NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Osteoporosis;Pediatric;Physical Activity;Prevention

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Gender-affirming medical therapy for transgender and gender diverse youth can be initiated in early puberty with gonadotropin-releasing hormone agonists for puberty suppression, but there are sparse data on skeletal outcomes of early pubertal suppression and subsequent peer-concordant puberty-timing of gender-affirming sex hormones. Because puberty is a critical time period for skeletal growth and mineralization, gender- affirming medical therapy is introduced during a particularly vulnerable window. Understanding how bone mass develops as gender-affirming sex steroids are introduced following puberty suppression, in the context of important determinants of bone development such as physical activity, body composition, and muscle strength, will fill a critical knowledge gap and potentially improve current treatment protocols, as future studies further characterize these skeletal trajectories into young adulthood.

PI_NAMEs: LEE, JANET YI MAN (contact)

PROGRAM_OFFICER_NAME: WINER, KAREN

PROJECT_TERMS: 14 year old;Accelerometer;Adolescent;Age;age related;Agonist;Architecture;Area;Attenuated;Biomechanics;Birth;Body Composition;Body mass index;bone;bone age;Bone Density;Bone Development;bone geometry;bone health;bone mass;bone strength;bone turnover;calcium intake;Caring;Chronology;Clinical;cohort;Cohort Studies;Complex;Data;Data Analyses;density;Dietary Calcium;Distal;Dual-Energy X-Ray Absorptiometry;Endocrinology;Enrollment;Evaluation;Failure;Fatty acid glycerol esters;Female;Finite Element Analysis;Fracture;fracture risk;Funding;Future;Gender;gender affirmation;gender diverse;Gender Identity;Goals;Gonadal Steroid Hormones;Gonadotropin Hormone Releasing Hormone;grasp;Growth;Hand;Hand Strength;Health;Hormones;Impairment;improved;indexing;Intervention;Intervention Studies;Investigation;Isometric Exercise;Knee;Knowledge;late life;lean body mass;Longitudinal Studies;male;Measures;Medical;Medicine;Mentors;mineralization;Modeling;Muscle;muscle form;muscle strength;Outcome;Participant;peer;Peripheral;Physical activity;Physicians;Population;Populations at Risk;Positioning Attribute;prevent;prospective;Prospective Studies;pubertal timing;Puberty;puberty blocker;Publishing;Radial;Recovery;Research;Resolution;Risk;Scanning;Scientist;sedentary;sex;Site;skeletal;Skeletal Development;skills;Technology;Teenagers;Testing;Thick;Thigh structure;tibia;Time;Training;transfeminine;transgender;transmasculine;treatment optimization;Treatment Protocols;United States;Weight-Bearing state;X-Ray Computed Tomography;young adult;Youth

PROJECT_TITLE: Skeletal effects of early pubertal suppression and peer-concordant puberty timing in transgender and gender diverse youth

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Pediatrics Study Section[CHHD-A]


ADMINISTERING_IC: MH

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;HIV/AIDS;Health Services;Infectious Diseases;Mental Health;Prevention;Sexually Transmitted Infections

ORG_CITY: CAPE TOWN

ORG_COUNTRY: SOUTH AFRICA

ORG_FIPS: SF

ORG_NAME: DESMOND TUTU HIV FOUNDATION

PHR: PROJECT NARRATIVE Men living with HIV are significantly less likely than women to know their HIV status, initiate anti-retroviral therapy, and achieve viral suppression, particularly in South Africa. Furthermore, while there is growing knowledge of the Undetectable Equals Untransmittable (U=U) concepts in Western and high-income countries, the reach and penetration of the U=U message in sub-Saharan Africa has been limited. Our rigorous evaluation of interventions that incorporate U=U messages for cis-gender men in a high HIV prevalence setting will provide critical information to inform the implementation of HIV testing and ART adherence counseling guidelines in South Africa and globally, ultimately accelerating the decline in HIV incidence among women, improving men's HIV-related health outcomes, and improving the likelihood of achieving UNAIDS 95-95-95 goals by 2030.

PI_NAMEs: BUTTENHEIM, ALISON MEREDITH;MEDINA-MARINO, ANDREW  (contact)

PROGRAM_OFFICER_NAME: GREENWOOD, GREGORY LOUIS

PROJECT_TERMS: Acceleration;Achievement;Acquired Immunodeficiency Syndrome;Address;Adherence;Adoption;Africa South of the Sahara;AIDS prevention;antiretroviral therapy;anxiety reduction;Area;behavioral economics;Behavioral Sciences;Caring;cis-male;Clinic;clinical practice;Collaborations;Communicable Diseases;Communication;Communities;contextual factors;Continuity of Patient Care;Counseling;Country;Coupled;Data;Effectiveness;effectiveness evaluation;Effectiveness of Interventions;effectiveness-implementation RCT;Epidemic;Epidemiology;Evaluation;experience;Fright;future implementation;Gender;Goals;Government;Guidelines;Health;Health Benefit;High Prevalence;HIV;HIV Infections;HIV Seropositivity;human centered design;Human immunodeficiency virus test;implementation barriers;implementation efforts;implementation facilitation;improved;Incidence;Income;innovation;insight;Institution;Intervention;Knowledge;Learning;male health;men;Methods;mortality risk;Outcome;Participant;peer;Penetration;Persons;Prevalence;primary outcome;Process;prototype;Province;Randomized;randomized trial;Research;Resources;Safe Sex;secondary outcome;service delivery;service uptake;sexual HIV transmission;Sexual Partners;Shapes;Site;South Africa;standard of care;successful intervention;Testing;testing services;testing uptake;theories;therapy adherence;tool;transmission process;treatment adherence;treatment as prevention;Unsafe Sex;uptake;Viral;Viral Load result;Woman;women versus men;Work;yeast two hybrid system

PROJECT_TITLE: Improving HIV testing, linkage, and retention in care for men through U=U messaging

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Data Science;Infectious Diseases;Machine Learning and Artificial Intelligence;Malaria;Networking and Information Technology R&D (NITRD);Rare Diseases;Vector-Borne Diseases

ORG_CITY: BALTIMORE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Machine learning-based computer vision technology can supplement or even supplant some of the traditional benchtop methods that malariologists currently rely on for interrogating the biology of Plasmodium, a persistant cause of death and disease in much of the tropical and sub-tropical world where one-third of the world population resides. Microscopy-based methods may seem on the surface mundane or archaic, but they remain a crucial clinical and investigative tool for malaria where a tissue “biopsy” is as simple as a prick of the finger. We aim to modernize microscopy applications in basic science and pre-clinical malaria research by leveraging recent advances in computer vision and artificial intelligence to accelerate and innovate the means by which information is derived from malaria blood smears and, in the process, establish novel methods in weakly- and semi-supervised learning and domain adaptation to overcome key challenges in biomedical image analysis.

PI_NAMEs: HAEFFELE, BENJAMIN D;IPPOLITO, MATTHEW MICHAEL (contact)

PROGRAM_OFFICER_NAME: MCGUGAN, GLEN C

PROJECT_TERMS: Acceleration;Address;Africa South of the Sahara;African;Aftercare;algorithm training;Algorithms;Anti-malarials;Appearance;Artificial Intelligence;Basic Science;Behavior;Biological;Biology;Biomedical Engineering;biomedical imaging;Biopsy;Blood;Breeding;Brightfield Microscopy;Cause of Death;cell injury;Cells;cellular pathology;Cessation of life;Child;Classification;Clinic;Clinical;Collaborations;Color;Communicable Diseases;Computer Vision Systems;Computing Methodologies;Consumption;cost;Data;data acquisition;Data Set;Data Sources;deep learning;deep neural network;Derivation procedure;design;Detection;detection platform;Development;digital;Disease;Drug Exposure;Drug resistance;E-learning;Engineering;Equipment;Erythrocytes;experience;Film;Fingers;Funding Mechanisms;Generations;Genetic Transcription;Grant;Hemolysis;Histologic;Histopathology;Image;Image Analysis;Imaging problem;Immune system;Infection;innovation;International;Label;Laboratories;learning strategy;Life Cycle Stages;life span;light microscopy;Liver;Machine Learning;Malaria;Manuals;medical schools;Methods;microscopic imaging;Microscopy;miniaturize;Modeling;Modernization;Molecular;Monitor;Network-based;neural network;next generation;novel;Outcome;Parasites;Parasitology;Pathology;Performance;Plasmodium;Plasmodium falciparum;Population;pre-clinical;Prediction of Response to Therapy;Predisposition;Preparation;preservation;Principal Investigator;Process;Prognosis;protein expression;protein metabolism;prototype;Public Health;Reproducibility;Research;Research Institute;Research Personnel;Resolution;Running;Science;Semantics;Sepsis;Site;Slide;smart device;Specimen;Spleen;Stains;statistics;success;supervised learning;Surface;Surveys;Techniques;Technology;Time;Tissues;tool;Training;training data;Treatment Efficacy;Universities;Variant;Visual;visual information;Work

PROJECT_TITLE: Computer Vision for Malaria Microscopy: Automated Detection and Classification of Plasmodium for Basic Science and Pre-Clinical Applications


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Clinical Research;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: BOSTON

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

ORG_STATE: MA

PHR: The collective findings from this project aimed at identifying risk and protective genetic factors for Alzheimer disease (AD) in MENA Jews and Arabs, coupled with genetic analyses of AD-related traits and viral DNA, will permit us to develop new hypotheses about pathogenic mechanisms, identify proteins as targets for drug development, and provide genetic and cognitive markers for use in risk assessment and profiling subjects for clinical trials.

PI_NAMEs: FARRER, LINDSAY A. (contact);SHERVA, RICHARD

PROGRAM_OFFICER_NAME: BENNANI-BAITI, MICHAEL

PROJECT_TERMS: Admixture;admixture mapping;Affect;Age;Alzheimer's Disease;Alzheimer's disease risk;Alzheimer’s disease biomarker;Amyloid beta-Protein;analytical method;ancestry analysis;apolipoprotein E-4;Arabs;Ashkenazim;Bioinformatics;Biological Markers;Blood;Blood specimen;Brain;brain magnetic resonance imaging;Caucasians;Clinical;clinical examination;Clinical Trials;Cognitive;cognitive testing;cohort;Coupled;Data;Data Set;Development;DNA;drug development;Drug Targeting;Environmental Exposure;Environmental Risk Factor;Ethnic Origin;Ethnic Population;European ancestry;Evaluation;follower of religion Jewish;Funding;Gene Expression;gene network;Gene Targeting;Genes;Genetic;genetic analysis;genetic architecture;Genetic Diseases;Genetic Drift;Genetic study;genetic testing;Genetic Transcription;genome sequencing;genome wide association study;genome-wide;Genotype;Goals;Haplotypes;Human;Individual;insertion/deletion mutation;Israel;Jews;Joints;Lead;Life Style;Light;Location;machine learning method;Measures;Medical History;Mendelian randomization;Methods;Middle East;Modeling;Modification;Mutation;neurofilament;next generation sequencing;Northern Africa;novel;Nucleotides;Outcome;Participant;Pathogenicity;Pathway Analysis;Pathway interactions;patient registry;Pharmaceutical Preparations;Phenotype;phenotypic data;pleiotropism;Population;positional cloning;Process;prospective;protein structure;Proteins;Quantitative Trait Loci;recruit;Risk;Risk Assessment;risk variant;Role;Sampling;Satellite Viruses;Sequence Alignment;Site;Spain;Specimen;tau Proteins;tau-1;Tissues;trait;United States National Institutes of Health;Variant;viral detection;viral DNA;Virus;whole genome

PROJECT_TITLE: Genetic Studies of Alzheimer's Disease in Jewish and Arab Populations


ADMINISTERING_IC: AA

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Pediatric;Physical Injury - Accidents and Adverse Effects;Prevention;Social Determinants of Health;Substance Misuse;Underage Drinking;Violence Research;Youth Violence;Youth Violence Prevention

ORG_CITY: PROVIDENCE

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: PROJECT NARRATIVE The proposed study will investigate bystander helping in hazardous alcohol situations among young adults. For 28 days participants will complete mobile phone assessments on days that they are exposed to another person’s hazardous alcohol use. This research will provide invaluable information about event- and person- level characteristics that are associated with bystander helping, as well as how the specific helping approaches bystanders use are related to situational outcomes.

