ORG_CITY: NEW ORLEANS

ORG_NAME: SOUTHEAST LOUISIANA VETERANS HEALTH CARE

ORG_STATE: LA

PHR: Project Narrative Approximately 65% of Veterans report pain in the last 3 months, and >50% of Veterans receiving care at VHA facilities report chronic pain. Opioid drugs are the first-line treatment for chronic pain but have many side effects. Here, we hypothesize that brain melanocortin-4 receptors (MC4Rs) are a promising novel non-opioid target for reducing nociception in individuals living with chronic inflammatory pain. More specifically, we will test the predictions that chronic inflammatory pain produces age-specific and sex-specific changes in nociception and pain avoidance. We predict that inflammatory pain will differentially alter MC4R expression & engage descending pain modulation circuits in adolescent and adult male and female rats. We will also test the predictions that MC4R antagonism and descending pain circuit stimulation rescue inflammatory pain effects and that intra-nasal drug delivery holds promise for translation into humans living with chronic pain.

PI_NAMEs: GILPIN, NICHOLAS WARREN (contact)

PROJECT_TERMS: Acute;Adolescence;Adolescent;Adult;Affect;Age;age related;age related changes;aging population;Agonist;Alcohol withdrawal syndrome;American;Amygdaloid structure;Analgesics;Animals;antagonist;ART protein;Arthritis;Biochemistry;Brain;Caring;Chronic;Chronic inflammatory pain;chronic pain;chronic pain management;Chronic pain syndrome;conditioned place preference;cost;Development;disability;Dose;Drug Delivery Systems;Electrophysiology (science);experimental study;Feeds;Female;foot;Freund's Adjuvant;Health;Human;Hyperalgesia;Hypersensitivity;Individual;Inflammatory;inflammatory pain;Infusion procedures;Injections;Intraventricular Injections;Joints;Ligands;Locomotion;male;Male Adolescents;Mechanics;Mediating;Mediator;Melanocortin 4 Receptor;midbrain central gray substance;Military Personnel;Modeling;Morphine;Musculoskeletal;Neurobiology;Nociception;non-opioid analgesic;novel;Opioid;opioid mortality;opioid use disorder;opioid user;optogenetics;Pain;pain patient;pain reduction;Pathway interactions;Pharmaceutical Preparations;prescription opioid;prescription opioid abuse;Prevalence;Rattus;receptor expression;Receptor Signaling;Recreation;Reporting;Rodent;Services;sex;side effect;Slice;Techniques;Testing;Thermal Hyperalgesias;Translations;Veterans;Withdrawal;Work;α-Melanocyte stimulating hormone

PROJECT_TITLE: Targeting melanocortin-4 receptors to reduce pain in U.S. Veterans


ADMINISTERING_IC: CA

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Cervical Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunotherapy;Orphan Drug;Ovarian Cancer;Prevention;Rare Diseases;Uterine Cancer;Vaginal Cancer;Women's Health Research

ORG_CITY: BOSTON

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: DANA-FARBER CANCER INST

ORG_STATE: MA

PHR: Project Narrative Not Applicable.

PI_NAMEs: MATULONIS, URSULA ANNE (contact)

PROJECT_TERMS: Academy;Advanced Development;Age disparity;anti-cancer research;anti-PD-1;Area;Award;Biological Models;biomarker discovery;CA-125 Antigen;Cancer Center;Cancer Center Support Grant;cancer prevention;cancer risk;cancer surgery;cancer therapy;Cancer Vaccines;career;career development;Caring;Catchment Area;Cervical;Clinical;Clinical Trials;Collaborations;combinatorial;Combined Vaccines;community engagement process;Correlative Study;Dana-Farber Cancer Institute;Department of Defense;Development;Diagnostic Procedure;diagnostic technologies;Direct Costs;Disease;Disparity in diagnosis;Early Diagnosis;Endometrial;Endometrial Carcinoma;Environment;Faculty;Fellowship Program;Funding;Germ Cell Cancers;Germ cell tumor;Goals;Grant;Gynecologic;Histology;Human;Immunotherapy;improved;Incidence;Infrastructure;Institution;inter-institutional;Investigation;investigator-initiated trial;K-Series Research Career Programs;Laparotomy;Leadership;Link;Malignant Female Reproductive System Neoplasm;Malignant neoplasm of cervix uteri;Malignant neoplasm of ovary;Malignant neoplasm of vulva;Malignant Neoplasms;Malignant Vaginal Neoplasm;Massachusetts;member;Mentored Clinical Scientist Development Program;Mentors;minimally invasive;Mirza;Mission;Mucinous;Mutate;Mutation;next generation;novel strategies;novel therapeutic intervention;oncology program;Operative Surgical Procedures;Organoids;Outcome;Ovarian;Paper;Patient-Focused Outcomes;Peer Review Grants;Pharmaceutical Preparations;Poly(ADP-ribose) Polymerase Inhibitor;pre-clinical;Pregnancy;Prevention;prognostic method;programs;Publishing;racial disparity;radical hysterectomy;Ras/Raf;Recommendation;Research;Research Personnel;Research Training;Resistance;resistance mechanism;Resource Sharing;response;restoration;Science;Scientist;screening;Screening for cancer;Skates;Strategic Planning;Structure;Suggestion;Surgeon;surgical disparities;Surgical Management;System;Teacher Professional Development;Techniques;Testing;Training;Translational Research;translational scientist;Translations;trend;Tumor Immunity;Vagina;Vulva;Woman;working group

PROJECT_TITLE: Program 02: Gynecologic Cancers

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Genetics

ORG_CITY: Nashville

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: PROJECT NARRATIVE Environmental causes of cancer include chemicals and radiation, as well metabolites that are produced in response to environmental chemicals. These agents induce DNA damage that can be particularly detrimental during DNA replication and requires unique DNA repair processes to overcome. This project will investigate activation and functioning of these specialized DNA repair processes to understand how they mitigate environmental sources of DNA damage.

PI_NAMEs: DEWAR, JAMES M (contact)

PROGRAM_OFFICER_NAME: SHAUGHNESSY, DANIEL

PROJECT_TERMS: Address;Aromatic Polycyclic Hydrocarbons;Back;Behavior;Biochemical;BRCA1 gene;BRCA2 gene;Cancer Etiology;Cell Death;Cells;Chemicals;Complex;Cytoprotection;Data;Defect;Disease;disease-causing mutation;DNA;DNA biosynthesis;DNA Damage;DNA lesion;DNA Repair;DNA Repair Enzymes;DNA replication fork;egg;Ensure;Environment;environmental agent;environmental chemical;Event;Exposure to;Genome Stability;Genomic Instability;helicase;Human;human disease;improved;In Vitro;Individual;Inherited;insight;Ionizing radiation;Learning;Lesion;Malignant Neoplasms;Modeling;Molecular;Mutagens;Mutation;novel strategies;nuclease;Pathway interactions;Predisposition;Process;protein function;Proteins;Radiation;Reactive Oxygen Species;response;Sensitivity and Specificity;single molecule;Site;Source;Specificity;System;Time;Ultraviolet Rays;Vertebrates;Work;Xenopus

PROJECT_TITLE: Mechanisms of replication fork degradation in vertebrates

STUDY_SECTION: MG

STUDY_SECTION_NAME: Molecular Genetics Study Section[MG]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Lung;Orphan Drug;Rare Diseases;Tuberculosis

ORG_CITY: GAINESVILLE

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Project Narrative: This Proposal will delineate a pathway to evaluate combinations of agents (3-4 drugs) for therapy of Mycobacterium tuberculosis. This pathway will identify regimens which will kill rapidly, suppress resistance and allow shortening of duration of therapy.

PI_NAMEs: DRUSANO, GEORGE LOUIS (contact);LOUIE, ARNOLD

PROGRAM_OFFICER_NAME: BOYCE, JIM P

PROJECT_TERMS: Address;Algorithms;Amino Acyl-tRNA Synthetases;Animals;Antimicrobial Effect;Bacteria;base;beta-Lactams;Binding;Biological Assay;C3HeB/FeJ Mouse;Carbapenems;Catabolism;cell killing;Cell Wall;Cells;Cholesterol;Code;cohort;Combination Drug Therapy;Combined Modality Therapy;Complex;Data;data modeling;dosage;Drug Combinations;drug distribution;Drug Exposure;efficacy study;Equation;Evaluation;Excision;Experimental Designs;experimental study;Fiber;flasks;Foundations;High-dimensional Modeling;Human;Image;In Vitro;in vivo;Inbred BALB C Mice;Infection;inhibitor;insight;Kinetics;laser capture microdissection;Lesion;leucine-tRNA;Link;liquid chromatography mass spectroscopy;man;mass spectrometric imaging;mathematical methods;mathematical model;Measures;Metabolic;Modeling;Monobactams;mouse model;Mus;Mycobacterium tuberculosis;New Agents;nonhuman primate;novel;Oral;Organism;Pathologic;Pathology;Pathway interactions;Patients;Penetration;Pharmaceutical Preparations;Phase;Poison;Population;Predisposition;Primary Infection;Property;prospective;Publishing;receptor binding;Regimen;Resistance;response;Rest;Site;Spatial Distribution;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;Speed;Sterilization;Structure of parenchyma of lung;success;supercomputer;Testing;therapy duration;Time;Tissues;Tuberculosis;tuberculosis treatment;Validation;Work;Writing

PROJECT_TITLE: Optimizing Multi-drug Mycobacterium tuberculosis Therapy for Rapid Sterilization and Resistance Suppression

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DDR-C(01)]


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Social Determinants of Health

PHR: Project Narrative Not applicable.

PI_NAMEs: VISWANATH, KASISOMAYAJULA  (contact)

PROJECT_TERMS: Address;Administrator;Advisory Committees;anti-cancer research;Area;barrier to care;Burn injury;Cancer Burden;cancer care;Cancer Center;cancer health disparity;cancer risk;cancer site;cancer therapy;Catchment Area;Charge;Clinical Cancer Center;Clinical Research;Clinical Trials;Communication;Communities;community center;community engaged research;community engagement;community organizations;Community Outreach;community partners;County;design;Disease;Disparity;Education;Ensure;Equity;Ethics;Ethnic Origin;Fostering;Foundations;Gender;Geographic Locations;Goals;Health Services Accessibility;Human Papillomavirus;improved;Individual;Inequity;innovation;Institution;Intervention;life span;liver cancer prevention;Malignant Neoplasms;Massachusetts;Measurement;Minority;minority communities;Minority Enrollment;Minority Participation;Modeling;Monitor;NCI Center for Cancer Research;outreach;programs;Race;Recommendation;Research;research data dissemination;Research Personnel;Resources;response;Risk Assessment;Risk Factors;Screening for Prostate Cancer;Socioeconomic Factors;Strategic Planning;Structure;success;System;Tobacco;Translations;underserved community;Update;Vaccination;vaping;Work;Youth

PROJECT_TITLE: Community Outreach and Engagement


NIH_SPENDING_CATS: Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

PI_NAMEs: HOWLEY, PETER M (contact)

PROJECT_TERMS: Acceleration;Address;anti-cancer research;Area;Award;Basic Science;Cancer Center;cancer clinical trial;cancer health disparity;Catchment Area;Clinical Research;Collaborations;Creativeness;Crystallization;Dana-Farber Cancer Institute;Development;Discipline;Disease;Eligibility Determination;experience;Faith;Funding;Grant;Incentives;Incubators;inter-institutional;interdisciplinary collaboration;interest;Investigation;Joints;Measures;member;Minority;minority patient;Nodal;Peer Review;Pilot Projects;Population Sciences;Process;programs;Reporting;Request for Proposals;Research Personnel;response;Strategic Planning;Strategic vision;Structure;success;Sum;Talents;Time;Training;Translations;Underrepresented Minority;underserved community

PROJECT_TITLE: Developmental Funds


NIH_SPENDING_CATS: Cancer

PI_NAMEs: RITZ, JEROME  (contact)

PROJECT_TERMS: Advanced Malignant Neoplasm;Affect;anti-cancer research;Cancer Center;Cancer Center Support Grant;Charge;Collaborations;cost;Dana-Farber Cancer Institute;Discipline;Disparate;Education;Ensure;Funding;Goals;Institution;Laboratories;member;minority communities;Mission;programs;Research;Research Personnel;Research Support;Resource Sharing;Scientist;Services;Source;Technology;underserved community;Work

PROJECT_TITLE: Shared Resource Management


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

ORG_CITY: WINSTON-SALEM

ORG_DEPT: BIOLOGY

ORG_NAME: WAKE FOREST UNIVERSITY

ORG_STATE: NC

PHR: PUBLIC HEALTH RELEVANCE STATEMENT (NARRATIVE):      Rotaviruses are important causes of life- threatening diarrhea in the young. This proposal will help us understand  how  a  key  enzyme  of  rotavirus  functions  during  infection,  which  could  inform  antiviral  drug  design.  Thus,  the  proposed  research  is  relevant  to  the part  of  NIH's  mission  that  pertains  to  creating knowledge  that will  help to  reduce the burden of human disease.

