NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Cardiovascular;Clinical Research;Heart Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Physical Activity;Prevention;Social Determinants of Health

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: PROJECT NARRATIVE The built environment—the buildings, streets, and green spaces in which we live—may influence cardiovascular disease (CVD) by promoting or limiting physical activity and weight gain and by shaping exposures to environmental hazards (e.g., air pollution, extreme temperatures, noise); however, developing accurate, time- varying, and personalized exposure metrics is necessary to build causal relationships between the built environment and CVD and to inform policy-relevant, actionable interventions. We propose to identify the influence of the built environment on CVD-related health behaviors and CVD incidence by developing longitudinal built environment exposure measures from street-view and satellite imagery using deep learning algorithms, and to apply these exposure measures to time-activity data from a) 500 participants with global positioning systems (GPS) data from the Nurses’ Health Study 3 (NHS3) and b) over 34 years of geocoded residential addresses from three large nationwide cohorts of over 288,000 US adult women and men from the Nurses’ Health Study, Nurses’ Health Study II, and Health Professionals Follow-up Study prospective cohorts. Our work will enable us to measure time-varying exposure to the built environment with unprecedented precision in large prospective cohorts, to elucidate potential relationships between the built environment and CVD health behaviors, to better specify pathways to CVD incidence, and ultimately, to yield actionable insights to guide land use policy and urban planning strategies to design cities that optimize cardiovascular health.

PI_NAMEs: JAMES, PETER  (contact)

PROGRAM_OFFICER_NAME: COADY, SEAN

PROJECT_TERMS: Address;Adult women;Air Pollution;Ancillary Study;built environment;Cardiovascular Diseases;cardiovascular health;Catalogs;Cellular Phone;Cessation of life;Cities;cohort;Computer Vision Systems;Coronary heart disease;Cross-Sectional Studies;Data;deep learning;deep learning algorithm;design;Environment;Environmental Hazards;Environmental Risk Factor;Exposure to;extreme temperature;follow-up;Follow-Up Studies;Global Positioning System;Green space;Health behavior;Health behavior change;Health Professional;Health Promotion;Health Technology;Image;Imagery;Incidence;Infrastructure;innovation;insight;Intervention;land use;Lived experience;Location;machine learning algorithm;Measures;men;Methods;mHealth;Myocardial Infarction;Noise;novel;Nurses' Health Study;Outcome;Participant;Pathway interactions;Patient Self-Report;Pattern;Perception;petabyte;Physical activity;Physical environment;Planet Earth;Policies;Population;Process;Prospective cohort;Prospective, cohort study;Questionnaires;Recording of previous events;residence;Resolution;Safety;Shapes;spatiotemporal;Specific qualifier value;Stroke;Time;Trees;urban area;urban planning;wearable device;Weight;Weight Gain;Work

PROJECT_TITLE: Built Environment Assessment through Computer visiON (BEACON): Applying Deep Learning to Street-Level and Satellite Images to Estimate Built Environment Effects on Cardiovascular Health

STUDY_SECTION: CHSB

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology B Study Section[CHSB]


ADMINISTERING_IC: GM

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Natural Products;Rare Diseases

ORG_CITY: AUSTIN

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

ORG_STATE: TX

PHR: Project Narrative: Polyketides are used more in human medicine than any other class of secondary metabolites, and comprise roughly 20% of top-selling small-molecule drugs. This project advances catalytic methods for the de novo chemical synthesis of polyketides based on hydrogen auto-transfer processes that enable direct stereo- and site-selective conversion of lower alcohols to higher alcohols. Polyketide natural products that possess anti-cancer and anti- bacterial properties are targeted.

PI_NAMEs: KRISCHE, MICHAEL J (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TITLE: Polyketides via Redox-Triggered Alcohol C-H Functionalization

STUDY_SECTION: SBCA

STUDY_SECTION_NAME: Synthetic and Biological Chemistry A Study Section[SBCA]


ADMINISTERING_IC: HL

FUNDING_MECHANISM: NON SBIR/STTR CONTRACTS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: DANA POINT

ORG_STATE: CA

PI_NAMEs: CARO, ELIAS  (contact)

PROJECT_TERMS: research and development;Small Business Innovation Research Grant;Training

PROJECT_TITLE: SCIENTIFIC ENTREPRENEURIAL C3I TRAINING


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: HIV/AIDS;Infectious Diseases;Pediatric;Pediatric - AIDS;Prevention

ORG_CITY: KENSINGTON

ORG_NAME: ADVANCED BIOSCIENCE LABORATORIES, INC.

ORG_STATE: MD

PI_NAMEs: SILVERA, PETER  (contact)

PROJECT_TERMS: Adolescent;Age;AIDS prevention;antiretroviral therapy;Child;Childhood;co-infection;Collaborations;Communities;Contraceptive Agents;Contracts;Development;Devices;Drug Formulations;experience;Extramural Activities;Formulation;HIV;Infant;Investigator-Initiated Research;Knowledge;Modeling;National Institute of Allergy and Infectious Disease;novel therapeutics;pediatric drug development;Pediatrics;pharmacometrics;pre-clinical;Prevention;Private Sector;product development;Regulatory Pathway;Research;research clinical testing;research study;Resources;Science;Services;therapeutic development

PROJECT_TITLE: Expertise in Development of Pediatric Drug Formulations


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Clinical Research

ORG_CITY: SILVER SPRING

ORG_NAME: SOCIAL AND SCIENTIFIC SYSTEMS,  INC.

PI_NAMEs: GLOVER, JAMIE  (contact)

PROJECT_TERMS: Advertising;Agreement;Award;Charge;Clinic;Clinical;Clinical Research;Clinics and Hospitals;Collaborations;community partners;Contract Services;Contractor;Contracts;cost effective;cost estimate;Data;Data Collection;data management;Employee;Enrollment;Equipment;Feasibility Studies;Generations;Health Personnel;Health protection;Infrastructure;Interview;Location;Logistics;Longitudinal Studies;Maintenance;Management Information Systems;Medical center;National Institute of Environmental Health Sciences;Office of Administrative Management;Personal Communication;Personally Identifiable Information;Pharmaceutical Preparations;Pilot Projects;Policies;Preparation;Principal Investigator;Printing;Procedures;Protocols documentation;Provider;Radio;Records;recruit;Reporting;Research;Research Institute;research study;Research Support;Resources;Safety Management;Sampling;Security;Services;Site;social media;Specimen Handling;supply chain;System;Telephone;Television;Training;Universities;Visit;Work

PROJECT_TITLE: TASK ORDER 1R - ADMINISTRATION ACTIVITIES AND SUPPORT


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Orphan Drug;Rare Diseases;Vector-Borne Diseases

ORG_CITY: MANASSAS

ORG_NAME: AMERICAN TYPE CULTURE COLLECTION

ORG_STATE: VA

PI_NAMEs: COUCH, HEATHER  (contact)

PROJECT_TERMS: Advanced Development;Anti-viral Agents;Basic Science;Biological Assay;Cell Line;Contracts;Development;Eastern Equine Encephalitis Virus;in vitro testing;Maintenance;Marburgvirus;pathogenic virus;Production;Viral;Virus

PROJECT_TITLE: Task B08: Production of Well Characterized Challenge Material (WCCM) for BSL-3/BSL-4 Viral Pathogens


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Burden of Illness;Cancer;Prevention;Social Determinants of Health

ORG_CITY: HONOLULU

ORG_NAME: UNIVERSITY OF HAWAII AT MANOA

ORG_STATE: HI

PI_NAMEs: HERNANDEZ, BRENDA  (contact)

PROJECT_TERMS: Annual Reports;anti-cancer research;Cancer Control;Cancer Patient;cancer statistics;Data;Diagnosis;Disease;Geography;Incidence;Infrastructure;insight;Malignant Neoplasms;Monitor;National Cancer Institute;Patients;Population;Prevalence;SEER Program;Social Characteristics;Subgroup;Time;treatment pattern;trend

PROJECT_TITLE: SEER CORE INFRASTRUCTURE SUPPORT


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: Rockville

ORG_NAME: DIGITAL INFUZION, INC.

PI_NAMEs: GOLTZ, BRETT  (contact)

PROJECT_TITLE: DESIGN/ADAPT, DEVELOP, MAINTAIN, AND OPERATE A UNIFIED CROMS THAT SUPPORTS THE UNIQUE DATA AND CLINICAL RESEARCH PROCESS. - Alzheimer's disease


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: INDIANAPOLIS

ORG_NAME: RLR VA MEDICAL CENTER

ORG_STATE: IN

PHR: Ensuring that colonoscopy is performed well is necessary for optimizing prevention of colorectal cancer (CRC). One of the most important ways of measuring the quality of colonoscopy is to see how often CRC occurs following an initial colonoscopy that does not show CRC, an entity known as “post-colonoscopy CRC” (PCCRC). We plan to: 1) measure how often PCCRCs occur in Veterans; 2) compare Veterans who have PCCRC with those who have an initially detected CRC for cancer stage, surgical complications, and survival; 3) identify factors associated with PCCRC, some of which may lend themselves to interventions that improve how colonoscopy is performed and how well follow-up occurs, measures that will make sure Veterans are receiving colonoscopy and follow-up of the highest quality.

PI_NAMEs: IMPERIALE, THOMAS F. (contact);KAHI, CHARLES JOSEPH

PROJECT_TERMS: Adherence;Affect;Age;aged;attributable risk;cancer diagnosis;cancer site;Case/Control Studies;Characteristics;Cohort Studies;Colonoscopy;Colorectal;Colorectal Cancer;colorectal cancer prevention;colorectal cancer risk;colorectal cancer screening;comorbidity;computer infrastructure;Cross-Sectional Studies;data repository;data warehouse;Databases;Detection;Development;Diagnosis;Diagnostic;Diagnostic Errors;Disease;Educational Status;effectiveness evaluation;Electronics;Ensure;Etiology;Excision;experience;Feces;follow-up;German population;Germany;Goals;Greenland;Guidelines;Healthcare;Healthcare Systems;Hospitalization;improved;Incidence;indexing;informatics infrastructure;Institution;Intervention;Knowledge;Lesion;Literature;Logistic Regressions;Malignant Neoplasms;Manuals;Measures;Medical Records;medical specialties;Methods;Modality;mortality;Multivariate Analysis;neoplasm registry;Neoplasms;Nested Case-Control Study;Occult blood screen;Odds Ratio;Operative Surgical Procedures;Outcome;Patient-Focused Outcomes;Patients;Performance;Polypectomy;polyposis;Polyps;Population;population based;Population Study;Postoperative Period;Preparation;Prevalence;primary outcome;Procedures;programs;Publishing;Recommendation;Research;Research Design;Resected;Retrospective cohort study;Risk;Risk Factors;Role;rurality;screening;secondary outcome;sex;Sigmoidoscopy;success;Surgical complication;survival outcome;System;Testing;Time;Translating;Veterans;Veterans Health Administration;Vital Status;Withdrawal

PROJECT_TITLE: Prevalence, Risk Factors and Outcomes of Post-colonoscopy Colorectal Cancer in Veterans

STUDY_SECTION_NAME: HSR-1 Health Care and Clinical Management[HSR1]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hearing Loss;Networking and Information Technology R&D (NITRD);Neurosciences;Prevention;Primary Health Care;Rehabilitation;Social Determinants of Health;Telehealth

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: R21 R33 Narrative Hearing loss is a major global health problem, especially in low and middle income countries where most people lack access to hearing health care. This proposal offers innovative mobile health solutions, focusing on the fitting and support of good quality low-cost hearing aids by community health workers. If successful, this approach could be scaled up to address hearing health care for underserved populations globally.

