NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Biotechnology;Cancer;Cancer Genomics;Clinical Research;Dissemination and Implementation Research;Genetics;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Human Genome;Prevention;Racial and Ethnic Minority Health Research;Rural Health

PI_NAMEs: SUSSMAN, ANDREW LOUIS (contact)

PROJECT_TERMS: Address;Affect;Agreement;American Indian community;American Indians;anti-cancer research;Apache Tribe;barrier to care;Behavioral;Benchmarking;Black race;cancer genome;cancer genomics;Cancer Patient;Cancer Survivor;Clinical;clinical care;Collaborations;Collection;Communication;Communities;community engagement;Comprehensive Cancer Center;Consent;Counseling;Data Analyses;Data Collection;data tools;deprivation;design;Disparity;Eligibility Determination;eligible participant;Ensure;Epidemiology;Evaluation;experience;Frequencies;Future;Genetic Counseling;genetic information;genome sequencing;genomic data;Genomics;Geography;Goals;Health;Health Policy;Heterogeneity;implementation strategy;Incidence;Indigenous;Informed Consent;innovation;Knowledge;Language;Letters;Linguistics;Malignant Neoplasms;Measures;Methods;Molecular;Monitor;multimodality;Navajo;New Mexico;Outcome;Participant;Pathology;patient engagement;patient oriented;Patients;Performance;Persons;Phase;Population;precision medicine;Procedures;Process;Protocols documentation;Pueblo Race;Reach, Effectiveness, Adoption, Implementation, and Maintenance;recruit;Research;Resolution;Resources;Sampling;scientific literacy;Screening for cancer;Service delivery model;Structure;Surveys;Survivors;telegenetics;Tissues;Translating;tribal community;Tribal Council;tribal Nation;Tribes;tumor;Visual;web portal

PROJECT_TITLE: Participant Engagement Unit


ADMINISTERING_IC: EY

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL EYE INSTITUTE

ORG_CITY: Los Angeles

ORG_COUNTRY: UNITED STATES

ORG_DEPT: OPHTHALMOLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

ORG_STATE: CA

PHR: PROJECT NARRATIVE: OVERALL CENTER CORE The Center Core Grant for Vision Research will provide shared resources accessible to a group of independently-funded investigators to enhance their research capabilities and productivity. It will also create an environment conducive to collaborative scientific interactions and inter-disciplinary vision science research focused on advancing knowledge of the visual system and treatments for vision impairment.

PI_NAMEs: SHAHIDI, MAHNAZ  (contact)

PROGRAM_OFFICER_NAME: GOVER, TONY DOUGLAS

PROJECT_TERMS: Animal Model;Biology;California;cellular imaging;Center Core Grants;collaborative environment;Data Science Core;Dedications;Diagnosis;Emerging Technologies;Engineering;Ensure;Environment;experience;Eye diseases;Fostering;Functional disorder;Funding;Goals;Grant;imaging science;in vivo imaging;innovation;innovative technologies;instrumentation;Interdisciplinary Study;K-Series Research Career Programs;Knowledge;Mentors;novel diagnostics;novel therapeutic intervention;Productivity;programs;Research;Research Personnel;Research Project Grants;Resource Sharing;Resources;success;Technical Expertise;Therapeutic;Tissue imaging;United States National Institutes of Health;Universities;vision development;Vision research;vision science;Visual impairment;Visual System

PROJECT_TITLE: Center Core Grant for Vision Research


ADMINISTERING_IC: NS

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Biotechnology;Chronic Pain;Clinical Research;Genetics;Human Genome;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PI_NAMEs: CAVALLI, VALERIA  (contact)

PROJECT_TERMS: Acceleration;Acute Pain;Adult;Affect;Afferent Neurons;American;Antibodies;Architecture;ATAC-seq;Atlases;Bioinformatics;Biological Markers;Biological Models;Blood Vessels;cancer therapy;Cell Communication;Cell Nucleus;Cell Physiology;cell type;Cells;Chromatin;chronic pain;chronic painful condition;Classification;Communicable Diseases;computational pipelines;Consent;Cytometry;Data;Data Analyses;Data Set;design;Detection;Development;Diabetes Mellitus;Diabetic Neuropathies;disease prognosis;Disease Progression;Environment;Future;ganglion cell;Gene Expression;Gene Expression Profile;Gene Expression Profiling;Genes;Genetic Markers;Genetic Transcription;Genomics;Goals;Human;human tissue;Image;Immune;Immunology;improved;Infectious Diseases Research;insight;inter-individual variation;knowledge translation;Malignant Neoplasms;Maps;Measurement;Measures;Messenger RNA;Methods;Molecular;Molecular Profiling;Natural regeneration;nerve injury;Neuroglia;neuronal cell body;Neurons;Nociceptors;novel therapeutics;Operative Surgical Procedures;opioid overuse;Organ;Organ Donor;Pain;pain perception;Pain Research;Pathologic;Pathway Analysis;Pathway interactions;Peripheral;Peripheral Nervous System Diseases;peripheral pain;Population;Positioning Attribute;pre-clinical;Preparation;Process;protein biomarkers;protein expression;Proteins;Proteomics;Quality Control;Recording of previous events;Research;Resolution;response;Rodent;Rodent Model;Role;Sampling;Sensory;Shapes;Signal Transduction;single cell sequencing;single nucleus RNA-sequencing;spatial relationship;Spinal Ganglia;Taxonomy;Technology;Testing;Tissue Donations;Tissue-Specific Gene Expression;Tissues;tool;transcriptome;transcriptome sequencing;transcriptomics;Translational Research;Translations;transmission process;Treatment outcome;Validation;Visualization

PROJECT_TITLE: Characterization of human DRG at the single cell level via integrated transcriptomics and spatial proteomics


ADMINISTERING_IC: GM

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: SPOKANE VALLEY

ORG_NAME: HEALING LODGE OF THE SEVEN NATIONS

ORG_STATE: WA

PHR: PROJECT NARRATIVE: OVERALL With proper training, people can stabilize mental health crisis situations, such as youth in recovery risking relapse, until professional help is available. However, tribal communities might require culturally-appropriate approaches to be most successful, which led to the development of a new mental health support training system for tribal communities, xaʔtus for Mental Health. To ensure that xaʔtus for Mental Health is an effective evidence- based public health intervention system, the proposed set of studies and capacity building activities will rigorously evaluate the program, further advance its development, and ensure its widespread use among tribal communities.

PI_NAMEs: LAPLANTE, DEBI A;WHELSHULA, MARTINA  (contact)

PROGRAM_OFFICER_NAME: RICHARDS, CRYSTAL LYNETTE

PROJECT_TERMS: addiction;Adolescent;Adolescent Behavior;adolescent mental health;adolescent substance use;Adult;Advanced Development;Aftercare;Anxiety;Award;Awareness;Back;Behavior;Belief;care providers;Coeur D'Alene;Collaborations;Communities;Community Surveys;Competence;Development;Education;Ensure;Evaluation;evidence base;experience;Face;Funding;Goals;healing;Health;Health Alliance;health knowledge;health training;Healthcare;Indigenous;insight;intergenerational;Intervention;Kalispel;Knowledge;Kootenai;Learning;learning outcome;long term recovery;Manuals;medical schools;member;Mental Depression;Mental Health;Names;Native American Research Center for Health;Native Americans;Nature;Needs Assessment;Persons;Pilot Projects;Productivity;Program Development;Program Effectiveness;programs;project-based learning;Public Health;public health intervention;Randomized;Recording of previous events;Recovery;Recovery Support;Relapse;Research;research and development;Research Methodology;Research Project Grants;research study;Reservations;Resources;response;Safety;Science;Self Care;Self-Injurious Behavior;skills;social stigma;social structure;Students;Substance Use Disorder;Support System;Surveys;System;Teaching Hospitals;Testing;Trainers Training;Training;training opportunity;Training Support;Trauma;treatment center;tribal community;tribal Nation;Tribally Based Participatory Research;Tribes;Umatilla;uptake;Violence;Waiting Lists;Work;Youth

PROJECT_TITLE: Assessing Cultures of Recovery in Tribal Communities


NIH_SPENDING_CATS: Brain Disorders;Chronic Pain;Clinical Research;Genetics;Neurosciences;Opioid Misuse and Addiction;Opioids;Pain Research;Substance Misuse

PI_NAMEs: GEREAU, ROBERT W (contact)

PROJECT_TERMS: addiction;Address;American;Analgesics;Anatomy;aspirate;Axon;Biological Assay;Catalogs;cell type;Cells;Central Nervous System;chronic pain;chronic pain patient;chronic painful condition;Data;Data Set;Development;Diagnosis;Electrophysiology (science);evidence base;Gene Expression Profile;Genetic;Genetic study;Genetic Transcription;Goals;Helping to End Addiction Long-term;Human;Knowledge;Location;Maintenance;Maps;Membrane;Molecular;Morphology;Nervous System;Neurons;novel;Opioid;opioid epidemic;opioid misuse;opioid mortality;opioid use;opioid use disorder;Pain;Pain management;patch clamp;patch sequencing;Patients;Pharmaceutical Preparations;Phenotype;Physiological;Physiology;Population;Positioning Attribute;Posterior Horn Cells;Preparation;Property;Protocols documentation;reconstruction;Recording of previous events;Research;Resolution;Resources;Risk;single-cell RNA sequencing;Slice;Spinal;Spinal Cord;Spinal Ganglia;Structure;substance misuse;substance use;Synapses;Tissues;tool;transcriptome sequencing;transcriptomics;transmission process;United States National Institutes of Health;Work

PROJECT_TITLE: Functional and genetic characterization of human DRG and spinal cord at single cell resolution


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Brain Disorders;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: WINSTON-SALEM

ORG_DEPT: NEUROSCIENCES

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

ORG_STATE: NC

PHR: PROJECT NARRATIVE The proposed experiments will reveal how prefrontal cortex activity may be responsible for performance of visual, short-term memory tasks. Training in such tasks has shown great promise in alleviating deficits from traumatic brain injury, stroke, neurological disorders, and mental illnesses. Our results will thus reveal how interventions can be optimized to enhance memory.

PI_NAMEs: JAFFE, RYE  (contact)

PROGRAM_OFFICER_NAME: CLAYTON, EDWIN C

PROJECT_TERMS: Affect;Alzheimer's Disease;Animals;Area;Behavioral;Brain;Cells;Chronic;Conscious;cost;Cues;Development;Disease;Electric Stimulation;Electrodes;Etiology;experimental study;Functional Magnetic Resonance Imaging;Human;Implanted Electrodes;insight;Intervention;Judgment;Lateral;Location;Macaca;Macaca mulatta;Maintenance;Manuals;Measures;Mediating;Mediation;member;Memory;Mental disorders;Metabolic;Microelectrodes;Mind;Modeling;Monkeys;Nervous System Disorder;neural;neural correlate;Neurons;neurophysiology;nonhuman primate;novel;novel therapeutics;Play;Population;Prefrontal Cortex;Reporting;Research;Research Personnel;response;Role;sensory cortex;Short-Term Memory;simulation;Site;Stimulus;Stroke;Surface;Synapses;Testing;Time;Training;Traumatic Brain Injury;Visual;visual performance;visual stimulus

PROJECT_TITLE: The Role of Persistent Activity in Visual Working Memory


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biomedical Imaging;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: LOS ANGELES

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE Isocitrate dehydrogenase (IDH)-mutant gliomas have distinct metabolic characteristics and therapeutic vulnerabilities. However, advanced imaging biomarkers of IDH-mutant glioma remain limited for malignant transformation and new IDH inhibition therapy. Our proposed studies will utilize molecular MR-PET imaging to identify imaging biomarkers that could improve the clinical management of IDH-mutant gliomas.

