ORG_CITY: WASHINGTON

ORG_NAME: GEORGE WASHINGTON UNIVERSITY

ORG_STATE: DC

PHR: Narrative HIV-infected individuals are at high risk of developing cardio-vascular disease (CVD), even when HIV infection is controlled by treatment. We hypothesize that susceptibility to CVD is promoted by the extracellular vesicles containing HIV protein Nef, which are released from HIV-infected cells and modify membranes of the cells related to CVD. We will investigate new treatments designed to reverse the effects of Nef on cell membrane.

PI_NAMEs: BUKRINSKY, MICHAEL ILYA (contact);SVIRIDOV, DMITRI

PROGRAM_OFFICER_NAME: HASAN, AHMED A  K

PROJECT_TERMS: Affect;antiretroviral therapy;Apolipoprotein A-I;Apolipoprotein E;Apoptosis;Atherosclerosis;Basic Science;Binding Proteins;Blood;Blood Cells;carbohydrate metabolism;Cardiac;Cardiometabolic Disease;cardiometabolism;Cardiovascular Diseases;Cell membrane;Cells;Cellular Metabolic Process;Chemosensitization;Cholesterol Homeostasis;comorbidity;Development;Disease;Elements;Exhibits;extracellular vesicles;high risk;HIV;HIV Infections;immunodeficiency;Impairment;in vivo;Individual;inflammatory marker;Inflammatory Response;Insulin Resistance;lipid metabolism;lipid transport;Lipids;Macrophage;Measures;Mediating;Membrane Microdomains;Metabolic;Metabolic Diseases;Methods;Modeling;Modification;monocyte;mouse model;Mus;Names;nef Protein;novel;novel therapeutic intervention;novel therapeutics;Pathogenesis;Pathogenicity;Pathologic;Pathway interactions;Peripheral Blood Mononuclear Cell;Persons;Phenotype;Plasma;Play;Predisposition;prevent;Property;recruit;Reporting;Role;Signal Transduction;Structure;targeted treatment;Testing;Therapeutic;therapeutic development;therapeutic target;therapy design;Transgenic Mice;Transgenic Organisms;translational impact;treatment strategy;vesicular release;Viral;Viral load measurement;Viral Load result;Viral Proteins;Viral reservoir;Virus

PROJECT_TITLE: Lipid raft therapy – a novel therapeutic approach for HIV-associated cardiometabolic co-morbidities

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


ADMINISTERING_IC: AR

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Biotechnology;Clinical Research;Genetics;Human Genome;Prevention;Rheumatoid Arthritis

ORG_CITY: BOSTON

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: Project Narrative Now that we have identified the key genetic loci that modulate rheumatoid arthritis (RA), we seek to define the mechanism by which these loci cause disease. Here we explore an innovative model of genetic susceptibility that links the role of the MHC and alleles within T cell regulatory regions. If our strategy is successful, it will pave the way to unlocking new therapeutic strategies to treat RA and possibly cure it.

PI_NAMEs: RAYCHAUDHURI, SOUMYA  (contact)

PROGRAM_OFFICER_NAME: WANG, YAN Z

PROJECT_TERMS: Affect;Alleles;Amino Acid Sequence;Amino Acids;analytical method;Antigens;ATAC-seq;Autoantigens;Autoimmune Diseases;Autoimmune Responses;Automobile Driving;BACH2 gene;base editing;Base Pairing;Binding;Biological Assay;Blood;causal variant;CCL21 gene;CD4 Positive T Lymphocytes;Cell Separation;Cells;Cellular Assay;Chromatin;cohort;comparison control;CTLA4 gene;Data;Disease;Disease susceptibility;DNA Sequence;Electrophoretic Mobility Shift Assay;Engineering;Enhancers;Funding;Gene Expression Regulation;Genes;Genetic;Genetic Engineering;Genetic Models;Genetic Predisposition to Disease;Genetic Risk;Genome;genome editing;genomic locus;Genotype;high dimensionality;HLA-DR Antigens;Human Genetics;IL2RA gene;Immune response;Individual;innovation;joint inflammation;Link;Luciferases;Maps;Mediating;Methodology;Modeling;Molecular;novel;novel therapeutic intervention;Nucleic Acid Regulatory Sequences;Pathogenesis;Pathogenicity;Peptides;Predisposition;prevent;promoter;protein biomarkers;Proteomics;receptor binding;Regulation;Regulatory Element;Regulatory T-Lymphocyte;Research Personnel;Rheumatoid Arthritis;Risk;Risk Assessment;risk variant;RNA;Role;Sentinel;single cell analysis;Site;Sorting;Specificity;Statistical Methods;Surface;Synovial Membrane;Synovitis;Systemic Lupus Erythematosus;T-cell inflamed;T-cell receptor repertoire;T-Lymphocyte;Technology;Therapeutic;Thymus Gland;Tissues;Transcript;transcriptome sequencing;transcriptomics;Transgenic Organisms;Untranslated RNA;Variant

PROJECT_TITLE: Defining the influence of RA genetic susceptibility factors on T cell antigen specificity and functional state

STUDY_SECTION: ACTS

STUDY_SECTION_NAME: Arthritis, Connective Tissue and Skin Study Section[ACTS]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;Infectious Diseases;Orphan Drug;Rare Diseases;Vector-Borne Diseases

ORG_DEPT: CHEMISTRY

ORG_NAME: NORTHEASTERN UNIVERSITY

PHR: NARRATIVE Human African trypanosomiasis and Chagas disease are classed as neglected tropical diseases by the World Health Organization. They suffer from a lack of financial investment from the for-profit pharmaceutical industry, yet current treatments are associated with limited efficacy, increasing instances of treatment failure, high cost and long-term toxicity issues. This project will focus on the development of compounds that meet the Target Product Profiles for the respective disease with the view of obtaining pre-clinical candidates and understanding the mode of action and/or identifying the target of lead series.

PI_NAMEs: FERRINS, LORI  (contact)

PROGRAM_OFFICER_NAME: JOY, DEIRDRE A

PROJECT_TERMS: Acute;Africa;African Trypanosomiasis;analog;Animals;Arginine;Asia;Biological Assay;blood-brain barrier crossing;blood-brain barrier permeabilization;Cells;Central America;Chagas Disease;Chemicals;Collaborations;Communicable Diseases;Complex;Computer Assisted;cost;Country;Cytochrome P450;Data;Development;Disease;disease model;Drug Combinations;drug discovery;Drug Industry;Drug Kinetics;drug metabolism;Ensure;Enzymes;experimental study;Fingerprint;follow-up;Funding;G-Protein-Coupled Receptors;Generations;Genetic;genome sequencing;Goals;Health;HepG2;high throughput screening;Human;in silico;in vivo;in vivo Model;Industrialization;Infection;inhibitor;interest;Investments;kinase inhibitor;Knock-out;Latin America;Lead;lead series;Life;Medicine;Metabolic;Modeling;Molecular Mechanisms of Action;mouse model;Mus;mutant;Nature;neglect;neglected tropical diseases;novel therapeutics;overexpression;Parasites;Parasitic Diseases;pathogen;Persons;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacologic;Pharmacotherapy;Phenotype;Phosphotransferases;population migration;pre-clinical;process optimization;Production;programs;Proliferating;Property;Proteomics;Recombinant Proteins;Resistance;response;Risk;Running;Series;side effect;Sorting;Source;Structure;synergism;Testing;Therapeutic Uses;Toxic effect;Treatment Failure;Treatment Protocols;Tropical Disease;Trypanocidal Agents;Trypanosoma brucei brucei;Trypanosoma cruzi;Validation;whole genome;Work;World Health Organization

PROJECT_TITLE: Repurposing human kinase inhibitor chemotypes for Neglected Tropical Diseases

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DDR-Y(07)S]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_CITY: NEW HAVEN

ORG_DEPT: PHYSIOLOGY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative Human signaling networks involve large sets of proteins exhibiting highly complex patterns of posttranslational modifications (PTMs) that govern their structure and function. Since changes in PTMs (e.g., phosphorylation and acetylation) occur at multiple sites, understanding such networks at the systems and mechanistic levels remains an elusive and unmet goal. This work seeks to develop new genomic and proteomic tools to encode multiple and programmable combinations of phosphorylated and acetylated amino acids into proteins that reveal new protein interactions at the molecular level to facilitate the development of new therapies for human disease.

PI_NAMEs: ISAACS, FARREN J.;RINEHART, JESSE  (contact)

PROGRAM_OFFICER_NAME: SIMONOVIC, MILJAN

PROJECT_TERMS: Acetylation;Amino Acids;Behavior;Binding Proteins;Biochemical;Biological Assay;Cell Physiology;Cells;Chemicals;Code;Codon Nucleotides;Complex;Data;Development;Disease;Enzymes;Escherichia coli;Essential Genes;Evolution;Exhibits;fitness;Foundations;Genetic;Genetic Code;genome editing;Genome engineering;Genomics;Goals;Human;human disease;Internet;Lysine;Mediating;Methods;Modality;Molecular;mutant;Names;new technology;new therapeutic target;novel;novel strategies;novel therapeutics;Organism;Pattern;Phosphoproteins;Phosphorylation;Phosphoserine;Physiological;Positioning Attribute;Post-Translational Protein Processing;protein activation;Protein Binding Domain;Protein Biosynthesis;protein complex;Protein Dynamics;Protein Engineering;protein protein interaction;Proteins;Proteome;Proteomics;Recombinant Proteins;Recombinants;reconstitution;Regulation;release factor;Research;Ribosomes;Scaffolding Protein;Series;Serine;Set protein;Signal Transduction;Site;Specificity;Structure;synthetic construct;System;Techniques;Technology;Terminator Codon;Testing;tool;Translations;Work;yeast two hybrid system

PROJECT_TITLE: Deciphering human signaling networks through synthetic activation of proteins in genomically recoded organisms with multiple open codons

STUDY_SECTION: GCAT

STUDY_SECTION_NAME: Genomics, Computational Biology and Technology Study Section[GCAT]


ADMINISTERING_IC: MH

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Pediatric;Physical Activity;Prevention;Psychosis;Schizophrenia;Serious Mental Illness;Social Determinants of Health;Telehealth

ORG_CITY: SEATTLE

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE  Coordinated specialty care for early psychosis shows significant promise to reduce long-term chronicity and dysfunction associated with schizophrenia-spectrum disorders, however, few young adults with early psychosis present to these services. Mobile health tools provide a unique opportunity to remotely engage this population and target help-seeking beliefs, but little is known about whether and how these approaches can address this gap. The proposed project aims to take a user-centered design approach to developing and testing an mHealth tool that promotes help seeking among young adults with early psychosis.

PI_NAMEs: BUCK, BENJAMIN EDWARDS (contact)

PROGRAM_OFFICER_NAME: SWEENEY, MARY MARGARET

PROJECT_TERMS: active control;Address;Area;Attitude;Award;barrier to care;Belief;Caring;Cellular Phone;Chronic;Cognitive Therapy;Communities;comparative efficacy;Computers;Coordinated Specialty Care;Data;Dedications;design;Detection;Development;Devices;digital health;digital tool;Distal;duration of untreated psychosis;Early Intervention;early psychosis;Ecological momentary assessment;efficacious intervention;Exercise;Exposure to;Family;Functional disorder;functional outcomes;Funding;Goals;Grant;handheld mobile device;Health;health literacy;Health Resources;Health Technology;help-seeking behavior;improved;Individual;innovation;interest;Internet;Intervention;Interview;K-Series Research Career Programs;Lead;Mental Depression;Mental Health;Mental Health Services;Mentorship;Methods;mHealth;mhealth interventions;mobile computing;Modeling;Motivation;National Institute of Mental Health;Outcome;Participant;peer;Persons;Pharmaceutical Preparations;Phase;Population;Predisposition;preference;premature;prevent;Prevention;primary outcome;programs;prototype;Psychiatric therapeutic procedure;psychoeducation;Psychoses;psychosocial;psychotic symptoms;Quality of life;Randomized, Controlled Trials;readmission rates;Recovery;reduce symptoms;Relapse;remote delivery;Reporting;Research;Research Project Grants;response;Sampling;Schizophrenia;schizophrenia spectrum disorder;service delivery;Service delivery model;service intervention;Services;social media;social stigma;Source;Stigmatization;Stress;stress management;Symptoms;Techniques;Technology;Testing;Text;therapy design;Time;tool;Training;Treatment Efficacy;Underserved Population;United States;United States Substance Abuse and Mental Health Services Administration;usability;user centered design;Work;young adult;Youth

PROJECT_TITLE: User-centered design of a mobile health intervention to promote help-seeking and reduce duration of untreated illness among young adults with early psychosis

STUDY_SECTION: SERV

STUDY_SECTION_NAME: Mental Health Services Study Section[SERV]


FUNDING_MECHANISM: RESEARCH CENTERS

PHR: Narrative: Overall component Understanding the biology of human skin diseases is critical to alleviating suffering and curing these diseases in patients. However, mice and other animals are imperfect models for humans and many therapies developed in mice are not successful in humans. This Center will recruit, empower and support researchers at any institution who wish to work on human cells and tissues by providing access to human tissue biobanks and cutting edge analytic techniques that will allow them to carry out high-quality, human-based research that is directly relevant to human skin disease.

