelial Cells;Functional disorder;Functional Gastrointestinal Disorders;Gastroenterology;gastrointestinal;Gastrointestinal Diseases;gastrointestinal epithelium;Genes;Glutamates;Goals;gut-brain axis;Health;Hormones;Hypersensitivity;Image;In Vitro;in vivo;Individual;intestinal epithelium;Intestines;Irritable Bowel Syndrome;Knowledge;Link;Maps;Measures;Mentored Research Scientist Development Award;Mentors;millisecond;Motility;Motivation;Nature;Nerve;neural circuit;Neurobiology;Neuroepithelial;Neurons;neurotransmission;Neurotransmitter Receptor;neurotransmitter release;Neurotransmitters;Nodose Ganglion;Norepinephrine;Organoids;Pathway interactions;Patients;Persons;postsynaptic;preference;presynaptic;Public Health;Publishing;rabies viral tracing;Rabies virus;Research;Research Personnel;response;Rewards;Scaffolding Protein;Science;Sensory;Sensory Physiology;Signaling Molecule;Simplexvirus;Small Intestines;Sorting;Stimulus;sugar;Sweetening Agents;Symptoms;Synapses;targeted treatment;Testing;Time;Training;United States National Institutes of Health;Vagus nerve structure;vesicular release;Visceral;Work

PROJECT_TITLE: Efferent vagal modulation of neuropod cells in the small intestine

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK(M1)-1-C]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Eye Disease and Disorders of Vision;Regenerative Medicine;Wound Healing and Care

ORG_CITY: DALLAS

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: PROJECT NARRATIVE In this application, we investigate how corneal keratocyte behavior is regulated by extracellular matrix structure and mechanical properties, through the application of quantitative 3-D and 4-D imaging approaches in vitro, in situ, and in vivo. The studies should provide new insights into the key biochemical and biophysical signaling pathways contributing to loss and recovery of corneal transparency following injury, surgery, or disease.

PI_NAMEs: PETROLL, W MATTHEW (contact)

PROGRAM_OFFICER_NAME: MCKIE, GEORGE ANN

PROJECT_TERMS: 3-Dimensional;4D Imaging;Anisotropy;Area;Behavior;Biochemical;Biomechanics;biophysical properties;Biophysics;cell behavior;Cell Differentiation process;cell motility;Cells;Cellular biology;Clinical;clinically relevant;Collagen;Cornea;corneal epithelial wound healing;corneal scar;crosslink;Data;Development;Dimensions;Disease;Elements;Engineering;Environment;Event;Extracellular Matrix;F-Actin;Fibrin;Fibroblasts;Fibronectins;Fibrosis;Filament;Funding;Growth Factor;healing;imaging approach;In Situ;In Vitro;in vivo;Injury;insight;Integrins;Keratoconus;Knowledge;Laceration;mechanical behavior;mechanical properties;Mechanics;mechanotransduction;migration;Modeling;models and simulation;Morphogenesis;Morphology;Motility;Myofibroblast;Natural regeneration;Nature;Normal Cell;novel;Operative Surgical Procedures;Oryctolagus cuniculus;Pattern;Penetrating Keratoplasty;Photorefractive Keratectomy;Play;Procedures;Process;Publishing;Recovery;reflectance confocal microscopy;Regulation;Research;Resolution;response;restoration;Role;second harmonic generation imaging;Signal Pathway;Stromal Cells;Structure;Surgical incisions;System;Testing;Thick;three dimensional cell culture;Time;Tissue Engineering;tissue regeneration;Tissues;tool;Vimentin;wound;wound bed;wound healing

PROJECT_TITLE: Assessment of Corneal Fibroblast Biomechanical Behavior


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE The research proposed here is relevant to public health because it seeks to gain the first comprehensive understanding of the understudied kinase and potential therapeutic target TNK1. From a translational perspective, the work proposed will inform how we develop our novel TNK1 inhibitor for clinical use. The aims of this proposal are pertinent to the NIGMS goal of understanding fundamental mechanisms of cell biology.

PI_NAMEs: ANDERSEN, JOSHUA LYON (contact)

PROGRAM_OFFICER_NAME: LEWIS, MECHELLE MAYLEBEN

PROJECT_TERMS: Address;Affinity;Autoimmunity;Binding;Biological Process;Cell Culture Techniques;cell growth;Cell model;Cell Physiology;Cell Survival;Cells;Cellular biology;Clinic;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Communication;Complex;Data;Degenerative Disorder;Disease;Docking;Drug Targeting;Family;FDA approved;Foundations;G-Protein-Coupled Receptors;Goals;Health;Hematopoietic Neoplasms;Home;Human;human disease;In Vitro;inhibitor;innovation;Knock-in;Link;Malignant Neoplasms;Mediating;member;Molecular Biology;Mutation;National Institute of General Medical Sciences;Nature;novel;Occupations;Pathway interactions;patient subsets;Patients;Pharmaceutical Preparations;pharmacologic;Phosphorylation;Phosphotransferases;Physical condensation;Physiological;Polyubiquitin;prevent;protein aggregation;Protein Tyrosine Kinase;Public Health;Publishing;reconstitution;Regulation;Research;Role;SAM Domain;Sampling;sensor;Signal Pathway;Signal Transduction;Site;TBK1 gene;Testing;therapeutic target;Time;UBA Domain;Ubiquitin;Work

PROJECT_TITLE: The Regulation and Function of the Ubiquitin-Sensing Kinase TNK1

STUDY_SECTION: CSRS

STUDY_SECTION_NAME: Cellular Signaling and Regulatory Systems Study Section[CSRS]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Hematology;Kidney Disease

ORG_CITY: CLEVELAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

ORG_STATE: OH

PI_NAMEs: GARVIN, JEFFREY L. (contact)

PROGRAM_OFFICER_NAME: MARIC-BILKAN, CHRISTINE

PROJECT_TERMS: Achievement;Area;Basic Science;Benchmarking;Benign;Biometry;career;career development;Clinical;Clinical Sciences;Committee Members;Competence;Consumption;design;Development;Development Plans;Educational process of instructing;Equilibrium;Evaluation;expectation;experience;faculty mentor;Feedback;flexibility;Functional disorder;Funding;Goals;Grant;Health;Hematology;improved;Individual;innovation;Instruction;Investigation;Kidney;Laboratories;Leadership;matriculation;meetings;Mentors;Methodology;Mission;Monitor;National Institute of Diabetes and Digestive and Kidney Diseases;Nephrology;next generation;Policies;Positioning Attribute;Postdoctoral Fellow;pre-doctoral;preservation;Professional Organizations;Professional Role;Program Evaluation;programs;recruit;Research;Research Personnel;Research Project Grants;Research Support;Research Training;responsible research conduct;Role;Science;Series;skills;sound;Structure;success;Teacher Professional Development;Time;TNFSF15 gene;tool;Training;Training Programs;Underrepresented Populations;United States National Institutes of Health;Urology;Vision;Work;Writing

PROJECT_TITLE: KUH-TN Training Core


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Contraception/Reproduction;Depression;Estrogen;Mental Health;Mental Illness;Serious Mental Illness;Suicide;Women's Health Research

ORG_CITY: PROVIDENCE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: NARRATIVE The current project will evaluate a novel theory of how changes in ovarian hormones differentially exacerbate psychopathology across the menstrual cycle. We will examine links from hormones to behavioral mechanisms to symptoms in a sample of female individuals with borderline personality disorder symptoms. Results will have implications for development of pharmacologic and psychosocial treatments to reduce the impact of hormones on a broad range of costly symptoms.

PI_NAMEs: PETERS, JESSICA RACHAEL (contact)

PROGRAM_OFFICER_NAME: TALKOVSKY, ALEXANDER MAXWELL

PROJECT_TERMS: Age;Aggressive behavior;Alcohol consumption;Anger;associated symptom;Automobile Driving;Behavior;Behavioral;Behavioral Mechanisms;Behavioral Symptoms;binge drinking;biobehavior;Biological;Biological Assay;Borderline Personality Disorder;Characteristics;Clinical Services;clinically significant;cognitive capacity;cognitive function;cost;Data;Depressive disorder;depressive symptoms;Development;Diagnosis;Diagnostic;diaries;Down-Regulation;Eating Disorders;Emotional;Emotions;Estrogens;Exclusion Criteria;experience;falls;Family;Feeling hopeless;Feeling suicidal;Female;Health Personnel;Health system;Heterogeneity;Hormonal;Hormonal Change;hormone sensitivity;Hormone use;Hormones;Impaired cognition;improved;Impulsivity;Individual;Individual Differences;interpersonal conflict;Intervention;Laboratories;Link;Longitudinal Studies;Luteal Phase;Measures;Mediating;Mediation;Menstrual cycle;Menstruation;Mental Depression;Mental disorders;Mental Health;Modeling;motivated behavior;Nature;neural;novel;Ovarian hormone;Ovulation;Participant;Patient Self-Report;Pattern;Persons;Pharmaceutical Preparations;pharmacologic;Phase;Progesterone;proliferative phase Menstrual cycle;psychologic;Psychopathology;psychosocial;Questionnaires;recruit;reproductive hormone;Research;Research Domain Criteria;Rewards;Risk Taking;rumination;Sampling;social;social media;Source;Steroids;Stress;Substance abuse problem;substance misuse;substance use;suicidal;Suicide;Symptoms;Test Result;Testing;theories;Theory of Change;trait;Urine;Visit;Withdrawal;Woman