PI_NAMEs: BARNETT, NANCY P (contact)

PROGRAM_OFFICER_NAME: KERRIDGE, BRADLEY TOWNSEND

PROJECT_TERMS: Address;Age;age group;Alcohol abuse;alcohol behavior;Alcohol consumption;alcohol exposure;alcohol measurement;alcohol related consequences;alcohol risk;Alcoholic Intoxication;Alcohols;Area;Automobile Driving;Behavior;behavioral response;binge drinking;bullying prevention;Cellular Phone;Characteristics;Cognition;Communities;community engagement;Dangerous Behavior;Dangerousness;Development;drinking;Ecological momentary assessment;Educational Intervention;effective intervention;emerging adult;Environment;Ethnic Origin;Event;experience;Exposure to;Frequencies;Gender;Goals;Harm Reduction;hazardous drinking;Health protection;Heavy Drinking;high risk;high risk behavior;improved;Individual;Individual Differences;Intervention;intervention program;Intervention Studies;Interview;Intoxication;Investigation;Location;Methods;Modeling;Nature;Outcome;Participant;Pattern;peer;peer influence;Perception;Persons;Phase;prevent;Prevention;Privatization;Procedures;programs;prospective;Race;Reporting;Research;response;Risk;Risk Behaviors;Risk Reduction;Safety;Sampling;Self Efficacy;Self-Examination;Severities;sexual assault;social;Social Environment;social influence;Social Network;Surveys;Targeted Research;Time;Training;young adult

PROJECT_TITLE: Characteristics and Contexts of Bystander Helping for Alcohol-Related Risk among Emerging Adults

STUDY_SECTION: SPIP

STUDY_SECTION_NAME: Social Psychology, Personality and Interpersonal Processes Study Section[SPIP]


ADMINISTERING_IC: HD

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Pediatric;Prevention

ORG_CITY: WINSTON-SALEM

ORG_DEPT: SURGERY

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

ORG_STATE: NC

PHR: Project Narrative The Training in Research Affecting Child Health (TRAC) Program takes advantage of the broad, transdisciplinary research established in the area of child health and development at the Wake Forest University School of Medicine. TRAC provides innovative and creative research training to learners across a broad educational spectrum through an 8-week immersive research skills training course in child health that includes a mentored research project and culminates in a presentation at a scientific conference and a co-authored manuscript.

PI_NAMEs: GWATHMEY, TANYA M. (contact);SOUTH, ANDREW MICHAEL

PROJECT_TERMS: Adult;Affect;Area;Behavioral;Bioinformatics;Budgets;career;Career Choice;Child;Child Development;Child Health;child services;Child Support;Child Welfare;Childhood;Clinical;Clinical Research;Collaborations;collaborative environment;Communities;Creativeness;Critical Thinking;Data Scientist;design;Development;Education;education research;Educational process of instructing;Educational Status;empowerment;Environment;Epidemiologist;Epidemiology;Exercise;experience;Exposure to;Extramural Activities;Faculty;faculty mentor;Fostering;Funding;Goals;graduate student;Growth;Health;health disparity;health equity;health inequalities;Health system;Heart Atrium;Historically Black Colleges and Universities;Individual;innovation;Institution;interest;Laboratories;Learning;Life Cycle Stages;Manuscripts;medical schools;Medical Students;meetings;Mentors;Mentorship;Minority-Serving Institution;Mission;Modeling;National Institute of Child Health and Human Development;next generation;novel;nutrition;Occupations;Ownership;Participant;patient engagement;pediatric department;Pediatric Research;pediatrician;peer;peer coaching;Peer Review;Physicians;Population;Positioning Attribute;pre-clinical;Productivity;programs;Publications;Recording of previous events;recruit;Reduce health disparities;reproductive;Research;Research Design;Research Methodology;Research Personnel;Research Project Grants;Research Training;Resources;Science;Scientist;skills;skills training;Social Processes;Societies;success;symposium;Training;training opportunity;Training Programs;undergraduate student;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: The Wake Forest School of Medicine Training in Research Affecting Child-Health (TRAC) Program

STUDY_SECTION_NAME: Health, Behavior, and Context Study Section[CHHD-M]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Patient Safety;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: TAMPA

ORG_NAME: H. LEE MOFFITT CANCER CTR & RES INST

ORG_STATE: FL

PHR: Project Narrative Suboptimal racial/ethnic minority accrual to clinical trials perpetuates significant disparities in cancer care. The overall goal of the proposed research is to refine, implement, and evaluate a multilevel intervention to improve minority referral and enrollment to NCI-sponsored cancer therapeutic clinical trials leveraging digital solutions coupled with navigation by community health educators.

PI_NAMEs: VADAPARAMPIL, SUSAN T (contact)

PROGRAM_OFFICER_NAME: SAN MIGUEL-MAJORS, SANDRA L

PROJECT_TERMS: Address;Area;Attitude;Awareness;Black Populations;Black race;Cancer Burden;cancer care;Cancer Center;cancer health disparity;Cancer Patient;cancer therapy;Caring;Catchment Area;Clinical;clinical trial enrollment;Clinical Trials;Communities;community center;community engaged approach;Community Health;community intervention;Community Outreach;community partnership;Community Physician;Community Practice;community setting;Coupled;dashboard;design;Diagnosis;digital;digital intervention;digital solutions;digital tool;Disparity;Education;Enrollment;Equilibrium;ethnic minority;ethnic minority population;experience;Face;Fostering;Future;Goals;Health Educators;Health system;Hispanic;Hispanic Populations;implementation evaluation;implementation outcomes;implementation science;implicit bias;improved;innovation;interest;Intervention;intervention refinement;Interview;Knowledge;Logistics;Malignant Neoplasms;Measures;medically underserved population;Methodology;Methods;Minority;Minority Enrollment;Minority Participation;minority patient;Modeling;Modification;outreach;Participant;participant enrollment;patient portal;Patients;Pattern;Perception;Phase;Physicians;precision oncology;preference;primary outcome;Process;Qualitative Evaluations;racial minority;racial minority population;Reach, Effectiveness, Adoption, Implementation, and Maintenance;recruit;Research;Site;success;System;Therapeutic Clinical Trial;Time;Translations;Transportation;treatment trial;trial enrollment;Trust;user centered design;willingness

PROJECT_TITLE: Advancing Clinical Trials: Working through Outreach, Navigation and Digital Enabled Referral and Recruitment Strategies (ACT WONDERS)


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: NEW YORK

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: PROJECT NARRATIVE Despite recent progresses in mechanobiology research, there is still a fundamental knowledge gap in critical cellular functions and molecular mechanisms, which take place between the molecular and cellular scale. Combining the state-of-the-art top-down nanotechnology and the bottom-up synthetic biology, we will create artificial cell interfaces with multiplexed physicochemical features to elucidate and direct cellular functions. Considering the interplay and crosstalk between multiple receptors and physicochemical cues, we will reveal the underlying synergistic mechanisms of heteromolecular mechanobiology for cell-extracellular matrix signaling (fibroblast as a model) and cell-cell signaling (T cell as a model).

PI_NAMEs: CAI, HAOGANG  (contact)

PROGRAM_OFFICER_NAME: BARNES, CHARLES ASHLEY

PROJECT_TERMS: 3-Dimensional;Adopted;Behavior;Cell Physiology;Cell surface;Cells;Cellular biology;cellular engineering;Complex;Cues;Environment;Extracellular Matrix;Fibroblasts;Goals;Growth Factor Receptors;In Vitro;in vivo;insight;Integrins;intercellular communication;Knowledge;Laboratories;Ligands;manufacture;mechanotransduction;Mediating;Methodology;Methods;Modeling;Molecular;nanoengineering;Nanotechnology;novel diagnostics;novel therapeutics;receptor;Research;Role;segregation;Signal Transduction;single molecule;Surface;synthetic biology;System;T-Cell Receptor;T-Lymphocyte;Technology

PROJECT_TITLE: Elucidating and Directing Heteromolecular Mechanobiology with Nanoengineered Cell Interfaces

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-M(55)R]


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Immunotherapy;Orphan Drug;Pancreatic Cancer;Rare Diseases

ORG_CITY: DUARTE

ORG_NAME: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE

ORG_STATE: CA

PHR: PROJECT NARRATIVE Pancreatic cancer has a mortality rate approximately equal to its incidence and will soon become the second- leading cause of all cancer-related deaths. High mortality is primarily the result of treatment resistance and, therefore, the current proposal seeks to develop microbial-based, tumor-targeted approaches to diminish the abundance of extracellular matrix components that significantly reduce delivery and efficacy of therapy in pancreatic cancer. Our research is relevant to public health because it is expected to generate approaches that will safely promote tumor permeability and drug perfusion, ultimately enabling anticancer agents to achieve their greatest therapeutic effects in cancer patients.

PI_NAMEs: MANUEL, EDWIN  (contact)

PROGRAM_OFFICER_NAME: RASOOLY, AVRAHAM

PROJECT_TERMS: advanced disease;Antibodies;Antineoplastic Agents;Attenuated;Cancer Etiology;Cancer Patient;cancer therapy;candidate identification;Cessation of life;Characteristics;chemotherapy;Clinical;clinical translation;clinically relevant;Collagen;collagenase;Combined Modality Therapy;comparative efficacy;conventional therapy;cost;Culture Media;Data;Death Rate;density;Deposition;design and construction;Desmoplastic;Developing Countries;Diameter;Distal;Dose;Drug Delivery Systems;Encapsulated;Engineering;Enzymes;Epithelium;experience;Extracellular Matrix;Extracellular Matrix Degradation;Frequencies;Goals;Hyaluronan;Hyaluronic Acid;Hyaluronidase;Immune;immune cell infiltrate;immune checkpoint blockade;Immunotherapy;improved;Incidence;Infiltration;innovation;interstitial;Investigational Drugs;Legal patent;macromolecule;Malignant neoplasm of pancreas;Malignant Neoplasms;Manuals;manufacture;Measures;Mesenchymal;Methods;microbial;mortality;mouse model;Myofibroblast;National Cancer Institute;Neoplasm Metastasis;novel;novel strategies;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma model;Patients;Penetration;Perfusion;Permeability;Pharmaceutical Preparations;Plasmids;Play;pressure;prevent;Primary Neoplasm;Production;promoter;protein expression;Public Health;Publishing;Recombinants;Regenerative capacity;Regimen;remediation;Research;Role;Salmonella;Salmonella typhimurium;Serious Adverse Event;side effect;smoothened signaling pathway;Solid;Solid Neoplasm;standard of care;Surface;Survival Rate;systemic toxicity;Testing;Therapeutic;Therapeutic Effect;therapy resistant;Tissues;Treatment Efficacy;tumor;Tumor Burden;tumor growth;Tumor Promotion;Tumor Tissue;Tumor-infiltrating immune cells;Vascularization;vector;Work

PROJECT_TITLE: Microbial- based targeting of major extracellular matrix components for improved therapy of pancreatic cancer

STUDY_SECTION: DT

STUDY_SECTION_NAME: Developmental Therapeutics Study Section[DT]


NIH_SPENDING_CATS: Cancer;Precision Medicine;Prevention;Prostate Cancer;Radiation Oncology;Urologic Diseases

ORG_CITY: ATLANTA

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: RELEVANCE: The goal of this project is to develop and validate an “integrated risk score” (IRiS) predictor using histomorphometric features derived from digital images of surgically excised tissue specimens and biopsied tissue, that is both prognostic of prostate cancer (PCa) outcome and predictive of added benefit of adjuvant therapy following definitive therapy (surgery OR radiation therapy). IRiS will help to identify which of the over 160,000 men with high-risk prostate cancer in the US and who annually undergo definitive therapy have higher risk disease and hence may receive added benefit from additional chemotherapy following definitive therapy.

