NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Firearms Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Homicide and Legal Interventions;Physical Injury - Accidents and Adverse Effects;Racial and Ethnic Minority Health Research;Social Determinants of Health;Violence Research

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

PHR: PROJECT NARRATIVE ____________________________________________________________________ Community firearm violence (CFV), defined as fatal and non-fatal shootings that result from interpersonal violence, is an increasing threat to public health in the United States that disproportionately impacts people and communities from structurally marginalized racial groups. While emerging research indicates that news media reporting on CFV is causing harm to firearm-injured people and impeding effective public health responses, investigations in this area are extremely limited. To reduce gaps in existing knowledge, we will partner with a community-based organization that supports ethical reporting on CFV to define and measure racial and spatial disparities in harmful reporting on CFV in Philadelphia with the goal of producing evidence to inform journalistic guidelines that minimize harmful reporting on CFV.

PI_NAMEs: BEARD, JESSICA H (contact)

PROGRAM_OFFICER_NAME: JOHNSON, JARRETT AINSWORTH

PROJECT_TERMS: Area;Automobile Driving;black men;Censuses;Characteristics;Cities;Collaborations;Communities;community organizations;Consensus;Crime;Data;Data Set;Dehumanization;Delphi Technique;demographics;Development;Disadvantaged;Disparity;Distress;Elements;Epidemiologist;Ethics;Event;evidence base;experience;Firearms;Frequencies;Future;Goals;Guidelines;Gun injury;gun violence;Health;health disparity;Homicide;Hospitals;Incidence;Instruction;instrument;Interpersonal Violence;Investigation;Journalism;Knowledge;Lead;Location;marginalization;marginalized population;mass shooting;Measures;Minor;multidisciplinary;National Institute on Minority Health and Health Disparities;Neighborhoods;news;novel;Participant;Persons;Philadelphia;Play;Policies;Policy Maker;Population;Poverty;professor;Public Health;Race;racial population;Reporting;Research;response;Role;Safety;Scientific Advances and Accomplishments;Severities;sexual assault;Shapes;social;social determinants;Stereotyping;structural health determinants;Structural Racism;Suicide;Suicide prevention;suicide rate;Surgeon;Television;Testing;Trauma;United States;Violence;violence prevention;Work

PROJECT_TITLE: Examining Racial and Spatial Disparities in Harmful News Media Reporting on Community Firearm Violence

STUDY_SECTION: CIHB

STUDY_SECTION_NAME: Community Influences on Health Behavior Study Section[CIHB]


ADMINISTERING_IC: MD

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF PHARMACY

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: BALTIMORE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PHARMACOLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: NARRATIVE There is an urgent public health need to collect valid and reliable data on structural racism before effective interventions to reduce structural racism can be designed. We propose to create an intersectional, multilevel, and multidimensional Structural Racism Measure that includes economic indicators, has measurement invariance (or equivalence), and is valid for both Blacks and Hispanics/Latinos. The new measure will better capture social disadvantage and the lived experience of people with health disparities and will become an important tool for researchers and others working to eliminate health disparities and discrimination.

PI_NAMEs: VILLALONGA OLIVES, ESTER  (contact)

PROGRAM_OFFICER_NAME: GILLMAN, ARIELLE SAMANTHA

PROJECT_TERMS: Area;Back;Behavioral;Belief;Black Populations;Black race;Businesses;Censuses;cognitive interview;Collaborations;Collection;Community Participation;community partners;Complex;COVID-19 mortality;Data;Data Sources;Death Rate;design;Dimensions;Discrimination;economic indicator;Economics;Education;effective intervention;Ensure;Epidemiologist;Ethnic Population;experience;Goals;Graduate Education;Graduation Rates;Health;health determinants;health disparity;health inequalities;Health Promotion;Healthcare;Hispanic;Hispanic Populations;Housing;indexing;Individual;inequitable distribution;Institution;Latino;Latino Population;Lived experience;marginalized population;Measurement;Measures;Methodology;Methods;minority health;minority health disparity;Modernization;mortality;multi-racial;Nature;novel;Olives - dietary;Outcome;Pattern;performance tests;Persons;Policies;Population;Psychometrics;Public Health;Publishing;Qualifying;Quality of life;Race;Racial Equity;Racial injustice;racial minority population;racial population;Research;Research Personnel;residential segregation;Resources;Respondent;response;Sampling;Scientist;social;social disparities;Societies;sound;Spanish;Spanish/English;Stress;Structural Racism;Surveys;System;Techniques;Testing;theories;tool;Translations;United States National Institutes of Health

PROJECT_TITLE: Assessing intersectional, multilevel and multidimensional structural racism for English- and Spanish-speaking populations in the US

STUDY_SECTION: ASPB

STUDY_SECTION_NAME: Analytics and Statistics for Population Research Panel B Study Section[ASPB]


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cannabinoid Research;Cocaine;Drug Abuse (NIDA only);Endocannabinoid System Research;Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: SAN ANTONIO

ORG_DEPT: PSYCHOLOGY

ORG_NAME: TRINITY UNIVERSITY

ORG_STATE: TX

PHR: PROJECT NARRATIVE Developing evidence has revealed that cocaine reward behavior is attenuated following oxytocin administration in rodents, though the specific mechanisms underlying this effect remains unclear. This research project focuses on oxytocin’s potential mechanism within the male and female rat ventral tegmental area (VTA), a central region of the mammalian reward circuitry. Using a novel combination of transgenic rat and viral-mediated silencing of oxytocin or cannabinoid 1 receptors, this project highlights oxytocin’s impact on dopamine neuronal firing in the VTA through its interactions with the cannabinoid receptors to identify a neural mechanism underlying oxytocin’s effect on cocaine preference behavior.

PI_NAMEs: LEONG, KAH CHUNG  (contact)

PROGRAM_OFFICER_NAME: BERTON, OLIVIER

PROJECT_TERMS: Affect;Attenuated;attenuation;Behavior;Behavioral;cannabinoid receptor;CNR1 gene;Cocaine;cocaine related behaviors;cocaine reward;cocaine seeking;Cocaine-Related Disorders;conditioned place preference;Cues;Data;Dopamine;dopaminergic neuron;Endocannabinoids;Female;Frequencies;gamma-Aminobutyric Acid;Glutamates;insight;knock-down;Knock-in;Locomotion;male;Mediating;neuromechanism;Neurons;Neuropeptides;neurotransmission;novel;Oxytocin;Oxytocin Receptor;Peripheral;Pharmaceutical Preparations;Phase;preference;preservation;presynaptic;Process;Production;Rat Transgene;Rattus;receptor expression;Recombinant adeno-associated virus (rAAV);Research Project Grants;reward circuitry;Rodent;Role;short hairpin RNA delivery;small hairpin RNA;Structure;Synapses;Testing;therapeutic target;Time;tool;Training;Transgenic Organisms;Ventral Tegmental Area;Viral

PROJECT_TITLE: Oxytocin Induces Retrograde Metaplasticity to Attenuate CocainePreference Behavior

STUDY_SECTION: MCNP

STUDY_SECTION_NAME:
Molecular and Cellular Neuropharmacology Study Section
[MCNP]


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Urologic Diseases;Women's Health Research

ORG_CITY: INDIANAPOLIS

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: PROJECT NARRATIVE Clinical research training in Obstetrics and Gynecology (OBGYN) has fallen behind other disciplines; however, the challenging problems in OBGYN and women’s health are vitally important to public health. Led by a diverse group of faculty, this four-day clinical research training course will provide a strong foundation in research methodology and valuable learning and networking opportunities for junior faculty and fellows in OBGYN. Ultimately, the course will create a cadre of junior investigators who will help improve the health of women and pregnant people for years to come.

PI_NAMEs: PEIPERT, JEFFREY FRANK (contact)

PROGRAM_OFFICER_NAME: AHN, HELENA HYESOOK

PROJECT_TERMS: Address;adverse pregnancy outcome;Age;Area;Award;Back;Biometry;Caring;Clinical;Clinical Investigator;Clinical Research;Collaborations;design;Diagnosis;Discipline;Discipline of obstetrics;Disease;Education;Ethics;Faculty;Family;Feedback;Financial Support;Foundations;Funding;Future;Future Generations;Goals;Grant;Gynecology;Health;Health Expenditures;Healthcare;improved;Individual;Inequity;infant morbidity;infant morbidity/mortality;Infertility;innovation;insight;interest;knowledge base;Learning;life span;Low Birth Weight Infant;Malignant Female Reproductive System Neoplasm;Malignant neoplasm of cervix uteri;maternal morbidity;Medical Students;meetings;Mentors;Mentorship;Minority Women;mortality;next generation;Participant;Peer Review;people of color;Persons;Physicians;Poverty;pregnant;Premature Birth;Process;Public Health;Publications;Publishing;recruit;Research;Research Design;Research Methodology;Research Personnel;Research Training;Resources;Schedule;Science;Scientific Advances and Accomplishments;Scientist;Sexually Transmitted Diseases;Social Impacts;success;symposium;Time;Training;unintended pregnancy;Urinary Incontinence;Urogenital Diseases;virtual;Woman;Women's Health;Work;Writing

PROJECT_TITLE: Clinical Research and Academic Success in Obstetrics & Gynecology

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Reproduction, Andrology, and Gynecology Study Section[CHHD-R]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Amyotrophic Lateral Sclerosis (ALS);Biotechnology;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunotherapy;Lung;Machine Learning and Artificial Intelligence;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: The primary purpose of this EAP is to administer novel RAPA-501 autologous T cell therapy to high-risk people with ALS (pwALS), with the goal of established the feasibility and safety of this intervention and obtaining a signal of efficacy in this population of pwALS. This EAP project will also yield a wealth of understanding pertaining to the biologic underpinnings of the neuroinflammatory component to ALS progression and its potential amelioration through RAPA-501 TREG/Th2 cell therapy. This EAP will also incorporate AI-based comparator cohort methods that will permit more accurate estimation of RAPA-501 treatment effect in this EAP and will contribute to global efforts to incorporate exploratory comparator arms into ALS clinical trials that lack placebo arms.

