NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Kidney Disease;Physical Activity

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

PHR: PROJECT NARRATIVE We will design and fabricate a portable low-field magnetic resonance sensor to quantitatively assess fluid status. The sensor will measure local fluid distribution in the target in vivo tissue compartment of skeletal muscle. The sensor will be used to assess patients undergoing dialysis treatment and athletes subject to exercise induced fluid loss.

PI_NAMEs: CIMA, MICHAEL J (contact);NIGWEKAR, SAGAR

PROGRAM_OFFICER_NAME: WANG, SHUMIN

PROJECT_TERMS: Affect;Algorithms;associated symptom;Blood Pressure;Body Weight decreased;Cardiovascular system;Cell Nucleus;Clinical;Clinical assessments;clinical decision-making;Clinical Research;Clinical Trials;clinically relevant;Collaborations;Custom;Data;Dehydration;design;Development;Device Designs;Devices;Diagnostic;Dialysis patients;Dialysis procedure;Disease;End stage renal failure;Engineering;Excision;Exclusion;Exercise;experience;Extracellular Fluid;fabrication;Fluid Balance;Fluid overload;Fluid Shifts;Future;Goals;Headache;Health;Heart;Hemodialysis;Hospitalization;Hour;Human;Hypovolemia;Hypovolemics;improved;improved outcome;in vivo;Individual;Institution;Intramuscular;Kidney;Kidney Diseases;Laboratories;Leg;Liquid substance;magnetic field;Magnetic Resonance;Magnetic Resonance Imaging;Maintenance;Measurement;Measures;Methods;mobile sensor;Moderate Exercise;Morbidity - disease rate;mortality;multidisciplinary;Muscle;Muscle Cramp;Nature;Noise;Organ;Outcome;Participant;Patients;Physicians;Physiologic pulse;point of care;Population;portability;Quality of Care;Quality of life;radio frequency;Research;Resources;response;Scientist;sensor;Shapes;Side;signal processing;Signal Transduction;Skeletal Muscle;skeletal muscle differentiation;Soldier;subcutaneous;Subcutaneous Tissue;Surface;Target Populations;Technology;Therapeutic;Time;Tissues;tool;Validation;Water;Work

PROJECT_TITLE: NMR-Based Rapid Fluid Assessment: Device Design and Signal Processing

STUDY_SECTION: ISD

STUDY_SECTION_NAME: Instrumentation and Systems Development Study Section[ISD]


ADMINISTERING_IC: CA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Neurofibromatosis;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Precision Medicine;Prevention;Rare Diseases

ORG_CITY: INDIANAPOLIS

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PEDIATRICS

ORG_FIPS: US

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: PROJECT NARRATIVE Neurofibromatosis type 1-associated atypical neurofibromas (ANF) are precursor lesions for a highly aggressive form of soft tissue sarcoma that is uniformly fatal in persons with unresectable disease. Here we propose to develop a robust preclinical-clinical pipeline to accelerate the translation of novel single agent and combination therapies to effectively treat ANF and prevent malignant transformation, while identifying robust biomarkers associated with treatment response. Our integrated and multidisciplinary approach will address the challenges of cancer prevention in an orphan cancer predisposition syndrome and uniquely vulnerable patient population for which no effective medical therapies currently exist.

PI_NAMEs: CLAPP, DAVID W (contact)

PROGRAM_OFFICER_NAME: SONG, MIN-KYUNG H

PROJECT_TERMS: Acceleration;Address;Benign;Biological Markers;Biology;biomarker identification;cancer predisposition;cancer prevention;CDK4 gene;CDKN2A gene;Cells;Cessation of life;Childhood;Clinic;Clinical;Clinical Investigator;Clinical Research;Clinical Trials;Clonal Evolution;Collaborations;Combined Modality Therapy;Coupled;Data;Development;Disease;Epigenetic Process;Evolution;Excision;Extramural Activities;Genetic Transcription;Genomics;Goals;Histology;Human;Individual;Infrastructure;inhibitor;innovation;interdisciplinary approach;Lead;Lesion;liquid biopsy;Location;Malignant - descriptor;Malignant Neoplasms;MAP2K1 gene;Medical;MEK inhibition;MEKs;Molecular;molecular marker;Monitor;Morbidity - disease rate;mouse model;multiple omics;Mus;Natural History;neurofibroma;Neurofibromatosis 1;Neurofibrosarcoma;new combination therapies;novel;novel therapeutic intervention;Operative Surgical Procedures;Orphan;participant enrollment;patient population;Patients;Peripheral Nervous System Malignant Neoplasms;Persons;Pharmaceutical Preparations;Phase;Phase 0 Trial;Phosphotransferases;Plexiform Neurofibroma;Population;pre-clinical;Pre-Clinical Model;predicting response;premalignant;premature;prevent;Prevention;Proteomics;Research Personnel;resistance mechanism;response;response biomarker;Risk;Sampling;Series;Signal Induction;small molecule inhibitor;Soft tissue sarcoma;Syndrome;targeted agent;targeted treatment;Testing;Therapeutic;therapeutic development;Therapeutic Intervention;transcriptomics;Translating;translational scientist;Translations;treatment response;tumor;tumor progression;Tumor stage;Tumor Suppressor Proteins;Unresectable;Work

PROJECT_TITLE: Preclinical-clinical trials collaboration to effectively advance new combination therapies for atypical neurofibroma in neurofibromatosis type 1


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Behavioral and Social Science;Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Emerging Infectious Diseases;HIV/AIDS;Health Services;Infectious Diseases;Orphan Drug;Patient Safety;Prevention;Rare Diseases;Telehealth;Tuberculosis

ORG_CITY: NEW YORK

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: Project Narrative Novel antimycobacterial agents, including bedaquiline, and combination antiretroviral therapy containing integrase strand transfer inhibitors, newly available in South Africa, have the potential to revolutionize the treatment of drug-resistant tuberculosis (DR-TB) HIV co-infection, but challenges to medication adherence threaten optimal clinical outcomes and emergent drug resistance. Using a Bayesian, adaptive study design, this project will efficiently evaluate the relative contribution of psychosocial and mHealth adherence interventions, separately and in combination, to improve clinical and biological DR-TB HIV outcomes; understand the mechanism of action of the intervention using a socio-behavioral model and the effect of dual DR-TB and HIV stigma on adherence; and use qualitative methods to delineate patient-centered pathways of care. High-level medication adherence improves mortality, treatment outcomes and reduces transmission for TB and HIV; identifying optimal strategies to enhance adherence may benefit individuals and improve population-level TB and HIV control.

PI_NAMEs: O'DONNELL, MAX  (contact)

PROGRAM_OFFICER_NAME: CRAWFORD, KEITH W

PROJECT_TERMS: Adherence;Adverse effects;Adverse event;Antimycobacterial Agents;antiretroviral therapy;arm;Behavioral;Behavioral Mechanisms;Behavioral Model;Biological;Caring;Cessation of life;Clinical;clinical research site;co-infection;community based care;community transmission;Complement;Complex;Cost Effectiveness Analysis;Data;Dose;Drug Interactions;Drug resistance;Drug resistance in tuberculosis;Effectiveness;effectiveness evaluation;Effectiveness of Interventions;Electronics;Enrollment;Epidemic;Evaluation;evidence base;experience;Goals;Health;Health Status;Health system;high risk;HIV;HIV/AIDS;HIV/TB;implementation science;implementation trial;improved;Individual;inhibitor;innovation;Integrase;Intervention;intervention effect;Interview;Knowledge;Lamivudine;Measurement;Measures;Mediating;Medical;medication compliance;Methods;mHealth;mobile computing;Modality;Modeling;Modification;Monitor;mortality;Motivation;National Institute of Allergy and Infectious Disease;novel;novel therapeutics;Oral;Outcome;Pathway interactions;patient oriented;Patients;person centered;Persons;Pharmaceutical Preparations;pill;Population;Predictive Factor;prevent;primary outcome;prospective;psychosocial;Psychosocial Assessment and Care;Public Health;Qualitative Methods;Randomized;randomized trial;Recommendation;Regimen;Research;Research Design;Research Priority;Resistance;service delivery;skills;social;Social Behavior;social stigma;South Africa;South African;Southern Africa;standard of care;structural determinants;Subgroup;Tenofovir;Time;transmission process;treatment arm;treatment center;Treatment Failure;Treatment outcome;Treatment Protocols;trial design;Tuberculosis;tuberculosis drugs;tuberculosis treatment;Viral Load result;World Health Organization

PROJECT_TITLE: Adaptive evaluation of mHealth and conventional adherence support interventions to optimize outcomes with new treatment regimens for drug-resistant tuberculosis and HIV in South Africa

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


ADMINISTERING_IC: DA

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Neurosciences;Prevention;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: WORCESTER

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

ORG_STATE: MA

PHR: Project Narrative Although smoking tobacco is a leading cause of preventable mortality in adults worldwide, there are few pharmacological smoking cessation aids available and their efficacy is limited. The habenulo-interpeduncular pathway represents an understudied brain circuit that has been found to be involved in nicotine withdrawal symptoms and the aversive motivational properties of nicotine; however, the effects of nicotine on this circuit within the context of reward-related behavior is unknown. Results from this project will elucidate specific neurophysiological mechanisms of nicotine reward/aversion balance within the habenulo-interpeduncular circuit in freely behaving animal models which will contribute to the development of precise treatments for nicotine addiction.

PI_NAMEs: FREELS, TIMOTHY GLENN (contact)

PROGRAM_OFFICER_NAME: FALCON-MORALES, EDGARDO

PROJECT_TERMS: Acetylcholine;addiction liability;Adult;Affect;Affective;Animal Model;Animals;Antismoking;Attenuated;Automobile Driving;Behavior;Behavioral;behavioral study;Biological Assay;Brain;Calcium;calcium indicator;Cessation of life;Cholinergic Receptors;conditioned place preference;Data;Development;Dopamine;Dose;Equilibrium;Fiber;FOS gene;gamma-Aminobutyric Acid;Glutamates;Goals;Habenula;Health;Human;in vivo;insight;interpeduncular nucleus;Measures;Medial;Modeling;Modernization;Motivation;Mus;neural;neuromechanism;Neurons;neurophysiology;Neurosciences;Nicotine;Nicotine Dependence;nicotine exposure;nicotine reward;nicotine seeking behavior;nicotine treatment;nicotine use;Nicotine Withdrawal;Nicotinic Receptors;novel;optogenetics;Pathway interactions;Performance;pharmacologic;Pharmacological Treatment;Pharmacotherapy;Photometry;Play;Population;prevent;preventable death;Procedures;Property;Proxy;Psychological reinforcement;Reporting;Research;response;reward circuitry;Rewards;Rodent Model;Role;sensor;Smoking;smoking cessation;Smoking Cessation Intervention;Smoking treatment;Symptoms;System;Testing;Tobacco;Ventral Tegmental Area;Withdrawal Symptom

PROJECT_TITLE: Involvement of habenulo-interpeduncular circuitry in nicotine reward and aversion


NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Brain Disorders;Immunotherapy;Multiple Sclerosis;Neurodegenerative;Neurosciences;Rheumatoid Arthritis

ORG_CITY: COLUMBUS

ORG_NAME: RESEARCH INST NATIONWIDE CHILDREN'S HOSP

ORG_STATE: OH

PHR: Project Narrative With the increase in auto-immune diseases and emerging concerns of compromised immunity in our aging culture and vulnerable children, understanding T cell signaling, metabolic processes, and the resources required for proper immune response and functioning are extremely relevant to public health. This project explores how metabolism is controlled in T cell immune responses at the level of precise biochemical reaction and molecular interactions, which are amenable to pharmacologic manipulation. This proposal will enable developing novel therapeutic interventions by targeting the metabolic and signaling pathways for T cell-mediated inflammatory and auto-immune diseases, which aligns with the NIAID’s mission to conduct and support basic and applied research to understand better, treat, and ultimately prevent infectious, immunologic, and allergic diseases.

