NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Climate-Related Exposures and Conditions;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Neurosciences;Pediatric;Prevention;Schizophrenia;Serious Mental Illness;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC

PHR: Project Narrative Millions of Americans suffer from deficits in reward processing and working memory in the context of psychiatric disorders, such as major depressive disorder, schizophrenia, and attention deficit hyperactivity disorder. Early life stress and exposure to air pollution increase the risk of developing these disorders and affect reward processing and memory. In this project, we will systematically investigate how early life stress and pollution impact key brain circuits and test ways to prevent their negative effects of stress on the brain.

PI_NAMEs: DRANOVSKY, ALEX ;HARRIS, ALEXANDER  (contact)

PROGRAM_OFFICER_NAME: HOLLANDER, JONATHAN

PROJECT_TERMS: Affect;Air;Air Pollution;American;Anatomy;Anhedonia;Animals;Attention deficit hyperactivity disorder;behavioral response;Brain;brain circuitry;Cognitive;cognitive function;cognitive process;Communication;Data;dentate gyrus;design;Diesel Exhaust;Diesel Fuels;Disease;Dissection;Dopamine;dopamine system;dopaminergic neuron;early life exposure;early life stress;Economically Deprived Population;Environment;Environmental Exposure;Environmental Monitoring;Environmental Pollution;experience;experimental study;Exposure to;Hippocampus;Human;Impairment;in vivo;Injury;Intervention;Knowledge;Learning;Life;Major Depressive Disorder;Maps;Measures;Memory;Memory impairment;Mental Depression;Mental disorders;Motivation;Mus;neighborhood disadvantage;neural;Neurons;neurotoxic;optogenetics;Outcome;particle;Pathology;Patients;Perinatal;Perinatal Exposure;Physiology;Policies;pollutant;Pollution;prenatal;Prevalence;prevent;Property;reward processing;Rewards;Risk;Schizophrenia;Short-Term Memory;socioeconomic disadvantage;stem cells;Stress;Structure;Symptoms;System;Testing;Toxic Environmental Substances;treatment strategy;Ventral Tegmental Area;Work

PROJECT_TITLE: Motivational and Cognitive Circuit Mechanisms of Environmental Toxin-Induced Risk for Psychiatric Disorders.


ADMINISTERING_IC: DC

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Dental, Oral, and Craniofacial Disease;Neurosciences;Nutrition;Prevention

ORG_CITY: TALLAHASSEE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PSYCHOLOGY

ORG_FIPS: US

ORG_NAME: FLORIDA STATE UNIVERSITY

ORG_STATE: FL

PHR: PROJECT NARRATIVE Very little is known about how the sensory information relayed by the peripheral gustatory system influences the choice of foods or the way they are eaten, despite the critical relationship between taste and eating and how this knowledge could dramatically improve the design of nutrition guidelines. In particular, we do not know how the individual nerves, which innervate taste buds of the tongue and provide gustatory information as food enters the alimentary tract, affect ingestive behavior or how the form or energy density of the foods consumed may interact with these processes. We will use a behavioral approach to identify what role individual lingual gustatory nerves play in food choice and meal patterns to determine if these nerves provide information that aids in the control of food intake and discern if food characteristics like form or energy density may interact with this function to improve our understanding of biological factors influencing eating behavior and potentially increase the practicability of nutrition guidelines.

PI_NAMEs: CAWTHON, CAROLINA R. (contact)

PROGRAM_OFFICER_NAME: SULLIVAN, SUSAN L

PROJECT_TERMS: Acute;Adoption;Affect;Anterior;Behavior;Behavioral;Biological Factors;burden of chronic illness;Carbohydrates;Characteristics;chorda tympani;Chronic;Corn Oil;Custom;Data;Denervation;density;design;Diet;dietary;dietary guidelines;Dietary intake;Dietary Intervention;Discrimination;Disparity;Eating;Eating Behavior;energy density;Fatty acid glycerol esters;Feeding behaviors;Female;Food;food consumption;Food Selections;Future;Gastrointestinal tract structure;Glossopharyngeal nerve structure;Guidelines;Health;healthcare burden;improved;Individual;Intake;Knowledge;Laboratories;Liquid substance;Macronutrients Nutrition;Maintenance;male;Monitor;Motor output;National Institute on Deafness and Other Communication Disorders;Nerve;nerve supply;nerve transection;neurotransmission;novel;Nutrient;nutrition;Nutritional;Oral cavity;Outcome;Pattern;Peripheral;Play;preference;Process;Production;programs;Public Health;Publications;Quality of life;Rattus;Recommendation;Reflex action;Regulation;Research;response;Rodent Model;Role;segregation;Sensory;sensory input;Services;sex;sham surgery;Signal Transduction;Smell Perception;Solid;Taste Buds;Taste Perception;taste system;Tongue

PROJECT_TITLE: The Contribution of Taste to Nutrient-Related Ingestive Behavior

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Digestive Diseases;Immunotherapy;Obesity;Orphan Drug;Pancreatic Cancer;Rare Diseases

ORG_CITY: KANSAS CITY

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: PROJECT NARRATIVE Pancreatic Ductal Adenocarcinoma (PDAC) is a notoriously difficult to treat disease, and is resistant to immunotherapy based therapeutic approaches. We’ve found that depletion of CXCL5 is sufficient to mount an immune response against PDAC and increase T cell infiltration. The current studies, will take advantage of a Plectin targeted adenovirus-based delivery system to suppress tumor derived CXCL5 and validate alterations in efficacy of checkpoint inhibition.

PI_NAMEs: VANSAUN, MICHAEL NATHAN (contact)

PROGRAM_OFFICER_NAME: CHRISTEN, JAYNE

PROJECT_TERMS: Acinar Cell;Adenoviruses;Adipose tissue;advanced disease;Age;anti-PD-1;anti-PD1 antibodies;anti-PD1 therapy;Binding;Biological;Biological Markers;Cancer Etiology;candidate marker;Capsid;CD8-Positive T-Lymphocytes;cell type;Cells;cellular transduction;Cessation of life;checkpoint inhibition;chemokine;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;CXCL5 gene;cytokine;Cytoplasm;Cytotoxic T-Lymphocytes;Data;design;Development;Disease;Dissociation;DNA cassette;Drug Delivery Systems;Drug Targeting;Endothelial Cells;Engineering;Epithelial Cells;Exocrine pancreatic insufficiency;experimental study;Fibroblasts;Flow Cytometry;Fluorescence;Future;Gene Expression Profile;Genetic;Genetic Engineering;Genetically Engineered Mouse;Growth;high resolution imaging;IL8RA gene;IL8RB gene;Immune;immune checkpoint blockade;Immune checkpoint inhibitor;Immune response;Immunity;immunogenic;immunogenicity;Immunosuppression;Immunotherapeutic agent;Immunotherapy;improved;In Vitro;in vivo;in vivo imaging system;Inflammation;inhibitor;interest;Interleukin-1 beta;Learning;Ligands;Lymphocytic Infiltrate;Malignant neoplasm of pancreas;Modeling;Molecular;Monitor;mouse model;Mus;Myelogenous;neoplastic cell;Obese Mice;Obesity;Outcome;pancreas development;pancreatic cancer cells;pancreatic cancer model;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;pancreatic ductal adenocarcinoma model;particle;Patient-Focused Outcomes;Peptides;pharmacologic;Phenotype;plectin;pre-clinical;Predisposition;Prognosis;protein expression;Proteins;Publishing;receptor;receptor expression;recruit;Reporter;Reporting;Research Personnel;Resistance;response;Risk Factors;RNA;serial imaging;side effect;small hairpin RNA;specific biomarkers;Specificity;standard of care;System;systemic inflammatory response;T cell infiltration;T-Lymphocyte;targeted biomarker;targeted treatment;Testing;Therapeutic;Therapeutic Studies;Tissues;TNF gene;tumor;tumor microenvironment;Tumor-Derived;tumorigenic;ultra high resolution;Viral

PROJECT_TITLE: Enhancing intratumoral T cell infiltration by deliver of shCXCL5 in a Plectin targeted AAV to improve checkpoint blockade efficacy

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-F (O1)]


ADMINISTERING_IC: AG

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Palliative Care

ORG_CITY: Aurora

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE There is a need to mentor junior clinical investigators with the research skills to improve care for persons living with Alzheimer's disease and related dementias (ADRD) and family care partners. As a geriatrician and ADRD researcher, Dr. Hillary Lum's research activities will enhance the science of engagement involving persons living with dementia and their care partners, and her mentorship activities will focus on enhancing the pipeline of ADRD investigators who progress to independent research careers that prioritize the needs of persons living with dementia and their care partners.

PI_NAMEs: LUM, HILLARY  (contact)

PROGRAM_OFFICER_NAME: FAZIO, ELENA

PROJECT_TERMS: Address;Advance Care Planning;Affect;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;career;Caring;Catalogs;Clinical Investigator;Collaborations;collaboratory;Colorado;Communication;Communities;community engaged research;Dementia;dementia care;design;Discipline;Doctor of Philosophy;Elderly;Ethics;evidence base;Family;Fellowship Program;Funding;Geriatrics;Goals;Grant;health information technology;Health system;Healthcare Systems;improved;Institution;Intervention;intervention refinement;Interview;investigator training;Lead;Leadership;Lived experience;Medical;member;Memory;Mentors;Mentorship;Methods;Mid-Career Clinical Scientist Award (K24);Midcareer Investigator Award in Patient-Oriented Research;mild cognitive impairment;multidisciplinary;National Center for Advancing Translational Sciences;Neurology;Nursing Faculty;online resource;Online Systems;Outcome;Outcome Measure;Palliative Care;Palliative Medicine;patient engagement;patient oriented;patient oriented research;patient portal;Patients;Persons;Physicians;Postdoctoral Fellow;Process;Productivity;programs;Publications;Questionnaires;Recommendation;Research;Research Activity;Research Methodology;Research Personnel;Resource Sharing;Role;Scholars Program;Science;skills;Structure;Surveys;Testing;therapy design;Time;tool;United States National Institutes of Health;Universities;Visit;web-based tool

PROJECT_TITLE: Mentoring Investigators in Dementia Research by Engaging with Persons with Alzheimer's Disease and Care Partners

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development for Clinicians/Health Professionals Study Section [AGCD-3]


ADMINISTERING_IC: LM

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative The book project links the notion of health equity to a philosophical theory of social justice that is more amenable to achieving greater equity in health than many prevalent theories of social justice. Using this theory of justice, known as “relational egalitarianism”, as a basis, it also provides guidance for how health equity should be understood, measured, and represented in the health sciences, policy, and education. The book is of public health relevance because it thus contributes to minimizing unjust health disparities, also known as health inequities.

PI_NAMEs: FOURIE, CARINA  (contact)

PROGRAM_OFFICER_NAME: YOON, SUNG SUG

PROJECT_TERMS: ableism;Address;Bioethics;Books;Centers for Disease Control and Prevention (U.S.);Conceptions;disability;Education;Equity;Ethics;Foundations;Gender;Goals;Health;Health Care Ethics;health disparity;health equity;health inequalities;Health Policy;Health Sciences;Healthcare;improved;individual responsibility;Inequality;innovation;Justice;Lead;Life;Link;Literature;marginalized population;Measures;Methodology;Persons;Philosophy;Policies;Politics;Public Health;public health relevance;public health research;Race;racism;Research;Secure;Sexism;social health determinants;Social Justice;Structural Racism;theories;web site;Work

PROJECT_TITLE: Securing Health Equity: Philosophical Foundations for Equality and Social Justice in Public Health and Health Care

STUDY_SECTION_NAME: Special Emphasis Panel[ZLM1 ZH-P (01)]


ORG_CITY: SAN DIEGO

ORG_NAME: SCINTILLON INSTITUTE FOR PHOTOBIOLOGY

ORG_STATE: CA

PHR: Project Narrative We propose to develop a novel methodology to enable monitoring of oxygen levels in live cells. The methodology will be based on a fluorescent protein fused to various naturally occurring oxygen-binding proteins; proposed biosensor will be amendable to targeting to different cellular compartments or tissues. The ability to image oxygen gradients with subcellular resolution will lead to transformative insights into oxygen sensing and cancer.