PI_NAMEs: CHO, NICHOLAS S. (contact)

PROGRAM_OFFICER_NAME: PURI, ANU

PROJECT_TERMS: Accounting;Acidity;Address;Affect;anatomic imaging;Anatomy;angiogenesis;Area;Biological;Biological Markers;Biopsy;Blood - brain barrier anatomy;Blood Vessels;Blood Volume;Cell Density;Cell Proliferation;Cellularity;cerebral blood volume;Characteristics;Classification;Clinical;Clinical Management;Codon Nucleotides;contrast enhanced;density;Diffusion;Diffusion Magnetic Resonance Imaging;Disease;Early identification;Enzymes;Event;Extravasation;fluorodeoxyglucose;follow-up;Functional Imaging;gain of function;Glioma;Glycolysis;Goals;Histologic;Histology;Human;Hypoxia;Hypoxia Inducible Factor;Image;image guided;imaging biomarker;improved;Indolent;inhibitor;inhibitor therapy;insight;Intervention;Isocitrate Dehydrogenase;lactate dehydrogenase A;longitudinal analysis;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Malignant - descriptor;Malignant Glioma;malignant phenotype;Measurable;Measurement;Metabolic;metabolic imaging;Microvascular Proliferation;Modality;Molecular;mutant;Mutation;mutational status;Nature;neoplastic cell;new therapeutic target;non-invasive imaging;Operative Surgical Procedures;patient population;Patients;PECAM1 gene;Perfusion;Physiological;Positron-Emission Tomography;Process;Prognosis;Recurrence;response;S-Phase Fraction;serial imaging;Signal Transduction;standard of care;targeted treatment;theories;Therapeutic;Therapeutic Intervention;Tissues;Treatment Failure;treatment response;tumor;tumor growth;tumor microenvironment;uptake;World Health Organization

PROJECT_TITLE: Molecular MR-PET to characterize malignant transformation and identify therapeutic vulnerabilities in human IDH-mutant gliomas


NIH_SPENDING_CATS: American Indian or Alaska Native;Biotechnology;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Genetic Testing;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research;Rural Health

ORG_CITY: ALBUQUERQUE

ORG_NAME: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR

ORG_STATE: NM

PI_NAMEs: TRENT, JEFFREY M. (contact)

PROJECT_TERMS: Address;Affect;Agreement;American Indian Population;American Indians;Aneuploidy;Architecture;Arizona;Atlases;bioinformatics pipeline;cancer care;Cancer Etiology;cancer genome;cancer health disparity;Cancer Patient;cancer predisposition;cancer survival;Cancer Survivor;cancer therapy;CLIA certified;Clinical;Clinical Data;Clinical Research;clinical sequencing;Clinical Trials;Communities;Community Clinical Oncology Program;Coupling;Data;Data Commons;Data Coordinating Center;data exchange;Data Reporting;Data Set;data sharing;Development;exome sequencing;Frequencies;Funding;Future;Gene Mutation;Genes;genetic counselor;genetic information;Genome;genome analysis;genome sequencing;genomic data;Genomic Data Commons;genomic profiling;Genomics;Geography;Germ Lines;Germ-Line Mutation;Hereditary Malignant Neoplasm;improved;Incidence;Individual;Information Systems;Informed Consent;Infrastructure;innovation;instrument;Laboratories;Location;Loss of Heterozygosity;Malignant Neoplasms;Maps;Measures;Medical;meetings;Minority;Molecular;mortality;multiple omics;Mutation;Mutation Spectra;New Mexico;novel;Output;Participant;Pathogenicity;Pathology Report;Patient Care;patient engagement;Patients;Performance;personalized intervention;Pharmaceutical Preparations;Physicians;Play;Population;preventive intervention;Process;programs;Publishing;Recording of previous events;Reference Standards;Reporting;Research;Role;Running;Sampling;screening;Screening for cancer;Secure;Security;Single Nucleotide Polymorphism;Somatic Mutation;Southwestern United States;Survival Rate;Susceptibility Gene;Testing;The Cancer Genome Atlas;Therapeutic Intervention;Time;Tissues;tool;transcriptome sequencing;Translating;tribal community;tribal leader;tribal Nation;Tribes;Trust;tumor;tumor exome;tumor registry;Tumor Subtype;United States National Institutes of Health;Variant;whole genome;Work

PROJECT_TITLE: Genome Characterization Unit


ADMINISTERING_IC: HL

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease;Regenerative Medicine

ORG_CITY: SAN DIEGO

ORG_NAME: VENTRIX, INC.

PHR: Project Narrative The development of therapies to treat myocardial infarction is a necessity because of the large patient population that declines into heart failure. This proposal seeks to perform final pre-clinical studies to translate a novel catheter deliverable biomaterial therapy for treating acute myocardial infarction.

PI_NAMEs: KINSEY, ADAM M (contact)

PROGRAM_OFFICER_NAME: LUNDBERG, MARTHA

PROJECT_TERMS: Acetylcholine;Acute myocardial infarction;American;Apoptosis;Area;Arrhythmia;Balloon Angioplasty;Biocompatible Materials;Biological Products;Businesses;Cardiac Myocytes;Catheters;Cause of Death;Cell Therapy;Cells;Clinic;Clinical;Clinical Research;Clinical Trials;commercialization;Contracts;Coronary Angiography;cost comparison;Development;Development Plans;Echocardiography;Eligibility Determination;Endothelium;Environment;Extracellular Matrix;Family suidae;Fibrosis;Geometry;Germ Cells;Good Manufacturing Process;Heart;Heart failure;heart function;Histology;Holter Electrocardiography;Hydrogels;Immunohistochemistry;improved;inflammatory milieu;Infusion procedures;Injectable;Injections;interest;Intervention;ischemic cardiomyopathy;Left Ventricular Remodeling;Magnetic Resonance Imaging;manufacture;Marketing;Meta-Analysis;Metabolism;minimally invasive;Modeling;Myocardial;Myocardial Infarction;Myocardium;neovascularization;novel;novel therapeutics;Pathway interactions;patient population;Patients;Phase;Phase I Clinical Trials;phase II trial;pre-clinical;Pre-Clinical Model;preclinical study;pressure;Procedures;Rattus;Recording of previous events;Recurrence;regenerative;Regenerative Medicine;repaired;research study;Risk;Safety;safety assessment;Small Business Innovation Research Grant;standard of care;statistics;Structure;success;therapy development;Therapy trial;Tissue Engineering;Tissues;Toxicology;Translating;Translations;United States National Institutes of Health;Work

PROJECT_TITLE: Pivotal Preclinical Studies of Novel Infusible ECM for Treating Acute MI


NIH_SPENDING_CATS: Chronic Pain;Clinical Research;Neurosciences;Pain Research;Transplantation

PI_NAMEs: COPITS, BRYAN  (contact)

PROJECT_TERMS: Bar Codes;biobank;Biological;Biological Factors;Biopsy;Body Fluids;Cancer Center;Catalogs;clinical diagnosis;Collaborations;Computer software;Core Facility;Data;Databases;Disease;experience;experimental study;Genetic;Human;human disease;human tissue;insight;Knowledge;Link;Medical;Medical History;Medical Records;medical schools;Nerve;Nervous System;neural;neurosurgery;Neurosurgical Procedures;opioid use disorder;Organ Procurements;Orthopedic Surgery;Orthopedics;Pain;Pain Clinics;Pain Research;Pathology;patient health information;Patients;Peripheral Nerves;Phenotype;pre-clinical;Procedures;Process;programs;Protocols documentation;Research;Research Personnel;Research Project Grants;Resources;Sampling;Secure;Services;Source;Spinal Cord;success;synergism;System;Tissue Preservation;tissue processing;Tissue Procurements;Tissue Sample;Tissues;Transplantation;Universities;Washington;Work

PROJECT_TITLE: Core B: Tissue Procurement and Processing


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Chronic Pain;Neurosciences;Pain Research;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: CAMBRIDGE

ORG_NAME: QUIVER BIOSCIENCE INC.

ORG_STATE: MA

PHR: Project Narrative There is a vital unmet medical need for new and effective therapeutics for neurological disorders, yet the drug development process remains a challenge due in large in part to a lack of translatable assays, models, and technologies to identify novel drug candidates. Q-State Biosciences has built an industry leading platform that combines cell-based disease models, engineered proteins, custom automated microscopes, and advanced analytics to allow visualization and characterization of electrical signaling in excitable, disease-relevant cell types such as neurons. Here, we propose to build an ultra-high throughput screening instrument that leverages our proprietary optogenetic tools for light-based stimulation and recording of electrophysiology and sensitive camera-based detection for robust measurements of cellular activity whereby successful execution of the proposal will enable a broad suite of novel assays on a wide range of excitable cell types for drug discovery in disorders of the nervous system, including areas of significant need such as chronic pain and severe epilepsy.

PI_NAMEs: DEMPSEY, GRAHAM THOMAS;LU, YANG  (contact)

PROGRAM_OFFICER_NAME: AUBRECHT, TARYN GRACE

PROJECT_TERMS: Accounting;Action Potentials;Address;advanced analytics;Area;Automation;Biological Assay;Biological Sciences;Calcium;Calibration;Cardiotoxicity;Cell Culture Techniques;cell type;Cells;Cellular Assay;Central Nervous System Diseases;channel blockers;Chemicals;chronic pain;commercial application;Commercial grade;commercialization;Complement;Custom;Data Compression;design;Detection;Developed Countries;Development;Disease;disease model;drug candidate;drug development;drug discovery;Drug Industry;Drug Screening;Drug Targeting;Electronics;Electrophysiology (science);Epilepsy;Evaluation;FDA approved;Fluorescence;high throughput screening;Human;human induced pluripotent stem cells;improved;induced pluripotent stem cell derived cardiomyocytes;Industry;Infrastructure;inhibitor;instrument;Laboratory culture;Lasers;Libraries;Life;Light;Lighting;Liquid substance;Measurement;Measures;Medical;Membrane;Membrane Potentials;Microscope;Modeling;multiplex assay;National Institute of Neurological Disorders and Stroke;Nervous System Disorder;neuronal excitability;Neurons;Neurosciences;Neurosciences Research;next generation;novel;novel therapeutics;Optics;optogenetics;Pain;Pain management;Performance;pharmacologic;Phase;presynaptic;Procedures;Process;Protein Engineering;Protocols documentation;Rattus;Reader;Resolution;response;Running;SCN1A protein;SCN2A protein;SCN8A gene;screening;Screening procedure;sensor;Signal Transduction;Small Business Innovation Research Grant;small molecule;small molecule inhibitor;small molecule libraries;Sodium Channel;Source;Stimulus;success;Techniques;Technology;Testing;Therapeutic;therapeutic candidate;therapeutically effective;Time;tool;United States;United States National Institutes of Health;Variant;Visualization;voltage;Work

PROJECT_TITLE: Ultra-High-Throughput Plate Reader for Drug Discovery Using All-Optical Electrophysiology


NIH_SPENDING_CATS: Chronic Pain;Clinical Research;Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Neurosciences;Pain Research

PI_NAMEs: JIN, SHENG CHIH  (contact)

PROJECT_TERMS: American;Anatomy;Bioinformatics;cell type;Cells;chronic pain;chronic pain patient;chronic painful condition;Collaborations;Communities;Community Developments;Complex;Complex Analysis;computerized data processing;Data;Data Analyses;data curation;data dissemination;data ecosystem;data integration;data management;Data Management Resources;data quality;Data Security;Data Set;data standards;Data Storage and Retrieval;data submission;Dedications;Deposition;design;Electrophysiology (science);Ensure;experience;Experimental Designs;Fostering;Genes;genome sequencing;Genomics;Goals;Human;Individual;innovation;Knowledge;Medical;member;Metadata;Methodology;Multiomic Data;multiple omics;Neuroglia;Neuroma;Neurons;new therapeutic target;novel therapeutics;Pain;Pain Clinics;Pain management;Pain Research;patch sequencing;Pathologic;Pathway interactions;Peripheral Nerves;Peripheral Nervous System;Peripheral Nervous System Diseases;Physiological;Property;Proteomics;Quality Control;Research;research and development;Research Personnel;Resources;Role;Secure;Services;single nucleus RNA-sequencing;Site;Spinal Ganglia;Statistical Data Interpretation;success;System;Therapeutic;therapeutic development;therapeutic target;Therapeutic Uses;Time;Tissues;transmission process;Validation;Vertebral column;whole genome

PROJECT_TITLE: Core C: Data


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Colorectal Cancer;Digestive Diseases;Radiation Oncology;Rare Diseases

ORG_CITY: NEW YORK

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PI_NAMEs: FORMENTI, SILVIA C. (contact)

PROJECT_TERMS: Achievement;Adjuvant Radiotherapy;Adverse event;Advocate;Age;Award;candidate identification;Charge;Clinical Trials;Collaborations;Colorectal;Communication;community building;Data;Data Analyses;Data Element;Data Scientist;data sharing;Descriptor;design;Discipline;Electronic Mail;Ensure;Equilibrium;Ethics;Europe;Evaluation;experience;Feedback;Funding;Future;Gender;Generations;Grant;Image;Immune;Immune response;Immune system;Immunity;Immunology;Immunooncology;Infrastructure;Institution;Intellectual Property;international center;Investigation;Legal;Link;Malignant Neoplasms;Medicine;meetings;member;microbiome;Modeling;Molecular;Monitor;Nature;Neoadjuvant Therapy;Newsletter;novel;organizational structure;Patients;Performance;Physicians;Pilot Projects;Process;programs;prospective;Radiation;radiation effect;Radiation Oncology;Radiation therapy;Radiobiology;Radiometry;radiomics;recruit;Rectal Cancer;Reporting;Research;Research Project Grants;Resource Sharing;Rest;Robin bird;Role;Running;Scientist;Secure;Self Assessment;Site;Specific qualifier value;Specimen;success;Tissues;tool;Training;Training Activity;tumor;Tumor stage

PROJECT_TITLE: Administrative Core


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Genetics;Infectious Diseases;Lung;Prevention

ORG_CITY: PITTSBURGH

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: SARS-CoV-2 is a novel ß-coronavirus that causes the disease called COVID-19, which is responsible for over 5 million deaths since late 2019. We propose using molecular virology assays and live-cell and super-resolution microscopy to visualize important processes that occur during SARS-CoV-2 replication after entry into human airway cells, including evaluation of variants of concern. Improved understanding of SARS-CoV-2 infection may lead to more effective COVID-19 therapies for infected individuals and could prepare us for preventing new coronaviruses that arise in the future.

