NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Colorectal Cancer;Digestive Diseases;Genetics;Human Genome;Immunotherapy;Machine Learning and Artificial Intelligence;Orphan Drug;Precision Medicine;Radiation Oncology;Rare Diseases

PHR: Project Narrative Developing optimal radiation and immunotherapy combinations is hindered by the limited ability to deeply understand therapeutic responses and there is a critical need to innovate with rectal cancer when cure with radiation and systemic therapy could save a morbid surgery. We have developed an integrated approach to assess early biopsy tissue after short course radiation therapy to assess molecular, cellular, and spatial dynamics that could improve our ability to nominate promising therapies. With pre- and post- therapy biopsies from our αCD40 trial, we will perform single cell RNA sequencing, multiplexed immunofluorescence, deep learning from histopathologic tissue to identify therapeutic opportunities and study mechanisms of response to αCD40.

PI_NAMEs: AGUILERA, TODD A (contact)

PROGRAM_OFFICER_NAME: SOMMERS, CONNIE L

PROJECT_TERMS: Acceleration;adaptive immune response;Agonist;Animal Model;anti-tumor immune response;Antibodies;Biopsy;cancer immunotherapy;chemotherapy;Chemotherapy and/or radiation;Clinical;Clinical assessments;Clinical Trials;Colorectal Cancer;Combination immunotherapy;Complex;Coupled;curative treatments;Data Set;deep learning;Dendritic Cells;Development;Disease Management;efficacy testing;enhancing factor;Evaluation;Event;evidence base;Experimental Models;Future;high risk;Histologic;Human;Immune;Immune response;Immune signaling;Immune Targeting;Immunofluorescence Immunologic;immunogenic;Immunotherapy;immunotherapy trials;improved;improved outcome;In complete remission;Incidence;Individual;Innate Immune Response;innovation;insight;Knowledge;Learning;Local Therapy;Malignant Neoplasms;Maps;Mismatch Repair Deficiency;Modeling;Molecular;Neighborhoods;Neoadjuvant Therapy;novel;Operative Surgical Procedures;participant enrollment;Pathway interactions;patient population;patient response;Patient Selection;Patients;permissiveness;personalized medicine;Pharmacodynamics;Phase;phase II trial;Population;precision oncology;Proteomics;Radiation;radiation response;Radiation therapy;randomized trial;randomized, clinical trials;receptor;Rectal Cancer;responders and non-responders;response;Risk Reduction;Signal Transduction;single-cell RNA sequencing;success;synergism;Systemic Therapy;Technology;Therapeutic;Therapeutic Effect;therapy development;Tissues;TNFRSF5 gene;treatment response;trial design;tumor;tumor microenvironment;Tumor Tissue;Validation

PROJECT_TITLE: Early response to radiotherapy and immunotherapy in rectal cancer: an integrated molecular, cellular, and spatial approach


ADMINISTERING_IC: DK

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences;Nutrition;Obesity;Prevention

ORG_CITY: PHILADELPHIA

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: MONELL CHEMICAL SENSES CENTER

ORG_STATE: PA

PHR: PROJECT NARRATIVE The drive to eat is mediated by activity in homeostatic (i.e., nutrient need, hunger) and hedonic (i.e., pleasure, reward) neural circuits in the brain. In our modern food environment, this drive to eat has led to an obesity crisis, especially in the United States. The current proposal takes a unique approach to understanding obesity by (1) determining how homeostatic and hedonic circuits interact to promote overeating and (2) revealing how neural activity in these circuits predicts future development of obesity, potentially leading to paradigm-shifting prevention and treatment strategies for obesity.

PI_NAMEs: ALHADEFF, AMBER L (contact)

PROGRAM_OFFICER_NAME: CUMMINGS, DIANA M

PROJECT_TERMS: Adult;Anatomy;ART protein;Biological Markers;Body Weight decreased;Brain;Brain region;cell type;cellular targeting;Corpus striatum structure;Development;Diet;diet-induced obesity;Dopamine;dopaminergic neuron;Dorsal;Eating;experimental study;Fatty acid glycerol esters;feeding;Feeding behaviors;Food;food environment;Future;Genetic;genetic technology;hedonic;Hunger;Hyperphagia;Hypothalamic structure;in vivo;Individual;Individual Differences;Intake;Lateral;Link;Mediating;Midbrain structure;Modernization;Molecular Target;Monitor;mouse model;Mus;neural;neural circuit;neural correlate;Neurons;Neurotransmitters;novel strategies;Nutrient;Obesity;obesity development;obesity prevention;obesity treatment;obesogenic;optogenetics;Pathologic;Pattern;Persons;pharmacologic;Pilot Projects;pleasure;Predisposition;Prevalence;Prevention strategy;Public Health;response;Rewards;Rodent Model;Role;Signal Transduction;Signaling Protein;Site;sugar;System;Testing;Thinness;Time;treatment strategy;United States;Ventral Striatum;Weight Gain;Work

PROJECT_TITLE: Unraveling the homeostatic and hedonic circuits underlying feeding behavior and obesity

STUDY_SECTION: POMD

STUDY_SECTION_NAME: Pathophysiology of Obesity and Metabolic Disease Study Section[POMD]


ADMINISTERING_IC: AR

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Bioengineering;Biotechnology

ORG_CITY: BOSTON

ORG_DEPT: CHEMISTRY

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

ORG_STATE: MA

PHR: PROJECT NARRATIVE To advance drug delivery in line with the rapid development of targeted biotherapeutics, it is necessary to create new systems that simultaneously deliver a payload and amplify its efficacy. Here, we propose a method to deliver, localize, and enhance the antifibrotic effects of relaxin-2, a therapeutic which showed varied pre-clinical and clinical efficacy, to demonstrate the power of tailored drug delivery systems to potentiate biotherapeutics through receptor upregulation.

PI_NAMEs: GRINSTAFF, MARK W. (contact);KRUSE, ANDREW ;NAZARIAN, ARA

PROGRAM_OFFICER_NAME: WASHABAUGH, CHARLES H

PROJECT_TERMS: Acute;Address;Adverse event;Affect;Animals;antifibrotic treatment;Articular Range of Motion;biocompatible polymer;biodegradable polymer;Biological Markers;Biological Response Modifier Therapy;canine model;cartilaginous;Case Study;Cell Physiology;Characteristics;Chemosensitization;Chondrocytes;Clinical;clinical efficacy;clinical translation;Clinical Treatment;Clinical Trials;clinically relevant;Collaborations;Collagen;Contracture;coronary fibrosis;cost;Coupled;CRISPR/Cas technology;Cryoelectron Microscopy;crystallinity;Cutaneous;cytotoxicity;Data;density;design;Development;Dexamethasone;Disease;disease model;disease phenotype;Dose;Drug Administration Routes;Drug Delivery Systems;Drug Design;Drug Kinetics;Drug Modulation;Drug Receptors;Drug Targeting;Experimental Designs;experimental study;Extracellular Matrix Proteins;Fibroblasts;Formulation;frontier;G-Protein-Coupled Receptors;Half-Life;Heart failure;Histologic;Hormones;Human;improved;improved outcome;In Vitro;in vivo;Injections;insight;Intra-Articular Injections;joint stiffness;Joints;Kidney;Kinetics;knock-down;Ligand Binding;Ligands;Lung;Measures;Mechanics;member;Metalloproteases;Methodology;Methods;Modeling;Molecular;Molecular Mechanisms of Action;Molecular Weight;Motivation;Musculoskeletal;Neurology;novel;Oncology;particle;Particle Size;Pathway interactions;peptide hormone;Persons;Pharmaceutical Preparations;Polymers;preclinical efficacy;Pregnant Women;prevent;programs;Property;Proteins;rational design;receptor;receptor binding;receptor density;receptor expression;Receptor Up-Regulation;receptor upregulation;Recovery;Regulation;Relaxin;Reporting;Role;Safety;Saline;Serum;Shoulder;Signal Pathway;Signal Transduction;skin fibrosis;Small Interfering RNA;small molecule;Specificity;stem;Structure;Symptoms;Synovial Fluid;System;Systemic Scleroderma;targeted delivery;Testing;Therapeutic;Therapeutic Effect;Time;Tissues;Toxic effect;transcriptome sequencing;United States;Validation

PROJECT_TITLE: The Conundrum of Absentee Receptors: Efficacy Potentiation Through Drug-Receptor Modulation

STUDY_SECTION: GDD

STUDY_SECTION_NAME: Gene and Drug Delivery Systems Study Section[GDD]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: ANN ARBOR

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative The prokaryotic CRISPR-Cas immune systems counteract parasitic genetic elements, and have also provided a set of eukaryotic gene-editing tools that revolutionized the study and treatment of human genetic disease. In this proposal, we will uncover the molecule basis for CRISPR immune memory formation. This work will substantially advance our understanding of CRISPR biology, and help expand the spectrum of CRISPR-based technologies to benefit human health.

PI_NAMEs: ZHANG, YAN  (contact)

PROGRAM_OFFICER_NAME: CZAPLINSKI, KEVIN

PROJECT_TERMS: adaptive immunity;Address;Affect;Anti-sense RNA;Antibiotic Resistance;antimicrobial;Bacteria;Biochemical;Biology;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;cofactor;CRISPR interference;CRISPR/Cas technology;Devices;Disease;DNA;Enzymes;Escherichia coli;fighting;gene editing technology;Generations;Genes;Genetic;Genetic Diseases;genetic element;Genetic Engineering;Genome;Genomics;Health;Horizontal Gene Transfer;Human;Human Genetics;Immune system;Immunologic Memory;Integrase;Knowledge;Memory;memory process;Microbe;Mobile Genetic Elements;model organism;Molecular;Molecular Genetics;Neisseria meningitidis;novel;pathogen;pathogenic bacteria;Pathogenicity;Play;Proteins;Recording of previous events;Research;Research Design;Role;Site;System;Technology;trait;Work

PROJECT_TITLE: Generation of DNA memory by bacterial CRISPR-Cas9 systems

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-D(55)R]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Dementia;Lymphatic Research;Neurodegenerative;Neurosciences

ORG_CITY: CINCINNATI

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF CINCINNATI

ORG_STATE: OH

PHR: The cerebrospinal fluid (CSF) and choroid plexus (CP) system conduct vital replenishment and surveillance for healthy brain functions. Abnormal CSF volumes are associated with different diseases including Alzheimer's disease (AD). The data gained in this research proposal will be directly applicable to understanding the underlying mechanisms of etiology for AD and future interventions to mitigate AD.

