ORG_CITY: NASHVILLE

ORG_STATE: TN

PHR: As a VA anesthesiologist and physiologist, I study desperately needed, novel strategies against cellular injury of vital organs including brain and heart, geared to help our often multi-morbid Veteran patients who are at a higher risk for heart attacks and, thus, cardiac arrest, a leading cause of debilitating illness and death world- wide. Even with the best resuscitation, >90% still have severe neurological deficits or die. Inhalation of the no- ble gas Argon during resuscitation offers an intriguing new therapy to improve neurologically favorable survival by so far unexplored mechanisms. Thus, the improved multi-pronged approach of this revised highly innovative proposal by a team of well-established physicians and scientists in resuscitation will help develop a completely novel, potentially game-changing therapeutic approach in cardio-cerebral resuscitation, that will be ready to be tested in clinical studies with the potential to significantly improve survival, functional recovery and quality of life in thousands of cardiac arrest patients, including Veterans, each year with otherwise very bleak outcomes.

PI_NAMEs: RIESS, MATTHIAS L. (contact)

PROJECT_TERMS: Action Potentials;Agonist;Anesthesia procedures;antagonist;Anti-Arrhythmia Agents;Argon;Arrhythmia;Arteries;Biological;Biological Assay;Blood flow;Blood Vessels;Board Certification;Brain;Carbon Dioxide;Cardiac;Cardiac Output;Cardiopulmonary Resuscitation;Cardiovascular system;Cell Death;cell injury;Cerebrum;Cessation of life;Chemicals;Circulation;Clinical Research;clinically relevant;Complement;conditioning;Data;Diameter;Electrons;Electrophysiology (science);Endothelium;experimental study;Family suidae;Heart;Heart Arrest;heart function;hemodynamics;high risk;improved;In Vitro;in vivo;Inhalation;Inhalation Anesthetics;Inhalation Drug Administration;inhibitor;innovation;Ion Channel;Ischemia;ischemic injury;Left;Light;Literature;Lung;Maps;Measures;Mechanics;Metabolic;Metabolism;Mitochondria;Modeling;Molecular;Myocardial Infarction;Myography;Nature;Nervous System Physiology;Nervous System Trauma;Neurologic;Neurologic Deficit;Neurological outcome;neuroprotection;Nitric Oxide;Nitric Oxide Synthetase Inhibitor;Noble Gases;novel;novel strategies;novel therapeutics;Operating Rooms;Optics;Organ;out-of-hospital cardiac arrest;Outcome;patch clamp;Pathway interactions;Patients;Perfusion;Peripheral;Peripheral Resistance;Physicians;pre-clinical;pressure;Property;Pulmonary Vascular Resistance;Pulmonary vessels;Quality of life;Rattus;receptor;Recovery;Recovery of Function;Regulation;Reperfusion Injury;Reperfusion Therapy;Research Personnel;Resistance;Resuscitation;Risk;Role;Safety;scale up;Science;Scientist;sevoflurane;Signal Transduction;Signaling Protein;Soluble Guanylate Cyclase;Survival Rate;Testing;Therapeutic;Vascular resistance;Vasodilation;ventilation;Ventricular Fibrillation;Veterans;Xenon

PROJECT_TITLE: Inhaled Argon during Cardiopulmonary Resuscitation -A Novel Therapy to Improve Vital Organ Function and Survival after Cardiac Arrest


ADMINISTERING_IC: AI

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Asthma;Biotechnology;Clinical Research;Genetics;Health Effects of Indoor Air Pollution;Lung

ORG_CITY: BALTIMORE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: The proposed research is relevant to public health because asthma, increasing in prevalence, represents a major national cost measured by both patient suffering and economic burden. Our studies proposed will provide a conceptual framework linking the environmental allergens, MRC1, and miR-511-3p to key features of asthma. In the long term, these studies may reveal novel therapeutic targets for allergy and asthma.

PI_NAMEs: GAO, PEISONG  (contact)

PROGRAM_OFFICER_NAME: MINNICOZZI, MICHAEL

PROJECT_TERMS: Affinity;airway hyperresponsiveness;airway inflammation;Allergens;Allergic;allergic airway inflammation;Allergic inflammation;Anti-Inflammatory Agents;Antigens;Asthma;asthma exacerbation;asthma model;asthmatic;Binding;Biological Assay;Biotin;Clustered Regularly Interspaced Short Palindromic Repeats;cockroach allergen;Collaborations;comparison control;conditional knockout;Cost Measures;Critical Care;Data Set;Defense Mechanisms;Dependovirus;Development;Dictyoptera;Economic Burden;environmental allergen;Environmental Exposure;Equilibrium;experimental study;Exposure to;extracellular vesicles;Extrinsic asthma;Genes;Genetic Transcription;Genome engineering;Goals;Human;human subject;Hypersensitivity;Immune response;Inflammatory;Inhalation;innovation;Knock-out;Knockout Mice;Link;LoxP-flanked allele;Luciferases;Lung;Macrophage;Mannose;mannose receptor;Mediating;Medicine;Messenger RNA;MicroRNAs;Molecular;mouse model;Mus;new therapeutic target;novel;novel diagnostics;overexpression;Patients;peripheral blood;Phenotype;Pilot Projects;Plasma;Polysaccharides;Prevalence;prophylactic;Prostaglandin D2;Public Health;Reporter;Research;Risk;Role;Sampling;Severities;Signal Pathway;Signal Transduction;Sputum;Testing;TLR4 gene;tool;Transcript;transcriptomics;Untranslated RNA

PROJECT_TITLE: Functional role of miR-511-3p in allergic asthma and its underlying mechanisms

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IMM-T(57)]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Atherosclerosis;Bioengineering;Biotechnology;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Congenital Heart Disease;Congenital Structural Anomalies;Heart Disease;Pediatric;Rare Diseases;Regenerative Medicine

ORG_CITY: COLUMBUS

ORG_NAME: RESEARCH INST NATIONWIDE CHILDREN'S HOSP

ORG_STATE: OH

PHR: PROJECT NARRATIVE Congenital cardiac anomalies are the most common birth defect and a leading cause of death in the newborn period. The most effective treatment for congenital cardiac anomalies is reconstructive surgery. Unfortunately, complications arising from the use of currently available vascular conduits are a significant cause of postoperative morbidity and mortality. The development and translation of an improved vascular graft, created from an individual’s own cells, with the ability to grow and remodel, holds great promise for advancing the field of congenital heart surgery and improving the outcomes of infants requiring surgical intervention.

PI_NAMEs: BREUER, CHRISTOPHER KANE (contact)

PROGRAM_OFFICER_NAME: BURNS, KRISTIN

PROJECT_TERMS: 4D MRI;Adopted;Adoption;Adverse event;Age;Angioplasty;Angiotensin Receptor;Animal Model;Autologous;Blood Vessels;Bone Marrow;Cardiac;Cause of Death;Cells;Child;Circulation;Clinical;clinical implementation;Clinical Research;Clinical Trials;Clinical Trials Design;Common Ventricle;Complication;Computer Models;confirmatory clinical trial;Congenital Abnormality;congenital heart abnormality;Congenital Heart Defects;Congenital Heart Surgery;cost;Coupled;Data;design;Development;Devices;Dose;Echocardiography;effective therapy;Electric Capacitance;experience;FDA approved;Generations;graft function;Growth;Heart Ventricle;Hospitals;Implant;improved;improved outcome;Incidence;Individual;infant outcome;Inferior vena cava structure;Institution;Intervention;Losartan;Magnetic Resonance Imaging;man;Measures;Methods;Modeling;Monitor;Mononuclear;Morbidity - disease rate;mortality;Multi-Institutional Clinical Trial;Neonatal Mortality;Operative Surgical Procedures;Patients;Performance;Pilot Projects;Postoperative Period;preclinical study;prevent;Process;process improvement;prospective;Protocols documentation;Pulmonary artery structure;rational design;Recommendation;Reconstructive Surgical Procedures;Repair Complex;repaired;Research Design;Resolution;Safety;scaffold;Series;Stenosis;Structure;surgery outcome;System;Technology;Testing;Time;Tissue Engineering;Translations;Tubular formation;Vascular Graft;vascular tissue engineering;Work

PROJECT_TITLE: A Study Evaluating the Safety and Efficacy of Second-Generation Tissue Engineered Vascular Grafts (TEVG2)


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: NEW ORLEANS

ORG_NAME: SOUTHEAST LOUISIANA VETERANS HEALTH CARE

ORG_STATE: LA

PHR: Post-traumatic stress disorder is characterized by persistent memories of traumatic events and inability to extinguish learned fear, is associated with reduced endocannabinoid signaling, and affects 13% of US veterans. Dysfunction of the endocannabinoid system causes impaired extinction and enhanced fear memory. Understanding how endocannabinoid in the cerebellar circuit controls the reconsolidation and extinction of fear memory may suggest novel pharmacological targets as therapeutic interventions for PTSD.

PI_NAMEs: LIU, SIQIONG JUNE (contact)

PROJECT_TERMS: 2-arachidonylglycerol;Acceleration;Affect;Amygdaloid structure;Animals;antagonist;Anxiety Disorders;Attenuated;Cerebellar Cortex;Cerebellar Nuclei;Cerebellum;Clinical Research;conditioned fear;defense response;designer receptors exclusively activated by designer drugs;Development;emotional behavior;endocannabinoid signaling;Endocannabinoids;endogenous cannabinoid system;Enzymes;Event;Exposure to;Extinction;Failure;fear memory;Fright;Functional disorder;Genetic Suppression;Human;Impairment;inhibitor;insight;Intervention;Investigation;Knowledge;Learning;learning extinction;Life Experience;Medial;Mediating;Memory;memory consolidation;Mental disorders;Mental Health;Metabolism;Monoacylglycerol Lipases;Mus;Neuronal Plasticity;Neurons;new therapeutic target;novel;Output;Patients;pharmacologic;Pilot Projects;Post-Traumatic Stress Disorders;PPAR alpha;Prefrontal Cortex;prevent;Process;Production;psychological trauma;Psychotherapy;Purkinje Cells;Regulation;Research;response;Role;Stimulus;Synapses;Technology;Testing;Therapeutic Intervention;Time;transcription factor;traumatic event;treatment strategy;Veterans

PROJECT_TITLE: The role of cerebellar endocannabinoids in the reconsolidation and extinction of fear memory

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 MHBA-J (01)]


ORG_CITY: SALISBURY

ORG_NAME: W G HEFNER VA MEDICAL CENTER

ORG_STATE: NC

PHR: NARRATIVE Dialysis vascular access is both the lifeline and the Achilles heel of hemodialysis. Our goal is to develop a disruptive new technology in the form of a bioengineered vessel whose structure and functionality can be modulated at will to fit the clinical setting, and so help patients with vascular access dysfunction.

PI_NAMEs: ROY-CHAUDHURY, PRABIR  (contact)

PROJECT_TERMS: Address;Anastomosis - action;Anatomy;Animals;Arteriovenous fistula;arteriovenous graft;Award;Bilateral;Biocompatible Materials;Biology;biomaterial compatibility;Biomedical Engineering;Biophysics;Blood Vessels;Breathing;Cannulations;Caring;Catheters;Cells;Characteristics;Clinical;clinical efficacy;clinically relevant;Collagen;Contralateral;Coronary;Data;design;Devices;Dialysis procedure;Diameter;economic cost;effective therapy;Elastin;Endothelial Cells;Engineering;Excision;experimental study;Failure;Family suidae;Feedback;Fiber;flexibility;Functional disorder;Future;Goals;Hemodialysis;hemodynamics;Histologic;In Vitro;Inguinal region;innovation;Intervention;Legal patent;Microscopic;military veteran;Morbidity - disease rate;morphometry;mortality;new technology;novel;Palmitates;Patients;Peripheral Vascular Diseases;poly(glycerol-sebacate);polycaprolactone;Polymers;porcine model;primary endpoint;Procedures;Process;process optimization;Property;prototype;Safety;safety assessment;scaffold;seal;Smooth Muscle Myocytes;Stenosis;stressor;Structure;Tensile Strength;Testing;Therapeutic;Thick;Toxic effect;United States;Uremia;Vein graft;Venous

PROJECT_TITLE: Hemodynamics, Uremia, Vascular Biology and Bioengineering: Creating the Ideal Hemodialysis Vascular Access

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 NEPH-N (01)]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Drug Abuse (NIDA only);Pediatric;Prevention;Substance Misuse;Substance Misuse Prevention;Underage Drinking

ORG_CITY: SANTA MONICA

ORG_NAME: RAND CORPORATION

ORG_STATE: CA

PHR: Project Narrative  The proposed study is particularly relevant because it attempts to improve adolescent drug and alcohol out- comes in the face of new drug threats—opioids, e-cigarettes, and legal marijuana. It is also relevant to study how to improve the implementation quality of drug prevention programs in schools because they play a central role in the lives of middle school youth in the US, and, up until now, schools have not been able to adopt and implement evidence-based drug prevention programs consistently. It is critical that schools effectively deliver high-quality programs to prevent adolescents from using drugs and alcohol in order to promote healthy adoles- cent development.