PI_NAMEs: KELLY, DEBORAH F;MCDONALD ESSTMAN, SARAH MARIE (contact)

PROGRAM_OFFICER_NAME: ALARCON, RODOLFO M

PROJECT_TERMS: 2019-nCoV;3-Dimensional;Anti-viral Agents;Armadillo Repeat;Binding;Biochemical;Biological Assay;Biological Models;Cells;Child;Complex;Cryoelectron Microscopy;Data;Defect;Diarrhea;Disease;Double Stranded RNA Virus;Double-Stranded RNA;Drug Design;Ebola virus;Economic Burden;Engineering;Enzymes;Family;flexibility;Foundations;Genetic Techniques;Genetic Transcription;Genome;Genomic Segment;human disease;human pathogen;Ice;Image;In Situ;In Vitro;in vitro activity;Infection;Influenza A virus;insight;Knowledge;Lesion;Life;Liquid substance;Mammalian Cell;Maps;Medical;Microfluidics;Mission;Molecular Conformation;mutant;N-terminal;particle;Pathogenesis;Performance;Plasmids;prevent;Proteins;public health relevance;Publishing;rational design;Recombinants;reconstruction;Regulation;Reoviridae;replicase;Research;Resolution;reverse genetics;RNA;RNA chemical synthesis;RNA Viruses;RNA-Directed RNA Polymerase;Rotavirus;scaffold;Site;Societies;structural biology;Structure;System;Techniques;Testing;three dimensional structure;Transcriptase;United States National Institutes of Health;Viral;viral RNA;Virion;Virus;Virus Replication;Virus-like particle;Work

PROJECT_TITLE: Rotavirus Genome Replication and Virion Assembly

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIA-B(02)]


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunotherapy;Prevention

PI_NAMEs: SHIVDASANI, RAMESH A (contact)

PROJECT_TERMS: Address;Advanced Malignant Neoplasm;Advisory Committees;Agreement;anti-cancer research;Articulation;Behavioral;Bioinformatics;Biological;Cancer Burden;cancer care;Cancer Center;cancer clinical trial;Cancer Etiology;cancer immunotherapy;cancer prevention;cancer risk;Catchment Area;Clinical;Clinical Sciences;Clinical Trials;combat;Communities;Comprehensive Cancer Center;Dana-Farber Cancer Institute;Development;Diagnosis;Discipline;Disparity;Early Diagnosis;Education;empowerment;Environment;Equity;Ethics;Evaluation;Funding;Future;Genetic;Genetic Heterogeneity;Goals;Grant;Grooming;immune checkpoint blockade;immune-related adverse events;improved;Inequity;innovation;Institution;interdisciplinary approach;Interdisciplinary Study;Investigation;Laboratories;Leadership;Malignant Neoplasms;member;minority patient;Mission;new technology;next generation;novel strategies;Oncogenic;outreach;Pathway interactions;Play;Population Sciences;Prevention;Preventive;Process;programs;Race;Research;Research Personnel;Resource Sharing;Resources;Risk Assessment;Risk Reduction;Role;single cell technology;socioeconomics;Strategic Planning;Strategic vision;symposium;synergism;Talents;therapy resistant;Training;Training and Education;Treatment outcome

PROJECT_TITLE: Leadership, Planning, and Evaluation


NIH_SPENDING_CATS: Cancer;Networking and Information Technology R&D (NITRD);Patient Safety

PI_NAMEs: MEYERHARDT, JEFFREY A (contact)

PROJECT_TERMS: Address;Cancer Biology;cancer care;Cancer Center;cancer immunotherapy;clinical center;Clinical Data;Clinical Protocols;Clinical Research;Clinical Trials;Comprehensive Cancer Center;Computerized Medical Record;Data;data management;data quality;Dedications;Dependence;disparity reduction;Education;Enrollment;Ensure;functional improvement;Grant;improved;Individual;Industry;Inequity;Informatics;Information Systems;Information Technology;Infrastructure;Institution;inter-institutional;interdisciplinary approach;Intervention Trial;Iris;Manuals;member;Monitor;new technology;operation;Operations Research;Participant;Patients;Procedures;Process;process improvement;Protocols documentation;quality assurance;Quality Control;Reporting;Research;Research Personnel;Resources;Services;Site;Strategic vision;Structure;System;timeline;treatment trial

PROJECT_TITLE: Clinical Protocol and Data Management


ADMINISTERING_IC: NR

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Pediatric;Social Determinants of Health

ORG_CITY: ANN ARBOR

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE The consequences of the COVID-19 pandemic have been unequally felt by individuals and communities across the United States. To understand these patterns, we will create, integrate, and share data on neighborhood characteristics, both before and since the pandemic, that can be readily linked to existing survey or cohort studies at various levels of geography. This national neighborhood data resource will support the scientific community in understanding the mechanisms that may convey risk and resilience, particularly in underserved and vulnerable populations, and will allow us to more effectively prepare for the next public health emergency.

PI_NAMEs: CLARKE, PHILIPPA  (contact);NOPPERT, GRACE A

PROGRAM_OFFICER_NAME: GODETTE, DIONNE

PROJECT_TERMS: Address;Adolescent;Age;American;archive data;Area;Barbering;Behavioral;behavioral outcome;Businesses;Caring;Censuses;Characteristics;Child;Clinical Research;Cohort Studies;Common Data Element;Communities;County;COVID-19;COVID-19 impact;COVID-19 outbreak;COVID-19 pandemic;COVID-19 pandemic effects;Data;data archive;data infrastructure;data resource;data sharing;density;disease transmission;driving force;economic impact;economic indicator;Economic Models;economic outcome;Economics;Education;Educational workshop;Electronic Health Record;Employment;Environment;Environmental Hazards;ethnic minority;Ethnic Origin;experience;flexibility;Funding;Geography;Growth;Health;health care availability;health economics;health inequalities;Health Personnel;Health Promotion;Individual;Infrastructure;innovation;Internet;Letters;Libraries;Link;Locales;Loneliness;Maps;Measures;Medical;Mental Health;Nail plate;Neighborhoods;Occupations;older adult;pandemic disease;Pattern;Pharmacy facility;Physical activity;Policies;Politics;Population;post-pandemic;psychological outcomes;public health emergency;Race;racial minority;Racial Segregation;Recording of previous events;Research;Research Priority;resilience;Resources;response;Risk;Role;rural area;school environment;Schools;Shapes;skills;social;Social Distance;Social Interaction;Social isolation;Social outcome;socioeconomic disadvantage;socioeconomics;Source;Standardization;Structure;substance use;Surveys;Telemedicine;tool;trend;Underserved Population;United States;Universities;Update;Visualization;volunteer;Vulnerable Populations;walkability;Work

PROJECT_TITLE: A National Neighborhood Data Resource to Understand Inequities in the Health and Socioeconomic Impacts of COVID-19 in the United States


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

PROJECT_TERMS: cancer care;Cancer Center;cancer immunotherapy;cancer therapy;Catchment Area;Clinical;Clinical Research;Clinical Research Protocols;Clinical Trials;Collection;Committee Membership;Dana-Farber Cancer Institute;Data;Disease;disparity reduction;Ensure;Epidemiology;Ethics;feasibility trial;Goals;Grant;improved;Inequity;innovation;Institution;Institutional Review Boards;interdisciplinary approach;Intervention;Iris;Knowledge;life span;Malignant Neoplasms;member;Monitor;new technology;Notification;operation;Participant;Patients;Phase;Policies;Procedures;Process;programs;Protocols documentation;Research;Research Personnel;Review Committee;Route;Science;Site;standard of care;Strategic vision;System;Time;Underrepresented Minority

PROJECT_TITLE: Protocol Review and Monitoring System


ADMINISTERING_IC: MH

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Social Determinants of Health

ORG_CITY: STORRS-MANSFIELD

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF CONNECTICUT STORRS

ORG_STATE: CT

PHR: Stigma impedes every step along the HIV continuum of care, including uptake and adherence to antiretroviral therapy (ART). While intersectional stigma has become the focus of much research in high-income countries, far less is known about how intersectional stigma impacts the HIV continuum of care in low-income countries. This pre-doctoral training and research project leverages an existing research infrastructure to test a novel measure of intersectional stigma in relation to HIV treatment adherence among men and women living with HIV in South Africa.

PI_NAMEs: EL-KRAB, RENEE  (contact)

PROGRAM_OFFICER_NAME: KAMATH, SUSANNAH M A

PROJECT_TERMS: Address;Adherence;Africa South of the Sahara;AIDS prevention;alcohol and other drug;antiretroviral therapy;Behavior Therapy;Black race;Caring;Clinic;Clinical;Continuity of Patient Care;Country;Data;Dimensions;doctoral student;Drug usage;Environment;Epidemic;experience;Failure;falls;Feedback;Fellowship;forging;Funding;Gender;Health;Heterosexuals;high risk men;HIV;HIV Infections;HIV Seropositivity;HIV therapy;Homophobia;improved;Income;Individual;insight;interest;International;intersectionality;Intervention;Interview;Joints;knowledgebase;low income country;Measurement;Measures;men;Mentors;National Institute of Mental Health;novel;novel strategies;Outcome;Participant;Patients;Performance;Persons;Phase;Population;Poverty;pre-doctoral;Prevalence;Prospective Studies;Psychometrics;recruit;Reporting;Research;Research Infrastructure;Research Personnel;Research Project Grants;Resources;response;Sampling;Sex Orientation;Sexism;sexual minority men;social;social health determinants;social stigma;sound;South Africa;South African;Stigmatization;Testing;therapy adherence;Time;Traction;training project;transmission process;treatment adherence;Treatment Failure;treatment research;United States;United States National Institutes of Health;uptake;Validity and Reliability;Viral;Woman;Women's study

PROJECT_TITLE: A Novel Intersectional HIV Stigma Measure in South Africa


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Immunization;Immunotherapy;Nanotechnology;Orphan Drug;Pancreatic Cancer;Precision Medicine;Rare Diseases

ORG_CITY: DAVIS

ORG_DEPT: NUTRITION

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

ORG_STATE: CA

PHR: Narrative Pancreatic cancer is one of the most deadly malignancies in the United States. In this highly collaborative study, a multidisciplinary team of investigators from the University of California at Davis, TargaGenix and Northeastern University, will collaborate to develop a clinically translatable nanoemulsion-based delivery system for our lead agent in combination with immunotherapy for effective treatment of pancreatic tumors. The proposed solution will lead to the development of a promising new combination anticancer therapeutic modality, especially against aggressive and highly metastatic diseases, such as pancreatic cancer.

