NIH_SPENDING_CATS: Behavioral and Social Science;Breast Cancer;Cancer;Clinical Research;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Women's Health Research

PHR: Project Narrative While evidence of long-term clinical outcomes and quality-of-life data for cancer patients is trivial for treatment planning, manual extraction of data is an extremely challenging task for human curators and needs hours of manual chart-review. We propose to develop an open-source NLP toolkit for curating treatment administered (chemotherapy, immunotherapy, radiation, surgery) and clinical outcome (progression, recurrence) data longitudinally by parsing varying types of clinical narratives for performing population-wide cancer research. In this study, we will collaborate with two state-wide cancer registries (Georgia and California) for evaluating our NLP developments for cancer data curation and obtain a robust performance evaluation across heterogeneous populations.

PI_NAMEs: BANERJEE, IMON  (contact);KEEGAN, THERESA H M;RUBIN, DANIEL L

PROGRAM_OFFICER_NAME: MARIOTTO, ANGELA B

PROJECT_TERMS: Adherence;Adopted;Age;anti-cancer research;Anxiety;artificial intelligence algorithm;Biological;biological systems;Black Populations;Breast;Breast Cancer Patient;Breast Cancer Risk Factor;breast cancer survival;Breast Cancer Treatment;California;Cancer Burden;cancer classification;Cancer Patient;cancer prevention;cancer recurrence;cancer site;cancer survival;cancer therapy;Cessation of life;chemotherapy;Clinic;Clinical;clinical center;clinical encounter;Collaborations;Communication;comorbidity;computer scientist;Computerized Medical Record;cost;Data;Data Collection;data curation;data integration;Databases;Detection;Development;Diagnosis;Diagnostic Neoplasm Staging;Disease;Disparity;Distant Metastasis;Early Diagnosis;Epidemiologist;Ethnic Origin;Evaluation;experience;Fatigue;flexibility;follow-up;Funding;Future;Guidelines;Health system;Healthcare;Hispanic Populations;Hispanic Women;hormone therapy;Hospitals;Hour;Human;Immunotherapy;Informatics;informatics tool;Institution;Insurance Coverage;Intervention;Lead;Learning;low income country;Malignant Breast Neoplasm;Malignant neoplasm of prostate;Malignant Neoplasms;Manuals;Medical center;Mental Depression;Methodology;Methods;Mission;Modeling;molecular subtypes;Morbidity - disease rate;multidisciplinary;multimodal data;Natural Language Processing;Nausea;Neoplasm Metastasis;neoplasm registry;Not Hispanic or Latino;Oncologist;open source;Operative Surgical Procedures;Outcome;outcome prediction;Paper;Pathology;Pathology Report;patient population;Patient-Focused Outcomes;Patients;Pattern;Performance;physical conditioning;Population;population based;Population Heterogeneity;Primary Neoplasm;Process;Prognosis;Psyche structure;Quality of life;Race;Radiation;radiologist;Radiology Specialty;Recording of previous events;Recurrence;Registries;relational database;Reporting;Research Personnel;Role;Running;Site;socioeconomic disparity;Software Tools;Stage at Diagnosis;Structure;surveillance data;survival disparity;Team Nursing;Technology;Testing;Text;Time;tool;treatment and outcome;treatment planning;trend;Tumor stage;Tumor Subtype;University Hospitals;Validation;Visit

PROJECT_TITLE: Flexible NLP toolkit for automatic curation of outcomes for breast cancer patients


ADMINISTERING_IC: DK

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Diabetes;Mental Health;Pediatric;Prevention

ORG_CITY: BOSTON

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: JOSLIN DIABETES CENTER

ORG_STATE: MA

PHR: PROJECT NARRATIVE Adolescents and young adults with T1D, as a subgroup of the population with T1D, have the poorest glycemic control of all, reaching a peak mean A1c >9% around age 19; they, too, often experience diabetes distress. Diabetes distress is common in persons with type 1 diabetes (T1D) and contributes to suboptimal self-care behaviors and outcomes, especially for the high risk group of adolescents and young adults with T1D. In the proposed 2-year randomized clinical trial, we will implement and assess the impact of a behavioral/psycho- educational intervention to reduce diabetes distress, increase acceptance of self-care behaviors (with or without diabetes technologies), and improve glycemic outcomes in adolescents and young adults, aged 14-25 years, with T1D in order to optimize their short-term and long-term health.

PI_NAMEs: HOOD, KOREY K;LAFFEL, LORI M (contact)

PROGRAM_OFFICER_NAME: THORNTON, PAMELA L

PROJECT_TERMS: active method;Adolescent;Adolescent and Young Adult;Age;age group;aged;American;Anger;Area;Attitude;Behavior;Behavioral;Boston;care burden;care delivery;Caring;Childhood;Clinic;Clinical;clinically significant;Collaborations;college;Complex;Continuous Glucose Monitor;Control Groups;COVID-19 pandemic;Data;Dedications;depression prevention;depressive symptoms;Development;Devices;diabetes control;diabetes distress;diabetes education;diabetes management;Diabetes Mellitus;diabetes self-management;Distress;Ensure;evidence base;experience;Frustration;Funding;Glucose;glycemic control;Glycosylated hemoglobin A;group intervention;Health;high risk;high risk population;improved;improved outcome;Individual;Insulin-Dependent Diabetes Mellitus;International;Intervention;intervention participants;Left;life span;Link;Measures;Medical;medical appointment;Mental Health;Meta-Analysis;Monitor;Moods;National Institute of Diabetes and Digestive and Kidney Diseases;Nature;Occupational;Outcome;Parents;Participant;Patient Outcomes Assessments;Perception;Persons;poor health outcome;Population;post intervention;primary endpoint;primary outcome;programs;psychoeducational intervention;psychosocial;psychosocial outcome;Randomized;randomized, clinical trials;Recommendation;recruit;remote visit;Research;Research Personnel;Risk;routine screening;Sampling;San Francisco;Schedule;Schools;secondary endpoint;secondary outcome;Self Care;skill acquisition;Societies;Subgroup;Surveys;Symptoms;Technology;Testing;Time;treatment as usual;uptake;usual care arm;virtual;Visit;young adult

PROJECT_TITLE: Improving Glycemia & Reducing Diabetes Distress in Adolescents & Young Adults with T1D

STUDY_SECTION: BMHO

STUDY_SECTION_NAME: Biobehavioral Medicine and Health Outcomes Study Section[BMHO]


ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

ORG_STATE: PA

PI_NAMEs: WOLFE, JOHN H (contact)

PROGRAM_OFFICER_NAME: EGGERMAN, THOMAS L

PROJECT_TERMS: 3-Dimensional;adeno-associated viral vector;adenovirus mediated delivery;Alpha-mannosidase;alpha-Mannosidosis;Animal Model;Animals;Astrocytes;Axonal Transport;Blood;Blood - brain barrier anatomy;Blood Vessels;blood-brain barrier crossing;Body Weight;Brain;brain cell;Brain Diseases;brain parenchyma;brain pathway;Carotid Arteries;cell type;Cells;cellular transduction;Central Nervous System;Cerebrovascular system;Clinical;Clinical Trials;Complementary DNA;Data;Defect;delivery vehicle;design;Disease;Dose;effective therapy;Enzymes;experimental study;expression vector;Felis catus;Gene Delivery;gene therapy;Gene Transfer;Genes;Genome;Grant;Human;human disease;human model;Immune response;immunosuppressed;improved;Inherited;Injections;Intracarotid;intravenous injection;Label;Lesion;Lysosomal Storage Diseases;Mammals;Mannosidase;Mediating;Metabolic;Methods;Modeling;Modification;Monkeys;Mus;Mutation;Neurons;novel;Oligodendroglia;particle;Pathology;Pathway interactions;Patients;Production;promoter;receptor binding;receptor recycling;Regimen;Rodent;Route;Safety;scale up;Serotyping;Spinal Cord;Therapeutic;therapeutic enzyme;Time;Translations;uptake;vascular bed;vector;Viral;Viral Vector;Virion;Virus;Visualization;Weight

PROJECT_TITLE: Gene Transfer and NMR Studies in Alpha-Mannosidosis Brain

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


ADMINISTERING_IC: DC

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Neurosciences

ORG_CITY: COLLEGE PARK

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

ORG_STATE: MD

PHR: PROJECT NARRATIVE The rationale for the proposed research is that understanding the longitudinally-linked neural stages, representations, and mechanisms that underlie continuous speech processing, and ultimately permit speech understanding, will result in individually tuned innovative methods to assess and treat auditory disorders. Moreover, the neural components investigated in this proposal, separately and collectively, show great potential as objective measures of speech intelligibility; these measures provide a path for the development of brain-aware hearing aids and automated tuning of hearing assistive devices.

PI_NAMEs: SIMON, JONATHAN Z. (contact)

PROGRAM_OFFICER_NAME: MILLER, ROGER

PROJECT_TERMS: Acoustics;Area;attentional modulation;Auditory;Auditory area;auditory pathway;auditory processing;Auditory system;Awareness;Behavior;Brain;Brain Stem;Compensation;Development;Electroencephalography;Failure;Feedback;Frequencies;Goals;Hearing Aids;Hearing problem;Individual;innovation;Knowledge;Language;lexical;Linguistics;Link;Magnetoencephalography;Measures;Methods;Midbrain structure;Modeling;neural;normal hearing;Patient Self-Report;Periodicity;Physiological;Prefrontal Cortex;Process;programs;Proxy;Research;Resolution;response;Role;Semantics;Series;Signal Transduction;Specific qualifier value;Speech;Speech Intelligibility;speech processing;Stimulus;temporal measurement;Testing;Thalamic structure;Time

PROJECT_TITLE: Multilevel Auditory Processing of Continuous Speech, from Acoustics to Language

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


ADMINISTERING_IC: EY

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision

ORG_CITY: TAMPA

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF SOUTH FLORIDA

ORG_STATE: FL

PHR: Public Health Relevance The knowledge gap in our understanding of ocular surface immunomodulation is a barrier for developing relevant new therapies for corneal inflammatory disorders and fibrosis that account for the most common reasons for outpatient visits to an ophthalmologist. By elucidating exciting new information related to the ocular surface immunomodulatory functions of SLURP1- an abundantly expressed yet understudied molecule- this project will lay a solid foundation for development of new therapies targeting ocular surface inflammation.

PI_NAMEs: SWAMYNATHAN, SHIVALINGAPPA KOTTUR (contact)

PROGRAM_OFFICER_NAME: MCKIE, GEORGE ANN

PROJECT_TERMS: Address;Anti-Inflammatory Agents;Behavior;Cauterize;Chemotaxis;Cornea;corneal epithelium;Corneal Neovascularization;cytokine;Development;Diagnostic;Disease;Dry Eye Syndromes;Endothelial Cells;Endothelium;Epithelial Cell Junction;experimental study;Extravasation;Feedback;Fibrosis;Foundations;Healthcare Systems;Homeostasis;Human;Immune;immunoregulation;In Vitro;Infiltration;Inflammation;Inflammatory;Injury;Intercellular Junctions;Knock-out;Knockout Mice;Knowledge;Laboratories;Liquid substance;Mediating;member;migration;Mission;monolayer;mouse model;Nature;neovascularization;neutrophil;Neutrophil Infiltration;new therapeutic target;novel therapeutics;ocular surface;ocular surface disease;Ophthalmologist;Organism;Outcome;Outpatients;Pathway interactions;Patients;PI3K/AKT;Plasma;Plasminogen Activator;Production;Protein Family;Proteins;public health relevance;Publications;Reporting;Role;Severities;Signal Transduction;Silver Nitrate;Solid;Testing;therapeutic target;TNF gene;transcriptome;transcriptome sequencing;Transforming Growth Factor beta;Tube;Umbilical vein;United States National Institutes of Health;Urokinase;Vascular Endothelial Cell;Visit

PROJECT_TITLE: Ocular surface functions of SLURP1


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: BALTIMORE

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Current immunotherapy treatments have shown minimal therapeutic activity in pancreatic adenocarcinomas (PDA). This is due to the lack of effective T cell generation and the still unknown complex signals in the PDA tumor microenvironment (TME) that prohibit T cell infiltration and function. With the expertise of our multidisciplinary team of researchers, our Program will identify optimal combination therapies for inducing quality T cells and bypassing TME suppressive signals to yield effective antitumor immunity against PDAs.