PI_NAMEs: MOORE, DAVID  (contact);SWANEPOEL, DEWET

PROGRAM_OFFICER_NAME: KING, KELLY ANNE

PROJECT_TERMS: Acclimatization;Address;Adoption;Africa South of the Sahara;Algorithms;Behavioral;Blinded;Caring;Cellular Phone;Child;Clinic;Clinical;Clinical Trials;Communication;Communities;community engagement;Community Health Aides;community setting;cost;Country;Data;data modeling;Decentralization;Detection;Devices;Diagnosis;Diagnosis Clinical Trials;Diagnostic;Differential Diagnosis;Digit structure;digital;disability;Ear;Equipment;Equity;evidence base;experience;Family;Foundations;functional outcomes;Funding;global health;Goals;grandchild;Healthcare;Hearing;Hearing Aids;hearing impairment;hearing screening;Hearing Tests;high standard;improved;Income;Individual;Industrialization;innovation;International;Intervention;Knowledge;Laboratories;Language;low and middle-income countries;Low income;Machine Learning;Medical;Methods;mHealth;mobile computing;Modeling;Noise;novel;Nursery Schools;Ohio;Otoscopy;Outcome;outreach;Participant;Patient Self-Report;Penetration;Performance;Persons;Phase;poor communities;Population;Procedures;Process;programs;Public Health;randomized, controlled study;Randomized, Controlled Trials;rehabilitation service;Rehabilitation therapy;response;scale up;School Teachers;segregation;Sensorineural Hearing Loss;Service delivery model;Services;smartphone application;sound;South African;speech in noise;Support System;Techniques;Technology;Testing;Text;texting support;Time;time use;Training;Training Activity;Translating;Triage;Underserved Population;United States National Institutes of Health;usability;Validation;Variant;Vision;Voice;Work;Writing

PROJECT_TITLE: Mobile technologies for delivering hearing care through community health workers

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-K(55)]


NIH_SPENDING_CATS: Genetics

ORG_CITY: STANFORD

ORG_DEPT: PHARMACOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE The initiation of DNA replication is tightly regulated to maintain genome integrity, yet the molecular mechanisms that underlie this fundamental process are poorly understood, especially in multicellular organisms. Key proteins involved in replication initiation are poorly conserved between yeast and humans, and mutations in these proteins cause genetic diseases. This project will employ a powerful single-molecule approach that we developed to dissect the mechanism of replication initiation, delineate the exact roles of replication initiation proteins, and understand why mutations in these proteins cause disease.

PI_NAMEs: CHISTOL, GHEORGHE  (contact)

PROGRAM_OFFICER_NAME: REDDY, MICHAEL K

PROJECT_TERMS: Biochemical;Biological Markers;cancer cell;Cell Proliferation;Disease;DNA analysis;DNA biosynthesis;DNA-Protein Interaction;Genetic;Genetic Diseases;Genome;genome integrity;Genome Stability;Human;imaging platform;insight;Laboratories;Life;Malignant Neoplasms;Methods;Molecular;Mutation;new therapeutic target;novel;Oncogene Activation;Organism;overexpression;Peptide Initiation Factors;Process;Proliferating;Proteins;rare genetic disorder;Regulation;Replication Initiation;Replication Origin;Role;single molecule;Structure;Time;Visualization;Work;Yeasts

PROJECT_TITLE: Structure-Function Analysis of DNA Replication Initiation Factors Implicated in Disease


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Asthma;Clinical Research;Genetics;Human Genome;Lung;Pediatric;Precision Medicine

ORG_CITY: Newark

ORG_DEPT: MISCELLANEOUS

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: PROJECT NARRATIVE Lung function is an important determinant of asthma, a disease with significantly increasing public health burden world-wide. This K99/R00 grant utilizes innovative analytic approach for multi-omic integration of metabolomic, methylomic and genetic drivers of sub-optimal lung function in asthmatic children; none of the studies so far have interrogated their joint role for lung function in asthmatics. The findings from this proposal will provide a better understanding of the mediated effects through multi-omic profiles for asthma pathogenesis and allow us to focus on the molecular intersection of potential biomarkers with predictive potential in dysregulated pathways and life- course interventions for individuals with asthma.

PI_NAMEs: KACHROO, PRIYADARSHINI  (contact)

PROGRAM_OFFICER_NAME: LU, JINING

PROJECT_TERMS: Address;Adolescence;Advisory Committees;Affect;Amino Acids;antenatal;Area;Asthma;asthmatic;Automobile Driving;Award;Bioinformatics;Biological Markers;biomarker driven;career;career development;Cell Survival;Child;Childhood;Childhood Asthma;Clinical;clinical phenotype;clinical training;clinical translation;cohort;Communication;Complement;Complex;Costa Rica;Data;Data Scientist;Data Set;Development Plans;Diagnosis;Disease;disease phenotype;DNA Integration;DNA Methylation;Doctor of Philosophy;Ensure;Environment;Environmental Exposure;Environmental Risk Factor;Epigenetic Process;Ethics;Future;Genes;Genetic;genetic epidemiology;Genetic Risk;genetic variant;Genetic Variation;Genome;genome sequencing;genome-wide;genome-wide analysis;Goals;Grant;Growth;Heritability;Hospitals;Impairment;Individual;innovation;insight;integration site;Intervention;Joints;Life;Life Cycle Stages;Link;Lung;lung development;Maps;Measures;Mediating;Mediation;medical schools;Medicine;Mentors;Mentorship;Metabolic Pathway;Metabolism;metabolome;metabolomics;Methodology;Methods;Methylation;methylome;methylomics;Molecular;Multiomic Data;multiple omics;Network-based;Obstructive Lung Diseases;Outcome;Pathogenesis;Pathway interactions;Phase;Phenotype;Play;Positioning Attribute;potential biomarker;programs;prospective;Public Health;pulmonary function;Pulmonary Function Test/Forced Expiratory Volume 1;Quantitative Trait Loci;Research;research and development;Research Design;Research Personnel;Risk;risk prediction;risk variant;Role;skills;Sphingolipids;success;Sum;Testing;Training;Training Support;Trans-Omics for Precision Medicine;Vitamin D;Whole Blood;whole genome;Woman

PROJECT_TITLE: Methylomic and metabolomic determinants of Lung Function in Asthmatics

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


FUNDING_MECHANISM: RESEARCH CENTERS

NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Immunotherapy;Lung;Lung Cancer;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Immunotherapy development relies on the preclinical validation of anti-tumor immune responses in patient derived xenograft (PDX) models. The current PDX models generally lack an autologous human immune system (HIS) and are difficult to reconstitute directly with non-matching human immune cells. We propose to optimize the conditions to generate reprogrammed cells from the same cancer patient and utilize these cells to generate a panel of matched HIS-PDXs to disseminate to the scientific community through the NCI Patient Derived Model Repository (PDMR) for use in testing immune responses and advancing immunotherapy and oncology research.

PI_NAMEs: SCHULICK, RICHARD D (contact)

PROGRAM_OFFICER_NAME: HE, MIN

PROJECT_TERMS: Alleles;anti-tumor immune response;Antibody-drug conjugates;Autologous;biobank;Biological Assay;Biopsy;Blood;Blood Cells;Bone Marrow;Bone Marrow Cells;Cancer Center Support Grant;cancer immunotherapy;Cancer Patient;capsule;Carcinoma;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cell Line;Cell Maturation;Cell Reprogramming;Cells;Clinic;Collaborations;Colorado;Communities;Data;design;Development;differentiation in vitro;Endothelial Cells;Engraftment;Evaluation;Fibroblasts;Generations;genome sequencing;Goals;graft versus host disease induction;graft vs host disease;Hematopoietic stem cells;Human;humanized mouse;Immune;Immune checkpoint inhibitor;immune resistance;Immune response;Immune system;immunodeficiency;Immunodeficient Mouse;Immunologic Markers;Immunologic Monitoring;Immunologic Surveillance;Immunologic Tests;Immunotherapy;Implant;improved;in vivo;in vivo engraftment;induced pluripotent stem cell;Knowledge;Lead;Lymphocyte;Malignant neoplasm of lung;Malignant Neoplasms;Mature T-Lymphocyte;Mediating;Modeling;Mus;Myelogenous;Myeloid Cells;Natural Killer Cells;neoplastic cell;Nivolumab;Non-Small-Cell Lung Carcinoma;novel;Oncogenic;Oncology;Organoids;patient derived xenograft model;Patients;Peripheral Blood Mononuclear Cell;Plasma;pre-clinical;Pre-Clinical Model;precision medicine;Prediction of Response to Therapy;Procedures;programmed cell death ligand 1;reconstitution;repository;Research;Resistance;resistance mechanism;Resolution;response;risk mitigation;RNA;Skin;Specimen;standard of care;stem cell model;stem cell organoids;System;T cell differentiation;T-Cell Activation;T-Cell Depletion;T-Lymphocyte;Technology;Testing;Thymic Tissue;Thymus Gland;Tissues;tumor;tumor-immune system interactions;Universities;Validation;Variant;whole genome;Work

PROJECT_TITLE: University of Colorado Cancer Center Support Grant - Lung Cancer Patient-Derived Xenografts with Autologous Human Immune Systems


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS EYE AND EAR INFIRMARY

ORG_STATE: MA

PHR: Project Narrative Retinitis Pigmentosa is a blindness disease in which rod photoreceptors, which are necessary for night vision, degenerate due to inherited mutations, and subsequently, cone photoreceptors, which provide humans with daylight color vision, degenerate for unknown secondary reasons. In mouse models of Retinitis Pigmentosa, which recapitulate the human disease progression, the barrier that separates the blood from the retina begins to break down once rod photoreceptors degenerate. By determining whether such blood leakage causes cone death, this proposed research aims to develop novel therapeutic approaches to promote cone survival, leading to the preservation of daylight color vision.

PI_NAMEs: AMAMOTO, RYOJI  (contact)

PROGRAM_OFFICER_NAME: NEUHOLD, LISA

PROJECT_TERMS: Age;Antibodies;Blindness;Blood;Blood - brain barrier anatomy;Blood Vessels;Blood-Retinal Barrier;career;cell type;Cells;cellular targeting;Central Nervous System;Cessation of life;Choroid;Color Visions;Cone;Detection;Dextrans;Disease;Disease Progression;Etiology;Excision;Exhibits;experimental study;Extravasation;Foundations;Future;gene replacement therapy;gene therapy;Genes;Genotype;Goals;Grant;Heme;Heterogeneity;Human;human disease;Immune;immune cell infiltrate;Immunofluorescence Immunologic;Immunoglobulin G;Infiltration;Inherited;Link;Literature;medical schools;Molecular;mouse model;Mus;Mutate;Mutation;Natural Killer Cells;Neurodegenerative Disorders;neuron loss;Neurons;novel therapeutic intervention;Patients;Peripheral;Permeability;Persons;Phase;Phenotype;photoreceptor degeneration;Play;postnatal;preservation;prevent;Proteins;Quality of life;Research;Retina;retina blood vessel structure;Retinal Cone;Retinal Degeneration;Retinal Diseases;retinal rods;Retinitis Pigmentosa;Rod;Role;role model;Signal Transduction;success;Supporting Cell;Therapeutic;therapeutic target;Time;Tissues;Tracer;Training;Vision;Weight;Work

PROJECT_TITLE: Elucidating the molecular and cellular mechanisms underlying cone survival in the peripheral retina in mouse models of Retinitis Pigmentosa


ADMINISTERING_IC: AG

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_CITY: LAWRENCE

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF KANSAS LAWRENCE

ORG_STATE: KS

PHR: PROJECT NARRATIVE The continual trend of “lost in translation” in the search for a successful treatment for Alzheimer’s disease (AD) calls for innovative approaches before a viable drug target is established. The outcomes of this research will yield valuable insights into whether a therapeutic shield such as a human ApoE2- based protein therapy that promotes brain metabolic resilience can potentially be developed into an effective and safe disease-modifying strategy for AD, which is vital to the present fight against this devastating and currently untreatable disease.

