ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Prevention

ORG_CITY: MINNEAPOLIS

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF MINNESOTA

PHR: NARRATIVE The proposed research is relevant to public health because it focuses on the maintenance and transmission of Shiga toxin-producing Escherichia coli (STEC), a potentially devastating foodborne pathogen. The focus on how STEC infect humans is aligned with NIAID’s E. coli priority area. Characterizing local STEC transmission systems will facilitate the development of targeted disease control interventions, with the ultimate goal of mitigating the burden of STEC in our population.

PI_NAMEs: TARR, GILLIAN  (contact)

PROGRAM_OFFICER_NAME: BAQAR, SHAHIDA

PROJECT_TERMS: Accounting;Age;age difference;Animals;Area;Bioinformatics;Canada;Case Mixes;Case Study;Cattle;Characteristics;Child;Classification;Collaborations;Data;Deer;density;design;Detection;Development;Disease;Disease Outbreaks;disorder control;disorder risk;Environment;Environmental Pollution;epidemiological model;Epidemiology;Escherichia coli;Escherichia coli EHEC;Escherichia coli Infections;Escherichia coli O157:H7;Exposure to;Farm;Food;food desert;Food production;Food Safety;Food Supply;foodborne pathogen;Future;Genes;Genomics;Genotype;Goals;Health;Human;Infection;innovation;insight;Intervention;Investigation;Knowledge;Linear Models;Location;Maintenance;Mentorship;Meta-Analysis;Mexico;migration;Milk;Minnesota;Modeling;National Institute of Allergy and Infectious Disease;Outcome;pathogen;Pathway interactions;Persons;Phylogenetic Analysis;Phylogeny;Physical environment;Population;Population Density;population migration;Population Sizes;Production;Proxy;Public Health;public health intervention;Recording of previous events;Reporting;Research;Risk;Risk Factors;Route;Ruminants;rural environment;segregation;sex;Sheep;Shiga Toxin;skills;Social Environment;Source;source localization;stem;Structure;System;Testing;Training;transmission process;Travel;Trees;Universities;Virulence Factors;Visit;Water;Weather;Work

PROJECT_TITLE: Phylodynamics of Shiga Toxin-Producing Escherichia coli from Local Sources

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases B Research Study Section[MID-B]


ADMINISTERING_IC: AI

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: IRVINE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

ORG_STATE: CA

PHR: Project narrative: Antibody secretion by B cells is a major component of our immune response and mis-regulated antibody response underlies many auto-immune diseases. In this proposal, we will characterize the post-transcriptional gene regulation in B cells to understand how antibody secretion is regulated.

PI_NAMEs: SCIAMMAS, ROGER ;SHI, YONGSHENG  (contact)

PROGRAM_OFFICER_NAME: CASTLEMAN, MORIAH JOVITA

PROJECT_TERMS: Alleles;Alternative Splicing;Antibodies;Antibody Response;Autoimmune Diseases;B-Cell Activation;B-Cell Development;B-Lymphocytes;Binding;Biochemical;Biological Process;cell mediated immune response;Cell Physiology;Cells;Complex;CRISPR screen;Data;design;Development;Disease;Gene Expression Regulation;gene network;Genes;genetic approach;genome-wide;Immune response;Immunoglobulin M;Individual;insight;Link;Malignant Neoplasms;Membrane;Messenger RNA;Modeling;Neurodegenerative Disorders;novel;Pattern;Play;Polyadenylation;Post-Transcriptional Regulation;Process;Protein Isoforms;Proteins;Regulation;Reporter;Reporting;RNA Processing;RNA-Binding Proteins;Role;Signaling Protein;Testing;Transcript;transcription factor;Transcriptional Activation;Transcriptional Regulation;vaccine development;Work

PROJECT_TITLE: mRNA alternative polyadenylation in B cell development

STUDY_SECTION: CMIA

STUDY_SECTION_NAME: Cellular and Molecular Immunology - A Study Section[CMIA]


NIH_SPENDING_CATS: Anthrax;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases;Rare Diseases

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: NARRATIVE Results from these studies will yield mechanistic insight into newly discovered stress sensing systems involved in the adaptive response of microbial pathogens to antimicrobial molecules within the host. The conservation of these systems in the organisms that cause staph infections, listeriosis, anthrax, and enterococcal infections enable our results to be extrapolated to multiple human pathogens and may lead to the development of new therapeutics for the treatment of infectious diseases.

PI_NAMEs: SKAAR, ERIC P (contact)

PROGRAM_OFFICER_NAME: HUNTLEY, CLAYTON C

PROJECT_TERMS: Affect;Anthrax disease;antimicrobial;Antimicrobial Resistance;Bacillus anthracis;Bacteria;Binding;Biochemical;biological adaptation to stress;Bioterrorism;Cardiolipins;Catalogs;cell envelope;coping;Data;Detection;Development;Drug Metabolic Detoxication;Enabling Factors;Enterococcus;Environment;Enzymes;Event;experimental study;Family member;Gene Expression;Genes;Genetic;genetic regulatory protein;genetic selection;Genetic Transcription;Gram-Positive Bacteria;Growth;Heme;human pathogen;Infection;infectious disease treatment;innovation;insight;Integration Host Factors;Kinetics;Life Cycle Stages;Listeriosis;Location;Macrophage;Mediating;member;Membrane;microbial;Microbiology;Modeling;mRNA Stability;mRNA Transcript Degradation;Names;National Security;new therapeutic target;novel therapeutics;Organism;pathogen;Pathogenesis;pathogenic bacteria;pathogenic microbe;Pathogenicity;Phagocytes;Phagocytosis;posttranscriptional;Process;Production;Proteins;Public Health;Regulation;Regulon;Resistance;resistant strain;response;RNA;RNA Stability;RNA-Binding Proteins;Role;Series;Signal Transduction;Staphylococcal Infections;Staphylococcus aureus;Stimulus;Stress;stressor;System;Systemic infection;Testing;Toxic effect;Transcript;transcription factor;Translating;Vertebrates

PROJECT_TITLE: Pathobiology of heme inducible transporters in Gram positive pathogens

STUDY_SECTION: BACP

STUDY_SECTION_NAME: Bacterial Pathogenesis Study Section[BACP]


ORG_CITY: SAINT LOUIS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative HIV-1 infection is not curable by antiretroviral therapy due to the presence of latent viral reservoirs. To develop novel strategies for the viral reservoir eradication, we aim to study the role of CARD8 inflammasome in HIV-1 infection and develop strategies to induce CARD8 activation to eliminate latent HIV-1 reservoirs.

PI_NAMEs: SHAN, LIANG  (contact)

PROGRAM_OFFICER_NAME: SHANKAR, UDAY K

PROJECT_TERMS: Adaptive Immune System;Amino Acid Sequence;Antibodies;antiretroviral therapy;Apoptotic;Binding;Biological Assay;Blood;C-terminal;CASP1 gene;CD28 gene;CD3 Antigens;CD4 Positive T Lymphocytes;Cell Death;Cell Line;Cells;Chemicals;clinical subtypes;Combined Modality Therapy;Complex;cytokine;Dimerization;DNA;Early treatment;efavirenz;Epitopes;Evaluation;Frequencies;Gene Expression;Genome;Grant;high throughput screening;HIV;HIV Protease;HIV-1;HIV-1 protease;Human;humanized mouse;Immune;immune clearance;Immune system;In Vitro;in vivo;Individual;Infection;Inflammasome;Inflammation;Interleukin-1 beta;Interruption;Investigation;Knock-in Mouse;latent HIV reservoir;Libraries;Ligands;Macrophage;Measures;Mediating;memory CD4 T lymphocyte;microbial;Molecular;Molecular Conformation;mouse model;Mus;Mutation;N-terminal;Names;NNRTI-resistance;non-nucleoside reverse transcriptase inhibitors;novel strategies;Patients;Pattern recognition receptor;Peptide Hydrolases;Pharmaceutical Preparations;Physiological;Plasma;pol Gene Products;Predisposition;premature;prevent;protein function;Protein Precursors;Proteins;Regimen;Reporter;Research;Resistance;resistance mutation;response;Rest;RNA;Role;screening;Shock;Signal Transduction;T-Lymphocyte;Testing;Time;Tissues;Variant;Viral;Viral Cytopathogenic Effect;Viral Genes;Viral Proteins;viral rebound;Viral reservoir;viral RNA;Virus;Virus Activation;Virus Latency

PROJECT_TITLE: Understand the role of CARD8 inflammasome in HIV-1 infection

STUDY_SECTION: HVCD

STUDY_SECTION_NAME: HIV Molecular Virology, Cell Biology, and Drug Development Study Section[HVCD]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: NEWARK

ORG_DEPT: PSYCHOLOGY

ORG_NAME: RUTGERS THE STATE UNIV OF NJ NEWARK

ORG_STATE: NJ

PHR: NARRATIVE The proposed G-RISE Program aims to increase the number of pre-doctoral trainees traditionally underrepresented in the diverse fields of Biology, Chemistry, Neuroscience and Psychology. The program will foster promising careers of trainees on a trajectory to enter the behavioral/biomedical research workforce, by providing them with the training resources and mentoring support to assist them in earning a PhD, competing for fellowships and proceeding to a postdoctoral research position.

PI_NAMEs: DELGADO, MAURICIO R.;KOMISARUK, BARRY RICHARD (contact)

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TERMS: Research Training;Students;Universities

PROJECT_TITLE: Graduate Research Training Initiative for Student Enhancement (G-RISE) (T32) at Rutgers University-Newark

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - D[TWD-D]


ADMINISTERING_IC: DA

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Assistive Technology;Behavioral and Social Science;Bioengineering;Clinical Research;Drug Abuse (NIDA only);Harm Reduction for Substance Misuse;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Opioid Misuse and Addiction;Opioids;Patient Safety;Prevention;Substance Misuse

ORG_CITY: SEATTLE

ORG_NAME: AYUDA MEDICAL

ORG_STATE: WA

PHR: 2021 09, Hite, Naloxone Parachute: Novel Wearable Dual Sensor Regional Oximeter to Detect Opioid-Induced Hypoxia and Enable Emergent Naloxone Rescue NARRATIVE: We are developing a wearable Opioid Overdose (OOD) Diagnostic device, that will decrease the time from OOD to recognition by bystanders, and therefore decrease time to resuscitation (and possible naloxone administration), with a goal to reduce the fatality rate of OOD in the ambulatory setting. A discreet biosensor device that detects life-threatening OOD with on-device logic and alarms locally, without wireless connectivity needed, is a fundamental improvement in patient safety because it removes all risk of connectivity (e.g. wearable device to mobile-device of User, and then to cloud for data analysis and response, introduces many opportunities for error), and enables patients to be rescued in a variety of circumstances where wireless connection may not be present to transmit the acute event (basement, car, etc). The addition of an adjunct (not required for device function) wireless alert, to people who have been specifically selected by the device User, adds an additional opportunity for intervention in OOD, giving agency to loved ones to act in case of an emergency (they may be nearby, or can call 911) - expanding the opportunities for intervention improves the likelihood of preventing fatal OOD.