PI_NAMEs: CLARK, RACHAEL ANN (contact)

PROGRAM_OFFICER_NAME: GARCIA-CAZARIN, MARY

PROJECT_TERMS: Acceleration;Address;Advisory Committees;Animal Model;Animals;Antibodies;ATAC-seq;biobank;Biological;Blood;Cells;cellular imaging;Clinical Trials;Color;Communication;Communities;Consent;cost;Cryopreservation;Cytometry;Diagnosis;digital;Disease;DNA Library;Eligibility Determination;empowerment;Environment;Flow Cytometry;Formalin;Frozen Sections;Funding;Gene Expression;Genetic Fingerprintings;Genotype;Goals;Human;Human Biology;human tissue;Image;Immune system;Immunodeficient Mouse;Individual;insight;Institution;International;Knowledge;Leadership;Malignant Neoplasms;Medicine;member;Mentorship;methicillin resistant Staphylococcus aureus;Modeling;mouse model;Mus;nano-string;new technology;next generation;outreach;Paraffin Embedding;Pathologic;Pathology;Patients;people of color;Physicians;Plasma;Population;Positioning Attribute;Protein Analysis;protein expression;Proteins;Protocols documentation;recruit;Research;Research Personnel;Research Project Grants;Resources;RNA;Sampling;Science;Scientist;Serum;Services;Shipping;single cell ATAC-seq;single-cell RNA sequencing;Skin;skin biopsy;skin disorder;Specimen;spectrograph;symposium;System;T cell receptor repertoire sequencing;T-Cell Receptor Genes;Talents;Techniques;Technology;therapy development;Time;Tissue Embedding;Tissues;tool;Training;translational scientist;Underrepresented Populations;Vaccination;Woman;Work

PROJECT_TITLE: Human Skin Disease Resource-based Center


PROJECT_TERMS: Advisory Committees;Communication;Communities;Complex;Electronics;Ensure;experience;Fellowship;flexibility;Funding;General Population;graduate student;Grant;High School Student;Human;Individual;Institution;Instruction;International;Knowledge;Leadership;Medical Students;Medicine;member;Mentors;Mentorship;Mission;next generation;outreach;people of color;Personnel Staffing;podcast;Postdoctoral Fellow;Recruitment Activity;Research;Research Personnel;Research Support;Resources;Science;Services;skin disorder;symposium;Techniques;Training;Translational Research;undergraduate student;Underrepresented Minority;Underrepresented Populations;Vision;visiting scholar;Woman

PROJECT_TITLE: Admin-Core


ADMINISTERING_IC: HL

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Genetics;Neurosciences;Orphan Drug;Rare Diseases;Sleep Research

ORG_CITY: HANOVER

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: PROJECT NARRATIVE  A cell-autonomous molecular clock powers the 24-hour cycles of endogenous regulation of physiology, known as circadian rhythms, which align physiology and behavior to the inherent rotation of the earth. Dysregulation of circadian rhythms has negative physiological effects, such as causing sleep disorders. Our project will increase the understanding of the molecular basis of circadian rhythms, informing the etiology of circadian-based sleep disorders and thereby leading to the development of novel therapies.

PI_NAMEs: STEVENSON, ELIZABETH-LAUREN  (contact)

PROGRAM_OFFICER_NAME: DIXIT, SHILPY

PROJECT_TERMS: Address;Advanced Sleep Phase Syndrome;Animals;arm;ARNTL gene;Behavior;beta-Transducin Repeat-Containing Proteins;Biological;Body Temperature;Cardiovascular system;casein kinase I;Catalytic Domain;Cells;circadian;Circadian Dysregulation;circadian pacemaker;circadian regulation;Circadian Rhythms;Clock protein;Compensation;Core Facility;CSNK2A1 gene;Data;Defect;Development;Disease;Educational process of instructing;Elements;Environment;Etiology;Event;experimental study;Feedback;Fellowship;forward genetics;fungus;Genetic;Genetic Epistasis;Genetic Transcription;Health;Hour;improved;insight;International;kinase inhibitor;Knock-out;Laboratory Finding;Length;Malignant Neoplasms;Mammalian Cell;Mammals;Maps;Mass Spectrum Analysis;Mediating;meetings;Metabolic;Metabolism;mimetics;model organism;Modeling;Molecular;molecular clock;mutant;Mutation;Neurospora;Neurospora crassa;novel;novel therapeutics;Organism;Phenotype;phosphoproteomics;Phosphorylation;Phosphotransferases;Physiological;Physiological Processes;Physiology;Planet Earth;Positioning Attribute;Post-Translational Protein Processing;Process;Property;Proteins;Regulation;Reporter;Research;Role;Rotation;Scientist;Site;Sleep;Sleep Disorders;Sleep Disorders Therapy;Sleep disturbances;sleep regulation;Speed;symposium;System;Techniques;Temperature;Testing;therapy development;Time;Tissues;Training;Translations;ubiquitin ligase;Work

PROJECT_TITLE: Role of Phosphorylation in Determining Circadian Period Length and Temperature Compensation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-Q(20)L]


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hematology;Lymphatic Research;Lymphoma;Prevention;Rare Diseases;Social Determinants of Health;Urologic Diseases

ORG_CITY: RICHMOND

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: Project Narrative In many studies on the risk of disease, investigators analyze the spatial patterns of health outcomes and evaluate residential environmental exposures at the time of study enrollment in hopes of identifying potential causal environmental factors. However, for cancers with long latencies residential locations many years prior to diagnosis are important for determining where and when relevant environmental exposures occurred. In this project we will develop statistical methods that incorporate residential histories to estimate the effect of historic environmental and socio-spatial exposures and identify areas of elevated cancer risk over time.

PI_NAMEs: SABO, ROY TRAVIS (contact)

PROGRAM_OFFICER_NAME: TATALOVICH, ZARIA

PROJECT_TERMS: Accounting;Address;anti-cancer research;Area;Arsenic;Back;Bayesian Modeling;cancer epidemiology;Cancer Model;cancer risk;Chemicals;Data;Databases;Diagnosis;Diet;Disease;disorder risk;Enrollment;environment related cancer;environmental chemical;environmental chemical exposure;Environmental Exposure;Environmental Risk Factor;Epidemiology;epidemiology study;Exposure to;Factor Analysis;Goals;Health;improved;Individual;innovation;interest;Life Cycle Stages;Location;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Measurement;Methodology;Methods;Modeling;Neighborhoods;New England;Non-Hodgkin's Lymphoma;Outcome;Outcomes Research;Pattern;Recording of previous events;Reporting;Research;Research Personnel;residence;Residential Mobility;response;Risk;Risk Estimate;Risk Factors;Sampling;Socioeconomic Status;Statistical Methods;study population;Study Subject;Time;Time Study;time use;Trihalomethanes;United States;United States National Institutes of Health

PROJECT_TITLE: Modeling cancer risk and environmental and socio-spatial exposures using residential histories

STUDY_SECTION: SSPA

STUDY_SECTION_NAME: Social Sciences and Population Studies A Study Section[SSPA]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_CITY: UNIVERSITY PARK

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

ORG_STATE: PA

PHR: Project Narrative: Population Research Institute The Population Research Institute (PRI) at the Pennsylvania State University provides services and activities designed to promote the interdisciplinary study of population dynamics and improve understanding of the conditions needed to support healthy developmental trajectories from early childhood into adulthood. The population science research supported by this award will inform interventions and policies designed to reduce health disparities and improve healthy lifespan development.

PI_NAMEs: VAN HOOK, JENNIFER  (contact)

PROGRAM_OFFICER_NAME: CLARK, REBECCA L

PROJECT_TERMS: Address;Adolescent;Adult;Area;Award;Big Data Methods;Biological Factors;Budgets;career;Child;Child Health;Collaborations;Communication;Communities;Complex;Data;data dissemination;data management;Data Security;design;Development;Dimensions;Disparity;early childhood;Ensure;Environment;Event;Exposure to;Faculty;faculty research;Family;family support;Fostering;Funding;Funding Agency;Generations;Grant;Health;health disparity;health inequalities;Health Status;healthspan;Human;Immigrant;Immigration;improved;Incubators;Individual;Infrastructure;innovation;insight;Institution;Institutional Review Boards;Interdisciplinary Study;Intervention;Investments;Knowledge;Leadership;Learning;Life Cycle Stages;Link;marginalized population;Mechanics;Mediating;Mentors;Methods;migration;Morbidity - disease rate;multiscale data;National Institute of Child Health and Human Development;Neighborhoods;non-traditional data;novel strategies;Pathway Analysis;Pattern;Peer Review;Pennsylvania;Personal Satisfaction;Policies;Population;Population Distributions;Population Dynamics;population health;Population Process;Population Research;Population Sciences;Population Study;Postdoctoral Fellow;prevent;Process;Productivity;programs;Recording of previous events;Reduce health disparities;Regulation;Request for Applications;Research;Research Institute;Research Personnel;Research Project Grants;Research Support;Resources;Scholarship;Scientific Advances and Accomplishments;Scientist;Services;social;Social Change;social determinants;social media;Social Network;Social Processes;success;symposium;Techniques;Technology;Transcend;United States National Institutes of Health;Universities;Work;working group

PROJECT_TITLE: The Population Research Institute


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

PHR: Project Narrative – Administrative Core. Not applicable

PROJECT_TERMS: Address;Advocate;Area;Award;Big Data Methods;Budgets;career;Collaborations;Communication;Communities;Complex;Data;data dissemination;data management;Data Security;design;Development;Dimensions;Ensure;Event;Exposure to;Faculty;faculty research;Family;Fostering;Funding;Funding Agency;Grant;health inequalities;Health Status;Human;Immigrant;Immigration;improved;Incubators;Infrastructure;innovation;insight;Institution;Institutional Review Boards;Interdisciplinary Study;Investments;Leadership;Learning;Link;Mechanics;Mentors;Methods;migration;Mission;multiscale data;National Institute of Child Health and Human Development;Neighborhoods;non-traditional data;novel strategies;operation;Pathway Analysis;Pennsylvania;Personal Satisfaction;Population;Population Dynamics;population health;Population Process;Population Research;Population Sciences;Postdoctoral Fellow;Process;Productivity;programs;Recording of previous events;Regulation;Request for Applications;Research;Research Institute;Research Personnel;Research Project Grants;Research Support;Resources;Scientific Advances and Accomplishments;Scientist;Services;social media;Social Network;success;symposium;Techniques;Technology;Transcend;United States National Institutes of Health;Universities;Work;working group

PROJECT_TITLE: The Population Research Institute: Administrative Core


NIH_SPENDING_CATS: Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Pediatric

ORG_CITY: JOHNSON

ORG_DEPT: PSYCHOLOGY

ORG_NAME: NORTHERN VERMONT UNIVERSITY-JOHNSON

ORG_STATE: VT

PHR: PUBLIC HEALTH RELEVANCE Young infants show remarkably different reactions to expectancy violations, but it is not clear why. This research will examine how infants distinguish between different types of events, contributing fundamental knowledge about early cognitive and social capacities with implications for enhancing human development.

