NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Mental Illness;Pain Research;Physical Activity;Post-Traumatic Stress Disorder (PTSD);Telehealth

ORG_CITY: BOSTON

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

ORG_STATE: MA

PHR: Project Narrative This research will produce valuable results that will guide the development of complementary approaches to posttraumatic stress disorder (PTSD) and chronic pain that are delivered remotely in Veteran populations. We will use the information obtained during this feasibility trial to develop a Tai Chi intervention that can be delivered over videoconference and will optimize the recruitment and retention of participants and , and an assessment protocol will be established that captures the most critical outcomes to ensure the success of future studies with this population. The ability to identify a novel, accessible, effective, safe and non- pharmacological first-line treatment will have a very high impact on quality of life for Veterans suffering from PTSD and chronic pain.

PI_NAMEs: MORI, DEANNA L.;NILES, BARBARA L. (contact);WANG, CHENCHEN

PROGRAM_OFFICER_NAME: MUDD, LANAY MARIE

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;Aerobic;Affect;Aftercare;barrier to care;Boston;Cardiovascular system;care seeking;Caring;Chinese;Chronic;chronic musculoskeletal pain;chronic pain;Clinical Trials;cohort;conditioning;cost;COVID-19;COVID-19 pandemic;Data;design;Development;Diagnosis;disability;Disease;effective therapy;efficacy evaluation;eligible participant;Ensure;Exercise;Feasibility Studies;feasibility trial;Feedback;flexibility;follow up assessment;follow-up;Future;global health;Goals;Health;Health care facility;Health Services Accessibility;Healthcare Systems;Home;improved;improved outcome;Integrative Therapy;Intervention;intervention delivery;Interview;Life;Measures;Memory;Mental disorders;Mental Health;Military Personnel;military veteran;Mind-Body Intervention;mind/body;Minority Participation;Muscle;Nonpharmacologic Therapy;novel;Outcome;Outcome Measure;Pain;Participant;participant retention;Patients;Perception;Phase;physical conditioning;Physical Function;Population;post intervention;Post-Traumatic Stress Disorders;Procedures;Protocols documentation;psychosocial;Public Health;Quality of life;Randomized;randomized trial;randomized, controlled study;recruit;remote delivery;Reporting;Research;satisfaction;Severities;Social Distance;Standardization;standardize measure;study population;success;symptom management;Symptoms;Tai Ji;Trauma;Travel;Treatment Protocols;United States Department of Veterans Affairs;Veterans;Veterans Health Administration;videoconference;Videoconferencing;Well in self;Woman

PROJECT_TITLE: Feasibility of Remote-Delivery Interventions: Tai Chi and Wellness for PTSD and Pain in Veterans


ADMINISTERING_IC: NS

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: NEW HAVEN

ORG_COUNTRY: UNITED STATES

ORG_DEPT: NEUROSURGERY

ORG_FIPS: US

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Intracranial aneurysms are balloon-like vascular dilations of the brain arteries that can rupture, leading to bleeding (hemorrhagic stroke) with catastrophic, often fatal, outcomes. Genetic predisposition is a risk factor for development and rupture of intracranial aneurysms. In the past fifteen years, we have conducted genetic studies that identified a number of candidate genes that confer susceptibility to intracranial aneurysm formation. Our proposal will validate new genetic findings we obtained by analyzing large families with multiple members over many generations presenting with intracranial aneurysms. We will use cellular and animal models to investigate the contributions of these candidate genes to the development of brain vessels, aiming to understand how they regulate blood vessel formation in the brain. We aim to understand how dysfunction of these genes disrupts brain blood vessel structure, understand in detail how specific cells in the brain vessels change as a consequence of the mutations we identified and the mechanisms that are involved, aiming to establish how this might contribute to the formation of intracranial aneurysms. The proposed research is relevant to public health because understanding brain blood vessel function and validating genes associated with intracranial aneurysms in families will help us elucidate disease pathogenesis as well as provide the necessary background to develop targeted therapeutic approaches in future studies.

PI_NAMEs: BARAK, TANYERI ;GUNEL, MURAT  (contact);LOUVI, ANGELIKI

PROGRAM_OFFICER_NAME: FOUNTAIN, JANE W

PROJECT_TERMS: 3-Dimensional;Address;Adult;Affect;Angiography;Animal Model;Animals;Arteries;Binding;Biochemical;blood vessel development;Blood Vessels;Brain;Brain hemorrhage;Candidate Disease Gene;Cell model;Cell Physiology;Cell Reprogramming;Cells;Central Nervous System;cerebral artery;Cerebral hemisphere hemorrhage;cerebrovascular;Cerebrovascular system;Cerebrum;Code;cohort;Complex;Data;Defect;Development;Diagnosis;Diagnostic;Disease;Endothelial Cells;Endothelium;Environmental Risk Factor;Etiology;Event;exome sequencing;experimental study;Family;Fluorescence Microscopy;Functional disorder;functional genomics;Future;Gene Expression Profiling;General Population;Generations;Genes;Genetic;Genetic Predisposition to Disease;genetic risk factor;Genetic study;Genetic Transcription;genome editing;genome wide association study;Genomic approach;Goals;Health;hemodynamics;Hemorrhage;Heterozygote;Histologic;Homeostasis;Human;improved;in vivo;Individual;Intracranial Aneurysm;Intracranial Hemorrhages;Knock-out;Left;Light;Long-Term Care;loss of function;Mediating;Medicine;member;microCT;model organism;Modeling;Molecular;Morbidity - disease rate;Morphology;mortality;mouse model;Mus;mutant;Mutation;Nature;Neurologic Deficit;novel;Organoids;Outcome;Pathogenesis;Pathogenicity;Pathologic;Pathway interactions;Patients;Phenotype;precision medicine;Predisposition;Prevalence;Proteins;Public Health;Reporter;Reporting;Research;Risk;Risk Factors;risk variant;Role;Rupture;Ruptured Aneurysm;senescence;Series;Stroke;Structure;Subarachnoid Hemorrhage;Survivors;targeted treatment;Testing;Therapeutic;Therapeutic Intervention;transcriptional reprogramming;Transgenic Organisms;Variant;Visualization;WNT Signaling Pathway;Work;Zebrafish

PROJECT_TITLE: Endothelial Cell Reprogramming in Familial Intracranial Aneurysm

STUDY_SECTION: BINP

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunotherapy;Infectious Diseases;Influenza;Lung;Lymphatic Research;Pneumonia and Influenza

ORG_CITY: PHILADELPHIA

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Organized collections of protective immune cells assemble in the lungs to fight infections from respiratory pathogens such as influenza virus. We will use innovative new genetic models to promote the formation of these clusters in healthy mice and will determine if this provides enhanced protection to subsequent influenza infection. Our studies will directly impact public health, as they will provide crucial insight for the design of novel therapeutics aimed at pre-emptively driving protective immune cell clusters in the lung.

PI_NAMEs: MAY, MICHAEL J (contact)

PROGRAM_OFFICER_NAME: JOFFE, AARON MICHAEL

PROJECT_TERMS: Address;Adult;Animals;Autoimmune;Autoimmune Diseases;Autoimmunity;Automobile Driving;Bacterial Infections;Body Weight;Body Weight decreased;Bronchus-Associated Lymphoid Tissue;CCL21 gene;cell assembly;cell motility;Cells;Characteristics;Chemotactic Factors;chronic inflammatory disease;cohort;Collection;Communicable Diseases;Complement;Data;Dendritic Cells;design;Disease;draining lymph node;Exhibits;fighting;Gene Expression;Gene Expression Profiling;Generations;Genes;Genetic Models;Goals;high risk;Homeostasis;IKK alpha;Immune;immune function;immune modulating agents;Immune response;Immunity;Immunologics;Immunotherapy;in vivo Model;Infection;Inflammation;Inflammatory;Inflammatory Response;Influenza;influenza infection;influenzavirus;innovation;insight;Knockout Mice;Lung;lung injury;lymph nodes;Lymphatic;Lymphatic Endothelial Cells;Lymphatic function;lymphatic vessel;Malignant Neoplasms;Methodology;Modeling;Mus;Nature;NF-kappa B;novel;novel therapeutics;Pathogenesis;Pathogenicity;Pathologic;Pathology;Pathway interactions;Peripheral;Phosphotransferases;Play;Population Heterogeneity;prevent;prophylactic;Public Health;Pulmonary Emphysema;pulmonary function;receptor;Research;respiratory infection virus;respiratory pathogen;Respiratory Tract Infections;response;Role;secondary lymphoid organ;Signal Transduction;single-cell RNA sequencing;Structure;Structure of parenchyma of lung;Tamoxifen;tertiary lymphoid organ;Testing;Therapeutic;therapeutic target;Tissues;Traction;vaccine efficacy;Viral;Virus Diseases;Weight

PROJECT_TITLE: Targeting IKK-alpha in lymphatics to drive protective tertiary lymphoid organ formation

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases;Rare Diseases;Vector-Borne Diseases

ORG_CITY: RIVERSIDE

ORG_DEPT: ZOOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA RIVERSIDE

ORG_STATE: CA

PHR: PROJECT NARRATIVE  Juvenile hormone is a lipophilic terpenoid hormone that controls development and reproduction in all insects, including human disease vectors such as mosquitoes. Although textbooks state that lipophilic hormones simply diffuse across cellular membranes, this simple diffusion model has never been established for any hormone in any organism. This project challenges the prevailing dogma in endocrinology and characterizes membrane transporters for juvenile hormone in mosquitoes, aiming to develop novel tools for controlling disease vector insects.

PI_NAMEs: YAMANAKA, NAOKI  (contact)

PROGRAM_OFFICER_NAME: COSTERO-SAINT DENIS, ADRIANA

PROJECT_TERMS: Adult women;Aedes;Arboviruses;Biological;Biological Assay;Biological Models;Biology;Carrier Proteins;Cell Line;Cell membrane;Cells;Cellular Membrane;Chemicals;Chikungunya virus;Circulation;combat;CRISPR/Cas technology;Culicidae;Cultured Cells;Cytoplasm;Data;Dengue Virus;Development;Diffuse;Diffusion;Disease Vectors;disorder control;Double-Stranded RNA;Drosophila genus;Drosophila melanogaster;Ecdysone;Endocrinology;Female;Genetic Techniques;Geographic Distribution;global health;Goals;Growth;hormone deficiency;Hormone Receptor;Hormones;Human;human disease;Hydrophobicity;In Vitro;in vivo;in vivo evaluation;inhibitor;Injections;insect disease vector;Insecta;Juvenile Hormones;knock-down;Lipid Bilayers;lipophilicity;Liposomes;loss of function;Luciferases;Mass Fragmentography;Mediating;Membrane;Membrane Transport Proteins;Methodology;Modeling;Molecular;Molecular Genetics;Mosquito Control;mosquito reproduction;Mutagenesis;mutant;Mutation;Names;novel;Organism;Orthologous Gene;Peripheral;pharmacologic;Phenocopy;Phenotype;Physiological;Physiology;Proteins;Quantitative Reverse Transcriptase PCR;Reagent;receptor;Reporter;Reproduction;Role;screening;solute;steroid hormone;Techniques;Terpenes;Textbooks;Thyroid Hormones;tool;trafficking;transcriptome sequencing;Travel;vector;Work;Yellow Fever;ZIKA

PROJECT_TITLE: Juvenile hormone transporters in disease vector physiology

STUDY_SECTION: VB

STUDY_SECTION_NAME: Vector Biology Study Section[VB]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Immunization;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases

ORG_CITY: COLUMBIA

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

ORG_STATE: MO

PHR: Narrative Yersinia pestis causes plague with high rates of mortality in the absence of immediate treatment. The current vaccine has had inherent limitations surrounding production as well as immune response. We have developed a vaccine that targets conserved proteins with an adjuvant that elicits humoral and cell-mediated immune responses.

