NIH_SPENDING_CATS: Bioengineering;Cancer;Clinical Research;Genetic Testing;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Precision Medicine;Prevention;Prostate Cancer;Social Determinants of Health;Urologic Diseases

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: PROJECT NARRATIVE Revolutionary advances in cancer detection technologies promise to improve patients' lives, but timely evaluation is challenging. This project will support rigorous statistical modeling and analyses to close gaps in evidence for new and established cancer diagnostic tests, including developing sound screening and confirmation protocols, investigating precision treatments, and identifying pathways to narrow health disparities.

PI_NAMEs: GULATI, ROMAN  (contact)

PROGRAM_OFFICER_NAME: ZHU, LI

PROJECT_TERMS: Address;Award;Basic Science;biomathematics;Biometry;Biostatistical Methods;Cancer Control;Cancer Detection;Cancer Diagnostics;Cancer Model;Cancer Research Project;Cancer Surveillance Research Program;care delivery;Clinical;Clinical Trials;Collaborations;Communication;Computer Models;computer program;Data Analyses;Data Analytics;data modeling;detection test;diagnostic technologies;Diagnostic tests;Early Diagnosis;Early treatment;Evaluation;experimental study;Fostering;Generations;health disparity;improved;Lead;Leadership;Malignant neoplasm of prostate;Methods;Modeling;Natural History;novel;Outcome;Pathway interactions;Patients;Peer Review;Phase;Policies;Policy Developments;Population;Precision therapeutics;Principal Investigator;Productivity;Program Research Project Grants;programs;Protocols documentation;Reduce health disparities;Research;research study;Research Support;Scientific Inquiry;screening;Screening for cancer;Services;skills;sound;Specialist;Statistical Data Interpretation;Statistical Models;Study models;Technology;translational cancer research;treatment strategy;Uncertainty

PROJECT_TITLE: Statistical modeling to support population and translational cancer research


ADMINISTERING_IC: NS

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Machine Learning and Artificial Intelligence;Neurosciences

ORG_CITY: HADLEY

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF MASSACHUSETTS AMHERST

ORG_STATE: MA

PHR: PROJECT NARRATIVE Many neurological conditions result from problems arising during development, yet a fundamental understanding of how neurogenesis adds new neurons to functioning circuits is lacking. This project creates five complete wiring diagrams of brains at different stages of development in a small tractable animal. The results will provide insights into how larger networks, including the human brain, continue to function while adding more neurons.

PI_NAMEs: KATZ, PAUL S (contact)

PROGRAM_OFFICER_NAME: LAVAUTE, TIMOTHY M

PROJECT_TERMS: 3-Dimensional;Address;Adolescent;Adult;Animal Model;Animals;Atlases;automated segmentation;Axon;Brain;cell type;Classification;Computers;connectome;course development;Data Set;Dendrites;Development;Distant;Efferent Neurons;Electron Microscope;Electron Microscopy;Electrons;Enzymes;Eye;Ganglia;Gene Expression;Gene Expression Profile;Generations;Growth;Human;Image;In Situ Hybridization;Individual;insight;Label;Learning;Location;Machine Learning;machine learning algorithm;machine learning classification;Maps;mature animal;Messenger RNA;microscopic imaging;model organism;Motor;motor control;Nerve;Nervous System Disorder;network architecture;neural;neural circuit;neurodevelopment;neurogenesis;Neurologic;neuron development;neuronal cell body;Neurons;Neurophysiology - biologic function;Neurosciences;Neurotransmitters;novel;Organism;Phenotype;postsynaptic;presynaptic;Process;Reaction;reconstruction;Rest;sample fixation;Scanning;Sensory;Series;Standard Model;Structure;Synapses;synaptogenesis;System;Testing;Thick;Time;Tracer;transcription factor;Vertebrates;Visual

PROJECT_TITLE: A Connectomic Analysis of a Developing Brain Undergoing Neurogenesis

STUDY_SECTION: NC

STUDY_SECTION_NAME: Neuronal Communications Study Section[NC]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Infectious Diseases;Sexually Transmitted Infections

ORG_CITY: OMAHA

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: Project Narrative: Characterizing the Redoxome of Chlamydia and Its Host Cell Chlamydiae are important pathogens of humans and significant causes of morbidity, causing a range of illnesses including sexually transmitted diseases, trachoma, pneumonia, and other respiratory tract infections. The burden of these infections stems from their lack of symptoms, which can lead to chronic conditions such as infertility, adult-onset asthma, and, in some cases, possibly exacerbating heart disease. The work proposed here is to identify redox-regulated proteins in both the host and pathogen, which in turn will lead to follow-up studies to understand their importance in the biology of infection with this important pathogen.

PI_NAMEs: OUELLETTE, SCOT P (contact)

PROGRAM_OFFICER_NAME: VINCENT, LEAH REBECCA

PROJECT_TERMS: Address;Adult;Affect;Asthma;Bacteria;Bacterial Proteins;Biology;Blindness;candidate identification;candidate selection;Cell Culture Techniques;Cells;Centers for Disease Control and Prevention (U.S.);Characteristics;Chlamydia;Chlamydia Infections;Chlamydia trachomatis;Chronic;Complex;Complication;Dependence;design;Developed Countries;Developing Countries;Development;Disease;disulfide bond;environmental change;Equilibrium;experimental study;Follow-Up Studies;Funding;Gene Expression Profile;Genes;Genetic;Genetic Techniques;Genome;Goals;Growth;Growth and Development function;Healthcare Systems;Heart Diseases;Human;human pathogen;In Vitro;in vivo;Incidence;Infection;infection burden;Infertility;Link;Maps;Mass Spectrum Analysis;Mediator;Metabolic;Morbidity - disease rate;Morphology;mutant;Mutate;NADP;normal microbiota;novel therapeutics;Organism;oxidation;Oxidation-Reduction;pathogen;Pathogenesis;pathogenic bacteria;Pathway interactions;Patients;Pelvic Inflammatory Disease;Pneumonia;prevent;Proteins;Reducing Agents;Regulation;Reiter Disease;Reporting;Respiratory Tract Infections;Sexually Transmitted Diseases;Side;Signal Transduction;stem;Symptoms;System;Techniques;Therapeutic Agents;thioredoxin reductase;Time;tool;Trachoma;tubal infertility;TXN gene;Work

STUDY_SECTION: BHI

STUDY_SECTION_NAME: Bacterial-Host Interactions Study Section [BHI]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Digestive Diseases;Genetics;Liver Cancer;Liver Disease;Lung;Lung Cancer;Rare Diseases

ORG_CITY: WORCESTER

ORG_DEPT: GENETICS

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: Project Narrative Cancer models with translational value require rapid and flexible in vivo genome-editing platforms. This proposal seeks to optimize an accessible CRISPR prime editing-based approach to make somatic mouse models of cancer. Completing this project will result in new mouse models of cancer, validate driver mutations in liver and lung cancer, and enhance the translational utility of cancer models.

PI_NAMEs: XUE, WEN  (contact)

PROGRAM_OFFICER_NAME: BENAVIDEZ, JUSTIN MICHAEL

PROJECT_TERMS: Address;Adult;Alleles;base;base editing;base editor;Biological Markers;Biotechnology;Bypass;cancer genomics;Cancer Model;cell type;Clustered Regularly Interspaced Short Palindromic Repeats;Code;Communities;Complex;CRISPR/Cas technology;delivery vehicle;design;Disease Progression;Dissection;DNA Repair;driver mutation;drug sensitivity;Endonuclease I;Engineering;Enzymes;flexibility;Foundations;Gene Targeting;Generations;Genes;Genome;genome editing;Genomics;Germ Lines;Goals;Guide RNA;Histology;Human;human disease;human model;improved;in vivo;in vivo Model;insertion/deletion mutation;insight;Intervention;Knock-in;Liver;liver cancer model;LoxP-flanked allele;Lung;Malignant neoplasm of liver;Malignant neoplasm of lung;Malignant Neoplasms;Methods;Modeling;Molecular;mouse model;Mus;Mutation;new therapeutic target;Non-Viral Vector;Nucleic Acid Regulatory Sequences;oncogene addiction;Oncogenes;Oncogenic;Organ;Phenotype;Point Mutation;pre-clinical;prime editing;prime editor;Reagent;recombinase;repaired;Research;RNA-Directed DNA Polymerase;Sequence Deletion;Site;Speed;System;Technology;Testing;therapy resistant;Time;Tissues;tool;translational cancer research;tumor growth;Validation;Variant;Viral Vector;Work

PROJECT_TITLE: In vivo prime editing for precision cancer mouse models

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CTH-E(55)R]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Congenital Structural Anomalies;Genetics;Human Genome;Neurosciences;Pediatric

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

PHR: PROJECT NARRATIVE Dysregulation of gene networks during development can lead to organ malformation, dysfunction and disease, including neurological diseases such as schizophrenia, Huntington’s and Alzheimer’s disease. Here, I propose to define the genetic networks regulated by the microRNA miR-9-2 at cellular resolution using an in vivo miR-9- 2 knock-out mouse model that presents with severe brain malformation. This project will fill a gap in our knowledge regarding the specific role of miR-9-2 in cell types of the developing brain, its function as a genetic regulator and its contribution to disease.

PI_NAMEs: FREGOSO, SANTIAGO P (contact)

PROGRAM_OFFICER_NAME: KIM, JENNY LILY

PROJECT_TERMS: Alzheimer's Disease;ATAC-seq;Brain;brain malformation;Cell Physiology;cell type;Cells;Cellular Morphology;Central Nervous System;Cerebral cortex;Chromatin;critical period;Data;Development;Disease;Dose;Elements;Embryo;Enhancers;Epigenetic Process;epigenetic regulation;Etiology;experimental study;Family;Family member;Fellowship;Forebrain Development;Functional disorder;Gene Dosage;Gene Expression;Gene Expression Regulation;gene network;gene regulatory network;Genes;Genetic;Genomics;Goals;Heterozygote;Hippocampus;Histologic;Huntington Disease;Hydrocephalus;In Situ Hybridization;in vivo;insight;Knock-out;Knockout Mice;Knowledge;lateral ventricle;Learning;malformation;Methodology;Methods;MicroRNAs;migration;Molecular;mouse model;multiple omics;Mus;mutant;Mutant Strains Mice;nerve stem cell;Nervous System Disorder;neural;neurodevelopment;Neurons;novel strategies;Organ;Parkinson Disease;Pattern;Phenotype;Play;Population;Post-Transcriptional Regulation;postnatal;posttranscriptional;Prevalence;Prosencephalon;Regulation;Regulator Genes;Regulatory Element;Research;Resolution;Role;Schizophrenia;Severities;single-cell RNA sequencing;spatiotemporal;stem cell proliferation;Structure;Telencephalon;Testing;Transcript;Transcriptional Regulation;transcriptomics;Untranslated RNA

PROJECT_TITLE: Defining the cell type-specific role of miR-9-2 in telencephalon development

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-2 Study Section [NST-2]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Childhood Leukemia;Genetics;Hematology;Human Genome;Orphan Drug;Pediatric;Pediatric Cancer;Precision Medicine;Rare Diseases

ORG_CITY: MEMPHIS

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

ORG_STATE: TN

PHR: NARRATIVE (RELEVANCE STATEMENT) Acute leukemia (ALL) is the commonest childhood tumor and a leading cause of cancer death in the young. My research has used integrated genomic discovery, experimental modeling and therapeutic development to identify and characterize the genomic drivers of disease and develop new treatment approaches. My proposed research program will build upon my prior discoveries to pursue several new conceptually and technically innovative areas central to advancing cure rates for these diseases, including the mechanistic basis of enhancer deregulation in leukemia, the role of BCL11B in lineage ambiguous leukemia, the mechanistic role and potential for therapeutic targeting of LMO2/STAG2 alterations in leukemia, the role of liquid-liquid phase separation mediated by fusion oncoproteins in leukemia, and their potential for therapeutic targeting. I will also develop innovative protein degradation approaches using molecular glues to degrade hitherto intractable cancer drivers of high-risk leukemia.

