NIH_SPENDING_CATS: Aging;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

PROJECT_TERMS: Advisory Committees;African American;Aging;Alabama;Applications Grants;Award;Behavioral;Biological;Biometry;Black race;career;career development;Collaborations;Communication;Communities;Country;Deep South;design;Disparity;Education;education research;Ensure;Epidemiology;Ethics;Evaluation;Faculty;Feedback;Funding;Goals;Grant;Health;health care disparity;Health Disparities Research;health disparity;Health Services Research;Historically Black Colleges and Universities;Human Resources;Institution;Institutional Review Boards;Leadership;Mentors;Mentorship;Minority;Minority Health Research;minority investigator;Minority Recruitment;Monitor;Morehouse School of Medicine;multidisciplinary;National Institute on Aging;older adult;operation;parent grant;Persons;Process;Program Effectiveness;programs;recruit;Reduce health disparities;Regulation;Research;Research Activity;Research Methodology;Research Personnel;Research Support;Resource Development;Resources;Role;rural setting;Scientist;Site;social;social culture;United States National Institutes of Health;Universities;urban setting;Work


ADMINISTERING_IC: AG

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Clinical Research

ORG_CITY: BALTIMORE

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PI_NAMEs: BROWN, TODD T (contact)

PROJECT_TERMS: Acceleration;Address;Aging;aging related;American;Articulation;Biological;career;Categories;Clinical;Clinical and Translational Science Awards;clinical investigation;clinical practice;Clinical Research;clinical training;clinical translation;Clinical Trials;Cognition;Collaborations;Communities;community advisory board;community engagement;Consent;Data;Data Analyses;Data Collection;design;Development;Development Plans;Diabetes Mellitus;Doctor of Philosophy;Documentation;education research;Endocrine System Diseases;Endocrinology;Ensure;Epidemiology;epidemiology study;Etiology;experience;Fostering;frailty;Funding;Future;Geriatrics;Gerontology;Goals;health equity;Health Technology;HIV;human subject;human subject protection;Human Subject Research;Infrastructure;Institutional Review Boards;Intervention;investigator training;Leadership;Maintenance;Measurement;medical schools;Medicine;Mentorship;metabolic abnormality assessment;Metabolic Diseases;Metabolism;Minority Groups;Minority Recruitment;Monitor;older adult;Outcome;Participant;Performance;Physical Function;Physiological;Play;Preparation;Procedures;professor;programs;protocol development;recruit;Registries;Research;Research Design;Research Infrastructure;Research Personnel;Research Project Grants;Resources;Role;Safety;Services;skills;success;synergism;technology development;Training;Translational Research;Translations;Underrepresented Minority;Universities;Venous blood sampling;Work

PROJECT_TITLE: Clinical Translation Core - RC3


ADMINISTERING_IC: EY

ED_INST_TYPE: SCHOOLS OF OPTOMETRY/OPHT TECH

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: BIRMINGHAM

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PI_NAMEs: WANG, YUCHEN  (contact)

PROGRAM_OFFICER_NAME: WRIGHT, CHARLES BAKER

PROJECT_TERMS: Adopted;Affect;Axon;Calcium Channel;Cell Adhesion Molecules;Complex;Cone;Deletion Mutagenesis;Electrophysiology (science);Electroporation;extracellular;in vivo;information processing;Inner Plexiform Layer;innovation;Leucine-Rich Repeat;leucine-rich repeat protein;Mediating;Mentors;neural circuit;Neural Retina;neurotransmitter release;Phase;Photoreceptors;postsynaptic;presynaptic;Proteins;receptor;Receptor Signaling;Reporting;Retina;retinal neuron;retinal rods;ribbon synapse;Rod;Role;Site;Synapses;synaptic function;Synaptic Receptors;synaptogenesis;Techniques;Testing;visual information;visual performance;Work

PROJECT_TITLE: Trans-synaptic mechanism of retinal synapse formation and function

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


PI_NAMEs: CLAY, OLIVIO J (contact)

PROJECT_TERMS: Address;African American;Aging;Alabama;Alzheimer's disease related dementia;Area;Award;Biometry;Black race;Budgets;career;Clinical;Collaborations;Communication;Communities;Country;Data;Data Analyses;data resource;Data Set;Deep South;Development;Economics;education research;equity, diversity, and inclusion;Evaluation;Funding;Genetic;Goals;Health Disparities Research;health disparity;Historically Black Colleges and Universities;Individual;Infrastructure;Institution;Intervention;Manuscripts;Measurement;Measures;Mentors;Methodology;Methods;Minority;Minority Health Research;Morehouse School of Medicine;Not Hispanic or Latino;older adult;Participant;Population Heterogeneity;Positioning Attribute;Principal Investigator;Productivity;programs;psychosocial;Psychosocial Assessment and Care;recruit;Reduce health disparities;Research;research faculty;Research Methodology;Research Peer Review;Research Personnel;Resources;Sampling;Scientist;secondary analysis;social health determinants;Structure;Techniques;Time;Training;Universities;Validity and Reliability;Vision;Workplace

PROJECT_TITLE: Analysis Core


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Genetics;Hematology;Human Genome;Precision Medicine;Rare Diseases

ORG_CITY: RICHLAND

ORG_NAME: BATTELLE PACIFIC NORTHWEST LABORATORIES

ORG_STATE: WA

PHR: NARRATIVE The origination and progression of cancer remain largely unknown due to the lack of effective approaches for the comprehensive characterization of tumor heterogeneity. The goal of this project is to develop and validate a next-generation proteomics platform to enable the characterization of massive single cells based on microfluidic sample preparation and mass spectrometry. The new platform will allow us to assess the heterogeneity of tumor cells and their interactions with the microenvironment.

PI_NAMEs: PASA-TOLIC, LJILJANA  (contact)

PROGRAM_OFFICER_NAME: BYUN, JUNG SHIN

PROJECT_TERMS: Address;Architecture;Benchmarking;Bone Marrow;Cancer Biology;cancer proteomics;Cell Physiology;cell preparation;Cell Separation;Cells;Cellular biology;chimeric antigen receptor T cells;Clinical;Clinical Treatment;Collaborations;Communities;computational pipelines;cost efficient;Coupling;Data;data acquisition;density;Diagnosis;Digestion;Disease Progression;Disease Resistance;Environment;Evolution;Goals;Hematopoietic Neoplasms;Heterogeneity;Human;Immune;improved;Individual;individual variation;innovation;insight;Isotope Labeling;Knowledge;Label;Laboratories;Liquid substance;Malignant - descriptor;Malignant Neoplasms;Mass Spectrum Analysis;Methods;microchip;Microfluidics;Molecular;Multiple Myeloma;nanoDroplet;Nature;neoplastic cell;next generation;next generation sequencing;Outcome;Pathogenesis;Pathologic;Patients;Performance;Peripheral Blood Mononuclear Cell;personalized medicine;Phenotype;Plasma;Plasma Cells;Population;Post-Translational Protein Processing;Preparation;Process;protein biomarkers;protein expression;protein profiling;Proteins;Proteome;Proteomics;relapse patients;Research;Resistance;RNA;Running;Sampling;single cell genomics;single cell technology;single-cell RNA sequencing;Somatic Cell;Specimen;success;System;Technology;Therapeutic;therapy resistant;Transcript;transcriptomics;tumor;tumor heterogeneity;tumor progression;tumor-immune system interactions;Universities;Washington;Yeasts

PROJECT_TITLE: Massive single cell proteomics for cancer biology


NIH_SPENDING_CATS: Aging;Bioengineering;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention

PI_NAMEs: DEHAK, NAJIM  (contact)

PROJECT_TERMS: Acceleration;Accelerometer;Address;Aging;aging and technology;Algorithms;Alzheimer's Disease;American;Artificial Intelligence;Biological;Biomedical Engineering;Businesses;Cardiac;Caring;Clinical Data;clinical investigation;Clinical Investigator;Clinical Research;Collaborations;collaboratory;Complex;Computer Vision Systems;Data Scientist;design;Detection;Development;Diagnosis;Diagnostic;digital health;Ecosystem;Electrocardiogram;Electronics;Engineering;Event;Fall prevention;Frail Elderly;frailty;Funding;Gait;Global Positioning System;Goals;graduate student;Growth;Health;Health Technology;Healthcare;heart rate monitor;improved;Incubators;Infrastructure;International;Intervention;Leadership;Measurement;medication compliance;Mentorship;Mind;Modality;Natural Language Processing;new technology;novel;novel strategies;older adult;Older Population;Personal Satisfaction;Pharmaceutical Preparations;Pilot Projects;prevent;Prevention;programs;Public Health;Research;Research Design;Research Personnel;Resources;Risk;robot assistance;Robotics;rural area;Schools;Science;Signal Transduction;Technology;Technology Assessment;technology development;technology intervention;Testing;tool;Training;Translations;treatment adherence;undergraduate student;Underserved Population;urban area;Work

PROJECT_TITLE: Technological Assessment and Solutions Core - RC4


ADMINISTERING_IC: HD

ED_INST_TYPE: SCH OF HOME ECON/HUMAN ECOLOGY

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Brain Disorders;Clinical Research;Down Syndrome;Health Services;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric;Prevention

ORG_CITY: FORT COLLINS

ORG_NAME: COLORADO STATE UNIVERSITY

ORG_STATE: CO

PHR: Narrative This project aims to identify developmental and biomedical markers of risk for autism spectrum disorder (ASD) in young children with Down syndrome to advance early screening procedures. This project will focus on two areas of potential ASD risk: (1) developmental presentation during early childhood and (2) co-occurring biomedical conditions. Results will inform revised recommendations regarding early ASD screening in children with Down syndrome ages 18 to 45 months, which will be disseminated to medical providers, interventionists, and researchers aiming to advance treatment for ASD and other co- occurring conditions associated with Down syndrome.

PI_NAMEs: BAUMER, NICOLE ;BISHOP, SOMER L.;FIDLER, DEBORAH J (contact)

PROGRAM_OFFICER_NAME: PARISI, MELISSA

PROJECT_TERMS: 1 year old;Accounting;Adaptive Behaviors;Address;Age;Area;autism spectrum disorder;autism symptoms;autistic children;Behavior;biomarker identification;care costs;Child;Clinical;clinical care;Cognition;cohort;Communication;Communities;community based participatory research;Congenital Heart Defects;Consensus;Data;Data Coordinating Center;design;Development;Diagnosis;Dimensions;disorder risk;Down's Syndrome;early childhood;Early Diagnosis;Early identification;Early Intervention;early onset;early screening;Eligibility Determination;Epilepsy;gastrointestinal;General Population;Growth;Health;improved;indexing;Individual;Infantile spasms;information gathering;innovation;Intellectual functioning disability;Low Birth Weight Infant;maladaptive behavior;Measures;Medical;Modeling;Mosaicism;Motor Skills;neurogenetics;Outcome;Personal Satisfaction;Persons;Phenotype;Population;premature;Premature Birth;Preventive;Probability;Prospective cohort;Provider;Quality of life;Recommendation;Recording of previous events;recruit;Research;Research Personnel;Research Project Grants;response;Risk;Risk Factors;Risk Marker;Science;screening;Screening procedure;service intervention;sex;Sleep Disorders;Sleep disturbances;social communication;Specificity;Testing;tool;United States National Institutes of Health;Work

PROJECT_TITLE: Autism in Young Children with Down Syndrome

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


ED_INST_TYPE: SCHOOLS OF MEDICINE

NIH_SPENDING_CATS: Bioengineering;Chronic Pain;Clinical Research;Eye Disease and Disorders of Vision;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Pain Research

ORG_CITY: DURHAM

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE Eye pain, which is associated with dry eye disease and other conditions, is difficult to manage and can lead to a significant loss in quality of life. Though nerve cells in the cornea play a role in eye pain, the exact processes are unknown. The focus of this grant is to understand corneal nerve cells in greater depth and thereby lay the groundwork for future identification of new drug targets to treat eye pain and dry eye disease.

