ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE (Public Heath relevance) The results of this investigation will provide a detailed understanding of the mechanisms regulating the motion of the CSF and the transport of all-important molecules along the spinal canal key to the functioning of the Central Nervous System (CNS). It accounts for the patient-specific anatomy and physiological conditions. It will also develop the modeling methodology necessary to optimize Intrathecal Drug Delivery (ITDD) protocols for the administration of potent analgesic agents for the amelioration of severe and chronic pain.

PI_NAMEs: SANCHEZ, ANTONIO LUIS (contact)

PROGRAM_OFFICER_NAME: MORRIS, JILL A

PROJECT_TERMS: Acid-Base Equilibrium;Affect;Analgesics;Anatomy;Bathing;Brain;bulk motion;Central Nervous System;Cerebrospinal Fluid;cerebrospinal fluid flow;Characteristics;chemotherapy;chronic pain;Circulation;Clinical;Cognition Disorders;Development;Diffusion;Drug Delivery Systems;Drug Kinetics;Drug Transport;Equilibrium;Excision;experience;Formulation;Heart;Hormones;In Vitro;in vivo;Injections;Intracranial Pressure;Investigation;Liquid substance;Location;Lymphatic System;Malignant neoplasm of central nervous system;mathematical model;Measurement;Metabolism;Methodology;Modeling;Molecular;Motion;multidisciplinary;Nervous System Disorder;Neuroglia;Neurons;Neuropeptides;Neurotransmitters;novel;Nutrient;Outcome;particle;Pathology;patient response;Patients;Pharmaceutical Preparations;Physiological;Plasma;Positioning Attribute;Posture;Procedures;Protocol Compliance;Protocols documentation;public health relevance;Radiology Specialty;release factor;Research;respiratory;Rotation;solute;Spinal;Spinal Canal;Spinal Cord;Stream;Subarachnoid Space;Surface;Time;Validation;Variant;Waste Products

PROJECT_TITLE: Development of Patient-Specific Mathematical Models for the Transport of Solute Molecules in the Cerebrospinal Fluid (CSF) Along the Spinal Canal

STUDY_SECTION: MABS

STUDY_SECTION_NAME: Modeling and Analysis of Biological Systems Study Section[MABS]


ADMINISTERING_IC: HL

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Aging;Cardiovascular;Clinical Research;Contraception/Reproduction;Heart Disease;Hypertension;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Women's Health Research

ORG_CITY: BIRMINGHAM

ORG_COUNTRY: UNITED STATES

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Project Narrative This follow-up study of the well-characterized CHAP cohort will define the impact of preeclampsia and antihypertensive treatment during pregnancy on long-term risk for maternal cardiovascular outcomes and assess the predictive role of factors included in the ASCVD risk score for women aged <40 years. These results will help identify optimal blood pressure preventive strategies to enhance the long-term health of reproductive-aged women with CHTN.

PI_NAMEs: OPARIL, SUZANNE ;SZYCHOWSKI, JEFF M;TITA, ALAN THEVENET N. (contact)

PROGRAM_OFFICER_NAME: REID, DIANE M

PROJECT_TERMS: Address;adjudication;adverse outcome;Affect;Age;aged;American College of Obstetricians and Gynecologists;Anti-Hypertensive Agents;Atherosclerosis;Biological;Biological Markers;Birth Weight;Blood;Blood Pressure;Cardiovascular Diseases;cardiovascular disorder risk;Cardiovascular system;Cessation of life;Child;Chronic;Classification;cognitive function;cohort;Coronary heart disease;Country;Data;design;Development;Diabetes Mellitus;Discipline of obstetrics;Disease;Disease Outcome;Early treatment;Enrollment;Ethnic Origin;fetal;Fetal Growth Retardation;follow-up;Follow-Up Studies;Frequencies;Future;General Population;Goals;Health;Heart failure;Hypertension;improved;indexing;International;Kidney Failure;Knowledge;Lipids;Long-Term Effects;Maternal Health;maternal risk;Medical;Medical Records;Morbidity - disease rate;Myocardial Infarction;National Heart, Lung, and Blood Institute;National Institute of Child Health and Human Development;Newborn Infant;Non-Insulin-Dependent Diabetes Mellitus;offspring;optimal treatments;Outcome;Outcome Study;Participant;Perinatal;Persons;Pharmacological Treatment;Population;post pregnancy;Postpartum Period;Pre-Eclampsia;Pregnancy;Pregnant Women;Premature Birth;prepregnancy;Prevention strategy;primary outcome;Professional Organizations;prospective;Questionnaires;Race;Randomized;Recommendation;Recording of previous events;reproductive;Reproductive Health;Risk;Risk Factors;Risk Marker;Risk Reduction;Role;Safety;Site;Small for Gestational Age Infant;Smoking Status;Stroke;Testing;tool;Uncertainty;Urine;venous thromboembolism;Visit;Woman

PROJECT_TITLE: Pregnancy as a Window to the Future: Outcomes of Antihypertensive Therapy and Superimposed Preeclampsia in Pregnant Women with Mild Chronic Hypertension (CHAP Maternal Follow-up Study)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-N(02)]


ED_INST_TYPE: GRADUATE SCHOOLS

ORG_CITY: BERKELEY

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

ORG_STATE: CA

PHR: NARRATIVE Human genome engineering has widely anticipated promise as a healthcare strategy, but technologies in development are unlikely to safely or efficiently introduce a gene into the human genome. Starkly missing from transgene introduction strategies is an approach based on what is already quite successful across eukaryotic evolution: gene insertion by synthesis of an RNA-templated complementary DNA (cDNA). The evolutionary success of RNA template-specific, DNA site-specific LINE/non-LTR retroelement insertion begs to be engineered to develop a transgene introduction technology for human gene therapy.

PI_NAMEs: COLLINS, KATHLEEN  (contact)

PROGRAM_OFFICER_NAME: QASBA, PANKAJ

PROJECT_TERMS: 3' Untranslated Regions;5' Flanking Region;Architecture;Biochemical;Capsid;Cell Cycle;Cell Proliferation;cell type;Cells;Clinical;Complementary DNA;CRISPR/Cas technology;Dependovirus;Development;Disease;DNA;DNA biosynthesis;DNA delivery;Engineering;Eukaryota;Evolution;Failure;Family;gene therapy;Genes;Genome;Genome engineering;Goals;Healthcare;high risk;homologous recombination;Human;Human Genetics;Human Genome;innovation;interest;loss of function;Modality;non-Native;Outcome;Pathology;Phase;Positioning Attribute;protein expression;Protein Isoforms;Proteins;repaired;Repetitive Sequence;Retroelements;Reverse Transcription;RNA;RNA chemical synthesis;RNA Sequences;Site;Specificity;success;Supplementation;Techniques;Technology;Therapeutic;Transcript;Transgenes;uptake;Virus

PROJECT_TITLE: Human genetic supplementation without donor DNA or a DNA break


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: COLD SPRING HARBOR

ORG_NAME: COLD SPRING HARBOR LABORATORY

ORG_STATE: NY

PHR: The central goal of this research is to deﬁne genes and principles that convert indolent prostate cancer into lethal metastatic disease. We use three separate approaches towards this goal: in Aim 1, we reveal, isolate, and analyze single pioneer cells in space and time, in Aim 2, we address the PTEN co-mutation impasse and deﬁne genes co-deleted with PTEN, and in Aim 3, we develop two new modeling platforms for more ﬂexible validation of candidate genes and principles.

PI_NAMEs: TROTMAN, LLOYD C (contact)

PROGRAM_OFFICER_NAME: BENAVIDEZ, JUSTIN MICHAEL

PROJECT_TERMS: 3-Dimensional;Acceleration;Address;Age;Animals;Anti-androgen Therapy;Armenia;Autopsy;Back;Body part;Breeding;Candidate Disease Gene;candidate validation;Castration;Cell Culture Techniques;Cell Separation;cell type;Cells;cellular imaging;Cessation of life;clinically significant;Collaborations;CRISPR/Cas technology;Dependence;Development;Diagnosis;Disease;Dreams;Event;flexibility;Frequencies;Gene Deletion;Gene Mutation;Generations;Genes;Genetic;Genetically Engineered Mouse;genome analysis;genome sequencing;Goals;Histologic;Human;Image;imaging platform;Immunocompetent;In Vitro;in vivo;in vivo Model;Indolent;International;lead candidate;Lentivirus Vector;Life;male;Malignant neoplasm of prostate;Malignant Neoplasms;Maps;men;Metastatic Prostate Cancer;Microscopy;Modeling;Molecular;Molecular Probes;Mus;mutant;Mutate;Mutation;Nature;Neoplasm Metastasis;neoplastic cell;Newly Diagnosed;Nude Mice;Oncogenes;Organ;Organoids;Pathway interactions;Patients;Penetrance;pharmacologic;Phenotype;Phosphotransferases;PIK3CG gene;Positioning Attribute;programs;Prostate;prostate cancer model;Proxy;PTEN gene;Receptor Protein-Tyrosine Kinases;Recurrent disease;Relapse;Reporting;Research;Resistance;Resolution;Role;Sampling;Signal Transduction;single cell analysis;Site;standard of care;Survivors;System;Techniques;Testing;Therapeutic;Three-Dimensional Imaging;Time;tomography;TP53 gene;Transplantation;tumor;tumor diagnosis;two-photon;upstream kinase;Validation;Washington;whole genome

PROJECT_TITLE: Metastasis of PTEN Mutant Prostate Cancer

STUDY_SECTION: TPM

STUDY_SECTION_NAME: Tumor Progression and Metastasis Study Section[TPM]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Hematology;Infectious Diseases;Patient Safety;Pediatric;Prevention;Sepsis

ORG_CITY: LITTLE ROCK

ORG_NAME: ARKANSAS CHILDREN'S HOSPITAL RES INST

ORG_STATE: AR

PHR: NARRATIVE Invasive candidiasis is the most common form of invasive fungal disease. Prospective observational and randomized trials in children and adults have confirmed echinocandins as the antifungal of choice for primary treatment of candidemia. However, while 14 days of therapy is recommended, the optimal duration of therapy for candidemia remains unknown. The primary objective of the proposed randomized trial is to determine if 7 days of therapy is comparable to 14 days for for pediatric uncomplicated candidemia and if a molecular biomarker can provide supportive data for short course therapy.

PI_NAMEs: FISHER, BRIAN T;STEINBACH, WILLIAM J (contact)

PROGRAM_OFFICER_NAME: LOVE, DONA

PROJECT_TERMS: Adult;Anti-Bacterial Agents;anti-fungal agents;Anti-Infective Agents;Antifungal Therapy;arm;Automobile Driving;Bacteremia;Bacterial Infections;Benefits and Risks;Biological Assay;Biological Markers;biomarker performance;Blood;Candida;candidemia;Candidiasis;Child;Childhood;Clinical;clinical epidemiology;Communicable Diseases;Communities;comparative effectiveness study;Comparative Study;Complication;Data;Dedications;design;Disease;Drug Interactions;Early Diagnosis;effective therapy;Effectiveness;Expert Opinion;Fluconazole;Foundations;Funding;Future;Guidelines;Human Resources;improved;improved outcome;Infection;International;Knowledge;Laboratories;Length of Stay;Measures;Methodology;Molds;molecular marker;Morbidity - disease rate;mortality;Multicenter Studies;multidisciplinary;Mycoses;novel;novel marker;observational cohort study;Observational Study;optimal treatments;Otitis Media;Outcome;Outcome Measure;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;Pneumonia;prospective;Prospective Studies;Publishing;Randomized;randomized trial;randomized, clinical trials;Randomized, Controlled Trials;rapid diagnosis;Recommendation;Research;Research Personnel;Resolution;response;Site;Societies;standard of care;therapy duration;United States National Institutes of Health;Update;Urinary tract infection;Yeasts

PROJECT_TITLE: Short Course Versus Standard Course Antifungal Therapy for Pediatric Candidemia: A Multi-Center Randomized Controlled Trial


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Emerging Infectious Diseases;Hematology;Infectious Diseases;Liver Disease;Rare Diseases;Vector-Borne Diseases

ORG_CITY: MADISON

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE Yellow fever results in approximately 200,000 cases and 30,000 deaths per year in South-Central America and Sub-Saharan Africa, with increasing potential for spread to Asia, Oceania, North America, and Europe. Death from yellow fever is correlated with liver damage and the development of hemorrhagic disease; however, the mechanisms underlying these disease processes have not been defined. In this study, we will identify key aspects of yellow fever disease progression that culminate in liver damage and hemorrhagic disease, leading to a better understanding of the disease and how it might be treated.