PI_NAMEs: AMIJI, MANSOOR M.;EGAN, JAMES E;KIM, EDWARD J;MACKENZIE, GERARDO GUILLERMO (contact)

PROGRAM_OFFICER_NAME: OLKHANUD, PUREVDORJ BALJINNYAM

PROJECT_TERMS: 3-Dimensional;Abraxane;Acids;advanced pancreatic cancer;Affect;Animal Model;anti-cancer therapeutic;anti-PD-L1;anti-PD-L1 antibodies;anti-PD-L1 therapy;Antibody Therapy;Biodistribution;California;cancer immunotherapy;Canis familiaris;CD8-Positive T-Lymphocytes;checkpoint inhibition;chemotherapy;Clinical;clinical development;Clinical Research;clinical translation;Clinical Treatment;Clinical Trials;clinically relevant;Collaborations;Combined Modality Therapy;cytotoxicity;Data;Dedications;density;Development;Diagnosis;Disease;Docosahexaenoic Acids;Dose;Drug Combinations;Drug Kinetics;effective therapy;efficacy evaluation;Evaluation;experience;Fibrosis;Formulation;Foundations;Future;gemcitabine;Genetically Engineered Mouse;Goals;Growth;Human;immune cell infiltrate;immune checkpoint;immune checkpoint blockade;Immune checkpoint inhibitor;immunogenic;Immunotherapy;improved;improved outcome;In Vitro;in vivo;Industry;industry partner;innovation;interest;KPC model;Lead;lead candidate;Link;Malignant neoplasm of pancreas;Malignant Neoplasms;Mission;Modality;Modeling;multidisciplinary;multimodality;nanoemulsion;nanomedicine;Nanotechnology;next generation;novel;novel therapeutic intervention;novel therapeutics;Oils;Organoids;Paclitaxel;Pancreas Transplantation;pancreatic cancer model;pancreatic cancer patients;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma model;pancreatic neoplasm;Patients;personalized medicine;Pharmaceutical Preparations;Phase I Clinical Trials;Polyunsaturated Fatty Acids;Pre-Clinical Model;Qualifying;rational design;Rattus;Refractory;Research Personnel;Safety;Scientist;Stromal Neoplasm;System;T cell infiltration;Taxoids;Testing;Therapeutic;Therapeutic Agents;Therapeutic Effect;Time;Toxic effect;Toxicology;translatable strategy;Treatment Efficacy;Treatment outcome;treatment strategy;tumor;tumor growth;United States;Universities;Unresectable;Water

PROJECT_TITLE: TGX-1214 - Combination Strategy for the Treatment of Advanced Pancreatic Cancer


ADMINISTERING_IC: NS

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Neurosciences;Sleep Research

ORG_CITY: BALTIMORE

ORG_DEPT: NEUROSCIENCES

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative Sleep amount is highest during early stages of life, and sleep disturbances during this period can have adverse consequences, including increased risk of cognitive disorders later in life. The proposed research will investigate the function of sleep in a genetically identified simple circuit in young animals. This work will contribute to the understanding of the function of sleep in young animals and may help identify novel therapeutic targets for neurodevelopmental disorders.

PI_NAMEs: KELES, MEHMET  (contact)

PROGRAM_OFFICER_NAME: HE, JANET

PROJECT_TERMS: Address;Adult;adverse outcome;Algorithms;Animals;Astrocytes;Attention Deficit Disorder;Attentional deficit;autism spectrum disorder;Behavior;Behavioral;Behavioral Assay;behavioral habituation;behavioral phenotyping;Biological Assay;Body part;Brain;Carbon Dioxide;career;career development;Categories;cell type;Cells;Chronic;Cognition Disorders;Computer Models;Computer software;Coupled;critical period;Data;Data Set;Development;Drosophila genus;early childhood;Electrophysiology (science);Environment;Exhibits;experience;experimental study;Exposure to;Faculty;fly;Foundations;Gene Expression Profiling;Genes;Genetic;Goals;Human;Image;imaging modality;in vivo;Inhibitory Synapse;Interneurons;juvenile animal;knock-down;late life;Life;Lobe;Machine Learning;Manuals;markov model;Mediating;member;Mentors;Methods;model organism;Molecular;Morphology;Muscle;neural;neural circuit;neurobehavioral disorder;neurocognitive disorder;Neurodevelopmental Disorder;Neuronal Plasticity;Neurons;neurophysiology;new therapeutic target;novel;Olfactory Pathways;optogenetics;patch clamp;Physiological;Play;Positioning Attribute;postsynaptic neurons;presynaptic neurons;prevent;Process;programs;Research;research and development;Resources;Risk;RNA interference screen;Role;Scientist;Shapes;Signal Transduction;single-cell RNA sequencing;Sleep;Sleep Deprivation;Sleep disturbances;Sleep Stages;social deficits;Statistical Methods;Statistical Models;Synapses;System;tenure track;Testing;Training;Universities;Work

PROJECT_TITLE: The Function of Sleep in Critical Period Plasticity

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-2 Study Section [NST-2]


ADMINISTERING_IC: EB

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Coronaviruses;Coronaviruses Diagnostics and Prognostics;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Hematology;Immunotherapy;Infectious Diseases;Nanotechnology;Prevention;Sepsis

ORG_DEPT: ENGINEERING (ALL TYPES)

PHR: Project Narrative The proposed research is relevant to public health because it addresses an unmet bioanalytical need in the management of unstable sepsis patients experiencing uncontrolled inflammatory responses. The development of this technology will enable physicians to better define pathophysiologic subtypes within individuals for more precise and effective patient management. Thus, the proposed research is relevant to NIBIB’s mission of integrating engineering sciences with life sciences for the advancement of medical care.

PI_NAMEs: PAN, JING  (contact)

PROGRAM_OFFICER_NAME: MULVANEY, SHAWN PATRICK

PROJECT_TERMS: absorption;Address;Adopted;Affinity;Antibodies;aptamer;Architecture;Binding;Biochemical;Biological Assay;Biological Markers;Biological Models;Biological Sciences;biomarker panel;Biomedical Engineering;Biosensor;Blood;Blood Cells;care costs;Caring;Cessation of life;Chronic;Chronic Disease;Clinical;clinical decision-making;clinical predictors;Clinical Research;Cohort Studies;conflict resolution;COVID-19 patient;COVID-19 treatment;Critical Care;Critical Illness;cytokine release syndrome;Data;Databases;design;Detection;detection limit;Development;Devices;Diagnosis;Diagnostic;diagnostic value;Disease;Disease Management;Disease Progression;Dissociation;Drug Kinetics;Early identification;Engineering;Enzyme-Linked Immunosorbent Assay;Epidemiology;Equilibrium;Event;evidence base;experience;Fluorescence;Future;Goals;Healthcare;Healthcare Systems;Heating;high risk;Hospitals;Hour;Human;Immune;Immune response;Immune System Diseases;Immunoassay;Immunologics;Immunomodulators;Immunophenotyping;immunoregulation;Immunotherapy;improved;In Vitro;Incubated;Individual;individual patient;Inflammatory Response;innovation;Inpatients;Interleukin-6;Intervention;Knowledge;Libraries;Measurement;Medical;Microfluidic Microchips;Mission;Molecular;Monitor;Morbidity - disease rate;mortality;multiplex detection;nanoparticle;National Institute of Biomedical Imaging and Bioengineering;novel;novel therapeutics;Oligonucleotides;operation;Outcome;Patient Care;Patients;Performance;Phenotype;Physicians;plasmonics;predictive tools;Procedures;Process;programmed cell death ligand 1;Property;Proteins;Public Health;rate of change;Reagent;real time monitoring;Recycling;Research;response;response to injury;Sampling;scaffold;Scaffolding Protein;Scheme;Science;Scientist;sensor;Sepsis;septic patients;Septic Shock;severe COVID-19;Signal Transduction;Surface;Survivors;Technology;technology development;Temperature;Therapeutic;Thrombin;Thrombomodulin;Time;tissue injury;Transducers;treatment response;United States;Whole Blood;Work;Yeasts

PROJECT_TITLE: Affinity Reagents and Sensor Platform Development for Blood Biochemical Monitoring

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-U(80)]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: BRONX

ORG_NAME: JAMES J PETERS VA  MEDICAL CENTER

ORG_STATE: NY

PHR: Project Narrative  The COVID-19 pandemic is afflicting millions of individuals worldwide. Our proposed study will compare the specific properties and activities of virus-specific antibodies that are generated in saliva and blood after natural infection versus after vaccination. Findings from this study will provide information that could lead to the development of more effective COVID-19 diagnostics and interventions.

PI_NAMEs: HIOE, CATARINA E (contact)

PROJECT_TERMS: 2019-nCoV;Address;Advanced Development;Affect;Affinity;Animals;Antibodies;Antibody Response;antibody-dependent cellular phagocytosis;Antigens;Binding;Biology;Blood;Body Fluids;Caring;Cells;Cessation of life;China;Chitra;Communicable Diseases;Complement;Complement 1q;convalescent plasma;COVID-19;COVID-19 diagnostic;COVID-19 intervention;COVID-19 pandemic;COVID-19 patient;COVID-19 therapeutics;COVID-19 vaccine;cytokine;cytotoxicity;Data;Death Records;Deposition;Detection;Development;Diagnostic;Disease;Disease Outbreaks;Disease Outcome;DNA Vaccines;Elderly;Employee;experience;Failure;FDA Emergency Use Authorization;Glycoproteins;glycosylation;Goals;high risk population;HIV envelope protein;Hospitalization;Hospitals;Human;IgG1;Immunoglobulin A;Immunoglobulin G;Immunoglobulin Isotypes;Immunoglobulin M;Immunology;improved;Individual;Infection;Inflammatory;Macaca mulatta;male;Mass Spectrum Analysis;Measures;Mediating;Medical center;medical schools;mucosal site;Mucous Membrane;Myeloid Cells;neutralizing antibody;neutrophil;novel coronavirus;pandemic disease;Patients;Phagocytosis;Plasma;Polysaccharides;Population;Positioning Attribute;preclinical study;Predisposition;Production;Property;prophylactic;Proxy;Publishing;receptor binding;Reporting;Research;response;Risk Factors;RNA vaccine;Role;Saliva;saliva sample;SARS-CoV-2 antibody;SARS-CoV-2 infection;SARS-CoV-2 spike protein;severe COVID-19;Signal Transduction;Specialist;Specimen;Structure;Symptoms;Testing;Time;Vaccination;Vaccinee;Vaccines;vector;Veterans;Viral;Virion;Virus;Vulnerable Populations;Work

PROJECT_TITLE: COVID-19: Significance of Fc properties and functions in antibody responses against SARS-CoV-2


ORG_CITY: INDIANAPOLIS

ORG_NAME: RLR VA MEDICAL CENTER

ORG_STATE: IN

PHR: T-cell acute lymphoblastic leukemia (T-ALL) affects both children and adults. T-ALL shows a male predominance and is found in adult patients aged 20-60. This epidemiologic pattern closely fits the demographic of young Veterans. Although T-ALL is an uncommon cancer among Veterans, it has aggressive clinical features that make it difficult to treat. This grant proposes to study adult T-ALL from the perspective of the LMO2 oncogene, which is universally expressed in ETP-ALL and immature T-ALL, both are poor prognosis subtypes that are present in adult T-ALL patients. The specific aims of this grant address the unmet need of therapeutics for ETP and adult T-ALL through novel cutting-edge approaches. Since the LMO2 oncogene may very well be involved in other leukemias that affect Veterans, the findings from the proposed studies have the potential to be applied to multiple other cancers.

PI_NAMEs: DAVE, UTPAL P (contact)

PROJECT_TERMS: Acute T Cell Leukemia;Address;Adult;Adult Precursor T Lymphoblastic Leukemia;Adult T-Cell Leukemia/Lymphoma;Affect;aged;Apoptosis;BHLH Protein;Binding;Binding Proteins;Biochemical;Biological Models;Caring;Cells;chemotherapy;Child;Clinical;Complex;Cytotoxic Chemotherapy;Data;Diagnosis;Disease remission;drug candidate;Epidemiology;Functional disorder;GATA1 gene;Grant;Growth;Hematopoietic stem cells;high risk;Human;human model;Immunoblot Analysis;Immunophenotyping;JAK1 gene;Knowledge;Learning;Lentivirus Vector;leukemia;leukemia initiating cell;leukemia/lymphoma;LIM Domain;LMO2 gene;LYL1 gene;Macromolecular Complexes;male;Malignant Neoplasms;military veteran;Modeling;mouse model;mutant;novel;Oncogenes;Oncogenic;Pathway interactions;Patients;Pattern;Population;Prognosis;Proliferating;Property;Protein Binding Domain;Proteins;Proteomics;Relapse;relapse patients;relapse risk;Remission Induction;Resistance;response;Role;selective expression;small molecule;stem cells;stemness;Structure;T-Lymphocyte;TAL1 gene;targeted treatment;Technology;Testing;Therapeutic;therapy resistant;transcriptome sequencing;transcriptomics;Translating;Veterans

PROJECT_TITLE: Pathophysiology of Adult T-cell leukemia/lymphoma


ORG_CITY: RICHMOND

ORG_NAME: VA VETERANS ADMINISTRATION HOSPITAL

ORG_STATE: VA

PHR: Cancer is the second leading cause of death among US veterans, and lung cancer is associated with the greatest mortality in these patients. Non-small cell lung cancers (NSCLC) represent the majority of lung cancers and carry a poor prognosis with a median survival of less than 12 months. Most patients present with unresectable disease, and current treatment options of chemotherapy and radiation are palliative at best. Our laboratory has identified key mechanisms specific to a particular mutation/ inactivation of tumor suppressor genes in NSCLCs, which are plausible and highly desired targets for the development of new and targeted anti-cancer therapeutics (precision medicine). This grant application explores these cellular mechanisms in depth with the goal of developing new therapeutics to combat NSCLC, and thereby, aid US Veterans.