PI_NAMEs: CRACAN, VALENTIN  (contact)

PROGRAM_OFFICER_NAME: COUCH, JENNIFER A

PROJECT_TERMS: absorption;Address;Adenylate Cyclase;Aerobic;Affinity Chromatography;Atmosphere;Bacteria;Bilirubin;Binding;Binding Proteins;Biochemical;Biochemical Reaction;Biochemistry;Bioenergetics;Biological;Biosensor;Cancer cell line;Cell Culture System;Cell Differentiation process;Cell Line;Cell membrane;Cell Nucleus;Cell Physiology;Cell Respiration;Cells;Chimeric Proteins;chromophore;cofactor;Conventional (Clear Cell) Renal Cell Carcinoma;Coupled;Cyclic GMP;design;Development;Dyes;Eels;Electrodes;Energy harvesting;Energy Metabolism;Engineering;Escherichia coli;Eukaryotic Cell;Evaluation;Event;Fluorescence;Fluorescence Resonance Energy Transfer;Globin;Glucose;Heme;heme a;Hemeproteins;Hypoxia;Image;imaging approach;in vivo;insight;interest;Japanese;Knowledge;Life;Literature;Lower Organism;Malignant Neoplasms;Mammalian Cell;Measures;Metabolic;Metabolism;Methodology;Methods;Mitochondria;Molecular;Molecular Conformation;Monitor;novel;optical spectra;Organism;oxidation;Oxidation-Reduction;Oxidative Phosphorylation;Oxygen;Pathology;Permeability;peroxisome membrane;Phenotype;phosphoric diester hydrolase;Physiological;Physiology;Planet Earth;Play;Positioning Attribute;programs;Proteins;Reactive Oxygen Species;Recombinant Proteins;Renal Carcinoma;Renal Cell Carcinoma;Reporter;Reporting;Research Personnel;Resolution;Respiratory Chain;Role;scaffold;Scaffolding Protein;sensor;Shapes;Signal Transduction;Source;spatiotemporal;System;Technology;Tissue Sample;Tissues;Tumor Suppressor Proteins;Variant;VHL gene;Visualization;Work

PROJECT_TITLE: Deciphering the dichotomy of oxygen metabolism in renal cancer using a novel genetically encoded oxygen biosensor

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-1 (O2)]


NIH_SPENDING_CATS: Cachexia;Cancer;Digestive Diseases;Genetics;Liver Disease;Nutrition;Pancreatic Cancer;Prevention;Rare Diseases;Rehabilitation

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE Despite advances in detection and treatment of pancreatic cancer, there remains no clinically efficacious treat- ment for cachexia—the severe wasting syndrome that accompanies 80% of pancreatic cancer cases. The work in this proposal combines advanced epigenetic techniques with a novel mouse model for pancreatic cancer survivorship to study the molecular underpinnings of sustained metabolic deficits after cancer recovery. Expand- ing our understanding of the persistence of metabolic symptoms after cancer recovery will provide vast benefit to improving the quality of life for patients experiencing and surviving from pancreatic cancer.

PI_NAMEs: ARNESON-WISSINK, PAIGE C (contact)

PROGRAM_OFFICER_NAME: RADAEV, SERGEY

PROJECT_TERMS: Address;Affect;Anticachexia Agent;ATAC-seq;Binding;Biological Assay;Cachexia;Cancer Cachexia;Cancer Survivor;Cancer Survivorship;Cells;Circulation;Cleavage Under Targets and Release Using Nuclease;Clinical;Co-Immunoprecipitations;Data;Dependence;Detection;detection of nutrient;Diagnosis;DNA;DNA Binding;DNA Methylation;DNA Modification Methylases;Down-Regulation;efficacious treatment;Epigenetic Process;Esters;Event;experience;Fasting;fatty acid oxidation;Fatty Acids;Foundations;Functional impairment;Gene Expression;Gene Silencing;Genes;genomic locus;Genus Hippocampus;Goals;Hepatic;Hepatocyte;Impairment;implantation;improved;Inflammation;Inflammatory;inhibitor;innovation;Interleukin-6;Intervention;ketogenesis;ketogentic;Ketones;Knock-out;Knowledge;Link;Lipids;Liver;liver metabolism;Malignant neoplasm of pancreas;Malignant Neoplasms;Measures;Mediating;Metabolic;Metabolic dysfunction;Metabolic Pathway;Metabolism;Methylation;Mitochondria;Modeling;Modification;Molecular;mortality;mouse model;Mus;Muscle;muscle form;Muscular Atrophy;Mutation;novel;Nutrient availability;nutrition;Nutritional;Organ;overexpression;oxidation;pancreatic cancer model;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma model;Patients;Pattern;Positioning Attribute;pre-clinical;Preclinical Testing;prevent;Production;programs;Promoter Regions;Quality of life;Recovery;Regulation;Research;response;Role;Signal Transduction;Skeletal Muscle;STAT1 protein;Stat3 protein;Stimulus;Stress;Supplementation;survivorship;Symptoms;systemic inflammatory response;Techniques;Testing;Therapeutic;Therapeutic Intervention;timeline;Tissues;Training;Transcription Repressor;Transcriptional Regulation;Translations;tumor;Wasting Syndrome;Work

PROJECT_TITLE: Elucidating the role of hepatic ketogenesis in pancreatic cancer cachexia and recovery

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 RTRB-U (O1)]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Contraception/Reproduction;Depression;Mental Health;Mental Illness;Pediatric;Suicide;Women's Health Research

ORG_CITY: CHAPEL HILL

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative Suicide is the second leading cause of death among those ages 10-34 years and the risk of suicidal thoughts and behavior skyrockets during adolescence, especially among girls, yet there is no firm understanding of why this is so. In two separate prior projects, our team has revealed that 1) adolescent girls’ acute social stress responses predict suicidal thoughts and behavior, and 2) that specific characteristics of the menstrual cycle are associated with elevated risk of suicide among adult women. This proposed project integrates these research programs to better help understand why girls are at increased risk, when girls may be most at risk, and which girls are at highest risk for future suicidal thoughts and behaviors.

PI_NAMEs: EISENLOHR-MOUL, TORY ANNE;GIRDLER, SUSAN S. (contact);NOCK, MATTHEW K

PROGRAM_OFFICER_NAME: MURPHY, ERIC ROUSSEAU

PROJECT_TERMS: 12 year old;Accidents;Acute;Adolescence;Adolescent;Adult;Adult women;Affective;Age;aged;Anger;Anxiety;Award;Behavioral;biological adaptation to stress;Biological Assay;Biological Markers;boys;Cause of Death;Characteristics;Clinical;Country;Data;depressive symptoms;design;Development;Diagnosis;Diagnostic Procedure;diaries;Distal;experience;Feeling;Feeling suicidal;Female;Female Adolescents;follow-up;Funding;Future;Genomics;girls;high risk;hormone sensitivity;Hormones;Hydrocortisone;ideation;Individual Differences;innovation;Interruption;Laboratories;Link;Literature;Measures;Mediating;Mediator;Menarche;Menstrual cycle;Mental Depression;Mental disorders;Molecular;molecular marker;Mood Disorders;Moods;mortality;negative affect;Negative Valence;Neurosciences;Ovarian hormone;Participant;perimenstrual;Persons;Phase;Physiological;predicting response;Procedures;Process;programs;proliferative phase Menstrual cycle;prospective;psychological symptom;Psychopathology;recruit;Recurrence;Reporting;reproductive;reproductive hormone;Research;Research Domain Criteria;Research Personnel;response;Risk;Risk Behaviors;Risk Factors;Sampling;Science;Severities;Shapes;social;social adversity;social stress;Standardization;Stress;stress reactivity;stressor;suicidal adolescent;suicidal behavior;suicidal risk;Suicide;Suicide attempt;suicide rate;Surveys;System;Testing;theories;Time;United States National Institutes of Health;virtual;Visit;Work;Youth

PROJECT_TITLE: Adolescent Girls’ Risk for Suicide Across the Menstrual Cycle:  Examining Stress and Negative Valence Systems Longitudinally

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Colorectal Cancer;Digestive Diseases;Emerging Infectious Diseases;Genetics;Human Genome;Infectious Diseases;Microbiome;Prevention

ORG_CITY: NEW HAVEN

ORG_DEPT: CHEMISTRY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE: Select strains of bacteria in the human gut produce a small molecule genotoxin known as colibactin. This grant seeks to delineate the structure and function of colibactin in order to test the hypothesis that it plays a causal role in colorectal cancer formation. This work will illuminate new strategies for the treatment and prevention of colorectal cancer.

PI_NAMEs: HERZON, SETH B. (contact);JOBIN, CHRISTIAN

PROGRAM_OFFICER_NAME: JOHNSON, RONALD L

PROJECT_TERMS: Achievement;Aerobic;Affinity;Amines;Anabolism;Bacteria;Binding;Biochemical;Biological;carcinogenesis;carcinogenicity;Cells;chemical synthesis;Chemistry;Clustered Regularly Interspaced Short Palindromic Repeats;colon cancer patients;Colorectal Cancer;colorectal cancer prevention;colorectal cancer treatment;Complex;crosslink;Crystallography;Cyclization;cyclopropane;Degradation Pathway;design;Detection;Development;Diagnosis;Disease;DNA;DNA Binding;DNA Crosslinking;DNA Interstrand Crosslinking;DNA Repair Pathway;Enzymatic Biochemistry;Enzymes;Epidemiology;Epithelial Cells;Escherichia coli;Evaluation;Funding;Future;Gene Cluster;Genes;Genetic;Genomics;genotoxicity;Goals;Grant;Half-Life;Hand;Human;Hydrolysis;Imines;Immune response;Incubated;Induced Mutation;inhibitor;insight;Intestines;Isomerism;Label;Lactams;Link;Malignant Neoplasms;Maps;Mass Spectrum Analysis;Mediating;Mediator;Membrane Transport Proteins;Metabolic;Methods;microbiome;microbiome composition;microbiota;Modeling;Molecular;Mutagens;Mutation;Mutation Analysis;Natural Source;novel therapeutic intervention;Nucleotides;Organism;oxidation;pathogenic Escherichia coli;Pathway interactions;Periodicity;pharmacophore;Phenotype;Physiological;Physiology;Play;prevent;Prevention;Protein Isoforms;Resistance;resistance mechanism;response;Role;screening;small molecule;Stable Isotope Labeling;Structure;Synthesis Chemistry;tandem mass spectrometry;Testing;Time;tool;treatment response;Tumor Promotion;tumorigenesis;whole genome;Work

PROJECT_TITLE: Structural and functional studies of colibactin

STUDY_SECTION: SBCB

STUDY_SECTION_NAME: Synthetic and Biological Chemistry B Study Section[SBCB]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Hematology;Machine Learning and Artificial Intelligence;Neurosciences;Stroke

ORG_CITY: BALTIMORE

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: NARRATIVE This research proposal is designed to optimize the speed and evaluate the accuracy of a novel pH MRI technique for identifying stroke patients with salvageable brain regions, as well as patients at increased risk for developing hemorrhage after an acute ischemic stroke. The results would enhance patient selection for treatment, extend the therapeutic time window, and improve the risk-benefit ratio of recanalization therapies.