PI_NAMEs: GUPTA, SHILPA ;LAL, PRITI ;MADABHUSHI, ANANT  (contact)

PROGRAM_OFFICER_NAME: MCKEE, TAWNYA C

PROJECT_TERMS: Accounting;Adjuvant Therapy;advanced disease;African American;androgen deprivation therapy;Androgen Suppression;Architecture;Biochemical;Biological Assay;Biological Markers;Biopsy;Biopsy Specimen;Cancer Patient;cancer recurrence;caucasian American;Cell Nucleus;Cessation of life;chemotherapy;Clinic;Clinical;Clinical Trials;Collagen;Collagen Fiber;companion diagnostics;Complement;Computer software;computerized;Computers;cost;Country;Cues;Data;Dedications;diagnostic assay;digital;digital imaging;digital pathology;disorder risk;effective therapy;Ethnic Population;Exhibits;follow-up;genetic testing;Genomics;Gland;Gleason Grade for Prostate Cancer;Goals;Guidelines;Habitats;hazard;head-to-head comparison;high risk;high risk population;Image;Image-Guided Surgery;improved;indexing;innovation;Malignant neoplasm of prostate;Malignant Neoplasms;Medical Oncology;men;Modeling;Molecular;Morbidity - disease rate;Morphology;mortality risk;National Comprehensive Cancer Network;Neoplasm Metastasis;Nomograms;Nuclear;Oncology;Operative Surgical Procedures;Organ;Outcome;Paper;Pathologic;Pathology;Patients;Pattern;Pennsylvania;Performance;Phenotype;Population;precision medicine;precision oncology;predictive test;Prognosis;prognostic;prognostic assays;prostate cancer model;prostate cancer risk;Prostate Cancer therapy;prototype;Publishing;Radiation;Radiation therapy;Radiation Therapy Oncology Group;Radical Prostatectomy;randomized, clinical trials;Recurrence;Risk;risk minimization;Risk Reduction;Secure;Site;Slide;Specimen;success;Testing;Time;Tissue imaging;Tissues;tool;Translating;treatment guidelines;tumor;Tumor Tissue;Universities;Validation;Visual

PROJECT_TITLE: Prognostic and Predictive Digital Tissue Image Assay for Prostate Cancer

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Services;Heart Disease;Precision Medicine

ORG_CITY: Aurora

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because the discovery of effective approaches for the design and implementation of computerized clinical decision support (CDS) tools can improve the expeditious translation of evidence into practice; thereby, improve the management of populations of patients and lead to improved patient care and outcomes. This proposed research is relevant to NHLBI's mission because it has the potential to substantially improve guideline-directed management and outcomes for patients with heart failure; it can be expanded to other patient care situations in the future.

PI_NAMEs: TRINKLEY, KATY E (contact)

PROGRAM_OFFICER_NAME: SIDDIQUI, AYESHA SAEED

PROJECT_TERMS: Address;Adoption;Adrenergic beta-Antagonists;antagonist;Architecture;Asthma;Attention;behavioral economics;Blood Pressure;Cardiology;Caring;Categories;Clinic;Clinical;clinical decision support;computerized;contextual factors;Data;design;Development;Effectiveness;Ensure;Evaluation;experience;Fatigue;Future;Glucose;Goals;Guidelines;Health system;Heart failure;heart failure with reduced ejection fraction;high risk;implementation framework;implementation outcomes;implementation science;improved;Informatics;inhibitor;innovation;Institution;Interview;iterative design;Lead;Mentors;Methods;Mineralocorticoid Receptor;Mission;National Heart, Lung, and Blood Institute;operation;Outcome;Patient Care;patient population;Patient-Focused Outcomes;Patients;Pattern;personalized decision;Positioning Attribute;Practical Robust Implementation and Sustainability Model;pragmatic trial;preference;primary care clinic;primary care clinician;programs;prototype;Public Health;Quality of life;Randomized;randomized trial;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Regulation;Research;Research Personnel;Resources;Scientist;Sodium;success;support tools;System;Testing;Time;Training;Translations;Treatment Failure;trial design;usability;valsartan;Work;Workload

PROJECT_TITLE: Personalizing Clinical Decision Support for Heart Failure Treatment to Clinicians' Needs

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(MA)]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Mental Health;Patient Safety;Prevention;Social Determinants of Health

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Project Narrative Health care workers’ negative behavior towards patients (likely a reflection of low job satisfaction, frustration with delivering HIV care and treatment in extremely resource-limited settings, and burnout) is one of the primary reasons people living with HIV abandon treatment in Mozambique. The purpose of this proposal is to test the impact and implementation of a provider resilience intervention and an anti-stigma intervention, individually and in combination, using a randomized controlled trial design at four health facilities. This potentially high-impact intervention offers the opportunity to test a low-cost, provider-focused approach to improving HIV treatment that, if proven effective at increasing adherence and retention in care, could be tested in a fully powered R01 trial in Mozambique.

PI_NAMEs: AUDET, CAROLYN  (contact)

PROGRAM_OFFICER_NAME: STIRRATT, MICHAEL JAMES

PROJECT_TERMS: Address;Adherence;Anger;antiretroviral therapy;Appointment;Area;Attitude;Behavior;behavior change;Behavioral Mechanisms;Belief;blood product;Burn injury;burnout;care delivery;care systems;Caring;Clinical;clinical care;Clinical Trials;Communities;Community Health Aides;condoms;Continuity of Patient Care;cost;Depersonalization;Educational Status;Emotional;Enrollment;exhaustion;expectation;experience;Feeling;Frustration;Funding;Goals;Guidelines;Health;Health care facility;health care service;Health Personnel;Health Services;Health system;health training;Healthcare;HIV;Human immunodeficiency virus test;implementation science;improved;Individual;Infection;Interruption;Intervention;Job Satisfaction;Language;Lead;Location;low socioeconomic status;Medical;medication compliance;Mental Health Associations;Modeling;Mozambique;Nurses;Occupations;Outcome;Patient Compliance;Patient Self-Report;Patient-Focused Outcomes;Patients;personal protective equipment;Personal Satisfaction;Persons;Pharmaceutical Preparations;Physicians;pilot test;Portuguese;preference;Prevalence;programs;promote resilience;Provider;provider intervention;provider-level barriers;Province;psychologic;psychosocial;Published Comment;Quality of Care;Randomized;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Reporting;Research;Research Project Grants;resilience;Resource-limited setting;satisfaction;service delivery;Services;side effect;Site;social culture;social stigma;standard of care;Stigmatization;Testing;therapy design;tool;Traditional Medicine;Training;treatment adherence;Treatment outcome;treatment services;trial design;Trust;uptake;Viral;Woman

PROJECT_TITLE: Estamos Juntos (We are Together): Improving HIV care delivery by capacitating health care providers


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Aging;Arthritis;Chronic Pain;Genetics;Osteoarthritis;Pain Research;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: SAN CARLOS

ORG_NAME: DORIAN THERAPEUTICS, INC.

PHR: Osteoarthritis (OA) is a highly prevalent musculoskeletal disorder affecting 303 million people globally in 2017. Since OA is associated with aging and obesity which are on the rise in global population, its prevalence is also dramatically increasing. Currently there is no treatment that can prevent, stop, or even restrain progression of OA; the current OA pain medications have several side effects that increase the disease burden. We have identified a novel target whose inhibition promotes cellular regeneration while blocking senescence and will develop a small molecule inhibitor to be tested as a disease-modifying treatment in OA.

PI_NAMEs: ADORNO, MADDALENA  (contact)

PROGRAM_OFFICER_NAME: FOX, JENNIFER THERESA

PROJECT_TERMS: Adult;adult stem cell;Affect;age acceleration;Aging;aging related;Analgesics;analog;antagonist;Apoptosis;Bacterial Artificial Chromosomes;Biochemical;Biological Assay;BMI1 gene;bone marrow mesenchymal stem cell;burden of illness;Cartilage;Catabolism;CDKN2A gene;Cell Aging;cell regeneration;Cells;Chondrocytes;Chromatin;Chromatin Remodeling Factor;Chromosome 21;Chronic;Clinical Trials;Collagen;Congenital Disorders;cytotoxicity;Data;Degenerative polyarthritis;Deposition;Development;differential expression;Disease;Dose;Down's Syndrome;Down-Regulation;drug candidate;drug development;Drug Kinetics;Early Onset Alzheimer Disease;efficacy testing;Enzymes;Epigenetic Process;Formulation;functional improvement;Gene Expression;Genes;Genetic;genetic variant;genomic locus;Goals;Health;Histology;Histone H2A;Histones;Human;human tissue;Immune System Diseases;improved;In Vitro;in vivo;Injections;innovation;Intra-Articular Injections;joint destruction;Kinetics;Knee;Knee Osteoarthritis;knee replacement arthroplasty;knock-down;Lead;lead candidate;lead optimization;lead series;Link;Luciferases;Lysine;Maintenance;Measures;Mediating;Mesenchymal Stem Cells;meter;Microarray Analysis;Mitochondria;Modeling;mouse model;Musculoskeletal Diseases;Natural regeneration;novel;Obesity;Operative Surgical Procedures;osteoarthritis pain;Osteoporosis;Pathology;patient biomarkers;patient population;patient stratification;Patients;Peptide Hydrolases;Permeability;Persons;Pharmaceutical Preparations;Pharmacodynamics;pharmacokinetics and pharmacodynamics;Phase;Physiological;Plasma;Population;preclinical efficacy;Prevalence;prevent;Proliferation Marker;promoter;Property;Rattus;Recombinants;Regulation;response;restraint;RNA marker;Role;Safety;scaffold;senescence;Series;side effect;Site;Small Business Innovation Research Grant;Small Interfering RNA;small molecule;small molecule inhibitor;Solubility;Specificity;Stains;stem cell function;stem cell self renewal;Stratification;Synovial Fluid;systemic toxicity;Testing;Therapeutic Index;Time;Tissues;Toxic effect;Toxicity Tests;Toxicology;Treatment Efficacy;treatment response;Ubiquitin;ubiquitin isopeptidase;Variant;vector

PROJECT_TITLE: Small molecule targeting an epigenetic regulator for the treatment of osteoarthritis


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Bioengineering;Eye Disease and Disorders of Vision;Genetics;Neurodegenerative;Neurosciences

PHR: Normal strength and structure of elastic fibers surrounding the optic nerve head has been linked to glaucoma which is the leading cause of irreversible vision loss. We propose to use our unique animal models to test mechanistic association of abnormal elastic fibers with optic nerve damage. We will also test the novel therapeutic strategy for glaucoma treatment by targeting tissue biomechanics.