PI_NAMEs: CHALFANT, CHARLES E. (contact)

PROJECT_TERMS: 19p13;Accounting;Address;Affinity Chromatography;Anchorage-Independent Growth;anti-cancer therapeutic;Anti-sense RNA;Applications Grants;Automobile Driving;Back;Binding;Biological;Cancer cell line;Cancer Etiology;carcinogenesis;Cause of Death;CDK4 gene;CDKN2A gene;Cell Survival;Cessation of life;Chemotherapy and/or radiation;Chromosomes;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;combat;Consensus Sequence;Coupled;CRISPR/Cas technology;Cyclin-Dependent Kinase Inhibitor 2A;Cytoplasm;Data;Developed Countries;Development;Disease;Down-Regulation;Elements;Exclusion;Exons;experimental study;Foundations;Fractionation;gene product;Gene Silencing;Germ Cells;Goals;Human;Investigation;Laboratories;Link;lung cancer cell;Maintenance;Malignant neoplasm of lung;Malignant Neoplasms;men;Messenger RNA;Modification;Molecular;mortality;Mutagenesis;Mutate;Mutation;new therapeutic target;Non-Small-Cell Lung Carcinoma;novel;novel therapeutic intervention;novel therapeutics;Nuclear;Oligonucleotides;palliative;Pathway interactions;Patients;PD-1/PD-L1;Phenotype;precision medicine;Production;Prognosis;Proteomics;Proto-Oncogene Proteins c-akt;Regulatory Pathway;RNA;RNA Splicing;Role;Signal Pathway;Signal Transduction;Site;Site-Directed Mutagenesis;small hairpin RNA;Small Interfering RNA;small molecule inhibitor;Survival Rate;synergism;targeted treatment;Techniques;Technology;Testing;therapeutic RNA;Transcript;transcriptomics;tumor;Tumor Suppressor Proteins;Tumor-Suppressor Gene Inactivation;tumorigenesis;tumorigenic;Tumorigenicity;United States;Unresectable;Untranslated RNA;Validation;Variant;Veterans;Woman

PROJECT_TITLE: The role of RNA splicing in non-small cell lung cancer


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Biodefense and Related Countermeasures;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Influenza;Pneumonia and Influenza;Prevention;Social Determinants of Health

ORG_CITY: PHILADELPHIA

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: DREXEL UNIVERSITY

ORG_STATE: PA

PHR: PROJECT NARRATIVE COVID-19 and influenza account for a substantial disease burden in the United States, and both show substantial disparities. The proposed research uses descriptive, non-experimental, and agent based-modeling to examine 1) neighborhood social determinants of COVID-19 and influenza acute care utilization (hospitalizations and Emergency Department visits) under varying contexts, 2) effects of two policies (paid sick leave and rent control) on these outcomes, and 3) develops hypothesis about the mechanisms linking two key social determinants, occupational exposures and housing overcrowding, and influenza disparities. Findings will advance our understanding of the social and policy drivers of infectious disease disparities and inform policies and interventions that can mitigate disparities in seasonal, endemic, and other potential future respiratory illness pandemics.

PI_NAMEs: SCHNAKE-MAHL, ALINA  (contact)

PROGRAM_OFFICER_NAME: BOZICK, BROOKE ALLISON

PROJECT_TERMS: acute care;Address;Affect;Area;Award;behavior change;burden of illness;career;career development;career networking;Chronic Disease;Cities;City Government;Collection;Communicable Diseases;Complex;COVID-19;COVID-19 burden;COVID-19 disparity;COVID-19 impact;Crowding;Data;Decision Making;design;Disease;disease disparity;Disease Outcome;Disparity;disparity reduction;dynamic system;Emergency department visit;Epidemiologist;Epidemiology;Evaluation;evidence base;experience;Exposure to;flu;Funding;Future;geographic disparity;Goals;Grant;Health Care Research;health equity;health inequalities;Health Policy;Healthcare;Heterogeneity;Home;Hospitalization;Household;Housing;improved;Inequity;Infectious Disease Epidemiology;Influenza;innovation;insight;interdisciplinary approach;Intervention;Knowledge;knowledge base;Laws;Link;Measures;Mentored Research Scientist Development Award;Mentorship;Methods;metropolitan;Minority Groups;Modeling;models and simulation;mortality;multilevel analysis;Neighborhoods;novel;Occupational Exposure;Outcome;outcome disparities;pandemic disease;Persons;Phase;Policies;Policy Analysis;Population;Positioning Attribute;Poverty;preempt;prevent;Public Health;Publications;Race;racial disparity;Research;Research Personnel;Resources;respiratory;Respiratory Disease;Risk;Risk Factors;Science;Seasons;Sick Leave;skills;social;social determinants;social epidemiology;social factors;social health determinants;Social Policies;Social Processes;sociodemographics;socioeconomics;State Government;Structure;surveillance data;System;Techniques;Time;tool;Training;transmission process;United States;United States National Institutes of Health;Vaccination;Variant;Work;Workplace

PROJECT_TITLE: Social and policy determinants and impacts on COVID-19 and influenza disparities

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases B Research Study Section[MID-B]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Biotechnology;Duchenne/ Becker Muscular Dystrophy;Gene Therapy;Genetics;Muscular Dystrophy;Pediatric;Rare Diseases

ORG_DEPT: PEDIATRICS

PHR: PROJECT NARRATIVE:  The overall goal of this proposal is to develop novel vectors with which gene therapy of muscular dystrophies can be achieved with improved safety and efficacy. These vectors are derived from a virus that causes no known disease in humans, and therefore, are expected to be safer. Thus, the development of such a vector system for the potential treatment and cure of these debilitating human diseases has relevance to public health.

PI_NAMEs: DUAN, DONGSHENG ;SRIVASTAVA, ARUN  (contact)

PROGRAM_OFFICER_NAME: CARIFI, EMILY FORAN

PROJECT_TERMS: Address;adeno-associated viral vector;Animal Model;Biological Sciences;Capsid;Capsid Proteins;Cells;Cessation of life;Child;clinical efficacy;Clinical Trials;cost;delivery vehicle;Dependovirus;Development;Disease;DNA-Directed RNA Polymerase;Dose;Duchenne muscular dystrophy;economic cost;Enhancers;Family;gene therapy;gene therapy clinical trial;Gene Transduction Agent;Generations;Genes;Genetic Enhancer Element;Genetic Transcription;Genome;Goals;Human;human disease;Immune response;Immune system;immunogenic;improved;In Vitro;in vivo;in vivo Model;Inverted Terminal Repeat;Limb-Girdle Muscular Dystrophies;Liver;Mediating;micro-dystrophin;mouse model;Muscle;Muscle Cells;Muscle Fibers;muscle form;Muscular Dystrophies;Myoblasts;Myopathy;next generation;novel;novel strategies;Parvovirus;Patients;Pharmaceutical Preparations;Phase;phase II trial;pre-clinical;Probability;Production;Proteins;Public Health;Recombinant adeno-associated virus (rAAV);Recombinants;Regulatory Element;Research;Safety;Serious Adverse Event;Serotyping;Single-Stranded DNA;Skeletal Muscle;Solid;System;Testing;Therapeutic;therapeutic gene;transcription factor;transduction efficiency;transgene expression;United States Food and Drug Administration;vector;vector genome;Virus

PROJECT_TITLE: Development of optimized AAVrh74 vectors for gene therapy of muscular dystrophies

STUDY_SECTION: TAG

STUDY_SECTION_NAME: Therapeutic Approaches to Genetic Diseases Study Section[TAG]


NIH_SPENDING_CATS: Aging;Breast Cancer;Cancer;Estrogen;Menopause;Nutrition;Obesity;Prevention;Women's Health Research

PHR: NARRATIVE  The incidence of obesity-associated breast cancers continues to rise, suggesting that current recommendations to maintaining a healthy body weight and increasing physical activity are not sufficient to decrease this risk at the population level. This proposal will determine if preventing accumulation of fat in abdominal regions could be a specific way to decrease the risk of obesity-related breast cancers during menopause. Results of these studies will have implications for all women with overweight/obesity entering menopause, who are at increased risk for postmenopausal breast cancer.

PI_NAMEs: GILES, ERIN  (contact)

PROGRAM_OFFICER_NAME: PERLOFF, MARJORIE

PROJECT_TERMS: Abdomen;Acceleration;adipokines;adiponectin;Adipose tissue;Biological;Body Composition;Body fat;Body Weight;Body Weight decreased;Breast;Breast Cancer Risk Factor;cancer risk;Chronic;Clinical Data;clinically relevant;Coculture Techniques;cytokine;Data;Deposition;Development;diet and exercise;Distant;Estrogens;Fatty acid glycerol esters;Future;Goals;Grant;Growth and Development function;Growth Factor;Hip region structure;Hormone Receptor;Hormones;In Vitro;in vitro Assay;in vivo;Incidence;individualized prevention;Infiltration;Inflammation;Inflammatory;innovation;Insulin Resistance;Intervention;Knowledge;Life;Link;Lipectomy;Macrophage;Macrophage Activation;Malignant Breast Neoplasm;Malignant Neoplasms;mammary;Mammary Neoplasms;Measurable;Mediating;Menopause;Metabolic;Metabolic Activation;Modeling;mortality;Nature;Nonesterified Fatty Acids;novel;Obesity;Obesity associated cancer;obesity risk;Operative Surgical Procedures;Ovarian hormone;Ovariectomy;Overweight;Perimenopause;Peripheral;pharmacologic;Physical activity;Play;Populations at Risk;Postmenopause;pre-clinical;precision medicine;Premenopause;prevent;Prevention strategy;Process;Production;Publishing;Rattus;Recommendation;Research;Risk;risk minimization;Rodent Model;Role;Sampling;Signal Pathway;Signal Transduction;Site;subcutaneous;Testing;Therapeutic;Time;Tissue Expansion;Tissues;transplant model;tumor;tumor growth;tumor microenvironment;tumor progression;Tumor Promotion;Tumor Subtype;tumorigenic;Visceral;Visceral fat;Weight Gain;Woman

PROJECT_TITLE: Obesity, body fat distribution, and breast cancer risk: is visceral fat the culprit after menopause?

STUDY_SECTION: CPSS

STUDY_SECTION_NAME: Cancer Prevention Study Section[CPSS]


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Patient Safety;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative Home healthcare (HHC) is an important source of care for older Americans with multiple chronic conditions, including those historically at risk for health disparities. Our prior work indicates that infection prevention and control (IPC) in the HHC setting is sub-optimal and HHC agencies were not prepared for the pandemic. This study will be the first comprehensive examination of how HHC IPC changed from pre-pandemic to 2024, associations between IPC practices and health disparities, and will generate evidence-based recommendations to help HHC agencies for future public health infectious emergencies.

PI_NAMEs: SHANG, JINGJING  (contact);STONE, PATRICIA W.