PI_NAMEs: BABU, SUMA ;BERRY, JAMES DALE (contact);PAGANONI, SABRINA

PROGRAM_OFFICER_NAME: LYON, DINA MARIE

PROJECT_TERMS: Academic Medical Centers;Acceleration;Address;Adverse event;Amyotrophic Lateral Sclerosis;amyotrophic lateral sclerosis therapy;Anti-Inflammatory Agents;Antigens;Antiinflammatory Effect;Arizona;arm;Autologous;Berry;Biological;Blood Component Removal;Blood specimen;Cell Therapy;cell type;Cells;Cellular Assay;Cessation of life;Characteristics;chemokine;chemotherapy;Clinic;Clinical;Clinical Trials;cohort;Collaborations;Comparison arm;conditioning;CXCL5 gene;cytokine;Data Science;Databases;design;Disease Progression;Dose;Enrollment;Ensure;Event;experience;Failure;FDA approved;FOXP3 gene;GATA3 gene;General Hospitals;Geographic Locations;Goals;high risk;high risk population;Homing;Hospitals;Hybrids;Idaho;IL16 gene;IL8 gene;immune checkpoint;immune reconstitution;Immune System Diseases;Immunotherapy;improved;in vivo;Inflammasome;Inflammation;Inflammatory;Infusion procedures;Interleukin-10;Interleukin-16;Interleukin-4;Interleukin-6;Intervention;Intravenous infusion procedures;Iowa;Light;LOX gene;Machine Learning;manufacture;Mediating;Methods;Microglia;Morbidity - disease rate;mortality;mouse model;Nerve Degeneration;Neurodegenerative Disorders;neurofilament;neuroinflammation;novel;Oregon;Outcome;Oxidative Stress;oxidized low density lipoprotein;Participant;Patients;Peripheral;Persons;Phase;phase I trial;phase I/IIa trial;Phase II/III Trial;Phenotype;phenylmethylpyrazolone;Placebos;Population;prediction algorithm;Prevention;prognostic;programmed cell death ligand 1;programmed cell death protein 1;Protocols documentation;pulmonary function decline;remote monitoring;Research;Research Personnel;Respiratory Failure;Riluzole;Risk;Safety;safety and feasibility;Sampling;Serum;Signal Transduction;Site;slow potential;stem;Symptoms;T cell regulation;T cell therapy;T-Lymphocyte;targeted agent;Testing;Th2 Cells;Therapeutic;Therapeutic Effect;Thymus Gland;Time;TNF gene;treatment effect;trend;Underserved Population;Up-Regulation;virtual;Vital capacity

PROJECT_TITLE: Intermediate-Size Expanded Access Trial of Autologous Hybrid TREG/Th2 Cell Therapy (RAPA-501) of Amyotrophic Lateral Sclerosis


ADMINISTERING_IC: AA

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Pediatric;Prevention;Substance Misuse;Telehealth;Underage Drinking

ORG_CITY: PROVIDENCE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: Project Narrative Young adult men who have sex with men (MSM) have high rates of heavy alcohol use and account for majority of new HIV cases. Text messaging, a ubiquitous technology, is starting to be used to enhance effects of brief interventions and shows promise as a tool to support and maintain behavior change, but there is room for improvement, and further theory-based rigorous development and empirical testing is needed. The proposed study leverages the empirically supported construal level theory (CL T) to, in the MOSAIC K99 phase, develop and pilot test text messages via a user-centered approach with members of the intended end-user population, and in the R00 phase, test the efficacy of CL T-based text messages in reducing heavy drinking and HIV risk among young adult MSM, at the day level, via a fully powered micro-randomized trial.

PI_NAMEs: GEBRU, NIOUD MULUGETA (contact)

PROGRAM_OFFICER_NAME: ROACH, DEIDRA

PROJECT_TERMS: 3-Dimensional;acceptability and feasibility;Address;Age;Alcohol consumption;alcohol measurement;alcohol risk;Alcohols;Behavior;behavior change;behavior test;Behavior Therapy;Behavioral;Behavioral Mechanisms;Body Weight decreased;brief intervention;career;cigarette smoking;Clinical;comparison control;condoms;Data;Development;drinking;drinking behavior;Effectiveness of Interventions;effectiveness testing;efficacy testing;experience;Future;Goals;Heavy Drinking;heavy drinking young adult;high risk sexual behavior;HIV;HIV risk;improved;Individual;innovation;Intervention;Intervention Studies;Interview;Knowledge;live text;member;men who have sex with men;Modeling;Motivation;novel;Online Systems;Outcome;Participant;Persons;Phase;pilot test;Population;Process;programs;Protocols documentation;Randomized;randomized trial;randomized, clinical trials;reduced alcohol use;Reporting;Research;Risk;risk perception;satisfaction;Series;Sex Behavior;skills;Smoking;Structure;Technology;Testing;Text;Text Messaging;texting support;theories;therapy design;therapy development;Thinking;tool;Training;trial design;Unsafe Sex;usability;Work;young adult

PROJECT_TITLE: Applying Construal Level Theory to Develop and Test an Interactive Text Messaging Adjunct Intervention to Reduce Heavy Drinking and HIV Risk


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cardiovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Nutrition;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Sleep Research;Social Determinants of Health;Women's Health Research

ORG_CITY: SALT LAKE CITY

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Project Narrative Women of color have increased prevalence of short sleep duration and poor sleep quality, which increases risk for cardiometabolic disorders such as diabetes and high blood pressure. The results of this community- engaged project conducted among women from the Black/African American, Hispanic/Latinx, Native Hawaiian/Pacific Islander and African Immigrant/Refugee communities will increase our understanding of women’s time use and how the relationships between time spent for sleep, physical activity and other demands affect risk for cardiometabolic disease. Study findings will result in novel interventions to improve the sleep and health of women of color.

PI_NAMEs: BARON, KELLY GLAZER (contact);LOPEZ, IVETTE AMELIA;SIMONSEN, SARA E

PROJECT_TERMS: Acculturation;Address;Affect;African;African American;Age;aged;American;Behavior;Belief;Black race;black women;Blood Pressure;Body fat;Body mass index;Cardiometabolic Disease;cardiometabolic risk;cardiometabolism;Cardiovascular Diseases;Cities;Collaborations;Color;Communities;community advisory board;community collaboration;community engaged research;community engagement;Community Health Aides;Community Participation;Commuting;Data;Diabetes Mellitus;Diet;Dietary Practices;disorder risk;Disparity;Employment;Environmental Risk Factor;epidemiology study;Equilibrium;ethnic diversity;Evaluation;experience;Face;field study;fitbit;Focus Groups;Glycosylated hemoglobin A;Goals;Health;Health behavior;health disparity;health goals;Hispanic;Hour;Housing;Hypertension;Immigrant;improved;improvement on sleep;innovation;interest;Intervention;intervention mapping;Knowledge;Language;Latina;Latinx;Leisure Activities;Leisures;Link;Measures;meetings;member;Methods;Modeling;Morbidity - disease rate;mortality;multi-ethnic;Native Hawaiian;Native Hawaiian or Other Pacific Islander;Not Hispanic or Latino;novel;Pacific Islander;Participant;Perception;Physical activity;poor sleep;Population;Positioning Attribute;Poverty;Prevalence;Process;promote resilience;Public Health;Qualitative Methods;racial diversity;recruit;Refugees;Reporting;Research;Research Personnel;resilience;resilience factor;Risk;Risk Factors;Sleep;Sleep Disorders;sleep health;sleep quality;Sodium Chloride;Statistical Models;stressor;structural determinants;Structure;Surveys;Techniques;Testing;Time;time use;Translating;Trust;Underserved Population;Universities;Utah;Wellness coaching;Woman;women of color;Women's Health;Women's study;Work

PROJECT_TITLE: Addressing sleep health disparities from within: A community-engaged study to understanding sleep and cardiometabolic disease risk among women of color


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Data Science;Drug Abuse (NIDA only);Mental Health;Neurosciences;Opioid Misuse and Addiction;Opioids;Prevention;Substance Misuse

ORG_CITY: NEW HAVEN

ORG_DEPT: PSYCHIATRY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE This project leverages advances in network-based computational neuroscience to dynamically track brain-based trajectories of remission from opioid-use disorder (OUD) during early methadone treatment. By scanning at bi- weekly intervals over three months, this will provide essential proof-of-concept data to help characterize the temporal dynamics of early OUD treatment and associated unique patterns of functional brain organization at unprecedented temporal resolution. By providing mechanistic insight into early OUD treatment, findings should contribute to the scientific response to the growing opioid epidemic and may be used to inform treatment development.

PI_NAMEs: YIP, SARAH  (contact)

PROGRAM_OFFICER_NAME: MOLLICK, JESSICA ANN

PROJECT_TERMS: Abstinence;addiction;Address;Award;Basic Science;Behavior Therapy;Behavioral;Big Data;Brain;brain based;Buprenorphine;case control;Cessation of life;Clinical;clinical care;clinically relevant;computational neuroscience;Costs and Benefits;criminal behavior;Data;Data Set;Decision Making;design;Development;Disease;Disease remission;Dropout;Engineering;Epidemic;Fingerprint;Foundations;Functional disorder;Goals;Hepatitis C Transmission;HIV/HCV;Human;illicit opioid;improved;Impulsivity;Individual;Individual Differences;innovation;insight;International;Intervention;Link;Machine Learning;Magnetic Resonance Imaging;Matched Group;medication for opioid use disorder;Medicine;Mental disorders;Methadone;methadone treatment;Methodology;mortality;Network-based;neural;Neurobiology;neurofeedback;neuroimaging;neuromechanism;Neuronal Plasticity;Neurosciences;novel;novel strategies;Opioid;opioid epidemic;opioid use;opioid use disorder;Outcome;Overdose;Overdose reduction;overdose risk;patient retention;Patients;Pattern;Persons;Pharmaceutical Preparations;Phase;Phenotype;Pilot Projects;Population;predict clinical outcome;Process;programs;protective factors;Psychiatry;Public Health;Recovery;Relapse;Research;resilience;Resources;response;Risk;Risk Factors;Sample Size;Sampling;Scanning;skills;temporal measurement;Therapeutic;therapy development;Time;Translating;Translations;United States;United States National Academy of Sciences;willingness;Work

PROJECT_TITLE: Longitudinal neural fingerprinting of opioid-use trajectories


NIH_SPENDING_CATS: Behavioral and Social Science;Drug Abuse (NIDA only);Neurosciences;Substance Misuse;Tobacco

ORG_CITY: RESEARCH TRIANGLE PARK

ORG_NAME: RESEARCH TRIANGLE INSTITUTE

ORG_STATE: NC

PHR: Project Narrative The orphan G protein-coupled receptor GPR3 appears to be important in substance abuse and is a unique biological target for tobacco use disorder. We will conduct a virtual high-throughput screen followed by a medicinal chemistry campaign and structure activity analysis to develop potent, selective, drug-like GPR3 agonist probes. Potential probes will be validated in cell-based functional assays followed by testing in animal models of nicotine abuse.