PI_NAMEs: BAILEY, ADAM LEE (contact)

PROGRAM_OFFICER_NAME: MILLER, BECKY

PROJECT_TERMS: Achievement;Adverse event;Aedes;Africa South of the Sahara;animal facility;Animal Model;Animals;Applications Grants;Asia;Award;Basic Science;Benign;Biological;Biological Assay;Bite;Blood Coagulation Disorders;Blood Coagulation Factor;Blood specimen;career;Cell Line;cell type;Cells;Central America;Cessation of life;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Coagulation Process;combat;Complement;Consumption;CRISPR/Cas technology;Culicidae;Data;Development;Disasters;Disease;Disease Progression;disease transmission;Doctor of Philosophy;Engraftment;Environment;Europe;Event;Funding Mechanisms;Generations;Genes;genome-wide;Hemorrhage;Hepatocyte;high reward;high risk;HRK gene;Human;human pathogen;Immune;improved;In Vitro;Infection;Infectious Diseases Research;insight;Institution;Integration Host Factors;Interferons;invention;Knock-out;knockout gene;Kupffer Cells;Laboratories;Laboratory Research;large scale production;Leadership;Life Cycle Stages;Liver;liver injury;Macaca;Mediating;Modeling;Molecular;mouse model;Mus;Myeloid Cells;Natural Resistance;neglect;nonhuman primate;North America;novel;Oceania;Organ;Pathogenesis;Pathology;Patients;Persons;Physicians;Play;Population;Positioning Attribute;Predisposition;Primates;Principal Investigator;Process;Production;professor;programs;Public Health;Public Speaking;Research;Research Personnel;Resistance;Risk;Role;Science;Scientific Inquiry;Scientist;skills;Southeastern Asia;Specimen;Statistical Data Interpretation;Study models;success;System;Technology;tenure track;Testing;Time;Tissues;tool;Transgenic Mice;Transplantation;Tropism;United States National Institutes of Health;Universities;Utah;vector mosquito;Viral;Viral Hemorrhagic Fevers;virology;Virus Replication;whole genome;Work;Writing;Xenograft procedure;Yellow Fever;Yellow Fever Vaccine;Yellow fever virus;Yellow Fever Virus Infection

PROJECT_TITLE: Determinants of yellow fever pathogenesis in humans

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-H(70)R]


ADMINISTERING_IC: NS

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Neurosciences;Substance Misuse

ORG_CITY: EL CERRITO

ORG_NAME: MAGNETIC TIDES, INC.

PHR: Project Narrative We have recently developed a new non-invasive brain stimulation (NIBS) system, kilohertz transcranial magnetic perturbation (kTMP) that opens up a new experimental space for safely modulating neural excitability in targeted areas of the human brain. This project will characterize the broad parameter space of kTMP in terms of tolerability and efficacy in healthy individuals. The results from this work will set the stage for full-fledged clinical trials in patients with neurological disorders such as stroke or spinal cord injury, two areas in which NIBS methods show promise as tools to facilitate neurorehabilitation.

PI_NAMEs: LABRUNA, LUDOVICA  (contact)

PROGRAM_OFFICER_NAME: CAPORELLO, EMILY LAURA

PROJECT_TERMS: Acoustics;Amplifiers;Area;Auditory;Basic Science;Behavior;Behavioral;Behavioral Assay;Brain;Cephalic;clinical application;Clinical Trials;cognitive neuroscience;Communities;Coupling;design;Detection;Devices;Double-Blind Method;Earplug;efficacy evaluation;electric field;Electric Stimulation;Electroencephalography;expectation;experimental study;falls;flexibility;Frequencies;Funding;Goals;Grant;Human;Individual;Institution;Institutional Review Boards;interest;Intervention;Lead;Learning;Literature;magnetic field;Magnetism;Measures;Membrane Potentials;Mental Depression;Methods;Motor Cortex;Motor Evoked Potentials;Nervous System Disorder;neural;Neurologic;neurological rehabilitation;Neurons;noninvasive brain stimulation;Occipital lobe;Pain;Participant;Patients;Physiologic pulse;Physiological;Physiology;Pilot Projects;Population;Protocols documentation;Rest;Risk;Safety;Scalp structure;Sensory;Signal Transduction;sound;Specificity;Spinal cord injury;Stroke;stroke rehabilitation;stroke therapy;Surface;Syncope;System;Tactile;Testing;Time;tool;Transcranial magnetic stimulation;translational applications;vibration;voltage;Work

PROJECT_TITLE: Exploring the Parameter Space of High Frequency Magnetic Perturbation in Manipulating Neural Excitability and Plasticity.


ORG_CITY: STANFORD

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE The Stanford Ellison Longitudinal Aging (SELA) cohort is a unique resource offering unprecedented opportunity to understand immune-aging. The cohort’s relation to general physiology, its expansion through continued sampling, expanded age coverage and additional data types oriented on understanding driving mechanisms of immune-changes with age and the clinical implication of these changes is bound to bring important insights difficult to achieve in any other cohort. The team assembled is world-class, has been building this resource for 12 years, and has repeatedly delivered breakthrough science.

PI_NAMEs: DAVIS, MARK MORRIS (contact)

PROGRAM_OFFICER_NAME: PRABHUDAS, MERCY R

PROJECT_TERMS: active lifestyle;Acute;adaptive immune response;Address;Age;age difference;age related;age related changes;Aging;Alzheimer's Disease;Antibodies;Antigens;Automobile Driving;B-Lymphocytes;Binding;Biological Aging;Biological Clocks;Blood Cells;cancer risk;Cardiovascular Diseases;Cardiovascular system;Cells;Chronic;Chronology;Clinical;clinical prognostic;clinical risk;cohort;Communicable Diseases;Coupled;Cross-Sectional Studies;cytokine;Data;design;Deterioration;Development;Disease;disorder risk;Dizygotic Twins;dynamic system;Early Diagnosis;Epidemiology;Epigenetic Process;flu;Foundations;Future;Gene Expression;Heart Transplantation;high dimensionality;high throughput screening;Human;Immune;immune function;Immune response;Immune system;Immunologic Monitoring;Immunologics;Immunology;Individual;individual variation;Inflammation;Influenza vaccination;influenza virus strain;influenza virus vaccine;insight;Length;lens;Life Style;Link;Longitudinal Studies;Maps;Measures;member;Methods;middle age;Molecular;Morbidity - disease rate;mortality;Nature;novel;older adult;Older Population;Parkinson Disease;Pattern;Phenotype;Physiological;Physiology;Populations at Risk;predictive marker;Premature aging syndrome;Process;Publishing;rate of aging;Recording of previous events;recruit;Registries;Research;research clinical testing;Research Project Grants;Resolution;Resources;response;Risk Factors;Sampling;Science;seasonal influenza;Serum;Severity of illness;ST14 gene;Standardization;Strenuous Exercise;System;T cell response;T-cell receptor repertoire;Testing;Therapeutic;Time;Twin Multiple Birth;Vaccination;vaccine response;Variant;Whole Blood;Women's Health;Work

PROJECT_TITLE: High resolution longitudinal immune monitoring for elucidating immune aging dynamics


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Digestive Diseases;Nutrition

ORG_DEPT: BIOPHYSICS

PHR: PROJECT NARRATIVE Many adult organs, including the intestine, grow and shrink repeatedly across an animal’s lifetime to respond to its dynamic functional needs. During physiological shrinkage, live cells are purged out of the tissue (extrusion) and stem cells are culled, yet we know virtually nothing about the mechanisms that underlie these size- controlling behaviors. Here, we will leverage powerful live imaging and analysis methods developed by my lab to address fundamental questions about cell extrusion and stem cell behaviors during intestinal shrinkage; the knowledge we generate will create a conceptual framework that will inform vertebrate and possibly human studies of the intestine in both health and disease.

PI_NAMEs: O'BRIEN, LUCY ERIN (contact)

PROGRAM_OFFICER_NAME: GREENWEL, PATRICIA

PROJECT_TERMS: Address;Adopted;Adult;Anatomy;Animals;Apoptosis;Apoptotic;Behavior;Behavior Control;Biology;body cavity;Calcium Oscillations;Celiac Disease;cell behavior;Cell Count;Cell division;Cell Lineage;Cell Therapy;Cells;Compensation;Complex;Data;Daughter;Digestive Physiology;Disease;Drosophila genus;Endotoxemia;Enterocytes;Equation;Equilibrium;Experimental Models;Famines;fly;Food;frontier;Future;Genetic;genetic manipulation;Giardiasis;Goals;Growth;Health;Human;human disease;Image;in vivo;in vivo monitoring;Individual;Ingestion;innovation;Intestines;Invertebrates;Investigation;Knowledge;Label;Laboratories;Laboratory Study;Mammals;Mammary gland;mature animal;mechanical force;Mechanics;Methods;Midgut;Mitosis;Modeling;Modernization;Molecular;Monitor;Nutrient;optogenetics;Organ;Organ Size;Parenteral Nutrition;Pathologic;Pathway interactions;Periodicity;Physiological;promoter;Protocols documentation;purge;Refractory;Regulation;Reporter;Research;response;Rodent;serial imaging;Siblings;Side;Signal Transduction;Skeletal Muscle;Skin;Small Intestines;Starvation;stem cell differentiation;stem cell division;stem cells;Testing;Time;Tissues;tool;Transcription Coactivator;Translating;Undifferentiated;virtual;Wild Animals;Withdrawal;Work

PROJECT_TITLE: Mechanisms of Physiological Organ Shrinkage

STUDY_SECTION_NAME: Development - 1 Study Section[DEV1]


NIH_SPENDING_CATS: Biotechnology;Cancer;Gene Therapy;Genetics;Immunization;Immunotherapy;Lymphatic Research;Vaccine Related

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: PROJECT NARRATIVE CAR-T cell therapy has induced dramatic responses in hematological malignancies, representing one of the most remarkable therapeutic advances in the past decade, but efficacy in more common solid tumors has been limited by rapid dysfunction and poor persistence of tumor-infiltrating CAR-T cells. Successful tumor responses to immunotherapy are mediated by a subset of Tcf1+ T cells that resides in tumor-draining lymph nodes, where they retain the capacity to self-renew, proliferate, and continually differentiate into short-lived effector cells to sustain tumor killing. In this proposal, we will use a clinically relevant model of human lung cancer to investigate whether CAR-T cell activity is limited by inefficient formation of a Tcf1+ reservoir and whether this defect can be overcome using vaccination to expand lymph node reservoirs of Tcf1+ stem-like CAR-T cells, providing a strategy to enhance CAR-T cell efficacy that can be readily translated to the clinic to improve patient outcomes.

PI_NAMEs: SRIVASTAVA, SHIVANI  (contact)

PROGRAM_OFFICER_NAME: SINGH, ANJU

PROJECT_TERMS: Activities of Daily Living;Acute;Affinity;Antigen-Presenting Cells;Antigens;Cancer Patient;CAR T cell therapy;Carcinoma;Cells;chimeric antigen receptor T cells;Chronic;Chronic Lymphocytic Leukemia;Clinic;clinically relevant;comparison control;Data;Defect;design;draining lymph node;Effector Cell;effector T cell;Engineering;Environment;Epigenetic Process;exhaust;exhaustion;Flow Cytometry;FRAP1 gene;Functional disorder;Gene Modified;Head;Hematologic Neoplasms;Human;human model;Hypoxia;Immunotherapy;Impairment;improved;Infiltration;Infusion procedures;leukemia;lymph nodes;Maintenance;Malignant Breast Neoplasm;Malignant neoplasm of lung;Mediating;Memory;mesothelin;Microscopy;Modeling;mortality;mTOR inhibition;mTOR Inhibitor;Mus;neoplastic cell;novel;novel vaccines;Ovalbumin;overexpression;Patient-Focused Outcomes;Patients;PD-1 blockade;PD-L1 blockade;Peptide/MHC Complex;Peptides;phase I trial;Phenotype;preservation;programmed cell death protein 1;Proliferating;response;ROR1 gene;self-renewal;Signal Transduction;Sirolimus;Solid Neoplasm;stem;success;synergism;T-Cell Activation;T-Lymphocyte;Testing;Therapeutic;TP53 gene;transcriptome sequencing;Translating;tumor;Tumor Antigens;Tumor Expansion;tumor microenvironment;Tumor Promotion;Vaccination;vaccine platform;Work

PROJECT_TITLE: Improving CAR-T efficacy against solid tumors by expanding lymph node reservoirs of “stem-like” CAR-T cells

STUDY_SECTION: CIC

STUDY_SECTION_NAME: Cellular Immunotherapy of Cancer Study Section[CIC]


ADMINISTERING_IC: GM

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Nanotechnology

ORG_CITY: LINCOLN

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF NEBRASKA LINCOLN

ORG_STATE: NE

PHR: PROJECT NARRATIVE Nitric oxide is a small molecule that is required for cell signaling. Unfortunately, researchers know very little about the concentration and movement of nitric oxide because of a lack of easy-to-use, real-time sensors. This project will use a single walled carbon nanotube sensor to create sensing platforms that can detect nitric oxide in vitro and in vivo as well as utilizing the sensors to investigate nitric oxide’s role in cellular functions.