PI_NAMEs: JAFFEE, ELIZABETH M. (contact)

PROGRAM_OFFICER_NAME: HENDERSON, LORI A

PROJECT_TERMS: Acceleration;Achievement;Address;angiogenesis;Animal Model;Animals;anti-CTLA4;anti-PD-1;Antigens;arm;Bioinformatics;Biological Assay;Biological Markers;Biometry;Bypass;Cell Physiology;cell type;Cells;chemotherapy;Chemotherapy-Oncologic Procedure;Chronic;Clinical;Clinical Data;Clinical Research;Clinical Trials;combinatorial;Combined Modality Therapy;Complex;Data;data integration;Databases;Dendritic Cells;design;digital pathology;DNA analysis;effector T cell;Environment;Epigenetic Process;Exclusion;Feeds;Fibroblasts;Future;Generations;Genetic;genomic data;Genomics;Granulocyte-Macrophage Colony-Stimulating Factor;Histone Deacetylase Inhibitor;Human;Immune;Immune checkpoint inhibitor;Immune response;Immune System Diseases;Immunotherapy;improved;Incidence;Infiltration;Inflammation;Inflammatory;innovation;Interleukin-8;KRAS2 gene;Learning;Malignant neoplasm of pancreas;Malignant Neoplasms;monocyte;mouse model;multidisciplinary;Mus;Mutate;Mutation;Myelogenous;Myeloid Cells;Myeloid-derived suppressor cells;neoantigen vaccine;neoantigens;novel;novel vaccines;Oncogene Activation;Outcome;Pancreas;Pancreatic Adenocarcinoma;Pancreatic Ductal Adenocarcinoma;pancreatic stellate cell;patient stratification;Patients;peripheral blood;Population;pre-clinical;preclinical study;Procedures;programs;Proteomics;Reaction;recruit;Regulation;Regulatory T-Lymphocyte;Reporting;Research Design;Research Personnel;Resistance;RNA analysis;Science;Signal Transduction;Source;standard of care;Standardization;Stromal Cells;Survival Rate;T cell infiltration;T cell response;T cell therapy;T-Lymphocyte;Technology;Testing;The Cancer Genome Atlas;Therapeutic;Therapeutic Intervention;trafficking;translational clinical trial;treatment response;tumor;Tumor Immunity;tumor microenvironment;Tumor-associated macrophages;Undifferentiated;Vaccines

PROJECT_TITLE: Transforming Human Pancreatic Cancer Into An Immunologic Disease


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Digestive Diseases;Genetics;Human Genome;Immunization;Immunotherapy;Orphan Drug;Pancreatic Cancer;Rare Diseases;Vaccine Related

PHR: Project 1 Narrative (3 sentences) This project will evaluate vaccines against tumor-specific antigens with immune checkpoint inhibitors (ICIs) in pancreatic cancer patients. We will test the hypothesis that these vaccines given with agents that reprogram the tumor microenvironment, will convert an immunologically insensitive tumor into one that responds to ICIs.

PROJECT_TERMS: Adjuvant;Affect;Algorithms;Amino Acids;analytical tool;Antigen Targeting;antigen-specific T cells;Antitumor Response;B-Lymphocytes;Back;Binding;Cancer Burden;cancer immunotherapy;cancer infiltrating T cells;Cancer Patient;Categories;CD8-Positive T-Lymphocytes;Cell Count;Cell Death;Cells;checkpoint therapy;Chronic Disease;Clinical;Clinical Trials;Collaborations;Combination immunotherapy;combinatorial;CTLA4 gene;cytokine;Cytometry;Data;effector T cell;Epitopes;Exclusion;exhaustion;exome sequencing;FDA approved;Flow Cytometry;Future;Gene Expression;Genetically Engineered Mouse;Glioblastoma;Human;Immune;immune activation;Immune checkpoint inhibitor;immune modulating agents;Immune response;Immune System Diseases;immunocytochemistry;immunogenicity;Immunologics;immunoregulation;improved;Infiltration;inhibiting antibody;ipilimumab;KPC model;KRAS2 gene;Lesion;Ligands;MADH4 gene;Malignant neoplasm of pancreas;Malignant Neoplasms;Melanoma;Memory;Metastatic Pancreatic Adenocarcinoma;MHC Class I Genes;MHC Class II Genes;Modeling;monocyte;mouse model;Mus;mutant;Mutate;Mutation;neoantigen vaccine;neoantigens;neoplastic cell;Nivolumab;nonsynonymous mutation;Normal Cell;novel;novel strategies;Oncoproteins;Outcome;Pancreatic Adenocarcinoma;pancreatic cancer patients;Pathway interactions;Patients;Peptide Vaccines;Peptides;peripheral blood;Point Mutation;pre-clinical;premalignant;prevent;Prevention;programmed cell death ligand 1;programs;Proteins;Publishing;Reporting;Resected;Resistance;response;Signal Transduction;single-cell RNA sequencing;Somatic Mutation;Stromal Cells;synergism;T cell infiltration;T cell receptor repertoire sequencing;T cell response;T memory cell;T-Cell Depletion;T-Lymphocyte;targeted agent;targeted treatment;Technology;Testing;TP53 gene;transcriptome sequencing;tumor;Tumor Antigens;Tumor Burden;Tumor Immunity;tumor microenvironment;Tumor Tissue;Tumor-associated macrophages;tumor-immune system interactions;tumorigenesis;vaccine evaluation;Vaccines;Work

PROJECT_TITLE: Integration of neo-antigen vaccines and immune checkpoint therapy


ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: Gestational diabetes is a major global health problem. As the incidence of this disease is dramatically increasing worldwide, understanding the pathogenesis of this disease is needed. Because of this, here, we explore, through the variety of cell lines, mouse models, and human tissues, the role of one of the major genetic links to gestational diabetes, HKDC1.

PI_NAMEs: LAYDEN, BRIAN THOMAS (contact);REDDY, TIMOTHY E

PROGRAM_OFFICER_NAME: LIANG, HANYU

PROJECT_TERMS: adverse pregnancy outcome;Automobile Driving;Biological Assay;blood glucose regulation;Carbon;causal variant;Cell Line;cell type;Closure by clamp;Data;diabetes risk;Disease;Energy Metabolism;epigenome editing;Equilibrium;euglycemia;Future;Genes;Genetic;genetic association;Genetic study;genetic variant;genome editing;Genomics;Gestational Diabetes;global health;Glucose;glucose metabolism;glucose production;glucose tolerance;Glucose tolerance test;Goals;Grant;Haplotypes;Hepatic;Hepatocyte;hexokinase;Homeostasis;Human;human tissue;Hyperglycemia;Hyperinsulinism;improved;in vivo;Incidence;innovation;Insulin Resistance;Investigation;ketogenesis;Ketones;Knockout Mice;Label;Lead;Length;Life;Link;Lipids;Liver;maternal outcome;Mediating;Membrane Proteins;Metabolic;Metabolism;metabolomics;Mitochondria;Modeling;Molecular;Morphology;mouse model;Mus;N-terminal;Newborn Infant;novel;Nutrient;nutrient metabolism;Outcome;Outcome Study;Outer Mitochondrial Membrane;overexpression;Pathogenesis;Pathway interactions;Plasma;Play;Pregnancy;Regulation;Regulatory Element;Role;Testing;Therapeutic;Tissues;Translating;Untranslated RNA;Variant;Viral;Woman

PROJECT_TITLE: The function and regulation of the novel pregnancy-specific hexokinase HKDC1

STUDY_SECTION: INMP

STUDY_SECTION_NAME: Integrative Nutrition and Metabolic Processes Study Section[INMP]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: NEW YORK

ORG_DEPT: UROLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: OVERALL: NARRATIVE Lower urinary tract symptoms (LUTS) and urinary tract infections (UTI) are very common disorders in the general population. The multidisciplinary Research Projects of the Columbia University George M. O’Brien Urology Cooperative Research Center build upon the work conducted in the prior cycle to address questions related to the genetic, cellular, and metabolic events that lead to lower urinary tract disorders such as LUTS and UTI, and devise new methods for prevention and treatment, while providing educational enrichment for future scientists and promoting collaborations with investigators within urology and other fields

PI_NAMEs: BARASCH, JONATHAN M.;GHARAVI, ALI G;MENDELSOHN, CATHY LEE (contact)

PROGRAM_OFFICER_NAME: NIHALANI, DEEPAK

PROJECT_TERMS: Address;Agonist;Anatomy;Animal Model;Award;Bacteria;Bacterial Genes;base;Benign;biobank;Biological;Biology;Bladder;career;cell type;Cells;Cellular biology;Chelating Agents;Cities;Clinical;cohort;Collaborations;college;Communities;comparative genomics;Consultations;Data;data sharing;database of Genotypes and Phenotypes;Dedications;Defect;Defense Mechanisms;Deposition;Development;disability;Disease;Drug Metabolic Detoxication;Drug resistance;drug resistant microorganism;Education;Electronic Medical Records and Genomics Network;Encapsulated;Epithelium;Event;Evolution;exome sequencing;experience;experimental study;Faculty;Functional disorder;Funding;Future;gain of function;Gases;gene discovery;General Population;Generations;Genes;Genetic;genetic disorder diagnosis;Genetic study;Genitourinary system;genome wide association study;genomic data;Health;Heme;Homeostasis;Human;human model;Immune;Infection;Inflammatory Response;innovation;Interdisciplinary Study;Iron;Knowledge;large datasets;LCN2 gene;Lower urinary tract;lower urinary tract symptoms;Maryland;Medical;Medicine;Mentored Clinical Scientist Development Program;Metabolic;Metabolic Pathway;Metabolism;Metagenomics;Methods;Microbial Genetics;microbial genomics;Microbiology;microbiome;microbiome analysis;Mind;Minority;Missouri;Molecular;mouse model;Mus;Mutagenesis;Mutant Strains Mice;National Institute of Diabetes and Digestive and Kidney Diseases;Nephrology;New York City;next generation;novel;Nuclear Receptors;Nutritional Immunity;Organ;outreach;Pathology;Pathway interactions;Patients;personalized genomics;Pharmaceutical Preparations;Phenotype;Plasmids;PPAR gamma;PPARG gene;Prevention;Productivity;professor;programs;Proteins;Publications;Publishing;Reagent;Reflux;repaired;Reporter;Research;Research Design;Research Personnel;Research Project Grants;Resources;response;response to injury;risk variant;RNA;Role;Science;Scientist;Series;Services;Signal Pathway;Students;success;summer research;symposium;Symptoms;Therapeutic;tool;Training;transcriptome sequencing;Universities;urinary;Urinary Microbiome;Urinary tract;Urinary tract infection;urologic;Urologic Diseases;Urologist;Urology;Urothelium;Virulence;Wisconsin;Work;XCL1 gene

PROJECT_TITLE: Investigating the Genetic, Cellular, and Metabolic Events Important for Urothelial Homeostasis and Response to Injury


ADMINISTERING_IC: NS

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: PROJECT NARRATIVE The brain’s capacity to use contextual information to modulate behavior is essential to maintain human health and quality of life. This proposal will use a multidisciplinary approach to elucidate molecular and cellular principles that enable neurons to translate contextual information into behaviors. Results of this study will elucidate novel pathways for context-dependent behavior and improve our understanding of the brain power in translating contextual information into behaviors.