PI_NAMEs: FOWLER, CHRISTIE D;GAY, ELAINE ARRINGTON (contact)

PROGRAM_OFFICER_NAME: ANANTHAN, SUBRAMANIAM

PROJECT_TERMS: Acceleration;Agonist;analog;Animal Model;Arrestins;Attenuated;Behavior;behavior measurement;Behavioral;Behavioral Model;Biological;Biological Assay;brain cell;brain pathway;Brain region;cannabinoid receptor;Cause of Death;cell type;Cells;Central Nervous System;Chemicals;Computer Models;Consumption;Cryoelectron Microscopy;Cyclic AMP;Descriptor;Development;Disease;Docking;Dose;Drug Delivery Systems;drug discovery;Effectiveness;effectiveness evaluation;electronic cigarette use;Family;Family member;Female;Filtration;G-Protein-Coupled Receptors;Goals;GPR12 gene;GPR3 gene;GPR6 gene;Grant;Habenula;Health;high throughput screening;In Vitro;in vivo;in vivo evaluation;Individual;Intake;interpeduncular nucleus;Intravenous;Knockout Mice;Lead;Ligand Binding;Ligands;Link;male;Medial;member;Modeling;molecular dynamics;Motivation;Mus;new therapeutic target;Nicotine;nicotine abuse;nicotine cessation;Nicotine Dependence;nicotine self-administration;nicotine vapor;Nicotinic Agonists;Nicotinic Receptors;novel;novel therapeutic intervention;Opioid Receptor;Orphan;Pathway interactions;Pattern;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacologic;Phosphorylation;Principal Component Analysis;Process;Property;Psychological reinforcement;Rattus;receptor;Receptor Activation;receptor function;recruit;Research;Role;scaffold;Self Administration;sex;Signal Transduction;Site;small molecule;Structure;Structure-Activity Relationship;Substance abuse problem;Substance Use Disorder;success;System;Testing;Therapeutic;therapeutic development;Tobacco Dependence;Tobacco Use Disorder;tool;Validation;validation studies;virtual;virtual screening;Wild Type Mouse;Withdrawal

PROJECT_TITLE: Discovery and development of GPR3 agonists for nicotine cessation


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Genetics;Neurosciences;Pediatric;Social Determinants of Health;Substance Misuse

ORG_CITY: ATLANTA

ORG_DEPT: MISCELLANEOUS

ORG_NAME: GEORGIA STATE UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Understanding factors that underpin resilience to the development of substance use disorders (SUD) is critical. Thus, our prior work used a model of brief early resource scarcity to identify molecular changes that promote resilience to addiction-related behaviors in adult rats. Here we extend this work using new approaches to determine if resilience is also observed in the adolescent period–a key period for SUD vulnerability and brain development–and to delineate cell type-specific molecular signatures linked to resilience in key developmental windows.

PI_NAMEs: BANGASSER, DEBRA A (contact);REINER, BENJAMIN CHARLES;WIMMER, MATHIEU

PROGRAM_OFFICER_NAME: MOORE, HOLLY MARIE

PROJECT_TERMS: addiction;Address;Adolescence;Adolescent;Adult;Adult women;Affect;Animal Model;Beds;Behavior;Behavior assessment;Behavioral;behavioral phenotyping;Brain;Brain region;cell type;Cells;Data;Development;discounting;disorder risk;drug of abuse;Drug usage;early experience;early life adversity;Early-life trauma;endophenotype;Environment;Experimental Designs;Exposure to;Female;Follow-Up Studies;Future;Gene Expression;Genes;Genetic Transcription;glutamatergic signaling;Glutamates;Heterogeneity;Housing;Impulsivity;innovation;insight;Intervention;Life;Life Experience;Link;male;Male Adolescents;mature animal;Medial;Mediating;Modeling;Molecular;Molecular Profiling;Morphine;Motivation;neural;Neurons;Neurosciences;neurotransmission;novel;novel strategies;Nucleus Accumbens;Opioid;Outcome;Pathway Analysis;Pathway interactions;pediatric trauma;Pharmaceutical Preparations;Phenotype;postnatal;pre-clinical;Prefrontal Cortex;presynaptic;Procedures;promote resilience;Protocols documentation;Publishing;pup;Rattus;resilience;Resource-limited setting;Resources;reward circuitry;Risk;Risk Reduction;Self Administration;sex;single nucleus RNA-sequencing;Stress;stress resilience;stressor;Substance Use Disorder;Testing;Time;Tissues;Transcription Alteration;transcriptome;transcriptomics;validation studies;vesicle transport;Work

PROJECT_TITLE: Determining the effect of early resource scarcity on adolescent addiction-related behavior and cell-type specific transcription

STUDY_SECTION: PMDA

STUDY_SECTION_NAME: Pathophysiological Basis of Mental Disorders and Addictions Study Section[PMDA]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Neurosciences;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE Opioid addiction is a highly prevalent and devastating disorder with no effective treatments, resulting in an enormous burden on family and society. This work will investigate a unique subpopulation of striatal neurons that co-express both dopamine D1 and D2 receptors that may play critical roles in the cellular and behavioral actions of opioids. If successful, my studies will establish important new avenues for novel, more effective therapeutic strategies for opioid abuse and addiction.

PI_NAMEs: KOZEL, JENESIS  (contact)

PROGRAM_OFFICER_NAME: NAIR, SUNILA GOPI

PROJECT_TERMS: Address;African American Women;AMPA Receptors;Anatomy;Basal Ganglia;Behavior;Behavioral;Biomedical Research;Brain;Case Study;Cells;Communities;conditioned place preference;Corpus striatum structure;Coupled;Development;Disease;Doctor of Philosophy;Dopamine;Dopamine D1 Receptor;Dopamine D2 Receptor;Dopamine Receptor;dopaminergic neuron;DRD2 gene;effective therapy;Electrophysiology (science);Exhibits;Family;family burden;Genetic;Glutamates;graduate school;GTP-Binding Proteins;Hybrids;In Vitro;in vivo;interest;knock-down;Label;Medial;Mediating;Midbrain structure;Modeling;Morphine;morphine administration;Morphology;Motivation;motor control;mouse genetics;Movement;Mus;Neurons;neurotransmission;next generation;novel;Nucleus Accumbens;Opiate Addiction;Opioid;opioid abuse;opioid epidemic;opioid misuse;opioid mortality;opioid use disorder;Output;overexpression;Pathway interactions;Physiological;Physiology;Play;Population;population based;Property;Psychological reinforcement;Public Health;receptor;Receptor Signaling;Research;Research Personnel;response;Rewards;Role;Saline;segregation;Self Administration;Signal Transduction;Signaling Protein;Societies;socioeconomics;Specificity;Structure;success;Synapses;System;therapeutic target;therapeutically effective;tool;Training;Underrepresented Populations;United States;United States National Institutes of Health;Ventral Striatum;Work

PROJECT_TITLE: Dissecting the functional relevance of unique subpopulations of striatal dopamine receptors in opioid use disorder

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F02A-W(20)]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering

ORG_CITY: TEMPE

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

ORG_STATE: AZ

PHR: The mechanisms by which certain mutations can lead to the same apparent native fold but can cause  differences in function is of fundamental biological relevance, whose understanding could lead to new drug  discoveries. It also speaks to broader issues in molecular self-assembly, protein folding in general, biological  and biology-inspired materials, bioengineering, human health and disease. Our proposed work, at the  interface of biology and mathematical topology, will provide the rigorous framework upon which the relation  between structure and function of biomolecules can be understood and controlled to address these  questions.

PI_NAMEs: PANAGIOTOU, ELENI  (contact)

PROGRAM_OFFICER_NAME: NGUYEN, HAN

PROJECT_TERMS: Address;Amino Acids;Biological;Biology;Biomedical Engineering;Data;design;Disease;drug discovery;Evolution;fighting;future pandemic;Geometry;Grain;Health;Human;innovation;Knowledge;mathematical methods;Mathematics;Measures;Methods;Microscopic;Modeling;Molecular;molecular assembly/self assembly;Molecular Conformation;Mutation;mutation screening;National Institute of General Medical Sciences;novel;novel therapeutics;Physics;Positioning Attribute;Property;Protein Analysis;Protein Dynamics;Protein Engineering;protein folding;protein function;protein structure;Proteins;Research;Research Personnel;Site;Structure;System;Testing;Viral;Work

PROJECT_TITLE: DMS/NIGMS 1: Topological Dynamics Models of Protein Function


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Digestive Diseases;HIV/AIDS;Infectious Diseases;Microbiome;Nutrition;Prevention;Substance Misuse;Substance Misuse Prevention

ORG_CITY: CHICAGO

ORG_DEPT: NEUROSCIENCES

ORG_NAME: RUSH UNIVERSITY MEDICAL CENTER

ORG_STATE: IL

PHR: PROJECT NARRATIVE This study seeks to understand how alcohol misuse can worsen inflammation during HIV infection, hypothesizing that this effect is related to alcohol's ability to cause gut leakiness. We are also testing the hypothesis that anti- inflammatory prebiotics can decrease the severity of gut leakiness and inflammation caused by alcohol misuse during HIV infection. The completion of this proposal may lead to the design of novel strategies to prevent/treat inflammation-associated diseases in people living with HIV and alcohol use disorder.

PI_NAMEs: ABDEL MOHSEN, MOHAMED ;KESHAVARZIAN, ALI  (contact)

PROGRAM_OFFICER_NAME: WANG, JOE

PROJECT_TERMS: Adverse effects;Aftercare;alcohol misuse;alcohol prevention;alcohol use disorder;Alcohols;Anti-Inflammatory Agents;antiretroviral therapy;Bacteria;beneficial microorganism;Biopsy;Blood;Body System;Colon;comorbidity;Data;decrease resilience;design;Development;Disease;Disease Progression;DNA;dysbiosis;Exhibits;Feces;Filtration;Foundations;fructooligosaccharide;Growth;gut inflammation;gut microbiome;gut microbiota;Heavy Drinking;High Prevalence;HIV;HIV anti-retroviral;HIV Infections;HIV Seronegativity;Human;immune activation;improved;Individual;Inflammation;Inflammatory;intestinal barrier;Intestines;Leaky Gut;Link;Liver diseases;Mediating;metabolome;microbial;microbiome;microbiome composition;microbiota;Modeling;mortality;Mus;novel strategies;Organ;Organoids;Oxidative Stress;Patients;Permeability;Persons;Plasma;prebiotics;Prevalence;prevent;promote resilience;Proteins;Publishing;reduced alcohol use;Reporting;resilience;RNA;Severities;Sex Orientation;Sigmoid colon;systemic inflammatory response;Testing;Tight Junctions;Tissues;United States;Urine;Viral;Volatile Fatty Acids;zonulin

PROJECT_TITLE: Gut Microbiota-Mediated Inflammatory Interactions Between Alcohol Use Disorders and HIV Infection

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


NIH_SPENDING_CATS: Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases

PHR: PROJECT NARRATIVE The proposed expanded access would provide 200 people living with ALS with 24 months of access to pridopidine, an investigational product that is being tested in a randomized clinical trial for ALS, the HEALEY ALS Platform Trial. This expanded access would provide broad and long-term safety, biomarker, and real- world efficacy data from a population that is not eligible to enroll in formal clinical trials. By providing a model for evaluating long-term safety, biomarker changes, and clinical efficacy, we are helping to treat participants in this project and also creating a blueprint for the design of scientifically relevant, patient-centric expanded access protocols.

