NIH_SPENDING_CATS: Cancer;Orphan Drug;Rare Diseases

ORG_CITY: DETROIT

ORG_NAME: WAYNE STATE UNIVERSITY

PHR: PROJECT NARRATIVE In this application, we explore the unique biology of the facilitative folate transporters and the role of one- carbon (C1) metabolism in cancer, with a goal of further optimizing therapeutic applications of novel targeted anti-tumor agents. The project explores therapeutic applications of the human proton-coupled folate transporter (PCFT) which occurs in many tumors and is functionally and anatomically distinct from the ubiquitous reduced folate carrier, the major tissue folate transporter. Additional focus is on essential C1 metabolic pathways that are compartmentalized and are differentially expressed in tumor cells versus normal cells as they contribute to cancer etiology and progression. Our proposed studies provide a necessary prelude for the design of a new generation of therapeutics for cancer, and how therapeutic benefit can be maximized for our novel agents, drawing from the remarkably complex physiology of tumor cells.

PI_NAMEs: HOU, ZHANJUN ;MATHERLY, LARRY H (contact)

PROGRAM_OFFICER_NAME: GREENBERG, WILLIAM A

PROJECT_TERMS: absorption;Acids;Alimta;Anabolism;Anatomy;Anions;anti-tumor agent;anti-tumor drug;Antineoplastic Agents;autosome;Biological;Biology;Cancer Etiology;Carbon;Cell Line;Cell membrane;Cell Survival;Cells;Circulation;Clinical;clinical translation;Complex;Coupled;Cytosol;cytotoxic;design;differential expression;Diffusion;Disease;Drug resistance;Epithelial Cells;Epithelial ovarian cancer;Epithelium;folate-binding protein;Folic Acid;Folic Acid Antagonists;Folic Acid Deficiency;Formates;FRAP1 gene;Generations;Genetic Transcription;Glutathione;Glycine;glycine amide;Glycine Hydroxymethyltransferase;Goals;Grant;hereditary folate malabsorption;Human;Human Biology;human disease;hydrophilicity;Hydroxymethyltransferases;Hypoxia;Immunohistochemistry;in vivo;inhibitor;Leukemic Cell;Lung Adenocarcinoma;Malabsorption Syndromes;Malignant Neoplasms;Malignant Pleural Mesothelioma;Mammalian Cell;Mediating;Membrane;Membrane Transport Proteins;Metabolic Pathway;Metabolism;Methionine;Methotrexate;Mitochondria;Molecular;Mutation;neoplastic cell;Normal Cell;novel;novel strategies;novel therapeutics;Orphan Drugs;Ovarian;Pancreas;Pancreatic Adenocarcinoma;Pathway interactions;Patients;Pemetrexed;Pharmacodynamics;Physiological;Physiology;protein protein interaction;Protons;Publishing;Purine Nucleotides;Purines;Raltitrexed;Reactive Oxygen Species;Regulation;Reporting;Research;Resistance;Ribonucleotides;Role;Series;Serine;Signal Transduction;SLC19A1 gene;Specimen;Structure-Activity Relationship;System;targeted agent;targeted treatment;Tetrahydrofolates;Therapeutic;thymidylate;Time;Tissues;tumor;Tumor Cell Line;tumor microenvironment;tumor progression;Tumor stage;tumor xenograft;Upper digestive tract structure;uptake

PROJECT_TITLE: Molecular Regulation of Folate and Antifolate Transport


ADMINISTERING_IC: HD

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Brain Disorders;Cerebrovascular;Childhood Injury;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Infectious Diseases;Intellectual and Developmental Disabilities (IDD);Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Stroke;Unintentional Childhood Injury;Women's Health Research

ORG_CITY: SAN FRANCISCO

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PEDIATRICS

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE Hypoxic-ischemic encephalopathy (HIE) occurs when a newborn baby gets reduced oxygen and blood flow to the brain and can lead to death or long-term disabilities such as cerebral palsy. The causes of HIE are poorly understood. This study will determine whether placental infection or inflammation (chorioamnionitis) can cause HIE, and whether the signs of chorioamnionitis are linked to more severe brain injury in infants with HIE.

PI_NAMEs: CORNET, MARIE  (contact)

PROGRAM_OFFICER_NAME: GUMINA, DIANE LAURA

PROJECT_TERMS: Accounting;administrative database;Affect;Animal Model;autism spectrum disorder;Award;Azithromycin;Biometry;Birth;Blood;Blood flow;Brain;Brain Diseases;Brain Hypoxia-Ischemia;Brain imaging;Brain Injuries;brain magnetic resonance imaging;California;career;Cell Count;Cerebral Palsy;Cessation of life;Child;Childhood;Clinical;clinical diagnosis;cohort;Consensus;Data;Data Analyses;data management;demographics;Development;Diagnosis;Early treatment;electronic health data;electronic health record system;Epidemiologist;Epidemiology;Epidural Analgesia;Epilepsy;Etiology;Exhibits;Exposure to;fetal;fetal inflammatory response syndrome;Fetus;Fever;Future;Height;high risk;Histologic;Histology;Human Development;improved;Infant;infant brain injury;Inflammation;Inflammatory Response;Intellectual functioning disability;intraamniotic infection;intrauterine infection;intrauterine inflammation;Knowledge;Leukocytes;Leukocytosis;Link;Long term disability;Magnetic Resonance Imaging;Mediating;Melatonin;Mentorship;Mission;Mothers;National Institute of Child Health and Human Development;natural hypothermia;Neonatal;neonatal brain;neonatal hypoxic-ischemic brain injury;neonate;Neurodevelopmental Disability;Neurodevelopmental Impairment;Neurologic;Neurology;neuroprotection;Newborn Infant;novel;novel strategies;Outcome;Outcome Study;Oxygen;Pathologist;Perinatal;Physicians;Placenta;placental infection;Pregnancy;prevent;Recommendation;Reporting;Research Personnel;Risk;Risk Factors;Scientist;Services;Severities;skills;Syndrome;System;Tachycardia;targeted therapy trials;targeted treatment;Temperature;Term Birth;Testing;Therapeutic;Therapeutic Effect;therapeutic effectiveness;Therapy Clinical Trials;Training;Training Programs;Treatment Efficacy;United States

PROJECT_TITLE: Maternal Chorioamnionitis and Hypoxic-Ischemic Encephalopathy: The MATCH Study

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Pediatrics Study Section[CHHD-A]


ADMINISTERING_IC: GM

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Advances in genomic technology are transforming medicine, but there are too few physicians training in medical genetics today. This program will provide training in medical genetics and genetics research to physician scientists, to grow the genetics workforce in the four areas where science is progressing the fastest: cancer, rare diseases, gene-environment interactions, and neurodegeneration.

PI_NAMEs: DICKSON, PATRICIA I (contact)

PROGRAM_OFFICER_NAME: AKACEM, LAMEESE DANA

PROJECT_TERMS: Genomic medicine;post-doctoral training;Training Programs

PROJECT_TITLE: Postdoctoral Training Program in Genomic Medicine


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: Project Narrative: This training grant, which is in its 45th year, provides NIH funds to the Cardiology Division at the Massachusetts General Hospital to train the next generation of scientists in cardiovascular research. Our training program continues to have an excellent track record of training scientists who remain in academia/research and go on to become leaders in their chosen research fields.

PI_NAMEs: ELLINOR, PATRICK THOMAS;SOSNOVIK, DAVID E (contact);YU, PAUL B

PROGRAM_OFFICER_NAME: CHEON, YEWON

PROJECT_TITLE: Integrated, Multidisciplinary Training in Cardiovascular Research

STUDY_SECTION: NITM

STUDY_SECTION_NAME: NHLBI Institutional Training Mechanism Study Section[NITM(JA)]


ADMINISTERING_IC: DK

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Genetics;Hematology;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: NEW YORK

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: NARRATIVE  This proposal focuses on a continuing investigation of the EKLF/KLF1 transcription factor and how it coordinates erythroid cell-specific control of gene transcription, metabolism, and epigenetics. Extensive use is being made of primary cells and of analyzing mouse and human mutations that lead to anemia in vivo.

PI_NAMEs: BIEKER, JAMES J (contact)

PROGRAM_OFFICER_NAME: ROY, CINDY

PROJECT_TERMS: Acetylation;Acylation;Address;Adult;Affect;Anemia;Arginine;ascorbate;ATAC-seq;beta Globin;beta-Hydroxybutyrate;Biochemical;Biological Process;Biology;Blood Cells;Butyrates;Carnitine;Cell Line;Cells;Chromatin;Chromatin Structure;Collaborations;Consultations;Data;DNA;DNA metabolism;Enzymes;Epigenetic Process;Erythroid;Erythroid Cells;erythroid Kruppel-like factor;Erythropoiesis;Event;experimental study;Fetal Hemoglobin;follow-up;Funding;Gene Activation;Gene Expression Regulation;Genes;Genetic;genetic approach;Genetic Models;Genetic Transcription;Hand;Hematopoiesis;Heterozygote;Histone Deacetylase Inhibitor;histone modification;Histones;Human;Human Cell Line;in vivo;induced pluripotent stem cell;innovation;interest;Investigation;Letters;Link;Longitudinal Studies;Maps;Metabolic;Metabolism;metabolome;metabolomics;Methodology;Modeling;Modification;Molecular;Mus;mutant;Mutation;Nature;novel;patient derived induced pluripotent stem cells;Patients;Phase;Phosphorylation;Play;Post-Translational Protein Processing;Process;programs;promoter;Property;protein protein interaction;Protocols documentation;Reagent;Regulator Genes;Role;Series;Site;success;Sumoylation Pathway;Testing;transcription factor;Transcription Initiation;Ubiquitination

PROJECT_TITLE: Function of Putative Determinant in Hematopoiesis

STUDY_SECTION: BBHV

STUDY_SECTION_NAME: Basic Biology of Blood, Heart and Vasculature Study Section [BBHV]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

ORG_CITY: CAMBRIDGE

ORG_NAME: BROAD INSTITUTE, INC.

PHR: PROJECT NARRATIVE The human genome contains genes that code for the protein machines in cells, as well as millions of regulatory switches that control when, where and how much protein is made. Mutations that alter these regulatory switches underlie a wide range of cardiovascular, metabolic, autoimmune, neuropsychiatric and neurodegenerative diseases. This project will assemble a comprehensive public resource of these regulatory switches and the genes that they control, with the long-term goal to advance human genomics research and personalized medicine.

PI_NAMEs: BERNSTEIN, BRADLEY EVAN;BUENROSTRO, JASON DANIEL (contact)

PROGRAM_OFFICER_NAME: MORRIS, STEPHANIE A

PROJECT_TERMS: Affect;Antibodies;Autoimmune Diseases;Bar Codes;Binding;Binding Sites;Biological Assay;Biology;Blood;Brain;Cadaver;Cardiovascular Diseases;Cardiovascular system;Cell model;Cell Nucleus;cell type;Cells;Cellular Assay;Chromatin;Classification;Code;cohort;Collaborations;Collection;Communities;computerized tools;Consent;Consultations;cost effective;Data;data integration;Data Set;design;Development;Disease;DNA;Elements;Endocrine;Enhancers;ethnic diversity;Event;experience;Experimental Models;gastrointestinal;Gene Expression;Gene Expression Profile;gene interaction;Gene Targeting;Genes;Genetic;genetic variant;Genetic Variation;genome-wide;Genomic medicine;genomic variation;Genomics;Genotype;Goals;Harvest;histone modification;Human;human disease;Human Genetics;Human Genome;human genomics;human model;human tissue;Immune;induced pluripotent stem cell;innovation;Maps;Metabolic;Metabolic Diseases;Microglia;Modeling;Modification;multiple omics;Mutation;nerve stem cell;Neurodegenerative Disorders;Neurons;neuropsychiatric disorder;Operative Surgical Procedures;Organoids;Peripheral Blood Mononuclear Cell;personalized medicine;Phenotype;Physiological;Process;Production;promoter;Proteins;Quantitative Trait Loci;Recovery of Function;Regulatory Element;Research;Research Personnel;Resolution;Resources;response;Risk;RNA;Sampling;single-cell RNA sequencing;Specificity;Specimen;Standardization;Technology;Tissue Model;Tissues;trait;Transcript;transcription factor;Transposase;Untranslated RNA;Variant;Work

PROJECT_TITLE: A Foundational Resource of Functional Elements, TF footprints and Gene Regulatory Interactions


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Prevention;Rare Diseases;Vector-Borne Diseases

ORG_CITY: BERKELEY

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: NARRATIVE Recent pandemics have demonstrated the capacity of human pathogens to rapidly emerge to cause widespread outbreaks with new, and potentially severe clinical outcomes, emphasizing the urgent need to put in place flexible and coordinated systems that can quickly respond to the emergence of new pathogens in any region and provide high-quality clinical data and specimens for multidisciplinary research efforts. The overarching goal of this proposal is to develop an interconnected, harmonized network of clinical and laboratory sites in Ecuador, Nicaragua, and Sri Lanka to provide the foundation for research programs at individual locations, compare arboviral diseases across geographic regions, develop and implement cutting-edge molecular and serological testing methods, and respond efficiently and effectively to new disease outbreaks. This Asian and American Centers for Arbovirus Research and Enhanced Surveillance (A2CARES) Consortium will provide valuable new tools, knowledge and sites to the Emerging Infectious Disease Research Center (EIDRC) Network.

