NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biotechnology;Brain Disorders;Dementia;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Prevention

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: Cognitive Computing of Alzheimer’s Disease Genes and Risk Alzheimer’s Disease (AD) is devastating and its social and economic impact is projected to rise dramatically. Here, in order to discover genes that underlie its mechanisms and clinical risk, we fuse a new mathematical and machine learning framework with experimental testing in diverse models. The outcome will integrate vast amounts of data from evolution, from genome sequencing from experiments and from patients to guide clinical assessment of risk and open new paths for understanding the disease and for drug development.

PI_NAMEs: LICHTARGE, OLIVIER  (contact)

PROGRAM_OFFICER_NAME: YAO, ALISON Q

PROJECT_TERMS: Acceleration;Affect;Aging;Algorithms;Alleles;Alzheimer associated neurodegeneration;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease patient;Alzheimer's disease related dementia;Alzheimer's disease risk;Alzheimer’s disease biomarker;Amyloid beta-Protein;Apolipoprotein E;Attention;Automobile Driving;Autopsy;Back;Benign;Biological Assay;Biological Markers;Biological Models;Blinded;Brain;Calculi;Candidate Disease Gene;causal variant;Cell Culture Techniques;Cells;Classification;Clinical;Clinical assessments;clinical risk;Code;cognitive computing;cohort;Communities;Data;data modeling;Dementia;design;Development;Disease;Disease stratification;Drosophila genus;drug development;economic impact;Elderly;Evaluation;Evolution;experimental study;Face;fitness;Fogs;Functional disorder;Future;Gender;gene discovery;Gene Expression Profile;Gene Modified;Gene Mutation;gene network;Genes;Genetic;genetic architecture;Genetic Markers;genetic variant;Genome;genome sequencing;genome wide association study;genomic variation;Genomics;Goals;Heritability;Human;human data;Human Genome;in vivo evaluation;Individual;innovation;insight;Intervention;Link;Machine Learning;machine learning framework;mathematical analysis;mathematical learning;mathematical model;Medicine;men;Missense Mutation;Modeling;Molecular;Morbidity - disease rate;Mus;Mutation;Mutation Analysis;nerve stem cell;Neuronal Dysfunction;Neurons;neuropathology;neurotoxicity;Noise;novel;novel strategies;Onset of illness;Outcome;Pathogenesis;Pathogenicity;Pathway interactions;Patients;Performance;Pharmaceutical Preparations;Phenotype;Population;Population Attributable Risks;prevent;Preventive;programs;Proteins;Recording of previous events;Regression Analysis;Research;Resolution;Rest;Risk;Risk Assessment;risk stratification;robot assistance;Running;screening;Signal Transduction;social;Social Impacts;Sorting;Stratification;success;Symptoms;System;tau Proteins;Testing;text searching;theories;Therapeutic;Therapeutic Trials;Thinness;Time;tool;Translating;Untranslated RNA;Validation;Variant;Western Blotting;Woman;Work

PROJECT_TITLE: Cognitive Computing of Alzheimer's Disease Genes and Risk


ADMINISTERING_IC: AG

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Social Determinants of Health

ORG_CITY: DURHAM

ORG_COUNTRY: UNITED STATES

ORG_DEPT: SOCIAL SCIENCES

ORG_FIPS: US

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Project Narrative Social relationships are some of the most robust predictors of human health and mortality risk known to date. This project investigates how their dynamics across the life course are reflected at the molecular level, by combining a powerful animal model for human social behavior with genomic analyses of gene expression in the immune system. By studying the types and timing of the social ties that matter most, and by linking gene expression data with information on immune function and lifespan, this work will provide important insight into the mechanisms that connect social relationships to health, disease risk, and survival.

PI_NAMEs: ALBERTS, SUSAN C. (contact)

PROGRAM_OFFICER_NAME: GERALD, MELISSA S

PROJECT_TERMS: Address;Adult;Affect;Aging;aging related disease;Aleurites;Alleles;Animal Model;Animals;Bacterial Infections;Biological;Biological Markers;Birth;Blood;Blood specimen;Brain;Cause of Death;Chromatin;Clinical;cohort;Complex;Coupling;Data;Diet;disorder risk;DNA-Binding Proteins;Ecosystem;Environment;Environmental Risk Factor;Exercise;experience;functional genomics;gene environment interaction;Gene Expression;Gene Expression Profiling;Gene Expression Regulation;Generations;Genes;Genetic;Genetic Variation;genome-wide analysis;genomic data;genomic signature;Genomics;Genotype;Glucocorticoids;Goals;Grain;Health;Heart Diseases;Human;human model;immune function;Immune system;immunoregulation;Individual;Infant;Infection;Innate Immune Response;insight;Joints;Kenya;Life;Life Cycle Stages;life span;Ligands;Link;Loneliness;Longitudinal Studies;Malignant Neoplasms;Maps;Measures;Mediating;Modeling;Molecular;Molecular Profiling;Morbidity - disease rate;mortality;mortality risk;nonhuman primate;Papio;pathogen;Pathway interactions;Peripheral;Phenotype;Physiological;Population;Predisposition;Recording of previous events;Research Design;response;Risk;Risk Behaviors;Role;sample collection;Sampling;sex;Signal Pathway;Silk;Skin;social;Social Behavior;Social Environment;social integration;Social isolation;social relationships;Social status;Social support;Study Subject;Surveys;Testing;Time;Tissues;transcriptome sequencing;United States;Variant;Viral;Virus Diseases;Work

PROJECT_TITLE: Gene regulation and social relationships across the life course in a nonhuman primate model


ADMINISTERING_IC: DK

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Complementary and Integrative Health;Digestive Diseases;Estrogen;Genetics;Liver Disease;Nutrition;Obesity

ORG_CITY: RIVERSIDE

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA RIVERSIDE

ORG_STATE: CA

PHR: Project Narrative The optimal balance between carbohydrates (“carbs”) and lipids (fats) in the diet remains a hotly debated topic within both the scientific and medical communities, as well as the general public. In this proposal, we explore the molecular mechanisms responsible for the metabolic switch between carbohydrate and lipid metabolism in the liver, kidney and intestines. The results from our studies will enhance our understanding of the popular ketogenic diet and intermittent fasting, and shed light on the metabolic differences between males and females.

PI_NAMEs: SLADEK, FRANCES M. (contact)

PROGRAM_OFFICER_NAME: LIANG, HANYU

PROJECT_TERMS: 5'-AMP-activated protein kinase;Ablation;Acetylation;Adult;Aging;American;Biogenesis;Brain;carbohydrate metabolism;Carbohydrates;Cardiovascular system;Chemicals;Communities;Data;Deacetylase;Deacetylation;Dementia;Diabetes Mellitus;Diet;dieting;Diurnal Rhythm;Drug Prescriptions;Effectiveness;Energy Metabolism;Enzymes;Equilibrium;ESR1 gene;Estrogens;Exons;experience;experimental study;Fasting;Fatty acid glycerol esters;fatty liver disease;feeding;Female;Fetal Liver;Gene Expression;General Population;Genes;Gluconeogenesis;Glucose;glucose metabolism;Goals;Health;Hepatocyte;hepatocyte nuclear factor;High Fat Diet;HNF4A gene;In Vitro;in vivo;inhibitor;Intermittent fasting;Intestines;ketogenesis;ketogenic diet;ketogentic;Ketone Bodies;Kidney;Knockout Mice;lipid metabolism;Lipids;Liver;male;Malignant neoplasm of liver;Maps;Mass Spectrum Analysis;maturity onset diabetes of the young;Mediating;Medical;Metabolic;Metabolic Diseases;Metabolism;Metformin;Mitochondria;Molecular;Mus;Mutate;Nervous System Disorder;Neurologic;Nuclear Receptors;Obesity;Obesity Epidemic;Pathway interactions;Phosphorylation;Phosphorylation Site;Phosphotransferases;Physiological;Play;Process;promoter;Protein Isoforms;Proteins;Research;response;Role;sex;SIRT1 gene;Source;sugar;Tissues;translational impact;trend;weight loss program;Wild Type Mouse;Work

PROJECT_TITLE: Balance between HNF4a isoforms in the carbohydrate-lipid metabolic switch

STUDY_SECTION: CSME

STUDY_SECTION_NAME: Cell Signaling and Molecular Endocrinology Study Section[CSME]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: GAINESVILLE

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE (Overall Component) Vaccines are one of the most cost effective and extraordinarily successful medical interventions. We propose to pursue an in-depth knowledge of the transcription factor regulation of protective antiviral CD4 and CD8 T cell responses to facilitate an understanding of Tfh cells, cytotoxic CD8 T cells, and memory CD4 and CD8 T cells for rationale vaccine design and tumor immunotherapy.

PI_NAMEs: PIPKIN, MATTHEW EUGENE (contact)

PROGRAM_OFFICER_NAME: MALLIA, CONRAD M

PROJECT_TERMS: adaptive immunity;Antibody Response;B-Lymphocytes;Biology;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;Cells;Cellular biology;CHD7 gene;Chromatin;Complex;Consumption;cost effective;Custom;cytotoxic CD8 T cells;Cytotoxic T-Lymphocytes;Data;Development;Effector Cell;effector T cell;epigenetic regulation;experience;experimental study;Gene Expression;Gene Expression Regulation;Generations;Genes;Genetic Epistasis;Genetic Screening;Genetic Transcription;Helper-Inducer T-Lymphocyte;Heterogeneity;Histone Deacetylase;Human;Immunity;in vivo;insight;Intervention;IRF4 gene;Knockout Mice;Knowledge;Libraries;Link;Malignant Neoplasms;Medical;Memory;memory CD4 T lymphocyte;Molecular;Nature;neoplasm immunotherapy;NuRD complex;Paper;pathogen;Pathway interactions;Peptide Initiation Factors;Population;Process;programs;Provider;Regulation;Regulator Genes;Role;RUNX3 gene;synergism;System;T cell differentiation;T cell response;T memory cell;T-Lymphocyte;T-Lymphocyte Subsets;Technology;technology development;Testing;Time;Tissues;transcription factor;tumor;Vaccine Design;Vaccines;vector;Viral;Virus Diseases;Work

PROJECT_TITLE: Transcription factor regulation of CD4 and CD8 T cell effector and memory differentiation and function


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Clinical Research;Complementary and Integrative Health;Dietary Supplements;Genetics;Nutrition;Prevention

ORG_CITY: CHAPEL HILL

ORG_DEPT: NUTRITION

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: The ALDH1L1 gene in folate pathways has high frequency of non-synonymous polymorphisms with resulting haplotypes being different among human populations. The proposed research will functionally characterize haplotype-specific ALDH1L1 enzyme variants, determine how they differ in the regulation of folate and glycine metabolism, and define haplotype-specific metabotypes as a function of folate status and an indicator of metabolic health.

