ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Opioid Misuse and Addiction;Opioids;Patient Safety;Pediatric;Substance Misuse

ORG_CITY: LOUISVILLE

ORG_NAME: USWM, LLC

ORG_STATE: KY

PHR: PROJECT NARRATIVE: The nation’s opioid epidemic has remained a public health emergency since 2017, with a steady increase in opioid misuse and deaths among Americans, including adolescents, a particularly underserved opioid use disorder (OUD) population due in part to a lack of approved medications. The proposed research program will enable submission of a supplemental new drug application for Lucemyra (lofexidine), currently FDA approved for opioid withdrawal in adults, to expand approval to adolescents and presenting a treatment option to facilitate patient engagement in therapy and transition to longer term maintenance treatments such as buprenorphine or extended-release naltrexone, as recommended by current adolescent treatment guidelines. Extrapolation of adult efficacy to the adolescent population permits an efficient regulatory path for this work, with two studies planned to complete registration requirements: i) a pharmacokinetic study in adolescents to identify doses producing lofexidine blood concentrations associated with efficacy in adults, and ii) an open label safety study to complete an adequate safety package for approval in adolescents.

PI_NAMEs: MASSEY, VERONICA LYNCH;SCHMIDT, LEE  (contact)

PROGRAM_OFFICER_NAME: SEYMOUR, KAREN ELIZABETH

PROJECT_TERMS: Acceleration;Acute;Adolescent;Adolescent Development;adolescent patient;Adrenergic Agonists;Adult;Adverse event;Affect;Age;aged;American;Benefits and Risks;Biological Assay;Blood;Blood Pressure;Body Weight;Buprenorphine;Cessation of life;Child;Childhood;Clinical;Collaborations;Data;Data Analyses;Data Pooling;Databases;design;Development;Development Plans;Diagnosis;Dose;Drug Kinetics;effective therapy;effectiveness evaluation;effectiveness measure;Electrocardiogram;experience;Exposure to;Face;follow-up;General Population;Goals;Guidelines;Health Services Accessibility;Heart Rate;Intervention;Label;lofexidine;Maintenance;Measures;medication for opioid use disorder;meetings;Modeling;Naltrexone;National Institute of Drug Abuse;novel therapeutics;off-label use;open label;Opiate Addiction;Opioid;opioid abuse;opioid epidemic;opioid misuse;opioid mortality;opioid overdose;opioid use disorder;opioid withdrawal;participant enrollment;patient engagement;patient population;Patients;Pharmaceutical Preparations;pharmacokinetic model;Pharmacotherapy;Phase;phase 1 study;Plasma;Population;Program Development;programs;public health emergency;Recommendation;Reference Values;Regulatory Pathway;Research;respiratory;Risk Assessment;Safety;safety assessment;safety study;Sampling;Severities;Suicide;Tablets;treatment guidelines;treatment response;treatment strategy;trend;United States Food and Drug Administration;Visit;Withdrawal Symptom;Work

PROJECT_TITLE: Registration Development Program for LUCEMYRA (Lofexidine) Label Expansion for Opioid Withdrawal Treatment in Adolescents

STUDY_SECTION: NIDA

STUDY_SECTION_NAME: Medication Development Research Study Section[NIDA-L]


ADMINISTERING_IC: EY

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision

ORG_CITY: Columbus

ORG_COUNTRY: UNITED STATES

ORG_DEPT: OPHTHALMOLOGY

ORG_FIPS: US

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative No change from original proposal.

PI_NAMEs: MOROI, SAYOKO E (contact)

PROGRAM_OFFICER_NAME: GOVER, TONY DOUGLAS

PROJECT_TITLE: Ohio State University Vision Sciences Research Core Program


ADMINISTERING_IC: NS

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Biomedical Imaging;Brain Disorders;Clinical Research;Emergency Care;Epilepsy;Neurodegenerative;Neurosciences;Pediatric;Prevention

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Narrative Childhood status epilepticus (SE) is a common life-threatening emergency, with a high risk of death and high risk of disability among survivors. This large cohort study of children with SE in northern Nigeria will determine the phenotypes of childhood SE, clinical and genomic predictors of SE resistance to specific first-line drugs (benzodiazepines), clinical and genomic predictors of SE outcome (death and disability), and clinical and genomic predictors of epilepsy among children who survive SE as their first seizure. This research may lead to a better understanding of this cause of childhood death and disability, informing future improved strategies for treatment and prevention.

PI_NAMEs: SABO, UMAR ABBA;TREVATHAN, EDWIN  (contact)

PROGRAM_OFFICER_NAME: HARTMAN, ADAM L

PROJECT_TERMS: Academic Medical Centers;Accident and Emergency department;Africa South of the Sahara;African;Benzodiazepines;Biological Sciences;brain magnetic resonance imaging;Caring;Cessation of life;Child;Childhood;Clinical;clinical predictors;clinical risk;cohort;Cohort Studies;Collaborations;Community Health;Development;disability;disability risk;Electroencephalography;Emergency Situation;Epilepsy;experience;Future;Gender;genome wide association study;genomic predictors;Genomics;high risk;Hospitals;human disease;improved;Incidence;innovation;insight;Life;low and middle-income countries;magnetic resonance imaging/electroencephalography;Molecular;Morbidity - disease rate;mortality;mortality risk;Neurological emergencies;Nigeria;Outcome;pediatric emergency;Pharmaceutical Preparations;Phenotype;point of care;Prevention;Recording of previous events;Research;Resistance;Risk;Risk Factors;Seizures;South Africa;Specialist;Status Epilepticus;Survivors;Teaching Hospitals;Technology;Training;treatment strategy;Universities

PROJECT_TITLE: Childhood Status Epilepticus and Epilepsy Determinants of Outcome (SEED) – EEG and MRI Supplement

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(57)-R]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Infectious Diseases;Microbiome;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE Vibrio cholerae is the etiologic agent of the severe human diarrheal disease cholera, which is responsible for severe morbidity and mortality in developing countries around the world. These proposed studies will characterize Vibrio cholerae-gut microbiome interactions in the protective mucus layer of the gut during V. cholerae infection, with the goal of better understanding how V. cholerae using intestinal mucin to promote pathogenesis and interactions with resident microorganisms and the host, and, potentially, discovering novel therapeutic and prophylactic interventions for cholera.

PI_NAMEs: HSIAO, ANSEL ;ZHU, JUN  (contact)

PROGRAM_OFFICER_NAME: ZEITUNI, AMIR E

PROJECT_TERMS: Area;Automobile Driving;Carbon;Cells;Characteristics;Cholera;Communities;Developing Countries;diarrheal disease;Disease Outcome;disease phenotype;dysbiosis;enteric infection;Epithelial Attachment;Epithelial Cells;Epithelium;Etiology;fitness;Glycoproteins;Gnotobiotic;Goals;Growth;gut microbes;gut microbiome;gut microbiota;host-microbe interactions;Human;Human Characteristics;in vivo;Individual;Infection;Intervention;Intestines;Mediating;member;Metabolic;Metabolism;Metalloproteases;Microbe;microbial community;microbiota;microorganism;microorganism interaction;Modeling;Morbidity - disease rate;mortality;Mucin-2 Staining Method;mucinase;Mucins;Mucolytics;Mucous body substance;Mucous Membrane;Mus;mutant;novel therapeutics;Outcome;pathogen;Pathogenesis;Penetration;Predisposition;Production;Proliferating;prophylactic;Proteins;Resistance;Resistance to infection;Role;Site;Small Intestines;Source;Specificity;Structure;Surface;Testing;tissue culture;Variant;Vibrio cholerae;Vibrio cholerae infection;Virulence;Virulence Factors

PROJECT_TITLE: The role of a bifunctional mucinase in modulating personalized gut microbiota-Vibrio cholerae interactions during infection


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Autism;Brain Disorders;Genetics;Intellectual and Developmental Disabilities (IDD);Maternal Health;Maternal Morbidity and Mortality;Mental Health;Pediatric;Pregnancy;Prevention;Women's Health Research

ORG_CITY: NEW YORK

ORG_DEPT: PSYCHIATRY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: We will perform first systematic test of associations between maternal diagnoses around pregnancy and the risk of ASD in offspring. In order to understand whether the observed associations between maternal diagnoses and ASD arise due to genetic or non-genetic mechanisms, we will then analyze family and molecular genetic data available for this large cohort. Our goal is to identify potential novel risk factors for ASD, close important gaps in the knowledge about the etiology of ASD, and elucidate possible pathways to prevention.

PI_NAMEs: JANECKA, MAGDALENA  (contact)

PROGRAM_OFFICER_NAME: PEVSNER, JONATHAN ABRAM

PROJECT_TERMS: Accounting;Affect;American;autism spectrum disorder;autistic children;Birth;Brothers;California;Child;Circulation;cohort;comorbidity;Coupled;Data;Data Set;Data Sources;Denmark;design;Development;Diabetes Mellitus;Diagnosis;Disease;disorder risk;Early identification;Ensure;Environmental Risk Factor;Epidemiology;Etiology;experience;Exposure to;Extended Family;Family;family genetics;Family Relationship;Female;Fetus;Genetic;genetic pedigree;Genetic Risk;Goals;Health Status;high risk;indexing;Individual;Infection;innovation;insight;Intellectual functioning disability;International Statistical Classification of Diseases and Related Health Problems, Tenth Revision (ICD-10);Intervention;Knowledge;Link;Live Birth;male;Maps;Maternal Exposure;Maternal Health;Medical;Medical Records;Mental Depression;Methodology;modifiable risk;Molecular Genetics;Mothers;non-genetic;novel;offspring;Outcome;Output;Parents;Partner in relationship;Pathway interactions;Permeability;Placenta;polygenic risk score;population based;Pregnancy;prenatal;Prevention;Preventive;Process;Public Health;recurrent infection;Registries;response;Risk;Risk Factors;Sampling;sex;Sister;Testing;Time;transmission process;Vertical Disease Transmission;Woman;Work

PROJECT_TITLE: Maternal health in pregnancy and autism risk - genetic and non-genetic mechanisms

STUDY_SECTION: BGES

STUDY_SECTION_NAME: Behavioral Genetics and Epidemiology Study Section[BGES]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Aging;Clinical Research;Immunization;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza;Prevention

ORG_CITY: KALAMAZOO

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: WESTERN MICHIGAN UNIV SCHOOL OF MEDICINE

ORG_STATE: MI

PHR: PROJECT NARRATIVE B1 lymphocytes mediate the immune response to infection, providing immediate and essential protection against Streptococcus pneumoniae, which in both human and murine systems infection disproportionally effects the aging population, claiming the lives of people over 65 eight times more frequently than others. B1 cells maintain themselves through a unique self-renewal process and provide pneumococcal protection through production of natural antibody; however, our results demonstrate natural antibody obtained from aged males does not provide protection against S. pneumoniae while natural antibody from aged females does maintain protective capacity. This project will determine the role sex plays in the ability of B1 cells to maintain self-renewal into old age and subsequently produce protective natural antibodies.

