NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Cardiovascular;Clinical Research;Comparative Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Heart Disease;Heart Disease - Coronary Heart Disease;Social Determinants of Health

ORG_DEPT: ADMINISTRATION

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: This project aims to compare the epidemiology, treatment intensity, and outcomes for patients hospitalized with five acute “tracer” conditions in five OECD countries with vastly different health system organization. Our work will provide important evidence comparing the intensity and outcomes of treatment across the countries, and will allow us to isolate the effect of health systems approaches, as distinct from other social investments that might impact health outcomes.

PI_NAMEs: CRAM, PETER M;LANDON, BRUCE E. (contact)

PROGRAM_OFFICER_NAME: NOVAK, PRISCILLA JOY

PROJECT_TERMS: Abdominal Aortic Aneurysm;Academy;Acute;acute care;Acute myocardial infarction;Admission activity;Affect;Age Distribution;Algorithms;Aortic Aneurysm;Canada;Cardiac Catheterization Procedures;Carotid Arteries;Clinical;Collaborations;common treatment;comorbidity;comparative;Comparative Study;Congestive Heart Failure;Consult;cost;Country;Data;Death Rate;Development;Disadvantaged;Disease;Disparity population;Economics;England;Epidemiology;experience;Future;head-to-head comparison;Health;health care service utilization;health difference;Health system;Healthcare;Healthcare Systems;Hip Fractures;hospital readmission;Hospitalization;hospitalization rates;Hospitals;human old age (65+);Image;improved;Income;Inequality;Infant Mortality;Inferior;Injury;insight;International;Investments;Ischemic Stroke;Israel;Knowledge;Learning;Length of Stay;Life Expectancy;Literature;low socioeconomic status;Measures;Medical;Medicine;Methods;mortality;Netherlands;older adult;older patient;Older Population;Outcome;Outpatients;Patient-Focused Outcomes;Patients;Pattern;peer;Performance;Policies;Population;population health;Population Study;procedure cost;Procedures;Province;repaired;Replacement Arthroplasty;Research;Research Methodology;Research Personnel;Research Support;Resource Allocation;revascularization;safety net;Sex Distribution;Site;social;social deprivation;Social Work;Societal Factors;Socioeconomic Status;Time;Tracer;treatment comparison;Treatment Effectiveness;Treatment outcome;treatment pattern;Update;Visit;Work

PROJECT_TITLE: Comparing hospitalization rates, outcomes, and treatment intensity for elderly patients across OECD countries

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-G(04)]


ADMINISTERING_IC: GM

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Data Science;Emerging Infectious Diseases;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: STORRS-MANSFIELD

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOCHEMISTRY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CONNECTICUT STORRS

ORG_STATE: CT

PHR: This project will use computational methods to characterize molecular details of viral infection processes in enteroviruses, which include severe pathogens EV-A71 and EV-D68. Children are most susceptible to these viruses, which can cause severe respiratory symptoms, paralysis and can even be fatal, and at the current time there are no approved treatments for these viral infections. This project will provide fundamental knowledge about the enterovirus infection process, which can lead to new drug development strategies against these pathogens.

PI_NAMEs: MAY, ERIC ROBERT (contact)

PROGRAM_OFFICER_NAME: GERSHENSON, ANNE

PROJECT_TERMS: Affect;antiviral drug development;Biochemical;Capsid;Child;Classification;Communication;Comprehension;Computer software;Computing Methodologies;deep learning;Development;drug development;Enterovirus;Enterovirus 68;Enterovirus 71;Enterovirus Infections;Genome;Grain;Health;Human poliovirus;Infection;Innate Immune System;insight;interest;Investigation;Knowledge;Lipid Bilayers;Lipids;Membrane;Methods;Modeling;Molecular;Molecular Conformation;molecular recognition;Motivation;multi-scale modeling;novel therapeutics;Paralysed;pathogen;Pathway interactions;Peptides;Predisposition;Process;programs;Property;Protein Dynamics;Proteins;Regulation;Research;Resolution;Respiratory Signs and Symptoms;Shapes;simulation;Structure;supervised learning;System;Time;tool;Viral;Viral Proteins;Virus;Virus Diseases;Vision;Work

PROJECT_TITLE: Structural Dynamics of Viral Proteins: Development and Application of Multiscale Computational Methods for Studying Viral Capsids, Proteins and Membrane Systems

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Genetics;Hematology;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: BIRMINGHAM

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE Zhu-Tokita-Takenouchi-Kim (ZTTK) syndrome, characterized by intellectual disability, delayed motor-psycho development and multi-organ anomalies, is a recently identified rare disease caused by de novo heterozygous loss-of-function mutations in the SON gene (SON haploinsufficiency). This project is to examine the hematopoietic abnormalities associated with ZTTK syndrome using mouse models, and to dissect the underlying molecular mechanisms. The results generated from this study will advance our understanding of this rare disease and serve as a basis for our future efforts to develop therapeutic strategies.

PI_NAMEs: AHN, ERIN EUN-YOUNG (contact)

PROGRAM_OFFICER_NAME: GOLDBERG, ILANA GRACE

PROJECT_TERMS: Abnormal Cell;Adult;Affect;Alternative Splicing;Awareness;bioinformatics tool;Bone Marrow;Bone Marrow Transplantation;Cell Lineage;Cells;Child;Chromatin;Chromatin Remodeling Factor;Clinical;clinical diagnosis;Communities;Complex;Custom;Data;Dedications;Development;Diagnosis;differential expression;Disease;Disease Progression;DNA Binding;DNA Methylation;Embryo;Epigenetic Process;Erythrocytes;Erythroid;experience;Family;fetal;Fetal Liver;Foundations;Functional disorder;Functional impairment;Future;Genes;Genetic;Hematology;Hematopoiesis;Hematopoietic;hematopoietic stem cell expansion;Hematopoietic stem cells;histone modification;Immune System Diseases;Immunoglobulins;Impairment;improved;in vivo;Individual;Intellectual functioning disability;Knock-out;Knowledge;Life;loss of function mutation;Loss of Heterozygosity;Lymphocyte Count;Lymphoid;medical attention;Megakaryocytes;Mission;Molecular;Motor;mouse model;MPP2 gene;Multipotent Stem Cells;Mus;novel;Organ;Output;Patients;Phenotype;Play;progenitor;Property;public database;Publications;Quality of life;Rare Diseases;rare genetic disorder;reconstitution;Research;Resources;Risk;RNA Splicing;RNA-Binding Proteins;Role;self-renewal;Sepsis;Shapes;Son;Syndrome;Testing;Therapeutic;Transcription Initiation;Transcription Repressor;transcriptome sequencing;Uncertainty

PROJECT_TITLE: Genetic and molecular basis of hematopoietic abnormalities in ZTTK syndrome

STUDY_SECTION: BBHV

STUDY_SECTION_NAME: Basic Biology of Blood, Heart and Vasculature Study Section [BBHV]


ADMINISTERING_IC: MH

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: BAR HARBOR

ORG_NAME: JACKSON LABORATORY

ORG_STATE: ME

PHR: PROJECT NARRATIVE / RELEVANCE TO PUBLIC HEALTH Recent advances in applications of machine learning methods to animal behavior quantification at high spatial and temporal resolution have yielded novel insights into neural functions, however, democratization of this technology remains a challenge. To better disseminate the theoretical and technical knowledge of this field, and train researchers to apply machine learning methods to behavior quantitation and modeling, we propose The Short Course on the Application of Machine Learning for Automated Quantification of Behavior. Our goal is to build an educational program that fosters productive and interactive dialogue, teaches proper methodology, and provides support structure to nurture and lower the barrier of entry into this nascent and emergent field that has the potential to facilitate leaps in our understanding of behavior and complex diseases.

PI_NAMEs: KENNEDY, ANN KATHRYN;KUMAR, VIVEK  (contact)

PROGRAM_OFFICER_NAME: VAN'T VEER, ASHLEE VICTORIA

PROJECT_TERMS: Acceleration;Adoption;Algorithms;Animal Behavior;Animals;Automobile Driving;Awareness;Behavior;Behavioral;Behavioral Genetics;Biological;Biomedical Research;career;career development;Collaborations;Complex;complex data;Computer Analysis;computer science;Computer software;Computer Vision Systems;Creativeness;Data;Data Analyses;data modeling;Data Science;Data Set;data streams;Databases;deep learning;Democracy;design;Development;Disadvantaged;Disease;Education;Educational process of instructing;Educational workshop;Environment;Ethology;experience;Experimental Designs;experimental study;Explosion;Faculty;Fellowship;Fostering;Future Teacher;gender minority;Generations;Genetic;Genetic Research;Genomics;Goals;graduate student;Health;Human;improved;innovation;insight;Institution;Knowledge;Laboratories;Learning;learning materials;lectures;Machine Learning;machine learning method;Measurement;Mentors;Methodology;Methods;Minority-Serving Institution;Modeling;neural;neural network;neuroethology;Neurophysiology - biologic function;Neurosciences;Neurosciences Research;next generation;novel;Participant;Performance;Persons;Positioning Attribute;Postdoctoral Fellow;Productivity;programs;Psychiatry;Public Health;recruit;Reproducibility;Research;Research Personnel;Resolution;Resources;Running;Schedule;Science;Scientist;statistical learning;Statistical Methods;statistics;Structure;Students;symposium;synergism;Technology;technology development;temporal measurement;The Jackson Laboratory;tool;Trainers Training;Training;training data;Underrepresented Minority;virtual;Work


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Physical Activity;Rehabilitation

ORG_CITY: TALLAHASSEE

ORG_DEPT: NUTRITION

ORG_NAME: FLORIDA STATE UNIVERSITY

ORG_STATE: FL

PHR: Project Narrative The proposed research is relevant to public health because it will define the ability of resistance exercise to mitigate the signals that initiate glucocorticoid myopathy in the presence of Alzheimer’s muscle pathology. This knowledge will ultimately help clinicians more effectively treat glucocorticoid myopathy in the Alzheimer’s population. The proposed research is relevant to the NIH’s mission that pertains to seek fundamental knowledge about living systems and the application of that knowledge to enhance health, lengthen life, and reduce disability.

PI_NAMEs: GORDON, BRADLEY S (contact)

PROGRAM_OFFICER_NAME: BOYCE, AMANDA T

PROJECT_TERMS: 3xTg-AD mouse;abeta accumulation;Affect;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease patient;Categories;Cell Physiology;Classification;cognitive function;Complex;Contralateral;Data;Dexamethasone;disability;DNA receptor;Electric Stimulation;Exercise;falls;Frequencies;Gene Expression;Genes;Glucocorticoid Receptor;Glucocorticoids;Health;Hormones;Human;Impaired cognition;Knowledge;Laboratories;Life;Measures;Mediating;Metabolic;Mission;Modeling;Mus;Muscle;Muscle function;Myopathy;novel;Nuclear;Nuclear Translocation;Organism;Outcome;Pathology;Pathway Analysis;Phosphorylation;Pilot Projects;Population;preservation;prevent;Process;Production;promoter;Proteins;Public Health;Publications;Randomized;Receptor Activation;Recovery;Research;resistance exercise;response;Response Elements;RNA;sciatic nerve;Senile Plaques;Signal Transduction;Skeletal Muscle;Testing;tibialis anterior muscle;Time;transcriptome;transcriptome sequencing;United States National Institutes of Health;Wild Type Mouse

PROJECT_TITLE: Resistance exercise to mitigate glucocorticoid myopathy during Alzheimer’s

STUDY_SECTION: SMEP

STUDY_SECTION_NAME: Skeletal Muscle and Exercise Physiology Study Section[SMEP]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Patient Safety

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

ORG_STATE: NY

PHR: Project Narrative As a renewed Network Lead Academic Participating Site, MSK will maintain its status as a leader in the scientific development, conduct, and accrual of NCTN clinical trials, with the overall goal of developing new treatments for patients with cancer. This goal will be achieved through the continued successful development and execution of definitive, randomized, clinical treatment and advanced imaging trials across a broad range of diseases and diverse patient populations.!

