ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Childhood Injury;Clinical Research;Data Science;Emergency Care;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Patient Safety;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Suicide;Suicide Prevention

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PI_NAMEs: LIU, RICHARD T (contact)

PROGRAM_OFFICER_NAME: O'CONNOR, STEPHEN

PROJECT_TERMS: Accident and Emergency department;Acute;acute care;Address;Affect;Age;algorithm training;Algorithms;Assessment tool;Behavior;Black race;Black, Indigenous, People of Color;Caring;Childhood;Classification;Clinical;clinical care;Common Data Element;computerized;Data;Development;Disparity population;Electronic Health Record;Emergency department visit;ethnic minority population;Ethnic Origin;Evaluation;Funding;Future;Goals;health disparity;health inequalities;Hospitalization;implementation evaluation;improved;Income;indexing;Individual;innovation;inpatient service;Inpatients;Intervention;Latinx;Learning;Linguistics;Link;Machine Learning;machine learning algorithm;Measurement;Mental Health;Methods;mindfulness;Minority;minority children;Minority Groups;minority patient;Modeling;National Institute of Mental Health;Natural Language Processing;Neighborhoods;patient population;Patient Self-Report;Patients;pediatric emergency;peer;Performance;Population;Population Heterogeneity;portability;Poverty;prediction algorithm;predictive tools;Predictive Value;Prevention;prospective;Provider;psychiatric inpatient;Psychopathology;public health emergency;Race;racial minority population;Reduce health disparities;Research;Resources;Risk;Risk Factors;risk prediction;Sampling;screening;Site;social health determinants;Source;standard care;suicidal morbidity;suicidal risk;Suicide;Suicide attempt;Suicide prevention;suicide rate;Testing;tool;Training;trend;Underrepresented Populations;Underserved Population;United States National Institutes of Health;Validation;Visit;Youth

PROJECT_TITLE: Improving Suicide Risk Prediction in Racial, Ethnic, and Linguistic Minority Youth


ADMINISTERING_IC: AI

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Emerging Infectious Diseases;Genetics;Hematology;Human Genome;Infectious Diseases;Prevention;Rare Diseases;Sepsis

ORG_CITY: TORRANCE

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER

ORG_STATE: CA

PHR: PROJECT NARRATIVE This research is highly relevant to public health because hematogenously disseminated candidiasis is a frequent hospital acquired infection that results in a high degree of mortality in adults and neonates, even with currently available treatment. Discovering C. albicans and host immune signatures associated with lethality and persistence during candidemia holds promise to provide new insight into the pathogenesis of disseminated candidiasis. Furthermore, this information may be used to develop new diagnostic or therapeutic strategies against this frequently fatal disease.

PI_NAMEs: FILLER, SCOTT G (contact)

PROJECT_TERMS: Address;Adult;Affect;Aneuploidy;anti-fungal agents;Antifungal Therapy;biobank;Bioinformatics;Blood;Blood Circulation;Candida;Candida albicans;Candidate Disease Gene;candidemia;Cell Differentiation process;Cell Physiology;Characteristics;Chromatin;Chromosomes;Clinical;cohort;Computer Models;cytokine;Data;Diagnosis;Disease;Disseminated candidiasis;DNA Sequence Rearrangement;Endothelial Cells;Epigenetic Process;epigenomics;Filament;Fungal Drug Resistance;fungus;Gene Silencing;Genetic;Genetic Polymorphism;Genetic Variation;genome sequencing;genome-wide;Genomics;Genotype;Growth;Hematogenous;Hospitalization;Host Defense Mechanism;Human;IL12B gene;IL8RA gene;Immune;immune activation;Immune response;Immune signaling;Immune system;Individual;Infection;insight;Interleukin-10;Invaded;Knowledge;Life;Link;Loss of Heterozygosity;Medical Economics;Microbial Biofilms;Modeling;Molecular;Monitor;mortality;mouse model;Mucous Membrane;Mus;Mutation;neonate;Nosocomial Infections;novel;novel diagnostics;novel strategies;novel therapeutic intervention;oropharyngeal thrush;Outcome;pathogen;Pathogenesis;Patient Selection;Patient-Focused Outcomes;Patients;Pattern;Phagocytosis;Phenotype;predictive modeling;Predisposition;prevent;Production;Public Health;Research;response;Risk;Risk Factors;Role;Sampling;Sepsis;Signal Pathway;Signal Transduction;socioeconomics;STAT protein;Stream;System;Testing;TLR1 gene;transcription factor;Transcriptional Activation;transcriptome sequencing;transcriptomics;treatment response;Variant;virtual;Virulence;Virulence Factors;Whole Blood;whole genome

PROJECT_TITLE: Epigenomic Mechanisms & STAT Networks in Persistent CA Candidemia


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Aging;Arthritis;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Urologic Diseases

ORG_CITY: EVANSTON

ORG_NAME: ENDEAVOR HEALTH CLINICAL OPERATIONS

ORG_STATE: IL

PHR: NARRATIVE Benign prostatic hyperplasia (BPH) and associated lower urinary tract symptoms (LUTS) are a major cause of morbidity in aging men. There are limited medical options to treat patients with BPH/LUTS and no new medical treatments have been developed in nearly 30 years. This project will test the efficacy and consequences of TNF- antagonists in BPH/LUTS patients with large prostate volumes.

PI_NAMEs: GLASER, ALEXANDER PAUL;HAYWARD, SIMON W (contact)

PROGRAM_OFFICER_NAME: KIRKALI, ZIYA

PROJECT_TERMS: 5 Alpha-Reductase Inhibitor;adalimumab;Adrenergic alpha-Antagonists;Affect;Aging;antagonist;Antigen Presentation;Apoptosis;arm;Autoimmune;Benign Prostatic Hypertrophy;Blood;Cell Proliferation;Cells;Chronic;Clinical;Collection;comorbidity;Data;derepression;Development;Diabetes Mellitus;Diagnosis;Disease;Double-Blind Method;Drug usage;economic cost;Effectiveness;efficacy evaluation;efficacy testing;Environment;Failure;Flow Cytometry;Future;Genes;genetic predictors;genetic risk factor;genetic variant;Genomics;Gland;Health Expenditures;Human;Humira;Immune;Immunohistochemistry;immunoregulation;improved;Incidence;individual response;Inflammation;Inflammatory;intravesical;Link;lower urinary tract symptoms;Measures;Medical;men;Methotrexate;Morbidity - disease rate;mouse model;Muscle relaxation phase;Muscle Tonus;novel strategies;Obesity;Operative Surgical Procedures;Pathogenesis;Pathway Analysis;Pathway interactions;Patient Outcomes Assessments;patient population;patient stratification;Patients;pilot trial;Placebos;Population;Predisposition;Prevalence;Prevention;Procedures;Productivity;Proliferating;Prophylactic treatment;Prostate;Prostatic;Prostatic hypertrophy;Psoriatic Arthritis;Randomized;randomized placebo controlled trial;response;Rheumatoid Arthritis;Schedule;Severities;Signal Transduction;single-cell RNA sequencing;Symptoms;Testing;Therapeutic;Time;Tissues;TNF gene;transcriptome sequencing;Treatment outcome;Tumor Necrosis Factor Receptor;United States;Work

PROJECT_TITLE: Effects of TNF Blockade on Human BPH/LUTS

STUDY_SECTION: KUFD

STUDY_SECTION_NAME: Kidney and Urological Systems Function and Dysfunction Study Section[KUFD]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Dental, Oral, and Craniofacial Disease;Electronic Nicotine Delivery Systems;Genetics;Human Genome;Prevention;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: Los Angeles

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Public Health Relevance Statement: Science-based evaluation of the safety of electronic cigarettes (e-cigs) and comprehensive risk-benefit analysis of vaping vs. smoking are urgently needed to inform the FDA’s regulation of tobacco products as well as advise the general public on the health consequences of e-cig use relative to cigarette smoking. This project will make an important scientific contribution to the fields of tobacco research, regulatory science, and public health by identifying molecular changes linked to risk of disease in cells and tissues of healthy adults who are regular users of e-cigs, cigarette smokers, or users of both products (dual users). Our research findings will be translated to lay messages, which can help educate the general public of the ‘pros’ and ‘cons’ of e-cig use relative to smoking.

PI_NAMEs: BESARATINIA, AHMAD  (contact)

PROGRAM_OFFICER_NAME: CHEN, ZHONG

PROJECT_TERMS: Aberrant DNA Methylation;Accounting;Adult;Affect;Benefits and Risks;Biochemical;Bioinformatics;Biological;Biological Assay;Biological Markers;Biological Specimen Banks;biomarker identification;bisulfite sequencing;Blood Cells;Carcinogens;cell type;Cells;Characteristics;Chemicals;Cigarette;cigarette smoke;Cigarette Smoker;cigarette smoking;combustible cigarette;comparison control;Computer Models;Data;Data Analyses;Data Set;demographics;Devices;Diet;differential expression;Disease;disorder risk;DNA Methylation;Dose;e-cigarette aerosols;Electronic cigarette;electronic cigarette use;electronic cigarette user;electronic liquid;Epigenetic Process;Evaluation;Funding;gene network;General Population;Generations;Genes;Genetic Transcription;genome-wide;Health;health assessment;Human;innovation;Laboratories;Leukocytes;Life Style;Link;Measurement;Measures;Methylation;methylome;model building;Modeling;Molecular;National Institute of Dental and Craniofacial Research;Nicotine;novel marker;novel strategies;Ontology;Oral;Pathway Analysis;Pathway interactions;patient population;Pattern;peripheral blood;Population;preservation;Process;Public Health;public health relevance;Research;Risk;RNA analysis;Safety;Science;segregation;Smoker;Smoking;Smoking History;Smoking Status;Source;Specimen;Study Subject;Tars;Tissues;Tobacco;tobacco products;tobacco regulation;Tobacco use;toxicant;transcriptome;transcriptome sequencing;transcriptomics;Translating;Validation;vaper;vaping;whole genome

PROJECT_TITLE: Differentiating the biological effects of vaping from smoking by analyzing the methylome and transcriptome

STUDY_SECTION: SIEE

STUDY_SECTION_NAME: Systemic Injury by Environmental Exposure[SIEE]


FUNDING_MECHANISM: RESEARCH CENTERS

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Mental Illness;Prevention;Serious Mental Illness;Suicide;Suicide Prevention

ORG_STATE: MA

PI_NAMEs: BENTLEY, KATE H. (contact)

PROJECT_TERMS: acceptability and feasibility;Acute;adaptive intervention;Admission activity;Affect;Agreement;Behavior;brief intervention;Caring;Cause of Death;Cellular Phone;clinical care;contextual factors;Coping Skills;Data;design;Development;Effectiveness;effectiveness testing;Environment;Evidence based intervention;Feedback;Feeling suicidal;follow-up;Future;handheld mobile device;help-seeking behavior;high risk;high risk population;Hospitalization;Human;improved;Individual;innovation;inpatient psychiatric treatment;inpatient service;Inpatients;interactive tool;Intervention;intervention effect;intervention refinement;Knowledge;Methods;mobile computing;Monitor;Outcome;Participant;Patient Self-Report;Patients;Persons;Physiology;Populations at Risk;post intervention;Precision therapeutics;Prevention;Protocols documentation;psychiatric inpatient;Psychiatric therapeutic procedure;Public Health;Randomized;randomized trial;Recommendation;Research;Risk Reduction;Safety;Social support;Source;suicidal;suicidal behavior;suicidal patient;suicidal risk;Suicide;Suicide prevention;Surveys;Technology;Telephone;Testing;Text Messaging;Time;tool;trial design;United States;Work

PROJECT_TITLE: Micro-randomized trial to assess brief, just-in-time interventions for reducing short-term suicide risk


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Nutrition;Obesity;Sleep Research

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Narrative Every day, humans must synchronize or entrain their internal body clock to the daily light-dark cycle for optimal physiological functioning. This proposal will uncover the influence of diet on the ability to entrain, circadian timing, and the consequences of an inability to entrain quickly. The findings from this project will not only be potentially paradigm shifting in the field of human circadian rhythms, but will also be critical to the cardiometabolic health and well-being of every individual.

