NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Gene Therapy;Gene Therapy Clinical Trials;Genetic Testing;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Precision Medicine;Prevention;Rare Diseases

PI_NAMEs: MALETIC-SAVATIC, MIRJANA  (contact)

PROJECT_TERMS: Acceleration;Address;Algorithms;Alleles;Antisense Oligonucleotide Therapy;Antisense Oligonucleotides;Attention;Auditory Evoked Potentials;Bioinformatics;Biological;Biological Markers;biomarker identification;biomarker panel;biomarker signature;Biosensor;Blinking;Blood;Brain;candidate identification;Cell Line;Cells;clinic ready;Clinical;clinical phenotype;clinical trial readiness;Clinical Trials;Cognition;cognitive function;cohort;college;Communities;Complement;Complementary DNA;Complex;Copy Number Polymorphism;Data;Data Analyses;Data Set;design;Development;Developmental Gene;Disease;diverse data;DNA;dosage;Dose;Enrollment;Evoked Potentials;Fibroblasts;Foundations;Future;gain of function;Gene Dosage;Gene Expression;Gene Mutation;gene replacement;gene replacement therapy;Genes;Genetic;Genetic Markers;Goals;Human;Impairment;improved;Individual;individual patient;Induced Neurons;induced pluripotent stem cell;innovation;insight;Intellectual and Developmental Disabilities Research Centers;Intellectual functioning disability;interest;Learning;loss of function;Machine Learning;Mass Spectrum Analysis;Measurement;Measures;Mediator;Medicine;Memory;Mendelian disorder;metabolome;metabolomics;Methodology;Methyl-CpG-Binding Protein 2;Molecular;molecular marker;Molecular Profiling;mouse model;multimodal data;Mus;Mutation;Natural History;neural circuit;Neurologic;new technology;next generation;novel;Outcome Measure;overexpression;overtreatment;Participant;Pathology;Patients;Perception;Peripheral;Phenotype;Physiological;Population Study;Potocki-Lupski syndrome;precision medicine;prepulse inhibition;Proteins;Pupil;Recording of previous events;Research;Research Project Grants;response;RNA Splicing;Safety;Sensory;Services;Severities;Single Nucleotide Polymorphism;social skills;Somatosensory Evoked Potentials;Spinal Muscular Atrophy;Stimulus;Symptoms;Syndrome;Testing;Time;Titrations;tool;transcriptome;transcriptome sequencing;transcriptomics;Treatment Efficacy;Treatment-related toxicity;Visual evoked cortical potential;Work

PROJECT_TITLE: Clinical trial readiness biomarkers for gene dosage-dependent disorders


ADMINISTERING_IC: HD

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Disorders;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Mental Health;Networking and Information Technology R&D (NITRD);Pediatric

ORG_CITY: HOUSTON

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PI_NAMEs: LJUNGBERG, CECILIA  (contact)

PROJECT_TERMS: Animal Model;Area;Basic Science;Biochemical;Biological;Biological Markers;biomarker discovery;biomarker identification;Brain;brain tissue;Cell model;Cells;Cellular Metabolic Process;Clinical;Clinical Research;college;Complementary RNA;Complex;Computational Science;Computer software;Computing Methodologies;Data;Data Analyses;data integration;Data Science;design;Disease;disease model;Ensure;experimental analysis;Experimental Designs;experimental study;Faculty;Functional disorder;Funding;Future;Gene Expression;Gene Expression Profile;gene regulatory network;Genes;Genetic;Genetic Models;genetic regulatory protein;Genetic Transcription;gigabyte;Goals;Human;Image;improved;In Situ Hybridization;insight;instrument;instrumentation;Intellectual and Developmental Disabilities Research Centers;Intellectual functioning disability;Laboratories;Leadership;Liquid substance;Measurement;Measures;Medicine;Metabolism;metabolome;metabolomics;Methods;Modality;model organism;Modeling;Molecular;multiple omics;Nature;Neuronal Dysfunction;novel;Organism;Outcome;Pathogenicity;Patients;Performance;Phenotype;Post-Translational Protein Processing;protein complex;protein expression;Proteins;Proteome;Proteomics;recruit;Reporting;Research;Research Personnel;Resources;RNA;RNA analysis;Sampling;Scientist;Services;small molecule;Source;synergism;System;Technology;Testing;Tissue-Specific Gene Expression;Tissues;tool;transcriptome;transcriptome sequencing;transcriptomic profiling;transcriptomics;Translational Research;treatment strategy;Variant;Visualization;Work

PROJECT_TITLE: Molecular Expression Analysis


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: NEW YORK

ORG_DEPT: DERMATOLOGY

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: PROJECT NARRATIVE  Cutaneous squamous cell carcinoma (cSCC) is the second most common cancer overall in the United States, of which a substantial number of cases are unresectable and lack treatment options. Therapeutic strategies are limited in part due to poor understanding of how intratumoral heterogeneity (ITH) arises and triggers invasive behavior in cSCC, but recent work suggests that factors from the tumor microenvironment (TME) and cancer cell-intrinsic factors both contribute to ITH. This work aims to identify specific crosstalk pathways between the tumor and TME that lead to invasion and tumor progression to aid in developing therapeutic strategies to disable these processes.

PI_NAMEs: JI, ANDREW  (contact)

PROGRAM_OFFICER_NAME: BIAN, YANSONG

PROJECT_TERMS: Ablation;Affect;Antibodies;Behavior;Binding;Biochemical;cancer cell;Cancer cell line;cancer genetics;cancer type;Carcinoma;Cell Communication;Cell Line;cell type;Cells;Cessation of life;cohort;Communication;connective tissue growth factor;CRISPR screen;Data;Dermal;Development;Disabling;Exhibits;Fibroblasts;Fibronectins;Genes;Genetic;genetic manipulation;genetic signature;Heterogeneity;Histologic;Human;Immune;in vivo;Institution;Integrins;Intrinsic factor;Invaded;keratinocyte;Knock-out;Knowledge;Ligands;Link;Malignant - descriptor;Malignant Neoplasms;Mediating;Mentorship;Minority;Modeling;Molecular;Morbidity - disease rate;mouse model;Multiplexed Ion Beam Imaging;mutant;Neoplasms;neoplastic cell;Neoplastic Keratinocyte;novel;novel therapeutic intervention;Oncogenic;Organoids;Pathway interactions;Patients;Physicians;Pre-Clinical Model;prevent;Process;Prognosis;receptor;Recurrence;Research;Risk;Role;Scientist;Signal Transduction;single-cell RNA sequencing;Site;Skin;Skin Cancer;skin squamous cell carcinoma;Stromal Cells;Stromal Invasion;Therapeutic;transcriptomics;treatment strategy;tumor;Tumor Cell Invasion;tumor growth;tumor heterogeneity;tumor microenvironment;tumor progression;Tumor Promotion;tumorigenesis;tumorigenic;United States;Universities;Unresectable;Up-Regulation;Work;Xenograft procedure

PROJECT_TITLE: Cancer Cell-Extrinsic and Intrinsic Regulators of Tumorigenesis

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Pediatric

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE – Children's Hospital of Michigan The proposal is relevant to public health because Children's Hospital of Michigan (CHM) as a clinical site will bring a racially, ethnically, and socioeconomically diverse population of critically ill children as research participants to the CPCCRN. This diverse population will allow personalized treatment of sepsis-induced MODS to be fully investigated. CHM as a clinical site is relevant to the NICHD's mission that all children have the chance to fulfill their potential to live healthy and productive lives free from disease or disability.

PI_NAMEs: MEERT, KATHLEEN L. (contact)

PROJECT_TERMS: Address;Admission activity;American;American College of Surgeons;anakinra;antagonist;Anti-Inflammatory Agents;Area;Award;Beds;Blocking Antibodies;Burn Centers;Cardiac;cardiac intensive care unit;Cardiovascular system;Caring;Child;Childhood;Clinical;Clinical Research;clinical research site;Clinical Trials;Clinical Trials Data Monitoring Committees;Collaborations;Collection;Contracts;Critical Care;Critical Illness;Critically ill children;Data;Data Coordinating Center;Development;Dimensions;disability;Disease;Doctor of Philosophy;Dose;Enrollment;Ethnic Origin;expectation;experience;Faculty;Family;Functional disorder;functional status;Funding;Genetic;Goals;Good Clinical Practice;Granulocyte-Macrophage Colony-Stimulating Factor;Health;health related quality of life;high risk;Hospitals;immune function;Immunophenotyping;immunoregulation;immunosuppressed;Individual;Infant;Information Systems;innovation;Institution;Institutional Review Boards;Intensive Care;Interleukin 6 Receptor;Interleukin-1 Receptors;Lead;Leadership;Life;Medical;Medical center;Medicine;meetings;Mentored Clinical Scientist Development Program;Mentors;Methods;Michigan;mid-career faculty;Mission;Morbidity - disease rate;mortality;Multiple Organ Failure;National Institute of Child Health and Human Development;operation;Operative Surgical Procedures;Organ;Outcome;Participant;patient population;Pediatric Hospitals;pediatric trauma;Performance;personalized medicine;Physician Executives;Population Heterogeneity;Procedures;Productivity;professor;Program Development;programs;Protocols documentation;Public Health;Publications;Race;racial diversity;Randomized, Controlled Trials;Recombinants;Research;Research Personnel;Research Training;Resources;sample collection;Science;Scientist;Sepsis;Services;Severities;Site;socioeconomics;square foot;success;Survivors;Talents;tertiary care;tocilizumab;Translational Research;Trauma;trauma centers;Universities;Utah;Work

PROJECT_TITLE: Collaborative Pediatric Critical Care Research Network - Clinical Site


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Neurosciences;Pediatric;Prevention

ORG_CITY: SAINT LOUIS

ORG_DEPT: PSYCHIATRY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Emotion dysregulation contributes to many psychiatric disorders and results in significant impairment across multiple domains of function from social to health-related outcomes. This project will investigate the separable developmental trajectories, ability to predict impairment and psychopathology, and neural markers of clinical dysregulation of negative affect (irritability), clinical dysregulation of positive affect (excitability), and normative high positive affect (surgency). Elucidating the developmental effects of excitability and irritability will have implications for transdiagnostic models of psychiatric illness and will inform development of targeted interventions.

PI_NAMEs: VOGEL, ALECIA C. (contact)

PROGRAM_OFFICER_NAME: BECHTHOLT, ANITA JEAN

PROJECT_TERMS: 10 year old;Address;Affect;Affective;Age;Aggressive behavior;Amygdaloid structure;Anterior;Behavior;Behavioral;brain behavior;Child;Childhood;Clinical;clinical diagnosis;Data;Depressed mood;Development;developmental psychology;Diagnostic;Diagnostics Research;Dimensions;Disease;Disruptive Behavior Disorder;Down-Regulation;Early identification;Early Intervention;emotion dysregulation;emotion regulation;Emotional;emotional functioning;emotional stimulus;Emotions;Factor Analysis;Fright;Functional impairment;Functional Magnetic Resonance Imaging;functional MRI scan;Goals;Health;Impairment;improved;Individual;Individual Differences;Infant;Intervention;Interview;Left;Literature;longitudinal analysis;longitudinal design;Manic;Measurement;Measures;Mental disorders;Mentorship;Methodology;Methods;Modeling;Morbidity - disease rate;National Institute of Mental Health;negative affect;negative mood;neural;neural correlate;Outcome;Parents;Patient Self-Report;Personality;Phenotype;pleasure;Population;Positive Valence;Prefrontal Cortex;Process;Prognosis;psychiatric symptom;Psychopathology;Regulation;Research;resilience;response;Rewards;Risk;Risk Marker;Role;School-Age Population;social;Social Functioning;Stimulus;Strategic Planning;study population;symptomatology;Symptoms;System;Temperament;Time;Training;Ventral Striatum

PROJECT_TITLE: Understanding the role of dysregulation in positive affect in developmental psychopathology.

