NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cardiovascular;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: DALLAS

ORG_DEPT: NEUROLOGY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: The goal of this K24 application is to build a research and training program focusing on investigating the role of the vascular system in Alzheimer’s disease. It includes both career and mentoring plans for new and junior investigators. It also supports 2 research projects that build on ongoing work and add new dimensions to mentoring and patient-oriented research.

PI_NAMEs: HAJJAR, IHAB M (contact)

PROGRAM_OFFICER_NAME: HAAKENSON, CHELSEA MARIE

PROJECT_TERMS: Active Learning;Affect;Age-associated memory impairment;Aging;aging population;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease related dementia;Alzheimer’s disease biomarker;AMD3100;Amyloid beta-Protein;Ancillary Study;Angiotensin Receptor;Animals;antagonist;Area;Autopsy;Biological Markers;biomarker development;Blood Pressure;Blood Vessels;blood-brain barrier permeabilization;Bone Marrow;Brain;Cardiovascular Diseases;career;CD34 gene;Cell Count;Cell Physiology;Cells;Cellular biology;cerebrovascular;Clinical Sciences;Clinical Trials;Cognitive;Cognitive aging;cohort;Conduct Clinical Trials;CXCR4 gene;Data;Dementia;Diabetes Mellitus;Dimensions;Discipline;Disease Marker;Educational Curriculum;Educational process of instructing;endothelial stem cell;Endothelium;Ensure;Environment;Exhibits;Failure;Funding;Future;Gene Expression;Goals;Health;hemodynamics;Hypertension;Immune;Impaired cognition;in vivo;Individual;Inflammatory;interest;Investigation;Leadership;Learning;Link;Lisinopril;Measures;Mentors;Mentorship;Methods;mild cognitive impairment;Molecular;Molecular Analysis;Monitor;Neurosciences;novel;novel therapeutics;Outcome;Participant;Pathway interactions;patient oriented research;Perfusion;peripheral blood;pharmacologic;Pilot Projects;pleiotropism;potential biomarker;Prevention;Process;prodromal Alzheimer's disease;Productivity;programs;Proteins;Proteomics;Reaction;recruit;Regulation;Renin-Angiotensin System;Research;Research Activity;Research Infrastructure;Research Personnel;Research Project Grants;Resources;response biomarker;Risk Factors;Role;Scientist;single-cell RNA sequencing;skills;stem cell function;stem cells;success;tau Proteins;Testing;Therapeutic;Training;Training Activity;Training Programs;transcriptomics;Translational Research;Underrepresented Minority;United States National Institutes of Health;Universities;vascular contributions;vascular factor;Vascular System;Work

PROJECT_TITLE: Mid-Career Program for Vascular Contributions to Alzheimer's disease

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Basic Neuroscience of Aging Study Section[NIA-N]


ADMINISTERING_IC: DK

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Heart Disease;Heart Disease - Coronary Heart Disease;Kidney Disease;Nutrition;Patient Safety;Prevention

ORG_CITY: SEATTLE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE Activated vitamin D use in kidney failure is ubiquitous, costly, and almost certainly has important effects on outcomes. Yet, the high vitamin D doses encouraged by the current treatment paradigm pose substantial potential risks and optimal dosing strategies have not been adequately assessed. Advancing this field has the potential to improve safety, cardiovascular outcomes, and treatment costs for the millions of patients worldwide with kidney failure.

PI_NAMEs: HSU, SIMON  (contact)

PROGRAM_OFFICER_NAME: GREER, RAQUEL CHARLES

PROJECT_TERMS: Acceleration;acceptability and feasibility;Adherence;Agonist;Alkaline Phosphatase;Animals;arterial stiffness;Benefits and Risks;biomarker panel;Blood Vessels;bone;Bone Diseases;bone turnover;calcification;Calcitriol;Calcium;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;Cardiovascular system;career development;Caring;Chronic Kidney Failure;cinacalcet;Clinical;clinical epidemiology;clinical practice;Clinical Trials;comparative efficacy;comparative safety;Complement;Complex;coronary perfusion;cost;Databases;Deposition;design;Development Plans;Dialysis procedure;Discipline of Nursing;Disease;Dose;Electronic Health Record;Enrollment;epidemiologic data;Epidemiology;Event;experience;fibroblast growth factor 23;Foundations;Future;Goals;Harm Reduction;Health Benefit;Hemodialysis;hospitalization rates;Hydroxyapatites;Hypercalcemia;Hyperparathyroidism;improved;In Vitro;inorganic phosphate;Interruption;Intervention;Intervention Trial;Intravenous;intravenous administration;Kidney;Kidney Failure;Left Ventricular Hypertrophy;Maintenance;Measures;meetings;Mentors;Metabolic;Metabolism;Minerals;mortality risk;multidisciplinary;Normal Range;Oral;Osteogenesis;osteogenic;Outcome;Participant;Pathologic;patient oriented;Patients;Pharmaceutical Preparations;Physicians;Positioning Attribute;practice setting;pragmatic trial;prevent;primary outcome;Process;promoter;Provider;PTH gene;public health research;randomized, clinical trials;Research;Research Design;Research Personnel;Retrospective cohort study;Risk;Safety;safety testing;Scientist;Serum;skills;Smooth Muscle Myocytes;Structure;symposium;synergism;Testing;Titrations;Training;translational health science;treatment as usual;Treatment Cost;treatment strategy;trial design;Vascular calcification;Vascular Smooth Muscle;Vitamin D;Vitamin D3 Receptor

PROJECT_TITLE: Comparative Safety and Efficacy of Low-dose Vitamin D in Kidney Failure

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Genetics;Human Genome;Prevention

ORG_CITY: Columbus

ORG_DEPT: GENETICS

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Project narrative Cancers are characterized by deletions of chromosomal regions some of which can inactivate cell cycle regulators while the role of others is not known. This proposal investigates the role of PRMT5, a gene central to cellular proliferation and carcinogenesis, in suppressing chromosomal deletions in human cells. Successful completion of the proposed experiments will delineate new mechanisms of cellular transformation and carcinogenesis.

PI_NAMEs: BOULEY, RENEE ;PETREACA, RUBEN CIPRIAN (contact)

PROGRAM_OFFICER_NAME: SHARMAN, ANU

PROJECT_TERMS: Acetyltransferase;Active Sites;Affect;analog;arginine methyltransferase;artificial intelligence algorithm;Automobile Driving;Biochemical;Biological Assay;Biological Models;brca gene;BRCA1 gene;BRCA2 gene;cancer cell;carcinogenesis;Catalogs;Cell Cycle;Cell Proliferation;Cells;chromatin remodeling;Chromosomal Rearrangement;Chromosome abnormality;Chromosome Deletion;Complex;Data;design;Development;Direct Repeats;DNA annealing;DNA Damage;DNA Double Strand Break;DNA Repair;Double Strand Break Repair;driver mutation;Elements;enzyme activity;Enzymes;Eukaryota;Event;Evolution;Excision;experimental study;Fission Yeast;Frequencies;Gene Expression Regulation;gene repair;Generations;Genes;Genetic;genetic information;Genetic Recombination;Goals;Histones;homologous recombination;Homology Modeling;HTATIP gene;Human;In Vitro;in vivo;innovation;Link;Malignant Neoplasms;Maps;Mediating;metaplastic cell transformation;Methylation;Methyltransferase;Mitosis;Modeling;mutant;Mutate;Mutation;Mutation Analysis;Mutation Detection;neoplastic cell;Nonhomologous DNA End Joining;Pathogenicity;Pathway interactions;Peptides;Pharmaceutical Preparations;Post-Translational Protein Processing;prevent;Process;RAD52 gene;recombinational repair;repaired;Repetitive Sequence;Reporting;response;Role;S phase;Side;small molecule inhibitor;Somatic Mutation;Techniques;Testing;Validation;Work;yeast genetics;Yeasts

PROJECT_TITLE: The role of PRMT5 in preventing intra-chromosomal deletions in cancer cells


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: CHICAGO

ORG_DEPT: SURGERY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative Transplantation is the only treatment for patients suffering from end-stage organ failure and early injuries in the donor organ are attributed to long-term failure. New therapeutic strategies are needed to mitigate early injuries and improve organ transplantation outcomes. The endothelium in the donor organ is central to early injuries and therefore, we seek to investigate the role of protecting the endothelial barrier in mitigating early insults.

PI_NAMEs: NADIG, SATISH N (contact)

PROGRAM_OFFICER_NAME: KEHN, PATRICIA J

PROJECT_TERMS: Acute;adaptive immune response;Affect;Allografting;Antigen Presentation;Antigen-Presenting Cells;Blood Vessels;Brain Death;Brain Hypoxia-Ischemia;Cardiac;Cell Adhesion Molecules;Cell Communication;cell injury;Cell Line;Cells;Cellular Structures;clinical translation;clinically relevant;Communication;Connexin 43;Connexins;Cryopreservation;cytokine;Data;end-stage organ failure;Endothelial Cells;Endothelium;experimental study;Failure;Funding;Gap Junctions;Genetic;graft failure;graft function;Graft Rejection;Graft Survival;Health;Heart;Heart Transplantation;high reward;high risk;Homeostasis;Immune;immune activation;immunogenicity;Immunosuppression;implantation;improved;In Vitro;in vitro Model;in vivo;Inflammatory;injured;Injury;Innate Immune Response;innovation;insight;intercellular cell adhesion molecule;Intercellular Junctions;Ischemia;ischemic injury;isoimmunity;knock-down;Laboratories;Longevity;Mainstreaming;Maintenance;Mediating;Messenger RNA;Modeling;Modification;mouse model;Mus;Neutrophil Infiltration;novel;novel therapeutic intervention;Organ;Organ Donor;Organ Preservation;Organ Transplantation;Outcome;overexpression;Patients;Penetration;Peptides;Perioperative;pharmacologic;Phase;Phenotype;Phosphorylation;pre-clinical;preservation;prevent;Proteins;Publishing;Regimen;Reperfusion Injury;Reperfusion Therapy;response;Role;Signal Pathway;Signal Transduction;Solid;standard of care;Surface;T memory cell;Testing;therapeutic target;Transplantation;Treatment Protocols;treatment strategy;Vascular Cell Adhesion Molecule-1;Vascular Endothelial Cell;Vascular Permeabilities

PROJECT_TITLE: Ex vivo maintenance of endothelial cell barrier integrity via gap junction modification to prevent early ischemic injury in solid organ transplantation

STUDY_SECTION: TTT

STUDY_SECTION_NAME: Transplantation, Tolerance, and Tumor Immunology Study Section[TTT]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Cancer;Brain Disorders;Cancer;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Nutrition;Obesity;Orphan Drug;Pediatric;Pediatric Cancer;Precision Medicine;Prevention;Rare Diseases

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

PHR: NARRATIVE Hypothalamic obesity is a treatment-resistant form of obesity that affects survivors of hypothalamic brain tumors. In this pilot clinical trial, we will collect important safety and efficacy data and thereby lay the groundwork for a larger innovative sequential multiple assignment randomized trial (SMART) in the future. The overall goal is to understand individual responses to obesity interventions, and to personalize therapeutic interventions based on the individual initial responses utilizing different drugs with demonstrated safety and potential efficacy in HO.