PI_NAMEs: WEBSTER, SARAH E (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Adult;Age;age effect;age group;age related changes;aged;Aging;aging population;Anatomy;Antibodies;Antibody Formation;Apoptotic;Autoimmune Diseases;B-Cell Development;B-Lymphocyte Subsets;B-Lymphocytes;Bacteria;Binding;Blood Vessels;Bone Marrow;Cause of Death;CD86 gene;Cell Aging;Cell Cycle;Cell Maintenance;Cells;Cessation of life;Characteristics;Data;Development;Disease;DNA Nucleotidylexotransferase;Encapsulated;Enzymes;expression cloning;Female;fetal;Fetal Development;fighting;Frequencies;Generations;Genes;Germ Lines;Goals;Greater sac of peritoneum;Hematopoietic stem cells;Homeostasis;Human;human old age (65+);IL2RA gene;Immune;Immune response;Immune system;Immunization;Immunoglobulin A;Immunoglobulin Genes;Immunoglobulin M;Incidence;Individual;Infection;Infection prevention;Life;Location;Lower Respiratory Tract Infection;Lymphocyte;Maintenance;male;Mediating;microbial;Mus;natural antibodies;Natural Immunity;Neonatal;pathogen;Persons;Phenotype;Play;Pneumococcal Infections;Pneumonia;Population;Predisposition;Prevention strategy;Process;Production;Productivity;Recording of previous events;Regulation;Reporter Genes;response;Role;self-renewal;Serum;sex;Sex Differences;Source;Spleen;stem;stem cell function;stem cell niche;Streptococcus pneumoniae;Structure;System;Testing;Time;Transgenic Organisms;treatment strategy;Vaccines;Vulnerable Populations;Work

PROJECT_TITLE: Sex Specific Regulation of B1 B Cell Self-Renewal and Natural Antibody Production


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: DALLAS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: PROJECT NARRATIVE Chronic renal inflammation causes hypertension and therefore should be targeted. Normally, neuro-immune mechanisms like the cholinergic anti-inflammatory pathway regulate inflammation but when this nerve-to-spleen communication is impaired, this can lead to excessive inflammation. The proposed studies will dissect neural and local contributions of the cholinergic anti-inflammatory pathway and determine its role in regulating renal inflammatory responses that if left unabated can foster hypertension.

PI_NAMEs: MATHIS, KEISA WILLIAMS (contact)

PROGRAM_OFFICER_NAME: VARAGIC, JASMINA

PROJECT_TERMS: Acceleration;Acetylcholine;Acetylcholinesterase;Acetylcholinesterase Inhibitors;Acute;Adoptive Transfer;Adult;Affect;Anti-Hypertensive Agents;Anti-Inflammatory Agents;Applications Grants;Autoimmune;Autoimmune Diseases;Autonomic Dysfunction;Biological Availability;Blood Pressure;blood pressure reduction;Cardiovascular Diseases;cardiovascular risk factor;Cell Nucleus;Cells;cholinergic;Chronic;chronic inflammatory disease;Chronic Kidney Failure;Communication;cost;Data;Dementia;designer receptors exclusively activated by designer drugs;Development;Disease;disease model;dorsal motor nucleus;efficacy evaluation;FDA approved;Fostering;Galantamine;Ganglionectomy;Genetic;Guidelines;Health;healthcare burden;Hypertension;hypertensive;Immune;immune function;Immune response;immunoregulation;Impairment;In Vitro;Inflammation;Inflammatory;Inflammatory Response;innovation;Kidney;Left;Measures;Mental Depression;Methods;Modality;Modeling;Monitor;mouse model;Mus;nanoparticle;Nerve;neural;neural circuit;Neuroimmune;Neuroimmunomodulation;Neurons;neurotransmission;new therapeutic target;novel;Operative Surgical Procedures;Organ;Pathogenesis;Pathway interactions;Patients;Peripheral;Persons;pharmacologic;Physiology;prevent;protective pathway;Publishing;Regulation;Resistance;resistance mechanism;Resistant Hypertension;Role;Spleen;Splenectomy;Sympathectomy;System;Systemic Lupus Erythematosus;T-Lymphocyte;targeted delivery;Techniques;Technology;Therapeutic;therapeutically effective;therapy resistant;Vagotomy;vagus nerve stimulation;Vagus nerve structure;Work

PROJECT_TITLE: Control of Renal Inflammation in Hypertension

STUDY_SECTION: HM

STUDY_SECTION_NAME: Hypertension and Microcirculation Study Section[HM]


NIH_SPENDING_CATS: Attention Deficit Hyperactivity Disorder (ADHD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Mental Health;Neurofibromatosis;Neurosciences;Pediatric;Rare Diseases

ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: PROJECT NARRATIVE Neurofibromatosis type 1 (NF1) is one of the most common genetic disorders worldwide, with no curative treatment for its many symptoms: neurocutaneous lesions, developmental disorders, and tumors. One of the most substantial concerns for NF1 patients are the cognitive symptoms of attention deficit hyperactivity disorder (ADHD) which has significant adverse consequences in learning, social interaction, and later adult life. This project will increase our understanding of ADHD behaviors, and will propose a new treatment target for NF1 that has the potential to treat this disabling syndrome.

PI_NAMEs: DROZD, HAYLEY P (contact)

PROGRAM_OFFICER_NAME: DRISCOLL, JAMIE DANIELLE

PROJECT_TERMS: Address;Adolescent;Adult;adverse outcome;Affect;Attention deficit hyperactivity disorder;Attentional deficit;autism spectrum disorder;autosome;Behavior;behavioral impairment;Behavioral inhibition;behavioral study;beta-Transducin Repeat-Containing Proteins;Biological Models;boys;Brain;brain circuitry;Clinical;clinically relevant;Cognition;Cognitive deficits;Complex;CREB1 gene;Cullin Proteins;curative treatments;Data;Development;developmental disease;Diagnosis;Disabling;discounting;Disease;Drug toxicity;Drug usage;Exhibits;experience;Experimental Models;falls;Female;Female Adolescents;Frequencies;Functional disorder;General Population;Genes;Genetic;Genetic Diseases;girls;Guanfacine;Hereditary Disease;Hyperactivity;improved;in vivo;Incidence;Individual;knock-down;Learning;Learning Disabilities;Lesion;Life;male;Male Adolescents;MAP Kinase Gene;Measures;Memory impairment;Methodology;Molecular;multicatalytic endopeptidase complex;Mus;Mutation;Neurobehavioral Manifestations;Neurobiology;Neurofibromatosis 1;Neurons;new therapeutic target;NF1 gene;novel;novel strategies;Pathway interactions;Patients;Pharmaceutical Preparations;pharmacologic;Phosphorylation;polypeptide;pre-clinical;Prefrontal Cortex;prepulse inhibition;Prevalence;Proteins;ras GTPase-Activating Proteins;Reaction;Recycling;Rewards;Role;sex;social;Social Interaction;social learning;Study models;Symptoms;Syndrome;Testing;therapeutic target;Time;Transducin;translational therapeutics;tumor;Ubiquitin;ubiquitin-protein ligase;Ubiquitination;Work

PROJECT_TITLE: Molecular Mechanisms of ADHD in Neurofibromatosis Type 1


ADMINISTERING_IC: DC

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

ORG_NAME: MONELL CHEMICAL SENSES CENTER

PHR: Project Narrative Monell’s Postdoctoral Training Program provides the tools for young scientists to gain independence—a high- yield scientific environment, committed faculty, and coursework in a range of biomedical research areas, including the responsible conduct of research. Under this proposal, Vicente Ramirez, a Hispanic U.S. Citizen, will receive training as outlined in the parent T32 award, to contribute intellectually to the research on surveillance of smell function in the general population, which will enhance his knowledge of chemosensation by extending it to olfaction and contribute to his development as a chemosensory researcher.

PI_NAMEs: DALTON, PAMELA HELEN;MAINLAND, JOEL D (contact);REED, DANIELLE RENEE

PROGRAM_OFFICER_NAME: RIVERA-RENTAS, ALBERTO L

PROJECT_TERMS: Administrative Supplement

PROJECT_TITLE: Diversity Administrative Supplement to T32DC000014


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Aging;Biodefense and Related Countermeasures;Burden of Illness;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Data Science;Emerging Infectious Diseases;Health Services;Infectious Diseases;Networking and Information Technology R&D (NITRD)

ORG_CITY: HOLLAND

ORG_NAME: AQUORA RESEARCH AND CONSULTING LLC

PHR: Project Narrative As the world returns to a new normal, post-COVID19 pandemic, there is a widely accepted need to improve technologies to anticipate future viral outbreaks due to endemic viral pathogens, especially among the most at- risk and vulnerable citizens. Building off our highly successful Phase I project, we will use predictive statistical modelling using wastewater to anticipate the timing and severity of future outbreaks from SARS-CoV-2, Influenza, RSV and Norovirus within high risk, older residents residing in long-term care facilities. This project is focused on establishing the quality and usability of next-generation statistical models to anticipating outbreaks, and modify LTCF infectious disease practices as a practical and cost-saving approach for heading off future viral outbreaks.

PI_NAMEs: BEST, AARON ADDISON (contact)

PROGRAM_OFFICER_NAME: BOZICK, BROOKE ALLISON

PROJECT_TERMS: 2019-nCoV;acute COVID-19;advocacy organizations;Aging;Assisted Living Facilities;Behavior;Benchmarking;burden of illness;Caring;catalyst;Client;commercialization;Communicable Diseases;Communities;Computerized Medical Record;Cost Savings;COVID-19;COVID-19 monitoring;COVID-19 outbreak;COVID-19 pandemic;dashboard;Data;data integration;data modeling;Data Science;design;detection assay;Diagnosis;Disease;disease model;Disease Outbreaks;disorder control;economic cost;economic impact;Economics;Elderly;Ensure;Epidemic;flexibility;Funding;Future;future outbreak;global health;Growth;Health;Health Care Costs;Health care facility;high risk;Home;Human;improved;Individual;Industry;Influenza;Innovation Corps;Investments;Lead;Location;Long-Term Care;Machine Learning;Marketing;Modeling;Monitor;next generation;Norovirus;novel;Outcome;pandemic disease;pathogenic virus;Pathway interactions;Phase;Population;Positioning Attribute;post-COVID-19;predictive modeling;programs;Research;Risk;risk mitigation;Sampling;Scientist;Services;Severities;Sewage;Signal Transduction;Skilled Nursing Facilities;Small Business Innovation Research Grant;Societies;statistical learning;Statistical Models;Technology;Testing;Time;Training;United States National Institutes of Health;Urbanicity;usability;Validation;Viral;viral outbreak;Vulnerable Populations;wastewater epidemiology;wastewater monitoring;wastewater sampling;Work

PROJECT_TITLE: Wastewater data integration and modelling to accurately predict viral outbreaks in long-term care facilities

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 HSS-J (10)]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Mental Health;Neurodegenerative;Neurosciences;Patient Safety;Prevention;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: PROVIDENCE

ORG_NAME: RHODE ISLAND HOSPITAL

ORG_STATE: RI

PHR: Project Narrative The proposed research is important because older adults undergo more major surgeries than any other sector of the U.S. population and are substantially more likely to experience delayed or incomplete cognitive recovery than younger patients; however, there are no known effective preventative or treatment strategies for postoperative delirium and postoperative cognitive dysfunction. This research is relevant to public health because it is expected to increase understanding of the underlying reasons for these harmful and costly events, and will lay essential groundwork for development of future interventions to improve the cognitive safety of major surgery for older adults.

