NIH_SPENDING_CATS: Bioengineering;Biotechnology;Eye Disease and Disorders of Vision;Gene Therapy;Genetics;Nanotechnology;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: MADISON

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE A nonsense mutation is a point mutation in the DNA sequence that deleteriously stops healthy protein synthesis prematurely, accounting for about 11% of inherited blindness. One such group of proteins are ion channels that are present in the cell membrane to facilitate cellular communication. Our project focuses on a novel small gene therapy that can be easily delivered to the retina to establish normal function and therefore treat blindness caused by ion channel nonsense mutation.

PI_NAMEs: AHERN, CHRISTOPHER A;GAMM, DAVID M;GONG, SHAOQIN -;PATTNAIK, BIKASH RANJAN (contact)

PROGRAM_OFFICER_NAME: GOVER, TONY DOUGLAS

PROJECT_TERMS: Accounting;Address;adenovirus mediated delivery;Amino Acids;Anatomy;Anticodon;base;Biochemical;Biological Assay;Biological Availability;Biological Models;Blindness;Cell Differentiation process;Cell membrane;cell type;Cells;Childhood;Clinical Trials;Communication;Communities;Complex;Cone dystrophy;Cultured Cells;Data;Defect;Development;Disease;disease phenotype;DNA;DNA Sequence;Drug Delivery Systems;Drug Targeting;efficacious treatment;Electrophysiology (science);Engineering;Evaluation;Eye;Eye diseases;FDA approved;functional outcomes;gene therapy;Genes;Genetic Diseases;genome editing;Glutamine;Human;human disease;human induced pluripotent stem cells;human pluripotent stem cell;In Vitro;in vivo;Incidence;induced pluripotent stem cell;Inherited;intravitreal injection;Ion Channel;Ion Channel Protein;Iowa;Libraries;Light;Location;Membrane Proteins;Methods;Missense Mutation;Molecular;Monitor;mouse model;Mus;Mutation;nanomaterials;nanomedicine;nanoparticle;Neural Retina;new technology;next generation;Night Blindness;nonhuman primate;Nonsense Codon;Nonsense Mutation;novel;nucleic acid-based therapeutics;Nucleotides;Ophthalmologist;Organoids;Pathogenesis;Patients;Pharmaceutical Preparations;pharmacologic;Photoreceptors;Phototransduction;Physiology;Point Mutation;polypeptide;Post-Translational Protein Processing;pre-clinical;pre-clinical therapy;preclinical safety;premature;Production;Protein Biosynthesis;Protein translocation;Protein Truncation;Proteins;Proteomics;repaired;Research;Research Personnel;Resources;Retina;Retinal Diseases;Retinal Photoreceptors;retinal progenitor cell;Ribosomes;RNA delivery;RNA-targeting therapy;safety assessment;safety testing;Scientist;sight restoration;Silicon Dioxide;Site;small molecule;small molecule therapeutics;stem cell biology;Structure;Structure of retinal pigment epithelium;System;targeted delivery;Technology;Terminator Codon;Testing;Therapeutic;therapeutic gene;Therapeutic Intervention;therapeutic RNA;Tissues;Toxic effect;transcriptomics;Transfer RNA;Translations;TRPM1 gene;Universities;Viral;virtual;Vitelliform macular dystrophy

PROJECT_TITLE: Restoring Vision with High-Fidelity Nonsense Codon Correction


ADMINISTERING_IC: AI

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Digestive Diseases;Food Allergies;Nutrition;Pediatric;Prevention

ORG_CITY: BALTIMORE

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Peanut allergy is a growing public health concern that can lead to severe anaphylaxis and significant psychological burden. We are entering a new era of food allergy management sparked by the recent approval of the first drug for peanut allergy with many additional therapeutics in clinical trials, but the influence of these treatments on a patient's life is unknown. The goal of the proposed research is to evaluate the patient perceived benefit of PA therapy and to better understand patient decision-making with regard to discontinuation and treatment preferences.

PI_NAMEs: DANTZER, JENNIFER ANNE (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Accidents;Address;Adolescent;Affect;Age;age difference;age group;Allergens;Allergic Disease;Allergic Reaction;Allergy to peanuts;American;Anaphylaxis;Anxiety;Area;Benefits and Risks;career;career development;Caregivers;Caring;Child;Childhood;Clinical;Clinical Investigator;clinical practice;Clinical Trials;Complex;Data;Data Analyses;Databases;Decision Making;design;Development;Development Plans;Disease;Doctor of Philosophy;Economics;Emergency Situation;Ensure;Environment;Epidemiology;Exposure to;FDA approved;food avoidance;Food Hypersensitivity;Future;Goals;Grant;Health Benefit;Heterogeneity;human old age (65+);Hypersensitivity;Immunology;immunotherapy trials;Impairment;improved;Individual;Ingestion;insight;Interview;Knowledge;Knowledge acquisition;Label;Lead;Life;low socioeconomic status;Maintenance;Master of Science;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Methods;Mission;National Institute of Allergy and Infectious Disease;novel strategies;novel therapeutics;oral immunotherapy;Outcome;Outcomes Research;Parents;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;Physicians;Population;Practice Guidelines;preference;Prevalence;prevent;Prospective cohort;psychologic;psychosocial;Public Health;Quality of life;Questionnaires;Reaction;Reporting;Research;Research Personnel;Risk;Risk-Benefit Assessment;Scientist;skills;Statistical Data Interpretation;Surveys;targeted treatment;Techniques;Teenagers;Therapeutic;Time;tool;Training;translational scientist;treatment center;treatment choice;treatment effect;Uncertainty;Universities;Wood material;Work

PROJECT_TITLE: Patient-Centered Outcomes of the First Approved Peanut Allergy Treatment

STUDY_SECTION: AITC

STUDY_SECTION_NAME: Allergy, Immunology, and Transplantation Research Committee[AITC]


FUNDING_MECHANISM: NON-SBIR/STTR RPGS

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Orphan Drug;Pneumonia and Influenza;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases

ORG_CITY: ATLANTA

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative The Emory Vaccine and Treatment Evaluation Unit (VTEU) is well positioned to contribute to the mission of the Infectious Diseases Clinical Research Consortium (IDCRC) by conducting clinical protocols for evaluating vaccines, biologics, therapeutics, diagnostics including prognostic and predictive markers, and devices for the treatment and prevention of infectious diseases. The Emory VTEU benefits from the vibrant scientific environment present at Emory University with synergistic grants and thematic research centers, including the Emory Vaccine Center, as well as from the generous support of the institution. This highly supportive infrastructure enhances our ability to address NIAID priority areas including the need for broad scientific expertise, established clinical research infrastructure, flexible operational structure that has substantial surge capacity, access to unique and diverse study populations, state-of-the-art immunology and diagnostics laboratory, a record of accomplishment in designing and completing various complex clinical trials, a commitment to research mentoring, and dedication to training the next generation of investigators.

PI_NAMEs: DEL RIO, CARLOS ;ROUPHAEL, NADINE GEORGES (contact)

PROGRAM_OFFICER_NAME: SPARER, OLIVIA CAHN

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Adult;Anthrax disease;Antibiotic Resistance;Antimicrobial Resistance;Area;biodefense;Biological Products;career development;Categories;chikungunya;Childhood;Clinical;clinical data warehouse;Clinical Protocols;Clinical Research;clinical research site;Clinical Sciences;Clinical Trials;Clinical Trials Unit;Collaborations;Communicable Diseases;Communities;Complex;Consent;data management;data quality;Databases;Dedications;design;Devices;Diagnostic;disease diagnostic;Disease Outcome;Drug Kinetics;Ebola;Elderly;Emerging Communicable Diseases;Emerging infection;End Point Assay;Enrollment;Ensure;enteric pathogen;Environment;ethnic diversity;Ethnic Origin;Evaluation;Faculty;Female;flexibility;Funding;Generations;global health;Grant;Healthcare Systems;HIV;Human;Immunologic Tests;Immunologics;Immunology;improved outcome;Individual;Infection;Infectious disease threat;Influenza;Influenza A virus;Infrastructure;Institution;International;Laboratories;Laboratory Research;Lead;Leadership;Malaria;member;Mentors;Mission;Modeling;National Institute of Allergy and Infectious Disease;neglected tropical diseases;new epidemic;next generation;novel;Outpatients;pandemic influenza;pandemic response;Paper;Participant;pathogen;Patients;Pharmacy facility;Phase;Population Heterogeneity;Positioning Attribute;predictive marker;pregnant;prevent;Prevention;Procedures;Prognostic Marker;programs;protocol development;Protocols documentation;Publications;Publishing;quality assurance;Quality Control;Race;racial diversity;recruit;Research;Research Infrastructure;Research Personnel;Resources;respiratory pathogen;retention rate;Risk;Route;Science;Scientist;Sexually Transmitted Diseases;Site;Smallpox;Specimen Handling;square foot;Structure;study population;Systems Biology;Talents;Therapeutic;Training;Training and Education;Translational Research;trial design;Tuberculosis;Tularemia;Universities;vaccine delivery;vaccine evaluation;vaccine trial;Vaccines;vaccinology;ZIKA

PROJECT_TITLE: Vaccine and Treatment Evaluation Units


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Macular Degeneration;Neurodegenerative;Neurosciences;Nutrition

ORG_CITY: MORGANTOWN

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: WEST VIRGINIA UNIVERSITY

ORG_STATE: WV

PHR: NARRATIVE Retina has a unique metabolism that is altered in retinal degenerative diseases. Findings from our studies will provide the fundamental knowledge for what retina needs for its survival and function, and advance the understanding of the underlying causes of retinal diseases.

PI_NAMEs: DU, JIANHAI  (contact)

PROGRAM_OFFICER_NAME: NEUHOLD, LISA

PROJECT_TERMS: Age related macular degeneration;aging related;Aspartate;beta-Hydroxybutyrate;Biochemical;Cell Death;Cell Respiration;cell type;Cells;Choroid;Clinical;Codependence;Complex;conditional knockout;Data;Defect;Disease;Ecosystem;Energy Metabolism;Foundations;Functional disorder;glial activation;Glucose;glucose transport;Glutamates;Glutamine;Glycolysis;Glycolysis Inhibition;Goals;Health;high resolution imaging;Human body;Image;In Vitro;in vivo;Individual;Infusion procedures;inherited retinal degeneration;innovation;ketogenic diet;Ketone Bodies;Knock-out;Knockout Mice;Knowledge;late-onset retinal degeneration;Link;Macular degeneration;Mass Spectrum Analysis;Metabolic;Metabolism;metabolomics;Methodology;Mitochondria;mitochondrial dysfunction;Morphology;Muller's cell;Neuroglia;Neurons;Neurotransmitters;Nutrient;Optical Coherence Tomography;Outcomes Research;oxidation;Oxidative Phosphorylation;Phenotype;Photoreceptors;preservation;Pyruvate;pyruvate carrier;Recycling;Resolution;Retina;Retinal Degeneration;Retinal Diseases;retinal rods;Role;Structure of retinal pigment epithelium;Supporting Cell;Testing;Therapeutic;Tissues;Tracer;Transmission Electron Microscopy;Vascular blood supply;Vision;visual dysfunction

PROJECT_TITLE: Mitochondrial pyruvate transport in retinal health and disease

STUDY_SECTION: BVS

STUDY_SECTION_NAME: Biology of the Visual System Study Section[BVS]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cannabinoid Research;Depression;Endocannabinoid System Research;Mental Health;Neurosciences

ORG_CITY: PULLMAN

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: WASHINGTON STATE UNIVERSITY

ORG_STATE: WA

PHR: PROJECT NARRATIVE The societal and economic burden of stress-related mental disorders is currently at an all-time high. As such, there is specific urgency to better understand how the brain is changed under conditions of stress and how these adaptations contribute to the onset of cognitive deficits. In this proposal, we will identify how chronic stress alters the endogenous cannabinoid system in the lateral habenula, and determine whether stress- induced changes to this system are necessary to cause impairments in dopamine activity and behavioral flexibility.

