NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Mental Health;Neurosciences;Opioid Misuse and Addiction;Opioids;Pediatric;Post-Traumatic Stress Disorder (PTSD);Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Narrative The US is dealing with an opioid crisis; up to 11 million people are misusing their prescription opioids, leading to high rates of overdose and death. While adverse childhood experiences are a risk factor for opioid misuse and opioid use disorder, the neurocognitive pathways underlying this link are not known. This project will test the hypothesis that hippocampal-associated context-dependent learning and memory is a crucial link between adverse childhood experiences and opioid use disorder, with findings informing efforts to create individually tailored prevention and treatment to reduce opioid misuse and overdose.

PI_NAMEs: DUVAL, ELIZABETH  (contact)

PROGRAM_OFFICER_NAME: MOLLICK, JESSICA ANN

PROJECT_TERMS: Adult;adverse childhood events;Amygdaloid structure;Animals;Anxiety;anxiety symptoms;associated symptom;Behavioral;Brain;brain based;Buprenorphine;Cessation of life;Chronic Disease;chronic pain;Clinical;Cognitive;common symptom;comorbidity;Complex;conditioned fear;Control Groups;cost;Cross-Sectional Studies;Cues;Dangerousness;depressive symptoms;design;Detection;Development;disorder risk;Disparate;Emotional;emotional functioning;experience;Foundations;Functional disorder;Future;Hippocampus;Hormones;Individual;Injury;Investigation;Learning;Link;Longitudinal Studies;Measures;Medical;Memory;Mental Depression;Mental disorders;Modeling;Modernization;mortality;neural;Neurocognitive;Neurocognitive Deficit;Neurons;Neurosciences;Opioid agonist;opioid epidemic;opioid misuse;opioid overdose;opioid use;opioid use disorder;Outcome;Overdose;Pain Disorder;Panthera leo;Pathway interactions;Patient Self-Report;Patients;Performance;Persons;Population;Post-Traumatic Stress Disorders;Prefrontal Cortex;prescription opioid;Prevention;Process;programs;psychiatric symptom;Public Health;recruit;remediation;Rewards;Risk;Risk Factors;risk sharing;Sampling;Severities;Shapes;Stress;stress related disorder;Structure;substance use;Substance Use Disorder;surgical pain;Testing;tool;Trauma;way finding;Work

PROJECT_TITLE: A mechanistic investigation of risk factors for opioid use disorder: Examining hippocampal-based context-dependent learning and memory associated with adverse childhood experiences

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


ADMINISTERING_IC: GM

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_CITY: NEW YORK

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

ORG_STATE: NY

PHR: Genome duplication and repair require complex regulation. These regulatory mechanisms have broad influence on human diseases, ranging from developmental deficiency to cancers. Our work will use a combination of approaches to understand how cells ensure completion of replication, removal of DNA repair intermediates, and turning off the genome stress response at the right time.

PI_NAMEs: ZHAO, XIAOLAN  (contact)

PROGRAM_OFFICER_NAME: REDDY, MICHAEL K

PROJECT_TERMS: Area;biological adaptation to stress;Cells;Collaborations;Complex;coping;coping mechanism;Coupled;Cruciform DNA;Development;Disease;DNA;DNA biosynthesis;DNA Damage;DNA damage checkpoint;DNA Repair;DNA replication fork;DNA Structure;Ensure;Enzymes;Excision;Failure;Genetic Recombination;Genome;Genome Stability;Genomics;Goals;Growth;homologous recombination;human disease;insight;interdisciplinary approach;Joints;Licensing;Link;Malignant Neoplasms;Molecular;novel;novel strategies;Outcome;Pathway interactions;prevent;Process;Regulation;repaired;Research;response;Ribosomal DNA;Role;Signal Transduction;Site;Stress;Testing;Time;Work

PROJECT_TITLE: Regulation of genome replication, recombination, and stress response

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Bioengineering;Dental, Oral, and Craniofacial Disease;Neurosciences;Temporomandibular Muscle/Joint Disorder (TMJD)

ORG_CITY: BALTIMORE

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Proprioception is a critical sensory modality for feedback control of motor actions. How mechanosensory signals at primary proprioceptors and motor commands interact is incompletely understood. This project uses the unique advantages of jaw proprioceptors to elucidate how proprioceptive signals are modulated by motor commands and build a quantitative model of jaw proprioception during active movements.

PI_NAMEs: KIM, JEONG JUN  (contact)

PROGRAM_OFFICER_NAME: FUQUA, CHANTEL FAYSAN

PROJECT_TERMS: Affect;Anesthesia procedures;awake;Behavior;Biomechanics;body position;body sense;Cell Nucleus;Code;Complex;computer framework;control theory;Coupling;craniofacial structure;Dedications;density;design;Electrophysiology (science);Elements;Feedback;Fiber;flexibility;Gamma Motor Neurons;Goals;hindbrain;in vivo;Jaw;jaw movement;kinematics;Length;Masticatory muscles;mechanical force;mechanical signal;Mechanics;Modality;Modeling;Monitor;Motion;Motor;motor control;Motor Cortex;Motor output;Movement;Mus;Muscle;Muscle Spindles;Musculoskeletal;Nature;nerve supply;neural;neural model;neuromechanism;Neurons;Noise;novel;optogenetics;orofacial;Orofacial Pain;Parents;Pattern;Process;Property;Proprioception;Proprioceptor;receptor;Regulation;Rodent;sensor;sensorimotor system;Sensory;Signal Transduction;Source;Stretching;System;Temporomandibular Joint Disorders;Testing;tool;Training;Trigeminal Nuclei;Trigeminal System;Work

PROJECT_TITLE: Quantitative model of jaw proprioception during active movements

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


ADMINISTERING_IC: CA

ED_INST_TYPE: HOSPITALS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Immunotherapy;Lung;Lung Cancer;Orphan Drug;Precision Medicine;Rare Diseases

ORG_CITY: HOUSTON

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: PROJECT NARRATIVE Small cell lung cancer (SCLC) is an aggressive malignancy epitomized by rapid relapse and pervasive, insurmountable treatment-resistance with a major unmet need to study mechanisms underlying this resistance. To address this, Dr. Allison Stewart (Research Specialist), a Research Scientist with Dr. Lauren Byers (Unit Director) at M.D. Anderson Cancer Center, has established a SCLC repository for patient circulating tumor cell (CTC)-derived xenograft (CDX) models and has supervised the collection and analysis of patient liquid and tumor biopsies for innovative genomic, transcriptomic and proteomic analyses to study adaptations driving treatment resistance in SCLC. These efforts have demonstrated with single-cell resolution that treatment resistance involves a dynamic process of shifting gene expression profiles to generate an increasingly heterogeneous tumor with multiple, concurrent mechanisms of resistance.

PI_NAMEs: STEWART, CATHERINE ALLISON (contact)

PROGRAM_OFFICER_NAME: FORRY, SUZANNE L

PROJECT_TERMS: Address;Animal Model;Automobile Driving;Bioinformatics;Biological Assay;Biological Specimen Banks;Biopsy;Blood;cancer biomarkers;Cancer Center;Cancer Model;Cells;Chemoresistance;chemotherapy;Chest;Clinical;Clinical Trials;Collection;Consent;design;Development;Disease;Disparate;Doctor of Medicine;Drug resistance;experimental analysis;experimental study;Gene Expression Profile;Gene Expression Profiling;Generations;Genomics;Goals;Head and neck structure;Heterogeneity;Immunotherapy;innovation;Investigation;Laboratories;liquid biopsy;Liquid substance;longitudinal analysis;Malignant Neoplasms;Medical Oncology;Methods;Modeling;multidisciplinary;Neoplasm Circulating Cells;new therapeutic target;novel;Outcome;patient derived xenograft model;patient response;Patients;Platinum;Population;Process;Proteomics;Refractory;Relapse;relapse patients;repository;Research;Resistance;resistance mechanism;Resolution;response;Sampling;Scientist;single cell analysis;single-cell RNA sequencing;Site;small cell lung carcinoma;Specialist;Specimen;standard of care;targeted treatment;Texas;therapy resistant;Time;Tissue Sample;Tissues;transcriptomics;tumor;tumor heterogeneity;Universities;University of Texas M D Anderson Cancer Center;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Modeling tumor heterogeneity and treatment resistance in small cell lung cancer


ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: NARRATIVE  Radiation therapy applied to one tumor has the ability to induce anti-tumor T cell responses that, in combination with immune checkpoint blockade therapy, cause systemic tumor regression. The goal of this proposal is to understand the mechanisms that enable the immune response elicited at the irradiated tumor site to be effective against non-irradiated metastases. This information will fill knowledge gaps about the role of radiotherapy in enhancing responses to immunotherapy, and possibly identify candidate biomarkers and actionable targets to improve cancer patients selection and treatment.

PI_NAMEs: DEMARIA, SANDRA  (contact)

PROGRAM_OFFICER_NAME: PRASANNA, PAT G

PROJECT_TERMS: Abscopal effect;Activated Natural Killer Cell;Adaptor Signaling Protein;Address;anti-CTLA-4 therapy;Antigens;Autoimmunity;Automobile Driving;Blood;cancer cell;Cancer Patient;candidate identification;candidate marker;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;cell type;checkpoint therapy;chemokine;Circulation;Cross Presentation;Cytosol;Data;Dendritic Cells;Disseminated Malignant Neoplasm;Distal;DNA;DNA Binding;DNA Damage;DNA Methylation;Dose;effector T cell;Exposure to;extracellular vesicles;Fostering;fractionated radiation;Generations;Goals;Growth Factor;Home;Human;Hybrids;IFNAR1 gene;Immune;immune checkpoint blockade;Immune response;immunogenic;Immunotherapy;Impairment;improved;in situ vaccine;in vitro testing;in vivo;Infiltration;Interferon Activation;Interferon Type I;Interferon-beta;Interferons;Intervention;ipilimumab;Irradiated tumor;knock-down;Knowledge;Literature;Malignant neoplasm of lung;Mediating;micronucleus;Mitochondrial DNA;Mus;Mutation;Natural Killer Cells;Neoplasm Metastasis;NK Cell Activation;novel;Nucleic Acids;overexpression;Pathway interactions;patient response;Patient Selection;Patients;Phenotype;Play;Pre-Clinical Model;Process;Production;pseudotoxoplasmosis syndrome;Publishing;Radiation;radiation response;Radiation therapy;recruit;response;RNA;Role;Sampling;Second Messenger Systems;Serum;Signal Transduction;single cell analysis;Site;Stimulator of Interferon Genes;Stimulus;T cell response;T-Cell Activation;T-Lymphocyte;Testing;tumor;tumor microenvironment;Tumor Promotion;Tumor-infiltrating immune cells;Work

PROJECT_TITLE: Cancer Cell Intrinsic Interferon-I pathway Activation by Fractionated Radiation

STUDY_SECTION: CII

STUDY_SECTION_NAME: Cancer Immunopathology and Immunotherapy Study Section[CII]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Networking and Information Technology R&D (NITRD)

ORG_CITY: DALLAS

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: The proposed Biomedical Technology Development and Dissemination Center aims to consolidate and distribute imaging-based technology for the study of cellular signals. The Center will combine computer vision, light-sheet microscopy, and advanced imaging probes to visualize, control, and model molecular activities at the level of microns and seconds. The technology will be tested and refined in diverse biological systems and disseminated to the greater scientific community in partnerships with microscopy core facilities and established distribution platforms (Addgene, GitHub, ImageJ/Fiji, Applied Scientific Instrumentation).

PI_NAMEs: DANUSER, GAUDENZ  (contact);DEAN, KEVIN MICHAEL;HAHN, KLAUS M.

