ORG_CITY: HINES

ORG_NAME: EDWARD HINES JR VA HOSPITAL

ORG_STATE: IL

PHR: Spinal cord injury (SCI) affects ~42,000 Veterans. The VA provides the single largest network of SCI care in the nation. The lifetime financial burden of SCI can exceed $3 million. A major cost of SCI is impaired mobility. Limited mobility contributes to decreased ability to work, increased care requirements, secondary injury, depression, bone mineral density loss, diabetes, and decreased cardiovascular health. Among ambulatory individuals with iSCI, residual balance deficits are common and are strongly correlated with both functional walking ability and participation in walking activities. The development of effective rehabilitation tools to improve dynamic balance would substantially improve quality of life for Veterans living with iSCI. Improving mobility through interventions that enhance dynamic balance would positively impact health, independence, and the ability to integrate into social, intellectual, and occupational environments.

PI_NAMEs: GORDON, KEITH EDWARD (contact)

PROJECT_TERMS: Acceleration;Address;Affect;arm;Balance training;base;biomechanical test;Bone Density;Calibration;cardiovascular health;Caring;Chronic;Classification;Clinic;Clinical;clinical care;clinical development;clinical outcome measures;community setting;Control Groups;cost;Data;design;Detection;Development;Diabetes Mellitus;disability;Educational Intervention;Enrollment;Environment;equilibration disorder;Equilibrium;Evidence based intervention;experimental group;Feedback;Financial Hardship;Gait;Health;Home;Impairment;improved;improved mobility;Individual;Injury;International;Intervention;Knowledge;Laboratories;Learning;Locomotor training;Measures;Mental Depression;Mobility decline;Modeling;Monitor;Motion;Motor;motor control;motor impairment;motor learning;Movement;Nervous System;Neuromechanics;novel strategies;Occupational;Outcome;Participant;Pelvis;Periodicals;Population;Quality of life;Randomized;Reaction;Rehabilitation therapy;Research;Residual state;response;Robot;sedentary;Sensory;social;Spinal cord injury;Testing;Time;tool;Training;Training Programs;treadmill;Update;Veterans;Viscosity;Walking;walking speed;Work

PROJECT_TITLE: Amplify Gait to Improve Locomotor Engagement in Spinal Cord Injury (AGILE SCI Trial)

STUDY_SECTION_NAME: Musculoskeletal Health & Function[RRD2]


ADMINISTERING_IC: MH

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Genetics;Mental Health;Neurosciences

ORG_CITY: SAN FRANCISCO

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PSYCHIATRY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE Remodeling of the brain extracellular matrix (ECM) is a medium for synapse plasticity. However, how ECM production contributes to mammalian learning and memory remains unknown. We observed that depletion of aggrecan, a predominant hippocampal extracellular proteoglycan, from dentate gyrus neurons resulted in a deficit in pattern separation, a key hippocampal memory function. This proposal will build off these preliminary data to dissect how learning-induced aggrecan production influences ensemble properties to stabilize hippocampal memories.

PI_NAMEs: GUAJARDO, RICARDO  (contact)

PROGRAM_OFFICER_NAME: DRISCOLL, JAMIE DANIELLE

PROJECT_TERMS: Adult;aggrecan;Animals;Behavioral;Brain;brain remodeling;Calcium;California;career;Chondroitin Sulfate Proteoglycan;clinical training;conditional knockout;conditioned fear;critical period;Data;Dendrites;dentate gyrus;Deposition;Digestion;Discrimination;Disease;Dorsal;educational atmosphere;Endoscopy;Environment;Episodic memory;experimental study;extracellular;Extracellular Matrix;Fright;Functional disorder;Genes;Genetic;Genetic Recombination;Goals;granule cell;Hippocampus;Hour;Hyaluronic Acid;Image;Immunofluorescence Immunologic;Impairment;In Situ Hybridization;insight;knockout animal;Label;Learning;link protein;Logic;Measures;Mediating;medical schools;Memory;memory acquisition;memory consolidation;Memory impairment;memory process;Mentors;Mentorship;Messenger RNA;Microscopy;Molecular;Mus;Nerve Degeneration;Nervous System;Neurons;neuropsychiatric disorder;Neurosciences Research;novel;Output;Parahippocampal Gyrus;Pathogenesis;Pattern;Physicians;Physiological;Population;Process;Production;Property;Proteoglycan;Qualifying;Research;residence;Retrieval;Role;San Francisco;Scientist;Source;Structure;Synapses;Synaptic plasticity;System;Technical Expertise;Testing;Therapeutic;Time;Training;Universities;Vertebral column

PROJECT_TITLE: Elucidating the Role of Brain Extracellular Matrix in Hippocampal Learning and Memory


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Mental Health;Mental Illness;Neurosciences;Pediatric;Social Determinants of Health

ORG_CITY: CHAPEL HILL

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE Although theories of adversity suggest that childhood threat exposure sensitizes neural and emotional response systems in ways that both increase risk for psychopathology and promote adaptation, most research has focused on negative health outcomes (i.e., psychopathology) among adversity-exposed youth. This study will examine how threat exposure predicts neural sensitivity to negative and positive social-emotional information and how this sensitivity interacts with peer experiences to shape changes in negative (i.e., depression) and positive (i.e., social-emotional wellbeing) health outcomes. Results will improve knowledge of the ways adolescents leverage adversity-linked sensitivity to social-emotional cues in order to benefit from environmental support and will identify strengths to be targeted to support better mental health among adversity-exposed youth.

PI_NAMEs: DAVIS, MEGAN  (contact)

PROGRAM_OFFICER_NAME: CORNELL, ASHLEY ROSE

PROJECT_TERMS: Address;Adolescence;Adolescent;Adolescent Development;adolescent mental health;adverse outcome;Affect;Affective;aged;Behavior assessment;Behavioral;Brain;Calibration;career development;Caregivers;child depression;Childhood;community violence;Cues;Data;Data Collection;depressive symptoms;Development;early childhood;early life adversity;Emotional;Emotions;Enrollment;Environment;Evaluation;experience;Exposure to;Feedback;Fostering;Functional Magnetic Resonance Imaging;Goals;Health;improved;Interview;Knowledge;life span;Link;longitudinal analysis;Longitudinal Studies;Measures;Mental Depression;Mental disorders;Mental Health;Mentorship;Methods;Modeling;National Institute of Mental Health;neglect;neural;Neural Network Simulation;neuroimaging;Neurosciences;novel;Outcome;Parents;Participant;Patient Self-Report;peer;peer networks;Personal Satisfaction;Physiological;prevent;protective factors;psychologic;psychological distress;Psychopathology;psychosocial outcome;Questionnaires;Reporting;Research;Research Support;Resources;response;Risk;Risk Factors;Role;Sampling;Science;Shapes;social;social engagement;Social Environment;Social Processes;Statistical Data Interpretation;Strategic Planning;Stress;supportive environment;System;Taxes;theories;Time;Training;Visit;Well in self;Work;Youth

PROJECT_TITLE: Neural sensitivity to social feedback following adversity: Implications for adolescent mental health

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F16-L(20)L]


ADMINISTERING_IC: MD

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cardiovascular;Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Pediatric;Pregnancy;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: DURHAM

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: DUKE UNIVERSITY

PHR: PROJECT NARRATIVE Black women in the United States develop high-risk pregnancy conditions such gestational diabetes and hypertensive disorders of pregnancy at much higher rates than White or Latina women, which increases their risk for poor outcomes during pregnancy and after birth. This study will help us to understand how different experiences with gender and race-based oppression, gendered racism, and resilience are related to high-risk pregnancies among Black women. The study findings will provide important information that can be used to develop new ways to improve the health of Black women.

PI_NAMEs: JAYNES, SHEWIT  (contact)

PROGRAM_OFFICER_NAME: LINARES, DEBORAH ELIZABETH

PROJECT_TERMS: Address;Adolescence;Adolescent;Adult;adverse pregnancy outcome;Affect;Age;allostatic load;Automobile Driving;Binding;Birth;black men;black subgroup;black women;Body mass index;cardiometabolism;Cardiovascular Diseases;case control;cellular resilience;Chronic;classism;combat;Data;Diabetes Mellitus;Discrimination;disease disparity;Disparity;Education;Educational Status;Environment;experience;Exposure to;Family;family support;Fostering;Future;Gender;Gestational Diabetes;Goals;Growth;Health;health disparity;health equity;health inequalities;High Prevalence;High-Risk Pregnancy;Hybrids;Hypertension;improved;Income;Individual;Inequality;Inequity;innovation;insight;intersectionality;Intervention;Joints;Latina;Link;Literature;Logistic Regressions;Longitudinal Studies;Maternal Health;maternal morbidity;Maternal Mortality;Mediator;Mental Health;Methodology;Mission;National Institute of Nursing Research;National Longitudinal Survey of Adolescent to Adult Health;Nature;Nurses;Outcome;perceived discrimination;physical conditioning;Play;population health;Pregnancy;pregnancy disorder;Pregnancy Histories;Pregnancy Outcome;prevent;psychologic;Race;racial discrimination;racism;Recording of previous events;Recovery;Reporting;Research;resilience;Resistance;Risk;Risk Factors;Role;Scientist;Sexism;social health determinants;Societies;Source;Spirituality;Stress;stressor;Structural Racism;Subgroup;United States;White Women;Woman

PROJECT_TITLE: Gendered Racism Profiles, Resilience, and High-Risk Pregnancies Among Black Women

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F18-E(20)L]


ADMINISTERING_IC: HL

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Coronaviruses;Coronaviruses Diagnostics and Prognostics;Emerging Infectious Diseases;Hematology;Infectious Diseases;Lung

ORG_CITY: MADISON

ORG_DEPT: PHYSICS

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE Pulmonary embolism (PE) is a venous thromboembolic event associated with high morbidity and mortality, with about 20% incidence of death. Recently, the COVID-19 pandemic has contributed to a marked increase in patients presenting with acute pulmonary thromboembolic disease. It is increasingly being recognized that pulmonary perfusion abnormalities are important predictors of poor prognosis in PE patients. This project will develop a new spectral CT imaging method to provide simultaneous pulmonary CT angiography and parenchymal perfusion assessment without the requirement of high-end dual energy CT hardware or any non- CT imaging modalities.

