NIH_SPENDING_CATS: Clinical Research;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Genetics;Human Genome;Prevention;Rare Diseases

PROJECT_TERMS: Adenitis;Affect;Alleles;Antigen-Presenting Cells;Aphthous Stomatitis;autoinflammatory diseases;Behcet Syndrome;Biological;Biological Assay;CCR1 gene;chemokine;Child;Childhood;Clinical;cohort;Complex;Disease;disease phenotype;disease-causing mutation;effective therapy;Family;Fever;Flare;Genes;genetic architecture;Genetic Diseases;genetic predictors;Genetic Predisposition to Disease;Genetic Risk;genome wide association study;Genomics;Health;Hospitals;IL12A gene;Immune;Immune system;Immunologics;Indiana;Individual;Inflammatory;Institutional Review Boards;Interferon Type II;Interferons;Interleukin-10;Interleukin-12;Link;lymphadenopathy;microorganism antigen;monocyte;Mosaicism;Oropharyngeal;Pathway interactions;Patient Recruitments;Patients;Penetrance;Periodicals;peripheral blood;Pharyngitis;polygenic risk score;Production;Protocols documentation;rare variant;Recurrence;Risk;risk variant;Role;Sampling;Site;STAT4 gene;Susceptibility Gene;Syndrome;T-Lymphocyte;Tonsillitis;Transcript;treatment response;Trisomy 8;Ulcer;United States National Institutes of Health;Universities;Up-Regulation;Variant

PROJECT_TITLE: Genetic susceptibility loci for PFAPA


ACTIVITY: ZIA

ADMINISTERING_IC: AI

ARRA_FUNDED: N

FUNDING_MECHANISM: INTRAMURAL RESEARCH

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;Genetics;Infectious Diseases;Lung;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

PI_NAMEs: DANG, ERIC  (contact)

PROJECT_TERMS: 25-hydroxycholesterol;Ablation;Address;Alveolar Macrophages;Antigen-Antibody Complex;Area;Asthma;Automobile Driving;Bacteria;Basophils;Biochemical;Biochemistry;Biological Assay;Biology;Bone Marrow;Bronchioles;CD4 Positive T Lymphocytes;Cell Differentiation process;Cells;Ceramide glucosyltransferase;chemical genetics;Chimera organism;Cholesterol;Chromatography;Circulation;Colon;Cryptococcus neoformans;Cryptococcus neoformans infection;cytokine;Cytokine Signaling;Data;Disease;Distal;Down-Regulation;Enzymes;eosinophil;Epithelial Cells;Eukaryota;experimental study;extracellular;Flow Cytometry;Food;fungal genetics;Fungal Proteins;fungus;G-Protein-Coupled Receptors;Genetic Screening;global health;Goals;Granuloma;Granulomatous;Growth;gut microbiota;health care settings;Iatrogenesis;Image;Immunity;Immunocompromised Host;Immunologics;In Vitro;Infection;Inflammation;Innate Immune Response;interest;Interferons;Interleukin-13;Interleukin-4;intestinal crypt;Intestines;Knock-in Mouse;Knock-out;Lamina Propria;latent infection;latent persistent infection;Ligands;Link;LoxP-flanked allele;Lung;Macrophage;Microscopy;Mixed Function Oxygenases;Modeling;mouse genetics;Mus;Mycoses;Oral;Organ;Organoids;Outcome;pathogen;pathogenic fungus;Pathway interactions;Peptide Hydrolases;Physiology;Positioning Attribute;prevent;Primary Infection;Process;Production;Protein Secretion;pulmonary granuloma;recruit;Refractory;Reporter;Research;response;Sensory;single-cell RNA sequencing;Site;Small Intestines;Source;stem cell differentiation;stem cells;Structure;Testing;Textbooks;Th2 Cells;Time;Tissues;Wild Type Mouse

PROJECT_TITLE: Investigating mammalian innate immune responses to pathogenic fungi


NIH_SPENDING_CATS: Aging;Genetics;HIV/AIDS;Infectious Diseases;Pediatric;Pediatric - AIDS;Women's Health Research

ORG_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

PI_NAMEs: GOODENOW, MAUREEN  (contact)

PROJECT_TERMS: Address;Adolescent Medicine Trials Network;Adult;Affinity;Age;Age Years;Antiinflammatory Effect;antiretroviral therapy;Apoptosis;Archives;B-Lymphocytes;Basic Science;biobank;Biodiversity;Biological Markers;Birth;Blood;Blood Cells;Blood Tests;Caring;Cell Communication;cell growth;Cell Physiology;cell type;Cells;Childhood;Chronic;Clinical;Clinical Data;Clinical Trials;Clonality;comorbidity;Complex;complex chronic conditions;Consequences of HIV;CXCL9 gene;design;Development;differential expression;disability;Disease Progression;DNA Repair;Educational workshop;Exposure to;Funding;Gender;Gene Expression;Gene Expression Profile;Genes;genome-wide;Germany;Goals;Health;Heterogeneity;HIV;HIV Infections;HIV-1;HIV-exposed uninfected infant;HIV/AIDS;Homeostasis;Immune;immune activation;Immune Plasma;Immune response;Immune system;Immunoglobulin Somatic Hypermutation;Immunoglobulins;Immunologic Markers;immunological status;immunoregulation;Individual;individual response;Infant;Infection;Inflammation;Inflammatory;inflammatory marker;innate immune pathways;insight;International;International AIDS;Intervention;Knowledge;Laboratories;Length;Libraries;Life;life span;Link;Long-Term Effects;Machine Learning;Macrophage;Marijuana;marijuana use;maternal imprint;Maternally-Acquired Immunity;Measures;men;Messenger RNA;Metabolic;metabolic profile;Metabolism;Methods;Molecular;Molecular Analysis;monocyte;Mothers;multiple omics;National Institute of Allergy and Infectious Disease;National Institute of Child Health and Human Development;Nepal;neuroAIDS;Neurocognition;Neurocognitive;Newborn Infant;novel;older adult;older men;older women;Opportunistic Infections;Oral;Outcome;Outcome Measure;oxidation;Paris, France;Participant;Pathogenesis;Pathway interactions;Pattern;peripheral blood;Persons;Plasma;Policies;Post-Translational Protein Processing;posters;PPAR alpha;Pregnancy;prenatal;Property;prospective;Protein Biosynthesis;Quality of life;random forest;Recreation;Regulation;Research;Research Priority;research study;Research Technics;Resources;response;Retroviridae Infections;Role;Sampling;secondary analysis;Shapes;Signal Pathway;Signal Transduction;Specimen;Structure of germinal center of lymph node;Subgroup;substance use;symposium;targeted treatment;Testing;therapy development;Tobacco;Tobacco use;Transcriptional Regulation;transcriptome;transcriptome sequencing;treatment strategy;Umbilical Cord Blood;United States National Institutes of Health;Up-Regulation;Viral;Viremia;Virus;Virus Diseases;virus host interaction;Washington;Woman;Yin;young man;young woman;Youth

PROJECT_TITLE: HIV-1 and host interactions at molecular level


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Coronaviruses;Emerging Infectious Diseases;Infectious Diseases;Prevention

PI_NAMEs: RICOTTA, EMILY  (contact)

PROJECT_TERMS: Adopted;Attention;Characteristics;Clinical;clinical decision support;clinical decision-making;clinical epidemiology;Clinical Research;Communicable Diseases;Community Health;Consensus;COVID-19 pandemic;Data;Data Collection;data collection methodology;data management;data mining;Data Sources;design;Development;Disease;disease natural history;Disease Outbreaks;Ebola;Educational workshop;Elements;Epidemic;Epidemiologist;epidemiology study;Ethicists;Ethics;flexibility;Funding;Future;global health;Goals;Health;Immune System Diseases;immunodeficiency;improved;Influenza A Virus, H1N1 Subtype;interest;Intervention;Legal;Libraries;Literature;Medical;Medicine;Methods;Morbidity - disease rate;Nature;novel;Outcome;pandemic preparedness;pandemic response;Policies;Population;Population Study;prevent pandemics;Protocols documentation;Public Health;public health emergency;Publications;Publishing;relative cost;Research;Research Design;response;Risk;Role;SARS coronavirus;Scientist;social;Speed;statistical and machine learning;Time;United States National Institutes of Health;Vaccines;Work;ZIKA

PROJECT_TITLE: The study and improvement of data collection and management for infectious diseases and immunodeficiencies


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Climate-Related Exposures and Conditions;Emerging Infectious Diseases;Infectious Diseases;Prevention

PROJECT_TERMS: Acceleration;Agriculture;Animal Diseases;Animals;Area;Attention;Award;Biodiversity;Catalogs;Climate;climate change;climate-related health;Collaborations;Communicable Diseases;Country;Data;Data Analyses;Data Collection;data management;data sharing;Databases;Detection;Development;Disease;Disease Outbreaks;Disease Surveillance;Emerging Communicable Diseases;Epidemic;epidemic response;Evaluation;Frequencies;Funding;global health;Grant;Health;Health Sciences;Healthcare;Human;human disease;improved;Infection;Information Systems;Investigation;lens;Maps;Modeling;National Institute of Environmental Health Sciences;open data;outbreak concern;outbreak prediction;outbreak response;pandemic preparedness;pandemic response;Pattern;Performance;Personnel Management;Policies;Politics;Postdoctoral Fellow;Preparation;pressure;programs;Proxy;Readiness;Recommendation;Regression Analysis;Reporting;Research;Research Personnel;Research Project Grants;response;Risk;Risk Assessment;Risk Factors;secondary analysis;Security;Time;Training;Travel;Universities;Vector-transmitted infectious disease;weapons;World Bank;Zoonoses

PROJECT_TITLE: Analysis of data management capacity in regions with high infectious disease spillover risk


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Genetics;Human Genome;Neurosciences;Pediatric;Primary Immunodeficiencies;Rare Diseases

PI_NAMEs: SAFAVI, FARINAZ  (contact)

PROJECT_TERMS: Address;autoinflammatory;bench to bedside;Biological Assay;Brain;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Central Nervous System;Cerebrospinal Fluid;Clinical;clinical center;Clinical Protocols;Collection;Color;congenital immunodeficiency;CRISPR/Cas technology;Defect;Development;Disease;early childhood;Electrophysiology (science);Engineering;Evaluation;Flow Cytometry;Gene Mutation;Genes;glial cell development;Goals;Immune;immune function;Immune System Diseases;Immunity;immunodeficiency;Immunophenotyping;immunoregulation;induced pluripotent stem cell;Induced pluripotent stem cell derived neurons;Infection;Institutional Review Boards;interest;Investigation;Methods;Molecular Biology;Morbidity - disease rate;Morphology;mortality;multiple omics;Mutation;Nervous System;Nervous System Disorder;Neuroglia;neuroinflammation;Neurologic;Neurologic Symptoms;Neurological observations;neuronal survival;Neurons;Neuropathogenesis;Organoids;patient derived induced pluripotent stem cells;Patients;Peripheral Blood Mononuclear Cell;Phenotype;programs;Protocols documentation;rare genetic disorder;recruit;Refractory;Research;Role;Sampling;Serum;single-cell RNA sequencing;Syndrome;System;Techniques;transcriptome;United States National Institutes of Health

PROJECT_TITLE: Neuropathogenesis of Errors of Immunity


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Nanotechnology;Pneumonia and Influenza;Prevention;Vaccine Related

PI_NAMEs: HARRIS, AUDRAY  (contact)

PROJECT_TERMS: 1918 influenza pandemic;3-Dimensional;Address;Adjuvant;Admixture;Affect;Animals;Antibodies;Antigenic Variation;Antigens;Architecture;Area;Attenuated;B-Lymphocytes;Biochemical;Biochemistry;Communicable Diseases;Competence;Complex;Coupled;cross reactivity;design;Development;Electron Microscopy;Epitopes;Evaluation;future pandemic;Goals;Health;Hemagglutinin;Human;Immune response;Immunity;Immunoassay;immunogenic;immunogenicity;Immunologics;Influenza;Influenza A virus;Influenza A Virus, H1N1 Subtype;Influenza A Virus, H7N9 Subtype;Influenza Hemagglutinin;influenza outbreak;influenza virus vaccine;influenzavirus;innovation;Investigation;Membrane Glycoproteins;Mission;Molecular;Molecular Conformation;molecular modeling;mosaic;nanotechnology platform;Nature;neutralizing antibody;pandemic disease;particle;Persons;Pharmaceutical Preparations;Phase;Population;Proteins;Public Health;Recombinants;Research;Seasons;Structure;Subunit Vaccines;Testing;transmission process;United States National Institutes of Health;universal influenza vaccine;vaccine formulation;Vaccine Production;Vaccines;Viral Vaccines;Virus;Virus-like particle;Work;Zoonoses