PI_NAMEs: ABU-RUSTUM, NADEEM ;AGHAJANIAN, CAROL  (contact);FELDMAN, DARREN ;LEE, NANCY Y;USMANI, SAAD

PROGRAM_OFFICER_NAME: MOONEY, MARGARET M

PROJECT_TERMS: American College of Radiology Imaging Network;Clinical Treatment;Clinical Trials;Clinical Trials Network;Development;Disease;Eastern Cooperative Oncology Group;experience;Goals;Grant;Image;Infrastructure;Lead;Leadership;Malignant Neoplasms;meetings;member;Memorial Sloan-Kettering Cancer Center;Mentors;Mentorship;Mission;multidisciplinary;National Clinical Trials Network;Oncology;Participant;patient population;Patients;Principal Investigator;Randomized;rare cancer;Research;Research Personnel;Resources;Site;Translational Research

PROJECT_TITLE: Network Lead Academic Participating Site:  Memorial Sloan Kettering Cancer Center


ADMINISTERING_IC: EB

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_CITY: ATLANTA

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: GEORGIA INSTITUTE OF TECHNOLOGY

ORG_STATE: GA

PHR: Project Narrative This work aims to develop the underlying technology to move towards the development of portable, minimal-equipment protein diagnostics, with applications to nutritional deficiencies and other diseases. This approach could enable large-scale epidemiological studies across the globe that will inform policy-making on nutritional interventions to better treat millions of undernourished people as well as improve diagnostic capabilities for neonatal intensive care unit patients who cannot give large volumes of blood for testing. Additionally, this approach can be used as a basis for other minimal-equipment protein sensors, further broadening access to medical testing in resource-poor areas.

PI_NAMEs: STYCZYNSKI, MARK PHILIP-WALTER (contact)

PROGRAM_OFFICER_NAME: MULVANEY, SHAWN PATRICK

PROJECT_TERMS: Affect;Antibodies;Base Sequence;Biological Assay;Biological Markers;biological systems;Blood;Blood Tests;Blood Volume;burden of illness;C-reactive protein;Calibration;Cells;Cessation of life;Characteristics;Child;Chimeric Proteins;Clinical;clinical biomarkers;clinically relevant;Companions;Complex;cost;Coupled;Data;design;Detection;detection assay;Development;Diagnostic;Diagnostic Equipment;diagnostic value;Dietary intake;Dietary Intervention;Disease;DNA-Directed RNA Polymerase;Electricity;Engineering;Enzyme-Linked Immunosorbent Assay;Epidemiologist;Epidemiology;epidemiology study;Equipment;Ferritin;Freeze Drying;Friends;frontier;Future;global health;Goals;Growth;Health;health application;Hour;Human;Hydration status;Impairment;improved;Infant;Inflammation;insight;Intervention;iron deficiency;Laboratories;lateral flow assay;Letters;Literature;Location;Malnutrition;Mass Spectrum Analysis;Measurement;Measures;Medical;micronutrient deficiency;Micronutrients;Minerals;Modeling;Monitor;Neonatal Intensive Care Units;novel strategies;Nutrient;Nutritional;nutritional epidemiology;Nutritional status;Output;Patients;Performance;Persons;point of care;Policy Making;Population;Populations at Risk;portability;protein biomarkers;protein expression;Proteins;Reaction;Reporter;Resource-limited setting;Resources;Sampling;screening;sensor;Serum;Site;small molecule;smartphone application;success;synthetic biology;System;Techniques;Technology;Testing;Time;Translating;Visual;Vitamins;Work;Zinc

PROJECT_TITLE: Synthetic biological systems for protein detection

STUDY_SECTION: EBIT

STUDY_SECTION_NAME: Enabling Bioanalytical and Imaging Technologies Study Section[EBIT]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Machine Learning and Artificial Intelligence;Major Depressive Disorder;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Precision Medicine;Serious Mental Illness

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: Narrative  The wide variation in symptoms of major depressive disorder complicates efforts to develop new treatments and make effective use of existing treatments. Applying machine learning methods to electronic health records will enable the identification of interpretable disease subgroups, enabling development of more targeted treatment strategies.

PI_NAMEs: PERLIS, ROY H. (contact)

PROGRAM_OFFICER_NAME: FERRANTE, MICHELE

PROJECT_TERMS: Acceleration;Accidents;Address;Algorithms;Area;Biological;Biology;biomarker identification;biotypes;Black Box;Cessation of life;Classification;Clinical;clinical investigation;clinical subtypes;Code;cohort;Collaborations;Data;Data Set;Dementia;depressive symptoms;Development;Diagnostic;Dimensions;Disease;Disease remission;disorder subtype;Electronic Health Record;Endocrine System Diseases;Engineering;Equilibrium;Evidence based treatment;experience;Functional disorder;Health Care Costs;Health system;Heart Diseases;Heterogeneity;Hospitals;Human;Individual;ineffective therapies;Inflammatory Bowel Diseases;innovation;Machine Learning;machine learning method;Major Depressive Disorder;Malignant Neoplasms;Manuals;Measures;Medical;Medicine;Mental Depression;Methods;Modeling;Mood Disorders;Morbidity - disease rate;mortality;mortality risk;National Institute of Mental Health;novel therapeutics;Outcome;patient subsets;Patients;Performance;phenomenological models;Phenotype;precision medicine;Prevalence;Productivity;Public Health;Publications;Quality of life;Research Personnel;risk stratification;Selection for Treatments;Series;standard care;Subgroup;success;Suicide;Supervision;Symptoms;System;targeted treatment;Therapeutic;therapy resistant;treatment response;treatment strategy;Variant;Work

PROJECT_TITLE: Data-driven subtyping in major depressive disorder

STUDY_SECTION: BCHI

STUDY_SECTION_NAME: Biomedical Computing and Health Informatics Study Section[BCHI]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Brain Disorders;Conditions Affecting the Embryonic and Fetal Periods;Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Fetal Alcohol Spectrum Disorders (FASD);Genetics;Infant Mortality;Intellectual and Developmental Disabilities (IDD);Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Rare Diseases;Substance Misuse

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Holoprosencephaly (HPE), a common malformation of the forebrain and midface, has a complex etiology involving genetic and environmental risk factors. Fetal alcohol exposure is one such factor, but its interaction with predisposing genetic variants, the identity of its embryonic target cells, and the developmental pathways it affects are all poorly understood. Using mouse models of HPE, we aim to provide insight into these questions to enhance understanding of gene-environment interaction in causation of birth defects.

PI_NAMEs: KRAUSS, ROBERT S. (contact)

PROGRAM_OFFICER_NAME: SAIFUDEEN, ZUBAIDA

PROJECT_TERMS: Acute;Affect;alcohol exposure;Alcohols;Anterior;Apoptosis;Biological Models;Brain;CDON gene;Cell Physiology;Cell Proliferation;Cell surface;cell type;Cells;Cellular Assay;Clinical;Complex;Congenital Abnormality;Craniofacial Abnormalities;Defect;Development;developmental genetics;Embryo;embryo cell;Embryonic Development;Environmental Exposure;Environmental Risk Factor;Epiblast;Erinaceidae;Ethanol;Etiology;Event;experimental study;Failure;fetal;Fetal Alcohol Exposure;gastrulation;gene environment interaction;Gene Expression;Genetic;genetic pedigree;genetic risk factor;genetic variant;Genetic Variation;Heterozygote;Holoprosencephaly;Human;Hydrophobicity;In Situ Hybridization;in vitro Model;insight;malformation;Metabolism;Minor;Modeling;Molecular;Molecular Analysis;morphogens;Morphology;mouse model;Mus;Mutagenesis;Mutation;mutation carrier;Nature;Nodal;Outcome;Pathway interactions;Pattern;Penetrance;Phenotype;Phosphorylation;Population;Primitive Streaks;Prosencephalon;Quantitative Reverse Transcriptase PCR;receptor;response;Risk;SHH gene;Signal Pathway;Signal Transduction;smoothened signaling pathway;stem cells;Structure;synergism;Teratogens;Testing;transcriptomics;Wild Type Mouse

PROJECT_TITLE: Molecular and Developmental Analysis of Holoprosencephaly

STUDY_SECTION_NAME: Development - 1 Study Section[DEV1]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Bioengineering;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: PLEASANTON

ORG_NAME: Q-CHEM, INC.

ORG_STATE: CA

PHR: In this project, we seek to significantly reduce the computational time (ca. 500,000 CPU hours) required to obtain accurate free energy profiles of enzymatic reactions to ca. 25,000 CPU Hours. Building upon sophisticated quantum mechanics, this can lead to reliable and quick predictions of enzyme activities and design of inhibitors and mutant enzymes.

PI_NAMEs: FENG, XINTIAN  (contact)

PROGRAM_OFFICER_NAME: NGUYEN, HAN

PROJECT_TERMS: 2019-nCoV;Acceleration;Address;Adopted;Algorithms;Amber;Benchmarking;Biochemical Reaction;biological systems;Biology;Case Study;Catalysis;Chemicals;Chemistry;Chorismate Mutase;Communities;Complex;Computer software;cost;Coupled;design;Development;Discipline;Encapsulated;enzyme activity;enzyme model;enzyme substrate complex;Enzymes;Evaluation;Free Energy;Goals;Hour;improved;inhibitor;Machine Learning;machine learning method;machine learning model;Marketing;materials science;mechanical force;Methodology;Methods;Modeling;molecular dynamics;Molecular Machines;molecular mechanics;molecular modeling;mutant;Mutation;Pathway interactions;Peptide Hydrolases;Performance;Phase;Positioning Attribute;Potential Energy;Process;programs;quantum;quantum chemistry;Quantum Mechanics;Reaction;Research;Scheme;simulation;simulation software;Solvents;Speed;Surface;System;terpene synthase;Time;time interval;tool;Training;Update;Work

PROJECT_TITLE: Multiscale ab initio QM/MM and Machine Learning Methods for Accelerated Free Energy Simulations


ADMINISTERING_IC: ES

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Genetics;Prevention

ORG_CITY: RIVERSIDE

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA RIVERSIDE

PHR: PROJECT NARRATIVE DNA and RNA can be alkylated upon exposure to alkylating agents in the environment or produced from endogenous metabolism. The proposed research will provide important insights into the molecular mechanisms about how alkylated DNA lesions perturb genomic stability, how cells sense and repair these DNA lesions, and how post-transcriptional modifications of RNA contribute to neurological diseases. The outcome of the proposed study will provide important new knowledge for the prevention and treatment of human diseases arising from DNA alkylation damage.

PI_NAMEs: WANG, YINSHENG  (contact)

PROGRAM_OFFICER_NAME: TYSON, FREDERICK L

PROJECT_TERMS: Alkylating Agents;Alkylation;Area;Biology;Bypass;Cells;Chemicals;Chemistry;Disease;DNA;DNA Alkylation;DNA biosynthesis;DNA Damage;DNA lesion;DNA Repair;DNA-Directed DNA Polymerase;Environment;environmental chemical;Environmental Exposure;epitranscriptomics;Exposure to;Genetic Transcription;Genome Stability;Goals;Health;Human;human disease;insight;Knowledge;Metabolic Activation;Metabolism;Molecular;molecular pathology;Nervous System Disorder;Outcome;Post-Transcriptional RNA Processing;Prevention;Prevention approach;Proteins;Proteomics;repaired;Research;response;RNA;RNA methylation;Role;Signal Transduction;Toxic Environmental Substances;Trinucleotide Repeat Expansion

PROJECT_TITLE: Chemical Biology of DNA and RNA Alkylation


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Digestive Diseases;Genetics;Human Genome;Pancreatic Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: WASHINGTON

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: GEORGETOWN UNIVERSITY

ORG_STATE: DC

PHR: Pancreatic ductal adenocarcinoma (PDAC) is one of the most deadly human cancers. We have recently identified a transcriptional network involving Yap, Myc and Sox2 that is important for PDAC tumor maintenance. In the current proposal, we outline a plan to fully elucidate the epigenetic mechanisms that enables PDAC cells to bypass Yap addition and investigate the therapeutic potential of using epigenetic inhibitors to prevent or overcome PDAC resistance to Yap blockade. The proposed study, once completed, will provide critical insights into the molecular mechanisms underlying PDAC plasticity and facilitate the development of more effective treatment strategies to improve the dismal outcome of this disease.