PI_NAMEs: ROSERO, MANUEL  (contact)

PROGRAM_OFFICER_NAME: KIM, JENNY LILY

PROJECT_TERMS: Animals;Behavior;Biological Assay;Brain;Caenorhabditis elegans;Candidate Disease Gene;Collection;Color;contextual factors;Coupling;Cyclic GMP;cyclic-nucleotide gated ion channels;design;Environment;Enzymes;Esthesia;experience;Experimental Designs;experimental study;Failure;Genes;Genetic;Goals;Guanylate Cyclase;Health;Human;Illusions;Image;improved;in vivo;Individual;interdisciplinary approach;Invertebrates;Locomotion;Mental disorders;Metabolic Control;Metabolism;Molecular;movie;Nematoda;Nervous System;Nervous System Disorder;neural circuit;neuronal circuitry;Neurons;novel;Optical Illusions;Pathway interactions;Perception;phosphoric diester hydrolase;physical property;Quality of life;Regulation;response;Role;Signal Pathway;Signal Transduction;Signaling Molecule;social;Taxes;Translating;Work

PROJECT_TITLE: In vivo mechanisms for integration of contextual information


PI_NAMEs: MENDELSOHN, CATHY LEE (contact)

PROJECT_TERMS: Administrator;Agonist;Award;Bacteria;Benign;Biology;Biomedical Research;Blood-Borne Pathogens;cell type;Cells;Certification;Chad;Chelating Agents;Chemistry;Clinical Research;Collaborations;Communication;Communities;Development Plans;Disease;Education;Education and Outreach;Ensure;Event;experience;Functional disorder;Funding;Future;Genetic;genetic testing;genetic variant;Genitourinary system;Genome;genome wide association study;Goals;Heme;Heme Iron;Homeostasis;IACUC;Immune;Incontinence;Individual;Infection;insight;Invaded;Iron;iron metabolism;Leadership;Lower urinary tract;Malignant Neoplasms;Maryland;Medical Students;member;Metabolic;microbial genomics;Microbiology;microbiome;Mission;Monitor;Mus;Mutation;National Institute of Diabetes and Digestive and Kidney Diseases;Nutrient;Obstruction;Outcome;outreach;Pathogenesis;Pathway interactions;Patients;Pelvic floor structure;Pre-Clinical Model;preclinical study;programs;Prostate;Ptosis;recruit;Regulation;repaired;Reporting;Research;Research Activity;Research Personnel;Research Project Grants;response;response to injury;responsible research conduct;Role;Scientist;Shapes;Siderophores;Stream;Student recruitment;Students;summer program;summer student;Supervision;symposium;Therapeutic;tool;Training;Training and Education;Training Programs;Transcriptional Regulation;undergraduate student;Underrepresented Students;United States National Institutes of Health;Universities;Urethra;urinary;Urinary Microbiome;Urine;Urogenital Diseases;urogenital tract;urologic;Urology;Urothelial Cell;Urothelium;web site;Wisconsin;Work

PROJECT_TITLE: Administrative Core


ADMINISTERING_IC: ES

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

ORG_CITY: DETROIT

ORG_DEPT: MISCELLANEOUS

ORG_NAME: WAYNE STATE UNIVERSITY

ORG_STATE: MI

PHR: Exposure to the class of environmental toxicants known as per- and polyfluoroalkyl substances (PFAS) has been associated with increased risk factors for cardiometabolic disease, including hypercholesterolemia. The proposed research will investigate if PFAS exposure can therefore induce the development of atherosclerosis, while also seeking to understand mechanisms causing the atherosclerosis that are related to bile acid metabolism and transport.

PI_NAMEs: ROTH, KATHERINE  (contact)

PROGRAM_OFFICER_NAME: SCHUG, THADDEUS

PROJECT_TERMS: absorption;Acceleration;Acids;Animals;Aorta;ASBT protein;Atherogenic Diet;Atherosclerosis;atherosclerosis risk;bile acid metabolism;bile acid transporter;Bile Acids;bioaccumulation;Biology;Blood;Cardiometabolic Disease;cardiometabolism;Cardiovascular Models;career;Carpet;Chemicals;Cholesterol;cholesterol absorption;Clinical;Clothing;consumer product;Cross-Sectional Studies;Data;Development;Diet;Diet Research;Dietary Cholesterol;dietary manipulation;disease model;drinking water;effective intervention;Environment;epidemiology study;Excretory function;experimental study;Exposure to;Female;Gene Modified;High Density Lipoproteins;Human;hypercholesterolemia;Industrial Product;Inflammatory;Laboratories;LDL Cholesterol Lipoproteins;Lead;Length;Lesion;Link;Lipids;lipoprotein cholesterol;Low Density Lipoprotein Receptor;Low-Density Lipoproteins;Macrophage;magnetic beads;male;man;Mediating;Medicine;member;Modeling;Monitor;mouse model;Mus;Myocardial Infarction;Oils;Outcome;Pathologic;Pattern;Pharmacologic Substance;Phenotype;pollutant;Poly-fluoroalkyl substances;Population;post-doctoral training;Postdoctoral Fellow;Process;Property;Proteins;Publishing;Reporting;Research;research faculty;Resistance;reuptake;Risk Factors;Rodent;skills;Sterols;Stroke;surfactant;Testing;Toxic effect;Toxic Environmental Substances;Training;transcriptomic profiling;unpublished works;Very low density lipoprotein;Wild Type Mouse;Work

PROJECT_TITLE: Exposure to PFAS mixture induces atherosclerosis via modulation of bile acid transport


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: The burden of chronic disease disparities is most evident among African American and Hispanic/Latino populations in the southeastern United States. To address these pervasive health inequities, the Southeast Collaborative for Innovative and Equitable Solutions to Chronic Disease Disparities we will bring together expertise at Vanderbilt University Medical Center, University of Miami School of Medicine, and Meharry Medical College to collaboratively develop and implement multi-level interventions. The Center will partner with communities and will leverage advances in technology and data science to reduce risk factors for and disparities in diabetes, cardiovascular disease, obesity, and related conditions among African American and Latino populations.

PI_NAMEs: COX, NANCY J;MILLER-HUGHES, STEPHANIA T.;WEISS, ROY E;WILKINS, CONSUELO HOPKINS (contact)

PROGRAM_OFFICER_NAME: STINSON, NATHANIEL

PROJECT_TERMS: Academic Medical Centers;adaptive intervention;Address;African American;African American population;Asthma;Award;Behavior;Behavioral;Bioinformatics;Biological;Black Populations;Black race;burden of chronic illness;Cardiovascular Diseases;career development;Cause of Death;Cessation of life;Chronic;Chronic Disease;Clinical;Collaborations;Communities;community engaged intervention;Community Health Aides;Complex;coping mechanism;culturally appropriate intervention;Data;data harmonization;Data Science;Decision Making;Dentists;design;diabetes management;Diabetes Mellitus;Disadvantaged minority;Discipline;Discrimination;disease disparity;Disparity;Doctor of Philosophy;Environment;Equity;ethnic health disparity;ethnic minority;experience;Faculty;family support;Fostering;Genetic;genomic data;Glycosylated hemoglobin A;Health;health data;Health Disparities Research;health disparity;health equity;Health Expenditures;health inequalities;Health Insurance;Health Professional;Health Services Accessibility;Health system;Hispanic;Home;Human;Hypertension;implementation science;improved;Individual;Infrastructure;innovation;Institution;International;Intervention;Latino;Latino Population;Lead;Link;Lived experience;Malignant Neoplasms;medical schools;Medicine;Mentors;mHealth;Minority;novel;Obesity;Operative Surgical Procedures;Outcome;Patients;Personal Satisfaction;personalized medicine;phenotypic data;Physicians;Policies;Population;population health;Poverty;premature;prevent;preventable death;Prevention;professional atmosphere;professor;programs;Psyche structure;Quality of life;racial health disparity;racial minority;racism;Research;Research Personnel;Resources;Risk;Risk Factors;Risk Reduction;Rural Community;Science;Scientist;Secure;Services;skills;Sleep;social;social health determinants;Social support;Social Work;Socioeconomic Status;Southeastern United States;Stephania;Structural Racism;Structure;Technology;Testing;Time;Tobacco use;Training;Trauma;United States Public Health Service;Universities;Urban Community;Vascular Diseases


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Digestive Diseases;Immunization;Immunotherapy;Pancreatic Cancer;Rare Diseases;Vaccine Related

PHR: Project Narrative We have previously shown that histone deacetylase (HDAC) inhibitors can have significant effects on pancreatic cancer cells as well as the immune cells that are within pancreatic cancers. The overall goal of our project is to understand the mechanisms through which this epigenetic therapy affects the immune system's interaction with pancreatic cancer, and to investigate the potential for synergy between epigenetic therapies and other treatments that work on the immune system, to improve outcomes for patients with pancreatic cancer. We will accomplish these goals using mouse models of pancreatic cancer as well as tissues from a human clinical trial combining HDAC inhibition and immunotherapy in pancreatic cancer.

PI_NAMEs: AZAD, NILOFER S. (contact)

PROJECT_TERMS: Affect;anti-PD-1;anti-PD1 therapy;antitumor effect;Biological Models;Biology;Biopsy;Biopsy Specimen;Cell Physiology;cell stroma;cell type;Cells;Chemoresistance;Clinical;Clinical Trials;Collaborations;Combination immunotherapy;Combined Modality Therapy;Cytometry;Data;Epigenetic Process;epigenetic silencing;epigenetic therapy;Exclusion;experience;Foundations;Funding;Future;Goals;Histone Deacetylase Inhibitor;Human;human model;Immune;Immune checkpoint inhibitor;Immune response;Immune system;Immune System Diseases;Immune Targeting;Immunohistochemistry;Immunologic Sensitization;Immunology procedure;immunoregulation;Immunotherapy;improved outcome;in vivo Model;Inflammatory;inflammatory modulation;inhibitor;inhibitor therapy;Investigation;Learning;Ligands;Malignant neoplasm of pancreas;Malignant Neoplasms;Mediating;Metastatic Pancreatic Adenocarcinoma;Molecular;mouse model;Mus;Mutation;Myelogenous;Myeloid-derived suppressor cells;Natural Selections;neoantigens;neoplastic cell;Nivolumab;novel;Pancreatic Adenocarcinoma;pancreatic cancer cells;pancreatic cancer model;pancreatic cancer patients;Pathway interactions;Patients;Population;pre-clinical;Pre-Clinical Model;Predisposition;Process;programmed cell death protein 1;programs;Regulation;Reporting;resistance mechanism;responders and non-responders;response;Role;Signal Pathway;Signal Transduction;single cell analysis;STAT3 gene;Stromal Cells;synergism;T cell infiltration;T-Cell Receptor;T-Lymphocyte;targeted agent;Testing;Therapeutic;Therapeutic Trials;Tissues;trafficking;Transcriptional Regulation;transcriptome sequencing;Translating;tumor;Tumor Immunity;tumor microenvironment;tumor-immune system interactions;Tumor-Infiltrating Lymphocytes;vaccine development;Vaccines;Work

PROJECT_TITLE: Mechanisms of immunomodulation with epigenetic therapy


ORG_DEPT: PHARMACOLOGY

PHR: PROJECT NARRATIVE CpH (H=A/C/T) methylation was found high level in neurons and plays important roles in brain development and neurological disorders. Using a state-of-the-art protein array, Digital Affinity Profiling via Proximity Ligation (DAPPL), a viral in vivo delivery system and high-throughput sequencing technologies, we will identify sequence-independent and -dependent mCpH-binding proteins and characterize their roles in transcriptional and chromatin regulation in adult mouse brain. These data will provide a foundation to investigate the roles of CpH methylation in brain disorders.