PI_NAMEs: MCCORMACK, SHANA ERIN;ROTH, CHRISTIAN LUDWIG (contact)

PROGRAM_OFFICER_NAME: OSGANIAN, VOULA

PROJECT_TERMS: Address;Adolescent;Adolescent and Young Adult;Adult;Adverse event;Affect;Age;Agonist;alertness;Anxiety;arm;attenuation;Biological;biomarker identification;Body fat;Body mass index;Body Weight decreased;Brain Neoplasms;capsule;Cardiometabolic Disease;Caregivers;Case Study;Child;Childhood Brain Neoplasm;Clinical Trials;Cognition;Combined Modality Therapy;Cross-Over Studies;Data;design;Desire for food;Disease;Dose;dose individualization;Double-Blind Method;Drug usage;Dual-Energy X-Ray Absorptiometry;Eating;Eating Behavior;Energy Metabolism;Epilepsy;Event;Excess Mortality;Excessive Daytime Sleepiness;Exclusion Criteria;exenatide;experience;Fatigue;FDA approved;Feasibility Studies;Foundations;Froehlich's Syndrome;Future;GLP-I receptor;Goals;Health;Heterogeneity;Hyperphagia;Hypothalamic Neoplasms;Hypothalamic structure;Impairment;impression;improved;Impulsivity;inclusion criteria;Individual;individual response;Injury;innovation;Intervention;Interview;Magnetic Resonance Imaging;Maintenance;Maximum Tolerated Dose;Measures;Metabolic;metabolic phenotype;metabolic rate;Mission;mortality risk;Multi-Institutional Clinical Trial;National Institute of Diabetes and Digestive and Kidney Diseases;novel therapeutics;Obesity;obesity treatment;Older Population;Oral;Outcome;Oxytocin;Participant;personalized approach;personalized therapeutic;Persons;Pharmaceutical Preparations;pharmacologic;Phase;phase 2 study;Phentermine;Physical activity;Pilot Projects;pilot trial;Placebo Control;placebo controlled trial;Placebos;Pre-Clinical Model;prevent;Procedures;programs;Protocols documentation;Randomized;randomized placebo-controlled clinical trial;recruit;Regulation;Reporting;Research;Resistance;response;Safety;safety assessment;Sample Size;Sampling;Sequential Multiple Assignment Randomized Trial;sibutramine;Stimulant;stimulant use;Structure;subcutaneous;success;Suggestion;Survivors;Sympathomimetic Amines;Testing;Therapeutic Intervention;Titrations;topiramate;treatment effect;treatment planning;treatment response;treatment strategy;trial design;Visceral fat;Weight Gain;Withdrawal

PROJECT_TITLE: Phentermine/Topiramate in children, adolescents, and young adults with hypothalamic obesity: a pilot and feasibility study

STUDY_SECTION: HSDO

STUDY_SECTION_NAME: Human Studies of Diabetes and Obesity Study Section[HSDO]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cystic Fibrosis;Genetics;Human Genome;Lung;Machine Learning and Artificial Intelligence;Rare Diseases

ORG_CITY: LA JOLLA

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

ORG_STATE: CA

PHR: Narrative: We address the unmet challenge in mechanistically understanding how human variation contributes to genetic disease through rigorous experimental and computational approaches. We will apply variation spatial profiling (VSP) and variation capture (VarC), approaches that use Gaussian process (GP) machine learning to define quantitatively spatial co-variance (SCV) relationships that rigorously link on a residue-residue basis the genotype to its basic function(s) and clinical phenotype(s) at atomic resolution. We will mechanistically dissect the role of proteostasis components, the cellular protein folding machinery, in the management of naturally occurring genetic variation for presentation to the COPII components Sar1, Sec12, Sec16, Sec23/24, Sec13/31 to understand the integrated events triggering for human pathophysiology, setting the stage for a quantitative global platform for describing clinical disease and its management based on the common biological principle of SCV.

PI_NAMEs: BALCH, WILLIAM EDWARD (contact)

PROGRAM_OFFICER_NAME: LACHOWICZ-SCROGGINS, MARRAH ELIZABETH

PROJECT_TERMS: Address;Affect;Amino Acid Sequence;Automobile Driving;Biological;Biology;Cell surface;Cells;Chemicals;Clinic;Clinical;clinical phenotype;ClinVar;Code;computer framework;Cystic Fibrosis;cystic fibrosis patients;Cystic Fibrosis Transmembrane Conductance Regulator;Delta F508 mutation;design;Disease;Endoplasmic Reticulum;Environment;Event;Evolution;fitness;Foundations;Functional disorder;functional improvement;functional restoration;gain of function;Genetic;Genetic Diseases;genetic variant;Genetic Variation;Genome;genomic variation;Genomics;Genotype;Goals;Golgi Apparatus;Health;healthspan;Human;Human Biology;human disease;Human Genetics;in silico;Individual;Inherited;Link;Logistics;loss of function;Machine Learning;Membrane;Membrane Protein Traffic;misfolded protein;Modeling;Molecular;Molecular Chaperones;Mutation;new technology;novel;Paper;Pathway interactions;patient population;phenome;Phenotype;polypeptide;Population;Predisposition;Process;programs;Protein Engineering;protein folding;protein function;protein structure;Proteins;proteostasis;Publications;Reporting;Resolution;response;Role;screening;Severities;Severity of illness;small molecule;small molecule therapeutics;spatial relationship;statistics;Structure;System;Technology;Therapeutic;Time;trafficking;Uncertainty;Validation;Variant

PROJECT_TITLE: Applying Spatial Covariance to Understand Human Variation in Genetic Disease

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biodefense and Related Countermeasures;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Coronaviruses;Emerging Infectious Diseases;Infectious Diseases;Neurosciences;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: Project narrative A core symptom among the post-acute sequelae of COVID-19 (PASC) is 'brain fog,' which involves a disruption of cognitive control executive functioning. With dual MRI-PET (magnetic resonance imaging - positron emission tomography) neuroimaging, we will use multiple complimentary techniques to probe the function of the anterior midcingulate cortex (aMCC) in PASC during a cognitive control task. Functional MRI will detect the aCC voxel with peak blood oxygen level-dependent (BOLD) response while simultaneous [11C]PBR28 scanning will measure microglial activation within that voxel and subsequent magnetic resonance spectroscopy (MRS) will measure metabolite concentrations.

PI_NAMEs: VANELZAKKER, MICHAEL B (contact)

PROGRAM_OFFICER_NAME: BABCOCK, DEBRA J

PROJECT_TERMS: 21 year old;Anatomy;Anterior;Applications Grants;Attention;Autoantibodies;Behavioral;behavioral response;Bilateral;Biological Markers;Blood;blood oxygen level dependent;Blood specimen;Blood Vessels;Brain;brain fog;case control;Cerebrovascular system;Chemicals;Choline;Chronic Fatigue Syndrome;Coagulation Process;cognitive control;cognitive task;Consensus;COVID-19;COVID-19 pandemic;Creatine;Data;Data Correlations;distraction;executive function;Functional Magnetic Resonance Imaging;Future;glial activation;Home;Image;Impairment;Individual;Inflammation;Inflammatory;interest;International;Left;Link;Magnetic Resonance Imaging;Magnetic Resonance Spectroscopy;Measures;microbiome;Modality;MRI Scans;neural;neuroimaging;Neurologic;Parietal Lobe;Participant;Patient Self-Report;Performance;Positron-Emission Tomography;Post-Acute Sequelae of SARS-CoV-2 Infection;Prefrontal Cortex;Publications;radioligand;recruit;Reporting;response;Saliva;saliva sample;SARS-CoV-2 infection;Scanning;Severities;sleep quality;Source;Symptoms;Syndrome;systemic inflammatory response;Techniques;Testing;Time;uptake;Visit;wearable device;World Health Organization

PROJECT_TITLE: Glial activation and metabolite contributions to 'brain fog' post-acute sequelae of COVID-19 (PASC)

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


ADMINISTERING_IC: MD

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Drug Abuse (NIDA only);HIV/AIDS;Substance Misuse

ORG_CITY: NASHVILLE

ORG_NAME: MEHARRY MEDICAL COLLEGE

ORG_STATE: TN

PI_NAMEs: ADUNYAH, SAMUEL EVANS (contact);CAO, AIZE

PROGRAM_OFFICER_NAME: DAS, RINA

PROJECT_TITLE: Admin Core


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Genetics;Human Genome;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Radiation Oncology;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: Aurora

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative Pediatric high-grade glioma (PHGG), a deadly childhood brain tumor, likely originates from tumor stem  cells that differentiate into proliferating tumor cells. PHGG tumors are heterogeneous and include several  different types of proliferating cells, leading to the question of how tumor stem cells and proliferating tumor  cells relate to one another. I will investigate whether a single multipotent tumor stem cell population  produces the multiple proliferating cell types of PHGG, to provide a biological foundation for the  development of critically needed advances in therapeutic alternatives for this deadly childhood disease.

PI_NAMEs: DESISTO, JOHN A (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: Astrocytes;Biologic Characteristic;Biological;cell growth;Cell Maintenance;Cell Proliferation;Cell Survival;cell type;Cells;Characteristics;chemotherapy;Childhood;Childhood Brain Neoplasm;childhood cancer mortality;Childhood Central Nervous System Neoplasm;Childhood Glioma;Clinical Trials;Complementary DNA;Control Groups;Copy Number Polymorphism;Data;Development;diffuse midline glioma;Disease;DNA sequencing;drug candidate;Drug Screening;effective therapy;Effectiveness;Foundations;Genes;Goals;Growth;Heterogeneity;Histology;Histones;in vivo;Individual;Institution;Investigation;knock-down;Knowledge;lentivirally transduced;Lysine;Malignant Neoplasms;Mediating;Methionine;Methods;Molecular;mouse model;Mus;Mutation;neoplastic cell;neural;Normal Cell;Nucleotides;oligodendrocyte progenitor;Oncogenic;Operative Surgical Procedures;Pathway interactions;patient derived xenograft model;Patients;Pattern;Pharmaceutical Preparations;pharmacologic;Phenotype;Play;Population;Population Decreases;Postdoctoral Fellow;pre-doctoral;Predisposition;progenitor;Proliferating;radiation effect;Radiation therapy;Radiation-Sensitizing Agents;Recurrence;Research;Resistance;resistance mechanism;Role;Sampling;self-renewal;single cell analysis;single cell genomics;single-cell RNA sequencing;small hairpin RNA;Somatic Mutation;stem;stem cell differentiation;stem cell population;stem cells;Survival Rate;Testing;Therapeutic;Therapeutic Effect;therapy design;therapy resistant;tool;tumor;Tumor Bank;Tumor Biology;tumor growth;tumor heterogeneity;tumor initiation;Tumor Stem Cells;tumor xenograft;tumorigenesis;Variant;Work;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Investigation of tumor stem cell maintenance and cellular hierarchy in pediatric high-grade glioma


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Patient Safety;Pediatric;Pediatric Cancer;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases;Social Determinants of Health

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: PROJECT NARRATIVE Pediatric cancer survivors (PCS) experience an excess risk of numerous adverse outcomes related to their cancer diagnosis and treatment, which impact social functioning, quality of life, and health care resource utilization. Latinos, in particular, are more likely to experience these adverse outcomes and have reduced access to routine medical care, contributing to higher morbidity and mortality among Latino children diagnosed with cancer. Existing and well-established cohorts of PCS exclusively include long-term survivors with a relatively small proportion of Latino PCS; therefore, the data that inform our understanding of risk for treatment-related late effects, our clinical practice guidelines to address them, and the uptake of survivorship care in this vulnerable and growing population are deficient.