PI_NAMEs: MCLAUGHLIN, RYAN JOSEPH (contact)

PROGRAM_OFFICER_NAME: BREEDEN, ANDREW LEE

PROJECT_TERMS: 2-arachidonylglycerol;Acute;Address;Animal Model;Area;Attention;Behavior;Behavioral;behavioral impairment;biological adaptation to stress;Brain;cannabinoid receptor;Cell Nucleus;Cells;Chronic;Chronic stress;Clinical;CNR1 gene;Cognitive deficits;combinatorial;Coping Skills;Data;Deep Brain Stimulation;depressed patient;Disease;Disease susceptibility;Dopamine;dopaminergic neuron;Economic Burden;Electrophysiology (science);Endocannabinoids;endogenous cannabinoid system;Exhibits;Exposure to;Feedback;Female;flexibility;Frequencies;Functional disorder;Future;Genetic;Goals;Habenula;Homeostasis;Hyperactivity;Impairment;in vivo;Individual;innovation;interdisciplinary approach;Knowledge;Label;Lateral;Life;Major Depressive Disorder;male;Mediating;Mental Depression;Mental disorders;Mental Health;mesolimbic system;Midbrain structure;Modeling;Neurons;neurophysiology;Outcome;Pathologic;Pathway interactions;Patients;pharmacologic;Phenotype;Population;Positioning Attribute;postsynaptic;pre-clinical;Rattus;Receptor Activation;Receptor Signaling;recruit;Research;Resistance;Risk Factors;Rodent;Rodent Model;Role;Signal Transduction;Site;Stress;Stress and Coping;Synapses;Synaptic plasticity;Synaptic Transmission;System;Testing;Therapeutic;Time;tool;transmission process;Ventral Tegmental Area;Viral;Work

PROJECT_TITLE: Endocannabinoid Modulation of the Habenular Stress Response

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology;Immunization;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Prevention;Vaccine Related

ORG_CITY: ANN ARBOR

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative The proposed research will develop statistical methods to detect and resolve unmeasured confounding bias by leveraging prior knowledge about known-null effects widely available but often underappreciated in healthcare data — thereby facilitating valid and reproducible research in vaccine effectiveness and safety studies.

PI_NAMEs: SHI, XU  (contact);TCHETGEN TCHETGEN, ERIC JOEL

PROGRAM_OFFICER_NAME: YU, GUOQIN

PROJECT_TERMS: Accounting;adverse event risk;Affect;Area;Benefits and Risks;Complex;curse of dimensionality;Data;Data Set;design;effectiveness evaluation;effectiveness study;Electronic Health Record;Ensure;Event;Failure;flexibility;Gene Expression Profiling;Health Policy;Healthcare;high dimensionality;improved;innovation;interest;Knowledge;Machine Learning;machine learning method;Methods;Modernization;Monitor;Nature;novel;Observational Study;Outcome;pathogen;Policy Analysis;Property;Public Health;public health priorities;Recording of previous events;Reproducibility;Research;Research Design;Research Personnel;Residual state;Risk;safety study;semiparametric;Statistical Methods;Techniques;Testing;theories;Time;Tissue-Specific Gene Expression;tool;Use Effectiveness;user friendly software;Vaccination;vaccine effectiveness;vaccine evaluation;vaccine safety;vaccine trial;Vaccines

PROJECT_TITLE: Accounting for Hidden Bias in Vaccine Studies: A Negative Control Framework

STUDY_SECTION: BMRD

STUDY_SECTION_NAME: Biostatistical Methods and Research Design Study Section[BMRD]


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: LA JOLLA

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: Project Narrative STARTneuro is a collaborative effort between UC San Diego Neurobiology faculty and the Academic Enrichment Programs Office along with articulation officers from San Diego area community colleges. The program aims to enhance diversity in neuroscience research through identifying, training, and mentoring transfer students from their matriculation at UC San Diego through the completion of their degrees. STARTneuro students will initially participate in an intensive 10-week summer research program followed by two years of course work, research training, mentoring, and skills development, ultimately translating to successful application to Ph.D. programs in neuroscience or a related field.

PI_NAMEs: BLOODGOOD, BRENDA L;JUAVINETT, ASHLEY LAUREN (contact)

PROGRAM_OFFICER_NAME: JONES, MICHELLE

PROJECT_TERMS: Academic support;Address;Area;Articulation;Brain;bridge program;career;Career Choice;cohort;Collaborations;college;community college;design;Doctor of Philosophy;doctoral student;Education;education pathway;Educational process of instructing;Educational workshop;experience;Faculty;Family;First Generation College Students;Gene Expression;gene function;Generations;Goals;graduate school;Growth;improved;improved outcome;Instruction;interest;Internships;Knowledge;laboratory experience;Learning;Learning Module;matriculation;meetings;Mentors;Mentorship;Minority Groups;Neurobiology;Neurosciences;Neurosciences Research;Participant;Persons;Physiology;Population;Professional Organizations;programs;recruit;Research;Research Project Grants;Research Training;response;Scholarship;Services;skill acquisition;skills;STEM career;STEM field;student retention;Student Selections;Students;success;summer program;summer research;symposium;System;Talents;Techniques;Time;Training;Training Programs;transfer student;Translating;undergraduate research;undergraduate research experience;undergraduate student;Underrepresented Minority;Underrepresented Populations;Universities;university student;Work

PROJECT_TITLE: Preparing Diverse Transfer Students for Research Careers in Neuroscience


NIH_SPENDING_CATS: Brain Disorders;Cardiovascular;Clinical Research;Data Science;Disability Research;Heart Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Precision Medicine;Prevention

ORG_CITY: STANFORD

ORG_DEPT: NEUROLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative Post-cardiac arrest injury affects the brain and other critical organs and is a major public health problem causing significant death and disability. This project will use novel data-driven approaches to collect high resolution monitoring data from patients in the critical care unit and will use that multi-parametric data to develop newly defined patient sub-groups with differing clinical trajectories and responses to therapies. This project will have a major impact on public health by allowing treatment of the right patient at the right time with the right therapy, thereby reducing disability and saving lives.

PI_NAMEs: ELMER, JONATHAN ;HIRSCH, KAREN G (contact)

PROGRAM_OFFICER_NAME: SCOTT, GRETCHEN CARLYLE

PROJECT_TERMS: Acute;Acute Disease;Address;advanced analytics;Affect;arm;Benchmarking;Biological Markers;biomarker signature;Brain;Brain Death;Brain Injuries;candidate marker;Cardiopulmonary;Cardiopulmonary Physiology;Caring;Cephalic;Cerebrum;Cessation of life;Clinical;clinical care;clinical predictors;Clinical Research;Critical Care;Critical Illness;Data;Data Analytics;Data Science;Data Set;design;Development;Diagnostic;disability;Disease;Dose;Electroencephalography;Electrophysiology (science);Foundations;Functional disorder;Goals;Head;Heart Arrest;Heterogeneity;Hospitalization;Hypoxic-Ischemic Brain Injury;Image;improved;improved outcome;Individual;individual patient;Injury;innovation;Intervention;Knowledge;Lead;Learning;Life;long term recovery;Measurable;Measures;Methods;Modality;Molecular;Monitor;Morbidity - disease rate;mortality;multidisciplinary;multimodal data;multimodality;natural hypothermia;Nervous System Trauma;Neurologic;Neurologic Examination;neuroprotection;Neurosciences;novel;novel marker;Organ;Organ failure;Outcome;outcome prediction;patient subsets;Patient-Focused Outcomes;Patients;Pattern;Performance;personalized care;personalized medicine;Physiological;Physiology;Positioning Attribute;precision medicine;Prediction of Response to Therapy;predictive marker;predictive modeling;prognostic;prognostic value;prospective;Public Health;Pupil light reflex;radiological imaging;Random Allocation;random forest;Recovery;Recovery of Function;Research;Research Personnel;Resolution;response;Rewarming;Role;Sampling;Severities;Severity of illness;Source;Specificity;Standardization;Subgroup;supervised learning;Survivors;Temperature;Testing;Time;Titrations;tool;Translating;treatment arm;treatment effect;treatment response;United States National Institutes of Health;unsupervised learning;Validation;Work

PROJECT_TITLE: PREcision Care In Cardiac ArrEst - ICECAP (PRECICECAP)


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular

ORG_CITY: DAVIS

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Project Narrative . The ability of the second messenger 3',5'-cyclic adenosine monophosphate (cAMP) to modulate vascular smooth muscle contractility, which controls the diameter of blood vessels, is well appreciated but poorly understood. Moreover, it is currently unknown how biological sex influences cAMP signaling in vascular smooth muscle in health and disease. This proposal addresses these fundamental knowledge gaps and fulfills relevant public health goals and NIH missions by generating fundamental basic knowledge that could help identify and develop novel treatment strategies to address vascular complications associated with diabetes and hypertension.

PI_NAMEs: NAVEDO, MANUEL F (contact)

PROGRAM_OFFICER_NAME: CATANIA, SELEN MURATOGLU

PROJECT_TERMS: Address;Adenylate Cyclase;Animal Model;Arteries;biological sex;Blood flow;blood flow measurement;Blood Vessels;Cardiovascular Diseases;Cells;clinically significant;Complex;Coupled;Cyclic AMP;Cyclic AMP-Dependent Protein Kinases;Data;Diabetes Mellitus;diabetic patient;Diameter;Disease;Enzymes;extracellular;Generations;Glucose;Health;health goals;Human;Hypertension;Image;Imaging Techniques;in silico;in vivo;innovation;insight;Knowledge;Link;male;Mediating;Membrane Microdomains;Mission;Modeling;Mus;Muscle Contraction;Muscle function;Myography;new therapeutic target;non-diabetic;novel;novel therapeutic intervention;Pathologic;Pathology;phosphoric diester hydrolase;Physiological;Premenopause;Production;Property;Proteins;Public Health;receptor;Regulation;Relaxation;Sarcoplasmic Reticulum;Second Messenger Systems;segregation;sensor;sex;Signal Transduction;Site;Stimulus;Testing;tool;treatment strategy;United States National Institutes of Health;Vascular Smooth Muscle;Vasodilation;Woman

STUDY_SECTION: IVPP

STUDY_SECTION_NAME: Integrative Vascular Physiology and Pathology Study Section[IVPP]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Precision Medicine;Prostate Cancer;Urologic Diseases

ORG_CITY: NEW YORK

ORG_DEPT: UROLOGY

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: Project Narrative  Metastatic prostate cancer is the second-leading cause of cancer-related deaths in men, ranks third in national cancer expenditures and represents significant morbidity to patients due to bone metastasis and side effects of treatment. This proposal will perform preclinical studies to identify previously unrecognized therapeutic vulnerabilities of prostate cancer bone metastasis and treatment-resistant tumors. These studies may ultimately result in novel treatments that can potentially improve survival and reduce morbidity of this lethal disease.