PI_NAMEs: HITE, DESISLAVA ZLATANOVA (contact)

PROGRAM_OFFICER_NAME: ANGELONE, LEONARDO MARIA

PROJECT_TERMS: 911 call;Accidents;Acute;Adverse effects;Algorithms;arm;Biosensor;Blood gas;Bluetooth;Body Weight;Breakthrough device;Cardiopulmonary Resuscitation;Certification;Charge;Chronic;chronic pain;Clinical;clinical diagnostics;Clinical Research;cloud based;Collaborations;commercialization;Communication;communication device;Communities;Data;Data Analyses;data exchange;Dedications;design;Development;Device Designs;Device or Instrument Development;Device Safety;Devices;Diagnostic Equipment;Distress;Drops;Early Diagnosis;Effectiveness;Emergency Situation;Engineering;Enrollment;Environment;Environmental Monitoring;Evaluation;Event;Exanthema;Fatality rate;Feasibility Studies;Formularies;Gases;Goals;handheld mobile device;Hearing;Home;Hour;Human;Hypoxia;impression;improved;Ingestion;Innovation Corps;Instruction;Intervention;Intravenous;Intuition;Label;Learning;Life;Light;Location;Logic;Longevity;loved ones;Low Income Population;Marketing;Measures;Mediating;Medicaid;Medical;Medical emergency;mobile application;mobile medical application;Monitor;Motion;Naloxone;National Institute of Drug Abuse;Neighborhood Health Center;novel;Opioid;opioid overdose;opioid use;opioid use disorder;opioid user;Output;Parachuting;patient safety;Patients;Performance;Persons;Phase;Physiologic Monitoring;Physiologic pulse;Physiological;Pilot Projects;Population;Populations at Risk;pressure;prevent;Probability;Protocols documentation;Recording of previous events;remifentanil;Reporting;Research Design;Research Personnel;Resolution;Respiration;response;Resuscitation;Risk;Safety;sensor;side effect;Signal Transduction;Sleep;Small Business Innovation Research Grant;Speed;standard of care;stressor;success;Sunlight;System;Target Populations;Telephone;Testing;Time;Tourniquets;transmission process;United States Food and Drug Administration;United States Substance Abuse and Mental Health Services Administration;Upper arm;verbal;Vision;Voice;wearable device;wireless

PROJECT_TITLE: A Naloxone Parachute: Novel Wearable Dual-Sensor Regional Oximeter to Detect Opioid-Induced Hypoxia and Enable Emergent Naloxone Rescue


ORG_CITY: DURHAM

ORG_DEPT: GENETICS

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: NARRATIVE  The first goal of this proposal is to define mechanisms of unisexual reproduction of the human fungal pathogen Cryptococcus and how this reproductive mode controls population structure and diversity, production of infectious spores, and pathogenesis. The second goal is to elucidate how the RNAi pathway, which we discovered is activated during sexual reproduction, silences transposons and repetitive genes, and the consequences of RNAi loss in hypermutator strains and outbreak species with regard to genome stability, emergence of drug resistance, and pathogenicity. The Cryptococcus pathogenic species complex encompasses ~10 eukaryotic species that have a significant impact on global public health and afflict both immunocompetent and immunocompromised patients causing life-threatening infections of the lungs and brain (pneumonia, meningoencephalitis); together these species are responsible for >220,000 infections each year, and more than 181,000 deaths worldwide resulting in >15% of all HIV/AIDS-associated deaths.

PI_NAMEs: HEITMAN, JOSEPH  (contact)

PROGRAM_OFFICER_NAME: LOVE, DONA

PROJECT_TERMS: Acceleration;Affect;Aneuploidy;Animal Model;Animals;Attenuated;Automobile Driving;Award;Brain;Cessation of life;Characteristics;Clinical;Clonality;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;Cryptococcus;Cryptococcus gattii;Cryptococcus neoformans;Detection;Development;Disease Outbreaks;DNA;DNA Sequence;Drug resistance;drug resistance development;Engineering;Environmental Risk Factor;Epidemiology;Evolution;Exclusion;fitness;Frequencies;Funding;Gene Expression Profile;Gene Silencing;Generations;Genes;Genetic;Genetic Variation;Genome;genome integrity;Genome Stability;Goals;HIV/AIDS;Human;human pathogen;Immunocompetent;Immunocompromised Host;In Vitro;Individual;Infection;infectious disease evolution;insight;Introns;Laboratories;Life;Life Cycle Stages;Longitudinal Studies;low income country;Lung infections;Maintenance;Mating Types;Mediating;Meiosis;Meningoencephalitis;microbial;Mitosis;Mitotic;Modeling;Morbidity - disease rate;mortality;Movement;mutant;Mutation;Mycoses;new outbreak;Nonsense Mutation;novel;Nutrient;Outcome Study;Pacific Northwest;Partner in relationship;pathogen;Pathogenesis;pathogenic fungus;pathogenic microbe;Pathogenicity;Pathway interactions;Patients;Pattern;Plants;Ploidies;Pneumonia;Population;Population Control;Positioning Attribute;Prevention;Production;Proteins;Public Health;Repetitive Sequence;Reproduction;Reproduction spores;reproductive;RNA;RNA Interference;RNA Splicing;Role;sensor;Serotyping;sex;Sexual Reproduction;Spliceosomes;Structure;success;Testing;Transgenes;Virulence;Zinc Fingers

PROJECT_TITLE: Impact of RNAi and unisexual reproduction on Cryptococcus evolution, drug resistance, and pathogenesis

STUDY_SECTION: PTHE

STUDY_SECTION_NAME: Pathogenic Eukaryotes Study Section[PTHE]


ORG_CITY: STANFORD

ORG_DEPT: BIOPHYSICS

ORG_NAME: STANFORD UNIVERSITY

PHR: This proposal seeks to understand the mechanisms that control calcium entry through store-operated calcium channels (SOCs), a unique type of ion channel present in nearly every cell in the body. Mutations that inhibit SOCs lead to multiple disorders in humans, most notably a lethal combined immunodeficiency syndrome that underscores the essential role of store-operated calcium entry for immunity and survival. The proposed studies will contribute to a fundamental understanding of the intricate pathways that regulate these channels and processes they control, and may also reveal new targets for drug development, with the goal of enhancing function in individuals with compromised immunity, or inhibiting immunity to treat autoimmune disease or prevent organ transplant rejection.

PI_NAMEs: LEWIS, RICHARD S (contact)

PROGRAM_OFFICER_NAME: CHAO, CHIEN-CHUNG

PROJECT_TERMS: Appearance;Autoimmune Diseases;Binding;Biological Assay;Calcium;Calcium Channel;Calcium Signaling;Cell membrane;Cell Physiology;Cells;Complex;cost;crosslink;Diffusion;Disease;drug development;Excision;Fluorescence;gain of function;Goals;Human;human disease;immune activation;Immunity;Immunologic Deficiency Syndromes;Individual;Ion Channel;Laboratories;Lead;Location;loss of function mutation;Molecular;Molecular Conformation;Monitor;Motility;Muscle;Mutation;new therapeutic target;organ transplant rejection;Pathway interactions;Physiological Processes;Positioning Attribute;prevent;Process;Property;Proteins;receptor;Regulation;Role;Signal Transduction;single molecule;Site;STIM1 gene;stoichiometry;Techniques

PROJECT_TITLE: Molecular and cellular mechanisms of store-operated calcium channels

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Bioengineering;Brain Disorders;Childhood Injury;Clinical Research;Disability Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Pediatric;Prevention;Rehabilitation

ORG_CITY: PHILADELPHIA

ORG_DEPT: PHYSICAL MEDICINE & REHAB

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: NARRATIVE Increased survival rates of medically fragile infants lead to an increased number of children with functional impairments later in life. Early detection of motor delays or impairments provides the opportunity for early treatment which improves health outcomes. This study will use state of the art sensors combined with machine learning approaches to develop objective, accurate, easy-to-use tools for the early scoring of deficits and lays the foundation for the early prediction of physical disability.

PI_NAMEs: JOHNSON, MICHELLE J. (contact);KORDING, KONRAD P.

PROGRAM_OFFICER_NAME: NITKIN, RALPH M

PROJECT_TERMS: Age Months;Algorithms;Asphyxia;automated assessment;Back;Behavior;Birth History;Brain Injuries;Calibration;Child;Childhood;Classification;Clinical;Collaborations;Complex;Computer Vision Systems;Consumption;critical period;Cross-Sectional Studies;Data;Data Analyses;design;Development;Developmental Delay Disorders;Diagnosis;diagnostic platform;diagnostic tool;disability;disability risk;drug use in pregnancy;Early Diagnosis;Early identification;early screening;Early treatment;Educational Status;Effectiveness;Foundations;Functional impairment;functional outcomes;Future;Generations;Goals;Hand Strength;Health;health assessment;Hydrocephalus;Impairment;improved;Infant;Infant Development;Infant Health;infant monitoring;Infection;instrument;Intervention;Intuition;kinematics;Knowledge;large datasets;Lead;Life;Limb structure;Long term physical disability;Longitudinal Studies;Machine Learning;machine learning algorithm;Measures;Medical;Monitor;Motor;motor control;Motor disability;motor impairment;Movement;multimodality;neonatal stroke;neurodevelopment;Neurodevelopmental Disability;Neurologic;Neuronal Plasticity;novel strategies;Outcome;Pediatrics;Performance;physically handicapped;Pilot Projects;Play;Population;Posture;Predictive Value;Premature Birth;pressure;prognostic tool;Recommendation;recruit;Risk;School-Age Population;screening;Seizures;sensor;sensor technology;skeletal;Supination;Survival Rate;System;Techniques;Testing;Time;tool;Toy;Training;Translating;United States National Institutes of Health;vector;Video Recording;Work

PROJECT_TITLE: Automated Assessment of Neurodevelopment in Infants at Risk for Motor Disability

STUDY_SECTION: MFSR

STUDY_SECTION_NAME: Motor Function, Speech and Rehabilitation Study Section[MFSR]


ADMINISTERING_IC: AG

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE The mammalian genome is arranged around large, nuclear compartments, and this genome organization provides an important layer of gene regulation. In tauopathies, nuclear speckles, which are membraneless compartments enriched in splicing factors, are perturbed, leading to defects in splicing. This work will identify chromatin in proximity to nuclear speckles in mature neurons as well as neurons with tau aggregates, which will improve understanding of gene expression and splicing defects that occur in tauopathies.

PI_NAMEs: COLE, MITCHEL ALFONZA (contact)

PROGRAM_OFFICER_NAME: SARE, RACHEL

PROJECT_TERMS: 3-Dimensional;Acute;Adult;Aging;Alzheimer's Disease;Alzheimer's disease risk;Animal Model;Architecture;Bioinformatics;Biology;Brain;career;Career Choice;Cell Physiology;Cell Separation;Cells;Chromatin;Cleavage Under Targets and Release Using Nuclease;Computational Biology;Data;Defect;differential expression;Disease;Epigenetic Process;epigenomics;experience;Foundations;Gene Expression;Gene Expression Regulation;Genes;Genetic Transcription;Genome;Genomic Segment;Genomics;Goals;Heterochromatin;histone modification;Human;human model;human tissue;improved;in vivo;insight;interest;Learning;life span;mammalian genome;Membrane;Messenger RNA;Methods;Microtubules;model organism;Modeling;Molecular Biology;Morphologic artifacts;mouse model;Movement;Mus;Nerve Degeneration;nerve stem cell;Nervous System Disorder;Neurobiology;Neurodegenerative Disorders;Neurologist;Neurology;neuron loss;Neurons;Nuclear;Nuclear Lamina;Nuclear Structure;Pathogenesis;Pathogenicity;Physicians;postmitotic;Proteins;Reporter;Research;risk variant;RNA Splicing;Scientist;skills;Spliced Genes;Structure;Synapses;tau aggregation;tau expression;tau mutation;tau Proteins;Tauopathies;Techniques;Technology;Testing;Tissue-Specific Gene Expression;Training;Transcriptional Regulation;transcriptomics;Variant;Work

PROJECT_TITLE: Genome organization of post-mitotic neurons in maturation and disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F08-M(20)L]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Clinical Research;Immunotherapy;Ovarian Cancer;Precision Medicine;Rare Diseases;Women's Health Research

ORG_CITY: KANSAS CITY

ORG_NAME: CHILDREN'S MERCY HOSP (KANSAS CITY, MO)

PHR: PROJECT NARRATIVE Novel approaches are needed to characterize the tumor immune microenvironment (TIME) to identify novel biology and determine the TIME features that relate to clinical outcomes. Multiplex immunofluorescence (mIF) combined with automated image analysis is a widely used technique which allows for the assessment and visualization of the TIME. In this research, we will develop and test novel statistical methods to analyze mIF data that incorporates the spatial heterogeneity of the TIME, in addition to abundance measures of immune cells, whereby producing freely available software for the research community. The novel methods will be applied to the study of epithelial ovarian cancer (EOC), the deadliest gynecologic malignancy in the U.S., using existing mIF data from ~2,500 diverse EOC patients. An ovarian-specific immunoscore predictive of survival will be developed which can be used in patient stratification efforts to optimize therapeutic efficacy and ultimately, reduce cancer mortality.