PI_NAMEs: FARSIU, SINA ;PEREZ, VICTOR L;SABAN, DANIEL RAPHAEL (contact)

PROGRAM_OFFICER_NAME: ARAJ, HOUMAM H

PROJECT_TERMS: 3-Dimensional;Ablation;analog;Anatomy;artificial intelligence method;Atlases;automated segmentation;Axon;behavior prediction;Behavioral;Biological Assay;blink reflexes;Blinking;Brain Stem;Catalogs;Categories;Cells;Classification;Clinical Research;Color;Complex;Computer software;Cornea;Coupled;Data;Data Set;density;Development;differential expression;Dimensions;Disabling;Dissection;Dry Eye Syndromes;Electrophysiology (science);experimental study;Eye;eye dryness;Foundations;Future;Generations;Genes;Genetic;genetic approach;Genomics;Grant;grasp;Homeostasis;Human;human subject;Image;Image Analysis;imaging Segmentation;Immunofluorescence Immunologic;Infection;Ions;Knowledge;Label;Lacrimation;Link;Machine Learning;machine learning classification;Macrophage;Maintenance;Maps;Mediating;Microscopy;Modeling;Molecular;Morphology;Mouse Strains;multidisciplinary;multiple datasets;Mus;Nature;Nerve;Nerve Fibers;Nerve Plexus;neuronal circuitry;Neurons;Neuropathy;neurotransmission;new therapeutic target;Nociception;Nociceptors;novel strategies;ocular pain;ocular surface;open source;Output;Pain;patch clamp;Pattern;pharmacologic;Population;Process;Production;Property;Pseudomonas aeruginosa;Quality of life;reflectance confocal microscopy;Reflex action;Resolution;response;segmentation algorithm;Signal Transduction;Structure;Structure of trigeminal ganglion;Tissues;transcriptome;transcriptome sequencing;Translational Research;Trigeminal System;Validation;Work

PROJECT_TITLE: Blink, Lacrimation, and Nociception: Precision Mapping and Integrated Atlas Generation of Corneal Trigeminal Afferents


NIH_SPENDING_CATS: Aging;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

PI_NAMEs: BALL, KARLENE K (contact)

PROJECT_TERMS: Address;African American population;age related;Aging;Alabama;Applications Grants;Area;Automobile Driving;Award;Behavioral;behavioral and social science;Behavioral Research;Bioethics;Black race;career;career development;Clinical Research;Collaborations;Communities;Country;Cultural Sensitivity;Deep South;design;Development;Discipline;early-career faculty;editorial;Education;education research;Ensure;expectation;experience;Exposure to;Faculty;faculty support;Fostering;Foundations;Funding;Future;Goals;Grant;Health;Health Disparities Research;health disparity;health inequalities;Historically Black Colleges and Universities;Home;human old age (65+);improved;Infrastructure;innovation;Institution;interest;Intervention;Intervention Studies;Leadership;Mentors;Mentorship;Methodology;Minority;Mission;Morehouse School of Medicine;Occupational activity of managing finances;older adult;Older Population;Outcomes Research;peer coaching;Pilot Projects;Preparation;programs;Publications;Publishing;recruit;Reduce health disparities;Research;Research Activity;Research Infrastructure;Research Personnel;Research Project Grants;Research Support;Resources;responsible research conduct;Role;Rural;rural area;Science;Scientist;Services;social;Social Sciences;Study Section;success;theories;tool;Training;Underrepresented Populations;Universities;webinar;Work;Writing

PROJECT_TITLE: Research Education Core


NIH_SPENDING_CATS: Aging;Clinical Research;Prevention

PI_NAMEs: FEDARKO, NEAL S (contact)

PROJECT_TITLE: Pilot/Exploratory Studies Core


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

PI_NAMEs: CROWTHER, MARTHA R (contact)

PROJECT_TERMS: Address;Advocacy;African American population;Aging;Area;Behavior;behavior change;Black race;catalyst;Church;Clinical Research;cohort;Communities;community academic partnership;community engaged approach;community engagement;Community Health;Community Health Education;community involvement;community partners;cultural values;Deep South;design;Development;Economics;education research;Elderly;Equity;evidence base;Family;Fostering;Funding;Goals;Grant;Health;Health behavior;Health education;Health Promotion;Individual;Infrastructure;Institutional Policy;interest;Intervention;Intervention Studies;Kinship Networks;Knowledge;member;Mentors;Minority;Participant;perceived discrimination;Politics;public health relevance;racism;recruit;recruitment science;Religious Belief;Research;Research Project Grants;research study;Resources;retention rate;Role;Route;Rural;Rural Community;Science;Scientific Advances and Accomplishments;Scientist;Secure;segregation;social;Social Behavior;System;Testing;Textiles;theories;Theory of Change;tool;Training;Urban Community;Work

PROJECT_TITLE: Community Liaison and Recruitment Core


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Clinical Research;Clinical Trials and Supportive Activities;Contraception/Reproduction;Digestive Diseases;Hepatitis;Liver Disease;Nutrition;Polycystic Ovary Syndrome (PCOS);Women's Health Research

ORG_CITY: SAN FRANCISCO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE The public health implications of nonalcoholic steatohepatitis (NASH) in young adults is vast, and given limited therapies and the heterogeneity of affected individuals, there is an urgent and unmet need to identify tailored therapeutic targets for distinct at-risk populations. Androgens may reflect such target for the 10-15%, or nearly 10 million reproductive-aged women with Polycystic Ovary Syndrome (PCOS), a common endocrinopathy with classically elevated androgens, that is marked by early onset NAFLD and greater risk of NASH. In the proposed study, we will determine whether androgens are the driver of NASH severity and progression in PCOS and the mechanistic contributions of visceral fat and aberrant lipid metabolism to this process – findings that are directly relevant to future efficacy studies evaluating androgen modulation in these young women with early onset liver disease.

PI_NAMEs: SARKAR, MONIKA  (contact)

PROGRAM_OFFICER_NAME: LOH, KATRINA SHUEH WEN

PROJECT_TERMS: Adipose tissue;Adult;Affect;Age;age group;aged;amino acid metabolism;Amino Acids;Androgen Receptor;androgenic;Androgens;antagonist;Bicalutamide;Biochemical;Branched-Chain Amino Acids;Ceramides;Cirrhosis;Clinical;cohort;Collaborations;comorbidity;Data;Disease Progression;Dyslipidemias;early onset;efficacy study;Enrollment;Equilibrium;Evaluation;Fatty acid glycerol esters;Fatty Liver;Fibrosis;Future;General Population;Glycerophospholipids;Head Start Program;Hepatic;Hepatocyte;Heterogeneity;high risk population;Histology;Hormonal;Human;Hyperandrogenism;Image;improved;Individual;Infrastructure;Insulin Resistance;Keto Acids;Link;lipid biosynthesis;lipid metabolism;Lipids;Liver;Liver diseases;liver injury;liver stiffness;Longitudinal Studies;Magnetic Resonance Elastography;Measures;Mediating;Metabolic;new therapeutic target;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;Normal Range;Obesity;Participant;Pathway interactions;Patients;personalized approach;Pharmacotherapy;Phenotype;Phospholipids;Placebos;Polycystic Ovary Syndrome;Population;Populations at Risk;Positioning Attribute;precision medicine;Premenopause;Process;Production;Public Health;receptor expression;reproductive;Research Personnel;Risk;Role;Serum;Severities;Severity of illness;Source;Sphingomyelins;subcutaneous;Testosterone;therapeutic target;Tissues;translational scientist;United States;Universities;Visceral;Visceral fat;Woman;Women's Group;young adult;young woman

PROJECT_TITLE: Nonalcoholic Fatty Liver Disease (NAFLD) in Polycystic Ovary Syndrome: The Role of Androgens on Liver Injury and NAFLD Progression

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


PI_NAMEs: GERSTENBLITH, GARY  (contact)

PROJECT_TERMS: Age;Aging;aging related;American;Area;Award;Basic Science;Benchmarking;career;career development;Career Mobility;Clinical;clinical investigation;Clinical Management;Collaborations;Communication;Communities;Complement;Dedications;Discipline;diversity and inclusion;doctoral student;early-career faculty;Education;education research;Educational workshop;Elements;Eligibility Determination;Ensure;Ethnic Population;Faculty;faculty support;frailty;Funding;Future;Goals;Grant;Group Meetings;Health;health equity promotion;Health Personnel;Home;improved;Individual;Information Dissemination;Infrastructure;Institution;Instruction;interest;Intervention;Investments;K-Series Research Career Programs;Lead;Leadership;Learning;lectures;meetings;Mentors;Mentorship;Methodology;Monitor;older adult;Positioning Attribute;Postdoctoral Fellow;pre-doctoral;Prevention strategy;programs;Public Health Schools;Qualifying;racial population;Research;Research Infrastructure;Research Personnel;Research Project Grants;Resources;Scholarship;Science;Section 8;Secure;Services;Site;skills;Stimulus;Structure;success;symposium;System;Time;tool;Training;Training Activity;Translating;Translations;Universities;Wages;Work;working group

PROJECT_TITLE: Research Education Component


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Cancer

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Project Narrative: Only a small number of surgeons perform research aimed at improving outcomes of cancer patients by safely introducing scientific breakthroughs to their care and management. We propose to train young surgeons and associated physicians, including those from traditionally under-represented minorities, to perform this research throughout their careers and to increase the survival and quality of life of patients suffering from cancer

PI_NAMEs: SHOWALTER, SHAYNA LEFRAK;SLINGLUFF, CRAIG LEE (contact)

PROGRAM_OFFICER_NAME: BOULANGER-ESPEUT, CORINNE A

PROJECT_TITLE: Postdoctoral Training Grant for MDs in Surgical Oncology Research

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


ORG_CITY: IRVINE

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: PROJECT NARRATIVE Although obesity is a major risk factor for type 2 diabetes, only about 30% of obese patients develop diabetes due to their genetic risk. The current proposal identifies genetic variants that reduce a gene called ZC3H13, leading to impaired function of insulin-producing cells. The results may help develop tools to identify high-risk obese patients for diabetes prevention and early intervention.

PI_NAMEs: YANG, QIN  (contact)

PROGRAM_OFFICER_NAME: ZAGHLOUL, NORANN

PROJECT_TERMS: 3' Untranslated Regions;Beta Cell;Binding;Binding Proteins;Binding Sites;Biological Assay;causal variant;Cell Nucleus;Cell Physiology;Cells;Complex;CRISPR/Cas technology;Data;deep learning model;Development;Diabetes Mellitus;Diabetes prevention;diabetes risk;diabetic;Disease;Distal;Early Intervention;epitranscriptomics;Exhibits;Failure;Gene Expression;gene function;Genes;Genetic Predisposition to Disease;Genetic Risk;genetic risk factor;genetic variant;genome editing;genome wide association study;Genotype;Genotype-Tissue Expression Project;Heterozygote;High Fat Diet;high risk;Human;impaired glucose tolerance;Impairment;Insulin;Insulin deficiency;Insulin Resistance;islet;knock-down;Knock-out;Knockout Mice;Length;Link;Linkage Disequilibrium;Maps;Mediating;Messenger RNA;Methyltransferase;MicroRNAs;Modification;molecular phenotype;Mutagenesis;Non-Insulin-Dependent Diabetes Mellitus;novel;Nuclear;obese patients;obese person;Obesity;Overweight;Pancreas;Pathogenesis;Patients;Polyadenylation;Positioning Attribute;Post-Transcriptional Regulation;preventive intervention;Production;protein expression;protein function;Protein Isoforms;Proteins;Proteomics;Quantitative Trait Loci;Regulation;Regulatory Element;Risk;Risk Factors;RNA;RNA Processing;RNA-Binding Proteins;Site;statistics;Susceptibility Gene;tool;Transcript;transcriptome sequencing;transcriptomics;Untranslated RNA;Variant;Zinc Fingers

PROJECT_TITLE: Alternative polyadenylation as a novel mechanism for diabetes

STUDY_SECTION: BMDM

STUDY_SECTION_NAME: Basic Mechanisms of Diabetes and Metabolism Study Section[BMDM]


ADMINISTERING_IC: HL

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Emergency Care;Health Services;Lung;Patient Safety;Prevention

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PROJECT NARRATIVE Thousands of critically ill adults require placement of an endotracheal tube in emergency departments each year, with up to one-in-five experiencing hypoxemia and one-in-forty experiencing cardiac arrest. Yet the optimal approach to providing bag-mask ventilation, the most effective tool in preventing hypoxemia, remains unknown in this setting. Therefore, we designed the SAFEty of bag-mask VENTilation in the ED (SAFE- VENTED) study, to determine the effect of bag-mask ventilation on hypoxemia during tracheal intubation in the ED and to provide critical preliminary data for a future, definitive, multicenter trial evaluating the effect of bag- mask ventilation on hypoxemia, aspiration, and clinical outcomes.