PI_NAMEs: AMBROSE, ZANDREA  (contact)

PROGRAM_OFFICER_NAME: PLIMACK, MARY KATHERINE BRADFORD

PROJECT_TERMS: 2019-nCoV;Acute respiratory infection;airway epithelium;betacoronavirus;Biogenesis;Biological;Biological Assay;cell fixing;Cell Line;Cell membrane;Cells;Cellular biology;Cessation of life;Chiroptera;Complex;Confocal Microscopy;Coronavirus;COVID-19;COVID-19 mortality;COVID-19 prevention;COVID-19 treatment;Cytoplasm;Disease;Electron Microscopy;Endoplasmic Reticulum;Evaluation;Future;Genes;Genetic Transcription;Genome;genomic RNA;HIV-1;Human;human coronavirus;Image;Immune response;Impaired cognition;improved;Individual;Infection;insight;Integration Host Factors;Investigation;knock-down;Label;Lead;Length;Light;live cell imaging;Membrane;Messenger RNA;Methods;Middle East Respiratory Syndrome Coronavirus;Molecular;Molecular Virology;Mutation;new therapeutic target;Nonstructural Protein;nonsynonymous mutation;novel;novel coronavirus;Organelles;Pathway interactions;Peer Review;Peptide Hydrolases;Pneumonia;Polyproteins;post SARS-CoV-2 infection;prevent;Prevention;Process;protein expression;Proteins;Publications;receptor binding;Replication-Associated Process;Research;reverse genetics;RNA;RNA chemical synthesis;Role;SARS coronavirus;SARS-CoV-2 infection;SARS-CoV-2 variant;small molecule;spatiotemporal;superresolution imaging;superresolution microscopy;Symptoms;Time;trafficking;Translating;Translations;transmission process;ultra high resolution;Universities;Vaccines;Variant;variants of concern;Vesicle;Viral;Viral Genome;viral RNA;Virion;virology;Virulent;Virus;virus host interaction;Virus Replication;Visualization

PROJECT_TITLE: Live-cell imaging of SARS-CoV-2 replication organelle formation and RNA synthesis

STUDY_SECTION: VIRA

STUDY_SECTION_NAME: Virology - A Study Section[VIRA]


NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Colorectal Cancer;Digestive Diseases;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Microbiome;Radiation Oncology;Rare Diseases

PI_NAMEs: GOLDEN, ENCOUSE  (contact)

PROJECT_TERMS: Acceleration;Affect;Bioinformatics;Biological;Biology;Blood specimen;Cell Death;Cells;Cellular Stress;Clinical;Clinical Data;Clinical Trials;Colon;Communities;Data;data integration;data modalities;data sharing;Databases;Doctor of Philosophy;Equilibrium;fitness;Foundations;Future;Genomics;Goals;host microbiome;Image;Immune;Immune response;Immune system;Immunologics;Incidence;insight;International;international center;Intervention;Intervention Trial;Irradiated tumor;Laboratories;longitudinal analysis;lymph nodes;Magnetic Resonance Imaging;Malignant Neoplasms;Maps;microbiome;Modeling;Molecular;Molecular Analysis;Mucous Membrane;Multimodal Imaging;multiple omics;Neoadjuvant Therapy;Normal tissue morphology;novel;Operative Surgical Procedures;Outcome;Output;Oxidative Stress Induction;Pathologic;Pathway interactions;Patients;Pattern;prospective;Proteomics;Quality of Life Assessment;racial disparity;Radiation;Radiation therapy;Radio;Radiobiology;radiomics;Rectal Cancer;Research;Research Personnel;Research Priority;response;Robin bird;simulation;spatial integration;Specimen;Standardization;stool sample;Structure;Testing;Time;Tissues;tumor;Tumor Tissue;United States National Institutes of Health

PROJECT_TITLE: Molecular Characterization Trial of Irradiated Rectal Cancer


NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Biotechnology;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Patient Safety;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

PI_NAMEs: BLAIR, CINDY KAY (contact)

PROJECT_TERMS: Address;American Indian community;American Indians;Attitude;Belief;Birth;cancer diagnosis;cancer genome;cancer health disparity;Cancer Patient;Cancer Survivor;Child Health;Clinical;clinical diagnosis;Cohort Studies;Collaborations;Collection;Communication;Communities;Comprehension;Consent;Data;data anonymization;Data Protection;Data Set;data sharing;Disparity population;DNA Damage;Education;empowerment;Environmental Exposure;epidemiology study;ethnic minority;experience;genetic counselor;Genetic Research;Genome;genome sequencing;genomic data;Genomics;Goals;Health;Health Personnel;Indigenous American;Individual;Informed Consent;Intervention Studies;Intervention Trial;Knowledge;medically underserved;Methods;Modeling;Motivation;Names;Navajo;New Mexico;Outcome;Participant;patient engagement;Patient Recruitments;Patients;personalized genomics;Population;preference;Prevention;Privacy;Process;Pueblo Race;racial minority;Recording of previous events;recruit;Research;Research Personnel;Rights;scale up;Screening for cancer;social disparities;social stigma;Spirituality;Survivors;Testing;Therapeutic;Trauma;tribal community;tribal member;tribal Nation;Tribes;Trust;United States National Institutes of Health;Zinc

PROJECT_TITLE: Engagement Optimization


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Colorectal Cancer;Digestive Diseases;Genetics;Human Genome;Microbiome;Radiation Oncology;Rare Diseases

PI_NAMEs: MONTAGNA, CRISTINA  (contact)

PROJECT_TERMS: Affect;anti-cancer;anti-tumor immune response;Apoptosis;Autophagocytosis;Bacteria;beta-Galactosidase;biological adaptation to stress;Biological Assay;Biopsy;cancer cell;CASP3 gene;Cell Aging;Cell Death;Cell Death Induction;cell type;Cells;Cellular Stress;Cellular Structures;Chromosomal Instability;Clinical;Colon;Colorectal;Colorectal Cancer;Complex;Custom;Cytoprotection;Data;Detection;Diagnosis;Disease Progression;DNA Damage;DNA lesion;DNA Repair Pathway;Environment;epigenetic regulation;Excision;Exhibits;experimental study;Fostering;fungus;Future;Gene Expression;Gene Expression Profile;Genetic Transcription;Genome Stability;Genomic Instability;Growth;Heterogeneity;Histologic;histone modification;Human;Hypoxia;Immune;immune activation;immune cell infiltrate;Immune response;Immune system;Immunofluorescence Immunologic;Immunohistochemistry;Immunologist;immunoregulation;improved;innovation;innovative technologies;Invaded;Investigation;Irradiated tumor;Knowledge;Link;Malignant Neoplasms;Maps;Methodology;microbial;microbiome;microorganism;Molecular;Molecular Analysis;Monitor;Mutation;next generation sequencing;Non-Malignant;Normal Cell;novel;Oncologist;Operative Surgical Procedures;Outcome;Pathologist;Pathway interactions;Patients;Phenotype;PIK3CG gene;Population;predictive marker;Process;Proteins;radiation delivery;radiation effect;radiation response;Radiation therapy;Radiation Tolerance;Radiobiology;Radiosensitization;Rectal Cancer;Repression;Resectable;Resolution;response;RNA;Sampling;Scientist;senescence;senescent cell;Shapes;Signal Pathway;Signal Transduction;Somatic Mutation;spatiotemporal;Stains;Stress;Surgeon;Technology;Testing;therapy outcome;Time;tool;Transcript;transcriptome sequencing;transcriptomics;treatment response;tumor;Tumor Immunity;tumor microbiome;tumor microenvironment;Tumor Oxygenation;tumor-immune system interactions

PROJECT_TITLE: Analysis of the Irradiated Tumor and Tumor Microenvironment


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Methamphetamine;Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: AMHERST

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

PHR: PROJECT NARRATIVE Brain norepinephrine (NE) has been implicated in amphetamine-type stimulant (ATS) use/addiction, yet not much is known about the role of NE in ATS-induced reward and behaviors due to a limited understanding of brain NE circuits. This proposal will determine how the poorly understood and sexually dimorphic bed nucleus of the stria terminalis (BNST)-NE system contributes to methamphetamine (METH)-induced drug seeking and reinstatement using an innovative approach that incorporates chemogenetics and in vivo fast scan cyclic voltammetry. These studies will provide insights into the underlying mechanisms of ATS use and lead to novel therapeutic targets and sex specific treatment for ATS use disorder.

PI_NAMEs: PARK, JINWOO  (contact)

PROGRAM_OFFICER_NAME: NAIR, SUNILA GOPI

PROJECT_TERMS: Abstinence;Acute;addiction;Adrenergic Agents;Affinity;Amphetamines;Anatomy;Animal Model;anxiety-like behavior;Attention;Attenuated;Autoreceptors;Behavior;Behavioral;behavioral response;biological adaptation to stress;Brain;Brain Stem;Cell Nucleus;Cells;Chemosensitization;Chronic;Clinical Research;Cocaine;Complex;craving;Data;Dopamine;dopamine transporter;Dose;drug abstinence;drug seeking behavior;Drug user;Exhibits;extracellular;Female;Genetic;Goals;Human;hypothalamic-pituitary-adrenal axis;illicit drug use;in vivo;innovation;insight;Legal;Locomotion;male;Mediating;mesolimbic system;Methamphetamine;methamphetamine effect;methamphetamine exposure;methamphetamine use;Methodology;nerve supply;neuroadaptation;neurobiological mechanism;neurochemistry;Neurons;neurotransmission;new therapeutic target;noradrenaline transporter;Norepinephrine;norepinephrine system;novel therapeutics;Nucleus solitarius;Outcome;Pathway interactions;Pattern;Periodicity;Pharmaceutical Preparations;Pharmacotherapy;preclinical study;Predisposition;presynaptic;Production;psychostimulant;Public Health;Rattus;Regulation;Relapse;response;Rewards;Role;Scanning;Self Administration;sensory stimulus;sex;Sex Differences;sexual dimorphism;Signal Transduction;Stimulant;stimulant abuse;stimulant dependence;stimulant use;stimulant use disorder;stimulant user;Stimulus;Stress;stressor;Structure;Structure of terminal stria nuclei of preoptic region;Substance abuse problem;success;System;therapeutic target;Time;transmission process;treatment strategy;Up-Regulation;Withdrawal

PROJECT_TITLE: The Role of the Bed Nucleus of the Stria Terminalis-Norepinephrine System in Amphetamine-type Stimulant Use Disorders

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Colorectal Cancer;Digestive Diseases;Genetics;Human Genome;Immunotherapy;Microbiome;Radiation Oncology;Rare Diseases

PI_NAMEs: SANTAMBROGIO, LAURA  (contact)