PI_NAMEs: FRIDLEY, BROOKE L (contact);PERES, LAUREN COLE

PROGRAM_OFFICER_NAME: MILLER, DAVID J

PROJECT_TERMS: Architecture;automated image analysis;B-Lymphocytes;Bayesian Modeling;Binomial Model;Biological Markers;Biology;biomarker discovery;cancer epidemiology;Cancer Patient;cancer type;cell type;Cells;Clinical;cohort;Communities;Computer software;Cytotoxic T-Lymphocytes;Data;Data Analyses;Derivation procedure;Development;Ensure;epidemiology study;Epithelial ovarian cancer;Goals;Heterogeneity;Immune;immune checkpoint;Immunofluorescence Immunologic;Immunofluorescence Microscopy;Immunophenotyping;improved outcome;interest;Malignant Female Reproductive System Neoplasm;Malignant neoplasm of ovary;Malignant Neoplasms;Measurement;Measures;Methodology;Methods;mortality;Nature;new technology;novel;novel strategies;Outcome;outcome prediction;Ovarian;ovarian neoplasm;participant enrollment;patient stratification;Pattern;Performance;Phenotype;Population;Prognostic Marker;Proteins;Recurrence;Reproducibility;Research;Sampling;segregation;Statistical Methods;survival prediction;T-Lymphocyte;Techniques;Testing;Tissue Microarray;Tissues;tool;Treatment Efficacy;tumor;tumor heterogeneity;Tumor-associated macrophages;tumor-immune system interactions;Tumor-Infiltrating Lymphocytes;Visualization;Woman;Work

PROJECT_TITLE: Spatial and Bayesian modeling methods for assessment of the tumor immune microenvironment and survival of women with ovarian cancer

STUDY_SECTION: ASPA

STUDY_SECTION_NAME: Analytics and Statistics for Population Research Panel A Study Section[ASPA]


ORG_CITY: MANHATTAN

ORG_DEPT: PHYSICS

ORG_NAME: KANSAS STATE UNIVERSITY

ORG_STATE: KS

PHR: Project Narrative Biomolecule condensates are an important feature of cellular function and potential intervention target in cancer and neurodegenerative disease. Preliminary results show that the disordered network of interactions that stabilizes condensates also encode unique functional characteristics. The proposed work will elucidate the structure/function relationships within disordered networks, thereby facilitating the design of targeted interventions.

PI_NAMEs: SCHMIT, JEREMY DAVID (contact)

PROGRAM_OFFICER_NAME: NGUYEN, HAN

PROJECT_TERMS: Adopted;Architecture;Behavior;Binding;Biochemical;Biogenesis;Biological;Biological Models;Cell Nucleolus;Cell Physiology;Cellular Structures;Characteristics;Charge;Client;Cryoelectron Microscopy;Data;design;Disease;driving force;Electrostatics;enthalpy;Entropy;Evolution;experimental study;In Vitro;in vivo;Intervention;kinetic theory;Learning;Length;Link;Liquid substance;Literature;Malignant Neoplasms;Methods;Microscopic;Modeling;Molecular;molecular assembly/self assembly;Molecular Probes;Molecular Structure;Neurodegenerative Disorders;Nuclear;Organelles;Phase;Physical condensation;Polymers;Procedures;Process;Property;Proteins;recruit;Research;Ribosomal RNA;Ribosomes;RNA-Protein Interaction;Roentgen Rays;segregation;Site;structural biology;Structural Models;Structure;Structure-Activity Relationship;System;Techniques;Theoretical model;theories;Therapeutic;tool;Work

PROJECT_TITLE: Structure-function properties in liquid organelles

STUDY_SECTION: MSFD

STUDY_SECTION_NAME: Macromolecular Structure and Function D Study Section[MSFD]


ADMINISTERING_IC: AR

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Back Pain;Chronic Pain;Clinical Research;Genetics;Human Genome;Pain Research;Precision Medicine;Prevention

ORG_CITY: ANN ARBOR

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE Pain after surgery that lasts more than 3 months is termed chronic postsurgical pain (CPSP) and occurs in up to 50% of patients, contributing to an epidemic of chronic pain that has a greater annual societal cost than that of cancer, heart disease, and diabetes combined. It is currently unclear how much of a role genetic variation has on the development of CPSP, and which genetic mutations are significant. The goal of this proposal is to identify genetic factors that predispose patients to develop CPSP and influence the response to pain therapies.

PI_NAMEs: FRANGAKIS, STEPHAN  (contact)

PROGRAM_OFFICER_NAME: WASHABAUGH, CHARLES H

PROJECT_TERMS: Academy;Analgesics;antinociception;Applications Grants;authority;biobank;Biological;Biometry;Bypass;Candidate Disease Gene;care costs;career;career development;Chronic;Chronic low back pain;chronic pain;clinical training;Clinical Trials;Clinical Trials Design;cohort;Collaborations;Complement;Data;Data Set;Development;Diabetes Mellitus;Discipline;DNA Sequence Alteration;duloxetine;Environmental Risk Factor;Epidemic;Epidemiology;experience;feeding;Funding;Future;gene function;Genes;Genetic;genetic analysis;genetic approach;genetic association;genetic information;Genetic Markers;genetic predictors;Genetic Predisposition to Disease;Genetic Research;genetic risk factor;Genetic study;genetic variant;Genetic Variation;Genome;genome wide association study;genome-wide;Genomics;Genotype;Goals;Grouping;Heart Diseases;Hospitalization;Individual;insight;Institution;K-Series Research Career Programs;Lead;Low Back Pain;Malignant Neoplasms;Measures;Medicine;meetings;Mentors;Mentorship;Michigan;Molecular;Morbidity - disease rate;multidisciplinary;neuroimaging;novel;Operative Surgical Procedures;opioid use;Pain;Pain management;pain outcome;pain patient;Participant;Pathway Analysis;Pathway interactions;patient oriented;patient response;Patient Self-Report;patient subsets;Patients;Perioperative;pharmacologic;Phenotype;Physical Function;physical impairment;Physicians;Positioning Attribute;Postoperative Pain;potential biomarker;precision medicine;predicting response;programs;prospective;Quality of life;Recovery;Research;Research Methodology;Resources;response;response biomarker;Role;Sampling;Scientist;Site;societal costs;success;Surveys;systematic review;Testing;Training;Translational Research;treatment response;United States;United States National Institutes of Health;Universities;Variant;Work

PROJECT_TITLE: Genetic Markers of Chronic Postsurgical Pain

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


NIH_SPENDING_CATS: Autoimmune Disease;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Disability Research;Dissemination and Implementation Research;Health Services;Mental Health;Multiple Sclerosis;Neurodegenerative;Neurosciences;Rehabilitation;Telehealth

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: Project Narrative Of the nearly 1 million people in the United States with multiple sclerosis (MS), 80% experience chronic fatigue and two-thirds describe fatigue as their most troubling symptom. While Cognitive Behavioral Therapy (CBT) for fatigue reduces the impact of fatigue on daily activities in people with MS, it is not widely accessed in the private sector. The proposed project seeks to identify the active ingredients of CBT for MS fatigue in order to optimize it for efficacy and efficiency to improve access to an evidence-based intervention and reduce the impact of fatigue on daily functioning in people living with MS.

PI_NAMEs: KNOWLES, LINDSEY MAJOR (contact)

PROJECT_TERMS: acceptability and feasibility;Adult;Affect;Analysis of Variance;Behavior Therapy;Behavioral;behavioral health intervention;Behavioral Model;career;career development;Case Series;Chronic;Clinical Trials;Cognitive;Cognitive Therapy;daily functioning;Data;design;disability;disabling symptom;Disease;Doctor of Philosophy;effective therapy;Emotional;evidence base;Evidence based intervention;Exclusion;experience;Fatigue;Fellowship;follow up assessment;follow-up;Funding;Future;Goals;Health;Healthcare Systems;Hour;implementation barriers;implementation determinants;implementation facilitation;Improve Access;improved;improved outcome;Individual;Intervention;intervention effect;intervention refinement;Intervention Studies;Knowledge;Long COVID;Malignant Neoplasms;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Methods;multiphase optimization strategy;Multiple Sclerosis;multiple sclerosis patient;multiple sclerosis treatment;Observation in research;Outcome;patient engagement;Persons;Physical Medicine;Physiological;pilot test;Population;post intervention;Postdoctoral Fellow;Pre-Post Tests;primary outcome;Private Sector;prospective;Psychologist;psychosocial;Qualitative Research;Quality of life;Randomized;Randomized, Controlled Trials;Reaction;rehabilitation research;Rehabilitation therapy;Relaxation;Relaxation Therapy;Reporting;Research;Research Methodology;Research Personnel;Research Project Grants;Resources;Role;Scientific Advances and Accomplishments;Self Efficacy;skill acquisition;skills;sound;Spinal cord injury;Stress;Stress and Coping;Stroke;symptomatic improvement;Symptoms;telehealth;Testing;theories;Therapeutic Intervention;therapy development;Training;Training Activity;translational model;Traumatic Brain Injury;United States;Universities;Washington;Work;Writing

PROJECT_TITLE: Optimizing a Telehealth Behavioral Intervention for Fatigue in People with Multiple Sclerosis

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Function, Integration, and Rehabilitation Sciences Study Section[CHHD-K]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;HIV/AIDS;Infectious Diseases;Orphan Drug;Rare Diseases;Tuberculosis

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE With the recent WHO and CDC endorsement of the shorter, all-oral BPaLM treatment regimen for drug resistant tuberculosis (DR-TB), simple, rapid molecular diagnostics for pre-treatment drug susceptibility testing are crucial for ensuring this regimen is used appropriately and new resistance to these drugs is prevented. The objective of this project is to develop and evaluate the performance of a novel, culture-free, single amplification sequencing solution for the detection of DR-TB for all legacy and new/repurposed drugs with known molecular targets (specifically isoniazid, rifampicin, pyrazinamide, amikacin, moxifloxacin, bedaquiline, clofazimine, linezolid, and delamanid). The technical and clinical knowledge gained from this project will translate directly into our goal of achieving an automated “sample-to-answer” sequencing system that can be deployed closer to the point of care than current sequencing diagnostics, and with significantly lower costs.

PI_NAMEs: COLMAN, REBECCA ELIZABETH;RODWELL, TIMOTHY CHARLES (contact)

PROGRAM_OFFICER_NAME: LACOURCIERE, KAREN A

PROJECT_TERMS: accurate diagnosis;Adherence;Adoption;Amikacin;Biological Assay;blind;Bypass;Catalogs;Characteristics;Clinical;Collaborations;Companions;Complex;cost;detection limit;Development;Diagnosis;Diagnostic;Dimensions;drug repurposing;Drug resistance;Drug resistance in tuberculosis;drug testing;Effectiveness;Ensure;field study;Foundations;Frequencies;Funding;Gene Targeting;Genotype;Goals;Grant;Hand;Health Personnel;Hour;human error;Incidence;India;instrument;Intermediate resistance;Investments;isoniazid;Knowledge;Laboratories;Leadership;Linezolid;Moldova;Molecular Diagnostic Testing;molecular diagnostics;molecular drug target;molecular recognition;Molecular Target;Moxifloxacin;Multi-Drug Resistance;Mutation;Mutation Detection;Mycobacterium tuberculosis;next generation sequencing;novel;novel therapeutics;Nucleic Acid Amplification Tests;Oral;Patient Care;Patients;Performance;Pharmaceutical Preparations;Phenotype;point of care;Predisposition;preservation;prevent;Process;profiles in patients;Pyrazinamide;rapid test;Recommendation;Reference Standards;Regimen;Resistance;Resistance profile;Resource-limited setting;Rifampicin resistance;Rifampin;Risk;Running;Sampling;skills;Solid;solid state;South Africa;Specificity;Sputum;System;Testing;Time;tool;Translating;treatment organization;Treatment Protocols;Tuberculosis;Tuberculosis diagnosis;tuberculosis drugs;tuberculosis treatment;United States National Institutes of Health;Update;uptake;Work;World Health Organization

PROJECT_TITLE: Automated Sequencing for Culture-free Diagnosis of Drug Resistant TB


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Aging;Breast Cancer;Cancer;Cancer Genomics;Endocrine Disruptors;Estrogen;Genetics;Human Genome;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: DUARTE

ORG_NAME: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE

PHR: Per- and poly-fluoroalkyl substances (PFAS) are pervasive and enduring environmental contaminants; and yet, despite the fact that they have been shown to interfere with human hormone systems and potentially cause cancer, there have been no significant, large-scale studies of their possible relationship to breast cancer. The goals of this project are to determine: a) whether exposure to these chemicals is associated with risk of developing breast cancer; and b) what the biologic effects of exposures to these chemicals are in normal human breast cells, in the blood of healthy women, and in women with breast cancer. This proposed research project will advance our understanding of the role of environmental chemicals in the development of breast cancer.