PI_NAMEs: GRAMATGES, MARIA MONICA;KAHALLEY, LISA SCHUM;SCHEURER, MICHAEL E. (contact)

PROGRAM_OFFICER_NAME: BURNETT, ANDREA NICOLE

PROJECT_TERMS: Acute;Address;Adolescent;Adverse event;adverse outcome;Affect;Age;Area;Behavioral;behavioral outcome;biobank;Blood;cancer diagnosis;cancer epidemiology;Cancer Patient;Cancer Relapse;cancer risk;Cancer Survivorship;cancer therapy;Caring;Cells;Child;childhood cancer survivor;Chronic;Clinical;Clinical Practice Guideline;clinical risk;cohort;Data;data repository;Databases;deprivation;Diagnosis;Disparity;Education;Epidemiology;ethnic diversity;Ethnic Population;evidence based guidelines;experience;Financial Hardship;follow-up;Foundations;functional outcomes;Genetic;genetic epidemiology;Genomics;Geography;Guidelines;Health;Health Insurance;Health Services Accessibility;Healthcare;high risk;indexing;Institution;Insurance Coverage;Intervention;Late Effects;Latino;Latino Population;Link;Long-Term Survivors;Low income;low socioeconomic status;Malignant Childhood Neoplasm;Malignant Neoplasms;Medical;metabolomics;Molecular;Morbidity - disease rate;mortality;multidisciplinary;Native American Ancestry;Neurocognitive;Not Hispanic or Latino;Outcome;outcome disparities;participant enrollment;Patients;Pediatric cohort;Pediatric Oncology;peer;Phase;Population;Population Heterogeneity;Poverty;Predisposition;prospective;Prospective cohort;psychological outcomes;psychosocial;Quality of life;racial population;Recurrence;Relapse;Reporting;Resources;Risk;Risk Assessment;Risk Factors;Saliva;Sampling;Services;Severities;Social Functioning;sociodemographics;Socioeconomic Status;socioeconomics;Specimen;success;Survivors;survivorship;Symptoms;synergism;Texas;Time;Toxic effect;Treatment outcome;treatment risk;Treatment-related toxicity;tumor;Underrepresented Minority;Unemployment;Uninsured;United States;uptake;Urine;Work

PROJECT_TITLE: Survivorship and Access to care for Latinos to Understand and address Disparities (SALUD)


ORG_CITY: LOS ANGELES

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

PHR: PROJECT NARRATIVE Heart failure (HF) remains a leading cause of cardiovascular mortality and morbidity that results in a poor quality of life and reduced lifespan. Renal denervation (RDN) is a powerful, device-based treatment for patients with severe hypertension for whom drug therapies have failed. We will investigate the beneficial effects of RDN in a clinically relevant animal model of HF and the results of these studies will guide the development of novel HF treatments.

PI_NAMEs: GOODCHILD, TRACI TAYLOR (contact)

PROGRAM_OFFICER_NAME: SCHWARTZ, LISA

PROJECT_TERMS: Acetates;Adult;aging population;Aldosterone;Angiotensin I;Angiotensin II;Animal Model;Animals;Attenuated;Bilateral;Biochemical;Biological Markers;Blood Pressure Monitors;Blood Vessels;candidate identification;Cardiac;cardioprotection;Cardiovascular system;Catheters;Cholesterol;Chronic;Clinical;clinically relevant;comorbidity;Conscious;Coronary;cortical catecholamine;Coupled;Denervation;density;Deoxycorticosterone;Development;Devices;Diabetes Mellitus;diabetic;Diagnosis;Diet;Disease Progression;Down-Regulation;effective therapy;EFRAC;Endothelium;exercise capacity;exercise intolerance;experimental study;Fatty acid glycerol esters;FDA approved;Fibrosis;follow-up;Fructose;Functional disorder;gene panel;Genomics;Harvest;Heart;Heart failure;hemodynamics;Histologic;hypercholesterolemia;Hypertension;hypertensive;Implant;improved;In Vitro;Kidney;kidney cortex;kidney dysfunction;Left;Left ventricular structure;life span;Lung;Measures;Mediator;Medical;Medicine;Metabolic;Metabolic syndrome;metabolomics;Mineralocorticoids;Miniature Swine;Morbidity - disease rate;mortality;Myocardial;Myocardial tissue;Nerve;Norepinephrine;novel;novel therapeutics;Obesity;Organ;Pathologic;Pathology;Patients;Pharmacotherapy;Physiologic intraventricular pressure;Physiological;Plasma;porcine model;pre-clinical;preservation;Prevalence;prevent;protective effect;Proteomics;Public Health;Quality of life;radio frequency;renal artery;Renal Tissue;Renin;repaired;RNA Sequences;Severities;sex;Signal Transduction;Skeletal Muscle;Sodium Chloride;Stains;Sympathetic Nervous System;System;Therapeutic;therapeutic target;Time;Tissues;Treadmill Tests;Treatment Failure;Tyrosine 3-Monooxygenase;Ultrasonic Therapy;ultrasound;vascular injury;Ventricular;western diet;Work

PROJECT_TITLE: Renal Denervation in Heart Failure with Preserved Ejection Fraction

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-TDPS-R(01)]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Biotechnology;Chronic Liver Disease and Cirrhosis;Congenital Structural Anomalies;Digestive Diseases;Facioscapulohumeral Muscular Dystrophy;Genetics;Liver Disease;Muscular Dystrophy;Nutrition;Orphan Drug;Pediatric;Prevention;Rare Diseases

ORG_CITY: COLUMBUS

ORG_NAME: RESEARCH INST NATIONWIDE CHILDREN'S HOSP

PHR: PROJECT NARRATIVE X-linked myotubular myopathy (XLMTM) is a rare neurogenetic disorder associated with severe clinical symptoms and early death that is currently without treatment. Non-alcoholic steatohepatitis (NASH) is a prevalent liver condition that does not have adequate therapy and that can progress to liver failure, cancer, and death. Inhibition of the enzyme PIK3C2B may surprisingly be a therapeutic strategy for both XLMTM and NASH, and the goal of this proposal is to develop and test an miRNA-based PIK3C2B knockdown therapeutic as a treatment for both of these conditions.

PI_NAMEs: DOWLING, JAMES J;HARPER, SCOTT Q (contact)

PROGRAM_OFFICER_NAME: CARIFI, EMILY FORAN

PROJECT_TERMS: 1-Phosphatidylinositol 4-Kinase;Adult;Affect;American;Animals;Birth;Body Weight decreased;C2 Domain;Cessation of life;Charcot-Marie-Tooth Disease;Chemicals;Childhood;Cirrhosis;Clinical;clinical translation;comorbidity;Data;delivery vehicle;Dependence;Deposition;Development;Diet;disability;Disease;efficacy evaluation;Endosomes;Enteral Feeding;Enzyme Inhibition;Exercise;Exploratory/Developmental Grant;Facioscapulohumeral;Facioscapulohumeral Muscular Dystrophy;Fatty acid glycerol esters;Fatty Liver;fatty liver disease;Functional disorder;gene therapy;Genes;Genetic;genetic approach;Goals;Hepatobiliary;Human;improved;In Vitro;in vivo;Individual;infancy;inhibitor;insulin sensitivity;knock-down;Knock-out;knockout gene;Knockout Mice;Life;Liver;Liver diseases;Liver Failure;Malignant neoplasm of liver;Malignant Neoplasms;Mediating;metabolic phenotype;metabolic profile;Metabolism;MicroRNAs;Modeling;Molecular;mouse model;Mus;Muscle;Muscle hypotonia;Mutation;Natural History;neurogenetics;Neuromuscular Diseases;non-alcoholic;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;novel;novel therapeutics;Organ;overexpression;Pathology;patient subsets;Patients;Phenocopy;Phenotype;phosphatidylinositol phosphate 4-kinase;Phosphotransferases;PIK3CG gene;PMP22 gene;Positioning Attribute;Pre-Clinical Model;prevent;Process;promoter;Proteins;rare condition;Reducing diet;Regulation;Reporting;Risk;RNA;Role;Skeletal Muscle;success;Survivors;Symptoms;Testing;Therapeutic;Therapeutic Uses;therapy development;Time;trafficking;Translating;Translations;Ventilator;Vesicle;Weight Gain;Wheelchairs;Wild Type Mouse;X-linked myotubular myopathy

PROJECT_TITLE: AAV mediated gene knockdown of PIK3C2B as a therapeutic strategy for X-linked myotubular myopathy and fatty liver disease

STUDY_SECTION: TAG

STUDY_SECTION_NAME: Therapeutic Approaches to Genetic Diseases Study Section[TAG]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Sleep Research;Social Determinants of Health

PHR: PROJECT NARRATIVE This project will develop and validate a computable phenotype algorithm for classifying pediatric sleep deficiency. Furthermore, postprocessing bias mitigation methods will be applied to build and test an equitable computable phenotype model across subpopulations defined by age, gender, race/ethnicity, and socioeconomic status. This innovative K01 research and training plan will equip me with the new skills necessary to become an independent investigator in pediatric sleep research and population health science, prepared to work in interdisciplinary clinical and technical teams.

PI_NAMEs: DAVENPORT, MATTINA ASHLEY (contact)

PROGRAM_OFFICER_NAME: DIXIT, SHILPY

PROJECT_TERMS: Address;Adolescent;Age;Aggregation Bias;alertness;Area;Artificial Intelligence;Behavior;biomedical informatics;career;career development;Caring;Characteristics;Child health care;Childhood;Classification;classification algorithm;Clinical;cohort;computable phenotypes;cost effective;Data;Data Set;data sharing networks;Databases;design;Detection;Development;Diagnosis;Diagnostic;Dimensions;Disease;Disease Management;Disparity;disparity gap;Disparity population;Drowsiness;electronic data;Electronic Health Record;Ensure;Equity;Ethnic Origin;experience;Future;Gender;Geography;Goals;health care settings;health disparity;health equity;Health Sciences;Health system;improved;improvement on sleep;innovation;interest;Knowledge;Learning;learning network;Machine Learning;marginalization;Measurement;medical specialties;Medicine;member;Mentored Research Scientist Development Award;Mentors;Mentorship;Methods;minority children;Modeling;Napping;National Heart, Lung, and Blood Institute;National Institute on Minority Health and Health Disparities;novel;Parents;patient subsets;Patients;Pediatric Hospitals;Performance;Phenotype;poor sleep;Population;population health;Predisposition;Prevalence;Process;Public Health;Race;racial minority;Reporting;Research;Research Personnel;Resources;responsible research conduct;satisfaction;School-Age Population;screening;screening disparities;Screening procedure;Sensitivity and Specificity;Services;skills;Sleep;Sleep Deprivation;Sleep Disorders;Sleep disturbances;sleep health;Socioeconomic Status;Source;Structure;Subgroup;Technology;Testing;tool;Training;Translating;underserved community;Underserved Population;United States National Institutes of Health;Validation;Work;Writing

PROJECT_TITLE: Development and Validation of an Equitable Computable Phenotype for Classifying Pediatric Sleep Deficiency in Electronic Health Records


NIH_SPENDING_CATS: Digestive Diseases;Food Allergies;Nutrition;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: ANN ARBOR

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Food allergy is rapidly increasing in prevalence affecting up to 6 million American children at an economic cost of ~$25 billion per year. Currently there is an FDA-approved treatment for peanut allergy, however there are no approved treatments for other food allergies (shellfish, milk, tree nuts, egg, wheat, soy and sesame) which affect ~23.2 million Americans. Successful completion of the proposed studies will identify key cellular and molecular processes in the passage of dietary antigens to the gastrointestinal compartment and the priming for clinical reactivity to foods, thereby directing development of new and pre-existing therapeutics for treating all food allergies.