PI_NAMEs: YI, CHUNLING  (contact)

PROGRAM_OFFICER_NAME: AULT, GRACE S

PROJECT_TERMS: Ablation;addiction;ATAC-seq;Biological Models;Bromodomains and extra-terminal domain inhibitor;Bypass;cancer therapy;Characteristics;chemical genetics;Chromatin Conformation Capture and Sequencing;chromatin remodeling;Clinical;Complex;Dedications;Development;Disease Outcome;driving force;effective therapy;Epigenetic Process;Equilibrium;experimental study;Extinction;flexibility;follow-up;gain of function;Gatekeeping;Genes;Genetic;Genetic Engineering;Genetic Screening;Genetic Transcription;Genomics;Grant;Homeostasis;Human;improved;in vivo;in vivo evaluation;inhibitor;insight;interest;Invaded;KRAS oncogenesis;Label;Lesion;loss of function;Maintenance;Malignant - descriptor;Malignant Neoplasms;Metabolic;Modeling;Molecular;Molecular Target;mouse model;Mus;Mutation;Necrosis;Neoplasm Metastasis;neoplastic cell;next generation;Nodule;novel therapeutic intervention;oncogene addiction;Oncogenic;Oncoproteins;Oral;Output;Pancreas;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;pancreatic ductal adenocarcinoma model;Pathway interactions;Pharmaceutical Preparations;Population;predictive modeling;prevent;progenitor;Proteins;Refractory;Relapse;Reporter;Research;Resistance;Resistance development;response;Role;Route;Signal Transduction;small molecule;stem;stem cell niche;stem-like cell;Stress;synergism;System;Techniques;theories;Therapeutic;Therapeutic Agents;therapy resistant;Time;transcription factor;transdifferentiation;treatment strategy;tumor;Tumor Cell Invasion;tumor growth;tumor microenvironment;tumor progression;virtual

PROJECT_TITLE: Mechanisms of Epigenetic Plasticity in PDAC

STUDY_SECTION: TPM

STUDY_SECTION_NAME: Tumor Progression and Metastasis Study Section[TPM]


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: FORT WAYNE

ORG_NAME: PARKVIEW HOSPITAL, INC.

ORG_STATE: IN

PHR: PROJECT NARRATIVE Knowing that connection is the key to recovery, we developed Peer PLUS (People Leveraging Urgent Support) in partnership with certified peer recovery coaches and individuals with lived experience of recovery from substance use disorder. The Peer PLUS mobile app provides a secure channel for just-in-time, two-way communication between peer recovery coaches and their clients – facilitating confidential messaging, transfer of information, and tracking of appointments and referrals to resources – and the companion website makes it possible for a team of peer recovery coaches to offer more comprehensive coverage for a pool of clients. Importantly, both the app and website are not tied to any specific care provider, and the modular software design and implementation toolkit will allow it to be readily taken up by any peer recovery support service organization.

PI_NAMEs: TOSCOS, TAMMY R (contact)

PROGRAM_OFFICER_NAME: PATEL, SHEENA

PROJECT_TITLE: Peer PLUS: A Client-Centered Digital Intervention for Addressing the Needs of Individuals with Substance Use Disorder

STUDY_SECTION: HITR

STUDY_SECTION_NAME: Healthcare Information Technology Research[HITR]


ORG_CITY: BETHESDA

ORG_NAME: HENRY M. JACKSON FDN FOR THE ADV MIL/MED

ORG_STATE: MD

PHR: PROJECT NARRATIVE This study addresses the mechanisms that control initiation of homologous recombination in mammals. Recombination defects, including reduced recombination efficiency and improper placement of recombination events, are invariably associated with infertility, miscarriage and aneuploidy-related birth defects. Progress in the recombination field will lead to a better understanding of the causes of faulty chromosome segregation and eventually to developing measures for their early diagnosis and prevention of resulting health conditions.

PI_NAMEs: PETUKHOVA, GALINA  (contact)

PROGRAM_OFFICER_NAME: ADKINS, RONALD

PROJECT_TERMS: Address;Alleles;Aneuploidy;Animals;Area;Automobile Driving;Back;Binding Sites;Birds;bisulfite sequencing;Canis familiaris;ChIP-seq;Chromatin;chromatin remodeling;Chromosome Segregation;Chromosomes;Conflict (Psychology);Congenital Abnormality;CpG Islands;Data;Defect;Didelphidae;DNA;DNA Binding;DNA Methylation;Early Diagnosis;Electrophoretic Mobility Shift Assay;Elements;Enhancers;Event;Evolution;Failure;Fertility;Fishes;follow-up;Frequencies;functional genomics;Gametogenesis;Generations;Genes;genetic information;Genetic Recombination;Genetic Variation;Genome;genome-wide;Genomic Segment;Haplotypes;Health;homologous recombination;Human;Individual;Induced Mutation;Infertility;Inherited;interest;Investigation;Knock-out;Linkage Disequilibrium;Location;Mammals;Maps;Measures;Meiosis;methylation pattern;Mus;mutant;novel;Pattern;Plants;Population;Positioning Attribute;pressure;Prevention;Process;promoter;Proteins;Rattus;Resolution;Role;segregation;Site;Specificity;Spontaneous abortion;Sterility;Structure;subfertility;Time;Yeasts

PROJECT_TITLE: Evolution of Homologous Recombination Mechanisms

STUDY_SECTION: GVE

STUDY_SECTION_NAME: Genetic Variation and Evolution Study Section[GVE]


NIH_SPENDING_CATS: Aging;Genetics

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: Cellular senescence has been shown to contribute to age-related bone loss. In this project, we propose to define the interactions between senescent immune cells and skeletal cells, testing our central hypothesis that senescence of immune cells contributes to skeletal deterioration and conversely, senescent skeletal cells attract and contribute to an inflammatory and/or senescent phenotype of immune cells. In addition to defining underlying mechanisms, these studies may identify novel therapeutic targets to prevent, or reverse, age- related osteoporosis.

PI_NAMEs: KHOSLA, SUNDEEP  (contact);MONROE, DAVID G

PROGRAM_OFFICER_NAME: WILLIAMS, JOHN

PROJECT_TERMS: Address;Adoptive Transfer;age acceleration;age related;Age-Related Bone Loss;Age-Related Osteoporosis;aged;Aging;aging mechanism;Animals;Apoptosis;Automobile Driving;Biological Markers;bone;Bone Marrow;CDKN2A gene;cell age;Cell Aging;Cell model;Cell Senescence Induction;Cell Separation;Cells;Characteristics;chemokine;Chromatin;Chronic Disease;Chronology;Coculture Techniques;Complement;cytokine;Cytometry;Defect;Degenerative Disorder;Deterioration;DNA Damage;DNA Repair;ERCC1 gene;Etiology;experimental study;Extracellular Matrix;functional decline;Genetic;Genetic Models;Human;Immune;Immune system;immunosenescence;In Vitro;in vivo;Inflammation;Inflammatory;Interphase Cell;Intervention;Laboratories;Lead;LOX gene;Lymphoid Cell;Mediating;Mediator;Modeling;mouse model;Mus;Myeloid Cells;neutrophil;new therapeutic target;novel;old mice;Organ;Osteocytes;osteoimmunology;Osteoporosis;paracrine;Phenotype;Population;premature;Premature aging syndrome;prevent;Proliferating;Proteins;Regulation;Repair Complex;Resistance;Role;senescence;senescence associated secretory phenotype;senescent cell;single-cell RNA sequencing;skeletal;Skeleton;stressor;telomere;Testing;Time;Tissues;Transgenic Mice;Up-Regulation;Work

PROJECT_TITLE: Defining the interactions of senescent immune cells and skeletal cells


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Cerebrovascular;Childhood Injury;Clinical Research;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Rare Diseases;Stroke;Unintentional Childhood Injury

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Arginase-1-dependent mechanisms of efferocytosis and regenerative tissue scar formation after neonatal brain hypoxia-ischemia are unknown. Using new techniques, such as TRAPseq and seqFISH we will for the first time define the role of ARG1 signaling in efferocytosis and scar formation and define cellular profiles in 3D within the tissue scar.

PI_NAMEs: MIKE, JANA KRYSTOFOVA (contact)

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: 3-Dimensional;Address;Affect;age related;animal care;Apoptotic;Area;arginase;Arginine;Biological Assay;Brain;Brain Hypoxia-Ischemia;Brain region;career;career development;cell type;Cells;Child;Cicatrix;Coagulation Process;Collagen Type I;Common carotid artery;Complex;Cytoskeleton;Data;Data Analyses;Defect;Ensure;Exhibits;experimental study;Exposure to;Extracellular Matrix;Extracellular Matrix Proteins;Funding;Gene Expression Profile;Goals;Growth;Histologic;Hypoxia;Hypoxic-Ischemic Brain Injury;Immune response;improved;in vivo;Individual;Inflammation;Ingestion;inhibitor;Injury;Ischemia;Knowledge;Laboratories;Learning;Long term disability;Mediating;Mentors;Methodology;Methods;Microglia;Modeling;Molecular;multiple omics;Mus;natural hypothermia;neonatal brain;neonatal hypoxic-ischemic brain injury;neonatal stroke;Nerve Regeneration;neural;neurodevelopment;Neuroglia;neuroimmunology;neuroinflammation;Neurons;neuropathology;neuroprotection;novel;Organ;Outcome;Pathway interactions;Performance;Phagocytes;Physicians;Polyamines;post stroke;Procedures;Process;Production;Proline;Proteins;regenerative;regenerative tissue;repaired;Research;Research Project Summaries;response;RNA;Role;Scientist;Signal Pathway;Signal Transduction;Site;spatiotemporal;stem cell migration;stem cells;Structure;Techniques;Testing;Therapeutic;Time;timeline;tissue regeneration;tissue repair;tissue-repair responses;Tissues;transcriptome;Translating;Tubular formation;Use of New Techniques;Western Blotting

PROJECT_TITLE: Arginase-1 signaling after neonatal stroke

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-1 Study Section[NST-1]


NIH_SPENDING_CATS: Chronic Pain;Genetics;Human Genome;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy;Physical Injury - Accidents and Adverse Effects

ORG_CITY: WINSTON-SALEM

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

ORG_STATE: NC

PHR: PROJECT NARRATIVE Peripheral nerve injury induces pain that lasts more than three months (chronic neuropathic pain) in patients, which affects their quality of life and has a substantial economic and social impact due to limited treatment options. Thus, the medical community needs novel and more effective therapies to prevent the development of chronic neuropathic pain. The proposed studies will provide the foundation for a new non-narcotic therapeutic strategy that has the potential to reduce the incidence of chronic pain following nerve injury.

PI_NAMEs: BOADA, MARIO DANILO;ROMERO-SANDOVAL, E. ALFONSO (contact)

PROGRAM_OFFICER_NAME: GREENWELL, THOMAS

PROJECT_TERMS: Acceleration;Acetic Acids;Acute Pain;Address;Affect;arm;Behavior;Behavioral;Bioinformatics;biological adaptation to stress;Biological Assay;Biology;Cell Reprogramming;Cells;chronic inflammatory disease;chronic neuropathic pain;chronic pain;chronic pain management;clinically relevant;Cluster Analysis;Communities;conditional knockout;cytokine;Development;Dinoprostone;economic impact;effective therapy;Electrophysiology (science);Endoplasmic Reticulum;endoplasmic reticulum stress;Exhibits;Foundations;gain of function;Gene Expression;Genes;genetic signature;Genetic Transcription;genome-wide;Human;Hypersensitivity;Immune;immune activation;immune cell infiltrate;Immunology;improved;In Situ;in vivo;Incidence;Individual;Inflammation;Inflammatory;inflammatory pain;inhibitor;injured;Injury;innovation;Knockout Mice;Label;Leucocytic infiltrate;Leukocytes;Ligation;loss of function;Medical;misfolded protein;Modeling;Molecular;mouse model;Mus;Nanotechnology;Nerve Degeneration;nerve injury;neurobiotin;Neuroimmune;Neurons;Nociceptors;novel;Operative Surgical Procedures;Outcome;Pain;painful neuropathy;partial recovery;Patients;Pattern;Pattern recognition receptor;Peripheral;Peripheral nerve injury;Persistent pain;pharmacologic;Phenotype;Phosphotransferases;Physical assessment;Positioning Attribute;prevent;Preventive;Process;Production;programs;Prostaglandins;Protein Biosynthesis;Proteins;Quality of life;Recovery;Recovery of Function;recruit;Regulation;Resolution;response;Role;sciatic nerve;Signal Transduction;single-cell RNA sequencing;small molecule;Social Impacts;Surgical incisions;Technology;Testing;Therapeutic;Tissues;Toll-like receptors;tool;transcriptomics;XBP1 gene

PROJECT_TITLE: Endoplasmic Reticulum Stress Responses in Pain

STUDY_SECTION: SPS

STUDY_SECTION_NAME: Somatosensory and Pain Systems Study Section[SPS]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative The small intestine is separated into two main parts, the lumen where food passes through, and the lamina propria, where immune cells reside. A single layer of cells separates these two parts and provides a selective barrier that prevents bacteria and food particles from passing though, while allowing nutrients to leave the lumen. This proposal investigates how a breakdown of that barrier may lead to severe reactions in food allergy, whereby food proteins inappropriately move from the lumen and activate immune cells in the lamina propria, leading to anaphylaxis.