PI_NAMEs: PICKING, WENDY L. (contact)

PROGRAM_OFFICER_NAME: MUKHOPADHYAY, SUMAN

PROJECT_TERMS: Adjuvant;animal data;Antibiotic Resistance;Antibiotics;Antibodies;Antigens;Area;Bacteria;bioweapon;Bubonic Plague;capsule;Case Fatality Rates;cell mediated immune response;Cells;Cessation of life;Classification;combat;cost;cytokine;Cytoplasm;Data;Death Rate;Disease;Disease Outbreaks;efficacy evaluation;enterotoxigenic Escherichia coli;enzootic;Formulation;Genetic;Health Hazards;high risk;Human;human pathogen;IL17 gene;Immune response;Infection;Intranasal Administration;Investigation;Methods;mouse model;mucosal site;Mus;mutant;Nature;Needles;Parents;pathogen;Pathogenesis;Pathogenicity;Plague;Pneumonic Plague;Predisposition;prevent;Production;protective efficacy;Proteins;Pseudomonas;Pseudomonas aeruginosa;Public Health;Reporting;Resources;response;Rodent;Route;Salmonella;Salmonella enterica;Septicemic plague;Shigella;Subunit Vaccines;System;Testing;Toxin;Type III Secretion System Pathway;United States;vaccine development;Vaccines;Virulence;Yersinia;Yersinia enterocolitica;Yersinia pestis

PROJECT_TITLE: Targeting T3SA proteins as protective antigens against Yersinia

STUDY_SECTION: VMD

STUDY_SECTION_NAME: Vaccines Against Microbial Diseases Study Section[VMD]


NIH_SPENDING_CATS: Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

ORG_STATE: NY

PHR: Development of the resident macrophage lineage in mouse and human Narrative Tissue-resident macrophages are essential supporting cells for organogenesis, tissue homeostasis and repair, and contribute to the pathogenesis of developmental, inflammatory, degenerative, and tumoral diseases. Understanding the cellular and molecular mechanisms that control their development and functions will provide insights into the mechanisms of these diseases and identify novel therapeutic strategies. Based on our preliminary results, and the tools we developed, our present project (renewal) aims to identify and characterize at the phenotypic, genetic, and functional level, the progenitors that give rise to resident macrophages in mice and human, and the mechanisms underlying their specification into tissue macrophages.

PI_NAMEs: GEISSMANN, FREDERIC  (contact)

PROGRAM_OFFICER_NAME: VAZQUEZ-MALDONADO, NANCY

PROJECT_TERMS: acquired factor;Address;Animal Model;bone;Brain;Cell Lineage;Development;Disease;Embryo;Embryoid bodies;Embryonic Development;Energy Metabolism;Erythro;Event;Face;Fatty acid glycerol esters;Funding;gastrulation;Genetic;Goals;Hematopoiesis;hematopoietic differentiation;Hematopoietic stem cells;Homeostasis;Human;human induced pluripotent stem cells;Impairment;improved;in vitro Model;in vivo;Individual;Inflammatory;insight;Investigation;Legal patent;Leukocytes;Lipids;Macrophage;Maintenance;Maps;Modeling;Molecular;mouse model;Mus;mutant;Mutation;Myeloid Progenitor Cells;Nature;Neurodegenerative Disorders;novel;novel therapeutic intervention;Organ;Organogenesis;Osteoclasts;Outcome;Pathogenesis;Patients;pharmacologic;Phenotype;Physiology;Population;postnatal;progenitor;programs;Progress Reports;Publications;repaired;Reporting;Resolution;Role;Science;Specific qualifier value;Supporting Cell;Therapeutic;Time;Tissues;tool;transcription factor;tumor;Vertebrates;Work;Yolk Sac;Zebrafish

STUDY_SECTION: CMIA

STUDY_SECTION_NAME: Cellular and Molecular Immunology - A Study Section[CMIA]


ADMINISTERING_IC: AG

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: BIRMINGHAM

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Project Narrative In order to fully address disparities in health status and outcomes in older adults, we must ensure that our research workforce in aging is representative of the full range of our population. Though our demographic landscape is changing, the research employment and NIH funding landscapes have changed little over the past several decades. The UAB Research in Aging through Mentorship and Practice – Undergraduate Program (UAB RAMP-UP) will provide mentored research training and education in MSTEM areas related to research in aging for undergraduate students from rural and diverse backgrounds underrepresented nationally in biomedical, behavioral, and clinical research, to help ensure that the process and products of scientific discovery are as robust as possible.

PI_NAMEs: FOUAD, MONA N. (contact)

PROGRAM_OFFICER_NAME: FU, YI-PING

PROJECT_TERMS: Address;Advocate;Aging;aging related;Alabama;Area;Attention;Behavioral Research;Biomedical Research;career;career development;career networking;Chronic Disease;Clinical Research;cohort;Country;Deep South;demographics;Disadvantaged;disparity reduction;Distance Learning;E-learning;Education;education research;Educational Activities;Employment;Ensure;ethnic minority;experience;Exposure to;Faculty;Funding;Future;Goals;graduate school;graduate school preparation;graduate student;Health;Health Disparities Research;health disparity;health inequalities;Health Personnel;Health Status;Historically Black Colleges and Universities;improved;Individual;innovation;Institution;instructor;interest;Journals;Learning;learning strategy;Literature;Maintenance;Mentors;Mentorship;Minority;minority health;minority health disparity;National Institute on Minority Health and Health Disparities;older adult;Outcome;Participant;Persons;Play;Population;Process;Productivity;programs;promoter;racial minority;Recording of previous events;Reduce health disparities;Reporting;Research;Research Personnel;research study;Research Training;Resources;Role;Rural;rural area;Rural Community;science, technology, engineering, mathematics, and medicine;Site;skills;social media;Structure;student participation;Students;success;summer research;synergism;Training;Training and Education;Training Programs;undergraduate student;Underrepresented Populations;Underrepresented Students;United States National Institutes of Health;Universities;Videoconferencing;virtual;virtual group;Virtual Tool;Work

PROJECT_TITLE: UAB Research in Aging through Mentorship and Practice - Undergraduate Program (UAB RAMP-UP)


ADMINISTERING_IC: HD

ED_INST_TYPE: GRADUATE SCHOOLS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_CITY: FORT COLLINS

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: COLORADO STATE UNIVERSITY

ORG_STATE: CO

PHR: PROJECT NARRATIVE The nucleus of the solitary tract (NTS), located in the brainstem, contains a heterogenous population of neurons that are implicated in both the inhibition of pulsatile LH secretion during stress and the facilitation of elevated LH secretion during the preovulatory LH surge. The objective of this work is to anatomically and functionally characterize individual NTS neuronal subpopulations in the regulation of LH secretion. Enhanced understanding of the diverse neural pathways that regulate LH secretion may provide a framework for developing therapies for amenorrhea, infertility, and stress-related reproductive disorders.

PI_NAMEs: MCCOSH, RICHARD BRYAN (contact)

PROGRAM_OFFICER_NAME: RAVINDRANATH, NEELAKANTA

PROJECT_TERMS: Ablation;Acetylcholine;Achievement;Address;Amenorrhea;Amygdaloid structure;Anatomy;Area;Bioinformatics;Brain;Brain imaging;Brain Stem;Cardiovascular system;career development;Cell Nucleus;Cells;Cholecystokinin;Coupled;Data;Data Set;Development;Diphtheria Toxin;Disease;Dynorphins;Ensure;Environment;Estradiol;experience;Female;Fertility;Future;Galanin;gamma-Aminobutyric Acid;Genetic;Glutamates;Goals;Gonadal Steroid Hormones;Gonadotropins;Hormone secretion;Hypothalamic structure;Individual;Infertility;Investigation;KISS1 gene;Knowledge;Label;Light;Location;Luteinizing Hormone;male;Mediating;Mental Health;Mentors;Microscopy;Mission;Musculoskeletal;neural;neural circuit;Neural Pathways;neural tract;Neuroanatomy;neurochemistry;neuroimaging;Neurokinin B;Neurons;neuropeptide Y;Neuropeptides;Neurotransmitters;next generation sequencing;Norepinephrine;novel;novel therapeutics;Nucleus solitarius;Optics;Ovarian Cycles;Pattern;Phase;Phenotype;Physiologic pulse;Physiological;Polycystic Ovary Syndrome;Population;Positioning Attribute;Production;programs;Protocols documentation;Regulation;reproductive function;reproductive system disorder;Research;Resources;response;Role;Scientist;Signal Transduction;single-cell RNA sequencing;Site;Somatostatin;steroid hormone receptor;Stress;Structure of area postrema;Structure of nucleus infundibularis hypothalami;Structure/Function Nuclei;success;Techniques;Technology;Testing;therapy development;Tissues;Training;training opportunity;transcriptomics;Transgenic Organisms;transmission process;United States National Institutes of Health;Vagus nerve structure;Ventricular;Viral;Visualization;Work

PROJECT_TITLE: Investigation of brainstem neurons in the regulation of gonadotropin secretion

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Diabetes

ORG_CITY: Nashville

ORG_DEPT: PHYSIOLOGY

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: Narrative:  G6PC2 encodes a glucose-6-phosphatase catalytic subunit (G6PC) isoform that is predominantly expressed in pancreatic islet beta cells. Published studies show that increased G6PC2 activity leads to elevated fasting blood glucose (FBG) levels, a parameter that influences the risk of cardiovascular- associated mortality and type 2 diabetes (T2D) and is also a key driver of complications in individuals with T2D. These observations strongly suggest that G6PC2 inhibitors represent a potential novel therapy to reduce FBG so the broad goals of the studies proposed in this application are to generate data that will foster the development of such inhibitors specifically by exploring the function (in Aim 1) and the structure and enzymology (in Aim 2) of G6PC2.

PI_NAMEs: O'BRIEN, RICHARD M (contact)

PROGRAM_OFFICER_NAME: SECHI, SALVATORE

PROJECT_TERMS: Address;adverse pregnancy outcome;Affect;Algorithms;Amino Acids;Atherosclerosis;Automobile Driving;B-Lymphocytes;Beta Cell;biobank;Biochemical;Biological Assay;Biology;Biophysics;Blood Glucose;Calcium Oscillations;cardiovascular risk factor;Cardiovascular system;Catalysis;Catalytic Domain;Cell Physiology;Cells;cerebral atrophy;Complications of Diabetes Mellitus;Data;Development;Diabetes Mellitus;diabetic;Endoplasmic Reticulum;Enzymatic Biochemistry;enzyme activity;Enzymes;Failure;Fasting;fasting blood glucose level;Fostering;Functional disorder;Futile Cycling;G6PC2 gene;G6PC3 gene;Genetic;Genotype;Glucokinase;Glucose;glucose-6-phosphatase;Glucose-6-Phosphate;Glucosephosphates;Glycolysis;Goals;Health;Heart Diseases;Human;Hydrolysis;Hyperglycemia;Impairment;In Vitro;in vitro activity;Incidence;Individual;inhibitor;inorganic phosphate;insight;insulin secretion;Intestines;Investigation;islet;Islets of Langerhans;Kidney;Link;Liver;Measurement;Measures;Medical;Membrane;Metabolic;Metabolic Pathway;Methodology;Molecular;molecular modeling;molecular scale;mortality;Mutagenesis;non-diabetic;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutic intervention;novel therapeutics;Patients;Phenotype;Physiological;Prediabetes syndrome;prediction algorithm;Prevention;prophylactic;Protein Isoforms;protein structure prediction;Protocols documentation;Publications;Publishing;rational design;Regulation;Resolution;Risk;Role;Single Nucleotide Polymorphism;Specificity;structural biology;Structure;Therapeutic;Whole Organism

PROJECT_TITLE: G6PC Enzymology, Structure, Function and Role in the Regulation of Fasting Blood Glucose

STUDY_SECTION: BMDM

STUDY_SECTION_NAME: Basic Mechanisms of Diabetes and Metabolism Study Section[BMDM]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Neurodegenerative;Neurosciences;Urologic Diseases;Women's Health Research

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE This research is designed to provide rigorous evidence about the effects of widely used medications for urgency urinary incontinence on cognitive function in older women. Findings will help guide counseling and decision-making for the millions of older incontinent women in the U.S. who must weigh the functional tradeoffs of using these medications to preserve their day-to-day functioning and ability to live independently.

