ORG_CITY: SANTA CRUZ

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA SANTA CRUZ

PHR: Project Narrative Over 6 million people die each year as a result of sepsis. We show that mice lacking the long noncoding RNA, GAPLINC are resistant to LPS induced septic shock. GAPLINC is conserved in humans and mice and here we will determine how GAPLINC contributes to the body’s responses during gram negative induced sepsis.

PI_NAMEs: CARPENTER, SUSAN  (contact)

PROGRAM_OFFICER_NAME: MINNICOZZI, MICHAEL

PROJECT_TERMS: Anti-sense RNA;ATAC-seq;Bacteremia;Bacteria;Binding;Biological Models;Bone Marrow;Cause of Death;Cells;Chemicals;Chimera organism;Chromatin;Clinical;Clinical Treatment;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;CRISPR/Cas technology;Cytosol;Data;design;drug development;Endotoxic Shock;Escherichia coli;Future;Gastric Adenocarcinoma;gene conservation;Gene Expression;Gene Expression Regulation;Genes;Genetic;Genetic Transcription;Genome;Hospitals;Human;Human Genome;Immune;Immune response;in vivo;Infection;Infiltration;Inflammation;insight;knock-down;Knock-out;Knockout Mice;Length;Macrophage;malignant stomach neoplasm;Mediating;Molecular;monocyte;mouse model;Mus;Natural Immunity;neutrophil;new therapeutic target;Nucleotides;overexpression;Pathway interactions;Patients;Persons;Phenotype;Play;progenitor;Proteins;Regulation;Resistance;response;RNA;RNA Binding;Role;Sepsis;Septic Shock;Shock;Small Interfering RNA;Testing;Therapeutic;Therapeutic Intervention;Transcript;transcriptome sequencing;Transgenes;Transgenic Animals;Untranslated RNA

PROJECT_TITLE: Determining the conserved molecular mechanisms contributing to inflammation during Sepsis

STUDY_SECTION: III

STUDY_SECTION_NAME: Innate Immunity and Inflammation Study Section[III]


ADMINISTERING_IC: CA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Clinical Research;Homelessness;Pediatric;Social Determinants of Health

ORG_CITY: PITTSBURGH

ORG_COUNTRY: UNITED STATES

ORG_DEPT: MISCELLANEOUS

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: NARRATIVE The Hillman Academy at the University of Pittsburgh Medical Center will train 24 underrepresented minority and disadvantaged youth per year from Pittsburgh and surrounding areas by providing authentic cancer research experiences, didactic training from a tailored curriculum, and professional and academic development to prepare them for careers in cancer research and care. The Academy will also impact our local communities through outreach events facilitated by our long-standing community partners. The Hillman Academy will build from the strengths of our institution and past successes in working with emerging scientists from underserved backgrounds to broaden participation and expand diversity in the cancer workforce, which will produce more effective research and help decrease health disparities in cancer.

PI_NAMEs: BAKKENIST, CHRISTOPHER J.;BOONE, DAVID  (contact)

PROGRAM_OFFICER_NAME: GHOSH, SANGEETA AHUJA

PROJECT_TERMS: Academic support;Academy;Address;Advanced Malignant Neoplasm;anti-cancer research;Area;Award;Awareness;broadening participation research;Cancer Biology;cancer care;Cancer Center;cancer education;cancer health disparity;Cancer Research Project;career;Collaborations;college;Communities;community organizations;community partners;Complement;Development;Disadvantaged;disadvantaged background;disadvantaged student;Discipline;economic disparity;Education;Educational Curriculum;Educational process of instructing;Educational workshop;Equity;Event;experience;Faculty;Funding;Healthcare;high school;High School Student;Homeless Youth;improved;Infrastructure;Institution;Internships;Lead;Leadership;Learning Module;literacy;Malignant Neoplasms;Manuscripts;matriculation;Medical center;member;Mentors;Minority;Minority Groups;multimodality;novel;outreach;Participant;peer coaching;Positioning Attribute;programs;Readiness;recruit;Reduce health disparities;Research;Research Project Grants;Research Training;Role;Running;Scholarship;Schools;Science;Science, Technology, Engineering and Mathematics Education;Scientist;Site;skills;STEM career;student participation;Students;success;symposium;System;Training;Training Programs;Translating;undergraduate student;Underrepresented Minority;underrepresented minority student;Universities;volunteer;Work;Youth

PROJECT_TITLE: The UPMC Hillman Cancer Center Academy


ADMINISTERING_IC: AI

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Contraception/Reproduction;Emerging Infectious Diseases;Immunization;Infectious Diseases;Pediatric;Pregnancy;Rare Diseases;Vector-Borne Diseases;Women's Health Research;Zika Virus

ORG_CITY: ATLANTA

ORG_DEPT: PEDIATRICS

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: ZIKV is a mosquito-borne flavivirus of significant public health concern that has recently emerged in the Americas and has been linked to severe neonatal birth defects, including microcephaly and spontaneous abortion, and Guillain-Barre syndrome in adults. Our proposal seeks to understand how gestational age influences mechanisms of antibody-mediated ZIKV infection of the human placenta. Our studies will likely reveal therapeutic targets and provide insights for development a vaccine to protect against ZIKV infection.

PI_NAMEs: SUTHAR, MEHUL SHAMAL (contact);WRAMMERT, JENS PETER

PROGRAM_OFFICER_NAME: GAUTAM, RAJEEV

PROJECT_TERMS: Address;Adult;Affinity;age effect;Americas;Antibodies;Antibody Response;Antibody Specificity;Antigen-Antibody Complex;Bathing;Binding;Biological Assay;Biological Models;Biology;Blood;Brazil;Cells;Chorionic villi;Congenital Abnormality;cross reactivity;Dengue;Dengue Virus;Environment;Epidemic;Fab Immunoglobulins;Fc domain;Fc Receptor;fetal;fetal blood;Flavivirus;Flavivirus Infections;Gases;Generations;Gestational Age;Goals;Guillain Barré Syndrome;Histologic;Homeostasis;Human;Humoral Immunities;IgG Receptors;IgG1;IgG2;IgG3;IgG4;Immune response;Immunoglobulin G;Immunologics;Infection;Inflammation;Inflammatory Response;insight;Integration Host Factors;Link;Macrophage;Mediating;Microcephaly;Modeling;Monoclonal Antibodies;mosquito-borne;Mothers;mRNA sequencing;Neonatal;neonatal Fc receptor;neutralizing antibody;Nutrient;Observational epidemiology;Outcome;Pathogenesis;Pathway interactions;Penetration;permissiveness;Placenta;placental infection;Placentation;Play;Pregnancy;Pregnant Women;Primary Infection;Public Health;receptor expression;Reporting;RNA;secondary infection;Serum;Specificity;Spontaneous abortion;Symptoms;Syncytiotrophoblast;System;therapeutic target;transcytosis;Transportation;Uterus;vaccine development;Vascular blood supply;Villous;Villus;Viral;Virion;Virus;wasting;ZIKA;Zika Virus;ZIKV exposure;ZIKV infection

PROJECT_TITLE: Understanding the mechanisms of antibody-mediated transcytosis of ZIKV within the placenta

STUDY_SECTION: PN

STUDY_SECTION_NAME: Pregnancy and Neonatology Study Section[PN]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Colorectal Cancer;Digestive Diseases;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Microbiome;Nutrition;Obesity;Physical Activity;Prevention

ORG_CITY: BOSTON

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

ORG_STATE: MA

PHR: PROJECT NARRATIVE Colorectal adenoma is the precursor for the vast majority of colorectal cancers, the second leading cause of cancer death in the U.S. Gut microbes are pivotal in integrating colorectal cancer-associated lifestyle factors, including Western diet, obesity, physical activity, and aspirin use, with host physiology and metabolism; in turn disturbances in the gut microbiota have been linked to colorectal adenoma and cancer. Understanding the intricate relationship between lifestyle factors, the gut microbiota, and colorectal neoplasia will illuminate significant insights into the etiopathogenesis of colorectal cancer and launch novel research into cancer prevention through gut microbiota-targeted diagnostics and therapeutics.

PI_NAMEs: SONG, MINGYANG  (contact)

PROGRAM_OFFICER_NAME: SIMONDS, NAOKO ISHIBE

PROJECT_TERMS: Address;adenoma;African American population;aged;Aspirin;Bacteria;Bile Acids;Biochemical;Biological Sciences;Butyrates;Cancer Etiology;cancer prevention;carcinogenesis;carcinogenicity;Carcinoma;Cell Physiology;Cessation of life;Chronic;Chronic Disease;cohort;Cohort Studies;Collection;Colonoscopy;Colorectal;Colorectal Adenoma;Colorectal Cancer;colorectal cancer prevention;colorectal cancer risk;Colorectal Neoplasms;Colorectal Polyp;Communities;cost efficient;Cues;Deoxycholic Acid;Development;Diagnosis;Diagnostic;Diet;Enrollment;Enterobacteriaceae;Environmental Risk Factor;Etiology;Eubacterium;Exposure to;Feces;Firmicutes;follow-up;functional genomics;Funding;Fusobacterium;Gene Expression;Genes;genomic profiles;gut microbes;gut microbiome;gut microbiota;high risk;Human;human data;Immune;immunoregulation;Incidence;Inflammatory;insight;intestinal tumorigenesis;Investigation;Life Style;lifestyle factors;Link;Lithocholic Acid;low socioeconomic status;Malignant Neoplasms;Massachusetts;men;Metabolic;Metabolism;metabolome;Microbe;microbial;microbial community;microbial composition;microbiota;Mucous Membrane;multidisciplinary;neoplastic;novel;Nurses;Nurses' Health Study;Obesity;Oncogenic;Participant;Pathway interactions;Pattern;permissiveness;Pharmaceutical Preparations;Physical activity;Physiology;Play;Polypectomy;Polyps;Population Heterogeneity;prospective;Prospective cohort;Prospective Studies;recruit;Reproducibility of Results;Research;Research Personnel;Risk;Risk Factors;risk sharing;Role;socioeconomic disadvantage;stool sample;Taxonomy;Testing;Therapeutic;Tissues;tumor;Tumor-infiltrating immune cells;tumorigenesis;tumorigenic;Unhealthy Diet;Update;Volatile Fatty Acids;western diet;White Women;Woman;Women's cohort

PROJECT_TITLE: The Gut Microbiome, Lifestyle, and Colorectal Neoplasia

STUDY_SECTION: CHSB

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology B Study Section[CHSB]


NIH_SPENDING_CATS: Cancer;Climate-Related Exposures and Conditions;Dental, Oral, and Craniofacial Disease;Infectious Diseases;Microbiome;Prevention;Rare Diseases;Sexually Transmitted Infections;Skin Cancer

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative: This proposal is founded on an innovative idea that normal human virome can play a beneficial role against cancer development in epithelial cells. The overarching aim of this proposal is to determine the underlying mechanism that governs the interplay of commensal papillomaviruses, epithelial tumors and the immune system. The outcomes of this research will create the path to the application of commensal virome for cancer therapy, which will benefit a large number of individuals in the United States and around the world.