PI_NAMEs: SU, YIJING ;ZHU, HENG  (contact)

PROGRAM_OFFICER_NAME: LEE, CRYSTAL ANNE

PROJECT_TERMS: Adult;Affinity;Aliquot;Amyotrophic Lateral Sclerosis;ATAC-seq;Bar Codes;base;Behavioral;Binding;Binding Proteins;Biological Assay;Biological Process;bisulfite;Brain;Brain Diseases;candidate selection;candidate validation;carcinogenesis;Cells;ChIP-seq;Chromatin;conditional knockout;Cytoplasmic Granules;Cytosine;Data;deep sequencing;dentate gyrus;Development;Dideoxy Chain Termination DNA Sequencing;digital;Dinucleoside Phosphates;DNA;DNA Library;DNA Methylation;DNA Sequence;DNA Transposable Elements;DNMT3a;Effectiveness;Elements;embryonic stem cell;EMSA;Epigenetic Process;Foundations;Fragile X Syndrome;Funding;gain of function;Gel;Gene Expression;Gene Expression Regulation;gene repression;Genes;Genetic Transcription;Genome;Genomic Imprinting;Germ Lines;Goals;Guanine;high throughput screening;High-Throughput Nucleotide Sequencing;histone modification;Human;In Vitro;in vitro Assay;in vivo;Incubated;induced pluripotent stem cell;innovation;insight;Kinetics;Knockout Mice;Lead;Libraries;life span;Ligation;Literature;loss of function;Luciferases;Maintenance;mammalian genome;Mediating;Methyl-CpG-Binding Protein 2;Methylation;Methyltransferase;Modification;Molecular;motor impairment;mouse model;Mus;Mutation;Nervous System;Nervous System Disorder;Neurodevelopmental Disorder;Neurons;Neurophysiology - biologic function;new therapeutic target;Outcome;Phase;Phenotype;Play;Pluripotent Stem Cells;postmitotic;postnatal;Protein Array;Proteins;Reader;recruit;Regulation;Reporting;Resolution;Resources;Rett Syndrome;Role;Series;stem cells;success;synaptogenesis;System;Technology;Testing;Tissues;Transcription Alteration;transcription factor;Transcription Repressor;Transcriptional Regulation;transcriptome sequencing;Validation;Viral;X Inactivation

PROJECT_TITLE: Identification and characterization of mCpH binding proteins in neurons

STUDY_SECTION: NCF

STUDY_SECTION_NAME: Neurogenesis and Cell Fate Study Section[NCF]


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: LOS ANGELES

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: Project Narrative Asian immigrant women have a higher risk of an unintended birth compared to White women, and are less likely to report recent use of sexual and reproductive healthcare compared to US-born Asian women. Despite these trends, there is a lack of disaggregated data by ethnicities and immigration statuses, contributing to the invisibility of Asian women. This study will significantly contribute to our understanding of the mechanisms and protective factors that moderate immigration status and use of sexual and reproductive healthcare and to the identification of novel community, social, and policy-level interventions that can improve the sexual and reproductive health of Asian immigrant women.

PI_NAMEs: SUDHINARASET, MAY  (contact)

PROGRAM_OFFICER_NAME: POPKIN, RONNA

PROJECT_TERMS: Accounting;Address;Adolescence;Adult;Affect;Age;aged;Asian;Asian Pacific American;Asian population;Asian Women;Birth;California;Categories;Childhood;Chinese;Cities;Communities;community building;community organizations;Country;Data;Discrimination;economic determinant;Economics;ethnic disparity;Ethnic Origin;Exclusion;experience;Face;Family;Female;Filipino;Food;Fright;Goals;Health;health care availability;health data;health equity;health inequalities;Healthcare;Heterogeneity;high risk;Hispanic;Hispanic Populations;Immigrant;Immigration;Improve Access;improved;Individual;Inequity;interest;Intervention;Interview;Justice;Knowledge;Koreans;Latino Population;Legal;Life;Life Cycle Stages;life history;Los Angeles;Mediating;Mediator;Methods;Modeling;multidisciplinary;neglect;New York;New York City;novel;outreach;peer;Policies;Politics;Population;Population Heterogeneity;Positioning Attribute;programs;protective factors;psychosocial;racial disparity;Recording of previous events;recruit;Reporting;reproductive;Reproductive Health;Reproductive Health Services;Research;Resources;Respondent;Risk;Sampling;Services;sexual and reproductive health;social;social capital;social cohesion;social stigma;starfish sampling;statistics;Stress;Students;Surveys;Texas;Time;trend;unintended pregnancy;Unsafe Sex;Variant;Voice;White Women;Woman;Work

PROJECT_TITLE: Use of Reproductive Health Care among Asian Immigrant Women

STUDY_SECTION: HHD

STUDY_SECTION_NAME: Healthcare and Health Disparities Study Section[HHD]


ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: SANTA FE

ORG_NAME: NEW MEXICO STATE DEPARTMENT OF HEALTH

ORG_STATE: NM

PHR: Project Narrative  The New Mexico Department of Health Scientific Laboratory Division (NMDOH SLD) Environmental Microbiology laboratory intends to continue participation in the National Antimicrobial Resistance Monitoring System Retail Meat Surveillance project. The SLD EM laboratory will continue to support the goal of the project by determining the prevalence of antimicrobial resistance among Salmonella, Campylobacter, E. coli, Enterococcus species, Vibrio species, Aeromonas species and Lactose fermenters isolated from retail samples of retail chicken, ground turkey, ground beef, pork chops and seafood purchased from grocery stores in New Mexico. The laboratory will continue to provide testing for this project following established procedures and participate in any pilot studies that are introduced. Page 1 of 1

PI_NAMEs: ARAGON, ADAM  (contact)

PROGRAM_OFFICER_NAME: YOUNG, SHENIA

PROJECT_TITLE: NMDOH Scientific Laboratory Division Retail Meat Surveillance Program


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Cocaine;Drug Abuse (NIDA only);Neurosciences;Opioid Misuse and Addiction;Opioids;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: NEW YORK CITY

ORG_NAME: SPARIAN BIOSCIENCES, INC.

PHR: NARRATIVE Stimulant use disorder (StUD) is rapidly growing in the US with a current prevalence of ~3.2M and ~57K stimulant-related overdose deaths/year. However, there are no pharmacological treatments for StUD. We propose to develop a novel agent, SBS-518, a dual sigma receptor antagonist / DAT inhibitor for the treatment of stimulant use disorder to help curb this rising epidemic with a novel pharmacological therapy.

PI_NAMEs: REICH, JEFFREY  (contact)

PROGRAM_OFFICER_NAME: WHITE, DAVID A

PROJECT_TERMS: abuse liability;Active Biological Transport;Address;American;analog;antagonist;Attention;base;Behavior Disorders;Behavioral;Biological Availability;Books;Cessation of life;clinical candidate;clinical development;Clinical Trials;Cocaine;cocaine self-administration;Data;Death Records;Development;Dopamine;dopamine transporter;Dose;Drug Targeting;effective therapy;efficacy study;Epidemic;extracellular;Face;FDA approved;first-in-human;Foundations;Grant;holistic approach;Human;improved;inhibitor;innovation;Lead;lead candidate;lead optimization;Medical;medication-assisted treatment;Metabolic;Methamphetamine;Modality;mortality;National Institute of Drug Abuse;nonhuman primate;novel;novel therapeutics;Nucleus Accumbens;Opioid;opioid epidemic;opioid mortality;opioid use disorder;Oral;Overdose;overdose death;Persons;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;pharmacologic;Pharmacological Treatment;Pharmacotherapy;Phase;phase 1 study;Phase I Clinical Trials;pre-Investigational New Drug meeting;Prevalence;product development;Production;programs;prototype;psychosocial;psychostimulant;Public Health;Rattus;research and development;response;Rewards;Rodent;Safety;safety study;scale up;screening;Self Administration;sigma receptors;standard of care;Stimulant;stimulant use;stimulant use disorder;success;Synapses;Testing;Therapeutic Index;Toxicology;transport inhibitor;Work

PROJECT_TITLE: Development of sigma receptor/DAT dual-targeting compounds to treat stimulant use disorder

STUDY_SECTION: NIDA

STUDY_SECTION_NAME: Medication Development Research Study Section[NIDA-L]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biotechnology;Clinical Research;Emerging Infectious Diseases;Genetics;Infectious Diseases;Microbiome;Urologic Diseases

PI_NAMEs: UHLEMANN, ANNE-CATRIN  (contact)

PROJECT_TERMS: 16S ribosomal RNA sequencing;Adherence;Affect;Antimicrobial Resistance;Area;Bacteria;Bacterial Genes;Bacterial Infections;base;Benign;biobank;Bioinformatics;Biological;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;Collaborations;Communities;comparative;comparative genomics;Congenital Abnormality;Consultations;CRISPR/Cas technology;design;Disease;disease model;Drug resistance;Education;Ensure;Environment;Event;experience;Experimental Designs;experimental study;Future;Genes;Genetic;Genetic Polymorphism;Genome;genome sequencing;Genomic medicine;Genomics;Goals;Heme;Hi-C;Homeostasis;Human;human subject;improved;Individual;individual variation;Infection;Infection prevention;instrument;interest;Investigation;knockout gene;Laboratories;lectures;Life Style;Medical center;member;Mentorship;Metabolic;Metabolism;metagenome;Metagenomics;Methods;Microbe;Microbial Genetics;microbial genomics;microbiome;microbiome analysis;Mission;Modernization;Molecular Biology;mouse model;Multi-Drug Resistance;Mus;mutant;Mutation;National Institute of Diabetes and Digestive and Kidney Diseases;New York City;next generation;next generation sequencing;novel;Nucleic Acids;Organism;outreach;Participant;pathogen;Pathogenesis;Pathogenicity;Pathology;Pathway interactions;Patients;Pattern;Persons;Phenotype;Plasmids;Play;Policies;precision medicine;Preparation;programs;prospective;Public Health;Reproducibility;Research;Research Design;Research Personnel;Research Project Grants;Resource Sharing;Resources;response to injury;Ribosomal RNA;Role;sample collection;Sample Size;Sampling;Services;Site;Students;symptomatology;Symptoms;System;Technology;Testing;tool;Universities;urinary;Urinary tract infection;Urine;urologic;Urologic Diseases;Urology;Uropathogen;Urothelium;Vesico-Ureteral Reflux;whole genome

PROJECT_TITLE: Microbial Genomics Biomedical Core


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Immunization;Immunotherapy;Orphan Drug;Pancreatic Cancer;Precision Medicine;Prevention;Rare Diseases;Vaccine Related

PHR: Project Narrative Project 3 Our group has led several previous and ongoing studies of immunotherapy in pancreatic cancer which have shown promising activity, but the benefits appear limited to a small number of patients. This project seeks to understand the contribution of macrophages to suppression of the anti-tumor immune response and resistance to immunotherapy, and will test new treatment strategies incorporating macrophage-targeting agents into immunotherapy combinations. We will examine the impact of these agents on the composition of immune cells in the tumor and in the peripheral blood to better understand how they exert anti-tumor effects.

PI_NAMEs: LE, DUNG T (contact)

PROJECT_TERMS: Allogenic;anti-PD-1;anti-tumor immune response;antitumor effect;Antitumor Response;Biological Markers;Biopsy;booster vaccine;cancer type;Cells;checkpoint therapy;chemokine;chemotherapy;Clinical;clinical efficacy;Clinical Research;Clinical Trials;cohort;Combination immunotherapy;combinatorial;Combined Vaccines;CTLA4 gene;CXCR4 gene;Data;Dendritic Cells;design;Desmoplastic;experience;Granulocyte-Macrophage Colony-Stimulating Factor;GVAX Cancer Vaccine;Human;IL8RB gene;Immune;immune checkpoint;Immune checkpoint inhibitor;immune modulating agents;immune resistance;Immune response;Immune System Diseases;immunoregulation;Immunotherapeutic agent;Immunotherapy;immunotherapy clinical trials;Individual;Infiltration;inhibitor;Ligands;Listeria monocytogenes;Lymphoid;Macrophage;Malignant neoplasm of pancreas;mesothelin;Multi-Institutional Clinical Trial;Mus;Myelogenous;Myeloid Cells;Myeloid-derived suppressor cells;Neoadjuvant Study;Neoadjuvant Therapy;neoplastic cell;new combination therapies;novel;novel therapeutic intervention;Outcome;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma model;Pathway interactions;Patient Participation;patient subsets;Patients;peripheral blood;Phase;phase 2 study;Population;pre-clinical;precision oncology;preclinical study;prognostic;programmed cell death protein 1;Protocols documentation;Randomized;refractory cancer;Research Design;Resistance;response;Role;Series;Signal Transduction;Source;standard of care;Stromal Cells;synergism;T cell infiltration;T cell response;T-Cell Activation;T-Lymphocyte;targeted agent;Testing;Therapeutic Effect;Therapy trial;translational study;treatment response;trial design;Tryptophan 2,3 Dioxygenase;tumor;Tumor Antigens;Tumor Immunity;tumor microenvironment;Tumor-associated macrophages;Up-Regulation;vaccine evaluation;vaccine immunotherapy;vaccine strategy;Vaccine Therapy;Vaccines;Vertebral column;Whole Cell Vaccine;Work

PROJECT_TITLE: A precision oncology approach to integrating of tumor microenvironment suppressive cell modulators to enhance antitumor immunity


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Cost Effectiveness Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: NARRATIVE More people die of preventable disease in the United States than in other wealthy countries, especially among people with lower education or incomes. Previous research shows that 9 prevention goals could prevent most of these deaths. This proposal prepares to test whether free, convenient, and individualized training programs targeting these 9 goals could prevent deaths.