PI_NAMEs: ARRIAGA, JUAN MARTIN (contact)

PROGRAM_OFFICER_NAME: VAHEDI, SHAHROOZ

PROJECT_TERMS: Address;Advisory Committees;androgen deprivation therapy;androgen independent prostate cancer;Award;Biological Models;bone;Bromodomain;Cancer Etiology;career;career development;Cessation of life;Clinical;Clinical Trials;CRISPR screen;CRISPR/Cas technology;Data;Dependence;Development;Development Plans;Disease;Disease Outcome;Disseminated Malignant Neoplasm;drug development;effective therapy;Electroporation;Epigenetic Process;epigenomics;Evaluation;Expenditure;Fracture;Genes;Genetically Engineered Mouse;genome-wide;Genomics;Goals;Histone Acetylation;Human;improved;in vivo;in vivo Model;Indolent;inhibitor;innovation;interest;Knock-out;Knowledge;Lead;Localized Disease;Malignant neoplasm of prostate;Malignant Neoplasms;men;Metastatic Neoplasm to the Bone;Metastatic Prostate Cancer;Modeling;Molecular;Morbidity - disease rate;mortality;mouse genome;mouse model;Mutation;Neoplasm Metastasis;novel;novel strategies;novel therapeutic intervention;novel therapeutics;nuclease;Oncogenes;overexpression;Pain;Patient Care;Patients;Penetrance;Pharmaceutical Preparations;Phenotype;Physiological;pre-clinical;precision medicine;preclinical study;Prostate;prostate cancer metastasis;prostate cancer model;prostate cancer progression;Prostate Cancer therapy;Prostatic Neoplasms;Reader;Research;Resistance;Signal Transduction;Signaling Molecule;Site;small molecule;small molecule inhibitor;somatic cell gene editing;spinal cord compression;standard of care;Survival Rate;targeted agent;targeted treatment;Techniques;Therapeutic;therapeutic development;therapy resistant;tool;Training;transcription factor;treatment as usual;treatment response;Treatment Side Effects;treatment strategy;Tropism;tumor;tumor microenvironment;Universities;Whole Organism

PROJECT_TITLE: Identification of therapeutic vulnerabilities in prostate cancer bone metastasis

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


NIH_SPENDING_CATS: Biotechnology;Neurosciences;Opioids;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: In this proposal, we have identified a novel axon-derived peptide class, namely dynorphins that promotes OL differentiation and myelination, and hypothesize that release of dynorphins along axons occurs in an activity dependent manner. Our preliminary data place us in a unique position to determine whether dynorphin represents an axonal cue to control the spatial and temporal dynamics of OL differentiation and myelination. We believe that these findings should impart valuable insight in providing a framework for identifying additional neuropeptides and transmitters that may influence oligodendroglial lineage cells, as well as for profiling inhibitory and inductive cues for myelination.

PI_NAMEs: CHAN, JONAH R (contact)

PROGRAM_OFFICER_NAME: TYLER, WILLIAM A

PROJECT_TERMS: acute stress;Address;Adult;Affect;antagonist;Axon;Behavior;Binding;Biology;biophysical properties;Cell Differentiation process;Cell Lineage;Cell Proliferation;Cells;Characteristics;Coculture Techniques;Complex;Corpus striatum structure;Cre driver;CSPG4 gene;Cues;Data;Dense Core Vesicle;designer receptors exclusively activated by designer drugs;Development;Diameter;Dose;Dynorphins;extracellular;Fiber;FRAP1 gene;G-Protein-Coupled Receptors;Gene Expression;Gene Expression Profiling;Generations;Genetic Recombination;high throughput screening;Histologic;In Vitro;insight;Interneurons;kappa opioid receptors;Knockout Mice;Label;MAP Kinase Gene;MAPK3 gene;Mediating;Mediator;Membrane;Minor;Molecular;Mus;Muscarinics;Myelin;myelination;neuronal cell body;neuronal circuitry;Neurons;Neuropeptides;neurotransmission;novel;oligodendrocyte progenitor;Oligodendroglia;Opioid agonist;p38 Mitogen Activated Protein Kinase;Pathway interactions;Pattern;Peptides;Phenocopy;Population;Positioning Attribute;postnatal;precursor cell;Process;Qualifying;Receptor Activation;Reporter;response;Selective Estrogen Receptor Modulators;Signal Pathway;Signal Transduction;small molecule;Stress;Swimming;tau Proteins;Visualization

PROJECT_TITLE: Neuropeptides as axonal determinants for oligodendrocyte differentiation and myelination


NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: AUSTIN

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

ORG_STATE: TX

PHR: Narrative Temperature and light induce epigenetic changes that trigger developmental transitions that involve chromatin modifications, long noncoding RNAs (lncRNAs), and changes in three-dimensional structure of chromatin. Rich knowledge on protein components as well as lncRNA components makes Arabidopsis a useful model for study of the epigenetic mechanism of gene regulation with relevance to gene regulation in all eukaryotes including yeast, Drosophila, and human. Furthermore, the environmentally induced nature of developmental responses (i.e. vernalization response and light response) provides a unique opportunity to study the effect of environment on the epigenetic regulation of gene expression in developmental programs.

PI_NAMEs: SUNG, SIBUM  (contact)

PROGRAM_OFFICER_NAME: CHOW, CHI-WING

PROJECT_TERMS: 26S proteasome;3-Dimensional;Acceleration;Address;Affect;Animals;Arabidopsis;Architecture;bioinformatics pipeline;Biological;Biological Models;Cell Nucleus;Chromatin;Chromatin Loop;chromatin modification;chromatin protein;Chromatin Structure;Complex;Cues;Data;design;Development;Drosophila genus;Environment;Epigenetic Process;epigenetic regulation;Eukaryota;Eukaryotic Cell;Event;Experimental Models;experimental study;Flowers;Gene Expression;Gene Expression Regulation;Genes;genetic regulatory protein;Genetic Transcription;Genome;genome-wide;Goals;high throughput analysis;histone modification;HMGN Proteins;Human;in vivo;Knowledge;Light;Mediating;Modeling;Molecular Conformation;Nature;Nucleosomes;Organism;Phenotype;Photoreceptors;phyB phytochrome;Plants;Play;Polycomb;predictive modeling;Process;programs;protein degradation;Proteins;Regulation;Repression;Research;response;Role;Signal Transduction;SPT6 Protein;Stimulus;Structure;Study models;System;Temperature;Testing;three dimensional structure;Ubiquitin;Untranslated RNA;Work;Yeasts

PROJECT_TITLE: Coordinated regulation of developmental transition by protein and long noncoding RNA components

STUDY_SECTION_NAME: Development - 1 Study Section[DEV1]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Emerging Infectious Diseases;Health Services;Immunization;Infectious Diseases;Influenza;Lung;Malaria;Malaria Vaccine;Orphan Drug;Pneumonia and Influenza;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases

ORG_CITY: Oakland

ORG_NAME: KAISER FOUNDATION RESEARCH INSTITUTE

PHR: Narrative Infectious diseases continue to pose a significant threat to human health, with many types of infections having far-reaching, global consequences. The Kaiser Washington Vaccine and Treatment Unit will work with other centers and the National Institutes of Health to conduct clinical trials and research studies of ways to prevent and treat infectious diseases such as influenza, malaria, and tuberculosis, by using vaccines or anti-infective agents, or by finding better ways to identify these infections. We will also maintain the ability to respond quickly to emerging infectious disease threats, such as an influenza pandemic, to protect public health.

PI_NAMEs: JACKSON, LISA A (contact)

PROGRAM_OFFICER_NAME: LARKIN, BRENDA D

PROJECT_TERMS: Acute respiratory infection;Address;Adjuvant;Adult;Adult women;Age;Anti-Infective Agents;Area;Avian Influenza;Biological Products;Biomedical Research;Cancer Research Network;Caring;Child;China;Clinical Research;clinical research site;Clinical Trials;Collaborations;Communicable Diseases;Communities;Computerized Medical Record;Conduct Clinical Trials;Contracts;Data;design;Development;Devices;Diagnostic;Doctor of Philosophy;Drug Kinetics;Elements;Emerging Communicable Diseases;Enrollment;Evaluation;experience;experimental study;Fostering;Group Structure;Health;health plan;Health Policy;high risk population;HIV Vaccine Trials Network;Human;Immunologics;Immunology;Infection;Infectious disease threat;Infectious Diseases Research;Influenza;Influenza A Virus, H1N1 Subtype;Influenza A Virus, H7N9 Subtype;influenza infection;influenza outbreak;Influenza prevention;influenza virus vaccine;Infrastructure;innovation;Integrated Health Care Systems;International;Kentucky;Laboratories;Leadership;Malaria;malaria infection;Malaria Vaccines;Medical center;member;Modeling;multidisciplinary;National Institute of Allergy and Infectious Disease;neglected tropical diseases;novel vaccines;older adult;operation;Outpatients;pandemic disease;pandemic influenza;Persons;Pharmacy facility;Pharmacy Schools;Phase;Pneumococcal Infections;Population;Population Heterogeneity;Pregnant Women;prevent;Preventive;Productivity;programs;Protocols documentation;Public Health;public health research;Research;Research Institute;Research Personnel;Research Priority;research study;Resources;Respiratory Tract Infections;response;Rhea;Schedule;Science;seasonal influenza;Site;Structure;supportive environment;Therapeutic;therapeutic candidate;training opportunity;Tuberculosis;U-Series Cooperative Agreements;United States National Institutes of Health;Universities;vaccine candidate;Vaccine Clinical Trial;vaccine development;vaccine effectiveness;vaccine trial;Vaccines;Washington;Work;working group

PROJECT_TITLE: Kaiser Washington Vaccine and Treatment Evaluation Unit


ORG_CITY: COLUMBIA

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

ORG_STATE: MO

PHR: The dedifferentiation of vascular smooth muscle cells (SMCs) into synthetic SMCs contributes substantively to many occlusive vascular diseases. However, the effective therapies targeting the SMC dedifferentiation are not well established. This proposal will uncover that cyclin dependent kinase 8 (CDK8) is a crucial mediator of occlusive vascular remodeling via metabolic control of the SMC dedifferentiation, thus facilitating the development of novel CDK8 targeting approaches to combat occlusive vascular disease.

PI_NAMEs: CUI, TAIXING  (contact)

PROJECT_TERMS: aerobic glycolysis;Amino Acids;Aorta;beta Actin;Binding;Bioinformatics;Blood Vessels;Bypass;Carotid Arteries;cell dedifferentiation;Cell Separation;ChIP-seq;clinically relevant;combat;Cues;Cyclin-Dependent Kinases;Data;Development;Disease;DNA;effective therapy;Exhibits;Failure;fatty acid oxidation;Genetic Transcription;Glass;Glucose;Hyperplasia;In Vitro;in vivo;inhibitor;innovation;insight;Investigation;Knockout Mice;Lesion;Ligation;Light;Link;LoxP-flanked allele;Maps;Mediating;Mediator;Metabolic;Metabolic Control;Metabolism;mevalonate;Molecular;mouse model;Mus;Muscle Cells;novel;Operative Surgical Procedures;Outcome;overexpression;oxidation;Pathogenesis;Pathway interactions;Phenotype;Pilot Projects;Process;Proliferating;Protein Geranylgeranylation;protein metabolism;Proto-Oncogene Proteins c-akt;Regulatory Element;Role;Scheme;Signal Pathway;Signal Transduction;small molecule inhibitor;Smooth Muscle Myocytes;Sterols;targeted treatment;Testing;therapeutically effective;transcriptome sequencing;Vascular Diseases;Vascular remodeling;Vascular Smooth Muscle;Vein graft

PROJECT_TITLE: Metabolic control of vascular smooth muscle cell plasticity


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Biomedical Imaging;Chronic Liver Disease and Cirrhosis;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Hepatitis;Liver Disease;Nutrition;Physical Activity;Prevention

ORG_CITY: HERSHEY

ORG_NAME: PENNSYLVANIA STATE UNIV HERSHEY MED CTR

ORG_STATE: PA

PHR: PROJECT NARRATIVE—There is no cure or effective drug therapy for nonalcoholic fatty liver disease (NAFLD), the leading cause of chronic liver disease worldwide. Consequently, exercise is an important part of NAFLD treatment, however, questions remain about how clinicians should prescribe exercise and why exercise is effective. To better understand this, patients with NAFLD will participate in an exercise program that will study how different exercise doses target abnormal metabolic pathways and lead to improvement in NAFLD activity.