PI_NAMEs: LUO, YU  (contact)

PROGRAM_OFFICER_NAME: NEWMAN, ELIZABETH

PROJECT_TERMS: abeta accumulation;Ablation;Adult;adult neurogenesis;Affect;age acceleration;age related;age related neuroinflammation;Age-associated memory impairment;Aging;aging brain;aging population;aging process;Alleles;alpha synuclein;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease therapeutic;Amyloid beta-42;Amyloid beta-Protein;Amyloid Proteins;Animal Disease Models;Animal Model;Animals;Antibody Therapy;Apoptotic;Area;Astrocytes;Atrophic;Behavioral;Biology;Blood;Blood Vessels;Brain;Brain Diseases;brain health;Cataloging;Cause of Death;Cell Death;Cells;Central Nervous System Diseases;Cerebrospinal Fluid;Choroid Plexus Epithelium;Circulation;Cognitive;cognitive function;cytokine;Data;Development;Diphtheria Toxin;diphtheria toxin receptor;Disease;Disease Progression;Dose;Epithelial Cells;Etiology;extracellular;fluid flow;frontal lobe;functional outcomes;Future;glial activation;glymphatic clearance;glymphatic flow;glymphatic system;Goals;Health;Hippocampus;Homeostasis;Human;Immune;Impaired cognition;Impairment;in vivo;Induction of Apoptosis;Infiltration;Inflammation;Intervention;Intracranial Pressure;Investigation;juvenile animal;Knowledge;Link;Measures;Mediating;Metabolic;Modeling;Molecular;Motor;mouse model;Mus;Neonatal;Nerve Degeneration;Neurocognitive;neurocognitive test;neurogenesis;neuroinflammation;neuron loss;neuronal survival;Neurons;Neurosciences;normal aging;novel;novel therapeutic intervention;old mice;Outcome;Outcome Assessment;Pathogenesis;Pathologic;Pathology;Pathway interactions;Performance;Peripheral;Phenotype;Phosphorylation;Pilot Projects;Play;pre-formed fibril;Prevalence;Process;Production;Protein Isoforms;Proteins;Research Proposals;response;Rodent;Role;Senile Plaques;Severities;single nucleus RNA-sequencing;Structure of choroid plexus;Symptoms;Synapses;System;targeted treatment;tau aggregation;tau Proteins;Testing;Time;tool;Transgenic Mice;Transplantation;Ventricular;wasting;Work;β-amyloid burden

PROJECT_TITLE: Investigating the role of CSF production and circulation in aging and Alzheimer's disease

STUDY_SECTION: CDIN

STUDY_SECTION_NAME: Chronic Dysfunction and Integrative Neurodegeneration Study Section[CDIN]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Women's Health Research

ORG_CITY: Pittsburgh

ORG_NAME: MAGEE-WOMEN'S RES INST AND FOUNDATION

PHR: PROJECT NARRATIVE By age 80, 12.6% of women in the United States will have a surgery to repair pelvic organ prolapse (POP). Current POP repairs are performed using lightweight, wide, pored polypropylene meshes which can have complications. Here we propose to define mechanisms of complications to inform the use of current devices and the development of future novel devices for durable POP repair.

PI_NAMEs: ABRAMOWITCH, STEVEN D;MOALLI, PAMELA A. (contact)

PROGRAM_OFFICER_NAME: DEYAMPERT, TARA LYNN

PROJECT_TERMS: Address;Advocate;Age;Apoptosis;Area;Biocompatible Materials;Cells;Collagen;Complication;Computer Models;Data;Deposition;design;Deterioration;Development;Devices;Diamond;Disease;Disparate;Distant;Encapsulated;Epithelium;Event;Excision;Exposure to;Failure;Fiber;Fibroblasts;Fibrosis;functional outcomes;Future;Geometry;Grant;Immigration;Immune response;implantation;improved;In Vitro;in vitro Model;in vivo;Inflammatory;Injury;light weight;Macrophage;mechanical signal;Mechanical Stress;millimeter;Modeling;Modification;Molecular;Motion;Myofibroblast;nonhuman primate;novel;Operative Surgical Procedures;Oryctolagus cuniculus;Outcome;Pathologic;Pathway interactions;Patients;pelvic organ prolapse;Phenotype;Physiological;Polypropylenes;Process;Proliferating;repaired;Research;response;Role;Rotation;Signal Transduction;Site;Smooth Muscle;soft tissue;Stress;Surgeon;surgery outcome;Symptoms;Testing;Thinness;Time;tissue repair;Tissues;Translating;United States;Vagina;Variant;Woman

PROJECT_TITLE: Mesh complications: The role of local mechanical stresses on tissue remodeling following mesh implantation

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Narrative The Boston Older Americans Independence Center (Boston OAIC) has established a robust interdisciplinary research network among aging researchers from Boston's leading academic medical centers to foster translational research in function promoting therapies (FPTs) – pharmacologic, physical, nutritional, technological and behavioral interventions to reduce the burden of disabling functional limitations in older adults. The Boston OAIC will integrate 19 externally-funded studies, 3 Research Education Core projects, 3 pilot and exploratory science projects, and 3 developmental projects into an interdisciplinary program that is supported by a Leadership and Administrative Core, a Research Education Core, a Pilot and Exploratory Studies Core (PESC), and 3 research resource cores (Function Assessment Core, Preclinical Discovery Core, Biostatistics and Data Science Core). Unique strengths of OAIC include its focus on FPTs; emphasis on translation; demonstrable success in recruiting and advancing talented young investigators, especially physician scientists, including 3 Beeson scholars; its extension across the entire spectrum of translational research; the outstanding productivity of its investigators; strong leadership and institutional support; its success in developing intellectual property, leading and participating in some of the most important randomized trials of FPTs, and in forging synergistic collaborations with other OAICs and with other Boston area aging research programs.

PI_NAMEs: BHASIN, SHALENDER  (contact)

PROGRAM_OFFICER_NAME: SERRA, MONICA CHRISTINE

PROJECT_TERMS: Academic Medical Centers;Aging;American;Area;Award;Behavior Therapy;Behavioral;Biology of Aging;biomarker development;biomarker validation;Biometry;Boston;Capsicum;career;Clinical;clinical translation;Clinical Trials;Collaborations;commercialization;Communities;Core Facility;Data Science Core;Development;didactic education;Dietary Intervention;disability;Disabling;Doctor of Philosophy;Education;education research;efficacy trial;epidemiology study;Force of Gravity;forging;Fostering;Foundations;functional decline;functional outcomes;Funding;Future;Geriatrics;Gerontology;Grant;Growth;Human;improved;innovation;Institution;Intellectual Property;interdisciplinary collaboration;Interdisciplinary Study;invention;Investments;Leadership;Legal patent;Link;Medical center;Mentors;Muscle;New England;new technology;new therapeutic target;Nodal;novel;Nutritional;older adult;Outcome Measure;Patient Outcomes Assessments;Peer Review;pharmacologic;Physicians;Pilot Projects;Population;Positioning Attribute;pre-clinical;Process;Productivity;programs;Publications;randomized trial;recruit;Regulation;Research;Research Personnel;Research Training;Resources;response;Science;Scientist;Seminal;societal costs;success;Talents;Technology;technology intervention;Testing;Therapeutic Studies;therapeutic target;Training;Training Programs;Transcend;Translating;translational approach;translational pipeline;Translational Research;translational scientist;Translations;Treatment Efficacy;trend;United States National Institutes of Health;Universities;Update;Validation

PROJECT_TITLE: Boston OAIC: A Translational Approach to Function Promoting Therapies


NIH_SPENDING_CATS: Aging

PROJECT_TERMS: Academic Medical Centers;Accountability;Aging;American;Area;Behavior Therapy;Biology of Aging;Boston;Budgets;Capsicum;career;career development;Clinical;clinical translation;Collaborations;commercialization;Communities;Community Outreach;Core Facility;Development;Dietary Intervention;Directories;Disabling;Education;education research;experience;forging;Fostering;Foundations;Geriatrics;Gerontology;Goals;Grant;Information Dissemination;innovation;Institution;Interdisciplinary Study;Leadership;Logistics;Medical center;medical schools;meetings;member;Mentors;Monitor;New England;Newsletter;Nodal;older adult;operation;Peer Review;Personnel Management;pharmacologic;Productivity;Program Effectiveness;programs;Progress Reports;Reporting;Request for Applications;Research;Research Personnel;Research Support;Resources;Schedule;Science;Scientist;success;symposium;synergism;therapy development;Training;translational approach;Translational Research;Universities;Utilization Review;web site

PROJECT_TITLE: Leadership and Administrative Core


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Bioengineering;Dental, Oral, and Craniofacial Disease;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Temporomandibular Muscle/Joint Disorder (TMJD)

ORG_CITY: NEW YORK

ORG_DEPT: DENTISTRY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: Project narrative Temporomandibular joint disorders (TMJDs) affect over 10 million Americans, with 80 - 90% of TMJDs patients suffering from displacement of the TMJ disc. Studies in this proposal are anticipated to develop novel strategies for TMJ disc regeneration with bioactive scaffolds by endogenous stem/progenitor cells.

PI_NAMEs: LEE, CHANG HUN (contact)

PROGRAM_OFFICER_NAME: VERBRIDGE, SCOTT SPENCER

PROJECT_TERMS: 3D Print;Address;Adopted;Adverse effects;Affect;American;Anatomy;Animal Model;bioactive scaffold;Biomimetics;Cartilage;Clinical;Comparative Study;connective tissue growth factor;Cues;cytotoxicity;Dedications;Degenerative polyarthritis;delivery vehicle;Dependence;Detection;disc regeneration;Dose;Effectiveness;Encapsulated;endogenous stem cells;Engineering;Environment;Equilibrium;Excision;Fiber;Fiber Optics;Fibrocartilages;Glycolates;Goals;Growth Factor;Human;Hydrogels;image guided;imaging modality;In Situ;In Vitro;in vitro Model;in vivo;Inflammation;joint destruction;Label;Mesenchymal Stem Cells;Microspheres;Miniature Swine;minimally invasive;Modeling;National Institute of Dental and Craniofacial Research;Natural regeneration;Nature;novel;novel strategies;Operative Surgical Procedures;Oryctolagus cuniculus;Outcome;Outcome Study;Patients;Pharmacologic Substance;Physiological;polycaprolactone;Porosity;Positioning Attribute;pre-clinical;Property;Quantum Dots;recruit;reduce symptoms;Research;scaffold;self assembly;side effect;small molecule;spatiotemporal;Structure;Structure of articular disc of temporomandibular joint;Surface;System;Temporomandibular Joint;Temporomandibular Joint Disorders;Tertiary Protein Structure;tissue regeneration;Tissues;TMJ disk displacement;transforming growth factor beta3;Translations

PROJECT_TITLE: Bioactive Scaffold for TMJ Disc Regeneration by Endogenous Stem/Progenitor Cells

STUDY_SECTION: MTE

STUDY_SECTION_NAME: Musculoskeletal Tissue Engineering Study Section[MTE]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Hematology;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: Project Narrative – Overall  Defining bone marrow cell identities and states using quantitative spatial maps of RNA, protein, and N- glycans, our proposed Bone Marrow Tissue Mapping Center will dissect the cellular composition and spatial structure of bone marrow niches to understand which cells and interactions are critical to each branch of hematopoietic maturation. The multi-arm sample collection strategy, leveraging of clinically-validated pre- analytical pipelines, assay technologies (Nanostring DSP, Multiplexed Ion Beam Imaging, and MALDI-MSI), computational tools (pixel-based analyses, cell-based analyses, neighborhood analyses), and biological principles are broadly applicable to and complement other HuBMAP projects. Interrogating the interdependence between bone marrow tissue structure and hematopoiesis is informative not just in blood cell maturation, but for understanding metabolism, aging, and development of cellular therapies.