PI_NAMEs: MCHILL, ANDREW WILLIAM (contact)

PROGRAM_OFFICER_NAME: BROWN, ALISON GWENDOLYN MARY

PROJECT_TERMS: Adolescent;American;Animal Model;Animals;Area;Attention;Behavior;Biological;Biological Clocks;Biological Process;Biomedical Research;Blood Vessels;Calories;cardiometabolism;Cardiovascular Diseases;Chronic Disease;circadian;Circadian desynchrony;Circadian Dysregulation;circadian pacemaker;Circadian Rhythms;cognitive function;Consumption;Darkness;Data;design;Diabetes Mellitus;Diet;dietary;Dietary Practices;disorder risk;Eating;Energy Metabolism;Environment;experience;Exposure to;Fat-Restricted Diet;Fatty acid glycerol esters;Foundations;Future;geographic difference;Goals;Health;High Fat Diet;Hour;Human;Impaired cognition;Impairment;improved;Individual;Inpatients;insight;insulin sensitivity;Jet Lag Syndrome;Laboratories;Learning;Length;Life Expectancy;Light;Melatonin;men;Metabolic syndrome;Mus;Myocardial Infarction;novel;obese patients;Obesity;Outcome;Outpatients;Performance;Personal Satisfaction;Persons;Phase;Physiological;Physiology;Process;programs;Public Health;Randomized;response;Rodent;Rodent Model;Schedule;Schools;Sleep;Sleep disturbances;sleep onset;social;Societies;Speed;Stimulus;Students;sudden cardiac death;System;Teenagers;Testing;theories;Time;Traffic accidents;Translating;Travel;western diet;Woman;Work;young adult

PROJECT_TITLE: Uncovering the Impact of Diet on the Human Circadian Timing System

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


NIH_SPENDING_CATS: Bioengineering;Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Dietary Supplements;Genetics;Pediatric

ORG_CITY: KANSAS CITY

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: PROJECT NARRATIVE Palatogenesis involves growth of bilateral embryonic palatal shelves, vertically next to the tongue, followed by elevation above the tongue in order to fuse; failure of this process leads to cleft palate, a common birth defect that can occur alone or as part of many syndromes. The dynamics of the elevation process are not understood; therefore, we aim to study normal and abnormal palatal shelf elevation as well as the effect of maternal folic acid supplementation, using novel mouse mutants, cellular and molecular analyses, and in utero time-lapse imaging. Knowledge of palatal shelf elevation dynamics at the tissue, cellular and molecular levels will help identify the etiology and potential therapeutic strategies in patients with orofacial clefts.

PI_NAMEs: SAADI, IRFAN  (contact)

PROGRAM_OFFICER_NAME: SAIFUDEEN, ZUBAIDA

PROJECT_TERMS: Actins;Actomyosin;Affect;Alleles;Anterior;autosome;Bilateral;Binding;Birth;calponin;cell growth regulation;Cell Proliferation;Cells;Child;cleft lip and palate;Cleft Palate;Coiled-Coil Domain;Complex;Computer Models;Congenital Abnormality;Congenital omphalocele;Craniofacial Abnormalities;Cytoplasm;Cytoskeletal Proteins;Cytoskeleton;Data;Defect;Development;driving force;Education;Embryo;Environmental Risk Factor;Etiology;F-Actin;Failure;Female;Finite Element Analysis;Folic Acid;folic acid supplementation;Future;gain of function;Genetic;Growth;Hour;Human;Image;in utero;in vivo;Incidence;innovation;insight;Investigation;Jaw;Knock-in;Knowledge;life time cost;Lip structure;Live Birth;longitudinal analysis;Magnetic Resonance Imaging;Maxilla;Mechanics;Mediating;Medical Care Costs;Mesenchyme;Methodology;Methods;Microtubules;Modeling;Molecular;Molecular Analysis;mouse model;Mus;mutant;Mutant Strains Mice;Mutation;Myosin ATPase;Myosin Type II;non-muscle myosin;novel;Nuclear;Orbital separation excessive;orofacial cleft;palatal shelves;Palate;palatogenesis;Patients;Persons;Phenotype;Point Mutation;Process;Productivity;Proteins;Proteomics;Regulation;Role;Rotation;Scaffolding Protein;serial imaging;Services;Signal Transduction;Stains;Syndrome;Therapeutic;Three-dimensional analysis;three-dimensional modeling;Time;Tissues;Tongue;trafficking;translational approach;translational potential

PROJECT_TITLE: Role of SPECC1L cytoskeletal protein in palate elevation dynamics

STUDY_SECTION: SBDD

STUDY_SECTION_NAME: Skeletal Biology Development and Disease Study Section[SBDD]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Congenital Structural Anomalies;Pediatric;Rare Diseases

ORG_CITY: MEMPHIS

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

ORG_STATE: TN

PHR: Project Narrative (Relevance Statement): The Sonic Hedgehog (SHH) signal transduction pathway is an essential regulator of organ and tissue development that when corrupted leads to developmental disorders and cancers. The goals of my research are to define the mechanisms by which SHH is deployed from its site of synthesis to reach cellular targets with temporal and spatial precision for induction of specific responses in receiving cells. Knowledge obtained from the proposed studies will enhance our understanding of the mechanisms controlling an essential developmental process and may reveal novel methods of targeting the SHH pathway in disease.

PI_NAMEs: OGDEN, STACEY KATHRYN (contact)

PROGRAM_OFFICER_NAME: LEWIS, MECHELLE MAYLEBEN

PROJECT_TERMS: Adult;Basal cell carcinoma;Basal Cell Nevus Syndrome;Cells;cellular targeting;Cilia;Development;developmental disease;Developmental Process;Disease;G-Protein-Coupled Receptors;Genetic Transcription;Goals;hedgehog signal transduction;Holoprosencephaly;Homeostasis;interest;Knowledge;Laboratories;Ligands;Malignant Neoplasms;Medulloblastoma;Methods;Molecular;Morphogenesis;morphogens;novel;Organ;Pallister-Hall syndrome;Pathway interactions;Process;Research;response;SHH gene;Signal Transduction;Signal Transduction Pathway;Site;smoothened signaling pathway;Sonic Hedgehog Pathway;Syndrome;Therapeutic;Tissues;Transcription Coactivator;tumor;Work

PROJECT_TITLE: Mechanisms of Sonic Hedgehog Signal Transduction

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Genetics;Hematology;Human Genome;Infectious Diseases;Orphan Drug;Rare Diseases;Sepsis

PHR: PROJECT NARRATIVE Candidemia is the most common invasive fungal species in hospital settings worldwide, causing about 65% of systemic candidiasis infections. The mortality rate for these infections is 40% despite treatment with antifungal therapies. The goal of this research is to determine if pathogen-induced epigenetic changes exist in patients infected by C. albicans and MRSA that drive immunologic functions shaping antibiotic-persistent from resolving and survival outcomes.

PI_NAMEs: REED, ELAINE F (contact)

PROJECT_TERMS: adaptive immune response;adaptive immunity;Address;Affect;Anti-Infective Agents;Antibiotic Therapy;Antibiotics;Antifungal Therapy;Antigen Presentation;Attenuated;Automobile Driving;beta-Glucans;Big Data;Biological Assay;Biometry;Blood specimen;Candida albicans;candidemia;Candidiasis;cathelicidin antimicrobial peptide;chemokine;ChIP-seq;Chromatin;chronic infection;Clinical;Clinical Research;Coculture Techniques;Communicable Diseases;Computer Analysis;Computer Models;cytokine;Data;Death Rate;diagnostic tool;Disease Outcome;Disseminated candidiasis;DNA Methylation;Enhancers;Enzymes;Epigenetic Process;epigenome;epigenomic profiling;epigenomics;Experimental Models;Genetic;Genetic Transcription;Goals;Hematogenous;Hematology;Histone Acetylation;histone methylation;Hospitals;Human;Immune;immune function;Immune response;Immune Response Genes;Immune system;Immunity;Immunology;In Vitro;in vivo;Infection;infection rate;inhibitor;innate immune function;Innate Immune Response;innovation;insight;Integration Host Factors;Interferon alpha;Interferon Type II;Intervention;Life;Link;machine learning model;Macrophage;Maps;Mediating;methicillin resistant Staphylococcus aureus;methylation pattern;Modification;Molecular;Multi-Drug Resistance;multiple omics;Mus;mutant;Myeloid Cells;Natural Immunity;network models;Nitrous Oxide;novel;Outcome;Oxygen;pathogen;Pathologic;Pathway interactions;Patients;Peripheral;peripheral blood;Phagocytosis;pharmacologic;Plasma;predictive modeling;predictive signature;programs;promoter;prophylactic;Prophylactic treatment;Proteomics;Research;response;Role;Sepsis;Shapes;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Specificity;Staphylococcus aureus;Staphylococcus aureus infection;statistical learning;Stimulus;Sulfides;Surface;survival outcome;System;Systems Biology;T cell response;T-Cell Activation;T-Lymphocyte;targeted treatment;therapeutic development;therapeutic target;TNF gene;Training;transcription factor;transcriptome;transcriptome sequencing;transcriptomics;Vaccines;Validation;whole genome

PROJECT_TITLE: Human Immunomics & Trained Immunity in Persistent Candidemia


ORG_CITY: LOS ANGELES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: RELEVANCE TO PUBLIC HEALTH - Overall Our Program Project Grant (PPG) is devoted to the study of chronic myocardial infarction and sudden cardiac death, two of our nation’s most pressing public health problems. Our PPG will use new tools to examine basic mechanisms by which myocardial scars, created after infarction, interact with altered nerves around them to increase the susceptibility to ventricular arrhythmias and sudden cardiac death.

PI_NAMEs: SHIVKUMAR, KALYANAM  (contact)

PROGRAM_OFFICER_NAME: BALIJEPALLI, RAVI C

PROJECT_TERMS: 3-Dimensional;Address;Adrenergic beta-Antagonists;Angiotensin Receptor;Arrhythmia;Autonomic nervous system;beneficiary;Biochemical;Cardiac;Cardiac ablation;cardiac implant;Cardiac Myocytes;Cardiomyopathies;cell type;Cells;Cessation of life;Chronic;Cicatrix;clinically relevant;Collaborations;Complex;Defibrillators;Detection;Disease;Doctor of Philosophy;Dose;EFRAC;Electrophysiology (science);Eligibility Determination;Ensure;Etiology;experience;Functional disorder;Goals;Health;Heart;Heart Diseases;Heart Injuries;Heterogeneity;high resolution imaging;human disease;Immune;Implantable Defibrillators;In Vitro;in vivo;Infarction;Inflammation;inhibitor;injured;innovation;insight;Ischemia;Knowledge;Lead;Left Ventricular Ejection Fraction;Left Ventricular Function;Maps;Measurement;Medical;Medicare;Molecular;mortality;Muscle Cells;Myocardial;Myocardial Infarction;Myocardial Ischemia;Myocardium;Nerve;nerve supply;neural;Neuroglia;Neuronal Dysfunction;Neurons;Neuropeptides;neuroregulation;Neurosecretory Systems;Neurostimulation procedures of spinal cord tissue;neurotransmission;neurotransmitter release;Neurotransmitters;Nonpharmacologic Therapy;Normal tissue morphology;novel;Organism;Pathway interactions;Patient Care;Patients;Pattern;Peptides;Peptidyl-Dipeptidase A;Physiological;porcine model;Predisposition;prevent;Process;Prognosis;Program Research Project Grants;programs;Public Health;Quality of life;Recurrence;Reflex action;Relapse;Reproducibility;response;Risk;Role;Seminal;Shock;Source;spatiotemporal;standard of care;Stream;Structure;Structure of stellate ganglion;success;sudden cardiac death;Sympathectomy;Sympathetic Nervous System;Tachyarrhythmias;Techniques;Technology;Testing;Therapeutic;Time;Tissues;tool;United States;Ventricular;Ventricular Arrhythmia;Ventricular Tachycardia