PI_NAMEs: SIAHAAN, TERUNA J.;ZHAO, LIQIN  (contact)

PROGRAM_OFFICER_NAME: GROTHAUS, PAUL G

PROJECT_TERMS: Adverse reactions;Age;aging brain;Alzheimer's Disease;Alzheimer's disease brain;Apolipoprotein E;apolipoprotein E-2;apolipoprotein E-3;apolipoprotein E-4;Biological;Blood - brain barrier anatomy;Brain;Cadherins;Deposition;Development;Disease;Drug Targeting;familial Alzheimer disease;fighting;Genotype;Glucose;Glycoproteins;Goals;high risk;Hippocampus;Human;humanized mouse;improved;innovation;insight;Intervention;Knock-in Mouse;Mediating;Metabolic;Metabolism;Methods;mouse model;mutant;neuroprotection;novel;Outcomes Research;Pathogenesis;Physiological;Preparation;prevent;Production;Proteins;proteostasis;Recombinants;Regimen;Research;Research Project Summaries;resilience;sex;Shapes;Signal Transduction;success;Synapses;Therapeutic;Translating;Translations;trend;Up-Regulation

PROJECT_TITLE: Reshaping ApoE4 and Alzheimer's Brains with ApoE2


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Breast Cancer;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: PROJECT NARRATIVE Adverse social conditions contribute to poor breast cancer outcomes among Black women. This study will collect and analyze data from surveys, biospecimens, and focus groups among Black women with breast cancer to study associations between social determinants of health, biomarkers of inflammation, and health-related quality of life. Study findings will increase understanding of how social factors may contribute to racial disparities in breast cancer and help identify strategies to improve health outcomes among Black women with breast cancer.

PI_NAMEs: NELSON, WILLIAM GEORGE (contact)

PROGRAM_OFFICER_NAME: BELIN, PRECILLA L

PROJECT_TERMS: age group;analytical method;Area;Biological Markers;Black race;black subgroup;black women;Blood specimen;Breast Cancer survivor;Data;data integration;Death Rate;Ethnic Population;Focus Groups;Health;health related quality of life;Heterogeneity;improved;Individual;Inflammation;Inflammatory;insight;interest;Laboratories;Lived experience;Malignant Breast Neoplasm;Malignant Neoplasms;Maryland;Measures;Oncology;Outcome;parent grant;Participant;Pathway interactions;Patient Outcomes Assessments;protein biomarkers;racial disparity;racial population;recruit;Research;research study;residence;response;Sampling;Social Conditions;social factors;social health determinants;sociodemographics;Socioeconomic Status;Source;Structural Racism;Surveys;Survivors;United States;Women's Group

PROJECT_TITLE: Regional Oncology Research Center (Heterogeneity)

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Influenza;Patient Safety;Pneumonia and Influenza

ORG_CITY: COLUMBIA

ORG_NAME: ADVARRA, INC.

PI_NAMEs: ATKINSON, REBECCA  (contact)

PROJECT_TERMS: Birds;Clinical Trials;Communicable Diseases;Influenza A virus;Influenza A Virus, H5N1 Subtype;Institutional Review Boards;National Institute of Allergy and Infectious Disease;Services;Site

PROJECT_TITLE: Single Institutional Review Board (sIRB)


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Infectious Diseases;Patient Safety

PROJECT_TERMS: biobank;Clinical Trials;Communicable Diseases;Institutional Review Boards;National Institute of Allergy and Infectious Disease;Support Contracts


NIH_SPENDING_CATS: Aging;Genetics;Machine Learning and Artificial Intelligence

ORG_CITY: SEATTLE

ORG_NAME: INSTITUTE FOR SYSTEMS BIOLOGY

ORG_STATE: WA

PHR: Project Narrative This project aims to develop a new tool to assess the overall health of a mouse and predict early in a mouse's life when it will die. This assessment will be an important tool for the aging research field to increase the efficiency of studies looking at interventions to delay aging.

PI_NAMEs: KANE, ALICE E (contact)

PROGRAM_OFFICER_NAME: FU, YI-PING

PROJECT_TERMS: accelerated epigenetic aging;Acceleration;Age;age acceleration;Age Months;age related;Age related pathologies;Aging;Attenuated;Award;Behavior;Behavioral;biological age;Biological Markers;Biology of Aging;Blood;C57BL/6 Mouse;Caloric Restriction;career;Cessation of life;Chromatin;Chronology;Clinical;clinically relevant;Collection;Complete Blood Count;Computer Models;Consumption;cost;cost effective;data integration;Detection;Development;differential expression;DNA;DNA Methylation;Electrocardiogram;Elements;epigenetic aging;epigenetic clock;Epigenetic Process;epigenome;Female;Fractionation;frailty;Gait;Goals;Health;health assessment;Health Status;healthspan;Heterogeneity;histone modification;Histones;Human;indexing;Individual;innovation;International;Intervention;Investigation;Kinetics;Life;life span;liquid chromatography mass spectrometry;Longevity;longitudinal analysis;Machine Learning;machine learning algorithm;machine learning model;male;Measures;medical schools;Mentors;Methodology;Methods;Methylation;Modeling;Molecular;Molecular Weight;mortality;mouse model;Mus;novel;old mice;Outcome;Outcome Measure;Peptides;Persons;Phase;Phenotype;Physiological;Plasma;Positioning Attribute;Postdoctoral Fellow;pre-clinical;Proteins;Reproducibility;Research;Research Personnel;Sampling;sex;Site;Skin Tissue;Statistical Models;Testing;Time;Tissues;tool;Training;Transgenic Organisms;Work

PROJECT_TITLE: Development of a Predictive Frailty Clock & Longitudinal Investigation of its Epigenetic Determinants


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Dementia;Depression;Mental Health;Mental Illness;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: LA JOLLA

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE It has been well documented that depression is a risk factor for dementia; however, the reasons for this relationship are multifaceted as depressive symptoms may be causal and lead to cognitive decline or they could be an early symptom of a neurodegenerative process occurring later in life. To help clarify this relationship, the current study will examine the extent to which mid-life and late-life onset of depressive symptoms relate to subtle cognitive decline subtypes (i.e., low-executive), progression to cognitive impairment, and unique biological and neural profiles. Further clarifying the underlying causes that link depressive symptoms and cognitive decline would help to clarify the reasons for the depression-dementia relationship and potentially identify individualized targets for intervention based on the time of depression onset and a person’s cognitive and biomarker profile.

PI_NAMEs: THOMAS, KELSEY R (contact)

PROGRAM_OFFICER_NAME: ANDERSON, DALLAS

PROJECT_TERMS: Aging;Alzheimer's disease related dementia;Atherosclerosis Risk in Communities;Baltimore;Biological;Biological Markers;Blood Vessels;career;chronic depression;Cognition;Cognitive;cognitive performance;Communities;Data;Dementia;dementia risk;depressive symptoms;Fellowship;Funding;geriatric depression;Goals;Health;Heterogeneity;Impaired cognition;Inflammatory;inflammatory marker;Intervention;K-Series Research Career Programs;late life;Life;Link;Longitudinal Studies;Mediating;Memory;Mental Depression;Mentorship;middle age;mild cognitive impairment;Nerve Degeneration;neural;neural network;neuroimaging;neuromechanism;neuropsychiatry;novel;older adult;Outcome;parent grant;Parents;personalized medicine;Persons;Phenotype;Physical activity;Plasma;Postdoctoral Fellow;predictive marker;Process;programs;Research;Research Personnel;Role;skills;Statistical Data Interpretation;Symptoms;Time;tool;Training;treatment planning

PROJECT_TITLE: Heterogeneity of subtle cognitive decline phenotypes in community-dwelling older adults


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Neurosciences;Serious Mental Illness;Tourette Syndrome

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: NARRATIVE Tic disorders and obsessive-compulsive disorder are commonly comorbid and are thought to have overlapping pathophysiology in the cortico-basal ganglia circuitry. Work in an animal model of pathophysiology and pilot data in subjects with tics and OCD have identified previously uncharacterized abnormalities in dopamine D2 and D3 receptors. We will use state-of-the-art positron emission tomography (PET) imaging to examine these receptors in vivo in the brains of individuals with tics, OCD, or both; this will characterize these systems in tic disorders and OCD for the first time and has the potential to elucidate targets for novel treatments, and to identify the particular patients who might benefit from them.

PI_NAMEs: PITTENGER, CHRISTOPHER JOHN (contact)

PROGRAM_OFFICER_NAME: WIJTENBURG, SARAH ANDREA

PROJECT_TERMS: Address;Adult;Agonist;Alleles;Anhedonia;Animal Model;antagonist;Basal Ganglia;Behavior;Behavioral;Binding;Brain;Categories;Characteristics;Chronic;Clinical;clinically significant;comorbidity;Comparative Study;compulsion;Corpus striatum structure;Data;Data Set;Development;Diagnosis;Diagnostic;Disease;Dissociation;Dopamine;Dopamine D2 Receptor;Dopamine Receptor;Drug Targeting;Functional disorder;Ganglia;Genes;Genetic;genetic architecture;Genetic study;Gilles de la Tourette syndrome;Globus Pallidus;Histidine Decarboxylase;Human;Image;imaging study;in vivo;independent component analysis;Individual;individualized medicine;insight;Intervention;Knockout Mice;Knowledge;Ligands;Measures;Methodology;Modeling;Morbidity - disease rate;mouse model;Mus;Mutation;Nature;neurochemistry;neuroeconomics;neuropsychiatric disorder;neuropsychiatry;Nonsense Mutation;novel;Nucleus Accumbens;Obsession;Obsessive-Compulsive Disorder;Patients;Pattern;Penetrance;Positron-Emission Tomography;putamen;Raclopride;receptor;receptor binding;recruit;response;reward processing;Severities;Signal Transduction;Structure;Substantia nigra structure;symptomatology;Symptoms;Syndrome;System;Testing;Thalamic structure;Tic disorder;tic related;Time;Tracer;Translations;Up-Regulation;Ventral Striatum;Work

PROJECT_TITLE: Dysregulation of dopamine receptors in the basal ganglia in OCD and tic disorders: Positron Emission Tomography with [11C]-PHNO

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE Liver cancer, also known as hepatocellular carcinoma (HCC), is the fastest growing cause of cancer-related deaths among Americans with liver disease. Fatty liver disease related to metabolic dysfunction (e.g., diabetes, obesity), also called MAFLD or MASLD, has become the most common liver disease in the world. Our research using multilevel factors characterizing genetic ancestries and neighborhood socioeconomic disadvantage aims to address important gaps in our understanding of heterogeneity in HCC risk within Hispanic populations with cirrhosis.

PI_NAMEs: EL-SERAG, HASHEM B (contact)

PROGRAM_OFFICER_NAME: UMAR, ASAD

PROJECT_TERMS: Address;Administrative Supplement;admixture mapping;Affect;American;Biological Markers;Cancer Etiology;Cessation of life;Chemoprevention;Cirrhosis;cohort;Diabetes Mellitus;Early Diagnosis;Epidemic;European ancestry;fatty liver disease;Functional disorder;Genetic;Goals;Heterogeneity;high risk;Hispanic;Hispanic Populations;Indigenous;Individual;interest;Investigation;Joints;Liver diseases;Malignant neoplasm of liver;Measurement;Metabolic;Metabolic dysfunction;Metabolic syndrome;metabolic-associated fatty liver disease;mortality;multi-ethnic;neighborhood disadvantage;Neighborhoods;Obesity;parent grant;parenting intervention;Patients;Persons;Population;Prevention;Preventive measure;Primary carcinoma of the liver cells;programs;protective factors;Research;response;Risk;Risk Factors;socioeconomic disadvantage;Texas;trait;Work

PROJECT_TITLE: Multilevel factors associated with heterogeneity in risk of liver cancer within Hispanics with cirrhosis


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Sleep Research;Social Determinants of Health;Women's Health Research

ORG_DEPT: NEUROSCIENCES

PHR: Project Narrative: This study addresses the association between obstructive sleep apnea (OSA) and Alzheimer's disease (AD) risk, focusing on Black women who are underrepresented and at heightened risk. The research expands the parent grant by examining the moderating effect of OSA on the link between inflammation and cognitive performance, as well as determining if OSA mediates the relationship between neighborhood factors and cognition in Black women. Leveraging a community-based approach, the study incorporates both sleep variables and subjective neighborhood factors to comprehensively assess the multifaceted determinants of AD risk among an underserved population.

