NIH_SPENDING_CATS: Autoimmune Disease;Celiac Disease;Clinical Research;Digestive Diseases;Nutrition;Pediatric

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: Project Narrative There is a strong medical need for a better diagnostic approach for celiac disease that accurately reflects the underlying pathogenesis and overcomes the limitations of small intestinal biopsy and antibodies to tissue- transglutaminase-2. This study will evaluate sensitivity of a novel ex vivo gluten challenge whole blood assay that is highly specific for celiac disease in adults treated with a gluten-free diet in children with celiac disease (both treated and untreated). Results of this study will guide protocol development for a multi-center clinical trial to determine the diagnostic accuracy of cytokine release following gluten challenge for diagnosis of celiac disease that may redefine celiac disease and revolutionize diagnosis.

PI_NAMEs: SILVESTER, JOCELYN ANNE (contact)

PROGRAM_OFFICER_NAME: SASLOWSKY, DAVID E

PROJECT_TERMS: 18 year old;Acute;adaptive immune response;Adult;Affect;Affinity;age difference;age group;Agreement;Antibodies;Antigens;Autoimmune Diseases;Binding;Biological Assay;Biopsy;Blood;CCL20 gene;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Celiac Disease;Cells;Chemiluminescence assay;chemokine;Child;Childhood;Chronic;clinical practice;cohort;Consumption;CXCL10 gene;CXCL9 gene;CXCR3 gene;cytokine;Data;Development;Diagnosis;Diagnostic;diagnostic accuracy;Diagnostic Procedure;diagnostic strategy;Diagnostic tests;dietary;Dose;Double-Blind Method;Eating;Evaluation;Event;Exposure to;Generations;Gluten;Gluten-free diet;Goals;Grant;Histology;HLA-DQ2;HLA-DQ8 antigen;Homing;IL17 gene;IL8 gene;Immune;Immune response;Immune System Diseases;improved;in vivo;Incubated;Individual;Ingestion;Intake;Interferon Type II;Interleukin-10;Interleukin-2;interleukin-22;intestinal villi;Laboratories;Measures;Medical;memory CD4 T lymphocyte;Methods;Mucous Membrane;Multi-Institutional Clinical Trial;noninvasive diagnosis;novel;Oral;Pathogenesis;Pathologic;Patients;Peptides;Plasma;Population;primary outcome;protocol development;Randomized, Controlled Trials;recruit;Research Project Grants;response;secondary analysis;Small Intestines;Specificity;Symptoms;T-Lymphocyte;Testing;Tissue Transglutaminase Antibodies;TNF gene;transglutaminase 2;Whole Blood

PROJECT_TITLE: Immune responses to ex vivo gluten challenge in children with celiac disease

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


ADMINISTERING_IC: AI

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF PHARMACY

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Assistive Technology;Biodefense and Related Countermeasures;Bioengineering;Emerging Infectious Diseases;Infectious Diseases;Rehabilitation

ORG_CITY: Columbus

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PHARMACOLOGY

ORG_FIPS: US

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative Methicillin-resistant Staphylococcus aureus is a leading cause of medical device infections and treatment failure is commonplace due to the production of bacterial biofilm and subsequent reduced antibiotic activity along with resistance development. Our experimental approach is to investigate the impact of a. a single dose dalbavancin in combination with a single dose of daptomycin b. this combination with addition of phage, in a two-compartment pharmacokinetic/pharmacodynamic biofilm model. This proposal will assess the potential for antibiotic dose-de- escalation in dalbavancin-daptomycin-phage treatment using pharmacokinetic parameters and without the emergence of resistance.

PI_NAMEs: KEBRIAEI, RAZI  (contact)

PROGRAM_OFFICER_NAME: XU, ZUOYU

PROJECT_TERMS: Anti-Bacterial Agents;Antibiotic Resistance;Antibiotic susceptibility;Antibiotic Therapy;Antibiotics;Antimicrobial Resistance;Area;Bacteremia;Bacterial Antibiotic Resistance;bacterial resistance;Bacteriophages;bone prosthesis;Culture Media;dalbavancin;Daptomycin;Data;Death Rate;Development;Devices;Disparate;Dose;Drug Kinetics;effective therapy;Endocarditis;Excision;Failure;Frequencies;Future;Generations;Genus staphylococcus;Growth;Health Care Costs;Human body;Immune system;implant material;improved;In Vitro;Infection;joint infection;Joint Prosthesis;Life;Measurement;Medical Device;methicillin resistant Staphylococcus aureus;Microbial Biofilms;Minimum Inhibitory Concentration measurement;Modeling;Monitor;Morbidity - disease rate;mortality;Multi-Drug Resistance;Multiple Bacterial Drug Resistance;novel therapeutics;Osteomyelitis;Outpatients;Patient Care;Penetration;pharmacodynamic model;Pharmacodynamics;Plasma;pre-clinical;Predisposition;preservation;Prevention;Production;Prosthesis;Recommendation;Regimen;Reporting;Research;Resistance;Resistance development;Sampling;Sepsis;standard of care;Staphylococcus aureus infection;Testing;Time;Treatment Failure;treatment optimization;Treatment Protocols;Vancomycin;Work

PROJECT_TITLE: In vitro Pharmacokinetic/pharmacodynamic models for dose de-escalation of antibiotics

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-M (81)]


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Cerebrovascular;Clinical Research;Congenital Structural Anomalies;Neurosciences;Pediatric;Stroke

ORG_CITY: HOUSTON

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: Project Narrative Although brain arteriovenous malformation (bAVM) is a high-risk factor for intracerebral hemorrhage, especially for young patients, the treatment options are severely limited. By the notion that endothelial-to-mesenchymal transition (EndMT) is a common feature in human bAVM, the current proposal will determine if EndMT can be a target to treat bAVMs using human bAVM tissues and cells. The proposal is relevant to the NIH's mission because the results of this study could lead to the development of therapeutic strategies for bAVM patients, subsequently preventing hemorrhagic stroke.

PI_NAMEs: CHEN, PENG ROC;KIM, EUNHEE  (contact)

PROGRAM_OFFICER_NAME: UTZ, URSULA

PROJECT_TERMS: Address;Animals;Arteries;Attenuated;biobank;Blood Vessels;brain arteriovenous malformations;brain endothelial cell;Brain hemorrhage;cadherin 5;Calpain;calpain inhibitor;Cardiac;Caspase;Cause of Death;CD44 gene;Cell Physiology;Cells;Cerebral hemisphere hemorrhage;Cessation of life;Characteristics;Data;Development;disability;DNA sequencing;Electrical Resistance;Endothelial Cells;Endothelium;Etiology;Excision;experience;experimental study;Family;Frequencies;Functional disorder;Genes;Genetic;Germ Lines;Goals;Grant;Hemorrhage;high risk;Human;human tissue;improved;In Vitro;Intercellular Junctions;KRAS2 gene;Life;Location;Measures;Mediating;Mesenchymal;Methods;migration;Mission;MMP9 gene;mouse model;Mus;mutant;Mutation;Mutation Detection;N-Cadherin;Neurofibrillary Tangles;Neurologic Deficit;new therapeutic target;novel;Operative Surgical Procedures;overexpression;Pathologic Neovascularization;Pathology;Patients;Pharmacological Treatment;Phenotype;Physiologic Neovascularization;pre-clinical;prevent;Process;Proliferating;prospective;Proteins;Proteomics;Radiation;Reporting;Risk;Risk Factors;Role;Rupture;Sampling;Small Interfering RNA;Somatic Mutation;Structure of parenchyma of lung;Testing;Therapeutic;therapeutic development;Therapeutic Embolization;Tissues;transcriptome sequencing;translational study;Tube;United States National Institutes of Health;Veins;VWF gene

PROJECT_TITLE: EndMT as a target to treat human brain arteriovenous malformations

STUDY_SECTION: BINP

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Digestive Diseases;Liver Disease

ORG_CITY: CHARLESTON

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: Project Narrative Although extensive research has focused on the molecular motor protein Myosin 5b in the intestinal epithelium, its role in the liver remains under explored. Recent studies implicate Myosin 5b in liver disorders but to date few studies have used animal models to investigate how Myosin 5b regulates liver function. This proposal seeks to address this gap in knowledge by identifying molecular mechanisms governing metabolic homeostasis in the liver.

PI_NAMEs: ENGEVIK, AMY C (contact)

PROJECT_TERMS: Address;Animal Model;Apical;apical membrane;base;Bile Acids;Bioenergetics;Biological Assay;Blood Circulation;Blood Glucose;blood glucose regulation;Carbohydrates;Cells;Cholestasis;comparison control;confocal imaging;Confocal Microscopy;Data;Defect;Diarrhea;Disease;Electron Microscopy;Enzymes;Epithelial Cells;Exhibits;experimental study;extracellular;F-Actin;Family;fatty acid oxidation;Fatty Acids;Frequencies;Funding;Future;Gastrointestinal tract structure;Generations;Genes;Genus Hippocampus;Germ Lines;Glucose;Glucose Transporter;glucose uptake;GLUT-2 protein;Glycogen;glycogen metabolism;Golgi Apparatus;Hepatocyte;Homeostasis;Human;Immobilization;In Vitro;in vivo;Individual;interest;intestinal epithelium;Intestines;Intracellular Transport;K-Series Research Career Programs;knockout animal;Knockout Mice;Knowledge;Link;lipid biosynthesis;lipid metabolism;Lipids;Liver;Liver diseases;liver function;Liver Glycogen;liver imaging;liver metabolism;Liver Mitochondria;Mentored Research Scientist Development Award;Mentors;Metabolic;Metabolic Pathway;Metabolism;Microvillus inclusion disease;Mitochondria;Molecular;Molecular Motors;Morphology;mouse model;Mus;Mutation;Myosin ATPase;National Institute of Diabetes and Digestive and Kidney Diseases;Nutrient;nutrient absorption;Organ;Organelles;Organoids;oxidation;Oxygen Consumption;Pathway interactions;peroxisome;Play;Positioning Attribute;Postdoctoral Fellow;prevent;Process;Production;Proteins;Regulation;Reporting;Research;Research Proposals;Research Technics;Resolution;Respiration;Role;Secure;Site;Surface;Testing;Tissues;trafficking;treadmill;Triglycerides;uptake;Very low density lipoprotein;Work

PROJECT_TITLE: Understanding the role of Myosin 5b in liver metabolism


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Hematology;Immunotherapy;Lymphatic Research;Lymphoma;Orphan Drug;Rare Diseases

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

ORG_STATE: NY

PHR: PROJECT NARRATIVE Human T-cell lymphotropic virus type 1 (HTLV-1) induced adult T-cell leukemia/lymphoma (ATLL) is a rare and fatal malignancy with limited therapeutic option. Our preliminary studies revealed that ATLL cells demonstrate a robust immune-suppression phenotype and there is a unique population of markedly expanded, phenotypically exhausted CD8+ T cells at the time of diagnosis. The objective of this study is to functionally characterize the suppressive activity of ATLL cells and define new immune correlates of favorable treatment outcomes in the context of the Belinostat/Zidovudine/IFN trial (NCT02737046).