PROJECT_TITLE: Cardiac Neuromodulation: Mechanisms and Therapeutics

STUDY_SECTION: HLBP

STUDY_SECTION_NAME: Heart, Lung, and Blood Program Project Study Section[HLBP(JA)]


NIH_SPENDING_CATS: Cardiovascular

PROJECT_TERMS: Accounting;Administrative Efficiency;Agreement;Animal Experimentation;Animals;Annual Reports;Archives;Bibliography;California;Cardiac;Chronic;Coffee;Collaborations;Communication;Computer Assisted;computer network;Computer software;Contract Services;Data;data management;data repository;data sharing;Electronic Mail;Equipment;Expenditure;experience;Funding;Health;heart rhythm;Housing;Human Resources;human tissue;Institutional Review Boards;International;laboratory equipment;Letters;Location;Logistics;Manuscripts;material transfer agreement;Medicine;meetings;Modeling;National Heart, Lung, and Blood Institute;neuroregulation;Notification;operation;pre-clinical;pre-clinical research;Preparation;preservation;Procedures;Program Research Project Grants;programs;Progress Reports;Protocols documentation;Publications;Radiation;Reagent;Reporting;Research;Research Activity;Resources;Safety;Schedule;Scientist;skills;Strategic Planning;Structure;Supervision;symposium;System;Technology;Therapeutic;Time;Tissue Procurements;Training;Translating;Transportation;Travel;United States National Institutes of Health;Universities;Vendor;Word Processing;Work;Writing

PROJECT_TITLE: Administrative Core

STUDY_SECTION_NAME: Heart, Lung, and Blood Program Project Study Section[HLBP]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer

ORG_CITY: ATLANTA

ORG_DEPT: CHEMISTRY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Public Health Relevance The Center proposal aims to develop and disseminate new technologies to measure the mechanical forces in living cells. If successful, these new technologies will reveal the forces that guide cellular processes such as normal and abnormal cell growth, immune responses, and clotting. As such, center technologies will improve our ability to diagnose and treat diseases ranging from cancer metastasis to stroke.

PI_NAMEs: SALAITA, KHALID S. (contact)

PROGRAM_OFFICER_NAME: FLICKER, PAULA F

PROJECT_TERMS: Abnormal Cell;Acceleration;Adaptive Immune System;Address;adhesion receptor;Adoption;Affect;Apple;Architecture;Automobile Driving;Binding;Biomedical Technology;Blood Platelets;Blood Transfusion;cancer cell;Cardiopulmonary Bypass;cell growth;Cell Physiology;Cell Surface Receptors;Cells;Cellular biology;Clinical Research;Coagulation Process;Collaborations;commercialization;Communities;community engagement;Custom;Data Analyses;design;Diagnosis;Disease;Dissociation;DNA;DNA amplification;DNA Probes;DNA Structure;Educational workshop;Embryo;Ensure;Enzyme-Linked Immunosorbent Assay;Event;Extramural Activities;Fees;Flow Cytometry;Fluorescence Polarization;Focal Adhesions;force sensor;Frequencies;Functional disorder;Geography;Goals;Growth;Heterogeneity;high throughput analysis;Image;Immune response;improved;Industry;interest;Internet;Invaded;Knowledge;Life;Mainstreaming;Malignant neoplasm of lung;Maps;Measures;mechanical force;mechanical signal;Mechanics;mechanotransduction;Mediating;Methods;Microscope;Molecular;Molecular Probes;nanoscale;National Institute of General Medical Sciences;Neoplasm Metastasis;new technology;Normal Cell;Pathway interactions;Patients;Peer Review;Preparation;Process;Proteins;Proteomics;Protocols documentation;prototype;public health relevance;Publications;Publishing;Reader;Reagent;receptor;recruit;Research Personnel;Resolution;response;Role;Seminal;Series;Services;Signal Transduction;Stroke;Structure;Surface;symposium;System;T-Cell Immunologic Specificity;T-Cell Receptor;T-Lymphocyte;Techniques;Technology;technology development;Testing;Time;tool;Traction;Training;virtual;Weight;Work

PROJECT_TITLE: Center on Probes for Molecular Mechanotechnology

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-T(55)S]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Heart Disease;Neurosciences;Organ Transplantation;Transplantation

PI_NAMEs: AJIJOLA, OLUJIMI A (contact)

PROJECT_TERMS: 3-Dimensional;Achievement;Adrenergic Agents;Biological;Cardiac;Cardiomyopathies;cell type;Chemicals;Cicatrix;cost;Data Set;Ensure;experience;Family suidae;Functional disorder;Goals;Heart;Heart Diseases;Heart Transplantation;high resolution imaging;Human;human disease;Human Resources;human tissue;Image;Infrastructure;innovation;instrumentation;Ion Channel;Lasers;Link;Lung;Maps;member;Methods;Molecular;Molecular Biology;mortality risk;Myocardial;neural;neuroregulation;neurotransmission;Organ Procurements;Organ Transplantation;Patients;Penetration;Process;Productivity;Protocols documentation;Pulmonary Heart Disease;Recovery;Research Personnel;Resolution;Services;Structure;Structure of stellate ganglion;success;Sudden Death;Techniques;Testing;Therapeutic;Time;Tissue Procurements;Tissues;transcriptomics;Validation

PROJECT_TITLE: Core A: Ultrastructural Assessment & Human Tissue


ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Project Narrative The proposed research will develop an electrochemical strategy to selectively transform alkenes into densely functionalized compounds of medicinal importance. Ultimately, the proposed project will facilitate the development and large-scale preparation of new pharmaceuticals while simultaneously reducing the cost of life-changing medicines.

PI_NAMEs: WICKENS, ZACHARY KIMBLE (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TITLE: electrochemical dication pool: a new strategy to couple alkenes and abundant nucleophiles

STUDY_SECTION: SBCA

STUDY_SECTION_NAME: Synthetic and Biological Chemistry A Study Section[SBCA]


NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Clinical Research;Heart Disease;Heart Disease - Coronary Heart Disease;Neurosciences

PI_NAMEs: ARDELL, JEFFREY L (contact)

PROJECT_TERMS: Animals;Area;bioelectronics;Biological Markers;Blood Vessels;Cardiac;Catecholamines;Characteristics;Chronic;Conscious;Coupled;Data;Dedications;design;Detection;Devices;Electrodes;Electrophysiology (science);Epicardium;experience;Family suidae;FDA approved;Film;Goals;Heart;heart rate monitor;Heterogeneity;high risk;Human;Implant;In Vitro;Infarction;instrumentation;Maps;Measurement;Measures;Modeling;Monitor;Myocardial Infarction;Myocardial Ischemia;Myocardium;Nerve;Nervous System;neural;neurochemistry;Neuropeptides;neuroregulation;neurotransmitter release;Neurotransmitters;Operative Surgical Procedures;Optics;Pathology;Patients;Periodicity;Phase;porcine model;Pre-Clinical Model;Preparation;programs;Research;Resolution;Structure of stellate ganglion;sudden cardiac death;Technology;Telemetry;Temperature;temporal measurement;Therapeutic;Therapeutic Intervention;Thinness;Time;Titrations

PROJECT_TITLE: Core B: Functional Assessment & Instrumentation


ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Project Narrative This research aims to develop new chemistry that will be useful to the synthesis of potential pharmaceuticals. The understanding of this new chemistry and the optimization of the desired reaction outcomes will expand the types of structures of potential drugs that chemists can synthesize, thereby increasing the chances of success in developing new classes of drugs for unmet medical needs.

PI_NAMEs: HILINSKI, MICHAEL KENNETH (contact)

PROJECT_TERMS: Acceleration;Acids;Address;Amination;Amines;Area;Biological;cancer therapy;Catalysis;catalyst;Chemicals;Chemistry;cycloaddition;Diels Alder reaction;direct application;driving force;drug discovery;flexibility;Foundations;Future;Goals;Hydrogen Bonding;Hydroxylation;invention;Investments;Laboratories;Medical;Metals;Methods;Nitrogen;novel;novel drug class;Organic Synthesis;Outcome;Pharmaceutical Preparations;Pharmacologic Substance;Preparation;programs;Reaction;Research;Site;small molecule;small molecule therapeutics;Sodium Chloride;Structure;success;Variant;virtual

PROJECT_TITLE: New Catalysts and Strategies for Selective C–H Functionalization and Cycloaddition Reactions

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


ORG_CITY: NEW ORLEANS

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: Project Narrative Reversal of latent HIV-1 to its transcriptionally active form represents possibly the only way in which a latent HIV-1 infected cell can be identified. Our proposed studies aim to examine the role of a dietary hormone, insulin, on promoting latent HIV-1 transcription. In the long-term, the proposed studies will hope to provide a rationale for studying current and future HIV-1 cure therapies in persons living with HIV-1 who also have Type 2 Diabetes.

PI_NAMEs: MUDD, JOSEPH CHRISTOPHER (contact)

PROGRAM_OFFICER_NAME: LAWRENCE, DIANE M

PROJECT_TERMS: Age;Animals;anti-CTLA4;anti-PD-1;antiretroviral therapy;Binding;Biological Products;Blood;Blood Glucose;CD4 Positive T Lymphocytes;Cells;Clinical;clinical implementation;Clinical Trials;cohort;comorbidity;CTLA4 blockade;CTLA4 gene;Defect;Diet;dietary;Dietary Factors;Dietary intake;DNA;Eating;Enzymes;experimental study;FOXO1A gene;FRAP1 gene;Future;Gender;General Population;Genetic Transcription;Genome;Glucose;glucose uptake;Glycolysis;Goals;Heterogeneity;HIV;HIV-1;Hormone imbalance;Hormones;Hour;Human;Impairment;in vivo;Infection;Insulin;Insulin Receptor;insulin signaling;interest;Intermittent fasting;Life Cycle Stages;Macaca mulatta;Measurable;Measures;memory CD4 T lymphocyte;Metabolic;Methods;Modeling;Nature;Non-Insulin-Dependent Diabetes Mellitus;nuclear factors of activated T-cells;Patients;PD-1 blockade;Persons;phosphoproteomics;Phosphorylation;Phosphorylation Site;PIK3CG gene;Plasma;Population;Positioning Attribute;pre-clinical;preclinical trial;Prevalence;Process;Production;programmed cell death protein 1;promoter;Proviruses;purge;reactivation from latency;Regulation;Rest;Risk;RNA;Role;Sampling;Serum;Shock;Signal Pathway;Signal Transduction;SIV;synergism;Testing;Time;transcription factor;Up-Regulation;Viral;viral resistance;Virus Latency;western diet;Work

PROJECT_TITLE: The intersection of diet, cell metabolic state, and SIV reservoir transcription

STUDY_SECTION: HIVD

STUDY_SECTION_NAME: HIV Immunopathogenesis and Vaccine Development Study Section[HIVD]


NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Clinical Research;Heart Disease;Heart Disease - Coronary Heart Disease;Neurosciences;Prevention;Transplantation

