NIH_SPENDING_CATS: Antimicrobial Resistance;Biotechnology;Clinical Research;Immunization;Infectious Diseases;Malaria;Malaria Vaccine;Pediatric;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative Vaccines offer the greatest potential tool to provide protection against malaria and to maintain gains in malaria control and ultimately move to elimination. However, a lack of understanding of how immunity naturally develops in children living in high burden areas has severely limited our ability to develop an effective malaria vaccine. The central theme of this proposal will be to improve our understanding of factors driving the development of naturally acquired immunity in Ugandan children by studying infecting parasites and the host response in detail as immunity develops.

PI_NAMEs: GREENHOUSE, BRYAN R (contact)

PROJECT_TERMS: acquired immunity;Address;Adult;Africa South of the Sahara;Age;Anti-malarials;Antibodies;Antibody Repertoire;Antibody Response;Antibody titer measurement;Antigens;Area;Automobile Driving;Biological Assay;Birth;Blood;Chemoprevention;Child;Childhood;Clinical;Clinical Data;cohort;Cohort Studies;Complex;Custom;Data;deep sequencing;Development;Disease;Drug resistance;early childhood;Epidemiology;Erythrocytes;Evaluation;experience;experimental study;Exposure to;Falciparum Malaria;Fever;Genetic;Genetic Variation;genome sequencing;Genomics;Immune response;Immunity;Immunology;improved;Individual;Infection;Insecticide Resistance;Insecticides;Intervention;Investments;Licensing;Life;Longitudinal Studies;Malaria;Malaria Vaccines;Measurement;Methods;Molecular;Natural Immunity;Outcome;Parasites;Peptides;Pharmacotherapy;Plasmodium falciparum;Positioning Attribute;Protein Array;Recording of previous events;Research;Residual state;Resistance;response;Role;Sampling;statistics;Testing;Time;tool;Uganda;Vaccines;Validation;Variant;whole genome

PROJECT_TITLE: Drivers of strain-specific and strain-transcendent antimalarial immunity in childhood

STUDY_SECTION: CRFS

STUDY_SECTION_NAME: Clinical Research and Field Studies of Infectious Diseases Study Section[CRFS]


ADMINISTERING_IC: EY

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision

ORG_CITY: GAINESVILLE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: OPHTHALMOLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: NARRATIVE Blinding diseases are some of the most devastating health concerns in the United States. This training program seeks to produce independent investigators capable of sustaining productive, innovative, independent research programs in the vision sciences. These new scientists are expected to generate discoveries in the underlying mechanisms of vision and associated pathologies, and to help develop treatments for these diseases.

PI_NAMEs: SMITH, W CLAY (contact)

PROGRAM_OFFICER_NAME: CLAYTON, EDWIN C

PROJECT_TERMS: Research Training;vision science

PROJECT_TITLE: Research Training in Vision Science


ADMINISTERING_IC: GM

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: WORCESTER

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

ORG_STATE: MA

PHR: The proposed research is relevant to public health because it will elucidate the mechanisms by which gene expression, controlled by the nervous system through TFEB, confers protection against chemical and microbial inflammation. The proposed work has great potential to accelerate the development of innovative therapies that target the Brain/TFEB axis to treat infectious and inflammatory diseases. The proposed research is relevant to the part of the NIH’s mission that pertains to developing fundamental knowledge that will help to reduce the burden of human disease.

PI_NAMEs: IRAZOQUI, JAVIER ELBIO (contact)

PROGRAM_OFFICER_NAME: ZHAO, XIAOLI

PROJECT_TERMS: Acceleration;Acetylcholine;Address;Afferent Neurons;Anatomy;Animals;Back;Behavior;Biological Models;Brain;Caenorhabditis elegans;Chemicals;Communicable Diseases;Communication;Complex;defense response;detection platform;Development;Diagnostic;Disease;Environment;Event;Future;Gene Expression;Genes;Goals;gut-brain axis;Host Defense;host-microbe interactions;Human;human disease;human model;Immune;in vivo;in vivo Model;Infection;Inflammation;Inflammatory;Innovative Therapy;insight;interest;intestinal epithelium;Intestines;Knowledge;Malignant Neoplasms;Mammals;Mediating;Metabolic syndrome;Microbe;microbial;microbiota;Mission;Molecular;mouse model;Natural Immunity;Nerve Degeneration;Nervous System;Neurodegenerative Disorders;Neurons;Organ;Organism;pathobiont;pathogen;pathogenic bacteria;Physiology;programs;Public Health;Regulation;Research;Resolution;Role;Signal Transduction;success;targeted treatment;Therapeutic;transcription factor;Translating;United States National Institutes of Health;Vision;Work

PROJECT_TITLE: Mechanisms of the gut-brain axis that regulate innate immunity


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Estrogen;Genetics;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza;Rare Diseases

ORG_CITY: BALTIMORE

ORG_DEPT: MISCELLANEOUS

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Infectious Acute respiratory distress syndrome (ARDS) causes an exuberant inflammatory disease of the lung, with limited treatment options and an unacceptably high mortality. Our group has identified new therapies for ARDS, focusing on a specialized immune cell, the regulatory T cell (Treg) with the capacity to promote resolution of lung injury in preclinical models of disease. Collectively our preliminary data in mice, cells, and humans support a model that estrogen receptor beta (ER) agonists have therapeutic effects, via Tregs, in pneumonia-induced ARDS and can promote resolution of lung injury.

PI_NAMEs: D'ALESSIO, FRANCO RAFAEL (contact);DAMICO, RACHEL L;YEGNASUBRAMANIAN, SRINIVASAN

PROGRAM_OFFICER_NAME: ESPINOZA GRANDON, INGRID CECILIA

PROJECT_TERMS: Acute;acute infection;Acute Pneumonia;Acute Respiratory Distress Syndrome;Agonist;Alveolar;alveolar epithelium;Animals;Anti-viral Response;antimicrobial resistant pathogen;Candidate Disease Gene;Cause of Death;Cell Count;Cell Physiology;Cells;Cellular biology;Clinical;Clinical Trials;COVID-19;Critical Pathways;cytokine;Data;Development;disease model;disease-causing mutation;drug resistant pathogen;Elements;Estradiol;Estrogen Receptor 2;estrogenic;Estrogens;Flow Cytometry;FOXP3 gene;GATA3 gene;Gene Expression;Gene Expression Profiling;Genetic Transcription;Goals;high dimensionality;Homeostasis;Human;Immune;Immune response;in silico;In Vitro;in vitro activity;in vivo;Infection;Inflammatory;inflammatory lung disease;Inflammatory Response;Injury;loss of function;Lung;lung injury;Macrophage;Mediating;Mediator;Modeling;Molecular;mortality;Mus;neutrophil;novel therapeutics;Outcome;pathogen;Pathway interactions;Phase;Pilot Projects;Play;Pneumonia;pneumonia model;pneumonia treatment;pre-clinical;Pre-Clinical Model;Production;programs;promoter;Proteins;Publishing;Pulmonary Inflammation;Regulation;Regulatory T-Lymphocyte;repaired;Resolution;response;RNA Helicase;Role;Signal Pathway;Signal Transduction;Streptococcus pneumoniae;Testing;Therapeutic;Therapeutic Effect;therapeutic evaluation;therapeutic target;transcription factor;Up-Regulation;Variant;Work

PROJECT_TITLE: Targeting Estrogenic pathways in Tregs to promote ARDS resolution

STUDY_SECTION: LIRR

STUDY_SECTION_NAME: Lung Injury, Repair, and Remodeling Study Section[LIRR]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Complementary and Integrative Health;Health Services;Interstitial Cystitis;Physical Activity;Physical Injury - Accidents and Adverse Effects;Prevention;Urologic Diseases;Women's Health Research

ORG_CITY: GALVESTON

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

ORG_STATE: TX

PHR: PROJECT NARRATIVE Many older women with urinary urgency and incontinence are at high risk of falling. This study will determine the feasibility of conducting a three-arm comparative effectiveness randomized trial of a behaviorally based pelvic floor muscle training (PFMT) intervention versus two recent medical management options in older women at high fall risk.

PI_NAMEs: FISHER, STEVEN R (contact)

PROGRAM_OFFICER_NAME: NELLISSERY, MAGGIE JACOB

PROJECT_TERMS: Accidents;Adherence;Adverse event;Agonist;Anti-Cholinergics;arm;Behavior Therapy;Behavioral;care seeking;Centers for Disease Control and Prevention (U.S.);Cessation of life;Characteristics;Chlorides;cholinergic;Clinic;Clinical;clinical efficacy;Clinical Research;Clinical Trials;Cognition;comparative;comparative effectiveness;comparative effectiveness trial;comparative efficacy;Data;Decision Making;design;Development;Educational Intervention;Effectiveness of Interventions;Elderly;Enrollment;Equipoise;Evaluable Disease;experience;Failure;fall injury;fall risk;falls;fear of falling;Geriatrics;Head;high risk;High Risk Woman;Home;human old age (65+);Impairment;Incontinence;Individual;Intervention;Interview;Link;Literature;Measures;Mediation;Medical;Methods;micturition urgency;multiple chronic conditions;Muscarinics;Nonpharmacologic Therapy;older adult;older women;Outcome;Overactive Bladder;Participant;patient population;Patients;Pelvic Floor Muscle;Pharmaceutical Preparations;pharmacologic;Pharmacological Treatment;Physical activity;Physical Function;physical therapist;Physicians;Pilot Projects;Prevalence;primary outcome;Productivity;programs;Quality of life;Randomized;randomized effectiveness trial;recruit;Research;Research Design;Risk Factors;risk sharing;Sampling;Screening procedure;Severities;side effect;Social isolation;Stigmatization;Structure;success;Symptoms;Syndrome;Texas;Theoretical model;Titrations;Training;Treatment Cost;treatment response;treatment risk;trial comparing;Universities;urinary;Urinary Incontinence;Variant;Visit;Woman;Work

PROJECT_TITLE: Comparative effectiveness of pelvic floor muscle training, Mirabegron, and Trospium among older women with urgency urinary incontinence and high fall risk: a feasibility randomized clinical study.

STUDY_SECTION: ICSC

STUDY_SECTION_NAME: Interdisciplinary Clinical Care in Specialty Care Settings Study Section[ICSC]


ADMINISTERING_IC: MH

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Bioengineering;Brain Disorders;Data Science;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: SANTA CRUZ

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF CALIFORNIA SANTA CRUZ

ORG_STATE: CA

PHR: PROJECT NARRATIVE Neuropsychiatric and neurodevelopmental diseases are a major burden on our health care system and also greatly reduce the quality of life for many patients. Until recently, the genetic roots of these diseases have remained obscure; SSPsyGene will change that. We propose a scalable and systematic high-tech center to coordinate SSPsyGene and its large and complex data sets to shed new light on exactly how genes cause neurological illness.