PI_NAMEs: WANG, RUONING  (contact)

PROGRAM_OFFICER_NAME: RICE, JEFFREY S

PROJECT_TERMS: 4-Aminobutyrate aminotransferase;Ablation;Acceleration;Aging;Allergic Disease;Amino Acids;Animal Model;Antigens;Applied Research;Arginine;Autocrine Communication;autoimmune arthritis;Autoimmune Diseases;Autoimmunity;Basic Science;Binding;Biochemical Reaction;Butyrates;Carbon;Catabolism;CD4 Positive T Lymphocytes;Cell Differentiation process;Cell Lineage;cell mediated immune response;Cell Proliferation;Cell Surface Receptors;Cells;Cellular Metabolic Process;Child;Citric Acid Cycle;Clinical;Communicable Diseases;cost;Coupling;cytokine;Deterioration;dietary approach;dietary restriction;Disease;Effector Cell;effector T cell;Environment;Enzymes;Eragrostis;evidence base;Experimental Autoimmune Encephalomyelitis;extracellular;GABA Receptor;gamma-Aminobutyric Acid;Gatekeeping;Gene Expression Profiling;Genes;Genetic;genetic approach;Genetic Models;Glutamates;Glutamine;Homeostasis;Human;IL27RA gene;immune function;Immune response;Immune signaling;Immune System Diseases;Immunity;Immunologic Surveillance;improved;in vivo;Inflammation;Inflammatory;inflammatory modulation;Inflammatory Response;K/BxN model;Ligands;Mediating;Metabolic;Metabolic Pathway;Metabolism;metabolome;Mission;Molecular;mouse model;Multiple Sclerosis;National Institute of Allergy and Infectious Disease;Neurotransmitters;new therapeutic target;novel strategies;novel therapeutic intervention;novel therapeutics;Outcome;Pathogenesis;Pathway Analysis;Pathway interactions;pharmacologic;presynaptic neurons;prevent;Production;programs;Proliferating;Public Health;receptor;Receptor Activation;Receptor Signaling;receptor-mediated signaling;reconstitution;Regulatory T-Lymphocyte;Resources;response;Rheumatoid Arthritis;Role;Sampling;Signal Pathway;Signal Transduction;Signaling Molecule;Specificity;stable isotope;T cell differentiation;T cell response;T-Cell Activation;T-cell inflamed;T-Cell Receptor;T-Lymphocyte;targeted treatment;Testing;Therapeutic;therapy outcome;Tissues;Transaminases;transcriptome

PROJECT_TITLE: Decipher and target GABA metabolism and GABA receptor-mediated signaling in autoimmune diseases


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Orphan Drug;Pediatric;Pediatric Cancer;Radiation Oncology;Rare Diseases

ORG_CITY: SAN ANTONIO

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

ORG_STATE: TX

PHR: Narrative Eighty percent of children with advanced or metastatic sarcoma will die from disease despite aggressive multimodality therapy. In this proposal we aim to define less-toxic and more effective targeted therapeutic approaches in high-risk RAS-driven Embryonal Rhabdomyosarcoma (ERMS) by using patient-derived xenograft models, omics and novel single-mouse testing approaches. Our focus is inhibition of MAPK signaling as potential therapeutic strategy to treat ERMS.

PI_NAMEs: VASEVA, ANGELINA V (contact)

PROGRAM_OFFICER_NAME: AGYIN, JOSEPH KOFI

PROJECT_TERMS: Apoptosis;Biological Assay;Cell Cycle Arrest;Cell Line;chemoradiation;chemotherapeutic agent;chemotherapy;Chemotherapy and/or radiation;Chemotherapy-Oncologic Procedure;Child;Classification;Clinical;Clinical Protocols;Clinical Trials;Clinical Trials Design;Clonal Evolution;Codon Nucleotides;Combination Drug Therapy;Combined Modality Therapy;Data;Diagnosis;Disease;DNA Damage;DNA Repair;DNA sequencing;Dose;Down-Regulation;Embryonal Rhabdomyosarcoma;epigenomics;Event;Experimental Designs;FRAP1 gene;Generations;Genetic;genetic manipulation;Genomics;genotoxicity;Goals;high risk;Immunohistochemistry;improved;improved outcome;in vivo;in vivo Model;inhibitor;innovation;Intervention;knock-down;Lesion;Life;MAP Kinase Gene;MAPK Signaling Pathway Pathway;MEK inhibition;MEKs;Mitogen-Activated Protein Kinase Inhibitor;Modeling;Mus;mutant;Mutation;NF1 gene;novel;Oncogenic;Operative Surgical Procedures;Outcome;Pathway interactions;patient derived xenograft model;Patients;Pharmaceutical Preparations;Pharmacodynamics;PIK3CG gene;Pilot Projects;pre-clinical;preclinical evaluation;Protein Isoforms;Proto-Oncogene Proteins c-akt;protocol development;Protocols documentation;Radiation therapy;Recurrence;Regimen;Regulation;research clinical testing;Resistance;resistance mechanism;response;response biomarker;Rhabdomyosarcoma;Role;Sarcoma;Schedule;screening;Signal Transduction;synergism;targeted treatment;Testing;Therapeutic;Toxic effect;transcriptome sequencing;Translations;treatment response;tumor;tumor xenograft;Vincristine;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Improving Therapeutic Approaches for RAS-driven Embryonal Rhabdomyosarcoma

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 1 Study Section[MCT1]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Prostate Cancer;Racial and Ethnic Minority Health Research;Social Determinants of Health;Urologic Diseases

ORG_DEPT: UROLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE Misinformation about prostate cancer is widely disseminated on popular social networks, and it is unknown to what extent this plays a role in the observed health disparities among Black and Hispanic men. We will study the types of misinformation about prostate cancer being widely disseminated on social media in English and Spanish, its implications for decision-making among Black and Hispanic men with prostate cancer or at-risk for prostate cancer, and whether a brief media literacy intervention or health literacy intervention helps to mitigate the impact of misinformative content. Our proposed work seeks to advance health equity for Black and Hispanic men by identifying and addressing the problem of online misinformation about prostate cancer.

PI_NAMEs: LOEB, STACY  (contact)

PROGRAM_OFFICER_NAME: CHOU, WEN-YING

PROJECT_TERMS: Address;Adult;Aftercare;arm;Biometry;Black race;cancer care;cancer health disparity;Cancer health equity;Classification;Clinical;clinical care;Communities;comparison control;Data;Data Collection;Decision Making;digital;digital health;digital media;efficacy evaluation;efficacy testing;English Language;Epidemiologist;Epidemiology;Equity;Exposure to;Feedback;Focus Groups;Guidelines;Health;health communication;health disparity;health equity;health equity promotion;Health equity research;health inequalities;health literacy;Health Personnel;Hispanic;Information Dissemination;Instagram;Internet;Intervention;intervention delivery;Interview;Knowledge;Language;Lead;literacy;Malignant neoplasm of prostate;Medical;MedlinePlus;men;Misinformation;multidisciplinary;Not Hispanic or Latino;Outcome Study;Participant;Patients;Perception;Play;Prediction of Response to Therapy;predictive modeling;prospective;prostate cancer risk;Prostate Cancer therapy;Public Health;Publishing;Quality of life;Randomized;randomized trial;Randomized, Controlled Trials;Regrets;Reporting;Research;Research Design;Role;Screening for Prostate Cancer;Series;social;social media;Social Network;Source;Spanish;Spanish/English;Surgeon;Surveys;Testing;TikTok;treatment as usual;Trust;trustworthiness;Typology;Urologist;Work

PROJECT_TITLE: Addressing Misinformation to Promote Equity in Prostate Cancer Care


ADMINISTERING_IC: DC

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

ORG_CITY: ROCKVILLE

ORG_NAME: AMERICAN SPEECH-LANGUAGE-HEARING ASSN

ORG_STATE: MD

PHR: The Research Symposium in Communication Sciences and Disorders aims to strengthen the scientific base and increase the research capacity of the discipline, which will lead to improvements in the communication health of millions people with communication or related disorders. The Symposium presentations will advance the scientific dialogue and be broadly disseminated through freely available peer-reviewed publications and transcribed recordings. The associated Travel Award will provide funds to support 130 promising early-career scientists in attending the Research Symposium and engaging in mentored research activities before, during, after the Symposium to increase their recruitment and retention in a research career.

PI_NAMEs: ROGERS, MARGARET A. (contact)

PROGRAM_OFFICER_NAME: STORKEL, HOLLY LYNN

PROJECT_TERMS: American Speech-Language-Hearing Association;Area;Artificial Intelligence;Award;Awareness;base;bilingualism;career;career development;Clinical;clinical trial implementation;Clinical Trials;Cognition;Communication;Communication Disability;Communities;Data;Degree program;Deposition;design;Dimensions;Discipline;Disease;Doctor's Degree;doctoral student;Education;education research;Enrollment;Ensure;Equitable healthcare;Event;experience;Funding;Generations;Genetic;Genetic Transcription;Grant;Health;health communication;Hearing;Hour;improved;innovation;Intervention;Journals;Knowledge;knowledge base;Language;Manuscripts;meetings;Mentors;Methodology;Monitor;next generation;online community;Outcome Measure;Peer Review;Persons;Postdoctoral Fellow;Preparation;Productivity;Publications;Publishing;PubMed;Readiness;recruit;Reporting;Research;Research Activity;Research Personnel;Resources;Science;Scientific Advances and Accomplishments;Scientist;Seminal;Slide;social media;Speech;stem;Students;Surveys;symposium;Time;Travel;web site;Work;Writing


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Genetics;Hematology;Rare Diseases;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: PROJECT NARRATIVE I aim to understand the molecular and cellular mechanisms underlying blood stem cell niche clonal and transcriptional remodeling in myelodysplastic syndrome. I will use lineage tracing, confocal imaging and mosaic mutagenesis to determine and visualize the clonal changes of diseased endothelial and stromal niche cells and evaluate the role of candidate signaling pathways in niche remodeling. These studies will enhance our understanding of the role of the HSPC niche in hematological disorders and will identify new therapeutic targets.

PI_NAMEs: BARON, CHLOE SOPHIE (contact)

PROGRAM_OFFICER_NAME: HATTANGADI, SHILPA MANOHAR

PROJECT_TERMS: adrenomedullin;Adult;Advisory Committees;Affect;Algorithms;angiogenesis;APLN gene;Automobile Driving;Award;Bar Codes;Biochemical;Biological Assay;Blood;Blood Cells;Blood Vessels;Bone Marrow;c-myc Genes;cancer cell;candidate identification;career;career development;Cell Maintenance;Cell Proliferation;cell type;Cells;Clonality;Clone Cells;Color;computational basis;Computer Analysis;Computing Methodologies;confocal imaging;Confocal Microscopy;CRISPR/Cas technology;Data;Data Set;Disease;disease model;Disease Progression;DNA;Dysmyelopoietic Syndromes;Embryonic Development;Endothelial Cells;Endothelium;Equilibrium;Feedback;Fibroblasts;Flow Cytometry;Gene Expression Profile;Genetic;Genetic Transcription;Goals;Hematological Disease;Hematopoiesis;Hematopoietic;hematopoietic stem cell niche;Hematopoietic stem cells;Heterogeneity;Hormone secretion;Human;improved;in silico;In Vitro;in vivo;in vivo evaluation;Journals;Kidney;Knowledge;Laboratories;Ligands;Marrow;Mediating;Mentorship;Methods;Microscopic;Modeling;Molecular;mosaic;mouse model;multidisciplinary;multiple omics;Mus;Mutagenesis;new therapeutic target;next generation sequencing;novel;Organism;Output;overexpression;Pathogenesis;Pathway interactions;Play;prevent;Prize;progenitor;programs;Proliferating;promoter;Proto-Oncogenes;receptor;Recovery;reflectance confocal microscopy;Reporter;Research;research and development;Research Personnel;response;Role;Science;Signal Pathway;Signal Transduction;single cell mRNA sequencing;stem;stem cell biology;stem cell niche;Stromal Cells;symposium;Technical Expertise;Technology;Testing;tool;transcriptome;transcriptomics;Transgenic Organisms;Transplantation;Vascular Permeabilities;Vascular remodeling;Visualization;Work;Zebrafish

PROJECT_TITLE: Clonal dynamics of the blood stem cell niche


NIH_SPENDING_CATS: Chronic Pain;Drug Abuse (NIDA only);Neurosciences;Opioids;Pain Research;Substance Misuse

ORG_CITY: PHILADELPHIA

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE  Chronic pain is a highly debilitating disorder that adversely impacts the lives of millions of people. Opioid analgesics are commonly prescribed for chronic pain relief because they modulate endogenous opioid signaling in pain-encoding neural circuits; however, these drugs carry substantial abuse and overdose liabilities due to their broad actions on reward- and breathing-related brain regions. For this reason, my proposal will interrogate the critical pain-responsive endogenous opioid circuit of the periaqueductal gray to enhance our understanding of the cell types and neural pathways engaged by opioid compounds and inform future neurocircuit-focused chronic pain therapies that lack the harmful risks of opioid drugs.