PI_NAMEs: DEMEHRI, SHADMEHR  (contact);JOH, JOONGHO

PROGRAM_OFFICER_NAME: RASOOLY, AVRAHAM

PROJECT_TERMS: Address;Adult;Aerodigestive Tract;Aging;Antigen Presentation;Antigens;antiviral immunity;Architecture;cancer cell;cancer prevention;cancer therapy;Cancerous;carcinogenesis;carcinogenicity;Carcinogens;Carcinoma;CD8-Positive T-Lymphocytes;cell injury;Cells;chemokine;Clinical Research;Clonal Expansion;commensal bacteria;Complement;cytokine;Development;Elderly;Environmental Carcinogens;Epithelial Cells;Epithelium;Exposure to;Foundations;Goals;Head and Neck Cancer;head and neck cancer patient;Health;high risk;Homeostasis;Human;Human Papillomavirus;human virome;Hyperplasia;Immune;Immune response;Immune signaling;Immune system;Immunity;Immunocompetent;Immunologic Factors;improved;Individual;innate immune pathways;innovation;Lesion;Low risk HPV;Maintenance;Malignant - descriptor;Malignant Neoplasms;Mediating;microbiome;Modeling;Molecular;mouse model;mucosal site;Mucous Membrane;Mus;Mutate;Mutation;Nature;normal microbiota;Normal tissue morphology;novel;novel strategies;Oral mucous membrane structure;Outcome;Outcomes Research;Papillomavirus;Patients;Pattern;Persons;Play;premalignant;prevent;Process;Proliferating;protective effect;reproductive tract;Research;Risk;Role;Skin;Skin Cancer;Skin Carcinogenesis;Skin colonization;T cell response;T-Cell Activation;T-Cell Depletion;T-Lymphocyte;Testing;Tissues;transcriptome sequencing;Treatment Cost;tumor;ultraviolet;Ultraviolet Rays;United States;UV carcinogenesis;UV induced;Vaccination;Viral;Viral Antigens;virome;Virus;Work

PROJECT_TITLE: Immunity to commensal papillomaviruses for cancer therapy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-M(08)F]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Heart Disease;Kidney Disease

ORG_CITY: SEATTLE

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: NARRATIVE Acute decompensated heart failure is a major cause of hospitalization and poor clinical outcomes in the U.S. population. Kidney function is a key determinant of management and prognosis in patients with acute decompensated heart failure, but current clinical measures of kidney function are inadequate for use in these patients. The goal of this proposal to identify novel kidney measures that may be used to guide therapy and determine prognosis in patients with acute decompensated heart failure.

PI_NAMEs: BANSAL, NISHA  (contact)

PROGRAM_OFFICER_NAME: SCHULMAN, IVONNE HERNANDEZ

PROJECT_TERMS: Acute;acute care;Address;Admission activity;Affect;Algorithms;Angiotensinogen;Body Weight Changes;Cardiac;Clinical;clinical prognosis;Clinical Trials;Complex;Congestive Heart Failure;Creatinine;Critical Illness;Data;Echocardiography;EFRAC;Endothelium;Event;evidence base;FABP1 gene;Foundations;Functional disorder;Future;Glomerular Filtration Rate;Goals;Guidelines;Health Status;Heart failure;hemodynamics;high risk;Hospitalization;Hospitals;IL18 gene;improved;improved outcome;Inflammation;Injury;injury and repair;Injury to Kidney;insulin-like growth factor binding protein-related protein 1;Investigation;ischemic injury;Kidney;kidney repair;Knowledge;LCN2 gene;Length of Stay;Leukocyte L1 Antigen Complex;Literature;Measurement;Measures;Mechanics;novel;Outcome;Oxidative Stress;Patient Admission;Patients;Population;preservation;Prognosis;prognostic;Prospective Studies;Public Health;public health priorities;recruit;Recurrence;Renal function;Reporting;response;Risk;Role;Sentinel;Serum;Severities;Standardization;Stress;Symptoms;Testing;Titrations;Treatment Failure;Treatment Protocols;treatment strategy;Tubular formation;Universities;Washington;Withdrawal;Work

PROJECT_TITLE: Kidney Injury in Patients with Acute Decompensated Heart Failure


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Clinical Research;Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Neurosciences;Orphan Drug;Precision Medicine;Prevention;Rare Diseases

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: Narrative We propose a multi-scale framework for treatment allocation, treatment follow-up and treatment monitoring to provide precision medicine for brain tumor patients. We will develop algorithms integrating clinical, molecular and imaging data for therapeutic purposes. We will focus on the development of multi-scale biomarkers that are predictive of treatment response, suggest the use of novel drugs and help during treatment monitoring.

PI_NAMEs: GEVAERT, OLIVIER  (contact)

PROGRAM_OFFICER_NAME: KIM, BOKLYE

PROJECT_TERMS: Adult;Algorithms;Area;Basic Science;Biological Assay;Biological Markers;Brain Neoplasms;Cancer Patient;cancer site;Clinical;clinical application;clinical care;clinical practice;clinical trial recruitment;Clinical Trials;cohort;Computer Models;Computing Methodologies;Data;data framework;data fusion;Data Set;Data Sources;Development;Diagnosis;Diagnostic;Diagnostic Imaging;digital pathology;DNA Methylation;DNA Repair Enzymes;Drug Targeting;Epidermal Growth Factor Receptor;epigenetic silencing;Evaluation;Event;Eye;follow-up;Gene Expression;Gene Expression Profile;genome sequencing;genomic profiling;Glioma;High-Throughput Nucleotide Sequencing;Human;Image;imaging biomarker;imaging modality;in vivo;Informatics;Link;Machine Learning;Magnetic Resonance Imaging;Malignant Neoplasms;Medical center;methylation pattern;MGMT gene;Modality;Modeling;Molecular;Molecular Profiling;Monitor;multi-scale modeling;multimodal modeling;multimodality;multiple omics;multiscale data;mutational status;neuro-oncology;novel;novel strategies;novel therapeutics;Outcome;pathology imaging;Pathway interactions;patient biomarkers;Patient imaging;Patients;Pattern;Pharmaceutical Preparations;precision medicine;predict clinical outcome;Prediction of Response to Therapy;predictive marker;Prognosis;Prognostic Marker;Property;prospective;prospective test;quantitative imaging;radiological imaging;radiologist;Research;Resistance;response;Role;Somatic Mutation;survival outcome;survival prediction;synergism;Technology;temozolomide;Therapeutic;Time;Translating;Translations;Treatment outcome;treatment response;treatment strategy;tumor;Tumor Subtype;Tumor Tissue;whole slide imaging;Work

PROJECT_TITLE: Multi-scale modeling of glioma for the prediction of treatment response, treatment monitoring and treatment allocation

STUDY_SECTION: BCHI

STUDY_SECTION_NAME: Biomedical Computing and Health Informatics Study Section[BCHI]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Genetics;Huntington's Disease;Neurodegenerative;Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PHR: This proposal seeks to identify novel methods raised by identifying RRM2B alternative isoform as a genetic modifier, which rests firmly on information obtained directly from human patients to treat Huntington’s disease, a fatal neurological disorder affecting the lives of more than 100,000 people in the U.S, and advance mechanistic understanding of this debilitating, poorly understood condition. In addition to bringing us closer to a cure for HD, its completion will shed light on the fundamental causes of similar neurological disorders and pioneer innovative therapeutic strategies for other related incurable diseases.

PI_NAMEs: SEONG, IHN SIK  (contact)

PROGRAM_OFFICER_NAME: MILLER, DANIEL L

PROJECT_TERMS: Affect;Age of Onset;Alleles;Amino Acids;Anti-sense RNA;Binding;Biochemical;Biological;biological adaptation to stress;Biological Assay;Biological Models;Biology;CAG repeat;Cell model;Cell Survival;Cells;Cellular Stress;Characteristics;Chemicals;Chromosomes;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;CRISPR/Cas technology;Data;design;Diphosphates;Disease;disease phenotype;DNA Maintenance;Drug Design;Engineering;exon skipping;Exons;expectation;experimental study;follow-up;Foundations;Future;Gene Expression;gene therapy;Gene Transfer;Genes;Genetic;genetic analysis;Genetic study;genome wide association study;Goals;Haplotypes;Homeostasis;Human;Huntington Disease;Huntington gene;induced pluripotent stem cell;Inherited;innovation;insight;Investigation;knock-down;Knock-out;Knockout Mice;Label;Length;Maintenance;Mediating;Methods;Mitochondria;Mitochondrial DNA;Mitochondrial DNA depletion syndromes;mitochondrial dysfunction;Modification;Molecular;motor symptom;Mutation;nerve stem cell;Nervous System Disorder;Neurodegenerative Disorders;neuron loss;Neuronal Differentiation;Neurons;new technology;novel;novel therapeutics;Onset of illness;Outcome;Oxidoreductase;Pathogenesis;Pathogenicity;Pathologic;Pathway interactions;Patients;Persons;Phenotype;Play;Ploidies;polyglutamine;premature;prevent;Primates;protein complex;Protein Isoforms;Proteins;Proteomics;recognins;Regulation;Resources;response;Rest;Ribonucleosides;Ribonucleotide Reductase;Role;RRM1 gene;Sample Size;Series;short hairpin RNA delivery;Signal Transduction;Source;spatiotemporal;stem cell differentiation;Stress;stressor;Techniques;Testing;Therapeutic;therapeutic candidate;therapeutic development;Therapeutic Effect;Therapeutic Intervention;Time;tool;TP53 gene;transcriptome;Trinucleotide Repeat Expansion;ubiquitin-protein ligase;Untranslated RNA;Variant;Work

PROJECT_TITLE: An Alternative Isoform of RRM2B as a Genetic Modifier in Huntington's Disease

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: NARRATIVE The collective findings from this project will provide a better understanding of the genetic architecture for Alzheimer disease (AD) in African Americans, permit us to develop new hypotheses about pathogenic mechanisms leading to AD, identify proteins as targets for development of drugs to treat AD, and provide genetic markers for use in AD risk assessment and profiling subjects for clinical trials.

PI_NAMEs: FARRER, LINDSAY A. (contact)

PROGRAM_OFFICER_NAME: BENNANI-BAITI, MICHAEL

PROJECT_TERMS: African American population;African ancestry;AKAP9 gene;Alzheimer's Disease;Alzheimer's disease risk;Amyloid beta-Protein;biobank;Bioinformatics;Biological Markers;Brain;brain tissue;Cell Line;Cells;cigarette smoking;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;Collection;Data;Data Set;Dementia;Diabetes Mellitus;differential expression;drug development;Drug Screening;Elasticity;endophenotype;Environment;Environmental Risk Factor;Enzyme-Linked Immunosorbent Assay;Ethnic Population;European ancestry;experimental study;Funding;Gene Expression;Genes;Genetic;genetic architecture;Genetic Diseases;Genetic Markers;Genetic study;Genetic Variation;genome wide association study;Genotype;Human;hypercholesterolemia;Hypertension;Immunofluorescence Immunologic;In Vitro;Incidence;Individual;Induced pluripotent stem cell derived human neuron;Induced pluripotent stem cell derived neurons;knock-down;Lead;Mediating;Mediator;Mendelian randomization;Modeling;Modification;Neurons;neurophysiology;next generation sequencing;non-genetic;novel;Obesity;Parents;Pathogenicity;Pathologic;Persons;phenome;Phenotype;pleiotropism;polygenic risk score;Population;Population Heterogeneity;positional cloning;Production;programs;Protein Overexpression;Proteins;Recommendation;Risk Assessment;Risk Factors;risk variant;Sample Size;Sampling;Series;Small Interfering RNA;small molecule;statistics;tau Proteins;Testing;trait;transcriptome sequencing;transgene expression;Underrepresented Minority;Validation;Variant;Veterans

PROJECT_TITLE: Alzheimer Disease Genetic Architecture in African Americans

STUDY_SECTION: NAME

STUDY_SECTION_NAME: Neurological, Aging and Musculoskeletal Epidemiology Study Section[NAME]


NIH_SPENDING_CATS: Brain Disorders;Neurodegenerative;Neurosciences;Pain Research;Rare Diseases

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative Having shown that calcium-activated chloride channels (CaCCs), which serve important physiological functions including modulation of neuronal signaling, are encoded by TMEM16A and TMEM16B of the TMEM16 family of “transmembrane proteins of unknown function,” we were surprised to find that TMEM16C assembles with the Slack sodium-activated potassium channel in dorsal root ganglion nociceptive neurons to modulate neuronal excitability and pain sensitivity, and TMEM16C function in the brain is important for homeostatic thermoregulation. It was also surprising to find that TMEM16F not only has the dual functions of calcium-activated cation channel and calcium-activated lipid scramblase but is also required for extracellular vesicle formation. This project aims to investigate the molecular and cell biological mechanisms underlying important functions of these TMEM16 family members in neuronal signaling, thermoregulation, and neurodegeneration.