PI_NAMEs: BRAITHWAITE, RONALD SCOTT (contact)

PROGRAM_OFFICER_NAME: FREEMAN, ROBERT

PROJECT_TERMS: Age;alcohol use disorder;Algorithms;Appointment;Area;Australia;Behavioral;binge drinking;black men;brief intervention;Canada;cardiovascular disorder risk;cardiovascular risk factor;Cardiovascular system;Caring;Cessation of life;Characteristics;Chronic lung disease;Clinic;Communities;Compensation;cost;Cost Effectiveness Analysis;Country;Death Rate;Denmark;Depressive disorder;Diabetes Mellitus;Disease;Education;Elements;Ethnic Origin;European;Finland;Frequencies;Generalized Anxiety Disorder;Goals;Health;health disparity;health goals;Health system;Healthcare;Heavy Drinking;Hepatitis C virus;Hispanic Women;HIV;HIV risk;Hong Kong;Hour;Income;Individual;Injury;International;Intervention;Japan;Kidney Failure;Korea;Life Expectancy;Liver diseases;Liver Failure;low socioeconomic status;medication nonadherence;Mental Depression;Methods;mindfulness;Modeling;models and simulation;mortality;Myocardial Infarction;New Zealand;Norway;Not Hispanic or Latino;Operations Research;optimism;outcome disparities;Overdose;Pathway interactions;Persons;Population;pre-exposure prophylaxis;preference;prevent;preventable death;Prevention;Preventive care;preventive intervention;Primary Care;Primary Prevention;Process;Race;recruit;Research;response;Risk;safety net;Sampling;screening;sex;sexual risk taking;social;Socioeconomic Status;Specific qualifier value;Stroke;Substance Use Disorder;Suicide;Sweden;System;Target Populations;Testing;Time;Tobacco use;Training Programs;Travel;trend;United States;Visit;Work;young mother

PROJECT_TITLE: Can a radical transformation of preventive care reduce mortality by 20% in low SES populations? Preparatory work focusing on AUD/heavy alcohol use, HIV risk, and cardiovascular risk


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_DEPT: NEUROSCIENCES

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Project Narrative Microglia, the brain resident macrophages, exist in unique activation states that have been implicated in modulating Alzheimer’s disease (AD) risk; however, the regulation of these states and their impact on AD progression is incompletely understood. We found that expression level of the transcription factor PU.1 plays an important role in regulating microglia gene expression in an amyloid mouse model of AD and that low expression is associated with neuroprotective phenotypes. In this proposal I will address the regulation of microglia activation states by PU.1 dosage and its potential downstream protective mechanisms during amyloid pathology.

PI_NAMEs: CROWLEY, JESSICA  (contact)

PROGRAM_OFFICER_NAME: SARE, RACHEL

PROJECT_TERMS: Address;Adopted;Aging;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease risk;Amyloid;amyloid pathology;Amyloidosis;Animals;Attenuated;attenuation;Brain;Brain region;Cells;Characteristics;Complement;Complement Activation;Data;Disease;Disease associated microglia;disease model;Disease Progression;disorder risk;dosage;Environment;Exhibits;functional outcomes;Gene Expression;Gene Expression Profile;Genes;Genetic;genetic approach;Genetic Transcription;genome wide association study;glial activation;Goals;Health;Heterogeneity;Human;immune function;Immune signaling;Immunofluorescence Immunologic;In Situ Hybridization;In Vitro;Inflammation;Inflammatory;Inflammatory Response;Interferons;lipid metabolism;Location;Lymphoid;Macrophage;Mediating;Microglia;Modeling;mouse model;Mus;Myelogenous;Myeloid Cells;neural;Neurons;neuroprotection;novel;Nucleic Acid Regulatory Sequences;Outcome;Pathogenesis;Pathologic;Phagocytosis;Phenotype;Play;Population;prevent;Production;programs;protective effect;protein expression;Proteins;proto-oncogene protein Spi-1;recruit;Regulation;response;ribosome profiling;Role;Senile Plaques;Signal Transduction;Signaling Molecule;single nucleus RNA-sequencing;Synapses;Testing;Tissues;transcription factor;Transcriptional Regulation;Variant;Work

PROJECT_TITLE: Transcriptional regulation of neuroprotective microglia subtypes in health and disease


ORG_CITY: CLEVELAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

ORG_STATE: OH

PHR: NARRATIVE Castration-resistant prostate cancer is lethal and remains incurable, and the NCI-funded research program directed by Dr. Nima Sharifi seeks to understand mechanisms of resistance and identify new treatments. Our recently established Genitourinary Malignancy Research Center (GUMRC) is an interdisciplinary collaboration of research scientists and clinicians that focuses on understanding, diagnosing and treating bladder, kidney and prostate malignancy. This award will allow me to serve in complementary roles as a technical expert leading experiments in Dr. Sharifi's lab and Program Manager for the GUMRC.

PI_NAMEs: BERK, MICHAEL P. (contact)

PROGRAM_OFFICER_NAME: HILDESHEIM, JEFFREY

PROJECT_TERMS: Acceleration;androgen deprivation therapy;androgen independent prostate cancer;Androgen Receptor;Androgens;Animal Model;anti-cancer research;Award;bench to bedside;Bladder;Castration;Clinic;Clinical;Clinical Research;Common Neoplasm;Diagnosis;diagnostic tool;Doctor of Medicine;Ensure;experimental study;Foundations;Funding;Future;Genitourinary system;Goals;Hormones;Human Resources;IACUC;in vivo;Influentials;innovation;institutional biosafety committee;Institutional Review Boards;interdisciplinary collaboration;intratumoral androgen;Kidney;Knowledge;Laboratories;Laboratory Personnel;Localized Disease;Malignant neoplasm of prostate;Malignant Neoplasms;Medical Castration;Metastatic Prostate Cancer;Methods;Mus;new therapeutic target;Operative Surgical Procedures;Outcome;Pharmacotherapy;Postdoctoral Fellow;Preparation;programs;Prostate;prostate cancer cell;Protocols documentation;Receptor Signaling;Regulation;Research;Research Design;Research Personnel;Resistance;resistance mechanism;response;Role;Safety;Scientist;skills;Specialist;Steroids;Students;Technical Expertise;Techniques;Therapeutic;therapy resistant;Training;Translational Research;translational study;tumor progression;Urogenital Cancer;Work

PROJECT_TITLE: Translational science specialist in genitourinary cancers


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome;Infectious Diseases;Kidney Disease;Microbiome;Prevention;Urologic Diseases

PI_NAMEs: GHARAVI, ALI G (contact)

PROJECT_TERMS: 16p11.2;16S ribosomal RNA sequencing;Address;Animal Model;Benign;biobank;Biological Assay;BMP5 gene;Childhood;Chronic Kidney Failure;clinical care;clinical diagnosis;clinical phenotype;cohort;Cohort Studies;Collaborations;comorbidity;Complex;Computerized Medical Record;Copy Number Polymorphism;cost;Data;Diagnostic;diagnostic value;Disease;Dysuria;Effectiveness;Electronic Health Record;empowerment;Ensure;Event;exome;exome sequencing;experience;follow-up;Functional disorder;Funding;Genes;Genetic;genetic approach;Genetic Diseases;Genetic Predisposition to Disease;genetic testing;genetic variant;genome sequencing;genome wide association study;genomic data;Genomics;Homeostasis;Human Genetics;improved;insight;Investigation;Literature;Longterm Follow-up;Lower urinary tract;lower urinary tract symptoms;malformation;Measurement;Metabolic;microbial community;microbial genomics;microbiome;microbiota;microbiota composition;microbiota profiles;Morbidity - disease rate;National Human Genome Research Institute;National Institute of Diabetes and Digestive and Kidney Diseases;novel;Obstruction;Outcome;Pathogenesis;Pathway interactions;patient subsets;Patients;Pelvic floor structure;phenome;Phenotype;Population;proband;Ptosis;Questionnaires;rare variant;Reflux;Research;response to injury;Risk;Risk Factors;Role;Sampling;sex;Shapes;Signal Transduction;Single Nucleotide Polymorphism;Symptoms;Technology;trait;urinary;Urinary Incontinence;Urinary Microbiome;Urinary tract infection;Urine;urologic;Urology;Urothelium;Variant;Vesico-Ureteral Reflux;Visit;WNT5A gene;Work

PROJECT_TITLE: Human genetic approaches to lower urinary tract phenotypes


ED_INST_TYPE: SCHOOLS OF EDUCATION

NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric;Prevention

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative We know the early social-communication skills of children with ASD is one of the best predictors of later outcomes and often targeted in interventions; yet, current measures of social-communication skills designed for children with ASD do not easily allow for ongoing intervention progress monitoring. The proposed research is relevant to public health because by validating a novel outcome measure of key social-communication and language skills that is minimally burdensome to administer and sensitive to incremental change expected of young children with ASD, we may better monitor the effects of interventions.

PI_NAMEs: BOYD, BRIAN ANTONIO (contact)

PROGRAM_OFFICER_NAME: KAU, ALICE S

PROJECT_TERMS: Administrator;Adolescence;Adult;Adult Children;Age;Area;autism spectrum disorder;autism symptoms;autistic children;base;Behavior Therapy;Behavioral;behavioral phenotyping;blind;Characteristics;Child;Clinical Trials;Code;cognitive ability;Communication;Data;data visualization;design;Development;Diagnosis;Disabled Children;Early Intervention;effective intervention;Future;Goals;Growth;Impairment;improved;individuals with autism spectrum disorder;innovation;instrument;Intervention;intervention effect;Intervention Studies;joint attention;Language;Measurement;Measures;mobile application;Monitor;novel;Outcome;Outcome Measure;Parents;peer;Pharmacologic Substance;Play;Population;Populations at Risk;Positioning Attribute;Process;Prognosis;programs;Psychometrics;Public Health;Research;routine care;routine practice;Sampling;Site;skills;social;social communication;Sorting;sound;success;Symptoms;Time;tool;Translating;treatment effect;treatment trial;United States;Validation;validation studies;Validity and Reliability;Videotape;web platform

PROJECT_TITLE: Validation of an outcome measure of early social-communication for young children with ASD


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences

ORG_DEPT: NEUROSURGERY

PHR: NARRATIVE The inaccessibility of the brain in living people has confined molecular investigations of neuropsychiatric traits to postmortem tissue. Here, we address critical limitations that arise from this framework through (1) comprehensive, multiomic molecular profiling of living and postmortem human brain tissue and (2) integrating multiomics data with neuroimaging and neurocognitive data from the same individuals. At the center of this proposal is the Living Brain Project (LBP), wherein we survey a vast data landscape in individuals undergoing deep brain stimulation, including molecular data derived from bilateral biopsies from the dorsolateral prefrontal cortex. We anticipate fundamental advances in our understanding of the human brain will be made not only by the analyses proposed here but also by making this rich resource available to the larger scientific community.

PI_NAMEs: CHARNEY, ALEXANDER W (contact)

PROGRAM_OFFICER_NAME: PETANCESKA, SUZANA

PROJECT_TERMS: Address;Age;Alzheimer's disease related dementia;Autopsy;Bilateral;Biology;Biopsy;Brain;brain tissue;case control;cell type;Cells;Cessation of life;cohort;Cohort Analysis;Communities;Data;Data Analyses;Data Set;Deep Brain Stimulation;Dimensions;experimental study;Funding;Gender;Generations;Genome;genome-wide;Genomics;Genotype;Goals;Human;human subject;Individual;innovation;insight;Investigation;Knowledge;lipidome;lipidomics;Medical History;metabolome;metabolomics;Modernization;Molecular;Molecular Biology;molecular modeling;Molecular Profiling;multimodal neuroimaging;Multiomic Data;multiple omics;Neurobiology;Neurocognitive;neuroimaging;neuropathology;neuropsychiatry;Output;Participant;Pathogenesis;Persons;Phenotype;Play;Prefrontal Cortex;Procedures;Process;Proteome;Proteomics;Quality Control;Resolution;Resources;Role;Sampling;single-cell RNA sequencing;Site;Specimen;Structure;Surveys;Tissues;trait;transcriptome;transcriptome sequencing;transcriptomics;Uncertainty;virtual;Work

PROJECT_TITLE: A multiscale investigation of the living human brain

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Diabetes;Digestive Diseases;Liver Disease;Nutrition

ORG_CITY: SAINT LOUIS

ORG_DEPT: PEDIATRICS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: The liver controls whole-body metabolism, and disease states such as pre-diabetes, type 2 diabetes and non- alcoholic fatty liver disease arise from disorders in liver metabolism. We identified a critically important sugar transporter that regulates liver metabolism, and a naturally-occurring disaccharide that acts upon this sugar transporter to improve liver and whole-body metabolism, including enhancing the body’s ability to burn calories and to dispose of fat within the liver. The goal of this project is to understand precisely how this sugar transporter regulates liver and whole-body metabolism, and to define the mechanism of action of our index drug to inform new, safe therapies against diabetes and fatty liver disease.

