ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Neurosciences;Nutrition;Obesity

ORG_NAME: NEW YORK UNIVERSITY

PHR: Project Narrative The development of strategies to prevent or treat obesity is among the top priorities for healthcare and research communities. Adipose thermogenesis plays a crucial role in enhancing whole-body energy expenditure and improving systemic metabolism. The proposed work aims to elucidate the mechanisms responsible for controlling the activation and expansion of thermogenic adipose tissue.

PI_NAMEs: SHAMSI, FARNAZ  (contact)

PROGRAM_OFFICER_NAME: GUPTA, DHANANJAY

PROJECT_TERMS: Address;Adipocytes;adipokines;Adipose tissue;Adult;Affect;angiogenesis;Anti-diabetic Drugs;axon guidance;Biological;Blood Vessels;Body Temperature;Brown Fat;C-terminal;Cardiometabolic Disease;cardiometabolism;cell type;Cells;Chemicals;chemoproteomics;Chronic;combat;Communication;Communities;Coupled;Data;density;Development;diet-induced obesity;Endothelial Cells;Energy Metabolism;Engineering;Environment;Exhibits;experimental study;gain of function;Genetic Transcription;glucose metabolism;Health;Health Priorities;Healthcare;House mice;Human;improved;in vivo;innovation;interest;knock-down;Laboratories;Length;Ligands;lipid biosynthesis;lipid metabolism;Lipids;loss of function;Mediating;Metabolic;Metabolism;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;mutant;N-terminal;Nerve;nerve supply;Neurites;Neurons;neurovascular;Obesity;obesity treatment;obesogenic;Organism;Outcome;overexpression;Pathway interactions;Peptide Hydrolases;Physiologic Thermoregulation;Play;preservation;prevent;Prevention strategy;Process;procollagen C-endopeptidase;progenitor;Property;Proteolytic Processing;Reagent;receptor;receptor binding;Regulation;Research;response;Risk Factors;Rodent;Role;Series;Signal Transduction;single-cell RNA sequencing;Site;Temperature;Testing;Thermogenesis;Tissues;transcriptomics;treatment strategy;Work

PROJECT_TITLE: Mechanisms of slits3 signaling in thermogenic adipose tissue

STUDY_SECTION: POMD

STUDY_SECTION_NAME: Pathophysiology of Obesity and Metabolic Disease Study Section[POMD]


ADMINISTERING_IC: GM

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Immunotherapy;Infectious Diseases;Neurodegenerative;Neurosciences

ORG_CITY: SAN JUAN

ORG_COUNTRY: UNITED STATES

ORG_DEPT: SURGERY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF PUERTO RICO MED SCIENCES

ORG_STATE: PR

PHR: Project narrative Our immune system has evolved to combat diseases via diverse and multifaceted mechanisms; however, certain immune cells can become self-destructive and promote disease conditions such as autoimmune, cancer, cardiovascular, inflammatory, and central nervous system disorders. The proposed purchase of a flow cytometer will allow a comprehensive analysis of immune and diseased cell populations, extracellular vesicles, and cell surface and intracellular proteins to identify functional and dysfunctional cell characteristics and forward our understanding of the role of the immune system in human disease as well as advance research capabilities in Puerto Rico.

PI_NAMEs: DHARMAWARDHANE, SURANGANIE  (contact)

PROGRAM_OFFICER_NAME: BECKETT, DOROTHY

PROJECT_TERMS: academic program;Address;Alzheimer's Disease;Applications Grants;Autoimmune;Biomedical Research;Blood;Cancer Patient;career development;cell type;Cells;Colitis;Communicable Diseases;Complex;Computer software;Core Facility;Data;Dedications;Development;Disease;Education;Educational process of instructing;Equipment;experience;Faculty;Flow Cytometry;Funding;graduate student;Grant;Health;health disparity;Hispanic;Human;Immune;Immune System Diseases;Immunologist;Immunotherapy;Individual;Infection;Inflammatory;Institution;instrument;Laboratories;Lasers;Lead;Leadership;Maintenance;Malignant Neoplasms;Medical;Medical Students;Mus;Nerve Degeneration;Neurodegenerative Disorders;particle;Play;Population;Publications;Puerto Rican;Puerto Rico;Research;Research Personnel;Research Project Grants;Resources;response;Role;Science;student training;Students;Suspensions;Technology;Therapeutic;Tissues;tool;Training;tumor microenvironment;undergraduate student;underrepresented minority student;United States National Institutes of Health;Universities

PROJECT_TITLE: Flow cytometer for analysis of immune and other cell types

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CDB-L (30)]


ADMINISTERING_IC: DA

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Drug Abuse (NIDA only);Neurosciences;Substance Misuse

ORG_CITY: BOSTON

ORG_DEPT: BIOLOGY

ORG_NAME: HARVARD MEDICAL SCHOOL

ORG_STATE: MA

PHR: Narrative Dopamine is important for normal brain function, and defects in dopamine transmission are associated with many brain disorders. We will dissect mechanisms through which dopamine controls movement, reward processing and reinforcement learning. Our results will likely revise central models in the field on dopamine function, and generate new understanding on actions of drugs of abuse in the brain.

PI_NAMEs: KAESER, PASCAL SIMON (contact);UCHIDA, NAOSHIGE

PROGRAM_OFFICER_NAME: BERTON, OLIVIER

PROJECT_TERMS: Ablation;Action Potentials;Acute;Area;Axon;Behavior;Behavior Control;Behavioral;Behavioral Assay;Biology;Brain;Brain Diseases;calcium indicator;Clinical;cocaine self-administration;Corpus striatum structure;Data;Defect;Disease;Dopamine;dopaminergic neuron;Dorsal;drug action;Drug Addiction;drug of abuse;genetic approach;Goals;Impairment;in vivo;insight;Kinetics;Knowledge;Laboratories;Learning;Measures;Mediating;Midbrain structure;Modeling;Molecular and Cellular Biology;Motivation;Motor;motor skill learning;mouse genetics;Movement;Mus;mutant;Mutant Strains Mice;neural;Neuromodulator;Neurons;novel strategies;Output;Parkinson Disease;Patients;Pattern;permissiveness;Pharmaceutical Preparations;Phase;presynaptic;Proteins;Psychological reinforcement;Receptor Activation;Regulation;Research;reward processing;Rewards;Role;sensor;Signal Transduction;Testing;tool;transmission process;Ventral Striatum;Work

PROJECT_TITLE: Roles for dopamine signaling modes in striatal circuit modulation and behavior

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Lewy Body Dementia;Neurodegenerative;Neurosciences;Parkinson's Disease;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: PHILADELPHIA

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: RO1 (Renewal Application) Narrative Understanding biomarkers of cognitive decline in Lewy body diseases Lewy body disease (LBD) patients differ widely in the extent and the time course with which their underlying alpha-synuclein (aSyn) pathology affects cognition, with dementia with Lewy bodies (DLB) individuals affected cognitively at onset, while Parkinson’s disease (PD) individuals develop cognitive decline at least one year, or, in some cases, many decades, later. This RO1 renewal application will investigate the contribution of host characteristics – reflected by biomarker signatures – to cognitive heterogeneity in the LBD. We will also investigate the contribution of “proteinopathy” characteristics – reflected by species of aSyn detected by two conformation-selective antibodies – to cognitive heterogeneity.

PI_NAMEs: CHEN-PLOTKIN, ALICE S (contact)

PROGRAM_OFFICER_NAME: BABCOCK, DEBRA J

PROJECT_TERMS: Affect;Age;aging population;alpha synuclein;Alzheimer's disease related dementia;Antibodies;Apolipoprotein A-I;Apolipoproteins;Behavior;beta amyloid pathology;Biochemical;Biological;Biological Assay;Biological Markers;Biological Models;biomarker signature;Brain;Cardiovascular Diseases;Cells;Characteristics;Clinical;clinical diagnosis;clinical phenotype;Clinical Trials;Cognition;Cognitive;cognitive impairment in Parkinson's;cohort;cost;Data;demented;Dementia;Dementia with Lewy Bodies;Deposition;Development;Diagnosis;Digestion;Disease;disease model;Disease Progression;Endopeptidase K;Epitopes;Exhibits;experimental study;Family;follow-up;Funding;Genetic Predisposition to Disease;genetic variant;Genetic Variation;Goals;Hallucinations;Healthcare Systems;Heterogeneity;Human;Immunoprecipitation;Impaired cognition;in vivo;in vivo Model;Individual;induced pluripotent stem cell;Induced pluripotent stem cell derived neurons;insight;Knock-out;Lead;Lewy Body Disease;Life;Ligation;Literature;Maps;Mass Spectrum Analysis;Measures;Melanoma;Mendelian randomization;Methods;Microglia;mimetics;Modeling;Molecular;Molecular Conformation;Monoclonal Antibodies;motor symptom;mouse model;Neurobehavioral Manifestations;Neurons;neuropathology;Outcome;Parkinson Disease;Parkinson's Dementia;Pathogenesis;Pathology;Patients;Pharmaceutical Preparations;phenomenological models;Phenotype;Plasma;Plasma Proteins;Play;pre-clinical;Process;programs;Proteins;Quality of life;Reporting;Reproducibility;Role;Sampling;screening;Senile Plaques;Severity of illness;Site;synucleinopathy;System;targeted treatment;Testing;therapeutic development;Therapeutically Targetable;Time;uptake;Work

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: GAINESVILLE

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE Our visual experience depends on the ability of retinal photoreceptor cells to transmit responses based on light excitation to downstream neurons in the visual circuitry. Perturbations in synaptic communication between the photoreceptors and their downstream partners will lead to a variety of blinding diseases. Here we propose experiments that will uncover the molecular mechanisms allowing photoreceptors to organize their synaptic contacts with downstream retinal neurons, which we expect will provide insights into strategies to treat blinding diseases.

PI_NAMEs: MARTEMYANOV, KIRILL A. (contact);SAMPATH, ALAPAKKAM P

PROGRAM_OFFICER_NAME: WRIGHT, CHARLES BAKER

PROJECT_TERMS: Ablation;Adaptor Signaling Protein;adhesion receptor;Adhesions;Affect;Anatomy;Area;Attention;Behavioral;Biochemical;Biological;Biology;Blindness;Brain;Calcium Channel;Cell Adhesion Molecules;cell type;Cells;Communication;comorbidity;Complex;conditional knockout;Cone;Data;Dendrites;Disease;Electrophysiology (science);experience;experimental study;Feedback;G-Protein-Coupled Receptors;Glutamates;Goals;horizontal cell;Human;insight;Lateral;Light;light intensity;light transmission;Measures;Mediating;Molecular;mouse model;Mus;Nature;Neurons;neurotransmitter release;Neurotransmitters;Output;Photophobia;Photoreceptors;Physiological;Play;postsynaptic;presynaptic;Presynaptic Terminals;Productivity;Property;protein function;Protein Isoforms;Proteins;receptor;Regulation;response;Retina;Retinal Cone;retinal neuron;Retinal Photoreceptors;Role;scaffold;selective expression;Shapes;Signal Transduction;Site;Specificity;Synapses;Synaptic Receptors;Synaptic Transmission;System;Testing;transmission process;TRPM1 gene;Vertebrate Photoreceptors;Vision;Visual;visual processing;Work

PROJECT_TITLE: Molecular Basis of Photoreceptor Wiring

STUDY_SECTION: BDE

STUDY_SECTION_NAME: Biology and Development of the Eye Study Section[BDE]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Autism;Brain Disorders;Fragile X Syndrome;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Rare Diseases

ORG_CITY: Nashville

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: We propose glia have core brain circuit remodeling roles in experience-dependent critical periods, a process impaired in heritable intellectual and autism spectrum disorders. We discovered multiple interacting genes involved in glial infiltration, engulfment and phagocytosis, which we propose are required for this early-life mechanism, with causal roles in several interlinked genetic models of these disorders. This research program tests glial functions and neuron-to-glia signaling in experience-dependent critical period remodeling.