PI_NAMEs: COLOMA, JOSEFINA ;HARRIS, EVA  (contact)

PROGRAM_OFFICER_NAME: WOODSON, SARA ELAINE

PROJECT_TERMS: Address;Africa;age group;American;Americas;arboviral disease;Arboviruses;Asia;Asian;authority;Basic Science;chikungunya;Chikungunya virus;Clinical;Clinical Data;Clinical Management;Clinical Research;cohort;Cohort Studies;Collaborations;Communicable Diseases;Communities;Comparative Study;data management;Dengue;Dengue Virus;design;Detection;Development;Diagnosis;Diagnostic;Diagnostic Procedure;Diagnostic tests;Disease;Disease Outbreaks;Disparate;Ebola;Ecuador;Emerging Communicable Diseases;emerging pathogen;Epidemic;Epidemiology;Evaluation;experience;Family;flexibility;Foundations;Future;Geographic Locations;Geography;Goals;Health;Hospitalization;Hospitals;Human;human pathogen;Immunology;In Situ;Incidence;Individual;Infection;Infectious Diseases Research;Infrastructure;innovation;Interdisciplinary Study;International;Investigation;Joints;Knowledge;Laboratories;Latin America;Location;Longitudinal cohort;Measures;member;Methods;Molecular;Molecular Epidemiology;multiplex assay;National Institute of Allergy and Infectious Disease;next generation sequencing;Nicaragua;nonhuman primate;novel;novel diagnostics;Orthobunyavirus;outbreak response;Outcome;pandemic disease;pathogen;Pathogen detection;pathogenic virus;Pattern;Performance;peri-urban;Phylogenetic Analysis;programs;Publications;Readiness;Research;Research Infrastructure;Research Personnel;response;Rural;Rural Population;Sampling;Serology;Serology test;Severities;Site;Specimen;Sri Lanka;Standardization;Statistical Data Interpretation;surveillance data;Surveys;sustainability framework;System;Testing;Time;tool;Training Programs;transmission process;Urban Population;Urbanicity;vaccine development;Vaccines;vector;Viral;Viral Genome;virus testing;ZIKA;Zika Virus

PROJECT_TITLE: American and Asian Centers for Arboviral Research and Enhanced Surveillance (A2CARES)


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Assistive Technology;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_DEPT: NEUROSCIENCES

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative It is believed that spatial navigation, learning, and generalization deficits in patients with Alzheimer’s disease and Alzheimer’s disease-related dementias result from dysfunction in medial temporal lobe and frontal lobe brain structures. However, surprisingly little is known about the underlying computations that go awry in these diseases. This grant seeks to elucidate those underlying neural mechanisms by determining if/how learning spatial rules in new environments, decision-making, and generalization are supported by population-level computations across a circuit spanning the hippocampus, prefrontal cortex, and motor output pathways.

PI_NAMEs: GULLI, ROBERTO ADAMO (contact)

PROGRAM_OFFICER_NAME: ULLRICH, LAUREN ELIZABETH

PROJECT_TERMS: Address;Affect;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease related dementia;Area;Award;Behavior;behavior prediction;Biological Models;Brain;Brain region;career;Cells;Cognition;Cognitive;cognitive capacity;Coupled;Decision Making;Deep Brain Stimulation;Development;Disease;Dissociation;effective therapy;Electrophysiology (science);Environment;Etiology;Exhibits;experience;experimental study;frontal lobe;Functional disorder;Geometry;Goals;Grant;Hippocampus;improved;innovation;insight;Institution;Intervention;Joystick;Knowledge;knowledge integration;Laboratories;Laboratory Research;Learning;Link;Location;Maps;medial temporal lobe;Mediating;medical schools;Memory Disorders;Monkeys;Motor;Motor Cortex;Motor output;neural;neural circuit;neuromechanism;Neurons;neurophysiology;novel;novel therapeutics;Output;Pathway interactions;Population;Prefrontal Cortex;Process;Research Personnel;Role;Running;Scientist;sensory input;Structure;Symptoms;Testing;Time;Training;translational neuroscience;virtual;virtual environment;virtual reality;virtual reality environment;Visit;way finding

PROJECT_TITLE: Elucidating the Neural Computations Underlying Spatial Learning, Decision-Making and Generalization in Virtually-Navigating Monkeys

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-2 Study Section [NST-2]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Eye Disease and Disorders of Vision;Patient Safety;Precision Medicine;Prevention;Rare Diseases

ORG_CITY: CLEVELAND

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

ORG_STATE: OH

PHR: Project Narrative This research program addresses the need for more personalized approaches to conditions that affect the cornea, the outer layer of the eye primarily responsible for focusing images on the retina. The work combines the development of novel tools for optical mapping of a person’s unique corneal biomechanical properties and creation of patient-specific computer simulations to predict a patient’s surgical outcome or risk of disease development and progression. In addition to addressing important gaps in our understanding of corneal diseases such as keratoconus, this work is expected to produce validated models that surgeons can use to optimize an individual’s surgical plan prior to performing the actual treatment.

PI_NAMEs: DUPPS, WILLIAM JOSEPH (contact);GRYTZ, RAFAEL ;ROLLINS, ANDREW MARTIN

PROGRAM_OFFICER_NAME: GOVER, TONY DOUGLAS

PROJECT_TERMS: 3-Dimensional;Address;Affect;Agreement;Air;Anterior;Biological Markers;biomechanical test;Biomechanics;Biomedical Engineering;Blindness;Body System;Clinical;clinical development;clinical investigation;Computer Models;Computer Simulation;Cornea;Corneal Diseases;corneal surgery;crosslink;Data;Development;Diagnosis;Disease;Disease Progression;disorder risk;Early Diagnosis;elastography;Elements;Engineering;Eye;Geometry;Human;Image;in vivo;Individual;Intervention;Keratoconus;Laser In Situ Keratomileusis;Longitudinal Studies;Maps;Measurement;Measures;Methods;Modeling;multidisciplinary;Nomograms;novel;novel marker;Operative Surgical Procedures;Optics;Outcome;outcome prediction;Pathological Dilatation;Patients;personalized approach;personalized medicine;personalized predictions;Persons;Positioning Attribute;Postoperative Period;precision medicine;predictive modeling;Probability;Procedures;prognostic;programs;progression risk;Property;Refractive Errors;Relative Risks;Research;Research Project Grants;Retina;Risk;Risk Assessment;Sampling;Series;Shapes;simulation;Speed;Stress;Structural Models;Surgeon;surgery outcome;Surgical incisions;surgical risk;System;targeted imaging;Testing;three-dimensional modeling;Time;tomography;tool;Translations;treatment planning;Variant;verification and validation;viscoelasticity;Visual;visual performance;Work

PROJECT_TITLE: Advanced Imaging and Simulation Tools for Personalized Corneal Disease Assessment and Surgery

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]


NIH_SPENDING_CATS: Brain Disorders;Genetics;Intellectual and Developmental Disabilities (IDD)

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative Centrosomes are required for error-free mitosis and other cellular functions, and their deregulation drives developmental disorders, such as microcephaly and cancer. This proposal investigates novel paradigms of centrosome regulation by examining the functional consequences of mRNA localized to centrosomes.

PI_NAMEs: LERIT, DOROTHY A (contact)

PROGRAM_OFFICER_NAME: MILLER, RITA K

PROJECT_TERMS: Active Biological Transport;Acute;Adhesions;autism spectrum disorder;Biochemistry;Biology;brain size;cancer biomarkers;cell behavior;Cell Cycle;Cell division;Cell Physiology;Cell Survival;cell type;Cells;Cellular biology;Centrosome;Chromosomal Instability;cilium biogenesis;Complex;Congenital Abnormality;Coupled;Data;Developmental Delay Disorders;developmental disease;Disease;disease model;Drosophila genus;Dynein ATPase;Embryo;Engineering;fly;FMR1 gene;Foundations;Functional disorder;Future;Genetic;Genome Stability;Goals;Head;Health;Heritability;Homeostasis;Human;Image;Intellectual functioning disability;interdisciplinary approach;Interphase;Knowledge;Learning;Link;Malignant Neoplasms;Memory;Messenger RNA;Microcephaly;Microtubule-Organizing Center;Microtubules;migration;Minus End of the Microtubule;Mitosis;Mitotic spindle;Modeling;Monitor;Motor;Mutation;Neurodevelopmental Disorder;Normal Cell;novel;Paraneoplastic Cerebellar Degeneration;pericentrin;posttranscriptional;Prognostic Marker;Proliferating;Protein Biosynthesis;Proteins;recruit;Regulation;response;Ribonucleoproteins;RNA;RNA Sequences;RNA-Binding Proteins;Role;Site;spatiotemporal;Structure;Testing;trafficking;Translations;Work

PROJECT_TITLE: Post-transcriptional mechanisms of centrosome regulation

STUDY_SECTION: CSRS

STUDY_SECTION_NAME: Cellular Signaling and Regulatory Systems Study Section[CSRS]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE - OVERALL The heart is a vital organ for human health. Our in-depth characterization of this organ will lead to improved understanding of heart diseases and has the potential to greatly change the outcomes landscape of these heart diseases.

PI_NAMEs: MOFFITT, JEFFREY ;PEI, LIMING ;TAN, KAI  (contact)

PROGRAM_OFFICER_NAME: ADHIKARI, BISHOW B

PROJECT_TERMS: Adult;Age;Aging;Algorithms;Anatomy;ATAC-seq;Atlases;Automobile Driving;Awareness;Basic Science;biobank;Biological Assay;Biology;Biomedical Research;Boston;burden of illness;cardiac aging;Cell Communication;Cell Nucleus;cell type;Cells;cellular imaging;Cellular Structures;Childhood;Chromatin;Clinical Data;Clinical Research;Collaborations;Communities;Complex;complex data;Computational algorithm;computational pipelines;Computer Models;Computer software;computerized tools;Computing Methodologies;Data;Data Analyses;data sharing;Databases;Detection;Development;Diagnosis;Dimensions;Disease;Emerging Technologies;epidemiologic data;epigenomics;Ethnic Origin;Fluorescent in Situ Hybridization;Follow-Up Studies;Freezing;Genetic Transcription;genomic data;Health;Heart;Heart Diseases;Heart Research;Heterogeneity;Human;Human BioMolecular Atlas Program;human disease;human tissue;Image;Imaging technology;improved;indexing;Informed Consent;Infrastructure;Iowa;Knowledge;life span;Maps;Mediating;Medical;Methods;Molecular;molecular imaging;Molecular Profiling;multiple omics;multiplexed imaging;Normalcy;open source;Organ;Outcome;Pattern;Pediatric Hospitals;Pennsylvania;Phase;Phenotype;Philadelphia;Physiological;Population;precision medicine;Production;Prognosis;Proteins;Proteomics;Protocols documentation;Regulatory Pathway;Research;Research Personnel;RNA;searchable database;sex;Signal Pathway;Signal Transduction Pathway;single cell analysis;Small Nuclear RNA;Spatial Distribution;Specimen;Techniques;Technology;Tissue Donors;tissue mapping;Tissue Preservation;Tissue Procurements;Tissues;transcriptomics;Translational Research;Universities;user-friendly;Visualization

PROJECT_TITLE: Center for multidimensional atlas of the human heart


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Asthma;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Effects of Indoor Air Pollution;Lung;Pediatric;Social Determinants of Health

PHR: NARRATIVE Mold contamination is common in urban homes, disproportionately affects lower-income families who have less control over conditions that cause mold growth and has been clearly linked to increased asthma exacerbations. This project will test the impact on asthma morbidity in adults in children of an innovative mold remediation program being conducted in the largest public housing system in the United States, the New York City Housing Authority, which has more than 365,000 residents. If successful, we will demonstrate the utility of this large-scale public health intervention on asthma morbidity among low-income NYC residents, a community with a high burden of asthma morbidity.