PROJECT_TITLE: Distinct Steroid Mechanisms in Menstrual Cycle Exacerbation of Psychopathology

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurosciences;Social Determinants of Health

ORG_CITY: PHILADELPHIA

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PI_NAMEs: CASTRELLON, JAIME JORGE FERNANDO (contact)

PROGRAM_OFFICER_NAME: VAN'T VEER, ASHLEE VICTORIA

PROJECT_TERMS: Affect;Affective;Age;Alternative Therapies;Animals;Anterior;autism spectrum disorder;Behavior;Behavioral;Belief;Brain;Brain region;career;Characteristics;Child;Clinical;Cognitive;cognitive process;Communities;competitive environment;Complex;Computer Models;Corpus striatum structure;cost;Cost Sharing;Cues;Data;Decision Making;design;Diagnostic;Dimensions;Disease;Dopamine;Economics;Elements;emotion regulation;Emotions;Employee;Environment;Evaluation;Exhibits;experience;experimental study;flexibility;Functional Magnetic Resonance Imaging;Future;Gender;Goals;Health Personnel;Hospitals;Human;Individual;insight;Insula of Reil;Intervention;Learning;learning ability;Life;Link;Medical;Mental Processes;mentalization;Monitor;MRI Scans;Multivariate Analysis;neural;neural circuit;neural patterning;neuroimaging;neuromechanism;Occupations;Outcome;Parents;Participant;Patients;Pattern;Perception;Performance at work;Persons;Positioning Attribute;preference;Prefrontal Cortex;Process;psychologic;Psychopathology;Research;Rewards;Role;Sampling;Schizophrenia;Shapes;social;Social Behavior;social deficits;social disparities;Social Dominance;Social Environment;Social Functioning;Social Hierarchy;social influence;Social Interaction;social learning;Social Power;Social Processes;Social status;Societies;Socioeconomic Status;Source;System;teacher;Testing;Time;trait;Trust;Update;Work;Workplace

PROJECT_TITLE: Neural mechanisms of stable and transient hierarchy on social decision making


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse;Substance Misuse Prevention

ORG_CITY: LOS ANGELES

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: NARRATIVE This study is relevant to public health in that it will test whether an intervention to eliminate structural racism and discrimination via academic tracking reduces substance use and other risky health behaviors during adolescence and the transition to adulthood. Adolescent substance use may have long-term impacts on brain development, in addition to associations with other risky health behaviors and future substance abuse disorders during the transition to adulthood. Academic tracking may directly affect adolescent and young adult social networks, substance use, other health behaviors, and long-term health and life trajectories.

PI_NAMEs: DUDOVITZ, REBECCA N (contact)

PROGRAM_OFFICER_NAME: GOLDSTEIN, AMY B

PROJECT_TERMS: Academic support;Address;Adolescent;Adolescent and Young Adult;adolescent substance use;Adult;Affect;Alcohols;Behavior;Black race;boys;Brain;California;Cannabis;Chronic Disease;college;Color;Communities;comparison control;Control Groups;Data;demographics;Development;Discrimination;Disease;Disparity population;Drug abuse;drug abuse prevention;Education;education resources;Educational Status;Enrollment;Ensure;ethnic disparity;ethnic diversity;experience;Exposure to;Future;Group Practice;Grouping;Health;Health behavior;Health Policy;high school;higher education;illicit drug use;improved;Individual;Instruction;Intervention;Knowledge;Latinx;Life;Link;Location;Longitudinal Studies;Measures;Mission;Morbidity - disease rate;mortality;National Institute of Drug Abuse;Outcome;Participant;peer;perceived stress;Performance;Pilot Projects;poor health outcome;primary outcome;programs;psychosocial wellbeing;Public Health;racial disparity;racial diversity;Randomized;randomized trial;reduced substance use;Research;Schools;Self Efficacy;social health determinants;Social Network;Social support;Structural Racism;Students;Substance abuse problem;substance use;success;Surveys;Testing;Tobacco;Training;transition to adulthood;twelfth grade;Underrepresented Populations;vaping;Violence;Work

PROJECT_TITLE: Structural racism in schools: Evaluating the impact of academic tracking and de-tracking on substance use and health during adolescence and the transition to adulthood


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Anorexia;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Eating Disorders;Mental Health;Mental Illness;Nutrition;Patient Safety;Pediatric;Serious Mental Illness

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Atypical anorexia nervosa is a new diagnosis describing patients with malnutrition and significant weight loss yet “normal” weight. These patients responded poorly to the superior refeeding treatment in the parent trial. The proposed trial will examine the safety and efficacy of a new treatment that has the potential to improve treatment outcomes for this diverse and growing patient population.

PI_NAMEs: GARBER, ANDREA K (contact)

PROGRAM_OFFICER_NAME: WINER, KAREN

PROJECT_TERMS: Admission activity;Adolescence;Adolescent and Young Adult;Adopted;Age;Anorexia Nervosa;Appearance;Attitude;Behavior;Blood Pressure;Body Image;Body mass index;Body Weight decreased;boys;Caloric Restriction;Calories;Charge;Childhood;clinical practice;clinical remission;cognitive recovery;cohort;Communities;comparative efficacy;Consensus;Consent;cost;cost effectiveness;Data;design;Diagnosis;Disease;Disparity;Dose;Eating Disorders;Electrolytes;Energy Metabolism;Enrollment;Estradiol;feeding;Follicle Stimulating Hormone;follow-up;girls;Goals;Heart Rate;Hormonal;hospital readmission;Hospitalization;Hospitals;Hydrocortisone;Hypokalemia;Hypophosphatemia;improved;improved outcome;Incidence;individualized medicine;Inpatients;Length of Stay;Leptin;Luteinizing Hormone;Malignant Childhood Neoplasm;Malnutrition;Medical;Menstruation;Mental disorders;Metabolic;mortality;Newly Diagnosed;novel strategies;Nutritional;Outcome;Overweight;Parents;Participant;patient population;Patient Readmission;Patients;Pharmaceutical Preparations;Population;Prognosis;programs;psychologic;psychological symptom;Questionnaires;Randomized;Randomized, Controlled Trials;rapid weight gain;Recovery;Rehabilitation therapy;Research;Rest;Risk;risk minimization;Safety;Savings;Severity of illness;social culture;Specific qualifier value;standard of care;Starvation;Syndrome;Temperature;Testing;Testosterone;Treatment outcome;Weight;Weight Gain;Work;young adult

PROJECT_TITLE: Multi-center Randomized Controlled Trial of Refeeding an Anorexia Nervosa

STUDY_SECTION: NRCS

STUDY_SECTION_NAME: Nursing and Related Clinical Sciences Study Section[NRCS]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Contraception/Reproduction;Genetics;Human Genome;Infertility;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

ORG_DEPT: VETERINARY SCIENCES

PHR: Project Narrative Adult spermatogonial stem cells (SSCs) are the foundation of life-long sperm production in males. Our studies focus on understanding how SSCs are maintained through adulthood and completion of this project will provide important insights into the regulation of male fertility, the etiology of infertility, and reproductive medicine.

PI_NAMEs: WANG, PEIJING JEREMY (contact)

PROGRAM_OFFICER_NAME: KENT, TRAVIS JOHN

PROJECT_TERMS: Adult;Animals;ATAC-seq;Biological;Biological Assay;cancer cell;Cells;Chemicals;ChIP-seq;Chromatin;Chromatin Remodeling Factor;cytokine;Data;Dissection;Donor person;Epigenetic Process;Equilibrium;Etiology;Failure;Foundations;Gene Cluster;Gene Expression;Gene Transfer Techniques;Generations;Genes;Genetic;Genetic study;Genetic Transcription;Genome;Genomics;Germ Cells;germline stem cells;glial cell-line derived neurotrophic factor;Histone H3;Homeobox Genes;Immunoprecipitation;In Vitro;Infertility;Informal Social Control;inhibitor;innovation;insight;Intrinsic factor;knock-down;Life;male;male fertility;Male Infertility;Mass Spectrum Analysis;Mediating;Methylation;Methyltransferase;Molecular;multiple omics;Mus;mutant;novel;Nucleosomes;Play;Production;progenitor;programs;Proteins;Proteomics;recruit;Regulation;Reproductive Medicine;Research;Resolution;RNA Polymerase II;Role;self-renewal;single cell ATAC-seq;single-cell RNA sequencing;Small Interfering RNA;sperm cell;Spermatogenesis;Spermatogonia;stem cell biology;stem cell division;stem cell niche;stem cell population;stem cell self renewal;Stem cell transplant;stem cells;Testis;transcription factor;Transcriptional Activation;transcriptome sequencing;translational applications;Transplantation;ZNF145 gene

PROJECT_TITLE: Epigenetic control of spermatogonial stem cell self-renewal

STUDY_SECTION: CMIR

STUDY_SECTION_NAME: Cellular, Molecular and Integrative Reproduction Study Section[CMIR]


ORG_CITY: Columbus

ORG_DEPT: GENETICS

ORG_NAME: OHIO STATE UNIVERSITY

PHR: PROJECT NARRATIVE Loss of the RB1 tumor suppressor results in the transcription of cell death genes, but not a corresponding increase in cell death proteins. We found that the translation of these cell death mRNAs is silenced by the Pumilio complex of RNA binding protein(s). We propose to utilize a unique Auxin-inducible degron-mediated protein degradation system to dissect the detailed mechanism(s) associated with Pumilio complex regulation of pRB-regulated cell death transcripts in model human cells, Small Cell Lung Cancer (SCLC) cells and a well- defined murine SCLC model.