PI_NAMEs: LAUVAU, GREGOIRE STEPHANE;YE, BIHUI HILDA (contact)

PROGRAM_OFFICER_NAME: WALLACE, TIFFANY A

PROJECT_TERMS: Adult T-Cell Leukemia/Lymphoma;Age;anti-PD-1;Anti-viral Agents;Antigen Presentation;B-Lymphocytes;BCL6 gene;biobank;Biological Assay;Biological Response Modifiers;cancer type;Caribbean region;CCL3 gene;CCL4 gene;CD28 gene;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Compartmentation;Cell Physiology;Cells;Cellular Assay;chemokine;chemotherapy;Clinical;clinical efficacy;Combination Drug Therapy;Combined Modality Therapy;CTLA4 gene;cytokine;Cytotoxic T-Lymphocytes;design;Development;Diagnosis;Diagnostic;Disease;Disease remission;effector T cell;exhaust;exhaustion;Exhibits;experience;Face;Flow Cytometry;FOXP3 gene;Goals;granulysin;Granzyme;Hematopoietic Neoplasms;high dimensionality;Histone Deacetylase Inhibitor;Human T-lymphotropic virus 1;IL2RA gene;Immigrant;Immune;Immune Evasion;immune function;Immune response;Immunity;Immunogenetics;immunogenic;Immunologic Surveillance;immunomodulatory therapies;Immunosuppression;Immunotherapy;improved;Interferons;Interleukin-2;Japan;Japanese;Latin American;Lymphoma cell;Malignant - descriptor;Malignant Neoplasms;Medical;Memory;Modeling;Molecular;Monoclonal Antibodies;Monoclonal Antibody Therapy;Mutation;Natural Killer Cells;Nivolumab;North America;novel therapeutic intervention;novel therapeutics;Oncoproteins;Opportunistic Infections;Outcome;Pathogenesis;Patients;Pattern;peer;perforin;Peripheral Blood Mononuclear Cell;Phenotype;Play;Population;prevent;Production;Prognosis;prognostic model;programmed cell death ligand 1;programmed cell death protein 1;Proliferating;Refractory Disease;Regulatory T-Lymphocyte;Reporting;response;Sampling;T cell clonality;T cell receptor repertoire sequencing;T cell response;T-Cell Activation;T-Cell Receptor;T-Lymphocyte;T-Lymphocyte Subsets;targeted treatment;Taxes;Testing;Therapeutic;Time;TNF gene;transcription factor;transcriptomics;treatment comparison;Treatment outcome;treatment response;Universities;Viral;XCL1 gene;Zidovudine

PROJECT_TITLE: Functional state of CD8+ T cell immunity in adult T-cell leukemia/lymphoma

STUDY_SECTION: TIR

STUDY_SECTION_NAME: Therapeutic Immune Regulation Study Section[TIR]


ADMINISTERING_IC: AG

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging

ORG_CITY: BAR HARBOR

ORG_NAME: JACKSON LABORATORY

ORG_STATE: ME

PHR: PROJECT NARRATIVE The NIA Interventions Testing Program (ITP) is a multi-institutional collaboration investigating interventions with the potential to extend lifespan and delay disease or dysfunction in mice. Data management, integration, analysis, and reuse are key to supporting discovery and inference of new knowledge to improve the predictive value of biological information in characterizing normal aging, health span, and age-related diseases. A Data Coordinating Center is critical to complement these efforts as it will be ever more vital to rely on biological data that have been rigorously curated and made publicly available, allowing the scientific community to build upon cumulative results and gain new insights about aging and health span using data from this collaborative effort.

PI_NAMEs: BOGUE, MOLLY A (contact)

PROGRAM_OFFICER_NAME: COGLIATI, TIZIANA PAOLA

PROJECT_TERMS: age-related disease;Aging;Amino Acids;Ancillary Study;Architecture;archive data;Basic Science;Biological;Biological Specimen Banks;Biology;Biology of Aging;Chelating Agents;Clinic;Collaborations;collaborative environment;Communities;Complement;Computational Science;Data;Data Analyses;data archive;Data Collection;Data Coordinating Center;data curation;data dissemination;data management;data repository;data reuse;Data Science;Data Set;Data Storage and Retrieval;data visualization;Databases;design;dietary supplements;Disease;Documentation;Electronics;Ensure;Equipment and supply inventories;Evaluation;experience;Experimental Designs;extend lifespan;Failure;Food;Functional disorder;Genomics;Geropathology;Goals;Growth;Health;healthspan;Hormones;Image;improved;Informatics;insight;Institution;Intervention;Investigational Drugs;Knowledge;Laboratories;Leadership;Life Cycle Stages;life span;member;Michigan;model organism;Modernization;Mollies;mouse genetics;Mus;normal aging;Nutraceutical;Outcome;Oxidation-Reduction;Pathology;Peptides;Pharmacologic Substance;phenome;Phenotype;Plant Extracts;Population;Population Heterogeneity;pre-clinical;Predictive Value;programs;Protocols documentation;public database;quality assurance;repository;Reproducibility;Research;Research Personnel;Resources;response;Sampling;Scientific Advances and Accomplishments;Shock;Site;software development;Software Engineering;software systems;Standardization;Statistical Data Interpretation;System;Testing;Texas;The Jackson Laboratory;Thinness;tool;transcriptomics;Translations;trustworthiness;Universities;Update;Visualization;Visualization software;web site;Work

PROJECT_TITLE: Mouse Phenome Database: NIA Interventions Testing Program Data Coordinating Center

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-3 (J1)]


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Injury;Clinical Research;Firearms Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Physical Injury - Accidents and Adverse Effects;Racial and Ethnic Minority Health Research;Social Determinants of Health;Violence Research

ORG_CITY: INDIANAPOLIS

ORG_DEPT: PEDIATRICS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: PROJECT NARRATIVE Exposure to firearm injury is associated with increased adverse health and mental health needs, further compounding existing health and racial inequities, but few interventions exist to address family and household member health outcomes. This innovative study will develop a methodology to link and define members at the family and household level and has the potential to significantly extend our understanding of the racial and health inequities associated with exposure to firearm injury (and other health outcomes) beyond the direct survivor to inform clinical and community interventions to prevent future morbidity and mortality.

PI_NAMEs: MAGEE, LAUREN A (contact)

PROGRAM_OFFICER_NAME: BROWN, PATRICK

PROJECT_TERMS: Accident and Emergency department;Acute;acute stress;Address;Adoption;Adult;Affect;Attention;Birth;Birth Certificates;Caregivers;Cessation of life;Child;Chronic;Chronic stress;Clinical;clinical care;Clinical Sciences;Communities;community intervention;County;COVID-19 pandemic;Data;data repository;Development;Diagnosis;Disease;Event;experience;Exposure to;Family;Family member;Firearms;Future;Goals;Gun injury;Health;health inequalities;health record;Healthcare;high risk;Household;Household and Family;indexing;Indiana;Individual;Injury;innovation;Inpatients;insurance plan;Intervention;Link;longitudinal dataset;Marriage;Medicaid;member;Mental Health;Methodology;Methods;Morbidity - disease rate;mortality;Names;Nature;Outcome;Outpatients;Parents;Persons;Police;Population;population health;prevent;Public Health;Qualitative Research;racial disparity;Records;Research;Single Parent;Social support;Survivors;System;Time;Translational Research;Trauma;Vulnerable Populations;Woman;Work;Youth

PROJECT_TITLE: The Translational Efficiency of Linking Family and Household Members to Study and Intervene on the Ripple Effects of Trauma

STUDY_SECTION_NAME: Special Emphasis Panel[ZTR1 CI-6 (01)]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cannabinoid Research;Cardiovascular;Congenital Structural Anomalies;Endocannabinoid System Research;Heart Disease;Hypertension;Kidney Disease;Patient Safety;Pediatric;Polycystic Kidney Disease;Prevention

ORG_CITY: Aurora

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Our study will evaluate the role of the endocannabinoid system in hypertension. Based on our previous data, we hypothesize that intensive (<120mm Hg) as compared to standard (<140mm Hg) blood pressure control as performed within the SPRINT trial participants will be accompanied by higher levels of the endocannabinoid anandamide and its congeners. We also hypothesize that subjects with a faster and greater rate of anandamide increase will present with increased incidence of serious adverse effects including hypotension, bradycardia and electrolyte abnormalities.

PI_NAMEs: KLAWITTER, JELENA  (contact)

PROGRAM_OFFICER_NAME: SIDDIQUI, AYESHA SAEED

PROJECT_TERMS: Acute;Acute Renal Failure with Renal Papillary Necrosis;Adult;Adverse effects;Adverse event;Age;anandamide;Angiotensin II;Animals;Anti-Hypertensive Agents;Autosomal Dominant Polycystic Kidney;biological systems;Blood;Blood Pressure;blood pressure control;blood pressure intervention;blood pressure reduction;blood pressure regulation;Bradycardia;Cardiovascular Diseases;cardiovascular disorder risk;Cardiovascular Physiology;cardiovascular risk factor;Cause of Death;Characteristics;Clinical;Data;demographics;Development;drug development;Electrolytes;Endocannabinoids;endogenous cannabinoid system;Enzymes;Event;experience;Future;General Population;Hypertension;hypertension treatment;hypertensive;Hypotension;Incidence;Individual;Intervention Trial;Knowledge;marijuana use;marijuana user;Mediating;normotensive;Participant;Patients;Plasma;Play;Predisposing Factor;preservation;Process;Race;Randomized;receptor;Renin-Angiotensin System;Reporting;Risk;Risk Factors;Role;Sampling;Serious Adverse Event;sex;Signal Transduction;Syncope;System;Testing;United States;Vasodilation

PROJECT_TITLE: Anandamide in blood pressure control

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-K (J1)]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

ORG_CITY: DENVER

ORG_NAME: NATIONAL JEWISH HEALTH

PHR: PROJECT NARRATIVE Chronic beryllium disease (CBD) develops in up to 16% of Be-exposed workers and progresses to end-stage respiratory failure in one-third of these patients. Beryllium sensitization (BeS) is the precursor of CBD. This study will determine if complement activation in nasal and bronchial epithelial cells perpetuates the immune response contributing to the exposure-mediated immune disease, CBD.

PI_NAMEs: CHU, HONG W;LI, LI  (contact)

PROGRAM_OFFICER_NAME: HUMBLE, MICHAEL C

PROJECT_TERMS: adaptive immune response;adaptive immunity;Address;Air;airway epithelium;Antigens;Asthma;Autologous;Beryllium;Biological Markers;bronchial epithelium;Brush Cell;CD4 Positive T Lymphocytes;CD55 Antigens;Cell Line;Cells;Cessation of life;Chronic berylliosis;Clustered Regularly Interspaced Short Palindromic Repeats;Coagulation Process;Coculture Techniques;Complement;Complement 1q;Complement 3 Convertase;Complement Activation;complement pathway;complement system;cytokine;Data;decay acceleration;Development;Disease;Enzymes;Epithelial Cells;Epithelium;Exposure to;Extrinsic allergic alveolitis;Fibrosis;first responder;Future;Gene Activation;gene complementation;Gene Expression;Gene Expression Profiling;General Population;Genes;Genetic Predisposition to Disease;Genetic Transcription;genetic variant;Genomics;Goals;Granulomatous;granulomatous lung disease;HLA-DPB1 gene;Human;idiopathic pulmonary fibrosis;IL6 gene;IL8 gene;Immune;Immune response;Immune System Diseases;Individual;Industry;Inflammatory;Interleukin-1 beta;Investigation;knock-down;Link;Liquid substance;Lung;Lung Diseases;Mediating;Modeling;mRNA Expression;Nasal Epithelium;Natural Immunity;Nature;Non-Invasive Detection;Nose;novel;Organ;Other Genetics;overexpression;Pathogenicity;Pathway interactions;Patients;Proteins;Public Health;Pulmonary Inflammation;rapid detection;Regulatory Pathway;Respiratory Failure;response;Risk;Role;Sarcoidosis;Serum;System;T cell response;TNF gene;transcriptome sequencing;Validation;Variant;Workplace

PROJECT_TITLE: The Role of Airway Epithelial Complement in Chronic Beryllium Disease

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biotechnology;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: CAMBRIDGE

ORG_NAME: BROAD INSTITUTE, INC.

ORG_STATE: MA

PHR: Deep reinforcement learning offers the ability to learn effective empirical algorithms for hard combinatorial optimization problems on high dimensional inputs, allowing us to shift method development from hand-engineered heuristics to data-driven models that can detect and leverage complex patterns in the data. In this proposal we aim to use deep reinforcement learning for the problem of read-based haplotype assembly using data from different sequencing platforms. Improving the accuracy of the assembled human genome haplotypes will have a significant impact on population and medical genetics, and especially on our ability to better characterize and diagnose diseases caused by rare variants.