PROJECT_TITLE: Development of Broadly Immunogenic and Universal Influenza Virus Vaccines


NIH_SPENDING_CATS: Eczema / Atopic Dermatitis;Infectious Diseases;Microbiome

PI_NAMEs: GOUGH, PORTIA  (contact)

PROJECT_TERMS: Adhesions;Affect;Anti-Inflammatory Agents;anti-microbial peptide;Antiinflammatory Effect;antimicrobial;Atopic Dermatitis;Bacteria;Binding;Cell Death;Cell Death Induction;Cells;chemokine;Coculture Techniques;commensal bacteria;commensal microbes;CXCL10 gene;cytokine;Data;Data Analyses;Data Set;Detection;Disease;Eczema;Epithelial Cells;Evaluation;Fibroblasts;Goals;Health;Homeostasis;host-microbe interactions;Human;human data;IL18 gene;IL8 gene;Immune signaling;Immunologic Receptors;immunoregulation;In Vitro;in vitro Model;in vivo;Incubated;Infection;Infectious Skin Diseases;Inflammation;Inflammatory;Inflammatory Response;inhibitor;Innate Immune Response;interest;Investigation;IRAK3 gene;keratinocyte;Knockout Mice;Lesion;MAP Kinase Gene;MAPK3 gene;Mediating;Microbe;Modeling;Mucous Membrane;multiple omics;Mus;Natural Immunity;Nature;NF-kappa B;Organism;p38 Mitogen Activated Protein Kinase;pathobiont;pathogen;pathogenic bacteria;pathogenic microbe;Pathogenicity;Physiology;Production;Proteins;Proteobacteria;Proteomics;Receptors, Tumor Necrosis Factor, Type II;Research;response;Roseomonas;Signal Transduction;Site;Skin;Staphylococcus aureus;Systems Biology;Testing;Therapeutic;TLR2 gene;TLR5 gene;TNFRSF1B gene;Variant;Wild Type Mouse

PROJECT_TITLE: Mechanisms of host-commensal interactions with Roseomonas mucosa that modulate innate immune responses to infection with Staphylococcus aureus and support homeostasis of human skin


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Pneumonia and Influenza;Prevention;Vaccine Related

PI_NAMEs: TAUBENBERGER, JEFFERY  (contact)

PROJECT_TERMS: 1918 influenza pandemic;Antigenic Variation;Avian Influenza A Virus;B-Lymphocytes;Birds;Cessation of life;Clinical;clinical development;Clinical Research;comparison control;Control Animal;Country;Domestic Fowls;efficacy study;Epidemic;Experimental Animal Model;Family suidae;Ferrets;Goals;Hemagglutinin;Human;human pathogen;immunogenicity;Inactivated Vaccines;Infection;Inflammatory Response;Influenza;Influenza A virus;Influenza A Virus, H3N8 Subtype;Influenza A Virus, H5N1 Subtype;Influenza A Virus, H7N9 Subtype;influenza epidemic;influenza infection;influenza virus vaccine;influenzavirus;Intramuscular;Modeling;Morbidity - disease rate;mortality;Mus;Neuraminidase;new pandemic;novel;novel vaccines;pandemic disease;pandemic virus;Pathogenicity;Persons;Phase;prevent;previous pandemic;Public Health;Pulmonary Pathology;Reporting;Route;Safety;Spanish flu;T-Lymphocyte Epitopes;universal influenza vaccine;universal vaccine;Vaccinated;Vaccination;vaccine candidate;vaccine development;vaccine strategy;Vaccines;Viral;Virus;wild bird;Work

PROJECT_TITLE: Universal Influenza Vaccine Development


NIH_SPENDING_CATS: Genetics;Neurosciences

PI_NAMEs: JIN, HAO  (contact)

PROJECT_TERMS: Ablation;Afferent Neurons;anatomical tracing;Animals;Anti-Inflammatory Agents;Area;Brain;brain control;Brain region;Cells;Cementation;Complex;conditional knockout;cytokine;designer receptors exclusively activated by designer drugs;Dopamine-beta-monooxygenase;Dorsal;Enterobacteria phage P1 Cre recombinase;experimental study;Feedback;Functional Imaging;Ganglia;Genes;Genetic;genetic effector;Genetic Epistasis;Genetic Identity;genetic manipulation;Genetic Recombination;Goals;Gram-Negative Bacteria;imaging platform;Immediate-Early Genes;Immune;immune function;Immune response;Immune signaling;Immune Targeting;Immunity;Immunology;immunoregulation;in vivo;Inflammation;Inflammatory;inflammatory modulation;Inflammatory Response;Innate Immune Response;Label;Link;Mediating;Membrane;Monitor;Mus;Nature;neural;Neuroimmune;neuronal circuitry;Neurons;neuroregulation;Neurosciences;Nodose Ganglion;Nucleus solitarius;Peripheral;Population;Positioning Attribute;Proxy;receptor;Regulation;response;Role;Scanning;Sensory;Signal Transduction;single-cell RNA sequencing;Site;Spleen;Stimulus;Structure of area postrema;System;systemic inflammatory response;Test Result;Testing;Translating;Vagus nerve structure

PROJECT_TITLE: Elucidating the basis of brain control of innate immune responses


NIH_SPENDING_CATS: Infectious Diseases;Primary Immunodeficiencies;Rare Diseases

PI_NAMEs: ABERS, MICHAEL  (contact)

PROJECT_TERMS: acquired immunodeficiency;Adrenal Cortex Hormones;Animal Model;Autoantibodies;cell type;Chronic Granulomatous Disease;Clinical;clinically relevant;Communities;Complex;Defect;Environment;experimental study;Exposure to;Flow Cytometry;Generations;Goals;Granulocyte-Macrophage Colony-Stimulating Factor;Hereditary Disease;high dimensionality;Host Defense;Human;human model;Iatrogenesis;Immune;Immunocompromised Host;Immunologics;Immunosuppression;Impairment;improved;in vivo;Individual;Infection;Inhalation;interest;Knowledge;Modeling;mouse model;Nocardia;Nocardia Infections;novel;Outcome;pathogen;Pathogenesis;Patients;Performance;Phagocytosis;Population;Reporter;Research;Site;Stromal Cells;System;Therapeutic Intervention;Time;Tissues

PROJECT_TITLE: Immunopathogenesis of Nocardia infections


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Coronaviruses;Coronaviruses Vaccines;Emerging Infectious Diseases;Genetics;Immunization;Immunotherapy;Infectious Diseases;Prevention;Primary Immunodeficiencies;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation;Vaccine Related

PI_NAMEs: DELMONTE, OTTAVIA  (contact)

PROJECT_TERMS: 2019-nCoV;adaptive immune response;Adult;Affect;Age;aggressive therapy;Antibodies;Autoimmune Diseases;Autoimmunity;B cell differentiation;B-Lymphocytes;Caring;causal variant;Cell Compartmentation;Cephalic;Cervical;Cessation of life;Clinical;cohort;Collaborations;congenital immunodeficiency;Consensus;COVID-19 vaccination;COVID-19 vaccine;Critical Care;CTLA4 gene;CTLA4 haploinsufficiency;Cytokine Signaling;Data;Defect;Development;Diagnosis;Differentiation and Growth;disability;Disease;Disease Progression;effectiveness evaluation;Evaluation;Evolution;Facies;FLT3 ligand;FOXP3 gene;France;Generations;Genes;genetic variant;Genomics;Goals;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;Hospitalization;Hospitals;Human;Human Herpesvirus 4;humanized mouse;Immune;immune modulating agents;Immune response;Immune System Diseases;Immunity;immunodeficiency;Immunoglobulin G;immunomodulatory therapies;immunopathology;Impairment;Infection;Inflammation;insight;Interferons;Knowledge;Laboratories;Link;Longitudinal Studies;loss of function;Molecular;molecular pathology;Morbidity - disease rate;mouse model;Mutate;Mutation;NF-kappa B;NFKB Signaling Pathway;NFKB2 gene;Non-Malignant;novel;novel therapeutic intervention;Omenn syndrome;Organ;Outcome;Paris, France;Pathogenesis;Patients;Pattern;Pediatric cohort;pharmacologic;Phenotype;pre-clinical;pre-T cell receptor alpha;Predisposition;prevent;primary immune regulatory disorders;primary outcome;Production;Publishing;Quality of life;Registries;Regulatory T-Lymphocyte;Review Literature;Risk;Risk Reduction;Role;Scientist;Secondary Immunization;severe COVID-19;Severities;Signal Pathway;Signal Transduction;skin microbiome;STAT1 gene;STAT3 gain of function;STAT3 gene;Structure;Structure of thymic medulla;Symptoms;Syndrome;T-Cell Receptor;T-cell receptor repertoire;T-Lymphocyte;targeted treatment;Testing;Therapeutic;Thymus Gland;treatment and outcome;United States National Institutes of Health;Variant

PROJECT_TITLE: Primary Immune Regulatory Disorders (PIRD): Longitudinal Study of Clinical Presentation, Treatment and Outcomes


NIH_SPENDING_CATS: Clinical Research;Genetics;HIV/AIDS;Hematology;Immunotherapy;Infectious Diseases;Rare Diseases

PI_NAMEs: ROCCO, JOSEPH  (contact)

PROJECT_TERMS: Adult;adverse outcome;Autoimmune Diseases;Biological Markers;CAR T cell therapy;CD22 gene;CD8-Positive T-Lymphocytes;Cell-Mediated Cytolysis;Cessation of life;Child;chimeric antigen receptor T cells;Clinical;Clinical Management;clinical translation;cohort;Collaborations;Complex;Complication;CXCL9 gene;cytopenia;cytotoxicity;Data;Defect;Diagnosis;diagnostic criteria;Disease;effective therapy;Effector Cell;Etiology;familial hemophagocytic lymphohistiocytosis;Fever;follow-up;Functional disorder;Future;gain of function;Genes;Genetic;genetic risk factor;genetic testing;Goals;Hemophagocytic Lymphohistiocytoses;HIV;HIV Infections;Human Herpesvirus 8;IL18 gene;Immune;immune activation;immune reconstitution;Immunophenotyping;improved;Individual;Infant;Infection;Inflammasome;Inflammation;Inflammatory;Inherited;Interferon Type II;Link;longitudinal analysis;longitudinal course;longitudinal design;Longitudinal Studies;Macrophage activation syndrome;Malignant Neoplasms;meetings;Monitor;mortality;Multiple Organ Failure;mycobacterial;Mycobacterium Infections;Myelogenous;Myeloid Cells;Natural Killer Cells;neglect;novel;optimal treatments;Outcome;Pathogenesis;Pathway interactions;patient population;Patients;personalized therapeutic;Persons;Phenotype;Population;Predisposing Factor;Predisposition;Process;Production;profiles in patients;programs;prospective;Prospective cohort;Proteins;Reaction;recruit;Recurrence;Regulatory T-Lymphocyte;Research;Retrospective Studies;Rheumatism;Sampling;Syndrome;systemic juvenile idiopathic arthritis;T-Cell Activation;T-Lymphocyte;Therapeutic Clinical Trial;Therapeutic Intervention;translational research program;Treatment outcome;treatment response;Variant

PROJECT_TITLE: Pathogenesis of Secondary Hemophagocytic Lymphohistiocytosis


NIH_SPENDING_CATS: Clinical Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

PI_NAMEs: KHOURY, PANEEZ  (contact)

PROJECT_TERMS: Affect;Allergic;Allergic Disease;Area;Artificial Intelligence;biobank;Biological;Blood;Body Fluids;Caring;Clinic;Clinical;clinical care;Code;cohort;Common Data Element;Data;Data Analytics;Diagnostic;Disease;Disease Outcome;disease phenotype;epidemiology study;Goals;Immunologist;Individual;Infrastructure;Institutional Review Boards;Laboratories;Laboratory Personnel;Machine Learning;Outcome;Phenotype;Population;predictive marker;Process;Protocols documentation;repository;Resources;Sampling;Sinus;Source;Specimen;Tissues

PROJECT_TITLE: Multiple Allergic Diseases REPository (MADREP)


NIH_SPENDING_CATS: Clinical Research;Eye Disease and Disorders of Vision;Headaches;Neurodegenerative;Neurosciences;Pain Research

PI_NAMEs: KOZYCKI, CHRISTINA  (contact)

PROJECT_TERMS: Anhidrosis;Awareness;Caring;Characteristics;Clinical;clinical phenotype;cohort;Collaborations;Diagnosis;Disease;disease natural history;Edema;Enrollment;Genetic Counseling;Goals;Headache;Human Biology;Immune;Immunologics;immunomodulatory therapies;Individual;insight;Mediating;Mendelian disorder;Molecular;Mutation;Natural History;Optic Nerve;Patients;Protocols documentation;Retinal Dystrophy;Role;Sampling;sensor;Splenomegaly;Work