PI_NAMEs: PERZANOWSKI, MATTHEW S (contact)

PROGRAM_OFFICER_NAME: QUINN, ASHLINN KO

PROJECT_TERMS: Accountability;Address;Adult;Adult asthma;Affect;Allergic;Assessment tool;Asthma;asthma exacerbation;asthmatic;authority;Characteristics;Child;Childhood;Childhood Asthma;Communities;community organizations;cost;Data;demographics;Development;Emergency department visit;expectation;Exposure to;fungus;Genes;Growth;Health;Home;Home visitation;Housing;improved;Individual;innovation;insight;Institute of Medicine (U.S.);Intervention;Intervention Studies;Legal;Link;Low income;lower income families;Measurement;Mental Health;Meta-Analysis;Methods;Molds;Morbidity - disease rate;Neighborhoods;New York City;novel marker;Outcome;Policies;Prevalence;Procedures;programs;Public Health;public health intervention;Public Housing;pulmonary function;quality assurance;Recommendation;remediation;Reporting;Research Personnel;response;Sampling;Schools;successful intervention;Symptoms;System;Testing;Training;United States;Water;Work;World Health Organization

PROJECT_TITLE: Mold Policy Intervention in New York City Public Housing and Asthma Morbidity

STUDY_SECTION: CIHB

STUDY_SECTION_NAME: Community Influences on Health Behavior Study Section[CIHB]


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

PI_NAMEs: TAN, KAI  (contact)

PROJECT_TERMS: 3-Dimensional;Address;algorithm development;ATAC-seq;Atlases;Benchmarking;Biological Assay;Cell Nucleus;cell type;Cells;Collaborations;collaboratory;Computational algorithm;Computer software;Computing Methodologies;Coupled;Data;Data Analyses;Data Analytics;data exchange;data format;data integration;data management;Data Set;Databases;design;Detection;Development;Dimensions;diverse data;Encapsulated;Ensure;experience;Fluorescent in Situ Hybridization;Gene Expression Profile;Genetic Transcription;Genomics;Heart;heart dimension/size;Heterogeneity;Human;Human BioMolecular Atlas Program;Image;improved;indexing;Infrastructure;interoperability;large scale data;Leadership;Link;Measurement;Mediating;member;Metadata;Methods;microCT;Modeling;Molecular;molecular imaging;Multiomic Data;multiple omics;Ontology;open source;Organ;Output;Pathway interactions;Phase;Planet Earth;Quality Control;Regulatory Pathway;Reproducibility;Research;Research Personnel;RNA;serial imaging;Signal Pathway;software development;Software Tools;Spatial Distribution;Statistical Data Interpretation;Statistical Models;success;Taxonomy;Technology;Tissue atlas;tissue mapping;Tissues;virtual;Visualization

PROJECT_TITLE: Data Analysis Core

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IMST-U]


NIH_SPENDING_CATS: Aging;Cardiovascular;Clinical Research;Genetics;Heart Disease;Human Genome

PHR: PROJECT NARRATIVE – HEART OSP The human heart is vital for our survival and health. Our in-depth characterization of normal human hearts using 3D imaging and single-cell omics/imaging will lead to improved understanding of cardiac physiology as well as many human heart diseases that affect millions of Americans.

PI_NAMEs: PEI, LIMING  (contact)

PROJECT_TERMS: Address;Affect;Age;age group;Aging;Algorithms;American;Anatomy;Archives;Arteries;ATAC-seq;Atlases;Basic Science;biobank;Biological Assay;Biology;Biomedical Research;Cardiac;Cause of Death;Cell Nucleus;cell type;Cells;Clinical;Communities;complex data;computational pipelines;computerized tools;Computing Methodologies;Consent Forms;cost;Data;Data Analyses;data sharing;Databases;Detection;Development;Dimensions;Epigenetic Process;epigenomics;Ethnic Population;experience;Female;Fluorescent in Situ Hybridization;Follow-Up Studies;Freezing;Future;Gender;Genetic Transcription;genomic data;Genomics;Goals;Growth;Health;Heart;heart cell;Heart Diseases;Heterogeneity;Histologic;Human;Human BioMolecular Atlas Program;Image;improved;indexing;Infrastructure;Knowledge;life span;male;Medical;men;Metadata;Methods;microCT;Molecular;molecular imaging;Molecular Profiling;Multiomic Data;multiple omics;Organ;Phase;Physiological;Physiology;Positioning Attribute;Production;Proteomics;racial diversity;racial population;Regulatory Pathway;Research;Resolution;Sampling;searchable database;serial imaging;Series;Signal Pathway;single cell analysis;Small Nuclear RNA;Spatial Distribution;Specimen;Three-Dimensional Imaging;Tissues;transcriptome sequencing;transcriptomics;United States;user-friendly;Veins;Visualization;Woman

PROJECT_TITLE: Organ Specific Project - Heart


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Congenital Structural Anomalies;Epilepsy;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Neurodegenerative;Neurosciences;Pediatric;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PUBLIC HEALTH RELEVANCE Brain malformations that occur during human fetal development commonly lead to severe epilepsy and intellectual disability. In this study, we seek to identify the genetic bases of common subtypes of brain malformations and to determine the role of implicated genes on brain development in vivo and in vitro. This work will evaluate the role of somatic variants in brain malformations, improve the understanding of the genes and processes involved in brain development, and will begin to illuminate strategies for early detection and treatment options for patients suffering from these and related conditions.

PI_NAMEs: CRINO, PETER B;HEINZEN, ERIN L (contact)

PROGRAM_OFFICER_NAME: RIDDLE, ROBERT D

PROJECT_TERMS: Address;Adult;Affect;AKT Signaling Pathway;Award;base;Biological Markers;Biological Models;Brain;brain control;brain malformation;brain tissue;Candidate Disease Gene;Cell Proliferation;Cerebral cortex;Child;clinical phenotype;Clustered Regularly Interspaced Short Palindromic Repeats;Collection;Copy Number Polymorphism;Cortical Dysplasia;Cortical Malformation;Data;de novo mutation;Development;Disease;disease mechanisms study;disease-causing mutation;DNA Sequence Alteration;DNA sequencing;Early Diagnosis;Early treatment;Electroporation;Embryo;Enrollment;Epilepsy;Excision;exome;exome sequencing;Fertilization;Fetal Development;Foundations;FRAP1 gene;Funding;Future;gene discovery;Genes;Genetic;genetic architecture;Genetic Risk;Genetic study;genome sequencing;Germ Cells;Germ Lines;Goals;Grant;Guide RNA;hemimegalencephaly;Human;Hyperplasia;improved;in utero;In Vitro;in vitro Model;in vivo;in vivo Model;Individual;Induced pluripotent stem cell derived neurons;Inherited;Intellectual functioning disability;Intractable Epilepsy;Knock-out;knockout gene;Lead;loss of function;malformation in cortical development;Medical;Microgyria;migration;Modeling;Molecular;Morphology;Motility;Mus;Mutation;neocortical;nerve stem cell;neuroblastoma cell;Neurons;novel;Partial Epilepsies;Pathogenicity;Pathway interactions;Patients;Phenotype;PIK3CG gene;prevent;Process;Prognosis;Protein Subunits;public health relevance;Ras Signaling Pathway;Research;Resected;Risk;Role;screening;Seizures;Series;Short Tandem Repeat;Signal Transduction;Signaling Protein;Site;software development;Somatic Mutation;Specimen;stem cells;Structural defect;targeted sequencing;Tissues;Translating;Variant;whole genome;Work;zygote

PROJECT_TITLE: Identification and molecular characterization of somatic mutations in MCD

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Genetics;Human Genome;Immunotherapy

ORG_CITY: CHARLOTTE

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF NORTH CAROLINA CHARLOTTE

PHR: NARRATIVE The overall goal of this project is to establish the association of genetic polymorphism of the NK (natural killer) cell receptome in human populations. NK receptors are critical for innate immunity against tumors and are encoded by the highly polymorphic Leukocyte Receptor Complex (LRC, Chr 19) and Natural Killer Complex (NKC, Chr 12). To address our goals, we will deeply sequence the LRC and NKC in 18 ancestrally diverse human populations and leverage our expertise in bioinformatic analysis to integrate genetic data with single-cell transcriptome sequencing to search for expression quantitative trait loci (eQTL) markers.

PI_NAMEs: AUGUSTO, DANILLO G (contact)

PROGRAM_OFFICER_NAME: PAZIN, MICHAEL J

PROJECT_TERMS: 19q13;Address;African;African American population;Alleles;American;Amerindian;Bioinformatics;bioinformatics pipeline;Bolivia;C Type Lectin Receptors;cancer cell;Cells;Characteristics;Chromosome 19;Code;Complex;Comprehension;Copy Number Polymorphism;Custom;cytotoxicity;Data;design;differential expression;Disease;DNA;Elements;European;Exhibits;experience;Future;Gene Cluster;Gene Expression Regulation;Gene Family;Genes;Genetic;Genetic Polymorphism;Genetic Transcription;Genetic Variation;genome wide association study;Genomic Segment;genomic variation;Genotype;Germ Cells;Goals;Homologous Gene;Human;Immune response;Immunoglobulins;Individual;Infection;innovation;Killer Cells;Leukocytes;Linkage Disequilibrium;Malignant Neoplasms;Maps;Medical;Mononuclear;Native Americans;Natural Immunity;Natural Killer Cell Immunotherapy;Natural Killer Cells;Natural Selections;next generation sequencing;novel;Paraguay;Pattern;Peripheral;Peripheral Blood Mononuclear Cell;Peru;Population;Population Genetics;Quantitative Trait Loci;receptor;Receptor Cell;Role;Sampling;segregation;single cell sequencing;single-cell RNA sequencing;South Africa;South America;South Asian;synergism;transcriptome;transcriptome sequencing;Translating;tumor;Validation;Variant;Work

PROJECT_TITLE: Defining Variation in the Natural Killer Cell Receptome in Human Populations

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-P(54)]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Neurosciences;Nutrition;Obesity

ORG_CITY: BATON ROUGE

ORG_NAME: LSU PENNINGTON BIOMEDICAL RESEARCH CTR

ORG_STATE: LA

PHR: In humans and rodents, physiological adaptations of food intake and energy expenditure ensure the maintenance body temperature and body weight during environmental challenges of ambient temperature or fasting, but those adaptations are also a major hurdle to maintain weight loss after dieting in obese patients.  We identified a population of neurons that respond to the hormone leptin that modulates physiological adaptations in response to ambient temperature and fasting, and represents an excellent model to investigate the neuronal circuits that integrate physiological adaptations to temperature and energy state.  This proposal aims to work towards a cohesive model how physiological adaptations are mediated in the brain and has implications for metabolic studies in humans and animals that guide treatment strategies for weight loss in obese patients.