PI_NAMEs: HUANG, ALISON  (contact)

PROGRAM_OFFICER_NAME: NELLISSERY, MAGGIE JACOB

PROJECT_TERMS: Acceleration;Address;Adrenergic Agents;Adverse effects;Age;Agonist;Alzheimer's disease related dementia;Anti-Cholinergics;Behavioral;Bladder;Bladder Control;Chronic;Cognition;Cognitive;cognitive function;cognitive performance;cognitive testing;Communities;comorbidity;comparative;Confusion;Counseling;Data;Decision Making;Dementia;design;Detection;Diagnosis;Double-blind trial;Drug Prescriptions;Equilibrium;Evaluation;evidence base;experience;falls;Fracture;Frequencies;functional decline;functional outcomes;Health care facility;Impaired cognition;improved;improvement on sleep;Incontinence;Independent Living;Industry;Intestines;Investigation;Link;Long-Term Care;Measures;Mental Depression;Methodology;micturition urgency;mild cognitive impairment;neglect;Observational Study;older adult;older patient;older women;Outcome;Overactive Bladder;Participant;Patients;Performance;Pharmaceutical Preparations;pharmacologic;Pharmacological Treatment;Pharmacotherapy;Physical Function;Placebos;preservation;prospective;psychologic;Quality of life;Randomized;Reporting;Research;Risk;screening;Severities;Sleep;Social isolation;Symptoms;System;Testing;Tolterodine;treatment effect;treatment strategy;trend;United States;urinary;Urinary Incontinence;Woman

PROJECT_TITLE: Cognitive, urinary, and functional trajectories of older women using pharmacologic treatment strategies for urgency incontinence

STUDY_SECTION: ASG

STUDY_SECTION_NAME: Aging Systems and Geriatrics Study Section[ASG]


ADMINISTERING_IC: GM

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: CLEVELAND

ORG_DEPT: PATHOLOGY

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative: The Case Western Reserve University MSTP will develop MD-PhD training to train a diverse pool of physician- scientists to meet future needs for research leaders who can accelerate research to advance the understanding, detection, treatment and prevention of human disease. We will develop an MD-PhD curriculum that integrates research and clinical training in a manner that deeply engages research training from the beginning of the program to promote retention of trainees in the research mission and foster curricular efficiency in time to completion of MD-PhD training. The integrated research and clinical curriculum, program activities, DEI focus and activities, and support for students will produce a highly skilled and diverse physician- scientist workforce, which will contribute to national goals for basic, translational and clinical research in academia, government and industry.

PI_NAMEs: BROIHIER, HEATHER ;HUANG, ALEX YEE-CHEN (contact)

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TITLE: Medical Scientist Training Program at Case Western Reserve University

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - A[TWD-A]


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

ORG_CITY: ROCHESTER

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: There is a great societal need for physician-scientists who work at the interface of clinical patient care and scientific investigation. The MSTP at the University of Rochester equips future physician-scientists with an in- depth understanding of medicine and a rigorous research experience, allowing them to pursue careers that fill important positions in academic medicine and translate research discoveries to improve health.

PI_NAMEs: O'BANION, M. KERRY (contact)

PROGRAM_OFFICER_NAME: NELSON, SHAKIRA M

PROJECT_TITLE: University of Rochester Medical Scientist Training Program


ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative The quickening pace of scientific discovery demands a new generation of physician-scientists who can understand the languages that are spoken both in the research setting and at the bedside. Our plan is to provide rigorous scientific and clinical training in a safe and inclusive environment to train MD-PhD Physician-Scientists. Using this knowledge, these individuals will be ideally positioned to make significant contributions to and improvements in human health, and thereby become the next generation of leaders in biomedical science.

PI_NAMEs: DARVILLE, TONI ;DESHMUKH, MOHANISH P (contact)

PROGRAM_OFFICER_NAME: AKACEM, LAMEESE DANA

PROJECT_TERMS: Medical;Scientist;Training Programs

PROJECT_TITLE: UNC Medical Scientist Training Program


ADMINISTERING_IC: ES

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Endocrine Disruptors;Infectious Diseases;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn

ORG_CITY: DETROIT

ORG_DEPT: MISCELLANEOUS

ORG_NAME: WAYNE STATE UNIVERSITY

ORG_STATE: MI

PHR: PROJECT NARRATIVE We hypothesize that pollutant exposures can increase the susceptibility to bacterial infection and increase preterm birth risk. Results from our mechanistic studies will identify critical pathways responsible for preterm birth and establish a causative link between pollutant exposures and adverse birth outcomes.

PI_NAMEs: PETRIELLO, MICHAEL CURTIS (contact)

PROGRAM_OFFICER_NAME: SCHUG, THADDEUS

PROJECT_TERMS: Adult;adverse birth outcomes;Affect;Attention;Award;Bacteria;Bacterial Infections;Benign;Biochemical;Bioinformatics;Birth;Cardiovascular system;Carpet;Cells;Chemicals;Chemistry;Chronic Disease;Clothing;Coupling;Critical Pathways;design;Down-Regulation;Environment;Environmental Pollutants;Epidemiology;exposed human population;Exposure to;Fetal Growth;Fetal Growth Retardation;fire fighter;Genomics;Glycoproteins;glycoproteomics;glycosylation;Goals;Health;Hemorrhage;Hepatic;Human;Immunoglobulin G;immunoregulation;Immunosuppressive Agents;In Vitro;in vivo;Incidence;Individual;Infection;Inflammation;Inflammatory;Inflammatory Response;Institution;Interferon Activation;Interferon-beta;Interferons;Label;Lead;Link;man;Maternal Exposure;Measures;Mediating;Mediator;Metabolic;Methods;Modeling;Monitor;Mus;National Institute of Child Health and Human Development;novel;Outcome;Output;Pathway interactions;Pattern;Perinatology;Placenta;Placental Toxicity;Play;pollutant;Poly-fluoroalkyl substances;Polysaccharides;Post-Translational Protein Processing;pre-clinical;Predisposition;Pregnancy;pregnant;Premature Birth;Property;protein biomarkers;Protein Glycosylation;Proteins;Reaction;receptor;Regulation;Reporter;Reporting;Reproducibility;Research;Research Personnel;Resolution;response;Risk;Role;Severities;Signal Transduction;Site;Slide;Spatial Distribution;stressor;sugar;surfactant;Techniques;Testing;tool;Toxicant exposure;transcriptome;trophoblast;TYRO3 gene;United States National Institutes of Health;Universities;Viral;Visualization;Wild Type Mouse;Work

PROJECT_TITLE: PFAS increases susceptibility to infection-mediated PTB

STUDY_SECTION: PN

STUDY_SECTION_NAME: Pregnancy and Neonatology Study Section[PN]


ADMINISTERING_IC: HG

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_CITY: CAMBRIDGE

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: HARVARD UNIVERSITY

PHR: Project Narrative FlyBase provides a crucial centralized resource for Drosophila genetic and genomic data to enable researchers both in the Drosophila community and broader biomedical sciences community to further their research. Drosophila is one of the premier model organisms and provides cost-effective help in elucidating the etiology of human genetic diseases. We will work closely with other Model Organism Databases (MODs) of the Alliance for Genomic Research (The Alliance) to integrate data sets and develop tools to enable cross-species analyses and expedite development of Drosophila human disease models.

PI_NAMEs: PERRIMON, NORBERT  (contact)

PROGRAM_OFFICER_NAME: XIRASAGAR, SANDHYA

PROJECT_TERMS: Acceleration;Atlases;Biology;Brain;Cells;Clinical;Collaborations;Communities;computer scientist;Controlled Vocabulary;cost effective;Data;data integration;Data Set;Databases;Development;Development Plans;Disease;disease model;Drosophila genus;Drosophila melanogaster;Ecosystem;Etiology;fly;FlyBase;functional genomics;Funding;Future;Genes;Genetic;Genetic Databases;Genetic Diseases;genome annotation;genome resource;genomic data;Genomics;Goals;Health;Human;human data;human disease;Human Genetics;human model;improved;International;Laboratory Research;Literature;member;model organism;model organisms databases;mutant;National Human Genome Research Institute;Ontology;Paper;Process;Research;Research Personnel;Resource Development;Resources;Science;Scientist;Site;Site Visit;synergism;Time;tool;transcriptomics;Transgenic Organisms;virtual;Visual;web portal;web site;Work

PROJECT_TITLE: FlyBase: A Drosophila Genomic and Genetic Database

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BBBT-T (55)]


NIH_SPENDING_CATS: Neurosciences

ORG_CITY: ANN ARBOR

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: Narrative Relevance to Public Health Physician-neuroscientists bring indispensable skills to disease-oriented research and facilitate the integration of research and clinical practice. This program will improve the supply of physician-neuroscientists starting independent research careers.

PI_NAMEs: ALBIN, ROGER L (contact)

PROGRAM_OFFICER_NAME: WEIGAND, LETITIA ALEXIS

PROJECT_TERMS: Address;American;career;career development;Clinical;clinical practice;Clinical Research;clinical training;Communities;Development;Discipline;Disease;Doctor of Philosophy;early experience;Environment;Exhibits;experience;Fellowship;Fellowship Program;Functional disorder;Goals;graduate school;improved;Individual;matriculation;medical schools;Mentors;Michigan;Nervous System Disorder;Nervous System Physiology;Neurology;neuropathology;Neurosciences;Neurosciences Research;neurosurgery;Pathogenesis;Pathology;Pediatric Neurology;Physicians;pre-clinical research;Productivity;programs;Public Health;Public Health Schools;Research;Research Activity;Research Personnel;Research Training;Residencies;Resource Development;skills;Structure;Talents;Training;Training Programs;translational pipeline;Translational Research;Translations;Universities

PROJECT_TITLE: UM Clinical Neuroscientist Training Program

STUDY_SECTION_NAME: Special Emphasis Panel[ZNS1 SRB-B (03)]


ORG_CITY: POCATELLO

ORG_DEPT: BIOLOGY

ORG_NAME: IDAHO STATE UNIVERSITY

ORG_STATE: ID

PHR: Narrative The proposed program is relevant to public health because it contributes to the development of scientific human resources that will ensure the Nation's capability to prevent disease by graduating students who embark on biomedical careers. The program is relevant to NIAID’s mission because it contributes to a diverse and inclusive workforce by recruiting and preparing participants from underrepresented groups. Upon conclusion, the program will have trained dozens of participants who would likely have not completed college.

PI_NAMEs: GRINATH, ANNA STRIMAITIS;HILL, CYNTHIA ;THOMAS, MICHAEL ALLEN (contact)

PROGRAM_OFFICER_NAME: MOTEN, CARMEN

PROJECT_TERMS: Address;Bacteriophages;Bioinformatics;Biological Models;Biomedical Research;biomedical scientist;career;Career Choice;cohort;college;Communities;Community Health Education;coronavirus pandemic;Curiosities;Development;Disease;Diverse Workforce;education research;Ensure;Face;financial incentive;Funding;Future;future pandemic;Generations;Goals;graduate student;Grant;Health;Human;Human Resources;Idaho;Income;Institution;interest;Investments;K-Series Research Career Programs;Knowledge;Learning;Location;member;Mentors;Mission;National Institute of Allergy and Infectious Disease;next generation;Outcome;Participant;Pathway interactions;Persons;prevent;Program Efficiency;programs;Public Health;recruit;Research;Research Personnel;Resources;Role;Rural;Scientist;Self Perception;skills;Students;Talents;Training;undergraduate student;Underrepresented Populations;Underrepresented Students;Underserved Population;Universities;university student;Work;workforce needs

PROJECT_TITLE: ISU Bridges to Research Careers

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 TC-D (S1)]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Overall Narrative The Masonic Cancer Center is an NCI-Designated Comprehensive Cancer Center that creates a collaborative research environment focused on the causes, prevention, detection, and treatment of cancer; applying that knowledge to improve quality of life for patients and survivors; and sharing its discoveries with other scientists, students, professionals, and the community.