PROJECT_TERMS: adaptive immune response;Affect;Algorithms;Anatomy;Apoptosis;B-Lymphocytes;bacterial community;Bioinformatics;Biological;Blood Cells;Blood flow;cancer cell;Cancer Control;Cancer Patient;cancer therapy;Cell Aging;Cell Death;cell type;Cells;chemotherapy;Colorectal Cancer;Data;Dendritic Cells;Development;dosage;Dose;fitness;Four-dimensional;Growth;gut microbiome;Human;Immune;immune cell infiltrate;Immune response;Immune system;Immune System Diseases;Immunologics;Immunophenotyping;Immunotherapy;imprint;improved;Inflammatory;Innate Immune Response;Intestines;Ionizing radiation;Leukopenia;longitudinal analysis;Lymph;lymph nodes;Lymphoid;Machine Learning;Macrophage;Malignant Neoplasms;Maps;Measurement;Mediating;Microbe;microbial;microbiome;microbiota;Mitochondria;Molecular;monocyte;Mucosal Immunity;Myelogenous;Natural Killer Cells;Nodal;Normal tissue morphology;Operative Surgical Procedures;Outcome;Oxidative Stress;Pathway interactions;Peripheral Blood Mononuclear Cell;Poly(A)+ RNA;Population;Pre-Clinical Model;Process;Radiation;Radiation Dose Unit;radiation effect;Radiation exposure;Radiation therapy;Rectal Cancer;response;Role;Sampling;side effect;single-cell RNA sequencing;stool sample;Stress;T-Lymphocyte;therapy outcome;Time;tool;transcriptomics;Treatment Efficacy;Treatment outcome;tumor;Tumor Immunity;tumor microenvironment;tumor progression

PROJECT_TITLE: Radiation Effect on Immune Cells and the Microbiome


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision

PI_NAMEs: SHAHIDI, MAHNAZ  (contact)

PROJECT_TERMS: Accountability;Center Core Grants;Dedications;Effectiveness;Emerging Technologies;Ensure;Fostering;Goals;Individual;Infrastructure;Lead;Monitor;new technology;novel strategies;Procedures;programs;Research;Research Personnel;Resource Sharing;Resources;Services;synergism;Vision research;vision science


ORG_CITY: MINNEAPOLIS

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: The combined and integrated efforts of the Lysosomal Disease Network focus limited resources toward creating a network of centers with expertise in these diseases in order to solve major challenges in diagnosis, disease management, and therapy. Solutions to these problems will have direct impact on patients suffering from lysosomal diseases, with important implications for medical practice and individual quality-of-life

PI_NAMEs: WHITLEY, CHESTER B. (contact)

PROGRAM_OFFICER_NAME: MORRIS, JILL A

PROJECT_TERMS: Academic support;Acceleration;Accountability;Advocate;Affect;Age of Onset;Attenuated;autosome;Beds;Biochemical;biomarker development;biomarker identification;Biometry;Birth;Cardiac;Cardiac Myocytes;Cardiovascular system;career;Career Choice;Catalogs;Categories;Central Nervous System;Characteristics;Child;Clinical;clinical investigation;clinical outcome measures;Clinical Research;clinical trial readiness;Clinical Trials;Cognition;Communities;Consent;Data;Databases;Defect;design;Development;Diagnosis;Disease;Disease Management;Disease Pathway;Disease Progression;Early Diagnosis;Early Intervention;Enrollment;Enzymes;Fabry Disease;Foundations;Framingham Heart Study;Frequencies;Functional disorder;Funding;Future;Gangliosidoses;Gangliosidosis GM1;Gene Mutation;gene therapy;gene-editing approach;Genes;genetic counselor;Genetic Engineering;Genotype;Glycogen storage disease type II;Glycoproteins;Glycosaminoglycans;Goals;Immune Tolerance;Impaired cognition;Impairment;improved;improved outcome;Incidence;Individual;Industry;information gathering;Infrastructure;Inheritance Patterns;Inherited;innovation;interest;Kidney;Knowledge;Knowledge acquisition;Life;Light;Link;lipid metabolism;Live Birth;Longitudinal Studies;Lysosomal Storage Diseases;Lysosomes;Magnetic Resonance Imaging;Medical;Metabolic;Methods;Mission;Modality;Molecular;Molecular Genetics;molecular pathology;Mucopolysaccharidoses;Mucopolysaccharidosis I;Mucopolysaccharidosis IV;Musculoskeletal;Mutation;Natural History;neglect;Neonatal Screening;Neurologic Dysfunctions;Newborn Infant;next generation;novel strategies;Nurses' Health Study;Organ;Outcome;Outcome Measure;Participant;Pathology;Pathway interactions;Patient Care;Patient-Focused Outcomes;Patients;Persons;Pharmacists;Pharmacotherapy;Phenotype;physically handicapped;Productivity;programs;prospective;Publications;Quality of life;Recommendation;Reporting;Research;Research Design;Research Personnel;Research Project Grants;Residual state;Resources;Role;Secure;Severities;Site;skeletal;Smooth Muscle Myocytes;Statistical Models;Stem cell transplant;study population;Surveys;Symptoms;System;targeted treatment;Testing;Therapeutic;Therapeutic Clinical Trial;therapeutic development;therapeutic effectiveness;Training Support;treatment response;United States National Institutes of Health

PROJECT_TITLE: Lysosomal Disease Network


NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Colorectal Cancer;Digestive Diseases;Machine Learning and Artificial Intelligence;Radiation Oncology;Rare Diseases

PI_NAMEs: DEASY, JOSEPH O (contact)

PROJECT_TERMS: Anatomy;anti-cancer research;Bioinformatics;Biological;Biology;Blood;Characteristics;Clinical Data;Collaborations;Data;Data Commons;data ecosystem;data exchange;data quality;Data Set;data sharing;Diagnostic;digital data;Digital Imaging and Communications in Medicine;Dose;Ensure;Factor Analysis;Goals;Human;Image;Immune;Immune response;Immunologic Markers;Infrastructure;innovation;insight;Learning;Link;Machine Learning;Magnetic Resonance Imaging;Maps;Methods;microbiome;Mission;Modeling;Molecular;Molecular Profiling;multimodality;Multivariate Analysis;novel;Operative Surgical Procedures;Patients;Pattern;Peripheral Blood Mononuclear Cell;Phenotype;Privatization;Publications;Radiation;Radiation therapy;radiomics;Reaction Time;Rectal Cancer;Research;Resources;Specimen;tool;Training;transcriptomics;treatment planning;tumor;X-Ray Computed Tomography

PROJECT_TITLE: Data Sharing and Integrative Analysis Core


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Mental Health;Neurosciences;Substance Misuse

ORG_CITY: Chicago

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: AUD is a debilitating neuropsychiatric disorder and the third-leading preventable cause of death in the US, yet remains without efficient treatments. The GABAergic neurosteroid, allopregnanolone (Allo) is decreased in AUD postmortem brain and in rat models of alcohol dependence. PPAR-α is an epigenetically modifiable neuronal target that regulates Allo biosynthesis and anxiety, reduces alcohol drinking, and may thus provide a pharmacological target for symptoms of alcohol withdrawal.

PI_NAMEs: PINNA, GRAZIANO  (contact)

PROGRAM_OFFICER_NAME: LORANG-LEINS, DOMINIQUE

PROJECT_TERMS: Acute;Affect;Agonist;Alcohol consumption;Alcohol dependence;alcohol effect;alcohol exposure;alcohol reward;alcohol use disorder;Alcohol withdrawal syndrome;Alcohols;Allopregnanolone;Amygdaloid structure;Anabolism;antagonist;Anti-Anxiety Agents;Anxiety;anxiety-like behavior;anxious behavior;Area;Autopsy;Basic Science;biological adaptation to stress;Biological Assay;Brain;Cause of Death;Cerebellum;Cholesterol;chromatin immunoprecipitation;Chromatin Remodeling Factor;Chronic;comorbidity;Cytosine;demethylation;DNA;DNA Methylation;DNA Modification Methylases;Dorsal;Down-Regulation;emotional behavior;Enzymes;Epigenetic Process;epigenetic regulation;Estrous Cycle;Ethanol;Ethanol dependence;FDA approved;Female;Fenofibrate;Gene Expression;Genes;Hippocampus;Human;Hydroxysteroid Dehydrogenases;Impairment;improved;Isomerism;Link;male;Mass Fragmentography;Measures;Medial;Methods;Methyl-CpG-Binding Protein 2;Methylation;Mixed Function Oxygenases;Modeling;Modification;Molecular;Mood Disorders;mRNA Expression;neural;Neurobiology;Neurons;neuropsychiatric disorder;neurosteroids;Nuclear Receptors;Nucleus Accumbens;Oxidoreductase;palmidrol;Pathway interactions;Peroxisome Proliferators;pharmacologic;Phenotype;PPAR alpha;Prefrontal Cortex;Pregnanolone;Pregnenolone;Progesterone;protein expression;Proteins;Publishing;Rattus;receptor;Regulation;Rodent;Rodent Model;Signal Transduction;Stress;Symptoms;transcription factor;transcriptomics;translational impact;translational model;vapor;Withdrawal;Withdrawal Symptom

PROJECT_TITLE: Alcohol-induced epigenetic reprogramming of PPAR-α affects allopregnanolone biosynthesis

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Brain Disorders;Hearing Loss;Infectious Diseases;Neurodegenerative;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period

ORG_CITY: SALT LAKE CITY

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE Fetal-derived resident tissue macrophages (RTMs) are pervasive cells that reside in all major tissues and acquire unique tissue-specific homeostatic roles during development; however, we have not had a direct and simple system to test the extent tissue development is educated by seeding of fetal-derived RTMs. Our preliminary data and published data indicate that RTMs in the cochlea are critical component of normal tissue development and also expand abnormally in response to congenital infection. The objective of this grant is to elucidate the role of fetal-derived RTMs in normal and abnormal cochlear development, to further define mechanisms of pathogenesis within the inner ear, and to identify RTMs as a potential novel therapeutic target for hearing loss treatment.

PI_NAMEs: OTSUKA, KELLY  (contact)

PROGRAM_OFFICER_NAME: SCHURMAN, JACLYN REBECCA

PROJECT_TERMS: Acute;Affect;Architecture;Area;Auditory system;Bone Marrow;Cell Physiology;Cells;Cochlea;cochlear development;Complex;congenital cytomegalovirus;congenital infection;Cytomegalovirus;Cytomegalovirus Infections;Data;defined contribution;Development;Disease;effective therapy;Environment;fetal;Fetal Liver;Functional disorder;Goals;Grant;hearing loss treatment;Hematopoiesis;Hematopoietic;Homeostasis;Human;Immune;Immunity;Impairment;improved;Infection;Inflammation;insight;Investigation;Label;Labyrinth;Lead;Life;life span;Link;Location;Macrophage;Maintenance;Maps;Mediating;mouse model;Mus;new therapeutic target;non-genetic;Normal tissue morphology;novel;Pathogenesis;Pathologic;Pattern;Peripheral;Phenotype;Population;postnatal;prenatal;prevent;Publishing;response;Role;Sensorineural Hearing Loss;Spatial Distribution;spatiotemporal;Symptoms;System;Testing;Time;tissue repair;Tissues;Toxoplasmosis;Viral;Work;Yolk Sac

PROJECT_TITLE: The role of resident tissue macrophages in cytomegalovirus-associated sensorineural hearing loss


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Eye Disease and Disorders of Vision;Nanotechnology

PI_NAMEs: ZHOU, QIFA  (contact)

PROJECT_TERMS: Acceleration;Anterior;Basic Science;Biological;Biological Products;Cellular biology;Center Core Grants;Chemicals;Computers and Advanced Instrumentation;Consultations;Coupled;Custom;delivery vehicle;design;Development;Devices;Drug Delivery Systems;elastography;Engineering;Experimental Designs;Eye;Eye diseases;Formulation;improved;innovation;innovative technologies;instrument;instrumentation;investigator training;mechanical device;Mechanics;Microfabrication;Molecular;nanoassembly;nanomedicine;novel;novel therapeutic intervention;novel therapeutics;Ocular Physiology;operation;Pharmaceutical Preparations;Play;Procedures;programs;Research;Research Personnel;Research Project Grants;Resources;Role;Services;Site;Structure;targeted delivery;Technical Expertise;Techniques;Technology;technology research and development;Therapeutic;translational scientist;ultrasound;Vision research;vision science

PROJECT_TITLE: Ophthalmic Therapeutics Engineering Core


NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Drug Abuse (NIDA only);Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Racial and Ethnic Minority Health Research;Recovery Support Services;Substance Misuse

PI_NAMEs: LAPLANTE, DEBI A (contact)