PI_NAMEs: HAUSSLER, DAVID H (contact);NOWAKOWSKI, TOMASZ

PROGRAM_OFFICER_NAME: PEVSNER, JONATHAN ABRAM

PROJECT_TERMS: Administrative Coordination;Algorithms;Alleles;Area;Atlases;Biological Assay;biomedical resource;Biotechnology;Brain;BRAIN initiative;Brain Mapping;California;cancer genome;Cells;Childhood;Clinical;ClinVar;cohort;Collaborations;Communities;complex data;computerized data processing;Consensus;Data;data format;data platform;data portal;Data Protection;data resource;Data Set;data sharing;data standards;Data Store;data submission;Databases;Disease;Effectiveness;effectiveness research;Electrophysiology (science);empowerment;Ensure;Environment;exome sequencing;experience;FAIR principles;Fast Healthcare Interoperability Resources;Funding;Generations;Genes;Genetic;genome browser;genome wide association study;Genomics;Goals;Health;health record;Healthcare;Healthcare Systems;Human;Image;Information Resources;innovation;insight;International;interoperability;knowledge base;Lead;Leadership;loss of function;Maps;Measurement;Medical Genetics;Medicare/Medicaid;meetings;Mental disorders;Metadata;model organism;Modeling;Modernization;Modification;Molecular;Monitor;National Heart, Lung, and Blood Institute;National Human Genome Research Institute;neural;Neurobiology;Neurodevelopmental Disorder;Neurologic;neuropsychiatric disorder;Neurosciences;novel;Ontology;Organoids;Patients;Persons;Phenotype;Process;Provider;Publications;Publishing;Quality of life;Records;Regenerative Medicine;Research Personnel;Research Priority;Resources;risk variant;Services;Source;Structure;success;Support System;Techniques;Technology;The Cancer Genome Atlas;Tissues;Training;Trans-Omics for Precision Medicine;Trust;United States National Institutes of Health;virtual;Vision;web portal;whole genome;Work;working group

PROJECT_TITLE: Data Resource and Administrative Coordination Center for the Scalable and Systematic Neurobiology of Psychiatric and Neurodevelopmental Disorder Risk Genes Consortium


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Genetics;Heart Disease;Hypertension;Kidney Disease;Women's Health Research

ORG_CITY: PITTSBURGH

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project Narrative This proposal will investigate the role of small non‐coding RNAs, termed microRNAs, in the regulation of sodium (Na+) transport in the distal kidney nephron. We will investigate the hypothesis that the mineralocorticoid hormone, aldosterone up-regulates the expression of specific miR clusters in the distal kidney nephron which feedback to negatively alter Na+ transport. We will test this novel function of microRNAs in Na+ homeostasis using control mice and a nephron-specific microRNA knockout mouse model that will be subjected to aldosterone stimulation and changes to renal Na+ handling will confirm that these microRNAs are acting as a negative feedback regulators of aldosterone signaling.

PI_NAMEs: BUTTERWORTH, MICHAEL B (contact)

PROGRAM_OFFICER_NAME: KETCHUM, CHRISTIAN J

PROJECT_TERMS: absorption;Address;Adrenal Glands;Aldosterone;Angiotensin I;Angiotensin II;Angiotensinogen;Angiotensins;arterial stiffness;Atrial Fibrillation;Blood Pressure;blood pressure control;blood pressure elevation;Blood Pressure Monitors;blood pressure regulation;Body Fluids;cardiovascular disorder risk;Cardiovascular system;Cell Line;Cells;collecting tubule structure;coronary fibrosis;Cortical Nephron;Cytoprotection;Data;desensitization;dietary;dietary salt;Disease;Distal;Duct (organ) structure;Electrolyte Balance;Epithelium;Equilibrium;Feedback;Female;Glucocorticoids;Heart Hypertrophy;Homeostasis;Hormones;Hour;Hyperaldosteronism;Hypertension;in vivo;Kidney;kidney cell;kidney fibrosis;Knockout Mice;Link;Messenger RNA;Metabolic syndrome;MicroRNAs;Mineralocorticoid Receptor;Mineralocorticoids;mortality;mouse model;Mus;Nature;Nephrons;novel;Nucleotides;osmotic minipump;Phosphotransferases;Physiological;Premenopause;Production;protein expression;Proteins;Regulation;Renin;Repression;Research Personnel;Resistant Hypertension;response;Risk;Role;salt intake;Serum;sex;Sex Differences;Signal Pathway;Signal Transduction;Signaling Protein;Sodium;steroid hormone;stroke risk;System;Testing;Time;tool;Untranslated RNA;Up-Regulation;Woman;women versus men

PROJECT_TITLE: Role of MicroRNAs in Kidney Sodium Regulation

STUDY_SECTION: KMBD

STUDY_SECTION_NAME: Kidney Molecular Biology and Genitourinary Organ Development[KMBD]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: HOUSTON

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: Project Narrative  After intracerebral hemorrhage, clearance of the hematoma is essential for better restoration of brain function as this cleanup process is accomplished by brain microglia and blood-derived macrophages (M, phagocytes) and during clearance of the hematoma components, M produce massive quantities of bilirubin (BrB, a yellow pigment) by converting heme from the hematoma. BrB is an antioxidant, but due to its poor water- solubility, will form intracellular precipitates when it accumulates, which alters biological membranes and DNA, leading to M dysfunction; however, BrB activates the transcription factor (aryl hydrocarbon receptor [AhR]), to enhance production of proteins essential for preventing bilirubin precipitation, as well as other proteins that benefit M involved in hematoma resolution. Therefore, we will evaluate AhR as a new target for hemorrhage therapy.

PI_NAMEs: ARONOWSKI, JAROSLAW  (contact);ZHAO, XIURONG

PROGRAM_OFFICER_NAME: DALEY, WILLIAM PATRICK

PROJECT_TERMS: ABCB1 gene;Affect;Age;Agonist;Animals;Anti-Inflammatory Agents;Antioxidants;Aryl Hydrocarbon Receptor;Bilirubin;Binding;Biological;Blood;Brain;brain cell;Brain Injuries;brain repair;cell injury;Cerebral hemisphere hemorrhage;Clinical;Cytoprotection;Cytosol;Data;DNA;Drug Metabolic Detoxication;Erythrocytes;Erythrophagocytosis;Excision;Excretory function;Extracellular Space;Functional disorder;Genes;Genetic Transcription;Glutathione S-Transferase;Health;Hematoma;Heme;heme oxygenase-1;Hemoglobin;Hemorrhage;Homeostasis;In Vitro;in vivo;Inflammation;Inflammatory;Inflammatory Response;inhibitor;injured;Injury;Knockout Mice;Macrophage;Mediating;Membrane;Microglia;Molecular;mouse model;Neurological outcome;neurological recovery;new therapeutic target;nuclear factor-erythroid 2;Nuclear Translocation;Nucleic Acids;Pathway interactions;Phagocytes;Phagocytosis;Phenotype;Pigments;Play;Precipitation;preservation;prevent;Process;Production;Proteins;Pump;Receptor Activation;Recovery;repaired;Research;Resolution;response;restoration;Role;sex;Small Interfering RNA;Solubility;Sulforaphane;Therapeutic;therapeutic target;transcription factor;water solubility

PROJECT_TITLE: Aryl hydrocarbon receptor and bilirubin as therapeutic target for ICH

STUDY_SECTION: BINP

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]


ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: PROJECT NARRATIVE A major goal of the UCI Vision Science Training Program (VSTP) is train future leaders in vision science who will advance research on the causes, diagnosis, progression and treatment of human visual impairments. Trainees will be at the forefront of discovery to ameliorate human diseases affecting the visual system.

PI_NAMEs: KISER, PHILIP DAVID;LIU, CHANG C;PALCZEWSKI, KRZYSZTOF  (contact)

PROJECT_TERMS: Training Programs;vision science

PROJECT_TITLE: Visual Sciences Training Program (VSTP)


ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: The unpredictable nature of seizures is a burden on persons with epilepsy and their caregivers. Using animal models of absence epilepsy, we propose to test new methods for a) predicting when the next seizure will occur and b) using this information to prevent seizures from occurring.

PI_NAMEs: GANGULI, SURYA ;HUGUENARD, JOHN R (contact)

PROGRAM_OFFICER_NAME: CHURN, SEVERN BORDEN

PROJECT_TERMS: Absence Epilepsy;Acute;Address;Animal Model;Animals;awake;Axon;Brain;calcium indicator;Calcium ion;Caregivers;Cells;Characteristics;Clozapine;Cortical Synchronization;Coupled;Coupling;Data;density;Detection;Diameter;Dissection;Early Diagnosis;efficacy testing;Electrodes;Electroencephalography;Electrophysiology (science);Elements;Epilepsy;epileptiform;Event;experimental study;Genetic;Image;improved;In Vitro;in vivo;in vivo two-photon imaging;Incidence;Interruption;Light;Locomotion;Machine Learning;Measures;Methods;Modeling;mortality;Motor Activity;multimodal data;multimodality;multiphoton microscopy;Mus;Nature;Neocortex;neural;neural circuit;neuronal cell body;Neurons;Noise;novel;novel strategies;novel therapeutic intervention;optogenetics;Output;Oxides;Patients;Pattern;Persons;pharmacologic;Population;prediction algorithm;predictive modeling;predictive test;Preparation;prevent;Prevention;Process;Pupil;Quality of life;Rattus;Resolution;response;Rodent Model;Role;SCN8A gene;Seizures;Sensory;sensory stimulus;Severities;Signal Transduction;Silicon;Slice;Specificity;Stimulus;Stream;Synapses;Testing;Thalamic Nuclei;Thalamic structure;Therapeutic Intervention;Time;unsupervised learning;Virus

PROJECT_TITLE: Tracking pre-seizure dynamics to predict and control seizures

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


PHR: Project Narrative Continued improvement in human health depends on the translation of fundamental knowledge to clinical settings, and the integration of approaches from several different disciplines. The Stanford MSTP embraces and promotes these goals, training physician scientists to be academic leaders for future advances in biomedical research.

PI_NAMEs: CHUA, KATRIN F. (contact)

PROGRAM_OFFICER_NAME: NELSON, SHAKIRA M

PROJECT_TERMS: Medical;Scientist;Training Programs

PROJECT_TITLE: Medical Scientist Training Program

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - A[TWD-A]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Gene Therapy;Genetics;Immunotherapy;Orphan Drug;Ovarian Cancer;Rare Diseases;Women's Health Research

ORG_CITY: AMHERST

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

ORG_STATE: NY

PHR: TCR-T Cell therapy is a promising adoptive cellular therapy modality for solid tumors, but a main barrier is the disarmament and suppression of the engineered T cells by the fibrotic tumor stroma. In the current study, novel microphysiological tumor stroma niche models will be developed to investigate the interaction between TCR-T cells and the fibrotic stromal factors with and without the combination of anti-fibrosis therapies. The study results will help the designs of anti-fibrosis therapies and future fibrosis-targeting T cells and directly benefit the ongoing clinical study on T cell therapies.

PI_NAMEs: KOYA, RICHARD C;ZHAO, RUOGANG  (contact)

PROGRAM_OFFICER_NAME: CARDONE, MARCO

PROJECT_TERMS: Adoptive Cell Transfers;Biomedical Engineering;cancer immunotherapy;Cancer Model;cancer therapy;CAR T cell therapy;Cell Physiology;Cells;Cellular Structures;Chemotactic Factors;Clinical;clinical efficacy;clinical investigation;Clinical Research;Clinical Trials;Collagen;Combined Modality Therapy;Complex;CTAG1 gene;density;design;Development;Disease;drug development;efficacy testing;engineered T cells;Extracellular Matrix;FDA approved;Fibroblasts;Fibrosis;force sensor;Funding;Future;Hematologic Neoplasms;Hematopoietic;Immune;Immunologics;Immunotherapy;improved;In Vitro;innovation;insight;Malignant neoplasm of ovary;Malignant Neoplasms;Mechanics;Medical;member;microphysiology system;Modality;Modeling;Mus;next generation;novel;ovarian neoplasm;Pathogenesis;Pharmaceutical Preparations;Physiological;Pilot Projects;Research;Scientist;Signal Transduction;Solid Neoplasm;success;T cell response;T cell therapy;T-Cell Receptor;T-Cell Receptor Therapy;T-Lymphocyte;targeted treatment;Testing;therapeutic evaluation;therapeutic target;Time;tool;Transforming Growth Factor beta;Treatment Efficacy;tumor;Tumor Antigens;Tumor-associated macrophages;tumor-immune system interactions;United States National Institutes of Health

PROJECT_TITLE: Mechanoimmunological interactions between TCR-T cells and tumor fibrotic microenvironment

STUDY_SECTION: CIC

STUDY_SECTION_NAME: Cellular Immunotherapy of Cancer Study Section[CIC]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Chronic Pain;Drug Abuse (NIDA only);Neurosciences;Opioid Misuse and Addiction;Opioids;Pain Research;Prescription Drug Misuse;Substance Misuse

ORG_CITY: TUCSON

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: PROJECT NARRATIVE  Acetaminophen (APAP) and analgesic products comprised of APAP and opioids are frequently abused and misused, a characteristic of the current prescription drug problem in the United States. Novel data from our laboratory has shown that APAP can alter expression of blood-brain barrier (BBB) tight junction proteins complexes and lead to paracellular “leak.” This grant proposal will study BBB changes in critical TJ proteins (i.e., claudin-5, occludin) expression and trafficking induced by APAP (both by itself and in in vivo models of acute/chronic pain), work that will directly impact public health in the United States by uncovering mechanisms of adverse drug events that can occur in individuals who abuse or misuse APAP and/or pharmaceutical products containing APAP.