PI_NAMEs: KUCHTEY, RACHEL W (contact)

PROGRAM_OFFICER_NAME: SONG, HONGMAN

PROJECT_TERMS: Alleles;Animal Model;Aorta;Aortic Aneurysm;Atomic Force Microscopy;Axon;Axonal Transport;Biomechanics;Biometry;Blindness;Clinical;Collagen;Collagen Fiber;Cornea;crosslink;Data;Defect;Development;Disease;effectiveness testing;Elastic Fiber;Elastin;Elderly;Electronics;Elements;Etiology;Exfoliation Syndrome;Exhibits;Extracellular Matrix;Eye;FBN1;Genes;genetic variant;genipin;Glaucoma;Grant;High Prevalence;Histology;Human;Immunohistochemistry;insight;Intervention;Investigation;life span;Link;malformation;Marfan Syndrome;Measures;Microfibrils;Microscopy;Monitor;mouse model;Mus;mutant;Mutant Strains Mice;Mutation;nerve damage;neuroprotection;novel;novel strategies;novel therapeutic intervention;null mutation;Ocular Pathology;Optic Disk;Optic Nerve;Organ;Papillary;Pathogenesis;Pathology;Patients;Pelvic floor structure;Pharmaceutical Preparations;Phenotype;Pia Mater;Play;Population;Predisposition;prevent;Property;Protein-Lysine 6-Oxidase;Ptosis;Publishing;Receptor, Angiotensin, Type 1;retinal ganglion cell degeneration;Retinal Ganglion Cells;Risk;Role;scaffold;Sclera;stem;Structure;success;targeted agent;Testing;Therapeutic Intervention;Thinness;Time;timeline;Tissues;transmission process;Treatment Efficacy

PROJECT_TITLE: Targeting Tissue Biomechanics for Treatment of Glaucoma


ORG_CITY: SYRACUSE

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UPSTATE MEDICAL UNIVERSITY

PHR: PROJECT NARRATIVE Progressive trabecular meshwork stiffening contributes to persistent intraocular pressure elevation in primary open-angle glaucoma. This work seeks to understand how trabecular meshwork cells retain a memory of their past environments, and how this impacts their future behavior. Understanding the mechanisms that control the persistence of trabecular meshwork dysfunction will help find new therapies to treat this blinding disease.

PI_NAMEs: HERBERG, SAMUEL  (contact)

PROJECT_TERMS: Actins;Actomyosin;Adopted;Aqueous Humor;Behavior;Binding;Biological Models;Biomedical Engineering;Biophysics;Cells;Characteristics;Chromatin;chromatin remodeling;Coupling;Cytoskeleton;Data;Disease;Dose;Encapsulated;Environment;enzyme activity;Epigenetic Process;epigenomics;Excision;experimental study;Extracellular Matrix;Failure;Focal Adhesions;Functional disorder;Future;Gene Expression;Genetic;Genetic Transcription;genome-wide;Glaucoma;HDAC1 gene;Health;Histone Acetylation;Histones;Human;Hydrogels;Hyperactivity;In Situ;innovation;Link;Mechanics;mechanotransduction;Memory;memory acquisition;memory retention;Methylation;Modification;Morphology;novel therapeutic intervention;novel therapeutics;Nuclear;Nuclear Matrix;Nuclear Protein;Pathologic;Pathology;permissiveness;pharmacologic;Phenotype;Physical condensation;Physiologic Intraocular Pressure;Physiological;Play;Polymers;Primary Open Angle Glaucoma;Proteins;Recording of previous events;Resistance;Role;Signaling Protein;soft tissue;stressor;Testing;Time;Tissues;Trabecular meshwork structure;Transcription Coactivator;transcription factor;Vision;Work

PROJECT_TITLE: Role of cellular memory in glaucoma.

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]


NIH_SPENDING_CATS: Attention Deficit Hyperactivity Disorder (ADHD);Behavioral and Social Science;Brain Disorders;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Congenital Heart Disease;Congenital Structural Anomalies;Down Syndrome;Heart Disease;Intellectual and Developmental Disabilities (IDD);Mental Health;Orphan Drug;Pediatric;Rare Diseases;Stimulant Use and Misuse

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: PROJECT NARRATIVE Though children with Down syndrome (DS) are at increased risk for having a comorbid diagnosis of Attention- Deficit / Hyperactivity Disorder (ADHD), ADHD is often under-recognized in children with DS due to “diagnostic overshadowing” by the primary intellectual disability. Even when ADHD is diagnosed in children with DS, ADHD is often under-treated due to a lack of data to support the efficacy and safety of stimulant medication in children with DS+ADHD, especially among the 50% of children with DS who have congenital heart defects for whom there could be increased cardiac risk. This study is the first clinical trial of stimulant medication in children with DS+ADHD and will determine the short- and long-term efficacy and safety of these medications in children with DS+ADHD and has the potential to significantly improve the functional status, behavior, and quality of life of children with DS+ADHD.

PI_NAMEs: ESBENSEN, ANNA J. (contact);FROEHLICH, TANYA E.

PROGRAM_OFFICER_NAME: BARDHAN, SUJATA

PROJECT_TERMS: Academic achievement;accurate diagnosis;Address;Age;aged;Area;Attention deficit hyperactivity disorder;Attenuated;Behavior;Behavioral;behavioral impairment;behavioral phenotyping;Cardiac;Catecholamines;Child;Clinical;Clinical Trials;clinically relevant;Cognitive;Cognitive remediation;comorbidity;Conduct Clinical Trials;congenital heart abnormality;Congenital Heart Defects;Consensus;Data;Diagnosis;Diagnostic;diagnostic criteria;Differential Diagnosis;Disease;Dose;Double-Blind Method;Down's Syndrome;Enrollment;evidence based guidelines;executive function;Functional impairment;functional status;Gender;General Population;Genetic Diseases;Genotype;Goals;Guidelines;heart defect;heart function;high risk;Hyperactivity;Impaired cognition;Impairment;improved;improved outcome;Impulsivity;inattention;Incidence;Intellectual functioning disability;Language;Longterm Follow-up;medication safety;Monitor;Motor;neurophysiology;Outcome;Outcome Measure;Pharmaceutical Preparations;Pharmacotherapy;Phase;Pilot Projects;pilot trial;Placebos;Population;Prevalence;Protocols documentation;Provider;Quality of life;Randomized;randomized, clinical trials;Recommendation;Research;response;Risk;Ritalin;Safety;Sample Size;side effect;Stimulant;stimulant use;Symptoms;Treatment Efficacy;treatment strategy;Uncertainty;Underserved Population;Vulnerable Populations

PROJECT_TITLE: Evaluating Assessment and Medication Treatment of ADHD in Children with Down Syndrome

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Biotechnology;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE The links between ocular surface innervation and disease are apparent; however, there is a wide gap in the understanding how ocular surface nerves may affect and may be affected by disease. This proposal is designed to create large “-omic” data sets that morphologically, anatomically, molecularly, and functionally characterize interactions between ocular surface nerves, epithelial cells, and immune cells during ocular surface health and disease

PI_NAMEs: KAPLAN, DANIEL H;SINGH, HARINDER ;ST LEGER, ANTHONY J (contact)

PROGRAM_OFFICER_NAME: ARAJ, HOUMAM H

PROJECT_TERMS: Address;Affect;afferent nerve;Afferent Neurons;Anatomy;Antibodies;aqueous;Architecture;ATAC-seq;Axon;Back;Binding Proteins;Bioinformatics;Cell Communication;cell type;Cells;chemokine;Colon;Communication;conjunctiva;Cornea;Corneal Diseases;cytokine;Data;Data Set;Databases;Deposition;Dermatology;design;Designer Drugs;designer receptors exclusively activated by designer drugs;Development;Disease;disease model;Dry Eye Syndromes;Environment;Epigenetic Process;Epithelial Cells;Epithelium;Esthesia;Eye;Flow Cytometry;Fostering;Future;gain of function;Ganglia;Gastrointestinal tract structure;Gene Expression;Genetic;Goals;Graft Rejection;Grant;Hand;Health;Herpesvirus 1;Homeostasis;Human;Imaging Techniques;Immune;immune checkpoint;Immunohistochemistry;Immunology;in vivo;Infiltration;Interdisciplinary Study;Intestines;Keratitis;Keratopathy;Knowledge;Label;large datasets;Link;Location;loss of function;Machine Learning;Mass Spectrum Analysis;Mediating;member;Membrane;Microbiology;Modeling;Molecular;Morphology;Mus;Nature;Nerve;nerve supply;neural;Neuroglia;Neuroimmune;neuroimmunology;Neurology;Neurons;Neurotransmitters;neurotrophic factor;novel;ocular surface;ocular surface disease;Ophthalmology;Pain;Pathologic;Pathway interactions;Pattern;Play;Population;prevent;Process;programs;Property;protein expression;Proteins;proteomic signature;Proteomics;public database;receptor;Records;recruit;Regulation;Research;response;Role;Sensory;Shotguns;single-cell RNA sequencing;Skin;small molecule;Stimulus;Structure;Structure of superior cervical ganglion;System;Technology;Tissues;transcriptomics;Transgenic Mice;Vascular Endothelial Growth Factors;Viral;web portal;Wheat Germ Agglutinins;Work

PROJECT_TITLE: Assessing how ocular surface nerves, immune cells, and epithelial cells communicate to encourage neuro-immune homeostasis


ORG_CITY: HARLEM

ORG_NAME: FORT BELKNAP INDIAN COMMUNITY

ORG_STATE: MT

PHR: PROJECT NARRATIVE: The Fort Belknap Community (FBC)-Johns Hopkins School of Nursing (JHU) NARCH XI programs will build individual and tribal capacity to address health disparities and promote wellness on the Fort Belknap Reservation through research and training. Aaniiih and Nakoda students, faculty members, tribal health leaders, and nurses will complete training in STEM, public health, and nursing, and engage in the adaptation and evaluation of the JHSON Mental Health Training program. Additionally, they will participate in hands-on community-based research training through the two research studies to: (1) reduce risk and promote healing after a suicide death and to develop a suicide cluster response plan, and (2) adapt the myPlan app to improve safety and health of adolescents.