PI_NAMEs: BROADIE, KENDAL  (contact)

PROGRAM_OFFICER_NAME: LEE, CRYSTAL ANNE

PROJECT_TERMS: Adolescent;Adult;Afferent Neurons;Animals;autism spectrum disorder;Automobile Driving;Biological Assay;Biosensor;Brain;brain circuitry;Brain Mapping;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;critical period;Cues;Cyclic AMP-Dependent Protein Kinases;Dependence;Disease;disease model;Dose;Drosophila genus;experience;FMR1 gene;Fragile X Syndrome;gene environment interaction;gene interaction;Genetic;genetic manipulation;Genetic Models;glial activation;Heritability;Human;Image;Impairment;in vivo;Individual;Infiltration;Intellectual functioning disability;knock-down;Knock-out;Label;Learning;LEOPARD Syndrome;Life;light microscopy;Link;MAP Kinase Gene;Maps;Mediating;Memory;Messenger RNA;Modeling;Molecular;Multiple Lentigines;mutant;Mutate;Mutation;neural circuit;Neuroglia;neuronal circuitry;Neurons;Neuropil;neurotransmission;Noonan Syndrome;Odorant Receptors;optogenetics;Output;Pathway interactions;Phagocytes;Phagocytosis;Phase;Phosphoric Monoester Hydrolases;Phosphotransferases;Positioning Attribute;Process;programs;protein expression;Proteins;PTPN11 gene;recruit;Regulation;Regulatory Pathway;Reporter;Research;Resolution;Role;Sensory;sensory input;Signal Pathway;Signal Transduction;Synapses;synaptic pruning;System;Testing;time use;tool;Transgenic Organisms;Translations;Transmission Electron Microscopy;Visualization;Work

PROJECT_TITLE: Glial roles in experience-dependent critical period remodeling

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Diabetes;Genetics;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

PHR: PROJECT NARRATIVE In spite of extensive approaches, critical limb ischemia (CLI) is still one of the leading causes of disability and mortality in diabetic patients in USA. In this proposal, we will investigate whether enhanced muscle-specific miR- 499, which has been considered as a marker of ischemic tissue injury in human, and its downstream signaling targets can modulate endothelial/endothelial progenitor cell-mediated ischemic limb repair in diabetes. The results of this proposal will therefore be highly relevant for improving public health and improving the length and quality of life of millions of diabetic patients.

PI_NAMEs: KISHORE, RAJ  (contact)

PROGRAM_OFFICER_NAME: GALIS, ZORINA S

PROJECT_TERMS: Affect;Anabolism;angiogenesis;Angiogenesis Inhibition;Angiogenic Factor;Animals;Autologous;Biological Markers;Biology;Blood capillaries;blood perfusion;Bone Marrow Cells;Cardiac Myocytes;Cell Physiology;Cells;Chronic;Clinical;Coculture Techniques;critical limb Ischemia;Data;db/db mouse;Development;Diabetes Mellitus;diabetic;Diabetic mouse;diabetic patient;disability;Distant;Economic Burden;Endothelial Cells;endothelial stem cell;Endothelium;exosome;experimental study;Functional disorder;Genes;Goals;Growth;Hand;Health;Heart;Hindlimb;Human;human migration;Impairment;improved;In Vitro;in vivo;inhibitor;injury and repair;insight;Intramuscular Injections;Ischemia;Length;Lentivirus;limb injury;limb ischemia;Limb structure;Mediating;Metabolic Diseases;microRNA delivery;MicroRNAs;Molecular;Morbidity - disease rate;mortality;mouse model;Muscle;Muscle Cells;Muscle Fibers;Muscle function;Myocardial Infarction;novel therapeutic intervention;overexpression;paracrine;Pathogenesis;Pathway interactions;Patients;peripheral blood;Prevention strategy;Property;Proteins;Public Health;Publishing;Quality of life;repaired;Reporting;revascularization;Role;sex;Signal Pathway;Signal Transduction;Skeletal Muscle;Small Interfering RNA;social;stem cell biology;stem cell function;stem cell therapy;Testing;tissue injury;tissue repair;Tube;Vascular Endothelial Cell

PROJECT_TITLE: MyomiR-499, Exosomes and Endothelial and Endothelial Progenitor Cells dysfunction in Diabetes

STUDY_SECTION: BBHV

STUDY_SECTION_NAME: Basic Biology of Blood, Heart and Vasculature Study Section [BBHV]


ADMINISTERING_IC: AT

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Dietary Supplements;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: TUCSON

ORG_DEPT: NUTRITION

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: NARRATIVE Dietary fatty acid supplementation could be the most potentially effective dietary strategies to reduce critical diet- related health disparities; however, the under-representation of African American adults in studies of omega-3 (n-3) highly unsaturated fatty acid (HUFA) supplementation has obscured the staggering reductions in cardiovascular disease risk and other chronic disease outcome benefits in this historically underserved population. Our prior work shows that differences in genetic makeup leads to differential response to n-3-HUFA supplementation for African Americans and Non-Hispanic Whites. Here we propose to recruit African Americans and non-Hispanic Whites based on their genetic makeup, provide HUFA supplementation, and see if we can improve markers of inflammation and cardiovascular and metabolic disease risk.

PI_NAMEs: CHILTON, FLOYD H (contact);SCHEMBRE, SUSAN ;THOMSON, CYNTHIA A.

PROGRAM_OFFICER_NAME: WEBER, WENDY J

PROJECT_TERMS: Accounting;Acids;Address;Adult;African American;African American population;alpha-Linolenic Acid;American;Anti-Inflammatory Agents;Arachidonic Acids;Biological;Biological Markers;Carbon;cardiometabolism;cardioprotection;Cardiovascular Diseases;cardiovascular disorder risk;Chronic Disease;Clinical;clinical biomarkers;Clinical Trials;Communities;Cross-Over Trials;Data;desaturase;design;Diabetes Mellitus;Diet;dietary;Dietary Fatty Acid;dietary guidelines;Dietary intake;Disease;Disease Outcome;disorder risk;Docosahexaenoic acid supplementation;Docosahexaenoic Acids;Dose;Double-Blind Method;Effectiveness;Eicosapentaenoic Acid;Enzymes;Equilibrium;Ethnic Origin;European;experience;fatty acid biosynthesis;Fatty Acid Desaturases;fatty acid supplementation;Food production;Frequencies;Funding;Future;Gene Cluster;Genes;Genetic;genetic makeup;Genetic Variation;Genotype;Glucose;Health Benefit;health disparity;Heterogeneity;Human Genome;improved;Inflammatory;inflammatory marker;Inflammatory Response;Informatics;inhibitor;Institution;Insulin;Intake;Interleukin-6;Intervention;Laboratories;Lead;Link;Linoleic Acids;Linolenic Acids;lipid metabolism;Lipids;machine learning method;Malignant Neoplasms;marine;Metabolic;Metabolic Diseases;Metabolism;Methods;Modeling;multiple chronic conditions;Myocardial Infarction;N-3 polyunsaturated fatty acid;Not Hispanic or Latino;novel;Nutritional Study;Odds Ratio;Omega-3 Fatty Acids;Outcome;Participant;Pathway interactions;Phase;Phenotype;Placebo Control;placebo group;Placebos;Policies;Polyunsaturated Fatty Acids;Population;Populations at Risk;precision nutrition;prevent;protective effect;Race;racial difference;racial population;Randomized;recruit;Reduce health disparities;Research Design;response;retention rate;Risk;Running;secondary analysis;Serum;Signal Transduction;Site;Subgroup;Supplementation;Testing;thrombotic;TNF gene;treatment comparison;treatment group;Underserved Population;Unsaturated Fatty Acids;Variant;western diet;Work

PROJECT_TITLE: Addressing Diet-Induced Health Disparities with Precision Nutrition and Omega-3 Fatty Acids

STUDY_SECTION: NMHD

STUDY_SECTION_NAME: Nutrition and Metabolism in Health and Disease Study Section[NMHD]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Diabetes;Gene Therapy;Genetics;Human Genome;Nanotechnology;Regenerative Medicine;Wound Healing and Care

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: NARRATIVE The main goal of the application is to test the efficacy new biomaterials that release mRNA corresponding to genes shown to promote DFU healing in improving wound healing db/db diabetic mice, diabetic pigs, transplanted human skin onto immunocompromised mice and ex vivo human skin. Furthermore, we hypothesize that combination of various mRNAs with specific temporal delivery can physiologically imitate the activation of various pathways that are associated with DFU healing.

PI_NAMEs: MOONEY, DAVID J;VEVES, ARISTIDIS  (contact)

PROGRAM_OFFICER_NAME: LI, YAN

PROJECT_TERMS: 3-Dimensional;Adverse event;Alginates;Amputation;Animal Model;appropriate dose;Bandage;bench to bedside;Biocompatible Materials;Biodistribution;Cell Physiology;Cells;Characteristics;CHI3L1 gene;Chronic;Complications of Diabetes Mellitus;Data Set;db/db mouse;design;Development;Diabetes Mellitus;diabetic;Diabetic Foot Ulcer;Diabetic mouse;diabetic ulcer;diabetic wound healing;Disease;effective therapy;efficacy testing;Engraftment;experimental study;Family suidae;FGF2 gene;Fibroblasts;Functional disorder;Genes;Genetic Transcription;Goals;Growth Factor;healing;Health system;HIF1A gene;Human;human data;Hydrogels;IL17 gene;IL2 gene;IL6 gene;Immune;Immunocompromised Host;Impaired wound healing;Impairment;improved;in vivo;Individual;Inflammation;Inflammatory;innovation;insight;Interstitial Collagenase;lipid nanoparticle;Lower Extremity;Mediating;Messenger RNA;Methodology;Miniature Swine;MMP11 gene;MMP3 gene;Modality;Molecular;Molecular Mechanisms of Action;mRNA delivery;multiple omics;Mus;Names;nanoparticle delivery;novel therapeutic intervention;Nude Mice;Operative Surgical Procedures;overexpression;Pathway Analysis;Pathway interactions;Patients;Phase;Phase I/II Clinical Trial;Physiological;Population;pre-clinical;protein expression;Proteins;Research;Rodent;Severities;Signal Transduction;single-cell RNA sequencing;Skin;stromelysin 3;System;Therapeutic;therapeutic nanoparticles;Tissues;Toxic effect;transcriptomic profiling;translational study;Transplantation;Ulcer;Work;wound;wound healing;Wound models;wound treatment

PROJECT_TITLE: Use of Modified mRNA for the Treatment of Diabetic Foot Ulceration

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


NIH_SPENDING_CATS: Contraception/Reproduction;Genetics

ORG_CITY: HANOVER

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: Project Narrative The goal of this proposal is to provide insight into the cell division process of meiosis, which is essential for the formation of gametes, such as eggs or sperm. Errors in meiosis can cause a gain or loss of genetic material in the gametes, which can lead to miscarriage, infertility, and trisomy conditions. The experiments in this proposal address the fundamental question of how errors in meiosis occur so that we can learn how to prevent them.