PI_NAMEs: IVERSON, NICOLE MARIE (contact)

PROGRAM_OFFICER_NAME: SALVADOR MORALES, CAROLINA

PROJECT_TERMS: biological systems;Cell Physiology;cell type;Cells;Communities;Development;Disease;Engineering;extracellular;Goals;improved;In Vitro;in vivo;Investigation;Laboratories;Learning;Measures;Membrane;Movement;Nitric Oxide;Organelles;Proteins;ratiometric;Reactive Oxygen Species;Research;Research Personnel;Role;sensor;Signal Transduction;Signaling Molecule;single walled carbon nanotube;small molecule;Specificity;System;Time;Work

PROJECT_TITLE: New and Improved Sensor Platforms and Quantification of Nitric Oxide for In Vitro and In Vivo Systems

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-N(55)R]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Hematology;Human Genome;Immunotherapy;Lymphatic Research;Lymphoma;Orphan Drug;Precision Medicine;Rare Diseases

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE These scientific studies assess important ways that Ibrutinib-based therapy for upfront therapy of CLL patients can be evaluated adding important decision parameters on who would benefit the most from this approach, strategies on how to best treat refractory or relapsed patients and on the most opportune times to utilize blood T cells for immunotherapy. In total this collective analysis will provide critical insights on this therapeutic approach and in this fashion improve the health of individuals with this disease.

PI_NAMEs: KAY, NEIL E (contact);SHANAFELT, TAIT D

PROGRAM_OFFICER_NAME: BHARTI, SANITA

PROJECT_TERMS: Agammaglobulinaemia tyrosine kinase;American;Architecture;Archives;arm;ATAC-seq;Automobile Driving;Biological Assay;Blood;Blood specimen;CAR T cell therapy;Cell Compartmentation;cell killing;Cell Physiology;Cell Separation;Cell Therapy;Cells;chimeric antigen receptor T cells;Chromatin;Chronic;Chronic Lymphocytic Leukemia;chronic lymphocytic leukemia cell;chronic T-cell leukemia;Clinical;Clinical Data;cohort;Combined Modality Therapy;comparative;Cyclophosphamide;Data;Decision Aid;Decision Making;design;Disease;Disease Progression;Disease remission;Drug resistance;Early treatment;Epigenetic Process;epigenomics;exhaust;fitness;fludarabine;follow-up;Fostering;Future;Gene Activation;Gene Expression;Generations;Genetic;Goals;Health;high dimensionality;Immune;Immune system;Immuno-Chemotherapy;Immunotherapeutic agent;Immunotherapy;improved;Individual;innovation;insight;International Prognostic Index;Knowledge;Learning;leukemia treatment;Leukemic Cell;Longitudinal Studies;Methylation;Modeling;Modernization;Molecular;molecular marker;multiple omics;Mutation;novel;novel therapeutics;Outcome;Outcome Study;Pathway interactions;patient population;patient subsets;Patient-Focused Outcomes;Patients;phase change;Phase III Clinical Trials;phase III trial;Phenotype;PLCG2 gene;predict clinical outcome;predictive tools;pressure;Prognostic Factor;prognostic model;prognostic tool;Progression-Free Survivals;Progressive Disease;Publishing;Recurrent disease;Refractory;Regulatory Pathway;Relapse;relapse patients;relapse prediction;Residual Neoplasm;Residual state;Resistance;response;restoration;Risk;risk prediction;rituximab;Sampling;Somatic Mutation;statistical and machine learning;T-Lymphocyte;targeted sequencing;targeted treatment;Techniques;Testing;Therapeutic;Time;Toxic effect;transcriptome sequencing;transcriptomics;Tumor Burden;Tyrosine Kinase Inhibitor;Validation;Work

PROJECT_TITLE: Outcomes for CLL patients treated with novel therapy

STUDY_SECTION: CBSS

STUDY_SECTION_NAME: Cancer Biomarkers Study Section[CBSS]


ORG_NAME: UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB

PHR: NARRATIVE, OVERALL DNA repair structures and mechanisms are an essential component to understanding and treating cancer. Defects in DNA repair pathways, such as mutagenic or genetic deficiencies can predispose cells to initiate cancer. DNA repair can also work antagonistically against cancer treatments that damage DNA, and in such cases, known mutations of DNA repair proteins in specific cancer cells provide opportunities to develop effective treatments. SBDR-5 brings together the top laboratories in DNA repair through multi-disciplinary collaborations to define the complex and dynamic network of DNA repair machines and to develop an actionable, quantitative and mechanistic knowledge of DNA repair machines, pathways and intersections with DNA replication and other DNA-related processes to aid prediction and intervention for cancer biology.

PI_NAMEs: TAINER, JOHN A. (contact)

PROGRAM_OFFICER_NAME: WITKIN, KEREN L

PROJECT_TERMS: Acceleration;Address;Alkylating Agents;arm;base;Biochemical;Biochemistry;Biological;biological adaptation to stress;Biological Markers;Biological Testing;Biology;Cancer Biology;cancer cell;Cancer Etiology;cancer genome;cancer initiation;Cancer Intervention;cancer therapy;causal variant;Cells;Cellular biology;Chemical Agents;Chemicals;chemotherapy;Clinical Trials;Complex;Data;Defect;Deposition;design;DNA;DNA biosynthesis;DNA Damage;DNA lesion;DNA Repair;DNA Repair Gene;DNA Repair Pathway;DNA replication fork;DNA Sequence Alteration;DNA Structure;Drug resistance;ds-DNA;effective therapy;Foundations;Genetic;genome database;Genome Stability;Goals;Individual;inhibitor;inhibitor therapy;insight;interdisciplinary approach;Interdisciplinary Study;Investments;knock-down;Knock-out;Knowledge;Laboratories;Lead;Lesion;Malignant Neoplasms;Mediating;Medical;Modeling;Molecular;Molecular Biology;Molecular Conformation;mutant;Mutation;Neoplastic Cell Transformation;Outcome;Pathway interactions;Patient risk;Patients;Phase;Phase Transition;Physical condensation;Poly(ADP-ribose) Polymerase Inhibitor;precision medicine;Precision therapeutics;preclinical trial;Predisposition;Preparation;prevent;Process;Prognosis;programs;Proteins;Publications;Radiation therapy;Repair Complex;repaired;Reproducibility;Research;Research Personnel;Resistance;Resistance development;response;RNA;Role;Shapes;Signal Transduction;Structural Biologist;structural biology;Structure;synergism;System;targeted agent;Technology;Testing;The Cancer Genome Atlas;Therapeutic;Therapeutic Intervention;therapy development;therapy resistant;treatment strategy;tumor;tumorigenesis;United States National Institutes of Health;Work

PROJECT_TITLE: Structural Cell Biology of DNA Repair Machines


NIH_SPENDING_CATS: Cancer;Genetics

PHR: NARRATIVE- PROJECT 1: Molecular response to base-modifying chemotherapeutic agents Many chemotherapeutics used for cancer damage bases in DNA and RNA. This project seeks to understand the mechanistic basis of a new repair complex involved in the processing of such base damage and how it relates to established pathways of base repair and chemotherapy responses.

PI_NAMEs: MOSAMMAPARAST, NIMA  (contact)

PROJECT_TERMS: adduct;Alkylating Agents;Alkylation;Apoptosis;Area;base;Base Excision Repairs;Binding;Biochemistry;Biological Assay;biophysical model;Biophysics;Cancer Biology;cancer therapy;Cell Line;Cell Survival;Cells;Cellular biology;chemotherapeutic agent;chemotherapy;Cisplatin;clinically relevant;clinically significant;Complex;coping;crosslink;Cryoelectron Microscopy;Crystallography;Defect;Disease;DNA;DNA Damage;DNA Repair;DNA Repair Pathway;Drug resistance;endonuclease;Endoribonucleases;Excision;Exposure to;genotoxicity;helicase;Individual;insight;Interferons;Knowledge;Lesion;Malignant Neoplasms;Measures;Mediating;Methods;Methylation;Modality;Modification;Molecular;molecular modeling;mutant;Neoadjuvant Therapy;neoplastic cell;nuclease;Nucleic Acids;Nucleotide Excision Repair;Pathway interactions;Pattern;Pharmacotherapy;Platinum Compounds;Positioning Attribute;Repair Complex;repaired;response;RNA;Roentgen Rays;Role;Signal Pathway;Signal Transduction;Single-Stranded DNA;structural biology;Structure;synergism;System;Testing;Therapeutic;Therapeutic Uses;therapy resistant;treatment response;tumor;Work

PROJECT_TITLE: Project 1: Base Repair: Molecular response to base-modifying chemotherapeutic agents


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: PORTLAND

ORG_NAME: PORTLAND VA MEDICAL CENTER

ORG_STATE: OR

PHR: An estimated 20% or more of Post-9/11 Veterans have had at least one military-related traumatic brain injury (TBI). Veterans with TBI are often co-diagnosed with neurological, mental health, and pain disorders that interfere with daily functioning. The VA’s Polytrauma/TBI System of Care (PSC) is an interdisciplinary program designed to meet the needs of Veterans with TBI and maximize their health and functioning using evidence-based practices. However, since the passage of the Veterans Choice and MISSION Acts, many Veterans with TBI are also receiving services from the VA’s network of Community Care providers. Dual use of services can lead to fragmented care, which may be particularly detrimental to Veterans with complex healthcare needs. This study will describe the use of Community Care (e.g., rates and types of; reliance on) among Post-9/11 Veterans with TBI; estimate associations between their Community Care reliance and health and functioning; and examine their experiences and satisfaction with Community Care.

PI_NAMEs: CARLSON, KATHLEEN F. (contact)

PROJECT_TERMS: Accountability;Address;Brain Concussion;care fragmentation;care providers;care systems;Caring;Case Management;Categories;Characteristics;Chronic;Classification;Clinical;Clinical Practice Guideline;Cognitive;combat veteran;Community Care Networks;Community Healthcare;comorbidity;Complex;daily functioning;Data;Databases;Dementia;Department of Defense;design;Development;Diagnosis;disability;Early Diagnosis;Education;Emotional;emotional symptom;Ensure;Evaluation;evidence base;Evidence based practice;Evidence based treatment;experience;Feeling suicidal;Functional disorder;functional outcomes;Guidelines;Health;Health Personnel;Health Services Accessibility;Healthcare;Healthcare Systems;improved;Injury;innovation;Integrated Health Care Systems;Interview;Knowledge;Link;Measures;Medical;Mental Depression;Mental Health;Methodology;Methods;mild traumatic brain injury;Military Personnel;military service;Modeling;mortality;Multiple Trauma;Neurobehavioral Manifestations;Neurologic;Outcome;Outsourcing;Pain;Pain Disorder;Patient Outcomes Assessments;patient population;Pattern;Perception;persistent symptom;Physical Medicine;Physical Rehabilitation;physical symptom;post 9/11;Post-Traumatic Stress Disorders;prevent;Process;programs;Provider;Quality of Care;Recommendation;Recording of previous events;Research;Research Methodology;research study;Resources;Risk;Sampling;satisfaction;screening;Services;Severities;sociodemographics;Source;Structure;Subgroup;Surveys;Symptoms;System;TBI Patients;Time;Traumatic Brain Injury;Trust;Veterans;Work

PROJECT_TITLE: Community Care Utilization among Post-9/11 Veterans with Traumatic Brain Injury

STUDY_SECTION_NAME: HSR-5 Health Care System Organization and Delivery and Women's Health[HSR5]


NIH_SPENDING_CATS: Cancer;Genetics;Radiation Oncology

PHR: NARRATIVE - Project 2: DSBR: Mechanisms of DNA double strand break repair and pathway selection Most cancer patients are treated with DNA double strand break inducing radiation and chemotherapy. Project 2 aims to understand how normal and cancer cells detect and repair DNA double strand breaks by integration of three major cellular pathways, non-homologous end joining, homology-directed repair and alternative end joining, leading to novel insights into mechanism and uncovering new approaches for therapeutic targeting.