PI_NAMEs: MULLIGHAN, CHARLES G. (contact)

PROGRAM_OFFICER_NAME: KLAUZINSKA, MALGORZATA

PROJECT_TERMS: Acute;Acute leukemia;adult leukemia;Area;Bar Codes;Cancer Etiology;Cause of Death;Cell Lineage;Cells;Cessation of life;Childhood Leukemia;Chromatin;Clonal Evolution;Collaborations;Development;Disease;Engineering;Enhancers;Event;Experimental Models;Fusion Oncogene Proteins;Gene Expression;Genetic Transcription;Genomics;Glues;Goals;Hematopoietic;high risk;improved;improved outcome;innovation;insight;leukemia;leukemogenesis;Liquid substance;LMO2 gene;Malignant Neoplasms;Mediating;Molecular;Molecular Bank;mouse model;multiple omics;novel;novel diagnostics;novel therapeutic intervention;Pediatric Neoplasm;Phase;Physical condensation;programs;protein degradation;Research;Role;small molecule libraries;targeted treatment;Taxonomy;Therapeutic;therapeutic development;therapeutic target;Translating;Treatment Failure

PROJECT_TITLE: Translating genomic discoveries to improved outcomes for high risk acute leukemia


NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Patient Safety;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Rehabilitation;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_CITY: CLEVELAND

ORG_DEPT: PHYSICAL MEDICINE & REHAB

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PI_NAMEs: BRYDEN, ANNE ;KILGORE, KEVIN L. (contact);MOYNAHAN, MEGAN

PROGRAM_OFFICER_NAME: GROSS, BROOKS ANDREW

PROJECT_TERMS: arm function;biomaterial compatibility;Case Report Form;Cervical;Cervical spinal cord injury;Charge;Clinical;clinical application;Clinical Protocols;Clinical Research;clinical research site;clinical training;Clinical Trials;commercialization;Consent Forms;Coupled;Data;Data Collection;Data Set;design;Development;Devices;Documentation;Effectiveness;effectiveness testing;Electromagnetics;Enrollment;Evaluation;experience;Feasibility Studies;feasibility testing;Future;Generations;Goals;good laboratory practice;grasp;Hand;Hand functions;hand rehabilitation;Implant;implantation;Individual;Injury;Institution;Magnetic Resonance Imaging;Manuals;manufacture;manufacturing process;manufacturing systems;Marketing;Medical;Methods;Modification;Multicenter Studies;neuroprosthesis;operation;Operative Surgical Procedures;Outcome;Outcome Assessment;Outcome Measure;Patients;Persons;Phase;Population;Preparation;Procedures;product development;Protocols documentation;Qualifying;Rare Diseases;Readiness;recruit;Research Design;restoration;screening;Site;Software Validation;Spinal cord injury;Standardization;Study Subject;Surgeon;Synapses;System;Technology;Technology Transfer;Testing;Training;training opportunity;Training Programs;Translations;Update;Validation;verification and validation;Work

PROJECT_TITLE: Restoration of Grasp and Reach in Cervical Spinal Cord Injury


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: SALT LAKE CITY

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Project Narrative The scientific premise of this Center is that breast cancer patient-derived xenograft (PDX) models represent the diversity of human breast tumors, and can be feasibly utilized to test new drugs and drug combinations to find therapeutic approaches that match with molecular features of various tumor types. The goal of our PDX Development and Trials Center (PDTC) is to obtain preclinical data that will facilitate prioritization of drugs to be tested in clinical trials at the National Cancer Institute (NCI). Toward this goal, our PDTC focuses on testing drugs that are already available through the NCI as NCI-IND agents with the Experimental Therapeutics Clinical Trials Network (ETCTN).

PI_NAMEs: LEWIS, MICHAEL T.;MARTH, GABOR T;WELM, ALANA L (contact)

PROGRAM_OFFICER_NAME: HENDERSON, LORI A

PROJECT_TERMS: advanced breast cancer;Algorithms;Animals;Bioinformatics;Biometry;Breast;Breast Cancer Patient;Breast Cancer therapy;Cancer Biology;cancer clinical trial;Cancer Etiology;cancer recurrence;care outcomes;Cellular biology;Cessation of life;Chemoresistance;chemotherapy;Clinical Trials;Clinical Trials Network;cohort;Collaborations;Collection;college;combat;Combined Modality Therapy;Communication;Data;design;Development;Disease;Drug Combinations;drug testing;Early treatment;effective therapy;Elements;ethnic minority;Evolution;experience;Fostering;Funding;Future;Generations;Genomics;Goals;Human;Huntsman Cancer Institute at the University of Utah;improved;improved outcome;innovation;Institution;inter-institutional;interactive visualization;Investigational Therapies;Investments;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Neoplasms;Medicine;Metastatic/Recurrent;Modeling;Molecular;Molecular Genetics;Molecular Profiling;multidisciplinary;National Cancer Institute;Neoplasm Metastasis;novel;novel therapeutic intervention;novel therapeutics;Organoids;Pathology;patient derived xenograft model;patient population;Patient-derived xenograft models of breast cancer;Pharmaceutical Preparations;Pharmacotherapy;Pilot Projects;pre-clinical;pre-clinical research;Preclinical Drug Evaluation;preclinical trial;prevent;racial minority;Recurrence;Recurrent disease;Regimen;Reproducibility;Research;Research Project Grants;Resistance;response;Sampling;standard of care;Structure;synergism;targeted treatment;Testing;Therapeutic;therapeutic evaluation;Treatment Protocols;treatment strategy;triple-negative invasive breast carcinoma;tumor;Veterinary Medicine;web-based tool;Women's mortality

PROJECT_TITLE: PDX Trial Center for Breast Cancer Therapy


NIH_SPENDING_CATS: Breast Cancer;Cancer;Women's Health Research

PI_NAMEs: WELM, ALANA L (contact)

PROJECT_TERMS: Accounting;Achievement;Animal Experimentation;Annual Reports;Award;Breast Cancer therapy;cohesion;Collaborations;college;Communication;Data Commons;data sharing;Elements;Ensure;Environment;Expenditure;Funding;Guidelines;Human;IACUC;improved;Institution;Institutional Review Boards;Malignant Neoplasms;Medicine;meetings;member;Occupational activity of managing finances;operation;Personnel Staffing;Pilot Projects;Policies;Preparation;Procedures;programs;Publications;Records;Reporting;Research;Research Personnel;Resource Allocation;Resource Sharing;Resources;Schedule;Scientific Advances and Accomplishments;Structure;success;Travel;United States National Institutes of Health;Universities;Utah;Vertebrates

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Women's Health Research

PI_NAMEs: LEWIS, MICHAEL T. (contact)

PROJECT_TERMS: Animals;anti-cancer research;Bioinformatics;Breast;Breast Cancer therapy;cancer prevention;cancer subtypes;Characteristics;Collaborations;Collection;college;Communities;Core Facility;cost effective;Data;Data Analyses;Data Commons;Data Display;data exchange;Development;Drug resistance;ethnic diversity;Goals;Grant;Growth and Development function;Human;in vivo Model;individual patient;Infrastructure;Institution;Joints;Logistics;Maintenance;Malignant Breast Neoplasm;Malignant Neoplasms;Medicine;Modeling;Modification;Molecular;Mus;Organ;pathogen;patient derived xenograft model;Patients;Pharmaceutical Preparations;Pharmacotherapy;Pilot Projects;Population Heterogeneity;preclinical trial;Procedures;programs;Quality Control;racial diversity;refractory cancer;repository;Reproducibility;Research;Research Institute;Research Project Grants;Resources;response;Sampling;Site;standard of care;success;technology development;Testing;Texas;Therapeutic;Tissue Sample;treatment response;tumor

PROJECT_TITLE: PDX Core


PI_NAMEs: MARTH, GABOR T (contact)

PROJECT_TERMS: Animals;Bioinformatics;Biostatistics Core;Breast Cancer therapy;Budgets;Collaborations;college;Complex;Computer software;Core Facility;cost effective;Data;Data Analyses;Data Commons;data repository;Databases;design;Development;experimental analysis;Experimental Designs;Funding;Goals;Human Resources;Institution;Malignant Neoplasms;Manuscripts;Medicine;Modeling;Molecular;novel strategies;operation;Organoids;Participant;Patients;Pharmaceutical Preparations;Pharmacotherapy;Pilot Projects;preclinical trial;Procedures;Recording of previous events;Reporting;Research;Research Personnel;Research Project Grants;Resource Sharing;Resources;response;Site;Standardization;Statistical Models;success;tumor;Work;Writing

PROJECT_TITLE: Bioinformatics Core


NIH_SPENDING_CATS: Bioengineering;Burden of Illness;Cancer;Colorectal Cancer;Digestive Diseases;Microbiome;Networking and Information Technology R&D (NITRD);Prevention

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Project Narrative The objective of the proposed project is to gain insights into the interactive role of exposures, microbiota, immune cells, and tumor cells in colorectal cancer (CRC) and adenoma by conducting integrative epidemiological analyses of immunology and microbiology. Moreover, this project will develop novel statistical and computational methods for such analyses. Our integrative approach will not only provide the scientific foundation for exploring roles of anti-tumor immunity and microbiota in CRC development, but also contribute to advancing several fronts of biomedical and public health sciences.

PI_NAMEs: UGAI, TOMOTAKA  (contact)

PROGRAM_OFFICER_NAME: SIMONDS, NAOKO ISHIBE

PROJECT_TERMS: adenoma;Biological Assay;Biological Markers;Cancer and Leukemia Group B;Cancer Science;carcinogenicity;Cells;Characteristics;Clinical;cohort;Cohort Studies;Colonoscopy;Colorectal Adenoma;Colorectal Cancer;Computational algorithm;Computing Methodologies;Data;Data Set;Databases;Development;Diet;digital imaging;Disease;early onset colorectal cancer;Epidemiology;Etiology;Follow-Up Studies;Foundations;Genetic;Health Professional;Health Sciences;high dimensionality;Image Analysis;Immune;Immunity;Immunology;Incidence;insight;lifestyle factors;machine learning algorithm;Mediation;microbial;Microbiology;microbiota;microorganism;modifiable lifestyle factors;Molecular;molecular pathology;multi-ethnic;neoplastic cell;novel;Nurses' Health Study;Outcome;Pathologic;Pattern;Population;predictive modeling;Prevention strategy;Process;Prognostic Factor;Public Health;Research;Risk Factors;Role;Somatic Mutation;Southwest Oncology Group;Statistical Methods;tumor;Tumor Immunity;tumor microbiota;tumor microenvironment;Tumor Subtype;Tumor Tissue;Variant

PROJECT_TITLE: Integration of Immunology and Microbiology into Molecular Pathological Epidemiology of Colorectal Cancer


NIH_SPENDING_CATS: Aging;Biotechnology;Breast Cancer;Cancer;Health Disparities and Racial or Ethnic Minority Health Research;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research;Women's Health Research