PI_NAMEs: MILES, WAYNE  (contact)

PROGRAM_OFFICER_NAME: LUO, RUIBAI

PROJECT_TERMS: Affect;Alleles;Apoptosis;Apoptotic;Auxins;Binding;Binding Proteins;BRAT gene;cancer cell;Cancer Cell Growth;Cancer Model;cancer therapy;Cell Cycle;Cell Death;cell growth;cell growth regulation;Cell Proliferation;Cells;Complex;Coupling;cytotoxic;Data;Development;E2F transcription factors;Gene Expression Regulation;gene repression;Genes;Genetic Transcription;Genetically Engineered Mouse;Genomics;Homologous Protein;Human;human disease;Human Engineering;Human Genome;human model;Individual;inducible Cre;Kinetics;Link;LoxP-flanked allele;lung cancer cell;Malignant Neoplasms;Mediating;member;Messenger RNA;Metabolic;Methods;MicroRNAs;Modeling;Mus;mutant;Necrosis;Neoplasm Metastasis;Neoplasms;novel;Pathologic;Pathway interactions;Patients;Pattern;Play;posttranscriptional;prevent;Process;Production;Proliferating;Protein Biosynthesis;protein complex;Protein Deficiency;protein degradation;Protein Family;protein function;Proteins;RB1 gene;Regulation;response;Ribosomes;RNA;RNA analysis;RNA Stability;RNA-Binding Proteins;Role;small cell lung carcinoma;Survival Rate;System;Testing;therapy design;Transcript;Transcription Coactivator;Translation Initiation;Translational Regulation;Translations;tumor;Tumor Promotion;Tumor Suppressor Proteins;tumorigenesis;uncontrolled cell growth;Work;Zinc Fingers

PROJECT_TITLE: The Translational Regulation of Pro-apoptotic Genes

STUDY_SECTION: CAMP

STUDY_SECTION_NAME: Cancer Molecular Pathobiology Study Section[CAMP]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Genetics;Pediatric;Precision Medicine;Rare Diseases

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE Juvenile dermatomyositis (JDM) is a potentially life-threatening pediatric autoimmune disease that often first presents with cutaneous inflammation and variably progresses to severe organ involvement, disease chronicity and damage. Development of an improved understanding of molecular and cellular mechanisms of treatment response in JDM holds the potential to inform precision medicine approaches to diagnosis, monitoring and treatment for children with JDM. This project will characterize gene expression signatures of skin and inflammatory cells in JDM to identify treatment response biomarkers and to advance understanding of tissue- specific disease mechanisms, while providing training to the candidate in dermatologic immunology and systems biology analytic approaches.

PI_NAMEs: TURNIER, JESSICA LEIGH (contact)

PROGRAM_OFFICER_NAME: WANG, YAN Z

PROJECT_TERMS: Adhesives;Affect;Autoimmune Diseases;Automobile Driving;biobank;Bioinformatics;Biological Markers;Biology;biomarker development;Blood;Blood specimen;Calcinosis;career;career development;Caring;Cells;Cellular biology;Child;Childhood;Chronic;Chronic Disease;Clinical;cohort;Cutaneous;Data;Dermal;Dermatologic;Development;Diagnosis;Disease;Enrollment;Exanthema;Flare;Functional disorder;Funding;Gene Expression;Gene Expression Profile;Genes;Genetic Transcription;Goals;Heterogeneity;Idiopathic Inflammatory Myopathies;Immune;Immune system;Immunology;improved;individual patient;Inflammation;Inflammation Mediators;Inflammatory;insight;intercellular communication;Investigation;Juvenile Dermatomyositis;keratinocyte;Knowledge;Life;Longitudinal cohort;Lung Diseases;Macrophage;Mediator;Mentors;Methodology;Methods;Michigan;Modeling;Molecular;Molecular Analysis;Molecular Disease;Molecular Target;Monitor;Muscle;Muscle Weakness;Myelogenous;Myeloid Cells;Myopathy;Myositis;non-invasive monitor;novel;novel marker;oral communication;Organ;Outcome;Pathologic;Pathology;Pathway interactions;patient oriented;Patients;Pattern;peripheral blood;Peripheral Blood Mononuclear Cell;Phenotype;Physicians;Population;precision medicine;professor;Prognostic Marker;Prospective cohort;Proteins;Refractory;Research;Research Design;Research Personnel;Residual state;Resolution;response;response biomarker;rheumatologist;RNA;Role;Sampling;Scientist;Signal Transduction;single-cell RNA sequencing;skills;Skin;skin biopsy;skin disorder;support tools;Symptoms;Systemic disease;systemic inflammatory response;Systems Biology;targeted treatment;Techniques;Therapeutic immunosuppression;therapeutic target;Tissues;Training;transcriptome;transcriptome sequencing;transcriptomics;Translational Research;treatment response;Treatment Side Effects;Universities;Writing

PROJECT_TITLE: Harnessing cutaneous transcriptional and myeloid cell signatures to understand treatment response in juvenile dermatomyositis

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Data Science;Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Neurosciences;Pediatric

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE Executive function is an important domain of cognition that develops rapidly during childhood, and executive dysfunction is associated with risk taking behaviors, a broad range of negative outcomes, and psychiatric illness. A greater understanding of individual variation in brain networks that support executive function may be critical for the development of personalized interventions in diverse conditions. These novel clinical interventions would benefit the public health by reducing disability and limiting the costs to society at large.

PI_NAMEs: FAIR, DAMIEN A (contact);SATTERTHWAITE, THEODORE

PROGRAM_OFFICER_NAME: THOMAS, LAURA ANDERSON

PROJECT_TERMS: Adolescence;Adolescent;Adult;Age;Anatomy;Atlases;Attention;Behavior;Brain;Brain region;Child;Childhood;Clinical;Clinical Data;Code;Cognition;cognitive development;cognitive performance;Communities;connectome;convolutional neural network;cost;Data;data acquisition;data resource;Data Set;deep learning model;Development;Dimensions;disability;Ensure;Executive Dysfunction;executive function;Failure;follow-up;Functional Imaging;Functional Magnetic Resonance Imaging;Genomics;Graph;high resolution imaging;Human;human old age (65+);human subject;Image;improved;Individual;Individual Differences;individual variation;innovation;inter-individual variation;Intervention;Learning;longitudinal dataset;Machine Learning;Maps;Measures;Mental disorders;Methods;Modeling;multi-scale imaging data;Neuroanatomy;neuroimaging;Neurons;neuroregulation;Neurosciences;novel;open data;Outcome;Pattern;personalized intervention;Process;programs;Psychopathology;Public Health;Publishing;quality assurance;Reporting;Reproducibility;Research;Resolution;Resources;Risk Taking;Sampling;Scanning;Site;Societies;Spatial Distribution;Standardization;support network;Symptoms;System;targeted treatment;Techniques;Testing;tool;Training;translational study;Travel;Validation;Variant;Work;Youth

PROJECT_TITLE: Precision mapping of individualized executive networks in youth

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Mental Health;Neurodegenerative;Neurosciences;Parkinson's Disease

ORG_CITY: ORANGEBURG

ORG_NAME: NATHAN S. KLINE INSTITUTE FOR PSYCH RES

ORG_STATE: NY

PHR: NARRATIVE We aim to establish novel chemogenetic neuromodulation strategies in nonhuman primates (NHPs) that build upon the strengths of deep brain stimulation (DBS) but resolve many DBS limitations, and to translate these to clinical therapies in humans. Our research plan has a tool development (UG3) phase followed by a pre-clinical trial (UH3) phase. Success in this work will lead to significant improvement in the treatment of Parkinson’s Disease and other neurological/psychiatric disorders. It will also provide new tools for brain circuit dissection that will greatly benefit a more specific understanding of the way particular brain circuits contribute to behavior and cognition.

PI_NAMEs: PRZEDBORSKI, SERGE E;SCHROEDER, CHARLES E (contact)

PROGRAM_OFFICER_NAME: KIM, DOUGLAS SUN-IL

PROJECT_TERMS: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine;Agonist;Anatomy;Area;Autopsy;Behavior;Behavior assessment;Behavioral;behavioral response;Benserazide;Bilateral;Biological Markers;Blinded;Brain;brain pathway;Chorea;Chronic;Clinical;Cognition;Combined Modality Therapy;Corpus striatum structure;Deep Brain Stimulation;density;Dependovirus;designer receptors exclusively activated by designer drugs;Disease;Dissection;Dopamine;dosage;Dose;drug distribution;Effectiveness;Enterobacteria phage P1 Cre recombinase;Euthanasia;Evaluation;experimental study;Female;fluorodeoxyglucose positron emission tomography;Focused Ultrasound;follow-up;Future;gene therapy;Genetic;Globus Pallidus;Goals;Histologic;Histology;Human;improved;in vivo;indexing;Individual;Infection;Inflammatory;Injections;Levodopa;Ligands;male;Mechanics;Mental disorders;Methods;Monitor;Monkeys;Motor;motor symptom;MPTP non-human primate;Mus;Neurologic;Neurons;neuropathology;neuroregulation;Neurotoxins;nonhuman primate;novel;Operative Surgical Procedures;Oral;Oral Administration;Parkinson Disease;Parkinsonian Disorders;parkinsonian non-human primate;Pathway interactions;Phase;Positron-Emission Tomography;preclinical trial;receptor;receptor expression;Regimen;Reproducibility;Research;Research Personnel;Safety;Side;side effect;Sonication;standard care;Structure of subthalamic nucleus;success;surgical risk;Testing;Tissues;tool;tool development;Translating;translation to humans;Translations;Universities;Validation;vector;Viral;Viral Vector;Work

PROJECT_TITLE: Circuit-specific, chemogenetic neuromodulation in nonhuman primates.