PI_NAMEs: NEUHAUSEN, SUSAN L. (contact);REYNOLDS, PEGGY

PROGRAM_OFFICER_NAME: BOYLES, ABEE

PROJECT_TERMS: 3-Dimensional;Address;age acceleration;age related;Age Years;aged;Aging;aging related;American Cancer Society;Animals;bead chip;Biological;Blood;Blood Banks;Blood specimen;Body Burden;Breast;Breast Cancer cell line;breast cancer diagnosis;Breast Cancer Risk Factor;Breast Epithelial Cells;Cancer Control;cancer diagnosis;Cancer Etiology;cancer initiation;cancer prevention;cancer risk;cancer subtypes;carcinogenicity;Carcinogenicity Tests;case control;Case/Control Studies;Cells;Chemical Exposure;Chemicals;cohort;Cytokeratin;Data;design;Development;Diagnosis;DNA Methylation;Endocrine;Endocrine Disruptors;Enrollment;environmental chemical;Environmental Exposure;Environmental Pollutants;epidemiology study;epigenome-wide association studies;Epithelial Cells;Epithelium;Etiology;Exposure to;Female;Foundations;Future;Genetic Transcription;Genome;Genomics;Goals;Health;Hormones;Human;in vivo;innovation;insight;interdisciplinary approach;interest;Link;Malignant Breast Neoplasm;Malignant Neoplasms;mammary;mammary epithelium;Mammary gland;Mammary Neoplasms;Measurement;Measures;Methodology;Methylation;methylome;Molecular;multidisciplinary;Mus;Myoepithelial cell;Outcome;Participant;Perimenopause;Plasma;Poly-fluoroalkyl substances;polybrominated diphenyl ether;Predisposition;Prevention strategy;prospective;Prospective Studies;Proteins;Research;Research Project Grants;Risk;Risk Factors;Role;Sampling;Seminal;stem cells;System;Testing;Tissues;United States Environmental Protection Agency;Woman;Women's study;Work

PROJECT_TITLE: Environmental Chemical Body Burden and Prospective Breast Cancer Risk in the Cancer Prevention Study-3 Cohort

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-N(91)S]


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Genetics;Human Genome;Immunotherapy;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: BOSTON

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

ORG_STATE: MA

PHR: Project Narrative Glioblastoma (GBM) is a lethal brain cancer with no effective treatment available due to its high heterogeneity and ineffective immune cell composition, which still remains uncharacterized especially during radiation and chemotherapy treatment. We will use advanced technologies in single cell analysis to determine the composition, activation and localization of the immune cells of GBM in patient samples and in mouse models that recapitulate features of human GBM before, during and after treating the animals with the same standard of care that patients receive. This research will uncover new information on how tumor cells and immune cells react to radiation and chemotherapy and interact with each other, which we will leverage to design new treatment modalities.

PI_NAMEs: BOUSSIOTIS, VASSILIKI A;CHAREST, ALAIN  (contact);VERHAAK, ROEL GW

PROGRAM_OFFICER_NAME: KAI, MIHOKO

PROJECT_TERMS: Address;Aftercare;Animals;Area;Bone Marrow;cancer cell;CDKN2A gene;Cell Communication;Cell Separation;Cells;checkpoint inhibition;checkpoint therapy;Chemotherapy and/or radiation;Clinical;clinically relevant;clinically significant;Data Set;design;Development;Dexamethasone;effective therapy;Epidermal Growth Factor Receptor;epidermal growth factor receptor VIII;Event;Evolution;Experimental Models;Flow Cytometry;Genetically Engineered Mouse;Genomics;Glioblastoma;Glioma;Heterogeneity;Human;human data;Immune;immune cell infiltrate;immune checkpoint blockade;immune resistance;Immunology;Immunosuppression;Immunotherapy;Infiltration;Inflammatory;insight;Institution;International;Ionizing radiation;Knowledge;Lesion;longitudinal analysis;Macrophage;Malignant - descriptor;Malignant neoplasm of brain;Malignant Neoplasms;Maps;Mediating;member;Microglia;Modality;Molecular;mouse model;Mouse Strains;multiple omics;multiplexed imaging;Mus;mutant;Mutation;Myelogenous;Myeloid Cells;Myeloid-derived suppressor cells;Nature;neoplastic;neoplastic cell;new therapeutic target;novel therapeutic intervention;Output;overexpression;Pathology;Pathway interactions;Patients;Population;Population Dynamics;pre-clinical;Property;protein biomarkers;PTEN gene;Radiation;Reaction;recruit;Research;Resistance;Sampling;Signal Transduction;single cell analysis;single-cell RNA sequencing;Spatial Distribution;standard of care;success;T-Lymphocyte;targeted treatment;Technology;temozolomide;The Cancer Genome Atlas;Therapeutic;therapeutic development;Time;transcriptome sequencing;transcriptomics;tumor;tumor immunology;Tumor Suppressor Genes;tumor-immune system interactions;Tumor-infiltrating immune cells;tumorigenic

PROJECT_TITLE: Understanding the cellular and functional changes in the immune tumor microenvironment of glioblastoma during progression and treatments.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CTH-B(55)R]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Aging;Atherosclerosis;Biotechnology;Cardiovascular;Genetics;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Heart Disease - Coronary Heart Disease;Human Genome;Kidney Disease;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: PROJECT NARRATIVE This project will leverage existing clinical, genetic and gene expression data to identify and characterize genetic risk factors for cardiovascular disease in individuals with chronic kidney disease. Findings from this study may provide insights into the biological mechanisms for cardiovascular susceptibility in this high-risk population, which may have implications for precision medicine.

PI_NAMEs: FRANCESCHINI, NORA  (contact);LI, YUN

PROGRAM_OFFICER_NAME: YAN, YE

PROJECT_TERMS: Acceleration;Accounting;Address;adjudication;Adult;African American;African American population;Age;Aorta;Atherosclerosis;Biological;Biological Markers;biomarker identification;brain tissue;burden of illness;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;Cardiovascular system;causal variant;Cause of Death;Cessation of life;Chromosome Mapping;Chronic Kidney Failure;Chronic Kidney Insufficiency;Clinical;clinical center;cohort;Cohort Studies;Collaborations;Complex;Coronary artery;coronary artery calcification;Coronary heart disease;Data;Data Set;disability;Disease;disease prognosis;Disease susceptibility;disorder prevention;Eligibility Determination;European ancestry;Event;gene discovery;Gene Expression;Gene Expression Profiling;Gene Expression Regulation;Genes;Genetic;genetic risk factor;genetic variant;Genome;genome sequencing;genome wide association study;genome-wide;Genomic Segment;Genotype;Genotype-Tissue Expression Project;Goals;health difference;Heart;Heart failure;high risk;high risk population;Individual;innovation;insight;Ischemic Stroke;Kidney;Knowledge;Linkage Disequilibrium;Longitudinal Studies;Medicare;Mental Depression;Methods;Mission;Modeling;monocyte;multi-ethnic;Multi-Ethnic Study of Atherosclerosis;Myocardial Infarction;National Heart, Lung, and Blood Institute;novel;Nucleic Acid Regulatory Sequences;Outcome;Participant;Pathway interactions;Patients;Peripheral arterial disease;Persons;pleiotropism;population health;precision medicine;Predisposition;programs;Publishing;Quantitative Trait Loci;recruit;Risk Factors;Role;secondary outcome;Stroke;Susceptibility Gene;targeted treatment;Testing;Tissues;trait;Trans-Omics for Precision Medicine;Transcript;transcriptome;Untranslated RNA;Variant;Veterans;Whole Blood;whole genome

PROJECT_TITLE: Genetics of Cardiovascular Disease in Chronic Kidney Disease

STUDY_SECTION: CHSA

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology A Study Section[CHSA]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Genetics;Infectious Diseases;Pediatric

ORG_CITY: Pretoria

ORG_COUNTRY: SOUTH AFRICA

ORG_FIPS: SF

ORG_NAME: UNIVERSITY OF PRETORIA

PHR: Project narrative We will monitor five gastroenteritis viruses both in children hospitalised with diarrhoea, and in wastewater from 11 treatment plants in nine provinces of South Africa. We will characterise the strain diversity of adenovirus, norovirus and rotavirus, which cause the most severe disease. We will determine which norovirus strains children are exposed to between birth and 2 years of age as well as the functionality of their antibody response.

PI_NAMEs: MANS, JANET  (contact)

PROGRAM_OFFICER_NAME: ALARCON, RODOLFO M

PROJECT_TERMS: 2 year old;5 year old;Adenoviruses;Age;age group;Antibodies;antibody detection;Antibody Response;Astrovirus;Avidity;Binding;Biological Assay;Birth;Blocking Antibodies;Blood;Blood Group Antigens;Blood specimen;Capsid Proteins;Characteristics;Child;Chimeric Proteins;Circulation;Classification;Clinical;Communities;Complement;Data;Diagnostic;Diarrhea;Dideoxy Chain Termination DNA Sequencing;Disease;Dryness;Enteral;Environment;experimental study;Exposure to;Gastroenteritis;Genetic Variation;Genome;Genomic Segment;Genotype;HIV;Hospitalization;Hospitalized Child;Human immunodeficiency virus test;Immune response;Immunoprecipitation;Infection;Laboratories;Life;Link;Luciferases;Maternal antibody;Metagenomics;Monitor;next generation sequencing;Norovirus;Pattern;Plants;Predisposition;Prevalence;Protein Microarray Assay;Protein Microchips;Province;response;Reverse Transcriptase Polymerase Chain Reaction;Rotavirus;Sapovirus;Secretor blood group alpha-2-fucosyltransferase;Sentinel;Seroepidemiologic Studies;Seroprevalences;Signal Transduction;South Africa;South African;Specimen;Spottings;Testing;Time;Variant;viral detection;Viral Gastroenteritis;virology;virome;Virus;Virus Diseases;wastewater samples;wastewater surveillance;Whole Blood

PROJECT_TITLE: Gastroenteritis virus infections in South African children: secretor status-linkedsusceptibility, prevalence and genetic diversity and humoral responses to norovirusinfection

STUDY_SECTION: EDIT

STUDY_SECTION_NAME: Etiology, Diagnostic, Intervention and Treatment of Infectious Diseases Study Section[EDIT]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Liver Disease;Nutrition

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: We propose that the development of liver disease associated with diet-induced obesity (i.e., non-alcoholic fatty liver disease, NAFLD) may be enhanced by vinyl chloride exposure, even below levels that are overtly hepatotoxic. We have demonstrated that VC increases the diet-stimulated inflammatory response in the liver via causing ER stress and mitochondrial dysfunction. The project will focus on this underappreciated risk- modifier and the detailed organelle-related mechanisms of liver injury caused by the interaction of VC and diet in experimental NAFLD.