PROJECT_TERMS: Adjuvant;Adjuvant Chemotherapy;African American;African American population;American Indians;Asian population;biomarker identification;Breast Cancer Patient;Breast Cancer Prevention;Breast Cancer therapy;cancer recurrence;Carboplatin;Cause of Death;chemotherapy;Cisplatin;Clinical;Clinical Trials;co-clinical trial;cohort;Collection;Combination Drug Therapy;Combined Modality Therapy;Computing Methodologies;Coupled;cytotoxic;Cytotoxic Chemotherapy;Data;Data Set;Disease;Disease Outcome;Distant;docetaxel;Dose;drug candidate;drug response prediction;Epidermal Growth Factor Receptor;Ethnic Origin;follow-up;Generations;Goals;Grant;Hand;Hispanic Populations;Hispanic Women;hormone receptor-positive;Human;Immune checkpoint inhibitor;improved;In complete remission;in vivo;Malignant Breast Neoplasm;Measurable;Metastatic/Recurrent;Modeling;Molecular Computations;Molecular Target;molecular targeted therapies;Monitoring for Recurrence;Neoadjuvant Therapy;Newly Diagnosed;Oncogenic;Operative Surgical Procedures;Organoids;overexpression;Paclitaxel;Pathway interactions;patient derived xenograft model;Patient Selection;Patient-derived xenograft models of breast cancer;Patients;Platinum Compounds;Poly(ADP-ribose) Polymerase Inhibitor;pre-clinical;predicting response;predictive marker;predictive signature;prevent;prospective;Proteins;Publishing;racial population;Random Allocation;Recurrence;Refugees;Research Project Grants;Residual Neoplasm;Resistance;responders and non-responders;response;response biomarker;Salvage Therapy;screening;Slice;Survival Rate;System;targeted agent;taxane;Testing;Time;Toxic effect;treatment response;triple-negative invasive breast carcinoma;tumor;White Women

PROJECT_TITLE: Research Project 1: Enhancing neoadjuvant therapy to prevent breast cancer recurrence


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases

PHR: Project Narrative While the emerging field of archeovirology has enabled the characterization of viral infections that profoundly altered human history, important technical limitations remain that restrict its potential to uncover the evolutionary history of highly pathogenic viral families, especially RNA viruses. Using a multidisciplinary and innovative approach, this proposal will identify viruses that existed in the past ~500 years, understand the origin and evolution of important human pathogens, and reveal functional variation that contribute to their pathogenesis. The results of this proposal will shed light on the etiology of past disease outbreaks and epidemics, estimate when those viruses were introduced into human populations, and develop strategies to better prepare against future viral pandemics.

PI_NAMEs: BLANCO-MELO, DANIEL  (contact)

PROGRAM_OFFICER_NAME: BOZICK, BROOKE ALLISON

PROJECT_TERMS: 2019-nCoV;Address;Calibration;career;Cells;clinically significant;Collection;Complement;Development;Disease;Disease Outbreaks;DNA;DNA Viruses;Documentation;ds-DNA;Ebola virus;Epidemic;Etiology;Evolution;Family;Forensic Medicine;Future;Genome;Genomics;Goals;Great Britain;HIV;Human;human pathogen;Immunology;improved;Individual;Industrialization;Influenza A virus;innovation;Knowledge;Lead;Life Cycle Stages;Link;lung preservation;Measles;Medical;Methodology;Mexico;microbial genome;Modeling;Modernization;Molecular;molecular clock;Morbidity - disease rate;mortality;multidisciplinary;Museums;novel strategies;Paleontology;pandemic disease;pathogen;Pathogenesis;pathogenic virus;Pathogenicity;Pathology;Poliomyelitis;Population;Positioning Attribute;post-doctoral training;Prevention strategy;previous epidemic;Property;protein function;Proteomics;Protocols documentation;reconstruction;Recording of previous events;Records;Research;Respiratory Tract Infections;RNA;RNA Viruses;Sampling;skills;Smallpox;socioeconomics;Spain;Specimen;symptomatology;Symptoms;synergism;Techniques;technology development;tissue tropism;transmission process;Variant;Viral;viral epidemic;Viral Genes;Viral Genome;viral outbreak;viral pandemic;Viral Proteins;viral RNA;virology;Virulent;Virus;Virus Diseases;virus identification;Work

PROJECT_TITLE: Deciphering long-term virus evolution through the reconstruction of past viral genomes


ADMINISTERING_IC: GM

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Biotechnology

ORG_CITY: RIVERSIDE

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA RIVERSIDE

ORG_STATE: CA

PHR: Low-cost small molecule diagnostics, such as drug test kits for home use, have many biomedical applications, including point-of-care diagnostics, in-home tests, and environmental monitoring. We will develop a new technology that makes it much easier, faster, and cheaper to develop new tests.

PI_NAMEs: CUTLER, SEAN  (contact)

PROGRAM_OFFICER_NAME: ASLAN, KADIR

PROJECT_TERMS: Abscisic Acid;Acceleration;Acids;Address;Affinity;analog;Antibodies;Basic Science;Binding;Biochemical;Biological;Biological Assay;Biomedical Research;Biosensor;Biotechnology;Carrier Proteins;chemical synthesis;Chemicals;Chemistry;Clinical;clinical diagnostics;computational pipelines;Consumption;cost;Deposition;design;Detection;detection limit;detection platform;Development;Diagnostic;Diagnostic Reagent Kits;Diagnostic tests;Dimerization;Directed Molecular Evolution;drug testing;empowerment;Engineering;Environmental Monitoring;Enzymes;experience;FDA approved;Genetic;high throughput screening;Home;home test;Immobilization;Immunoassay;immunogenic;improved;interest;Kinetics;Legal;Libraries;Ligands;Mediating;Medical;meter;Methods;multiplex diagnostics;Mutation;Natural Products;new technology;novel diagnostics;parallelization;Pharmaceutical Preparations;Plants;point-of-care diagnostics;Process;Protein Engineering;Proteins;public repository;receptor;Receptor Activation;reconstitution;Research;scaffold;sensor;small molecule;Specific qualifier value;Speed;Substance of Abuse;Surface;Technology;Testing;Therapeutic;Time;tool;Work;Workplace

PROJECT_TITLE: Diagnostics on demand: a biosensor platform for multiplexed small molecule detection

STUDY_SECTION: EBIT

STUDY_SECTION_NAME: Enabling Bioanalytical and Imaging Technologies Study Section[EBIT]


ADMINISTERING_IC: LM

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Diabetes;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Palliative Care;Patient Safety;Prevention;Social Determinants of Health

ORG_CITY: ANN ARBOR

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE (PUBLIC HEALTH SIGNIFICANCE) People with sensory disabilities – such as people who are deaf, blind, or DeafBlind – are an overlooked population with significant health inequities due to inaccessible healthcare and health information resources. Despite this gap, few patient health education materials are designed with their information and accessibility needs in mind. The purpose of this proposed study is to (1) conduct surveys and focus groups with people with sensory disabilities to understand their health information needs, (2) develop an evidence-based checklist for patient health education material developers to use to meet these needs, and (3) create and curate publicly available digital content to improve advanced care planning and diabetes prevention among people with sensory disabilities.

PI_NAMEs: JAMES, TYLER G (contact);MCKEE, MICHAEL M

PROGRAM_OFFICER_NAME: YOON, SUNG SUG

PROJECT_TERMS: 504 plan;Access to Information;Address;Adult;Advance Care Planning;Affordable Care Act;Amendment;Americans with Disabilities Act;Area;Assessment tool;Attention;Behavior;blind;Blindness;Caring;Civil Rights;Communication;Communities;deaf;Deafblind;deafness;design;Development;diabetes management;Diabetes Mellitus;Diabetes prevention;digital;digital health;Disabilities experience;disability;Disabled Persons;Disparity;Education;Educational Assessment;Educational Materials;end of life care;evidence base;Feedback;Focus Groups;Funding;Guidelines;hard of hearing;Health;health disparity;health disparity populations;Health education;health equity;health inequalities;Health Promotion;Health Promotion and Education;Health Resources;Health system;Healthcare;Healthcare Systems;hearing impairment;high risk;improved;indexing;Individual;Inequity;Information Resources;Internet;Intervention;Laws;Learning;Librarians;Libraries;low health literacy;marginalization;Medical;medical services inaccessibility;MedlinePlus;Mental Health;Methods;Needs Assessment;neglect;Online Systems;Patient Education;Patients;Persons;physical conditioning;poor health outcome;Population;Printing;programs;Public Health;reading difficulties;Recommendation;Rehabilitation therapy;Reporting;Research;Resources;Risk;Sensory disabilities;Surveys;System;tool;United States Agency for Healthcare Research and Quality;United States National Library of Medicine;usability;user centered design;Vision;Visual impairment;web page;web site;Work

PROJECT_TITLE: DEVELOPING PATIENT EDUCATION MATERIALS TO ADDRESS THE NEEDS OF PATIENTS WITH SENSORY DISABILITIES

STUDY_SECTION: BLR

STUDY_SECTION_NAME: Biomedical Informatics, Library and Data Sciences Review Committee[BLR]


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Precision Medicine;Women's Health Research

PROJECT_TERMS: Biological Markers;Biological Models;biomarker identification;Breast Cancer Patient;Breast Cancer therapy;Cancer cell line;Cancer Etiology;Cancer Model;cancer subtypes;Cessation of life;chemotherapy;Clinic;Clinical;Clinical Trials;Clinical Trials Design;cohort;Collection;Computational algorithm;cost;Data;Data Set;Disease;Drug Combinations;drug efficacy;Drug Exposure;Drug resistance;effective therapy;efficacious treatment;efficacy evaluation;established cell line;Evolution;Failure;FDA approved;Genomics;Goals;Heterogeneity;high risk;Human;improved;in vivo;Investigational Drugs;Lead;Longitudinal cohort;Malignant Breast Neoplasm;Mammary Neoplasms;Medical;Metastatic breast cancer;Metastatic/Recurrent;Methods;Minority Groups;minority patient;Modeling;molecular marker;National Cancer Institute;Neoplasm Metastasis;novel;novel therapeutics;Organoids;Outcome;Outcome Study;patient derived xenograft model;patient population;patient response;Patient Selection;Patients;Pharmaceutical Preparations;pre-clinical;Primary Neoplasm;primary outcome;Recurrence;Research;Research Project Grants;Resistance;Resources;responders and non-responders;response;response biomarker;Sampling;screening;Slice;synergism;Therapeutic;therapy resistant;Time;Tissues;tool;Translating;Treatment Protocols;tumor;Tumor Burden;Underrepresented Minority;Utah;Women's mortality;Work

PROJECT_TITLE: Research Project 2: Identify and validate efficacious therapies for metastatic breast cancer


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Sleep Research

ORG_CITY: CHARLESTON

ORG_DEPT: PSYCHIATRY

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: An important goal of neuroscience is to identify how activity in specific circuits in the brain regulates purposeful behavior. New technology and neural sensors allow investigators to monitor in real-time the activity of two phenotype-specific juxtapositioned brain cells. We will monitor neural activity during sleep to determine activity of local circuits in normal versus diseased conditions.

PI_NAMEs: SHIROMANI, PRIYATTAM J. (contact)

PROGRAM_OFFICER_NAME: MACKIEWICZ, MIROSLAW

PROJECT_TERMS: Acetylcholine;Alzheimer's Disease;Alzheimer's disease model;Animal Model;Area;Arousal;awake;Behavior;Binding;Brain;brain cell;Brain Diseases;Brain imaging;Budgets;Calcium;calcium indicator;Cells;Color;Cre driver;Data;design;Disease;disease model;Disease Progression;Dopamine;falls;Female;Fluorescence;Funding;gamma-Aminobutyric Acid;Goals;Histamine;hypocretin;Hypothalamic structure;Image;imaging approach;Lateral;male;Methods;microendoscopy;Monitor;mouse model;Mus;network models;neural;neuronal patterning;Neurons;Neurosciences;new technology;non rapid eye movement;Norepinephrine;Pattern;Phenotype;Population;Positioning Attribute;promoter;redshift;REM Sleep;Research Personnel;response;sensor;Serotonin;Sleep;Sleep Deprivation;Sleep disturbances;Technical Expertise;Testing;Time;virtual;zona incerta

PROJECT_TITLE: Neuronal Activity in Sleep & Wake in Alzheimer's Disease Mice

STUDY_SECTION: BNRS

STUDY_SECTION_NAME: Behavioral Neuroendocrinology, Neuroimmunology, Rhythms, and Sleep Study Section [BNRS]


PROJECT_TERMS: Address;Area;Award;Breast Cancer therapy;clinical translation;Collaborations;Creativeness;Data;Extramural Activities;Funding;Future;Goals;Grant;high reward;high risk;innovation;Institution;interest;Joints;Modeling;Nature;new technology;novel;novel strategies;parent project;Pathway Analysis;Pilot Projects;programs;Publications;Recommendation;Research;Research Personnel;Science;Site;Source;Structure;System;Technology;United States National Institutes of Health;Vision

PROJECT_TITLE: Pilot Projects and Trans-Network Activities Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Lewy Body Dementia;Mental Health;Neurodegenerative;Neurosciences;Prevention;Sleep Research

ORG_CITY: MINNEAPOLIS

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative It is uncertain whether serotonergic REM sleep Behavior Disorder (5-HT RBD), like isolated RBD, is a prodromal syndrome of Dementia with Lewy bodies. This project will test for the presence of abnormally phosphorylated alpha-synuclein aggregates on targeted skin biopsy in 5-HT RBD compared to matched controls. Additionally, we will prospectively explore for brainstem neurodegeneration, segment and parcellate pontine regions that control REM sleep as well as evaluate for speech deficits consistent with Lewy body pathology.