PI_NAMEs: MIREAULT, GINA  (contact)

PROGRAM_OFFICER_NAME: BASKIR, RUBIN SAM

PROJECT_TITLE: Infants' Understanding of Violations of Expectation: The Role of Social Agents and Repetition


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

ORG_CITY: LOUISVILLE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF LOUISVILLE

ORG_STATE: KY

PHR: The goal of the University of Louisville Center for Integrative Environmental Health Sciences is to understand how exposure to environmental toxicants interacts with life style factors and how these co-exposures impact human health and disease, as modified by life stage and gender. This knowledge will provide better prevention and intervention strategies to improve the health of the people in western Kentucky.

PI_NAMEs: STATES, J CHRISTOPHER (contact)

PROGRAM_OFFICER_NAME: THOMPSON, CLAUDIA L

PROJECT_TERMS: addiction;Adult;Agriculture;Alcohol consumption;Alcohols;Area;Basic Science;Biological Models;Biometry;built environment;Cardiovascular system;career development;Chemicals;Childhood;Chronic;Chronic Disease;citizen science;Clinical;Clinical Trials;Clinical Trials Unit;Collaborations;Communication;Communities;community based participatory research;community based research;community collaboration;community engagement;community partners;Complex;Core Facility;County;design;Development;Diabetes Mellitus;Diet;Disease;Disease Outcome;Ecosystem;Education;Environment;Environmental Health;Environmental Risk Factor;Etiology;Exposure to;Funding;Gender;Genetic;Genetic Predisposition to Disease;Genotype;Geographic Locations;Goals;Grant;Health;Health Personnel;health science research;Health Sciences;Human;improved;Individual;Industrialization;Informatics;Interdisciplinary Study;Interest Group;Intervention;Investigation;Kentucky;Knowledge;Laboratories;Leadership;Life;Life Style;lifestyle factors;Malignant Neoplasms;man;Measurement;member;Mental disorders;Mentors;Mentorship;Metals;metropolitan;Modification;multidisciplinary;next generation;Obesity;Organ;Pathogenesis;Persons;Pilot Projects;Play;pollutant;Pollution;Polychlorinated Biphenyls;Positioning Attribute;Predisposition;Prevention strategy;Program Development;programs;recruit;Research;Research Personnel;Resources;response;Role;Rural;rural environment;rural healthcare;skills;socioeconomics;Strategic vision;stressor;tobacco exposure;tobacco products;Toxic Environmental Substances;Toxicant exposure;toxicant interaction;Toxicology;Training;Translating;Translations;United States;Universities;urban setting;Vinyl Chloride;Youth

STUDY_SECTION: EHS

STUDY_SECTION_NAME: Environmental Health Sciences Review Committee[EHS(P)]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Clinical Research;Infectious Diseases;Urologic Diseases

ORG_CITY: HOUSTON

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: Urinary tract infections (UTIs) are one of the most common infections diagnosed each year and a driving force behind the increasing bacterial resistance to antibiotics. This project will investigate how bacteriophages, viruses that infect bacteria, can be used as new treatments for UTIs. The project will also define the safety of using bacteriophages to treat UTIs and describe how bacteria try to avoid being killed by bacteriophages.

PI_NAMEs: ZULK, JACOB JEFFREY (contact)

PROGRAM_OFFICER_NAME: MARIC-BILKAN, CHRISTINE

PROJECT_TERMS: Affect;Animal Model;anti-microbial peptide;Antibacterial Response;Antibiotic Resistance;Antibiotic Therapy;Antibiotics;antimicrobial;Antimicrobial Resistance;Attenuated;Automobile Driving;Bacteria;Bacterial Antibiotic Resistance;bacterial fitness;Bacterial Infections;Bacteriology;Bacteriophages;Binding;Bladder;career;career development;Cells;Clinic;Clinical;Collection;college;Communities;cost;cytokine;Data;Defect;Development;Diabetes Mellitus;Diagnosis;disease model;driving force;Environment;environmental stressor;Enzyme-Linked Immunosorbent Assay;Epithelium;Escherichia coli;experience;extracellular;Fellowship;fitness;Flow Cytometry;Goals;Growth;Health Care Costs;host microbiome;Human;human imaging;Immune;Immune response;Impairment;In Vitro;in vivo;in vivo Model;Infection;infectious disease treatment;innovation;Intracellular Space;Knowledge;Label;Lipopolysaccharides;live cell imaging;Mammalian Cell;Medical;Medicine;Membrane;Membrane Proteins;Mentorship;Methods;Microscopy;Modeling;mouse model;Mus;mutant;Mutation;novel;Nutrient;Nutrient availability;older adult;Organoids;pathogen;Pathogenesis;pathogenic bacteria;Patients;Phage Receptors;Predisposition;Proteins;Public Health;Publishing;receptor;Recurrence;recurrent infection;Research;Research Personnel;Resistance;Route;Safety;skills;standard of care;superresolution microscopy;Techniques;Testing;Therapeutic;tool;Training;Translating;United States;uptake;urinary;Urinary tract;Urinary tract infection;Urine;Uropathogenic E. coli;Virus;Western Blotting;Woman;Work

PROJECT_TITLE: Investigating phage therapy for the treatment of urinary tract infections


NIH_SPENDING_CATS: Clinical Research;Social Determinants of Health

PHR: Project Narrative – Development Core. Not applicable

PI_NAMEs: DAMASKE, SARAH  (contact)

PROJECT_TERMS: Area;Award;Big Data;career;Collaborations;Communities;Consultations;design;Development;Educational workshop;Event;Exposure to;Eye;Faculty;Family;Financial Support;flexibility;Fostering;Funding;Goals;Grant;Growth;Human;Immigrant;Immigration;Incubators;innovation;Institution;interest;Investments;Learning;lectures;meetings;member;Mentors;Mentorship;Methodology;Methods;mid-career faculty;migration;National Institute of Child Health and Human Development;Neighborhoods;novel;Pennsylvania;Personal Satisfaction;Persons;Population;Population Dynamics;population health;Population Process;Population Research;Population Sciences;Process;Productivity;programs;recruit;Research;Research Institute;Research Personnel;Research Project Grants;Resource Sharing;Resources;Scientific Advances and Accomplishments;Scientist;Series;Services;Social Network;success;Twin Multiple Birth;Universities;virtual;Visit;working group

PROJECT_TITLE: The Population Research Institute: Development Core


ED_INST_TYPE: OTHER SPECIALIZED SCHOOLS

NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: Princeton

ORG_DEPT: MISCELLANEOUS

ORG_NAME: PRINCETON UNIVERSITY

ORG_STATE: NJ

PHR: PROJECT NARRATIVE  The highly conserved extracellular signal-regulated kinase (Erk) pathway regulates tissue growth and patterning throughout development, and mutations in Erk pathway components are common causes of cancer. Understanding how cells interpret complex and dynamic Erk signals to yield distinct cell fates will significantly inform our understanding of how this pathway contributes to disease, yet these mechanisms have been difficult to identify. I propose to use innovative optogenetic tools in the Drosophila embryo, a classic and well-defined in vivo model for Erk signal interpretation, to define the molecular mechanisms by which this important pathway measures and interprets Erk signal dose to effect gene expression.

PI_NAMEs: HO, EMILY KOLENBRANDER (contact)

PROGRAM_OFFICER_NAME: STAMM, JOYCE CHIN-CHIN NG

PROJECT_TERMS: Address;Affect;Anterior;Biosensor;Cancer Etiology;career;Cells;Cellular biology;Complex;Decision Making;Development;Developmental Biology;Diffusion;Disease;Dissection;Dose;Drosophila genus;Drosophila melanogaster;Ectoderm;Embryo;Embryonic Development;Endoderm;Event;Extracellular Signal Regulated Kinases;gastrulation;Gene Expression;Gene Expression Profile;Genes;Genetic;genetic manipulation;Genetic Transcription;Genomic approach;Genomics;Goals;Growth;Head;Human Development;imaging approach;in vivo;in vivo Model;innovation;Laboratories;Light;Malignant Neoplasms;Measures;Mediating;Microscopy;Midgut;Molecular;Mutation;optogenetics;Output;Pathway interactions;Pattern;Physiologic pulse;Play;Positioning Attribute;programs;Proteins;Reporter;Research;response;Role;Signal Pathway;Signal Transduction;Spatial Distribution;Specific qualifier value;Structure;Tail;Time;Tissue Model;Tissues;tool;Training;transcription factor;transcriptome sequencing;Travel;tumor progression;Work;wound healing

PROJECT_TITLE: Optogenetic dissection of Erk signal interpretation in early embryogenesis


NIH_SPENDING_CATS: Clinical Research

PI_NAMEs: ASTER, JON C. (contact)

PROJECT_TERMS: Acceleration;Address;Adult;Animal Model;Back;biobank;Blood;Callback;Cells;Clinical;cohort;Collaborations;Communities;Consent;Diagnosis;disease diagnosis;DNA;Drug Delivery Systems;Engraftment;Formalin;Generations;Genotype;Geographic Locations;Goals;graft vs host disease;Human;human tissue;immunodeficiency;Immunodeficient Mouse;Inflammation;Institution;Institutional Review Boards;Medical Records;Mus;Neonatal;Paraffin Embedding;Pathologic;Patients;penis foreskin;Plasma;Population;Protocols documentation;Research;Research Personnel;Resources;Sampling;Serum;service utilization;Services;Signal Transduction;Skin;skin disorder;skin fibrosis;Specimen;T-Lymphocyte;tissue resident memory T cell;Tissues;trafficking

PROJECT_TITLE: Human Tissues Biobank Core


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Kidney Disease;Lupus;Organ Transplantation;Social Determinants of Health;Transplantation

ORG_CITY: ATLANTA

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Kidney transplantation is one of two treatment options for patients with lupus nephritis-associated end-stage kidney disease (LN-ESKD), although there is little information regarding access to early steps in the kidney transplant process for this patient population. The proposed research project will use a multilevel approach to evaluate access to referral for an evaluation at a kidney transplant center (the first step in the kidney transplant process) in patients with LN-ESKD by examining socioeconomic and health system factors that may be impacting referral access. The results of this project could be used to inform interventions that focus on timely referral for kidney transplant and ultimately improve long-term outcomes among LN-ESKD patients.

PI_NAMEs: MCPHERSON, LAURA  (contact)

PROJECT_TERMS: Adult;Affect;Age;Allografting;Autoimmune Diseases;care coordination;career;Cessation of life;Characteristics;Chronic;chronic autoimmune disease;Chronic Disease;Classification;clinical practice;Communication;community partners;Complex;Cox Proportional Hazards Models;Data;Data Reporting;Databases;Development;Diagnosis;Dialysis procedure;Eligibility Determination;End stage renal failure;Ensure;Epidemiology;Ethnic Origin;Evaluation;Female;Gender;Geographic Locations;Goals;health inequalities;Health Services Research;Health system;Healthcare Systems;Hemodialysis;high risk;Improve Access;improved;improved outcome;Individual;Inflammation;Information Systems;insight;Intervention;Kidney;Kidney Failure;Kidney Transplantation;Knowledge;Life;Link;Literature;Logistics;low socioeconomic status;Lupus;Lupus Nephritis;Maintenance;Mediating;Medical;Mentors;minority patient;multilevel analysis;national surveillance;Neighborhoods;novel;Organ;Outcome;Patient Care;patient population;Patients;Persons;Population;post-transplant;Poverty;premature;Prevalence;primary care provider;Process;Provider;Race;racial minority;Registries;Reporting;Research;Research Personnel;Research Project Grants;Research Proposals;residence;Residual state;Retrospective cohort;skills;socioeconomics;Specialist;surveillance data;System;Systemic Lupus Erythematosus;Time;transplant centers;Transplantation;United States;Visit;Waiting Lists

PROJECT_TITLE: Early Access to Kidney Transplantation among Patients with Lupus Nephritis


NIH_SPENDING_CATS: Bioengineering;Emerging Infectious Diseases;Infectious Diseases;Networking and Information Technology R&D (NITRD);Social Determinants of Health

ORG_CITY: FLAGSTAFF

ORG_NAME: NORTHERN ARIZONA UNIVERSITY

ORG_STATE: AZ

PHR: Project Narrative The COVID-19 pandemic demonstrated the potential of epidemiological modeling for planning public health responses, but also exposed significant practical obstacles to its real-world application in local-level decision- making. Here we face this challenge head on, developing a next-generation informatics portal called EpiMoRPH that standardizes and automates the model evaluation process, facilitating collaborations between modelers and public health stakeholders to determine the best modeling approaches to address local needs. Moreover, we will develop an Optimization Engine, which will provide a substantially automated toolkit for local public health stakeholders to build disease control strategies that balance minimizing disease outcomes and maximizing equitable distribution of interventions across racial, ethnic, and socioeconomic sectors.