PI_NAMEs: ANGELO, ROBERT MICHAEL;BENDALL, SEAN CURTIS (contact)

PROGRAM_OFFICER_NAME: BAI, C BRIAN

PROJECT_TERMS: Affect;Age;age related changes;Aging;Anatomy;Antibodies;antimicrobial;Archives;arm;Atlases;Biological;Biological Assay;Blood Cells;Blood Group Antigens;Board Certification;bone;Bone Marrow;Bone Marrow Cells;Bone structure;Cell Maturation;Cell Therapy;Cells;cellular development;Clinical;cohort;Collection;Communities;Complement;computerized tools;Data;Data Analyses;data analysis pipeline;data pipeline;Data Set;demographics;Diagnosis;Diameter;DNA;Doctor of Philosophy;Ensure;Erythroid;ethnic diversity;femur head;Future;Gender;Genetic Transcription;glycosylation;Goals;Hematopoiesis;Hematopoietic;Hematopoietic stem cells;Hemostatic function;hip replacement arthroplasty;Histologic;Human;Human BioMolecular Atlas Program;human tissue;Image;imaging modality;Imaging technology;Length;Maps;Marrow;mass spectrometric imaging;meetings;Metabolism;Modality;Morphology;multimodality;multiplexed imaging;Multiplexed Ion Beam Imaging;multiscale data;nano-string;Neighborhoods;novel;Nutritional;Oligonucleotides;Oxygen;Pathologist;Pathology;Patients;Phenotype;Physiologic calcification;Polysaccharides;Population;preservation;Process;Production;progenitor;programs;prospective;Proteins;Protocols documentation;Quality Control;quantitative imaging;Race;Reporter;Research Personnel;rib bone structure;RNA;sample collection;Sampling;Site;Skeleton;Source;Spatial Distribution;Specimen;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;spine bone structure;Standardization;Sternum;Stromal Cells;Structure;Technology;Tissue Banks;Tissue imaging;tissue mapping;Tissues;tool;transcriptomics;Variant;Vision;Work

PROJECT_TITLE: Multimodal histologic atlas of human bone marrow


NIH_SPENDING_CATS: Aging;Clinical Research;Disability Research;Physical Rehabilitation;Rehabilitation

PI_NAMEs: FIELDING, ROGER A. (contact)

PROJECT_TERMS: Activities of Daily Living;Address;Aging;Animals;Area;Behavior;Boston;Caenorhabditis elegans;Calibration;Certification;clinical development;Clinical Research;Clinical Trials;Collaborations;COVID-19 pandemic;Development;disability;Disability status;efficacy evaluation;Elderly;Environment;Equipment;Evaluation;Exercise Physiology;experience;Face;Goals;hospital laboratories;Human;Human Resources;Impairment;Infection Control;Infrastructure;innovation;instrument;interdisciplinary collaboration;Intervention Studies;late life;Leadership;Maintenance;Measurement;Measures;Movement;Muscle;Musculoskeletal;novel;Nutritional Study;Observational Study;older adult;Older Population;Performance;Physical assessment;Physical Function;physically handicapped;preservation;procedure safety;Procedures;Protocols documentation;Quality Control;Quality of life;Research Personnel;Services;Societies;Standardization;Structure;Techniques;Technology;tool;Training;translational approach;Walking;Woman

PROJECT_TITLE: Function Assessment Core


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Breast Cancer;Cancer;Genetics;Women's Health Research

ORG_CITY: ATLANTA

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Completion of this work will provide a detailed mechanistic understanding of how SAMHD1 non-catalytically directs CtIP function in DSB repair to maintain genome integrity and govern breast cancer treatment resistance and new insights into how SAMHD1 dysregulation leads to genomic instability and development of disease, including cancer, autoimmune disease, and viral infection. In addition, this work is expected to elucidate the significance of the SIRT1 acetylome in directing SAMHD1 in DSB repair, providing new insights into the upstream signaling events governing SAMHD1 function in DSB repair and how loss of Sirt1 results in an in vivo tumor permissive phenotype. Finally, this work will establish proof of concept for the use of VLPs with Vpx in targeting SAMHD1 as a novel therapeutic approach for sensitizing resistant breast cancer to DSB-inducing agents that may significantly improve clinical outcomes.

PI_NAMEs: KIM, BAEK ;YU, DAVID SUNG-WEN (contact)

PROGRAM_OFFICER_NAME: WEINREICH, MICHAEL DALE

PROJECT_TERMS: Acetylation;Adjuvant;Autoimmune Diseases;Binding;Biochemical;Biological;Biological Models;Breast Cancer Cell;Breast Cancer Patient;Breast Cancer therapy;Breast Cancer Treatment;Cancer Control;cancer therapy;cancer type;carcinogenesis;Cells;chemotherapy;Clinical;Complex;Crystallization;cytotoxic;Data;Deacetylation;Development;Disease;DNA;DNA Damage;DNA Double Strand Break;domain mapping;Double Strand Break Repair;Event;Excision;Exhibits;Exposure to;Genetic;genome integrity;Genomic Instability;Goals;HIV-1;homologous recombination;Human;improved;In Vitro;in vivo;inhibitor therapy;innovation;insight;Ionizing radiation;Lentivirus;Lysine;Malignant Breast Neoplasm;Malignant Neoplasms;Mediating;Metabolism;Molecular Target;mouse model;Mutation;neoplastic cell;novel;novel therapeutic intervention;novel virus;nuclease;Outcome;overexpression;Pathway interactions;patient derived xenograft model;Patients;permissiveness;Phenotype;Poly(ADP-ribose) Polymerase Inhibitor;Process;Proteins;Proteomics;pseudotoxoplasmosis syndrome;radiation resistance;recombinational repair;recruit;Regulation;repaired;Resistance;response;Role;SAM Domain;Signal Transduction;Single-Stranded DNA;SIRT1 gene;Structure;targeted cancer therapy;Testing;therapy resistant;tripolyphosphate;tumor;Virus Diseases;Virus-like particle;Work

PROJECT_TITLE: Elucidating SAMHD1 in DNA Double-Strand Break Repair

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


FUNDING_MECHANISM: SBIR-STTR RPGS

ORG_CITY: LANCASTER

ORG_NAME: CERULEAN SCIENTIFIC INC.

PHR: PROJECT NARRATIVE Many patients undergoing hemodialysis require use of a catheter to secure vascular access, but complication rates are high due to infections and thrombosis; however, no available solutions successfully prevent both these complications. We developed a coating technology to reduce the complication rate with catheter use during hemodialysis by ameliorating thrombosis and infections, and our previous work optimized the coating procedure for hemodialysis catheters. In this proposal, we will complete our path to marketability with the long- term goal of improving the outcomes of patient requiring hemodialysis by reducing infection and thrombosis- related complications.

PI_NAMEs: MCFARLAND, TODD  (contact)

PROGRAM_OFFICER_NAME: GOSSETT, DANIEL ROBERT

PROJECT_TERMS: Acute;Adhesions;Adult;Animals;Back;Bacteria;Biological;biomaterial compatibility;Blood;Blood Circulation;Blood flow;Blood Vessels;Candida;canine model;Catheter-related bloodstream infection;Catheters;Cells;Certification;Clinical;commercialization;Complement Membrane Attack Complex;Complication;cost;Cyclic GMP;Cytolysis;design;Device Safety;Devices;Dialysis procedure;Domestic Sheep;Effectiveness;Engineering;Euthanasia;evaporation;FDA approved;Fibrin;Fibrinogen;Fluorocarbons;Functional disorder;fungus;genotoxicity;Goals;Good Manufacturing Process;hemocompatibility;Hemodialysis;Hemolysis Induction;Histologic;Hour;Implant;implantation;improved;improved outcome;in vivo;Incidence;Indwelling Catheter;Infection;infection rate;Liquid substance;manufacture;Manufacturer;manufacturing process;Marketing;Medical Device;Microbial Biofilms;pathogen;Pathway interactions;Patient Care;Patient-Focused Outcomes;Patients;Phase;point of care;Polyurethanes;preservation;prevent;Procedures;Process;Protocols documentation;prototype;Recommendation;Right atrial structure;Route;Secure;sheep model;Small Business Innovation Research Grant;soluble complement C5b-9;Staphylococcus aureus;Staphylococcus epidermidis;Sterilization;Structure of jugular vein;Superior vena cava structure;Surface;systemic toxicity;Technology;Testing;Thick;Thinness;Thrombosis;Tissues;Treatment Cost;United States;Veins;Work

PROJECT_TITLE: Slippery Omniphobic Coating for Hemodialysis Catheter to Resist Fibrin Sheathing and Infection and Improve Patient Outcomes


NIH_SPENDING_CATS: Aging;Bioengineering;Biomedical Imaging

PI_NAMEs: JASUJA, RAVI  (contact)

PROJECT_TERMS: Aging;Animal Model;Animals;Bioenergetics;Biopsy;Body Composition;Boston;Brain;Calibration;career;Cell model;Certification;Core Facility;Development;Disease;Dose;Equipment;Experimental Models;Fatty acid glycerol esters;Funding;Grant;Human;IACUC;imaging modality;Impairment;improved;in vivo;Infrastructure;innovation;Institution;instrument;interdisciplinary collaboration;Laboratories;Leadership;lean body mass;Longitudinal Studies;Magnetic Resonance Imaging;Magnetic Resonance Spectroscopy;Manufacturer;Measurement;Metabolic;Methodology;Methods;Microscopy;Mission;Mitochondria;Modality;model organism;Muscle;muscle form;muscle regeneration;Muscular Atrophy;NADH;Noise;non-invasive imaging;novel;Outcome;Outcome Measure;Peer Review;Performance;Physical Function;Physiological Processes;pre-clinical;Pre-Clinical Model;pre-clinical therapy;preclinical study;Procedures;Process;Protocols documentation;Publications;Quality Control;Reproducibility;Research;Research Design;Research Personnel;Resolution;Resources;response;Services;Signal Transduction;Skeletal Muscle;Standardization;Techniques;temporal measurement;Testing;Tissues;tool;Training;translational approach;Translational Research;translational study;United States National Institutes of Health;Validation;Work

PROJECT_TITLE: Pre Clinical Discovery Core


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Biomedical Imaging;Clinical Research;Digestive Diseases;Pediatric

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: PROJECT NARRATIVE  Up to 50% of children fed by gastrostomy tube suffer from feeding intolerance but, despite the high prevalence and large health impact of this issue, little is known about its pathophysiology, which hampers our ability to deliver personalized, physiology-based therapies. We hypothesize that patients with feeding intolerance have measurable impairments in gastric emptying and accommodation and that non-invasive biomarkers can be identified that are associated with symptom severity and treatment response. Through this career development award, we will use both cross-sectional and longitudinal cohort study designs to: (1) thoroughly characterize gastric mechanisms of feeding intolerance using gastric ultrasonography and nuclear medicine scintigraphy and (2) quantify the physiologic and clinical impacts of two commonly used but inadequately studied feeding intolerance treatments, erythromycin (which improves gastric emptying) and cyproheptadine (which improves gastric accommodation).

PI_NAMEs: HIRSCH, SUZANNA  (contact)

PROGRAM_OFFICER_NAME: LOH, KATRINA SHUEH WEN

PROJECT_TERMS: Address;Affect;Age;Agonist;Animals;Antral;Biological Markers;Boston;career;career development;Caring;Child;Childhood;Chronic;Clinical;clinical biomarkers;clinical decision-making;Clinical Management;Clinical Research;Clinical Trials Design;Complex;Consumption;cost;Cross-Sectional Studies;Cyproheptadine;Data;Data Analyses;design;Development;Development Plans;Diet;Discipline of Nuclear Medicine;Disease;Enrollment;Enteral Feeding;Environment;Erythromycin;evidence base;experience;feeding;Feeds;Functional disorder;Future;Gastric Emptying;gastrointestinal;gastrointestinal symptom;Gastroparesis;Gastrostomy;Goals;Growth;Health;health care service utilization;High Prevalence;Histamine Antagonists;Impairment;improved;innovation;insight;Institution;instructor;K-Series Research Career Programs;Knowledge;Literature;Longitudinal cohort study;Manometry;Measurable;Measures;Medical;medical schools;Mentors;Mentorship;Morbidity - disease rate;motilin;Motility;motility disorder;Motor;Muscarinic Antagonists;neonatal period;Nutritional;Observational Study;Oral;Outcome;Parents;patient oriented research;Patients;Pattern;Pediatric Hospitals;personalized medicine;Pharmaceutical Preparations;Physiological;Physiology;Population;preterm newborn;prospective;Prospective cohort;Prospective Studies;Public Health;Quality of life;Radiation;Radiation exposure;Radionuclide Imaging;Randomized, Controlled Trials;Research Activity;Research Design;Research Methodology;Research Personnel;Resources;Retrospective Studies;Role;Scientific Advances and Accomplishments;Serotonin Antagonists;Severities;skills;Stomach;success;Symptoms;Testing;Time;Training;treatment response;Tube;Ultrasonography;ultrasound;Vomiting

PROJECT_TITLE: Non-invasive Biomarkers of Symptom Severity and Treatment Response in Pediatric Feeding Disorders

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Neurosciences

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative This project is aimed at developing a novel approach to building generalizable models that identify the network level functional organization in the brain associated with clinical symptoms and behavior. Understanding the organizing principles of the brain as they relate to specific psychiatric symptoms and cognitive behaviors will improve diagnoses, aid in categorizing patients, identify treatment targets, allow assignment of the correct treatment to patients, and provide a quantitative means of monitoring treatment response. This work could have a major impact on the application of functional MRI in both basic neuroscience and psychiatric medicine.