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Colorectal Cancer;Digestive Diseases;Nutrition;Obesity;Physical Activity;Physical Rehabilitation;Prevention;Rehabilitation

ORG_CITY: BATON ROUGE

ORG_NAME: LSU PENNINGTON BIOMEDICAL RESEARCH CTR

ORG_STATE: LA

PHR: PROJECT NARRATIVE Myosteatosis occurs when fat infiltrates skeletal muscle tissue. Myosteatosis is common and predicts cancer recurrence, cardiovascular disease, and death in colon cancer survivors. This study will determine if aerobic exercise improves prognosis in colon cancer survivors by reducing myosteatosis.

PI_NAMEs: BROWN, JUSTIN C (contact)

PROGRAM_OFFICER_NAME: BERRIGAN, DAVID

PROJECT_TERMS: adipocyte biology;Adipose tissue;Aerobic Exercise;Ankle;attentional control;behavior change;Biological;Body Weight;Cancer Prognosis;cancer recurrence;cancer risk;Cancer Survivor;Carbon Dioxide;Cardiovascular Diseases;Certification;Cessation of life;Clinical;Colon Carcinoma;Control Groups;Counseling;Data;Diagnosis;digital;disability;Energy Metabolism;Exercise;exercise adherence;exercise physiologist;exercise prescription;exercise training;Fatty acid glycerol esters;fatty acid metabolism;fatty acid oxidation;Fatty Acids;Funding;Glycerol;Health;Health Promotion;Heart Rate;heart rate monitor;Home;Human body;Impairment;improved;Infiltration;Inflammation;insight;Insulin Resistance;Intervention;Isometric Exercise;Isotonic Exercise;Isotope Labeling;Isotopes;Knee;Liquid substance;Liver;Longevity;Louisiana;Lower Extremity;Magnetic Resonance Imaging;Malignant Neoplasms;Measures;Metabolic;metabolic phenotype;Metabolism;Modeling;Morbidity - disease rate;mortality;Muscle;Muscle function;muscle physiology;muscle strength;Nonesterified Fatty Acids;novel;Obesity;older adult;Oncology;oxidation;Palmitates;Pathway interactions;patient oriented;Physical activity;Physical Function;physical inactivity;Population-Based Registry;Probability;Prognosis;prognosis biomarker;Quality of life;Randomized;Randomized, Controlled Trials;recruit;response;Risk;secondary analysis;SEER Program;Series;Skeletal Muscle;socioeconomic diversity;Stretching;Structure;Study Subject;synergism;Techniques;Telephone;Testing;Tissues;treadmill;Triglycerides;tumor registry;uptake;video chat;Visceral fat;Weight maintenance regimen

PROJECT_TITLE: Effects of Aerobic Exercise on Skeletal Muscle Remodeling in Colon Cancer

STUDY_SECTION: BMHO

STUDY_SECTION_NAME: Biobehavioral Medicine and Health Outcomes Study Section[BMHO]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cocaine;Drug Abuse (NIDA only);Genetics;Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: CHICAGO

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative  The pathogenic mechanisms of cocaine reward behaviors are unresolved, and there is no FDA-approved medication for reducing cocaine use or treating relapse. Our research has genetically linked an autophagy- related gene Becn2 to cocaine-induced locomotor stimulation, reward, taking and seeking behaviors. This proposed study will demonstrate for the first time the role and molecular mechanism of the ULK1-Vps34-Becn2 autophagy machinery in the regulation of dopamine 2 receptor metabolism and cocaine abuse.

PI_NAMEs: HE, CONGCONG  (contact);XU, MING

PROGRAM_OFFICER_NAME: TSAI, SHANG-YI ANNE

PROJECT_TERMS: Attenuated;Autophagocytosis;Autoreceptors;Behavior;Behavior Therapy;Behavioral;Binding;Biochemical;Catabolism;Cell Surface Receptors;Cellular biology;Cocaine;Cocaine Abuse;Cocaine Dependence;cocaine reward;cocaine seeking;cocaine use;Complex;conditioned place preference;Corpus striatum structure;craving;Data;Degradation Pathway;Development;Dopamine;Dopamine D2 Receptor;dopaminergic neuron;Dose;Drug abuse;drug of abuse;extracellular;FDA approved;Future;Genes;Genetic;GPRASP1 gene;Homologous Gene;Image;inhibition of autophagy;Intravenous;Knock-out;Knockout Mice;Link;Locomotion;Mass Spectrum Analysis;Metabolism;Molecular;Mus;Mutate;Mutation;Neurons;Neurotransmitters;novel;Output;overdose death;Pathogenicity;Pathway interactions;Pharmaceutical Preparations;pharmacologic;Phenocopy;presynaptic;prevent;Proteins;receptor;Regulation;Relapse;Research;response;reuptake;Rewards;Role;Self Administration;Signal Transduction;Stress;System;targeted treatment;Testing;Time;tool;trafficking;upstream kinase;Vps34 Phosphatidylinositol 3 Kinase;Wild Type Mouse;Work

PROJECT_TITLE: Autophagic regulation of cocaine abuse

STUDY_SECTION: PMDA

STUDY_SECTION_NAME: Pathophysiological Basis of Mental Disorders and Addictions Study Section[PMDA]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

PHR: This proposal seeks five years of de-novo support to enhance and improve an established predoctoral training program in Quantitative Biology and Physiology (QBP). The mission of the QBP Program is to train PhD research scientists who have: (1) a quantitatively based understanding of the principles underlying molecular biology, cell biology and physiology; (2) the capacity to synthesize modern and quantitatively driven experimental methods with biology and physiology; (3) the ability to synthesize mechanistically and structurally based modeling skills with biological and physical systems; and (4) the capacity to assess emergent properties and behavior via integration across multiple length scales of a biological or physiological system or process.

PI_NAMEs: WHITE, JOHN A. (contact)

PROGRAM_OFFICER_NAME: STEPANEK, LAURIE ELIZABETH

PROJECT_TERMS: Biology;Physiology;Training Programs

PROJECT_TITLE: Training Program in Quantitative Biology & Physiology (QBP)

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - A[TWD-A]


ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: Narrative A functioning, well-regulated immune system is essential for the health and wellbeing of each person individually, and collectively. The system is extraordinarily complex, but great advances are being made at an accelerated pace that have tremendous positive impact on people’s health now, through such interventions as vaccines and cancer therapies, as well as enormous promise for greater health gains in the future. Our goal in undertaking the training activities described in this grant proposal is to train the next generation of reseach immunologists in technical skill, scientific judgment, and responsible conduct to become leaders capable of fulfilling the promise of immunological research.

PI_NAMEs: GUMMULURU, SURYARAM  (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Immunology;Research Training

PROJECT_TITLE: Research Training in Immunology

STUDY_SECTION: AITC

STUDY_SECTION_NAME: Allergy, Immunology, and Transplantation Research Committee[AITC]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Orphan Drug;Rare Diseases;Tuberculosis

ORG_CITY: NEW YORK

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: We desperately need new drugs against tuberculosis which is still a major cause of morbidity and mortality worldwide. M. tuberculosis (Mtb) enzymes in central carbon metabolism are emerging as promising targets for drug development but have not been validated in animal models that recapitulate the diverse and heterogeneous environments Mtb encounters in humans. Here we propose to evaluate such drug targets by dissecting the carbon source requirements for Mtb in the model system that is most similar to human Mtb infection and disease.

PI_NAMEs: EHRT, SABINE  (contact);FLYNN, JOANNE L.;SCHNAPPINGER, DIRK

PROGRAM_OFFICER_NAME: ROBINSON, RICHARD THOMAS

PROJECT_TERMS: Affect;Animal Model;Bacteria;Biological Models;Carbon;chronic infection;Development;Disease;Disease Progression;drug development;Drug Targeting;Environment;Enzymes;experience;fatty acid metabolism;Frequencies;Genetic;Gluconeogenesis;Glycolysis;Goals;Granuloma;Growth;Human;In Vitro;Infection;knock-down;Lesion;Lung;Maintenance;Measurement;Metabolic Pathway;Metabolism;Modeling;Morbidity - disease rate;mortality;mouse model;Mus;mutant;mycobacterial;Mycobacterium tuberculosis;new therapeutic target;nonhuman primate;novel therapeutics;Nutritional;Nutritional Requirements;Pathologic;Pathology;Pathway interactions;Persons;PET/CT scan;Phenotype;Phosphoenolpyruvate Carboxylase;Productivity;Reaction;Relapse;Source;Technology;Testing;Therapeutic;Time;Tissues;tool;Tuberculosis;tuberculosis drugs;Validation;Work;X-Ray Computed Tomography

PROJECT_TITLE: M. tuberculosis carbon metabolism during infection

STUDY_SECTION: BV

STUDY_SECTION_NAME: Bacterial Virulence Study Section [BV]


ADMINISTERING_IC: NS

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Chronic Pain;Neurosciences;Pain Research

ORG_CITY: Plano

ORG_NAME: VULINTUS, LLC

PHR: Project Narrative Current methods of assessing somatosensory function in preclinical animal models largely depend on withdrawal responses to uncomfortable or painful stimuli, which do not correspond well to clinical tests of touch and proprioception. In this Phase II STTR project, Vulintus, Inc., continues development of ‘SensiTrak,’ an automated, high-throughput operant behavioral system designed to finely measure somatosensory function in rodent models. SensiTrak systems will provide researchers with unprecedented capabilities to reliably measure tactile and proprioceptive function in early preclinical animal models, and will help to improve the rate of successful translation of promising therapies from preclinical investigations to clinical practice.