PI_NAMEs: DAVIS, THOMAS PAUL (contact);RONALDSON, PATRICK THOMAS

PROGRAM_OFFICER_NAME: VEMURI, KIRAN R V

PROJECT_TERMS: ABCB1 gene;Acetaminophen;Acute;Acute inflammatory pain;Acute Pain;Address;Adverse drug event;Adverse event;Affect;Analgesics;Animal Experiments;antinociception;Applications Grants;Behavior;Blood - brain barrier anatomy;Blood brain barrier dysfunction;Blood Vessels;blood-brain barrier permeabilization;Brain;Carrageenan;Central Nervous System Agents;Characteristics;chronic neuropathic pain;chronic pain;clinical effect;clinically relevant;clinically significant;Cocaine;Codeine;conditioned place preference;Consumption;Data;Disease;Dose;Drug Addiction;Drug Delivery Systems;Drug Prescriptions;Effectiveness;Epidemic;experimental study;Female;Filament;Goals;Grant;Hydrocodone;improved;In Situ;in vivo;in vivo Model;Individual;inhibitor;knock-down;Knowledge;Laboratories;Ligation;liver injury;male;Measurement;Mediating;Membrane;Methamphetamine;misuse of prescription only drugs;Modeling;Molecular;Nerve;novel;occludin;Opioid;opioid exposure;opioid misuse;Oxycodone;Pain;pain model;Pathway interactions;Percocet;Perfusion;Permeability;Pharmaceutical Preparations;pharmacologic;Pharmacologic Substance;Positioning Attribute;prescription drug abuse;prescription opioid;prescription pain reliever;protein complex;protein expression;protein transport;Proteins;Public Health;receptor;response;Rewards;Role;Route;Signal Transduction;Small Interfering RNA;Spinal;spinal nerve pain;Sprague-Dawley Rats;Testing;TGF Beta Signaling Pathway;Tight Junctions;Time;Time Study;trafficking;Transforming Growth Factor beta;Transforming Growth Factors;Treatment-related toxicity;Tylenol;United States;uptake;Ventilatory Depression;Vicodin;Work

PROJECT_TITLE: Increased CNS Opioid Exposure by an Acetaminophen-Induced Blood-Brain Barrier Mechanism


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_CITY: Aurora

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative  The rete ovarii is a conserved epithelial structure that develops in parallel with the ovary during fetal life and remains closely associated with the adult ovary. This research will elucidate the precise nature and functions of the rete ovarii and its contribution to female reproductive longevity. This project will establish an integrated approach, all the way from 3D images to molecular signatures at the single cell level, which will enhance our understanding of the nature and importance of interactions between the ovary and extrinsic associated tissues, including the rete ovarii, for ovarian functions and fertility.

PI_NAMEs: MCKEY, JENNIFER C (contact)

PROGRAM_OFFICER_NAME: TAYMANS, SUSAN

PROJECT_TERMS: Ablation;Adipose tissue;Adult;Adult women;Advisory Committees;Affect;Anatomy;Biological;Biological Process;Body System;Cells;Cues;Data;design;Development;Developmental Biology;Dextrans;Diet;Endocrine;Epithelium;experimental study;Female;female fertility;Female Genital Diseases;Fertile Period;Fertility;fetal;Fetal Development;Future;Gene Expression;gene function;Genes;Genetic;genetic manipulation;Goals;Growth;Homeostasis;Hormones;Image;imaging modality;Immune;In Situ;in vivo;intraovarian;Investigation;Knowledge;Laboratories;Life;life span;Ligation;Light;Link;Location;Lymphatic;Mediating;Medulla of ovary;Meiosis;Metabolic;Metabolic Pathway;Metabolic stress;Metabolism;Methods;Microscopy;Modeling;Molecular;Molecular Profiling;mouse model;Mus;Nature;Nerve;Neuropeptides;Oocytes;Operative Surgical Procedures;Ovarian;Ovarian aging;Ovarian Follicle;ovarian reserve;Ovarian Tissue;Ovary;ovary transplantation;Ovulation;Pattern;Physiological;Play;postnatal;Primordial Follicle;Process;Productivity;Regulation;reproductive;Reproductive Biology;reproductive function;reproductive longevity;reproductive senescence;Research;response;Role;Running;Sheep;single-cell RNA sequencing;skills;Specific qualifier value;Stromal Cells;Structure;Testing;Three-Dimensional Image;Three-Dimensional Imaging;Tissues;tool;Training;transcriptomics;Viral;Virus;Visualization

PROJECT_TITLE: Functions of the rete ovarii in ovary development, adult homeostasis, and female reproductive longevity

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative This project investigates a novel physiological mechanism through which autoimmune responses in barrier tissues such as the skin are prevented. Breakdown of this mechanism could underlie autoimmune diseases, and approaches to restore it could lead to novel therapeutic strategies.

PI_NAMEs: MEMPEL, THORSTEN ROMAN (contact)

PROGRAM_OFFICER_NAME: HUDSPETH, KELLY

PROJECT_TERMS: Affinity;Anatomy;Antigens;Autoantigens;Autoimmune;Autoimmune Diseases;Autoimmune Responses;Autoimmunity;autoreactive T cell;autoreactivity;Biochemical;bisulfite sequencing;Bone Marrow;CD8-Positive T-Lymphocytes;CD8B1 gene;cell motility;Cells;Chimerism;ChIP-seq;Clone Cells;conditioning;Dendritic Cells;Development;DNA Methylation;Epigenetic Process;Epithelium;Exclusion;Exhibits;Exposure to;Failure;FRAP1 gene;Frequencies;Future;Genes;Genetic Transcription;histone modification;Histones;Homeostasis;imaging approach;Immune;imprint;in vivo;Integrins;Ligands;lymph nodes;Measures;Mediating;Memory;Mus;mutant;novel;novel therapeutic intervention;Nuclear Translocation;pathogenic virus;Pathway interactions;Peripheral;Phase;Phosphorylation;Physiological;preconditioning;Predisposition;prevent;Process;programs;prospective;Receptor Signaling;Regulatory T-Lymphocyte;Residual state;Resistance;Rest;Risk;Role;Science;Self Management;Sentinel;Signal Transduction;Site;Skin;skin disorder;skin vaccination;Specificity;T cell anergy;T cell differentiation;T memory cell;T-Cell Development;T-Cell Receptor;T-cell receptor repertoire;T-Lymphocyte;Testing;TGF Beta Signaling Pathway;Thymus Gland;Time;tissue resident memory T cell;Tissues;transcription factor;Transforming Growth Factor beta;Viral;Vitiligo;whole genome

PROJECT_TITLE: A mechanism to minimize auto-reactivity in the tissue-resident memory T cell pool

STUDY_SECTION: CMIB

STUDY_SECTION_NAME: Cellular and Molecular Immunology - B Study Section[CMIB]


NIH_SPENDING_CATS: Diabetes;Kidney Disease;Nutrition

ORG_CITY: NEW HAVEN

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative Studies proposed in this grant will examine the molecular mechanisms by which lipid induces renal cortical insulin resistance and alterations in renal cortical gluconeogenesis and mitochondrial function as well as the potential role of the sn-1,2-DAG->PKC-insulin receptorT1150 phosphorylation pathway in mediating these processes.

PI_NAMEs: SHULMAN, GERALD I (contact)

PROGRAM_OFFICER_NAME: NIHALANI, DEEPAK

PROJECT_TERMS: Acetyl Coenzyme A;Acute;Adipose tissue;awake;blood glucose regulation;Cell membrane;Chronic;Citrate (si)-Synthase;clinically relevant;Complex;controlled release;Data;Defect;Development;Diabetes Mellitus;Diacylglycerol Kinase;Diet;Diglycerides;feeding;Functional disorder;Genes;global health;Gluconeogenesis;Glucose;Glucose Clamp;glucose production;Glutaminase;Glutamine;Goals;Grant;Hepatic;hepatic gluconeogenesis;High Fat Diet;Homeostasis;Human;Hyperinsulinism;Impairment;in vivo;insight;Insulin;Insulin Receptor;insulin regulation;Insulin Resistance;insulin signaling;Kidney;kidney cortex;Knock-in Mouse;Knockout Mice;Laboratories;Lead;Lipids;Liquid Chromatography;Liver;Measures;Mediating;Metabolic;Metabolic Diseases;Methods;Mitochondria;Molecular;mouse model;Mus;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutic intervention;Obesity;Organ;oxidation;Pathogenesis;Pathway interactions;Phosphorylation;Phosphotransferases;Physiological;Play;Process;protein activation;Protein Kinase;Proto-Oncogene Proteins c-akt;Pyruvate;Pyruvate Carboxylase;pyruvate dehydrogenase;Rattus;Receptor Signaling;Regulation;Rodent;Rodent Model;Role;Seminal;Skeletal Muscle;Succinate Dehydrogenase;tandem mass spectrometry;Techniques;Testing;Time;Tracer;transcriptomics;Transgenic Organisms

PROJECT_TITLE: Mechanism of Renal Cortical Insulin Resistance

STUDY_SECTION: CSME

STUDY_SECTION_NAME: Cell Signaling and Molecular Endocrinology Study Section[CSME]


ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: PROJECT NARRATIVE The rapid pace of pediatric medical and surgical innovation combined with an increasing prevalence of infants, children, and adolescents with medical complexity has resulted in emerging clinical, operational, and ethical challenges to hospital-based pediatric care. Training of healthcare professionals in hospital-based epidemiology and outcomes research is critical to the continued excellence of pediatric inpatient care in the United States. The PHEOT program trains the next generation of physician scientists to best measure, investigate, and improve outcomes and patient safety for hospitalized children.

PI_NAMEs: BONAFIDE, CHRISTOPHER PETER;FEUDTNER, JOHN CHRIS (contact)

PROGRAM_OFFICER_NAME: MILLER, BRETT

PROJECT_TERMS: epidemiology study;Outcomes Research;Pediatric Hospitals;Training Programs

PROJECT_TITLE: Pediatric Hospital Epidemiology and Outcomes Research Training Program


NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Clinical Research;Eye Disease and Disorders of Vision;Neurosciences;Orphan Drug;Prevention;Radiation Oncology;Rare Diseases

ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: PROJECT NARRATIVE The proposed research aims at dissecting the mechanisms of vision loss in patients after treatment for uveal melanoma and developing mechanism-based treatments. It is relevant to public health because its ultimate goal is to reduce visual impairment and blindness. Thus, the proposed research is directly relevant to the NIH/NEI’s mission to support research that prevents and treats eye diseases.

PI_NAMEs: GRUMBACH, ISABELLA MARIA (contact);KARDON, RANDY H.