PI_NAMEs: MUENZBERG-GRUENING, HEIKE  (contact)

PROGRAM_OFFICER_NAME: COOKE, BRAD

PROJECT_TERMS: Affect;Anatomy;Animals;anorexic;Award;Body Temperature;Body Weight;Body Weight Changes;Body Weight decreased;Brain;Brown Fat;Data;Dependence;dieting;Disease;Dissociation;Eating;Energy Metabolism;Ensure;Expenditure;experimental study;Fasting;feeding;Food Energy;food restriction;Genetic;Glutamates;Goals;Health;Histologic;Homeostasis;Hormones;Human;Hypothalamic structure;improved;Knowledge;Leptin;leptin receptor;Leptin resistance;lifestyle intervention;Maintenance;Mediating;Melanocortin 4 Receptor;Metabolic;metabolic abnormality assessment;Metabolic Control;Methods;Modeling;Motor Neurons;neuronal circuitry;Neurons;novel;obese patients;Obesity;Obesity Epidemic;Pathologic;Peptides;Peripheral;Pharmaceutical Preparations;physiologic model;Physiologic Thermoregulation;Physiological;Physiological Adaptation;Play;Population;Preoptic Areas;prevent;Pro-Opiomelanocortin;Regulation;Research;response;Rodent;Role;Site;Structure of nucleus infundibularis hypothalami;Temperature;Temperature Sense;Testing;treatment strategy;Weight;weight maintenance;Work

PROJECT_TITLE: Integration of Lepr circuits for thermoregulation and energy status

STUDY_SECTION: IPOD

STUDY_SECTION_NAME: Integrative Physiology of Obesity and Diabetes Study Section[IPOD]


NIH_SPENDING_CATS: Autoimmune Disease;Digestive Diseases;Eye Disease and Disorders of Vision;Microbiome

PHR: Project Narrative The mechanisms that cause autoimmune uveitis are not well understood, and thus, treatments to prevent blindness from this condition are limited. We will investigate a new pathway of disease through disruptions in the gut microorganisms. By changing these gut microorganisms to reestablish a balance in the immune system, we can potentially develop improved ways of treatment for autoimmune uveitis.

PI_NAMEs: LIN, PHOEBE  (contact)

PROGRAM_OFFICER_NAME: GORDIYENKO, NATALIYA

PROJECT_TERMS: Address;Adoptive Transfer;Affect;Animals;Anti-Inflammatory Agents;Antibiotics;Arthritis;Autoimmune Diseases;autoimmune uveitis;Bacteria;Biological Assay;Biological Markers;Blindness;Body part;cell motility;cell type;Cells;Chronic;Dietary Fiber;Disease;Disease Pathway;drinking water;effector T cell;Equilibrium;Eye;fecal transplantation;Fermentation;Frequencies;Goals;gut inflammation;gut microbiota;Homeostasis;Immune;Immune system;Immunity;Immunophenotyping;Immunosuppression;improved;In Vitro;in vivo;Inflammation;Inflammatory;insight;Intervention;intestinal barrier;intestinal epithelium;intestinal homeostasis;Intestinal permeability;Intestines;Left;Link;Lymphoid Tissue;Measures;Mediating;Medical;Metronidazole;microbial;microbiota;microorganism;migration;Modeling;Morphology;mouse model;Mus;new therapeutic target;novel;novel strategies;novel therapeutic intervention;Pathogenesis;Peripheral;prevent;Production;Propionates;protective effect;Proteins;Severities;side effect;T-Lymphocyte;Testing;therapeutic target;Time;trafficking;Transgenic Organisms;Uveitis;Volatile Fatty Acids

PROJECT_TITLE: Intestinal T cells and microbiota as therapeutic targets in autoimmune uveitis


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Aging;Biomedical Imaging;Breast Cancer;Cancer;Clinical Research;Prevention;Women's Health Research

ORG_DEPT: SURGERY

PHR: PROJECT NARRATIVE Mammographic breast density is one of the strongest risk factors for breast cancer. A reduction in mammographic breast density over time is associated with a decrease in breast cancer incidence. Therefore, the identifying biological pathways that can be targeted to reduce density and breast cancer incidence is crucial. In this proposal, we will use high-throughput state-of-the art, well-validated metabolomics platforms to investigate the metabolome of mammographic density in premenopausal women.

PI_NAMEs: TORIOLA, ADETUNJI T (contact)

PROGRAM_OFFICER_NAME: NELSON, STEFANIE A

PROJECT_TERMS: Acceleration;African American;African American population;Age;aged;Amino Acids;Biological;Biological Markers;biological systems;biomarker identification;Blood;Blood specimen;Breast;Breast Cancer Prevention;Breast Cancer Risk Factor;breast density;Cancer Etiology;Case/Control Studies;Chemoprevention;Coupled;Data;density;Development;Diagnosis;Disease;Enrollment;Ensure;Etiology;Fasting;follow-up;Future;Health;Incidence;innovation;insight;Lipids;Malignant Breast Neoplasm;Malignant Neoplasms;Mammographic Density;Mammography;Measures;Mediating;medical schools;metabolome;metabolomics;Modeling;Molecular;Molecular Weight;Not Hispanic or Latino;novel;novel strategies;Nucleotides;Obesity;Participant;Pathway interactions;Performance;Population Heterogeneity;Premenopause;Prevention trial;Primary Prevention;Questionnaires;Race;real world application;recruit;Reproducibility of Results;Research;Research Design;risk prediction;routine screening;screening;secondary analysis;Source;study population;success;Surrogate Markers;Techniques;Time;Tissues;tool;Translating;Universities;Validation;Variant;Washington;Woman;Women's study;young woman

PROJECT_TITLE: Metabolite Profiles and Mammographic Density in Premenopausal Women

STUDY_SECTION: CHSB

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology B Study Section[CHSB]


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Nutrition;Obesity;Physical Activity;Prevention

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative Exercise is often found to markedly improve metabolic health in obesity, but the mechanisms underlying this protective effect of exercise remain unresolved, and almost nothing is known about the direct effects of exercise on the structure and function of fat tissue (i.e., adipose tissue). Many obesity-related health complications are linked with abnormalities in structure and metabolic function of adipose tissue, such as enlarged fat cells, reduced vasculature, and increased fibrosis. The overall goals of this project are to assess the effects of exercise on changes in the structure and function of adipose tissue as adults with obesity lose weight. Expanding our understanding about how exercise impacts the structure and metabolic function of adipose tissue in ways that can translate to marked improvements metabolic health will help optimize targeted strategies for obesity-related diseases.

PI_NAMEs: HOROWITZ, JEFFREY F (contact)

PROGRAM_OFFICER_NAME: BLONDEL, OLIVIER

PROJECT_TERMS: Abdomen;Adipocytes;Adipose tissue;adult obesity;angiogenesis;Blood capillaries;blood lipid;Blood Pressure;Body fat;Body Weight;Body Weight decreased;Caloric Restriction;Capillarity;cardiometabolism;Cell Size;Cells;Circulation;Clinical;clinically relevant;Dendritic Cells;density;Deposition;Diet;dietary restriction;Disease;Endothelial Cells;Event;Exercise;exercise intensity;exercise training;Extracellular Matrix;Fatty acid glycerol esters;Fatty Acids;Fibrosis;follow-up;Gene Expression;Genes;glucose tolerance;Goals;Health;Health Benefit;Hour;Immune;improved;Infiltration;Inflammatory;insight;Insulin Resistance;Interval training;lifestyle intervention;Link;lipid biosynthesis;Lipids;Lipolysis;Liver;Macrophage;Maintenance;Measures;Metabolic;Modification;Morphology;novel;Nuclear RNA;Obesity;Obesity associated disease;obesity prevention;obesity treatment;Outcome;Pathway interactions;Pericytes;Phase;Post-Translational Protein Processing;precursor cell;programs;protective effect;Protocols documentation;Randomized;Regulation;Research Design;response;Signal Pathway;Signal Transduction;single nucleus RNA-sequencing;Skeletal Muscle;Standardization;stem;Structure;subcutaneous;Time;Tissues;Training;transcriptome sequencing;Translating;Visceral;Weight;weight loss intervention;weight loss program

PROJECT_TITLE: Exercise effects on adipose tissue morphology, metabolic function, and metabolic health with weight loss and weight regain in obesity


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: PROJECT NARRATIVE The goal of this training grant is to educate a cadre of outstanding scholars seeking either a PhD degree or postdoctoral training (for both DDS/MD and PhD graduates) to pursue basic, fundamental, translational, or clinical research and prepare for careers relevant to dental and craniofacial disease and health. We recognize the significant contributions of international scientists, clinician-scientists and underrepresented minorities to dental and craniofacial research, mentoring, and teaching; and, we strive to appoint trainees with very diverse research experiences, background and education. Our aim is to develop a diverse cohort of independent scientists who will have a significant impact on the dental, oral and craniofacial health-related research needs of the nation, and the world.

PI_NAMEs: PAINE, MICHAEL LANSDELL (contact)

PROGRAM_OFFICER_NAME: MCGUIRL, MICHELE

PROJECT_TERMS: Address;Applications Grants;Appointment;Award;Behavioral Research;Biology;Biomedical Research;Clinical;Clinical Research;cohort;craniofacial;Dental;Dental Education;Discipline;Disease;Doctor of Philosophy;Education;Educational process of instructing;Educational workshop;Enrollment;Ensure;Faculty;Financial Support;Fostering;Funding;Future;Goals;Grant;Health;Institution;interest;International;Interview;Investments;medical schools;Mentors;Mentorship;Mission;National Institute of Dental and Craniofacial Research;National Research Service Awards;next generation;Oral;Oral health;Outcome;Peer Review Grants;post-doctoral training;Postdoctoral Fellow;pre-doctoral;Principal Investigator;programs;Qualifying;Recording of previous events;Research;Research Personnel;Research Training;role model;School Dentistry;Scientist;Time;Training;training opportunity;Training Programs;Underrepresented Minority;Workplace;Writing

PROJECT_TITLE: Doctoral and Post-doctoral Training in Craniofacial Biology


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

ORG_CITY: HOBOKEN

ORG_DEPT: CHEMISTRY

ORG_NAME: THE TRUSTEES OF THE STEVENS INSTITUTE OF TECHNOLOGY

ORG_STATE: NJ

PHR: Project Narrative The proposed research program is relevant to public health because it seeks to develop novel molecular building blocks that will significantly expand the chemical space for drug discovery. The project will also provide new tools to functionalize and probe therapeutically important proteins.

PI_NAMEs: SHARMA, ABHISHEK  (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TERMS: Biological;Biology;Boron;Chemicals;Data;drug discovery;Goals;Laboratory Research;Medicine;Methods;Molecular;Natural Products;novel;Pattern;Pharmaceutical Chemistry;Play;Preparation;programs;protein protein interaction;Proteins;Public Health;Publishing;Reporting;Research;Research Project Grants;Role;Route;scaffold;Therapeutic;tool;Work

PROJECT_TITLE: Novel Acylborons and Alpha-hydroxy Borons to Enable Modular, Regio- and Stereocontrolled Synthesis of Bioactive Molecules and Protein Conjugates

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-Q(55)R]


NIH_SPENDING_CATS: Cancer

ORG_CITY: CHICAGO

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative This program in Epigenetics and Metabolism in Cancer will prepare postdoctoral students for research careers investigating epigenetic and metabolic changes in cancer and how these cellular processes can be targeted therapeutically. Mentorship and a personalized training plan will ensure the development of researchers able to bridge these disciplines which will be essential for improving cancer outcomes.

PI_NAMEs: SHILATIFARD, ALI  (contact)

PROGRAM_OFFICER_NAME: LIM, SUSAN E

PROJECT_TITLE: Epigenetics, Metabolism and Cancer

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


ORG_CITY: PORTLAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Project Narrative Despite its societal importance, and prevalence as high as 5-7%, the underlying etiology of male infertility is unknown in up to half of infertile men. With an improved understanding of the genetic causes of male infertility, patient genetic information will transform the way that male infertility is diagnosed and treated. Our international, multicenter study of male infertility genetics will build the resources necessary to bring male infertility care into the era of personalized genomic medicine.