PI_NAMEs: CHEN, GUANG-HONG  (contact);LI, KE

PROGRAM_OFFICER_NAME: HALLER, JOHN WAYNE

PROJECT_TERMS: Accident and Emergency department;Acute;Age;Angiography;Animals;Blood Volume;Cessation of life;Chronic;chronic thromboembolic pulmonary hypertension;Clinical;clinical risk;Coagulation Process;commercialization;contrast enhanced computed tomography;COVID-19 diagnosis;COVID-19 pandemic;COVID-19 pneumonia;Data;deep learning;Defect;Diagnosis;diagnostic accuracy;Disease;Economic Burden;Endothelium;Evaluation;Event;Fibrin fragment D;Functional Imaging;Glass;global health;Health;human subject;Image;imaging modality;improved;Incidence;innovation;Iodine;Laboratories;lifetime risk;Lung;lung imaging;Manufacturer;Maps;Methods;Modality;Modeling;Morbidity - disease rate;Morphologic artifacts;Morphology;mortality;Motion;network models;Patients;Perfusion;perfusion imaging;Physics;predictive tools;Prognosis;Pulmonary Embolism;Pulmonary Infarction;Pulmonary vessels;Radiation Dose Unit;Radionuclide Imaging;Recurrence;Research;SARS-CoV-2 infection;Serology test;single photon emission computed tomography;Structure of parenchyma of lung;Study Subject;Symptoms;technological innovation;technology development;Thrombophilia;Thrombosis;United States;Vasculitis;Venous;venous thromboembolism;ventilation;X-Ray Computed Tomography

PROJECT_TITLE: Functional Lung Imaging Using a Single kV CT Acquisition

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Emergency Care;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Pediatric;Rural Health;Social Determinants of Health

ORG_CITY: BOSTON

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

ORG_STATE: MA

PHR: Project Narrative Disparities in child mortality and morbidity have been documented for decades, and recent evidence suggests the urban-rural gap is increasing. 20% of America's 74.1M children live in rural areas. This proposal leverages our experience, relationships, and robust processes to investigate and address preventable out of hospital rural child mortality

PI_NAMEs: GUISE, JEANNE-MARIE  (contact)

PROGRAM_OFFICER_NAME: PEMBERTON, VICTORIA

PROJECT_TERMS: Academy;acceptability and feasibility;Address;American;Attenuated;Big Data;Birth;Cardiopulmonary Arrest;care delivery;care systems;Caring;Cessation of life;Child;Child Health;Child Mortality;Clinical;Cognitive;comparative;Critical Illness;Data;Decision Making;Disparity;disparity reduction;Effectiveness;Emergency Care;Emergency medical service;Emergency Situation;Epidemiology;Event;experience;Frequencies;Health;health care delivery;health management;Healthcare Systems;improved;improved outcome;Infant;Infant Mortality;Injury;Intervention;Investigation;Knowledge;Life;Link;Logic;Measurable;Medicine;Morbidity - disease rate;mortality;mortality disparity;Nature;novel;novel strategies;Outcome;pediatric emergency;Pediatric Hospitals;pediatric patients;Performance;Play;population based;preventable death;Process;Quality of Care;Reporting;Research;Resources;Respiratory distress;response;Resuscitation;Risk;Role;Rural;rural America;rural area;Rural Community;rural disparities;rural health disparities;Rural Hospitals;rural setting;Safety;Seizures;service providers;Socioeconomic Status;Source;System;Testing;Time;Trauma;urban area;urban children;urban setting;Vital Statistics;Work

PROJECT_TITLE: Reducing Disparities for Children in Rural Emergency Resuscitation (RESCU-ER)

STUDY_SECTION: HSQE

STUDY_SECTION_NAME: Health Services: Quality and Effectiveness Study Section[HSQE]


ORG_CITY: ANN ARBOR

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative Aortic aneurysm is a major medical concern due to the increasing prevalence and high mortality rate. The pathophysiology of this disease is largely unknown which limits the development of drug targets. The proposed project is relevant for public health because it will establish a novel therapeutic target aimed to manage this asymptomatic disease with a high mortality rate.

PI_NAMEs: CHANG, LIN  (contact)

PROGRAM_OFFICER_NAME: STABLEY, JOHN N

PROJECT_TERMS: abdominal aorta;Abdominal Aortic Aneurysm;Address;Adult;Affect;Aneurysm;Animal Model;Aorta;Aortic Aneurysm;Apolipoprotein E;Apoptosis;Binding;Biological Availability;Blood Vessels;Brown Fat;Cardiac Myocytes;Cardiovascular Diseases;Cell Physiology;Cell Proliferation;Cells;Clinical;Conjugated Linoleic Acids;Crossbreeding;cytokine;Data;Death Rate;Dependence;Development;Developmental Process;Disease;Disintegrins;Dissection;drug development;Drug Targeting;Elastin;Eligibility Determination;Embryo;Fatty Acids;Foundations;Functional disorder;Gene Expression;Generations;Genes;Genetic Transcription;genome wide association study;Germ Lines;Heart;Hematopoiesis;Hematopoietic;Homeostasis;Human;Impairment;in vivo;Inflammation;Knock-in Mouse;Knock-out;Knockout Mice;Lesion;Life;loss of function;LoxP-flanked allele;Lysine;Mediating;Medical;Messenger RNA;Metalloproteases;migration;Modeling;Morbidity - disease rate;mortality;Mus;Neonatal;new therapeutic target;next generation;nitrated conjugated linoleic acid;nitration;Nitrites;Nitrogen Dioxide;novel;Oleic Acids;Omega-3 Fatty Acids;Operative Surgical Procedures;Oral;Oral Administration;oral supplementation;Oxidants;oxidation;Pathologic;Patients;Pharmaceutical Preparations;pharmacologic;Play;Positioning Attribute;Prevalence;prevent;Prevention;Procedures;Production;protective effect;Proteins;Public Health;Regulation;repaired;Research;Resistance;Role;Rupture;Ruptured Aortic Aneurysms;Signal Pathway;Signal Transduction;Smooth Muscle Myocytes;Solid;Stimulus;Stomach;Surgical complication;Tamoxifen;Therapeutic;transcriptome sequencing;Transforming Growth Factor beta;Transforming Growth Factor beta Receptors;Transgenic Organisms;Vascular Smooth Muscle;vascular smooth muscle cell proliferation;Work

PROJECT_TITLE: Smooth muscle cell PRDM16 and aortic aneurysm

STUDY_SECTION: AICS

STUDY_SECTION_NAME: Atherosclerosis and Inflammation of the Cardiovascular System Study Section[AICS]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: CLEVELAND

ORG_NAME: LOUIS STOKES CLEVELAND VA MEDICAL CENTER

ORG_STATE: OH

PHR: Incomplete spinal cord injuries result in partial loss of strength in the muscles below the level of injury. This leads to reduced physical activity and subsequent loss of muscle mass, cardiovascular disease, peripheral vascular dysfunction and obesity. Optimizing exercise training protocols that will safely improve muscle strength, fatigue resistance and vascular function is imperative in this population, not only to increase exercise tolerance and physical activity but also the ability to perform activities of daily living and quality of life. This is especially important for veterans as they are overrepresented in the SCI population and their care places a major financial burden on the VA healthcare system.

PI_NAMEs: MCDANIEL, JOHN  (contact)

PROJECT_TERMS: Activities of Daily Living;Area;arterial stiffness;Benefits and Risks;Blood;Blood flow;Blood Vessels;bone loss;C-reactive protein;Cardiovascular Diseases;Cardiovascular Physiology;Caring;Chronic;Circulation;Clinical;cytokine;Development;Educational Intervention;Endothelium;Exercise;exercise capacity;exercise intensity;exercise intolerance;exercise prescription;exercise program;Exercise Tolerance;exercise training;experience;extracellular;Fatigue;Financial Hardship;functional electrical stimulation;functional restoration;Future;General Population;Goals;Health;Healthcare Systems;hypoxia inducible factor 1;immune activation;Immunologic Markers;Impairment;improved;Incidence;Individual;Inflammatory;Injury;Interferons;Interleukin-1 beta;Interleukin-6;Intervention;Investigation;Isotonic Exercise;Knee;Lesion;light intensity;Limb structure;long-term rehabilitation;Measurement;Mediating;Mental Depression;Metabolic Diseases;mode of exercise;motor impairment;Muscle;muscle form;Muscle function;muscle strength;Muscular Atrophy;nerve supply;neutrophil;Nitric Oxide;novel;Obesity;Peripheral;Persons;Physical activity;Physiologic pulse;Platelet aggregation;Population;Prevalence;programs;Protocols documentation;Publications;Quality of life;reactive hyperemia;recruit;Rehabilitation therapy;Research;Resistance;resistance exercise;Risk;Safety;scaffold;Series;Skeletal Muscle;Spinal cord injury;Testing;Thrombosis;Training;United States;Vascular Diseases;Vascular Endothelium;Veterans;Walking;Weight Gain

PROJECT_TITLE: Blood flow restriction exercise to improve skeletal muscle and peripheral vascular function in person with spinal cord injuries

STUDY_SECTION: RRDD

STUDY_SECTION_NAME: Musculoskeletal Health & Function[RRDD]


ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: SAINT PAUL

ORG_NAME: MINNESOTA STATE DEPT OF AGRICULTURE

ORG_STATE: MN

PHR: Project Narrative The Minnesota Department of Agriculture seeks to advance efforts for a national integrated food safety system (IFSS) by continuing to develop Minnesota’s Produce Safety Program and its work in inspections, outreach, engagement and education to enhance produce safety and achieve high rates of compliance with the FDA’s Produce Safety Rule. The goal of the project will be to further the MDA Produce Safety Program’s mission to engage farmers by providing access to innovative learning opportunities and by conducting risk-based inspections resulting in safe and healthy Minnesota produce.

PI_NAMEs: BAYSAL, NICOLE  (contact);LUEDEMAN, JEFF

PROGRAM_OFFICER_NAME: SCHMIDT, ANDREA

PROJECT_TITLE: Path C Enhancing Produce Safety in Minnesota through a National Produce Safety Program


ADMINISTERING_IC: AG

ED_INST_TYPE: UNIVERSITY-WIDE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Dietary Supplements;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Menopause;Microbiome;Nutrition;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Urologic Diseases;Women's Health Research

ORG_CITY: BOZEMAN

ORG_NAME: MONTANA STATE UNIVERSITY - BOZEMAN

ORG_STATE: MT

PHR: Project Narrative The genitourinary syndrome of menopause (GSM) is an age-related, chronic, urogenital and sexual condition that disproportionately affects racial and ethnic minorities and contributes >$3 billion annually to US healthcare costs. My research indicates aging is associated with an increase in vaginal metabolites linked to oxidative stress and cellular damage and a concomitant decline in antioxidant and anti-inflammatory metabolites. I propose an integrative multi-omic (metabolomic, immunology, and microbiome) and machine learning approach to better understand these complex interactions, their role in urogenital age-related pathologies, and if race/ethnicity specific differences contribute to disparate rates of age-related pathologies in racial/ethnic minorities.

PI_NAMEs: BORGOGNA, JOANNA-LYNN C (contact)

PROGRAM_OFFICER_NAME: CARTER, CHRISTY

PROJECT_TERMS: Advocate;Affect;Age;age related;Age related pathologies;age-related disease;aged;Aging;Alzheimer's Disease;Anti-Inflammatory Agents;antioxidant therapy;Antioxidants;Attenuated;Award;Biological Assay;Biological Markers;Cardiovascular Diseases;career;cell injury;Cerebrospinal Fluid;Chronic;Chronology;Clinical;Clinical Data;cohort;Communities;Complex;cost;cytokine;Data;Development;Diagnosis;Diagnostic;Diet;Disparate;Doctor of Philosophy;Dryness;early experience;Epidemiology;Epithelial Cells;estrogen disruption;Estrogen Therapy;Estrogens;ethnic minority;Ethnic Minority Women;Ethnic Origin;Evaluation;Exposure to;First Generation College Students;Genitourinary system;Glean;Glutathione;Glycine;Goals;Gynecologic;Health Care Costs;high risk;Human;Immunology;improved;In Vitro;infection rate;Inflammation;Inflammatory Response;innovation;insight;Intervention;K-Series Research Career Programs;Knowledge;Latina;Link;lipid metabolism;Lipid Peroxidation;Lipids;Longitudinal cohort;Lubricants;Lubrication;Machine Learning;machine learning method;marginalization;Mediating;Mediation;Medical;Menopausal Status;Menopausal Syndrome;Mentors;Metabolism;Metabolite Interaction;metabolome;metabolomics;Methods;Microbe;microbial host;Microbiology;microbiome;microbiota;Modality;Modernization;Mucous Membrane;multiple omics;Not Hispanic or Latino;novel;novel therapeutics;older adult;older women;Osmosis;Osteoporosis;Outcome;Oxidative Stress;Oxidative Stress Induction;Pain;Participant;Pathology;personalized intervention;Phase;Plasma;Population;post-doctoral training;Postmenopause;Predisposition;Preparation;Prevention;Process;Pruritus;Publications;Quality of life;Race;racial minority;racial minority women;Recurrence;reduce symptoms;reproductive;Reproductive Biology;Research;Research Personnel;Risk;Role;Sampling;Serum;Sex Functioning;Sexual Health;Sexually Transmitted Diseases;side effect;Signs and Symptoms;skills;social stigma;Sphingolipids;statistics;Stress;Structural Models;Symptoms;Therapeutic Agents;Vagina;vaginal lactobacilli;vaginal microbiota;Validation;validation studies;Vitamins;White Women;Woman;Work;Youth

PROJECT_TITLE: A multi-omic and integrative longitudinal evaluation of the role of lipid, antioxidant, and osmoprotectant metabolites in the genitourinary syndrome of menopause by race and ethnicity.