PI_NAMEs: CONSTABLE, R TODD (contact);ZHAO, YIZE

PROGRAM_OFFICER_NAME: DUAN, QI

PROJECT_TERMS: Adult;Aging;Area;Atlases;Bayesian Method;Bayesian Modeling;Behavior;behavior measurement;behavior prediction;Behavioral;behavioral phenotyping;Biological;Brain;brain behavior;Brain Diseases;Categories;Clinical;Cognitive;Communities;connectome;connectome based predictive modeling;Consensus;Data;Data Set;data sharing;Development;Diagnosis;Diagnostic;Dimensions;Disease;Elasticity;Ensure;Evaluation;flexibility;Functional Magnetic Resonance Imaging;Growth;Heterogeneity;Human;human data;improved;Individual;interest;Joints;Link;Magnetic Resonance Imaging;Measures;Medicine;Mental disorders;Methodology;Methods;Mind;model generalizability;Modeling;Monitor;Neurobiology;Neurosciences;novel strategies;outcome prediction;patient subsets;Patients;Performance;Phenotype;Population;predictive modeling;psychiatric symptom;Reproducibility;Research;Research Domain Criteria;Resources;Running;Sampling;Site;Subgroup;support network;Symptoms;System;Tissues;treatment group;treatment response;United States National Institutes of Health;unsupervised clustering;Validation;Variant;Work

PROJECT_TITLE: An integrative Bayesian approach for linking brain to behavioral phenotype

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Organ Transplantation;Pulmonary Fibrosis;Rare Diseases;Social Determinants of Health;Transplantation

PI_NAMEs: KIEL, DOUGLAS P. (contact)

PROJECT_TERMS: accelerated epigenetic aging;Adult;Affect;Age;age acceleration;Aging;Animal Model;Applications Grants;Behavior Therapy;Biological Markers;Boston;Capsicum;career;Cell Aging;Data;Development;DNA Methylation;Doctor of Philosophy;dosage;early life stress;Epigenetic Process;exercise capacity;exercise intervention;Exposure to;Fibroblasts;follow-up;Fostering;functional decline;Funding;Gender;Generations;human study;idiopathic pulmonary fibrosis;improved;Inflammaging;Inflammation;Inflammatory;Infrastructure;innovation;Intellectual Property;Interdisciplinary Study;Interleukin-6;interstitial;Interstitial Lung Diseases;Intervention;Investigation;Legal patent;Life Cycle Stages;Link;Lung;Lung Diseases;lung imaging;medical schools;Mentorship;Mission;model organism;Muscle function;older adult;Organ;Organ Transplantation;Outcome;Outcome Study;Participant;patient stratification;Patients;Peer Review;peripheral blood;Persons;Physical Function;physical impairment;pilot test;pre-clinical;Productivity;programs;Proteomics;Protocols documentation;Psychosocial Stress;psychosocial stressors;Publications;Pulmonary Fibrosis;randomized trial;Request for Applications;Research;Research Personnel;Research Project Grants;Resources;response;Role;Safety;Science;Scientific Advances and Accomplishments;Scientist;senescence;senescence associated secretory phenotype;senescent cell;senolytics;Skeletal Muscle;Stress;Testing;Time;transgender;translational approach;translational pipeline;Translational Research;Transplantation

PROJECT_TITLE: Pilot and Exploratory Core


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Genetics;Human Genome;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: KANSAS CITY

ORG_NAME: CHILDREN'S MERCY HOSP (KANSAS CITY, MO)

ORG_STATE: MO

PHR: PROJECT NARRATIVE Genome sequencing has enabled great advances in the diagnosis of pediatric rare diseases, but the majority of cases still go unsolved. One issue is that many cases cannot be explained by a single mutation, but instead are caused by an accumulation of mutations across many genes. We will provide computational and statistical methods integrating diverse functional and genomic resources across 1,900 rare disease individuals to accurately identify these complex, non-Mendelian causal mechanisms of pediatric rare disease phenotypes, increasing the potential to diagnose unsolved patient cases.

PI_NAMEs: SMAIL, CRAIG  (contact)

PROGRAM_OFFICER_NAME: MASKERI, BAISHALI

PROJECT_TERMS: biobank;Biological Assay;Cell Line;Child;Childhood;Clinical;Code;Collaborations;Complex;computerized tools;Computing Methodologies;Developmental Gene;Diagnosis;Diagnostic;Disease;disease phenotype;disorder risk;Enrollment;exome;exome sequencing;functional genomics;Gene Expression Regulation;Genes;Genetic Diseases;Genetic Processes;genome resource;genome sequencing;genome-wide;Genomics;Genotype-Tissue Expression Project;Hospitals;improved;Individual;induced pluripotent stem cell;Maps;Methods;Midwestern United States;Modeling;Molecular;molecular phenotype;Mutation;novel;novel diagnostics;patient derived induced pluripotent stem cells;Patients;pediatric patients;Population;Process;programs;Protein Isoforms;Rare Diseases;rare mendelian disorder;rare variant;Research;Resources;RNA Splicing;single cell ATAC-seq;single-cell RNA sequencing;Statistical Methods;System;Tissues;United States National Institutes of Health;Untranslated RNA;Variant

PROJECT_TITLE: Mapping causal genetic processes in non-Mendelian pediatric rare disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-GGG-S(55)]


PI_NAMEs: TRAVISON, THOMAS GLENN (contact)

PROJECT_TERMS: academic standard;Address;Aging;Ally;American;Architecture;bioinformatics tool;Biometry;Biostatistics Core;Boston;Capsicum;Clinical;Cognition;Collaborations;Communities;Computer software;Consultations;cost;Data;Data Analyses;data management;Data Science;Data Science Core;Dedications;design;Development;education research;Educational Curriculum;Experimental Designs;Faculty;Funding;Genetic;Goals;implantable device;improved;Industry Standard;informatics tool;innovation;instrument;International;Longevity;Measurement;Measures;Medical History;meetings;Mentorship;Methodology;Methods;Mission;Monitor;Names;novel;older adult;Population;Pragmatic clinical trial;prevent;Productivity;programs;Publications;Publishing;Reporting;Reproducibility;Research;Research Design;Research Personnel;Resources;Science;science education;Scientist;software development;software repository;Software Tools;Statistical Methods;statistics;success;Survival Analysis;System;Time;tool;Training;Training Activity;Training and Education;Training Programs;translational approach;wearable device;web based software;Work

PROJECT_TITLE: Biostatistics and Data Science Core


NIH_SPENDING_CATS: Aging;Clinical Research

PI_NAMEs: LIPSITZ, LEWIS  (contact)

PROJECT_TERMS: Age;Aging;Animals;Area;Award;Basic Science;Boston;career;career development;Clinical Sciences;Data;Development;disability;Discipline;Disease;Education;education research;Educational Activities;experience;Funding;Future;Future Generations;Goals;Health;Human;human old age (65+);improved;Individual;Intervention;K-Series Research Career Programs;Knowledge;lectures;Mentors;Mentorship;novel;Nursery Schools;Personal Satisfaction;Persons;Physical Function;Research;Research Personnel;Science;Scientist;skills;Talents;Testing;Training;Translating;translational approach;Translational Research;Vocational Guidance;Work

PROJECT_TITLE: Research Education


ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: The proposal represents a longer-term plan that will develop a new and re-imagined generation of medical imaging instrumentation. It is founded on a partnership of unparalleled instrumentation development capability, coupled with cutting-edge capability in implementing advanced algorithms for multi-dimensional image generation. This will accelerate development, growth and clinical translation of new promising emerging cancer therapy methods. It will also lead to technology advancement that will enable research community and industry in developing next generation clinical imaging instrumentations.

PI_NAMEs: DU, YONG ;FREY, ERIC C.;MENG, LING-JIAN ;SGOUROS, GEORGE  (contact)

PROGRAM_OFFICER_NAME: TORNAI, MARTIN PAUL

PROJECT_TERMS: 3-Dimensional;Acceleration;Algorithms;Alpha Particle Emitter;Animals;Area;Automobile Driving;bone;Canada;cancer cell;Cancer Patient;cancer therapy;Cardiology;Characteristics;Clinical;clinical imaging;Clinical Research;clinical translation;Communicable Diseases;Communities;Complex;compound eye;Consent;Coupled;Daughter;DCNU;design;detection platform;detector;Development;Devices;Diagnosis;Diameter;Dimensions;Discipline of Nuclear Medicine;Distributional Activity;Dose;dosimetry;Ensure;Evaluation;experience;Fostering;Gamma Cameras;Gamma Rays;Generations;Grant;Growth;Half-Life;Image;image reconstruction;imaging modality;Imaging technology;improved;Industry;Institutional Review Boards;instrumentation;Interdisciplinary Study;Investigation;Isotopes;kidney cortex;Knowledge;Lesion;Manufacturer;Medical Imaging;Medicine;Metastatic Prostate Cancer;Methods;Modality;Neurology;next generation;Normal tissue morphology;Oncology;Organ;Parents;Patients;Performance;Photons;Physics;precision medicine;preclinical study;Property;Protocols documentation;quantitative imaging;Radiation;Radiation exposure;Radioisotopes;Radiopharmaceuticals;Radium;reconstruction;Research;Research Personnel;Resolution;Rheumatology;Roentgen Rays;Role;routine imaging;Scheme;single photon emission computed tomography;Specific qualifier value;standard of care;success;System;targeted imaging;Techniques;Technology;technology development;theranostics;Thick;Toxic effect;treatment planning;tumor;ultra high resolution;Universities;uptake

PROJECT_TITLE: High Energy and Spatial Resolution Multi-Isotope SPECT Imaging of Targeted Alpha-Emitters and their Daughters


NIH_SPENDING_CATS: Cancer;Genetics;Orphan Drug;Ovarian Cancer;Rare Diseases;Women's Health Research

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE Limited therapeutic options and drug resistance are major clinical problems in ovarian cancer treatment. We will conduct mechanistic and preclinical studies on CDK7-targeted therapy for treatment of high-grade serous ovarian carcinoma. Our proposed studies may provide strong rationale for clinical development of CDK7 inhibitors in oncology.

PI_NAMEs: ZHANG, LIN  (contact)

PROGRAM_OFFICER_NAME: O'HAYRE, MORGAN

PROJECT_TERMS: addiction;Affect;analog;C-terminal;cancer cell;Cancer Etiology;cancer genome;cancer therapy;cancer type;Cell Cycle;Cell Death;Cell Physiology;Cells;Cessation of life;chemotherapy;chromosome 5q loss;Clinic;Clinical;clinical development;Combined Modality Therapy;Communication;Cyclin-Dependent Kinase Inhibitor;Cyclin-Dependent Kinases;Cyclins;Dependence;Diagnosis;DNA Damage;DNA Repair;DNA Sequence Alteration;Dose;Drug resistance;Dysmyelopoietic Syndromes;early phase clinical trial;Enhancers;Essential Genes;FDA approved;fusion gene;Gene Expression;gene repression;Genes;Genetic Transcription;Goals;homologous recombination;homologous recombination deficiency;Impairment;in vivo Model;inhibitor;lenalidomide;Malignant Epithelial Cell;Malignant Female Reproductive System Neoplasm;Malignant neoplasm of ovary;Malignant Neoplasms;Medical;Molecular;Molecular Biology;mutant;Mutation;Nature;new therapeutic target;novel strategies;Oncology;Ovarian Serous Adenocarcinoma;Pathway interactions;patient population;Patients;Pharmaceutical Preparations;Phosphorylation;Platinum;Poly(ADP-ribose) Polymerase Inhibitor;Pre-Clinical Model;preclinical study;programs;Recurrence;Relapse;Reporting;Repression;Resistance;Resources;response;Revlimid;RNA Polymerase II;RNA Processing;Solid Neoplasm;structural biology;targeted treatment;taxane;Testing;Therapeutic;Transcript;translational medicine;translational potential;Translational Research;treatment response;treatment strategy;tumor;United States;Women's mortality

PROJECT_TITLE: Targeting CDK7 in high-grade serous ovarian carcinoma

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 1 Study Section[MCT1]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Brain Disorders;Depression;Drug Abuse (NIDA only);Mental Health;Mental Illness;Neurosciences;Serious Mental Illness;Substance Misuse

ORG_CITY: DAVIS

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Project Narrative Serotonin (5HT) activates more than 20 different GPCRs that couple to every class of G protein. Many drugs use in clinical medicine target 5HTRs and much is known about how these drugs influence G protein signaling from the receptor. However, almost nothing in known about the endocytic and post-endocytic trafficking properties of the 5HTRs either in response to 5HT itself or drugs that target the 5HTRs, despite that fact that receptor recycling and degradation have dramatic and opposing effects on signal transduction. This proposal will address this gap in knowledge.