PI_NAMEs: KRUPENKO, SERGEY A (contact);SUMNER, SUSAN J;VORUGANTI, VENKATA SAROJA

PROJECT_TITLE: Mechanistic and metabolomic underpinnings of ALDH1L1 polymorphisms in the regulation of glycine metabolism

STUDY_SECTION: NMHD

STUDY_SECTION_NAME: Nutrition and Metabolism in Health and Disease Study Section[NMHD]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Human Genome;Infectious Diseases

PI_NAMEs: CROTTY, SHANE P (contact)

PROJECT_TERMS: Animals;ATAC-seq;Bioinformatics;Budgets;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Core Facility;Data;Doctor of Philosophy;editorial;effector T cell;Funding;Genetic Screening;Goals;Grant;Guide RNA;Home;Human;Infection;Information Technology;Institution;interest;Knowledge;Laboratories;Libraries;Lymphocytic choriomeningitis virus;Manuscripts;meetings;Memory;Modeling;Mus;Occupations;programs;Progress Reports;Regulation;Research Personnel;symposium;synergism;System;T cell differentiation;Technology;Training;transcription factor;transcriptome sequencing;Transgenic Animals;United States National Institutes of Health;Update;Viral;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Biotechnology;Gene Therapy;Genetics

PROJECT_TERMS: acute infection;analysis pipeline;B-Lymphocytes;Biological;CD8-Positive T-Lymphocytes;Cell Maintenance;Cell Physiology;Cell Surface Receptors;Cells;Chromatin;Cloning;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Complement;Core Facility;CRISPR/Cas technology;Custom;Data;Development;differential expression;DNA;DNA Library;Doctor of Philosophy;effector T cell;Evolution;experience;flexibility;Follow-Up Studies;gene function;Gene Targeting;Gene Transfer;Generations;Genes;genome-wide;Goals;Guide RNA;Human;Immune response;Immune system;In Vitro;in vivo;Individual;Infection;innovation;Laboratories;Lentivirus Vector;Libraries;loss of function;Mediating;Memory;Methods;MicroRNAs;Mus;novel;novel strategies;Phenotype;plasmid DNA;Publishing;Reagent;Regulation;Research Institute;Retroviral Vector;RNA Interference;small hairpin RNA;Susceptibility Gene;System;T-Lymphocyte;Technology;tissue resident memory T cell;tool;transcription factor;Transfection;tumor;vector;virtual

PROJECT_TITLE: shRNAmir and CRISPR sgRNA Library Construction Core


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision

ORG_CITY: NEW YORK

ORG_DEPT: GENETICS

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: Project Narrative In organs of the body, cells that occupy defined positions are specialized to perform precise functions. This application uses the developing eye of Drosophila (the fruit fly) as a model system to understand how a cell’s position and its type are so precisely coordinated.

PI_NAMEs: TOMLINSON, ANDREW  (contact)

PROGRAM_OFFICER_NAME: WRIGHT, CHARLES BAKER

PROJECT_TERMS: Address;Adhesions;Adhesives;Affinity;Animals;Biological;Biological Models;cell behavior;Cell Differentiation process;cell fate specification;cell motility;Cells;compound eye;Development;differential expression;Drosophila eye;Drosophila genus;Epithelium;Eye;fly;Goals;insight;Link;Medial;Molecular;neural model;notch protein;Notch Signaling Pathway;Organ;Pathway interactions;Pattern;Phase;Photoreceptors;Play;Positioning Attribute;Process;programs;Property;Proteins;Receptor Protein-Tyrosine Kinases;recruit;Retina;Signal Pathway;Signal Transduction;Specific qualifier value;Structure;System;Testing;Work

PROJECT_TITLE: The Drosophila Ommatidium: a model neural system for cell recruitment and fate specification during development

STUDY_SECTION: BVS

STUDY_SECTION_NAME: Biology of the Visual System Study Section[BVS]


PROJECT_TERMS: Address;Algorithms;ATAC-seq;Award;B-Lymphocytes;Base Pairing;Binding;Binding Sites;Bioinformatics;bioinformatics pipeline;CD8-Positive T-Lymphocytes;Cell Count;Cell Physiology;Cells;Cellular Immunity;ChIP-seq;Chromatin;chromatin immunoprecipitation;chromatin remodeling;Chromatin Structure;Cloning;Clustered Regularly Interspaced Short Palindromic Repeats;Computer Analysis;Core Facility;Creativeness;Data;Data Analyses;data management;Dedications;DNA;DNA Polymerase II;DNA-Protein Interaction;Doctor of Philosophy;effector T cell;Epigenetic Process;Event;Evolution;experience;experimental study;Faculty;Gene Expression;Gene Expression Profiling;gene regulatory network;Genes;Genetic Transcription;genome-wide;genomic data;Genomics;Goals;Guide RNA;histone modification;Human Resources;Immune response;in vivo;Individual;Infection;innovation;instrument;Laboratories;large datasets;Libraries;loss of function;Lymphocyte;Maps;Measures;Memory;Messenger RNA;Methods;Micrococcal nuclease digestion of chromatin followed by sequencing;Molecular;mRNA Expression;next generation sequencing;Nucleic Acid Regulatory Sequences;Nucleosomes;programs;Recording of previous events;Regulation;Research Institute;Resolution;RNA;RNA Interference;RNA interference screen;RNA library;RNA Sequences;Sampling;Services;Standardization;System;T cell differentiation;T cell regulation;T-Lymphocyte Subsets;tool;transcription factor;transcriptome sequencing;tumor

PROJECT_TITLE: Gene expression, Epigenetics and Bioinformatics Core


PROJECT_TERMS: adaptive immunity;Address;Antibody Affinity;Antibody Response;Autoimmunity;B-Lymphocytes;Biology;BLR1 gene;candidate identification;CD 200;CD30L;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Communication;Cell Differentiation process;Cell Physiology;Cells;Chromatin;Civilization;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;cost effective;CRISPR/Cas technology;Data;Development;Disease;effector T cell;experimental study;Future;GATA3 gene;gene repression;Genes;genetic signature;Helper-Inducer T-Lymphocyte;Human;Humoral Immunities;Immune response;Immunity;Immunobiology;Immunoglobulin Somatic Hypermutation;improved;Interleukin-2;interleukin-21;Knowledge;Laboratories;Light;Medical;Memory;Memory B-Lymphocyte;Modeling;Modernization;Molecular;mouse model;pathogen;Pathway interactions;Plasma Cells;Process;programmed cell death protein 1;programs;Provider;Regulation;Repression;RUNX3 gene;Scourge;Series;Structure of germinal center of lymph node;synergism;T cell differentiation;T-Lymphocyte;Technology;Testing;TNFSF11 gene;tool;transcription factor;vaccine development;Vaccines;vaccinology;Viral Antibodies;Work

PROJECT_TITLE: Bcl6 and transcription factors that program TFH differentiation and function


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_DEPT: NEUROLOGY

PHR: OVERALL NARRATIVE The overall objective of the P30 ADRC at Columbia University is to support an elaborate but well-integrated research infrastructure to tackle barriers in the field of Alzheimer’s disease and related disorders, which include early detection, prevention and intervention. Embedded within this general objective, the Center’s infrastructure will focus on a group of biological pathways that have emerged as pathogenic drivers of AD. The Center will promote outreach and patient recruitment, provide a rich training environment, and will participate in all national coordinating efforts.

PI_NAMEs: SMALL, SCOTT A (contact)

PROGRAM_OFFICER_NAME: SILVERBERG, NINA B

PROJECT_TERMS: Address;Advisory Committees;Alzheimer's Disease;Alzheimer's disease related dementia;amyloid pathology;Awareness;Biological;Biological Markers;career;Cell Physiology;Cholesterol Homeostasis;Clinical;Clinical Investigator;Clinical Trials;Collaborations;Committee Members;Communities;community organizations;data management;data submission;Discipline;Disease;Early Diagnosis;education research;Endosomes;Enrollment;Environment;Fostering;Genes;Genetic;Genomics;Goals;Immune response;Infrastructure;Institution;interdisciplinary collaboration;interest;Intervention;Learning Module;Mission;Nerve Degeneration;neuroimaging;neuroimmunology;neuropathology;Observational Study;outreach;Participant;Pathogenesis;Pathogenicity;Pathology;Pathway interactions;Patient Care;patient outreach;Patient Recruitments;Patients;Pharmaceutical Preparations;phenomenological models;prevent;Prevention;programs;recruit;Research;Research Infrastructure;Research Personnel;Resources;success;synergism;tau Proteins;Therapeutic Trials;Time;tool;trafficking;Training;translational scientist;United States National Institutes of Health;Universities;Vision;Work

PROJECT_TITLE: Alzheimer's Disease Research Center


PROJECT_TERMS: Acute;Address;Adoptive Transfer;Affect;Alleles;Automobile Driving;Binding Sites;Biochemical;CD8-Positive T-Lymphocytes;CD8B1 gene;Cells;CHD7 gene;Chromatin;chromatin remodeling;Chromatin Remodeling Factor;Chromatin Structure;Complex;cytotoxic CD8 T cells;Cytotoxic T-Lymphocytes;Development;effector T cell;Ensure;Exhibits;experimental study;Family;Genes;Genetic Transcription;Goals;Half-Life;Histone Acetylation;Histone Deacetylase;Hour;Human;Immunity;immunodeficiency;Immunotherapy;in vivo;Individual;Infection;Infiltration;insight;Lead;Link;loss of function;Lymphocytic choriomeningitis virus;Maps;Mass Spectrum Analysis;Mediating;Memory;Memory impairment;Molecular;Mutate;Nucleic Acid Regulatory Sequences;Nucleosomes;NuRD complex;Pathway interactions;Peptide Initiation Factors;Phase;Phenotype;Physical condensation;prevent;Process;programs;Proteins;recruit;Regulation;Reporter;Repression;RNA Interference;RNA interference screen;Role;RUNX3 gene;single-cell RNA sequencing;Site;synergism;T-Cell Development;T-Cell Receptor;T-Lymphocyte;Tissues;transcription factor;Transcriptional Regulation;transcriptional reprogramming;tumor;Vaccines;Virus Diseases

PROJECT_TITLE: Chromatin and transcriptional regulatory factors that initiate and stabilize memory CD8 T cell development


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

PROJECT_TERMS: Administrator;Advisory Committees;Advocacy;Alzheimer's Disease;Alzheimer's disease therapeutic;Awareness;Biological;Biological Markers;career;cell repository;Charge;Cholesterol Homeostasis;Collaborations;community center;Community Outreach;cooperative study;Data;Dedications;Development;Disease;education research;Endosomes;Environment;Exercise;flexibility;Fostering;Funding;Genetic;Goals;high standard;Image;Immune response;innovative technologies;Institution;interdisciplinary collaboration;Intervention;Leadership;meetings;Mind;Mission;Monitor;National Institute on Aging;Neurologic;Neuropsychology;outreach;Participant;Pathogenicity;Pathway interactions;Patient Care;Patient Recruitments;Patients;prevent;Process;programs;recruit;Research;Research Infrastructure;Research Institute;Research Personnel;Resources;trafficking;Training;Universities;Vision;Work


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Neurodegenerative;Neurosciences

PI_NAMEs: NOBLE, JAMES MCCALLUM (contact)

PROJECT_TERMS: Address;African American population;Aging;Alzheimer's Disease;Alzheimer's Disease Pathway;Alzheimer's disease related dementia;Area;Autopsy;Basic Science;Biological;Biological Markers;biomarker panel;Blood;Blood Cells;Blood specimen;Brain;Brain imaging;brain tissue;Caregivers;Cells;Cerebrospinal Fluid;Cessation of life;Clinical;clinical center;Clinical Data;Clinical Research;Clinical Trials;Code;cohort;Collaborations;Data;data cleaning;Data Collection;Data Coordinating Center;Data Element;data exchange;data management;Data Set;data standards;Database Management Systems;demented;Dementia;Dementia with Lewy Bodies;Diagnosis;Diagnostic;Disease;DNA;Enrollment;Ensure;Environment;ethnic diversity;Evaluation;Extramural Activities;Family;Frontotemporal Dementia;Funding;Genetic;Genetic study;Goals;Hispanic Populations;Image;Immunologics;Impaired cognition;Impairment;improved;Individual;instrument;International;Interview;Liquid substance;Magnetic Resonance Imaging;Medical;mild cognitive impairment;multi-ethnic;neuroimaging;neuroimmunology;Neurologic;neuropathology;Neuropsychological Tests;Neuropsychology;New York;outreach;Participant;participant enrollment;Pathway interactions;patient engagement;Patient Recruitments;Peripheral Blood Mononuclear Cell;Persons;Pharmaceutical Preparations;Plasma;Population;Preparation;Quality Control;randomized, clinical trials;recruit;repository;Research;Research Personnel;Resource Sharing;Resources;Sampling;Scientist;Site;skills;social;Specific qualifier value;Specimen;Spinal Puncture;Students;symposium;Testing;Time;Tissues;Training;training opportunity;Translational Research;transmission process