PI_NAMEs: HOWELL, MICHAEL J (contact)

PROJECT_TERMS: Affect;alpha synuclein;Alzheimer's disease related dementia;anti-depressive agents;Biological Markers;biomarker identification;Brain Stem;Central Nervous System;Clinical;Clinical Research;Clinical Trials;Cognitive;cognitive testing;cohort;Color Visions;comparison control;Complex;Cutaneous;Data;demented;Dementia with Lewy Bodies;Deposition;detection sensitivity;Development;Disease;Disease Progression;Dreams;Early Diagnosis;Early identification;Evaluation;experience;Goals;Histopathology;Impaired cognition;Impairment;Individual;insight;Investigation;Lesion;Lewy Bodies;Lewy Body Disease;Lewy body pathology;Magnetic Resonance;Magnetic Resonance Imaging;Masks;method development;Methods;mild cognitive impairment;Motor;motor deficit;multimodality;Multiple System Atrophy;National Institute on Aging;Natural History;Nerve Degeneration;Nerve Fibers;Neurodegenerative Disorders;neuroimaging;Neurologic Dysfunctions;neuromelanin;Neuronal Plasticity;Neurons;neuroprotection;older adult;Paralysed;Parkinson Disease;Participant;Pathologic;Pathology;Patients;Peripheral Nervous System;Persons;Phosphorylation;Physiological;Pontine structure;prevent;prospective;Prospective Studies;rapid eye movement;REM Sleep;REM Sleep Behavior Disorder;Research;Selective Serotonin Reuptake Inhibitor;Serotonin;Severities;Signal Transduction;Skeletal Muscle;skin biopsy;Somatotype;Speech;Speed;Structure;Symptoms;Syndrome;synucleinopathy;Techniques;technology development;Testing;Therapeutic Trials;therapy development;Toxic effect;Violence;Work

PROJECT_TITLE: Identification of Prodromal Neurodegeneration in Serotonergic-Induced REM sleep Behavior Disorder

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Sleep Research;Urologic Diseases

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Nocturia (waking to pass urine during the main sleep period) occurs two or more times per night in nearly 50% of older adults and is among the most bothersome urinary symptoms, due to its potentially severe impact on sleep. However, nocturia in older adults is often viewed solely as a urological condition even though it is also a sleep condition since it involves disturbances of the “main sleep period.” The overall objective of the proposed project is to determine whether a coordinated, integrated non-pharmacological, non-surgical treatment that simultaneously addresses both the urological and insomnia factors contributing to nocturia is efficacious for improving nocturia, sleep, and daytime function.

PI_NAMEs: FUNG, CONSTANCE ;VAUGHAN, ELIZABETH CAMILLE (contact)

PROJECT_TERMS: Address;Adult;Affect;Aftercare;aged;antidiuretic;Beds;Behavior;Behavior Therapy;Behavioral;Bladder;Clinical Trials;Cognitive;Cognitive Therapy;Collaborations;comparison control;Conditioned Reflex;conditioning;Consent;Delirium;Education;Effectiveness;efficacy evaluation;Exercise;falls;follow-up;Frequencies;functional improvement;Goals;Grant;Habits;Health education;Health Services Research;improved;Increased frequency of micturition;indexing;Life Style;Liquid substance;medical specialties;Multicenter Trials;Napping;Nocturia;novel;older adult;Participant;Patient Self-Report;Pelvic Floor Muscle;Personal Satisfaction;Pharmaceutical Preparations;Pharmacological Treatment;Pittsburgh Sleep Quality Index;Positioning Attribute;Procedures;programs;Prostate;Quality of life;Randomized;randomized trial;Relaxation;Reporting;Research;Research Personnel;Risk;Safety;Severities;side effect;Site;Sleep;Sleep disturbances;sleep onset;sleep quality;Sleeplessness;Symptoms;Thinking;Time;Training;treatment program;Treatment Protocols;treatment strategy;urinary;Urine;urologic;Wakefulness

PROJECT_TITLE: A multi-center trial to improve nocturia and sleep in older adults

STUDY_SECTION: ASG

STUDY_SECTION_NAME: Aging Systems and Geriatrics Study Section[ASG]


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Genetics;Human Genome;Immunotherapy;Neurosciences;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Glioblastoma multiforme, a common and highly aggressive form of brain cancer with a universally fatal outcome, is characterized by a vast degree of heterogeneity and an immune-suppressive tumor microenvironment driven by cancer stem cells. Our preliminary results show that glioma cancer stem cells activate cell-intrinsic mechanisms to drive and maintain a unique, immunosuppressive cell phenotype and suggest that targeting immunosuppressive GBM cells will boost the anti-tumor immune response. Favorable results from this proposal will provide a rationale for combining therapeutics directed at immunosuppressive GBM cells with other immunotherapies (e.g. checkpoint inhibitors, CAR-T cells, vaccines) to treat brain tumors.

PI_NAMEs: JOHNSON, AMANDA  (contact)

PROGRAM_OFFICER_NAME: ELJANNE, MARIAM

PROJECT_TERMS: Adult;Allografting;anti-tumor immune response;Attenuated;Automobile Driving;Behavior;Bioinformatics;Biological Assay;Biological Models;Brain Neoplasms;cancer stem cell;cell dedifferentiation;Cell model;Cell Physiology;Cell Survival;Cells;Characteristics;checkpoint therapy;chimeric antigen receptor T cells;Clinical;clinical translation;Clonal Evolution;Coculture Techniques;Data;Dedications;Dependence;Development;effective therapy;Endowment;Environment;Event;Fatal Outcome;Gene Expression Profile;Genetic;Glioblastoma;Glioma;Goals;Grant;Growth;Heterogeneity;Hypoxia;Immune;immune cell infiltrate;Immune checkpoint inhibitor;Immune Evasion;Immune response;Immune Targeting;Immunocompetent;Immunosuppression;Immunotherapeutic agent;Immunotherapy;improved;In Vitro;in vivo;inhibitor;interdisciplinary approach;Interdisciplinary Study;knock-down;Maintenance;Malignant neoplasm of brain;Malignant Neoplasms;Mesenchymal;Metabolic;metabolic profile;metabolomics;Methods;Modeling;Molecular;molecular subtypes;Mus;neoplastic cell;novel;novel strategies;novel therapeutics;Nutrient;Oncogenic;Patients;Pharmaceutical Preparations;pharmacologic;Phase;Phenotype;Population;pre-clinical;pressure;Prognosis;programs;Receptor Inhibition;Receptor Signaling;Regulatory T-Lymphocyte;Research;Resistance;response;self-renewal;Signal Induction;Signal Transduction;single cell sequencing;single-cell RNA sequencing;small hairpin RNA;small molecule;small molecule inhibitor;Specimen;stem;stem cell biology;stem cell function;stem cells;stem-like cell;T-Lymphocyte;targeted treatment;Techniques;Technology;TGFBR2 gene;Therapeutic;therapeutic target;therapy resistant;Tissues;Training;trait;transcription factor;transcriptional reprogramming;transcriptome sequencing;transcriptomics;Transgenic Organisms;translatable strategy;tumor;tumor growth;tumor heterogeneity;Tumor Immunity;tumor microenvironment;tumor progression;Tumor Promotion;Tumor-infiltrating immune cells;Vaccines

PROJECT_TITLE: Dissecting the tumor cell-immune TME axis to identify therapeutically actionable vulnerabilities that potentiate immunotherapy in GBM


ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Project Narrative Some individuals immunized with the otherwise very effective Streptococcus pneumoniae capsule polysaccharide vaccines experience breakthrough infections caused by serotypes included in the vaccine. To investigate why these cases of “vaccine failure” occur, we will re- evaluate the vaccine serotypes most associated with vaccine failure, i.e., 19A/19F, for the presence of capsule variants too alike to be distinguished from 19A/19F, but distinct enough to evade vaccine-induced immunity. Understanding how the natural malleability of bacterial capsules limits the effectiveness of immunization is key for the smart design of future vaccines.

PI_NAMEs: NAHM, MOON H. (contact)

PROGRAM_OFFICER_NAME: GU, XIN-XING

PROJECT_TITLE: Serogroup 19 capsule maleability leading to vaccine failure

STUDY_SECTION: BV

STUDY_SECTION_NAME: Bacterial Virulence Study Section [BV]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Infectious Diseases;Microbiome

ORG_CITY: NEW HAVEN

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PUBLIC HEALTH RELEVANCE Campylobacter jejuni is the most common cause of food-born diarrhea in the United States exceeding the number of cases of Salmonella spp., Shigella spp., or Escherichia coli O157:H7. The resident intestinal microbiota has emerged as a formidable barrier that prevents pathogen colonization. Therefore, the study of the mechanisms by which the resident microbiota can restrict C. jejuni colonization of the intestinal tract is of great Public Health significance and may lead to novel strategies to control C. jejuni infections.

PI_NAMEs: GALAN, JORGE E (contact)

PROGRAM_OFFICER_NAME: BAQAR, SHAHIDA

PROJECT_TERMS: Animal Model;Animals;Antibiotics;base;Birds;Campylobacter jejuni;Chicken Model;Chickens;Clinical;Collection;combat;Communities;Complication;cost;Data;Development;Diarrhea;diarrheal disease;Disease Outbreaks;Domestic Animals;Domestic Fowls;dysbiosis;enteric pathogen;Escherichia coli O157:H7;experimental study;Farm;Food Chain;Food Industry;foodborne;foodborne illness;Foundations;Genes;Genetic Screening;Germ-Free;Growth;Guillain Barré Syndrome;gut colonization;gut inflammation;gut microbiota;healthy volunteer;Human;immunological status;In Vitro;Individual;Infection;insight;Intestines;Laboratories;Mediating;microbial community;microbial composition;microbiota;Modeling;Nerve Degeneration;novel strategies;pathogen;pathogenic bacteria;Pathogenicity;Pathology;Patients;permissiveness;Phenotype;Physiological;Predisposition;prevent;Public Health;public health relevance;Reporting;Resistance;Role;rRNA Genes;Salmonella;Salmonella enteritidis;Salmonella typhimurium;Sampling;Shigella;Source;stool sample;Symptoms;United States;Virulence Factors;Wild Animals;Work

PROJECT_TITLE: Campylobacter jejuni restriction by the intestinal microbiota

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IMII-U(01)]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Cancer Genomics;Genetics;Human Genome;Immunotherapy;Obesity;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Women's Health Research

ORG_CITY: WASHINGTON

ORG_NAME: GEORGETOWN UNIVERSITY

ORG_STATE: DC

PHR: Therapy resistance is a major challenge to the development of effective cancer treatment, therefore, the long- term goal of both the F99 and K00 phases of this work is to elucidate the molecular mechanisms underlying therapy resistance. My thesis work identified that p27 can transcriptionally co-regulate STAT3 to activate a gene programs driving cancer stem cell expansion. In this F99, I will investigate if p27 cooperates with STAT3 to promote tumor immune evasion by re-shaping the TME, and the K00 will elucidate if p27 promotes chronic inflammation in obesity by coactivating ER/NFB/STAT3 to increase immune evasion and endocrine therapy resistance in ER+ BC and further test if endocrine blockade/checkpoint inhibitor (anti-PD1) combinational therapy would be beneficial in obese breast cancer.