PI_NAMEs: STINE, JONATHAN G (contact)

PROGRAM_OFFICER_NAME: OSGANIAN, VOULA

PROJECT_TERMS: 5'-AMP-activated protein kinase;Acute;Adherence;Adult;Animal Disease Models;Binding;career;career development;Chronic;chronic liver disease;Clinical;clinical care;Clinical Trials;Data;density;design;Development;Disease;Disease Progression;Dissociation;Dose;effective therapy;Enrollment;Ensure;Exercise;exercise intensity;exercise prescription;exercise program;exercise training;experience;Fatty acid glycerol esters;fatty acid oxidation;Frequencies;Future;Glycogen;Goals;Hepatic;Histologic;Histology;improved;innovation;Intervention Trial;lipid biosynthesis;Liver;liver biopsy;Liver diseases;Liver Fibrosis;Liver Glycogen;liver transplantation;Magnetic Resonance Imaging;Magnetic Resonance Spectroscopy;Measures;Mentors;Metabolic;Metabolic Pathway;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;Outcome;oxidation;Pathogenesis;Pathway interactions;Patients;Persons;Pharmacotherapy;Physical activity;Physicians;prevent;Program Development;programs;Protons;Public Health;Randomized;randomized, clinical trials;Recommendation;Research;response;Sample Size;Scientist;standard of care;Strenuous Exercise;Supervision;telehealth;Testing;Time;Tissues;Training;trial design;Variant;vigorous intensity

PROJECT_TITLE: Establishing the mechanism of benefit and dose of exercise required to improve liver histology in patients with nonalcoholic steatohepatitis

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics;Palliative Care;Radiation Oncology;Rare Diseases

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: Approximately 2,000 patients with thyroid cancer die each year in the U.S., and many more suffer from progressive, symptomatic disease. The limited number of advanced thyroid cancer patients has been a major obstacle to our understanding of the molecular mechanisms involved in disease progression, as well as to the development of effective therapies. Furthermore, even when the driving oncogenic insults are known and targeted inhibitors are available, cancers invariably develop resistance to them. In this application, we leverage the power of mouse genetics and in vivo disease modeling to characterize novel pathways that are critical for thyroid cancer development and to define novel paradigms for rationally designed combinatorial therapies. Successful completion of the proposed studies will help map novel signaling pathways and design effective therapies, providing benefit not only to advanced thyroid cancer patients, but also to those with other tumor types sharing the same genetic alterations.

PI_NAMEs: DI CRISTOFANO, ANTONIO  (contact)

PROGRAM_OFFICER_NAME: GHOSH-JANJIGIAN, SHARMISTHA

PROJECT_TERMS: Aggressive behavior;anaplastic thyroid cancer;Automobile Driving;BRAF gene;cancer diagnosis;Cancer Patient;Cell Culture Techniques;Cell Line;Cell Proliferation;Cell Survival;Cessation of life;Chemotherapy and/or radiation;Clinical;clinically relevant;combinatorial;Combined Modality Therapy;Complex;Critical Pathways;Cytotoxic Chemotherapy;Data;design;Development;Disease;disease model;Disease Progression;Drug Combinations;effective therapy;Emergency Situation;Endocrine;Epithelial Cells;Event;Feedback;Foundations;FRAP1 gene;Genetic;genetic approach;Genetically Engineered Mouse;Goals;In Vitro;in vivo;in vivo Model;Incidence;inhibitor;Knowledge;Malignant neoplasm of thyroid;Malignant Neoplasms;Maps;Mediating;MEKs;Molecular;Molecular Analysis;mouse genetics;mouse model;mutant;Mutate;Mutation;Neoplastic Cell Transformation;Neurofibromin 2;novel;Oncogenes;Oncogenic;Operative Surgical Procedures;overexpression;Palliative Care;Pathway interactions;patient population;patient subsets;Patients;Physiological;PIK3CG gene;Process;Prognosis;Protein Kinase;prototype;Radioactive Iodine;radioiodine therapy;rational design;Recurrence;Refractory;Resistance;Resistance development;resistance mechanism;response;Role;Sgk protein;Signal Pathway;Signal Transduction;targeted treatment;Testing;Therapeutic;therapeutic target;therapy resistant;Thyroid Gland;Time;TP53 gene;tumor;tumor growth;tumor progression;Unresectable;women's diagnosis

PROJECT_TITLE: Molecular analysis and therapeutic targeting of PI3K signaling in thyroid cancer


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences

ORG_DEPT: NEUROSCIENCES

ORG_NAME: NEW YORK UNIVERSITY

PHR: PROJECT NARRATIVE A major challenge in neuroscience is to understand how the brain acquires and stores information for long periods of time, and how these long-term memories become susceptible to neurological disorders and neurodegenerative diseases. A growing body of evidence suggests that growth factors (GFs), once considered to function mainly in development, also regulate synaptic plasticity and memory in the adult. We will use the powerful model system Aplysia, in which we have identified and characterized several GFs also found in higher animals including humans, to examine GF-mediated memory formation from a novel perspective, taking into account the temporal aspect of their activity as part of the cellular computation involved in long-term memory formation.

PI_NAMEs: CAREW, THOMAS J (contact)

PROGRAM_OFFICER_NAME: DRISCOLL, JAMIE DANIELLE

PROJECT_TERMS: Address;Adult;Afferent Neurons;analog;Animals;Aplysia;Attention;Binding;Biological;Biological Models;Brain;causal model;Cell Nucleus;Cells;Clinical;Cognition Disorders;Cytosol;Data;detector;Development;Disease;Event;Exhibits;experimental study;extracellular;Extracellular Protein;Extracellular Signal Regulated Kinases;Extracellular Space;Genetic Transcription;Goals;Growth Factor;Heart;Human;inhibitor;insight;Laboratories;Learning;Ligands;long term memory;man;marine;Mediating;MEKs;Memory;memory acquisition;Mental Health;Mitogen-Activated Protein Kinases;Molecular;Nature;Nervous System Disorder;Neurodegenerative Disorders;Neurosciences;novel;novel strategies;Nuclear;Pathway interactions;Pattern;permissiveness;Phosphorylation;Phosphotransferases;Physiologic pulse;Predisposition;Process;programs;Publishing;Regulation;Research;response;Role;Series;Serotonin;Shock;Signal Transduction;Site;Specificity;Stimulus;success;Synapses;Synaptic plasticity;System;Testing;Therapeutic Agents;therapeutically effective;Time;time interval;Training;training project;Transforming Growth Factor beta;Up-Regulation;virtual;Work

PROJECT_TITLE: Temporal Processing by Growth Factors in Memory Formation

STUDY_SECTION: LAM

STUDY_SECTION_NAME: Neurobiology of Learning and Memory Study Section[LAM]


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Cancer Genomics;Genetics;Human Genome;Immunotherapy;Precision Medicine;Women's Health Research

ORG_CITY: Nashville

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: Project Narrative: This proposal seeks to develop new combinations of treatment for patients with breast cancers. We will determine whether drugs that alter the tumor immune microenvironment can be used to make tumors that do not respond to immune checkpoint inhibitors responsive. If successful, these combined treatments will prolong the survival of breast cancer patients.

PI_NAMEs: RICHMOND, ANN  (contact);YAN, CHI

PROGRAM_OFFICER_NAME: VENKATACHALAM, SUNDARESAN

PROJECT_TERMS: AKT inhibition;angiogenesis;antagonist;anti-CTLA4;anti-PD-1;anti-tumor immune response;Autoimmunity;Blood specimen;Bone Marrow;Breast Cancer Model;Breast Cancer Patient;breast cancer survival;Breast Cancer therapy;cancer therapy;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Death;Cells;checkpoint therapy;chemokine;Chemotherapy and/or radiation;Clinical Research;Clinical Trials;Coculture Techniques;Combined Modality Therapy;CTLA4 gene;cytokine;Data;design;DNA sequencing;dosage;Dose;Dose Limiting;early phase clinical trial;effector T cell;efficacy evaluation;Endothelial Cells;Environment;ERBB2 gene;Exhibits;Fibroblasts;Flow Cytometry;Future;Genetic;genetic signature;Growth;Health;hormone receptor-positive;Human;humanized mouse;Immune;immune cell infiltrate;immune checkpoint;Immune checkpoint inhibitor;Immune response;Immunocompetent;immunogenic;immunogenic cell death;Immunohistochemistry;Immunologics;Immunotherapy;improved;Infiltration;Inflammation;inhibitor;inhibitor therapy;Leukocytes;Link;Lung;lymph nodes;Macrophage;Malignant Breast Neoplasm;Mammary Neoplasms;Mediating;Mediator;Medical;Melanoma;men;Metastatic breast cancer;Microtubules;mouse model;Mus;mutant;Mutate;Mutation;Myeloid-derived suppressor cells;Neoplasm Metastasis;neoplastic cell;Oncogenes;Organoids;Paclitaxel;Pathway Analysis;Pathway interactions;patient derived xenograft model;Patients;Pharmaceutical Preparations;Phase;Phenotype;phosphatidylinositol 3-kinase gamma;PIK3CG gene;Poison;predicting response;Prediction of Response to Therapy;predictive signature;Prognosis;programmed cell death ligand 1;programmed cell death protein 1;Progression-Free Survivals;Property;Protein Analysis;Proteins;Proto-Oncogene Proteins c-akt;Publishing;Regulatory T-Lymphocyte;Relapse;response;Role;Schedule;standard of care;Stromal Cells;Stromal Neoplasm;Survival Rate;synergism;targeted treatment;Technology;Testing;Therapeutic;Time;Tissues;Toxic effect;transcriptome;transcriptome sequencing;transcriptomics;Treatment Efficacy;treatment response;treatment strategy;triple-negative invasive breast carcinoma;tumor;tumor growth;Tumor-associated macrophages;tumor-immune system interactions;Tumor-Infiltrating Lymphocytes;Woman

PROJECT_TITLE: Optimizing Response to Immune Checkpoint Inhibitor Therapy for Breast Cancer: A Role for Inhibitors of the PI3K pathway

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 1 Study Section[MCT1]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Physical Activity;Prevention

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: PUBLIC HEALTH RELEVANCE Neurological impairment caused by aging, neurodegenerative diseases, or stroke is a major and ever increasing health burden. Exercise has been shown in animal models and clinical studies in humans to ameliorate these conditions. Understanding the underlying molecular mechanisms of these neuroprotective effects of exercise harbors the potential to develop innovative therapeutic approaches for treating these disorders.

PI_NAMEs: WRANN, CHRISTIANE D. (contact)

PROGRAM_OFFICER_NAME: LAVAUTE, TIMOTHY M

PROJECT_TERMS: Acceleration;Address;Adult;adult neurogenesis;Affect;Aging;Alzheimer's Disease;Alzheimer's disease model;Animal Model;behavior test;Brain;Cells;Clinical Research;cognitive benefits;cognitive change;cognitive enhancement;cognitive function;Communication;Data;dentate gyrus;Development;discrimination task;Disease;Drug Targeting;effective therapy;endurance exercise;Exercise;experimental study;Fibronectins;Genetic;Genetic Models;Genetic Transcription;Goals;Health;Hippocampus;Hormones;Human;human model;human subject;Impaired cognition;Impairment;improved;in vivo;Injections;innovation;insight;Knock-out;Knockout Mice;Knowledge;Learning;Length;Link;loss of function;Mediating;Mediator;Memory;middle age;Molecular;Morphology;mouse model;Muscle;Muscle function;Neurodegenerative Disorders;neurogenesis;Neurologic;Neurons;neuroprotection;newborn neuron;novel;old mice;Organ;Peripheral;Physical activity;pre-clinical;programs;Proteins;public health relevance;Publishing;Rejuvenation;Running;Serum;Skeletal Muscle;Source;Stroke;Study models;success;Tail;Techniques;Testing;Therapeutic;therapeutic candidate;Tissue Model;transcriptome;Transgenic Mice;Veins;Work

PROJECT_TITLE: FNDC5/irisin as a Molecular Mediator of Exercise Benefits in Cognitive Function

STUDY_SECTION: LMDN

STUDY_SECTION_NAME: Learning, Memory and Decision Neuroscience Study Section[LMDN]


NIH_SPENDING_CATS: Cancer;Childhood Leukemia;Genetics;Hematology;Lymphatic Research;Lymphoma;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

PHR: NARRATIVE Recent work from our groups has demonstrated that PRDM15, a member of the PRDM family of transcription regulators, is essential in early embryogenesis, but dispensable for adult homeostasis. Given the upregulation of PRDM15 expression in different types of human B cell lymphomas, here we propose to investigate the function of PRDM15 in both normal hematopoiesis, under conditions of B cell activation, and during lymphomagenesis. This study aims at understanding the mechanism of PRDM15-driven metabolic rewiring and explore future opportunities for therapeutic intervention in PRDM15 overexpressing B cell lymphomas.