PI_NAMEs: LACEFIELD, SONI  (contact)

PROGRAM_OFFICER_NAME: MILLER, RITA K

PROJECT_TERMS: Address;Affect;Age;Aneuploidy;Cell Cycle;Cell Cycle Regulation;Cell Division Process;Cells;Centromere;checkpoint modulation;Chromosome Arm;chromosome missegregation;chromosome number abnormality;Chromosome Segregation;Chromosomes;Complex;Cyclins;Data;Development;Diploid Cells;Diploidy;DNA;DNA biosynthesis;Down's Syndrome;egg;Embryo;Engineering;Ensure;Event;experimental study;Fertilization;Gametogenesis;Genetic Materials;Germ Cells;Goals;Haploidy;human female;Image;Imaging technology;Infertility;innovation;insight;Investigation;Kinetochores;Learning;Link;Location;Meiosis;Microtubules;Mitosis;Mitotic Chromosome;model organism;Monitor;novel;Phosphoric Monoester Hydrolases;Phosphotransferases;Positioning Attribute;prevent;Probability;Process;Production;Protein phosphatase;Proteins;Regulation;reproductive;Research;response;restraint;Role;Saccharomyces cerevisiae;Saccharomycetales;segregation;Signal Transduction;Sister Chromatid;Specificity;sperm cell;Spontaneous abortion;stem cells;System;Testing;Time;tool;Trisomy;Work

PROJECT_TITLE: Timing and regulation of meiotic commitment

STUDY_SECTION_NAME: Cell Structure and Function 1 Study Section[CSF1]


NIH_SPENDING_CATS: Bioengineering

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK STRUCTURAL BIOLOGY CENTER

ORG_STATE: NY

PHR: Project Narrative CryoEM has unique capabilities to study biological systems at atomic resolution that are not accessible to other structural methods. NCCAT provides a unified facility to lower the barriers to nationwide access to state-of-the- art equipment and technical support, to enable the production and analysis of high-resolution cryoEM structures. NCCAT will lead an educational program to engage and train the scientific community from neighboring fields to maximize the benefit for non-experts and expand the reach of the field while boosting the scientific output.

PI_NAMEs: DE MARCO, ALEX  (contact);ENG, EDWARD T;KIEFT, JEFFREY S

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TERMS: Address;base;biological systems;Biomedical Research;career;clinical practice;Communities;computerized data processing;Cryoelectron Microscopy;Custom;Data;data acquisition;Data Analyses;Data Collection;Dedications;detector;Diagnostic;Education;Educational Status;Educational workshop;Electron Microscopy;Ensure;Environment;Equipment;expectation;experience;Generations;Goals;Health;Human;human disease;image processing;improved;Infrastructure;instrument;instrumentation;Knowledge;Laboratories;Laboratory Research;Lead;Maps;Measures;Methods;Microscope;Modality;Modeling;Modernization;Molecular Structure;New York;New York City;novel therapeutics;operation;Output;particle;Preparation;Process;Production;programs;Qualifying;Quality Control;reconstruction;Research;Research Personnel;Resolution;Resources;Robot;Running;Sampling;Science;screening;screening program;screening services;service programs;Services;Side;Site;skills;Specimen;structural biology;Structure;Technology;Titan;Training;Training Activity;Training Programs;United States National Institutes of Health;Visit;Work

PROJECT_TITLE: NCCAT: National Center for CryoEM Access and Training

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MBBC-P (50)]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Immunotherapy;Skin Cancer

ORG_CITY: LEXINGTON

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: Project Narrative Melanoma, one of the most aggressive and fatal neoplasms, is the 5th most frequent cancer in men and 7th most frequent cancer in women and is responsible for over 80% of the skin cancer-related deaths. By investigating the role and mechanism of elongation factor-2 kinase (eEF-2K) as a novel immunomodulatory target and by assessing the antitumor efficacy of the eEF-2K-based integrative targeted therapy, we wish to provide innovative and effective immunotherapeutic strategies for patients with immune poor-responsive melanoma.

PI_NAMEs: SONG, JIANXUN JIM;YANG, JIN-MING  (contact)

PROGRAM_OFFICER_NAME: ZAMISCH, MONICA

PROJECT_TERMS: Adoptive Cell Transfers;Affect;B-Lymphocytes;BRAF gene;Ca(2+)-Calmodulin Dependent Protein Kinase;calmodulin-dependent protein kinase III;Cancer Biology;cancer immunotherapy;Cell Line;Cell Physiology;Cells;Cessation of life;Clinical;Clinical Research;conditional knockout;cytotoxic CD8 T cells;Cytotoxic T-Lymphocytes;Data;design;Development;Effectiveness;Elements;Energy Metabolism;Enzymes;Eragrostis;experimental study;Family;Goals;Human;humanized mouse;Immune;immune checkpoint blockade;Immune Evasion;immune function;immune resistance;Immunology;immunoregulation;Immunotherapeutic agent;Immunotherapy;improved;In Vitro;innovation;insight;Intervention;Knockout Mice;Macrophage;Major Histocompatibility Complex;Malignant Neoplasms;Melanoma;Melanoma Cell;Melanoma patient;men;Messenger RNA;Modeling;Molecular;Movement;Mus;mutant;Mutation;Neoplasms;neoplastic cell;novel;novel therapeutics;Organoids;Outcome;Patients;Peptides;Pharmacology;Phosphorylation;Phosphotransferases;preclinical study;Process;Productivity;Protein Biosynthesis;Proteins;Reaction;Refractory;Regulatory T-Lymphocyte;Research;Resistance;response;Ribosomes;Role;Safety;Site;Skin Cancer;Solid Neoplasm;Specimen;systems research;T-Lymphocyte;targeted treatment;Testing;Therapeutic;Therapeutic Studies;therapeutic target;therapeutically effective;therapy outcome;Translations;Treatment Efficacy;treatment response;treatment strategy;tumor;Tumor Antigens;Tumor Cell Line;Tumor Immunity;tumor-immune system interactions;Tumor-infiltrating immune cells;Woman

PROJECT_TITLE: Integrative Targeted Therapy for Melanoma

STUDY_SECTION: TIR

STUDY_SECTION_NAME: Therapeutic Immune Regulation Study Section[TIR]


ADMINISTERING_IC: AI

ED_INST_TYPE: GRADUATE SCHOOLS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_DEPT: GENETICS

ORG_NAME: ROCKEFELLER UNIVERSITY

PHR: NARRATIVE Currently available influenza vaccines provide protection only against circulating influenza strains and are totally ineffective against novel influenza strains that have the potential of causing pandemic outbreaks. Therefore, the development of a universal vaccine that will provide life-long protection against all influenza strains is urgently needed. The proposed studies aim to develop novel vaccines that will confer protection against all influenza strains through activation of specific immune pathways.

PI_NAMEs: PALESE, PETER ;RAVETCH, JEFFREY VICTOR (contact)

PROGRAM_OFFICER_NAME: GORDON, JENNIFER L

PROJECT_TERMS: 2019-nCoV;anti-influenza;Antibodies;Antibody Response;Antigen-Antibody Complex;Antigens;B-Lymphocytes;CD8-Positive T-Lymphocytes;Cell Maturation;Cellular Immunity;Clinical Trials;Complex;Dendritic Cells;design;Development;Disease Outbreaks;Effector Cell;Engineering;Epitopes;Evaluation;Fc domain;Foundations;Funding;Future;Glycoproteins;Head;Hemagglutinin;Human;Humoral Immunities;Immune;Immune response;Immunity;immunoengineering;immunogenicity;Immunoglobulin G;immunoregulation;in vivo;Influenza;Influenza Hemagglutinin;influenza infection;Influenza vaccination;influenza virus strain;influenza virus vaccine;innovation;Intramuscular;Licensing;Mediating;Messenger RNA;mosaic;Mouse Strains;Mucosal Immunity;Mus;novel;novel vaccines;pandemic disease;pandemic influenza;pathogenic virus;Pathway interactions;Population;preclinical evaluation;prevent;protective efficacy;receptor;Recombinant Proteins;response;Route;Sampling;Series;Serum;Structure of germinal center of lymph node;Surface;T cell response;T-Lymphocyte;Testing;Transgenic Mice;universal influenza vaccine;universal vaccine;Vaccination;vaccination strategy;vaccine access;Vaccine Design;vaccine formulation;vaccine platform;Vaccine Production;Vaccines;Viral;Virion

PROJECT_TITLE: Development of vaccination strategies to elicit broadly protective immunity against influenza

STUDY_SECTION: VID

STUDY_SECTION_NAME: Vaccines Against Infectious Diseases Study Section[VID]


NIH_SPENDING_CATS: Genetics;Hematology;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: SAINT LOUIS

ORG_DEPT: PEDIATRICS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Blood production requires precise regulation by transcription factors and epigenetic regulators, including transcriptional co-factors MLL3 and MLL4. Mechanisms that govern co-factor usage at one gene but not another remain ill-defined, yet they are critical for maintaining blood homeostasis. We propose experiments to define the mechanisms that govern usage of MLL3 and MLL4 to promote appropriate blood production.

PI_NAMEs: MAGEE, JEFFREY ALAN (contact)

PROGRAM_OFFICER_NAME: BAI, C BRIAN

PROJECT_TERMS: Address;Adopted;Adult;B-Cell Development;B-Lymphocytes;Binding;Binding Proteins;Binding Sites;Biochemical;Biological Assay;Blood;Body System;bone marrow failure syndrome;Cell Lineage;Cells;Chromatin;Cleavage Under Targets and Release Using Nuclease;cofactor;cohort;Complex;Development;Disease;DNA Binding;Enhancers;Epigenetic Process;epigenetic regulation;exhaustion;experimental study;Gene Expression;Gene Expression Regulation;Genes;Genetic;Genetic Enhancer Element;Genetic Transcription;Genetically Engineered Mouse;Genomics;Goals;Hematological Disease;Hematopoiesis;Hematopoietic;hematopoietic differentiation;hematopoietic stem cell self-renewal;Hematopoietic stem cells;Hematopoietic System;Histone H3;histone methyltransferase;Homeostasis;Human;Immune system;immunodeficiency;Inflammatory;insight;Learning;leukemia;Licensing;Logic;Lymphoid;Lysine;Malignant Neoplasms;Maps;Mediating;Methyltransferase;Multipotent Stem Cells;Mutate;Myelogenous;Positioning Attribute;Production;progenitor;programs;protein complex;Proteins;Proteomics;recruit;Regulatory Element;Role;SET Domain;Shapes;Techniques;Touch sensation;transcription factor;Transcriptional Regulation;Work

PROJECT_TITLE: The role of Kmt2c/MLL3 in hematopoietic stem cell self-renewal, commitment and exhaustion

STUDY_SECTION: HTBT

STUDY_SECTION_NAME: Hemostasis, Thrombosis, Blood Cells and Transfusion Study Section[HTBT]


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Heart Disease;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative Our preliminary data suggest that the social structure of care delivery—the pattern of social relationships, practices, and institutions determining the nature and context of care delivery—is a major contributor to SRD in HF care. The objective of this proposal is to address SRD in HF care by examining determinants of disparities and identifying stakeholder-informed areas of intervention within care delivery networks, which will inform a toolkit to enhance equitable HF care and outcomes. We have the following aims: (1) Evaluate the “social structure of care delivery” for populations disproportionately affected by SRD in HF care delivery and outcomes; (2) Develop a comprehensive understanding of structural barriers and facilitators for equitable HF care and outcomes; and (3) Develop a best practices toolkit to address SRD in HF care and outcomes.

PI_NAMEs: FUNK, RUSSELL ;LIKOSKY, DONALD S (contact);WATKINS, DAPHNE

PROGRAM_OFFICER_NAME: REDMOND, NICOLE

PROJECT_TERMS: Accounting;acute care;Address;Affect;American;Area;beneficiary;Black race;black women;Cardiovascular system;care coordination;care delivery;care outcomes;Caring;Chronic Disease;clinical practice;Clinical Practice Guideline;cohort;Collaborations;Communities;community engagement;Data;Data Analyses;design;Development;Diabetes Mellitus;Diagnosis;Disadvantaged;Discrimination;Disparity;disparity elimination;Epidemiology;Equity;ethnic minority;ethnic minority population;Ethnic Origin;Evaluation;evidence base;Focus Groups;follow-up;Goals;Guidelines;health care delivery;health data;health equity;health related quality of life;Health system;Healthcare;Heart failure;Hispanic;Hospitalization;Hospitals;Housing;Hypertension;implementation trial;insight;Institution;Intervention;intervention mapping;Interview;Maps;Medical;Medicare;Methods;Monitor;mortality;multidisciplinary;Nature;Nonpharmacologic Therapy;novel;Outcome;outcome disparities;Pathway Analysis;Patient risk;Patients;Pattern;PhenX Toolkit;Population;Prevalence;Productivity;Provider;Quality of life;Race;racial minority;racial minority population;Recommendation;Reduce health disparities;Risk;Risk Factors;Severities;sex;Shapes;social health determinants;Social Network;social relationships;social structure;Socioeconomic Status;Specialist;stakeholder perspectives;Strategic Planning;Structural Racism;Structure;System;Treatment Failure;United States National Institutes of Health;Woman;Work

PROJECT_TITLE: Addressing Structural Racism in Heart Failure Care and Outcomes: A Mixed Methods Evaluation of The Social Structure of Care Delivery

STUDY_SECTION: HHD

STUDY_SECTION_NAME: Healthcare and Health Disparities Study Section[HHD]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Genetics;Neurosciences

PHR: PROJECT NARRATIVE The establishment of highly precise neuronal connectivity is required for the proper functioning of the nervous system. Genetic disruptions affecting the development of the olfactory system in Kallmann or in CHARGE Syndromes profoundly and permanently disrupt olfactory function. Our goal in this project is to identify and understand the molecular mechanisms that are required for establishing normal neuronal connectivity in the developing olfactory system.