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Chronic Pain;Natural Products;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy

ORG_CITY: SALT LAKE CITY

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Project Narrative The somatosensory system is crucial to many diseases, especially chronic, debilitating pain. Here, we will discover and develop natural products that selectively target individual somatosensory drug subtypes, and that therefore may ultimately find use in treating neuropathic pain and cold allodynia.

PI_NAMEs: SCHMIDT, ERIC W (contact)

PROGRAM_OFFICER_NAME: MOHAPATRA, DURGA PRASANNA

PROJECT_TERMS: addiction;Address;Affect;Afferent Neurons;allodynia;Animal Disease Models;Animal Model;animal model selection;Animals;Behavioral;Biological Assay;Biological Process;Biology;body position;Cardiac;cell type;Cells;cellular imaging;Chemicals;Chemistry;Chronic;chronic pain;chronic pain management;chronic painful condition;Classification;Constipation;Data;debilitating pain;Dedications;Development;Disease;drug action;Drug Targeting;Elan brand of omega-conopeptide MVIIA;Electrophysiology (science);Esthesia;FDA approved;Health;Human;in vivo;Individual;innovation;Ion Channel;Lead;Ligands;Maps;Mechanics;Mediating;Medical;Mental Depression;Methods;microbiome;Molecular Target;Movement;Natural Compound;Natural Products;Nervous System;Nervous System Disorder;Neurons;Neuropathy;Neuropharmacology;novel;novel therapeutics;opioid epidemic;Pain;Pain management;pain model;pain sensation;painful neuropathy;Peripheral;Persons;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacologic;Pharmacology;Physiological;programs;Pruritus;Reaction;receptor;recruit;response;Role;Sensory;sensory system;side effect;Signal Transduction;somatosensory;Specificity;Spinal Ganglia;synergism;System;Testing;Therapeutic;Therapeutic Agents;therapeutic evaluation;therapeutic target;Time;tool;Touch sensation;Treatment Efficacy;United States;Ventilatory Depression;Visualization;Work;ziconotide

PROJECT_TITLE: Modulating single cell types in the sensory nervous system

STUDY_SECTION: DDNS

STUDY_SECTION_NAME: Drug Discovery for the Nervous System Study Section[DDNS]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Aging;Autoimmune Disease;Behavioral and Social Science;Brain Disorders;Clinical Research;Genetics;Lupus;Neurosciences

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: Northwestern University  PROJECT NARRATIVE As diagnosis of neuropsychiatric systemic lupus erythematosus (NP-SLE) is a challenge due to the lack of definitive causal mechanisms underlying disease, our proposed use of multiple mouse models of NP-SLE, including our novel Caspase-8 Removed CD11c-specific Overactive MyD88 (CReCOM) model, as well as patient blood and cerebrospinal fluid samples, has the potential to deliver innovative and transcending mechanisms for brain-resident macrophage-specific control of NP-SLE pathogenesis not feasibly achieved via in vitro analyses. Since diagnostic strategies for NP-SLE are limited, patients with NP-SLE often fail to achieve remission using current therapies and side effects from treatment are substantial, the ultimate objective is to utilize these research discoveries to help in the development of targeted laboratory diagnostic tests as well as safer, more effective therapies for NP-SLE.

PI_NAMEs: CUDA, CARLA M (contact)

PROGRAM_OFFICER_NAME: RICE, JEFFREY S

PROJECT_TERMS: aged;Aging;Alzheimer's Disease;Amyotrophic Lateral Sclerosis;antagonist;Autopsy;Behavior;Behavioral;behavioral outcome;Biometry;Biopsy;Blood;Bone Marrow;Brain;brain cell;CASP8 gene;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Cerebrospinal Fluid;chronic autoimmune disease;Clinical;comorbidity;Data;Defect;Development;Diagnosis;Diagnostic;diagnostic strategy;Diagnostic tests;Discipline;Disease;Disease associated microglia;Disease remission;effective therapy;Environmental Risk Factor;Ethics;Exhibits;experience;Gene Expression Profile;Gene Expression Profiling;Genes;Genetic;Genetic Transcription;Head;health related quality of life;Heterogeneity;Hippocampus;Human;IFNAR1 gene;immune cell infiltrate;Immunology;Impaired cognition;improved;In Vitro;Individual;innovation;Interferon Type I;Interferons;Investigation;ITGAX gene;Laboratories;Link;Literature;Macrophage;Macrophage Colony-Stimulating Factor Receptor;Mediator;Microglia;Modeling;Molecular;monocyte;mouse model;Mus;neuroimmunology;Neuropsychiatric Systemic Lupus Erythematosus;novel;novel therapeutics;Outcome;Pathogenesis;Pathogenicity;Pathology;Pathway interactions;Patient-Focused Outcomes;Patients;peripheral blood;Phagocytes;Phagocytosis;Play;Population;Predisposition;prevent;programs;PTPRC gene;Publications;Publishing;Quality of life;receptor;Receptor Signaling;Research;Research Personnel;Role;Sampling;Severities;Signal Transduction;Signaling Protein;single-cell RNA sequencing;Sorting;Sphingosine-1-Phosphate Receptor;synaptic pruning;systemic autoimmunity;Systemic disease;Systemic Lupus Erythematosus;Target Populations;targeted treatment;Testing;Time;Tissues;Transcend;transcriptome sequencing;Treatment Side Effects;TREM2 gene;Universities

PROJECT_TITLE: The Relationship Between Brain Macrophages and Cognitive Dysfunction in Systemic Lupus Erythematosus

STUDY_SECTION: HAI

STUDY_SECTION_NAME: Hypersensitivity, Autoimmune, and Immune-mediated Diseases Study Section[HAI]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Pediatric;Prevention;Substance Misuse;Underage Drinking

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PUBLIC HEALTH RELEVANCE: Alcohol use is associated with significant harm in college populations, including all three leading causes of death (accidents, suicide, homicide). The current application continues a program of research to reduce alcohol use and consequences among college students, and seeks to enhance efficacy, effect sizes, and duration of electronic screening and brief interventions for this population through evaluating optimal program delivery (simultaneous or sequential) for personalized feedback interventions (PFIs), text-message boosters targeting high-risk drinking events, and impact of intervention and assessment timing on outcomes. Answers to these questions will have immediate implications for dissemination and implementation on campuses nationwide to address alcohol-related harm.

PI_NAMEs: LARIMER, MARY E. (contact)

PROGRAM_OFFICER_NAME: KERRIDGE, BRADLEY TOWNSEND

PROJECT_TERMS: Accidents;Address;Adult;alcohol consequences;Alcohol consumption;alcohol misuse;alcohol research;alcohol risk;Alcohols;Apple;Attention;Attenuated;Calendar;Cause of Death;Cellular Phone;clinical practice;cohort;college;college drinking;Comprehension;Confusion;design;Development;Dissemination and Implementation;distraction;drinking;efficacious intervention;efficacy evaluation;Electronics;Environment;Epidemiology;Evaluation;Event;falls;Feedback;follow up assessment;heavy drinking college student;heavy drinking students;high risk;high risk drinking;Homicide;implementation intervention;Individual;innovation;Internet;Intervention;intervention delivery;intervention effect;Light;Literature;Manufactured football;Mediator;National Institute on Alcohol Abuse and Alcoholism;normative feedback;novel strategies;Outcome;Participant;personalized normative feedback;Population;Population Intervention;Prevention;programs;Progress Reports;public health priorities;public health relevance;Randomized;recruit;reduced alcohol use;Research;Research Design;screening and brief intervention;Seasons;skills training;social norm;social skills;Suicide;tailored text messaging;Text Messaging;text messaging intervention;Time;Treatment Efficacy;university student;young adult

PROJECT_TITLE: Social Norms & Skills Training: Motivating Campus Change

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Genetics;Infectious Diseases;Prevention;Tobacco;Tobacco Smoke and Health

ORG_CITY: LOUISVILLE

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF LOUISVILLE

ORG_STATE: KY

PHR: PROJECT NARRATIVE Tobacco smoking is the leading environmental cause of periodontitis (a destructive gum disease). Many periodontal pathogens are highly resistant to the plethora of toxic insults contained in cigarette smoke, including the representative bacterium, Porphyromonas gingivalis. We will identify and characterize those P. gingivalis genes that facilitate this Gram-negative anaerobe not only to survive, but to thrive, in tobacco-rich environments.

PI_NAMEs: SCOTT, DAVID A (contact)

PROGRAM_OFFICER_NAME: MCNEALY, TAMARA L

PROJECT_TERMS: Abscess;Adult;Alveolar Bone Loss;Anaerobic Bacteria;Award;Bacteria;Basic Science;biological adaptation to stress;Biological Assay;Biological Process;Blood Vessels;Cells;Chronic;Cigarette;cigarette smoke;cigarette smoke-induced;Clinical;Communicable Diseases;Complex;Consumption;Data;Databases;Developed Countries;Diabetes Mellitus;Disease;Dose;Economic Burden;Environment;Epidemiology;Epithelial Cells;Epithelium;Essential Genes;Exhibits;Exposure to;Financial cost;fitness;Funding Mechanisms;Future;Gene Deletion;Genes;Genome;Gingiva;Growth;Health;Homologous Gene;Immune;immune resistance;Immune response;In Vitro;in vivo;Infection;infection rate;Inflammation;insight;Invaded;Libraries;Lung Diseases;Modeling;mouse model;Mouth Diseases;Mus;mutant;National Institute of General Medical Sciences;New Zealand;Nicotine;non-smoker;novel;novel vaccines;Oral;Oral cavity;oral cavity epithelium;Osteitis;pathogen;Patients;Peptide Hydrolases;Periodontal Diseases;Periodontitis;periodontopathogen;Persons;Physiology;Population;Porphyromonas gingivalis;Predisposition;Premature Birth;Prevention;Refractory;Research;Resistance;Resources;Scandinavia;Smoke;Smoker;Smoking;Standardization;Stress;Subcutaneous abscess;success;System;Testing;therapeutic target;Tissues;Tobacco;tobacco regulation;Tobacco smoke;tobacco smoke exposure;Tobacco smoking behavior;Tooth structure;Toxin;trait;transcriptome;transcriptome sequencing;translational potential;transposon sequencing;Treatment Protocols;Variant;Vascular Diseases;Virulence;Work

PROJECT_TITLE: P. gingivalis genes essential for tobacco smoke survival


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Biotechnology;Diabetes;Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: PHILADELPHIA

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Narrative Human genetic studies have identified hundreds of type 2 diabetes-associated genetic loci, but the mechanisms through which most of these loci affect disease susceptibility remain poorly understood. Our multidisciplinary team will perform comprehensive functional assessments of candidate T2D-effector transcripts in human cell and mouse models of diabetes with the goal of identifying new therapeutic avenues.