PI_NAMEs: WHISTLER, JENNIFER L (contact)

PROGRAM_OFFICER_NAME: ANANTHAN, SUBRAMANIAM

PROJECT_TERMS: Acute;Adult;Affinity;Agonist;anti-depressive agents;Attention;Attention deficit hyperactivity disorder;autism spectrum disorder;Behavior;Binding;Bipolar Depression;Bipolar Disorder;Bone Density;Brain;Calcium;Cell membrane;Cells;Central Nervous System Diseases;Clinical Medicine;Coupled;Cytoplasmic Tail;Data;Degradation Pathway;desensitization;design;Desire for food;Disease;drug efficacy;Drug Targeting;Drug usage;Early Endosome;Endocytosis;Equilibrium;Event;experimental study;Family;G-Protein-Coupled Receptors;Genes;genetic variant;Genetic Variation;Goals;GTP-Binding Proteins;Hallucinogens;Hour;Human;Immune response;Intervention;Ion Channel Gating;Knock-out;Knowledge;Libido;Ligands;Link;Lysosomes;Major Depressive Disorder;Mediating;member;Mental Depression;Modality;Moods;Neurons;novel strategies;Obsessive-Compulsive Disorder;Outcome;Pathway interactions;Patients;Peripheral;Pharmaceutical Preparations;pharmacologic;Pharmacologic Substance;Platelet aggregation;Property;Protein Sortings;receptor;receptor expression;receptor recycling;Receptor Signaling;Recycling;reduce symptoms;response;reuptake;RNA Splicing;Schizophrenia;segregation;Selective Serotonin Reuptake Inhibitor;Serotonergic System;Serotonin;serotonin receptor;Signal Pathway;Signal Transduction;Signaling Protein;Sleep;Sorting;Syndrome;Testing;theories;Therapeutic;Time;trafficking;Treatment Efficacy;triptans;Variant

PROJECT_TITLE: Trafficking properties of the serotonin receptor variants

STUDY_SECTION: MCNP

STUDY_SECTION_NAME:
Molecular and Cellular Neuropharmacology Study Section
[MCNP]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;Genetics;Infectious Diseases;Lung;Orphan Drug;Rare Diseases

ORG_CITY: TORRANCE

ORG_NAME: LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER

PHR: Narrative Aspergillus fumigatus is the principal cause of invasive aspergillosis, which is a frequently deadly and increasingly common disease in immunocompromised patients. The goal of this project is to characterize a novel transcriptional regulator in A. fumigatus that governs host cell interactions and virulence and to discover the downstream effector genes that are controlled by this regulon.

PI_NAMEs: FILLER, SCOTT G (contact);MOYE-ROWLEY, W SCOTT

PROGRAM_OFFICER_NAME: LOVE, DONA

PROJECT_TERMS: Abbreviations;Antifungal Therapy;Aspergillosis;Aspergillus;Aspergillus fumigatus;Attenuated;Azole resistance;Binding;Biology;Bone Marrow;Candida albicans;Cell Communication;Cells;ChIP-seq;chromatin immunoprecipitation;Data;Defect;Diagnosis;diagnostic development;Disease;Electrophoretic Mobility Shift Assay;EMSA;Epidermal Growth Factor;Epidermal Growth Factor Receptor;Epithelial Cells;experimental study;Family;Fright;fungus;Gene Targeting;Genes;Genetic Transcription;Genome;genome-wide;Goals;Growth;Hemagglutinin;high risk;Histoplasma capsulatum;Hypoxia;Immunocompromised Host;improved;In Vitro;Incidence;Infection;innovation;interest;Invaded;Investigation;Life;Lung;lung injury;Macrophage;Mediating;member;mortality;mouse model;mutant;novel;novel diagnostics;novel therapeutics;Organism;overexpression;Pathogenesis;Pathogenicity;Pathway interactions;Population;Predisposition;Prevention;promoter;Proteins;Reactive Oxygen Species;Regulon;Response Elements;Role;targeted treatment;Testing;Therapeutic;therapeutic development;trait;transcription factor;transcriptome sequencing;Vaccines;Virulence;Work

PROJECT_TITLE: Transcriptional networks governing A. fumigatus virulence

STUDY_SECTION: PTHE

STUDY_SECTION_NAME: Pathogenic Eukaryotes Study Section[PTHE]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: AMES

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: IOWA STATE UNIVERSITY

ORG_STATE: IA

PHR: Project Narrative This project seeks to develop advanced tools to enable faster discovery and design of protein-based drugs for new disease targets. These tools would enable optimization of multiple parameters simultaneously, creating more potent therapies with less side effects. Thanks to speeding up the development cycle and reducing the time to market, these tools also have the potential to reduce end cost to patients.

PI_NAMEs: REUEL, NIGEL F (contact)

PROGRAM_OFFICER_NAME: SALVADOR MORALES, CAROLINA

PROJECT_TERMS: Affinity;Algorithms;Big Data;Binding;Binding Proteins;bioelectronics;Biological Products;Biological Response Modifier Therapy;Biomanufacturing;Biosensor;Black Box;Cell membrane;Cells;Clinic;cost;Coupled;Custom;Data Set;deep learning;deep neural network;design;design,build,test;Development;Devices;Disease;DNA biosynthesis;efficacious treatment;Engineering;falls;Funding;Future;Generations;Genetic Template;improved;in silico;In Vitro;Iowa;Label;Libraries;Machine Learning;manufacture;Marketing;Measurement;Membrane;Methods;Microfluidics;nanosensors;new technology;novel strategies;Optics;Patients;Pattern;Penetration;Phenotype;programs;Property;Protein Biosynthesis;Protein Engineering;Proteins;prototype;radio frequency;Research;sensor;side effect;Small Business Innovation Research Grant;Speed;Stream;Surface;synthetic biology;System;Techniques;Technology;Testing;therapeutic protein;Therapeutic Uses;Time;timeline;tool;Training;Translating;treatment optimization;United States National Institutes of Health;Universities;Vision;water quality;Work;wound healing

PROJECT_TITLE: Unsupervised optimization of protein therapeutics using closed-loop in vitro synthesis, nanosensing, and deep-learning

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-N(55)R]


ED_INST_TYPE: OTHER SPECIALIZED SCHOOLS

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: SYRACUSE

ORG_DEPT: MISCELLANEOUS

ORG_NAME: SYRACUSE UNIVERSITY

PHR: The overarching objective of this project is to understand how U.S. state policies and county economic conditions have jointly contributed to the large and growing geographic disparities in midlife mortality, psychosocial wellbeing, and health behaviors. It develops innovative measures of state policy contexts and county economic conditions over 40 years to predict 1) deaths from all causes, 2) deaths from specific causes driving the rise in midlife mortality (drug overdose, alcohol poisoning, suicide, and cardiometabolic diseases), and 3) the psychosocial and behavioral risk factors for those causes of death. The findings can inform broad policy responses and targeted interventions to reduce the geographic disparities in midlife mortality in the U.S.

PI_NAMEs: MONNAT, SHANNON M;MONTEZ, JENNIFER KARAS (contact)

PROGRAM_OFFICER_NAME: JAIN, KRITI MUNJAL

PROJECT_TERMS: Academy;Address;Adult;Affect;Age;age group;alcohol poisoning;Alcohols;Appalachian Region;Area;Automobile Driving;Bachelor's Degree;Behavioral;Black race;Bundling;Cardiometabolic Disease;Cardiovascular Diseases;Cause of Death;Cessation of life;Cities;Code;college;Communities;Consumption;County;COVID-19 pandemic;Data;data enclave;data resource;Data Set;Death Rate;demographics;Diabetes Mellitus;Dimensions;Disparity;Documentation;Drug usage;Economic Conditions;Economics;Education;Educational workshop;Employment;Ethnic Origin;Ethnic Population;Etiology;experience;Family;fast food;Female;Food;food consumption;Funding;geographic disparity;Geographic Locations;Geography;Health behavior;health disparity;Hispanic;Hypertension;Income;Individual;innovation;Instruction;Intervention;Knowledge;large datasets;Life;Life Expectancy;Link;local economy;male;Measures;Mental Health;Methods;metropolitan;Michigan;middle age;Midwestern United States;mortality;mortality disparity;National Institute of Drug Abuse;Not Hispanic or Latino;novel strategies;Occupations;Overdose;Pathway interactions;Pattern;Personal Satisfaction;Pharmaceutical Preparations;Policies;Population;Predictive Factor;Process;psychosocial;psychosocial wellbeing;Race;racial population;Reporting;Research;Resources;response;Risk;Risk Factors;rural area;satisfaction;sex;Shapes;social;social determinants;Suicide;Surveys;System;trend;Universities;virtual;Vital Statistics;web page;White Women;Work

PROJECT_TITLE: Geographic Trends And Disparities In Psychosocial Wellbeing, Health Behaviors, And Mortality In Midlife

STUDY_SECTION: SSPB

STUDY_SECTION_NAME: Social Sciences and Population Studies B Study Section[SSPB]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Hematology;Immunotherapy;Infectious Diseases;Influenza;Lung;Pneumonia;Pneumonia and Influenza;Sepsis

ORG_CITY: SAN ANTONIO

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

ORG_STATE: TX

PHR: Project Narrative Increased susceptibility to secondary bacterial pneumonia after recovery from primary influenza infection is an important clinical complication. Host immune factors, rather than pathogen associated molecules, are now well recognized as central players in determining susceptibility to secondary infection. However, the underlying mechanisms are poorly understood. Our proposed studies elucidate a novel transcriptional gatekeeping mechanism involved in dysregulated immune response of alveolar macrophages to secondary bacterial infection. We identify immune and epigenetic factors that imprint an immunological memory in alveolar macrophages during prior influenza infection, that causes these cells to mount an early and exaggerated inflammatory response upon subsequent secondary bacterial infection, resulting in sepsis and severe disease. Our proposal identifies novel therapeutic targets that will have significant impact on designing measures to correct the innate immune cell dysfunction, not only in secondary infections but also in other airway diseases.