PI_NAMEs: PTASCHINSKI, CATHERINE MARY (contact)

PROGRAM_OFFICER_NAME: MINNICOZZI, MICHAEL

PROJECT_TERMS: 18 year old;adherent junction;Adverse effects;Affect;Allergens;Allergic;Allergic Disease;Allergic Reaction;allergic response;Anaphylaxis;Animal Model;Animals;Antigens;Bacteria;Binding;Cell Count;Cells;Child;cytokine;Data;Defect;Dendritic Cells;Desmosomes;Development;Diagnosis;Disease;Emergency Care;Endothelium;Epithelial Attachment;Epithelial Cells;Epithelium;Exhibits;experimental study;Food;food allergen;food antigen;food challenge;Food Hypersensitivity;Gastrointestinal tract structure;Goals;Growth;Hospitalized Child;IgE;Immune;immune activation;Immune response;Immune system;Immunity;immunoreaction;Incidence;Ingestion;Integral Membrane Protein;intestinal barrier;Intestinal Content;intestinal epithelium;Intestinal permeability;Intestines;junctional adhesion molecule;Lamina Propria;Maintenance;mast cell;Mediating;Methods;microbial;Minority;Modeling;mouse development;mouse model;Mucous Membrane;Mus;Nutrient;oral immunotherapy;Organism;particle;Patients;Peripheral;Persons;Play;Population;Predisposition;prevent;Proteins;Public Health;Reaction;Regulation;Research;response;Role;Serious Adverse Event;Serum;Severities;Side;Small Intestines;Stem Cell Factor;Structure;success;Tamoxifen;Therapeutic;Tight Junctions;Time;Tissues;TNFSF4 gene;United States;uptake;villin

PROJECT_TITLE: Role of epithelial barrier function in food-induced anaphylaxis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IIDB-K(57)]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Opioid Misuse and Addiction;Opioids;Precision Medicine;Substance Misuse

ORG_CITY: BALTIMORE

ORG_DEPT: PSYCHIATRY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: NARRATIVE Persons who withdraw from opioids have different experiences, but little is known about the magnitude of these differences or what might predict different responses across individuals. This study will combine a laboratory session with a clinical treatment trial to learn more about these differences. We will also examine differences between men and women, with a goal of helping providers better match patients to different opioid use disorder treatment medications.

PI_NAMEs: DUNN, KELLY E (contact)

PROGRAM_OFFICER_NAME: RAMEY, TANYA S

PROJECT_TERMS: Attention;Behavioral;Buprenorphine;Categories;Classification;Clinical;Clinical Treatment;clinically relevant;Clonidine;Data;Data Set;design;Development;Drug usage;Enrollment;Evaluation;experience;Exposure to;follow-up;Goals;Health Services Accessibility;Human;Individual;Individual Differences;Laboratories;Learning;Life Expectancy;lofexidine;Measurement;medication for opioid use disorder;men;Morbidity - disease rate;mortality;Motivation;Naloxone;Naltrexone;Negative Reinforcements;novel;Opioid;Opioid agonist;Opioid Antagonist;opioid epidemic;opioid use disorder;opioid withdrawal;Outcome;Outpatients;Participant;Patients;personalized medicine;Persons;Pharmaceutical Preparations;Pharmacotherapy;Phenotype;Physiological;Placebos;Positive Reinforcements;prescription opioid;prospective;Provider;Public Health;Publishing;relapse prevention;Reporting;response;Role;Sampling;secondary analysis;Severities;sex;Time;Tramadol;treatment strategy;treatment trial;Withdrawal;Withdrawal Symptom;Woman;women versus men

PROJECT_TITLE: Assessing a Clinically-meaningful Opioid Withdrawal Phenotype

STUDY_SECTION: ARM

STUDY_SECTION_NAME: Addiction Risks and Mechanisms Study Section[ARM]


NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Heart Disease;Infectious Diseases;Rare Diseases;Vector-Borne Diseases

ORG_CITY: CORDOBA

ORG_COUNTRY: ARGENTINA

ORG_FIPS: AR

ORG_NAME: NATIONAL RESEARCH COUNCIL OF ARGENTINA

PHR: Project Narrative The proposal seeks to determine the role of the purinergic system in the development of Chagas cardiomyopathy and how targeting these pathways impacts disease progression. Through the study of cardiac explants from transplanted patients and murine experimental models the project will provide detailed insight into the biology of the cardiac response to infection. The investigations will provide a comprehensive understanding of regulatory mechanisms through which Trypanosoma cruzi infection subverts immune response to sustain parasite persistence within host tissues.

PI_NAMEs: AOKI, MARIA PILAR (contact)

PROGRAM_OFFICER_NAME: PESCE, JOHN T

PROJECT_TERMS: Adenosine;affection;Argentina;Benznidazole;Biology;Cardiac;Cardiac Myocytes;Cardiomyopathies;Cell Density;Cell Lineage;Cell Separation;Cells;Cellular Immunity;Chagas Disease;Chagas Myocarditis;chagasic cardiomyopathy;chemotherapy;Chronic;Cicatrix;clinically relevant;Complication;Consumption;Country;Development;Disease Progression;Drug Delivery Systems;Drug Kinetics;Environment;Equilibrium;Etiology;Experimental Models;extracellular;Fostering;Frequencies;Gene Expression Profile;Growth;Heart;Heart failure;Human;Hypoxia;Immune;Immune response;Immunity;Immunohistochemistry;immunopathology;immunoregulation;improved;Infection;inflammatory milieu;Inflammatory Response;insight;Intervention;Investigation;Ischemia;Knowledge;Latin America;Lesion;Leukocytes;Link;Macrophage;microbicide;Modeling;mouse model;Movement;Mus;Myeloid Cells;Myocarditis;novel;novel strategies;Nucleosides;Outcome;Oxygen;Parasites;Particulate;pathogen;Pathogenesis;Pathogenicity;Pathologic;Pathology;Pathway interactions;Patients;Pharmaceutical Preparations;pharmacologic;Population;Preventive vaccine;Public Health;Purinoceptor;Regulatory Pathway;Reporting;response;Role;side effect;Signal Pathway;Signal Transduction;Sterility;Stroke;Sudden Death;System;T-Lymphocyte;Testing;Time;Tissues;Transplant Recipients;Treatment Efficacy;Trypanosoma cruzi;Vaccine Therapy;Validation

PROJECT_TITLE: Targeting purinergic signaling in Chagas disease

STUDY_SECTION: PTHE

STUDY_SECTION_NAME: Pathogenic Eukaryotes Study Section[PTHE]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Disability Research;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Neurosciences;Orphan Drug;Precision Medicine;Rare Diseases;Tuberculosis

ORG_CITY: HACKENSACK

ORG_NAME: HACKENSACK UNIVERSITY MEDICAL CENTER

ORG_STATE: NJ

PHR: NARRATIVE Tuberculous meningitis (TBM) is the most lethal and disabling form of tuberculosis arising when Mycobacterium tuberculosis crosses the blood-brain barrier. To better understand TBM disease mechanisms and response to drug treatment, we have access to unique clinical samples from TBM patients prior and during therapy. We propose to analyze these samples to measure the penetration of TB drugs in brain lesions, and refine a rabbit model of TBM, which will be used to discover new and better drugs that hit critical and vulnerable pathways to ameliorate TBM disease.

PI_NAMEs: GENGENBACHER, MARTIN ALFONS (contact);LAI, RACHEL PEI JEN;WILKINSON, ROBERT JOHN

PROGRAM_OFFICER_NAME: MAHON III, ROBERT N

PROJECT_TERMS: Adult;Animal Model;Antibiotics;antimicrobial;Aspirin;Basic Science;Biological Markers;Biology;blood-brain barrier crossing;Brain;Brain Injuries;brain tissue;Cells;Cellular biology;Central Nervous System;Cerebrospinal Fluid;Cessation of life;Clinical;Clinical Data;Clinical Research;clinical trial analysis;Clinical Trials;Collaborations;Combined Antibiotics;Coupled;Data;Death Rate;defined contribution;disability;Disabling;disabling disease;Disease;Disease Outcome;Disease Progression;dosage;Dose;drug candidate;Drug Exposure;Drug Interactions;Drug Kinetics;drug repurposing;efficacy evaluation;Ensure;evidence base;excitotoxicity;experimental study;Funding;Future;gamma-Aminobutyric Acid;Glutamates;HIV;Human;immune modulating agents;Immune response;Immunobiology;Immunology;immunopathology;improved;In Vitro;in vivo;in vivo magnetic resonance spectroscopy;Individual;Indoles;Infection;Inflammation;Injury;innovation;insight;Institution;Investigation;Knowledge;laser capture microdissection;Lesion;Linezolid;Long term disability;mass spectrometric imaging;Mass Spectrum Analysis;Measures;Meningeal Tuberculosis;Metabolic;metabolomics;Modeling;Molecular;mortality;multiple omics;Mycobacterium tuberculosis;Nervous System Trauma;Neurological disability;neurotoxic;novel;novel therapeutics;Oryctolagus cuniculus;Outcome;Output;Participant;pathogen;Pathogenesis;Pathway interactions;patient population;Patients;Penetration;Pharmaceutical Preparations;pharmacodynamic model;Pharmacodynamics;pharmacokinetic model;pharmacokinetics and pharmacodynamics;Pharmacology;Pharmacotherapy;Phase;phase III trial;Plasma;Population;pre-clinical;Pre-Clinical Model;predictive marker;Principal Investigator;programs;Propionic Acids;protein biomarkers;Proteomics;Publishing;Regimen;response;Rifampin;Role;Safety;Sampling;Signal Pathway;Site;South Africa;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;standard of care;Survivors;Testing;therapeutic evaluation;Therapeutic Intervention;Tissues;tool;Toxic effect;transcriptomics;Translating;translational approach;translational model;Translational Research;translational research program;treatment response;Tryptophan;Tuberculosis;tuberculosis drugs;Work

PROJECT_TITLE: Translational approaches to improve understanding and outcome in Tuberculous meningitis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDM-T(50)R]


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Data Science;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Social Determinants of Health

ORG_CITY: LA JOLLA

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

PHR: PROJECT NARRATIVE The Scripps hub brings together Scripps Research and its partners Scripps Health, Rady Children’s Genomic Medicine Institute, and newly added San Diego State University, along with many collaborating entities, to innovate and transform translational and clinical science. The three principal focus areas of SRTI—genomics, digital medicine, and informatics/analytics—are interdependent, and foster a multi-dimensional understanding of human beings, which is the true foundation of individualized medicine. The Scripps hub will relentlessly pursue innovations in translational and clinical science to promote accuracy, individualism, and democratization, with deep academic and industry collaborations, fully integrating the voice of the community and patients, with a paramount goal of reducing health inequities.