PROGRAM_OFFICER_NAME: GORDIYENKO, NATALIYA

PROJECT_TERMS: Adult;Aftercare;Angiography;Animal Model;Blindness;Blood capillaries;Blood flow;Blood Vessels;Brachytherapy;Choroid Melanoma;choroidal circulation;cohort;Data;density;Development;Dropout;early detection biomarkers;Early Diagnosis;Early identification;Endothelial Cells;endothelial dysfunction;Endothelium;experience;Eye;Eye diseases;Funding;Future;Genetic;Goals;Human;human data;human subject;Image;Impairment;in vivo;Infusion procedures;Injury;insight;Knowledge;Lasers;Light;Lung;Malignant Neoplasms;Measurement;Measures;Mediator;Melanoma;Methods;Mission;Mitochondria;mitochondrial dysfunction;Modality;Molecular;mouse model;Mus;Non-Invasive Detection;novel;novel therapeutics;Ocular Melanoma;Optical Coherence Tomography;Organ;Outcome;overexpression;Oxidative Stress;Pathology;Patients;Perimetry;Pilot Projects;prevent;Prevention;Production;programs;prospective;Prospective cohort;Protocols documentation;Public Health;Radiation;radiation-induced injury;Reactive Oxygen Species;real-time images;Reporting;Research;Research Support;response;Retina;retina circulation;retinal damage;Retinal Diseases;Role;Severities;standard care;Structure;Superoxides;targeted treatment;Testing;Tissues;United States National Institutes of Health;Uveal Melanoma;Vascular Diseases;vascular endothelial dysfunction;Vascular Endothelium;Vasodilation;Vision;Visual Acuity;Visual impairment

PROJECT_TITLE: Laser speckle flowgraphy as early indicator of microvasculopathy in radiation-induced vision loss

STUDY_SECTION: DPVS

STUDY_SECTION_NAME: Diseases and Pathophysiology of the Visual System Study Section[DPVS]


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Behavioral and Social Science;Chronic Pain;Clinical Research;Complementary and Integrative Health;Kidney Disease;Microbiome;Neurodegenerative;Neurosciences;Nutrition;Organ Transplantation;Pain Research;Peripheral Neuropathy;Transplantation

ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: 8. PROJECT NARRATIVE People with end-stage kidney disease may experience moderate to severe pain as a result of the inability of their kidneys to filter toxins that cause inflammation, and for many pain persists after restoration of kidney function following kidney transplantation. We all coexist with trillions of bacteria and other microbes, collectively known as the microbiome, that live in communities on and within the human body and make chemicals that reduce or exacerbate pain through the brain-gut-microbiome-axis. The goal of this study is to better understand how the communities of microbes, and the chemicals they produce that may affect pain, change after kidney transplantation, and how these changes affect pain over time in order to develop patient-centered treatments for pain by manipulating the microbiome through diet, stress reduction, and or supplementation with pre/probiotics.

PI_NAMEs: LOCKWOOD, MARK  (contact)

PROGRAM_OFFICER_NAME: CHAN, KEVIN E

PROJECT_TERMS: Address;Adult;Affect;Age;Anxiety;Bacteria;beta diversity;Biological;Biological Markers;Brain;Catabolism;chemical reduction;Chemicals;Chronic Kidney Failure;chronic pain;Clinical;Cognitive;Communities;comorbidity;Consumption;daily functioning;Data;design;Diet;Dietary Practices;Disease;Emotional;End stage renal failure;Endocrine;Endotoxins;Enterococcus;Environmental Risk Factor;experience;Fatigue;Fatty acid glycerol esters;Feces;Fiber;food consumption;Foundations;Gastrointestinal tract structure;General Population;Genes;Goals;Growth;gut microbiome;gut microbiota;health related quality of life;Hemodialysis;host-microbe interactions;Human body;Immunologics;Immunosuppression;Impairment;improved;Income;indexing;indoleacetic acid;Indoles;Inflammation;innovation;Intervention;Intestines;Investigation;Kidney;Kidney Diseases;Kidney Transplantation;Kynurenic Acid;Kynurenine;Life;Link;Longitudinal Studies;machine learning algorithm;machine learning model;Measures;Mediating;Mental Depression;Metabolic;Microbe;microbial;microbial community;microbial composition;microbiome;microbiota;microorganism;Modeling;mortality;multimodality;Neuropathy;neurotoxic;Nociception;novel;Pain;Pain intensity;Pain interference;Pain management;pain reduction;pain relief;pain score;painful neuropathy;Pathway interactions;patient oriented;patient population;Patient Self-Report;perceived stress;Persons;Phenotype;Play;post-transplant;prebiotics;prevent;Probiotics;prospective;Psychological Stress;Quinolinic Acid;Race;Recreation;Renal function;Reporting;restoration;Risk;Role;Serotonin;Serum;Signaling Molecule;social;Stress;stress reduction;sugar;Supplementation;systemic inflammatory response;Testing;Time;Toxin;transplant model;Transplant Recipients;Transplantation;treatment adherence;treatment optimization;Treatment Protocols;Tryptophan;Urea;Volatile Fatty Acids;Withdrawal

PROJECT_TITLE: The Gut Microbiome and Serum Metabolites as a Biological Mechanism Underlying Pain in Kidney Transplantation (Biome-KT)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-KUDS-W(05)]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Maternal Health;Maternal Morbidity and Mortality;Physical Injury - Accidents and Adverse Effects;Prevention;Regenerative Medicine;Rehabilitation;Urologic Diseases;Women's Health Research

ORG_CITY: LA JOLLA

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE Stress urinary incontinence is an extremely prevalent condition that affects women throughout their life, resulting in tremendous negative impact on quality of life and incurring an enormous economic burden. There is an urgent need to identify the precise tissue- and cell-level events that lead to stress urinary incontinence that will inform the development of new therapeutics. Our deployment of a novel biomaterial-based strategy in an animal model of stress urinary incontinence is expected to shift the current paradigm of delayed and compensatory treatments towards more effective preventive and therapeutic measures, improving women's health.

PI_NAMEs: ALPERIN, MARIANNA  (contact);CHRISTMAN, KAREN L

PROGRAM_OFFICER_NAME: MULLINS, CHRISTOPHER V

PROJECT_TERMS: abdominal pressure;Acute;Address;Affect;Animal Model;Animals;Atrophic;Basic Science;Biocompatible Materials;Biological Process;biomaterial development;Birth;Birth trauma;Bladder;Bladder Control;Cell Therapy;Cells;Childbirth;Chronic stress;Clinical;clinically relevant;Connective Tissue;cost;Crush Injury;Cues;Data;Deterioration;Development;Economic Burden;Epidemic;Event;Extracellular Matrix;Failure;Family suidae;Fatty acid glycerol esters;Fibrosis;Functional disorder;Functional impairment;Goals;Human;Hydrogels;Hypoxia;Immune;immune cell infiltrate;improved;in vivo evaluation;Individual;Inflammation;Injectable;Injury;injury recovery;innovation;Intervention;Intra-abdominal;Investigation;Knowledge;Life;Limb structure;long term recovery;Measures;Mechanics;Mediating;minimally invasive;Modeling;Molecular;Morbidity - disease rate;Muscle;muscle progenitor cell;muscle regeneration;Natural regeneration;nerve supply;Nervous System Trauma;neuromuscular;novel;novel therapeutics;Outcome;Pathogenesis;Pathology;Pathway interactions;Pelvis;Physiological;Pre-Clinical Model;preclinical study;preempt;pregnant;pressure;prevent;Prevention strategy;Prevention therapy;Preventive;Preventive measure;Process;Publishing;Quality of life;Rattus;Recovery;Recovery of Function;regeneration potential;regenerative;regenerative therapy;Regulation;response;Role;Saline;Sarcomeres;Skeletal Muscle;Skeletal muscle injury;Societies;stem cells;Stress Urinary Incontinence;Symptoms;Testing;Therapeutic;therapeutically effective;Time;Tissue Engineering;Tissues;translational medicine;Translational Research;Trauma;Urethra;Urethral sphincter;Urinary Incontinence;Urine;Vaginal delivery procedure;Woman;Women's Health;Work

PROJECT_TITLE: Pathways underlying recovery of injured urethral sphincter and a novel regenerative biomaterial intervention

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-R(90)]


NIH_SPENDING_CATS: Cancer;Immunotherapy;Lung;Skin Cancer

ORG_NAME: RESEARCH INST OF FOX CHASE CAN CTR

PHR: Project Narrative The major source of melanoma deaths is metastatic disease, largely due to the fact that while tumor removal  and therapies look promising for patients in the beginning, a large subset of patients will have tumor cells that  have left the primary tumor site and are in a state of ‘dormancy’ in other organs, which remain resistant to these  therapies and are unable to be detected by clinicians. We have uncovered a receptor called the MER tyrosine  kinase receptor that when expressed in dormant melanoma cells, results in their ‘reactivation’ and drives  aggressive tumor growth in the lung. We propose to study how these ‘reactivated’ melanoma cells secrete  soluble proteins into the lung to stop our immune system and other healthy cells such as fibroblasts from targeting  melanoma cells for destruction, and how this process can also lead to resistance against targeted and  immunotherapies, with the hope of finding pathways that can be targeted clinically for translational therapies  against dormant and reactivated metastatic melanoma.

PI_NAMEs: FANE, MITCHELL EDWARD (contact)

PROGRAM_OFFICER_NAME: NADEAU, CHRISTINE FRANCES

PROJECT_TERMS: Address;age related changes;aged;Aging;Antibodies;Behavior;Bioinformatics;BRAF gene;cancer cell;career development;CD8-Positive T-Lymphocytes;Cell Communication;Cell secretion;Cells;Cessation of life;Clinical;clinical translation;Communication;comparative;crosslink;Cues;Data;diagnostic tool;Disease;Distal;Doxycycline;Event;Excision;Extracellular Matrix;Family member;Fiber;Fibroblasts;Flow Cytometry;Genetic Induction;Global Change;Goals;Growth;IL2RA gene;Image;Immune;immune clearance;Immune system;Immune Targeting;Immunology;Immunosuppression;Immunotherapy;in vivo;insight;Knowledge;Left;Ligands;Liquid Chromatography;Lung;Malignant Neoplasms;Manuscripts;MEKs;Melanoma;Melanoma Cell;Metastatic Melanoma;Micrometastasis;Migration Assay;Modeling;Molecular;mortality;mouse model;Mus;Myeloid-derived suppressor cells;Nature;Neoplasm Metastasis;neoplastic cell;novel;Organ;Pathology;Pathway interactions;patient subsets;Patients;permissiveness;Phenotype;Population;Primary Neoplasm;Process;Production;Program Development;programmed cell death protein 1;Proliferating;protein expression;Protein Tyrosine Kinase;Proteins;receptor;Receptor Protein-Tyrosine Kinases;Recombinants;Regulatory T-Lymphocyte;Research Personnel;Residual Neoplasm;Resistance;Resource Development;response;Role;senescence;Signal Transduction;single-cell RNA sequencing;Site;skills;Sorting;Source;Stromal Cells;Structure of parenchyma of lung;T-Lymphocyte;tandem mass spectrometry;Techniques;therapy resistant;Thick;Tissues;TNFRSF10B gene;Training;translational therapeutics;tumor;tumor growth;tumor immunology;Tumor Tissue;tumor-immune system interactions;Up-Regulation;Visceral

PROJECT_TITLE: The role of MER/PROS1 in promoting stromal induced emergence from metastatic melanoma dormancy

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Transition to Independence Study Section (I)[NCI-I]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Coronaviruses;Emerging Infectious Diseases;Genetics;Immunization;Infectious Diseases;Vaccine Related

ORG_CITY: CLEVELAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

ORG_STATE: OH

PHR: Infection by emerging viruses, such as SARS-CoV-2, HIV, influenza, dengue and Zika viruses, poses a major challenge to global health. This study will delineate the molecular mechanisms of how infected cells detect RNA virus infection and initiate signal transduction to induce antiviral defense mechanisms. Furthermore, this study will give detailed insights into innate immune evasion by SARS-CoV-2 and other coronaviruses, which may ultimately contribute to the establishment of novel therapeutic approaches for virus-associated disorders.