PI_NAMEs: GUCCIONE, ERNESTO  (contact)

PROGRAM_OFFICER_NAME: JHAPPAN, CHAMELLI

PROJECT_TERMS: Acceleration;Accounting;Adult;Adverse effects;Antigens;Antisense Oligonucleotides;B cell differentiation;B lymphoid malignancy;B-Cell Activation;B-Cell Acute Lymphoblastic Leukemia;B-Cell Antigen Receptor;B-Cell Lymphomas;B-Cell NonHodgkins Lymphoma;B-Lymphocytes;BCL2 gene;Binding;Bone Marrow;Burkitt Lymphoma;Cells;Cellular biology;Chromatin;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Data;Dependence;Development;Diagnosis;Disease Progression;DNA Binding;Embryonic Development;Exposure to;Family;Family member;FRAP1 gene;Future;Genes;Genetic;Genetic Transcription;Glycolysis;Goals;Health;Hematologic Neoplasms;Hematopoiesis;Homeostasis;Human;IGF1R gene;immune activation;Immune signaling;in vivo;Incidence;INSR gene;large cell Diffuse non-Hodgkin's lymphoma;Lesion;Lymphocyte Activation;Lymphoma;Lymphomagenesis;Maintenance;Malignant Neoplasms;Mediating;member;Metabolic;Metabolic Pathway;Modeling;mTOR inhibition;multidisciplinary;Mus;new therapeutic target;novel;novel therapeutics;Oncogenic;overexpression;Pathway interactions;PAX5 gene;Pharmaceutical Preparations;Physiological;PI3K/AKT;premalignant;Process;programs;protein structure;Proteins;Receptor Activation;reconstitution;Resistance;response;Risk;Role;side effect;Signal Transduction;standard of care;Structure of germinal center of lymph node;targeted treatment;TCF3 gene;Therapeutic;Therapeutic Intervention;therapeutic target;transcription factor;tumor;tumor growth;tumor initiation;Tumor Promotion;Up-Regulation;Work;Zinc Fingers

PROJECT_TITLE: DISSECTING THE ROLE OF PRDM15 IN NORMAL HEMATOPOIESIS AND B-CELL MALIGNANCIES

STUDY_SECTION: MONC

STUDY_SECTION_NAME: Molecular Oncogenesis Study Section[MONC]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Immunization;Immunotherapy;Nanotechnology;Skin Cancer;Vaccine Related

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: PROJECT NARRATIVE Harnessing the immune system to eradicate malignant cells is a powerful novel approach to develop cancer therapy. However, cancer immunotherapy for many types of solid tumors is still lacking. Our goal here is to identify multiple neoantigens from each cancer patient since it is not known which neoantigen is more immunogenic than others. These neoantigens can be identified from solid cancer including melanoma and used as therapeutic targets for immunotherapy using novel vaccine strategies. To summarize, the positive outcome of our proposed studies will shift the paradigm by paving the way for the development of novel immunotherapies to eradicate solid cancer including melanoma.

PI_NAMEs: WANG, RONGFU  (contact)

PROGRAM_OFFICER_NAME: SINGH, ANJU

PROJECT_TERMS: anti-CTLA4;anti-melanoma immunity;anti-PD-1;anti-PD-L1 antibodies;Antibodies;Antibody Therapy;Antigen Targeting;Antigen-Presenting Cells;antigen-specific T cells;Antigens;Antitumor Response;Bioinformatics;cancer cell;cancer immunotherapy;Cancer Patient;cancer therapy;cancer type;Carcinoma;CD19 gene;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cell Line;Cellular Immunity;checkpoint modulation;chimeric antigen receptor;Chimeric Proteins;Clinical;Clinical Research;Clinical Trials;Computer Assisted;cytotoxic;cytotoxicity;Data;Dendritic Cell Vaccine;Development;Disseminated Malignant Neoplasm;Engineering;exome sequencing;FDA approved;Genetic;genome-wide;Goals;Hematopoietic Neoplasms;immune checkpoint blockade;Immune system;Immunity;immunogenic;Immunotherapeutic agent;Immunotherapy;improved;invariant chain;ipilimumab;knock-down;Laboratories;Malignant Neoplasms;Mediating;Melanoma;Melanoma Cell;MHC Class II Genes;Mutate;Mutation;nanoparticle;Nanotechnology;neoantigens;neoplastic cell;next generation sequencing;novel;novel strategies;novel vaccines;Outcome;Patients;Peptides;personalized immunotherapy;Pharmaceutical Preparations;Play;prediction algorithm;programmed cell death protein 1;Reagent;response;Role;Sampling;screening;self assembly;Solid;Solid Neoplasm;System;T-Cell Receptor;T-Lymphocyte;Technology;Testing;Therapeutic;therapeutic target;trafficking;Transgenic Mice;tumor;Tumor Antigens;tumor growth;Tumor Immunity;vaccine strategy;Vaccines

PROJECT_TITLE: CD4+ T cells and neoantigens in melanoma immunotherapy.

STUDY_SECTION: TTT

STUDY_SECTION_NAME: Transplantation, Tolerance, and Tumor Immunology Study Section[TTT]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

ORG_CITY: CAMBRIDGE

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

PHR: PROJECT NARRATIVE Ribonucleotide reductase (RNR) is an essential enzyme and is responsible for the reduction of ribonucelotides into deoxyribonucleotides for use in DNA biosynthesis. For this reason, an understanding of the chemical and structural mechanisms of RNR catalysis are crucial for informing our efforts to develop novel anti-cancer and anti-pathogenic drugs. A recent breakthrough in elucidating the structure of the active state of the E. coli class Ia RNR has enabled us to revisit many of the remaining questions regarding the catalytic mechanism of this prototypical RNR. Here, we propose to use this unprecedented structural snapshot to inform our efforts to answer several critical outstanding questions regarding the proton-coupled electron transfer pathway and the re-reduction mechanism of RNR via site-directed mutagenesis studies and using structural techniques such as crystallography and cryogenic electron microscopy.

PI_NAMEs: WESTMORELAND, DANA  (contact)

PROGRAM_OFFICER_NAME: SIMONOVIC, MILJAN

PROJECT_TITLE: Structure function investigations of radical transfer and disulfide exchange in a class Ia ribonucleotide reductase


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Services;Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Telehealth

ORG_CITY: SEATTLE

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: Project Narrative: This proposal is a partnership between Mental Health America (MHA), a nonprofit mental health advocacy and resource organization, Talkspace (TS), a for-profit, online digital psychotherapy organization, and the University of Washington’s Schools of Medicine and Computer Science Engineering (UW). The purpose of this partnership is to create a digital mental health research platform leveraging MHA and TS’s marketing platforms and consumer base to describe the characteristics of optimal engagement with digital mental health treatment, and to identify effective, personalized methods to enhance motivation to engage in digital mental health treatment in order to improve mental health outcomes. These aims will be met by identifying and following at least 100,000 MHA and TS consumers over the next 4 years, apply machine learning approaches to characterizing client engagement subtypes, and apply micro-randomized trials to study the effectiveness of motivational enhancement strategies and response to digital mental health treatment.

PI_NAMEs: ALTHOFF, TIM  (contact)

PROGRAM_OFFICER_NAME: DAVIS, BESHAUN JAMAAL

PROJECT_TERMS: 10 year old;Address;Advocacy;Age;base;Behavior;behavior change;behavior prediction;Caring;Categories;Characteristics;Classification;Client;Clinical;Code;Communication;comorbidity;computer science;coping;Data;demographics;design;Detection;Diagnosis;digital;digital mental health;Disease;Dose;Dropout;Effectiveness;effectiveness study;effectiveness testing;Engineering;Enrollment;Ethnic Origin;expectation;falls;Focus Groups;Frequencies;Future;Gender;Goals;Health;Health behavior change;health goals;Hour;improved;Income;Informatics;Intake;Investments;Language;Learning;Length;Longevity;Machine Learning;machine learning method;Maintenance;Marketing;Measures;Mediating;medical schools;Mental Health;Mental Health Services;Methods;Modeling;Motivation;Movement;Natural Language Processing;Outcome;Outcome Measure;outcome prediction;Participant;Patient Recruitments;Patient Self-Report;Pattern;Personal Satisfaction;personalized strategies;Population;predictive marker;prevent;Process;programs;prospective;Provider;psychoeducation;Psychotherapy;Randomized;randomized trial;randomized, clinical trials;Recovery;Research;Resources;response;Risk;Sampling;satisfaction;screening;Self Efficacy;self help;Sequential Multiple Assignment Randomized Trial;Series;Services;Severities;skills;success;supervised learning;Surveys;Symptoms;Techniques;Technology;Testing;Text;theories;Time;tool;trial design;Universities;user centered design;Visit;Volition;Washington;web app;web page;Well in self;Work

PROJECT_TITLE: Enhancing Engagement with Digital Mental Health Care


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;HIV/AIDS;Immunization;Infectious Diseases;Lung;Orphan Drug;Pediatric;Pediatric - AIDS;Prevention;Rare Diseases;Tuberculosis;Vaccine Related;Women's Health Research

ORG_CITY: CORAL GABLES

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: Narrative Almost particularly 80% infection research women we will one third of the world's is infected with Mycobacterium tuberculosis which is deadly for infants and young children with 240,000 deaths from active TB in 2015, almost of which were in children under 5 year of age. Infants have a higher risk of acquiring a new TB and progressing from latent to active disease despite administration of the BCG vaccine. This is focused on understanding how maternal immunity or latent TB infection in HIV+ pregnant influences immunity for TB and BCG vaccination in their HIV uninfected infants. For this work, utilize maternal-infant PBMC and plasma of samples from a completed clinical trial (P1078). population , This research has important implications for improving our understanding of immunity to TB in infants.

PI_NAMEs: PAHWA, SAVITA  (contact)

PROGRAM_OFFICER_NAME: CHIOU, CHEN-CHIA CHRISTINE C

PROJECT_TERMS: Affect;Age;Age Years;antenatal;Antibodies;Antigens;Area;Bacille Calmette-Guerin vaccination;BCG Live;BCG Vaccine;Binding;Biological Assay;Biological Markers;biophysical techniques;Birth;Blood;Breast Feeding;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cell Maturation;Cells;Cessation of life;Characteristics;Child;Childhood;Clinical;Clinical Trials;Collaborations;Color;Country;cytokine;Cytometry;Data;Data Analyses;data exchange;Development;Diagnosis;Diagnostic tests;Disease;Enrollment;Exercise;Flow Cytometry;Gene Expression Profile;Genes;Gold;Helper-Inducer T-Lymphocyte;high risk;HIV;HIV Infections;HIV-exposed uninfected infant;IL17 gene;Immune;Immune checkpoint inhibitor;Immune response;Immunity;Immunoglobulin A;Immunoglobulin G;Immunoglobulin M;Immunologic Memory;Immunologic Tests;Immunologics;Immunology;improved;in utero;Incidence;indexing;Individual;Infant;Infant Development;Infant Mortality;Infection;Intake;Interferons;Interleukin-2;interleukin-21;interleukin-22;International Maternal Pediatric Adolescent AIDS Clinical Trials;isoniazid;Laboratories;Life;Literature;Longevity;Maternally-Acquired Immunity;Measures;Mediating;Memory;memory CD4 T lymphocyte;Meningeal Tuberculosis;Miliary Tuberculosis;monocyte;mortality risk;Mothers;mycobacterial;Mycobacterium bovis;Mycobacterium tuberculosis;Mycobacterium tuberculosis antigens;new technology;Newborn Infant;Participant;Peripheral;Peripheral Blood Mononuclear Cell;Persons;Pharmaceutical Preparations;Phenotype;Plasma;Population;Postpartum Period;Pregnancy;pregnant;Pregnant Women;Prevalence;prevent;Prevention therapy;Preventive therapy;programmed cell death protein 1;progression risk;Proliferating;protein purification;Protocols documentation;Pulmonary Tuberculosis;reactivation from latency;Regulatory T-Lymphocyte;repository;Research;Research Personnel;response;Risk;Risk Factors;Role;safety assessment;safety testing;Sampling;Serology;single-cell RNA sequencing;Sorting;System;T-Lymphocyte Subsets;Testing;Time;TNF gene;TNFSF5 gene;Transcript;transcriptome;transcriptomics;Tube;Tuberculosis;tuberculosis immunity;Tuberculosis Vaccines;vaccination against tuberculosis;vaccine response;vaccine strategy;Vaccines;Woman;Work

PROJECT_TITLE: Immune correlates of LTBI in HIV-exposed infants


ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: Project Narrative Biochemical modification of ribonucleic acid (RNA) is a new layer of molecular control in gene expression; however, whether RNA chemical modification contributes to vascular health and disease is virtually unknown. Our studies investigate a novel role of RNA chemical modification in regulating endothelial functions under blood flow. We also plan to test a nanoparticle-based therapy in modulating RNA chemical modification to treat vascular disease.