PROJECT_TERMS: Action Potentials;Adrenergic Antagonists;Animal Model;Animals;Anti-Arrhythmia Agents;Antiinflammatory Effect;Area;Arrhythmia;Attenuated;Autonomic nervous system;Cardiac;Cardiac Myocytes;Cardiomyopathies;Cardiovascular Diseases;Cessation of life;Chronic;Cicatrix;Computer Assisted;Computer Models;Computer Vision Systems;data integration;Data Set;density;Disease;Disease Progression;disorder prevention;Donor person;Electrophysiology (science);Ensure;Exhibits;Family suidae;Functional disorder;Goals;Health;Heart;Heart Diseases;Heart failure;Heart Transplantation;Heterogeneity;Human;Hypertension;Implant;In Vitro;in vivo;Individual;individual response;Infarction;Inflammation;Intervention;Ischemia;ischemic cardiomyopathy;Kinetics;Lead;Left Ventricular Ejection Fraction;Link;Location;Maps;Measurement;Measures;Mechanics;Mediating;Morbidity - disease rate;mortality;Muscle Cells;Myocardial;Myocardial Infarction;Myocardial Ischemia;Myocardium;Nerve;nerve supply;Nervous System;neural;neuromechanism;Neurons;Neuropeptides;neuroregulation;neurotransmitter release;Neurotransmitters;Pathologic;Patients;Pattern;Peptides;Perfusion;Periodicity;physiologic stressor;Physiological;Play;Preparation;Prevention therapy;Process;protective effect;Reflex action;response;Risk;Role;Scanning;Signal Transduction;spatiotemporal;Stimulus;stoichiometry;Structure;Structure of stellate ganglion;sudden cardiac death;Sudden Death;Sympathectomy;targeted treatment;Techniques;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;Time;Tissues;Transplantation;United States;Ventricular;Ventricular Arrhythmia;Ventricular Tachycardia

PROJECT_TITLE: Neural Control of Myocardial Excitability at the Nerve Myocyte Interface


ADMINISTERING_IC: NS

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Biomedical Imaging;Chronic Pain;Clinical Research;Complementary and Integrative Health;Fibromyalgia;Neurosciences;Pain Research

ORG_CITY: ANN ARBOR

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE The proposed research is relevant to public health as many patients with Chronic Overlapping Pain Conditions (COPCs) often complain of general hypersensitivity to touch, sound and everyday light. This research will identify neural signatures of hypersensitivity among chronic pain patients through investigating functional (F99) and casual (K00) interactions between sensory and pain processing brain regions to enhance our understanding of COPCs and lead to future studies on how to adjust altered sensory processing through interventions. Thus, the proposed research is relevant to the part of the NIH's mission that pertains to uncovering new knowledge through translational neuroscience research that will help detect and reduce the burden of hypersensitivity among patients with chronic pain.

PI_NAMEs: LARKIN, TONY EDWARD (contact)

PROGRAM_OFFICER_NAME: GREENWELL, THOMAS

PROJECT_TERMS: allodynia;Anterior;Area;Brain;Brain region;Central Nervous System;Central Nervous System Diseases;central pain;Chronic;chronic pain;chronic pain patient;clinical pain;Communication;Complex;Computing Methodologies;Data;Diffuse;experience;Fibromyalgia;flexibility;Functional disorder;functional group;Functional Magnetic Resonance Imaging;Future;Goals;gray matter;Headache;healthy volunteer;Hyperalgesia;Hypersensitivity;Impairment;Individual;insight;Insula of Reil;Interstitial Cystitis;Intervention;Intestines;Knowledge;Learning;Light;Low Back Pain;Measures;Mission;Multimodal Imaging;multisensory;network architecture;neural;neurochemistry;neuromechanism;Neurosciences Research;Nociception;novel;Odors;Pain;pain perception;pain processing;Participant;Pathway Analysis;Pathway interactions;Patients;Phase;Photic Stimulation;Play;Property;Public Health;Research;response;Rest;Role;Sensory;sensory integration;sensory stimulus;somatosensory;sound;Stimulus;Structure;Temporomandibular Joint Disorders;Testing;Thalamic structure;Thinking;Touch sensation;Training;translational neuroscience;United States National Institutes of Health;Visual;visual processing;visual stimulus;Work

PROJECT_TITLE: Investigating neural mechanisms of hypersensitivity in chronic pain


NIH_SPENDING_CATS: Biotechnology;Genetics;Infectious Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: CORAL GABLES

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: Project Narrative Chronic viral infections are an increasingly common occurrence in the United States. Patients with chronic viral infections can have high morbidity and mortality rates due to progressive organ damage. This research program seeks to elucidate cell type and tissue specific molecular mechanisms that drive the progression of disease in these patients and to subsequently identify new targets for therapeutic invention.

PI_NAMEs: THOMAS, EMMANUEL  (contact)

PROGRAM_OFFICER_NAME: ZHAO, XIAOLI

PROJECT_TERMS: 3-Dimensional;Acute;Address;anti-microbial peptide;Anti-viral Response;cell type;Cells;Chronic;chronic infection;Death Rate;defense response;Development;Disease;Disease Progression;DNA;Drosophila genus;Epigenetic Process;epigenetic regulation;Epithelial Cells;Fat Body;fighting;Gene Expression;Gene Expression Profile;Goals;Host Defense;Human;human disease;Immune;Immune response;in vitro Model;induced pluripotent stem cell;Inflammation;Innate Immune Response;Innate Immune System;Interferons;Invaded;invention;Liver;Microfluidics;Modeling;Modification;Molecular;Morbidity - disease rate;Natural Immunity;new therapeutic target;novel;novel strategies;Organ;pathogen;Pathogenesis;pathogenic virus;Pathogenicity;Pathway interactions;Patients;Pattern;Pattern recognition receptor;Post-Translational Protein Processing;programs;Property;Research;response;RNA;Signal Pathway;Signaling Molecule;Tissues;TLR3 gene;transcription factor;Transformed Cell Line;United States;Viral;Virus;Virus Diseases;Virus Replication

PROJECT_TITLE: A Multifaceted Approach to Study Tissue and Cell Type Specific Molecular Mechanisms of the Host Response to Acute/Chronic Viral Infection


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Heart Disease;Heart Disease - Coronary Heart Disease;Neurosciences;Prevention

PI_NAMEs: HARVEY, ROBERT D (contact)

PROJECT_TERMS: Acetylcholine;Action Potentials;Adrenergic Agents;Affect;American;Anatomy;Animal Model;Area;Arrhythmia;autonomic nerve;Biochemical;Cardiac;Cell Separation;Cells;Chronic;Computer Models;Data;Dependence;Disease;electrical property;Electrophysiology (science);Event;experimental study;Family suidae;Foundations;Generations;healing;Heart;heart electrical activity;Heart failure;Heart Transplantation;Heterogeneity;Human;immunocytochemistry;improved;Incidence;Individual;Infarction;Ion Channel;Life;Link;Measures;Mediating;Miniature Swine;Modeling;Molecular Biology;Muscle Cells;Myocardial Infarction;Myocardium;Nerve;neuropeptide Y;neuroregulation;Neurotransmitters;Norepinephrine;Patch-Clamp Techniques;Persons;pharmacologic;prevent;Prevention;programs;Property;Recovery;Regulation;response;Role;sudden cardiac death;Techniques;Testing;Therapeutic;Tissue Survival;Tissues;translational study;Transplantation;Vasoactive Intestinal Peptide;Ventricular;Ventricular Arrhythmia;Vision

PROJECT_TITLE: Cellular Basis for Autonomic Regulation of Cardiac Arrhythmias


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Diabetes;Eye Disease and Disorders of Vision

ORG_CITY: AUGUSTA

ORG_NAME: AUGUSTA UNIVERSITY

PHR: We hypothesize that the cornea routinely suffers minor traumas from, for example, aggressive eye rubbing, which lead to quickly repairable injuries of the plasma membrane of corneal cells. These repairable injuries allow a burst calcium of to enter the cells, which in turn triggers signaling events that result in intercellular calcium waves. We propose to examine the signaling pathways that lead to this corneal calcium wave response along with the physiological consequences of those calcium waves, and how they contribute to corneal health in normal and diabetic corneas.

PI_NAMEs: WATSKY, MITCHELL A (contact)

PROGRAM_OFFICER_NAME: MCKIE, GEORGE ANN

PROJECT_TERMS: Actins;Affect;Apoptosis;Basic Science;Biomechanics;bone;Calcium;Calcium Oscillations;Cell membrane;Cells;Contact Lenses;Cornea;Corneal Diseases;corneal epithelial wound healing;corneal epithelium;Corneal Stroma;Data;design;Diabetes Mellitus;diabetic;Diabetic mouse;environmental stressor;Event;Eye;Future;Gap Junctions;Genetic;Health;Homeostasis;Human;improved;Individual;Injury;Keratopathy;knock-down;Light Cell;Location;Maintenance;Mechanics;Mediating;Membrane;Messenger RNA;Microscope;Microscopy;migration;Minor;multi-photon;Mus;novel;Osteocytes;Pathology;Pathway interactions;pharmacologic;Physiological;Predisposition;Proliferating;Protein Biosynthesis;Proteins;Publishing;receptor;response;Signal Pathway;Signal Transduction;Signaling Molecule;Signaling Protein;Small Interfering RNA;Stress;stressor;System;Testing;Time;Tissues;Trauma;TRPV1 gene;Work

PROJECT_TITLE: Temporary plasma membrane disruptions in corneal epithelium and keratocytes.

STUDY_SECTION: BDE

STUDY_SECTION_NAME: Biology and Development of the Eye Study Section[BDE]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Cancer;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Contraception/Reproduction;Diabetes;Infertility;Nutrition;Obesity;Pediatric;Polycystic Ovary Syndrome (PCOS);Precision Medicine;Prevention;Uterine Cancer;Women's Health Research

ORG_CITY: Aurora

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Polycystic ovary syndrome is one of the most common endocrinopathies in women, presents with anovulation in adolescence, and reproductive dysfunction is related to excess weight. After a 4-month observation period of either no medication or metformin treatment, females aged 12-35 years with obesity and polycystic ovary syndrome will receive 10 months of a glucagon-like peptide-1 receptor agonist to induce metabolic changes, weight loss and improve reproductive abnormalities. We will assess the relationship between weight loss and reproductive function, as well as identify if age, hormonal and metabolic measures and such insulin sensitivity and insulin secretion predict the response to glucagon-like peptide-1 receptor agonist therapy.

PI_NAMEs: CREE, MELANIE G (contact)

PROGRAM_OFFICER_NAME: TAYMANS, SUSAN

PROJECT_TERMS: Acne;Adolescence;Adolescent;Adult;Age;age related;aged;Agonist;androgen excess;Androgens;Anovulation;arm;Body Weight decreased;Characteristics;Clinical;Clinical Trials;Combined Modality Therapy;comorbidity;Compensatory Hyperinsulinemia;Data;Desire for food;Diabetes Mellitus;disorder risk;Dose;efficacious treatment;Endometrial Carcinoma;Endometrium;Enrollment;exenatide;experience;Female;Formulation;Frequencies;Functional disorder;girls;GLP-I receptor;Glucose;Health;Hemorrhage;High Prevalence;high risk;Hirsutism;Hormonal;hormonal contraception;Hour;Hyperandrogenism;Hypergravity;Hypothalamic Hormones;improved;indexing;Individual;Insulin;insulin secretion;insulin sensitivity;life span;Life Style;liraglutide;loss of function;Luteinizing Hormone;Measures;Menstrual cycle;Menstruation;Metabolic;Metabolic Diseases;metabolic phenotype;metabolic profile;Metformin;Methods;Modeling;mullerian-inhibiting hormone;Non-Insulin-Dependent Diabetes Mellitus;Obesity;OGTT;Oligomenorrhea;Oral;Outcome;Ovulation;Ovulation Induction;Pattern;personalized medicine;Persons;Pharmaceutical Preparations;Physiology;Polycystic Ovary Syndrome;predicting response;Prediction of Response to Therapy;prevent;Progesterone;Puberty;reproductive;reproductive function;Reproductive Health;reproductive outcome;response;Risk;Risk Factors;Role;Secondary to;Serum;subcutaneous;Testosterone;therapeutically effective;trait;treatment planning;treatment response;trend;urinary;Weight;Woman;women's treatment;Work;Youth

PROJECT_TITLE: Role of semaglutide in restoring ovulation in youth and adults with polycystic ovary syndrome