PI_NAMEs: MISHRA, BIBHUTI BHUSAN (contact);SHARMA, JYOTIKA

PROGRAM_OFFICER_NAME: ARNOLD, MICHELLE MARIE

PROJECT_TERMS: Acceleration;Airway Disease;Alveolar Macrophages;Atherosclerosis;Bacteria;Bacterial Infections;Bacterial Pneumonia;Cells;Characteristics;Chromatin Remodeling Factor;Cicatrix;Clinical;clinically relevant;combat;Communication;Complication;cytokine;cytokine release syndrome;Data;Defect;Dendritic Cells;design;Development;Disease;Environment;Epigenetic Process;Exhibits;Experimental Models;Fostering;Functional disorder;Future;Gatekeeping;Gene Expression;Genes;Genetic Transcription;genome-wide;Goals;Gram-Positive Bacteria;Immune;Immune response;Immune Tolerance;Immunity;Immunologic Factors;Immunologic Memory;Immunologics;Immunology;Immunosuppression;imprint;Individual;Infection;Inflammatory;Inflammatory Response;Influenza;influenza infection;insight;Interferon Type II;Interferons;Invaded;Klebsiella pneumoniae;Knowledge;Limes;Lung;Macrophage;Malignant Neoplasms;Measures;Mediating;Memory;Molecular;Mus;Nature;new therapeutic target;novel;Outcome;pathogen;pathogenic bacteria;Pathologic;Pathology;Patients;Phagocytes;Phase;Phenotype;Play;Pneumonia;Polymerase;Predisposition;prevent;Primary Infection;Process;Productivity;promoter;Protein Inhibition;Protein-Arginine N-Methyltransferase;Proteins;Pulmonary Inflammation;Recovery;recruit;Reporting;Resolution;response;RNA Polymerase II;Role;secondary infection;Secondary to;Sepsis;Severity of illness;Staphylococcus aureus;Stimulus;Streptococcus pneumoniae;T-Lymphocyte;Techniques;Therapeutic;Time;Training;Transcription Initiation Site;Transcriptional Activation;transcriptional reprogramming;Transforming Growth Factor beta;tumor-immune system interactions;Vaccination;Virus Diseases;Work

PROJECT_TITLE: Lung Macrophage Memory Development and Responses in Secondary Pneumonia and Sepsis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIB-S(02)]


NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Clinical Research;Dental, Oral, and Craniofacial Disease;Orphan Drug;Precision Medicine;Radiation Oncology;Rare Diseases

ORG_CITY: FAYETTEVILLE

ORG_NAME: UNIVERSITY OF ARKANSAS AT FAYETTEVILLE

ORG_STATE: AR

PHR: PROJECT NARRATIVE Improving outcomes associated with treatment of head and neck cancers demands early determination of metabolic, functional and molecular changes that unfold in the tumor microenvironment. The current proposal leverages non-invasive, quantitative, and frequent measurements to reveal the poorly understood time-course of biological responses to clinically relevant doses of radiation and chemotherapy using diffuse reflectance and Raman spectroscopy. Furthermore, we will develop an endoscope-compatible multimodal optical probe for in vivo monitoring of treatment resistance that will enable real-time determination of spectral markers, and therefore, provide the rationale for personalizing treatment for patients with head and neck squamous cell carcinoma.

PI_NAMEs: RAJARAM, NARASIMHAN  (contact)

PROGRAM_OFFICER_NAME: WU, YICONG

PROJECT_TERMS: Anatomy;Bioenergetics;Biological;Biological Process;Catabolism;Cell Line;chemoradiation;Chemoresistance;chemotherapy;Chemotherapy and/or radiation;Clinic;Clinical;clinical imaging;clinical practice;Clinical Research;Clinical Treatment;clinically relevant;Data;Databases;design;Development;Diffuse;diffuse reflectance spectroscopy;Early identification;Endoscopes;Evaluation;Failure;Fatty Acids;fractionated radiation;Glucose;Glycogen;Glycolysis;Goals;Head and Neck Cancer;head and neck cancer patient;Head and Neck Squamous Cell Carcinoma;Hemoglobin;histological studies;Human;Human Papillomavirus;Image;improved;improved outcome;In complete remission;in vivo;in vivo monitoring;individual response;ineffective therapies;Kinetics;Knowledge;Laryngoscopes;Lipids;Malignant Neoplasms;Maps;Measurement;Metabolic;Metabolism;metabolome;metabolomics;Methods;Microscopy;Modality;Modeling;Molecular;molecular marker;Monitor;multimodality;Mus;Operative Surgical Procedures;Optics;optimal treatments;Oxygen Consumption;Pain;Pathway interactions;Patients;Pentosephosphate Pathway;personalized medicine;Play;preclinical study;predictive marker;primary outcome;Process;programs;Publishing;Quality of life;Radiation;Radiation Dose Unit;Radiation Monitoring;radiation resistance;radiation response;Radiation therapy;Radiobiology;radioresistant;Raman Spectrum Analysis;Regimen;Research;Resistance;responders and non-responders;response;Role;Schedule;Shapes;side effect;Spectrum Analysis;Survival Rate;Testing;Therapeutic;therapy resistant;Time;tool;Translating;Translations;Treatment Failure;Treatment Protocols;treatment responders;treatment response;tumor;tumor metabolism;tumor microenvironment;Tumor Oxygenation;tumor progression;Tumor stage;tumor xenograft;Work;X-Ray Computed Tomography

PROJECT_TITLE: Determination of functional and molecular biomarkers of treatment resistance with multimodal optical spectroscopy

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]


ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Morphogenesis, the biological process that causes cells or tissues to attain their characteristic shape, is highly conserved throughout phylogeny and is fundamental to development and wound healing. We use powerful imaging, genetic, biochemical and biophysical approaches to investigate cell sheet morphogenesis in a model system, Drosophila melanogaster. Our studies are designed to probe the molecular function of key players in contractility (the motor proteins, myosins) and to identify new genes that regulate and drive cell sheet movements, then investigate the molecular basis for how the genes c0ntribute to such morphogenesis – our work continues to provide important insights into the basic biological mechanisms that go awry in human pathologies such as cardia bifida, spina bifida, cleft palate and wound-induced, epithelial lesions.

PI_NAMEs: KIEHART, DANIEL PETER (contact)

PROGRAM_OFFICER_NAME: WELLS, MELISSA LYNN

PROJECT_TERMS: Actomyosin;Address;Adhesions;Animals;Biochemical;Biological;Biological Models;Biological Process;Biophysical Process;biophysical techniques;Biophysics;Cell Communication;Cell Shape;Cells;Cellular biology;Characteristics;Chromosomes;Cleft Palate;Complex;Cytoskeleton;Defect;design;Development;Developmental Process;Dorsal;Drosophila genus;Drosophila melanogaster;Embryo;Epithelium;fly;forward genetics;Functional disorder;gastrulation;Gene Expression;gene product;Genes;Genetic;Genome;Goals;Heart;Homeostasis;Human Pathology;Image;imaging genetics;insight;Instruction;interdisciplinary approach;interest;Kinetics;Lateral;Lesion;Mechanics;Molecular;Molecular Probes;Morphogenesis;Motor;Movement;mutant;Mutation;Myosin ATPase;Myosin S-2;Neural tube;Palate;Phenotype;Phylogeny;Positioning Attribute;Predisposition;Process;Proteins;Regulation;Research;resilience;reverse genetics;RNA Splicing;Shapes;Signal Transduction;Spinal Dysraphism;stomach cardia;Sum;Thermodynamics;Tissues;transmission process;Work;wound;wound healing

PROJECT_TITLE: Morphogenesis: Biophysics and Genetics of Dorsal Closure

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Heart Disease;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: PROJECT NARRATIVE Sinoatrial node dysfunction that affects one in 600 people over 65 years of age is mainly treated by an implantable pacemaker to restore the sinus rhythm; however, electronic devices have inherently insurmountable design limitations. The goal of this proposal is to understand how the microenvironment and imposed forces affect the pacemaking function in pacemaking cells differentiated from human induced pluripotent stem cells (hiPSCs). Findings form this study can generate a sustainable source of pacemaking cells for engineering biopacemakers that circumvent limitations associated with electronics and inspire new therapeutic strategies or preventive measures for sinoatrial node dysfunction.

PI_NAMEs: LIEU, DEBORAH K (contact)

PROGRAM_OFFICER_NAME: LUNDBERG, MARTHA

PROJECT_TERMS: Adherens Junction;Affect;Age Years;Aging;Binding;Biochemical;Biomechanics;Biosensor;Cardiac;Cardiac Myocytes;Cell Differentiation process;Cell membrane;Cells;cellular engineering;Clinical;Collagen;Complex;Data;density;design;Development;Electronics;Engineering;Environment;Exposure to;Extracellular Matrix;Fascia adherens;Felis catus;fetal;Focal Adhesion Kinase 1;Future;gain of function;Gap Junctions;Gene Expression;Goals;HCN4 gene;heart rhythm;Human;human induced pluripotent stem cells;human old age (65+);Implant;In Vitro;in vivo;induced pluripotent stem cell derived cardiomyocytes;insight;Integrins;Intercellular Junctions;Left;Left ventricular structure;Ligands;loss of function;Maintenance;Mass Spectrum Analysis;mechanical force;mechanical properties;mechanotransduction;Mediating;member;Microscopy;N-Cadherin;novel;novel therapeutic intervention;novel therapeutics;Pacemakers;Patients;Periodicity;Persons;Phenotype;Prevention strategy;Preventive measure;Property;protein degradation;Protein Isoforms;Proteins;Reporting;Role;Shapes;Sick Sinus Syndrome;Signal Transduction;Signaling Protein;Sinoatrial Node;Sinus;Source;Testing;Therapeutic;Tissues;transmission process;Ventricular

PROJECT_TITLE: Forcing the sinoatrial node pacemaker function

STUDY_SECTION: CDD

STUDY_SECTION_NAME: Cardiovascular Differentiation and Development Study Section[CDD]


ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: Project Narrative The ability of cells to regulate proteostasis in response to protein unfolding and aggregation is essential for their survival and health. In this project, we propose a multi-model approach to determine how protein AMPylation regulates the proteostasis network in health and disease. The results of our studies will expand our understanding of the processes that control proteostasis and protein aggregation, which will immediately benefit our efforts to develop novel therapies for aging- and protein aggregation-associated diseases.

PI_NAMEs: TRUTTMANN, MATTHIAS CHRISTOF (contact)

PROGRAM_OFFICER_NAME: PHILLIPS, ANDRE W

PROJECT_TERMS: Address;Aging;alpha synuclein;Amyloid beta-Protein;Biochemistry;Biological Models;Biological Process;Caenorhabditis elegans;Cell Nucleus;Cells;Cytoplasm;Data;Dedications;design;Disease;Enzymes;Genetic;Goals;Health;Human Cell Line;In Vitro;in vitro Assay;in vivo;insight;Intervention;Knowledge;Mediating;Modeling;Molecular;mouse model;Nematoda;novel;novel strategies;novel therapeutics;Organism;Pathway interactions;Physiological;Physiology;polyglutamine;preference;prevent;Process;programs;protein aggregation;protein folding;protein purification;Proteins;proteostasis;Regulation;Research;response;Role;Signal Transduction;Techniques;therapeutic development;Therapeutic Intervention;tool;translational potential

PROJECT_TITLE: Conserved regulation of proteostasis by post-translational protein AMPylation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-Q(55)R]


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Clinical Research;Congenital Structural Anomalies;Genetics;Kidney Disease;Orphan Drug;Pediatric;Polycystic Kidney Disease;Precision Medicine;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE Using inducible pluripotent stem cells from patients with two severe forms of kidney diseases that have a large genetic component (Focal Segmental Glomerulosclerosis or FSGS, and Polycystic Kidney Disease or PKD) we will make patient specific human kidney on a chip devices. These devices will then be used to help guide our efforts for successful clinical trials of novel treatments for FSGS and PKD.