PI_NAMEs: KIMMEY, BLAKE  (contact)

PROGRAM_OFFICER_NAME: BABECKI, BETH

PROJECT_TERMS: Absence of pain sensation;Acute;Acute Pain;Agonist;Amygdaloid structure;Analgesics;Animals;antinociception;Attenuated;Automobile Driving;awake;Brain;Brain region;Breathing;Calcium;calcium indicator;Calcium Signaling;cell type;Cells;Central Medial Thalamic Nucleus;chronic pain;chronic pain management;chronic pain patient;chronic pain relief;chronic painful condition;Clinical;Data;Development;Diffuse;Disease;Electric Stimulation;endogenous opioids;Enkephalins;Exhibits;experience;experimental study;Fellowship;Fiber;Future;Genetic;Genetic Recombination;Goals;Health;Human;Hypersensitivity;in vivo;in vivo imaging;inflammatory pain;Interneurons;Intervention;Investigation;inward rectifier potassium channel;Knowledge;Label;Leucine Enkephalin;Ligands;Light;Mediating;midbrain central gray substance;Molecular;Morphine;mu opioid receptors;Mus;neural;neural circuit;Neural Pathways;Neurons;Neuropeptides;Nociception;novel;Opioid;Opioid Analgesics;opioid epidemic;Opioid Peptide;Opsin;optogenetics;Overdose;overexpression;Pain;Pain management;Pain Measurement;pain perception;pain relief;Pattern;Peptides;Persistent pain;Persons;Pharmaceutical Preparations;pharmacologic;Photometry;Population;postsynaptic;pre-clinical;prescription opioid;presynaptic;Process;promoter;Property;Prosencephalon;Quality of life;recruit;Research;response;Rewards;Risk;Role;sensor;Signal Transduction;Site;Stimulus;Structure;System;targeted treatment;temporal measurement;Testing;therapy outcome;Time;tool;Training;transmission process;Virus;Work

PROJECT_TITLE: Investigation of nociceptive endogenous opioid dynamics in the periaqueductal gray


ADMINISTERING_IC: VA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: Veterans Affairs

ORG_CITY: CHICAGO

ORG_NAME: JESSE BROWN VA MEDICAL CENTER

ORG_STATE: IL

PHR: For Veterans with leg amputation, comfort during daily use of their prosthesis is of paramount importance. Comfort can affect the satisfaction with their prosthesis, use of their prosthesis, and ultimately their mobility and independence. There is some limited evidence to suggest that comfort is directly linked to the pressures experienced by the amputated limb while in the prosthetic socket and that these pressures are affected by how forces are transferred from the ground to the amputated limb. The way in which those pressures are applied to the amputated limb can be influenced by the position of the prosthesis, but also by the flexibility of the prosthesis. The aim of this study is to help us better understand the relationships between prosthesis user comfort, pressures applied to the amputated limb, and prosthetic foot flexibility to improve Veterans’ experience using a leg prosthesis. We will use a new robotic prosthesis to study those relationships and test the possibility of using pressures applied to the amputated limb to automatically adjust prosthesis flexibility to improve comfort.

PI_NAMEs: MAJOR, MATTHEW J. (contact)

PROJECT_TERMS: Affect;Algorithms;Amputation;Anatomy;Ankle;ankle prosthesis;Artificial Leg;Award;Biofeedback;Clinical;clinical encounter;community reintegration;cost;curve fitting;Development;Devices;Distal;efficacy evaluation;Elasticity;Exertion;experience;feasibility testing;Feedback;flexibility;foot;Foundations;Future;Gait;Guidelines;human-in-the-loop;improved;interest;Intervention;kinematics;Leg;limb amputation;limb loss;Link;Lower Extremity;Maps;Measures;mechanical properties;Methods;Modeling;novel;Outcome;Pain;Pain Threshold;Participant;Patient Self-Report;Performance;Pilot Projects;Positioning Attribute;pressure;pressure sensor;primary outcome;Process;Property;Prosthesis;prosthesis wearer;prosthetic alignment;prosthetic foot;prosthetic socket;Protocols documentation;Psychophysics;Publishing;Reaction;Reference Values;Reporting;Research;Research Project Grants;Resolution;response;Robotics;satisfaction;secondary outcome;service member;socket design;stressor;Surveys;System;Techniques;Testing;Time;time use;Tissues;transmission process;Veterans;Vietnam;Visit;Walking;Work

PROJECT_TITLE: Mapping ankle-foot stiffness to socket comfort and pressure using a robotic emulator platform to personalize prosthesis function via human-in-the-loop optimization

STUDY_SECTION: RRDS

STUDY_SECTION_NAME: Rehabilitation Research and Development SPiRE Program[RRDS]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Digestive Diseases;Endocrine Disruptors;Estrogen;Genetics;Liver Disease;Microbiome;Nutrition;Obesity;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: NARRATIVE It is unclear how the long-lasting effects of environmental exposure persist across generations and contribute to chronic diseases in later life. We use inorganic arsenic as a prototype environmental chemical to dissect the epigenetic inheritance mechanisms in animal models. The mechanistic insights from this study will advance our understanding of the cross-generational effects of environmental exposure on metabolic physiology through the disruption of the endocrine system.

PI_NAMEs: SUN, ZHENG  (contact)

PROGRAM_OFFICER_NAME: SCHUG, THADDEUS

PROJECT_TERMS: Address;Adipose tissue;Affect;Age;Air Pollution;Animal Model;Arsenic;bisulfite sequencing;Blood;Brain;C57BL/6 Mouse;Chemicals;Chronic Disease;comparison control;Developed Countries;Development;Diabetes Mellitus;disease registry;DNA Methylation;drinking water;Dyslipidemias;Eating;Endocrine disruption;Endocrine system;Energy Metabolism;environmental chemical;Environmental Exposure;Enzymes;Epidemic;Epigenetic Process;ESR1 gene;Estradiol;Estrogen Receptors;Estrogens;Etiology;Exposure to;Fatty acid glycerol esters;fatty acid oxidation;fecal transplantation;Female;Food Energy;Gene Expression;Generations;Genes;Germ-Free;Glucose;Glucose Intolerance;glucose metabolism;glucose production;Gonadal Hormones;Growth;gut microbiome;Hazardous Substances;Hepatic;Hepatocyte;hormonal signals;Hypothalamic structure;Industrialization;insight;intergenerational;Knockout Mice;late life;Lead;Length;lipid biosynthesis;lipid metabolism;Lipids;Liver;Malabsorption Syndromes;male;Mammals;Masks;Metabolic;metabolic phenotype;Metabolic syndrome;Metabolism;Methylation;microbiome;microbiome alteration;Molecular;mouse model;Mus;Muscle;Nonesterified Fatty Acids;Nutrient;nutrient absorption;Obesity;offspring;Ovariectomy;pharmacologic;Phenotype;Physiology;Pituitary Gland;pituitary gonadal axis;Poison;Pollution;Predisposition;prenatal exposure;prototype;Role;sex;Signal Transduction;Solid;sperm cell;transcriptomics;Triglycerides;Untranslated RNA;Urbanization;wasting;Water Pollution;whole genome;zygote

PROJECT_TITLE: Inter- and transgenerational effects of paternal arsenic exposure

STUDY_SECTION: SIEE

STUDY_SECTION_NAME: Systemic Injury by Environmental Exposure[SIEE]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Immunization;Immunotherapy;Nanotechnology;Neurosciences;Orphan Drug;Rare Diseases;Vaccine Related

ORG_CITY: GAINESVILLE

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Narrative Despite maximal surgery, radiation and chemotherapy, glioblastoma (GBM) remains invariably recalcitrant, and necessitates development of new therapies. We have developed a novel FDA-IND approved agent (BB-19304, Sayour) utilizing RNA-nanoparticles (RNA-NPs) to reprogram innate/adaptive immunity against GBM. In this proposal, we will explore the mechanistic underpinnings of RNA-NP mediated response in murine/large animal models before pursuing a first-in-human clinical trial.

PI_NAMEs: SAYOUR, ELIAS  (contact)

PROGRAM_OFFICER_NAME: HENDERSON, LORI A

PROJECT_TERMS: Acute;adaptive immunity;Adjuvant;Animal Model;Animals;arm;Biological;Biological Response Modifiers;Biopsy;Blood;Blood - brain barrier anatomy;blood-brain barrier crossing;Canis familiaris;CCL2 gene;CD8-Positive T-Lymphocytes;cell type;Cells;Cellular Immunity;Chemotherapy and/or radiation;Chronic;Clinical;Clinical Trials;Clinical Trials Design;clinically relevant;cohort;cytokine;Data;Dendritic Cells;Development;Dose;effective therapy;Evaluation;Excision;experimental study;first-in-human;Formulation;genetic signature;Glioblastoma;Glioma;H3 K27M mutation;Heterogeneity;Hour;Human;IACUC;IFIH1;IFNAR1 gene;Immune;Immune checkpoint inhibitor;Immune system;Immunity;Immunocompetent;immunogenic;immunogenicity;Immunologics;immunoregulation;Immunosuppression;Immunotherapeutic agent;Immunotherapy;improved;interest;Interferon alpha;Interferons;intravenous administration;knockout animal;Knockout Mice;Lipids;Long-Term Survivors;Luciferases;manufacture;Mediating;Memory;Messenger RNA;Modeling;Mus;nano;nanoparticle;Neoadjuvant Therapy;new technology;novel;novel therapeutics;novel vaccines;Operative Surgical Procedures;particle;pathogen;Pathway interactions;Patients;phase 1 designs;programs;Randomized;receptor;Recurrence;Resistance;response;RNA;Safety;Serum;Signal Transduction;survival outcome;T memory cell;T-Cell Activation;T-Lymphocyte;targeted treatment;Technology;Toll-like receptors;Toxic effect;trafficking;Translations;trial design;tumor;tumor microenvironment;Tumor-Derived;tumor-immune system interactions;vaccine immunotherapy;vaccine response;Vaccines;Viral;Viremia

PROJECT_TITLE: Overcoming the blood-brain barrier with nanoparticle vaccines against gliomas

STUDY_SECTION: CII

STUDY_SECTION_NAME: Cancer Immunopathology and Immunotherapy Study Section[CII]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Comparative Effectiveness Research;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Infectious Diseases;Nutrition;Prevention

ORG_CITY: ITHACA

ORG_NAME: ASCRIBE BIOSCIENCE INC.

PHR: Narrative Edible sprouts pose a high risk for outbreaks of foodborne illnesses that typically originate in the seeds due to trace amounts of human enteric pathogens, which thrive under the warm, humid conditions needed for sprout production. Ascribe Bioscience is developing a novel sprout treatment product based on a natural molecule that activates plant defenses, offering reliable long-term protection against a broad range of bacterial pathogens. Successful development of this innovation has the potential to dramatically improve the safety of edible sprouts and reduce the incidence of sprout-related foodborne illness outbreaks, by uniquely conferring protection that begins at the seed stage and persists through growth, harvest, and up to the point of consumption.