STUDY_SECTION: ICER

STUDY_SECTION_NAME: Integrative and Clinical Endocrinology and Reproduction Study Section[ICER]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Heart Disease;Heart Disease - Coronary Heart Disease;Neurosciences

PROJECT_TERMS: Action Potentials;Acute;Adrenergic Antagonists;animal data;Animal Model;Animals;Anti-Arrhythmia Agents;Antiinflammatory Effect;Attenuated;Cardiac;cardiac device;cardiac implant;Cardiomyopathies;cardioprotection;Cause of Death;Cell Communication;Cells;Chronic;Clinical Trials;Complex;computerized tools;Coronary;Data;Dose;Electrophysiology (science);Elements;Equilibrium;extracellular;Family suidae;Functional disorder;glial activation;Goals;Heart;Heart Injuries;Heterogeneity;Human;human model;Immune;immune cell infiltrate;improved;in vivo;Infarction;Inflammation;Inflammatory;insight;Intervention;Investigation;Life;Link;Mediating;multidisciplinary;Myocardial;Myocardial dysfunction;Myocardial Infarction;Myocardium;Nerve;Nervous System control;neural;neural network;Neuroanatomy;neurochemistry;neuroinflammation;Neuronal Dysfunction;Neurons;neurophysiology;neuroregulation;neurotransmission;novel;novel strategies;novel therapeutic intervention;Pathway interactions;Pattern;Pharmaceutical Preparations;pharmacologic;Pilot Projects;Predisposition;prevent;Prevention;Process;protective effect;Research Personnel;Resolution;revascularization;side effect;Signal Transduction;spatiotemporal;Structure;Structure of stellate ganglion;sudden cardiac death;Sympathetic Ganglia;Sympathetic Nervous System;Testing;Therapeutic;tool;transcriptomics;Ventricular Arrhythmia;Ventricular Remodeling;Ventricular Tachycardia

PROJECT_TITLE: Antiarrhythmic mechanisms of chronic vagal nerve stimulation in sympathetic neurons


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: INDIANAPOLIS

ORG_NAME: RLR VA MEDICAL CENTER

ORG_STATE: IN

PHR: Roughly 25% men over the age of 50 will suffer an osteoporotic fracture during their senior years, and the 1- year mortality rate following a hip fracture is nearly 2× as high for men as for women. One-fifth of those who were ambulatory before their hip fracture require long-term care afterward. Beyond their age, other lifestyle factors make veterans particularly susceptible to osteoporosis, including smoking, alcohol consumption, and an inactivity. Moreover, many Vietnam veterans were exposed to environmental factors during the war, such as the dioxin TCDD (found in Agent Orange), which put them at much greater risk for osteoporosis. Recently, the VA amended its adjudication regulation to establish a presumption of service connection for osteoporosis for former Prisoners of War (POWs) who were detained or interned for at least 30 days, and more recently, for those diagnosed with posttraumatic stress dis-order (PTSD), and whose osteoporosis is at least 10% disabling. There is a clear need to identify new treatment options for veterans that suffer from low bone mass disease.

PI_NAMEs: ROBLING, ALEXANDER G (contact)

PROJECT_TERMS: Address;adjudication;Affect;Age;agent orange;Aging;Alcohol consumption;Amendment;Anabolism;analog;Area;Automobile Driving;Binding;bisphosphonate;Body Size;Body System;bone;Bone callus;bone fracture repair;bone fragility;bone health;bone loss;bone mass;Bone Matrix;bone quality;Bone Regeneration;bone repair;Bone Resorption;bone strength;Bone structure;Bone Tissue;Cartilage;cell type;Clinical;Clinical Management;Collaborations;cost effective;Data;Death Rate;Deterioration;Diagnosis;Dioxins;Disabling;Disease;disease model;Early Diagnosis;Ensure;Environmental Risk Factor;Exercise;Exhibits;Exposure to;Forteo;Fracture;fracture risk;fragility fracture;Gene Expression Profile;Goals;Health;Hip Fractures;hormonal signals;Hospitals;Hydration status;Impairment;improved;in vitro Model;in vivo;innovation;insight;interest;Internships;Knock-out;Life Style;lifestyle factors;Link;Long-Term Care;Measures;mechanical load;mechanical signal;Mechanical Stimulation;mechanical stimulus;Mechanics;mechanotransduction;Mediating;Mediator;men;Modeling;Molecular;Molecular Profiling;Molecular Target;Morbidity - disease rate;mortality;mouse genome;Mus;Musculoskeletal Pain;mutant;Mutant Strains Mice;novel;novel strategies;Nuclear Matrix;Osteocytes;Osteogenesis;osteogenic;Osteoporosis;Osteoporosis prevention;osteoporosis with pathological fracture;Outcome Measure;Pharmaceutical Preparations;pharmacologic;Pharmacologic Substance;Phenotype;Post-Traumatic Stress Disorders;Pre-Clinical Model;Predisposition;Prevention approach;Prisoner;programs;Property;Proteins;Proteoglycan;PTH gene;Regimen;Regulation;Research;Research Personnel;research study;response;Risk;Services;side effect;Signal Pathway;Signal Transduction;Site;skeletal;Skeleton;Smoking;Stimulus;sugar;Techniques;Testing;Tetrachlorodibenzodioxin;Therapeutic;Tissues;tool;treatment effect;treatment strategy;Veterans;Vietnam;War;Water;Woman;Work;Zinc Fingers

PROJECT_TITLE: BCCMA: Foundational Research to Act Upon and Resist Conditions Unfavorable to Bone (FRACTURE CURB): Zfp384-mediated enhancement of anabolic action in the skeleton


NIH_SPENDING_CATS: Biotechnology;Contraception/Reproduction;Genetics;Infectious Diseases;Infertility;Sexually Transmitted Infections;Women's Health Research

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Chlamydia infections have a large negative impact on women’s reproductive health. We propose to catalogue the cellular and gene expression events occurring from initial infection, to resolution, to fibrotic damage post bacterial clearance in a female mouse model of upper genital tract infections. These studies will provide a unique resource for the characterization of infection-associated inflammatory processes and fibrotic damage during Chlamydia infections.

PI_NAMEs: VALDIVIA, RAPHAEL H (contact)

PROGRAM_OFFICER_NAME: VINCENT, LEAH REBECCA

PROJECT_TERMS: Acute;acute infection;Animal Model;Architecture;Bacteria;Catalogs;cell type;Cells;Chlamydia;Chlamydia Infections;Chlamydia muridarum;Chlamydia trachomatis;Chronic;chronic infection;Cicatrix;Data Set;Epithelium;Event;Female;female reproductive tract;Fibrosis;Freezing;Gene Expression;Gene Expression Profile;Gene Expression Profiling;Genetic Transcription;Genomics;Goals;Hormones;Human;Immune;immune cell infiltrate;Immunologics;Infection;Infertility;Inflammatory;insight;Integration Host Factors;Longitudinal Studies;Mammalian Oviducts;Mediating;Molecular;Monitor;mouse model;Mus;mutant;Organ;pathogen;pathogenic bacteria;Pathologic;Pathology;Pelvic Inflammatory Disease;Phenotype;Plasmids;Play;Pregnancy;Process;repaired;Reproductive Health;reproductive tract;Resolution;Resources;response;Role;Sexual Transmission;single-cell RNA sequencing;Spatial Distribution;System;Technology;tissue repair;Tissues;transcriptomics;Vagina;Virulence;Virulence Factors;women's reproductive health

PROJECT_TITLE: A spatial transcriptional analsysis of Chlamydia-mediated upper genital tract pathology

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIB-J(90)]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cardiovascular;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Pain Research;Physical Activity;Physical Rehabilitation;Prevention;Rehabilitation

ORG_CITY: OKLAHOMA CITY

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PHR: PROJECT NARRATIVE  The NICE program, in which people with peripheral artery disease walk slower and for shorter periods of intermittent pain-free walking than the Standard exercise program of eliciting leg pain, will be a new exercise method to optimally improve walking ability, quality of life, vascular function, and vascular biomarkers. These improvements from the NICE program could improve the quality of life of Americans with peripheral artery disease by leading to healthier and more active lifestyles.

PI_NAMEs: GARDNER, ANDREW W (contact)

PROGRAM_OFFICER_NAME: RADZISZEWSKA, BARBARA

PROJECT_TERMS: active lifestyle;Acute;Adherence;Affect;Age Years;American;Biological Markers;Blood flow;Blood Pressure;Blood Vessels;C-reactive protein;claudication;Clinical;clinically relevant;clinically significant;comparative effectiveness;Comparative Effectiveness Research;cost;Death Rate;Dropout;efficacious intervention;Exercise;exercise adherence;exercise intervention;exercise prescription;exercise program;exercise rehabilitation;Exercise Therapy;exercise training;Functional disorder;Goals;health related quality of life;Home;human old age (65+);improved;Inflammation;innovation;Institute of Medicine (U.S.);Intermittent Claudication;Investigation;Ischemia;Knowledge;Leg;Lower Extremity;Meta-Analysis;Methods;Monitor;Muscle;novel;Outcome;Oxidative Stress;oxidized low density lipoprotein;Oxygen;Pain;Pain Free;Pain in lower limb;patient oriented;Patients;Peripheral arterial disease;Persons;Physical Function;primary outcome;Production;programs;Publishing;Quality of life;Randomized;Randomized, Controlled Trials;Reactive Oxygen Species;Recommendation;Reflex action;response;secondary outcome;Seminal;Speed;standard of care;Stimulus;Structure;Symptoms;Testing;Time;treadmill;treatment strategy;Walking;walking program;walking speed;Work

PROJECT_TITLE: The effects of a novel, non-ischemic and pain-free exercise intervention in peripheral artery disease

STUDY_SECTION: ASG

STUDY_SECTION_NAME: Aging Systems and Geriatrics Study Section[ASG]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

ORG_CITY: WASHINGTON

ORG_NAME: GEORGE WASHINGTON UNIVERSITY

ORG_STATE: DC

PHR: PROJECT NARRATIVE Overall The DC CFAR's mission is to intensify our multi-institutional effort to promote and support research that contributes to ending the HIV epidemic in Washington, DC and beyond in partnership with government and community. The CFAR achieves this mission by providing scientific and administrative leadership to advance HIV research among the eight collaborating DC CFAR institutions; stimulating and supporting innovative and consequential HIV research in the basic, clinical, prevention and social and behavioral sciences; driving the development and recruitment of early stage, new, and women and underrepresented minority HIV investigators; and enhancing communication and fostering meaningful new collaborations between DC CFAR investigators and academic, government, community and clinical partners.

PI_NAMEs: GREENBERG, ALAN EDWARD (contact)

PROGRAM_OFFICER_NAME: REFSLAND, ERIC WILLIAM

PROJECT_TERMS: Achievement;Acquired Immunodeficiency Syndrome;Address;Adult;AIDS prevention;American;Area;Articulation;Automobile Driving;Award;base;Basic Science;Behavioral Sciences;black men;Capital;Child;Cities;Clinical;Clinical Sciences;Collaborations;Communication;Communities;community engagement;comorbidity;Consultations;design;Development;District of Columbia;Epidemic;epidemic response;Evaluation;Fostering;Foundations;Funding;Future;Government;Grant;Growth;Health;health data;health inequalities;Health system;high risk;HIV;HIV diagnosis;implementation science;Infrastructure;innovation;Institution;interdisciplinary approach;Investments;Lead;Leadership;Manuscripts;Medical center;meetings;Mentors;Mission;Modeling;multidisciplinary;Newly Diagnosed;Population Sciences;Positioning Attribute;pre-exposure prophylaxis;Prevention;programs;Public Health;Publishing;recruit;Reporting;Research;Research Activity;Research Personnel;Research Support;response;scale up;Science;Services;Site Visit;Social Sciences;Underrepresented Minority;United States Department of Veterans Affairs;United States National Institutes of Health;Universities;Update;Vision;Washington;webinar;Woman;working group

PROJECT_TITLE: District of Columbia Center for AIDS Research


ORG_NAME: PORTLAND VA MEDICAL CENTER

PHR: Extremity trauma has been a significant combat casualty for military personnel, comprising 58% to 88% of combat wounds, in recent US armed conflicts. These injuries often result in long term functional disabilities and predispose soldiers to chronic pathologies like post-traumatic osteoarthritis. As such, these injuries are a large burden for military personnel, their families, and the whole of the DOD and VA systems. The proposed work will develop new regenerative engineering interventions in combination with rehabilitation therapies that will improve long term functional outcomes for patients after multi-tissue trauma. The outcomes from this work will provide scientific rationale into how quickly the patient can begin to use the limb, how much load to support, and how to implement physical therapy protocols. This information will be disseminated through publications and direct consultation with physical therapist at the Center for the Intrepid and Atlanta VAMC—resulting in improved daily function and ultimately the quality of life of service members, veterans, and their families.