PI_NAMEs: CHINMAN, MATTHEW  (contact);PHILLIPS, ANDREA

PROGRAM_OFFICER_NAME: VAN VOORHEES, COURTE CHRISTIAN WIRTH

PROJECT_TERMS: Address;Adherence;Adolescent;adolescent alcohol and drug use;Adolescent Development;Adopted;Adult;Alcohol consumption;Alcohols;Attitude;Belief;Cigarette;cohort;Communities;community organizations;compare effectiveness;Control Groups;cost;Development;dosage;drug abuse prevention;Drug Prevention Program;drug quality;Drug usage;drug use behavior;economic outcome;Educational Curriculum;Effectiveness;effectiveness evaluation;Electronic cigarette;electronic cigarette use;Enrollment;Evaluation;evidence base;Evidence based program;follow-up;Friends;Funding;Future;Goals;high risk sexual behavior;Hour;Hybrids;implementation barriers;implementation determinants;implementation evaluation;implementation fidelity;implementation outcomes;improved;Individual;Intervention;Interview;junior high school;Knowledge;Legal;Manuals;Marijuana;marijuana legalization;Measures;Methods;Middle School Student;misuse of prescription only drugs;Monitor;novel therapeutics;online registry;Opioid;opioid use;Outcome;Participant;peer;Pharmaceutical Preparations;Play;prevent;Prevention;Prevention program;process evaluation;Prodrugs;programs;Public Health;Quasi-experiment;Randomized;Randomized, Controlled Trials;Recreation;reduced alcohol use;Research;Resistance;Resources;response;Risk;Risk Factors;Role;scale up;Schools;Self Efficacy;seventh grade;skills;Students;substance use;Substance Use Disorder;substance use prevention;System;teacher;Teacher Professional Development;Testing;Time;tool;Training;trend;Update;uptake;Violence;Youth

PROJECT_TITLE: Improving the Implementation of Evidence-based Drug Prevention Programs in Schools

STUDY_SECTION: CLHP

STUDY_SECTION_NAME: Community-Level Health Promotion Study Section[CLHP]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Brain Disorders;Cardiovascular;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Heart Disease;Hematology;Organ Transplantation;Pediatric;Rare Diseases;Stroke;Transplantation

ORG_CITY: Wilmington

ORG_NAME: NEW ENGLAND RESEARCH INSTITUTES, INC.

ORG_STATE: DE

PHR: PROJECT NARRATIVE This research study proposes to conduct a single-arm clinical trial in 22 children who are suffering from severe heart failure and require a mechanical heart pump as a bridge to a heart transplant. Unlike adult heart failure patients who have access to wide variety of safe and reliable heart pumps that permit hospital discharge, smaller children do not, leaving children and their families hospitalized for up to a year until a heart transplant becomes available. The purpose of this study to evaluate a promising new heart pump for smaller children, the Jarvik 2015, that closes this enormous technology gap between adult and pediatric devices, and to provide the type of safety and effectiveness data that the FDA requires to review and potentially approve a high-risk medical device for a rare/orphan disease, like children hospitalized for severe heart failure.

PI_NAMEs: MAGNAVITA, ASHLEY  (contact);ZAK, VICTOR

PROJECT_TERMS: abdominal wall;Adult;Adverse event;Anticoagulants;Applications Grants;arm;Artificial Heart;Berlin;Blood;blood pump;Cannulas;Child;Child Support;Childhood;Childhood stroke;Clinical;Clinical Data;Clinical Trials;cohort;Communities;Complication;Contracts;Data;Data Coordinating Center;data registry;data submission;design;Device Approval;Devices;Disease;Effectiveness;Epidemiology;Europe;European;Evaluation;Event;experience;Family;FDA approved;Feasibility Studies;flexibility;Freedom;Frequencies;Generations;Goals;Guidelines;Heart;Heart failure;Heart Transplantation;Hemolysis;high risk;Hospitalization;Hospitalized Child;Hospitals;Implant;improved;Incidence;Infection;Intravenous;Learning;left ventricular assist device;Life Expectancy;Magnetism;Medical;Medical Device;Monitor;Multi-Institutional Clinical Trial;National Heart, Lung, and Blood Institute;Nature;neuroimaging;operation;Outcome;Outcome Measure;Pathway interactions;Patient Discharge;Patients;pediatric heart failure;Performance;Persons;portability;preempt;Prevalence;prevent;Probability;Process;Protocols documentation;Publishing;Pump;randomized trial;Rare Diseases;Recording of previous events;Recovery;Refractory;Research;Research Personnel;research study;Resources;Role;Safety;safety assessment;Science;Site;Specific qualifier value;Standardization;Stroke;stroke risk;Technical Expertise;Technology;thrombogenesis;Thrombosis;Thrombus;Transplantation;Universities;Vulnerable Populations;Work;wound;wound healing

PROJECT_TITLE: 2/2 Circulatory Support in Pediatric Heart Failure Patients Using the Jarvik 2015 LVAD: A Pivotal Trial

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-Z (O1)]


NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Brain Disorders;Cardiovascular;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Heart Disease;Hematology;Organ Transplantation;Patient Safety;Pediatric;Rare Diseases;Stroke;Transplantation

ORG_CITY: STANFORD

ORG_DEPT: PEDIATRICS

ORG_NAME: STANFORD UNIVERSITY

PI_NAMEs: ALMOND, CHRISTOPHER  (contact);DAVIES, RYAN ROBERT;MAHLE, WILLIAM T

PROJECT_TERMS: abdominal wall;Adult;Adverse event;Anticoagulants;Anticoagulation;Applications Grants;arm;Artificial Heart;Berlin;Blood;blood pump;Cannulas;Child;Child Support;Childhood;Childhood stroke;Clinical;Clinical Management;Clinical Trials;cohort;Collaborations;Communities;Complication;Consultations;Contracts;Data;Data Coordinating Center;data registry;design;Development;Device Approval;Devices;Disease;Effectiveness;Epidemiology;Europe;European;Evaluation;Event;experience;Family;FDA approved;Feasibility Studies;Freedom;Frequencies;Generations;Goals;Guidelines;Heart;Heart failure;Heart Transplantation;Hemolysis;high risk;Hospitalization;Hospitalized Child;Hospitals;Implant;improved;Incidence;Infection;Information Dissemination;Infrastructure;Institutional Review Boards;Intravenous;Leadership;Learning;left ventricular assist device;Life Expectancy;Magnetism;Manuscripts;Medical;Medical Device;Monitor;Multi-Institutional Clinical Trial;neuroimaging;Neurologic;operation;Operative Surgical Procedures;Outcome;Outcome Measure;Pathway interactions;Patient Discharge;patient retention;Patients;pediatric heart failure;Performance;Persons;portability;preempt;Prevalence;prevent;Probability;Process;Productivity;Protocols documentation;Publishing;Pump;Pumpkins;randomized trial;Rare Diseases;Recording of previous events;Recovery;recruit;Refractory;Research;Research Personnel;research study;Role;Safety;safety assessment;Site;Site Visit;Specific qualifier value;Standardization;Stroke;stroke risk;Technology;thrombogenesis;Thrombosis;Thrombus;Transplantation;Universities;wound;wound healing

PROJECT_TITLE: 1/2 Circulatory Support in Pediatric Heart Failure Patients Using the Jarvik 2015 LVAD: A Pivotal Trial


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Assistive Technology;Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Rehabilitation;Serious Mental Illness

ORG_CITY: HOUSTON

ORG_DEPT: NEUROSURGERY

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: Project Narrative There is a large unmet need for developing new approaches to Treatment-Resistant Depression (TRD), a highly prevalent and debilitating disorder with major impact on public health. Clinical trials investigating deep brain stimulation (DBS), a neurosurgical approach widely used in neurological disorders, in the treatment of TRD have led to inconsistent results, possibly due to inadequate technology to precisely identify, target, and modulate the abnormal networks that mediate this disorder. The proposed studies will investigate the feasibility and safety of using a next-generation DBS system to “steer” stimulation simultaneously to two different brain regions implicated in TRD that may lead to new and better treatments for this and other severe neuropsychiatric disorders.

PI_NAMEs: GOODMAN, WAYNE K;POURATIAN, NADER ;SHETH, SAMEER ANIL (contact)

PROGRAM_OFFICER_NAME: FRANKOWSKI, MEGAN MICHELLE

PROJECT_TERMS: Address;Affect;Algorithms;Amygdaloid structure;Assessment tool;Basic Science;Beds;Behavior;Behavioral;Bilateral;Biological Assay;Blinded;Boston;Brain;Brain region;capsule;Chronic;Classification;Clinical;Clinical Trials;cognitive control;Computer Models;computerized;Data;Data Set;Deep Brain Stimulation;depressive symptoms;Device or Instrument Development;Devices;Diffusion;dimension reduction;disability;Disease;Dose;Double-Blind Method;Ecological momentary assessment;efficacy evaluation;Electrodes;Electroencephalography;Engineering;Epilepsy;Europe;Excision;Face;Functional disorder;Goals;Health Care Costs;Implant;improved;Individual;innovation;Inpatients;insight;Investigation;Lead;Literature;Mediating;Mental Depression;Modeling;Monitor;Negative Valence;Nervous System Disorder;network models;Network-based;neural circuit;Neurocognitive;neuropsychiatric disorder;neuroregulation;neurosurgery;next generation;novel;novel strategies;novel therapeutics;open label;Outcome;Outpatients;Patients;Pattern;Physiological;Physiology;Placebo Effect;Positive Valence;Process;Public Health;Randomized;rational design;Regional Anatomy;Research;response;Safety;safety and feasibility;Severities;Site;Source;Spatial Distribution;Stream;success;Symptoms;System;Technology;Testing;therapeutic evaluation;therapy development;tractography;treatment-resistant depression;Validation;Ventral Striatum;Withdrawal;Work

PROJECT_TITLE: Deep Brain Stimulation for Depression Using Directional Current Steering and Individualized Network Targeting


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Bipolar Disorder;Brain Disorders;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Mental Health;Mental Illness;Primary Health Care;Psychosis;Racial and Ethnic Minority Health Research;Schizophrenia;Serious Mental Illness

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE Latin American descended populations, which constitute the fastest growing ethnicity in the United States, are poorly represented in psychiatric genetics research. We will reverse this underrepresentation, accelerating discoveries and reducing health disparities by creating the Latin American Biobank for Severe Mental Illness (LAB-SMI), consisting of 50,000 SMI cases and 50,000 population controls ascertained by screening electronic medical records (EMR) from the Paisa region of Colombia. We will genotype and conduct genetic analyses of SMI in this 100K sample, and better characterize SMI through analyses of the longitudinal EMR.