PI_NAMEs: DAIELLO, LORI A (contact)

PROGRAM_OFFICER_NAME: ROBERTS, LUCI

PROJECT_TERMS: Acute;aging brain;aging population;Albumins;Animal Model;Area;Attention;Benign;Biological Markers;Blood;Blood - brain barrier anatomy;Blood brain barrier dysfunction;blood-brain barrier disruption;blood-brain barrier permeabilization;Brain;Brain imaging;Cardiac Surgery procedures;Cerebrovascular Disorders;Chronic Disease;Circulation;Cognition Disorders;Cognitive;cognitive function;cognitive recovery;cost;Day Surgery;Delirium;dementia risk;Development;Diabetes Mellitus;Disease;endothelial dysfunction;Endothelium;Event;experience;Failure;follow-up;Future;Genetic Risk;Goals;Growth;Health;Hospitalization;human old age (65+);Image;Imaging Techniques;Impaired cognition;Impairment;improved;Incidence;indexing;Inflammation;inflammatory marker;Inflammatory Response;Injury;innovation;inpatient surgery;insight;Intervention;Knowledge;Learning;Link;Longitudinal Studies;Magnetic Resonance Imaging;Maps;Measures;Memory;Modeling;neurocognitive disorder;neuroimaging;neuroinflammation;Neurons;neurovascular;Nursing Homes;older adult;older patient;Operative Surgical Procedures;Outcome;Patients;Perioperative;Peripheral;peripheral blood;Permeability;Physical Function;physical impairment;Population;post-operative cognitive dysfunction;postoperative delirium;Postoperative Period;Predisposition;premature;prevent;Prevention strategy;Preventive treatment;Procedures;prognostic;Public Health;Quality of life;Radioactive;readmission risk;Reporting;Research;Retirement;Risk;Risk Factors;Role;Safety;Serum;Stress;Structure;Surgical complication;Technology;Testing;Toxin;treatment strategy;United States;Water;Work

PROJECT_TITLE: Blood-Brain Barrier Disruption as a Biomarker for Perioperative Neurocognitive Disorder:Cognitive Recovery after Elective Surgery


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Physical Injury - Accidents and Adverse Effects;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE Loneliness, a discrepancy between actual and desired social connection, detrimentally impacts physical and mental well-being and is comparable to well-known risk factors for mortality. Sexually minoritized men are more likely to experience loneliness, which some people may manage through increased substance use or riskier sexual behaviors, thus heightening HIV risk. Using two longitudinal cohorts composed of sexually minoritized men and gender-expansive groups from Chicago, IL, and Vancouver, Canada, this dissertation proposal will: 1) examine the relationship between loneliness, substance use (drug, alcohol, and polysubstance use), and HIV prevention and 2) elucidate the role of loneliness on non-fatal overdose and HIV risk through linked survey and administrative health data.

PI_NAMEs: MARZIALI, MEGAN ELYSSA (contact)

PROGRAM_OFFICER_NAME: DUNSTON, SHEBA KING

PROJECT_TERMS: Accident and Emergency department;Accounting;Address;Adherence;Adverse effects;adverse event risk;Affect;AIDS prevention;Alcohol consumption;Anti-Retroviral Agents;Area;Bisexual;Black race;Canada;Caring;Characteristics;Chicago;cohort;Coin;Communities;contagion;Country;Data;Data Collection;Data Linkages;Death Rate;Drug usage;Drug user;Epidemic;Epidemiology;ethnic disparity;Ethnic Origin;experience;Feeling;Frequencies;Future;Gays;Gender expansive;Goals;Health;health data;Heterosexuals;high risk sexual behavior;HIV;HIV Infections;HIV risk;Illinois;improved;indexing;Individual;Inequity;Inpatients;Institution;interest;Intervention;Knowledge;Link;Literature;Loneliness;Longitudinal cohort;Measures;Mediator;member;men;Mental Depression;Mentored Research Scientist Development Award;Mentorship;mortality;National Institute of Drug Abuse;Neighborhoods;opioid overdose;Outcome;Overdose;overdose death;overdose risk;Participant;Pathway Analysis;Pattern;person centered;Persons;Policies;Policy Maker;polysubstance use;pre-exposure prophylaxis;Prevalence;prevent;Prevention strategy;Principal Investigator;Prospective, cohort study;Qualitative Research;Race;racial disparity;recruit;Reporting;Research;Research Personnel;Research Priority;Respondent;Risk;Risk Factors;Role;Sampling;Severities;sexual minority men;social;social factors;Social isolation;Social Network;Specific qualifier value;Stimulant;Strategic Planning;substance use;Substance Use Disorder;substance use prevention;Surgeon;Surveys;theories;transmission process;United States;Well in self

PROJECT_TITLE: Dissecting the role of loneliness on substance use- and HIV-related outcomes among sexual minority men in the United States and Canada

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F17B-K (20)]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: ANN ARBOR

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: PROJECT NARRATIVE This program focuses on developing new synthetic methods for the construction and late-stage diversification of biologically relevant molecules. Specifically, it leverages the PI's expertise in synthetic methods development, physical organic chemistry/mechanistic analysis, and organometallic chemistry to address important challenges in the areas of transition metal-catalyzed C–H functionalization and cross-coupling reactions.

PI_NAMEs: SANFORD, MELANIE S. (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TERMS: Address;Area;base;Carbon;Carboxylic Acids;catalyst;chemical reaction;Chemicals;Complex;Coupling;Data;design;Development;drug candidate;Fluorine;Foundations;functional group;Goals;Hydrogen Bonding;interest;invention;Metals;method development;Methods;Modernization;next generation;novel strategies;Organic Chemistry;Organic Synthesis;Organometallic Chemistry;Pharmaceutical Chemistry;programs;Reaction;Site;Structure;Transition Elements;Work

PROJECT_TITLE: Metal-Catalyzed Reactions for Organic Synthesis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-B(55)R]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

PHR: Project Narrative Sustained, continuous access to perinatal insurance is critical to maternal health and health equity, yet under longstanding federal law, pregnancy-related Medicaid coverage is only guaranteed through 60-days postpartum. As a result, estimates suggest ~45% of birthing people with Medicaid and CHIP lose coverage after 60 days; many state legislatures and Medicaid programs have passed or are considering passing legislation to extend coverage, but their policy approaches vary. Our project will evaluate the impacts of postpartum Medicaid policy on maternal health equity using an adaptive concurrent mixed-methods approach, and our findings will provide timely insights for policymakers and stakeholders working to improve maternal health outcomes.

PI_NAMEs: JANEVIC, TERESA  (contact)

PROGRAM_OFFICER_NAME: OLADEINDE, YEWANDE A

PROJECT_TERMS: Address;Adopted;Adoption;American;Birth;Black Populations;Black race;Communities;community organizations;Community Surveys;Contraceptive methods;Coronavirus;Country;Data;Death Rate;design;Diabetes Mellitus;Dimensions;Eligibility Determination;Enrollment;Environment;Equity;ethnic disparity;Exclusion;Exclusion Criteria;Face;Family;follow-up;Goals;health care service utilization;health equity;Health Personnel;Health Policy;Healthcare;Hypertension;Immigrant;improved;Income;Inequity;insight;Institution;Insurance;Interruption;Interview;Laws;Legal;Length;lens;Maternal Health;Maternal health equity;maternal morbidity;Maternal Mortality;Measures;Medicaid;Medicaid eligibility;Mental Health;Methods;Modeling;Neighborhoods;New York;Outcome;pandemic disease;Perinatal;perinatal complications;perinatal health;Persons;Policies;Policy Maker;post implementation;post-pandemic;postpartum health;Postpartum Period;Postpartum Women;pragmatic implementation;pre-pandemic;Pregnancy;pregnant;primary outcome;programs;Provider;racial disparity;Recommendation;Reduce health disparities;Research Priority;Resources;response;Risk;Role;Series;Shapes;Statutes and Laws;Structural Racism;Targeted Research;Texas;Time;Variant;Visit;waiver

PROJECT_TITLE: Evaluating Medicaid Postpartum Coverage Extensions through and Equity Lens

STUDY_SECTION: ODHS

STUDY_SECTION_NAME: Organization and Delivery of Health Services Study Section[ODHS]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Genetics;Hematology;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: NARRATIVE The proposed research is relevant to public health because it will expand fundamental knowledge of the molecular factors, in particular the interferon-regulatory factor-4 (IRF4) pathway, that govern malignant stem cell generation in multiple myeloma, the second most common blood cancer in the United States. This proposal requests additional funds for laboratory staff salaries, small equipment, and near-term publication costs to offset additional funds expended during a critical life event of the PI and support the continued success of the parent award project. This overall effort is relevant to NIH’s mission because it will test novel combination drug treatment strategies that have high potential to help reduce illness and disability for patients with multiple myeloma.

PI_NAMEs: CREWS, LESLIE A (contact)

PROGRAM_OFFICER_NAME: HOWCROFT, THOMAS K

PROJECT_TERMS: Acceleration;adenosine deaminase;Administrative Supplement;Antibody-Producing Cells;Antisense Oligonucleotide Therapy;Antisense Oligonucleotides;B-Lymphocytes;Biological Markers;Bone Marrow;Bortezomib;burden of illness;cancer stem cell;Cell Survival;Cell Transplantation;Cells;Clinical;clinical translation;Combined Modality Therapy;cost;cytokine;Detection;Development;disability;Double-Stranded RNA;Drug Combinations;Drug resistance;Drug usage;Ensure;Equipment;Event;Funding;Gene Expression;Generations;Genes;Genetic;Genetic Transcription;Growth Factor;Hematopoietic Neoplasms;Hematopoietic stem cells;Human;Immune response;Impairment;in vivo;Inflammation;Inflammatory;inhibitor;innovation;Interferon Activation;Interferons;IRF4 gene;knock-down;Knowledge;Laboratories;Laboratory Personnel;Lead;lenalidomide;Life;Link;Lymphoid Cell;Malignant - descriptor;Malignant Neoplasms;Mission;Modeling;Molecular;Molecular Target;Multiple Myeloma;Natural regeneration;novel;novel drug combination;Outcome;paracrine;parent project;Pathway interactions;Patients;PF4 Gene;Pharmaceutical Preparations;Pharmacotherapy;Phenotype;plasma cell development;Plasma Cell Neoplasm;Plasma Cells;Play;Pre-Clinical Model;prevent;Productivity;progenitor;programs;Proteins;Public Health;Publications;Reagent;Recurrent disease;Refractory;Relapse;Request for Proposals;Research;response;RNA-targeting therapy;Role;Sampling;self-renewal;Signal Transduction;small hairpin RNA;small molecule;standard of care;stem cell genes;stem cell population;stem cells;stem-like cell;stemness;Stromal Cells;success;Survival Rate;synergism;System;targeted treatment;Testing;Therapeutic;Therapeutic Effect;therapeutic evaluation;therapeutic target;transcription factor;Translations;treatment strategy;tumor;United States;United States National Institutes of Health;Wages;Work

PROJECT_TITLE: Core transcriptional regulators of malignant stem cell generation in multiple myeloma

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 2 Study Section[MCT2]


NIH_SPENDING_CATS: Complementary and Integrative Health;Microbiome

ORG_CITY: LOS ANGELES

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE The human gut microbiome is intimately connected with health, with disruptions of its ecological composition associated with numerous diseases. Manipulations of the microbiome via fecal microbiome transplants, in which microbial strains derived from healthy donor stool are introduced to a patient’s gut community, have been found to be effective treatments for some diseases but not all. This project will determine the evolutionary processes relevant for colonization and persistence of invading strains to a microbiome community, and in doing so will make contributions relevant both to the basic science of microbiome evolutionary dynamics as well as clinical treatment of microbiome–associated diseases

PI_NAMEs: GARUD, NANDITA  (contact)

PROGRAM_OFFICER_NAME: KEANE-MYERS, ANDREA

PROJECT_TITLE: Evolutionary Dynamics of the Human Gut Microbiome During Colonization


ADMINISTERING_IC: DK

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Clinical Research;Dissemination and Implementation Research;Nutrition;Prevention;Social Determinants of Health

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: NARRATIVE Stores provide over two-thirds of calories and added sugar in the US diet, and advertising within stores influences consumer decisions. This project will be the first to describe advertising (e.g., branded signage) for foods and beverages stocked in store checkout lanes—an area of stores known to trigger impulse purchases— and will assess the most compelling messages for garnering public support for healthy checkout policies. Results of this project can inform the development of healthy retail policies and programs and can facilitate dissemination of evidence-based policy.