PROGRAM_OFFICER_NAME: YEH, ALVIN TIEN-WEI

PROJECT_TERMS: 3-Dimensional;Address;Adopted;analog;Automobile Driving;Behavior;Biochemical;Biological;Biological Models;Biological Process;biological systems;Biomedical Technology;Biosensor;career;cell behavior;cell motility;Cell Physiology;Cell Separation;Cell Signaling Process;Cells;Collaborations;Communities;Complex;computational pipelines;Computer Models;Computer software;Computer Vision Systems;Core Facility;cost effective;Data;Democracy;design;Discipline;Drug resistance;Ecosystem;Educational process of instructing;Environment;Etiology;Event;Feedback;field study;Fiji;Genetic;Goals;Home;Image;Image Analysis;imaging facilities;imaging modality;imaging platform;imaging probe;Imaging technology;Immune;immunological synapse;immunological synapse formation;improved;Infrastructure;Institution;instrumentation;Invaded;Kinetics;Lateral;Libraries;Light;live cell microscopy;Malignant Neoplasms;mechanotransduction;Metabolism;Methods;Microscope;Microscopy;migration;model organism;Modeling;Molecular;Molecular Analysis;molecular dynamics;molecular imaging;molecular modeling;Molecular Probes;multiplex detection;network architecture;neutrophil;open source library;Optics;optogenetics;Output;Pattern;Persons;Plug-in;Positioning Attribute;Postdoctoral Fellow;predictive modeling;Process;programs;Proteins;Proteomics;Reporter;Research Project Grants;Resolution;Sarcomeres;Scheme;Scientist;Series;Signal Transduction;Signal Transduction Pathway;spatiotemporal;Speed;Standardization;Statistical Methods;synaptic function;Synaptic plasticity;Technology;technology development;temporal measurement;Testing;Time;Time Series Analysis;Tissues;tool;Trainers Training;Training;United States;Update;user-friendly;Variant;Visualization;web site

PROJECT_TITLE: UTSW-UNC Center for Cell Signaling Analysis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-J(55)R]


ADMINISTERING_IC: AT

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Clinical Research;Complementary and Integrative Health;Dementia;Health Services;Neurodegenerative;Neurosciences;Patient Safety

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE Over the past 9 years, the National Institutes of Health (NIH) established a Health Care Systems Research Collaboratory (Collaboratory) worked to strengthen the national capacity to implement cost-effective large- scale research studies that engage health care delivery organizations as research partners.

PI_NAMEs: CURTIS, LESLEY H;HERNANDEZ, ADRIAN  (contact);WEINFURT, KEVIN P

PROGRAM_OFFICER_NAME: WEBER, WENDY J

PROJECT_TERMS: Achievement;Address;Belief;Caring;Clinical Research;Clinical Trials;Clinical Trials Data Monitoring Committees;clinically relevant;collaboratory;Communities;cost effective;Country;Data Sources;design;Dissemination and Implementation;Documentation;Elements;Ethics;experience;Face;Funding;Glean;Goals;Guidelines;health care delivery;Health system;Healthcare;Healthcare Systems;implementation efforts;improved;Infrastructure;Institutional Review Boards;Leadership;Learning;Light;member;Methods;Modeling;Modernization;Names;Opioid;Patients;Phase;Policies;Pragmatic clinical trial;pragmatic trial;pressure;Process;programs;Public Health;randomized trial;Research;Research Personnel;research study;Resources;Speed;System;systems research;Testing;Textbooks;tool;Training;Translating;trial design;United States National Institutes of Health;Vision;Work;working group

PROJECT_TITLE: NIH Health Care Systems Research Collaboratory-Coordinating Center (U24)


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_NAME: CHIMERNA THERAPEUTICS INC.

PHR: PROJECT NARRATIVE RNA is a major area of biomedical research and the basis of several novel core therapeutics being explored by diverse types of biotechnology companies. RNA is difficult to work with since it is highly susceptible to degradation, requires considerable time and effort for synthesis in the laboratory, difficult to purify, and difficult to chemically label. This proposal will result in the generation of two high-impact market-ready kits, one of which will allow researchers to create (1) large quantities of (2) highly stable and (3) highly purified RNA; and the other will allow researchers to readily impart diverse types of chemical tags to these RNAs.

PI_NAMEs: LITKE, JACOB  (contact)

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TERMS: Acceleration;Acetylgalactosamine;Affinity;Alkynes;aptamer;Area;Avidity;Binding;Biochemical Reaction;Biomedical Research;Biotechnology;Biotin;Cell Line;Cell Physiology;Cells;chemical synthesis;Chemicals;circular RNA;Companions;Complex;Data;Dextrans;Enzymes;Escherichia coli;Exonuclease;experimental study;Fluorescent Dyes;Gel;Generations;Genetic Transcription;Goals;Guide RNA;In Vitro;innovation;Label;Laboratories;Mammalian Cell;Manuals;Marketing;Messenger RNA;Methods;monomer;next generation;novel;Nucleotides;Phase;plasmid DNA;Plasmids;Porifera;Predisposition;Production;Protocols documentation;Reaction;Reproducibility;Research;Research Personnel;Resistance;RNA;RNA chemical synthesis;RNA Degradation;RNA purification;RNA Sequences;Sampling;Site;small molecule;Structure;System;Technology;Testing;Theophylline;Therapeutic;therapeutic RNA;Time;Tornadoes;Transcript;Transfection;Transfer RNA;Tube;Untranslated RNA;Work

PROJECT_TITLE: Next-generation RNA synthesis and labeling kits


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: HARARE

ORG_COUNTRY: ZIMBABWE

ORG_FIPS: ZI

ORG_NAME: CENTRE/SEXUAL HLTH/HIV AID RES/ZIMBABWE

PHR: Monitoring air quality is fundamental for understanding the biological and environmental vulnerabilities of a population in order to mitigate the effects of climate change and to ensure human health. Quantifying the impacts of ambient air pollution on pregnant women and neonates is a complex task, especially in countries across sub-Saharan Africa, where access to pollution exposure data is limited. In this proposed research project, we will utilize advanced data science solutions such as machine learning approaches to characterize pollution exposure and to understand its associations with adverse outcomes in maternal, newborn and child health.

PI_NAMEs: GOVINDASAMY, TAMARA ;MAKANGA, PRESTIGE TATENDA (contact)

PROGRAM_OFFICER_NAME: QUINN, ASHLINN KO

PROJECT_TERMS: Acceleration;adaptive intervention;Address;adverse birth outcomes;Adverse effects;adverse outcome;Africa;Africa South of the Sahara;African;Air;air monitoring;Air Pollution;ambient air pollution;Appointment;Biological;burden of illness;career;Child;Child Health;Childbirth;Climate;climate change;climate impact;climate-related health;Clinical;Cohort Studies;Collaborations;Communities;Complex;cost;Country;Coupled;Data;Data Analyses;Data Analytics;data repository;Data Science;Data Scientist;Derivation procedure;Deterioration;Development;doctoral student;Ecosystem;Ensure;Environmental Health;Environmental Pollution;Environmental Risk Factor;Epidemiology;experience;Exposure to;Food;Funding;Future;Generations;Goals;Health;health care availability;Health care facility;Heat Stress;Heat Waves;Human;improved;In Situ;Individual;Industrialization;Industry;Infant;innovation;Institution;interest;Intervention;Investigation;Joints;Knowledge;knowledge translation;Life;Link;Low Birth Weight Infant;Low income;Machine Learning;Maternal and Child Health;Maternal Health;Measurement;Measures;Michigan;Names;neonatal health;neonate;Outcome;Policies;pollutant;Pollution;Population;Population Growth;Postdoctoral Fellow;Poverty;Pre-Eclampsia;Predisposition;Pregnancy;Pregnant Women;Premature Birth;prenatal exposure;programs;promote resilience;prospective;Proxy;remote sensing;Research;Research Personnel;Research Project Grants;resilience;Resources;response;Risk;sensor;skills;SMART health;Socioeconomic Factors;Spontaneous abortion;statistical and machine learning;stillbirth;System;Techniques;Temperature;Testing;tool;Translating;Translations;United States National Institutes of Health;Universities;Urbanization;Validation;Vulnerable Populations;Washington;Water;Zimbabwe

PROJECT_TITLE: CHaracterizing Effects of Air Quality In Maternal, Newborn and Child Health: The CHEAQI-MNCH Research Project

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BTC-L(70)R]


ADMINISTERING_IC: EB

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_CITY: ATLANTA

ORG_DEPT: PEDIATRICS

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: The mission of the NIH-funded Atlanta Center for Microsystems Engineered POC Technologies (ACME POCT) is to assist and enable inventors from across the country who have developed microsystems-based POC technologies in defining their specific clinical needs, conducting clinical validation, and refining their technology, with the objective of accelerating the path to translation and clinical adoption. The ACME POCT uniquely leverages Atlanta’s nationally top-ranked clinical programs at Emory University’s hospitals and Children’s Healthcare of Atlanta, one of the nation’s largest pediatric hospital systems, as well the internationally acclaimed microsystems engineering expertise at Georgia Tech, which includes the Institute for Electronics and Nanotechnology, and other one-of-a-kind medical device prototyping, innovation, and testbed facilities. With the enhanced experience and expertise the ACME POCT gained serving as the Test Validation Core for the Rapid Acceleration of Diagnostics during the COVID-19 pandemic, the center is now especially well positioned to apply our lessons learned from RADx towards assisting any and all microsystems POC diagnostics for any and all clinical applications with a hands-on, pro-active approach.

PI_NAMEs: LAM, WILBUR A (contact);MARTIN, GREGORY S;VOGEL, ERIC M

PROGRAM_OFFICER_NAME: LASH, TIFFANI BAILEY

PROJECT_TERMS: Acceleration;Adoption;Advocacy;Biological Assay;Biomedical Engineering;Cells;Cellular Phone;Child health care;Clinical;Clinical and Translational Science Awards;clinical application;Clinical Research;Collaborations;commercialization;Communication;Communities;Companions;Country;Coupled;COVID-19;COVID-19 diagnostic;COVID-19 pandemic;Dedications;design;Development;Diagnostic;diagnostic development;diagnostic platform;Disease;Doctor of Philosophy;Ecosystem;Electronics;Engineering;Ensure;Equilibrium;Evaluation;experience;FDA Emergency Use Authorization;Fostering;Funding;General Population;Head;health equity;home test;Hospitals;Human;human subject;Infrastructure;innovation;insight;International;Laboratories;lateral flow assay;Leadership;Learning;manufacturability;manufacture;manufacturing scale-up;Medical Device;Medical Technology;Methods;microchip;Microfluidics;microsystems;Mission;mobile app development;mobile application;Nanotechnology;new pandemic;novel;operation;Patients;Pediatric Hospitals;pediatrician;Physicians;Point of Care Technology;portability;Positioning Attribute;Predisposition;programs;prototype;RADx;Readiness;Research;research clinical testing;Research Infrastructure;Role;Sampling;scale up;sensor;Side;Site;Societies;System;Technology;Technology Assessment;technology development;Testing;Training Activity;Translations;Underserved Population;United States National Institutes of Health;University Hospitals;usability;user centered design;Validation;Variant

PROJECT_TITLE: Atlanta Center for Microsystems Engineered Point-of-Care Technologies (ACME POCT)


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Eye Disease and Disorders of Vision;Neurosciences

ORG_DEPT: PHYSIOLOGY

PHR: PROJECT NARRATIVE The complexity of brain dynamics makes it difficult to understand how the brain controls the body in health and disease. This research project uses new methods for controlling neural circuits to investigate how variable activity patterns generate different motor behaviors. This will provide new insights into the neural basis of behavior and tools for manipulating brain dynamics with potential therapeutic applications.