PROJECT_TITLE: Study of ROSAH (retinal dystrophy, optic nerve edema, splenomegaly, anhidrosis, and headache) and related diseases


NIH_SPENDING_CATS: Asthma;Biotechnology;Clinical Research;Eczema / Atopic Dermatitis;Food Allergies;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Lung;Precision Medicine;Prevention

PI_NAMEs: MATHIAS, RASIKA  (contact)

PROJECT_TERMS: Adrenal Cortex Hormones;African;African ancestry;Allergic;Allergic Disease;Allergic rhinitis;Allergy to peanuts;Americas;Asthma;Atopic Dermatitis;atopy;Binding;Biological Products;Child;clinical translation;Communication;Coupled;Data;Development;Disease;disease diagnosis;Disease susceptibility;disorder prevention;DNA Methylation;Early Intervention;efficacious treatment;epidemiology study;Epigenetic Process;Extrinsic asthma;Food Hypersensitivity;Gene Expression;Gene Expression Profile;gene network;Genes;Genetic;Genetic Code;Genetic Predisposition to Disease;Genetic Risk;genetic signature;genome resource;genome-wide;Genomics;Glucocorticoid Receptor;Goals;health disparity;health equity;Healthcare;Hypersensitivity;IgE;Immunity;Impairment;Individual;individualized medicine;Infant;Inflammation;Inhalation;insight;Learning;Libraries;Life Cycle Stages;Mediating;Methylation;Molecular;Molecular Chaperones;Multiomic Data;multiple omics;Names;Nasal Epithelium;Natural History;Nature;Onset of illness;Outcome;Peripheral Blood Mononuclear Cell;Pharmaceutical Preparations;Phenotype;Play;polygenic risk score;Population;Population Dynamics;Precision Health;Preparation;Prevention strategy;Process;Proteomics;Publications;Quality Control;Receptor Signaling;repository;Research;response;Rhinovirus;Risk;risk prediction;RNA Sequence Analysis;Role;Sampling;Severities;Severity of illness;Systems Biology;Tissues;trait;transcriptome sequencing;transcriptomics;Underrepresented Populations;Variant;wound healing

PROJECT_TITLE: Integrative-omics and Systems Biology across the atopic march


NIH_SPENDING_CATS: Aging;Biotechnology;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PROJECT_TERMS: Address;Age;Aging;aging related disease;All of Us Research Program;Alzheimer's Disease;Area;Asthma;Attention;BCL10 gene;biological age;Biological Aging;Biological Markers;Brain;brain tissue;burden of illness;Chronology;clinical implementation;clinical phenotype;clinical translation;cohort;Collaborations;Communities;Complex;dashboard;Data;Data Set;Development;Disease;disease diagnosis;disorder prevention;DNA copy number;Early Intervention;efficacious treatment;Environment;Epigenetic Process;Equity;exome;Female;follow-up;frailty;Gender;Genes;Genetic;Genetic Code;genetic variant;Genetic Variation;Genome;genome sequencing;genome wide association study;Genomics;Germ Lines;Goals;Health;health disparity;Healthcare;Heart Diseases;Hematological Disease;Hematopoiesis;high risk;Human;Human Genome;Human Genome Diversity Project;human genome sequencing;human population genetics;Individual;Inherited;Lead;Length;Literature;Lung Diseases;Measures;Metadata;Methods;Methylation;Minority Groups;Mission;Mitochondrial DNA;Mosaicism;Mucosa- associated lymphoid tissue lymphoma translocation protein-1;National Institute of Allergy and Infectious Disease;Outcome;Participant;Pathologic;Pharmaceutical Preparations;Phenotype;polygenic risk score;Population;Precision Health;Prevention strategy;programs;Protocols documentation;Publications;recruit;Research;research study;Resources;response;Risk;Risk Factors;risk prediction;Role;Science;Severity of illness;Signal Transduction;Sleep Disorders;stem;Study Subject;telomere;tool;training opportunity;Trans-Omics for Precision Medicine;Underrepresented Minority;Update;Variant;whole genome;Work

PROJECT_TITLE: Genomic underpinnings of human health and disease in the context of health disparities


NIH_SPENDING_CATS: Atherosclerosis;Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Hepatitis;Hepatitis - C;Infectious Diseases;Liver Disease

PI_NAMEs: MARCOTRIGIANO, JOSEPH  (contact)

PROJECT_TERMS: Apolipoprotein A-I;Apolipoproteins;Cells;Cholesterol Esters;density;Family;Flaviviridae;Hepatitis C virus;Hepatocyte;High Density Lipoproteins;human disease;Lipoproteins;Low Density Lipoprotein Receptor;Low-Density Lipoproteins;Mediating;member;Proteins;receptor;Role;SR-BI receptor;Very low density lipoprotein;Viral;Virion;Virus

PROJECT_TITLE: The role of apolipoproteins in viral entry and human disease


NIH_SPENDING_CATS: Brain Disorders;Infectious Diseases;Lyme Disease;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Tickborne Diseases;Vector-Borne Diseases

PI_NAMEs: HAIGH, CATHRYN  (contact)

PROJECT_TERMS: Activities of Daily Living;Acute;Address;Affect;Aftercare;Animal Model;Biological Sciences;Borrelia;Brain;Cardiac;Cell membrane;Cell Physiology;Cells;Central Nervous System;Cephalic;Cerebrum;Chromium;Chronic;Disease;Distress;Down-Regulation;Encephalitis;Encephalopathies;Environment;Equipment;erythema migrans;Europe;Exanthema;experience;Fatigue;Fever;fluorescence imaging;fluorescence microscope;Genes;Genus Hippocampus;Glucose;Headache;Human;human induced pluripotent stem cells;human model;human stem cells;imaging system;Immune;Immunofluorescence Immunologic;Impairment;in vivo;Incubated;Individual;Infection;insight;Lyme Disease;Lyme Infection;Lyme Neuroborreliosis;Meningitis;Methods;Microscopy;Mitochondria;Modeling;Morphology;Neuritis;Neurologic;Neurologic Symptoms;neuron loss;Neurons;North America;Order Spirochaetales;Organoids;Pathway interactions;Patients;Penetration;Persons;Primates;Prosencephalon;Proteins;radiculoneuritis;RANTES;Reader;Research;RNA;Scanning Electron Microscopy;Site;Skin;Spinal Cord;stem cell model;Stress;stressor;System;Techniques;tick bite;Tick-Borne Diseases;Tissues

PROJECT_TITLE: Neuroborreliosis in human neuronal and brain models.


NIH_SPENDING_CATS: Genetics

PI_NAMEs: IVANOVIC, TIJANA  (contact)

PROJECT_TERMS: Anti-viral Agents;Antibodies;Cells;Complement;Development;Environment;Evolution;genetic selection;Genetic Variation;Immune system;Infection;insight;Integration Host Factors;Methods;Mutation;next generation;novel;Pathway interactions;Phenotype;pressure;Probability;Productivity;programs;Publishing;Regulation;Research;Shapes;Technology;Viral;Virion;Virus;Virus Assembly;virus host interaction

PROJECT_TITLE: Phenotypic diversity in viral evolution


NIH_SPENDING_CATS: Infectious Diseases

PI_NAMEs: OYESOLA, OYEBOLA  (contact)

PROJECT_TERMS: Antigens;Automobile Driving;burden of illness;Cells;Color;design;Development;Environment;environmental change;Environmental Risk Factor;experimental study;Exposure to;Flow Cytometry;Genetic;helminth infection;Helminths;Heritability;Host resistance;Immune;Immune response;Immune system;Immunologics;improved;Inbred Strains Mice;Individual;individual response;Infection;Inflammatory;Injury;Intervention;Mediator;Modeling;mouse model;Outcome;Parasitic infection;Play;Predisposition;programs;prophylactic;Recording of previous events;Research;response;Role;Shapes;Stimulus;Therapeutic;Thromboplastin;Tissues;Variant;Viral Respiratory Tract Infection;Virus Diseases

PROJECT_TITLE: Investigating reprogramming of the immune system by parasitic helminths and environmental antigens


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Coronaviruses;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Emerging Infectious Diseases;Genetics;Infectious Diseases;Sexually Transmitted Infections

PI_NAMEs: SEAMAN, WILLIAM  (contact)

PROJECT_TERMS: 2019-nCoV;Acquired Immunodeficiency Syndrome;Adult;Affect;Amylases;Automobile Driving;Bacteria;Biological Assay;BK Virus;Cell Physiology;Cells;chronic inflammatory disease;cross reactivity;Development;Disease;DNA Tumor Viruses;Elements;Epigenetic Process;Epithelial Cells;Epithelium;Etiology;expression vector;Fractionation;Functional disorder;G-Protein-Coupled Receptors;gammaherpesvirus;Gene Expression;Goals;Head and Neck Cancer;HIV;HIV-1;Human;Human Herpesvirus 4;Human papilloma virus infection;Human Papillomavirus;Human papillomavirus 16;Immunoblot Analysis;Immunofluorescence Immunologic;Immunoglobulin M;Immunosuppression;in vivo;Infection;Inflammation;insight;keratinocyte;Lesion;Lymphoid;Lymphoid Cell;Lytic;Malignant Neoplasms;Mediating;microbial;MicroRNAs;mimicry;Modification;Molecular Mimicry;Monitor;Mouth Diseases;Mucous Membrane;Nuclear Export;Nucleoproteins;Oncogenic;Oncogenic Viruses;Oral;Oral cavity;oral cavity epithelium;oral HPV;oral HPV-positive head and neck cancers;oral infection;oral pathogen;Oral Pathology;Oropharyngeal;Papillomavirus;particle;pathogen;Pathogenesis;pathogenic bacteria;Pathway interactions;Patients;Periodontitis;periodontopathogen;permissiveness;Persons;pharmacologic;Phase;Phenotype;Play;prevent;Production;promoter;Protein Secretion;Proteins;Reagent;response;RNA Stability;Role;Saliva;Salivary Gland Diseases;Salivary Glands;SARS-CoV-2 transmission;Severities;Signal Pathway;Sjogren's Syndrome;Sodium Butyrate;Symptoms;targeted treatment;Telomerase;transcriptome sequencing;transmission process;tumorigenesis;United States;Viral;Viral Genes;Viral Genome;Viral Load result;Viral Pathogenesis;viral transmission;Virus;Virus Diseases;Western Blotting

PROJECT_TITLE: Viral Oral Infections in Immunosuppression and Cancer Section


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Lung;Rare Diseases;Tuberculosis

PI_NAMEs: MCCAFFREY, ERIN  (contact)

PROJECT_TERMS: 3-Dimensional;adaptive immunity;Algorithms;Antibodies;antimicrobial;Bacteria;Barbering;Benchmarking;biobank;Biological Assay;Biological Models;Blood Banks;Cells;Clinical;cohort;Collaborations;Collagen;Communicable Diseases;Containment;COVID-19;Cytokine Signaling;Data;data analysis pipeline;Data Set;Disease;Doctor of Philosophy;effective therapy;Environment;Goals;Granuloma;high dimensionality;HIV;Human;human imaging;human model;Humanities;Hypoxia;Image;imaging approach;imaging platform;imaging program;Imaging Techniques;Immune;Immune Evasion;Immune response;Immunity;Immunologics;Immunology;In Situ;In Vitro;Individual;Infection;Inflammation;Investigation;Label;Laboratories;Link;Lung;Lymph Node Tuberculosis;lymph nodes;Macaca fascicularis;Macaca mulatta;Macrophage;Maps;Metabolic Pathway;Metabolism;microbial;Modeling;mouse model;multi-scale imaging data;Multiplexed Ion Beam Imaging;Mus;Mycobacterium tuberculosis;National Institute of Allergy and Infectious Disease;nonhuman primate;Organoids;Outcome;Parasitic Diseases;pathogen;Pathogenesis;Pathology;Pathway interactions;peripheral blood;Peripheral Blood Mononuclear Cell;permissiveness;Pimonidazole;Postdoctoral Fellow;prevent;Proteins;Proteome;Protocols documentation;Publishing;Regimen;Reporter;Reporting;Research;response;Sarcoidosis;single-cell RNA sequencing;Site;small molecule;Specimen;Structure;System;Technology;Therapeutic;Time;tissue mapping;Tissues;Training;transcriptome;transcriptomics;Treatment Protocols;Tuberculosis;tuberculosis granuloma;tuberculosis treatment;tumor;United States National Institutes of Health;Universities;Vaccines;Visualization;Work