PI_NAMEs: YEE, DOUGLAS  (contact)

PROGRAM_OFFICER_NAME: ROBERSON, SONYA

PROJECT_TERMS: Address;anti-cancer research;base;Basic Science;Cancer Burden;Cancer Center;Cancer Center Support Grant;cancer clinical trial;cancer risk;Cancer Survivorship;cancer therapy;carcinogenesis;Caring;Catchment Area;Cell Therapy;Cells;Chemoprevention;Clinical Research;Clinical Trials Network;Collaborations;college;Communities;community engagement;Complex;Comprehensive Cancer Center;Dedications;Detection;Developmental Therapeutics Program;Education;Environment;Etiology;Faculty;First Independent Research Support and Transition Awards;Funding;Genetic;Grant;Growth;Immigrant;Immunology;Immunotherapy;improved;innovation;Institute for Cancer Prevention;Interdisciplinary Study;International;Intervention Trial;Knowledge;Leadership;Malignant Neoplasms;member;Minnesota;next generation;outreach;Pathway interactions;Patient Care;patient population;Patients;Play;Population;Population Heterogeneity;Population Research;Prevention;programs;Publications;Quality of life;quality of life for cancer survivors;Research;Research Activity;Research Personnel;Resource Sharing;Resources;Role;Rural Population;Schools;Science;Scientist;screening;Structure;Students;success;Survivors;Textiles;Time;tobacco control;Training;translational pipeline;Translational Research;Translations;transplantation therapy;Twin Cities;Underrepresented Populations;Underserved Population;Universities;University of Minnesota Cancer Center;Vision;working group

PROJECT_TITLE: Cancer Center Support Grant

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


NIH_SPENDING_CATS: Cancer

PI_NAMEs: SCHILZ, AARON  (contact)

PROJECT_TERMS: Accountability;anti-cancer research;Area;Automobile Driving;Award;base;Basic Science;Budgets;cancer care;Cancer Center;Cancer Center Support Grant;cancer clinical trial;cancer therapy;Catchment Area;Clinic;Clinical;Clinical Research;Clinical Trials;Clinical Trials Network;Collaborations;college;Communication;Communities;community clinic;Community Clinical Oncology Program;community engagement;Community Outreach;Consultations;Data;Decision Making;Development;Developmental Therapeutics Program;Diverse Workforce;Education;Employee;Ensure;Equity;equity, diversity, and inclusion;Evaluation;Faculty Recruitment;Fostering;Funding;Future;Goals;Grant;Growth;Growth and Development function;Health;Health Care Research;Health system;Home;Human Resources;Individual;Infrastructure;innovation;Institution;Investments;Lead;Leadership;Malignant Neoplasms;Marketing;Mayo Clinic Cancer Center;Medical center;member;Minnesota;Mission;Monitor;NCI Center for Cancer Research;Network Infrastructure;next generation;Occupational activity of managing finances;operation;Organizational Affiliation;organizational structure;outreach;Performance;Population Research;Process;Program Evaluation;programs;Reporting;Research;research and development;Research Institute;Research Personnel;Research Priority;Research Support;Resource Sharing;Resources;Role;Science;Services;Site;Socialization;Strategic Planning;Structure;symposium;tool;Training and Education;Translational Research;Translations;United States Department of Veterans Affairs;Universities;University of Minnesota Cancer Center;Vision

PROJECT_TITLE: Cancer Center Administration


NIH_SPENDING_CATS: Cancer;Pediatric

PI_NAMEs: PENNELL, CHRISTOPHER A (contact)

PROJECT_TERMS: Active Learning;Address;anti-cancer research;Applications Grants;Cancer Burden;Cancer Center;Cancer Center Support Grant;cancer clinical trial;cancer education;cancer initiation;career;career development;Certification;Clinical;Clinical Sciences;Clinical Trials;collaborative environment;Communication;Communities;community based participatory research;community college;community engagement;community organizations;Community Outreach;Development;Development Plans;Doctor of Philosophy;doctoral student;Education;education resources;Educational Grants;Educational process of instructing;Educational workshop;Endowment;Equipment;equity, diversity, and inclusion;evidence base;experience;Faculty;faculty community;Fostering;Funding;Future;Goals;graduate student;Grant;Health Disparities Research;Health equity research;high school;High School Student;Immunology;improved;Individual;innovation;laboratory experience;Leadership;Libraries;Malignant Neoplasms;Manuscripts;Medicine;member;Mentors;Minnesota;NCI Center for Cancer Research;Not Hispanic or Latino;operation;Oral;Participant;peer coaching;peer networks;people of color;Population Heterogeneity;Postdoctoral Fellow;posters;pre-doctoral;Preparation;programs;Provider;Recording of previous events;recruit;Research;Research Personnel;Research Project Grants;Resources;Schools;Science;senior faculty;Shapes;skills;social;Special needs;Specialist;Students;success;Time;Training;Training and Education;Training Programs;Translational Research;undergraduate student;Underrepresented Populations;Universities

PROJECT_TITLE: Cancer Research Training and Education Coordination


PI_NAMEs: GHEBRE, RAHEL G (contact)

PROJECT_TERMS: Address;anti-cancer research;Area;Awareness;Benchmarking;Cancer Center;Cancer Center Support Grant;Cancer Survivorship;career;career development;Career Mobility;Catchment Area;Categories;Collaborations;Communities;community engagement;Community Medicine;Community Outreach;dashboard;Data;Development;diversity and equity;Employee;Ensure;Environment;Equity;equity, diversity, and inclusion;Etiology;Evaluation;experience;Faculty;Fellowship;Gender;gender equity;Goals;Gynecologic Oncologist;higher education;improved;Individual;Institution;Internships;Intervention;Leadership;leadership development;Malignant Neoplasms;Measures;medical schools;Medicine;member;Mentors;Minnesota;NCI Center for Cancer Research;next generation;Oncology;Operative Surgical Procedures;Outcome;parity;Pathway interactions;Persons;Population;Population Heterogeneity;Postdoctoral Fellow;Prevention;Professional Organizations;professor;Program Development;programs;psychologic;recruit;Recruitment Activity;Research;Research Personnel;Resources;Safety;Science;screening;Structure;success;System;Talents;Teacher Professional Development;Training and Education;Training Programs;Underrepresented Populations;Universities;Work

PROJECT_TITLE: Plan to Enhance Diversity


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Digestive Diseases;Genetics;Hematology;Human Genome;Lung;Lung Cancer;Lymphatic Research;Lymphoma;Orphan Drug;Prevention;Rare Diseases;Tobacco;Tobacco Smoke and Health

PI_NAMEs: PETERSON, LISA A (contact)

PROJECT_TERMS: Acceleration;Affect;Analytical Biochemistry;Award;Basic Science;Biochemical Pathway;Biological Markers;biomarker development;Biometry;Blood;Body of uterus;Breast;burden of illness;cancer biomarkers;Cancer Burden;Cancer Center;Cancer Center Support Grant;cancer genomics;cancer prevention;cancer risk;Carcinogen exposure;carcinogenesis;Carcinogenesis Mechanism;care providers;Catchment Area;Chemicals;Chemoprevention;Clinical Chemoprevention;Clinical Research;Clinical Trials;Clinical Trials Network;cohort;Collaborations;college;Colorectal Cancer;Communities;community engagement;Community Outreach;Comparative Pathology;Cystic Fibrosis;Data;Development;Devices;Doctor of Philosophy;Environment;Environmental Exposure;epidemiology study;experience;exposure pathway;Exposure to;Faculty;Family Study;Fanconi's Anemia;Food;Funding;Future;Goals;Grant;Head and Neck Cancer;Health Hazards;Hematopoietic Neoplasms;High-Risk Cancer;Individual;Institute for Cancer Prevention;Institution;inter-institutional;Lead;Leadership;leukemia/lymphoma;Link;Lung;malignant mouth neoplasm;Malignant neoplasm of lung;Malignant neoplasm of pancreas;Malignant neoplasm of prostate;Malignant neoplasm of urinary bladder;Malignant Neoplasms;meetings;Melanoma;member;microbiome;Minnesota;Molecular;National Cancer Institute;Nicotine;Non-Hodgkin's Lymphoma;novel;Patients;Population;Preclinical Drug Development;Predisposition;prevent;Prevention;Prevention program;Prevention strategy;Productivity;Program Development;programs;Public Policy;Publications;recruit;Research;Research Project Grants;Research Support;Resource Sharing;Resources;Risk;risk stratification;Schools;Science;Shapes;Smoker;smoking cessation;Strategic Planning;Structure;success;symposium;synergism;Techniques;Therapeutic;Tobacco;tobacco regulation;tool;Translational Research;Translations;treatment strategy;Universities;vulnerable community;Work;working group

PROJECT_TITLE: Carcinogenesis and Chemoprevention


NIH_SPENDING_CATS: Cancer;Genetics

PI_NAMEs: SCHWERTFEGER, KATHRYN L (contact)

PROJECT_TERMS: Affect;Architecture;Area;autocrine;Basic Science;bench to bedside;Biological Markers;biomarker identification;biomechanical test;Biophysics;cancer cell;Cancer Center;Cancer Center Support Grant;cancer stem cell;Cell Adhesion;cell growth;Cell membrane;cell motility;cell type;Cells;Clinic;Clinical;Clinical Trials;clinically significant;Collaborations;college;Communication;Complex;cytokine;Cytoskeletal Modeling;Development;Disease;Disease Progression;Disease Resistance;Doctor of Philosophy;drug development;Drug usage;early detection biomarkers;Epigenetic Process;epigenome;Extracellular Matrix;Funding;Gene Expression;Gene Expression Regulation;Genes;Genetic Transcription;genome-wide;Goals;Grant;Growth Factor;Hormones;Imaging technology;In Vitro;in vivo;innovation;Intervention;Invaded;Knowledge;Laboratories;Lead;Maintenance;Malignant - descriptor;Malignant Neoplasms;member;Metabolism;migration;Molecular;Neoplasm Metastasis;neoplastic cell;new therapeutic target;novel;novel strategies;novel therapeutic intervention;novel therapeutics;Oncogenic;Paper;paracrine;Pharmaceutical Chemistry;Phenotype;Pilot Projects;posttranscriptional;programs;protein complex;Protein Kinase;protein phosphatase inhibitor-2;Publishing;Research;Resistance;Resource Sharing;Schools;sensor;Signal Pathway;Signal Transduction;Signal Transduction Pathway;Signaling Molecule;small molecule;steroid hormone;Steroid Receptors;Stimulus;Stromal Cells;Stromal Change;Stromal Neoplasm;Structure;targeted treatment;therapy development;therapy resistant;Transcriptional Regulation;translational cancer research;Translational Research;tumor;Tumor Cell Biology;tumor diagnosis;tumor growth;tumor microenvironment;tumor progression;Tumor Promotion;tumorigenic;Work;working group

PROJECT_TITLE: Cellular Mechanisms


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Gene Therapy;Genetics;Human Genome;Immunotherapy

PI_NAMEs: YAMAMOTO, MASATO  (contact)