PI_NAMEs: DAVIS, GREGORY PATRICK (contact)

PROGRAM_OFFICER_NAME: VAN'T VEER, ASHLEE VICTORIA

PROJECT_TERMS: Adolescent;Behavior;Behavioral;Biological Models;Brain;brain control;BRAIN initiative;Calcium;Cells;Cognitive;Correlation Studies;Data Set;Decision Making;Development;Disease;Electrophysiology (science);Eye;Eye Movements;eye velocity;Fishes;flexibility;gaze;Goals;Health;hindbrain;Image;improved;Individual;information processing;insight;Laboratory Finding;Laser Microscopy;Link;longitudinal dataset;Memory;Methods;Modality;model organism;monocular;Motor;motor behavior;motor control;Motor Neurons;Motor output;multimodality;neural;neural circuit;Neurons;neuroregulation;novel;oculomotor;oculomotor behavior;Optics;optogenetics;Output;Pattern;Phase;Photic Stimulation;Population;Positioning Attribute;Research;Research Project Grants;Resolution;Resources;response;Role;sample fixation;Short-Term Memory;Statistical Data Interpretation;System;Techniques;Testing;Therapeutic;Time;tool;two-photon;Variant;Vertebrates;Visual;visual motor;Work;Zebrafish

PROJECT_TITLE: The development of multimodal dynamics in a short-term memory system


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Coronaviruses;Coronaviruses Diagnostics and Prognostics;Emerging Infectious Diseases;Infectious Diseases

PI_NAMEs: LAM, WILBUR A (contact)

PROJECT_TERMS: Acceleration;Adoption;Authorization documentation;Beds;biobank;Biomedical Engineering;Cellular Phone;Charge;Child health care;Clinical;clinical application;clinical infrastructure;clinical practice;Clinical Research;Collaborations;commercialization;Communication;Communities;Companions;Complex;Consultations;Country;Coupled;COVID-19;COVID-19 diagnostic;COVID-19 pandemic;Data;Dedications;design;Development;Diagnostic;diagnostic development;diagnostic platform;diagnostic technologies;Disease;Doctor of Philosophy;Ecosystem;Electronics;Engineering;Ensure;Equilibrium;Evaluation;experience;Fostering;Funding;Head;health equity;Healthcare;Home;Hospitals;Human;implementation design;improved;Infrastructure;innovation;Institution;International;Knowledge;Laboratories;Leadership;manufacture;manufacturing scale-up;Medical;Medical Technology;meetings;microchip;Microfluidics;microsystems;Mission;mobile application;Monkeypox;Nanotechnology;Nature;Needs Assessment;new pandemic;novel;organizational structure;Patients;Pediatric Hospitals;pediatrician;Point of Care Technology;portability;Positioning Attribute;pre-clinical;Process;programs;Protocols documentation;prototype;Public Health;RADx;Readiness;response;Role;sensor;Services;Side;Site;smartphone application;Societies;Structure;Swab;System;Technology;Technology Assessment;Testing;Translating;translational diagnostics;Translations;Underserved Population;United States National Institutes of Health;usability;user centered design;Validation;validation studies

PROJECT_TITLE: Administrative Core


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Neurosciences;Substance Misuse

ORG_CITY: MEMPHIS

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF MEMPHIS

ORG_STATE: TN

PHR: Project Narrative Negative consequences of substance use are often underestimated because they occur later in time. However, little is known about how the brain processes the threat of delayed punishment during decision-making. This project will investigate the role of two understudied neuronal circuits in regulating sensitivity to both delayed and immediate punishment, which may enable novel neurobiological treatments to improve decision-making in substance use disorders.

PI_NAMEs: SIMON, NICHOLAS W (contact)

PROGRAM_OFFICER_NAME: MCCLURE-BEGLEY, TRISTAN DAVID

PROJECT_TERMS: addiction;Address;Affect;Agonist;Aversive Stimulus;Behavioral;Biological;Brain;Catecholamines;Cell Nucleus;cell type;Characteristics;Clozapine;Cognition;Costs and Benefits;Data;Decision Making;designer receptors exclusively activated by designer drugs;discount;discounting;Discrimination;Dopamine;Dopamine Receptor;dopaminergic neuron;Economics;Evaluation;experimental study;flexibility;genetic approach;Goals;Human;improved;Infusion procedures;insight;Intervention;Investigation;Legal;locus ceruleus structure;Mediating;Midbrain structure;neural;Neurobiology;neuromechanism;neuronal circuitry;Neurons;Neurotransmitters;noradrenergic;Norepinephrine;novel;Outcome;Oxides;Pain Threshold;Pharmaceutical Preparations;pharmacologic;Prevalence;Process;Punishment;Rattus;receptor;Receptor Activation;Regulation;Research;Rewards;Role;substance use;Substance Use Disorder;System;Time;Training;Tyrosine 3-Monooxygenase;Ventral Tegmental Area;Withdrawal

PROJECT_TITLE: Circuit-specific catecholamine regulation of sensitivity to delayed punishment

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


NIH_SPENDING_CATS: Behavioral and Social Science;Caregiving Research;Clinical Research;Dissemination and Implementation Research;Mental Health;Pediatric;Social Determinants of Health;Violence Against Women;Violence Research;Women's Health Research

ORG_NAME: UNIVERSITY OF HOUSTON

PHR: PROJECT NARRATIVE There is an urgent need to support African American mothers who have survived intimate partner violence (IPV) in order to buffer the mental health impact of trauma on their children. This project will leverage the sponsor’s R01 adapting the evidence-based Mediational Intervention for Sensitizing Caregivers (MISC) specifically for African American mothers to evaluate its suitability for adoption using mixed methodology and the Consolidated Framework for Implementation Research (CFIR). Barriers and facilitators to scale-up will be identified related to the intervention, outer setting, and inner setting for the project to make comprehensive recommendations for future adoption of MISC at scale and disseminate this evidence-based treatment to a priority population.

PI_NAMEs: ALLMAN, MADELEINE ELISE (contact)

PROGRAM_OFFICER_NAME: SIMS, BELINDA ENITA

PROJECT_TERMS: Adopted;Adoption;African American;African American Women;Age;Architecture;Area;Buffers;caregiver interventions;Caregivers;caregiving;Characteristics;Child;Child Mental Health;Child Rearing;Client;Clinical Psychology;Communication;community intervention;community organizations;community partners;community partnership;Consolidated Framework for Implementation Research;coordinated violence;County;Data;design;Doctor of Philosophy;Domestic Violence;Environment;Evaluation;evidence base;Evidence based treatment;experience;Exposure to;Faculty;Family;Feedback;Fellowship;Focus Groups;Funding Agency;Future;Genetic Transcription;Guidelines;High Prevalence;Housing;implementation facilitators;implementation intervention;implementation outcomes;implementation process;implementation science;implementation strategy;Incentives;Infrastructure;Intervention;Interview;intimate partner violence;Investments;Letters;Literature;Mental disorders;Mental Health;Methodology;Methods;Mothers;National Institute of Mental Health;Nature;opportunity cost;Outcome;parenting intervention;Patients;Perception;Policies;Population;Population Heterogeneity;Prevention;programs;protective factors;Psychopathology;psychosocial outcome;Public Health;Qualitative Research;Randomized, Controlled Trials;Recommendation;Regulation;Reporting;Research;Research Personnel;Research Proposals;Resources;Risk;scale up;SET Domain;social;Social Network;Source;stakeholder perspectives;Structure;Students;Surveys;Survivors;Training;Training Programs;Translational Research;Trauma;traumatic stress;treatment effect;Underserved Population;uptake;violence exposure;Woman;Workload

PROJECT_TITLE: Implementation and Scale-Up of a Caregiver Intervention for Mothers who have Survived Intimate Partner Violence: the Mediational Intervention for Sensitizing Caregivers

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F16-L(20)L]


NIH_SPENDING_CATS: Bioengineering

PROJECT_TERMS: Acceleration;Adoption;Child health care;Clinical;clinical application;Collaborations;Communities;Country;COVID-19 test;design;Development;Disease;Engineering;Funding;Hospitals;International;Laboratories;Microfabrication;microsystems;Mission;Monitor;Needs Assessment;Pediatric Hospitals;Point of Care Technology;Process;programs;prototype;RADx;Recommendation;Resources;Role;System;Technology;technology development;Testing;Translations;United States National Institutes of Health;Universities;usability;Validation;Work

PROJECT_TITLE: Technology Core


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Aging;Bioengineering;Brain Disorders;Cardiovascular;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Sleep Research

ORG_CITY: BOSTON

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

ORG_STATE: MA

PHR: PROJECT NARRATIVE: Data-Driven Sleep Biomarkers of Brain Health, Heart Health, and Mortality RELEVANCE: Sleep state signals encode critical biological information about brain and cardiovascular health. However, present approaches to polysomnography data (“sleep studies”) discard most of this information. This project will establish a comprehensive new dataset and new tools leveraging recent advances in data science to develop robust sleep-based biomarkers of brain and cardiovascular health and mortality.

PI_NAMEs: CLIFFORD, GARI DAVID;MIGNOT, EMMANUEL J;THOMAS, ROBERT JOSEPH;WESTOVER, MICHAEL BRANDON (contact)

PROGRAM_OFFICER_NAME: BAIZER, LAWRENCE

PROJECT_TERMS: Address;Adult;Age;Algorithms;Apnea;Arousal;Artificial Intelligence;artificial intelligence algorithm;Atrial Fibrillation;Biological;biological age;Biological Markers;Brain;Brain Diseases;brain health;Cardiac health;Cardiopulmonary;cardiovascular health;Cardiovascular system;Childhood;Clinical;Clinical Data;Code;cohort;Collaborations;Computational Science;Computerized Medical Record;Congestive Heart Failure;Coronary Arteriosclerosis;Coupling;Data;data portal;Data Science;Data Set;deep learning;Dementia;Detection;Development;Diagnosis;Diagnostic;diverse data;Electroencephalography;Electronic Health Record;Ensure;Epidemiology;Ethnic Origin;Ethnic Population;experience;Future;Goals;Graph;Health;Heart Diseases;Human;Hypertension;Hypoxia;Improve Access;indexing;Institution;Intracranial Hemorrhages;Ischemic Stroke;Libraries;life span;limb movement;Link;Machine Learning;machine learning method;Manuals;Measurable;Measures;Medical;Medicine;Morbidity - disease rate;mortality;Motor;Myocardial Infarction;novel;open data;open source;Outcome;Patients;pediatric patients;Performance;Periodicals;Persons;Phenotype;Physiology;Polysomnography;population based;Positioning Attribute;primary outcome;Publishing;Race;racial population;REM Sleep;Reporting;Research;respiratory;Sampling;Science;secondary outcome;sex;Signal Transduction;Sleep;Sleep Apnea Syndromes;Sleep Fragmentations;sleep physiology;Sleep Stages;social;Source;Staging;Stroke;Time;tool;Training;Underserved Population;Visual;Work

STUDY_SECTION: CHSB

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology B Study Section[CHSB]


ADMINISTERING_IC: DC

ED_INST_TYPE: GRADUATE SCHOOLS

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Dental, Oral, and Craniofacial Disease;Diabetes;Neurosciences;Nutrition

ORG_CITY: Los Angeles

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

ORG_STATE: CA

PHR: PROJECT NARRATIVE The palatable taste of sugar promotes excess calorie intake and has fueled epidemics of deadly diseases, like obesity and diabetes, in the United States. The proposed experiments aim to deepen our understanding about how sugars are sensed in the oral cavity and processed in brain reward circuits to reinforce consumption.