PI_NAMEs: ASTON, KENNETH IVAN;CONRAD, DONALD F. (contact)

PROGRAM_OFFICER_NAME: KENT, TRAVIS JOHN

PROJECT_TERMS: Affect;Alleles;analytical tool;Architecture;biobank;Biological Assay;Biological Models;cancer type;Cardiovascular Diseases;Caring;causal variant;Chromosome Mapping;Clinical;cohort;Collaborations;comorbidity;Complex;Computer software;Diabetes Mellitus;Diagnosis;Disease;Electronic Medical Records and Genomics Network;epidemiologic data;Epidemiology;Etiology;exome sequencing;Experimental Designs;Funding;Generations;Genes;Genetic;genetic architecture;genetic information;genetic variant;Genome;Genomics;Goals;Health;Heterozygote;Impairment;improved;Infertility;International;Knowledge;Life;Link;loss of function;Male Infertility;Malignant Neoplasms;men;Methods;model organism;Modeling;Molecular;Morphology;Multicenter Studies;Mutation;National Institute of Child Health and Human Development;novel;Patients;personalized genomic medicine;Phase;phenome;Phenotype;Prevalence;Productivity;recruit;Reproductive Medicine;Research;Resources;Risk;Risk Factors;risk stratification;Role;Seminal fluid;single-cell RNA sequencing;sperm cell;Statistical Methods;Testicular Tissue;Testing;Testis;Tissues;tool;United States National Institutes of Health;Utah;Validation;Variant;Work;Zebrafish

PROJECT_TITLE: Genomics of spermatogenic impairment

STUDY_SECTION: ICER

STUDY_SECTION_NAME: Integrative and Clinical Endocrinology and Reproduction Study Section[ICER]


NIH_SPENDING_CATS: Autoimmune Disease;Brain Disorders;Multiple Sclerosis;Neurodegenerative;Neurosciences;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Long thought to be a passive structure, recent evidence shows that experience-dependent generation and remodeling of white matter myelin by oligodendrocytes is critical for learning, memory, and cognitive function. Our proposal incorporates an innovative and cross-disciplinary approach to dissect the mechanisms underlying the regulation of gray and white matter oligodendrocyte plasticity and regeneration.

PI_NAMEs: HUGHES, ETHAN GARRETT (contact)

PROGRAM_OFFICER_NAME: TYLER, WILLIAM A

PROJECT_TERMS: Adult;Age;Area;Axon;Behavior;Behavior Therapy;Behavioral;Biology;Brain;Brain region;cell behavior;Cell Death;Cell Differentiation process;Cell Lineage;Cell Proliferation;Central Nervous System;central nervous system demyelinating disorder;cognitive function;Communities;Cortical Column;Cues;Data;Demyelinations;Development;effectiveness evaluation;efficacy testing;Environment;experience;Fluorescence;Future;Generations;gray matter;illness length;in vivo;in vivo imaging;Individual;Inflammatory;Injury;innovation;insight;Knowledge;Learning;Lesion;Life;Memory;Methodology;Monitor;motor learning;Multiple Sclerosis;multiple sclerosis patient;Myelin;Myelin Sheath;myelination;Natural regeneration;neuronal cell body;Neurons;novel;novel therapeutics;oligodendrocyte lineage;oligodendrocyte progenitor;Oligodendroglia;Optics;Pathologic;Patients;Penetration;Persons;Photons;Physics;precursor cell;Recovery of Function;regenerative;regional difference;Regulation;remyelination;repaired;Research;Shapes;Structure;therapeutic candidate;three photon microscopy;Tissue imaging;Tissues;tool;United States;white matter;white matter damage;White Matter Disease

PROJECT_TITLE: In vivo three-photon microscopy of the cortical gray and white matter

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


NIH_SPENDING_CATS: Aging;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Eye Disease and Disorders of Vision;Macular Degeneration;Neurodegenerative;Neurosciences

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative This project will advance understanding of remapping, a method to improve reading in patients with blind spots in their vision. The method tracks the location of a patient’s blind spot as they read text on a video screen, and shifts letters from inside the blind spot to nearby locations on the screen where they can be read. The project will test whether remapping can be used successfully in people with eye disease, and whether it can be personalized to work with each patient’s unique pattern of blind spots and residual reading ability.

PI_NAMEs: ENGEL, STEPHEN A. (contact);KOOZEKANANI, DARA ;LEGGE, GORDON E

PROGRAM_OFFICER_NAME: WIGGS, CHERI

PROJECT_TERMS: Age related macular degeneration;Basic Science;Blindness;Central Scotomas;Data;Disease;Effectiveness;effectiveness testing;experimental study;Eye diseases;Eye Movements;Family;Geometry;Goals;head mounted display;Image;Impairment;improved;Individual;individual patient;Knowledge;Left;Letters;light weight;Location;Macular degeneration;Maps;Measures;Methods;Modeling;Nonexudative age-related macular degeneration;novel;object recognition;Patients;Pattern;Performance;Perimetry;peripheral reading;Persons;process improvement;Quality of life;Reading;reading ability;reading difficulties;Residual state;Retina;Retinal blind spot;Scotoma;Self-Help Devices;Shapes;Speed;Techniques;Technology;Testing;Text;Time;Vision;Visual;Visual Acuity;Visual Aid;Visual Fields;Visual impairment;visual map;visual performance;Work

PROJECT_TITLE: Remapping the Visual Field to Aid Reading with Central Scotomas


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Data Science;Drug Abuse (NIDA only);Mental Health;Networking and Information Technology R&D (NITRD);Neurosciences;Opioid Misuse and Addiction;Opioids;Pediatric;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: SAINT LOUIS

ORG_DEPT: NEUROLOGY

ORG_NAME: WASHINGTON UNIVERSITY

PHR: PROJECT NARRATIVE The Healthy Brain and Child Development (HBCD) study will establish a state-of-the-art, longitudinal data set from a cohort of 7,500 mother-child dyads that will address essential questions regarding the impact of high-risk environments, including prenatal substance exposure, on brain and behavioral health and developmental trajectories. The project will include multi-site data collection across a wide range of modalities including harmonized neuroimaging, neurophysiology, behavioral and cognitive assessments, and the collection of biospecimens. The proposed HBCD National Consortium Data Coordinating Center will provide the leadership, overall management, and primary oversight of all data collection, quality control, storage, management, sharing, and analytics necessary to ensure the project’s success.

PI_NAMEs: DALE, ANDERS M;FAIR, DAMIEN A;SMYSER, CHRISTOPHER DANIEL (contact)

PROGRAM_OFFICER_NAME: PRABHAKAR, JANANI

PROJECT_TERMS: access restrictions;Accountability;Accounting;Address;Affect;age related;Behavior assessment;Behavioral;behavioral health;behavioral outcome;Bioinformatics;Biological;Biological Factors;Biometry;Birth;Brain;brain health;Characteristics;Child;Child Development;Child Health;Childhood;Clinical;clinical care;Clinical Data;clinical data warehouse;cognitive testing;cohort;Cohort Studies;Collaborations;Collection;Communities;computerized data processing;computing resources;critical period;Data;data access;Data Analyses;Data Analytics;data and analysis portal;Data Collection;data collection site;Data Coordinating Center;data exploration;data harmonization;data management;data platform;data registry;data resource;Data Set;data tools;Databases;demographics;design;Development;Electroencephalography;electronic health data;Electronic Health Record;electronic health record system;Enrollment;Ensure;Environment;Environmental Exposure;Environmental Impact;Environmental Risk Factor;Epidemiology;Ethnic Origin;Evaluation;experience;Family;fetal substance exposure;flexibility;follow-up;Genetic;Goals;Health Insurance Portability and Accountability Act;Helping to End Addiction Long-term;Heterogeneity;high dimensionality;High Performance Computing;high risk;improved;infancy;Infant;Infrastructure;innovation;Investigation;Leadership;Life;Link;Location;longitudinal dataset;Magnetic Resonance Imaging;magnetic resonance imaging/electroencephalography;Measures;Methods;Modality;Monitor;Mothers;multidisciplinary;multimodal data;multimodality;neurobehavioral;neurodevelopment;neuroimaging;neurophysiology;new technology;Opiate Addiction;Opioid;opioid misuse;Parents;Participant;Personal Satisfaction;Personally Identifiable Information;Persons;Policies;Population;Pregnancy;Pregnant Women;prenatal;Privacy;Procedures;prospective;Protocols documentation;Public Health;Public Policy;Quality Control;Questionnaires;Race;recruit;Regulation;Reproducibility;Research;resilience;Resources;Sampling;Schedule;Secure;Shapes;Site;sociodemographics;socioeconomics;Spectrum Analysis;Speed;Standardization;Statistical Data Interpretation;stem;substance use;success;System;Technology;therapy design;Time;Toddler;tool;Training;United States National Institutes of Health;validation studies;Vendor;Vertebral column;wearable sensor technology;Woman

PROJECT_TITLE: Healthy Brain and Child Development National Consortium Data Coordinating Center

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-Z(50)]


ORG_CITY: SEATTLE

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE Obesity and associated metabolic disorders have emerged as leading health problems in the U.S. and, increasingly, globally as well. Both preventing obesity and lowering the health risks of obesity once it occurs, require advancing understanding of its underlying causes. The NORC offers valuable resources to a large group of researchers at UW investigating nutrition, obesity, and associated disorders.

PI_NAMEs: SCHUR, ELLEN A (contact)

PROGRAM_OFFICER_NAME: EVANS, MARY

PROJECT_TERMS: Animal Model;Area;Assessment tool;Award;base;Basic Science;Bioinformatics;Biological Assay;Biomedical Research;Biometry;Body Composition;Body measure procedure;Brain;Child;Clinical;Clinical Nutrition;Clinical Research;Collaborations;Communities;Complex;cost;cost effective;Dedications;design;Dietary Assessment;Direct Costs;Disease;Education;energy balance;Energy Intake;Energy Metabolism;Ensure;Environment;epidemiology study;Exercise Test;exercise training;Faculty;Fatty acid glycerol esters;Fostering;Fred Hutchinson Cancer Research Center;Funding;Goals;Health;Hepatic;Human;Human Resources;Institution;Laboratories;Magnetic Resonance Imaging;Measures;medical schools;Metabolic;Metabolic Diseases;Metabolism;metabolomics;Motor Activity;multidimensional data;next generation;non-invasive imaging;novel strategies;nutrition;Nutrition Assessment;Nutritional;Nutritional Study;Obesity;obesity prevention;obesity risk;operation;Pathogenesis;Phenotype;Physiologic Thermoregulation;Plasma;preclinical study;Preparation;Productivity;programs;Public Health Schools;Research;Research Design;Research Personnel;Research Support;Resources;Rodent;Rodent Model;Roentgen Rays;Schools;Science;Services;Structure;Tissues;Training;Training and Education;Translational Research;Universities;Washington

PROJECT_TITLE: Nutrition Obesity Research Center


NIH_SPENDING_CATS: Nutrition;Obesity

PI_NAMEs: SCHWARTZ, MICHAEL W (contact)

PROJECT_TITLE: Admin Core


PI_NAMEs: MORTON, GREGORY J (contact)

PROJECT_TERMS: Address;Analysis of Covariance;Animal Model;Animals;Area;base;Behavioral;Biological Assay;Biological Process;Biopsy Specimen;Body Temperature;Brown Fat;Cardiovascular Diseases;Communities;comorbidity;Computer software;Consult;cost effective;Data;Data Analyses;design;Development;Diabetes Mellitus;Educational process of instructing;Educational workshop;energy balance;Energy Intake;Energy Metabolism;Ensure;Equipment;evidence based guidelines;experience;Funding;genetic manipulation;High Prevalence;Homeostasis;Human Resources;Humidity;Hypertension;improved;Indirect Calorimetry;innovation;instrumentation;interest;Intervention;Knowledge;Leadership;Linear Regressions;Measurement;Measures;Metabolic;metabolic abnormality assessment;metabolic phenotype;Methods;Modeling;Monitor;Mus;National Institute of Diabetes and Digestive and Kidney Diseases;next generation;novel therapeutic intervention;nutrition;Nutritional Science;Obesity;organizational structure;Pathogenesis;Pattern;Performance;pharmacologic;Phenotype;Physiologic Thermoregulation;Physiological;Physiology;Play;Procedures;Process;Productivity;programs;Provider;Public Health;Quality Control;Regulation;Research;Research Design;Research Personnel;Resources;respiratory;Rodent;Rodent Model;Role;Running;Scientific Advances and Accomplishments;service providers;Services;skills;Spirometry;Tail;Techniques;Technology;Temperature;Testing;therapeutically effective;Thermogenesis;Time;Tissues;tool;Training;Training Activity;training opportunity;Universities;Washington

PROJECT_TITLE: Energy Balance Core


PI_NAMEs: HOOFNAGLE, ANDREW N (contact)