PI_NAMEs: JAN, LILY Y (contact)

PROGRAM_OFFICER_NAME: UMANAH, GEORGE KWABENA ESSIEN

PROJECT_TERMS: Action Potentials;Anions;Biological;Blood Coagulation Disorders;Brain;Brain region;Calcium;Calcium Binding;Calcium Channel;Cations;cell type;Cells;Chloride Channels;Clustered Regularly Interspaced Short Palindromic Repeats;constriction;Cryoelectron Microscopy;extracellular vesicles;Family;Family member;Febrile Convulsions;human disease;Integral Membrane Protein;Investigation;Ion Channel;Ions;Knock-in;Knockout Mice;Learning;Lipids;Mediating;member;Molecular;Monitor;mouse model;Nerve Degeneration;Neurodegenerative Disorders;neuronal excitability;Neurons;neurotransmission;Nociceptors;pain sensitivity;Pathway interactions;Pattern;Physiologic Thermoregulation;Physiological;Potassium Channel;Proteins;Rest;Scott syndrome;Site-Directed Mutagenesis;Sodium;Spinal Ganglia;Spinocerebellar Ataxias;Structure;Visualization;Work

PROJECT_TITLE: The TMEM16 Family of Ion Channels and Lipid Scramblases


NIH_SPENDING_CATS: Brain Disorders;Genetics;Huntington's Disease;Neurodegenerative;Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: IRVINE

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: Huntington's disease (HD) is a devastating degenerative brain disease for which no disease-modifying treatments are available. The proposed research will broadly focus on understanding early mechanisms that contribute to pathogenesis in HD and develop therapeutic strategies. Broadly the goals of the grant will focus on protein quality control in the presence of mutant Huntingtin expression and how it impacts both DNA damage responses and cell type specific epigenomics and RNA biology in multiple systems.

PI_NAMEs: THOMPSON, LESLIE MICHELS (contact)

PROJECT_TERMS: Address;Age of Onset;Biology;Brain;Brain Diseases;CAG repeat;Cell Physiology;cell type;Cells;Cessation of life;Chronic;Clinical;Collaborations;Combined Modality Therapy;Cryo-electron tomography;Data;Disease;disease model;DNA Damage;Epigenetic Process;epigenomics;Event;Gene Expression;Genes;Genetic;Goals;Grant;Huntington Disease;Huntington gene;Impaired cognition;induced pluripotent stem cell;Inherited;Investigation;Knowledge;Learning;Mass Spectrum Analysis;Methods;Molecular;Motor;mouse model;mutant;Neurodegenerative Disorders;Neurons;Outcome Measure;Pathogenesis;Pathology;Pathway interactions;Patients;polyglutamine;Population;Post-Translational Protein Processing;premature;Process;Productivity;programs;Proteins;proteostasis;Quality Control;Research;Resources;response;RNA;single-cell RNA sequencing;System;Systems Biology;Technology;Therapeutic;therapy development

PROJECT_TITLE: Molecular Mechanisms of Pathogenesis in Huntington’s disease


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science;Biomedical Imaging;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Nutrition;Obesity;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: LINCOLN

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF NEBRASKA LINCOLN

ORG_STATE: NE

PHR: Project Narrative The public health relevance of the proposed research is in explicating modifiable factors that contribute to neural vulnerabilities for obesity within developmental and environmental context. By elucidating which factors during childhood and adolescence are most critical to emerging neural vulnerabilities in young adulthood, the proposed study will directly inform the targets and timing of interventions to prevent and treat obesity. Thus, the proposed research is relevant to NIDDK's strategic focus on understanding modifiable factors that contribute to obesity risk and informing interventions to promote healthy weight.

PI_NAMEs: NELSON, TIMOTHY DAVID (contact);SAVAGE, CARY R

PROGRAM_OFFICER_NAME: OSGANIAN, VOULA

PROJECT_TERMS: actigraphy;Address;Adolescence;Adult;Affective;Area;Attention;Behavior;Behavioral;behavioral construct;Brain;Childhood;Cognitive;cost;Data;Data Collection;Development;Diet;Dimensions;Environment;Environmental Impact;Environmental Risk Factor;Equilibrium;excessive weight gain;executive function;Face;Food;Foundations;Functional Magnetic Resonance Imaging;Funding;Future;Goals;Health;Health behavior;healthy weight;Hour;Hyperphagia;Individual;Individual Differences;innovation;insight;Intervention;Link;Literature;Longitudinal Studies;Magnetic Resonance Imaging;Measurement;Measures;Methods;Modeling;National Institute of Diabetes and Digestive and Kidney Diseases;negative affect;neural;neuroimaging;Neuropsychology;Neurosciences;Neurosciences Research;novel;Nursery Schools;Obesity;obesity development;obesity prevention;obesity risk;obesity treatment;obesogenic;Phase;Positioning Attribute;Predictive Factor;Prefrontal Cortex;prevent;Prevention program;Process;Public Health;public health relevance;Questionnaires;Regulation;Reporter;Research;Research Personnel;Rewards;Risk;Role;Sampling;Science;Sleep;Symptoms;System;Unhealthy Diet;United States;United States National Institutes of Health;virtual;Weight;young adult

PROJECT_TITLE: Modifiable predictors of neural vulnerabilities for obesity

STUDY_SECTION: CIDO

STUDY_SECTION_NAME: Clinical and Integrative Diabetes and Obesity Study Section[CIDO]


ADMINISTERING_IC: GM

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Genetics;Human Genome

ORG_CITY: LAS VEGAS

ORG_NAME: UNIVERSITY OF NEVADA LAS VEGAS

ORG_STATE: NV

PHR: Project Narrative It is important to understand how specific transcript or protein isoforms contribute to the differentiation of cells to understand human development and disease. But, currently technical challenges exist to infer that information from the single cell RNA-seq data that is sparse and noisy. This project proposes to develop a novel method to infer differential exon usage for specific cell- types from smart-seq based single cell RNA-seq, and validate the method with data generated from alternative protocols.

PI_NAMEs: HAN, MIRA  (contact)

PROGRAM_OFFICER_NAME: MATUKUMALLI, LAKSHMI KUMAR

PROJECT_TERMS: Algorithms;Alternative Splicing;Atlases;Benchmarking;Binomial Distribution;Cell Differentiation process;Cell Separation;cell type;Cells;Data;Data Set;Detection;Development;Disease;Dropout;Event;Exons;Foundations;Genes;Human;Human Development;human disease;improved;Individual;interest;Knowledge;Length;Literature;Maps;Methods;Modeling;Molecular;Negative Binomial Distributions;neglect;new technology;Noise;novel;novel strategies;organ growth;Peripheral Blood Mononuclear Cell;Probability;Protein Isoforms;Protocols documentation;Regulation;Resolution;RNA Splicing;Sensitivity and Specificity;simulation;single molecule;single-cell RNA sequencing;stem;Time;Tissues;Transcript;transcriptome;transcriptome sequencing;Variant;Work

PROJECT_TITLE: Differential exon usage in single cell RNA-seq


NIH_SPENDING_CATS: Breast Cancer;Cancer;Genetics;Women's Health Research

ORG_CITY: NEW YORK

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: PROJECT NARRATIVE Epithelial-to-Mesenchymal Transition (EMT) is a cancer cell plasticity program linked to metastasis. Based on our novel data this proposal will explore the hypothesis that EMT requires the generation of specific modified ribosomes that translate EMT-driven mRNAs that fuels metastasis. We propose that EMT-specific ribosomes are manufactured by (i) activation of ribosome genes by a Pol I-Snail transcriptional complex and (ii) Snail promotes binding of METTL5 on de novo synthesized rRNA enabling rRNA specific m6A modifications before its incorporation into the ribosome. By forming a complex with METTL3 Snail also directs m6A modifications of selective mRNA enabling recruitment of the non-canonical DAP5/eIF3d/METTL3 translation complex to drive selective m6A marked mRNA translation in the mesenchymal state.

PI_NAMEs: VINCENT, CLARA THERESA (contact)

PROGRAM_OFFICER_NAME: MERCER, NATALIA

PROJECT_TERMS: Aftercare;Animal Model;Applications Grants;Binding;Binding Sites;Biogenesis;Biopsy;Blood Vessels;Breast Cancer Cell;Breast Cancer cell line;breast cancer metastasis;cancer cell;cell motility;Cells;Chemoresistance;ChIP-seq;Clinical Treatment;Complex;Data;Development;Disease;Disease Progression;Distant;DNA Polymerase I;DNA Polymerase II;Drug Targeting;effective therapy;Epithelial Cells;epithelial to mesenchymal transition;Epithelium;G1 Phase;Gene Expression;Gene Expression Regulation;Generations;Genes;Genetic Transcription;genome-wide;Human;infectious disease treatment;Investigation;Knowledge;Link;Malignant Breast Neoplasm;manufacture;Mass Spectrum Analysis;Mediating;Mesenchymal;Messenger RNA;Metastatic breast cancer;methylome;Methyltransferase;Modification;Molecular;molecular marker;mRNA Translation;Mus;Neoplasm Metastasis;neoplastic cell;novel;novel therapeutics;Nuclear;Organ;overexpression;Paraffin Embedding;Patients;Peptide Initiation Factors;Physiological;Play;Positioning Attribute;power analysis;prevent;Primary Neoplasm;Process;programs;Property;recruit;Recurrence;Research;Ribosomal DNA;Ribosomal RNA;Ribosomes;RNA Polymerase I;Role;Signal Transduction;Snails;Stimulus;Therapeutic;therapeutic target;transcription factor;Transcriptional Regulation;Transforming Growth Factor beta;Translating;Translational Regulation;Translations;triple-negative invasive breast carcinoma;tumor;tumor progression;vector

PROJECT_TITLE: Translation regulation of the mesenchymal transition by the rRNA and mRNA m6A axis

STUDY_SECTION: CAMP

STUDY_SECTION_NAME: Cancer Molecular Pathobiology Study Section[CAMP]


NIH_SPENDING_CATS: Breast Cancer;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Digestive Diseases;Orphan Drug;Pancreatic Cancer;Rare Diseases;Women's Health Research

ORG_CITY: SAN JUAN

ORG_NAME: UNIVERSITY OF PUERTO RICO MED SCIENCES

ORG_STATE: PR

PHR: Pancreatic cancer presents with a dismal 3% five-year survival rate at stage IV metastatic disease, and the survival rates for breast cancer drops from 90% to 20% when the breast cancers establish distant metastases. Therefore, this proposal will characterize two new metastasis targeted therapeutics in preclinical mouse models and fresh breast and pancreatic cancer patient tissue. This study promises to shift paradigms and impact metastatic cancer cure.

PI_NAMEs: DHARMAWARDHANE, SURANGANIE  (contact)

PROGRAM_OFFICER_NAME: BASKIR, RUBIN SAM

PROJECT_TERMS: Address;Affect;Animal Model;Antibodies;Antineoplastic Agents;Authorship;Award;Biological;Biological Assay;Biological Availability;biomarker selection;Biopsy;Biotechnology;Body Weight;Breast Cancer Cell;Breast Cancer Model;Breast Cancer Patient;breast cancer progression;cancer cell;Cancer Etiology;cancer stem cell;cancer subtypes;Canis familiaris;Carcinoma;cell growth;Cell Line;Cell model;cell motility;Cell Proliferation;Cell Surface Receptors;Cells;Cessation of life;Colon;commercialization;comparative efficacy;Complex;Data;design;Development;Diagnostic;Disease;Disseminated Malignant Neoplasm;Distant Metastasis;Doctor of Philosophy;doctoral student;Drops;drug development;drug efficacy;Drug Kinetics;drug testing;effective therapy;Environment;Evaluation;Family;Goals;graduate student;Guanine Nucleotide Exchange Factors;Guanosine Triphosphate;Guanosine Triphosphate Phosphohydrolases;Image;Immune;immune cell infiltrate;Immunofluorescence Immunologic;Immunohistochemistry;In Situ;in vivo;inhibitor;Injections;innovation;Invaded;Lead;Legal patent;Luciferases;Malignant Breast Neoplasm;Malignant neoplasm of pancreas;Malignant Neoplasms;MDA MB 231;MDA-MB-468;medical schools;Medical Students;Mentors;metastasis prevention;Metastatic breast cancer;mortality;mouse model;Mus;Mutate;Neoplasm Metastasis;new therapeutic target;novel therapeutics;Oncogenic;Operative Surgical Procedures;Outcome;Outcome Study;overexpression;p21 activated kinase;pancreatic cancer cells;pancreatic cancer patients;pancreatic neoplasm;Parents;Patients;pharmacodynamic biomarker;Pharmacodynamics;phase I trial;Physiological;Plasma;pre-clinical;prevent;Productivity;Prognosis;programs;Publications;Puerto Rico;rac GTP-Binding Proteins;Rattus;Research;Research Design;Resistance;rho;Rodent;Safety;Signal Pathway;skill acquisition;stem;student training;Students;subcutaneous;Survival Rate;Tail;targeted treatment;Techniques;Testing;Therapeutic;therapy resistant;Tissues;Toxic effect;Training;triple-negative invasive breast carcinoma;tumor growth;tumor microenvironment;Tumor Tissue;Tumor-infiltrating immune cells;undergraduate student;Underrepresented Minority;Universities;Validation;Veins

PROJECT_TITLE: MBQ-167 derivatives as antimetastatic cancer agents.