PI_NAMEs: BEIER, JULIANE I (contact)

PROGRAM_OFFICER_NAME: GARCIA, MARTHA

PROJECT_TERMS: Address;adduct;Affect;Autophagocytosis;Autophagosome;Biochemical;Bioenergetics;Biology;Cancer Etiology;Carbohydrates;Cells;Chemicals;chloroacetaldehyde;Chloroquine;Cirrhosis;Complement;Data;Diet;diet-induced obesity;Disease;Endoplasmic Reticulum;endoplasmic reticulum stress;Environment;Environmental Exposure;Environmental Pollutants;Event;Exposure to;Fatty acid glycerol esters;Fatty Liver;fatty liver disease;Fibrosis;Functional disorder;Goals;Health;Hepatic;Hepatocyte;Hepatotoxicity;Human;Impairment;improved;in vitro Model;in vivo;indexing;Individual;Inflammatory Response;Inhalation;Injury;insight;Life Style;Liver;liver development;Liver diseases;liver injury;LoxP-flanked allele;Malignant neoplasm of liver;Membrane;Meta-Analysis;Metabolic;Metabolic syndrome;Metabolism;Mitochondria;mitochondrial dysfunction;Molecular;Molecular Chaperones;Monitor;Mus;National Institute of Diabetes and Digestive and Kidney Diseases;new therapeutic target;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;novel therapeutics;Obesity Epidemic;Occupational;Organelles;Oxidative Stress;Peptides;Physiological;preservation;Prevalence;prevent;Process;protein complex;Proteins;Quality Control;Regulation;Reporter;Resistance;Risk;Risk Factors;Role;Safety;Shelter facility;Site;Strategic Planning;Stress;Sulfhydryl Compounds;tauroursodeoxycholic acid;Testing;Therapeutic;Therapeutic Effect;therapeutic evaluation;Thinness;Toxic Environmental Substances;toxicant;Toxicant exposure;Translating;Vinyl Chloride;Work

PROJECT_TITLE: Vinyl chloride modifies the risk for nonalcoholic fatty liver disease

STUDY_SECTION: XNDA

STUDY_SECTION_NAME: Xenobiotic and Nutrient Disposition and Action Study Section[XNDA]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Genetics;Mental Health;Neurosciences

ORG_CITY: HOUSTON

ORG_DEPT: NEUROSCIENCES

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: PROJECT NARRATIVE Activation of the integrated stress response (ISR), a conserved signaling network that restores protein homeostasis by regulating protein synthesis, is emerging as a main causative mechanism underlying the memory deficits in a wide range of cognitive disorders. By using a novel human-based mouse model and a multidisciplinary approach that combines mouse genetics, molecular biology, electrophysiology, pharmacology, chemical biology and behavioral studies, we aim to define the precise molecular, cellular, and circuit mechanisms by which activation of the ISR leads to cognitive dysfunction. By providing new fundamental insights into the mechanisms by which inhibition of the ISR reverses cognitive dysfunction our studies could lead to the development of new treatments for cognitive disorders resulting from perturbation of protein homeostasis.

PI_NAMEs: PFAFFINGER, PAUL  (contact);RAY, RUSSELL S;WATKINS, TRENT

PROGRAM_OFFICER_NAME: LEENDERS, MIRIAM

PROJECT_TERMS: Animal Model;Automobile Driving;Behavior;Behavioral;behavioral study;Biological;biological adaptation to stress;Biological Assay;Biology;Brain;brain cell;cell growth;cell type;Chemicals;Cognition Disorders;CRISPR/Cas technology;design;Development;Disease;Dissection;drug discovery;Economics;effective therapy;Electrophysiology (science);excitatory neuron;Exhibits;experimental study;Genes;Genetic;genetic approach;Genetic Models;genome sequencing;Genomics;Goals;Growth;high throughput screening;Human;Impaired cognition;Impairment;in vivo;Incidence;Individual;inhibitor;inhibitory neuron;insight;Intellectual functioning disability;interdisciplinary approach;Knowledge;Light;long term memory;loss of function;Mammalian Cell;Mediating;Memory Disorders;Memory impairment;Missense Mutation;Modeling;Molecular;Molecular Biology;Molecular Genetics;Monitor;mouse genetics;mouse model;mRNA Translation;Mus;Mutation;Neurodegenerative Disorders;Neuroglia;novel;novel therapeutic intervention;novel therapeutics;Pathogenesis;Pathway interactions;pharmacologic;Pharmacology;Phosphotransferases;programs;Protein Biosynthesis;proteostasis;Public Health;Reporter;ribosome profiling;Role;screening;Signal Transduction;single-cell RNA sequencing;small molecule inhibitor;social;Synapses;synaptic function;Synaptic plasticity;Testing;tool;Translations;whole genome;Yeasts

PROJECT_TITLE: The integrated stress response in cognitive disorders


NIH_SPENDING_CATS: Biotechnology;Gene Therapy;Genetics;Immunotherapy;Kidney Disease;Organ Transplantation;Regenerative Medicine;Transplantation

ORG_DEPT: SURGERY

PHR: Project Narrative Kidney transplantation remains limited by a critical shortage of donor organs and suboptimal graft longevity due to alloimmune injury. Targeted delivery of gene therapies to improve function and longevity of donor kidneys has become feasible through the use of ex vivo machine perfusion platforms. This approach has significant potential to improve long-term outcomes in solid organ transplantation.

PI_NAMEs: ASOKAN, ARAVIND ;BARBAS, ANDREW SERGHIOS (contact);KIRK, ALLAN D.

PROGRAM_OFFICER_NAME: KULKARNI, SHILPA S

PROJECT_TERMS: Address;adeno-associated viral vector;adenovirus mediated delivery;Adenovirus Vector;Allografting;allotransplant;Autologous Transplantation;Body System;cell type;Cells;Chronic;Clinical;clinical development;clinical translation;clinically relevant;cross reactivity;Cryopreservation;Dependovirus;design;Development;End stage renal failure;Engineering;Evolution;ex vivo perfusion;experimental study;Family suidae;functional improvement;Gene Delivery;gene therapy;Gene Transduction Agent;gene-targeted therapy;Genes;Genetic Engineering;Goals;graft function;Graft Survival;Green Fluorescent Proteins;heart allograft;Heart Transplantation;high risk;Human;Immune;Immune response;immunogenicity;Immunologics;immunoregulation;Immunosuppression;improved;Individual;Injury;Kidney;kidney allograft;Kidney Transplantation;Libraries;liver transplantation;Longevity;Lung Transplantation;Mediating;Methods;Modeling;nonhuman primate;novel;novel strategies;Organ;Organ Donor;organ repair;Organ Transplantation;Outcome;overexpression;Patients;Perfusion;post-transplant;Pre-Clinical Model;Process;programmed cell death ligand 1;rational design;Rattus;Regimen;Reporter;Reporter Genes;Research;Research Personnel;response;Safety;single-cell RNA sequencing;Solid;System;targeted delivery;Testing;therapeutic gene;Time;transgene delivery;transgene expression;Transgenes;transplant model;Transplantation;Tropism;United States;uptake;Viral;Virus;Work

PROJECT_TITLE: Genetic engineering of kidney allografts by ex vivo perfusion delivery of adeno-associated viral vectors


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric

ORG_CITY: NEW YORK

ORG_DEPT: PSYCHIATRY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: PROJECT NARRATIVE Disruptive mutations in the gene CHD8 (Chromodomain Helicase DNA-binding protein 8) are risk factors for autism spectrum disorder (ASD), a complex chronic neurodevelopmental disorder associated with life-long morbidity and increased mortality. Converging lines of research implicate dysfunctional basal ganglia circuits, particularly the dopaminergic system, in the core symptoms of ASD, and preliminary data indicates that CHD8 is a potential regulator of these circuits. The studies proposed in this application will integrate state-of-the-art single nuclear transcriptomics and cell type specific functional genomics, with electrophysiologic, optogenetic and behavioral probing of animal models of CHD8 haploinsufficiency to close a critical knowledge gap in the role of CHD8 in dopaminergic circuitry, thus providing insight into the biological underpinnings of ASD biology to inform future translational studies.

PI_NAMEs: MUHLE, REBECCA ANN (contact)

PROGRAM_OFFICER_NAME: LEINWAND, SARAH GOLDBERG

PROJECT_TERMS: Affect;Animal Model;ATAC-seq;Atlases;Attenuated;autism spectrum disorder;autism symptoms;Basal Ganglia;Behavior;Behavioral;behavioral impairment;Binding;Biological;Biology;Biotinylation;Brain;Brain Diseases;Cell Physiology;cell type;Cells;Cellular biology;Child;ChIP-seq;Chromatin;chromatin immunoprecipitation;chromatin remodeling;Chronic;Collaborations;Complex;Corpus striatum structure;Cre driver;Critical Pathways;Data;Data Set;Defect;Development;DNA;DNA Sequence Alteration;DNA-Binding Proteins;Doctor of Medicine;Doctor of Philosophy;Dopamine;Dopamine Agonists;Dopamine Receptor;dopamine system;dopamine transporter;dopaminergic neuron;Electrophysiology (science);Epigenetic Process;epigenetic profiling;extracellular;Fellowship;Female;Fiber;Foundations;functional genomics;Funding;Future;Gene Expression;Genes;Genetic Risk;Genetic Transcription;Genomic Segment;Genomics;Goals;helicase;Human;in vivo;insight;Investigation;Knowledge;Label;Lifestyle-related condition;LoxP-flanked allele;male;Maps;Mentorship;Microdialysis;Midbrain structure;Modeling;Molecular;Molecular Abnormality;Molecular Genetics;Morbidity - disease rate;mortality;mouse model;multiple omics;Mus;Mutation;National Institute of Mental Health;neurobehavioral disorder;Neurobiology;Neurodevelopmental Disorder;Neurons;neurotransmission;novel;novel therapeutics;Nuclear;Nuclear RNA;optogenetics;Outcome;Pathway interactions;Pharmaceutical Preparations;Photometry;Play;Population;postsynaptic;presynaptic;promoter;Psychiatrist;Public Health;Regulation;repetitive behavior;Research;Research Personnel;Resolution;response;Risk;Risk Factors;risk variant;Role;sex;social;Societies;Specific qualifier value;stereotypy;Stimulus;Structure;Synapses;System;tool;trait;transcriptome sequencing;transcriptomic profiling;transcriptomics;Transgenes;translational study;transmission process;Universities

PROJECT_TITLE: IMPACT OF LOSS OF THE AUTISM RISK GENE CHD8 ON EXPRESSION, EPIGENETICS AND CELLULAR FUNCTIONING OF THE DOPAMINERGIC SYSTEM

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MDCN-P(57)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Depression;Drug Abuse (NIDA only);Genetics;Human Genome;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Opioid Misuse and Addiction;Opioids;Prevention;Serious Mental Illness;Substance Misuse

ORG_CITY: BALTIMORE

ORG_NAME: LIEBER INSTITUTE, INC.

ORG_STATE: MD

PHR: PROJECT NARRATIVE Emerging evidence suggests that dysregulation of the habenula, a region of the human brain that acts as a key node of reward circuitry governing motivated behavior and mood, is associated with both drug addiction and psychiatric disorders. In this application, we will generate a molecular neuroanatomical map of human habenula at single cell and spatial resolution and define genetic changes in this region across depression and opioid use disorder. These data will be used to better understand the molecular correlates of substance use and comorbid neuropsychiatric disorders.

PI_NAMEs: MAYNARD, KRISTEN ROSE (contact)

PROGRAM_OFFICER_NAME: SATTERLEE, JOHN S

PROJECT_TERMS: addiction;Affective;Anatomy;Architecture;Atlases;Autopsy;Brain;Brain region;cell type;Cells;Chromium;Clinical;cognitive function;comorbidity;COVID-19 pandemic;Critical Pathways;Data;data integration;Data Set;differential expression;Disease;Drug Addiction;Environmental Risk Factor;Epigenetic Process;Functional disorder;Gene Expression;Gene Expression Profile;Gene Expression Regulation;Genes;Genetic;genetic association;Genetic Risk;Genome Mappings;genome wide association study;Genomics;Habenula;Heritability;high risk;Human;Impairment;Lateral;Location;Major Depressive Disorder;Maps;Measures;Medial;Mediating;Mental Depression;Mental disorders;Molecular;mood regulation;Moods;mortality;motivated behavior;Motivation;multimodality;Mutation;Neuroanatomy;neuropsychiatric disorder;neuropsychiatry;novel;Nucleus Accumbens;Opiate Addiction;Opioid;opioid epidemic;opioid use disorder;Output;pandemic disease;Patients;Population;Positioning Attribute;Prefrontal Cortex;Prevention;psychiatric comorbidity;Publishing;Quantitative Trait Loci;Regulatory Pathway;Resolution;Resources;reward circuitry;Rewards;Risk;risk variant;Rodent;Serotonin;Signal Transduction;single nucleus RNA-sequencing;single-cell RNA sequencing;spatial integration;Stressful Event;Structure;substance use;Substance Use Disorder;System;Taxonomy;Technology;Tissues;transcriptome;transcriptome sequencing;transcriptomics

PROJECT_TITLE: Regulation of Gene Expression in the Human Habenula in Comorbid Opioid Addiction and Depression

STUDY_SECTION: PMDA

STUDY_SECTION_NAME: Pathophysiological Basis of Mental Disorders and Addictions Study Section[PMDA]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Foodborne Illness;Infectious Diseases

ORG_CITY: TAMPA

ORG_NAME: UNIVERSITY OF SOUTH FLORIDA

ORG_STATE: FL

PHR: Project Narrative Toxoplasma gondii is an important human pathogen that causes life long infection in millions of people. To achieve efficient transmission to the next host, T. gondii must maintain a balance between replication and development into dormant forms that evade host immunity. We are studying central mechanisms that regulate the transition from proliferative tachyzoite to latent bradyzoite state of the parasite responsible for currently incurable chronic toxoplasmosis.