PI_NAMEs: CASEY, JONATHAN DALE (contact)

PROGRAM_OFFICER_NAME: KALANTARI, ROYA

PROJECT_TERMS: Academic Medical Centers;Accident and Emergency department;Active Learning;Acute Respiratory Distress Syndrome;Address;Adult;Adverse event;Affect;Anesthesia procedures;aspirate;Award;Benefits and Risks;Bioinformatics;Biometry;Calibration;career;career development;Caring;Characteristics;Clinical;Clinical Research;Clinical Trials;comparative effectiveness trial;Complication;Consent Forms;Critical Illness;Data;Databases;design;Development;Development Plans;Devices;efficacy outcomes;Emergency research;endotracheal;Environment;Exclusion;experience;Fasting;Fostering;Functional disorder;Funding;Future;Goals;Heart Arrest;Heterogeneity;high risk;human subject protection;Hypoxemia;implementation science;implementation tool;improved;Incidence;Inflammatory;Informed Consent;Institution;Insufflation;Intensive Care Units;International;Intervention;Intervention Trial;Intratracheal Intubation;Intubation;Journals;K-Series Research Career Programs;Knowledge;Laryngoscopy;Learning;Life;Linear Models;Lung;lung injury;Maintenance;Manuals;Masks;Mechanical ventilation;Medicine;Mentors;Methodology;Methods;Modeling;Multicenter Trials;New England;Outcome;Oxygen;Oxygen Therapy Care;participant enrollment;patient population;patient safety;Patient-Focused Outcomes;Patients;Phase;Physicians;pragmatic trial;Pre-hospital setting;Predisposition;prevent;professor;prognostic;prognostic model;Publishing;randomized trial;Research;Research Project Grants;Resources;respiratory;Respiratory Failure;Risk;risk/benefit ratio;Safety;Scientist;Statistical Methods;Stomach;Techniques;Testing;Time;tool;Training;treatment as usual;treatment effect;Tube;United States;United States National Institutes of Health;ventilation;Weaning

PROJECT_TITLE: Bag-Mask Ventilation to PreVent Hypoxemia during Tracheal Intubation in the Emergency Department: A Clinical Trial

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(MA)]


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Asthma;Basic Behavioral and Social Science;Behavioral and Social Science;Childhood Obesity;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Neurosciences;Obesity;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: PROVIDENCE

ORG_NAME: RHODE ISLAND HOSPITAL

ORG_STATE: RI

PHR: PROJECT NARRATIVE This research seeks to characterize the evolving dynamic relationships between childhood asthma, obesity, and neurodevelopmental outcomes, and the influencing and moderating factors that act that the child, family, and neighborhood levels. Taking an unbiased and intentional approach towards inclusivity, we will use innovative remote data collection and mobile labs to engage traditionally under-represented families and communities, and collect rich multi-level child health, neurodevelopment, and important contextual social, socioeconomic, and social inequity data. Leveraging the ECHO Cohort, and our own Cohort Study Site, we will take a team science approach to identify periods of peak risk and key moderating factors that impact child weight, asthma, and cognitive development, to improve health outcomes for all children.

PI_NAMEs: D'SA, VIREN ANDREW;KOINIS MITCHELL, DAPHNE  (contact);MUELLER, HANS-GEORG

PROGRAM_OFFICER_NAME: MASH, CLAY

PROJECT_TERMS: Acceleration;Accounting;Address;Adherence;Adolescence;Affect;Anthropometry;Area;Asthma;Behavior;Behavioral;Biological;Birth;Characteristics;Chemical Exposure;Chemicals;Child;Child Development;Child Health;Childhood;Childhood Asthma;Cognitive;cognitive ability;cognitive development;cognitive function;cognitive skill;cognitive testing;cohort;Cohort Analysis;Cohort Studies;Collaborations;Collection;Communities;Complex;Conceptions;COVID-19 pandemic;Data;Data Collection;data quality;Diet;Dimensions;Disadvantaged;Discrimination;Disparity;Disparity population;early life exposure;economic disparity;Economics;Education;educationally disadvantaged;Elements;Enrollment;Ensure;Environmental Exposure;Environmental Risk Factor;ethnic minority;Ethnic Origin;Evidence based intervention;executive function;experience;Face;Family;Feedback;Genetic;Genetic Risk;Guidelines;Health;health disparity;Home;improved;Individual;Inequality;Inequity;innovation;Intervention;Knowledge;Life;Light;Link;Lived experience;Low income;Masks;Maternal Health;Measures;mindfulness;Minority;Nature;neighborhood safety;Neighborhoods;neurodevelopment;novel;Obesity;obesity in children;Outcome;pandemic disease;Parents;Participant;Pathway interactions;Physical activity;physical conditioning;Policies;pollutant;postnatal;prenatal;prenatal exposure;Process;psychosocial;Public Health;public health research;Public Policy;Race;racial minority;Recovery;Research;Research Personnel;residential segregation;response;Rhode Island;Risk;Sample Size;Schools;Science;Shapes;Site;Sleep;social;social disparities;social health determinants;sociodemographics;socioeconomics;Spanish/English;Spirometry;Statistical Models;Talents;Testing;Time;Visit;Weight

PROJECT_TITLE: ASSESSING THE EVOLVING IMPACT OF EARLY LIFE EXPOSURES ON CHILD PHYSICAL HEALTH AND NEURODEVELOPMENT

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-EPH-S(50)R]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Biotechnology;Cancer;Cervical Cancer;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Infectious Diseases;Prevention;Rare Diseases;Women's Health Research

ORG_CITY: TEMPE

ORG_DEPT: MISCELLANEOUS

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

ORG_STATE: AZ

PHR: Project Narrative/Relevance Measuring the strength of patient antibody responses in clinical samples is important in cancer biology and diagnostics. We propose to develop an innovative high-throughput platform, in which we will marry the powerful DNA sequencing technology and immunoassay to assess antibody response to many hundreds of cancer related pathogens in many thousands of individuals simultaneously. This will create a fast, sensitive, low cost, robust research tool for early screening of pathogen induced cancers.

PI_NAMEs: LABAER, JOSHUA  (contact)

PROGRAM_OFFICER_NAME: WANG, WENDY

PROJECT_TERMS: 2019-nCoV;Agreement;anti-cancer research;Antibodies;Antibody Response;antibody test;Antigens;Autoimmune Diseases;Automation;Bacteria;Bar Codes;Benchmarking;Binding;Binding Proteins;Biological Assay;Cancer Biology;Cancer Burden;Cancer Diagnostics;Cancer Patient;carcinogenesis;Cervical Squamous Cell Carcinoma;Characteristics;Clinic;Clinical;co-infection;Communicable Diseases;comparison control;Competence;Consumption;cost;COVID-19 assay;COVID-19 diagnosis;COVID-19 pandemic;COVID-19 patient;Data;data pipeline;Detection;detection limit;detection method;Development;Diagnosis;Diagnostic tests;Disease;Disease Progression;DNA;DNA Sequence;DNA sequencing;early screening;Educational process of instructing;Enzyme-Linked Immunosorbent Assay;Epidemiology;Epitopes;Etiology;experience;FDA Emergency Use Authorization;Fluorescence;fungus;Head and Neck Squamous Cell Carcinoma;Head and neck structure;Hepatitis C;Heterogeneity;Human;Human Herpesvirus 4;Human Papillomavirus;Immune response;Immunoassay;improved;indexing;Individual;Informatics;innovation;Kinetics;Laboratories;large scale production;Legal patent;Length;Libraries;Liquid substance;Malignant neoplasm of cervix uteri;Malignant Neoplasms;malignant oropharynx neoplasm;Measurement;Measures;Methods;microbial;microorganism;microorganism antigen;Monitor;multiplex assay;next generation;next generation sequencing;Noise;Oropharyngeal;Oropharyngeal Squamous Cell Carcinoma;pathogen;Patients;Peptides;Performance;Phase;Play;Preparation;Procedures;process optimization;Production;programs;Protein Array;Protein Array Analysis;protein folding;Protein Microchips;Proteins;Proteome;Protocols documentation;Quality Control;Reagent;Reproducibility;Research;respiratory pathogen;response;Risk Assessment;Running;Sampling;SARS-CoV-2 antibody;screening;Screening for cancer;seasonal coronavirus;Serology test;Serum;Signal Transduction;Surface;Technology;Testing;tool;Tumor Antigens;Variant;Viral Antigens;Virus

PROJECT_TITLE: Multiplex In-Solution Protein Array (MISPA) for high throughput, quantitative, early profiling of pathogen-induced head and neck


ORG_CITY: MEMPHIS

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

PHR: NARRATIVE Immunotherapy is a promising treatment for pediatric cancer that can improve outcomes while minimizing toxicity and the long-term adverse effects associated with other types of therapy. The success of this treatment requires more discovery-based researchers who aim to improve understanding of how pediatric cancer cells interact with the immune system, and translational researchers to refine immunotherapeutic approaches for use in early phase clinical studies. The Pediatric Immuno-Oncology and Immunotherapy training program is designed to provide integrated training in advanced research approaches in a clinical context to foster the development of the next generation of independent scientists leading the field.

PI_NAMEs: GOTTSCHALK, STEPHEN  (contact)

PROJECT_TITLE: T32 Training Program in Pediatric Immuno-Oncology and Immunotherapy


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics

ORG_CITY: Columbus

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE Protein synthesis is essential in all domains of life. Our recent work has shown that deviations from the canonical model of translation are frequent and directly cause to human disease. This research program seeks to mechanistically define how non-canonical initiation and regulation occurs.

PI_NAMEs: KEARSE, MICHAEL G (contact)

PROGRAM_OFFICER_NAME: VATAKIS, DIMITRIOS NIKOLAOS

PROJECT_TERMS: Address;Amino Acyl Transfer RNA;Apoptosis;Cells;Code;Disease;Genome;Goals;Human;human disease;Initiator Codon;Lead;Life;Messenger RNA;Mutation;neurotoxic;Pathology;Peptide Initiation Factors;programs;Protein Biosynthesis;Proteins;Regulation;Research;Ribosomes;RNA Recognition Motif;sensor;spatiotemporal;Translating;Translation Initiation;translational model;Translational Regulation;Translations;Work

PROJECT_TITLE: Non-canonical mechanisms of translation initiation and regulation

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Lung;Neurodegenerative;Neurosciences;Prevention;Sleep Research;Women's Health Research

ORG_NAME: CALIFORNIA PACIFIC MED CTR RES INSTITUTE

PHR: The prevalence of Alzheimer disease (AD) is high and projected to increase. Obstructive sleep apnea (OSA) is common among the elderly (30-55%), and we and others have shown that older adults with OSA are at increased risk for dementia and AD. We propose a novel and flexible approach to treating OSA in cognitively normal older adults, and will test whether those successfully treated for OSA have slower decline in cognitive function, and improved AD biomarkers (measured in blood) compared to those who are untreated.