PI_NAMEs: RAPER, JONATHAN A (contact)

PROGRAM_OFFICER_NAME: SULLIVAN, SUSAN L

PROJECT_TERMS: Address;Affect;Afferent Neurons;Aging;Anosmia;Axon;axon guidance;Biological Models;Brain;Candidate Disease Gene;candidate identification;Categories;Cell secretion;Cell surface;CHARGE syndrome;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;Cues;Data Set;Development;Developmental Process;differential expression;Discrimination;early embryonic stage;Elements;Embryo;Embryonic Development;Epithelium;Event;experimental study;Family;Family member;Formulation;Genes;Genetic;genetic approach;Goals;Hand;Individual;knock-down;Knowledge;Label;Ligands;Location;member;Modeling;Molecular;mutant;Nervous System Physiology;neural circuit;Neurons;Neuropil;Neuropilins;Odorant Receptors;olfactory bulb;Olfactory Epithelium;Olfactory Pathways;olfactory sensory neurons;Patients;Pattern;Phenocopy;Play;Protein Secretion;receptor;receptor expression;recruit;regenerative therapy;repaired;Reproducibility;Research Proposals;Role;segregation;Semaphorins;Sensory;sensory system;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Study models;Subgroup;System;Systems Development;Technology;Testing;Time;transcriptome sequencing;Transgenes;Transgenic Organisms;Vertebrates;Visual;Work;Zebrafish

PROJECT_TITLE: Targeting of sensory axons in the olfactory bulb

STUDY_SECTION: NIC

STUDY_SECTION_NAME: Neuroscience of Interoception and Chemosensation Study Section[NIC]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Behavioral and Social Science;Cannabidiol Research;Cannabinoid Research;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Natural Products;Substance Misuse;Therapeutic Cannabinoid Research

ORG_CITY: MORGANTOWN

ORG_NAME: WEST VIRGINIA UNIVERSITY

ORG_STATE: WV

PHR: PROJECT NARRATIVE There is evidence that orally ingested cannabidiol, the non-psychoactive component of cannabis, has sedative- like effects, which could negatively impact driving performance, but limited research exists. The objective of this application is further our understanding of whether and how CBD may impact driving performance by dose and biological sex in a sample of young healthy adults using a driving simulator and a battery of well- validated self-report instruments and cognitive tests. Given that cannabidiol products are growing in popularity among all age groups in the United States, and their effects in a healthy population are virtually unknown, the positive impact of this study is the collection of essential data regarding the potential unintended consequences of this drug, which could put drivers and other road users at increased risk of motor vehicle collision.

PI_NAMEs: RUDISILL, TONI MARIE (contact)

PROGRAM_OFFICER_NAME: FEDOTA, JOHN RAPHAEL

PROJECT_TERMS: Address;Adult;Adverse effects;Aftercare;age group;aged;Appearance;Automobile Driving;biological sex;Cannabidiol;Cannabis;Cessation of life;Clinical;Clinical Trials;cognitive function;cognitive performance;cognitive testing;Collection;Consumption;Creativeness;Data;design;dosage;Dose;Double-Blind Method;driving performance;Drowsiness;Drug Kinetics;Education;Female;Food;Fostering;Future;General Population;Goals;hazard;Health;impaired driving performance;Impairment;improved;Individual;Injury;innovation;instrument;Knowledge;Lateral;Legal;male;Measures;Metabolism;Methodology;Methods;Mission;Morbidity - disease rate;mortality;Motor Vehicles;Neuropsychology;Oils;Oral;Oral Ingestion;Outcome;Participant;Patient Self-Report;Performance;Pharmaceutical Preparations;Pilot Projects;pilot trial;placebo controlled trial;Placebos;Population;Positioning Attribute;prevent;primary outcome;Product Labeling;Property;Public Health;Public Policy;Randomized;randomized, clinical trials;Reaction Time;recruit;Research;Risk;Safety;Sample Size;Sampling;Science;secondary outcome;Sedation procedure;sedative;sex;Sex Differences;sex variable;simulation;Statutes and Laws;Taste Perception;Testing;three-arm trial;Tobacco;United States;United States National Institutes of Health;Vehicle crash;virtual

PROJECT_TITLE: The Effects of Cannabidiol on the Driving Performance of Healthy Adults

STUDY_SECTION: HCMF

STUDY_SECTION_NAME: Human Complex Mental Function Study Section[HCMF]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Clinical Research;Disability Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Rehabilitation

ORG_CITY: DURHAM

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF NEW HAMPSHIRE

PHR: Project Narrative This project aims to develop and evaluate an automatic system for collecting and analyzing language data from individuals who use augmentative and alternative communication (AAC) devices. The research findings can potentially enhance AAC interventions by leveraging a smart finger ring and advanced computational methods, to collect and analyze AAC language data, resulting in more personalized and effective interventions. The findings can also provide a foundation for developing comprehensive databases to inform future AAC research and intervention strategies.

PI_NAMEs: CHEN, SZU-HAN K (contact)

PROGRAM_OFFICER_NAME: STORKEL, HOLLY LYNN

PROJECT_TERMS: Acceleration;Address;Algorithms;alternative communication;Artificial Intelligence;Augmentative and Alternative Communication;automated speech recognition;Biomedical Engineering;Caregivers;Child;Classification;Client;Clinical;Collection;Communication;communication device;Communication Research;Communities;complex data;Computing Methodologies;Consumption;Data;Data Analyses;data and analysis portal;Data Collection;data communication;data portal;Data Set;Databases;Development;Devices;effective intervention;Effectiveness;Ensure;Evaluation;feasibility testing;Foundations;Future;Genetic Transcription;Goals;high reward;high risk;improved;Individual;innovation;Intervention;Investments;Knowledge;Language;Learning;lexical;Linguistics;Machine Learning;machine learning algorithm;Measurement;Measures;Methods;Modeling;Monitor;Motivation;Nature;novel;Outcome;Output;Pathologist;Performance;personalized intervention;Persons;Population;Positioning Attribute;Procedures;Process;Psychometrics;Quality of life;Rehabilitation therapy;Research;Research Personnel;Ring Finger Domain;sample collection;Sampling;smart ring;Speech;Standardization;System;Systems Analysis;task analysis;Testing;Time;tool;touchscreen;Validity and Reliability;Vocabulary;Voice;wearable device;Work

PROJECT_TITLE: Breaking new ground in augmentative and alternative communication: developing wearable technology for automatic collection and analysis of language data using artificial intelligence

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


ADMINISTERING_IC: HD

ED_INST_TYPE: OTHER SPECIALIZED SCHOOLS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Violence Research;Youth Violence;Youth Violence Prevention

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Project Narrative This project tests intergenerational impacts of two different interventions (unearned cash transfers and social- cognitive skill building) in which the original child participants have been followed into adulthood and are now parenting their own children. This research will have high impact on public health by estimating the extent to which two forms of childhood interventions can affect family environments and child outcomes across generations. Risk and protective factors that disrupt intergenerational continuity in maladaptive parenting and child adjustment problems will be identified as potential future intervention targets, and lifespan developmental processes to inform future practice and policy decisions regarding promising proximal targets to reduce risk and improve children’s healthy development will be evaluated.

PI_NAMEs: DODGE, KENNETH A;LANSFORD, JENNIFER E (contact)

PROGRAM_OFFICER_NAME: ESPOSITO, LAYLA E

PROJECT_TERMS: 5 year old;Address;Adolescence;Adult;Affect;Age;age effect;aged;Aggressive behavior;American Indians;Behavior;Behavioral;Belief;Characteristics;Cherokee Indian;Child;Child Development;Child Mental Health;Child Rearing;Child Welfare;Childhood;cognitive skill;cohort;cost;County;criminal behavior;Data;Development;Developmental Process;Early Intervention;Education;Educational Curriculum;emerging adult;Environment;Ethnic Origin;Exhibits;Family;Fast Track intervention;food insecurity;Funding;Future;Generations;Heterogeneity;high risk;Home environment;improved;Income;Individual;innovation;intergenerational;Intervention;intervention effect;Investments;Life;life span;Longitudinal Studies;Measures;Mediating;Mediator;member;Mental Health;Natural experiment;next generation;North Carolina;offspring;Outcome;Parents;Participant;Policies;Population;prevent;preventive intervention;Process;protective factors;psychologic;Psychosocial Factor;Public Health;Race;Randomized;Randomized, Controlled Trials;Research;Risk Factors;Risk Reduction;Sampling;Shock;skills training;social;Social Processes;social skills;sociodemographics;substance use;Symptoms;teacher;Testing;Time;Training;Training Programs;tutoring;United States National Institutes of Health;Violence;violence prevention;young adult

PROJECT_TITLE: Intervention Impacts on Child Wellbeing and Parenting across Generations

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


NIH_SPENDING_CATS: Brain Disorders;Cancer;Childhood Leukemia;Down Syndrome;Hematology;Intellectual and Developmental Disabilities (IDD);Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: DETROIT

ORG_NAME: WAYNE STATE UNIVERSITY

PHR: Project Narrative Down syndrome (DS) children have a significantly higher risk of developing acute leukemias compared to non- DS children. The goal of this proposal is to determine the role of the DS bone marrow microenvironment in myeloid leukemia associated with DS (ML-DS) therapy response, furthering our understanding of the mechanisms underlying the extremely high cure rates of children with ML-DS. This proposal will also identify a novel treatment strategy of enhancing cytarabine treatment to further improve treatment outcome and reduce relapse of ML-DS patients.

PI_NAMEs: GE, YUBIN ;TAUB, JEFFREY WARREN (contact)

PROGRAM_OFFICER_NAME: KLAUZINSKA, MALGORZATA

PROJECT_TERMS: Activities of Daily Living;Acute;Acute leukemia;Acute Lymphocytic Leukemia;Acute Myelocytic Leukemia;Adherence;Affect;antileukemic activity;Aspartate;base;Blood Vessels;Bone Marrow;Cell Differentiation process;Cell Line;Cell Separation;Cells;Characteristics;Chemoresistance;chemotherapy;Child;Classification;Clinical Research;Cytarabine;Data;Deoxyribonucleotides;Development;Disease;Disease-Free Survival;Dose;Down's Syndrome;Endothelial Cells;Endothelium;Enzymes;FDA approved;Foundations;GATA1 gene;Goals;Growth;high risk;Histidine;hydroxyurea;improved;improved outcome;In Vitro;in vivo Model;Knowledge;leukemia;Leukemic Cell;leukemogenesis;Link;Literature;Mediating;Megakaryocytes;Molecular;Mutation;Myeloid Leukemia;novel;Outcome;patient population;Patient-Focused Outcomes;Patients;Pediatric Oncology Group;Phenotype;Population Heterogeneity;prevent;Process;Proteins;Protocols documentation;Relapse;relapse prevention;relapse risk;Reporting;Research;research clinical testing;Residual Neoplasm;Resistance;response;Ribonucleotide Reductase;Ribonucleotide Reductase Inhibitor;Ribonucleotides;Risk;Risk Reduction;Role;Safety;Salvage Therapy;SAM Domain;Signal Transduction;Solid;Stem cell transplant;Subgroup;Survival Rate;Testing;Tissues;Translating;Treatment outcome;treatment response;treatment strategy;tripolyphosphate

PROJECT_TITLE: Enhancing treatments for myeloid leukemia associated with Down syndrome

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IVBH-B (57)]


ORG_CITY: MADISON

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Narrative The proposed studies will expand the types of C(sp2)–C(sp3) bonds that can be made, increasing the diversity of molecules that can be readily accessed. This is relevant to the public health mission of the NIH because it is from the pool of available molecules that future drugs will be discovered. A larger pool of molecules with greater three-dimensional character increases the odds of finding the best treatments with the fewest side effects.