PI_NAMEs: LEES-MILLER, SUSAN  (contact)

PROJECT_TERMS: artemis;BARD1 gene;Biochemical;biophysical techniques;BRCA1 gene;cancer cell;cancer genome;Cancer Model;Cancer Patient;cancer therapy;Cell Cycle;Cell Survival;Cells;Cellular biology;Chemicals;chemotherapy;Chemotherapy and/or radiation;Chromosomal Rearrangement;Clinic;Clinical Trials;Collaborations;Complex;Core Protein;Coupled;Cryoelectron Microscopy;cytotoxic;Development;DNA;DNA biosynthesis;DNA Double Strand Break;DNA Ligases;DNA Ligation;DNA Repair;DNA Repair Pathway;DNA replication fork;DNA-dependent protein kinase;DNA-Directed DNA Polymerase;DNA-PKcs;Double Strand Break Repair;Environment;Enzymes;Excision;G2 Phase;G22P1 gene;Genetic;Genomic Instability;Human;improved;In Vitro;inhibitor;Insecta;insight;Interphase;Interphase Cell;Invaded;Ionizing radiation;Joints;Knowledge;LIG4 gene;Ligation;Link;Malignant Neoplasms;Mediating;Molecular;Mutation;Non-Malignant;Nonhomologous DNA End Joining;Normal Cell;novel;novel strategies;novel therapeutic intervention;nuclease;Paint;Pathway interactions;patient response;Play;Poly(ADP-ribose) Polymerase Inhibitor;Polymerase;pre-clinical;precision medicine;preservation;presynaptic;Process;Productivity;protein expression;Proteins;Publications;Rad51 recombinase;Radiation induced double strand break;radiation response;Radiation therapy;Reagent;reconstruction;recruit;Regulation;repaired;Research Personnel;Resected;Resolution;Resort;response;Role;S phase;Single-Stranded DNA;Sister Chromatid;small molecule inhibitor;structural biology;Structure;student training;success;Synapses;synergism;Tail;Therapeutic;therapeutic target;tool;tumor;Tumor Suppressor Proteins;Work;XRCC1 gene;XRCC4 gene


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Brain Disorders;Fragile X Syndrome;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative Fragile X syndrome is the most common form of heritable intellectual disability and autism spectrum disorder. While this disease has been linked to instability and methylation of a short tandem repeat tract at a single gene, FMR1, we have shown that there are several other locations in the genome that are affected by pathologic Megabase-scale H3K9me3 deposition. Using cutting-edge genomics, mass spectrometry, and computational assays, we will investigate the RNA mechanisms driving heterochromatin-mediated gene silencing via inter-chromosomal interactions in fragile X syndrome.

PI_NAMEs: MALACHOWSKI, THOMAS ERNST (contact)

PROGRAM_OFFICER_NAME: MATTHEWS, MARGUERITE

PROJECT_TERMS: 5' Untranslated Regions;Affect;Aging;autism spectrum disorder;Automobile Driving;autosome;Back;Binding;Binding Proteins;Biological Assay;Cells;CGG repeat;Chromatin;chromatin modification;Cleavage Under Targets and Release Using Nuclease;clinical phenotype;Clustered Regularly Interspaced Short Palindromic Repeats;Data;Deposition;derepression;Disease;Distal;DNA;DNA Methylation;Engineering;Enzymes;epigenetic silencing;Excision;experimental study;FMR1 gene;Fragile X Syndrome;FXTAS;Gene Expression;Gene Silencing;Genes;Genetic Transcription;Genome;genome editing;genome-wide;Genomics;Heritability;Heterochromatin;Hi-C;histone modification;Human;human disease;Hybrids;Inclusion Bodies;induced pluripotent stem cell;Intellectual functioning disability;Knowledge;Length;Link;Literature;Location;Lysine;Malignant Neoplasms;Mass Spectrum Analysis;Mediating;Methylation;Modeling;Mutation;Nerve Degeneration;nerve stem cell;Nervous System Disorder;Normal Range;Nuclear;Nuclear Inclusion;Nuclear Pore Complex;Nucleotides;overexpression;Pathologic;pharmacologic;Phenotype;Plasmids;pluripotent stem cell differentiation;Printing;promoter;Proteins;Reader;recruit;Reporting;RNA;RNA Binding;RNA Sequences;RNA-Binding Proteins;Role;Seminal;Short Tandem Repeat;Structure;Synapses;Techniques;Testing;Transcript;Transcriptional Regulation;Transfection;Transgenes;Tremor/Ataxia Syndrome;Triplet Multiple Birth;Work;X Chromosome

PROJECT_TITLE: Elucidating the RNA-mediated mechanisms governing H3K9me3 deposition in fragile X syndrome

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F08-M(20)L]


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Racial and Ethnic Minority Health Research

ORG_CITY: SANTA CRUZ

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA SANTA CRUZ

PHR: Project Narrative Even young infants use race to categorize people, yet it is unclear how these perceptual tendencies translate to later social prejudice and stereotypes. The current project aims to examine the precursors of social biases across infancy to childhood by investigating infants’ cognitive inferences about racial groups and stranger fear toward people from different races. This work will elucidate the developmental trajectory of racial biases and how early social experience with racial diversity shapes infants’ emerging understanding of race.

PI_NAMEs: HWANG, HYESUNG GRACE (contact)

PROGRAM_OFFICER_NAME: ESPOSITO, LAYLA E

PROJECT_TERMS: 6 year old;7 year old;Age;age difference;Age Months;Attention;Award;Behavior;Behavioral;Categories;Censuses;Child;Childhood;Classification;Cognitive;Conceptions;Data;Data Set;demographics;Development;early childhood;Environment;expectation;experience;experimental study;Exposure to;Face;Face Processing;Friendships;Fright;Future;Human;improved;Individual;infancy;Infant;Infant Behavior;Knowledge;Language;Lead;Learning;longitudinal dataset;Mentors;Motivation;Nature;Neighborhoods;neural;neural correlate;neuromechanism;Persons;Phase;power analysis;preference;Prejudice;Process;Race;racial bias;racial diversity;racial population;racial prejudice;Randomized;Research;Research Personnel;Research Technics;response;Sampling;Shapes;skills;social;Social Behavior;social bias;social group;Social Interaction;Social Network;Speech;Stereotyping;Techniques;Testing;Time;Training;Translating;Work

PROJECT_TITLE: The malleability of social group understanding in infancy and early childhood

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


PHR: Project 3 - PARP: PAR-dependent, phase-transitioned protein assemblies and DNA repair PROJECT NARRATIVE Upon DNA damage, Poly-ADP-Ribose Polymerases (PARPs) generate polymers that seed the formation of phase condensates–highly concentrated yet fluid compartments of proteins at DNA damage sites. However, the functions of these specialized compartments in DNA repair is not understood. Understanding how PAR-seeded phase condensates regulate DNA repair pathways is critical because PARP inhibitors are increasingly used as cancer therapeutics. We propose to answer these fundamental questions by investigating the structural basis for the polymers, their effects on phase condensates, and the consequences for DNA repair in human cells. 1

PI_NAMEs: PAULL, TANYA T (contact)

PROJECT_TERMS: Adenosine Diphosphate Ribose;Affect;Alkylation;Biochemistry;Biophysics;Cells;Cellular biology;Characteristics;Clinic;Clinical;cofactor;Collaborations;Complex;defined contribution;Disease;DNA;DNA Damage;DNA Double Strand Break;DNA lesion;DNA Repair;DNA Repair Enzymes;DNA Repair Pathway;DNA replication fork;DNA-dependent protein kinase;Double Strand Break Repair;Drug Design;ds-DNA;Enzymes;Excision;EXO1 gene;fluorescence imaging;frontier;Gel;Generations;Glycoside Hydrolases;Histones;Human;Hydrolysis;in silico;In Vitro;in vitro Assay;inhibitor;insight;Length;Lesion;Liquid substance;Malignant Neoplasms;Measures;Methods;Modeling;Modification;Monitor;mutant;Outcome;Pattern;Phase;Phase Transition;Physical condensation;Poly Adenosine Diphosphate Ribose;poly ADP-ribose glycohydrolase;poly ADPR glycohydrolase inhib;Poly(ADP-ribose) Polymerase Inhibitor;Poly(ADP-ribose) Polymerases;polymerization;Polymers;polypeptide;Post-Translational Protein Processing;Production;Proteins;recruit;Regulation;Repair Complex;repaired;replication stress;Research;Resolution;response;Role;single molecule;Site;small molecule;stress tolerance;Structural Biochemistry;structural biology;Structure;success;Tertiary Protein Structure;Testing;Therapeutic;therapeutic target;therapy outcome;tool;Work

PROJECT_TITLE: Project 3: PARP: PAR-dependent, phase-transitioned protein assemblies and DNA repair


NIH_SPENDING_CATS: Genetics;Infectious Diseases

ORG_CITY: STONY BROOK

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

PHR: 8. PROJECT NARRATIVE  The fungal cell wall is the interface between the cell and its environment. In pathogenic fungi, proper function of the cell wall is important for survival in the host, and drugs targeting cell wall assembly are effective antifungal agents. The spores of baker's yeast Saccharomyces cerevisiae are not pathogenic but are surrounded by a complex coat, the spore wall, which includes many of the same components found in the walls of pathogenic fungi. We are using spore wall formation as a model system to unravel the biochemistry and genetics of fungal wall assembly. This application focuses on understanding how a conserved set of proteins localized on lipid droplets promote the formation of a specific structural feature in the cell wall.

PI_NAMEs: NEIMAN, AARON M (contact)

PROGRAM_OFFICER_NAME: RIGAS, MARC

PROJECT_TERMS: Acyltransferase;anti-fungal agents;Appearance;beta-Glucans;Biochemistry;Bioinformatics;Biological Models;Candida;Candida albicans;Cell Physiology;cell type;Cell Wall;Cells;Chitosan;Complex;Cryptococcus neoformans;D Cells;Dimethylallyltranstransferase;dityrosine;drug resistant pathogen;Drug Targeting;effective therapy;Encapsulated;Environment;environmental stressor;Enzymes;Evolution;fungal genetics;Gene Deletion;Gene Family;Genes;Genetic;Genome;glucan synthase;Goals;Grant;Haploidy;Immunocompromised Host;In Vitro;in vitro activity;in vitro Assay;Individual;Infection;inhibitor;insight;Label;lipidomics;Lipids;Mannans;Measures;Meiosis;Molecular;Morphogenesis;mutant;Mycoses;Organelles;particle;pathogen;pathogenic fungus;Pathogenicity;Pathway interactions;Phenotype;polyphenol;Polysaccharides;Population;Process;Protein Family;protein function;Proteins;Public Health;Regulation;Reproduction spores;Resistance;resistant strain;Role;Saccharomyces cerevisiae;Saccharomycetales;Set protein;side effect;solid state nuclear magnetic resonance;Stress;Testing;Triglycerides;Yeasts

PROJECT_TITLE: Assembly and Function of the Yeast Spore Wall

STUDY_SECTION_NAME: Cell Structure and Function 1 Study Section[CSF1]


NIH_SPENDING_CATS: Genetics;Neurodegenerative

ORG_CITY: AMES

ORG_DEPT: CHEMISTRY

ORG_NAME: IOWA STATE UNIVERSITY

ORG_STATE: IA

PHR: PROJECT NARRATIVE The proposed research will reveal general mechanistic principles of protein-RNA liquid-liquid phase separation, the misregulation of which is known to be a signiﬁcant source of neurodegenerative diseases. Our study will indicate novel preventative strategies guided by simulations and theory, which could be used to control the protein- RNA condensates and combat processes that lead to protein aggregation linked with mental disorders.