PI_NAMEs: OSORIO, RICARDO S;STONE, KATIE L (contact);VARGA, ANDREW W

PROGRAM_OFFICER_NAME: HETTINGER, JANE CECELIA

PROJECT_TERMS: actigraphy;Acute;Address;Adherence;advanced disease;Age;Alzheimer's Disease;Alzheimer's disease risk;Alzheimer’s disease biomarker;Amyloid;Amyloid beta-Protein;Apnea;arm;Biological Markers;Blood;Clinic;Clinical;Clinical Treatment;Cognition;Cognitive;cognitive change;cognitive function;cognitive testing;Control Groups;Data;Dementia;dementia risk;Diagnosis;Disease Progression;Early identification;effective therapy;Effectiveness;Elderly;Elderly woman;epidemiologic data;Evaluation;experience;Face;flexibility;Future;Hypoxemia;Impaired cognition;improved;indexing;Individual;innovation;Intention;Intervention;Light;Link;Liquid substance;Measures;Memory;mild cognitive impairment;modifiable risk;nerve injury;neurofilament;Newly Diagnosed;novel;Obstructive Sleep Apnea;older adult;older women;open label;Oral Positive Airway Pressure;Outcome;Participant;Patient Self-Report;Patients;Phase;Plasma;positive airway pressure;pre-clinical;Prevalence;Prevention strategy;Protocols documentation;Randomized;randomized trial;Randomized, Controlled Trials;recruit;Reporting;Risk;Severities;Sleep;Sleep Disorders;Sleep disturbances;Slow-Wave Sleep;specific biomarkers;Target Populations;tau Proteins;tau-1;Testing;treatment effect;treatment group;trend;Waiting Lists;Withdrawal;Work

PROJECT_TITLE: Effects of Successful OSA TreatmENT on Memory and AD BIomarkers in Older AduLts (ESSENTIAL)

STUDY_SECTION: LHB

STUDY_SECTION_NAME: Lifestyle and Health Behaviors Study Section[LHB]


NIH_SPENDING_CATS: Cancer;Clinical Research;Digestive Diseases;Esophageal Cancer;Genetic Testing;Genetics;Orphan Drug;Precision Medicine;Prevention;Rare Diseases

ORG_CITY: CLEVELAND

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

PHR: Project Narrative Interception of esophageal adenocarcinoma (EAC) by eradication dysplasia when detected in its precursor Barrett’s esophagus (BE) is required for a cancer whose rate has more than sextupled in the past three decades. Biomarkers that can a) effectively identify dysplasia and risk-stratify patients with BE who are at risk for progression to cancer and those who are not; and b) effectively identify those who are likely to recur after successful ablative therapy for dysplastic BE and those who are not will prevent unnecessary ablative therapy and minimize costs by decreasing the frequency of endoscopy after successful ablative therapy.

PI_NAMEs: BETTEGOWDA, CHETAN ;CHAK, AMITABH ;MARKOWITZ, SANFORD D. (contact);SHAHEEN, NICHOLAS J;WANI, SACHIN ;WILLIS, JOSEPH EDWARD

PROGRAM_OFFICER_NAME: YOUNG, MATTHEW R

PROJECT_TERMS: Aberrant DNA Methylation;Ablation;Algorithms;Aneuploidy;Award;Barrett Esophagus;biobank;Biological Assay;Biological Markers;biomarker panel;biomarker performance;biomarker validation;Biopsy;Breakthrough device;Cessation of life;Chromosomes;Classification;Clinical;commercialization;Complication;cost;Detection;Devices;Diagnosis;Diagnostic;digital imaging;Disease;Disease Progression;Disease remission;disorder risk;Distal;DNA;DNA analysis;DNA Markers;DNA Methylation;Dysplasia;Early Detection Research Network;Early Diagnosis;Effectiveness;Endoscopy;Enrollment;epigenetic marker;Esophageal Adenocarcinoma;Esophageal Neoplasms;Esophagectomy;Esophagus;Excision;Face;falls;FDA approved;follow-up;Frequencies;Future;Guidelines;High grade dysplasia;high risk;Histology;Image;Immunohistochemistry;Incidence;Individual;Intestinal Metaplasia;Laboratories;Lesion;liquid biopsy;Longitudinal Studies;Malignant neoplasm of esophagus;Malignant Neoplasms;Medical;Methods;Methylation;Molecular;molecular marker;Morbidity - disease rate;mortality;Natural History;neoplastic;new epidemic;next generation sequencing;North Carolina;overtreatment;Pathologist;patient stratification;patient subsets;Patients;Periodicals;Phase;phase 3 study;phase 4 study;predictive marker;premalignant;prevent;Prevention;progression risk;prospective;Prospective Studies;Publishing;Recommendation;Recording of previous events;Recurrence;Recurrent disease;Residual Neoplasm;Retrospective Studies;Risk;risk stratification;Role;routine practice;Sampling;Societies;Squamous Epithelium;surveillance study;Technology;Testing;Tissues;TP53 gene;Universities;Validation;validation studies;Vimentin

PROJECT_TITLE: Validation of Biomarkers for predicting Barrett's esophagus that will or will not: i) progress towards cancer, or ii) recur after ablation


ADMINISTERING_IC: AI

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Coronaviruses;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Infectious Diseases;Nanotechnology;Prevention;Vaccine Related

ORG_DEPT: ENGINEERING (ALL TYPES)

PHR: PROJECT NARRATIVE  Although vaccines have been effective at protecting against infectious diseases that pose serious threats to human health, they can also be limited when variants of the pathogen emerge, yielding lower neutralization efficacy, and requiring booster immunizations – consequences which are observed in the current COVID-19 global pandemic. This work aims to redesign conventional vaccines using hydrogels to improve their durability and breadth of immune response. Ultimately, successful implementation of this approach could provide a more effective immune response to the SARS-CoV-2 virus and its emerging variants and provide a general vaccine design strategy that could have broader applicability toward other infectious pathogens.

PI_NAMEs: WANG, SZU-WEN  (contact)

PROGRAM_OFFICER_NAME: GORDON, JENNIFER L

PROJECT_TERMS: 2019-nCoV;Adjuvant;Antibodies;Antibody Formation;Antibody Response;Antibody titer measurement;Antigen Presentation;Antigens;biodegradable polymer;Biological Assay;Bolus Infusion;Cells;Communicable Diseases;controlled release;Coronavirus;COVID-19 pandemic;COVID-19 vaccine;cross reactivity;cytokine;design;efficacy evaluation;emerging pathogen;Encapsulated;Epitopes;Exposure to;Formulation;Health;Histologic;Human;Hydrogels;Immune;Immune response;Immunity;Immunization;improved;In Vitro;in vivo;in vivo imaging system;Individual;Influenza;Injections;Kinetics;Libraries;Malignant Neoplasms;Measures;Mediating;Mus;nanolabel;nanoparticle;nanovaccine;Nature;neutralizing antibody;pandemic disease;particle;pathogen;Physiological;Polymers;Preventive vaccine;Protein Array;Protein Engineering;Proteins;receptor;receptor binding;response;SARS-CoV-2 variant;Secondary Immunization;Serum;Site;Surface;synergism;System;T cell response;T-Lymphocyte;Temperature;Testing;Time;Transition Temperature;Vaccination;vaccine delivery;Vaccine Design;vaccine development;vaccine effectiveness;vaccine formulation;vaccine immunogenicity;vaccine strategy;Vaccines;Variant;Viral;Virus;Work

PROJECT_TITLE: Improving the Immune Response to Nanoparticle-Based SARS-CoV-2 Vaccines

STUDY_SECTION: GDD

STUDY_SECTION_NAME: Gene and Drug Delivery Systems Study Section[GDD]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Dissemination and Implementation Research;HIV/AIDS;Health Services;Infectious Diseases;Prevention;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

PHR: Narrative There is an urgent need to adapt and implement effective tobacco cessation interventions in HIV care programs in low- and middle-income settings. This study will evaluate the effectiveness and cost-effectiveness of an integrated varenicline and mobile behavioral intervention among smokers and dual tobacco users in HIV care in Chennai, India. Combining a scalable mobile health intervention with cost-effective pharmacotherapy could reduce the harmful impacts of tobacco among people living with HIV.

PI_NAMEs: KRUSE, GINA RAE (contact)

PROGRAM_OFFICER_NAME: CORREA-MENDEZ, MARGARITA

PROJECT_TERMS: Abstinence;Adherence;Adoption;Adult;antiretroviral therapy;Behavior Therapy;Behavioral;bidis;Biochemical;brief advice;care systems;Caring;Cellular Phone;Cigarette;Clinical;clinical research site;Clinical Treatment;Collaborations;Communicable Diseases;comparison intervention;cost;cost effective;cost effectiveness;Cost Effectiveness Analysis;Cost Measures;Data;design;effective therapy;Effectiveness;effectiveness evaluation;effectiveness study;effectiveness testing;Epidemic;health communication;Health Services;HIV;Home;hookah;implementation evaluation;implementation process;implementation strategy;Income;India;Individual;interest;International;Intervention;low and middle-income countries;Measures;Medical center;medication compliance;mHealth;mhealth interventions;Modeling;models and simulation;novel;open label;Outcome;Patients;Penetration;Persons;Pharmaceutical Preparations;Pharmacotherapy;Population;Positioning Attribute;Proctor framework;programs;Provider;quitline;Randomized;randomized trial;randomized, clinical trials;Reporting;Research;Research Personnel;Resources;Safety;scale up;Self Efficacy;Site;Smoke;Smokeless;Smokeless Tobacco;smokeless tobacco cessation;smokeless tobacco use;Smoker;Smoking;smoking prevalence;social cognitive theory;stakeholder perspectives;standard care;success;Testing;theories;timeline;Tobacco;tobacco abstinence;tobacco cessation intervention;tobacco control;Tobacco Dependence;Tobacco smoke;tobacco smokers;Tobacco use;Tobacco Use Cessation;tobacco user;treatment program;two-arm trial;varenicline;Viral;Work;years of life lost

PROJECT_TITLE: Varenicline and mobile behavioral assistance for tobacco cessation in HIV care in India


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: RONDEBOSCH

ORG_COUNTRY: SOUTH AFRICA

ORG_FIPS: SF

ORG_NAME: UNIVERSITY OF CAPE TOWN

PHR: NARRATIVE The burden of bacterial infectious disease in sub-Saharan Africa (SSA) is considerable and increasing at an alarming rate due to factors that are both different from and/or amplifications of those found in high income countries. A research training program leveraging and transferring the University of California Davis (UCD) unrivaled strengths in animal modeling of bacterial infection to generate a center of excellence in pre-clinical bacterial infection biology at the University of Cape Town (UCT), is urgently needed to establish pre-clinical research capacity to complement existing clinical research and, ultimately, tackle the key research needs required for regional control of devastating bacterial infections. A Fogarty research training program at UCT will allow us to train the next generation of researchers to acquire the advanced understanding and associated laboratory skills needed to develop animal models of bacterial infections of enormous local impact.