PI_NAMEs: HE, CHUAN  (contact)

PROGRAM_OFFICER_NAME: CHEN, JUE

PROJECT_TERMS: Acceleration;Address;Artificial nanoparticles;atherogenesis;Atherosclerosis;base;Biochemical;Biological Process;Blood flow;Blood Vessels;Cardiac Myocytes;cell type;Cells;Chemicals;cohort;Data;Development;Disease;Endothelium;epitranscriptome;epitranscriptomics;Functional disorder;Gene Expression;Goals;Health;hemodynamics;Human;In Vitro;in vivo;innovation;Knockout Mice;Knowledge;Link;Malignant Neoplasms;Maps;mechanotransduction;Mediating;Messenger RNA;Methylation;methylome;Methyltransferase;Modification;Molecular;mRNA Stability;multidisciplinary;Mus;nanomedicine;nanoparticle;novel;novel therapeutic intervention;Pathway interactions;Proliferating;Regulation;Resolution;restoration;Risk Factors;RNA;Role;Site;stem cell differentiation;Technology;Testing;Therapeutic;therapeutic effectiveness;therapeutic evaluation;transcriptome;Vascular Cell Adhesion Molecule-1;Vascular Diseases;Vascular Endothelium;virtual

PROJECT_TITLE: Mechanosensitive M7G epitranscriptome in endothelial health and disease

STUDY_SECTION: AVI

STUDY_SECTION_NAME: Atherosclerosis and Vascular Inflammation Study Section[AVI]


NIH_SPENDING_CATS: Digestive Diseases;Liver Disease;Orphan Drug;Rare Diseases

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

PHR: PROJECT NARRATIVE: Marked alterations of mitochondria have been observed in liver cells of human α1-antitrypsin deficiency (ATD) patients and the PiZ mouse model of ATD, leading to speculation that mitochondrial dysfunction is at least part of the pathogenesis of severe ATD liver disease. Based on that consideration and our new preliminary data, we now believe that mitochondrial impairment is a key part of the pathobiology of ATD liver disease in two ways, impaired liver cell energy metabolism and reduced autophagic response, and, therein, that mitochondrial function is a very appealing target for potential therapeutic interventions. In this grant we propose to study the effects of ATZ accumulation on mitochondrial function to better understand the mechanism by which liver is damaged and to investigate whether mitochondrial function can be targeted for therapy.

PI_NAMEs: PERLMUTTER, DAVID H;RUDNICK, DAVID A (contact)

PROGRAM_OFFICER_NAME: LOH, KATRINA SHUEH WEN

PROJECT_TERMS: Adenine;Adult;alpha 1-Antitrypsin;alpha 1-Antitrypsin Deficiency;Anabolism;Animal Model;Autophagocytosis;Biogenesis;Breeding;Cell Line;Cell model;Cell Physiology;Cells;Child;clinical effect;Clinical Trials;Data;Degradation Pathway;design;Endoplasmic Reticulum;Energy Metabolism;Enzymes;Genes;Genetic;Glycoproteins;Goals;Grant;Hela Cells;Hepatic;Hepatocyte;Homozygote;Human;Impairment;Induced Hepatocytes;induced pluripotent stem cell;Insulin Receptor;Intervention;Knock-out;Laboratories;Learning;Liver;Liver diseases;Liver Fibrosis;liver injury;liver transplantation;Mitochondria;mitochondrial dysfunction;Modeling;Molecular;mouse model;Mus;Nematoda;new therapeutic target;Niacinamide;Nicotinamide Mononucleotide;Organelles;Outcome;overexpression;Oxidative Phosphorylation;Pathogenesis;Pathway interactions;Patients;Pharmaceutical Preparations;pharmacologic;Play;Point Mutation;Polymers;PPAR gamma;Preclinical Testing;Process;response;Role;Series;Specificity;Subgroup;Supplementation;targeted treatment;Testing;Therapeutic;Therapeutic Intervention;Trypsin;Up-Regulation;Variant;Work

PROJECT_TITLE: Novel therapies that target mitochondrial dysfunction for treatment of a1-antitrypsin deficiency liver disease

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Rare Diseases

ORG_CITY: WORCESTER

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: The 2013–2016 Ebola virus (EBOV) disease (EVD) epidemic was orders of magnitude larger than any other EVD outbreak. A mutation in the Ebola virus, GP- A82V, was found to dominate the outbreak and to increase infectivity in surrogate assays for the full virus. The experiments here will use genetic, biophysical, structural, and immunologic approaches to better understand the structure of the GP- A82V protein and the effect of the mutant on replication of full virus. These experiments are expected to help us to better understand how the Ebola virus replicates and, in turn, to develop new therapies that block this deadly virus.

PI_NAMEs: LUBAN, JEREMY  (contact)

PROGRAM_OFFICER_NAME: DUPUY, LESLEY CONRAD

PROJECT_TERMS: Animals;Antibodies;Antibody Response;atomic interactions;Biochemical;Biological Assay;Biophysics;Body Fluids;Cells;Complex;Computer Models;Cryoelectron Microscopy;Data;Dendritic Cells;Disease Outbreaks;Ebola Hemorrhagic Fever;Ebola virus;Engineering;Epidemic;Epidemiologic Factors;Equilibrium;experimental study;Fluorescence Resonance Energy Transfer;Funding;Genetic;genetic selection;Genome;Genomic Centers for Infectious Diseases;Genotype;Glean;glycoprotein structure;Glycoproteins;GPR85 gene;Human;humanized mouse;Immunologics;In Vitro;Individual;Infection;insight;Measurement;Modeling;Molecular Conformation;molecular dynamics;Monoclonal Antibodies;monomer;mouse model;Mucous Membrane;Mutagenesis;mutant;Mutation;National Institute of Allergy and Infectious Disease;Natural Killer Cells;neutralizing antibody;novel;novel therapeutics;NPC1 gene;Pathogenesis;Pathogenicity;Persons;Pharmaceutical Preparations;Property;Proteins;reconstitution;Reporting;Research Personnel;Resistance;Resources;reverse genetics;single molecule;Structure;System;Testing;tissue tropism;Tissues;tool;trait;transmission process;Universities;Variant;Viral;viral outbreak;Viral Pathogenesis;viral transmission;Virion;Virus;Virus Replication

PROJECT_TITLE: Insight into the Ebola virus glycoprotein fusion mechanism gleaned from the 2013-2016 epidemic GP-A82V variant

STUDY_SECTION: VIRA

STUDY_SECTION_NAME: Virology - A Study Section[VIRA]


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE We use visual shape information to evaluate objects in the world: to determine their identity, utility, familiarity and value. The project will advance our understanding of how visual shape information is processed in the cerebral cortex by investigating the mechanisms involved using innovative tools. Knowledge of these cortical mechanisms is essential for understanding normal visual function, and for developing therapeutic strategies for disorders of form vision such as visual agnosia.

PI_NAMEs: EL-SHAMAYLEH, YASMINE  (contact)

PROGRAM_OFFICER_NAME: FLANDERS, MARTHA C

PROJECT_TERMS: Area;area V1;area V2;area V4;Basic Science;Behavioral;Binding;Brain;cell type;Cerebral cortex;Complex;Disease;Dissection;Distant;Elements;excitatory neuron;experimental study;Familiarity;Foundations;Future;Genes;Goals;Human;inhibitory neuron;innovation;insight;Investigation;Knowledge;Measures;Mediating;Medicine;model organism;Molecular Profiling;Monitor;Monkeys;neural;neural circuit;Neural Pathways;Neurons;Neurosciences;object shape;optogenetics;Pathway interactions;preference;Primates;Process;Property;Regulatory Element;Research;response;retinotopic;Role;Sensory;Shapes;Signal Transduction;Source;Stimulus;System;Techniques;Testing;Therapeutic;tool;V4 neuron;Viral Vector;Vision;Visual;Visual Agnosias;Visual Cortex;visual processing;Work

PROJECT_TITLE: Cortical circuit mechanisms of visual shape processing

STUDY_SECTION: SPC

STUDY_SECTION_NAME: Mechanisms of Sensory, Perceptual, and Cognitive Processes Study Section[SPC]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

ORG_DEPT: GENETICS

PHR: Narrative: The Opportunities in Genomics Research (OGR) Program is designed to increase the number of students from underrepresented groups who pursue PhDs in genome science and related fields. OGR runs a summer undergraduate research program and an academic year post-baccalaureate research program. Through a suite of educational activities, these programs seek to train students to think critically and to write and speak effectively about their research project and science in general, and ultimately prepare them to gain acceptance to and succeed in top biomedical PhD programs nationwide.

PI_NAMEs: MITRA, ROBI D (contact);SKEATH, JAMES BENJAMIN

PROGRAM_OFFICER_NAME: JOSE, SHEETHAL

PROJECT_TERMS: Age;Area;Bachelor's Degree;Bioinformatics;Biomedical Research;Black American;career;Cementation;cohort;college;community building;Community Outreach;computer science;Critical Thinking;design;Development;disabled students;disadvantaged background;disadvantaged student;Doctor of Philosophy;doctoral student;Educational Activities;Educational workshop;Emotional;Ensure;Environment;Ethnic Origin;Event;Evolution;experience;Exposure to;Face;Funding;Genome;genome sciences;Genomics;Goals;graduate school;Grant;high school;High School Outreach;High School Student;Hispanic Americans;Human Genome Project;Interview;matriculation;Mentors;mid-career faculty;Mission;Modeling;Modernization;National Human Genome Research Institute;National Institute of General Medical Sciences;Native Americans;Outcome;outreach program;Population;Population Heterogeneity;Postbaccalaureate;programs;Race;Recording of previous events;Research;Research Project Grants;Resources;Running;Schools;Science;Scientist;senior faculty;STEM career;STEM field;student training;Students;success;summer program;Talents;Training;Training Programs;undergraduate research experience;undergraduate student;Underrepresented Minority;underrepresented minority student;Underrepresented Populations;Underrepresented Students;underserved area;United States;Universities;Washington;Writing

PROJECT_TITLE: Expanding Opportunities in Genomic Research for Underrepresented Students

STUDY_SECTION: GNOM

STUDY_SECTION_NAME: Genome Research Study Section[GNOM(O1)-G]


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Neurosciences;Orphan Drug;Radiation Oncology;Rare Diseases

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Narrative Glioblastoma (GBM) is universally lethal, virtually always recurring and we are investigating how one of the treatments for GBM, radiation, may ultimately contribute to this recurrence. We have found that radiation can cause tumor cells to become blood vessel cells. We will test the hypothesis that these newly formed vascular cells contribute to GBM progression and determine the mechanisms whereby this vascular reprogramming occurs in experimental animals and in human tumors.