PI_NAMEs: HOGAN, SIMON PATRICK (contact);NEWBERRY, RODNEY D

PROGRAM_OFFICER_NAME: SUBRAMANIAN, HARIHARAN

PROJECT_TERMS: Ablation;Adjuvant;Adult;Affect;Allergic;Allergic Reaction;Allergy to peanuts;American;Anaphylaxis;Antigen-Presenting Cells;Antigens;Basophils;CD3 Antigens;CD4 Positive T Lymphocytes;Cell Communication;Cells;Centers for Disease Control and Prevention (U.S.);Cessation of life;Child;Cholera Toxin;Clinical;Complex;conditioning;crosslink;cytokine;Development;dietary;economic cost;egg;Exposure to;FDA approved;filaggrin;Food;food allergen;food antigen;food avoidance;Food Hypersensitivity;Frequencies;Funding;gastrointestinal;Gastrointestinal tract structure;Genes;Genetic;Goblet Cells;Human;IgE;IL18 gene;Immune;Immune Tolerance;Immunologics;imprint;Individual;Inflammatory;Inflammatory Response;Interleukin-13;Interleukin-4;intestinal epithelium;Knowledge;Lamina Propria;Link;mast cell;Mechanics;Mediating;Milk;Modeling;Molecular;mouse model;Mus;Nuts;Oral;Organism;Organoids;Outcome;Pathogenicity;Pattern;Phenotype;Population;Prevalence;Prevention;Process;Production;Property;Proto-Oncogene Protein c-kit;Reaction;recruit;Reporter;response;Role;Sesame - dietary;Shellfish;Signal Induction;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Skin;skin barrier;Skin injury;Small Intestines;soy;System;T cell response;Technology;Testing;Th2 Cells;Therapeutic;therapeutic target;Trees;Tropism;TSLP gene;two photon microscopy;Visit;Wheat

PROJECT_TITLE: Pro-Type 2 Goblet Cell Antigen Passages in Food Sensitization and Reactivity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IIDB-K(57)]


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Digestive Diseases;Inflammatory Bowel Disease

ORG_CITY: NEW YORK

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: PROJECT NARRATIVE Inflammatory bowel disease (IBD) is a chronic immune-mediated disease that impacts over 3 million Americans, represents a major socio-economic health challenge, and currently has limited preventative, therapeutic or curative treatment strategies. Basic, translational, and clinical studies defined a key role for the pro-inflammatory factor, tumor necrosis factor (TNF), in driving cell death in the intestinal epithelium and orchestrating chronic inflammation. The focus of this proposal is to delineate a novel pathway that is essential to protect the intestinal epithelium from TNF and determine the relevance of this pathway to IBD.

PI_NAMEs: SONNENBERG, GREGORY F (contact)

PROGRAM_OFFICER_NAME: HUDSPETH, KELLY

PROJECT_TERMS: Address;American;autocrine;Automobile Driving;Biological;Birth;Cell Death;Cell Death Induction;cell motility;Cell Nucleus;Cell Survival;Cells;Cellular biology;Chronic;Chronic Disease;chronic inflammatory disease;Clinical Research;Critical Pathways;curative treatments;cytokine;Cytoplasmic Tail;Data;Dinoprostone;Disease;Epithelial Cells;Epithelium;Equilibrium;Exhibits;Experimental Models;experimental study;Gastrointestinal tract structure;Genes;Growth Factor;gut inflammation;Health;health economics;Hematopoietic;heparin-binding EGF-like growth factor;Homeostasis;Host Defense;Human;Immune;Immunity;Immunology;Inflammation;Inflammatory;Inflammatory Bowel Diseases;interleukin-22;Interleukins;intestinal epithelium;Intestinal Neoplasms;Intestines;Investigation;Knowledge;Lymphocyte;Lymphoid Cell;Mediating;microbial;Modeling;Molecular;mouse model;Mus;Nature;novel;novel therapeutics;Nuclear Export;Nuclear Translocation;Organoids;Outcome;overexpression;Pathogenesis;Pathologic;Pathway interactions;Patients;Predisposition;Production;Prostaglandin Production;Prostaglandin Receptor;Prostaglandins;protective pathway;Proteolytic Processing;Publishing;receptor;Regulation;response;Role;Sampling;Shapes;Signal Transduction;single-cell RNA sequencing;socioeconomics;Source;Testing;Therapeutic;tissue regeneration;Tissues;TNF gene;Translating;translational study;treatment strategy;ZNF145 gene

PROJECT_TITLE: Novel mechanisms protecting the gut from TNF

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-KUDS-P(03)]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric

ORG_CITY: DAVIS

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: PROJECT NARRATIVE This study tests the effectiveness of the Early Start Denver Model (ESDM) in community agencies that serve young autistic children. The feasibility, usability and acceptability of the model will be explored. Understanding effectiveness of new evidence-based models will increase the quality of autism care available to more diverse children and families in more geographic locations.

PI_NAMEs: STAHMER, AUBYN C. (contact)

PROGRAM_OFFICER_NAME: PUGLIESE, CARA ELISABETH

PROJECT_TERMS: Acceleration;acceptability and feasibility;Adaptive Behaviors;Address;Affect;applied behavior analysis;autism community;autism spectrum disorder;autism symptoms;autistic;autistic children;Behavior Therapy;caregiver education;Caregivers;Caring;Child;Child Rearing;Clinical effectiveness;Clinical Trials;Communities;Community Practice;community setting;Community Trial;Competence;cost;Data;Data Collection;Development;Drug Prescriptions;Education;effective intervention;Effectiveness;effectiveness evaluation;Effectiveness of Interventions;effectiveness testing;effectiveness/implementation design;efficacy study;efficacy testing;efficacy trial;Ensure;Environment;ethnic diversity;Ethnic Origin;evidence base;Family;Funding;Geographic Locations;Goals;Growth;health goals;Hybrids;implementation barriers;implementation determinants;implementation outcomes;Improve Access;improved;Insurance;Intervention;Language;language outcome;Learning;Learning Skill;Manuals;Measures;Mediating;Meta-Analysis;Methods;Modeling;Motivation;Outcome;Parents;Participant;Pilot Projects;programs;Provider;provider adherence;Public Health;Quality of Care;Race;randomized controlled design;Randomized, Controlled Trials;Regulation;Research;Sampling;satisfaction;scale up;Science;secondary outcome;service delivery;Services;social;social communication;social engagement;social learning;Structure;System;systematic review;Testing;theories;Time;Training;treatment as usual;treatment effect;treatment group;usability

PROJECT_TITLE: Examining the Effectiveness of the Early Start Denver Model in Community Programs serving Young Autistic Children

STUDY_SECTION: EMHI

STUDY_SECTION_NAME: Effectiveness of Mental Health Interventions Study Section[EMHI]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Pediatric

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Project Narrative There is a paucity of data to inform safe and effective prescribing practices in children. Real-world evidence (RWE) studies using data from routine clinical practice have the potential to generate high-quality evidence that could guide prescribing when randomized controlled trials do not but are underdeveloped in pediatrics. This study aims to develop a rigorous framework for RWE studies such that they can reliably address key evidence gaps of medication safety and effectiveness in pediatrics.

PI_NAMEs: SAVAGE, TIMOTHY JOHN (contact)

PROGRAM_OFFICER_NAME: FABIYI, CAMILLE

PROJECT_TERMS: Address;Adult;Advisory Committees;Age;age group;Agreement;Area;Calibration;Categories;Cellulitis;Cephalexin;Child;Childhood;Clinical;clinical care;Clinical Data;clinical practice;Clinical Trials;comparative effectiveness;comparative safety;Complement;Controlled Study;Data;Data Files;Data Reporting;Data Set;Data Sources;Databases;design;Development;Diagnostic;Disease;Drug Prescriptions;Effectiveness;Electronic Health Record;Epidemiologic Methods;Evaluation;Event;Exposure to;FDA approved;Foundations;Generations;Goals;health care service utilization;Healthcare;Hospitals;improved;Infant;Insulin-Dependent Diabetes Mellitus;Knowledge;Label;Machine Learning;Measures;Medical;medication safety;Mentors;Mentorship;Methodology;Methods;Modeling;National Institute of Child Health and Human Development;novel;novel therapeutics;off-label use;Omeprazole;Outpatients;Patient Care;Patients;pediatric patients;Pediatric Research;Pediatrics;Pharmaceutical Economics;Pharmaceutical Preparations;Pharmacoepidemiology;Pharmacology;Population;Process;prospective;Protocols documentation;Public Health Schools;Publishing;Quality of Care;Randomized, Controlled Trials;Ranitidine;Reproducibility;Research;Research Design;Research Personnel;Research Priority;Risk;Safety;safety assessment;scaffold;Series;Source;success;Therapeutic Uses;Training;Trimethoprim-Sulfamethoxazole;venous thromboembolism;Visit;Warfarin;Woman;Work

PROJECT_TITLE: The development of a systematic approach to harness real-world evidence for the evaluation of medication safety and effectiveness in children

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Pediatrics Study Section[CHHD-A]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Genetics;Health Services;Lung;Lung Cancer;Prevention;Tobacco;Tobacco Smoke and Health

ORG_CITY: IOWA CITY

ORG_NAME: BD HOLDING, INC.

ORG_STATE: IA

PHR: Narrative The purpose of this application is to complete development of a DNA methylation test can help determine whether a smoker should undergo low dose CT screening for Lung Cancer and if this methylation test can help predict risk for cancer.

PI_NAMEs: DAWES, KELSEY ;PHILIBERT, ROBERT A (contact)

PROGRAM_OFFICER_NAME: FRANCA-KOH, JONATHAN C

PROJECT_TERMS: Advisory Committees;Age;age effect;Algorithms;Area Under Curve;arm;Aryl Hydrocarbon Receptor;base;Behavioral;Biological Assay;Biological Sciences;biomarker development;biomarker identification;Biopsy;cancer risk;Cigarette;Clinic;Clinical;Collection;Colon;Colon Carcinoma;commercialization;Consumption;cost;Counseling;Data;demethylation;Detection;Development;Diagnostic;digital;DNA;DNA Methylation;Dose;Educational Status;effective therapy;Eligibility Determination;Epigenetic Process;Gender;Genes;Health Care Costs;high risk;improved;innovation;Intellectual Property;International;Investments;Laboratories;low dose computed tomography;Lung;lung cancer screening;Malignant neoplasm of lung;Malignant neoplasm of ovary;Malignant neoplasm of prostate;Manufacturer;Marketing;Methods;Methylation;methylation testing;Monitor;Morbidity - disease rate;mortality;Ovarian;Participant;Patients;Peer Review;Persons;Phase;Preventive service;Production;Property Rights;Prostate;Publications;Publishing;Race;Radiation;Radiation exposure;Reagent;Receiver Operating Characteristics;Recommendation;Recording of previous events;Reporting;Research;response;Risk;risk prediction;Roentgen Rays;Running;Saliva;screening;Site;Smoke;Smoker;Smoking;smoking cessation;Smoking History;Smoking Status;Specimen;success;Telemedicine;Testing;tool;Unnecessary Procedures;Update;Work;X-Ray Computed Tomography

PROJECT_TITLE: An Improved Epigenetic Algorithm for Guiding Low Dose CT Lung Cancer Screening

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HSS-J(10)B]


ADMINISTERING_IC: GM

ED_INST_TYPE: GRADUATE SCHOOLS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: PHILADELPHIA

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: DREXEL UNIVERSITY

ORG_STATE: PA

PHR: NARRATIVE Inflammation is a pervasive driver of disease progression and a crucial mediator of tissue healing processes. This proposal will develop biomaterials that improve our understanding of interactions between different immune system components and recapitulate the progression of signaling mechanisms that underlie normal tissue healing. The work will have broad implications for the development of drug delivery systems and synergistic therapies to treat disease and promote tissue healing.