PROJECT_TERMS: absorption;Address;Albumins;American;Animals;Area;assay development;Basic Science;Biological Assay;Biological Markers;bone;Calcium;Cells;Clinical;Clinical Chemistry;Clinical Research;cohort;Collection;college;Communities;complex data;Complex Mixtures;Concentration measurement;cost effective;Data;Data Analyses;Data Set;design;Development;Edetic Acid;Ensure;Experimental Designs;fibroblast growth factor 23;Foundations;Future;Genetic Engineering;Genetic Polymorphism;Genomics;Human;Human Resources;Immunochemistry;improved;inorganic phosphate;instrument;interest;Laboratories;Leadership;Liquid Chromatography;Logistics;Mass Fragmentography;Mass Spectrum Analysis;Measurement;Measures;meetings;Metabolism;metabolomics;Methodology;Minerals;Mutation;new technology;NMR Spectroscopy;novel;nutrition;Obesity;Pathologist;Patient Care;Persons;Plasma;Play;Population;Positioning Attribute;Potentiometry;preservation;Procedures;Process;Proteins;Proteomics;Protocols documentation;PTH gene;Quality Control;Recording of previous events;Reproducibility;Research;Research Design;Research Personnel;Resources;Role;sample collection;Sampling;Science;Serum;Services;Shapes;small molecule;Solid;Specimen;Statistical Methods;System;tandem mass spectrometry;Testing;Time;Tissues;Translational Research;Transportation;Tube;United States Food and Drug Administration;United States National Institutes of Health;Universities;Urine;Validation;Variant;Venous blood sampling;Vitamin D;Vitamin D-Binding Protein;Washington;Work

PROJECT_TITLE: Analytic Core


PROJECT_TERMS: Adipose tissue;base;Basic Science;Biometry;Blood;Body Composition;brain magnetic resonance imaging;Categories;Clinical;Clinical Investigator;Clinical Nutrition;Clinical Research;Collaborations;Common Core;Communities;Consultations;cost;cost effective;Dedications;design;Development;Diabetes Mellitus;dietary;Dietary Assessment;Epidemiology;Exercise Test;exercise training;Faculty;feeding;Food;Fostering;Fred Hutchinson Cancer Research Center;Frequencies;Gliosis;Goals;Hepatic;Human;Human Resources;Hypothalamic structure;Image;Improve Access;Institution;interdisciplinary collaboration;Interdisciplinary Study;Investments;Magnetic Resonance Imaging;medical schools;Medicine;meetings;member;Metabolic;Metabolism;Mission;National Institute of Diabetes and Digestive and Kidney Diseases;Nursing Research;nutrition;Nutrition Assessment;Nutritional Study;Obesity;Physical activity;Physics;Preparation;programs;Protocols documentation;Questionnaires;Radiology Specialty;Research;research facility;Research Personnel;research study;Research Support;Resources;Roentgen Rays;Sampling;Schools;Science;Services;Surveys;System;Techniques;tool;Training;Translational Research;translational scientist;Universities;Visceral fat;Washington

PROJECT_TITLE: Clinical and Translational Research Services Core


NIH_SPENDING_CATS: Biotechnology;Data Science

ORG_DEPT: PHARMACOLOGY

PHR: Numerous biomedical data sets and knowledge sources have been developed and placed in the public domain, with each knowledge source covering a very specific area of biomedicine. Yet, the ability to answer complex biomedical questions requires concurrent exploration of multiple, integrated knowledge sources. The proposed ROBOKOP graph knowledgebase represents a unique query and answer platform that aims to accelerate and advance scientific discovery by providing users with a tool to simultaneously explore dozens of integrated and harmonized sources of biomedical knowledge.

PI_NAMEs: BIZON, CHRISTOPHER ;TROPSHA, ALEXANDER  (contact)

PROGRAM_OFFICER_NAME: DUNCAN, CHRISTOPHER GENTRY

PROJECT_TERMS: Academia;Acceleration;Address;adverse outcome;Age;Algorithms;Area;Asthma;asthma exacerbation;base;Biochemical;Biomedical Research;Case Study;Chemical Exposure;Clinical;Collection;Communities;community engagement;Complex;Coronavirus Infections;Coupled;Data;Data Set;Databases;design;Development;Disease;Disparate;Drug Exposure;drug induced liver injury;Ensure;FAIR principles;flexibility;Generations;Genes;Goals;Graph;graph knowledge base;Growth;hackathon;high throughput technology;Immune;improved;Individual;Industry;Informatics;Infrastructure;Ingestion;innovation;International;Knowledge;Knowledge Discovery;knowledge graph;knowledge integration;knowledgebase;light weight;Link;Lung Diseases;Maintenance;Mediating;method development;Methodology;Mining;network models;novel;Outcome;Pathway interactions;Patients;Pharmaceutical Preparations;pollutant;Primary Ciliary Dyskinesias;Privatization;Proliferating;prototype;Public Domains;Publications;repository;Research;research and development;Resource Development;Review Literature;Science;Scientific Advances and Accomplishments;Semantics;Services;Source;Structure;success;Support System;System;Technology;Testing;tool;Translational Research;trend;user-friendly;virtual

PROJECT_TITLE: Supporting Biomedical Discovery with the ROBOKOP Graph Knowledgebase.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-T(55)]


PROJECT_TERMS: Applications Grants;Area;Award;Basic Science;Biometry;Body Weight;career;career development;Categories;Clinical;Clinical Research;Communities;comorbidity;Country;Data;Diabetes Mellitus;Discipline;Disease;Doctor of Philosophy;Educational workshop;energy balance;Ensure;Epidemiology;Ethics;experience;Faculty;Faculty Recruitment;Feedback;Funding;Goals;Grant;Infrastructure;Institution;Journals;Knowledge;Leadership;Measures;member;Metabolic;Metabolism;Mission;Monitor;new therapeutic target;next generation;nutrition;Obesity;obesity prevention;Pathogenesis;Peer Review;Peer Review Grants;Physicians;programs;Public Health;Publications;Qualifying;Regulation;Research;Research Personnel;responsible research conduct;Risk Factors;Role;Schools;Science;Scientist;Services;success;symposium;Talents;Time;Training;Translational Research;Universities;Washington

PROJECT_TITLE: Pilot and Feasibility Program


NIH_SPENDING_CATS: Diabetes;Nutrition;Obesity

PI_NAMEs: THALER, JOSHUA P (contact)

PROJECT_TERMS: Area;Award;Basic Science;career development;Clinical;Clinical Research;Collaborations;Communities;Community Health;Cystic Fibrosis;Diabetes Mellitus;Education;Educational Curriculum;Educational workshop;Endocrinology;Environment;Epidemiology;Event;experience;Exposure to;Faculty;Fellowship;Fostering;Funding;Goals;Grant;interest;Joints;lectures;Letters;Link;Medicine;Metabolism;Mission;Notification;nutrition;nutrition education;Nutritional;Obesity;organizational structure;Pacific Northwest;Policy Research;Postdoctoral Fellow;posters;professor;programs;Public Policy;Research;Research Institute;Research Personnel;Research Training;Science;Scientist;skills;success;symposium;Training;training opportunity;Training Programs;Training Support;Translational Research;Translations;United States National Institutes of Health;Universities;Visit;Washington;Work;Writing

PROJECT_TITLE: Enrichment Program


NIH_SPENDING_CATS: Neurosciences

ORG_DEPT: BIOMEDICAL ENGINEERING

PHR: PROJECT NARRATIVE The goal of this T32 program is to rigorously train postdoctoral fellows and resident/fellowship-stage clinical associates in an immersive, collaborative program building upon the strengths of the University of Minnesota's expertise in translational neuroscience, medical device design, and clinical trials that advance neuromodulation technologies for the treatments of brain disorders, spinal cord injuries, cardiometabolic and inflammatory disorders, and brain cancer.

PI_NAMEs: JOHNSON, MATTHEW DOUGLAS (contact)

PROGRAM_OFFICER_NAME: WEIGAND, LETITIA ALEXIS

PROJECT_TERMS: neuroregulation;Training Programs

PROJECT_TITLE: Training Program in Translational Neuromodulation


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

ORG_CITY: NEW YORK

ORG_DEPT: GENETICS

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: PROJECT NARRATIVE  This project will establish a first-of-its-kind platform for spatial functional genomics (Perturb-map), which will enable broad phenotypic analysis of 100s of genes in parallel within a tissue or tumor at cellular resolution and with spatial architecture preserved. This will greatly accelerate functional annotation of the genome and discovery of tissue and tumor biological control in a manner and scale not currently possible, and thus transform efforts to uncover the intrinsic components of different diseases and facilitate the development of drugs to treat these diseases.

PI_NAMEs: BROWN, BRIAN D (contact)

PROGRAM_OFFICER_NAME: KIM, HYE-SOOK

PROJECT_TERMS: Acceleration;Address;Affect;Antibodies;Architecture;Area;Bar Codes;Behavior;Biological;Biological Process;Biology;cancer biomarkers;cancer cell;cancer immunotherapy;Cell Adhesion Molecules;Cell Communication;cell killing;cell motility;Cell Nucleus;cell type;Cells;Cellular Morphology;chemokine;Clustered Regularly Interspaced Short Palindromic Repeats;combinatorial;Complex;CRISPR library;cytokine;Cytometry;Cytoplasm;density;Development;Dimensions;Disease;drug development;Drug resistance;Environment;Epitopes;Exclusion;extracellular;functional genomics;Gene Expression;gene function;Genes;Genetic;genetic signature;Genome;genome annotation;Genomic approach;Goals;Guide RNA;high dimensionality;Hormones;Human Genome;Image;Immune;immune cell infiltrate;immune clearance;Immunity;Immunooncology;immunoregulation;Immunotherapy;in vivo;Inflammatory;innovation;insight;interest;Invaded;Knock-out;knockout gene;Libraries;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant Neoplasms;Maps;Medicine;Methods;Motivation;multiplexed imaging;Necrosis;Neoplasm Metastasis;new technology;Normal tissue morphology;novel;Outcome;overexpression;Pharmaceutical Preparations;Pharmacotherapy;Phenotype;Population;predicting response;preservation;prevent;Process;Proliferating;Proteins;Publishing;recruit;Reporter;Research;Resistance;Resolution;response;Role;Set protein;Software Tools;Stains;Structure;System;T-Lymphocyte;targeted cancer therapy;Technology;Tissues;tumor;Tumor Immunity;tumor microenvironment;Tumor Tissue;vector;Work

PROJECT_TITLE: Development of a platform for spatial functional genomics

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BCMB-A(51)]


PHR: Project Narrative This project seeks to develop and test new compounds that block an enzyme, Tip60, in syngeneic murine tumor models. Tip60 targeting using a new type of inhibitor, called a PROTAC, may impair Tregs and facilitate host immune attack on tumor cells, and/or affect the response of tumor cells to radiation or cisplatin therapy. Our work is likely to lead to the development of new therapies for patients with cancers of the lung and other organs. !