PI_NAMEs: WEIX, DANIEL JOHN (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TERMS: 3-Dimensional;Address;Alcohols;Alkenes;Amines;Ancillary Study;Area;Automobile Driving;Biological;Carbon;Carboxylic Acids;catalyst;chemical synthesis;Chemicals;Chemistry;Chlorides;Cobalt;Collection;Complex;cost;Coupling;Development;DNA;drug candidate;drug development;drug discovery;Future;Generations;Goals;graduate student;Grant;improved;In Situ;Industrialization;innovation;interest;Isomerism;Libraries;Ligands;method development;Methods;Mission;Modern Medicine;Nature;Nickel;novel strategies;novel therapeutics;Organic Synthesis;Pharmaceutical Chemistry;Pharmaceutical Preparations;Pharmacologic Substance;Postdoctoral Fellow;Process;programs;Property;Protocols documentation;protonation;Public Health;Reaction;Research;Research Proposals;side effect;Source;Structure;success;tool;United States National Institutes of Health;uptake

PROJECT_TITLE: Cross-Electrophile Coupling for C(sp2)–C(sp3) Bond Formation: Broadened Access to Abundant Electrophiles, Solutions to Challenging Couplings, and Improved Mechanistic Understanding

STUDY_SECTION: CSB

STUDY_SECTION_NAME: Chemical Synthesis and Biosynthesis Study Section[CSB]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_CITY: MILWAUKEE

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

PHR: NARRATIVE Chronic lack of sleep places people at risk for bone loss and bone fragility that characterize osteoporosis, an age-related, debilitating disease affecting millions of U.S. men and women and which can lead to lost independence and early death. The proposed research is relevant to public health because it will define the biology of chronic sleep deficiency—how it changes bone structure and remodeling activities that underlie bone fragility and fracture risk, using a validated animal model. The knowledge gained will be a foundation for translational research aimed at reducing age-related morbidity imposed by chronic sleep deficiency.

PI_NAMEs: EVERSON, CAROL A (contact);TOTH, JEFFREY MICHAEL

PROGRAM_OFFICER_NAME: WILLIAMS, JOHN

PROJECT_TERMS: Acceleration;Address;Adrenal Cortex Hormones;Adrenergic Agents;Adult;Affect;Age;age related;age related changes;age-related disease;aged;Aging;aging related disease;Animal Model;antagonist;Awareness;beta-adrenergic receptor;Biological;Biology;biomechanical test;bone;bone cell;Bone Density;Bone Diseases;bone fragility;bone health;bone loss;bone mass;bone metabolism;bone quality;Bone remodeling;Bone Resorption;Bone structure;bone turnover;Calories;cardiovascular risk factor;Cessation of life;Chronic;circadian;Circadian Rhythms;Clinical;clinical research site;cohort;comparative;Contralateral;Data;Deterioration;disability;Disease;disorder risk;Environmental Exposure;Epidemiology;Etiology;Female;Foundations;Fracture;fracture risk;Glucose Intolerance;Goals;Health;Hindlimb;Hormonal;Human;Immature Bone;Impairment;improved;in vivo;innovation;insight;Intervention;Knowledge;Life;life span;male;Mature Bone;mechanical load;Mediating;Medical;meetings;men;Metabolism;middle age;Modeling;Molecular;Morbidity - disease rate;nerve supply;neural;novel;older adult;Operative Surgical Procedures;Osteogenesis;Osteopenia;Osteoporosis;Osteoporotic;Outcome;Pathogenesis;Pathology;Pattern;Phenotype;Populations at Risk;premature;Process;Public Health;Rattus;repaired;Research;response;Risk Factors;Role;Science;Serum Markers;sexual dimorphism;shift work;Site;skeletal;Skeleton;Sleep;Sleep Deprivation;spine bone structure;substantia spongiosa;Surveys;Sympathectomy;Sympathetic Nervous System;Testing;Time;Translational Research;Woman;Work

PROJECT_TITLE: Chronic sleep deficiency as a cause of bone loss in aging

STUDY_SECTION: SBDD

STUDY_SECTION_NAME: Skeletal Biology Development and Disease Study Section[SBDD]


ORG_CITY: FARMINGTON

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT

ORG_STATE: CT

PHR: PUBLIC HEALTH RELEVANCE New antibiotics that can act against gram-negative pathogens are limited and new therapeutic approaches are urgently needed. We aim to discover approaches to sensitize antibiotic-tolerant Escherichia coli and Pseudomonas aeruginosa to existing topoisomerase inhibitors along with compounds that are in clinical trials. We will investigate phenotypic changes that underlie bacterial survival in the presence of these drugs and as cells recover after antibiotic treatment terminates, which will enable us to develop strategies that thwart the evolution of antibiotic treatment failure and resistance development.

PI_NAMEs: MOK, WENDY W.K. (contact)

PROGRAM_OFFICER_NAME: XU, ZUOYU

PROJECT_TERMS: Acceleration;Affect;Antibiotic Resistance;Antibiotic Therapy;antibiotic tolerance;Antibiotics;antimicrobial;Antimicrobial Resistance;Bacteria;bacterial metabolism;bacterial resistance;Cell Death;Cell Separation;Cells;Cessation of life;Clinic;Clinical Trials;Coin;Complement;Development;differential expression;DNA;DNA Damage;DNA Repair;DNA Repair Gene;DNA Topoisomerases;Dose;Drug Efflux;effectiveness evaluation;efflux pump;Energy Metabolism;Enzymes;Escherichia coli;Event;Evolution;experimental study;Fluorescence Microscopy;Fluorescent Probes;Fluoroquinolones;Gene Deletion;Generations;Genes;Growth;Heritability;ineffective therapies;Infection;insight;Knowledge;Liquid Chromatography;Measures;Metabolic;Metabolism;Methods;Microfluidics;microorganism;Molecular;Monitor;Mutagenesis;Mutation;novel therapeutic intervention;novel therapeutics;nucleic acid metabolism;Nucleic Acids;pathogen;Pathway interactions;persistent bacteria;Pharmaceutical Preparations;Phase;Phenotype;Population;preservation;Process;Production;programs;Proton-Motive Force;Pseudomonas aeruginosa;Public Health;public health relevance;Recovery;recurrent infection;Refractory;Relapse;repaired;Reporter Genes;Research;Resistance;Resistance development;Respiratory Tract Infections;Resuscitation;Role;Site;Starvation;success;tandem mass spectrometry;Testing;therapeutic development;therapy resistant;Topoisomerase;Topoisomerase Inhibitors;transcriptome sequencing;Treatment Failure;Urinary tract infection;Work

PROJECT_TITLE: Bacterial Reprogramming that Contributes to Antibiotic Persistence toward Topoisomerase Inhibitors

STUDY_SECTION: AIRT

STUDY_SECTION_NAME: Anti-Infective Resistance and Targets Study Section [AIRT]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Cancer;Childhood Leukemia;Hematology;Machine Learning and Artificial Intelligence;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: CAMBRIDGE

ORG_DEPT: MISCELLANEOUS

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

PHR: Narrative The persistence of minimal or measurable residual disease (MRD) is considered to be a key determinant of relapse and poor patient prognosis in acute myeloid leukemia (AML). The current clinical strategy at complete remission with MRD positivity is, depending on the level, to either provide additional dose(s) of the initial treatment or switch to a new therapy at the time of relapse. Through the use of a novel single-cell assay developed by an industry/academic partnership, we are proposing to instead target MRD by selecting a more optimal therapy before relapse.

PI_NAMEs: HEMANN, MICHAEL ;LANE, ANDREW A;MANALIS, SCOTT R (contact)

PROGRAM_OFFICER_NAME: OSSANDON, MIGUEL

PROJECT_TERMS: Academia;Acute Myelocytic Leukemia;Antitumor Drug Screening Assays;Artificial Intelligence;Automobile Driving;Benchmarking;Biological Assay;biophysical analysis;biophysical properties;Bone Marrow;cancer cell;Cell Separation;Cells;Cellular Assay;Cellular Morphology;Chemoprotective Agent;chemotherapy;Chemotherapy-Oncologic Procedure;Clinical;cloud software;Computer Vision Systems;Data;deep learning;design,build,test;Devices;Disease;Disease remission;Dose;drug sensitivity;experience;Future;Goals;Hematopoietic;Heterogeneity;Image;Immunofluorescence Immunologic;In complete remission;Industry;Infiltration;innovation;Investments;Label;leukemia;Liquid substance;Machine Learning;Malignant - descriptor;Malignant Neoplasms;manufacture;Measurable;Measures;Microfluidics;Morphology;neoplastic cell;novel;novel therapeutics;Optics;optimal treatments;patient prognosis;Patients;Performance;Pharmaceutical Preparations;Pharmacotherapy;Prediction of Response to Therapy;Recurrent disease;Relapse;Reproducibility;Residual Neoplasm;Resources;response;Sampling;side effect;skills;Sorting;Specificity;Specimen;System;Testing;Therapeutic;Time;tool;Tumor Burden

PROJECT_TITLE: Targeting minimal residual disease in AML by using single-cell morphological and biophysical analysis with deep learning

STUDY_SECTION: BDMA

STUDY_SECTION_NAME: Biodata Management and Analysis Study Section[BDMA]


NIH_SPENDING_CATS: Biotechnology;Cancer;Ovarian Cancer;Rare Diseases;Women's Health Research

ORG_NAME: RESEARCH INST OF FOX CHASE CAN CTR

PHR: High-grade serous ovarian carcinoma (HGSOC) is the deadliest form of ovarian cancer due to frequent recurrence and metastasis with minimal treatment options. Recurrent HGSOC often spreads to the peritoneal cavity in the form of ascites, where tumor cells grow as spheroids, and metastasize to other organs causing death. The overall goal of this proposal is to uncover how protein kinases orchestrate this process, so that we can design kinase inhibitor therapies to prevent the growth and spread of recurrent HGSOC.

PI_NAMEs: DUNCAN, JAMES STUART (contact)

PROGRAM_OFFICER_NAME: O'HAYRE, MORGAN

PROJECT_TERMS: Actins;Apoptosis;Ascites;Binding;cancer cell;Cancer cell line;Cancer Model;Cause of Death;cell motility;Cessation of life;Clinical;Communication;Cytoskeletal Modeling;Cytoskeleton;design;Disease;Drug Targeting;Event;Focal Adhesions;Genetic;Goals;Greater sac of peritoneum;Growth;Guanine;Guanine Nucleotide Exchange Factors;Impairment;In Vitro;in vivo;inhibitor therapy;insight;Invaded;kinase inhibitor;knock-down;Knowledge;Malignant neoplasm of ovary;Maps;Mass Spectrum Analysis;Measures;Mediating;Metastatic Malignant Neoplasm to the Ovary;Methods;Modeling;Monitor;Morbidity - disease rate;Myosin ATPase;Neoplasm Metastasis;neoplastic cell;new therapeutic target;novel;Organ;Organoids;ovarian neoplasm;Ovarian Serous Adenocarcinoma;Pathogenesis;patient derived xenograft model;Patients;Phase;Phosphorylation;Phosphorylation Site;Phosphotransferases;prevent;Process;Proliferating;Protein Kinase;protein protein interaction;Proteins;Proteomics;Recurrence;Regulation;rho;ROCK1 gene;Role;Signal Pathway;Signal Transduction;Site-Directed Mutagenesis;small molecule;spheroids;Testing;Therapeutic;three dimensional cell culture;Translating;tumor;tumor growth;Work;Xenograft procedure

PROJECT_TITLE: Interrogating MRCK Protein Kinases in Ovarian Cancer

STUDY_SECTION: TEHM

STUDY_SECTION_NAME: Tumor Evolution, Heterogeneity and Metastasis Study Section[TEHM]


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Services;Hypertension;Prevention;Telehealth

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Project Narrative: PT4A (Peers and Technology for Adherence, Access, Accountability, and Analytics) Elevated blood pressure is the leading risk for mortality worldwide; despite numerous evidence-based practices to optimize medication adherence, substantial implementation gaps persist, and medication non- adherence is a major cause of uncontrolled hypertension and cardiovascular morbidity and mortality. This project aims to improve hypertension medication adherence, thereby improving blood pressure control, by evaluating a novel implementation strategy combining peer-based medication delivery and health information technology. The findings from the project will add to the existing knowledge base on innovative and scalable strategies for improving medication adherence for hypertension control, especially for low-resource settings worldwide.