PROJECT_TITLE: Spatially mapping and modeling tuberculosis granulomas to define the immunological determinants of infection outcome


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Infectious Diseases;Lung;Prevention;Social Determinants of Health

PI_NAMEs: GERMOLEC, DORI R (contact)

PROJECT_TERMS: 2019-nCoV;adaptive immune response;Address;Adoption;adverse outcome;Affect;Age;Animals;Anosmia;Antibodies;authority;Awareness;Biological;Biological Assay;Biological Models;Biology;Blood;California;Cell Culture Techniques;Cell Physiology;Cell-Mediated Cytolysis;Cells;chemokine;Clinical;Clinical Data;clinical database;Communicable Diseases;Complex;COVID-19;COVID-19 pathogenesis;COVID-19 patient;COVID-19 susceptibility;COVID-19 therapeutics;COVID-19 treatment;cytokine;cytotoxicity;Data;Database Management Systems;Databases;demographics;design;Development;Discipline;Disease;Disease Progression;Educational workshop;Ensure;Environment;Environmental Exposure;Environmental Impact;Environmental Risk Factor;epidemic potential;Ethnic Origin;Evaluation;Event;exposed human population;Funding;Future;Gender;Government;Human;human tissue;Immune;immune function;Immune response;In Vitro;in vitro Assay;in vitro testing;in vivo;Individual;induced pluripotent stem cell;Inflammatory;Influenza;Informatics;Innate Immune Response;International;Knowledge;Laboratories;Link;Literature;Maps;member;microphysiology system;Modeling;Multiple Organ Failure;National Institute of Allergy and Infectious Disease;Natural Killer Cells;network models;novel therapeutics;Outcome;Paper;Pathogenesis;Pathway interactions;Performance;Phase;Population;pre-clinical;Predisposition;Production;programs;prospective;Protocols documentation;Public Health;Publications;Publishing;Readiness;Recording of previous events;repository;Reproductive Health;Research;Research Personnel;respiratory;Respiratory distress;response;Risk;safety assessment;San Francisco;Scientist;Series;Site;Source;Standardization;statistics;Stream;System;systematic review;T-Lymphocyte;Technology;technology platform;Tissue Microarray;Toxicology;Translating;Universities;uptake;validation studies;Viral;Viral Antigens;Viral Respiratory Tract Infection;virtual;Virus;Virus Diseases;webinar;Whole Blood;Work;working group

PROJECT_TITLE: Research Initiatives on COVID-19 in the Division of Translational Toxicology


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Breastfeeding, Lactation and Breast Milk;Cardiovascular;Genetics;HIV/AIDS;Heart Disease;Infectious Diseases;Maternal Health;Neurosciences;Nutrition;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Women's Health Research

ORG_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

PI_NAMEs: SANTOS, JANINE  (contact)

PROJECT_TERMS: 1 year old;abacavir;Acceleration;Acquired Immunodeficiency Syndrome;Address;Adult;Adult Children;Adverse drug effect;Adverse effects;Age Months;age related;aged;Aging;Anatomy;Animal Experimentation;animal old age;Animals;antiretroviral therapy;Area;Astrocytes;Axon;behavior test;Behavioral;Biochemical;biological adaptation to stress;Body System;Body Weight;Bone Growth;Brain region;Carbon;Cardiac Myocytes;Cardiovascular system;Cell Culture Techniques;Cells;Child;Chronic;Clinical;cognitive function;cohort;Combination Drug Therapy;Combined Modality Therapy;Complex;Data;Development;Developmental Gene;Disease;Drug Exposure;Echocardiography;Electrocardiogram;Electrophysiology (science);Environment;Evaluation;evidence base;Experimental Animal Model;experimental study;Exposure to;fatty acid metabolism;Fatty Acids;Female;fetal;Fetus;food consumption;Fright;Funding;Future;Gene Expression;Gene Expression Profile;Generations;Genetic Transcription;Genomics;Glucose;Glutamates;Guidelines;Health;Heart;heart function;Histopathology;HIV;HIV Infections;HIV/AIDS;Human;human induced pluripotent stem cells;Immune response;improved;In Vitro;indexing;Infection;Inflammaging;interest;Kinetics;Laboratory Animals;Lactation;Lamivudine;late life;Left atrial structure;Left ventricular structure;Life;life span;lipid metabolism;Lipids;Lipopolysaccharides;Long-Term Effects;Macrophage;Maintenance;male;Mass Spectrum Analysis;Maternal Health;maternal risk;Measures;Medicine;Metabolism;Microglia;Mitochondria;Modeling;Morphology;Motor;Myocardial dysfunction;Nervous System;neural network;Neuroimmune;Neurologic;Neurotransmitters;Nucleotides;offspring;older patient;Outcome;Patients;Pattern;pediatric patients;Perinatal Exposure;Pharmaceutical Preparations;pharmacologic;postnatal;Postpartum Period;Pregnancy;pregnant;Pregnant Women;prenatal exposure;Process;Productivity;programs;pup;Rattus;Regimen;Reproduction;reproductive;Research;response;Reverse Transcriptase Inhibitors;Risk;risk minimization;Rodent;Rodent Model;Role;Severity of illness;Sex Differences;side effect;synaptogenesis;System;Therapeutic;Therapeutic Effect;Therapeutic Intervention;Tissues;Toxic effect;Toxicology;transcriptome sequencing;Viral Load result;Viral Proteins;Virus;Virus Replication;Vulnerable Populations;Weaning;Weight Gain;Work;Yolk Sac;young adult

PROJECT_TITLE: Research Initiatives on AIDS and HIV in the Division of Translational Toxicology


NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Complementary and Integrative Health;Dietary Supplements;Natural Products;Nutrition;Prevention

PI_NAMEs: RIDER, CYNTHIA  (contact)

PROJECT_TERMS: Address;adverse outcome;Animals;Area;Aromatic Polycyclic Hydrocarbons;Biological Assay;Botanicals;carcinogenicity;Carcinogens;Cells;Chemical Actions;Chemicals;Collaborations;Communities;Community of Practice;Complex;Complex Mixtures;Data;Data Analyses;Decision Making;dietary supplements;Dose;Drug Kinetics;Environmental Exposure;Evaluation;Exposure to;Foundations;Fractionation;Future;Garcinia cambogia;Goals;hazard;Human;in silico;In Vitro;Individual;Joints;Learning;Methods;Modeling;National Center for Advancing Translational Sciences;Pathway interactions;Poly-fluoroalkyl substances;predictive modeling;programs;Public Health;public-private partnership;Reporting;Research;response;Risk;Risk Assessment;Safety;Sampling;Serum;Smoke;stressor;Structure;superfund site;Systems Biology;Testing;tool;Toxic effect;Toxicology;Translating;Uncertainty;Valerian;Wildfire;wood smoke;Work

PROJECT_TITLE: Combined Exposures and Mixtures Research Program


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Health Effects of Indoor Air Pollution;Lung;Nanotechnology

PI_NAMEs: RYAN, KRISTEN  (contact)

PROJECT_TERMS: Acute;Address;Aerosols;Affect;Agreement;Air;Amphiboles;Asbestosis;Asthma;Body System;Cancer Etiology;Cessation of life;Chronic;Data;Decision Making;Dermal;design;Development;Disease;Dose;double walled carbon nanotube;Ensure;Environment;Evaluation;exposed human population;exposure route;Exposure to;Fibrosis;Future;Gasoline;General Population;Goals;graphene;Guidelines;hazard;Health;health assessment;Health Hazards;Histopathology;Human;Hypersensitivity;In Vitro;in vitro Model;in vivo;in vivo monitoring;Industry;Inhalation;Inhalation Exposure;Inhalation Toxicology;innovation;International;interstitial;Link;Liquid substance;Lung;Lung Diseases;Malignant neoplasm of lung;Manuscripts;method development;microphysiology system;Mineral Fibers;Modeling;Monoterpenes;Mus;Nail plate;National Institute for Occupational Safety and Health;National Institute of Environmental Health Sciences;novel;Occupational;Occupational Diseases;Occupational Exposure;Organ;Physiologic Monitoring;Pleural Diseases;Poison;Poly-fluoroalkyl substances;Process;programs;Protocols documentation;Publications;Published Comment;Radiation;Rattus;Reporting;Research;Respiratory Disease;Respiratory System;response;Risk;Route;Science;Silicosis;Stachybotrys;symposium;System;Techniques;technology development;Tissues;tool;Toxic effect;Toxicology;Trust;Validation;volatile organic compound;Work;Workplace

PROJECT_TITLE: Occupational and Inhalation Exposures Research Program


NIH_SPENDING_CATS: Bioengineering;Endocrine Disruptors;Foodborne Illness;Pediatric;Prevention;Social Determinants of Health

PI_NAMEs: BLYSTONE, CHAD  (contact)

PROJECT_TERMS: Acute;Address;Adult;Affect;Agreement;Boron;carcinogenicity;Case Study;chemical release;Chemicals;Child;Chronic;Clothing;Collaborations;Color;Communities;Community of Practice;Data;Development;developmental toxicity;Disasters;Disease;drinking water;Dyes;Educational workshop;Emergency Situation;Engineering;Environment;Evaluation;expectation;exposed human population;Exposure to;food consumption;Genetic;genomic signature;genotoxicity;Goals;Half-Life;hazard;Health;health assessment;Health Hazards;Heavy Metals;Human;Immune;immunotoxicity;improved;Infant;Integrative Medicine;interest;Knowledge;Lead;Legal;Link;Malignant Neoplasms;Manuscripts;marginalized community;Medicine;meetings;member;Metabolism;Methods;Mission;mortality;Mothers;Mus;nano;Ohio;Oncorhynchus kisutch;Oral;Outcome;Peer Review;Perinatal;Perinatal Exposure;persistent organic pollutants;Phenylenediamines;Pilot Projects;Plasma;Politics;Population;Predisposition;Program Research Project Grants;Program Reviews;programs;Public Health;public health research;Publications;Published Comment;Rain;Rattus;Reporting;reproductive toxicity;Research;Resources;response;Rewards;Risk;Risk Assessment;Scanning;Science;Series;Source;success;Summary Reports;systematic review;Thallium;Time;tool;Toxic effect;Toxicology;Training;Umbilical Cord Blood;United States National Academy of Sciences;United States National Institutes of Health;Validation;Water consumption;Water Pollutants;Work;working group

PROJECT_TITLE: Emerging Contaminants and Issues of Concern Research Program


NIH_SPENDING_CATS: Clinical Research;Health Effects of Indoor Air Pollution;Pediatric

PI_NAMEs: TAYLOR, KYLA  (contact)

PROJECT_TERMS: Address;Adopted;Adult;Case Study;Categories;chemical group;Chemicals;cheminformatics;Classification;Combined Modality Therapy;Communication;consumer product;Country;Data;Decision Making;Development;Disease;Educational workshop;effectiveness evaluation;Evaluation;evidence base;Exposure to;Fetal Growth;Fetal Growth Retardation;Fire - disasters;Flame Retardants;Goals;Grouping;halogenation;hazard;Hazard Assessment;Health;Health Hazards;HIV;Human;Information Dissemination;interest;Investigation;late life;Life;Literature;Malignant Neoplasms;Maps;meetings;Methodology;Methods;National Institute for Occupational Safety and Health;Nongovernmental Organizations;novel;novel strategies;Participant;Patients;personal care products;Persons;Pregnancy;programs;Property;pubertal timing;Puberty;Public Health;Publications;Research;Risk;Risk Assessment;side effect;Targeted Research;Therapeutic;Therapeutic Effect;Therapeutic Research;tool;Toxic effect;Toxicity Tests;Toxicology;United States Environmental Protection Agency;United States National Institutes of Health

PROJECT_TITLE: Consumer Products and Therapeutics Research Program


NIH_SPENDING_CATS: Endocrine Disruptors

PI_NAMEs: FERGUSON, STEPHEN  (contact)

PROJECT_TERMS: Address;aqueous;aspirate;bioaccumulation;Chemicals;Chemistry;Collaborations;Communication;community engagement;Companions;Complex;Complex Mixtures;Data;data streams;Department of Defense;design;Development;Educational workshop;Environmental Exposure;Environmental Health;Film;Fostering;Generations;Goals;Half-Life;Health;Hepatocyte;Human;In Vitro;in vivo;Individual;innovation;Interagency Coordinating Committee on the Validation of Alternative Methods;Kidney;Liver;Manuscripts;Maps;meetings;microphysiology system;Modeling;next generation;Oral;Poly-fluoroalkyl substances;Positioning Attribute;programs;prospective;public-private partnership;Publications;Qualifying;Research;Research Design;Risk Assessment;Safety;Sampling;Science;screening;Series;Structure;System;Technology;Testing;Time;Tissue Microarray;Tissue Model;tool;tool development;Toxic effect;Toxicology;Work;working group