PI_NAMEs: GRANT, STRUAN F A;KAESTNER, KLAUS H;RADER, DANIEL JAMES;SEALE, PATRICK  (contact);VOIGHT, BENJAMIN FRANKLIN;YANG, WENLI

PROGRAM_OFFICER_NAME: ZAGHLOUL, NORANN

PROJECT_TERMS: Ablation;Adipocytes;Affect;Animals;Area;ATAC-seq;biobank;bioinformatics pipeline;Biological;Biological Process;Biology;Biometry;Blindness;Candidate Disease Gene;candidate identification;Cardiovascular Diseases;causal variant;Cause of Death;Cell model;cell type;Cells;chromosome conformation capture;Chronic;clinical translation;Collaborations;Collection;Communities;Complex;computational pipelines;conditional mutant;Data;Data Set;Diabetes Mellitus;diabetes pathogenesis;Diabetic mouse;Disease;disease model;Disease susceptibility;Engineering;follow-up;Functional disorder;functional genomics;Funding;gain of function;gene interaction;gene network;gene regulatory network;Genes;Genetic;Genetic Engineering;Genetic Predisposition to Disease;Genetic study;genome wide association study;genome-wide;Genomic approach;genomic data;genomic locus;Genomics;Goals;Health;Hepatocyte;Heterogeneity;Human;Human Genetics;human induced pluripotent stem cells;human stem cell-derived;human tissue;Hyperglycemia;in vivo;in vivo evaluation;Individual;induced pluripotent stem cell;Insulin Resistance;Investigation;Kidney Failure;Knowledge;Liver;loss of function;Malignant Neoplasms;Maps;Metabolic;Methods;Modeling;Molecular;molecular phenotype;mouse model;multidisciplinary;multiple data sources;Mus;Muscle Fibers;mutant;mutant mouse model;Mutant Strains Mice;Neuropathy;new therapeutic target;Non-Insulin-Dependent Diabetes Mellitus;novel therapeutics;Obesity;Pancreas;Pathway Analysis;Pathway interactions;Patients;Pediatric Hospitals;Pennsylvania;Phenotype;Philadelphia;Physiological;Population Genetics;Positioning Attribute;Predisposition;Prevalence;Process;programs;Regulation;Research;Resources;Role;Skeletal Muscle;Source;stem cell model;stem cells;Structure of beta Cell of islet;System;Testing;Therapeutic;therapeutic target;Tissues;trait;Transcript;transcriptome sequencing;United States National Institutes of Health;Universities;Untranslated RNA;Variant;Veterans

PROJECT_TITLE: Functional Interrogation of T2D-associated genes in human stem cell-derived models and mice


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Breast Cancer;Cancer;Immunotherapy;Women's Health Research

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PROJECT NARRATIVE Triple-negative breast cancer (TNBC) is refractory to molecularly targeted therapies, but is addicted to one of the amino acids, glutamine, for growth and survival. This vulnerability of TNBC will be investigated in the current proposal as a target for therapeutic intervention, using a novel glutamine transporter inhibitor.

PI_NAMEs: BOOTHBY, MARK R;CHEN, JIN  (contact)

PROGRAM_OFFICER_NAME: TANDON, PUSHPA

PROJECT_TERMS: adaptive immunity;Adjuvant;Affect;Allografting;Amino Acids;anti-tumor immune response;Biological Assay;Biological Models;Breast Cancer Cell;Breast Cancer Model;cancer cell;cancer imaging;CD8-Positive T-Lymphocytes;cell growth;Cell Physiology;Cells;Clinical Trials;Coculture Techniques;Collaborations;Consumption;cytotoxic CD8 T cells;Data;Exhibits;glucose metabolism;Glutaminase;Glutamine;Glycolysis;Growth;Image;Immune;immunodeficiency;Immunotherapy;Implant;improved;In Situ;In Vitro;in vivo;indexing;Infiltration;inhibitor;Intercellular Fluid;interest;interstitial;Knock-out;Knowledge;Lymphocyte;Lymphocyte Activation;Lymphocyte Count;Lymphocyte Function;Lymphocytic Infiltrate;macromolecule;Malignant Breast Neoplasm;Malignant Epithelial Cell;Malignant Neoplasms;Maps;mass spectrometric imaging;Mass Spectrum Analysis;Measures;Metabolic;Metabolism;Modeling;molecular subtypes;molecular targeted therapies;Mus;Neoplasm Metastasis;neoplastic cell;novel;novel therapeutic intervention;Nutrient;Oncogenic;Patient-derived xenograft models of breast cancer;Patients;pharmacologic;Phenotype;Play;Positioning Attribute;Positron-Emission Tomography;Prognosis;programs;Proliferating;recruit;Refractory;Role;spatial relationship;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;success;System;T-Cell Activation;T-Lymphocyte;targeted treatment;Testing;Therapeutic;Therapeutic Intervention;Toxic effect;Transgenic Model;treatment response;treatment strategy;triple-negative invasive breast carcinoma;tumor;Tumor Escape;tumor growth;Tumor Immunity;tumor microenvironment;Tumor-Infiltrating Lymphocytes;Up-Regulation;uptake;Woman

PROJECT_TITLE: Effect of tumor cell glutamine metabolism on anti-tumor immunity in TNBC

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-M(08)F]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Prostate Cancer;Racial and Ethnic Minority Health Research;Social Determinants of Health;Urologic Diseases

ORG_CITY: TAMPA

ORG_NAME: H. LEE MOFFITT CANCER CTR & RES INST

ORG_STATE: FL

PHR: PROJECT NARRATIVE! This will be among the ﬁrst and most comprehensive studies we are aware of to compare symptom burden between African American and White prostate cancer survivors, and it will be the ﬁrst to identify modiﬁable and non-modiﬁable risk factors for symptom burden in this population. Identifying risk factors for these outcomes will 1) allow us to develop interventions that target risk factors using evidence-based approaches and 2) lead to development of early support interventions for survivors at greatest risk.

PI_NAMEs: GONZALEZ, BRIAN D (contact)

PROGRAM_OFFICER_NAME: GALLICCHIO, LISA M

PROJECT_TERMS: African American;African American population;Age;Awareness;Behavioral;biobank;cancer diagnosis;cancer health disparity;Cancer Survivor;Clinical;Clinical Data;cohort;Consent;Data;Decision Making;Demographic Factors;Development;Diagnosis;Disparity;disparity reduction;DNA Library;Early Intervention;Education;evidence base;experience;Florida;Frequencies;Functional disorder;Future;Genetic;Goals;Health behavior;health disparity;Healthcare Systems;Healthy People 2020;high risk men;high risk population;Hormonal;improved;Incidence;Intervention;Intervention Studies;Malignant neoplasm of prostate;men;Minority;Modeling;modifiable risk;Monitor;Morbidity - disease rate;Observational Study;Outcome;outcome disparities;Outcomes Research;Participant;Patient Outcomes Assessments;Patients;Persons;Population;prostate cancer model;prostate cancer risk;prostate cancer survivors;Protocols documentation;psychosocial;Public Health;Quality of life;racial discrimination;Recording of previous events;recruit;reduce symptoms;Reporting;Research;Research Personnel;Risk;Risk Factors;risk selection;saliva sample;Sampling;Sexual Dysfunction;Sleep disturbances;Social Environment;sociodemographics;Socioeconomic Status;Survivors;Symptom Burden;Time;Tumor stage;urinary

PROJECT_TITLE: Identifying and Reducing Disparities in Patient-Reported Outcomes Among African American Prostate Cancer Survivors

STUDY_SECTION: CMPC

STUDY_SECTION_NAME: Clinical Management of Patients in Community-based Settings Study Section[CMPC]


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: FORT WORTH

ORG_NAME: UNIVERSITY OF NORTH TEXAS HLTH SCI CTR

ORG_STATE: TX

PHR: The long-term goal of this research is to examine the link between changes in DNA methylation patterns and cognitive decline among Mexican Americans. Here we will address the aims of PAR-19-070 (Research on Current Topics in Alzheimer's Disease and Its Related Dementias) – NOT-AG-18-047 – by leveraging the ongoing HABLE cohort (R01AG054073) to identify longitudinal epigenetic factors among Mexican Americans for cognitive decline and brain imaging changes associated with dementia.

PI_NAMEs: BARBER, ROBERT CLINTON (contact)

PROGRAM_OFFICER_NAME: KING, JONATHAN W

PROJECT_TERMS: Address;Age;aging brain;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease related dementia;Alzheimer's disease risk;Alzheimer’s disease biomarker;Amyloid;Anosmia;biobank;Biological Markers;Brain imaging;brain magnetic resonance imaging;Cell Count;Cell Cycle Regulation;Cerebrum;Clinic;Cognitive;cognitive function;cohort;Collection;Communities;Consensus;Data;Databases;Dementia;Diabetes Mellitus;Diagnosis;DNA;DNA Methylation;Education;Elderly;Epigenetic Process;epigenome-wide association studies;Ethnic Origin;Etiology;exosome;Exposure to;follow-up;functional genomics;Funding;Gender;Genes;Genetic;Goals;Health;health disparity;Health Services Accessibility;hearing impairment;Hispanic Populations;Hypertension;Impaired cognition;Incidence;Individual;Inflammation;Inflammatory;innovation;Investigation;Leukocytes;lifestyle factors;Link;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Measures;medical specialties;Metabolic;Metabolic dysfunction;Metabolic stress;Methylation;methylation pattern;Mexican Americans;Nerve Degeneration;neuron loss;normal aging;Not Hispanic or Latino;Ontology;Outcome;Participant;Pathologic;Pathway Analysis;Pattern;Peripheral;Phenotype;Plasma;Population Heterogeneity;Positron-Emission Tomography;Poverty;Prevalence;Process;Proteomics;Research;Risk Factors;Role;Site;Smell Perception;Study of Latinos;Synapses;tau Proteins;Time;Work;β-amyloid burden

PROJECT_TITLE: Epigenetic Risk Factors for AD Age at Onset and Health Disparities: HABLE Epigenetics Study

STUDY_SECTION: NAME

STUDY_SECTION_NAME: Neurological, Aging and Musculoskeletal Epidemiology Study Section[NAME]


NIH_SPENDING_CATS: Aging;Assistive Technology;Bioengineering;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Pain Research;Rehabilitation

ORG_DEPT: PHYSICAL MEDICINE & REHAB

ORG_NAME: UNIVERSITY OF SOUTH FLORIDA

PHR: Project Narrative Approximately 10% of aging adults experience plantar fasciitis, with 50% of cases being disabling. Plantar fasciitis is most commonly treated with foot orthotics and supportive footwear, which have been shown to weaken the feet and can increases the risk for recurrence. The aim of this study is to determine whether improving foot strength through foot exercises and minimal footwear can provide improved outcomes over the short and long term.

PI_NAMEs: DAVIS, IRENE S (contact)

PROGRAM_OFFICER_NAME: RADZISZEWSKA, BARBARA

PROJECT_TERMS: Adult;Age;Aging;aging population;Atrophic;Chronic;comparison intervention;Cumulative Trauma Disorders;design;Disabling;Disabling condition;Drug Prescriptions;Equilibrium;Exercise;Exhibits;experience;flexibility;follow-up;foot;Foot Pain;functional outcomes;Goals;improved;improved outcome;Incidence;Individual;Intervention;Knee Osteoarthritis;Laboratories;Measures;Mental Depression;Methods;Mobility decline;Monitor;Muscle;muscle strength;Muscle Weakness;Muscular Atrophy;novel;novel strategies;older adult;Older Population;Orthotic Devices;Outcome Assessment;Outcome Measure;Pain;Participant;Patients;Physical Function;Plantar fascia structure;Plantar Fasciitis;Population;programs;Quality of life;Questionnaires;Randomized;recruit;Recurrence;Research;resilience;Resolution;Risk;Risk Reduction;Shoes;Site;standard of care;Stretching;Symptoms;Testing;Time;Training;ultrasound;Walking;walking speed

PROJECT_TITLE: A Novel Approach to Plantar Fasciitis in the Aging Population  The NAPA trial

STUDY_SECTION: MRS

STUDY_SECTION_NAME: Musculoskeletal Rehabilitation Sciences Study Section[MRS]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering

ORG_CITY: CAMBRIDGE

ORG_DEPT: CHEMISTRY

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

PHR: PROJECT NARRATIVE The discovery and development of novel small molecule pharmaceuticals depends on medicinal chemists’ ability to rapidly construct and derivatize molecular scaffolds. Though remarkable advances in transition metal- catalyzed cross-coupling have revolutionized organic synthesis within drug discovery, low thresholds for metal contamination in pharmaceutical products—as well as the susceptibility of d-block elements to coordination with medicinally relevant, polar functional groups—has fueled interest in developing alternative catalytic methods utilizing main-group elements. This proposal describes the design of novel nontrigonal phosphorous catalysts to enable the development of a medicinally-relevant C–N cross-coupling, employing both computational modeling and multidimensional analysis to guide catalyst optimization and discern key mechanistic details.