PI_NAMEs: DEBOSCH, BRIAN JESSE (contact)

PROJECT_TERMS: Abate;Acute;adenylate kinase;Attenuated;Autophagocytosis;Biochemical;Calories;Carbohydrates;cardiovascular risk factor;Cardiovascular system;Cell membrane;Cessation of life;chronic liver disease;Data;defined contribution;Deoxyglucose;Development;Diabetes Mellitus;Diet;dietary;Disaccharides;Disease;established cell line;Exhibits;Extrahepatic;Fasting;fasting glucose;Fatty acid glycerol esters;Fatty Liver;fatty liver disease;FGF21 gene;fibroblast growth factor 21;Gene Deletion;Genetic;Germ Lines;Glucose;glucose transport;Glucose Transporter;Goals;Hepatic;Hepatocyte;Homeostasis;Imaging Techniques;improved;In Vitro;in vivo;in vivo imaging;indexing;Individual;inhibitor;Insulin Resistance;Intravenous;Kidney;Kinetics;knock-down;Knock-out;late endosome;Ligands;Liposomes;Liver;Liver diseases;liver metabolism;Location;Lysosomes;Mass Spectrum Analysis;Measures;Mediating;Metabolic;Metabolic Diseases;Metabolic Pathway;Metabolic syndrome;Metabolism;Microscopic;mimetics;Modality;mouse model;Mus;mutant;Mutant Strains Mice;non-alcoholic fatty liver disease;Non-Insulin-Dependent Diabetes Mellitus;novel;novel strategies;Oral;Overnutrition;Pathway interactions;Peripheral;Pharmaceutical Preparations;pharmacologic;Phenotype;Prediabetes syndrome;prevent;Radiolabeled;receptor;Regulation;Resistance;response;Retina;Role;Signal Transduction;SLC2A1 gene;Steatohepatitis;Substrate Specificity;sugar;Testing;Therapeutic Effect;therapeutic target;Thermogenesis;Time;Trehalase;Trehalose;Whole Organism

PROJECT_TITLE: Leveraging glucose transport and the adaptive fasting response to modulate hepatic metabolism

STUDY_SECTION: NMHD

STUDY_SECTION_NAME: Nutrition and Metabolism in Health and Disease Study Section[NMHD]


ADMINISTERING_IC: HG

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE Many human diseases are the result of defects in developmental processes that occur during gestation or in early life. In order to improve our understanding of the developmental origins of disease, it is essential to have a rigorous understanding of the normal processes of human development. This study will provide essential data to better understand human development by providing insight into which molecular changes are conserved among primate species and which are human-specific.

PI_NAMEs: ARDLIE, KRISTIN ;CONRAD, DONALD F. (contact);FENG, GUOPING ;SESTAN, NENAD

PROGRAM_OFFICER_NAME: ARGUELLO, ALEXANDER

PROJECT_TERMS: Address;Adult;analysis pipeline;animal colony;Animals;ATAC-seq;Atlases;Biological Specimen Banks;Biology;Brain;Breeding;Callithrix;Callithrix jacchus jacchus;Cebidae;Cells;Cercopithecidae;ChIP-seq;Communication;Communities;comparative genomics;Comparative Study;Data;Data Analyses;data integration;Databases;Defect;Development;Developmental Process;Disease;Dissection;Elements;epigenetic profiling;Equipment and supply inventories;Fetus;Gene Expression Profile;Gene Expression Profiling;Generations;Genes;Genetic;Genomics;Genotype;Genotype-Tissue Expression Project;Hi-C;Human;Human Development;human disease;improved;Individual;Infrastructure;insight;Laboratories;Life;Macaca;Macaca mulatta;Maps;Modeling;Molecular;multiple omics;nonhuman primate;Oregon;Pan troglodytes;Papio;Partner in relationship;Pathology;Pattern;Positioning Attribute;postnatal;Pregnancy;prenatal;Primates;Process;programs;Protocols documentation;Research;Research Personnel;research study;Resources;Rhesus;RNA analysis;Sampling;Scientist;single cell analysis;Small Nuclear RNA;Specific qualifier value;Standardization;Techniques;Testing;Time;tissue resource;Tissue Sample;Tissues;Transcript;transcriptome sequencing;transcriptomics;United States National Institutes of Health;Universities;usability

PROJECT_TITLE: Multispecies NHP dGTEx Research Center


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Digestive Diseases;Genetics;Human Genome;Immunization;Immunotherapy;Orphan Drug;Pancreatic Cancer;Rare Diseases;Vaccine Related

PHR: Narrative Pancreatic cancer has a highly desmoplastic stroma which is enriched with activated stellate cells and hyaluronic acids that contribute to the cancer’s poor prognosis. This project will test novel immunotherapy combinations targeting stromal signaling pathways in combination with immune checkpoint inhibitors in pancreatic cancers. Findings will provide novel strategies for testing combinations of stromal targeting agents with neoantigen- targeting approaches, epigenetic modifying approaches, and monocyte modulating immune checkpoint inhibitors in pancreatic cancer patients.

PI_NAMEs: ZHENG, LEI  (contact)

PROJECT_TERMS: Allogenic;AMD3100;anti-PD-1;anti-PD1 antibodies;anti-tumor immune response;Antibodies;Antigen Targeting;antigen-specific T cells;Ants;Bioinformatics;Biometry;CD44 gene;Cells;checkpoint therapy;Clinical Trials;Collaborations;Combination immunotherapy;CXCR4 gene;CXCR4 Signaling Pathway;Cytometry;cytotoxic;Data;Desmoplastic;effector T cell;Epigenetic Process;Epithelium;exhaustion;Fibroblasts;Flow Cytometry;Focal Adhesion Kinase 1;Future;Granulocyte-Macrophage Colony-Stimulating Factor;Granzyme;GVAX Cancer Vaccine;Human;Hyaluronic Acid;Hyaluronic Acid Binding;Hyaluronidase;Immune;Immune checkpoint inhibitor;Immune System Diseases;Immunohistochemistry;immunoregulation;Immunotherapy;improved;infiltrating duct carcinoma;Infiltration;inhibitor;Interferon Type II;kinase inhibitor;Malignant neoplasm of pancreas;Malignant Neoplasms;Measures;Mediating;Memory;Modeling;Monitor;monocyte;mouse model;Mus;Myelogenous;Myeloid Cells;Myeloid-derived suppressor cells;Neoadjuvant Therapy;neoantigen vaccine;neoantigens;neoplastic cell;novel;novel strategies;Operative Surgical Procedures;pancreatic cancer patients;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma model;pancreatic stellate cell;Pathway interactions;Patients;PD-1 inhibitors;peripheral blood;Phenotype;Phosphorylation Inhibition;Play;Production;Prognosis;programmed cell death protein 1;Publications;receptor;Recombinants;recruit;Regulatory T-Lymphocyte;Resectable;response;Role;Signal Pathway;Signal Transduction;single-cell RNA sequencing;small molecule inhibitor;Sorting;stellate cell;Stromal Cell-Derived Factor 1;Suppressor-Effector T-Lymphocytes;synergism;T cell infiltration;T cell receptor repertoire sequencing;T memory cell;T-Lymphocyte;targeted agent;Technology;Testing;trafficking;transmission process;tumor;Tumor Bank;Tumor Immunity;tumor microenvironment;Tumor-associated macrophages;ultrasound;Vaccines

PROJECT_TITLE: Integration of stromal targeting agents with immune checkpoint therapy


PI_NAMEs: MENDELSOHN, CATHY LEE (contact)

PROJECT_TERMS: Acute;Adipose tissue;Agonist;ATAC-seq;Bacteria;Basal Cell;Benign;Biology;Biomedical Research;bladder pain;Blood;Cell Differentiation process;cell type;Cells;Chad;Chemistry;Chronic;Clinical Research;Collaborations;Communities;Control Locus;Data;differentiation in vitro;Disease;Down-Regulation;Duct (organ) structure;Education and Outreach;Enterobacteria phage P1 Cre recombinase;Epithelium;Event;experience;Functional disorder;Funding;Genes;Genetic;genetic testing;Genetic Transcription;Genome;genome wide association study;Goals;Heme;Heme Iron;Herpesviridae;Homeostasis;Human;Immune;In Situ;Incontinence;Infection;Inflammation;Injury;insight;Insulin;Intestines;Invaded;Iron;iron metabolism;Kidney;Ligand Binding;lipid biosynthesis;Liver;Lower urinary tract;Macrophage;Malignant neoplasm of urinary bladder;Maryland;Medical Students;member;Metabolic;microbial genomics;microbiome;Mission;Modeling;Mus;Muscle;mutant;Mutation;Natural regeneration;notch protein;Notch Signaling Pathway;Nuclear Receptors;Nutrient;Obstruction;Organoids;Outcome;Pathogenesis;Pathway interactions;Patients;Pelvic floor structure;Placenta;Population;PPAR gamma;preclinical study;prevent;programs;Proteins;Ptosis;receptor;Regulation;repaired;Research;Research Personnel;Research Project Grants;response;response to injury;Retinoids;Role;rosiglitazone;Scientist;Shapes;Signal Pathway;Signal Transduction;Specific qualifier value;Squamous Differentiation;stem cells;Stretching;Students;summer program;symposium;Testing;Tissues;Toxin;Training;Transcriptional Regulation;transcriptome sequencing;undergraduate student;Universities;Up-Regulation;urinary;Urinary Microbiome;Urogenital Diseases;urogenital tract;urologic;Urology;Urothelial Cell;Urothelium;VP 16;Water;Wisconsin;Work

PROJECT_TITLE: Transcriptional regulation of urothelial differentiation and cell type specification during homeostasis and regeneration


ORG_CITY: SACRAMENTO

ORG_NAME: CALIFORNIA STATE DEPT/FOOD/AGRICULTURE

PHR: Project Narrative RFA-FD-22-006 The mission of California Department of Food and Agriculture’s (CDFA) Egg Safety and Quality Management Program (ESQM) is to ensure that eggs sold in California are of known quality, origin, grade, and size and support the consumption of high quality, safe eggs. The implementation of the Egg Regulatory Program Standards (ERPS) will provide ESQM with a uniform plan to consistently evaluate and improve egg safety inspection programs to achieve the long-term goal of a sustainable standards program.

PI_NAMEs: ABBOTT, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: NIESEN, MARIBETH

PROJECT_TITLE: California Department of Food and Agriculture, Egg Safety and Quality Management Program application for Conformance with the Egg Regulatory Program Standards, Cooperative Agreement.


NIH_SPENDING_CATS: Cancer

ORG_DEPT: SURGERY

PHR: NARRATIVE Tumors are complex entities that interact and coevolve with non-tumor cells, a major driving force for therapy resistance. This evolution is not random, but follows well-structured patterns. The recent development of single- cell technologies and novel quantitative approaches is creating the opportunity to uncover the principles of this coevolution and to develop therapeutic strategies to address this complexity.

PI_NAMEs: RABADAN, RAUL  (contact)

PROGRAM_OFFICER_NAME: DUECK, HANNAH RUTH

PROJECT_TITLE: Towards a quantitative understanding of tumor evolution


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics;Infectious Diseases

ORG_CITY: SALT LAKE CITY

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE Pathogens directly impact individual survival and thus strongly influence the genetics of host populations, providing a model for studying evolutionary processes of adaptation. In this proposal, we investigate the impact of host-pathogen interactions on human and non-human primate genomes focusing on admixed human and non-human primate populations and copy number variation. This work will reveal new patterns of natural selection and phenotypic associations at genes involved in recent battles against infectious pathogens.