PI_NAMEs: POPIC, VICTORIA  (contact)

PROGRAM_OFFICER_NAME: ARGUELLO, ALEXANDER

PROJECT_TERMS: Agreement;Algorithms;Alleles;Architecture;Attention;autism spectrum disorder;Autoimmune Diseases;Base Sequence;Benchmarking;Cardiovascular Diseases;Chromosomes;combinatorial;Combinatorial Optimization;Complex;Conflict (Psychology);Coupled;Data;Data Set;data-driven model;de novo mutation;deep learning;deep neural network;deep reinforcement learning;density;design;Diagnosis;Discipline;Disease;disease diagnosis;Engineering;Ensure;experience;Formulation;Genes;Genome;genome sequencing;genomic data;Genotype;Goals;Graph;graph neural network;Hand;Haplotypes;Heterozygote;heuristics;Hi-C;high dimensionality;Human;Human Genome;human population genetics;improved;Individual;Inherited;Label;Large-Scale Sequencing;Learning;learning algorithm;Length;Malignant Neoplasms;Manuals;Medical Genetics;method development;model generalizability;Modeling;Molecular;multidimensional data;neural network architecture;novel;Pattern;Phase;Phenotype;Policies;Population;Population Genetics;Population Statistics;Problem Formulations;Psychological reinforcement;rare variant;reconstruction;repository;Research;Rewards;sequencing platform;Single Parent;Site;Sorting;Structure;Techniques;Technology;Training;training data;Variant;Weight;whole genome;Work

PROJECT_TITLE: A deep reinforcement learning framework for haplotype assembly

STUDY_SECTION: GCAT

STUDY_SECTION_NAME: Genomics, Computational Biology and Technology Study Section[GCAT]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Biotechnology;Eczema / Atopic Dermatitis;Genetics

ORG_DEPT: DERMATOLOGY

PHR: PROJECT NARRATIVE: Impaired skin development and barrier function significantly impact health and quality of life in patients with inherited ichthyoses and atopic dermatitis. The primary objective of this work is to understand how deficiencies in three skin enriched lipases (epidermal lipases) affect skin development and skin barrier function. Understanding the consequences of epidermal lipase deficiencies may provide insights into the molecular functions of these proteins and could lead to novel therapies for inherited ichthyoses and atopic dermatitis.

PI_NAMEs: TURNER, MATTHEW J (contact)

PROGRAM_OFFICER_NAME: KOCH, PETER

PROJECT_TERMS: Acute;Adult;Affect;Amino Acid Sequence;Atopic Dermatitis;autosome;Biological;Biological Models;Biological Process;Biology;Cells;Ceramides;Cholesterol Esters;Chronic;clinically relevant;conditional knockout;Congenital ichthyosis;CRISPR/Cas technology;Data;Defect;design;Disease;Exhibits;experimental study;Fatty Acids;Gene Targeting;Genes;Genomics;Goals;Health;Histologic;Human;human model;Ichthyoses;Impairment;In Vitro;in vivo;Individual;inducible Cre;Inherited;insight;keratinocyte;keratinocyte differentiation;knockout gene;Knockout Mice;Lesion;Light;Link;Lipase;Lipids;loss of function mutation;Mass Spectrum Analysis;Mediating;Mediator;Molecular;mouse model;Mus;Mutation;novel;novel therapeutic intervention;novel therapeutics;Pathogenicity;Pathologic;Pathology;Patients;Persons;Play;protein function;Proteins;Proteome;Psoriasis;Quality of life;Reporting;Research;Role;Skin;skin barrier;skin disorder;skin organogenesis;Stratum Granulosum;Structure;System;Tamoxifen;Transcript;Work

PROJECT_TITLE: Pathologic consequences of epidermal lipase deficiencies

STUDY_SECTION: ACTS

STUDY_SECTION_NAME: Arthritis, Connective Tissue and Skin Study Section[ACTS]


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Infectious Diseases;Lung;Pediatric;Prevention;Vaccine Related

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE COVID-19 remains the leading infectious cause of death in children and one of the top ten causes of pediatric death in the U.S. Although other respiratory viruses co-circulating with SARS-CoV-2 may exacerbate the morbidity and mortality attributed to COVID-19, the combined effect of common respiratory viruses (i.e., respiratory syncytial virus, influenza virus) with SARS-CoV-2 is not well understood. To address this knowledge gap, this application proposes the innovative use of an existing, large national U.S. claims-based cohort to evaluate the risk and severity of viral co-infections associated with SARS-CoV-2 in U.S. children and the potential benefits of COVID-19 vaccination.

PI_NAMEs: REGAN, ANNETTE KARENA (contact)

PROGRAM_OFFICER_NAME: PLIMACK, MARY KATHERINE BRADFORD

PROJECT_TERMS: 18 year old;2 year old;2019-nCoV;4 year old;5 year old;Academy;Acute;Acute Respiratory Distress Syndrome;Address;Adult;Affect;age group;Age Months;American;Arrhythmia;Benefits and Risks;Blood Coagulation Disorders;Body System;Cardiovascular Diseases;Caregivers;Cause of Death;Centers for Disease Control and Prevention (U.S.);Cessation of life;Child;Childhood;Chronic lung disease;co-infection;cohort;COVID-19;COVID-19 burden;COVID-19 complications;COVID-19 impact;COVID-19 incidence;COVID-19 prevention;COVID-19 risk;COVID-19 severity;COVID-19 vaccination;COVID-19 vaccine;Data;Databases;Decision Making;Disease;Dose;Ensure;Epidemiology;Evaluation;evidence base;experience;Goals;Health;Health Benefit;Health Personnel;Heart Injuries;Heterogeneity;high risk;Hospitalization;hospitalization rates;Immunization;Incidence;Infection;Influenza;influenza infection;influenzavirus;Injury to Kidney;innovation;Insurance;Knowledge;liver injury;Medicaid;Medical;medical complication;Morbidity - disease rate;mortality;Multisystem Inflammatory Syndrome in Children;Nervous System Disorder;Outcome;Parents;pediatrician;Policies;premature;Prevention strategy;Recommendation;Reporting;Research;Respiratory Failure;respiratory infection virus;Respiratory syncytial virus;Respiratory Syncytial Virus Infections;Respiratory Tract Infections;respiratory virus;Rhabdomyolysis;Rhinovirus;Risk;Risk Reduction;Sampling;SARS-CoV-2 B.1.1.529;SARS-CoV-2 infection;Severe Acute Respiratory Syndrome;severe COVID-19;Severities;Severity of illness;Shock;Translating;Vaccination;Variant;Viral;Virus

PROJECT_TITLE: SARS-CoV-2 and respiratory virus co-infections among young children

STUDY_SECTION: PRID

STUDY_SECTION_NAME: Population based Research in Infectious Disease Study Section[PRID]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Autoimmune Disease;Brain Disorders;Multiple Sclerosis;Neurodegenerative;Neurosciences

ORG_CITY: SAN ANTONIO

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF TEXAS SAN ANTONIO

PHR: Proteins of the myelin sheath, such as myelin basic protein (MBP) and myelin oligodendrocyte protein (MOG) have been extensively studied in MS pathogenesis; surprisingly, very little is known about the changes to lipids components of the myelin sheath during the disease process, in particular as it relates to changes in the composition of key myelin lipids during relapses, remission, and progression of MS. Modifications in myelin lipids composition during disease relapses may critically affect the progression of MS, for example by providing targets for lipid peroxidation; this may provide druggable lipid-based targets, which have previously not been explored. This proposal will therefore address an urgent unmet need by determining the effects and mechanism of neuroinflammation on the composition of myelin lipids in relevant preclinical EAE models and help to develop better treatments for progressive MS.

PI_NAMEs: BACH, STEPHAN B. H.;FORSTHUBER, THOMAS G. (contact)

PROJECT_TERMS: Acetylcysteine;Address;Affect;Antibodies;Antioxidants;Area;astrogliosis;Automobile Driving;Axon;Biological;Brain;cell type;Cells;central gray matter;Central Nervous System;Combined Modality Therapy;copolymer 1;cytokine;Data;Demyelinations;Detection;Disease;Disease Progression;Disease remission;Experimental Autoimmune Encephalomyelitis;Galactosylceramides;Gene Expression;Glycolipids;Image;Imaging Techniques;Immune;immune cell infiltrate;Immunofluorescence Immunologic;In Situ;Inflammation Mediators;Inflammatory;Inflammatory Infiltrate;insight;Knowledge;Label;Lesion;Lipid Peroxidation;lipidome;Lipids;MALDI-TOF Mass Spectrometry;Maps;mass spectrometric imaging;Metabolic;meter;Methods;Modeling;Modification;Molecular;molecular imaging;multimodality;Multiple Sclerosis;multiple sclerosis patient;Mus;Myelin;Myelin Basic Proteins;Myelin Proteins;Myelin Sheath;Neuroglia;neuroinflammation;novel;novel strategies;oligodendrocyte-myelin glycoprotein;Oligodendroglia;Pathogenesis;Pathologic;Pathway interactions;Phase;Play;pre-clinical;Process;Proteins;Proteomics;Recurrent disease;Relapse;Reporting;Residual state;Resolution;SJL/J Mouse;Spatial Distribution;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;Spinal Cord;Stains;Sulfoglycosphingolipids;Testing;Time;Tissues;two-dimensional;Visualization;white matter

PROJECT_TITLE: Investigating changes in myelin lipid composition during relapsing-remitting neuroinflammation

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


NIH_SPENDING_CATS: Behavioral and Social Science;Burden of Illness;Caregiving Research;Chronic Liver Disease and Cirrhosis;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Health Services;Liver Disease;Patient Safety;Rehabilitation

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: PROJECT NARRATIVE In its advanced stages, chronic liver disease is burden to patients, their caregivers, and the healthcare system, especially when hospital-based care is needed. This proposal will assess the feasibility of a Hospital at Home program as a novel model for providing patient-centered, technology driven care. The study will also elicit patient and caregiver feedback to design a refined Hospital at Home program for a future, large-scale study.

PI_NAMEs: DESAI, ARCHITA P. (contact)

PROGRAM_OFFICER_NAME: LOH, KATRINA SHUEH WEN

PROJECT_TERMS: Acute;acute care;Address;Admission activity;aged;Ambulatory Care;American;ancillary care;care systems;Caregiver Burden;Caregivers;Caring;Cause of Death;chronic liver disease;Cirrhosis;Client satisfaction;Clinical;Collection;Country;Data Collection;design;disability;Economics;efficacy trial;end stage liver disease;Enrollment;Ensure;ethnic minority;experience;Family Caregiver;Family member;Feedback;follow-up;Foundations;Future;Goals;Health;health care delivery;health care service utilization;health related quality of life;healthcare burden;Healthcare Systems;Heart failure;Hepatology;high risk;high risk population;Home;Home environment;hospital care;Hospital Design;hospital readmission;Hospitalization;Hospitals;Hour;human centered design;improved;Indiana;Individual;Infection;innovation;inpatient service;Inpatients;Interview;Length;Length of Stay;Liver diseases;Measurement;Measures;Medical;meetings;Methodology;Modeling;Monitor;mortality;novel;Observational Study;Participant;patient home care;patient oriented;Patient Outcomes Assessments;Patient Selection;Patients;Pharmaceutical Preparations;Pilot Projects;Population;Prevalence;Procedures;programs;prospective;Prospective Studies;Provider;public health emergency;Quality of life;Randomized, Controlled Trials;recruit;Rehabilitation therapy;Reporting;Research Design;response;Safety;SARS-CoV-2 infection;satisfaction;Science;Service delivery model;Services;Solid;Structure;success;Technology;Titrations;United States Centers for Medicare and Medicaid Services;Universities;Visit;waiver

PROJECT_TITLE: Innovating acute care for liver disease through a pilot, patient-centric Hospital@Home program


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: PHILADELPHIA

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

ORG_STATE: PA

PHR: Project Narrative Adenosine triphosphate-binding cassette transporter subfamily A member 7 (ABCA7) significantly bears on the risk of Alzheimer's disease by a poorly understood mechanism. The present project entails making a mouse model of inducible expression of the human ABCA7. This model will facilitate the studies into the mechanism of neuroprotective activity by ABCA7 and will be useful for preclinical work to assess feasibility of ABCA7 as a target of therapy for Alzheimer's disease.