PI_NAMEs: POTOYAN, DAVIT  (contact)

PROGRAM_OFFICER_NAME: NGUYEN, HAN

PROJECT_TERMS: Biochemical Reaction;Biological;Biopolymers;Cell Nucleus;Characteristics;combat;Complex;computerized tools;Cytoplasm;Cytoplasmic Granules;Data;Diffusion;Disease;driving force;Elements;Eukaryota;experimental study;flexibility;gene regulatory network;Genes;Genetic Transcription;Grain;Heterogeneity;In Vitro;in vivo;insight;Intervention;Intracellular Membranes;Investigation;Link;link protein;Liquid substance;Mental disorders;Molecular;Molecular Conformation;molecular dynamics;molecular modeling;Nature;Neurodegenerative Disorders;novel;Nucleic Acids;Organelles;Phase;Phenotype;Physical condensation;Prevention strategy;Process;programs;protein aggregation;protein TDP-43;Proteins;Reaction;Research;Resolution;RNA;RNA-Binding Protein FUS;Role;simulation;Source;spatiotemporal;stem;stress granule;Structure;System;tau Proteins;Techniques;theories;Thermodynamics;Training

PROJECT_TITLE: Multi-scale computational investigation of functions and mechanisms of protein-RNA phase separation.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-K(55)R]


NIH_SPENDING_CATS: Autoimmune Disease;Diabetes

ORG_CITY: SAINT LOUIS

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Recent studies suggest that in addition to insufficient insulin, abnormal glucagon secretion from pancreatic β-cells may also play a central role in the cause and complications of diabetes. Despite significant progress in our understanding of this important hormone, the cellular and molecular mechanisms that regulate glucagon secretion from β-cells remain largely unknown. Elucidation of these mechanisms will provide new therapeutic targets for the regulation of glucagon secretion that can be used for novel treatment strategies in both Type 1 and Type 2 diabetes.

PI_NAMEs: PISTON, DAVID W (contact)

PROGRAM_OFFICER_NAME: HWA, ALBERT J

PROJECT_TERMS: Alpha Cell;Animals;antagonist;Beta Cell;Biochemical;Biological Assay;Biosensor;blood glucose regulation;Cell Physiology;Cell surface;cell type;Cells;Clinical;Closure by clamp;Complex;Complications of Diabetes Mellitus;Cyclic AMP;Cyclic AMP-Dependent Protein Kinases;D Cells;Data;data integration;Deterioration;Diabetes Mellitus;diabetic patient;Dominant-Negative Mutation;Electrophysiology (science);euglycemia;Exhibits;Exocytosis;experimental study;F-Actin;Genetic;Glucagon;Glucagon Receptor;Glucose;Hormone secretion;Hormones;Human;hyperglucagonemia;Hyperglycemia;Hypoglycemia;Image;improved;in vivo;Individual;innovation;Insulin;insulin secretion;insulin signaling;Insulin-Dependent Diabetes Mellitus;Ion Channel;islet;Islet Cell;Islets of Langerhans;Ligands;Link;Measurement;Measures;Mediating;Methods;Microfluidics;Modeling;Molecular;mouse model;Mus;new therapeutic target;novel;pancreatic juice;paracrine;Paracrine Communication;Pathology;Pathway interactions;Pattern;Persons;Phosphorylation;Play;polymerization;Polymers;Protein Dephosphorylation;Proteins;Regulation;Research;response;rho GTP-Binding Proteins;RNA Interference;Role;side effect;Signal Pathway;Signal Transduction;small molecule;SNAP receptor;Somatostatin;Structure of alpha Cell of islet;Structure of beta Cell of islet;Testing;therapeutic target;Transgenic Mice;treatment strategy;type I and type II diabetes;Work

PROJECT_TITLE: Regulation of Glucagon Secretion from Pancreatic Islets


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

PHR: Project Narrative This competitive renewal application will continue to train highly skilled scientist scholars from diverse backgrounds who will have a future impact on health care equity, quality, and accessibility for diverse communities. IRACDA NY-CAPS Scholars will benefit from a comprehensive research and teacher training program that will make them competitive in the academic job market; and as faculty, they will be in the best position to generate new scopes of research and transmit cutting-edge developments to a future generation of diverse students in the biomedical sciences. Ultimately, the NY-CAPS program will help to generate a new and diverse workforce of highly talented Americans that are fully engaged in issues of public health and this will bring special attention to issues of health disparities in underserved communities.

PI_NAMEs: CARTER, CAROL A (contact);WRIGHT, KARIAN JANICE

PROGRAM_OFFICER_NAME: BLATCH, SYDELLA ANNE

PROJECT_TERMS: Address;Award;Biomedical Research;biomedical scientist;career;career development;Cities;Collaborations;college;Communication;community college;County;curriculum development;Development;Educational process of instructing;Educational workshop;Environment;ethnic diversity;experience;Exposure to;Faculty;Feedback;Fostering;Funding;higher education;innovation;Institution;Mentors;Modeling;Monitor;New York;pedagogy;Phase;Population;Positioning Attribute;Postdoctoral Fellow;Productivity;programs;Race;Research;resilience;Scholars Program;Science;Scientist;Series;skills training;teacher;tenure track;Training;undergraduate student;Universities

PROJECT_TITLE: IRACDA at Stony Brook University

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - C[TWD-C]


PHR: NARRATIVE - PROJECT 4: Fork Repair: Mechanisms and consequences of stalled replication fork processing The vast majority of mutations, including those that drive cancer, are generated during DNA replication. This project will discover the mechanisms that ATP-dependent motor proteins use to avoid error and complete DNA synthesis.

PI_NAMEs: CORTEZ, DAVID K (contact)

PROJECT_TERMS: Binding;Biochemical;Biochemistry;Biological;biological adaptation to stress;Biophysics;Cancer Etiology;cancer therapy;Cell Physiology;Cells;Cellular biology;chemotherapeutic agent;Collaborations;Coupled;Cryoelectron Microscopy;Dangerousness;Development;Digestion;DNA;DNA biosynthesis;DNA Damage;DNA Repair;DNA replication fork;DNA Structure;DNA-Binding Proteins;driver mutation;Drug resistance;endonuclease;Ensure;Enzymes;Exonuclease;Genetic;genetic approach;Genome Stability;Genomic Instability;Genomics;interest;Malignant Neoplasms;Manuscripts;Mass Spectrum Analysis;Methodology;Motor;Mutation;novel therapeutics;Pathway interactions;Poly(ADP-ribose) Polymerase Inhibitor;Post-Translational Protein Processing;Predisposition;Process;Proteins;Proteome;Reagent;Recording of previous events;Regulation;repaired;replication stress;Research;Research Personnel;response;shunt pathway;SMARCA3 gene;Stress;stress tolerance;structural biology;Structure;targeted treatment;Testing;Therapeutic Intervention;translocase;tumor;tumorigenesis;ubiquitin ligase;Work;X-Ray Crystallography

PROJECT_TITLE: Project 4: Fork Repair: Mechanisms and consequences of stalled replication fork processing


NIH_SPENDING_CATS: Bioengineering;Breast Cancer;Cancer;Data Science;Networking and Information Technology R&D (NITRD);Precision Medicine;Prevention;Women's Health Research

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

PHR: Project Narrative Toward precision medicine and precision disease prevention, the overarching goal of this proposal is to develop innovative statistical methods for accurate risk prediction. We address three challenges that plague studies on the value of new predictors that adds to standard predictors for improving predictive accuracy: lack of independent validation data, lack of statistical methods for developing risk prediction models using individually-matched case-control data, and lack of statistical methods to guide study design beyond standard power calculation for testing predictor-outcome association. We will develop innovative statistical methods to address these challenges. Our methods, accompanied by user-friendly software, are expected to facilitate cost effective and timely biomarker evaluation for predicting binary outcomes.

PI_NAMEs: CHEN, JINBO  (contact)

PROGRAM_OFFICER_NAME: CHEN, HUANN-SHENG

PROJECT_TERMS: Address;Adopted;Agreement;Big Data;Biological Markers;biomarker evaluation;Breast Cancer Risk Factor;breast density;Calibration;case control;Clinical Research;Communities;cost effective;Data;Data Set;design;disorder prevention;Ensure;epidemiology study;Estrogens;Evaluation;Feasibility Studies;flexibility;Gestational Diabetes;Goals;Hormonal;improved;Individual;innovation;Logistic Regressions;Logistics;Malignant Neoplasms;Measures;metabolomics;Methods;model building;Modeling;novel;Outcome;outcome prediction;Patients;Population;precision medicine;predictive modeling;Publications;Research Design;Risk;Risk Marker;risk prediction;risk prediction model;Sampling;Sampling Studies;Source;Statistical Methods;Target Populations;Testing;user friendly software;Validation

PROJECT_TITLE: Data and Information Integration for Risk Prediction in the Era of Big Data

STUDY_SECTION: BMRD

STUDY_SECTION_NAME: Biostatistical Methods and Research Design Study Section[BMRD]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cardiovascular;Congenital Heart Disease;Congenital Structural Anomalies;Genetics;Heart Disease;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: SAN FRANCISCO

ORG_NAME: J. DAVID GLADSTONE INSTITUTES

PHR: PROJECT NARRATIVE Congenital heart defects are present in 1-2 out of 100 births, and are caused by mutations in genes that may control the 3-dimensional organization of chromosomes. We will use human cellular models and Artificial Intelligence to understand how chromosome organization is controlled during heart development and altered by disease processes. This will reveal fundamental concepts of gene regulation and may lead to a better understanding congenital heart defects towards improving diagnosis and treatment.

PI_NAMEs: BRUNEAU, BENOIT GAETAN (contact);POLLARD, KATHERINE S.

PROGRAM_OFFICER_NAME: POSTOW, LISA

PROJECT_TERMS: 3-Dimensional;Adult;Architecture;Arrhythmia;Artificial Intelligence;ATAC-seq;Birth;Cardiac;Cardiac Myocytes;cardiogenesis;Cardiovascular Diseases;CCCTC-binding factor;Cell Differentiation process;Cell Line;Cell model;cell type;Cells;Child;ChIP-seq;Chromatin;Chromatin Remodeling Factor;Chromosome Structures;Code;cohesin;Complex;computational platform;Congenital Abnormality;congenital heart abnormality;Congenital Heart Defects;Data;Data Set;deep learning model;Development;Diagnosis;directed differentiation;Disease;disease-causing mutation;Elements;Endothelial Cells;Engineering;Enhancers;Family;Frequencies;GATA4 gene;Gene Expression;Gene Expression Regulation;gene regulatory network;Genes;Genetic;Genetic Determinism;Genetic Transcription;Genome;Genome Mappings;Genomics;Heart;Heart Diseases;high throughput screening;histone modification;Histones;Human;Human Biology;Human Development;human disease;human induced pluripotent stem cells;human model;improved;in silico;Machine Learning;machine learning method;Maps;Measures;Modeling;Molecular;Mutate;Mutation;novel;Patients;Phenotype;pluripotent stem cell differentiation;predictive modeling;Process;promoter;Proteins;Regulation;Regulatory Element;Resolution;SMARCA2 gene;stem cell model;Structure;Time;transcription factor;Untranslated RNA;Variant;Work

PROJECT_TITLE: Genetic determinants of 4D genome folding in human cardiac development

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-S(70)R]


NIH_SPENDING_CATS: Cancer

PHR: NARRATIVE - CORE 3: Administrative Core (ADM) The overall goal of this Program Project on “Structural Cell Biology of DNA Repair Machines” (SBDR) is to develop detailed structural and mechanistic understanding of the multi-protein machines that carry out DNA repair processes in human cells. These results will advance cancer intervention through the identification of specific ways to control biological outcomes of cellular responses to DNA damage and to exploit specific cancer cell vulnerabilities. This effort involves experimental cycles between structural and functional studies in four Projects with 18 senior investigators. The ADM Core enables this multi-institutional effort by providing overall management of SBDR, facilitating communications, and fostering Program integration.