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PI_NAMEs: SILLITOE, ROY VINCENT (contact)

PROJECT_TERMS: 3-Dimensional;Acceleration;Address;Adult;Affect;Anatomy;Animals;Architecture;Ataxia;Behavior;Behavioral;behavioral outcome;Biological Models;Birth;Brain;brain abnormalities;brain tissue;cell assembly;Cell model;cell type;Cells;Cellular Structures;Child;Child Health;clinical phenotype;Cognitive;cognitive function;college;confocal imaging;Dedications;Defect;design;Development;developmental disease;Diagnosis;Disease;disease model;Disease Outcome;Drosophila genus;effective therapy;Electrons;Environmental Risk Factor;Epilepsy;Equipment;experience;experimental analysis;Faculty;forging;Generations;Genetic;Genetic study;genome editing;Goals;grasp;Histology;Human;human disease;human induced pluripotent stem cells;human model;human tissue;imaging capabilities;imaging modality;Imaging technology;improved;in utero;in vitro Assay;in vivo Model;Individual;Induced pluripotent stem cell derived neurons;Infrastructure;innovation;Intellectual and Developmental Disabilities Research Centers;Intellectual functioning disability;Knowledge;Link;Medicine;Microscope;Microscopy;Modeling;Modernization;Molecular;Motivation;Motor;mouse genetics;Mus;Nerve Degeneration;neural circuit;neural correlate;Neuroglia;Neurons;neuropathology;Organ;Organoids;Pathogenesis;Pathogenicity;Pathologic;Pathology;Patients;Personal Satisfaction;Phenotype;Population;Positioning Attribute;Postdoctoral Fellow;Rattus;Research Personnel;Research Project Grants;Resolution;Resources;response;Science;Services;Structure;student training;Synapses;synergism;Techniques;Tissues;tool;Training;Transmission Electron Microscopy;transmission process;two photon microscopy;two-photon;ultra high resolution;Visualization;Work

PROJECT_TITLE: Cellular and Tissue Pathogenesis


FUNDING_MECHANISM: NON-SBIR/STTR RPGS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Clinical Research;Mental Health;Neurosciences;Pediatric

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE Results from this study will help identify markers of vulnerability to psychopathology during early adolescence and early adulthood by investigating the neurodevelopmental mechanisms supporting the ability to modulate attention toward or away from emotional information in the context of goal-directed behavior, which is integral to emotion regulation. This information is lacking and critical for characterizing neurodevelopmental pathways of risk for internalizing and externalizing disorders. Additionally, the study will provide rigorous longitudinal data on the neurodevelopment of the ability to resist interference from emotional distracters contributing to the discovery of critical windows of brain plasticity when early interventions designed to strengthen neural networks supporting emotional interference resistance could be most effective in promoting emotion regulation.

PI_NAMEs: JONES, NEIL PATRICK (contact);LADOUCEUR, CECILE D.;VERSACE, AMELIA

PROGRAM_OFFICER_NAME: THOMAS, LAURA ANDERSON

PROJECT_TERMS: Acceleration;Address;Adolescence;Adult;Affective;Age;age related;Aging;Amygdaloid structure;Asian;attentional modulation;Behavior;biomarker identification;Black race;Brain;Childhood;critical developmental period;Data;design;Development;Diagnosis;Diagnostic;Diffusion Magnetic Resonance Imaging;Disease;early adolescence;Early Intervention;emerging adult;emotion dysregulation;emotion regulation;Emotional;emotional stimulus;Event-Related Potentials;Functional Magnetic Resonance Imaging;Goals;Graph;high risk;improved;indexing;Intervention;Knowledge;Latinx;Life;Life Stress;Link;longitudinal design;Measures;medial temporal lobe;Modality;Modeling;Motivation;multi-racial;multimodal neuroimaging;multimodality;Natural regeneration;neural;neural network;neurodevelopment;Participant;Pathology;Pathway interactions;Pattern;Performance;Play;Prefrontal Cortex;preservation;Psychopathology;Puberty;recruit;Research;Resistance;response;Risk;Role;Sampling;sex;Short-Term Memory;Stimulus;Stress;stressor;Structure;support network;sustained attention;Symptoms;Task Performances;Temporal Lobe;Testing;therapy design;transition to adulthood;Visit;Visual System;white matter;young adult

PROJECT_TITLE: Neurodevelopment of Emotional Interference Resistance in Adolescence to Adulthood: A Multimodal Neuroimaging Approach


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biotechnology;Brain Disorders;Disability Research;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric

PI_NAMEs: ARENKIEL, BENJAMIN R (contact)

PROJECT_TERMS: Acoustics;adeno-associated viral vector;Affect;Animal Model;Animals;Attention;Behavior;Behavioral;Biological Assay;Biological Markers;Brain;Brain Stem;Cell Communication;Cell Culture Techniques;cell type;Chronic;Clinical;Cognition;college;Communities;cost effective;cost efficient;Custom;Deep Brain Stimulation;Dependovirus;design;developmental disease;Disability treatment;Disease;disease model;Electrophysiology (science);emerging virus;Engineering;Experimental Designs;experimental study;flexibility;Functional disorder;Functional Imaging;gain of function;Gene Expression;Generations;Genetic;genetic approach;genetic manipulation;Goals;Human;Image;In Vitro;in vivo;Individual;Intellectual and Developmental Disabilities Research Centers;Intellectual functioning disability;Investigation;knock-down;Laboratories;Lentivirus;Light;Maps;Measurement;Medicine;member;Methods;Molecular;motor deficit;mouse model;Mus;Nerve Tissue;Nervous System Disorder;Nervous System Physiology;neural;neural circuit;Neurons;neurophysiology;neuroregulation;Neurosciences;neurotropic;neurotropic virus;novel;Optics;optogenetics;Outsourcing;Pathway interactions;Pattern;Physiologic pulse;Physiological;pre-clinical;preclinical study;Preparation;prepulse inhibition;Production;programs;Property;Proteins;Pupil;Readiness;Reagent;Reporter;Reproducibility;Research;Research Personnel;response;Rodent;Rodent Model;Sensory;sensory gating;Services;Slice;small hairpin RNA;sound;Startle Reaction;Synapses;System;Techniques;Technology;Testing;Time;Tissues;tool;Tracer;Transgenic Mice;Transgenic Organisms;Translating;two-photon;Viral;Viral Vector;Virus;Work

PROJECT_TITLE: Circuit Analysis and Modulation


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics;Microbiome

ORG_CITY: SAN FRANCISCO

ORG_NAME: NORTHERN CALIFORNIA INSTITUTE/RES/EDU

ORG_STATE: CA

PHR: NARRATIVE The microbes in the gut can contribute to disease and inflammation, but we lack fundamental knowledge about how microbial genes impact inflammation or treatment. We plan to use new state-of-the-art genomic technologies to understand how gut microbes respond and contribute to inflammation. This information will be critical to more effectively design new therapies that target the microbes in our gut.

PI_NAMEs: NAYAK, RENUKA RAJENDRA (contact)

PROGRAM_OFFICER_NAME: ZHAO, XIAOLI

PROJECT_TERMS: Biological Response Modifier Therapy;Clinical Immunology;computer science;design;Disease;Drug Targeting;Ecology;Evolution;fecal transplantation;Future;Genes;Genetic;Genetic Determinism;Genomics;Goals;Grant;gut microbes;gut microbiome;gut microbiota;Health;Human;improved;in vivo;Inflammation;Inflammatory;inhibitor;Knowledge;Microbe;microbial;microbial community;Microbial Genetics;Microbiology;microbiome;National Institute of General Medical Sciences;new therapeutic target;Pathway interactions;Patients;Pharmaceutical Preparations;Pharmacotherapy;Productivity;programs;rational design;Research;Resolution;response;Shapes;small molecule;systemic inflammatory response;targeted treatment;Technology;Treatment Efficacy

PROJECT_TITLE: From here to eternity: gut microbial response to drug therapy and inflammation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MGG-J(55)R]


NIH_SPENDING_CATS: Clinical Research;Health Services;Hematology;Infectious Diseases;Pediatric;Sepsis

PHR: PROJECT NARRATIVE – Children’s Hospital of Philadelphia This proposal is relevant to public health because Children’s Hospital of Philadelphia (CHOP) as a clinical site will bring a racially, ethnically, and socioeconomically diverse population of critically ill children as research participants to the CPCCRN. This diverse population will allow personalized treatment of sepsis- induced MODS to be fully investigated. CHOP as a clinical site will contribute to the NICHD’s mission that all children have the opportunity to fulfill their potential to live healthy and productive lives free from disease or disability.

PI_NAMEs: ZUPPA, ATHENA F. (contact)

PROJECT_TERMS: Address;Agreement;anakinra;antagonist;Anti-Inflammatory Agents;Award;Beds;Blocking Antibodies;Budgets;career development;Caring;Child;Childhood;Clinical and Translational Science Awards;clinical center;Clinical Research;clinical research site;Clinical Sciences;Clinical Trials;Clinical Trials Data Monitoring Committees;Collaborations;Collection;Companions;Contracts;Country;Critical Care;Critical Illness;Critically ill children;Data;Data Collection;Data Coordinating Center;Dedications;Development;disability;Discipline of Nursing;Disease;Dose;electronic data;Eligibility Determination;Ethnic Origin;expectation;experience;Faculty;Family;Feedback;Functional disorder;Funding;Good Clinical Practice;Granulocyte-Macrophage Colony-Stimulating Factor;health related quality of life;Home;Human;Immune;immune function;Immune Targeting;Immunophenotyping;immunoregulation;immunosuppressed;Immunosuppression;Individual;Infant;innovation;Institution;Institutional Review Boards;Interleukin 6 Receptor;Interleukin-1 Receptors;International;Intervention;Journals;Leadership;Medical;Medicine;meetings;Mentors;Mentorship;Methods;Mission;Morbidity - disease rate;mortality;Multi-Institutional Clinical Trial;Multiple Organ Failure;National Heart, Lung, and Blood Institute;National Institute of Child Health and Human Development;Network Infrastructure;news;next generation;Observational Study;Operative Surgical Procedures;Organ;Outcome;Participant;participant enrollment;patient population;Patients;pediatric department;Pediatric Hospitals;Pediatric Research;Performance;personalized medicine;Persons;phenomics;Phenotype;Philadelphia;Physician Executives;Population;Population Heterogeneity;Procedures;Productivity;professor;programs;Protocols documentation;Public Health;Publications;Race;racial diversity;Recombinants;Reporting;Research;Research Personnel;Research Training;Risk Factors;Role;sample collection;Sampling;Science;Scientist;Sepsis;septic;Site;socioeconomics;square foot;success;Syndrome;System;Talents;tertiary care;Time;tocilizumab;Training;Translational Research;United States National Institutes of Health


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric

PI_NAMEs: SAMACO, RODNEY C (contact)