ADMINISTERING_IC: AR

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: New York

ORG_NAME: HOSPITAL FOR SPECIAL SURGERY

PHR: The Combined Engineering and Orthopaedics Training Program educates, supports, and empowers exceptional pre-doctoral and post-doctoral trainees to excel in careers that apply the principles of engineering to maintain and restore musculoskeletal function. The emphasis is on developing well-rounded scientists and clinician-scientists who will leverage cross-disciplinary collaborations, cross-institutional resources, and comprehensive mentoring to develop successful independent careers in the orthopaedic sciences.

PI_NAMEs: MAHER, SUZANNE A. (contact);VAN DER MEULEN, MARJOLEIN C

PROGRAM_OFFICER_NAME: VINCENT, ISAAH S


ORG_CITY: BALTIMORE

ORG_DEPT: NEUROLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Narrative (Relevance) Understanding gut microbiota kidney cross-talk during AKI/recovery is important to improve patient outcomes. The proposed studies in mice and humans will results in the identification of microbial communities and metabolic components involved in this cross-talk to set the stage for novel therapeutics. Focus on renal immunology and short-chain fatty acids/receptors will reveal novel mechanisms by which gut microbiota modulate AKI and recovery.

PI_NAMEs: RABB, HAMID  (contact)

PROJECT_TERMS: Acute Renal Failure with Renal Papillary Necrosis;Adoptive Transfer;Affect;Anti-Inflammatory Agents;Antibiotics;Antibodies;Antiinflammatory Effect;Applications Grants;Bacteria;Binding;Blood;Bone Marrow Transplantation;Cardiac Surgery procedures;CD3 Antigens;CD8-Positive T-Lymphocytes;CD8B1 gene;Cells;Cisplatin;Clinic;Clinical;Communication;Creatinine;Data;Endothelium;endotoxin receptor;Endotoxins;Epithelium;Evaluation;experimental study;Feces;FFAR3 gene;Germ-Free;gut bacteria;gut microbiome;gut microbiota;hemodynamics;Human;human microbiota;Immune;immune activation;Immunologics;Immunology;Immunophenotyping;improved;Inflammation;Inflammatory;Injury;injury and repair;injury recovery;Injury to Kidney;Ischemia;Kidney;kidney cell;Kidney Diseases;Kidney Transplantation;Knockout Mice;Link;LoxP-flanked allele;Measures;Mediating;Metabolic;metabolomics;Metagenomics;microbial;microbial community;microbiome;microbiota;Modeling;Molecular;Morbidity - disease rate;mortality;murine colitis;Mus;novel;novel marker;novel therapeutics;olfactory receptor;Outcome;Pathway interactions;Patient-Focused Outcomes;Patients;Phase;Phenotype;Population;pregnant;Probiotics;Process;programmed cell death ligand 1;programmed cell death protein 1;Property;Publishing;receptor;Receptor Signaling;Recovery;Regulatory T-Lymphocyte;renal ischemia;repaired;Reperfusion Therapy;Research;response;Role;Serum;Signal Transduction;Smell Perception;Source;stool sample;T-Lymphocyte;Testing;Therapeutic Studies;Tissues;TLR4 gene;tool;Translating;Tubular formation;Volatile Fatty Acids;Wild Type Mouse;Work

PROJECT_TITLE: Acute kidney injury and microbiome

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Genetics

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE Spliceosomes are cellular machines responsible for nuclear RNA splicing in eukaryotic cells. This proposal will answer outstanding questions about spliceosome function and its role in regulating gene expression. Since changes in splicing are implicated in a large number of human genetic diseases, our work could lead to new insights into disease pathology and treatments.

PI_NAMEs: HOSKINS, AARON ANDREW (contact)

PROGRAM_OFFICER_NAME: CZAPLINSKI, KEVIN

PROJECT_TERMS: 3' Splice Site;Active Sites;Address;Alternative Splicing;ATP phosphohydrolase;Biochemical;Chemicals;Complex;Cryoelectron Microscopy;Disease;Eukaryotic Cell;Exons;Experimental Genetics;Fluorescence Microscopy;Gene Expression;Genetic Diseases;genetic information;genetic regulatory protein;Goals;Human;Human Genetics;inhibitor;insight;interdisciplinary approach;Introns;Knowledge;Label;Laboratory Research;Messenger RNA;Methods;Molecular Conformation;mRNA Precursor;Nuclear RNA;Pathology;Pathway interactions;preservation;Process;Proteins;Reaction;Regulation;RNA;RNA Splicing;Role;single molecule;Site;small molecule inhibitor;Small Nuclear Ribonucleoproteins;Spliceosome Assembly Pathway;Spliceosomes;Structure;Techniques;Transcript;U6 Small Nuclear Ribonucleoproteins;Vision;Work;Yeasts

PROJECT_TITLE: Mechanisms of Spliceosome Assembly and Regulation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-K(55)R]


NIH_SPENDING_CATS: Cancer;Clinical Research;Genetics;Hematology;Infectious Diseases;Lymphatic Research;Lymphoma;Microbiome;Rare Diseases;Skin Cancer

ORG_DEPT: PATHOLOGY

PHR: Project Narrative Cutaneous T-cell lymphoma is a poorly understood cancer of immune cells, characterized by accumulation of T lymphocytes (a type of immune cell) in the skin. We suspect that bacterial exposure leads to disease progression and aim to explore the role of skin-associated bacteria in this malignancy. In an effort to gain a better understanding of the pathogenesis of this enigmatic cancer, we propose to survey the type of bacteria associated with the skin of patients, examine the proteins produced by these bacteria and use our novel mouse model of this disease to interrogate precisely how bacterial clinical isolates promote cancer.

PI_NAMEs: KORALOV, SERGEI BORISOVICH (contact)

PROGRAM_OFFICER_NAME: HOWCROFT, THOMAS K

PROJECT_TERMS: Abscess;Address;advanced disease;Animal Model;Antibiotic Therapy;Bacteria;Bacterial Infections;Benign;biobank;Biopsy Specimen;Blood;Blood typing procedure;cancer cell;Cell Survival;cell transformation;Cells;Characteristics;chemokine;Chronic;Clinical;clinical center;Clonal Evolution;Coculture Techniques;commensal bacteria;Cutaneous T-cell lymphoma;cytokine;Data;Dermal;Development;Disease;disease model;Disease Progression;Endothelial Cells;Environment;epidemiology study;Epithelial Cells;Epithelium;Epitopes;Etiology;experimental study;Exposure to;Future;Gene Rearrangement;Genes;Genetic Predisposition to Disease;genetic risk factor;Genetic Transcription;Genetically Engineered Mouse;genome sequencing;Genus staphylococcus;Germ-Free;Gnotobiotic;High Prevalence;high throughput technology;House mice;Human;Immune;improved;In Vitro;in vivo;Individual;Inflammation;Inflammatory;insight;Link;lymphadenopathy;Lymphocyte;Malignant - descriptor;Malignant Neoplasms;Methods;Microbe;microbial;microbial products;Modeling;mouse model;multimodality;Mutation;neoplastic cell;Non-Hodgkin's Lymphoma;novel;Organism;pathobiont;Pathogenesis;pathogenic bacteria;Pathologic;Pathway interactions;Patients;permissiveness;Play;Population;Production;Proliferating;Proteins;Protocols documentation;Research;Resolution;Role;Severity of illness;single cell technology;single-cell RNA sequencing;Site;Skin;skin microbiota;Skin Plaques;Specimen;Standardization;Staphylococcus aureus;Superantigens;Surface;Surveys;T-Cell Activation;T-Cell Lymphoma;T-Cell Proliferation;T-Cell Receptor Genes;T-Cell Transformation;T-Lymphocyte;Therapeutic;Therapeutic Intervention;Time;Toxin;transcriptomics;Tropism;tumor;tumor microenvironment;Virulence Factors;Work

PROJECT_TITLE: Role of S.aureus in Cutaneous T Cell Lymphoma Pathogenesis

STUDY_SECTION: HIBP

STUDY_SECTION_NAME: Host Interactions with Bacterial Pathogens Study Section[HIBP]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Genetics;Human Genome;Pediatric

ORG_DEPT: DENTISTRY

PHR: PROJECT NARRATIVE Cleft lip with or without cleft palate (CL/P) represents the most common craniofacial birth defect and is a burden for the individual and society. We will investigate the cell behaviors, genetic pathways, and regulatory networks underlying facial prominence fusion to identify new genes for prenatal diagnostics and tissue repair of CL/P.

PI_NAMEs: SELLERI, LICIA  (contact)

PROGRAM_OFFICER_NAME: SAIFUDEEN, ZUBAIDA

PROJECT_TERMS: Apoptosis;Apoptotic;Bioinformatics;Biological Assay;Bromodeoxyuridine;cdc Genes;cell behavior;Cell Cycle;Cell Cycle Arrest;Cell Cycle Progression;Cell Cycle Regulation;Cell Proliferation;Cells;Cephalic;Cleavage Under Targets and Release Using Nuclease;Cleft lip with or without cleft palate;Cleft Palate;comparison control;Congenital Abnormality;craniofacial;Cryoultramicrotomy;Development;Diagnostic;Effector Cell;Embryo;Epithelial Cells;epithelial to mesenchymal transition;Epithelium;Exhibits;experimental study;Face;Fostering;Frontonasal Prominence;Genes;Genetic;Genetic Transcription;Grant;Histone H3;Human;Image;Immunofluorescence Immunologic;Impairment;In Situ Hybridization;in vivo;Individual;inhibitor;Lip structure;Live Birth;Maxillary Prominence;Mediating;Mesenchyme;Microdissection;Molecular;Molecular Profiling;Morphogenesis;mouse model;Mus;mutant;Neural Crest;orofacial cleft;palate repair;Pathogenesis;Pathway interactions;Population;Pregnancy;Premaxillary palate;prenatal;Process;progenitor;programs;Publishing;Quantitative Reverse Transcriptase PCR;repair strategy;Reporting;Research;single-cell RNA sequencing;Societies;spatiotemporal;Stains;Testing;Time;tissue repair;Tissues;Transcript;transcription factor;transcriptome;Work;wound healing

PROJECT_TITLE: Pbx-Directed Control of Cellular Behaviors that Drive Midface Morphogenesis

STUDY_SECTION: SBDD

STUDY_SECTION_NAME: Skeletal Biology Development and Disease Study Section[SBDD]


NIH_SPENDING_CATS: Autoimmune Disease;Bioengineering;Biotechnology;Diabetes;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Transplantation

ORG_CITY: WINSTON-SALEM

ORG_DEPT: SURGERY

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

ORG_STATE: NC

PHR: Re le v ance A major barrier in manufacturing insulin -producing islet-like clusters from stem cells is the inability to reproducibly and efficiently generate and sustain mature β cells in culture. Herein, we propose to engineer a physiomimetic pancreatic niche by combining a novel through-pore microwell perfusion plate and human pancreatic dECM produced using our detergent-free decellularization protocol. This platform will allow systematic evaluation of multiple biophysical and biochemical factors on the functional maturation and maintenance of islet-like clusters and will identify the optimal conditions for their reproducible biomanufacturing, which is critical for their application to therapeutic beta cell replacement in type-1 diabetes.