PI_NAMEs: WILLETT, NICK J (contact)

PROJECT_TERMS: 3-Dimensional;Amputation;analytical method;Angiography;Animals;Athletic Injuries;Attenuated;Autologous Transplantation;battlefield injury;Blood Vessels;BMP2 gene;bone;bone fracture repair;bone healing;Bone structure;Bone Tissue;Caring;Cell Therapy;Cells;Chronic;chronic pain;Clinical;Collagen;combat casualty;combat injury;combat wound;Communication;Consultations;daily functioning;Data;Defect;Dose;efficacy evaluation;efficacy testing;Encapsulated;Engineering;Exercise;exercise intensity;exercise intervention;exercise training;Extracellular Matrix;Family;Fiber;functional disability;functional improvement;functional outcomes;Gait;healing;Histology;Hydrogels;Impairment;Implant;improved;Injury;insight;Intervention;Isometric Exercise;limb injury;Limb Salvage;Limb structure;Literature;Mechanical Stimulation;Mechanics;member;Methods;microCT;Military Personnel;Modeling;Muscle;Muscle Fibers;muscle progenitor cell;muscle regeneration;Muscular Atrophy;muscular structure;Natural regeneration;nerve supply;Neurologic Dysfunctions;Operative Surgical Procedures;Outcome;Outcome Measure;Pain;Pathology;Patient-Focused Outcomes;Patients;physical therapist;Physical therapy;Pre-Clinical Model;Production;Protocols documentation;Publications;Publishing;quadriceps muscle;Quality of life;Rattus;regenerative;regenerative approach;Regenerative engineering;Regenerative Medicine;regenerative rehabilitation;regenerative therapy;Regimen;Rehabilitation therapy;reinnervation;repaired;Research;restoration;revascularization;Role;Running;scaffold;Series;service member;severe injury;Severities;Soldier;stem;System;Testing;Thick;Tissue Engineering;tissue injury;tissue regeneration;tissue trauma;Tissues;Torque;Transplantation;Trauma;Traumatic Arthropathy;treadmill;Treatment Efficacy;treatment group;Treatment Protocols;Vascularization;Veterans;volumetric muscle loss;Work

PROJECT_TITLE: Combined Regenerative and Rehabilitation Therapies for Extremity Trauma

STUDY_SECTION_NAME: Regenerative Rehabilitation[RRD0]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

PHR: Project Narrative: Decreasing food intake through Dietary Restriction (DR) is a well-studied intervention that extends lifespan across taxa. This project focuses on how the perception of food through mechanosensation, or food touch, can diminish the benefits of DR in the nematode C. elegans. The resulting data will provide insight into how multiple modes of food perception are integrated by the nervous system to effect health and longevity.

PI_NAMEs: KITTO, ELIZABETH SARAH (contact)

PROGRAM_OFFICER_NAME: SARE, RACHEL

PROJECT_TERMS: Address;Afferent Neurons;Age of Onset;age-related disease;Aging;Animals;Behavior;Biogenic Amines;Biological Assay;Caenorhabditis elegans;Cells;Cellular Structures;Cues;Data;dietary requirement;dietary restriction;Dopamine;dopaminergic neuron;Eating;Elements;Environmental Risk Factor;experience;extend lifespan;Fasting;Fertility;FMO2;Food;food environment;Genes;Genetic;Genetic Transcription;Geroscience;Goals;Growth;Health;healthspan;Human;improved;insight;Intake;Interneurons;Intervention Studies;Intestines;knock-down;Knock-out;Knowledge;Laboratories;lifestyle intervention;Longevity;longevity gene;Malnutrition;Maps;Mediating;Methods;mimetics;model organism;mutant;Nematoda;Nervous System;neural circuit;neuromechanism;Neurons;Neuropeptide Receptor;Neuropeptides;neurotransmission;Neurotransmitter Receptor;neurotransmitter release;Neurotransmitters;novel;Nutrient;Pathway interactions;Perception;Peripheral;Persons;Pharmacologic Substance;Polystyrenes;Population;prevent;Production;Protocols documentation;Proxy;receptor;reduced food intake;Regulation;Reporter;response;RNA Interference;Role;Sensory;sensory system;Signal Pathway;Signal Transduction;Signaling Molecule;Smell Perception;Testing;time use;Tissues;Touch sensation;transmission process;Tyramine;tyramine receptor;Visualization;Work

PROJECT_TITLE: Determining the neural mechanisms of mechanosensory food perception in DR-mediated longevity


ADMINISTERING_IC: AR

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Aging;Arthritis;Bioengineering;Chronic Pain;Clinical Research;Nanotechnology;Osteoarthritis;Pain Research;Physical Injury - Accidents and Adverse Effects

ORG_CITY: GAINESVILLE

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: PROJECT NARRATIVE Osteoarthritis (OA), the leading cause of disability in the United States, has no effective therapy to slow or prevent disease progression. Oxidative stress plays a central role in the development of OA, however attempts to mitigate oxidative stress with antioxidants have been limited by poor bioavailability and limited stability within the joint. Thus, the objective of this proposal is to utilize a cartilage-targeting nanomaterial with antioxidant-like properties that overcomes limitations of conventional therapies to effectively mitigate oxidative stress, thereby reducing damage to joint structure and preserving joint function in post traumatic OA.

PI_NAMEs: ALDRICH, JESSICA L (contact)

PROGRAM_OFFICER_NAME: PINTUCCI, GIUSEPPE

PROJECT_TERMS: Address;Advanced Development;Affect;aging population;antioxidant therapy;Antioxidants;Arthralgia;arthropathies;Behavior;Binding Sites;Biocompatible Materials;Biological Availability;Biological Factors;Cartilage;cartilage degradation;catalase;Characteristics;Charge;Chondrocytes;chondroprotection;Chronic;Classification;Clinic;Contralateral;conventional therapy;cost;Degenerative polyarthritis;Development;disability;Disease;Disease Progression;Drug Delivery Systems;effective therapy;Engineering;Enzymes;Etiology;Evaluation;Feedback;gait examination;Generations;Histologic;Homeostasis;Hydrogen Peroxide;improved;In Vitro;in vivo;Inflammation;Inflammatory;inflammatory marker;injured;Injury;innovation;insight;Interruption;joint destruction;joint function;joint injury;Joints;Knee Injuries;Laboratory Research;Learning;Limb structure;Location;Manganese;Masks;Measures;metal oxide;Mitochondria;mitochondrial dysfunction;Modeling;Motivation;nanomaterials;nanoparticle;nanoparticle delivery;novel;Orthopedics;Oxidation-Reduction;Oxidative Stress;Oxygen;Pain;Pathogenesis;Pathology;Peroxidases;Persons;Play;preservation;prevent;Production;Property;Public Health;Reactive Oxygen Species;Research;Rodent;Rodent Model;Role;sensor;Signal Transduction;small molecule;Structure;Superoxides;Tactile;targeted treatment;Techniques;Testing;Therapeutic;Therapeutic Agents;therapeutic target;Time;Training;training opportunity;Translating;translational approach;translational medicine;translational potential;Traumatic Arthropathy;Treatment Efficacy;United States;uptake;Water;Work

PROJECT_TITLE: Manganese dioxide as a nanozyme to mitigate oxidative stress in osteoarthritis


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Prevention;Substance Misuse

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Advisory Committees;Animals;Annual Reports;Award;Behavioral Sciences;Budgets;Cities;Clinical;Collaborations;Communication;Communities;community advisory board;community partners;Complex;Dedications;Development;District of Columbia;Ensure;Epidemic;Event;Funding;Government;Grant;Guidelines;Health;HIV;innovation;Institution;Institutional Review Boards;Interest Group;Lead;Leadership;meetings;Modeling;multidisciplinary;Newsletter;next generation;Policies;Prevention;Procedures;Process;Production;programs;recruit;Research;Research Personnel;Research Support;Resources;Science;Secure;Services;Social Sciences;Strategic Planning;Translational Research;United States National Institutes of Health;Update;Wages;Washington;web site;working group

PROJECT_TITLE: Administrative Core


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Aging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Colorectal Cancer;Comparative Effectiveness Research;Diabetes;Digestive Diseases;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: Newark

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: PUBLIC HEALTH RELEVANCE Patients with diabetes diagnosed with colorectal cancer are at high risk for excess morbidity and mortality and are disproportionately Non-Hispanic Black and Hispanic. Federally qualified health centers, who primarily serve priority populations, struggle to implement and sustain colorectal cancer screening. This study proposes to identify and overcome multi-level factors affecting optimal use of CRC preventive screening options for patients with elevated medical and social risks throughout the U.S.

PI_NAMEs: O'MALLEY, DENALEE M. (contact)

PROGRAM_OFFICER_NAME: RANDHAWA, GURVANEET

PROJECT_TERMS: acceptability and feasibility;Adherence;Affect;Black Populations;Black race;cancer health disparity;Cancer Patient;cancer prevention;Career Mobility;Caring;Chronically Ill;Clinic;clinical research site;colon cancer patients;Colonoscopy;Colorectal Cancer;colorectal cancer prevention;colorectal cancer screening;Communities;community based participatory research;comorbidity;Comprehensive Health Care;Data;Development;Diabetes Mellitus;Diagnosis;Effectiveness;effectiveness evaluation;effectiveness-implementation RCT;effectiveness/implementation hybrid;Environment;ethnic difference;ethnic disparity;ethnic minority;Evaluation;Exploration, Preparation, Implementation, and Sustainment;Failure;Federally Qualified Health Center;Future;glycemic control;Goals;hands-on learning;health disparity;Health Expenditures;high risk;Hispanic;implementation barriers;implementation evaluation;implementation science;implementation strategy;implementation tool;improved;Individual;Intervention;Interview;Leadership;Low income;Malignant Neoplasms;Maps;Measures;Medical;Mentors;Methods;Modeling;Morbidity - disease rate;mortality;Not Hispanic or Latino;Participant;Patients;Phase;Population;Practice based research;practice-based research network;Preparation;Prevention strategy;Preventive;Preventive screening;Primary Care;primary care patient;primary care setting;process improvement;programs;Provider;public health relevance;racial difference;racial disparity;racial minority;recruit;Regression Analysis;Research;Research Methodology;Resources;Risk;safety net;screening;Screening for cancer;Screening procedure;screening program;social;Source;Structure;Surveys;Testing;theories;Training;Translating;uptake;years of life lost

PROJECT_TITLE: Optimizing Colorectal Cancer Screening among Patients with Diabetes in Safety-Net Primary Care Settings: Targeting Implementation Approaches

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Transition to Independence Study Section (I)[NCI-I]


NIH_SPENDING_CATS: Genetics

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

ORG_STATE: CA

PHR: Wnt signaling is conserved across animals and plays a role in many different developmental processes and diseases, which requires that the same signal activates different sets of genes in different contexts. It is largely unknown how it is possible for a single signal to have different effects and whether these mechanisms are conserved across species and during disease. In this study, I aim to identify the regulatory mechanism that impact the output of Wnt signaling using Hydra vulgaris, which offers the advantage of a simplified system for addressing a complex question.