PROJECT_TERMS: addiction;Administrative Coordination;Adult;Alaska Native;American Indians;Collaborations;Communication;Communities;cultural health;Decision Making;design;Development;Ensure;experience;Face;Faculty;Feedback;Fostering;Funding;Future;Goals;Grant;Health;Human Resources;human subject;implementation facilitation;Indigenous;Individual;Infrastructure;innovation;insight;interest;Joints;Knowledge;Learning;learning materials;Logic;Mental Health;Mentors;Modeling;Native American Research Center for Health;operation;Outcome;Output;Performance;Pilot Projects;Process;process evaluation;programs;Recovery;relapse prevention;Reporting;Research;Research Personnel;Research Project Grants;Resources;response;Science;Services;Site;skills;social stigma;Structure;Students;Support System;System;Techniques;Technology;Time;tool;Training;training opportunity;tribal community;Tribal Council;tribal Nation;Tribes;Work;Workplace;Youth

PROJECT_TITLE: Assessing Cultures of Recovery in Tribal Communities - Administrative Core

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BDCN-N]


NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Substance Misuse

PI_NAMEs: NELSON, SARAH E (contact)

PROJECT_TERMS: addiction;Addictive Behavior;Adolescent;Adult;Alaska Native;American Indian Population;American Indians;Authorization documentation;Award;Behavior;behavioral health;Belief;Collaborations;Communities;community research;Community Surveys;control trial;curriculum enhancement;design;Educational Curriculum;Effectiveness;Enrollment;ethnic minority population;experience;Face;Feedback;follow-up;Future;Goals;healing;Health;Health Resources;Health Services Accessibility;health training;help-seeking behavior;Incidence;Indigenous;Individual;Knowledge;Learning;long term recovery;Measures;member;Mental Health;Modification;Native American Research Center for Health;Participant;Perception;Population;Prevalence;prevent;Prevention;Program Evaluation;psychosocial;racial minority population;Randomized;Records;Recovery;Research;research data dissemination;Research Design;Resources;Social isolation;social stigma;Surveys;Time;Training;Training Activity;Training Programs;tribal community;Tribal Council;tribal Nation;Tribally Based Participatory Research;Tribes;United States;Waiting Lists;Work;working group;Youth

PROJECT_TITLE: Assessing Cultures of Recovery in Tribal Communities - Research Core


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Data Science;Eye Disease and Disorders of Vision;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

PI_NAMEs: HAMM-ALVAREZ, SARAH F (contact)

PROJECT_TERMS: advanced analytics;Algorithmic Software;analytical tool;Artificial Intelligence;artificial intelligence algorithm;Biological;cell preparation;cellular imaging;Center Core Grants;Confocal Microscopy;Consultations;cost;Coupled;Data;Data Science Core;Development;Electron Microscopy;Equipment;Evaluation;Experimental Designs;Goals;Histology;Image;Image Analysis;imaging modality;imaging science;imaging system;implementation tool;Individual;innovation;investigator training;light microscopy;live cell imaging;Machine Learning;Methodology;Microscopic;Microscopy;operation;Productivity;Research;Research Personnel;Research Project Grants;Resources;Services;Specimen;Technical Expertise;Techniques;Technology;Tissue imaging;tissue preparation;Tissues;Vision research;vision science

PROJECT_TITLE: Cell & Tissue Imaging and Data Science Core


ORG_CITY: LITTLE ROCK

ORG_NAME: ARKANSAS CHILDREN'S HOSPITAL RES INST

ORG_STATE: AR

PHR: PROJECT NARRATIVE The goal of the Center for Childhood Obesity Prevention is to establish a broad-based, multi-disciplinary disease prevention center, rooted in a team science approach and spanning the full translational spectrum, to bring together research in complex disease origins, epidemiology, and social systems to address the childhood obesity crisis. Efforts will continue to build state-of-the-art institutional biomedical research infrastructure to support this goal, as well as continuing to build and train a critical mass of scientists focused on creating the base of evidence for strategies to improve child health.

PI_NAMEs: BORSHEIM, ELISABET  (contact)

PROGRAM_OFFICER_NAME: CUPIT, PAULINE

PROJECT_TERMS: 4 year old;Address;Adolescent;Adolescent obesity;Arkansas;Asthma;Behavior;Biomedical Research;Burn injury;cardiorespiratory fitness;career development;Caring;Child;Child Health;Classification;Clinical;Collaborations;Communities;community partners;comorbidity;Complex;Contracts;Development;Diabetes Mellitus;dietary;Dietary Proteins;Disease;disorder prevention;Education;Emotional;energy balance;Energy Metabolism;Ensure;Environment;Epidemiology;evidence base;Evidence based practice;exercise intensity;fitness;Food;fundamental research;Goals;Health;Hypertension;improved;innovation;Institution;Insulin Resistance;Intervention;Investments;Leadership;Link;Low income;Maintenance;Malignant Neoplasms;Mentors;Metabolic;metabolic rate;Mitochondria;Modeling;multidisciplinary;Muscle function;non-alcoholic fatty liver disease;Obesity;obesity in children;obesity prevention;operation;Outcome;Overweight;overweight child;Pathway interactions;Phase;Phenotype;Physical activity;Pilot Projects;Policies;Population;Prevalence;Prevention strategy;Problem behavior;Procedures;Process;Program Development;programs;protein intake;Protons;Public Health;Recommendation;recruit;Regulation;Research;research facility;Research Infrastructure;Research Institute;Research Personnel;Research Project Grants;Resources;Rights;Role;Sampling;School-Age Population;Schools;Science;Scientist;Secure;Series;severe burns;Sleep Disorders;social;Strategic Planning;System;Teacher Professional Development;Testing;Time;Training;Training Programs;translational pipeline;United States;United States National Institutes of Health;Work;Youth

PROJECT_TITLE: Center for Childhood Obesity Prevention


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: PROVIDENCE

ORG_NAME: PROVIDENCE VA  MEDICAL CENTER

ORG_STATE: RI

PHR: Diabetes is a common chronic disease in the U.S. veteran population, and non-healing skin wounds are a major cause of loss of limb and debility for veterans with diabetes. Current medical treatments have limited effectiveness at healing wounds because it is not entirely clear how diabetes impairs the healing process. The primary goal of these studies is to identify inflammation signals that direct the early growth of new blood vessels to help with healing. By understanding these mechanisms, we believe these studies will lead to new therapies that promote more effective skin healing and limb salvage for veterans and all patients with diabetes.

PI_NAMEs: MORRISON, ALAN ROSS (contact)

PROJECT_TERMS: Acute;Aging;American;Amputation;angiogenesis;Angiogenesis Inhibitors;Animals;Anti-Inflammatory Agents;Area;autocrine;Binding;Blood Glucose;Blood Vessels;Bone Marrow;Bone Marrow Involvement;Bypass;Caring;cell type;Cells;chemokine receptor;Chronic;Chronic Disease;Complex;cytokine;Data;Debility;Debridement;Dermal;Diabetes Mellitus;diabetic;Diabetic mouse;Disease;Effectiveness;Endothelial Cells;Experimental Diabetes Mellitus;femoral artery;Fibroblast Growth Factor;Financial Hardship;Genetic Transcription;Goals;Growth Factor;healing;health care service utilization;Healthcare Systems;IL1R1 gene;Immune;Impaired healing;Impaired wound healing;Impairment;improved;Individual;Infection;Infection Control;Inflammation;Inflammatory;Inflammatory Infiltrate;Inflammatory Response;Injury;Integrins;Interleukin-1 beta;Lead;Leg Ulcer;Ligation;limb ischemia;limb loss;Limb Salvage;Macrophage;Mechanics;Medical;military veteran;Modeling;Molecular;monocyte;Morbidity - disease rate;mortality;Mus;necrotic tissue;new growth;NF-kappa B;novel strategies;novel therapeutics;Nuclear;Operative Surgical Procedures;Osteomyelitis;Pathway interactions;patient subsets;Patients;Perfusion;Peripheral arterial disease;Platelet-Derived Growth Factor;preclinical study;prevent;Process;Production;programs;promoter;Protein Isoforms;Punch Biopsy;Recovery;Research;response;revascularization;Role;Signal Transduction;skin healing;skin wound;Smooth Muscle Myocytes;Source;standard of care;STAT3 gene;Stents;Therapeutic;Thick;Tissues;Ulcer;Up-Regulation;Vascular Diseases;Vascular Endothelial Growth Factors;VEGFA gene;Veterans;wound healing

PROJECT_TITLE: Reprogramming Macrophages to Improve Vascular Healing in Diabetes


NIH_SPENDING_CATS: American Indian or Alaska Native;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Racial and Ethnic Minority Health Research;Rural Health;Substance Misuse

PI_NAMEs: EDSON, TIMOTHY C (contact)

PROJECT_TERMS: Active Learning;addiction;Admission activity;Adolescent;Affect;Aftercare;Age;Alaska Native;American Indians;Authorization documentation;Award;Characteristics;Charge;Clinical;Clinical Research;Clinical Services;clinically relevant;cohort;Collaborations;Communities;Community Healthcare;Consultations;Coping Skills;Data;demographics;design;early onset substance use;Emotional;Ensure;Environmental Risk Factor;experience;Exposure to;Feedback;Foundations;Funding;Future;Gender;Goals;healing;health disparity;Health Status;Home;Indian reservation;Indigenous;innovation;Institution;instrumentation;Intake;interest;Intervention;Knowledge;knowledge translation;Leadership;Learning;learning strategy;Life;Measures;meetings;member;Mental disorders;multiple drug use;Native American Research Center for Health;native youth;Native-Born;Patient Self-Report;Persons;Pilot Projects;pressure;Prevalence;protective factors;psychiatric comorbidity;Recording of previous events;Records;Recovery;Relapse;relapse prevention;Research;research and development;research data dissemination;research study;Reservations;residence;Residential Treatment;Resource Development;Risk Factors;social;Source;Specialist;Subgroup;substance misuse;substance use;Substance Use Disorder;substance use treatment;Surveys;Time;Training;tribal community;Tribal Council;tribal Nation;Tribally Based Participatory Research;Tribes;United States Indian Health Service;Walking;Work;working group;Youth

PROJECT_TITLE: Assessing Cultures of Recovery in Tribal Communities - Pilot Project 1: Understanding Relapse among Tribal Youth


NIH_SPENDING_CATS: Biomedical Imaging;Eye Disease and Disorders of Vision

PI_NAMEs: THOMAS, BIJU BLAVADY (contact)

PROJECT_TERMS: Acceleration;Address;Animal Disease Models;Animal Model;Basic Science;Center Core Grants;Consultations;cost;Coupled;Development;Equipment;Evaluation;Experimental Animal Model;Eye diseases;Genotype;Harvest;Image;Imaging Techniques;in vivo;in vivo imaging;Individual;instrument;instrumentation;investigator training;Molecular;novel diagnostics;novel therapeutic intervention;ocular imaging;operation;Operative Surgical Procedures;Process;Qualifying;Research;Research Personnel;Resources;Sampling;Signs and Symptoms;Structure;Technical Expertise;Technology;Testing;Therapeutic;Tissues;Training;Translations;Vision;Vision research;vision science

PROJECT_TITLE: Animal Models and In Vivo Imaging Core


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

ORG_CITY: RICHARDSON

ORG_NAME: UNIVERSITY OF TEXAS DALLAS

ORG_STATE: TX

PHR: The goal of this project is to create the scientific foundation that will empower pain researchers around the world to approach the problem of treating pain in a new way, deeply rooted in a fundamental understanding of the first neurons and first synapses in the human pain pathway. Our Center will identify molecular phenotypes, using single cell and spatial transcriptomic technologies, of human sensory neurons from the dorsal root ganglion (DRG) and spinal dorsal horn neurons and cells in organ donor recovered tissues and in patients suffering from chronic pain. We envision creating actionable knowledge and data resources that can transform our understanding of human pain conditions.