PI_NAMEs: FREEDMAN, BENJAMIN SOLOMON (contact);HIMMELFARB, JONATHAN ;KRETZLER, MATTHIAS

PROGRAM_OFFICER_NAME: HARGROVE, PASSLEY R

PROJECT_TERMS: absorption;Accounting;Address;Affect;Animal Model;Architecture;Autosomal Dominant Polycystic Kidney;Bioinformatics;Biological Models;Biology;biomarker discovery;biomarker evaluation;Biomedical Engineering;Biomedical Research;Biometry;Blood Vessels;Cause of Death;Cells;Cellular biology;Centers for Disease Control and Prevention (U.S.);Cessation of life;Clinical;clinical phenotype;clinical trial on a chip;Clinical Trials;Clinical Trials Design;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;Complex;Computational Biology;Data;design;Development;Devices;differentiation protocol;Disease;disease model;drug development;effective therapy;Engineering;Etiology;Expenditure;Failure;Focal and Segmental Glomerulosclerosis;Funding;gene editing technology;Gene Expression Profiling;Genes;Genetic;Genomics;glomerular filtration;Goals;Heterogeneity;Histologic;Histopathology;Human;Human Genetics;Image;In Vitro;in vitro Model;in vivo;Individual;induced pluripotent stem cell;insight;Internal Medicine;Kidney;kidney cell;Kidney Diseases;Kidney Failure;kidney vascular structure;materials science;medical specialties;Medicare;Microfluidics;microphysiology system;Modeling;Modernization;Molecular;Molecular Biology;Molecular Profiling;multidisciplinary;National Center for Advancing Translational Sciences;Natural History;Nephrology;Nephrons;Nephrotic Syndrome;novel;novel therapeutics;organ on a chip;Organoids;Outcome;outcome prediction;Pathogenesis;Pathology;Pathway interactions;patient response;patient stratification;Patients;Persons;Pharmacology and Toxicology;Phenotype;phenotypic data;Physiological;Physiological Processes;Physiology;Polycystic Kidney Diseases;precision medicine;profiles in patients;protocol development;Public Health;Publishing;randomized, clinical trials;Rare Diseases;Reporting;Resources;response;response to injury;Safety;stem cell biology;success;System;targeted therapy trials;Taxonomy;Testing;Therapeutic;therapeutic evaluation;Tissue Microarray;tool;Translating;treatment response;trial planning;Tubular formation;United States National Institutes of Health

PROJECT_TITLE: Safety and Efficacy of Human Clinical Trials Using Kidney-on-a-Chip Microphysiological Systems


ED_INST_TYPE: GRADUATE SCHOOLS

ORG_DEPT: BIOLOGY

ORG_NAME: ROCKEFELLER UNIVERSITY

PHR: Project Narrative Novel mechanisms for post-transcriptional gene expression regulation continue to emerge. I recently identified the role of ribosome to enhance translation of canonical open reading frames by translating small ORFs (downstream ORFs or dORFs) in the 3’UTR. Since dORF is a novel, widespread and strong regulatory element among vertebrates, this proposal aims to study the mechanism of dORF regulation and the biological impact of dORF dysregulation in cancer. This will help us better understand post-transcriptional regulation in cancer and further, may provide dORF as new diagnostic regions of the mRNA and potential targets for drug design.

PI_NAMEs: WU, QIUSHUANG  (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: 3' Untranslated Regions;5' Untranslated Regions;Affect;Award;Bioinformatics;Biological;Biological Assay;Cancer Biology;cancer cell;Cancer Etiology;Candidate Disease Gene;career;Cells;Cellular biology;Clinical;Conserved Sequence;Data;Databases;Development;Disease;DNA;Drug Design;Drug Targeting;Embryo;Eukaryotic Cell;Future;Gene Expression;Gene Expression Regulation;gene repression;Genes;Genetic Transcription;genome-wide;genomic profiles;Genomics;Health;Human;Human Cell Line;human disease;innovation;insight;interest;Kidney Neoplasms;Kinetics;Knowledge;Light;machine translation;Malignant Neoplasms;Measures;Mediating;Messenger RNA;Methodology;MicroRNAs;Molecular;Molecular Biology;molecular imaging;mRNA Stability;Mutation;novel;novel diagnostics;Open Reading Frames;Orthologous Gene;Outcome;Pathogenesis;Pathologic;Patients;Pattern;Peptide Initiation Factors;Peptides;Polyadenylation;Population;Post-Transcriptional Regulation;Postdoctoral Fellow;posttranscriptional;Process;Proteins;Proteomics;Publishing;Regulation;Regulatory Element;Regulatory Pathway;Reporter;Reporting;Research;Research Project Grants;ribosome profiling;Ribosomes;Role;single molecule;Site;Techniques;The Cancer Genome Atlas;Training;transcriptome sequencing;Translating;Translational Regulation;Translational Repression;Translations;tumor;Untranslated Regions;Untranslated RNA;Vertebrates;Work;Zebrafish

PROJECT_TITLE: Translation of small open reading frames in 3'UTR enhances translation of canonical open reading frames


ED_INST_TYPE: UNIVERSITY-WIDE

ORG_CITY: TALLAHASSEE

ORG_NAME: FLORIDA STATE UNIVERSITY

ORG_STATE: FL

PHR: Word reading disability is the most frequently diagnosed form of learning disability in children, having a major impact on health and quality of life, with effects associated with poor academic achievement, employment prospects, and problems with social relationships. Understanding complex behavioral phenotypes of RD that vary as a function of child experience and cognitive ability across linguistically diverse samples of learners who have been historically under-represented in research on specific learning disabilities is a fundamental step towards improving identification, prevention, and treatment of reading problems. The overarching goal of this LD Hub is to continue to lay the foundation for a generation of research that situates educational practices (e.g., diagnosis, curriculum, instruction, & intervention) in a novel theory of individual word reading development with the knowledge and product generated from this Hub being used to inform future behavioral, computational, and neurobiological studies examining the development of word reading skills and will be used to align theories describing the relations between child- and word-attributes that explain individual differences in word reading more closely with the educational challenges confronting educators of both typically developing (TD) and more specifically children with reading disability (RD), while also expanding our emphasis to assess where important differences exist in under-represented populations in RD research.

PI_NAMEs: COMPTON, DONALD L (contact)

PROGRAM_OFFICER_NAME: MILLER, BRETT

PROJECT_TERMS: Academic achievement;Address;Adopted;African American;Age;Assessment tool;base;Behavioral;behavioral phenotyping;Black race;career;career development;Child;Code;Cognitive;cognitive ability;cognitive skill;Collaborations;Communities;Complex;Data;Data Set;database design;Databases;Development;Diagnosis;Disability research;Disability status;Disabled Persons;Education;education research;Educational Curriculum;Educational Models;Employment;English Language;English Learner;ethnic minority;experience;experimental study;fifth grade;Foundations;frontier;Future;Generations;Goals;Grant;Health;Home;improved;Individual;Individual Differences;Infrastructure;innovation;Institution;Instruction;interdisciplinary approach;Interdisciplinary Study;interest;Intervention;Knowledge;Language;Language Development;Learning;Learning Disabilities;lexical;Linguistics;literacy;member;Methods;Motivation;multidisciplinary;National Institute of Child Health and Human Development;Neurobiology;Neurocognitive;next generation;novel;Performance;Phenotype;phonology;Population;Prevention;programs;Property;Psycholinguistics;public database;Quality of life;racial minority;Reader;Reading;Reading Disabilities;Recruitment Activity;remediation;Research;Research Infrastructure;Research Personnel;Research Project Grants;Sampling;Scientist;Shapes;skills;social relationships;Spanish;Structure;System;Talents;theories;Training;Translational Research;Underrepresented Populations;Validation;virtual experiments;Work;Writing

PROJECT_TITLE: Determinants of phenotypes within the word reading (dis)ability population: The impact of diverse language experiences and child attributes on emerging reading skills


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Rare Diseases;Tuberculosis

ORG_CITY: Newark

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: PROJECT NARRATIVE The proposed research is relevant to human health because Mycobacterium tuberculosis (Mtb) is the number one infectious disease killer in the world. The ability of innate immune cells to kill or control Mtb infection is critical for disease outcomes. Therefore, I aim to understand how this process is regulated in hopes of one day developing therapeutics designed to enhance macrophages' antibacterial responses and control infection in human patients. The proposed research is relevant to the part of NIH's mission that pertains to making fundamental discoveries that will help prevent and treat disease.

PI_NAMEs: BELL, SAMANTHA LYNN (contact)

PROGRAM_OFFICER_NAME: EICHELBERG, KATRIN

PROJECT_TERMS: Affect;Antibacterial Response;Antibiotic Resistance;Automobile Driving;Autophagocytosis;Bacillus;bacterial genetics;Biochemical;Biochemistry;Biological;Biological Process;Biophysical Process;Biophysics;Cell membrane;Cell Nucleus;Cells;Cellular biology;combat;Communicable Diseases;Complex;Cytoplasm;Data;Defense Mechanisms;design;Development;Disease;Disease Outcome;Event;experimental study;fighting;fluorescence imaging;Galactose Binding Lectin;genetic approach;Health;Human;human pathogen;Immune;Immune response;Immune system;In Vitro;in vivo;Individual;Infection;Infection Control;innate immune pathways;Innate Immune Response;innovation;interdisciplinary approach;Knowledge;Link;Liquid substance;live cell imaging;Macrophage;Membrane;Microbiology;Mission;Modification;Molecular;Molecular Biology;Mycobacterium tuberculosis;Natural Immunity;novel;novel therapeutics;optogenetics;Organelles;pathogen;Pathogenesis;Patient-Focused Outcomes;Patients;Persons;Phase;Phenotype;Phosphorylation;Physical condensation;Polyubiquitination;Population;Post-Translational Protein Processing;prevent;Process;Proteins;Proteomics;Reaction;Recording of previous events;Regulation;Reporting;Research;response;Role;Signal Transduction;Stimulator of Interferon Genes;Structure;TBK1 gene;Testing;Therapeutic;tool;Training;Tuberculosis;Ubiquitination;United States National Institutes of Health;Work

PROJECT_TITLE: Investigating the role of liquid-liquid phase separation in the interaction between Mycobacterium tuberculosis and macrophages


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Disability Research;Pediatric

PROJECT_TERMS: Address;Adopted;Affect;African American;base;Behavioral;behavioral phenotyping;career;Characteristics;Child;Code;Cognitive;cognitive ability;cognitive skill;Complex;Computer Models;computerized tools;Data;Databases;Demographic Factors;design;Development;Disability research;Disability status;Disabled Persons;Dyslexia;Early identification;Education;Educational Models;English Language;English Learner;Environment;ethnic minority;experience;Exposure to;Financial Hardship;Foundations;Funding;Future;Generations;Goals;Head;Home;Individual;Individual Differences;innovation;interdisciplinary approach;Intervention;Knowledge;Language;Language Development;Learning;Learning Difficulty;Linguistics;literacy;Measures;Modeling;multidisciplinary;National Institute of Child Health and Human Development;Nature;Neurobiology;novel;Oral;Orthography;Pathway interactions;Phenotype;phonological awareness;phonology;Population;predicting response;Process;Property;Psycholinguistics;public database;Public Health;Race;racial minority;Reader;Reading;reading difficulties;Reading Disabilities;Reporting;Research;Research Infrastructure;Research Personnel;Research Project Grants;response;Risk;Sampling;School-Age Population;Schools;Scientist;Semantics;Shapes;skills;Societies;Spanish;Standardization;Structure;success;System;Testing;theories;Translational Research;Underrepresented Populations;Variant;word learning;Work;Workplace;Writing


NIH_SPENDING_CATS: Ataxia Telangiectasia;Childhood Obesity;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Genetics;Hepatitis;Liver Disease;Neurodegenerative;Obesity;Pediatric;Rare Diseases;Regenerative Medicine

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: Pediatric nonalcoholic fatty liver disease is a major clinical condition since it is most common chronic liver disease in children. New knowledge in disease mechanisms is necessary to understand how liver injury progresses from simple fatty liver to steatohepatitis since this may lead to serious complications, such as cirrhosis, cancer or liver failure. This proposal investigates whether DNA damage response mediated by ataxia telangiectasia mutated gene pathway, which governs major cellular processes, will be altered in pediatric nonalcoholic fatty liver disease – this will allow ways to improve outcomes and health in children.