PI_NAMEs: FALBE, JENNIFER  (contact)

PROGRAM_OFFICER_NAME: EVANS, MARY

PROJECT_TERMS: Adopted;Advertising;Advocate;Affect;Area;Authorization documentation;Behavior;Beverages;Calories;Candy;Cities;Code;Consolidated Framework for Implementation Research;Consumption;cost;Country;Dairying;Data;Development;Diet;Dietary Fiber;Disease;Effectiveness;Environment;Ethnic Origin;Evaluation;evidence base;experience;Fabaceae;Food;food environment;Fruit;implementation barriers;implementation determinants;implementation evaluation;improved;Income;Influentials;innovation;Intervention;Interview;Knowledge;Laws;Licensing;Methods;Natural experiment;Neighborhoods;Non-Insulin-Dependent Diabetes Mellitus;novel;Nuts;obesity risk;Outcome;parent grant;Policies;Policy Maker;Population;post implementation;Prevalence;programs;Proxy;Public Health;Race;Reaction;Research;Sales;Sampling;Sodium;soft drink;sugar;Surveys;sweetened beverage;tool;Vegetables

PROJECT_TITLE: Diversity Supplement for: Impact of a Healthy Checkout Policy on Healthfulness of Grocery Environments and Sales

STUDY_SECTION: SSPB

STUDY_SECTION_NAME: Social Sciences and Population Studies B Study Section[SSPB]


NIH_SPENDING_CATS: Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_DEPT: ENGINEERING (ALL TYPES)

PHR: The second phase of NIH Common Fund 4D Nucleome Network Organizational Hub Narrative The second phase of the 4DN program will study chromatin dynamics in live cells, complex tissues, and disease conditions. The 4DN Organizational Hub is proposed to: (1) coordinate and integrate the efforts of all the funded projects, (2) build an efficient consortium infrastructure to serve as a center for the collaborative efforts, and (3) provide the 4DN web portal as a central resource gateway to access all the 4DN-Network generated tools, policies, guidelines, protocols, reagents, and cell lines.

PI_NAMEs: ZHONG, SHENG  (contact)

PROGRAM_OFFICER_NAME: FINGERMAN, IAN M

PROJECT_TERMS: American;Cell Line;Cells;Cellular biology;Chromatin;Communication;Communities;Complex;Data;Decision Making;Disease;Educational workshop;Ensure;Funding;Guidelines;Human Genetics;Infrastructure;meetings;Methods;Organizational Efficiency;organizational structure;outreach;Phase;Policies;Problem Solving;Process;programs;Protocols documentation;Reagent;Reporting;Research;Resources;Schedule;Societies;symposium;synergism;Tissues;tool;United States National Institutes of Health;web portal;wiki;working group


ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Contact PD/PI: Benn, Emma Katherine Tara NARRATIVE The FIRST Cohort Program at the Icahn School of Medicine at Mount Sinai (ISMMS) will integrate development of a Roadmap for Inclusive Excellence strategic plan, a Cohort/cluster model of recruitment of a diverse cohort of early-career faculty committed to diversity and inclusive excellence, and a robust program of faculty development. The program’s goals are to effect sustainable culture change at our institution and to support the FIRST Cohort faculty hires in obtaining extramural funding. Project Narrative Page 283

PI_NAMEs: BENN, EMMA KATHERINE TARA (contact);CAMPBELL, KIRK N;NESTLER, ERIC J.;RICHARDSON, LYNNE D.

PROGRAM_OFFICER_NAME: CALZOLA, JESSICA MARIE

PROJECT_TERMS: Acceleration;Address;Administrative Supplement;Advisory Committees;Award;Biomedical Research;Black race;career;Career Mobility;Climate;climate change;cohort;Collaborations;Committee Members;Communities;Data;Development;Development Plans;diversity and inclusion;early-career faculty;Educational workshop;Ensure;Equity;Extramural Activities;Faculty;faculty support;Financial compensation;Fostering;Funding;gender equity;Goals;Grant;Health equity research;Health system;Individual;Institution;Interview;Investments;Latinx;Leadership;Life;marginalization;medical schools;Medicine;Mentors;Modeling;novel;peer coaching;Policies;primary outcome;Process;Program Evaluation;programs;Protocols documentation;racism;recruit;Research;Secure;Standardization;Strategic Planning;success;Surveys;Teacher Professional Development;Training;Travel;Underrepresented Populations;United States National Institutes of Health;Work

PROJECT_TITLE: Administrative Supplement for NIH FIRST at Mount Sinai to Support FIRST Faculty Travel


ORG_CITY: VIENNA

ORG_NAME: NOUR HEART, INC.

ORG_STATE: VA

PHR: Narrative In this two-year Direct-to-Phase II SBIR project, Nour Heart, Inc. (NHI) will prepare and file an Investigational New Drug (IND) for FDA approval to initiate CCrP Phase I safety trial in human healthy volunteers. Based on the FDA response to NHI’s Pre-IND application (PIND 125867), we will: 1) produce Good Manufacturing Practice grade CCrP and determine its Chemistry Manufacturing and Controls; 2) conduct FDA-recommended, IND- enabling CCrP preclinical safety studies in rats, dogs, and human unused cadaver donors (UCDs) (initial rat studies indicated that CCrP is a safe drug); 3) conduct a pilot in vivo efficacy study in pigs to confirm the ability of CCrP to safely extend cold storage time of pig hearts to 6 hours before surgically transplanting the graft into recipient pigs; and 4) prepare CCrP Phase I safety protocol and assemble and file Nour Heart’s IND application to the FDA for an indication for end-stage heart failure patients scheduled for heart transplantation procedures. Future broader use of CCrP that can safely extend transport time (>4 hours), could significantly reduce the number of unused donor hearts & expand supply of useable human donor hearts, thus, potentially increase heart transplant cases by over 3,000 yearly.

PI_NAMEs: ELGEBALY, SALWA A (contact)

PROGRAM_OFFICER_NAME: SHANBHAG, SUJATA MADHUKAR

PROJECT_TERMS: acute toxicity;Address;Aftercare;aged;Agreement;Animals;Apoptosis;Bioenergetics;Biological Markers;Blood;Blood specimen;Brain Death;Cadaver;Canis familiaris;Capital;Cardiac;cardioprotection;cell injury;Chemistry;Clinical Pathology;Clinical Protocols;commercialization;Cryopreservation;design;Dose;efficacy study;Electrocardiogram;Eligibility Determination;Family suidae;Feasibility Studies;Fibrosis;Food and Drug Administration Drug Approval;Future;Good Manufacturing Process;Grant;Harvest;Health;healthy volunteer;Heart;Heart failure;heart function;heart preservation;Heart Transplantation;Hour;Human;in vivo;Inflammation;Injections;inorganic phosphate;interest;Intravenous infusion procedures;Investigational Drugs;Investigational New Drug Application;Ischemia;ischemic injury;Legal patent;Letters;manufacture;Measures;medication safety;metabolic profile;Myocardial;novel;Operative Surgical Procedures;Organ Donor;Organ Procurements;Orphan Drugs;Pamphlets;Patient Schedules;Patients;Pharmaceutical Preparations;Pharmacologic Substance;Phase;Phase I Clinical Trials;phase I trial;Pilot Projects;preclinical safety;preclinical study;Prevention;Procedures;Protocols documentation;Rattus;Recommendation;Recovery;response;Safety;safety study;Sales;Saline;Sampling;Small Business Innovation Research Grant;System;Testing;Texas;Therapeutic;therapeutic evaluation;Time;Tissues;Toxic effect;transplant model;Transplantation;Transplantation Surgery

PROJECT_TITLE: Nourexal™: A Novel Bioenergetic Drug to Increase Donor Heart Utilization

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IVBH-V (11)]


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

ORG_CITY: ATHENS

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF GEORGIA

ORG_STATE: GA

PHR: Narrative Paraquat (PQ) is a commonly used herbicide that has been linked to increased risk for Parkinson's disease (PD). PQ-induced neurodegeneration is tightly coupled to the activation of microglia and appears to require priming of the microglial response. However, the mechanistic pathways leading to this priming remain to be firmly established. Hv1 (HVCN1) is a voltage-gated proton channel highly expressed on microglia in the brain and in other immune cells in the body. This proton channel regulates the activity of NADPH oxidase and production of reactive oxygen species. This proposal seeks to test the hypothesis that Hv1 regulates priming of microglia following PQ exposure through the NLRP3 inflammasome, leading to neuroinflammation and neurodegeneration. Successful completion of this project will define regulatory mechanisms for Hv1 and determine the role of Hv1 in regulation of the NLRP3 inflammasome activation and their role in PQ-induced neuroinflammation and neurotoxicity. Together, these results will provide crucial information on the function of a novel regulator of neuroinflammation, Hv1, and determine whether targeting Hv1 may be a viable therapeutic strategy in toxicant-induced neurodegeneration.

PI_NAMEs: RICHARDSON, JASON R (contact);WU, LONG-JUN

PROGRAM_OFFICER_NAME: HOLLANDER, JONATHAN

PROJECT_TERMS: Animal Disease Models;Anti-Inflammatory Agents;Autopsy;Behavioral;Brain;brain cell;Cells;chromatin immunoprecipitation;Clinical Trials;conditional knockout;Coupled;Data;dopaminergic neuron;driving force;Electrophysiology (science);Environment;Enzyme-Linked Immunosorbent Assay;Epigenetic Process;experimental study;first responder;genetic approach;genetic inhibitor;Goals;Herbicides;Histone Acetylation;Human;Immune;In Vitro;in vivo;Infection;Inflammasome;Inflammatory;Inflammatory Response;inhibitor;Knock-out;Knockout Mice;Link;Measures;Mediating;Mediator;Microglia;NADPH Oxidase;Nerve Degeneration;Neurodegenerative Disorders;neuroinflammation;neuroprotection;neurotoxicity;novel;Paraquat;Parkinson Disease;patch clamp;Pathway interactions;Patients;Pharmaceutical Preparations;pharmacologic;Production;protein aggregation;Protons;Reactive Oxygen Species;Regulation;Research;response;Risk;Role;Sampling;Signal Pathway;Signal Transduction;Techniques;Testing;Therapeutic;toxicant;transcription factor;voltage

PROJECT_TITLE: Microglial Hv1 Proton Channel as a Mediator of Environmentally-Induced Neuroinflammation and Neurodegeneration

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Prevention;Social Determinants of Health

PHR: NARRATIVE Preexposure prophylaxis (PrEP) is an effective tool to reduce new HIV infections, however, it is underutilized, especially in the South and among heavily impacted groups, such as racial and ethnic minorities. This application focuses on the development and evaluation of a multifaceted strategy to improve PrEP implementation among individuals incarcerated at the Dallas County Jail. By using data from electronic health records and patients’ health histories to identify candidates for PrEP, engaging them in informed decision- making about PrEP, and providing navigation to PrEP care upon community re-entry, this project has potential to improve PrEP use and reduce HIV infections in this vulnerable population.

PI_NAMEs: KRAKOWER, DOUGLAS SCOTT;NIJHAWAN, ANK ELISABETH (contact)

PROGRAM_OFFICER_NAME: POLLARD-BRANCHARD, SUZANNE LEE

PROJECT_TERMS: acquired factor;Affect;AIDS prevention;Back;Black Populations;candidate identification;Caring;Clinical;clinical care;Communities;community reentry;County;Criminal Justice;Decision Making;Development;Diagnosis;effectiveness/implementation study;electronic health data;Electronic Health Record;ethnic minority;Evaluation;evidence base;Exploration, Preparation, Implementation, and Sustainment;Future;Goals;Health;HIV;HIV diagnosis;HIV Infections;HIV/STD;implementation evaluation;implementation outcomes;implementation process;implementation science;implementation strategy;Imprisonment;improved;Incidence;Individual;innovation;Interruption;Jail;Latinx population;Location;Measures;medically underserved;Methods;Modeling;Outcome;patient oriented;Patients;Penetration;Persons;Population;pre-exposure prophylaxis;Prevalence;Prisons;Public Health;Qualitative Research;racial minority;Recording of previous events;Resources;Risk Factors;Rural;Series;shared decision making;System;Testing;Time;tool;trend;United States;virtual;Vulnerable Populations;Work

PROJECT_TITLE: Trends in Incidence and Prevalence of HIV Diagnoses in a Jail Population in the Southern United States

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_DEPT: NEUROSCIENCES

PHR: Project Narrative – From Parent Grant Alzheimer's disease (AD) is a debilitating disorder that causes severe memory impairments, but it remains unclear the specific memory circuits and mechanisms that break down to impair cognition. The medial entorhinal cortex is an early site of pathology and thus may also be an important site of circuit dysfunction that contributes to cognitive deficits. This proposal will characterize how medial entorhinal and hippocampal circuits break down during the progression of memory deficits in three well-validated mouse models of AD pathology.