PI_NAMEs: SIMENTAL-RAMOS, ARACELY  (contact)

PROGRAM_OFFICER_NAME: SCHURMAN, JACLYN REBECCA

PROJECT_TERMS: Affect;Alpha-glucosidase;Amylases;Automobile Driving;Avidity;Behavior;Brain;Calories;Carbohydrates;Cells;Complex;Consummatory Behavior;Consumption;Data;Detection;detection of nutrient;detector;Diabetes Mellitus;Diet;dietary;Disaccharides;Disease;Dopamine;Energy Intake;Enzymes;Epidemic;experience;experimental study;Feeding behaviors;Fiber;Fructose;Genetic;Glucokinase;Glucose;glucose sensor;Glucose Transporter;glucosidase;glycemic control;Goals;hedonic;Hydrolysis;Ingestion;Intake;Investigation;knock-down;Knock-out;Knowledge;Laboratories;Learning;Ligands;Link;Maltose;Measures;Mediating;Mentors;mesolimbic system;Metabolic;Modeling;Monosaccharides;motivated behavior;Mus;novel;Obesity;Oral;Oral cavity;Pathway interactions;Peripheral;Photometry;Play;preference;Process;Publishing;rapid detection;receptor;recruit;Reflex action;Research;response;Rewards;Role;Salivary;Sampling;sensor;Signal Transduction;Site;Starch;Structure of beta Cell of islet;Sucrose;sugar;sweet receptor;sweet taste perception;Sweetening Agents;System;Taste Bud Cell;Taste Buds;Taste Perception;Taste preferences;taste transduction;Testing;testing access;Training;TRPM5 gene;United States;western diet;Work

PROJECT_TITLE: Alternative Orosensory Signals Contributing to Sugar Taste


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Colorectal Cancer;Digestive Diseases;Genetics;Human Genome;Orphan Drug;Radiation Oncology;Rare Diseases

PHR: Advanced rectal tumors are treated with combined chemotherapy and radiation therapy (chemoradiation) prior to surgery, but there is wide variation in the magnitude of tumor response. Optimizing non-surgical chemoradiation-based treatments could spare some patients the need to undergo a morbid surgery, but will require a detailed understanding of how chemoradiation causes evolution of tumor subpopulations as well as the development of unique approaches to therapeutically target these evolving subpopulations. This project will use cutting-edge techniques to dissect tumor responses to chemoradiation as well as an innovative approach to identify new treatment strategies for locally advanced rectal cancer.

PI_NAMEs: EYLER, CHRISTINE ELISSA (contact)

PROGRAM_OFFICER_NAME: BIAN, YANSONG

PROJECT_TERMS: Address;advanced disease;Architecture;Benchmarking;Cancer Model;Cancer Patient;career development;Cells;chemoradiation;chemotherapy;Chemotherapy and/or radiation;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Colostomy Procedure;Combination Drug Therapy;CRISPR/Cas technology;Cytotoxic Chemotherapy;Data;design;Development;Diagnosis;Disease;Drug Screening;drug sensitivity;Effectiveness;Epigenetic Process;epigenomics;Evaluation;Evolution;Excision;experience;Experimental Models;Foundations;Genetic;genome-wide;Genomics;Genotype;Goals;high-throughput drug screening;Human;Implant;improved;In complete remission;Infrastructure;innovation;Institution;Instruction;knowledge base;KRAS2 gene;Laboratories;Light;lymph nodes;Malignant Neoplasms;Mentors;Methods;Modeling;mutant;Mutation;Neoadjuvant Therapy;neoplastic cell;non-genetic;novel;novel therapeutic intervention;Operative Surgical Procedures;Organoids;Pathologic;patient derived xenograft model;patient subsets;Patients;Phenotype;Radiation therapy;radioresistant;Rectal Cancer;Rectal Neoplasms;Rectum;Research;Resistance;resistance mechanism;response;Sampling;screening;single-cell RNA sequencing;Specimen;standard care;Structure;subclonal heterogeneity;success;targeted treatment;Techniques;therapeutic target;therapy resistant;Thick;Time;TP53 gene;Training;Treatment outcome;treatment strategy;trend;tumor;tumor eradication;Tumor Volume;Variant;Xenograft Model

PROJECT_TITLE: Harnessing treatment-induced tumor evolution and collateral sensitivities using a human rectal cancer co-clinical platform

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


ED_INST_TYPE: UNIVERSITY-WIDE

ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: Project Narrative The proposed research will identify genes and pathways that underlie neurotoxin resistance and sequestration in animals. Results will improve our understanding of neurological disease arising from ion channel malfunction (“channelopathies”) and provide novel insight into effective drug design and delivery.

PI_NAMEs: TARVIN, REBECCA D. (contact)

PROGRAM_OFFICER_NAME: NIE, ZHONGZHEN

PROJECT_TERMS: Affect;Amphibia;Animals;Bacteria;Biological;Biology;Complex;Cystic Fibrosis;Cytochrome P450;Diabetes Mellitus;Disease;disease phenotype;Drosophila genus;Drug Delivery Systems;Drug Design;Drug resistance;epibatidine;Epilepsy;Excretory function;experimental study;feeding;fitness;gene interaction;Genes;Genetic;genome sequencing;Genotype;Goals;Human;improved;Ingestion;insight;Ion Channel;Ion Channel Protein;Link;Medicine;Metabolism;Migraine;Modeling;multi drug transporter;Mutation;Myotonia;Nervous System;Nervous System Disorder;Nervous System Physiology;Neurotoxins;Newts;Nicotine;novel;Organism;Pathway interactions;Pharmaceutical Preparations;Pharmacologic Substance;Pharmacology;Phenotype;Play;Poison;Production;Proteins;Rana;Research;Research Personnel;Resistance;Role;Skin Tissue;System;Tetrodotoxin;Tissues;toad;Toxin;toxin metabolism;trait;transcriptome sequencing;whole genome

PROJECT_TITLE: Evolutionary genetics of adaptation to toxins in animals

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MGG-C(55)R]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Clinical Research;Epilepsy;Neurodegenerative;Neurosciences;Parkinson's Disease;Rehabilitation

ORG_DEPT: NEUROLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Project Narrative This research will provide a theoretically-motivated account of the cortical mechanisms behind sensorimotor con- trol in the typical speech of patients with Epilepsy undergoing extra-operative clinical monitoring. The project will also account for the subcortical contribution to sensorimotor control in individuals with dysarthria and Parkinson's disease who have undergone neurosurgical intervention. Results will inform the development of novel treatment approaches that tap into sensorimotor control mechanisms to improve speech outcomes in Parkinson's disease.

PI_NAMEs: KABAKOFF, HEATHER M (contact)

PROJECT_TERMS: Acoustics;Affect;alternative treatment;Aphasia;Apraxia;Articulation;Articulators;auditory feedback;Basal Ganglia;behavior measurement;Behavioral;behavioral response;Bilateral;Brain;Clinical;clinical care;Communication;Compensation;Complex;Data;Deep Brain Stimulation;design;Development;direct application;Dorsal;Dysarthria;Electrocorticogram;Electrophysiology (science);Epilepsy;Feedback;Frequencies;Future;Goals;Hospital Departments;Image;Impaired cognition;Impairment;improved;Incidence;Individual;Intervention;Investigation;Laryngeal muscle structure;Larynx;Learning;Link;Maps;Measurement;Modeling;Monitor;Motor;motor control;Motor Cortex;motor disorder;motor impairment;neural;neuroimaging;Neurology;neuromechanism;neuroregulation;neurosurgery;novel;Oral;Outcome;Output;Parkinson Disease;Pathway interactions;Patients;Perioperative;Phonation;Population;prevent;Process;Production;programs;Quality of life;recruit;Rehabilitation therapy;remediation;Reporting;Research;response;Role;sensorimotor control mechanism;social;Speech;Speech Development;Speech Disorders;Structure;Structure of subthalamic nucleus;Stuttering;Testing;theories;therapeutic development;Time;Vocation

PROJECT_TITLE: Cortical and subcortical underpinnings of typical and dysarthric speech - Resubmission - 1


NIH_SPENDING_CATS: Neurosciences

ORG_DEPT: OTOLARYNGOLOGY

PHR: Project Narrative  T-stellate cells have sharp frequency tuning and selective responses to fluctuations in sound amplitude and are implicated in the first processing of auditory signals relating to speech. T-stellate cells in the anteroventral cochlear nucleus provide one of the largest sources of input to the inferior colliculus (IC), however, how T-stellate input to the IC contributes to speech processing remains largely unknown. The proposed research will determine how T-stellate cells influence IC signal processing at a cellular and circuit level and will provide a crucial advance towards understanding how the ascending auditory pathway processes signals pertaining to vocalization and speech cues.

PI_NAMEs: HERRERA, YOANI NATALIE (contact)

PROJECT_TERMS: Acoustic Nerve;Address;Agonist;Auditory;auditory pathway;auditory processing;Auditory system;Brain;Brain Stem;Cell Nucleus;cell type;Cells;Cochlear Implants;Cochlear nucleus;Code;Communication;Cueing for speech;Cues;Data;Dementia;Dendrites;Electrophysiology (science);Equilibrium;Evoked Potentials;excitatory neuron;Excitatory Postsynaptic Potentials;Exhibits;experimental study;Fluorescence;Frequencies;Genetic;genetic approach;Glutamates;Goals;Health;Hearing Aids;hearing impairment;Human;Impaired cognition;In Vitro;in vivo;Individual;Inferior Colliculus;inhibitory neuron;insight;Intervention;Kinetics;Knowledge;Label;Light;Link;Maps;Mental Depression;Midbrain structure;molecular marker;neural circuit;neuronal excitability;Neurons;neuropeptide Y;novel;Opsin;optogenetics;patch clamp;Pathway interactions;pharmacologic;Pharmacology;Play;Population;Prevalence;Process;receptor;recruit;Research;response;Role;Shapes;signal processing;Signal Transduction;Silicon;Slice;Social isolation;sound;sound frequency;Source;Speech;speech processing;stellate cell;Stimulus;Synapses;synaptic depression;System;Testing;Vasoactive Intestinal Peptide;vocalization;Whole-Cell Recordings

PROJECT_TITLE: Influence of T-Stellate Cell Input on Sound Processing in the Inferior Colliculus


NIH_SPENDING_CATS: Bioengineering;Clinical Research

PI_NAMEs: MARTIN, GREGORY S (contact)

PROJECT_TERMS: Acceleration;Address;Adoption;Child health care;Clinical;clinical application;Collaborations;Communities;Country;COVID-19 diagnostic;COVID-19 pandemic;Data Collection;data management;design;Development;Devices;Diagnostic;Disease;Ecosystem;Education;Electronics;Engineering;Environment;Ethics;experience;Fostering;Funding;Health;Health system;Home;Hospitals;Human;human subject;Industry;Infrastructure;innovation;instrument;International;Laboratories;manufacturing scale-up;Medical Device;Medical Technology;microsystems;Mission;Nanotechnology;Needs Assessment;new pandemic;patient oriented;Pediatric Hospitals;Performance;Point of Care Technology;Positioning Attribute;programs;prototype;RADx;research clinical testing;Research Design;Research Personnel;Risk;Role;Services;Statistical Data Interpretation;System;Technology;Testing;Translations;United States National Institutes of Health;Universities;University Hospitals;usability;Validation;validation studies

PROJECT_TITLE: Clinical Core


NIH_SPENDING_CATS: Clinical Research;Data Science;Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: EUGENE

ORG_NAME: UNIVERSITY OF OREGON

ORG_STATE: OR

PHR: PROJECT NARRATIVE The hippocampus plays a key role not only in encoding new episodic memories, but in separating neural representations for highly similar—and potentially interfering—memories. The proposed research will leverage Natural Language Processing algorithms and advanced computational and neuroimaging methods to test whether separation of hippocampal representations predicts distortions in how events are actually remembered (i.e., the content of episodic memories). The project will lead to fundamental new insight into how the hippocampus resolves interference between similar memories and will establish exciting new approaches for investigating these mechanisms.

PI_NAMEs: BABU, ANISHA  (contact)

PROJECT_TITLE: Understanding Changes in Hippocampal Representations by Measuring Memories with Natural Language Processing


NIH_SPENDING_CATS: Autism;Brain Disorders;Clinical Research;Dissemination and Implementation Research;Health Services;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric

ORG_CITY: LA JOLLA

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE  Identifying the mechanisms of organizational implementation strategies that positively impacted implementation outcomes and child outcomes is crucial for creating targeted implementation interventions to improve the health outcomes of autistic children. Leveraging data from the TEAMS (Translating Evidence- based Interventions for Autism: A Multi-Level Implementation Strategy) Hybrid Type III trials, the proposed project will 1) identify individual climate embedding mechanisms associated with implementation (provider) and clinical (child) outcomes, 2) utilize quantitative methods to examine whether the individual climate embedding mechanisms identified in Aim 1 mediate the effects of an organization-level implementation strategy on implementation and clinical outcomes, and 3) Use qualitative and mixed methods to complement and expand quantitative findings on additional climate embedding mechanisms and explain how individual mechanisms facilitated implementation of autism EBPs. The present study represents an important step in further understanding mechanisms of organizational implementation strategies for autism EBPs in publicly funded settings.