PI_NAMEs: VISWANATHAN, PREETI  (contact)

PROGRAM_OFFICER_NAME: LOH, KATRINA SHUEH WEN

PROJECT_TERMS: Acceleration;Acetaminophen;Acute Liver Failure;Address;adduct;Adolescence;Adult;Affect;ataxia telangiectasia mutated protein;ATM activation;ATM gene;ATM Signaling Pathway;Automobile Driving;Award;Basic Science;Bioinformatics;Biological Assay;Biopsy;Birth;Body Weight;career development;Cell Cycle;cell growth;cell injury;Cell Physiology;Cell Proliferation;Cell Survival;Cells;Cessation of life;Chemical Injury;Chemicals;Child;Childhood;chronic liver disease;Cirrhosis;Clinic;Clinical;clinical practice;clinical training;cohort;Connexin 43;Development Plans;differential expression;Disease;Disease Management;Disease Progression;DNA;DNA Damage;DNA Double Strand Break;DNA lesion;early childhood;Elements;Environment;epigenomics;Event;Excision;Extramural Activities;Fatty Liver;fetal;fibrogenesis;Fibrosis;Functional disorder;functional genomics;Funding;Genes;Genetic;Genome;genome integrity;Genomic approach;Genomic DNA;Growth;Health;Hepatic;Hepatocyte;High Fat Diet;High Prevalence;Histologic;Human;Impairment;improved outcome;infancy;Inflammation;Inflammatory;Injury;injury and repair;Institution;Investigation;knock-down;Knowledge;Leadership;Lipids;Liver;liver biopsy;liver cell proliferation;Liver Failure;liver inflammation;liver injury;Liver Regeneration;liver repair;Liver Stem Cell;loss of function;Malignant Neoplasms;Mediating;Mentors;Messenger RNA;Metabolic;Metabolism;Mitochondria;Mitochondrial DNA;Modeling;Molecular;Molecular Epidemiology;Molecular Target;mouse model;mRNA Expression;Mus;Natural regeneration;NBS1 gene;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;novel;Nuclear;Obesity;obesity in children;old mice;Oncogenic;Organ;Outcome;Oxidative Stress;Pathway interactions;pediatric non-alcoholic fatty liver disease;Pharmaceutical Preparations;Phase;Phosphotransferases;Physicians;Physiological Processes;Polyploidy;postnatal;Predisposition;Prevalence;Primary carcinoma of the liver cells;Process;progression marker;Protein Kinase;Proteins;Publishing;reconstitution;repaired;Reproducibility;Research;Research Training;response;Risk;Role;Sampling;Scientist;Signal Transduction;simple steatosis;Site;skills;Steatohepatitis;stem cell biology;stem cell population;stem cell survival;stem cells;Stress;TACSTD1 gene;Technology;Testing;Therapeutic;Toxic effect;Toxin;Transforming Growth Factor beta;Translational Research;Tyrosinemias;Work

PROJECT_TITLE: Ataxia Telangiectasia Mutated (ATM)-mediated hepatic DNA damage in pediatric nonalcoholic fatty liver disease


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Disability Research;Neurosciences;Pediatric;Social Determinants of Health

PROJECT_TERMS: Access to Information;Address;Adopted;Affect;base;Behavioral;behavioral phenotyping;Benchmarking;Budgets;career;Characteristics;Child;cognitive ability;cognitive skill;cohort;Communication;Complex;Data;Databases;Decision Making;Development;Diagnosis;Disability research;Disabled Children;Disabled Persons;Discipline;Dyslexia;Education;Educational Curriculum;Educational Models;effective therapy;English Language;English Learner;ethnic minority;experience;Foundations;frontier;Future;Generations;Goals;Individual;Individual Differences;Information Dissemination;innovation;Institution;Instruction;interdisciplinary approach;Interdisciplinary Study;Intervention;Knowledge;Language;Language Development;Leadership;Learning;Learning Difficulty;Linguistics;literacy;Mediating;Methods;Motivation;multidisciplinary;National Institute of Child Health and Human Development;Neurobiology;Neurocognitive;next generation;novel;Orthography;Parents;Performance;Phenotype;phonology;Population;Population Heterogeneity;Postdoctoral Fellow;Process;professor;Property;Protocols documentation;Psycholinguistics;public database;racial minority;Reading;reading difficulties;Reading Disabilities;Regulation;remediation;Research;Research Activity;research and development;Research Infrastructure;Research Personnel;Research Project Grants;Resources;Sampling;Scientist;skills;Students;success;System;Talents;theories;Translational Research;undergraduate student;Underrepresented Populations;Work;Writing


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: SAINT LOUIS

ORG_DEPT: NEUROSURGERY

ORG_NAME: WASHINGTON UNIVERSITY

PHR: Narrative There is a critical need for well-trained neurosurgeon-scientists and neurologist-scientists to conduct basic, clinical, and translational research that will lead to improvements in the treatment or cure of neurological disorders. These individuals occupy a unique space working at the interface between clinical medicine and scientific discovery. The immediate goal of the proposed Washington University in St. Louis Neurosurgery and Neurology Research Education Program is to train neurosurgery and neurology residents in either basic or clinical science research, so as to foster their academic success and development into independent physician-scientists who can further our understanding of the mechanisms, etiology, and treatment of neurological diseases.

PI_NAMEs: ZIPFEL, GREGORY J (contact)

PROGRAM_OFFICER_NAME: WEIGAND, LETITIA ALEXIS

PROJECT_TERMS: Academic Medical Centers;Academic Training;Award;Basic Science;Benchmarking;candidate selection;career;career development;Caring;Clinical;Clinical Medicine;Clinical Research;Clinical Sciences;Communities;Country;Dedications;Development;economic incentive;Education;Education Projects;education research;Ensure;Environment;Etiology;experience;Extramural Activities;Face;Faculty;faculty mentor;Feedback;Fellowship;Fostering;Funding;Future;Future Generations;Goals;Grant;Healthcare;improved;Individual;Infrastructure;innovation;Institution;Instruction;interest;K-Series Research Career Programs;Laboratories;Leadership;medical schools;meetings;member;Mentors;Mentorship;Minority;Monitor;National Institute of Neurological Disorders and Stroke;Nervous System Disorder;Neurologic;Neurologist;Neurology;Neurosciences;Neurosciences Research;Neurosurgeon;neurosurgery;next generation;Outcome Measure;Participant;Patients;Physicians;Positioning Attribute;Preparation;Private Practice;Process;Program Evaluation;programs;Qualifying;Records;recruit;Research;Research Personnel;Research Support;Research Training;Residencies;Resources;responsible research conduct;Science;Scientist;Secure;Series;Structure;success;Time;Training;Translational Research;United States National Institutes of Health;Universities;Washington;Woman

PROJECT_TITLE: Washington University Neurosurgery Resident Research Education Program


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Patient Safety;Pediatric;Pediatric Cancer;Racial and Ethnic Minority Health Research;Rare Diseases;Social Determinants of Health

ORG_CITY: LA JOLLA

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE Hispanic children with cancer are significantly underrepresented in cancer clinical trials, therefore there is an urgent need to identify effective interventions to overcome low clinical trial participation to equitably benefit Hispanics. Our long-term goal is to implement generalizable, targeted, effective, and reproducible peer navigation interventions to enhance minority accrual to clinical trials and our overarching objective for this R01 is to increase clinical trial accrual in Hispanic children with cancer by improving research literacy in their parents in a Hybrid randomized clinical trial to both test COMPRENDO (ChildhOod Malignancy Peer REsearch NavigatiOn) peer navigation effectiveness and explore multisite implementation determinants. COMPRENDO has the potential to increase clinical trial accrual in Hispanics across the age continuum, enabling the equitable translation of discoveries and therapies, which is a top priority for NCI.

PI_NAMEs: ARISTIZABAL, PAULA  (contact)

PROGRAM_OFFICER_NAME: CHOU, WEN-YING

PROJECT_TERMS: Address;Administrator;Age;Alabama;Area;Award;California;cancer clinical trial;cancer diagnosis;care delivery;Cause of Death;Child;Childhood;Clinical;clinical trial enrollment;Clinical Trials;Collaborations;Comprehension;Data;Decision Making;Disease;disparity reduction;Education;effective intervention;Effectiveness;effectiveness testing;effectiveness/implementation hybrid;Equity;Ethics;ethnic disparity;evidence base;Exploration, Preparation, Implementation, and Sustainment;Feasibility Studies;Feeling;Future;Goals;health disparity;health literacy;Hispanic;Hispanic Populations;hybrid type 1 design;Hybrids;implementation determinants;implementation evaluation;implementation outcomes;implementation science;implementation/effectiveness;improved;Incidence;infancy;Inferior;Informed Consent;innovation;Intervention;Knowledge;Language;Link;literacy;Malignant Childhood Neoplasm;Malignant Neoplasms;Measures;Methodology;Methods;Minority;Modeling;Newly Diagnosed;Not Hispanic or Latino;novel;Oncologist;Oncology;Outcome;Parents;patient navigation;peer;Population;Population Heterogeneity;pressure;Proctor framework;Provider;racial disparity;Randomized;randomized, clinical trials;Regrets;Reporting;Reproducibility;Research;Sampling;San Francisco;satisfaction;scale up;Self Efficacy;Site;Survival Rate;Testing;Therapeutic Clinical Trial;Time;Training;Translations;treatment as usual;trial comparing;United States National Institutes of Health;Universities;willingness

PROJECT_TITLE: Multisite Implementation of COMPRENDO (ChildhOod Malignancy Peer REsearch NavigatiOn) to improve participation of Hispanic children in cancer clinical trials

STUDY_SECTION: HHD

STUDY_SECTION_NAME: Healthcare and Health Disparities Study Section[HHD]


ADMINISTERING_IC: NR

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Genetics;Human Genome;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention

ORG_CITY: CORAL GABLES

ORG_NAME: UNIVERSITY OF MIAMI CORAL GABLES

PHR: PROJECT NARRATIVE Children born extremely preterm exhibit much higher rates of cognitive function impairment during early childhood through adulthood than those born full term. We propose to examine relationships among gene variants, DNA methylation, neonatal inflammation, and developmental trajectories of cognitive function in extremely preterm children ages 2-17 years. This study will be among the first to identify genetic and epigenetic factors that can be used for risk stratification, as well as molecular processes that can be the targets of early risk-mitigating interventions to improve quality of life for children born extremely preterm.

PI_NAMEs: SANTOS, HUDSON  (contact)

PROGRAM_OFFICER_NAME: AKUBU-ODERO, MAUREEN KALAMBU

PROJECT_TERMS: 15 year old;17 year old;Address;Adolescence;Adult;Age;Biological Specimen Banks;Birth;Blood specimen;Child;Childhood;Chronic Disease;clinical practice;Cognition;Cognitive;cognitive function;cohort;Data;Development;Distress;DNA Methylation;early childhood;Early Intervention;early screening;Epigenetic Process;Exhibits;extreme prematurity;Extremely low gestational age newborn;Family;FK506 binding protein 5;follow-up;gene interaction;Genes;Genetic;Genetic Polymorphism;Genetic study;genetic variant;Genomics;Genotype;Goals;HDAC4 gene;Immune;immune activator;Immune response;Immunologic Factors;Impaired cognition;Impairment;improved;Individual;Infant;Inflammation;innovation;Intervention;Link;Mediating;Mediation;Methylation;Molecular;Neonatal;neurodevelopment;Neurodevelopmental Impairment;Pathway interactions;Pattern;Perinatal;Personal Satisfaction;personalized intervention;Placenta;Predictive Factor;Pregnancy;preterm newborn;prevent;Preventive therapy;Process;Quality of life;Research;Risk;risk mitigation;risk stratification;Sampling;Schedule;Science;Shapes;Smoking;Source;Specimen;Stress;Survival Rate;Umbilical cord structure;whole genome;Work

PROJECT_TITLE: Genetic and Epigenetic Effects on Childhood Cognitive Trajectories