PI_NAMEs: SUVOROVA, ELENA  (contact)

PROGRAM_OFFICER_NAME: MCGUGAN, GLEN C

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Acute;Affect;Animal Model;Animals;Architecture;Auxins;Biochemical;Biological;Biological Assay;Biology;Cell Cycle;Cell division;Cells;chemotherapy;Chronic;Chronic Disease;Clinical;Complex;Cyclins;Cyst;Development;differential expression;Differentiation and Growth;Disease;Disease Outbreaks;Disease Progression;Drug Targeting;effective therapy;Ensure;Equilibrium;Eukaryota;Evaluation;experience;experimental study;Foundations;Frequencies;G1 Phase;Gene Expression;Genetic;Genetic Models;Genome;Goals;Human;human pathogen;immune function;Immune response;Immune system;Immunity;Immunocompromised Host;immunodeficiency;In Vitro;in vitro activity;in vivo;Individual;Infection;Kentucky;Life;Link;Measures;Mechanics;Mediating;Modeling;Monitor;Mothers;mouse model;Mus;mutant;novel;Organ Transplantation;Parasites;Parasitic infection;Patients;Persons;Pharmaceutical Preparations;Phosphotransferases;Population;Post-Translational Protein Processing;Pregnancy;prenatal;prevent;protein expression;Proteomics;Readiness;Regulation;Rest;Role;Specialist;success;Testing;Time;Toxoplasma;Toxoplasma gondii;Toxoplasmosis;transmission process;Universities;Woman

PROJECT_TITLE: Cyclin-mediated control of Toxoplasma development

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDM-M(02)]


NIH_SPENDING_CATS: Bioengineering;Kidney Disease

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

PHR: Podocytopathies are glomerular diseases that harm the kidney filter and are the culprit in many kidney diseases, such as minimal change disease, focal segmental glomerulosclerosis and diabetic nephropathy. Proper understanding of how podocytes work, and how they regulate their actin cytoskeleton in health, disease and recovery, will allow us to develop better therapies for these diseases. In this proposal, we will apply a set of novel imaging approaches, including super- resolution microscopy, a newly developed membrane-extraction electron microscopy technique, and a novel method of visualizing primary podocytes in culture, to investigate some fundamental questions regarding the podocyte actin cytoskeleton.

PI_NAMEs: SULEIMAN, HANI  (contact)

PROGRAM_OFFICER_NAME: SADUSKY, ANNA BURKART

PROJECT_TERMS: 3-Dimensional;Actin-Binding Protein;Actins;Actomyosin;Affect;Appearance;Architecture;Area;beta Actin;biological systems;Biology;biophysical properties;blood filter;blood filtration;Cell Culture Techniques;Cell Shape;cell type;Cells;Culture Techniques;Cytoskeleton;Data;design;Diabetic Nephropathy;Disease;Electron Microscopy;Embryo;Epithelial Cells;Equilibrium;Evolution;Extracellular Matrix;Focal and Segmental Glomerulosclerosis;Foot Process;gamma Actin;Genes;Genetic Models;genetic variant;glomerular basement membrane;Glomerular Capillary;glomerular filtration;Goals;Guanosine Triphosphate Phosphohydrolases;Health;Homeostasis;Hydrogels;Image;imaging approach;Imaging Techniques;Imaging technology;injured;Injury;Isoactin;Kidney;Kidney Diseases;Kidney Failure;Kidney Glomerulus;Knockout Mice;Labyrinth;Lead;Link;Machine Learning;Mechanics;Membrane;Methods;Microfilaments;Microscopy;Modeling;Molecular;Monomeric GTP-Binding Proteins;Morphology;mouse genetics;mouse model;Mus;Nature;Nonmuscle Myosin Type IIA;novel;novel therapeutic intervention;Optics;Pathway interactions;Pattern;Physical condensation;Play;podocyte;Process;Protein Isoforms;reconstruction;Recovery;Regulation;Renal function;Renal glomerular disease;Resolution;response to injury;rho;rho GTP-Binding Proteins;Role;Sarcomeres;slit diaphragm;Spatial Distribution;Specific qualifier value;Structure;superresolution imaging;superresolution microscopy;System;Techniques;Testing;Thick;Three-Dimensional Imaging;transcriptome sequencing;Tropomyosin;Visualization;Western Blotting;Work

PROJECT_TITLE: Molecular Determinants of Kidney Podocyte Architecture in Health, Injury, and Recovery

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Eye Disease and Disorders of Vision;Neurosciences

PHR: PROJECT NARRATIVE Neurons receive hundreds or thousands of synaptic inputs on their dendritic trees; each input can change the voltage slightly, and all of the voltage changes are added up and amplified in complex ways to determine if the neuron will generate an output. Observing this process of electrical integration is difficult because dendrites are small. In this project we will test the ability of advanced microscopy techniques and new fluorescent voltage sensors to reveal this process in action in the intact brain.

PI_NAMEs: REIMER, JACOB  (contact)

PROGRAM_OFFICER_NAME: DAVID, KAREN KATE

PROJECT_TITLE: Validation and Optimization of Two-Photon Dendritic Voltage Imaging in Vivo

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ICN-N(55)R]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering

ORG_DEPT: BIOMEDICAL ENGINEERING

PHR: PROJECT NARRATIVE Metrics by which induced tissue damage during histotripsy – a non-invasive, ultrasound based, mechanical tis- sue ablation modality – can be monitored in situ during treatment do not currently exist. This project seeks to develop such metrics, as well as strategies for monitoring them in situ, by measuring the acoustic cavitation emission (ACE) signals emitted by the histotripsy-generated cavitation events during therapy, and correlating features of these ACE signals with material properties and damage induced to targeted gel phantoms and tissues in ex vivo and in vivo settings. Developing metrics to assess induced tissue damage, and to monitor them in situ, are vital for ensuring histotripsy treatment efficacy and for securing future FDA approval for histotripsy’s clinical use.

PI_NAMEs: SUKOVICH, JONATHAN ROBERT (contact)

PROGRAM_OFFICER_NAME: KING, RANDY LEE

PROJECT_TERMS: Ablation;Acoustics;Affect;Algorithms;Animal Model;Blood coagulation;Brain;Clinical;clinical translation;Clinical Trials;cranium;Data;Deposition;Development;Dose;efficacy validation;Elements;Ensure;Erythrocytes;Europe;Event;experimental study;Exposure to;Family suidae;Feedback;Focused Ultrasound Therapy;Fractionation;Future;Gel;Generations;Heating;Histologic;Histology;Human;Hydrogels;Image;In Situ;in vivo;Kidney;Literature;Liver;liver tumor ablation;Location;Measures;mechanical properties;mechanical signal;Mechanics;Methods;Modality;Monitor;Operative Surgical Procedures;Optics;Outcome;outcome prediction;Pathology;Patients;Phase;Physiologic pulse;porcine model;prediction algorithm;Prediction of Response to Therapy;Procedures;Process;Property;Prostate;Radiation;Radiation Dose Unit;Radiation therapy;Radiation Toxicity;Radiofrequency Interstitial Ablation;rib bone structure;risk minimization;Safety;Secondary to;Secure;side effect;Signal Transduction;Spleen;System;Techniques;Technology;therapy outcome;Thermometry;Time;Tissues;transmission process;Treatment Efficacy;Ultrasonic Therapy;Ultrasonography;ultrasound;Visual;Work

PROJECT_TITLE: Acoustic Cavitation Emission (ACE) Feedback Methods for Monitoring Histotripsy-Induced Tissue Fractionation In Situ


NIH_SPENDING_CATS: Aging;Brain Disorders;Genetics;Neurodegenerative;Neurosciences;Parkinson's Disease;Prevention;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: BELMONT

ORG_NAME: MCLEAN HOSPITAL

PHR: Project Narrative: Parkinson’s disease (PD) is a common neurodegenerative disorder affecting more than a million patients in the USA alone, and currently there are no treatments that can halt or slow down the disease progression. The nuclear receptor Nurr1 is essential not only for development and maintenance but also for protection of midbrain dopamine neurons from inflammatory insults, rendering it a promising drug target for PD. Based on our recent data identifying synthetic and native ligands that can interact with the ligand binding domain of Nurr1, leading to its activation, we will systematically investigate how these ligands regulate Nurr1’s crosstalk with genetic and environmental risk factors of PD (e.g., -synuclein and neurotoxin) and whether they can translate into future therapeutic development for neuroprotective and disease-modifying treatment of PD.

PI_NAMEs: KIM, KWANG-SOO  (contact)

PROGRAM_OFFICER_NAME: SULLIVAN, LUIS FLANAGAN

PROJECT_TERMS: 1-Methyl-4-phenylpyridinium;Address;Adopted;Affect;age related;aging brain;Alprostadil;Amodiaquine;Animal Model;Behavior;Behavioral;Biological Assay;Brain;Brain Diseases;Cells;Cessation of life;Chloroquine;Complex;Data;Dependovirus;Development;Disease;Disease Progression;dopaminergic neuron;Down-Regulation;Drug Targeting;druggable target;Dyskinetic syndrome;Effectiveness;Environmental Risk Factor;Exposure to;FDA approved;Future;Genes;Genetic;genetic risk factor;Genetic Transcription;Glafenine;Health;high throughput screening;Homologous Gene;Immune;Impaired cognition;improved;in vitro Model;in vivo Model;Infiltration;Inflammatory;inhibition of autophagy;knock-down;Laboratories;Lewy Bodies;Libraries;Ligand Binding Domain;Ligands;Link;Maintenance;Mediating;Microglia;Midbrain structure;Modeling;Molecular;motor disorder;mutant;Mutation;Neurodegenerative Disorders;neuroinflammation;neuron development;neuron loss;neuronal survival;neuroprotection;Neurotoxins;novel;novel therapeutics;NR4A2 gene;Nuclear Orphan Receptor;Nuclear Receptors;Olfactory dysfunction;overexpression;Oxidative Stress Induction;Parkinson Disease;Pathogenesis;Pathogenicity;Pathologic;Patients;Peripheral;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacologic;Physiological;Play;Proteins;Recovery;Regulation;Risk Factors;Role;scaffold;side effect;sporadic Parkinson's Disease;Structure-Activity Relationship;Substantia nigra structure;symptom treatment;synuclein;System;targeted treatment;Testing;therapeutic development;Transcription Coactivator;transcription factor;Transcription Repressor;Transcriptional Regulation;Translating;Work

PROJECT_TITLE: Crosstalk Between Nurr1 and Risk Factors of Parkinson's Disease and its Regulation by Nurr1's Ligands

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biotechnology;Brain Disorders;Drug Abuse (NIDA only);Genetics;Human Genome;Neurosciences;Opioid Misuse and Addiction;Opioids;Prescription Drug Misuse;Substance Misuse

PHR: Project Narrative The recent surge in misuse of prescription opioids as pain killers and the easy accessibility to illegal opioids, such as heroine and fentanyl, have contributed to the current epidemic of opioid overdoses. Better treatments of opioid use disorder (OUD) are urgently needed to produce long-term recovery and avoid relapse of drug use in vulnerable individuals. However, our knowledge of how opioids affects different brain systems during disease progression is limited. Here, we will use single cell genomics to define how different cell types in the brain respond to opioid use during different stages of disease progression in a rodent model of addiction.