PROJECT_TITLE: Clinical Core


NIH_SPENDING_CATS: Cancer;Clinical Research;Genetics;Immunization;Immunotherapy;Infectious Diseases;Vaccine Related

PI_NAMEs: GOLDRATH, ANANDA W (contact)

PROJECT_TERMS: cancer immunotherapy;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Physiology;Cells;Characteristics;Chromatin;Chromatin Modeling;clinically relevant;cytotoxic;Data;Dependence;Disparate;Effector Cell;effector T cell;Epigenetic Process;experimental study;Exposure to;flexibility;Generations;Genetic Transcription;Genome;Goals;Heterogeneity;Human;Immunity;immunopathology;In Situ;in vivo;Infection;Infrastructure;Laboratories;Longevity;Lymphocyte;Lymphoid;Maintenance;Malignant Neoplasms;Mediating;Memory;memory CD4 T lymphocyte;novel;pathogen;Population;programs;Proliferating;Regulation;response;Role;Site;small hairpin RNA;Source;stem;T cell differentiation;T memory cell;T-Cell Activation;T-Lymphocyte;T-Lymphocyte Subsets;Technology;Testing;Therapeutic;Tissues;transcription factor;tumor;Tumor Immunity;tumor microenvironment;Tumor-Infiltrating Lymphocytes;vaccine strategy;Vaccines;Virus Diseases

PROJECT_TITLE: Regulation of memory T cell differentiation and long-term maintenance


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_DEPT: BIOLOGY

ORG_NAME: NEW YORK UNIVERSITY

PHR: Drosophila, with its genetic amenability and simple visual system, yet very sophisticated visual performances, is a very powerful model system to study how the visual system is built during development. Using the results of single cell mRNA sequencing, we investigate the mechanisms controlling specific connections among optic lobe neurons and how the formation of the different layers of visual processing is coordinated. The principles deduced from this project will be applicable to other sensory systems such as the mammalian retina.

PI_NAMEs: DESPLAN, CLAUDE  (contact)

PROJECT_TERMS: Adult;Axon;Behavior;Behavior Control;Biological Models;Birth Order;Brain;brain control;Brain region;cell type;Cells;Color;Complement;Cone;Data;Dendrites;detector;Development;Drosophila genus;Elements;experimental study;fly;Flying body movement;Funding;Ganglia;Genetic;Genomics;Grant;Individual;insight;Interneurons;large datasets;Location;Maps;Mediating;Modeling;Molecular;Molecular Genetics;Motion;nerve stem cell;neural;neurogenesis;Neuroglia;Neurons;Neuropil;novel;Optic Lobe;Optics;orientation selectivity;Output;Pathway interactions;Pattern;Photoreceptors;Positioning Attribute;Process;programs;Recording of previous events;Resources;Retina;Retinal Ganglion Cells;retinotopic;Rhodopsin;Rod;Role;Sensory;sensory system;Signal Transduction;single cell mRNA sequencing;single-cell RNA sequencing;Speed;Testing;tool;transcriptome;transcriptomics;Vertebrates;Visual;visual information;visual performance;visual processing;Visual System

PROJECT_TITLE: Circuit formation in the visual centers

STUDY_SECTION: NDPR

STUDY_SECTION_NAME: Neurodifferentiation, Plasticity, Regeneration and Rhythmicity Study Section[NDPR]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences

PI_NAMEs: ANDREWS, HOWARD F. (contact)

PROJECT_TERMS: Adult;Alzheimer's Disease;Alzheimer’s disease biomarker;Biological;Biometry;Clinical;cohort;Communities;Consultations;Data;Data Coordinating Center;Data Element;data integration;data management;data quality;data resource;data sharing;data submission;Database Management Systems;Databases;design;Development;Doctor of Philosophy;Doctor's Degree;Down's Syndrome;Ensure;Epidemiologist;Epidemiology;experience;Faculty;Frontotemporal Lobar Degenerations;Funding;Genetic;Goals;high standard;Image;Information Systems;Infrastructure;longitudinal analysis;Master of Science;Medical center;Medical Research;member;Methods;multidimensional data;neuroimaging;neuropathology;Pathogenicity;Pathway interactions;Planning Techniques;Procedures;programs;psychobiology;Psychophysiology;Records;relational database;Reporting;Research;Research Design;Research Personnel;Research Support;Resource Sharing;Resources;Role;Secure;Security;software infrastructure;Spanish/English;Specialist;Specimen;Statistical Data Interpretation;Structure;System;Text;Training;Universities;Work

PROJECT_TITLE: Data Management and Statistical Core


ORG_CITY: CAMBRIDGE

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

ORG_STATE: MA

PHR: The Papez circuit consists of several extra-hippocampal structures, which, although thought to be necessary for memory, are much less studied in Alzheimer’s disease. Recent work from our lab indicates that specific neurons in the mammillary body (MB) are preferentially affected in AD, particularly in terms of hyperactivity, but how these neurons are connected in the circuit, and what the cause and the long-term effects of the hyperactivity of these specific neurons are not known. We will use cutting-edge neuroscience techniques developed in our group to investigate the important aspects of this memory circuit in AD.

PI_NAMEs: BOYDEN, EDWARD S. (contact);TSAI, LI-HUEI

PROGRAM_OFFICER_NAME: GRAY, ERIN EMILY

PROJECT_TERMS: Affect;Alzheimer's Disease;Alzheimer's disease model;Amyloid;Amyloid deposition;apolipoprotein E-4;Area;Automobile Driving;Axon;Behavior;Behavioral;Brain;Dementia;Deposition;Efferent Neurons;Electrophysiology (science);Etiology;Exhibits;Goals;Grant;Hippocampus;Human;Hyperactivity;Image;in situ sequencing;in vivo;Investigation;Ion Channel;Label;Lateral;Link;Location;Long-Term Effects;Mammillary body structure;Maps;Medial;Memory;Microscopy;mouse model;Mus;Myelin;Nerve Degeneration;Neurons;Neurosciences;optogenetics;Pathology;Patients;Pattern;Performance;pharmacologic;Population;Population Analysis;Predisposition;Resolution;Sampling;segregation;Severities;single-cell RNA sequencing;Site;Slice;Source;Stains;Structure;Techniques;Testing;tool;tool development;translational potential;voltage;white matter;white matter change;Work;Zebrafish

PROJECT_TITLE: Mechanisms of pathology and neuronal hyperactivity in a memory circuit in Alzheimer's disease


PI_NAMEs: TEICH, ANDREW FRANKLIN (contact)

PROJECT_TERMS: Affect;Aliquot;Alzheimer's Disease;Alzheimer's disease related dementia;Anatomy;animal resource;Area;Autopsy;Bar Codes;Biological;Brain;brain tissue;cell type;Cessation of life;Clinical;clinical conference;Communities;Contralateral;Diagnosis;Diagnostic;Diagnostic Services;Disease;Dissection;Drug or chemical Tissue Distribution;Education;Eligibility Determination;entorhinal cortex;Evaluation;experience;Faculty;Formalin;Freezing;frontal lobe;Fusiform gyrus;Genes;Goals;Grouping;Hippocampus;Human;human tissue;Individual;Institution;International;Investigation;Methodology;Microscopic;Mission;Modeling;Molecular;multidisciplinary;Neurodegenerative Disorders;Neurology;neuropathology;next generation;novel;operation;Pathogenesis;Pathologic;Pathology;Pathway interactions;Patients;Pattern;Periodicals;Procedures;Process;Protocols documentation;Publications;Recording of previous events;Research;Research Personnel;Resources;Sampling;Services;single nucleus RNA-sequencing;Site;Slide;Speed;symposium;tau Proteins;Tissue Banks;Tissues;Training;TREM2 gene;Universities;Validation;Variant;Visit;Visual Cortex

PROJECT_TITLE: Neuropathology Core


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Infectious Diseases;Lung

ORG_CITY: PITTSBURGH

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE Immune cells in the lung have important functions both during infection and homeostasis. Their appropriate function in either context involves transmitting signals from lung microenvironment, and improper integration of these signals can lead to impaired pathogen clearance or excess inflammation and tissue damage. Our goal is to understand mechanisms that allow lung signals to shape immune function, to gain insights into susceptibility to infection and chronic inflammatory lung diseases.

PI_NAMEs: GOTTSCHALK, RACHEL A (contact)

PROGRAM_OFFICER_NAME: ESPINOZA-PINTUCCI, MARISOL

PROJECT_TERMS: Acute;Alveolar Macrophages;Anti-Inflammatory Agents;Bacterial Infections;Bacterial Pneumonia;Bone Marrow;cell type;Cells;chronic inflammatory lung disease;Chronic lung disease;cytokine;Cytokine Signaling;Development;Disease;Equilibrium;Event;Family;functional plasticity;Gases;Genes;Genetic Transcription;Goals;Granulocyte-Macrophage Colony-Stimulating Factor;Health;Homeostasis;Human;Immune;immune function;Immune response;Immunosuppression;Impairment;Infection;Inflammation;Inflammatory;Inflammatory Response;insight;Insulin-Like Growth Factor I;knock-down;Link;lipid metabolism;Lipids;Lung;Lung infections;Macrophage;MAP Kinase Gene;Metabolic;Metabolism;microbial;Minor;Modeling;Morbidity - disease rate;mortality;Mus;Mutation;pathogen;Pathology;pharmacologic;Phenotype;Phosphotransferases;Post-Translational Protein Processing;PPAR gamma;Predisposition;preference;Process;programs;Proteins;Proto-Oncogene Proteins c-akt;Pseudomonas aeruginosa;Pulmonary Alveolar Proteinosis;Pulmonary Surfactants;Recurrence;Resolution;Respiration;response;Role;Science;Shapes;Signal Pathway;Signal Transduction;Staphylococcus aureus;Stimulus;Structure of parenchyma of lung;Therapeutic;Tissues;transcription factor;transcriptome sequencing;transmission process;Upper Respiratory Infections;Variant;Work

PROJECT_TITLE: Linking steady-state cytokine signaling to alveolar macrophage function in homeostasis and lung infection

STUDY_SECTION: LIRR

STUDY_SECTION_NAME: Lung Injury, Repair, and Remodeling Study Section[LIRR]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences

PI_NAMEs: ARCE, MIGUEL  (contact)

PROJECT_TERMS: Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Area;Behavioral Genetics;Benefits and Risks;Biological;Biological Markers;brain health;Cerebrospinal Fluid;Cholesterol Homeostasis;CLIA certified;Clinical;Collaborations;Collection;Communities;community advisory board;Community Health Education;community organizations;Community Outreach;Data;data integration;data management;Databases;Dementia;Development;Education and Outreach;Educational Materials;effectiveness evaluation;Elements;Endosomes;Ethics;ethnic diversity;Evaluation;flexibility;Funding;Future;Goals;Health Personnel;Height;Immune response;improved;innovation;interest;Investigation;legal implication;Logistics;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;meetings;Methods;Neurologic;New York;outreach;Participant;Pathway interactions;Patient Recruitments;Persons;Play;Population;Population Heterogeneity;Positron-Emission Tomography;Procedures;programs;racial diversity;recruit;Registries;Reporting;Research;Resources;Risk;Role;searchable database;social implication;Source;Spanish/English;success;Surveys;trafficking;United States National Institutes of Health;Universities;volunteer;Washington;Work

PROJECT_TITLE: Outreach, Recruitment and Engagement Core


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Pediatric

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: There is a great shortage in the United States of qualified pediatrician-scientists, including pediatric endocrinologists, with a growing unmet need for better treatments of pediatric endocrine diseases like obesity and diabetes. These diseases pose a great threat to the future health of our nation's children (illustrated most recently by the increased risk conferred by obesity in the recent COVID-19 pandemic), and are a major source of health disparities. We hope that our training program, with strong mentors and educational opportunities, will address this need by guiding and supporting the early careers of a highly motivated and diverse group of pediatric endocrinology trainees, and inspiring them to become leaders in academic pediatric endocrinology and biomedical research.