PI_NAMEs: FREIMER, NELSON B. (contact);LOPEZ JARAMILLO, CARLOS ;OLDE LOOHUIS, LOES MARLEIN

PROGRAM_OFFICER_NAME: PEVSNER, JONATHAN ABRAM

PROJECT_TERMS: Acceleration;Affect;Age;Alleles;Architecture;Area;Behavior;biobank;Bipolar Disorder;Categories;cohort;Collaborations;Colombia;Communities;Computerized Medical Record;Copy Number Polymorphism;Data;data repository;Data Set;Databases;Delusions;demographics;Diagnosis;Diagnostic;Disease;disease phenotype;disorder risk;DNA;Equity;Ethnic Origin;Ethnic Population;Etiology;European;exome sequencing;Frequencies;Gender;Gene Frequency;Genes;Genetic;genetic analysis;Genetic Research;Genetic study;genome wide association study;genome-wide;genomic locus;Genotype;Geographic Locations;Goals;Grant;health disparity;Home;Hospital Records;Hospitals;improved;Individual;Interview;Investigation;Latin America;Latin American;Linkage Disequilibrium;Literature;longitudinal analysis;loss of function;Major Depressive Disorder;Maps;Medical;member;Mental Health;Meta-Analysis;Methods;Mining;Minor;Mood Disorders;novel;Participant;Persons;Pharmaceutical Preparations;phenome;Phenotype;phenotypic data;polygenic risk score;Population;Population Control;Predictive Value;Primary Care;primary care provider;primary care services;psychiatric genomics;Psychiatric Hospitals;psychogenetics;psychotic;Psychotic Disorders;rare variant;Recording of previous events;recruit;Reduce health disparities;Research;Research Design;Resources;Sampling;Schizophrenia;screening;severe mental illness;side effect;SNP array;SNP genotyping;Structure;Suicide attempt;Symptoms;Testing;trait;Transcend;treatment planning;United States;Variant

PROJECT_TITLE: A Latin American biobank for large-scale genetics research on severe mental illness

STUDY_SECTION: BGES

STUDY_SECTION_NAME: Behavioral Genetics and Epidemiology Study Section[BGES]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Bioengineering;Chronic Pain;Clinical Research;Pain Research;Physical Injury - Accidents and Adverse Effects;Physical Rehabilitation;Rehabilitation;Women's Health Research

ORG_CITY: PHILADELPHIA

ORG_DEPT: ORTHOPEDICS

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE  Achilles tendinopathy is a painful condition that does not fully resolve in 20-60% of patients following conservative treatment. In this study, we will determine rehabilitation loading profiles and ultrasound imaging biomarkers that explain tendon healing and functional outcomes in patients. We will also measure circulating levels of sex hormones to determine how variations in sex hormones impact tendon healing and outcomes.

PI_NAMEs: BAXTER, JOSH  (contact)

PROGRAM_OFFICER_NAME: PINTUCCI, GIUSEPPE

PROJECT_TERMS: achilles tendon;Acute;Affect;Age;Algorithms;Biomechanics;Biometry;Chronic;Clinic;Clinical;clinical care;clinical practice;Clinical Research;Data;Diagnosis;Diagnostic;Estradiol;Estrogens;Exercise;exercise rehabilitation;experience;Fatigue;Female;female sex hormone;Flexor;functional outcomes;Goals;Gonadal Steroid Hormones;Guidelines;healing;Health;Heel;Heterogeneity;hormonal contraception;Image;imaging biomarker;improved;innovation;instrument;Measurement;Measures;mechanical load;mechanical properties;mechanical stimulus;Mechanics;Modeling;Monitor;Muscle;Outcome;Outcome Measure;Pain;pain outcome;pain symptom;Palpation;Pathologic;Pathology;patient population;patient subsets;Patient-Focused Outcomes;Patients;Pattern;Physical therapy;pill;Preparation;primary outcome;Progesterone;Property;Prospective, cohort study;Protocols documentation;Recommendation;Recovery;reduce symptoms;Rehabilitation therapy;remote monitoring;Reporting;Research Design;Sampling;Serum;sex;Shoes;Stress;Structure;Subgroup;Symptoms;System;Techniques;Telemedicine;Tendinopathy;Tendon Injuries;Tendon structure;Testing;Time;Tissues;tool;Ultrasonography;ultrasound;Variant;Visit;wearable sensor technology;Woman;Work

PROJECT_TITLE: Tendon loading profiles that promote healing in Achilles tendinopathy

STUDY_SECTION: MRS

STUDY_SECTION_NAME: Musculoskeletal Rehabilitation Sciences Study Section[MRS]


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Health Services;Mental Health;Mental Illness;Prevention;Suicide;Suicide Prevention

ORG_CITY: ROCHESTER

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF ROCHESTER

ORG_STATE: NY

PHR: PROJECT NARRATIVE Effective, brief, low-cost interventions for individuals who attempt suicide are needed to save lives and achieve the goals of the National Strategy for Suicide Prevention. In response to a NIMH Notice of Interest, this time- sensitive proposal leverages an existing federal investment in Zero Suicide to test the effectiveness of a highly promising new treatment for recent suicide attempt survivors and learn how it works. If hypotheses are supported, the study will provide evidence of a brief, practical, and cost-effective therapy that reduces suicide reattempts in a real-world health setting.

PI_NAMEs: PISANI, ANTHONY R (contact)

PROGRAM_OFFICER_NAME: HAIM, ADAM J

PROJECT_TERMS: Accounting;Address;American;arm;Award;Belief;brief intervention;Caring;Clinical Sciences;clinical training;Collaborations;Communities;comparison control;cost;cost effective treatment;cost effectiveness;Cost Effectiveness Analysis;cost estimate;cost-effectiveness ratio;County;Data;design;Distress;Effectiveness;effectiveness evaluation;effectiveness research;effectiveness study;effectiveness testing;efficacy trial;Emergency medical service;Emergency Situation;Evaluation;experience;Feeling;Finland;follow-up;Funding;Future;Goals;Grant;group intervention;Health system;Healthcare Systems;hospital utilization;Human Resources;improved;incremental cost;incremental cost-effectiveness;Individual;inpatient service;insight;interest;Intervention;intervention cost;intervention program;Interview;Investigation;Investments;Leadership;Learning;Length of Stay;Loneliness;Manuals;Mediating;Mediation;Medical Records;Mental Health;Mental Health Services;Modeling;National Institute of Mental Health;New York;novel;novel therapeutics;Participant;Patient Education;patient engagement;Patients;Perception;Persons;programs;Protocols documentation;Provider;psychiatric inpatient;psychologic;Public Sector;Randomized;Randomized, Controlled Trials;Recovery;reducing suicide;Reporting;Request for Applications;Research;Research Personnel;Research Support;response;Risk Reduction;Safety;Services;Shame;Statistical Data Interpretation;suicidal;Suicide;Suicide attempt;Suicide prevention;suicide rate;Survivors;Sweden;Switzerland;System;Testing;theories;Therapeutic;Time;treatment arm;treatment as usual;treatment effect;treatment services;United States Substance Abuse and Mental Health Services Administration;Visit;Work;World Health

PROJECT_TITLE: Effectiveness of a Targeted Brief Intervention for Recent Suicide Attempt Survivors


NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: SEATTLE

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative The goal of this study is to gain insight into the mechanisms bacteria employ to defend themselves against antagonistic bacterial competitors. A greater understanding of these bacterial defenses will be beneficial for efforts to combat chronic, multispecies infections and in manipulation of human-associated microbial communities to promote health.

PI_NAMEs: MOUGOUS, JOSEPH DAVID (contact)

PROGRAM_OFFICER_NAME: UPADHYAY, MEENU MISHRA

PROJECT_TITLE: Mechanisms for sensing and responding to interbacterial antagonism

STUDY_SECTION: PCMB

STUDY_SECTION_NAME: Prokaryotic Cell and Molecular Biology Study Section[PCMB]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

PHR: Project Narrative. The survival of lung cancer patients is low if their blood platelets counts are high. Our study observed increased level of phosphatase in platelets from human and mice with cancer. We will test if disrupting phosphatase in platelets or in the extracellular environment reduces the spread of lung cancer.

PI_NAMEs: VIJAYAN, K. VINOD  (contact)

PROGRAM_OFFICER_NAME: AULT, GRACE S

PROJECT_TERMS: Acceleration;Adjuvant;Anoikis;anti-cancer research;anti-melanoma immunity;Aspirin;Attenuated;Biogenesis;Biological Markers;Blood;Blood Platelets;Bone Marrow;Cancer Biology;cancer cell;cancer immunotherapy;Cancer Patient;cancer survival;carcinogenesis;Cardiovascular Diseases;Catalytic Domain;Cause of Death;CD8-Positive T-Lymphocytes;Cell Lineage;Cell Survival;chemotherapeutic agent;clopidogrel;Coculture Techniques;Colon Carcinoma;Communication;Databases;Diagnostic;Disease;Disease Progression;Environment;exhaustion;Experimental Models;extracellular;Functional disorder;Growth;Growth Factor;Human;Immune;immune checkpoint;Immune Evasion;Immune response;Immunology;improved;in vivo;Induction of Apoptosis;insight;Intervention;Ligands;LRRC32 gene;Lung;lung cancer cell;Lung Neoplasms;Malignant neoplasm of lung;Malignant neoplasm of ovary;Malignant Neoplasms;Mediating;Megakaryocytes;Messenger RNA;Metastatic Neoplasm to the Lung;Methods;mortality;mouse model;Mus;Neoplasm Metastasis;neoplastic cell;novel;novel strategies;particle;Patients;Phosphoric Monoester Hydrolases;Platelet Count measurement;prevent;programmed cell death protein 1;Protein Dephosphorylation;Protein Kinase;Protein phosphatase;Protein Phosphatase-1 alpha;Proteins;Proteome;Proteomics;Research Personnel;RNA;Role;screening;Serine;Signal Pathway;Signal Transduction;Site;Source;Stream;Supporting Cell;Survival Rate;T-Lymphocyte;Testing;The Cancer Genome Atlas;Therapeutic;Threonine;thrombocytosis;Transcription Coactivator;Transforming Growth Factor beta;Transforming Growth Factor beta Receptors;Treatment Efficacy;tumor;Tumor Burden;tumor microenvironment;tumor progression;United States;Work

PROJECT_TITLE: Platelet Serine/Threonine Phosphatases in Cancer Pathophysiology

STUDY_SECTION: HT

STUDY_SECTION_NAME: Hemostasis and Thrombosis Study Section.  Committee was terminated on 11/30/2020. [HT]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Drug Abuse (NIDA only);Electronic Nicotine Delivery Systems;Pediatric;Prevention;Substance Misuse;Tobacco

PHR: PROJECT NARRATIVE Effective, school-based interventions are urgently needed to protect adolescents from initiating or continuing use of electronic vaping products (EVPs). This study leverages a state-supported prevention initiative to test the effectiveness of a promising intervention that trains 8th -9th grade student peer leaders to deliver school- wide vaping prevention campaigns with ongoing adult mentoring. If study hypotheses are supported, the study will provide the first evidence of a school-based preventive intervention that reduces adolescent vaping behaviors, as well as insight into how peer communications can be harnessed to prevent vaping.

PI_NAMEs: WYMAN, PETER A (contact)

PROGRAM_OFFICER_NAME: ROMBERG, ALEXA RUTH

PROJECT_TERMS: addiction;Address;Adherence;Adolescent;Adult;Alcohol abuse;Behavior;cohort;Collaborations;Communication;Communities;Community based prevention;comparison control;cost;Data;design;Drug usage;Education;educational atmosphere;Educational Intervention;Effectiveness;effectiveness testing;efficacy research;efficacy testing;efficacy/implementation trial;eighth grade;electronic vape;Elements;Enrollment;epidemiologic data;Esthesia;experience;experimental study;falls;Friends;Funding;Future;Goals;Health;high risk;high risk population;High School Student;Hybrids;implementation barriers;implementation facilitators;implementation strategy;improved;informant;insight;Intervention;Interview;junior high school;Learning Skill;Logic;Mediating;Mediation;Mediator;Mental Health;Mentors;Modeling;Moods;New York;nicotine exposure;ninth grade;peer;Peer Group;peer networks;Perception;personal narratives;prevent;Prevention;Prevention program;Prevention trial;preventive intervention;Problem behavior;programs;Randomized;recruit;Reporting;Research;Research Personnel;Respiratory Signs and Symptoms;Risk;Schools;Science;Services;sex;Site;skills;social;social influence;Statistical Data Interpretation;Structure;Students;Substance abuse problem;Surgeon;tenth grade;Testing;Time;Tobacco use;Training;vaping;vaping nicotine;Waiting Lists;Youth

PROJECT_TITLE: Testing Peer-led Network Intervention to Prevent Adolescent Vaping


ADMINISTERING_IC: EB

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: COLLEGE PARK

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

PHR: PROJECT NARRATIVE Current techniques for peripheral artery disease (PAD) diagnosis are not suited to low-cost, high-throughput, and accurate screening and surveillance. Modern deep learning (DL) and arterial pulse waveform analysis can be combined to enhance the convenience and efficacy of PAD diagnosis but at the cost of unrealistically large datasets. In this project, we will study the feasibility of DL-enabled pulse waveform analysis for PAD diagnosis by developing a novel computational method to efficiently train DL algorithms using scare datasets.