PROJECT_TERMS: Address;Animal Behavior;animal data;Animal Model;Animals;Assessment tool;Back;Basic Science;Behavior assessment;behavior test;Behavioral;Behavioral Assay;bench to bedside;biobehavior;Biological Assay;Clinical;Clinical assessments;clinical investigation;Clinical Investigator;clinical outcome assessment;clinical outcome measures;clinical phenotype;clinical translation;Clinical Trials;Cognitive;college;Computer Vision Systems;Consultations;Core Facility;cost effective;Data Analyses;design;Development;Disease;disease model;Educational workshop;Ensure;Evaluation;Experimental Designs;experimental study;Facial Expression;Faculty;Fee-for-Service Plans;flexibility;Follow-Up Studies;Future;gaze;Goals;Human;human data;human model;human subject;Industry Standard;Infrastructure;innovation;Intellectual and Developmental Disabilities Research Centers;Intervention;Interview;investigator training;life span;Measures;Medicine;Mental Health;Methods;Modality;Modeling;multimodality;Nature;neurobehavioral;Neurologic;neuropsychiatry;Neuropsychology;novel;novel strategies;novel therapeutic intervention;novel therapeutics;Outcome;Outcome Assessment;Outcome Measure;Patients;Phenotype;Physiological;Posture;pre-clinical;Preclinical Testing;Protocols documentation;quality assurance;Questionnaires;Reproducibility;Research;Research Personnel;Resources;Rodent;Rodent Model;Science;Service delivery model;Services;social;Structure;Supervision;Surrogate Endpoint;Techniques;Testing;tool;Training;Translating;translational pipeline;Translational Research;Translations;Work

PROJECT_TITLE: Preclinical and Clincial Outcomes


ADMINISTERING_IC: EY

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Data Science;Diabetes;Eye Disease and Disorders of Vision;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Patient Safety;Prevention;Primary Health Care

ORG_CITY: STILLWATER

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: OKLAHOMA STATE UNIVERSITY STILLWATER

ORG_STATE: OK

PHR: Although diabetic retinopathy (DR) is the leading cause of blindness among American adults, many diabetic patients do not comply with the recommended ophthalmic exams because DR is asymptomatic in the early stages, and thus patients miss the most effective period to halt DR progression and prevent vision loss. To improve the compliance rate of the recommended ophthalmic exams and detect DR early, our long-term goal is to develop a cost-effective, nonimage based, artificial intelligence (AI) tool for primary care physicians to assess patients’ risk for DR using routine lab results, and recommend ophthalmic exams and personalized screening frequency for at-risk patients confidently. As the next step in pursuing this goal, this project aims to develop advanced machine learning algorithms to realize the full potential of electronic-healthrecord (EHR) data by harnessing tensor information to improve the quality of EHR data and prediction accuracy.

PI_NAMEs: LIU, TIEMING  (contact)

PROGRAM_OFFICER_NAME: GAO, JAMES

PROJECT_TERMS: access restrictions;Accounting;Address;Adult;adversarial learning;American;Architecture;Artificial Intelligence;Bayesian Modeling;Blindness;Caring;Classification;Clinical;comorbidity;Complex;convolutional neural network;cost effective;Data;data imputation;data quality;Data Set;data structure;Databases;Decision Making;deep learning;deep neural network;design;Detection;diabetic;diabetic patient;Diabetic Retinopathy;Diagnosis;Dimensions;Disease;Disease Progression;Early Diagnosis;Electronic Health Record;electronic structure;Electronics;Equipment;Eye;Frequencies;fundus imaging;Future;generative adversarial network;Goals;Health;Health Care Costs;Health Insurance Portability and Accountability Act;Healthcare;High Prevalence;improved;Income;Individual;innovation;Learning;longitudinal analysis;loss of function;Machine Learning;machine learning algorithm;Measures;Medical;medical attention;Medical History;Methodology;Methods;Minority;Modeling;multidimensional data;network architecture;Network-based;Neurons;novel;Patient risk;Patients;Pattern;personalized screening;Persons;Physicians;predictive modeling;prevent;Prevention;Primary Care Physician;Process;Recommendation;relational database;Risk;Rural Community;screening;secondary analysis;statistics;Techniques;Time;tool;Training;training data;Treatment outcome;Uncertainty;urban area;Visually Impaired Persons

PROJECT_TITLE: SCH: Harnessing Tensor Information to Improve EHR Data Quality for Accurate Data-driven Screening of Diabetic Retinopathy with Routine Lab Results

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-VH-N(50)R]


PHR: PROJECT NARRATIVE - Duke University By joining the newly organized and expanded Collaborative Pediatric Critical Care Research Network, Duke Children’s and our ancillary site at the Medical University of South Carolina will enhance the scientific breadth and reach of the network. Our sites are the leading academic centers in North and South Carolina, and will ensure that critically ill children in both states have access to the cutting edge clinical trials and research studies conducted by the network. Building on our experiences and expertise, we will provide deep scientific expertise and training and mentoring opportunities to enrich the network with a focus on the areas of clinical pharmacology, real-world evidence generation, and regulatory science.

PI_NAMEs: HORNIK, CHRISTOPH  (contact)

PROJECT_TERMS: Admission activity;Analgesics;Area;Beds;Biometry;Board Certification;Cardiology;career;career development;Child;Childhood;Clinical;Clinical Pharmacology;Clinical Research;clinical research site;Clinical Trials;Clinical Trials Network;Collaborations;Comprehensive Health Care;Contracts;Critical Care;Critical Illness;Critically ill children;Data;Data Coordinating Center;Dedications;Development;Development Plans;Doctor of Philosophy;Drug Labeling;early-career faculty;Electronic Health Record;Enrollment;Ensure;expectation;experience;Extramural Activities;Faculty;Funding;Generations;Goals;Good Clinical Practice;Government;immunoregulation;improved outcome;Individual;Infant;innovation;Intensive Care;Intervention;Joints;Leadership;Life;Medical;medical schools;Medicine;meetings;member;Mentors;Mentorship;Morbidity - disease rate;mortality;Multi-Institutional Clinical Trial;National Center for Advancing Translational Sciences;National Institute of Child Health and Human Development;Network Infrastructure;North Carolina;Nutritional Study;Participant;participant enrollment;Pediatric Acute Lung Injury;pediatric department;Pediatric Hospitals;Performance;Pharmaceutical Preparations;Pharmacoepidemiology;Pharmacologic Substance;pharmacometrics;Principal Investigator;Procedures;programs;Protocols documentation;Public Health;Publications;Recording of previous events;Research;Research Infrastructure;Research Institute;Research Personnel;research study;Research Training;Resources;Science;Scientist;sedative;Sepsis;Services;Site;South Carolina;success;Talents;Training;United States Food and Drug Administration;United States National Institutes of Health;Universities;Work


ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: For over 40 years, the UCLA IDDRC has committed to improving the lives of individuals with intellectual and developmental disabilities (IDDs) through basic and translational research, education, and outreach. Our center aims to provide outstanding resources and infrastructure to UCLA researchers focused on IDDs using the most innovative technologies that will significantly impact the well-being of individuals with IDDs and their families. This application requests 5 years of funding to support our Core infrastructure and a novel multidisciplinary project that examines the origins of abnormal sleep physiology and cognition. A new dissemination program extends our reach into the community to enhance inclusiveness and two-way communication with the public and stakeholders.

PI_NAMEs: BOOKHEIMER, SUSAN Y (contact);KORNBLUM, HARLEY IAN

PROGRAM_OFFICER_NAME: PARISI, MELISSA

PROJECT_TERMS: 3-Dimensional;Accountability;Advocacy;Animal Behavior;Animal Model;Animals;Basic Science;behavioral phenotyping;Bioinformatics;Biological Models;Biometry;Brain;Cells;chromosome 15q duplication syndrome;Clinical;clinical translation;Clinical Trials;Clinical Trials Design;Cognition;Collaborations;Collection;Communication;Communities;Community Outreach;community partners;community partnership;community-centered;Consultations;Core Facility;data management;data sharing;Databases;design;Development;developmental neurobiology;Diagnosis;Discipline;Education;Education and Outreach;Educational workshop;effective therapy;Electrophysiology (science);Environment;Epigenetic Process;Equipment and supply inventories;experimental study;Faculty;Family;financial incentive;Fostering;Functional Imaging;Functional Magnetic Resonance Imaging;Funding;Gene Expression;Genetic;genetic analysis;genomic data;Genomics;Genotype;Goals;Grant;Group Meetings;Health Fairs;Human;human induced pluripotent stem cells;Image;Impaired cognition;improved;In Vitro;in vivo;Individual;induced pluripotent stem cell;Infrastructure;innovation;innovative technologies;Intellectual and Developmental Disabilities Research Centers;Intellectual functioning disability;interdisciplinary approach;interdisciplinary collaboration;Interdisciplinary Study;Intervention;Lead;lectures;life span;meetings;Methods;Microscopy;Minority;Mission;model development;Modeling;multidisciplinary;neurodevelopment;new technology;novel;optogenetics;Organoids;outreach;Parents;patient derived induced pluripotent stem cells;Patients;Personal Satisfaction;Phenotype;program dissemination;recruit;Request for Applications;Request for Proposals;Research;Research Personnel;Research Project Grants;Research Proposals;Research Support;Resources;Rett Syndrome;Schools;Science;Scientist;Series;Services;Sleep;sleep abnormalities;Sleep disturbances;sleep physiology;Slow-Wave Sleep;Special Event;Spectrum Analysis;structural imaging;Structure;symposium;System;Systems Analysis;Technology;tool;Training;Translating;Translational Research;Universities;Visit;Visualization;voucher;Washington;working group

PROJECT_TITLE: UCLA IDDRC


NIH_SPENDING_CATS: Brain Disorders;Cost Effectiveness Research;Disability Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric

PI_NAMEs: BOOKHEIMER, SUSAN Y (contact)

PROJECT_TERMS: Abbreviations;Administrator;Advisory Committees;Advocacy;Advocate;Animals;Bioinformatics;central database;Clinical;clinical translation;Collaborations;Communication;Communities;community center;community partners;Cost efficiency;cost efficient;cost-effectiveness evaluation;Development;Developmental Disabilities;digital;Disability research;Discipline;Education;Educational workshop;Ensure;Environment;Evaluation;Faculty;Feedback;Funding;Goals;Human;Infrastructure;innovation;Institution;Intellectual and Developmental Disabilities Research Centers;Intellectual functioning disability;Investigation;Lead;Leadership;Learning;lectures;meetings;Minority;minority communities;Mission;Monitor;multidisciplinary;Occupational activity of managing finances;outreach;Parents;Patient Recruitments;programs;quality assurance;Reporting;Research;Research Personnel;Resources;Scientific Advances and Accomplishments;scientific hub;Scientist;Secure;Services;Students;symposium;synergism;System;Training;Training and Education;training opportunity;Translational Research;translational scientist;United States National Institutes of Health;Universities;Washington;web site;Work

PROJECT_TITLE: UCLA IDDRC: Administrative Core


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Prostate Cancer;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human;Urologic Diseases

ORG_DEPT: SURGERY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE Although prostate cancer stem cells have been investigated for the past twenty years, it has been difficult to provide definitive evidence for their existence or properties. In part, previous studies have been hampered by the lack of high-resolution methods to examine the behavior of individual cells within tumors, such as single-cell RNA-sequencing, as well as sophisticated computational approaches for the precise identification of candidate markers. Leveraging techniques from theoretical physics and algebraic topology, we will provide a statistical framework to identify and characterize tumor stem cells using single-cell data, and will validate our findings using mouse models and human prostate tumor samples.

PI_NAMEs: RABADAN, RAUL  (contact);SHEN, MICHAEL M.