PI_NAMEs: DE GUGLIELMO, GIORDANO ;TELESE, FRANCESCA  (contact)

PROJECT_TERMS: Acute;addiction;Addictive Behavior;Affect;Amygdaloid structure;Analgesics;Animal Model;Atlases;Behavioral;Behavioral Model;behavioral phenotyping;Biological;Biological Assay;Brain;brain cell;Brain region;brain tissue;Candidate Disease Gene;Cell Nucleus;cell type;Cells;Chromatin;Chronic;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Computer Analysis;CRISPR/Cas technology;Cue-induced relapse;Data;Data Set;Development;Disease;Disease Progression;Drug abuse;Drug Kinetics;drug relapse;Drug usage;Epigenetic Process;epigenome;epigenomics;Exposure to;Female;Fentanyl;Funding;Future;Gene Expression;Gene Expression Profiling;gene regulatory network;Genes;Genetic Transcription;Genome;genomic data;Genomics;Goals;Grant;Habenula;Heroin;Human;Hypothalamic structure;illicit opioid;In Situ;In Situ Hybridization;in vivo;Individual;innovation;Intravenous;Investigation;knock-down;Knowledge;Lateral;Link;long term recovery;male;Maps;Measurement;Measures;Mediating;Messenger RNA;Methodology;Modeling;Molecular;multimodality;multiple omics;National Institute of Drug Abuse;neuroadaptation;Neuroanatomy;Nucleus Accumbens;Opiate Addiction;Opioid;opioid epidemic;opioid exposure;opioid misuse;opioid mortality;opioid overdose;opioid use;opioid use disorder;Overdose;Oxycodone;oxycodone self-administration;Pain Disorder;Prefrontal Cortex;prescription opioid misuse;prescription pain reliever;Prevention;Process;prolonged abstinence;Protocols documentation;Public Health;Rattus;Regulatory Element;Research;Resolution;response;Risk Factors;RNA;Rodent Model;Role;Saline;Sampling;Scientist;Self Administration;single cell genomics;Substance abuse problem;synthetic opioid;System;Technology;Time;Tissues;Transcriptional Regulation;transcriptome;transcriptomics;United States;Validation;Viral;Vulnerable Populations;Withdrawal;XCL1 gene

PROJECT_TITLE: Multiomic profiling of cell types mediating opioid use disorder in rats


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative The ASPIRE project aims to improve patient safety for individuals using high-risk immunosuppressive medications. The proposed research will contribute novel information about emerging patient safety errors, rigorously evaluate a registry-based healthcare quality measurement program, and create the first toolkit to address ambulatory patient safety for immune-mediated diseases.

PI_NAMEs: YAZDANY, JINOOS  (contact)

PROGRAM_OFFICER_NAME: BAINGER, ELIZABETH

PROJECT_TITLE: Advancing Safety Process Innovation in Rheumatology (ASPIRE)

STUDY_SECTION: HSQR

STUDY_SECTION_NAME: Healthcare Patient Safety and Quality Improvement Research[HSQR]


ORG_CITY: WASHINGTON

ORG_DEPT: MISCELLANEOUS

ORG_NAME: GEORGE WASHINGTON UNIVERSITY

ORG_STATE: DC

PHR: Numerous research projects utilize large electronic health record datasets containing standardized codes, without tools to assess if the codes are used consistent with their intended use. We have termed this consistent use of the codes as representational semantic integrity. Because violations of representational semantic integrity will propagate errors in subsequent large scale data analyses of patient records, the proposed project will develop and validate advanced statistical and machine learning methods to assess and improve representational semantic integrity in large clinical databases.

PI_NAMEs: NELSON, STUART JAMES;ZENG, QING  (contact)

PROGRAM_OFFICER_NAME: PATEL, SHEENA

PROJECT_TITLE: Improving health data quality by assessing and enhancing semantic integrity

STUDY_SECTION: HITR

STUDY_SECTION_NAME: Healthcare Information Technology Research[HITR]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

ORG_CITY: KINGSTON

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF RHODE ISLAND

ORG_STATE: RI

PHR: PROJECT NARRATIVE The University of Rhode Island proposes creating the URI ESTEEMED program to provide academic enrichment, develop research skills, and support a dynamic scholar community to encourage individuals from diverse backgrounds to pursue further studies and careers in bioengineering and related fields. The URI ESTEEMED program will nurture freshman and sophomore students from underrepresented backgrounds through a multi-year training program in which they gain invaluable experiences and skills enabling them to participate in mentored research and self-identify as researchers and bioengineers. With this comprehensive support strategy, URI ESTEEMED will develop a cohort of diverse students who possess the technical and soft skills necessary to excel in advanced research programs and ultimately pursue Ph.D. or M.D./Ph.D. degrees.

PI_NAMEs: MEENACH, SAMANTHA  (contact)

PROGRAM_OFFICER_NAME: GATLIN, TINA L

PROJECT_TERMS: Academic advising;academic preparation;Academic support;Bachelor's Degree;Biological Sciences;Biomedical Engineering;Biomedical Research;biomedical scientist;bridge program;career;CCL7 gene;cohort;Communities;community building;community college;Community Developments;Critical Thinking;curriculum development;Data;Degree program;design;Development;disadvantaged background;Discipline;Doctor of Medicine;Doctor of Philosophy;Doctor's Degree;Education;Educational Activities;efficacy evaluation;Eligibility Determination;Engineering;engineering design;Enrollment;Environment;equity, diversity, and inclusion;experience;Exposure to;Faculty;faculty mentor;Female;fundamental research;Funding;Goals;Graduate Degree;High School Student;improved;Individual;Institution;interest;Leadership;Lesbian Gay Bisexual Transgender Queer;matriculation;Mentors;Mission;Nature;Outcome;Participant;peer;peer coaching;Performance;Play;Positioning Attribute;Preparation;professor;programs;Qualifying;Readiness;recruit;Research;Research Activity;Research Personnel;Research Training;Resources;Rhode Island;Role;Running;Scholars Program;Scientific Inquiry;Scientist;Self Efficacy;skill acquisition;skills;skills training;Structure;student training;Students;success;summer research;Technical Expertise;Training;Training Activity;Training Programs;undergraduate research;undergraduate research experience;undergraduate student;Underrepresented Populations;Underrepresented Students;United States National Institutes of Health;Universities;Vision;Woman

PROJECT_TITLE: ESTEEMED Scholars Program at the University of Rhode Island


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Crohn's Disease;Digestive Diseases;Genetics;Human Genome;Inflammatory Bowel Disease;Machine Learning and Artificial Intelligence;Precision Medicine

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: NARRATIVE Crohn’s disease (CD) is a chronic inflammatory disease of the gastrointestinal tract, which affects nearly 1 million Americans. Several classes of immune suppressive therapy are approved for the treatment of CD but patients will often fail several classes of therapy before finding an effective medication. The proposed research will advance our understanding of transcriptional, genomic, and clinical predictors of anti-IL-12/23 therapy response allowing for improved selection of first-line therapy, which in turn may reduce costs associated with unnecessary biologic exposure and disease progression.

PI_NAMEs: CUSHING-DAMM, KELLY COLLEEN (contact)

PROGRAM_OFFICER_NAME: PAWLIKOWSKA, LUDMILA SYLWIA

PROJECT_TERMS: Abdominal Infection;adaptive immunity;Affect;American;Attention;Autoimmune;Behavior;Biological;biomarker identification;career development;cell type;Cells;Chronic;chronic inflammatory disease;Clinical;Clinical Data;clinical heterogeneity;clinical predictors;Clinical Trials;cohort;cost;Crohn's disease;Data;Decision Trees;Digestive System Disorders;Disease;Disease Progression;disorder control;Drug Targeting;evidence base;Exposure to;Funding;Gastrointestinal Diseases;Gene Expression;Gene Expression Profiling;Genes;Genetic;Genetic Markers;Genetic Risk;Genetic Transcription;genetic variant;genome wide association study;genome-wide;genomic data;genomic predictors;Genotype;Goals;Health;Health Care Costs;Heterogeneity;Immune;improved;Inflammatory;Inflammatory Bowel Diseases;insight;Institution;interest;Interleukin-12;Intestinal Diseases;Intestinal Obstruction;Intra-abdominal;Investigation;Lead;Learning;Location;Machine Learning;Malignant Neoplasms;Mediating;Metadata;Molecular;Morbidity - disease rate;Natural Immunity;novel;Outcome;Pathogenesis;Pathway Analysis;Pathway interactions;Patient Selection;Patients;Pattern;Performance;personalized care;Pharmaceutical Preparations;Positioning Attribute;precision medicine;predicting response;Predisposition;Price;prognostic;programs;Psoriasis;Research;response;response biomarker;Risk;risk variant;Selection for Treatments;Severities;Signal Transduction;skin disorder;statistics;Testing;Therapeutic;therapy outcome;Tissues;TNF gene;tool;Training;transcriptome;transcriptomics;treatment response;Trees;Variant

PROJECT_TITLE: Precision Medicine in Inflammatory Bowel Disease: Refining the Clinical and Genomic Predictors of Response to Anti-IL-12/23 Therapy

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


NIH_SPENDING_CATS: Cancer;Genetics

ORG_DEPT: PHARMACOLOGY

PHR: Cancers commonly exhibit dysfunctional redox resulting in elevated reactive oxygen species which can damage cellular DNA, especially the telomeres. Cancer cells must maintain their telomeres to survive and proliferate, and many achieve this by upregulating the alternative lengthening of telomeres (ALT) pathway, which relies on homology directed repair to restore telomeres. ALT is typically associated with aggressive cancers and poor prognosis. This proposal will advance our understanding of how oxidative damage in the telomeres regulates ALT activity and modulates telomere structures involved in ALT. Ultimately, this knowledge will be useful for developing new strategies that deplete telomeres to halt dividing malignant cells.

PI_NAMEs: MYONG, SUA ;OPRESKO, PATRICIA L (contact)

PROGRAM_OFFICER_NAME: WITKIN, KEREN L

PROJECT_TERMS: Acceleration;Alanine Transaminase;base;Biochemical;cancer cell;Cancer cell line;Catalogs;Cell Death;Cell division;cell injury;Cell Line;Cell Proliferation;Cell Survival;Cells;Chromosomal Instability;Chromosomes;Complex;cytotoxic;Data;detection platform;DNA;DNA biosynthesis;DNA lesion;DNA replication fork;Dyes;Equilibrium;Excision;Exhibits;experimental study;Functional disorder;G-Quartets;Genetic;Genome Stability;Genomic Instability;Goals;Grant;homologous recombination;Human;Impairment;in vivo;innovation;Invaded;Knowledge;Length;Lesion;Ligands;Malignant - descriptor;Malignant Neoplasms;Measures;Mediating;Mitotic;Mus;Mutation;OGG1 gene;Oxidation-Reduction;oxidative damage;oxidative DNA damage;Oxidative Stress;Pathway interactions;Phenotype;Physiological;Predisposition;Premalignant Cell;preservation;Production;Prognosis;Proliferating;Proteins;RAD52 gene;Reactive Oxygen Species;recruit;Regulation;repaired;replication stress;restoration;RNA;Role;Series;single molecule;single-molecule FRET;Single-Stranded DNA;Sister Chromatid Exchange;Somatic Mutation;Source;Structure;Telomerase;telomere;telomere loss;Telomere Maintenance;Telomere Pathway;Telomere Shortening;TERF1 gene;Testing;Time;tool;tumor;Visualization;Yeasts

PROJECT_TITLE: Roles of Telomeric Oxidative DNA Lesions in Telomere Length Regulation

STUDY_SECTION: CE

STUDY_SECTION_NAME: Cancer Etiology Study Section[CE]


NIH_SPENDING_CATS: Brain Disorders;Cardiovascular;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Heart Disease;Hematology;Neurosciences;Prevention;Rehabilitation;Stroke

ORG_CITY: NEW HAVEN

ORG_DEPT: NEUROLOGY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Patients who survive the acute phase of intracerebral hemorrhage have the potential to recover but also face a high risk of complications such as recurrent stroke. The risk of ischemic stroke is especially high in those with atrial fibrillation. The use of anticoagulant therapy to prevent further prevent brain injury in this vulnerable patient population has the potential to prevent recurrent stroke, reduce disability, and improve survival. As a result, this work is directly relevant to NINDS's mission of reducing the burden of stroke.