PI_NAMEs: LYSSENKO, NICHOLAS  (contact)

PROGRAM_OFFICER_NAME: DIBATTISTA, AMANDA

PROJECT_TERMS: Abeta clearance;Adenosine Triphosphate;Affect;Age;Age Years;Agreement;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease risk;Alzheimer's disease therapy;Amino Acids;Amyloid beta-42;Amyloid beta-Protein;Amyloid beta-Protein Precursor;Apolipoprotein E;Astrocytes;ATP binding cassette transporter 1;Binding;Biochemical;Biochemical Pathway;Brain;Breeding;Buffers;Cells;Cerebrospinal Fluid;Cholesterol;Cholesterol Homeostasis;Chromosome 21;Compensation;Cre-LoxP;Data;Dementia;Disease;Disease Progression;Down's Syndrome;Early Onset Familial Alzheimer's Disease;Enzyme-Linked Immunosorbent Assay;Excision;Exons;experimental study;Female;gene discovery;gene function;Genes;Genetic;Genetic Transcription;Healthcare Systems;Hippocampus;Human;in vivo;Individual;inducible gene expression;insight;Investigation;Knock-out;Knockout Mice;Late Onset Alzheimer Disease;lipid transport;lipidomics;Lipids;Lipoproteins;Longevity;male;Mass Spectrum Analysis;Mediating;member;Metabolism;Modeling;mouse model;Mus;Mutate;Nerve Degeneration;neural;Neurophysiology - biologic function;neuroprotection;overexpression;Parietal;Parietal Lobe;Pathogenesis;Pathologic;Phospholipids;Physiology;pre-clinical;Prefrontal Cortex;premature;Production;Productivity;promoter;Protein Isoforms;Protein Overexpression;Proteins;RNA;Role;side effect;Solubility;System;Tamoxifen;targeted treatment;Terminator Codon;Testing;Tissues;TNFSF5 gene;tool;Transgenes;Trisomy;Work;β-amyloid burden

PROJECT_TITLE: Inducible overexpression of ABCA7 in astroglia in vivo as a means to study its function in disease pathogenesis

STUDY_SECTION: CDIN

STUDY_SECTION_NAME: Chronic Dysfunction and Integrative Neurodegeneration Study Section[CDIN]


ORG_CITY: ALBUQUERQUE

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR

ORG_STATE: NM

PHR: The proposed project will help researchers and clinicians better understand the molecular mechanisms that cause or exacerbate Alzheimer’s disease (AD) and/or Frontotemporal Dementia (FTD). This will be achieved by identifying whether a family of proteins not previously associated with AD/FTD, are critical for altering protein trafficking and processing of other proteins that are known to play a role in both AD and FTD. The information gained from this research can be used to identify potential avenues for treating and/or preventing AD/FTD.

PI_NAMEs: WEICK, JASON P (contact)

PROGRAM_OFFICER_NAME: LI, TONG

PROJECT_TERMS: Abeta synthesis;Affect;Age;aging related disease;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease patient;Alzheimer's disease related dementia;Alzheimer's disease therapeutic;Amyloid beta-Protein;Amyloid beta-Protein Precursor;Apolipoprotein E;Autopsy;beta secretase;Binding;Brain;brain tissue;C-terminal;Caring;Cell surface;Cells;Cholesterol;Clinical;Co-Immunoprecipitations;cost;Data;Dementia;Dendrites;design;Development;differential expression;Disease;disorder subtype;Down-Regulation;Early Onset Alzheimer Disease;evidence base;extracellular;Family member;Frontotemporal Dementia;Frontotemporal Lobar Degenerations;Future;Gene Family;Genes;Genetic;Genome;genome wide association study;Goals;Health;Healthcare Systems;Human;In Vitro;Individual;Investigation;Knowledge;Late Onset Alzheimer Disease;Lesion;Link;lipid metabolism;Measures;Mediator;member;Molecular;Nervous System Disorder;Neuregulin 1;Neurofibrillary Tangles;Neurons;novel;novel therapeutics;Pathologic;Pathologic Processes;Pathology;Pathway interactions;Patients;Penetrance;PGRN gene;Play;Population;presenilin;prevent;Primates;Process;Production;protein E;Protein Family;protein TDP-43;protein transport;Proteins;Proteolysis;Proteolytic Processing;Proteomics;Quantitative Trait Loci;receptor;Regulation;Reporting;Research;Research Personnel;risk variant;Rodent;Rodent Model;Role;Sampling;Senile Plaques;sortilin;Specificity;success;Symptoms;Synaptic plasticity;tau-1;Testing;therapeutic development;Therapeutic Intervention;Tissues;trafficking;Work

PROJECT_TITLE: Regulation of Sortilin-1 by Neuron-Specific Genes; implications for AD and FTD

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Contraception/Reproduction;Endometriosis;Estrogen;Genetics;Human Genome;Orphan Drug;Rare Diseases;Women's Health Research

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Adenomyosis is a common, chronic gynecologic disorder where the uterine lining (endometrium) migrates into the myometrium, causing severe menstrual cramps, bleeding, subfertility, and poor pregnancy outcomes. Its pathogenesis and pathophysiology are poorly understood and understudied, and as current medical and surgical therapies are suboptimal, new and effective therapies are needed. Herein we propose a single cell transcriptomic and spatial proteomic analysis of the three contiguous endometrial-myometrial junction compartments (endometrial functionalis, endometrial basalis, and subendometrial inner myometrium) and a transcriptome- based computational drug-repurposing strategy to identify new and re-purposed drugs through signature reversal that together are anticipated to inform mechanisms of adenomyosis pathophysiology and novel therapeutic strategies to mitigate adenomyosis-related symptoms.

PI_NAMEs: GIUDICE, LINDA C (contact);SIROTA, MARINA

PROGRAM_OFFICER_NAME: TINGEN, CANDACE M

PROJECT_TERMS: Abate;Abnormal Cell;Adenomyosis;Affect;analog;Anemia;Archives;associated symptom;Atlases;Back;biobank;Bioinformatics;cell motility;Cell Nucleus;cell type;Cells;Cellular biology;Cesarean section;Characteristics;Chronic;common treatment;Communities;Computational Science;Contraceptive Agents;Curettage procedure;Cytokine Receptors;Cytometry;Data;Data Set;Databases;Diffuse;Disease;disease phenotype;Disease regression;drug development;drug discovery;drug repurposing;Dysmenorrhea;effective therapy;Endometrial;Endometrial Disorder;Endometrium;Environmental Estrogen;Estrogens;Excision;Functional disorder;Future;Gene Expression;Genomics;GNRH1 gene;Goals;Gynecologic;Gynecology;Hemorrhage;high throughput technology;Histone Deacetylase Inhibitor;Homeostasis;Hormonal;Human;Hyperplasia;Hypertrophy;Hysterectomy;Iatrogenesis;IL17 gene;Image;Immunology;improved;in silico;In Vitro;in vivo Model;Individual;Inflammation;insight;Intercellular Junctions;interest;Ligands;Medical;Menstrual cycle;Microscope;migration;Molecular;Molecular Biology;multidisciplinary;Muscle Cramp;Myometrial;myometrium;Non-Steroidal Anti-Inflammatory Agents;novel;novel therapeutic intervention;novel therapeutics;Operative Surgical Procedures;Pathogenesis;Pathway interactions;Patients;Personal Satisfaction;Pharmaceutical Preparations;Phase;Phenotype;Physiological;Population;preclinical study;Pregnancy;Pregnancy Outcome;preservation;Production;Progesterone;Progestins;Property;prospective;Proteomics;Quality of life;receptor;reduce symptoms;Research;Resolution;Resources;Risk Factors;Sampling;Signal Transduction;single nucleus RNA-sequencing;Smooth Muscle;Specimen;Spontaneous abortion;Steroids;subfertility;symptom management;Symptoms;Technology;therapeutic target;Thick;Tissues;TNF gene;transcriptome;transcriptome sequencing;transcriptomics;Trauma;trying to conceive;Uterine Diseases;Uterine myomectomy;Uterus;Woman;wound healing

PROJECT_TITLE: Single cell analytics and drug discovery at the endometrial-myometrial junction in symptomatic adenomyosis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-J (96)]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Cancer;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Genetics;Immunotherapy;Infectious Diseases;Precision Medicine;Prevention

ORG_CITY: NEW YORK

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: PROJECT NARRATIVE. Prolonged infection in immunocompromised subjects with hematological malignancies may play a major role in the emergence and transmission of SARS-CoV-2 variants. We will use a combination of advanced epidemiological, immunological, and molecular methods to determine the effect of host background and treatments on viral persistence and evolution, and the effect on clinical outcome. Information from our study could be used to develop targeted interventions to prevent emergence and spread of treatment-resistant and/or more fit variants.

PI_NAMEs: SALVATORE, MIRELLA  (contact)

PROGRAM_OFFICER_NAME: BOZICK, BROOKE ALLISON

PROJECT_TERMS: 2019-nCoV;acute COVID-19;Acute Disease;acute infection;Address;Affect;Antibodies;Antibody Response;B-Lymphocytes;Biological;Blood specimen;Cells;Characteristics;Chronic;chronic infection;Clinical;Clinical Data;cohort;Communities;COVID-19;COVID-19 patient;COVID-19 treatment;COVID-19 vaccine;Data;data integration;deep sequencing;Defect;Development;Disease;Disease Management;Disease Progression;disease transmission;DNA Sequence Alteration;Early identification;emerging virus;epidemiologic data;Epidemiology;Event;Evolution;experience;fitness;General Population;Genetic Variation;Goals;Hematologic Neoplasms;high dimensionality;high risk;Immune;Immune system;Immunity;Immunocompetent;Immunocompromised Host;immunodeficiency;Immunologics;Immunomodulators;Immunophenotyping;Immunosuppression;Immunosuppressive Agents;Immunotherapy;Individual;Infection;Infection Control;Intervention;Link;Malignant Neoplasms;Methods;Molecular;Mutation;nasopharyngeal swab;novel;optimal treatments;Outcome;Patients;personalized therapeutic;Persons;Phenotype;Play;Population;predictive tools;prevent;Preventive measure;Public Health;public health intervention;replication therapy;Research;Resistance;resistance mutation;respiratory virus;RNA Viruses;Role;Sampling;SARS-CoV-2 antiviral;SARS-CoV-2 infection;SARS-CoV-2 transmission;SARS-CoV-2 variant;Sequence Analysis;Severities;Severity of illness;Source;Specificity;Steroids;Symptoms;T cell response;T-Lymphocyte;targeted treatment;Therapeutic;therapeutically effective;Time;tool;transmission process;Variant;Viral;viral genomics;Viral Load result;Viral reservoir;Virus;Virus Diseases;virus genetics;virus host interaction;Virus Replication

PROJECT_TITLE: The effects of immunosuppression on SARS-CoV-2 persistence, virus genetic diversity and clinical outcomes of COVID-19

STUDY_SECTION: VDT

STUDY_SECTION_NAME: Viral Dynamics and Transmission Study Section [VDT]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biotechnology;Brain Disorders;Dementia;Gene Therapy;Genetics;Neurodegenerative;Neurosciences;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: Nashville

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: Project narrative Alzheimer’s disease (AD) afflicts over 6.5 million Americans, imposes drastic burdens on patients’ families and society, and is the sixth leading cause of death in the US. Currently, there are no treatments that alter the course of AD. This proposal aims to investigate strategies for genetic engineering cells of the central nervous system to enable customizable control over cell functions in the face of pathology that characterizes AD, with the goal of potentiating effective, reliable therapeutics to combat AD.