PI_NAMEs: ASTHANA, AMISH  (contact)

PROGRAM_OFFICER_NAME: ARREAZA-RUBIN, GUILLERMO

PROJECT_TERMS: 3-Dimensional;Adopted;Automation;Beta Cell;beta cell replacement;Biochemical;Biocompatible Materials;Biological Assay;Biology;Biomanufacturing;Biomedical Engineering;Biophysics;Bioreactors;C-Peptide;Cadaver;Calcium;Cell Culture Techniques;Cell Density;Cell Differentiation process;cell replacement therapy;Cell Transplantation;Cells;combinatorial;Complications of Diabetes Mellitus;Cues;Data;Detergents;Development;Diameter;effective therapy;Endocrine;Engineering;Environment;Evaluation;Excision;experimental study;Extracellular Matrix;Family suidae;Flow Cytometry;fluid flow;fluorescence microscope;Fura-2;Glucagon;Glucose;Head;Height;Human;human induced pluripotent stem cells;improved;Industrialization;innovation;Insulin;insulin secretion;Insulin-Dependent Diabetes Mellitus;islet;Islets of Langerhans;Islets of Langerhans Transplantation;Kinetics;Knowledge;Laboratories;live cell imaging;Maintenance;manufacture;Maturation-Promoting Factor;Measures;mechanical signal;Membrane;Metabolic Control;Minor;Molecular;Neonatal;novel;Nutrient;Organ Donor;Pancreas;Patients;Perfusion;Physiological;pluripotent stem cell differentiation;preservation;prevent;Prevention;Procedures;Process;progenitor;Protocols documentation;Quality of life;Reproducibility;Research;response;Source;stem cell differentiation;stem cells;Suspension Culture;System;Technology;Testing;Therapeutic;Time;tissue culture;Tissue Engineering;Transplantation;wasting

PROJECT_TITLE: A microwell perfusion plate for manufacturing and testing Islet-like clusters.


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biotechnology;Genetics;Neurosciences;Physical Injury - Accidents and Adverse Effects;Physical Rehabilitation;Rehabilitation;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_CITY: La Jolla

ORG_NAME: SALK INSTITUTE FOR BIOLOGICAL STUDIES

PHR: Sensory afferent feedback plays a critical role in controlling movement, however, we still know very little about the central transmission pathways and how they intersect with spinal motor system. Studies in this proposal will dissect the functional organization of the sensorimotor circuitry in the spinal cord, in order to better understand the control systems that regulate movement and to develop new approaches for treating spinal motor disorders and spinal cord injury, as well as neuropathic pain and chronic itch.

PI_NAMEs: GOULDING, MARTYN D (contact)

PROGRAM_OFFICER_NAME: DOPERALSKI, ADELE ELIZABETH

PROJECT_TERMS: Animals;Behavior;Behavioral Assay;cell type;Cells;chronic itch;Dorsal;Feedback;Forelimb;Genetic;genetic manipulation;Goals;grasp;Human;improved;insight;Interneurons;Light;Limb structure;Maps;Mechanics;Modeling;Motor;Motor Activity;motor behavior;motor control;motor disorder;mouse genetics;Movement;Neurons;novel strategies;optogenetics;painful neuropathy;Pathway interactions;Play;Population;Pruritus;Reflex action;Reporter;Role;Running;Sensory;sensory feedback;Spinal;Spinal Cord;Spinal cord injury;spinal reflex;Synapses;System;Touch sensation;transmission process;Walking;Withdrawal

PROJECT_TITLE: Spinal circuits for mechanical itch and light touch


NIH_SPENDING_CATS: Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_DEPT: UROLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative Health care delivery for patients with cancer has become increasingly centralized in regional referral centers over time. This proposal will examine the ways in which centralized cancer care may be both helping and harming patients, particularly those who may be less likely to receive care at regional referral centers (e.g., racial/ethnic minorities, low-income individuals, and rural residents). The results not only will provide new insight into how recent shifts in cancer delivery may have widened disparities in cancer outcomes, but also will provide strategies to improve outcomes for millions of cancer patients through improvements in the regional organization of cancer care.

PI_NAMEs: JACOBS, BRUCE L. (contact)

PROGRAM_OFFICER_NAME: GRIMES, GENEVIEVE M

PROJECT_TERMS: Address;Administrator;Area;biomedical referral center;Bladder;Brain;Breast;cancer care;Cancer Center;cancer health disparity;Cancer Patient;cancer therapy;care delivery;Caring;Characteristics;Clinical;Colorectal;Complex;Data;Data Set;design;Disparity;Esophagus;ethnic minority;experience;Goals;Guidelines;health care delivery;health disparity;hospital readmission;Hospitals;Human Resources;improved;improved outcome;Individual;Infrastructure;innovation;insight;Intervention;Interview;Left;Link;Liver;Low Income Population;Lung;Malignant Neoplasms;Measures;Mediating;Methods;Modeling;mortality;multidisciplinary;multiple datasets;neoplasm registry;New York;novel;Outcome;Pancreas;Patient Care;Patient-Focused Outcomes;Patients;Pennsylvania;Policies;Policy Maker;Population;Prostate;Provider;Quality of Care;Quality of life;racial minority;Resources;rural dwellers;sociodemographic disparity;sociodemographic group;Structure;Testing;Time;trend;United States;Work

PROJECT_TITLE: Centralization of Cancer Care: Implications for Access, Outcomes, and Disparities

STUDY_SECTION: HHD

STUDY_SECTION_NAME: Healthcare and Health Disparities Study Section[HHD]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Eating Disorders;Mental Health;Neurosciences;Nutrition;Obesity;Prevention

ORG_DEPT: NEUROSCIENCES

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Sights, smells and tastes associated with foods can be powerful drivers of food seeking behavior and consumption, even in the absence of hunger or physiologic need. We believe this phenomenon is a significant contributor to obesity, but the brain circuits and mechanisms underlying the phenomenon are poorly understood. This project uses cutting-edge neuroscience techniques to identify the neural circuits and mechanisms whereby sensory cues can drive consumption in the absence of hunger, and therefore, has the potential to identify new therapeutic targets for the treatment of obesity.

PI_NAMEs: RAMIREZ, ALEJANDRO  (contact)

PROGRAM_OFFICER_NAME: COOKE, BRAD

PROJECT_TERMS: Acute;Amygdaloid structure;Anatomy;Area;Association Learning;Attenuated;Automobile Driving;bariatric surgery;Behavior;Behavior Therapy;Behavioral Paradigm;Body Weight;Body Weight decreased;Brain;Brain imaging;Calcium;calcium indicator;Code;Consumption;craving;Cues;Diet;dieting;Eating;eating in absence of hunger;Elements;Environment;experimental study;Exposure to;feeding;Feeding behaviors;Food;food consumption;Foundations;Gene Expression;Goals;Histologic;Histology;Homeostasis;Human;Hunger;Hypothalamic structure;Image;Impairment;Ingestion;Lateral;Learning;Lesion;Mediating;Mus;Nerve;neural;neural circuit;Neuroanatomy;neuromechanism;Neurons;Neurosciences;new therapeutic target;novel therapeutics;Obesity;obesity development;obesity prevention;obesity treatment;optogenetics;Physiological;Population;Prevalence;Primates;Process;Property;Public Health;rapid weight gain;Rattus;Recombinants;Regulation;response;restoration;Rewards;Rodent Model;Satiation;Sensory;sensory stimulus;Signal Transduction;Smell Perception;sound;Structure;success;System;Taste Perception;Techniques;Testing;Time;tool;Training;Viral;Vision;Weight;Weight Gain

PROJECT_TITLE: Neural Mechanisms that Underlie Eating in the Absence of Hunger

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


ORG_NAME: EMORY UNIVERSITY

PHR: Antibody-Secreting Cells (ASC), including Plasma Cells, are the cells responsible for the production of protective antibodies in response to infections and vaccinations. However, rogue ASC that produce undesired antibodies against human tissues are also responsible for myriad antibody-mediated diseases including autoimmune diseases, allergy and transplant rejection. In this project, we will study the different types of ASC that provide protection and induce disease to understand their nature and regulatory programs. The information gained will improve our ability to design safer and more effective treatments multiple antibody-mediated diseases and modulatory strategies to optimize protective vaccine responses.

PI_NAMEs: SANZ, IGNACIO E. (contact)

PROGRAM_OFFICER_NAME: FERGUSON, STACY E

PROJECT_TERMS: Acute;Allergic Reaction;Animals;Antibodies;Antigens;Area;arm;Autoimmune Diseases;Autoimmune Responses;autoreactivity;B-Lymphocytes;base;Bioinformatics;Biological Response Modifier Therapy;Bone Marrow;Cell Aging;Cell Compartmentation;Cell Differentiation process;Cell Maturation;Cell Physiology;Cell Survival;Cells;Chromatin;Complementary DNA;Computer Analysis;COVID-19 pandemic;CRISPR/Cas technology;Data Set;data sharing;design;Development;Disease;DNA Methylation;effective therapy;Endowment;Ensure;Epigenetic Process;epigenetic regulation;epigenomics;EZH2 gene;Foundations;Generations;Genetic Transcription;Genome engineering;Goals;Graft Rejection;Health;Heme;Heterogeneity;histone modification;Human;human tissue;Hypersensitivity;immune function;Immune system;immunogenic;Immunoglobulin A;Immunoglobulin G;Immunoglobulin M;Immunoglobulin-Secreting Cells;improved;Infection;Information Dissemination;Institution;Investigation;Iron;Laboratory Personnel;Libraries;Longevity;Mediating;Memory;Memory B-Lymphocyte;Metabolic;Metabolism;methylation pattern;Molecular;Nature;overexpression;Pathogenicity;Pathway interactions;Plasma Cells;Plasmablast;Population;Preparation;Process;Production;programs;Regulation;Research Personnel;response;Role;Safety;Serology;SIRT1 gene;Systemic Lupus Erythematosus;Transcriptional Regulation;transcriptome;Vaccination;vaccine response;Work

PROJECT_TITLE: Plasma Cells in Health and Disease


PHR: Project Narrative: Per RFA do not complete in this project/core.

PROJECT_TERMS: Acute;Address;Antibodies;Antigens;Atlases;Autoantibodies;Autoimmune;Autoimmune Diseases;autoreactivity;B cell differentiation;B cell therapy;B-Lymphocytes;belimumab;Blood;Bone Marrow;CD19 gene;Cell Compartmentation;Cell Survival;Cells;Cellular biology;Clinical;Complement;Cues;Data;Data Set;design;Development;Disease;effective therapy;Endowment;Environment;Epigenetic Process;Generations;Genetic Transcription;Health;Heme;Heterogeneity;Human;human disease;Immune system;Immunoglobulin-Secreting Cells;Impairment;improved;In Vitro;in vivo evaluation;Inflammatory;insight;Kidney;Kinetics;Knowledge;Locales;Longevity;Lupus Nephritis;Maintenance;Mediating;Memory;Metabolic;Modeling;Molecular;Nature;neoplastic;Nephritis;Output;pathogenic autoantibodies;Pathogenicity;Pathway interactions;Patients;Phase;Phenotype;Physiological;Plasma Cells;Population;programs;Property;rational design;Reaction;Regulation;response;Rest;Role;Sampling;SARS-CoV-2 infection;single cell analysis;Source;standard of care;stem cells;Structure of germinal center of lymph node;synergism;Systemic Lupus Erythematosus;targeted agent;targeted treatment;Testing;Therapeutic;Tissues;Tonsil;tositumomab;Vaccination;vaccine response;Work

PROJECT_TITLE: Project 4


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Clinical Research

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Narrative Many studies have documented the presence of toxic chemicals in existing artificial turf fields and playgrounds. New materials are increasingly being used as alternatives in playing surfaces, but safety information is still lacking. Using a citizen science approach, we will characterize the chemicals in new materials and comprehensively evaluate the exposure of children to chemicals and heat under real-use conditions. The project campaign will communicate research findings among partnering organizations and communities at large.