PI_NAMEs: CURATOLO, MICHELE ;DOUGHERTY, PATRICK M;PRICE, THEODORE J. (contact)

PROGRAM_OFFICER_NAME: MOHAPATRA, DURGA PRASANNA

PROJECT_TERMS: Adult;Afferent Neurons;Animal Model;Animals;Architecture;Biological Assay;Brain;Cancer Center;Cell Nucleus;cell type;Cells;Chest;Chronic disabling pain;Chronic low back pain;Chronic neck pain;chronic pain;chronic painful condition;Collaborations;Communication;Complex;conflict resolution;connectome;Data;data resource;Disabling;Disease;dorsal horn;empowerment;Ensure;Foundations;Generations;Genome;Genomics;Goals;Human;human tissue;Immunohistochemistry;Individual;Information Resources;insight;life span;Low Back Pain;Maps;Methods;Microfluidics;Modeling;Molecular;Molecular Analysis;molecular phenotype;Molecular Profiling;Mus;Nature;Nerve;Neurons;Nociception;Nociceptors;nonhuman primate;Operative Surgical Procedures;Organ Donor;Pain;Pain management;pain patient;pain perception;painful neuropathy;Pathway interactions;Patients;Peripheral;Peripheral Nerves;Pharmacology;Physiological;Population Heterogeneity;Posterior Horn Cells;Price;Process;Productivity;Protocols documentation;Publications;Publishing;Quality Control;Research Personnel;Research Project Grants;Resolution;Resources;ribosome profiling;RNA;Sampling;sex;Sex Differences;Signal Transduction;Spinal;Spinal Cord;Spinal Ganglia;Split-Pool Ligation Transcriptome sequencing;success;Synapses;Techniques;Technology;Therapeutic;tissue processing;Tissue Procurements;Tissues;transcriptome;transcriptome sequencing;transcriptomics;Translations;Universities;Washington;Work

PROJECT_TITLE: Human Nociceptor and Spinal Cord Molecular Signature Center


NIH_SPENDING_CATS: American Indian or Alaska Native;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Drug Abuse (NIDA only);Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Racial and Ethnic Minority Health Research;Substance Misuse

PI_NAMEs: GRAY, HEATHER M (contact)

PROJECT_TERMS: Active Learning;addiction;Address;Alaska Native;Alaska Native population;American Indians;Authorization documentation;Back;Beds;behavioral health;Clinical;Clinical Research;clinical training;clinically relevant;college;Communities;community building;Data Collection;Dedications;design;Development;Drug Addiction;Education;Ensure;Evaluation;experience;Face;Goals;graduate student;healing;Health;health communication;health disparity;improved;Institution;interest;knowledge translation;Leadership;Learning;learning strategy;member;Mental Health;Methods;Native American Research Center for Health;Native Americans;Newsletter;Oral health;Personal Satisfaction;Pilot Projects;Positioning Attribute;Preparation;Process;programs;public health research;Recovery;Research;Research Assistant;research data dissemination;Research Personnel;Residential Facilities;Resources;Scientist;Seasons;Series;skills;Students;Substance Use Disorder;Supervision;Time;Trainers Training;Training;Training Activity;Training Programs;tribal community;Tribes;undergraduate student;Universities;Visual;Work;Writing;Youth

PROJECT_TITLE: Assessing Cultures of Recovery in Tribal Communities - Capacity Building Core


NIH_SPENDING_CATS: Genetics;Neurosciences;Rare Diseases

PROJECT_TERMS: Advisory Committees;Advocacy;Affect;Age of Onset;Attenuated;autosome;Biochemical;Birth;career;Categories;Characteristics;Clinical;Communication;data management;Defect;Disease;Early Diagnosis;Ensure;Enzymes;Fellowship;Frequencies;Gangliosidoses;Gene Mutation;gene therapy;gene-editing approach;Genes;Genotype;Glycoproteins;Glycosaminoglycans;Goals;Group Affiliation;Human Resources;improved outcome;Incidence;Individual;Inheritance Patterns;Inherited;Institutional Review Boards;Life;Link;lipid metabolism;Live Birth;Lysosomal Storage Diseases;Lysosomes;meetings;Metabolic;Mucopolysaccharidosis I;Mutation;Neurologic Dysfunctions;Newborn Infant;next generation;Occupational activity of managing finances;Office of Administrative Management;Online Systems;Outcome Study;Participant;patient advocacy group;Patient Recruitments;Persons;Pharmacotherapy;Phenotype;Pilot Projects;Principal Investigator;programs;Protocols documentation;Research;Research Project Grants;Research Support;Scientist;Severities;Stem cell transplant;Structure;success;Symptoms;Therapeutic;web site;Work

PROJECT_TITLE: Lysosomal Disease Network Administrative Core


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Childhood Obesity;Nutrition;Obesity;Pediatric;Prevention

PI_NAMEs: WEBER, JUDITH LYNNE (contact)

PROJECT_TERMS: Advisory Committees;Award;Bioenergetics;Biostatistics Core;Budgets;career development;community engagement;comorbidity;Data;design;Development;Effectiveness;Evaluation;Extramural Activities;Faculty;Funding;Growth;Infrastructure;Institution;Intervention;Investments;meetings;Mentors;Metabolism;Mission;Names;obesity in children;obesity prevention;operation;Phase;Pilot Projects;prevent;Process;programs;Progress Reports;Publications;recruit;Regulation;Research;Research Infrastructure;Research Personnel;Research Project Grants;Research Support;Science;Scientific Inquiry;Scientist;synergism;Testing;Training and Education;Visit;Work

PROJECT_TITLE: Center for Childhood Obesity Prevention - Administrative Core


NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Clinical Research;Neurosciences;Orphan Drug;Pediatric;Pediatric Cardiomyopathy;Prevention;Rare Diseases

PI_NAMEs: KISHNANI, PRIYA S. (contact)

PROJECT_TERMS: Academic skills;Affect;Antibody Response;Antibody titer measurement;Audiology;Autopsy;Behavior;Biochemical;Bortezomib;Brain;Brain imaging;brain magnetic resonance imaging;Brain region;Cardiomyopathies;CD19 gene;Central Nervous System;Clinic Visits;Clinical;clinical diagnosis;clinically significant;Cognition;Cognitive;cognitive function;cognitive testing;cohort;Collaborations;cross reactivity;Data;Deglutition;Deposition;Development;Diagnosis;Dimensions;Disease;disease diagnosis;Dose;Early Diagnosis;Early identification;Education;Electrophysiology (science);enzyme replacement therapy;Enzymes;Evaluation;evidence based guidelines;executive function;Fiber;follow-up;Future;Glucan 1,4-alpha-Glucosidase;Glycogen;Glycogen storage disease type II;Hearing;Hearing Tests;Heart;Hypertrophic Cardiomyopathy;Immune response;Immune Tolerance;Immunoglobulin G;Immunologic Markers;Immunologics;Impairment;improved;indexing;Individual;infancy;Infection;insight;Intravenous Immunoglobulins;Investigation;Knowledge;Laboratories;Language;Left Ventricular Mass;Life;Longterm Follow-up;Lysosomal Storage Diseases;Measures;Methotrexate;Motor;Multicenter Studies;Muscle;Natural History;Neonatal Screening;Nervous System;neuroimaging;Neurologic;Neurologic Effect;Neuropathy;Outcome;Pathology;Patient-Focused Outcomes;Patients;Peripheral Nervous System;Phenotype;Physical therapy;Plasma Cells;prevent;prophylactic;Protocols documentation;Questionnaires;Regimen;Reporting;Residual state;response;rituximab;Role;Safety;safety assessment;Sleep;Speech;Structure;Survivors;Symptoms;Teenagers;Testing;Therapeutic;Therapy Evaluation;Time;Treatment outcome;treatment response;ultrasound;Vaccination;Vaccines;Western Blotting;white matter change

PROJECT_TITLE: Long Term Follow-up and Treatment Outcomes for Individuals with Pompe Disease


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: WASHINGTON

ORG_NAME: CHILDREN'S NATIONAL MEDICAL CENTER

ORG_STATE: DC

PHR: PROJECT NARRATIVE The Perinatal Mood and Anxiety Disorder Learning Laboratory at Children’s National will redesign postpartum maternal mental health care, develop new technology for patient-provider communication, allow benchmarking and systems monitoring, and evaluate system threats and costs. This is a critical next step that brings us closer to new comprehensive, point-of-care maternal mental health care models on a large scale. The project is relevant to AHRQ’s call for using systems engineering approaches by multidisciplinary healthcare teams to test innovative solutions that improve quality and can be replicated and disseminated to improve outcomes for mothers and infants.

PI_NAMEs: HOSSEINICHIMEH, NIYOUSHA ;SOGHIER, LAMIA  (contact)

PROGRAM_OFFICER_NAME: GRIPIOTIS, EROFILE

PROJECT_TITLE: Perinatal Mood and Anxiety Learning Laboratory in a Freestanding Children's Hospital

STUDY_SECTION: HSQR

STUDY_SECTION_NAME: Healthcare Patient Safety and Quality Improvement Research[HSQR]


NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Heart Disease;Kidney Disease;Neurodegenerative;Neurosciences;Orphan Drug;Pediatric;Rare Diseases

PI_NAMEs: MAUER, S. MICHAEL (contact)

PROJECT_TERMS: Age;age effect;Alpha-galactosidase;Apoptosis;Autonomic Dysfunction;Biological Assay;Biopsy;Blood Pressure;blood pressure variability;Blood Vessels;Cardiac;Cardiac Myocytes;Cardiomyopathies;Cardiovascular system;Cause of Death;cell type;Cells;Clinical;clinical decision-making;Clinical Trials;Clinical Trials Design;Collection;Complication;Development;Disease;Dose;Dysautonomias;Effectiveness;EFRAC;Electrocardiogram;End stage renal failure;enzyme replacement therapy;Enzymes;Event;Fabry Disease;Female;Fibrosis;Functional disorder;Future;globotriaosylceramide;glomerulosclerosis;Grant;Half-Life;Heart;Heart failure;heart function;Heart Rate;heart rate variability;Histology;Hypertrophy;Image;improved;insight;interstitial;Kidney;kidney biopsy;Kidney Diseases;Kidney Failure;Lesion;Long-Term Effects;Lysosomal Storage Diseases;male;mortality;Natural History;novel;novel strategies;novel therapeutic intervention;Organ;Patients;Pilot Projects;podocyte;Proteinuria;Rare Diseases;Renal function;Reproducibility;Research Personnel;Residual state;Resistance;response;Risk;Severities;sex;Skin;skin biopsy;Smooth Muscle Myocytes;Specimen;standard care;Stroke;Testing;therapy resistant;Tissues;tool;treatment guidelines;Treatment outcome;treatment response;Vascular Smooth Muscle;Ventricular

PROJECT_TITLE: Cardiac and Arteriolar Lesions in Fabry Disease and Dysautonomia


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Prostate Cancer;Radiation Oncology;Urologic Diseases

ORG_CITY: SEATTLE

ORG_DEPT: UROLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: PROJECT NARRATIVE Prostate cancer (PCa) is the most common non-skin cancer among American men. The proposed work will benefit public health by advancing a new HIFU technology, histotripsy, for transrectal non-thermal ablation of prostate cancer to provide a non-invasive, effective focal therapy of PCa with reduced side effects compared to standard treatment options.