PI_NAMEs: LEFFLER, ELLEN  (contact)

PROGRAM_OFFICER_NAME: ADKINS, RONALD

PROJECT_TERMS: Admixture;Area;Base Sequence;Biological Models;blood group;Blood typing procedure;Communicable Diseases;Copy Number Polymorphism;Data Set;driving force;fitness;Gene Cluster;Gene Family;Gene Frequency;Genes;Genetic;Genetic Variation;Genome;genomic data;genomic signature;genomic variation;Genomics;host-pathogen coevolution;Human;Individual;insight;Learning;Macaca;method development;Methods;Natural Selections;nonhuman primate;novel strategies;paralogous gene;pathogen;Pattern;Phenotype;Point Mutation;Population;pressure;Primates;Process;Recording of previous events;Research;Research Project Grants;Southeastern Asia;Study models;Testing;tool;Variant;Work

PROJECT_TITLE: Genomic signatures of primate-pathogen interactions

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-GGG-S(55)R]


PI_NAMEs: BARASCH, JONATHAN M. (contact)

PROJECT_TERMS: Affect;Affinity;Animals;apical membrane;Astronomy;Autoradiography;Back;Bacteria;Biliverdine;Biological Assay;Biology;Biomedical Engineering;Bladder;Bladder mucosa;Bladder Urothelium;Carbon Monoxide;Carrier Proteins;Cell division;Cells;Chelating Agents;chelation;Chemicals;Chemistry;Child;circadian pacemaker;Circulation;Citrates;Clinic;Communication;Complex;CRISPR/Cas technology;Crystallography;Cytolysis;Data;DNA biosynthesis;DNA metabolism;Drug Metabolic Detoxication;Duct (organ) structure;Endocytic Vesicle;Enterobactin;Enzymes;Epithelial Cells;Epithelium;Event;Evolution;experimental study;Gene Deletion;Generations;Genes;Genetic;Growth;Hematuria;Heme;Heme Iron;Homeostasis;host-microbe interactions;Human;Imaging Device;Immune;in vivo;Infection;inorganic phosphate;Invaded;invention;Iron;Iron Chelating Agents;Iron Chelation;Kidney;Klebsiella pneumoniae;Knockout Mice;LCN2 gene;Mammals;Measures;Mediating;Medicine;Metabolic;Metabolic Pathway;Metabolism;Metals;Methods;Microbe;Mucous Membrane;Mus;Mutation;Nature;novel;novel therapeutic intervention;Nutrient;Nutritional;Nutritional Immunity;Organ;Organism;Pathway interactions;Patients;pharmacologic;Phase;Physiological;Play;pressure;prevent;Process;Production;Productivity;Prostate;Proteins;Proteus mirabilis;Publications;Reporter;response;response to injury;RNA;Role;Science;Scientist;Series;Siderophores;small molecule;Source;Specialist;System;Testing;Theft;Time;tool;Toxic effect;trafficking;Transferrin;Ureter;Urethra;urinary;Urinary tract;Urinary tract infection;Urine;Urogenital Abnormalities;Urogenital Diseases;urogenital tract;Urology;Urothelial Cell;Urothelium;Visit;Water;Woman;Work

PROJECT_TITLE: A Novel Metabolic Pathway Regulates Urinary Tract Infections in the Bladder


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Pancreatic Cancer;Rare Diseases

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Administrative Core- Narrative The Administrative Core will provide organizational and administrative management, facilitate scientific collaborations and oversight, and coordinate scientific and advisory board meetings. Drs. Jaffee and Laheru will monitor the progress of each project and core, ensure communication and collaboration of projects through regular meetings, and assist with any challenges or hurdles that may arise. The administrative assistant to Drs Jaffee and Laheru will oversee the distribution and usage of funding, financial reporting, renewal applications and manuscript preparation and submission.

PI_NAMEs: JAFFEE, ELIZABETH M. (contact)

PROJECT_TERMS: Cancer Center;Clinical Cancer Center;clinical care;Clinical Research;Clinical Trials;Collaborations;Communication;Comprehensive Cancer Center;Conduct Clinical Trials;Dreams;Ensure;experience;Feedback;Funding;Goals;Grant;Group Meetings;Human;Immune System Diseases;Individual;Malignant neoplasm of gastrointestinal tract;Malignant neoplasm of pancreas;Malignant Neoplasms;Manuscripts;meetings;member;Monitor;Office of Administrative Management;pancreatic cancer patients;pre-clinical;Preparation;Principal Investigator;Problem Solving;Program Research Project Grants;programs;Reporting;Research Personnel;Research Project Grants;Resources;Role;Series;Site;success;Supervision;translational clinical trial;tumor immunology;United States National Institutes of Health;Universities;Update

PROJECT_TITLE: Administrative Core


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Autoimmune Disease;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Eye Disease and Disorders of Vision;Immunotherapy;Infectious Diseases

ORG_CITY: PROVIDENCE

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: Project Narrative  As PD-1 immune checkpoint blockade becomes a prevalent immunotherapeutic for treating cancer and chronic viral infections, the emergence of immune related adverse events highlights the importance of studying the effects of unleashing immune cell subsets in delicate organs like the salivary gland. I aim to elucidate the molecular mechanism by which PD-1 regulates CD8+ T cells in the salivary gland, and characterize the transcriptome and effector functions of the expanded CD8+ T cell population. I will also examine the potential immunopathological consequences of CD8+ T cell expansion in the PD-1 KO salivary gland by assessing histopathology and saliva secretions.

PI_NAMEs: BORYS, SAMANTHA  (contact)

PROGRAM_OFFICER_NAME: FUQUA, CHANTEL FAYSAN

PROJECT_TERMS: Acceleration;Animals;anti-PD-1;Autoantibodies;Autoimmune Diseases;Autoimmunity;autoreactivity;B-Lymphocytes;Biological Markers;cancer immunotherapy;career;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cell Count;Cells;Chronic;chronic infection;Colitis;Collaborations;cytokine;Cytomegalovirus;Cytomegalovirus Infections;cytotoxicity;Data;Deglutition;Denture Wear;Deterioration;Disease;Dry Eye Syndromes;Dryness;Esthesia;Exhibits;Exocrine Glands;experience;eye dryness;Frequencies;Functional disorder;Genetic;Gland;Histopathology;Human;Immune;immune activation;immune checkpoint;immune checkpoint blockade;Immune response;Immune system;immune-related adverse events;Immunology;immunopathology;Immunotherapeutic agent;In Situ;Infection;Infiltration;Inflammation;insight;International;irritation;Knockout Mice;Knowledge;Laboratories;Lacrimal gland structure;Life;Ligands;Lip structure;Lymphocyte;Malignant Neoplasms;Measurement;Measures;Mediating;Mentors;Modeling;Molecular;mouse model;Murid herpesvirus 1;Natural Killer Cells;Organ;Pathogenesis;Pathologic;Pathology;Patients;Play;Population;Preparation;preservation;prevent;Prevention;Production;programmed cell death ligand 1;programmed cell death protein 1;programs;Proliferating;Quality of life;receptor;Regulation;Research;Research Personnel;restraint;Rheumatism;Risk Factors;Role;Saliva;saliva secretion;Salivary;Salivary Glands;Self Tolerance;Seroprevalences;Signal Transduction;single cell analysis;single cell sequencing;Sjogren's Syndrome;skills;Sorting;symposium;Symptoms;Syndrome;T-Cell Proliferation;T-Lymphocyte;T-Lymphocyte Subsets;Taste Perception;Therapeutic;Tissues;Training;transcriptome;tumor;viral transmission;Virus;Virus Diseases;Virus Latency;Vitiligo;Woman;Work;Xerostomia

PROJECT_TITLE: PD-1 Mediated Regulation of Salivary Gland Integrity

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Genetics;Infectious Diseases;Microbiome

ORG_CITY: MADISON

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE Non-typhoidal Salmonella enterica sickens more than one million people each year in the United States. This proposal investigates how Salmonella responds to the sulfur metabolite, dimethyl sulfoxide (DMSO) to regulate gene expression and support enteric disease. An improved mechanistic understanding of how DMSO reduction pathways are regulated will guide the future development of therapeutics that reduce the metabolic versatility of Salmonella within the gut to improve human health.

PI_NAMEs: CRUZ, EDDY  (contact)

PROGRAM_OFFICER_NAME: ALEXANDER, WILLIAM A

PROJECT_TERMS: Acute;Anaerobiosis;Animal Model;Animals;Anoxia;Bacteria;bacterial genetics;Binding;Biochemical;Bioinformatics;Biological Models;career;Catabolism;Catalytic Domain;Cattle;Colon;commensal bacteria;Communicable Diseases;Communication;Complement;Data;Dedications;design;Diarrhea;Dimethyl Sulfoxide;dimethyl sulfoxide reductase;Disease;Doctor of Philosophy;Enteral;enteric infection;Enterobacteriaceae;Enterocolitis;Epithelium;Escherichia coli;Escherichia coli K12;experimental study;Fellowship;fitness;Fluorescence Microscopy;foodborne;foodborne pathogen;Foundations;Fumarates;Future;Gastrointestinal Physiology;Gene Expression;Gene Expression Profiling;Genetic;genetic approach;Genetic Transcription;Genome;Growth;gut colonization;gut microbiota;Health;Homologous Gene;Human;Hypoxia;improved;In Vitro;in vivo;Infection;infectious disease model;Inflammation;intestinal epithelium;Intestinal Mucosa;Intestines;Ligation;Mediating;Mentorship;Metabolic;Metabolism;Microbiology;microbiota;Modeling;Molecular;mutant;neutrophil;next generation;Nitrates;non-typhoidal Salmonella;novel;Nucleic Acid Regulatory Sequences;Nutrient;Nutrient availability;Operative Surgical Procedures;Operon;Oxidants;Pathogenesis;Pathology;Pathway interactions;Persons;Phenotype;Physiological;Production;promoter;Proxy;Regulation;Regulon;Respiration;Salmonella;Salmonella enterica;Salmonella infections;Salmonella typhimurium;Scientist;Serotyping;Solid;Source;spatiotemporal;success;Sulfur;Systemic disease;Testing;therapeutic development;Tissues;Training;Transcriptional Regulation;transcriptome;transcriptome sequencing;United States;virulence gene;Work

PROJECT_TITLE: Differential regulation of three DMSO reductases during enteric salmonellosis


NIH_SPENDING_CATS: Brain Disorders;Cerebrovascular;Infectious Diseases;Malaria;Neurosciences;Rare Diseases;Vector-Borne Diseases

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

PHR: Project Narrative Microcirculatory dysfunction and vascular leak is a common disorder of hyper-inflammatory infectious diseases, such as malaria and sepsis. In this project, we will investigate the potential of kinase inhibitors to stabilize endothelial barrier properties and study kinase regulation of endothelial barrier integrity.

PI_NAMEs: SMITH, JOSEPH D (contact)

PROGRAM_OFFICER_NAME: PESCE, JOHN T

PROJECT_TERMS: 3-Dimensional;Binding;Biological Assay;Blood - brain barrier anatomy;Blood Vessels;Brain Edema;brain endothelial cell;Cell model;Cerebral hemisphere hemorrhage;Cerebral Malaria;cerebral microvasculature;Clinical;clinical application;Communicable Diseases;Complex;Complication;Disease;drug discovery;drug repurposing;Drug Targeting;Edema;efficacy evaluation;Endothelial Cells;endothelial dysfunction;Endothelium;Erythrocytes;Failure;Falciparum Malaria;Functional disorder;Goals;Human;Impairment;In Vitro;in vivo;Individual;Infection;Inflammation;Inflammatory;Inflammatory Response;inhibitor;Injury;innovation;kinase inhibitor;knock-down;Knowledge;lentiviral-mediated;Malaria;MATK gene;microbial;Modeling;Molecular;monolayer;mouse model;Mus;novel therapeutic intervention;Obstruction;Parasites;pathogen;Pathway interactions;Patients;Pharmaceutical Preparations;Phosphotransferases;Plasmodium falciparum;Property;PTK2 gene;Regression Analysis;Regulation;repaired;Sepsis;Signal Transduction;small hairpin RNA;src-Family Kinases;Stimulus;Systems Biology;Thrombin;Thrombosis;Time;Tissues;TNF gene;Variant;Viral Hemorrhagic Fevers;Work

PROJECT_TITLE: Mechanisms of endothelial dysfunction in cerebral malaria and barrier restorative pathways

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Orphan Drug;Pancreatic Cancer;Rare Diseases

ORG_CITY: BALTIMORE

PHR: Project Narrative The Clinical trials and Statistics Core (Core B) serves as a centralized resource to all pancreatic cancer P01 program investigators and promotes synergy across different projects and resources. It enhances the abilities of projects to address key scientific questions that will lead to a reduction in the morbidity and mortality associated with pancreatic cancer. The work of Core B is to ensure that clinical and laboratory studies are carried out using sound designs, and the results analyzed with appropriate methods in order to reach justifiable scientific conclusions.