PI_NAMEs: YAZZIE, KAREN  (contact)

PROGRAM_OFFICER_NAME: RICHARDS, CRYSTAL LYNETTE

PROJECT_TERMS: acceptability and feasibility;Address;Adolescent;adolescent health;Appointment;behavioral health;Collaborations;college;commune;Communities;community based participatory approach;community based participatory research;community based research;Comprehension;Data Collection;Death Rate;design;Development;Discipline of Nursing;disparity elimination;Educational Status;Emergency Situation;Evaluation;experience;Faculty;Feeling suicidal;Future;Goals;Graduate Enrollment;hands on research;healing;Health;Health Disparities Research;health disparity;Health Personnel;Health Priorities;Health Professional;Health Promotion;high risk;high school;High School Student;human centered design;implementation study;improved;Indian reservation;Individual;Intervention;Knowledge;Leadership;Learning;member;Mental Health;Mental Health Services;Native American community;Native American Research Center for Health;Native Americans;Nurses;Pathway interactions;personalized decision;Phase;Positioning Attribute;Prevention;Program Development;programs;promote resilience;protective factors;Public Health;Public Health Education;Qualitative Research;Reduce health disparities;reducing suicide;relationship abuse;Reporting;Research;Research Methodology;Research Personnel;Research Project Grants;research study;Research Training;Reservations;resilience;response;Risk Factors;Risk Reduction;Rural;rural setting;Safety;safety and feasibility;School Nursing;Scientist;Secure;Social Environment;Specialist;Students;success;suicidal behavior;suicidal morbidity;suicidal risk;Suicide;Suicide attempt;Teacher Professional Development;Technology;tool;Training;training opportunity;Training Programs;Tribal Council;tribal health;Tribes;Trust;undergraduate student;Universities;Work;Youth

PROJECT_TITLE: Fort Belknap - JHU NARCH XI

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-Y(55)]


NIH_SPENDING_CATS: American Indian or Alaska Native;Building Research Capacity at Institutions with Limited NIH Funding;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Racial and Ethnic Minority Health Research;Rural Health;Suicide

PI_NAMEs: BROCKIE, TERESA  (contact)

PROJECT_TERMS: Address;Adolescent;Communication;Communities;Data;design;Evaluation;Faculty;Goals;healing;Health;health training;high risk;improved;Information Dissemination;Interdisciplinary Study;Intervention;Mental Health;Mentors;Monitor;Native American Research Center for Health;Native Americans;Nurses;Prevention;Process;Psychiatric Nursing;Reporting;Research;Research Project Grants;Research Training;Reservations;Resource Development;Resources;response;Risk;rural setting;Safety;Strategic Planning;Structure;Students;suicidal morbidity;Suicide;Teacher Professional Development;Technical Expertise;Technology;Training;training opportunity;Training Programs;tribal community;tribal health;tribal leader;Tribes;Universities

PROJECT_TITLE: Fort Belknap - JHU NARCH XI Administrative Core

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-Y]


NIH_SPENDING_CATS: Genetics;Lung;Orphan Drug;Pulmonary Hypertension;Rare Diseases

ORG_CITY: VALHALLA

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: NEW YORK MEDICAL COLLEGE

PHR: Project Narrative Pulmonary hypertension (PH) is a life-threatening and fatal lung disease, and novel therapeutic approaches directly targeting the vascular remodeling process are critical. Our goal is to define the epigenetic mechanisms underlying the regulation of BMPR2 expression in PAH and characterize the physiological consequences of epigenetic modifications in pulmonary vascular cells. Our findings will be of great public health relevance, as this proposal aims to evaluate the therapeutic potential of a new gene therapy approach, which may cure PH.

PI_NAMEs: BISSERIER, MALIK  (contact)

PROGRAM_OFFICER_NAME: SUTLIFF, ROY L

PROJECT_TERMS: Affect;Animal Model;Arteries;Binding;Binding Sites;Blood Vessels;bone loss;bone morphogenetic protein receptors;Bone Morphogenetic Proteins;cell type;Cells;Cessation of life;curative treatments;Data;Disease;Distal;DNA Methylation;DNA receptor;Endothelial Cells;endothelial dysfunction;Endothelium;Enhancers;Epigenetic Process;epigenetic regulation;Failure;Functional disorder;Gene Expression;gene therapy;Genes;Genetic Transcription;Goals;Heart;hemodynamics;histone methylation;Homologous Gene;Human;hypertension control;Hypoxia;Impairment;In Vitro;Induced Mutation;Inhibition of Cell Proliferation;insight;knock-down;Knock-out;Knockout Mice;Life;Lung;Lung Diseases;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Neoplasms;Mediating;Messenger RNA;Methylation;migration;Modeling;Modification;Molecular;Molecular Biology Techniques;MYH11 gene;new therapeutic target;novel;novel therapeutic intervention;Outcome;overexpression;Pathogenesis;Pathway interactions;Patients;Phenotype;Physiological;Play;Pre-Clinical Model;prevent;Process;Prognosis;Proliferating;promoter;public health relevance;pulmonary arterial hypertension;pulmonary arterial pressure;Pulmonary artery structure;Pulmonary Hypertension;pulmonary vascular cells;pulmonary vascular disorder;pulmonary vascular remodeling;Pulmonary Vascular Resistance;Rattus;receptor;Receptor Down-Regulation;receptor downregulation;receptor expression;receptor function;Receptor Gene;Receptor Signaling;Regulation;Reporting;Repression;response;right ventricular failure;RNA;Role;Sampling;Small Interfering RNA;Smooth Muscle Myocytes;Testing;Therapeutic;Therapeutic Effect;therapeutic target;Time;Transcription Alteration;Treatment Efficacy;tumor growth;Vascular Proliferation;Vascular remodeling

PROJECT_TITLE: Role of SIN3a in the epigenetic regulation of the Bone Morphogenetic Protein Receptor Type 2 in pulmonary arterial hypertension


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: GAINESVILLE

ORG_NAME: VETERANS HEALTH ADMINISTRATION

PHR: NARRATIVE Recurrence of Clostridium difficile infection (CDI) causes significant morbidity and mortality and is a major problem in VA healthcare. We cannot currently predict which individuals will develop recurrent CDI. The proposed study will determine bacterial and functional correlates of recurrent CDI, which could be validated and developed as biomarkers to predict C. difficile recurrence.

PI_NAMEs: WANG, GARY P. (contact)

PROJECT_TERMS: acute care;Antibiotic Therapy;Bile Acids;Biodiversity;Biological;Biological Markers;biomarker identification;candidate marker;Cessation of life;Cholesterol;Clinical Research;clinical risk;Clostridium difficile;Complication;Computational Technique;Computing Methodologies;Data;deep sequencing;Development;enteric pathogen;Evolution;fecal transplantation;Future;Genes;Genomics;gut microbiome;gut microbiota;Health Care Costs;Health care facility;Healthcare;Healthcare Systems;healthcare-associated infections;Hospitals;Indigenous;Individual;Infection;innovation;insight;Kinetics;Knowledge;Mass Fragmentography;Measures;Medical;Metabolic;Metabolic Pathway;metabolomics;metagenome;Metagenomics;Methods;Microbe;microbial;microbial community;microbial composition;microbiome;microbiome analysis;microbiome research;microbiota;microbiota metabolites;Monitor;Morbidity - disease rate;mortality;novel;novel strategies;Patients;prevent;Preventive;preventive intervention;Primary Prevention;prospective;Prospective Studies;Recovery;Recurrence;recurrence prevention;recurrent infection;Research;Resistance;Resolution;Ribosomal RNA;Risk;Risk Factors;Role;Sampling;screening;Statistical Methods;Structure;success;Testing;Therapeutic;Uncertainty;Veterans;virtual;Work

PROJECT_TITLE: Defining omic-signatures in recurrent Clostridium difficile infection

STUDY_SECTION: INFB

STUDY_SECTION_NAME: Infectious Diseases B[INFB]


NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Pediatric;Primary Health Care;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

PROJECT_TERMS: Address;American Indians;Behavioral;behavioral health;care outcomes;certificate program;college;Communities;community based research;community planning;cultural competence;Data;Data Collection;data dissemination;Decision Making;design;Development;Discipline of Nursing;Education;Educational Status;Educational workshop;Engineering;Enrollment;Faculty;Foundations;fundamental research;Future;Goals;Graduate Enrollment;Grant;Health;health disparity;Health Priorities;Health Professional;Health system;health training;high school;high school program;High School Student;higher education;improved;Indigenous;indigenous community;innovation;Knowledge;meetings;Mental Health;Mental Health Services;Mentors;Mentorship;Methodology;National Institute of Neurological Disorders and Stroke;Native American community;Native American Research Center for Health;Native American Tribe;Nurse Administrator;Nurses;Nursing Faculty;Pathway interactions;Patients;Persons;Policy Developments;Postbaccalaureate;posters;Program Development;programs;prospective;Psyche structure;Psychiatric Nursing;Public Health;Public Health Education;Public Health Nursing;Reduce health disparities;Research;Research Methodology;Research Project Grants;Research Training;Reservations;Rural;School Nursing;Science;Science, Technology, Engineering and Mathematics;Scientist;skills;Societies;Students;success;summer internship;symposium;therapy design;Training;Training and Education;Training Programs;tribal community;tribal health;Tribes;undergraduate student;United States Indian Health Service;United States National Institutes of Health;Universities;Work;Youth

PROJECT_TITLE: Fort Belknap Student, Faculty/Tribal Health Leader, and Nurse Training


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Immunotherapy;Neurosciences;Rare Diseases

ORG_CITY: SAN FRANCISCO

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Glioblastoma (GBM) is an incurable disease with short median overall survival. Macrophage and microglia mediate resistance to current therapies and are profoundly immunosuppressive. Our studies provide the novel mechanisms elucidating why macrophage and microglia are suppressed and highly possible lead to novel therapeutics targets for GBM treatment.

PI_NAMEs: LU, RONGZE OLIVIA (contact)

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: adaptive immunity;Address;Adult;Agonist;anti-tumor immune response;Antitumor Response;Astrocytes;Attenuated;Biological Process;Biology;Brain;Brain Neoplasms;cancer infiltrating T cells;Catalytic Domain;cell type;Cells;Chemotherapy and/or radiation;Clinical;clinical efficacy;Clinical Trials;clinically relevant;Communication;Complex;Cyclic GMP;Data;Development;Disease;Feedback;Foundations;Genes;Genetic Transcription;Glioblastoma;Glioma;Goals;Holoenzymes;Immune;Immune response;immunoregulation;Immunotherapeutic agent;Immunotherapy;improved;in vivo;Inflammatory;inhibitor;insight;Interferon Type I;knock-down;Knowledge;Lead;Macrophage;Malignant neoplasm of brain;Malignant Neoplasms;Mediating;Microglia;Mission;Modeling;Molecular;Mus;Myeloid Cells;National Institute of Neurological Disorders and Stroke;neoplastic cell;Nervous System;Nervous System Disorder;neural;new therapeutic target;novel;novel therapeutics;Operative Surgical Procedures;Outcome;Pathway interactions;Patients;PD-1 blockade;personalized approach;Phase II Clinical Trials;Phenotype;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphotransferases;Play;Protein Dephosphorylation;Protein Isoforms;Protein phosphatase;Radiation;recruit;Recurrence;Regulation;Resistance;response;Role;Sampling;scaffold;screening;Series;Serine;Signal Pathway;Signal Transduction;small molecule;Specificity;standard of care;STING agonists;Substrate Specificity;synergism;System;T cell infiltration;Testing;Therapeutic;Threonine;Transcription Coactivator;tumor;tumor growth;Tumor Immunity;tumor microenvironment;Tumor-associated macrophages;Tumor-Derived

PROJECT_TITLE: Regulation of Macrophage- and Microglia-mediated STING Signaling in Glioblastoma

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


NIH_SPENDING_CATS: Clinical Research;Comparative Effectiveness Research;Cost Effectiveness Research;Infectious Diseases;Malaria;Prevention;Rare Diseases;Vector-Borne Diseases

ORG_CITY: BALTIMORE

ORG_DEPT: PATHOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: PROJECT NARRATIVE Malaria is the leading parasitic threat to humans and a major infectious cause of morbidity and mortality. While there have been concerted efforts to address vector-borne transmission, blood transfusion remains a neglected mode of transmission and strategies to contend with transfusion-transmitted malaria (TTM) are the exception. We propose to conduct one of the largest studies of TTM to date, to characterize the epidemiology of malaria in blood donors, as well as the risk of infection to transfusion recipients in a malaria-endemic country. We will also evaluate the economic viability and relative performance of different testing modalities to develop evidence-based strategies to contend with TTM in endemic and non-endemic countries alike.