PI_NAMEs: RANGEL, ELIZABETH  (contact)

PROJECT_TERMS: autism spectrum disorder;autistic children;career;Caring;Centers for Disease Control and Prevention (U.S.);Child;child mental health service;Climate;Clinical;Community Services;community setting;Complement;Data;Development;Education;Educational process of instructing;effective intervention;effectiveness testing;Evidence based intervention;Evidence based practice;Exploration, Preparation, Implementation, and Sustainment;Fostering;Funding;Goals;Health;Health Services Research;Hybrids;implementation determinants;implementation facilitation;implementation intervention;implementation outcomes;implementation science;implementation strategy;improved;Individual;Intervention;Interview;Investigational Therapies;Leadership;Link;Literature;Measures;Mediating;medical specialties;meetings;Mental Health;Mentors;Methods;Modeling;National Institute of Mental Health;National Research Service Awards;Organizational Change;organizational climate;Organizational Culture;Outcome;Parents;Perception;programs;prospective;Provider;Randomized, Controlled Trials;Reporting;Research;Role;routine care;school district;Schools;Scientist;Service setting;Services;Source;Strategic Planning;Structure;System;telephone coaching;Testing;Time;tool;Training;training opportunity;Translating;United States

PROJECT_TITLE: Identifying Effective Organizational Climate Embedding Mechanisms for Autism Interventions

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F16-H(20)L]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: TAMPA

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF SOUTH FLORIDA

ORG_STATE: FL

PHR: Enhancer RNAs (eRNAs) are a new class of noncoding RNAs that play important roles in chromatin interactions and regulation of gene expression, but their significance during stroke is not known. In this project, we investigate the role of a recently identified stroke-induced eRNA in the adult cerebral cortex in order to understand its involvement in post-stroke brain damage. This work may help identify novel therapeutic targets against ischemic stroke.

PI_NAMEs: DHARAP, ASHUTOSH  (contact)

PROGRAM_OFFICER_NAME: BOSETTI, FRANCESCA

PROJECT_TERMS: Acetylation;Acute;Adult;Affect;Binding;Binding Sites;Biological Assay;blood-brain barrier disruption;Brain;Brain Injuries;Budgets;cdc Genes;Cell Adhesion;cell cortex;Cell Cycle Arrest;Cell Death;cell type;Cerebral cortex;Cerebral Ischemia;ChIP-seq;Chromatin;crosslink;Cyclic AMP;Data;Development;Disease;DNA;DNA Polymerase II;endoplasmic reticulum stress;Enhancers;Estrogens;experimental study;Extracellular Matrix;Female;Fluorescent in Situ Hybridization;Functional disorder;Future;Gene Expression;Gene Expression Regulation;Gene Proteins;gene repression;Genes;Genetic Enhancer Element;Genetic Transcription;genome-wide;genomic locus;Genomics;Histones;Immunoprecipitation;improved;in vivo;Infarction;Investigation;Ischemia;Ischemic Stroke;knock-down;loss of function;Lysine;Macrophage;male;Maps;Mediating;Methods;Middle Cerebral Artery Occlusion;Molecular;Molecular Target;Mus;Neurologic;Neurons;new therapeutic target;novel;Outcome;Pathologic;Pathway interactions;Phase;Phenotype;Physiological;Play;post stroke;programs;Proteins;Reperfusion Therapy;Reporter;Reporting;response;RNA;Role;Running;Sensorimotor functions;sex;sex as a biological variable;Sex Differences;Signal Transduction;Stimulus;Stroke;stroke outcome;Structure;Testing;Therapeutic;Time;TP53 gene;Transcript;transcription factor;Transcriptional Activation;transcriptome sequencing;Translations;Ubiquitination;Untranslated RNA;virtual;Western Blotting;Work

PROJECT_TITLE: Functional characterization of an enhancer RNA in cerebral ischemia

STUDY_SECTION: BINP

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Cerebral Palsy;Clinical Research;Clinical Trials and Supportive Activities;Down Syndrome;Intellectual and Developmental Disabilities (IDD);Lung;Neurosciences;Palliative Care;Patient Safety;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Sleep Research

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PI_NAMEs: O'BRIEN, LOUISE M. (contact);ZOPF, DAVID ADAM

PROGRAM_OFFICER_NAME: BROWN, MARISHKA

PROJECT_TERMS: Address;Adherence;adherence rate;aged;airway obstruction;Anatomy;Anoxic Encephalopathy;Apnea;arm;Arousal;Asphyxia;Bypass;Caregivers;Caring;Cerebral Palsy;Child;Childhood;Clinical;Clinical assessments;Clinical Trials;cohort;Controlled Clinical Trials;Data;desensitization;design;Device Approval;Devices;Diffuse;Discipline of Nursing;Down's Syndrome;effective therapy;Effectiveness;Engineering;Evaluation;Failure;Family;family burden;Goals;Grant;Head and Neck Surgery;Healthcare;High Prevalence;Home;improved;Incidence;inclusion criteria;indexing;Intervention;Literature;Maintenance;Masks;Medical Care Costs;Medicine;meetings;Molecular Abnormality;Morbidity - disease rate;mortality;multidisciplinary;Muscle;Muscle hypotonia;Nasopharynx;Neuromuscular Diseases;novel;Obstruction;Obstructive Sleep Apnea;Operative Surgical Procedures;Otolaryngology;Outcome;Oxygen;Palliative Care;Patients;Pattern;pediatric patients;Phase;Physiological;Polysomnography;Population;positive airway pressure;Preparation;Prevalence;Procedures;Protocol Compliance;Protocols documentation;Quality of life;Questionnaires;Randomized;Recurrence;Residual state;Resources;Risk;Safety;safety assessment;Severities;Site;Sleep;Sleep Apnea Syndromes;sleep quality;standard of care;Stents;Symptoms;Testing;Tracheostomy procedure;Translations;treatment duration;Treatment Efficacy;Vomiting;Waiting Lists

PROJECT_TITLE: Self-Supporting Nasopharyngeal Airway (ssNPA) Treating Upper Airway Obstruction in Hypotonia

STUDY_SECTION: SSPT

STUDY_SECTION_NAME: NHLBI Single-Site and Pilot Clinical Trials Study Section[SSPT(JA)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: Project Narrative. Adaptive functioning in all animals, including humans, requires a careful balance between recognition and pursuit of potential rewards (food, shelter, and social interaction, among others) and detection and avoidance of potential threats (theft, natural disasters, and interpersonal rejection, for instance). Many psychiatric diseases involve impairments in one or both of these processes, symptoms which significantly impair functioning and cause considerable distress. The present work will investigate the neural basis of alterations in reward and threat processing following chronic stress in mice, with the goal of understanding and ameliorating the changes in brain circuitry that lead to impairments in reward and threat processing.

PI_NAMEs: GREEN, ISOBEL WOUK (contact)

PROJECT_TERMS: Affect;Anhedonia;Animals;Anxiety Disorders;approach behavior;approach/avoidance behavior;Automobile Driving;avoidance behavior;base;Behavior;Behavioral;behavioral response;biological adaptation to stress;brain circuitry;Chronic;Chronic stress;cohort;conditioning;Conflict (Psychology);Corpus striatum structure;Data;Detection;Distress;Dopamine;dopaminergic neuron;Elements;Equilibrium;Food;Goals;Grain;Human;Impairment;Individual;Investigation;Laboratories;Learning;Life;Literature;Machine Learning;Maps;Mediating;Mental disorders;Midbrain structure;Mood Disorders;Motivation;Mus;Natural Disasters;neural;neurobehavioral;neurobiological mechanism;Neurobiology;novel;optogenetics;Play;Population;Post-Traumatic Stress Disorders;preference;Process;Psychotic Disorders;Resolution;response;Rewards;Rodent;Role;Shelter facility;Signal Transduction;Social Interaction;Stress;stressor;Sucrose;Symptoms;Tail;Techniques;Testing;Theft;tool;Variant;Ventral Striatum;Work

PROJECT_TITLE: Investigating the impact of chronic stress on distinct axes of dopamine signaling

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F02A-W(20)]


PI_NAMEs: KU, DAVID N (contact)

PROJECT_TERMS: Acceleration;Adoption;Automobile Driving;Awareness;Child health care;Clinical;Communities;Country;Data;design;Development;Devices;Diagnostic;Disease;Ecosystem;Education and Outreach;Educational Curriculum;Educational workshop;Engineering;Ensure;Evaluation;Funding;Goals;Hospitals;Human Resources;Information Dissemination;insight;Institution;Intake;International;Lead;microsystems;Mission;Needs Assessment;Patients;Pediatric Hospitals;Point of Care Technology;Policy Maker;programs;Publications;Resources;symposium;System;Technology;Training;Training Activity;Translations;United States National Institutes of Health;Universities;Validation;webinar

PROJECT_TITLE: Dissemination Core


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_NAME: BOSTON MEDICAL CENTER

PHR: Project Narrative The proposed conference series includes both a 2-day annual meeting delivered in an innovative hybrid format and a 1-day midyear summit focused on skill-building, networking, and strategy development. These convenings will foster ongoing innovation, communication, and collaboration among organizations and individuals conducting academic detailing in the United States and internationally. Conference attendees and speakers will share best practices and challenges in the field that will lead to the strengthening of academic detailing practice and opportunities for innovative new interventions and research.

PI_NAMEs: FISCHER, MICHAEL A. (contact)

PROGRAM_OFFICER_NAME: ZHANG, XINZHI

PROJECT_TITLE: NaRCAD's International Conference Series: An Innovative Model to Advance the Field of Clinical Outreach Education

STUDY_SECTION: HEOR

STUDY_SECTION_NAME: Healthcare Effectiveness and Outcomes Research[HEOR]


ORG_CITY: DUARTE

ORG_NAME: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE

PHR: PROJECT NARRATIVE The overall goal of this Glioblastoma Therapeutics Network U19 application is to develop superior treatments for patients with glioblastoma, the most common and aggressive primary brain tumor in adults. Effective treatments for glioblastoma remain elusive, and patients are rarely cured with standard therapies. The proposed research projects will all evaluate novel therapeutic agents in phase 1 clinical trials, and, if successful, have the potential to transform the treatment of patients with glioblastoma.