PI_NAMEs: HIRSCHHORN, JOEL N (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TITLE: RESEARCH IN DEVELOPMENTAL ENDOCRINOLOGY AND METABOLISM

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Cerebrovascular;Dementia;Neurodegenerative;Neurosciences

PI_NAMEs: BRICKMAN, ADAM M (contact)

PROJECT_TERMS: Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer’s disease biomarker;Amyloid;APLP1 gene;Apolipoproteins;Biological;Biological Markers;Blood;brain magnetic resonance imaging;Cerebrospinal Fluid;cerebrovascular;Cerebrovascular Disorders;Cholesterol Homeostasis;Classification Scheme;Clinical;Cognitive aging;Collaborations;Communities;Data;data exchange;Data Sources;Data Store;Databases;Dementia;Detection;Development;Diagnostic;Disease;Endosomes;Etiology;exosome;Goals;Hemorrhage;Heterogeneity;Human;imaging biomarker;Immune response;Immunologic Markers;improved;in vivo;Infarction;Information Systems;instrumentation;interest;International;Light;Liquid substance;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Measurement;Methods;Molecular;MRI Scans;Nerve Degeneration;neurofilament;neuroimaging;neuroimaging marker;next generation;novel;novel marker;Participant;participant enrollment;Pathway interactions;Plasma;Positron-Emission Tomography;potential biomarker;Process;programs;Protocols documentation;Radiology Specialty;Research;Research Personnel;Research Proposals;Resources;Scanning;Scientist;Secure;Sensitivity and Specificity;single molecule;Standardization;Stream;sulfated glycoprotein 2;tau Proteins;Technology;Thick;trafficking;Training;training opportunity;Universities;White Matter Hyperintensity;Work

PROJECT_TITLE: Biomarker Core


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Women's Health Research

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: 8. Project Narrative Women with HIV (WWH) experience heightened systemic immune activation, which persists despite viral suppression with combination antiretroviral therapy. Heightened systemic immune activation, in turn, fuels pathology affecting the heart, lungs, kidneys, and brain and may also be relevant to ways the body responds to SARS-CoV-2 infection. A strong public health imperative exists to better understand consequences of persistent immune activation among ART-treated WWH – numbering 18 million globally.

PI_NAMEs: ZANNI, MARKELLA V. (contact)

PROGRAM_OFFICER_NAME: HUEBNER, ROBIN E

PROJECT_TERMS: Affect;Ancillary Study;antiretroviral therapy;Attention;attributable risk;Award;Biomedical Research;Biometry;Blood Vessels;Brain;Cardiology;Cardiometabolic Disease;cardiovascular disorder risk;Cardiovascular system;career;career development;catalyst;CD8-Positive T-Lymphocytes;Center for Translational Science Activities;Chronic;Clinical Investigator;clinical translation;Collaborations;Communities;comorbidity;Complement;Coronary;COVID-19;cytokine release syndrome;Dendritic Cells;Discipline;Disease;Dreams;Education;Educational workshop;Endocrine;Endocrinology;Enrollment;Environment;Epidemiology;Epigenetic Process;Event;Exhibits;experience;faculty mentor;frailty;Functional disorder;Funding;General Hospitals;Generations;Genes;Goals;healthspan;Heart;HIV;HIV-1;Hormonal;Immune;immune activation;Immune response;Immunology;immunoregulation;Inflammation;insight;Institution;Interferon alpha;Interferons;Kidney;Kidney Diseases;Lead;Leadership;Learning;Letters;Liver diseases;Lung;Massachusetts;medical schools;Medicine;men;Mentors;Mentorship;Metabolism;Microvascular Dysfunction;Mid-Career Clinical Scientist Award (K24);mid-career faculty;Midcareer Investigator Award in Patient-Oriented Research;Neurocognitive;Organ;Outcome;Participant;Pathology;patient oriented research;Patients;Pattern;Physiology;prevent;programs;Public Health;randomized trial;reproductive senescence;Research;research facility;Research Institute;Research Personnel;Research Project Grants;Research Training;response;Risk;Risk Reduction;risk selection;SARS-CoV-2 infection;Services;sex;sex as a biological variable;Sex Differences;skills;success;T-Cell Activation;Testing;Time;TLR7 gene;Training;United States National Institutes of Health;Up-Regulation;Viral;Viremia;Virus;Woman;Women's Health;women's treatment;Work

PROJECT_TITLE: Consequences of Persistent Immune Activation among ART-treated Women with HIV

STUDY_SECTION: AIDS

STUDY_SECTION_NAME: Acquired Immunodeficiency Syndrome Research Study Section[AIDS]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences

PI_NAMEs: REITZ, CHRISTIANE  (contact)

PROJECT_TERMS: Address;Alzheimer's Disease;Amyloid;biobank;Bioinformatics;Biological Markers;Cholesterol;Cholesterol Homeostasis;clinical database;cohort;Collection;Data;Data Analyses;data management;Data Set;Data Storage and Retrieval;Databases;Dementia;endophenotype;Endosomes;Environment;experience;Family;Funding;Generations;Genetic;genetic analysis;genetic association;Genetic Counseling;Genetic Databases;genetic epidemiology;Genetic Materials;Genetic Research;genetic resource;Genetic study;Genetic Variation;genome wide association study;genomic data;Genotype;Heterogeneity;Human Genetics;Immune response;Individual;Infrastructure;Laboratories;large scale data;Libraries;Link;Maps;Methods;Nerve Degeneration;neuroimmunology;neuropathology;next generation sequencing;Pathway interactions;Patients;Phenotype;precision medicine;Preparation;Process;repository;Research;Research Design;Research Personnel;Resources;Risk;Sampling;Sequence Analysis;Site;Support Groups;Targeted Research;Targeted Resequencing;tau Proteins;trafficking;Training;Training and Education;transcriptome sequencing;undergraduate education;Universities;Variant;Vertebral column;Vision;Work

PROJECT_TITLE: Genetics Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Immunotherapy;Neurodegenerative;Neurosciences

PI_NAMEs: DE JAGER, PHILIP L (contact)

PROJECT_TERMS: Acceleration;Activities of Daily Living;Age related pathologies;Alzheimer's Disease;Antibodies;Antigens;Area;Astrocytes;biobank;Biological Assay;Biological Markers;Biological Models;Budgets;cell bank;Cells;Cerebrospinal Fluid;Clinical;Cognitive;Collaborations;Collection;Communities;Cryopreservation;Data;data exchange;data resource;Databases;design;Development;Disease;Education;endophenotype;Evaluation;Family;Future;Genetic;Genetic study;Genetic Transcription;glial activation;Human;Immune;immune function;Immune response;Immune system;Immunotherapy;Individual;Infiltration;Inflammation;Innate Immune System;Investigation;Leucocytic infiltrate;Measures;Mediating;Mendelian randomization;Microglia;Minor;Molecular;monocyte;Morphology;Myeloid Cells;neuroimaging;neuroimmunology;novel;Participant;Pathogenicity;Pathologic;Pathway interactions;Patients;Peripheral;Peripheral Blood Mononuclear Cell;Phagocytes;Play;Population;Predisposition;prevent;Process;programs;Proteins;Proteome;Proxy;recruit;Research;Research Design;Research Personnel;Resources;response;Role;Sampling;Science;Stimulus;Structure;Surrogate Markers;Testing;transcriptome;transcriptome sequencing;Universities

PROJECT_TITLE: Neuroimmunology Core


PI_NAMEs: COSENTINO, STEPHANIE ANN (contact)

PROJECT_TERMS: Advocacy;Affect;aging brain;Ally;Alzheimer's Disease;Alzheimer's disease related dementia;Bioinformatics;Biological Markers;Body System;career;Clinical;Clinical Research;college;Complement;Complex;Data Science;Dementia;Dentistry;Development Plans;Discipline of Nursing;Disease;disease model;Education;education planning;education research;Engineering;Environmental Risk Factor;Epidemiology;experience;Face;Functional disorder;Future;Genetic;Goals;Grant;Health;innovation;insight;Institution;Knowledge;Laboratory Research;Light;Literature;Medical center;Medicine;Memory Loss;Mentorship;Methodology;multidisciplinary;Nervous System Disorder;Neurologist;Neurology;neuropathology;Neurosciences;next generation;novel;Pathway interactions;Physical therapy;Physicians;programs;Public Health;Research;Research Infrastructure;Research Institute;Research Methodology;Research Personnel;Research Project Grants;skills;Structure;Surgeon;Training;Training Programs;translational scientist;Underrepresented Minority;Universities

PROJECT_TITLE: Research Education Core


ADMINISTERING_IC: GM

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Clinical Research;Health Services;Immunization;Networking and Information Technology R&D (NITRD);Prevention;Primary Health Care;Vaccine Related

ORG_CITY: CLEMSON

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: CLEMSON UNIVERSITY

ORG_STATE: SC

PHR: Project narrative The proposed investigation will develop publicly accessible, reusable, upper-level clinical decision support (CDS) ontology and machine-interpretable CDS rules for CDC-recommended immunization schedules, which will save duplicate effort by multiple stakeholders of CDS rules and build a critical foundation for achieving interoperability for individuals’ immunization records. Our investigation also aims to enable primary care providers, especially in small primary care practices, to manage and maintain CDS rules independently to keep CDS updated, useful, and working to its full potential and to benefit the large population served by such practices. This investigation has the potential to provide more consistent preventive services and improve CDC-recommended immunization rates in primary care settings.

PI_NAMEs: JING, XIA  (contact)

PROGRAM_OFFICER_NAME: NGUYEN, HAN

PROJECT_TERMS: Adopted;Adoption;aged;Articulation;Behavior;care systems;Centers for Disease Control and Prevention (U.S.);Cessation of life;Child;Clinical;clinical decision support;Communicable Diseases;computer based Semantic Analysis;Development;Drug Interactions;Electronic Health Record;electronic health record system;Evaluation;experience;Extensible Markup Language;Foundations;Goals;Health;health care service;Hospitals;Immunization;Immunization Schedule;improved;Individual;Inequality;Institution;Interdisciplinary Study;interoperability;Investigation;Knowledge;Literature;Maintenance;Measures;Medicine;Meta-Analysis;Monitor;National Institute of Allergy and Infectious Disease;Occupations;Office Visits;Ontology;operation;Output;Participant;Patients;Pharmaceutical Preparations;Phase;Physicians;Play;Population;portability;prevent;prevention service;Preventive care;Preventive service;Primary Care;primary care practice;primary care provider;primary care setting;Process;Recommendation;Records;Reporting;Resources;restraint;Role;Schedule;Site;skills;South Carolina;syntax;System;Technology;Texas;Time;Underserved Population;United States;Update;usability;Vaccine Research;Validation;Vendor;Virginia;Visit

PROJECT_TITLE: Development, validation, and application of a CDS ontology to facilitate CDS rules reuse, management, and maintenance in simulated primary care settings.

STUDY_SECTION: BCHI

STUDY_SECTION_NAME: Biomedical Computing and Health Informatics Study Section[BCHI]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative MiCDA promotes research on the demography of aging, focusing on issues related to (1) Enriching data infrastructure to advance breakthroughs in the demography of aging; (2) The changing demography of late-life disability and dementia and related family caregiving issues; (3) Life course determinants of health and wellbeing in later life and related disparities. Findings contribute to our understanding of the health and wellbeing of older adults in the aging US population and internationally.