PI_NAMEs: TOPOL, ERIC JEFFREY (contact)

PROGRAM_OFFICER_NAME: CHANG, SOJU

PROJECT_TERMS: 2019-nCoV;Acceleration;Acute;Address;Area;Artificial Intelligence;artificial intelligence model;Awareness;biomedical informatics;Biosensor;California;career development;Child;Clinical Research;Clinical Sciences;Clinical Trials;Collaborations;Communities;community engaged research;community engagement;computer science;computerized data processing;cost effective;Country;County;Data;Data Aggregation;Data Set;data standards;Dedications;Democracy;Diagnostic;digital;digital medicine;digital platform;digital twin;Dimensions;Dissemination and Implementation;Diverse Workforce;diversity and inclusion;drug repurposing;Drug Screening;Ecosystem;Education;educational atmosphere;Elements;empowerment;equity, diversity, and inclusion;Ethics;ethnic diversity;Ethnic Origin;Fostering;Foundations;Genomic medicine;Genomics;Geography;Goals;Health;health data;health equity;health inequalities;Healthcare;Heart Rate;Human;Human Resources;improved;individualized medicine;Industry Collaboration;Informatics;innovation;Institute of Medicine (U.S.);Institution;interoperability;Intervention;life span;Medical;Medical Research;Methodology;Modeling;multimodal data;multimodality;Outcome;pandemic disease;Patients;Physiological;Population;pregnancy disorder;Preventive;Process;Productivity;Program Development;programs;Public Health;public health emergency;Public Health Informatics;Race;racial diversity;real time model;Research;Research Institute;Research Project Grants;Resource Informatics;Resources;response;Rest;Sampling;SARS-CoV-2 infection;Science;secondary analysis;sensor;Services;Site;Sleep Disorders;socioeconomics;Structure;Techniques;Time;tool;Training;translational approach;Translational Research;Universities;Vision;Voice;wristband

PROJECT_TITLE: Scripps Clinical and Translational Science Hub


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Depression;Mental Health;Palliative Care;Prevention

ORG_CITY: JACKSONVILLE

ORG_NAME: MAYO CLINIC  JACKSONVILLE

PHR: PROJECT NARRATIVE Older adult family caregivers experience highly stressful situations during the end stages of a loved one’s illness that limit their ability to effectively cope with grief and loss. This study will evaluate a brief psychological treatment for grief. The results of this study may lead to improvements in treating grief and loss among family caregivers, improving the health and quality of life of older adults.

PI_NAMEs: TOFTHAGEN, CINDY  (contact)

PROGRAM_OFFICER_NAME: RIDDLE, MELISSA

PROJECT_TERMS: Acceleration;Acute;acute stress;Address;advanced disease;Aging;arm;Assessment tool;Attention;attentional control;Bereavement;biological adaptation to stress;brief intervention;Caregiver Burden;Caregivers;Cessation of life;Characteristics;Chronic Disease;Chronic stress;Clinical Trials;Cognitive;cognitive process;coping;Data;Data Collection;Distress;Double-Blind Method;Early Intervention;Early treatment;Education;effective intervention;efficacy evaluation;efficacy testing;Elderly;Emotional;Enrollment;Equipment and supply inventories;Event;Evidence based treatment;experience;Family;Family Caregiver;Family member;Friends;Future;Geographic Locations;Goals;Grief reaction;Health;Hobbies;immune function;improved;Individual;instrument;Intervention;Interview;Life;loved ones;Mental Depression;mental function;Methods;Morbidity - disease rate;mortality;older adult;Outcome;Palliative Care;Participant;Persons;Physical Function;Pragmatic clinical trial;predicting response;prevent;Prevention;preventive intervention;primary outcome;Process;programs;psychologic;Psychological Factors;Psychotherapy;Quality of life;Randomized;randomized, clinical trials;Recovery;Research;Resolution;Resources;response;Risk;Science;screening;social;social factors;Social support;Stress;stress related disorder;Structure;Subgroup;success;Symptoms;Testing;Therapeutic Intervention;Time;time use;Trauma;traumatic event;treatment as usual;treatment response;Veterans;Waiting Lists

PROJECT_TITLE: Accelerated Resolution Therapy for Early Maladaptive Grief: A Clinical Trial

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Clinical Research;Congenital Structural Anomalies;Pediatric;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Urologic Diseases

ORG_CITY: LOS ANGELES

ORG_DEPT: UROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE Urethral stricture disease and hypospadias are conditions that affect children and adults. When urethral replacement or repair is required, alternative tissue options are limited and are associated with high risk of short and long-term complications. This proposal will create and evaluate a novel bioinspired, biomimetic, cell-seeded urethral tissue construct with optimized biomechanical properties to support urethral tissue regeneration in these conditions.

PI_NAMEs: STURM, RENEA  (contact)

PROGRAM_OFFICER_NAME: RANKIN, TRACY L

PROJECT_TERMS: Address;Adipose tissue;Adolescent;Adult;Advisory Committees;Affect;Anatomy;Animals;Anterior;Autologous;Award;Biocompatible Materials;Biological;biomaterial development;Biomechanics;Biomedical Engineering;Biomimetics;Birth;boys;California;care costs;career;Categories;Cell Adhesion;cell behavior;Cell Line;Cells;Cellular biology;Characteristics;Cheek structure;Child;Childhood;Chronic;clinical translation;cohort;Collagen;Communication;congenital anomaly;cost;Defect;Deposition;design;Development;Diagnosis;Disease;Diverticulum;Doctor of Philosophy;Educational workshop;Elasticity;Elastin;Engineering;Evaluation;Expenditure;Extracellular Matrix;fabrication;Fistula;Future;Gelatin;Goals;high risk;Human;Hydrogels;Hypospadias;immunoregulation;implantation;improved;In Vitro;in vivo;Infection;Insurance Carriers;Knowledge;Leadership;Learning;Libraries;Life;Los Angeles;Lower urinary tract;male;Malignant - descriptor;Malignant Neoplasms;materials science;mechanical properties;Mechanics;men;Mentors;Mentorship;Mesenchymal Stem Cells;Methacrylates;Methodology;Methods;Modeling;Modulus;Morbidity - disease rate;Morphology;Nanotopography;Natural regeneration;novel;Operative Surgical Procedures;Oryctolagus cuniculus;Outcome;Patients;Penile Erection;penis foreskin;Peptides;Phenotype;Physicians;polycaprolactone;Polymers;Postoperative Complications;prepuberty;Privatization;Procedures;professor;Property;Puberty;Reconstructive Surgical Procedures;repaired;replacement tissue;Reproducibility;Research;Research Design;Research Personnel;Role;scaffold;Scientist;Secondary to;Site;skills;Skin;Smooth Muscle;Source;standard of care;stem cells;Structure;Surgeon;symposium;Techniques;Tensile Strength;Testing;Tissue constructs;Tissue Engineering;tissue regeneration;tissue repair;Tissues;Training;translational goal;Trauma;Tube;Tubular formation;Universities;Urethra;Urethral Stricture;Urinary tract;Urologic Surgeon;Urology;Urothelium;Vascularization;Work;wound healing;wound vascularization

PROJECT_TITLE: Highly Elastic Biomaterial Development for Urethral Application

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences;Physical Activity;Women's Health Research

ORG_CITY: Aurora

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative  The overall focus of this proposal is to investigate neural-circuit mechanisms of exercise-induced stress resistance and underlying sex differences. Results will enhance our knowledge of sex differences in response to exercise and could contribute to the development of more effective strategies for the treatment of trauma- linked disorders.

PI_NAMEs: GREENWOOD, BEN N (contact)

PROGRAM_OFFICER_NAME: BREEDEN, ANDREW LEE

PROJECT_TERMS: Acceleration;Address;Anxiety;Anxiety Disorders;Automobile Driving;Behavior;Behavioral;behavioral outcome;Brain;Chemosensitization;Chronic;Communication;Corpus striatum structure;Data;Desire for food;Development;Disease;Dopamine;Dopamine D1 Receptor;dorsal raphe nucleus;emotion regulation;Exercise;experience;experimental study;Female;Fluorescent in Situ Hybridization;Future;Genes;Genetic;genetic approach;Goals;Knowledge;Link;Maintenance;male;Mediating;men;Mental Depression;Mental Health;Molecular;Mood Disorders;Motivation;Motor;neural;neural circuit;Neurons;novel;optogenetics;Organ;Outcome;Periodicity;Peripheral;Phase;Positioning Attribute;Predisposition;Prefrontal Cortex;prevent;Process;Property;Rattus;receptor expression;recruit;release factor;resilience;Resistance;resistance exercise;response;Role;Running;Scanning;sedentary;Sensorimotor functions;sensorimotor system;Serotonin;sex;Sex Differences;Signal Transduction;Stimulus;Stress;stress management;stress resilience;Substantia nigra structure;System;Testing;Time;Trauma;treadmill training;treatment strategy;Woman;women versus men

PROJECT_TITLE: Sex and circuit-specific determinants of exercise-induced stress resilience

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


NIH_SPENDING_CATS: Cancer;Chronic Liver Disease and Cirrhosis;Clinical Research;Cost Effectiveness Research;Digestive Diseases;Health Services;Liver Cancer;Liver Disease;Organ Transplantation;Rare Diseases;Transplantation

ORG_CITY: SAINT LOUIS

ORG_DEPT: SURGERY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: NARRATIVE This clinical trial will demonstrate the safety and feasibility of transplanting previously discarded sub-optimal livers after improving the liver using a machine perfusion. This new method will increase the number of transplantable livers and help to reduce organ shortage. This study will benefit all patients awaiting life-saving liver transplantation.

PI_NAMEs: CHAPMAN, WILLIAM C (contact);PARK, YIKYUNG

PROGRAM_OFFICER_NAME: SHERKER, AVERELL H

PROJECT_TERMS: Address;Affect;American;arm;Biliary;Blood;Body Temperature;Case Report Form;Clinical Trials;Colorectal;Communities;conditioning;cost;cost-effectiveness evaluation;Data;Death Rate;Dialysis procedure;Donor person;end stage liver disease;endoplasmic reticulum stress;ethnic diversity;experience;FDA approved;Functional disorder;Funding;Goals;graft function;Graft Survival;Health Care Costs;health care service utilization;hemodynamics;hepatocellular injury;Improve Access;improved;Infrastructure;Infusion Pumps;innovation;Intrahepatic Cholangiocarcinoma;Kidney Failure;Knowledge;Life;Liver;Liver diseases;Liver Dysfunction;liver function;liver transplantation;Malignant neoplasm of liver;Manuals;Mediating;Metabolic;Metastatic Neoplasm to the Liver;Methods;mitochondrial dysfunction;Modeling;Monitor;mortality risk;Multicenter Trials;Nutrient;operation;Operative Surgical Procedures;Organ;organ procurement transplantation network;Organ Procurements;Orphan;Outcome;Patients;Perfusion;Pharmaceutical Preparations;Phase;phase I trial;Phenotype;post-transplant;Primary carcinoma of the liver cells;primary outcome;Probability;Protocols documentation;Quality of life;racial diversity;Reporting;Research Design;retransplantation;Safety;safety and feasibility;secondary outcome;Site;Societies;Solid;Surgeon;Techniques;Testing;transplant centers;Transplant Surgeon;Transplantation;Uncertainty;United States Health Resources and Services Administration;usability;Waiting Lists

PROJECT_TITLE: Transplantation of Discarded Livers Following Normothermic Machine Perfusion: A Multicenter RESTORE Trial


ADMINISTERING_IC: DP

IC_NAME: NATIONAL CENTER FOR CHRONIC DISEASE PREVENTION AND HEALTH PROMOTION

ORG_CITY: FRANKFORT

ORG_NAME: KY ST CABINET/HEALTH/FAMILY SERVICES

ORG_STATE: KY

PHR: Project Narrative The Kentucky Department for Public Health (KDPH) is seeking to conduct on-going core PRAMS surveillance among women with a recent live birth. The KDPH will conduct PRAMS surveillance according to the CDC approved PRAMS protocols and implement survey supplements to respond to emerging issues when needed.