PI_NAMEs: HEO, HYE YOUNG  (contact)

PROGRAM_OFFICER_NAME: BOSETTI, FRANCESCA

PROJECT_TERMS: 3-Dimensional;Acceleration;Acidosis;Acute;acute stroke;Alteplase;Amides;Animal Model;Animals;Area;Benign;blood-brain barrier permeabilization;Brain hemorrhage;Brain imaging;Brain region;Cause of Death;Chemicals;Clinic;Clinical;clinical translation;Clinical Trials;Death Rate;Decision Making;deep learning;deep learning algorithm;deep learning model;design;detection sensitivity;diagnostic accuracy;Diffusion;Diffusion Magnetic Resonance Imaging;disability;Eligibility Determination;endovascular thrombectomy;Excision;Frequencies;Goals;Hemorrhage;Hour;Human;human imaging;Image;imaging modality;Imaging Techniques;improved;Incidence;Infarction;Intervention;Intravenous;Ischemia;Ischemic Penumbra;Ischemic Stroke;Magnetic Resonance Imaging;Metabolism;Methods;Morbidity - disease rate;mortality;multimodality;novel;Outcome;Patient Selection;Patients;Perfusion;perfusion imaging;Physiologic pulse;Physiological;Population;predict clinical outcome;Probability;Protocols documentation;Protons;radio frequency;Reperfusion Therapy;Research Proposals;Retrospective Studies;Risk;risk prediction;risk/benefit ratio;Scanning;Selection for Treatments;Sensitivity and Specificity;Signal Transduction;Speed;standard care;Stroke;stroke patient;stroke therapy;Symptoms;targeted treatment;Techniques;Testing;Therapeutic;Therapeutic Intervention;thrombolysis;Time;time use;Tissues;Training;Translating;Translations;transmission process;treatment effect;United States;Variant;Visualization;Work

PROJECT_TITLE: Ultrafast Quantitative pH MRI for Acute Ischemic Stroke Patients

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: PHILADELPHIA

ORG_DEPT: PATHOLOGY

ORG_NAME: THOMAS JEFFERSON UNIVERSITY

ORG_STATE: PA

PHR: Narrative Enhanced endoplasmic reticulum (ER)-mitochondrial contact formation with local IP3 receptor enrichment and intensified calcium signaling has been claimed as causative factor in mitochondrial dysfunction associated with non-alcoholic fatty liver and obesity. However, the molecular mechanisms of this local communication and of several mitochondrial Ca2+ effectors are poorly understood. The proposed work will help to delineate the structure-function correlation of the ER-mitochondrial contacts in hepatocytes and will provide a new analytical toolkit for quantitative and effective evaluation of their ultrastructure for a range of scientists.

PI_NAMEs: CSORDAS, GYORGY ;HAJNOCZKY, GYORGY  (contact)

PROGRAM_OFFICER_NAME: BURGESS-BEUSSE, BONNIE L

PROJECT_TERMS: 3-Dimensional;Affinity;Autophagocytosis;BCL2L1 gene;Binding;Calcium;Calcium Signaling;Cell Line;Cell Respiration;Cell Survival;cell type;Cells;Cellular biology;Clustered Regularly Interspaced Short Palindromic Repeats;Communication;Communication Research;Competence;Complex;Computer software;Coupling;Cytoplasm;Data;Data Set;Dependence;Descriptor;Dimensions;Disease;Electron Microscopy;Elements;Endoplasmic Reticulum;Energy Metabolism;Evaluation;Fatty Liver;Functional impairment;Genetic;Geometry;Health;Hela Cells;Hepatic;Hepatocyte;Hormones;Image;imaging approach;immune function;Impairment;in vivo imaging;Laboratories;Linear Models;Link;lipid biosynthesis;lipid metabolism;Liver;Liver diseases;Mammalian Cell;Measures;Mediating;Medicine;Membrane;Metabolic;Metabolism;Methods;microscopic imaging;Mitochondria;mitochondrial dysfunction;mitochondrial membrane;Modeling;Molecular;Molecular Analysis;Molecular Target;Morphology;mouse model;Movement;nano;nanoscale;Neurons;non-alcoholic fatty liver;non-alcoholic fatty liver disease;novel;Nucleotides;Obesity;Organ;Organelles;Outer Mitochondrial Membrane;Pharmaceutical Preparations;Phenotype;Physiological;Process;Production;protein complex;Protein Isoforms;Proteins;Proteomics;Quantitative Evaluations;Reactive Oxygen Species;Reagent;receptor;Regulation;Research Personnel;Role;scaffold;Scheme;Scientist;Signal Transduction;Site;software development;Specificity;Structure;Structure-Activity Relationship;Techniques;Testing;Tissues;tool;uptake;Vesicle;Work

PROJECT_TITLE: ER-mitochondrial communication in calcium signaling, energy metabolism and liver disease

STUDY_SECTION: MIST

STUDY_SECTION_NAME: Molecular and Integrative Signal Transduction Study Section[MIST]


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Gene Therapy;Genetics;Immunotherapy;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: Project Narrative/Lay Summary Although immuno-oncology approaches have benefitted many cancer patients, immunotherapy approaches for glioblastoma (GBM) have failed to demonstrate clinical benefit. Based on promising preclinical and early clinical data, we propose the use of an oncolytic virus strain armed with an immunostimulatory gene, the toll- like receptor 2 agonist NAP, as a novel antitumor approach against GBM that can enhance immunotherapeutic efficacy and result in synergy when combined with immune checkpoint inhibitors. We also propose to further increase activity by using IDO and JAK inhibitors in order to address a common mechanism of resistance to immune checkpoint inhibitors and enhance viral replication, prior to comprehensively testing both the efficacy and safety of this multipronged strategy on a path to clinical translation.

PI_NAMEs: GALANIS, EVANTHIA  (contact)

PROGRAM_OFFICER_NAME: SOMMERS, CONNIE L

PROJECT_TERMS: Address;Agonist;Algorithms;Animal Model;anti-tumor immune response;Antibodies;Antigens;Biodistribution;Cancer Patient;CD46 Antigen;CD8B1 gene;Cell Death;Cells;circulating biomarkers;Clinical;Clinical Data;clinical translation;combinatorial;Combined Modality Therapy;conventional therapy;cytokine;Data;Dendritic Cells;Dose;efficacy evaluation;Engineering;experience;FDA approved;Gene Expression;Genes;Genetic Engineering;Glioblastoma;Gliomagenesis;Helicobacter pylori;Human;imaging study;Immune checkpoint inhibitor;Immune response;Immunocompetent;immunogenic cell death;immunogenicity;Immunologic Markers;Immunologics;Immunooncology;Immunophenotyping;Immunosuppression;Immunotherapeutic agent;immunotherapeutic virotherapy;Immunotherapy;immunotherapy trials;improved;inhibitor;innovation;Interferons;ITGAX gene;Lead;Macaca mulatta;Malignant Neoplasms;Mammalian Cell;Measles;Measles virus;Modeling;Molecular;Mus;Mutation;Natural Killer Cells;neoantigens;neutrophil;novel;Oncolytic;oncolytic virotherapy;Oncolytic viruses;Outcome;Pathway interactions;patient derived xenograft model;Patients;Pattern;PD-1 blockade;PD-1 inhibitors;PD-1/PD-L1;Penetration;permissiveness;Phase;phase I trial;phase III trial;Population;pre-clinical;Predisposition;Primates;Prognosis;Proteins;Recommendation;Recurrence;Regulatory T-Lymphocyte;Resistance;resistance mechanism;response;Safety;safety testing;Signal Transduction;Spleen;synergism;Testing;Therapeutic;TLR2 gene;Toxicology;Transgenes;Treatment Efficacy;Tryptophan 2,3 Dioxygenase;tumor;Tumor Antigens;tumor microenvironment;Tumor Tissue;Tumor-infiltrating immune cells;Up-Regulation;Vaccines;Viral;Virotherapy;Virus Diseases;Virus Replication;Work

PROJECT_TITLE: Novel multipronged Immunovirotherapy Approach for GBM Treatment

STUDY_SECTION: DT

STUDY_SECTION_NAME: Developmental Therapeutics Study Section[DT]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Aging;Cancer;Clinical Research;Colorectal Cancer;Digestive Diseases;Health Services;Prevention;Social Determinants of Health;Urologic Diseases

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative Non-metastatic cancer patients and their physicians need information about the short-term and long-term risks of recurrence, and how these risks vary with age, gender, race-ethnicity, other demographic characteristics, tumor characteristics, and received treatment. We aim to make the Georgia Cancer Registry the world’s first cancer registry to record recurrence information for four cancers that account for 4 in 9 incident cancers, and to use this information to describe recurrence patterns. Given its large and diverse population and high quality cancer registry, Georgia is the ideal setting to implement the world’s first registry of cancer recurrences.

PI_NAMEs: LASH, TIMOTHY L.;WARD, KEVIN C (contact)

PROGRAM_OFFICER_NAME: MARIOTTO, ANGELA B

PROJECT_TERMS: Age;Aging;American;American Cancer Society;American College of Surgeons;anti-cancer research;authority;Breast;cancer care;Cancer Center;Cancer Patient;cancer recurrence;cancer risk;cancer statistics;Cancer Survivor;cancer therapy;cancer type;Caring;Cause of Death;Centers for Disease Control and Prevention (U.S.);Cessation of life;Characteristics;Clinic;Clinical;clinical care;Colorectal;Colorectal Cancer;comorbidity;Comparative Effectiveness Research;complex data;Contracts;Data;data streams;Decision Making;Diagnosis;Disease;Ensure;Ethnic Origin;follow-up;Foundations;Gender;Health Insurance;Heterogeneity;hospice environment;Hospitals;improved;indexing;Infrastructure;innovation;Insurance Coverage;Journal of the National Cancer Institute;knowledge base;Leadership;Learning;Legal;Link;Lymphoma;Malignant Breast Neoplasm;Malignant neoplasm of prostate;Malignant Neoplasms;Medicaid;Medical Oncology;Medical Records;Medicare;member;Methods;Monitor;mortality;National Cancer Institute;National Cancer Program;neoplasm registry;Nonmetastatic;Outcome;Pathology Report;Patients;Pattern;Pharmacy facility;Physicians;Population;population based;Population Heterogeneity;Process;programs;Prostate;Protocols documentation;Public Health;Public Health Schools;Published Comment;Quality of Care;Race;Records;Recurrence;Registries;Reporting;Research;Research Personnel;Resource Sharing;Risk;risk stratification;Rural;SEER Program;sex;Signal Transduction;Socioeconomic Status;Specimen;surveillance data;Survival Rate;Survivors;tumor;Universities

PROJECT_TITLE: Registering Cancer Recurrences in the Georgia Cancer Registry

STUDY_SECTION: CHSA

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology A Study Section[CHSA]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Project Narrative Hypertension (high blood pressure), present in almost 50% of the population of the United States, is a major risk factor for heart and blood vessel disease leading to premature death and disability. Retention of salt and water by the kidney is required for hypertension to develop. This application will increase our understanding of the mechanisms whereby the kidney renin-angiotensin system regulates salt and water excretion, suggesting new molecular targets for the treatment and prevention of hypertension.