PI_NAMEs: RODELL, CHRISTOPHER B (contact)

PROGRAM_OFFICER_NAME: CHAO, CHIEN-CHUNG

PROJECT_TERMS: adaptive immune response;Area;Atherosclerosis;Biocompatible Materials;Body System;Bone Marrow;cell motility;cell type;Cells;chemokine;chronic inflammatory disease;Cicatrix;Communication;cytokine;design;Disease;Disease Progression;Distant;Drug Delivery Systems;drug development;Evolution;experience;first responder;Generations;healing;Heart failure;Hydrogels;Immune;immune modulating agents;Immune response;Immune system;immunoregulation;improved;Inflammation;Inflammatory;Inflammatory Response;Injectable;Injury;Injury to Kidney;Innate Immune System;Intestines;Investigation;ischemic injury;kidney fibrosis;local drug delivery;Macrophage;Mediator;Medicine;monocyte;Myocardial Infarction;Natural regeneration;Normal tissue morphology;Organ;Outcome;Pharmaceutical Preparations;Phenotype;Process;Pulmonary Fibrosis;recruit;regenerative;Regulatory T-Lymphocyte;Research;response;response to injury;Rheumatoid Arthritis;Signal Transduction;Site;Source;synergism;systemic inflammatory response;targeted delivery;targeted treatment;Therapeutic;tissue injury;Tissues;tumor-immune system interactions;Work

PROJECT_TITLE: Designing supramolecular delivery strategies to understand and exploit synergies in immunoregenerative medicine


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Hepatitis;Liver Disease;Organ Transplantation;Substance Misuse;Transplantation

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: NARRATIVE Alcohol-related liver disease (ALD), from chronic cirrhosis to acute alcoholic hepatitis, is now the leading indication for liver transplantation in the United States. However, there is no consensus on the optimal transplant candidate selection criteria, and center-specific practices remain the norm. This project will 1) study the impacts of liver transplant and sobriety on survival in alcoholic hepatitis and 2) identify the ideal predictors of post-transplant outcomes in ALD. The study findings will help establish standardized and transparent liver transplant candidate selection in ALD across the United States.

PI_NAMEs: CHEN, PO-HUNG (VICTOR)  (contact)

PROGRAM_OFFICER_NAME: GAO, PETER

PROJECT_TERMS: Abstinence;Acute;Acute Alcoholic Hepatitis;addiction;Adrenal Cortex Hormones;adverse outcome;alcohol abstinence;alcohol abuse therapy;Alcohol consumption;alcohol relapse;alcohol research;alcohol screening;Alcoholic Hepatitis;Alcoholic Liver Diseases;Alcohols;Attenuated;Behavioral;Biological Markers;Biometry;candidate selection;career development;Cessation of life;Chronic;Cirrhosis;Clinical Investigator;cohort;Cohort Studies;Collaborations;Communities;Consensus;Country;Data;Decision Making;Delphi Technique;Development;Development Plans;Electronics;empowerment;Europe;Evaluation;Event;evidence base;experience;follow-up;Fostering;Funding;Future;Goals;Graft Rejection;Hepatitis C;Hepatology;improved;Inferior;Injury;interdisciplinary approach;Intervention;Interview;Knowledge;Liver diseases;liver transplantation;Medical;Medicine;member;mortality;mortality risk;Multicenter Trials;National Institute on Alcohol Abuse and Alcoholism;Natural History;non-alcoholic fatty liver disease;novel;Outcome;Patients;Pilot Projects;post-transplant;Predictive Analytics;predictive modeling;Process;Program Development;prolonged abstinence;Protocols documentation;Questionnaires;Refractory;Relapse;relapse risk;Reproducibility;Research;Research Personnel;Research Training;Risk Estimate;risk prediction;Science;Scientist;Selection Criteria;skills;sobriety;Social support;Standardization;substance use;supportive environment;Surveys;tool;transplant centers;Transplant Recipients;Transplantation;United States;Universities;Validation;Work

PROJECT_TITLE: Candidate Selection for Liver Transplantation in Patients with Alcohol-related Liver Disease

STUDY_SECTION: AA

STUDY_SECTION_NAME: Biomedical Research Study Section[AA(AA)-1]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Infectious Diseases;Microbiome

ORG_CITY: FARMINGTON

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT

ORG_STATE: CT

PHR: PROJECT NARRATIVE Oral thrush continues to be a clinically significant problem for patients with weak immune systems. The proposed studies have the potential to lead to a paradigm shift in how clinicians and scientists view the microbiome changes characterizing this infection. This project will identify certain oral bacteria as new, clinically relevant mediators of invasive disease thus providing justification for the combined use of antifungal and anti-bacterial treatments in high risk patients, such as patients undergoing intensive cancer chemotherapy.

PI_NAMEs: DONGARI-BAGTZOGLOU, ANNA I (contact)

PROGRAM_OFFICER_NAME: MCNEALY, TAMARA L

PROJECT_TERMS: Adrenal Cortex Hormones;Anti-Bacterial Agents;anti-fungal agents;Antibiotics;Apoptosis;Bacteria;bacterial community;bacteriome;Biological Markers;Biomass;Blood Circulation;Calpain;Candida;Candida albicans;Candidiasis;chemotherapeutic agent;chemotherapy;Chemotherapy-Oncologic Procedure;Clinical;clinically relevant;clinically significant;commensal microbes;Communities;Complex;Cortisone;Cytotoxic Chemotherapy;Development;Disease;disease model;dysbiosis;E-Cadherin;Ecosystem;Enterococcus;Enterococcus faecalis;Environment;Epithelial Cells;Exhibits;Fluorouracil;Funding;Fungemia;fungus;Gene Expression;Genes;Genetic Transcription;Goals;Grant;Growth;high risk;high risk population;Human;Hyphae;Immune response;Immune system;Immunocompetent;Immunocompromised Host;immunological status;immunopathology;Immunosuppression;Indigenous;Infection;infection risk;Inflammation;Invaded;Malignant Neoplasms;Mediator;microbial;Microbial Biofilms;microbiome;microbiota;Modeling;Modification;mouse model;mucosal biofilms;mucosal microbiota;Mucous Membrane;Mus;Mycoses;Neutropenia;neutrophil;novel;Oral;oral bacteria;Oral candidiasis;oral cavity epithelium;oral commensal;oral microbiome;Oral mucous membrane structure;Organism;Oropharyngeal;oropharyngeal thrush;pathobiont;pathogen;Pathogenesis;pathogenic fungus;Pathogenicity;Pathway interactions;Patients;pharmacologic;polymicrobial biofilm;Population Sizes;Probiotics;Refractory;Research;response;Risk;Risk Factors;Role;Scientist;Signal Pathway;Streptococcus;Streptococcus oralis;synergism;Testing;TLR2 gene;Toxic effect;Virulence;virulence gene;Work

PROJECT_TITLE: Oral Epithelial Cells, Candida and PMN Activation

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]


ED_INST_TYPE: UNIVERSITY-WIDE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Mental Health;Neurosciences

ORG_CITY: Boulder

ORG_NAME: UNIVERSITY OF COLORADO

PHR: Project Narrative The nucleus accumbens is a region of the brain involved in maintaining social attachments to partners, the loss of which are detrimental to mental health. Here, I seek to investigate the role of an understudied, but powerful cell type in the nucleus accumbens – the inhibitory interneuron – in the development of social attachments. This proposal will expand our fundamental understanding of how the brain forms and maintains social attachments, thus paving the way for possible therapies for deficits in social bonding.

PI_NAMEs: EL-KALLINY, MOSTAFA  (contact)

PROGRAM_OFFICER_NAME: VAN'T VEER, ASHLEE VICTORIA

PROJECT_TERMS: Acute;Brain;Brain region;Calcium;career;cell type;Cells;Childhood;Clinical;Data;designer receptors exclusively activated by designer drugs;Deterioration;Development;Disease;Dissection;Exhibits;experimental study;Future;Goals;Health;Heart;Human;Image;in vivo imaging;Individual;Induced Neurons;Influentials;insight;Interneurons;Investigation;Knowledge;Laboratories;Laboratory mice;Laboratory Rat;Mediating;Mental disorders;Mental Health;Methods;Microtus;neural;neural circuit;Neurologist;Neurology;neuromechanism;Neurons;Neurosciences;neurotransmission;novel;novel therapeutics;Nucleus Accumbens;Pair Bond;physical conditioning;Physicians;Population;prairie vole;preference;psychologic;Risk;Role;sensor;Series;Signal Transduction;social;social attachment;social deficits;Social Development;Social Interaction;Source;Study models;Testing;Training;Translating;Viral;Work

PROJECT_TITLE: Interrogating the role of inhibitory interneurons of the nucleus accumbens in social attachment


ADMINISTERING_IC: AG

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Physical Activity;Prevention

ORG_CITY: BLACKSBURG

ORG_DEPT: NUTRITION

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

ORG_STATE: VA

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it will advance mechanistic understanding of exercise adaptation in skeletal muscle of a relevant AD mouse model and the roles of a key regulator of cellular energetics in AD etiology, a pathology for which there are few treatment options. The project is relevant to NIA’s mission because it focuses on the molecular and physiological response of skeletal muscle mitochondria in the context of AD neuropathology that indicates a maladaptive bioenergetic response to exercise, which may elucidate an integrated mechanism that will take into account the system-dependent nuance of bioenergetic dysregulation in AD etiology.

PI_NAMEs: DRAKE, JOSH C (contact)

PROGRAM_OFFICER_NAME: BOYCE, AMANDA T

PROJECT_TERMS: 5'-AMP-activated protein kinase;Acute;Address;Age;Age Months;age related;Alzheimer like pathology;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;APP-PS1;Bioenergetics;Biogenesis;Biological Models;Brain;Cognitive;Confocal Microscopy;Data;Defect;Development;Diagnosis;disease phenotype;endurance exercise;Etiology;Exercise;exercise training;Experimental Designs;Female;Functional disorder;gain of function;Goals;Health;Hippocampus;Histocytochemistry;Human;Impaired cognition;Impairment;improved;in vivo;innovation;insight;Intervention;Intramuscular;Knock-in Mouse;Knockout Mice;Label;loss of function;male;Metabolic;metabolomics;mild cognitive impairment;Mission;Mitochondria;Molecular;Motor Neurons;mouse model;Mus;Muscle;Muscle Fibers;muscle form;Muscle function;Muscle Mitochondria;Muscular Atrophy;Neuromuscular Junction;Neurons;neuropathology;neurophysiology;new therapeutic target;novel;Pathology;Peripheral;Phase;Physiological;Plasma;pre-clinical;prevent;Production;Protein Isoforms;proteostasis;Public Health;Reactive Oxygen Species;Reporting;Research;Respiration;response;Role;Running;sedentary;sensor;Signal Transduction;Skeletal Muscle;stoichiometry;Symptoms;System;systems research;Testing;Therapeutic;therapeutic development;Tissues;Transgenic Mice

PROJECT_TITLE: Exercise and muscle mitochondria in Alzheimer's Disease

STUDY_SECTION: SMEP

STUDY_SECTION_NAME: Skeletal Muscle and Exercise Physiology Study Section[SMEP]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cocaine;Drug Abuse (NIDA only);Neurosciences;Prevention;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: INDIANAPOLIS

ORG_DEPT: PHARMACOLOGY

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: PROJECT NARRATIVE Hyperexcitable cortical pyramidal neurons (CPNs) in motor cortex, specifically the supplementary motor cortex (M2) may cause relapse, the most challenging stage in the clinical treatment of substance use disorder. We will try to attenuate the hyperexcitability of M2 CPNs in the M2 area, and to depress the axonal terminal transmission of the CPNs to the dorsolateral striatum. Our hope is to identify novel molecular, neuronal and circuitry targets to prevent relapse to drugs.