PI_NAMEs: DEJONGHE, WIM  (contact)

PROGRAM_OFFICER_NAME: ALEXANDER, WILLIAM A

PROJECT_TERMS: Address;Affect;Alfalfa;antimicrobial;Appearance;Bacteria;Bacterial Counts;Biological Sciences;Calcium;Cessation of life;Clover;commercialization;compare effectiveness;Consumption;defense response;Development;Disease;Disease Outbreaks;Dose;Effectiveness;efficacy testing;Enteral;enteric pathogen;Escherichia coli O157:H7;experience;Food Safety;foodborne;foodborne illness;foodborne outbreak;Formulation;Germination;Growth;Harvest;hazard;Health Hazards;high risk;Hospitalization;Human;human pathogen;Hypochlorite;improved;Incidence;Industry;Industry Standard;Infection;Infiltration;innovation;large scale production;Link;Measures;Methodology;Methods;microbial;Microbial Biofilms;microbiome;mung bean;new technology;novel;Nutrient;pathogen;pathogenic bacteria;Phase;Plants;Powder dose form;prevent;prevent outbreaks;Process;Production;Proliferating;Public Health;Recommendation;Research;Resistance;Risk;Role;Safety;Sales;Salmonella;scale up;Smell Perception;Source;standard care;System;Taste Perception;Technology;Testing;Time;Tissues;Toxic effect;Toxicology;treatment duration;treatment effect;Treatment Efficacy

PROJECT_TITLE: Preventing outbreaks of foodborne pathogenic bacteria in edible sprouts via novel resistance-conferring seed treatments

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AIDC-V(13)]


NIH_SPENDING_CATS: Behavioral and Social Science;Cannabinoid Research;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Substance Misuse

ORG_CITY: WINSTON-SALEM

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

ORG_STATE: NC

PHR: Project Narrative Cannabis edibles pose unique public health challenges as they are packaged as appealing food products and may be perceived as less harmful than smoking cannabis, despite the greater danger of severe intoxication. Because their psychoactive effects are delayed and longer lasting, it is difficult for users to titrate their dose which can result in the overconsumption of high amounts of tetrahydrocannabinol (THC) and acute adverse consequences. This project will address gaps in our understanding of how edibles package marketing contributes to harm perceptions and risk for overconsumption and how to effectively communicate knowledge about safe consumption through package warnings to guide state policymakers as they establish state regulatory guidelines for cannabis edibles to minimize harms and protect public health.

PI_NAMEs: REBOUSSIN, BETH A. (contact)

PROGRAM_OFFICER_NAME: ROMBERG, ALEXA RUTH

PROJECT_TERMS: Acute;Address;Adult;adverse outcome;American;Area;Attention;Automobile Driving;Back;Cannabis;cardiovascular effects;Cardiovascular system;cognitive interview;Colorado;Communication;Comprehension;Consumption;Coupled;Data;Descriptor;design;Diet Habits;Dose;Effectiveness;Elements;Empirical Research;Experimental Designs;experimental study;Food;Growth;Guidelines;Harm Reduction;Health;Hospitalization;Hour;Image;Imagery;Industry;Inhalation;Intoxication;Knowledge;Lead;Legal;Libraries;marijuana legalization;Marijuana Smoking;marijuana use;Marketing;Metabolism;Myocardial Infarction;National Institute of Drug Abuse;Outcome;Perception;Persons;Policy Maker;Product Packaging;Proliferating;Psychoses;psychotic;Public Health;public health research;Recommendation;Recreation;Regulation;Research;Research Priority;Risk;risk perception;Sales;Sampling;sex;Smell Perception;Smoke;Symptoms;Testing;Tetrahydrocannabinol;Text;Titrations;Toxic effect;United States;Variant;Ventricular;Visual;Visual attention;Weight;willingness

PROJECT_TITLE: The Impact of Product Packaging on Appeal, Knowledge and Risk Perceptions of Cannabis Edibles

STUDY_SECTION: CIHB

STUDY_SECTION_NAME: Community Influences on Health Behavior Study Section[CIHB]


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Clinical Trials and Supportive Activities;Crohn's Disease;Digestive Diseases;Genetics;Inflammatory Bowel Disease

ORG_CITY: LEXINGTON

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: The importance of understanding the role of mitochondrial respiration in ulcer healing and determining clinical phenotypes in inflammatory bowel disease has been recently strengthened by major prospective clinical studies in pediatric Crohn’s (Kugathasan et al Lancet) and ulcerative colitis (Haberman) patients. Studies proposed here use a novel genetically-engineered mouse model of mitochondrial deficiency in combination with single cell RNAseq analysis of normal and diseased (CD/UC) patients. We posit this work will identify key mechanisms that underlie the cause of nonhealing ulceration in IBD with the goal of identifying targets for new drug development.

PI_NAMEs: BARRETT, TERRENCE A. (contact)

PROGRAM_OFFICER_NAME: GREENWEL, PATRICIA

PROJECT_TERMS: beta catenin;Biochemical;Biogenesis;Biopsy;Childhood;Chronic;chronic ulcer;Clinical;Clinical Data;clinical phenotype;Clinical Research;Colitis;Crohn's disease;crypt cell;Data;dextran sulfate sodium induced colitis;Disease;Disease Outcome;Disease remission;Drops;drug development;Epithelial Cells;experience;Failure;Gene Expression;Generations;Genes;Genetic Transcription;Genetically Engineered Mouse;Goals;healing;Human;In Vitro;Inflammation;Inflammatory Bowel Diseases;infliximab;Injury;intestinal epithelium;Intestines;Investigation;Knockout Mice;Leukocyte L1 Antigen Complex;Maintenance;Measures;Mitochondria;Modeling;Monoclonal Antibodies;Mucositis;Mucous Membrane;Mus;new therapeutic target;novel;novel strategies;Operative Surgical Procedures;Outcome;Oxidation-Reduction;Pathogenesis;Patients;Phosphatidylinositols;Phosphotransferases;prevent;Principal Investigator;Procedures;programs;prospective;PTEN gene;Refractory;repaired;Respiration;Respiratory Chain;response;Role;Signal Transduction;single-cell RNA sequencing;Site;stem cells;Tattooing;Testing;therapeutic biomarker;therapeutic target;TNF gene;transcriptomics;Treatment Efficacy;Ulcer;Ulcerative Colitis;Visualization;WNT Signaling Pathway;Work

PROJECT_TITLE: The Role of Crypt Fissioning in IBD Ulcer Healing

STUDY_SECTION: GMPB

STUDY_SECTION_NAME: Gastrointestinal Mucosal Pathobiology Study Section[GMPB]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Brain Disorders;Emerging Infectious Diseases;Infectious Diseases;Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: STANFORD

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: PROJECT NARRATIVE Enteroviruses are ubiquitous pathogens causing a number of important human diseases including respiratory disease, hand foot and mouth disease, myocarditis, and acute flaccid myelitis. Outbreaks of non-poliovirus enteroviruses such as EV-D68 and EV-A71 cause severe neuropathology in children. Our contributions will have wide-reaching impacts as the identified cellular genes and molecular mechanisms are likely to provide new targets for therapeutic interventions, in addition to fundamentally advancing the fields of viral neuropathogenic disease modeling and stem cell engineering.

PI_NAMEs: CARETTE, JAN E (contact);PASCA, SERGIU

PROGRAM_OFFICER_NAME: PARK, EUN-CHUNG

PROJECT_TERMS: 3-Dimensional;acute flaccid myelitis;Address;Affect;Anti-viral Therapy;Astrocytes;Biological Assay;Biology;Cell Communication;Cell Line;Cell Lineage;cell type;Cells;Central Nervous System;Cerebral cortex;Child;Clustered Regularly Interspaced Short Palindromic Repeats;Cortical Cord;Cytoprotection;Cytosol;Disease;disease model;Disease Outbreaks;Encephalitis;Endocytosis;engineered stem cells;Enterovirus;Enterovirus 68;Enterovirus 71;Enterovirus Infections;Enzymes;Foot Diseases;Foundations;Genes;Genetic;Genetic Screening;Genome;genome-wide;Goals;Hand's disease;hindbrain;Human;human disease;Human poliovirus;human stem cells;Huntington gene;Immune response;In Vitro;in vivo;Individual;Infection;Infectious Agent;insight;Integration Host Factors;Knock-out;Knowledge;Laboratories;Learning;Life;Mediating;Medical;Meningitis;Modeling;Molecular;Motor;Motor Neurons;mouse model;Mouth Diseases;Movement;Mus;Muscle;Muscle Contraction;Muscle Fibers;Myocarditis;Names;neonatal infection;Nervous System;neural;Neurologic;neuromuscular;Neuromuscular Junction;Neurons;Neuropathogenesis;neuropathology;Neurosciences;neurotropic;Neurotropism;new outbreak;new therapeutic target;novel;novel strategies;Oligodendroglia;Organoids;overexpression;Paralysed;pathogen;Pathogenesis;Phospholipase;Physiological;Pluripotent Stem Cells;Poliomyelitis;Preparation;Process;Proteins;Publishing;receptor;Regulation;Respiratory Disease;Rodent;Role;Series;Site;Skeletal Muscle;Spinal Cord;stem cell biology;Synapses;System;Therapeutic Intervention;Tissues;transcriptomics;translational potential;Tropism;Viral;Viral meningitis;Virus;Virus Diseases;virus host interaction;Virus Receptors;Work

PROJECT_TITLE: Human 3D neuro-muscular assembloids to study cell tropism and host factor utilization of divergent neuropathogenic enteroviruses


PHR: Project Narrative Therapeutic combinations targeting autophagy appear promising for melanoma and other cancers, and we have discovered that alterations in lipid rafts are associated with resistance to autophagy-modulating therapies. This proposal will address a major unanswered question: Can targeting therapy-induced lipid raft assembly enhance the efficacy of autophagy-modulating therapy? Knowledge gleaned from this work will provide a fundamental understanding of how autophagy inhibition can be used most effectively in the clinic and may provide a new combination therapy approach that can improve cancer patient survival in the future.

PI_NAMEs: AMARAVADI, RAVI K (contact);GOLDMAN, AARON ROBERT

PROGRAM_OFFICER_NAME: COVELL, DAVID G

PROJECT_TERMS: Address;Advanced Malignant Neoplasm;anti-PD1 antibodies;anti-tumor agent;Antigen Presentation;Autophagocytosis;Biotechnology;BRAF gene;cancer clinical trial;Cancer Model;Cancer Patient;cancer therapy;CD8-Positive T-Lymphocytes;Cell Death;Cell membrane;Cell Survival;Cell-Mediated Cytolysis;Cells;Ceramide glucosyltransferase;Chemicals;chemotherapy;Cholesterol;Clinic;Clinical;Clinical Data;Clinical Trials;clinically relevant;Collaborations;Combined Modality Therapy;comparison control;Development;enzyme pathway;Enzymes;Exhibits;experimental study;extracellular;FDA approved;first-in-human;Future;Generations;Genes;genetic manipulation;Glean;humanized mouse;Hydroxychloroquine;Immune;Immune checkpoint inhibitor;Immunotherapy;improved;improved outcome;in vivo;in vivo Model;inhibition of autophagy;inhibitor;Institution;Knowledge;lipid metabolism;lipidome;Lipids;Low Density Lipoprotein Receptor;Lysosomes;Macrophage;Malignant neoplasm of pancreas;Malignant Neoplasms;MAP Kinase Gene;Measures;MEK inhibition;MEKs;Melanoma;Melanoma Cell;Melanoma patient;Membrane Microdomains;Metabolic;Modeling;mouse model;mutant;neoplastic cell;new combination therapies;novel;novel therapeutic intervention;novel therapeutics;Oncologist;overexpression;palmitoyl-protein hydrolase;Pathway interactions;patient derived xenograft model;Patient-Focused Outcomes;Patients;phase I trial;phase II trial;Phenotype;pre-clinical;Pre-Clinical Model;preclinical study;Proteins;Randomized;reconstitution;recruit;Regimen;Resistance;Resistance development;resistance mechanism;response;Role;Sampling;Source;Sphingolipids;SR-B proteins;standard of care;Systems Biology;T-Cell Activation;targeted agent;targeted treatment;Testing;Therapeutic;therapy outcome;Toxic effect;tumor;tumor growth;Tumor Immunity;Tumor-associated macrophages;Work

PROJECT_TITLE: Resistance mechanisms to autophagy-modulating therapies


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Nutrition;Obesity;Prevention

PHR: Project Narrative (Public Health Relevancy Statement) Obesity trends may be the result of failure to sustain weight loss maintenance (WLM); therefore, there is an urgent need to test new bio-behavioral strategies to prevent weight regain. Time-restricted eating (TRE), reducing the eating window to 6–10 hours per day, is an untested bio-behavioral strategy that may be helpful for WLM. This proposal seeks to develop and TRE intervention and test efficacy for preventing weight regain following successful weight loss in a free-living setting.