PI_NAMEs: KELLER, SUSANNA R (contact)

PROGRAM_OFFICER_NAME: VARAGIC, JASMINA

PROJECT_TERMS: absorption;Acute;Address;Adult;Affect;Age;Agonist;AGTR2 gene;Angiotensin II;Angiotensin III;Angiotensins;antagonist;Apical;Blood Pressure;blood pressure control;blood pressure reduction;Blood Vessels;Cell membrane;Cells;Cessation of life;Chronic;Cyclic AMP;Cyclic AMP Receptor Protein;Cyclic AMP-Dependent Protein Kinases;Cyclic GMP;Defect;Development;disability;Disease;Dopamine;Essential Hypertension;Excretory function;Fenoldopam;Functional disorder;Funding;Goals;Heart;Human;Hypertension;hypertension prevention;hypertensive;Impairment;in vivo;Inbred SHR Rats;Infusion procedures;Intracellular translocation;Kidney;Knockout Mice;Mediating;Microtubules;Molecular;molecular targeted therapies;Mus;Natriuresis;normotensive;novel drug class;Pathogenesis;Pathway interactions;Peptides;Pharmacotherapy;Phosphoric Monoester Hydrolases;Population;premature;prevent;Production;Protein phosphatase;Proximal Kidney Tubules;Rattus;receptor;Receptor Activation;Receptor Inhibition;Receptor Signaling;Receptor, Angiotensin, Type 1;recruit;Regulation;Renin-Angiotensin System;response;restoration;Risk Factors;Role;saluretic;Signal Pathway;Signal Transduction;Site;Sodium;Sodium Chloride;Techniques;Testing;therapeutic target;Type 2 Angiotensin II Receptor;United States;Water

PROJECT_TITLE: Renal AT2 Receptors in Hypertension

STUDY_SECTION: HM

STUDY_SECTION_NAME: Hypertension and Microcirculation Study Section[HM]


NIH_SPENDING_CATS: Cardiovascular;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Human Genome;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: This application from an established and highly productive cardiovascular and stem cell scientist focuses on the ways in which cells regulate the genes that they express so that scientists will be better able to promote regenerative therapies for cardiac diseases such as heart attacks. Recent studies indicate that DNA is organized in highly complex ways within the nucleus and that gene expression is regulated, at least in part, by spatial localization within nuclear compartments. DNA tethered tightly to the inner nuclear membrane in regions known as lamin associated domains, is repressed, and this proposal will seek to explore the emerging concept that cellular identity can be manipulated by controlling the regions of DNA that associate with the nuclear membrane with the goal of enhancing cardiac regeneration.

PI_NAMEs: EPSTEIN, JONATHAN A. (contact)

PROGRAM_OFFICER_NAME: SCHRAMM, CHARLENE A

PROJECT_TERMS: 3-Dimensional;Amino Acids;Architecture;aurora B kinase;cancer cell;Cardiac;Cardiac Myocytes;cardiac regeneration;Cardiovascular Diseases;Cardiovascular system;Cell division;Cell Nucleus;Cells;Characteristics;Chromatin;Code;Complex;Data;Daughter;daughter cell;DNA;DNA biosynthesis;epigenetic memory;Epigenetic Process;Epitopes;Excision;fatty acid metabolism;Foundations;Gene Expression;Gene Expression Regulation;Genes;Genome;genome-wide;genomic locus;Glucose;Goals;Heart Diseases;Histones;innovation;Lamins;Malignant Neoplasms;Mediating;member;Metabolic;Metabolism;Mitosis;Modeling;Myocardial Infarction;novel;Nuclear;Nuclear Envelope;Nuclear Inner Membrane;Pattern;Phosphorylation;Predisposition;Productivity;programs;Publishing;Pyruvate Kinase;regenerative approach;regenerative therapy;Regulation;Repression;Scientist;Signal Transduction;stem cells;Tail;Testing;transdifferentiation

PROJECT_TITLE: Cardiac lineage determination and nuclear architecture


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Aging;Biotechnology;Chronic Liver Disease and Cirrhosis;Diabetes;Digestive Diseases;Genetics;Human Genome;Liver Disease;Nutrition;Obesity

ORG_CITY: SAINT LOUIS

ORG_DEPT: PEDIATRICS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Fasting and caloric restriction are effective to treat patients with pre-diabetes or non-alcoholic fatty liver disease (NAFLD), but intensive lifestyle changes are difficult for many to implement and sustain. We discovered a key pathway in the liver, which is activated during fasting, and is sufficient to treat pre-diabetes and NAFLD in mice. In this proposal, we will define how ARG2 mediates its therapeutic effects, and examine its efficacy to bring forth new therapies that mimic the actions of ARG2 to ultimately treat obesity-related metabolic disease.

PI_NAMEs: ZHANG, YIMING  (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Aging;aging reversal;Amino Acids;ARG2 gene;arginase;Arginine;Arginine deiminase;Attenuated;Biological Response Modifier Therapy;Biology;Caloric Restriction;Calories;carbohydrate transport;Carbohydrates;Cardiovascular system;Catabolism;cell type;Cells;Chromatin;Clinical;clinically significant;Data;defined contribution;deprivation;Diabetes Mellitus;Diabetic mouse;Diet;dietary;Disease Progression;Disease Resistance;effective therapy;efficacy evaluation;energy balance;Energy Metabolism;Enzymes;Expenditure;Fasting;fasting glucose;Fatty acid glycerol esters;Fatty Liver;FDA approved;FGF21 gene;fibroblast growth factor 21;Genetic;genome-wide;Genomics;Glucose;Glucose Transporter;Goals;Health;Hepatic;Hepatocyte;Homeostasis;Hydrolase;Hydrolysis;improved;Inflammatory;innovation;innovative technologies;Insulin Resistance;insulin sensitivity;Intermittent fasting;Knockout Mice;Laboratories;Life Style;Life Style Modification;lifestyle intervention;Liver;liver inflammation;Longevity;Mediating;Metabolic;Metabolic Diseases;Metabolic syndrome;Modeling;mortality;mouse model;Mus;non-alcoholic fatty liver disease;NOS2A gene;novel;novel therapeutic intervention;novel therapeutics;Obesity;obesity genetics;Outcome;overexpression;Pathway interactions;Patients;Peripheral;Persons;pharmacologic;Physiological;Population;Prediabetes syndrome;prevent;Process;Reagent;Regulatory Pathway;response;screening;Signal Transduction;single cell genomics;single cell sequencing;small molecule;Techniques;Technology;Testing;Therapeutic;Therapeutic Effect;Thermogenesis;transcription factor;transcriptome;transcriptomics;Treatment Efficacy;Work

PROJECT_TITLE: Leveraging arginine catabolism to treat metabolic diseases


NIH_SPENDING_CATS: Breast Cancer;Cancer;Genetics;Immunotherapy;Radiation Oncology;Women's Health Research

PHR: Narrative We found that the protein which has received tremendous attention for its role in immune response, the programmed death ligand 1 (PD-L1) has novel nuclear function and can promote tumor cell growth by regulating chromosome division. These observations provide strong rational to target nuclear PD-L1 and block tumor growth. Especially in TNBC, PD-L1 dependent cell growth is essential for breast cancer survival, and therefore, this strategy could have significant clinical impact, especially to treat patients who might not respond to current PD-L1 antibody.

PI_NAMEs: LOU, ZHENKUN ;WANG, LIEWEI  (contact)

PROGRAM_OFFICER_NAME: WITKIN, KEREN L

PROJECT_TERMS: Acetylation;Adjuvant Chemotherapy;Affect;Animal Model;Antibodies;Attention;Binding;Breast Cancer Cell;Breast Cancer Patient;breast cancer progression;breast cancer survival;cancer subtypes;cancer therapy;Cell Cycle;Cell Cycle Regulation;Cell division;cell growth;Cell Nucleus;Cell Proliferation;chemoradiation;chemotherapy;Chromosomal Stability;Chromosome Segregation;Chromosomes;Clinical;cohesin;cohesion;Combined Modality Therapy;Data;design;Disease;Epidermal Growth Factor Receptor;Estrogen Receptors;Event;Excision;extracellular;Genome Stability;glycosylation;high risk;Human;Immune;Immune response;Immune system;immunodeficiency;In Vitro;knock-down;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Gland Parenchyma;Mitosis;Mitosis Inhibition;mouse model;Neoadjuvant Therapy;neoplastic cell;Normal Cell;novel;novel strategies;Nuclear;Operative Surgical Procedures;overexpression;Pathogenesis;Pathway interactions;Patients;Postoperative Period;Progesterone Receptors;programmed cell death ligand 1;programmed cell death protein 1;Proliferating;protein complex;Proteins;radiation response;Radiation therapy;receptor;Recurrence;Regulation;Residual Neoplasm;Residual state;response;Risk Reduction;Role;segregation;Signal Transduction;standard care;T cell regulation;T cell response;T-Cell Activation;targeted treatment;Testing;Therapeutic antibodies;Therapeutic Uses;transmission process;treatment response;triple-negative invasive breast carcinoma;tumor;tumor growth;Tumor Immunity;Tumor Promotion;Variant;Work;Xenograft procedure

PROJECT_TITLE: The role of nuclear PD-L1 in breast tumor cell division, progression and therapy response

STUDY_SECTION: MONC

STUDY_SECTION_NAME: Molecular Oncogenesis Study Section[MONC]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Bioengineering;Breast Cancer;Cancer;Women's Health Research

ORG_CITY: TEMPE

ORG_DEPT: MISCELLANEOUS

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

ORG_STATE: AZ

PHR: Project Narrative Exposure of unfixed tissue or liquid biospecimens to temperatures at which they are thawed (which in many cases is well below the common laboratory freezer temperature of -20 °C) can dramatically impact clinical research results—a phenomenon that has been shown to produce an inordinate number of false leads in biomedical research. No criteria for establishing biospecimen sample integrity have been set and no quality thresholds exist that must be met before NIH/NCI (taxpayer) funds are spent on studies involving archived research specimens. This project will develop bright-pink-to-clear color change-based indicators designed for a dozen different biospecimen handling/storage requirements that, ultimately, will be implemented by placement into custom-designed dual-chambered, flex-activated (like a glow-stick) see-through devices that can be housed on (notched into) the outside of a specially designed sample storage vial—and thus kept with (but not touching) the individual specimen over the entire course of its existence.

PI_NAMEs: BORGES, CHAD R (contact)

PROGRAM_OFFICER_NAME: AGRAWAL, LOKESH

PROJECT_TERMS: Adherence;Agreement;Aliquot;American;American Society of Clinical Oncology;Archives;Biological;biological specimen archives;Biomedical Research;Biopsy;Blood;Blood specimen;cell free DNA;Chemistry;Clinical;Clinical Research;Collection;college;Color;cost;Cryopreservation;Custom;design;Development;Device Designs;Devices;Documentation;Ensure;ERBB2 gene;Estrogen Receptors;evidence base;Excision;Exposure to;Freezing;Funding;Guidelines;Hour;Ice;improved;Individual;interest;Ischemia;Kinetics;Laboratories;Life;Liquid substance;Magnesium Chloride;Malignant Breast Neoplasm;Malignant Neoplasms;notch protein;novel;Oncologist;Operative Surgical Procedures;Oxalates;Paper;Pathologist;permanganate;Plasma;Process;prospective;prototype;quality assurance;Quality Control;Reaction;Reagent;Reproducibility;Research Personnel;Running;sample collection;sample fixation;Sampling;Serum;Specimen;System;Technology;Temperature;Testing;Time;Tissue Fixation;Tissue Inhibitor of Metalloproteinase-1;Tissues;tool;United States National Institutes of Health;Vascular Endothelial Growth Factors;Vial device;Visual

PROJECT_TITLE: Aliquot-level visual indicators of biospecimen exposure to thawed conditions


NIH_SPENDING_CATS: Autoimmune Disease;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Multiple Sclerosis;Neurodegenerative;Neurosciences

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Project Narrative Multiple sclerosis (MS) is one of the most prevalent (~1 million MS patients in the US) and debilitating neurological diseases that affects patients in early adulthood and is the second leading cause of non-traumatic paralysis. Importantly, the spinal cord is damaged in MS, potentially leading to neurological deterioration, however, magnetic resonance imaging (MRI) and in particular, diffusion MRI are poorly suited to offer information about the biological substrates of MS in the spinal cord primarily because of its size and constant motion. Recently advancements in diffusion MRI (and associated modeling of diffusion contrasts) have been made and hold the promise of providing insight into the biophysical substrates of tissue damage in MS, but the application in the cervical spinal cord, the relationship between diffusion MRI and conventional MRI, and a more complete description of neurological damage in the spinal cord with advanced diffusion MRI has not been adequately evaluated or vetted, which is the thrust of this proposal.