PI_NAMEs: FREEDMAN, VICKI A. (contact)

PROGRAM_OFFICER_NAME: NGUYEN, EMERALD THAI HAN

PROJECT_TERMS: Advisory Committees;Aging;aging demography;aging related;Alzheimer's Disease;Appointment;Area;base;Behavioral;Biological;Capsicum;Classification;Cognitive;Collaborations;Collection;Data;Data Collection;data enclave;data infrastructure;Data Sources;Dementia;Demography;Development;disability;Disparity;Economics;Ensure;Environment;Faculty;family caregiving;Family Demographies;Funding;Genetic;Genetic Risk;Goals;Grant;Health;Health and Retirement Study;health determinants;Home;human old age (65+);improved;Infrastructure;innovation;Institution;Interdisciplinary Study;interest;International;late life;Lead;Life Cycle Stages;Link;Longitudinal Studies;Measurement;Measures;Medicine;meetings;member;Methods;Michigan;Minority;National Institute on Aging;older adult;panel study of income dynamics;Performance;Personal Satisfaction;Pilot Projects;Population;pro-aging;Process;Program Development;programs;Psychology;Public Health;Publications;Request for Proposals;Research;Research Infrastructure;Research Support;Schools;Secure;Shapes;Sister;skills;social;Social Sciences;Sociology;Strategic Planning;Strategic vision;Survey Methodology;Surveys;symposium;synergism;System;Talents;Teacher Professional Development;trend;Universities;virtual;Writing

PROJECT_TITLE: Michigan Center on the Demography of Aging


NIH_SPENDING_CATS: Aging

PROJECT_TERMS: Aging;aging demography;aging population;data enclave;Event;Funding;Goals;Grant;interest;meetings;Michigan;Monitor;outreach;Pilot Projects;Process;Program Development;programs;Research Personnel;Research Support;Schools;Secure;Services;Strategic Planning;Strategic vision;symposium;Teacher Professional Development;Travel;Universities

PROJECT_TITLE: Administrative and Research Support Core


NIH_SPENDING_CATS: Aging;Burden of Illness;Clinical Research

PROJECT_TERMS: aging demography;Applications Grants;Appointment;Arts;Award;career;career development;Cohort Studies;Collaborations;college;Communities;Data;data infrastructure;data resource;Dementia;Demography;design;Development;disability;Disparity;Educational workshop;experience;Faculty;family caregiving;Feedback;Funding;Goals;Grant;health determinants;Institution;interest;late life;Life Cycle Stages;Literature;medical schools;meetings;member;Mentors;Michigan;Outcome;Paper;Personal Satisfaction;Pilot Projects;population based;Positioning Attribute;Process;Program Development;Program Research Project Grants;programs;Protocols documentation;Public Health;Research;Science;social;social science research;symposium;Teacher Professional Development;Time;Work

PROJECT_TITLE: Program Development (Pilot) Core


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Physical Injury - Accidents and Adverse Effects

ORG_CITY: DAYTON

ORG_DEPT: PHARMACOLOGY

ORG_NAME: WRIGHT STATE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative The threats to chemical warfare-associated agents are increasing consistently, yet there is no direct antidote available, thus an understanding of detailed molecular mechanisms is important to mitigate its local and systemic toxic effects. This project applies multiple well-established techniques and approaches at cellular, tissue and molecular levels to investigate the involvement of the lipid mediator Platelet-activating factor and microvesicle particles (MVP) release in chemical warfare-associated agents-induced deleterious effects. These studies will define the exact mechanism and develop novel treatment approaches to mitigate chemical warfare-associated agents’ induced local and systemic toxic responses.

PI_NAMEs: SAHU, RAVI PRAKASH;TRAVERS, JEFFREY B. (contact)

PROGRAM_OFFICER_NAME: KOCH, PETER

PROJECT_TERMS: acid sphingomyelinase;Address;Agonist;Alkylating Agents;antagonist;Antidotes;Antineoplastic Agents;Antioxidants;Applications Grants;Arsenicals;Binding;Body System;Burn injury;cell injury;Cell Line;Cells;chemical threat;Chemical Warfare;Chemicals;chemotherapeutic agent;chemotherapy;cigarette smoke;Cisplatin;Coupled;Cutaneous;cytokine;Cytoplasm;cytotoxic;Dacarbazine;Development;Dose;Enzymes;Epithelial Cells;Ethanol;Etoposide;Exposure to;Functional disorder;gemcitabine;Generations;Genetic;genetic approach;Goals;Human;Immunosuppression;In Vitro;in vivo;Inflammation;Inflammatory Response;inhibitor;Injury;insight;Ionizing radiation;keratinocyte;Knockout Mice;Knowledge;Laboratories;lipid mediator;Mechlorethamine;Mediating;Melphalan;Membrane;microvesicles;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;Mustard Gas;Nitrogen;novel;novel strategies;Nuclear;Null Lymphocytes;Organ;Outcome;Oxides;oxidized lipid;particle;Pathology;Pathway interactions;pharmacologic;Pilot Projects;Platelet Activating Factor;platelet activating factor receptor;Platelet Inhibitors;Pre-Clinical Model;prevent;Process;Production;PUVA Photochemotherapy;Reactive Oxygen Species;Receptor Signaling;response;Role;Signal Pathway;Signal Transduction;Site;Skin;Skin injury;Stimulus;stressor;systemic toxicity;Techniques;Testing;Therapeutic;Tissues;tool;Toxic effect;toxicant;Toxicant exposure;Translating;transmission process;Travel;Ultraviolet B Radiation;UVB induced;Vesicants;Vesicle

PROJECT_TITLE: Oxidized lipids and microvesicle particles as effectors for chemical threats to skin


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Burden of Illness;Caregiving Research;Dementia;Disability Research

PI_NAMEs: SCHOENI, ROBERT F (contact)

PROJECT_TERMS: 15 year old;Acceleration;Address;Affect;Aging;aging demography;aging population;aging related;Agreement;Area;career;Cognition;Collaborations;Collection;Country;Data;Data Collection;Data Set;Dementia;dementia caregiving;Demographer;Demography;design;Development;disability;experience;Family;Family Caregiver;family caregiving;Family Demographies;Family Study;Funding;Genetic;Genetic Materials;Goals;Grant;Home;human old age (65+);innovation;Institution;interest;International;Journals;Lead;Longitudinal Studies;Longitudinal Surveys;Measurement;meetings;member;Michigan;older adult;Personal Satisfaction;Pilot Projects;Population;Positioning Attribute;Process;Publications;Research;Research Design;Research Personnel;Resource Sharing;Running;Sister;social;Social Sciences;Survey Methodology;Surveys;symposium;Time;Time trend;trend;Washington;Work

PROJECT_TITLE: External Innovative Network Core


NIH_SPENDING_CATS: Aging;Networking and Information Technology R&D (NITRD)

PI_NAMEs: LEVY, HELEN G (contact)

PROJECT_TERMS: Address;aging demography;aging related;Awareness;base;Charge;Collaborations;Communities;Coupled;Data;data access;data enclave;Data Files;Diagnosis;Disclosure;Ensure;Environment;Face;Funding;Geography;Goals;Growth;Health and Retirement Study;High Performance Computing;Institution;Location;Michigan;panel study of income dynamics;Performance;prevent;Process;rapid growth;Reporting;Research;Research Personnel;Resources;Secure;Services;software infrastructure;success;System;virtual;web app

PROJECT_TITLE: Remote Data Enclave Core


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Diabetes;Wound Healing and Care

ORG_CITY: SAINT LOUIS

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative: Non-healing chronic wound is a major complication of diabetes that can lead to amputation. There is a clinical need for new and more effective treatments for diabetic wounds. Accomplishment of the proposed research will create a new generation of wound dressings capable of efficiently addressing the key hurdles for diabetic wounds to heal, leading to accelerated diabetic wound healing under young and aged conditions.

PI_NAMEs: GUAN, JIANJUN  (contact)

PROGRAM_OFFICER_NAME: LI, YAN

PROJECT_TERMS: Acceleration;Address;Affect;Affinity;aged;Aging;Amputation;angiogenesis;Attenuated;Binding;Biodistribution;biomaterial compatibility;cell motility;Cell Physiology;Cell secretion;Cell Survival;cell type;Chronic;chronic wound;Clinical;Collagen;Complications of Diabetes Mellitus;cytokine;density;Development;Diabetes Mellitus;Diabetic mouse;diabetic ulcer;diabetic wound healing;Dose;effective therapy;Endothelial Cells;Endothelium;Excision;Fibroblasts;Generations;Glucose;Goals;healing;Hydrogels;Impairment;improved;In Vitro;in vivo;Inflammation;Inflammatory;inhibitor;Injectable;innovation;keratinocyte;limb amputation;Lower Extremity;Macrophage;migration;monocyte;Myofibroblast;p38 Mitogen Activated Protein Kinase;Pathway interactions;Peptides;Persons;preservation;Principal Investigator;programs;Reactive Oxygen Species;receptor;regenerative;Research;Signal Transduction;Skin;Skin Abnormalities;Splint Device;Sterile coverings;Tensile Strength;Testing;Tissues;Topical application;Toxic effect;Transforming Growth Factor beta;wound;wound closure;wound dressing;wound healing

PROJECT_TITLE: Regenerative wound dressings for accelerating diabetic wound healing

STUDY_SECTION: MTE

STUDY_SECTION_NAME: Musculoskeletal Tissue Engineering Study Section[MTE]


NIH_SPENDING_CATS: Diabetes;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: TUCSON

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: Project Narrative Recent studies in diabetic humans and animal models have shown that retinal function decreases before the blood vessel problems of late-stage diabetic retinopathy begin, but the mechanisms of this retinal neuronal damage are not yet understood. We determine if changes in dopamine and Ca2+ signaling in the inner retina are responsible for these retinal functional changes, using electrical recordings of neural activity in response to physiological stimulation and neuronal labeling. This will test specific neuronal mechanisms that could serve as treatment targets to prevent the neuronal progression of diabetic retinal dysfunction.

PI_NAMEs: EGGERS, ERIKA D. (contact)

PROJECT_TERMS: Address;Affect;Amacrine Cells;Anatomy;Animal Model;Blindness;Blood Vessels;Brain;Buffers;Cell Death;Cells;Complement;Contrast Sensitivity;Development;Diabetes Mellitus;diabetic;diabetic patient;Diabetic Retinopathy;Disease;Dopamine;Dopamine Receptor;Electrophysiology (science);Electroretinography;Functional disorder;Future;gamma-Aminobutyric Acid;ganglion cell;Gene Modified;Goals;Grant;human model;In Situ Hybridization;In Vitro;Individual;Knowledge;Label;Light;Light Adaptations;Measurement;Measures;Mediating;mouse model;neural;Neurons;neurotransmission;optogenetics;Output;Pathway interactions;Physiological;prevent;receptor;receptor expression;receptor sensitivity;response;Retina;retinal adaptation;retinal damage;retinal neuron;retinal rods;Rod;Role;Signal Pathway;Signal Transduction;Stimulus;Streptozocin;targeted treatment;Testing;Time;Vertebrate Photoreceptors;Vision;Visual;Work

PROJECT_TITLE: Retinal Neuronal Signaling in Early Diabetes

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Genetics;Mental Health;Neurodegenerative;Neurosciences;Prevention;Social Determinants of Health

ORG_CITY: Los Angeles

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: NARRATIVE We launch the India ENIGMA Initiative for Global Aging & Mental Health - a globally coordinated study of brain aging and Alzheimer's disease (AD). Our overall goal is to identify predictive markers in the blood, genome, and epigenome, and psychosocial/lifestyle factors that influence brain aging in India, to better understand prognosis, and to support personalized risk evaluations on each continent. We plan to identify etiological pathways to resilience using the rich biobanking strategy developed by our partners at NIMHANS in India.