PI_NAMEs: LAVAGNINO, MARISSA NICOLE (contact)

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TITLE: Development of Novel Biphilic Phosphorus Catalysts via Computational Modeling and Multidimensional Analysis


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_NAME: BROOKLYN COLLEGE

ORG_STATE: NY

PHR: Project Narrative Current understanding of the influence of genetic and environmental factors on sweet preference are mostly based on research conducted in individuals of European ancestry, and whether these results can be generalized to people of other ancestry groups warrants investigation. Our study will determine the influence of genetics and the environment on sweet preference in two traditionally underrepresented groups. Our proposed work will advance the understanding of how genes and environment affect food preference by addressing the lack of diversity in both genetic and chemosensory research.

PI_NAMEs: CHEUNG, MAY MEIYU (contact)

PROGRAM_OFFICER_NAME: FRINCU, CRINA

PROJECT_TERMS: Accounting;Address;Adult;Affect;Africa;African;African ancestry;Alleles;Area;Asian ancestry;Asian population;Award;Beverages;biobank;Biomedical Research;Birth;Black Populations;Chronic Disease;Cities;college;Conduct Clinical Trials;Consumption;cost;cost efficient;Data;Data Set;Diet;Eating;Eligibility Determination;Environment;Environmental Risk Factor;ethnic diversity;European ancestry;Exposure to;Faculty;Food;food environment;Food Habits;Food Preferences;Frequencies;Gene Frequency;Genes;Genetic;Genetic Research;genome wide association study;Goals;Health;health disparity;Healthy Eating;hedonic;Human;Immigrant;improved;indexing;Individual;Individual Adjustment;Individual Differences;Intake;Intervention;Investigation;Linear Regressions;Measures;member;Methods;Modeling;National Institute on Deafness and Other Communication Disorders;Native-Born;New York;Not Hispanic or Latino;nutrition;Nutritional;Nutritional Science;Obesity;obesogenic;Participant;Perception;personalized nutrition;personalized strategies;Persons;Phenotype;pleasure;polygenic risk score;Population;Population Heterogeneity;Positioning Attribute;Postdoctoral Fellow;preference;Psychophysics;Questionnaires;racial diversity;Recommendation;Research;Research Personnel;response;Science;Sensory;Single Nucleotide Polymorphism;student participation;student training;Students;sugar;Surveys;Testing;Time;undergraduate student;Underrepresented Populations;Underserved Population;United States;Universities;Work

PROJECT_TITLE: Genetic and Environmental Influences on Individual Sweet Preference Across Ancestry Groups in the U.S.


NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_CITY: SAN DIEGO

ORG_NAME: CALIFORNIA MEDICAL INNOVATIONS INSTITUTE

PHR: NARRATIVE Coronary heart disease is one of the most important health problems in Western society today. The principal mechanism in this problem is insufficient blood supply to the heart muscle. The objective of this proposal is to understand the distribution of blood flow in the heart using an experimentally-validated biophysical model to enable therapeutics for treatment.

PI_NAMEs: KASSAB, GHASSAN S (contact);LEE, LIK CHUAN

PROJECT_TERMS: 3-Dimensional;Acute;Address;Affect;ameroid;Anatomy;animal data;Animals;Balloon Occlusion;Biological;biophysical model;Blood capillaries;Blood flow;Blood Vessels;Cardiac;Chronic;clinical practice;Clinical Research;clinically relevant;clinically significant;computer framework;Computer Models;Consumption;Coronary;Coronary Arteriosclerosis;Coronary Circulation;Coronary heart disease;Coronary sinus structure;Coronary Stenosis;coronary vasculature;Coupling;Data;Diagnosis;Diffuse;Disease;effective therapy;Effectiveness;experimental study;Family suidae;Foundations;Genes;Health;Heart;Heterogeneity;High Performance Computing;Homeostasis;in vivo;Intervention;Ischemia;Knowledge;Length;Liquid substance;mathematical model;Measurement;Mechanics;Medical Imaging;Metabolic;Modeling;Morphology;Myocardial;Myocardium;Nature;novel;Organ;Outcome;Oxygen;Oxygen Consumption;Pathologic;Patient Selection;Patients;Percutaneous Transluminal Coronary Angioplasty;Perfusion;Physics;porcine model;pressure;Property;Refractory;Regional Blood Flow;regional difference;restraint;Risk;Role;Scientific Advances and Accomplishments;Societies;Solid;theories;Therapeutic;Time;Tissues;Translating;Treatment Effectiveness;treatment optimization;Trees;Vascular blood supply;Vascular System;Venous;Work

PROJECT_TITLE: Mechanisms of coronary flow heterogeneity: Implications for coronary sinus occlusion therapy

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Cost Effectiveness Research;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Mental Health;Patient Safety;Prevention;Sexually Transmitted Infections;Women's Health Research

ORG_CITY: BALTIMORE

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Our long-term goal is to increase HIV prevention knowledge and care delivery by ObGyns in priority jurisdictions for the Ending the HIV Epidemic in the U.S. by using an existing electronic health record technology. We will implement a multi-level (patient and provider-level), multi-component intervention. Our primary outcomes will determine 1) the most effective intervention and evaluate its implementation in an ObGyn clinical setting, and 2) which study arm has the highest PrEP uptake.

PI_NAMEs: COLEMAN, JENELL S (contact);MMEJE, OKEOMA O.

PROGRAM_OFFICER_NAME: GORDON, CHRISTOPHER M

PROJECT_TERMS: AIDS prevention;animation;arm;Assessment tool;Baltimore;Black race;black women;budget impact;care delivery;Caring;cis-female;Cities;Clinic;Clinical;clinical care;Clinical Trials;Collaborations;Communication;computerized;condoms;consistent condom use;contextual factors;cost;cost-effectiveness evaluation;Counseling;Data Collection;Disclosure;disease transmission;Disproportionately impacts women;Education;effective intervention;effectiveness-implementation RCT;Electronic Health Record;Electronics;Eligibility Determination;emtricitabine;Epidemic;Equity;Evidence based intervention;Female;Fumarates;Funding;Goals;Health Benefit;Health system;Heterosexuals;high risk;HIV;HIV Infections;HIV risk;Human immunodeficiency virus test;Hybrids;implementation strategy;improved;Incidence;Intervention;Investments;Knowledge;Local Government;male;Marketing;Maryland;Medicaid;medical specialties;men;men who have sex with men;Methods;multi-component intervention;Multimedia;Office Visits;Oral;patient population;patient-level barriers;Patients;Population;pre-exposure prophylaxis;preference;Prenatal care;Prevalence;prevention service;primary outcome;Provider;provider intervention;provider-level barriers;Public Health;Randomized;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recording of previous events;Reporting;Reproductive Health Services;Risk;Risk Assessment;Risk Factors;risk perception;Self Administration;service delivery;sex;sexual and reproductive health;sexually active;Sexually Transmitted Diseases;Site;socioeconomic disadvantage;standard of care;Surveys;Technology;Tenofovir;Time;tool;United States;United States Health Resources and Services Administration;uptake;Woman;women patients;women versus men

PROJECT_TITLE: Improving HIV Prevention Services among Socioeconomically Disadvantaged Cis-gender Women


NIH_SPENDING_CATS: Genetics

ORG_CITY: NEW HAVEN

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative Chemical modiﬁcations on mRNA are a critical mechanism of gene expression regulation via their eﬀects on RNA transcription, processing, and translation. Loss of these chemical marks can result in developmental defects and diseases, including cancer and neurodegenerative disease, but the molecular mechanisms that regulate them are often unclear. This proposal will use innovative new biochemical approaches to elucidate the functions of new mRNA modiﬁcations, and the regulatory mechanisms that govern their cotranscriptional deposition.

PI_NAMEs: NACHTERGAELE, SIGRID H (contact)

PROGRAM_OFFICER_NAME: VATAKIS, DIMITRIOS NIKOLAOS

PROJECT_TERMS: Address;Area;Biochemical;Biochemistry;Biological Models;Biology;Cells;Chemicals;Complex;Data;Defect;Deposition;Development;Disease;Enzymes;Gene Expression Regulation;Genetic Transcription;Glean;High-Throughput Nucleotide Sequencing;human disease;innovation;Label;Laboratories;Malignant Neoplasms;Maps;Mediating;Messenger RNA;Methods;Methylation;Modification;Molecular;molecular modeling;Neurodegenerative Disorders;Positioning Attribute;Postdoctoral Fellow;Prevalence;prevent;recruit;Regulation;Research;RNA;RNA methylation;RNA Polymerase II;RNA Processing;RNA Splicing;Site;System;trafficking;Transcript;transcriptome;Translations;Work

PROJECT_TITLE: Uncovering the regulatory principles of dynamic mRNA methylation

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


NIH_SPENDING_CATS: Clinical Research;Immunotherapy;Kidney Disease;Organ Transplantation;Transplantation

ORG_CITY: ATLANTA

ORG_DEPT: SURGERY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Transplantation is a cure for end stage organ failure, yet achieving “one transplant for life” remains elusive for many transplant recipients due to immunologic rejection. Studies in experimental models and patient populations have consistently implicated memory T cells as playing a causal role in mediating immunosuppression-resistant allograft rejection; thus, the identification of the molecular mechanisms that regulate memory T cells responses remains an important goal for immunotherapy in clinical transplantation. Through the mechanistic and translational studies proposed in this grant, we will elucidate fundamental molecular and cellular pathways controlling CD8+ T cell responses, and their therapeutic potential to attenuate memory CD8+ T cell responses and improve outcomes in clinical transplantation.

PI_NAMEs: FORD, MANDY L (contact)

PROGRAM_OFFICER_NAME: KEHN, PATRICIA J

PROJECT_TERMS: Acceleration;Acute;Address;allograft rejection;Antibodies;Apoptosis;Attenuated;Automobile Driving;B-Lymphocytes;CASP3 gene;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Death;Cell Separation;Cells;Clinical;Clinical Trials;clinically relevant;cohort;cytokine;Data;Development;end-stage organ failure;Enzymes;Equilibrium;Exhibits;Experimental Models;experimental study;Fc Receptor;Fibrinogen;FOXP3 gene;Freedom;Funding;Gangliosides;Gene Expression Profiling;Goals;Graft Rejection;Grant;Human;Immune;immune activation;Immune system;Immunity;Immunologics;immunoregulation;Immunosuppression;Immunotherapy;improved outcome;in vivo;Induction of Apoptosis;isoimmunity;kidney allograft;Kidney Transplantation;Knowledge;Life;Ligands;Ligation;Measures;Mediating;Memory;Messenger RNA;Metabolic;Metabolism;Modeling;Molecular;mouse model;Mus;nonhuman primate;novel;novel therapeutics;Organ;Organ Transplantation;Outcome;Paper;Pathway interactions;patient population;Patients;Peripheral Blood Mononuclear Cell;Play;predictive marker;Proteins;Proteomics;receptor;Receptor Signaling;Regulation;Regulatory Pathway;Regulatory T-Lymphocyte;Resistance;response;retransplantation;risk stratification;Role;Seminal;Series;Signal Pathway;Signal Transduction;Signaling Molecule;skin allograft;Source;Surface;T cell response;T memory cell;T-Cell Activation;T-Lymphocyte;Tacrolimus;Testing;Therapeutic;Therapeutic Intervention;transcriptome sequencing;translational study;Transplant Recipients;Transplantation;Transplantation Tolerance;Validation;Waiting Lists;Weaning

PROJECT_TITLE: Determinants of T Cell Fate in Transplantation Tolerance

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIB-J(02)]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research

ORG_CITY: IRVINE

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

ORG_STATE: CA

PHR: Project Narrative Underrepresentation of Hispanics/Latinos in preclinical Alzheimer’s disease (AD) trials limits our ability to evaluate potential differences in treatment effects as well as adverse events by race/ethnicity and reduces the generalizability of study findings. Potential barriers to AD trial participation among Hispanics/Latinos may be multifactorial and remain poorly understood. We propose to use an Intervention Mapping approach to systematically identify key behavioral determinants of participation and develop an evidence-base behavioral intervention designed to improve Hispanic/Latino willingness to participate in preclinical AD trials.