PI_NAMEs: HARARI, HOMERO  (contact)

PROGRAM_OFFICER_NAME: O'FALLON, LIAM

PROJECT_TERMS: Address;Adult;Advocate;Air;Area;Biological Monitoring;carcinogenicity;Chemicals;Child;citizen science;Communication;Communities;community involvement;community organizations;community partners;Connecticut;Consultations;Decision Making;Education;Educational Materials;Environment;Environmental Health;Environmental Impact;experience;exposure route;Exposure to;Focus Groups;Future;Goals;Health;Ingestion;Injury;Interview;Knowledge;Laboratories;Life;Massachusetts;medical schools;member;Methods;neurotoxic;New Hampshire;New York;North America;Parents;Pattern;Pennsylvania;Plastics;Play;Poison;Policies;Policy Maker;Positioning Attribute;Process;Productivity;Recycling;Reporting;Research;Research Activity;Research Personnel;Research Project Grants;Rubber;Safety;Sampling;Schools;Scientist;Shoes;Silicon Dioxide;Skin;Smell Perception;Surface;Training;Uncertainty;wasting;Water;Woman

PROJECT_TITLE: Addressing Community Concerns and Assessing Exposures and Alternatives to Artificial Turf Fields and Playgrounds

STUDY_SECTION: CIHB

STUDY_SECTION_NAME: Community Influences on Health Behavior Study Section[CIHB]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE THIRD COAST CFAR OVERALL RESEARCH The Third Coast Center for AIDS Research has leveraged complementary strengths of Northwestern University, the University of Chicago, and partnering community organizations across Chicago to build a comprehensive infrastructure for multi-disciplinary, collaborative HIV research. As a result, research funding and interactions have grown in our first term. This unique and catalytic integration of disciplines and venues of HIV-related research expands in this renewal proposal, aiming to accelerate HIV elimination and improving health-span for persons living with HIV.

PI_NAMEs: D'AQUILA, RICHARD ;MUSTANSKI, BRIAN  (contact)

PROGRAM_OFFICER_NAME: REFSLAND, ERIC WILLIAM

PROJECT_TERMS: Acceleration;Acquired Immunodeficiency Syndrome;Adherence;African American;age acceleration;aging mechanism;aging related;aging related disease;AIDS prevention;Aquila;base;Behavioral;behavioral and social science;Behavioral Sciences;Biological Assay;Biological Markers;Blood;Caring;Cells;Chicago;Clinical;clinical phenotype;Clinical Sciences;cohort;Collaborations;Communities;community engagement;community organizations;community partners;comorbidity;Consultations;Data Analytics;Data Science;design;Development;Diagnostic;Discipline;Disease remission;Doctor of Philosophy;effective intervention;empowerment;Engineering;Epidemic;Foundations;Funding;Growth;Health;health data;Health Professional;healthspan;Heart;HIV;Illinois;Image;Immunity;implementation science;improved;Informatics;Infrastructure;innovation;Institution;interdisciplinary collaboration;Intervention;Magic;Market Research;men;Mentored Clinical Scientist Development Program;Mentors;Mission;Modeling;multidisciplinary;National Heart, Lung, and Blood Institute;Outcome;Partnership Practice;Persons;Populations at Risk;pre-exposure prophylaxis;Prevention;Probability;Productivity;programs;Public Health;recruit;Reporting;Research;Research Personnel;Resources;Risk;Science;Scientist;Sleep;social;Social Sciences;Solid;Specimen;Speed;Strategic Planning;success;synergism;Systems Biology;Technology;Testing;transgender women;translational pipeline;Translational Research;Universities;Viral;Viral Pathogenesis;Viremia;virology;Vulnerable Populations;Work;working group;young men who have sex with men

PROJECT_TITLE: Third Coast Center For AIDS Research


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Women's Health Research

ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: 6. Project Narrative The goals of this proposal are to determine the signaling cross-talk between the PI3K-AT and TBK1-TRAF2 pathways, and to evaluate the therapeutic efficacies of combined AKT and TBK1 inhibition in PDX and xenograft tumor models.

PI_NAMEs: HABELHAH, HASEM  (contact)

PROGRAM_OFFICER_NAME: GREENBERG, WILLIAM A

PROJECT_TERMS: Affect;AKT inhibition;anti-cancer research;Apoptosis;Bioinformatics;Biological Assay;Biological Models;biomarker identification;Breast Cancer Cell;Breast Cancer cell line;Breast Cancer therapy;cancer cell;Cancer cell line;Cancer Etiology;Cause of Death;Cell Line;Cell Physiology;Cell Survival;Cellular Stress;Cessation of life;Clinical Trials;Data;derepression;Development;Diagnosis;Disease;Drug resistance;Exhibits;Genes;glycogen synthase kinase 3 beta;Goals;Growth;Growth Factor;Harvest;Histopathology;Homologous Gene;In Vitro;in vivo;Induction of Apoptosis;inhibitor;kinase inhibitor;knock-down;Malignant Breast Neoplasm;Malignant Neoplasms;Maps;Mediating;Modeling;mortality;Mus;Neoplasm Metastasis;novel therapeutic intervention;overexpression;Pathway interactions;patient derived xenograft model;Patient-derived xenograft models of breast cancer;Peptides;Phosphorylation;Phosphorylation Site;Phosphotransferases;PIK3CG gene;Play;Pre-Clinical Model;predictive marker;Prognosis;Protein-Serine-Threonine Kinases;Proto-Oncogene Proteins c-akt;PTEN gene;recruit;Recurrent disease;Reporting;Resistance;Resistance development;response;RIPK1 gene;Role;Series;Serine;Signal Transduction;Small Interfering RNA;Solid Neoplasm;synergism;TBK1 gene;Testing;Therapeutic;TNF gene;tool;TRAF2 gene;Treatment Efficacy;treatment response;tumor;tumor growth;tumor xenograft;ubiquitin-protein ligase;Ubiquitination;Woman;Xenograft Model;Xenograft procedure

PROJECT_TITLE: The roles of TRAF2 and RIP1 in breast cancer cell survival

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 1 Study Section[MCT1]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Dissemination and Implementation Research;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Prevention;Substance Misuse

PHR: A Project Narrative is not required per the RFA.

PI_NAMEs: MUSTANSKI, BRIAN  (contact)

PROJECT_TERMS: Acceleration;Achievement;Acquired Immunodeficiency Syndrome;Administrative Supplement;AIDS prevention;Aquila;Award;base;Behavioral Sciences;Blood;career;Caring;Charge;Chicago;Cities;Clinical Sciences;Collaborations;Communication;Communities;community collaboration;community engagement;community partners;comorbidity;Consultations;Dedications;Development;Doctor of Philosophy;Education;effective intervention;eHealth;Ensure;Epidemic;Faculty;Federally Qualified Health Center;Feedback;Foundations;Funding;Goals;Growth;Health;HIV;Illinois;implementation science;improved;innovation;Institution;interdisciplinary collaboration;Investments;Journalism;knowledge translation;Leadership;Link;Magic;men;Mentors;mHealth;Modeling;multidisciplinary;Office of Administrative Management;Persons;Prevention;Probability;Process;Productivity;Progress Reports;Public Health;Research;research data dissemination;Research Personnel;Resource Sharing;Resources;response;Schools;service providers;Social Sciences;Strategic Planning;synergism;Time;tool;translational medicine;translational pipeline;Translational Research;United States National Institutes of Health;Universities;Viral Pathogenesis;Vision;Work;working group

PROJECT_TITLE: Administrative Core


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

ORG_CITY: CAMBRIDGE

ORG_DEPT: CHEMISTRY

ORG_NAME: HARVARD UNIVERSITY

PHR: Project Narrative  The design of small molecule drug candidates with well-defined three-dimensional properties has been directly correlated to their clinical success. This proposal describes a novel application of asymmetric ion pairing catalysis to the synthesis of compounds bearing carbon and silicon stereogenic centers that are largely inaccessible using existing methods. As the construction of complex small molecules is a limiting factor in drug discovery, the proposed research will assist scientists in the development of molecular tools and therapeutics to understand and treat human health.

PI_NAMEs: SHEVICK, SOPHIA LOUISE (contact)

PROGRAM_OFFICER_NAME: STAMM, JOYCE CHIN-CHIN NG

PROJECT_TITLE: Anion Abstraction From Hypervalent Silanes: Enantioselective Synthesis of Compounds Bearing Carbon and Silicon Stereogenic Centers


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Drug Abuse (NIDA only);HIV/AIDS;Health Services;Infectious Diseases;Pediatric;Pediatric - AIDS;Prevention;Substance Misuse

PI_NAMEs: TRINITAPOLI, JENNY A (contact)

PROJECT_TERMS: Abbreviations;Acquired Immunodeficiency Syndrome;Address;Administrative Supplement;Aging;Aquila;Automobile Driving;Award;Cardiovascular Diseases;care systems;career;career development;Chicago;Collaborations;Communities;community engaged research;community partners;comorbidity;Data;Development;Doctor of Philosophy;Epidemic;Event;experience;externship;Faculty;faculty support;Foundations;Funding;Funding Mechanisms;Future;Glossary;Goals;Grant;Growth;HIV;improved;Inequity;innovation;Institution;Investments;Leadership;Learning;member;Mentored Clinical Scientist Development Program;Mentors;Mentorship;Mississippi;National Heart, Lung, and Blood Institute;Partnership Practice;Pilot Projects;prevention service;Process;Program Development;programs;Research;Research Personnel;Research Priority;Research Project Grants;Resources;response;Rotation;Services;Sleep Disorders;Strategic Planning;Study Section;success;synergism;United States Health Resources and Services Administration;United States National Institutes of Health;United States Public Health Service;Universities;Work;working group

PROJECT_TITLE: Developmental Core


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Networking and Information Technology R&D (NITRD);Prevention;Substance Misuse

PI_NAMEs: RIDGWAY, JESSICA  (contact)

PROJECT_TERMS: Abbreviations;Acquired Immunodeficiency Syndrome;Address;adjudication;age acceleration;Aging;aging related;AIDS prevention;antiretroviral therapy;Area;behavioral and social science;Behavioral Sciences;Biological;Biostatistics Core;Cardiovascular Diseases;care providers;career development;Caring;Chicago;Cities;Clinic;Clinical;Clinical assessments;Clinical Data;clinical decision support;Clinical Informatics;Clinical Investigator;clinical phenotype;clinical practice;Clinical Research;Clinical Sciences;Collaborations;Colorectal;Communities;community engagement;community organizations;comorbidity;Computational Technique;computing resources;Conduct Clinical Trials;cytokine;Data;data warehouse;Development;Diagnosis;digital tool;Discipline;Disease;Educational Curriculum;eHealth;Electronic Health Record;Electronics;Eligibility Determination;Endothelium;Epidemic;Functional disorder;Funding;Future;Genitalia;Glossary;Goals;Growth;Health;Health system;HIV;HIV Infections;Human Subject Research;implementation science;improved;indexing;Inflammation;Infrastructure;innovation;Institution;Institutional Review Boards;Laboratories;Lesbian Gay Bisexual Transgender Queer;Link;Machine Learning;member;Mentored Clinical Scientist Development Program;Mentors;microbiome;Mission;Monitor;Mucous Membrane;National Heart, Lung, and Blood Institute;Older Population;operation;Outcome;Participant;Patient Outcomes Assessments;Patients;Persons;Population;Populations at Risk;pre-exposure prophylaxis;Predictive Analytics;Process;Program Development;programs;Provider;Public Health;reactive hyperemia;recruit;Reporting;repository;Research;Research Personnel;research study;Research Support;Resource Informatics;Resources;Risk;Scientist;screening program;service providers;Services;Site;Sleep Disorders;Social Sciences;Special Population;Specimen;Study Section;success;Technology;Tissue Procurements;Tonsil;tool;Translational Research;Treatment Effectiveness;United States National Institutes of Health;Universities;Update;Viral;Viral Pathogenesis;Vulnerable Populations