PI_NAMEs: TSUTAKAWA, SUSAN EMIKO (contact)

PROJECT_TERMS: Administrator;Advanced Malignant Neoplasm;anti-cancer research;Biological;Budgets;Cancer Biology;cancer cell;Cancer Intervention;Cells;Cellular biology;Collaborations;Communication;Communities;design;DNA Damage;DNA Repair;Educational workshop;Ensure;Environment;Equity;experience;Fostering;Genome;Goals;Hearing;Human;Individual;Infrastructure;Institution;Laboratories;Letters;Maintenance;meetings;member;Monitor;operation;Outcome;Phase Transition;Postdoctoral Fellow;Preparation;Process;Productivity;programs;Progress Reports;Proteins;Publications;Recommendation;Recording of previous events;Reporting;Research;Research Personnel;Resource Sharing;response;Scientific Advances and Accomplishments;Scientist;Senior Scientist;Social Distance;Specialist;structural biology;Structure;success;synergism;United States National Institutes of Health;videoconference;virtual;webinar;Work;Writing

PROJECT_TITLE: Core 3: Administrative Core


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Precision Medicine

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: Narrative: The MSK Genomic Data Analysis Center for Tumor Evolution will create a software platform for analysis of DNA mutations in cancer to help researchers and clinicians better understand why cancers often relapse. As cancer is a disease that changes at the cellular level over time, with some cells killed by treatment while others survive, we need to understand which mutations lead to treatment failure in specific patients. We expect that with improved tools that can measure, monitor and interpret changes in disease over time, we will make advances that allow for better management of cancer and prevention of relapse.

PI_NAMEs: SCHULTZ, NIKOLAUS  (contact);SHAH, SOHRAB P

PROGRAM_OFFICER_NAME: YANG, LIMING

PROJECT_TERMS: Aftercare;Alleles;analytical method;Anatomy;Area;Biological Assay;Biological Process;Biopsy;cancer cell;Cancer Center;cancer genome;cancer genomics;cancer type;cBioPortal;Cell Communication;cell free DNA;cell killing;cell type;Cells;Clinical;clinical development;clinical sequencing;ClinVar;Clonal Evolution;Clonal Expansion;Computer software;Copy Number Polymorphism;Data;Data Analyses;Data Sources;data visualization;Diagnosis;Disease;Disease Progression;DNA;DNA Mutational Analysis;DNA Sequence Alteration;DNA sequencing;driver mutation;Engineering;Epigenetic Process;Evolution;exome;fitness;Gene Cluster;Gene Expression Profile;Genes;genetic variant;genome analysis;Genome Data Analysis Center;genome sequencing;Genomics;Growth;Heterogeneity;Human Characteristics;Immune;improved;Individual;Infrastructure;innovation;interactive visualization;Investigation;Laboratories;Lead;lens;Literature;longitudinal analysis;Machine Learning;Malignant neoplasm of ovary;Malignant Neoplasms;Maps;Measures;Methods;Modeling;Modification;Molecular;Monitor;multimodality;Mutation;Neoplasm Metastasis;neoplastic cell;new therapeutic target;novel;Oncogenic;Pathogenesis;Pathway interactions;Patient Monitoring;patient population;Patients;Pharmacotherapy;Phenotype;Phylogenetic Analysis;Ploidies;Population;Positioning Attribute;precision oncology;Prevalence;Primary Neoplasm;Process;programs;Recurrence;Relapse;relapse prevention;Research Personnel;Resistance;resistance mutation;Resolution;RNA;Sample Size;Sampling;Scientist;Series;Signal Pathway;single cell analysis;single-cell RNA sequencing;Site;software infrastructure;Somatic Mutation;Specificity;Statistical Methods;Statistical Models;Surveys;targeted treatment;The Cancer Genome Atlas;Therapeutic Intervention;therapy development;therapy resistant;Time;time use;tool;transcriptome;transcriptome sequencing;Treatment Failure;treatment response;Trees;tumor;tumor growth;tumor heterogeneity;tumor progression;Variant;Visualization;whole genome;Work


NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics

ORG_CITY: BERKELEY

PHR: NARRATIVE - CORE 1: EXPRESSION AND MOLECULAR BIOLOGY (EMB) CORE High quality protein samples remain rate-limiting for gaining quantitative, high-resolution structural information for DNA repair machinery functions. The EMB Core provides centralized resources and expertise in advanced recombinant protein expression technologies to reduce this major hurdle for individual labs. The EMB Core will accelerate SBDR research by synergizing with all four Projects and the SCB Core to enable mechanistic insights into challenging DNA repair proteins and complexes.

PI_NAMEs: TSAI, MIAW-SHEUE  (contact)

PROJECT_TERMS: Acceleration;Architecture;Bacteria;Baculoviruses;Biochemical;Biological;Biophysics;Cancer Biology;Catalogs;Cells;Cellular biology;Clinical;Cloning;Cloning Vectors;Collaborations;Collection;combinatorial;Communication;Complement;Complex;Coupled;Data;design;DNA;DNA Repair;DNA Repair Gene;empowerment;Engineering;Escherichia coli;expression vector;flexibility;Funding;Gene Expression;Genes;Goals;Human;human DNA;Individual;Information Dissemination;Insecta;insight;Investigation;Ligation;Malignant Neoplasms;member;Methodology;Methods;Modernization;Molecular;Molecular Biology;Molecular Cloning;Multiprotein Complexes;Mutation;nanobodies;operation;precision medicine;Procedures;Production;Productivity;programs;protein complex;protein expression;protein protein interaction;protein purification;Proteins;Protocols documentation;rational design;Reagent;Recombinant Proteins;Recording of previous events;Repair Complex;repository;Research;Research Support;Resolution;Resources;Sampling;Scale Insects;scale up;screening;searchable database;Secure;Services;Site-Directed Mutagenesis;Standardization;stoichiometry;synergism;System;Technical Expertise;Techniques;Technology;Testing;Training;Validation;vector;web site

PROJECT_TITLE: Core 1: Expression and Molecular Biology (EMB)


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Congenital Structural Anomalies;Contraception/Reproduction;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Nutrition;Patient Safety;Pediatric;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: CHICAGO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Narrative Women of reproductive age with type 2 diabetes are at greater risk for a number of negative health and reproductive outcomes. We developed the Promoting REproductive Planning And REadiness in Diabetes (PREPARED) strategy to [1] promote medication safety, [2] prompt provider preconception counseling, and [3] deliver patient-friendly educational tools and post-visit text messages to support diabetes self-care. We will test the effectiveness of PREPARED, against usual care, to improve patient knowledge of reproductive risks and recommended self-care activities, engagement in diabetes self-management behaviors, and glycemic control.

PI_NAMEs: BAILEY, STACY C (contact)

PROGRAM_OFFICER_NAME: LAWRENCE, JEAN M

PROJECT_TERMS: Adherence;Adult;Adult women;Adverse event;Affect;Age;aged;arm;Behavior;Behavior Control;behavioral outcome;Blood Pressure;cardiovascular risk factor;Cardiovascular system;Chicago;Clinic Visits;Clinical;Conceptions;Congenital Abnormality;congenital anomaly;Contraceptive methods;Counseling;Data;design;Diabetes Mellitus;diabetes self-management;Diet;Disease;disparity reduction;Drug Prescriptions;early onset;Education;Effectiveness;effectiveness evaluation;effectiveness testing;Electronic Health Record;Enrollment;Ensure;ethnic disparity;ethnic minority;Folic Acid;Friends;glycemic control;Glycosylated hemoglobin A;Goals;Guidelines;Health;health disparity;health literacy;Health system;healthy lifestyle;high risk;implementation intervention;improved;Incidence;indexing;Intervention;Interview;Knowledge;LDL Cholesterol Lipoproteins;Link;literacy;low health literacy;male;Measures;medication safety;Methods;Morbidity - disease rate;mortality;Neighborhood Health Center;Neural Tube Defects;Non-Insulin-Dependent Diabetes Mellitus;Not Hispanic or Latino;Older Population;Outcome;Patient Education;Patients;Perinatal mortality demographics;Persons;Pharmaceutical Preparations;Pharmacy facility;Physical activity;Population;Preconception Care;Pregnancy;Premature Birth;prevent;Primary Care;primary care practice;Printing;Provider;Public Health;racial disparity;racial minority;randomized trial;Readiness;Recommendation;reproductive;reproductive outcome;Resources;Review Literature;Risk;Risk Factors;Safety;Self Care;Site;Spanish/English;Spontaneous abortion;Technology;Teratogens;Testing;Text Messaging;Time;tool;treatment as usual;unintended pregnancy;Visit;White Women;Woman;Work;young adult

PROJECT_TITLE: Promoting Preconception Care and Diabetes Self-Management among Reproductive-Aged Women with Diabetes: The PREPARED Trial

STUDY_SECTION: CMGC

STUDY_SECTION_NAME: Clinical Management in General Care Settings Study Section[CMGC]


PHR: NARRATIVE, CORE 2: STRUCTURAL CELL BIOLOGY (SCB) Quantitative structural information can provide highly informative clues to how proteins work and in cases of patient mutations, clues as to how they fail. The SCB Core provides empowering access to and expertise on cutting-edge structural biology technologies needed to probe DNA repair proteins and complexes and not available in individual research institutions.

PI_NAMEs: HURA, GREGORY L (contact)

PROJECT_TERMS: Acceleration;Active Sites;Address;Architecture;beamline;Binding;Biology;Buffers;Cells;Cellular biology;Communication;Complement;Complex;Coupled;crosslink;Cryoelectron Microscopy;Crystallization;Crystallography;Data Analyses;Data Collection;design;DNA;DNA Probes;DNA Repair;DNA Repair Gene;DNA Repair Pathway;DNA-dependent protein kinase;empowerment;Environment;Eukaryotic Cell;Exclusion;flexibility;Fluorescence;genome integrity;Goals;Gold;imaging modality;Individual;Institution;Label;Laboratories;Ligands;Light;Malignant Neoplasms;Mass Spectrum Analysis;Measurement;Measures;member;Methods;Microscopy;Modality;Modeling;Molecular;Molecular Conformation;Mutation;New York;Nuclear;Optics;Patients;Phase Transition;photonics;Process;programs;protein purification;Proteins;Publications;reconstitution;Repair Complex;Research;Research Personnel;Resolution;Resources;response;RNA;Roentgen Rays;Scientist;screening;sensor;Signal Transduction;single-molecule FRET;small molecule;Source;structural biology;Structure;superresolution microscopy;Synchrotrons;System;Technology;Testing;ultra high resolution;Variant;Visit;Visualization;Work;X-Ray Crystallography;X-Ray Tomography

PROJECT_TITLE: Core 2: Structural Cell Biology (SCB) Core


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Clinical Research;Eye Disease and Disorders of Vision;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: INDIANAPOLIS

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: PROJECT NARRATIVE The project is relevant to public health because studying how Wnt signaling affects glucocorticoid-induced changes in the trabecular meshwork is ultimately expected to increase our understanding of the pathogenesis of glucocorticoid-induced glaucoma and provide therapeutic targets to the development of safer glucocorticoids. Therefore, the proposed research is relevant to the part of NEI’s mission that pertains to developing fundamental knowledge with respect to blinding eye diseases.

PI_NAMEs: MAO, WEIMING  (contact)

PROGRAM_OFFICER_NAME: SONG, HONGMAN

PROJECT_TERMS: Affect;Antiinflammatory Effect;Aqueous Humor;arm;ATAC-seq;autoimmune uveitis;beta catenin;Binding;Biological Assay;Cattle;Cells;Chromatin;Complex;conditional knockout;Data;Development;Dexamethasone;Disease;DNA;drug development;Endotoxins;Enhancers;Enzymes;Epigenetic Process;Eye;Eye diseases;Fluorescence Resonance Energy Transfer;Future;Gene Expression;General Population;Genes;Glaucoma;Glucocorticoid Receptor;Glucocorticoids;Goals;HDAC1 gene;High-Throughput Nucleotide Sequencing;histone modification;Homeostasis;Human;Inflammatory;inhibitor;Knock-out;Knockout Mice;Knowledge;Lead;Methyl-CpG-Binding Protein 2;Mission;Modeling;Modification;Molecular;Mus;novel strategies;Nuclear;Ocular Hypertension;Pathogenesis;Pathway interactions;Patients;Pattern;Perfusion;Physiologic Intraocular Pressure;prevent;Primary Open Angle Glaucoma;Public Health;Publications;Publishing;Receptor Signaling;recruit;Regulation;Reporter;Research;responders and non-responders;response;Response Elements;Role;side effect;Signal Induction;Signal Transduction;small hairpin RNA;small molecule;success;Testing;Therapeutic Effect;Therapeutic Glucocorticoid;therapeutic target;Tissues;Trabecular meshwork structure;transcriptome sequencing;Transgenic Organisms;Transposase;Uveitis;WNT Signaling Pathway

PROJECT_TITLE: The role of Wnt signaling in treating glucocorticoid-induced glaucoma

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]


ORG_CITY: DURHAM

ORG_DEPT: BIOLOGY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE The proposed research is relevant to public health given the paramount importance of nutrient-responsive pathways to health and disease. Dysregulation of such pathways causes cancer and diabetes, but their fundamental role in starvation is not well understood. Deeper understanding of the regulatory network that mediates adaptation to starvation will suggest preventive strategies and therapeutic interventions to reduce public health burden.