PROGRAM_OFFICER_NAME: AKUBU-ODERO, MAUREEN KALAMBU

PROJECT_TERMS: Adult;Advocate;Affect;American;beneficiary;Caregivers;Caring;Certification;Cessation of life;Clinical;Collaborations;Communicable Diseases;Communities;Complex;Consensus;Country;COVID-19;COVID-19 burden;COVID-19 disparity;COVID-19 mortality;COVID-19 pandemic;COVID-19 risk;Data;design;Disadvantaged;Disparity;dissemination strategy;Economically Deprived Population;Elderly;Emergency Situation;Employee;Environment;ethnic minority;evidence base;evidence based guidelines;Evolution;experience;Female;Future;Guidelines;health assessment;Health Care Sector;health care service utilization;health care settings;Health Care Surveys;health disparity;Health Personnel;Healthcare;high risk;Home;Home Care Services;Home Health Care Agencies;Hospitalization;Hospitals;human old age (65+);improved;Individual;Infection;Infection Control;Infection prevention;infection risk;insight;Interview;Knowledge;Link;Literature;Measures;Medicare;Medicare claim;member;Methods;minority health;minority health disparity;Modeling;mortality;multidisciplinary;multiple chronic conditions;National Institute on Minority Health and Health Disparities;Outcome;pandemic disease;parent grant;Participant;Patient Care;patient population;Patient-Focused Outcomes;Patients;personal protective equipment;Persons;Policies;policy recommendation;Population;pre-pandemic;Procedures;Process;Public Health;Qualifying;racial minority;Readiness;Recommendation;Reduce health disparities;Reporting;Research Personnel;Review Literature;Risk;Rural Community;rural underserved;social health determinants;socioeconomic disadvantage;Source;Surveys;Time;Training;Vulnerable Populations;Work

PROJECT_TITLE: Infection Prevention in Home Health Care (InHOME)

STUDY_SECTION: HSQE

STUDY_SECTION_NAME: Health Services: Quality and Effectiveness Study Section[HSQE]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Neurosciences

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative (Relevance) This project will provide critical and detailed information regarding the brain basis of human higher cognitive functioning, such as the control of attention, and whether such functioning can be enhanced through brain electrical stimulation techniques that are low-cost, non-invasive, and safe. This information has high relevance for public health, in that it will be used to identify key neural and behavioral markers that can be used as targets in future intervention efforts directed towards individuals with mental health disorders associated with cognitive impairment (e.g., schizophrenia, dementia, autism).

PI_NAMEs: BRAVER, TODD S (contact);CHING, SHINUNG

PROGRAM_OFFICER_NAME: ROSSI, ANDREW F

PROJECT_TERMS: Address;Adult;Algorithms;Anterior;Architecture;attentional control;autism spectrum disorder;Behavior;Behavioral;Brain;brain behavior;brain control;Brain region;Cephalic;Cognitive;cognitive control;cognitive enhancement;cognitive function;cognitive neuroscience;cognitive task;Collection;computational neuroscience;control theory;cost;Data;Dementia;design;Development;directed attention;effectiveness testing;Electric Stimulation;Electrical Stimulation of the Brain;Electroencephalography;Electrophysiology (science);Engineering;Equilibrium;experience;Frequencies;Functional Magnetic Resonance Imaging;Future;Human;Impaired cognition;improved;Individual;individual variation;Influentials;Information Theory;innovation;Insula of Reil;Intervention;Literature;Mental disorders;Methodology;Methods;model building;Modeling;Nature;network models;neural;neural model;neuromechanism;neuroregulation;Neurosciences;Neurosciences Research;novel;Participant;Pattern;Performance;performance tests;Play;Policies;Population;predictive modeling;Property;Protocols documentation;psychologic;public health relevance;Regulation;Research;Rest;Risk;Sampling;Schizophrenia;spatiotemporal;Speed;System;Techniques;temporal measurement;Testing;theories;tool;Translating;Validation;Work

PROJECT_TITLE: Cognitive enhancement through model-based and individualized neurostimulation


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Brain Disorders;Genetics;Intellectual and Developmental Disabilities (IDD);Neurosciences;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_NAME: THOMAS JEFFERSON UNIVERSITY

PHR: PROJECT NARRATIVE  Childhood-onset mitochondrial disease associated with mutations in YARS2 is clinically pleiotropic, likely due to tissue-specific effects of mutations on nutrient sensing and cell signaling. To test this hypothesis, we will use the most clinically severe case known to date as a model to generate a pair of human subject-derived iPSC and control lines. Analysis of transcriptome-wide changes in gene expression specific to the subject line in iPSC- differentiated disease relevant cell types will identify the impact of YARS2 deficiency on nutrient-sensitive cell signaling as the underlying basis of the disease.

PI_NAMEs: HOU, YA-MING  (contact);IACOVITTI, LORRAINE

PROGRAM_OFFICER_NAME: BARDHAN, SUJATA

PROJECT_TERMS: Address;Affect;Alleles;Amino Acids;Amino Acyl-tRNA Synthetases;Aminoacylation;autosome;Award;bench to bedside;Biological Assay;Cell Line;Cell model;Cell Signaling Process;cell type;Central Nervous System;Charge;Childhood;Clinical;clinical diagnosis;clinical phenotype;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;Codon Nucleotides;Communities;Complex;Cytosol;Data;Dedications;Dermal;detection of nutrient;Development;Disease;disease phenotype;Disease Progression;DNA Sequence Alteration;emerging adult;enzyme activity;Enzymes;established cell line;Failure to Thrive;Family;Fibroblasts;Foundations;frontier;Functional disorder;Gene Expression;Genes;Genetic;Genotype;Health;Health Care Costs;Heterozygote;Homeostasis;Human;Human Cell Line;human disease;human subject;Impairment;Individual;induced pluripotent stem cell;infancy;insight;Intellectual functioning disability;Joints;Lactic Acidosis;Link;loss of function;Manuscripts;Mediating;Methods;Mitochondria;Mitochondrial Diseases;Mitochondrial Proteins;Modeling;Motor Neurons;Muscle Cells;Mutation;mutation correction;Myopathy;myopathy-lactic acidosis-sideroblastic anemia syndrome;Neonatal;neonate;Neuromuscular Diseases;Neurons;novel;Nuclear Family;Nutrient;Organ;Ovarian;Pathogenicity;patient derived induced pluripotent stem cells;Patients;Peripheral;Phenotype;pluripotent stem cell differentiation;Positioning Attribute;prognostication;Protein Biosynthesis;Public Health;Publishing;Pulmonary Hypertension;Recurrence;Research;Role;Secure;Sensorineural Hearing Loss;Severities;Severity of illness;Shapes;Sideroblastic Anemia;Signal Transduction;skeletal;Skeletal Muscle;Speed;Spinal;stem cell model;Stem Cell Research;Testing;Tissue Model;Tissues;transcriptome;transcriptome sequencing;Transfer RNA;Transfer RNA Aminoacylation;Translations;Tyrosine-Specific tRNA;Tyrosine-tRNA Ligase;United States National Institutes of Health;Variant;Work

PROJECT_TITLE: A cell model of YARS2-associated childhood-onset mitochondrial disease

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Developmental Biology Study Section[CHHD-C]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Disorders;Cerebrovascular;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Precision Medicine;Stroke

ORG_CITY: HOUGHTON

ORG_NAME: MICHIGAN TECHNOLOGICAL UNIVERSITY

PHR: Public Health Relevance/Narrative This R01 proposal is to investigate the feasibility of developing an innovative, non-invasive and artificial intelligence-centric tool that can be used as a software add-on to clinical angiographic (e.g. DSA) scanners. The software can automatically select high-risk aneurysms for immediate treatments from a pool of patients with unruptured intracranial aneurysms, impacting the clinical management of intracranial aneurysms.

PI_NAMEs: JIANG, JINGFENG  (contact)

PROGRAM_OFFICER_NAME: DUAN, QI

PROJECT_TERMS: 3-Dimensional;Affect;analytical method;Aneurysm;Angiography;Architecture;Artificial Intelligence;Benign;Biomedical Computing;Biomedical Engineering;blind;Brain hemorrhage;Cerebral Aneurysm;Cerebrum;Clinical;Clinical Management;Clinical Research;Clinical Trials;Computational Geometry;Computational Science;Computer Assisted;computer grid;Computer software;convolutional neural network;Data;deep learning;Development;Diagnosis;Engineering;Ensure;Evaluation;flexibility;follow-up;Genetic;Growth;hemodynamics;high risk;Human;Image;Individual;innovation;Intracranial Aneurysm;Knowledge;Liquid substance;Machine Learning;Medicine;Methods;Michigan;Morbidity - disease rate;Morphology;mortality;Natural History;Neural Network Simulation;neurosurgery;open source;Outcome;Patients;personalized management;Physics;Play;prevent;prospective;prototype;public health relevance;Research;Research Proposals;Risk;Risk Assessment;risk prediction;Role;Rupture;Ruptured Aneurysm;Secondary to;shear stress;Smoker;success;Technology;TensorFlow;Testing;tool;Training;training data;Translational Research;United States;Universities;Wisconsin;Work

PROJECT_TITLE: Personalized Management of Intracranial Aneurysms Using Computer-aided Analytics

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


NIH_SPENDING_CATS: Arthritis

ORG_CITY: LA JOLLA

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: The IKK (I kappaB Kinase) complex, a large protein complex composed of two catalytic subunits and an adapter scaffolding coiled-coil NEMO subunit that controls cellular responses to a large number of diverse extracellular and environmental stimuli to induce transcription factor NF-kappaB. This proposal will investigate how the larger assembly of the IKK complex play an essential role in signal propagation by allowing the NEMO subunit to undergo structural changes required for IKK activation. This proposal will also investigate if the peptides derived from the IKK complex can be used to control systemic inflammation and collagen induced arthritis in mouse models.

PI_NAMEs: GHOSH, GOURISANKAR  (contact)

PROGRAM_OFFICER_NAME: MALLIA, CONRAD M

PROJECT_TERMS: adaptive immune response;Affect;Arthritis;Autoimmune;Autoimmunity;Binding;Biophysics;Catalytic Domain;Cells;Chemicals;Collagen Arthritis;Complex;Coupled;Defect;dimer;Disease;drug development;efficacy testing;Event;experimental study;extracellular;Failure;fighting;Goals;Heart;IkappaB kinase;In Vitro;in vivo;Industrialization;Infection;Inflammation;Inflammatory;inhibitor;Innate Immune Response;Link;Malignant Neoplasms;Molecular Conformation;Molecular Weight;monomer;mouse model;mutant;Mutation;NF-kappa B;NFKB Signaling Pathway;novel strategies;Pathogenicity;Peptides;Pharmaceutical Preparations;Phosphorylation;Phosphotransferases;Play;Point Mutation;Polyubiquitin;potency testing;Predisposition;Process;protein complex;Protein Kinase;protein protein interaction;receptor;Regulation;Research Personnel;response;Role;scaffold;Scaffolding Protein;Serine;Signal Pathway;Signal Transduction;Specificity;Stimulus;Syndrome;systemic inflammatory response;Testing;Therapeutic;transcription factor;Transcriptional Activation;Ubiquitin

PROJECT_TITLE: Suppressing Inflammation by Blocking IKK Oligomer

STUDY_SECTION: III

STUDY_SECTION_NAME: Innate Immunity and Inflammation Study Section[III]


NIH_SPENDING_CATS: Neurosciences

ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: Project Narrative Astrocytes are critical regulators of brain function and potential therapeutic targets for a host of neurological diseases and disorders. However, our knowledge of astrocytic function is highly incomplete, and technologies are critically needed to effectively manipulate astrocyte activity with spatiotemporal precision. Developing such technologies has a broad impact to the study of the roles of astrocytes in health and disease.