PI_NAMEs: NJUGUNA, BENSON NG'ANG'A;VEDANTHAN, RAJESH  (contact)

PROGRAM_OFFICER_NAME: WILLIAMS, MAKEDA J

PROJECT_TERMS: Accountability;Address;Adherence;arm;Award;Biological;Blood Pressure;blood pressure control;blood pressure elevation;blood pressure reduction;budget impact;Cardiovascular Diseases;Cardiovascular system;Caring;Chronic Disease;Clinical;clinical care;Collaborations;cost;cost effectiveness;Counseling;Data;Disease Outcome;Dose;Effectiveness;effectiveness evaluation;Ensure;Evaluation;Evidence based practice;Funding;Guidelines;Health;health information technology;Health system;hybrid type 2 trial;Hypertension;hypertension control;implementation measures;implementation outcomes;implementation research;implementation strategy;improved;informatics infrastructure;innovation;Insurance;Intervention;Kenya;Knowledge;knowledge base;Lead;Literature;Mediating;medication compliance;medication nonadherence;Morbidity - disease rate;mortality;mortality risk;novel;opportunity cost;Outcome;Patient Self-Report;Patients;peer;peer coaching;peer support;Pharmaceutical Preparations;Pharmacy facility;pill;premature;Productivity;programs;Psychosocial Assessment and Care;Randomized;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Regimen;Reporting;Research;Research Personnel;Research Project Grants;Resource-limited setting;secondary outcome;supply chain;Technology;teleconsultation;Testing;Time;Transportation;Travel;Trust;United States National Institutes of Health;Work

STUDY_SECTION: CMGC

STUDY_SECTION_NAME: Clinical Management in General Care Settings Study Section[CMGC]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

ORG_CITY: BOSTON

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

PHR: PROJECT NARRATIVE Our work has the potential to dramatically impact public health because by determining the influence of the lymph node microenvironment on lipidomic changes in melanoma, we will be able to 1.) identify feasible lipidomic targets to prevent death from cancer spread from lymph nodes and 2.) determine lipids in melanoma cells that serve as prognostic biomarkers for metastasis and thus identify patients who could be spared the side effects of undergoing surgical resection of lymph nodes. Furthermore, we will elucidate how lipids modulate the lymphatic microenvironment to influence melanoma metastasis, which will offer important evidence linking lipid usage to risk of melanoma progression. Our work will provide the groundwork for future research efforts to develop novel therapeutic strategies to prevent progression of early-stage melanoma, with applicability to other cancer types as well (e.g., prostate, lung, breast cancer) by modulating the lymphatic microenvironment.

PI_NAMEs: UBELLACKER, JESSALYN  (contact)

PROGRAM_OFFICER_NAME: WATSON, JOANNA M

PROJECT_TERMS: Acids;Acyl Coenzyme A;Acyltransferase;Biological;Biology;Blood;cancer cell;Cancer Prognosis;cancer type;carcinogenesis;Cause of Death;Cell Death;cell killing;Cell Survival;Cells;Cessation of life;circulating cancer cell;Clinical;clinically relevant;Diet;dietary;Dietary Fats;Dietary Fatty Acid;Dietary Intervention;Disease Outcome;Distant Metastasis;draining lymph node;effective therapy;Environment;Esters;Excision;Fatty Acids;Generations;Genetic;Glycine;Human;Hydrogen;Immunocompetent;improved;Intervention;Knowledge;Link;lipid metabolism;lipidomics;Lipids;Lung;Lymph;lymph node microenvironment;lymph nodes;Lymphatic;Lymphocyte;Malignant Breast Neoplasm;Malignant Neoplasms;Melanoma;Melanoma Cell;Membrane;Metabolic;Metastatic Melanoma;Metastatic Neoplasm to Lymph Nodes;metastatic process;Methods;Modeling;Monounsaturated Fatty Acids;mortality;mouse model;Mus;Neoplasm Metastasis;novel;novel therapeutic intervention;Oleic Acids;Operative Surgical Procedures;oxidation;Oxidation-Reduction;Oxidative Stress;Oxidoreductase;Pathway interactions;patient derived xenograft model;Patients;perhydroxyl radical;pharmacologic;Polyunsaturated Fatty Acids;prevent;Primary Neoplasm;Process;Production;Prognostic Marker;Prostate;Proteins;Public Health;Reactive Oxygen Species;Research;Resistance;Risk;Role;Sampling;Side;side effect;Stearoyl-CoA Desaturase;Testing;tumor metabolism;tumor progression;Work;Xenograft Model

PROJECT_TITLE: Preventing Melanoma Metastasis by Targeting Lipid Vulnerabilities in Lymph

STUDY_SECTION: THI

STUDY_SECTION_NAME: Tumor Host Interactions Study Section[THI]


ORG_CITY: WALTHAM

ORG_NAME: BRANDEIS UNIVERSITY

PHR: Project Narrative This proposal explores the evolutionary mechanisms by which proteins have gained novel functions in a medically important class of enzymes, the malate and lactate dehydrogenases (MDHs and LDHs). Due to their significant differences from the human MDH enzymes, many of the bacterial MDH enzymes are important potential drug targets, including human pathogens such as cryptosporidiosis, malaria, anthrax, Bacteroides, and Pseudomonas. The results of this research will aid in answering several long-standing evolutionary questions and will aid our understanding of how enzymatic functions can be engineered.

PI_NAMEs: THEOBALD, DOUGLAS LOWELL (contact)

PROGRAM_OFFICER_NAME: BARSKI, OLEG

PROJECT_TITLE: Evolution of enzyme function, mechanism, dynamics, and structure viewed at atomic resolution

STUDY_SECTION: GVE

STUDY_SECTION_NAME: Genetic Variation and Evolution Study Section[GVE]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Contraception/Reproduction;Genetics;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: PULLMAN

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: WASHINGTON STATE UNIVERSITY

ORG_STATE: WA

PHR: Project Narrative: The production of spermatozoa in the testis is regulated by coordinated interactions between the germ cells and the somatic Sertoli cells. The nature of these cellular interactions and their molecular signaling systems will be explored.

PI_NAMEs: GRISWOLD, MICHAEL D (contact)

PROGRAM_OFFICER_NAME: KENT, TRAVIS JOHN

PROJECT_TERMS: Ablation;Adult;Affect;Anabolism;Appearance;Attention;Cell Communication;Cell Maturation;Cell Physiology;Cells;Characteristics;Data Set;Development;Enhancers;Etiology;experience;Gene Deletion;Gene Expression;gene product;gene synthesis;Generations;Genes;Genetic Transcription;Germ Cells;hormone regulation;insight;interest;Ligands;Location;Male Infertility;Mammals;Mediating;Meiosis;Molecular;Mus;Nature;new technology;notch protein;Notch Signaling Pathway;Pathway interactions;Periodicals;Periodicity;Physiologic pulse;Play;Postpartum Period;Process;Production;promoter;Recurrence;Regulatory Element;Regulatory Pathway;Residual state;Role;Seminiferous tubule structure;sertoli cell;Signal Transduction;single-cell RNA sequencing;Somatic Cell;Source;sperm cell;Spermatids;Spermatogenesis;spermatogenic epithelium structure;Spermatogonia;stem cells;System;Technology;Testing;Testis;Tight Junctions;Time;Transcript;transcription factor;Transcription Initiation;Transcription Initiation Site;transcription regulatory network;transcriptome;transcriptome sequencing;Tretinoin;Undifferentiated;uptake;Vitamin A;Wild Type Mouse

PROJECT_TITLE: Hormonal Regulation Sertoli Cell Maturation

STUDY_SECTION: CMIR

STUDY_SECTION_NAME: Cellular, Molecular and Integrative Reproduction Study Section[CMIR]


ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Narrative We will utilize high pressure (50-100Atm) to dissolve adequate volumes of oxygen in saline to make a clinically relevant therapy to sustain body oxygen requirements for up to 10-20 min/L of saline infused. We will create a solution consisting of nanobubbles and saline to be mixed with the returning venous blood and test its effect on blood oxygenation in a porcine model of cardiac arrest. Success of this project will open new horizons in the management of multiple human disease emergencies.

PI_NAMEs: YANNOPOULOS, DEMETRIS  (contact)

PROGRAM_OFFICER_NAME: DANTHI, NARASIMHAN

PROJECT_TERMS: absorption;Acute;Adult;Air Embolism;Anesthesia procedures;Animal Model;Biological Assay;Blood;Blood flow;Blood gas;Brain Ischemia;Cardiac Death;Cardiovascular system;Cells;Cessation of life;Characteristics;Child;Circulation;Clinical;clinically relevant;clinically significant;cold temperature;Contusions;Diameter;Disease;emergency service responder;Emergency Situation;Engineering;Evolution;Extracorporeal Circulation;Extracorporeal Membrane Oxygenation;Family suidae;Free Radicals;Fright;Gases;Generations;Heart;Heart Arrest;hemodynamics;Hemoglobin;Hemorrhage;Histologic;Hospitals;Hour;Human;human disease;Hyperoxia;Hypoxemia;Hypoxemic Respiratory Failure;Hypoxia;Impairment;improved;improved outcome;Infusion procedures;Injury;Intervention;Intravenous;Intravenous infusion procedures;intravenous injection;Intubation;invention;Ischemia;Lasers;Lead;Lung;Measures;Methods;Microcirculation;Mitochondria;Modeling;Molecular;Monitor;Morbidity - disease rate;mortality;nanobubble;nanoparticle;Neurological outcome;normotensive;novel;Obstruction;Organ;out-of-hospital cardiac arrest;Oxygen;oxygen transport;patient population;Patients;Perfusion;Physics;Population;porcine model;pressure;prevent;Process;Public Health;Pulmonary Edema;Quality of life;Reactive Oxygen Species;Refractory;Residual state;Rest;Resuscitation;Risk;Saline;side effect;success;Techniques;Temperature;Testing;Time;tissue oxygenation;Tissues;Tube;United States;uptake;Veins;Venous;ventilation;Vision;Water

PROJECT_TITLE: Nanobubble oxygenation in cardiac arrest and acute vital organ ischemia

STUDY_SECTION: TDPS

STUDY_SECTION_NAME: Therapeutic Development and Preclinical Studies Study Section[TDPS]


ORG_CITY: SAN ANTONIO

ORG_DEPT: UROLOGY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

ORG_STATE: TX

PHR: PROJECT NARRATIVE Urinary bladder cancer results in over 17,000 estimated deaths per year in the U.S. This proposal will address a significant gap in current knowledge of chemotactic mechanisms driving the immune cell recruitment and growth of bladder tumors and will facilitate the development of a novel bladder cancer treatment strategy.