PROJECT_TERMS: Administrative Supplement;Adoptive Immunotherapy;Aftercare;Animal Model;Antineoplastic Agents;Area;Basic Science;Bioinformatics;Biological Sciences;Budgets;cancer cell;Cancer Center;Cancer Center Support Grant;Cancer Etiology;cancer genome;cancer genomics;cancer stem cell;cancer therapy;carcinogenesis;Cell Therapy;Cells;Cellular immunotherapy;Chemoresistance;chemotherapy;Clinic;Clinical;clinical translation;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;college;Combined Modality Therapy;comparative;Cyclic GMP;Development;Direct Costs;DNA Damage;DNA Repair Disorder;Doctor of Philosophy;drug repurposing;Drug resistance;Engineering;Evolution;Faculty;FDA approved;Flow Cytometry;functional genomics;Funding;gene discovery;gene therapy;Gene Transfer;Genetic;genetic information;genetically engineered virus;genome analysis;genome editing;Genome engineering;Genomic Instability;Goals;Homeostasis;homologous recombination deficiency;Immunology;immunotherapeutic virotherapy;improved;Informatics;inter-institutional;interest;International;Intervention;Malignant Neoplasms;Mediating;medical schools;member;minority investigator;Molecular;mouse genetics;Mutagenesis;Mutagens;Mutation;National Cancer Institute;Natural Killer Cells;Normal tissue morphology;novel therapeutics;Obesity;Oncogenes;oncolytic adenovirus;oncolytic virotherapy;Oncolytic viruses;Operative Surgical Procedures;Paper;Pathway interactions;Pharmaceutical Preparations;Pharmacy Schools;Phase;Physicians;Pilot Projects;Poly(ADP-ribose) Polymerase Inhibitor;pre-clinical;Production;programs;Public Health Schools;Publishing;recruit;repaired;replication stress;Research;Resistance;Resource Sharing;Resources;School Dentistry;Schools;Science;Scientist;senior faculty;Solid Neoplasm;success;Technology Transfer;Therapeutic;therapy resistant;tool;Translating;translational cancer research;translational goal;translational therapeutics;Translations;transplantation therapy;tumor;tumor heterogeneity;tumor initiation;tumorigenesis;Twin Cities;Underrepresented Minority;Variant;Veterinary Medicine;Viral;Virotherapy;Virus;Work;working group

PROJECT_TITLE: Genetic Mechanisms


NIH_SPENDING_CATS: Cancer;Immunotherapy

PI_NAMEs: MILLER, JEFFREY S. (contact)

PROJECT_TERMS: Acceleration;Activated Natural Killer Cell;Address;Advanced Malignant Neoplasm;anti-tumor immune response;Autoimmunity;Automobile Driving;Basic Science;Blood;Budgets;Cancer Center;Cancer Center Support Grant;cancer immunotherapy;Cancer Model;Cancer Patient;cancer therapy;cancer type;CAR T cell therapy;Catchment Area;Cells;Center for Translational Science Activities;Chronic Disease;Clinic;Clinical;clinical application;clinical efficacy;clinical trial enrollment;Collaborations;college;community engagement;Community Outreach;Development;Direct Costs;Doctor of Philosophy;Education;Environment;Event;Faculty;Fostering;Foundations;Funding;Generations;Grant;Health Professional;high school;Immune;immune checkpoint blockade;Immune response;Immune system;immune system function;Immune Targeting;Immune Tolerance;Immunity;Immunologic Memory;Immunology;Immunotherapy;insight;Intervention;Journals;Lead;Leadership;Link;Longevity;Malignant neoplasm of pancreas;Malignant Neoplasms;Mediating;meetings;member;mouse model;Myeloid Cells;National Cancer Institute;Nature;neurotoxicity;novel;Paper;Patients;pre-clinical;Pre-Clinical Model;Process;professional students;programs;Publications;Publishing;Regulation;Research;Research Activity;research clinical testing;Research Personnel;Resistance;Resource Sharing;Role;Schools;Scientific Advances and Accomplishments;side effect;Specificity;Strategic Planning;success;synergism;T-Lymphocyte;tissue resident memory T cell;Training;Training Support;Translating;Translation Process;translational cancer research;translational immunology;tumor;undergraduate student;United States National Academy of Sciences;United States National Institutes of Health;Work;working group

PROJECT_TITLE: Immunology


NIH_SPENDING_CATS: Aging;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Hematology;Lung;Lung Cancer;Prevention;Tobacco

PI_NAMEs: NELSON, HEATHER HAMMOND (contact)

PROJECT_TERMS: Address;Aging;Analytical Biochemistry;anti-cancer research;Basic Science;Biological Markers;Biometry;Budgets;Cancer Center;Cancer Center Support Grant;Cancer Control;cancer epidemiology;cancer health disparity;cancer prevention;Cancer Survivor;Cancer Survivorship;career;Catchment Area;Clinical;Collaborations;community engaged research;community engagement;Community Health;Community Outreach;Data;Data Analyses;design;Direct Costs;Disparity;Doctor of Philosophy;Early Diagnosis;environment related cancer;Environmental Exposure;Epidemiologist;Epidemiology;epidemiology study;Etiology;Foundations;Funding;Future;Guidelines;Harm Reduction;Health;health equity;Hematologic Neoplasms;Hematology;high risk population;Human Papilloma Virus Vaccination;improved;informatics shared resource;innovation;interest;Intervention;Intervention Trial;Investments;Knowledge;Laboratories;Leadership;life span;Link;Malignant Childhood Neoplasm;Malignant Neoplasms;medical schools;meetings;Melanoma;member;Mentors;National Cancer Institute;novel;novel strategies;Oncology;Outcome;Pilot Projects;Policies;Population;population based;prevent;Prevention;professor;Prognosis;programs;Public Health Schools;Quality of life;Research;Research Personnel;Research Support;research to practice;Resource Sharing;Risk;Risk Reduction;school health;Schools;Scientist;screening;Screening for cancer;Special Population;survivorship;Tobacco;tobacco products;Tobacco use;Training;Translating;Transplantation;Work

PROJECT_TITLE: Screening, Prevention, Etiology, and Cancer Survivorship


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Gene Therapy;Genetics;Hematology;Immunotherapy;Orphan Drug;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

PI_NAMEs: WAGNER, JOHN E. (contact)

PROJECT_TERMS: Acceleration;Acute Graft Versus Host Disease;Address;Allogenic;Allografting;Autologous;Biological Sciences;Blood;Bone Marrow Transplantation;Budgets;Cancer Burden;cancer care;Cancer Center;Cancer Center Support Grant;cancer clinical trial;cancer therapy;Cell Therapy;Cells;Cellular immunotherapy;chimeric antigen receptor;chronic graft versus host disease;Clinic;Clinical;Clinical Investigator;Clinical Sciences;Clinical Trials;Clinical Trials Network;Collaborations;college;Communities;Complex;conditioning;Contracts;cost;cytokine release syndrome;Development;Direct Costs;Disease remission;Dose;early phase clinical trial;Effector Cell;Engineering;exhaustion;experience;first-in-human;Flow Cytometry;Funding;Future;Genes;Genetic;Goals;graft vs host disease;Grant;Hematologic Neoplasms;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;high risk;Immune;Immune Tolerance;immunoengineering;Immunology;Immunotherapy;in vivo;Incidence;induced pluripotent stem cell;Industrialization;Industry;Infrastructure;innovation;Intervention;Knock-out;large scale production;Late Effects;leukemia;Malignant neoplasm of gastrointestinal tract;Malignant Neoplasms;manufacture;manufacturing process;Mass Spectrum Analysis;Mediating;medical specialties;member;Methods;Minnesota;Modality;Molecular;Morbidity - disease rate;mortality;Myelosuppression;Natural Killer Cells;Neurotoxicity Syndromes;novel;Opportunistic Infections;Paper;Patients;pharmacologic;Phase;Physicians;prevent;Process;programs;Proliferating;Proteins;Public Health Informatics;Publishing;Recording of previous events;Regulatory T-Lymphocyte;Relapse;relapse risk;Research;Research Personnel;Resource Sharing;response;Rest;Risk;risk minimization;Rural;Schools;Scientist;side effect;Signal Transduction;Site;Specificity;Speed;stem;stem cells;Strategic Planning;success;T-Lymphocyte;Technology;Testing;Therapeutic;tissue injury;Toxic effect;translational medicine;Translational Research;translational scientist;transplantation therapy;tumor;Tumor Tissue;Tumor-Infiltrating Lymphocytes;Twin Cities;United States National Institutes of Health;Universities;University of Minnesota Cancer Center

PROJECT_TITLE: Transplant and Cellular Therapy


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Hematology;Prevention;Rural Health;Social Determinants of Health

PI_NAMEs: POYNTER, JENNY N. (contact)

PROJECT_TERMS: Academy;Address;Advanced Malignant Neoplasm;Advocacy;Advocate;anti-cancer research;Appointment;Area;Breast;Breast Cancer Detection;Cancer Burden;Cancer Center;Cancer Center Support Grant;cancer clinical trial;Cancer Control;cancer education;Catchment Area;Caucasians;Clinical;Clinical Trials;Clinical Trials Network;Colorectal;Communities;community based participatory research;community center;community engagement;community organizations;Community Outreach;community partners;community partnership;Consultations;Data;Disparity;dissemination strategy;Doctor of Philosophy;Enrollment;Epidemiologist;Equity;Event;Evidence based intervention;experience;Federally Qualified Health Center;Fostering;Funding;Future;Goals;Grant;Health;health care service organization;health equity;Health Personnel;Healthcare;human old age (65+);Immigrant;implementation science;improved;Incidence;Individual;Infrastructure;Institution;Intervention;Knowledge;Leadership;leukemia;Lung;Lymphoma;Malignant Neoplasms;Medicine;Melanoma;member;Mentors;Minnesota;Minority Groups;Mission;Modeling;modifiable risk;Monitor;mortality;Needs Assessment;Not Hispanic or Latino;Oral;outreach;patient navigation;Patients;Population;population health;Population Heterogeneity;Population Sciences;Practice based research;programs;protective factors;Research;Research Personnel;Research Priority;Risk Factors;Rural;Rural Population;Screening for cancer;screening program;Services;Skin;sociodemographics;Specialist;success;Television;Tobacco;Training;Underrepresented Populations;Universities;Woman;Work

PROJECT_TITLE: Community Outreach and Engagement


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention

PROJECT_TERMS: Acceleration;Address;Aging;anti-cancer research;Applications Grants;Area;Award;Budgets;Cancer Burden;cancer care;Cancer Center;Cancer Center Support Grant;cancer prevention;cancer therapy;care providers;Catchment Area;Cell Line;Clinical Research;Collaborations;Communities;community organizations;design;Development;Disease;Diverse Workforce;Environmental Exposure;Equity;Etiology;experience;Faculty;Faculty Recruitment;faculty support;falls;Fostering;Funding;Goals;Grant;Growth;Guidelines;Health Disparities Research;health disparity;health equity;improved outcome;innovation;Investments;Laboratory Research;Leadership;lens;Malignant Neoplasms;member;Minnesota;Mission;multidisciplinary;next generation;Patients;Pilot Projects;Population Research;potential biomarker;Prevention;programs;proteogenomics;Publications;recruit;Research;research faculty;Research Personnel;Research Project Grants;Research Technics;Resource Sharing;Resources;screening;senescence;Strategic Planning;survivorship;Teacher Professional Development;technology/technique;Time;translational potential;Translational Research;Universities;Update;Wages

PROJECT_TITLE: Developmental Funds


NIH_SPENDING_CATS: Biotechnology;Cancer

PI_NAMEs: LANGE, CAROL A (contact)

PROJECT_TERMS: Advisory Committees;Analytical Biochemistry;Antibodies;Area;Award;Basic Science;Biological Markers;Biometry;Cancer Center;Cancer Center Support Grant;cancer genomics;Cell Therapy;Cells;Chemicals;Clinical Research;Collaborations;Communication;Communities;Comparative Pathology;cost;cost effective;cost effectiveness;Data;Direct Costs;Engineering;Ensure;Environmental Exposure;Faculty;feeding;Flow Cytometry;Funding;Funding Agency;Genome engineering;Genomics;Goals;Grant;Health;Human;Immunotherapeutic agent;improved;Informatics;Infrastructure;innovation;Institution;Investments;Laboratory Animals;Leadership;Malignant Neoplasms;Marketing;Mediation;member;Minnesota;Monitor;mouse genetics;National Cancer Institute;neoantigens;Newsletter;next generation;operation;Outcome;outreach;Positioning Attribute;preclinical development;Procedures;Productivity;programs;Proteins;proteogenomics;Proteomics;quality assurance;Recombinant Antibody;Reporting;Reproducibility;Research;research and development;Research Personnel;Research Project Grants;Resource Sharing;Resources;satisfaction;Science;Services;social media;Structure;success;Surveys;Technology;tobacco products;Translational Research;translational therapeutics;transplantation therapy;Twin Cities;Universities;University of Minnesota Cancer Center;Vision;web site;Work