PI_NAMEs: LIU, CHUNLEI  (contact);TIAN, LIN

PROGRAM_OFFICER_NAME: TYLER, WILLIAM A

PROJECT_TERMS: Action Potentials;Address;Affect;Astrocytes;Behavior;Biochemical;Biophysics;Brain;Calcium;Calcium Signaling;Cations;Cell Membrane Permeability;cell type;Cells;Chronic;Complex;Coupled;Development;Disease;Electromagnetic Fields;Engineering;Event;Family;Ferritin;Foundations;Glutamates;Goals;Health;Heating;Image;improved;In Vitro;in vivo;Ion Channel;Ions;Iron;Knowledge;Mediating;Membrane;Membrane Proteins;Modeling;Modernization;Molecular;Morphologic artifacts;Names;Nervous System Disorder;neural;neural circuit;Neurodegenerative Disorders;neuronal circuitry;Neurons;neuropsychiatric disorder;neurotransmitter release;Neurotransmitters;new therapeutic target;Outcome;Pattern;Permeability;Physiological;Proteins;radio frequency;Regulation;Research;Role;Signal Transduction;sound;Source;spatiotemporal;Supporting Cell;Synapses;synaptic function;Synaptic Transmission;Techniques;Technology;therapeutic target;Tissues;tool;Treatment Efficacy;TRP channel;two-photon;wireless

PROJECT_TITLE: Genetically-Encoded, Non-Invasive and Wireless Modulation of Calcium Dynamics in Astrocytes With Spatiotemporal Precision and Depth

STUDY_SECTION: CMT

STUDY_SECTION_NAME: Cellular and Molecular Technologies Study Section[CMT]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: CHARLESTON

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: Overall – Project Narrative Gastrointestinal diseases are a tremendous burden for many US citizens with treatment costs estimated to be more than $120 billion annually in the US. This initiative will establish a center of excellence in digestive and liver disease research in South Carolina where the population bears a disproportionate burden of disease.

PI_NAMEs: DUNCAN, STEPHEN A (contact)

PROGRAM_OFFICER_NAME: KOVBASNJUK, OLGA NIKOLAEVNA

PROJECT_TERMS: American;animal facility;Animal Model;Area;Basic Science;Biomedical Research;burden of illness;career;career development;Cell Culture Techniques;Cell model;Cells;Centers of Research Excellence;Clinical Research;Collaborations;college;cost estimate;Department chair;Development;Digestive System Disorders;Disease;Equipment;Evaluation;Faculty;Fibrosis;Fostering;Foundations;Funding;Future;gastrointestinal;Gastrointestinal Diseases;Gnotobiotic;Goals;Grant;Image;Imaging technology;improved;Inflammation;Infrastructure;innovation;Institution;Investments;Left;Liver;Liver diseases;Malignant neoplasm of gastrointestinal tract;Malignant Neoplasms;Medical;Medical center;Medicine;member;Mentors;Metabolic Diseases;Metabolism;Mission;Modeling;Molecular;multidisciplinary;novel;Peer Review;Pilot Projects;Population;programs;recruit;Reporting;Research;Research Personnel;Research Support;Resources;Scientist;Series;Source;South Carolina;success;Talents;Technology;tissue culture;Tissues;Training;Translational Research;Treatment Cost;United States National Institutes of Health;Universities;Vision;Writing

PROJECT_TITLE: COBRE in Digestive & Liver Disease


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Digestive Diseases;Liver Disease

PROJECT_TERMS: Accountability;Address;Advisory Committees;Basic Science;Biomedical Research;Biometry;Biostatistical Methods;career;career development;Centers of Research Excellence;Collaborations;Development;Development Plans;Digestive System Disorders;Effectiveness;Elements;Ensure;Evaluation;experimental analysis;Experimental Designs;Extramural Activities;Faculty;Fostering;Funding;Future;Gastrointestinal Diseases;Goals;Individual;Information Dissemination;Infrastructure;Institution;Leadership;Liver diseases;Medical;Mentors;Monitor;multidisciplinary;novel;operation;Peer Review;Pilot Projects;Program Evaluation;programs;Recommendation;recruit;remediation;Reproducibility;Research;Research Personnel;Research Project Grants;Resources;Scheme;Scientist;Series;Services;sound;Source;South Carolina;success;synergism;Teacher Professional Development;Training;Universities

PROJECT_TITLE: Administrative & Mentoring Core


NIH_SPENDING_CATS: Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Digestive Diseases;Liver Disease;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PROJECT_TERMS: Adopted;Affect;Animal Disease Models;Biological Models;Cell Culture Techniques;Cell Differentiation process;Cell Line;Cell Maintenance;Cell model;cell type;Cells;Centers of Research Excellence;cholangiocyte;Collaborations;Colon;Communities;CRISPR/Cas technology;Data;Development;Digestive System Disorders;directed differentiation;DNA Sequence Alteration;Drug Screening;Ensure;Enteroendocrine Cell;Epithelial Cells;established cell line;Evaluation;experience;experimental study;Feedback;Funding;Future;Gastrointestinal tract structure;gene editing technology;Gene Modified;Generations;genetically modified cells;Genome engineering;Goals;Goblet Cells;Hepatocyte;human induced pluripotent stem cells;human pluripotent stem cell;Implant;in vivo;induced pluripotent stem cell;innovation;intestinal epithelium;Investigation;Laboratories;Leadership;Liver;Liver diseases;Medical;medical schools;Mentors;Mesenchyme;Modeling;Molecular;mouse model;Mutate;Mutation;Needs Assessment;new technology;operation;Organoids;Paneth Cells;Performance;Printing;Procedures;Production;professor;Program Evaluation;programs;Protocols documentation;Reagent;recruit;Reproducibility;Research;Research Personnel;Resources;Running;Self-Examination;Services;South Carolina;stable cell line;stem cell biology;stem cells;Surveys;System;Technical Expertise;Technology;tissue culture;Tissues;tool;Training;training opportunity;Universities;Wisconsin;Work

PROJECT_TITLE: Cell Models Core


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Brain Disorders;Cannabinoid Research;Cerebrovascular;Childhood Injury;Conditions Affecting the Embryonic and Fetal Periods;Endocannabinoid System Research;Fetal Alcohol Spectrum Disorders (FASD);Intellectual and Developmental Disabilities (IDD);Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Stroke;Substance Misuse

ORG_CITY: MEMPHIS

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF TENNESSEE HEALTH SCI CTR

PHR: Fetal alcohol spectrum disorders (FASD) is a leading preventable cause of mental retardation in the United States that develops in children whose mothers engaged into considerable alcohol consumption during pregnancy. Currently, there is no readily available cure for FASD, and the goal of our research is to establish the role of alcohol damage to fetal brain vessels in development of this pathology. If successful, our research will introduce a much needed pathway for therapeutic intervention(s) against FASD.

PI_NAMEs: BUKIYA, ANNA  (contact)

PROGRAM_OFFICER_NAME: DUNTY, JR, WILLIAM

PROJECT_TERMS: Ablation;Accidents;Address;Affect;alcohol consumption during pregnancy;alcohol exposure;alcohol response;Alcohols;Animal Model;Area;Attention;Autopsy;binge drinking;Blood;Blood alcohol level measurement;Blood Vessels;blood-brain barrier function;Brain;Brain hemorrhage;Brain Hypoxia-Ischemia;Brain Ischemia;Cannabinoids;cerebral artery;cerebral vascularization;cerebrovascular;Cerebrovascular Circulation;Cerebrovascular system;Cerebrum;Child;Circulation;Clinical;CNR1 gene;CNR2 gene;Craniofacial Abnormalities;cranium;Data;Development;diagnostic criteria;Diameter;Doppler Ultrasonography;Drops;Endocannabinoids;endogenous cannabinoid system;Excision;Exhibits;fetal;Fetal Alcohol Exposure;Fetal Alcohol Spectrum Disorder;Fetal Growth;Fetal Heart;Fetal Skull;Fetus;Functional disorder;Geographic Locations;Goals;Growth;Harvest;Head circumference;Human;In Vitro;in vivo;Incidence;Individual;Infant;Intracranial Hypotension;Knowledge;Laboratories;liquid chromatography mass spectrometry;Mass Spectrum Analysis;maternal alcohol use;Mediating;Mental Retardation;Modeling;Modification;Morphology;Mothers;mouse model;neuron apoptosis;neuron development;neuron loss;Neurons;nonhuman primate;Nutritional;Organ;Oxygen;Papio;Pathogenesis;Pathologic;Pathology;Pathway interactions;peer;pharmacologic;Play;Pregnancy;prenatal;pressure;Prevalence;Proteomics;receptor;Recording of previous events;Reporting;Research;response;Role;Sheep;South Africa;System;Testing;Therapeutic;therapeutic development;Therapeutic Intervention;Tissues;United States;Vasodilation;wasting;Weight;Work;Youth

PROJECT_TITLE: Fetal cerebral arteries and prenatal alcohol exposure

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Building Research Capacity at Institutions with Limited NIH Funding;Digestive Diseases;Liver Disease

PI_NAMEs: LEMASTERS, JOHN J (contact)

PROJECT_TERMS: Animals;Apoptosis;Award;Biological Sciences;cell fixing;Cell Membrane Permeability;Cell Survival;Cells;Centers of Research Excellence;Clinical;Communities;Computer software;Computer Workstations;Consultations;Data;Data Analyses;Detection;Digestive System Disorders;digital imaging;Education;electrical potential;Ensure;Equipment;fluorescence microscope;Fluorescence Resonance Energy Transfer;fluorophore;Gases;Gene Expression;Generations;Goals;Grant;high resolution imaging;histological image;histological slides;Image;image processing;imaging approach;imaging modality;imaging system;Imaging technology;Immersion;immunocytochemistry;Individual;intravital imaging;intravital microscopy;Ions;Laboratories;Lasers;Leukocytes;liquid crystal polymer;live cell imaging;Liver diseases;Medicine;Mentors;Microcirculation;Microscope;microscopic imaging;Microscopy;Mission;Mitochondria;Monitor;multi-photon;multiphoton microscopy;multiplexed imaging;Necrosis;next generation;Optics;Organism;Pathology;pathology imaging;Permeability;Phase;Preparation;protein distribution;Proteins;pyridine nucleotide;quasar;Reporter;Research;Research Personnel;Scanning;Services;Silicone Oils;Slide;Specimen;submicron;success;superresolution microscopy;System;Technology;Temperature;Three-Dimensional Imaging;Time;Tissue imaging;Tissues;Training;ultra high resolution;Water;Work

PROJECT_TITLE: Advanced Imaging Core


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Muscular Dystrophy;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: DURHAM

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: DUKE UNIVERSITY

PHR: Project Narrative We will develop a 3D ultrasonic shear wave elasticity imaging system and use it to non-invasively measure the mechanical properties of skeletal muscle and to determine their relationship to muscle health; this system will ultimately be used to assess muscular deﬁcits associated with neuromuscular diseases and to determine how well therapeutic treatments are working and when they should be modiﬁed, which will both improve treatment efﬁcacy and reduce the number of muscle biopsies performed in these patients.