PROGRAM_OFFICER_NAME: MILLER, DAVID J

PROJECT_TERMS: 3-Dimensional;Address;Affect;algebraic topology;androgen independent prostate cancer;Androgens;Automobile Driving;Behavior;Biological Assay;Biology;Cancer Biology;cancer stem cell;candidate identification;candidate marker;Castration;Cell Fraction;Cell Separation;cell type;Cells;Complex;Data;Data Analyses;Data Set;denoising;deprivation;Development;drug candidate;Drug Targeting;epigenomics;Epithelial Cells;epithelial stem cell;Evolution;experimental study;Genes;Genetically Engineered Mouse;Heterogeneity;Human;Individual;innovation;insight;Investigation;Knock-out;Laboratories;Location;Malignant neoplasm of prostate;Malignant Neoplasms;Masks;mathematical methods;Methods;Modeling;Molecular;Molecular Profiling;mouse model;Mus;Nature;neuroendocrine differentiation;new therapeutic target;novel;novel therapeutics;Organoids;overexpression;Patients;Physics;Process;progenitor;Property;Prostate;prostate cancer cell;prostate cancer model;prostate cancer progression;Prostatic Intraepithelial Neoplasias;Prostatic Neoplasms;Psychological Techniques;Recurrent disease;Regulator Genes;representation theory;Research Personnel;Resistance;Resolution;response;Role;Sampling;self-renewal;single cell technology;single-cell RNA sequencing;spatial integration;Specimen;Statistical Models;Stem Cell Assay;stem cell biology;stem cell model;stem cells;stem-like cell;Structure;success;Target Populations;targeted treatment;Techniques;Testing;theories;therapeutic target;therapeutically effective;Time;Tissue Microarray;Tissues;tool;transcriptomics;tumor;tumor initiation;tumor progression;Tumor Stem Cells;tumorigenic;Validation;Work

PROJECT_TITLE: A transdisciplinary approach for dissecting stem cell states in prostate cancer


NIH_SPENDING_CATS: Brain Disorders;Disability Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric;Prevention

PI_NAMEs: MCCRACKEN, JAMES T. (contact)

PROJECT_TERMS: Address;Basic Science;Behavioral;Biological Specimen Banks;Biology;career;Child;Clinical;clinical investigation;Clinical Investigator;clinical phenotype;Clinical Research;clinical research site;clinical translation;Clinical Trials;Cognitive;Competence;Consultations;cost;Cost efficiency;data management;Development;Diagnosis;Diagnostic;Disability research;Evaluation;Fostering;Individual;innovation;instrument;Intellectual and Developmental Disabilities Research Centers;Intellectual functioning disability;interest;Intervention Trial;Knowledge;life span;Longitudinal Studies;Machine Learning;Maintenance;Measurement;Measures;Methodology;Methods;minimally verbal;Mission;Motor;multidisciplinary;Neurologic;novel;outreach;Patients;Phenotype;Prevention;Procedures;Quality Control;recruit;Registries;Research;Research Design;Research Personnel;response;Risk;Scientific Advances and Accomplishments;Site;Sleep;social;theories;Time;tool;Training;translational goal;Translational Research

PROJECT_TITLE: UCLA IDDRC: Translational Core


NIH_SPENDING_CATS: Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Pediatric;Rural Health;Social Determinants of Health

PHR: PROJECT NARRATIVE – University of Colorado Denver This proposal for the University of Colorado Denver/Children’s Hospital Colorado Pediatric Critical Care Program and our ancillary site, Arkansas Children’s Hospital, to participate in the CPCCRN describes our institutions’ commitment to pediatric critical care research and training junior investigators as well as the extensive capabilities, experience, investigations, and patient population which we will contribute to the network. Our institutions represent large geographically unique and diverse populations of children, which will ensure CPCCRN studies embody the diversity of our nation and the findings are generalizable to all critically ill and injured children.

PI_NAMEs: MOURANI, PETER M (contact)

PROJECT_TERMS: Acute;Acute Lung Injury;Acute Renal Failure with Renal Papillary Necrosis;Address;Admission activity;alveolar epithelium;Area;Arkansas;Award;Basic Science;Blood Vessels;carbohydrate metabolism;Cardiopulmonary;Cardiovascular Diseases;career development;Caring;Catchment Area;Child;Child Development;Child Health;Childhood;Childhood Injury;Clinical;Clinical and Translational Science Awards;Clinical Research;clinical research site;Clinical Sciences;clinical translation;Clinical Trials;cohort;Collaborations;Colorado;Complement Activation;Contracts;Critical Care;Critical Illness;Critically ill children;Data;Data Coordinating Center;Development;Discipline;Disease;effective therapy;Ensure;Ethnic Origin;Evaluation;expectation;experience;Faculty;Family;follow-up;Functional disorder;Funding;Geography;Goals;Good Clinical Practice;Hospitalization;Immune response;immunoregulation;improved outcome;innovation;Institution;Investigation;Knowledge;Laboratories;Leadership;Link;Location;Longitudinal Studies;Lower Respiratory Tract Infection;Lung;Lung Diseases;medically underserved;Medicine;meetings;member;Mentored Clinical Scientist Development Program;Mentors;Metadata;Mission;Mississippi;Molecular;multidisciplinary;Multiple Organ Failure;National Heart, Lung, and Blood Institute;next generation;Organ;Outcome;Outpatients;outreach program;Participant;participant enrollment;pathogen;Pathogenesis;patient population;Patients;Pediatric Acute Lung Injury;Pediatric Acute Respiratory Distress Syndrome;pediatric department;Pediatric Hospitals;Performance;personalized therapeutic;Physicians;Population;Population Heterogeneity;Principal Investigator;Procedures;Process;Program Development;programs;Protocols documentation;Publications;pulmonary vascular disorder;Race;Recording of previous events;Rehabilitation therapy;Research;Research Design;Research Institute;Research Personnel;Research Priority;Research Training;Resources;Respiratory Failure;respiratory microbiome;Role;Rural;Scientific Advances and Accomplishments;Scientist;Sepsis;Series;severe injury;Site;socioeconomics;success;Talents;Technology;Training;Training Programs;Translational Research;Translational trial;Translations;Traumatic Brain Injury;underserved community;United States National Institutes of Health;Universities;Work


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Rare Diseases;Rett Syndrome;Sleep Research;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Women's Health Research

PI_NAMEs: NOVITCH, BENNETT G (contact)

PROJECT_TERMS: Address;Affect;Age;Animal Model;Attenuated;behavioral impairment;behavioral outcome;Biological Models;biomarker development;Brain;Calcium;Cells;Child;Clinical;clinical investigation;Clinical Trials;Cognition;Cognitive;cognitive development;cognitive function;Collaborations;comparison control;Data;Defect;density;Development;effective therapy;Electroencephalography;Electrophysiology (science);Event;Fostering;Funding;Future;Generations;Genetic;Genomics;Hippocampus;Human;Image;imaging modality;Impaired cognition;Impairment;improved;induced pluripotent stem cell;Informatics;Intellectual and Developmental Disabilities Research Centers;Intellectual functioning disability;interdisciplinary approach;interest;Intervention;Investigation;Learning;Measures;Memory;memory consolidation;Microscope;miniaturize;Modeling;Molecular;mouse model;network dysfunction;neural;neural network;Neurons;non rapid eye movement;non-verbal;novel;Organoids;Outcome;Pathway interactions;patient derived induced pluripotent stem cells;Patients;Play;pre-clinical;Pre-Clinical Model;Process;Quality of life;recruit;Research Personnel;Research Project Grants;Rett Syndrome;Role;Severities;skills;Sleep;sleep abnormalities;Sleep Architecture;sleep behavior;Sleep Disorders;Sleep disturbances;Sleep Fragmentations;sleep physiology;sleep spindle;Slow-Wave Sleep;Syndrome;System;Techniques;therapeutic target;transcriptome;transcriptomics;translational approach;verbal;Visualization

PROJECT_TITLE: Mechanisms underlying non-REM sleep and neural oscillation abnormalities in Dup15q and Rett Syndrome: Effects on Intellectual Disability


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric

ORG_CITY: JACKSON

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF MISSISSIPPI MED CTR

ORG_STATE: MS

PHR: PROJECT NARRATIVE The ECHO IDeA States Pediatric Clinical Trials Network-2 (ISPCTN-2) seeks to develop research that closes gaps that exist in maternal, infant, and child health, seeking to reduce rates of preterm birth and infant mortality by increasing access to pediatric clinical trials in rural and underserved communities. The Mississippi ECHO ISPCTN-2 (MS-CTN2) project provides a vital pediatric research resource in rural and medically underserved communities in the deep South. MS-CTN2 creates access for historically disenfranchised pediatric populations to participate in multisite pediatric trials and, in turn, these children and their families contribute to findings that inform the health of all children.

PI_NAMEs: MAJURE, JOSEPH MARC (contact)

PROGRAM_OFFICER_NAME: RAJU, TONSE N

PROJECT_TERMS: Achievement;Address;Advisory Committees;Airway Disease;Award;Biological Markers;Child;Child Health;Childhood;clinical center;Clinical Research;clinical trial readiness;Clinical Trials;Clinical Trials Network;Collaborations;Communities;community partners;Data;Deep South;Development;Disease;Drug Kinetics;Education;education research;Ensure;executive function;experience;Exposure to;Faculty;Family;Feedback;Funding;Future Generations;Grant;Health;Health Priorities;high risk infant;Hour;improved;in utero;Infant;Infant Care;Infant Health;Infant Mortality;inflammatory marker;Infrastructure;Institution;institutional capacity;Intervention;Leadership;Maternal Health;Medical center;medically underserved;Mississippi;Monitor;Multicenter Trials;multidisciplinary;neurodevelopment;novel;Obesity;obesity-associated asthma;operation;Opioid;Outcome;parenting intervention;Participant;pediatric department;Pediatric Research;Pharmaceutical Preparations;Population;postnatal;Premature Birth;Principal Investigator;programs;Protocols documentation;psychosocial;Readiness;recruit;Regulation;Research;Research Infrastructure;Research Personnel;Research Training;Resources;Rural;Rural Community;rural underserved;Security;senior faculty;Site;skills;standard of care;Stress;Structure;success;Teacher Professional Development;Testing;Training;Translational Research;trial readiness;underserved community;United States National Institutes of Health;Universities;Vitamin D supplementation;Work;working group

PROJECT_TITLE: Mississippi site (Mississippi ECHO ISPCTN-2 (MS-CTN2)


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Disorders;Data Science;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Mental Health;Networking and Information Technology R&D (NITRD);Neurosciences;Pediatric

PI_NAMEs: GANDAL, MICHAEL  (contact)

PROJECT_TERMS: analysis pipeline;analytical method;Animal Model;ATAC-seq;Atlases;Automobile Driving;Basic Science;Bioinformatics;Biological Assay;Brain;Cell model;Cell Nucleus;Cells;Chromatin;Clinical;cohort;Collaborations;Computerized Medical Record;computing resources;Data;data access;Data Analyses;data mining;Data Set;data sharing;Data Storage and Retrieval;Database Management Systems;Databases;Dedications;design;Development;Environment;Epigenetic Process;Equipment and supply inventories;exome sequencing;experience;experimental analysis;Experimental Designs;Experimental Models;experimental study;Explosion;fetal;Foundations;functional genomics;Funding;Gene Expression;Gene Expression Profiling;Genes;Genetic;genetic approach;Genetic study;Genome;genome-wide;Genomic approach;genomic data;Genomics;Genotype;Goals;High Performance Computing;Human;Informatics;Infrastructure;innovation;Institution;Intellectual and Developmental Disabilities Research Centers;Investigation;Journals;Knowledge;Laboratories;Lead;Maps;Medical Genetics;Methods;Methylation;Modernization;multiple datasets;Nature;Network-based;neurogenesis;neuroimaging;Neurons;Neurosciences;new technology;next generation sequencing;Online Systems;Paper;Pathway Analysis;Patients;Phenotype;polygenic risk score;Postdoctoral Fellow;Pregnancy;Privatization;Process;Protocols documentation;Publications;Publishing;Quantitative Trait Loci;Recording of previous events;Regulatory Element;Research;Research Design;Research Personnel;Resolution;Resource Informatics;Resources;RNA Splicing;Running;Science;Services;single cell analysis;single-cell RNA sequencing;Solid;student training;Students;Study models;Technology;tool;Training;transcriptome sequencing;translational genetics;translational study;United States National Institutes of Health;Untranslated RNA;Update;Validation;web-based tool;Work

PROJECT_TITLE: UCLA IDDRC: Functional Genomics and Genetics Core


NIH_SPENDING_CATS: Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

ORG_CITY: CHICAGO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Although genetic studies of complex traits have found many trait-associated loci, they rarely reveal new biology and they yield genetic predictions biased toward European-ancestry individuals. Studies of interactions between genes (GxG) or between genes and the environment (GxE) have potential to address these limitations, but current models are unrealistic and underpowered. I will develop new rigorous models of GxG and GxE and apply them in diverse ancestries and traits—from single cell ‘omics to Major Depressive Disorder—to better understand complex trait biology and to improve equity in genetic medicine.