PI_NAMEs: JEWELL, TRACEY DANIELLE (contact)

PROJECT_TITLE: DP21-001 Kentucky Pregnancy Risk Assessment Monitoring SystemApplication for Core PRAMS funding RFA-DP-21-001


ORG_CITY: LINCOLN

ORG_NAME: NEBRASKA ST DEPT OF HEALTH & HUMAN SERVS

ORG_STATE: NE

PHR: Project Narrative Nebraska Pregnancy Risk Assessment Monitoring System (NE PRAMS) data is utilized by the Nebraska Department of Health and Human Services (NDHHS) Maternal and Child Health (MCH) programs and other state public health programs as a source of accurate information on state-specific, population-based data on maternal attitudes and experiences before, during, and shortly after pregnancy. NE PRAMS is currently the only readily-accessible source for population-level data on important issues such as pregnancy intendedness, reasons for patterns of prenatal care use, nutritional status of the mother, preconception health, and for postnatal behaviors such as depression, infant sleep position, and breastfeeding. State progra ms, local health departments, and community health organizations across the state that focus on maternal and child health issues have come to rely on PRAMS data to help identify, address, monitor, and evaluate both emerging and previously identified problems.

PI_NAMEs: SEVERE-OFORAH, JENNIFER  (contact)

PROJECT_TITLE: DP21-001 Nebraska Pregnancy Risk Assessment Monitoring System


ORG_CITY: JUNEAU

ORG_NAME: ALASKA STATE DEPARTMENT OF HLTH-SOC SVCS

ORG_STATE: AK

PHR: Project Narrative PRAMS is relevant to public health through its standardized collection of population-based data on maternal and infant health issues specific to Alaska. PRAMS provides self-reported maternal and infant health behavioral data that adds to outcome information gleaned from birth or hospital records that is helpful to program planning and evaluation. The standardized PRAMS protocol and methodology across states adds to the nationwide picture of maternal and child health status.

PI_NAMEs: PERHAM-HESTER, KATHERINE A (contact)

PROJECT_TITLE: DP21-001 Alaska Pregnancy Risk Assessment Monitoring System (PRAMS)


ORG_CITY: AUSTIN

ORG_NAME: TEXAS STATE DEPT OF HEALTH SERVICES

ORG_STATE: TX

PHR: Project Narrative In Texas, the Pregnancy Risk Assessment Monitoring System (PRAMS) provides the most comprehensive population-based data on maternal health during and after pregnancy. The proposed Texas PRAMS project will ensure that PRAMS data are used to inform, develop, and drive policies and programs to improve the health of mothers and babies.

PI_NAMEs: DELLA GROTTA, AMANDA  (contact)

PROJECT_TITLE: DP21-001Texas Pregnancy Risk Assessment Monitoring System (TX PRAMS)


ORG_CITY: CHEYENNE

ORG_NAME: WYOMING STATE DEPARTMENT OF HEALTH

ORG_STATE: WY

PHR: WY PRAMS PROJECT NARRATIVE See document entitled WY PRAMS PROJECT NARRATIVE 2021 in “Other Attachments.”

PI_NAMEs: GRANDPRE, JOSEPH  (contact)

PROJECT_TITLE: DP21-001 Wyoming PRAMS


ORG_CITY: TUMWATER

ORG_NAME: WASHINGTON STATE DEPARTMENT OF HEALTH

ORG_STATE: WA

PHR: Washington State PRAMS Component A [Core Surveillance] Grant 2021 Project Narrative The overall goal of Washington Pregnancy Risk Assessment Monitoring System (PRAMS) is to provide data that will influence program strategies, and policies that impact the health of women, infants and families in Washington State. The PRAMS survey provides a unique source of data on the behaviors and experiences of women before, during and just after delivery that is not available from any other source at the state level. This purpose of this proposal is to continue the PRAMs survey in Washington State. Approximately 2,000 Washington resident mothers per year are drawn from birth certificate data using a stratified random selection based on race/ethnicity. With a response rate of 55%, we are expecting that 1,100 women will participate in the survey. The data collection method for Washington PRAMS will involves a statewide mailing of the questionnaire with either a telephone or web-based survey as follow-up for non-responders. Completed surveys are cleaned by CDC, linked to the annual birth certificate file and weighted for non-response, an analytic file is sent to Washington PRAMS. Once Washington State receives the final analytic file from CDC we will analyze, interpret, and disseminate PRAMS data. The Washington State PRAMS project will utilize PRAMS data to plan and monitor programs and policies aimed at reducing health problems among mothers and infants.

PI_NAMEs: SKILES, MARTHA  (contact)

PROJECT_TITLE: RFA-DP-22-001 DP006601 Component A - Core Surveillance - Washington Pregnancy Risk Assessment Monitoring System (PRAMS) RFA-DP-16-001


NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Brain Disorders;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Health Services;Infectious Diseases;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric;Prevention;Primary Health Care;Social Determinants of Health

ORG_CITY: Canton

ORG_NAME: HARVARD PILGRIM HEALTH CARE, INC.

ORG_STATE: MA

PHR: PROJECT NARRATIVE  While several studies have noted substantial variations in the generosity of benefit coverage required by state autism insurance mandates, there is little evidence on how the effects of insurance mandates vary by the generosity. This proposed study aims to fill the evidence gap by identifying which specific mandate policy features matter most for improving health care for children with autism. The study findings have the potential to inform policymaking on expanding insurance benefits and closing coverage gaps for children with ASD, and the findings will also be relevant to broader debates around optimal design of essential health benefits, a topic of great interest to policymakers and researchers, especially in the past decade.

PI_NAMEs: YU, HAO  (contact)

PROGRAM_OFFICER_NAME: HUMENSKY, JENNIFER L

PROJECT_TERMS: Adopted;Affect;Age;age group;aged;autism spectrum disorder;autistic children;Behavior Therapy;Behavioral;Caring;Child;Child health care;Complex;COVID-19;COVID-19 pandemic;Data;Decision Making;design;developmental disease;District of Columbia;Exclusion;fighting;Goals;Health;Health Benefit;health care availability;health care cost/financing;health care service utilization;Health Insurance;Health system;Healthcare;Healthcare Systems;Home;improved;Individual;Inpatients;Insurance;Insurance Benefits;Insurance Carriers;insurance claims;Insurance Coverage;interest;knowledge base;Medical;medical specialties;meetings;Mental Health Services;Methods;Outpatients;pandemic disease;Parents;payment;Pharmacy facility;Policies;Policy Maker;Policy Making;Prevalence;Privatization;Public Health;Quasi-experiment;Reporting;Research Personnel;response;service utilization;Services;Statutes and Laws;Structure;Surveys;Tennessee;Time;Variant;Vulnerable Populations

PROJECT_TITLE: Insurance Mandate Generosity, COVID-19, and Health Care for Children with Autism

STUDY_SECTION: SERV

STUDY_SECTION_NAME: Mental Health Services Study Section[SERV]


ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: PROJECT NARRATIVE/RELEVANCE To reduce the impact of cancer on people by uniting a broad community of scientists and clinicians from many disciplines, committed to discovering, validating and disseminating effective strategies for the prevention and treatment of cancer.

PI_NAMEs: GALANIS, EVANTHIA ;HAHN, OLWEN ;PIANTADOSI, STEVEN  (contact)

PROGRAM_OFFICER_NAME: MOONEY, MARGARET M

PROJECT_TERMS: Address;Adolescent and Young Adult;Adult;Behavior;Biological;Breast;cancer clinical trial;Cancer Control;Cancer Patient;cancer prevention;cancer therapy;Central Nervous System;Characteristics;Clinical;clinical practice;Clinical Research;Clinical Trials;Clinical Trials Cooperative Group;Collaborations;Communities;Community Clinical Oncology Program;community setting;Consensus;control trial;Data;Data Analyses;Data Collection;data sharing;design;Discipline;Disease;Disease Resistance;DNA;Drug Combinations;effective therapy;Elderly;Electronic Health Record;Evaluation;experience;Funding;gastrointestinal;Genitourinary system;Germ Lines;Hematologic Neoplasms;improved;Infrastructure;innovation;Institution;Lead;Leadership;Malignant Neoplasms;Medidata;member;Methods;Mission;Molecular;Molecular Analysis;multidisciplinary;multimodality;National Clinical Trials Network;New Agents;novel strategies;Oncology;operation;participant enrollment;Pathogenesis;patient engagement;Patient-Focused Outcomes;Patients;Persons;prevent;Prevention strategy;Prevention trial;Principal Investigator;Process;programs;prospective;rare cancer;Recording of previous events;Regimen;Reporting;Research;Research Design;Research Personnel;Resistance;Resources;respiratory;response;Role;Scientist;Special Populations Research;Testing;therapy resistant;Translational Research;treatment trial;tumor;Underrepresented Minority;Validation;Variant;Vision;Work

PROJECT_TITLE: Alliance for Clinical Trials in Oncology Operations Center


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Palliative Care

PHR: The Project Narrative has been addressed in the Overall Component per the RFA

PI_NAMEs: PIANTADOSI, STEVEN  (contact)

PROJECT_TERMS: Academic Medical Centers;Address;American College of Surgeons;American College of Surgeons Oncology Group;Cancer and Leukemia Group B;Clinical Research;Clinical Trials;Collaborations;Community Clinical Oncology Program;conflict resolution;Decision Making;design;Development;Effectiveness;Ensure;Environment;Funding;Goals;health care delivery;Infrastructure;innovation;Institution;Leadership;Malignant Neoplasms;meetings;member;North Central Cancer Treatment Group;Oncology;operation;Operative Surgical Procedures;organizational structure;Policies;Positioning Attribute;Principal Investigator;Procedures;Process;Productivity;programs;Research;Research Personnel;Research Priority;response;rural setting;Structure;success;symptom management;System;Time;Translational Research;treatment group;urban setting

PROJECT_TITLE: Administrative Core


ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: NARRATIVE A major roadblock to rational HIV-1 vaccine design is the lack of a suitable primate model where the induction of broadly neutralizing antibodies (bNAbs) can be achieved in a consistent and reproducible manner and the molecular events responsible for bNAb elicitation deciphered. This HIVRAD application proposes a novel means to overcome this roadblock by using SHIVs as immunogens and new B cell analytics to elucidate Env-Ab co- evolutionary pathways, leading to new strategies for germline-targeted, B cell lineage-based vaccine design.

PI_NAMEs: SHAW, GEORGE M (contact)

PROGRAM_OFFICER_NAME: CHAKRABARTI, BIMAL KUMAR

PROJECT_TERMS: Address;Affinity;Amino Acid Substitution;Animals;Antibodies;Antibody Affinity;Antibody Response;Antigen Receptors;Antigens;Apical;Autologous;Award;B cell differentiation;B-Cell Antigen Receptor;B-Lymphocytes;Binding;Binding Sites;Bioinformatics;Biological;Biophysics;Cell Lineage;Chemicals;Chronic;clinically relevant;design;Development;env Gene Products;Epitopes;Event;Exposure to;Foundations;Genes;Germ Cells;Germ Lines;Goals;Grant;HIV-1;HIV-1 vaccine;Human;Humoral Immunities;Immunization;Immunogenetics;Immunologics;Infection;insertion/deletion mutation;Knock-in Mouse;Laboratories;Macaca mulatta;Mannose;Memory B-Lymphocyte;Modeling;Molecular;Monkeys;Monoclonal Antibodies;Mus;Mutagenesis;neutralizing antibody;novel;Pathway interactions;Pattern;Peptides;Plasma Cells;Polysaccharides;Prevalence;Primates;Process;Regimen;Reproducibility;Research;Research Project Grants;response;Role;Science;Scientific Advances and Accomplishments;simian human immunodeficiency virus;Specificity;statistics;Structure of germinal center of lymph node;Testing;Time;transmission process;Vaccination;Vaccine Design;vaccine effectiveness;Vaccine Research;Vaccines;Viral;Virus;Virus Diseases

PROJECT_TITLE: SHIV Env-antibody coevolution as a molecular guide to HIV-1 V3 glycan targeted vaccine design


NIH_SPENDING_CATS: Biotechnology;HIV/AIDS;Immunization;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

PROJECT_TERMS: Accounting;Antibodies;Award;Communication;data sharing;Dedications;Ensure;experience;Funding;Goals;Guidelines;HIV-1;Human Resources;IACUC;Information Technology;Infrastructure;Institution;Lead;Leadership;Measures;meetings;Molecular;Monitor;Occupational activity of managing finances;Pennsylvania;Polysaccharides;programs;Reporting;Research;Resources;Science;simian human immunodeficiency virus;Universities;Vaccine Design;Work