PI_NAMEs: BAUGH, LARRY RYAN (contact)

PROJECT_TERMS: Acute;Affect;Aging;Biochemical;Biological Assay;Caenorhabditis elegans;Cancer Etiology;Chromatin Structure;Clinical;Complex;Data;deep sequencing;Development;Diabetes Mellitus;Disease;Famines;Food;Foundations;Functional disorder;Gene Expression;Gene Expression Regulation;Gene Family;gene repression;Genes;Genetic;Genetic Epistasis;Genomics;Goals;Growth;hatching;Health;high dimensionality;Histone H1;Histones;Human;human disease;innovation;Insulin;Insulin Receptor;Investigation;Larva;Literature;Lobular Neoplasia;Longevity;Malignant Neoplasms;MAP Kinase Gene;Measures;Mediating;member;Metabolism;Modeling;Modification;Molecular;mortality;novel;Nutrient;Nutritional;Orthologous Gene;Outcome;Pathway interactions;PIK3CG gene;Population;Prevention strategy;protein function;Protein phosphatase;Proteins;Proto-Oncogenes;PTEN gene;Public Health;Publishing;Regulation;Repression;Reproduction;Research;Resistance;resistance mechanism;Role;Signal Transduction;Starvation;System;Testing;Therapeutic Intervention;trait;transcription factor;Transcriptional Regulation;tumor;Tumor Suppressor Proteins;Variant;Work;ZFY protein

PROJECT_TITLE: Genetic and Genomic Analysis of Starvation Resistance in C. elegans

STUDY_SECTION: CMAD

STUDY_SECTION_NAME: Cellular Mechanisms in Aging and Development Study Section[CMAD]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Dietary Supplements;Kidney Disease;Nutrition;Physical Activity;Prevention

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Project Narrative Frailty is common in patients with advanced kidney disease and contributes to increased mortality in this population. Exercise, an intervention that is used to prevent the adverse outcome of frailty, is not as effective in patients with kidney failure. This study will assess how to improve the efficiency of exercise in patients with kidney failure by combining mitochondrial-targeted therapy with exercise.

PI_NAMEs: GAMBOA, JORGE LUIS;IKIZLER, TALAT ALP (contact)

PROGRAM_OFFICER_NAME: PARSA, AFSHIN

PROJECT_TERMS: adverse outcome;Affect;Anaerobic Threshold;Biogenesis;Biopsy;Body Weight decreased;Chronic Kidney Failure;Clinical;Clinical Trials;Coenzyme Q10;Coenzyme Q10 deficiency;COVID-19 pandemic;Data;DNA copy number;Double-Blind Method;Electron Transport;End stage renal failure;Energy Metabolism Pathway;Enrollment;Equilibrium;Exercise;exercise capacity;exercise intolerance;exercise program;exercise training;exhaustion;Fatigue;Fiber;frailty;General Population;Generations;Genetic Transcription;Health;Hemodialysis;Home;Impairment;improved;in vivo;Individual;Infrastructure;Interval training;Intervention;intervention effect;Investigation;Kidney Diseases;Kidney Failure;lifestyle intervention;Magnetic Resonance Spectroscopy;Maintenance;Measures;Metabolic;Mitochondria;Mitochondrial DNA;mitochondrial dysfunction;Morbidity - disease rate;mortality;Muscle;Muscle Contraction;Muscle Fibers;muscle form;Muscle function;Muscle Mitochondria;muscle strength;Muscle Weakness;Muscular Atrophy;novel;Oxygen Consumption;participant enrollment;Patient Self-Report;patient subsets;Patients;Permeability;Persons;Phenotype;Physical activity;Physical Exercise;Physical Function;Physical Performance;Physiological;placebo controlled trial;Placebos;Population;PPAR gamma;preservation;prevent;primary outcome;Proteins;Quality of life;Randomized;randomized, clinical trials;reduced muscle mass;Renal Replacement Therapy;Reporting;Research Design;resistance exercise;Respiration;respiratory;responders and non-responders;response;Risk;Role;sarcopenia;secondary outcome;Skeletal Muscle;standard of care;stressor;Supplementation;System;targeted treatment;Testing;therapeutic target;Time;tool;Training;Training Programs;transcriptome sequencing;transcriptomic profiling;Ubiquinone;Uncontrolled Study;Variant;Vulnerable Populations;Walking;walking speed

PROJECT_TITLE: Role of Mitochondrial Dysfunction in the Response to Exercise in Patients with Advanced Kidney Disease

STUDY_SECTION: SMEP

STUDY_SECTION_NAME: Skeletal Muscle and Exercise Physiology Study Section[SMEP]


NIH_SPENDING_CATS: Clinical Research;Digestive Diseases;Food Allergies;Nutrition

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative Allergic reactions to peanuts and tree nuts are a major health problem for which current treatments are inadequate. This project will establish a new intellectual framework regarding allergen/IgE interactions, describe, at least in part, the molecular basis for co-allergies among tree nuts and peanuts, design new diagnostics and move us along the path toward development of an oral, peptide based, treatment for peanut allergy.

PI_NAMEs: DRESKIN, STEPHEN C (contact)

PROGRAM_OFFICER_NAME: SUBRAMANIAN, HARIHARAN

PROJECT_TERMS: 3-Dimensional;Adult;Affect;Affinity;Albumins;Allergens;Allergic Reaction;Allergy to peanuts;Amino Acids;analog;anti-IgE;Area;Basophils;Binding;Biological Assay;Biotin;Cashew nut;Cells;Chemistry;Child;Clinical;Clinical Research;Clinical Trials;clinically relevant;cost;Cross Reactions;cross reactivity;Data;design;Development;Diagnostic;Enzyme-Linked Immunosorbent Assay;Epitopes;Europe;Food;Food Hypersensitivity;Health;Hypersensitivity;IgE;IgG4;Immunologics;Immunotherapy;improved;Individual;Juglans;mast cell;Measures;Mediating;Microarray Analysis;Modeling;Molecular;Molecular Conformation;novel;novel diagnostics;novel strategies;Nut Hypersensitivity;Nuts;omalizumab;Oral;oral immunotherapy;oral tolerance;Outcome;Patients;Pattern;Pecans;Peptide Hydrolases;Peptides;Pistachio Nuts;Predictive Value;Reagent;Resistance;Sampling;screening;Side;Streptavidin;success;Surface Plasmon Resonance;Technology;Testing;Therapeutic;three dimensional structure;Trees;United States;Vertebral column

PROJECT_TITLE: Exploiting and enhancing IgE-binding epitopes of the 2S albumins of peanuts and tree nuts

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIB-E(57)]


NIH_SPENDING_CATS: Biotechnology;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: DAVIS

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: This project will train researchers to discover and develop new treatments for disorders of the brain and nervous system so as to reduce disability and lead to improved quality of life.

PI_NAMEs: ROGAWSKI, MICHAEL A. (contact);SLUSHER, BARBARA STAUCH

PROGRAM_OFFICER_NAME: O'NEIL-MATHURIN, OREISA NICOLE

PROJECT_TERMS: Academia;Address;ADME Study;Advocacy;American;animal efficacy;Antibodies;apprenticeship;Area;base;Binding;Biological;Biological Assay;biological development;Biological Products;Biological Response Modifier Therapy;Brain;Brain Diseases;Breathing;career;commercialization;Communities;community building;Continuing Education;Critiques;design;Development;Development Plans;disability;drug development;drug discovery;Educational Curriculum;efficacy testing;Elements;Event;experience;Faculty;Formulation;Funding;Future;Gene Transduction Agent;Goals;Government;improved;Individual;Industry;instructor;Intellectual Property;interest;Knowledge;Lead;Learning;lecturer;lectures;Legal patent;meetings;member;Mentors;Monoclonal Antibodies;Nervous System;Nervous System Disorder;Oligonucleotides;Participant;Pharmaceutical Chemistry;Postdoctoral Fellow;Process;Quality of life;Research;Research Personnel;responsible research conduct;Rotation;safety testing;Scientist;Series;skills;small molecule;Societies;Special Event;Specialist;student participation;Students;success;teacher;Teacher Professional Development;Toxicology;Training;Training Programs;Viral Vector;Vision;Work

PROJECT_TITLE: Training in Neurotherapeutics for Academic Scientists

STUDY_SECTION: NSD

STUDY_SECTION_NAME: Neurological Sciences and Disorders B Study Section[NSD-B]


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Diabetes;Digestive Diseases;Hepatitis;Liver Disease;Nutrition;Obesity

ORG_CITY: SAN DIEGO

ORG_NAME: EPIGEN BIOSCIENCES, INC.

PHR: Narrative The objective is to develop new drugs for treating diseases that lead to liver fibrosis, including non- alcoholic steatohepatitis (NASH), a significant cause of mortality.

PI_NAMEs: KOHLI, ROHIT ;TUCCI, FABIO COHEN (contact)

PROGRAM_OFFICER_NAME: DENSMORE, CHRISTINE L

PROJECT_TERMS: Acute;Affect;Agonist;Animal Model;Animals;antagonist;Anti-Inflammatory Agents;Authorization documentation;Biological Assay;C57BL/6 Mouse;candidate selection;Carbohydrates;Cardiovascular Physiology;Cardiovascular system;CCL2 gene;Cell Proliferation;Cells;Chronic;Chronic Disease;Cicatrix;Cirrhosis;Clinic;Clinical Data;clinical efficacy;Clinical Pathways;Clinical Trials;commercialization;Data;Deposition;Diabetic Nephropathy;Diabetic Neuropathies;Diet;Disease;Dose;Drug Combinations;Dyslipidemias;effective therapy;efficacy study;epigen;Fatty acid glycerol esters;Feedback;feeding;Female;Fibrosis;Fructose;Goals;Grant;Hepatic Insufficiency;Hepatic Stellate Cell;Histologic;Human;human disease;improved;In Vitro;in vivo;Individual;Infiltration;Inflammation;Insulin Resistance;Investigational New Drug Application;Investments;Lead;Life Style;Liver;liver biopsy;Liver diseases;Liver Fibrosis;Lysophosphatidic Acid Receptors;Macrophage;male;Malignant neoplasm of liver;meetings;Metabolic syndrome;migration;Modeling;Monkeys;mortality;mouse model;Mus;non-alcoholic fatty liver disease;Non-Insulin-Dependent Diabetes Mellitus;nonalcoholic steatohepatitis;novel therapeutics;Obesity;Outcome;patch clamp;Pathology;Pathway interactions;Patients;Pharmaceutical Preparations;Pharmacology Study;Phase;Phase I Clinical Trials;phase III trial;Population;Pre-Clinical Model;preclinical efficacy;preclinical evaluation;preclinical safety;Preparation;Prevalence;Privatization;Process;programs;Rattus;Regimen;Research;Respiratory System;response;Risk;Safety;safety assessment;safety study;Small Business Innovation Research Grant;standard measure;Supplementation;telemetering;Therapeutic;United States Food and Drug Administration;Wild Type Mouse;Work

PROJECT_TITLE: Candidate selection of a LPAR1 antagonist for therapeutic application in NASH


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: Project Narrative Our experimental studies are designed to delve deeply into the role of aging on the regulation cholesterol metabolism, inflammation, and lung injury. Metagenomic sequencing will provide us with additional insights into the specific tissues of origin and the degree of cellular injury.