PI_NAMEs: SALAZAR, CHRISTIAN R (contact)

PROGRAM_OFFICER_NAME: BANDIERA, FRANK

PROJECT_TERMS: Active Learning;Address;Adult;Adverse event;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Attitude;Behavior Therapy;Behavioral;Belief;Biological Markers;California;Clinical Research;clinical trial recruitment;Cognitive;cognitive interview;Communities;community based research;contextual factors;Data;Decision Making;Dedications;design;Disparity;Enrollment;Ensure;Epidemiologist;Ethnic Origin;evidence base;experience;Fellowship;Foundations;Funding;Goals;Grant;Health;Health Disparities Research;health literacy;Healthcare Systems;Hispanic;Hispanic Populations;improved;Individual;Infrastructure;innovation;insight;Instruction;Intention;Internet;Intervention;intervention mapping;K-Series Research Career Programs;Knowledge;Latino;Latino Population;Leadership;Linguistics;literacy;Literature;Mentors;Mentorship;Methods;Minority Recruitment;Modeling;Multicenter Studies;Multicenter Trials;Not Hispanic or Latino;novel;older adult;Participant;Persons;pilot test;Population;population based;Positioning Attribute;pre-clinical;preclinical trial;Process;Race;Randomized;randomized, clinical trials;Recommendation;recruit;recruitment science;Registries;Research;Research Personnel;Resources;risk perception;Safety;Sampling;Science;Scientist;skills;Solid;Surveys;Testing;therapy design;Training;treatment effect;Treatment Efficacy;Underrepresented Populations;Underserved Population;United States National Institutes of Health;University resources;willingness;Work

PROJECT_TITLE: Improving Hispanic/Latino participation in preclinical Alzheimers disease Trials

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development For Early Career Investigators Study Section [AGCD-2]


NIH_SPENDING_CATS: Biotechnology;Genetics;Neurosciences;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Spinal Cord Injury;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Traumatic Head and Spine Injury

ORG_CITY: AUGUSTA

ORG_DEPT: NEUROSCIENCES

ORG_NAME: AUGUSTA UNIVERSITY

PHR: Project Narrative: In vivo neuronal reprogramming is emerging as a potentially new breakthrough in regenerative medicine. This proposal will examine microRNA function during NeuroD1-mediated neuronal reprogramming in a mouse model of spinal cord injury (SCI) and determine neuronal reprogramming by microRNAs for treating SCI.

PI_NAMEs: LI, HEDONG  (contact)

PROGRAM_OFFICER_NAME: BAMBRICK, LINDA LOUISE

PROJECT_TERMS: Alzheimer's disease model;Animal Behavior;Animals;Astrocytes;Base Pairing;Behavioral;Behavioral Assay;Brain;Brain Injuries;Bypass;cell replacement therapy;Cells;chemical synthesis;Clinical Trials;Cues;Disease;Environment;Ethical Issues;Exhibits;experience;Foundations;Future;Gene Expression;Gene Expression Profile;Genes;Glutamates;Goals;improved;In Situ;in vivo;Induced Neurons;Injury;innovative technologies;Knock-out;Laboratories;Mediating;MicroRNAs;miRNA expression profiling;Modeling;Molecular;mouse model;Nervous System Disorder;neurodevelopment;Neuroglia;neuronal circuitry;Neurons;novel therapeutics;Nucleotides;overexpression;Penetration;Phenotype;Play;Process;programs;reconstruction;Recovery;Recovery of Function;Regenerative Medicine;repaired;Research;Role;Signal Pathway;Slice;Small RNA;Spinal Cord;Spinal cord injury;Spinal cord injury patients;spinal cord repair;stem cell replacement;Stem cell transplant;stem cells;synthetic drug;Technology;Therapeutic;Tissues;Transcription Coactivator;transcription factor;transcriptome sequencing;transplantation therapy;Untranslated RNA

PROJECT_TITLE: MicroRNA Function During Neuronal Reprogramming in Treating Spinal Cord Injury

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


NIH_SPENDING_CATS: Biomedical Imaging;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Neurosciences;Prevention

PHR: Project Narrative: Chronic hyperglycemia has been associated with a decrease in brain glucose transport through down-regulation of GLUT1 at the blood brain barrier, findings that could be explained as a protective adaptation of the central nervous system against the harmful consequences of hyperglycemia. However, GLUT1 down regulation may lead to reduced brain glucose metabolism leading to neuronal damage, neurodegeneration and cognitive decline. This application will determine whether improvement of glycemic control in poorly controlled type 2 diabetic subjects would restore glucose brain transport kinetics by using classic metabolic studies methodology as well as state-of-the-art brain nuclear magnetic resonance spectroscopy (MRS) techniques.

PI_NAMEs: SANCHEZ RANGEL, ELIZABETH  (contact)

PROGRAM_OFFICER_NAME: WOO, THERESA TESLOVICH

PROJECT_TERMS: 3-Dimensional;Acute;Age;Animals;Area;Blood - brain barrier anatomy;blood glucose regulation;Brain;brain dysfunction;Brain region;cell injury;Central Nervous System;Cerebrum;Chronic;Citric Acid Cycle;Closure by clamp;cognitive change;Consumption;Data;design;Deuterium;Diabetes Mellitus;diabetes mellitus therapy;Down-Regulation;Energy Metabolism;Energy-Generating Resources;experience;Exposure to;Feasibility Studies;Funding;Future;Glucose;Glucose Clamp;glucose metabolism;glucose transport;Glucose Transporter;Glutamates;Glutamine;glycemic control;Glycosylated hemoglobin A;Goals;gray matter;healthy weight;Human;Hyperglycemia;Image;Impaired cognition;improved;Individual;Intervention;Intravenous infusion procedures;Kinetics;Label;Light;magnetic resonance spectroscopic imaging;Magnetic Resonance Spectroscopy;Maps;Measurement;Measures;Mentors;Metabolic;metabolic abnormality assessment;metabolic imaging;Methodological Studies;Methodology;Methods;Morbidity - disease rate;mortality;Nerve Degeneration;Neurons;NMR Spectroscopy;non-diabetic;Non-Insulin-Dependent Diabetes Mellitus;novel;Occipital lobe;Participant;Patients;Peripheral;Physiological;Pilot Projects;Plasma;Play;post intervention;Prefrontal Cortex;Prevalence;prevent;Protons;Reporting;response;Sample Size;SLC2A1 gene;Techniques;Testing;Training;Type 2 diabetic

PROJECT_TITLE: Reversibility of brain glucose kinetics in type 2 diabetic subjects

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Narrative The Mechanisms of Virus-Host Interactions Training Grant is vital to the development of the next generation of virologists. The trainees will be leaders in the field of Virology developing strategies to prevent and limit virus pathogensis.

PI_NAMEs: TORTORELLA, DOMENICO  (contact)

PROGRAM_OFFICER_NAME: SASTALLA, INKA I

PROJECT_TERMS: Training Programs;virus host interaction

PROJECT_TITLE: Training Program in Mechanisms of Virus-Host Interactions

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases B Research Study Section[MID-B]


NIH_SPENDING_CATS: Chronic Pain;Lymphatic Research;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine

ORG_CITY: CINCINNATI

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF CINCINNATI

PHR: Chronic pain conditions such as complex regional pain syndrome (CRPS) are common, long-lasting, and debilitating. We propose to continue the study of the sympathetic component of pathological pain by testing novel mechanisms of action. Specifically, using mouse and rat models, we will determine how sympathetic innervation mediates pain by regulating cell death, nerve regeneration, and by interactions with the lymphatic system especially the adjacent lymph nodes.

PI_NAMEs: ZHANG, JUN-MING  (contact)

PROGRAM_OFFICER_NAME: GREENWELL, THOMAS

PROJECT_TERMS: activating transcription factor 3;Adrenergic Fibers;Adrenergic Receptor;Affect;Afferent Neurons;Animal Model;Animals;axon regeneration;behavior measurement;Catheters;Cell Death;Cell Survival;Cessation of life;chronic painful condition;Clinic;Clinical;Clinical Research;Complex Regional Pain Syndromes;cost;Data;density;Development;effective therapy;experimental study;Generations;genetic manipulation;Hypersensitivity;Immune;Immune response;Immunohistochemistry;immunoregulation;in vivo imaging;Incidence;Induced Neurons;Inflammation;Inflammatory Response;Injections;Ipsilateral;knock-down;Knock-in Mouse;Label;lymph nodes;Lymphatic System;Macrophage;Macrophage Activation;Measures;Mediating;Modeling;Molecular Biology;Morbidity - disease rate;mouse model;Mus;Natural regeneration;Nerve;Nerve Cell Survival;nerve injury;Nerve Regeneration;nerve supply;neuron loss;neuron regeneration;neuronal survival;Neurons;neuroprotection;Norepinephrine;novel;novel therapeutic intervention;Pain;pain behavior;pain reduction;pain sensitivity;painful neuropathy;Pathologic;Patients;Peripheral nerve injury;pharmacologic;Phenotype;Physiological;pre-clinical;Process;Rattus;reinnervation;Reporting;Role;sensor;Sensory Ganglia;Spinal Ganglia;Sympathectomy;Sympathetic Nervous System;System;Techniques;Testing;Time

PROJECT_TITLE: Study of Activity-Dependent Sympathetic Sprouting

STUDY_SECTION: NPI

STUDY_SECTION_NAME: Neurobiology of Pain and Itch Study Section [NPI]


ORG_CITY: WEST LAFAYETTE

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: NARRATIVE This program will develop innovative synthetic methods and strategies for accessing fluorinated substructures commonly found in marketed drugs, therapeutic candidates, and biological probes. Further, the program will computationally and experimentally validate physicochemical and biophysical perturbations imparted by fluorinated substructures with the goal of delivering next-generation fluorinated therapeutic candidates with improved drug-like properties.

PI_NAMEs: ALTMAN, RYAN A (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TERMS: Affect;Alcohols;Alkenes;analog;Area;Biological;Biophysics;catalyst;design;Development;Drug Kinetics;drug market;Drug Stability;Electrochemistry;functional group;Goals;improved;In Vitro;in vivo;innovation;Ligands;Medicine;metabolic profile;Metabolism;Methodology;Methods;Modernization;Natural Products;next generation;novel therapeutics;Parents;Pharmaceutical Chemistry;Pharmaceutical Preparations;Pharmacodynamics;Phase;physical property;programs;Property;Proteins;Reaction;Reagent;Synthesis Chemistry;System;Therapeutic;therapeutic candidate;Transition Elements;Work

PROJECT_TITLE: Fluorination and Fluoroalkylation Strategies for Synthetic and Medicinal Chemistry


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Pediatric;Rural Health;Social Determinants of Health

ORG_CITY: FAYETTEVILLE

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF ARKANSAS AT FAYETTEVILLE

ORG_STATE: AR

PHR: PROJECT NARRATIVE An objective of this proposal is to provide on-campus STEAM laboratory, education, and research experience to 400 low-income, racially diverse middle school students and 15 STEAM teachers from the Dumas, Arkansas public school system. The project is significant because it will introduce the students to different STEAM and STEAM-related fields and to the amenities at the University of Arkansas- Fayetteville (UA), with the intent to foster a desire to pursue a (a) career in Science, Technology, Engineering, Art and Mathematics or STEAM- related fields, (b) commitment to improved public health, and (c) college education at UA or another university. We will also offer a STEAM Teacher Training Program for Dumas Public School STEAM teachers each year and incorporate an innovative Child Savings Account (CSA) college savings program for all youth participants, with seed deposits of $50 and regular financial education classes for students, parents, and siblings.