PI_NAMEs: MUKHERJEE, NEELAM  (contact)

PROGRAM_OFFICER_NAME: ZAMISCH, MONICA

PROJECT_TERMS: Address;Amino Acids;anti-PD-1;anti-PD-L1;antitumor effect;Automobile Driving;Award;BCG Live;beta-Chemokines;Binding;Biological Assay;Biological Markers;Biology;Bladder;Bladder Neoplasm;cancer immunotherapy;Cancer Model;Cancer Patient;cancer recurrence;cancer therapy;Cells;Cessation of life;chemokine;chemokine receptor;Clinical;Clinical Trials;clinically significant;cohort;cytotoxicity;Data;Development;Diagnosis;Equipment and supply inventories;Exhibits;Failure;Flow Cytometry;gemcitabine;Glutamic Acid;Growth;Growth and Development function;Human;Immune;immune cell infiltrate;immune checkpoint blockers;Immunity;Immunofluorescence Immunologic;Immunotherapy;improved;In complete remission;inhibitor;intravesical;Intravesical Instillation;Knowledge;Ligands;lymph nodes;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Mass Spectrum Analysis;Mediating;Methods;migration;Minority;Modeling;monocyte chemoattractant protein 1 receptor;mouse model;Mus;mutant;Mutate;Myeloid Cells;Myeloid-derived suppressor cells;neoplastic cell;nitration;novel;Pathway interactions;patient stratification;Patient-Focused Outcomes;Patients;Peroxonitrite;Phenotype;Prediction of Response to Therapy;Production;Prognostic Factor;Property;protective effect;Proteins;Reactive Nitrogen Species;receptor;Recombinants;recruit;Recurrence;Research;Research Design;Research Personnel;Resistance;response;Role;Sampling;Selection for Treatments;Signal Transduction;single-cell RNA sequencing;Solid Neoplasm;Surface;synergism;T-Lymphocyte;Testing;The Cancer Genome Atlas;Therapeutic;Therapeutic Intervention;Tissue Microarray;Tissues;trafficking;treatment effect;treatment response;treatment strategy;tumor;tumor ablation;tumor growth;Tumor Immunity;tumor immunology;tumor microenvironment;tumor progression;Tumor Promotion;Tumor stage;Tumor-infiltrating immune cells;tumorigenic;Tyrosine

PROJECT_TITLE: Novel mechanism of chemokine nitration in bladder cancer

STUDY_SECTION: CIC

STUDY_SECTION_NAME: Cellular Immunotherapy of Cancer Study Section[CIC]


NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Genetics;Macular Degeneration;Neurodegenerative;Neurosciences;Women's Health Research

ORG_CITY: WASHINGTON

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: GEORGETOWN UNIVERSITY

ORG_STATE: DC

PHR: NARRATIVE:  This proposal addresses critical issues of central importance to advance our understanding of the mechanisms of age-related decline in visual system. Those include: investigating how sex could play a critical role in RPE, retina and visual cortex functions during aging and how sex chromosomes, sex hormones, or their interactions could regulate the visual system function. The results and conclusions derived from this study will provide important information for better understanding the age-related changes in the visual system and will further our knowledge of how aging, sex chromosomes, and gonadal sex contribute to the visual system function during aging.

PI_NAMEs: FIRESTEIN, BONNIE L;GOLESTANEH, NADY  (contact)

PROGRAM_OFFICER_NAME: ST  HILLAIRE-CLARKE, CORYSE

PROJECT_TERMS: 11 cis Retinal;Acute;Address;Affect;Age;age related;age related changes;age related decline;Age related macular degeneration;aged;Aging;aging mechanism;Animals;Biochemical;Blindness;Cells;college;Complement Factor B;Data;Dendrites;Development;Disease;Drusen;Dryness;effective therapy;Elderly;Electron Microscopy;Electroretinography;Female;Fibrinogen;Four Core Genotypes;Fractionation;Functional disorder;Golgi Apparatus;Gonadal Hormones;Gonadal Steroid Hormones;Guidelines;Health;High Prevalence;hormone deficiency;Hormone secretion;Hormones;immunocytochemistry;in vivo;Knowledge;Lateral Geniculate Body;Life Expectancy;Light;Macular Hole;Maintenance;male;Medical;men;Metabolism;Microelectrodes;middle age;Mitochondria;Modeling;Morphology;Mus;Neurons;novel therapeutics;Ophthalmologist;Optic tract structure;Optical Coherence Tomography;Outcome;Phagocytes;Phenotype;Photoreceptors;Play;Ploidies;Postmenopause;Proteins;Reporting;Retina;Retinal Degeneration;Retinal Diseases;Retinal Ganglion Cells;retinal neuron;Risk;Risk Factors;Role;Secondary to;sex;Sex Chromosomes;Sex Differences;sex risk;Slice;Structure;Structure of retinal pigment epithelium;Synapses;Synaptosomes;System;Testing;Trichrome stain;Vision;Vision Disparity;Visual;Visual Acuity;Visual Cortex;visual cycle;visual information;visual processing;Visual System;Woman;women versus men

PROJECT_TITLE: Sex-dependent aging mechanisms of retina and visual cortex

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza;Prevention

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative The antibiotic resistant ESKAPE pathogens, the major cause of health care associated pneumonia, activate the production of itaconate and fumarate in the airway. Itaconate activates anti-inflammatory and anti-oxidant responses in the host, which protect against tissue damage due to excessive oxidant stress, but also interfere with effective bacterial killing. We will establish how itaconate and fumarate orchestrate both airway defenses and bacteria adaptation in the pathogenesis of pneumonia.

PI_NAMEs: PRINCE, ALICE S (contact)

PROGRAM_OFFICER_NAME: MONGODIN, EMMANUEL FRANCK

PROJECT_TERMS: activating transcription factor 3;Address;Affect;Anti-Inflammatory Agents;Antibiotic Resistance;Antioxidants;Automobile Driving;Bacteria;Bacterial Antibiotic Resistance;Bacterial Genes;Bacterial Infections;Bacterial Pneumonia;Bacterial Proteins;Carbon;Cell Physiology;Cells;chronic infection;Citric Acid Cycle;Clinical;clinically relevant;Cysteine;Data;Data Set;dicarboxylate;Environment;Equilibrium;ESKAPE pathogens;Evaluation;experimental study;Fumarates;Gene Expression;Genetic Transcription;Genotype;Goals;Gram-Negative Bacteria;Healthcare;Hospitalization;Host Defense;Hour;Immune;Immune response;Impairment;in vivo;in vivo Model;Infection;Inflammation;Inflammatory Response;Inhalation;Klebsiella pneumoniae;Learning;Link;Lung;Lung infections;lung pathogen;Macrophage;Metabolic;Metabolic Pathway;Metabolism;metabolome;metabolomics;Microbial Biofilms;Modeling;Modification;monocyte;Morbidity - disease rate;mortality;mouse model;Mus;Myeloid-derived suppressor cells;Nature;Nosocomial pneumonia;Organism;oxidant stress;Oxidants;Participant;pathogen;Pathogenesis;Pathway Analysis;Pathway interactions;Patients;personalized medicine;Phagocytes;Phenotype;Pneumonia;Post-Translational Protein Processing;Predisposition;prevent;Production;Proliferating;Proline;Proteomics;Pseudomonas aeruginosa;Pseudomonas aeruginosa infection;Pseudomonas aeruginosa pneumonia;recruit;Repression;Respiratory Tract Infections;response;Role;Sepsis;Shapes;Signal Transduction;single-cell RNA sequencing;Site-Directed Mutagenesis;Source;Staphylococcus aureus;System;Testing;Tissues;Toxic effect;transcription factor

PROJECT_TITLE: Airway metabolites shape susceptibility to pneumonia

STUDY_SECTION: BHI

STUDY_SECTION_NAME: Bacterial-Host Interactions Study Section [BHI]


ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Chronic Kidney Disease (CKD) affects 15% of the adult population in the United States and half of these patients die from cardiovascular disease, with the primary cause related to cardiac fibrosis (left ventricular hypertrophy) and arrhythmias. Diets are widely used as an effort to prevent heart disease in patients with and without CKD, but there are only limited studies in CKD. In the current proposal, we will test a simple dietary intervention of fiber to change the gut bacteria and reduce a toxin that accumulates in kidney disease and determine how that affects the hear in order to prevent cardiovascular disease.

PI_NAMEs: MOE, SHARON M (contact)

PROGRAM_OFFICER_NAME: SOPKO, GEORGE

PROJECT_TERMS: Adenine;Adult;Affect;Age;Anemia;Animal Model;Animals;ARNT gene;Arrhythmia;Aryl Hydrocarbon Receptor;aryl hydrocarbon receptor ligand;Binding Proteins;Biological Markers;Blood;calcification;Cardiac;Cardiac Myocytes;Cardiovascular Diseases;cardiovascular effects;cardiovascular risk factor;Cardiovascular system;Cause of Death;Cellulose;Cessation of life;Chronic Kidney Failure;Clinical;Cohort Studies;Connexin 43;Connexins;Coronary Arteriosclerosis;coronary fibrosis;CYP1B1 gene;Data;design;Diagnostic;Dialysis patients;Dialysis procedure;Diet;dietary;Dietary Intervention;Drug Metabolic Detoxication;EFRAC;Electrocardiogram;Excretory function;FGFR4 gene;Fiber;fibroblast growth factor 23;Fibroblasts;Fibrosis;Functional disorder;Gene Expression;Genes;gut bacteria;gut microbiome;gut microbiota;Hearing;Heart;heart disease prevention;Heart failure;heart function;Human;Hypertension;Hypertrophy;improved;in vivo;indexing;Indican;Individual;Inflammation;inorganic phosphate;Inulin;Kidney;Kidney Diseases;Laboratories;Lead;Left Ventricular Hypertrophy;Left Ventricular Mass;MAP Kinase Gene;Maps;Measures;Mediating;Meta-Analysis;Modeling;Molecular Weight;mortality;mouse model;Mus;Myofibroblast;nuclear factors of activated T-cells;Optics;Outcome;Oxidative Stress;Pathology;Patients;Phenotype;Phosphorus;Population;preservation;prevent;primary outcome;Probenecid;protein expression;PTH gene;Rattus;receptor;Regulation;Renal dialysis;Risk;Risk Factors;Rodent;senescence;Signal Pathway;Signal Transduction;solute;Structure;sudden cardiac death;Testing;Toxin;United States;Uremia;Vascular calcification

PROJECT_TITLE: Uremic Toxins and Cardiovascular Disease


NIH_SPENDING_CATS: Biotechnology;Cancer;Natural Products;Prevention;Prostate Cancer;Urologic Diseases

ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

ORG_STATE: CA

PHR: Project Narrative This study will screen for novel natural products targeting Skp2 degradation for interception of progression in early-stage prostate cancer. In addition, the study will measure Skp2 levels in a large cohort of prostate cancer patient population, allowing identification of patients who most likely respond to a novel clinical trial of Skp2 degraders in the future.