PI_NAMEs: STOUT DELGADO, HEATHER WINONA (contact)

PROGRAM_OFFICER_NAME: TILAHUN, MULUALEM ENYEW

PROJECT_TERMS: 25-hydroxycholesterol;Acute Respiratory Distress Syndrome;Adhesions;Adopted;Adoptive Transfer;Adult;age effect;age related;age related changes;aged;Aging;aging process;Agreement;Alveolar;Alveolar Macrophages;Anti-Inflammatory Agents;Biological Assay;cell injury;Cell Physiology;cell type;Cells;Cessation of life;Cholesterol;Cholesterol Homeostasis;Clinical;Communicable Diseases;cytokine;Data;Defect;design;Development;ds-DNA;endoplasmic reticulum stress;Environment;Enzymes;Epithelial Cells;experimental study;Feedback;Growth Factor;healing;Homeostasis;Host Defense;Human;Immune;Immune response;Immune signaling;Immunologics;Infection;Inflammation;Inflammatory;injured;Injury;Innate Immune Response;innovation;insight;Link;lipid metabolism;Liquid substance;Lung;lung injury;Macrophage;Macrophage Activation;Mediating;Metabolic;Metabolism;metagenomic sequencing;Metagenomics;Microbe;Mitochondria;Mixed Function Oxygenases;Modeling;Molecular;Mus;novel;overexpression;oxidation;Patients;Phagocytosis;Phenotype;Plasma;Play;Pneumococcal Infections;Process;Production;Publishing;Pulmonary Pathology;recruit;Regulation;Resolution;Respiratory System;response;response to injury;Role;Severities;Severity of illness;Signal Transduction;Streptococcus pneumoniae;Structure of parenchyma of lung;surfactant;Techniques;Testing;tissue injury;Tissues;tool;transcriptomics;Work

PROJECT_TITLE: Impact of Aging on Oxysterol Regulation of Alveolar Macrophage Function during S. pneumoniae


ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: Project Narrative Vitamin A is essential for the development of adaptive immunity in the intestine. This project will define the biochemical, cell biological, and microbiological mechanisms that regulate vitamin A delivery to the intestinal immune system, and will determine how these mechanisms affect the development of adaptive immunity. The findings from the proposed project could reveal new strategies for pharmacologic and dietary manipulation of intestinal immunity.

PI_NAMEs: HOOPER, LORA V (contact)

PROGRAM_OFFICER_NAME: SENGER, STEFANIA

PROJECT_TERMS: absorption;adaptive immune response;Adaptive Immune System;adaptive immunity;Affect;All-Trans-Retinol;B-Cell Development;B-Lymphocytes;Bacteria;Bacterial Infections;Binding;Biochemical;Biological;Cell surface;Cells;Complex;Cryoelectron Microscopy;Development;Diet;dietary;dietary manipulation;Disease;Epithelial Cells;Epithelium;gastrointestinal epithelium;Goals;gut microbiota;Homing;Human;Immune;immune function;Immune response;Immune system;Immunity;Immunoglobulin A;Immunologics;Individual;Infection;Inflammation;insight;Intestinal Absorption;Intestinal Diseases;intestinal epithelium;Intestinal Secretions;Intestines;Knowledge;Lamina Propria;LDL-Receptor Related Protein 1;Lipids;Lipoprotein (a);Lipoproteins;Low-Density Lipoproteins;microbial;microbiota;microorganism;Molecular;Molecular Chaperones;Myeloid Cells;Natural Immunity;Oral;pathogenic bacteria;Pathogenicity;Pathway interactions;pharmacologic;Play;Production;Proteins;receptor;Receptor Cell;recruit;Regulation;Retinol Binding Proteins;Role;Serum amyloid A protein;Small Intestines;Structure;Study of serum;T-Lymphocyte;Testing;Tretinoin;uptake;Vaccination;Vitamin A

PROJECT_TITLE: Microbial Regulation of Retinol Transport and its Role in Intestinal Immunity

STUDY_SECTION: DHMI

STUDY_SECTION_NAME: Digestive System Host Defense, Microbial Interactions and Immune and Inflammatory Disease Study Section[DHMI]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: NARRATIVE For 25 years, the RCMAR Center for Aging in Diverse Communities (CADC) at the University of California San Francisco has been successfully delivering a robust mentoring and training program and providing a culture of equity and inclusion for early career researchers from diverse backgrounds who will enhance the aging-research workforce. In this renewal, CADC’s multidisciplinary faculty have the experience and expertise to train and mentor this next generation of researchers focused on aging-related health disparities. Through impactful research, CADC Faculty and Scientists will contribute to improving the health status for older adults in diverse populations and achieving health equity.

PI_NAMEs: KARLINER, LEAH S (contact)

PROGRAM_OFFICER_NAME: RICE, ELISE

PROJECT_TERMS: Aging;aging related;Area;Behavioral;Behavioral Mechanisms;Behavioral Research;California;career;career development;Collaborations;Communities;community organizations;cultural equity;education research;Environment;equity, diversity, and inclusion;Exclusion;experience;Faculty;faculty community;Fostering;Funding;Goals;Growth;Health Disparities Research;health disparity;health equity;health inequalities;Health Status;Hispanic-serving Institution;human capital;improved;Infrastructure;Institution;Intervention;Joints;Leadership;Mentors;Mentorship;Methodology;Methods;Minority;multidisciplinary;next generation;older adult;organizational structure;Outcome;outcome disparities;Pilot Projects;Population;Population Heterogeneity;Positioning Attribute;Process;programs;Publications;Research;Research Methodology;Research Personnel;Resources;San Francisco;Scientist;social;Strategic Planning;Structure;tool;Training;Training and Education;Training Programs;Underrepresented Populations;United States National Institutes of Health;Universities;web site

PROJECT_TITLE: Center for Aging in Diverse Communities: Ending Health Inequities in Older Adults


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

PROJECT_TERMS: Address;Advisory Committees;Aging;aging related;Area;Award;Behavioral;Behavioral Mechanisms;Behavioral Sciences;Biomedical Research;California;career;career development;Clinical Investigator;Clinical Trials;cognitive neuroscience;Collaborations;Communities;community advisory board;Community Care Networks;community engaged research;cultural equity;Dedications;education research;Ensure;Environment;Epidemiology;Equity;equity, diversity, and inclusion;Ethnic Population;Exclusion;experience;Faculty;faculty community;Focus Groups;Fostering;Funding;gender minority group;Geography;Health Disparities Research;health disparity;health equity;health inequalities;Health Services Research;Healthcare;Hispanic-serving Institution;implementation science;Institution;Intervention;Joints;Lead;Leadership;Measurement;meetings;Mentors;Mentorship;Methodology;Methods;Minority;multidisciplinary;next generation;older adult;outcome disparities;Pilot Projects;Population;Population Sciences;Practice based research;Process;programs;racial population;recruit;Reporting;Research;Research Personnel;Resources;Rural;San Francisco;Scientist;sexual minority group;social;Social Sciences;Structure;System;Talents;Training;Training Programs;Underrepresented Populations;United States National Institutes of Health;Universities

PROJECT_TITLE: Leadership and Administrative Core


NIH_SPENDING_CATS: Aging;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: NEILANDS, TORSTEN BRIAN (contact)

PROJECT_TERMS: Acceleration;Aging;aging related;Behavior Therapy;Behavioral Mechanisms;burden of illness;career;Collaborations;Communities;community research;Complex;Consultations;Data Analyses;Data Set;data sharing;Data Sources;design;Diagnosis;Disparity;diverse data;education research;Educational Curriculum;Equity;Face;Funding;Goals;Health;health determinants;Health Disparities Research;health disparity;health equity;health equity promotion;Health equity research;health inequalities;Health Services Accessibility;improved;Intervention;Leadership;Life Cycle Stages;Measurement;Mentors;Methodology;Methods;older adult;outcome disparities;Pilot Projects;Policies;Population;Population Group;Population Heterogeneity;programs;Publications;Quality of life;Recording of previous events;Reduce health disparities;Research;Research Design;Research Methodology;Research Personnel;Resources;Scientist;social;Statistical Data Interpretation;tool;Training;treatment response;United States National Institutes of Health;web site;Work

PROJECT_TITLE: Analysis Core


NIH_SPENDING_CATS: Aging;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: PALMER, NYNIKKA  (contact)

PROJECT_TERMS: Advisory Committees;African American;Aging;aging related;Asian;Asian Americans;Behavioral Mechanisms;Black race;California;career;career development;Collaborations;Communities;community research;Cultural Backgrounds;Data;Department chair;Education;education research;Equity;ethnic diversity;ethnic health disparity;Ethnic Population;evidence base;experience;Faculty;faculty community;faculty mentor;Feedback;Funding;Goals;Grant;Health;Health Disparities Research;health disparity;health equity;health inequalities;Healthcare;Hispanic;improved;innovation;Intervention;Latino;Leadership;Medical;Medicine;meetings;mentoring community;Mentors;Mentorship;Methods;National Institute on Aging;Nursing Faculty;older adult;Older Population;outcome disparities;peer;Physicians;Population;Principal Investigator;process improvement;programs;Publishing;Race;racial health disparity;racial population;Recommendation;Reporting;Research;Research Personnel;Research Project Grants;Resources;Role;San Francisco;Scientist;Secure;senior faculty;skills;social;success;Time;Training;Training and Education;United States Dept. of Health and Human Services;United States National Institutes of Health;Universities

PROJECT_TITLE: Research Education Component


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Macular Degeneration;Neurodegenerative;Neurosciences

ORG_CITY: AUGUSTA

ORG_NAME: AUGUSTA UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE This proposal seeks to develop a new molecular strategy to limit subretinal fibrosis in blinding eye disease. PFKFB3 (6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase isoform 3) is a critical regulator/activator of glycolysis. The proposed studies are designed to use Pfkfb3 deficient mice and PFKFB3 knockdown/overexpressing RPE cells to investigate the involvement of glycolysis in RPE cells in subretinal fibrosis and to define the underlying mechanisms.

PI_NAMEs: YANG, QIUHUA  (contact)

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: 6-Phosphofructo-2-kinase;6-Phosphofructokinase;Actins;Anatomy;Area;cell type;Cells;Choroid;Choroidal Neovascularization;Cicatrix;Complex;Data;design;Development;Endothelial Cells;Endothelium;Enzyme Activation;Enzymes;epithelial to mesenchymal transition;Exudative age-related macular degeneration;Eye diseases;Fibrosis;Fructose;Fructose-2,6-bisphosphatase;Genetic;Glycolysis;HIF1A gene;Hypoxia;In Vitro;in vitro Model;in vivo;Inflammatory;knock-down;Knock-out;Laser injury;Lasers;Lesion;Macrophage;Mediating;Mentors;Mesenchymal;Metabolic;Metabolic Pathway;Metabolism;migration;Modeling;Molecular;Mus;Myeloid Cells;Myofibroblast;Neuroglia;novel strategies;overexpression;Oxygen;Pathway interactions;Patients;Phosphotransferases;Production;Profibrotic signal;Protein Isoforms;Pyruvate;Retina;retinal angiogenesis;Retinal Diseases;Rodent Model;Role;Smooth Muscle;Structure of retinal pigment epithelium;Testing;Therapeutic;tool;Transforming Growth Factor beta;treatment strategy;Vision;Visual impairment;VLDL receptor;Work

PROJECT_TITLE: RPE PFKFB3 in subretinal fibrosis


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Networking and Information Technology R&D (NITRD)

ORG_CITY: EVANSTON

ORG_NAME: PROTEINACEOUS, INC.

PHR: PROJECT NARRATIVE The proposed software product will be the first commercial top-down mass spectrometry acquisition platform dedicated to characterizing intact proteins. By automating protein characterization for academia and industry workflows, the new software will yield proteoform insights that can ultimately help advance biomedical research and shorten therapeutic development time.

PI_NAMEs: DURBIN, KENNETH  (contact)

PROGRAM_OFFICER_NAME: BARNES, CHARLES ASHLEY

PROJECT_TERMS: Academia;Algorithms;analytical tool;Antibodies;Automation;Biological Process;Biological Products;Biomedical Research;Computer software;computerized data processing;Consumption;cost;dashboard;Data;data acquisition;Data Aggregation;Data Analyses;Data Collection;data quality;Dedications;design;Development;Disease;Ensure;equipment acquisition;experience;experimental study;feature detection;flexibility;Generations;improved;Industry;insight;instrument;interest;Intervention;Laboratories;Machine Learning;Mass Spectrum Analysis;Measurement;Methods;Modeling;Modification;Molecular;Output;Pharmaceutical Preparations;Phase;Post-Translational Protein Processing;prevent;Process;Productivity;Proteins;Regression Analysis;Reporting;Running;Sampling;Scheme;Specificity;Speed;System;Technology;Therapeutic;therapeutic development;therapeutic protein;Time;timeline;tool;Update;Visual;Visualization;Voice

PROJECT_TITLE: Data-Driven Software to Automate Top-Down Mass Spectrometry of Large Molecules