PI_NAMEs: HANCOCK, WAYNE WILLIAM (contact)

PROGRAM_OFFICER_NAME: VENKATACHALAM, SUNDARESAN

PROJECT_TERMS: Acetylation;Acetyltransferase;Affect;Amino Acids;androgen independent prostate cancer;Androgen Receptor;anti-tumor immune response;antitumor effect;Apoptosis;Autoimmunity;Binding;Birth;C57BL/6 Mouse;cancer cell;cancer initiation;Cancer Model;cancer type;Cause of Death;Cell Separation;Cell Survival;Cells;Cessation of life;checkpoint therapy;chemotherapy;Chemotherapy and/or radiation;Cisplatin;clinical development;Clinical Trials;Complex;conventional therapy;Data;Development;Dimerization;DNA Binding;DNA Damage;DNA Repair;effector T cell;Enzymes;Event;FOXP3 gene;Genes;Genomic Instability;Growth;Histones;HTATIP gene;Human;Immune;immune checkpoint blockade;Immunity;Immunocompetent;Immunodeficient Mouse;immunoregulation;Immunotherapy;Impairment;In Vitro;in vivo;Individual;inhibitor;Investigation;Ionizing radiation;irradiation;Knock-in;Knock-in Mouse;Lead;lung cancer cell;Lung Neoplasms;Lysine;Malignant neoplasm of lung;Malignant Neoplasms;Modeling;Molecular;mouse model;Mus;neoplastic cell;novel therapeutics;Organ;Patients;phase 1 study;Population;preservation;prevent;Protac;protein degradation;Proteins;Radiation;Radiation therapy;recruit;Regulatory T-Lymphocyte;Resistance;response;Role;screening;T cell response;T-Lymphocyte;Testing;Therapeutic;therapeutic target;therapy resistant;tool;TP53 gene;Treatment Efficacy;treatment response;tumor;Tumor Escape;tumor growth;tumor microenvironment;ubiquitin ligase;ubiquitin-protein ligase;Vaccination;Work;Xenograft procedure

PROJECT_TITLE: PROTAC Targeting of Tip60 in Syngeneic Cancer Models Using Cereblon Knock-in Mice

STUDY_SECTION: CII

STUDY_SECTION_NAME: Cancer Immunopathology and Immunotherapy Study Section[CII]


NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Substance Misuse

ORG_CITY: TULSA

ORG_NAME: LAUREATE INSTITUTE FOR BRAIN RESEARCH

ORG_STATE: OK

PHR: PROJECT NARRATIVE American Indians (AI) suffer from a disproportionate burden of negative health and social consequences of substance use disorder (SUD), yet after decades of recognition and research there is surprisingly little scientific understanding why this is the case. Research in AI communities has demonstrated that traditional cultural engagement (TCE) is protective against, and aids in, resolving substance use disorder, but to date the underlying mechanisms of these salutogenic effects is unknown. In partnership with the Shawnee Tribe, this project aims to integrate community based participatory research and neuroscience tools to delineate the impact of TCE on risk and resilience for SUD and establish a novel framework for studying analogous cultural features in other populations as social determinants of health to advance health equity.

PI_NAMEs: WHITE, EVAN JAMES (contact)

PROJECT_TERMS: Address;Adult;American Indian community;American Indian Population;American Indians;Area;Awareness;Behavioral;Brain;Categories;Clinical;Cognitive;Collaborations;Communities;community advisory board;community based participatory research;community engagement;design;Disease;Disparity;Ethnic Origin;Evidence based intervention;experience;Focus Groups;Geographic Distribution;Health;Health Disparities Research;health equity;Home;Human;Individual;Inequity;Knowledge;Link;Methods;Modeling;multimodal neuroimaging;neural;neurobehavioral;Neurosciences;novel;Persons;Phase;Population;Prevalence;Prevention;Process;Race;racial minority population;Recovery;Religion;Research;resilience;resilience factor;Risk;Risk Factors;Role;Sampling;Science;social;social health determinants;Stimulus;Structure;substance misuse;Substance Use Disorder;substance use treatment;Techniques;tool;Tribes;Underserved Population

PROJECT_TITLE: Kipiyeecipsakiciipe "coming home": Establishing clinical cultural neuroscience as a tool for understanding the role of traditional cultural engagement in mitigating substance misuse and disorder


NIH_SPENDING_CATS: Clinical Research;Infectious Diseases;Lyme Disease;Prevention;Tickborne Diseases;Vector-Borne Diseases

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE The proposed study aims to uncover clinical, immunologic, and metabolic determinants of post-treatment Lyme disease (PTLD) and its underlying symptom phenotypes. As such, our goal is to generate fundamental knowledge about why certain patients develop PTLD while others regain their pre-morbid health. These findings may lead to the development of innovative therapeutic strategies as well as novel interventions to prevent or reduce the often significant symptom burden and functional impact of PTLD.

PI_NAMEs: AUCOTT, JOHN  (contact)

PROGRAM_OFFICER_NAME: BOWDEN, NADINE

PROJECT_TERMS: Acute;acute infection;Address;Aftercare;Antibiotic Therapy;Anxiety;Autoantibodies;Autoantigens;Autoimmune Process;biobank;Biology;Blood Pressure;Borrelia burgdorferi;candidate identification;Cellular Metabolic Process;Clinical;clinical care;clinical phenotype;clinical practice;clinically relevant;Coculture Techniques;cohort;Complex;cytokine;Data;Development;Disease;Disease Pathway;Environment;Enzyme-Linked Immunosorbent Assay;Etiology;Event;FDA approved;Flow Cytometry;Functional disorder;Future;Goals;Grant;Health;high dimensionality;Human;Immune;Immunologics;Immunology;Immunoprecipitation;In Vitro;Individual;Infection;innovation;insight;Intervention;Knowledge;Laboratories;Longitudinal Studies;Lyme Disease;machine learning algorithm;Mental Depression;Metabolic;Metabolic Pathway;Methods;Modeling;Modernization;Molecular;Musculoskeletal Pain;Neurologic Symptoms;novel;Outcome;pain symptom;Participant;participant enrollment;Pathogenesis;Pathway interactions;patient population;patient subsets;Patients;Peripheral Blood Mononuclear Cell;Persons;pharmacologic;Phenotype;Physiologic pulse;prevent;preventive intervention;Process;profiles in patients;Prospective, cohort study;Protein Array;Protein Microchips;Psychosocial Factor;Publishing;Quality of life;Recording of previous events;recruit;Reporting;Research;Risk;Risk Assessment;Risk Factors;Sampling;Sampling Studies;Scientific Advances and Accomplishments;Series;Serology;Serum;sex;Signs and Symptoms;Sorting;Standardization;Stressful Event;Subgroup;Symptom Burden;Symptoms;Syndrome;Testing;Therapeutic;therapeutic target;Time;transcriptome sequencing;translational research program;Translations;Treatment outcome;United States;Universities;Vector-transmitted infectious disease;Work

PROJECT_TITLE: Determinants of Post-Treatment Phenotypes in Lyme Disease


ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: Dan L Duncan Comprehensive Cancer Center at Baylor College of Medicine OVERALL - PROJECT NARRATIVE Cancer is a leading cause of morbidity and mortality in the United States and globally. The diagnosis and treatment of cancer are extraordinarily demanding and increasingly expensive with major impacts on our economy. Although overall survival from cancer has improved and certain cancers can be prevented or cured, much remains to be accomplished to improve patient outcome through research to develop novel strategies to prevent, diagnose early, and effectively treat this disease. The Dan L Duncan Comprehensive Cancer Center at Baylor College of Medicine has put together a strong multidisciplinary team of scientists, clinicians, educators, and community outreach experts to further improve survival from cancer both in our Catchment Area and globally, and to educate the scientists and clinicians of the future.

PI_NAMEs: REDDY, PAVAN  (contact)

PROGRAM_OFFICER_NAME: SHAFIK, HASNAA

PROJECT_TERMS: Area;Asian population;Basic Science;Biology;Black Populations;Cancer Burden;cancer cell;Cancer Center;Cancer Center Support Grant;cancer education;Cancer Model;cancer prevention;cancer survival;cancer therapy;Catchment Area;Cellular Metabolic Process;Child;Chromatin;Cities;Clinic;Clinical;clinical care;Clinical Data;Clinical Protocols;Clinical Sciences;Clinical Trials;Clinics and Hospitals;college;Communities;community engagement;Community Outreach;Comprehensive Cancer Center;Country;County;data management;Diagnosis;Disease;Early Diagnosis;Education;Education and Outreach;ethnic minority;Ethnic Origin;Ethnic Population;Evaluation;Evolution;Faculty;Funding;Future;gene therapy;Genetic Transcription;Geographic Locations;Goals;Health;health disparity;Hispanic Populations;Hospitals;implementation science;improved;in vivo;Individual;Industry;Infrastructure;Institution;Interdisciplinary Study;Investments;Laboratories;Lead;Malignant Breast Neoplasm;Malignant Childhood Neoplasm;Malignant Neoplasms;Medical center;Medicine;member;metropolitan;Mission;Morbidity - disease rate;mortality;multidisciplinary;NCI-Designated Cancer Center;next generation;novel strategies;Nuclear Receptors;outreach;outreach program;Patient Care;Patient-Focused Outcomes;Peer Review;Physicians;Play;Population;Population Growth;Population Heterogeneity;Population Sciences;prevent;Process;programs;Race;racial minority;racial population;Recommendation;recruit;Research;Research Peer Review;Resource Sharing;Role;Scientific Advances and Accomplishments;Scientist;Services;Signal Transduction;Source;Technology;Texas;Training and Education;Translating;Translational Research;Underserved Population;Uninsured;United States;United States Department of Veterans Affairs;United States National Institutes of Health;Vision

PROJECT_TITLE: Baylor College of Medicine Cancer Center-Cancer Center Support Grant

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


NIH_SPENDING_CATS: Burden of Illness;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

PI_NAMEs: HESLOP, HELEN E (contact)

PROJECT_TERMS: Address;Basic Science;Budgets;Cancer Burden;Cancer Center;Cancer Center Support Grant;Catchment Area;Clinical;Clinical Research;Clinical Sciences;college;Communication;Community Outreach;Complex;cost effective;Databases;Education;Ensure;Environment;Evaluation;Financial Support;Goals;Grant;Health;health disparity;improved;Infrastructure;Institution;Leadership;Malignant Neoplasms;Medicine;member;Mission;Monitor;mortality;outreach;Patient Care;Play;Population;Population Sciences;Process;Productivity;programs;Research;Research Infrastructure;Research Personnel;Resource Sharing;Resources;Role;Standardization;Strategic Planning;tool;Translational Research;Work

PROJECT_TITLE: Cancer Center Administrative Core


PI_NAMEs: FUQUA, SUZANNE AW (contact)

PROJECT_TERMS: anti-cancer research;Basic Science;Cancer Center;Cancer Center Support Grant;cancer education;Cancer Patient;career;career development;Clinical;Clinical Sciences;college;Comprehensive Cancer Center;design;Education;Education and Outreach;Educational Curriculum;Effectiveness;Evaluation;evidence base;experience;Faculty;Funding;Goals;graduate student;Health Professional;High School Student;Institution;interest;Leadership;lectures;Malignant Neoplasms;Medicine;member;Middle School Student;Modeling;next generation;Participant;Patient Care;Physicians;Play;Postdoctoral Fellow;Productivity;programs;Research;Research Personnel;science, technology, engineering, mathematics, and medicine;Scientist;Series;Students;summer research;synergism;Training;Training Activity;undergraduate student;Underrepresented Students

PROJECT_TITLE: Cancer Research Career Enhancement and Related Activities


PI_NAMEs: LEWIS, MICHAEL T. (contact)

PROJECT_TERMS: 3-Dimensional;Adoptive Cell Transfers;angiogenesis;Animal Model;animal resource;anti-cancer research;Area;Bioinformatics;Biological;Biology;Cancer Biology;Cancer Center;Cancer Center Support Grant;Cancer Model;Catchment Area;cell immortalization;Cell Line;Cells;Charge;Chick;chicken egg;Chickens;chimeric antigen receptor T cells;chorioallantoic membrane;Clinic;Clinical;Collaborations;Collection;college;Communities;Comprehensive Cancer Center;computer infrastructure;conditional knockout;cost;cost effective;Credentialing;CRISPR/Cas technology;Data;Development;Disease;DNA;DNA sequencing;Embryo;embryo cryopreservation;Embryo Transfer;embryonic stem cell;Emerging Technologies;Ensure;Equipment;Evaluation;exome;experimental study;Faculty;Fertilization in Vitro;Freezing;Funding;gene editing technology;gene replacement;Generations;Genes;Genetic Engineering;Genetically Engineered Mouse;Genome;genome editing;Hepatic;Human;Immune system;Immunocompromised Host;in vivo;in vivo Model;interest;International;Invaded;Investigational Therapies;Knock-in;Knock-out;Lung;Maintenance;Malignant Neoplasms;Medicine;metabolomics;Methods;Microinjections;Modeling;Molecular;mouse model;multiple omics;Mus;Mutation;Neoplasm Metastasis;nuclease;Organoids;patient derived xenograft model;Patients;Pre-Clinical Model;preservation;Process;Proteomics;Protocols documentation;rat genome;reconstitution;repository;Reproducibility;Research Personnel;Resource Sharing;Resources;response;Science;Service delivery model;Services;Site;sperm cryopreservation;Techniques;Technology;Therapeutic Studies;tissue resource;Tissues;transcriptome sequencing;Transformed Cell Line;Transgenes;Transgenic Organisms;Translating;Treatment Efficacy;tumor;tumor xenograft;Validation;whole genome;Work;Xenograft Model

PROJECT_TITLE: Advanced in Vivo Cancer Models


ORG_CITY: ATLANTA

ORG_DEPT: NEUROSURGERY

ORG_NAME: EMORY UNIVERSITY

PHR: PROJECT NARRATIVE Approximately one third of patients with temporal lobe epilepsy do not respond to currently available antiseizure drugs, and many are not candidates for surgical resection. Inhibiting granule cells of the hippocampus effectively arrests seizures in a mouse model of temporal lobe epilepsy, but translation of this therapy is being hampered by the inability to specifically target these cells in non-genetically modified organisms. In this project we will develop a viral vector to specifically deliver a gene therapy to inhibit the hippocampal granule cells in wild type mice with the goal of developing a novel and translatable gene therapy to stop seizures in patients with drug- resistant temporal lobe epilepsy.