PI_NAMEs: BLOCH, EVAN MARTIN (contact)

PROGRAM_OFFICER_NAME: HILL-PRYOR, CRYSTAL DARLEANE-ROBIN

PROJECT_TERMS: Accounting;Address;Adoption;Africa;Africa South of the Sahara;Age;Antibodies;antigen test;arm;Biological Assay;Blood;Blood donor;Blood donor screening;Blood specimen;Blood Transfusion;Characteristics;Clinical;Clinical assessments;Clinical Data;Clinical Trials;comparative;comparative cost effectiveness;Complex;control trial;cost;Cost Analysis;cost effectiveness;cost per quality-adjusted life year;cost-effectiveness evaluation;Country;Data;Demographic Factors;Department of Defense;Development;Donor Selection;Dryness;Economics;Epidemiology;evidence base;experience;Expert Opinion;Funding;Geography;Human;human subject;Incidence;Individual;Infection;infection risk;Infrastructure;insight;International;Laboratories;Malaria;malaria transmission;Mentored Research Scientist Development Award;Mentors;Microscopy;Modality;Modeling;Molecular;Morbidity - disease rate;mortality;neglect;Nested PCR;novel;Outcome;Parasitemia;pathogen;Patients;Performance;Plasmodium;Policies;Population;Prevalence;prevent;Public Health;Publications;Publishing;Randomized, Controlled Trials;Relaxation;Research;Risk;Risk Factors;Running;Safety;sample archive;sample collection;Sample Size;Sampling;screening;Seasons;Severities;sex;simulation;Technology;Testing;Time;transcription mediated amplification;Transfusion;transmission process;Travel;Uganda;vector-borne;Whole Blood

PROJECT_TITLE: The Malaria Transfusion Risk (MATRix) Study

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(JA)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Disability Research;Mental Health;Neurodegenerative;Neurosciences;Physical Activity;Prevention;Rehabilitation

ORG_CITY: BOSTON

ORG_NAME: HEBREW REHABILITATION CENTER FOR AGED

PHR: PROJECT NARRATIVE: In older adults, mild dementia is associated with impaired function within several brain networks that causes numerous symptoms including loss of memory, the ability to complete complex mental tasks, and the capacity to control one’s walking and thus avoid falling and fall-related injuries. This study seeks to assess the separate and combined potential of two different types of transcranial current stimulation (tCS), which are safe and noninvasive technologies that enable selective modulation of brain network function, to provide multi-symptom relief to older men and women with mild dementia. By using state-of-the-art technology to 1) stimulate more than one brain network at the same, and 2) study the relationship between the electrical fields created by tCS and the therapeutic benefit of this intervention for each individual, this trial is expected result in the development of tCS interventions that have maximal impact on daily life function within this vulnerable population.

PI_NAMEs: MANOR, BRADLEY D.;PASCUAL-LEONE, ALVARO  (contact)

PROGRAM_OFFICER_NAME: MCLINDEN, KRISTINA

PROJECT_TERMS: Activities of Daily Living;Affect;Alzheimer's Disease;Anatomy;angular gyrus;arm;Autobiography;Biological Markers;blind;Brain;brain magnetic resonance imaging;Caregivers;Cause of Death;Cephalic;Clinical;clinical effect;cognitive task;Complex;Data;Dementia;Development;disability;Double-Blind Method;Effectiveness of Interventions;electric field;Electrodes;Ensure;Equilibrium;Etiology;Executive Dysfunction;executive function;fall injury;falls;follow up assessment;Foundations;Frequencies;Future;Gait;Hand functions;Head;Home;Impaired cognition;Impairment;improved;Individual;insight;instrumental activity of daily living;Intervention;intervention effect;Left;Life;Maps;Memory;Memory impairment;Memory Loss;Modeling;motor control;motor deficit;motor disorder;Movement;multi-component intervention;older adult;older men;older women;Outcome Study;Participant;Performance;Peripheral;Phase;Physical activity;Pilot Projects;Population;post intervention;Prefrontal Cortex;Protocols documentation;Psyche structure;Quality of life;Randomized;recruit;reduce symptoms;Research Personnel;Resolution;Specificity;stem;Symptoms;Technology;Testing;Therapeutic;therapy design;Time;transcranial direct current stimulation;Translating;Treatment Efficacy;United States;Vulnerable Populations;Walking

PROJECT_TITLE: Multifocal transcranial current stimulation for cognitive and motor dysfunction in dementia


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Behavioral and Social Science;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Racial and Ethnic Minority Health Research

ORG_CITY: HOUSTON

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: PROJECT NARRATIVE Spanish-English emergent bilinguals (EBs) are large and growing proportion of school-aged children in the United States, and approximately 6-8% are affected by developmental language disorder (DLD). Caregiver- delivered language interventions are a practical and promising approach to preventing and treating DLD in the home language, yet little is known about the specific caregiver behaviors that sustain home language development in EBs with or at-risk for DLD in preschool (age 3-5), a period when overall exposure to English increases. By drawing on naturalistic language observations (video observations and daylong recordings), the proposed research will advance our understanding of language development in EBs at risk for DLD, identify promising targets for future strength-based interventions, and develop new approaches to analyzing daylong recordings in bilingual settings.

PI_NAMEs: SURRAIN, SARAH  (contact)

PROGRAM_OFFICER_NAME: RIVERA-RENTAS, ALBERTO L

PROJECT_TERMS: Address;Affect;Age;Award;Behavior;behavior prediction;bilingualism;Books;Caregivers;Child;Child Language;Code;Communication;comparison control;Control Groups;Data;Data Set;Data Sources;Development;early childhood;Effectiveness;English Language;Environment;experience;Exposure to;Family;Family Relationship;Future;Home;Influentials;innovation;insight;Intervention;intervention effect;Knowledge;Language;Language Development;Language Development Disorders;Language Disorders;learning strategy;Linguistics;Maintenance;Mediating;Mentors;Mothers;novel strategies;Nursery Schools;Outcome;parenting intervention;Parents;Phase;Play;Population;Positioning Attribute;Predisposition;Prevalence;prevent;programs;randomized, clinical trials;Research;research faculty;response;Risk;Sampling;School-Age Population;Schools;service providers;skills;Spanish;Spanish/English;Structure;Testing;Toy;Training;Translating;United States;Variant;Virginia;Work

PROJECT_TITLE: Identifying Caregiver Behaviors that Promote Spanish Development in Preschool-aged Emergent Bilinguals at Risk for Developmental Language Disorder

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Colorectal Cancer;Digestive Diseases;Emerging Infectious Diseases;Infectious Diseases;Microbiome

ORG_CITY: CAMBRIDGE

ORG_NAME: HARVARD UNIVERSITY

PHR: Project Narrative The engineering of living cells as programmable therapeutic system is poised to transform therapeutic paradigms, particularly for cancer where some bacteria selectively colonize solid tumors. A central challenge for developing living microbial therapies is the inaccessibility to study this dynamical system consisting of interacting populations of bacteria and cancer cells. This research proposal leverages 3D multicellular coculture technologies and syn- thetic biology tools to engineer novel bacterial systems that sense and express therapeutics specifically in tumors.

PI_NAMEs: HARIMOTO, TETSUHIRO  (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: 3-Dimensional;Acceleration;Address;Animal Model;Antibiotics;Attenuated;Bacteria;Bacterial Genes;Bacteriophages;Biosensor;cancer cell;Cancer Model;cancer therapy;Cell Death;Cells;Chemoresistance;clinical candidate;clinical translation;Coculture Techniques;Colon;Colorectal;Colorectal Cancer;colorectal cancer progression;colorectal cancer treatment;Colorectal Neoplasms;commensal microbes;Complex;Computer Models;Coupled;CT26;cytotoxic;delivery vehicle;Development;Disease Progression;Dose;dynamic system;effective therapy;Engineered Gene;Engineering;Environment;Feedback;Fusobacterium nucleatum;Genes;Goals;Growth;gut microbes;gut microbiota;Homing;Human body;Hypoxia;Immunologic Surveillance;improved;In Situ;In Vitro;in vivo;Libraries;Malignant Neoplasms;Mammalian Cell;Methods;Microbe;microbial;microbiome research;microbiota;Microscopy;Modeling;Monitor;mouse model;Mus;Necrosis;next generation;novel;novel strategies;Oncogenic;Organism;Oxygen;pathogen;Patients;Peptides;Phase;Plasmids;Population;Postdoctoral Fellow;Prevalence;Production;Proliferating;Rapid screening;Repression;Research;Research Project Grants;Research Proposals;response;Risk;Role;Salmonella typhimurium;sensor;skills;Solid Neoplasm;spatiotemporal;Specificity;spheroids;synthetic biology;System;Technology;Testing;Therapeutic;Therapeutic Agents;therapeutic candidate;therapy outcome;Time;Tissues;tool;Toxic effect;Treatment Efficacy;Tropism;tumor;tumor hypoxia;tumor microbiota;tumor microenvironment;tumor progression;Tumor Promotion;Tumor Tissue;Work

PROJECT_TITLE: Engineering tumor-targeting bacteria to sense and deliver therapeutics


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Biotechnology;Brain Disorders;Drug Abuse (NIDA only);Genetics;HIV/AIDS;Infectious Diseases;Neurodegenerative;Neurosciences;Opioid Misuse and Addiction;Opioids;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Substance Misuse

ORG_CITY: LA JOLLA

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE This project will dissect the dysregulated molecular circuitry in the brains of individuals with opioid use disorder and/or HIV infection. The proposal will identify genes that contribute to opioid use disorder and HIV-associated neurocognitive disorders. These approaches could lead to novel gene therapies to control and perhaps reverse the relentless disease state.

PI_NAMEs: CHENG, CHRISTINE  (contact)

PROGRAM_OFFICER_NAME: SATTERLEE, JOHN S

PROJECT_TERMS: 3-Dimensional;Acquired Immunodeficiency Syndrome;acute infection;addiction;Addictive Behavior;Affect;Amygdaloid structure;antiretroviral therapy;Astrocytes;Brain;brain cell;Brain region;brain tissue;Cell Nucleus;cell type;Cells;Chronic;chronic inflammatory disease;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Computer Analysis;Corpus striatum structure;Data Set;Databases;Development;differential expression;Disease;Drug Addiction;Drug usage;economic impact;epigenetic regulation;Event;Exhibits;Exposure to;Family;Gene Expression;gene regulatory network;gene therapy;Genes;HIV;HIV Infections;HIV-1;HIV-associated neurocognitive disorder;Human;immune activation;Immunohistochemistry;Immunosuppression;In Vitro;in vivo;Incidence;Individual;Induced Neurons;induced pluripotent stem cell;Infection;Inflammation;Inflammatory;Knock-out;Lead;lead candidate;Link;Microglia;Molecular;Morphine;neurocognitive disorder;Neuroglia;Neurologic;Neuronal Injury;Neurons;new technology;novel;Nucleus Accumbens;Opioid;opioid misuse;opioid use disorder;Organoids;Pathogenesis;Pathology;Pathway interactions;Patients;Pattern;Persons;Pharmaceutical Preparations;Phenotype;Population;Prefrontal Cortex;Primary Infection;Public Health;Research;resilience;response;Route;Sampling;seroconversion;single nucleus RNA-sequencing;Slice;Social Impacts;Substance Use Disorder;syndemic;Technology;Testing;three dimensional cell culture;Tissue-Specific Gene Expression;Transcript;transcriptome;transcriptomics;Validation;Variant;Viral Load result;Viral reservoir

PROJECT_TITLE: Single Cell Transciptomics of the Opioid Use Disorder and HIV Syndemic in the Human Brain


ADMINISTERING_IC: LM

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Data Science

ORG_CITY: PORTLAND

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Project Narrative The main goal of the Oregon Health & Science University Biomedical Informatics and Data Science College Undergraduate Summer Internship Program is to provide a rich, full-time experience to students to graduate study and careers in biomedical informatics and data science. The funding from this R25 grant will be used to support summer experiences for students with backgrounds that are underrepresented in biomedical informatics and data science. With assistance and coordination from Portland State University, we will support nine students per summer in an experience that includes knowledge and skills development, participation in a research project, a health data ethics and equity seminar, and scientific and career mentoring.