PI_NAMEs: BRUNGER, JONATHAN MATTHEW (contact)

PROGRAM_OFFICER_NAME: RUNKO, ALEXANDER PETER

PROJECT_TERMS: 3-Dimensional;abeta oligomer;Alzheimer associated neurodegeneration;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease therapy;American;Amyloid beta-Protein;amyloid pathology;Anti-Inflammatory Agents;Antibodies;Astrocytes;Behavior;Behavior Control;beta amyloid pathology;Biochemical;Biological;Brain;Brain region;Brain-Derived Neurotrophic Factor;Cause of Death;cell behavior;Cell Physiology;Cell Therapy;Cell Transplantation;cell type;Cells;Central Nervous System;Cerebral Amyloid Angiopathy;Cessation of life;chemokine;Clinical Research;combat;Complement;Complement Activation;Cryoultramicrotomy;Cues;cytokine;Deterioration;Disease;Disease Progression;Drug Delivery Systems;Edema;Engineering;Environment;Enzyme-Linked Immunosorbent Assay;experimental study;Family;Foundations;Gene Expression Profiling;gene therapy;Genes;genetic approach;Genetic Engineering;Genotype;Goals;Health;Heart Diseases;HIV;Human;human pluripotent stem cell;hyperphosphorylated tau;Image;Immunotherapy;In Situ;In Vitro;in vitro Model;innovation;Ligands;Methods;Microglia;Microscopy;Modeling;Monitor;Mus;nanobodies;Nerve Degeneration;nerve stem cell;neural stimulation;Neurites;Neuroglia;neuron loss;Neuronal Plasticity;Neurons;neuroprotection;Neurotransmitters;notch protein;Onset of illness;Output;Pathogenicity;Pathologic;Pathology;Patients;Pharmaceutical Preparations;Play;prevent;programs;Reaction;receptor;Regenerative Medicine;Regulation;Reporter;Reporter Genes;Reporting;response;Risk;Role;Senile Plaques;Signal Transduction;Site;Slice;Societies;spatial relationship;Stains;stem cell model;stem cells;Stroke;Symptoms;Synapses;synthetic biology;Synthetic Genes;System;tau Proteins;tau-1;Technology;Testing;Therapeutic;Therapeutic Agents;therapeutic transgene;tool;Training;transcriptome sequencing;transgene expression;Transgenes;Transplantation;Work

PROJECT_TITLE: Regulated gene circuits for Alzheimer's disease therapy

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


ORG_CITY: DAVIS

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Project Narrative The clinical benefits of precision medicine have been limited because genetic predictions in people with ancestries different from the overwhelmingly European- ancestry discovery cohorts are highly error prone. Among the possible factors that can cause this portability issue, gene-by-gene interaction or “epistasis”, has received much less attention as compared to differences in linkage disequilibrium or population-specific causal variants. This study will estimate the extent that gene-by-gene interactions impact phenotypic variation by testing for ancestry-specific effects on methylation in an admixed African population.

PI_NAMEs: HENN, BRENNA M (contact)

PROGRAM_OFFICER_NAME: DAYAL, JYOTI

PROJECT_TERMS: Address;Admixture;Affect;African;African ancestry;Algorithms;Americas;Asian population;Asthma;Attention;Biological Assay;Cardiovascular Diseases;causal variant;Clinical;cohort;Collaborations;CpG dinucleotide;Data;Data Set;disorder risk;DNA;Environment;European;European ancestry;experience;Frequencies;gene environment interaction;Gene Frequency;gene interaction;Generations;Genes;Genetic;genetic architecture;Genetic Epistasis;genetic predictors;Genetic Recombination;Genetic Risk;Genome;genome resource;genome wide methylation;genome-wide;genomic variation;Grant;Haplotypes;Healthcare;Heritability;Heterogeneity;Human Genome;improved;Individual;innovation;Investigation;Linkage Disequilibrium;Maps;Mediating;Methylation;Modeling;molecular phenotype;mosaic;Outcome;Participant;Persons;Phenotype;Population;portability;precision genetics;precision medicine;Prevalence;Quantitative Trait Loci;reference genome;Research Design;Risk;risk prediction;Sampling;South African;South Asian;Specificity;Stretching;Testing;trait;United States National Institutes of Health;Variant;variant detection;whole genome

PROJECT_TITLE: meQTL Discovery in Admixed Human Genomes Facilitates Estimates of Epistasis

STUDY_SECTION: GVE

STUDY_SECTION_NAME: Genetic Variation and Evolution Study Section[GVE]


NIH_SPENDING_CATS: Brain Disorders;Cancer;Cancer Genomics;Childhood Leukemia;Down Syndrome;Genetics;Hematology;Human Genome;Infectious Diseases;Intellectual and Developmental Disabilities (IDD);Pediatric;Pediatric Cancer;Prevention;Rare Diseases;Transplantation

ORG_CITY: GRAND RAPIDS

ORG_NAME: VAN ANDEL RESEARCH INSTITUTE

ORG_STATE: MI

PHR: NARRATIVE Understanding predisposition to hematological diseases, such as pediatric Acute Myeloid Leukemia (pAML) is crucial for deciphering disease pathogenesis, finding treatment targets, and selecting appropriate donors for bone marrow transplant. The interaction between germline genetic variation, viral infections, and pediatric malignancies, such as pAML, has received less attention compared to adult tumors and autoimmune diseases. Overcoming obstacles such as small sample sizes and biased cohorts, the Gabriella Miller Kids First! (GMKF) Consortium offers ample data and diverse pediatric samples to characterize germline variants as risk factors for leukemia and offers a unique opportunity to explore strategies for screening or prophylaxis to mitigate predisposition risk.

PI_NAMEs: TRICHE, TIMOTHY J. (contact)

PROGRAM_OFFICER_NAME: DUGLAS TABOR, YVONNE

PROJECT_TERMS: Acceleration;Acute Lymphocytic Leukemia;Acute Myelocytic Leukemia;Address;Adult;Affect;American;Attention;Autoimmune Diseases;autoinflammatory;Binding;Binding Sites;Bone marrow failure;Bone Marrow Transplantation;catalyst;CBFA2T1 gene;CEBPA gene;Child;Childhood;Childhood Acute Myeloid Leukemia;Childhood Leukemia;Childhood Precursor T Lymphoblastic Leukemia;chimeric gene;Classification;clinical trial participant;cohort;computer infrastructure;Congenital Abnormality;contig;CREBBP gene;Cytomegalovirus;Data;Defect;Derivative Chromosome;Development;Disease;Disease remission;Disease susceptibility;disorder risk;Donor person;dosage;Down's Syndrome;effective therapy;Elements;Enhancers;Epstein-Barr Virus Infections;Epstein-Barr Virus Nuclear Antigens;Etiology;Ewings sarcoma;Exposure to;Frequencies;Gene Expression;Gene Fusion;gene therapy clinical trial;General Population;Genetic;Genetic Counseling;genetic element;genetic variant;Genetic Variation;Genome;Germ Lines;Germ-Line Mutation;Guidelines;heart defect;Hematological Disease;Hematology;Hematopoietic Neoplasms;Herpesviridae;high risk;Human;human disease;Human Genome;Human Herpesvirus 4;Immunologic Deficiency Syndromes;improved;Incidence;Individual;Inflammation;insight;large scale data;Lead;leukemia;Liquid substance;Live Birth;Malignant Childhood Neoplasm;Medical Genetics;medical schools;micronucleus;Multiple Sclerosis;Mutation;Myeloproliferative disease;new therapeutic target;novel;Oncogene Activation;Oncogenes;overexpression;Parents;Pathogenesis;pathogenic virus;Pathogenicity;Patients;Pediatric Research;Pilot Projects;Population;Predisposition;Preleukemia;Prevalence;Prognosis;programs;Prophylactic treatment;Proteins;Ramp;Rare Diseases;RB1 gene;Risk;Risk Factors;risk stratification;RNA Splicing;Role;RUNX1 gene;Sample Size;Sampling;Sampling Biases;Scanning;screening;Short Tandem Repeat;Solid;Somatic Mutation;Source;Spottings;Susceptibility Gene;t(8;21) acute myeloid leukemia;Time;Tissues;Transcript;transcription factor;transcriptome;treatment planning;tumor;Tumor Suppressor Genes;Untranslated RNA;Variant;Viral;Viral Genome;Viral Vector;Virus Diseases;virus genetics;Virus Integration;whole genome;Work

PROJECT_TITLE: Dissecting the role of germline genetic variation and viral exposures as determinants of hematological disease predisposition

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Asthma;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Pediatric;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Women's Health Research

ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Physical inactivity is associated with worse asthma outcomes, and Black girls are disproportionately impacted by both physical inactivity and asthma morbidity. Family-based approaches to increasing physical activity are more effective and sustainable, yet no study to date addresses the unique asthma-related, culture-specific, and multi-level barriers to physical activity. This project aims to apply a theory-based approach to develop the first evidence for a dyad lifestyle physical activity intervention that is culturally tailored for urban Black girls with asthma, with the goal of improving outcomes and reducing disparities for Black girls with asthma.

PI_NAMEs: NYENHUIS, SHARMILEE MARIA;VOLERMAN, ANNA  (contact)

PROGRAM_OFFICER_NAME: GILLMAN, ARIELLE SAMANTHA

PROJECT_TERMS: acceptability and feasibility;actigraphy;Address;Adherence;Adolescence;Age;Agreement;Asthma;asthma exacerbation;asthmatic patient;Award;Behavior;behavior change wheel;Benchmarking;black men;Black race;black women;Cessation of life;Child;Clinical Trials;Communities;culturally appropriate intervention;Data;Daughter;Development;Devices;Disease;Disparity;disparity reduction;efficacy evaluation;efficacy testing;efficacy trial;Eligibility Determination;Emergency department visit;exercise capacity;exercise intervention;Exhalation;Family;feasibility testing;follow up assessment;follow-up;Funding;girls;Goals;Grant;health care service utilization;Hospitalization;Hour;improved;improved outcome;Individual;Infrastructure;International;Intervention;Intervention Trial;Interview;Life Style;Light;Link;Methods;Minority Groups;Minority Women;Modeling;Morbidity - disease rate;mortality;mother-daughter relationship;Mothers;Motivation;multidisciplinary;National Institute on Minority Health and Health Disparities;Nitric Oxide;Not Hispanic or Latino;Observational Study;Outcome;outcome disparities;parental influence;Participant;patient oriented;peer;Physical activity;physical inactivity;pilot test;Play;poor health outcome;Population;Prevalence;Program Development;pulmonary function;Qualitative Methods;Quality of life;Randomized;Recommendation;recruit;Resources;Role;sedentary;social cognitive theory;Social support;Structure;Surveys;Testing;theories;Time;tool;urban setting;Vulnerable Populations;Walking;Work

PROJECT_TITLE: Adapting and testing a physical activity dyad intervention for Black girls with asthma and their mothers

STUDY_SECTION: BMHO

STUDY_SECTION_NAME: Biobehavioral Medicine and Health Outcomes Study Section[BMHO]


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Complementary and Integrative Health;Dietary Supplements;Natural Products;Nutrition;Prevention

ORG_CITY: LOS ANGELES

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative Plant secondary metabolites exert a wide variety of beneficial effects on human health. This proposal aims to explore and elucidate the systems-level effect of plant (poly)phenolic compounds on human metabolism by comprehensive quantitation of metabolite concentrations, reaction fluxes, and free energies. Harnessing the mechanisms underlying (poly)phenolic compounds’ biological activities will promote preventive and integrative health care.