PI_NAMEs: SHUMAN, TRISTAN  (contact)

PROGRAM_OFFICER_NAME: WAGSTER, MOLLY V

PROJECT_TERMS: abeta accumulation;Affect;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Amyloid beta-Protein;Brain region;cell type;Cells;Clinical Trials;Code;Cognitive deficits;combinatorial;Dementia;Development;Disease;Disease Progression;Electrophysiology (science);entorhinal cortex;Exhibits;experimental study;Functional disorder;Hippocampus;Impaired cognition;In Vitro;in vivo calcium imaging;insight;Medial;Memory;Memory impairment;Memory Loss;Microscope;Modeling;mouse model;Mus;Nerve Degeneration;Neurons;parent grant;Pathologic;Pathology;Pattern;Pharmaceutical Preparations;prevent;Property;Proteins;Running;Silicon;Site;spatial memory;stellate cell;Symptoms;tau Proteins;Testing;Therapeutic Intervention;tool;Transgenes;Viral

PROJECT_TITLE: Entorhinal-hippocampal interactions during progressive memory impairments in mouse models of Alzheimer's disease pathology


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Bioengineering;Brain Disorders;Burden of Illness;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Palliative Care;Patient Safety;Prevention;Telehealth

ORG_CITY: EL DORADO HILLS

ORG_NAME: HIDO TECHNOLOGIES, INC.

PHR: The Phase II SBIR goal is to enhance, validate, & commercialize HiDO-ALZ, an automated, secure, artificial intelligence (AI) driven medication delivery & observation platform to maximize therapy compliance & health outcomes in dementia. Dementia and Alzheimer’s disease (AD) negatively impact medication management, especially when type 2 diabetes mellitus (DM) occurs as a comorbidity. Development of novel AI technology to improve independent patient adherence to complex medication schedules and remote reporting of compliance metrics to caregivers & providers would significantly optimize patient care and reduce healthcare costs.

PI_NAMEs: AGGARWAL, NEELUM T.;GELLMAN, CHARLES  (contact)

PROGRAM_OFFICER_NAME: SALIVE, MARCEL

PROJECT_TERMS: Activities of Daily Living;Adherence;Admission activity;Adult;adverse drug reaction;adverse outcome;age effect;age related;aging in place;Alzheimer's Disease;Artificial Intelligence;Automation;Biometry;Blood Pressure;care costs;Caregiver Burden;Caregivers;Caring;Clinic;Clinical;Clinical Trials;commercialization;comorbidity;Complex;Consumption;cost;dashboard;data dashboard;data integration;Data Sources;Dementia;design;Development;Devices;diabetes management;Diabetes Mellitus;Disparity population;dosage;Dose;Electronic Health Record;Emergency department visit;Engineering;Ensure;experience;Face;Family;field study;Foundations;Goals;Health;Health Care Costs;health care service utilization;Home;hospital readmission;Hospitalization;Impaired cognition;improved;Incidence;Individual;Ingestion;innovation;Intuition;Label;Lead;machine vision;manufacturing process;Marketing;Measurement;medication administration;Medication Errors;Medication Management;medication nonadherence;Modification;Monitor;Morbidity - disease rate;mortality;new technology;Non-Insulin-Dependent Diabetes Mellitus;novel;Nursing Homes;older adult;Older Population;Outcome;Patient Care;Patient Compliance;Patients;Performance;Persons;Pharmaceutical Preparations;Phase;pill;prevent;Procedures;Production;Protocols documentation;Provider;Quality of life;remote sensor;Reporting;Risk Factors;Route;Schedule;Secure;sensor;Serious Adverse Event;Small Business Innovation Research Grant;smartphone application;socioeconomic disparity;Symptoms;System;Technology;technology platform;Testing;therapy adherence;Time;tool;trend;Update;usability;Vascular Dementia;Videoconferencing;Weight

PROJECT_TITLE: Preventing Medication Mismanagement in People Living with Dementia through Automated Medication Dispensing with Facial Recognition and Video Observation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CCHI-J (10)]


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Liver Disease;Organ Transplantation;Orphan Drug;Rare Diseases;Transplantation

ORG_CITY: BOTHELL

ORG_NAME: PHARMAIN CORPORATION

ORG_STATE: WA

PHR: Narrative: Half of patients who develop refractory ascites due to advanced liver cirrhosis will die within a year without a liver transplant. Pharmacological therapies that can extend survival by stabilizing the disease and function as a therapeutic bridge to liver transplantation are desperately needed. PHIN-214 was invented and developed using Phase 2 SBIR funding that allowed the showing of both proof of concept and small scale GMP materials material that is only sufficient for the ongoing but separately funded Phase 1 clinical trial. This proposal is intended to request additional funding to produce sufficient GMP materials along with more chronic animal testing for the upcoming Phase 2 efficacy and pivotal clinical trial. This activity will bridge the clinical material gap between Phase 1 and Phase 2 clinical trial. PharmaIN Corp. Confidential Information

PI_NAMEs: CASTILLO, GERARDO M. (contact)

PROGRAM_OFFICER_NAME: DENSMORE, CHRISTINE L

PROJECT_TERMS: Acute;acute care;Adverse effects;Affect;Agonist;alcohol use disorder;Ambulatory Care;American;Animal Testing;Animals;Ascites;Blood;Bolus Infusion;Canis familiaris;Child;Chronic;Cirrhosis;Clinical;Clinical Data;clinical material;Clinical Research;clinical research site;Clinical Trials;Confidential Information;cost effective;Creation of peritoneovascular shunt;Death Rate;dietary restriction;Disease;Disease Progression;Diuretics;Dose;drug development;effective therapy;Equilibrium;Europe;Exhibits;Face;Fluid overload;Functional disorder;Funding;Furosemide;Glomerular Filtration Rate;Greater sac of peritoneum;Half-Life;Health Care Costs;health care settings;Heart;hemodynamics;Hemorrhage;Hepatic Encephalopathy;Hepatitis C;Hepatorenal Syndrome;Histologic;Hospital Costs;Human;improved;infection risk;Infrastructure;Injections;intrahepatic;intravenous administration;Intravenous Bolus;invention;Ischemia;Liquid substance;Liver Cirrhosis;Liver diseases;liver transplantation;Lysine;manufacture;Marketing;Maximum Tolerated Dose;Medical;Modeling;Monitor;mortality;mortality risk;Necrosis;non-alcoholic fatty liver disease;Operative Surgical Procedures;Outpatients;Paracentesis;Patients;Peptides;Peritoneal Fluid;Peritonitis;Pharmaceutical Preparations;pharmacologic;Pharmacologic Substance;Phase;Phase I Clinical Trials;Phase II Clinical Trials;Portal Hypertension;Portal Pressure;Portal vein structure;Practice Guidelines;pressure;Prevalence;prevent;Procedures;Prodrugs;Quality of life;Rattus;Recommendation;Recurrence;Refractory;Reporting;Safety;Shipping;side effect;Skin;Small Business Innovation Research Grant;Sodium Chloride;Sodium-Restricted Diet;Spironolactone;subcutaneous;success;Surgical Portosystemic Shunt;Survival Rate;Therapeutic;Therapeutic Index;Time;Toxicology;Varicosity;vasoconstriction;Vasopressin Receptor;Vasopressins;Vial device

PROJECT_TITLE: Subcutaneous Drug Development for Portal Hypertension Ascites

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 KUDS-R (10)]


PHR: Project narrative: Chronic cardiac injury results in persistent sympathoexcitation, which predisposes patients to ventricular arrhythmias, a leading cause of death worldwide. The proposed research aims to investigate the structural and functional characterization of an identified population of cardiac sympathetic neurons (neuropeptide Y2 receptor-expressing neurons (NPY2R)) that exert potent sympathetic effects on the heart. In this study, we will investigate NPY2R neurons as a selective target in minimizing excessive sympathetic drive to the heart, presenting a potential therapeutic avenue for chronic cardiac injury.

PI_NAMEs: AJIJOLA, OLUJIMI A (contact)

PROGRAM_OFFICER_NAME: TJURMINA, OLGA A

PROJECT_TERMS: Animal Model;Animals;antagonist;Arrhythmia;Atherosclerosis;Attenuated;Calcium Signaling;Cardiac;Cardiomyopathies;Catecholamines;Cause of Death;Chronic;Communication;Congestive Heart Failure;Connexin 43;cytokine;Data;Development;Dilated Cardiomyopathy;Frequencies;Functional disorder;Funding;G-Protein-Coupled Receptors;Genetic;glial activation;Goals;Grant;Heart;Heart failure;Heart Injuries;Heart Rate;Human;human data;human model;Hypertension;Infarction;Inflammatory;Injury;Ischemia;Link;Mediating;mortality;mouse model;multidisciplinary;neural;Neuroglia;Neuronal Dysfunction;neuronal excitability;Neurons;neuropeptide Y2 receptor;neurotransmission;novel;optogenetics;Patients;Pharmaceutical Preparations;Population;porcine model;prevent;Reperfusion Therapy;Research;Research Personnel;response;Role;Signal Transduction;Structure of stellate ganglion;Sympathetic Ganglia;Sympathetic Nervous System;Synapses;Techniques;Testing;Therapeutic;tool;Up-Regulation;Ventricular;Ventricular Arrhythmia;Ventricular Tachycardia;Withdrawal

PROJECT_TITLE: Understanding Modulation of Neuronal Subpopulations by Sympathetic Glia

STUDY_SECTION: MPPB

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology B Study Section[MPPB]


NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Health Services;Mental Health;Mental Illness;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Post-Traumatic Stress Disorder (PTSD);Prevention;Suicide;Suicide Prevention;Women's Health Research

ORG_CITY: Springfield

ORG_NAME: OREGON RES BEHAVIORAL INTERVENTION STRAT

ORG_STATE: OR

PHR: 8. PROJECT NARRATIVE Pregnancy and early infant loss are common yet there are insufficient therapeutic resources to prevent and address the psychological complications of loss among bereaved parents including posttraumatic stress disorder and suicidality. This Phase II application proposes to expand and assess the efficacy of a promising digital therapeutic called Along With Me which combines cognitive behavioral therapy, mindfulness, informational support, normalization of grief, and healthcare professional training to provided necessary support to bereaved parents. In the present context of limited and delayed access to behavioral health resources, our mobile app will nest a flexible mobile app within healthcare settings to address significant perinatal public health challenges including preventing postpartum deaths by suicide among bereaved parents.