PROJECT_TITLE: Safe and Sustainable Alternatives Research Program


ACTIVITY: ZIC

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Data Science;Genetics;HIV/AIDS;Human Genome;Infectious Diseases;Networking and Information Technology R&D (NITRD)

PI_NAMEs: CHERRY, JAMES  (contact)

PROJECT_TERMS: 3-Dimensional;Address;animation;Antibodies;Area;artificial intelligence model;Ascites;assay development;ATAC-seq;Biochemical;Bioinformatics;Biological;Biological Assay;Biometry;biophysical analysis;Biophysics;Biotechnology;biotypes;Cell Separation;Cells;Chemicals;Chemistry;ChIP-seq;Collaborations;Collection;Color;Communicable Diseases;Communication;Communities;Complex;complex data;Computational Biology;Computational Science;Computer software;Computers;Confocal Microscopy;Consultations;cost;Coupling;Cryoelectron Microscopy;Custom;Cytometry;Data;Data Analyses;Data Collection;Data Display;data integration;Data Science;data science resource;Dedications;design;detection method;Development;Discipline;DNA;DNA sequencing;Educational process of instructing;Educational workshop;Electron Microscopy;Electrons;Environment;Equipment;experience;experimental analysis;Experimental Designs;experimental study;Explosion;Extramural Activities;Flow Cytometry;Fluorescence;Fluorochrome;Genetic;genome-wide;Genomics;Goals;High-Throughput Nucleotide Sequencing;Hybridomas;Image;Image Analysis;Image Cytometry;image processing;image visualization;Imaging technology;Immune Sera;Immunology;Industry;Infrastructure;innovation;instrument;instrumentation;interest;Interferometry;Internet;Intramural Research;Intramural Research Program;intravital imaging;Investigation;Kinetics;Label;Lasers;Licensing;Light;Light Cell;light microscopy;Link;lipidomics;Machine Learning;macromolecule;Manuscripts;Maryland;Mass Spectrum Analysis;metabolomics;method development;Methods;Microscope;Microscopy;Mission;models and simulation;molecular modeling;Montana;multi-photon;multiple omics;National Heart, Lung, and Blood Institute;National Institute of Allergy and Infectious Disease;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;National Institute of Diabetes and Digestive and Kidney Diseases;new technology;next generation sequencing;operation;Optics;outreach;Pamphlets;posters;Preparation;Printing;programs;Protein Chemistry;protein folding;Proteins;proteogenomics;Proteomics;Protocols documentation;Publications;reconstruction;Regimen;Research;Research Activity;Research Personnel;Reservations;Resources;Rest;RNA;Roentgen Rays;Running;Sampling;Science;Scientist;Services;Site;Sorting;Speed;Statistical Data Interpretation;structural biology;Structure;System;Techniques;Technology;technology development;Testing;three-dimensional modeling;Time;Training;Training and Education;transcriptome sequencing;Transportation;United States National Institutes of Health;web interface;web site;Work

PROJECT_TITLE: Infectious Diseases Collaborative Technological Research Resources - Bethesda


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics;Human Genome;Infectious Diseases;Networking and Information Technology R&D (NITRD)

PROJECT_TERMS: 3-Dimensional;Address;animation;Antibodies;Antigens;Area;Arts;Ascites;ATAC-seq;Bacteria;Bioinformatics;Biological;Biological Assay;Biotechnology;Cell Separation;Cells;Chemicals;ChIP-seq;Collaborations;Color;Communicable Diseases;Communication;Communities;Complex;Computational Biology;Computers;Confocal Microscopy;Consultations;Contracts;cost;Coupling;Cryoelectron Microscopy;cryogenics;Custom;Data;Data Analyses;Data Collection;data management;Dedications;design;Development;digital;digital technology;Discipline;DNA;DNA sequencing;Educational process of instructing;Electron Microscopy;Electrons;Environment;Equipment;experience;experimental analysis;Experimental Designs;experimental study;Explosion;Extramural Activities;Flow Cytometry;Fluorochrome;Freezing;Genetic;genome-wide;Genomics;Goals;High-Throughput Nucleotide Sequencing;Human;Human Resources;Hybridomas;Image;imaging informatics;Imaging technology;Immune;Immune Sera;Immunology;improved;Industry;innovation;instrumentation;interest;Internet;Internships;Intramural Research;Intramural Research Program;Investigation;Ions;Label;Laboratories;Lasers;Light;light microscopy;Lighting;Link;Machine Learning;Macromolecular Complexes;Maryland;Medical;meetings;method development;Methods;Microscope;Microscopy;Mission;Montana;National Institute of Allergy and Infectious Disease;new technology;next generation sequencing;operation;Optics;outreach;Pamphlets;Parasites;pathogen;Photography;Preparation;preservation;Proteins;proteogenomics;Proteomics;Protocols documentation;Research;Research Personnel;Reservations;Resolution;Resources;Rest;RNA;Running;Sampling;Scanning Electron Microscopy;Scientist;Services;Site;Sorting;Specimen;Speed;Statistical Data Interpretation;Structure;superresolution microscopy;System;Techniques;Technology;technology development;technology/technique;Testing;Three-dimensional analysis;three-dimensional visualization;Time;Training;Training and Education;transcriptome sequencing;Transportation;United States National Institutes of Health;Virus;Visual;Visualization;web interface;web site;Work

PROJECT_TITLE: Infectious Diseases Collaborative Technological Research Resources- RML


NIH_SPENDING_CATS: Clinical Research;Emerging Infectious Diseases;Immunotherapy;Infectious Diseases;Networking and Information Technology R&D (NITRD)

PROJECT_TERMS: 2019-nCoV;Biological;Biological Assay;Categories;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;clinical application;Clinical Research;Collaborations;Computer Analysis;computer framework;Computer Models;Data;data management;data mining;data modeling;Data Set;Development;Ensure;Experimental Designs;experimental study;falls;Flow Cytometry;Goals;high dimensionality;Human;Immune;Immunologic Monitoring;Immunologics;Immunology;Immunotherapy;Infection;insight;Intervention;Leadership;Mission;Molecular;Monitor;Outcome;Phase;Procedures;Proteomics;Reporting;Research;Research Design;Research Personnel;Resources;sample collection;System;Technology;technology development;transcriptomics;Translational Research;United States National Institutes of Health;Vaccination;web site;Work

PROJECT_TITLE: Center for Human Immunology


PI_NAMEs: LIONAKIS, MICHAIL  (contact)

PROJECT_TERMS: Affect;animal facility;Antibiotics;Autoimmune Diseases;Cardiovascular Physiology;Cells;Chronic;Circadian Rhythms;Clinical;clinical center;Collaborations;Country;design;Diet;Disease;Equipment;facility renovation;Genes;Gnotobiotic;gut microbiota;Health;Hematopoietic;Homeostasis;Human;Hypersensitivity;Immunologics;Income;Infection;Inflammation;Inflammatory;Insect Vectors;Institution;International;Lung;lung microbiota;Macaca;Maintenance;Metabolic;Metabolism;metabolome;metagenome;microbial;Microbiology;microbiome;microbiome research;microbiome sequencing;microbiota;Mission;multi-drug resistant pathogen;Mus;National Institute of Allergy and Infectious Disease;neoplastic;Nervous System Physiology;Neurologic;novel;Parasitic infection;pathogen;pathogenic microbe;Pathology;Physiology;Play;Prevention;programs;Research;Research Personnel;Research Support;resilience;Role;Sampling;Scientist;sequencing platform;Severities;Site;Skin;skin microbiota;Structure;Tissues;Vaccines;Work

PROJECT_TITLE: NIAID Microbiome Program


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Immunization;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza;Vaccine Related

PI_NAMEs: ARORA, GUNJAN  (contact)

PROJECT_TERMS: 2019-nCoV;Animal Model;Animals;Anosmia;Anti-viral Agents;Benign;betacoronavirus;Biology;Birds;Camels;Case Fatality Rates;Cellular biology;Cessation of life;Child;China;Chiroptera;Circulation;Cities;Clinical;Clinical Research;Common Cold;Containment;Core Facility;Coronavirus;Coughing;Country;COVID-19;COVID-19 pandemic;COVID-19 patient;Development;Diarrhea;Disease;Disease Outbreaks;Elderly;Environment;Evolution;experimental study;Family;Fatigue;Fever;Genome;Goals;Headache;Hospitalization;Human;Immunocompromised Host;Individual;Infection;Intramural Research;Intramural Research Program;Intubation;Link;Mammals;Middle East Respiratory Syndrome Coronavirus;Molecular Biology;Monoclonal Antibodies;Morbidity - disease rate;mortality;Myalgia;Names;National Institute of Allergy and Infectious Disease;Nausea;new pandemic;novel coronavirus;Patients;Persons;Pneumonia;Population;Province;Public Health;Research;Research Personnel;respiratory;Respiratory Disease;response;RNA;Sampling;SARS coronavirus;SARS-CoV-2 immunity;SARS-CoV-2 pathogenesis;seasonal coronavirus;Severe Acute Respiratory Syndrome;Shortness of Breath;Sore Throat;Source;Stress;Symptoms;Taste Perception;Training;translational study;transmission process;United States National Institutes of Health;Vaccination;Vaccines;Variant;virology;Virus;Viverridae;Vomiting;Zoonoses

PROJECT_TITLE: SARS-CoV-2 Virology Core


NIH_SPENDING_CATS: Cancer;Complementary and Integrative Health;Endocrine Disruptors;Prevention

PI_NAMEs: WALKER, NIGEL J (contact)

PROJECT_TERMS: Adverse effects;Area;Aromatic Hydrocarbons;Aromatic Polycyclic Hydrocarbons;biological systems;Botanical dietary supplements;carcinogenicity;Carcinogens;Cardiovascular system;Chemicals;Cimicifuga racemosa;Collaborations;Communication;Congresses;Data;data management;Database Management Systems;Development;disorder prevention;Economics;Evaluation;exposed human population;Exposure to;Flame Retardants;Fluorides;genotoxicity;Goals;halogenation;hazard;Hazard Assessment;Hazardous Substances;Health;Health Policy;Human;Immune system;in vitro Model;in vivo;interactive tool;Journals;Knowledge;Literature;Malignant Neoplasms;Mission;Monograph;nanomaterials;National Institute for Occupational Safety and Health;National Institute of Environmental Health Sciences;National Toxicology Program;Nervous System;operation;Peer Review;Persons;phthalates;Poly-fluoroalkyl substances;Preparation;programs;Public Health;Publications;Quinones;Reporting;Reproduction;Research;Research Activity;Research Design;Research Infrastructure;Research Support;Safety;Science;Sunscreening Agents;systematic review;Toxic effect;Toxicology;Triclosan;United States;United States Dept. of Health and Human Services;United States Food and Drug Administration;web site;wood smoke;Work

PROJECT_TITLE: Research Infrastructure and Operations  Supporting  the National Toxicology Program (NTP)


ACTIVITY: ZIE

NIH_SPENDING_CATS: HIV/AIDS

PI_NAMEs: SHAFFER, MEREDITH  (contact)

PROJECT_TERMS: Appointment;Board Certification;Canada;Clinical;clinical center;Clinical Investigator;Clinical Research;Credentialing;Doctor of Medicine;Doctor of Philosophy;Eligibility Determination;experience;falls;Industry;Laboratories;Left;Mississippi;National Heart, Lung, and Blood Institute;National Institute of Allergy and Infectious Disease;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;Participant;Physicians;Positioning Attribute;programs;Qualifying;Research Personnel;System;tenure track;Training;Translational Research;United States National Institutes of Health;Universities

PROJECT_TITLE: NIAID Transition Program in Clinical Research


NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Patient Safety;Pediatric

PI_NAMEs: KHOURY, PANEEZ  (contact)

PROJECT_TERMS: academic review;Accreditation;Allergic;Allergic Disease;Area;Artificial Intelligence;Autoimmune Diseases;base;Basic Science;candidate selection;career;career development;certificate program;Climate;Clinic;Clinical;clinical center;clinical development;Clinical Immunology;clinical investigation;Clinical Protocols;Clinical Research;clinical training;Clinical Trials;congenital immunodeficiency;Continuity of Patient Care;design;Development;didactic education;disparity reduction;diversity and equity;Education;Ensure;experience;Extramural Activities;Faculty;Faculty Workshop;Fellowship;Fellowship Program;flipped classroom;Foundations;Genetic;Genomics;Goals;Government;graduate medical education;Grant;Health;health disparity;human subject protection;Hypersensitivity;Immersion;Immune Complex Diseases;Immune System Diseases;immunodeficiency;Immunology;improved;In Situ;Inosine Diphosphate;Internist;Interview;Intramural Research Program;Investigation;lectures;medical specialties;Mentors;Mentorship;Mind;Mission;National Institute of Allergy and Infectious Disease;Patient Care;Patients;pediatrician;Pharmacologic Substance;Physicians;Policies;Pollution;Preparation;Productivity;programs;Protocols documentation;Qualifying;recruit;Research;Research Personnel;Research Project Grants;Research Subjects;Research Training;Residencies;Resources;Review Committee;Rotation;Science;Series;simulation;Site;Teacher Professional Development;Time;Training;Training Programs;Translational Research;Transplantation;United States National Institutes of Health;Universities;virtual reality;Work;Writing