PI_NAMEs: MA, YAO-YING  (contact)

PROGRAM_OFFICER_NAME: TSAI, SHANG-YI ANNE

PROJECT_TERMS: Abstinence;addiction;Anterior;Area;Attenuated;Awareness;Behavior;Brain;Cells;Chronic;cingulate cortex;Clinical;Clinical Management;Clinical Research;Clinical Treatment;Cocaine;Cocaine Dependence;cocaine exposure;cocaine seeking;cocaine self-administration;Conscious;Corpus striatum structure;craving;Data;Dorsal;drug craving;drug relapse;drug seeking behavior;Genetic;Glutamates;Habits;hippocampal pyramidal neuron;Image;Impulsivity;in vivo;indium arsenide;Infusion procedures;Injections;Intravenous;knock-down;Laboratory Animal Models;Lead;Measures;Medial;Mediating;Membrane;Molecular;Motivation;Motor;Motor Cortex;neuronal excitability;Neurons;neurotransmitter release;novel;Nucleus Accumbens;Optics;optogenetics;patch clamp;Pathway interactions;Patient Self-Report;Pharmaceutical Preparations;pharmacologic;postsynaptic;Prefrontal Cortex;Presynaptic Terminals;prevent;programs;Proteins;Protocols documentation;psychostimulant;Rattus;Recording of previous events;Relapse;relapse prevention;relapse risk;Rewards;risk prediction;Ritual compulsion;Saline;Self Administration;Sprague-Dawley Rats;substance use;Substance Use Disorder;Synapses;Synaptic Transmission;Testing;Thinking;transmission process;voltage;Western Blotting;Withdrawal

PROJECT_TITLE: Involvement of Cortical Excitatory Projections in Cocaine Addiction

STUDY_SECTION: PMDA

STUDY_SECTION_NAME: Pathophysiological Basis of Mental Disorders and Addictions Study Section[PMDA]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Bipolar Disorder;Brain Disorders;Clinical Research;Depression;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Pediatric;Prevention;Serious Mental Illness

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: RELEVANCE (See instructions): Bipolar Disorder (BD) is often misdiagnosed as Major Depressive Disorder (MDD). The proposed MERIT  extension aims to study a new sample of young adults at familial risk of BD and/or MDD using more  sensitive measures of brain activity and repeated brain scans, to test present findings, identify robust brain  markers of BD vs. MDD risk, improve early BD risk identification, and aid new treatment development.

PI_NAMEs: PHILLIPS, MARY LOUISE (contact)

PROGRAM_OFFICER_NAME: WIJTENBURG, SARAH ANDREA

PROJECT_TERMS: Accounting;Adopted;Affective Symptoms;Age;Amygdaloid structure;Anger;Anhedonia;Anisotropy;Anxiety;Award;Behavior;Bilateral;Bipolar Disorder;Brain;Brain scan;circadian;Clinical;Clinical assessments;Corpus striatum structure;Data;Decision Making;depressive symptoms;Diagnostic;Dimensions;discounting;Disease;disorder risk;Dopamine;Electroencephalography;emotion dysregulation;emotion regulation;Esthesia;Family history of;Feeling suicidal;Fiber;follow-up;Functional Magnetic Resonance Imaging;Future;Gender;Goals;graph theory;high risk;Hostility;hypomania;improved;Impulsivity;Individual;Inferior;Instruction;Intervention;Left;Major Depressive Disorder;Manic;Measures;Mediating;Mental Depression;Mental disorders;Mental Health;Methods;Midbrain structure;multimodality;neural;neural network;neuroimaging;neuromechanism;neuromelanin;Noise;novel;Parents;Participant;Pathway interactions;Personality Disorders;Personality Traits;predictive marker;Prefrontal Cortex;prevent;Process;prospective;Quality of life;Recording of previous events;Resolution;response;reward expectancy;Rewards;Risk;Sampling;Severities;source localization;Symptoms;Temporal Lobe;temporal measurement;Testing;therapy development;Thick;transmission process;Trauma;white matter;Work;young adult

PROJECT_TITLE: Reward, impulsive sensation seeking and emotional dysregulation: neural mechanisms underlying risk for bipolar disorder in young adults

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ORG_CITY: East Greenwich

ORG_NAME: GORDON RESEARCH CONFERENCES

ORG_STATE: RI

PHR: PROJECT NARRATIVE: The Gordon Research Conference and the Gordon Research Seminar on Chemotactic Cytokines will bring together scientists from all over the world from an unusually diverse array of scientific disciplines and experimental approaches to discuss the functions of chemokines in health and disease ranging from inflammatory diseases to cancer, neurological disorders and autoimmunity. It will pave the way for the identification of new therapeutic targets for drug development by fostering the exchange of information between basic scientists, clinicians and researchers from the biomed industry. The meeting will promote direct informal exchange of ideas coming from different scientific disciplines, countries, as well as ethnic, experience and gender groups, and facilitate the training of the next generation scientists in this exciting multidisciplinary research field.

PI_NAMEs: ALON, RONEN  (contact)

PROGRAM_OFFICER_NAME: BARTELS, ADELINA EWURA-ABENA

PROJECT_TERMS: Area;Atmosphere;Attention;Autoimmune Diseases;Autoimmunity;Basic Science;Biochemistry;Cancer Biology;Cell Communication;cell motility;Cells;Cellular biology;chemokine;Chemotactic Factors;Clinical;clinically relevant;Communicable Diseases;Complement;Complex;Country;Data;Dedications;Degenerative Disorder;design;Development;Developmental Biology;disabled;Discipline;Disease;drug development;Drug Industry;Ethnic Origin;Europe;Event;experience;Exposure to;Family;Feedback;Fees;Female;Fostering;Friends;Funding;Future Generations;G-Protein-Coupled Receptors;Gender;graduate student;GTP-Binding Proteins;Health;Homeostasis;Human Pathology;Imaging Device;Immune;Immunity;Immunologic Surveillance;Immunology;Immunotherapy;improved;Industry;Infection;Inflammation;Inflammatory;Interdisciplinary Study;interest;International;Jaw;lecturer;lectures;Leisure Activities;Leukocyte Trafficking;Ligands;Malignant Neoplasms;Mediating;meetings;Mentors;Minority Participation;Molecular;multidisciplinary;Nervous System Disorder;Neurobiology;neuroinflammation;neuron development;Neurons;new therapeutic target;next generation;novel;Oral;Participant;Pathology;peer;Pharmaceutical Preparations;Physiological Processes;Positioning Attribute;Postdoctoral Fellow;posters;Process;Productivity;programs;Proteins;Publishing;receptor;Regulation;Request for Applications;Research;Research Personnel;Research Project Grants;Scientist;Senior Scientist;Series;Social Interaction;Specialist;Stromal Cells;structural biology;Students;symposium;System;Techniques;Therapeutic;Tissues;tool;Training;training opportunity;translational potential;treatment strategy;tumor;United States National Institutes of Health;Vertebrates;Work;wound healing

PROJECT_TITLE: 2024 Chemotactic Cytokines Gordon Research Conference and Gordon Research Seminar

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 LK-D (J1)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Burden of Illness;Caregiving Research;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurodegenerative;Palliative Care;Rural Health;Social Determinants of Health

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PUBLIC HEALTH SIGNIFICANCE This 5-year multilevel longitudinal study investigates informal caregivers' (unpaid family members and friends) involvement in end-of-life care of residents with advanced dementia in 45 diverse assisted living communities in Georgia. Our goal is to improve understanding of the relationships between and among informal caregiver involvement, informal caregiver health, and quality of life of assisted living residents with advanced dementia at end of life and ultimately identify potentially modifiable factors at the individual, assisted living, and wider community-level associated with adverse outcomes. This study, which is the first to focus on these relationships in depth or over time, will offer valuable insights to researchers, policymakers, and providers.

PI_NAMEs: PERKINS, MOLLY M (contact)

PROGRAM_OFFICER_NAME: GERALD, MELISSA S

PROJECT_TERMS: Activities of Daily Living;Address;advanced dementia;adverse outcome;Affect;Age;Alzheimer's Disease;Alzheimer's disease related dementia;American;Assisted Living Facilities;Awareness;care burden;Care given by nurses;care providers;care recipients;Caregiver Burden;Caregivers;caregiving;Caring;Characteristics;Communities;community living;community-level factor;Complex;County;Dementia;dementia care;depressive symptoms;Diagnosis;Distress;Emotional;end of life;end of life care;experience;Face;Family;Family member;Frequencies;Friends;Future;Goals;Health;Healthcare;hospice environment;hospice utilization;Hour;improved;Individual;informal care;informal caregiver;insight;Intervention Trial;Investigation;Knowledge;Long-Term Care;Longitudinal Studies;Managed Care;Mediating;Medical;Mental Health;Mission;Monitor;Nature;nursing skill;older adult;Outcome;Perception;Persons;physical conditioning;Play;Policies;Policy Maker;Population;Privatization;prospective;Provider;Public Health;Quality of life;Recommendation;Research;Research Personnel;Resources;response;Role;Rural;rural area;Sampling;Science;social;social model;Socioeconomic Status;Spirituality;Stress;Taxes;Time;Training;Training and Education;trial design;urban area;Visit

PROJECT_TITLE: Investigating Informal Caregivers' Involvement in End-of-Life Care among Assisted Living Residents with Advanced Dementia and its Influence on Resident and Caregiver Outcomes

STUDY_SECTION: CMPC

STUDY_SECTION_NAME: Clinical Management of Patients in Community-based Settings Study Section[CMPC]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences;Prevention;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: This research study will investigate the mechanisms by which microglia dysfunction due to age and inheritance of genetic risk factors contribute to Alzheimer Disease, a devastating neurodegenerative condition that impairs memory and causes cognitive and psychiatric deficits. Because microglia play important roles in maintaining brain homeostasis and health, therapies aimed at restoring or enhancing their normal function may effectively mitigate disease course. This proposal aims to validate the role of the AD protective CD33 allele and elucidate the mechanism by which it regulates microglia homeostasis and can be targeted as novel AD therapeutic.

PI_NAMEs: POON, WAYNE W (contact)

PROGRAM_OFFICER_NAME: SARE, RACHEL

PROJECT_TERMS: Age;age related;Alleles;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease risk;Alzheimer's disease therapeutic;Alzheimer's disease therapy;Amyloid;Antibodies;B-Lymphocytes;Behavior;Binding;Biological Assay;Brain;Cell Reprogramming;Cells;Cognition;Cognitive;Dementia;Development;Disease;disorder risk;Endocytosis;Environment;Etiology;exon skipping;Exons;experimental study;extracellular;Family;Functional disorder;Gene Family;Genes;Genetic Diseases;Genetic Polymorphism;Genetic Risk;genetic risk factor;genome wide association study;Genotype;Goals;Health;Homeostasis;Human;Human Genetics;Immunoglobulins;improved;in vivo;induced pluripotent stem cell;innovation;Interferons;Investigation;ITAM;ITIM;Late Onset Alzheimer Disease;Lectin;Ligand Binding;Ligands;Linkage Disequilibrium;Liposomes;member;Membrane Proteins;Memory impairment;Metabolism;Microglia;Molecular Profiling;mouse model;Mus;nanoparticle;Nerve Degeneration;Neurofibrillary Tangles;neuroinflammation;Neurons;neurotransmission;novel;Orthologous Gene;Pathology;Patients;Phagocytosis;Phenotype;Play;PLCG2 gene;Population;programs;protein expression;Protein Isoforms;protein protein interaction;Proteins;receptor;Recycling;Regulation;research study;response;Risk;Role;sialic acid binding Ig-like lectin;Sialic Acids;Signal Transduction;Single Nucleotide Polymorphism;Synapses;Testing;tool;transcriptome;transcriptome sequencing;Transgenic Mice;Transgenic Organisms;transmission process;TREM2 gene;TYROBP gene;Xenograft procedure

PROJECT_TITLE: Cell autonomous and non-cell autonomous phenotypes due to genetic risk for late onset Alzheimers disease


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

PHR: PROJECT NARRATIVE Neurodegenerative diseases, like Alzheimer's, have massive accumulation of proteins such as tau, which is linked to the failure of the cellular recycling system known as autophagy. A unique protein called BOK connects an intricate signaling network between autophagy and cellular survival. This project will elucidate the metabolic pathways regulated by BOK in order to reveal potential mechanisms by which to prevent tau-mediated death of neurons.