PI_NAMEs: HORSNELL, WILLIAM  (contact)

PROGRAM_OFFICER_NAME: SINA, BARBARA J

PROJECT_TERMS: Acceleration;Africa South of the Sahara;animal facility;Animal Model;Antimicrobial Resistance;Bacterial Infections;biological research;Biology;California;Clinical Research;Communicable Diseases;Complement;Development;Disease;disease model;Ethics;Exclusion;Grant;Home;Human;Immunity;in vivo;Infection;infectious disease model;Infectious Diseases Research;International;Klebsiella pneumoniae;mortality;Mus;Mycobacterium tuberculosis;pathogen;Pathogenesis;pathogenic bacteria;pre-doctoral;prevent;Primates;Process;programs;Public Health;Reagent;Research;Research Personnel;Research Training;Resources;Salmonella enterica;South Africa;Streptococcus pneumoniae;symposium;Training;Training Programs;Universities;Vaccines;Veterinary Schools;Virulence;Work

PROJECT_TITLE: Developing an in vivo infectious disease training program at the University of Cape Town

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DCAI-B(55)]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Nutrition;Prevention;Rural Health;Social Determinants of Health

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative Older adults in rural communities disproportionately experience food and nutrition insecurity, which may contribute to urban/rural disparities in cardiovascular disease outcomes. The emergency food system, particularly food pantries, serve as a safety net for rural older adults who are ineligible for or underserved by government food assistance programs, but there are barriers to accessing this resource and it is particularly underutilized by older adults and in non-metropolitan areas. By co-producing research with stakeholders in the emergency food system and rural older adults, findings from this proposed project will inform interventions in the emergency food system to enhance food and nutrition security, improve dietary intake, and benefit rural older adults with cardiovascular disease.

PI_NAMEs: BRADY, PATRICK J. (contact)

PROGRAM_OFFICER_NAME: TORRES, DELANY

PROJECT_TERMS: Address;Adult;adult nutrition;Aging;Area;Award;burden of illness;Cardiovascular Diseases;career;Chronic Disease;Client;Communities;community engaged approach;community engaged research;Conceptions;Coronary heart disease;County;COVID-19 pandemic;Data;Data Collection;design;Diet;Dietary Assessment;Dietary intake;disease disparity;Disease Outcome;Disparity;effectiveness evaluation;Emergency Situation;Environment;environmental change;environmental intervention;Equity;Evaluation;experience;Food;Food Access;Food Assistance Programs;food quality;Foundations;Goals;good diet;Government;Health;health care availability;Health Food;Health Services Accessibility;healthy aging;Hour;Household;human centered design;implementation intervention;improved;Individual;Intervention;Intervention Studies;Interview;Lead;Low income;Mentors;Mentorship;Methods;metropolitan;Minnesota;nonmetropolitan area;novel;nutrition;Nutrition Assessment;Nutritional;Nutritional Study;older adult;operation;Pathway interactions;Phase;pilot test;Policies;Population;population survey;Preparation;Prevalence;Prevention Measures;Preventive measure;Process;programs;Qualitative Research;Recording of previous events;Research;Research Methodology;Research Personnel;Resources;Risk;Role;Rural;rural area;Rural Community;rural counties;rural disparities;rural dwellers;Rural Population;rural underserved;safety net;Sampling;Security;Site;social health determinants;Strategic Planning;success;Surveys;System;Testing;therapy design;therapy development;tool;Training;Transportation;United States National Institutes of Health;Universities;urban disparity;volunteer;Work

PROJECT_TITLE: Addressing Rural Disparities in Food and Nutrition Security and Cardiovascular Diseases Through Access to Emergency Food for Older Adults

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development Facilitating The Transition to Independence Study Section[AGCD-1]


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Dietary Supplements;Digestive Diseases;HIV/AIDS;Infectious Diseases;Liver Disease;Microbiome;Nutrition

PHR: Narrative Persons with human immunodeficiency virus (HIV) have higher risk of developing fatty liver disease (NAFLD) than HIV-negative persons but the reasons for this discrepancy are not known. Changes in the intestinal microbiome may contribute to the development of NAFLD in persons with HIV (PWH) through impairment of barrier function of the intestinal wall and by producing metabolites that are harmful to the liver. This project will test the hypothesis that HIV-related NAFLD is associated with differences in the intestinal microbiome and that supplementation with probiotic and prebiotic fiber will lead to improvements in markers of NAFLD in PWH.

PI_NAMEs: GABRIEL, CURTIS LEE (contact)

PROJECT_TERMS: Academic Medical Centers;Acquired Immunodeficiency Syndrome;Address;Adipose tissue;Aging;AIDS clinical trial group;Alcohol abuse;Alcohol consumption;Alcohols;Amines;antiretroviral therapy;Bacteria;bacterial community;Biological Markers;Butyrates;cardiometabolism;Cardiovascular system;career;career development;Clinical;Clinical Research;Clinical Trials;co-infection;cohort;Cohort Studies;comorbidity;Data;Deposition;design;Development;Diagnostic;Disparity;dysbiosis;Enrollment;Environment;Evaluation;Fatty Liver;fatty liver disease;feasibility testing;Fiber;Foundations;Functional disorder;Funding;Goals;Grant;gut bacteria;gut microbiome;gut-liver axis;Health;Heavy Drinking;Hepatic;high risk;HIV;HIV Infections;HIV Seronegativity;imaging study;Immunology;Impairment;improved;Inflammatory;Infrastructure;intestinal barrier;Intestines;Lead;Leaky Gut;Lecithin;Link;Lipids;Liver;Liver diseases;Mass Spectrum Analysis;Measures;Mentored Clinical Scientist Development Program;Mentors;metabolic fitness;Metabolism;metabolome;metabolomics;microbiome;microbiome composition;microbiome research;mortality;multidisciplinary;non-alcoholic fatty liver disease;Oxides;Participant;Pathogenesis;Patients;Persons;pilot trial;Plasma;prebiotics;prevent;probiotic supplementation;Probiotics;prospective;Publications;Recording of previous events;recruit;Research;Research Infrastructure;Research Personnel;Resources;Sampling Studies;Scientist;secondary analysis;Specimen;Strategic Planning;Tennessee;Testing;Training;United States National Institutes of Health;Universities;Veterans;Viral hepatitis;Viremia

PROJECT_TITLE: The Gut-Liver Axis in HIV-Related Non-Alcoholic Fatty Liver Disease

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

ORG_CITY: MADISON

ORG_DEPT: NUTRITION

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE A large number of bacterial species produce a small molecule called c-di-AMP that regulates bacterial growth, stress response, and adaptation. This project investigates the mechanisms underlying these regulations in different bacteria. Our findings will facilitate the development of novel genetic engineering and antibacterial strategies.

PI_NAMEs: HUYNH, TU ANH  (contact)

PROGRAM_OFFICER_NAME: RIGAS, MARC

PROJECT_TERMS: Anti-Bacterial Agents;Bacteria;Biochemical;biological adaptation to stress;Biological Assay;Biological Process;Cells;Defect;Detection;Development;Firmicutes;fitness;Genetic;Genetic Engineering;Growth;Homeostasis;Hydrolysis;Laboratories;Laboratory Finding;Molecular Target;mutant;novel;Nucleotides;Pathway interactions;Phenotype;phosphoric diester hydrolase;Physiology;Regulation;Role;Second Messenger Systems;Signal Transduction;small molecule;Toxic effect

PROJECT_TITLE: The regulation of c-di-AMP homeostasis and signaling in bacteria

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-GGG-X(55)R]


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Cancer;Pediatric;Prevention

ORG_CITY: HOUSTON

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: UPWARDS Training Program Public Health Relevance Statement/Project Narrative As a recognized leader in cancer research, MD Anderson Cancer Center is well poised to address the critical lack of diversity plaguing the cancer research workforce and educational pipeline via early intervention programs that foster sustained interest in cancer research for young scientists. Our comprehensive UPWARDS Training Program (Underrepresented Minorities Working Towards Research Diversity in Science) addresses major barriers deterring and preventing many minority students from pursuing and succeeding in graduate programs and in cancer research careers. The UPWARDS Training Program will cultivate high school and undergraduate minority scientists with the goal of increasing diversity in biomedical graduate programs and in the cancer research workforce through 1) minority-focused recruitment, 2) hands-on cancer research experiences, 3) a strong mentoring and career/professional development, 4) education and engagement of minority communities and younger generations in the STEM pipeline through outreach and community education activities, and 5) a rigorous assessment plan with dissemination of best practices.

PI_NAMEs: KEYOMARSI, KHANDAN  (contact);WATOWICH, STEPHANIE S

PROGRAM_OFFICER_NAME: CALZOLA, JESSICA MARIE

PROJECT_TERMS: Address;Admission activity;anti-cancer research;Bachelor's Degree;Bioethics;Cancer Biology;cancer care;Cancer Center;cancer health disparity;cancer prevention;career;career awareness;Career Choice;career development;Career Exploration;Childhood;Communication;Communities;Community Health Education;Community Outreach;Data;design;Development;Development Plans;Disparity;Doctor's Degree;Early Intervention;Economics;Education;education research;Educational Activities;Educational process of instructing;Enrollment;experience;Exposure to;Faculty;faculty mentor;Family;Feedback;Fostering;Generations;Goals;Graduate Education;hands on research;Healthcare;high school;high school program;High School Student;Individual;innovation;interest;intervention program;Knowledge;Laboratory Research;Lead;Learning;Mentors;Minority;minority communities;minority engagement;minority scientist;minority student;minority undergraduate;Mission;novel;Oral;Outcome;outreach;Peer Review;Positioning Attribute;posters;prevent;Prevention education;Process;programs;public health relevance;Publications;recruit;recruitment science;Research;Research Training;responsible research conduct;Role;Science;Science, Technology, Engineering and Mathematics Education;Scientist;skill acquisition;skills;STEM career;student training;Students;success;summer research;Support System;Time;Training;Training Programs;undergraduate student;Underrepresented Minority;Underrepresented Students


ORG_CITY: LOS ANGELES

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE The major goal of the proposed project is to evaluate the role of UCHL1 in aggressive prostate cancer. The study will also define novel mechanisms through which UCHL1 contributes to the development of the advanced disease. Completion of the proposed research will give us insights into new mechanisms underlying the development of aggressive prostate cancer and open novel avenues for therapeutic intervention.

PI_NAMEs: STOYANOVA, TANYA I (contact)

PROGRAM_OFFICER_NAME: SNYDERWINE, ELIZABETH G

PROJECT_TERMS: Advanced Development;advanced disease;advanced prostate cancer;Aggressive Clinical Course;aggressive therapy;androgen deprivation therapy;androgen independent prostate cancer;Androgens;Animal Model;Biological Assay;Biological Models;Biotin;Cancer Etiology;Castration;Cell Line;Cells;Cessation of life;combat;Development;Disease;Down-Regulation;Goals;Growth;hormone therapy;Human;Incidence;inhibitor;insight;Life Expectancy;Malignant neoplasm of prostate;Mass Spectrum Analysis;Mediating;men;Metastatic Prostate Cancer;Modeling;Molecular;mortality;Neoplasm Metastasis;neuroendocrine phenotype;Neurosecretory Systems;novel;novel therapeutic intervention;overexpression;Pathway interactions;patient derived xenograft model;Patients;Peptide Hydrolases;pre-clinical;preclinical study;prostate cancer cell line;prostate cancer metastasis;prostate cancer model;protein degradation;Proteins;Proteome;Proteomics;Recurrence;Regulation;Relapse;Research;Resistance;response;Role;Sampling;Series;Signal Transduction;Study Section;Testing;Therapeutic;therapeutic candidate;therapeutic evaluation;Therapeutic Intervention;therapeutic target;therapy resistant;Time;tumor;tumor growth;Ubiquitin;ubiquitin C-terminal hydrolase;UCHL1 gene;UCHL1 protein;United States;Xenograft Model

PROJECT_TITLE: Elucidating the Role of UCHL1 in Aggressive Prostate Cancer

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 2 Study Section[MCT2]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Child Abuse and Neglect Research;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Pediatric;Prevention;Social Determinants of Health;Violence Research

ORG_CITY: BLOOMINGTON

ORG_NAME: CHESTNUT HEALTH SYSTEMS, INC.