PI_NAMEs: BABU, SUMA ;BERRY, JAMES DALE;PAGANONI, SABRINA  (contact)

PROJECT_TERMS: Affect;Age of Onset;Agonist;ALS patients;Amyotrophic Lateral Sclerosis;Autophagocytosis;Biological;Biological Markers;Brain;Brain Stem;Cell Nucleus;Clinical;Clinical Data;clinical efficacy;Clinical Trials;Data;design;Disability scale;Disease;Disease Progression;Dose;Double-Blind Method;efficacy clinical trial;efficacy study;efficacy trial;Eligibility Determination;Endoplasmic Reticulum;endoplasmic reticulum stress;Enrollment;Ensure;Enteral Feeding;FDA approved;genetic analysis;Genetic Polymorphism;Geography;Goals;healthy volunteer;Human;Huntington Disease;improved;Individual;knock-down;Light;longitudinal dataset;loss of function;Measures;Membrane;Methods;Mitochondria;Modeling;Molecular;Motor;Motor Neurons;mouse model;Mutation;neurofilament;neuroimaging;Neuronal Injury;novel;nucleocytoplasmic transport;open label;Oral;Oral Administration;Oral cavity;Outcome;Outcome Measure;Participant;Pathway interactions;patient oriented;Patient Outcomes Assessments;Patients;Persons;Pharmaceutical Preparations;Pharmacotherapy;Phase;Phenotype;phenylmethylpyrazolone;Physical Function;Placebo Control;Population;primary endpoint;Property;Proteins;Protocols documentation;Psychometrics;Quality Control;Quality of Life Assessment;Randomized;randomized, clinical trials;Randomized, Controlled Trials;receptor;Receptor Activation;receptor function;Receptor Gene;Regimen;remote assessment;Research;research clinical testing;Respiratory physiology;Riluzole;Running;Safety;Serum;sigma-1 receptor;Signal Transduction;Site;small molecule;smartphone application;Speech;standard of care;superoxide dismutase 1;Testing;Therapeutic;therapeutic target;trend;trial design;Vital capacity

PROJECT_TITLE: An Intermediate-Size Expanded Access Protocol for Amyotrophic Lateral Sclerosis with Pridopidine


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Prevention;Primary Health Care;Social Determinants of Health;Telehealth

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: Project Narrative Dentists can play an important role in expanding HIV testing and facilitating access to HIV prevention services for at-risk populations in highly impacted areas. This study will test two complementary interventions, rapid HIV testing in community-health center dental clinics and an interactive text messaging intervention to reduce HIV risk: supporting both the diagnosis and prevention pillars of the Ending the HIV Epidemic initiative. If successful, this model which engages the dental workforce in community health centers in Suffolk County, MA, a designated hotspot, can be replicated at low cost within other high-risk communities.

PI_NAMEs: BECKWITH, CURT G;HENSHAW, MICHELLE M (contact)

PROGRAM_OFFICER_NAME: BACCAGLINI, LORENA

PROJECT_TERMS: Administrator;Adopted;Adoption;Adult;AIDS prevention;Appointment;Area;Behavior;Boston;Caring;Cellular Phone;Cities;Clinic Visits;Cluster randomized trial;cohort;Communities;comparative efficacy;Complementary therapies;cost;County;Data;Dental;Dental Care;Dental Clinics;Dental Offices;Dentists;Development;Diagnosis;effective intervention;efficacy evaluation;Ensure;Epidemic;ethnic minority population;Ethnic Population;experience;Focus Groups;Fostering;geographic disparity;Geography;Goals;Healthcare;high risk;HIV;HIV Infections;HIV risk;Human immunodeficiency virus test;Incidence;Infection;Injecting drug user;Intervention;intervention effect;Interview;live text;Mediator;men who have sex with men;Modeling;Neighborhood Health Center;Newly Diagnosed;Ownership;Patients;Persons;Phase;pilot test;Play;Population;Populations at Risk;pre-exposure prophylaxis;prevent;Prevention;prevention service;Procedures;programs;Provider;Qualitative Research;racial minority population;racial population;randomized, clinical trials;Randomized, Controlled Trials;rapid testing;Research;response;Risk;Risk Behaviors;Risk Reduction;Role;satisfaction;Site;social cognitive theory;socioeconomics;success;System;tailored messaging;Testing;Text Messaging;text messaging intervention;Textiles;therapy design;Time;Training;transmission process;trial comparing;trial design;uptake;Work

PROJECT_TITLE: Testing and Texting in Community Health Center Dental Clinics to Diagnose and Prevent HIV Infection


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Rehabilitation;Social Determinants of Health

ORG_CITY: MEMPHIS

ORG_NAME: UNIVERSITY OF TENNESSEE HEALTH SCI CTR

ORG_STATE: TN

PHR: Exercising regularly is key to cancer survivors experiencing the health benefits of a physically active lifestyle. This project will evaluate novel interventions designed to assist African American cancer survivors in overcoming exercise barriers, developing a physically active mindset, and establishing exercise habits needed to exercise long term. We will generate new scientific knowledge on the factors most important in helping survivors successfully maintain a physically active lifestyle and gain a better understanding of how discrimination influences the outcomes of interventions promoting physical activity maintenance.

PI_NAMEs: MARTIN, MICHELLE Y (contact);ROGERS, LAURA Q

PROJECT_TERMS: Accelerometer;active lifestyle;Address;Adherence;Adopted;Adoption;Affect;African American;African American Women;Attention;Attenuated;attenuation;Behavior;behavior change;Behavior Therapy;Behavioral;biological adaptation to stress;Breast Cancer survivor;cancer health disparity;Cancer Survivor;Cancer Survivorship;Clinical Trials;comorbidity;comparison intervention;Complex;Data;disability;Discrimination;Disparity;disparity elimination;Effectiveness;Emotional;Ethnic Population;Evaluation;Exercise;exercise intervention;exercise program;experience;Experimental Designs;experimental study;Guidelines;Habits;Health;Health behavior;Health behavior change;Health Benefit;health disparity;improved;Individual;insight;Intervention;intervention delivery;intervention effect;Knowledge;Literature;Maintenance;Mediating;Mediator;Medical;Modeling;moderate-to-vigorous physical activity;Monitor;novel;Obesity;obesity risk;Outcome;outcome disparities;Participant;peer coaching;perceived discrimination;Phase;Physical activity;Physical assessment;Physical Function;physical inactivity;Play;poor health outcome;Population;primary outcome;Process;programs;Public Health;Quality of life;racial population;Randomized;Reduce health disparities;Regulation;Relapse;Reporting;Research;Research Design;response;Role;Science;Second Primary Cancers;Self Efficacy;service intervention;social cognitive theory;social health determinants;Source;Stress;success;Survivors;System;Testing;Text Messaging;theories;therapy design;Thinking;Time;treatment as usual;United States;Vulnerable Populations;Work;Writing

PROJECT_TITLE: Making Healthy Habits Stick: Extended Contact Interventions to Promote Long Term Physical Activity in African American Cancer Survivors


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Chronic Pain;Pain Research;Pediatric

ORG_CITY: MADISON

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE This project aims to develop a viable alternative to surgery for children with limb leg discrepancies that require treatment. Developments and insight gained throughout the application are anticipated to benefit similar developments for correcting joint deformities and benign tumor ablation in bones.

PI_NAMEs: BRACE, CHRISTOPHER L (contact);NOONAN, KENNETH J

PROGRAM_OFFICER_NAME: PINTUCCI, GIUSEPPE

PROJECT_TERMS: Abdomen;Ablation;Address;Adoption;Algorithms;Animal Model;Arthritis;articular cartilage;Benign;Biological;bone;Bone Growth;Canis familiaris;Chest;Child;chronic back pain;Clinical;clinical translation;Curettage procedure;Data;Deformity;design;Development;Devices;direct application;Disease;Distal;Dose Rate;Elements;Ensure;Epiphysial cartilage;Equilibrium;Excision;Family suidae;Femur;fibula;follow-up;Fracture;Frequencies;Gait;Geometry;Growth;Heating;Hemorrhage;Human;Incidence;Infection;insight;Intervention;Joints;Lead;Left;Leg;Length;Limb structure;Malignant - descriptor;Mechanics;microwave ablation;microwave electromagnetic radiation;Microwave Tumor Ablation;Morbidity - disease rate;Necrosis;novel;Operative Surgical Procedures;Oryctolagus cuniculus;Pain;Patients;pediatric patients;Positioning Attribute;Post-Procedural Pain;preclinical study;prevent;Procedures;psychologic;Quality of life;Radiofrequency Interstitial Ablation;Recovery;Reproducibility;research clinical testing;Safety;Shapes;side effect;stem;System;Techniques;Technology;Temperature;tibia;Tissues;Translating;Translations;Traumatic injury;treatment optimization;tumor;tumor ablation;tumor eradication;Weight-Bearing state

PROJECT_TITLE: Developing microwave epiphysiodesis to correct limb length discrepancies

STUDY_SECTION: IGIS

STUDY_SECTION_NAME: Imaging Guided Interventions and Surgery Study Section[IGIS]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: LOS ANGELES

ORG_NAME: CHILDREN'S HOSPITAL OF LOS ANGELES

ORG_STATE: CA

PHR: PROJECT NARRATIVE The proposed research will build upon prior community-driven and mixed methods research to evaluate the effectiveness of an online preventative parenting intervention intended to strengthen parent-child relationships among Filipinos, the third largest Asian subgroup in the United States. This research will impact the well-being of Filipino youth as well as society as a whole by expanding the cultural narratives and the evidence base supporting online parenting interventions during middle childhood.

PI_NAMEs: JAVIER, JOYCE RIVERA (contact)

PROGRAM_OFFICER_NAME: LINARES, DEBORAH ELIZABETH

PROJECT_TERMS: 12 year old;Address;Adolescent;Age;age group;Agreement;Anxiety;anxiety symptoms;Asian;Awareness;Behavior;behavioral health;behavioral outcome;California;Child;Child Behavior;child depression;Child Rearing;Childhood;Clinical;Communication;Communities;community organizations;community setting;Conflict (Psychology);depressive symptoms;Development;Discipline;Distress;early childhood;Effectiveness;effectiveness evaluation;effectiveness testing;Enrollment;evidence base;experience;experimental group;externalizing behavior;Face;Family;Family dynamics;Feeling suicidal;Filipino;Funding;Grant;health disparity;Hybrids;Immigrant;Immigrant family;Immigration;implementation facilitators;improved;Individual;intergenerational;Intervention;intervention delivery;Interview;Literature;maltreatment;Mental Depression;Mental disorders;middle childhood;Minority Groups;Modeling;National Center for Advancing Translational Sciences;National Institute of Child Health and Human Development;Not Hispanic or Latino;online intervention;Outcome;Parent-Child Relations;parenting intervention;Parents;Participant;Personal Satisfaction;Pilot Projects;Population Growth;prevent;Prevention program;Preventive;preventive intervention;primary outcome;Process;programs;protective factors;Protocols documentation;Provider;Publishing;Punishment;Qualitative Research;Randomized;Randomized, Controlled Trials;recruit;remote delivery;Reporting;Research;Research Methodology;resilience;Risk;Risk Factors;Sampling;School-Age Population;Scientific Advances and Accomplishments;secondary outcome;Secure;skills;skills training;social cognitive theory;Societies;Stress;Subgroup;substance use;suicidal behavior;theories;therapy design;Training Programs;treatment group;treatment trial;United States;usual care arm;verbal;virtual;Vulnerable Populations;Youth

PROJECT_TITLE: Virtual Positive Parenting Intervention to Promote Filipino Family Wellness: A Randomized Controlled Trial

STUDY_SECTION: HPC

STUDY_SECTION_NAME: Health Promotion in Communities Study Section[HPC]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Cardiovascular;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Depression;Dissemination and Implementation Research;Heart Disease;Mental Health;Mental Illness;Obesity;Pediatric;Physical Activity;Prevention;Social Determinants of Health

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE Reducing the number of youth at high risk for the development of cardiovascular disease requires synergistically addressing both mental and physical health in an appealing, accessible way that has realistic pathways to large scale implementation. We will revise, enhance, and conduct pilot testing on a well-liked afterschool program that uses mentoring to integrate social-emotional learning skills into physical activity programming to enhance its reach and impact at improving physical activity and depression among underserved youth at disproportionate risk for cardiovascular disease development.