PI_NAMEs: KATZ, SAMUEL G (contact)

PROGRAM_OFFICER_NAME: BARRETT, PAUL JOHN

PROJECT_TERMS: Ablation;Address;aged;Agreement;Alzheimer's Disease;Alzheimer's disease related dementia;Apoptosis;Apoptotic;Autophagocytosis;Autophagosome;BCL1 Oncogene;Binding;Biochemical;Brain;Calcium;Calcium Signaling;Cell Death;Cell Death Induction;Cell Membrane Permeability;Cell Physiology;Cell Survival;Cells;Chemicals;Chloroquine;Clinical Trials;Cytoprotection;Data;Dementia;Diagnosis;Disease;Dose;Endoplasmic Reticulum;endoplasmic reticulum stress;Equilibrium;Exhibits;Failure;Family member;Fibroblasts;Genes;Goals;Homeostasis;Impairment;In Vitro;in vivo;Individual;Induction of Apoptosis;inhibition of autophagy;inhibitor;innovation;inositol 3-phosphate;Intervention;intravital microscopy;Ions;ITPR1 gene;Lasers;Link;MAPT gene;Measures;Mediating;Membrane;Metabolic;Metabolic Pathway;Metabolism;Mitochondria;Molecular;Morphology;Motor;Mus;Nerve Degeneration;Neurodegenerative Disorders;Neurofibrillary Tangles;neuron loss;Neurons;next generation;novel;Null Lymphocytes;Outer Mitochondrial Membrane;Ovarian;Pathologic;Pathway interactions;Patients;Physiologic pulse;Physiological;Play;prevent;Principal Investigator;Production;programs;Proteins;proteotoxicity;Recycling;Regulation;Research;Research Personnel;Research Project Grants;resilience;Resistance;response;Role;Signal Pathway;Signal Transduction;Site;Stimulus;Stress;Structure;System;targeted treatment;tau aggregation;tau mutation;tau Proteins;Tauopathies;Techniques;Thapsigargin;Therapeutic;therapeutic development;therapeutic target;Tremor;two-photon;Up-Regulation;Uridine;Vacuole;Vesicle;Work

PROJECT_TITLE: Contribution of Mitochondrial Associated Membrane (MAM) Signaling to Neurodegeneration

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cardiovascular;Cerebrovascular;Dementia;Genetics;Heart Disease;Neurodegenerative;Neurosciences;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: NARRATIVE Ageing and cerebrovascular disorders are known to lead to white matter abnormalities and cognitive impairment. The studies described in this proposal are designed to gain a better understanding of the molecular and cellular pathogenesis that underlies the dementia that develops in these individuals. Our working hypothesis is that strategies that increase oligodendrocyte protection against the cytotoxic CNS environment that develops in response to ageing and cerebrovascular maladies will help ameliorate the white matter and cognitive abnormalities that develop.

PI_NAMEs: FLANAGAN, MARGARET E;POPKO, BRIAN J (contact)

PROGRAM_OFFICER_NAME: NEWMAN, ELIZABETH

PROJECT_TERMS: Adult;Age;Aging;aging process;aging related;Alleles;Alzheimer's Disease;animal old age;Animals;Autopsy;Behavioral;Behavioral Assay;biological adaptation to stress;Biological Assay;Blood flow;Brain;brain health;Cardiovascular Abnormalities;Cardiovascular Diseases;Cardiovascular system;Cell Lineage;cell type;Cells;Cellular Stress;central nervous system vasculature;cerebrovascular;Cerebrovascular Circulation;Cerebrovascular Disorders;Cerebrovascular system;clinically relevant;Cognition;Cognition Disorders;Cognitive;comorbidity;Cytoprotection;cytotoxic;Dementia;dementia risk;design;Development;Diffuse;EFRAC;Elderly;Environment;Eukaryotic Cell;extracellular;Functional disorder;Genes;genetic approach;Genetic Transcription;Gliosis;Goals;Health;Heart failure;High Fat Diet;Human;Hypertension;Hypoxia;hypoxia inducible factor 1;Impaired cognition;Impairment;Incidence;Individual;Inflammation;juvenile animal;Lead;Lesion;Link;Maintenance;Memory;Metabolic;Metabolic syndrome;Molecular;mouse model;Mus;Mutant Strains Mice;Mutation;Myelin;Nerve Degeneration;Neuroglia;Neurologic;Neurology;Neurons;neuropathology;neuroprotection;Nitric Oxide Synthase;normal aging;nuclear factor-erythroid 2;Nutrient;nutrient deprivation;Obesity;old mice;oligodendrocyte lineage;Oligodendroglia;Oxidative Stress;Oxygen;Pathogenesis;Pathologic;Pathway interactions;Persons;pharmacologic;Play;Positioning Attribute;preservation;Reporting;response;Risk;Role;Sampling;Series;sex;Stimulus;Stress;Tamoxifen;Therapeutic;therapeutically effective;Time;Universities;Vascular blood supply;Vascular Dementia;white matter;White Matter Disease;World Health Organization;young adult

PROJECT_TITLE: Exploring the origins of myelin abnormalities in normal ageing and in vascular dementia

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Narrative Alzheimer’s disease (AD), the most common neurodegenerative disorder, afflicts millions of individuals worldwide. Unless highly effective disease modifying therapies are identified, the AD epidemic will continue to exact an ever-expanding and profound personal, societal and economic toll. We are exploring a large number of biologically active proteins that co- accumulate with amyloid in the disease, these may play biological roles and could be future targets for therapy.

PI_NAMEs: GOLDE, TODD E;LEVITES, YONA R;PROKOP, STEFAN  (contact)

PROGRAM_OFFICER_NAME: LI, TONG

PROJECT_TERMS: abeta accumulation;abeta deposition;Accounting;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease therapy;Amyloid;Amyloid beta-Protein;Amyloid deposition;Amyloidosis;Apolipoprotein E;Binding;Biological;Biology;Brain;Clinical;Complex;Data;Deposition;design;Development;digital;Disease;Economics;Epidemic;Future;Gliosis;Heparan Sulfate Proteoglycan;Heparitin Sulfate;Human;in vivo;Individual;Infrastructure;insight;Laboratories;Link;Literature;Mainstreaming;Mediating;Methods;midkine;Modeling;mouse model;multiple omics;Nerve Degeneration;Neurites;Neurodegenerative Disorders;Neurons;neurotoxic;neurotoxicity;new therapeutic target;novel;Paper;Pathogenesis;Pathologic;Pathology;Phase;Play;pleiotrophin;Property;Proteins;Proteomics;Publishing;Recombinant adeno-associated virus (rAAV);Reporting;Resources;response;Rodent;Role;Senile Plaques;Signal Transduction;Solubility;spatiotemporal;sulfated glycoprotein 2;System;targeted treatment;tau Proteins;Tauopathies;Therapeutic;Toxin;Validation

PROJECT_TITLE: Amyloidosis associated proteins in Alzheimer’s disease pathogenesis


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Prevention

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Narrative The proposed research is relevant to public health because the proposed study of understanding CSF clearance system in aging human brain is expected to obtain highly-desired knowledge and ultimately help deign effective interventions to Alzheimer's disease. Thus, the proposed research is relevant to the part of NIH's mission that pertains to developing fundamental knowledge and/or novel technologies that will help reduce the burdens of diseases.

PI_NAMEs: QIAN, YONGXIAN  (contact)

PROJECT_TERMS: Abeta clearance;abeta deposition;Adult;Affect;Age;age group;age related changes;Aging;aging brain;aging population;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease risk;Amyloid beta-Protein;arachnoid villi;awake;Blood Vessels;Brain;brain parenchyma;burden of illness;calcification;Cerebrospinal Fluid;cerebrospinal fluid clearance;cerebrospinal fluid flow;clinical diagnosis;Data;Dementia;Deposition;design;Development;Drainage procedure;Early Diagnosis;effective intervention;Electroencephalography;Extracellular Space;Female;glymphatic system;Goals;Health Care Costs;Human;Impairment;Individual;insight;Knowledge;Magnetic Resonance Imaging;male;Metabolic;middle age;Mission;Monitor;Mus;new technology;normal aging;older patient;Older Population;Pathway interactions;Probability;Production;Proteins;Protons;Public Health;Research;Resistance;Resolution;Risk Factors;Senile Plaques;sex;Sleep;Sodium;Structure;Structure of choroid plexus;Study Subject;System;Techniques;Testing;Time;United States;United States National Institutes of Health;Variant;Visualization;wasting;Work

PROJECT_TITLE: Understanding CSF Clearance in Aging and Alzheimerâs Brain Through Dynamic Sodium MRI - Resubmission - 1


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Physical Activity;Prevention

ORG_CITY: COLUMBIA

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

ORG_STATE: SC

PHR: Engaging in lifestyle physical activity is a promising preventive strategy for sustaining cognition and thus reducing the risks of developing neuropsychological diseases in older adults. Current literature has predominately focused on the total volume of physical activity performed but has not yet established the time- sensitive association between daily lifestyle physical activity distribution and everyday cognition. This study bridges the literature gap by leveraging accelerometers and app-based cognitive measures to identify whether activity distribution represents a meaningful behavioral target that can be engaged in everyday life to sustain brain health among vulnerable older adults.

PI_NAMEs: YANG, CHIH-HSIANG  (contact)

PROGRAM_OFFICER_NAME: HARRELL, ERIN

PROJECT_TERMS: Accelerometer;Address;African American;Age;Alzheimer's disease related dementia;Behavioral;brain health;Cognition;Cognitive;cognitive benefits;cognitive function;cognitive testing;Communities;Cross-Sectional Studies;daily functioning;Data;Data Analyses;dementia risk;density;design;Devices;Disease;Distributional Activity;Economic Burden;efficacy trial;eligible participant;evidence base;Exclusion;Exercise;exercise program;Exhibits;Family;Foundations;Frequencies;Funding;Future;Goals;Grain;Health;high risk;Impaired cognition;Incidence;Individual;innovation;Intervention;Knowledge;Life;Life Style;light weight;Link;Literature;Measures;Medical;mobile computing;Modeling;Movement;Neurodegenerative Disorders;Neuropsychology;Not Hispanic or Latino;older adult;Older Population;Pathologic Processes;Pathway interactions;Pattern;Performance;Phase;Physical activity;Population;Posture;pre-clinical;prevent;Prevention;Prevention strategy;Preventive;programs;Race;recruit;Research;Risk;Risk Reduction;Science;smartphone application;Societies;Structure;success;Time;tool;United States National Institutes of Health;Variant;Vulnerable Populations;Walking

PROJECT_TITLE: Temporal Dynamics and Associations of Device-based Activity Distribution Metrics and Everyday Cognition in Older Adults

STUDY_SECTION: LCBH

STUDY_SECTION_NAME: Lifestyle Change and Behavioral Health Study Section[LCBH]


ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: SAINT PAUL

ORG_NAME: MINNESOTA STATE DEPT OF AGRICULTURE

ORG_STATE: MN

PHR: Project Narrative The Minnesota Department of Agriculture seeks to maintain conformance with AFRPS and to incorporate CGMP/PCAF implementation strategies into its regulatory activities, identify and fulfill training needs and auditing programs to advance inspections under the Food Safety Modernization Act (FSMA), build infrastructure and program improvement based upon the PCAF rule, maintain regulatory authorities equivalent to 21 CFR Part 507 and FSMA rules, conduct outreach to promote compliance with FSMA regulations, and participate in joint workplanning, enforcement, and information sharing to support an Integrated Food Safety System.