PI_NAMEs: BANKS, SARAH  (contact);SUNDERMANN, ERIN ELIZABETH

PROGRAM_OFFICER_NAME: WAGSTER, MOLLY V

PROJECT_TERMS: actigraphy;Address;Affect;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease risk;Alzheimer’s disease biomarker;analytical method;Area;Biological;Black Populations;Black race;black women;Blood;Brain region;Characteristics;Clinical;Clinical Management;Clinical Research;Cognition;cognitive benefits;cognitive function;cognitive performance;cognitive testing;Collection;Communities;Complement;Confidence Intervals;Consent;Cross-Sectional Studies;Data;Data Analytics;Dementia;deprivation;design;Devices;Disparity;follow-up;Future;Goals;Growth;high risk population;Home;Impaired cognition;indexing;Inflammation;Instruction;Intercept;Learning;Life Style;Linear Regressions;Link;longitudinal analysis;Measures;Mediating;Mediation;Mediator;Modeling;modifiable risk;Moods;neighborhood disadvantage;Neighborhoods;Nerve Degeneration;Obstructive Sleep Apnea;Output;parent grant;Perception;Predisposition;Prevention;Process;Questionnaires;Research;Research Design;Research Personnel;Risk;Risk Factors;Role;Sampling;secondary analysis;Severities;Site;Sleep;Sleep Apnea Syndromes;Sleep disturbances;social cohesion;social deficits;socioeconomic disadvantage;socioenvironmental factor;Specific qualifier value;tau function;tau-1;Testing;Therapeutic Trials;Time;Training;Underserved Population;United States National Institutes of Health;Visit;Visualization

PROJECT_TITLE: Understanding Biological and Lifestyle Contributions to Alzheimer's Disease Pathology and Clinical Profiles in Black Women: Defining Prevention Targets in High Risk Groups


ADMINISTERING_IC: OD

FUNDING_MECHANISM: OTHERS

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Data Science;Networking and Information Technology R&D (NITRD)

ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PI_NAMEs: MA'AYAN, AVI  (contact);SUBRAMANIAM, SHANKAR

PROGRAM_OFFICER_NAME: KANO, KRISTIN KATHLEEN

PROJECT_TERMS: Address;Adopted;Architecture;Archives;Benchmarking;bioinformatics tool;Biological Assay;Biomedical Research;Cataloging;Catalogs;cell type;chatbot;Complex;Computer software;cost;Data;data analysis pipeline;Data Coordinating Center;data ecosystem;data ingestion;data integration;data modeling;data portal;data resource;Data Set;data tools;Databases;Dedications;design;digital;Ecosystem;Education;Education and Outreach;Electronic Mail;Elements;Event;experience;Feedback;Feeds;Funding;Funding Opportunities;Genes;Genus Mentha;Goals;Graph;Group Meetings;Home;indexing;Ingestion;Knowledge;knowledge graph;Knowledge Portal;Learning;Libraries;Link;LinkedIn;Machine Learning;meetings;Metadata;Methods;news;Pharmaceutical Preparations;Phase;Play;preservation;Process;Productivity;programs;Protocols documentation;Publications;Publishing;repository;Research Personnel;Resources;search engine;Site;social media;Social Network;System;Time;tool;transcriptome sequencing;Twitter;United States;United States National Institutes of Health;virtual;Visualization;web app;web portal;Work;working group

PROJECT_TITLE: The CFDE Workbench

STUDY_SECTION: CFOT

STUDY_SECTION_NAME: Common Fund Other Transactions Programs[CFOT]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Dissemination and Implementation Research;Drug Abuse (NIDA only);HIV/AIDS;Harm Reduction for Substance Misuse;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Methamphetamine;Prevention;Rural Health;Social Determinants of Health;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: NARRATIVE The use of drugs to enhance sex (sexualized drug use (SDU), chemsex) is a practice among some men who have sex with men (MSM) and this positions them at greater risk for HIV/STI transmission, injection drug use, and polysubstance use. This supplement candidate and parent grant PIs bring together a team of investigators with expertise in harm reduction implementation and social networks, clinicians who serve people who use drugs and LGBTQ+ patients, and community partners that understand and recognize the multiple complexities that surround substance use, specifically in the context of chemsex. Together, we propose a novel study of rural SDU/chemsex engagement among people who use drugs with the intention of evaluating secondary distribution of harm reduction and network influences among this population.

PI_NAMEs: MACKESY-AMITI, MARY ELLEN;PHO, MAI TUYET (contact)

PROGRAM_OFFICER_NAME: ZUR, JULIA BETH

PROJECT_TERMS: 4-hydroxybutyric acid;addiction;Address;Administrative Supplement;Attitude;Baseline Surveys;Behavior;behavior change;Caring;Cellular Phone;Characteristics;Communication;Communities;community partners;Complex;Data;Decision Making;digital;Disease Outbreaks;Disparate;Disparity;Drug usage;drug use behavior;drug use vulnerability;Drug user;Equipment and supply inventories;Evaluation;evidence base;Face;Fentanyl;follow-up;Funding;Future;Geography;Harm Reduction;Health;health disparity;Healthcare;Hepatitis C Incidence;high risk;HIV;HIV/HCV;HIV/STD;implementation evaluation;implementation framework;implementation strategy;improved;Individual;Infection;informant;injection drug use;Intention;Intervention;Interview;Investigation;Knowledge;learning community;Lesbian Gay Bisexual Transgender Queer;Link;Mail Order;Medical;medication compliance;men;men who have sex with men;Methamphetamine;methamphetamine use;Methamphetamine use disorder;Methods;Minority;Modeling;Morbidity - disease rate;mortality;Motivation;naloxone dispensing;Nature;Needle Sharing;Needle-Exchange Programs;Needs Assessment;novel;opioid epidemic;Outcome;Overdose;overdose death;overdose education;pandemic disease;parent grant;Parents;Participant;Pathway Analysis;Patients;peer;peer networks;Persons;Pharmaceutical Preparations;Play;pleasure;polysubstance use;Population;Positioning Attribute;pre-exposure prophylaxis;Privacy;Process;Public Health;Research;Research Personnel;Resources;Risk;Risk Factors;Risk Reduction;Rural;rural area;Rural Community;rural counties;rural drug use;rural dwellers;rural environment;Rural Population;rural setting;Secondary to;service delivery;service organization;service providers;Service provision;service uptake;Services;sex;sexual assault;sildenafil;smartphone based assessment;social;Social Network;social stigma;Social support;Structure;substance use;support network;Survey Methodology;Surveys;synthetic opioid;Testing;Theft;transmission process;Transportation;Travel;Unsafe Sex;urban area;Work

PROJECT_TITLE: Promoting remote harm reduction and secondary services in rural settings (PROMOTE) study


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Rare Diseases;Tuberculosis

ORG_DEPT: BIOLOGY

PHR: Project Narrative  Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), is one of the deadliest pathogens on the planet, and TB is one of the leading causes of death due to infectious disease. The cell envelope of Mtb forms a barrier around the cell, protecting the bacterium from antibiotics and our immune system. We will study protein-based systems that facilitate the transport of nutrients across the cell envelope, including the building blocks of the barrier itself, which may aid in the design of new antibiotics to treat TB.

PI_NAMEs: BHABHA, GIRA  (contact);EKIERT, DAMIAN CHARLES

PROGRAM_OFFICER_NAME: ROBINSON, RICHARD THOMAS

PROJECT_TERMS: Antibiotics;Architecture;Bacteria;Binding;Biochemical;Biological Assay;Cause of Death;cell envelope;Cells;Cellular Membrane;Cholesterol;combat;Communicable Diseases;Complex;Complex Analysis;Cryoelectron Microscopy;design;Development;Drug resistance;Environment;Escherichia coli;Fatty Acids;gene product;Genes;Genus Mycobacterium;Gram-Negative Bacteria;Growth;Hydrophobicity;Immune response;Immune system;In Vitro;Individual;insight;Learning;Link;lipid transport;Lipids;Lung;Macrophage;Maintenance;Mammalian Cell;Mass Spectrum Analysis;Membrane;membrane biogenesis;Modeling;Multiprotein Complexes;Mutation;mycobacterial;Mycobacterium smegmatis;Mycobacterium tuberculosis;Nutrient;Operon;particle;pathogen;Pathogenesis;Phagosomes;Planets;Play;polypeptide;protein complex;Protein Family;protein function;protein protein interaction;protein structure;Protein Subunits;protein transport;Proteins;Proteomics;resistant strain;Role;structural biology;Structure;System;Testing;Time;trafficking;Tuberculosis;tuberculosis treatment;Virulence;Virulence Factors;Work

PROJECT_TITLE: Structural characterization of MCE transport systems from Mycobacterium tuberculosis

STUDY_SECTION: PCMB

STUDY_SECTION_NAME: Prokaryotic Cell and Molecular Biology Study Section[PCMB]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

ORG_CITY: PITTSBURGH

ORG_NAME: CARNEGIE-MELLON UNIVERSITY

ORG_STATE: PA

PHR: Project Narrative Gene editing systems such as CRISPR are useful for developing immune cell therapies, but clinical applications frequently require processing billions of cells outside the body and current methods are not able to directly deliver DNA-editing proteins into large numbers of cells. The proposed project will develop a very fast method of stretching cell membranes to create temporary pores, facilitating the delivery of proteins which cut DNA and control DNA repair. This nonviral approach of quickly delivering biomolecules into billions of human immune cells will be valuable for efficiently producing immune cell therapies at clinical scales.

PI_NAMEs: SEVENLER, DERIN  (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Address;Allogenic;Biological;Biological Assay;Biomanufacturing;Biomedical Engineering;Biophysics;Biopolymers;CD8B1 gene;cell injury;cell killing;Cell membrane;Cell Therapy;Cells;Cellular immunotherapy;Charge;chimeric antigen receptor;chimeric antigen receptor T cells;Clinic;Clinical;clinical application;Clustered Regularly Interspaced Short Palindromic Repeats;Communicable Diseases;CRISPR/Cas technology;Cytosol;Dana-Farber Cancer Institute;Data;Devices;Dextrans;Disease;DNA;DNA delivery;DNA Repair;Drug Delivery Systems;Electroporation;Emerging Technologies;endonuclease;engineered T cells;Ensure;exhaustion;Face;Frequencies;Future;Gene Delivery;gene editing technology;gene therapy;General Hospitals;Genes;genomic locus;Goals;Human;Immune;immunocytochemistry;Immunology;improved;In Vitro;in vivo;innovation;interest;Jurkat Cells;Knock-out;knockout gene;Knowledge;Lead;Lentivirus Vector;Life;Liquid substance;Malignant Neoplasms;Measures;Medical;medical schools;Medicine;Mentors;Methods;Microfluidics;Molecular;Mus;nanoscale;neoplastic cell;Oncology;Operative Surgical Procedures;Permeability;Phase;Phenotype;Predisposition;Production;programs;Proteins;RAD52 gene;Reading;Reagent;receptor expression;repaired;Research;Retroviral Vector;Ribonucleoproteins;Safety;scale up;skills;Stretching;Surface;Suspensions;synthetic biology;System;Systems Biology;T cell therapy;T-Cell Activation;T-Cell Receptor;T-Lymphocyte;Technology;technology platform;Time;Touch sensation;Training;Transfection;Translating;Transplantation;tumor;vector;Viral Vector;viscoelasticity;Writing

PROJECT_TITLE: Intracellular delivery of DNA-editing proteins by viscoelastic cell stretching

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases B Research Study Section[MID-B]


NIH_SPENDING_CATS: Immunotherapy;Infectious Diseases

ORG_CITY: MEMPHIS

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

ORG_STATE: TN

PHR: Project Narrative The ability of T cells to destroy target cells (e.g., virus infected cells and tumor cells) critically depends on the CD28 costimulatory receptor, but the mechanism by which CD28 is activated in peripheral tissues is unknown since target cells do not display CD28 ligands. Guided by my preliminary data, this proposal aims to dissect a novel cell-intrinsic mechanism of CD28 cis-activation by its ligands expressed on T cells. Execution of the proposed research will define a new dimension of CD28 co-stimulation, and likely reveal innovative means for improving T cell based therapies against cancer and infectious diseases.