PROJECT_TITLE: Shared Resource Management


PROJECT_TERMS: Acceleration;anti-cancer research;Area;Basic Science;Cancer Burden;cancer care;Cancer Center;Cancer Center Support Grant;cancer research center director;cancer therapy;care providers;Catchment Area;Clinical;clinical care;Clinical Research;Clinical Trials;Collaborations;Communities;community engagement;community organizations;Community Outreach;community partners;Discipline;Disease;Ecosystem;education research;Elements;Ensure;Equipment and supply inventories;equity, diversity, and inclusion;Evaluation;Faculty;Feedback;Fostering;Funding;Future;Goals;Home;improved;improved outcome;Industry Collaboration;innovation;Institution;Interview;Laboratory Research;Leadership;Malignant Neoplasms;Measures;meetings;member;Minnesota;Minority Groups;Mission;multidisciplinary;NCI Center for Cancer Research;next generation;Outcome;Performance;Population;Population Research;Positioning Attribute;Prevention;Process;Program Evaluation;programs;recruit;Research;Research Activity;Resource Allocation;Resource Sharing;Resources;Role;Schools;Strategic Planning;Structure;Translational Research;Underrepresented Populations;Universities;Vision;Women's Group

PROJECT_TITLE: Leadership, Planning and Evaluation


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Patient Safety

PI_NAMEs: GELLER, MELISSA ANN (contact)

PROJECT_TERMS: Address;anti-cancer research;bench to bedside;Budgets;Cancer Center;Cancer Center Support Grant;cancer clinical trial;Catchment Area;Cell Therapy;Clinical;Clinical Cancer Center;Clinical Data;clinical encounter;Clinical Investigator;Clinical Management;Clinical Protocols;Clinical Research;clinical trial implementation;Clinical Trials;Clinical Trials Network;Communities;community engagement;Community Outreach;community partnership;Complex;Conduct Clinical Trials;Consent;cost effective;cultural competence;Data;data integrity;data management;data tools;Dedications;Development;Developmental Therapeutics Program;Disease;early phase clinical trial;Electronics;Ensure;Equity;equity, diversity, and inclusion;Faculty;Fostering;Funding;Growth;Health;Hematologic Neoplasms;Hematology;Immunotherapy;implementation tool;improved;Individual;Infrastructure;innovation;interest;Intervention;Investigational New Drug Application;investigator-initiated trial;Lead;Leadership;Life Cycle Stages;life span;Location;Malignant Neoplasms;Medical;Medicine;member;Mentors;Mentorship;Minnesota;Mission;Monitor;National Clinical Trials Network;novel;Nurses;Nursing Research;Office Management;operation;pandemic disease;Paper;Participant;Patient Recruitments;Patients;Performance;Phase;Physicians;Population Heterogeneity;Positioning Attribute;Procedures;Process;professor;programs;protocol development;Protocols documentation;quality assurance;recruit;Research;Research Personnel;Resources;Role;Services;Site;Solid Neoplasm;Source;Specialist;Standardization;Strategic Planning;Structure;System;telehealth;Therapeutic Clinical Trial;Therapeutic Intervention;Therapeutic Studies;Time;timeline;tool;Training and Education;Translations;transplantation therapy;trial enrollment;Underrepresented Populations;Universities;Woman;Work

PROJECT_TITLE: Clinical Protocol and Data Management


PI_NAMEs: WEIGEL, BRENDA J. (contact)

PROJECT_TERMS: Address;Authorization documentation;Blood;Bone Marrow Transplantation;Cancer Center;Cancer Center Support Grant;Cancer Control;cancer prevention;Caring;Clinical Management;Clinical Research;Clinical Trials;Data;Discipline;Disease;Electronics;Ensure;Epidemiology;Faculty;Feasibility Studies;Feedback;Funding;Goals;graduate student;Grant;Hematology;human subject;Industry;Institutional Review Boards;Knowledge;Leadership;Letters;Malignant Neoplasms;medical schools;meetings;member;Minnesota;Monitor;Office Management;Patients;Pediatrics;Pharmacology;Physicians;Process;Protocols documentation;Provider;Published Comment;Research;Research Personnel;Resources;Review Committee;Risk;Safety;Site;Solid Neoplasm;sound;System;Time;timeline;treatment planning;trial enrollment;Universities

PROJECT_TITLE: Protocol Review and Monitoring System


PI_NAMEs: VILLALTA, PETER WILLIAM (contact)

PROJECT_TERMS: adduct;Analytical Biochemistry;Aromatic Polycyclic Hydrocarbons;Bioinformatics;bioinformatics tool;Biological Assay;Biological Markers;biomarker validation;Blood;Cancer Center;Cancer Center Support Grant;carcinogenesis;Carcinogens;Chemical Exposure;Chemicals;Chemoprevention;Chromatography;Complex;Computer software;Cotinine;Coupled;Data;Data Analyses;Data Set;Dedications;DNA;DNA Adducts;DNA-protein crosslink;Educational process of instructing;experience;Facility Accesses;frontier;Funding;Gas Chromatography;Goals;graduate student;Hemoglobin;Hour;Human;instrument;instrumentation;Laboratories;Liquid Chromatography;Maintenance;mass spectrometer;Mass Spectrum Analysis;Measures;member;metabolomics;method development;Methods;Nicotine;Nitrosamines;Nucleic Acids;Nucleosides;Oligonucleotides;operation;Peptides;Plasma;Postdoctoral Fellow;Prevention program;Process;Proteins;Proteome;Proteomics;Research Personnel;Resource Sharing;Resources;Running;Saliva;Services;small molecule;Software Tools;Speed;Supervision;Tobacco;tobacco products;Training;Urine;Vendor;volatile organic compound;Work

PROJECT_TITLE: Analytical Biochemistry Shared Resource


PI_NAMEs: LE, CHAP T. (contact)

PROJECT_TERMS: Applications Grants;Area;Basic Science;Bioinformatics;Bioinformatics Shared Resource;Biometry;Biostatistics Shared Resource;Cancer Center;Cancer Center Support Grant;Cell Therapy;Clinical Protocols;Clinical Sciences;Clinical Trials;Collaborations;Consultations;Continuing Education;Data;Data Analyses;data management;design;Education;Ensure;Experimental Designs;Faculty;Funding;graduate student;Individual;Leadership;Malignant Neoplasms;Medical Oncology;meetings;member;Mentors;Methods;mid-career faculty;Mission;Monitor;next generation sequencing;Operative Surgical Procedures;Play;Population Sciences;Preparation;professor;programs;Protocols documentation;quality assurance;Reporting;Reproducibility;Research;Research Personnel;Research Project Grants;Resource Sharing;Review Committee;Safety;senior faculty;Services;Time;transplantation therapy

PROJECT_TITLE: Biostatistics Shared Resource


PI_NAMEs: BECKMAN, KENNETH B (contact)

PROJECT_TERMS: Address;Affect;Awareness;Biological Assay;Cancer Center;Cancer Center Support Grant;cancer genomics;Cell Line;Chromosome Mapping;Clinical;Complex;Consultations;cost;Data;Depreciation;Detection;Direct Costs;Doctor of Philosophy;Education;Ensure;epigenomics;Equipment;experience;feasibility testing;Fees;Fluorescent in Situ Hybridization;Future;Gene Expression;Gene Fusion;Generations;Genetic;genomic tools;Genomics;Genomics Shared Resource;high throughput screening;instrument;instrumentation;Investigation;Link;Liquid substance;Maintenance;Malignant Neoplasms;member;Methods;Minnesota;Mission;next generation sequencing;Optics;Organization and Administration;Play;Price;programs;Quality Control;Reagent;Research;Research Activity;Research Design;Research Personnel;Research Project Grants;Role;Sampling;service organization;Services;single cell analysis;single cell genomics;single cell sequencing;symposium;targeted sequencing;Techniques;Technology;Testing;Time;Tissues;Universities

PROJECT_TITLE: Cancer Genomics Shared Resource


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Data Science;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Precision Medicine

PI_NAMEs: WANG, JINHUA  (contact)

PROJECT_TERMS: anti-cancer research;Area;Artificial Intelligence;Big Data;Bioinformatics;biomedical informatics;Biostatistics Shared Resource;Cancer Center;Cancer Center Support Grant;Cancer Patient;cancer therapy;Cells;Clinical;Clinical Data;clinical development;Clinical Informatics;Clinical Informatics Shared Resource;Clinical Research;Clinical Sciences;clinical trial recruitment;Clinical Trials;Collaborations;Communities;Computer Models;Computer software;Data;Data Analyses;Data Analytics;data integration;data repository;Data Science;Data Set;Data Storage and Retrieval;Databases;Decision Modeling;deep learning;design;Development;digital twin;DNA;Ensure;Environment;Faculty;Funding;Generations;Genome;genome resource;genome-wide;genomic data;Genomics;health record;Health Sciences;Home;Image;Individual;Informatics;informatics shared resource;Infrastructure;interest;Lead;Link;Machine Learning;Malignant Neoplasms;Medical Informatics;member;Methods;Minnesota;Mission;Modeling;Modernization;Molecular;Multiomic Data;multiple omics;Natural Language Processing;NCI Center for Cancer Research;Oncology;open source;Patient Care;precision oncology;Predictive Cancer Model;Privatization;Process;programs;Proteomics;Public Health Informatics;recruit;Reporting;repository;Research;research and development;research faculty;Research Personnel;Resource Sharing;Resources;Retrieval;Schools;Scientist;Secure;senior faculty;Services;success;System;Technology;Training and Education;transcriptomics;translational cancer research;Translational Research;translational therapeutics;Universities

PROJECT_TITLE: Cancer Informatics Shared Resource


PI_NAMEs: SEELIG, DAVIS MARTIN (contact)

PROJECT_TERMS: animal tissue;Animals;Applications Grants;Autopsy;Board Certification;bone;Cancer Center;Cancer Center Support Grant;cancer genomics;Clinical Pathology;Collaborations;college;comparative;Comparative Pathology;cost effective;Data;Data Analyses;design;digital imaging;Doctor of Philosophy;Ensure;experience;experimental study;Feedback;Freezing;Generations;Genomics Shared Resource;Grant;Histologic;Histology;Histopathology;imaging facilities;Immunohistochemistry;Individual;interest;Laboratories;Laboratory Research;Manuscripts;meetings;member;Minnesota;Mission;Modeling;NCI Center for Cancer Research;neuropathology;novel;operation;Pathologist;Pathology;Performance;Phase;post-pandemic;Postdoctoral Fellow;Preparation;Process;protocol development;Protocols documentation;Publications;Reporting;Research;Research Design;Research Personnel;Research Project Grants;Resolution;Resource Sharing;Resources;response;sample collection;Services;Specimen;Stains;System;Tissue Banks;Tissues;Training;Universities;Veterinary Anatomy;Veterinary Medicine;Veterinary Pathology

PROJECT_TITLE: Comparative Pathology Shared Resource


PI_NAMEs: PENNELL, CHRISTOPHER A (contact)

PROJECT_TERMS: Acceleration;Cancer Biology;Cancer Center;Cancer Center Support Grant;Cells;Clinical;Communities;cost;cost effective;data acquisition;Data Analyses;design;Ensure;Equipment;experience;experimental study;Flow Cytometry;Flow Cytometry Shared Resource;Hour;Human Resources;Immunology;Industry;innovation;instrument;Knowledge;Laboratories;member;Minnesota;Mission;Names;NCI Center for Cancer Research;new technology;operation;Persons;Phenotype;programs;Reagent;Research;Research Personnel;Resources;Role;Services;Strategic Planning;Testing;Training;Universities

PROJECT_TITLE: Flow Cytometry Shared Resource


NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PI_NAMEs: MORIARITY, BRANDEN S (contact)