PI_NAMEs: POPP, COLLIN JEFFREY (contact)

PROGRAM_OFFICER_NAME: DONZE, LAURIE FRIEDMAN

PROJECT_TERMS: Acceleration;acceptability and feasibility;Acylation;Address;Adherence;Adult;analog;arm;Award;Behavior;behavior change;Behavioral;biobehavior;Biological;Biological Markers;Body Composition;Body mass index;Body Weight;Body Weight decreased;Caloric Restriction;Chronic Disease;Clinic;community barrier;Conduct Clinical Trials;Control Groups;Counseling;Data;design;Desire for food;Development;Diet Monitoring;Dietary intake;direct application;Eating;efficacy evaluation;efficacy testing;energy balance;Energy Metabolism;Enrollment;Environment;Evaluation;Exclusion;experience;Failure;Family;family structure;Fatty acid glycerol esters;feasibility testing;Feedback;Foundations;Gastric Inhibitory Polypeptide;ghrelin;glucagon-like peptide 1;Goals;Guidelines;Health;Hour;Hunger;improved;Individual;innovation;Insulin;Intermittent fasting;Intervention;Interview;Leptin;lifestyle intervention;Maintenance;Measurement;Measures;Mentors;Mentorship;Methods;Motivation;Muslim religion;Neighborhoods;Non-Insulin-Dependent Diabetes Mellitus;Nutritional Study;Obesity;Occupations;oxidation;Participant;Pathway interactions;Phase;Physiological;Physiology;Pilot Projects;Policies;prevent;primary outcome;programs;Provider;Public Health;Publications;Randomized;Randomized, Controlled Trials;Recommendation;recruit;reduced food intake;Research;Research Personnel;response;Rest;Role;Running;Satiation;skill acquisition;smartphone application;Strategic Planning;success;Testing;theories;Time;Time-restricted feeding;tool;Training;trend;United States National Institutes of Health;Visual;Weight;weight loss program;Weight maintenance regimen;Writing

PROJECT_TITLE: Time-restricted eating: Is it an efficacious tool for weight loss maintenance

STUDY_SECTION: MTI

STUDY_SECTION_NAME: NHLBI Mentored Transition to Independence Study Section[MTI(OA)]


NIH_SPENDING_CATS: Cardiovascular;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Heart Disease - Coronary Heart Disease;Human Genome;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: K01 – Project Narrative Investigating the genetic underpinning of circulating meabolitess associated with coronary heart disease in African Americans will help to define the mechanisms by which coronary heart disease develops. It will also help to better predict which patients are at increased risk of developing this disease. Focused on an understudied group, we aim to improve health outcomes by providing more personalized risk assessment for coronary heart disease.

PI_NAMEs: CRUZ, DANIEL  (contact)

PROGRAM_OFFICER_NAME: WANG, WAYNE C

PROJECT_TERMS: Address;Admixture;admixture mapping;African;African American;African American population;African ancestry;Alleles;Amino Acids;Biological;Biomedical Research;Cardiology;cardiometabolic risk;cardiometabolism;Cardiovascular Diseases;Cardiovascular system;Caring;causal variant;Chronic Disease;circulating biomarkers;Clinical;clinical risk;cohort;Communities;Complex;Coronary heart disease;Data;Diabetes Mellitus;dietary;Discrimination;Disease;disease phenotype;Etiology;European;European ancestry;Exhibits;experience;follow-up;Foundations;Future;Gene Frequency;Genes;Genetic;genetic analysis;genetic association;Genetic Drift;genetic makeup;genetic selection;genetic variant;Genetic Variation;Genome;genome wide association study;genome-wide analysis;Genomic Segment;Genomics;geographic difference;Goals;Health;heart disease risk;High Density Lipoproteins;high risk;Hyperlipidemia;Hypertension;improved;Individual;Institution;interest;Israel;Jackson Heart Study;Laboratories;liquid chromatography mass spectrometry;Low-Density Lipoproteins;Maps;Measures;Medical;Medical center;medical schools;member;metabolomics;Methods;Minority Groups;multi-ethnic;Multi-Ethnic Study of Atherosclerosis;multidisciplinary;multiple omics;novel;Obesity;Outcome;Participant;Pathogenesis;Pathway interactions;Patients;Pattern;personalized care;Persons;Plasma;Population;precision medicine;Predictive Value;Preventive;Probability;psychosocial;Publishing;Quantitative Trait Loci;Research;Resources;Risk;Risk Assessment;Risk Factors;Risk Marker;Sampling;Signal Transduction;Societies;Socioeconomic Factors;Structure;Techniques;Technology;Testing;Training;trait;Triglycerides;Underserved Population;United States;Variant;whole genome;Work

PROJECT_TITLE: Admixture Mapping of Coronary Heart Disease and Associated Metabolomic Markers in African Americans


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Emerging Infectious Diseases;Genetics;Infectious Diseases;Rare Diseases;Stem Cell Research;Stem Cell Research - Embryonic - Human;Vector-Borne Diseases

ORG_NAME: ROCKEFELLER UNIVERSITY

PHR: 5-methylcytosine (m5C) is an understudied but important RNA modification, often dysregulated in developmental disorders, cancer and more. We propose a comprehensive study exploiting RNA viruses whose genomes are m5C methylated to understand the role of m5C in regulating RNA biology, including the activities responsible for adding and recognizing this modification. In addition to significantly advancing the m5C field, this work will also contribute to the development of antiviral strategies against viruses causing significant human disease such as chikungunya virus and Coxsackie virus.

PI_NAMEs: RICE, CHARLES M (contact)

PROJECT_TERMS: 5' Untranslated Regions;Acute;Address;Affect;Alpha Virus;Animal Model;antiviral drug development;Attenuated;Binding;Binding Proteins;Biochemical;Biological Assay;Biology;bisulfite;Capsid Proteins;Cardiac;Cell Physiology;cell type;Cells;Cellular biology;Chikungunya virus;Chronic;Clover;Code;Coxsackie Viruses;Data;Deposition;developmental disease;epitranscriptome;Excision;Exhibits;Family;Family member;Genetic Transcription;Genome;Goals;High-Throughput Nucleotide Sequencing;Homeostasis;Human Biology;human disease;immune activation;Immune Evasion;Immunocompetent;Immunology;In Vitro;in vivo;Infection;Innate Immune Response;innate immune sensing;insight;Intervention;Knock-out;Knowledge;Learning;Life Cycle Stages;Malignant Neoplasms;Mass Spectrum Analysis;Measures;Methylation;Methyltransferase;Modification;Molecular;mouse model;mRNA Translation;mutant;Mutate;Mutation;Myocarditis;neuron development;novel;Outcome;overexpression;Pathogenesis;pathogenic virus;Plant Leaves;Play;Post-Transcriptional RNA Processing;Process;Proteins;Reader;reconstitution;Regulation;Research;Ribosomal RNA;RNA;RNA methylation;RNA Virus Infections;RNA Viruses;Role;Sindbis Virus;Site;Specificity;stem cell differentiation;stem cells;Structure;System;Testing;Transfer RNA;Translation Initiation;Translations;tRNA Methyltransferases;Viral;Viral Genome;viral myocarditis;Viral Nonstructural Proteins;Viral Pathogenesis;Viral Physiology;viral RNA;Virion;Virus;Virus Diseases;virus host interaction;Virus Replication;Work

PROJECT_TITLE: Employing viruses to unravel the functional significance of the m5C epitranscriptome

STUDY_SECTION: VIRA

STUDY_SECTION_NAME: Virology - A Study Section[VIRA]


NIH_SPENDING_CATS: Behavioral and Social Science;Biomedical Imaging;Cardiovascular;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Precision Medicine;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: PROJECT NARRATIVE  Transthyretin V122I, is a highly penetrant mutation for hereditary transthyretin amyloid cardiomyopathy (hATTR-CM) that is common in African Americans and Hispanic Americans. Recent therapies have been approved to treat hATTR-CM, which have led to decreased mortality; thus, understanding who will develop hATTR-CM, accurate identification of V122I carriers and understanding hidden disease burden is important. In this proposal, we examine the population health impact of V122I using polygenic risk scores, machine learning approaches on electronic health records, and patient recall by genotype, which can lead to new population health strategies for heart failure in racial and ethnic minorities.

PI_NAMEs: DO, RON  (contact);NADKARNI, GIRISH NITIN

PROGRAM_OFFICER_NAME: JAQUISH, CASHELL E

PROJECT_TERMS: Address;Adopted;African American population;African ancestry;African Caribbean;Age;American Medical Association;Amyloid;Amyloid deposition;Amyloid Fibrils;biobank;burden of illness;Cardiac;Cardiomyopathies;Cardiovascular system;clinical care;clinical risk;Clinical Trials;Complex;Data;data repository;Deposition;Diagnosis;Diphosphates;Disease;Documentation;Echocardiography;Electronic Health Record;Environment;ethnic disparity;ethnic minority;Future;Genes;Genetic;Genotype;Germ-Line Mutation;Goals;Grant;Health system;Healthcare Systems;Heart failure;heart imaging;Hispanic Americans;Hospitalization;Image;Image Analysis;improved;Individual;Inherited;innovation;insight;Journals;Knowledge;Learning;Link;Machine Learning;Magnetic Resonance;Mediating;Medicine;Methods;Minority Groups;Morbidity - disease rate;mortality;multi-ethnic;multimodal data;multimodality;Mutation;Myocardial;Myocardium;Nuclear;Onset of illness;Patients;Penetrance;Pennsylvania;Phenotype;polygenic risk score;Population;population health;Prealbumin;precision medicine;Qualifying;Quality of life;racial disparity;racial minority;Recontacts;Research;Risk;Risk Factors;risk stratification;scale up;Scanning;screening;Single Nucleotide Polymorphism;Structure;Supportive care;targeted treatment;Technetium;Technetium 99m;Testing;tool;trait;underserved minority;Universities;Work

PROJECT_TITLE: Elucidating hereditary transthyretin-mediated heart failure risk using machine learning, polygenic risk and recall by genotype approaches in African ancestry individuals

STUDY_SECTION: CICS

STUDY_SECTION_NAME: Clinical and Integrative Cardiovascular Sciences Study Section[CICS]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Neurosciences

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Project Narrative The proposed research is relevant to public health because understanding the circuit, synaptic and molecular mechanisms by which subcortical circuitry supports wakefulness is ultimately expected to increase understanding of how wakefulness and associated electrographic rhythms are produced and maintained. As such the proposed research is relevant to the part of NIH’s mission that pertains to developing fundamental knowledge that may yield improved pharmacologic approaches and interventional strategies, and thereby reduce the burdens of human disability, in not only arousal-based disorders such as coma, but also in a host of neuropsychiatric and neurodegenerative disorders, including Alzheirmer’s disease, Parkinson’s disease, schizophrenia and the cognitive impairments of normal aging.

PI_NAMEs: FULLER, PATRICK M (contact)

PROGRAM_OFFICER_NAME: HE, JANET

PROJECT_TERMS: Alzheimer's Disease;Animals;Anti-Cholinergics;Arousal;Award;basal forebrain;basal forebrain cholinergic neurons;base;Behavioral;Brain;burden of illness;Cells;cellular targeting;cholinergic;Cholinergic Agents;cholinergic neuron;Cognition;Coma;Conscious;Data;disability;Disease;Dissection;Electroencephalography;experience;Functional disorder;Genetic;Glutamates;Goals;Human;Hypothalamic structure;Impaired cognition;improved;In Situ Hybridization;in vivo;Individual;innovation;Intervention;Knowledge;Lateral;Lesion;Maintenance;Maps;Mission;Modeling;Molecular;Molecular Genetics;Nervous System Disorder;neural network;neurobehavioral;Neurobiology;neurochemistry;Neurodegenerative Disorders;Neurons;neuropsychiatric disorder;normal aging;novel;novel therapeutics;Optics;optogenetics;Outcome;Output;Parkinson Disease;Patients;Performance;pharmacologic;Photometry;Physiology;Population;postsynaptic;presynaptic;Process;Public Health;rabies viral tracing;Research;restoration;Role;Schizophrenia;Scientist;Sleep Wake Cycle;Source;Stupor;Synapses;System;Testing;therapy development;Time;United States National Institutes of Health;Wakefulness;Work

PROJECT_TITLE: Molecular-Genetic Dissection of Subcortical Circuitry Regulating Arousal

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


NIH_SPENDING_CATS: Bioengineering;Neurosciences

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative: Auditory Mechanics and Cochlear Amplification 2020 The ear's ability to discriminate frequencies is fundamental to hearing; this ability is based in the cochlear amplifier, a cell-based, electromechanical engine that is both powerful and fragile. The cochlear amplifier degrades due to aging, illness, from exposure to loud sounds, and following some treatments for infection and cancer. This project uses purpose-built sensors and sensing techniques to probe the constellation of factors that is required for healthy cochlear amplification, and to understand how the amplifier fails -- in order to advance our ability to treat hearing loss and to devise strategies to reduce it.