PI_NAMEs: ZHAO, YUNLONG  (contact)

PROGRAM_OFFICER_NAME: DECKHUT-AUGUSTINE, ALISON M

PROJECT_TERMS: Ablation;Address;Affect;Antigen-Presenting Cells;antigen-specific T cells;Ants;Award;base;Binding;Biological Assay;California;career;career development;Career Mobility;CD28 gene;Cells;Chronic Disease;Communicable Diseases;cytokine;Cytomegalovirus Infections;Data;Development Plans;Dimensions;Dissection;effector T cell;Ensure;Environment;Equilibrium;Exclusion;experimental study;Fluorescence Resonance Energy Transfer;Foundations;Goals;Health;Human;immune checkpoint blockade;Immune response;Immunologic Receptors;Immunotherapy;improved;In Vitro;in vivo;Infection;innovation;insight;Interleukin-2;Investigation;Knowledge;Life;Ligands;Liposomes;Malignant Neoplasms;Measures;Mediating;Membrane;Mentorship;Modeling;Molecular;Murid herpesvirus 1;Mus;Mutagenesis;neoplastic cell;novel;overexpression;Paper;Pathway interactions;Peripheral;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphotransferases;Positioning Attribute;post-doctoral training;Production;Proliferating;Proteins;PTPRC gene;Publishing;receptor;Receptor Activation;Receptor Signaling;reconstitution;recruit;Research;Research Personnel;Research Training;Resource Development;Role;segregation;Series;Signal Pathway;Signal Transduction;skills;Solid;success;superresolution microscopy;System;T cell regulation;T cell therapy;T-Cell Activation;T-Cell Receptor;T-Lymphocyte;Therapeutic;Tissues;tool;Training;tumor;Universities;Virus;Virus Diseases;Western Blotting

PROJECT_TITLE: Cis-interaction mediated CD28 costimulation

STUDY_SECTION: AITC

STUDY_SECTION_NAME: Allergy, Immunology, and Transplantation Research Committee[AITC]


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Kidney Disease;Lupus

ORG_CITY: NEW ORLEANS

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: PROJECT NARRATIVE: Lupus nephritis is a severe manifestation of systemic lupus erythematosus associated with significant morbidity and mortality. This project will establish sugar modifications in immunoglobulins that initiate processes within the blood filtering cells of the kidney, known as podocytes, which lead to lupus nephritis. This information will generate new insights and advanced concepts to expand the mechanistic understanding and therapeutic targets for these patients and treat them more efficiently.

PI_NAMEs: BHARGAVA, RHEA  (contact)

PROGRAM_OFFICER_NAME: RICE, JEFFREY S

PROJECT_TERMS: Advisory Committees;Affinity;aggressive therapy;Antigen-Antibody Complex;Area;Attenuated;Autoimmunity;Binding;Biological Markers;Biology;Biopsy;blood filter;C-Type Lectins;Ca(2+)-Calmodulin Dependent Protein Kinase;Calcium;Calcium Signaling;career;Caring;Cells;Clinical;clinical remission;Clinical Research;cohort;Complication;Data;Death Rate;Deposition;design;Development;diagnostic tool;diagnostic value;Disease remission;End stage renal failure;Excision;experimental group;experimental study;Exposure to;Fucose;Functional disorder;Galactose;Genetic;Glycoside Hydrolases;glycosylated IgG;glycosylation;Goals;Hand;healthy volunteer;Immune;Immunoglobulin G;Immunoglobulins;Immunology;indexing;Individual;Injury;innovation;insight;Kidney;kidney cell;Kidney Diseases;Knowledge;Laboratories;Lead;Learning;Lectin;liquid biopsy;Lupus Nephritis;lupus prone mice;Measurement;Measures;Mediating;Membrane;Mentorship;Modification;Morbidity - disease rate;mortality;Nephritis;Nephrology;Pathogenesis;Pathogenicity;Pathology;Patient Recruitments;Patients;Pattern;Pharmaceutical Preparations;pharmacologic;Phase;Physicians;podocyte;Polysaccharides;Population;Positioning Attribute;Preparation;prevent;Prevention;Process;prospective;Prospective Studies;Protein Kinase;Protein-Serine-Threonine Kinases;recruit;Renal function;Research;Research Project Summaries;Research Proposals;Risk;Role;Scheme;Scientist;Serology;Serum;Signal Transduction;sugar;SYK gene;System;systemic autoimmunity;Systemic Lupus Erythematosus;Techniques;tenure track;Testing;therapeutic target;Training;Translating;translational research program;treatment response;Up-Regulation;Urine;Work

PROJECT_TITLE: IgG glycosylation in lupus nephritis


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases;Prevention

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: Project Narrative The rise of multidrug-resistant organisms (MDRO) in recent decades represents a significant public health concern, associated with increased rates of mortality and healthcare costs. The proposed research will adapt wastewater-based surveillance to the detection of MDRO, by elucidating specific wastewater parameters which influence the prevalence and diversity of MDRO and antibiotic resistance genes. This will lead to development of optimal wastewater based models to accurately estimate the prevalence of MDRO, and ultimately inform targeted, population-specific strategies to mitigate multidrug resistance.

PI_NAMEs: ANNAVAJHALA, MEDINI K (contact)

PROGRAM_OFFICER_NAME: HUNTLEY, CLAYTON C

PROJECT_TERMS: Affect;Antibiotic Resistance;Antibiotic-resistant organism;Antibiotics;Antimicrobial Resistance;bacterial resistance;Biological Models;Biomedical Engineering;Bioreactors;carbapenem resistant Enterobacterales;Carbapenems;Cephalosporin Resistance;Cephalosporins;Chromatin;Circulation;Clinical;Clinical Data;clinically relevant;cohort;Collection;Communities;cost;cost effective;Data;data acquisition;Death Rate;Decision Making;design;Detection;Development;Disease Outbreaks;Early Diagnosis;epidemiological model;experimental study;Future;Gene Exchanges;gene interaction;Genetic;Genotype;Growth;Guidelines;gut colonization;Health Care Costs;high risk;Horizontal Gene Transfer;Hospitalization;Hospitals;improved;Individual;Infection;Link;Literature;Lung infections;mathematical model;Medical center;Metagenomics;Methods;Modeling;molecular marker;mortality;Multi-Drug Resistance;multi-drug resistant pathogen;Multiple Bacterial Drug Resistance;Neighborhoods;Non-linear Models;Nosocomial pneumonia;novel;Outcome;pathogen;pathogenic bacteria;pathogenic virus;Patient Isolation;patient population;Patients;Pattern;Phylogenetic Analysis;Plants;Population;Population Heterogeneity;Population Surveillance;Predisposition;pressure;Prevalence;prevent;primary outcome;Public Health;Reporting;Research;research clinical testing;residence;Resistance;resistance allele;resistance gene;resistance mechanism;Risk;Risk Assessment;Sampling;Series;sociodemographics;Stream;Surveillance Modeling;Techniques;Temperature;Testing;Time;tool;transmission process;trend;viral outbreak;wastewater epidemiology;wastewater samples;wastewater sampling;wastewater surveillance;wastewater testing

PROJECT_TITLE: Operationalizing wastewater-based surveillance of multidrug-resistant bacteria


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Digestive Diseases;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: DALLAS

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: PROJECT NARRATIVE With multi-drug resistance and a high recurrence rate, Clostridioides difficile (C. diff.) infection severely threatens human life and burdens health-care systems both in the United States and worldwide. As potent RNA polymerase (RNAP) inhibitors are front-line treatments for infectious diseases, this pioneering work will investigate the structure, function, and regulation of the C. diff. transcriptional machinery. The results generated will provide new knowledge needed to discover new drugs targeting C. diff. RNAP and understand their mechanisms of action, thereby improving antibiotic treatments for this emerging public health threat.

PI_NAMEs: CAO, XINYUN  (contact)

PROGRAM_OFFICER_NAME: RANALLO, RYAN

PROJECT_TERMS: Advisory Committees;Alkaline Phosphatase;Antibiotic Resistance;Antibiotic Therapy;Antibiotics;antimicrobial;aptamer;Area;Award;bacterial resistance;Bacterial RNA;base;Behavior;Binding;Biochemical;Biochemistry;Bioinformatics;Biological Assay;Biophysics;Broccoli - dietary;career;ChIP-seq;Clostridium difficile;Collaborations;combat;Communication;Complex;Cryoelectron Microscopy;Data Set;design;Development;Dissection;DNA;DNA-Directed RNA Polymerase;Docking;Drug Targeting;Educational process of instructing;Elongation Factor;Environmental Risk Factor;Enzymes;Escherichia coli;Exhibits;experimental study;Flagella;follow-up;Future;Gene Expression;Gene Expression Profile;Gene Expression Profiling;Generations;Genetic;genetic information;Genetic Transcription;genome-wide;Genomics;Goals;Growth;healthcare burden;Healthcare Systems;high throughput screening;host microbiome;Human;improved;In Vitro;in vivo;Incidence;Infection;infectious disease treatment;inhibitor;insight;Investigation;Kinetics;Knowledge;Leadership;Life;Maps;Mentors;Molecular;Molecular Conformation;Multi-Drug Resistance;Mus;mutant;N-terminal;new therapeutic target;non-prion;novel;Operon;Organism;paralogous gene;pathogen;pathogenic bacteria;Phase;Physiology;Play;Postdoctoral Fellow;prion-like;Prions;promoter;Promoter Regions;Protein Subunits;Proteins;Public Health;Recombinants;Recurrence;Regulation;Reporter;Research;Research Training;Resistance;Resources;response;rho;Ribosomal RNA;RNA;RNA Polymerase Inhibitor;Role;skills;Specificity;Structure;System;Techniques;termination factor;Testing;Texas;transcription factor;Transcription Initiation;Transcription Process;transcription termination;Transcriptional Regulation;United States;Universities;virtual screening;Virulence;Wisconsin;Work

PROJECT_TITLE: Mechanistic Dissection and Antibiotic Discovery Targeting Clostridioides difficile RNA Polymerase

STUDY_SECTION_NAME: Microbiology and Infectious Diseases Advisory Committee[MID]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Coronaviruses;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: GAINESVILLE

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) co-opts cellular metabolism for viral propagation. This research proposal describes synergistic efforts to develop CRISPR- based tools for dissecting viral mechanisms of host takeover and identifies RNA repair mechanisms that support SARS-CoV-2 replication. Collectively, the work proposed here will provide RNA editing tools with broad implications for science and medicine and generate new insights into RNA repair in human cells.

PI_NAMEs: NEMUDRYI, ARTEM ALEKSANDROVICH (contact)

PROGRAM_OFFICER_NAME: PLIMACK, MARY KATHERINE BRADFORD

PROJECT_TERMS: 2019-nCoV;Achievement;Acute;base;base editing;BCAR1 gene;Bioinformatics;Biological;Biological Assay;biosafety level 3 facility;Biotechnology;career;Cell Line;Cells;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Competence;Complex;Complex Mixtures;Conflict (Psychology);Coronavirus;COVID-19 detection;CRISPR/Cas technology;Data;deep sequencing;Defect;design;Detection;Diagnostic;DNA;DNA Repair;Epigenetic Process;Evolution;fitness;Foundations;Gene Expression Regulation;gene-editing approach;Genes;Genetic;Genome;genome integrity;genomic RNA;Goals;Guide RNA;Human;Impairment;improved;In Vitro;insight;Interferons;knock-down;Laboratories;Lesion;Ligase;Ligation;Maps;Mass Spectrum Analysis;Measures;Mediating;Medicine;Mentors;Messenger RNA;Metabolism;Methods;Modification;Molecular;Molecular Profiling;mutant;Mutation;Nature;nuclease;Outcome;overexpression;Pattern;Phase;Phenotype;Play;Positioning Attribute;Process;Proteins;Publishing;recruit;repaired;Research;Research Proposals;respiratory;response;Ribonucleases;RNA;RNA Biochemistry;RNA Editing;RNA Ligase (ATP);RNA metabolism;RNA Sequences;RNA Splicing;RNA Viruses;Role;Sampling;SARS-CoV-2 genome;Science;Shapes;Site-Directed Mutagenesis;Solid;Syndrome;System;Tail;Technology;Testing;tool;Training;transcriptome;transcriptome sequencing;Transfection;Transfer RNA;tRNA Ligase;Variant;Viral;Viral Proteins;viral RNA;Virus;Virus Replication;Work

PROJECT_TITLE: CRISPR-based editing of RNA and cellular mechanisms that govern RNA repair


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Clinical Research;Pain Research;Physical Injury - Accidents and Adverse Effects;Physical Rehabilitation;Rehabilitation;Women's Health Research

ORG_DEPT: ORTHOPEDICS

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE  Achilles tendinopathy is a painful condition that does not fully resolve in 20-60% of patients following conservative treatment. In this study, we will determine rehabilitation loading profiles and ultrasound imaging biomarkers that explain tendon healing and functional outcomes in patients. We will also measure circulating levels of sex hormones to determine how variations in sex hormones impact tendon healing and outcomes.