PROJECT_TITLE: Allergy and Immunology Clinical Fellowship Program Support


NIH_SPENDING_CATS: HIV/AIDS;Infectious Diseases;Pediatric

PI_NAMEs: ZERBE, CHRISTA  (contact)

PROJECT_TERMS: Academic Medical Centers;academic review;Accreditation;American;antimicrobial;Antimicrobial Resistance;base;Basic Science;career;career preparation;Certification;Child;Childhood;Clinical;clinical center;Clinical Research;Clinical Skills;clinical training;Clinical Trials;Collaborations;Communicable Diseases;Complex;Consult;design;driving force;Eligibility Determination;Environment;experience;Extramural Activities;faculty research;falls;Fellowship;Fellowship Program;Functional disorder;Funding;Goals;graduate medical education;Hearing;Hospitals;Host Defense;Immunology;Individual;Internal Medicine;Internist;Interview;Intramural Research Program;Laboratories;Leadership;Medical center;medical specialties;Medicine;Mentors;Microbiology;Mission;National Institute of Allergy and Infectious Disease;Pathogenesis;Pathology;Patients;Physicians;Private Practice;Process;Productivity;programs;Qualifying;recruit;Research;Research Personnel;Research Project Grants;Research Training;Resources;Review Committee;Rotation;Supervision;Training;Training Programs;Translational Research;Transplantation;United States National Institutes of Health;University Hospitals;vaccine development;virology;Washington;Work

PROJECT_TITLE: Infectious Diseases Fellowship Program


ACTIVITY: ZIG

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Coronaviruses;Emerging Infectious Diseases;Genetics;HIV/AIDS;Immunization;Infectious Diseases;Neurosciences;Prevention;Vaccine Related;Vaccine Related - AIDS

PI_NAMEs: ELKINS, WILLIAM  (contact)

PROJECT_TERMS: 2019-nCoV;ACE2;Aerobic;Affect;air filter;Amino Acids;Animal Experimentation;Animal Model;animal model development;Animals;assisted reproduction;Autopsy;Backcrossings;Beds;Binding;Biopsy Specimen;Bioterrorism;Board Certification;Books;Breeding;Caring;Cell Transplantation;Cells;cerebral vascularization;Cerebrum;Cessation of life;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Coculture Techniques;Collaborations;Communicable Diseases;comparative;Complex;Confounding Factors (Epidemiology);congenic;Congenic Mice;Contracts;cost;COVID-19;CRISPR/Cas technology;Cryopreservation;Data;Derivation procedure;design;Diagnosis;Diagnostic;Diagnostic tests;Disease;Disease Progression;Distress;DNA Sequence Analysis;Electroporation;Embryo;embryo cryopreservation;Emerging Communicable Diseases;Endothelial Cells;Environment;Equipment;Evaluation;Exclusion;experience;Experimental Designs;experimental study;Female;Fertilization in Vitro;Food;Formalin;Gene Modified;Gene Targeting;Generations;Genes;Genetic;genome editing;Germ-Free;Gnotobiotic;Health;Hematopoietic stem cells;Hematoxylin and Eosin Staining Method;high efficiency particulate air filter;Human;human induced pluripotent stem cells;Human Resources;Hypersensitivity;IACUC;Immunofluorescence Immunologic;Immunohistochemistry;improved;In Situ Hybridization;Individual;induced pluripotent stem cell;Infection;Insertion Mutation;Internal Ribosome Entry Site;Journals;Knock-in;Knockout Mice;Knowledge;Label;Laboratories;Laboratory Animal Medicine;Laboratory Animals;Manuscripts;Medical;medical countermeasure;medical specialties;Medicine;Methods;Microglia;microorganism;Microscopic;Microscopy;Mission;Modeling;Modification;Molecular;mouse genetics;mouse model;Mus;National Institute of Allergy and Infectious Disease;Neuroglia;Neurons;Newborn Infant;novel;novel marker;Organism;Organoids;Pain;Paraffin Embedding;Pathogenesis;Pathologist;Pathology;Pathology Report;Patients;Peer Review;Peptides;Play;Pluripotent Stem Cells;posters;Preparation;Prevention;Principal Investigator;Process;programs;Proteins;Protocols documentation;PTPRC gene;Public Health;Publications;Publishing;pup;receptor;repository;Research;Research Activity;Research Personnel;Research Support;Resources;Role;routine imaging;SARS-CoV-2 infection;Services;Side;Slide;Source;Specialist;sperm cell;sperm cryopreservation;Stains;stem cells;success;System;Technical Expertise;Techniques;therapy development;Time;Tissue Banks;Tissue Embedding;Tissues;Titrations;Training;United States National Institutes of Health;Veterinary Pathology;Virus;Vision;Work

PROJECT_TITLE: Comparative Medicine Infectious Diseases- Bethesda


NIH_SPENDING_CATS: Infectious Diseases

PI_NAMEs: HANLEY, PATRICK  (contact)

PROJECT_TERMS: Affect;Animal Experimentation;Animal Model;Animals;Bioterrorism;Caring;Clinical;Communicable Diseases;Data;Development;Disease;Environment;experience;Goals;Human;infectious disease treatment;Infectious Diseases Research;Investigation;Knowledge;Laboratory Animal Medicine;Laboratory Animal Models;Laboratory Animals;Medical;Mission;Mus;National Institute of Allergy and Infectious Disease;Organism;Pathology;Research;Research Activity;Research Personnel;Research Support;Resources;Services;Side;Technical Expertise;Work

PROJECT_TITLE: Veterinary Services Core for Infectious Diseases Research- RML


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Coronaviruses;Emerging Infectious Diseases;Infectious Diseases

PROJECT_TERMS: Affect;Animal Experimentation;Animal Model;Animals;Bioterrorism;Caring;Clinical;Communicable Diseases;COVID-19;Data;Development;Disease;Environment;experience;Goals;Histopathology;Human;infectious disease treatment;Infectious Diseases Research;Investigation;Knowledge;Laboratory Animal Medicine;Laboratory Animal Models;Laboratory Animals;Medical;Mission;Mus;National Institute of Allergy and Infectious Disease;Organism;Pathology;Research;Research Activity;Research Personnel;Research Support;Resources;Side;Technical Expertise;Work

PROJECT_TITLE: Animal Research Support of COVID Studies


ACTIVITY: ZIJ

PI_NAMEs: SOUCY, KATHRYN  (contact)

PROJECT_TERMS: Advisory Committees;Agreement;Area;Award;Awareness;Back;Bibliometrics;Biomedical Research;Caliber;career;career development;Chalk;Clinical;Clinical Investigator;cohort;Collaborations;college;Communication;Data;Databases;design;Development;Development Plans;diversity and inclusion;Education;Educational Status;Educational workshop;Electronic Mail;Elements;Ensure;Equilibrium;Evaluation;Event;experience;Exposure to;Faculty;Feedback;Fellowship;Fellowship Program;flexibility;Fostering;Funding;Goals;graduate school;graduate student;Grant;high school;improved;Individual;insight;Institution;interest;Internships;Interview;Job Application;Laboratories;Learning;lectures;Lightning;Maryland;matriculation;medical schools;Medical Students;member;Mentors;Mission;Montana;National Institute of Allergy and Infectious Disease;Occupations;outreach;Participant;Personal Communication;Persons;Population;Population Heterogeneity;Positioning Attribute;Postbaccalaureate;Postdoctoral Fellow;posters;pre-doctoral;Problem Solving;Process;Professional Organizations;Program Evaluation;programs;prospective;recruit;Reporting;Research;research and development;Research Training;Resources;Role;Running;Schedule;Science;Series;Site;skill acquisition;skills;social media;Societies;Specialist;Students;summer internship;summer student;System;Time;Time Management;Training;training opportunity;Training Programs;trend;Underrepresented Populations;United States National Institutes of Health;Universities;virtual;Visit;Vocational Guidance;web page;web site;Writing

PROJECT_TITLE: Office of Research Training and Development


ADMINISTERING_IC: AT

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Complementary and Integrative Health;Dietary Supplements;Emerging Infectious Diseases;Infectious Diseases;Microbiome;Nutrition

ORG_CITY: PROVIDENCE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_FIPS: US

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: NARRATIVE Antibiotic-induced microbiome disruption is associated with acute and long-term morbidity. Here we propose that a mechanistic understanding of the impact of the redox environment on gut antibiotic toxicity may be used to identify anti-disruptive therapies. Developing anti-destructive therapies will help the millions of Americans that receive antibiotics each year by reducing the risk of detrimental outcomes and improving the use of our current antimicrobial arsenal while we fight the antibiotic resistance crisis.

PI_NAMEs: BELENKY, PETER  (contact)

PROGRAM_OFFICER_NAME: KIM, HYE-SOOK

PROJECT_TERMS: Acute;Aerobic;American;Anti-microbial susceptibility;Antibiotic Resistance;Antibiotic susceptibility;Antibiotic Therapy;Antibiotics;antimicrobial;Automobile Driving;Bacterial Antibiotic Resistance;Basic Science;Clostridium difficile;Colitis;combat;Communities;Complex;Data;Diabetes Mellitus;Dietary Fiber;dietary supplements;dysbiosis;Effectiveness;Environment;evidence base;Fermentation;Fiber;fighting;Functional disorder;gut microbiome;Health;improved;Intervention;Link;Measurement;Mediating;Metabolic;metabolic rate;Metabolism;microbial;microbiome;microbiome components;Morbidity - disease rate;novel;novel therapeutics;Obesity;Organ;Outcome;Oxidation-Reduction;pathobiont;Pathway interactions;Plants;Polysaccharides;prebiotics;Predisposition;preservation;Probiotics;Production;Recovery;Research;resilience;respiratory;Risk Reduction;Role;small molecule;Solid;Supplementation;Testing;Therapeutic;Time;Tissues;Toxic effect;Translating;translational impact;Vulnerable Populations

PROJECT_TITLE: Alleviating antibiotic-induced microbiome dysfunction by quenching the microbial redox environment

STUDY_SECTION: IMII

STUDY_SECTION_NAME: Interspecies Microbial Interactions and Infectious Study Section[IMII]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Clinical Research;Pediatric;Pediatric Cancer;Prevention;Rare Diseases

ORG_CITY: Oakland

ORG_NAME: KAISER FOUNDATION RESEARCH INSTITUTE

ORG_STATE: CA

PI_NAMEs: KUSHI, LAWRENCE H (contact)

PROGRAM_OFFICER_NAME: MOLLICA, MICHELLE A

PROJECT_TERMS: Adolescent and Young Adult;Adolescent and young adult cancer patients;Advocacy;Agreement;American Cancer Society;Ancillary Study;Area;Biometry;Budgets;California;Cancer Survivor;Cancer Survivorship;Caregivers;Clinical;clinical care;Committee Members;Committee Membership;Communication;Communities;Contracts;Dana-Farber Cancer Institute;Data;data acquisition;Data Analyses;data resource;Development;Disparate;Ensure;experience;Financial Hardship;Growth;Health;Healthcare;Hospitals;Individual;insight;Institution;Institutional Review Boards;interest;Leadership;Los Angeles;Malignant Neoplasms;Manuscripts;member;Methods;Michigan;Modification;North Carolina;organizational structure;patient engagement;Patients;Pediatric Hospitals;Population;Principal Investigator;programs;Provider;psychosocial;Publications;Quality of life;Research;Research Personnel;Resource Allocation;Resource Sharing;Resources;Robin bird;Saint Jude Children's Research Hospital;Site;Source;Surveys;Survivors;synergism;timeline;Universities;Washington;Work

PROJECT_TITLE: Core A: Administrative Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Brain Disorders;Cancer;Clinical Research;Colorectal Cancer;Dementia;Digestive Diseases;Prevention

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PI_NAMEs: WARNER, ERICA T (contact)