PI_NAMEs: NIGHTINGALE, KATHRYN RADABAUGH (contact)

PROGRAM_OFFICER_NAME: KING, RANDY LEE

PROJECT_TERMS: 3-Dimensional;Acoustics;Adoption;Affect;Age;Algorithms;Anisotropy;Behavior;Biological Markers;biomarker development;biomechanical test;Biomechanics;Biopsy;Breast;Calibration;Cessation of life;Clinic;Clinical;Clinical Research;Clinical Trials;comorbidity;Complex;Consumption;cost;Data;data acquisition;Diagnosis;disability;Disease;disease diagnosis;Disease Management;Disease Progression;Dual-Energy X-Ray Absorptiometry;Duchenne muscular dystrophy;efficacy evaluation;Elastic Tissue;Elasticity;elastography;enzyme therapy;Exclusion;Fiber;Gender;gene therapy;Geometry;Glycogen storage disease type II;Health;Height;Heterogeneity;Image;image reconstruction;imaging approach;imaging modality;imaging system;Imaging technology;improved;in vivo;Isotropy;Lesion;Liver Fibrosis;Magnetic Resonance Imaging;Measurement;Measures;mechanical properties;Medical;Methods;Modeling;Modulus;Monitor;Muscle;Muscle Fibers;Muscle function;muscle strength;Muscular Dystrophies;Musculoskeletal;Musculoskeletal System;Myopathy;Nature;Neuromuscular Diseases;novel;novel therapeutics;Outcome Measure;Pain;Pathology;Patient Compliance;Patient Participation;Patients;Performance;personalized medicine;portability;primary outcome;Procedures;Property;Prostate;prototype;Radiation;reconstruction;Replacement Therapy;Reporting;Research;Risk;Sampling;Scanning;screening;sex;side effect;skeletal disorder;Skeletal Muscle;soft tissue;Speed;Staging;success;System;Testing;Therapeutic;Therapeutic Intervention;Thyroid Gland;Time;tool;Treatment Efficacy;treatment response;Ultrasonics;Ultrasonography;ultrasound;viscoelasticity;Viscosity;Walking;Weight;X-Ray Computed Tomography

PROJECT_TITLE: 3D Shearwave Elasticity Biomarker Development for Neuromuscular Disease

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Digestive Diseases;Liver Disease;Microbiome

PI_NAMEs: CRAIG, SUZANNE L (contact)

PROJECT_TERMS: American;Animal Experimentation;animal facility;Animal Model;animal resource;Animals;Area;bile duct;Biological Products;Biomedical Research;Caring;Catheters;Cells;Centers of Research Excellence;Chemicals;Cirrhosis;Complex;Core Facility;Data;Diet;Digestive System Disorders;disease model;driving force;Educational workshop;Environment;experience;Extramural Activities;Faculty;Feedback;Fibrosis;follow-up;Funding;Future;gastrointestinal system;Generations;Genetic;Germ-Free;Gnotobiotic;Housing;implantation;in vivo;in vivo Model;Individual;Inflammation;Knowledge;Laboratories;Laboratory Animals;Laboratory mice;Life;Ligation;Liver diseases;Malignant Neoplasms;Medical;meetings;member;Mentors;Mentorship;Metabolic Diseases;microbiome;microbiome research;microorganism;Modeling;Modification;Mus;Needs Assessment;Operative Surgical Procedures;Organoids;Osmosis;Partial Hepatectomy;Performance;Procedures;Pump;Research;Research Infrastructure;Research Personnel;Research Project Grants;Resources;Services;skills;South Carolina;Surveys;Technology;tool;Training;Universities;Update;Work

PROJECT_TITLE: Animal Models of Digestive Disease Core


NIH_SPENDING_CATS: Infectious Diseases;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative Congenital infection with cytomegalovirus (CMV) is a leading cause of childhood deafness and permanent neurologic impairment worldwide, with approximately 40,000 cases occurring annually in the U.S. This project will include detailed studies of CMV-specific immunity in infants infected in utero and in early childhood and will identify immune correlates of viral control and clinical sequelae. Insights from these studies will lead to a better understanding of the cellular and molecular immune processes that underlie the age-related vulnerability of the human fetus to viral infection.

PI_NAMEs: FEENEY, MARGARET E (contact)

PROGRAM_OFFICER_NAME: PRABHUDAS, MERCY R

PROJECT_TERMS: Adult;age difference;age related;Anti-viral Response;Antigens;arm;Biological Assay;Birth;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Physiology;Cells;Cellular Immunity;Child;Childhood;Chronic;chronic infection;Clinical;Clinical Data;cohort;congenital cytomegalovirus;congenital infection;Containment;Coupled;Critical Pathways;Cytomegalovirus;Cytomegalovirus Infections;Cytometry;cytotoxic CD8 T cells;Data;deafness;Development;differential expression;early childhood;Effector Cell;Epigenetic Process;Exhibits;fetal;Fetal Development;fetal programming;Fetus;Genetic Transcription;Granzyme;Growth;high dimensionality;Host Defense;Human;Immune;Immune response;Immune system;Immunity;Immunologics;Immunology;Impairment;in utero;Individual;infancy;Infant;infant infection;Infection;innovation;insight;inter-individual variation;Life;Measures;Mediating;Memory;Microcephaly;Modeling;Molecular;Mothers;mouse model;multimodality;Neonatal;neonatal infection;neonatal mice;neonate;Neurologic;Outcome;pathogen;Peripheral Blood Mononuclear Cell;Phenotype;Plasma;Play;Population;postnatal;precursor cell;Pregnancy;Primary Infection;Process;programs;prospective;Resolution;response;Role;Sampling;stem;stem-like cell;Symptoms;System;T cell receptor repertoire sequencing;T cell response;T-Cell Development;T-Lymphocyte;Testing;Thymus Gland;Time;Toddler;transcriptomics;Umbilical Cord Blood;Viral;Viral Load result;Viral Physiology;Viremia;Virus Diseases;Virus Replication;Virus Shedding

PROJECT_TITLE: T cell immunity to CMV in utero and in early childhood


NIH_SPENDING_CATS: Clinical Research;Immunotherapy;Infectious Diseases;Prevention;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: Project Narrative Cytomegalovirus (CMV) infection causes an increased risk of complications and death after hematopoietic cell transplantation. Recent studies suggest that new medications for the prevention of graft-versus-host disease (GVHD) after transplant may promote the development of immunity against CMV; however, it is unclear whether these new GVHD preventative drugs can promote CMV immunity in the era of modern CMV prevention. This proposal will seek to answer this question, using cutting edge technology and analytical methods, in order to inform management of CMV in the context of new and future cancer treatments.

PI_NAMEs: ZAMORA, DANNIEL  (contact)

PROGRAM_OFFICER_NAME: DUPUY, LESLEY CONRAD

PROJECT_TERMS: advanced analytics;Affect;Allogenic;analytical method;Animals;Antibodies;antibody detection;Antibody Response;Antibody-mediated protection;antigen-specific T cells;Biological Assay;Calcineurin inhibitor;cancer therapy;Cells;Cellular Immunity;Cessation of life;Clinical;clinically relevant;clinically significant;Cohort Studies;combinatorial;Computing Methodologies;Cyclophosphamide;Cytomegalovirus;Cytomegalovirus Infections;Data;Development;Epitopes;Event;exhaustion;Future;graft vs host disease;Hematopoietic Stem Cell Transplantation;human pathogen;Humoral Immunities;Immune;immune reconstitution;Immune response;Immunity;Immunologic Monitoring;Immunologics;Immunotherapy;improved;in vitro Assay;infection risk;Kinetics;Measures;Methods;Modernization;neutralizing antibody;novel;Outcome;pathogen;Pattern;Pharmaceutical Preparations;post-transplant;prevent;Prevention;Prophylactic treatment;prospective;Prospective cohort;reconstitution;Recovery;Regimen;Regulatory T-Lymphocyte;Risk;Role;Serology;Sirolimus;T cell reconstitution;T cell response;T-Lymphocyte;T-Lymphocyte Subsets;Techniques;Technology;Transplant Recipients;Transplantation;Viral;Viral Load result;virome;Virus

PROJECT_TITLE: Cytomegalovirus-specific Immune Reconstitution after Hematopoietic Cell Transplantation in the Era of Modern Antiviral Prophylaxis

STUDY_SECTION: AITC

STUDY_SECTION_NAME: Allergy, Immunology, and Transplantation Research Committee[AITC]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Sleep Research;Social Determinants of Health

ORG_CITY: SANTA MONICA

ORG_NAME: RAND CORPORATION

PHR: Project Narrative African Americans (AAs) have significantly higher rates and earlier onset of Alzheimer’s disease and related dementias (ADRD) relative to White Americans; however, we lack a thorough understanding of how individual and neighborhood factors and their changes over the lifecourse contribute to ADRD risk in AAs. The current proposal capitalizes on an ongoing, longitudinal study to examine the impact of changing neighborhood conditions and the role of risk and protective factors in the lived experience of AAs and their influence on cognitive function and ADRD risk.

PI_NAMEs: DUBOWITZ, TAMARA  (contact);ROSSO, ANDREA L;TROXEL, WENDY M

PROGRAM_OFFICER_NAME: BANDIERA, FRANK

PROJECT_TERMS: adjudication;Adult;adverse childhood events;African American;African American population;Age Distribution;aged;Alzheimer's disease related dementia;Alzheimer's disease risk;biobehavior;Blood Pressure;cardiometabolic risk;cardiometabolism;caucasian American;Clinical;Cognitive;Cognitive aging;cognitive change;cognitive function;cognitive testing;cohort;Cohort Studies;Communities;community based research;Data;dementia risk;design;Development;Diabetes Mellitus;Diagnosis;Disadvantaged;Discrimination;Disparity;Early identification;Early Onset Alzheimer Disease;Economic Conditions;Education;Enrollment;experience;Exposure to;Fostering;Funding;Health;Health and Retirement Study;Heterogeneity;Household;Housing;Impaired cognition;Individual;Inequity;Intervention;Interview;Investments;land use;late life;Life;Life Cycle Stages;Lived experience;Longitudinal cohort;Longitudinal Studies;Low income;marginalization;Measures;Mediating;Mediator;Methods;middle age;Natural experiment;neighborhood disadvantage;Neighborhoods;Outcome;Participant;Pattern;Policies;Poverty;Prevention;protective factors;psychologic;Questionnaires;Race;racial disparity;racial health disparity;Recording of previous events;Research;Research Infrastructure;resilience factor;response;Rest;Risk;Risk Factors;Role;Safety;Sampling;satisfaction;Science;segregation;Sleep;Sleep disturbances;social;social cohesion;sociodemographics;socioeconomic disparity;socioeconomics;stressor;Structural Racism;Time;Trauma;Urban Renewal;Variant;vigilance

PROJECT_TITLE: Longitudinal Examination of Neighborhood Disadvantage, Cognitive Aging, and Alzheimer's Disease Risk in Disinvested, African American Neighborhoods

STUDY_SECTION: NAME

STUDY_SECTION_NAME: Neurological, Aging and Musculoskeletal Epidemiology Study Section[NAME]


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Neurosciences;Prevention

ORG_CITY: STANFORD

ORG_DEPT: PATHOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: PUBLIC HEALTH RELEVANCE STATEMENT Identifying causal genetic variants in mental health disease is a major challenge limiting interpretation of disease biology, prediction of risk and development of therapies. Our work will develop computational approaches to identify these variants, interpret molecular disease mechanisms and predict individual risks.

PI_NAMEs: KUNDAJE, ANSHUL ;MONTGOMERY, STEPHEN  (contact);RIVAS, MANUEL A

PROGRAM_OFFICER_NAME: PEVSNER, JONATHAN ABRAM

PROJECT_TERMS: Acute;Affect;Alleles;Alzheimer's Disease;base;biobank;Biological Assay;Biology;Brain;brain cell;Brain region;Catalogs;causal variant;cell type;Cells;Chromatin;Collaborations;Communities;computational pipelines;Computer software;Computing Methodologies;Data;Databases;deep learning model;Detection;Development;Disease;disorder risk;DNA Sequence;epigenome;epigenomics;experimental study;functional genomics;Future;Gene Expression;Gene Expression Regulation;Gene Frequency;Genes;Genetic;Genetic Diseases;Genetic Load;Genetic Risk;genetic variant;Genetic Variation;genome resource;genome wide association study;genomic locus;Genotype-Tissue Expression Project;Human;improved;Individual;Influentials;insight;Learning;Link;Linkage Disequilibrium;Machine Learning;machine learning method;machine learning model;Maps;Masks;Mental disorders;Mental Health;Mental Health Associations;Methods;Modeling;Molecular;Molecular Disease;Mus;National Human Genome Research Institute;Neurodevelopmental Disorder;novel;novel strategies;open data;Organoids;Outcome;Parkinson Disease;Pathologic;Performance;polygenic risk score;Population;prevent;public health relevance;Quantitative Trait Loci;regression algorithm;Reporter;Reproducibility;Research;Resolution;Resources;Risk;risk prediction;single cell ATAC-seq;success;therapy development;Tissue Sample;Tissues;Training;trait;Uncertainty;Untranslated RNA;Variant;Weight;Work

PROJECT_TITLE: Identifying causal genetic variants and molecular mechanisms impacting mental health


NIH_SPENDING_CATS: Autoimmune Disease;Brain Disorders;Genetics;Multiple Sclerosis;Neurodegenerative;Neurosciences

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: The goal of this proposal is to define the role of the SigmaR1-IRE1a-XBP1 signaling axis in astrocytes during CNS inflammation. To achieve this goal, we propose to apply spatial transcriptomics, scRNA-seq, and genetic and pharmacologic perturbations to the analysis of MS patient samples and murine disease models. In summary, this project investigates a novel molecular pathway in astrocytes using cutting edge techniques to define basic mechanisms that control CNS inflammation and identify novel therapeutic targets.