PI_NAMEs: HAHN, JIN-OH  (contact)

PROGRAM_OFFICER_NAME: PEREIRA DE SA, RUI CARLOS

PROJECT_TERMS: Address;adversarial learning;Affect;Aging;algorithm training;Anatomy;Ankle;arm;arterial stiffness;Arteries;Awareness;Biomechanics;Blood Pressure;Cardiovascular Diseases;Characteristics;Classification;Clinical;Computing Methodologies;cost;Data Set;deep learning;deep learning algorithm;Detection;Deterioration;Diagnosis;Disadvantaged;disease diagnosis;Disease Progression;efficacy evaluation;Equipment;Feasibility Studies;feature selection;follow-up;Fostering;Height;Human;Imaging Techniques;in silico;in vivo;indexing;Label;large datasets;Learning;Limb structure;mathematical model;Measures;Methods;Modernization;Morbidity - disease rate;Morphology;mortality risk;novel;Patients;Performance;Peripheral arterial disease;Physiologic pulse;Primary Care;Procedures;Resort;Resources;Sample Size;screening;Severities;Signal Transduction;Site;success;Techniques;Time;Training;Trees;United States;Vascular Diseases;virtual patient

PROJECT_TITLE: Deep Learning-Enabled Arterial Pulse Waveform Analysis Approach to Peripheral Artery Disease Diagnosis

STUDY_SECTION: CDMA

STUDY_SECTION_NAME: Clinical Data Management and Analysis Study Section[CDMA]


ORG_CITY: WEST HAVEN

ORG_NAME: VA CONNECTICUT HEALTHCARE SYSTEM

ORG_STATE: CT

PHR: Medication treatment of Opioid Use Disorder (MOUD) saves lives and is increasingly delivered virtually. However, toxicology testing, a major component of MOUD care, is either not completed as part of virtual care or requires in-person urine testing, which is inconvenient and stigmatizing. A process of Virtual Point-of-Care Toxicology Testing will increase convenience, facilitate patient-centered care, and decrease stigma, improving MOUD utilization and patient outcomes. This research will design a Virtual Point-of-Care Toxicology Testing Process, using feedback from VA-wide leaders, providers, and patients. A pilot trial will evaluate the feasibility, acceptability, and proximal effects of the process by analyzing provider and patient testing uptake, qualitative feedback, and health service use. The process will be packaged into a toolkit for VA-wide dissemination, as well as testing in a future multisite, randomized effectiveness trial.

PI_NAMEs: HERMES, ERIC  (contact)

PROJECT_TERMS: Abstinence;Acceleration;addiction;Address;American;arm;Behavior Therapy;Buprenorphine;Caring;Characteristics;Clinical;Computerized Medical Record;Connecticut;Consolidated Framework for Implementation Research;contingency management;Data;Data Collection;design;Diagnostic Reagent Kits;Documentation;drug of abuse;Drug Prescriptions;drug testing;Drug usage;Educational Materials;effectiveness evaluation;Feedback;Future;Goals;health service use;Healthcare Systems;Hybrids;improved;innovation;Institution;Intervention;Interview;Laboratories;Leadership;Life;Liquid substance;Massachusetts;Medical Records;medication for opioid use disorder;medication-assisted treatment;Medicine;meetings;Methodology;Methods;Modality;multi-site trial;novel;Opioid;opioid use disorder;Oral;Outcome;Outpatients;pandemic disease;Patient Schedules;Patient-Centered Care;Patient-Focused Outcomes;Patients;Persons;Pharmaceutical Preparations;Phase;pilot trial;point of care;point of care testing;Policies;Privacy;Procedures;Process;Provider;Publishing;Randomized;randomized effectiveness trial;randomized trial;randomized, clinical trials;Reading;Recommendation;Regulation;Research;Resources;Saliva;Sampling;scale up;Secure;Self Administration;self testing;Services;Site;social stigma;Societies;Specific qualifier value;Stigmatization;Structure;substance use;Substance Use Disorder;Telephone;Test Result;Testing;testing uptake;Time;Toxicology;Travel;trend;United States Department of Veterans Affairs;uptake;Urine;usability;user centered design;Veterans;virtual;virtual delivery;virtual healthcare;Visit;Visualization

PROJECT_TITLE: Virtual MOUD Treatment: Virtual Point-of-Care Toxicology Testing to Accompany Virtual Medication Assisted Treatment for Opioid Use Disorder

STUDY_SECTION_NAME: Special Emphasis Panel[HSR9]


ORG_CITY: PALO ALTO

ORG_NAME: VETERANS ADMIN PALO ALTO HEALTH CARE SYS

PHR: Obesity is a major cause of preventable diseases and deaths in the United States. Over 40% of Veterans using Veterans Health Administration (VA) primary care have obesity. However, less than 8% of eligible Veterans use VA’s effective weight management programs. EMBER – a novel, motivational, self-help tool – could increase Veterans’ engagement in weight management programs. Greater Veteran engagement in these programs would have a large impact on Veterans’ health, including weight loss and associated improvements in physical health, function, and quality of life. EMBER’s flexible design will facilitate the incorporation of new weight management programs as they are introduced as VA services. In addition, it may be of particular value to Veterans of color, given their high obesity rates. Finally, EMBER is patient-centered, which will facilitate Veterans’ engagement in treatments aligned with their needs and interests, while ensuring appropriate use of VA resources.

PI_NAMEs: BRELAND, JESSICA YELENA (contact)

PROJECT_TERMS: Address;Affect;arm;Behavior;Behavioral;behavioral health;Belief;Body Weight decreased;Cardiovascular Diseases;Cessation of life;Color;comorbidity;Complications of Diabetes Mellitus;cost;Data;design;Diabetes Mellitus;digital;Disease;disorder prevention;Dissemination and Implementation;Effectiveness;effectiveness/implementation trial;Eligibility Determination;Ensure;Equity;Exercise;flexibility;follow-up;Food Services;Goals;Health;health equity;Health Promotion;health service use;Health Services Accessibility;Health Services Administration;Heart Diseases;high risk;high risk population;hybrid type 1 design;hybrid type 1 trial;hybrid type 2 trial;Hybrids;implementation outcomes;implementation science;implementation strategy;improved;innovation;interest;Intervention;Interview;K-Series Research Career Programs;Letters;Malignant Neoplasms;Methodology;Methods;Modeling;Morbidity - disease rate;mortality;Motivation;motivational enhancement therapy;novel;nutrition;obese patients;Obesity;obesity risk;Organization and Administration;Outcome;Pain management;Paper;Participant;patient oriented;Patient Self-Report;Patient-Centered Care;Patients;people of color;Persons;Physical activity;physical conditioning;Pilot Projects;Population;population health;Primary Care;primary care patient;primary care practice;primary outcome;programs;Quality of life;Randomized;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Research;Research Design;Research Priority;Risk;Science;secondary outcome;Self Direction;Self Efficacy;self help;Series;Services;severe COVID-19;Site;smoking cessation;System;Testing;therapy design;Time;tool;Touch sensation;Translating;United States;United States Health Resources Administration;Veterans;Veterans Health Administration;virtual healthcare;Weight;Weight Gain;Weight maintenance regimen;Woman;Work

PROJECT_TITLE: The EMBER Trial for Weight Management Engagement

STUDY_SECTION_NAME: HSR-2 Behavioral, Social, and Cultural Determinants of Health and Care[HSR2]


ORG_CITY: CHARLESTON

ORG_NAME: RALPH H JOHNSON VA MEDICAL CENTER

ORG_STATE: SC

PHR: Tobacco and cannabis are commonly used together in the Veteran population. Co-use of cannabis and tobacco has significant negative psychiatric and psychosocial consequences. This study is a 12-week, randomized, placebo-controlled, parallel group trial to evaluate the efficacy of varenicline for reduction of cannabis and tobacco use among Veterans.

PI_NAMEs: MCRAE-CLARK, AIMEE L (contact)

PROJECT_TERMS: Agonist;alcohol abuse therapy;alcohol use disorder;Cannabis;clinical effect;cognitive enhancement;cognitive function;comorbidity;Data;Development;efficacy evaluation;improved;Individual;marijuana use;marijuana use disorder;Mediating;mesolimbic system;military veteran;Morbidity - disease rate;Outcome;Pharmaceutical Preparations;Pharmacotherapy;Placebo Control;placebo controlled trial;Placebos;Prevalence;primary outcome;psychosocial;Randomized;receptor;reduce tobacco use;Research;restoration;Tobacco;tobacco abstinence;Tobacco use;Tobacco Use Disorder;varenicline;Veterans

PROJECT_TITLE: Varenicline for Comorbid Tobacco and Cannnabis Use in Veterans


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: GAINESVILLE

ORG_NAME: VETERANS HEALTH ADMINISTRATION

ORG_STATE: FL

PHR: As many as 7 out of 10 Veterans have high blood pressure while in the hospital. Many doctors and nurses treat this high blood pressure with quick-acting blood pressure medications, even if the patient has no symptoms. Currently, there are no guidelines to say that this is the right thing to do. Also, recent studies show that treating high blood pressure in the hospital with quick-acting medicines may lead to very low blood pressure, kidney failure, stroke, falls and other harms, especially in older patients with other chronic illnesses like Veterans. With this study, we will find out how often doctors treat high blood pressure in VA hospitals with quick-acting medicines and talk to doctors and nurses about what makes them decide to treat. We will use this information to, in later projects, develop a tool to help doctors and nurses use these medications the right way. We hope that our research will, in the long term, improve the quality, safety and cost of hospital care for our Veterans.

PI_NAMEs: CANALES, MUNA T (contact)

PROJECT_TERMS: Acute;Acute Renal Failure with Renal Papillary Necrosis;Address;Admission activity;Adverse effects;Adverse event;Algorithms;Blood Pressure;blood pressure elevation;blood pressure medication;care costs;Caring;Chronic Disease;Clinical;Clinical Data;Cluster randomized trial;Code;cohort;comorbidity;Complement;Consensus;cost;cost outcomes;Costs and Benefits;Data;Data Sources;data warehouse;Databases;design;Development;Diagnosis;Discipline of Nursing;Drops;Educational Status;Electronic Health Record;Elements;Event;experience;falls;Future;Goals;Guidelines;health care service utilization;Healthcare;Healthcare Systems;High Prevalence;high risk;hospital care;Hospital Costs;Hospital safety;Hospitalization;Hospitals;human old age (65+);Hypertension;Hypotension;implementation intervention;improved;Individual;Informatics;innovation;Inpatients;Institution;Intervention;Interview;Intravenous;Ischemia;Kidney Failure;Knowledge;Literature;Measures;Medicine;Methodology;Methods;Motivation;Nature;novel;Nurses;Nursing Staff;older adult;older patient;overtreatment;Patient-Focused Outcomes;Patients;Pattern;Pharmaceutical Preparations;pharmacy benefit;Pilot Projects;Population;Predictive Factor;Predisposition;Prevalence;Process;Provider;Qualitative Research;Renal function;Research;Research Technics;Resource Informatics;Resources;Safety;safety outcomes;sociodemographic factors;sociodemographics;Stroke;Sum;Surveys;Symptoms;System;tertiary care;Testing;therapy design;tool;Variant;Vascular System;Veterans;Work;Workload

PROJECT_TITLE: PRN Blood Pressure Medication Use in VA Hospitals: A Mixed Methods Approach

STUDY_SECTION_NAME: HSR-1 Health Care and Clinical Management[HSR1]


ORG_NAME: MICHAEL E DEBAKEY VA MEDICAL CENTER

PHR: Despite primary hyperparathyroidism being a common endocrine disease, which can lead to significant preventable complications (including kidney stones, severe bone weakening and fractures, depression, gastrointestinal problems, renal dysfunction, body aches and other symptoms, all of which decrease the quality of life), previous research has shown severe under-detection of the disease in the VA healthcare system and undertreatment of it with the recommended surgery. The proposed study will explore the underlying reasons for these findings, and it will harness the medical providers’ perceptions on the management of the disease in their practice, as well as their input on proposed interventions. These findings will lead to a robust, data-based design of corrective interventions that can effectively bridge the observed gap in care and increase the safety and value of the VA healthcare system.