PI_NAMEs: ZI, XIAOLIN  (contact)

PROGRAM_OFFICER_NAME: MOHAMMED, ALTAF

PROJECT_TERMS: active method;advanced disease;American;androgen deprivation therapy;base;Biological Assay;Bladder;Cancer Patient;carcinogenesis;Carcinoma;Cell Culture Techniques;Cell Line;Cell model;Cell Survival;Cells;Cessation of life;Chemopreventive Agent;Chimeric Proteins;Clinical;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;Collaborations;cost;CUL1 gene;Cycloheximide;Data;Degradation Pathway;Development;Diet;Dietary Administration;Disease;Disease Progression;Dose;Drug Targeting;DU145;E2F transcription factors;Exhibits;experience;F Box Domain;Family member;Future;Genes;Growth;high throughput screening;Human;Immunohistochemistry;in vivo;inhibitor;Knock-in;Knock-in Mouse;Letters;Libraries;Luciferases;Lung;Lytic;Malignant neoplasm of prostate;Malignant Neoplasms;Measures;men;Messenger RNA;Modeling;Molecular Target;mortality;mouse model;multiplex detection;nano;National Center for Advancing Translational Sciences;Natural Products;new technology;novel;Oncogenes;Organoids;overexpression;patient derived xenograft model;patient population;patient subsets;Patients;PC3 cell line;Pharmaceutical Preparations;predictive marker;premalignant;Prevalence;prevent;Preventive;Primary Neoplasm;Property;Prostate;prostate cancer cell;prostate cancer cell line;prostate cancer prevention;prostate cancer progression;prostate carcinogenesis;Prostatic Intraepithelial Neoplasias;Protac;protein degradation;protein protein interaction;Proteins;prototype;PTEN gene;Quality of life;Radiation;Radiation therapy;Radical Prostatectomy;Reporter;Resources;response;Retinoblastoma Protein;Role;Sampling;Sarcoma;screening;side effect;Skp2 Proteins;Specimen;success;System;targeted agent;Testing;Tissue Microarray;Tissues;tool;Toxic effect;TP53 gene;tumor;Tumor Suppressor Proteins;Tumor Tissue;tumorigenesis;ubiquitin-protein ligase;Validation;Western Blotting

PROJECT_TITLE: Nautral products for targeting Skp2 in cancer interception

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-P (J1)]


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Lung;Rare Diseases;Regenerative Medicine

ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: NARRATIVE Acute Respiratory Distress Syndrome (ARDS) is characterized by injury to endothelial cells, leading to vascular leakage and pulmonary edema, often associated with critical illnesses like sepsis, trauma, and severe COVID-19. With the lack of effective treatments for ARDS, innovative strategies targeting endothelial regeneration and vascular repair are urgently needed. This study aims to investigate the role and mechanisms of perivascular macrophages in regulating endothelial regeneration and vascular repair following acute lung injury, aiming to identify novel therapeutic targets for treating ARDS and addressing the critical need for effective interventions in this life-threatening condition.

PI_NAMEs: ZHOU, BISHENG  (contact)

PROGRAM_OFFICER_NAME: SUTLIFF, ROY L

PROJECT_TERMS: Acute;Acute Lung Injury;Acute Respiratory Distress Syndrome;Address;Adoptive Transfer;Automobile Driving;Biology;blood damage;Blood Vessels;CD44 Antigens;Cell Communication;Cell Proliferation;cell regeneration;cofactor;Communication;Critical Illness;Data;DNA;effective intervention;effective therapy;Endothelial Cells;endothelial regeneration;endothelial repair;Endothelium;Enzymes;Epigenetic Process;epigenetic regulation;exosome;Extravasation;gain of function;Genetic;genetic approach;Glutaminase;Glutamine;histone methylation;Homeostasis;Imaging technology;Immune response;Immunology;improved;in vivo;Inflammatory;Injury;innovation;interstitial;intravital microscopy;Life;Location;loss of function;Lung;lung injury;lung vascular injury;lymphatic vessel;Macrophage;Mediating;Metabolism;microscopic imaging;Modeling;Modification;mouse model;Mus;Natural regeneration;Nature;new therapeutic target;novel therapeutic intervention;Organ;Outcome;pharmacologic;Play;Pneumonia;Positioning Attribute;Process;Production;Publications;Pulmonary Edema;pulmonary function;Recovery;regeneration potential;regenerative;Regenerative capacity;Rejuvenation;repaired;Reporter;Research;Resolution;Role;Sepsis;severe COVID-19;Surface;Techniques;Testing;Therapeutic;Time;tissue regeneration;tissue repair;Tissues;Transgenic Mice;Trauma;Vascularization

PROJECT_TITLE: Perivascular macrophages - a new player in regulating endothelial repair following lung vascular injury

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Down Syndrome;Hearing Loss;Infectious Diseases;Intellectual and Developmental Disabilities (IDD);Neurodegenerative;Neurosciences;Otitis Media;Pediatric

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE. Individuals with Down syndrome, the genetic condition caused by trisomy 21, display widespread auditory dysfunction, with current estimates indicating that ~80% of this population may have one or more forms of hearing loss. However, the mechanisms by which trisomy 21 causes hearing loss are unknown. This project will fund a multi-disciplinary team of synergistic expertise that will employ a combination of human research and research in mouse models of Down syndrome to elucidate how trisomy 21 impairs auditory function.

PI_NAMEs: ESPINOSA, JOAQUIN M. (contact);MERCHANT, GABRIELLE RYAN;STEYGER, PETER STEPHEN

PROGRAM_OFFICER_NAME: KING, KELLY ANNE

PROJECT_TERMS: Acoustics;Address;Affect;Air;Area;Auditory;Auditory Brainstem Responses;Auditory system;Autoimmune Inner Ear disease;Automobile Driving;Behavioral;Biological Assay;Biological Process;biosignature;Blood specimen;Bone Conduction;boys;Cell Physiology;Cells;Chromosome 21;Cochlea;Cognition;cohort;Cohort Studies;Data;Data Set;Development;diagnostic criteria;Dimensions;Down's Syndrome;ear infection;early onset;Etiology;Event;Funding;Genes;Genetic Diseases;Genomic Segment;Health;Hearing;hearing impairment;hearing loss phenotype;Hearing problem;Hearing Tests;hormonal signals;Hospitals;Human;Human Chromosomes;Human Development;IGF1 gene;imaging study;Immune;Impairment;improved;Individual;Inflammatory;insight;Interdisciplinary Study;Interferons;Intervention;Investigation;Knowledge;Kynurenine;Learning;Measurement;Medicine;member;Metabolic;metabolome;microbiome;Mixed Conductive-Sensorineural Hearing Loss;Molecular;Monitor;mouse model;multidisciplinary;Mus;nasopharyngeal swab;Nerve Degeneration;neurodevelopment;neuroinflammation;novel;novel strategies;Otitis Media;otoacoustic emission;ototoxicity;Participant;Pathway interactions;Peripheral;Personal Satisfaction;Pharmaceutical Preparations;pharmacologic;Phenotype;Physiological;Population;pre-clinical;Presbycusis;Process;Production;Proteome;Quality of life;Recording of previous events;Recurrence;Research;Role;Screening procedure;Signal Transduction;Site;social integration;Somatotropin;Speech Development;Structural defect;Testing;transcriptome;transcriptomics;Tympanometry;Universities;Variant;Vestibular dysfunction;Vestibular function;Vestibular Function Tests

PROJECT_TITLE: Multidimensional investigation of auditory dysfunction in Down syndrome


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Complementary and Integrative Health;Dementia;Estrogen;Neurodegenerative;Neurosciences;Prevention;Women's Health Research

ORG_CITY: AUGUSTA

ORG_DEPT: NEUROSURGERY

ORG_NAME: AUGUSTA UNIVERSITY

ORG_STATE: GA

PHR: Two-thirds of approximately 5 million Americans living with Alzheimer's disease (AD) are women, and a higher incidence of AD has been observed in postmenopausal women with lower serum 17β-estradiol (E2) levels. Additionally, patients with aromatase/estrogen inhibition often experience a greater amount of cognitive decline. Therefore, this proposal meets the critical needs as it will examine the underlying mechanisms and evaluate the therapeutic efficacy of non-invasive pulsed laser therapy for the treatment of cognitive deficits following the down-regulation and/or inhibition of brain aromatase.

PI_NAMEs: DHANDAPANI, KRISHNAN M. (contact)

PROGRAM_OFFICER_NAME: CHAKROBORTY, SHREAYA

PROJECT_TERMS: 3xTg-AD mouse;Acceleration;Address;Adjuvant Therapy;adverse outcome;Affect;Aging;Alternative Therapies;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;American;Animal Model;Aromatase;Aromatase Inhibition;Aromatase Inhibitors;Brain;Brain region;Brain-Derived Neurotrophic Factor;burden of illness;Cell Line;Cell Physiology;Characteristics;Clinical;Cognitive;Cognitive deficits;cognitive function;curative treatments;cytochrome c oxidase;Cytochrome P450;Cytochromes;Data;Dementia;Development;Disease;Disease Progression;Disproportionately impacts women;Down-Regulation;Enzymes;epidemiology study;Estradiol;Estrogen Receptors;Estrogens;experience;Exposure to;Female;Functional disorder;functional improvement;gender difference;global health;Heme;Heme Iron;High Prevalence;Homeostasis;Impaired cognition;improved;In Vitro;in vivo;Incidence;inhibitor;innovation;knock-down;Knockout Mice;Lasers;Long-Term Effects;Low-Level Laser Therapy;Mediating;Mediator;Modeling;Molecular Target;Mus;Neurodegenerative Disorders;Neurons;neuroprotection;novel;Pathogenesis;Patients;photobiomodulation;Photons;Physiologic pulse;Play;Postmenopause;preservation;prevent;Prevention;Prevention strategy;Preventive therapy;Production;Prosencephalon;Rattus;Research;Rodent;Rodent Model;Role;Serum;sex;Sex Differences;sexual dimorphism;Signal Pathway;Signal Transduction;Symptoms;Synaptic plasticity;synaptogenesis;targeted treatment;Testing;Testosterone;transgenic model of alzheimer disease;Transgenic Organisms;Treatment Efficacy;United States;Vertebral column;Woman;Women's prevalence

PROJECT_TITLE: Role of Brain Aromatase in Alzheimer's Dementia: Sex differences and the Preventive Therapy using Pulsed Photobiomodulation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 AN-Q (55)]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Digestive Diseases;Genetics;Liver Cancer;Liver Disease;Precision Medicine;Rare Diseases

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

PHR: PROJECT NARRATIVE: Hepatocellular carcinoma (HCC), or primary liver cancer, results in considerable worldwide illness and fatality, especially when it grows beyond the original location and spreads within the liver. Advances in HCC diagnostics and treatment are highly dependent on the development of new systems to better understand cancer growth. The aim of this research study is to utilize a pig HCC model to investigate the ability of advanced imaging techniques to noninvasively provide insights into HCC tumor biology, with the overall goal of incorporating these techniques into clinical management to improve diagnosis, treatment, and treatment response monitoring for liver cancer patients.

PI_NAMEs: CAI, KEJIA  (contact);GABA, RON C

PROGRAM_OFFICER_NAME: TANDON, PUSHPA

PROJECT_TERMS: Ablation;Address;Area;Biochemical;Biopsy;Blood Vessels;Cancer Etiology;Cancer Model;Cells;Cessation of life;Characteristics;Chemicals;Clinical;Clinical Management;clinical practice;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;Collection;Creatine;Curative Surgery;Cytosol;Development;Diagnosis;Diagnostic;diagnostic biomarker;diagnostic tool;Diffusion;effective therapy;empowerment;Engineering;Evaluation;Excision;Family suidae;Funding;Gene Targeting;Genes;Genetic Heterogeneity;genetic profiling;Goals;Grant;Growth;Heterogeneity;Human;Image;Imaging Techniques;improved;In Vitro;in vivo;innovation;insight;intrahepatic;Invaded;Kinetics;knock-down;Knock-out;Knowledge;KRASG12D;Liver;liver cancer model;liver cancer patient;Location;Magnetic Resonance Imaging;Malignant - descriptor;Malignant neoplasm of liver;Malignant Neoplasms;Maps;Measurement;Metabolic;Metabolism;migration;mitochondrial creatine kinase;Molecular;Molecular Profiling;Monitor;Morphologic artifacts;Motion;mRNA Differential Displays;multidisciplinary;Natural regeneration;Nodule;non-invasive imaging;Oncopig;overexpression;patient prognosis;Patient-Focused Outcomes;Patients;Pattern;Performance;Phosphocreatine;Population;porcine model;Primary carcinoma of the liver cells;Primary Malignant Neoplasm of Liver;Prognosis;prognostic tool;Proliferating;Protocols documentation;Radiofrequency Interstitial Ablation;Recurrence;research study;Resolution;Respiration;respiratory;Risk Assessment;risk stratification;Sensitivity and Specificity;Serum;Survival Rate;System;Techniques;Testing;Therapeutic;Transgenic Organisms;treatment response;treatment stratification;tumor;Tumor Biology;Tumor Burden;tumor growth;tumor heterogeneity;tumor metabolism;tumor progression

PROJECT_TITLE: Noninvasive High-Resolution Mapping of HCC Tumor Biology Predictive of Malignancy

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]