PI_NAMEs: BADIE, BEHNAM ;PORTNOW, JANA  (contact)

PROGRAM_OFFICER_NAME: FORRY, SUZANNE L

PROJECT_TERMS: Address;Adult;Adult Glioblastoma;Alabama;Anti-CD47;Antibody Therapy;Basic Science;Bioinformatics;Biological;Biological Products;blood-brain barrier crossing;blood-brain barrier penetration;Cities;Clinical;Clinical Research;clinical trial enrollment;Clinical Trials;Collaborations;Correlative Study;Cyclic GMP;Data;design;Development;drug development;drug testing;Educational process of instructing;effective therapy;Engineering;exome;exome sequencing;experience;Genomics;Glioblastoma;Goals;Herpesviridae;Heterogeneity;immune modulating agents;immunopharmacology;Immunosuppression;Immunotherapy;improved;inhibitor;innovation;Institution;interest;Laboratories;Laboratory Scientists;Length;manufacture;Methods;Microdialysis;Molecular;Molecular Profiling;Monoclonal Antibodies;neoplastic cell;New Agents;next generation;novel;novel therapeutics;Oncolytic;Oncolytic viruses;Pathway interactions;Patient Selection;Patients;Penetration;Perioperative;Pharmaceutical Preparations;Phase;Phase I Clinical Trials;Population;preclinical development;preclinical study;Primary Brain Neoplasms;Research;Research Activity;Research Institute;Research Project Grants;Resource Sharing;Resources;Services;single cell sequencing;Site;small molecule;small molecule inhibitor;Stromal Cells;Techniques;Testing;Therapeutic;Therapeutic Agents;Time;tool;transcriptome;transcriptome sequencing;Translating;translational genomics;Translational Research;tumor heterogeneity;tumor microenvironment;Universities;Work

PROJECT_TITLE: Development of Small Molecule Inhibitors and Biologic Agents for Treatment of Glioblastoma Using Intracerebral Microdialysis and Signatures of Vulnerability


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Neurosciences;Orphan Drug;Rare Diseases

PI_NAMEs: PORTNOW, JANA  (contact)

PROJECT_TERMS: Alabama;Basic Science;Biological Products;Biometry;Brain Neoplasms;Cities;clinical development;Clinical Research;Clinical Trials;Collaborations;Data;data integration;data management;data quality;design;Development;effective therapy;electronic data;Ensure;first-in-human;Funding;Glioblastoma;Goals;human subject protection;improved outcome;Infrastructure;Institution;Leadership;Legal patent;meetings;member;Microdialysis;Modeling;novel;novel therapeutics;Occupational activity of managing finances;Patient-Focused Outcomes;Patients;Performance;Pilot Projects;Policies;Preparation;programs;Progress Reports;Publications;quality assurance;Reporting;Research;Research Activity;Research Institute;Research Personnel;Research Project Grants;Resource Sharing;Resources;small molecule inhibitor;Statistical Data Interpretation;Structure;Technology Transfer;Testing;Therapeutic;translational genomics;Translational Research;Translations;Travel;trial design;United States National Institutes of Health;Universities;Visualization;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Mental Health;Neurodegenerative;Neurosciences

ORG_NAME: COLUMBIA UNIV NEW YORK MORNINGSIDE

PHR: PROJECT NARRATIVE The motor behaviors we engage in constitute a fundamental element of human experience, and yet, it is poorly understood how these behaviors interact with our ability to remember novel, non-motor information. My proposal will bridge the fields of motor learning and episodic memory by revealing how the well-learned motor routines we follow as part of everyday life (e.g., commuting to work) facilitate memory for temporally-coincident novel experiences, while also shedding light on the neural mechanisms that underlie these interactions. In the long term, this work will strengthen theories of how distinct memory systems interact in behavior and the brain, which may advance knowledge of how episodic memory deficits arise in populations with motor impairments (e.g., Parkinson’s), and how they can be mitigated in those where motor function is spared (e.g., Alzheimer’s).

PI_NAMEs: GASSER, CAMILLE  (contact)

PROGRAM_OFFICER_NAME: PINARD, COURTNEY ROSE

PROJECT_TITLE: Interactions between motor learning and episodic memory


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Lewy Body Dementia;Neurodegenerative;Neurosciences;Parkinson's Disease

ORG_CITY: ARLINGTON

ORG_NAME: NEURODEX INC

PHR: PROJECT NARRATIVE Up to 30% of patients with dementia have aggregates of alpha-synuclein called Lewy bodies in the brain, and when these are present, patients should not receive antipsychotic drugs to treat common symptoms because these drugs can cause rapid worsening of the disease and early death. Current methods to determine which patients have these aggregates are difficult, expensive, and rarely used in patients without clear evidence of specific diseases, resulting in more than two-thirds of these patients going undiagnosed. This project is designed to develop and validate a new blood-based test to determine whether patients with dementia have these aggregates, with the goal of informing patient care to prevent inappropriate prescription of antipsychotic drugs.

PI_NAMEs: EITAN, EREZ  (contact)

PROGRAM_OFFICER_NAME: AUBRECHT, TARYN GRACE

PROJECT_TERMS: Address;Adverse effects;Age;alpha synuclein;Alzheimer's Disease;American;Amyloid beta-Protein;Antipsychotic Agents;Autopsy;Biological Assay;Biological Markers;biomarker discovery;Blood;Blood specimen;Blood Tests;Blood Vessels;Brain;brain cell;Brain region;cell type;Cells;Cessation of life;Classification;CLIA certified;Clinical;Clinical Trials;commercialization;common symptom;Coronavirus;Data;Dementia;Dementia with Lewy Bodies;design;Detection;Development;Diagnosis;Diagnostic;diagnostic assay;diagnostic value;Differential Diagnosis;Disease;Drowsiness;drug development;extracellular vesicles;Goals;high risk;Impaired cognition;improved;Individual;Lewy Bodies;Lewy body pathology;Life;Measurement;Measures;Medical;Methods;Microglia;Multiple System Atrophy;Nerve Degeneration;Neurodegenerative Disorders;Neuroleptic Malignant Syndrome;Neurons;Noise;novel;Oligodendroglia;Parkinson Disease;Parkinsonian Disorders;Pathology;Patient Care;patient stratification;Patients;Performance;Pharmaceutical Preparations;Phase;Physicians;Plasma;prevent;Procedures;Prognosis;protein TDP-43;Qualifying;Reproducibility;Sampling;Signal Transduction;Small Business Innovation Research Grant;Specificity;Stratification;success;Surface;Symptoms;synuclein;synucleinopathy;tau Proteins;Testing;treatment planning;Validation;Vascular Dementia;Work

PROJECT_TITLE: Development of a Blood-based Test for Identifying Synucleinopathy in Patients with Dementia


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Services;Lung;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Orphan Drug;Pediatric;Precision Medicine;Prevention;Pulmonary Hypertension;Rare Diseases

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: PROJECT NARRATIVE Pulmonary arterial hypertension (PAH) is a rapidly progressive fatal disease for which there are few therapeutic options. Understanding how to predict clinical responses to available therapeutics would be a significant clinical advance in treating this disease by permitting tailored, targeted and effective first line therapies. Our continued studies seek to develop and validate a decision support tool for predicting survival in Adult and Pediatric PAH, which will allow the scientific community and patients a means to choose appropriate specific therapies based on individual risks and patient choices in order to improve survival and quality of life for our patients.

PI_NAMEs: BENZA, RAYMOND LOUIS (contact)

PROGRAM_OFFICER_NAME: XIAO, LEI

PROJECT_TERMS: Academia;Adult;Bayesian Modeling;Behavior;Behavioral;behavioral outcome;Benchmarking;biobank;Biological Markers;Biomedical Engineering;Cardiovascular Pathology;Caring;Child;Childhood;Clinical;Clinical Decision Support Systems;clinical practice;clinical predictors;Clinical Trials;Clinical Trials Design;cohort;Communities;Complex;computer human interaction;computer science;Consensus;cost;cost effectiveness;Data;Data Element;data harmonization;data mining;data registry;Data Set;Databases;Derivation procedure;Development;diagnostic tool;Discrimination;Disease;Disease Progression;Feedback;Fingerprint;Foundations;Future;Generations;genomic data;Genomics;Goals;hypertension treatment;Image;Image Enhancement;improved;Individual;individualized medicine;Industry;Intention;Intervention;intervention cost;Machine Learning;machine learning method;medical specialties;Modeling;Modernization;Monitor;multidisciplinary;Nature;neglect;next generation;novel marker;Outcome;outcome prediction;Palliative Care;Pathway interactions;Patient risk;patient subsets;Patient-Focused Outcomes;Patients;Pattern;Pediatrics;Performance;Pharmacologic Substance;Phenotype;Physicians;Population;prediction algorithm;Prognosis;prognostic;prospective;Provider;provider adoption;provider behavior;Publications;pulmonary arterial hypertension;Pulmonary Heart Disease;Pulmonary Hypertension;Quality of life;randomized, clinical trials;Registries;Resources;response;Risk;Risk Assessment;risk prediction;risk stratification;Sensitivity and Specificity;Standardization;Statistical Models;support tools;survival prediction;Testing;Therapeutic;tool;Training;Treatment Effectiveness;treatment pattern;treatment response;treatment stratification;Update;uptake;Validation;Vascular remodeling;Work

PROJECT_TITLE: PHORA-Pulmonary Hypertension Outcome Risk Assessment

STUDY_SECTION: CIDH

STUDY_SECTION_NAME: Clinical Informatics and Digital Health Study Section[CIDH]


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Orphan Drug;Rare Diseases

PI_NAMEs: SYNOLD, TIMOTHY W (contact)

PROJECT_TERMS: Address;Analytical Chemistry;analytical method;Bioinformatics;Biological Assay;Biological Markers;Biological Products;Biological Response Modifier Therapy;Blood - brain barrier anatomy;Brain;Central Nervous System;Central Nervous System Neoplasms;Cerebrospinal Fluid;chemokine;City of Hope Comprehensive Cancer Center;Clinical;clinical development;Clinical Trials;Collaborations;Complex;Comprehensive Cancer Center;Consultations;Correlative Study;cytokine;Data Analyses;design;Development;Drug Delivery Systems;Drug Kinetics;effective therapy;Elements;Enzyme-Linked Immunosorbent Assay;experience;Experimental Designs;Future;Glioblastoma;Goals;High Pressure Liquid Chromatography;Human Resources;Immunoassay;Immunochemistry;Immunologics;immunopharmacology;Inductively Coupled Plasma Mass Spectrometry;instrumentation;Intercellular Fluid;interstitial;Investigation;Knowledge;Ligands;Liquid substance;method development;Microdialysis;Molecular Profiling;novel;novel therapeutic intervention;novel therapeutics;participant enrollment;Patients;Pharmaceutical Preparations;pharmacodynamic model;Pharmacodynamics;pharmacokinetics and pharmacodynamics;Pharmacology Study;Plasma;preclinical development;programs;Protein Secretion;Protocols documentation;Qualifying;Research;Research Design;Research Personnel;Research Project Grants;response;Sampling;Serum;Services;small molecule;small molecule inhibitor;Techniques;Therapeutic;therapeutic development;Time;Training;Translational Research;tumor;Work;Writing

PROJECT_TITLE: Analytical Immunopharmacology


ORG_CITY: PITTSBURGH

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE Stress response mechanisms play a dual role in organism health- they are required for tissue homeostasis and also for minimizing damage during toxic conditions. Intimate molecular knowledge of these mechanisms will thus inform clinical approaches to prolong tissue function under pathobiological conditions. Consistent with the mission of the NIGMS, the research described herein aims to gain such mechanistic understanding and will have broadly relevance to many pathologies from neurodegeneration to cancer.