PROJECT_TERMS: Acceleration;Adoptive Cell Transfers;Biological Models;Cancer cell line;Cancer Center;Cancer Center Support Grant;Cell Line;Cell model;Cell Therapy;Cells;Client;Clinical;conditional knockout;Consumption;cost effective;CRISPR/Cas technology;design;Engineering;Essential Genes;experience;Experimental Designs;experimental study;Gene Modified;Gene Targeting;Generations;Genes;Genetic;Genetic Diseases;Genetic Services;genome editing;Genome engineering;Goals;Human;Human Cell Line;human induced pluripotent stem cells;Human Resources;Immune;Immunology;Individual;Knock-in;Knock-out;Laboratories;Malignant Neoplasms;Mediating;member;Modification;mouse genetics;Mouse Strains;Mutant Strains Mice;Mutation;novel therapeutics;Nucleotides;Palpable;Productivity;programs;Publications;Reagent;Research;Research Peer Review;Research Personnel;research study;Resource Sharing;Services;Source;stem cell biology;stem cells;synergism;System;Techniques;Testing;Time;transcription activator-like effector nucleases;transplantation therapy;Work

PROJECT_TITLE: Genome Engineering Shared Resource


NIH_SPENDING_CATS: Cancer;Genetics;Rare Diseases

PI_NAMEs: HALLSTROM, TIMOTHY C. (contact)

PROJECT_TERMS: Acute Myelocytic Leukemia;anti-cancer research;B lymphoid malignancy;Breeding;Cancer Biology;Cancer Center;Cancer Center Support Grant;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Colorectal Cancer;Communities;Complex;Consultations;Core Facility;cost effective;COVID-19 outbreak;Cryopreservation;Dependovirus;Derivation procedure;DNA;Doctor of Philosophy;Embryo;embryo cell;embryo cryopreservation;experience;Freezing;Funding;Gene Modified;Genes;Genetic;Genetic Research;Genetic Screening;Genome engineering;Glioma;Immune Evasion;Immunity;Immunology;improved;in vivo;Knockout Mice;Laboratories;Laboratory Research;Leadership;Maintenance;Malignant Breast Neoplasm;Malignant Neoplasms;member;Memorial Sloan-Kettering Cancer Center;Methods;Modeling;mouse genetics;Mouse Strains;Mus;Neoplasm Metastasis;operation;Osteosarcoma;Peripheral Nerve Sheath Neoplasm;Policies;Price;Procedures;programs;Protocols documentation;Provider;recruit;Research Personnel;Resource Sharing;Retinoblastoma Protein;Role;Schwann Cells;Screening for cancer;Services;sperm cell;sperm cryopreservation;System;T-Cell Development;T-Cell Leukemia;Technology;tool;trait;Transgenic Mice;Transgenic Organisms;tumor;Tumor Immunity;tumor initiation;Universities;Work

PROJECT_TITLE: Mouse Genetics Laboratory Shared Resource


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Immunotherapy;Microbiome;Networking and Information Technology R&D (NITRD)

PI_NAMEs: GRIFFIN, TIMOTHY J. (contact)

PROJECT_TERMS: Amino Acid Sequence;Analytical Biochemistry;anti-cancer research;Antibodies;Applications Grants;Base Sequence;Basic Science;Bioinformatics;bioinformatics tool;Biological Markers;Cancer Center Support Grant;cancer genomics;cancer type;carcinogenesis;Clinical;Clinical Research;Collaborations;Coupled;Data;data integration;Development;Diagnosis;diagnostic biomarker;DNA;DNA Sequence;Doctor of Philosophy;Environment;Experimental Designs;flexibility;Follow-Up Studies;Funding;Galaxy;Generations;Genetic;genomic locus;Genomics Shared Resource;host-microbe interactions;Immune response;Immune system;immunogenicity;Immunooncology;Immunotherapeutic agent;improved;Informatics;Malignant Neoplasms;Mass Spectrum Analysis;member;metabolomics;Metagenomics;metaproteomics;Microbe;microbial community;microbiome;microbiome research;Minnesota;Molecular;Multiomic Data;multiple omics;neoantigens;next generation;next generation sequencing;novel;Peptides;predictive tools;programs;Proteins;proteogenomics;Proteome;Proteomics;Records;Research;Research Design;Research Personnel;research study;Resolution;Resource Sharing;Resources;RNA Sequences;Sampling;Services;Software Validation;success;Supercomputing;Technology;tool;transcriptome sequencing;Translational Research;translational study;Universities;Variant;Work

PROJECT_TITLE: Proteogenomics Shared Resource


NIH_SPENDING_CATS: Biotechnology;Cancer;Immunotherapy;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Nonembryonic - Human

PI_NAMEs: FELICES, MARTIN  (contact)

PROJECT_TERMS: Aftercare;Allogenic;Basic Science;biobank;Biological;Biological Assay;Biological Products;Biological Response Modifier Therapy;Biological Specimen Banks;Blood;Blood specimen;Cancer Center;Cancer Center Support Grant;Cancer Patient;Cell Therapy;cGMP production;Characteristics;Clinic;Clinical;Clinical Informatics;Clinical Informatics Shared Resource;Clinical Management;Clinical Research;Clinical Trials;Collaborations;Computer software;Cyclic GMP;Development;Doctor of Philosophy;Goals;Hematopoietic Stem Cell Transplantation;Human Resources;immune function;Immunologic Adjuvants;Immunologic Monitoring;Immunology;Immunotherapy;induced pluripotent stem cell;Information Technology;Infusion procedures;Laboratories;Laboratory Study;Leadership;Malignant Neoplasms;manufacture;Marrow;Medicine;member;mid-career faculty;Molecular;Monitor;Monitoring Clinical Trials;Natural Killer Cells;novel;novel therapeutics;Outcome;participant enrollment;Patient Care;Patient Participation;Pediatrics;Persons;Physician Executives;pre-clinical;pre-clinical research;Process;Production;professor;programs;Reagent;Regulatory T-Lymphocyte;repository;Research;Research Personnel;research study;Research Support;Resource Sharing;Resources;Running;Sampling;Services;Standardization;systems research;Techniques;Testing;translational cancer research;Translational Research;translational therapeutics;Translations;transplantation therapy;Vaccines;Validation;Work

PROJECT_TITLE: Translational Therapy Shared Resource


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Breastfeeding, Lactation and Breast Milk;Childhood Obesity;Maternal Health;Neurosciences;Nutrition;Obesity;Pediatric;Women's Health Research

ORG_CITY: CHAMPAIGN

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

ORG_STATE: IL

PHR: Project Narrative: During lactation food intake is increased to accommodate the energetically demanding process of nursing. These adaptive changes are critical for the long-term health of the mother and child, as excessive or insufficient energy intake of the mother during lactation increases the subsequent risk of both the mother and child developing metabolic and psychiatric disorders later in life. This proposal will determine the neural circuitry and molecular mechanism(s) mediating increased food intake during lactation, providing novel targets for improving the metabolic and reproductive health of women.

PI_NAMEs: SWEENEY, PATRICK  (contact)

PROGRAM_OFFICER_NAME: ROSS, SHARON A

PROJECT_TERMS: Animals;anorexic;Behavioral Assay;Biological Assay;Body Weight;Cell Nucleus;Child;Consumption;Devices;Eating;Energy Intake;Energy Metabolism;Fatty acid glycerol esters;feeding;Feeding behaviors;Female;Fiber;Fluorescent in Situ Hybridization;Food;Food deprivation (experimental);Food Energy;Foundations;Future;Genetic;Health;health of the mother;hedonic;hindbrain;Home;Homeostasis;Human;Hunger;Hyperphagia;Hypothalamic structure;imaging approach;Immunohistochemistry;improved;in vivo;in vivo imaging;Lactation;lactation period;Life;Mammals;Maps;Mediating;Mental disorders;Metabolic;Metabolic Diseases;microendoscopy;Midbrain structure;Molecular;Mothers;Motivation;Mus;neonatal mice;neural circuit;Neuroanatomy;Neurons;neuropsychiatry;novel;Nursing Process;optogenetics;Pathway interactions;Photometry;Population;Pregnancy;Reproduction;reproductive;response;reward circuitry;Rewards;Risk;Rodent;Role;Satiation;Satiety Response;sex;Signal Transduction;sugar;Therapeutic;transcriptomics;Transgenic Mice;Viscera;women's reproductive health;Work

PROJECT_TITLE: Neural circuitry mediating lactation-induced hyperphagia

STUDY_SECTION: POMD

STUDY_SECTION_NAME: Pathophysiology of Obesity and Metabolic Disease Study Section[POMD]


NIH_SPENDING_CATS: Cancer

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: NARRATIVE The landscape of biomedical research in the United States is changing, as are the composition and activities of the biomedical research workforce. With this evolution comes an increasing need to encourage talented young people to explore this changing landscape and pursue careers that will contribute to a better understanding of the factors that promote the diseases under investigation, the development of methodologies to predict and/or prevent disease progression, and the discovery of therapies that will help cure patients. The Summer Research Experience in Cancer (SuRE-C) Program at the University of Virginia will continue to address this need by providing undergraduate and medical student trainees with an immersive research experience within a rich cancer research community that boasts strong and diverse basic science, an NCI-designated Comprehensive Cancer Center, and opportunities for exposure to the practice and challenges of providing clinical care to cancer patients.

PI_NAMEs: CROSS, JANET V;ZONG, HUI  (contact)

PROGRAM_OFFICER_NAME: RADAEV, SERGEY

PROJECT_TERMS: Address;anti-cancer research;Basic Science;Behavioral Research;Biomedical Research;cancer care;Cancer Patient;cancer therapy;care providers;career;clinical care;Clinical Research;Collaborations;Communication;Communities;Complement;Comprehensive Cancer Center;Dedications;Development;Diagnosis;Discipline;Disease;Disease Progression;Education;Educational Grants;Enrollment;Ensure;Evolution;experience;Exposure to;Faculty;Fostering;Foundations;Funding;Future;Goals;innovation;interest;Investigation;Malignant Neoplasms;Medical Students;member;Mentors;Methodology;Mission;Molecular;next generation;Patients;Persons;Positioning Attribute;Postbaccalaureate;prevent;Prevention;programs;Research;Research Personnel;Research Project Grants;Scientist;skill acquisition;Students;success;summer research;synergism;Talents;Training;Translational Research;undergraduate student;United States;Universities;Virginia

PROJECT_TITLE: Summer Research Experience in Cancer(SuRE-C)

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics

ORG_CITY: BAR HARBOR

ORG_NAME: JACKSON LABORATORY

ORG_STATE: ME

PHR: PROJECT NARRATIVE Cancer remains a largely incurable disease and the mouse remains a key model for human cancer. Thus, this short course proposes to accelerate the understanding of the next generation of cancer investigators in cutting edge modeling of human cancer including experimental cancer models, modern technology to assess mechanisms and outcomes, testing of emerging cancer therapies, and the contributions of the tumor and host genetics, as well as tumor microenvironment including its interplay with the immune system. The course will promote networking and multi-disciplinary collaboration, and will inform and train junior investigators in state-of- the-art approaches for conducting rigorous studies that utilize and leverage models of human cancer.