PI_NAMEs: MAKRIS, KONSTANTINOS  (contact)

PROJECT_TERMS: Ache;Address;Affect;American;Area;Attitude;bone;Cardiovascular system;Caring;Cessation of life;Cognition Disorders;Data;data warehouse;Databases;design;Detection;Diagnosis;Diagnostic;diagnostic tool;Disease;Disease Management;Early Diagnosis;effective intervention;Electronic Health Record;Endocrine;Endocrine System Diseases;Evaluation;Event;evidence base;evidence based guidelines;Fracture;Functional disorder;Future;gastrointestinal;Goals;Guideline Adherence;Guidelines;Health Services Research;Healthcare Systems;high risk;Hip Fractures;Hypercalcemia;Hyperparathyroidism;Impairment;improved;Incidence;Individual;Informatics;Information Systems;innovation;Institution;Intervention;Interview;Investigation;Kidney Calculi;kidney dysfunction;Knowledge;Laboratories;Link;Medical;Medical Records;men;Mental Depression;Methodology;Methods;Modeling;Musculoskeletal Pain;Nephrolithiasis;neuropsychiatric disorder;Newly Diagnosed;novel strategies;Observational Study;operation;Operative Surgical Procedures;Osteoporosis;Parathyroidectomy;Pathological fracture;Patients;Perception;Performance;Persons;Pilot Projects;premature;Provider;PTH gene;Public Health Informatics;Quality of life;Recommendation;Research;Risk;Risk Factors;Safety;Short-Term Memory;Structure;success;Surgeon;Surgical Management;Surgical Pathology;Symptoms;System;Testing;Time;treatment comparison;United States;United States Department of Veterans Affairs;Veterans;Veterans Health Administration;Woman;Work

PROJECT_TITLE: Understanding Reasons for Underdiagnosis and Undertreatment of Primary Hyperparathyroidism in the VA


NIH_SPENDING_CATS: Biotechnology;Immunization;Infectious Diseases;Malaria;Malaria Vaccine;Orphan Drug;Pediatric;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases

ORG_CITY: TAMPA

ORG_NAME: UNIVERSITY OF SOUTH FLORIDA

PHR: PROJECT NARRATIVE Malaria is the deadliest parasitic disease on the planet. The search for a vaccine against malaria caused by Plasmodium falciparum has lasted for more than 100 years, yet no vaccine with acceptable efficacy in the field for malaria has so far been developed. In this project, we will use a rodent malaria model to optimize the formulation of a CDPK5 based vaccine using fusion antigen CDPK5-MSPs in combination with GARP.

PI_NAMEs: RAJ, DIPAK KUMAR (contact)

PROGRAM_OFFICER_NAME: MO, ANNIE X  Y

PROJECT_TERMS: 2 year old;5 year old;Achievement;Adjuvant;Adjuvant Study;Affect;Africa;Africa South of the Sahara;Alhydrogel;Animals;Antibodies;antibody test;Antibody titer measurement;Antigens;Aotus primate;Area;asexual;B-Cell Development;B-Lymphocytes;BALB/cJ Mouse;Biological Assay;Birth;Blocking Antibodies;Blood;calcium-dependent protein kinase;cDNA Library;cell mediated immune response;Cells;Cerebral Malaria;Cessation of life;Child;Childhood;Chimeric Proteins;Clinical;cohort;comparison control;Complementary DNA;Country;Data;Death Rate;design;Development;Disease;disorder control;Dose;Encapsulated;Enzyme-Linked Immunosorbent Assay;epidemiologic data;Erythrocytes;Evaluation;Falciparum Malaria;Formulation;Future;Generations;Genes;Genetic Transcription;Glutamic Acid;Growth;Growth and Development function;Helper-Inducer T-Lymphocyte;Hemoglobin concentration result;Human;Immune system;Immunize;Immunodominant Epitopes;In Vitro;in vitro Assay;Individual;Infection;Invaded;Laboratories;Lead;Legal patent;Length;Libraries;Life Cycle Stages;Ligands;Lipids;Malaria;Malaria Vaccines;Measures;Memory B-Lymphocyte;Messenger RNA;Methods;Modeling;Monkeys;Morbidity - disease rate;mortality;mouse model;Mus;nonhuman primate;novel;novel vaccines;Orthologous Gene;Parasitemia;Parasites;Parasitic Diseases;Pathway interactions;Phage Display;Phase;Phase I Clinical Trials;Planets;Plants;Plasma;Plasmodium falciparum;polyclonal antibody;Population;Predisposition;primary outcome;Primates;Process;programs;Proteins;Proteome;Publications;Publishing;Regulatory T-Lymphocyte;Research;Resistance;response;Rodent;Rupture;Science;screening;secondary outcome;Side;Site;success;Surface;synergism;System;Tanzania;TiterMax;Vaccinated;Vaccination;vaccine candidate;vaccine discovery;vaccine efficacy;vaccine evaluation;vaccine trial;Vaccines;Work

PROJECT_TITLE: Multi-target blood stage vaccine against Plasmodium falciparum

STUDY_SECTION: VMD

STUDY_SECTION_NAME: Vaccines Against Microbial Diseases Study Section[VMD]


ADMINISTERING_IC: DC

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Bioengineering;Nanotechnology

ORG_CITY: SAINT LOUIS

ORG_NAME: SAINT LOUIS UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE This project will quantify the effects of pharmacologic treatments on the regulation of vocal fold permeability. This novel treatment concept has implications on the management of vocal fold disease. These pre-clinical studies will provide indications for use, safety, and the demonstration of therapeutic efficacy prior to human trials.

PI_NAMEs: ROUSSEAU, BERNARD  (contact)

PROGRAM_OFFICER_NAME: KOPF, LISA MARIE

PROJECT_TERMS: Address;Adult;aerosolized;Allergic rhinitis;Anti-Inflammatory Agents;Asthma;Biocompatible Materials;Biological Availability;Cells;Censuses;Chronic Obstructive Pulmonary Disease;comparative;cost;Data;delivery vehicle;density;Diabetes Mellitus;Direct Costs;Disease;Dose;Down-Regulation;Drug Delivery Systems;Drug vehicle;Dysphonia;Epithelium;experience;experimental study;Filler;Functional disorder;Genes;Genetic Transcription;Glucocorticoids;Goals;Human;Human body;improved;In Vitro;in vivo;insight;Investigation;Laboratories;Lateral;Mediating;Methylprednisolone;Molecular;nanoparticle;nanoparticle delivery;novel;occludin;Pathway interactions;Patient Care;Permeability;Pharmaceutical Preparations;pharmacologic;Pharmacological Treatment;Phase;Population;preclinical study;Prevalence;programs;Protein Biosynthesis;Proteins;Public Health;Regulation;Research;Resistance;RNA;Role;Safety;Series;small molecule;steroid hormone;Testing;Therapeutic;Therapeutic Equivalency;Tight Junctions;Tissues;Translations;Treatment Cost;Treatment Efficacy;United States;vocal cord;Voice Disorders;Wages

PROJECT_TITLE: Pharmacological Approaches for Transepithelial Delivery of Therapeutics to the Vocal Folds

STUDY_SECTION: MFSR

STUDY_SECTION_NAME: Motor Function, Speech and Rehabilitation Study Section[MFSR]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Clinical Research;Mental Health;Neurosciences

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Language comprehension is necessary for effective human communication and social function. Therefore, when it breaks down, as it does in many neurodevelopmental and acquired disorders, such as schizophrenia and autism spectrum disorders, the consequences can be devastating. This grant uses multimodal neuroimaging techniques to ask fundamental questions about the neural and computational mechanisms underlying language comprehension in healthy adults, laying essential groundwork for the development of theoretically motivated prevention and remediation strategies to target specific communication deficits across multiple neurodevelopmental and neuropsychiatric disorders.

PI_NAMEs: KUPERBERG, GINA R (contact)

PROGRAM_OFFICER_NAME: SALO, VIRGINIA CHARLOTTE

PROJECT_TERMS: Adult;Anterior;Appearance;autism spectrum disorder;Belief;Brain;Code;cognitive function;Communication;Communication Disability;Communicative Dysfunctions;Computer Models;Computer Simulation;Cues;Development;Disease;Dyslexia;Electroencephalography;Environment;Event;Event-Related Potentials;experimental study;Failure;Feedback;flexibility;Foundations;Frequencies;frontal lobe;Functional Magnetic Resonance Imaging;Grant;Human;Image;Impairment;Inferior;insight;Language;language comprehension;Language Disorders;language processing;Left;lexical;Linguistics;Link;Location;Magnetoencephalography;Methods;Modeling;multimodal neuroimaging;Neighborhoods;neural;neural patterning;Neurobiology;Neurocognitive;Neurodevelopmental Disorder;neuroimaging;neuropsychiatric disorder;Orthography;Phase;Prefrontal Cortex;Prevention;Reading Disabilities;remediation;Research;response;Schizophrenia;semantic processing;Semantics;Sensory;sensory input;Series;social deficits;Social Functioning;spatiotemporal;Stimulus;support network;Techniques;Temporal Lobe;Testing;theories;tool;treatment strategy

PROJECT_TITLE: The neural basis of language comprehension: Insights from spatiotemporal imaging

STUDY_SECTION: LCOM

STUDY_SECTION_NAME: Language and Communication Study Section[LCOM]


FUNDING_MECHANISM: OTHERS

ORG_NAME: PHILADELPHIA VA MEDICAL CENTER

PHR: Rates of sexually transmitted infection (STI), especially gonorrhea and chlamydia, have increased dramatically over the past decade. However, screening remains suboptimal. Women are more vulnerable to the effects of STIs than men and are disproportionately affected by STIs. Several factors put women Veterans at higher risk for STIs as compared with both non-Veteran women and male Veterans. Few studies have examined the epidemiology of STIs in women Veterans and none has assessed health system responses to STIs or examined patterns of STI screening among women Veterans. To establish an appropriate and effective prevention plan, it is necessary to understand the current landscape of STI screening in VA. This study will assess and explore practice-, provider-, and patient-level correlates and barriers/facilitators to gonorrhea and chlamydia screening in VA women’s health. This information will be used to develop and pilot a clinical decision support tool to improve gonorrhea and chlamydia screening for women Veterans.