PI_NAMEs: CIOFFI, CAMILLE C;SMITH, DAVID RANDOLPH (contact)

PROGRAM_OFFICER_NAME: HAIM, ADAM J

PROJECT_TERMS: acceptability and feasibility;Acute;Address;Administrator;Adopted;Adoption;American;antenatal;Anxiety;Area;Attenuated;behavioral health;Benchmarking;Bereavement;Birth;Birthing Centers;Black race;Caring;Cause of Death;Cessation of life;Child;Clinic;Clinical Trials;Cognitive;Cognitive Therapy;Collaborations;Communities;cost;Counseling;Country;Coupling;Data;Dedications;Development;digital treatment;Discipline of obstetrics;Disease;Distress;efficacious treatment;efficacy evaluation;Evaluation;evidence base;experience;Family;Feedback;Feeling;Feeling suicidal;flexibility;follow-up;Funding;Goals;Grief reaction;Guilt;health care service organization;health care settings;Health Professional;Health Resources;health training;Healthcare;Hospitals;Impairment;improved;improved outcome;Indigenous;Infant;innovation;Intervention;Language;Licensing;Life;Marketing;medical specialties;Mental Depression;Mental Health;mindfulness;mobile application;Mothers;National Institute of Mental Health;offspring;Online Systems;Outcome;Outcome Measure;Palliative Care;Parents;peer;Perinatal;Perinatal mortality demographics;perinatal period;Persons;Phase;Population;Positioning Attribute;post-traumatic stress;Post-Traumatic Stress Disorders;post-traumatic symptoms;Postpartum Period;Pragmatic clinical trial;Pregnancy;prevent;primary outcome;programs;prototype;Provider;psychologic;psychological distress;Public Health;Random Allocation;randomized trial;Randomized, Controlled Trials;Reproductive Health;Research;Resources;Risk;Rural;Self Efficacy;Services;services as usual;Severities;Spanish;Spanish/English;Spontaneous abortion;stillbirth;suicidal;suicidal morbidity;Suicide;Suicide prevention;Symptoms;systematic review;Testing;Theory of Change;Therapeutic;Thinking;tool;Training;Trauma;traumatic event;traumatic stress;treatment as usual;treatment program;United States;usability;Walking;web app;Woman;World Health

PROJECT_TITLE: Walk with Me (WWM) for Perinatal Grief

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BP-C (10)]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Comparative Effectiveness Research;Health Services;Mental Health;Mental Illness;Patient Safety;Serious Mental Illness;Telehealth

ORG_CITY: DECATUR

ORG_NAME: VIRTUALLY BETTER, INC.

PHR: PROJECT NARRATIVE Hoarding Disorder (HD) is characterized by the acquisition of and failure to discard clutter, impacting millions of Americans, causing significant impairment, and representing a substantial public health, safety, and economic burden. Effective evidence-based treatment exists for HD, however, patient adherence to treatment is a frequent challenge, resulting in limited improvement for many. This Phase I STTR seeks to develop an innovative and interactive patient-provider digital health tool, Clutter-GO™, to facilitate increased support and patient adherence to this life-changing treatment, which has the potential to improve patient outcomes and reduce public health burden.

PI_NAMEs: ADAMS LARSEN, MARGO  (contact);WHEATON, MICHAEL GRADY

PROGRAM_OFFICER_NAME: SWEENEY, MARY MARGARET

PROJECT_TERMS: Accountability;Address;Adherence;Adopted;Adoption;Affect;American;Area;Behavioral;Benchmarking;Caring;Childhood;Climacteric;Clinical;clinical efficacy;Clutterings;Cognitive Therapy;Communities;Compulsive Hoarding;Computer software;Consultations;Coping Skills;Data;design;Development;Diagnosis;digital;digital health;digital technology;digital tool;Disease;Distress;Economic Burden;Elements;Emotional;Emotional Bonds;Ensure;Evidence based treatment;experience;Failure;Feedback;Functional impairment;Goals;handheld mobile device;health care delivery;Health Technology;Home;Image;Impairment;improved;Individual;Industry Standard;innovation;Instruction;interactive multimedia;International;Libraries;Licensing;Measures;Mental Health;Mental Health Services;Methods;mobile application;Modeling;Monitor;National Institute of Mental Health;Online Systems;Outcome;Paper;Patient Compliance;patient response;Patient-Focused Outcomes;Patients;Peripheral;Phase;phase 2 testing;Population;Positive Reinforcements;Practice Guidelines;Prediction of Response to Therapy;primary outcome;product development;prototype;Provider;psychoeducation;Psychological reinforcement;Public Health;Quality of life;Randomized, Controlled Trials;reduce symptoms;Research;Resources;Rewards;Risk;Safety;Sampling;Side;Small Business Technology Transfer Research;Social isolation;Sorting;standard measure;Structure;success;Symptoms;System;Technology;technology development;telehealth;Testing;Text;Therapeutic;Time;timeline;Titrations;tool;treatment adherence;Treatment Effectiveness;Treatment Protocols;Update;usability;Validation;Visual;Writing

PROJECT_TITLE: Clutter-GO: Facilitating Delivery and Adherence in Evidence-Based Treatment for Hoarding Disorder via a Patient-Provider Digital Health Tool


NIH_SPENDING_CATS: Biotechnology;Genetics;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: LEXINGTON

ORG_NAME: UNIVERSITY OF KENTUCKY

PHR: Research in my lab leverages the experimental tractability and remarkable regenerative abilities of planarian flatworms to uncover fundamental molecular mechanisms that link injury-induced signals to functional changes in gene expression. An undergraduate student in my laboratory has generated preliminary data suggesting that contraction of the planarian body wall muscle may be critical for the activation of key regeneration genes, a finding that has broad implications for regenerative medicine. As post-baccalaureate researcher, she will test her hypothesis using multiple orthogonal approaches.

PI_NAMEs: DUNCAN, ELIZABETH MARIE (contact)

PROGRAM_OFFICER_NAME: PHILLIPS, ANDRE W

PROJECT_TERMS: Address;Adult;Animal Model;Animals;Binding;Biochemical;Biological;Biological Process;Biology;career;cell fate specification;cell type;Cells;Chemicals;Chromatin;Cilia;comparative genomics;Competence;Complex;Cues;Data;Development;Developmental Process;Dissociation;DNA;Doctor of Medicine;Doctor of Philosophy;Embryonic Development;Enzymes;Epithelium;Essential Genes;Event;Fellowship;Functional Regeneration;Funding;Future;Gene Activation;Gene Expression;Gene Expression Regulation;Genes;Genetic;Genetic Transcription;Genome;Genomic approach;genomic locus;Genomics;Goals;Grant;Heterogeneity;in vivo;inhibitor;injured;Injury;insight;interest;Knowledge;Laboratories;Laboratory Study;Lead;Link;Measurement;Mediator;Methods;MLL gene;Molecular;Multipotent Stem Cells;Mus;Muscle;Muscle Contraction;Muscle Fibers;Natural regeneration;Neurons;Organism;overexpression;Paper;parent grant;Pattern;Pharmaceutical Preparations;Physiological;Planarians;Platyhelminths;Play;Pluripotent Stem Cells;Population Heterogeneity;Postbaccalaureate;Principal Investigator;Process;programs;Proteins;Proteomics;Publications;Recreation;regenerative;Regenerative capacity;Regenerative Medicine;regenerative tissue;Regulation;replacement tissue;Research;Research Personnel;response;Retina;RNA Interference;Role;Science;Signal Induction;Signal Transduction;Signaling Protein;single cell analysis;Somatic Cell;stem cell population;stem cells;Structure;Talents;Testing;Tissue Differentiation;tissue regeneration;Tissues;tool;trait;transcription factor;Translating;undergraduate student;Width;Work;wound closure

PROJECT_TITLE: The role of muscle contraction in gene activation and tissue regeneration

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(55)-R]


NIH_SPENDING_CATS: Hematology;Infectious Diseases;Sepsis

ORG_CITY: Alachua

ORG_NAME: MEDOSOME BIOTEC, LLC

ORG_STATE: FL

PHR: PROJECT NARRATIVE Sepsis is the leading cause of death and readmissions in US hospitals. Currently the overall level of unmet need is high as there is a near absence of licensed sepsis-specific products. This may be in part because of the complexity of sepsis and lack of a clear target; furthermore the involvement of multiple organs poses a major hindrance. Recently, our understanding of the underlying mechanisms of severe sepsis has broadened, with the appreciation of how pathological perturbations in intermediary metabolism and bioenergetics of innate and adaptive immune cells and organs drive their fate and function and, hence, the host’s response to sepsis. Such metabolic reprogramming provides the impetus for emerging strategies, whereby targeting metabolism can affect the response of both immune cells and vital organ systems Our ultimate goal is to develop the investigational drug dichloroacetate (DCA) as a novel, mechanism-based intravenous therapy for human severe sepsis. DCA represents the first mechanism-based metabolic therapy for severe sepsis.

PI_NAMEs: ALAM, HASAN B (contact)

PROGRAM_OFFICER_NAME: KODURI, SAILAJA

PROJECT_TERMS: Address;Adult;Aerobic;Affect;aggressive therapy;Animal Model;Anti-Inflammatory Agents;Applications Grants;Bioenergetics;Body System;Cachexia;Cause of Death;cecal ligation puncture;Cells;Chemistry;Child;Clinical Research;Clinical Trials;Collaborations;commercialization;Congestive Heart Failure;Consultations;cytokine;Data;Defect;Development;Dichloroacetate;Disease;dosage;Dose;Drug Evaluation;Drug Kinetics;Engineering;Evaluation;experimental study;Failure;Family suidae;Florida;Foundations;Funding;Future;Genes;Glucose;Goals;Grant;GSTZ1 gene;Haplotypes;hemodynamics;hospital readmission;Hospitals;Human;Immune;immune activation;Immune response;improved;Inflammation;inhibitor;International;Intestines;Intravenous;intravenous injection;Investigational Drugs;Investigational New Drug Application;Lactic Acidosis;Leukocytes;Licensing;Life;Liver;Lymphocyte;manufacture;Marketing;Metabolic;Metabolism;Mitochondria;mouse model;Multicenter Trials;multidisciplinary;Myocardial;Myocardial Ischemia;novel;novel strategies;Oral;Organ;oxidation;Oxidative Phosphorylation;Paralysed;Pathologic;Patients;PDH kinase;Performance;Pharmaceutical Preparations;Pharmacodynamics;Phase;Phosphorylation;Play;porcine model;pre-clinical;pre-Investigational New Drug meeting;preclinical study;preservation;prevent;prototype;pulmonary arterial hypertension;Pyruvate Dehydrogenase Complex;Regimen;Research;response;Role;Runaway;Safety;Scientist;Sepsis;septic;Septic Shock;Small Business Technology Transfer Research;sound;symposium;targeted treatment;Testing;Therapeutic;Therapeutic Effect;Toxic effect;Treatment Protocols;United States National Institutes of Health;Universities;Variant

PROJECT_TITLE: Metabolism and Mitochondrial Energetics Therapy for Septic Shock

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 DCAI-D (10)]


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Complementary and Integrative Health;Emerging Infectious Diseases;Infectious Diseases;Natural Products

ORG_CITY: PITTSBURGH

ORG_NAME: CHEMIA BIOSCIENCES, INC.

PHR: Project Narrative / Public Health Relevance. Antibiotic resistance is a major public health problem worldwide, with antibiotic resistant pathogens infecting hundreds of millions and killing over a million patients worldwide each year. Infections such as pneumonia, tuberculosis, blood poisoning, gonorrhoea, and foodborne diseases are becoming harder or impossible to treat with the existing medicine. This project creates a service for high-throughput discovery of saccharide natural products drug leads with activity against ESKAPE pathogens.

PI_NAMEs: BEHSAZ, BAHAR  (contact)

PROGRAM_OFFICER_NAME: CROUCHER, LEAH TOLOSA

PROJECT_TERMS: Amikacin;Aminoglycosides;Anti-Infective Agents;Antibiotic Resistance;Antibiotics;antimicrobial;antimicrobial resistant infection;Benchmarking;Biochemical Reaction;Biological Sciences;chemical reaction;Chemicals;Chemistry;Clinical;Cloud Service;commercial application;Computer Analysis;Data;Data Set;Databases;drug discovery;drug resistant pathogen;Enzymes;ESKAPE pathogens;follow-up;foodborne illness;Fractionation;Gene Cluster;Gene Modified;Genes;Genome;Gentamicins;Genus staphylococcus;global health;glycosyltransferase;Goals;Gonorrhea;High Pressure Liquid Chromatography;Human Cell Line;Infection;Kanamycin;Letters;Licensing;Literature;machine learning method;Mass Spectrum Analysis;Medicine;Methods;Microbe;microbial;microbial genome;Microbial natural product;microbial products;Mining;Modernization;Modification;Molecular;monomer;multiple omics;Natural Extract;Natural product discovery;Natural Product Drug;Natural Products;Neomycin;novel;Ointments;pathogen;Patients;payment;Pharmaceutical Preparations;Phenotype;Pneumonia;polyketides;Polysaccharides;Process;Public Health;public health relevance;Reporting;Research Personnel;Sampling;screening;Septicemia;Services;small molecule;software development;Streptomyces;Streptomycin;Structure;Techniques;Technology;Testing;text searching;Therapeutic;Ticks;Time;Tobramycin;Toxic effect;Tuberculosis;United States Department of Agriculture;Validation;Variant;Vertebral column

PROJECT_TITLE: Scalable discovery of saccharide natural products using high-throughput multi-omics

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MBBC-G (10)]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Social Determinants of Health

ORG_CITY: EUGENE

ORG_NAME: IRIS MEDIA, INC.