PROJECT_TITLE: Administration


NIH_SPENDING_CATS: Biotechnology;Genetics;HIV/AIDS;Immunization;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

PI_NAMEs: HAHN, BEATRICE H (contact)

PROJECT_TERMS: Acceleration;Affinity;Animals;Antibodies;Antigen Receptors;Antigens;Appearance;arms race;B-Cell Antigen Receptor;B-Lymphocytes;Base Sequence;Bioinformatics;Biological Assay;Blood;Cell Separation;Chemicals;Chronic;CMV promoter;Collaborations;cross reactivity;Data;Data Set;Databases;design;Development;DNA Sequencing Facility;env Genes;Epitopes;Escape Mutant;Evolution;Exposure to;Frequencies;Gene Family;Gene Rearrangement;Genes;genome sequencing;Germ Lines;Glycoproteins;glycosylation;Goals;HIV;HIV vaccine;HIV-1;HIV-1 vaccine;Human;Immunization;Immunize;Immunogenetics;Immunoglobulin Genes;Immunoglobulins;improved;Individual;Knock-in Mouse;Length;Libraries;Ligation;Light;Macaca;Macaca mulatta;Mannose;Maps;Mediating;Memory B-Lymphocyte;Molecular;Monitor;Mutagenesis;Mutation;nanoparticle;neutralizing antibody;Pathway interactions;Pattern;Peripheral Blood Mononuclear Cell;Phylogenetic Analysis;Plasma;Polysaccharides;pressure;Process;Production;rational design;Reproducibility;response;Rhesus;RNA;Role;Sampling;Satellite Viruses;Sequence Alignment;Series;Services;simian human immunodeficiency virus;SIV;Somatic Mutation;statistics;success;Testing;Time;Transcript;Translating;translation to humans;Vaccinated;Vaccination;Vaccine Design;Vaccine Research;Vaccines;Variant;Virion;virology;Virus;Virus Diseases;virus envelope;Work;working group

PROJECT_TITLE: Virus and Antibody Gene Sequencing Core


ADMINISTERING_IC: DC

ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Hearing Loss;Neurosciences;Pediatric

ORG_CITY: CINCINNATI

ORG_NAME: UNIVERSITY OF CINCINNATI

ORG_STATE: OH

PHR: Children and young adults with clinically normal hearing often leave audiology clinics with no diagnosis to explain the difficulty they experience listening in noise. This study will provide valuable insight concerning the role of extended high-frequency hearing loss in the auditory challenges these individuals experience in their daily communications.

PI_NAMEs: MOTLAGH ZADEH, LINA  (contact)

PROGRAM_OFFICER_NAME: KING, KELLY ANNE

PROJECT_TERMS: 14 year old;Address;Adult;Affect;Aging;Audiology;Auditory;Auditory Perception;Auditory Threshold;Behavioral;Cell Physiology;Child;Clinic;Clinical;Cochlea;Communication;Control Groups;Cueing for speech;Cues;Data;Detection;Diagnosis;Digit structure;Early Intervention;Environment;Evaluation;experience;experimental study;Foundations;Frequencies;genetic variant;Goals;Hearing;hearing impairment;Hearing Tests;High-Frequency Hearing Loss;Impairment;Individual;insight;Life;Measurement;Measures;multitalker environment;neglect;Noise;noise perception;noise trauma;normal hearing;Otitis Media;otoacoustic emission;ototoxicity;Outcome;Outer Hair Cells;Parents;Pathology;Patient Self-Report;Performance;Persons;Play;Predictive Factor;Predisposition;pressure;preventive intervention;Questionnaires;Recording of previous events;recruit;Reporting;Role;sound;sound frequency;Space Perception;Speech;speech in noise;Speech Perception;speech recognition;Stimulus;Testing;Tube;Virus Diseases;young adult;Youth

PROJECT_TITLE: Investigating the contribution of extended high-frequency hearing loss to poor speech-in-noise perception in clinically normal hearing children and young adults.

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Orphan Drug;Rare Diseases

PROJECT_TERMS: Address;Area;Basic Science;Biological Markers;Clinical;Clinical Investigator;Clinical Research;clinical translation;Clinical Trials;Collaborations;Combined Modality Therapy;Committee Members;Complex;design;Development;Discipline;Disease;early phase trial;Environment;Fostering;Funding Agency;Goals;imaging study;improved;Industry;industry partner;Information Systems;Infrastructure;innovation;inter-institutional;Investigational Therapies;Knowledge;Leadership;Malignant Neoplasms;meetings;Mission;multidisciplinary;New Drug Approvals;new therapeutic target;next generation;Oncology;operation;Patients;performance site;Pharmaceutical Preparations;Principal Investigator;Process;Productivity;Program Development;programs;rare cancer;Research;Research Design;Research Personnel;Resources;response;Science;Secure;Special Population;Special Populations Research;Structure;Therapeutic Trials;timeline;tool;Training;Translational Research;translational scientist;trial design;Update;Work

PROJECT_TITLE: Clinical Trials Development Core


PI_NAMEs: WAGH, KSHITIJ  (contact)

PROJECT_TERMS: Acceleration;Affinity;Antibodies;Antibody Response;Antigens;B cell repertoire;B-Lymphocytes;Bioinformatics;Biological;Biological Models;Biological Phenomena;Biology;Chronic;Collaborations;Complement;Complex;computational pipelines;Data;design;Development;Epitopes;Evolution;Foundations;Germ Lines;Glycoproteins;Goals;Helper-Inducer T-Lymphocyte;HIV Infections;HIV-1;Human;Immunogenetics;Immunoglobulin Somatic Hypermutation;in vivo;in vivo Model;Individual;Infection;iterative design;longitudinal analysis;Macaca mulatta;Modeling;Molecular;neutralizing antibody;novel;Pathway Analysis;Pathway interactions;Pattern;Polysaccharides;pressure;Prevalence;prevent;protective efficacy;Publishing;Reproducibility;Resistance;Rhesus;Series;simian human immunodeficiency virus;Statistical Models;statistics;Structure of germinal center of lymph node;System;T-Lymphocyte;Testing;transcriptomics;Translating;Vaccinated;Vaccination;Vaccine Design;vaccine efficacy;vaccine evaluation;Vaccines;Variant;Viral

PROJECT_TITLE: Bioinformatics and Statistics


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Digestive Diseases;Genetics;Human Genome;Immunotherapy;Microbiome;Natural Products;Orphan Drug;Pancreatic Cancer;Rare Diseases

ORG_CITY: TORONTO

ORG_COUNTRY: CANADA

ORG_FIPS: CA

ORG_NAME: UNIVERSITY HEALTH NETWORK

ORG_STATE: ON

ORG_ZIPCODE: M5G 2C4

PHR: PROJECT NARRATIVE Pancreatic cancer is one of the most lethal forms of cancer with 5-year survival rates of 7%. Our preliminary data suggest a key factor driving pancreatic tumor progression is the profound immune suppression in tumors driven by gut micro biome-produced metabolites. In this application we predict interfering with this gut-tumor axis will cause the tumors to become inflamed reducing growth and spread rendering pancreatic cancer sensitive to therapy. This project has the potential to completely change our understanding of the microbiome and how it influences immunity. Likewise, lessons learned from this project will enhance our understanding of tumor- gut interactions that will provide new prognostic tools and therapeutic targets.

PI_NAMEs: MCGAHA, TRACY L (contact)

PROGRAM_OFFICER_NAME: RASOOLY, AVRAHAM

PROJECT_TERMS: Aryl Hydrocarbon Receptor;Automobile Driving;Biological;Cancer Etiology;CD8-Positive T-Lymphocytes;Cessation of life;checkpoint therapy;chemotherapy;Clinical;Data;Disease;Environment;Exhibits;experimental study;Fostering;Functional disorder;gemcitabine;Gene Expression Profile;Germ-Free;Goals;Growth;gut colonization;gut microbiome;gut microbiota;Human;Immune;immune cell infiltrate;Immune System Diseases;Immunity;Immunooncology;immunoregulation;Immunosuppression;Immunotherapy;improved;Indoles;Infiltration;Inflammatory;inhibitor;inhibitor therapy;insight;Investigation;KPC model;Lactobacillus;Link;Lytic;Macrophage;Malignant neoplasm of pancreas;Malignant Neoplasms;Mediating;Metabolic;microbial;microbial composition;microbiome;microbiome alteration;microbiota;mouse model;Mus;Myelogenous;Nature;Neoplasm Metastasis;new therapeutic target;North America;novel;Operative Surgical Procedures;Outcome;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma model;pancreatic neoplasm;Pathway interactions;Patients;Peripheral Blood Mononuclear Cell;Phenotype;Play;Population;predict clinical outcome;Production;prognostic tool;Receptor Activation;Refractory;Resistance;response;Role;sensor;Severity of illness;Shapes;standard of care;Survival Rate;T cell response;T-Lymphocyte;Testing;Therapeutic Intervention;therapeutic target;Time;treatment response;Tryptophan;tumor;tumor growth;tumor microbiome;tumor microenvironment;tumor progression

PROJECT_TITLE: Mechanistic investigations of microbiome-driven aryl hydrocarbon receptor activity and macrophage function in pancreatic cancer.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-M(08)F]


NIH_SPENDING_CATS: Cancer;Genetics;Human Genome;Precision Medicine;Prostate Cancer;Urologic Diseases

PHR: PROJECT NARRATIVE  One of the major barriers to effective treatment using PARP inhibitor is how to select patients who most likely benefit from PARP inhibition. In this project, we will determine whether loss of MMS22L can predict response to PARP inhibitor in prostate cancer.

PI_NAMEs: JIA, LI  (contact)

PROGRAM_OFFICER_NAME: COVELL, DAVID G

PROJECT_TERMS: abiraterone;androgen independent prostate cancer;Androgen Receptor;Armenia;Biological Markers;BRCA1 gene;BRCA1 Mutation;BRCA2 gene;BRCA2 Mutation;cancer cell;Cancer Patient;Cell Death;Cells;Cessation of life;Clinical;Clinical Trials;Complex;CRISPR screen;CRISPR/Cas technology;Defect;Disease;DNA Damage;DNA Double Strand Break;DNA lesion;DNA Repair;DNA replication fork;DNA Sequence Alteration;E2F transcription factors;effective therapy;Eligibility Determination;enzalutamide;Enzymes;Event;Filament;Future;G2/M Checkpoint Pathway;gene discovery;Gene Expression;gene repair;Generations;Genes;Genetic;genome-wide;Genomics;Goals;homologous recombination;homologous recombination deficiency;improved;inhibitor;Life;Malignant neoplasm of prostate;Measures;Mediating;men;Mitotic;Molecular Target;Mutation;neoplastic cell;new therapeutic target;novel;Oncology;Outcome;Pathway interactions;Patient Selection;Patients;personalized medicine;Poly(ADP-ribose) Polymerase Inhibitor;Poly(ADP-ribose) Polymerases;pre-clinical;predicting response;prevent;prostate cancer cell;prostate cancer model;Prostatic Neoplasms;Proteins;RB1 gene;Receptor Signaling;recombinational repair;Research;Resistance;Resolution;response;screening;Site;targeted treatment;Testing;Therapeutic;Time;TP53 gene;tumor;United States;Up-Regulation;Work

PROJECT_TITLE: MMS22L loss and PARP inhibition in prostate cancer

STUDY_SECTION: MCTB

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics B Study Section[MCTB]


ORG_CITY: LUBBOCK

ORG_DEPT: PHYSIOLOGY

ORG_NAME: TEXAS TECH UNIVERSITY HEALTH SCIS CENTER

PHR: Project narrative Because K+ selective ion channels are essential regulators of cell excitability, their dysfunction underlies a myriad of human pathological conditions that make them excellent targets for drugs to treat very diverse diseases, such as: LQT syndrome, arrhythmia, epilepsy, autoimmune diseases and diabetes. It follows that understanding the function-structure correlations of K+ channels at atomic resolution will pave the road to develop highly-specific therapeutic drugs to correct channelopathies. The central tenet of this grant application is how the structure determine the function of ion channel and how this relationship is influenced by the cell membrane lipid composition.