PI_NAMEs: SCHADE, GEORGE R (contact)

PROGRAM_OFFICER_NAME: BUCHSBAUM, JEFFREY

PROJECT_TERMS: Ablation;Acoustics;active method;Acute;Aftercare;Algorithms;American;Biopsy;Cancer Control;canine model;Canis familiaris;Cell Death;Chronic;Clinical;clinical implementation;Clinical Trials;Coagulative necrosis;Data;design;Devices;Diffusion;elastography;Electronics;Elements;Ensure;FDA approved;Feedback;flexibility;Focused Ultrasound Therapy;Freezing;Frequencies;Funding;Future;Geometry;Grant;Heating;Holography;Image;Image Enhancement;image guided;imaging capabilities;imaging probe;improved;in vivo;interest;Intestines;Lesion;Localized Disease;Localized Malignant Neoplasm;Location;Magnetic Resonance Imaging;Malignant - descriptor;Malignant neoplasm of prostate;Malignant Neoplasms;Measurement;Mechanics;men;Methods;millisecond;Monitor;Morbidity - disease rate;Motion;neurovascular;Non-linear Models;novel;Operative Surgical Procedures;Organ;Outcome;patient population;Patients;Physiologic pulse;pre-clinical;Preparation;Prostate;Prostate Ablation;prostate cancer model;Prostate Cancer therapy;Protocols documentation;prototype;Public Health;Quality of life;Radiation therapy;Radical Prostatectomy;Rectum;Reporting;Reproducibility;research clinical testing;Safety;Series;Shock;side effect;simulation;Solid;sound;Specimen;Sphincter;standard care;Structure;success;System;Techniques;Technology;Testing;Thermal Ablation Therapy;Time;tissue phantom;Tissues;Transducers;Translating;Translations;Transrectal High-Intensity Focused Ultrasound;Treatment Protocols;tumor;Tumor Volume;Ultrasonography;ultrasound;urinary;Work

PROJECT_TITLE: Transrectal Histotripsy for Focal Ablation of Prostate Cancer


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Clinical Research;Disability Research;Genetics;Intellectual and Developmental Disabilities (IDD);Mucopolysaccharidoses (MPS);Neurosciences;Orphan Drug;Pediatric;Rare Diseases;Transplantation

PI_NAMEs: WHITLEY, CHESTER B. (contact)

PROJECT_TERMS: Address;Adolescent;Adult;Affect;Age;Aging;aspirate;Behavioral;Biological Markers;Biopsy;Birth;Blood;Body System;bone;Bone Development;Brain;Brain Diseases;burden of illness;Canada;Cardiac;Cardiopulmonary;Cartilage;Catabolism;Categories;Cell Cycle Progression;Cell Cycle Regulation;Cells;cellular pathology;Central Nervous System;Cervical;Cessation of life;Child;Childhood;Clinical;clinical trial readiness;Cognitive;Data;Data Set;Defect;Deposition;design;Development;Diagnosis;Dimensions;disability;disability impact;Disabling;Disease;Disease Pathway;disorder subtype;DNA;DNA Sequence Alteration;Early treatment;efficacious treatment;Emotional;falls;Family;Foundations;Future;gene therapy;Genetic;Genotype;Geography;Glycosaminoglycans;heart function;Hematopoietic Stem Cell Transplantation;Hereditary Disease;Heritability;Hydrocephalus;Impaired cognition;in utero;Incidence;Individual;infancy;Infant;innovation;Joints;Life;life span;Lifelong disability;Longitudinal Studies;Lung;Lysosomal Storage Diseases;Measurement;Measures;Methodology;Modality;Modeling;molecular pathology;Morbidity - disease rate;morphometry;mortality;Mucopolysaccharidoses;Mucopolysaccharidosis I;Mucopolysaccharidosis I H;Mucopolysaccharidosis IV;Mucopolysaccharidosis VI;multidimensional data;Mutation;Natural History;Neonatal Screening;Nervous System Trauma;Neurocognition;Neurocognitive;neurodevelopment;neuroimaging;novel therapeutics;Organ;Orthopedic Surgery;Osteitis;Outcome;Outcome Measure;Pathology;Pathway interactions;patient population;Patients;Pattern;Phenotype;Physical Function;physical symptom;physically handicapped;Population;premature;Prospective Studies;psychosocial;Psychosocial Influences;psychosocial outcome;pulmonary function;Quality of life;Recommendation;Recording of previous events;Research;Severities;Siblings;Signal Pathway;skeletal;social;Standardization;Stem cell transplant;Structure;Survival Rate;Survivors;Synovial Fluid;Synovial Membrane;System;Testing;Therapeutic;therapy outcome;therapy resistant;Time;Toxic effect;Transplantation;transplantation therapy;treatment and outcome;Umbilical cord structure;white matter

PROJECT_TITLE: MPS Disease Longitudinal Study of Treatment and Outcomes Across the Lifespan


PI_NAMEs: BROWN, ANDREW W (contact)

PROJECT_TERMS: Address;Applications Grants;Arkansas;Awareness;Biometry;Biostatistics Core;career;Centers of Research Excellence;Child;cohesion;Collaborations;Communication;community engagement;community involvement;Data;Data Analyses;data resource;Data Set;Databases;Dedications;design;detection limit;Development;Discipline;Education;Educational Activities;Ensure;expectation;experience;Extramural Activities;Foundations;Government;Human;improved;Individual;Infrastructure;Institution;Medical;member;Mentors;metabolic abnormality assessment;Methodology;Mission;obesity in children;obesity prevention;Outcome Measure;Phase;Pilot Projects;Play;Preparation;Prevention;Prevention Research;Process;programs;Publications;Research;Research Activity;Research Design;Research Institute;Research Personnel;Research Project Grants;research study;Resources;Role;Science;Solid;Source;statistics;timeline;Training;Training Activity;Training and Education;training opportunity;translational pipeline;Universities

PROJECT_TITLE: Center for Childhood Obesity Prevention - Biostatistics Core


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Genetics;Hematology;Lung;Lung Cancer;Lymphatic Research;Lymphoma;Pancreatic Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_NAME: FRED HUTCHINSON CANCER CENTER

PHR: The Myc protein is an essential regulator of growth in all normal cells, but in many cancers Myc is escapes normal controls and supports high rates of growth needed for tumor progression. In this proposal we will determine what events contribute to activation of Myc in tumors and devise approaches to inhibit Myc function. This research is relevant to public health because it will ultimately lead a better understanding of the causes for cancer and provide new approaches to cancer therapy.

PI_NAMEs: EISENMAN, ROBERT NEIL (contact)

PROGRAM_OFFICER_NAME: GHOSH-JANJIGIAN, SHARMISTHA

PROJECT_TERMS: Apoptosis;Automobile Driving;B-Cell Lymphomas;Binding;biological systems;Cancer Etiology;cancer therapy;cell growth;cell motility;Cell Proliferation;Cells;chromatin modification;Complex;Data;Dimerization;DNA;DNA Binding;DNA Binding Domain;Event;Functional dependence;Gene Expression;Genes;Genetic Transcription;Growth;Hematopoiesis;hematopoietic stem cell self-renewal;Heterodimerization;Higher Order Chromatin Structure;Human;In Vitro;Lead;loss of function;Lung Adenocarcinoma;Lymphoma;Malignant Neoplasms;MAX gene;Mediating;member;Metabolic;Metabolism;Molecular;Mus;Mutation;MYC Family Protein;MYC gene;Neoplasm Metastasis;Neoplasms;Normal Cell;novel strategies;novel therapeutic intervention;Oncogenic;Pancreatic Adenocarcinoma;Phenotype;Point Mutation;Production;programs;Proliferating;Proteins;Proto-Oncogene Proteins c-myc;Public Health;Regulation;Research;Resistance;Role;transcription factor;transcriptional reprogramming;tumor;tumor initiation;tumor progression;Tumor Suppression

PROJECT_TITLE: The MYC Transcription Factor Network and the Path to Cancer


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Orphan Drug;Rare Diseases

PROJECT_TERMS: Area;Biological Markers;Clinical;clinical trial readiness;Clinical Trials;Data;design;Disease;Disease Progression;Fostering;Foundations;Funding;Funding Mechanisms;Goals;Grant;Infrastructure;innovation;instrument;Knowledge;Lysosomal Storage Diseases;Methods;Mission;Monitor;Natural History;Neonatal Screening;novel therapeutics;Outcome;phase I trial;Pilot Projects;Research;Research Personnel;Research Project Grants;Sorting;Technology;Testing;Time;Treatment outcome;Writing

PROJECT_TITLE: Lysosomal Disease Network Pilot Core


PROJECT_TERMS: Biochemical;Biochemical Process;career;career awareness;career development;career networking;Cell Physiology;Cells;Childhood;Clinical;Clinical Research;Communities;Development;Diagnosis;Diagnostic;Disease;DNA analysis;Education;educational resource development;Endosomes;Enzymes;family burden;Fellowship;Fostering;Genetic;genetic technology;Genotype;Goals;improved;Individual;interest;Investigation;Investments;Journals;Knowledge;Lysosomal Storage Diseases;Lysosomes;Medical;meetings;Neonatal Screening;Pathogenesis;Peer Review;Phenotype;Physiological;Postdoctoral Fellow;Process;Publishing;Qualifying;Rare Diseases;Research;Research Personnel;Research Project Grants;System;Techniques;Technology;Thinking;Time;tool;Training

PROJECT_TITLE: Career Enhancement Core


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Chronic Pain;Eye Disease and Disorders of Vision;Mental Health;Nanotechnology;Neurosciences;Opioids;Pain Research;Sleep Research

ORG_CITY: FORT COLLINS

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: COLORADO STATE UNIVERSITY

ORG_STATE: CO

PHR: Project Narrative Long-term opioid treatment of chronic pain (CP) patients is associated with worsening sleep deficiencies, expressed as inadequate sleep duration and daytime sleepiness. Importantly, opioid-induced sleep disruptions decrease pain tolerance, increase vulnerability for addiction and might trigger suicidal ideations. We will study a novel, neuronal pathway that contributes to these important adverse opioid effects and investigate if this pathway might be therapeutically targeted to reduce the severity and inherent comorbidities of sleep disorders in patients receiving long-term opioid therapies.

PI_NAMEs: VIGH, JOZSEF  (contact)

PROGRAM_OFFICER_NAME: WRIGHT, CHARLES BAKER

PROJECT_TERMS: ABCB1 gene;addiction;Address;adeno-associated viral vector;Adenylate Cyclase;Affect;Agonist;Analgesics;antagonist;Artificial nanoparticles;Behavior;Behavioral;behavioral sensitization;biomaterial compatibility;Blood;Blood - brain barrier anatomy;Blood-Retinal Barrier;Brain;Cells;chemical binding;Chronic;chronic pain management;chronic pain patient;circadian pacemaker;comorbidity;Competitive Binding;connective tissue-activating peptide;Consensus;copolymer;Coupled;Coupling;Cyclic AMP;Darkness;Data;Deposition;Development;Devices;Diclofenac;Dose;Drowsiness;Drug Delivery Systems;Drug Kinetics;Electroencephalography;Electrophysiology (science);Encapsulated;endogenous opioids;Etiology;Eye;Feeling suicidal;Grant;GTP-Binding Proteins;Human;Image;improved;insight;inward rectifier potassium channel;Kinetics;Light;Mammals;Measures;Mediating;melanopsin;Micelles;Molecular;Morphine;Mus;Naloxone;nanoparticle;Neural Pathways;Neurons;neuroregulation;novel;Opioid;opioid abuse;Opioid Analgesics;Opioid Receptor;opioid therapy;Pain Threshold;patch clamp;Pathway interactions;Patients;pharmacologic;polysubstance use;Preparation;Process;psychiatric comorbidity;Reporter;response;Retina;Retinal Ganglion Cells;Schedule;Severities;side effect;Signal Transduction;Site;Sleep;Sleep Deprivation;Sleep Disorders;Sleep disturbances;Sleep Wake Cycle;Sleeplessness;Substance Use Disorder;System;Telemetry;Testing;Therapeutic;therapeutic target;tool;trafficking;Training;Transfection;Up-Regulation;voltage;Work

PROJECT_TITLE: Opioid Modulation of Retinal Ganglion Cells Providing Photoentrainment of the Circadian Clock

STUDY_SECTION: BNRS

STUDY_SECTION_NAME: Behavioral Neuroendocrinology, Neuroimmunology, Rhythms, and Sleep Study Section [BNRS]


PI_NAMEs: PRICE, THEODORE J. (contact)

PROJECT_TERMS: Achievement;Architecture;cell type;chronic pain patient;Collaborations;Communication;conflict resolution;Data;data centers;data management;data portal;Data Set;Elements;experience;Funding;Geography;Goals;Grant;Guidelines;Human;human tissue;Institution;Intellectual Property;Laboratories;Maps;material transfer agreement;meetings;member;Methods;Molecular;Molecular Profiling;Monitor;Neurons;Nociceptors;Organ Donor;Pain;pain patient;Pathway interactions;patient population;Peripheral Nerves;Price;Procedures;Productivity;Progress Reports;Quality Control;Recording of previous events;Recovery;Reporting;Research;Research Personnel;Research Project Grants;Resource Sharing;Site;Spinal Cord;Structure;Supervision;Synapses;therapeutic development;Tissue Banks;tissue processing;Tissue Procurements;tissue resource;Tissues;transcriptome;transcriptomics;University of Texas M D Anderson Cancer Center;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Aging;Clinical Research;Eye Disease and Disorders of Vision;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

PHR: Modified Public Health Relevance Section  Glaucoma, a leading cause of blindness worldwide and frequent cause of visual impairment in the US, is an important public health issue, affecting particular individuals at an earlier age and more commonly resulting in blindness. By exploring the tissue-specific genetic and physiologic basis of these differences, our research will provide support for our hypothesis proposing differences in oxygen/mitochondrial metabolism and oxidative stress (from “toxic” free radicals) within the tissues (trabecular meshwork) of the drain of the eye that controls eye pressure, the most significant modifiable risk factor for glaucoma. Improving our understanding of how certain individuals are more susceptible to damage will also expand potential novel pathways of therapy and prevention for all individuals afflicted by or at risk for this blinding disease.