PI_NAMEs: HENDEL, KATHERINE R (contact)

PROJECT_TERMS: Academy;Accelerometer;acceptability and feasibility;Address;Adolescent;Adolescent and Young Adult;adolescent mental health;after-school program;Age;American;Area;Cardiovascular Diseases;cardiovascular disorder prevention;cardiovascular disorder risk;career;Cause of Death;child depression;Childhood;Communities;community based evaluation;community intervention;Coupling;Data;Depressed mood;depressive symptoms;design;Development;Diet;Disadvantaged;Disparity population;Dose;efficacy trial;Emergency Situation;Emotional;Environment;experience;Feeling;Feeling hopeless;Focus Groups;Funding;Future;Goals;hands-on learning;Health;Health behavior;high risk;High School Student;implementation research;implementation strategy;improved;Inequity;Insulin Resistance;interest;Intervention;Intervention Studies;K-Series Research Career Programs;Knowledge;Learning Skill;Link;Mental Depression;Mental Health;Mentors;Mentorship;Modeling;multidisciplinary;National Heart, Lung, and Blood Institute;novel;novel strategies;Obesity;Outcome;Participant;Pathway interactions;Pediatrics;Personal Satisfaction;Persons;Phase;Physical activity;physical conditioning;Pilot Projects;pilot test;pilot trial;prevent;Prevention;Prevention program;Prevention strategy;preventive intervention;primary outcome;Process;programs;Qualitative Methods;Quasi-experiment;Questionnaires;Reporting;Research;Research Design;Research Methodology;Research Personnel;Risk;Risk Factors;satisfaction;Schools;sedentary lifestyle;Self Perception;Series;Site;skill acquisition;skills;Sleep;social;social emotional learning;social model;Social support;Structure;Students;Surveys;Testing;Time;Training;university student;Work;young adult;Youth

PROJECT_TITLE: Using a Mentoring AfterSchool Program to Improve Adolescent Mental Health and Physical Activity: A Pilot Study


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

ORG_CITY: ATHENS

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF GEORGIA

PHR: Project Narrative Neurons are heavily depending on mitochondrial trafficking for their survival and functions including synaptic neurotransmission. In this study, we plan to determine whether pathogenic LRRK2 mutations affect mitochondrial trafficking and dynamics in dopaminergic neurons and the underlying mechanisms in pre-clinical mouse models of Parkinson’s disease. These findings will help to develop early therapies for preventing and/or delaying onset of symptoms.

PI_NAMEs: ZHANG, HUI  (contact)

PROGRAM_OFFICER_NAME: SARRAF, SHIREEN AKHAVAN

PROJECT_TERMS: Address;Affect;age group;Age of Onset;age related;ATP Synthesis Pathway;Axon;axonal degeneration;axonopathy;Behavioral;Biochemical;Biological Assay;Brain;Buffers;Calcium;Characteristics;Corpus striatum structure;Data;Defect;Dopamine;dopaminergic neuron;Early treatment;Electron Transport;Electrophysiology (science);Event;experimental study;Failure;Fluorescence;Functional disorder;Genes;Genetic;Haplotypes;Homeostasis;Human;hyperphosphorylated tau;Image;Impairment;In Vitro;in vivo;insight;Isradipine;Kinesin;knock-down;Knock-out;LRRK2 gene;Measures;Mediating;Mitochondria;mitochondrial dysfunction;Morphology;Motor;mouse genetics;mouse model;Mus;mutant;Mutation;neurochemistry;Neurodegenerative Disorders;neuronal survival;Neurons;neuropathology;neurotransmission;neurotransmitter release;optogenetics;overexpression;oxidant stress;Parkinson Disease;patch clamp;Pathogenesis;Pathogenicity;Pathologic;Pathology;Phenotype;pre-clinical;Preparation;prevent;promoter;Proteins;Respiration;Role;Slice;sporadic Parkinson's Disease;Substantia nigra structure;Symptoms;Synapses;tau aggregation;tau expression;tau Proteins;tau-1;Testing;Therapeutic Intervention;trafficking;Transgenic Mice;transmission process;Transportation;two-photon;Virus

PROJECT_TITLE: Synaptic Dysfunction and Energy Failure in Parkinson's Disease

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Brain Disorders;Clinical Research;Dementia;Neurosciences;Physical Injury - Accidents and Adverse Effects;Prevention;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: MOREHOUSE SCHOOL OF MEDICINE

PHR: U01 Narrative: To date, there is a lack of blood-based traumatic brain injury biomarkers that are linked directly to axonal injury and neurodegeneration after TBI. Based on collective literature and our own data, Tau protein and phospho-Tau (P-Tau) can provide following context of use: as prognostic biomarkers for complicated mild TBI patients at risk for persistent post-concussive symptoms lasting more than 3 months. The main objective of this proposal is to conduct analytic validation of Tau and P-Tau (at Thr-231) biomarkers on two advance assay platforms (Quanterix SIOMA, SOFIA-RCA). We obtained new preliminary data showing that both platforms have demonstrated assay sensitivity of measuring Tau and P-Tau in human serum and plasma samples.

PI_NAMEs: MANLEY, GEOFFREY T;WANG, KEVIN KA WANG (contact)

PROGRAM_OFFICER_NAME: TAYLOR-BURDS, CAROL C

PROJECT_TERMS: Acute;Adult;Age;Antibodies;Antigens;Archives;Astrocytes;Axon;axon injury;axonal degeneration;Biological Assay;Biological Markers;biological specimen archives;biomarker validation;Blood;Blood specimen;blood-based biomarker;Brain Concussion;candidate marker;Cephalic;Chronic;Clinical;Clinical Data;Clinical Research;cohort;Control Groups;Data;detection assay;detection platform;detection sensitivity;Development;Diagnosis;Diagnostic;Disease;drug development;Drug Evaluation;Ethnic Origin;FDA approved;Fiber Optics;Florida;Future;Gender;Glasgow Coma Scale;Glial Fibrillary Acidic Protein;Gold;Grouping;Human;Immunosorbents;Injury;Kinetics;Knowledge;Link;Literature;MAPT gene;Measures;member;mild traumatic brain injury;Military Personnel;military veteran;multidisciplinary;Nerve Degeneration;Nervous System Disorder;neurodevelopment;neuronal cell body;Orthopedics;Outcome;Patient-Focused Outcomes;Patients;Performance;Phase;Phosphorylation;Plasma;Post-Concussion Syndrome;pre-clinical research;prognostic;Prognostic Marker;programs;Proteins;Qualifying;Reagent;Recombinants;Reference Values;Research;Risk;Sampling;Serum;Severities;Site;Sports;Standardization;tau Proteins;tau-1;TBI Patients;Testing;tool development;Traumatic Brain Injury;UCHL1 gene;Validation;Vision;Work

PROJECT_TITLE: Analytical Validation of Tau and P-Tau as acute and subacute prognostic biomarkers for complicated mild TBI

STUDY_SECTION: NSD

STUDY_SECTION_NAME: Neurological Sciences and Disorders A Study Section[NSD-A]


NIH_SPENDING_CATS: Amyotrophic Lateral Sclerosis (ALS);Bioengineering;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Machine Learning and Artificial Intelligence;Nanotechnology;Neurodegenerative;Neurosciences;Patient Safety;Rare Diseases

ORG_CITY: NEW YORK

ORG_DEPT: NEUROLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: Project Narrative CNM-Au8 is a concentrated suspension of catalytically active gold nanocrystals that has been shown preclinically to address multiple cellular deficits resulting from compromised energy metabolism associated with amyotrophic lateral sclerosis (ALS), a relentlessly progressive neurodegenerative disease. Exploratory clinical results from two independent Phase 2 clinical trials suggest treatment with an oral 30 mg daily dose of CNM-Au8 is associated with slowed clinical worsening and improved survival, which will be investigated in a Phase 3 clinical trial anticipated to commence in 2023. In this study, Columbia University, Clene, and Synapticure propose an innovative approach to conduct an intermediate-sized ALS Expanded Access Program in 100 people living with ALS from across the United States with the goal of monitoring safety, survival and clinical worsening, as well as evaluating key biomarkers related to disease progression, to generate a body of real-world evidence.

PI_NAMEs: ANDERSON, ERIC ;ANDREWS, JINSY  (contact);GREENBERG, BENJAMIN M

PROJECT_TERMS: Address;Adenosine Triphosphate;Adverse event;Affect;ALS patients;Amyotrophic Lateral Sclerosis;amyotrophic lateral sclerosis therapy;arm;Biological Markers;Blood - brain barrier anatomy;Brain;Calcium;Cells;Cessation of life;Characteristics;Chemicals;Clinic;Clinical;Clinical Research;Clinical Treatment;Clinical Trials;cohort;Collaborations;Country;Creatinine;Data;Data Science;Data Set;Disease;Disease Progression;Dose;Eligibility Determination;Energy Metabolism;Enrollment;Enteral Feeding;Evaluation;Event;experience;Frequencies;Genetic;glutamatergic signaling;Goals;gradient boosting;Health Services;Homeostasis;Impairment;Improve Access;improved;individual patient;Infrastructure;innovation;Investigation;Light;machine learning model;Measures;medical specialties;Metabolism;Methods;Mitochondria;Modeling;Monitor;Motor Neurons;Multicenter Trials;nanocrystal;nanoGold;nanomedicine;Neurodegenerative Disorders;neurofilament;neuron loss;Neurons;neuroprotection;Neuroprotective Agents;Nicotinamide adenine dinucleotide;open label;Oral;Oral Administration;Outcome Measure;Oxidative Stress;Participant;Patients;Persons;Phase;Phase II Clinical Trials;Phase III Clinical Trials;Placebo Control;Plasma;Population;pre-clinical;preclinical study;prediction algorithm;predictive modeling;primary outcome;programs;Property;proteostasis;Protocols documentation;Randomized;Resources;RNA Processing;rural area;rural setting;Safety;safety assessment;Sampling;secondary outcome;Serious Adverse Event;Serum;Specific qualifier value;Spinal Cord;Statistical Models;Surface;survival prediction;Suspensions;telehealth;Time;Tracheostomy procedure;Training;ubiquitin C-terminal hydrolase;United States;Universities;Venous blood sampling;virtual;Visit

PROJECT_TITLE: Intermediate-sized Expanded Access Protocol for CNM-Au8 in Amyotrophic Lateral Sclerosis (ALS).


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_CITY: CAMBRIDGE

ORG_NAME: NATIONAL BUREAU OF ECONOMIC RESEARCH

PHR: OTHER PROJECT INFORMATION – Project Narrative The rising prevalence of Alzheimer’s disease and related dementia (ADRD) with an aging population represents a profound and emergent challenge for our health and long-term care systems. There are also unique aspects and potential barriers to providing healthcare to people with ADRD, who may be less capable of communicating their symptoms and health histories or following through independently on prescribed treatments, and who often rely on family members and other caregivers for support. The proposed research evaluates processes, tools, or policies that may improve decision-making, healthcare access and delivery, and outcomes for people living with ADRD.