PI_NAMEs: MORRIS LITTLE, HANNAH  (contact)

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TERMS: Address;Adult;Animals;ATAC-seq;Atlases;beta catenin;Binding;cell type;Cells;ChIP-seq;Cnidaria;combinatorial;Complex;Data;Development;Developmental Biology;developmental disease;Developmental Gene;Developmental Process;directed differentiation;Disease;Ectoderm;Endoderm;Epithelial Cells;experimental study;Gene Expression;gene regulatory network;Genes;Genetic Transcription;Goals;Head;Homeobox;knock-down;Ligands;Malignant Neoplasms;Mediating;Modeling;Molecular;Morphology;Mus;Oral;oral cavity epithelium;Organism;Outcome;Output;Pathway interactions;Pattern;Proteins;Regulation;Resolution;response;RNA Interference;Role;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Sorting;Specific qualifier value;System;Testing;transcription factor;Transcriptional Activation;transcriptome sequencing;WNT Signaling Pathway;Work

PROJECT_TITLE: Solving cell-type specific differences of the Wnt-directed gene regulatory network in Hydra vulgaris.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-Q(20)L]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: BOSTON

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

ORG_STATE: MA

PHR: Project Narrative As antibiotic resistance continues to remain a growing global health concern, it is vital that novel targets for bacterial antibiotics are identified. Bacterial cell-wall glycoconjugates are central to virulence and bacterial viability and are constructed sequentially by glycosyltransferases (GTs). The outcomes of the proposed project will deepen our understanding of the modes of action of GTs in the biosynthetic pathway of glycoconjugates, providing the necessary structural and biochemical information for new therapeutics.

PI_NAMEs: KNOX, HAYLEY  (contact)

PROGRAM_OFFICER_NAME: JONES, LATAISIA CHERIE

PROJECT_TERMS: Acceleration;Active Sites;Anabolism;Antibiotic Resistance;Antibiotics;Bacteria;Bacterial Antibiotic Resistance;Binding;Binding Sites;Biochemical;Bioinformatics;Biological Assay;C-terminal;Campylobacter;Categories;Cations;Cell Wall;Chemical Agents;Chimeric Proteins;Classification;Complex;Cryoelectron Microscopy;Deltaproteobacteria;design;Development;dimer;Divalent Cations;Environment;enzyme activity;Enzyme Interaction;Enzyme Kinetics;Enzymes;Epsilonproteobacteria;experimental study;Family;global health;Glycoconjugates;glycosylation;glycosyltransferase;inhibitor;inorganic phosphate;Kinetics;Knowledge;Life;Link;link protein;Lipids;Location;macromolecule;maleic acid;Maps;Mediating;Membrane;Metals;Methodology;Molecular;Multiprotein Complexes;Mutagenesis;N-terminal;nano;novel;novel strategies;novel therapeutics;Orthologous Gene;Outcome;particle;pathogen;pathogenic bacteria;Pathogenicity;Pathway interactions;Play;Polysaccharides;Positioning Attribute;protein complex;Protein Glycosylation;Proteins;Reaction;Resistance;Roentgen Rays;Role;Scanning;screening;Screening Result;Shapes;Specificity;Structure;Structure-Activity Relationship;Styrenes;sugar;Therapeutic;Virulence;Work;X-Ray Crystallography

PROJECT_TITLE: Defining structure and function of GT-A fold enzymes in bacterial glycan assembly


NIH_SPENDING_CATS: Clinical Research;Estrogen;Neurosciences;Women's Health Research

ORG_CITY: CHICAGO

ORG_DEPT: PHYSICAL MEDICINE & REHAB

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative The study proposed in this application exhibits substantial promise to quantify motoneuron physiology in the underrepresented population of females and identify a mechanism behind sex differences in motoneuron discharge. Additionally, this is the first quantitative study to examine motoneuron discharge properties across the menstrual cycle. The proposed paradigm is positioned to increase knowledge on female motoneuron physiology, and aid in the understanding of what causes sex differences in the progression of neurological disease.

PI_NAMEs: JENZ, SOPHIA THERESA (contact)

PROGRAM_OFFICER_NAME: KIM, JENNY LILY

PROJECT_TERMS: Address;Animals;Ankle;Biological;biophysical properties;Brain region;Brain Stem;Cell Nucleus;Cognition;Contraceptive methods;Disease;Electromyography;Emotions;Equity;Esthesia;Estradiol;Estradiol Receptors;Estrogens;Exclusion;Exhibits;Fatigue;Female;Gonadal Steroid Hormones;Health;Hormonal;Hormones;Human;Human body;Individual;insight;Isometric Contraction;Knowledge;Luteal Phase;male;Mediating;Menstrual cycle;Menstruation;Methods;monoamine;Motor;motor control;Motor Neurons;Movement;Muscle Fibers;Nervous System;Nervous System Disorder;Nervous System Physiology;neuromuscular;Neurons;neurophysiology;neuroregulation;Neurosciences;Norepinephrine;Oral;Oral Contraceptives;Output;Pain;Participant;Pattern;Performance;Physiological;Physiology;Positioning Attribute;Process;Progesterone;Progesterone Receptors;Progestins;Property;Research;Resistance;Serotonin;sex;sex cycle;Sex Differences;Signal Transduction;Spinal Cord;Surface;System;Testing;Time;Underrepresented Populations;women versus men;Women's study;Work;young adult

PROJECT_TITLE: Identifying mechanisms underlying sex differences in motoneuron discharge


NIH_SPENDING_CATS: Attention Deficit Hyperactivity Disorder (ADHD);Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Networking and Information Technology R&D (NITRD);Pediatric;Rehabilitation

ORG_CITY: PISCATAWAY

ORG_DEPT: PSYCHOLOGY

ORG_NAME: RUTGERS, THE STATE UNIV OF N.J.

PHR: Project Narrative Virtual reality can provide a distraction free and engaging environment and automate point-of-performance monitoring and feedback of concentration and focus. Virtual reality may provide a novel way to provide high impact behavioral treatment to address the significant difficulties with attention, motivation and work efficiency experienced by individuals with attention deficit hyperactivity disorder.

PI_NAMEs: LANGBERG, JOSHUA MORRIS (contact);SHEPHERD, DAVID CARROLL

PROGRAM_OFFICER_NAME: PUGLIESE, CARA ELISABETH

PROJECT_TERMS: Address;Adherence;Adult;Algorithms;Attention;Attention deficit hyperactivity disorder;Behavior;Behavior Therapy;Behavioral;Behavioral Mechanisms;Clinical Psychology;cognitive training;college;computer science;Computer software;contingency management;Data;Development;Disease;distraction;Dose;efficacy evaluation;emerging adult;Engineering;Engineering Psychology;Environment;Evaluation;evidence base;Executive Dysfunction;experience;Eye;Feedback;Focus Groups;follow-up;gaze;Goals;health equity;Impairment;improved;Individual;Interruption;Intervention;invention;laptop;Libraries;Light;Measures;Mediation;Mediator;Mental Health;Monitor;Motivation;Mus;novel;Parents;Participant;Performance;Pharmaceutical Preparations;Phase;pilot test;Practice Guidelines;Productivity;professional atmosphere;Protocols documentation;Psychological reinforcement;Randomized;randomized trial;Randomized, Controlled Trials;Reading;Recommendation;Research Personnel;Resolution;Resources;Rewards;Structure;Students;support tools;Surveys;Symptoms;teacher;Techniques;Technology;Testing;Time;tool;Traction;Treatment Efficacy;Universities;university student;usability;virtual reality;virtual reality environment;virtual reality headset;virtual reality intervention;virtual world;Visual;ward;Work;Writing

PROJECT_TITLE: Development of a Novel Virtual Reality Treatment for Emerging Adults with ADHD


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Prevention;Substance Misuse

PI_NAMEs: BUKRINSKY, MICHAEL ILYA (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Applications Grants;Award;Cities;Collaborations;Communities;community advisory board;Complement;Data;Development;Discipline;District of Columbia;driving force;Education;Educational workshop;Epidemic;experience;Faculty;Funding;Goals;Government;Grant;HIV;innovation;Institution;Investments;Journals;Left;meetings;member;Mentors;Mission;multidisciplinary;next generation;outreach program;programs;Research;Research Personnel;Research Project Grants;Research Support;Resources;Series;service utilization;Services;Silver;skills;Training;Training and Education;Training Programs;Underrepresented Minority;United States National Institutes of Health;Universities;Washington;webinar;Woman;Writing

PROJECT_TITLE: Developmental Core


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Drug Abuse (NIDA only);Genetics;HIV/AIDS;Human Genome;Infectious Diseases;Prevention;Substance Misuse

PI_NAMEs: MAGGIRWAR, SANJAY B. (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Animal Model;Antibodies;Applications Grants;assay development;Award;Basic Science;Binding;Biological Assay;Budgets;Cells;Clinical Investigator;Collaborations;Collection;Computer software;Confocal Microscopy;Consult;Consultations;cost;Data;Department chair;Development;District of Columbia;DNA sequencing;Drug Modelings;Drug Screening;Education and Outreach;Equipment;Event;Flow Cytometry;Fostering;Functional Imaging;Funding;Genomics;HIV;Image;Image Analysis;image reconstruction;Immunologics;Immunology;Immunology procedure;in silico;Individual;innovation;Institution;instrument;Interdisciplinary Study;investigator training;Investments;Jordan;Laboratories;Laboratory Scientists;Laboratory Technicians;Leadership;Maintenance;Mass Spectrum Analysis;Mentors;Methods;Microbiology;microscopic imaging;Microscopy;minority investigator;Mission;Molecular;molecular imaging;new technology;next generation sequencing;novel;outreach;programs;protein expression;protein purification;Proteins;Proteomics;Protocols documentation;Proxy;Reagent;recruit;Research;research and development;Research Personnel;Resources;RNA analysis;Scientist;Senior Scientist;Series;service providers;Service provision;Services;single cell analysis;single cell sequencing;small molecule;Suggestion;Surface Plasmon Resonance;System;Techniques;Technology;Tissues;Training;Training Programs;transcriptome sequencing;translational scientist;Transmission Electron Microscopy;Tropical Medicine;Underrepresented Minority;United States National Institutes of Health;Universities;Update;viral detection;virology;Wages;Washington;Woman;Work

PROJECT_TITLE: Basic Sciences Core


PI_NAMEs: MAGNUS, MANYA  (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Administrative Supplement;AIDS prevention;Applications Grants;Award;biobank;Biological;Biometry;Caring;Clinic;Clinical;Clinical Research;Clinical Sciences;clinical training;Clinics and Hospitals;cohort;Cohort Studies;Communities;Consultations;Data;Data Analyses;Database Management Systems;Development;Discipline;District of Columbia;Epidemic;Epidemiology;epidemiology study;Ethics;experience;Funding;Government;Grant;Grant Review;HIV;improved;innovation;Institution;Leadership;Left;Manuscripts;member;Mission;novel strategies;Patients;Persons;Population;Population Sciences;Population Study;Positioning Attribute;pre-exposure prophylaxis;Prevention;Printing;Procedures;programs;Protocols documentation;Public Health;Publications;recruit;Research;Research Design;Research Methodology;Research Personnel;Research Priority;Research Support;Resources;Risk;Sample Size;Science;Scientist;Series;service providers;Services;Specimen;Statistical Data Interpretation;United States National Institutes of Health;Washington

PROJECT_TITLE: Clinical and Population Sciences Core


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: CHARLESTON

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: Sterile processing departments (SPDs) clean and repack reusable surgical instruments. Unfortunately, about 15% of surgical instrument trays have problems that can lead to a range of safety and efficiency problems. We propose to extend our previous Work Systems Analysis to develop interventions, improve data-analytic approaches, and study administrative decision making, across multiple SPD facilities.

PI_NAMEs: CATCHPOLE, KEN  (contact);RAYO, MICHAEL F.