PI_NAMEs: OLSON, ELIZABETH S. (contact)

PROGRAM_OFFICER_NAME: CYR, JANET

PROJECT_TERMS: Abbreviations;Action Potentials;Affect;Aging;Amplifiers;Anatomy;Attention;Auditory;base;career;Cavia;Cells;Cochlea;Cochlear duct;Collagen Fiber;collagenase;Communication;Complex;Contracts;Coupling;Deterioration;Development;Drama;Drops;Ear;ear muscle;Endolymph;experimental study;Exposure to;External auditory canal;extracellular;fascinate;Feedback;Fiber Optics;Frequencies;Gerbils;Hair;Hair Cells;Hearing;hearing impairment;hearing range;Image;In Vitro;in vivo;Infection;Infiltration;Injections;Inner Hair Cells;insight;Liquid substance;Loudness;Malignant Neoplasms;Maps;Measurement;Measures;mechanical properties;Mechanics;middle ear;Modeling;Molecular Weight;Motion;Muscle;Mutant Strains Mice;Mutation;Neurons;Optical Coherence Tomography;Organ of Corti;Outer Hair Cells;Pattern;Penetration;Phase;Physiologic pulse;Play;Polyethylene Glycols;Porosity;pressure;Proteins;Radial;Resolution;response;Rodent;Role;round window;sensor;Sensory;signal processing;Signal Transduction;Solid;Sorting;sound;sound frequency;Source;Speed;Stimulus;Structure;Techniques;Technology;tectorial membrane;tensor tympani muscle;Testing;Time;Tissues;Training;transmission process;Travel;Tympanic membrane;Viscosity;voltage;Work

PROJECT_TITLE: Auditory Mechanics and the Cochlear Amplifier 2020


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Embryonic - Non-Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: Project Narrative The utility of patient-specific pluripotent stem cells (PSCs) for the study of development and disease is compromised by the frequent introduction of aberrant chromatin marks in these cells. The aim of this proposal is to better understand the molecular reasons for these abnormalities and to develop novel approaches that prevent their occurrence. Our work will facilitate the rational design of improved protocols for the generation and propagation of high-quality stem cell lines for a wide range of biomedical applications.

PI_NAMEs: STADTFELD, MATTHIAS  (contact)

PROGRAM_OFFICER_NAME: SALAZAR, DESIREE LYNN

PROJECT_TERMS: Aberrant DNA Methylation;Affect;Alleles;analysis pipeline;Biological Assay;Biological Markers;causal variant;Cell Line;cell type;Cells;Chromatin;Chromosome 13;Chromosome Mapping;Complex;Degenerative Disorder;Development;Developmental Gene;Diagnostic;Disease;DNA;DNA Methylation;epigenetic marker;Epigenetic Process;epigenetic regulation;epigenome;Essential Genes;Event;Exhibits;Future;Gene Cluster;Gene Expression;gene product;Generations;Genes;Genetic;genetic approach;Genetic Determinism;Genetic Heterogeneity;Genetic Models;genetic regulatory protein;genetic variant;Genetic Variation;Genome;Genome engineering;genome-wide;Genomic Imprinting;genomic locus;Genomics;Goals;Health;Human;human disease;human pluripotent stem cell;Hybrids;Hypermethylation;Impairment;imprint;improved;Inbred Mouse;insight;Maintenance;Mammals;Maps;Mediating;Methylation;Modeling;Molecular;mouse genetics;Mouse Strains;Mus;novel;novel strategies;Patients;Pluripotent Stem Cells;Population;Predisposition;preservation;prevent;Process;protective allele;Protocols documentation;Quantitative Trait Loci;rational design;Regulation;Reporter;Reporter Genes;risk prediction;Signal Pathway;Somatic Cell;stem cells;Susceptibility Gene;Syndrome;System;Testing;Therapeutic;Trans-Activators;Transcription Repressor;Transgenic Organisms;Variant;Work

PROJECT_TITLE: Dissecting genetic determinants of epigenetic instability in pluripotent stem cells

STUDY_SECTION_NAME: Development - 2 Study Section[DEV2]


NIH_SPENDING_CATS: Genetics;Neurosciences;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_DEPT: BIOCHEMISTRY

PHR: Project Narrative Developmental patterning is a crucial biological mechanism perturbations of which are related to a plethora of developmental disorders. Developmental patterning in the olfactory epithelium, as manifested by the zonal expression of olfactory receptor genes remains mysterious for decades. Here, we describe genetic and epigenetic factors regulating zonal olfactory receptor expression, and we seek to uncover regulatory principles that are applicable to other systems undergoing developmental patterning.

PI_NAMEs: LOMVARDAS, STAVROS  (contact)

PROGRAM_OFFICER_NAME: SULLIVAN, SUSAN L

PROJECT_TERMS: Adaptor Signaling Protein;Affect;Alleles;Architecture;Biological;Cleavage Under Targets and Release Using Nuclease;Data;Deposition;Development;developmental disease;Developmental Process;DNA Modification Process;Down-Regulation;Ectopic Expression;Enhancers;epigenetic memory;Epigenetic Process;experimental study;Family;Feedback;Gene Cluster;Gene Expression;Gene Family;Genes;Genetic;Genetic Transcription;Genomics;Goals;Greek;histone modification;imprint;In Situ;Individual;insight;Island;Knockout Mice;Location;Mediating;Molecular;nerve stem cell;Neuronal Differentiation;NFIA gene;NFIB gene;NFIX gene;novel;Nuclear;nuclear factor 1;Olfactory Epithelium;olfactory receptor;olfactory sensory neurons;Pattern;prevent;Process;progenitor;programs;promoter;Proteins;receptor expression;Receptor Gene;recruit;Regulation;Regulatory Element;Repression;Role;Signal Transduction;Sorting;Specific qualifier value;stem cells;Stochastic Processes;System;Transcription Coactivator;transcription factor;Transcriptional Activation;Transgenic Mice

PROJECT_TITLE: Principles of zonal olfactory receptor gene expression


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Aging;Bioengineering;Biomedical Imaging;Clinical Research;Osteoporosis;Rare Diseases;Women's Health Research

ORG_CITY: LA JOLLA

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: 8. Project Narrative The goal of this project is to develop and combine novel 3D UTE MRI techniques to evaluate cortical and trabecular bone offering full insight into bone characterization and correlation with function. In the cadaveric human bone studies the 3D UTE MRI techniques will be compared with reference techniques including µCT, histomorphometry, Raman spectroscopy, and biomechanical testing as reference standard. In the human studies the 3D UTE MRI techniques will be applied to elderly women (age > 70y) with (n = 30) and without (n=30) osteoporosis, with osteopenia (n = 30) and with ROD (n = 30), as well as a group of young healthy women (age < 40y, n = 30), to compare the 3D UTE biomarkers in the different groups and correlate the results with BMD, biochemical markers and fracture history.

PI_NAMEs: DU, JIANG  (contact)

PROGRAM_OFFICER_NAME: NICKS, KRISTY

PROJECT_TERMS: 3-Dimensional;accurate diagnosis;Achievement;Affect;Age;age group;Aging;American;Award;Binding;Biochemical Markers;Biological Markers;biomechanical test;Biomechanics;Body mass index;bone;Bone Density;bone imaging;Cadaver;chemical reduction;Chemicals;Clinical;clinical practice;cohort;Collagen;Cone;Control Groups;cortical bone;cost;crosslink;crystallinity;Development;Diagnosis;Diagnostic;Disease;Dual-Energy X-Ray Absorptiometry;Elasticity;Elderly woman;Ethnic Origin;Etiology;Evaluation;Failure;Femur;femur head;Fracture;Goals;Head and neck structure;Human;Image;Individual;insight;Magnetic Resonance Imaging;Maps;Measurement;Measures;mechanical properties;Metabolic Bone Diseases;millisecond;mineralization;Minerals;Modality;Modeling;Morphologic artifacts;novel;older women;Osteomalacia;Osteopenia;Osteoporosis;Participant;Patients;Physiologic pulse;Porosity;Predisposition;Property;Protons;Raman Spectrum Analysis;Recording of previous events;Recovery;Reference Standards;Relaxation;Renal Osteodystrophy;research clinical testing;Roentgen Rays;Signal Transduction;Specimen;substantia spongiosa;Techniques;Testing;Time;Validation;Water;Woman;Work;World Health Organization

PROJECT_TITLE: Ultrashort Echo Time (UTE) Magnetic Resonance Imaging of Bone

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Cannabinoid Research;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Opioid Misuse and Addiction;Opioids;Substance Misuse;Therapeutic Cannabinoid Research

ORG_DEPT: PHARMACOLOGY

PHR: PROJECT NARRATIVE This research project will provide important public health and safety information regarding the effects of cannabis in individuals with opioid use disorder. This project will examine the manner in which both acute and repeated doses of vaporized cannabis alter the expression of opioid withdrawal, modify the abuse potential of opioids, and affect the physiological safety profile of opioids; cannabis tolerance and withdrawal will also be assessed.

PI_NAMEs: BABALONIS, SHANNA  (contact)

PROGRAM_OFFICER_NAME: WANG, JIA BEI

PROJECT_TERMS: abuse liability;Acute;Address;Affect;Agonist;Anxiety;Benefits and Risks;Buprenorphine;Cannabinoids;Cannabis;cannabis administration;Cannabis policy;cannabis withdrawal;clinical practice;Clinical Research;Complement;Data;design;Dose;Double-Blind Method;Dronabinol;drug misuse;effective therapy;Enrollment;epidemiology study;FDA approved;high risk population;illicit drug use;Impairment;Individual;Inhalation;innovation;Inpatients;Life;Maintenance;Marijuana;marijuana use;Measures;Medical Marijuana;medication for opioid use disorder;Methadone;Modeling;mortality;Naltrexone;Opiate Addiction;Opioid;opioid abuse;opioid epidemic;opioid misuse;opioid mortality;opioid overdose;opioid use;opioid use disorder;opioid withdrawal;Oral;Oral Administration;Outcome;overdose death;Panic;Participant;Patients;Persons;Pharmaceutical Preparations;Pharmacodynamics;Physical Dependence;Physiological;Placebo Control;placebo group;Placebos;Population;Public Advocacies;Public Health;Qualifying;Randomized;Reporting;Research;Research Project Grants;respiratory;Route;Safety;Sampling;Severities;sleep quality;Statutes and Laws;Study Subject;Tachycardia;Testing;Therapeutic Effect;Time;US State;Ventilatory Depression;Withdrawal

PROJECT_TITLE: Cannabis Modulation of Outcomes Related to Opioid Use Disorder: Opioid Withdrawal, Opioid Abuse Potential and Opioid Safety

STUDY_SECTION: ARM

STUDY_SECTION_NAME: Addiction Risks and Mechanisms Study Section[ARM]


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Hepatitis;Hepatitis - B;Infectious Diseases;Liver Disease

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Despite the availability of an effective vaccine, epidemiologic data estimates about 2 billion people in the world are infected with hepatitis B virus (HBV) and approximately 350 million people are chronic HBV carriers and at high risk for the development of hepatitis, cirrhosis and hepatocellular carcinoma (HCC). Current treatment options suppress the virus but do not cure, requiring costly lifetime therapy. The goal of this proposal is to validate our novel class of highly potent Capsid Assembly Modulators (CAM), which, when combined with other modalities (e.g., nucleoside analogs), could provide preclinical “proof of concept” towards a novel therapeutic strategy to eliminate HBV and with potential to reduce treatment duration and eliminate progression to HCC.