PI_NAMEs: GACK, MICHAELA ULRIKE (contact)

PROGRAM_OFFICER_NAME: ARNOLD, MICHELLE MARIE

PROJECT_TERMS: 2019-nCoV;adaptive immunity;Adaptor Signaling Protein;antagonist;Anti-viral Response;antiviral immunity;Architecture;Attenuated;Binding;Biochemical;Biological;Caspase;Cell Culture System;Cells;Complex;Coronavirus;Coronavirus Infections;COVID-19 pandemic;CRISPR/Cas technology;Cytoplasm;Cytosol;cytosolic receptor;Data;Defense Mechanisms;Dengue;Dengue Virus;design;Disease;Emerging infection;emerging virus;Family;Family Picornaviridae;Flavivirus;Foundations;Gene Targeting;Genes;global health;HIV;Human;Immune;Immune Evasion;Immune response;Immune system;Immunity;In Vitro;in vivo;Infection;influenzavirus;Innate Immune Response;insight;Interferon Type I;Interferons;ISG15 gene;Knock-in Mouse;Knowledge;Laboratories;Link;Mediating;Mitochondria;Modification;Molecular;mouse model;Mus;mutant;N-terminal;Natural Immunity;novel;novel therapeutic intervention;Outcome;Papain;Pathogenesis;pathogenic virus;Peptide Hydrolases;Physiological;Proteins;receptor;Recombinants;recruit;Regulation;response;RNA;RNA Binding;RNA Virus Infections;RNA Viruses;Role;SARS-CoV-2 immunity;SARS-CoV-2 infection;SARS-CoV-2 pathogenesis;SARS-CoV-2 protease;sensor;Series;Severity of illness;Signal Transduction;Signal Transduction Pathway;ubiquitin-protein ligase;Ubiquitination;vaccine development;Vaccines;Viral;Viral Pathogenesis;viral RNA;virtual;Virus;Virus Diseases;Virus Replication;Work;ZIKA;Zika Virus

PROJECT_TITLE: Regulation of Host Innate Immunity Against Viral Infection

STUDY_SECTION: VIRA

STUDY_SECTION_NAME: Virology - A Study Section[VIRA]


NIH_SPENDING_CATS: Brain Disorders;Neurosciences;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

PHR: PROJECT NARRATIVE Precisely controlled formation of myelin on central nervous system axons is essential for motor and intellectual function. The long-term goal of this project is to understand how oligodendrocytes, which are glial cells of the central nervous system, form specific amounts of myelin on select axons during development. Completion of the project aims will substantially extend our understanding of the cellular and molecular mechanisms by which myelin membrane is produced and modified by brain activity.

PI_NAMEs: APPEL, BRUCE H (contact)

PROGRAM_OFFICER_NAME: TYLER, WILLIAM A

PROJECT_TERMS: Adult;Animals;Area;Axon;Biological Models;Brain;Brain Injuries;cell behavior;Cell Differentiation process;Cell Proliferation;Cells;Central Nervous System;Characteristics;Data;design;Development;Disease;Foundations;Genetic;Goals;Growth;Image;Immune;Injury;insight;Investigation;Learning;Membrane;Memory;Mental disorders;Messenger RNA;Microglia;migration;Molecular;Motor;Myelin;Myelin Sheath;myelination;nerve stem cell;Neuroglia;Neurons;oligodendrocyte progenitor;Oligodendroglia;pharmacologic;precursor cell;programs;Proteolipids;Research;response;single-cell RNA sequencing;stem cell fate specification;Testing;Therapeutic;Zebrafish

PROJECT_TITLE: Mechanisms of Developmental Myelination


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Genetics;Human Genome;Patient Safety;Precision Medicine

PHR: PROJECT NARRATIVE A precision approach to management of type 2 diabetes (T2D) involves using information about an individual’s genetic profile and underlying disease pathophysiology to match the right drug to the right patient. This project aims to identify the genetic predictors of response to glucagon-like peptide-1 receptor agonists (GLP-1 RAs), a relatively new but increasingly common medication for T2D, through using a genome-wide association approach in several biobank-linked electronic health records and conducting a pharmacologic drug perturbation study. If successful, the proposal will generate evidence for genotype-guided therapeutic selection and improve the understanding of drug mechanism.

PI_NAMEs: LI, JOSEPHINE H (contact)

PROGRAM_OFFICER_NAME: LI, YAN

PROJECT_TERMS: Acute;Advisory Committees;Affect;Aftercare;Agonist;Algorithms;All of Us Research Program;Area;biobank;Biochemical;Bioinformatics;Body Weight decreased;Candidate Disease Gene;Cardiovascular system;career;Clinical Pharmacology;clinical practice;clinical translation;clinical trial implementation;Clinical Trials;cohort;Collection;comparative effectiveness;Complex Genetic Trait;Complications of Diabetes Mellitus;cost;Data;Diabetes Mellitus;Diagnosis;Disease;DNA;drug efficacy;drug mechanism;Drug usage;Effectiveness;Electronic Health Record;Endocrine;Endocrinologist;expectation;experience;Exposure to;Feedback;Foundations;Functional disorder;Future;gastrointestinal;General Hospitals;Genes;Genetic;genetic analysis;genetic predictors;genetic variant;Genetic Variation;genome wide association study;genome-wide;genomic locus;Genomics;Genotype;GLP-I receptor;Glucose;glycemic control;Glycosylated hemoglobin A;Goals;Guidelines;Heterogeneity;Human;Hypoglycemia;improved;Individual;individual patient;individualized medicine;Industry;insight;Insulin;insulin secretion;International;Investigation;Jordan;Knowledge;Leadership;Life;Link;Massachusetts;Measures;Medical;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Meta-Analysis;Metabolic;Metformin;Morbidity - disease rate;mortality;Non-Insulin-Dependent Diabetes Mellitus;novel;novel drug class;Oral;Outcome;Pathway interactions;patient response;Patients;Periodicals;personalized approach;Persons;Pharmaceutical Preparations;Pharmacogenetics;pharmacologic;Phenotype;Physiological;Population;practice setting;precision medicine;predicting response;Predisposition;programs;Protocols documentation;Provider;Public Health;Recommendation;Research;Research Personnel;Resources;response;Risk;risk variant;Role;Safety;Scientific Advances and Accomplishments;side effect;skill acquisition;skills;Sulfonylurea Compounds;TCF7L2 gene;Techniques;Testing;Therapeutic;Therapeutic Agents;tool;Training;Training Programs;translational genetics;Variant;Veterans;Work

PROJECT_TITLE: Elucidating the pharmacogenetics of the response to GLP-1 receptor agonists for type 2 diabetes

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK(M1)-1-B]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Neurosciences

ORG_CITY: STORRS-MANSFIELD

ORG_NAME: UNIVERSITY OF CONNECTICUT STORRS

PHR: Perception of speech is remarkably robust even in the presence of competing background noise, yet this ability is compromised for the elderly and subjects with hearing loss. This study will explore how the auditory system is able to hear and recognize sounds in the presence of competing natural noises. This knowledge is critical to identify neural mechanisms that endow normal hearing abilities and to develop future interventions to diagnose and treat hearing loss.

PI_NAMEs: ESCABI, MONTY A (contact)

PROGRAM_OFFICER_NAME: POREMBA, AMY

PROJECT_TITLE: CRCNS: The Role of Statistical Structure for Natural Sound Recognition in Noise


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Opioid Misuse and Addiction;Opioids;Pain Research;Substance Misuse

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE The US opioid epidemic persists, with left-over pills prescribed for post-surgical pain being a major source of misuse and diversion. Building off promising pilot data, we now propose a large prospective cohort study of a novel opioid-dispensing system, comprised of a password-protected dispensing device, a smartphone app for clinical guidance, and a mail disposal procedure. This intervention is designed to reduce misuse and diversion of post-surgical opioids by promoting disposal of unused pills and reducing unnecessary consumption without compromising pain control.

PI_NAMEs: HERSHMAN, DAWN  (contact)

PROGRAM_OFFICER_NAME: NICKS, SHANNON ELIZABETH

PROJECT_TERMS: Brief Pain Inventory;Cancer Research Network;cancer surgery;Client satisfaction;Clinical;clinical practice;cohort;Computerized Medical Record;Consumption;cost;cost effective;Data;design;Devices;Enrollment;experience;Feedback;Guidelines;implementation science;improved;Intervention;Interview;Malignant Neoplasms;Mastectomy;Measures;mechanical device;Medical Waste Disposal;Methods;mobile computing;NIH Program Announcements;novel;Operating System;Operative Surgical Procedures;Opioid;opioid epidemic;opioid misuse;opioid tapering;opioid use;Pain;Pain management;Patient Self-Report;Patients;Persons;Pharmaceutical Preparations;pill;Pilot Projects;Population;Postoperative Care;Postoperative Pain;Postoperative Period;prescription monitoring program;prescription opioid;preservation;prevent;Procedures;Prospective, cohort study;Provider;public health emergency;Quality Control;Questionnaires;Random Allocation;Randomized;randomized trial;reconstruction;Reporting;Research;response;Risk;Running;Schedule;Secure;smartphone application;Source;Southwest Oncology Group;Spanish;standard of care;Structure;Surveys;System;Tablet Computer;Technology;Time;usability;Woman

PROJECT_TITLE: Efficacy of a Pill-Dispensing System to Increase Disposal of Unused Opioids and Reduce Refill Rates after Cancer Surgery


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Diabetes;Kidney Disease;Obesity;Pediatric;Precision Medicine;Prevention

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative At least 1.4 million adults in the United States have type 1 diabetes, and the incidence is increasing by 2-5% per year. Diabetic kidney disease is common in people with type 1 diabetes, can progress to kidney failure requiring dialysis or kidney transplantation, and markedly augments risks of cardiovascular disease and premature death. This project will determine the role of perturbed energetics and hypoxia in diabetic kidney disease in order to identify novel and specific targets for kidney disease prevention and treatment in type 1 diabetes.

PI_NAMEs: BJORNSTAD, PETTER ;DE BOER, IAN H (contact)

PROGRAM_OFFICER_NAME: PARSA, AFSHIN

PROJECT_TERMS: abdominal fat;absorption;adenylate kinase;Adult;Albuminuria;Biopsy;cardiovascular disorder risk;cell injury;Cessation of life;Clinical;clinical phenotype;Closure by clamp;cohort;Complex;Continuous Glucose Monitor;Cross-Sectional Studies;Data;data repository;Development;diabetes management;Diabetic Nephropathy;Dialysis procedure;Disease Outcome;disorder prevention;Dual-Energy X-Ray Absorptiometry;effective therapy;Energy Metabolism;Exhibits;follow-up;FRAP1 gene;Genetic Transcription;Glomerular Filtration Rate;Glucose Clamp;glycemic control;Goals;HIF1A gene;Hyperglycemia;Hyperinsulinism;Hypoxia;Hypoxia Inducible Factor;Impairment;improved;Incidence;Individual;Inflammation;innovation;Insulin;Insulin Resistance;insulin sensitivity;Insulin-Dependent Diabetes Mellitus;interstitial;Intra-abdominal;Iohexol;K ATPase;Kidney;kidney biopsy;Kidney Diseases;Kidney Failure;Kidney Transplantation;Knowledge;Lesion;Living Donors;living kidney donor;Magnetic Resonance Imaging;Measurement;Measures;Mediating;Metabolic;Metabolic Pathway;metabolic phenotype;Metabolism;metabolomics;Methods;Mitochondria;mitochondrial dysfunction;Modernization;modifiable risk;Molecular;Molecular Profiling;Noise;novel;Obesity;Oxygen;Participant;Pathogenesis;Pathologic;Performance;Persons;Plasma;precision medicine;premature;prevent;Publishing;renal hypoxia;Renal Plasma Flow;Residual state;Resolution;Risk;Risk Factors;Role;Signal Transduction;single-cell RNA sequencing;Sodium;stem;Structure;System;targeted treatment;Testing;Tissues;transcriptomics;Tubular formation;United States;Up-Regulation;Urine;Work;Youth

PROJECT_TITLE: Pathogenesis of kidney disease in type 1 diabetes: a modern kidney biopsy cohort

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-C(02)]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Drug Abuse (NIDA only);Emergency Care;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE Hospital visits are important opportunities to start treatment for opioid use disorder (OUD) with evidence-based medications, but this only improves outcomes if treatment is continued in the community. The present study proposes to develop and test strategies that improve transitions of care following hospitalizations for patients with OUD, which has the potential to impact public health by increasing the connection of patients to lifesaving care. The implementation mentorship, training, and research activities will inform future studies to improve both efficacy and of care for patients with OUD and set the stage for a larger-scale trial.