PI_NAMEs: VASUDEVAN, DEEPIKA  (contact)

PROGRAM_OFFICER_NAME: RIGAS, MARC

PROJECT_TERMS: Adipocytes;Biological;biological adaptation to stress;cell type;Cells;Cellular biology;Cellular Stress;Clinical;combat;Data;Dedications;Defect;Diabetes Mellitus;Disease;Drosophila genus;egg;Egg Yolk Proteins;Fatty acid glycerol esters;Genetic;Health;Hepatocyte;Homeostasis;hormonal signals;improved;insight;Islet Cell;Knowledge;loss of function;Malignant Neoplasms;Mediating;Metabolic;Mission;Molecular;Molecular Biology;mRNA Translation;mutant;National Institute of General Medical Sciences;Nerve Degeneration;Neurons;neuroregulation;nutrient deprivation;oocyte maturation;Oogenesis;Organism;Ovary;Pancreas;Pathology;Pathway interactions;Peripheral;Phenotype;Photoreceptors;Play;protein degradation;Regulation;Research;response;Role;Secretory Cell;sensor;steroid hormone;Stress;Stress Response Signaling;stressor;Techniques;Testing;Therapeutic;Tissues;tool;transcription factor;Yeasts

PROJECT_TITLE: Elucidating the role of the Integrated Stress Response pathway in tissue homeostasis

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Immunotherapy;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Orphan Drug;Rare Diseases

PI_NAMEs: BERENS, MICHAEL E. (contact)

PROJECT_TERMS: Accreditation;Adoption;Aftercare;Alleles;Aneuploidy;Anti-CD47;Antibodies;Beds;Bioinformatics;bioinformatics pipeline;bioinformatics tool;Biological Products;biomedical informatics;Catheters;Cell Nucleus;Cells;Certification;Characteristics;Cities;CLIA certified;Clinic;Clinical;Clinical Data;Clinical Trials;Collaborations;Consultations;Data;Data Analytics;Data Reporting;Data Set;Decision Making;design;Development;DNA sequencing;Effectiveness;Eligibility Determination;Engineering;Enrollment;Ensure;Etoposide;Evolution;Excision;exome;exome sequencing;experimental study;feature selection;Fostering;Future;Gene Expression Profiling;Genes;genomic data;genomic profiles;genomic profiling;Genomics;Germ Lines;Glioblastoma;Glioma;Goals;Harvest;Herpesviridae;Herpesviridae Infections;immune cell infiltrate;immunological status;immunopharmacology;improved;improved outcome;Individual;Infection;Infiltration;Infrastructure;inhibitor;insight;Intervention;Laboratories;Lead;Liquid substance;Loss of Heterozygosity;Lymphocyte;Machine Learning;Manuscripts;Methods;Microdialysis;Mission;Modeling;Molecular;Molecular Profiling;Mus;Mutation;Normal tissue morphology;novel;Oncolytic;Oncolytic viruses;Operative Surgical Procedures;participant enrollment;Patient Care;patient derived xenograft model;Patients;Phenotype;Population;pre-clinical;Pre-Clinical Model;preclinical study;Predisposition;Process;programs;PTEN gene;Research;Research Personnel;Research Project Grants;Resistance;Resources;response;RNA;Running;Sampling;Secure;Services;Simplexvirus;Single Nucleotide Polymorphism;small molecule inhibitor;Specimen;Surgically-Created Resection Cavity;synergism;Techniques;Technology;Testing;The Cancer Genome Atlas;Therapeutic;Therapeutic Intervention;Tissue-Specific Gene Expression;Tissues;TOP2A gene;Transcript;transcriptome;transcriptome sequencing;transcriptomics;tumor;tumor heterogeneity;Tumor Tissue;tumor-immune system interactions;Variant;Work;Writing

PROJECT_TITLE: Molecular Profiling and Bioinformatics


NIH_SPENDING_CATS: Cancer

ORG_CITY: KANSAS CITY

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: PROJECT NARRATIVE This is a proposal for the University of Kansas Cancer Center K12 program, whose main goal is to train future cancer clinical and translational researchers. During the program, scholars will conduct rigorously designed research, receive mentorship and individualized development – so that they can become the next generation of independently funded cancer researchers. It is anticipated that scholars will apply for individual extramural funding upon completion of the program.

PI_NAMEs: CHEN, RONALD  (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: Advocate;Award;Basic Science;Cancer Center;career;Clinical;Clinical Oncology;Clinical Trials;Communication;Communities;Conduct Clinical Trials;curriculum development;design;Development;Device or Instrument Development;Diagnostic Equipment;Education;Educational process of instructing;Environment;Evaluation;experience;Faculty;Funding;Geography;Goals;Institution;Investigational Therapies;K-Series Research Career Programs;Kansas;Leadership;Malignant Neoplasms;Medical Device;member;Mentored Clinical Scientist Development Program;Mentors;Mentorship;parity;Patient Education;patient oriented;patient oriented research;Program Development;programs;recruit;Research;Research Personnel;Research Proposals;Resource Sharing;Science;skill acquisition;Therapeutic;Training;Training Programs;translational cancer research;Translational Research;translational scientist;Universities;Wages;Writing

PROJECT_TITLE: University of Kansas Cancer Center Paul Calabresi K12 Career Development Award for Clinical Oncology

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: NARRATIVE Point-of Care tests (POCT) to rapidly and accurately diagnose infectious diseases including sexually transmitted infections (STIs) and other emerging and re-emerging infections will impact global public health and improve outcomes. Our goal is to accelerate the development of affordable POCT innovation.

PI_NAMEs: MANABE, YUKARI C (contact)

PROGRAM_OFFICER_NAME: LASH, TIFFANI BAILEY

PROJECT_TERMS: Acceleration;accurate diagnosis;Adoption;Algorithms;Antibiotics;biobank;Biological Assay;Clinical;clinical development;clinical encounter;Clinical Research;clinical research site;commercialization;communicable disease diagnosis;Communicable Diseases;Conscious;Consultations;cost;COVID-19;COVID-19 detection;COVID-19 pandemic;COVID-19 point of care;Data;Decision Making;Detection;Development;Device or Instrument Development;Devices;Diagnosis;Diagnostic;diagnostic development;Diagnostic Equipment;diagnostic technologies;Diagnostic tests;disease diagnostic;emerging antimicrobial resistance;Emerging Communicable Diseases;Emerging infection;Engineering;Ensure;Environment;epidemic response;Evaluation;experience;FDA Emergency Use Authorization;Feedback;fitness;Funding;Goals;Health;Home;Human;Hybrids;improved outcome;In Vitro;Infection;innovation;Laboratories;Marketing;Modeling;Molecular;Molecular Target;multidisciplinary;Needs Assessment;overtreatment;Patient Recruitments;Patients;Performance;pilot test;Play;point of care;Point of Care Technology;point of care testing;point-of-care diagnostics;Positioning Attribute;pre-clinical;programs;prospective;Protocols documentation;prototype;Public Health;RADx Tech;rapid diagnosis;Recommendation;Research;research clinical testing;Resource-limited setting;Resources;Rest;Review Committee;Risk Factors;Sampling;self testing;Sexually Transmitted Diseases;success;Syndrome;targeted treatment;technological innovation;Technology;technology development;Test Result;Testing;Time;Training;Treatment Protocols;United States National Institutes of Health;Validation;Work

PROJECT_TITLE: Center for Innovative Diagnostics for Infectious Diseases


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases

PROJECT_TERMS: Acceleration;Accountability;Accounting;Address;Advisory Committees;Area;Awareness;biobank;Biomedical Engineering;Budgets;Clinical;Collaborations;Communicable Diseases;Communication;Communities;Complex;Consensus;Data;data dissemination;Databases;Development;Diagnostic;diagnostic development;Emerging Communicable Diseases;Engineering;Ensure;Evaluation;Funding;Goals;HIV;ID2 gene;improved;Individual;Industry;innovation;Laboratories;Leadership;material transfer agreement;Maternal Health;meetings;member;Monitor;Monkeypox;multidisciplinary;National Institute of Biomedical Imaging and Bioengineering;new technology;online course;outreach;Performance;Point of Care Technology;point-of-care diagnostics;pre-clinical;Process;Progress Reports;prototype;Public Health;Publications;RADx;RADx Tech;Research;Research Personnel;Resources;Scientist;Self Assessment;Services;Sexually Transmitted Diseases;Structure;support network;symposium;System;technological innovation;Technology;technology research and development;Testing;tool;United States National Institutes of Health;web site;Work


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Gene Therapy;Genetics;Immunization;Immunotherapy;Neurosciences;Orphan Drug;Rare Diseases

PI_NAMEs: CALIGIURI, MICHAEL A (contact)

PROJECT_TERMS: Adult;Adult Glioblastoma;Aftercare;analog;Animal Model;Anti-CD47;anti-tumor immune response;antibody immunotherapy;Antibody Therapy;Antibody titer measurement;antibody-dependent cell cytotoxicity;antibody-dependent cellular phagocytosis;Binding;Biological Markers;Biological Products;biomarker identification;Biopsy;Blood;Brain;cancer cell;Cancer Control;Cancer Model;cancer type;CD47 gene;CD47-SIRPα blockade;Cells;Chemistry;chemokine;Circulation;Clinical;Clinical Trials;Code;cohort;Collaborations;Correlative Study;cytokine;Cytolysis;data sharing;Development;Dose;Eating;efficacy study;Engineering;Extracellular Fluid;Fc Receptor;FDA approved;Foundations;Future;G207;Genes;Glioblastoma;Goals;good laboratory practice;Growth Factor;Half-Life;Herpesviridae;Herpesvirus 1;IgG1;IgG4;Immune;Immune response;Immunocompetent;Immunocompromised Host;immunodeficiency;Immunotherapy;improved;improved outcome;In Vitro;in vivo;Infusion procedures;innovation;insight;Institution;Integral Membrane Protein;Intravenous;intravenous administration;Investigational Drugs;Investigational New Drug Application;Length;Ligands;Macrophage;Malignant neoplasm of brain;Malignant Neoplasms;manufacture;Maximum Tolerated Dose;Mediating;Microdialysis;Modeling;Monitor;Monoclonal Antibodies;mortality;mouse model;Mus;Natural Killer Cells;neoplastic cell;Neurologic;novel;oncolysis;Oncolytic;oncolytic herpes simplex virus;oncolytic virotherapy;Oncolytic viruses;Organ;Outcome;Pathologic;Patients;peripheral blood;Phagocytosis;Phagocytosis Inhibition;Phase;phase 1 study;Phase I Clinical Trials;pre-clinical;preclinical safety;preclinical study;Process;Protocols documentation;PTPNS1 gene;Recommendation;Recurrence;response;response biomarker;Role;Safety;safety outcomes;safety study;scaffold;SHPS-1 protein;Signal Pathway;Signal Transduction;Simplexvirus;Site;small molecule inhibitor;System;systemic toxicity;Testing;Therapeutic Monoclonal Antibodies;timeline;Tissue Harvesting;Tissues;Toxic effect;tumor;Tumor Burden;tumor DNA;tumor progression;Virus;Virus Shedding;Work

PROJECT_TITLE: An engineered oncolytic herpes virus expressing a full-length α-CD47 mAb for the treatment of GBM


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Coronaviruses;Coronaviruses Diagnostics and Prognostics;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Sexually Transmitted Infections

PI_NAMEs: OSBURN, WILLIAM OWEN (contact)

PROJECT_TERMS: 2019-nCoV;Acceleration;Adoption;Award;Biological Assay;Clinical;Clinical Laboratory Improvement Amendments;Clinical Research;commercialization;Communicable Diseases;Communities;Consultations;cost;COVID-19 assay;COVID-19 detection;COVID-19 diagnostic;COVID-19 pandemic;COVID-19 point of care;design;Detection;Development;Devices;Diagnostic;diagnostic platform;diagnostic strategy;disease diagnostic;Educational workshop;Emerging infection;Engineering;Environment;Evaluation;experience;FDA Emergency Use Authorization;Funding;Goals;Health;Hour;in silico;innovation;interdisciplinary approach;Investments;Leadership;lectures;Letters;meetings;Methods;multidisciplinary;novel;Outcome;outreach;pathogen;Performance;Phase;point of care;Point of Care Technology;point of care testing;point-of-care diagnostics;Process;Public Health;Publications;RADx;RADx Tech;Research Personnel;Resource-limited setting;Resources;Risk;Sampling;Self Assessment;self testing;Services;Sexually Transmitted Diseases;simulation;Subjects Selections;success;System;technological innovation;Technology;technology development;Testing;Time;tool;United States National Institutes of Health;Validation;web site;Work

PROJECT_TITLE: Technology Core


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Coronaviruses;Coronaviruses Diagnostics and Prognostics;Coronaviruses Disparities and At-Risk Populations;Emergency Care;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Pediatric;Sexually Transmitted Infections

PI_NAMEs: HAMILL, MATTHEW  (contact)