PI_NAMEs: SCHINAZI, RAYMOND FELIX (contact)

PROGRAM_OFFICER_NAME: FLORES, AMANDA CHRISTINE

PROJECT_TERMS: Acceleration;anti-hepatitis B;anti-viral efficacy;Antigens;Area;Binding;Biochemical;Biological Assay;Capsid;Cell Line;Cells;Chemicals;Chronic Hepatitis B;Circular DNA;Cirrhosis;Clinical Research;Coin;Complex;Core Protein;cytotoxicity;Data;Development;dimer;DNA biosynthesis;drug candidate;Drug Kinetics;drug metabolism;epidemiologic data;FDA approved;Genetic Transcription;Goals;Hepatitis;Hepatitis B e Antigens;Hepatitis B Infection;Hepatitis B Surface Antigens;Hepatitis B Virus;Hepatocyte;high risk;Homo;Human;Immunofluorescence Immunologic;In Vitro;in vivo;in vivo evaluation;Infection;inhibitor;innovation;Kinetics;Lead;life time cost;light scattering;Link;Modality;Monitor;monomer;Morphology;mouse model;mutant;Negative Staining;novel;novel therapeutic intervention;nucleoside analog;particle;Persons;pgRNA;Pharmaceutical Preparations;Phase I Clinical Trials;Phase Ib Clinical Trial;Population;pre-clinical;preclinical study;prevent;Primary carcinoma of the liver cells;programs;Proliferating;Property;Proteins;Regimen;Resistance;Resistance profile;Safety;scale up;Series;Site;Structure;Therapeutic;Time;Toxic effect;Transmission Electron Microscopy;treatment duration;United States National Institutes of Health;Vaccines;Viral;viral DNA;Viral Physiology;Virus;virus core;Virus Diseases;Virus Replication;Work

PROJECT_TITLE: HBV Capsid Effectors

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AIDC-B(82)]


NIH_SPENDING_CATS: Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Social Determinants of Health

ORG_CITY: MADISON

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Project Narrative This application is to support a summer research training experience for undergraduate students who are underrepresented in the environmental health sciences. Underrepresented includes students from diverse racial or ethnic backgrounds, economically disadvantaged communities, that are disabled, or are first in their family to attend college. Goals of this program are to increase the diversity of the Environmental Health Sciences workforce through hands on laboratory and training in foundations of toxicology, research and career development.

PI_NAMEs: BRADFIELD, CHRISTOPHER A (contact);RONNEKLEIV-KELLY, SEAN M.

PROGRAM_OFFICER_NAME: HUMBLE, MICHAEL C

PROJECT_TERMS: Acceleration;Achievement;Area;Biological Sciences;career;Career Choice;career development;Chemicals;Cities;college;Communication;Communities;Community Health;Computer software;Coupled;Critical Thinking;Data;Data Science;Dedications;design;Development;disabled;disadvantaged student;disparity reduction;diversity and equity;economic disparity;Education;Educational Curriculum;Elements;Environment;Environmental Health;Environmental Science;environmental toxicology;Epidemiology;Ethnic Origin;Event;experience;Exposure to;Face;Family;Foundations;Future;Genetic;Goals;Government;Graduate Education;graduate student;Group Structure;Health;health data;health equity;health science research;Human;Industry;Interdisciplinary Study;interest;Laboratories;laboratory experience;Laboratory Research;Learning;Life;Mentors;Mentorship;Minority;Modernization;Molecular;Molecular Toxicology;National Institute of Environmental Health Sciences;neighborhood disadvantage;next generation;Outcome;peer coaching;Phase;postgraduate education;Preparation;prevent;programs;Race;racial diversity;racial minority;recruit;Regulation;Research;research and development;Research Personnel;Research Project Grants;Research Training;Rewards;Risk Assessment;Science;Scientist;skills;social;social influence;socioeconomic diversity;Students;success;summer program;summer research;Talents;Technology;tool;Toxic effect;Toxicology;Training;Training Programs;undergraduate student;Underrepresented Minority;underrepresented minority student;Underrepresented Students;United States;Universities;Wisconsin;Work;Writing

PROJECT_TITLE: Molecular and Environmental Toxicology Summer Research Opportunities Program (MET-SROP)


NIH_SPENDING_CATS: Digestive Diseases;Infectious Diseases

ORG_CITY: Newark

ORG_DEPT: PATHOLOGY

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: PROJECT NARRATIVE. The proposed research is relevant to public health because it will elucidate the fundamental biological processes by which the immune system contributes to maintenance of the mucosal barrier. This essential knowledge is required to understand mucosal surveillance during intestinal homeostasis and in response to pathogen infection. This work will therefore directly support the overall NIH mission of developing knowledge that will help reduce the burden of human disease and promote the NIAID goal of preventing infectious and immunologic diseases.

PI_NAMEs: BERGSBAKEN, TESSA  (contact);EDELBLUM, KAREN LEIGH

PROGRAM_OFFICER_NAME: HUDSPETH, KELLY

PROJECT_TERMS: Address;Antigens;Autoimmunity;Behavior;Binding;Biological Process;cadherin 10;Carcinoma;CD8B1 gene;Celiac Disease;Cell Line;Cell Physiology;Cells;Colorectal;combinatorial;Communicable Diseases;Cues;cytokine;Cytoplasmic Granules;dietary;E-Cadherin;enteric infection;enteric pathogen;Epithelial Cells;Epithelium;Event;Exhibits;Exocytosis;experimental study;Gene Expression;Goals;Granzyme;Homeostasis;human disease;Immune system;Immune System Diseases;Immunity;improved outcome;in vivo;Infection;Infection Control;Inflammatory Bowel Diseases;insight;Integrins;intestinal barrier;intestinal epithelium;intestinal homeostasis;Intestines;intraepithelial;Invaded;Investigation;Knowledge;Ligation;Lymphocyte;Lymphocyte Activation;Lymphocyte Count;Lymphocyte Function;Maintenance;Mediating;Memory;Microbe;microbial;microorganism;migration;Mission;Modeling;Molecular;Motility;Mucous Membrane;National Institute of Allergy and Infectious Disease;novel;pathogen;Pathogenicity;Play;Population;prevent;Public Health;recruit;Regulation;Research;response;Rest;Role;Sentinel;Signal Pathway;Signal Transduction;Site;T-Lymphocyte;Therapeutic;Tissues;Toxin;Tumor-Infiltrating Lymphocytes;United States National Institutes of Health;Virus Diseases;Work

PROJECT_TITLE: CD103 engagement regulates intestinal IEL effector function

STUDY_SECTION: IHD

STUDY_SECTION_NAME: Immunity and Host Defense Study Section[IHD]


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_CITY: Princeton

ORG_NAME: PRINCETON UNIVERSITY

PHR: Narrative To implant into the mother’s womb and give rise to a viable fetus, the preimplantation mammalian embryo must produce the right number of embryonic and extraembryonic cell types. Using the early mouse embryo as a powerful and accessible model, we will investigate the molecular and cellular mechanisms which ensure that developmental programs are executed in a timely and spatially ordered manner and that an adequate number of cells are generated to build an embryo. Our work will reveal fundamental insights into the regulatory principles of early mammalian development and serve as a basis for understanding how errors in these processes lead to developmental disorders or pregnancy loss.

PI_NAMEs: POSFAI, ESZTER  (contact)

PROGRAM_OFFICER_NAME: MUKHOPADHYAY, MAHUA

PROJECT_TERMS: 3-Dimensional;Address;analysis pipeline;ATAC-seq;Automobile Driving;Binding;Biological Models;Biosensor;blastocyst;Caenorhabditis elegans;Capsicum;Cell Communication;Cell Cycle Progression;Cell Differentiation process;cell fate specification;cell type;Cells;Characteristics;Chromatin;Cleavage Under Targets and Release Using Nuclease;Color;Complex;Cues;Data;Data Set;Development;developmental disease;Developmental Process;Drosophila genus;Educational process of instructing;Embryo;embryo cell;Embryonic Development;Endoderm;Endoderm Cell;Ensure;Environment;Epiblast;fascinate;Fetus;Fibroblast Growth Factor;flexibility;Gene Expression;Gene Expression Profile;Genetic;Genetic study;Genetic Transcription;Genome engineering;genome-wide;Genomic approach;Genomics;Heterogeneity;Human;Image;Image Analysis;image processing;imaging approach;Implant;Individual;Inherited;Inner Cell Mass;insight;intercellular communication;Lead;Mammals;mathematical model;model organism;Modeling;Molecular;Morphology;Mothers;Mus;Nature;Neighborhoods;novel;Nucleic Acid Regulatory Sequences;Organism;Outcome;Pattern;pharmacologic;Population;Positioning Attribute;Pregnancy loss;preimplantation;Process;programs;Recording of previous events;Reporter;Reproducibility;Resolution;segregation;Shapes;Signal Transduction;Sodium Chloride;Sorting;Source;Specific qualifier value;Statistical Data Interpretation;Stereotyping;Structure;Techniques;Technology;temporal measurement;Testing;Time;tool;transcription factor;Uterus;Variant;Visualization;Work

PROJECT_TITLE: Mechanisms of epiblast and primitive endoderm segregation


ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: PROJECT NARRATIVE Following epilepsy surgery, roughly half of patients will continue to have seizures, and 70-90% will remain on anti-seizure medications. Using data recorded from the brains of epilepsy patients, we propose to develop and validate computerized tools to accurately and objectively identify epileptic brain regions. This will improve surgical decision making, make epilepsy surgery available to more patients, and ultimately improve the lives of patients with the most severe types of epilepsy.

PI_NAMEs: LOPOUR, BETH ANN (contact)

PROGRAM_OFFICER_NAME: WHITTEMORE, VICKY R

PROJECT_TERMS: Accounting;anti-epileptic agents;Anticonvulsants;Area;Biological Markers;Blinded;Brain;brain electrical activity;Brain imaging;Brain region;brain tissue;Characteristics;childhood epilepsy;Classification;Clinical;clinical implementation;Clinical Trials;Complex;computerized tools;Coupled;Data;Decision Making;density;Detection;Electrocorticogram;Electrodes;Electroencephalography;Electrophysiology (science);Epilepsy;Event;Excision;Failure;Freedom;Frequencies;Goals;High Frequency Oscillation;high standard;Implant;Implanted Electrodes;improved;improved outcome;Individual;Intuition;Knowledge;Measurement;Measures;Methodology;Methods;minimally invasive;Modeling;Monitor;Morphology;neurotransmission;novel;Operative Surgical Procedures;Outcome;Pathologic;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;Physiological;Postoperative Period;Procedures;prospective;Prospective Studies;Quality of life;Recommendation;Research;Resected;risk minimization;Seizures;Sensitivity and Specificity;Signal Transduction;simulation;Specificity;Surface;Surgeon;Surgical Management;Techniques;Testing;Tissues;Vision;Work

PROJECT_TITLE: Seizure localization for epilepsy surgery using high frequency electrophysiological markers

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


NIH_SPENDING_CATS: Bioengineering;Cancer;Nanotechnology;Wound Healing and Care

ORG_CITY: KENT

ORG_DEPT: CHEMISTRY

ORG_NAME: KENT STATE UNIVERSITY

PHR: Project Narrative This project will test strategies to modulate cell migrations using mechanical actuation that is responsive to chemical (pH and oligonucleotides) environment and light of different colors. The project will also design a force gauge to measure mechanical force involved in the cell migration processes. The knowledge obtained will help to heal skin wounds and fight various diseases associated with abnormal cell migrations.