PROGRAM_OFFICER_NAME: MILLER, MELISSA

PROJECT_TITLE: System Optimization for Advances in Sterile Processing

STUDY_SECTION: HSVR

STUDY_SECTION_NAME: Healthcare Systems and Values Research[HSVR]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

PI_NAMEs: KERRIGAN, DEANNA L (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;AIDS prevention;Applications Grants;Applied Research;Area;Back;Basic Science;Behavior;Behavioral;Behavioral Research;Behavioral Sciences;Bisexual;Black race;Caring;cis-female;Clinical;Clinical Trials;Coffee;Collaborations;Communities;community engaged research;community partners;condoms;Consultations;Databases;Development;Discipline;District of Columbia;Education;Educational workshop;Ensure;Epidemic;ethnic minority population;Event;Focus Groups;Funding;Gays;Goals;health inequalities;Heterosexuals;HIV;HIV diagnosis;Hour;improved;Incidence;Individual;Inequity;Information Dissemination;Infrastructure;innovation;insight;Institution;Institutionalization;Intervention;Latina;Latino;Link;Local Government;Measures;meetings;member;men who have sex with men;Methodology;Methods;metropolitan;Mission;Newly Diagnosed;Peer Group;Peer Review Grants;Persons;Population;pre-exposure prophylaxis;Prevention;Prevention Research;Public Health;racial minority population;Research;Research Design;Research Personnel;Research Priority;Research Project Grants;Resources;Science;Scientist;Service provision;Services;social;Social Sciences;social structure;sociodemographics;Technology;theories;Training;transgender women;Treatment outcome;treatment research;trend;virtual;Washington;Woman;working group

PROJECT_TITLE: Social and Behavioral Sciences Core


PI_NAMEs: LYNCH, REBECCA MARIE (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;antibody immunotherapy;Applications Grants;Area;Attitude;Award;Cell Therapy;collaboratory;Communities;community based research;community engagement;community partners;Development;District of Columbia;Epidemiologist;Ethical Issues;Foundations;Funding;Government;Group Meetings;HIV;innovation;Institution;Knowledge;Laboratory Scientists;Leadership;Manuscripts;Measures;meetings;member;Monitor;outreach;Perception;Publications;Publishing;reconstitution;recruit;Research;Research Personnel;Resources;Scientist;Services;Underrepresented Minority;United States National Institutes of Health;Universities;Washington;Woman;Work;working group

PROJECT_TITLE: HIV Cure Scientific Working Group


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Dissemination and Implementation Research;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Prevention;Substance Misuse

PI_NAMEs: CASTEL, AMANDA DERRYCK (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;aged;Baltimore;Caring;Cities;Communities;community engagement;community partnership;Complement;County;Development;Diagnosis;District of Columbia;Epidemic;follow-up;Funding;Government;health data;high risk;HIV;HIV diagnosis;implementation science;innovation;Institution;Internet;Local Government;Maryland;men who have sex with men;Mid-Atlantic Region;minority investigator;Mission;Modeling;Newly Diagnosed;NIH Program Announcements;pre-exposure prophylaxis;prevent;programs;Public Health;Puerto Rico;Research;Research Personnel;Research Support;response;scale up;Science;Underrepresented Minority;United States;United States Health Resources and Services Administration;United States National Institutes of Health;Viral;Washington;Woman;working group;Youth

PROJECT_TITLE: Ending the HIV Epidemic Scientific Working Group


NIH_SPENDING_CATS: Cardiovascular;Genetics;Human Genome;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

PHR: PROJECT NARRATIVE/PUBLIC HEALTH RELEVANCE Perivascular fibrosis, which is the progressive accumulation of non-cellular extracellular matrix, decreases normal vascular function and increases vessel stiffness. The studies in this proposal focus on the contribution of a unique population of resident vascular stem cells in the development of fibrosis as these cells lose their stemness phenotype and switch to a phenotype for producing matrix in the setting of vascular disease. We aim to define the mechanisms that control the phenotype of these vascular stem cells in the setting of vascular disease, to define the response to vascular injury and the role of these stem cells in a novel adult mouse model that demonstrates remarkable wound healing without fibrosis, and to define the anti-fibrotic effect of statins using cultured cells and mouse models of vascular fibrosis, which will lead to highly translatable findings that guide the clinical application of statins in the treatment and prevention of fibrotic diseases.

PI_NAMEs: MAJESKY, MARK W.;WEISER-EVANS, MARY CM (contact)

PROGRAM_OFFICER_NAME: CATANIA, SELEN MURATOGLU

PROJECT_TERMS: Acomys;Acute;Adult;Atherosclerosis;Blood Vessels;Cell Differentiation process;Cell Maintenance;Cell model;Cell Reprogramming;Cells;Chronic;clinical application;cohort;Coronary artery;Cultured Cells;Cytometry;Databases;Deposition;Development;Disease;Epigenetic Process;Extracellular Matrix;Extracellular Matrix Proteins;Fibrosis;Gene Expression Profile;Genes;Genetic;genetic signature;HDAC1 gene;Human;Immune;In Situ;In Vitro;Inflammation;Injury to Kidney;Knock-out;Maintenance;Mammals;Maps;Mesenchymal;Modeling;Molecular;mouse model;Mus;Myofibroblast;Natural regeneration;Normal tissue morphology;novel;overexpression;Pathologic;Pathway interactions;Patients;Perivascular Fibrosis;Phenotype;Play;Population;Prevention;Process;Profibrotic signal;progenitor;Proteins;Proteome;Proteomics;public health relevance;regenerative;Regenerative wound healing;Regulation;Reporter;Reporting;Repression;Resistance;response;RNA;Rodent;Role;Signal Transduction;single-cell RNA sequencing;Smooth Muscle Myocytes;Source;stem cells;stemness;System;Therapeutic Studies;tissue repair;Tissues;Transcript;transcription factor;transcriptome sequencing;transcriptomics;Tunica Adventitia;Validation;Vascular Diseases;vascular injury;Vascular remodeling;Vascular Smooth Muscle;wound healing

PROJECT_TITLE: Reprogramming of mature SMCs to vascular progenitor cells: Focus on Vascular Fibrosis

STUDY_SECTION: BBHV

STUDY_SECTION_NAME: Basic Biology of Blood, Heart and Vasculature Study Section [BBHV]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Infectious Diseases;Neurodegenerative;Neurosciences;Sexually Transmitted Infections;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: SYRACUSE

ORG_NAME: UPSTATE MEDICAL UNIVERSITY

ORG_STATE: NY

PHR: Project Narrative: Human neurotropic herpesviruses are linked to poor outcomes in Alzheimer's Disease patients. However, a direct link between neurodegenerative alterations and viral infections remains uncharacterized. In this proposed work, we will extend our exciting findings of infection-dependent alterations in drivers of Alzheimer's Disease in a novel 3D cerebral cortical human cell model. Characterization of the biological mechanisms controlled by these viruses will represent a major advance in efforts to combat this disease.

PI_NAMEs: MURPHY, EAIN A (contact)

PROGRAM_OFFICER_NAME: MARIC, MAJA

PROJECT_TERMS: abeta accumulation;Alleles;Alternative Splicing;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease risk;Amyloid beta-42;Amyloid beta-Protein Precursor;amyloid precursor protein processing;apolipoprotein E-3;apolipoprotein E-4;Arginine;Automobile Driving;Biological;Biological Models;cell cortex;Cell model;Cells;Cerebral cortex;Cerebrum;Clinical;clinically relevant;Cognitive;combat;Coupled;Data;Dementia;Disease;Disease Marker;Disease Progression;DNA;established cell line;Etiology;Exclusion;Exons;Frequencies;gene correction;Genes;Genetic;genetic risk factor;Genetic Transcription;Goals;Herpes Simplex Infections;Herpesviridae;Herpesviridae Infections;Herpesvirus 1;HHV-6A;Human;human induced pluripotent stem cells;hyperphosphorylated tau;Impaired cognition;Individual;induced pluripotent stem cell;Infection;insight;Integration Host Factors;Interdisciplinary Study;Investigation;Kinetics;Label;latent infection;Link;Lytic;Messenger RNA;Modeling;Monitor;mRNA Precursor;Mutation;Nerve Degeneration;nervous system infection;neural;Neurodegenerative Disorders;Neuroglia;Neurons;neurotropic;neurotropic virus;new therapeutic target;Normal tissue morphology;novel;Organoids;Outcome;pathogen;Pathogenesis;pathogenic virus;Pathogenicity;Pathology;patient derived induced pluripotent stem cells;Patients;permissiveness;Physiological;Population;Post-Translational Protein Processing;Predisposition;Production;Protein Isoforms;Protein Kinase;Proteins;Protocols documentation;Reporter;Resolution;Risk;RNA;RNA Splicing;Running;Serine;Severities;single cell sequencing;spatial relationship;Spices;stem cell organoids;Synapses;System;tau aggregation;tau expression;tau Proteins;tau-1;Tauopathies;Techniques;Testing;Time;Tissues;Transcript;transcriptome;Tropism;Uracil phosphoribosyltransferase;Viral;Viral Pathogenesis;Virus;Virus Diseases;Work

PROJECT_TITLE: Alzheimer's Disease associated pathology induced by neurotropic viral infection


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Complementary and Integrative Health;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Physical Injury - Accidents and Adverse Effects;Post-Traumatic Stress Disorder (PTSD);Prevention;Rehabilitation;Substance Misuse

ORG_CITY: SEATTLE

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE The co-occurrence of posttraumatic stress disorder (PTSD) and hazardous drinking (HD) can be particularly devastating; though evidence-based treatments exist, many individuals with this co-occurrence drop out from or do not or cannot access specialty care. Text-messaging is a mode of intervention delivery that is low-cost, low-burden, and accessible to most people; development and testing of self-directed text message interventions that use evidence- and theoretically-based strategies to reduce PTSD and HD symptom burden is highly needed. Such interventions have the potential for great clinical significance via providing additional, novel treatment options that are readily scalable and have wide reach and thus can have a large impact on individual and public health.

PI_NAMEs: BEDARD-GILLIGAN, MICHELE A;LINDGREN, KRISTEN P (contact)

PROGRAM_OFFICER_NAME: ROACH, DEIDRA

PROJECT_TERMS: Address;Adult;Alcohol consumption;alcohol related consequences;alcohol use disorder;avoidance behavior;Basic Science;behavior change;Behavior Therapy;Behavioral;Behavioral Research;brief intervention;Caring;clinically significant;cognitive enhancement;Cognitive Science;Cognitive Therapy;Communities;comparative;comparative efficacy;Complex;coping;cost;Data;Decision Making;design;Development;Disease;drinking;Dropout;Drops;efficacious intervention;efficacy testing;Employment;Ethnic Origin;Evaluation;Event;evidence base;Evidence based treatment;Feedback;follow-up;Future;Gender;General Population;Growth;hazardous drinking;Health Services Accessibility;Heavy Drinking;Individual;innovation;Intervention;intervention delivery;intervention refinement;Intervention Studies;Legal;Literature;mass casualty;medical specialties;mobile application;Motivation;National Institute on Alcohol Abuse and Alcoholism;Natural Disasters;novel;Outcome;pandemic disease;Participant;Persons;Phase;Pilot Projects;portability;Post-Traumatic Stress Disorders;Poverty;primary outcome;psychologic;Public Health;Randomized, Controlled Trials;recruit;reduce symptoms;Reporting;Research;response;revictimization;Sampling;Self Direction;Severities;skills;Social Psychology;social stigma;societal costs;Strategic Planning;Structure;suicidal behavior;Symptom Burden;Symptoms;Techniques;Technology;Testing;Text Messaging;text messaging intervention;theories;Trauma;trauma exposure;Treatment Efficacy;Veterans;web app

PROJECT_TITLE: Testing the efficacy of a CBT-enhanced text message intervention to reduce symptom burden in individuals with post-traumatic stress disorder symptoms and co-occurring hazardous drinking

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]