PROJECT_TITLE: Clinical Sciences Core


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Dissemination and Implementation Research;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Pediatric;Pediatric - AIDS;Prevention;Substance Misuse

PI_NAMEs: NEWCOMB, MICHAEL E (contact)

PROJECT_TERMS: Abbreviations;Acquired Immunodeficiency Syndrome;Address;Adult;Affect;age acceleration;aging related disease;AIDS prevention;Behavioral;behavioral and social science;Behavioral Research;Behavioral Sciences;Biometry;Caring;Chicago;Clinical;clinical development;Collaborations;Communities;community engaged research;community engagement;Community Participation;community partners;comorbidity;Computers;Consultations;Continuity of Patient Care;Data;Data Analyses;Data Analytics;data resource;Data Science Core;Data Sources;design;Development;Devices;diagnostic development;Discipline;Doctor of Philosophy;Educational workshop;effective intervention;effectiveness/implementation study;Enrollment;Epidemic;epidemiologic data;evidence base;Faculty;Funding;Geographic Information Systems;Glossary;Goals;Health;Health Sciences;Heterosexuals;high risk;HIV;HIV Seropositivity;Illinois;implementation research;implementation science;improved;Infrastructure;Injecting drug user;innovation;Institution;Interdisciplinary Study;interest;Intervention;Laboratories;Lead;Market Research;Medical;member;men who have sex with men;Modeling;Monitor;Movement;multidimensional data;novel;Outcome;Outcome Measure;outreach;Participant;Patients;Persons;Pharmaceutical Preparations;Population;pre-exposure prophylaxis;preclinical development;Prevention;Probability Samples;Public Health;Qualitative Research;Registries;Reporting;Research;Research Design;Research Methodology;Research Personnel;Research Training;Resources;Role;Sampling;scale up;Scientist;Services;Site;social;Social Sciences;success;systems research;Testing;Training;transgender women;uptake;Viral;women of color;young men who have sex with men;Youth

PROJECT_TITLE: Behavioral Social and Implementation Science Core


ADMINISTERING_IC: HL

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Mental Health;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: UNIVERSITY PARK

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

PHR: PROJECT NARRATIVE We propose to examine the magnitude of change in parents’ and children’s risk for cardiovascular disease (CVD) from before the COVID-19 pandemic to 18-24 months after pandemic onset (“post-pandemic time point”), and from the post-pandemic time point to a follow-up period 18 months later. The proposed project is uniquely positioned to examine important theoretical and practical public health questions, including: To what extent did the COVID-19 pandemic increase CVD risk among a sample of parents and their children?; which of the multiple stressors associated with this crisis (e.g., financial, mental health, social isolation, and family conflict) are most highly linked to increases in CVD risk in this sample?; and can universal prevention programming enhance parent and child resilience and mitigate crisis-related increases in CVD risk? This research will also inform future efforts to minimize the negative collateral health impacts of infectious disease epidemics – as well as other social, economic, and climate related crises – and will help program developers more precisely target salient mechanisms as well as families at highest risk.

PI_NAMEs: FEINBERG, MARK ETHAN;GRAHAM-ENGELAND, JENNIFER ELISE (contact)

PROGRAM_OFFICER_NAME: DONZE, LAURIE FRIEDMAN

PROJECT_TERMS: Acute;Anxiety;Blood Pressure;Body mass index;Cardiovascular Diseases;cardiovascular disorder risk;Child;Child Mental Health;Cholesterol;Climate;climate change;Communicable Diseases;Conflict (Psychology);coping;Couples;COVID-19;COVID-19 pandemic;COVID-19 pandemic effects;Data;Data Collection;Data Set;Development;Disasters;Disease;Dislocations;Distal;Economics;Education;Epidemic;Face;Family;family building;Family member;Financial Hardship;follow-up;Foundations;Frequencies;Funding;Future;Gender;Gene Expression;Glycosylated hemoglobin A;Health;high risk;Hostility;improved;Income;Inflammatory;inflammatory marker;Interleukin-6;Intervention;intervention effect;Investigation;Knowledge;Link;Loneliness;lonely individuals;Mediating;Mental Depression;Mental Health;Meta-Analysis;Myocardial Ischemia;Natural Disasters;pandemic disease;pandemic impact;pandemic stressor;Parents;Pathway interactions;Patient Self-Report;Peripheral;Personal Satisfaction;Phase;physical conditioning;Physiological;Positioning Attribute;post-pandemic;pre-pandemic;Prevention;Prevention program;preventive intervention;Process;programs;promote resilience;protective factors;Public Health;Randomized;randomized trial;Recovery;Research;resilience;Risk;Risk Factors;Risk Marker;Role;Sampling;social;Social Distance;Social isolation;Societies;Socioeconomic Status;Stress;stressor;stroke risk;Surveys;Time;universal prevention;Work

PROJECT_TITLE: The effects of pandemic-related stressors on change in CVD Risk: The protective role of universal prevention

STUDY_SECTION: SPIP

STUDY_SECTION_NAME: Social Psychology, Personality and Interpersonal Processes Study Section[SPIP]


NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: SEATTLE

ORG_NAME: INSTITUTE FOR SYSTEMS BIOLOGY

PHR: Project Narrative The NLRP3 inflammasome is an important mediator of inflammation in a variety of metabolic and infectious diseases but the mechanisms of its activation remain unresolved. Mitochondrial association is an important feature of NLRP3 activation but how these bioenergetic organelles regulate NLRP3 activation is an intricate puzzle. This proposal will thoroughly dissect the role of mitochondrial structures and their associated proteins in NLRP3 inflammasome activation and identify how this key organelle controls NLRP3 crosstalk with the RNA virus-sensing RLR signalling pathway, thereby yielding critical mechanistic insights into how mitochondria regulate not only inflammasome activity but also other innate sensing pathways converging on the mitochondria.

PI_NAMEs: SUBRAMANIAN, NAEHA  (contact)

PROGRAM_OFFICER_NAME: SINGLETON, KENTNER L

PROJECT_TERMS: Adaptor Signaling Protein;Autoimmune Diseases;autoinflammatory diseases;Bioenergetics;Biological Assay;CASP1 gene;Cells;Chemicals;Communicable Diseases;Complex;cytokine;Data;Detection;Fluorescence;Fluorescence Microscopy;Functional disorder;Generations;Goals;IL18 gene;Infection;Inflammasome;Inflammation Mediators;insight;Interferon-beta;Interferons;Interleukin-1 beta;Investigation;IRF3 gene;Knock-out;Link;Location;Mass Spectrum Analysis;Mediating;Membrane;Metabolic Diseases;Metabolic dysfunction;Mitochondria;Mitochondrial Proteins;Modeling;mouse model;Mus;mutant;N-terminal;Nigericin;Organelles;Outer Mitochondrial Membrane;Pathway interactions;peroxisome;Phase;Physiological;Play;Production;Proteins;receptor;Receptor Signaling;recruit;Resolution;response;RNA;RNA Virus Infections;RNA Viruses;Role;Sendai virus;sensor;Signal Pathway;Signal Transduction;Site;Solid;Stimulus;Structure;Toxin;Urate;viral detection;viral RNA;Virus Diseases;Visualization;X-Ray Tomography

PROJECT_TITLE: NLRP3 inflammasome activation and its crosstalk with RLR signaling at the mitochondria

STUDY_SECTION_NAME: Innate Immunity and Inflammation Study Section[III]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Prevention;Substance Misuse

PI_NAMEs: HOPE, THOMAS  (contact)

PROJECT_TERMS: Abbreviations;Acquired Immunodeficiency Syndrome;Address;Adherence;Administrative Supplement;Aging;aging related;aging related disease;AIDS prevention;Animal Model;Antibodies;Behavioral;Behavioral Sciences;Biological;Biological Assay;Biological Markers;Biology of Aging;biosafety level 2 facility;Cell Culture Techniques;Cells;Chicago;Chronic Disease;Clinical;Clinical Sciences;Collaborations;Colon;comorbidity;Complex;computing resources;Consultations;Continuity of Patient Care;Creativeness;Data;data acquisition;Data Set;design;Development;Discipline;Disease;Doctor of Philosophy;Engineering;Enzyme-Linked Immunosorbent Assay;Epidemic;epigenomics;Equipment;experience;Experimental Designs;experimental study;Faculty;Genes;Genetic;genome resource;Glossary;HIV;Human;Image;Imaging technology;Immunologics;Immunologist;Immunology;Immunology procedure;improved;in vivo;Infection;innovation;insight;Institution;instrumentation;interdisciplinary approach;Interdisciplinary Study;interest;Intervention;Journals;Knowledge;Laboratories;Laboratory Scientists;Macaca;meetings;member;Mentorship;metabolomics;Methods;Mission;Molecular;Molecular Biology;Monitor;multidisciplinary;multiple omics;new technology;Pathogenicity;Performance;Persons;Population;pre-exposure prophylaxis;prevent;programs;Proteomics;Reagent;Research;Research Personnel;Resources;Risk;Scientist;Services;single cell technology;SIV;social;Structure;Systems Biology;Technology;Tissue Procurements;Tissues;Tonsil;tool;Training;translational scientist;transmission process;United States National Institutes of Health;Universities;Viral Pathogenesis;virology;Virus;Work

PROJECT_TITLE: Viral Pathogenesis Core


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Dissemination and Implementation Research;Drug Abuse (NIDA only);HIV/AIDS;Health Services;Infectious Diseases;Prevention;Substance Misuse

PI_NAMEs: PHILLIPS, GREGORY L. (contact)

PROJECT_TERMS: Abbreviations;Acceleration;Acquired Immunodeficiency Syndrome;Address;Administrative Supplement;African American population;age group;Age Years;AIDS prevention;antiretroviral therapy;Award;Behavioral Sciences;black men who have sex with men;Caring;Chicago;Collaborations;Communities;community academic partnership;community based service;community organizations;community partners;Community Services;Consultations;cooking;Country;County;Data Sources;Development;Diagnosis;Doctor of Philosophy;Ensure;Epidemic;Ethnic Origin;Evaluation Research;Focus Groups;Foundations;Funding;Funding Mechanisms;Funding Opportunities;Glossary;Goals;Group Processes;Health;Health Services Accessibility;HIV;HIV diagnosis;HIV Infections;HIV/STD;Illinois;implementation research;implementation science;improved;Information Dissemination;innovation;interest;Leadership;Learning;member;men who have sex with men;Methods;Modeling;Not Hispanic or Latino;Partnership Practice;Persons;Population;pre-exposure prophylaxis;prevent;Prevention;Process;Productivity;Public Health;public health priorities;Race;Reporting;Research;Research Personnel;Resources;response;service delivery;service providers;Services;Social Sciences;success;Trust;United States Health Resources and Services Administration;United States National Institutes of Health;Universities;Viral;Work;working group

PROJECT_TITLE: Scientific Working Group


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Neurosciences;Pediatric

ORG_NAME: HUGO W. MOSER RES INST KENNEDY KRIEGER

PHR: Movement abilities affect a child’s physical, social and emotional well-being, as well as their educational success—all of which can last a lifetime. We will use home-based video games and in-person tests to develop a detailed timeline of when different movement learning mechanisms mature and how this process is affected by damage to the brain. This will provide the comprehensive understanding required to generate tailored therapeutic training strategies targeted to age, developmental maturity, gender and disease state.

PI_NAMEs: BASTIAN, AMY J. (contact)

PROGRAM_OFFICER_NAME: CHEN, DAOFEN

PROJECT_TITLE: Development of Mechanisms Underlying Human Motor Learning


ED_INST_TYPE: SCHOOLS OF EDUCATION

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Women's Health Research

ORG_CITY: EAST LANSING

ORG_NAME: MICHIGAN STATE UNIVERSITY

ORG_STATE: MI

PHR: Project Narrative This research program will provide key insights into the types of contextual supports and psychological mechanisms that are needed to encourage persistence in biomedical science careers, especially for women, underrepresented minorities, and first-generation college students, across three unique university contexts. An understanding of how and why contextual supports are effective for promoting entry into biomedical careers will aid in the design of effective experiences and help decision-makers better allocate resources toward evidence-based strategies to recruit and retain women, minorities, and first-generation college students into STEM fields. By following participants throughout college and for more than 5 years after college graduation, this research will provide key insights into factors supporting sustained persistence in the biomedical careers.