PI_NAMEs: BAICKER, KATHERINE  (contact);SIMON, KOSALI ILAYPERUMA

PROGRAM_OFFICER_NAME: NOVAK, PRISCILLA JOY

PROJECT_TERMS: access disparities;Accident and Emergency department;Address;Affect;Aging;aging population;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease related dementia;analytical tool;Area;Automobile Driving;Black Box;care delivery;care outcomes;care systems;Caregiver support;Caregivers;Caring;Clinical;clinical decision-making;Communication;Communities;Complex;Data;Data Sources;Decision Aid;Decision Making;Diagnostic;Disparity;Economics;Educational workshop;Emergency Department patient;Environment;Equity;Family;Family member;Fatigue;Formal caregiver;Funding;Habits;Health;health care availability;health care delivery;health care disparity;health care service;Healthcare;Healthcare Systems;human old age (65+);improved;Incentives;informal caregiver;Infrastructure;innovation;Insurance;Long-Term Care;Machine Learning;machine learning method;Measurement;Medical;Methods;Motivation;novel;Nursing Homes;older adult;Outcome;Patient-Focused Outcomes;Patients;Pattern;payment;Personal Satisfaction;Persons;Phase;Physicians;Play;Policies;Population;pressure;Prevalence;Process;programs;Provider;Race;racial disparity;Recommendation;Recording of previous events;Research;Research Project Grants;Role;Running;Series;Shapes;Symptoms;System;tool;Treatment Effectiveness;treatment pattern;Work

PROJECT_TITLE: Understanding and Improving Healthcare Decision-Making and Outcomes for People Living with Alzheimer's Disease and Related Dementias

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-5 (M5)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurodegenerative;Neurosciences

PHR: OTHER PROJECT INFORMATION – Project Narrative The administrative core transforms a set of independent research projects on understanding and improving healthcare decision-making and outcomes for people living with Alzheimer's disease and related dementias (ADRD) into a vibrant programmatic endeavor. It encompasses not just administrative support, but also intellectual leadership, substantive integration, and interactive opportunities for cross-project collaboration and learning from practitioners and community experts in caring for people with ADRD.

PI_NAMEs: BAICKER, KATHERINE  (contact)

PROJECT_TERMS: Activities of Daily Living;Aging;aging related;alternative treatment;Alzheimer's Disease;Alzheimer's disease related dementia;Attention;Caregivers;caregiving;Caring;Clinical;cognitive ability;Collaborations;Communication;Communities;Community Healthcare;Creativeness;Data Analytics;data archive;data resource;Decision Making;Dementia;Dependence;Deterioration;Development;drug discovery;dynamic system;Economics;Educational workshop;Environment;Evolution;experience;Family;Foundations;functional outcomes;Funding;Glues;Group Meetings;Health;health care delivery;health economics;health inequalities;Health Professional;Health Services Research;Health system;Health Transition;Health trends;Healthcare;human old age (65+);Human Resources;improved;interest;Journals;Judgment;Knowledge;Leadership;Learning;Link;Medical;meetings;middle age;Monitor;Newsletter;Occupational activity of managing finances;Outcome;outreach;Paper;Patient Care;Patients;Pattern;payment;Peer Review;Persons;Play;Policies;Process;Productivity;Program Research Project Grants;programs;recruit;Research;Research Activity;research and development;Research Personnel;Research Priority;Research Project Grants;Research Support;Resource Sharing;Resources;Role;Running;Science;Series;social media;stem;success;symposium;synergism;Talents;Technical Expertise;Thinking;Time;training opportunity;Translating;Work;working group;Writing

PROJECT_TITLE: Administration, Research Coordination, and Planning


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research;Social Determinants of Health

PHR: OTHER PROJECT INFORMATION – Project Narrative The CMS database infrastructure managed by this core is among the richest resource anywhere for research on the healthcare and health of older Americans, including those with Alzheimer’s Disease or related dementias (ADRD). In this continuation, the database will be enriched still further with the addition of Medicare Advantage and Medicaid records; state-of-the-art measures of ADRD symptoms and diagnosis, stages of dementia, and cognitive impairment; state-of-the-art identifiers for patient and to some extent provider race and ethnicity; and potential caregiver identification.

PI_NAMEs: DOYLE, JOSEPH J (contact)

PROJECT_TERMS: Acute;aging related;Agreement;Algorithms;Alzheimer's disease caregiver;Alzheimer's disease related dementia;American;authority;Authorization documentation;beneficiary;Caregivers;Characteristics;Chronic;Clinical;Code;Collection;Computer Security;Data;data archive;data infrastructure;Data Security;Databases;Decision Making;Dementia;Diagnosis;Disabled Persons;dual eligible;Enrollment;ethnic health disparity;Ethnic Origin;Excision;experience;Fee-for-Service Plans;firewall;Funding;Goals;Grant;Health;health care disparity;Healthcare;human old age (65+);human subject protection;Impaired cognition;improved;Individual;Infrastructure;Institutional Review Boards;investigator training;Knowledge;Link;Long-Term Care;Low income;Measurement;Measures;Medicaid;Medicare;Medicare claim;Medicare/Medicaid;Methodology;Methods;Outcome;Patient Care;Patients;Persons;Phase;Procedures;Process;Program Research Project Grants;programs;Provider;Race;racial disparity;Records;Research;Research Personnel;Research Project Grants;Research Support;Resources;Sampling;Spouses;Symptoms;Techniques;Translating;United States Centers for Medicare and Medicaid Services;Update;Work

PROJECT_TITLE: Core B - CMS Data Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Caregiving Research;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research;Social Determinants of Health

PHR: OTHER PROJECT INFORMATION – Project Narrative Alzheimer's disease and related dementias (ADRD) are progressive neurocognitive disorders with an enormous and racially inequitable burden on patients, their families, the healthcare delivery systems, and the entire society. This core will help to address the challenges of ADRD identification and measurement in existing data, and the deficiencies in existing analytic methods across racial and ethnic groups, particularly for identifying beneficiaries with mild cognitive impairment (MCI), the stage at which new medications appear most promising,

PI_NAMEs: SIMON, KOSALI ILAYPERUMA (contact)

PROJECT_TERMS: Address;Admission activity;algorithmic bias;Algorithms;Alzheimer's disease related dementia;analytical method;Area;beneficiary;Black race;care systems;Caregivers;Classification;cohort;Collaborations;Communities;community advisory board;comparative;Data;Data Linkages;Data Reporting;Data Set;Databases;Decision Making;Dementia;dementia care;Development;Diagnosis;Disease Progression;Educational workshop;Electronic Health Record;Ensure;ethnic diversity;ethnic health disparity;Ethnic Origin;Ethnic Population;experience;Family;Feedback;Foundations;Goals;Health;health care delivery;health care settings;Health Services;Healthcare;Hispanic;Home;Hospitalization;Impaired cognition;improved;Individual;informal caregiver;innovation;Institutionalization;Link;Literature;Measurement;Measures;Medicaid;Medical;Medicare;Medicare claim;meetings;Methodology;Methods;mild cognitive impairment;multiple datasets;neurocognitive disorder;Outcome;Patient Self-Report;Patients;Patterns of Care;payment;Persons;Pharmaceutical Preparations;Policies;Population;Program Research Project Grants;programs;Provider;Race;racial disparity;racial diversity;racial health disparity;racial population;Research;Research Activity;Research Personnel;Research Project Grants;Research Support;Role;Science;Series;Severities;Societies;Spouses;Surveys;Symptoms;System;Techniques;Testing;Update;Voice;webinar;Work

PROJECT_TITLE: Core C - Measurement and Methods in ADRD and Racial Disparities Research


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Atherosclerosis;Behavioral and Social Science;Bioengineering;Brain Disorders;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Data Science;Dementia;Emergency Care;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Heart Disease;Heart Disease - Coronary Heart Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Patient Safety

PHR: OTHER PROJECT INFORMATION – Project Narrative An emergency department clinician treating a patient with acute coronary syndrome (ACS) faces difficult decisions about whether to recommend invasive treatment. If the patient is cognitively impaired, assessing health risks and benefits is even more complex. This project will test a machine learning tool called HEARTSPOT that presents a report to help clinicians make this difficult decision. HEARTSPOT will examine each patient’s medical history faster and more completely than any human could and present a summary of its findings to the emergency department clinician in real time.

PROJECT_TERMS: 3-Dimensional;Accident and Emergency department;acute coronary syndrome;acute symptom;Adverse event;Algorithms;Alzheimer's disease patient;Alzheimer's disease related dementia;American;analytical tool;Artificial Intelligence;augmented intelligence;Behavior;Benefits and Risks;Bypass;Cardiac;Cardiac Catheterization Procedures;Caring;Chest Pain;Cholesterol;Clinical;clinical decision-making;Collaborations;comorbidity;Complement component C1;Complex;Computerized Medical Record;Data;Data Set;Decision Aid;Decision Analysis;Decision Making;Dementia;design;Diagnosis;Effectiveness;Elderly;Electronic Health Record;Elements;Emergency Department patient;Emergency Department Physician;Engineering;Environment;Ethnic Origin;Evaluation;Event;Experimental Designs;Face;Goals;Health;health assessment;health care disparity;Health Personnel;Health system;Healthcare;high risk;Hospitals;Human;Hypertension;Impaired cognition;improved;indexing;individual patient;information gathering;innovation;insight;intelligent algorithm;intervention effect;Interview;Learning;Length;Link;Machine Learning;machine learning prediction;Measures;Medical;Medical History;Methods;mortality;Natural Language Processing;Nausea;older patient;Older Population;Operative Surgical Procedures;Outcome;patient population;Patient Preferences;Patient risk;Patient-Focused Outcomes;Patients;Pattern;Persons;Physicians;Population;pressure;programs;Protocols documentation;Provider;provider adoption;provider behavior;Race;Randomized;Randomized, Controlled Trials;Rapid diagnostics;Recommendation;Recording of previous events;Reporting;Research;Resources;Risk;Risk Factors;risk prediction model;risk sharing;rural area;Shortness of Breath;Signal Transduction;Stents;support tools;Symptoms;System;Testing;Time;tool;Training;Trust;unstructured data;urban area;Visit;Work;Writing

PROJECT_TITLE: Project 1 - HEARTSPOT: Evaluating a Machine Learning System to Aid Decision-Making in the Emergency Department for Patients with ADRD


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Dementia;Emergency Care;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurodegenerative;Neurosciences;Palliative Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

PHR: OTHER PROJECT INFORMATION – Project Narrative Provider/patient racial concordance and workforce diversity in medicine is an understudied topic, despite its importance for medical decision making and patient wellbeing. Concordance may impact trust and other social factors that may be particularly important for patients with ADRD because of diminished ability for self- advocacy. Prior evidence suggests that minoritized patients’ trust in medicine may be enhanced when they are paired with a race-concordant provider. This project will investigate the extent of racial concordance between providers and patients, drivers of concordance, and causal impacts of a concordant match on health care use and health.