PI_NAMEs: MIHALJEVIC, JOSEPH  (contact)

PROGRAM_OFFICER_NAME: GEZMU, MISRAK

PROJECT_TERMS: 2019-nCoV;Address;Adopted;Algorithms;authority;Automation;Automobile Driving;Benchmarking;Case Study;Case/Control Studies;Cities;Collaborations;Communicable Diseases;Communication;Communities;Community Health;Complement;Consensus;County;COVID-19;COVID-19 pandemic;crowdsourcing;cyber infrastructure;Data;Data Set;Decision Making;Decision Support Systems;design;disease model;Disease Outcome;disorder control;Elements;Emerging Communicable Diseases;Ensure;Environment;Epidemic;epidemiological model;Epidemiology;Equilibrium;Equity;Ethnic Origin;Evaluation;experience;Face;Goals;Head;Health Planning;infectious disease model;Informatics;informatics infrastructure;informatics tool;innovation;Insecticides;interactive tool;Intervention;intervention refinement;Life;mathematical model;meetings;Methodology;Methods;model development;Modeling;Motivation;Municipalities;next generation;pandemic disease;participant interview;pathogen;Performance;Positioning Attribute;Procedures;Process;prototype;Public Health;Public Health Practice;Race;real world application;Refit;Research;Research Personnel;Resources;response;simulation environment;socioeconomics;spatial epidemiology;Specific qualifier value;St. Louis Encephalitis Virus;Standardization;Structure;Study models;System;technological innovation;Technology;Testing;theories;Time;tool;Training;transmission process;Uncertainty;US State;usability;Vaccination;Validation

PROJECT_TITLE: EpiMoRPH: A simulation environment for generating spatially-refined intervention strategies for the control of infectious disease

STUDY_SECTION: BMRD

STUDY_SECTION_NAME: Biostatistical Methods and Research Design Study Section[BMRD]


ORG_CITY: NOTRE DAME

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF NOTRE DAME

ORG_STATE: IN

PHR: PROJECT NARRATIVE As the most commonly diagnosed noncutaneous malignancy and the second leading cause of cancer mortality for American men, prostate cancer remains an important public health concern. Advanced prostate cancer is resistant to therapeutics blocking immune checkpoint molecules such as PD1 or CTLA4 with the cold tumor microenvironment as a major contributing factor. Upon completion of our project, we will define the functional role and mechanisms of the chromatin regulatory protein PYGO2 (frequently amplified in advanced prostate cancer) as the key signaling hub to foster the cold prostate tumor microenvironment, and identify PYGO2 inhibitors with the potential to turn the microenvironment from cold to hot and enhance the response of prostate cancer to immunotherapy.

PI_NAMEs: LU, XIN  (contact)

PROGRAM_OFFICER_NAME: VENKATACHALAM, SUNDARESAN

PROJECT_TERMS: 1q21;Ablation;Acceleration;advanced prostate cancer;American;anti-CTLA4;anti-PD1 antibodies;Antibodies;antitumor effect;Attenuated;bench-to-bedside translation;beta catenin;Binding;cancer cell;Cancer Etiology;Cancer Patient;cancer therapy;cancer type;Cell Proliferation;Cells;Chromatin;Clinical;Combination immunotherapy;Correlation Studies;CTLA4 gene;curative treatments;cytokine;cytotoxic CD8 T cells;Cytotoxic T-Lymphocytes;Data;Development;Diagnosis;Enzymes;Epigenetic Process;Family;Fostering;Gene Amplification;Gene Expression Regulation;Genetic;Genetic Models;genetic regulatory protein;Genetic Transcription;Goals;Histone H3;Immune;immune checkpoint;immune checkpoint blockade;Immune Evasion;Immunologics;Immunosuppression;Immunotherapy;improved;Infiltration;inhibitor;Knock-out;Lymphocytic Infiltrate;Lysine;Malignant neoplasm of prostate;Malignant Neoplasms;Mediating;men;Metastatic Prostate Cancer;Methylation;Molecular;mortality;mouse model;Mus;Mutation;Myeloid-derived suppressor cells;Neoplasm Metastasis;new therapeutic target;novel;Oncogenic;Outcome;Pathway interactions;Patients;pharmacologic;PHD Finger;Play;Population;pre-clinical;programmed cell death protein 1;programs;prostate cancer cell;prostate cancer model;prostate cancer progression;Prostate Cancer therapy;Prostatic Neoplasms;Public Health;Refractory;research clinical testing;Resistance;response;Role;Shapes;Signal Transduction;small molecule inhibitor;Study models;Tail;Testing;Therapeutic;therapeutically effective;Tryptophan 2,3 Dioxygenase;tumor;Tumor Burden;Tumor Escape;tumor microenvironment;tumor-immune system interactions;Up-Regulation

PROJECT_TITLE: Converting Cold to Hot Tumor Microenvironment in Prostate Cancer by Targeting Chromatin Effector

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-M(08)F]


NIH_SPENDING_CATS: Cardiovascular;Childhood Obesity;Clinical Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Nutrition;Obesity;Pediatric;Physical Activity;Prevention

ORG_CITY: COLUMBIA

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

ORG_STATE: SC

PHR: PROJECT NARRATIVE Accurate assessment of children’s (5-12yrs) free-living physical activity energy expenditure (PAEE) is fundamental to understanding the complex and interdependent relationship between children’s PAEE and health outcomes, such as diabetes and obesity. The inclusion of activity type in regression equations that use movement and heart rate may allow for more accurate assessment of children’s free-living PAEE beyond that of combining movement and heart rate. The unique ability of consumer wearables to autodetect activity type and assess heart rate and movement metrics could advance the assessment of children’s free-living PAEE.

PI_NAMEs: WHITE III, JAMES W. (contact)

PROGRAM_OFFICER_NAME: RIVERS, ROBERT C

PROJECT_TITLE: Utility and feasibility of activity type to augment consumer wearable-based physical activity energy expenditure prediction equations using heartrate and movement in children


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Digestive Diseases;Obesity

ORG_CITY: ANN ARBOR

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE This T32 grant, “Obesity & Gastrointestinal Surgery Scientist Training Program” integrates all aspects of obesity and gastrointestinal surgery research at the University of Michigan – from “bench to bedside, and practice to policy”— allowing us to address fundamental questions about obesity and gastrointestinal surgery in a multidisciplinary way. As outlined in our proposal, we believe the University of Michigan is in a unique position to conduct this training program due to a critical mass of scientists focused on both basic science and health services research.

PI_NAMEs: DIMICK, JUSTIN BRIGHAM (contact);SEELEY, RANDY J

PROGRAM_OFFICER_NAME: KAMARA, FANTA

PROJECT_TERMS: bariatric surgery;Gastrointestinal Surgical Procedures;Research Training;Training Programs

PROJECT_TITLE: Obesity & Gastrointestinal Surgery Research Training Program


ED_INST_TYPE: GRADUATE SCHOOLS

ORG_DEPT: ENGINEERING (ALL TYPES)

PHR: NARRATIVE Radiation therapy with high dose rates is undergoing a revolution because of the recent realization the scope of normal tissue damage is modulated by the dose rate. This research program will establish the dosimetry tools and mechanisms needed to understand, control and plan this type of FLASH radiation therapy treatment, which spares normal tissues more than tumor tissue.

PI_NAMEs: GLADSTONE, DAVID J.;HOOPES, JACK ;POGUE, BRIAN WILLIAM (contact)

PROGRAM_OFFICER_NAME: OBCEMEA, CEFERINO H

PROJECT_TERMS: Address;Adoption;Agreement;Animals;Area;Basic Science;Beds;Biochemistry;Biological Assay;Biology;Biomedical Engineering;Brain;Breast;Canis familiaris;cell killing;Chemistry;Clinical;Colon;Consumption;Data;design;Devices;DNA Damage;Doctor of Philosophy;Dose;Dose Rate;dosimetry;Effectiveness;Electron Spin Resonance Spectroscopy;Engineering;Ensure;first-in-human;Free Association;Free Radicals;Future;gastrointestinal;Genetic;Head and neck structure;Human;Hypoxia;Image;improved;In Situ;In Vitro;in vivo;Institution;instrumentation;internal radiation;International;invention;Iowa;Iron;irradiation;Link;luminescence;Lung;Lymphoma;Malignant Neoplasms;Measurement;Measures;Methods;Molecular;Morphology;mouse model;Normal tissue morphology;Norris Cotton Cancer Center;open source;Optics;oxidation;Oxygen;Oxygen saturation measurement;Pathology;Pathway interactions;Patients;Performance;phenomenological models;Physics;Physiologic pulse;pre-clinical;preservation;Production;programs;Proteomics;prototype;Publications;Radiation;Radiation Dose Unit;radiation effect;Radiation Genetics;Radiation induced damage;Radiation Oncology;Radiation Physics;Radiation therapy;Radiobiology;Radiochemistry;Reaction;Reactive Oxygen Species;repaired;Research;Research Project Grants;Risk;Running;Schools;Skin;System;Techniques;Technology;Therapeutic;Therapeutic Effect;Therapeutic Equivalency;tissue oxygenation;Tissue Preservation;Tissues;tool;Translations;treatment comparison;treatment planning;tumor;Tumor Tissue;United States National Institutes of Health;Validation;Work

PROJECT_TITLE: Optimization of MeV FLASH radiotherapy for normal tissue preservation

STUDY_SECTION: ITD

STUDY_SECTION_NAME: Imaging Technology Development Study Section[ITD]


PI_NAMEs: LEDERER, JAMES A. (contact)

PROJECT_TERMS: Acceleration;advanced analytics;Antibodies;antibody conjugate;Biological Models;Biology;Biometry;Cells;cellular imaging;Clinical Trials;Clone Cells;cost;Cryopreservation;Custom;Cytometry;Data Analyses;Distant;DNA;Experimental Designs;Flow Cytometry;Geographic Locations;Human;Human Biology;Image;image reconstruction;Immune;Immune response;Immunobiology;Inflammatory;insight;Institution;Location;mouse model;next generation;Pathogenicity;Patients;Preparation;Proteins;Protocols documentation;Rare Earth Metals;Reagent;Research;Research Design;Research Personnel;Research Project Grants;Resources;Sampling;Sampling Studies;service utilization;Services;Shipping;single cell ATAC-seq;single-cell RNA sequencing;Skin;skin biopsy;skin disorder;Stains;T cell receptor repertoire sequencing;T-Cell Receptor Genes;T-Lymphocyte;Techniques;Time;Tissues;Transgenic Mice;Transgenic Model

PROJECT_TITLE: Single Cell and Immunoanalysis Core


NIH_SPENDING_CATS: Data Science;Networking and Information Technology R&D (NITRD)

PHR: Project Narrative – CSA Core. Not applicable

PI_NAMEs: CHI, GUANGQING  (contact)

PROJECT_TERMS: Acceleration;Area;Big Data;Cloud Computing;Collaborations;Collection;Complex;complex data;computing resources;Contracts;cost effective;Data;data access;Data Analyses;Data Collection;data enclave;data infrastructure;data integration;data management;data repository;Data Set;Data Sources;Databases;Demographer;Development;Dimensions;Educational process of instructing;Educational workshop;Ensure;Environment;Funding;Grant;health data;High Performance Computing;improved;Individual;Infrastructure;Infusion Technique;innovation;Machine Learning;Mediation;Mentors;Methodology;Methods;multiscale data;National Archive;non-traditional data;Pathway Analysis;Performance;Population;Population Dynamics;Population Research;Population Sciences;Productivity;Provider;Regulation;Research;Research Institute;Research Personnel;Research Project Grants;Research Support;Resources;Role;Scientist;Secure;Services;social media;Social Network;Social Problems;Source;spatiotemporal;statistics;success;System;Techniques;tool;Twitter;Universities;web site

PROJECT_TITLE: The Population Research Institute: Computational and Spatial Analysis


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Genetics;Neurosciences

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE In neurons, the scaffolding protein gephyrin plays a critical role in altering GABAergic synaptic inhibition during plasticity. The goal of this project is to study gephyrin synthesis during inhibitory synaptic plasticity to understand neuronal mechanisms underlying precise and lasting changes in inhibitory synaptic strength. This will provide crucial insight into how inhibitory synaptic plasticity supports the balance of excitation and inhibition, the disruption of which is implicated in pathologies such as epilepsy, schizophrenia, and autism spectrum disorders.