PI_NAMEs: GANESAN, VENKATASUBRAMANIAN ;JOHN, JOHN P;THOMPSON, PAUL M (contact)

PROGRAM_OFFICER_NAME: WAGSTER, MOLLY V

PROJECT_TERMS: Affect;Age;Aging;aging brain;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease risk;apolipoprotein E-4;Attention;biobank;biological sex;Biometry;Blood;Brain;brain research;California;cardiovascular risk factor;Caucasians;Clinical;Clinical Data;clinical predictors;Clinical Research;cohort;cost effective;Data;data harmonization;Dementia;design;Developing Countries;Diet;Diffusion Magnetic Resonance Imaging;Disease;disorder risk;DNA Methylation;Drug abuse;Drug usage;Education;Educational process of instructing;Educational workshop;empowerment;Endocrine;epigenetic marker;epigenome;Equation;Estrogens;ethnic diversity;Ethnic Population;Etiology;European;Evaluation;family support;Functional Magnetic Resonance Imaging;Future;Genetic;Genetic Risk;Genetic study;Genome;Genotype;global health;Goals;Grant;Health;High Density Lipoprotein Cholesterol;Hydrocortisone;Image;imaging biomarker;Impaired cognition;Incidence;India;Individual;Individual Differences;Inflammatory;Infrastructure;innovation;insight;Interleukin-6;International;international partnership;Journals;LDL Cholesterol Lipoproteins;life span;lifestyle factors;Link;literacy;low and middle-income countries;machine learning method;Magnetic Resonance Imaging;Measures;Medical;Medical Research;Mental Depression;Mental Health;methylation pattern;Modeling;Multimodal Imaging;multimodal neuroimaging;National Institute of Mental Health;Nervous System Disorder;neuroimaging;Neurosciences;novel;Pathway interactions;Peer Review;Persons;Pharmaceutical Preparations;Phenotype;Physical activity;Plasma;Population;predictive marker;predictive modeling;Process;Productivity;Prognosis;promote resilience;Proteomics;psychosocial;Psychosocial Factor;Publishing;Quality Control;Reproducibility;Research;Research Infrastructure;Research Personnel;resilience;resilience in aging;Resources;response;Rest;Risk;Rural;Science;Scientist;sex;Sleep;specific biomarkers;sulfated glycoprotein 2;tau Proteins;Techniques;Testing;Thyroid Gland;TNF gene;tool;Training;treatment trial;Triglycerides;United States National Institutes of Health;Universities;urban area


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: ROCHESTER

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: Project Narrative Neurological and neurodevelopmental disorders, such as autism and schizophrenia, have been suggested to involve deficits in perception related to how top-down cognitive processes, such as selective attention or expectations, modulate sensory processing. The proposed work will have a broad long-term impact on our understanding of these deficits by allowing us to examine how sensory expectations influence processing at the level of cortical circuits during active perception tasks. We will perform these experiments in a small New World primate, the common marmoset, a novel animal model which offers opportunities to study genetic models of human disease and to use advanced neurophysiological and molecular tools that were previously only available in rodent models.

PI_NAMEs: MITCHELL, JUDE F (contact)

PROGRAM_OFFICER_NAME: FLANDERS, MARTHA C

PROJECT_TERMS: Address;Animal Model;Animals;Area;area MT;area striata;area V1;Attention;attentional modulation;autism spectrum disorder;Behavior;Callithrix;Callithrix jacchus jacchus;Code;cognitive process;Complex;Cues;density;Evaluation;Exhibits;expectation;experimental study;Eye;Eye Movements;feature selection;fovea centralis;functional magnetic resonance imaging/electroencephalography;Genetic study;Human;human disease;human model;Image;Impairment;improved;Link;Location;Maps;Measures;Methods;Modeling;Molecular;Monkeys;Motion;Motor;Nervous System Disorder;neural;neural circuit;Neurodevelopmental Disorder;neuromechanism;Neurons;neurophysiology;Noise;novel;optogenetics;Parietal;Perception;Peripheral;Population;Primates;Property;rapid eye movement;receptive field;Research;Resolution;response;Rodent Model;Role;Saccades;Sampling;Schizophrenia;selective attention;Sensory;sensory cortex;Silicon;Slide;Stimulus;Surface;Testing;Time;tool;virtual;Vision;Visual;Visual Acuity;Visual Cortex;visual information;Visual Perception;visual processing;Work

PROJECT_TITLE: Neural basis of trans-saccadic perception

STUDY_SECTION: SPC

STUDY_SECTION_NAME: Mechanisms of Sensory, Perceptual, and Cognitive Processes Study Section[SPC]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: CHARLESTON

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

PHR: NARRATIVE Currently about 6 million Americans are affected by Alzheimer’s disease, a debilitating brain disorder manifested by declining cognitive skills. In this project we will generate novel strains of mice to test how a specific enzyme involved in lipid signaling affects the brain in Alzheimer’s disease models. These models are anticipated to provide novel insight into future development of therapies that reduce disease progression.

PI_NAMEs: VOELKEL-JOHNSON, CHRISTINA  (contact)

PROGRAM_OFFICER_NAME: DIBATTISTA, AMANDA

PROJECT_TERMS: Acids;Adipocytes;Affect;Aging;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease patient;American;amyloid peptide;angiogenesis;Animal Model;Animals;Astrocytes;Behavior;Brain;Brain Diseases;brain tissue;burden of illness;Cell Aging;Cell Death;Cells;Cellular biology;Ceramides;Clinic;cognitive function;cognitive skill;combat;Complex;conditioned fear;cost;Cost of Illness;Dementia;dementia risk;Development;Diagnosis;Disease;disease model;Disease Progression;Endothelial Cells;enzyme activity;Enzymes;Excision;exosome;Family;Farber's lipogranulomatosis;Functional disorder;Future;galactosylgalactosylglucosylceramidase;Growth;Healthcare Systems;Hydrolysis;Impaired cognition;Impairment;improved;Inflammation;insight;Knock-out;Knockout Mice;lipid I;Lipids;liquid chromatography mass spectrometry;Memory;Memory impairment;Metabolism;Microglia;migration;Modeling;Mouse Strains;Mus;Nerve Degeneration;Neurofibrillary Tangles;neuroinflammation;Neuronal Dysfunction;Neurons;neuropathology;Neuropathy;normal aging;novel;novel therapeutic intervention;object recognition;Pathology;Patients;Persons;Phosphotransferases;Proliferating;Reaction;Reporting;Role;senescence;senescent cell;senolytics;Signal Pathway;Signal Transduction;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;Sphingolipids;Sphingosine;sphingosine 1-phosphate;Stress;tau Proteins;Testing;therapeutic development;therapy development;United States;Vertebral column

PROJECT_TITLE: Acid Ceramidase in Alzheimers Disease

STUDY_SECTION: CDIN

STUDY_SECTION_NAME: Chronic Dysfunction and Integrative Neurodegeneration Study Section[CDIN]


NIH_SPENDING_CATS: Kidney Disease

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: NARRATIVE In order to bring new ideas into kidney disease to help our patients we need to get young and talented non- biology students interested in kidney medicine; so that they can creatively use their tools and training, to develop new treatments for kidney disease. This will be the focus of this R-25 Research Education Program.

PI_NAMEs: DINGEMANS, THEO ;GALLIPPI, CATERINA M;HOGAN, SUSAN LYNN;ROY-CHAUDHURY, PRABIR  (contact);SANKAR, JAGANNATHAN

PROGRAM_OFFICER_NAME: MARIC-BILKAN, CHRISTINE

PROJECT_TERMS: Address;Adult;Agriculture;American;Area;Biological Markers;Biomedical Engineering;Blood Vessels;Businesses;career;Caring;Cause of Death;Chemistry;Clinical;Clinical Data;cohort;cost;course development;Creativeness;Data Science;Dedications;Development;Diagnostic;Dialysis procedure;Disease;Disparity;disparity reduction;Ecosystem;education research;End stage renal failure;Entrepreneurship;Evaluation;experience;Faculty;Feedback;Future;Gills;Goals;Health;Health Care Research;Hemodialysis;Hour;ideation;Immersion;Incubators;Individual;innovation;innovative technologies;Institution;interdisciplinary approach;interest;Investments;Joints;Kidney;Kidney Diseases;lectures;Mathematics;Medicine;Membrane;Mentors;Mentorship;multidisciplinary;North Carolina;novel;Outcome;Pathway interactions;Patient Care;patient oriented;Patients;personalized care;Persons;Problem Solving;product development;programs;Public Health;Public Health Schools;Regulation;Research;Research Project Grants;Schools;skill acquisition;social media;Students;Talents;technological innovation;Technology;Therapeutic;Time;tool;Training;Training Activity;Training Programs;Transplantation;undergraduate student;Universities;Visit;Work;Workforce Development

PROJECT_TITLE: Transforming Kidney Care through Skill and Workforce Development: the North Carolina Kidney Technology Incubator (NC-KTI)

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: HEIDELBERG

ORG_COUNTRY: GERMANY

ORG_FIPS: GM

ORG_NAME: EUROPEAN MOLECULAR BIOLOGY LABORATORY

PHR: Project Narrative The GENCODE project produces reference genome annotation for the human and mouse genomes. The annotation provides a reference from which to conduct clinical and genomics research in the short term; in the long term it informs all research that will contribute fundamental knowledge to benefit public health.

PI_NAMEs: MARTIN, FERGAL JAMES (contact)

PROGRAM_OFFICER_NAME: GILCHRIST, DANIEL A

PROJECT_TERMS: Algorithms;Alternative Splicing;Automated Annotation;Biological;Biological Assay;Biological Models;Biomedical Research;Cells;Classification;Clinical;Code;Collaborations;Communication;Communities;community engagement;computational pipelines;Computing Methodologies;Data;Data Set;Databases;Development;Disease;Distal;Enhancers;Ensure;Excision;Exons;Feedback;Foundations;functional genomics;Future;Genes;Genetic Transcription;Genome;genome annotation;genome browser;genome-wide;Genomics;Goals;Graph;Haplotypes;Health;Human;human disease;Human Genome;improved;Knowledge;Lead;loss of function;Machine Learning;machine learning method;machine learning model;Manuals;Methods;model organism;Modeling;mouse genome;Mouse Protein;Mus;novel;Nucleic Acid Regulatory Sequences;Open Reading Frames;Output;outreach;Performance;Phenotype;Pilot Projects;Play;Population;Process;promoter;Protein Isoforms;Proteins;Protocols documentation;Pseudogenes;Public Health;reference genome;Regulatory Element;Reporting;Research;Resources;Rest;RNA Splicing;Role;Series;Site;Small RNA;Specificity;Technology;Tissues;tool;Training;Transcript;transcriptome;transcriptome sequencing;transcriptomics;Untranslated Regions;Untranslated RNA;Update;Variant;web site

PROJECT_TITLE: GENCODE: comprehensive reference genome annotation for human and mouse

STUDY_SECTION: GNOM

STUDY_SECTION_NAME: Genome Research Study Section[GNOM-G]


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Digestive Diseases;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Inflammatory Bowel Disease;Microbiome;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: ATLANTA

ORG_DEPT: PEDIATRICS

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE African Americans (AA) are disproportionately affected by inflammatory bowel disease (IBD) and this project aims to better define the basis of this disparity. We will investigate how the microbiome, epigenome, and metabolome of the ileal and rectal mucosa are related to the genetics and environment to culminate in more severe IBD onset and progression in these individuals. The combinatorial approach with multi-omic analysis and polygenic risk score assessment will give new insights to IBD mechanisms affecting AA and shed new light on potential markers/indexes for diagnosis and therapeutic strategies.