PI_NAMEs: DAHL, ANDREW  (contact)

PROGRAM_OFFICER_NAME: MASKERI, BAISHALI

PROJECT_TERMS: Address;Area;biobank;Biological;Biology;cell type;Cells;Clinical;cohort;Complex;Complex Genetic Trait;Data;Disease;Environment;Environmental Risk Factor;Equity;European ancestry;gene environment interaction;gene interaction;Genes;Genetic;Genetic Epistasis;Genetic Medicine;genetic predictors;Genetic study;health disparity;Heritability;Human;improved;Individual;Link;Major Depressive Disorder;Mathematics;Methods;Modeling;novel;Pathway interactions;phenome;pleiotropism;portability;precision medicine;Scanning;trait;treatment response

PROJECT_TITLE: Novel statistical genetics methods to unravel polygenic interactions in complex traits

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human;Stem Cell Research - Nonembryonic - Human

PI_NAMEs: KORNBLUM, HARLEY IAN (contact)

PROJECT_TERMS: 3-Dimensional;Acute;Animal Model;Bioinformatics;Biology;Brain;Calcium;Cell Culture Techniques;cell dimension;Cell model;cell type;Cells;Central Nervous System;Cerebrum;clinical translation;Comprehensive Cancer Center;Development;Disease;disease model;DNA Sequence Alteration;drug development;drug discovery;Electroencephalography;Electrophysiology (science);Ethology;experimental study;Flow Cytometry;Functional Imaging;Gene Expression Profile;Genetic;Genomics;Human;human embryonic stem cell;human induced pluripotent stem cells;human pluripotent stem cell;Image;in vivo;induced pluripotent stem cell;Intellectual and Developmental Disabilities Research Centers;Intellectual functioning disability;Methodology;Modeling;Molecular;Morphology;Mus;Mutation;nerve stem cell;Nervous System Physiology;neural;Neurons;neurophysiology;novel;novel strategies;novel therapeutics;optogenetics;Organoids;Physiological;Pluripotent Stem Cells;progenitor;Proxy;Rattus;Research;Research Personnel;Research Project Grants;Resource Sharing;Rodent;Role;screening;Services;Slice;stem;Stem Cell Research;stem cell technology;stem cells;System;Techniques;Therapeutic;Tissues;tool;Training;Visualization

PROJECT_TITLE: UCLA IDDRC: Cells, Circuits and Systems Core


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Hematology;Infectious Diseases;Lung;Pediatric;Sepsis

PHR: PROJECT NARRATIVE - University of California Consortium The Eunice Kennedy Shriver National Institutes of Child Health and Development (NICHD) Collaborative Pediatric Critical Care Research Network (CPCCRN) was established in 2004 to address the need for carefully planned and well designed, prospective, multicenter clinical trials for infants and children with Critical Illness. This proposal seeks to establish a University of California Consortium (UCC) hub site consisting of UCSF Benioff Children Hospital's at San Francisco and Oakland along with UCLA Mattel Children's Hospital. UC Davis will join the UCC as ancillary site, allowing us to participate fully in the “Personalized Immunomodulation in Sepsis-induced MODS” trial described in this application.

PI_NAMEs: MCQUILLEN, PATRICK SEAN (contact)

PROJECT_TERMS: Address;Admission activity;Ancillary Study;Award;Beds;Biological Markers;Brain Injuries;California;Child;Child Development;Child Health;Childhood;Clinical;Clinical Research;clinical research site;Clinical Trials;Coagulation Process;Collaborations;Contracts;Critical Care;Critical Illness;Data;Data Coordinating Center;Databases;design;early-career faculty;Ethnic Origin;expectation;experience;Faculty;Family;Funding;Gene Expression;Geography;Goals;Good Clinical Practice;Health;Hypoxemic Respiratory Failure;Immune response;Immunocompromised Host;immunoregulation;Individual;Infant;Inflammation;innovation;Lead;Los Angeles;Lung;lung microbiome;Machine Learning;Manuscripts;meetings;Mentors;metabolomics;metatranscriptomics;Morbidity - disease rate;mortality;Multi-Institutional Clinical Trial;National Heart, Lung, and Blood Institute;Natural Language Processing;Network Infrastructure;Nurses;Obesity;Outcome;outcome prediction;participant enrollment;Pediatric Acute Lung Injury;Pediatric Hospitals;pediatric sepsis;Performance;Physiology;Population;Procedures;Productivity;programs;prospective;Protocols documentation;Publishing;racial diversity;Recording of previous events;Research;Research Personnel;Research Training;Respiratory Failure;Risk;San Francisco;Scientist;Sepsis;Site;success;Talents;United States National Institutes of Health;Universities;ward;Work

PROJECT_TITLE: Collaborative Pediatric Critical Care Research Network - Clinical Site


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Bioengineering;Nanotechnology

ORG_CITY: Princeton

ORG_DEPT: CHEMISTRY

ORG_NAME: PRINCETON UNIVERSITY

ORG_STATE: NJ

PHR: Project Narrative  Photon-driven chemical reactions can enable the synthesis of complex, biologically relevant molecules, important in the pharmaceutical industry. However, many reactions commonly used to build molecules rely on bulk heating to break strong chemical bonds. This proposal will leverage an underused light-to-heat conversion strategy to avoid the energy intensive and inefficiencies associated with bulk heating. The success of the proposed research will ultimately enable new methods in organic synthesis for building complex molecules using energy efficient visible light.

PI_NAMEs: STACHE, ERIN  (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TERMS: Area;Biochemical Reaction;Carbon;Catalysis;catalyst;chemical bond;chemical reaction;Chemicals;Complex;Coupling;Cyclization;design;Drug Industry;Dyes;Emulsions;energy efficiency;epimerization;experience;forging;Generations;Heating;High temperature of physical object;Intercept;irradiation;Kinetics;Light;light effects;Methods;Micelles;Molecular;nanometer;nanoparticle;Organic Synthesis;Pharmacologic Substance;Photons;Process;Reaction;Research;Resolution;Side;success;Temperature;tool;Visible Radiation

PROJECT_TITLE: Photothermal Catalysis: Using light to thermally generate reactive intermediates with temporal and spatial control


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Brain Disorders;Disability Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PI_NAMEs: BUTLER, SAMANTHA J (contact)

PROJECT_TERMS: 3-Dimensional;Affect;animal imaging;Animal Model;Animals;Axon;Biological;Biological Models;Biological Process;Brain;brain circuitry;Brain region;Cell Culture Techniques;Cell Physiology;Cells;cognitive neuroscience;community center;Complex;Coupled;Data;Dedications;Dendrites;Developmental Disabilities;developmental disease;Disability research;Disease;Environment;fluorescence microscope;Fluorescence Microscopy;Gene Expression Profiling;Generations;Genetic;holistic approach;Human;Image;imaging facilities;Implant;improved;In Vitro;in vivo imaging;Intellectual and Developmental Disabilities Research Centers;Laboratories;Learning;Light;Light Microscope;light microscopy;Magnetic Resonance Imaging;member;Memory;Methodology;Methods;Microscope;Microscopy;miniaturize;Modality;Modeling;Molecular Probes;Mus;nervous system development;Nervous System Physiology;neural circuit;neuroimaging;Neurons;new technology;next generation;novel;novel imaging technology;open source;optical imaging;Optics;optogenetics;Organ;Organoids;Patients;Pattern;Photons;Population;Protocols documentation;Recording of previous events;Research;Research Personnel;Research Support;Resolution;Resources;Rodent;Rodent Model;Role;Sampling;Scientist;Services;Sleep disturbances;Spectrum Analysis;Stem Cell Research;stem cells;Structure;submicron;Techniques;Technology;Therapeutic Intervention;Tissues;Translating;two-photon;Visual Acuity;Visualization;voucher;Work

PROJECT_TITLE: UCLA IDDRC: Structural and Functional Visualization Core


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Biomedical Imaging;Cancer;Climate-Related Exposures and Conditions;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Skin Cancer;Wound Healing and Care

ORG_CITY: DAYTON

ORG_DEPT: PHARMACOLOGY

ORG_NAME: WRIGHT STATE UNIVERSITY

ORG_STATE: OH

PHR: RATIONALE The goal of the project described in this revised proposal is to extend our ongoing clinical trials to determine whether wounding of aged skin can prevent the occurrence of non-melanoma skin cancers. Furthermore, studies are designed to examine the mechanisms responsible for wounding-induced protection from ultraviolet- light induced skin cancer, namely, how new fibroblasts populate aged skin in response to wounding. Finally, these studies will test a novel non-invasive imaging platform designed to predict skin cancer occurrence.

PI_NAMEs: SPANDAU, DAN F;TRAVERS, JEFFREY B. (contact)

PROGRAM_OFFICER_NAME: SAZONOVA, IRINA Y

PROJECT_TERMS: Actinic keratosis;Acute;Aftercare;Age;age related;aged;cancer diagnosis;carcinogenesis;carcinogenicity;Chemopreventive Agent;Clinical Trials;Compensation;Data;Dermabrasion;Dermal;Dermis;design;Disease;DNA Damage;DNA Repair;Elderly;Ensure;Environmental Risk Factor;epidemiologic data;Epidermis;Exposure to;Fibroblasts;Financial Hardship;Forearm;genome-wide analysis;Genotoxic Stress;Goals;Grant;Healthcare Systems;high risk;Human;imaging platform;In Vitro;in vivo;Incidence;Individual;Induction of Apoptosis;Insulin-Like Growth Factor I;Insulin-Like-Growth Factor I Receptor;Intervention;irradiation;keratinocyte;Knowledge;Laboratories;Lasers;Longevity;Malignant Neoplasms;Mediating;Monitor;Neoplasms;neoplastic cell;non-invasive imaging;novel;novel imaging technology;novel therapeutic intervention;Outcome Study;Patients;Population;Populations at Risk;Postmenopause;Predisposition;premalignant;prevent;Process;Production;Productivity;Proliferating;prophylactic;Publishing;Receptor Activation;Receptor Signaling;recruit;Rejuvenation;repaired;response;Risk;Risk Factors;Role;senescence;single-cell RNA sequencing;Skin;Skin Aging;skin barrier;Skin Cancer;Skin Carcinoma;skin wound;Source;Sunlight;Survival Rate;Testing;Therapeutic;Therapeutic Intervention;transcriptomics;Tumor Escape;ultraviolet;Ultraviolet B Radiation;Underserved Population;United States;UV carcinogenesis;UV induced;UV protection;UVB induced;Women's study;wound;wound treatment;Wrist

PROJECT_TITLE: Wounding Therapy and Photocarcinogenesis

STUDY_SECTION: ACTS

STUDY_SECTION_NAME: Arthritis, Connective Tissue and Skin Study Section[ACTS]


PHR: PROJECT NARRATIVE - University of Minnesota This proposal is relevant to public health because the University of Minnesota Masonic Children's Hospital and our ancillary site, Children's Minnesota, will enroll children from a variety of social, economic, and racial backgrounds from throughout the Upper Midwest to CPCCRN studies. The proposed project investigates the impact of individual immune function profiles and treatment on organ dysfunction from sepsis and whether treated children recover more fully following their illness and therefore requires a diverse patient population to adequately address this personalized question. UMMCH's role as a clinical site is relevant to the NICHD CPCCRN's mission to care for all critically ill and injured children, and to reduce the impact of illness and disability on every child.