PI_NAMEs: RAZAVIPOUR, SEYEDEHFATEMEH  (contact)

PROJECT_TERMS: Address;Adipocytes;Affect;ANGPTL4 gene;anti-PD-1;ATAC-seq;Automobile Driving;Biological Assay;Biological Response Modifiers;Blood;breast cancer metastasis;Breast Cancer Risk Factor;C-terminal;cancer cell;Cancer Etiology;cancer recurrence;Cancer Research Project;cancer stem cell;cancer therapy;CCL2 gene;CD8-Positive T-Lymphocytes;Cell Cycle;Cell Cycle Inhibition;Cells;chemotherapy;ChIP-seq;Chromatin;Chronic;Combined Modality Therapy;cytokine;Development;diet-induced obesity;Doctor of Philosophy;Drug resistance;effective therapy;embryonic stem cell;Endocrine;Environment;Estrogen Receptors;Flow Cytometry;Gene Expression;Genes;Genetic Transcription;Goals;Grant;High Fat Diet;hormone therapy;Human;IL6 gene;Immune;immune cell infiltrate;Immune checkpoint inhibitor;Immune Evasion;Immunologist;Immunology;immunoregulation;Immunotherapeutic agent;in vivo;Infiltration;Inflammation;Inflammation Mediators;Inflammatory;inhibitor;Interleukin-6;Investigation;knock-down;Link;Macrophage;Malignant Breast Neoplasm;Malignant Neoplasms;Mass Spectrum Analysis;Mediating;Methods;mimetics;Molecular;Molecular Biology;mortality;Mus;Natural Killer Cells;Neoplasm Metastasis;neoplastic cell;novel;Obese Mice;obese person;Obesity;Oncogenes;Oncogenic;p65;Paper;Pathway interactions;peripheral blood;permissiveness;Persons;Phase;Phosphorylation;Phosphotransferases;PIK3CG gene;Play;Postdoctoral Fellow;pre-doctoral;Prevalence;prevent;programmed cell death ligand 1;programs;promoter;Property;recruit;Regulatory T-Lymphocyte;RELA gene;Research;Research Methodology;Research Personnel;Research Project Grants;Resistance;Role;self-renewal;Shapes;single-cell RNA sequencing;STAT3 gene;stem cell expansion;stem cells;targeted treatment;Testing;therapy resistant;Thinness;Training;training opportunity;transcription factor;transcriptome sequencing;tumor;Tumor Escape;tumor immunology;tumor initiation;tumor microenvironment;Tumor Promotion;Tumor Suppressor Proteins;VEGFA gene;Woman;Women's mortality;Work

PROJECT_TITLE: p27pTpT drives cancer-promoting inflammation and shapes the tumor microenvironment (TME) toward a more tumor-permissive state in vivo


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Depression;HIV/AIDS;Infectious Diseases;Mental Health;Mental Illness;Prevention

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it is aimed at informing methods of increasing access to quality mental healthcare among people with HIV, which is hypothesized to improve both mental health and HIV outcomes. The findings are expected to enhance HIV treatment efforts in under-resourced settings worldwide. The proposed research is directly relevant to NIH HIV/AIDS Research Priorities on addressing HIV-associated comorbidities, including mental illness, as well as with its strategic goal of improving treatment outcomes among persons with HIV.

PI_NAMEs: HOOK, KIMBERLY MICHELLE (contact)

PROGRAM_OFFICER_NAME: SENN, THERESA ELAINE

PROJECT_TERMS: Address;Adherence;Adult;Adverse effects;Affect;Aftercare;antiretroviral therapy;Anxiety;Area;attentional control;Behavioral;biological sex;Birth;Caring;Clinic;clinically relevant;Cognitive Therapy;Collaborations;common symptom;common treatment;Communities;comorbidity;Conflict (Psychology);contextual factors;Continuity of Patient Care;Country;Data;Data Analyses;depressive symptoms;design;Diagnostic;Eastern Europe;efficacy study;Elements;Epidemic;European;evidence base;Evidence based intervention;Evidence based treatment;experience;follow-up;Genetic Complementation Test;Goals;Health Personnel;HIV;HIV Infections;HIV/AIDS;Impairment;improved;Incidence;Income;innovation;interest;Intervention;Interview;Knowledge;Learning;Life;Link;Mediating;Mediation;Mediator;Mental Depression;Mental disorders;Mental Health;Mental Health Services;Mentored Patient-Oriented Research Career Development Award;Mentorship;Methods;Nurses;Outcome;Pathway interactions;Persons;Physicians;Population;post-traumatic stress;primary outcome;Protocols documentation;psychologic;Psychologist;Public Health;Publications;Randomized;randomized, clinical trials;reduce symptoms;Reporting;Research;Research Priority;Resources;Sampling;satisfaction;secondary outcome;sex assigned;Site;Testing;therapy adherence;Training;Treatment outcome;Ukraine;United States National Institutes of Health;Viral;War

PROJECT_TITLE: Implementing Evidence-Based Treatment for Common Mental Disorders in HIV Clinics in Ukraine

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


ORG_CITY: WINSTON-SALEM

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

ORG_STATE: NC

PHR: In anticipation of the needs of the growing number of older adults, the WF OAIC will identify and evaluate novel strategies to prevent physical disability and return disabled older adults to independence using its highly integrated translational research and training infrastructure.

PI_NAMEs: KRITCHEVSKY, STEPHEN B. (contact)

PROGRAM_OFFICER_NAME: SERRA, MONICA CHRISTINE

PROJECT_TERMS: Achievement;Address;Adipose tissue;Affect;age related;age related biomarkers;age related decline;Aging;aging biomarker;aging brain;aging population;American;Animal Model;Behavioral Sciences;bioimaging;Biological Markers;Biology;Biology of Aging;Biometry;Body Composition;Body Weight decreased;bone preservation;bone strength;Brain;Caloric Restriction;Capsicum;career;Central Nervous System;Clinical;Clinical Data;clinical implementation;Clinical Research;Cognitive Science;Communities;comorbidity;Dancing;Dedications;disability;Disability prevention;disability risk;Disability treatment;disabled;Disease;early-career faculty;education research;EFRAC;energy balance;Environment;Epidemiology;exercise intervention;exosome;Faculty;Funding;Future;Genomics;Health;Health Promotion;Health system;Heart Atrium;Heart failure;Hospitals;Human;image processing;imaging modality;implementation strategy;improved;improvement on sleep;Information Systems;Infrastructure;innovation;insight;Intervention;K-Series Research Career Programs;Knee Osteoarthritis;Leadership;Learning;Measures;Medicine;Mentors;Metformin;mHealth;MicroRNAs;Mission;Modeling;Monitor;multidisciplinary;Muscle;next generation;nonhuman primate;novel;novel strategies;Obesity;older adult;older patient;Ophthalmology;Pathway interactions;Phenotype;Physical Function;physically handicapped;Pilot Projects;Population;population based;preservation;prevent;Productivity;programs;Radiology Specialty;Rehabilitation therapy;remote intervention;Research;Research Activity;research and development;Research Infrastructure;Research Personnel;Research Support;Resources;Scientist;senolytics;Services;Signal Transduction;skeletal;sleep quality;Social Work;socioeconomics;success;System;Testing;Time-restricted feeding;tool;Training;Training and Infrastructure;Translating;translational approach;translational impact;translational pipeline;Translational Research;Translations;Vision;walking program

PROJECT_TITLE: Wake Forest Claude D. Pepper OAIC - Renewal


NIH_SPENDING_CATS: Aging;Disability Research

PROJECT_TERMS: Achievement;Acquired Immunodeficiency Syndrome;Advisory Committees;Advocate;Affect;Aging;Alzheimer disease prevention;American;Basic Science;Biology of Aging;Capsicum;clinical care;Clinical Research;Communities;Conduct Clinical Trials;COVID-19 pandemic;design;Development;Disability prevention;Disability treatment;early-career faculty;education research;Ensure;Environment;experience;Faculty;Fostering;Geriatrics;Gerontology;Geroscience;Goals;Guidelines;Health;Health system;healthy aging;Heart Atrium;HIV;innovation;insight;Institution;Interdisciplinary Study;Investments;Leadership;leadership development;medical schools;Mission;Modeling;Monitor;Multicenter Studies;multidisciplinary;Neurosciences;novel strategies;older adult;operation;Outcome;participant safety;Pathway interactions;Personal Satisfaction;Persons;Phase;Physical Function;Policies;Positioning Attribute;Productivity;programs;prototype;Regulation;Reporting;Research;research and development;Research Personnel;Research Support;Resources;responsible research conduct;Scientist;Secure;Services;success;synergism;Testing;Translating;Translational Research;Translations;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Leadership and Administrative Core


ADMINISTERING_IC: NR

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Palliative Care;Social Determinants of Health

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative Dignified and compassionate end-of-life (EOL) care is a cornerstone of high-quality, patient-centered care, but in safety-net hospitals EOL care is often overlooked, considered too late, or not at all. By eliciting and implementing final wishes for dying patients, the 3 Wishes Project (3WP) has demonstrated, in tertiary academic centers, that acts of compassion can improve the EOL experience and help families cope with loss. We propose to implement the 3WP in safety-net hospitals where there are less resources and more diverse, disadvantaged patient populations, and hypothesize that there will be similar positive effects on the EOL experience for patients, families, and clinicians.

PI_NAMEs: NEVILLE, THANH H (contact)

PROGRAM_OFFICER_NAME: AKUBU-ODERO, MAUREEN KALAMBU

PROJECT_TERMS: Address;Adoption;advanced disease;Bereavement;Budgets;burnout;Caring;Cessation of life;Clinical;Collaborations;Compassion;Consolidated Framework for Implementation Research;coping;cost;County;Critical Illness;Data;design;Direct Costs;Disadvantaged;Distress;distrust;Effectiveness;effectiveness/implementation study;Elements;Emotional;Empathy;empowerment;end of life;end of life care;Evaluation;experience;Family;Family member;Foundations;Grief reaction;Health;health care settings;Health Services;Health Services Accessibility;Healthcare;Hospitalization;Hospitals;implementation barriers;implementation outcomes;implementation process;implementation science;implementation strategy;implementation/effectiveness;improved;Inequity;innovation;Intensive Care Units;Intervention;Interview;Job Satisfaction;Language;Leadership;Life Experience;Limited English Proficiency;Los Angeles;loved ones;low health literacy;Low income;Measurement;Measures;Medical;Medicine;Mental Depression;Methods;Modeling;Multi-Institutional Clinical Trial;Music;neglect;novel;Nurses;Palliative Care;patient oriented;patient population;Patient-Centered Care;Patients;Patients' Rooms;Perception;Physicians;Play;Population;Post-Traumatic Stress Disorders;primary outcome;psychological symptom;Public Hospitals;Qualitative Research;Quality of life;Randomized;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Research;Research Design;Resource-limited setting;Resources;safety net;Sampling;satisfaction;Scientist;secondary outcome;Services;Spirituality;structural determinants;Structure;Survey Methodology;Surveys;System;Thinness;tool;Training;treatment as usual;Uninsured;Variant;Work

PROJECT_TITLE: Personalized End of Life Care in Safety-Net hospitals: Implementation of the 3 Wishes Project