ORG_STATE: IL

PHR: PROJECT NARRATIVE This proposal responds to NIMH Objective 4.2.c to develop “decision-support tools and technologies that increase the effectiveness and continuous improvement of mental health interventions” by leveraging the Family First Prevention Services Act (FFPSA) policy opportunity. First, a web-based platform to host (a) a decision-support tool and (b) automated facilitation for group decisions with the tool will be developed with state partners’ feedback. Next, decision makers leading their states’ FFPSA quality improvement efforts will be engaged to pilot a decision-support intervention comprised of the tool and live or automated facilitation, and to evaluate the implementation quality of evidence-based programs adopted with the decision-support intervention.

PI_NAMEs: CRUDEN, GRACELYN  (contact)

PROGRAM_OFFICER_NAME: SIMS, BELINDA ENITA

PROJECT_TERMS: Adopted;Adoption;advanced simulation;Assessment tool;Authorization documentation;automated assessment;Characteristics;Child;Child Abuse and Neglect;Child Mental Health;Child Rearing;Child Support;Child Welfare;Collaborations;community engagement;Data;Decision Analysis;Decision Making;Development;Effectiveness;Evaluation;Evidence based program;experience;Family;Family Study;federal policy;Feedback;foster care;Foundations;Funding;Goals;implementation evaluation;implementation measures;implementation process;implementation strategy;implementation study;improved;Individual;individual response;informant;innovation;interdisciplinary approach;Interdisciplinary Study;Intervention;Interview;K-Series Research Career Programs;Lead;Longitudinal Studies;Manuals;Measures;member;Mental Health;Mentors;Methods;Modality;model building;models and simulation;Monitor;National Institute of Mental Health;Online Systems;Outcome;Parents;Personal Satisfaction;pilot test;Policies;preference;prevent;prevention service;Process;Public Health;Randomized;Records;Research Activity;Research Training;Resources;response;Risk;Science;Services;skills;social;statistics;Structure;Substance abuse problem;substance misuse;support tools;System;Technology;Testing;Time;timeline;tool;Training Activity;United States;user centered design;user-friendly;wasting;web platform;Work

PROJECT_TITLE: Refining and Pilot Testing a Decision Support Intervention to Facilitate Adoption of Evidence-Based Programs to Improve Parent and Child Mental Health

STUDY_SECTION: SERV

STUDY_SECTION_NAME: Mental Health Services Study Section[SERV]


ORG_CITY: PITTSBURGH

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project Narrative Over 10 million Americans have peripheral arterial disease, a disease that, if left untreated, leads to amputation. Current treatment options for peripheral arterial disease fail up to 50% of the time within two years. This proposal seeks to develop and begin the commercialization of a novel and more robust treatment for this devastating disease.

PI_NAMEs: VANDE GEEST, JONATHAN PIETER (contact)

PROGRAM_OFFICER_NAME: THAKAR, RAHUL GAUTAM

PROJECT_TERMS: Acceleration;advanced disease;American;Amputation;Anatomy;Angioplasty;arterial tortuosity;Arteries;Award;Balloon Angioplasty;Blood Platelets;Blood Vessels;Body Temperature;Businesses;Bypass;Catheters;Clinical;clinical translation;Clinical Treatment;commercialization;Complex;critical limb Ischemia;design;Devices;Disease;Equipment Malfunction;Exercise;Failure;Family suidae;femoral artery;Fracture;Funding;Future;Goals;Grant;Histology;Human Resources;Image;Immune response;improved;In Situ;In Vitro;in vivo;Intervention;Investments;Joints;Knee;Left;Legal patent;Lesion;Lower Extremity;Marketing;Mechanical Stress;Mechanics;Modeling;Morbidity - disease rate;Motion;next generation;novel;Operative Surgical Procedures;Outcome;Patients;Performance;Peripheral;Peripheral arterial disease;Pharmaceutical Preparations;Phase;Proteins;prototype;Radial;Research;response;restenosis;Risk;scaffold;Shapes;smoking cessation;standard care;Stents;Stress;stress state;Structure of popliteal artery;Symptoms;Technology;technology platform;Temperature;Time;timeline;Translating;Treaty;two-dimensional;vascular injury

PROJECT_TITLE: Biocarpet: The Next Generation Endovascular Device for Peripheral Arterial Disease


ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE Chronic kidney disease (CKD) and Acute Kidney Injury (AKI) remain a major health problem that causes substantial disability and premature death. The University of Michigan George M. O'Brien Kidney Translational Resource Center will provide researchers the opportunity to utilize advanced technologies by providing the necessary infrastructure and tools to improve care of patients with AKI and CKD. Through its research cores, enrichment activities, and community outreach, it will serve as a national resource for enabling new discoveries and enhance scientific progress supporting cutting-edge basic, clinical and translational kidney research.

PI_NAMEs: PENNATHUR, SUBRAMANIAM  (contact)

PROGRAM_OFFICER_NAME: SCHULMAN, IVONNE HERNANDEZ

PROJECT_TERMS: Acute;Acute Renal Failure with Renal Papillary Necrosis;Area;base;Basic Science;bench to bedside;Big Data;Bioinformatics;Biological;Biological Markers;Biological Models;biological systems;career;Cessation of life;Chronic Kidney Failure;Clinical;Clinical Research;cohort;Collaborations;Communities;Community Outreach;Complex;Data;Data Analyses;Data Analytics;Data Coordinating Center;data mining;Data Set;Databases;design;Development;Diagnosis;disability;Disease;diversity and equity;Education;effective intervention;effective therapy;End stage renal failure;Ensure;equity, diversity, and inclusion;experience;Faculty;Fostering;Functional disorder;Future;Genetic;Goals;Health;Hematology;high school;Human;Human Resources;improved;Individual;individual patient;Infrastructure;Injury;Injury to Kidney;innovation;interdisciplinary collaboration;Intervention;Kidney;Kidney Diseases;lipidomics;Medicine;metabolomics;Methodology;Michigan;Mission;Modernization;Molecular;mortality;mortality risk;multidimensional data;Multiomic Data;novel;novel diagnostics;novel therapeutics;Online Systems;operation;outreach;outreach program;Pathway interactions;Patient Care;patient oriented;Patients;Physiology;premature;prognostic;Prognostic Marker;programs;Proteomics;Public Health;recruit;Renal function;Research;Research Personnel;research study;Research Training;Resource Development;Resources;Risk;Scientific Advances and Accomplishments;Services;Structure;Students;Surrogate Endpoint;System;Systems Biology;Technology;Therapeutic;tool;transcriptomics;Translational Research;Translations;treatment strategy;undergraduate student;Universities;Urology;user-friendly;Validation;Work

PROJECT_TITLE: University of Michigan O'Brien Kidney Translational Resource Center (MKTC)


NIH_SPENDING_CATS: Kidney Disease

PROJECT_TERMS: Advisory Committees;Advocacy;Advocate;Agreement;base;bench to bedside;Biomedical Research;Collaborations;Collection;college;Communication;Communities;Community Outreach;Consultations;Cost Sharing;Data Analytics;Data Coordinating Center;Decision Making;Dedications;disadvantaged student;Education;educational atmosphere;Effectiveness;Ensure;equity, diversity, and inclusion;Evaluation;Expenditure;Feedback;Funding;Goals;Hematology;improved;Infrastructure;Institution;interdisciplinary approach;Kidney;Leadership;Medical Students;Michigan;National Institute of Diabetes and Digestive and Kidney Diseases;Nature;operation;outreach;Patients;Persons;Process;Productivity;programs;quality assurance;Quality Control;recruit;Reporting;Research;Research Personnel;Research Training;Resource Allocation;Resource Development;Resources;response;Scientist;Services;Social Network;Structure;summer student;Surveys;Systems Biology;Training Programs;Translational Research;Translations;undergraduate student;Underrepresented Students;United States National Institutes of Health;Universities;University adminstration;Urology;web site;working group

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging

ORG_CITY: BUFFALO

ORG_NAME: HAUPTMAN-WOODWARD MEDICAL RESEARCH INST

ORG_STATE: NY

PHR: Project Narrative Structural characterization of biomolecules important in human health and disease is crucial to under- standing how these molecules function, as well as to designing therapeutics. Structural methods that make use of vanishingly small crystals have the potential to revolutionize how we obtain highly detailed structural `snapshots' of biomolecules. This technology development proposal will enable fundamen- tal advances by developing pipelines for enhanced detection, imaging, and sample handling to enable these structural methods, accelerating our understanding of the molecules involved in many diseases and biological processes.

PI_NAMEs: BOWMAN, SARAH ELIZABETH JOHNSON (contact);LYNCH, MIRANDA

PROGRAM_OFFICER_NAME: TAYLOR, VERONICA

PROJECT_TERMS: Acceleration;Acoustics;Address;Algorithms;Binding;Biological;Biological Process;Brightfield Microscopy;Characteristics;Classification;Communities;computerized tools;Coupled;Cryoelectron Microscopy;Crystal Formation;Crystallization;Crystallography;Data;density;Deposition;design;Detection;detection method;Development;Diffusion;Disease;Drug Design;electron diffraction;empowerment;enzyme mechanism;Etiology;experimental study;frontier;Generations;Growth;Health;Human;Image;Image Analysis;image registration;imaging modality;improved;innovation;innovative technologies;Knowledge;Laboratories;Life;Liquid substance;macromolecule;mathematical methods;method development;Methods;Microscopy;Modeling;Molecular;Molecular Structure;molecular targeted therapies;multimodal fusion;Multimodal Imaging;nanocrystal;nanolitre;new therapeutic target;novel;optical imaging;Optics;particle;physical property;Process;Property;protein data bank;Proteins;Research;Research Personnel;Resolution;Sampling;screening;skills;Solvents;Source;Structural Biologist;structural biology;Structural Models;Structure;submicron;Synchrotrons;System;Techniques;Technology;technology development;Testing;Therapeutic;three dimensional structure;Time;tool;Visible Radiation;Visualization;X-Ray Crystallography;X-Ray Medical Imaging

PROJECT_TITLE: New techniques for detecting and handling nanocrystals for cutting edge structural biology methods

STUDY_SECTION: MSFC

STUDY_SECTION_NAME: Macromolecular Structure and Function C Study Section[MSFC]


NIH_SPENDING_CATS: Clinical Research;Data Science;Kidney Disease

PI_NAMEs: KRETZLER, MATTHIAS  (contact)

PROJECT_TERMS: Acute;Address;Advisory Committees;Advocate;analytical tool;Area;Automobile Driving;Back;base;bench to bedside;Biological;Biological Models;biological systems;career development;catalyst;Categories;Chronic Kidney Failure;Clinical;Clinical Trials;Collaborations;Communities;Community Outreach;Core Facility;Critical Pathways;Data Analyses;Data Analytics;data integration;data mining;data modeling;Data Set;data sharing;data visualization;disadvantaged student;Disease;Education;Effectiveness;empowerment;Ensure;equity, diversity, and inclusion;experience;Feedback;Funding;Genetic;genome-wide;Glean;Goals;Grant;Hematology;Human;improved;Individual;Injury;innovation;insight;Institution;Intervention;Kidney;Kidney Diseases;Knowledge;Knowledge Extraction;Laboratories;large scale data;Link;machine translation;Maps;metabolomics;Michigan;Molecular;molecular marker;molecular scale;Multiomic Data;National Institute of Diabetes and Digestive and Kidney Diseases;nephrogenesis;new therapeutic target;novel;outreach;Participant;Pathway interactions;patient population;Patients;Performance;Persons;Phenotype;Process;programs;Protocols documentation;Research;Research Personnel;research study;Research Training;Resource Development;Resources;Scientist;Services;skills;Social Network;Standardization;Structure;System;Systems Biology;Target Populations;Therapeutic;therapeutic target;tool;Training;Training Programs;Transcript;Translational Research;Translations;treatment response;treatment strategy;United States National Institutes of Health;Universities;Urology;Validation;Vision;Visualization software;Work

PROJECT_TITLE: Applied Systems Biology Core


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Behavioral and Social Science;Biodefense and Related Countermeasures;Brain Disorders;Epilepsy;Neurodegenerative;Neurosciences

ORG_CITY: RICHMOND

ORG_DEPT: NEUROLOGY

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

PHR: PROJECT NARRATIVE Lethal exposure to organophosphate (OP) compounds, including household pesticides and chemical warfare nerve agents (CWNA), produces status epilepticus (SE) and leads to the development of chronic neurological morbidities. This project will conduct safety and pharmacokinetic studies of intramuscular verapamil and study its neuroprotective and anti-inflammatory actions in a rat model of DFP-SE. In addition, we will optimize VPM therapy and study its effect in improving long-term cognitive impairment and seizure outcomes.