PI_NAMEs: SANCHEZ, CAMILO ANDRES (contact)

PROGRAM_OFFICER_NAME: AUBRECHT, TARYN GRACE

PROJECT_TITLE: SensiTrak: Automated Assessment of Forelimb Sensation


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Bioengineering;Cancer;Clinical Research;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Rare Diseases

ORG_CITY: BOSTON

ORG_NAME: BOSTON MEDICAL CENTER

PHR: PROJECT NARRATIVE Oral cancer constitutes a significant worldwide health problem with approximately 448,000 new cases and over a quarter million deaths each year. Complete surgical resection is a critical part of effective treatment and essential for good prognosis. This study will validate the utility of a noninvasive optical technique to differentiate between normal and abnormal tissue which will ultimately help guide surgical margin resection.

PI_NAMEs: GRILLONE, GREGORY A (contact)

PROGRAM_OFFICER_NAME: LOPEZ, ORLANDO

PROJECT_TERMS: Algorithms;Area;Beds;Benign;Biopsy;Blood;Boston;Calibration;cancer cell;Cancer Patient;cancer surgery;Cancerous;Cessation of life;Chemotherapy and/or radiation;Chromatin;Classification;Clinical;Consumption;Costs and Benefits;Data Set;density;design;Diagnosis;diagnostic algorithm;Disease;Disorientation;Dysplasia;effective therapy;Elastic scattering spectroscopy;Enrollment;Evaluation;Excision;experience;Feasibility Studies;Frozen Sections;Functional impairment;Goals;Health;Histologic;Hospitals;improved;In Situ;in vivo;Inflammation;instrumentation;Irrigation;Judgment;Lesion;Light;Light-Scattering Spectroscopy;Malignant - descriptor;malignant mouth neoplasm;Malignant Neoplasms;Measurement;Measures;Medical center;Methodology;Methods;Modality;Morbidity - disease rate;Morphology;mortality;Mucous Membrane;novel;Nuclear;Operating Rooms;Operative Surgical Procedures;Optics;oral care;Oral mucous membrane structure;Oral Stage;Organelles;Pathologic;Pathologist;Pathology;Patients;Performance;portability;Probability;Prognosis;prospective;Protocols documentation;Random Allocation;Recommendation;Recurrence;Reporting;Research;Residual Neoplasm;Residual state;ROC Curve;Saline;Sampling;Sampling Errors;Scanning;Sectioning technique;Side;Site;skip lesion;Specificity;Specimen;Spectrum Analysis;Spottings;success;Surface;Surgeon;Surgical margins;System;Techniques;Technology;Testing;Time;Tissues;tool;Training;tumor;United States;Validation;Visualization;Weight;Work

PROJECT_TITLE: Validation of Light Scattering Spectroscopy for Intra-operative Margin Guidance during Oral Cancer Resection

STUDY_SECTION: IGIS

STUDY_SECTION_NAME: Imaging Guided Interventions and Surgery Study Section[IGIS]


ORG_DEPT: NEUROLOGY

PHR: PROJECT NARRATIVE Peripheral neuropathy is a common complication of diabetes, prediabetes, and obesity, with no effective therapy and unclear mechanisms. In this proposal, we aim to determine the cellular and molecular mechanisms by which lifestyle interventions, such as diet and exercise, can be used to improve peripheral neuropathy by using a high-fat diet mouse model of obesity and prediabetes along with advanced techniques to evaluate Schwann cell-axon metabolic cross talk and energy utilization, nerve-specific molecular contributions, and the effects of insulin and insulin resistance. Together, these studies will advance our understanding of the benefits of lifestyle interventions on metabolically-induced nerve injury, and ultimately unlock potential avenues of investigation for treating PN in diabetes, prediabetes, and obesity to improve the quality of life in affected individuals.

PI_NAMEs: FELDMAN, EVA LUCILLE (contact);HUR, JUNGUK

PROGRAM_OFFICER_NAME: COOKE, BRAD

PROJECT_TERMS: Ablation;Affect;Animal Model;Axon;Bioenergetics;Biological;Cells;Cellular Metabolic Process;Clinical;Coculture Techniques;cohort;Complication;Complications of Diabetes Mellitus;Coupling;Data;Diabetes Mellitus;Diet;diet and exercise;dietary;dietary control;Educational Intervention;effective therapy;Energy consumption;Energy Transfer;Exercise;Failure;Fatty acid glycerol esters;Fatty Acids;Functional disorder;glycemic control;Glycolysis;Goals;Guidelines;Health;High Fat Diet;improved;In Vitro;in vitro Model;in vivo;Individual;Insulin;Insulin Receptor;Insulin Resistance;insulin sensitivity;insulin signaling;Insulin-Like-Growth Factor I Receptor;Interval training;Intervention;Investigation;Knock-out;Knockout Mice;Life Style Modification;lifestyle intervention;Link;lipidome;lipidomics;Metabolic;Metabolic dysfunction;Metabolic Pathway;Metabolic syndrome;Metabolism;metabolomics;Mitochondria;mitochondrial dysfunction;Modeling;Molecular;mouse model;Mus;Muscle;myelination;Nature;Nerve;nerve injury;Nervous System;Neuroglia;Neurons;new therapeutic target;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutic intervention;Obesity;oxidation;Pathway interactions;Patients;Peripheral Nerves;Peripheral Nervous System;Peripheral Nervous System Diseases;Phenotype;Prediabetes syndrome;prevent;Quality of life;Recommendation;Reporting;Research;response;Role;Schwann Cells;sciatic nerve;sex;simulation;single-cell RNA sequencing;Techniques;therapeutic target;Thinness;Tissues;transcriptome;transcriptomics

PROJECT_TITLE: Metabolic coupling between Schwann cells and axons is functionally distinct from myelination and is disrupted in obesity, prediabetes, and diabetes

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biotechnology;Genetics;Infectious Diseases;Natural Products

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: THOMAS JEFFERSON UNIVERSITY

PHR: Project Narrative  We have shown that targeting TrmD, a conserved and essential tRNA methyl transferase in bacteria, reduces protein synthesis in general and biosynthesis of the Gram-negative double-membrane structure in particular, suggesting a dual-strategy to accelerate bactericidal action. While many small molecular compound libraries have been screened to target TrmD, isolated hits lack the cell-permeability necessary to exhibit an antibacterial effect. We propose to screen a large collection of microbial extracts and fractions to target TrmD, using a novel and HTS-ready Ec tolC+ cell-based assay, to identify NPs that are cell-permeable, resistant to efflux, and selective of targeting, which will serve as leads for the next generation of antibiotics with a novel mechanism of action distinct from those currently in clinical use.

PI_NAMEs: HOU, YA-MING  (contact);SHEN, BEN

PROGRAM_OFFICER_NAME: XU, ZUOYU

PROJECT_TERMS: Acceleration;Address;Anabolism;Anti-Bacterial Agents;Antibiotics;Anticodon;Bacteria;bactericide;Binding;Biochemistry;Biological Assay;Biology;Biotechnology;Cell Death;Cell Fraction;Cells;Cellular Assay;Clinical;Codon Nucleotides;Collection;combat;Complement;Complex;Death Rate;Dose;Drug Binding Site;drug discovery;Drug Targeting;efficacy study;efflux pump;Enzymes;Escherichia coli;Exhibits;Fluorescence;Funding;Gene Cluster;Genes;genome database;genome sequencing;Gram-Negative Bacteria;Growth;high throughput screening;Homo sapiens;Human;in vivo;Initiator Codon;Invaded;Libraries;Membrane;Membrane Proteins;Messenger RNA;Methods;Methylation;microbial;Microbial natural product;Mining;Modeling;Modification;Molecular;Multi-Drug Resistance;Natural product discovery;Natural Products;Natural Selections;next generation;Noise;novel;pandemic disease;Penetration;Permeability;Pharmaceutical Preparations;Phenotype;Population;posttranscriptional;premature;Production;programs;Proline;Protein Biosynthesis;Public Health;Pump;Readiness;Reading Frames;Research;Research Institute;Resistance;resistance mechanism;resistance mutation;response;Ribosomes;Risk;Risk Assessment;S-Adenosylhomocysteine;S-Adenosylmethionine;scaffold;scale up;screening;Side;Signal Transduction;Silver;small molecule;Structure;Testing;Time;Transfer RNA;Transferase;Translations

PROJECT_TITLE: TrmD-targeting actinobacterial natural products as next generation antibiotics

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-F(55)R]


ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PI_NAMEs: PORTILLA, DIDIER  (contact)