STUDY_SECTION: ICSC

STUDY_SECTION_NAME: Interdisciplinary Clinical Care in Specialty Care Settings Study Section[ICSC]


PI_NAMEs: NICKLAS, BARBARA J (contact)

PROJECT_TERMS: Acute;Address;Affect;age related;Aging;aging related;American;Beavers;behavioral outcome;bioimaging;Biological;Biology;Biometry;Body Composition;Capsicum;career;career development;Certification;Clinical;clinical center;clinical practice;Clinical Research;clinically relevant;Collaborations;Communities;COVID-19 pandemic;design;Development;dietary;disability;Disability prevention;Disability treatment;early-career faculty;education research;Electronic Health Record;Ensure;experimental study;Fatigue;Fostering;frailty;Functional disorder;functional independence;functional status;Funding;Goals;Grant;Health;Health Status;Health system;Healthcare Systems;Heart Atrium;Human;improved;Information Systems;Infrastructure;innovation;Institution;Intervention;Intervention Studies;investigator training;Leadership;Learning;low socioeconomic status;Measurement;Measures;Medical;medical schools;Mentors;Monitor;Multicenter Trials;multiple chronic conditions;novel strategies;Observational Study;older adult;Outcome Measure;Pain;Participant;participant retention;Pathway interactions;Patient Care;Patient Recruitments;Phenotype;Physical Function;physically handicapped;Pilot Projects;Positioning Attribute;pragmatic trial;preservation;programs;Progress Reports;Publications;remote patient monitoring;Research;research and development;Research Design;Research Methodology;Research Personnel;research study;Research Support;Resources;response;Role;Safety;Self Assessment;Site;sleep behavior;Standardization;Target Populations;Testing;Translational Research;Translations;Universities;Visit;Work

PROJECT_TITLE: Clinical Research Core


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Cancer;Digestive Diseases;Genetics;Neurosciences;Pancreatic Cancer;Rare Diseases

ORG_CITY: TUCSON

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: PROJECT NARRATIVE Gastroenteropancreatic neuroendocrine tumors are a complex group of malignancies that are increasing in diagnoses and present with limited options for screening and treatment. This proposal aims to define the cells- of-origin for these cancers and target a specific signaling pathway with the potential for therapeutic benefit. Identifying the origins and pathways that support neuroendocrine tumor development is critical for developing personalized molecular biomarkers and novel therapeutic approaches that will ultimately lead to improved patient outcomes.

PI_NAMEs: DUAN, SUZANN  (contact)

PROGRAM_OFFICER_NAME: SASLOWSKY, DAVID E

PROJECT_TERMS: 3-Dimensional;Address;Arizona;Automobile Driving;Award;Awareness;Biology;career;career development;Cell Line;Cell Reprogramming;Cells;Cellular biology;Clinic;Complex;Data Analyses;defined contribution;Development;Development Plans;Diagnosis;Dimensions;Duodenum;Endocrine;Enteral;Environment;Erinaceidae;Event;experience;Faculty;gastroenteropancreatic neuroendocrine tumor;gastrointestinal;Gastrointestinal Physiology;Gene Deletion;Genes;genomic data;Glial Fibrillary Acidic Protein;Goals;Growth;Hormones;Human;human model;Hyperplasia;improved;Incidence;Inherited;inhibitor;innovation;Islet Cell Tumor;knock-down;Knowledge;Malignant Neoplasms;Mediating;MEN1 gene;Menin;Mentored Research Scientist Development Award;Mentors;Mentorship;Methods;Modeling;Molecular;Molecular Biology;molecular marker;mouse model;Mus;Mutation;Neoplasms;Neoplastic Cell Transformation;neural;Neural Crest;Neural Crest Cell;Neuroendocrine Cell;neuroendocrine differentiation;neuroendocrine phenotype;Neuroendocrine Tumors;Neurosecretory Systems;novel;novel therapeutic intervention;Organoids;overexpression;Pancreas;Paraffin Embedding;Pathogenesis;Pathway interactions;Patient-Focused Outcomes;Pattern;personalized approach;pharmacologic;Phenotype;Pituitary Gland;Population;Prevalence;Productivity;programs;Regulation;Reporter;Research;research facility;Research Personnel;Research Project Grants;Resource Development;restraint;Role;screening;SHH gene;Signal Pathway;Signal Transduction;single cell analysis;skills;smoothened signaling pathway;specific biomarkers;Stomach;Syndrome;System;targeted treatment;Therapeutic;Time;Tissue Culture Techniques;Tissues;Training;transcriptomic profiling;transcriptomics;Transgenes;Transgenic Mice;Transgenic Organisms;tumor;Tumor Burden;tumor initiation;Tumor Suppressor Proteins;tumorigenic;Universities;Work;Xenograft procedure

PROJECT_TITLE: The role of Hedgehog and enteric neural crest cell reprogramming in neuroendocrine differentiation

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


PI_NAMEs: JUSTICE, JAMIE NICOLE (contact)

PROJECT_TERMS: Adipose tissue;Affect;Affinity;age related;Aging;aging related;American;Ancillary Study;Animal Model;Animals;biobank;bioimaging;Bioinformatics;Biological;Biological Aging;Biological Assay;Biological Factors;Biological Markers;Biological Process;Biological Testing;Biology;Blood;Capsicum;career;catalyst;Cell Aging;Cells;Clinical Sciences;Collaborations;Collection;Consultations;data repository;Development;disability;Disability prevention;Disability treatment;DNA Methylation;early-career faculty;Education;Educational workshop;Faculty;faculty support;functional decline;functional disability;Funding;Gene Expression;Geroscience;Goals;Human;human tissue;In Vitro;Inflammation;innovation;Institution;instrument;Interdisciplinary Study;Internships;Journals;Justice;Knowledge;Laboratories;Leadership;leadership development;loss of function;Measures;medical schools;meetings;Mentors;Mentorship;metabolomics;Methodology;Methods;microbiome;Mission;Mitochondria;Modification;Molecular;Muscle;new technology;novel;novel strategies;Organ;Outcome;oxidative damage;Pathway interactions;Physical Function;Pilot Projects;Play;pre-clinical;Procedures;Process;Productivity;Program Development;Proteomics;Protocols documentation;repository;Research;Research Personnel;Resources;Retrieval;Role;Services;Skeletal Muscle;skeletal tissue;Specimen;symposium;System;Techniques;Technology;Testing;Therapeutic;therapeutic target;Tissues;Translating;Translational Research;Universities;Urine;Work

PROJECT_TITLE: Integrative Biology Core


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Chronic Liver Disease and Cirrhosis;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Liver Disease;Machine Learning and Artificial Intelligence;Microbiome;Physical Activity;Prevention;Sarcopenia

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

PHR: PROJECT NARRATIVE Exercise training is recommended to reverse sarcopenia and physical frailty in cirrhosis but the mechanistic responses have not been evaluated. The proposed clinical trial will dissect the molecular, metabolic and functional responses to 12-weeks of home-based, telemedicine-supervised endurance or resistance training compared to standard of care recommendations in patients with liver cirrhosis. Multiomics data including changes in the gut microbiome/xenometabolites in response to exercise will be evaluated using machine learning approaches to personalize training recommendations in cirrhosis.

PI_NAMEs: DASARATHY, SRINIVASAN  (contact)

PROGRAM_OFFICER_NAME: SHERKER, AVERELL H

PROJECT_TERMS: Address;Adherence;Ammonia;Artificial Intelligence;ATP Synthesis Pathway;Autophagocytosis;Chronic Disease;Cirrhosis;Clinical;Clinical Trials;Data;Disease;efficacy evaluation;endurance exercise;Evaluation;Exercise;exercise capacity;exercise prescription;exercise program;exercise training;Fatigue;fecal microbiome;Feces;Foundations;frailty;Free Radicals;Future;Generations;Global Change;Goals;gut dysbiosis;gut microbiome;Hepatic;Home;Hospitalization;Human;Hyperammonemia;Impairment;improved;innovation;Kinetics;Liver Cirrhosis;Liver diseases;Machine Learning;machine learning algorithm;Measures;Mediator;Metabolic;Metabolism;metabolome;metabolomics;Methods;microbial;microbiome;microbiome research;Mission;Mitochondria;mitochondrial oxidative dysfunction;Molecular;mortality;Multicenter Studies;Multiomic Data;multiple omics;Muscle;muscle form;Muscle Mitochondria;Muscle Proteins;muscle strength;Muscular Atrophy;National Institute of Diabetes and Digestive and Kidney Diseases;Outcome;Oxygen Consumption;Patients;Phosphorylation;Plasma;Pre-Clinical Model;programs;prospective;Protein Biosynthesis;Proteome;Proteomics;proteostasis;Protocols documentation;Publishing;Randomized;Recommendation;reduced muscle mass;reduced muscle strength;Reporting;resistance exercise;response;Safety;sarcopenia;Signal Transduction;Skeletal Muscle;skeletal muscle wasting;standard of care;Structure;Systems Biology;Telemedicine;Testing;Tissues;Tracer;Training;Training Programs;transcriptome;transcriptomics;Translating;VO2max

PROJECT_TITLE: Mechanistic basis of exercise responses in liver disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-KUDS-A(04)]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Mental Health;Mental Illness;Post-Traumatic Stress Disorder (PTSD);Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

ORG_CITY: RICHMOND

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: Project Narrative  Alcohol use disorder (AUD) and posttraumatic stress disorder (PTSD) commonly co-occur and are likely to increase in prevalence following the COVID-19 pandemic given the vast health, psychiatric, and economic toll this pandemic is causing particularly among persons of color. Understanding risk and protective factors for AUD and PTSD is critical to inform effective prevention and intervention planning; these conditions have shared latent genetic risk as well as a molecular genetic correlation, and the onset of one condition may increase risk for development of the other condition and thus multi-method studies that integrate shared genetic and phenotypic risk are needed. The present study will conduct a multi-method investigation of PTSD and AUD among a highly trauma-exposed at-risk population of inner-city residents for whom the COVID-19 pandemic may be particularly impactful for to rigorously test models of comorbidity thereby shedding light on these important public health phenotypes.