PI_NAMEs: KORNBLUM, HARLEY IAN (contact)

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: Ablation;Angiogenesis Inhibitors;Animal Experiments;Animal Model;bevacizumab;Blood Vessels;Brain Neoplasms;candidate validation;Cells;Chemotherapy and/or radiation;Chromatin;chromatin modification;clinically relevant;Data;Endothelial Cells;Endothelium;EP300 gene;experimental study;Glioblastoma;Glioma;Goals;Growth;Histone Acetylation;histone acetyltransferase;histone modification;Human;Immune system;Immunocompetent;improved;In Vitro;in vivo;in vivo Model;loss of function;Mediating;migration;Modeling;Molecular;mouse model;neoplastic cell;novel therapeutics;Nutrient;Operative Surgical Procedures;Oxygen;Pericytes;Pharmaceutical Preparations;pharmacologic;Play;Primary Brain Neoplasms;Process;Production;Radiation;Radiation Dose Unit;radiation effect;Radiation therapy;Radiobiology;Recurrence;Recurrent tumor;Resistance;Role;Specific qualifier value;Supporting Cell;temozolomide;Testing;Therapeutic;therapeutic target;Therapeutically Targetable;therapy resistant;transcription factor;tumor;Tumor Biology;tumor growth;Tumor Promotion;Tumor-Derived;virtual;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Radiation-induced vascular reprogramming in glioblastoma

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


NIH_SPENDING_CATS: Cannabinoid Research;Endocannabinoid System Research;Eye Disease and Disorders of Vision;Neurosciences;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: A thorough understanding of the mechanisms that regulate the functions of retinal glial cells is crucially important to the development of new therapies to treat sight-threatening diseases of the eye. Retinal Müller glia are known to have the potential to become neurogenic progenitor cells. Identification and understanding the mechanisms that regulate the ability of Müller glia to reprogram into proliferating, neurogenic progenitors is key to developing new therapies to treat degenerative diseases. This proposal seeks to identify the important factors and pathways that control the ability of Müller glia to become proliferating progenitors and produce new functional neurons.

PI_NAMEs: FISCHER, ANDY J (contact)

PROGRAM_OFFICER_NAME: FORTRESS, ASHLEY

PROJECT_TERMS: Acute;Biological Models;Biology;Birds;Candidate Disease Gene;Cells;Chick;Chick model;cold blooded vertebrate;comparative;Data;Degenerative Disorder;Development;Disease;endocannabinoid signaling;Endocannabinoids;experimental study;Eye diseases;FABP5 gene;Failure;Fatty Acid-Binding Protein 1;fatty acid-binding proteins;Fishes;Gene Expression;Gene Expression Profile;gene network;genetic approach;Glaucoma;Goals;Growth Factor;human disease;in vivo;Investigation;Link;Macular degeneration;Mammals;Metabolism;Molecular;mouse model;Muller's cell;Mus;Nerve Regeneration;neural stimulation;neurogenesis;Neuroglia;neuron regeneration;Neurons;NF-kappa B;novel;novel therapeutics;Pathway interactions;pharmacologic;Phenotype;progenitor;programs;Proliferating;regeneration potential;regenerative;Reporter;Reporting;Research;Resolution;Retina;retinal damage;Retinal Diseases;retinal neuron;retinal progenitor cell;retinal regeneration;Retinitis Pigmentosa;Rodent Model;Role;sight restoration;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Source;stem cell proliferation;stem cell self renewal;stem cells;Stress;Testing;transcriptomics;Up-Regulation;Vertebrates;Vision

PROJECT_TITLE: Fatty acid binding-proteins and endocannabinoids in the retina; roles in glial reactivity and reprogramming of Muller glia into progenitor cells

STUDY_SECTION_NAME: Biology of the Visual System Study Section[BVS]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Autoimmune Disease;Complementary and Integrative Health;Dietary Supplements;Digestive Diseases;Inflammatory Bowel Disease;Nutrition

ORG_CITY: TUCSON

ORG_DEPT: NUTRITION

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: ER stress signals resolve cellular stress or lead to apoptosis. Functionally, ER stress has been linked disrupted intestinal homeostasis and inflammation. The studies in this proposal will establish sphingolipid enzymes and their lipid products as regulators of diet-induced ER stress and define their effects in intestinal inflammation.

PI_NAMEs: SNIDER, ASHLEY JONES (contact)

PROGRAM_OFFICER_NAME: SENGER, STEFANIA

PROJECT_TERMS: Apoptosis;arm;Autophagocytosis;Bioinformatics;Biology;Biopsy;Cellular Stress;Ceramides;Colitis;Complex;Corn Oil;Coupled;Data;Diet;dietary;Dietary Fatty Acid;dihydroceramide desaturase;Disease;Endoplasmic Reticulum Degradation Pathway;endoplasmic reticulum stress;Enzymes;Epithelial Cells;Event;Fatty acid glycerol esters;Fatty Acids;Fish Oils;Food;Functional disorder;Generations;Genes;Genetic Transcription;Goals;gut inflammation;Heart Diseases;High Fat Diet;in vivo;Inflammation;Inflammatory Bowel Diseases;Informatics;innovation;Inositol;insight;Interleukin-10;intestinal epithelium;intestinal homeostasis;Intestines;lard;Lead;Link;lipid mediator;lipid metabolism;Lipids;Literature;Mediating;Mediator;Metabolic Diseases;Metabolism;Milk;milk fat;Modeling;Molecular Chaperones;murine colitis;Mus;Myristates;novel;Nutritional;Obesity;Olive oil preparation;Organoids;Pathway interactions;Patients;phosphoproteomics;Physiology;Plants;Process;Protein Biosynthesis;Proteins;Proteomics;Publishing;Regulation;response;RNA Splicing;Role;saturated fat;Saturated Fatty Acids;Signal Transduction;Source;Soybeans;Sphingolipids;Stress;Testing;therapeutic target;Tissues;Trans Fats;Validation;XBP1 gene

PROJECT_TITLE: Sphingolipids, Dietary Fatty Acids, and Intestinal Pathophysiology

STUDY_SECTION: NMHD

STUDY_SECTION_NAME: Nutrition and Metabolism in Health and Disease Study Section[NMHD]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Disability Research;Eye Disease and Disorders of Vision;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_DEPT: PHYSIOLOGY

PHR: Disorders and disruptions to visual perception from disease and traumatic injury lead to disabilities affecting a significant population of the United States. The proposed project will use a genetic model system to study the cell-circuit mechanisms for normal feature-based visual perception, as well as how deficits are caused and ameliorated. The proposed research is expected to facilitate broader understanding of normal visual function, thereby highlighting dysfunction.

PI_NAMEs: FRYE, MARK ARTHUR (contact)

PROJECT_TERMS: 3-Dimensional;Acetylcholine;Affect;Architecture;Attention;Bathing;Behavior;Behavioral;Biogenic Amines;Biological Models;Calcium;Cells;Clutterings;Complex;Coupled;Darkness;Degenerative Disorder;Detection;detector;disability;Disability treatment;Discrimination;Disease;Disparity;Distributional Activity;Drosophila genus;Eye;feature detection;fly;Functional disorder;Funding;gamma-Aminobutyric Acid;ganglion cell;gaze;Genetic;Genetic Models;Genetic Techniques;Glutamates;Goals;Holography;Human;Hybrids;Image;in vivo imaging;Individual;Inherited;insight;kinematics;Lead;Locomotion;luminance;Maps;Measures;Modeling;Motion;motor control;Movement;Mus;Nervous System;neural circuit;Neurobiology;neuronal circuitry;Neurons;neuroregulation;Neurotransmitters;nonhuman primate;Norepinephrine;novel;object motion;Optic Lobe;Optics;optogenetics;Output;Pathway interactions;Pattern;Persons;Photic Stimulation;Physiological;Population;postsynaptic;presynaptic;Process;Property;receptive field;Reporter;Reporting;Research;response;Retinal Ganglion Cells;retinotopic;Role;Saccades;segregation;selective attention;Signal Transduction;Spatial Distribution;spatiotemporal;Speed;Stimulus;Stroke;Structure;Synapses;System;Testing;therapy development;Traumatic injury;two-photon;United States;virtual reality;Vision;Visual;Visual attention;Visual Perception;visual plasticity;visual processing;visual stimulus;Writing

PROJECT_TITLE: Neural circuits for visual feature detection

STUDY_SECTION: NTRC

STUDY_SECTION_NAME: Neurotransporters, Receptors, and Calcium Signaling Study Section[NTRC]


NIH_SPENDING_CATS: Digestive Diseases

ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: PROJECT NARRATIVE Mesenteritis is an inflammatory disease of gut mesentery; however, its cause remains unknown. We will assess the role of macrophages which reside in serous membrane of gut mesentery and their mechanism in mediating mesenteritis induced by gut inflammation. Our findings will increase our understanding of the role of membrane-associated macrophages during mesenteritis and potentially lead to the development of treatment for mesenteritis associated with gut inflammation.

PI_NAMEs: KIM, KIWOOK  (contact)

PROGRAM_OFFICER_NAME: PERRIN, PETER J

PROJECT_TERMS: abdominal CT;Ablation;Address;Adult;Affect;cell type;Cells;Chronic;Clinical;Collagen;commensal microbes;Crohn's disease;Data;Diagnosis;Disease;Embryo;enteric infection;Environment;Equilibrium;Fat necrosis;Fetal Liver;Fibrosis;Genetic;Genetic study;Genetic Transcription;Gnotobiotic;Growth;gut inflammation;Health;Homeostasis;Image;Imaging Techniques;Imaging technology;Immune response;in vivo;Inflammation;Inflammatory;Inflammatory Bowel Diseases;Inflammatory Response;Innate Immune Response;insight;Knockout Mice;Lipodystrophy;LoxP-flanked allele;Macrophage;Maintenance;Mediating;Membrane;mesenteric lymph node;Mesentery;MMP9 gene;Modeling;monocyte;mouse model;Mus;Myeloid Cells;Newborn Infant;novel;Panniculitis;Pathology;Physiologic pulse;Play;Population;prevent;progenitor;programs;recruit;Regulation;Reporter;Research Proposals;resident commensals;Resolution;Role;Salmonella typhimurium;Scanning;Serous Membrane;Shapes;Signal Transduction;Specific qualifier value;Stromal Cells;Techniques;Testing;therapeutic target;therapy development;Tissue membrane;tissue repair;Tissues;tool;transcriptomics;Whole Organism;Yolk Sac

PROJECT_TITLE: Role of membrane-associated macrophages in health and inflammation

STUDY_SECTION: GMPB

STUDY_SECTION_NAME: Gastrointestinal Mucosal Pathobiology Study Section[GMPB]


ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project narrative Cerebral cavernous malformations (CCMs) are common neurovascular lesions in which the severity of the disease is highly variable, suggesting that environmental factors may act as disease modifiers. We have discovered that hypoxic conditions worsen vascular lesions during CCM disease. We propose a new paradigm that hypoxia signaling triggered by the environment (e.g., high altitude) or pathology (e.g., obstructive sleep apnea, chronic lung disease) promote CCM lesion development and may represent a significant risk factor for brain bleedings.

PI_NAMEs: LOPEZ-RAMIREZ, MIGUEL ALEJANDRO (contact)

PROGRAM_OFFICER_NAME: KOENIG, JAMES I

PROJECT_TERMS: Adult;Affect;Altitude;Animal Model;Apoptosis;Astrocytes;Biological;Biological Factors;Blood;Blood Vessels;Brain;brain endothelial cell;Brain hemorrhage;brain size;Cardiovascular Diseases;CCM1 gene;Central Nervous System;cerebral cavernous malformations;Cerebral endothelium;cerebrovascular;Child;Chronic;Chronic lung disease;Clinical;Coculture Techniques;Combined Modality Therapy;Data;Development;Disease;Endothelial Cells;Endothelium;Environment;Environmental Risk Factor;Extravasation;Gene Expression;Genes;Genetic;Genetic Polymorphism;Gliosis;Goals;gut microbiome;Hemorrhage;Heterogeneity;HIF1A gene;Human;Hypoxia;hypoxia inducible factor 1;In Vitro;in vitro Model;Individual;Inflammatory;Intervention;Intracranial Hemorrhages;Knock-out;Lesion;lifetime risk;Literature;loss of function mutation;Messenger RNA;Methods;Modeling;modifiable risk;mouse model;Mus;Neurologic Deficit;Neurons;neurovascular;normoxia;novel therapeutic intervention;Obstructive Sleep Apnea;Oxygen;Pathogenesis;Pathologic;Pathology;Pathway interactions;Patients;pharmacologic;Predisposition;prevent;Preventive measure;profiles in patients;programs;Proteins;Research;response;Ribosomes;Risk;Risk Factors;Role;Seizures;Severity of illness;Signal Transduction;Site;Stroke;stroke risk;Testing;Tissues;TNFSF5 gene;Translating;vascular abnormality;Vascular Diseases;Vascular Endothelial Growth Factors

PROJECT_TITLE: Mechanisms of hypoxia induced exacerbation of cerebral cavernous malformations

STUDY_SECTION: BINP

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]


NIH_SPENDING_CATS: Neurosciences;Nutrition;Obesity

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Feeding has long been known to be controlled by neuronal circuits in the hypothalamus, however, we have shown that changes in the mitochondria in fat cells can also lead to increased food intake. We have also shown that the type of fats in the diet can drive increased food intake. Here we will determine how mitochondrial dynamics in fat cells and hypothalamic feeding circuits interacts with dietary fat composition to influence caloric intake.