PI_NAMEs: KAMEL, HOOMAN ;SHETH, KEVIN NAVIN (contact)

PROGRAM_OFFICER_NAME: AFZAL, MARIAM MASHEEB

PROJECT_TERMS: Acute;Address;Adopted;Affect;antagonist;Anticoagulant therapy;Anticoagulants;Anticoagulation;Aspirin;Atrial Fibrillation;Benefits and Risks;Blinded;Blood Platelets;brain health;Brain hemorrhage;Brain Injuries;Cerebral hemisphere hemorrhage;cerebrovascular;Cessation of life;Clinical;clinical care;clinical practice;Clinical Trials;cognitive function;comparative;Confidence Intervals;Data;disability;Disease;Double-Blind Method;Electrocardiogram;Event;Exclusion;experience;Face;Fright;functional improvement;functional outcomes;functional status;Future;General Population;Guidelines;hazard;Head;heart rhythm;Hemorrhage;high risk;Hospitalization;improved;improved outcome;indexing;Ischemia;Ischemic Stroke;Knowledge;knowledge base;Lobar;Magnetic Resonance Imaging;Measures;Mission;mortality;Multicenter Studies;National Institute of Neurological Disorders and Stroke;novel;Observational Study;Oral;Outcome;Participant;patient oriented;patient population;Patient-Focused Outcomes;Patients;Phase;Physicians;Population;post stroke;prevent;Prevention;Prevention trial;primary endpoint;primary outcome;public health relevance;Quality of life;Randomized;randomized trial;randomized, clinical trials;Recommendation;Recording of previous events;Recovery;recruit;Recurrence;Risk;Safety;secondary endpoint;Severities;Site;Stroke;Stroke prevention;stroke risk;StrokeNet trials;Subarachnoid Hemorrhage;Survivors;Testing;Therapeutic Effect;thrombotic;United States National Institutes of Health;Warfarin;Work

PROJECT_TITLE: Anticoagulation in ICH Survivors for Prevention and Recovery (ASPIRE)


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Estrogen;Prevention;Women's Health Research

PHR: Project Narrative The project will investigate novel mechanisms for estrogen receptor loss and breast cancer progression, and to identify the drugs capable of blocking these adverse effects.

PI_NAMEs: LIN, FANG-TSYR ;LIN, WEEI-CHIN  (contact)

PROGRAM_OFFICER_NAME: KAI, MIHOKO

PROJECT_TERMS: 3-Dimensional;Adverse effects;Aftercare;Animal Model;Binding;Biological Markers;breast cancer diagnosis;breast cancer metastasis;Breast Cancer Patient;Breast Cancer Prevention;breast cancer progression;Breast Cancer therapy;Cell Mobility;Cells;Characteristics;Clinic;Clinical Trials;clinically relevant;Collaborations;Cultured Cells;Data;derepression;Disease;Dissociation;E-Cadherin;E2F transcription factors;Effectiveness;Endocrine;Epidermal Growth Factor Receptor;Epithelium;ESR1 gene;Estrogen receptor negative;Estrogen receptor positive;Estrogen Receptors;Event;Evolution;Exons;GATA3 gene;Genetic Transcription;Guanosine Triphosphate Phosphohydrolases;high risk;hormone therapy;improved;In Vitro;in vivo;in vivo Model;inhibitor;innovation;Intervention;Invaded;Investigation;Malignant Breast Neoplasm;Mammary Neoplasms;MCF7 cell;MDA MB 231;Mediating;Mesenchymal;migration;MMP9 gene;Modeling;Neoplasm Metastasis;new therapeutic target;novel;novel therapeutic intervention;novel therapeutics;overexpression;Pathway interactions;Patients;Pharmaceutical Preparations;pharmacologic;Pharmacologic Actions;Phenocopy;prevent;promoter;protein expression;Protein Isoforms;receptor expression;Regulation;Resistance;response;Risk;Role;Sampling;Signal Transduction;slug;small hairpin RNA;small molecule inhibitor;spheroids;Testing;therapeutic target;three dimensional cell culture;tumor;tumor microenvironment;Up-Regulation;Vimentin;Xenograft Model;Xenograft procedure

PROJECT_TITLE: 14-3-3tau drives estrogen receptor loss and breast cancer progression

STUDY_SECTION: THI

STUDY_SECTION_NAME: Tumor Host Interactions Study Section[THI]


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Epilepsy;Genetics;Human Genome;Neurodegenerative;Neurosciences

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: PROJECT NARRATIVE  Epilepsy is a serious chronic neurologic condition that affects over 50 million people worldwide, and the most common form of focal epilepsy, temporal lobe epilepsy (TLE), is frequently resistant to medical treatment resulting in significant neurologic and psychiatric morbidity. Recent research has shown that genetic mutations that arise after conception (somatic variants) may disrupt normal cellular function in the brain and cause neuropsychiatric disease. This proposal will examine the hypothesis that somatic mutations cause TLE and it will aim to identify the cell-types and gene expression changes that contribute to the development of this disease.

PI_NAMEs: KHOSHKHOO, SATTAR  (contact)

PROGRAM_OFFICER_NAME: REZAIZADEH, KAVON PAUL

PROJECT_TERMS: Address;Advisory Committees;Affect;Autopsy;Biomedical Research;Blood Vessels;Boston;BRAF gene;Brain;brain control;brain tissue;career;career development;Cell Physiology;cell type;Cells;Chronic;clinical training;comparative;Complement;Conceptions;Cortical Dysplasia;Data;deep sequencing;Development;Diagnostic;diagnostic strategy;Disease;DNA;DNA analysis;DNA Sequence Alteration;Environment;Epilepsy;Epileptogenesis;Event;Excision;experience;Fostering;FRAP1 gene;Freezing;frontal lobe;gain of function;Ganglioglioma;Gene Expression;gene panel;Genes;Genetic;Genetic Research;Genetic Transcription;genetic variant;Genomics;Goals;Hippocampus;Hospitals;Human;Human Genetics;In Situ;Individual;Institution;Lesion;Link;Magnetic Resonance Imaging;MAP Kinase Gene;MAPK Signaling Pathway Pathway;medial temporal lobe;Mediating;Medical;medical schools;Mentors;Molecular;Morbidity - disease rate;Mosaicism;mouse model;mutant;Mutation;N-Methyl-D-Aspartate Receptors;Nervous System Disorder;Neurologic;Neurology;Neurons;neuropsychiatric disorder;neurotrophic factor;novel;Operative Surgical Procedures;overexpression;Partial Epilepsies;Pathogenesis;Pathogenicity;Pathway interactions;Patients;Pediatric Hospitals;Persons;Physicians;Play;Positioning Attribute;professor;Program Development;programs;Publishing;Ras/Raf;Refractory;Reporting;Research;Research Personnel;Research Training;Resected;Resistance;Resources;RNA;RNA analysis;Rodent;Role;Scientist;Sclerosis;Seizures;Signal Transduction;single cell genomics;single cell sequencing;single nucleus RNA-sequencing;skills;Somatic Mutation;Specificity;Techniques;Temporal Lobe;Temporal Lobe Epilepsy;Tissues;Training;transcriptome;transcriptome sequencing;Trauma;tumor;United States National Institutes of Health;Variant;Woman

PROJECT_TITLE: Genetic and Cellular Mechanisms of Temporal Lobe Epilepsy

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-1 Study Section[NST-1]


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Childhood Obesity;Clinical Research;Heart Disease;Maternal Health;Nutrition;Obesity;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Physical Activity;Pregnancy;Prevention;Women's Health Research

ORG_CITY: IOWA CITY

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: PROJECT NARRATIVE There is growing evidence that maternal health and behaviors in pregnancy, such as pre-pregnancy obesity, excessive gestational weight gain, poor diet, smoking, and adverse pregnancy outcomes, are linked to fetal programming for obesity and cardiovascular disease (CVD) risk in the offspring. Yet, there is a surprising lack of research on the role of prenatal sedentary behavior, physical activity, and sleep (conceptualized together as 24-hour behavior) on offspring obesity risk and CVD risk; this is an unfortunate research gap since there is strong physiological rationale that these behaviors in pregnancy could influence offspring health and are modifiable intervention targets in pregnancy. This multi-site observational cohort study will leverage state-of- the-art, 24-hour behavior assessment in each trimester of pregnancy, collected as part of the ongoing Pregnancy 24/7 cohort study and add additional assessments of offspring growth, adiposity, and CVD risk through 24 months to inform future primordial prevention interventions to decrease the risk of offspring obesity and CVD across the lifespan.

PI_NAMEs: BARONE GIBBS, BETHANY ;WHITAKER, KARA MARIE (contact)

PROGRAM_OFFICER_NAME: DONZE, LAURIE FRIEDMAN

PROJECT_TERMS: Address;Adult;adverse pregnancy outcome;Aging;Behavior;Behavior assessment;Birth;Blood Pressure;Blood Vessels;Body mass index;Breast Feeding;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;Cause of Death;Child;Child Health;Childhood;clinically relevant;Cohort Studies;Data;Data Analyses;Development;Diet;Disease;early childhood;early onset;Enrollment;Epidemic;Fetal Growth;fetal programming;First Pregnancy Trimester;Future;gestational weight gain;Goals;Growth;Health;Home environment;Hour;Hypertension;in utero;Incidence;interest;Intervention;late life;Late pregnancy;life span;Link;Maternal Behavior;Maternal Exposure;Maternal Health;Measurement;Measures;Medical Records;Methods;Modeling;modifiable behavior;Monitor;National Heart, Lung, and Blood Institute;novel;Obesity;obesity in children;obesity risk;observational cohort study;offspring;offspring obesity;Outcome;Participant;Pattern;Persons;Physical activity;Physiologic pulse;Physiological;poor sleep;post pregnancy;postnatal;Pregnancy;Pregnancy Trimesters;Pregnant Women;prenatal;prenatal exposure;prepregnancy obesity;prevent;Prevention;preventive intervention;primary outcome;Primary Prevention;prospective;Questionnaires;Research;response;Risk;Risk Factors;Risk Reduction;Role;sedentary lifestyle;Site;Sleep;Smoking;Statistical Methods;theories;Time;Unhealthy Diet;United States;vigorous intensity;Visit;Woman

PROJECT_TITLE: Sedentary behavior, physical activity, and 24-hour behavior in pregnancy and offspring health: the Pregnancy 24/7 Offspring Study

STUDY_SECTION: LHB

STUDY_SECTION_NAME: Lifestyle and Health Behaviors Study Section[LHB]


NIH_SPENDING_CATS: Mental Health;Neurosciences

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative Higher brain functions such as learning, memory and cognition requires for brain cells to undergo plastic changes in the connectivity, i.e. synaptic plasticity, and impairments in this plasticity are thought to underlie cognitive impairment in various pathological conditions. Here, we will elucidate the mechanisms that mediate the decision between two opposing forms of synaptic plasticity, long-term potentiation (LTP) and long-term depression (LTD). These mechanisms are relevant for understanding normal neuronal information processing as well as its impairments in conditions including Angelman Syndrome, schizophrenia, and intellectual disability.

PI_NAMEs: BAYER, K. ULRICH  (contact)

PROGRAM_OFFICER_NAME: CHURN, SEVERN BORDEN

PROJECT_TERMS: Address;Affinity;Angelman Syndrome;Binding;Brain;brain cell;Ca(2+)-Calmodulin Dependent Protein Kinase;Calmodulin;calmodulin-dependent protein kinase II;Cognition;Data;dimer;FASTK Gene;Feedback;Frequencies;Funding;Glutamate Receptor;Hippocampus;Holoenzymes;Impaired cognition;Impairment;In Vitro;information processing;Intellectual functioning disability;Kinetics;Learning;Left;Long-Term Depression;Long-Term Potentiation;Mediating;Memory;Mental Depression;Molecular Computations;monomer;N-Methylaspartate;Neurons;NUP214 gene;Output;Pathologic;Perception;Phosphorylation;Physical condensation;preference;Prevention;Reaction;Regulation;Role;Schizophrenia;Signal Transduction;Speed;Structure;Synapses;Synaptic plasticity;Tail;Testing;tool;Work

PROJECT_TITLE: CaMKII Holoenzyme Mechanisms in Opposing Forms of Synaptic Plasticity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BN-G(06)]