PI_NAMEs: SIEGFRIED, CARLA J (contact)

PROGRAM_OFFICER_NAME: SONG, HONGMAN

PROJECT_TERMS: 8-hydroxy-2'-deoxyguanosine;Acceleration;Affect;African American;African ancestry;Age;Aggressive course;anterior chamber;antioxidant enzyme;Antioxidants;aqueous;Aqueous Humor;B-Lymphocytes;Bioenergetics;Biological;black patient;Black Populations;Black race;Blindness;Blood;catalase;Cell Culture Techniques;cell injury;Cells;Classification;Complex;Cornea;Data;Development;differential expression;Disease;disease disparity;Disease Progression;Disparity;Drug Metabolic Detoxication;early onset;Elements;Exposure to;Eye;Eye Banks;Foundations;Free Radicals;Functional disorder;Gene Expression;Gene Expression Profile;Genes;Genetic;Genotype;Glaucoma;Glutathione;Goals;Goniotomies;Haplogroup;High Prevalence;Homeostasis;Human;human study;improved;In Situ Hybridization;Individual;innovation;insight;interest;Knowledge;Link;Measurement;Measures;Metabolism;Metformin;Mitochondria;Mitochondrial DNA;mitochondrial metabolism;modifiable risk;Monkeys;neuroprotection;Niacinamide;novel;novel therapeutics;nuclear factor-erythroid 2;Open-Angle Glaucoma;Operative Surgical Procedures;Organelles;Oxidation-Reduction;oxidative damage;oxidative DNA damage;Oxidative Stress;Oxidative Stress Induction;Oxygen;Oxygen Consumption;Partial Pressure;Pathogenesis;Pathway interactions;Patient Self-Report;Patients;personalized therapeutic;Persons;Physiologic Intraocular Pressure;Physiological;Population Study;precision medicine;Predisposition;pressure;prevent;Prevention;Primary Open Angle Glaucoma;Production;protein expression;Protons;Public Health;Publishing;Race;racial difference;racial disparity;Reactive Oxygen Species;Reporting;Research;Risk;Risk Factors;RNA;Severities;Specimen;Stratification;Stress;Superoxide Dismutase;superoxide dismutase 1;System;Testing;Therapeutic;Thick;Tissues;Trabecular meshwork structure;transcriptome sequencing;ubiquinol;Vision research;Visual impairment;Western Blotting;Work

PROJECT_TITLE: Understanding glaucoma risk and assessment of precision therapies: A study of mitochondria and oxidative stress in human trabecular meshwork

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]


NIH_SPENDING_CATS: Chronic Pain;Genetics;Human Genome;Neurosciences;Pain Research

PROJECT_TERMS: Address;Adult;Age;ATAC-seq;Atlases;Awareness;Biological;Brain;Cell Nucleus;cell type;Cells;chronic pain;chronic pain patient;chronic painful condition;Code;Coupled;Data;Data Set;Development;Diabetic Neuralgia;Dorsal;dorsal horn;epitranscriptome;epitranscriptomics;ethnic diversity;Event;experimental study;Generations;Genes;Genetic Transcription;Genome;Horns;Human;Individual;insight;Knowledge;life span;Link;Macrophage;Maps;Measures;men;Messenger RNA;Methods;Modification;Molecular;Molecular Profiling;Morphology;Mus;nanopore;Nervous System;Neurobiology;Neuroglia;Neurons;Nociception;Nociceptors;Nucleotides;Operative Surgical Procedures;Organ Donor;Pain;pain patient;pain signal;Paper;Pathology;Pathway interactions;Peripheral Nervous System;Phenotype;Play;Population Heterogeneity;Posterior Horn Cells;Regulatory Element;Reporting;Research Project Grants;Resolution;Resources;ribosome profiling;RNA;RNA Splicing;Rodent;Role;Sample Size;Sampling;Sensory;sex;single nucleus RNA-sequencing;species difference;Spinal;Spinal Cord;Spinal Ganglia;Spinothalamic Tracts;Split-Pool Ligation Transcriptome sequencing;Synapses;T-Lymphocyte;TACR1 gene;Techniques;Technology;therapeutic target;Tissues;Transcript;transcriptome;transcriptomics;Translational Regulation;Translations;translatome;Untranslated Regions;Woman;Work

PROJECT_TITLE: Mapping the human DRG and spinal cord functional genome at cellular and spatial resolution


PI_NAMEs: BORSHEIM, ELISABET  (contact)

PROJECT_TERMS: Adolescent;Adult;American;Area;Arkansas;base;Bioenergetics;Biological;Biomedical Research;career;Cell Energetics;Cells;Cellular Metabolic Process;Child;Clinical Chemistry;Core Facility;Data Analyses;data dissemination;design;Development;Doctor of Philosophy;Education;Energy Metabolism;Exercise Physiology;Extramural Activities;Fatty acid glycerol esters;fatty liver disease;Fee-for-Service Plans;Fluorescence;Funding;Goals;Grant;Heart Diseases;Human;human model;Hypertension;in vivo;Incidence;Institution;instrumentation;Insulin Resistance;investigator training;Knowledge;Laboratories;Leadership;life span;Mass Spectrum Analysis;Mediating;Mentors;Mentorship;Metabolic;Metabolic dysfunction;Metabolism;Methodology;Mission;Mitochondria;Monitor;Non-Insulin-Dependent Diabetes Mellitus;novel;novel strategies;Obesity;obesity in children;obesity prevention;Organelles;oxidation;Phase;Pilot Projects;Play;Population;Pre-Clinical Model;preclinical study;prevent;Prevention Research;Prevention strategy;Prevention therapy;programs;protein degradation;real time monitoring;recruit;Research;Research Assistant;Research Design;Research Institute;Research Personnel;Research Project Grants;Research Support;Resolution;Respiratory physiology;Role;Sampling;Services;skills;Spirometry;stable isotope;Techniques;Technology;theories;Tissues;Training;Translational Research;Water

PROJECT_TITLE: Center for Childhood Obesity Prevention - Metabolism and Bioenergetics Core


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Genetics;Lung;Pediatric

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative The fetal immune system is considered underdeveloped, immature, and involved in maintaining immune tolerance. However, macrophages produced in the liver and trafficking to multiple fetal tissues have a pro- inflammatory phenotype. In the lung, this inflammatory signature peaks around birth and then becomes suppressed in mature alveolar macrophages in the postnatal period. This proposal will characterize the development of inflammatory macrophage phenotypes in fetal tissues and test specific molecular mechanisms regulating expression of these inflammatory signatures.

PI_NAMEs: PRINCE, LAWRENCE S (contact)

PROGRAM_OFFICER_NAME: MAJJI, SAI PRASANNA

PROJECT_TERMS: Adopted;Adult;Agonist;Alveolar Macrophages;Anti-Inflammatory Agents;Antigens;Binding;Birth;Brain;cell injury;Cell surface;Cells;Circulation;Complex;Computer Analysis;Computer Models;Cues;cytokine;Data;Data Set;deep learning model;Development;developmental immunology;Disease;diverse data;Enhancers;Epithelium;experimental study;fetal;fetal blood;Fetal Development;Fetal Liver;Fetal Lung;Fetal Tissues;Fetus;fighting;Gene Expression;Gene Expression Profile;Genes;Granulocyte-Macrophage Colony-Stimulating Factor;Human;Immune;Immune system;Immune Tolerance;Immunity;Immunology;Infant;Infection;Inflammation;Inflammatory;Injury;Innate Immune Response;Investigation;Knockout Mice;Kupffer Cells;Labor Onset;Liver;Lung;Machine Learning;Macrophage;Maps;Measures;Microbe;model development;Modeling;Molecular;Mothers;multidisciplinary;Multiomic Data;multiple omics;Mus;Myelogenous;Natural Immunity;Neonatal;Neonatal lung;Newborn Infant;NF-kappa B;novel;Nuclear Receptors;Organ;Organism;pathogen;Pathogenesis;pathogenic microbe;Pathway interactions;Pattern;Phenotype;Population;postnatal;postnatal period;Pregnancy;promoter;Property;Proteomics;Research Personnel;Resolution;response;Role;Signal Transduction;single cell analysis;System;Testing;Time;Tissues;trafficking;Travel;Yolk Sac

PROJECT_TITLE: Mechanisms Regulating Inflammatory Phenotypes in Fetal Macrophages

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-EMS-E(55)R]


ADMINISTERING_IC: AR

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Aging;Arthritis;Chronic Pain;Osteoarthritis;Osteoporosis;Pain Research;Physical Injury - Accidents and Adverse Effects

ORG_CITY: ITHACA

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: CORNELL UNIVERSITY

PHR: Osteoarthritis (OA) is the leading cause of disability in adults, affecting 1 out of 5 adults, and is associated with traumatic joint injury in 10% of cases. The proposed experiments will test whether intermittent parathyroid hormone, an FDA-approved treatment that increases bone formation, can restore joint health in post-traumatic OA by promoting cartilage regeneration, reducing pain and modulating subchondral bone mass.

PI_NAMEs: VAN DER MEULEN, MARJOLEIN C (contact)

PROGRAM_OFFICER_NAME: PINTUCCI, GIUSEPPE

PROJECT_TERMS: Adult;Affect;Anabolism;arthropathies;articular cartilage;Attenuated;Biological Process;bone;bone loss;bone mass;Bone remodeling;Bone Resorption;Bone Spur;Bone Tissue;Cartilage;cartilage regeneration;Cells;Chondrogenesis;clinical practice;cortical bone;Data;Degenerative polyarthritis;Development;Developmental Process;disability;Disease;Disease Progression;Dose;Event;experimental study;FDA approved;Female;Gene Expression;Gene Expression Profiling;Genes;Health;immune function;Immune response;immunoregulation;improved;In Situ Hybridization;in vivo;Individual;Inflammation;Injury;joint function;joint injury;joint loading;joint stiffness;Joints;Knee;Knee joint;Ligaments;loss of function;male;Meniscus structure of joint;Modeling;Morphology;Mus;nerve supply;Neuroimmune;Neuroimmunomodulation;Osteogenesis;Osteoporosis;Outcome;Pain;pain reduction;Paired Comparison;Pathology;Pharmaceutical Preparations;Population;Pre-Clinical Model;Predisposition;preservation;prevent;Property;PTH gene;response;Role;Sclerosis;single-cell RNA sequencing;subchondral bone;Swelling;Synovial Membrane;Testing;Thick;Tissue-Specific Gene Expression;Tissues;transmission process;Traumatic Arthropathy

PROJECT_TITLE: Modulating PTOA development with parathyroid hormone

STUDY_SECTION: SBSR

STUDY_SECTION_NAME: Skeletal Biology Structure and Regeneration Study Section[SBSR]


NIH_SPENDING_CATS: Back Pain;Chronic Pain;Clinical Research;Genetics;Human Genome;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy

PI_NAMEs: CURATOLO, MICHELE  (contact)

PROJECT_TERMS: Automobile Driving;Axon;cancer pain;Cell Nucleus;Cell Proliferation;cell type;Cells;Characteristics;Chest;Chronic low back pain;chronic pain patient;chronic painful condition;Clinical;clinical phenotype;Data;Data Set;Development;disability;Facet joint structure;Fascia;Foundations;Future;Generations;Genetic Transcription;Goals;Health Expenditures;Human;In Vitro;Individual;Infiltration;insight;Intervertebral disc structure;Investigation;Joints;Knowledge;Ligands;Maps;Mediator;Messenger RNA;Modeling;Molecular;molecular pathology;Molecular Profiling;Muscle;Nerve;neural;Neurons;Neuropathy;Neurosciences;Nociception;Nociceptors;Operative Surgical Procedures;opioid epidemic;Organ Donor;Outcome;Pain;Pain Disorder;Pain Free;painful neuropathy;Pathologic;Pathway interactions;Patients;Peripheral;pharmacologic;Pharmacology;Pharmacology Study;Phenotype;phenotypic data;receptor;recruit;Research Project Grants;Resolution;Role;Sampling;Sensory;Signal Transduction;single nucleus RNA-sequencing;single-cell RNA sequencing;Spinal Cord;Spinal Ganglia;Spine surgery;Techniques;Testing;Therapeutic;therapeutic target;Tissue Sample;Tissues;transcriptome;transcriptome sequencing;transcriptomics;Validation;Work

PROJECT_TITLE: Mechanistic underpinnings of chronic low back pain