PI_NAMEs: WANG, HAO  (contact)

PROJECT_TERMS: Address;Adherence;Animals;Back;Bioinformatics;Biological Markers;Biology;Biometry;Biostatistics Core;Cancer Biology;Clinic;Clinical Data;Clinical Research;Clinical Trials;Collaborations;Collection;Combined Modality Therapy;Communication Methods;complex data;computerized data processing;Conduct Clinical Trials;Consultations;Correlative Study;data acquisition;Data Analyses;Data Collection;data dissemination;Data Element;data exchange;data integration;data management;data quality;Databases;design;Development;electronic data capture system;Ensure;Equipment;Faculty;flexibility;Formulation;genomic data;Genomics;Goals;Good Clinical Practice;high throughput analysis;Human;Human Resources;Immune System Diseases;Immunologics;Immunotherapy;improved;in vivo evaluation;Informatics;Infrastructure;innovation;Institutional Review Boards;Investigational Drugs;Investigational New Drug Application;Laboratories;laboratory experiment;Laboratory Finding;Laboratory Study;Learning;Link;Malignant neoplasm of gastrointestinal tract;Malignant neoplasm of pancreas;Manuscripts;medical schools;meetings;member;Methodology;Methods;molecular marker;Monitoring Clinical Trials;Morbidity - disease rate;mortality;multidimensional data;Oncology;Pancreatic Adenocarcinoma;Patient-Focused Outcomes;Patients;Positioning Attribute;preclinical study;preclinical trial;Preparation;Process;Program Research Project Grants;programs;Protocols documentation;Publications;Quality Control;Research;Research Design;Research Personnel;Research Project Grants;Resources;Running;Science;Secure;Service Statistics;Services;sound;Specialist;Specific qualifier value;Statistical Models;statistical service;statistics;stem;synergism;Techniques;Testing;therapeutic target;tool;Toxic effect;translational study;Translations;Universities;Work

PROJECT_TITLE: Core B: Clinical Trials and Statistics


NIH_SPENDING_CATS: Clinical Research

ORG_CITY: MIAMI

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: FLORIDA INTERNATIONAL UNIVERSITY

PHR: Project Narrative Project iCREATE (investigating Career & Research Experience Access Through Evidence) will address the lack of diversity in biomedical careers by designing, implementing, and testing, two scalable and innovative interventions; as well as investigating the effect of various research and career development experiences on students' career goals, career strategies, and key student career intent and action outcomes. The desired outcome is to enhance the evidence base for effective interventions and contribute to the growing knowledge on elements that impact underrepresented minority students' intent and preparation to pursue biomedical research careers.

PI_NAMEs: LIBERLES, JESSICA  (contact);MCCARTNEY, MELISSA R

PROGRAM_OFFICER_NAME: NELSON, SHAKIRA M

PROJECT_TERMS: Area;Awareness;Biological Sciences;Biology;Biomedical Research;career;career awareness;career development;career preparation;Communities;comparative;Degree Completion;demographics;design;Educational Curriculum;Educational workshop;effective intervention;Effectiveness;effectiveness evaluation;Elements;Ensure;equity, diversity, and inclusion;evidence base;Evidence based program;experience;Florida;Fostering;Goals;Hispanic;Improve Access;Individual;innovation;Institution;Intention;interest;International;Internships;Intervention;Knowledge;knowledge base;Longitudinal Studies;Measures;medical schools;Minority;Minority Groups;Minority-Serving Institution;Modeling;Motivation;novel;Outcome;Ownership;Pathway interactions;Patient Self-Report;Positioning Attribute;Preparation;Research;research and development;Research Design;Rest;satisfaction;Science;skills;Student Selections;Students;success;Testing;Training;undergraduate research;undergraduate research experience;undergraduate student;Underrepresented Minority;underrepresented minority student;Underrepresented Populations;Underrepresented Students;Universities;Work

PROJECT_TITLE: Investigating Career & Research Experience Access Through Evidence (iCREATE)


NIH_SPENDING_CATS: Autoimmune Disease;Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Infectious Diseases;Rare Diseases

ORG_CITY: PULLMAN

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: WASHINGTON STATE UNIVERSITY

PHR: PROJECT NARRATIVE Survivors of Ebola virus disease report having symptoms beyond recovery from infection, often severe enough to interfere with daily life. These symptoms, collectively termed Post-Ebola Syndrome (PES), range from musculoskeletal to neurological manifestations, yet the cause of PES development is unknown. This proposal aims to uncover the role of antibody-mediated immune effector function in the development of PES, thereby identifying potential therapeutic targets for the treatment/prevention of PES.

PI_NAMEs: VELAZQUEZ, JALENE  (contact)

PROGRAM_OFFICER_NAME: MOITRA, KAROBI

PROJECT_TERMS: 2019-nCoV;Acute;Antibodies;Antibody Response;Antigen-Antibody Complex;Antigens;Arthralgia;Autoantibodies;Autoantigens;Autoimmune;Autoimmune Diseases;autoimmune inflammation;Autoimmunity;Binding;Biological Assay;biophysical properties;cell type;Cells;Chaperonin 60;chemokine;Clinical;Cognition;cohort;Collaborations;Complement;cytokine;Data;Deposition;Development;Disease;Disease Outbreaks;ds-DNA;Ebola;Ebola Hemorrhagic Fever;Ebola virus;effective therapy;Epidemic;experience;experimental study;extracellular;Eye;falls;Fc domain;Fc Receptor;Filovirus;Glycoproteins;Goals;Histones;Household;Human;Humoral Immunities;IgG1;Immune;immune activation;Immunodominant Antigens;Immunology;Incubated;Individual;Infection;Inflammatory;Influenza;Interferon alpha;Life;Long COVID;long-term sequelae;Measures;Mediating;Mentors;monocyte;mRNA Expression;Musculoskeletal;Myalgia;nano-string;Natural Killer Cells;Neurologic Symptoms;neutrophil;new therapeutic target;NK Cell Activation;novel;Pathogenesis;Pathogenicity;Pathologic;Pathology;patient mobility;Patients;Phagocytosis;Polysaccharides;Predisposition;Prevention;programs;Property;Proteins;Quality of life;Recombinants;Recovery;recruit;Reporting;Research;Resolution;Role;SARS-CoV-2 infection;Scientist;Seminal fluid;seropositive;Serum;Severities;Shapes;Sierra Leone;Site;skills;Specificity;Structure;Survivors;Symptoms;Syndrome;therapeutic target;therapeutic vaccine;Time;Tissues;Training;Universities;Viral;viral RNA;virology;Virus;Virus Diseases

PROJECT_TITLE: Defining the protective or pathologic role of antibodies in Post-Ebola Syndrome


ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

ORG_STATE: MA

PHR: Project Narrative The Severe Chronic Neutropenia International Registry (SCNIR) is a research resource that supports the study of the diagnosis, genetics, treatment, and outcomes for patients with very low blood neutrophil counts, a type of immunodeficiency predisposing patients of all ages to severe bacterial infections. With support from NIAID, work from the SCNIR has guided clinical care of patients with SCN, advanced our scientific understanding about neutrophils, and provided educational resources for patients and medical providers regarding this rare condition over the past 25 years. To move forward, we propose to move the SCNIR to Boston Children’s Hospital, with its outstanding infrastructure to modernize the database; partner with both physician and patient communities; generate deep clinical and genetic datasets for researchers; promote novel clinical trials; and provide resources for engagement and education of patients, medical providers, and disease advocacy groups.

PI_NAMEs: NEWBURGER, PETER E;SHIMAMURA, AKIKO  (contact)

PROGRAM_OFFICER_NAME: MORRIS FEARS, MARGARET A

PROJECT_TERMS: Abbreviations;Address;Adult;Advocacy;Age;arm;Bacterial Infections;Basic Science;Bibliography;Biocompatible Materials;Bioinformatics;Biology;Biometry;Book Chapters;Boston;Caring;Case Study;Childhood;Chronic;Clinical;clinical care;Clinical Data;clinical diagnostics;Clinical Medicine;clinical phenotype;Clinical Research;Clinical Trials;Clonal Evolution;cohort;Collaborations;Colony-Stimulating Factor Therapy;Communication;Communities;comorbidity;Computational Biology;computerized data processing;CRISPR/Cas technology;Data;Data Aggregation;Data Collection;data exchange;data integrity;Data Set;Databases;Development;Diagnosis;diagnostic tool;Disease;disease registry;editorial;Education;Education and Outreach;education resources;elastase inhibitor;evidence base;Evolution;experience;Family;family support;Feedback;Fostering;gene discovery;Genetic;Genetic study;genomic data;Genomics;Geography;Germ Lines;Granulocyte Colony-Stimulating Factor;Host Defense;Hybrids;immunodeficiency;Individual;Infection;Information Technology;Infrastructure;Innate Immune System;innovation;International;journal article;knockout gene;Leukocytes;Life;Link;Mediating;Medical;meetings;Modeling;Modernization;Molecular;Molecular Biology;National Institute of Allergy and Infectious Disease;Natural History;Natural Language Processing;Neutropenia;neutrophil;Newsletter;novel;operation;Outcome;Pathogenesis;Patient advocacy;Patient Care;Patient Education;patient engagement;patient oriented;Patient Outcomes Assessments;Patient-Focused Outcomes;Patients;Pediatric Hospitals;Physicians;Pilot Projects;Productivity;Provider;Published Comment;Publishing;rare condition;Rare Diseases;Recording of previous events;recruit;Registries;Research;Research Personnel;Resources;response;Risk;risk stratification;Science;social media;Somatic Mutation;Study models;Support Groups;System;technology development;translational approach;Translational Research;Update;WHIM syndrome;Work


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

PI_NAMEs: WILKINS, CONSUELO HOPKINS (contact)

PROJECT_TERMS: Academic Medical Centers;Address;African American;African American population;Asthma;Behavioral;Biological;Black Populations;Cardiovascular Diseases;Cause of Death;Cessation of life;Chronic;Chronic Disease;clinical practice;Collaborations;collaborative environment;Collection;Common Data Element;Communication;Communities;community engagement;Data;Data Collection;data harmonization;data integration;Data Science;data sharing;data standards;Development;Diabetes Mellitus;Discipline;disease disparity;Disparity;disparity reduction;Doctor of Philosophy;empowerment;Endocrinologist;Ensure;Equity;ethnic health disparity;ethnic minority;Evaluation;experience;Faculty;Genetic;Goals;Health;health data;Health Disparities Research;health disparity;health equity;Health Expenditures;Human;Human Resources;Hypertension;improved;Individual;informatics tool;Infrastructure;innovation;Institution;Intervention;Knowledge;Language;Latino;Latino Population;Leadership;Lived experience;Malignant Neoplasms;medical schools;Medicine;Methods;Minority;minority communities;minority engagement;Molecular;Monitor;National Institute on Minority Health and Health Disparities;novel;Obesity;Operating System;operation;Operative Surgical Procedures;Pilot Projects;Population;population health;Poverty;premature;preventable death;Problem Solving;Productivity;professor;programs;prospective;Quality of life;racial health disparity;racial minority;Research;Research Personnel;Research Project Grants;Resource Sharing;Resources;Risk Factors;Scientist;skills;social;social health determinants;Socioeconomic Status;Southeastern United States;Stephania;Structure;Technology;Testing;Time;tool;translational goal;translational scientist;Universities;Vision;Work

PROJECT_TITLE: Admin Core