PI_NAMEs: SMITH, SETH A (contact)

PROGRAM_OFFICER_NAME: UTZ, URSULA

PROJECT_TERMS: Address;Affect;Age;Animal Model;Architecture;Area;Atrophic;Attention;Axon;axon injury;Biological;biophysical model;Biophysics;Brain;Cervical spinal cord structure;Chronic;Clinical;Clinical assessments;Clinical/Radiologic;clinically relevant;cohort;Critiques;Data;density;Deterioration;Diffusion;Diffusion Magnetic Resonance Imaging;disability;Disease;Disease Progression;Electron Microscopy;emerging adult;Evaluation;Evolution;Gender;Goals;Grant;gray matter;Health;healthy volunteer;Human;Image;improved;in vivo;indexing;Inflammation;insight;Knowledge;Lesion;Literature;Magnetic Resonance Imaging;Measurement;Measures;Methods;Modeling;Motion;Multiple Sclerosis;multiple sclerosis patient;Nervous System Disorder;Nervous System Physiology;Nervous System Trauma;neural;Neurites;Neurologic;Neurologic Deficit;Neurological disability;Neurological status;neuroprotection;novel;Paint;Paralysed;Pathologic;Pathology;Patients;Process;Publications;Publishing;Radiology Specialty;recruit;Relapsing-Remitting Multiple Sclerosis;Reporting;Reproducibility;Scanning;Sensorimotor functions;Societies;Specificity;Spinal Cord;Spinal cord damage;Spinal Cord Diseases;Spinal Cord Lesions;Synapses;Techniques;Testing;Time;Tissues;tool;Validation;Variant;white matter

PROJECT_TITLE: Evaluating Advanced Diffusion of the Human Spinal Cord: Application to MS

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


NIH_SPENDING_CATS: Autoimmune Disease;Brain Disorders;Multiple Sclerosis;Neurodegenerative;Neurosciences

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PHR: PUBLIC HEALTH RELEVANCE: Multiple sclerosis (MS), the most frequent inflammatory disease of the central nervous system (CNS), afflicts up to 2.5 million people globally. It begins at age 20–50 years, and there is no known cure. Medications used to treat MS are modestly effective, at least in relapsing remitting MS, but all available therapies are immunosuppressive, and thus predispose to opportunistic infections including JC virus leading to progressive multifocal leukoencephalopathy (PML), which may be fatal. To date, no therapy has been advanced that specifically targets astrocytes, which are key players in CNS innate immunity, and which may be targeted without immunosuppression.

PI_NAMEs: GERZANICH, VLADIMIR  (contact)

PROJECT_TERMS: Acute;Age;Astrocytes;Attenuated;Axon;Binding;CCL2 gene;Central Nervous System;Central Nervous System Diseases;chemokine;Chronic;Chronic Phase;Cicatrix;Clinical;cytokine;Data;Demyelinations;Disease;Disease Progression;edg-1 Protein;edg-3 Protein;Experimental Autoimmune Encephalomyelitis;experimental study;Female;Genetic;genetic approach;Genetic Transcription;Glyburide;Immunosuppression;In Vitro;in vivo;Individual;Inflammation;Inflammatory;Innate Immune Response;insight;Interleukin-6;JC Virus;Laboratories;Maintenance;male;Mediating;Microglia;Molecular;monocyte;Multiple Sclerosis;Mus;Natural Immunity;Nerve Degeneration;Nervous System Physiology;Neuroglia;NOS2A gene;nuclear factors of activated T-cells;oligodendrocyte-myelin glycoprotein;Opportunistic Infections;Oral;patch clamp;Pathologic;Persons;Pharmaceutical Preparations;pharmacologic;Play;preservation;Progressive Multifocal Leukoencephalopathy;public health relevance;Publishing;Regulation;Relapsing-Remitting Multiple Sclerosis;Role;Severity of illness;Signal Transduction;sphingosine 1-phosphate;Sphingosine-1-Phosphate Receptor;Spinal Cord;Symptoms;Therapeutic;Therapeutic immunosuppression;Up-Regulation;white matter;Work

PROJECT_TITLE: Sur1-Trpm4 regulation of the pro-inflammatory astrocytic secretome in EAE

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Cancer;Genetics

ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: Project Narrative The properly regulated expression of protein-coding genes transcribed by RNA polymerase II (RNAPII) is essential for normal growth and development; disturbances in this regulation are hallmarks of cancer and other diseases. Both the transcription cycle of RNAPII and the cell division cycle are governed by the opposing actions of cyclin-dependent kinases (CDKs) and protein phosphatases, which have emerged as potential targets in cancer therapy. Comprehensive models of how CDKs and phosphatases work together during the transcription cycle, and how this coordination is disrupted in cancer cells, are needed both to deepen understanding of normal gene regulation and to guide efforts to target the RNAPII machinery therapeutically.

PI_NAMEs: FISHER, ROBERT P (contact)

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TERMS: Binding;cancer cell;cancer therapy;Cell Cycle;Cell Cycle Regulation;Cell division;Cells;Chromatin;Code;Collaborations;Complex;Coupling;Cyclin-Dependent Kinases;Disease;Dissection;Drug Targeting;Elongation Factor;Ensure;Event;Family;Gene Expression;Gene Expression Regulation;Genetic Transcription;genome editing;genome-wide;Genomics;Goals;Growth and Development function;Human;Link;Malignant Neoplasms;member;Messenger RNA;Modeling;Mutation;Pathway interactions;Phase;phosphatase-1 kinase;Phosphoric Monoester Hydrolases;Phosphorylation;promoter;Protein Dephosphorylation;protein expression;Protein phosphatase;Protein Phosphatase 2A Regulatory Subunit PR53;recruit;Regulation;response;RNA Polymerase II;Role;Signal Transduction;Site;small molecule;Specificity;Substrate Specificity;Testing;Therapeutic;transcription factor TFIIH;Transcriptional Regulation;Work

PROJECT_TITLE: Cyclin-dependent kinase control of cell-division and transcription cycles

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


PHR: Narrative The proposed research aims to detect and characterize magnetic resonance imaging signals in white matter associated with neural activity and brain function, and quantify their relationships with cortical activity and their biophysical origins. White matter signals in fMRI have only recently been detected reliably, and these studies will validate their interpretation as indicators of neural processing and provide a foundation for future applications evaluating white matter disorders.

PI_NAMEs: GORE, JOHN C (contact)

PROGRAM_OFFICER_NAME: BABCOCK, DEBRA J

PROJECT_TERMS: Action Potentials;Alzheimer's Disease;Area;Back;Biophysical Process;Biophysics;Blood;Blood flow;blood oxygen level dependent;blood oxygenation level dependent response;Blood Volume;Brain;Characteristics;Contrast Media;Coupling;Data;Degenerative Disorder;design;Detection;detection method;detection sensitivity;Development;Diffusion;Diffusion Magnetic Resonance Imaging;Disease;Event;Exhibits;Face;Failure;Fingers;Foundations;Functional Magnetic Resonance Imaging;fusiform face area;Future;Goals;gray matter;hemodynamics;Human;Hypercapnia;Image;interest;Laboratories;Magnetic Resonance Imaging;Mathematics;Measurable;Measurement;Measures;Methods;Modeling;Motor;Multiple Sclerosis;Nature;neural;Neuroglia;Noise;nonhuman primate;Oxygen;Parkinson Disease;Pathologic;Physiologic pulse;Physiological;Predisposition;Protocols documentation;Reporting;Research;Residual state;response;Rest;Role;Short-Term Memory;Signal Transduction;Stimulus;Stroke;Structure;success;Techniques;tractography;Uncertainty;Variant;Vasodilation;Visual;white matter;Work

PROJECT_TITLE: Biophysical basis of functional MRI of white matter

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


NIH_SPENDING_CATS: Aging;Genetics

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE The prevalence of neurological disorders has doubled in the past 20 years and continues to escalate such that it is estimated that over 13.8 million people in the US will be afflicted with a neurological disorder by 2050. Defects in the cellular pathways that limit the abundance or facilitate the removal of potentially toxic proteins have been linked to increased neurological dysfunction and decreased overall longevity. Research within this proposal focuses on combatting aging-associated disorders through the targeted manipulation of factors that can reduce the toxicity of defective proteins by either limiting their production or enhancing their destruction.

PI_NAMEs: BENNETT, ERIC J (contact)

PROGRAM_OFFICER_NAME: PHILLIPS, ANDRE W

PROJECT_TERMS: aging related;Biochemical;Biogenesis;Cell Line;Cell Proliferation;Cells;Cellular Stress;Chromosome abnormality;Chronic;combat;Complex;Defect;Detection;Development;Disease;Dissection;DNA biosynthesis;Excision;fitness;Genetic Transcription;genome editing;Goals;Health;healthspan;Human;Human Pathology;improved;Length;Ligase;Link;Longevity;Messenger RNA;Molecular;Mutation;Nature;neoplastic cell;Nervous System Disorder;Neurodegenerative Disorders;Neurologic Dysfunctions;Outcomes Research;Pathology;Pathway interactions;Persons;Prevalence;Process;Production;Proliferating;Proteins;Proteome;proteostasis;proteostasis loss;proteotoxicity;Quality Control;Recycling;Research;response;Ribosomes;Stress;Structure;System;Toxic effect;Translation Initiation;Translations;Triage;Ubiquitin;ubiquitin ligase;Variant

PROJECT_TITLE: Leveraging ubiquitin-dependent regulatory mechanisms to improve proteome quality in health and disease


NIH_SPENDING_CATS: Biomedical Imaging;Brain Disorders;Clinical Research;Epilepsy;Neurodegenerative;Neurosciences;Precision Medicine;Prevention

PHR: PROJECT NARRATIVE The ultimate goal of this study is to develop Magnetic Resonance Imaging connectivity based biomarkers of individual treatment outcome prediction for patients with temporal lobe epilepsy. This would lead to increases in the success rate of potentially risky treatments, and more efficient clinical management of this common debilitating disorder.

PI_NAMEs: MORGAN, VICTORIA L (contact)

PROGRAM_OFFICER_NAME: WHITTEMORE, VICKY R

PROJECT_TERMS: Address;Algorithms;Anatomy;anti-epileptic agents;Anxiety;Benchmarking;Biological Markers;biomarker identification;Brain region;Cessation of life;Characteristics;Clinical;Clinical assessments;clinical diagnosis;Clinical Management;clinically significant;Cognitive;Cognitive deficits;Development;Disease;early detection biomarkers;Early identification;Epilepsy;Epileptogenesis;Evolution;Excision;Foundations;Freedom;Frequencies;Functional Magnetic Resonance Imaging;Goals;high risk;Hippocampus;image processing;improved;Individual;Intractable Epilepsy;Investigation;Lateral;Longitudinal Studies;Magnetic Resonance Imaging;Measures;medial temporal lobe;Mental Depression;Methods;Morbidity - disease rate;mortality;National Institute of Neurological Disorders and Stroke;neocortical;Neurocognitive;Newly Diagnosed;Operative Surgical Procedures;Outcome;outcome prediction;Partial Epilepsies;Patients;Pharmaceutical Preparations;pharmacologic;Pharmacotherapy;Play;Population;Prediction of Response to Therapy;predictive marker;Quality of life;Refractory;Research;response;Rest;Role;Scanning;Scheme;Seizures;Sensitivity and Specificity;Structure;success;surgery outcome;Temporal Lobe;Temporal Lobe Epilepsy;Testing;Translating;treatment comparison;Treatment outcome;treatment response;Work

PROJECT_TITLE: MRI Connectivity Biomarkers of Treatment Response in Focal Epilepsy

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


ADMINISTERING_IC: NR

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Dementia;Neurodegenerative;Neurosciences;Rehabilitation

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: Project Narrative: We aim to modify cognitive, behavioral, and functional capacity and slow the conversion to dementia in older adults with amnestic mild cognitive impairment. This intervention as the potential to be widely disseminated in community settings in groups at risk for dementia, especially Alzheimer’s disease, and preventing or slowing the progression of dementia.