PI_NAMEs: HERSH, WILLIAM R (contact)

PROJECT_TERMS: Academia;Algorithms;biomedical informatics;Cancer Education Grant Program;career;career development;Collaborations;college;Country;course development;curriculum enhancement;Data;Data Science;Data Set;data standards;Equity;Ethics;experience;Exposure to;Faculty;flipped classroom;Funding;Goals;Government;Grant;Health;health data;Healthcare;Industry;Infrastructure;Internships;Knowledge;Knowledge acquisition;Mentors;Mentorship;Minority Groups;Motivation;Oregon;peer coaching;programs;recruit;Research;Research Project Grants;Resources;responsible research conduct;Science;skill acquisition;skills;Source;Student recruitment;Students;summer internship;symposium;Talents;tool;Training;Training and Infrastructure;Training Programs;undergraduate student;Underrepresented Minority;United States National Institutes of Health;United States National Library of Medicine;Universities;university student

PROJECT_TITLE: Attracting Talented and Diverse Students to Biomedical Informatics and Data Science Careers Through Short-Term Study at OHSU


NIH_SPENDING_CATS: Cachexia;Cancer;Clinical Research

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: Adipose inflammation plays a significant role in the wasting of cancer cachexia but is poorly understood. In this proposal, we will dissect the cellular and molecular contributors to a JAK-dependent Tumor-Cytokine-Adipose Axis that increases lipolysis and subsequent wasting in cancer cachexia. Validating this axis in longitudinal cancer patient samples and optimizing inhibition of this axis will improve cancer cachexia patient quality of life and survival.

PI_NAMEs: INFANTE, RODNEY E (contact);IYENGAR, PUNEETH

PROGRAM_OFFICER_NAME: PERLOFF, MARJORIE

PROJECT_TERMS: Adipocytes;adipokines;Adipose tissue;Advanced Malignant Neoplasm;allotransplant;Atlases;Biological Assay;Biopsy;Blood;Blood Vessels;Body Weight;Body Weight decreased;Cachexia;Cancer Cachexia;Cancer Patient;cancer survival;Cardiac;Cells;cellular targeting;Cessation of life;Clinical;Clinical Research;Clinical Trials;Complex;cytokine;Development;Eating;Event;Family;FDA approved;Fractionation;Genetic Models;ghrelin;Human;Immune;improved;In Vitro;Inflammation;Inflammatory;inhibitor;Institutional Review Boards;Interleukin-6;Knockout Mice;leukemia inhibitory factor receptor;LIF gene;Lipase;Lipids;Lipolysis;Malignant Neoplasms;Metabolic;Modeling;Molecular;Molecular Target;mouse model;Mus;Muscular Atrophy;new therapeutic target;Pathway interactions;Patients;Peripheral;Phenotype;Phosphorylation;Play;Process;programs;Protocols documentation;Quality of life;Recombinants;Regimen;Regulation;Resolution;Role;Sampling;sarcopenia;Signal Pathway;Signal Transduction;single molecule;STAT3 gene;Syndrome;Thinness;TNF gene;transcriptome;Triglycerides;tumor;wasting

PROJECT_TITLE: Identifying the Cellular and Molecular Targets of JAK/STAT-Driven Adipose Wasting to Reverse Cancer Cachexia

STUDY_SECTION: TCB

STUDY_SECTION_NAME: Tumor Cell Biology Study Section[TCB]


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: WINSTON-SALEM

ORG_DEPT: BIOLOGY

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

PHR: Narrative Glioblastoma (GBM) is an incurable primary brain tumor of high heterogeneity. This heterogeneity is one of the major obstacles to GBM treatment. To this end, we identified four molecular targets that are over-expressed collectively in all patients with GBM, but not normal brain. This is a unique development and we generated cytotoxic drug conjugates targeting these receptors simultaneously with an increased access to tumors to produce effective molecular resection with long-lasting anti-tumor response. In addition, we will also inflame these immunologically cold tumors with a targeted conjugate so they can mount more effective immune responses to complement the direct killing action of the cytotoxins. This approach has a great potential of significantly improving the management of the disease.

PI_NAMEs: DEBINSKI, WALDEMAR  (contact)

PROGRAM_OFFICER_NAME: OLKHANUD, PUREVDORJ BALJINNYAM

PROJECT_TERMS: Abnormal Cell;Address;Animals;Antitumor Response;assault;Bacterial Toxins;Binding;Brain;brain parenchyma;Canis familiaris;catalyst;Catheters;cell killing;cell transformation;Clinical Protocols;Complement;Convection;Cyclophosphamide;cytotoxic;Cytotoxic agent;Cytotoxin;design;Development;Disease Management;disease model;Dose;Dose Limiting;drug action;drug candidate;Drug Delivery Systems;drug distribution;Drug Monitoring;Engineering;Environment;EphA2 Receptor;EPHA3 gene;EphB2 Receptor;Ephrins;Excision;exhaustion;first-in-human;Glioblastoma;Glioma;good laboratory practice;Good Manufacturing Process;Grant;Growth;Heterogeneity;Human;human disease;human model;IgG1;IL13RA1 gene;Immune response;Immune system;immunogenic cell death;Immunologics;improved;in situ vaccination;Infiltration;Infusion procedures;Interleukin-13;Interleukin-13 Overexpression;Investigational Drugs;Ligands;Magnetic Resonance Imaging;Medicine;Molecular;Molecular Target;Monitor;mutant;neoplastic cell;neovasculature;novel;overexpression;Patients;Pharmaceutical Preparations;Pharmacologic Substance;Phase I Clinical Trials;Play;pre-clinical;pre-Investigational New Drug meeting;Primary Brain Neoplasms;Progression-Free Survivals;Property;real time monitoring;receptor;Recurrence;Reflux;Research;Resistance;response;Role;Safety;safety and feasibility;scaffold;Site;stem-like cell;System;Testing;Therapeutic;Therapeutic Agents;therapy resistant;Time;Toxic effect;translational model;tumor;tumor heterogeneity;tumor microenvironment;tumor progression;Tumor-associated macrophages;Variant

PROJECT_TITLE: Multi-receptor Targeting of Glioblastoma

STUDY_SECTION: CONC

STUDY_SECTION_NAME: Clinical Oncology Study Section[CONC]


ADMINISTERING_IC: HS

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: CLEMSON

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: CLEMSON UNIVERSITY

ORG_STATE: SC

PHR: PROJECT NARRATIVE Safety concerns for children receiving mental and behavioral health care in the emergency department (ED) include delays in care, lack of appropriate psychiatric consults during visits, self-harm, harm against others or the environment, and involuntary restraint use resulting in patient and staff injury. Given the alarming rise in the utilization of the ED for pediatric mental and behavioral health care, there is a critical need to design the work systems in the ED to support safe and effective care. A highly experienced multi-disciplinary team of clinicians, scientists and engineers, will develop safer work systems in the ED for pediatric mental and behavioral health care using a combination of innovative techniques, to address the threats to patient safety.

PI_NAMEs: DIETRICH, ANN MARIE;JOSEPH, ANJALI  (contact);NARASIMHAN, MEERA

PROGRAM_OFFICER_NAME: RODRICK, DAVID

PROJECT_TITLE: Realizing Improved Patient Care through Human-centered Design for Pediatric mental and behavioral health in the Emergency Department(RIPCHD.PED)

STUDY_SECTION: HSQR

STUDY_SECTION_NAME: Healthcare Patient Safety and Quality Improvement Research[HSQR]


ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE There is an urgent need to develop reliable methods to proactively identify and improve work environments with high risk for physician burnout, and doing so will have broad public health relevance by reducing risk for burnout and its negative effects on quality and safety of care. Addressing physician burnout in primary care carries relevance for AHRQ’s priority populations of women, children, the elderly, and low-income patients, who are particularly dependent on high quality primary care. This project will support AHRQ’s mission of producing evidence to make health care safer and higher quality by developing and validating a prediction model to identify high-risk primary care clinics for physician burnout in order to 1) inform resource allocation to clinics with the highest need, 2) tailor process improvements to reduce risk for burnout and poor quality of care, and 3) lay the groundwork for expanding this model to other high-risk practice settings and provider types.

PI_NAMEs: TAWFIK, DANIEL  (contact)

PROGRAM_OFFICER_NAME: WILLIS, TAMARA

PROJECT_TITLE: Development and Validation of a Prediction Model to Address Physician Burnout

STUDY_SECTION: HCRT

STUDY_SECTION_NAME: Healthcare Research Training [HCRT]


ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: Project Narrative This project will develop a new class of Ubiquitin-independent protein-degrading small molecules that function by recruiting target proteins directly to the proteasome. This approach is quite novel and differs from any existing degrader strategy and will greatly simplify the development of degraders. Critical to this effort will be the discovery of high-quality ligands for the 19S Regulatory Particle of the proteasome, which will be accomplished by a novel DNA-encoded library screening strategy.

PI_NAMEs: KODADEK, THOMAS J. (contact)

PROGRAM_OFFICER_NAME: KYI, CINDY WIN

PROJECT_TITLE: Development of Ubiquitin-Independent Degraders


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric

ORG_CITY: ANN ARBOR

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative Auditory processing abnormalities (e.g. auditory hypersensitivity and reduced auditory spatial attention) are common and prominent features in neurodevelopmental disorders such as autism spectrum disorder (ASD). The long-term goal is to investigate the mechanisms how altered myelination and brain connectivity impair auditory processing in neurodevelopmental disorders. A better understanding of the contributions of the neural mechanisms underlying the auditory processing abnormalities to ASD will help guide better therapeutic strategies for individuals with ASD.

PI_NAMEs: KIM, JUN HEE (contact)

PROGRAM_OFFICER_NAME: CYR, JANET

PROJECT_TERMS: Age;Attention;Attentional deficit;Auditory;Auditory Brainstem Responses;auditory processing;Auditory system;autism spectrum disorder;autistic children;Autopsy;Axon;behavior test;Behavioral;behavioral phenotyping;Bilateral;Brain;Brain Diseases;Brain region;Brain Stem;Cell Lineage;Cell Nucleus;Cells;Communication;conditional knockout;Cre lox recombination system;density;Development;Developmental Delay Disorders;Disease;Electrophysiology (science);Equilibrium;Event;Exhibits;Fiber;Functional disorder;Functional impairment;Gene Expression Profile;Genes;Goals;Hearing problem;Human;Hypersensitivity;Impairment;In Vitro;in vivo;individuals with autism spectrum disorder;Knockout Mice;Link;loss of function mutation;Mediating;Modeling;Molecular;mouse model;Mus;Mutation;Myelin;myelination;Nerve;Nervous System;neural;neural circuit;neurodevelopment;Neurodevelopmental Disorder;Neuroglia;neuroimaging;neuromechanism;neuronal excitability;Neurons;neurotransmission;neurotropic;new therapeutic target;novel;oligodendrocyte lineage;Oligodendroglia;postnatal development;Proliferating;regional difference;Research;Role;Sensory;Signal Transduction;social;sound;Speed;Synapses;synaptic function;Synaptic plasticity;Synaptic Transmission;System;Testing;Therapeutic;Transmission Electron Microscopy;transmission process;voltage;Western Blotting;white matter

PROJECT_TITLE: Role of SCN2A in Myelination and Neural Circuit Development in Autism Spectrum Disorder

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


ORG_CITY: CLEVELAND

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

PHR: PROJECT NARRATIVE Septic shock develops when infection overwhelms the body, causing low blood pressure that requires treatment with life-saving medications called vasopressors. The best way to use vasopressors to treat blood pressure in septic shock is unknown. This project aims to better understand how patients respond to vasopressors and predict which medication is best for individuals, which may improve how patients with septic shock are treated.