PROJECT_TERMS: Accident and Emergency department;Admission activity;adverse outcome;Advocacy;Affect;Agreement;Alzheimer's disease patient;Alzheimer's disease related dementia;Ambulatory Care;Analgesics;Area;Association of American Medical Colleges;Automobile Driving;beneficiary;Black race;care outcomes;Caregivers;Caring;Characteristics;Communication;Communities;County;Data;Data Aggregation;Data Sources;Decision Making;dementia care;Demographic Factors;Diabetes Mellitus;Diagnosis;Disparity;Disparity population;Emergency Care;Emergency department visit;Environment;Equity;Ethnic Origin;Ethnic Population;experience;Future;Geographic Locations;Geography;Health;health assessment;health care disparity;Health Care Sector;health care settings;health determinants;health disparity;Health Personnel;Healthcare;Healthcare Systems;Hispanic;hospital readmission;Hospitalization;Human Resources;Hypertension;implicit bias;improved;Indiana;Inpatients;instrument;Measures;Mediating;Medical;medical specialties;Medicare;medication compliance;Medicine;Mental Depression;minority patient;mortality;Newly Diagnosed;novel;Outcome;Pathway interactions;Patient-Focused Outcomes;Patients;Patterns of Care;Personal Satisfaction;Persons;physical conditioning;Physicians;Policies;Population;Primary Care Physician;programs;Provider;Quasi-experiment;Race;racial disparity;racial population;Randomized;Research Design;Role;rural area;safety net;social factors;social stigma;Socioeconomic Factors;Sorting;Specialist;Texas;Time;Trust;urban area;Variant;Work

PROJECT_TITLE: Project 2 - Provider-Patient/Caregiver Racial Concordance and Equity in Health Care Systems: Their Influence on Health and Healthcare Outcomes for Populations with ADRD


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Emergency Care;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Machine Learning and Artificial Intelligence;Neurodegenerative;Neurosciences;Patient Safety

PHR: OTHER PROJECT INFORMATION – Project Narrative This project uses innovative granular data on provider and patient activities in the Emergency Department to study health care outcomes for people living with Alzheimer’s disease and related dementia (ADRD) and the providers who treat them. We assess differences in provider practice patterns for patients living with and without ADRD, tie those differences to provider characteristics, and investigate the impact of provider fatigue and cognitive load on care patterns and health outcomes. This will yield insights into tools to identify and address the underlying drivers of the quality of care delivered to patients with ADRD and thereby improve health and reduce disparities.

PI_NAMEs: KOLSTAD, JONATHAN T. (contact)

PROJECT_TERMS: Accident and Emergency department;Address;Admission activity;Affect;Age;Alzheimer's disease patient;Alzheimer's disease related dementia;Behavior;Belief;Black Box;California;care outcomes;Caregivers;Caring;Characteristics;Clinical;clinical care;clinical decision-making;cognitive capacity;cognitive load;Communication Barriers;comorbidity;Complex;Data;Data Sources;Decision Making;design;Diagnosis;Diagnostic;direct application;Disparity;disparity reduction;Documentation;Economics;electronic health record system;Emergency Department patient;Emergency Department Physician;Environment;Fatigue;Frequencies;Gender;Habits;Health;health care quality;health disparity;Healthcare;improved;improved outcome;Individual;Influentials;innovation;Inpatients;insight;Knowledge;Machine Learning;machine learning method;machine learning model;Measures;Medical;Medicare;Methods;Modeling;novel;Outcome;Patient Care;Patient-Focused Outcomes;Patients;Pattern;Patterns of Care;Persons;Physicians;Play;Population;population health;pressure;Process;Provider;Quality of Care;Race;Randomized;Recording of previous events;Role;San Francisco;Symptoms;synergism;Technology;Testing;Time;tool;Universities;Variant;Work

PROJECT_TITLE: Project 3 - Inside the Black Box of Clinical Decision-Making: Provider Practice Habits, Provider Caseloads, and Implications for Patients with ADRD


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurodegenerative;Neurosciences;Palliative Care;Social Determinants of Health

PHR: OTHER PROJECT INFORMATION – Project Narrative People with Alzheimer’s disease and related dementias (ADRD) face many administrative hassles when interacting with the healthcare system, hassles that are especially difficult for those with dementia to navigate. In this project, we document the exposure of people with ADRD to these hassles and use rigorous quasi- experimental methods to study the causal effects of administrative hassles associated with accessing care and accessing public assistance programs on access to healthcare and health outcomes for people living with ADRD.

PI_NAMEs: LAYTON, TIMOTHY  (contact)

PROJECT_TERMS: access restrictions;Affect;Alzheimer's disease related dementia;American;Appointment;Appointments and Schedules;Attention;beneficiary;Caregivers;Caring;Cognitive;cognitive ability;cognitive task;Communication;comorbidity;Complex;cost;Crowding;Data;Decision Making;Dementia;Dimensions;Disease;Disparity;Eligibility Determination;Enrollment;Environment;Ethnic Origin;experience;Face;Family;family burden;Family Caregiver;Family member;General Population;Genetic Complementation Test;Health;health care availability;health care delivery;health care service utilization;Health Personnel;Health Services Accessibility;Healthcare;Healthcare Systems;improved;Incentives;innovation;Insurance;Insurance Carriers;Learning;Life;Medicaid;Medicare;Medicare/Medicaid;medication compliance;Memory;Mental Health;Outcome;Patients;Personal Satisfaction;Persons;Pharmaceutical Preparations;physical conditioning;Physicians;Policies;pressure;prior authorization;programs;Provider;psychologic;Public Assistance;public health insurance;Quality of Care;Quasi-experiment;Race;Randomized;Reporting;safety net;Self Care;Services;Social support;Social Work;Specialist;Spouses;System;Time;tool;Variant;Work;young adult

PROJECT_TITLE: Project 4 - The Health Impact of Administrative Burdens for People with ADRD


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Neurodegenerative;Neurosciences;Palliative Care;Patient Safety;Social Determinants of Health

PHR: OTHER PROJECT INFORMATION – Project Narrative Nursing homes are key sources of care for millions of older adults, especially those with dementia, but many facilities are unable to consistently deliver high-quality care for these vulnerable patients. To explore the role of payment rates as a tool to address these gaps in quality, this project leverages two recent Medicare nursing home payment reforms as natural experiments. We consider the effects of payment on the quality and safety of care for skilled nursing patients, the mechanisms like staffing that drive these effects, “spillover” effects onto long-stay patients, and the implications of payment changes for disparities in care access and quality. These results will show the benefits and potential unintended consequences of payment reforms and guide future efforts to improve healthcare quality and value for people with dementia and other older adults.

PI_NAMEs: SACARNY, ADAM JON (contact)

PROJECT_TERMS: access disparities;acute care;Address;Affect;Alzheimer's disease patient;Alzheimer's disease related dementia;Automobile Driving;Behavior;care delivery;Care given by nurses;Caring;Characteristics;Clinical;cognitive function;Communicable Diseases;Complement;COVID-19;COVID-19 impact;COVID-19 pandemic;Data;Decision Making;Dementia;design;Discipline of Nursing;Disease Outbreaks;Disparity;Ethnic Origin;Face;Fee-for-Service Plans;flexibility;Future;Health;health care delivery;health care disparity;Health care facility;health care quality;health determinants;Health Personnel;Health Services Accessibility;Healthcare;Home;hospice environment;hospital readmission;Hospitalization;Hospitals;Improve Access;improved;Incentives;instrument;Investments;Literature;Long-Term Care;Measures;Medicaid;Medicare;Mental Depression;Methods;Modeling;Natural experiment;nursing care quality;Nursing Homes;nursing skill;Nursing Staff;older adult;Outcome;patient oriented;patient safety;Patient-Focused Outcomes;Patients;payment;Persons;Policies;Policy Maker;Policy Making;Privatization;Process;programs;Provider;Quality of Care;Quality of life;Quasi-experiment;Race;racial disparity;rate of change;Readiness;Research;resilience;Resources;Risk;Role;Safety;seasonal influenza;Shapes;Shock;simulation;Skilled Nursing Facilities;sociodemographics;socioeconomic disparity;Source;Subgroup;System;Testing;Time;tool;Update;Work

PROJECT_TITLE: Project 5 - Effects of Nursing Home Payment on Patient-Centered Outcomes for Older Adults and People with ADRD


ED_INST_TYPE: SCHOOLS OF NUTRITION

FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: LINCOLN

ORG_DEPT: NUTRITION

ORG_NAME: UNIVERSITY OF NEBRASKA LINCOLN

ORG_STATE: NE

PHR: PROJECT NARRATIVE Obesity and its co-morbidities are major threats to the health of Americans: 42% and 9% of Americans are obese and severely obese, respectively. The Nebraska Center for the Prevention of Obesity Diseases through Dietary Molecules (NPOD) occupies a unique niche in the portfolio of obesity research centers, which is to harness the powers of bioactive food compounds to prevent, treat, and cure obesity and its co-morbidities, thereby leading to economical and consumer-friendly interventions. NPOD researchers have amassed nearly $200 million in research funding and leveraged these funds to document the feasibility of disease prevention through bioactive food compounds in 1044 publications and 758 presentations, as well as intervention studies in rural Hispanic populations in Nebraska and Native Americans in South Dakota.

PI_NAMEs: ZEMPLENI, JANOS  (contact)

PROGRAM_OFFICER_NAME: FRINCU, CRINA

PROJECT_TERMS: Adult;Age;American;Applications Grants;Appointment;Asian;Atherosclerosis;base;Biochemical Pathway;Black race;Cardiovascular Diseases;Centers of Research Excellence;Clinical;comorbidity;cost;Diabetes Mellitus;Diet;dietary;Disease;disorder prevention;Electronic Health Record;Epigenetic Process;ethnic minority;Ethnic Origin;expectation;Faculty;Faculty Recruitment;fatty liver disease;Food;Foundations;Friends;Funding;Future;Grant;Growth;Health;Healthcare Systems;Hispanic;Hispanic Populations;Home;Industry;Inflammation;Institution;Intervention;Intervention Studies;Investments;Iowa;Kansas;Lead;Leadership;Link;Liver diseases;Medical Care Costs;Medical center;member;mid-career faculty;Midwestern United States;Mission;Morbid Obesity;National Institute of Diabetes and Digestive and Kidney Diseases;National Institute of General Medical Sciences;Native Americans;Nebraska;Not Hispanic or Latino;Nutrient;nutrition;Obesity;obesity in children;obesity prevention;Phase;Physical activity;Pilot Projects;Prevalence;prevent;Program Research Project Grants;programs;Publications;Race;Research;Research Infrastructure;Research Personnel;Research Project Grants;rural Hispanic;Sampling;Secure;Services;South Dakota;square foot;success;Taste Perception;tool;United States;United States National Institutes of Health;Universities;Vision;Work

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 RCB-X (C3)]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Nutrition;Obesity;Prevention

PROJECT_TERMS: Advisory Committees;American;Applications Grants;Appointment;base;Biomedical Research;Centers of Research Excellence;Clinical;cohort;Collaborations;Committee Members;comorbidity;cost;Decision Making;dietary;Discipline;Disease;Electronic Health Record;Endowment;Ensure;Expenditure;extracellular vesicles;Faculty;Fee-for-Service Plans;Food;Fostering;Foundations;Funding;Future;Gifts;Grant;Growth;Health;Home;improved;Industry;Infrastructure;Institution;Investments;Leadership;leadership development;Life Style;Liver diseases;Marketing;Mediation;Medical center;member;Mentors;Metabolic Diseases;mid-career faculty;Minor;Mission;Molecular Biology;multidisciplinary;National Institute of General Medical Sciences;Nebraska;Obesity;obesity prevention;operation;Phase;Pilot Projects;Positioning Attribute;prevent;programs;Research;research and development;Research Personnel;Research Project Grants;Role;Sampling;Science;Secure;Services;skills;Source;square foot;success;Talents;Time;Training;United States National Institutes of Health;Universities