PI_NAMEs: KUGATHASAN, SUBRA  (contact)

PROGRAM_OFFICER_NAME: SHEA-DONOHUE, TEREZ

PROJECT_TERMS: Address;adverse outcome;Affect;African;African American;African American population;African ancestry;Alcohol consumption;Area;Automobile Driving;bead chip;Biopsy;Body mass index;Butyrates;Cell Physiology;cohort;Collection;combinatorial;community engagement;Consent;Crohn's disease;Data;Development;Diagnosis;Diet;Discipline;Disease;Disease Outcome;Disease Progression;Disparity;DNA;DNA Methylation;Environment;Environmental Risk Factor;Epigenetic Process;epigenome;Epithelial Cells;Epithelium;Ethnic Origin;European;European ancestry;experience;Fibroblasts;follow-up;Funding;gene discovery;Gene Expression;Gene Frequency;Genetic;genetic architecture;Genetic Research;Genomic DNA;Genomics;gut dysbiosis;gut microbiome;health disparity;Histologic;Human;ileum;Immune;immune function;indexing;Individual;Inflammatory;Inflammatory Bowel Diseases;innovation;insight;Intestines;Investigation;Life Style;Mediator;Mendelian randomization;Metabolic;metabolic profile;metabolome;metabolomics;Methods;Methylation;methylation pattern;microbial;microbiome;Mucous Membrane;multiple omics;Online Systems;Onset of illness;Organoids;Outcome;Pathway interactions;Patient Recruitments;Patients;polygenic risk score;programs;Publishing;recruit;rectal mucosa;Rectum;Research;research study;Resources;response;Risk;Risk Assessment;Role;Rural;Salivary;Sample Size;Sampling;Severity of illness;single-cell RNA sequencing;Smoking;stool sample;Testing;Therapeutic;Time;TNF gene;Underrepresented Populations;Up-Regulation;Validation

PROJECT_TITLE: Integrative multi-omic risk assessment at diagnosis and during disease progression in African-Americans with Inflammatory bowel disease


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Genetic Testing;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Human Genome;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases;Telehealth;Women's Health Research

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: PROJECT NARRATIVE The objective of this study is to develop, test, and evaluate a linguistically and culturally appropriate mainstreaming model for hereditary cancer multigene panel testing among cancer patients diverse in race/ethnicity, language, and education. This project would make a major contribution by transforming genetic counseling and testing practice, and promote effective risk communication, decision making, and more equitable delivery of genomic medicine to those at risk of hereditary cancer syndromes.

PI_NAMEs: HAMILTON, JADA GABRIELLE (contact)

PROGRAM_OFFICER_NAME: BURNETT, ANDREA NICOLE

PROJECT_TERMS: Address;Adopted;Behavior;behavioral outcome;behavioral response;Black race;brca gene;Cancer Center;Cancer Patient;cancer risk;cancer therapy;cascade genetic testing;Characteristics;Classification;Clinic;Clinic Visits;Clinical;cognitive interview;Communication;Community Hospitals;Comprehension;Consultations;County Hospitals;Decision Making;Diagnosis;Disclosure;Disparity;Distress;Education;Educational Materials;empowerment;Equity;ethnic diversity;Ethnic Origin;Evaluation;experimental study;Family;Future;Genetic;Genetic Counseling;genetic counselor;genetic panel test;Genetic Risk;genetic testing;Genetic Transformation;genetic variant;Genomic medicine;Germ Lines;Haitian;health literacy;Health Personnel;Hereditary Malignant Neoplasm;Hereditary Neoplastic Syndromes;hereditary risk;high school;improved;Intervention;Knowledge;Language;Latino;Learning;Linguistics;literacy;Mainstreaming;Malignant Breast Neoplasm;Malignant neoplasm of ovary;Malignant neoplasm of pancreas;Malignant neoplasm of prostate;Malignant Neoplasms;Medical;Medical Oncology;medically underserved;Memorial Sloan-Kettering Cancer Center;Methods;Minority;Modeling;non-genetic;Oncologist;Outcome;Pamphlets;Pathogenicity;patient population;Patients;Population Heterogeneity;Predisposition;primary outcome;prospective;psychosocial;psychosocial outcome;Race;racial diversity;Randomized;randomized, clinical trials;Recommendation;Research;Research Design;Research Methodology;response;Risk;Risk Assessment;Risk Management;satisfaction;sex;Site;Spanish;standard of care;telegenetics;Telephone;Test Result;Testing;testing uptake;Time;treatment choice;Update;uptake;Variant;variant of unknown significance;Videoconferencing

PROJECT_TITLE: The IMproving Access to Genetic INformation for Everyone (IMAGINE) Study: A Prospective Trial of a Mainstreaming Model for Hereditary Cancer Multigene Panel Testing Among Cancer Patients


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Precision Medicine;Prevention;Social Determinants of Health

ORG_DEPT: MISCELLANEOUS

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: Project Narrative Massive observational cohorts with the exposome (ie, multiple environmental factors) and phenome (disease risk factors) are being assembled by countries worldwide. We will equip the biomedical community with data science and machine learning tools for robust data-driven imputation, discovery, interpretation, and re-use of complex exposure-phenotype associations that emerge from big data. Applications of our methods will address several high-priority goals for the National Institutes of Environmental Health Sciences (NIEHS) including identification of environmental health disparities in heart disease that are critical for precision medicine implementation.

PI_NAMEs: MANRAI, ARJUN KUMAR;PATEL, CHIRAG J. (contact)

PROGRAM_OFFICER_NAME: DUNCAN, CHRISTOPHER GENTRY

PROJECT_TERMS: Address;All of Us Research Program;analytical method;Big Data;biobank;Biological;Biological Factors;Biological Markers;Cardiology;Catalogs;cohort;Cohort Studies;Communities;Complex;Country;Data;data resource;Data Science;Data Set;deep learning;Demographic Factors;Deposition;Diabetes Mellitus;Diet and Nutrition;Disadvantaged;Disease;disease disparity;disease phenotype;disorder risk;Disparity;Environment;Environmental Exposure;environmental health disparity;Environmental Risk Factor;Epidemiology;Etiology;Exhibits;feature selection;genetic risk factor;Goals;Health;health difference;health disparity;Heart Diseases;Human;hypercholesterolemia;Incidence;Lead;Libraries;Link;Literature;Machine Learning;machine learning method;Malignant Neoplasms;Measurement;Measures;Meta-Analysis;Metadata;Methods;Modeling;National Health and Nutrition Examination Survey;National Institute of Environmental Health Sciences;novel;Observational Study;phenome;Phenotype;Pollution;Population;Population Heterogeneity;precision medicine;Process;Reproducibility;Research Design;Research Personnel;Resources;Risk Factors;Role;Sample Size;Sampling;scale up;Testing;Time;tool;Translations;United States National Institutes of Health;Variant;vibration

PROJECT_TITLE: Data science tools to identify robust exposure-phenotype associations for precision medicine

STUDY_SECTION: BDMA

STUDY_SECTION_NAME: Biodata Management and Analysis Study Section[BDMA]


NIH_SPENDING_CATS: Clinical Research;Genetics;Immunotherapy;Lung;Microbiome;Nutrition;Pulmonary Fibrosis;Rare Diseases

PHR: Project Narrative Idiopathic pulmonary fibrosis (IPF) results in progressive scarring of lung tissue, respiratory failure and death. The immune system plays a key role in IPF. Bacteria in the human gut (gut microbiome) regulate the immune system. This research plan will reveal the role of the gut microbiome in the progression of lung fibrosis.

PI_NAMEs: O'DWYER, DAVID NOEL (contact)

PROGRAM_OFFICER_NAME: GOMEZ, CHRISTIAN RENE

PROJECT_TERMS: 16S ribosomal RNA sequencing;Adoptive Transfer;Age;Anaerobic Bacteria;Animal Model;Antigen-Antibody Complex;Attenuated;Bacteria;Bifidobacterium;Biological;Cells;Cellular Immunity;Cessation of life;Chronic lung disease;Clinical;Clinical Research;Clinical Trials;Color;cytokine;Data;Diet Modification;Disease;Disease Progression;Environment;Experimental Models;fecal transplantation;Fibrosis;fibrotic lung;Flow Cytometry;Foundations;FOXP3 gene;Future;Genes;Genetic Transcription;Germ-Free;Gnotobiotic;gut microbiome;gut microbiota;Hospitalization;Host Defense;host microbiota;Human;idiopathic pulmonary fibrosis;IL17 gene;Immune;Immune system;Immunity;immunogenic;immunoregulation;improved;In Vitro;Inflammation;Interleukin-10;Intervention Trial;Knowledge;Leukocytes;Life;Link;Lung;Lung Diseases;lung injury;lung microbiome;lung microbiota;Machine Learning;Mediating;metabolomics;Metagenomics;microbiome;microbiome therapeutics;microbiota;Modeling;Molecular;mortality;mouse model;Mucous Membrane;Mus;novel;Outcome;outcome prediction;Participant;Pathogenesis;Patients;Phenotype;Play;Pre-Clinical Model;prebiotics;Precision therapeutics;Production;programs;Publishing;Pulmonary Fibrosis;Pulmonary Inflammation;Quality of life;Rag1 Mouse;Recording of previous events;Recurrence;Regulation;Regulatory T-Lymphocyte;repaired;Reproducibility;Research;Research Personnel;Respiratory Failure;response;Role;Sampling;Sampling Studies;Severity of illness;Shapes;Statistical Models;stool sample;Survivors;T cell response;T cell therapy;T-Lymphocyte;Testing;tool;transcriptional reprogramming;transcriptome sequencing;Transgenic Model;Transgenic Organisms;translational approach;Translational Research;translational study;treatment strategy;United States National Institutes of Health;Work

PROJECT_TITLE: Gut Microbiota and Host Regulatory Cross-Talk in Pulmonary Fibrosis


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Clinical Research;Immunization;Infectious Diseases;Prevention;Vaccine Related

ORG_NAME: ROCKEFELLER UNIVERSITY

PHR: PROJECT NARRATIVE B cells produce the antibodies that help us control infections and are the primary mechanism though which vaccines work. Although we understand well the general biology of B cells, the specific mechanisms by which antibodies evolve to become sufficiently potent to combat disease are not fully understood. The work proposed in this application will help us design vaccines that are better able to induce potent antibodies against pathogens such as influenza, HIV, and SARS-CoV2.

PI_NAMEs: VICTORA, GABRIEL D (contact)

PROGRAM_OFFICER_NAME: CASTLEMAN, MORIAH JOVITA

PROJECT_TERMS: 2019-nCoV;Address;Affinity;Antibodies;Antibody Affinity;Antibody-Producing Cells;antigen binding;Antigenic Specificity;Antigens;Autoimmune Diseases;B-Lymphocytes;Biological Assay;Biology;Biotin;Cell Communication;Cell model;Cells;clinically relevant;Clonal Expansion;Cloning;combat;Development;Disease;Engineering;Epitopes;Equilibrium;experimental study;Fine needle aspiration biopsy;follow-up;gain of function;Gene Expression Profile;Generations;Haptens;Helper-Inducer T-Lymphocyte;Hemagglutinin;HIV;Human;Hypersensitivity;Immunoglobulin Genes;Immunoglobulins;in vivo;Infection;Infection Control;Influenza;Injections;Investigation;Label;Link;lymph nodes;Measures;Memory B-Lymphocyte;Methods;Modality;Modeling;Mus;Mutation;novel;Outcome;Output;pathogen;peptide A;Peptides;Physiological;Population;Process;Proteins;Reagent;response;RNA vaccination;Role;single-cell RNA sequencing;Specificity;Structure of germinal center of lymph node;Surface;System;T-Lymphocyte;Testing;theories;TNFRSF5 gene;TNFSF5 gene;transcriptomics;Vaccination;Vaccine Design;Vaccines;Variant;Viral Antigens;Viral Proteins;Virion;Virus;Virus Diseases;Work

PROJECT_TITLE: Defining the role of T cell help in germinal centers by intercellular enzymatic labeling

STUDY_SECTION: CMIB

STUDY_SECTION_NAME: Cellular and Molecular Immunology - B Study Section[CMIB]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Urologic Diseases

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE The proposed research will sustain and expand a Summer Program in Undergraduate Urologic Research at the University of Wisconsin-Madison. Undergraduate Scholars from many disciplines will perform mentored research and engage in active exercises to understand urology from the physician, pharmacist, nurse, and veterinary practitioner perspectives. We expect to stimulate lifelong interest in a urology research career.