PI_NAMEs: DESHPANDE, LAXMIKANT S (contact)

PROGRAM_OFFICER_NAME: SPRIGGS, SHARDELL M

PROJECT_TERMS: Acetylcholinesterase Inhibitors;Acute;Alzheimer's disease model;Anti-Inflammatory Agents;Antiinflammatory Effect;Anxiety;Atropine;Attenuated;Behavioral;Behavioral Assay;Brain;Brain Injuries;Brain region;Calcium Binding;Calcium Channel Blockers;Caring;Cell model;central nervous system injury;Cessation of life;chemical threat;Chemical Warfare;cholinergic;Chronic;cognitive performance;cytokine;Development;Dose;Drug Kinetics;Early Intervention;effective therapy;Electroencephalography;Emergency Care;Enzyme Inhibitor Drugs;Exhibits;Exposure to;field study;fluoro jade;fluorophosphate;Formulation;functional outcomes;Glial Fibrillary Acidic Protein;Goals;Hour;Household;Hypertension;Immunohistochemistry;Impaired cognition;improved;in vivo;Industrialization;Inflammatory;insight;Intoxication;Intramuscular;Intramuscular Injections;ionization;Ischemia;Mediating;Midazolam;Modeling;Morbidity - disease rate;mortality;mossy fiber;nerve agent;Nerve Degeneration;neuroinflammation;Neurologic;Neurological outcome;neuron loss;Neuronal Injury;Neurons;neuroprotection;novel;novel therapeutics;object recognition;Organophosphates;Outcome;Parkinson Disease;Pesticides;Pharmaceutical Preparations;pharmacologic;Phase;programs;Property;Rattus;Recurrence;Reducing Agents;Reporting;Research Support;Rodent;Role;Safety;Seizures;Solvents;Stains;standard of care;Status Epilepticus;Stroke;Survivors;Techniques;Testing;Therapeutic;Toxic effect;toxic organophosphate insecticide exposure;treatment duration;United States National Institutes of Health;Up-Regulation;Verapamil;Water

PROJECT_TITLE: Identification and optimization of verapamil as a novel neuroprotective and anti-inflammatory agent for reducing long-term neurological morbidities following organophosphate-induced status epilepticus

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-KUDS-F(50)]


NIH_SPENDING_CATS: Clinical Research;Data Science;Kidney Disease;Networking and Information Technology R&D (NITRD)

PI_NAMEs: ATHEY, BRIAN DAVID (contact)

PROJECT_TERMS: Address;Advocate;analytical tool;Area;Back;base;bench to bedside;Biological Models;catalyst;Categories;Cells;Clinical;Clinical Markers;Clinical Trials;cohort;Cohort Studies;Collaborations;Communities;Community Outreach;Core Facility;Critical Pathways;Custom;Data;Data Analyses;Data Analytics;data exploration;data integration;data management;data mining;data resource;Data Set;data sharing;Databases;design;Development;Diagnosis;disadvantaged student;Disease Progression;disorder risk;Education;Effectiveness;empowerment;Ensure;Epidemiology;equity, diversity, and inclusion;Evaluation of Risk Factors;Feedback;Gene Expression;Genetic;Genotype;Goals;Health system;Hematology;Histologic;Human;human disease;human model;improved;Individual;Injury;Injury to Kidney;innovation;Institution;interest;Intervention;Kidney;Kidney Diseases;Knowledge;Knowledge Extraction;knowledgebase;large scale data;large-scale database;Link;longitudinal analysis;Maps;Michigan;Molecular;molecular marker;mouse model;Multiomic Data;multiscale data;Mus;National Institute of Diabetes and Digestive and Kidney Diseases;nephrogenesis;novel;Online Systems;Outcome;outreach;Participant;Pathway interactions;patient population;Patients;Performance;Persons;Phenotype;phenotypic data;pre-clinical;predictive modeling;Process;programs;Protocols documentation;Research;Research Personnel;Research Training;Resource Development;Resources;Sampling;search engine;Services;sharing platform;Social Network;Structure;System;Systems Biology;Target Populations;Therapeutic;tool;Training Programs;Translational Research;Translations;treatment response;treatment strategy;Universities;Update;Urology;user-friendly;Validation;Vision;web portal;Work

PROJECT_TITLE: Data Analytic Services Core


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Immunotherapy;Prostate Cancer;Urologic Diseases

ORG_DEPT: PATHOLOGY

PHR: Project Narrative: Advanced metastatic prostate and breast cancers account for the majority of cancer-related deaths. This project will delineate molecular mechanisms of therapy-resistance and metastasis in hormone-receptor driven malignancies and will employ an integrative computational and experimental approach to identify and validate new molecular targets that specify cellular identity in cancer. These findings will enable the development of novel innovative therapies to improve patient survival.

PI_NAMEs: PAROLIA, ABHIJIT  (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: Academia;Address;Affinity;androgen independent prostate cancer;Androgen Receptor;Androgens;Architecture;Automobile Driving;beta catenin;Binding;Bioinformatics;Biological Assay;C-terminal;cancer cell;Cancer Patient;cancer type;Castration;Cessation of life;ChIP-seq;Chromatin;Classification;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;cofactor;cohort;cytotoxic CD8 T cells;derepression;Development;Disease;Disease remission;Disseminated Malignant Neoplasm;DNA;DNA Binding Domain;Doctor of Philosophy;Engineering;Environment;Epigenetic Process;epigenomics;Essential Genes;experimental study;Foundations;Frameshift Mutation;Future;gain of function;Genetic;Genetic Enhancer Element;Genetic Transcription;genomic data;Genomics;Heterozygote;Hormone Receptor;Hormones;improved;Incidence;innovation;Innovative Therapy;insertion/deletion mutation;insight;Knowledge;Malignant Breast Neoplasm;Malignant neoplasm of prostate;Malignant Neoplasms;malignant phenotype;Mentors;Metastatic Prostate Cancer;Molecular;Molecular Target;multidisciplinary;mutant;Mutation;Neoplasm Metastasis;Normal Cell;novel;novel therapeutic intervention;Nuclear;Oncogenes;Oncogenic;overexpression;Pathogenicity;Pathway interactions;Patients;Peer Review;Phase;Phenotype;Positioning Attribute;post-doctoral training;Postdoctoral Fellow;programs;Proliferating;Prostate;prostate cancer cell;Proteomics;Publications;Receptor Signaling;recruit;Recurrence;Reporter;Research;Research Personnel;Resistance;Role;Sampling;skills;Specific qualifier value;Structure;symposium;targeted treatment;Therapeutic;therapeutic target;Time;Tissues;Training;transcription factor;transcriptome sequencing;tumor;Tumor Antigens;tumor progression;tumorigenesis;Variant;Wing;WNT Signaling Pathway;Work

PROJECT_TITLE: SWI/SNF chromatin remodelers in tumor-associated antigen-specific CD8+ cytotoxic T cells


ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Project Narrative (Center Overview)  The Indiana O’Brien Center will (1) provide unique imaging services to the renal research community, including intravital microscopy and tissue molecular imaging, (2) training in advanced imaging technologies and (3) develop new technologies for large-scale, quantitative microscopy of the kidney. The Center will thus help renal investigators realize the potential of quantitative microscopy as a tool in renal research.

PI_NAMEs: DAGHER, PIERRE C (contact)

PROJECT_TERMS: 3-Dimensional;Applications Grants;Biological;biomedical resource;career;Collaborations;Communities;Cytometry;Data;design;Development;Diabetes Mellitus;digital imaging;Educational workshop;Environment;Equipment;experience;Functional disorder;Funding;Generations;Goals;Hematology;Human BioMolecular Atlas Program;Image;Image Analysis;Imaging technology;Indiana;Individual;Infrastructure;innovative technologies;Institution;intravital microscopy;Kidney;Left;Light;Methods;microscopic imaging;Microscopy;Mission;Molecular;molecular imaging;multi-photon;Mus;National Institute of Diabetes and Digestive and Kidney Diseases;Nebraska;Nephrology;new technology;novel;outreach;Physiology;precision medicine;programs;Publications;Quantitative Microscopy;Rattus;Renal Tissue;Reporter;Research;Research Personnel;Resolution;Resource Development;Resources;Services;synergism;Techniques;Technology;Tissues;tool;Training;transcriptomics;United States National Institutes of Health;Universities;Washington;Work

PROJECT_TITLE: Indiana Center for Advanced Renal Microscopy and Molecular Imaging


NIH_SPENDING_CATS: Biomedical Imaging;Kidney Disease

PROJECT_TERMS: Biological Markers;biomedical resource;Collaborations;Communication;Communities;Disease Progression;Education;Ensure;Future;Goals;Guidelines;imaging science;Indiana;intravital microscopy;Kidney;Kidney Diseases;Lead;microscopic imaging;molecular imaging;Monitor;outreach;Pathway interactions;preclinical study;programs;Research;Research Personnel;Resource Development;Resource Sharing;Resources;Services;targeted treatment;Testing;Therapeutic Intervention


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;HIV/AIDS;Heart Disease;Heart Disease - Coronary Heart Disease;Infectious Diseases

ORG_NAME: HENNEPIN HEALTHCARE RESEARCH INSTITUTE

PHR: Research and Health Implications: This proposal targets heart failure with preserved ejection fraction (HFpEF) among persons living with HIV in South Africa. This study will generate important data on the prevalence of heart failure overall and HFpEF specifically, as well as the potential mechanisms and co-morbid disease factors involved. Findings will expand our understanding of HIV-CVD in a global region where the majority of the HIV epidemic resides.