PI_NAMEs: HEFFNER, KATHI L (contact);LIN, FENG VANKEE

PROGRAM_OFFICER_NAME: HUSS, KAREN

PROJECT_TERMS: Activities of Daily Living;adaptive learning;Address;Alzheimer's Disease;amnestic mild cognitive impairment;Attention;Autonomic nervous system;Autonomic Pathways;Behavioral;Biofeedback Training;Blood;Brain;Breathing;Categories;Cognition;Cognitive;cognitive capacity;cognitive control;Cognitive deficits;cognitive enhancement;cognitive training;community setting;Data;Dementia;dementia risk;design;Discipline of Nursing;Distal;Double-Blind Method;Episodic memory;executive function;Exhalation;flexibility;follow-up;Frequencies;Goals;Guided imagery;Heart Rate;heart rate variability;Imagery;improved;Inhalation;instrumental activity of daily living;Intervention;Long-Term Effects;Measures;mild cognitive impairment;Nerve Degeneration;Neurobehavioral Manifestations;Neuronal Plasticity;neuropsychiatric symptom;Nonpharmacologic Therapy;novel;older adult;Outcome;Pathologic;Pathway interactions;Performance;Periodicals;Peripheral;Persons;pharmacologic;Phase;Physical Exercise;Populations at Risk;prevent;Process;processing speed;Randomized;randomized trial;Randomized, Controlled Trials;Relaxation;response;Rest;Science;Short-Term Memory;Strategic Planning;stressor;Support System;symptom management;Symptoms;Testing;theories;Thick;Time;Training;Vision;Waiting Lists;Work

PROJECT_TITLE: Targeting Autonomic Flexibility to Enhance Cognitive Training Outcomes in Older Adults with Mild Cognitive Impairment

STUDY_SECTION: BMIO

STUDY_SECTION_NAME: Behavioral Medicine, Interventions and Outcomes Study Section[BMIO]


ORG_CITY: CAMBRIDGE

ORG_NAME: HARVARD UNIVERSITY

ORG_STATE: MA

PHR: PROJECT NARRATIVE Diversity and inclusion in the biomedical workforce at all levels is critical to maintaining excellence. This grant seeks to address the issues of diversity and workforce development raised in the recent report by the Biomedical Workforce Advisory Committee through the development of a tailored academic and research-training program for post-baccalaureates interested in pursuing doctoral degrees in two broad areas of biomedical sciences, which we designate as the life and population sciences. The program will provide post-baccalaureates from disadvantaged backgrounds and groups underrepresented in the sciences with a one or two year mentored- research and academic experience at Harvard University.

PI_NAMEs: D'SOUZA, VICTORIA MANUEL;VELEZ-RUIZ, GISSELLE A (contact)

PROGRAM_OFFICER_NAME: AKACEM, LAMEESE DANA

PROJECT_TERMS: academic preparation;Academic Training;Address;Admission activity;Advisory Committees;Area;Arts;Biochemistry;Biological Sciences;Biomedical Research;career;Cellular biology;design;Development;disadvantaged background;Disparity population;diversity and inclusion;Doctor of Philosophy;Doctor's Degree;Education;education research;Educational workshop;Environment;experience;Faculty;Funding;Genetic;Goals;graduate school;graduate student;Grant;improved;Individual;Institution;interest;Interview;Knowledge;Learning;Mentors;Methods;Minority;National Institute of General Medical Sciences;Perception;physical science;Population;Population Sciences;Postbaccalaureate;Preparation;Process;Program Evaluation;programs;Reporting;Research;Research Training;Scholars Program;Science;skills;STEM career;Students;success;Training;Training and Education;training opportunity;Training Programs;undergraduate student;Underrepresented Minority;Underrepresented Populations;Underrepresented Students;Universities;Workforce Development;Writing

PROJECT_TITLE: Diversity in Biomedical Sciences Via Personalized Research and Education Programs

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - C[TWD-C]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Aging;Arthritis;Bioengineering;Biomedical Imaging;Chronic Pain;Clinical Research;Disability Research;Osteoarthritis;Pain Research

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: NARRATIVE Our overall goal is to identify cross-sectional and longitudinal local patterns of cartilage and bone interactions unique to patellofemoral joint osteoarthritis and determine the mediation effects of gait biomechanics and bone morphology on disease progression. We will conduct a longitudinal cohort study investigating 100 people with isolated patellofemoral joint osteoarthritis, followed for 2 years. This work is urgently needed to fully understand bone-cartilage interactions and reveal biomechanical risk factors for patellofemoral joint osteoarthritis progression.

PI_NAMEs: MAJUMDAR, SHARMILA ;SOUZA, RICHARD BRIAN (contact)

PROGRAM_OFFICER_NAME: ZHENG, XINCHENG

PROJECT_TERMS: Acceleration;Adult;Biochemistry;Biomechanics;Blood Vessels;bone;Bone remodeling;Cartilage;cartilage degradation;Collagen;Complex;Cross-Sectional Studies;Data;Degenerative polyarthritis;disability;Disease;Disease Progression;Enzymes;Etiology;Evaluation;Extracellular Matrix;feature extraction;Femur;follow-up;Functional disorder;Gait;Gait abnormality;Goals;Image;imaging biomarker;imaging study;Incidence;Individual;inhibitor;Invaded;Investigation;joint biomechanics;joint loading;Joints;Knee bone;Knee Osteoarthritis;knee pain;Longitudinal cohort study;Longitudinal Studies;Magnetic Resonance Imaging;Maps;Measures;Mechanics;Mediating;Mediation;Metabolic;Metabolism;Modality;Modeling;Morphology;Musculoskeletal;Outcome;Pain;Pathogenesis;Pattern;Peptide Hydrolases;Persons;Process;Proteoglycan;Protons;Questionnaires;radiological imaging;Relaxation;Resolution;Risk Factors;Role;Shapes;soft tissue;Source;Standardization;subchondral bone;substantia spongiosa;System;Thick;Time;Tissue imaging;tomography;treatment strategy;uptake;Variant;Work

PROJECT_TITLE: Simultaneous Imaging of Tissue Biochemistry and Metabolism associated with Biomechanics in Patella Femoral Joint Osteoarthritis


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Congenital Heart Disease;Congenital Structural Anomalies;Heart Disease;Infant Mortality;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Patients with congenital heart disease (CHD) are the fastest growing population of adults in the world. While patients with severe forms of CHD are surviving into adulthood, they face a disproportionate burden of arrhythmias and heart failure that leads to their morbidity and mortality, the cause of which is unknown.

PI_NAMEs: SARAF, ANITA  (contact)

PROGRAM_OFFICER_NAME: WEBB, STEPHANIE JOHNSON

PROJECT_TERMS: Adult;Animal Model;Architecture;Arrhythmia;Award;Basic Science;Biological Markers;Biomedical Engineering;Calcium;Cardiac;Cardiac Myocytes;cardiogenesis;Cardiomyopathies;cardioprotection;career development;Cellular Stress;Chronic;Clustered Regularly Interspaced Short Palindromic Repeats;college;Common Ventricle;Complex;congenital heart abnormality;Congenital Heart Defects;cytokine;Data;Death Rate;Development;Development Plans;Doctor of Philosophy;Engineering;Etiology;Evaluation;experience;Exposure to;Face;Fellowship;Future;gene editing technology;Genes;Goals;Heart;Heart failure;human induced pluripotent stem cells;Hypoplastic Left Heart Syndrome;in vivo;Incidence;induced pluripotent stem cell;induced pluripotent stem cell derived cardiomyocytes;Inflammation;Inflammatory;Interleukin-6;Leadership;Left;Life;Medical;medical schools;Medicine;meetings;Mentors;Mentorship;Mitochondria;Modeling;Molecular;Morbidity - disease rate;mortality;Mutation;Myocardial;Myocardial dysfunction;new therapeutic target;NOTCH1 gene;Pathologic;Pathway interactions;patient derived induced pluripotent stem cells;Patients;Pattern;Physicians;Physiologic intraventricular pressure;Physiology;Population;Positioning Attribute;preclinical study;pressure;Principal Investigator;professor;Proteins;Publications;Reactive Oxygen Species;Research;Research Training;Residencies;Rice;Role;Scientist;Signal Transduction;skills;Stress;systemic inflammatory response;tenure track;Therapeutic Intervention;timeline;TNF gene;tool;Training;Training Programs;Translational Research;Universities;Ventricular

PROJECT_TITLE: Molecular and Functional Evaluation of NOTCH1 Deficient iPSC Derived Cardiomyocytes in Hypoplastic Left Heart Syndrome

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(OA)]


NIH_SPENDING_CATS: Biotechnology

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

PHR: PROJECT NARRATIVE This grant application describes broadly based biophysical characterization of two important aspects of bacterial cell physiology. First, we will investigate the macroeconomic principles of proteome allocation by bacteria in response to different environmental challenges. Second, we will investigate the assembly of bacterial ribosomes, which is a key cellular process to produce the macromolecular machine that synthesizes all proteins in the cell.

PI_NAMEs: WILLIAMSON, JAMES R (contact)

PROGRAM_OFFICER_NAME: CZAPLINSKI, KEVIN

PROJECT_TERMS: Applications Grants;Bacteria;Bacterial Proteins;biophysical properties;Budgets;Cell Physiology;Cells;Complex;Cryo-electron tomography;Economics;Electron Microscopy;Escherichia coli;fitness;Fluorescence;Fluorescence Microscopy;Goals;Growth;In Vitro;Individual;light microscopy;Mass Spectrum Analysis;Measurement;Modeling;Monitor;Nutrient;Pathway interactions;Process;Protein Biosynthesis;protein degradation;Proteins;Proteome;response;Ribosomes;single molecule;Structure

PROJECT_TITLE: Dynamics of the Bacterial Ribosome and Proteome

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-K(55)R]


NIH_SPENDING_CATS: Neurosciences

ORG_CITY: GRAND RAPIDS

ORG_NAME: VAN ANDEL RESEARCH INSTITUTE

ORG_STATE: MI

PHR: PROJECT NARRATIVE Calcium homeostasis modulators (CALHMs) constitute a family of nonselective ion channels that are permeable to the signaling molecules calcium and ATP; they are thus critically involved in calcium and purinergic signaling. The proposed study focuses on uncovering the oligomeric state, multichannel assembly, molecular structure, gating mechanism, and pharmacology of the CALHMs, taking advantage of single- particle cryo-EM, electrophysiology, and other functional approaches. The proposed research is relevant to public health and NIH's mission because this work will provide a deep understanding and broaden our knowledge of the relationships between atomic structures and the complex biological and pathological functions of CALHMs, paving the way for the development of therapeutics to treat neurological diseases including Alzheimer disease, ischemic brain damage, and depression.