PI_NAMEs: BAUER, SETH  (contact)

PROGRAM_OFFICER_NAME: BLATCH, SYDELLA ANNE

PROJECT_TERMS: Achievement;Age;behavior change;Biological;Blood Pressure;care delivery;Caring;Cessation of life;Characteristics;Clinic;Clinical;clinical implementation;Clinical Investigator Award;Clinical Pharmacists;clinical practice;clinical predictive model;clinical translation;comorbidity;Consolidated Framework for Implementation Research;Critical Care;Critical Illness;Data;Data Analytics;Data Science;Data Set;Death Rate;Decision Modeling;Development;Disease;Doctor of Philosophy;dosage;Electronic Health Record;Environment;Epinephrine;Ethnography;Failure;Functional disorder;Goals;Health;Health system;Heterogeneity;Hospitals;Hypotension;implementation framework;implementation science;improved;Individual;individual patient;individualized medicine;Infection;Inflammatory;informatics infrastructure;Infrastructure;innovation;Intensive Care Units;International;Intervention;Interview;K-Series Research Career Programs;Knowledge;Leadership;Left Ventricular Ejection Fraction;Life;Logistic Regressions;Machine Learning;Mediating;Mentorship;Methods;model development;Modeling;Modernization;mortality;Norepinephrine;novel;Outcome;Output;patient response;Patient-Focused Outcomes;Patients;Perception;Pharmaceutical Preparations;Pharmacodynamics;Pharmacology;Positioning Attribute;Prediction of Response to Therapy;predictive modeling;pressure;Race;Recommendation;Recording of previous events;Regimen;Research;Research Project Grants;response;Risk;risk prediction model;Role;Scientist;Sepsis;septic patients;Septic Shock;sex;Shock;sociodemographics;stakeholder perspectives;Supportive care;Surveys;Techniques;Testing;theories;therapy outcome;tool;Training;Translational Research;Translations;treatment effect;Treatment Failure;treatment response;treatment strategy;United States;Vasoconstrictor Agents;Vasopressins;Work

PROJECT_TITLE: Personalized vasopressor therapy in patients with septic shock

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Hypertension;Prevention;Primary Health Care

ORG_CITY: ROCHESTER

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: Narrative This study will identify feasible strategies for implementing and sustaining Team Based Home Blood Pressure Monitoring (TB-HBPM) in primary care using a stepped-wedge cluster randomized trial with RE-AIM outcomes (Reach, Effectiveness, Adoption, Implementation, and Maintenance). We will use realist evaluation to identify transferable knowledge for adapting these strategies to other primary care practices.

PI_NAMEs: FISCELLA, KEVIN ANTHONY (contact)

PROGRAM_OFFICER_NAME: MINTZER, KEITH A

PROJECT_TERMS: Abbreviations;Address;Adopted;Adoption;Advisory Committees;African American population;Ambulatory Blood Pressure Monitoring;Attitude;Cardiovascular Diseases;cardiovascular disorder prevention;Caring;Clinical;Cluster randomized trial;Code;Cost Analysis;Data;Diagnosis;Disparity population;Effectiveness;Elements;Evaluation;Evidence based practice;follow-up;formative assessment;Glossary;Goals;Home Blood Pressure Monitoring;Hybrids;Hypertension;hypertension control;implementation cost;implementation evaluation;implementation process;implementation strategy;improved;Infrastructure;Knowledge;Leadership;Learning;Length;Low income;Maintenance;Manuals;Measures;Medical;meetings;Methods;minority patient;Modeling;modifiable risk;Motivation;Office Visits;Outcome;Patient Education;patient engagement;patient oriented;Patients;Performance;Personal Growth;Phase;Practical Robust Implementation and Sustainability Model;Primary Care;primary care practice;primary outcome;Problem Solving;Procedures;Process;Progress Reports;Publishing;Quality of life;racial disparity;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Readiness;Reading;recruit;Reporting;Research Personnel;Resources;Risk Factors;Role;Science;secondary outcome;Site;skills;Testing;theories;Time;timeline;Training;translatable strategy;transmission process;United States;Work

PROJECT_TITLE: Identifying Successful Strategies for Implementing Team-Based Home Blood Pressure Monitoring in Primary Care


ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

NIH_SPENDING_CATS: Brain Disorders;Drug Abuse (NIDA only);Mental Health;Social Determinants of Health;Substance Misuse

ORG_CITY: SAN DIEGO

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: SAN DIEGO STATE UNIVERSITY

PHR: PROJECT NARRATIVE In an effort to achieve diversity in substance use and addiction science, we propose the Addiction Scientists Strengthened through Education and Training (ASSET) program. This program is designed to improve long- term engagement of a diverse addiction scientist workforce to meet the growing U.S. need for effective prevention and treatment of substance use disorders. The ASSET program (10-weeks plus ongoing mentorship for 12 months) will provide junior investigators (postdoctoral and clinical fellows, and junior faculty) with research knowledge, skills, and mentored career development training that will build their long-term confidence and resilience to become independent researchers and leaders in the field of substance use and addiction science.

PI_NAMEs: PITPITAN, EILEEN VIRTUSIO;ZUNIGA DE NUNCIO, MARIA LUISA (contact)

PROGRAM_OFFICER_NAME: HOLMES, ANGELA L

PROJECT_TERMS: Academia;Acceleration;addiction;Address;Applied Research;Area;Biological;California;career;career development;Caring;Clinical;Clinical Research;Collaborations;Communicable Diseases;Communities;community collaboration;comorbidity;Complex;Coupled;design;Development;disability;disadvantaged background;Disparity population;Doctor of Philosophy;Doctor's Degree;Education;education resources;empowerment;Ethnic Origin;Evidence based treatment;experience;Faculty;faculty mentor;Formulation;Fostering;Funding Opportunities;Future;Goals;Grant;Growth;Hand;Health Disparities Research;Heart;Home;human subject;improved;innovation;Institution;inter-institutional;Interdisciplinary Study;Internships;Intervention;Knowledge;laboratory facility;Leadership;Manuscripts;marginalized community;Mediation;member;Mental disorders;Mentors;Mentorship;Methodology;Minority Groups;minority investigator;minority trainee;National Institute of Drug Abuse;National Institute on Alcohol Abuse and Alcoholism;neighborhood disadvantage;Neurosciences;Peer Review;Population;Positioning Attribute;Postdoctoral Fellow;Prevention;programs;Psyche structure;Psychiatry;Public Health;Pump;Race;Research;research and development;Research Personnel;Research Proposals;resilience;response;responsible research conduct;Science;Scientist;Services;skills;social;Strategic Planning;Substance Addiction;substance use;Substance Use Disorder;substance use treatment;Syndrome;therapy development;Training;Training and Education;Training Programs;translational pipeline;Travel;Underrepresented Minority;Underrepresented Populations;underserved community;Universities;Writing

PROJECT_TITLE: Addiction Scientists Strengthened though Education and Training (ASSET)


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Gene Therapy;Gene Therapy Clinical Trials;Genetics;Immunization;Immunotherapy;Nanotechnology;Pediatric;Pediatric Cancer;Rare Diseases;Vaccine Related

PHR: Narrative This proposal will test the hypothesis that RNA loaded nanoparticles (NPs) (FDA-IND approved) drive immunologic rejection of metastatic osteosarcoma (OSA) through myeloid reprogramming and activation against tumor specific antigens. We will study OSA resistance mechanisms that can be overcome with adaptable RNA- NPs and identify correlates for response and escape in mice/client-owned canines (pet dogs diagnosed with OSA) before human clinical trials.

PI_NAMEs: SAYOUR, ELIAS  (contact)

PROJECT_TERMS: Acute;adaptive immune response;adaptive immunity;Adolescent;Adult;Allium cepa;Animals;Antigens;arm;Biological;Biology;Biopsy;Blood;blood-based biomarker;canine model;Canis familiaris;Cells;Cellular Immunity;Child;Childhood Solid Neoplasm;Chronic;Client;Clinical Trials;cohort;comparative;Data;Dendritic Cells;design;Diagnosis;Disease;Disease-Free Survival;Dose;engineering design;exome;FDA approved;Formulation;Hour;Human;Immune checkpoint inhibitor;Immune system;Immunocompetent;immunogenic;Immunologics;immunoregulation;Immunotherapeutic agent;Immunotherapy;Institution;Interferons;lipid nanoparticle;Long-Term Survivors;Lung;Macrophage;Malignant Neoplasms;Mediating;Messenger RNA;Metastatic Neoplasm to the Lung;Metastatic Osteosarcoma;Modeling;Mus;Mutation;Myelogenous;Myeloid Cells;nanoparticle;new technology;novel;Oncology;Osteosarcoma;Outcome Measure;Pathway interactions;Patients;Penetration;Phase;Population;Production;programmed cell death ligand 1;programs;Recurrence;Research Design;Resistance;resistance mechanism;response;response biomarker;RNA;Safety;Serum;single cell sequencing;siRNA delivery;Small Interfering RNA;T cell response;Testing;Therapeutic Effect;therapy resistant;Toxic effect;tumor;Tumor Antigens;tumor microenvironment;Tumor-Derived;vaccine response;Vaccine Therapy;Vaccines;Viremia;Work

PROJECT_TITLE: Overcoming metastatic spread of osteosarcoma with RNA loaded nanoparticles


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Data Science;Genetics;Health Services;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Pediatric;Primary Health Care;Rare Diseases

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE Electronic health records (EHR) provide a population-scale resource to improve the diagnoses of rare diseases, which go unrecognized by most providers due to lack of familiarity. This proposal aims to leverage cutting-edge biomedical informatics and data science methodology to develop, validate and demonstrate the clinical utility of an EHR-driven SMART-on-FHIR based rare diseases clinical decision support system. Support for diagnosis of rare diseases will enable patients and providers to move efficiently beyond diagnoses to treatments and support for their condition.

PI_NAMEs: LIU, CONG  (contact)

PROGRAM_OFFICER_NAME: CHANG, CHRISTINE Q

PROJECT_TERMS: Address;Affect;Algorithms;analytical method;augmented intelligence;Awareness;biomedical informatics;Caring;Clinic;Clinical;clinical data warehouse;clinical decision support;Clinical Decision Support Systems;clinical phenotype;Clinical Trials;Collaborations;Communities;Computer software;Data;Data Science;design;Detection;Deterioration;Development;Diagnosis;Diagnostic;Dimensions;Disease;Electronic Health Record;electronic health record system;Electronic Medical Records and Genomics Network;Ensure;ethical, legal, and social implication;experience;Familiarity;Family;Fast Healthcare Interoperability Resources;Feedback;Genetic;Genetic Diseases;genetic testing;genomic data;Genomic medicine;Genomics;Genotype;Health;health data;Health system;high dimensionality;Hybrids;improved;Individual;Informatics;Institution;interoperability;Knowledge;knowledgebase;Learning;Manuals;Medical center;Medical Genetics;Methodology;Modeling;Natural Language Processing;Network-based;neural network;neural network architecture;Notification;patient engagement;Patients;pediatric department;Pediatric Hospitals;Pediatrics;Performance;Phenotype;PhenX Toolkit;Philadelphia;Physicians;Policy Maker;Population;Population Heterogeneity;Primary Care;Primary Care Physician;primary care provider;primary care setting;Process;Provider;Public Health;Quality of life;Rare Diseases;Recommendation;Recording of previous events;Registries;Research;Research Personnel;Resources;Risk;Sample Size;Silver;Site;Software Validation;Specialist;Surveys;Testing;Text;tool;Training;Translating;Treatment Cost;United States;Universities;usability;vector

PROJECT_TITLE: RESCUE: Rare Disease Detection and Escalation Support via a Learning Health System