PHR: Public Health Narrative  Although the number of lesbian, gay, bisexual, transgender, and queer (LGBTQ+) parents with children has increased dramatically over the last decade, existing parent training programs have neither been empirically tested with LGBTQ+ parents, nor adapted to address the challenges LGBTQ+ parents face. To address this disparity in parenting education, we propose to tailor evidence-based material derived from attachment, family systems, and social interaction learning theories to meet the needs of LGBTQ+ parents. The training is expected to increase the use of effective parenting strategies, reduce parental stress, and improve child outcomes.

PI_NAMEs: GOLDBERG, ABBIE ELIZABETH;PENNEFATHER, JORDAN ;WENDT, ADAM JOHN (contact)

PROGRAM_OFFICER_NAME: PARSAFAR, PARISA

PROJECT_TERMS: Address;Adoption;aged;behavioral health;Child;Child Behavior;Child Rearing;cisgender;Communities;coping;Couples;Development;Disparity;E-learning;Education;effective intervention;efficacy evaluation;Emotional;empowerment;Evaluation;evidence base;experience;Face;Family;family building;Feedback;Female;fitness;Gender;Gender Identity;Goals;Health;Heterosexuals;heuristics;human centered design;improved;information gathering;Instruction;Intervention;Knowledge;Laws;Learning;Legal;Lesbian Gay Bisexual Transgender Queer;Letters;male;Marriage;Marriage and Family;Medical;Mental Health;Modeling;Outcome;Parenting Education;parenting intervention;Parents;Participant;Patient Self-Report;Persons;Phase;Population;Prejudice;programs;promote resilience;Public Health;Randomized, Controlled Trials;Reporting;Research;Research Design;resilience;Resources;Rights;satisfaction;Self Efficacy;Services;Sex Orientation;Sexual and Gender Minorities;skills;social;Social Interaction;social stigma;Stress;stressor;support network;System;Testing;Text Messaging;theories;tool;Training;Training Programs;Treatment Efficacy;usability;Waiting Lists

PROJECT_TITLE: Evidence-based Parent Training for Diverse Families (PTDF)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 SCIL-D (10)]


NIH_SPENDING_CATS: Bioengineering;Breast Cancer;Cancer;Rehabilitation;Telehealth;Women's Health Research;Wound Healing and Care

ORG_CITY: CONROE

ORG_NAME: SAGESPECTRA INC.

PHR: PROJECT NARRATIVE Apart from being an economic burden, flap failures due to vascular occlusions or surgical site infections can becomplex and traumatic for the patients. SageSpectra is developing for the first time a wireless patch system that can record tissue oxygenation, edema and relative temperature that enables post-operative, remote monitoring and treating of the patients for assessing flaphealth and wound healing.

PI_NAMEs: HECK, MADISON  (contact)

PROJECT_TERMS: analog;Animals;Aphorisms;Biological Markers;biomechanical engineering;Blood Vessels;Businesses;Caring;cloud platform;Collection;Computer software;Computers;cost;Data;data exchange;design;Deterioration;Development;Devices;Distal;Drops;Economic Burden;Edema;Effectiveness;efficacy study;Electric Stimulation;Electric Stimulation Therapy;Emergency Care;Ensure;experience;experimental study;Failure;Family suidae;Feasibility Studies;feasibility testing;Graft Rejection;Health;Health Insurance Portability and Accountability Act;Health Personnel;Home;hospital readmission;Hospitals;In Vitro;in vitro testing;in vivo;in vivo evaluation;in vivo Model;Infection;Ischemia;Legal patent;Length of Stay;Mammaplasty;Mastectomy;Measurement;Measures;Medical;medical attention;Medical Care Costs;Medical Device;Methods;Microsurgery;Modeling;Monitor;monitoring device;Necrosis;novel;Obstruction;Operative Surgical Procedures;Patch Tests;Patient Compliance;Patients;Phase;Physicians;Physiologic pulse;Plastic Surgeon;Plastic Surgical Procedures;porcine model;Postoperative Period;pre-clinical;Procedures;Property;prototype;remote monitoring;Research;Running;Saints;sensor;Site;Skin;Small Business Innovation Research Grant;soft tissue;Spectrometry;success;Surface;Surgeon;Surgical Flaps;Surgical Wound Infection;Symptoms;System;Techniques;Technology;Temperature;Testing;Texas;Therapeutic Effect;Time;tissue oxygenation;tissue phantom;tissue reconstruction;Tissue Viability;Tissues;Transplantation;Trauma;Treatment Cost;Universities;Validation;Veterinarians;wireless;Work;wound healing

PROJECT_TITLE: Development and validation of a wireless patch for post-surgical monitoring and electrotherapy of surgical flaps

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 ISB-S (11)]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Immunization;Infectious Diseases;Vaccine Related

ORG_CITY: PHILADELPHIA

ORG_NAME: INTEGRAL MOLECULAR

PHR: PROJECT NARRATIVE This proposal will contribute to public health and the cure of disease by creating a transformative technology for testing the neutralizing capacity of sera and antibodies, increasing laboratory throughput by 10-fold and dramatically expanding the number of laboratories that can safely perform viral neutralization assays. The proposed assays would impact the capabilities and capacity of clinical labs at both full-service CROs and large vaccine developers, as well as pandemic preparedness being coordinated by the NIH, BARDA, and academic laboratories.

PI_NAMEs: DORANZ, BENJAMIN J (contact)

PROGRAM_OFFICER_NAME: PLIMACK, MARY KATHERINE BRADFORD

PROJECT_TERMS: 2019-nCoV;Abbreviations;Antibodies;Authorization documentation;Biological Assay;Catalogs;Cell Culture Techniques;cell preparation;Cells;Classification;Clinical;commercialization;Containment;Cryopreservation;Cryopreserved Cell;Cultured Cells;Development;Disease;Emergency Situation;Enzymes;experience;experimental study;Family;Freezing;Future;future pandemic;Health;Hour;Human Resources;improved;Industry;Infection;Influenza A Virus, H5N1 Subtype;Laboratories;Lassa virus;Luciferases;Measurement;Measures;Molecular;National Institute of Allergy and Infectious Disease;Neutralization Tests;North America;novel;occupational health/safety;Optical reporter;Optics;pandemic disease;pandemic potential;pandemic preparedness;pandemic response;pandemic virus;pathogen;pathogenic virus;Procedures;Production;Proteins;prototype;Public Health;public health emergency;Publishing;Quarantine;Readiness;Reagent;Recovery;Reporter;Reporting;Research Personnel;response;Risk;Sampling;Serum;Services;Signal Transduction;System;Technology;Testing;Time;timeline;United States National Institutes of Health;Vaccination;Vaccine Clinical Trial;Vaccinee;Vaccines;Variant;Vesicular stomatitis Indiana virus;Viral;Virion;Virus;Virus Diseases;Work

PROJECT_TITLE: Development of Safe and Rapid Reporter Viruses for Studying Pathogenic and Pandemic Viruses

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 DCAI-B (13)]


ORG_CITY: ATLANTA

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: EMORY UNIVERSITY

PHR: Project Narrative The proposed work seeks to elucidate the structural and mechanistic basis for the regulation of RNA-dependent innate immune antiviral proteins that control translation to curb viral infection. Completion of the proposed research will not only produce critical fundamental insights into the arms race of host-virus, but will also inform the design of novel therapeutic strategies against rapidly evolving viruses and many chronic diseases, both of which pose severe and costly threats to public health.

PI_NAMEs: BOU-NADER, CHARLES  (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Adenoviruses;Alternative Splicing;Anti-Inflammatory Agents;Architecture;arms race;Autoimmune Diseases;Award;Base Pairing;Binding;Biochemical;Biological Assay;Biological Products;biophysical analysis;biophysical techniques;Calorimetry;career development;Cellular Stress;Chalk;Chronic Disease;Complex;Consultations;cost;crosslink;Cryoelectron Microscopy;Crystallography;design;Development Plans;Devices;Disease;Double-Stranded RNA;Educational process of instructing;Elements;Endoribonucleases;Evaluation;Extramural Activities;Fluorescence Polarization;Foundations;Funding;Future;Genetic Transcription;Genetic Variation;HIV-1;Human;Human poliovirus;Immune;Immune response;immunogenicity;In Vitro;Infection;infectious disease treatment;Inflammatory;inhibitor;Innate Immune Response;inorganic phosphate;insight;Institution;Integration Host Factors;Interferons;International;Interview;Intramural Research;Knowledge;Leadership;Lentivirus;Link;Maps;Mass Spectrum Analysis;Measures;Mediating;Mentors;Messenger RNA;Molecular;Molecular Conformation;Mutagenesis;National Institute of Diabetes and Digestive and Kidney Diseases;Natural Immunity;novel;novel therapeutic intervention;novel therapeutics;nuclease;Nucleic Acids;Occupations;oligoadenylate;Pathway interactions;Phase;phosphodiester;Phosphotransferases;Positioning Attribute;Postbaccalaureate;Predisposition;Principal Investigator;PRKR gene;Protein Binding Domain;Protein Biochemistry;protein expression;protein function;Protein Inhibition;Protein Isoforms;protein kinase R;protein protein interaction;Proteins;Public Health;reconstitution;Regulation;Research;research and development;Research Personnel;Resistance;Ribonucleases;Risk Factors;RNA;RNA Decay;RNA Recognition Motif;RNA Splicing;Scientist;Secure;single-molecule FRET;Site;skill acquisition;skills;Solid;Stress;structural biology;Structure;tenure track;Testing;tool;Training;Transcript;translation factor;Translation Initiation;Translational Repression;Translations;tripolyphosphate;United States National Institutes of Health;Untranslated RNA;Vertebral column;Viral;Viral Genome;Viral Physiology;Viral Proteins;viral RNA;Virus;Virus Diseases;Virus Inhibitors;Virus Replication;Vocational Guidance;Work;X-Ray Crystallography

PROJECT_TITLE: Mechanisms of Nucleic Acid Immunogenicity

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Asthma;Lung

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

PHR: Project Narrative Mast Cell Expressed Membrane Protein 1 (MCEMP1) is one of the top inducible genes in the lung of asthma patients, yet a pathological role of MCEMP1 is entirely unknown. I will address a role of MCEMP1 in KIT-mediated mast cell proliferation and asthma development, ultimately identifying a new therapeutic strategy for treating asthma.