PI_NAMEs: LU, WEI  (contact)

PROGRAM_OFFICER_NAME: UMANAH, GEORGE KWABENA ESSIEN

PROJECT_TERMS: Adenosine Triphosphate;Alzheimer's Disease;Anions;antagonist;Architecture;Behavior;Binding;Binding Sites;Biochemical;Biochemistry;Biological;Biological Assay;Brain;Calcium;Cells;Chemosensitization;Complex;Connexins;Consensus;Cryoelectron Microscopy;Data;density;Dependence;Detergents;Development;Dyes;Electrophysiology (science);Environment;Exocytosis;experimental study;extracellular;Family;Family member;family structure;Foundations;Gap Junctions;GD3 Binding;Hearing;Homeostasis;Human;In Vitro;in vivo;Inflammation;insight;Ion Channel;Ions;Ischemic Brain Injury;Knowledge;Ligand Binding;Link;Lipids;Mediating;member;Membrane;Mental Depression;Methods;Mission;Molecular;Molecular Conformation;Molecular Structure;Mutagenesis;mutant;Mutate;Mutation;N-terminal;Nervous System;Nervous System Disorder;Nervous System Physiology;Neurodegenerative Disorders;neuronal excitability;neuroprotection;neurotransmission;Nociception;novel therapeutics;particle;patch clamp;Pathologic;Permeability;pharmacologic;Pharmacology;Physiology;Play;Polymers;preservation;Process;Property;Public Health;Publishing;receptor;Reporting;Research;Role;Ruthenium Red;sensor;Signal Pathway;Signal Transduction;Signaling Molecule;Site;small molecule;Solid;stoichiometry;Structure;Synapses;Synaptic Cleft;Synaptic Transmission;Taste Buds;Taste Perception;Therapeutic Agents;therapeutic development;therapeutic target;United States National Institutes of Health;voltage;Work

PROJECT_TITLE: Structural and functional studies of CALHM channels

STUDY_SECTION: BPNS

STUDY_SECTION_NAME: Biophysics of Neural Systems Study Section[BPNS]


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Neurosciences;Pain Research;Prevention;Rehabilitation;Suicide;Suicide Prevention

ORG_CITY: SYRACUSE

ORG_NAME: VETERANS HEALTH RESEARCH INSTITUTE OF CENTRAL NEW YORK, INC.

PHR: Military veterans are more vulnerable to experience chronic pain, experience psychiatric disorders, and die by suicide; however, extant research has yet to examine interventions to address suicide risk and functional impairment from chronic pain within the same intervention. Mindfulness-based cognitive therapy has demonstrated promise for individuals experiencing chronic pain and for individuals at risk for suicide, individually, but no study has combined these treatments for more robust effects on each of these outcomes. Therefore, we plan to develop a manual to address both functional impairment and suicide risk then assess its feasibility, acceptability, and parameters on key functioning outcomes.

PI_NAMEs: ASHRAFIOUN, LISHAM  (contact)

PROGRAM_OFFICER_NAME: MURRAY, PETER DANIEL

PROJECT_TERMS: acceptability and feasibility;Accounting;Address;Adherence;Aftercare;Cause of Death;chronic pain;Clinical Trials;Combined Modality Therapy;Consensus;Data;design;Development;Diagnostic Factor;Education;efficacy trial;Elements;evidence base;experience;Feasibility Studies;Feeling suicidal;follow-up;Functional impairment;functional improvement;Goals;Grant;ideation;Individual;innovation;Intervention;Manuals;Mental Depression;Mental disorders;Meta-Analysis;Methods;military veteran;Mind-Body Intervention;mind/body;mindfulness based cognitive therapy;mindfulness intervention;National Center for Complementary and Integrative Health;neural;non-opioid analgesic;novel;Opioid;opioid use;Outcome;Outcome Measure;Overdose;Pain;pain catastrophizing;Pain intensity;Pain interference;Pain management;Pain Measurement;pain outcome;Participant;Patients;Phase;Premature Mortality;Process;programs;Protocols documentation;psychologic;Public Health;Quality of life;Randomized;randomized, clinical trials;recruit;reducing suicide;Reporting;Research;Research Design;Research Priority;response;Risk;Risk Factors;Sampling;satisfaction;Severities;suicidal;suicidal behavior;suicidal risk;Suicide;Testing;Therapeutic Intervention;Thinking;treatment duration;Treatment Efficacy;United States;Veterans;Vulnerable Populations

PROJECT_TITLE: Using mindfulness-based cognitive therapy to manage pain and mitigate suicide risk in Veterans


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Biotechnology;Mental Health

ORG_NAME: SPECTRAGENETICS

PHR: Project Narrative. Our goal is to develop and commercialize an automated system that interrogates microarrays of reverse-transfected mammalian cells to detect and quantify GPCR responses to agonists, inverse agonists, and other classes of ligand. By enabling screening against large numbers of human GPCRs in parallel, the system will dramatically expand the scope of GPCR drug discovery and development projects without expanding their costs, and thus lead to new therapeutic treatments for neurological and mental diseases and conditions.

PI_NAMEs: ASBURY, G. REID  (contact)

PROGRAM_OFFICER_NAME: ANDERSON, PAIGE MARIE

PROJECT_TERMS: Address;Agonist;Archives;assay development;Automation;Basic Science;Biological;Biological Assay;Cell Line;Cells;Chemicals;chemokine receptor;Cloning Vectors;commercialization;Computer software;cost;desensitization;detection platform;Development;Disease;DNA;drug development;drug discovery;Drug Screening;expression vector;Feedback;G-Protein-Coupled Receptors;Goals;graphical user interface;Human;improved;Lead;Libraries;Ligands;Lipids;Mammalian Cell;miniaturize;Neurologic;novel therapeutics;Nucleosides;Output;Pattern;peptide B;Peptide Receptor;Phase;Printing;Psyche structure;receptor;Receptor Down-Regulation;receptor downregulation;response;screening;Signal Transduction;Site;Spottings;Surface;System;Testing;Therapeutic;tool;Transfection;user-friendly;vector

PROJECT_TITLE: Highly Multiplexed Cell-Based GPCR Assay.


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Brain Disorders;Drug Abuse (NIDA only);Methamphetamine;Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: PORTLAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

PHR: Project Narrative High initial sensitivity to aversive drug effects is likely to result in drug avoidance and reduce the probability of addiction. The study of mechanisms associated with high initial sensitivity to aversive drug effects could provide new therapeutic targets for intervention. By identifying and mapping functional circuits regulating drug aversion, we will gain new insight into how aversion-modulating systems are recruited in drug avoiding populations.

PI_NAMEs: RIOS, SAMANTHA  (contact)

PROGRAM_OFFICER_NAME: FALCON-MORALES, EDGARDO

PROJECT_TERMS: 18 year old;Acute;addiction;Adult;Animal Model;Antibodies;attenuation;Aversive Stimulus;Behavior;behavior test;Behavioral Genetics;Bilateral;Breeding;career;Cells;Cementation;Complement;conditioning;Data;data dissemination;design;designer receptors exclusively activated by designer drugs;Development;Dorsal;drinking;Electrophysiology (science);Exhibits;experience;Experimental Designs;extracellular;gamma-Aminobutyric Acid;Genetic;Genetic Models;Glutamates;Goals;Habenula;Health;improved;insight;Intake;Interneurons;Intervention;Lateral;Learning;Maps;Measures;Mediating;Mentors;Methamphetamine;methamphetamine effect;methamphetamine exposure;methamphetamine use;Methamphetamine use disorder;Mus;Neurons;new therapeutic target;Optics;optogenetics;Oregon;Other Genetics;patch clamp;Perception;Pharmaceutical Preparations;Play;Population;Preparation;Probability;recruit;regional difference;Reporting;Reproducibility;Research;Research Personnel;Resources;response;Rewards;Risk;Risk Reduction;Role;Science;Scientist;Serotonin;Signal Transduction;skills;Slice;Stimulus;Structure;Synapses;System;Testing;tool;Tracer;Training;transmission process;Universities;Viral;Writing

PROJECT_TITLE: Role of Lateral Habenula- Dorsal Raphe Circuit on MA-Induced Aversion


NIH_SPENDING_CATS: Autoimmune Disease;Behavioral and Social Science;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Diabetes;Health Services;Pediatric;Prevention

ORG_CITY: HANOVER

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: Project Narrative This project addresses a key public health issue with broad applicability to many diseases and health behaviors: how to help people follow a complicated medical regimen and achieve better health outcomes. We will test the role of coaching support focused on problem solving and incentives to help young adults with type 1 diabetes feel better and be healthier. We expect that the things we learn about helping young adults with type 1 diabetes will apply to many other health problems.

PI_NAMEs: CATHERINE STANGER, CATHERINE STANGER CATHERINE STANGER (contact)

PROGRAM_OFFICER_NAME: CENTER, MAUREEN MONAGHAN

PROJECT_TERMS: Achievement;Address;Adherence;Adolescent;Aftercare;Age;age group;age related;Algorithms;Behavior;care systems;Chronic Disease;Clinic;Clinical;clinical care;Collection;comparison intervention;Complex;Data;design;Devices;Diabetes Mellitus;digital;digital health;Disease;economic cost;Educational process of instructing;effectiveness study;efficacy testing;empowerment;Ensure;experimental study;Feedback;financial incentive;Future;glucose monitor;glycemic control;Goals;Health;Health behavior;health care service utilization;Healthcare Systems;high risk;improved;improved outcome;Incentives;Incidence;Informal Social Control;Injections;innovation;Insulin;Insulin Infusion Systems;Insulin-Dependent Diabetes Mellitus;Internet;Intervention;intervention delivery;Intervention Studies;Learning;Mediation;Medical;medical complication;meetings;Mental Depression;Methods;model design;Modeling;Monitor;mortality;multiphase optimization strategy;novel;open source;Outcome;outcome prediction;Participant;Patient Recruitments;Patients;Persons;pilot test;Play;Population;Populations at Risk;primary outcome;Problem Solving;Public Health;Randomized;Randomized, Controlled Trials;recruit;Regimen;Retrieval;Role;Self Efficacy;Self Management;Series;sex;skills;social media;Technology;Testing;therapy design;Thinking;traditional care;Transcend;treatment as usual;young adult

PROJECT_TITLE: Thinking Outside the Clinic: A Digital Health Approach for Young Adults with Type 1 Diabetes

STUDY_SECTION: PRDP

STUDY_SECTION_NAME: Psychosocial Risk and Disease Prevention Study Section[PRDP]


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Patient Safety;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: BIRMINGHAM

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: This proposal will ensure that the NCTN Program is provided access to UAB CCC clinical and translational investigators with a broad interest in cancer biology and experimental therapeutics. Importantly, this proposal will also provide NCTN clinical trials access to a patient population that based upon its demographics and socioeconomic status is distinct from other areas in the country.

PI_NAMEs: LEATH, CHARLES A. (contact);MCDONALD, ANDREW M;MEHTA, AMITKUMAR N;STRINGER-REASOR, ERICA MICHELLE

PROGRAM_OFFICER_NAME: MOONEY, MARGARET M

PROJECT_TERMS: Achievement;Address;Alabama;American College of Radiology Imaging Network;anti-cancer research;Area;Arkansas;Basic Science;Cancer and Leukemia Group B;Cancer Biology;cancer care;cancer clinical trial;Cancer Control;cancer health disparity;Cancer Patient;cancer prevention;cancer risk;Clinical Cancer Center;Clinical Investigator;Clinical Research;clinical trial participant;Clinical Trials;Clinical Trials Cooperative Group;Clinical Trials Network;Communities;Community Outreach;Comprehensive Cancer Center;Cooperative Group Program;Country;Deep South;demographics;Detection;Diagnosis;Doctor of Medicine;Doctor of Philosophy;Eastern Cooperative Oncology Group;Education;Eligibility Determination;Ensure;ethnic minority;Faculty;Fostering;Funding;Gynecologic Oncology Group;Health Disparities Research;health disparity;Home;Hospitals;Infrastructure;Institution;Intention;interest;International;Intervention;Investigational Therapies;Knowledge;Lead;Leadership;Louisiana;Malignant Neoplasms;member;Mentors;Minority;minority health;minority health disparity;Minority Participation;minority scientist;Mississippi;Names;National Clinical Trials Network;National Surgical Adjuvant Breast and Bowel Project;next generation;organizational structure;Outcome;participant enrollment;patient population;Patients;Persons;Phase;Physicians;population based;Process;programs;Quality of life;racial disparity;racial minority;Radiation Therapy Oncology Group;Recording of previous events;recruit;Research;Research Personnel;Role;Scientist;Site;Socioeconomic Status;Southwest Oncology Group;survivorship;Training;Training and Infrastructure;Training Programs;Translating;Translational Research;translational scientist;treatment trial;United States;Universities;Vision;Work

PROJECT_TITLE: NCTN Deep South Research Consortium


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;Immunization;Infectious Diseases;Malaria;Malaria Vaccine;Orphan Drug;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative Worldwide, malaria kills more than 400,000 people each year, primarily children under five years of age. In this proposal, we aim to expedite the preclinical testing by creating human-like genetically engineered mouse models and using them to validate potential vaccine candidates.