PI_NAMEs: PENNISTON, KRISTINA L;VEZINA, CHAD M. (contact)

PROJECT_TERMS: Active Learning;Address;Advocate;American;Anatomy;Area;Automobile Driving;Basic Science;Benign;Biomedical Research;career;career development;career networking;Clinical;clinical training;Color;Communities;community empowerment;Community Medicine;cost;cost outcomes;Country;Critical Thinking;Degree program;Development;Diagnostic;Discipline;Discipline of Nursing;Disease;Education;Education Projects;Educational Curriculum;Educational process of instructing;Ensure;Environment;evidence base;Exercise;experience;Exposure to;Face;Faculty;Fellowship Program;Future;Genitourinary system;graduate school;graduate student;hands on instruction;Hematology;improved;improved outcome;innovation;Institution;interest;Kidney;Learning;Learning Module;lecturer;Letters;Lower urinary tract;Manuscripts;matriculation;medical schools;meetings;member;Mentored Clinical Scientist Development Program;Mentors;Mind;Molecular;multidisciplinary;National Institute of Diabetes and Digestive and Kidney Diseases;Nurses;Outcome Measure;Pathologist;Patient Care;Patient Recruitments;peer;Peer Review;Pharmacists;Pharmacologic Substance;Pharmacy facility;Physicians;Population;Positioning Attribute;Problem Solving;Process;Productivity;Program Development;programs;prospective;Public Health;Publications;Quality of life;recruit;Research;Research Personnel;Research Training;Resources;responsible research conduct;Science;Scientist;Structure;student training;Students;success;summer program;Surgeon;surgery outcome;Training;Training and Education;Training Programs;undergraduate research experience;undergraduate student;Underrepresented Students;Universities;University resources;urinary;urologic;Urology;Veterinarians;Veterinary Medicine;virtual;Wisconsin;Work

PROJECT_TITLE: Summer Program in Undergraduate Urology Research (SPUUR)


NIH_SPENDING_CATS: Cancer;Cervical Cancer;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Health Services;Infectious Diseases;Prevention;Sexually Transmitted Infections;Women's Health Research

PHR: NARRATIVE Because many women living with HIV (WLWH) are also infected with human papillomavirus (HPV), the cause of cervical cancer, they have a very high likelihood of developing cervical cancer over their lifetime. In this project, we propose to implement a clinical site in Nairobi, Kenya at a high-volume HIV treatment clinic called the Coptic Hope Center for Infectious Diseases where clinical trials can be conducted and test interventions to improve cervical cancer screening and treatment for WLWH. At our site, we have the experience and expertise to study methods that can potentially increase the number of women getting screened, improve how women who test positive are managed, and better treat any disease that is detected.

PI_NAMEs: CHUNG, MICHAEL HOONBAE (contact);SAKR, SAMAH RAFIE

PROGRAM_OFFICER_NAME: FRECH, MARIA SILVINA

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Affect;Africa South of the Sahara;Age;anti-cancer research;antiretroviral therapy;barrier to care;base;Biopsy;burden of illness;cancer clinical trial;Cancer Control;Cancer Etiology;cancer prevention;cancer therapy;Capital;Caring;Centers for Disease Control and Prevention (U.S.);Cervical;Cervical Cancer Screening;Cervical Intraepithelial Neoplasia;Cessation of life;Cities;Clinic;Clinical;Clinical Research;clinical research site;Clinical Treatment;clinical trial implementation;Clinical Trials;Clinical Trials Network;clinically significant;Cold Therapy;Colposcopy;Communicable Diseases;Communities;Conduct Clinical Trials;Country;County;Cytology;Data;Disease;Education;Eligibility Determination;Emergency Situation;Enrollment;Excision;experience;Feasibility Studies;follow-up;Funding;Government;Guidelines;Health;Health Services Accessibility;High Prevalence;high risk;Histology;HIV;HIV Infections;Hospitals;HPV positive;Human papilloma virus infection;Human Papillomavirus;improved;Incidence;Infrastructure;insight;Intervention;Intervention Studies;Kenya;Laboratories;Lead;Leadership;Lesion;Location;loop electrosurgical excision procedure;low and middle-income countries;Malignant neoplasm of cervix uteri;Malignant Neoplasms;meetings;Methods;National Cancer Institute;Participant;Patient Recruitments;Persons;Plasma;premalignant;Prevalence;Prevention Research;Procedures;programs;protocol development;Randomized;randomized, clinical trials;Recommendation;recruit;Recurrence;Reporting;Research;response;screening;Screening for cancer;screening services;Site;synergism;Testing;treatment center;treatment services;Triage;uptake;Viral Load result;Woman;Women's mortality;women's prevention;women's treatment;World Health Organization

PROJECT_TITLE: HIV/cervical cancer cOntrol and Prevention clinical sitE in Kenya (HOPE-Kenya)


NIH_SPENDING_CATS: Nutrition;Obesity

ORG_CITY: IOWA CITY

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: PROJECT NARRATIVE: The proposed project is relevant to public health in that it is expected to reveal a novel molecular mechanism that underlies the ADH5-mediated brown fat immune-metabolic homeostasis in the context of obesity, and to thereby advance knowledge in the fields of obesity-associated metabolic dysfunction. Thus, the proposed research is relevant to the NIH mission of developing fundamental knowledge that will help to reduce the burdens of human disability.

PI_NAMEs: YANG, LING  (contact)

PROGRAM_OFFICER_NAME: LYNCH, CHRISTOPHER

PROJECT_TERMS: Adipose tissue;Adrenergic Agents;Aging;Alcohol dehydrogenase;Animal Model;biological adaptation to stress;Brown Fat;Cardiovascular Diseases;Cell Physiology;Chronic;Cues;Cysteine;Data;Defect;diet-induced obesity;disability;Disease;Down-Regulation;Equilibrium;Exposure to;feeding;Functional disorder;Glucose Intolerance;Goals;Health;heat-shock factor 1;Homeostasis;Human;human disease;human model;Immune;immune cell infiltrate;Impairment;improved;Inflammation;Inflammatory;insight;Knockout Mice;Knowledge;Laboratory Research;Link;Liver;Mammals;Mediating;Mediator;Metabolic;Metabolic dysfunction;Metabolic stress;Metabolism;Mission;Mitochondria;Mitochondrial Proteins;Molecular;Mus;Names;Nitric Oxide;nitrosative stress;novel;Nutrient;Obesity;Outcome;Overnutrition;oxidation;Oxidation-Reduction;Oxidoreductase;Pathogenesis;pharmacologic;Physiology;Play;Post-Translational Protein Processing;Production;Protein S;Proteins;Proteomics;proteostasis;Public Health;Reactive Nitrogen Species;Reactive Oxygen Species;Regulation;Research;Respiration;response;restoration;Role;S-Nitrosoglutathione;Signal Transduction;Skeletal Muscle;SKIL gene;Stimulus;Stress;stressor;Sulfhydryl Compounds;Testing;Therapeutic;therapeutic target;Thermogenesis;Tissues;transcription factor;uncoupling protein 1;United States National Institutes of Health

PROJECT_TITLE: Role of ADH5 in the Regulation of Brown Adipose Tissue Metabolic Homeostasis

STUDY_SECTION: POMD

STUDY_SECTION_NAME: Pathophysiology of Obesity and Metabolic Disease Study Section[POMD]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Hematology;Infectious Diseases;Prevention;Sepsis

ORG_CITY: SOLANA BEACH

ORG_NAME: NIGHTINGALE LABS CORPORATION

PHR: PROJECT NARRATIVE Sepsis is a costly and often fatal condition that results from spread of localized infections. In the hospital, early detection of sepsis makes it possible to start antibiotics sooner and improve outcomes; however, most sepsis begins outside of the hospital, in the home. This proposal aims to use sensors in the home bed to recognize early signs of infections and sepsis and to improve care.

PI_NAMEs: CHAN, RAYMOND C (contact)

PROGRAM_OFFICER_NAME: MINNICOZZI, MICHAEL

PROJECT_TERMS: actigraphy;Adherence;Admission activity;Antibiotics;antimicrobial;Automation;Beds;blind;Blood;Cardiopulmonary;Cardiopulmonary Physiology;Caring;Charge;Chronic Obstructive Pulmonary Disease;Clinic Visits;Clinical;Communication;Communities;Complex;Contracts;cost;dashboard;Data;data ingestion;Dehydration;design;Detection;detection platform;Devices;Diagnostic;Dialysis procedure;Early Diagnosis;Early Intervention;End stage renal failure;Enrollment;Evaluation;Event;feasibility testing;Focal Infection;Frequencies;Gastrointestinal Hemorrhage;Goals;Health system;Heart failure;Home;Home visitation;hospice environment;Hospital Costs;Hospitalization;Hospitals;Hour;improved;improved outcome;Infection;Intervention;Learning;Mattresses;Measures;Monitor;Morbidity - disease rate;mortality;Notification;observational cohort study;Observational Study;Outcome;Outpatients;Patient Participation;patient population;Patient Recruitments;Patients;Phase;Pneumonia;Population;population health;Process;prospective;recruit;Reporting;Research;response;Risk;sensor;Sepsis;Septic Shock;service organization;sleep pattern;Small Business Innovation Research Grant;Symptoms;Systemic infection;Technology;Testing;Thoracic Radiography;Travel;Urine;wearable device;Work

PROJECT_TITLE: Feasibility of early detection of infection and sepsis in the home

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HSS-J(10)B]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Prevention;Rare Diseases

ORG_CITY: STANFORD

ORG_DEPT: SURGERY

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative  Abdominal aortic aneurysm (AAA) disease is a common cause of premature death in adult Americans. No medical (non-surgical) management options exist to prevent disease progression. This project will determine whether metformin, a drug used for >60 years to manage diabetes worldwide, will prove safe and effective in limiting AAA enlargement in non-diabetic participants, and if so, ushering in an entirely new era of AAA management.

PI_NAMEs: DALMAN, RONALD L (contact);LU, YING ;MAHAFFEY, KENNETH W.

PROGRAM_OFFICER_NAME: REID, DIANE M

PROJECT_TERMS: Abdominal Aortic Aneurysm;Address;Adult;American;Analysis of Variance;Aneurysm;angiogenesis;Aortic Aneurysm;Biological Process;Blood specimen;Cardiovascular Diseases;Cardiovascular Manifestation;Cardiovascular system;Caring;Centrifugation;Cessation of life;Clinical Trials;Computerized Medical Record;Concurrent Review;cost;cost estimate;Data;diabetes management;Diabetes Mellitus;diabetic;diabetic patient;Diameter;Diet Modification;disability;Disease;Disease Management;Disease Progression;Dose;Drug usage;FRAP1 gene;gastrointestinal;Goals;Growth;Health Benefit;Hematology;Human Biology;human disease;Hypoglycemic Agents;Individual;Intervention;Location;Macrophage;Medical;Medical Records;Medicare;Metabolic;Metformin;Monitor;non-diabetic;novel;novel therapeutic intervention;Nuclear;Operative Surgical Procedures;Oral;Participant;Pathway interactions;Patients;Periodicals;Pharmaceutical Preparations;Physical Examination;Placebos;premature;Prevalence;prevent;primary endpoint;Production;programs;progression risk;prospective;prospective test;Protein Family;Public Health;Quality of life;Randomized;Reactive Oxygen Species;Recommendation;repaired;resilience;response;Retrospective Studies;Risk;Risk Reduction;Rupture;Ruptured Abdominal Aortic Aneurysm;Safety;safety assessment;screening;Source;Strategic vision;Stratification;Sudden Death;Surveys;Test Result;Testing;theories;Translational Research;treatment effect;United States National Institutes of Health;X-Ray Computed Tomography

PROJECT_TITLE: The LIMIting AAA with meTformin (LIMIT) Trial

STUDY_SECTION: SSPT

STUDY_SECTION_NAME: NHLBI Single-Site and Pilot Clinical Trials Study Section[SSPT(MA)]