PI_NAMEs: KEDDEM, SHIMRIT  (contact)

PROJECT_TERMS: active duty;adverse outcome;Affect;Age;Area;Awareness;Behavior;Benchmarking;Big Data;career;career development;Caring;Centers for Disease Control and Prevention (U.S.);Characteristics;Chlamydia;Chlamydia Infections;chronic pelvic pain;clinical decision support;Clinical Services;cost effective intervention;Counseling;COVID-19;Data;Data Analyses;Detection;Development;Diagnosis;disorder prevention;Documentation;Early Diagnosis;Ectopic Pregnancy;effectiveness/implementation trial;Electronic Health Record;Eligibility Determination;Epidemiology;ethnic minority population;Evaluation;experience;Exposure to;Feedback;Foundations;Future;General Population;Gonorrhea;Guidelines;health assessment;Health Promotion;Health Services Research;Health system;Healthcare;Hepatitis;high risk;HIV;HIV Infections;Hysterectomy;improved;Infection;infection management;infection rate;Infertility;Informatics;innovation;Intervention;Interview;intimate partner violence;Investigator-Initiated Research;K-Series Research Career Programs;male;men;Methodology;Methods;Military Personnel;military women;multilevel analysis;Outcome;Patient Self-Report;patient-level barriers;Patients;Pattern;Pelvic Inflammatory Disease;Personal Satisfaction;pilot test;Play;post-traumatic stress;Predisposition;prevent;Prevention;Primary Care;primary care clinic;Provider;racial minority;Recommendation;Recording of previous events;Research;research and development;Research Personnel;Research Proposals;response;Risk;Risk Factors;Role;routine screening;screening;screening guidelines;sexual and reproductive health;sexual trauma;sexual violence;sexually active;Sexually Transmitted Diseases;Site;Specific qualifier value;substance use;support tools;Symptoms;Testing;therapy design;tool;Training;trend;United States Preventative Services Task Force;Unmarried;uptake;usability;user centered design;Veterans;Woman;women patients;Women's Health;Women's Health Services;women's reproductive health;Work

PROJECT_TITLE: Assessing Trends in STI Screening among Women Veterans in the VHA

STUDY_SECTION_NAME: Research Career Scientist[MRA0]


ORG_CITY: PORTLAND

ORG_NAME: PORTLAND VA MEDICAL CENTER

ORG_STATE: OR

PHR: The Veterans Benefits Administration (VBA) reports that, in Fiscal Year 2018, tinnitus was the most prevalent service-connected (SC) disability for all compensation recipients (1,971,201 Veterans), as well as the most prevalent SC disability among new compensation recipients (157,152 Veterans). Treatments claiming to reduce the sound of tinnitus show promise, but they need reliable measures of tinnitus features such as its loudness, pitch, and maskability. The previous study found age-specific standard ranges for these measurements using our computer-automated Tinnitus Evaluation System (TES). The new study will expand the previous study to: represent all age groups equally, obtain test-retest data over an extended period of time, test a pre-test training program for tinnitus pitch matching, and update the TES for ease of use in VA Audiology clinics. This project will result in more complete standards of tinnitus measurements and state-of-the-art equipment that will promote valid and reliable measurement of how tinnitus sounds to Veterans.

PI_NAMEs: FOLMER, ROBERT  (contact)

PROJECT_TITLE: Validation and Expansion of Established Norms for Measures of Tinnitus Perception

STUDY_SECTION_NAME: Sensory Systems & Communication Disorders[RRD3]


NIH_SPENDING_CATS: Childhood Injury;Disability Research;Neurosciences;Pediatric;Physical Injury - Accidents and Adverse Effects;Prevention;Spinal Cord Injury;Traumatic Head and Spine Injury;Unintentional Childhood Injury

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

PHR: The proposed research will significantly contribute to our understanding of brachial plexus strains and forces that lead to spinal cord injury and the resulting injury mechanisms. Also, data obtained from acute injury biomarkers and computational models can guide the development of clinical tools that aid in treatment and prevention of spinal cord injury due to brachial plexus stretch. Overall, the proposed study is directly aligned with the NIH high priority research areas by offering data that can be used to develop prevention strategies for neonatal brachial plexus palsy and associated spinal cord injury occurrence and their outcomes while advancing the science of neonatal care.

PI_NAMEs: SINGH, ANITA  (contact)

PROGRAM_OFFICER_NAME: CHAKHTOURA, NAHIDA ABDO

PROJECT_TERMS: 3-Dimensional;Acute;Animals;Area;avulsion injury;Biochemical;biochemical model;Biological Assay;Biological Markers;Biomechanics;Brachial plexus structure;Cadaver;Cerebrospinal Fluid;Childbirth;Clinical;clinical development;clinical diagnostics;clinical training;clinically relevant;combinatorial;Complex;Complication;Computer Models;Data;delivery complications;Development;Devices;Diagnosis;Diagnostic;diagnostic tool;Discipline of obstetrics;early detection biomarkers;Early Diagnosis;Early Intervention;Early treatment;Electrophysiology (science);Elements;Event;Failure;fetal;Fetus;force sensor;Functional disorder;functional loss;functional status;Gamma Motor Neurons;Goals;Head and neck structure;Hemorrhage;Histologic;Human;in silico;In Situ;in vivo;Inflammatory Response;Injury;injury prevention;innovation;insight;Intervention;Knowledge;Lateral;Lead;Lifelong disability;long-term sequelae;Maps;Modeling;Molecular;molecular marker;Morphology;motor neuron degeneration;Motor Neurons;Neonatal;neonatal care;neuroinflammation;neuronal excitability;Neurons;next generation;novel;Outcome;Paralysed;Pathologic;Pathology;Pelvis;porcine model;predictive modeling;predictive tools;pressure;prevent;Prevention;Prevention strategy;primipara;Property;Proteomics;Publishing;Reporting;Research;Research Priority;response;Risk;Risk Factors;risk prediction;Science;Serum;severe injury;simulation;Spinal;Spinal Cord;Spinal cord injury;Stretching;Testing;Therapeutic;Tissues;tool;Training;transmission process;treatment strategy;United States National Institutes of Health;Visualization software;Work

PROJECT_TITLE: Investigating Injury Tolerance and Mechanisms of Neonatal Brachial Plexus Palsy and Associated Injuries

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Health Services;Mental Health;Pediatric;Prevention;Telehealth

ORG_CITY: JACKSONVILLE

ORG_NAME: NEMOURS CHILDREN'S CLINIC

PHR: PROJECT NARRATIVE Sixty percent of parents of young children with type 1 diabetes report at least moderate levels of hypoglycemia fear, which is associated with poor quality of life and compensatory behaviors that raise children’s blood glucose levels and risk for diabetes-related complications. This study is relevant to public health because it proposes to conduct a randomized clinical trial comparing an innovative, video-based telemedicine intervention to reduce parental hypoglycemia fear to a video-based telemedicine attention control intervention in families of young children with type 1 diabetes. The long-term goal of this line of research is to develop and disseminate effective and scalable treatments for families of young children with type 1 diabetes that help children to achieve and maintain optimal glycemic control, thereby improving health outcomes and reducing their risk of diabetes-related complications.

PI_NAMEs: PATTON, SUSANA R (contact)

PROGRAM_OFFICER_NAME: THORNTON, PAMELA L

PROJECT_TERMS: Accelerometer;Address;Adherence;Adolescent and Young Adult;Adult;Aftercare;Age;analog;Attention;attentional control;avoidance behavior;Behavior;Behavioral;Blood Glucose;Blood Vessels;Child;Child Health;Child Rearing;Childhood;Cognitive Therapy;Complications of Diabetes Mellitus;Continuous Glucose Monitor;Dangerousness;Data;Development;diabetes education;diabetes risk;diabetes self-management;Educational process of instructing;effective therapy;efficacy testing;emotional distress;Event;Evidence based intervention;experience;Family;follow up assessment;follow-up;Foundations;Fright;Future;Glucose;glycemic control;Glycosylated hemoglobin A;Goals;Health;Home;Hypoglycemia;Impairment;improved;Individual;Informed Consent;innovation;Insulin;Insulin Infusion Systems;Insulin-Dependent Diabetes Mellitus;Intervention;Learning;Literature;Maintenance;Measures;Metabolic Control;National Institute of Diabetes and Digestive and Kidney Diseases;Outcome;Outcome Measure;parenting intervention;Parents;Patients;Persons;programs;Public Health;Quality of life;Randomized;randomized, clinical trials;recruit;Reporting;Research;Risk;satisfaction;School-Age Population;Seizures;sex;Specific Phobia;Stratification;Stress;Surveys;Symptoms;Technology;Telemedicine;Time;treatment comparison;treatment effect;trial comparing;Work;Youth

PROJECT_TITLE: Home Video-Based Telemedicine to Reduce Hypoglycemia Fear in Parents of Young Children

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


NIH_SPENDING_CATS: Clinical Research;Digestive Diseases;Kidney Disease;Liver Disease

ORG_CITY: NEW YORK

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Major liver surgery is a very common procedure and liver ischemia and reperfusion injury is a major clinical problem. Many patients suffer complications from liver surgery including acute kidney injury, intestinal barrier disfunction and systemic inflammatory response syndrome leading to sepsis. In this translational proposal, we will determine whether 1) cynomolgus monkey and human liver IR injury cause small intestinal Paneth cells to dysregulate and release IL-17A and 2) IL-17A neutralizing antibody attenuates hepatic as well as acute kidney injury after liver IR in cynomolgus monkeys.

PI_NAMEs: GRIESEMER, ADAM DAVID;LEE, H. THOMAS  (contact)

PROGRAM_OFFICER_NAME: SHERKER, AVERELL H

PROJECT_TERMS: Acute Renal Failure with Renal Papillary Necrosis;Ankylosing spondylitis;Apoptosis;Attenuated;Autoimmune Diseases;Cell Degranulation;Clinical;clinical translation;clinically significant;Coupled;cytokine;Data;Excision;Extrahepatic;Functional disorder;Genetic;Goals;gut inflammation;Hepatic;Human;IL17 gene;In Vitro;in vivo;Incidence;Inflammation;Inflammatory;Injury to Kidney;intestinal barrier;intestinal crypt;intestinal injury;Intestines;intrahepatic;Ischemia;ischemic injury;Kidney;Liver;liver injury;liver ischemia;liver transplantation;lung injury;Macaca fascicularis;Mediating;Modeling;Monkeys;multiorgan injury;Mus;Necrosis;neutralizing antibody;nonhuman primate;novel;Operative Surgical Procedures;Organ;organ injury;Paneth Cells;Patients;Portal vein structure;Postoperative Period;prevent;Procedures;Psoriasis;Psoriatic Arthritis;Reconstructive Surgical Procedures;Reperfusion Injury;Reperfusion Therapy;Sepsis;Small Intestines;Source;Systemic Inflammatory Response Syndrome;targeted treatment;Testing;therapy development;translational approach;translational study

PROJECT_TITLE: Paneth cells-derived IL-17A and liver ischemia reperfusion injury

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


ORG_CITY: NORTH LITTLE ROCK

ORG_NAME: CENTRAL ARKANSAS VETERANS HLTHCARE SYS

ORG_STATE: AR

PHR: This VHA Career Development Award will ensure Dr. Hayes’s expertise in translating knowledge gained from electronic health record (EHR) data and predictive analytics (e.g., predicting the future probability of an outcome for individuals) into interventions that increase Veterans’ retention in medication treatment for opioid use disorder (MOUD; e.g., buprenorphine). His specific training areas span the spectrum of learning advanced methods for working with EHR data, how to develop computer-based tools, and how to test the effectiveness of new interventions. Dr. Hayes will apply this new knowledge to (a) develop a mathematical model that will continuously assess Veterans’ risk of discontinuing MOUD, (b) create a computer-delivered clinical tool that provides clinicians with information (i.e., patient-specific likelihood risk, patient-specific risk factors for discontinuing MOUD, and treatment guidelines, when indicated) on Veterans’ risk of discontinuing MOUD, and (c) test the feasibility/acceptability of the clinical tool among VHA providers who are prescribing buprenorphine.

PI_NAMEs: HAYES, COREY J (contact)

PROJECT_TERMS: acceptability and feasibility;Address;Area;arm;Artificial Intelligence;artificial intelligence method;Automobile Driving;Big Data;Big Data Methods;big-data science;Buprenorphine;Businesses;care systems;career;Caring;Clinical;clinical decision support;comorbidity;Computers;Counseling;Data;Data Analytics;Data Science;data warehouse;design;Diagnosis;Discrimination;Dose;Drug usage;Effectiveness;effectiveness evaluation;effectiveness testing;Electronic Health Record;Enrollment;Ensure;experience;Feasibility Studies;feasibility testing;feedforward neural network;Focus Groups;follow-up;Frequencies;Future;Guidelines;Health Services Accessibility;Healthcare;high risk;Homogeneously Staining Region;Hybrids;illicit drug use;implementation science;improved;improved outcome;Individual;Informatics;innovation;Intelligence;interest;Intervention;K-Series Research Career Programs;Knowledge;Learning;Logistic Regressions;machine learning method;mathematical model;Measures;medical specialties;medication for opioid use disorder;Mental Health;Methadone;Methodology;Methods;military veteran;Modeling;modifiable risk;Monitor;mortality;Naltrexone;neural network;operation;Opioid;opioid overdose;opioid use disorder;Outcome;Overdose;overdose risk;Pain;Pain management;Patients;peer support;Persons;Pharmaceutical Preparations;Pharmacy facility;pilot test;pilot trial;Predictive Analytics;predictive modeling;prevent;Primary Care;Probability;Provider;random forest;Randomized, Controlled Trials;Reporting;Research;Research Priority;Resources;Risk;Risk Factors;Sampling;Services;Site;skills;standard of care;statistics;Substance Use Disorder;Suicide;support tools;Techniques;Testing;Time;tool;Training;Translating;treatment guidelines;treatment planning;usability;Veterans;Visit;waiver

PROJECT_TITLE: Data to Clinical Action: Using Predictive Analytics to Improve Care of Veterans with Opioid Use Disorder


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: ANN ARBOR

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Two human cytochrome P450 enzymes produce distinct hormones controlling blood pressure and stress/immune responses, respectively. Decreasing production of these hormones can treat high blood pressure and other diseases, but it is challenging to make drugs that impair just one of these two highly similar enzymes, thus limiting undesirable side effects. The proposed work will determine key structural information of one of these enzymes, thereby facilitate the design of drugs complementary to just one enzyme.