PI_NAMEs: BAKER, JASON V (contact);NTSEKHE, MPIKO

PROGRAM_OFFICER_NAME: KETEMA, FASSIL

PROJECT_TERMS: adjudication;Africa South of the Sahara;Age;Aging;antiretroviral therapy;Biological;Biological Factors;Biological Response Modifiers;biomarker driven;burden of illness;Cardiac;cardiometabolism;Cardiovascular Diseases;cardiovascular disorder risk;CD4 Lymphocyte Count;Chronic;Clinical;Clinical Research;Clinical Trials;clinically significant;cohort;comorbidity;coronary fibrosis;Coronary heart disease;Country;COVID-19;Data;Developing Countries;Diffuse;Diffuse Pattern;Disease;Early identification;Echocardiography;EFRAC;Enrollment;Epidemic;Etiology;experience;Fibrosis;Frequencies;Functional disorder;Goals;Health;Heart;Heart failure;heart failure with reduced ejection fraction;heart imaging;HIV;Hypertension;Immune Targeting;Immunologic Factors;Income;Individual;Infection;Injury;Intervention;Ischemia;Magnetic Resonance;Maps;Methods;Morbidity - disease rate;mortality;multidisciplinary;Mycobacterium tuberculosis;Myocardial;myocardial injury;Myocardial Ischemia;Obesity;Organ;Pathogenesis;Pathology;Pathway interactions;Patients;Pattern;Pericardial body location;Persons;Phenotype;point of care;preservation;Prevalence;Proteomics;Research;Risk;Risk Factors;Sex Differences;South Africa;Standardization;structural heart disease;Structure;Subgroup;substance use;systemic inflammatory response;Target Populations;Ventricular Dysfunction;Viral;Woman

PROJECT_TITLE: Clinical and immunologic factors underlying heart failure with preserved ejection fraction among persons with HIV in South Africa

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Data Science;Kidney Disease;Networking and Information Technology R&D (NITRD);Precision Medicine;Social Determinants of Health

PI_NAMEs: HAYEK, SALIM  (contact)

PROJECT_TERMS: Academy;accurate diagnosis;Acute Renal Failure with Renal Papillary Necrosis;Address;adjudication;Algorithms;annotation  system;base;Biological;Biological Assay;Biological Markers;biomarker discovery;candidate marker;candidate selection;Cells;Cessation of life;Characteristics;Chronic Kidney Failure;Clinical;Clinical Trials;Clinical Trials Design;clinically relevant;Code;cohort;Communities;Core Assembly;cost;cost effectiveness;Data;Data Analyses;Data Analytics;data integration;Data Set;Databases;design;Development;Diagnosis;Diagnostic;Disease;disease phenotype;Education;Educational workshop;epigenomics;Etiology;Feedback;follow-up;Goals;graphical user interface;Health;health data;Healthcare;improved;Incubators;indexing;Information Systems;Information Technology;Infrastructure;innovation;interest;Kidney;Kidney Diseases;Laboratories;Link;Measures;Medicine;metabolomics;Methods;Michigan;multidimensional data;multidisciplinary;Multiomic Data;multiple data sources;multiple omics;National Institute of Diabetes and Digestive and Kidney Diseases;Natural Language Processing;new technology;novel;novel strategies;Observational Study;Outcome;Pathway interactions;Patients;Phenotype;pragmatic implementation;pragmatic trial;Precision Health;Process;prognostic;Proteomics;Quality Control;Renal function;Research;Research Design;Research Personnel;Resolution;Resource Development;Resources;Sampling;Services;social health determinants;sociodemographics;specific biomarkers;Specificity;Structure;success;Systems Biology;Technology;technology platform;Testing;Text;Therapeutic;tool;Training and Education;Training Programs;transcriptomics;Translational Research;trend;United States;Universities;Validation;Work

PROJECT_TITLE: Resource Development Core


PI_NAMEs: DUNN, KENNETH W (contact)

PROJECT_TERMS: biomedical resource;Cellular biology;Communities;Development;Functional disorder;Funding;Guidelines;Home;Image Analysis;Indiana;Institution;intravital imaging;intravital microscopy;Kidney;Methods;microscopic imaging;Microscopy;Mission;molecular imaging;multi-photon;Mus;National Institute of Diabetes and Digestive and Kidney Diseases;novel;Physiology;Rattus;Research;Research Personnel;Resources;Services;Training

PROJECT_TITLE: Intravital Microscopy Biomedical Resource Core


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Clinical Research;Dental, Oral, and Craniofacial Disease;Genetics;Human Genome;Infectious Diseases;Microbiome

ORG_CITY: CAMBRIDGE

ORG_NAME: ADA FORSYTH INSTITUTE, INC.

ORG_STATE: MA

PHR: TITLE: Spatial Organization of the Oral Microbiome Project Narrative:  Bacteria colonizing the human mouth play important roles not only in oral health, but in systemic health and disease. This project addresses the key unsolved question of how micrometer-scale spatial organization of the oral microbiota is connected to its function. We will investigate how the spatial structure of bacterial communities affects their response to dietary nitrate, will determine whether bacteria function as clones or as complex mixtures of strains at micrometer scales, and will develop a new method for micrometer-scale imaging of the dynamics of multitaxon bacterial communities.

PI_NAMEs: MARK WELCH, JESSICA LEIGH (contact)

PROGRAM_OFFICER_NAME: MCNEALY, TAMARA L

PROJECT_TERMS: Actinomyces;Address;Affect;Animals;Architecture;Bacteria;bacterial community;Biological Models;Biology;blood pressure control;cardiometabolism;Cells;Characteristics;combinatorial;Communities;community organizations;Complex;Complex Mixtures;Corynebacterium;Data;Dental Plaque;Development;Diameter;dietary nitrate;Disease;DNA Sequence Analysis;Dyes;Ecology;Environment;Fluorescent in Situ Hybridization;Foundations;Fusobacterium;Generations;Goals;Grant;Growth;Health;host microbiome;Human;Image;imaging system;improved;In Vitro;in vitro Model;in vivo;Individual;Industrialization;Label;Learning;live cell imaging;Measures;member;Metabolism;Metagenomics;meter;Methods;microbial;Microbial Biofilms;microbial community;microbiome;microbiome composition;microbiota;microbiota transplantation;Microdissection;millimeter;Modeling;Neighborhoods;Neisseria;Nitrates;Nitric Oxide;novel therapeutics;Oral;oral biofilm;Oral cavity;Oral health;oral microbial community;oral microbiome;Persons;Physiology;Play;Population;Positioning Attribute;Prevotella;probiotic therapy;Research;Resolution;response;Role;Saliva;Salivary;Salivary Glands;Shotguns;Site;spatial relationship;spectrograph;Stains;Streptococcus;Structure;Structure-Activity Relationship;Supplementation;Surface;System;Taxon;Tissues;Tongue;tongue dorsum;Vasodilation;Veillonella;volunteer;whole genome;Whole-Genome Shotgun Sequencing;Work

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]


PI_NAMEs: ASHKAR, TAREK MAURICE (contact)

PROJECT_TERMS: 3-Dimensional;Animal Experiments;Biological Markers;biomedical resource;Cell Communication;cell type;Cells;Chromosome Mapping;Communities;Cytometry;Data;Detection;Disease Progression;Ensure;experimental analysis;Goals;Guidelines;Histopathology;Human;Immune;indexing;Indiana;Individual;Injury;Kidney;Kidney Diseases;microscopic imaging;molecular imaging;Morphology;National Institute of Diabetes and Digestive and Kidney Diseases;Neighborhoods;Output;Phenotype;Population;preclinical study;Proteomics;Research;Research Personnel;Services;Signal Transduction;Specimen;targeted treatment;Technology;Testing;Therapeutic Intervention;Three-Dimensional Imaging;Tissues;transcriptomics

PROJECT_TITLE: Molecular Imaging Biomedical Resource Core


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Kidney Disease;Networking and Information Technology R&D (NITRD)

PROJECT_TERMS: 3-Dimensional;automated image analysis;Cells;Data;Development;Educational workshop;Guidelines;Human;Hybrids;Image;Indiana;Kidney;Kidney Diseases;Light;method development;Methods;Microscope;microscopic imaging;Microscopy;molecular imaging;Mus;novel;online repository;Population;Publications;Renal function;Research;Research Personnel;Resolution;Resource Development;Rodent;Services;System;Technology;Tissues;tool;transcriptomics


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cardiovascular;Cerebrovascular;Dementia;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hypertension;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Sleep Research;Social Determinants of Health;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: BOSTON

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: PROJECT NARRATIVE We will use a comprehensive dataset of diverse Latinos from the Hispanic Community Health Study/Study of Latinos to characterize biological mechanism underlying the relationship between sleep and incident cardiometabolic and neurocognitive outcomes. We will identify and construct metabolomics and methylation biomarkers of sleep phenotypes and study how these biomarkers associate with health and disease outcomes. We will study how sleep modifies effects of polygenic risk scores on outcomes and quantify the potential reduction in risk due to intervention on sleep and the resulting modification of omics pathways.

PI_NAMEs: SOFER, TAMAR  (contact)

PROGRAM_OFFICER_NAME: YE, JANE

PROJECT_TERMS: Address;Affect;Alzheimer's Disease;Atherosclerosis Risk in Communities;Automobile Driving;Behavioral;Biological;Biological Markers;cardiometabolism;cardiovascular risk factor;Central American;Clinical;Cognitive;cognitive function;cohort;Collection;Communities;Cuban;Data;data integration;Data Set;Development;Diabetes Mellitus;diabetes risk;Disease;Disease Outcome;disorder risk;Dominican;Educational workshop;Environment;Epigenetic Process;experience;Frequencies;Genes;Genetic;Genetic Determinism;Genetic Risk;Geographic Locations;Goals;Health;health determinants;health disparity;High Prevalence;Hispanic Community Health Study/Study of Latinos;Hispanic Populations;Hypertension;Impaired cognition;improved;improvement on sleep;Individual;innovation;Interdisciplinary Study;Intervention;Latino;Latino Population;Life Style;lifestyle factors;Link;Longitudinal cohort study;Measures;Mediation;metabolomics;Methylation;methylation biomarker;Mexican;modifiable risk;Modification;Morbidity - disease rate;multidimensional data;multiple omics;National Heart, Lung, and Blood Institute;Neurocognitive;Obesity;Outcome;Pathway interactions;Phenotype;polygenic risk score;Population;Predisposition;Primary Prevention;public health intervention;Puerto Rican;Research;resilience factor;Risk;Risk Factors;secondary analysis;sex;Site;Sleep;Sleep Disorders;sleep health;social;social culture;sociocultural determinant;South American;Study of Latinos;Testing;Vascular Dementia;Work

PROJECT_TITLE: Leveraging omics data to understand sleep health and its consequences among diverse Hispanics/Latinos

STUDY_SECTION: CHSA

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology A Study Section[CHSA]


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Drug Abuse (NIDA only);Neurosciences;Opioid Misuse and Addiction;Opioids;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Substance Misuse

ORG_CITY: SEATTLE

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative Fetal brain-derived signals in the blood of pregnant women represent a way to get a snapshot of fetal brain health during development, but analyzing these signals requires highly sensitive technology. Our proposed studies will use our newly developed highly sensitive flow technologies to analyze these particles in women with healthy pregnancies and in women using opioid drugs. This will allow us to develop biomarkers to determine if newborns exposed to opioid drugs in utero will need treatment for neonatal abstinence syndrome.

PI_NAMEs: CHIU, DANIEL T (contact);VOJTECH, LUCIA N

PROGRAM_OFFICER_NAME: WU, DA-YU

PROJECT_TERMS: Address;Affinity;Biological;Biological Assay;Biological Markers;Birth;Blood;Brain;Brain Diseases;brain health;candidate identification;Cells;Central Nervous System;Centrifugation;cognitive function;Complex;contactin;Detection;Development;Dose;Dyes;Enzyme-Linked Immunosorbent Assay;Exclusion;experience;Exposure to;extracellular;extracellular vesicles;fetal;fetal brain injury;Flow Cytometry;Fluorescence;Fluorescence-Activated Cell Sorting;fluorophore;Genetic;Glycoproteins;Growth;Health;healthy pregnancy;Heterogeneity;HIV Infections;In Situ;in utero;Individual;Infant;insight;maternal opioid use;Membrane Proteins;Methodology;Methods;Molecular;Mothers;Neonatal Abstinence Syndrome;neonate;neurodevelopment;new technology;Newborn Infant;non-drug;Nucleic Acids;Opioid;opioid epidemic;opioid exposure;opioid therapy;opioid use;opioid use disorder;Outcome;particle;Pathologic;Pathway interactions;Penetration;Peptides;Pharmaceutical Preparations;Pharmacotherapy;Phenotype;Physiological;Placenta;Plasma;Polymers;Population;Precipitation;Predisposition;Pregnancy;Pregnancy Complications;Pregnant Women;Process;Proteins;Public Health;Reporting;response;Reverse Transcriptase Polymerase Chain Reaction;Risk;Risk Assessment;RNA;Sampling;Second Pregnancy Trimester;Seizures;Severities;Signal Transduction;Sorting;Stains;Substance Use Disorder;Surface;Surveys;Synaptophysin;Systems Analysis;Techniques;Technology;Third Pregnancy Trimester;tool;Treatment Cost;United States;Western Blotting;Woman;Work

PROJECT_TITLE: Assessment of fetal brain health via circulating exRNA carriers for opioid use disorder in pregnancy

STUDY_SECTION: CMT

STUDY_SECTION_NAME: Cellular and Molecular Technologies Study Section[CMT]