PROGRAM_OFFICER_NAME: MARIC-BILKAN, CHRISTINE

PROJECT_TERMS: Address;Area;Basic Science;Benign;Biomedical Engineering;Career Choice;Clinical and Translational Science Awards;clinical center;Clinical Research;Clinical Sciences;Data Science;Development;Disease;Doctor of Philosophy;doctoral student;drug discovery;Faculty;functional genomics;Goals;Health;Hematological Disease;Hematology;Historically Black Colleges and Universities;Human;human disease;Immunity;Inflammation;innovation;Institution;Kidney;Kidney Diseases;Lead;Medical;nanotherapeutic;National Research Service Awards;next generation;Physicians;Postdoctoral Fellow;Predictive Analytics;programs;Research;Research Institute;Research Personnel;Research Priority;Research Training;Scientist;Students;Systems Biology;Training;Training and Education;Training Programs;translational health science;Translational Research;Underrepresented Populations;Underrepresented Students;Universities;Urologic Diseases;Urology;Virginia

PROJECT_TITLE: IGNITE KUH NRSA Training Core


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Clinical Research;Mental Health;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Social Determinants of Health

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: RELEVANCE TO PUBLIC HEALTH This study is designed to improve our understanding of the changes in brain structure and function that underlie the elevated rates of social impairments now increasingly recognized in prematurely-born children. Using cutting- edge magnetic resonance imaging methods, we will investigate these relationships in a unique, longitudinally- studied cohort of very preterm and term-born children with high rates of psychosocial adversity now reaching age 14-15 years and previously studied using advanced neuroimaging and detailed assessments of neurodevelopment and psychiatric symptoms across childhood. The overarching goal is the development of new approaches for earlier, more accurate identification of children at risk for social impairments, enabling progress toward targeted interventions which improve outcomes by limiting risks for psychopathology associated with prematurity and psychosocial adversity.

PI_NAMEs: ROGERS, CYNTHIA ELISE (contact);SMYSER, CHRISTOPHER DANIEL

PROGRAM_OFFICER_NAME: CORNELL, ASHLEY ROSE

PROJECT_TERMS: Adolescence;Adolescent;Adult;Age;aged;Anisotropy;autism spectrum disorder;Behavior;Birth;Brain;Cerebellum;Child;Childhood;cohort;Cohort Effect;Collection;critical period;Data;design;Development;Diffusion Magnetic Resonance Imaging;Dimensions;Disease;early childhood;Early Intervention;Emotional;emotional functioning;Evaluation;Evolution;Executive Dysfunction;executive function;Exhibits;extreme prematurity;Functional disorder;Functional Magnetic Resonance Imaging;Goals;Growth;high risk;imaging modality;Impairment;improved;improved outcome;Individual;infancy;informant;innovation;Intervention;Interview;Investigation;Knowledge;Lead;Link;Longitudinal cohort;Longitudinal cohort study;Magnetic Resonance Imaging;Measures;Mediating;Methodology;middle childhood;Modeling;MRI Scans;multimodality;Nature;Neonatal;neonatal period;neurodevelopment;neuroimaging;non-genetic;novel strategies;Pattern;peer;peer victimization;Play;predictive modeling;Pregnancy;premature;Premature Birth;preventive intervention;Process;prospective;Prospective cohort;psychiatric symptom;Psychopathology;psychosocial;Public Health;Reporting;Rest;Risk;Risk Factors;risk mitigation;Role;School-Age Population;sex;Shapes;social;Social Adjustment;social cognition;social communication;social deficits;Social Functioning;Social Interaction;social skills;sociodemographics;stem;Structure;Symptoms;Techniques;temporal measurement;Testing;Variant;white matter

PROJECT_TITLE: Trajectories of Cortico-Cerebellar Connectivity, Social Competence, and Internalizing Symptoms in Adolescents Born Very Preterm


PI_NAMEs: ISAKOVA, TAMARA  (contact)

PROJECT_TITLE: NRSA Training Core


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Genetics;Liver Cancer;Liver Disease;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: WYNNEWOOD

ORG_NAME: LANKENAU INSTITUTE FOR MEDICAL RESEARCH

PHR: PROJECT NARRATIVE This study intends to determine the cellular and molecular mechanisms of HepatoCellular Carcinoma (HCC) initiation upon unrestricted E2f activity. In particular, we will test the hypothesis that E2f activity in a committed periductal progenitor alters its cellular fate to serve as a cell of origin for HCC.

PI_NAMEs: VIATOUR, PATRICK  (contact)

PROGRAM_OFFICER_NAME: MAAS, STEFAN

PROJECT_TERMS: Affect;analytical tool;antagonist;Automobile Driving;Back;Biological Assay;Cancer Biology;cancer initiation;Carcinogens;Cell Cycle;Cell Differentiation process;cell fate specification;Cell Lineage;Cells;Cessation of life;Classification;Clinical;Couples;Data;Development;Disease Progression;Duct (organ) structure;epigenomics;Event;Family;Frequencies;functional genomics;Gene Family;Genes;Genetic;Genetic Transcription;Genomics;Goals;Growth;Hepatocyte;Human;human disease;in vivo;Incidence;Individual;individualized medicine;Knock-out;Knowledge;Lesion;Liver;liver cancer model;Malignant Neoplasms;Methylation;Modeling;Molecular;mortality;Mus;Nature;neoplastic cell;novel;Oncogenic;Oncoproteins;Organoids;overexpression;Pathogenesis;Pathway interactions;Patients;Pattern;pharmacologic;Population;Primary carcinoma of the liver cells;progenitor;Proliferating;promoter;Protein Family;Repression;Resistance;Retinoblastoma Protein;Role;Sampling;Second Primary Cancers;Series;Signal Transduction;single-cell RNA sequencing;Source;stem cell population;Testing;Therapeutic;therapy development;transcription factor;tumor;tumor initiation;tumorigenesis;Validation;Viral

PROJECT_TITLE: Mechanisms of tumor initiation upon disruption of the Rb/E2f interaction

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Complementary and Integrative Health;Genetics;Neurosciences

ORG_CITY: NEW HAVEN

ORG_DEPT: NEUROSCIENCES

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative  How our brain precisely senses and responds to changes from the body's visceral organs remains a mystery. The research proposed here will determine the molecular, functional, and anatomical architecture of the vagus nerve, a major interoceptive system and a key body-brain axis using state-of-the-art molecular and genetic approaches. This planned study will vertically advance our understanding of interoception, the senses from inside the body, and may inspire the development of novel targets and strategies to improve human health.

PI_NAMEs: CHANG, RUI  (contact)

PROGRAM_OFFICER_NAME: CHEN, WEN G

PROJECT_TERMS: Afferent Neurons;Anatomy;Architecture;Area;Brain;brain pathway;Calcium;Cells;Code;Collection;combinatorial;Complex;Computational Biology;Data;Development;Dimensions;Disease;Dissection;Electrophysiology (science);Environment;Fluorescent in Situ Hybridization;Foundations;Genetic;genetic approach;Genetic Code;Genetic Heterogeneity;genetic profiling;genetic signature;Genetic Techniques;Goals;Health;Heart;high throughput analysis;Human;Image;improved;in vivo;Individual;innovation;innovative technologies;Interoception;Knowledge;Location;Lung;Modality;Molecular;neglect;neural circuit;neurochemistry;Neurons;neuroprotection;Neurosciences;novel;novel strategies;Organ;Outcome;parallel processing;Pathway interactions;Peripheral;Physiological;Physiology;Property;Regulation;Research;response;segregation;Sensory;sensory input;sensory mechanism;Signal Transduction;Signal Transduction Pathway;Specific qualifier value;Stimulus;Stomach;Stream;Stretching;System;therapeutic target;Time;Tissues;tool;transcriptomics;transmission process;Vagus nerve structure;Visceral

PROJECT_TITLE: Understanding the molecular and functional architecture of diverse body-brain pathways

STUDY_SECTION: NIC

STUDY_SECTION_NAME: Neuroscience of Interoception and Chemosensation Study Section[NIC]


ORG_DEPT: PHYSIOLOGY

PHR: Mechanisms of chromosome motility during mammalian meiosis Narrative Meiosis is a form of cell division that gives rise to sperm and ova for reproduction, and errors in this process can lead to infertility, miscarriage, and congenital disorders. This project will dissect the molecular underpinnings of an essential step in meiosis orchestrated by the joint action of nuclear envelope-associated and dynein complexes in the cell and reveal how a mutation in this complex results in infertility. These studies will provide fundamental insights into dynein biology and meiosis and bear implications for infertility diagnosis and treatment.