PI_NAMEs: CUELLO, LUIS GONZALO (contact)

PROGRAM_OFFICER_NAME: NIE, ZHONGZHEN

PROJECT_TERMS: Achievement;Affinity;Alkali Metals;Applications Grants;Arrhythmia;Autoimmune Diabetes;Autoimmune Diseases;Behavior;Binding Sites;Calorimetry;Cell membrane;Cells;Consumption;Coupling;design;Development;Disease;Disulfides;Drug Targeting;Electrophysiology (science);Engineering;Epilepsy;Escherichia coli;Eukaryotic Cell;Functional disorder;Funding;Human;Individual;Ion Channel;Ions;Lipid Bilayers;Lipids;Measures;Membrane Lipids;Metal Ion Binding;Methodology;Molecular Conformation;novel;novel therapeutics;overexpression;Pathologic;Pharmaceutical Preparations;Phospholipids;Physiological;Physiology;Potassium Channel;Regulation;Resolution;scaffold;Structure;Syndrome;Therapeutic;Thermodynamics;Thick;Time;Titrations;United States National Institutes of Health;Work

PROJECT_TITLE: A comprehensive thermodynamic and structural characterization of ion channel function and its regulation by the lipid bilayer composition


PROJECT_TERMS: Affinity;Animals;Antibodies;Antibody Affinity;Antibody Response;Antigens;Apical;arm;Autologous;B-Lymphocytes;Binding Sites;Biological;Data;Data Set;design;Development;Epitopes;Frequencies;Germ Lines;Glycopeptides;Goals;HIV-1;HIV-1 vaccine;Human;Immunization;Immunize;immunogenicity;Immunologics;Infection;innovation;Length;Link;Macaca mulatta;Mannose;Modeling;Molecular;Molecular Analysis;Monoclonal Antibodies;Mutation;nanoparticle delivery;neutralizing antibody;nonhuman primate;novel;Pathway interactions;Peptides;Polysaccharides;Prevalence;Primates;Process;Program Research Project Grants;Reproducibility;response;Reverse engineering;Rhesus;Scheme;Scientific Advances and Accomplishments;simian human immunodeficiency virus;Specificity;Speed;Structure;Testing;transmission process;Vaccination;Vaccine Design;Vaccine Research;vaccine trial;Virus;Virus Diseases;Work

PROJECT_TITLE: Env-Ab coevolution in SHIV infected RMs leading to V3 glycan bNAbs


NIH_SPENDING_CATS: Bioengineering;Brain Cancer;Brain Disorders;Cancer;Genetics;Nanotechnology;Neurosciences;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: NEW HAVEN

ORG_DEPT: NEUROSURGERY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Relevance to public health: Glioblastoma is the most common primary malignant brain tumors in adults. More than 12,000 new cases are diagnosed in the United States each year. This research project will result in new approaches for improved treatment of patients with this disease.

PI_NAMEs: ZHOU, JIANGBING  (contact)

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: Acute Promyelocytic Leukemia;Adult;Bioinformatics;Biology;Brain;Brain Neoplasms;Candidate Disease Gene;candidate identification;Cell Differentiation process;chemotherapeutic agent;Collection;CRISPR/Cas technology;Cytotoxic agent;Databases;Development;Diagnosis;Differentiation Therapy;Disease;effective therapy;Effectiveness;Encapsulated;Genes;Genetic;genome-wide;Glioblastoma;Goals;Hydrogels;improved;Iodides;Lead;lead candidate;Liposomes;Malignant neoplasm of brain;Malignant Neoplasms;molecular marker;Molecular Target;nanoparticle;nestin protein;Neurons;novel;novel strategies;Operative Surgical Procedures;patient derived xenograft model;Patients;pharmacologic;Predisposition;Prognosis;Property;Public Health;Radiation therapy;Regimen;Regulation;Research;Research Project Grants;Resistance;RNA interference screen;single-cell RNA sequencing;stem cell differentiation;stem cells;success;targeted delivery;temozolomide;Therapeutic;therapeutic evaluation;therapeutic target;Toxic effect;Tretinoin;Tumorigenicity;United States;Validation;Work

PROJECT_TITLE: Elucidate genetic regulation of GBM differentiation

STUDY_SECTION: DT

STUDY_SECTION_NAME: Developmental Therapeutics Study Section[DT]


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities

PROJECT_TERMS: Address;Adolescent and young adult cancer patients;American College of Surgeons Oncology Group;Cancer and Leukemia Group B;Clinical;Clinical Research;Clinical Trials;Community Clinical Oncology Program;design;Education;Effectiveness;Enrollment;Ensure;Fostering;Goals;Healthcare Systems;Infrastructure;Institution;Lead;Leadership;Malignant Neoplasms;member;North Central Cancer Treatment Group;older patient;Oncology;operation;patient population;Patients;Policies;Principal Investigator;programs;rare cancer;recruit;Research;Research Personnel;Research Priority;Services;Site;Surgeon;translational cancer research;Translational Research;translational scientist;U-Series Cooperative Agreements;Work

PROJECT_TITLE: Member Site Core


PI_NAMEs: KELSOE, GARNETT H (contact)

PROJECT_TERMS: Adjuvant;Affect;Affinity;Antibodies;Antibody Formation;Antibody Response;Antigen Receptors;Antigens;Appearance;aspirate;Autologous;B-Cell Activation;B-Lymphocytes;Binding;Blood;Blood specimen;Cell Compartmentation;Cell Separation;Cells;Chronic;cohort;Cohort Studies;Development;Engineering;Environment;Exposure to;Genes;Genetic Transcription;Germ Lines;Helper-Inducer T-Lymphocyte;HIV-1;Immunization;Immunize;Immunologics;Individual;Infection;Knock-in;Knock-in Mouse;Label;Link;longitudinal analysis;lymph nodes;Lymphocyte;Macaca mulatta;Maps;Measures;Memory B-Lymphocyte;Molecular;Mus;mutant;Mutation;neutralizing antibody;Phenotype;Plasma Cells;Play;Polysaccharides;Probability;Proliferating;response;Role;Sampling;Secondary to;Serology;Serum;simian human immunodeficiency virus;single cell analysis;Specificity;Structure of germinal center of lymph node;T cell receptor repertoire sequencing;T-cell receptor repertoire;T-Lymphocyte;Tamoxifen;transcriptome;transcriptome sequencing;Vaccine Antigen;Vaccine Design;vaccine efficacy;Vaccines;Variant

PROJECT_TITLE: Optimizing Humoral Responses to HIV-1 Env Vaccine Antigens


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Prevention;Social Determinants of Health

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

ORG_STATE: NY

PHR: PROJECT NARRATIVE: This proposal will be the first to simultaneously examine trajectories, and modifiable risk factors, of structural and functional brain decline, gait decline, and cognitive decline in aging and pre- dementia. This proposal has the potential to directly inform the development of targeted, and appropriately sequenced, interventions for maintaining gait and cognition in aging and pre-dementia.

PI_NAMEs: BLUMEN, HELENA M;MILMAN, SOFIYA  (contact)

PROGRAM_OFFICER_NAME: ST  HILLAIRE-CLARKE, CORYSE

PROJECT_TERMS: Acceleration;Address;Affect;Age;age related;age-related disease;Aging;aging brain;aging related;Alzheimer's disease related dementia;Area;Atrophic;Biological;Brain;Caregivers;Caring;Clinical;Cognition;Cognitive;cognitive testing;Communities;cost effective;cost estimate;Cues;Data;Dementia;dementia risk;Development;Direct Costs;disability;effective therapy;Emergency Situation;Enrollment;executive function;fall injury;falls;Family;Family member;follower of religion Jewish;Friends;Functional Magnetic Resonance Imaging;Future;Gait;Gait abnormality;Gait speed;Genetic;gray matter;Health Care Costs;healthy aging;Human;Image;Imagery;Impaired cognition;Individual;informal care;innovation;instrument;Insula of Reil;Intervention;Left;Link;Locomotion;Longevity;Magnetic Resonance Imaging;Modeling;modifiable risk;Motor;MRI Scans;neural;neuroimaging;offspring;older adult;Outcome;Parents;Participant;Pathway interactions;Persons;Prefrontal Cortex;processing speed;Quality of life;Research;Rest;Risk;Risk Factors;Risk Reduction;Role;Sensory;social contact;Social Network;social relationships;Social support;Societies;Stress Tests;Syndrome;Techniques;Testing;therapy development;Thick;Trail Making Test;Visit;Walking;white matter;Woman;Work

PROJECT_TITLE: Trajectories and modifiable risk factors of brain, gait, and cognitive decline in aging and pre-dementia

STUDY_SECTION: ASG

STUDY_SECTION_NAME: Aging Systems and Geriatrics Study Section[ASG]


PI_NAMEs: WIEHE, KEVIN  (contact)

PROJECT_TERMS: Acceleration;Affinity;Animal Model;Animals;Antibodies;Antibody Response;Antigens;B cell repertoire;B-Lymphocytes;Back;Binding;Cell Lineage;Cell surface;Complex;design;Development;Engineering;Epitopes;Event;Evolution;feature detection;Genealogy;Germ Lines;Goals;high throughput screening;HIV;HIV vaccine;HIV-1;Human;humanized mouse;Immunization;Immunize;Immunogenetics;Immunoglobulin Somatic Hypermutation;Infection;Libraries;Macaca mulatta;Mammalian Cell;Modeling;Molecular;Monkeys;mouse model;Mus;Mutation;neutralizing antibody;novel;Pathway interactions;Polysaccharides;Primates;Recording of previous events;Regimen;response;Rhesus;simian human immunodeficiency virus;Site;Source;success;System;Testing;vaccination strategy;vaccine candidate;Vaccine Design;vaccine development;Vaccines;Variant;Viral;Work

PROJECT_TITLE: Immunogen design to elicit polyclonal bNAb responses to the V3 glycan supersite


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Drug Abuse (NIDA only);Neurosciences;Opioids;Substance Misuse

ORG_CITY: JACKSON

ORG_NAME: UNIVERSITY OF MISSISSIPPI MED CTR

ORG_STATE: MS

PHR: PROJECT NARRATIVE The increase in overdose-related deaths associated with the misuse of clinical opioids has prompted synthesis efforts geared towards designing safer opioids. Novel atypical opioid agonists have been developed that appear to have a favorable profile of behavioral effects, producing full analgesia with fewer unwanted side effects (e.g., respiratory depression, abuse liability); however, the mechanisms underlying the improved profile are not known. Our studies will determine the extent to which the desirable profiles of these agonists are due to low intrinsic efficacy at mu-opioid receptors or to preferential activation of one of the mu-opioid receptor’s signaling pathways.

PI_NAMEs: PHAM, LOC M (contact)

PROGRAM_OFFICER_NAME: FALCON-MORALES, EDGARDO

PROJECT_TERMS: Absence of pain sensation;abuse liability;Adverse effects;Agonist;Analgesics;Animal Model;antinociception;arrestin 2;behavior measurement;Behavioral;Biological Assay;Buprenorphine;Cessation of life;Clinical;comparative;Data;design;Development;Dose;drug discovery;efficacious treatment;Exhibits;Fentanyl;G-Protein Signaling Pathway;graduate school;GTP-Binding Proteins;Health Sciences;improved;In Vitro;in vivo;Investigation;Measures;Mediating;Medical center;Methodology;Mississippi;Morphine;mu opioid receptors;Neurosciences;Nociception;novel;Opioid;Opioid agonist;Overdose;Oxycodone;Pain;Pain management;Pathway interactions;Pharmaceutical Preparations;Positioning Attribute;pre-clinical;Pre-Clinical Model;programs;Published Comment;Publishing;Rattus;recruit;Reinforcement Schedule;relative effectiveness;Reporting;Respiration;respiratory;Safety;Self Administration;Series;side effect;Signal Pathway;Signaling Protein;stem;Stimulus;Temperature;Testing;Therapeutic;Therapeutic Effect;Training;Universities;Ventilatory Depression;warm temperature;Whole Body Plethysmography;Work

PROJECT_TITLE: Investigation of in vivo efficacy of G-protein biased mu opioid receptor agonists.