PI_NAMEs: STEINER, MARIE E (contact)

PROJECT_TERMS: Address;Admission activity;Advisory Committees;ancillary care;Anti-Inflammatory Agents;Applied Skills;Asian population;base;Beds;Bioinformatics;Cardiac;Caring;Child;Child Health;Child health care;Childhood;Childhood Injury;Clinical;clinical center;Clinical Research;clinical research site;Clinical Trials;Collaborations;Collection;Communicable Diseases;Communities;Complement;Contracts;Critical Care;Critical Illness;Critically ill children;Data;Data Coordinating Center;Dedications;Development;Devices;dietary;disability;Discipline of Nursing;Doctor of Philosophy;Ebola;Ebola virus;Economics;Enrollment;Ethics;Ethnic Origin;expectation;experience;Faculty;Family;Fellowship;forging;Functional disorder;Future;Good Clinical Practice;Grant;Granulocyte-Macrophage Colony-Stimulating Factor;Health;health care service organization;health related quality of life;Hematology;Illness impact;immune function;Immunophenotyping;immunoregulation;immunosuppressed;Individual;industry partner;innovation;Institution;interest;International;Intubation;Knowledge;knowledge base;Leadership;Manuscripts;Measures;Medical;Medicine;meetings;member;Mentors;Mentorship;Midwestern United States;Minnesota;Mission;Multicenter Trials;Multiple Organ Failure;National Institute of Child Health and Human Development;Native Americans;Nosocomial Infections;Observational Study;Oncology;Operative Surgical Procedures;Organ;Organ Donations;Organ Transplantation;organizational structure;Outcome;participant enrollment;pathogen;patient population;Patient Recruitments;Patients;Pediatric Acute Lung Injury;pediatric department;Pediatric Hospitals;Pediatric Intensive Care Units;pediatric sepsis;Pennsylvania;Performance;Pharmacologic Substance;Pharmacy facility;Population;Positioning Attribute;Prevention;Principal Investigator;Procedures;product development;Protocols documentation;Public Health;Race;Recording of previous events;Recovery;Registries;Research;Research Personnel;Research Training;Respiratory Therapy;Role;Running;sample collection;Scientist;Sepsis;Services;severe injury;Site;skills;social;Socioeconomic Status;socioeconomics;southeast Asian;success;surgical service;System;Talents;Time;Training;Translational Research;translational study;Trauma;treatment center;United States;Universities;University resources;venous thromboembolism;Work


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

ORG_CITY: Newark

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

PHR: Overall – Narrative Despite the rapidly growing US Asian population, there are vast gaps in translational research on comorbid cardiometabolic and mental health outcomes. In the Rutgers-NYU Center for Asian Health Promotion and Equity, we will establish three complementary cores and three research projects to achieve the mission of the center: to improve cardiometabolic and mental health of US Asians through a robust research infrastructure and resource structure and developing the next generation of scientists focused on these health disparity issues.

PI_NAMEs: SETOGUCHI IWATA, SOKO  (contact);WU, BEI

PROGRAM_OFFICER_NAME: STINSON, NATHANIEL

PROJECT_TERMS: Academic achievement;Achievement;Adult;Advisory Committees;Affect;Aging;Asian;Asian population;Biomedical Research;Body mass index;Cardiometabolic Disease;cardiometabolism;caucasian American;Clinical Research;Clinical Trials;college;Communication;Communities;community engagement;community partnership;community-centered;comorbidity;cultural values;Data;dementia caregiving;design;Development;Discipline;disorder prevention;Disparity;Distress;Enrollment;Ensure;Environment;Evaluation;expectation;experience;Family;Feeling hopeless;Fostering;Funding;Future;Goals;Health;health disparity;health equity;Health equity research;health inequalities;Health Promotion;Heart;help-seeking behavior;Heterogeneity;high risk;Immigrant;Immigration;improved;Income;Infrastructure;Institution;institutional capacity;Interdisciplinary Study;Intervention;Intervention Studies;Language;Leadership;Mental Depression;Mental Health;Methods;Mind;Minority;Minority Groups;Minority Health Research;Minority-Serving Institution;Mission;Modeling;multidisciplinary;multiple chronic conditions;Nature;next generation;nutrition;Nutritional;Obesity;older adult;Outcome;Overweight;Participant;Persons;Pilot Projects;Policies;Population;Population Growth;population health;Population Heterogeneity;Poverty;Precision Health;Preparation;Prevention;programs;Recommendation;Records;Religion;Research;Research Infrastructure;Research Personnel;Research Project Grants;Research Support;Resources;response;Science;Scientist;sexual identity;Spirituality;Stereotyping;Structure;success;Suicide attempt;Surveys;System;Testing;theories;tool;translational impact;Translational Research;trauma exposure;United States National Institutes of Health;Work


NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: DONG, XINQI  (contact)

PROJECT_TERMS: Advisory Committees;Asian;Asian population;Benchmarking;Cardiometabolic Disease;cardiometabolism;career;Collaborations;Communication;Communities;community advisory board;community engagement;Data;data harmonization;design;Development;Disease Outcome;disorder prevention;Ensure;Environment;environmental enrichment for laboratory animals;Evaluation;experience;Faculty;Feedback;Fostering;health disparity;health equity;Health equity research;Health Promotion;improved;Individual;Infrastructure;Institution;institutional capacity;Interdisciplinary Study;Intervention;Leadership;lens;member;Mental Health;Mentorship;Methodology;Mission;multidisciplinary;National Institute on Minority Health and Health Disparities;Outcome;Pilot Projects;Play;Policies;population health;Prevention;Productivity;programs;Recommendation;Records;recruit;Research;research and development;Research Personnel;Research Project Grants;Resources;Role;Science;success;Talents;Time;translational impact;Translational Research;Vision;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Health Services;Hematology;Infectious Diseases;Pediatric;Sepsis

PHR: PROJECT NARRATIVE – Nationwide Children’s Hospital This project is relevant to public health because, as one of the nation’s largest children’s hospitals, Nationwide Children’s Hospital has the patient population, research infrastructure, and investigator expertise to contribute fundamentally to our understanding the pathophysiology and treatment of pediatric critical illness. In particular, we expect the “Personalized Immunomodulation in Sepsis-Induced MODS” study to improve the survival of children with sepsis-induced MODS and to improve their functional status and quality of life.

PI_NAMEs: HALL, MARK W (contact)

PROJECT_TERMS: Admission activity;African American;anakinra;Ancillary Study;Anti-Inflammatory Agents;Aptitude;Beds;Belief;Biological;Biological Markers;Caring;Catchment Area;Caucasians;Censuses;Child;Child Care;Childhood;Clinical;clinical center;Clinical Research;clinical research site;Clinical Trials;Collaborations;Contracts;Critical Care;Critical Illness;Critically ill children;Data;Data Coordinating Center;Dedications;design;Development;Diagnostic Reagent Kits;Double-Blind Method;Enrollment;expectation;experience;Faculty;Functional disorder;functional status;Funding;Generations;Goals;Good Clinical Practice;Granulocyte-Macrophage Colony-Stimulating Factor;health related quality of life;Hispanic;Immune;immune function;Immune response;Immunologic Adjuvants;Immunologic Monitoring;Immunologic Surveillance;Immunologic Tests;Immunologics;Immunophenotyping;immunoregulation;Immunosuppression;improved;In Situ;Individual;Inflammation;Infrastructure;innovation;Inpatients;Institution;Intervention;Knowledge;Laboratories;Laboratory Research;Laboratory Study;Leadership;Medicine;meetings;member;Mentors;Mentorship;Monitor;Morbidity - disease rate;mortality;Multicenter Studies;multidisciplinary;Nurses;Ohio;patient oriented;patient population;Patients;Pediatric Hospitals;Pediatric Intensive Care Units;pediatric sepsis;Performance;Pharmaceutical Preparations;Pharmacy facility;Phenotype;Placebos;Population;primary outcome;Procedures;prospective test;Protocols documentation;Public Health;Quality of life;Randomized;randomized placebo-controlled clinical trial;Recording of previous events;Recovery;Research;Research Infrastructure;Research Institute;Research Personnel;Resources;restoration;Role;safety and feasibility;Scientist;secondary outcome;Sepsis;Site;Standardization;Steel;systemic inflammatory response;Talents;Time;tocilizumab;Translational Research;United States National Institutes of Health


NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Prevention;Racial and Ethnic Minority Health Research

PROJECT_TERMS: Address;Adoption;Adult;Aging;Applications Grants;Asian;Asian Americans;Asian population;cardiometabolism;Clinical;Clinical Research;Collaborations;collaborative environment;Communities;community based participatory research;community engagement;community partners;Community Practice;community setting;comorbidity;design;Development;disorder prevention;Ensure;environmental enrichment for laboratory animals;Evaluation;experience;Faculty;Fostering;Funding;Funding Mechanisms;Future;Goals;Health;health equity;Health equity research;Health Policy;Health Promotion;improved;Infrastructure;innovation;Institution;Interdisciplinary Study;Intervention;Intervention Studies;Leadership;Link;Mental Health;Mentorship;Methods;New Jersey;Outcome;Pathway interactions;Personal Satisfaction;Pilot Projects;Policies;Population;population health;Population Heterogeneity;practice setting;Precision Health;Preparation;Prevention;Process;programs;Publications;Recording of previous events;Research;Research Design;Research Infrastructure;Research Personnel;Resources;Science;Scientist;success;Syndrome;Translating;translational health science;Translational Research;translational research program;user-friendly;Work

PROJECT_TITLE: Investigator Development Core


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Genetics;HIV/AIDS;Human Genome;Infectious Diseases;Mental Health;Neurodegenerative;Neurosciences;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: LA JOLLA

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

PHR: Public Health Relevance Opioid abuse in HIV-infected individuals is associated with treatment non-compliance, greater risk of viral transmission, and more rapid disease progression. To investigate the molecular mechanisms behind the interactions of HIV and opioid use disorder (OUD), this interdisciplinary project will profile gene expression at the single cell level in key brain regions relevant to the effects of persistent HIV infection and OUD in a small animal model of neuroHIV in a behavioral paradigm of voluntary intravenous drug self-administration. We will bring to bear computational methods to elucidate the key genes driving the altered gene expression at the single cell level, which will provide a framework for new testable hypotheses on the mechanisms underlying the neuropathogenesis of the neuronal damage and neuroinflammation in the context of OUD in HIV infection that can reveal new pathogenic concepts and more effective therapeutic targets to improve neuropsychological functioning in people with HIV and OUD comorbidity.