PI_NAMEs: MAO, HANBIN  (contact)

PROGRAM_OFFICER_NAME: JOHNSON, ERIC MICHAEL

PROJECT_TERMS: 3-Dimensional;Abnormal Cell;Acidity;Acids;Actins;Address;Affinity;alkalinity;Autoimmune Diseases;azobenzene;Binding;Biological Assay;Biological Process;biomaterial compatibility;Blood Vessels;cancer cell;Cell Communication;Cell membrane;cell motility;Cell Physiology;Cells;Chemicals;Color;Competitive Binding;Complementary DNA;Cues;Cytoskeletal Proteins;density;design;Digestion;Disease;Distal;DNA;Dyes;Elements;Embryonic Development;Ensure;Environment;Enzymes;Equilibrium;experience;Extracellular Matrix;fabrication;Fiber;fighting;Fluorescence Resonance Energy Transfer;fluorophore;Focal Adhesions;Genetic;Growth;Hela Cells;Human;Image;Immune response;In Situ;innovation;Integrin Binding;Integrins;invention;Isomerism;Knowledge;laser tweezer;Lateral;Laws;Length;Ligand Binding;Ligands;Light;Linker DNA;Macrophage;Measurement;Measures;mechanical force;mechanical properties;Mechanics;mechanotransduction;Membrane;Methods;migration;Migration Assay;Monitor;Morphology;Motion;nano-objects;nanoassembly;nanodevice;nanometer;nanoscale;Nanostructures;Neoplasm Metastasis;Oligonucleotides;optic tweezer;Organism;Pathway interactions;Penetration;Photons;photostimulus;Play;Process;receptor;Reporting;Role;self assembly;side effect;Signal Transduction;single molecule;Single-Stranded DNA;Skin;skin wound;Skin wound healing;Specificity;Structure;Surface;Testing;three dimensional structure;tool;Topical application;tumor;With laterality;wound healing

PROJECT_TITLE: Mechanical Modulation of Cell Migrations by DNA Nanoassemblies

STUDY_SECTION: NANO

STUDY_SECTION_NAME: Nanotechnology Study Section[NANO]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Prostate Cancer;Urologic Diseases

ORG_CITY: Chicago

ORG_NAME: NORTHWESTERN UNIVERSITY

PHR: Narrative: To make breakthroughs against lethal metastatic cancers, we need to identify the molecular mechanisms that allow cancer cells to escape existing line of treatments. In this project, we will develop an automated blood-to-barcode chip that accelerates CRISPR-based discovery efforts to identify druggable targets. Using systematic target validation and testing of drug-like molecules for establishing clinical utility, we provide a framework to expedite the development of new line of effective treatments against metastatic cancer.

PI_NAMEs: KELLEY, SHANA O (contact)

PROGRAM_OFFICER_NAME: OSSANDON, MIGUEL

PROJECT_TERMS: Acceleration;Algorithms;Antimetastatic Agent;Automobile Driving;Bar Codes;Bioinformatics;Biological Assay;Biological Models;Biology;Blood;Blood Circulation;Blood specimen;Cancer Biology;cancer cell;Cancer Patient;Cancerous;Cause of Death;Cell Line;cell motility;Cell Separation;Cells;Cessation of life;Chemicals;Circulation;Clinical;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;Code;combat;Communities;comparative;Coupled;CRISPR screen;CRISPR-mediated transcriptional activation;Cues;design;Development;Disease;Disseminated Malignant Neoplasm;drug discovery;drug testing;drug-like compound;druggable target;effective therapy;enhancing factor;Exhibits;functional genomics;Gene Expression Profile;Gene Expression Profiling;Genes;Genetic;Genetic Drift;genetic information;Genetic study;genome-wide;Genomics;Goals;Guide RNA;Heterogeneity;Human;Human Biology;human disease;Human Genome;improved;In Vitro;in vivo;Individual;inhibitor;Invaded;Knock-out;knockout gene;Lead;lead candidate;Lesion;loss of function;Malignant neoplasm of prostate;Malignant Neoplasms;Mesenchymal;Metastatic Prostate Cancer;Microfluidic Microchips;Microfluidics;Migration Assay;Modeling;Molecular;multidisciplinary;Mus;Mutation;Neoplasm Circulating Cells;Neoplasm Metastasis;neoplastic cell;new technology;new therapeutic target;next generation;next generation sequencing;novel;novel therapeutics;overexpression;Pathway interactions;Patient-Focused Outcomes;Performance;pharmacologic;Phenotype;Population;prevent;Primary Neoplasm;Process;Production;programs;prostate cancer cell;prostate cancer cell line;prostate cancer model;Protein Secretion;Proteins;Proteomics;rare cancer;Reporting;Reproducibility;Research Personnel;Resistance;Role;Route;Sampling;scale up;screening;Series;Signal Transduction;Site;Solid Neoplasm;Specimen;System;targeted treatment;Technology;Testing;Therapeutic;Therapeutic Agents;therapeutic target;Tissue-Specific Gene Expression;transcriptomics;Travel;Triage;tumor;tumor heterogeneity;tumor progression;Tumor Promotion;tumor xenograft;Validation;Whole Blood;whole genome;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Development of Next-Generation Blood-to-barcode (B2B) chip for In Vivo CRISPR-Based Discovery of Metastasis Regulators

STUDY_SECTION_NAME: Instrumentation and Systems Development Study Section[ISD]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: ATHENS

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF GEORGIA

PHR: PROJECT NARRATIVE Calcium signaling is essential for pathogenesis. The studies proposed will use as a model, the unicellular pathogen Toxoplasma gondii, which infects almost one third of the world population. Our studies will highlight fundamental concepts on the mechanism by which eukaryotic pathogens may cause disease.

PI_NAMEs: MORENO, SILVIA N (contact)

PROGRAM_OFFICER_NAME: MCGUGAN, GLEN C

PROJECT_TERMS: Address;Affinity;Animals;Antiparasitic Agents;Bacteria;Bacterial Adhesins;Biochemical;Biological;Biological Process;Biology;Calcium;Calcium Channel;Calcium Signaling;Candidate Disease Gene;Cell Differentiation process;Cell membrane;Cell Physiology;Cells;Characteristics;Clinical;Collaborations;Complex;Cryptosporidiosis;Cytosol;Data;Defect;Dihydropyridines;Disease;Drug Targeting;Electrophysiology (science);Elements;Endoplasmic Reticulum;Environment;Event;extracellular;Fertilization;Fetus;fungus;Gene Expression;Genes;Genetic;Growth;HIV;Image;Immunocompromised Host;Individual;Infection;insight;Invaded;Ion Channel;Ions;Knowledge;Life;Lipid Bilayers;Lytic Phase;Malaria;Mammalian Cell;member;Modeling;Molecular;molecular sequence database;Morbidity - disease rate;mortality;Motility;Muscle Contraction;Names;Neurotransmitters;Nifedipine;novel;novel therapeutics;opportunistic pathogen;organ transplant recipient;Parasites;Parasitology;pathogen;Pathogenesis;Pathogenicity;Pathology;Pathway interactions;Persons;Physiological;Plants;Play;Population;Proteins;Proteomics;Publishing;receptor;Regulation;Research;Role;Rupture;Signal Pathway;Signal Transduction;Source;System;Techniques;Therapeutic;therapeutic target;Tissues;tool;Toxoplasma gondii;Toxoplasmosis;Training;trait;Travel;Virulence;voltage;Work

PROJECT_TITLE: Divergent Calcium Channels of the Apicomplexan parasite Toxoplasma gondii

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IIDA-F(02)]


NIH_SPENDING_CATS: Infectious Diseases;Microbiome;Prevention;Sexually Transmitted Infections;Topical Microbicides;Women's Health Research

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Bacterial vaginosis (BV) is characterized by low levels of protective vaginal bacteria (Lactobacilli), is associated with serious sequelae, such as HIV and STI acquisition, and is asymptomatic in 55% of women. It is unknown if risks for adverse outcomes differ between women with asymptomatic (aBV) versus symptomatic (sBV), yet current guidelines only indicate antibiotic treatment for symptomatic women, leaving asymptomatic women potentially at risk. We will leverage a large database of existing data to determine whether behavioral factors and the vaginal microenvironment differ between aBV and sBV, generating data which will inform a better understanding of the entity of aBV, new studies of associations between aBV, HIV, STIs, and, in the long term, studies of aBV treatment in order to improve reproductive health.

PI_NAMEs: TUDDENHAM, SUSAN ANNE (contact)

PROGRAM_OFFICER_NAME: CHUANG, ELEANORE JENNIFER

PROJECT_TERMS: 16S ribosomal RNA sequencing;adverse outcome;Affect;Age;American;Anaerobic Bacteria;Antibiotic Therapy;Area;Atopobium vaginae;Automobile Driving;Bacteria;Bacterial Vaginosis;Behavioral;biobehavior;Biogenic Amines;Biological Response Modifier Therapy;Black race;career development;cervicovaginal;Chlamydia;Clinical Research;Clinical Treatment;Cohort Studies;condoms;cytokine;Data;Data Sources;Databases;design;Development;dysbiosis;effective therapy;Epidemiology;epidemiology study;Feminine;Funding;Future;Grant;Guidelines;HIV;HIV risk;HIV-1;hormonal contraception;Hygiene;IL6 gene;IL8 gene;Immunologic Factors;Immunologics;improved;infection risk;Inflammation;Inflammation Mediators;Inflammatory;Interferon Type II;Interleukin-1 beta;Isomerism;K-Series Research Career Programs;Lactic acid;Lactobacillus;Lavage;Lead;Longitudinal Studies;Mediating;metabolome;metabolomics;Methods;microbiota;National Institute of Allergy and Infectious Disease;NIH Program Announcements;novel;Output;Pathogenesis;Patients;perceived stress;Perception;Pilot Projects;Predisposition;prevent;programs;Publishing;randomized trial;Recommendation;Recurrence;reproductive;Reproductive Health;Research;Research Project Grants;response;Risk;rRNA Genes;Sampling;secondary analysis;Sexually Transmitted Diseases;Smoking;symptom treatment;symptomatology;Symptoms;Taxonomy;Testing;Uncertainty;United States National Institutes of Health;Vagina;vaginal microbiome;vaginal microbiota;Woman;Women's Health

PROJECT_TITLE: The vaginal microenvironment in asymptomatic versus symptomatic bacterial vaginosis

STUDY_SECTION: PRID

STUDY_SECTION_NAME: Population based Research in Infectious Disease Study Section[PRID]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Cancer;Immunotherapy

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: PROJECT NARATIVE Our proposal aims to analyze the mechanisms by which immune therapies for cancer (checkpoint inhibitors) cause thyroid disease. Our focus is on the intrinsic functions of the checkpoint molecule, PD-L1, in the thyroid, and how blocking it causes thyroid cell stress and thyroiditis. These studies will identify the mechanisms by which checkpoint inhibitors cause thyroiditis and will hopefully help in the development of novel therapies.

PI_NAMEs: STEFAN-LIFSHITZ, MIHAELA ;TOMER, YARON  (contact)

PROGRAM_OFFICER_NAME: LIU, YIN

PROJECT_TERMS: Acceleration;Adrenergic beta-Antagonists;Adverse event;Affect;anti-PD-L1;Apoptosis;Autoimmunity;Autophagocytosis;Biological Assay;Biotin;cancer cell;cancer therapy;Cell Line;Cell Survival;Cells;Cellular Stress;Cessation of life;checkpoint therapy;cytokine;design;Development;Endocrine;endoplasmic reticulum stress;experience;Exposure to;Functional disorder;Genes;Goals;Human;Hypothyroidism;Immune;immune activation;Immune checkpoint inhibitor;Immune Evasion;immune-related adverse events;Immunological Models;immunoregulation;Immunotherapy;Induction of Apoptosis;Inflammation;Inflammatory;Interferon Type II;Interferons;Ligands;Ligation;Light;Malignant Neoplasms;Mediating;Mediator;Mitochondria;Molecular;Monoclonal Antibodies;mouse model;multidisciplinary;Mus;mutant;new therapeutic target;novel therapeutics;Organ;overexpression;Pathway interactions;Patients;Phase;Predisposition;prevent;programmed cell death ligand 1;programmed cell death protein 1;protective effect;Proteins;receptor;response;restoration;Role;Signal Transduction;Sirolimus;Stress;T-Cell Activation;T-Lymphocyte;Testing;therapeutically effective;Thyroid Diseases;Thyroid Gland;Thyroid Hormones;Thyroiditis;Tissues;Toxic effect;Translating;Up-Regulation

PROJECT_TITLE: Endocrine tissue molecular pathways dysregulated by immune checkpoint inhibitors causing ICI-triggered adverse events

STUDY_SECTION: CSME

STUDY_SECTION_NAME: Cell Signaling and Molecular Endocrinology Study Section[CSME]