PI_NAMEs: GROSS, ROBERT E;GUTEKUNST, CLAIRE-ANNE N (contact)

PROGRAM_OFFICER_NAME: CHURN, SEVERN BORDEN

PROJECT_TERMS: Ablation;adeno-associated viral vector;Adult;Alternative Therapies;Alzheimer's Disease;anti-cancer research;Anticonvulsants;axonal sprouting;Brain;Cells;Cessation of life;Chronic;Clinical Trials;comparative efficacy;dentate gyrus;designer receptors exclusively activated by designer drugs;Development;Disease;Disease Progression;Drug resistance;Early Intervention;effectiveness testing;efficacy evaluation;Enhancers;Epilepsy;Epileptogenesis;Equilibrium;Excision;expression vector;Face;Frequencies;Future;gene therapy;gene-targeted therapy;Genes;Genetic;Genomic Segment;Glutamates;Goals;granule cell;Hippocampal Formation;Hippocampus;Homeobox;Homeodomain Proteins;Human;improved;In Vitro;in vivo;inhibitory neuron;innovation;Intervention;Intractable Epilepsy;Kainic Acid;Light;Lymphatic Research;medial temporal lobe;Memory;Modeling;Molecular Neurobiology;Morphology;mouse model;Mus;Nervous System Disorder;Neurons;neuropsychiatric disorder;neuroregulation;nonhuman primate;novel;novel strategies;Operative Surgical Procedures;Opsin;Organism;Outcome;Pathology;Patients;Plasmids;Play;Population;prevent;Primates;promoter;Protein Truncation;Proteins;Pyramidal Cells;receptor;Recurrence;Regulation;Regulatory Element;Resistance;Risk;Rodent;Seizures;selective expression;Sensitivity and Specificity;side effect;Signal Pathway;synthetic biology;Temporal Lobe;Temporal Lobe Epilepsy;Testing;Therapeutic;Transgenic Mice;Transgenic Organisms;translational potential;translational therapeutics;Validation;Viral Vector;Wild Type Mouse;Work

PROJECT_TITLE: Development and validation of a viral vector for targeted inhibition of DG granule cells

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


ED_INST_TYPE: OVERALL MEDICAL

NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Immunization;Women's Health Research

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: PROJECT NARRATIVE Antibody-drug conjugates (ADCs) are the most promising drug class for the treatment of triple-negative breast cancer (TNBC). However, further improvement is critically needed to benefit more patients with TNBC. The goal of this project is to generate novel ADCs with substantially improved efficacy and safety that can effectively eradicate a broad spectrum of solid and metastatic TNBC tumors.

PI_NAMEs: TSUCHIKAMA, KYOJI  (contact)

PROGRAM_OFFICER_NAME: FU, YALI

PROJECT_TERMS: Acceleration;Adjuvant Chemotherapy;Adverse effects;Affinity;Alkylating Agents;Antibodies;Antibody-drug conjugates;Antigens;Antimitotic Agents;Binding;Biodistribution;Biological Assay;Breast Cancer Cell;cancer cell;Cell Cycle;Cell Cycle Arrest;cell killing;Cell membrane;Cells;chemical property;Chemicals;Chemistry;Citrulline;Clinical;Colorectal Neoplasms;Data;Dependence;design;Diagnosis;Diffusion;Disease;DNA;Dose;drug candidate;Drug Kinetics;Drug resistance;Drug toxicity;Duocarmycin;effective therapy;Ensure;Enzymes;ERBB2 gene;Failure;FDA approved;Foundations;Gene Expression Profile;Glutamic Acid;Glycine;Goals;Grant;Hematology;Hepatotoxicity;Heterogeneity;improved;in vitro testing;in vivo;inhibitor;intravenous injection;Kinetics;Liver;liver injury;Lung Neoplasms;Malignant Breast Neoplasm;Malignant Neoplasms;mass spectrometric imaging;medication safety;Microtubules;Modality;Molecular Target;Morphology;mouse model;Mus;Neoadjuvant Therapy;Neutropenia;Normal Cell;novel;novel drug class;novel therapeutics;Organ;Outcome;overexpression;pancreatic neoplasm;Patient-derived xenograft models of breast cancer;Patients;Pattern;Peptide Hydrolases;Peptides;Pharmaceutical Preparations;Platinum;Population;Process;Proteins;Proteomics;Recurrence;Refractory;Relapse;Research;Resistance;Safety;Series;Serum;Site;SN-38;Solid;stemness;success;Surface Antigens;targeted treatment;Technology;Testing;Therapeutic;Therapeutic Index;Tissues;Toxic effect;Treatment Efficacy;Treatment Protocols;triple-negative invasive breast carcinoma;trophoblast;tumor;Valine;Work

PROJECT_TITLE: Antibody-dual drug conjugates for eradicating triple-negative breast cancer with heterogeneity

STUDY_SECTION: DMPC

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology C Study Section[DMPC]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Networking and Information Technology R&D (NITRD)

PI_NAMEs: MANCINI, MICHAEL A. (contact)

PROJECT_TERMS: analysis pipeline;anti-cancer research;Antibodies;Area;assay development;Award;Biological Assay;Cancer Center;Cancer Center Support Grant;cancer prevention;Cell Culture Techniques;Cell Cycle;Cells;Certification;college;Communities;Consultations;Core Facility;Custom;data acquisition;Data Analyses;Data Analytics;design;Digestive System Disorders;Dimensions;Educational process of instructing;Educational workshop;Experimental Designs;graduate student;Image;Image Analysis;imaging facilities;imaging informatics;Individual;informatics shared resource;Institution;instrument;instrumentation;Investments;Libraries;light microscopy;Medicine;member;Microscope;Microscopy;Miniaturization;Modeling;new technology;Phenotype;Proteins;Protocols documentation;Quality Control;Research;Research Institute;Research Personnel;Robotics;Sampling;screening;Services;Spottings;superresolution microscopy;symposium;Techniques;Technology;Texas;three dimensional cell culture;tissue culture;tool;Training;Training and Education;ultra high resolution;United States National Institutes of Health;Validation;Vendor

PROJECT_TITLE: Advanced Microscopy and Image Informatics


NIH_SPENDING_CATS: Biotechnology;Cancer

PI_NAMEs: ITTMANN, MICHAEL M (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Animal Model;Animals;anti-cancer research;Basic Science;biobank;Biological Assay;Blood;Cancer Center;Cancer Center Support Grant;Cancer Model;cancer specimen resource;cancer therapy;cell preparation;Clinical;clinical care;Clinical Data;Collaborations;Collection;college;Comprehensive Cancer Center;Consent;Consultations;Data;Databases;Development;DNA;Enrollment;Ensure;epidemiologic data;Epidemiology;Etiology;experience;follow-up;Formalin;Frozen Sections;Funding;Future;Genomics;histological stains;Histology;Histopathology;Hospitals;Human;Human Resources;human tissue;Image Analysis;Immunohistochemistry;in vivo;Informed Consent;Investigation;laser capture microdissection;Maintenance;Malignant Neoplasms;Medicine;metabolomics;Metagenomics;microbiome;mouse model;multidisciplinary;multiplexed imaging;National Cancer Institute;Normal tissue morphology;operation;optimal treatments;Paraffin Embedding;Pathologic;Pathologist;Pathology;patient derived xenograft model;Peripheral Blood Mononuclear Cell;Play;Population Research;Population Sciences;Prevention;programs;Proteomics;Questionnaires;Research;Research Activity;Research Personnel;Resource Sharing;Resources;Risk Factors;Role;Scanning;Science;Secure;Services;Slide;Specimen;Stains;Structure;Technology;Tissue Embedding;Tissue Microarray;tissue processing;Tissues;Training;transcriptomics;Translational Research;translational scientist;tumor;Urine;Venous blood sampling

PROJECT_TITLE: Integrated Biobanking Shared Resource


PI_NAMEs: LAPTEVA, NATALIA  (contact)

PROJECT_TERMS: Adenovirus Vector;Basic Science;Biological Testing;Cancer Center;Cancer Center Support Grant;cancer therapy;cell bank;Cell Therapy;Cells;Chemistry;Clinical;Clinical Research;Clinical Trials;college;Contracts;cost comparison;Data;Development;Disease;Documentation;early phase clinical trial;Environment;Environmental Monitoring;Equipment;experience;Flow Cytometry;follow-up;gene therapy;Genes;good laboratory practice;Good Manufacturing Process;Infrastructure;Investigational New Drug Application;Laboratories;Maintenance;manufacture;Medicine;National Heart, Lung, and Blood Institute;neoplastic;Phase I/II Clinical Trial;pre-clinical;preclinical study;Preparation;Procedures;Production;programs;Protocols documentation;quality assurance;Quality Control;Quality Indicator;Regulation;Research Personnel;research study;Resource Sharing;Resources;Retroviral Vector;Somatic Cell;Specific qualifier value;stability testing;Standard Preparations;System;Testing;Therapeutic;tissue repair;Training;Translations;United States Food and Drug Administration;Validation;vector;Viral Vector;Work

PROJECT_TITLE: Cell Processing and Vector Production


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Methamphetamine;Prevention;Sexually Transmitted Infections;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: CITY OF INDUSTRY

ORG_NAME: PUBLIC HEALTH FOUNDATION ENTERPRISES

ORG_STATE: CA

PHR: Project Narrative Injection drug use and methamphetamine use are increasing in the United States, as is the number of new HIV infections among this population. This randomized-controlled trial will compare video directly-observed treatment versus counseling for adherence to once-daily oral pre-exposure prophylaxis for prevention of HIV transmission among people who inject methamphetamine. Results among this high-risk population will contribute to ending the HIV epidemic.

PI_NAMEs: COFFIN, PHILLIP O (contact)

PROGRAM_OFFICER_NAME: JENKINS, RICHARD A

PROJECT_TERMS: Address;Adherence;adherence rate;Adult;Affect;aggressive therapy;AIDS prevention;arm;Attention;behavior change;Blood;Bupropion;Centers for Disease Control and Prevention (U.S.);Client satisfaction;Clinical Trials;Compensation;condoms;contingency management;Contracts;Counseling;Data;discontinuation study;Disease Outbreaks;Dose;Dryness;Effectiveness;efficacy evaluation;emtricitabine;Enrollment;Ensure;Epidemic;follow-up;Future;Habits;Health;high risk;high risk population;HIV;HIV Infections;HIV risk;HIV Seronegativity;implementation study;improved;Incentives;Infection;Injecting drug user;injection drug use;Injections;interest;Intervention;Interview;Libido;Life Style;Location;Measures;medication compliance;Methamphetamine;methamphetamine use;Methamphetamine use disorder;mobile application;Modeling;opioid epidemic;Oral;Outcome Measure;Participant;Pattern;Persons;pharmacologic;Population;pre-exposure prophylaxis;prevent;primary outcome;programs;Questionnaires;Randomized;Randomized, Controlled Trials;Recommendation;recruit;Reporting;Risk;Risk Assessment;Risk Behaviors;San Francisco;sexual HIV transmission;sexual risk behavior;Sexual Transmission;smartphone application;Spottings;Standardization;Stimulant;Surveys;Syringes;System;Telephone;Tenofovir;Testing;Time;time use;tool;transmission process;trial comparing;two-arm trial;United States;usability;Video Recording;Viral;Visit;willingness

PROJECT_TITLE: PRIME: PrEP Intervention for people who Inject MEthamphetamine