PI_NAMEs: SANNA, PIETRO P (contact)

PROGRAM_OFFICER_NAME: SATTERLEE, JOHN S

PROJECT_TERMS: Abstinence;Address;Adopted;Alzheimer's Disease;Animal Model;Astrocytes;Automobile Driving;Behavior;Behavioral Paradigm;Binding;Brain region;Cell Nucleus;cell type;Cells;Central Nervous System;Chronic;Clinical;comorbidity;Complement;Computing Methodologies;Consultations;Data;Data Coordinating Center;Dependence;design;Development;Disease;Disease Progression;Dissection;Drug abuse;Drug Addiction;drug mechanism;Drug usage;DSM-IV;experience;Fentanyl;Freezing;Funding;Gene Expression;gene network;gene regulatory network;General Population;Genes;genetic signature;genome-wide;Genomics;Head;Heroin;HIV;HIV Infections;HIV-1;Human;human model;Impaired cognition;improved;Individual;Intake;Intravenous;Lymphocyte;Macrophage;Malignant Neoplasms;Methamphetamine;Methods;Microglia;Modeling;Molecular;Molecular Analysis;Molecular Profiling;Motivation;National Institute of Drug Abuse;negative emotional state;Negative Reinforcements;Nerve Degeneration;nerve injury;neuroAIDS;Neuroglia;neuroinflammation;Neurons;Neuropathogenesis;Neuropsychology;Neurosciences;new therapeutic target;non-compliance;novel therapeutics;Opioid;opioid abuse;opioid injection;opioid use;opioid use disorder;Oxycodone;oxycodone self-administration;Pathogenesis;Pathogenicity;Pattern;Persons;Pharmaceutical Preparations;prevent;programs;Proteins;public health relevance;public repository;Rat Transgene;Rattus;reconstruction;Recording of previous events;Recreation;Regulator Genes;Research Personnel;Resources;Risk;Rodent Model;Sampling;Self Administration;single cell analysis;single nucleus RNA-sequencing;Source;Substance abuse problem;Substance Use Disorder;Synapses;synergism;Systems Biology;Testing;Therapeutic;therapeutic target;therapeutically effective;Tissues;Transcript;transcriptome sequencing;transcriptomics;Transgenes;Transgenic Organisms;validation studies;viral transmission;Virus

PROJECT_TITLE: Single nucleus gene expression in moderate and compulsive opioid self-administration in a rodent model of HIV


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: PROJECT NARRATIVE Although there are thousands of genetic variations that are associated with human diseases, the underlying mechanisms of how these variants contribute to disease pathogenesis remain obscure. In this proposal, we will use a combination of high throughput genomics assays and CRISPR-based technologies to identify functional regulatory elements and the novel regulators for 3D genome organization. We will investigate how genetic variants can affect the function of regulatory elements and alter chromatin interactions and eventually contribute to human diseases.

PI_NAMEs: YUE, FENG  (contact)

PROJECT_TERMS: 3-Dimensional;Address;Affect;Biological Assay;ChIP-seq;Chromatin;Chromatin Interaction Analysis by Paired-End Tag Sequencing;Chromatin Loop;chromosome conformation capture;cohesin;Complex;Computer Models;CRISPR/Cas technology;Disease;Distal;DNase I hypersensitive sites sequencing;Enhancers;epigenome;experimental study;Gene Expression Regulation;Genes;Genetic study;genetic variant;Genetic Variation;Genome;genome editing;genome-wide;Genomics;Goals;Hi-C;high throughput screening;Higher Order Chromatin Structure;histone modification;human disease;Human Genome;insight;Link;Measures;Methods;Molecular;multidisciplinary;novel;Pathogenesis;Regulatory Element;Reporter Genes;Technology;Training;transcription factor;Transgenic Organisms;Untranslated RNA;Variant;Work

PROJECT_TITLE: High throughput interrogation of non-coding variants and 3D genome organization


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Hematology;Infectious Diseases;Pediatric;Prevention;Sepsis

PHR: PROJECT NARRATIVE – University of Pittsburgh Medical Center Review of 109 million death records from the Global Burden of Disease study (1991-2017) found that one in five people in the world die from sepsis caused by overwhelming infection, with the majority of these being children. The new Eunice Kennedy Shriver NICHD Collaborative Pediatric Critical Research Network comprised of 12 primary sites and 12 ancillary sites proposes to perform a placebo controlled randomized trial to test the hypothesis that personalized utilization of molecular biology revolution breakthrough diagnostics and recombinant therapies to improve a child’s ability to fight infection and control inflammation will reduce this public health burden.

PI_NAMEs: CARCILLO, JOSEPH A (contact)

PROJECT_TERMS: Accounting;Acute Renal Failure with Renal Papillary Necrosis;Admission activity;anakinra;Anti-Inflammatory Agents;Biological Markers;Blinded;Blood;Brain Injuries;burden of illness;Cessation of life;Child;Child Development;Child Health;Childhood;Cities;Clinical Research;clinical research site;Clinical Trials;Clinical Trials Data Monitoring Committees;Collaborations;Contracts;Critical Care;Critical Illness;Critically ill children;Data;Data Coordinating Center;Death Records;design;Development;Diagnostic;Double-Blind Method;Enhancers;Enrollment;expectation;experience;Faculty;feasibility trial;fighting;fitness;Functional disorder;Funding;Futility;Future;Genetic;Genetic study;Goals;Good Clinical Practice;Heart Arrest;Immune;Immunologic Monitoring;immunoregulation;improved;Individual;Infant;Infection;Inflammation;innovation;Interleukin-6;Kansas;Kidney;Laboratories;Liquid substance;Manuscripts;Masks;Medical center;meetings;member;Mentored Clinical Scientist Development Program;Mentors;Mentorship;Molecular Biology;Monoclonal Antibodies;Morbidity - disease rate;mortality;Multiple Organ Failure;National Institute of Diabetes and Digestive and Kidney Diseases;National Institute of General Medical Sciences;National Institute of Neurological Disorders and Stroke;next generation;Nurses;Organ;Outcome;Parental Consent;participant enrollment;pathogen;Patients;Pediatric Hospitals;pediatric sepsis;Peer Review;Performance;Persons;Phenotype;Placebos;Population;Positioning Attribute;Principal Investigator;Procedures;Productivity;Protocols documentation;Public Health;Publishing;Randomized;randomized placebo controlled trial;Recombinant Granulocyte-Macrophage Colony-Stimulating Factors;Recombinant Interleukin-1;Recombinants;Research;Research Personnel;Research Training;Resuscitation;Role;Scientist;Sedation procedure;Sepsis;Site;Study Section;success;Syringes;Talents;Technology;Testing;treatment as usual;trial planning;Universities;Work


ADMINISTERING_IC: DK

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Cystic Fibrosis;Diabetes;Genetics;Lung;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: ATLANTA

ORG_DEPT: NUTRITION

ORG_NAME: GEORGIA STATE UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative Cystic Fibrosis (CF) is the most common lethal genetic disease in US Caucasians, arising from mutations in the gene encoding CF transmembrane conductance regulator (CFTR). CF-related diabetes (CFRD), the most prevalent co-morbidity, develops at the early age of childhood. The proposal will help to understand the pathogenesis in the pancreas during the development of CFRD, and to provide all people with CF the opportunity to lead long, fulfilling lives.

PI_NAMEs: JI, XIANGMING  (contact)

PROGRAM_OFFICER_NAME: EGGERMAN, THOMAS L

PROJECT_TERMS: Adipocytes;Adult;Age;Alpha Cell;Animal Model;Bacterial Infections;Beta Cell;Biological Markers;career;Caucasians;Cause of Death;Cell Death;Cell Line;Cell Physiology;Cell Survival;Cells;Childhood;Collagen;comorbidity;Cystic Fibrosis;cystic fibrosis patients;cystic fibrosis related diabetes;Cystic Fibrosis Transmembrane Conductance Regulator;D Cells;Death Rate;Delta F508 mutation;Development;Diabetes Mellitus;diabetic;diagnostic strategy;Disease;Early Diagnosis;effective therapy;Endocrine;endoplasmic reticulum stress;epithelial Na+ channel;Exhibits;Exocrine pancreas;experience;FDA approved;Ferrets;Fibrosis;Functional disorder;Future;gastrointestinal system;Gene Expression;Genes;Genetic Diseases;Genetic Transcription;Glucagon;Goals;Homeostasis;Human;human pluripotent stem cell;humanized mouse;imaging approach;Imaging Techniques;impaired glucose tolerance;In Vitro;in vitro testing;in vivo;in vivo evaluation;Infiltration;Inflammation;Insulin;islet;Islet Cell;Islets of Langerhans;Knockout Mice;Knowledge;Lead;Learning;Life;Location;Lung;Lung Diseases;Magnetic Resonance Imaging;Maps;member;Metallothionein;Methods;Modeling;Molecular;Molecular Genetics;Monitor;Morbidity - disease rate;mouse model;Mucous body substance;Mus;mutant;Mutation;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutics;Obstructive Lung Diseases;Organoids;overexpression;Oxidation-Reduction;Pancreas;Pathogenesis;Pathologic;Pathology;Pathway interactions;Patients;Pattern;Persons;Pharmaceutical Preparations;Phenotype;Pluripotent Stem Cells;Pre-Clinical Model;Prevention;Production;programs;pulmonary function;Recovery;Research;Resolution;Role;Route;Severities;Signal Transduction;single-cell RNA sequencing;Somatostatin;Streptozocin;Structure of beta Cell of islet;systemic inflammatory response;Techniques;Testing;Time;Tissues;treatment strategy;VX-770;Zinc

PROJECT_TITLE: Role of Metallothionein 1 E in the protection of cystic fibrosis-related diabetes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-EMS-L(02)M]


NIH_SPENDING_CATS: Cancer;Hematology;Immunotherapy;Orphan Drug;Precision Medicine;Radiation Oncology;Rare Diseases

ORG_CITY: DUARTE

ORG_NAME: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE

PHR: PROJECT NARRATIVE The contributions of the Research Scientist are relevant to public health because the identification of effective combinatorial therapeutic regimens for multiple myeloma, with correlative studies leading to the discovery of new drug targets, is expected to lead to novel therapies for this currently incurable malignancy. Thus, the goals are relevant to the part of the NIH's mission that pertains to fostering discoveries as a basis of improving health.