PI_NAMEs: WHEELER, MICHAEL ALEX (contact)

PROGRAM_OFFICER_NAME: UTZ, URSULA

PROJECT_TERMS: Animal Model;Astrocytes;Autoimmune Responses;Binding Proteins;Blood - brain barrier anatomy;Cells;Cellular Stress;Central Nervous System;Central Nervous System Diseases;Chronic;clinically relevant;cost;Data;Development;disability;Disease;disease model;Economic Burden;efficacious treatment;Endoplasmic Reticulum;Environmental Pollutants;Environmental Risk Factor;Enzymes;Experimental Autoimmune Encephalomyelitis;Factor X;Gene Expression;Genetic;Genetic Transcription;Goals;Granulocyte-Macrophage Colony-Stimulating Factor;Granulocyte-Macrophage Colony-Stimulating Factor Receptors;Health;Herbicides;Homeostasis;Human;immune cell infiltrate;Inflammation;Inflammatory;inhibitor;Inositol;Lesion;Link;Mediating;Mentors;Metabolic Control;Microglia;Modeling;Molecular;monocyte;mouse model;Multiple Sclerosis;Multiple Sclerosis Lesions;multiple sclerosis patient;Mus;Myelin;Natural Immunity;Nerve Degeneration;Nervous System Disorder;Nervous System Physiology;Neurodegenerative Disorders;Neuroglia;Neurologic Deficit;Neurons;neurotoxic;new therapeutic target;novel;Pathogenesis;Pathogenicity;Pathway interactions;Peptide Initiation Factors;pharmacologic;Phase;Play;Population;programs;Proteins;receptor;receptor expression;recruit;Refractory;Regulation;Research Personnel;response;Role;Sampling;Signal Pathway;Signal Transduction;single-cell RNA sequencing;small molecule;synergism;T-Cell Activation;T-Lymphocyte;targeted treatment;Techniques;Therapeutic;therapeutic evaluation;Therapeutic Intervention;therapeutic target;therapy development;transcription factor;Transcriptional Activation;transcriptomics;translational potential;Work;young adult

PROJECT_TITLE: Molecular Control of Astrocytes in CNS Inflammation


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Mental Illness;Neurosciences;Schizophrenia

ORG_CITY: Nashville

ORG_NAME: VANDERBILT UNIVERSITY

PHR: PROJECT NARRATIVE Our research determines how newly designed muscarinic drug compounds enhance cognition, motivation, and problem solving with high efficacy and without dose-limiting side effects that accompany existing drugs. Our research will elucidate how these drug-induced pro-cognitive and pro-motivational effects relate to neurochemical and activity changes of interneurons in the prefrontal cortex and the striatum. The results have the potential to identify the cell-type specific mechanisms with which advanced novel drug compounds enhances cognition and motivation, thereby proposing novel treatment strategies for mental disorders.

PI_NAMEs: WOMELSDORF, THILO  (contact)

PROGRAM_OFFICER_NAME: HUPALO, SOFIYA

PROJECT_TERMS: Acetylcholine;Address;Affect;affective disturbance;Agonist;Anhedonia;Animals;Anterior;Antipsychotic Agents;Area;Attention;attentional control;Behavior;Behavior assessment;behavior prediction;Behavioral;Benchmarking;Binding;Brain;cell type;Chemicals;Choline;cholinergic;Cholinergic Agents;cingulate cortex;Clinical;Cognition;Cognitive;Cognitive deficits;cognitive enhancement;cognitive function;cognitive task;cognitive testing;Complement;Complex;Consensus;Corpus striatum structure;Data;design;donepezil;Dopamine;Dose;Dose Limiting;drug action;Drug Compounding;drug discovery;Drug Modulation;Drug usage;Electrophysiology (science);extracellular;Fingerprint;flexibility;frontal lobe;gamma-Aminobutyric Acid;Glutamates;Home;Human;improved;in vivo;insight;Interneurons;Lead;Learning;Macaca mulatta;MATRICS Consensus Cognitive Battery;Measures;Mediating;memory process;Mental disorders;Microdialysis;Motivation;multitask;Muscarinic Acetylcholine Receptor;Muscarinic M1 Receptor;Muscarinic M2 Receptor;Muscarinic M3 Receptor;Muscarinics;neural;neurochemistry;Neuromodulator;neurophysiology;nonhuman primate;novel;novel therapeutics;Outcome;Patients;Peripheral;Pharmaceutical Preparations;Phase;positive allosteric modulator;Prefrontal Cortex;Primates;Problem Solving;Process;Psychoses;receptor;receptor density;Regulation;Research;Research Domain Criteria;resilience;response;Rest;Rewards;Sampling;Schizophrenia;Serotonin;Short-Term Memory;side effect;Signal Transduction;skills;Solid;Symptoms;Synapses;Task Performances;Testing;Therapeutic Index;touchscreen;Training;treatment strategy;Up-Regulation;Visuospatial;xanomeline

PROJECT_TITLE: Muscarinic modulation of RDoC constructs in primate behavior and fronto-striatal circuits

STUDY_SECTION: MNPS

STUDY_SECTION_NAME: Molecular Neuropharmacology and Signaling Study Section[MNPS]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cocaine;Drug Abuse (NIDA only);Genetics;Neurosciences;Stimulant Use and Misuse;Substance Misuse;Women's Health Research

ORG_DEPT: PSYCHIATRY

PHR: PROJECT NARRATIVE Women are more vulnerable to the rewarding effects of cocaine and more rapidly progress from initial  use to dependence than men but the neurobiological mechanisms that contribute to these differences yet to be  determined. This project will use a combination of single-cell transcriptomics, blood hormone level assays,  pharmacology, and RNAscope to investigate how sex steroids and nicotinic acetylcholine receptors (nAChRs)  alpha 5 (α5) contribute to sex differences in cocaine self-administration. The overall goal of this project is to  identify the effects of a history of cocaine self-administration on sex steroids and nAChRs expression and to test  the hypothesis that decreased nAChR α5 in the dHIPP produced by decreased progesterone levels promote  cocaine self-administration.

PI_NAMEs: SNEDDON, ELIZABETH  (contact)

PROGRAM_OFFICER_NAME: LOSSIE, AMY C

PROJECT_TERMS: addiction;Address;Adrenal Glands;Affect;Age;Alcohol consumption;Alcohol dependence;alcohol exposure;alcohol misuse;alcohol seeking behavior;alcohol use disorder;Alcohols;Automobile Driving;Behavior;Bioinformatics;Biological Assay;Blood;Brain;Brain region;Calcium;Catheters;Cells;Cessation of life;cholinergic;Chronic;Clozapine;Cocaine;Cocaine Dependence;cocaine self-administration;compulsion;Consumption;Darkness;Data;Dependence;design;designer receptors exclusively activated by designer drugs;Dorsal;drinking;drinking behavior;Drug abuse;Drug Exposure;drug of abuse;Enzyme-Linked Immunosorbent Assay;Ethanol;experimental study;Female;Fiber;Four Core Genotypes;Genetic;Genetic Transcription;Glutamate Receptor;Glutamates;Goals;Gonadal Hormones;Gonadal Steroid Hormones;Gonadal structure;Hippocampus;Home;Hormonal;Hormones;Image;Individual;innovation;Institution;Intake;Investigation;knock-down;Knowledge;Knowledge acquisition;Ligands;Literature;male;men;Mentors;Modeling;mouse model;mRNA Expression;Mus;N-Methyl-D-Aspartate Receptors;neural circuit;neurobiological mechanism;Neurobiology;Neuroendocrinology;neuromechanism;Neuronal Plasticity;Neurons;Neurosciences;Nicotinic Receptors;NMDA receptor antagonist;Nose;Nucleus Accumbens;Operative Surgical Procedures;optogenetics;Overdose;Oxides;Pattern;Pharmacology;Phase;Phenotype;Photometry;Pituitary Gland;Population;post-doctoral training;Postdoctoral Fellow;pre-clinical research;pre-doctoral;Progesterone;Progesterone Receptors;programs;protein expression;Quinine;Rattus;receptor;receptor expression;Recording of previous events;reproductive organ;Research;Research Personnel;Research Project Grants;Reverse Transcriptase Polymerase Chain Reaction;reward circuitry;Rewards;Rodent;Role;Sampling;Schedule;Self Administration;sex;Sex Chromosomes;Sex Differences;skills;small hairpin RNA;Substance Use Disorder;System;Techniques;Testing;Tissues;tool;Training;transcriptomics;United States;vapor;Viral Vector;Vulnerable Populations;Western Blotting;Withdrawal;Woman;Work

PROJECT_TITLE: Investigation of how sex steroids and nicotinic acetylcholine receptors promote cocaine self-administration


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Digestive Diseases;Pancreatic Cancer;Rare Diseases

PI_NAMEs: HOBBS, GUY  (contact)

PROJECT_TERMS: 3-Dimensional;Address;Biological Assay;Biological Models;Biotin;Cancer Model;Cell model;Cells;Centers of Research Excellence;Digestive System Disorders;Environment;genomic locus;KRAS2 gene;KRASG12D;Ligation;Liver diseases;Malignant neoplasm of pancreas;Maps;mouse model;Mus;mutant;Mutation;neoplastic;Oncogenic;Organoids;Pancreas;Pancreatic Ductal Adenocarcinoma;Pathway interactions;Patients;Predisposition;Proteins;Proto-Oncogenes;Signal Pathway;Signal Transduction;Survival Rate;Therapeutic;therapeutically effective;Work

PROJECT_TITLE: Defining the KRAS mutation specific interactions in pancreas cancer


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Climate-Related Exposures and Conditions;Clinical Research;Contraception/Reproduction;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Neurosciences;Pediatric;Pregnancy;Social Determinants of Health;Women's Health Research

PHR: PROJECT NARRATIVE Prenatal traffic-related air pollution (TRAP) exposure has been consistently linked with altered child neurodevelopment, and placental dysfunction is central to these effects. We propose the first study on the impact of TRAP on the placenta N6-methyladenosine (m6A) epitranscriptome and the ensuing effects on child neurodevelopment, using both population-based and mechanistic approaches. Our focus on the placenta an extraembryonic tissue that is key to early-life neurodevelopmental programming will lead to novel insight into the mechanisms governing the effects of prenatal TRAP exposure and child neurodevelopment and may uncover new molecular targets for prevention and treatment.

PI_NAMEs: HERBSTMAN, JULIE BETH (contact);MASON, CHRISTOPHER EDWARD;WU, HAOTIAN

PROGRAM_OFFICER_NAME: TYSON, FREDERICK L

PROJECT_TERMS: Address;Age;Air Pollutants;ambient air pollution;Animals;Attention;Biological;Blood;Brain;Carbon Black;Child;Cognition;cohort;Data;design;Development;embryo tissue;Environment;Environmental Exposure;epitranscriptome;epitranscriptomics;executive function;experimental study;Exposure to;fetal;Fetal Development;Fetal Growth;follow-up;Functional disorder;Future;Genetic Transcription;Hispanic;Human;In Vitro;in vitro Model;innovation;insight;Intelligence;Intelligence Tests;Intervention;Life;Link;Low income;Measures;Mediating;Mediator;Mental Health;Messenger RNA;Methods;Modification;Molecular Target;Mothers;Names;neurodevelopment;neurodevelopmental effect;Neuropsychological Tests;Neurosecretory Systems;neurotoxicity;novel;novel strategies;Organ;Pathway Analysis;Pathway interactions;Performance;Placenta;Placentation;population based;Post-Transcriptional RNA Processing;postnatal;Pregnancy;prenatal;prenatal influence;Prevention;protein expression;Proteins;Reader;recruit;Regulation;Reporting;Research;RNA Splicing;RNA Stability;RNA, Messenger, Splicing;Role;Series;Short-Term Memory;Siblings;Signal Transduction;Therapeutic;therapeutic target;Time;Tissues;toxicant;traffic-related air pollution;Translations;trophoblast;Work

PROJECT_TITLE: Prenatal Traffic-Related Air Pollutants, Placental Epitranscriptomics, and Child Cognition

STUDY_SECTION: BGES

STUDY_SECTION_NAME: Behavioral Genetics and Epidemiology Study Section[BGES]