PI_NAMEs: PARK, JUNYOUNG O. (contact)

PROGRAM_OFFICER_NAME: STILL, PATRICK COLBY

PROJECT_TERMS: Affect;Animals;Anthocyanins;Anti-Inflammatory Agents;Antioxidants;Binding;Biological;Biological Availability;cell growth;Cell Line;cell type;Cells;Cellular Metabolic Process;Chlorogenic Acid;Combined Modality Therapy;Complement;Data Set;design;Diabetes Mellitus;Diet;Disease;Embryo;Environment;Enzymes;Epidemiology;Equilibrium;experimental study;extracellular;fighting;Food;Free Energy;Free Radical Formation;Free Radical Scavenging;Generations;Glucose;Glycolysis;Goals;Health;Health Benefit;Health Promotion;Healthcare;Homeostasis;Human;Individual;Infection;innovation;Integrative Medicine;Isotopes;Kidney;knowledge of results;Life;Light;Malignant Neoplasms;Mammalian Cell;Maps;Mass Spectrum Analysis;Measurement;Measures;Medicine;Metabolic;Metabolic Pathway;Metabolism;metabolomics;Methodology;Methods;mitochondrial dysfunction;Mus;NADH;NADP;Natural Products;Nature;novel;Nutrient;Obesity;Oxidation-Reduction;oxidative damage;Oxygen;Pharmaceutical Preparations;Phenols;Physiological;Phytochemical;Plants;polyphenol;Predisposition;preservation;prevent;Preventive;Property;Reaction;Research;secondary metabolite;Shotguns;small molecule;stressor;synergism;System;Techniques;Temperature;Testing;Therapeutic;Therapeutic Agents;Thermodynamics;Tissues;Tracer;uptake

PROJECT_TITLE: Exploring the mechanisms underlying plant (poly)phenols bioactivity via integrating metabolomics and fluxomics

STUDY_SECTION: CSB

STUDY_SECTION_NAME: Chemical Synthesis and Biosynthesis Study Section[CSB]


NIH_SPENDING_CATS: Biomedical Imaging;Brain Disorders;Cerebrovascular;Neurosciences;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Traumatic brain injury (TBI) is a devastating cause of death and disability. Magnetic resonance elastography (MRE) shows that the brain softens following TBI, and research suggests that such softening is strongly influenced by damage to cerebral blood vessels. Combining these recent findings is expected to dramatically improve understanding of what the brain experiences during trauma and to thus revolutionize prevention and treatment efforts.

PI_NAMEs: MONSON, KENNETH L (contact)

PROGRAM_OFFICER_NAME: UMOH, NSINI ALEASE

PROJECT_TERMS: 4D MRI;Accelerometer;Adult;Animal Model;Animals;Anisotropy;Autopsy;axon injury;Biological Markers;Blood;Blood Vessels;blood-brain barrier permeabilization;Brain;Brain Injuries;brain tissue;Cause of Death;cerebral artery;Cerebrovascular system;Cerebrum;Characteristics;cranium;Data;density;Development;Diagnosis;disability;Disease;Edema;Elements;Euthanasia;Evaluation;Event;experience;experimental study;Family suidae;Head;Hemorrhage;Histology;Histopathology;Image;improved;individual patient;Injury;insight;Investigation;Isotropy;kinematics;Magnetic Resonance Elastography;Magnetic Resonance Imaging;Maps;Mechanics;mild traumatic brain injury;Modeling;Motion;novel;Patients;Physiological;Predisposition;Prevention;Process;Property;Protocols documentation;Recovery;Research;response;Risk;Role;Rupture;Severities;Stretching;Structure;Techniques;Time;Tissues;tool;Trauma;Traumatic Brain Injury;Validation

PROJECT_TITLE: Tissue Softening in Traumatic Brain Injury

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


ADMINISTERING_IC: LM

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Behavioral and Social Science;Biodefense and Related Countermeasures;Bioengineering;Clinical Research;Data Science;Emerging Infectious Diseases;Health Services;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Orphan Drug;Rare Diseases;Telehealth;Tuberculosis

ORG_CITY: ATHENS

ORG_DEPT: ADMINISTRATION

ORG_NAME: UNIVERSITY OF GEORGIA

ORG_STATE: GA

PHR: Project Narrative This project will develop an artificial intelligence-powered tool to enhance remote video-based monitoring of medication to support proper adherence. It will use machine learning techniques to train a model to recognize fine grained pill-taking actions from a large dataset of existing medication intake videos. The model will be a valuable tool that enhances the efficiency and scalability of video directly observed treatment (VDOT), an existing video-based intervention for monitoring medication adherence across various diseases and settings.

PI_NAMEs: SEKANDI, JULIET NABBUYE (contact);SUN, JIN

PROGRAM_OFFICER_NAME: REDDY, GOUTHAM

PROJECT_TERMS: Acceleration;Adherence;Adoption;Algorithms;Area Under Curve;Artificial Intelligence;artificial intelligence model;Asthma;Behavior;Chronic Disease;Classification;Clinical;clinical practice;computer science;Computer Vision Systems;Computing Methodologies;Consent;Consumption;Cost Savings;COVID-19 pandemic;Cues;Data;Data Set;deep learning;deep neural network;Deglutition;Detection;Disease;Disease Management;Dose;drinking water;Drops;drug efficacy;effective therapy;effectiveness evaluation;efficacy trial;Ensure;Face;follow-up;Funding;Future;Gestures;Glass;Goals;Grain;Hand;Health;health care delivery;Health care facility;Health Personnel;Health Sciences;HIV;HIV/TB;Human;Human Activities;Hypertension;Image;implementation trial;improved;Ingestion;innovation;Instruction;Intake;Intervention;Interview;Jaw;Kinetics;Knowledge;Label;large datasets;Learning;Machine Learning;machine learning model;Manuals;medication compliance;Mental disorders;Methods;Modeling;Monitor;multidisciplinary;Network-based;new technology;novel;Online Systems;open label;open source;Oral;Patient Care;Patient Self-Report;Patients;Pattern;Performance;Pharmaceutical Preparations;Pharmacy facility;pill;pragmatic implementation;Protocols documentation;prototype;Public Health;remote monitoring;remote patient monitoring;remote therapy;Resolution;Respondent;Sampling;Secure;Site;smartphone application;Specificity;Standardization;System;Techniques;technology intervention;technology platform;telehealth;Testing;Time;tool;Training;training data;Tuberculosis;tuberculosis treatment;Uganda;United States National Institutes of Health;uptake;Validation;Visual;Water;Workload

PROJECT_TITLE: AI-MedWise: Developing and validating an artificial intelligence solution for effective video-based monitoring of medication adherence

STUDY_SECTION: CIDH

STUDY_SECTION_NAME: Clinical Informatics and Digital Health Study Section[CIDH]


NIH_SPENDING_CATS: Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Patient Safety;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health;Telehealth

PHR: PROJECT NARRATIVE Currently, 41% of Hispanics (34.2 million persons) have below basic health literacy (HL) levels, and, when combined with multiple burdens of chronic diseases such as type 2 diabetes (T2D), this negatively impacts adherence to treatment. The goal of the proposed project is to create a culturally adapted digital health app that will empower older Hispanics with T2D to improve medication adherence and manage their illness by providing tailored, accurate information on T2D, self-management options, and knowledge on prescribed medications while directly involving pharmacists providing them comprehensive medication management. The results of this project will not only lead to a sustained, powerful influence on T2D management, but will also provide a foundational framework for ubiquitous application to different diseases, languages, and cultures that can be leveraged by various healthcare providers to provide comprehensive medication management in a systematic and efficient manner.

PI_NAMEs: CABALLERO, JOSHUA  (contact)

PROGRAM_OFFICER_NAME: SERRANO, KATRINA JANE

PROJECT_TERMS: Address;Adherence;Adult;Age;Age Years;Agreement;barrier to care;burden of chronic illness;care systems;Caring;Cellular Phone;Chronic Disease;Clinical;Clinical Pharmacists;Computers;cost effective;Counseling;culturally appropriate intervention;Data;Development;diabetes management;Diabetes Mellitus;digital;digital applications;digital health;digital technology;Disease;Disparity population;Drug Prescriptions;Education;empowerment;Ensure;Ethnic Origin;fasting glucose;Federally Qualified Health Center;Feedback;follow-up;Funding;Glycosylated hemoglobin A;Goals;Health;health application;health assessment;Health Care Costs;health literacy;Health Personnel;Health Services Accessibility;Healthcare;Hispanic;Hispanic Populations;Hospitalization;Impairment;improved;Individual;Intervention;Knowledge;Language;Lead;low health literacy;Measures;medication compliance;Medication Management;medication nonadherence;Mental Health;Methods;minority patient;Modeling;Modernization;Neighborhood Health Center;Non-Insulin-Dependent Diabetes Mellitus;Not Hispanic or Latino;Outcome;Outpatients;Participant;Patient Care;Patient Monitoring;patient population;Patient Recruitments;Patients;personalized approach;Persons;Pharmaceutical Preparations;Pharmacists;pilot test;pragmatic trial;prototype;Race;Reporting;Role;Secure;Self Management;skills;success;System;Technology;Testing;Time;treatment adherence;treatment planning;United States National Institutes of Health;usability;Visit

PROJECT_TITLE: Development of a Culturally Adapted Digital Health Application for Older Hispanics with Type 2 Diabetes

STUDY_SECTION: CMGC

STUDY_SECTION_NAME: Clinical Management in General Care Settings Study Section[CMGC]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Eye Disease and Disorders of Vision;Gene Therapy;Genetics;Immunotherapy

ORG_CITY: WORCESTER

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: Project Narrative  The third leading cause of blindness is uveitis or ocular inflammation. This proposal will develop a novel treatment for ocular inflammation.

PI_NAMEs: LEE, DARREN JAMES (contact)

PROGRAM_OFFICER_NAME: MCKIE, GEORGE ANN

PROJECT_TERMS: Adrenal Cortex Hormones;Age related macular degeneration;Antigens;Autoimmune;Autoimmune Diseases;autoimmune uveitis;B-Cell Lymphomas;B-Lymphocytes;Biological Assay;Blindness;Bystander Suppression;Capsid;CD19 gene;CD28 gene;Cells;chimeric antigen receptor;chimeric antigen receptor T cells;Chronic;Collaborations;Dependovirus;design;Development;Diabetic Retinopathy;Disease;Disease remission;effective therapy;efficacy evaluation;Engineering;experience;Eye;Eye diseases;FDA approved;Foundations;FOXP3 gene;gene therapy;Hand;Human;human model;Immune response;Immune system;Immunity;Immunology;Infection;Inflammation;Inflammatory;inflammatory milieu;Injections;innovation;interstitial retinol-binding protein;Lupus;Mediating;Methods;mouse model;Mus;novel;novel therapeutics;Ocular cicatricial pemphigoid;Patients;Pharmaceutical Preparations;Phenotype;Predisposition;prevent;promoter;Publishing;Regulatory T-Lymphocyte;Relapse;Resistance;Resolution;Retinal Diseases;Satellite Viruses;Scleritis;side effect;Spleen;Structure;Systemic Lupus Erythematosus;T-Lymphocyte;T-Lymphocyte Subsets;targeted treatment;Testing;Therapeutic;transcription factor;treatment strategy;United States;Uveitis;uveoretinitis;Work

PROJECT_TITLE: Chimeric antigen receptor (CAR) Tregs for treatment of ocular inflammatory diseases

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 1 Study Section[PED1]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Mental Illness;Prevention;Racial and Ethnic Minority Health Research;Schizophrenia;Serious Mental Illness;Social Determinants of Health

ORG_NAME: NEW YORK UNIVERSITY

PHR: Project Narrative Small and low-quality social networks are established risk factors for poor health behaviors, morbidity, and early mortality in the general population and for recognized health disparity populations, such as individuals with serious mental illnesses and racial/ethnic minority individuals. In a sample of 600 Black and Latinx individuals with serious mental illnesses assessed at baseline, 9-months, and 18-months, the proposed mixed methods study will investigate which risk and protective factors, such as social cognition, substance use, racism, stigma, incarceration, or housing are associated with social networks over time and if social networks in-turn are associated with various mental health services outcomes. Findings from this study will be used to develop culturally nuanced interventions for Black and Latinx individuals with serious mental illnesses, whose experiences with racism, stigma and discrimination make them especially vulnerable to social network deterioration and consequent poor health and mental health outcomes.