PI_NAMEs: CHEEK, LEAH ;DAUGHERTY, MICHAEL K;MURPHY-ERBY, YVETTE ;SHOBE, MARCIA ANNE (contact)

PROGRAM_OFFICER_NAME: FAUPEL-BADGER, JESSICA

PROJECT_TERMS: Academic achievement;Acclimatization;Affect;African American;African American student;Area;Arkansas;Awareness;Behavior;Biology;Budgets;career;Career Choice;Child;college;Communities;Control Groups;Deposition;design;Discipline;Economic Development;Education;Educational Curriculum;Educational process of instructing;elementary school;Engineering;engineering design;Enrollment;Exercise;experience;Faculty;faculty mentor;Family;financial literacy;Financial Support;fitness;Focus Groups;Fostering;Foundations;Funding;Future;Gender;Gifts;Goals;graduate student;Graduation Rates;Grant;Habits;health disparity;high school;Hour;improved;innovation;Institution;interest;Kinesiology;Knowledge;Laboratories;Lead;Learning;learning strategy;Life;Low income;Mathematics;Measures;member;Mentors;Methodology;Methods;Middle School Student;Molecular Chaperones;ninth grade;operation;Outcome Measure;outreach;Parents;Participant;Pathway interactions;peer coaching;people of color;Performance;Personal Satisfaction;Pilot Projects;Population;Problem Solving;Process;Professional counselor;programs;project-based learning;Public Health;racial diversity;Readiness;recruit;Research;Research Project Grants;Rural;rural African American;Savings;Schedule;school district;Schools;Science;Siblings;sixth grade;social;social media;Social Problems;Social Work;socioeconomics;Steam;STEM field;STEM program;Students;success;summer program;Surveys;System;teacher;Teacher Professional Development;Teaching Method;Technology;Time;Training;Training and Education;Training Programs;undergraduate student;Underrepresented Minority;underrepresented minority student;Underrepresented Students;Universities;University resources;university student;volunteer;Women's Group;Youth

PROJECT_TITLE: STEAM Education and Training for Underrepresented Students and Teachers in the Arkansas Delta

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-H(55)R]


ADMINISTERING_IC: HD

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: PROJECT NARRATIVE – OVERALL The proposed IDDRC will support a translational science agenda focused on intellectual and developmental disabilities (IDDs). The IDDRC will integrate research from multiple disciplines and bridge basic and clinical science with the support of dynamic and cutting-edge scientific cores to arrive at treatments for IDDs. The IDDRC’s partnerships locally and nationally, and robust dissemination plan will ensure its discoveries improve the lives of individuals with IDD and their families.

PI_NAMEs: ABBEDUTO, LEONARD J.;BAUMAN, MELISSA DAWN;VAN DE WATER, JUDY A. (contact)

PROGRAM_OFFICER_NAME: PARISI, MELISSA

PROJECT_TERMS: Acceleration;Address;Affect;Angelman Syndrome;Antibodies;Area;associated symptom;Attention deficit hyperactivity disorder;autism spectrum disorder;autism symptoms;Basic Science;Behavior;Behavior Therapy;Behavioral;biobehavior;Bioinformatics;Biological;Biological Assay;Biological Markers;Biological Models;Biological Response Modifier Therapy;biomarker development;Biometry;brain abnormalities;California;catalyst;cellular imaging;Child;Chromosomes;Clinical;clinical care;Clinical Data;Clinical Sciences;clinical translation;cohort;college;Communication;Communities;comorbidity;Complex;cost effective;Data;Development;Diagnosis;DiGeorge Syndrome;digital technology;Discipline;disorder risk;Down's Syndrome;drug efficacy;Education;electronic data;Ensure;Environmental Exposure;Epigenetic Process;evidence base;Exposure to;Faculty;Family;FMR1 gene;Fostering;Fragile X Syndrome;Funding;gene environment interaction;Genetic;Genetic Predisposition to Disease;health care disparity;Heterogeneity;high risk;Home;Human;immune function;Immune System Diseases;improved;Individual;innovation;insight;Intellectual and Developmental Disabilities Research Centers;Intellectual functioning disability;interdisciplinary collaboration;International;Intervention;Leadership;Maternal autoantibody;Measures;Medical center;medication safety;Modeling;Molecular Analysis;molecular imaging;Mothers;multidimensional data;Mus;mutant;National Institute of Child Health and Human Development;Nature;neurodevelopment;Neuroimmune;operation;Outcome;Outcome Measure;outreach;Participant;Pathway interactions;Peer Review;Persons;Phenotype;Policy Maker;Preclinical Drug Evaluation;Pregnancy;prevent;Prevention approach;Process;programs;Rattus;recruit;Reduce health disparities;Research;Research Design;Research Personnel;Research Project Grants;Resources;Risk;Rodent;Rodent Model;Role;Route;Sampling;Schools;Science;Services;Site;social disparities;Source;Statistical Data Interpretation;Symptoms;Systems Analysis;Technology;Teratogens;Testing;Training;Translational Research;Treatment Efficacy;United States National Institutes of Health;Universities

PROJECT_TITLE: MIND Institute Intellectual and Developmental Disabilities Research Center


NIH_SPENDING_CATS: Brain Disorders;Disability Research;Down Syndrome;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric;Rare Diseases

PI_NAMEs: ABBEDUTO, LEONARD J. (contact)

PROJECT_TERMS: Acceleration;Address;Adult;Angelman Syndrome;Attention deficit hyperactivity disorder;autism spectrum disorder;Behavioral;biobehavior;California;career;Communities;Conceptions;cost effective;Development;DiGeorge Syndrome;Disability research;Doctor of Philosophy;Down's Syndrome;Educational Activities;Ensure;Environmental Risk Factor;Equity;Family;Fragile X Syndrome;Funding;genetic risk factor;Individual;innovation;Intellectual and Developmental Disabilities Research Centers;Intellectual functioning disability;interdisciplinary collaboration;Leadership;life span;Methods;Monitor;Procedures;programs;Quality of life;recruit;Research;Research Infrastructure;Research Personnel;Research Project Grants;Resources;Science;Scientist;Secure;Services;Technology;Translational Research;Translations;Universities

PROJECT_TITLE: Core A. Administrative Core


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Down Syndrome;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Rare Diseases

PI_NAMEs: OZONOFF, SALLY  (contact)

PROJECT_TERMS: Address;Age;autism spectrum disorder;Behavioral;biobehavior;Biological;California;Characteristics;Childhood;Clinical;clinical translation;Clinical Trials;Collection;community engagement;community engagement process;comorbidity;comparison group;cost;cost effective treatment;cost effectiveness;design;Diagnostic;DiGeorge Syndrome;Dimensions;Disease;Doctor of Philosophy;Down's Syndrome;Economics;Ensure;Ethnic Origin;Evaluation;experience;Failure;Fragile X Syndrome;Funding;Genetic;Genomic medicine;Genomics;Health;Health Technology;Heterogeneity;Human;improved;Incentives;inclusion criteria;Individual;Infrastructure;innovation;instrument;Intellectual and Developmental Disabilities Research Centers;interest;Investigation;Libraries;Link;Maps;Measures;Methodology;Molecular Analysis;Monitor;Mood Disorders;Names;National Institute of Child Health and Human Development;neurobehavioral;neuropathology;Participant;patient engagement;Patient Recruitments;Phenotype;Population;Process;Productivity;programs;psychologic;Qualifying;Race;recruit;Registries;Research;Research Personnel;Resources;Science;Scientist;Services;Site;Standardization;standardize measure;Symptoms;Syndrome;Technology;telehealth;Testing;tool;Training;Translations;Universities;Variant;Venous blood sampling

PROJECT_TITLE: Core B. Clinical Translational Core


NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Neurosciences

ORG_CITY: PITTSBURGH

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative Fear is an essential adaptive mechanism for interacting with a changing environment, but fear can be maladaptive when it overgeneralizes, leading to distressing and intrusive defensive reactions in objectively safe situations. This is a common feature in anxiety and trauma-related disorders, for which current treatments provide at most minimal symptom relief in a third of affected patients. This research proposal will identify the neural circuit activity underlying fear discrimination, with the long-term goal of advancing the development of new treatments for anxiety and trauma-related disorders.

PI_NAMEs: STUJENSKE, JOSEPH MATTHEW (contact)

PROGRAM_OFFICER_NAME: DRISCOLL, JAMIE DANIELLE

PROJECT_TERMS: Adult;Advanced Development;Affect;Agonist;Amygdaloid structure;Anti-Anxiety Agents;Anxiety;Anxiety Disorders;anxiety treatment;Behavior;Behavioral;Brain;burden of illness;Calcium;career;career development;cell cortex;Cell Surface Receptors;cell type;Cells;Chronic;clinical training;Code;comorbidity;conditioned fear;conditioning;Cues;Data;Diagnostic;differential expression;Discrimination;Discrimination Learning;Disease;Disinhibition;Distress;Dorsal;effective therapy;Environment;Equilibrium;Exhibits;experimental study;Extinction;extracellular;Feedback;flexibility;Fright;Functional Magnetic Resonance Imaging;G-Protein-Coupled Receptors;Glutamates;Goals;Health Care Costs;high dimensionality;Human;Image;Impaired cognition;in vivo;Infusion procedures;insight;instructor;Interneurons;Learning;learning extinction;Ligands;Long-Term Depression;Medial;Mediating;Medical center;Mental Depression;Mental disorders;Mentorship;metabotropic glutamate receptor 2;metabotropic glutamate receptor 3;neural;neural circuit;Neurons;neurophysiology;neuroregulation;novel;novel therapeutics;optogenetics;Output;pandemic disease;Patients;Pharmaceutical Preparations;pharmacologic;Physicians;Physiology;Population;Positioning Attribute;Post-Traumatic Stress Disorders;Prefrontal Cortex;presynaptic;Presynaptic Terminals;prevent;Program Development;Property;Psychiatry;Pyramidal Cells;Reaction;reduce symptoms;Refractory;Reporting;Research;Research Proposals;Research Training;response;Role;Safety;Scientist;Shapes;Signal Transduction;skills;Specificity;Stimulus;Stress;Synapses;temporal measurement;Testing;Therapeutic;Therapeutic Agents;therapeutic development;therapeutic target;tool;Training;Trauma;two-dimensional;two-photon;Work

PROJECT_TITLE: Encoding of fear and safety discrimination in prefrontal-amygdala projections

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: The Human Pancreas Analysis Program for Type 1 Diabetes (HPAP-T1D) Narrative Recent decades have seen a dramatic improvement in our ability to phenotype and molecularly profile human tissues relevant to the etiology of type 1 diabetes with unprecedented resolution, at the genomic, epigenomic, protein, and functional level. Here, we propose to employ state-of-the-art technologies to determine multiple aspects of pancreas and lymphoid organ biology as it pertains to type 1 diabetes and pre-diabetes. This comprehensive profiling of the natural history of type 1 diabetes will pave the way for future discoveries of disease pathogenesis as well as new treatment modalities for preventing/curing the disease.