PI_NAMEs: WELLE, THERESA MARIE (contact)

PROGRAM_OFFICER_NAME: CHURN, SEVERN BORDEN

PROJECT_TERMS: Affect;autism spectrum disorder;Automobile Driving;Biological Assay;Chemosensitization;Cognition;confocal imaging;Data;Dendrites;Electrophysiology (science);Epilepsy;Equilibrium;Excitatory Synapse;experimental study;Functional disorder;Genes;gephyrin;Glutamates;Goals;Image;immunocytochemistry;In Situ;Inhibitory Synapse;insight;Knowledge;Label;Learning;Ligation;Long-Term Depression;Long-Term Potentiation;Maintenance;Measures;Mediating;Memory;Messenger RNA;MicroRNAs;Molecular;mRNA Translation;N-Methyl-D-Aspartate Receptors;neural;neural circuit;neuronal cell body;neuronal excitability;Neurons;Neurophysiology - biologic function;overexpression;Pathology;Play;postsynaptic;Protein Biosynthesis;Proteins;Proteome;Puromycin;receptor;Regulation;Research;Role;scaffold;Scaffolding Protein;Schizophrenia;Shapes;single molecule;Site;Synapses;synaptic function;synaptic inhibition;Synaptic plasticity;Synaptic Transmission;Testing;Transcript;Translating;translational impact;Translational Regulation;Translations;Untranslated RNA;Visualization

PROJECT_TITLE: The role of gephyrin translation in inhibitory synaptic plasticity


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Frontotemporal Dementia (FTD);Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Parkinson's Disease;Rare Diseases

ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: NARRATIVE In this proposal, we will be developing, disseminating, and evaluating a web-based software tool that can perform MRI analyses for the diagnostic accuracy of Parkinsonism. Our goal is to leverage our years of experience and algorithm development, to test a prospective cohort of Parkinson’s disease, Multiple System Atrophy, and Progressive Supranuclear Palsy. We expect that at the end of the project, we will have validated a web-based software tool that can use MRIs from different vendors to read, analyze, and predict the diagnosis of different forms of Parkinsonism.

PI_NAMEs: BARMPOUTIS, ANGELOS ;OKUN, MICHAEL S;VAILLANCOURT, DAVID E (contact)

PROGRAM_OFFICER_NAME: TAYLOR-BURDS, CAROL C

PROJECT_TERMS: accurate diagnosis;algorithm development;Algorithms;American;Area Under Curve;atypical parkinsonism;Autopsy;Biological Markers;Blinded;Brain;Clinic;clinic ready;Clinical;clinical diagnosis;clinical trial readiness;Clinical Trials;cohort;Communities;Data;Data Collection;data exchange;Dementia;dementia risk;Diagnosis;Diagnostic;diagnostic accuracy;diagnostic algorithm;diagnostic biomarker;diagnostic criteria;Differential Diagnosis;Diffusion;Diffusion Magnetic Resonance Imaging;Disease;disease diagnosis;dopamine transporter;Enrollment;experience;Goals;Growth;Health;Image;imaging biomarker;improved;indexing;individualized medicine;innovation;Machine Learning;Magnetic Resonance Imaging;Modeling;Motor;Movement Disorders;Multiple System Atrophy;Nerve Degeneration;Neurologic;Neurologist;Online Systems;Outcome;Paper;Parkinson Disease;Parkinsonian Disorders;Participant;Pathologic;Pathology;Patient Care;Patients;performance tests;Persons;Pharmaceutical Preparations;Phase;Phase III Clinical Trials;Probability;Procedures;Process;Prognosis;programs;Progressive Supranuclear Palsy;Prospective cohort;Protocols documentation;Qualifying;quality assurance;Radiology Specialty;Reading;Research Personnel;Secure;Signal Transduction;Site;Software Tools;Structure;support vector machine;System;Techniques;Testing;timeline;Tissues;tool;Training;Translating;treatment planning;Validation;Variant;Vendor;Water;web based software;web site

PROJECT_TITLE: Web-based Automated Imaging Differentiation of Parkinsonism

STUDY_SECTION: NSD

STUDY_SECTION_NAME: Neurological Sciences and Disorders B Study Section[NSD-B]


PROJECT_TERMS: Advisory Committees;Applications Grants;Area;Award;Biometry;candidate identification;career;career development;cofactor;Collaborations;Communication;Communities;community engagement;Core Facility;Data;design;Disease;disorder risk;Effectiveness;Electronic Mail;Ensure;Environmental Health;Evaluation;Exposure to;Faculty;Focus Groups;Fostering;Gender;Genetic;Goals;Grant;Health;Health Personnel;health science research;Health Sciences;Human;improved;Individual;Informatics;Interdisciplinary Study;interest;Interest Group;Lead;Leadership;Life;Life Style;lifestyle factors;Measurement;Measures;Mediating;meetings;member;Mentors;Mentorship;Methods;Monitor;National Institute of Environmental Health Sciences;Outcome;Output;patient population;Pilot Projects;pollutant interaction;Pollution;Prevention;Process;Productivity;Program Development;programs;Publications;recruit;Recruitment Activity;Reporting;repository;Research;Research Personnel;Resources;Schedule;Scientist;Societies;success;symposium;Telephone;Toxic Environmental Substances;Toxicology;Translational Research;Translations;Universities;Vision;Youth

PROJECT_TITLE: ADMINISTRATIVE CORE

STUDY_SECTION_NAME: Environmental Health Sciences Review Committee[EHS]


NIH_SPENDING_CATS: Genetics

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PI_NAMEs: MIHM, MARTIN C. (contact)

PROJECT_TERMS: Acceleration;Antibodies;Antigens;Biopsy Specimen;cell type;Cells;clinical care;Clinical Trials;Color;Communities;Computer software;Dermatology;digital;digital technology;DNA;Expression Profiling;Formalin;Freezing;Frozen Sections;Gene Expression;Genetic Fingerprintings;Human;Image;imaging study;imaging system;Immunofluorescence Immunologic;Individual;Institution;Label;Measurement;Messenger RNA;MicroRNAs;nano-string;next generation;Paraffin Embedding;Patients;protein profiling;Proteins;Protocols documentation;Research;Research Personnel;research study;Resources;Retrieval;RNA;Sampling;service utilization;Skin;skin biopsy;skin disorder;Specimen;spectrograph;Stains;Techniques;Technology;Tissues;UV sensitive;Work

PROJECT_TITLE: Next Generation Tissue Analysis and Imaging Core


NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Rural Health;Social Determinants of Health

PI_NAMEs: HUNTINGTON-MOSKOS, LUZ G (contact)

PROJECT_TERMS: Address;Agriculture;Area;Area Health Education Centers;Awareness;burden of illness;catalyst;Chronic Disease;Collaborations;Communication;Communities;community academic partnership;community engaged research;community engagement;community involvement;community organizations;community partners;Core Facility;Decision Making;Diabetes Mellitus;Disease;Ensure;Environmental Exposure;Environmental Hazards;Environmental Health;experience;Exposure to;Family;Gender;Goals;Health;health assessment;health knowledge;health literacy;Health Personnel;Health Resources;health science research;Health Sciences;Healthcare Systems;household environmental exposure;Housing;Human;Huntington Disease;Hypertension;Industry;Kentucky;Knowledge;Leadership;Life;lifestyle factors;literacy;Malignant Neoplasms;manufacture;member;National Institute of Environmental Health Sciences;Newspapers;Obesity;outreach;Pilot Projects;Pollution;programs;Public Health;Research;research faculty;Research Personnel;Resources;Role;Rural;rural area;social media;Structure;superfund site;Toxic Environmental Substances;Translating;Translational Research;Translations;Universities;urban area;Vision;Work;Youth

PROJECT_TITLE: COMMUNITY ENGAGEMENT


NIH_SPENDING_CATS: Biotechnology;Genetics;Lung;Pulmonary Fibrosis;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: Project Narrative: The proposed research is fundamental to our understanding of the molecular pathophysiology of alveolar type II (AT2) progenitor stem cells in interstitial lung diseases, which have a significant relevance to public health. These studies will inform the development of new therapies to improve AT2 cell function and cell survival, ultimately protecting patients from lung fibrosis.

PI_NAMEs: RODRIGUEZ, ANTONY  (contact)

PROGRAM_OFFICER_NAME: GOMEZ, CHRISTIAN RENE

PROJECT_TERMS: age related;Aging;Alveolar;alveolar lamellar body;Alveolitis;Alveolus;Animal Model;Apoptosis;Appearance;Architecture;AT-Hook Motifs;ATAC-seq;Autophagocytosis;Bioenergetics;Biological Assay;Bleomycin;Cell Aging;Cell Compartmentation;Cell Differentiation process;cell growth;Cell Physiology;Cell Survival;Cells;Cellular Metabolic Process;Characteristics;Chronic lung disease;Collagen;Complex;Data;Defect;Deposition;Development;disease diagnosis;DNA;drug discovery;effective therapy;Enhancers;Ensure;epithelial stem cell;Experimental Genetics;Family;Felis catus;Fibrosis;Functional disorder;Generations;Genes;Genetic;Genus Hippocampus;Goals;healing;Homeostasis;Human;human tissue;Hyperplasia;Hypoxemia;idiopathic pulmonary fibrosis;Immune;Immunofluorescence Immunologic;Impairment;improved;in vivo;Inflammation;Injury;insight;Interstitial Lung Diseases;Knockout Mice;Knowledge;lipid metabolism;Lipids;Lung;Lung fibrogenesis;lung injury;Measurement;Metabolic;MicroRNAs;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;Natural regeneration;Nodal;novel therapeutics;Organelles;Pathogenicity;Pathway interactions;Patients;Physiological;Play;Pluripotent Stem Cells;Polycomb;prevent;Process;progenitor;programs;Proliferating;Proteins;Proto-Oncogene Proteins c-myc;Public Health;Pulmonary Emphysema;Pulmonary Fibrosis;Pulmonary Surfactants;Quality Control;Regulation;repaired;Repression;Research;Resolution;response;Role;senescence;single-cell RNA sequencing;Somatic Cell;stem;stem cell division;stem cell fate;stem cell population;stem cells;Stress;surfactant;surfactant production;System;Testing;Time;Tissue Model;tissue repair;Tomatoes;Tracer;transcription factor;transcriptomics;transdifferentiation;Transitional Cell;Upstream Enhancer;Work

PROJECT_TITLE: Delineating the role of let-7 microRNA on lung AT2 cell homeostasis, alveolar regeneration, and interstitial lung disease

STUDY_SECTION: LIRR

STUDY_SECTION_NAME: Lung Injury, Repair, and Remodeling Study Section[LIRR]


PI_NAMEs: CAVE, MATTHEW C (contact)