PI_NAMEs: LOWENSTEIN, MARGARET  (contact)

PROGRAM_OFFICER_NAME: FITZ-RANDOLPH, MARCY ESTHER

PROJECT_TERMS: acceptability and feasibility;Accident and Emergency department;acute care;addiction;Address;Affect;Ambulatory Care;Applications Grants;Area;barrier to care;Behavior;behavioral health;Buprenorphine;care delivery;Caring;Chronic;Client satisfaction;Clinical;Communication;Communities;Community Healthcare;community setting;Complex;Continuity of Patient Care;Data;design;Development;Discharge Plannings;effectiveness/implementation trial;Emergency department visit;evidence base;Evidence based treatment;experience;Face;follow-up;Future;Goals;Grant;Health Care Costs;Health Services Research;Health system;Healthcare;Homelessness;Hospitalization;Hospitals;implementation outcomes;implementation science;implementation strategy;improved;improved outcome;Individual;Intervention;intervention delivery;Interview;K-Series Research Career Programs;Lead;Leadership;Legal;Life;Link;Literature;Manuscripts;Maps;Medical;medication for opioid use disorder;Medicine;Mental Health;Mentored Patient-Oriented Research Career Development Award;Mentored Research Scientist Development Award;Mentorship;Methods;Modeling;Morbidity - disease rate;mortality;National Institute of Drug Abuse;non-opioid analgesic;Opioid;opioid epidemic;opioid use disorder;Outcome;Outcome Measure;Outpatients;Overdose;Patient Care;Patient Discharge;patient engagement;patient-level barriers;Patients;peer support;Persons;Pharmaceutical Preparations;Philadelphia;physical conditioning;Physicians;pilot test;pilot trial;Planning Theory;primary outcome;programs;Provider;provider-level barriers;Public Health;Randomized;Randomized, Controlled Trials;Research;Research Activity;Research Personnel;Sampling;secondary outcome;Services;skills;social;social stigma;Structure;substance use;Substance Use Disorder;System;system-level barriers;Testing;theories;Touch sensation;Training;Training Activity;Transportation;treatment as usual;Treatment outcome;Visit;Writing

PROJECT_TITLE: Improving transitions of care for hospitalized patients with opioid use disorder

STUDY_SECTION: ODHS

STUDY_SECTION_NAME: Organization and Delivery of Health Services Study Section[ODHS]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Palliative Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

PHR: Project Narrative Racial and ethnic minorities are more likely to experience high intensity, non-beneficial, burdensome and expensive care at end-of-life despite the fact that the majority of these patients prefer to die at home. The roles of perceived discrimination and lack of trust and how these factors affect communication and decision- making around the care one receives at the end of life are not understood. Understanding these associations will contribute important knowledge toward the development of interventions to improve communication, patient-reported outcomes, and goal-concordant care in patients who endorse experiencing perceived healthcare discrimination.

PI_NAMEs: BROWN, CRYSTAL ELIZABETH (contact)

PROGRAM_OFFICER_NAME: WHITE, DOLLY PENN

PROJECT_TERMS: Acute;Admission activity;Advance Care Planning;Affect;Behavior;Cardiopulmonary Resuscitation;care outcomes;career development;Caring;Chronic;Clinical Research;cohort;collaborative environment;Communication;Critical Care;Data;Decision Making;design;Development Plans;Disadvantaged;Discrimination;Disparity;Distress;education resources;empowerment;end of life;end of life care;Environment;ethnic minority;Ethnic Origin;Event;experience;feasibility testing;Funding;Goals;Health Care Costs;health care service utilization;health difference;health disparity;Health Professional;Health system;Healthcare;Home;Hospitalization;Hospitals;implicit bias;improved;Incidence;Individual;Inequity;insight;Institute of Medicine (U.S.);Intensive Care Units;Intervention;intervention refinement;Intervention Studies;Intervention Trial;Interview;Knowledge;Life;Lung;marginalization;Measures;Mediating;Medicine;member;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Methodology;Methods;Minority;novel;Outcome;Palliative Care;patient oriented;Patient Outcomes Assessments;patient population;patient subsets;patient-clinician communication;Patient-Focused Outcomes;Patients;perceived discrimination;Physicians;preference;Process;promote resilience;Prospective cohort;Prospective Studies;provider communication;Public Health Schools;Publications;Qualitative Research;Quality of life;Race;racial difference;racial disparity;racial health disparity;racial minority;randomized trial;Records;Religious Belief;Reporting;Research;Research Methodology;Research Personnel;Research Training;resilience;Resources;Retrospective Studies;Role;Scientist;shared decision making;skills;Sleep;social epidemiology;social health determinants;socioeconomic disadvantage;Socioeconomic Status;Stigmatization;stress management;Structure;success;Symptom Burden;Testing;theories;therapy development;Time;Training;translational health science;Trust;Universities;Washington;Work

PROJECT_TITLE: Racial inequities in end-of-life healthcare: how perceived discrimination affects communication and decision-making during serious illness


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Rural Health;Social Determinants of Health

ORG_CITY: MORGANTOWN

ORG_NAME: WEST VIRGINIA UNIVERSITY

ORG_STATE: WV

PHR: PROJECT NARRATIVE At risk youth (ARY) are those who are at risk of suicide and self-harm with suicide being the second highest cause of death in adolescents. Little is known about the experiences and needs of parents of this population of vulnerable youth. Parent support is recognized as an important factor in protecting ARY from self-harm and suicide, but there are few evidence-based support programs for parents of ARY. This study will survey a cross-section of parents about their experiences and will develop an online intervention that connects them with other parents for mentored peer support. By assessing feasibility and acceptability of the new parent support intervention, this work will inform future research aimed at improving health outcomes for ARY.

PI_NAMEs: KIDD, KACIE  (contact)

PROGRAM_OFFICER_NAME: POPKIN, RONNA

PROJECT_TERMS: acceptability and feasibility;Age;Appalachian Region;Birth;career;career development;Caring;Child;Childhood;cisgender;Clinical Trials;Collaborations;Communities;community engaged intervention;comparison control;Cross-Sectional Studies;Data;design;Development;Development Plans;Discrimination;Educational workshop;effectiveness evaluation;empowerment;Ethnic Origin;evidence base;experience;Face;Faith;Family;feasibility trial;Feeling suicidal;Foundations;Fright;Future;Gender;gender affirmation;gender diverse;Gender Identity;gender minority group;geographic barrier;Geography;Goals;Growth;Health;health equity;Health equity research;health inequalities;Health Personnel;improved;Individual;insight;Intervention;intervention effect;intervention mapping;Interview;Leadership;leadership development;Literature;marginalization;Measures;Medical;Mental Depression;Mental Health;Mentored Patient-Oriented Research Career Development Award;Methods;Modeling;National Institute of Child Health and Human Development;online intervention;online resource;Outcome;parenting intervention;Parents;patient population;pediatric patients;peer;peer coaching;peer support;perceived discrimination;Persons;pilot test;Population;Populations at Risk;pressure;Process;programs;Qualitative Research;Race;racial diversity;Randomized;randomized, clinical trials;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;recruit;Research;Research Personnel;Research Priority;rural area;rurality;Sampling;sex assigned;sexual minority group;Shapes;social;social stigma;stakeholder perspectives;Structure;success;Support Groups;support network;Support System;Surveys;therapy design;therapy development;Training;transgender;United States;urban area;usability;user centered design;Vulnerable Populations;web site;Work;Youth

PROJECT_TITLE: Development and Feasibility Trial of Online Peer Support for Parents of Gender Diverse Youth

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Health, Behavior, and Context Study Section[CHHD-M]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Prevention

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

PHR: PROJECT NARRATIVE The blood contains free-ﬂoating DNA from cells throughout the body, and when cancer is present, some of this free-ﬂoating DNA comes from cancer cells. This makes it possible to detect cancer from a routine blood draw, however, advanced statistical techniques are needed since this requires the detection of weak signals in large quantities of complex data. The purpose of this project is to develop statistical methods and software tools for this task, with the goal of enabling accurate and noninvasive early cancer screening.

PI_NAMEs: MILLER, JEFFREY WAYNE (contact)

PROGRAM_OFFICER_NAME: CHEN, HUANN-SHENG

PROJECT_TERMS: Algorithms;Bayesian Modeling;Benign;Bioinformatics;Biological;Blood;Blood Circulation;Cancer Biology;cancer cell;cancer classification;Cancer Detection;cancer genome;cancer genomics;cancer type;cell free DNA;cell repository;Cells;Cessation of life;Characteristics;Classification;Collection;Complex;complex data;Computer software;Data;Databases;Detection;Diploidy;Disadvantaged;DNA;DNA analysis;DNA sequencing;Documentation;driver mutation;dynamic system;Early Diagnosis;Early treatment;Exhibits;experience;flexibility;GENIE;Genome;genome sequencing;genome-wide;Genomics;Germ Lines;Goals;Health Policy;high standard;Learning;Malignant Neoplasms;Methodology;Methods;Modeling;Mutation;Mutation Detection;Noise;Non-Invasive Detection;novel;open source;Performance;Plasma;Plasma Cells;Positioning Attribute;Process;Psychological reinforcement;Recommendation;Reproducibility;Sampling;screening;Screening for cancer;Sensitivity and Specificity;signal processing;Signal Transduction;software development;Software Tools;sound;Specific qualifier value;Statistical Methods;Statistical Models;Structure;Survival Rate;System;Techniques;Technology;Testing;The Cancer Genome Atlas;tool;transcriptome sequencing;tumor;tumor DNA;Tumor-Derived;user-friendly;Work

PROJECT_TITLE: Statistical methods for cancer genomics and cell-free DNA analysis

STUDY_SECTION: BMRD

STUDY_SECTION_NAME: Biostatistical Methods and Research Design Study Section[BMRD]


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Immunization;Immunotherapy;Infectious Diseases;Kidney Disease;Organ Transplantation;Prevention;Transplantation

ORG_CITY: DURHAM

ORG_DEPT: SURGERY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PUBLIC HEALTH RELEVANCE / PROJECT NARRATIVE End stage renal failure represents a massive health care problem for the United States, affecting 650,000 Americans every year, and having a mortality associated with dialysis of 65% within 5 years. $42 billion is spent annually for hemodialysis. Kidney transplantation dramatically reduces the cost of caring for such patients and improves their lifespan. Improving the outcomes of kidney transplantation and prolonging the survival of transplanted kidneys and patients is a major public health goal.

PI_NAMEs: KNECHTLE, STUART JOHNSTON (contact)

PROGRAM_OFFICER_NAME: HAYES, DEBORAH

PROJECT_TERMS: Affect;Allogenic;Allografting;American;Antibodies;Antibody Therapy;antibody-mediated rejection;Antibody-Producing Cells;Arteritis;B cell therapy;B-Cell Activation;B-Lymphocytes;Binding;Biological Assay;Biopsy;care costs;Cell Communication;Cell Compartmentation;Cell Physiology;Cells;Chronic;Clinical;Cluster Analysis;comparison control;Conduct Clinical Trials;Controlled Study;Cytomegalovirus;Data;deep learning;desensitization;Diagnosis;Dialysis procedure;digital;digital imaging;donor-specific antibody;effective therapy;End stage renal failure;Ensure;Ethics;experience;Failure;Graft Survival;Half-Life;health goals;Healthcare;Heart Transplantation;Hemodialysis;Histologic;Human;human data;Image Analysis;Immune;Immune system;Immune Targeting;Immunity;Immunologics;improved;improved outcome;Infection;infection risk;Inflammation;Injury;interstitial;Intervention;Intervention Studies;Intravenous Immunoglobulins;Investigational Therapies;Isoantibodies;Kidney;kidney biopsy;Kidney Transplantation;Level of Evidence;Life;life span;Lung Transplantation;Lymphocyte Activation;machine learning algorithm;Malignant Neoplasms;Measures;Mediating;Memory;Memory B-Lymphocyte;Methods;Modeling;Monitor;mortality;nonhuman primate;novel;Organ Donor;Organ Transplantation;Outcome;pathogen;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;Phase;Phase I/II Clinical Trial;Plasma Cells;Plasmablast;Plasmapheresis;Population;post-transplant;predict clinical outcome;predicting response;Predisposition;prevent;Prevention;Process;Prognosis;prospective;Proteasome Inhibition;Proteasome Inhibitor;Proteinuria;Public Health;public health relevance;Randomized;Reaction;Regimen;Renal function;Resistance;response;restoration;retransplantation;Risk;Risk Assessment;rituximab;Safety;Solid;Standardization;Structure of germinal center of lymph node;Surrogate Markers;System;T-Lymphocyte;targeted treatment;Testing;Therapeutic Uses;Time;tool;Transplant Recipients;Transplantation;treatment comparison;Treatment Efficacy;treatment response;Tubular formation;United States;Visual;whole slide imaging

PROJECT_TITLE: Targeting the B Cell Response to Treat Antibody-Mediated Rejection


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Neurosciences;Opioid Misuse and Addiction;Opioids;Substance Misuse

PHR: Project Narrative: In 2020, over 70,000 people died from opioid overdoses, and aversive conditions are a key contributor to opioid use and cravings. While the context that opioid use occurs in perpetuating use, the neural basis of contextual memory processing with opioids is poorly understood due to a lack of understanding of the underlying neurobiology. The goal of this proposal is to dissect the dynamics of two key molecules dopamine and norepinephrine in the dorsal hippocampus providing new insights to mechanisms that regulate opiate abuse disorders.