PI_NAMEs: LINNENBRINK-GARCIA, LISA  (contact)

PROGRAM_OFFICER_NAME: NELSON, SHAKIRA M

PROJECT_TITLE: Contextual Factors and Psychological Mechanisms that Support or Disrupt Biomedical Career Pathways

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hematology;Human Genome;Machine Learning and Artificial Intelligence;Microbiome;Networking and Information Technology R&D (NITRD);Patient Safety;Precision Medicine;Racial and Ethnic Minority Health Research

ORG_CITY: TUCSON

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: PROJECT NARRATIVE  This research project will help define new factors that contribute to variability in therapeutic warfarin dose requirements. The proposed research is relevant to public health because it has the potential to improve genotype-guided warfarin dosing algorithms and reduce adverse drug events associated with warfarin therapy. Thus, the proposed research is relevant to the part of the NIH mission that pertains to reducing the burden of adverse drug reactions in cardiovascular disease.

PI_NAMEs: KARNES, JASON HANSEN (contact)

PROGRAM_OFFICER_NAME: WARREN, RONALD Q

PROJECT_TERMS: 16S ribosomal RNA sequencing;Accounting;Address;Admixture;Adverse drug event;adverse drug reaction;Adverse event;Affect;African;African American population;Algorithms;Anticoagulants;Anticoagulation;bacterial community;bacterial genome sequencing;Cardiovascular Diseases;Characteristics;Clinic Visits;Clinical;Clinical Research;cohort;Collection;CYP2C9 gene;Data;Data Set;Development;Diet Records;dietary control;disparity reduction;diverse data;DNA;Dose;Drug Prescriptions;Drug Receptors;Emergency Situation;Enrollment;Enzymes;Epigenetic Process;Escherichia coli;European;European ancestry;Failure;Genes;Genetic;genome-wide;Genotype;Guidelines;gut bacteria;gut microbiome;Hospitalization;Hour;improved;Individual;International;Investigation;Latino;Latino Population;Linear Regressions;Machine Learning;machine learning model;Measures;Medical Research;medically underserved;microbial community;microbiome;Mission;Modeling;multi-racial;Native Americans;novel;Oral;Outcome;Patient Self-Report;Patients;Pattern;personalized predictions;Pharmaceutical Preparations;Pharmacogenetics;Pharmacogenomics;Population;Population Heterogeneity;Public Health;Race;Randomized, Controlled Trials;Research;Research Project Grants;response;Role;Safety;sample collection;Source;stool sample;support vector machine;Techniques;Testing;Therapeutic;training data;treatment disparity;United States;United States National Institutes of Health;Variant;Vitamin K;Warfarin;Work

PROJECT_TITLE: Leveraging the Microbiome, Local Admixture, and Machine Learning to Optimize Anticoagulant Pharmacogenomics in Medically Underserved Patients

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-A(04)]


ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: NARRATIVE  Heart attacks and strokes remain the leading cause of death in the United States and despite current guidelines on aggressive cholesterol treatment and blood pressure management, some people continue to suffer cardiovascular problems leading to a poor quality of life and high cost of health care. The proposed study will investigate the effects of inflammation on bleeding inside of plaques, called intraplaque hemorrhage, one of the important plaque risk features that can cause heart attacks and strokes. The study will help us to better understand the problem with intraplaque hemorrhage and discover potential new treatments that can further reduce heart attacks and strokes.

PI_NAMEs: KANTER, JENNY E.;KIM, FRANCIS  (contact);YUAN, CHUN

PROGRAM_OFFICER_NAME: SCHOPFER, DAVID WESLEY

PROJECT_TERMS: 3-Dimensional;Acceleration;Achievement;Address;Affect;Antibodies;Arterial Fatty Streak;atheroprotective;Atherosclerosis;B-Lymphocytes;blood pressure control;Blood Vessels;cardiovascular disorder risk;Cardiovascular system;Carotid Artery Plaques;Carotid Endarterectomy;Cause of Death;Cell Separation;Cells;Cholesterol;Clinical;Coculture Techniques;Collaborations;contrast enhanced;coronary plaque;Data;density;Development;driving force;Elements;Endothelial Cells;Endothelium;Erythrocytes;Event;Excision;follow-up;Follow-Up Studies;Goals;Growth;Guidelines;Health Care Costs;Hemoglobin;Hemorrhage;Histologic;histological studies;Histology;Human;Hypoxia;Image;Imaging Techniques;Immunoglobulin M;In Vitro;in vivo;Inflammation;Inflammatory;inhibitor therapy;Investigation;Ischemia;Knowledge;Lipids;Low-Density Lipoproteins;Macrophage;Magnetic Resonance Imaging;Measures;Myocardial Infarction;Necrosis;neovascularization;neovasculature;novel;novel therapeutic intervention;Oxygen;Pathogenesis;Pathology;Patients;Permeability;Persons;Plasma;prevent;Production;Quality of life;Residual state;response;Risk;Role;Scanning;Source;Specimen;Stroke;Testing;therapeutic target;Tissues;treatment response;Tunica Adventitia;United States;vasa vasorum;Vascular Diseases;Vascular Permeabilities

PROJECT_TITLE: Role of inflammation in intraplaque hemorrhage pathogenesis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-VH-D(02)M]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Lung;Pediatric;Prevention;Rare Diseases;Tuberculosis

ORG_CITY: NEW ORLEANS

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: NARRATIVE An estimated 205,000 children die of TB-related causes each year, the vast majority of whom do not receive treatment due to missed opportunities to diagnose and successfully treat, as current tests do not sensitively detect all forms of pediatric TB disease. We have reported that our novel serum-based TB assay (developed with the support of our previous R01 funding) can detect all forms of pediatric TB with high sensitivity and specificity, and now propose to extend our assay approach to generate a multiplex assay that can also identify individuals progressing from latent TB to active TB disease, as well as rapidly evaluate a patient’s response to TB therapy to determine treatment efficacy. To do so, we will continue identifying new biomarkers secreted by TB bacilli that identify each stage of TB in a well-established non-human primate model of HIV and TB, and determine the best biomarker combinations and thresholds to distinguish these stages their response to anti-TB treatment, and subsequently evaluate the performance of a multiplex assay develop from these parameters in multi-center cohorts of young children with or without HIV, latent TB infection or active TB.

PI_NAMEs: LYON, CHRISTOPHER J (contact)

PROGRAM_OFFICER_NAME: MAJJI, SAI PRASANNA

PROJECT_TERMS: accurate diagnosis;Address;Adult;Antigens;Antitubercular Agents;Bacillus;Bacteriology;Biological Assay;Biological Markers;biomarker identification;biomarker panel;Blood;Breast Feeding;Bronchoalveolar Lavage Fluid;CD8-Positive T-Lymphocytes;Child;Childhood;Clinical;co-infection;cohort;Cohort Studies;Collaborations;Data;Detection;Development;Devices;Diagnosis;Diagnostic;diagnostic assay;Diagnostic Procedure;Diagnostic Sensitivity;Disease;disease model;Disease Progression;drug-sensitive;Early Diagnosis;Enrollment;Evaluation;Exhibits;Exposure to;Funding;Goals;Guidelines;high risk;HIV;HIV diagnosis;HIV Infections;HIV/TB;Human;Immune;immune reconstitution;Immune response;improved;Individual;Infant;Infection;Inflammatory;latent infection;Life;Lung;Macrophage;Mass Spectrum Analysis;Measurement;Methods;Modeling;Monitor;mortality risk;Mucosal Immune Responses;multiplex assay;multiplex detection;mycobacterial;Mycobacterium tuberculosis;nonhuman primate;novel;pathogen;Pathology;patient response;Patients;Pediatric cohort;Peptides;Performance;Persons;phenotypic biomarker;Population;portability;Prediction of Response to Therapy;predictive modeling;Proteomics;Radiology Specialty;Reaction;Reporting;Resistance;respiratory;response;Sampling;Sensitivity and Specificity;Serum;SIV;Sputum;success;Symptoms;Syndrome;T-Lymphocyte Subsets;Testing;Time;Tissues;Translations;Treatment Efficacy;Treatment Failure;treatment response;Tuberculosis;Tuberculosis diagnosis;tuberculosis diagnostics;tuberculosis treatment;Validation;Variant;Viral Antigens;Viral Load result;Virulence Factors

PROJECT_TITLE: Mtb and HIV/SIV antigen peptide signatures as blood biomarkers to detect early infection to active disease in young children and NHP

STUDY_SECTION: HCAC

STUDY_SECTION_NAME: HIV Coinfections and HIV Associated Cancers Study Section[HCAC]


NIH_SPENDING_CATS: Aging;Bioengineering;Biotechnology;Gene Therapy;Genetics;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human;Transplantation

ORG_CITY: Aurora

ORG_DEPT: DERMATOLOGY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative We have developed a clinically relevant rejuvenating RNA cocktail that upon transfection elongates telomeres, improves the growth and functionality of cultured human adult cells. Using this rejuvenating cocktail, we propose to develop new cellular technologies that would (1) improve the expansion of human primary somatic cells by promoting their rejuvenation and (2) allow for precise gene editing directly in primary cell lines followed by a clonal expansion of these genetically modified cells to sufficient numbers for transplantation. The successful accomplishment of the proposal will open new opportunities for developing somatic cell gene therapies for a variety of human diseases, including connective tissue disease, hematologic diseases and cancer.

PI_NAMEs: KOGUT, IGOR  (contact)

PROGRAM_OFFICER_NAME: BELKIN, ALEXEY

PROJECT_TERMS: Acceleration;Adult;adult stem cell;aged;Autologous Transplantation;Biological Assay;Birth;Burn injury;Cell Aging;Cell division;Cell Line;Cell Physiology;Cell Proliferation;Cell Reprogramming;Cell Transplantation;cell type;Cells;cellular engineering;Characteristics;chimeric antigen receptor T cells;chronic wound;Clinical;clinically relevant;Clonal Expansion;Complex;Connective Tissue Diseases;Data;Development;Disease;DNA Damage;drug testing;Elongation Factor;enzyme activity;Epigenetic Process;epigenome;epithelial stem cell;experimental study;Fibroblasts;Fluorescence;Foundations;Future;Gene Modified;Gene Targeting;Generations;Genes;Genetic;Genetic Engineering;genetically modified cells;Growth;Guide RNA;healing;Hematologic Neoplasms;Hematological Disease;Hematopoietic stem cells;Human;human adult stem cell;human disease;Human Engineering;improved;in vivo;Individual;induced pluripotent stem cell;induced pluripotent stem cell technology;keratinocyte;Knock-in;Legal patent;Length;Life;life span;Luciferases;Mediating;Mesenchymal;Mesenchymal Stem Cells;Messenger RNA;Mitochondrial DNA;mitochondrial dysfunction;mitochondrial metabolism;Molecular;Mus;muscle progenitor cell;normal aging;novel;novel strategies;nuclease;Older Population;Phenotype;Ploidies;Pluripotent Stem Cells;Premature aging syndrome;preservation;prevent;Proliferating;Proteins;Regenerative Medicine;Rejuvenation;Reporter;Research;response;restoration;RNA;Safety;senescence;Site;Skin graft;Somatic Cell;Somatic Gene Therapy;Source;stem;stem cells;Stromal Cells;System;T-Lymphocyte;Technology;technology platform;Telomerase;telomere;Telomere Maintenance;Telomere Shortening;Testing;Time;Tissue Engineering;Tissue Model;Tissues;Transcription Coactivator;Transfection;transplant model;Transplantation;Treatment Efficacy;Xenograft Model

PROJECT_TITLE: Developing a platform for human somatic cell rejuvenation, expansion and genetic engineering using synthetic RNA molecules

STUDY_SECTION: CMT

STUDY_SECTION_NAME: Cellular and Molecular Technologies Study Section[CMT]