PI_NAMEs: SCOTT, EMILY E (contact)

PROGRAM_OFFICER_NAME: KODURI, SAILAJA

PROJECT_TERMS: Active Sites;Adrenodoxin;Aldosterone;Aldosterone Antagonists;Amino Acid Sequence;Amino Acids;Anabolism;Binding;Biochemistry;Biological Process;Blood Pressure;blood pressure control;Characteristics;Chimeric Proteins;Clinical;clinical development;clinically relevant;Complex;Coupled;Cryoelectron Microscopy;CYP11B2 gene;Cytochrome P450;Data;design;Development;Disease;Drug Design;Electrons;Enzyme Interaction;enzyme structure;Enzymes;experience;flexibility;Frustration;Goals;Heart Diseases;Hormones;Human;human disease;Hydrocortisone;Hypertension;Immune;Immune response;Impairment;improved;inhibitor;Kidney Diseases;Knowledge;Ligands;Membrane;Membrane Proteins;Metabolic;Mixed Function Oxygenases;Molecular Conformation;Mutagenesis;novel strategies;Oxidation-Reduction;Pathway interactions;Pharmaceutical Preparations;Pharmacologic Substance;Pituitary-dependent Cushing's disease;prevent;Production;Protein Isoforms;Proteins;Publishing;Research;response;Roentgen Rays;Role;side effect;small molecule;steroid hormone;Stress;Structure;Surface;Techniques;Work;X-Ray Crystallography

PROJECT_TITLE: Structure and Function of Human Cytochrome P450 11B Enzymes Involved in Cushing’s Disease and Hypertension

STUDY_SECTION: XNDA

STUDY_SECTION_NAME: Xenobiotic and Nutrient Disposition and Action Study Section[XNDA]


NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Clinical Research;Hearing Loss;Neurosciences;Pediatric;Prevention;Rehabilitation

ORG_CITY: Columbus

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE The proposed study is relevant to public health because it aims to better understand neural encoding and processing of electrical stimulation in children with cochlear nerve deficiency (CND) - a poorly understood hearing disorder affecting up to 19% of children with congenital sensorineural hearing loss. Results from this study will have 1) a broad impact on the field by establishing how variations in neural survival of cochlear nerve fibers affect neural encoding of electrical stimulation in both the cochlear nerve and the central auditory system; and 2) a targeted impact on children with CND who are cochlear implant users by laying the groundwork for developing an effective, evidence-based clinical practice for managing these patients. This project is relevant to the mission of NIH because it seeks fundamental knowledge about the nature of electrical hearing in patients with CND and strives to apply this knowledge to reduce disability in these patients.

PI_NAMEs: HE, SHUMAN  (contact)

PROGRAM_OFFICER_NAME: KING, KELLY ANNE

PROJECT_TERMS: Action Potentials;Affect;Age;Apical;Auditory;auditory discrimination;auditory processing;Auditory system;base;behavioral response;Biological Markers;Child;Childhood;Clinical;clinical care;clinical practice;Clinical Practice Guideline;Clinical Research;clinically significant;Cochlea;Cochlear implant procedure;Cochlear Implants;Cochlear Nerve;comorbidity;Cues;Data;Detection;Deterioration;disability;Discrimination;Effectiveness;Electric Stimulation;Electrodes;Event-Related Potentials;evidence base;Exclusion;Foundations;functional status;Goals;Hearing;Hearing problem;High Prevalence;Implant;Implanted Electrodes;improved;Individual;Interphase;Knowledge;Labyrinth;Language Development;Length;Location;Magnetic Resonance Imaging;malformation;Maps;Measurable;Measures;Mission;Modiolus;Nature;Nerve Fibers;neural;patient population;patient variability;Patients;Pattern;Peripheral;Phase;Physiologic pulse;Practice Management;Predisposition;Process;programs;Public Health;Pulse Rates;Recovery;research study;Resolution;response;Sensorineural Hearing Loss;Signal Transduction;Site;Speech;Speech Development;Stimulus;Testing;tool;transmission process;United States National Institutes of Health;Variant;Work

PROJECT_TITLE: Neural Encoding and Auditory Processing of Electrical Stimulation in Pediatric Cochlear Implant Users


NIH_SPENDING_CATS: Aging;Bioengineering;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Neurosciences;Physical Rehabilitation;Rehabilitation;Stroke

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: Narrative Motor deficits after stroke are a major source of disability. Stimulation of the brain during therapy may accelerate recovery, especially of hand function. We will test a new form of stimulation that uses timing based on brain activity to improve recovery from stroke.

PI_NAMEs: CRAMER, STEVEN C.;OJEMANN, JEFFREY G (contact)

PROGRAM_OFFICER_NAME: WU, GUANGYING

PROJECT_TERMS: Acceleration;Activities of Daily Living;Affect;Animals;Area;Behavior assessment;Brain;BRAIN initiative;Brain region;Clinical;Clinical assessments;Clinical Research;Clinical Trials;Collaborations;Contralateral;Development;Device Designs;Devices;disability;Effectiveness;Electrical Stimulation of the Brain;Electrocorticogram;Electrodes;Engineering;Ethics;Evoked Potentials;expectation;experimental study;follow-up;functional improvement;Hand;Hand functions;Human;human subject;Impairment;Implant;implantable device;implantation;Implanted Electrodes;improved;Infarction;Measures;Motor;motor deficit;motor recovery;Movement;multidisciplinary;neural implant;nonhuman primate;novel;novel strategies;Painless;Paresis;Patient-Focused Outcomes;Patients;Pattern;Phase;Physiological;Pilot Projects;post stroke;primary endpoint;primary outcome;programs;public-private partnership;Quality of life;Recording of previous events;Recovery;Recovery of Function;Rehabilitation therapy;Research;Research Personnel;response;Risk;Signal Transduction;Site;software development;Source;Stroke;stroke recovery;stroke therapy;Surface;System;Technology;Testing;Time;time use;tool;United States National Institutes of Health;Upper Extremity;Work

PROJECT_TITLE: Motor Recovery through Plasticity-Inducing Cortical Stimulation

STUDY_SECTION: NSD

STUDY_SECTION_NAME: Neurological Sciences and Disorders C Study Section[NSD-C]


ORG_CITY: HOUSTON

PHR: Pancreatic cancer is a deadly cancer with increasing incidence for which no systematic efforts to reduce diagnostic delays exist. Our preliminary work shows that 40% of Veterans with pancreatic cancer experience diagnostic delays of  90 days and 40% experience missed opportunities to initiate or complete their diagnostic evaluation in a timely manner. Opportunities for more timely diagnosis of pancreatic cancer are possible in the VA, and the work put forth in this proposal tries to identify and transform these opportunities into decision support tools. In this project, we will: (1) identify potential missed opportunities for pancreatic cancer diagnosis; (2) develop electronic trigger (e-trigger) tools aimed at identifying high-risk patients with potential missed opportunities for pancreatic cancer diagnosis; and (3) assess local stakeholders’ views of facilitators and barriers to implementation of e-triggers for future application in clinical practice. These aims will be aligned with career development and training activities including formal coursework and a structured mentorship plan.

PI_NAMEs: KHALAF, NATALIA  (contact)

PROJECT_TERMS: Address;Affect;Algorithms;anti-cancer research;Area;cancer care;cancer diagnosis;Cancer Etiology;cancer type;career;career development;Caring;Cessation of life;Clinical;Clinical Informatics;clinical practice;cohort;Communication;comorbidity;Computer software;Coupled;Curative Surgery;Data;Development;Diagnosis;Diagnostic;Dimensions;Early Diagnosis;Educational Status;Effectiveness;effectiveness evaluation;effectiveness/implementation study;Electronic Health Record;Electronics;Engineering;Environment;Evaluation;Excision;experience;formative assessment;Frequencies;Future;Goals;Health;Health Personnel;Health Services;Health Services Research;Healthcare;Healthcare Systems;high risk;Human Resources;Hybrids;implementation barriers;improved;Incidence;Informatics;informatics tool;innovation;Interdisciplinary Study;Interview;Judgment;Knowledge;Link;Literature;Malignant neoplasm of pancreas;Malignant Neoplasms;Medical Records;Medicine;Mentors;Mentorship;Methodology;novel;Outcome;pancreatic cancer patients;patient subsets;Patient-Focused Outcomes;Patients;Pattern;Play;Predictive Value;Prevention;Process;Provider;Public Health Informatics;Random Allocation;Records;Research;Research Infrastructure;Research Personnel;Resources;Risk;Risk Factors;Role;Safety;Structure;Study models;support tools;Symptoms;System;Testing;Time;tool;Training Activity;Trust;United States National Academy of Sciences;Veterans;Work

PROJECT_TITLE: Health informatics approaches to reduce missed opportunities in diagnosis of pancreatic cancer


ADMINISTERING_IC: MD

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Assistive Technology;Behavioral and Social Science;Bioengineering;Clinical Research;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hearing Loss;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Racial and Ethnic Minority Health Research;Rehabilitation;Rural Health;Social Determinants of Health

ORG_CITY: LORETTO

ORG_NAME: APPLIED UNIVERSAL DYNAMICS CORPORATION

ORG_STATE: MN

PHR: Project Narrative Nearly 44 million Americans experience some hearing loss, but as much as 86% of adults who could benefit from hearing aid devices (HAD) do not use them. HAD usage is disproportionately lower among rural and minority (black, Hispanic/Latino) populations. Concerns about access, cost, comfort, effectiveness and satisfaction are key barriers to HAD usage. Self-adjustment enables users to pick HAD gain (amplification) settings according to the users’ widely varying individual preferences, which has been shown to significantly increase listener satisfaction and acceptance. Automating HAD gain settings with the use of machine learning (ML) techniques will reduce costs while improving intelligibility, comfort and increase the ease of use. As OTC HADs become available, this will lead to much higher adoptions of HADs in the rural and minority communities, improving their quality of life.