PI_NAMEs: AMSTADTER, ANANDA B (contact);LOTT, ABIGAIL POWERS

PROGRAM_OFFICER_NAME: ZHA, WENXING

PROJECT_TERMS: Accounting;Acute;Address;Affect;Alcohol consumption;Alcohol Phenotype;alcohol risk;alcohol use disorder;Area;binge drinking;Black Populations;Clinical;comorbidity;Consumption;COVID-19 pandemic;craving;Data;design;Development;Diagnostic;Disease;Disparity;disparity gap;Dropout;Ecological momentary assessment;Economics;Enrollment;Equation;Equity;Etiology;Financial Hardship;follow up assessment;follow-up;Genetic;Genetic Research;Genetic Risk;Genetic study;genome wide association study;genome-wide analysis;Genomics;Goals;Health;Heritability;high risk;indexing;Individual;inner city;Intervention;Interview;Investigation;Knowledge;knowledge base;Lead;Light;longitudinal design;low socioeconomic status;Measurement;Measures;men;Mental Health;Methodology;Methods;Modeling;Molecular Genetics;novel;pandemic disease;Participant;Pathway interactions;Patient Recruitments;Patient Self-Report;people of color;Persons;Phenotype;polygenic risk score;Population;Populations at Risk;Post-Traumatic Stress Disorders;Predisposition;Prevalence;Prevention;Prevention program;Prognosis;prospective;protective factors;Protocols documentation;Public Health;racial discrimination;racial minority;racial minority population;Recording of previous events;Reduce health disparities;relapse risk;Research;Resources;Risk;Risk Behaviors;Risk Factors;risk sharing;saliva sample;Sampling;Self Medication;Series;Severities;sex;social;social health determinants;Social support;Specificity;Symptoms;Technology Assessment;Testing;Time;Trauma;trauma exposure;treatment program;Underrepresented Populations;Urban Community;Urban Population;Variant;Woman;Work

PROJECT_TITLE: Integrating genetic and ecological momentary assessment technologies to advance models of PTSD-AUD comorbidity

STUDY_SECTION: LHB

STUDY_SECTION_NAME: Lifestyle and Health Behaviors Study Section[LHB]


NIH_SPENDING_CATS: Aging;Bioengineering;Data Science;Disability Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention

PI_NAMEs: LENG, XIAOYAN  (contact)

PROJECT_TERMS: Abdomen;Acceleration;Affect;age related decline;Aging;aging related;American;analytical tool;Award;Biological;Biological Markers;Biometry;Brain;Capsicum;Clinical;Clinical Trials;Collaborations;complex data;Consult;Data;Data Analyses;data management;Data Management Resources;data reuse;Data Science;Data Sources;Decentralization;design;Development;Disability prevention;disability risk;Disability treatment;education research;Educational process of instructing;Educational workshop;Electronic Health Record;Environment;Evaluation;Evolution;Faculty;flexibility;frailty;Funding;Future;Geroscience;Goals;health equity promotion;Image;Individual;informatics tool;Information Systems;innovation;Lead;Leadership;Machine Learning;machine learning method;Measurement;medical schools;member;Mentors;Mentorship;Metadata;method development;Methods;Mission;Modeling;Monitor;Movement;next generation;novel;novel strategies;Observational Study;older adult;Outcome;Participant;Pathway interactions;Physical Function;physically handicapped;Pilot Projects;Play;pragmatic study;predictive modeling;Prevention;Productivity;Publications;Qualifying;Randomized;randomized trial;recruit;Reporting;Research;Research Design;Research Personnel;Research Project Grants;Research Support;Research Training;Resource Sharing;Role;Safety;Sample Size;Series;simulation;Statistical Data Interpretation;Statistical Methods;statistics;Structure;success;supervised learning;System;Testing;Thinking;Time;Training;Translating;Universities;Writing

PROJECT_TITLE: Biostatistics and Research Information Systems Core


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Genetics;Human Genome;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: The adrenal cortex is the major source of steroid hormones that drive a variety of critical physiologic functions. However, the molecular mechanisms driving human adrenal cortex development and steroid biosynthesis are poorly understood due to the paucity of appropriate model systems. Using our innovative inducible pluripotent stem cell-derived human fetal adrenal organoid system, we will identify cellular and signaling mechanisms and gene regulatory networks orchestrating human adrenocortical development and steroid biosynthesis to provide key insight into the pathophysiology of primary adrenal insufficiency and adrenal androgen excess and to serve as a stepping stone for eventual regenerative therapy for patients with a wide range of adrenal diseases.

PI_NAMEs: SASAKI, KOTARO  (contact)

PROGRAM_OFFICER_NAME: MALOZOWSKI, SAUL N

PROJECT_TERMS: Addison's disease;Adrenal Cortex;Adrenal Glands;Agonist;androgen excess;Automobile Driving;Biological Models;Candidate Disease Gene;capsule;Cell Line;Cells;Cleavage Under Targets and Release Using Nuclease;Coculture Techniques;Complex;Corticotropin;Corticotropin Receptors;Defect;Development;Disease;Dose;Elements;Embryo;Epithelium;Evaluation;Excision;Exhibits;experimental study;Exposure to;fetal;Functional disorder;Gene Dosage;Gene Expression;gene regulatory network;Genes;Heterozygote;Homeostasis;Hormone Responsive;Human;human induced pluripotent stem cells;in vivo;induced pluripotent stem cell;inhibitor;innovation;insight;Learning;Life;Ligands;loss of function;Mediating;Molecular;Mus;mutant;Mutation;Organoids;Patients;Peripheral;Physiological;preservation;Primordium;Process;progenitor;promoter;Proteins;regenerative therapy;response;reverse genetics;Rodent Model;Role;SHH gene;Signal Transduction;Signaling Molecule;single-cell RNA sequencing;Sorting;Source;Specific qualifier value;stem cell function;stem cell model;stem cells;Steroid biosynthesis;steroid hormone;Steroids;Supplementation;System;Testing;transcription factor;transcriptome sequencing;Up-Regulation;WNT Signaling Pathway;WNT4 gene

PROJECT_TITLE: Stem Cell-Based Models for Elucidating Human Adrenocortical Development and Dysfunction

STUDY_SECTION: CSME

STUDY_SECTION_NAME: Cell Signaling and Molecular Endocrinology Study Section[CSME]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Dementia;Disability Research;Neurodegenerative;Neurosciences;Nutrition;Osteoporosis;Prevention

PI_NAMEs: LENCHIK, LEON  (contact)

PROJECT_TERMS: Achievement;adipose imaging;Adipose tissue;Affect;Age;Aging;aging process;Alzheimer's Disease;American;Amyloid;Animals;Archives;Award;bariatric surgery;Beavers;bioimaging;Biological Markers;Biology of Aging;Biometry;bisphosphonate;Body Weight decreased;bone;Bone Density;bone health;bone loss;bone strength;Brain;brain health;Brain imaging;Capsicum;care delivery;career;clinical care;clinical phenotype;Clinical Research;Collaborations;Communities;Computed Tomography Scanners;cone-beam computed tomography;cortical bone;Data;data harmonization;Development;dietary;disability;Disability prevention;Disability treatment;Doctor of Philosophy;Elderly;Electronic Health Record;Ensure;Exercise;experience;Fatty acid glycerol esters;Funding;Goals;Health;Human;Image;image archival system;imaging biomarker;imaging capabilities;imaging facilities;imaging modality;Imaging Techniques;improved;Information Systems;Infrastructure;innovation;Institution;interest;Intervention;Intervention Studies;Leadership;Liquid substance;Machine Learning;Magnetic Resonance Imaging;Measures;Mentors;Methods;Mobility disability;Modeling;multidisciplinary;multimodality;Muscle;musculoskeletal imaging;novel;novel strategies;nutrition;Observation in research;older adult;Outcome;Paper;Pathway interactions;Peripheral;Phenotype;Physical Function;Pilot Projects;Positron-Emission Tomography;quantitative imaging;Radiologic Finding;Radiology Specialty;radiomics;Records;Research;research and development;Research Personnel;Research Project Grants;Resolution;Resources;Roentgen Rays;Scientist;Secondary to;Services;skills;strength training;Structure;substantia spongiosa;success;Testing;Training;Training and Education;Translating;ultrasound;United States National Institutes of Health;WFDC2 gene;whole body imaging;X-Ray Computed Tomography

PROJECT_TITLE: Bioimaging Resource Core


NIH_SPENDING_CATS: Aging;Genetics

ORG_CITY: WORCESTER

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

ORG_STATE: MA

PHR: Metabolic cycles provide building blocks and energy currency for the cell, but also signaling molecules that regulate diverse physiological responses from differentiation to aging. The metabolite S-adenosylmethionine (SAM) is one such factor that is used to regulate gene expression in the stress response, a key part of the aging process. We have discovered that individual SAM synthases has distinct effects and hypothesize that uncovering the mechanisms regulating local production of SAM will produce novel insights into stress-responses and aging.

PI_NAMEs: WALKER, AMY KAROL (contact)

PROGRAM_OFFICER_NAME: FU, YI-PING

PROJECT_TERMS: Adult;Affect;Aging;aging mechanism;aging process;Amino Acids;Animals;Automobile Driving;Biological;biological adaptation to stress;Biological Process;Biology;Caenorhabditis elegans;Carbon;Cell Nucleus;Cells;Chromatin;chromatin modification;Collaborations;Data;Development;dietary;Disease;DNA Methylation;Engineering;Environment;Enzymes;epigenetic regulation;Event;experimental study;Family;Gene Expression;Gene Expression Profile;Genes;Genetic Transcription;genome-wide;genomic locus;Germ Lines;Heat Stress;Heat-Shock Response;histone methylation;Individual;insight;Intestines;knock-down;Label;life span;Link;Liver;magnetic beads;Mammals;Masks;Metabolic;Metabolic Pathway;Metabolism;Methionine;Methylation;Methyltransferase;Modeling;Molecular;Mutation;Neurons;novel;Nucleotides;Pathway interactions;Phenotype;Phospholipids;Physiological;Polyamines;Production;promoter;Protein Isoforms;protein protein interaction;Proteins;Proteome;Proteomics;response;Ribosomes;RNA Interference;RNA methylation;Role;S-Adenosylhomocysteine;S-Adenosylmethionine;Signaling Molecule;Site;Source;Specificity;Stress;Subcutaneous Tissue;System;Testing;Therapeutic Intervention;Time;Tissues;transcriptome sequencing;Vitamin B 12;Vitamin B6

PROJECT_TITLE: Role of methylation-dependent pathways in aging and stress

STUDY_SECTION: CMAD

STUDY_SECTION_NAME: Cellular Mechanisms in Aging and Development Study Section[CMAD]


PI_NAMEs: KITZMAN, DALANE W (contact)

PROJECT_TERMS: Address;Affect;Aging;Area;Award;Basic Science;Brain;Capsicum;Cardiac rehabilitation;Cardiovascular Diseases;career;career development;Centers of Research Excellence;Clinical;Data;design;Development;Disability prevention;Disability treatment;Doctor of Philosophy;Education;education research;exercise program;exosome;experience;feasibility testing;Feedback;Funding;Goals;Grant;Growth;Heart failure;Home;improved;innovation;Institution;Interdisciplinary Study;Investments;K-Series Research Career Programs;Leadership;Mentors;Metformin;Mission;Mitochondria;Muscle;nonhuman primate;novel;novel strategies;older adult;older patient;Older Population;Pathway interactions;Patients;Peer Review;Physical Function;Physical Performance;physically handicapped;Pilot Projects;Procedures;Process;Productivity;programs;Publications;R24;recruit;Research;Research Design;Research Personnel;Research Project Grants;Research Proposals;research study;Resources;Rural;Science;skills;Speed;Study Section;success;symposium;Talents;Testing;Touch sensation;Translational Research;translational scientist;United States National Institutes of Health;Vision;Writing

PROJECT_TITLE: Pilot/Exploratory Studies Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: PROJECT NARRATIVE Mounting evidence from cryo-EM and mass spectrometry studies now strongly support tau modifications (PTMs), in particular tau acetylation, as mediators of neuronal dysfunction in a range of different human tauopathies including Alzheimer’s disease (AD). Our proposal will develop a new platform to dissect the signaling events that drive tau-mediated toxicity. In doing so, this study will 1) unravel a new modular pathway that impacts tau’s pathogenic properties, 2) provide a proof-of concept that multiple HDACs redundantly or synergistically target pathological tau, 3) link LRRK2 and other identified kinases to tau, thereby opening up future avenues for drug discovery targets to suppress tau-mediated toxicity.