PI_NAMEs: BERWIN, BRENT L;PALUCKA, ANNA KAROLINA  (contact)

PROGRAM_OFFICER_NAME: ZAHIR, NASTARAN

PROJECT_TERMS: Acceleration;Active Learning;Address;analytical tool;anti-cancer;anti-cancer research;Area;Basic Science;Bioinformatics;Biological Models;biomedical scientist;Cancer Biology;Cancer Center;cancer genomics;Cancer Model;cancer therapy;career;career development;career networking;Cell Line;Cells;Clinical;Clinical Research;Complex;design;Development;disadvantaged background;Disease;Education;Educational Curriculum;Educational process of instructing;Educational workshop;empowerment;Environment;Epigenetic Process;Evaluation;experience;Experimental Designs;Experimental Models;Faculty;flexibility;Funding;Future;Generations;Genetic;genetic approach;Genetic Databases;Genomics;Goals;graduate student;Grant;health care disparity;Human;Human Genetics;human model;Hybrids;Immersion;Immune;Immune response;Immune system;improved;Individual;Interdisciplinary Study;Knowledge;Laboratories;Learning;lecturer;lectures;Link;Malignant Neoplasms;Mammalian Genetics;Medical;Medical Ethics;Medical Oncologist;meetings;Methodology;Minority;Modeling;Modernization;Molecular;Molecular Genetics;mouse genetics;mouse model;multidisciplinary;Mus;Mutation;neoplastic cell;next generation;Oncology;Ontology;Organoids;Outcome;Participant;Pathogenesis;Pathway interactions;patient derived xenograft model;Patient Recruitments;Patients;Persons;Postdoctoral Fellow;posters;programs;recruit;Recruitment Activity;Research;Research Personnel;research study;Resources;Sampling;Scholarship;Scientist;skills;Study models;Surveys;synergism;Techniques;Technology;Testing;The Jackson Laboratory;Therapeutic;therapy resistant;tool;Training;Training and Education;Training Programs;Travel;tumor;tumor immunology;tumor microenvironment;Update;virtual;Vision

PROJECT_TITLE: Short Course on Experimental Models of Human Cancer


NIH_SPENDING_CATS: Clinical Research;Emergency Care;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: WASHINGTON

ORG_NAME: CHILDREN'S RESEARCH INSTITUTE

ORG_STATE: DC

PHR: Project Narrative The proposed research is relevant to public health because health disparities have been identified across the spectrum of care and conditions for the hospitalized child; although responses to address disparities in pediatric care need to be multi-factorial, key strategies include fostering a more diverse pediatric workforce and developing expertise in health equity research. The project is relevant to NICHD’S R25 mission because Health Equity Academic Research in Pediatric Hospital Medicine (HEAR-PHM) is a research education program that supports creative education activities to focus on research skill development in an area of critical need, specifically health equity research focused on the acute care continuum for children. As a young pediatric subspeciality with care expertise across a broad spectrum of hospital care, PHM has the unique opportunity to promote a diverse academic workforce and develop research leaders to improve health equity in the care of hospitalized children.

PI_NAMEs: DIXON, GABRINA L.;PARIKH, KAVITA  (contact)

PROGRAM_OFFICER_NAME: JENKINS, TAMMARA L

PROJECT_TERMS: Academy;Accreditation;acute care;Address;Admission activity;American;Antibiotics;Appendicitis;Area;Attention;Awareness;Caring;Censuses;Child;Child health care;Child health equity;Childhood;Chronic;Clinical;clinical practice;Communities;Complex;Continuity of Patient Care;Country;Creativeness;Critical Care;Data;Dedications;Development;Diagnostic Imaging;Disparity;Education;Education Projects;education research;Educational Activities;Educational Curriculum;Emergency Medicine;Ensure;Equity;ethnic health disparity;ethnic minority;Ethnic Origin;Event;experience;Face;Faculty;Fostering;Gender Identity;gender preference;Geography;graduate medical education;hands on research;Health;health care delivery;health care disparity;health care quality;health care settings;health disparity;health equity;Health equity research;health inequalities;Health system;Healthcare;hospital care;Hospital safety;Hospital Societies;Hospitalists;Hospitalization;Hospitalized Child;Hospitals;Hour;improved;Individual;innovation;Inpatients;Intensive Care Units;Knowledge;Lead;Leadership;lectures;Medical;Medical Education;medical specialties;Medicine;minority children;Mission;Modeling;National Institute of Child Health and Human Development;Not Hispanic or Latino;Outcome;Pain management;Patient Care;Pattern;pediatric emergency;Pediatric Hospitals;Pediatric Research;pediatrician;Pediatrics;Population;Positioning Attribute;pressure;programs;Public Health;Race;racial disparity;racial minority;readmission rates;Recording of previous events;recruit;Reporting;repository;Research;Research Personnel;Research Project Grants;Research Training;Resources;Respiratory Tract Infections;response;Scholars Program;Sepsis;sex;skill acquisition;skills;Socioeconomic Status;System;Trainers Training;Training;Training Support;Translational Research;Underrepresented Populations;United States;Variant

PROJECT_TITLE: Health Equity Academic Research in Pediatric Hospital Medicine (HEAR-PHM) Program

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Pediatrics Study Section[CHHD-A]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Sleep Research

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE  This training program provides state-of-the-art research training for PhD, MD, VMD, and MD/PhD postdoctoral fellows in sleep and circadian research. The program is built on a combination of relevant didactic training with individualized mentored research training. The program includes specific tracks for basic research, clinical/translational research, and development of personalized medicine.

PI_NAMEs: GEHRMAN, PHILIP RICHARD;RAIZEN, DAVID MENASSAH (contact)

PROGRAM_OFFICER_NAME: BAIZER, LAWRENCE

PROJECT_TITLE: Training Program in Chronobiology, Sleep and Sleep Disorders

STUDY_SECTION: NITM

STUDY_SECTION_NAME: NHLBI Institutional Training Mechanism Study Section[NITM (OA)]


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Brain Disorders;Cancer;Chronic Pain;Clinical Research;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Networking and Information Technology R&D (NITRD);Pain Research;Palliative Care;Prevention;Sleep Research;Telehealth

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

PHR: PROGRAM NARRATIVE The proposed R25 program will train frontline cancer clinicians (physicians, advanced practice providers, psychologists, psychiatrists, nurses, and social workers) in the best-practice implementation of technology in cancer supportive care. Training will be carried out through pre-workshop webinars (pre-recorded); skills- based, in-person workshops focused on integration of evidence-based digital health and telehealth solutions with clinical practice, using established care approaches for cancer-related fatigue, insomnia, pain, depression and anxiety, which will also include emphasis on digital equity and working with diverse populations; and post- workshop online video and chat support from program faculty and a learning community of peers. Program content will be updated annually with expert input from our advisory board, and formative and summative evaluations annually and at the end of the program will assess trainee knowledge gained, confidence in technology use, and overall satisfaction with the program.

PI_NAMEs: BREWER, BENJAMIN WILSON (contact);REDD, WILLIAM H

PROJECT_TERMS: Active Learning;Address;Adherence;Anxiety;Area;Award;behavior change;Behavioral;behavioral health;cancer care;Cancer Patient;Caring;Clinic Visits;Clinical;clinical practice;clinically significant;Cognitive;Coping Skills;cost;Data;Devices;digital;digital health;Education Projects;Educational Curriculum;Educational workshop;effectiveness evaluation;Electronic Health Record;eligible participant;Enrollment;Ensure;Epidemiology;Equity;Evaluation;evidence base;experience;Faculty;Fatigue;Feedback;Foundations;Funding;Geography;Goals;health equity;Health Status;Health Technology;Healthcare;Impairment;implementation strategy;improved;innovation;Institute of Medicine (U.S.);interest;Intervention;Knowledge;Learning;learning community;Malignant Neoplasms;Medical;Medicine;Memory;Mental Depression;Mission;mobile application;Modeling;Monitor;Moods;Motivation;multimodality;Needs Assessment;New York City;Nurses;Outcome;Pain;Participant;patient oriented;Patients;peer;Persons;Physical activity;Physicians;Play;Population;Population Heterogeneity;preference;programs;Provider;Psychiatrist;Psychologist;psychosocial;Quality of Care;Race;Reporting;Role;Rural Population;satisfaction;skills;Sleep;sleep quality;Sleeplessness;Social Workers;success;Supportive care;symposium;Technology;technology validation;telehealth;Text Messaging;tool;Training;Training Programs;United States;Update;wearable device;wearable sensor technology;webinar

PROJECT_TITLE: Training clinicians in the integration of technology with cancer supportive care


ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative Infectious diseases are a major cause of morbidity and mortality worldwide, with threats from both old and emerging pathogens. This Training Program proposes to train scientists (graduate students and post-doctoral fellows) to work at the intersection of immunology and microbiology in the study of infectious diseases. Understanding the contribution of both fields to infectious diseases will result in well-trained scientists who will discover cures and prevention strategies to reduce the global burden of infections.

PI_NAMEs: FLYNN, JOANNE L. (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Disease;Immunology;Infection

PROJECT_TITLE: Immunology of Infections Disease Renewal 2023

STUDY_SECTION: AITC

STUDY_SECTION_NAME: Allergy, Immunology, and Transplantation Research Committee[AITC]


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Genetics

ORG_CITY: BATON ROUGE

ORG_NAME: LOUISIANA STATE UNIV AGRICULTURAL CENTER

ORG_STATE: LA

PHR: PROJECT NARRATIVE: The NIH-funded aquatic model stock centers have expressed growing needs for them and their associated research communities to use germplasm repositories in preservation and sharing of genetic resources. Because of a lack of comprehensive repository capabilities, the National Xenopus Resource (NXR), Ambystoma Genetic Resource Center (AGSC), and National Resource for Aplysia (NRA) face many challenges including the risk of losing valuable genetic lines, inefficiency of maintaining living animals, and the struggle to meet increasing demands from their research communities. Based on the success of the ongoing Hub R24 that has developed basic cryopreservation protocols and customized these based on the specific resources and needs of the stock centers, we propose to advance the capabilities at the resource centers from feasibility establishment to operational repositories with high-throughput production and routine quality management programs, and to advance the Aquatic Germplasm and Genetic Resources Center (AGGRC) Hub and NIH Aquatic Biomedical Germplasm Repository Network to facilitate resource management, sharing, and distribution.

PI_NAMEs: KOCH, JACK ;LIU, YUE ;TIERSCH, TERRENCE ROBERT (contact)

PROGRAM_OFFICER_NAME: CONTRERAS, MIGUEL A

PROJECT_TERMS: Achievement;Address;Administrative Supplement;Algae;Ambystoma;Amphibia;Animal Husbandry;Animals;Aplysia;Aplysia species;assisted reproduction;Collaborations;Communities;Cryopreservation;Development;digital media;Educational workshop;egg;Embryo;Ensure;Evaluation;Face;feeding;Fertilization;Foundations;Freezing;fundamental research;Funding;Genetic;genetic resource;Germ;Goals;Grant;Guidelines;improved;Infrastructure;innovation;Larva;Life;meetings;Modeling;Online Systems;operation;Pathway interactions;Positioning Attribute;Preparation;preservation;Production;programs;Protocols documentation;quality assurance;R24;repository;reproductive;Research;Resource Sharing;Resources;Risk;sample collection;Sampling;sharing platform;Site Visit;sperm cell;sperm cryopreservation;sperm viability;Standardization;Strategic Planning;Structure;success;Swimming;Telephone;Training;Translational Research;United States Department of Agriculture;United States National Institutes of Health;Visit;Work;Xenopus

PROJECT_TITLE: Safeguarding Genetic Resources of Aquatic Biomedical Models

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BTC-Y (55)]


NIH_SPENDING_CATS: Biotechnology

ORG_CITY: PULLMAN

ORG_NAME: WASHINGTON STATE UNIVERSITY

ORG_STATE: WA

PHR: C8. Project Narrative The field of protein biotechnology continues to address widely recognized ongoing and emerging public health challenges through medical advances, but contributions extend further to broader public health challenges such as food insecurity, sustainable agriculture, and mitigation of global climate change. To capture this holistic contribution and to train a workforce of skilled and well-trained scientists, our PhD training program focuses on transdisciplinary protein biotechnology that encompasses contributions from fields ranging from engineering, chemistry, chemical engineering, microbiology, molecular biology, and molecular plant sciences. Our trainee-centered, project-based learning approach equips trainees with skills and experiences applicable to a wide range of biotechnology careers in private, public, and academic settings.

PI_NAMEs: LANGE, BERND MARKUS (contact)

PROGRAM_OFFICER_NAME: DAVANI, BEHROUS

PROJECT_TITLE: Training in Biotechnology: Emphasis in Protein Chemistry

STUDY_SECTION_NAME: Training and Workforce Development Study Section - B[TWD-B]