PI_NAMEs: BAXTER, JOSH  (contact)

PROGRAM_OFFICER_NAME: PINTUCCI, GIUSEPPE

PROJECT_TERMS: achilles tendon;Acute;Affect;Biomechanics;Chronic;Clinic;Clinical;clinical care;Clinical Research;Estrogens;Exercise;exercise rehabilitation;experience;functional outcomes;Goals;Gonadal Steroid Hormones;Guidelines;healing;Health;Heel;hormonal contraception;Image;imaging biomarker;improved;innovation;Measures;Monitor;Muscle;Outcome;Pain;pain outcome;Pathologic;Pathology;patient subsets;Patient-Focused Outcomes;Patients;Pattern;pill;Progesterone;Property;Protocols documentation;Recommendation;Recovery;reduce symptoms;Rehabilitation therapy;remote monitoring;Reporting;sex;Stress;Structure;Symptoms;Techniques;Telemedicine;Tendinopathy;Tendon Injuries;Tendon structure;Time;Ultrasonography;ultrasound;Variant;Visit

PROJECT_TITLE: Tendon loading profiles that promote healing in Achilles tendinopathy


ADMINISTERING_IC: NS

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Genetics;Human Genome;Neurosciences;Physical Injury - Accidents and Adverse Effects;Prevention;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: CLEVELAND

ORG_DEPT: GENETICS

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

PHR: PROJECT NARRATIVE Traumatic brain injury (TBI) is a leading cause of neurological disability, however the pathological mechanisms initiated by primary physical injury that lead to progressive cognitive and motor impairment are not well defined. This proposal will leverage stem cell biology and genomics techniques in order to understand how mechanotransduction by oligodendrocytes contributes to myelin pathology after TBI. The results of this proposal will contribute to the development of novel therapeutics aimed at enhancing white matter integrity after TBI.

PI_NAMEs: COHN, ERIN FRANCES (contact)

PROGRAM_OFFICER_NAME: AWWAD, HIBAH OMAR

PROJECT_TERMS: Action Potentials;Affect;American;Atrophic;Axon;Binding;Binding Proteins;Binding Sites;Biochemical;biological adaptation to stress;Biology;brain tissue;Cell Differentiation process;Cell Line;Cell Nucleus;Cell Physiology;Cells;cellular development;Central Nervous System;Cessation of life;Chemicals;ChIP-seq;Chronic;Clustered Regularly Interspaced Short Palindromic Repeats;Cognitive;Complex;Coupling;Cues;Cytoplasm;Data;Demyelinations;Development;Diagnosis;Disease;disease model;Dominant Genes;Enhancers;Environment;extracellular;fluid percussion injury;Functional disorder;Gene Expression;Genes;Genetic;Genetic Transcription;genome-wide;Genomics;Health;Hyperactivity;Immunohistochemistry;Impaired cognition;Impairment;In Vitro;in vivo;in vivo Model;Injury;insight;Interruption;knock-down;Knock-out;LATS1 gene;Ligands;Long term disability;Maintenance;mechanical force;mechanical stimulus;Mechanics;mechanotransduction;Mediating;Mediator;Molecular;Motor;motor disorder;motor impairment;Myelin;Nerve Degeneration;Nervous System Disorder;Neurodegenerative Disorders;Neuroglia;Neurologic;Neurological disability;Neurons;neuroprotection;Neurosciences Research;neurotransmission;notch protein;novel therapeutics;Nuclear;oligodendrocyte lineage;oligodendrocyte progenitor;Oligodendroglia;organ growth;organ regeneration;Pathologic;Pathology;Pathway interactions;pharmacologic;Phosphorylation;Phosphotransferases;Play;Population;preservation;prevent;Prevention;Process;progenitor;programs;Proliferating;promoter;protein expression;Protein Microchips;Proteins;receptor;Reporting;response;Role;Secondary Prevention;shear stress;Signal Pathway;Signal Transduction;Signal Transduction Pathway;small molecule inhibitor;stem cell biology;stem cell differentiation;stem cell function;stem cell proliferation;stem cells;Techniques;Technology;Therapeutic;tool;Transcription Coactivator;transcription factor;Transcriptional Regulation;transcriptome sequencing;Trauma;Traumatic Brain Injury;United States;white matter

PROJECT_TITLE: Pathological Mechanotransduction by Oligodendrocytes After Traumatic Brain Injury


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Digestive Diseases;Neurosciences;Opioid Misuse and Addiction;Opioids;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Substance Misuse

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

ORG_STATE: MO

PHR: Public Health Relevance Statement Use of opioids during pregnancy can result in a diagnosis of neonatal opioid withdrawal syndrome. These children can experience long hospital stays and have difficulty eating. Our fundamental goal is to understand how opioids affects the brain pathways essential to swallow, and to develop a platform in which new therapies can be tested.

PI_NAMEs: PITTS, TERESA G (contact)

PROGRAM_OFFICER_NAME: GUMINA, DIANE LAURA

PROJECT_TERMS: Acute;Affect;Algorithms;Anatomy;Animals;Area;Birth;brain pathway;Brain Stem;Breathing;Breeding;Calcium;Cell Nucleus;Cells;central pattern generator;Cervical;Child;Classification;Clinical;cohort;Color;Confocal Microscopy;Core Facility;Data;Data Collection;Deglutition;Deglutition Disorders;design;Development;Diagnosis;Dissection;Dorsal;Eating;Ensure;Esophagus motility;experience;experimental study;Exposure to;feeding;Female;fetal opioid exposure;Germ Lines;Goals;hindbrain;Histologic;histological image;Histological Techniques;Human Milk;Hypoglossal nerve structure;Image;Immunohistochemistry;indexing;Infant;Injections;insight;interest;Label;Laboratories;Length of Stay;Location;machine vision;Maps;Medial;Mediating;Methadone;Methods;Modeling;Motor;Motor Neurons;Motor output;mouse model;Mus;Neonatal Abstinence Syndrome;neonate;Nerve;neural circuit;neural patterning;Neuromodulator;Neurons;new therapeutic target;novel;novel therapeutics;nucleus ambiguus;Nucleus solitarius;Opioid;opioid exposure;opioid use in pregnancy;opioid withdrawal;Optics;Patient Care;Pattern;Pharyngeal structure;Phenotype;Population;postnatal period;prenatal exposure;Preparation;preservation;Process;public health relevance;pup;Reflex action;Regulation;Research Personnel;respiratory;response;Reticular Formation;Rodent;Saline;screening;Sensory;Somatostatin;Stimulus;Structure of phrenic nerve;subcutaneous;suckling;Techniques;Technology;Testing;tissue fixing;Tissues;Translations;Ventral Roots;Visualization;Withdrawal;Work

PROJECT_TITLE: Delinating Impacts of Gestational Opioid Exposure on Central Swallow Networks

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: Los Angeles

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

ORG_STATE: CA

PHR: Title: Brain cPLA2 as a mechanism for neuroinflammation in AD/ADRD with and without APOEε4 – Diversity Supplement In this supplement application, Cristelle Hugo will test the role of cPLA2 activation on cellular senescence in induced pluripotent stem cell (iPSC)-derived astrocytes carrying the APOEε4 allele, as well as in a set of patient-derived iPSCs. To identify whether cPLA2 activation AD status and APOE genotype, Cristelle Hugo will also study cPLA2 activation in the context of cellular senescence using a set of patient-derived astrocytes. This research project adds a new angle to the parent grant, with the potential to implicate cPLA2 activation in cellular senescence, an important component of aging and aging-related diseases like AD.

PI_NAMEs: ARVANITAKIS, ZOE ;YASSINE, HUSSEIN N (contact)

PROGRAM_OFFICER_NAME: DIBATTISTA, AMANDA

PROJECT_TERMS: Acceleration;Aging;aging related disease;Alleles;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease patient;Alzheimer's disease related dementia;Alzheimer's disease risk;Amyloid beta-Protein;Apolipoprotein E;apolipoprotein E-4;astrocyte progenitor;Astrocytes;Autopsy;Blood Vessels;Brain;brain cell;brain tissue;Calcium;Cell Aging;Cell Line;cell type;Cells;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Cognitive;Cohort Studies;Data;Dementia;Development;Disease;Disease Progression;Eicosanoids;Encephalitis;Fatty Acids;Freezing;Gene Expression;genetic risk factor;Genotype;Human;Immunofluorescence Immunologic;Impaired cognition;improved;Individual;induced pluripotent stem cell;Inflammation;inflammatory marker;Inflammatory Response;insight;interest;Knock-out;Late Onset Alzheimer Disease;Learning;Lipids;Lysosomes;Measures;Mediating;Memory;Mitochondria;Molecular;mouse model;Neuroglia;neuroinflammation;Neurons;neuropathology;novel;Outcome;parent grant;Pathologic;Pathology;Pathway interactions;patient derived induced pluripotent stem cells;Patients;Pattern;Persons;Phenotype;Phospholipase A2;phospholipase A2 inhibitor;Production;Public Health;Reactive Oxygen Species;religious order study;Research Project Grants;research study;response;Role;Sampling;senescence;Senile Plaques;Signal Pathway;Signal Transduction;Stains;stem cell population;Testing;therapeutic target;Work

PROJECT_TITLE: Brain cPLA2 as a mechanism for neuroinflammation in AD/ADRD with and without APOE4 Diversity Supplement


NIH_SPENDING_CATS: HIV/AIDS;Infectious Diseases;Malaria;Maternal Health;Maternal Morbidity and Mortality;Orphan Drug;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Rare Diseases;Vector-Borne Diseases;Women's Health Research

ORG_DEPT: PATHOLOGY

PHR: PROJECT NARRATIVE  The proposed studies aim to leverage a physiologically relevant non-human primate model of both HIV and malaria to identify key immune factors that drive poor maternal and fetal outcomes during infection in pregnancy. Establishing such immune mechanisms would create potential for considerable advances in the identification and pre-clinical testing of novel therapeutic strategies to restore health in women living with HIV who become infected with malaria during pregnancy. The proposed research is relevant to the mission of the NICHD as it will significantly contribute to the ultimate goal of reducing the substantial burden of malaria infection in vulnerable women living with HIV.