PI_NAMEs: COHEN, TODD JONATHAN (contact);SANDERS, LAURIE H

PROGRAM_OFFICER_NAME: YANG, AUSTIN JYAN-YU

PROJECT_TERMS: Ablation;Acceleration;Acetylation;Acetyltransferase;Address;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Binding;Brain;Brain Pathology;Cell Physiology;Cognition;combinatorial;Coupled;CREBBP gene;Cryoelectron Microscopy;Cytoplasm;Data;Deacetylase;Deacetylation;Disease Progression;drug discovery;Engineering;Enzymes;Event;Functional disorder;Future;Genes;Genetic;Genetic Transcription;Goals;HDAC3 gene;HDAC4 gene;HDAC6 gene;Heart;Histone Deacetylase;Human;human induced pluripotent stem cells;Idiopathic Parkinson Disease;Impaired cognition;in vivo;Individual;Induced pluripotent stem cell derived neurons;innovation;Light;Link;LRRK2 gene;Lysine;Mass Spectrum Analysis;Measures;Mediating;Mediator;Microtubules;Modeling;Modification;mouse model;Mus;Nerve Degeneration;Neurodegenerative Disorders;Neuronal Dysfunction;Neurons;novel therapeutics;Nuclear;Parkinson Disease;Pathogenesis;Pathogenicity;Pathologic;Pathology;Pathway interactions;Phosphotransferases;Post-Translational Protein Processing;prevent;Process;Property;Role;Signal Pathway;Signal Transduction;Sirtuins;Structure;Synapses;synaptic function;synergism;tau aggregation;tau function;tau mutation;tau Proteins;tau-1;Tauopathies;Therapeutic;Toxic effect;upstream kinase;virtual

PROJECT_TITLE: Identifying kinase signaling pathways linked to tau-mediated neurodegeneration

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-NV-Q(02)M]


NIH_SPENDING_CATS: HIV/AIDS;Infectious Diseases

PHR: PROJECT NARRATIVE Broadly neutralizing antibodies (bnAbs) administered at antiretroviral therapy initiation have shown promise in reducing the HIV reservoir, boosting immune responses, and enhancing virus control. The extent of their activity and the mechanisms by which they work remain unclear. Here we will use a novel genetically barcoded mixed transmitted/founder SHIV/NHP model to determine the effects of bnAbs at antiretroviral therapy initiation on the reservoir, immune responses, and virus control, and then dissect the roles of bnAbs’ neutralizing and effector functions.

PI_NAMEs: BAR, KATHARINE JUNE (contact);PAIARDINI, MIRKO

PROGRAM_OFFICER_NAME: SANDERS, BRIGITTE E

PROJECT_TERMS: Acceleration;Aftercare;Animals;Antibodies;Antibody Response;Antibody Therapy;antiretroviral therapy;Autologous;Bar Codes;Binding;Biological Assay;Biological Models;Blood;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cells;Clinical;clinical development;Clinical Trials;disabled;Escape Mutant;experimental study;Genetic;Growth;High-Throughput Nucleotide Sequencing;HIV;HIV-1;Human;Immune response;Immunity;immunoregulation;Infusion procedures;Interruption;Kinetics;Measurable;Measures;Methods;Modeling;Molecular;neutralizing antibody;nonhuman primate;novel;Pathogenesis;Persons;Plasma;Polysaccharides;preclinical study;Property;Research;Resistance;response;Role;simian human immunodeficiency virus;System;T cell response;Testing;Time;Tissues;transmission process;treatment arm;treatment group;trial planning;Viral;viral rebound;Viral reservoir;Virus;Virus Activation;Virus Replication;Work

PROJECT_TITLE: Determining the effects of broadly neutralizing antibodies at antiretroviral therapy initiation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DCAI-E(02)]


PI_NAMEs: HOUSTON, DENISE KATHRYN (contact)

PROJECT_TERMS: Academic Career Award;Achievement;Affect;Age;age related;Aging;aging related;Alzheimer's disease related dementia;Applications Grants;Award;Beavers;Capsicum;career;career development;catalyst;Clinical Sciences;collaborative approach;Communication;Competence;Complement;deep learning;design;Development;Development Plans;disability;Disability prevention;Disability treatment;Discipline;Doctor of Philosophy;early-career faculty;Education;education research;Educational Curriculum;Educational Materials;Elderly;Elements;Environment;Ethics;Evaluation;experience;Exposure to;Faculty;Feedback;Financial Support;Fostering;functional decline;functional disability;Funding;Fundus;Geriatric Assessment;Geroscience;Glaucoma;Goals;Growth;improved;innovation;Institution;Interdisciplinary Study;Justice;K-Series Research Career Programs;Leadership;Managed Competition;meetings;member;Mentors;Mentorship;Mission;Monitor;multidisciplinary;next generation;novel strategies;Pathway interactions;Physical Function;Population;Positioning Attribute;Postdoctoral Fellow;preservation;prevent;Process;programs;recruit;Research;Research Design;research faculty;Research Personnel;Research Project Grants;Research Training;response;Scientist;Series;skill acquisition;skills;sound;success;Talents;Training;Training Activity;Training and Education;Training Programs;Translating;translational approach;translational pipeline;translational potential;Translational Research;Universities;virtual;Writing

PROJECT_TITLE: Research Education Component


ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Massachusetts Center for Alzheimer and dEmeNtia behaVIoral reSearch In minOrity agiNg (Mass-ENVISION) is a proposed new Alzheimer's-related Resource Centers for Minority Aging Research (AD/ADRD RCMAR) that will address the critical need for mentored research training for underrepresented in medicine (UiM) scientists in the development, testing, and implementation of ADRD behavioral interventions for minority older adults, their care partners and dyads. A collaboration of Massachusetts General Hospital, Boston University (BU), and Cambridge Health Alliance and their medical school and hospital affiliates, other Boston and MA-area research centers, and community clinics, Mass-ENVISION will provide RCMAR Scientists with sustained and tailored mentoring in ADRD behavioral health and interventions research using the revised NIH Stage Model, NIA Health Disparities Research Framework, and the Centers for Disease Control and National Academy of Medicine prevention models. Mass-ENVISION will have 4 Cores (Leadership and Administrative, Research Education Component, Data and Analysis, Community Liaison and Recruitment), and will collaborate closely with other NIA-funded Centers and their investigators, including the Massachusetts Alzheimer’s Disease Research Center (MADRC) and Boston University ADRC, to translate biological and epidemiological advances as mechanistic targets for ADRD behavioral interventions, to develop an inclusive research mentoring environment, and to train a diverse biomedical research workforce to advance health equity in ADRD behavioral health.

PI_NAMEs: OKEREKE, OLIVIA IFEOMA (contact)

PROGRAM_OFFICER_NAME: RICE, ELISE

PROJECT_TERMS: Academic Medical Centers;Academy;Address;Affect;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;American;Area;Asian;behavior change;Behavior Therapy;Behavioral;behavioral health;behavioral health intervention;Behavioral Research;Big Data Methods;Biological;Biological Markers;Biomedical Research;Black race;Boston;Capsicum;Caring;Cause of Death;Centers for Disease Control and Prevention (U.S.);clinical development;clinical implementation;clinical translation;Clinical Trials;Collaborations;college;Color;Communities;community clinic;community engaged research;community engagement;community organizations;community partners;community setting;Data;data complexity;Data Set;Data Sources;Dementia;Development;digital divide;digital health;disability;Discipline;disorder control;Education;education research;effective intervention;Ensure;Environment;Epidemiology;Equity;ethnic minority;evidence base;Face;Faculty;Funding;General Hospitals;Generations;Geriatric Psychiatry;Health;Health Alliance;Health Disparities Research;health disparity;health equity;Health equity research;health inequalities;health training;high risk;Hospitals;human old age (65+);implementation science;Inequity;informal care;Infrastructure;innovation;Institution;International;Intervention Studies;Justice;Latino;Leadership;Marketing;Massachusetts;Measurement;Measures;medical schools;Medicine;member;Mentors;Methodology;Methods;mHealth;Minority;minority engagement;Minority Health Research;Modeling;Neighborhoods;New England;novel;older adult;Older Population;Ontology;Participant;Persons;Positioning Attribute;Prevention;Prevention approach;Preventive;programs;Psychiatry;Qualitative Methods;Racial Equity;racial minority;Records;recruit;Research;Research Personnel;Research Training;Resources;Satellite Hospitals;Science;Scientist;segregation;Site;skills;skills training;social;social determinants;statistics;Structural Racism;success;System;Testing;Training;Training Support;Translating;United States National Institutes of Health;Universities;Voice;workforce needs


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research

PROJECT_TERMS: Academy;Achievement;Advocate;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;anti-racism;behavior change;Behavior Therapy;behavioral health;behavioral health intervention;Behavioral Research;Benchmarking;Biomedical Research;Boston;career;career development;Caring;Centers for Disease Control and Prevention (U.S.);Collaborations;Communities;community collaboration;community engaged research;community engagement;Community Participation;community partners;community setting;community-centered;Data;Dementia;Development;digital divide;education research;empowerment;Ensure;equity, diversity, and inclusion;Evaluation;experience;functional improvement;Funding;General Hospitals;Goals;health disparity;Hospitals;informal care;Infrastructure;Institution;Intervention;Intervention Studies;Investigation;Knowledge;Lead;Leadership;Massachusetts;Medicine;member;Mentors;Methodology;Minority;Minority Health Research;Mission;Modeling;Monitor;New England;next generation;novel;older adult;Patients;Performance;Persons;Pilot Projects;Prevention;Process;programs;recruit;Reporting;Research;Research Personnel;Research Project Grants;Resources;Risk Behaviors;Science;Scientist;skills;success;Supervision;System;Testing;Training;Training and Infrastructure;Training Support;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Leadership and Administrative Core (LAC)


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Telehealth

ORG_CITY: STORRS-MANSFIELD

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF CONNECTICUT STORRS

PHR: Traditional lifestyle interventions involve numerous visits for months which is not practical for many people. The proposed randomized trial will compare two telehealth lifestyle interventions, one that is delivered via videoconference meetings and one that is delivered asynchronously in a private Facebook group. Findings will provide evidence for two forms of telehealth-delivered lifestyle interventions.

PI_NAMEs: PAGOTO, SHERRY L. (contact)

PROGRAM_OFFICER_NAME: HALES, CRAIG MAURICE

PROJECT_TERMS: Address;arm;behavioral health;Body Weight decreased;comparison intervention;Computer software;cost;effective intervention;efficacious intervention;experience;Facebook;Human;interest;Intervention;Lead;lifestyle intervention;Maintenance;meetings;mobile application;Modeling;Outcome;Participant;patient engagement;Patients;peer;Persons;Phase;Policies;Privatization;Randomized;randomized trial;Randomized, Controlled Trials;remote delivery;remote group;remote health care;remote intervention;Research;scale up;Schedule;secondary outcome;synchronous delivery;systematic review;Teleconferences;telehealth;Telephone;Testing;Text;Time;trial comparing;videoconference;Videoconferencing;Visit;Weight;Work

PROJECT_TITLE: A non-inferiority trial comparing synchronous and asynchronous remotely-delivered lifestyle interventions

STUDY_SECTION: LCBH

STUDY_SECTION_NAME: Lifestyle Change and Behavioral Health Study Section[LCBH]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Data Science;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: HOEPPNER, BETTINA B. (contact)

PROJECT_TERMS: Aging;Alzheimer's Disease;Alzheimer's disease related dementia;American;Area;Behavior Therapy;behavioral and social science;behavioral health;behavioral health intervention;Behavioral Research;Boston;Capsicum;career;Collaborations;Common Data Element;Communities;Consultations;cooking;Data;Data Analyses;Data Collection;data harmonization;Data Sources;data standards;data structure;Dedications;Dementia;design;Development;digital health;Engineering;Ensure;Evaluation;experience;Feedback;Funding;General Hospitals;Goals;Health Alliance;health disparity;Hospitals;Individual;innovation;Investments;K-Series Research Career Programs;Knowledge;marginalization;Massachusetts;Measurement;Measures;medical schools;Medicine;member;Mentored Clinical Scientist Development Program;Mentors;Mentorship;Metadata;Methods;mHealth;mhealth interventions;Minority;Minority Groups;Minority Health Research;multiple data types;National Institute of Drug Abuse;Neuropsychology;novel;Patient Self-Report;PhenX Toolkit;Population;Process;programs;Psychometrics;Publications;R24;recovery community organization;recruit;Research;Research Activity;Research Design;Research Project Grants;Resources;Running;Science;Scientist;social science research;Stigmatization;Structural Racism;Structure;success;System;Technology;therapy development;tool;Training Programs;Translating;Translations;undergraduate student;United States National Institutes of Health;Universities;user centered design;Vision;Woman;Work

PROJECT_TITLE: Analysis Core (Anc)