PI_NAMEs: MATARASSO, AVI KEFIR (contact)

PROGRAM_OFFICER_NAME: FALCON-MORALES, EDGARDO

PROJECT_TERMS: Address;Adult;Affect;Agonist;alpha 2 agonist;American;Anatomy;antagonist;Attenuated;Aversive Stimulus;Behavior;behavioral pharmacology;biological adaptation to stress;career development;Clonidine;Clustered Regularly Interspaced Short Palindromic Repeats;Color;Computer Analysis;conditioned place preference;conditioning;craving;Cues;Data;designer receptors exclusively activated by designer drugs;Development Plans;Disease;Dopamine;Dopamine-beta-monooxygenase;dopaminergic neuron;Dorsal;drug craving;Drug usage;Environmental Risk Factor;Enzymes;ex vivo imaging;experimental study;Exposure to;extracellular;Fiber;Fluorescence;gene editing technology;Genes;Genetic;Goals;Hippocampus;Image;In Vitro;in vivo;Individual;inhibitor;insight;knock-down;Learning;locus ceruleus structure;long term memory;Measures;Mediating;Mediation;Memory;memory acquisition;memory process;Mentors;monoamine;Morphine;Mus;Naloxone;nerve supply;neural;Neurobiology;neuronal cell body;Neurons;Neuropharmacology;neuroregulation;neurotransmission;noradrenergic;Norepinephrine;novel;Opiate Addiction;Opioid;opioid abuse;opioid overdose;opioid use;opioid use disorder;optical imaging;Optics;optogenetics;Overdose;Pathologic;Pattern;Persons;Pharmaceutical Preparations;pharmacologic;Pharmacology;Photometry;Physiological;Positioning Attribute;preference;Process;Production;Property;Quinpirole;Raclopride;reboxetine;receptor;Recreation;redshift;Relapse;Reporting;Research Personnel;Resolution;response;reward processing;Rewards;sensor;Series;Signal Transduction;Site;Source;spatial memory;spatiotemporal;Stress;stress reactivity;substance use;Substance Use Disorder;Synaptic plasticity;Testing;Training;two-photon;Ventral Tegmental Area;Viral

PROJECT_TITLE: Norepinephrine and dopamine dynamics during conditioned place preference and aversion in dorsal hippocampus


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Diabetes;Digestive Diseases;Liver Disease;Nutrition;Obesity

ORG_CITY: BALTIMORE

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: The metabolism, storage and flux of lipids in the liver plays a central role in starvation, diet-induced obesity, diabetes and Nonalcoholic Steatohepatitis (NASH) among others, however, the mechanisms governing the shift from normal metabolic physiology to pathophysiology are poorly understood, particularly with respect to the role of lipid metabolism. Our overall hypothesis is that cellular lipid catabolism represents not only a critical metabolic endpoint in the liver, but also serves as an important signaling node in nutrient sensing that is regulated at multiple steps during the oxidation of fatty acids. Defining this communication and better understanding hepatic lipid metabolism in general may lead to novel therapeutic interventions for obesity, diabetes and NASH.

PI_NAMEs: WOLFGANG, MICHAEL J. (contact)

PROGRAM_OFFICER_NAME: LIANG, HANYU

PROJECT_TERMS: Acetylation;Adipocytes;Affect;Biochemical;Carnitine Palmitoyltransferase I;Catabolism;Code;Communication;Coupling;Data;detection of nutrient;Diabetes Mellitus;diet-induced obesity;Energy Metabolism;Equilibrium;Exhibits;Fasting;Fatty acid glycerol esters;fatty acid metabolism;fatty acid oxidation;Fatty Acids;Fatty Liver;feeding;Functional disorder;Gene Expression;Genetic Transcription;Gluconeogenesis;Goals;Hepatic;Hepatocyte;High Fat Diet;Histone Acetylation;Hydrolysis;Incidence;Inflammation;ketogenesis;Knockout Mice;Lipase;lipid metabolism;Lipids;Lipoproteins;Liver;liver metabolism;long chain fatty acid;Lysine;Metabolic;Metabolic stress;Metabolic syndrome;Metabolism;Mitochondria;Modeling;molecular phenotype;mouse model;Mus;nonalcoholic steatohepatitis;novel therapeutic intervention;Obesity;obesity treatment;oxidation;Oxidative Stress;Pathogenesis;Pathology;Pathway interactions;Phenotype;Physiology;Play;PPAR alpha;Process;Proteins;Proteomics;Regulation;response;Role;Route;Signal Transduction;Starvation;Triglyceride Metabolism;Triglycerides;uptake

PROJECT_TITLE: Coordination of hepatic fatty acid metabolism

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


NIH_SPENDING_CATS: Clinical Research;HIV/AIDS;Infectious Diseases;Mental Health;Women's Health Research

ORG_DEPT: VETERINARY SCIENCES

PHR: NARRATIVE The proposed research is relevant to public health because it focuses on understanding the size, stability and sex-based differences of the myeloid (monocyte and macrophage) reservoir in HIV. Ultimately, this proposal will help to determine if HIV establishes true latency in cells of myeloid origin, and whether this cellular reservoir has the potential to derail T cell focused cure-based efforts in HIV. Thus, the proposed research is relevant to the part of the NIH's mission that is focused on research to find a cure for HIV.

PI_NAMEs: VEENHUIS, REBECCA TERILLI (contact)

PROGRAM_OFFICER_NAME: RAO, VASUDEV RAMACHANDRA

PROJECT_TERMS: Address;Animals;Biological Assay;Blood;Brain;Cell Compartmentation;Cells;Central Nervous System Diseases;cohort;Competence;Data;Development;DNA;Female;Goals;HIV;HIV Infections;Human;Immune response;Individual;Infection;innovation;insight;Knowledge;Macaca;Macrophage;male;Measurable;Measures;men;Methods;Mission;Modeling;monocyte;Myelogenous;novel;Persons;Positioning Attribute;Public Health;Publishing;Reporting;Reproducibility;Research;Research Proposals;Role;Sampling;sex;sex as a biological variable;Sex Differences;SIV;Standardization;T-Lymphocyte;Techniques;Testing;Therapeutic;Tissues;United States National Institutes of Health;Urethra;Viral;Viral Genome;Viral reservoir;Virus;Virus Diseases;Woman;women versus men;Work

PROJECT_TITLE: Defining sex-based differences in the replication-competent myeloid reservoir in virally suppressed people with HIV and SIV-infected ART-suppressed macaques


ORG_CITY: ATLANTA

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Narrative Resistance to treatment and lack of targeted treatment options for KRAS mutations are two major clinical challenges in lung cancer therapy. A common link to these two problems is the activation of Mcl-1, a major antiapoptotic protein that is overexpressed in human lung cancer. Studies in this project will develop a novel Mcl-1 inhibitor with the goal of overcoming treatment resistance and treating lung cancer with KRAS mutations, which will have substantial impact for a large subset of patients with lung cancer.

PI_NAMEs: DENG, XINGMING  (contact)

PROGRAM_OFFICER_NAME: COVELL, DAVID G

PROJECT_TERMS: Animal Cancer Model;anti-cancer;anti-PD-1/PD-L1;anti-PD-L1;anti-PD-L1 therapy;Antineoplastic Agents;Apoptotic;Attenuated;Biological;BRCA mutations;cancer cell;Cancer cell line;Cancer Etiology;Cancer Model;cancer therapy;Clinical;Combined Modality Therapy;Data;Development;DNA biosynthesis;DNA Double Strand Break;DNA Repair;DNA Repair Pathway;DNA Sequence Alteration;Down-Regulation;Family member;FDA approved;Genetic Engineering;Goals;Growth;homologous recombination;homologous recombination deficiency;Human;Immunotherapy;improved;In Vitro;in vivo;inhibitor;KRAS2 gene;Link;lung cancer cell;Malignant neoplasm of lung;Malignant Neoplasms;MAPK3 gene;MCL1 gene;Mediating;MEKs;mortality;mutant;Mutation;new therapeutic target;Non-Small-Cell Lung Carcinoma;novel;objective response rate;Oncogenic;Outcome;overexpression;Pathway interactions;patient subsets;Patients;PD-1 blockade;PD-1 inhibitors;Phosphorylation;Phosphorylation Site;PI3K/AKT;Play;Poly(ADP-ribose) Polymerase Inhibitor;potency testing;Prognosis;Prognostic Marker;programmed cell death ligand 1;Proteins;radioresistant;refractory cancer;replication stress;Reporting;Resistance;Resistance development;Role;Signal Transduction;small molecule;STK11 gene;Subgroup;survival outcome;synergism;targeted treatment;Therapeutic;Therapeutic Intervention;therapeutic target;therapy resistant;TP53 gene;tumor;tumor growth;Tumor Tissue;Up-Regulation;Xenograft procedure

PROJECT_TITLE: Modulation of Mcl-1 for Treatment of Lung Cancer

STUDY_SECTION: DT

STUDY_SECTION_NAME: Developmental Therapeutics Study Section[DT]


ADMINISTERING_IC: ES

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Physical Injury - Accidents and Adverse Effects

ORG_CITY: ANAHEIM

ORG_NAME: LEBRUN LABS, LLC

PHR: Narrative Currently, there are no accurate nonanimal tests to identify consumer products and chemicals that require labeling to advise users to wear protective eyewear and avoid eye contact due to the threat of serious eye damage. The purpose of this application is to further develop and commercialize a new nonanimal test — the in vitro depth of injury eye irritation test (IVD EIT) — to identify this class of ocular irritants and thereby allow for adequate labeling that will advise and inform users about product safety as well as comply with new laws preventing or limiting the use of animals that have been historically used for this type of routine safety testing. 1

PI_NAMEs: LEBRUN, STEWART  (contact)

PROGRAM_OFFICER_NAME: RAVICHANDRAN, LINGAMANAIDU V

PROJECT_TERMS: Address;Animal Sources;Animal Testing;Animals;Area;Benchmarking;Biological Assay;Biological Markers;California;Categories;Cell Death;Cell Survival;Chemicals;Classification;Code;commercialization;consumer product;Cornea;Corrosives;Dangerousness;Data;Detection;Development;Diagnostic Reagent Kits;Dose;Ensure;European Union;Eye;Eye Injuries;Feasibility Studies;Felis catus;Food;Future;Generations;Goals;Grant;Hazardous Chemicals;Hour;improved;In Vitro;in vitro testing;in vivo;Incubated;Industry;Irritants;irritation;Label;Laws;Liquid substance;manufacture;Manufacturer;Measures;Methods;Oryctolagus cuniculus;Performance;Phase;phase 1 study;predictive modeling;Preparation;prevent;Procedures;Process;Product Labeling;Protocols documentation;Refrigeration;Research;retinal toxicity;Safety;safety testing;Sampling;Sensitivity and Specificity;Services;Small Business Innovation Research Grant;Solid;Specificity;Standardization;Statutes and Laws;success;Surface;surfactant;Testing;timeline;tool;United States;validation studies

PROJECT_TITLE: IVD EIT a Nonanimal Kit and Service for the Detection of Ocular Irritants: Phase II

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-NV-M(12)B]


ORG_CITY: ANN ARBOR

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Narrative The pattern of release of a hormone, gonadotropin-releasing hormone (GnRH), is critical for fertility. We are studying how this pattern is generated and how the timing is altered. This information can be used to help treat infertility.