PI_NAMEs: CASERTA, ENRICO  (contact)

PROGRAM_OFFICER_NAME: HENDERSON, LORI A

PROJECT_TERMS: adhesion receptor;Affect;anti-cancer research;Anti-viral Response;cancer cell;Cancer Patient;Cells;chimeric antigen receptor T cells;clinical effect;combinatorial;Communities;Correlative Study;Disease;Disease remission;Disease Resistance;Dose;experience;Family;Fostering;Funding;Generations;Goals;Health;Hematopoietic Neoplasms;Histone Deacetylase Inhibitor;immune modulating agents;immunoregulation;improved;improved outcome;In Vitro;Infection;Isotopes;Laboratories;Leflunomide;lenalidomide;Malignant Neoplasms;Mission;Multiple Myeloma;National Cancer Institute;new therapeutic target;novel therapeutic intervention;novel therapeutics;Oncornaviruses;Oral;Patients;Persons;Pharmaceutical Preparations;Phosphotransferases;Proteasome Inhibitor;Protein-Serine-Threonine Kinases;Proto-Oncogene Proteins c-myc;Public Health;Qualifying;Radioimmunotherapy;receptor;Regimen;Relapse;relapse risk;Research;resistance mechanism;Rheumatoid Arthritis;Scientist;Serine;side effect;Specialist;Surface;Therapeutic;Therapeutic Uses;Tumor Burden;United States;United States National Institutes of Health;Work

PROJECT_TITLE: Improving Outcomes for Multiple Myeloma Patients through Novel Therapeutic Interventions


NIH_SPENDING_CATS: Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: GAUR, SUNANDA  (contact)

PROJECT_TERMS: Adult;Asian;Asian Americans;Asian population;Behavioral Research;Biomedical Research;Cardiometabolic Disease;cardiometabolism;caucasian American;Chronic;Communication;communication theory;Communities;community academic partnership;community based participatory research;community engaged research;community engagement;community partners;community partnership;comorbidity;Development;Disparity;disparity reduction;Dissemination and Implementation;Distress;empowerment;Enrollment;Environment;Equity;Ethnography;evidence base;experience;Faculty;Funding;Goals;Health;health disparity;health equity;Health Promotion;improved;Income;Infrastructure;Institution;Intervention Studies;Knowledge;Linguistics;literacy;member;Mental Health;Minority Groups;National Institute on Minority Health and Health Disparities;New Jersey;New York;news;older adult;Outcome;Policies;Policy Maker;Population;Population Research;Poverty;psychosocial;recruit;Research;research and development;Research Personnel;Research Project Grants;Risk;Risk Factors;social;social culture;support tools;Time;Training and Education;Translating;Translational Research;United States National Institutes of Health;Workforce Development

PROJECT_TITLE: Community Engagement Core


NIH_SPENDING_CATS: Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Hematology;Infectious Diseases;Pediatric;Sepsis

PHR: PROJECT NARRATIVE – Children’s National Hospital Pediatric sepsis and multiple organ failure are identified as conditions that adversely affect the public health of children by NICHD, leading to increased mortality and morbidity. Beside supportive care with antibiotics, resuscitative measures to augment oxygen delivery and mechanical support for failing organs, no therapies have been identified to decrease the burden of illness for children with multiple organ dysfunction syndrome (MODS). In this new application, the Collaborative Pediatric Critical Care Research Network will perform two randomized controlled trials to determine whether immunomodulation after sepsis-induced MODS decreases organ failure and improves outcomes.

PI_NAMEs: BELL, MICHAEL J (contact)

PROJECT_TERMS: Acute;Admission activity;Affect;Antibiotics;Area;Ascorbic Acid;Biological Markers;Brain;burden of illness;Cardiac;career;Chest;Child;Child Development;Child Health;Childhood;clinical care;clinical center;Clinical Research;clinical research site;Clinical Trials;Collaborations;Communities;Contracts;Critical Care;Critical Illness;Critically ill children;Data;Data Coordinating Center;Delirium;design;Development;disability;District of Columbia;Enrollment;Ensure;expectation;experience;Faculty;Family;functional outcomes;functional status;Funding;Goals;Good Clinical Practice;Guideline Adherence;Health;health assessment;health related quality of life;Healthcare Systems;Hospitals;Human Resources;Hypoxemic Respiratory Failure;immunoregulation;improved;improved outcome;Individual;Inflammation;Injury;innovation;Institution;Lead;Maryland;Measures;Mechanics;Medicine;meetings;member;Morbidity - disease rate;mortality;Multicenter Studies;Multiple Organ Failure;Neurologic;Nitric Oxide;novel strategies;novel therapeutic intervention;Observational Study;Organ;Organ failure;Outcome;outcome prediction;Oxygen;participant enrollment;Patient Care;Patients;Pediatric Hospitals;pediatric sepsis;pediatric trauma;pediatric traumatic brain injury;Performance;Personal Satisfaction;personalized medicine;Principal Investigator;Procedures;Productivity;Protocols documentation;Public Health;Quality of life;Randomized, Controlled Trials;Recovery;Research;Research Personnel;Research Proposals;research study;Research Training;Resources;Running;Scientist;Sedation procedure;Sepsis;Sickle Cell Anemia;Site;skills;Sleep;Specialist;Standardization;success;Supportive care;systematic review;T cell regulation;Talents;Testing;Training;Traumatic Brain Injury;Virginia;Washington;Work


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Microbiome;Nutrition;Obesity;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Sleep Research;Social Determinants of Health

PI_NAMEs: BYRD-BREDBENNER, DEBRA CAROL (contact)

PROJECT_TERMS: 2 arm randomized control trial;Address;Adopted;Adult;Anti-Inflammatory Agents;Asian;Asian population;Attenuated;Awareness;Bacteria;Behavior;Behavior Therapy;Behavioral;Body mass index;Cardiometabolic Disease;cardiometabolic risk;cardiometabolism;Characteristics;China;Chinese;Chinese population;Chronic Disease;Clinical Trials;clinically significant;cognitive interview;community engaged approach;community-centered;comorbidity;Consumption;Country;culturally appropriate intervention;cytokine;Diabetes Mellitus;Diet;Dietary Fiber;Dietary intake;Dietary Intervention;Disease Progression;disorder risk;Disparity;efficacy testing;Endotoxins;Ethnic Origin;evidence base;Family;Fiber;Focus Groups;Food;Fruit;Glycosylated hemoglobin A;Goals;group intervention;gut bacteria;gut health;gut microbiome;gut microbiota;Health;Health behavior;health disparity;health equity;Health Food;health inequalities;Health Promotion;Health Status;healthy lifestyle;Home environment;Homeostasis;Hypertension;Immigration;improved;Individual;Inflammation;Inflammatory;informant;interest;Interruption;Intervention;Intervention Studies;Interview;Knowledge;Life Style;Linguistics;Link;Measures;microbiome;Minority Groups;Modeling;modifiable risk;multi-component intervention;National Institute on Minority Health and Health Disparities;New Jersey;New York;Noise;Non-Insulin-Dependent Diabetes Mellitus;nutrition;Nutritional;Obesity;obesity risk;Onset of illness;Outcome;Overweight;Participant;pathobiont;Patient Self-Report;Physical activity;physical inactivity;Physiological;Play;Populations at Risk;protective factors;Psychosocial Stress;Race;Randomized;Recommendation;Reporting;Research;Research Project Grants;Risk;Risk Factors;Role;Self Efficacy;Shapes;Sleep;sleep behavior;Sleep Deprivation;social cognitive theory;social health determinants;sociodemographics;Spanish/English;Spouses;sugar;systemic inflammatory response;Testing;Treatment Efficacy;treatment group;United States Department of Agriculture;United States Preventative Services Task Force;Vegetables;waist circumference;World Health Organization

PROJECT_TITLE: HomeStyles: Shaping HOME Environments and LifeSTYLE Practices to Reduce Cardiometabolic Disease Risk


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Emergency Care;Health Services;Stroke

ORG_CITY: Columbus

ORG_DEPT: NEUROLOGY

ORG_NAME: OHIO STATE UNIVERSITY

PHR: Project Narrative Dizziness is a common reason for visiting the emergency department (ED). Guideline-supported evidence- based practices exist but are substantially underused while many unnecessary tests are overused. The DIZZTINCT-2 study builds on the results of DIZZTINCT-1 and will evaluate the effect of an implementation strategy that focuses on evidence-based practices for dizziness visits and uses provider- and patient-oriented resources.

PI_NAMEs: KERBER, KEVIN ANTHONY (contact);MEURER, WILLIAM JOSEPH;NGUYEN, HUONG Q

PROGRAM_OFFICER_NAME: KING, KELLY ANNE

PROJECT_TERMS: Accident and Emergency department;Acute;Admission activity;Adverse event;Benign paroxysmal positional vertigo;California;Caring;Clinical;design;Diagnosis;disability;disabling symptom;Disease;dissemination strategy;Dizziness;E-learning;Education;Educational Materials;effectiveness evaluation;effectiveness/implementation trial;Emergency department visit;Equipment and supply inventories;evidence base;Evidence based practice;experience;Exposure to;follow-up;Frequencies;gaze;Guidelines;Head;Hybrids;implementation evaluation;implementation fidelity;implementation outcomes;implementation research;implementation strategy;improved;Incentives;Individual;innovation;Intervention;Interview;Learning;Length of Stay;Measures;Medicine;Nurses;Outcome;patient oriented;Patient-Focused Outcomes;Patients;Performance;Peripheral;Persons;Play;Positioning Attribute;post intervention;primary outcome;Process;programs;Provider;Randomized;randomized trial;randomized, clinical trials;Reminder Systems;Reporting;Research Personnel;Resources;Role;routine provider;Safety;scale up;Site;Stroke;stroke risk;Structure;Testing;Vestibular Diseases;Vestibular Neuronitis;Visit;Walking

PROJECT_TITLE: DIZZiness Treatment through ImplementatioN & Clinical strategy Tactics (DIZZTINCT-2) Project


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Hematology;Infectious Diseases;Pediatric;Sepsis

ORG_NAME: UNIVERSITY OF UTAH

PHR: PROJECT NARRATIVE – University of Michigan The incidences of some of the most challenging diseases that contribute to pediatric critical illness, notably acute respiratory distress syndrome and sepsis, are such that relying on any one center to execute a single- site study that will advance both our understanding and management of these diseases is ineffective. In order to improve the care of this vulnerable population of critically ill children, the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) has addressed this by funding an infrastructure for a multicenter research network, the Collaborative Pediatric Critical Care Research Network (CPCCRN) and the accompanying clinical trial examining the efficacy of GM-CSF in children with sepsis entitiled, Personalized Immunomodulation in Sepsis-induced Multiple Organ Dysfunction Syndrome (MODS). This application will position our Pediatric Critical Care Medicine Research Program at the University of Michigan and our ancillary site at the Pediatric Critical Care Division at the Medical College of Wisconsin to actively participate and contribute in this important national network.

PI_NAMEs: QUASNEY, MICHAEL W (contact)

PROJECT_TERMS: Address;Admission activity;Beds;Cardiac;Caring;Child;Child Development;Child Health;Childhood;Childhood Injury;clinical research site;Clinical Trials;Clinical Trials Network;Collaborations;Contracts;Critical Care;Critical Illness;Critically ill children;Data;Data Coordinating Center;Death Rate;Development;Disease;Disease Management;efficacy evaluation;expectation;Faculty;Funding;Goals;Good Clinical Practice;Granulocyte-Macrophage Colony-Stimulating Factor;Growth;Healthcare;immunoregulation;implementation science;improved;Incidence;Individual;Infrastructure;insight;Institution;interdisciplinary approach;interest;International;Leadership;Lung;Medical;medical schools;Medicine;meetings;member;Mentored Clinical Scientist Development Program;Mentors;Michigan;mindfulness;Multi-Institutional Clinical Trial;Multiple Organ Failure;National Heart, Lung, and Blood Institute;National Institute of Child Health and Human Development;neurodevelopment;novel;Outcome;Paper;participant enrollment;Pediatric Acute Lung Injury;Pediatric Acute Respiratory Distress Syndrome;Pediatric Hospitals;Performance;Population;Positioning Attribute;Principal Investigator;Procedures;Process;Program Development;programs;Protocols documentation;Publishing;Recording of previous events;Research;Research Personnel;Research Training;Resources;Sales;Scientist;Sepsis;sepsis induced ARDS;severe injury;Site;success;Talents;tertiary care;Training;Trauma;United States National Institutes of Health;Universities;Vision;Vulnerable Populations;Wisconsin;Work