PROJECT_TERMS: 2019-nCoV;Acceleration;Accident and Emergency department;Adolescent;Adopted;Adult;Bacterial Vaginosis;Baltimore;biobank;Biological Assay;Businesses;Child;Childhood;Chlamydia trachomatis;Cities;Clinic;Clinical;Clinical Research;clinical research site;Collection;commercialization;Communicable Diseases;Communities;Community Pharmacy;Coronavirus;COVID-19;COVID-19 pandemic;Data;Development;Devices;Diagnostic;disease diagnostic;distributed archives;Emergency Medicine;Emerging Communicable Diseases;Emerging infection;Evaluation;evaluation/testing;Excision;experience;FDA Emergency Use Authorization;Feedback;Freezing;Goals;Health;health care settings;HIV;Home;In Vitro;Infection;innovation;Institutional Review Boards;Internet;laboratory experience;Link;material transfer agreement;medical specialties;meetings;Modeling;Monkeypox;Mycoplasma genitalium;Neisseria gonorrhoeae;pandemic influenza;Patient Care;Patient Recruitments;Performance;Pharmacy facility;Pilot Projects;pilot test;point of care;Point of Care Technology;point of care testing;point-of-care diagnostics;Population;Positioning Attribute;pre-clinical;preference;prospective;prospective test;Protocols documentation;prototype;Public Health;RADx Tech;recruit;reproductive tract;Research;Research Design;Research Personnel;Resistance;Resource-limited setting;Resources;respiratory pathogen;Review Committee;sample archive;Sampling;SARS-CoV-2 infection;self testing;Services;Sexually Transmitted Diseases;Simplexvirus;Site;Specific qualifier value;Specificity;Syphilis;technological innovation;Technology;Testing;Trichomonas vaginalis;Uganda;United States National Institutes of Health;usability;Validation;Work;Writing

PROJECT_TITLE: Clinical Core


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Biodefense and Related Countermeasures;Biotechnology;Brain Disorders;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Genetics;Human Genome;Infectious Diseases;Neurosciences

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: PROJECT NARRATIVE The current proposal is highly relevant to public health and to the NIA’s mission of advancing knowledge on the causes of aging processes and age-associated diseases to extend healthy lifespan. This funding opportunity is critical as it will allow me to change my research field to one, spatial transcriptomics applied to brain aging, that I currently do not have preliminary data for. I will use my expertise in neural function and in non-coding RNAs to identify key factors involved in accelerated brain aging that can be targeted to delay or reverse brain aging.

PI_NAMEs: MAVRIKAKI, MARIA  (contact)

PROGRAM_OFFICER_NAME: MARIC, MAJA

PROJECT_TERMS: 2019-nCoV;Acceleration;adeno-associated viral vector;Adult;Age;age acceleration;age effect;age-related disease;aged;Aging;aging brain;aging mechanism;aging process;aging related;Autopsy;Binding Sites;Bioinformatics;Biological Assay;Brain;Cell Aging;cell type;Cognition;Cognitive deficits;cognitive function;Coronavirus Infections;COVID-19;COVID-19 impact;COVID-19 pandemic;COVID-19 patient;Data;Development;differential expression;Disease;Environmental Risk Factor;frontal lobe;Functional disorder;Funding Opportunities;Gene Expression;Gene Expression Profile;Gene Expression Regulation;Genes;Genetic Transcription;Goals;healthspan;Human;Impaired cognition;In Vitro;in vitro Assay;in vivo;Individual;Induced Neurons;induced pluripotent stem cell;Intervention;Knowledge;life span;Luciferases;Maps;Measures;Messenger RNA;MicroRNAs;Mission;Molecular;Molecular Profiling;mouse model;Mus;Neurodegenerative Disorders;Neurons;neuropathology;Neurophysiology - biologic function;new therapeutic target;Normal tissue morphology;novel;old mice;Phenotype;Play;prevent;promoter;Public Health;Publishing;Recording of previous events;Regulator Genes;Reporter;Research;Research Personnel;Research Project Grants;response;Risk Factors;senescence;severe COVID-19;single-cell RNA sequencing;Site-Directed Mutagenesis;Small RNA;Spatial Distribution;Technology;Testing;Therapeutic;therapeutic development;Tissues;transcriptome sequencing;transcriptomics;Untranslated RNA;Validation;Ventilator;Virus;Virus Diseases

PROJECT_TITLE: Molecular mechanisms of aging and accelerated aging in the human brain

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

ORG_CITY: HOUSTON

ORG_NAME: RICE UNIVERSITY

PHR: Narrative: Early detection of cancer and pre-cancerous lesions improves outcomes and reduces the cost and pain associated with treatment. Better tools are needed to improve early detection of cancer at the point-of-care, especially in medically underserved communities. The Center for Innovation and Translation of Point-of-Care Technologies for Equitable Cancer Care (CITEC) will accelerate the development and adoption of new technologies that can be used to improve the early detection of cancer in low-resource settings in the US and globally.

PI_NAMEs: ANANDASABAPATHY, SHARMILA ;RICHARDS-KORTUM, REBECCA R. (contact);TKACZYK, TOMASZ S

PROJECT_TERMS: Acceleration;Accounting;Address;Adoption;anti-cancer research;Anus;Award;Brazil;cancer care;Cancer Detection;cancer health disparity;Cancer Hospital;Cancer Patient;cancer prevention;cancer therapy;cancer type;Caring;Cervix Uteri;Cessation of life;Clinical;Collaborations;college;Colon;commercialization;Communities;Complex;cost;Country;Dedications;Development;Diagnosis;Disease;Disparity;disparity reduction;Diverse Workforce;Early Diagnosis;Early treatment;Engineering;Ensure;Epithelium;Equity;Esophagus;ethnic minority;Evaluation;Gastrointestinal tract structure;Goals;Health;Health Sciences;Human Development;implementation barriers;improved;improved outcome;Incidence;indexing;Industrialization;Infrastructure;innovation;Lesion;low and middle-income countries;Malignant Neoplasms;medically underserved;Medically Underserved Area;medically underserved population;Medicine;meetings;member;mortality;Mozambique;new technology;novel;Oral cavity;Organ;Outcome;Pain;Palliative Care;Performance;personalized approach;point of care;Point of Care Technology;point of care testing;premalignant;premature;preventable death;Prevention;Prevention approach;Prevention program;prevention service;Primary Care;primary care setting;Process;Productivity;prototype;Public Health;racial minority;Recommendation;Rectum;Research;Research Personnel;Resource-limited setting;Resources;Rice;Scientist;screening;Screening for cancer;Site;Stomach;Suggestion;Surface;Sustainable Development;Technology;technology development;technology research and development;Testing;Texas;tool;Training;training opportunity;Translating;Translations;underserved community;United States National Institutes of Health;Universities;University of Texas M D Anderson Cancer Center;usability;Work;World Health Organization

PROJECT_TITLE: The Center for Innovation and Translation of Point of Care Technologies for Equitable Cancer Care (CITEC)


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Immunotherapy;Neurosciences;Orphan Drug;Rare Diseases

PROJECT_TERMS: Ablation;Adrenal Cortex Hormones;Anti-Inflammatory Agents;anti-PD-1;anti-tumor immune response;autocrine;Binding;Biological Products;Brain;Brain Edema;Brain Injuries;Brain Neoplasms;brain surgery;cancer type;Catheters;Cells;Cerebral Edema;Cerebral Edema Management;Chemicals;chemokine;chimeric antigen receptor T cells;Clinical Trials;Conduct Clinical Trials;Correlative Study;cytokine;Data;data sharing;Development;Dexamethasone;Dose;Drug Kinetics;efficacy evaluation;Encephalitis;Environment;Excision;Feasibility Studies;Foundations;Future;Glioblastoma;Glioma;Goals;Growth;Immune;Immune response;Immune system;Immunologics;immunoregulation;Immunosuppression;Immunotherapeutic agent;Immunotherapy;improved;improved outcome;in vivo;Inflammation;Inflammatory;inflammatory marker;Inflammatory Response;Institution;Ligands;Liquid substance;Malignant Neoplasms;manufacture;Maximum Tolerated Dose;Measures;Microdialysis;mouse model;Mus;Myelogenous;Myeloid-derived suppressor cells;Neoadjuvant Therapy;neoplastic cell;novel;novel strategies;Oncolytic viruses;Operative Surgical Procedures;Pathway interactions;Patient-Focused Outcomes;Patients;PD-1 inhibitors;Perioperative;Phase;phase 1 study;Play;Population;Postoperative Period;pre-clinical;preclinical efficacy;Process;Property;Protocols documentation;receptor;receptor for advanced glycation endproducts;Reporting;Research Project Grants;response;Role;S100A9 gene;Safety;safety and feasibility;Site;small molecule inhibitor;standard of care;success;Surgically-Created Resection Cavity;Technology;timeline;tissue trauma;Toxicology;trafficking;treatment duration;tumor;tumor microenvironment;tumorigenic;Up-Regulation;Work

PROJECT_TITLE: Tasquinimod as an adjunct to immunotherapies administered peri-operatively


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Clinical Research;HIV/AIDS;Infectious Diseases;Sexually Transmitted Infections

PI_NAMEs: TUDDENHAM, SUSAN ANNE (contact)

PROJECT_TERMS: Acceleration;Administrator;Adoption;Award;Characteristics;Clinical;clinical care;Clinical Pathways;Collaborations;Communicable Diseases;Communication;Communities;cost;COVID-19 pandemic;COVID-19 testing;Data;design;Detection;Development;Device Designs;Devices;Diagnosis;Diagnostic;Diagnostic tests;Discipline;Disease Outbreaks;E-learning;Educational workshop;Emerging infection;Engineering;Epidemic;Epidemiologist;Event;Feedback;Focus Groups;Future;Goals;Grant;Health;Health system;Healthcare Systems;HIV;Home;home test;Incidence;Individual;Industry;innovation;International;large scale production;lectures;low and middle-income countries;Marketing;Medical;Modeling;Needs Assessment;pandemic disease;Patients;Persons;Pharmacists;Phase;point of care;Point of Care Technology;point of care testing;point-of-care diagnostics;Policy Maker;population health;Preceptorship;Process;Public Health;Publications;Readiness;Reporting;Research Personnel;Respondent;Risk;routine screening;Scientist;self testing;Sexual Health;Sexually Transmitted Diseases;Site;stakeholder perspectives;symposium;Symptoms;System;Systems Integration;technological innovation;Technology;Test Result;Testing;Time;Training;training opportunity;Translations;Update;uptake;webinar;Work

PROJECT_TITLE: Dissemination Core


NIH_SPENDING_CATS: Bioengineering;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention

PHR: According to Instructions for the Submission of Mulit-Component Applications in PAR-22-203, for Administrative, Technology, Clinical and Dissemination Cores: “Project Narrative: Do not complete. Note: ASSIST screens will show an asterisk for this attachment indicating it is required. However, eRA systems only enforce this requirement in the Overall component and applications will not receive an error if omitted in other components.”

PI_NAMEs: RICHARDS-KORTUM, REBECCA R. (contact)

PROJECT_TERMS: Acceleration;Address;Advisory Committees;Algorithms;Anus;biomedical imaging;Brazil;Budgets;cancer care;cancer prevention;Carcinoma;Caring;Cervix Uteri;Cessation of life;Clinical;Collaborations;Colon;commercialization;Communication;community partners;conflict resolution;Data;Decision Making;design;Development;Diagnostic;Disease;Early Diagnosis;Engineering;Ensure;Epithelium;Equity;Esophagus;Evaluation;Feedback;Funding;Gastrointestinal tract structure;Goals;Imaging Device;imaging system;improved;In Vitro;in vivo imaging;in-vitro diagnostics;Incidence;Individual;industry partner;Inequity;innovation;Instruction;Knowledge;Leadership;Lesion;Malignant Neoplasms;manufacture;member;Mission;Molecular;mortality;Mozambique;multidisciplinary;Office of Administrative Management;Oral cavity;Organ;Performance;Point of Care Technology;Policies;premalignant;prevent;Process;Productivity;programs;Protocols documentation;Public Health;Rectum;Research;Research Personnel;Resources;Scientist;Screening for cancer;sensor;Site;socioeconomic disparity;Stomach;Structure;System;Techniques;Technology;Testing;Tissues;tool;Translations;United States National Institutes of Health;Voting Right;Work

PROJECT_TITLE: The Center for Innovation and Translation of Point of Care Technologies for Equitable Cancer Care (CITEC) - Administrative Core