PROGRAM_OFFICER_NAME: UMAR, ASAD

PROJECT_TERMS: Accounting;Address;Adult;Age;aged;Aged, 80 and over;aging biomarker;aging related disease;Alzheimer's disease related dementia;arm;Aspirin;Benefits and Risks;Biologic Characteristic;Biological;Biological Markers;cancer risk;Cardiovascular Diseases;cardiovascular disorder prevention;cardiovascular disorder risk;Cessation of life;Characteristics;Chronology;Clinical;cohort;Colorectal Cancer;colorectal cancer screening;Data;Dementia;dementia risk;Diabetes Mellitus;disability;disorder risk;Dose;Elderly;Epigenetic age;Equilibrium;Ethnic Origin;Evaluation;Event;experience;follow-up;frailty;Future;Gastrointestinal Hemorrhage;Guidelines;gut microbiome;Health Benefit;Hematopoiesis;Hemorrhage;high risk;high risk population;human old age (65+);improved;Incidence;indexing;Individual;Inflammatory;Life Style;Long-Term Effects;Machine Learning;Malignant Neoplasms;Modeling;Molecular;mortality;novel;older adult;Participant;personalized approach;Positioning Attribute;Predictive Factor;Preventive;Primary Prevention;Race;Randomized;randomized, clinical trials;Recommendation;Research;Risk;Risk Factors;risk prediction;risk prediction model;risk stratification;Safety;Screening for cancer;sex;social;socioeconomics;Subgroup;Testing;United States Preventative Services Task Force;Update;Work

PROJECT_TITLE: Aspirins legacy on cancer and overall benefit: risk balance over a 15-year horizon


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: BOCA RATON

ORG_DEPT: CHEMISTRY

ORG_NAME: FLORIDA ATLANTIC UNIVERSITY

ORG_STATE: FL

PHR: NARRATIVE Thiol groups can undergo numerous modifications, making cysteine a unique molecular switch. Cysteine plays structural and regulatory roles as part of proteins or glutathione, contributing to maintain redox homeostasis and regulate signaling within and amongst cells. Not surprisingly therefore, cysteines are associated with many he- reditary and acquired diseases – the research described herein will elucidate regulatory functions performed by protein cysteine residues and provide a framework for understanding how mutation and/or (in)activation of this key amino acid can cause disease.

PI_NAMEs: CARROLL, KATE SUZANNE (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TITLE: Chemical Tools for Probing Cysteine Sulfenation and Sulfination Redox Biology

STUDY_SECTION: SBCB

STUDY_SECTION_NAME: Synthetic and Biological Chemistry B Study Section[SBCB]


ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PI_NAMEs: HAAKE, DAVID A (contact)

PROGRAM_OFFICER_NAME: MUKHOPADHYAY, SUMAN


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Aging;Arthritis;Autoimmune Disease;Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Emerging Infectious Diseases;Infectious Diseases;Orphan Drug;Pain Research;Rare Diseases;Vector-Borne Diseases

ORG_CITY: WASHINGTON

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: GEORGE WASHINGTON UNIVERSITY

ORG_STATE: DC

PHR: NARRATIVE The objective of this proposal is to determine the efficacy and histopathologic effects on synovitis of 6 months of methotrexate (n=100) versus placebo (n=50) therapy for chronic CHIKV arthritis in Colombia in a randomized controlled trial. Our central hypothesis is that methotrexate will significantly decrease chronic CHIKV arthritis disease severity compared to placebo and suppress leukocyte accumulation and inflammatory cytokine expression in synovial tissue. In Aim 1, we will determine the efficacy of oral methotrexate treatment versus placebo for 6 months in chronic CHIKV arthritis, in Aim 2, we will determine the effect of methotrexate on synovial inflammation by obtaining synovial biopsy samples before and after treatment in order to precisely define the role of methotrexate in the treatment of chronic CHIKV arthritis with the goal of advancing the field towards an evidence-based standard treatment.

PI_NAMEs: CHANG, AILEEN  (contact);FIRESTEIN, GARY S

PROGRAM_OFFICER_NAME: MAO, SU-YAU

PROJECT_TERMS: Affect;Aftercare;Alpha Virus;American;arm;Arthritis;ATAC-seq;Autoimmune Process;B-Lymphocytes;Biopsy;Biopsy Specimen;California;Cell Lineage;chemokine;chikungunya;chikungunya infection;Chikungunya virus;Chronic;Clinical;college;Colombia;Culicidae;cytokine;Degenerative polyarthritis;disability;Disease;Disease Outbreaks;Dose;efficacy evaluation;Evaluation;evidence base;Evidence based treatment;Folic Acid;follow-up;Gene Expression;Goals;Guidelines;Immune;Immunoassay;Immunohistochemistry;improved;Individual;Infection;Infiltration;Inflammatory;Janus kinase;kinase inhibitor;Leukocytes;Macrophage;Measures;Mediating;Methotrexate;novel;open label;Oral;Outcome;Pain;Pain Measurement;Pathogenicity;Pathologic;Patient Outcomes Assessments;patient subsets;Patients;Persons;Pharmaceutical Preparations;Placebos;primary endpoint;Proteins;Quality of life;Randomized;randomized placebo controlled trial;Randomized, Controlled Trials;Recommendation;Reporting;response;Rheumatoid Arthritis;Rheumatology;rituximab;Role;secondary endpoint;Severity of illness;single-cell RNA sequencing;standard care;Synovial Fluid;Synovitis;T-Cell Activation;T-Lymphocyte;Therapeutic;Therapeutic Agents;therapeutic target;therapeutically effective;Tissue Sample;Tissues;treatment guidelines;United States;Universities;Viral Arthritis;Work

PROJECT_TITLE: Methotrexate treatment of Arthritis caused by Chikungunya virus (MARCH): A randomized controlled trial of methotrexate versus placebo in the treatment of chronic arthritis after chikungunya infection

STUDY_SECTION: AMSC

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Clinical Trials Study Section [AMSC]


ADMINISTERING_IC: OD

FUNDING_MECHANISM: OTHERS

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Precision Medicine;Prevention

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PI_NAMEs: BASFORD, MELISSA ;GLAZER, DAVID ;HARRIS, PAUL A. (contact);PHILIPPAKIS, ANTHONY ;RODEN, DAN M

PROGRAM_OFFICER_NAME: AZUINE, ROMULADUS EMEKA

PROJECT_TERMS: All of Us Research Program;Data;data infrastructure;Disease;Goals;Health;prevent;Research;Research Personnel;Vision

PROJECT_TITLE: All of Us Research Program Data and Research Center


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Hematology;Rare Diseases;Sickle Cell Disease

ORG_CITY: ROCKVILLE

ORG_NAME: THE EMMES COMPANY, LLC

ORG_STATE: MD

PHR: No PHR

PI_NAMEs: COLEMAN-COWGER, VICTORIA HOPE (contact)

PROGRAM_OFFICER_NAME: MONDORO, TRACI

PROJECT_TERMS: Sickle Cell Anemia

PROJECT_TITLE: Sickle Cell Disease Cure Initiative (SCDC)


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

ORG_CITY: TUCSON

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: PROJECT NARRATIVE Not enough people receive the cancer screenings (such as colonoscopies and mammograms) that they need, and COVID-19 has made getting these services more difficult. Our study will examine the impacts of COVID-19 on cancer screening and follow-up care for low-income and Latinx adults served by community health centers. Our goal is to guide community health centers in recovering from COVID- 19, ensure more equitable access to cancer screening, and save lives from preventable cancers.

PI_NAMEs: CORONADO, GLORIA D (contact)

PROGRAM_OFFICER_NAME: WEAVER, SALLIE JAYNE

PROJECT_TERMS: Adult;American Cancer Society;authority;cancer diagnosis;cancer health disparity;Cancer Intervention and Surveillance Modeling Network;cancer prevention;care delivery;Caring;Centers for Population Health;Cessation of life;Clinic;Clinical;Collaborations;Colonoscopy;Colorectal Cancer;Communities;COVID-19;COVID-19 impact;COVID-19 pandemic;COVID-19 pandemic effects;Data;Data Sources;Disparity;disparity reduction;Drops;economic impact;Electronic Health Record;Eligibility Determination;Ensure;Equity;Ethnic Origin;experience;federal poverty level;Federally Qualified Health Center;follow-up;Fright;Future;Gastroenterology;Goals;health assessment;health disparity populations;Health Services;Health Services Accessibility;Health system;Hospitalization;improved;Incidence;Income;Individual;infection rate;innovation;Insurance Coverage;Interruption;Intervention;Interview;Job loss;Language;Latinx;Latinx population;Life;long term consequences of COVID-19;long term COVID-19 pandemic impacts;Long-Term Care;Long-Term Effects;Low income;Malignant Neoplasms;Mammography;Medical;medical specialties;Methods;Modeling;models and simulation;Natural Disasters;Neighborhood Health Center;Outcome;pandemic disease;pandemic impact;Pap smear;patient-level barriers;Patients;Pattern;Persons;post-COVID-19;post-pandemic;pre-pandemic;preference;prevent;Preventive care;Primary Care;Protocols documentation;Provider;Race;Recommendation;Recovery;Recovery Support;Reduce health disparities;Research;Resources;SARS-CoV-2 infection;screening;Screening for cancer;screening services;service delivery;Services;sex;Site;telehealth;trend;United States;uptake;Visit;Vulnerable Populations

PROJECT_TITLE: Assessing the long-term impacts of the COVID-19 pandemic on disparities in cancer screening and follow-up (RESTORE)

STUDY_SECTION: HSQE

STUDY_SECTION_NAME: Health Services: Quality and Effectiveness Study Section[HSQE]


ADMINISTERING_IC: DE

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

ORG_CITY: WEST LAFAYETTE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: PROJECT NARRATIVE The project will identify the optimal intermittent vibration force stimulation to control orthodontic tooth movement rate through a rat study and scale it up for other species, including dogs and humans. The relevance of this project is that, once successful, the technology will enable clinicians to shorten the treatment time with reduced side-effects. The long term goal is to translate this technology into devices that can be used c linic ally.

PI_NAMEs: CHEN, JIE  (contact)

PROGRAM_OFFICER_NAME: WAN, JASON

PROJECT_TITLE: Dose analysis for translating animal based vibrational force study for accelerating orthodontic tooth movement to clinic

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PI_NAMEs: SILVA, AFONSO C (contact)

PROGRAM_OFFICER_NAME: REFOLO, LORENZO

PROJECT_TERMS: Advisory Committees;Alzheimer's disease model;animal care;Animal Testing;Area;Bioinformatics;Breeding;Budgets;Callithrix;Communities;community engagement;Community Outreach;Data;data integration;Data Reporting;Development;Disease;Ensure;equipment acquisition;Evaluation;experimental study;Fibroblasts;Genetic Engineering;Goals;Institution;Knowledge Portal;Leadership;Measures;medical schools;meetings;Mission;Modeling;Monitor;multimodality;open data;outreach;Progress Reports;Protocols documentation;Reagent;Research;Research Personnel;Research Project Grants;Resources;Schedule;Science;success;symposium;The Jackson Laboratory;Time;United States National Institutes of Health;Universities

PROJECT_TITLE: Administrative Core


ORG_DEPT: BIOCHEMISTRY

ORG_NAME: TUFTS UNIVERSITY BOSTON

PHR: High-risk human papillomavirus infections cause cervical cancer and other genital and oropharyngeal cancers that account for nearly 5% of cancers worldwide. HPV-positive cancers are poorly differentiated and restoring differentiation in a cancer caused by HPV infection has high therapeutic potential. The goal of this proposal is to understand how the high-risk HPV E7 oncoprotein inhibits epithelial differentiation.

PI_NAMEs: WHITE, ELIZABETH A (contact)

PROGRAM_OFFICER_NAME: ALARCON, RODOLFO M

PROJECT_TITLE: Human Papillomavirus Manipulation of Epithelial Differentiation

STUDY_SECTION: VIRA

STUDY_SECTION_NAME: Virology - A Study Section[VIRA]


ORG_CITY: INDIANAPOLIS

ORG_DEPT: PEDIATRICS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

PHR: PROJECT NARRATIVE Intermittent fasting and caloric restriction are newly identified, effective means through to treat secondary cardiomyopathies. We identified trehalose-class compounds as pharmacological mimetics of the adaptive fasting response, which also attenuate the pathological growth, gene expression and cardiac dysfunction that is induced by chronic pressure overload. Using broad cardiomyopathic stimuli and detailed mouse genetic approaches in the current proposal, we will examine signaling mechanisms and clinical contexts in which hepatic glucose fasting responses can be leveraged against secondary cardiomyopathies.