PROJECT_TITLE: Administrative Core


PI_NAMEs: HAO, JINGJIE  (contact)

PROJECT_TERMS: Administrative Supplement;Animal Experimentation;Animals;Award;base;Benchmarking;Biomedical Research;Biometry;Businesses;Cellular biology;Centers of Research Excellence;cloud platform;comorbidity;computer center;computerized data processing;Consult;Consultations;cost;Data;data acquisition;design;dietary;Disease;Doctor of Philosophy;Employment;Equipment;equipment acquisition;Expenditure;Experimental Designs;Fee-for-Service Plans;Fees;Fees and Charges;Food;Funding;Goals;Growth;Human Resources;Image;Individual;Industry;Institution;instrument;instrumentation;International;Investments;Laboratories;Laboratory Research;large datasets;Leadership;Mediation;Medical center;meetings;microbiome;Molecular Biology;National Institute of General Medical Sciences;Nebraska;Notification;nutrition;Obesity;obesity prevention;operation;Phase;Phenotype;Positioning Attribute;prevent;Principal Investigator;programs;Qualifying;Randomized;Recording of previous events;recruit;Research;research facility;Resources;Sampling;satisfaction;Secure;service utilization;Services;skills;Speed;square foot;Statistical Data Interpretation;Supercomputing;Surveys;Time;Training;Universities;Wages;Work

PROJECT_TITLE: Biomedical and Obesity Research Core


NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: PROJECT NARRATIVE Healthy beverage consumption in early childhood could significantly decrease life-long chronic disease risk, especially among indigenous children. Identifying effective strength-based interventions that are culturally tailored for indigenous communities could advance health equity by promoting healthy habits throughout childhood with positive benefits across the life span.

PI_NAMEs: GEORGE, CARMEN ;SHIN, SONYA S (contact)

PROGRAM_OFFICER_NAME: FERNANDEZ, ANGELA R

PROJECT_TERMS: 6 year old;Address;Adult;Advocate;aged;Back;Behavior;Beverages;Body mass index;Cardiometabolic Disease;cardiovascular risk factor;Caregivers;Child;Childhood;Chronic;Chronic Disease;Cluster randomized trial;cohesion;Colonialism;Communities;community based participatory approach;community engagement;community involvement;community research;Comparative Effectiveness Research;Consent;Consumption;Control Groups;culturally appropriate intervention;Data;Dental caries;design;Diabetes Mellitus;Diet;Diné Nation;disorder risk;Disparity;drinking water;early childhood;Education;Educational Curriculum;Educational process of instructing;effective intervention;Effectiveness;effectiveness study;Elderly;Enrollment;Ensure;Environment;Equity;experience;Family;Family dynamics;Family health status;Family member;family structure;Future;Goals;group intervention;Habits;Health;health disparity;health equity;health equity promotion;health literacy;Health Personnel;Home;Hypertension;Indigenous;indigenous community;Individual;innovation;interest;intergenerational;Intervention;Leadership;life span;Link;Media Campaign;member;Mentorship;Methods;Modeling;multidisciplinary;Native-Born;Navajo;Nutrition Policy;obesity risk;Outcome;Parents;Pattern;Personal Satisfaction;Population;Prediabetes syndrome;primary caregiver;programs;prospective;protective factors;Randomized;Research;Reservations;Risk;Risk Factors;Rural;Shapes;Site;social media;Spirituality;sugar;sweetened beverage;System;therapy design;tribal college;tribal community;university student;Waiting Lists;Water;water quality

PROJECT_TITLE: Multi-level intervention to promote healthy beverage choices among Navajo families


ED_INST_TYPE: OTHER SPECIALIZED SCHOOLS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Pediatric;Prevention;Primary Health Care;Rural Health;Social Determinants of Health

ORG_CITY: ITHACA

ORG_NAME: CORNELL UNIVERSITY

PHR: Project Narrative Access to health care is a problem for rural youth in underserved communities. The proposed multi-institutional research project will explore the impact of School Based Health Centers on healthcare utilization and outcomes, and evaluate cross-agency collaboration to address social determinants of health. The project will take a multilevel approach to build individual, institutional, community and policy partnerships to address health disparities of underserved rural youth.

PI_NAMEs: BRUNNER, WENDY ;TENNYSON, SHARON  (contact)

PROGRAM_OFFICER_NAME: SOLIS SANABRIA, CAROLINA VANESSA

PROJECT_TERMS: Acute;acute care;Address;age group;analytical method;Area;Asthma;built environment;Caring;Child;Child Health;Chronic;Collaborations;Communities;community based participatory research;community collaboration;Community Health;Community Healthcare;Community Networks;community partners;Community Services;Comprehensive Health Care;Consolidated Framework for Implementation Research;Continuity of Patient Care;County;Data;Data Set;Dental;Economics;Effectiveness;Emergency Situation;Enrollment;Epidemiologist;Evaluation;Evidence based intervention;Face;Family;Family health status;family structure;Focus Groups;Frequencies;Health;health care availability;Health care facility;health care service utilization;Health Care Visit;health disparity;health equity;Health Personnel;Health Policy;Health Services;Health Services Accessibility;Healthcare;Human;improved;Individual;individual patient;innovation;Institution;Interdisciplinary Study;Interview;Local Government;Location;Low income;Measures;medically underserved;Mental Health;Mental Health Services;Methods;migration;morphogens;multidisciplinary;New York;Outcome;Outcome Measure;Patient Selection;Patients;pediatric patients;pediatrician;Performance;Personal Satisfaction;Play;Policies;Poverty;Preventive care;Preventive dental care;Primary Care Physician;Psyche structure;Public Health;Qualitative Research;Quasi-experiment;Records;Research;Research Design;Research Personnel;Research Project Grants;Resources;response;Role;Running;Rural;rural area;Rural Community;rural counties;Rural Health;rural underserved;school based health center;school district;Schools;Service provision;Services;Shapes;Site;social determinants;social health determinants;Social Work;sociologist;Structure;Students;Surveys;Time;Transportation;underserved community;Uninsured Medical Expense;Universities;urban setting;urgent care;Vaccination;Variant;Visit;Youth

PROJECT_TITLE: School Based Health Centers - An approach to address health disparities among rural youth.


NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Mental Illness;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: TALLAHASSEE

ORG_NAME: FLORIDA STATE UNIVERSITY

ORG_STATE: FL

PHR: Project Narrative Social determinants of health influence the progression of Cardiometabolic syndrome (CMetS) disease among individuals with comorbid mental health challenges. Integrated care approaches that address the unique challenges of people with both mental health disorders and CMetS in a culturally relevant manner will likely reduce adverse health outcomes and increase effective disease management. The proposed research will examine the influence of social determinants on mental health and cardiometabolic syndrome risk factor measures among individuals with co-morbid mental health challenges and cardiometabolic syndrome.

PI_NAMEs: DARK, TYRA  (contact)

PROGRAM_OFFICER_NAME: JOHNSON, JARRETT AINSWORTH

PROJECT_TERMS: Address;adverse outcome;Affect;analytic epidemiology;Anxiety;Anxiety Disorders;anxiety-related disorders;Back;Big Data;black men;black women;burden of illness;cardiometabolism;Characteristics;Clinical Management;Communities;community based participatory research;community building;community partners;comorbidity;Complex;Computer Models;cultural competence;Darkness;Data;Data Analyses;Data Collection;design;Development;disability;Disease;Disease Management;Disparity;disparity reduction;Economics;epidemiologic data;Epidemiology;epidemiology study;Equity;ethnic minority;Ethnic Origin;evidence base;Evidence based intervention;Eye;Feedback;Foundations;Future;Goals;Health;Health Care Costs;health disparity;health equity;Health Personnel;Healthcare;Individual;integrated care;Intervention;Managed Care;Maps;Measures;Medical;member;Mental disorders;Mental Health;Mentored Research Scientist Development Award;Methodology;Methods;Minority;minority communities;Minority Groups;Modeling;Not Hispanic or Latino;optimal treatments;Outcome;outcome prediction;Pattern;Persons;Population;Population Group;Positioning Attribute;Prevalence;Process;Process Assessment;Psyche structure;Race;racial disparity;Research;Research Personnel;resilience factor;Resources;Risk;Risk Factors;Science;Scientist;skill acquisition;skills;social determinants;social health determinants;social influence;Specific qualifier value;Syndrome;System;Techniques;Testing;Training;Translating;Trust;underserved minority;Visualization;Voice;Work

PROJECT_TITLE: Utilizing mixed methods to understand social determinants of successful disease management among populations with comorbid cardiometabolic syndrome and anxiety disorder


NIH_SPENDING_CATS: Behavioral and Social Science;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE The proposed study has the potential to impact both clinical and public health practice by improving minority health and health equality. Asian American women have the highest prevalence of gestational diabetes mellitus (GDM) among all racial and ethnic groups and there is substantial heterogeneity in GDM prevalence across Asian subpopulations. Applying an integrative approach leveraging metabolomics, lifestyles, and social determinants of health, the proposed study will elucidate mechanisms of the drastic disparities and heterogeneity in GDM and inform precision prevention to mitigate GDM risk and associated health sequelae for the high-risk Asian Americans.

PI_NAMEs: CHEN, LIWEI  (contact);ZHU, YEYI

PROGRAM_OFFICER_NAME: LAI, GABRIEL Y

PROJECT_TERMS: Acculturation;Asian;Asian Americans;Asian population;Biological;built environment;California;Central obesity;Chinese;Clinical;cohort;Cohort Studies;cost efficient;Data;deprivation;design;diabetes control;Diagnosis;Diet;Disparity;early pregnancy;Electronic Health Record;Environment;epidemiology study;ethnic disparity;Ethnic Origin;Ethnic Population;Filipino;Food;Functional disorder;Gestational Diabetes;Goals;Health;health data;health equality;Heterogeneity;High Prevalence;high risk;improve minority health;Individual;individualized prevention;Japanese;Knowledge;Language;Life Style;lifestyle factors;Mediating;Metabolic;Metabolic Pathway;metabolomics;Molecular;Neighborhoods;Not Hispanic or Latino;novel;Participant;Pathway interactions;Physical activity;Population;Pregnancy;Pregnancy Complications;pregnant;Prevalence;Prevention;Prevention strategy;programs;Prospective cohort;Public Health Practice;racial disparity;racial population;Research;Resources;Risk;Risk Factors;Role;Sample Size;Sampling;screening program;segregation;Serum;Sleep;social determinants;Social Environment;social health determinants;socioeconomic disadvantage;Socioeconomic Factors;Surveys;systematic review;tool;treatment strategy;United States;United States National Institutes of Health;Validation;Vietnamese;White Women;Woman;Work;α-Fetoproteins

PROJECT_TITLE: Elucidating the high and heterogeneous risk of gestational diabetes among Asian Americans: an integrative approach of metabolomics, lifestyles, and social determinants

STUDY_SECTION: RPPH

STUDY_SECTION_NAME: Reproductive, Perinatal and Pediatric Health Study Section[RPPH]