PI_NAMEs: MOENTER, SUZANNE M (contact)

PROGRAM_OFFICER_NAME: RAVINDRANATH, NEELAKANTA

PROJECT_TERMS: Action Potentials;Affect;Afferent Neurons;Animal Model;autocrine;base;bone;Calcium;Cardiovascular system;Castration;Cell membrane;Cells;Central Nervous System;Characteristics;Closure by clamp;Communication;Couples;Data;Development;Dynorphins;Electrophysiology (science);Elements;Endocannabinoids;Excision;extracellular;Failure;Feedback;Female;Fertility;Fire - disasters;Frequencies;gamma-Aminobutyric Acid;Generations;genetic approach;Glutamates;Goals;Gonadal Steroid Hormones;Gonadotropin Hormone Releasing Hormone;Grant;Health;Hormonal;Hormones;Hypothalamic structure;Image;in silico;Individual;individual variation;Infertility;infertility treatment;interest;KISS1 gene;Knowledge;Link;male;mathematical model;Mathematics;Measures;median eminence;Membrane Potentials;Metabolism;Methods;Modeling;Molecular;Monitor;Mus;Neuroglia;Neurokinin B;Neurons;Neuropeptides;Neurosecretory Systems;Output;paracrine;Pattern;Periodicity;pharmacologic;Physiologic pulse;Pituitary Gland;Poisoning;Population;Potassium;Preoptic Areas;Process;Production;Property;Prostaglandins;Proteins;Reporter;Reproduction;reproductive;Reproductive Health;Reproductive system;response;Role;sex;Sex Differences;stem;Steroids;Structure of nucleus infundibularis hypothalami;substance use;Synapses;Synaptic Transmission;System;Testing;therapy development;Time;Transgenic Mice;Vertebrates;voltage;Whole-Cell Recordings;Work

PROJECT_TITLE: Cellular and molecular bases for rhythmic GnRH release


ORG_CITY: PARKTOWN

ORG_COUNTRY: SOUTH AFRICA

ORG_FIPS: SF

ORG_NAME: WITS HEALTH CONSORTIUM (PTY), LTD

PHR: Project Narrative Universal Test-and-Treat (UTT) represents the world’s best chance to end the HIV epidemic; yet research on UTT impact in South Africa is limited. We constructed a National HIV Cohort from the complete laboratory records of South Africa’s HIV treatment program, covering over 4000 facilities. Integrating this cohort with treatment monitoring data, we will evaluate the national impact of UTT and identify where in the UTT care cascade patients are lost to follow-up, in order to guide the next phase of South Africa’s HIV response.

PI_NAMEs: BOR, JACOB ;ONOYA, DORINA  (contact)

PROGRAM_OFFICER_NAME: HUEBNER, ROBIN E

PROJECT_TERMS: Africa;antiretroviral therapy;Boston;care seeking;Caring;case finding;CD4 Lymphocyte Count;Clinic;Clinic Visits;Clinical;Clinical Trials;cohort;Collaborations;Complement;Country;Data;Databases;design;Diagnosis;Effectiveness;Electronics;Eligibility Determination;Epidemic;Evaluation;Event;follow-up;Future;Health;HIV;individual patient;innovation;Interruption;Intervention;Laboratories;Link;migration;Monitor;novel;patient retention;Patients;Pattern;Persons;Pharmaceutical Preparations;Phase;Policies;Population Surveillance;Predictive Value;programs;Public Sector;Recording of previous events;Records;Research;response;Series;Services;South Africa;study population;System;Testing;Time;treatment program;Universities;Update;uptake;Viral;Viral Load result

PROJECT_TITLE: Evaluating UTT with a National HIV Cohort to Optimize South Africa's HIV Response (ENCORE)


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Mental Health;Neurosciences;Opioid Misuse and Addiction;Opioids;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prescription Drug Misuse;Preterm, Low Birth Weight and Health of the Newborn;Substance Misuse;Women's Health Research

ORG_CITY: BOSTON

ORG_NAME: TUFTS UNIVERSITY BOSTON

ORG_STATE: MA

PHR: The use and abuse of prescription opioids in females of reproductive age has dramatically increased over the past two decades. One consequence of this escalated use has been an upsurge in the number of babies born with opioids in their bloodstream, many of whom develop neonatal opioid withdrawal syndrome. The goals of the current set of studies are to address this public health issue using a preclinical model of oxycodone self-administration in female rats which will allow us to investigate neurodevelopmental modifications and adult outcomes associated with maternal opioid intake.

PI_NAMEs: BYRNES, ELIZABETH M (contact)

PROGRAM_OFFICER_NAME: WU, DA-YU

PROJECT_TERMS: Abstinence;abuse liability;addiction liability;Address;Adolescence;Adult;Adult Children;Age;Animal Model;Animals;Behavioral;Biological;Biological Availability;Blood Circulation;Body Weight;Body Weights and Measures;Brain region;Buprenorphine;Child;Circulation;Clinical;clinically relevant;Conceptions;Data;Development;Dose;Drug Prescriptions;early pregnancy;Epigenetic Process;Event;experience;experimental study;Female;fetal;fetal opioid exposure;Genetic Transcription;Glucocorticoids;Goals;improved;Impulsive Behavior;Infant;Intake;intergenerational;Intravenous;intravenous administration;Literature;maternal opioid use;Measures;Mediating;Metabolism;Methadone;Methyl-CpG-Binding Protein 2;Modeling;Modification;Neonatal;Neonatal Abstinence Syndrome;neonatal outcome;neurodevelopment;neurodevelopmental effect;offspring;Opiate Addiction;Opioid;opioid abuse;opioid exposure;opioid misuse;Opioid replacement therapy;opioid use;opioid use disorder;opioid use in pregnancy;Oral;Outcome;Oxycodone;oxycodone self-administration;Pattern;Pharmaceutical Preparations;postnatal;postnatal development;postnatal period;pre-clinical;Pre-Clinical Model;Pregnancy;pregnant;prenatal;prescription opioid;prescription opioid abuse;Public Health;Qualifying;Rattus;reproductive;Reproductive Biology;response;Risk;Self Administration;Severities;sex;species difference;Standardization;Stress;Substance abuse problem;Substance Use Disorder;symptom treatment;Symptoms;Testing;Treatment Protocols;Ultrasonics;vocalization;Weight Gain;Withdrawal;Woman;Work

PROJECT_TITLE: Oxycodone, Neonatal Opioid Withdrawal Syndrome, and Adult Abuse Liability

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: FARMINGTON

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT

PHR: PROJECT NARRATIVE Since the rapid drop in cost for genome sequencing, the field of genomics has experienced a bottleneck in computationally trained scientists capable of interpreting and transforming this data into actionable information to improve human health. We propose a new training program, the UConn Health/JAX-GM Genomic Sciences Training Program, to help fill this gap and provide pre- doctoral scientists with the tools they need to accomplish this goal.

PI_NAMEs: GRAVELEY, BRENTON R. (contact);LEE, CHARLES

PROGRAM_OFFICER_NAME: HERNANDEZ-RAMON, ELENA ESTELA

PROJECT_TERMS: genome sciences;Training Programs

PROJECT_TITLE: The UConn/JAX-GM Training Program in Genomic Science


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: DALLAS

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: Noroviruses are a leading cause of gastroenteritis worldwide, yet there are no approved therapies or vaccines available. This proposal seeks to understand how a class of antiviral restriction factors regulate the ability of noroviruses to infect specific cells, tissues, and species. This work will enhance our understanding of norovirus biology and pathogenesis and could reveal new targets for therapeutic intervention.

PI_NAMEs: ORCHARD, ROBERT C. (contact)

PROGRAM_OFFICER_NAME: LUNSFORD, DWAYNE

PROJECT_TERMS: Animal Model;Biological Models;Biology;Calicivirus;Cell Shape;Cells;Cellular Tropism;Data;Diarrhea;diarrheal disease;enteric infection;Escape Mutant;Evolution;Family;fitness;Gastroenteritis;genetic evolution;Genetic Variation;Goals;Human;In Vitro;in vivo;Infection;insight;Integration Host Factors;Intestines;Journals;Knowledge;Life Cycle Stages;link protein;member;Molecular;mouse model;Mus;new therapeutic target;Nonstructural Protein;Norovirus;Outcome;overexpression;pathogen;Pathogenesis;Peptide Hydrolases;permissiveness;Physiological;pressure;protein function;Proteins;receptor;Resistance;RNA Viruses;Role;Route;Shapes;System;Testing;Therapeutic;Therapeutic Intervention;Tissues;TRIM Family;TRIM Gene;Tropism;ubiquitin-protein ligase;Ubiquitination;vaccine access;Viral;viral fitness;Viral Pathogenesis;Viral Physiology;Viral Proteins;virology;Virus;Virus Diseases;Virus Replication;virus tropism;Work

PROJECT_TITLE: The Role of Trim Proteins in Regulating Norovirus Replication and Tropism


ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Prevention;Social Determinants of Health

PHR: Public Health Impact Preventing high school dropout, juvenile justice involvement, and early parenthood for those youth most at risk within urban environments is challenging. Experimentally testing the impact of a long-term professional mentoring program in a randomized controlled trial on these three outcomes can inform us of the impacts of such programs. Should this approach demonstrate strong evidence related to these outcomes, mentoring programs such as Friends of the Children may play an important preventive role reducing health disparities among “high-risk” individuals and their communities.

PI_NAMEs: EDDY, JOHN MARK;SKINNER, MARTIE L. (contact)

PROGRAM_OFFICER_NAME: ESPOSITO, LAYLA E

PROJECT_TERMS: 12 year old;21 year old;Achievement;Adolescent;Adoption;Adult;Age;anti social;apprenticeship;Area;Behavior;Behavioral;Boston;Caregivers;Caring;Child;Cities;Collection;Communities;comparison control;court;Data;Data Collection;Development;deviant;dosage;Dose;elementary school;Elements;Eligibility Determination;Enrollment;ethnic diversity;ethnic minority;Family;first grade;follow-up;Foundations;Friends;Funding;Future;girls;graduate school;Grant;Growth;high risk population;high school;Individual;interest;Intervention;intervention cost;intervention participants;Intervention Studies;Investigation;junior high school;Justice;juvenile justice system;kindergarten;Length;Life Style;Location;Low income;Measures;Mediating;Mentors;Modeling;National Institute of Child Health and Human Development;neighborhood disadvantage;Neighborhoods;New York City;Oregon;Outcome;Outcome Study;Parents;Participant;Perception;Personal Satisfaction;Play;Pregnancy;prevent;Preventive;preventive intervention;primary outcome;Privatization;Problem behavior;Program Evaluation;programs;psychosocial;Public Health;Publishing;racial minority;Randomized;Randomized, Controlled Trials;Records;recruit;Reduce health disparities;Reporting;Research;research and development;Risk;Role;Sampling;School Drop-Outs;Schools;Services;Site;social capital;Social Network;socioeconomic disadvantage;Student Dropouts;success;Supervision;Surveys;Testing;Time;Training;trial design;United States National Institutes of Health;urban setting;willingness;Wood material;Work;young adult;Youth

PROJECT_TITLE: A randomized controlled trial of Friends of the Children, a long-term professional mentoring program for adolescents at risk: impacts at post-test and 2 year follow-up

STUDY_SECTION: CLHP

STUDY_SECTION_NAME: Community-Level Health Promotion Study Section[CLHP]