PI_NAMEs: CHOI, YOUN JUNG  (contact)

PROGRAM_OFFICER_NAME: LU, JINING

PROJECT_TERMS: Accounting;Address;Adoptive Transfer;airway hyperresponsiveness;Allergens;Allergic;Allergic Disease;Allergic Reaction;Anaphylaxis;Antigens;Asthma;asthma exacerbation;asthma model;asthmatic patient;Attenuated;Award;bronchial epithelium;Bypass;Cell Count;Cell Physiology;Cell Proliferation;Cells;Chimeric Proteins;Complex;cytokine;Cytoplasm;Dendritic Cells;Development;Extrinsic asthma;Functional disorder;Genes;idiopathic pulmonary fibrosis;IgE;Immunization;In Vitro;in vivo;Inflammatory;inflammatory lung disease;inhibitor;Injections;insight;Integral Membrane Protein;Intranasal Administration;ITAM;Libraries;Ligands;Llama;Lung;Lung Diseases;Macrophage;mast cell;Mediating;Membrane Proteins;migration;Molecular;monocyte;mouse model;Mus;Mutagenesis;nanobodies;new therapeutic target;novel;novel therapeutic intervention;novel therapeutics;Ovalbumin;Pathogenesis;Pathologic;Pathway interactions;Patients;Peritoneal;Phase;Phosphorylation;Phosphotransferases;Play;Production;Proliferating;Pulmonary Inflammation;Pyroglyphidae;receptor;Receptor Signaling;Recovery;recruit;Regulation;Role;Severities;Severity of illness;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Stem Cell Factor;stem cells;Stimulus;Surface;System;Techniques;Testing;Therapeutic;therapeutic development;Wild Type Mouse;Yeasts

PROJECT_TITLE: MCEMP1 is an adaptor for KIT receptor for mast cell proliferation


NIH_SPENDING_CATS: Lung;Organ Transplantation;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

ORG_CITY: COLUMBUS

ORG_NAME: RESEARCH INST NATIONWIDE CHILDREN'S HOSP

PHR: Project Narrative: Lung transplantation is often the best remaining treatment option for patients with end-stage lung disease, but immune rejection can limit long-term survival. We must address major knowledge gaps in how airway cells are renewed in lungs after transplantation and how the recipient's immune system targets and destroys airway stem cells. Thus, there is a critical need to develop and use appropriate animal models to study the destruction of stem cells in the lung.

PI_NAMEs: LYNCH, THOMAS J (contact)

PROGRAM_OFFICER_NAME: KALANTARI, ROYA

PROJECT_TERMS: activation-induced cytidine deaminase;Address;Adopted;airway epithelium;airway regeneration;Allografting;Animal Model;Antigens;Autoantigens;Autoimmune;Autoimmune Responses;Autoimmunity;B-Lymphocytes;Bypass;Cause of Death;Cell Compartmentation;Cell Lineage;Cell surface;Cells;Chronic;Data;Development;Disease;Disease Progression;Distal;Duct (organ) structure;Ductal Epithelial Cell;Ectopic Expression;Epithelial Cells;epithelial stem cell;epithelium regeneration;experience;Ferrets;Fibrosis;Foundations;Functional disorder;Gland;Goals;Health;Human;Immune;Immune mediated destruction;Immune response;Immune system;Immune Targeting;Impairment;improved;in vitro Assay;in vivo;injured airway;Injury;innovation;insight;K-Series Research Career Programs;Knowledge;Left;Lung;lung allograft;Lung Diseases;Lung Transplantation;Lymphoid Follicle;Modeling;Morbidity - disease rate;Multipotent Stem Cells;Myoepithelial cell;Natural regeneration;novel;Pathology;Pathway interactions;Patients;Pattern;Phase;Phenotype;Physiology;pressure;prevent;Process;progenitor;Property;Proteins;Publishing;pulmonary function;pulmonary function decline;Reaction;reconstitution;regeneration function;regenerative;Regenerative Medicine;Research;Reserve Stem Cell;resilience;response;Rodent Model;Role;severe injury;Signal Transduction;single cell ATAC-seq;single-cell RNA sequencing;stem cell exhaustion;stem cell niche;stem cell self renewal;stem cell therapy;stem cells;Stress;Submucosa;Surface;Testing;Transgenic Organisms;transplant model;Transplantation;Work

PROJECT_TITLE: Lung Allograft Stem Cell Regeneration and Immune Destruction


NIH_SPENDING_CATS: Aging;Nutrition;Prevention

ORG_CITY: BLACKSBURG

ORG_DEPT: NUTRITION

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

PHR: NARRATIVE The goal of this application is to dissect out the unique functions of Perilipin5 and its role in healthspan and longevity-inducing interventions. This work is a significant as Perilipin5 has been shown to mitigate metabolic disease but its ability to influence health or lifespan has yet to be established. By focusing on a novel niche in lipid signaling and directly relating Perilipin5 to health and lifespan, we are establishing strong fundamental biology that is extremely relevant to healthy aging and healthspan promoting interventions.

PI_NAMEs: NAJT, CHARLES P (contact)

PROGRAM_OFFICER_NAME: CARTER, CHRISTY

PROJECT_TERMS: Ablation;Adipose tissue;age acceleration;age related;Aging;aging process;aging related;Area;Autophagocytosis;Binding;Biogenesis;Biology;Biotin;Caloric Restriction;Catabolism;Cell Nucleus;Cell Physiology;Cell Respiration;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Couples;Cyclic AMP;Cyclic AMP-Dependent Protein Kinases;Cytoplasm;Data;Deacetylase;detection of nutrient;Development;Diet;dietary;Dietary Factors;Dietary Intervention;Environmental Risk Factor;epidemiology study;Fasting;Fatty acid glycerol esters;Fatty Acids;flexibility;FRAP1 gene;Funding;Goals;good diet;Health;Health Benefit;healthspan;healthy aging;improved;Inflammation;interest;Intermittent fasting;Intervention;Intervention Studies;Knock-out;Knowledge;Life;life span;Ligase;Link;Lipase;lipid metabolism;lipid transport;Lipids;Lipolysis;Literature;Longevity;Maps;Mediating;Mediterranean Diet;Metabolic;Metabolic Diseases;Metabolic dysfunction;middle age;Mitochondria;model organism;Monounsaturated Fatty Acids;Morbidity - disease rate;Mus;novel;Nuclear;Nutrient;Olive oil preparation;overexpression;Pathway interactions;perilipin;Physiological;Post-Translational Protein Processing;protective effect;Proteins;Publishing;Research;Research Personnel;response;Role;sensor;Signal Transduction;SIRT1 gene;Sirtuins;Supplementation;Surface;synergism;Testing;Time;Tissues;Triglycerides;Work

PROJECT_TITLE: Perilipin 5: Linking lipid droplets to nutrient sensing and healthy aging


NIH_SPENDING_CATS: Attention Deficit Hyperactivity Disorder (ADHD);Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Pediatric

ORG_NAME: NURELM E-BUSINESS SOFTWARE

PHR: Project Narrative ADHD is the most common behavioral diagnosis in early childhood affecting around 9% of US children. Although hyperactivity is a core symptom of ADHD, there are no objective measures that are widely used in clinical trial settings that can measure response to treatment. This SBIR project will refine and validate a software system for smartwatches to measure hyperactivity with objectivity and precision in context using state-of-the-art sensors and machine learning algorithms.

PI_NAMEs: GOEL, MAYANK ;KENNEDY, TRACI M.;SHAABAN, SAMI  (contact)

PROGRAM_OFFICER_NAME: GRABB, MARGARET CHRISTINE

PROJECT_TERMS: acceptability and feasibility;actigraphy;Address;Affect;Age;Algorithms;Assessment tool;Attention deficit hyperactivity disorder;Automation;Behavior assessment;Behavioral;behavioral health;Child;Classification;Clinical;Clinical Investigator;Clinical Trials;Collection;commercialization;commercialization readiness;Computer software;Data;Data Collection;data management;design;Diagnosis;Disease;early childhood;efficacy evaluation;efficacy testing;Environment;Family;feature extraction;Feedback;Future;Health Insurance Portability and Accountability Act;Holidays;Hyperactivity;improved;innovation;Innovation Corps;insight;Interview;Life;Machine Learning;machine learning algorithm;machine learning model;Manuals;Manuscripts;Marketing;Measurement;Measures;Modeling;Modernization;Motion;Movement;National Institute of Mental Health;Outcome Assessment;Outcome Measure;Outcome Study;Parents;Participant;Peer Review;Pharmaceutical Preparations;Pharmacologic Substance;Phase;Positioning Attribute;process improvement;programs;prototype;Publications;Publishing;Questionnaires;Research;Research Personnel;response;Risk;Schools;Scientist;Sensitivity and Specificity;sensor;sensor technology;Severities;Small Business Innovation Research Grant;smart watch;software systems;Standardization;Stimulant;Strategic Planning;success;Symptoms;System;Systems Integration;teacher;Technology;Testing;Time;Titrations;tool;transmission process;Treatment Efficacy;Treatment outcome;treatment response;Universities;Update;usability;user-friendly;validation studies;Visual;wearable data;wearable device;Work

PROJECT_TITLE: Using Machine Learning and Sensing to Contextualize Hyperactivity Measurement on Wearable Devices


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;HIV/AIDS;Infectious Diseases;Mental Health;Neurosciences;Pediatric;Pediatric - AIDS;Prevention;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: There are millions of adolescents and young adults (AYA) living with perinatally acquired HIV (PHIV) facing the challenge of increased responsibility and adult roles requiring greater demands on their neurocognition; yet, they experience greater rates of neurocognitive impairment (NCI) and worse health and functional outcomes than their uninfected peers. This study will delineate how lifelong HIV infection acquired prior to key physiological, immunological and brain development, as well as timing, duration and type of ART, may alter immune system responses that affect how NCI manifests in adolescence and young adulthood, as well as how exposure to chronic adversity may affect the relationship between immune dysfunction and NCI in HIV-infection. The study will also cohere a group of early and established Ugandan and US investigators focused on optimizing AYA outcomes and provide research opportunities and mentorship to medical, psychiatry and psychology students at Makerere University for collaborative development of next-generation US and Ugandan trainees in brain and immunological health across the lifespan.

PI_NAMEs: DIRAJLAL-FARGO, SAHERA ;MUSIIME, VICTOR ;ROBBINS, REUBEN N (contact)

PROGRAM_OFFICER_NAME: LEE, SONIA S

PROJECT_TERMS: 2019-nCoV;Accounting;Address;Adolescence;Adolescent and Young Adult;Adult;Affect;Africa South of the Sahara;Age;Air Pollution;Behavioral;Brain;brain health;CCL2 gene;CD4 Lymphocyte Count;Child;Chronic;Cognitive;contextual factors;Country;Data;Development;Early-life trauma;Educational workshop;experience;Exposure to;Faculty;FarGo;functional outcomes;Genetic;Health;HIV;HIV Infections;HIV-associated neurocognitive disorder;IL8 gene;immune activation;immune health;Immune response;Immune System Diseases;Immune Targeting;Immunologics;Income;Individual;Inflammation;International;Internships;Intervention;Knowledge;lectures;life span;Machine Learning;Malaria;Measures;Medical;member;Mental Health;Mentors;Mentorship;Neighborhoods;Nervous System Disorder;Neurocognition;Neurocognitive;Neurocognitive Deficit;next generation;novel;Outcome;peer;Perinatal;peripheral blood;Persons;Phenotype;Physiological;Population;Poverty;Psychiatry;Psychology;psychosocial;recruit;Research;Research Personnel;response;Role;social;social stigma;Source;Students;symposium;syndemic;therapy development;Time;TNF gene;Training Support;Uganda;Universities;Viral;young adult

PROJECT_TITLE: Enhancing Novel Research for Inflammation and Cognitive Health among Adolescents and Young Adults Living with Perinatally Acquired HIV and Adversity (ENRICH+)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CN-L (55)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences

ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Project Narrative The protein kinase PKA protects against dementia in Alzheimer’s disease and during aging, and drugs that activate PKA are in clinical development for the treatment of dementia. This proposal provides supplement support for D. Walter Saide, an individual from a Sexual and Gender Minority group, to investigate the ability of PKA to form liquid-like droplets in cells in order to gain a better understanding of PKA’s protective function in the brain.

PI_NAMEs: STRACK, STEFAN  (contact);TAYLOR, SUSAN S.

PROGRAM_OFFICER_NAME: BARRETT, PAUL JOHN

PROJECT_TERMS: Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Brain;Cells;clinical development;Cyclic AMP-Dependent Protein Kinases;Dementia;gender minority group;Individual;Liquid substance;Parents;Pharmaceutical Preparations;Physical condensation;Protein Kinase;protein kinase A kinase;Research;sexual minority group;tau Proteins;therapy development

PROJECT_TITLE: DEI supplement for Interplay between tau and PKA condensates in ADRD