PI_NAMEs: HORVATH, TAMAS L (contact);RODEHEFFER, MATTHEW S

PROGRAM_OFFICER_NAME: COOKE, BRAD

PROJECT_TERMS: Ablation;Adipocytes;Adipose tissue;Adult;Affect;Animals;Applications Grants;Behavior;Body Weight;Brain;Cell model;cell type;Chimeric Proteins;Data;Development;Diet;diet-induced obesity;dietary;Dietary Fats;Down-Regulation;Dynamin;Eating;Energy Intake;Energy Metabolism;Fatty acid glycerol esters;fatty acid oxidation;Fatty Acids;feeding;Feeding behaviors;Female;Food Energy;Food Intake Regulation;glucose metabolism;Hela Cells;High Fat Diet;Hypothalamic structure;In Vitro;in vivo;knock-down;Knock-out;lean body mass;Leptin;male;Mediating;Metabolism;Mitochondria;Molecular;Morphology;Mus;neuronal circuitry;Neurons;Obesity;Palmitates;Peptides;Peripheral;Phenotype;Process;Proteins;rapid weight gain;Regulation;response;Role;Satiation;Signal Transduction;System;Testing;Tissues;Transcript;Weight Gain;Work

PROJECT_TITLE: The role of mitochondrial dynamics in diet-influenced regulation of food intake and adiposity

STUDY_SECTION: CADO

STUDY_SECTION_NAME: Cellular Aspects of Diabetes and Obesity Study Section[CADO]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: AMHERST

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

PHR: Project Narrative: Children from food insecure households are at higher risk for overweight, obesity, and other chronic disease and more research is needed to identify and characterize individual, behavioral, and environmental factors that underlie these relationships. This study will examine a novel behavioral phenotype, sensitization to repeated intake of snack food, and its relationship with food insecurity, body weight and weight change over time in a cohort of adolescents from moderate to low income families. We will also examine the impact of family dynamics of food insecurity on the relationship between sensitization and weight change over time.

PI_NAMEs: TEMPLE, JENNIFER L (contact)

PROGRAM_OFFICER_NAME: OSGANIAN, VOULA

PROJECT_TERMS: 3-Dimensional;Adolescent;Adult;Behavioral;behavioral phenotyping;behavioral study;Body mass index;Body Weight;Body Weight Changes;Cardiovascular system;Caregivers;Child;Chronic Disease;cohort;Communities;Complex;Consumption;Data;Development;discounting;disorder risk;Eating;Education;Effectiveness;energy density;Energy Intake;Enrollment;Environmental Risk Factor;ethnic minority population;Ethnic Origin;Etiology;evidence base;excessive weight gain;experience;Family dynamics;feeding;Food;Food Access;food environment;food insecurity;food resource;food security;Goals;Healthy Eating;high risk;high risk population;Home;Household;Income;Individual;individualized medicine;Intake;Intervention;life span;Low income;lower income families;Mediating;member;Neighborhoods;novel;Nutritional;Obesity;obesity prevention;Occupations;Overweight;parental influence;Parents;perceived stress;Perception;Periodicals;Phenotype;Play;Population;Prevention strategy;prospective;Public Health;Race;racial minority population;Reporting;Research;Role;Sampling;Secure;Self Efficacy;social;social determinants;social health determinants;Socioeconomic Status;Testing;Time;treatment strategy;Weight;Weight Gain;Work

PROJECT_TITLE: The Role of Food Insecurity and Sensitization in Excess Weight Gain in Adolescents from Low to Moderate Income Households

STUDY_SECTION: LCBH

STUDY_SECTION_NAME: Lifestyle Change and Behavioral Health Study Section[LCBH]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Data Science;Heart Disease;Patient Safety

ORG_CITY: ATLANTA

ORG_DEPT: SURGERY

ORG_NAME: EMORY UNIVERSITY

PHR: Existing national surgical quality improvement programs have not significantly updated their processes for data collection, data analysis, or providing feedback to stakeholders in decades. Alternative strategies that could be implemented within quality improvement programs’ current infrastructure could make these programs more timely, efficient, and effective. This mixed-methods proposal will evaluate the extent to which such alternative approaches could be used to improve existing national surgical quality improvement programs.

PI_NAMEs: MASSARWEH, NADER NABILE (contact);SOX-HARRIS, ALEX

PROGRAM_OFFICER_NAME: WOLZ, MICHAEL

PROJECT_TERMS: Address;advanced analytics;American College of Surgeons;Automation;Awareness;Cardiac;Cardiac Surgery procedures;Caring;Clinical;Collection;Data;Data Analyses;Data Analytics;Data Collection;Data Element;Data Science;data warehouse;Databases;Early Diagnosis;Electronic Health Record;Evaluation;Excess Mortality;experience;Feedback;Future;Goals;Hand;hospital performance;Hospitals;implementation strategy;improved;Industry;Infrastructure;innovation;Institution;interest;Interview;Link;Manuals;Measurement;Methodology;Methods;Modeling;Modernization;Modification;mortality;National Heart, Lung, and Blood Institute;Natural Language Processing;Notification;novel;Observational Study;Operative Surgical Procedures;Outcome;Patients;Performance;Perioperative Care;Private Sector;Process;programs;Qualitative Methods;Registries;Reporting;Research;Research Personnel;Research Priority;Resources;response;Risk Adjustment;Safety;Societies;Statistical Computing;Structure;Sum;Thoracic Surgeon;Time;United States Department of Veterans Affairs;Update;Work

PROJECT_TITLE: Using Modern Data Science Methods and Advanced Analytics to Improve the Efficiency, Reliability, and Timeliness of Cardiac Surgical Quality Data

STUDY_SECTION: CDMA

STUDY_SECTION_NAME: Clinical Data Management and Analysis Study Section[CDMA]


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Genetics;Women's Health Research

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Project Narrative and Public Health Relevance Statement Silencing large regions of the genome is essential for proper cell function and these heterochromatic regions are organized at the nuclear periphery. A diagnostic marker of tumor severity and patient outcome are distortions to the size and shape of the nucleus, termed pleomorphism. The research program proposed aims to develop a fundamental understanding of heterochromatin formation at the nuclear envelope, which will provide tangible targets for cancer therapies that aim to restore proper regulation of gene expression and nuclear morphology.

PI_NAMEs: KEENEN, MADELINE  (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: Architecture;Atomic Force Microscopy;Behavior;Binding;Biochemical;Biochemistry;Biological Assay;Biological Models;Biology;Biophysical Process;biophysical properties;Biophysics;Breast Cancer cell line;breast cancer metastasis;Breast Cancer Patient;cancer cell;Cancer cell line;Cell Line;Cell Nucleus;Cell Physiology;Cells;Characteristics;Chromatin;Chromatin Fiber;Chromatin Structure;Chromosome Segregation;Complex;Confocal Microscopy;Coupled;CRISPR interference;Development;diagnostic biomarker;Disease;disease phenotype;Distal;DNA;DNA-Protein Interaction;Down-Regulation;Electron Microscopy;Estrogen receptor positive;Exhibits;experimental study;Fluorescence Microscopy;Gene Expression Regulation;gene repression;Gene Silencing;Gene Structure;Genes;Genetic Transcription;Genome;Goals;Heterochromatin;heterochromatin-specific nonhistone chromosomal protein HP-1;Histologic;Histone H3;histone methylation;histone modification;In Vitro;in vivo;Individual;Injections;Integral Membrane Protein;Intermediate Filament Proteins;Invaded;Label;lamin B receptor;Lamin Type B;Lamins;Length;Liquid substance;Lysine;Malignant Breast Neoplasm;Malignant Neoplasms;MCF7 cell;Mechanics;Mediating;Mediator;Membrane;Metastatic/Recurrent;Methylation;micronucleus;migration;Modification;Molecular;Monitor;Morphology;mouse model;Mus;Neoplasm Metastasis;neoplastic cell;novel;Nuclear;Nuclear Envelope;Nuclear Inner Membrane;Nuclear Pleomorphism;Nucleosomes;Organism;Output;overexpression;Patient-Focused Outcomes;Phase;physical model;Physiological;Play;Pleomorphism;Postdoctoral Fellow;programs;Proliferating;protein expression;Protein Region;Proteins;public health relevance;receptor binding;reconstitution;recruit;Research;Research Project Grants;restoration;Role;Severities;Shapes;single molecule;Sum;System;T47D;targeted cancer therapy;Techniques;Tertiary Protein Structure;Testing;therapy development;Time;Trophoblast Cancer;Tumor Markers;tumor progression;ultra high resolution;Up-Regulation;Variant;Visualization;Work

PROJECT_TITLE: Dissecting the mechanistic role of multinucleation in breast and trophoblast cancers


NIH_SPENDING_CATS: Biotechnology;Cancer;Hematology;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Precision Medicine;Prevention;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_CITY: CHARLESTON

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: NARRATIVE (PUBLIC RELEVANCE) Allogeneic hematopoietic cell transplantation (HCT) is a potentially curative therapy for many inherited and malignant diseases whose applicability has been impeded by the development of one of its most serious complication, chronic graft versus host disease (cGVHD). Unfortunately, there is no validated blood test for predicting the risk of developing cGVHD. Strategies that identify and validate biomarkers for risk of cGVHD occurrence will allow for personalized therapies that will be more efficient if introduced early in the course of the disease in many patients with hematological cancers.

PI_NAMEs: LOGAN, BRENT R;PACZESNY, SOPHIE  (contact)

PROGRAM_OFFICER_NAME: SHELBURNE, NONNIEKAYE F

PROJECT_TERMS: Address;Adult;Algorithms;Allogenic;Archives;B-Cell Activation;biobank;Biological;Biological Markers;Biology;biomarker identification;biomarker panel;biomarker validation;Blood;Blood specimen;Blood Tests;Bone Marrow Transplantation;candidate identification;CCR5 gene;CD276 gene;Cells;chemokine;Child;Childhood;chronic graft versus host disease;Clinical;Clinical Trials Network;cohort;Complication;Cryopreservation;CSF1 gene;curative treatments;CXCL10 gene;CXCR3 gene;Cytometry;Dana-Farber Cancer Institute;Data;deep learning;Dendritic Cells;Development;dimension reduction;Disease;Disease susceptibility;disorder control;disorder risk;Enzyme-Linked Immunosorbent Assay;experimental study;FOXP3 gene;Frequencies;Helper-Inducer T-Lymphocyte;Hematologic Neoplasms;Hematopoietic Stem Cell Transplantation;high dimensionality;high risk;Hispanic;IL17 gene;Immunosuppression;improved;Incidence;Inherited;Interleukins;Ligands;Machine Learning;machine learning algorithm;Malignant - descriptor;MCAM gene;Measures;Modeling;novel;novel marker;osteopontin;Patients;Peripheral Blood Mononuclear Cell;personalized medicine;Plasma;Plasma Proteins;Population;Positioning Attribute;predictive marker;Proteomics;Publishing;Random Allocation;RANTES;receptor;Regimen;Regulatory T-Lymphocyte;Relapse;Research;Risk;risk prediction;risk stratification;Sample Size;Sampling;Sensitivity and Specificity;statistics;Steroids;Stromelysin 1;success;Symptoms;T-Lymphocyte;tandem mass spectrometry;Techniques;Testing;Tissue Banks;Training;Transplant Recipients;Trees;Validation

PROJECT_TITLE: Machine Learning to identify Biomarkers for Risk of Chronic Graft-Versus-Host Disease

STUDY_SECTION: CBSS

STUDY_SECTION_NAME: Cancer Biomarkers Study Section[CBSS]