PI_NAMEs: NANDAKUMAR, JAYAKRISHNAN  (contact)

PROGRAM_OFFICER_NAME: TAYMANS, SUSAN

PROJECT_TERMS: Adopted;Applications Grants;Architecture;Back;Binding;Biochemical;Biological Models;Biology;biophysical techniques;Cell division;Cell Nucleus;cell type;Cells;Chromosome Segregation;Chromosomes;Complement;Complex;Congenital Abnormality;Congenital Disorders;Cytoskeletal Proteins;Cytoskeleton;Cytosol;Data;daughter cell;Diagnosis;Dissection;DNA;Dynein ATPase;Electrons;Ensure;Event;Fertility;Fertility Disorders;Genes;Genetic Crossing Over;Genetic Recombination;Genetic Variation;Germ Cells;Germ Lines;Haploidy;Higher Order Chromatin Structure;Homologous Gene;Human;improved;In Vitro;in vitro Assay;in vivo;Infertility;infertility treatment;insight;interdisciplinary approach;Investigation;Joints;Knowledge;Light;Link;live cell microscopy;Mammals;Meiosis;Meiotic Prophase I;Membrane;Membrane Proteins;Microscopy;Microtubules;Molecular;molecular modeling;Motility;Motion;Mus;Mutation;Nuclear;Nuclear Envelope;Nuclear Outer Membrane;Organ;Ovum;Positioning Attribute;Preparation;prevent;Process;Production;Protein Biochemistry;protein protein interaction;protein reconstitution;Proteins;Qualifying;reconstitution;recruit;Reproduction;Reproductive Biology;Risk Factors;segregation;Sexual Reproduction;Side;single molecule;Specificity;sperm cell;Spermatocytes;Spontaneous abortion;Structure;telomere;Testis;Total Internal Reflection Fluorescent;transmission process

STUDY_SECTION: NCSD

STUDY_SECTION_NAME: Nuclear and Cytoplasmic Structure/Function and Dynamics Study Section[NCSD]


NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Genetics;Human Genome;Macular Degeneration;Neurodegenerative;Neurosciences;Prevention;Tobacco;Tobacco Smoke and Health

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative Age-related macular degeneration (AMD), the most common cause of blindness among the elderly and without a cure for early disease, is initiated by retinal pigment epithelial (RPE) degeneration. Variation in the RPE degeneration is well recognized in early AMD, but how it causes AMD is unknown. This proposal will determine the extent that RPE heterogeneity causes the conversion from aging to early AMD.

PI_NAMEs: HANDA, JAMES T (contact)

PROGRAM_OFFICER_NAME: SHEN, GRACE L

PROJECT_TERMS: Address;Age related macular degeneration;Aging;Antioxidants;Apoptosis;ATAC-seq;Atherosclerosis;Bioinformatics;Biological Markers;Biological Process;Blindness;Cells;Cessation of life;Characteristics;Chromatin;chromatin modification;Chronic;cigarette smoke;Complex;Cytoprotection;Development;Disease;effective therapy;Elderly;Environmental Exposure;Environmental Risk Factor;Enzymes;Epigenetic Process;epigenome;Exposure to;exposure to cigarette smoke;Eye;Financial cost;Financial Hardship;Functional disorder;Genes;Genetic;genetic information;Genetic Transcription;Genetic Variation;Genomics;Genotype;HDAC11 gene;Heterogeneity;high risk;Immune response;Immunofluorescence Immunologic;Immunohistochemistry;Individual;induced pluripotent stem cell;inhibitor;Kinetics;Life;Link;Location;macula;Malignant Neoplasms;Minnesota;Minority;Mitochondria;Modeling;Modification;Mus;Mutation;Nerve Degeneration;non-smoker;overexpression;Pathogenesis;Pathogenicity;Pathologic;Pathway interactions;Peripheral;Phenotype;prevent;programs;Promoter Regions;response;Retina;Retinal Diseases;retinal rods;Risk Factors;Role;Signal Transduction;single cell ATAC-seq;single-cell RNA sequencing;Smoke;Smoker;Smoking;Spatial Distribution;Stress;Structure of retinal pigment epithelium;System;Tissues;transcriptome;transcriptome sequencing;transcriptomics;Variant;Visualization;Work;XCL1 gene

PROJECT_TITLE: The role of epigenetics in RPE heterogeneity with early AMD

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Data Science;Disability Research;Emergency Care;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Patient Safety;Physical Injury - Accidents and Adverse Effects;Prevention;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: DURHAM

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Project Narrative Traumatic brain injury (TBI) affects the lives of an estimated 5 million patients each year, but it is notoriously difficult to treat due to great complexities in diagnosis and prognosis. We will leverage large-scale EHR data from 17 hospitals across two healthcare systems to train, deploy, and prospectively validate a cutting edge deep learning model that uses real-time discrete patient data and raw CT image volumes to predict patient risk for a set of key actionable TBI complications. By referring to the model’s interpretable predictions and how they change across time, frontline providers in emergency rooms, in-patient units, and neurosurgery units will make better decisions about treatment and withdrawal of care, meaning the threat of this ubiquitous and devastating condition will be minimized.

PI_NAMEs: DUNN, TIMOTHY WILLIAM (contact)

PROGRAM_OFFICER_NAME: UMOH, NSINI ALEASE

PROJECT_TERMS: Accident and Emergency department;Admission activity;Affect;American;Brain;Caring;Categories;Cause of Death;Clinical;clinical care;clinical implementation;clinical risk;Clinical Trials;cohort;Collaborations;combat;Complex;Complication;computer infrastructure;cost;Country;dashboard;Data;data infrastructure;Data Set;data warehouse;Databases;Decision Making;deep learning model;deep neural network;demographics;design;Diagnosis;disability;discrete time;Early Diagnosis;Emergency Care;Environment;Epidemic;experience;experimental study;explainable machine learning;Future;Goals;Health system;Healthcare;Healthcare Systems;Hemorrhage;Hospitals;Hour;improved;Inflammation;Infrastructure;Injury;Inpatients;Institution;Intervention;Left;machine learning model;Medical History;Mental disability;Methods;mild traumatic brain injury;model building;Modeling;Modernization;Monitor;network architecture;neural network architecture;Neural Network Simulation;Neurologic;neuron loss;neurosurgery;Outcome;Output;Pathway interactions;Patient risk;Patient-Focused Outcomes;Patients;Performance;physically handicapped;predictive modeling;predictive tools;Procedures;Process;Prognosis;prognostic model;prospective;Prospective cohort;Provider;readmission rates;real-time images;Resources;Risk;risk prediction;Running;Secure;Sensitivity and Specificity;Site;TBI Patients;TBI treatment;Technology;Testing;Time;tool;Training;Training and Education;training data;Trauma;Traumatic Brain Injury;treatment guidelines;Triage;United States;Universities;Update;Validation;Withdrawal;Work;X-Ray Computed Tomography;young adult

PROJECT_TITLE: Building and implementing a TBI prognostic model featuring real-time analysis of brain CT images

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Networking and Information Technology R&D (NITRD);Prevention;Social Determinants of Health;Stimulant Use and Misuse;Substance Misuse;Telehealth

ORG_CITY: STORRS-MANSFIELD

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF CONNECTICUT STORRS

PHR: Narrative  The proposed research focuses on first understanding MSM's preferences of specific attributes of PrEP delivery programs, followed by developing and testing a smartphone app to deliver a combination HIV prevention intervention that incorporates pre-exposure prophylaxis among MSM. Findings will inform the development of innovative and tailored primary HIV prevention strategies to address co-occurring sexual and drug risk behaviors and to enhance the HIV prevention gap in Malaysian MSM.

PI_NAMEs: SHRESTHA, ROMAN  (contact)

PROGRAM_OFFICER_NAME: JENKINS, RICHARD A

PROJECT_TERMS: Acceleration;Acquired Immunodeficiency Syndrome;Address;Age;AIDS prevention;amphetamine use;Amphetamines;Applied Skills;Area;Asia;biobehavior;Biometry;Career Choice;Career Mobility;Caring;Cellular Phone;Clinic;comparative effectiveness trial;Competence;Country;Coupled;Decision Making;Development;Diffusion;Discrimination;Drug usage;Ensure;Environment;Epidemic;experience;Fostering;Foundations;Fright;Funding;Future;Goals;Guide prevention;Health;health communication;Health Professional;Health Promotion;Health Services;Health Technology;Healthcare;high risk;HIV;HIV Infections;Homosexuality;Human immunodeficiency virus test;improved;Incidence;Income;information gathering;innovation;interest;International Agencies;Intervention;Interview;Judgment;Laws;Link;Malaysia;Malaysian;marginalization;men;men who have sex with men;Mentors;Mentorship;Methods;mHealth;mobile computing;Motivation;Muslim population group;Patient Preferences;Patients;Persons;Pharmaceutical Preparations;Phase;Physicians;pilot test;Population;pre-exposure prophylaxis;preference;Prevalence;Prevention;prevention service;Prevention strategy;preventive intervention;Productivity;programs;Provider;provider communication;public health research;Recommendation;Research;Research Activity;Research Personnel;Research Project Grants;Risk;Risk Behaviors;scale up;Science;service delivery;Services;sex;Sexual Health;Sexual Transmission;Sexuality;skills;smartphone application;Social Discrimination;social stigma;Statutes and Laws;Stigmatization;Stimulant;stimulant use;Strategic Planning;Study models;substance use;Substance Use Disorder;Surveys;syndemic;Testing;therapy design;therapy development;Training;Translating;transmission process;Unsafe Sex;uptake;virtual;Vulnerable Populations;Work

PROJECT_TITLE: Training in MHealth Prevention with MSM

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


NIH_SPENDING_CATS: Biotechnology;Diabetes;Regenerative Medicine;Wound Healing and Care

ORG_CITY: TUCSON

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: Project Narrative Non-healing wounds in diabetic patients represent a challenging clinical problem that often results in amputation. The long-term goal of our research is to develop small molecule therapeutics to effectively promote healing of diabetic wounds. The objective of this work is to determine the ability of our novel small molecule CXCR4 agonists to correct the diabetic wound healing impairment in vivo, optimize the formulation and pharmacokinetics in vitro and in vivo using a medicinal chemistry approach, determine the mechanisms of action, and then extend these observations to the clinically relevant porcine model.