PI_NAMEs: BATISTA, FACUNDO DAMIAN (contact)

PROGRAM_OFFICER_NAME: MO, ANNIE X  Y

PROJECT_TERMS: 5 year old;Acceleration;Affinity;Animal Model;Anti-malarial drug resistance;Antibodies;Antigens;Automobile Driving;B-Cell Activation;B-Cell Antigen Receptor;B-Lymphocytes;candidate validation;Cell Separation;Cells;Cessation of life;Child;circumsporozoite protein;Clinical;Clinical Trials;Communities;Custom;Data;Development;Drug Controls;Engineering;Epitopes;Erythrocytes;Etiology;Evaluation;experimental study;Frequencies;Generations;Genetically Engineered Mouse;Germ Lines;global health;Goals;Growth;Health Priorities;HIV-2;Human;humanized mouse;Humoral Immunities;Immune;Immune response;Immunization;immunogenicity;Immunoglobulin Somatic Hypermutation;improved;in vivo;Infection;innovation;Insecticides;Knock-in;Knock-in Mouse;Length;Malaria;Malaria Vaccines;Modeling;Monoclonal Antibodies;mortality;mouse model;Mus;novel;Pathway interactions;Peptides;Persons;Physiological;Plasmodium falciparum;pre-clinical;Preclinical Testing;prevent;protective allele;Protein Region;Proteins;Resources;response;screening;Series;single cell sequencing;Site;Sporozoites;Structure of germinal center of lymph node;success;Surface;technological innovation;Therapeutic;Time;Titrations;tool;vaccination strategy;vaccine candidate;Vaccine Design;vaccine evaluation;vaccine immunogenicity;Vaccine Research;Vaccines;Validation;Variant;vector control

PROJECT_TITLE: Accelerating Malaria Vaccines with a Custom Preclinical Humanized Mouse Model Platform

STUDY_SECTION: VMD

STUDY_SECTION_NAME: Vaccines Against Microbial Diseases Study Section[VMD]


NIH_SPENDING_CATS: Autoimmune Disease;Digestive Diseases;Inflammatory Bowel Disease;Nutrition;Prevention;Regenerative Medicine

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: Project Narrative: Dietary lipids are known to amplify inflammatory responses in chronic inflammatory diseases, which are associated with defective tissue repair processes. Although it is known that diets high in fat exacerbate inflammatory conditions such as inflammatory bowel disease (IBD), it is unclear how dietary lipids impact the intestinal immune system and tissue repair. Understanding how environmental components, such as diet, can induce or amplify inflammatory immune cell functions that support loss of tissue resolution will open the door to novel treatments for IBD and other inflammatory conditions.

PI_NAMEs: MCALESTER, ANDREA ALYSSA (contact)

PROGRAM_OFFICER_NAME: SASLOWSKY, DAVID E

PROJECT_TERMS: Animals;Anti-Inflammatory Agents;Apoptotic;Atherosclerosis;Autoimmune;Autoimmune Diseases;Biological Assay;Body Weight decreased;Cardiovascular Diseases;CD36 gene;Cell Physiology;Cells;Chronic;chronic inflammatory disease;Chronic Obstructive Pulmonary Disease;Clinical;Colitis;cytokine;Cytoprotection;Data;Defect;Development;Diet;Dietary Component;Dietary Fats;Disease;effective therapy;Environment;Environmental Risk Factor;Epithelial Cell Proliferation;Epithelial Cells;epithelial repair;Epithelium;Fatty acid glycerol esters;feeding;food consumption;Functional disorder;Goblet Cells;gut inflammation;gut microbiota;healing;Health;High Fat Diet;Immune;immune function;Immune response;Immune system;Impairment;In Vitro;in vivo;Incidence;Individual;Infection;Inflammation;Inflammatory;Inflammatory Bowel Diseases;Inflammatory Response;Ingestion;Inhalation;insight;Insulin-Dependent Diabetes Mellitus;Intercellular Junctions;interest;Interleukin-10;intestinal barrier;Intestinal Diseases;intestinal epithelium;intestinal homeostasis;intestinal injury;Intestines;Link;Lipids;Lupus;Macrophage;Mediating;Microbe;microbial;Molecular;mouse model;Mus;neutrophil;novel;pathogen;Pathogenesis;Pathology;Pathway interactions;Penetration;Phase;Physiology;Predisposition;prevent;Process;Production;Proliferating;Proteins;receptor;Regulation;repair function;repaired;Resolution;response;Role;Severities;Signal Pathway;Signal Transduction;Stimulus;Support System;Symptoms;System;systemic inflammatory response;Testing;therapeutic target;Tight Junctions;Time;tissue injury;tissue repair;tissue-repair responses;Tissues;uptake;Weight Gain;wound healing

PROJECT_TITLE: Lipid dysregulation of immune mediated intestinal epithelial healing

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Cannabinoid Research;Clinical Research;Drug Abuse (NIDA only);Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Substance Misuse

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE The increasing prevalence of cannabis use has created a significant public health concern, particularly for the highest using group, young adults; however, additional research is needed to understand how to mitigate the harms associated with frequent and heavy cannabis use. The proposed study will fill an important gap in the cannabis and PBS literature by providing a foundation for future PBS interventions and potentially offering insight to why recent PBS focused interventions have yielded inconsistent results. Results from the present study will provide a measurement of daily cannabis PBS and a personalized, data-driven approach to PBS focused interventions.

PI_NAMEs: SMITH-LECAVALIER, KIRSTYN NICOLE (contact)

PROGRAM_OFFICER_NAME: LIN, YU

PROJECT_TERMS: addiction;Address;Age;Alcohol consumption;Alcohols;Algorithms;Behavior;Behavioral;Brain;Cannabis;Complement;condoms;Cross-Sectional Studies;Data;Data Collection;Data Pooling;Data Science;design;Development;DSM-IV;Education;Epidemiology;Etiology;Feedback;Focus Groups;Foundations;Frequencies;Future;Gambling;Goals;Grant;Harm Reduction;Impairment;improved;Individual;insight;interest;Intervention;Intervention Studies;Judgment;Knowledge;Learning;Legal;Literature;Machine Learning;machine learning method;machine learning model;Manuscripts;Marijuana;Marijuana Dependence;marijuana use;Measurement;Measures;Mediating;Memory;Memory impairment;Methodology;Methods;Modeling;Motor;multilevel analysis;National Institute of Drug Abuse;novel;novel strategies;Outcome;personalized approach;Persons;Phase;phase 2 study;predictive modeling;Prevalence;Prevention;Psychometrics;psychosocial outcome;Public Health;random forest;Recommendation;Reporting;Research;research data dissemination;Research Design;Research Personnel;Research Training;Resources;response;Review Literature;Risk Factors;Sampling;Sex Behavior;Social Change;substance use;Surveys;symposium;Techniques;Technology;tool;Training;undergraduate student;Validation;Work;Writing;young adult

PROJECT_TITLE: Measurement and Modeling of Within-Person Variability in Cannabis Protective Behavioral Strategies: A Novel Approach Using Scale Development, Daily Data, and Machine Learning Methods

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F16-L(20)L]


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: NARRATIVE The proposed research is relevant to public health because hospitals remain unaware of many existing patient safety threats due to their over-reliance on flawed voluntary incident reporting. By demonstrating the effectiveness of a coproduced (created in partnership with families), equity-focused, multicomponent communication intervention to engage patients and families in hospital safety reporting, our study will (1) provide a framework for hospitals to overcome the current limitations of voluntary incident reporting and (2) identify unrecognized areas to improve safety, particularly for vulnerable patients. Genuine coproduction with patients and families will open new strategic approaches to improving the safety, quality, and equity of healthcare, in line with AHRQ's mission.

PI_NAMEs: KHAN, ALISA  (contact)

PROGRAM_OFFICER_NAME: FREEMAN, WILLIAM

PROJECT_TITLE: A Multicenter Randomized Controlled Trial of a Patient Safety Reporting Intervention for Families to Improve Medical Error Detection and Reduce Inequities

STUDY_SECTION: HSQR

STUDY_SECTION_NAME: Healthcare Patient Safety and Quality Improvement Research[HSQR]


ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Narrative Interventions to decrease venous thromboembolism (VTE), a leading cause of preventable harm, have focused on improving prescription of prophylaxis for hospitalized patients; however, VTE prophylaxis medication nonadherence is an enormous and largely unrecognized problem in hospitals across the country. We will deliver interactive, online, scenario-based education to all frontline nurses at our participating hospitals (SA1) regarding the importance of VTE prevention for hospitalized patients. We will scale up a successful patient- centered, evidence-based education bundle intervention using real-time electronic health record data for hospitalized patients who missed doses of VTE prophylaxis medication (SA2) and assess satisfaction about the quality of nurse-patient communication regarding prescribed medication (SA3). The goal of this project is to empower patients to make informed evidence-based decisions about their VTE preventive care and improve VTE prophylaxis medication adherence among patients hospitalized in heterogeneous environments.

PI_NAMEs: LAU, BRANDYN DANIEL (contact)

PROGRAM_OFFICER_NAME: HAUGSTETTER, MONIKA

PROJECT_TITLE: Disseminating a Patient Centered Venous Thromboembolism Prevention Bundle


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Mental Illness;Neurosciences

ORG_CITY: MINNEAPOLIS

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF MINNESOTA

PHR: Project Narrative: Depression and anxiety-related disorders are highly prevalent, debilitating, and are often linked to abnormal stress processing. The stress-associated neurotransmitter corticotropin releasing factor (CRF) is widely distributed throughout the central and peripheral nervous system. This proposal posits that chronic stress shifts CRF responsivity and CRF modulation of behavior in a way that propels individuals to a state of negative perceptual bias and withdrawal from their environment and contends that this shift is key to understanding vulnerability to diseases such as depression and anxiety.

PI_NAMEs: LEMOS, JULIA C (contact)

PROGRAM_OFFICER_NAME: BREEDEN, ANDREW LEE

PROJECT_TERMS: 3-Dimensional;Acute;acute stress;Affective;Anxiety;anxiety-related disorders;approach behavior;approach/avoidance behavior;avoidance behavior;Award;Behavior;behavioral outcome;behavioral response;biobehavior;biological adaptation to stress;Brain;brain control;brain pathway;Brain region;calcium indicator;Cell Nucleus;cell type;Cells;Central Nervous System;Chronic stress;Corpus striatum structure;Corticotropin-Releasing Hormone;Depressed mood;Disease;dopaminergic neuron;dorsal raphe nucleus;Environment;experience;experimental study;Female;Fiber;Genetic;Genetic Recombination;Glutamates;high risk;hypothalamic-pituitary-adrenal axis;Imaging Techniques;In Situ Hybridization;in vivo calcium imaging;Individual;innovation;Investigation;Knock-out;life history;Light;Link;male;Maps;Mediating;Mental Depression;Microscopy;Mus;National Institute of Mental Health;Nature;Negative Valence;neural;Neuroanatomy;neurochemistry;Neuromodulator;Neurons;Neuropeptides;neuropsychiatric disorder;Neurotransmitters;novel;optogenetics;particle;Pathologic;Pathway interactions;Pattern;Peptides;Peripheral Nervous System;Photometry;Population;Positive Valence;Process;programs;Regulation;release factor;Reporter;Research;Research Personnel;Research Project Grants;response;Scientist;Site;Stimulus;Stress;stress state;stressor;success;System;Techniques;Technology;Testing;Therapeutic;tool;Transgenic Organisms;Viral;Vision;wireless;Withdrawal;Work

PROJECT_TITLE: Determining the unique and dynamic neural constellation belonging to acute and chronic stress states