PI_NAMEs: DEBOSCH, BRIAN JESSE (contact)

PROGRAM_OFFICER_NAME: SOPKO, GEORGE

PROJECT_TITLE: Treating secondary cardiomyopathies by mimicking the adaptive hepatic glucose fasting response

STUDY_SECTION: MIM

STUDY_SECTION_NAME: Myocardial Ischemia and Metabolism Study Section[MIM]


FUNDING_MECHANISM: RESEARCH CENTERS

NIH_SPENDING_CATS: Breast Cancer;Cancer;Cancer Genomics;Genetics;Human Genome;Lung;Women's Health Research

ORG_CITY: NEW YORK

ORG_NAME: ROCKEFELLER UNIVERSITY

ORG_STATE: NY

PHR: The MetNet Center for Systems-level Study of Metastasis will elucidate how dynamic interactions between neuronal cells, localized lymphatics, metabolites and cancer cells collectively contribute to the emergence of metastatic disease - thereby identifying critical genes as therapeutic targets for its eradication.

PI_NAMEs: BIRSOY, KIVANC  (contact)

PROGRAM_OFFICER_NAME: GRIL, BRUNILDE M

PROJECT_TERMS: Address;Breast Cancer Cell;breast cancer metastasis;cancer cell;cancer heterogeneity;Cancer Model;Cell Communication;cell type;Cells;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Computational Biology;CRISPR screen;Dependence;Disease;Distant;Environment;extracellular;Extracellular Matrix;gain of function;Gene Expression Profile;Genes;Genetic;Liver;loss of function;lung colonization;Lymphatic;Maps;Metabolic;Metabolism;metabolomics;Metastatic Neoplasm to the Lung;Modeling;Molecular;multidisciplinary;Neoplasm Circulating Cells;Neoplasm Metastasis;neoplastic cell;Neurons;Normal Cell;Nutrient;Nutrient availability;Organ;Oxygen;Pathway interactions;Population;Process;programs;Repression;Role;single cell sequencing;Site;Starvation;System;Techniques;Testing;Therapeutic;therapeutic target;transcriptomics;treatment response;tumor;tumor metabolism;Work

PROJECT_TITLE: Project 3: The role of microenvironmental metabolites on metastatic progression


PHR: Project Narrative Heart failure with preserved ejection fraction (HFpEF) is an unmet need in modern medicine, and is associated with comorbidities like obesity, diabetes, and hypertension. HFpEF is characterized by pronounced coronary microvascular dysfunction (CMD), but the causal contribution of CMD is not clear. The current proposal is to study the impact of CMD on the cardiac function and remodeling in HFpEF and will test the hypothetical benefit of miR-21 deletion on maintaining the coronary microvascular function, myocardial blood flow and cardiac function in HFpEF using global and tissue-specific miR-21 knockout and lineage tracing mice.

PI_NAMEs: YIN, LIYA  (contact)

PROGRAM_OFFICER_NAME: ADHIKARI, BISHOW B

PROJECT_TERMS: 3-Dimensional;Ablation;Acetylcholine;Address;Adult;Aging;angiogenesis;Animal Model;Apoptosis;arteriole;Biology;Blood capillaries;Blood flow;Blood Vessels;Cardiac;cardiac vasculature;Cardiovascular system;cell type;Cells;Chronic;clinical heterogeneity;comorbidity;Consensus;constriction;Contrast Echocardiography;Coronary;Coronary Arteriosclerosis;Coronary artery;coronary fibrosis;Coronary Vessels;Correlation Studies;Data;density;Development;Diabetes Mellitus;diabetic cardiomyopathy;Diabetic mouse;Diet;Dilator;Discipline;Echocardiography;EFRAC;endothelial dysfunction;Endothelium;Exhibits;Extravasation;Fatty acid glycerol esters;Fibrosis;fluorescence imaging;Functional disorder;Genetic;Heart;Heart failure;heart function;Homeostasis;Human;Hydrogen Peroxide;Hypertension;Impairment;improved;in vivo;indexing;insight;interdisciplinary approach;Intervention;Ischemia;Knock-out;Measurement;Mediating;Mediator;Mesenchymal;Metabolic stress;Microcirculation;MicroRNAs;Microvascular Dysfunction;Modern Medicine;Molecular;mortality;mouse model;Mus;Myocardial;Myocardial dysfunction;Myocardial Ischemia;Myocardial perfusion;Myocardium;novel;Nutrient;Obesity;Oxygen;Pathogenicity;Patients;Perfusion;Permeability;pharmacologic;Phenocopy;Phenotype;Physiology;Play;pre-clinical;preservation;pressure;prevent;Prognosis;Proliferating;Regulation;Relaxation;Reperfusion Injury;Reporting;restoration;Role;single-cell RNA sequencing;sugar;Symptoms;Testing;Therapeutic;therapeutic target;Time;Tissues;transcriptome sequencing;United States;Vasodilation

PROJECT_TITLE: Disruption of the Cardiac-Coronary Axis as a Mechanism of HFpEF

STUDY_SECTION: MPPA

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology A Study Section [MPPA]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Brain Disorders;Chronic Liver Disease and Cirrhosis;Complementary and Integrative Health;Dietary Supplements;Digestive Diseases;Liver Disease;Natural Products;Neurosciences;Nutrition;Prevention;Substance Misuse;Substance Misuse Prevention

PI_NAMEs: SONG, BYOUNG-JOON  (contact)

PROJECT_TERMS: Acetaldehyde;Acetaminophen;Acetylation;Actins;Acute;acute liver injury;adduct;Adherens Junction;Affect;Aftercare;Age;age related neurodegeneration;Albumins;alcohol exposure;alcohol prevention;Alcohols;aldehyde dehydrogenases;Aldehydes;animal tissue;antioxidant enzyme;Antioxidants;Apoptosis;Award;Basic Science;Biochemical;Brain;Brain Injuries;Carbon Tetrachloride;CASP3 gene;cell injury;Cells;Cessation of life;Cisplatin;Collaborations;Collagen;confocal imaging;Cultured Cells;CYP2E1 gene;cytokine;Diabetes Mellitus;dietary;dietary supplements;Disease;disease model;Dose;drinking water;Ellagic Acid;Endoplasmic Reticulum;endoplasmic reticulum stress;Endotoxemia;Endotoxins;Enzymes;Epithelial Cells;Ethanol;Ethanol Metabolism;Excision;Exposure to;extracellular;Fatty acid glycerol esters;Fibrosis;Fructose;Functional disorder;Future;Gene Expression Regulation;Ginseng Preparation;Goals;gut-liver axis;Hepatic;Hepatocyte;Hepatotoxicity;High Fat Diet;Histology;HIV-1;Immunoblot Analysis;In Situ Nick-End Labeling;Inflammatory;Injections;Injury;intestinal barrier;intestinal epithelium;Intestines;Juglans;Knockout Mice;Leaky Gut;Lipid Peroxides;Lipopolysaccharides;Liver;Liver diseases;Liver Fibrosis;liver injury;Malnutrition;Manuscripts;MAP Kinase Gene;Mediating;Melatonin;member;Metabolic syndrome;Metabolism;Methods;Mitochondria;mitochondrial dysfunction;Mitochondrial Proteins;Modeling;Molecular;Mus;nanocarrier;nanosized;nanovesicle;NF-kappa B;Nicotine;nitration;non-alcoholic;non-alcoholic fatty liver disease;Nuclear Proteins;Obesity;Oral Administration;Organ;organ injury;Organelles;oxidation;Oxidative Stress;Pathologic;Pathway interactions;Pattern;permissiveness;Phosphorylation;Physiological;Plant Preparations;Plants;Poison;Pomegranate;Post-Translational Protein Processing;pre-clinical research;prevent;Protective Agents;Protein Acetylation;protein biomarkers;Proteins;Proteolysis;Publications;Publishing;Rat Transgene;Rattus;Reactive Oxygen Species;Reperfusion Injury;Reporting;research and development;research study;Resistance;Risk Factors;Rodent;Role;Serum;Severities;sex;Signal Pathway;Signal Transduction;Sirius Red F3B;SIRT1 gene;Smooth Muscle;Sodium Dextran Sulfate;Stains;Stress;Thioacetamide;Tight Junctions;Time;tissue injury;Tissues;TP53 gene;Translational Research;Ubiquitin;United States National Institutes of Health;Vimentin;virtual;Virus Diseases;Wild Type Mouse

PROJECT_TITLE: Alcohol Metabolism, Functional Consequences and Apoptosis Signaling Mechanism


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Mental Health;Neurosciences;Substance Misuse

ORG_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

PI_NAMEs: MOMENAN, REZA  (contact)

PROJECT_TERMS: alcohol abuse therapy;alcohol cue;alcohol use disorder;Alcoholic Beverages;Alcohols;Amygdaloid structure;antisocial behavior;Arousal;Attention;attentional bias;Awareness;Behavior;Beverages;Categories;Clinical;Cognition;Cognitive;combat;coping;craving;Cues;Data Analyses;Decision Making;Development;discounting;Disease;efficacy evaluation;emotion dysregulation;Emotional;Emotions;executive function;Fortune;Functional Magnetic Resonance Imaging;functional MRI scan;functional near infrared spectroscopy;Image;Impairment;Impulsivity;Journals;Learning;Maintenance;Manuscripts;Memory;Morals;Motivation;negative affect;neural;neural correlate;novel;Outcome;Participant;Patient Recruitments;Patients;Perception;Play;Predisposition;Publications;Regrets;resilience;Rewards;Risk;Role;social neuroscience;social stigma;Stimulus;Stress;Structure of middle temporal gyrus;Structure of supramarginal gyrus;substance use

PROJECT_TITLE: fMRI study of cognition, motivation, decision-making, reward, risk, aversion, negative emotion, arousal, craving, impulsivity, and stress in alcohol use disorder


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Neurosciences;Precision Medicine;Substance Misuse;Tobacco

PROJECT_TERMS: Abstinence;acamprosate;Adult;Affect;Age;Alcohol consumption;alcohol effect;alcohol use disorder;Amygdaloid structure;Appearance;Area;Bacteria;Bacteroides;Bayesian Modeling;Behavioral;Biological;Biological Markers;Body mass index;Brain;Brain Diseases;Brain region;Butyrates;Calibration;Childhood;Cigarette;Classification;Clinical;cognitive function;Collaborations;comorbidity;Complex;cost;Data;Data Analyses;Development;Disease;disorder subtype;Double-Blind Method;drinking;drug misuse;early life stress;Electroencephalography;Emotional;Emotions;Encapsulated;Escherichia coli;executive function;experience;FDA approved;Functional disorder;Functional Magnetic Resonance Imaging;gamma-Aminobutyric Acid;Glutamates;Goals;gut microbiome;Image;improved;Individual;Inpatients;insight;Institutional Review Boards;Intention;Journals;Laboratories;large scale data;Link;Longevity;Magnetic Resonance Imaging;Manuscripts;marijuana use disorder;Mental disorders;mental state;Metabolism;morphometry;Motor;neural;Neurobiology;neuroimaging;neuromechanism;neuropsychopharmacology;nicotine use;nicotine user;non-smoker;Obesity;opioid use disorder;Outcome;Participant;Pathologic;Patients;personalized medicine;Pharmaceutical Preparations;Phenotype;Pilot Projects;Placebos;Play;polygenic risk score;Population Intervention;Prediction of Response to Therapy;Prevotella;Probability;Process;Protocols documentation;psychological distress;psychological symptom;Psychopathology;Publications;Publishing;Recording of previous events;Recovery;Relapse;Research;Rest;Risk;Role;Ruminococcus;Sample Size;Science;Sensory;Shapes;Social support;somatosensory;Substance Use Disorder;substance user;Symptoms;temporal measurement;Testing;Time;tool;Trauma;Treatment Efficacy;Variant;Visual;white matter;Work

PROJECT_TITLE: Neuroimaging of Alcohol Use Disorder


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Substance Misuse

PROJECT_TERMS: Affect;Alcohol consumption;alcohol craving;alcohol measurement;alcohol use disorder;Alcohols;Anterior;Area;Behavioral;Beverages;Bilateral;Brain;Brain region;caudate nucleus;Cephalic;cingulate cortex;cingulate gyrus;Cities;college;comorbidity;Control Groups;craving;Cues;Data;Data Analyses;Desire for food;Double-Blind Method;emotion regulation;Exhibits;Feedback;follow-up;Food;food craving;Functional Magnetic Resonance Imaging;Image;Impulsivity;Individual;Inpatients;Insula of Reil;Left;neural;neurofeedback;Neurons;neurophysiology;neuroregulation;New York;Outcome;Pain;Participant;Patient Self-Report;Pattern;Phase II Clinical Trials;Placebo Control;Precentral gyrus;Protocols documentation;putamen;Randomized;Regulation;repetitive transcranial magnetic stimulation;response;Rewards;somatosensory;success;Superior temporal gyrus;symposium;Time;Ventral Striatum;visual processing

PROJECT_TITLE: Neuromodulation Applications in Alcohol Use Disorder