PI_NAMEs: LIECHTY, KENNETH W (contact);MALANY, SIOBHAN ;XU, JUNWANG

PROGRAM_OFFICER_NAME: LI, YAN

PROJECT_TERMS: Acceleration;Agonist;Amputation;analog;angiogenesis;Animals;Architecture;Area;Binding;Biological Assay;chemokine;Chemotaxis;Clinical;clinical application;clinically relevant;Collagen;commercialization;counterscreen;CXCR4 gene;CXCR4 Receptors;CXCR4 Signaling Pathway;Data;Diabetes Mellitus;diabetic;diabetic patient;diabetic ulcer;diabetic wound healing;Drug Kinetics;effective therapy;Epidemic;Epithelium;Fibroblasts;Formulation;Gene Expression;Goals;Granulation Tissue;healing;Health Expenditures;Histology;Human;Immunohistochemistry;Impaired wound healing;Impairment;improved;In Vitro;in vivo;in vivo evaluation;Individual;Inflammation;Injections;Lead;lead optimization;Libraries;Lower Extremity;Measurement;Measures;Mediating;Messenger RNA;metabolic abnormality assessment;MicroRNAs;migration;Migration Assay;mouse model;Mus;non-healing wounds;novel;novel therapeutics;Oxazoles;Pathway interactions;Patient-Focused Outcomes;Permeability;Pharmaceutical Chemistry;porcine model;pre-clinical;Production;Proteins;recruit;Research;scaffold;screening;Series;Skin;Skin wound healing;small molecule;small molecule therapeutics;Societies;stem cells;Structure-Activity Relationship;Testing;Toxic effect;United States;United States National Institutes of Health;Western Blotting;Work;wound;wound closure;wound healing;Wound models

PROJECT_TITLE: Advancing small molecule CXCR4 agonists for diabetic wound healing

STUDY_SECTION: ACTS

STUDY_SECTION_NAME: Arthritis, Connective Tissue and Skin Study Section[ACTS]


NIH_SPENDING_CATS: Chronic Pain;Clinical Research;Contraception/Reproduction;Endometriosis;Estrogen;Pain Research;Precision Medicine;Women's Health Research

ORG_CITY: HOUSTON

ORG_DEPT: PATHOLOGY

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: PUBLIC HEALTH RELEVANCE STATEMENT Increasingly the role of drug discovery and development of novel treatments for endometriosis are emerging from academic groups as pharma interest in common and morbid women’s health indications declines. The current effort addresses an NICHD mandate of the Gynecologic Health & Disease Branch to identify and develop novel non-hormonal therapeutic agents for treatment of gynecologic pain syndromes, and engages transdisciplinary participation of reproductive biologists, immunologists, medicinal chemists, pharmacologists, biomedical engineers and entrepreneurs. Our collective experience integrates early adoption of biomarker and therapeutic co-development strategies to bring novel drug-like inhibitors of Jun-N- terminal kinase to targeted patient populations of women seeking new alternatives to control endometriosis as stand-alone therapies, or as sequential treatment during the required hiatus following hormone antagonists.

PI_NAMEs: MONSIVAIS, DIANA  (contact)

PROGRAM_OFFICER_NAME: AHN, HELENA HYESOOK

PROJECT_TERMS: Address;Adoption;Affect;Affinity;Agonist;analog;Animal Model;antagonist;Anti-Inflammatory Agents;Aromatase;Autologous;Biological Markers;biomarker panel;Biomedical Engineering;Cells;Chemistry;Clinical;Clinical Research;college;Companions;comparative efficacy;Contraceptive Agents;cytokine;Development;Diagnostic;diagnostic technologies;Disease;Disease Management;DNA;drug development;drug discovery;Endocrine;Endometrial;Endometrial Stromal Cell;Endometriomas;endometriosis;Endometrium;Enzymes;Epithelium;Equilibrium;established cell line;Estrogen Antagonists;Estrogens;eutopic endometrium;Evaluation;experience;Fibroblasts;Foundations;Functional disorder;Funding;Future;genotoxicity;Gonadotropin Hormone Releasing Hormone;Greater sac of peritoneum;Growth;Gynecologic;Health;Hormonal;Hormone Antagonists;Hormones;Human;hypothalamic pituitary ovarian axis;Immune;immune function;immunological status;Immunologist;Immunosuppression;improved;In Vitro;Infertility;Infiltration;Inflammation;Inflammatory;inhibitor;Innate Immune Response;interest;Interruption;kinase inhibitor;Leadership;Lesion;Libraries;Macrophage;MAPK8 gene;Marketing;Mediating;Medicine;Medroxyprogesterone 17-Acetate;Mesenchymal;Metabolic;Modeling;mouse model;Mus;N-terminal;National Institute of Child Health and Human Development;Natural Killer Cells;nonhuman primate;novel;novel therapeutics;Oral;overexpression;Pain;Pain management;pain perception;pain symptom;Pain Threshold;Pathologic;Pathology;Pathway interactions;patient population;patient stratification;Patients;Peptides;Peritoneal;Permeability;Pharmaceutical Preparations;Pharmacologic Substance;Phase;Phosphotransferases;pre-clinical;Pre-Clinical Model;preclinical study;Primates;Production;Productivity;Progesterone;Progesterone Receptors;programs;public health relevance;Reporting;reproductive;Research;Resistance;responders and non-responders;response;Rodent;Role;Sequential Treatment;side effect;Stratification;Surveys;Syndrome;targeted treatment;Technology;technology platform;Testing;Therapeutic;Therapeutic Agents;transdifferentiation;Treatment Efficacy;United States;Uterus;Woman;Women's Health

PROJECT_TITLE: Discovery and development of potent inhibitors of Jun N-terminal kinase for non-hormonal treatment of endometriosis and associated pain

STUDY_SECTION: ICER

STUDY_SECTION_NAME: Integrative and Clinical Endocrinology and Reproduction Study Section[ICER]


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Heart Disease;Patient Safety;Prevention;Primary Health Care;Social Determinants of Health;Telehealth

ORG_CITY: EAST LANSING

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: MICHIGAN STATE UNIVERSITY

PHR: PROJECT NARRATIVE 21-42% of patients with diabetes mellitus (DM) do not adhere to their medications, incurring a staggering lost opportunity for health. The proposed research will evaluate the effectiveness of novel approaches incorporating mobile technology and patient activation interventions, to achieve sustainable medication adherence, with the goal of preventing cardiovascular disease and its outcomes in minority and low-income populations with DM. This project directly addresses the NIH Adherence Network PA-18-722 FOA call for studies of adherence- promoting intervention research that address patient adherence to treatment and prevention regimens to promote health outcomes.

PI_NAMEs: OLOMU, ADESUWA B (contact)

PROGRAM_OFFICER_NAME: REDMOND, NICOLE

PROJECT_TERMS: Address;Adherence;Adoption;Adult;attentional control;Blood Glucose;Blood Pressure;blood pressure control;burden of illness;Cardiovascular Diseases;cardiovascular disorder prevention;cardiovascular disorder risk;care providers;Caring;Cellular Phone;Cessation of life;Cholesterol;Chronic Disease;Client satisfaction;Clinic;Clinic Visits;Clinical;clinical practice;Clinical Trials;Collaborations;Communication;Communities;Complex;Consolidated Framework for Implementation Research;cost;Cost Savings;Diabetes Mellitus;diabetic patient;disease disparity;Disease Outcome;disparity elimination;Effectiveness;effectiveness evaluation;Electronics;Enrollment;Ensure;Evaluation;Federally Qualified Health Center;Fostering;Frequencies;Goals;Guidelines;Health;Health Care Costs;health care service utilization;Health Personnel;Health Promotion;health service use;Health system;implementation barriers;implementation facilitators;implementation process;improved;improved outcome;innovation;Intervention;Intervention Studies;Investments;K-Series Research Career Programs;Knowledge;Lead;Low income;Low Income Population;low socioeconomic status;Maintenance;Measures;Mediator;medication compliance;medication nonadherence;Methods;mHealth;mhealth interventions;Michigan;microcosting;Minority;minority patient;mobile computing;Modeling;Monitor;Morbidity - disease rate;mortality;Non-Insulin-Dependent Diabetes Mellitus;novel strategies;Office Visits;Outcome;Patient Care;Patient Compliance;patient oriented;Patient Self-Report;patient-clinician communication;Patients;Pharmaceutical Preparations;Physicians;Pilot Projects;Population;prevent;Prevention;primary care clinic;primary care setting;primary outcome;programs;prospective;protocol development;Provider;Psychological reinforcement;Public Health;Qualifying;Questionnaires;Randomized;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;recruit;Regimen;Research;Risk;safety net;satisfaction;secondary outcome;Self Management;Services;shared decision making;standard of care;Testing;Text Messaging;text messaging intervention;Training;Translating;treatment as usual;United States National Institutes of Health;Vulnerable Populations

PROJECT_TITLE: Improving Diabetic Patients’ Adherence to Treatment and Prevention of Cardiovascular Disease

STUDY_SECTION: BMIO

STUDY_SECTION_NAME: Behavioral Medicine, Interventions and Outcomes Study Section[BMIO]