PROJECT_TERMS: Adult;Affect;Basic Science;biobank;Biological;Biological Markers;Biometry;Charge;Charities;Childhood;Chronic Disease;Clinical;clinical practice;Clinical Research;Clinical Trials;Clinical Trials Unit;cohort;Communities;community engagement;community involvement;community organizations;Consent;Consultations;Core Facility;cost effective;Data;Data Analyses;design;Development;Disease;Doctor of Medicine;Early Diagnosis;Ensure;Environment;Environmental Health;Evaluation;experience;Fee-for-Service Plans;follow-up;Goals;Health;Health Sciences;Health Services Accessibility;Human;human data;Human Resources;human subject;Human Subject Research;improved;Informatics;Infrastructure;innovation;instrument;instrumentation;Interdisciplinary Study;interest;Interest Group;Intervention;Knowledge;Life;lifestyle factors;Measurement;Measures;member;metabolomics;Metagenomics;Metals;multidisciplinary;National Institute of Environmental Health Sciences;Nature;patient oriented;Performance;Pharmaceutical Preparations;Physicians;Pilot Projects;Pollution;Population Research;Prevention;Program Evaluation;programs;Proteomics;Public Health Practice;Randomized;recruit;Reporting;Research;Research Design;Research Personnel;Research Support;response;Retrieval;sample collection;Sampling;Scientist;Services;sex;Technology;Therapeutic Intervention;Time;Training and Education;transcriptomics;Translating;Translational Research;Universities;volatile organic compound

PROJECT_TITLE: Integrated Health Science Facility Core


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: MAYWOOD

ORG_NAME: LOYOLA UNIVERSITY CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Cardiometabolic disease (CMD), often a precursor to cardiovascular disease, is associated with a two-fold risk of mortality from coronary artery disease and is particularly prevalent in African American women. Chronic stress, associated with discrimination and racism, is linked to CMD. This investigation will evaluate the effectiveness of a novel 8-week, group-based empowerment-building program, Resilience, Stress, and Ethnicity (RiSE), in providing sustainable improvement in well-being, inflammation, and DNA methylation with the potential of decreasing risk for CMD in this high-risk population.

PI_NAMEs: SABAN, KAREN LYNN (contact);TAYLOR, JACQUELYN Y

PROGRAM_OFFICER_NAME: HOOKER, EMILY DIANE

PROJECT_TERMS: acute stress;Address;African American;African American population;African American Women;Age Years;allostatic load;attentional control;Behavioral;Biological;biological adaptation to stress;biopsychosocial;Buffers;C-reactive protein;Candidate Disease Gene;Cardiometabolic Disease;cardiometabolic risk;Cardiovascular Diseases;Cessation of life;Chicago;Chronic;Chronic Disease;Chronic stress;Cognitive;coping;Coping Skills;Coronary Arteriosclerosis;cytokine;Data;depressive symptoms;Development;Discrimination;Disease;disorder risk;DNA;DNA Methylation;DNA Modification Process;effective intervention;effectiveness evaluation;Emotional;empowerment;Environment;Epigenetic Process;Ethnic Origin;Ethnic Population;Exhibits;experience;Face;Fatigue;Gene Expression;Genes;Goals;Health;health disparity;Health education;High Prevalence;high risk population;High Risk Woman;Hypertension;improve minority health;improved;Individual;Inflammation;Inflammatory;Inflammatory Response Pathway;innovation;Interferon Type II;Interleukin-1 beta;Interleukin-6;Intervention;Investigation;life span;Life Stress;Link;Measures;methyl group;Methylation;Minority;Minority Women;Molecular;mortality risk;New York City;novel;Obesity;older women;Outcome;Participant;perceived discrimination;Personal Satisfaction;post intervention;Prediabetes syndrome;Problem Solving;programs;psychologic;psychological distress;Psychological Impact;Psychological Stress;Race;racial identity;racial population;racism;Randomized;Randomized, Controlled Trials;recruit;Reporting;Research;resilience;Resistance;response;Risk;Risk Factors;Salivary;sex;Sexism;Sleep disturbances;Social support;Stress;stress reduction;stressor;Symptoms;theories;TNF gene;Validation;Well in self;Woman;Work

PROJECT_TITLE: The Impact of a Race-Based Stress Reduction Intervention on Well-Being, Inflammation, and DNA methylation in Older African American Women at Risk for Cardiometabolic Disease

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


NIH_SPENDING_CATS: Bioengineering;Data Science;Prevention

PI_NAMEs: PARK, JUW WON (contact)

PROJECT_TERMS: Address;alcohol research;Animals;Area;Basic Science;Bayesian Method;Big Data;Bioinformatics;bioinformatics tool;Biomedical Research;Biometry;Cancer Center;Centers of Research Excellence;Chronic Disease;Clinical;Clinical Data;Clinical Informatics;Clinical Research;cofactor;Communities;community based participatory research;community engagement;Computational Biology;Consultations;Core Facility;cost efficient;Data;Data Analyses;data infrastructure;Dedications;Deposition;design;Diagnosis;Disease;disorder risk;Environment;Environmental Epidemiology;Environmental Exposure;Environmental Health;epidemiology study;Exposure to;Funding;Gender;Genetic;Goals;Grant;Health;health science research;Human;Human Resources;Informatics;Infrastructure;interest;Kentucky;Life;Life Style;lifestyle factors;Measurement;Measures;Mediator;member;Methods;Modeling;Multiomic Data;National Institute of Environmental Health Sciences;Network Infrastructure;patient oriented;Phase;Play;pollutant;Pollution;population health;Population Research;Population Study;pre-clinical;Prevention;Productivity;Public Health;Research;Research Activity;Research Design;Research Infrastructure;Research Personnel;Research Project Grants;Resources;Role;Science;Services;spatiotemporal;statistics;Strategic Planning;Superfund;Techniques;tool;Toxic Environmental Substances;Training;Universities

PROJECT_TITLE: Biostatistics and Informatics Facility Core


PI_NAMEs: MERCHANT, MICHAEL L (contact)

PROJECT_TERMS: Applications Grants;Attention;Award;Awareness;Biometry;Cells;Chronic Disease;citizen science;Collaborations;Communities;community engagement;Core Facility;cost;Data;Data Analyses;Disease;DNA;Environmental Health;environmental toxicology;Equipment;Event;Experimental Designs;Exposure to;Faculty;Funding;Genomics;Goals;Grant;Health;health science research;Health Sciences;Human;Informatics;Inhalation;Inhalation Exposure;Institution;interest;Interest Group;Investments;Laboratories;Life Style;lifestyle factors;Malignant Neoplasms;Measurement;Measures;medical schools;member;Metabolic;metabolomics;Metagenomics;Metals;Modernization;National Institute of Environmental Health Sciences;neurodevelopment;next generation;Organ;Pathologic;Pilot Projects;Pollution;programs;Proteins;Proteomics;Research;Research Design;Research Personnel;Resource Sharing;Resources;RNA;Running;Sampling;Scientist;Services;shared attention;Suggestion;Techniques;Technology;Tissues;Toxic Environmental Substances;toxicant interaction;Toxicogenetics;Toxicology;transcriptomics;Universities;Work

PROJECT_TITLE: Omics and Exposures Facility Core


PI_NAMEs: LEBLANC, AMANDA JO (contact)

PROJECT_TERMS: Accountability;Applications Grants;Area;Award;Benchmarking;career;career development;Categories;citizen science;Collaborations;Communication;Communities;community engagement;community partners;Data Collection;design;Disease;Eligibility Determination;Environmental Exposure;Environmental Health;Event;Experimental Designs;Exposure to;Extramural Activities;Feedback;Fostering;Funding;General Population;Goals;Grant;Grant Review;Health;Human;improved;Individual;Life Cycle Stages;lifestyle factors;Malignant Neoplasms;meetings;member;Mentors;Monitor;National Institute of Environmental Health Sciences;novel;Organ;Pilot Projects;programs;Publications;Recommendation;Reporting;Research;Research Peer Review;Research Personnel;Research Project Grants;Research Support;stem;success;symposium;Technology;Toxic Environmental Substances;Toxicology;Translational Research;Universities;Work

PROJECT_TITLE: PILOT PROJECT


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Eye Disease and Disorders of Vision;Neurofibromatosis;Neurosciences;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: STANFORD

ORG_DEPT: NEUROLOGY

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: Narrative Neuronal activity can promote the growth of high-grade gliomas, but it is not known whether neuronal activity influences low-grade glioma growth or glioma initiation in general. The goal of this proposal is to employ the Neurofibromatosis type 1 (NF1) brain cancer predisposition syndrome as an experimental platform to mechanistically determine whether neuronal activity is a critical driver of low-grade glioma initiation and growth.

PI_NAMEs: GUTMANN, DAVID H;MONJE-DEISSEROTH, MICHELLE  (contact)

PROGRAM_OFFICER_NAME: JHAPPAN, CHAMELLI

PROJECT_TERMS: Accounting;Adult;Age;Attenuated;Biology;Brain;Brain Neoplasms;cancer predisposition;cancer type;Cells;Cessation of life;Child;Childhood;Darkness;Data;Development;Diagnosis;early childhood;Evolution;Exhibits;experimental study;Foundations;Genetic;genetic approach;Germ Lines;Glioma;Gliomagenesis;Goals;Growth;Growth Factor;Histologic;Human;improved;In Vitro;in vivo;inhibitor;Laboratories;Light;light deprivation;light transmission;Maintenance;Malignant neoplasm of brain;Mediating;Modeling;Molecular;Morbidity - disease rate;mouse model;Mouse Strains;Mus;mutant;Mutant Strains Mice;neoplastic cell;Neurocognitive;Neurofibromatosis 1;neuroligin 3;neuronal excitability;Neurons;neurotoxicity;neurotransmission;NF1 gene;NF1 mutation;Optic Chiasm;Optic Nerve;Optic Nerve Glioma;Optics;optogenetics;Outcome;paracrine;Pathogenesis;Pathway interactions;Patients;pediatric low grade glioma;Pediatric Neoplasm;Penetrance;pharmacologic;pre-clinical;prevent;Primary Brain Neoplasms;Production;Proliferating;Regulation;response;Retina;retinal axon;Retinal Ganglion Cells;retinal stimulation;Role;Signal Induction;Signal Transduction;Syndrome;Transcriptional Regulation;tumor;tumor growth;tumor microenvironment;Tumor Suppressor Proteins;tumorigenesis;Visual impairment

PROJECT_TITLE: Neuronal Regulation of Low-Grade Gliomagenesis

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


NIH_SPENDING_CATS: Biomedical Imaging;Brain Disorders;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Depression;Fibromyalgia;Machine Learning and Artificial Intelligence;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Pain Research;Serious Mental Illness

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE This project proposes a novel, multi-target approach for repetitive Transcranial Magnetic Stimulation (rTMS) treatment of Major Depressive Disorder (MDD) and comorbid fibromyalgia (FM), which is associated with significant disability and is highly resistant to treatment. In the short-term, this project aims to evaluate the effectiveness of augmenting rTMS treatment for depression with a secondary target for pain in MDD patients with FM comorbidity and to identify the differences in and the interaction of brain networks affected in MDD and FM using a machine learning approach. In the long-term, this project promises to increase our understanding of this serious comorbid condition and improve treatment outcomes for the subpopulation of patients with MDD and potentially other mood disorder confounded by chronic pain.