PI_NAMEs: MANUZAK, JENNIFER  (contact)

PROGRAM_OFFICER_NAME: MAJJI, SAI PRASANNA

PROJECT_TERMS: Address;Adherence;adverse outcome;African;Anemia;Animal Model;Biological;Biological Assay;Birth;Cessation of life;chemokine;Clinical;co-infection;Complex;Country;cytokine;Decidua;Decidua Basalis;Development;Disease;Endothelium;evidence base;fetal;Fetal Growth;fetal infection;Foundations;Frequencies;Functional disorder;Future;genetic signature;Geography;Goals;Health;high risk;HIV;Human;Immune;Immune response;Immune System Diseases;Immunologic Factors;Immunologics;Immunology;In Vitro;Incidence;Infant Mortality;Infection;infection risk;Inflammation;Inflammatory;innate immune function;innate immune mechanisms;innovation;Intervention;Knowledge;Low Birth Weight Infant;Lymphoid Cell;Macaca mulatta;Malaria;malaria infection;Maternal Health;Maternal Mortality;Mission;Modeling;Monitor;Morbidity - disease rate;mortality;National Institute of Child Health and Human Development;neutrophil;nonhuman primate;novel;novel therapeutic intervention;novel therapeutics;Outcome;Parasitemia;Parasites;Pathogenesis;Pathogenicity;Peripheral;Persons;Phenotype;Physiological;Placenta;Plasmodium;Plasmodium falciparum;Play;Population;preclinical study;Preclinical Testing;Pregnancy;Pregnancy Outcome;pregnant;Pregnant Women;Premature Birth;Prevention strategy;Production;Public Health;Publishing;Reporting;Research;Resources;Risk;Role;single-cell RNA sequencing;SIV;Spontaneous abortion;stillbirth;success;Testing;therapy design;therapy development;Tissues;transmission process;Validation;Viremia;Vulnerable Populations;Woman;Women's mortality;Work

PROJECT_TITLE: Mechanisms of Innate Immune Dysfunction in Siv/Malaria Co-infection in Pregnancy

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


ORG_DEPT: BIOMEDICAL ENGINEERING

PHR: This administrative supplement application is related to parent award U41 NS129514 “HORNET OpenNerve Platform” which aims to develop and disseminate an open-architecture and open-source implantable system for autonomic nerve stimulation and recording system to support clinical research for bioelectronic medicine applications. The objective here is to perform short- and long-term validation of the OpenNerve Platform functionality in large animals for closed-loop sacral nerve stimulation and for treatment of chronic constipation. Studies will include the implanted OpenNerve Platform components: (1) implantable pulse generator, (2) implantable leads for nerve stimulation; (3) implantable leads for recording muscle activity (4) implantable leads for strain sensing, and (5) implantable leads for pH and Acetylcholine sensing.

PI_NAMEs: HITTI, RAJA ;MENG, ELLIS  (contact);PIKOV, VICTOR

PROGRAM_OFFICER_NAME: HUDAK, ERIC MICHAEL

PROJECT_TERMS: Acetylcholine;Acute;Address;Administrative Supplement;Affect;American;Animals;Architecture;autonomic nerve;Autonomic nervous system;bioelectronics;Biological Markers;Chemicals;Childhood;Chronic;chronic pain;chronic pain patient;Clinical;Clinical Research;Collaborations;Colon;Colorectal;commercialization;Computer software;Constipation;Custom;design;Detection;Development;Disease;Distal;Elderly;Electrodes;Electromyography;experimental study;Family suidae;flexibility;High Prevalence;Histology;Human;Implant;implantation;Implantation procedure;implanted sensor;ineffective therapies;interest;Intestines;Lead;Manometry;manufacture;Measures;Medicine;Modeling;Monitor;Motility;Movement;multidisciplinary;Muscle;Nerve;neuroregulation;novel;open source;Operative Surgical Procedures;Opioid;Outcome;parent project;patient population;Patients;Penetration;Performance;Persons;Pharmacologic Substance;Physiologic Monitoring;Physiologic pulse;Population;porcine model;programs;Recovery;Research Personnel;Sacral nerve;Safety;sample fixation;Sense Organs;sensor;Silicones;Spinal;Spinal cord injury;Spinal cord injury patients;Stretching;Surgeon;System;Technology;Testing;therapeutic effectiveness;Time;translation to humans;United States National Institutes of Health;Validation;validation studies

PROJECT_TITLE: OpenNerve Platform for Chronic Constipation.


PHR: This administrative supplement application is related to parent award U41 NS129514 “HORNET OpenNerve Platform” which aims to develop and disseminate an open-architecture and open-source implantable system for autonomic nerve stimulation and recording system to support clinical research for bioelectronic medicine applications. The objective here is to perform short- and long-term validation of the OpenNerve Platform functionality in large animals for closed-loop cervical vagus nerve stimulation and glossopharyngeal nerve stimulation for treatment of stroke-induced dysphagia and aspiration pneumonia. Studies will include the implanted OpenNerve Platform components: (1) implantable pulse generator, (2) implantable leads for nerve stimulation; and (3) implantable leads for recording muscle activity.

PI_NAMEs: HITTI, RAJA ;MENG, ELLIS  (contact);PIKOV, VICTOR ;TAKAHASHI, KAZUTAKA

PROJECT_TERMS: Acute;acute stroke;Address;Administrative Supplement;Agonist;Algorithms;Animals;Architecture;aspirate;Aspiration Pneumonia;autonomic nerve;Autonomic nervous system;Axon;bioelectronics;Bolus Infusion;Capsaicin;Cervical;Chronic;chronic stroke;Clinical;Clinical Research;clinical translation;Communities;Computer software;Custom;Deglutition;Deglutition Disorders;Detection;Development;Diagnosis;Dysphasia;Economic Burden;electric impedance;Electric Stimulation;Electromyography;Esthesia;Evaluation;Exhibits;experience;first-in-human;Food;Functional disorder;Glossopharyngeal nerve structure;Hematoxylin and Eosin Staining Method;Hypoxia;Implant;implantation;interest;Larynx;Lead;Measures;Mechanical Stimulation;Mechanics;Medicine;meter;Morbidity - disease rate;mortality;Muscle;Myelin;Nerve;neuroregulation;open source;Oral cavity;Oropharyngeal Dysphagia;parent project;Pathology;Patients;Performance;Peristalsis;Pharyngeal structure;pharynx muscle;Phase;Physiologic pulse;post stroke;programs;Research;Research Personnel;Respiration;Safety;Sense Organs;Sheep;socioeconomics;Stains;stroke patient;stroke therapy;Structure of superior laryngeal nerve;System;Technology;Testing;Thinness;tissue injury;Tissues;Tolonium chloride;Translations;TRPV1 gene;United States National Institutes of Health;vagus nerve stimulation;Vagus nerve structure;Validation;Visual;Visualization

PROJECT_TITLE: OpenNerve Platform for Post-Stroke Dysphagia and Aspiration Pneumonia


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Cardiovascular;Nanotechnology;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: ARLINGTON

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF TEXAS ARLINGTON

PHR: NARRATIVE Peripheral arterial disease (PAD), an illness commonly found in the elderly and caused by arterial occlusion in the lower body, affects more than 200 million people worldwide and is associated with high rates of morbidity and mortality. To reduce these complications and improve the quality of life for PAD patients, our research aims to develop novel biodegradable nanoparticles to deliver therapeutic agents that specifically protect cells under ischemic stress conditions, facilitate the formation of blood vessels under hypoxia, and facilitate noninvasive multimodal imaging methods, such as fluorescent and photoacoustic imaging, to monitor the progress of this therapeutic intervention. The impact of our research is significant as these new nanoparticle platforms could be used to deliver any therapeutics locally, treat this disease effectively, and monitor the treatment noninvasively by imaging.

PI_NAMEs: MASON, RALPH P.;NGUYEN, KYTAI TRUONG (contact);YAN, SU

PROGRAM_OFFICER_NAME: DANTHI, NARASIMHAN

PROJECT_TERMS: Acute;Affect;Aftercare;Alternative Therapies;angiogenesis;Aniline;Animal Model;animal model selection;antibody conjugate;Apoptosis;Arteries;artery occlusion;Binding;Biocompatible Materials;Biodistribution;biomaterial compatibility;Blood coagulation;Blood flow;Blood Glucose;blood perfusion;blood vessel development;Blood Vessels;CD34 gene;Cell Survival;Cells;Cholesterol;Chronic;Collateral Circulation;combat;common treatment;Complementary DNA;Cytoprotection;Data;Death Rate;Detection;Development;Diarrhea;Disease;effective therapy;effectiveness evaluation;elastomeric;Elastomers;Elderly;endothelial stem cell;Erythropoietin Receptor;Evaluation;fabrication;femoral artery;fluorescence imaging;gene therapy;Goals;Growth Factor;Headache;Hemorrhage;Hypertension;Hypoxia;imaging modality;imaging properties;Impairment;improved;In Situ;In Vitro;in vivo;in vivo evaluation;Individual;Induction of Apoptosis;Inflammation;innovation;Intervention;Intramuscular;Ischemia;Leg;Ligation;limb ischemia;limb loss;Location;Lower Extremity;Mediating;Modality;Monitor;Morbidity - disease rate;mortality;mouse model;Multimodal Imaging;Names;nanoparticle;Nanotechnology;non-invasive imaging;novel;novel therapeutics;Obstruction;Operative Surgical Procedures;Pain in lower limb;Patients;Peripheral;Peripheral arterial disease;Persons;Pharmaceutical Preparations;Pharmacotherapy;photoacoustic imaging;Polymers;Predisposition;prevent;Property;Quality of life;Reagent;recruit;reduce symptoms;Research;Research Project Grants;Research Support;revascularization surgery;Role;side effect;Site;Stem Cell Mobilization;stem cells;Stress;Structure;success;Therapeutic;Therapeutic Agents;therapeutic angiogenesis;Therapeutic Effect;therapeutic effectiveness;Therapeutic Intervention;therapeutically effective;Tissue Engineering;Tissues;tool;Treatment Efficacy;United States;Vascular Diseases;Work

PROJECT_TITLE: Novel nanoparticles to stimulate therapeutic angiogenesis in peripheral arterial disease

STUDY_SECTION: IPCA

STUDY_SECTION_NAME: Imaging Probes and Contrast Agents Study Section[IPCA]


ORG_CITY: WASHINGTON

ORG_NAME: U.S. DEPT/VETS AFFAIRS MEDICAL CENTER

ORG_STATE: DC

PHR: While the majority of VHA enrollees have their own insurance, VA research and operation depend mostly on data within the VA to assess opioid use and evaluate policy. Meanwhile, Veterans who are dual users of the VA and community care are at higher risks of opioid use and misuse. This study will leverage several non-VA data sources along with VA data to study the opioid use and misuse in dual users vs the mono users, with the goal of improving care coordination and reduce opioid misuse.

PI_NAMEs: KUPERSMITH, JOEL ;ZENG, QING  (contact)

PROJECT_TERMS: addiction;Address;Administrator;Area;Benzodiazepines;care coordination;care fragmentation;Caring;chronic pain;Chronic pain syndrome;Clinical;Communication;Communities;Community Health;Community Healthcare;Complex Analysis;complex data;Data;Data Analyses;Data Sources;Databases;deep learning;Diagnosis;District of Columbia;Dose;Electronic Health Record;Electronics;Evaluation;Focus Groups;Goals;Guidelines;Health;Health Insurance;Health Personnel;Healthcare;Healthcare Systems;high risk;improved;informal caregiver;Information Systems;Injury;Insurance;Interview;Link;Maryland;Medicare;Methods;Mid-Atlantic Region;misuse of prescription only drugs;Musculoskeletal;National Health Interview Survey;Natural Language Processing;non-opioid analgesic;novel;operation;Opioid;opioid abuse;opioid epidemic;opioid misuse;opioid overdose;opioid use;opioid use disorder;Pain;Pain management;patient oriented;Patients;Policies;Policy Maker;prescription monitoring program;prescription opioid;prescription opioid misuse;Prevalence;Privatization;programs;Provider;psychiatric comorbidity;Recommendation;Reporting;Research;Risk Management;Safety;Statistical Methods;Stratification;suicidal risk;System;tool;Toxicant exposure;United States Centers for Medicare and Medicaid Services;United States Department of Veterans Affairs;Veterans;Veterans Health Administration;War;Woman;wound

PROJECT_TITLE: Assessing and Reducing Opioid Misuse Among Veterans in VA and Non-VA Systems: Coordination of Fragmented Care

STUDY_SECTION_NAME: HSR-5 Health Care System Organization and Delivery and Women's Health[HSR5]


NIH_SPENDING_CATS: Cancer;Clinical Research

ORG_CITY: BALTIMORE

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROPOSAL NARRATIVE We have found that neutrophil extracellular traps (NETs) activated during lung inflammation can trigger the awakening of dormant cancer cells that have spread to other organs, causing them to start proliferating again. This is a new concept for how an external factor, inflammation via NETs, promotes metastatic recurrence. Through three specific aims, we will determine exactly how NETs drive dormant tumor cells to proliferate, how NETs activate macrophages to generate an inflammatory microenvironment, and how best to target NETs to prevent metastasis.