PI_NAMEs: KELLY, ERIN ;PAHWA, ROHINI  (contact)

PROGRAM_OFFICER_NAME: LEITMAN, DAVID ISAAC

PROJECT_TERMS: Adverse effects;Affect;biopsychosocial factor;Black Populations;Black race;burden of illness;care systems;Cigarette;Clinical;clinical risk;Cognitive deficits;community collaboration;community partners;Complex;culturally appropriate intervention;design;Deterioration;Discrimination;Dropout;Elements;ethnic minority population;Ethnic Origin;Ethnic Population;experience;General Population;Goals;Health;Health behavior;health determinants;health disparity populations;Hospitalization;Housing;Imprisonment;improved;Individual;Inequality;innovation;Institutional Racism;Intervention;Interview;Latinx;Latinx population;Los Angeles;Major Depressive Disorder;Maps;Measures;Mediating;Mental Depression;Mental disorders;Mental Health;Mental Health Services;Methodology;Methods;Modeling;Morbidity - disease rate;mortality;Motivation;National Institute of Mental Health;Outcome;Participant;peer;Personal Satisfaction;physical conditioning;practice-based research network;Predictive Factor;Predisposition;prospective;protective factors;Race;racial minority;racism;Recovery;recruit;Research;Research Personnel;Resources;Risk;Risk Factors;Sampling;satisfaction;Schizophrenia;Self Efficacy;service engagement;Services;severe mental illness;Smoking;social;social cognition;social factors;Social isolation;Social Network;social stigma;Social support;Structural Racism;Structure;substance use;Surveys;Testing;therapy development;Time;Vulnerable Populations;Work

PROJECT_TITLE: A longitudinal examination of factors predicting the social networks and mental health services of Black and Latinx Individuals with serious mental illnesses

STUDY_SECTION: SPIP

STUDY_SECTION_NAME: Social Psychology, Personality and Interpersonal Processes Study Section[SPIP]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: RENO

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF NEVADA RENO

ORG_STATE: NV

PHR: NARRATIVE: In the United States, Black infants experience a 3.7-times higher risk of preterm birth and 2.1-times higher risk of low birth weight than White infants, with racialized inequities widest among high-SES mothers and recent evidence suggesting comparably wide Black-White inequities in maternal mental health risks post-childbirth. Based on preliminary findings suggesting that early-life contexts may play a significant yet understudied role, the proposed research project is aimed at uncovering how social contextual stressors over the maternal pre- pregnancy life course contribute to maternal and infant health and the racialized inequities in the United States. Results from this project may improve our understanding of the biosocial pathways connecting social contex- tual stress, protective factors, and related racialized health inequities over the life course and intergeneration- ally, which may inform preventative policy and public health measures.

PI_NAMEs: KONING, STEPHANIE MICHELLE (contact)

PROGRAM_OFFICER_NAME: CHINN, JUANITA JEANNE

PROJECT_TERMS: Acceleration;Acute;Adolescence;Adolescent;adolescent woman;Adult;Affect;Age;age acceleration;age related decline;Aging;Back;Behavioral;Biological Markers;biopsychosocial;Biosocial;Birth;Birth Weight;Black race;black women;Buffers;Childbirth;Childhood;Chronic;Chronic stress;cohesion;cohort;Collaborations;Collection;Coping Skills;Data;Data Collection;Development;Discrimination;Early identification;early-life disadvantage;epigenetic marker;experience;Exposure to;Female Adolescents;Fostering;Future;Generations;girls;Goals;Health;health equity;health inequalities;healthy pregnancy;high risk;Household;improved;Inequity;Infant;Infant Health;innovation;intergenerational;Intervention;Life;Life Cycle Stages;Link;Longitudinal cohort;Longitudinal Studies;Low Birth Weight Infant;Maternal and Child Health;maternal depression;Maternal Health;maternal outcome;maternal stress;Measures;Mental Health;Mothers;National Institute of Child Health and Human Development;National Longitudinal Survey of Adolescent to Adult Health;novel;Outcome;outcome disparities;Outcome Measure;Pathway interactions;Physiological;Play;Policies;Pregnancy;Premature Birth;prenatal;prepregnancy;Process;prospective;protective factors;psychosocial;Public Health;Race;racial disparity;Regulation;Research Project Grants;Risk;Risk Factors;Role;Safety;Sampling;Schools;secondary analysis;Shapes;social;Social Development;social disparities;Social Environment;social relationships;social stress;social stressor;Stress;Stress and Coping;stressor;Structural Racism;Time;United States;Violence;White Women;Youth

PROJECT_TITLE: Racialized inequities in birth outcomes and maternal health following childbirth: the role of maternal early-life disadvantage, adolescent contexts, and pre-pregnancy stress

STUDY_SECTION: SEDH

STUDY_SECTION_NAME: Social and Environmental Determinants of Health Study Section[SEDH]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Liver Disease;Substance Misuse

ORG_CITY: LOUISVILLE

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF LOUISVILLE

ORG_STATE: KY

PHR: Chronic alcohol consumption can cause alcohol associated liver disease (ALD) which is one of the leading causes of liver disease. We will use mouse models to explore the changes of RNA modification in the mouse livers to uncover the molecular mechanisms of ALD.

PI_NAMEs: HE, LIQING  (contact)

PROGRAM_OFFICER_NAME: PERRUCCIO, ELIZABETH M

PROJECT_TERMS: Acetaldehyde;Affect;Alcohol consumption;alcohol effect;Alcoholic Liver Diseases;Alcohols;Aliquot;Back;base;bioinformatics infrastructure;Biological;Cell Line;cell type;Cells;Chemicals;Chronic;chronic alcohol ingestion;chronic liver disease;Complex;Data;Databases;Detection;Development;Ensure;Enzymes;Etiology;Exhibits;experience;Feces;feeding;gel electrophoresis;Genetic Transcription;Hepatocyte;Human;human disease;Immunohistochemistry;insight;Laboratories;liquid chromatography mass spectrometry;Liver;Liver diseases;Liver Extract;Location;Maps;Messenger RNA;Modification;Molecular;mouse model;Mus;nanopore;National Institute on Alcohol Abuse and Alcoholism;Nature;NMR Spectroscopy;novel;Nuclear Magnetic Resonance;Nucleosides;Oligonucleotides;Organ;Pathogenesis;Pathogenicity;Pathology;Patients;Positioning Attribute;Procedures;Proteomics;Resolution;Ribonucleosides;Ribosomal RNA;RNA;RNA Degradation;RNA Sequences;Role;Serum;Site;Source;Techniques;Technology;transcriptome sequencing;Transfer RNA;two-dimensional;Untranslated RNA;Urine;Variant;Western Blotting

PROJECT_TITLE: RNA Modification Changes in Alcohol-Associated Liver Disease

STUDY_SECTION: AA

STUDY_SECTION_NAME: Biomedical Research Study Section[AA-1]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: AMES

ORG_NAME: IOWA STATE UNIVERSITY

ORG_STATE: IA

PHR: PROJECT NARRATIVE Antimicrobial resistance has become a global threat to public health with annual deaths expected to grow above 10 million by 2050. The proposed research will develop a rapid antibiotics susceptibility test using a MALDI-TOF instrument commonly available in clinical labs. By incubating bacteria with heavy water (D2O) and antibiotics, its resistance can be measured with a minimal turn-around-time, allowing prompt prescription of the most appropriate antibiotics and reducing overuse.

PI_NAMEs: BELLAIRE, BRYAN H;LEE, YOUNG-JIN  (contact)

PROGRAM_OFFICER_NAME: RITCHIE, ALEC

PROJECT_TERMS: Acceleration;Acinetobacter;Adopted;Adoption;Agar;Anti-microbial susceptibility;Antibiotic susceptibility;Antibiotics;Antimicrobial Resistance;Bacteria;bacterial resistance;Biological;Biological Assay;Biological Markers;Biotechnology;Capital;Cessation of life;Clinical;Combined Antibiotics;COVID-19 pandemic;Deuterium;Deuterium Oxide;Development;DNA biosynthesis;Enterobacter;Enterococcus;Escherichia coli;FDA approved;Genus staphylococcus;Gold;Growth;Health;Hour;Human;in vivo;in-vitro diagnostics;Incubated;innovation;instrument;Investments;Isotope Labeling;Klebsiella;Label;Legal patent;lipid biosynthesis;Lipids;Manuscripts;mass spectrometer;Mass Spectrum Analysis;Measures;Metabolic;methicillin resistant Staphylococcus aureus;Methods;microbial;Minimum Inhibitory Concentration measurement;molecular diagnostics;molecular mass;Monitor;Morphology;Multi-Drug Resistance;Multiple Bacterial Drug Resistance;next generation;Nucleic Acids;pathogen;Patients;Protein Biosynthesis;protein degradation;Protocols documentation;Pseudomonas;Public Health;rapid detection;Reporting;Research;Resistance;resistance mechanism;response;Risk;Science;specific biomarkers;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;success;Testing;Time;tool;United States

PROJECT_TITLE: Deuterium Labeling Mass Spectrometry for Rapid Antimicrobial Susceptibility Testing

STUDY_SECTION: EBIT

STUDY_SECTION_NAME: Enabling Bioanalytical and Imaging Technologies Study Section[EBIT]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: SAINT LOUIS

ORG_DEPT: PSYCHOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Alzheimer’s Disease (AD) is an incurable neurodegenerative condition that causes immense human suffering and economic burden that may be especially pernicious for Latinx older adults. The proposed research will examine the feasibility and effectiveness of a new mindfulness training program designed specifically for this community, in terms of its ability to reduce the risk for AD by enhancing cognitive health and psychological well- being. This project directly addresses a major public health prerogative and holds high impact potential to yield valuable new tools for mitigating the risk of AD in communities that may be particularly vulnerable.

PI_NAMEs: BRAVER, TODD S (contact);PARRA PEREZ, DIANA CELMIRA

PROGRAM_OFFICER_NAME: TREVINO, MELISSA

PROJECT_TERMS: access disparities;Accounting;Address;Age;Age-associated memory impairment;age-related disease;Aging;Alzheimer associated neurodegeneration;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Alzheimer’s disease biomarker;Amyloid beta-Protein;Area;Attention;attentional control;Awareness;Behavior;Behavioral;Biological Assay;Biological Markers;Blood;Brain;Chronic stress;Cognitive;Cognitive aging;cognitive enhancement;cognitive function;cognitive neuroscience;cognitive task;Communities;community partnership;Control Groups;cost;Cultural Sensitivity;Data;Dementia;design;Disease;Disparity;Ecological momentary assessment;Economic Burden;economic cost;Educational Curriculum;Effectiveness;Electroencephalography;ethnic minority population;Exhibits;experience;Experimental Designs;Focus Groups;forging;Fostering;Goals;group intervention;Health;health care availability;health care disparity;high risk;Human;Immigrant community;improved;indexing;Individual;innovation;Intervention;intervention program;Language;Latinx;Latinx population;Learning;Life;lifestyle intervention;Link;Measures;Mental Depression;Methods;mindfulness;mindfulness meditation;Mindfulness Training;mindfulness-based stress reduction;Minority Groups;Mission;mobile application;Monitor;Nerve Degeneration;neural;Neurocognitive;novel;older adult;Outcome;Participant;participant retention;Patient Self-Report;Performance;Phase;Phase I Clinical Trials;Plasma;Population;Postdoctoral Fellow;pre-clinical;Prevalence;prevent;programs;Protocols documentation;psychologic;Psychometrics;Public Health;public health intervention;Questionnaires;recruit;Recurrence;Research;response;Risk;Risk Factors;risk mitigation;Risk Reduction;Role;Sampling;Science;skills;Spanish;specific biomarkers;Standardization;Symptoms;tau Proteins;Testing;tool;Training Programs;Translating;Translations;United States;Vulnerable Populations;Waiting Lists;Well in self

PROJECT_TITLE: Mindfulness to Enhance Cognitive Health in Latinx Older Adults at Risk for Alzheimer's Disease

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Emerging Infectious Diseases;Genetics;Human Genome;Infectious Diseases;Lung;Rare Diseases;Tuberculosis

PHR: Project Narra�ve This study integrates new approaches in single cell RNA-sequencing and genomics to gain insight into the pathophysiology and immune response of tuberculosis (TB)—a WHO global health emergency since 1993. This study will characterize the gene�c variants associated with speciﬁc immune cell responses in latent TB controls and recently ac�vated TB cases, contribu�ng immunogene�c proﬁles and datasets relevant in therapeu�c research and vaccine development.