PI_NAMEs: CORLIER, JULIANA  (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: Affect;Analgesics;anti-depressive agents;antidepressant effect;associated symptom;Award;Brain;Brief Pain Inventory;career;central pain;chronic pain;Classification;Clinical;comorbidity;Data;Data Set;depressive symptoms;disability;Disabling;Disease remission;Down-Regulation;effectiveness evaluation;efficacy evaluation;efficacy testing;Fibromyalgia;fibromyalgia patients;Functional Magnetic Resonance Imaging;functional MRI scan;Hamilton Rating Scale for Depression;improved;innovation;Joints;Left;Link;Machine Learning;Major Depressive Disorder;Mediating;Mediation;Mental Depression;Mentors;Modeling;Mood Disorders;mood symptom;Motor Cortex;Multimodal Imaging;neural;neuroimaging;neuromechanism;Neuronavigation;neuropsychiatry;neuroregulation;novel;novel strategies;opioid use disorder;Outcome;Output;Pain;Pain Disorder;Pain management;pain processing;pain relief;pain symptom;painful neuropathy;Pathogenesis;Pathway interactions;patient subsets;Patients;Pattern;pharmacologic;Pharmacological Treatment;Prefrontal Cortex;primary outcome;Procedures;Protocols documentation;Quality of life;random forest;Randomized;rate of change;Regulation;repetitive transcranial magnetic stimulation;Research;Research Personnel;Resistance;response;Severities;sham-controlled study;Site;supervised learning;support vector machine;Symptoms;Syndrome;Techniques;Testing;Therapeutic Effect;Training;treatment effect;Treatment Efficacy;treatment group;Treatment outcome;Treatment Protocols;Unemployment

PROJECT_TITLE: Multi-target repetitive Transcranial Magnetic Stimulation (rTMS) treatment for Major Depressive Disorder (MDD) and comorbid pain

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


NIH_SPENDING_CATS: Cancer;Immunotherapy

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: Project Narrative We have proposed a pivotal role of CysLTR1 in regulating tumor-induced MDSC accumulation for both immune suppression and promotion of tumor progression. Our work will not only advance current understandings of how inflammatory lipid mediators in the tumor microenvironment fine-tune emergency myelopoiesis during cancer progression, but will provide the basis for development of novel therapies targeting tumor-infiltrating MDSCs in human cancer.

PI_NAMEs: ZHANG, BIN  (contact)

PROGRAM_OFFICER_NAME: KUO, LILLIAN S

PROJECT_TERMS: Allergic rhinitis;Animals;anti-PD-1;anti-PD-L1;Arachidonic Acids;Asthma;Blood;Bone Marrow;cancer immunotherapy;Cancer Patient;Cell Differentiation process;Cell Line;Cell Physiology;Cell Survival;Cells;Chronic;clinical application;clinical translation;Combined Modality Therapy;cysteinyl leukotriene receptor;cysteinyl-leukotriene;Data;Dendritic Cells;Development;Drug resistance;Emergency Situation;G Protein-Coupled Receptor Signaling;gain of function;Genetic Transcription;Goals;Heterogeneity;Human;Immune Evasion;Immune system;Immune System Diseases;immunoregulation;Immunosuppression;Immunotherapy;improved;In Situ;Infiltration;Inflammation;Inflammatory;Innate Immune System;insight;Leukotriene Antagonists;Link;lipid mediator;Lipoxygenase;loss of function;lymph nodes;Malignant neoplasm of lung;Malignant Neoplasms;Measures;Mediating;Mediator;Melanoma;Melanoma Cell;Metabolism;migration;Modeling;Molds;Molecular;Mus;Myeloid Cells;Myeloid Progenitor Cells;Myeloid-derived suppressor cells;Myelopoiesis;Natural Killer Cells;Nature;neoplasm immunotherapy;Neoplasm Metastasis;neoplastic cell;new therapeutic target;novel;Pathway interactions;Patients;Phenotype;Population;Prognosis;receptor;Receptor Activation;Receptor Signaling;Regimen;Research;Role;selective expression;Series;Signal Pathway;Signal Transduction;Site;Solid Neoplasm;Specimen;T-Lymphocyte;Time;Tissues;Transcriptional Regulation;tumor;Tumor Angiogenesis;Tumor Escape;Tumor Immunity;tumor microenvironment;tumor progression;Tumor Promotion;Tumor-Derived;Work

PROJECT_TITLE: The distinct role of cysteinyl leukotriene receptor for myeloid-derived suppressive cells

STUDY_SECTION: TTT

STUDY_SECTION_NAME: Transplantation, Tolerance, and Tumor Immunology Study Section[TTT]


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Rare Diseases

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

ORG_STATE: NY

PHR: Project Narrative This study will test the hypothesis that tumor cell-intrinsic genetic alterations correlate with response to MEK inhibition in systemic histiocytocytic neoplasms. Although ARAF and MEK1/2 mutations are recurrent across many cancers, the enrichment of these mutations in histiocytoses provides a unique opportunity to functionally dissect mechanisms by which ARAF and MEK1/2 regulate MAPK signaling and drive cancer. The results from this study will improve our understanding of histiocytosis pathogenesis, mechanisms of MAPK pathway activation in cancer, and determinants of response to MEK inhibition.

PI_NAMEs: DIAMOND, ELI LOUS (contact)

PROGRAM_OFFICER_NAME: AGRAWAL, LOKESH

PROJECT_TERMS: Accounting;Adolescent;Adult;Alleles;Biochemical;Biological;Biological Markers;biomarker identification;biomedical referral center;BRAF gene;cell free DNA;Cells;Clinical;clinical practice;Clinical Trials;cohort;Collection;Data;Dependence;Disease;DNA Sequence Alteration;Eosinophilic Granuloma;Erdheim-Chester Disease;Exhibits;falls;Feedback;gain of function;Genes;Genetic;Genomics;Grant;Heterogeneity;histiocyte;Histiocytosis;improved;Individual;inhibitor;innovation;Knowledge;lipogranulomatosis;Macrophage;Malignant Neoplasms;MAP kinase activator;MAP2K1 gene;Measures;Medical center;MEK inhibition;MEKs;Memorial Sloan-Kettering Cancer Center;Mitogen-Activated Protein Kinases;Molecular;monocyte;mutant;Mutate;Mutation;Neoplasms;neoplastic cell;Pathogenesis;Pathway interactions;Patients;Phase II Clinical Trials;Phosphotransferases;Plasma;Plasma Cells;Property;prospective;Protein Isoforms;Publishing;raf Kinases;rare cancer;RAS inhibition;Recurrence;resistance frequency;response;response biomarker;Sampling;Signal Transduction;Sinus histiocytosis;Systemic Therapy;Testing;Therapeutic;Therapy trial;Time;treatment response;United States;Work

PROJECT_TITLE: Molecular Pathogenesis and Therapy of Systemic Histiocytic Neoplasms

STUDY_SECTION: CONC

STUDY_SECTION_NAME: Clinical Oncology Study Section[CONC]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Autoimmune Disease;Diabetes;Eye Disease and Disorders of Vision;Immunotherapy;Neurosciences

ORG_CITY: CLEVELAND

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE Diabetic retinopathy is one of the leading causes of blindness in the working population worldwide. The goal of this research project is to identify therapeutic targets involved in inflammation driven retinal pathogenesis, which will delay the onset of diabetic retinopathy and inhibit vision loss.

PI_NAMEs: TAYLOR, PATRICIA R (contact)

PROGRAM_OFFICER_NAME: GORDIYENKO, NATALIYA

PROJECT_TERMS: Address;Age;Angiogenesis Inhibitors;Autoimmune;Autoimmune Diseases;Background Diabetic Retinopathy;Binding;Biological Assay;Blindness;Blood capillaries;Blood Vessels;Blood-Retinal Barrier;Cell Death;Cells;Chronic;clinically relevant;Complications of Diabetes Mellitus;cytokine;Cytokine Receptors;Data;Diabetes Mellitus;diabetic;Diabetic mouse;Diabetic Retinopathy;Diagnosis;early onset;efficacy evaluation;Endothelial Cells;Epidemic;Event;Extravasation;Gene Silencing;Goals;Health;Human;humanized monoclonal antibodies;Immunoblot Analysis;Immunomodulators;immunoregulation;In Vitro;in vivo;Inflammation;Inflammatory;Inflammatory Response;inhibitor;Interleukin Receptor;Interleukins;Lasers;Lesion;Leukocytes;Link;LoxP-flanked allele;MAPK7 gene;Mediating;Modeling;mouse model;Muller's cell;Mus;Neuroglia;new therapeutic target;novel therapeutics;Oxidative Stress;Oxidative Stress Induction;Pathogenesis;Pathologic;Persons;pharmacologic;Photoreceptors;Play;Population;Prediabetes syndrome;Preventive therapy;Procedures;Production;proliferative diabetic retinopathy;Proteins;Reactive Oxygen Species;receptor;receptor expression;Reporting;Research Project Grants;Retina;Retinal Diseases;Role;Signal Pathway;Signal Transduction;Signaling Protein;small molecule inhibitor;Steroids;Streptozocin;stress activated protein kinase;Subcutaneous Injections;Therapeutic;Therapeutic Intervention;Therapeutic Studies;therapeutic target;TNF Receptor-Associated Factors;TRAF4 gene;TRAF6 gene;trait;Transgenic Mice;Treatment Cost;Type 2 diabetic;type I diabetic;United States;Vascular Permeabilities;Vegf Inhibitor;Vision Disorders;Western World

PROJECT_TITLE: Identification of Immunomodulators for Diabetic Retinopathy Therapeutics


NIH_SPENDING_CATS: Cancer;Genetics;Hematology;Lymphatic Research;Lymphoma;Prevention;Rare Diseases;Women's Health Research

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: NARRATIVE The proposed research is relevant to prevention of hematological malignancies (HM) as there are no current strategies for monitoring or intervening on healthy people with pre disease mutations detectable in blood years before the diagnosis of HM. While it is known that the presence of these mutations increase risk of HM, the exact mutational and cell extrinsic (inflammatory and metabolic) factors that impact the progression of these mutations to HM is not known. At the conclusion of the research study we will be able to delineate a HM specific mutational risk with detailed inflammatory and metabolic pathways that can be utilized for monitoring and creating an interception strategy for HM.

PI_NAMEs: DESAI, PINKAL  (contact)

PROGRAM_OFFICER_NAME: CAGA-ANAN, EMILIE CHARLISSE F

PROJECT_TERMS: Acute Myelocytic Leukemia;adjudication;Age;Age Years;Alleles;Ascorbic Acid;Blood;Blood Banks;Blood specimen;cancer diagnosis;case control;cell growth;Cells;chemokine;Chronic Lymphocytic Leukemia;Clinical;Clinical Trials;Clonal Expansion;cohort;Cohort Studies;comparison control;Data;deep sequencing;Development;Diagnosis;Disease;DNA;DNMT3a;Epidemiology;follow-up;founder mutation;Future;Genes;Genomics;Glucose;Goals;Health Care Costs;Hematologic Neoplasms;Hematology;Hematopoiesis;high risk;improved;Individual;Inflammation;Inflammatory;inflammatory marker;innovation;insight;Intercept;Intervention;JAK2 gene;Kinetics;Large-Scale Sequencing;leukemia;Link;Lymphoma;Malignant Neoplasms;Medicine;Metabolic;Metabolic Pathway;metabolomics;Methods;modifiable risk;Molecular;Monitor;Morbidity - disease rate;mortality;multidisciplinary;Multiple Myeloma;Mutation;Nature;novel;Obesity;Outcome;Participant;Pattern;peripheral blood;Persons;Plasma;population based;Positioning Attribute;pre-clinical;Precancerous Conditions;Predictive Factor;premalignant;Prevalence;prevent;Prevention;Prevention strategy;preventive intervention;prospective;Prospective cohort;Publishing;Randomized, Controlled Trials;Reporting;Research;research study;Risk;Risk Assessment;Risk Factors;risk prediction;Sampling;Shapes;Somatic Mutation;Specimen;Spliceosomes;statistics;Time;TP53 gene;tumorigenesis;United States;Woman;Women's cohort;Women's Health;Work

PROJECT_TITLE: Pre-malignant mutation landscape and risk factors for progression to hematologic cancers

STUDY_SECTION: CHSB

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology B Study Section[CHSB]


NIH_SPENDING_CATS: Bioengineering;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_NAME: DANA-FARBER CANCER INST

PHR: Project Narrative Nuclear magnetic resonance (NMR) spectroscopy is used to study the structure, function, interactions, and dynamics of proteins, with important implications for therapeutic development. However, interpreting NMR information is extremely challenging and labor intensive, especially for large proteins, which produce many overlapping, weak NMR signals. We are developing next-generation methods in which key information is more clearly visible and accessible in the NMR data, using a highly coordinated platform of emerging biochemical, biophysical, mathematical, and computational techniques.