PI_NAMEs: OPSAHL, DAN  (contact)

PROGRAM_OFFICER_NAME: LITTRELL, KEITH

PROJECT_TITLE: Maintaining Minnesota's Conformance with the Animal Feed Regulatory Program Standards and Coordinating Minnesota's Preventive Control Activities


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biotechnology;Brain Disorders;Clinical Research;Dementia;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Prevention;Sleep Research

ORG_CITY: HADLEY

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF MASSACHUSETTS AMHERST

ORG_STATE: MA

PHR: PROJECT NARRATIVE Sleep-based metrics are promising as potential noninvasive biomarkers for the early identification of individuals at risk of Alzheimer’s disease. In this R01 Research Project Grant, we will collect and analyze sleep and activity data from three wearable devices for sleep, heart rate, and activity monitoring along with blood biomarkers for Alzheimer’s disease from elderly Mass General Brigham Biobank participants with elevated genetic susceptibility to Alzheimer’s disease. We will also develop artificial intelligence tools for digital phenotyping and the discovery of novel sleep- and activity-related predictors of Alzheimer’s disease.

PI_NAMEs: DUTTA, JOYITA  (contact);SAXENA, RICHA

PROGRAM_OFFICER_NAME: LUO, YUAN

PROJECT_TERMS: Abeta clearance;Abeta synthesis;Accelerometer;Adopted;Alzheimer disease detection;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease diagnostic;Alzheimer's disease pathology;Alzheimer's disease risk;Alzheimer’s disease biomarker;Amyloid;Apolipoprotein E;Apple watch;Artificial Intelligence;artificial intelligence model;Benchmarking;biobank;Biological Markers;biomarker discovery;Biometry;Blood;Brain imaging;Clinical;Clinical Trials;Cognition;Cognitive;cognitive change;cognitive function;cognitive testing;cohort;Complex;cost;Data;data acquisition;deep learning;Dementia;Development;Devices;Diagnosis;Digital biomarker;digital data;digital health;digital phenotyping;digital technology;digital tool;Disease;early detection biomarkers;Early Diagnosis;Early identification;Elderly;Electroencephalography;Equation;follow-up;Functional disorder;Future;General Population;Genetic;Genetic Predisposition to Disease;Genetic Risk;genetic risk assessment;Genomics;glymphatic clearance;Heart Rate;heart rate variability;high risk;Home;Human;hypocretin;imaging biomarker;Individual;Learning;Link;Liquid substance;Literature;Manuals;Measures;Mediating;Modeling;Monitor;multi-task learning;myelination;myocyte-specific enhancer-binding-factor 2C;National Institute on Aging;Nerve Degeneration;Neurobehavioral Manifestations;Neurology;neuropathology;noninvasive diagnosis;novel;older adult;Oligodendroglia;Participant;Pathway interactions;Phase;Plasma;polygenic risk score;Polysomnography;Population;pre-clinical;prognostic;Reporting;Research;Research Project Grants;response;Risk;Signal Transduction;Sleep;Sleep Architecture;Sleep disturbances;sleep pattern;Sleep Stages;smart ring;smart watch;SPI1 gene;Statistical Models;Surface;tau Proteins;Technology;Temperature;Testing;Training;trait;TREM2 gene;wearable data;wearable device;Writing

PROJECT_TITLE: Genomics-guided sleep biomarker discovery for early Alzheimer's disease: A wearables study

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


NIH_SPENDING_CATS: Autoimmune Disease;Brain Disorders;Genetics;Multiple Sclerosis;Neurodegenerative;Neurosciences

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

PHR: PROJECT NARRATIVE  Multiple sclerosis (MS) remains an insidious disease, with unpredictable outcomes. Though the typical form of the disease, in which there are relapses and remissions, is responsive to many new medications, ultimately nearly seventy percent of patients go onto a secondary progressive phase for which there is currently no effective treatment. This application details experiments to understand the make-up and function of particular structures that appear in the brain and spinal cord uniquely during this progressive phase – meningeal ectopic lymphoid tissues (mELTs) – potentially highlighting new therapeutic treatments for progressive MS.

PI_NAMEs: PACHTER, JOEL S (contact)

PROGRAM_OFFICER_NAME: UTZ, URSULA

PROJECT_TERMS: 3-Dimensional;Anatomy;Animal Model;Animals;Anti-Inflammatory Agents;Appearance;Area;Attention;Autoimmune;Axon;B-Lymphocytes;Biological Response Modifiers;Blood Vessels;Brain;cell type;Cells;Clinical;Coupled;Cytometry;Data;Demyelinations;design;Disease;Disease remission;effective therapy;Elements;Exhibits;experimental study;Fluorescence Microscopy;Future;Gene Expression;Gene Expression Profile;Genetic Transcription;Habitats;Histologic;Image;Immune;Immune response;Immunologic Factors;In Situ;Individual;Inflammation;Inflammatory;laser capture microdissection;Lesion;Light;Literature;Locales;Location;Lymphoid Tissue;Mediating;Meningeal;Meninges;Methodology;Microglia;Microscopic;Modeling;Molecular;mouse model;Multiple Sclerosis;multiple sclerosis patient;multiple sclerosis treatment;Myelin Sheath;Nature;Nerve Degeneration;neuroinflammation;neuron loss;new therapeutic target;novel;novel therapeutics;Outcome;Pathogenesis;Pathogenicity;Pathologic;Pathology;Patients;Pharmaceutical Preparations;Phase;Play;Population;preservation;Process;Progressive Disease;prospective;Rain;Refractory;Relapse;Relapsing-Remitting Multiple Sclerosis;Research;Research Project Grants;Resolution;RNA;Role;Scanning Electron Microscopy;Secondary Progressive Multiple Sclerosis;Secondary to;segregation;Seminal;spatiotemporal;Spinal Cord;Stromal Cells;Structure;Subarachnoid Space;Suggestion;Technology;tertiary lymphoid organ;Testing;Therapeutic;Therapeutic Intervention;three dimensional structure;Time;transcriptome;transcriptome sequencing;transcriptomics;United States National Institutes of Health

PROJECT_TITLE: Meningeal ectopic lymphoid tissues (mELTs): Composition, organization and expression revealed by imaging and in situ transcriptomics

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome;Infectious Diseases;Precision Medicine

ORG_STATE: IL

PHR: PROJECT NARRATIVE This project aims to develop a new gene editing platform for understanding how natural human genetic variation can influence disease progression and drug efficacy. As proof-of-principle, this platform will be first be used to systematically characterize how variants of the HIV-1 co-receptor CCR5 can influence receptor expression, HIV infection, and antiretroviral drug activity. Ultimately, this work seeks to provide new technologies and paradigms for efficiently and rapidly exploring the influence of human genetic variation on disease outcomes and treatment efficacy to enhance the speed of future therapeutic development.

PI_NAMEs: HULTQUIST, JUDD F (contact)

PROGRAM_OFFICER_NAME: KANG, KIHWA

PROJECT_TERMS: Alleles;antagonist;Anti-Retroviral Agents;Autologous Transplantation;Benchmarking;Biological;Biological Process;Biological Response Modifier Therapy;CCR5 gene;CD4 Positive T Lymphocytes;Cell Line;Cell surface;Cells;Classification;Clinical;Clinical Management;Code;cohort;Communicable Diseases;Complex;cost;cost effective;CRISPR/Cas technology;deep sequencing;Development;Disease;Disease Management;Disease Outcome;Disease Progression;drug efficacy;Drug Targeting;druggable target;Engineering;experimental study;functional genomics;Future;gene editing technology;gene-editing approach;Genes;genetic makeup;genetic variant;Genetic Variation;genomic platform;Genotype;Goals;Haploidy;Health;Hematopoietic Stem Cell Transplantation;HIV;HIV Infections;HIV-1;Human;human disease;Human Genetics;Individual;Infection;innovation;Integration Host Factors;Introns;Jurkat Cells;Knock-in;Knock-out;Length;Libraries;Link;Maps;Modality;Monitor;mutant;Mutation;National Center for Advancing Translational Sciences;new technology;novel;novel strategies;Nucleotides;Observational Study;Oligonucleotides;Outcome;Outcome Measure;Pathogenesis;Pharmaceutical Preparations;Phenotype;Population;precision medicine;Predisposition;receptor;receptor expression;repaired;Reporting;Research;Resistance;resistance mutation;Resolution;Ribonucleoproteins;risk stratification;RNA;Role;screening;single cell sequencing;Single-Stranded DNA;Sorting;Speed;T-Lymphocyte;Testing;therapeutic development;Treatment Efficacy;Treatment outcome;Treatment Protocols;Tube;Untranslated Regions;Validation;Variant;Viral Pathogenesis;Work

PROJECT_TITLE: A Functional Genomics Platform for the de novo Identification of Disease-relevant Alleles

STUDY_SECTION: GVE

STUDY_SECTION_NAME: Genetic Variation and Evolution Study Section[GVE]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences;Prevention;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human

ORG_CITY: NEW YORK

ORG_DEPT: NEUROSCIENCES

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: The causal role of Alzheimer’s disease (AD) risk variants in neuronal or glial cells is unresolved.  By combining genetic fine-mapping, CRISPR-genetic engineering, and human induced pluripotent   stem cell models, we propose to test the molecular and functional impact of perturbing the  genotype of AD risk alleles. We hope to find insights into the mechanism of disease initiation and  progression in AD, in order to one day reverse the disrupted molecular pathways that contribute to this debilitating disorder.

PI_NAMEs: BRENNAND, KRISTEN JENNIFER;RAJ, TOWFIQUE  (contact)

PROGRAM_OFFICER_NAME: GRAY, ERIN EMILY

PROJECT_TERMS: Abeta clearance;Affect;age related neurodegeneration;Alternative Splicing;Alzheimer's Disease;Alzheimer's disease risk;Amyloid beta-Protein;Astrocytes;Autophagocytosis;Autopsy;base editing;Biological Assay;brain cell;causal variant;Cell Line;Cell Physiology;Cell Survival;cell type;Cells;Central Nervous System;Chromatin;Clustered Regularly Interspaced Short Palindromic Repeats;Coculture Techniques;Data Set;Dementia;Disease;disease model;Disease susceptibility;disorder risk;Etiology;Gene Expression;Genes;Genetic;genetic association;Genetic Engineering;Genetic Risk;Genetic Transcription;genetic variant;Genome;Genome engineering;genome wide association study;Genotype;glial activation;Goals;histone modification;Human;human induced pluripotent stem cells;Impaired cognition;Individual;insight;Intervention;Knowledge;late endosome;Maps;Mediating;Messenger RNA;Microglia;Modeling;Molecular;Myelin;Myeloid Cells;Neurites;Neurofibrillary Tangles;Neuroglia;neuron loss;Neurons;novel diagnostics;novel therapeutic intervention;novel therapeutics;Pathogenesis;Pathologic;Pathway interactions;patient stratification;Phagocytosis;Phenotype;prevent;protective allele;protein aggregation;Protein Isoforms;proteostasis;Quantitative Trait Loci;rare variant;Research;Risk;risk variant;RNA;RNA Splicing;Role;Senile Plaques;Signal Transduction;Single Nucleotide Polymorphism;Spliced Genes;standard care;stem cell based approach;stem cell model;Susceptibility Gene;tau Proteins;Testing;therapeutic candidate;transcriptomics;Translational Research;uptake;Variant;Work

PROJECT_TITLE: Modeling the impact of regulatory and splicing variants on cellular function in Alzheimer's disease

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]