PI_NAMEs: ATKINSON, MARK A.;KAESTNER, KLAUS H;NAJI, ALI  (contact);POWERS, ALVIN C;SGOURAKIS, NIKOLAOS

PROGRAM_OFFICER_NAME: BASU, RAJATAVA

PROJECT_TERMS: Acceleration;Age;Alpha Cell;analytical tool;Anatomy;Antibodies;Antigens;Architecture;Archives;ATAC-seq;Atlases;Autoantibodies;B-Lymphocytes;Beta Cell;biobank;Bioenergetics;Biological Assay;Biology;Blood;CD8-Positive T-Lymphocytes;Cell Communication;Cell Physiology;cell type;Cells;Characteristics;Collaborations;Collection;Computational Biology;Cytometry;Data;Data Analyses;data integration;data modalities;Data Science;Data Set;data tools;Databases;Deposition;design;Development;Diabetes Mellitus;diabetes pathogenesis;Disease;DNA;draining lymph node;Endocrine;Epigenetic Process;epigenome;epigenomics;Epithelial Cells;Etiology;experience;Florida;Flow Cytometry;Fostering;Frequencies;Future;Gene Expression Profile;Genetic Risk;genome sequencing;Genomics;Glucagon;Head;hemodynamics;high risk;Histology;Hormone secretion;Human;human tissue;Image;imaging modality;Immune;Immunobiology;Immunologics;Impairment;improved;innovation;Institution;Insulin;Insulin-Dependent Diabetes Mellitus;Intestines;islet;Islet Cell;Islets of Langerhans;Laboratories;Lamina Propria;Leadership;lymph nodes;Lymphocyte;Lymphoid;lymphoid organ;Measurement;Medical;Medical History;Metabolic;metabolic profile;Metabolism;methylome;Modality;Molecular;Molecular Profiling;multidisciplinary;National Institute of Diabetes and Digestive and Kidney Diseases;Natural History;non-diabetic;Non-Insulin-Dependent Diabetes Mellitus;novel imaging technology;Organ;Organ Donor;outreach;Oxygen Consumption;Pancreas;pancreatic juice;Pathogenesis;peripheral blood;Persons;Phase;Phenotype;Physiological;Population;Prediabetes syndrome;prevent;Process;programs;Proteins;public database;Qualifying;Recovery;release of sequestered calcium ion into cytoplasm;Research;Research Personnel;Residual state;Resolution;Resources;Sampling;Series;Serology;Signal Transduction;single cell analysis;single cell ATAC-seq;single-cell RNA sequencing;Sorting;spectrograph;Spleen;Stains;success;T-Lymphocyte;T-Lymphocyte Subsets;Tail;Team Process;Technology;Tissues;transcriptome;transcriptome sequencing;transcriptomics;United States National Institutes of Health;Universities;Visualization;web interface;web page;web site;whole genome

PROJECT_TITLE: Human Pancreas Analysis Program for Type 1 Diabetes - HPAP-T1D


NIH_SPENDING_CATS: Autism;Autoimmune Disease;Behavioral and Social Science;Brain Disorders;Clinical Research;Down Syndrome;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Pregnancy;Prevention

PI_NAMEs: VAN DE WATER, JUDY A. (contact)

PROJECT_TERMS: Address;Adjustment Disorders;Affect;Age;Anatomy;Animals;Antibodies;Antigens;Area;autism spectrum disorder;autism symptoms;autistic children;Autoantibodies;Autoantigens;Behavior;Behavioral;Bioinformatics;Biological;Biological Markers;Biological Models;biomarker development;Biometry;Brain;cell type;Child;Clinical;Clinical Research;clinical translation;clinically relevant;Cognitive;cohort;comorbidity;Complex;Data;Development;Developmental Gene;Diagnosis;differential expression;disorder risk;Early identification;Embryo;Environment;epidemiology study;Epitopes;Exhibits;experience;Experimental Models;Exposure to;fetal;Fetus;Foundations;frontal lobe;Funding;Future;Gene Expression;Glial Fibrillary Acidic Protein;high reward;high risk;High-Risk Pregnancy;Human;Immune;Immunohistochemistry;Impairment;improved;Individual;individualized medicine;Intellectual and Developmental Disabilities Research Centers;Intellectual functioning disability;Intervention;Label;Link;Maternal autoantibody;Measures;Modeling;Molecular;Molecular Analysis;Mothers;mouse model;Mus;Neuroanatomy;neurodevelopment;Neurodevelopmental Disorder;next generation;nonhuman primate;notch protein;novel strategies;novel therapeutics;offspring;Outcome;Outcome Measure;pathogenic autoantibodies;Pathogenicity;Pathologic;Pathology;Pathway interactions;Pattern;Phenotype;PIK3CG gene;Pilot Projects;Placenta;Population;Positioning Attribute;postnatal;pre-clinical;Pre-Clinical Model;preclinical study;Pregnancy;prenatal;prenatal exposure;prevent;Prevention strategy;prospective;Proteins;Rattus;repetitive behavior;Research;Research Design;Research Project Grants;Research Project Summaries;Risk;Risk Factors;Rodent;Sampling;Sensitivity and Specificity;Signal Transduction;single-cell RNA sequencing;social;Social Behavior;Specificity;targeted treatment;Testing;Therapeutic Intervention;Time;Transcript;transcriptome sequencing;transcriptomics;treatment research;United States

PROJECT_TITLE: Research Project: Pathologic Significance of Maternal Autoantibodies


NIH_SPENDING_CATS: Autism;Brain Disorders;Down Syndrome;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric

PROJECT_TERMS: Acceleration;Achievement;Address;Area;autism spectrum disorder;Autoimmune Diseases;Behavioral;Biological;Biological Assay;Biology;Brain;California;Cell Surface Receptors;cellular imaging;clinical heterogeneity;Communicable Diseases;comorbidity;Constitution;Core Facility;design;Development;Disability research;Doctor of Philosophy;Down's Syndrome;Education;Educational workshop;efficacious treatment;Ensure;Environmental Risk Factor;epigenomics;Fragile X Syndrome;Functional disorder;Funding;Genes;genetic risk factor;Genome;Genomics;Goals;Image;Immune;Immune system;Immunologics;Immunology;Individual;individualized medicine;Information Systems;Intellectual and Developmental Disabilities Research Centers;Intellectual functioning disability;interdisciplinary approach;interest;Knowledge;Malignant Neoplasms;Mentors;Methodology;Methods;Molecular;Molecular Analysis;molecular imaging;Mus;Nervous System;Neurodevelopmental Disability;neuroimmunology;Neurologic;Play;Pneumonia;Positioning Attribute;Procedures;programs;Protocols documentation;regenerative;Research;Research Personnel;research study;Resources;response;Risk;Role;senior faculty;Series;Services;Signal Pathway;stem cells;Students;System;Systems Development;Technology;Training;Universities;Water

PROJECT_TITLE: Core C. Biological and Molecular Analysis Core


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Disability Research;Down Syndrome;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Rare Diseases

PI_NAMEs: CRAWLEY, JACQUELINE N (contact)

PROJECT_TERMS: 15q;16p11.2;Address;Angelman Syndrome;Applications Grants;autism spectrum disorder;Behavior;behavior test;Behavior Therapy;Behavioral;Behavioral Assay;behavioral outcome;behavioral phenotyping;Biological Assay;Biological Models;Breeding;California;career;Clinical;cohort;Collaborations;Communities;Consultations;Country;Data Analyses;design;Development;Diagnosis;Disability research;Doctor of Philosophy;Down's Syndrome;Experimental Designs;experimental study;Face;Faculty;Family;Female;Foundations;Fragile X Syndrome;Funding;Genetic;Genotype;Goals;Human;Human Resources;Immune system;Immunologics;improved;innovation;insight;Intellectual and Developmental Disabilities Research Centers;Intellectual functioning disability;International;Leadership;Learning;Life Cycle Stages;male;Manuscripts;Mediating;Methods;Mission;Modeling;mouse model;Mus;neural;Neuroanatomy;neurobehavioral;Neurobiology;novel;Outcome Measure;Persons;Phelan-McDermid syndrome;pre-clinical research;Prevention;Procedures;Productivity;Protocols documentation;Publications;Quality of life;Rattus;Reproducibility;Research Design;Research Personnel;Research Project Grants;Research Support;Rett Syndrome;Risk Factors;Rodent;Rodent Model;Services;sex as a biological variable;Standardization;Supervision;Symptoms;System;Training;Translational Research;United States National Institutes of Health;Universities

PROJECT_TITLE: Core D. Rodent Behavior Core


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Immunization;Immunotherapy;Nanotechnology;Orphan Drug;Radiation Oncology;Rare Diseases;Vaccine Related

ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE The goal of this project is to define the mechanisms by which radioenhancing nanoscale metal-organic framework (nMOF) particles can be combined with immunostimulatory CpG to alter the immune microenvironment in order to facilitate checkpoint blockade immunotherapies in head and neck cancer. The proposed research is relevant to the NIH's mission because X-ray irradiation represents a significant treatment option for many cancer patients, and nMOFs possess a unique advantage by enabling the more effective radiotherapy-radiodynamic therapy at palliative X-ray doses. The proposed research is relevant to public health because this new therapeutic strategy can synergize with current checkpoint blockade immunotherapy to treat localized, recurrent, and metastatic cancers.

PI_NAMEs: LIN, WENBIN  (contact);WEICHSELBAUM, RALPH R

PROGRAM_OFFICER_NAME: CAPALA, JACEK

PROJECT_TERMS: Abscopal effect;adaptive immune response;Address;Affect;Aftercare;anti-cancer;Antibodies;Antigen Presentation;Antigen-Presenting Cells;Antigens;antitumor effect;Cancer Patient;Cancer Vaccines;CD4 Positive T Lymphocytes;CD8B1 gene;Cells;checkpoint therapy;Chemistry;chemotherapy;Clinical;clinically relevant;Combination immunotherapy;Coupled;CPG-oligonucleotide;Data;Dendritic cell activation;Disease;Disseminated Malignant Neoplasm;Dose;effective therapy;effector T cell;Extracellular Matrix;Fibroblasts;Genes;genetic signature;Goals;Hafnium;Head;Head and Neck Cancer;Head and Neck Squamous Cell Carcinoma;HPV positive;HPV-negative head and neck cancer;Hydroxyl Radical;Immune;immune activation;immune cell infiltrate;immune checkpoint blockade;Immune checkpoint inhibitor;immune stimulatory agent;Immune system;Immunologic Adjuvants;Immunologic Memory;Immunologics;Immunotherapy;improved;Infiltration;innate immune mechanisms;innovation;Interferon Type I;Interferon Type II;Interferons;Irradiated tumor;irradiation;Macrophage;Malignant Neoplasms;Malignant Squamous Cell Neoplasm;Mediating;Metals;Metastatic/Recurrent;Methods;micronucleus;Mission;Modeling;Molecular;Mouth Neoplasms;Mus;nanomedicine;nanoscale;neoplastic cell;novel;novel therapeutic intervention;novel therapeutics;palliative;particle;Pathway interactions;Patients;PD-1 blockade;PD-1/PD-L1;PD-L1 blockade;Porphyrins;Process;programmed cell death protein 1;Proliferating;Proteins;Public Health;Radiation;Radiation Dose Unit;Radiation therapy;Radiation-Sensitizing Agents;radioresistant;Recurrence;Research;Resistance;response;RNA;Roentgen Rays;Signal Transduction;Singlet Oxygen;Squamous cell carcinoma;Stimulator of Interferon Genes;Surface;synergism;systemic toxicity;T cell infiltration;T cell response;T-Cell Activation;T-Cell Proliferation;Testing;Toxic effect;Treatment outcome;tumor;tumor eradication;tumor microenvironment;tumor-immune system interactions;United States National Institutes of Health;x-ray irradiation

PROJECT_TITLE: Nanoscale Metal-Organic Frameworks Enable Radiotherapy-Radiodynamic Therapy and Deliver CpG Oligodeoxynucleotides to Generate Tumor Vaccines and Potentiate Immunotherapy of Head and Neck Cancers


NIH_SPENDING_CATS: Brain Disorders;Down Syndrome;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric

PI_NAMEs: KIM, KYOUNGMI  (contact)

PROJECT_TERMS: Address;Advanced Development;Affect;analytical method;Animal Model;Attention deficit hyperactivity disorder;autism spectrum disorder;Behavior;Behavioral Sciences;Bioinformatics;Biology;Biometry;Body System;California;Cells;Clinical;Clinical Research;Clinical Trials;Cognition;complex data;Data;Databases;design;Development;Developmental Delay Disorders;DiGeorge Syndrome;Discipline;Discipline of obstetrics;Doctor of Philosophy;Down's Syndrome;Education;Ensure;Epidemiology;expectation;Faculty;Fragile X Syndrome;Funding;Future;Genetic;Genotype;Goals;high dimensionality;Immunology;improved;In Vitro;Incidence;Integrative Therapy;Intellectual and Developmental Disabilities Research Centers;interest;Knowledge;meetings;Mentors;Molecular Biology;Morbidity - disease rate;Neurology;Neurosciences;Outcome;Pediatrics;Phenotype;population based;pre-clinical;Process;Psychiatry;Publications;Reproducibility;Research;Research Design;Research Personnel;senior faculty;skills;social skills;Statistical Data Interpretation;Students;Syndrome;System;tool;Training;Translational Research;Universities;Work

PROJECT_TITLE: Core E. Biostatistics, Bioinformatics, and Research Design Core