PI_NAMEs: ARTHANARI, HARIBABU  (contact)

PROGRAM_OFFICER_NAME: BARNES, CHARLES ASHLEY

PROJECT_TERMS: Address;Algorithms;Amino Acid Sequence;Amino Acids;artificial neural network;automated analysis;Biochemical;Biological Models;Biophysics;Cell Nucleus;Chemicals;Communities;Computational Technique;Computer software;control theory;cost;COSY;Coupling;Crowding;Cryoelectron Microscopy;Data;design;Dimensions;Drug Design;Environment;experimental study;Fingerprint;Frequencies;G-Protein-Coupled Receptors;Goals;HMQC;Hour;innovation;insight;instrument;Investigation;Isotope Labeling;Isotopes;Label;Machine Learning;Mainstreaming;Mathematics;Measurement;Measures;Medical Research;Methods;methyl group;Mission;Modernization;Molecular Weight;next generation;NMR Spectroscopy;nonlinear regression;novel;novel strategies;Nuclear;Nuclear Magnetic Resonance;nuclear power;Outcome;Pattern;Physiologic pulse;Positioning Attribute;Protein Dynamics;protein function;Protein Glycosylation;Proteins;Pyruvate;quantum;radio frequency;reconstruction;Relaxation;Research;Research Proposals;Resolution;Sampling;Scheme;Science;Shapes;Signal Transduction;Specialist;Spectrum Analysis;Structure;System;Testing;Textbooks;Therapeutic;therapeutic development;Therapeutic Studies;Time;TOCSY;Training;training data;Vertebral column;X-Ray Crystallography

PROJECT_TITLE: NMR Fingerprinting: Leveraging optimal control pulse design, tailored isotope labeling, and machine learning to study intractable proteins

STUDY_SECTION: MSFD

STUDY_SECTION_NAME: Macromolecular Structure and Function D Study Section[MSFD]


ADMINISTERING_IC: LM

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_NAME: UNIVERSITY OF CHICAGO

PHR: PROJECT NARRATIVE When a US hospital system is overwhelmed by disaster, Crisis Standards of Care guide the triage teams forced to choose which patients receive scarce life support treatments in the Intensive Care Unit (ICU). Most US State Crisis Standards of Care rely on the Sequential Organ Failure Assessment (SOFA) score, but SOFA is inaccurate and racially biased. This project will 1) use structural equation modeling to develop an equitable life support allocation (ELSA) score with place-based disadvantage indices and 2) create the ICU Crisis Simulation Model (ICSM), open-source simulation software that evaluates the efficiency and equity of proposed life support allocation protocols.

PI_NAMEs: PARKER, WILLIAM F (contact)

PROGRAM_OFFICER_NAME: YOON, SUNG SUG

PROJECT_TERMS: Adult;Algorithm Design;Algorithms;Area;black patient;Black Populations;Caring;Chicago;Clinical Data;cohort;COVID-19;COVID-19 pandemic;Creatinine;Critical Care;Critical Illness;Data;data enclave;Databases;deprivation;design;Disadvantaged;Disasters;Disparity population;Dose;Electronic Health Record;Ensure;Environment;Equation;Equity;Ethics;Ethnic equity;ethnic minority population;Ethnic Origin;Ethnic Population;Evaluation;evaluation/testing;Event;falls;Geography;health care disparity;Healthcare;Hospitals;improved;indexing;Inequity;Intensive Care Units;Kidney;Laboratories;Legal;Life;Mathematics;Measures;Mechanics;Modeling;models and simulation;Monitor;mortality risk;Nature;neighborhood disadvantage;Neighborhoods;novel;open source;organ allocation;Organ failure;Outcome;Patients;Performance;Pharmaceutical Preparations;Politics;Population Distributions;Probability;Protocols documentation;Public Health;public health ethics;Publishing;Race;racial bias;racial minority population;racial population;Records;residential segregation;Resource Allocation;Resources;Risk;risk prediction;Scoring Method;Series;simulation;simulation software;Site;social;social disparities;social vulnerability;Structure;survival prediction;System;systematic review;Testing;Time;treatment response;Triage;US State;Validation

PROJECT_TITLE: Improving the efficiency and equity of critical care allocation during a crisis with place-based disadvantage indices

STUDY_SECTION: CDMA

STUDY_SECTION_NAME: Clinical Data Management and Analysis Study Section[CDMA]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Homelessness;Physical Injury - Accidents and Adverse Effects;Prevention;Social Determinants of Health;Substance Misuse

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative In the U.S. approximately 70,000 pedestrian injuries and over 6,000 deaths occur annually and pedestrians are commonly under the influence of alcohol when they are injured or killed; approximately 40% of fatally struck pedestrians are under the influence of alcohol at the time they were killed. Current urban planning and design trends and initiatives in the U.S. are likely to place more pedestrians at risk of injury and fatality, particularly pedestrians who are under the influence of alcohol, and current Federal and municipal plans to reduce pedestrian injuries provide no provisions for pedestrians who are under the influence of alcohol. We propose to build web- based geospatial tools to support research on alcohol and pedestrian injury and to conduct a national location- based case-control study of pedestrian fatalities, to answer the questions of whether proximity to retail alcohol outlets, nightlife districts and services for the homeless increase the risk of pedestrian fatality and whether this risk is heightened by built environment features that encourage pedestrian activity, place pedestrians near road traffic and cause distractions.

PI_NAMEs: RUNDLE, ANDREW G (contact)

PROGRAM_OFFICER_NAME: CASTLE, I-JEN

PROJECT_TERMS: Address;Alcohol consumption;alcohol involvement;alcohol risk;Alcohols;annotation  system;application programming interface;Automobiles;billboard;built environment;Businesses;case control;Case/Control Studies;Censuses;Cessation of life;Characteristics;Cities;City Planning;Complex;Computer Assisted;Consumption;Data;design;Development;Development Plans;distilled alcoholic beverage;distraction;Economic Development;Economics;Environment;Geography;Health;Homeless persons;Homelessness;Image;Individual;Infrastructure;injured;Injury;innovation;interest;Intoxication;land use;Licensing;Location;Maps;Measures;method development;modifiable risk;Modification;Municipalities;Neighborhoods;Neon;Online Systems;pedestrian injury;prevent;Public Policy;Reporting;Research;Research Project Grants;Research Support;Restaurants;Risk;Risk Factors;Role;Safety;Sales;Sampling;Services;Shelter facility;Social Environment;statistics;Structure;System;Technology;Testing;Time;tool;Travel;trend;United States;Urban Developments;urban planning;virtual;Visual;Visualization;walkability;Walking

PROJECT_TITLE: Identifying alcohol-related and built environment factors that can be modified to prevent pedestrian road traffic death

STUDY_SECTION: CIHB

STUDY_SECTION_NAME: Community Influences on Health Behavior Study Section[CIHB]


ORG_CITY: Chicago

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: NORTHWESTERN UNIVERSITY

PHR: Project Narrative Transcriptional regulation represents a major control mechanism of gene expression in eukaryotes. Cell-specific expression of ~20,000 genes in human cells requires hundreds of protein factors acting in a multistep manner. Through structural and functional studies, we seek to define the complex molecular mechanisms of gene transcription derived by different RNA polymerases at distinct regulatory steps.

PI_NAMEs: HE, YUAN  (contact)

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TERMS: Address;Architecture;ATP Hydrolysis;Binding;Biochemical;Biogenesis;BRF1 gene;cell growth;Cell Nucleus;Cells;Chemicals;Chromosomes;Code;Complex;Core Assembly;crosslink;Cryoelectron Microscopy;Data;DNA;DNA-Directed RNA Polymerase;Elements;Enhancers;Enzymes;Eukaryota;Gene Expression;Gene Expression Regulation;Gene Proteins;Genes;Genetic;genetic information;Genetic Transcription;Goals;GTF2IRD1 gene;Human;human disease;In Vitro;interdisciplinary approach;Interferon-beta;Mass Spectrum Analysis;Mediator;Molecular;Molecular Biology;novel;Organism;particle;Polymerase;polypeptide;Process;Production;promoter;Protein Biosynthesis;Proteins;reconstitution;recruit;Recycling;Resolution;Ribosomal RNA;RNA;RNA chemical synthesis;RNA Polymerase II;RNA, ribosomal, 25S;RNA, Ribosomal, 5S;rRNA Genes;Series;Signal Pathway;Signal Transduction;Structure;System;TAF1 gene;Techniques;Time;transcription factor;Transcription Factor TFIIA;Transcription Factor TFIIB;transcription factor TFIIE;transcription factor TFIIF;transcription factor TFIIH;Transcription Factor TFIIIA;Transcription Factor TFIIIB;transcription factor TFIIIC;Transcription Initiation;Transcription Initiation Site;Transcriptional Activation;Transcriptional Regulation;Transfer RNA;translocase;Untranslated RNA;Visualization;Yeasts

PROJECT_TITLE: Structure and Mechanism of Eukaryotic Transcription Regulation

STUDY_SECTION: MSFC

STUDY_SECTION_NAME: Macromolecular Structure and Function C Study Section[MSFC]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Cervical Cancer;Clinical Research;Colorectal Cancer;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative Cancer is the leading cause of death for Latino and Asian ethnic groups, who are among the fastest growing U.S. populations. In this study we will pool cancer registry data across five states containing the majority of these populations and link to contextual data to determine which patients live inside ethnic enclaves—distinct neighborhoods with high concentrations of individuals of the same ethnic origin (“co-ethnic residents”), linguistically isolated residents, and immigrants. We will study the relationship among ethnic enclaves, patient nativity (U.S.- or foreign-born) and cancer incidence, stage at diagnosis, survival for three cancer types (breast, cervix, colorectal) for Asian Americans and Latinos, with attention to the 9 major ethnic groups (Cuban, Mexican, Puerto Rican, Chinese, Filipino, Japanese, Korean, South Asian and Vietnamese).

PI_NAMEs: PRUITT, SANDI LEIGH;SHARIFF-MARCO, SALMA  (contact)

PROGRAM_OFFICER_NAME: CRONIN, KATHLEEN A

PROJECT_TERMS: Acceleration;Address;Adopted;American;Asian;Asian Americans;Asian population;Attention;Automobile Driving;Breast;Businesses;California;Cancer Center;Cancer Control;cancer health disparity;cancer prevention;cancer site;cancer type;Cause of Death;Cervix Uteri;Chinese;Collaborations;Colorectal;Colorectal Cancer;Communities;community engagement;Community Outreach;Country;Cuban;Data;data imputation;data registry;design;detection method;Development;Diagnosis;Dimensions;Disparity population;disparity reduction;Early Diagnosis;Emigrations;Ensure;Environment;ethnic minority;Ethnic Origin;Ethnic Population;evidence base;experience;Filipino;Florida;Funding;Future;Geography;Health;health disparity;Health Promotion;Healthcare;Heterogeneity;Immigrant;Immigrant community;Immigration;improved;improved outcome;Incidence;indexing;Individual;Infrastructure;Intervention;Japanese;Joints;Koreans;Latina Population;Latino;Latino Population;Leadership;Linguistics;Link;Literature;Malignant Breast Neoplasm;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Measures;Methodology;Methods;Mexican;minority communities;mortality;multilevel analysis;NCI-Designated Cancer Center;neighborhood disadvantage;Neighborhoods;neoplasm registry;New Jersey;New York;novel;Outcome;Patients;Pattern;Population;population based;Population Growth;Procedures;programs;promote resilience;Puerto Rican;Race;racial minority;Research Personnel;residence;Resources;response;Role;Science;social;social capital;socioeconomic disadvantage;South Asian;Stage at Diagnosis;stressor;Subgroup;surveillance data;Texas;Time;Vietnamese

PROJECT_TITLE: Ethnicity and Nativity in Cancer - Latino & Asian Enclaves: The ENCLAVE Study

STUDY_SECTION: HDEP

STUDY_SECTION_NAME: Health Disparities and Equity Promotion Study Section[HDEP]