PI_NAMEs: PAVAN, ALLALAGHATTA  (contact)

PROGRAM_OFFICER_NAME: OLADEINDE, YEWANDE A

PROJECT_TERMS: Address;Adoption;Adult;American;Android;Audiology;Auditory;Automation;care delivery;Caring;Cellular Phone;Clinic;Communities;Computer software;Consumption;cost;Data;deep neural network;Devices;Effectiveness;efficacy testing;Engineering;Environment;Evaluation;evaluation/testing;experience;Face;feasibility testing;Feedback;Funding Opportunities;Future;Goals;graphical user interface;Health Professional;Health Services Accessibility;Hearing;Hearing Aids;hearing impairment;Hispanic;hispanic community;human subject;Improve Access;improved;Individual;Insurance Coverage;Language;Latino;Lead;Leadership;Learning;Low income;Machine Learning;machine learning model;machine learning prediction;medical specialties;Mexican Americans;microphone;Minnesota;Minority;minority communities;Minority Groups;model development;Modeling;Network-based;older adult;operation;Outcome;Output;Paired Comparison;Participant;Performance;Persons;Phase;Population;predictive modeling;preference;Price;Principal Investigator;Process;professor;prototype;Provider;Quality of life;recruit;Research;research and development;Rural;rural America;rural area;Rural Community;Rural Population;satisfaction;Science;Services;Small Business Technology Transfer Research;smartphone application;sound;Speech;statistics;success;System;Systems Integration;Techniques;Technology;Testing;Time;Underserved Population;Universities;verbal

PROJECT_TITLE: Improving Access and Automating Fitting for Hearing Aid Devices for the Underserved and Rural Populations

STUDY_SECTION_NAME: Special Emphasis Panel[ZMD1 JT (A1)]


NIH_SPENDING_CATS: Bioengineering;Brain Cancer;Brain Disorders;Cancer;Nanotechnology;Neurosciences;Orphan Drug;Radiation Oncology;Rare Diseases

ORG_CITY: Loma Linda

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: LOMA LINDA UNIVERSITY

PHR: Project Narrative Boron neutron capture therapy (BNCT) is a noninvasive therapy which relies on the nuclear capture and fission reactions for treating locally invasive malignant tumors such as glioma. In last 30-40 years, the lack of effective intracellular delivery methods for Boron-10 molecules specifically to the glioma cells has been the major limiting factor for the successful BNCT. Our proven, nanodrug based methodology to transport drugs across multiple biological barrier including blood-brain barrier to gliomas provides the missing link, thereby making BNCT a practical therapy for glioma treatment. Page 1

PI_NAMEs: PATIL, RAMESHWAR TUKARAM (contact)

PROGRAM_OFFICER_NAME: CAPALA, JACEK

PROJECT_TERMS: Acids;aggressive therapy;alternative treatment;Animal Model;Animals;Binding;biodegradable polymer;Biological;Biological Assay;Biological Markers;Biology;Blood;Blood - brain barrier anatomy;blood-brain barrier crossing;Boron;Boron Neutron Capture Therapy;Brain;Brain Neoplasms;brain tissue;cancer cell;Cell Line;Cells;Chemicals;Chemotherapy and/or radiation;Circulation;Clinic;Clinical;clinical application;Clinical Research;comparison intervention;Data;design;DNA Damage;dosage;Dose;Drug Kinetics;Drug Transport;Drug Utilization;efficacy study;Engineering;Excision;Exposure to;Flow Cytometry;Fluorescence;Fluorescent Dyes;Generations;Glioblastoma;Glioma;Goals;High Pressure Liquid Chromatography;Human;Image;imaging agent;improved;In Vitro;in vivo;Indocyanine Green;Inductively Coupled Plasma Mass Spectrometry;irradiation;Label;Lead;Leucine;Link;Malignant Neoplasms;Methodology;Methods;Microscopy;Modeling;Mus;nano;nanodrug;nanolabel;nanomedicine;nanotechnology platform;Necrosis;neoplastic cell;Neutrons;Newly Diagnosed;next generation;Normal tissue morphology;novel;Nuclear;Nuclear Reactors;Operative Surgical Procedures;Patients;Pennsylvania;Peptide Transport;Peptides;Personal Satisfaction;Pharmaceutical Preparations;Pharmacodynamics;Property;Quality of life;Radiation;Radiation therapy;Reaction;Research Personnel;Rhodamine;Saline;Science;side effect;small molecule;Sodium;Source;success;survival outcome;Tail;Therapeutic Agents;Time;Tissues;Toxic effect;Treatment outcome;treatment response;tumor;Tumor Tissue;Universities;uptake;Veins;Vertebral column;Work

PROJECT_TITLE: Targeted nano-boron based boron neutron capture therapy for glioma treatment


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Dental, Oral, and Craniofacial Disease;Infectious Diseases;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE This study will be a secondary data analysis of the nationally-representative and longitudinal dataset, National Longitudinal Study of Adolescent to Adult Health (1994-2018). We will examine the extent to which adolescent social networks are predictive of dental utilization. The overall impact of this research will increase our understanding of the relationship between social networks and oral health outcomes, apply rigorous social network analytic methods to dental health research, and inform novel approaches to interventions that improve dental utilization in an age range that has persistent untreated dental caries.

PI_NAMEs: CULYBA, ALISON J. (contact)

PROGRAM_OFFICER_NAME: IIDA, HIROKO

PROJECT_TERMS: Address;Adolescence;Adolescent;Adolescent Behavior;adolescent health;Adult;Affect;Age;aged;American;analytical method;Area;Characteristics;Child;cohort;Community Networks;Data;Data Analyses;Data Collection;Data Set;Dental;Dental Care;Dental caries;Dentists;Development;disadvantaged background;Drug Addiction;economic outcome;Evaluation;Family;Female;Friends;Friendships;Future;Health;Health behavior;health data;health disparity;health economics;health seeking behavior;Health Status;Healthcare;high school;HIV/AIDS;Home;improved;Individual;Infection;Influentials;interdisciplinary approach;interest;Interpersonal Relations;Intervention;Interview;life span;Link;Literature;Longitudinal cohort study;longitudinal dataset;Longitudinal Studies;Longitudinal Surveys;male;Modeling;Mouth Diseases;National Institute of Dental and Craniofacial Research;National Longitudinal Survey of Adolescent to Adult Health;Neighborhoods;novel strategies;nutrition;Obesity;Oral health;Outcome;Pain;Participant;Pathway Analysis;peer;peer influence;peer networks;Performance;permanent tooth;Persons;Policies;Prevalence;Questionnaires;Reporting;Research;Resources;Schools;Smoking;Social Interaction;Social Network;social network intervention;socioeconomics;Statistical Models;Strategic vision;Students;support network;Techniques;therapy development;Time;Tooth eruption;transition to adulthood;Visit;Work

PROJECT_TITLE: Examining Adolescent Social Networks and Dental Utilization in the National Longitudinal AddHealth Study


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Genetics;Human Genome;Prevention

ORG_NAME: METHODIST HOSPITAL RESEARCH INSTITUTE

PHR: PROJECT NARRATIVE Elucidating the action of m6A remodeling complex and the resulting m6A epitranscriptome will reveal how the m6A machinery is dysregulated by environmental exposures. This will ultimately aid in the design of effective diagnostics and facilitate prevention and treatment strategies for exposure-associated disease development.

PI_NAMEs: WENG, YI-LAN  (contact)

PROGRAM_OFFICER_NAME: TYSON, FREDERICK L

PROJECT_TERMS: 3' Untranslated Regions;Address;adverse outcome;Axon;biological adaptation to stress;Biological Markers;Biological Process;biomarker identification;Catalytic Domain;Cells;Characteristics;Co-Immunoprecipitations;Complex;Data;Dependence;design;Development;Diagnostic;Disease;disorder risk;Embryo;Environmental Exposure;epitranscriptome;epitranscriptomics;Etiology;Exposure to;gene environment interaction;genome-wide;Health;Hela Cells;Human;human disease;innovation;insight;interest;Investigation;Kidney;Length;Link;Literature;Mass Spectrum Analysis;Mediating;Mental disorders;Metabolism;Methodology;Methods;Methylation;methylation pattern;Methyltransferase;Modification;Molecular;Nervous System control;Nervous System Disorder;Neurodegenerative Disorders;Neurons;novel;Oxidative Stress;Oxidative Stress Induction;Pathogenesis;Pathogenicity;Pathologic;Pathway interactions;Pattern;Physiological;Play;Predisposition;Prevention strategy;Process;Protein Isoforms;protein TDP-43;Regulation;Regulatory Element;Research;response;Risk;RNA;RNA Transport;Role;Shapes;Signaling Molecule;sodium arsenite;Specific qualifier value;Stimulus;Stress;Synapses;System;Toxic Environmental Substances;toxicant;Toxicant exposure;Transcript;transcriptome;treatment strategy;Validation;Work

PROJECT_TITLE: Systems-wide analysis of oxidative stress-responsive m6A epitranscriptome


NIH_SPENDING_CATS: Biomedical Imaging;Cardiovascular;Clinical Research;Heart Disease

PHR: Premature ventricular contractions (PVCs) are prevalent in the general population and they are often considered benign, but frequent PVC may impair heart muscle function in certain individuals. It is often unclear when patients present with heart failure and PVCs if removing PVCs through an invasive procedure or suppressing them with medications would improve heart function. This study is aimed at studying PVCs with new imaging techniques to identify which PVCs are pathologic and should be treated and which PVCs are benign and can be left alone.

PI_NAMEs: HAN, YUCHI  (contact)

PROGRAM_OFFICER_NAME: BALIJEPALLI, RAVI C

PROJECT_TERMS: Ablation;Address;Ambulatory Monitoring;Animal Model;Anti-Arrhythmia Agents;Apical;Arrhythmia;Benign;Biological Markers;Breathing;cardiac magnetic resonance imaging;Cardiac Output;Cardiomyopathies;Catheters;Characteristics;Chest Pain;Clinical;clinical practice;Clinical Trials;cohort;Complex;Coupling;Development;Diagnosis;Diagnostic;diagnostic accuracy;diagnostic criteria;Diagnostic Imaging;diagnostic tool;diagnostic value;Disease;Echocardiography;EFRAC;Electrocardiogram;Electrophysiology (science);extracellular;follow-up;Foundations;Frequencies;Gadolinium;General Population;Generations;Goals;Heart;Heart failure;heart function;hemodynamics;human subject;Image;Image Enhancement;Imaging Techniques;Impairment;improved;Individual;Knowledge;Lead;Left;Left Ventricular Ejection Fraction;Left Ventricular Function;Longitudinal Studies;Magnetic Resonance Imaging;Maps;Mediating;Medical center;Modeling;Morphology;Muscle function;Myocardial;Myocardial tissue;Myocardium;noninvasive diagnosis;Normal tissue morphology;novel;Pathologic;Patient Selection;Patients;Pennsylvania;Performance;Pharmaceutical Preparations;predictive modeling;Prevalence;Prevention;Procedures;prospective;Relaxation;Reporting;Research;Risk;Risk Factors;risk prediction;Sinus;Site;structural heart disease;Sudden Death;Syncope;Techniques;Testing;Time;tissue mapping;Tissues;Toxic effect;Universities;University Hospitals;Ventricular;Ventricular Function;Ventricular Premature Complexes;voltage

PROJECT_TITLE: Imaging-based Indentification of Premature Ventricular Contraction-mediated

STUDY_SECTION: CCHF

STUDY_SECTION_NAME: Cardiac Contractility, Hypertrophy, and Failure Study Section[CCHF]


ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE The major goal of the proposed project is to evaluate the role of Trop2 receptor activation in aggressive prostate cancer. The study will also define novel mechanisms through which Trop2 contributes to the development of the advanced disease. Completion of the proposed research will give us insights into new mechanisms underlying the development of aggressive prostate cancer.

PI_NAMEs: STOYANOVA, TANYA I (contact)

PROGRAM_OFFICER_NAME: BERA, TAPAN K

PROJECT_TERMS: Advanced Development;advanced disease;advanced prostate cancer;Aggressive Clinical Course;androgen deprivation therapy;androgen independent prostate cancer;Androgens;Automobile Driving;Binding;Cancer Etiology;Carcinoma;Castration;Cell surface;Cell Surface Proteins;Cells;Cessation of life;ChIP-seq;Complex;Development;Disease;Extracellular Domain;Future;Generations;Genetic Transcription;Goals;Growth;hormone therapy;Human;in vivo;in vivo evaluation;Incidence;inhibitor;insight;Invaded;Knock-out;Life Expectancy;life span;Link;Maintenance;Malignant neoplasm of prostate;Malignant Neoplasms;Membrane Glycoproteins;men;Metastatic Prostate Cancer;migration;Molecular;mortality;Neoplasm Metastasis;Neurosecretory Systems;novel;novel therapeutic intervention;Oncogenic;Outcome;overexpression;Pathway interactions;Patients;Phenotype;Pre-Clinical Model;prostate cancer cell;prostate cancer model;prostate cancer progression;prostate carcinogenesis;Proteins;receptor;Receptor Activation;Recurrence;Relapse;Research;Resistance;response;Role;Signal Transduction;Study Section;Testing;therapeutic target;therapy resistant;transcription factor;transcriptome sequencing;tumor;tumor growth;tumorigenesis;United States

PROJECT_TITLE: Elucidating the Role of Trop2 in Prostate Cancer

STUDY_SECTION: TCB

STUDY_SECTION_NAME: Tumor Cell Biology Study Section[TCB]