PI_NAMEs: EGEBLAD, MIKALA  (contact)

PROGRAM_OFFICER_NAME: WATSON, JOANNA M

PROJECT_TERMS: Antibodies;Automobile Driving;Basement membrane;Biology;Blocking Antibodies;cancer cell;Cell Physiology;chemotherapy;Combined Modality Therapy;Data;Development;Diagnosis;Epitopes;extracellular;Extracellular Space;FDA approved;Feedback;Genomic DNA;Goals;Growth;HMGB1 gene;Human;Infection;Inflammation;Inflammatory;insight;Integrin alpha3beta1;Integrins;Interleukin-1 beta;Intervention;intervention effect;intravital imaging;Knowledge;Laminin;Lipopolysaccharides;Macrophage;Macrophage Activation;Malignant Breast Neoplasm;Malignant Neoplasms;Mass Spectrum Analysis;Mediating;Membrane Proteins;Metastatic breast cancer;metastatic process;Metastatic/Recurrent;mortality;mouse model;Mus;Mutagenesis;Neoplasm Metastasis;neoplastic cell;neutrophil;Normal Cell;novel;novel therapeutic intervention;Organ;Pathway interactions;Peptide Hydrolases;Pharmaceutical Preparations;Pre-Clinical Model;prevent;Primary Neoplasm;Process;Proliferating;Proteins;Pulmonary Inflammation;Rattus;receptor;Reporting;Research;response;Signal Transduction;Site;systemic inflammatory response;Testing;Tissues;Tobacco smoke;tobacco smoke exposure;tumor;tumor microenvironment;Woman

PROJECT_TITLE: Identifying the pro-metastatic mechanisms of neutrophil extracellular traps

STUDY_SECTION: TME

STUDY_SECTION_NAME: Tumor Microenvironment Study Section[TME]


ORG_CITY: INDIANAPOLIS

ORG_NAME: RLR VA MEDICAL CENTER

ORG_STATE: IN

PHR: Ensuring that colonoscopy is performed well is necessary for optimizing prevention of colorectal cancer (CRC). One of the most important ways of measuring the quality of colonoscopy is to see how often CRC occurs following an initial colonoscopy that does not show CRC, an entity known as “post-colonoscopy CRC” (PCCRC). We plan to: 1) measure how often PCCRCs occur in Veterans; 2) compare Veterans who have PCCRC with those who have an initially detected CRC for cancer stage, surgical complications, and survival; 3) identify factors associated with PCCRC, some of which may lend themselves to interventions that improve how colonoscopy is performed and how well follow-up occurs, measures that will make sure Veterans are receiving colonoscopy and follow-up of the highest quality.

PI_NAMEs: IMPERIALE, THOMAS F. (contact);KAHI, CHARLES JOSEPH

PROJECT_TERMS: Adherence;Affect;Age;aged;attributable risk;cancer diagnosis;cancer site;Case/Control Studies;Characteristics;Cohort Studies;Colonoscopy;Colorectal;Colorectal Cancer;colorectal cancer prevention;colorectal cancer risk;colorectal cancer screening;comorbidity;computer infrastructure;Cross-Sectional Studies;data repository;data warehouse;Databases;Detection;Development;Diagnosis;Diagnostic;Diagnostic Errors;Disease;Educational Status;effectiveness evaluation;Electronics;Ensure;Etiology;Excision;experience;Feces;follow-up;German population;Germany;Goals;Greenland;Guidelines;Healthcare;Healthcare Systems;Hospitalization;improved;Incidence;indexing;informatics infrastructure;Institution;Intervention;Knowledge;Lesion;Literature;Logistic Regressions;Malignant Neoplasms;Manuals;Measures;Medical Records;medical specialties;Methods;Modality;mortality;Multivariate Analysis;neoplasm registry;Neoplasms;Nested Case-Control Study;Occult blood screen;Odds Ratio;Operative Surgical Procedures;Outcome;Patient-Focused Outcomes;Patients;Performance;Polypectomy;polyposis;Polyps;Population;population based;Population Study;Postoperative Period;Preparation;Prevalence;primary outcome;Procedures;programs;Publishing;Recommendation;Research;Research Design;Resected;Retrospective cohort study;Risk;Risk Factors;Role;rurality;screening;secondary outcome;sex;Sigmoidoscopy;success;Surgical complication;survival outcome;System;Testing;Time;Translating;Veterans;Veterans Health Administration;Vital Status;Withdrawal

PROJECT_TITLE: Prevalence, Risk Factors and Outcomes of Post-colonoscopy Colorectal Cancer in Veterans


NIH_SPENDING_CATS: Biotechnology;Cancer;Lung;Lung Cancer

ORG_CITY: ANN ARBOR

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative The goal of this proposal is to deliver an agent capable of blocking active EGFR dimerization independent of TKI resistant mutations. This approach of targeting selective disruption of active-EGFR dimerization is expected to be safe and effective.

PI_NAMEs: LAWRENCE, THEODORE S;NYATI, MUKESH K. (contact)

PROGRAM_OFFICER_NAME: FORRY, SUZANNE L

PROJECT_TERMS: Address;Advanced Development;Area;Binding;Biodistribution;Biological Availability;cancer cell;Cancer cell line;cancer imaging;Cancer Patient;cancer therapy;Cell Death;Cell Line;Cell Survival;Cells;chemotherapy;Chronic;Clinical;Clinical effectiveness;Clinical Research;clinically relevant;Data;design;Development;Diagnosis;Dimerization;Dose;Drug Exposure;Drug Kinetics;Effectiveness;efficacy evaluation;Epidermal Growth Factor Receptor;Exposure to;Frequencies;Future;Generations;Genes;Goals;Immunocompetent;improved outcome;In Vitro;in vivo;in vivo evaluation;inhibitor;inhibitor therapy;Knowledge;Luciferases;lung cancer cell;Lung Neoplasms;lung xenograft;Malignant neoplasm of lung;Methods;Modeling;Monitor;mouse model;Mus;mutant;Mutate;Mutation;neoplastic cell;Non-Small-Cell Lung Carcinoma;Normal Cell;novel;Null Lymphocytes;Oncogenic;Oral;Oral Administration;Organ;patient derived xenograft model;Patient-Focused Outcomes;Patients;Pattern;Pharmaceutical Preparations;Pharmacodynamics;pharmacokinetics and pharmacodynamics;Phosphotransferases;Plasma;Positron-Emission Tomography;pre-clinical;Probability;Progression-Free Survivals;protein expression;Protein Tyrosine Kinase;Proteins;receptor;receptor expression;Receptor Protein-Tyrosine Kinases;refractory cancer;Regimen;Research Design;Resistance;Resistance development;resistance mutation;response;Safety;Schedule;Series;small molecule;Specificity;Statistical Models;Study models;targeted agent;Therapeutic;therapy resistant;Tissues;Toxic effect;treatment effect;Treatment Efficacy;Treatment Protocols;treatment response;tumor;tumor progression;Tyrosine Kinase Inhibitor;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Development of a first-in-class mEGFR dimerization inhibitor

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 2 Study Section[MCT2]


ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: STANFORD

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE The effort to fully realize health equity across ethnicity, race, age, disability, and geography will be accelerated by the use of data that best measures and captures the health of all Americans and the contexts in which they receive their care. Minoritized populations, older populations, rural populations and persons with disabilities have been underrepresented in the real-world data used for studies of drug and device safety and efficacy and many datasets do not adequately measure domains necessary for health equity research. To address these challenges, we will evaluate the impact of race, ethnicity, geography and social deprivation on the delivery of guideline concordant care for COVID-19, using data from a diverse cohort of nearly eight million primary care patients from small independent clinics across the U.S.

PI_NAMEs: REHKOPF, DAVID H (contact)

PROGRAM_OFFICER_NAME: LEE, CHRISTINE

PROJECT_TITLE: Assessing the racial, ethnic, and geographic equitability of COVID-19 treatments in a primary care population


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Prevention

ORG_CITY: LOS ANGELES

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: RELEVANCE (See instructions): This proposal aims to study the in vivo roles of histone modifiers in cell specification and behavior in vertebrate neurodevelopment. The resulting data will provide greater mechanistic insight into how histone modifiers, especially lysine methyltransferases identified as autism-linked genes, establish the gene regulatory networks during development that define cell identities, and the brain circuits and pathways affected by their loss-of-function using behavior as a readout. This is of paramount importance, given the

PI_NAMEs: TORNINI, VALERIE ANGELA (contact)

PROGRAM_OFFICER_NAME: OREILLY, JULIA JIAQI

PROJECT_TERMS: Affect;autism spectrum disorder;Behavior;Behavioral;Behavioral Assay;behavioral phenotyping;behavioral response;Biological Assay;Brain;brain cell;Brain region;candidate identification;cell type;Cells;Characteristics;Child Health;Chromatin;Code;Communication;Computer Analysis;Data;Development;developmental disease;Dissection;Epigenetic Process;Etiology;Fingerprint;Gene Expression;gene function;gene regulatory network;Genes;Genetic;Histones;Human;Human Development;in vivo;insight;Instruction;Link;loss of function;Lysine;Methyltransferase;Methyltransferase Gene;MLL gene;Molecular;mutant;Mutation;neural;neurodevelopment;Neurodevelopmental Disorder;Neurons;novel;Pathway interactions;Personal Satisfaction;pharmacologic;Phenotype;Physiological;Play;programs;Resolution;risk variant;Role;screening;Severities;Shapes;Signal Pathway;social;Specific qualifier value;Symptoms;System;Testing;transcriptomics;Variant;Vertebrates;Zebrafish

PROJECT_TITLE: Functional analysis of histone modifier Autism Spectrum Disorders risk genes in vertebrate development


NIH_SPENDING_CATS: Aging;Cancer;Genetics;Hematology;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: BAR HARBOR

ORG_NAME: JACKSON LABORATORY

ORG_STATE: ME

PHR: PROJECT NARRATIVE / RELEVANCE TO PUBLIC HEALTH Aging is a complex process that drives increased cancer risk in tissues throughout the body, including the blood system. To understand why aged individuals have higher risk of developing blood cancers, there is a vital need to understand the mechanisms by which aging contributes to clonal expansion and transformation. This research is relevant to public health because it will provide mechanistic insights into effective therapeutic strategies to target clonal evolution, attenuate pathophysiology promoted by clonal expansion, and intercept malignant transformation.

PI_NAMEs: LEVINE, ROSS L;TROWBRIDGE, JENNIFER JEAN (contact)

PROGRAM_OFFICER_NAME: GUO, MAX

PROJECT_TERMS: Acute Myelocytic Leukemia;Age;age related;age-related disease;aged;Aging;aging population;aging process;aging related;Alleles;Attenuated;Biological;Blood;cancer initiation;cancer risk;Cell Compartmentation;Clonal Evolution;Clonal Expansion;Coculture Techniques;Complex;Data;Dependence;DNMT3a;Epigenetic Process;epigenetic regulation;fitness;Functional disorder;Goals;Hematologic Neoplasms;Hematopoiesis;Hematopoietic;Hematopoietic Neoplasms;Hematopoietic stem cells;Hematopoietic System;high risk;Human;human tissue;Incidence;Inflammation;Inflammatory;innovation;insight;Intercept;leukemia;leukemic transformation;Malignant - descriptor;Malignant Neoplasms;middle age;Molecular;mouse model;Mus;mutant;Mutation;novel;old mice;Phenotype;pressure;pro-aging;Process;Public Health;Research;Risk;Risk Factors;Role;Sampling;Signal Transduction;Somatic Mutation;stem cell expansion;System;Therapeutic Studies;therapeutically effective;Tissues

PROJECT_TITLE: Assessing the Interplay Between Inflammatory Signaling and Epigenetic Dysregulation in Age-associated Clonal Hematopoiesis and Leukemia Initiation