PROGRAM_OFFICER_NAME: EICHELBERG, KATRIN

PROJECT_TERMS: Adaptive Immune System;Address;Admixture;Adult;Affect;Aftercare;Area;Asian ancestry;Biological Assay;Cause of Death;Cell Aggregation;Cell Surface Proteins;cell type;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Centenarian;co-infection;Code;Color;Communicable Diseases;Complex;cost;Data;Data Set;differential expression;Disease;Disease Progression;Epidemiology;European;Event;Exhibits;Exposure to;follow-up;Functional disorder;Funding;Gene Expression;Genes;Genetic;genetic architecture;Genetic Predisposition to Disease;genetic variant;Genetic Variation;genome sequencing;Genomics;Genotype;global health emergency;Grant;Heterogeneity;Heterozygote;Human;Immune;Immune response;Immunogenetics;Immunologics;improved;In Vitro;Incidence;Individual;Infection;Innate Immune System;insight;Interferon Type II;Linkage Disequilibrium;Maps;Measures;Medical;Methods;Modeling;multimodality;Multiomic Data;Mycobacterium tuberculosis;Non-Insulin-Dependent Diabetes Mellitus;novel;novel strategies;Outcome;Participant;pathogen exposure;Peripheral Blood Mononuclear Cell;Phenotype;Population;Population Heterogeneity;Prevalence;Process;protein expression;Quantitative Trait Loci;recruit;Research;research and development;Research Design;Research Infrastructure;response;Sampling;single-cell RNA sequencing;South Africa;South African;South Asian;southeast Asian;study population;Technology;transcriptome sequencing;transcriptomics;Tuberculosis;tuberculosis treatment;Untranslated RNA;vaccine development;Vaccines;Variant;whole genome;Work

PROJECT_TITLE: Integrating single-cell omics and ancestry-adjusted eQTL mapping to characterize Tuberculosis immune response


ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative Even when severe, SLE may go into remission that can last for months or even years. The proposed studies will investigate a novel hypothesis that involves the role of Izumo1 in remission in SLE. If successful, this proposal may identify the first biomarker and potential therapy linked to the induction of remission in SLE.

PI_NAMEs: ANDRADE, FELIPE  (contact)

PROGRAM_OFFICER_NAME: RICE, JEFFREY S

PROJECT_TERMS: anergy;Anti-Inflammatory Agents;Attenuated;Binding;Biological Markers;Blood;CD4 Positive T Lymphocytes;Cells;Chronic;chronic autoimmune disease;Chronic Disease;Circulation;Clinical;cohort;Data;delta receptors;Disease;Disease Marker;Disease remission;egg;extracellular;Fertilization;Flare;folate-binding protein;FOXP3 gene;Genes;Genetic Transcription;Goals;Helper-Inducer T-Lymphocyte;Immunoglobulin Domain;In Vitro;Inflammation;insight;Interferons;Japanese;Laboratories;Ligands;Link;Lupus;Maintenance;Marriage;Membrane Proteins;Mus;mutant;Names;novel;novel therapeutic intervention;Patients;Peripheral Blood Mononuclear Cell;Plasma;Play;Process;prospective;Prospective cohort;Proteins;receptor;Recombinants;Recurrent disease;Regulatory Pathway;Regulatory T-Lymphocyte;Remission Induction;Role;Severities;Skin;sperm cell;Symptoms;Systemic Lupus Erythematosus;Therapeutic;γδ T cells

PROJECT_TITLE: Izumo1 in remission in SLE

STUDY_SECTION: HAI

STUDY_SECTION_NAME: Hypersensitivity, Autoimmune, and Immune-mediated Diseases Study Section[HAI]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Chronic Obstructive Pulmonary Disease;Climate-Related Exposures and Conditions;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Effects of Household Energy Combustion;Health Effects of Indoor Air Pollution;Lung;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_NAME: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR

PHR: Successful completion of this study will greatly advance our understanding of racial-ethnic disparities in lung dose and toxicity of PM exposure, which is critical for identifying drivers of racial-ethnic disparities in PM induced health effects. This study will also stress the consideration of racial-ethnic disparity in levels and toxicity of PM2.5 exposures when tightening the National Ambient Air Quality Standards.

PI_NAMEs: LENG, SHUGUANG  (contact)

PROGRAM_OFFICER_NAME: POSTOW, LISA

PROJECT_TERMS: Affect;Age;aged;Air;airway obstruction;Algorithms;American;Area;Artificial Intelligence;Biological Assay;Biological Markers;Biomass;Black American;Black Populations;Black race;Blood;Breathing;Carbon;Carbon Black;caucasian American;chemokine;Chronic Obstructive Pulmonary Disease;climate change;cohort;cytokine;Deposition;Disease Outcome;Dose;Enrollment;ethnic difference;ethnic disparity;Ethnic Origin;experience;Exposure to;Female;fine particles;Fossil Fuels;Frequencies;Funding;Genetic;Geography;Health;health disparity;Health Status;Housing;Individual;Industry;Inflammatory;Inhalation Exposure;innovation;Institutional Racism;Knowledge;Literature;Longitudinal Studies;Lung;lung injury;Machine Learning;machine learning algorithm;Macrophage;male;Methods;National Heart, Lung, and Blood Institute;Neighborhoods;non-smoker;novel;Observational Study;Outcome;particle;Particulate Matter;Pathway interactions;Pattern;people of color;Plasma;Policies;Process;Public Health;Pulmonary Inflammation;Race;racial difference;racial disparity;Reporting;response;sex;Smoker;Smoking Status;social health determinants;Source;Sputum;Sputum Cytology Screening;Statistical Models;Stress;systemic inflammatory response;Testing;Toxic effect;Translating;United States

PROJECT_TITLE: Lung deposition dose of black carbon as a driver of health Disparities

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-K (J1)]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Contraception/Reproduction;Dietary Supplements;Heart Disease;Microbiome;Nutrition;Obesity;Polycystic Ovary Syndrome (PCOS);Prevention;Women's Health Research

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative This research project has particular relevance for women with polycystic ovary syndrome (PCOS) which is the most common endocrine disorder in reproductive-aged women worldwide. In addition to infertility and pregnancy complications, women with PCOS often present with obesity, insulin resistance and dyslipidemia that result in chronic comorbidities which include type 2 diabetes and cardiovascular disease. Understanding how treatment with resistant starch influences cardiometabolic function and the gut microbiome in PCOS may provide a pragmatic, low-cost treatment for women with this disorder specifically in women receiving first-line therapy of oral contraceptives and reveal if modulation of the microbiome provides novel therapeutics options for PCOS.

PI_NAMEs: DOKRAS, ANUJA  (contact)

PROGRAM_OFFICER_NAME: VARAGIC, JASMINA

PROJECT_TERMS: Affect;Age;aged;Androgens;arm;Bifidobacterium;Biological Markers;Blood Pressure;Body fat;Body mass index;cardiometabolic risk;cardiometabolism;Cardiovascular Diseases;cardiovascular disorder prevention;cardiovascular disorder risk;Chronic;comorbidity;Consumption;cost;Counseling;Data;Development;dietary;Dietary Fiber;dietary supplements;Disease;Double-Blind Method;Dyslipidemias;Economic Burden;Endocrine System Diseases;Enrollment;Event;Exposure to;fasting glucose;Fatty Change;FDA approved;fecal transplantation;Functional disorder;General Population;Genes;Glucose;gut bacteria;gut dysbiosis;gut health;gut microbes;gut microbiome;gut microbiota;healthcare burden;High Prevalence;high risk;high risk population;Hyperandrogenism;Hypertension;improved;Individual;Infertility;Inflammation;inflammatory marker;innovation;insight;Insulin Resistance;Intake;interest;Knowledge;lifestyle intervention;Lipids;maltodextrin;Metabolic;metabolomics;Metagenomics;microbial;microbiome;mortality;mouse model;Non-Insulin-Dependent Diabetes Mellitus;Nonpharmacologic Therapy;novel;novel therapeutics;Nutritional Support;Obesity;Oral Contraceptives;Overweight;Pathway interactions;Patients;pharmacologic;Phenotype;pill;Placebo Control;Placebos;Play;Polycystic Ovary Syndrome;Population;Pregnancy Complications;pregnancy disorder;Prevention;randomized placebo-controlled clinical trial;randomized, clinical trials;Recommendation;Reporting;reproductive;Research Project Grants;Resistance;response;Risk;Risk Factors;Rodent Model;Role;Serum;standard care;Starch;Supplementation;Surveys;Testing;Testosterone;Treatment Cost;Volatile Fatty Acids;Woman;women's clinical trial;women's treatment

PROJECT_TITLE: Resistant starch treatment of polycystic ovary syndrome: impact on cardiometabolic dysfunction and the gut microbiome

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-J (96)]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Chronic Pain;Clinical Research;Pain Research

ORG_CITY: BLACKSBURG

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

ORG_STATE: VA

PHR: A pulse-driven micropump for transdermal drug delivery PROJECT NARRATIVE Ambulatory infusion pumps allow millions of patients to go about their daily lives while receiving potentially lifesaving infusions of parenteral nutrition, chemotherapy, postoperative pain medication, and IV antibiotics, but they are bulky, usually connected to the patient via tubing, conspicuous, and can involve pain at the access site, which are the primary self-reported reasons that insulin users, for example, don’t adhere to their insulin regimes. To address these challenges, we developed a featherweight, pulse-driven micropump a fraction of the size of current battery-and-motor driven infusion pumps. Widespread adoption of this minimal, biology-mimicking, pulse- driven pump technology in infusion devices would dramatically shrink their footprint, lowering barriers to ambulatory infusion therapy adherence and transforming the quality of life for patients needing infusions.

PI_NAMEs: STAPLES, ANNE  (contact)

PROGRAM_OFFICER_NAME: FALCONE, JESSICA

PROJECT_TERMS: 3-Dimensional;3D Print;Address;Adherence;Adoption;Adult;Algorithms;Analgesics;Antibiotic Therapy;Antibiotics;Automobile Driving;Biological;Biological Process;Biology;Blood Pressure;cancer therapy;Cannulas;Cessation of life;Characteristics;chemotherapy;Chronic;Clinical;clinical application;Computer Models;cost;Coupled;Data;Dependence;design;Development;Device Designs;Devices;Diabetes Mellitus;diabetic;Drug Delivery Systems;elastomeric;Elastomers;Elements;experimental study;fabrication;Family suidae;flexibility;Future;Gel;Goals;Heart Rate;Human;human subject;Hyperglycemia;Implant;Implantable Pump;improved;in silico;In Vitro;in vivo;in vivo evaluation;indexing;Infusion procedures;Infusion Pumps;Injections;innovation;Insecta;Insulin;Insulin Infusion Systems;interstitial;Left;Life;light weight;Liquid substance;Malignant Neoplasms;Measures;Medical Device;Microfluidics;Modality;Modeling;Motor;Needles;next generation;nicotine patch;Outcome;Outpatients;Pain;Pain management;parenteral administration;Parenteral Nutrition;Patient Care;Patient Self-Report;Patient-Controlled Analgesia;Patients;Periodicals;Pharmaceutical Preparations;Physical activity;Physics;Physiologic pulse;Postoperative Pain;prototype;Pump;Quality of life;radial artery;Regimen;Reporting;Research;Resistance;Respiration;response;Risk Reduction;Self Administration;Site;Skin;standard of care;Statistical Models;Surface;System;Techniques;Technology;Testing;Therapeutic;therapy adherence;tool;Transdermal substance administration;Tube;Vaccines;wearable device

PROJECT_TITLE: A pulse-driven micropump for continuous drug delivery

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BBBT-M (82)]