ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: PROJECT NARRATIVE Our innovative multicultural, multilingual, multichannel educational campaign (MICEO) on HPV related cancers reaches diverse audiences of adolescents and young adults in the African American, Hispanic/Latino and Chinese communities of Los Angeles. We collaborate with federally qualified health centers (FQHCs) and multicultural community-based organizations in partnerships that engage adolescents and young adults in a participatory manner in the creation of targeted messaging regarding HPV delivered via social media and outdoor media placements. Our MICEO campaign is expected to reduce pervasive HPV related cancer disparities in communities at risk.

PI_NAMEs: LERMAN, CARYN  (contact)

PROJECT_TERMS: Acceleration;Administrative Supplement;Adolescent;Adolescent and Young Adult;Adult Children;African;African American;African American population;Age;Anus;Artificial Intelligence;Artificial Intelligence platform;Asian;Attitude;Behavior;Belief;Black church;boys;cancer education;cancer health disparity;Cancer Vaccines;Catchment Area;Cervical;Cervix Uteri;Child;Chinese;Chinese American;Clinic;Clip;Collaborations;college;Communication;Communities;community advisory board;Community Health Aides;community organizations;community partners;community partnership;County;Data;design;Development;Education;Education and Outreach;Educational Materials;Effectiveness;Electronics;Elements;Evaluation;evidence base;Facebook;Family;Federally Qualified Health Center;Female;Female Adolescents;Feminization;Focus Groups;Health;health literacy;Hispanic;Hispanic Populations;HPV vaccine hesitancy;Human Papilloma Virus Vaccination;Human Papilloma Virus Vaccine;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;Immigrant;improved;Indigenous;Individual;innovation;Instagram;Intervention;Knowledge;Language;Latin America;Latina Population;Latino;Latino Population;Life;Los Angeles;low health literacy;Low income;low socioeconomic status;male;Male Adolescents;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Media Campaign;Medical;men;Misinformation;Monitor;Multilingualism;Multimedia;Oropharyngeal;Outcome;outreach;Pacific Islander;Parents;Participant;peer;penis;Production;programs;recruit;Reporting;Research;Resistance;Resources;Risk;Safety;Services;Sex Bias;side effect;Site;social;social media;Social Network;Surveys;Television;Testing;Time;tool;Training;Translations;tribal community;Underserved Population;Universities;University of Southern California Norris Cancer Center;Vaccination;vaccine acceptance;Vaccines;Vagina;Virus;Vulva;Work;young adult;Youth


ADMINISTERING_IC: CA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Lung Cancer;Prevention;Rural Health;Social Determinants of Health

ORG_CITY: RICHMOND

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: OVERALL: PROJECT NARRATIVE The mission of the Massey Cancer Center (MCC) is to reduce the state cancer burden for all Virginians by addressing the confluence between biological, social, and policy drivers through high-impact, cutting-edge research; person-centered care across the continuum, from prevention through survivorship; community integration; and training the next generation of community-centric researchers and healthcare professionals. The core of this mission has been supported by the National Cancer Institute’s Cancer Center Support Grant (CCSG) since 1975, and the MCC is seeking renewal of this award for another five years. The CCSG supports efforts across the MCC senior and programmatic leadership; administration; community outreach and engagement; cancer research training and education coordination; promotion of center-wide diversity, equity, and inclusion; shared resource support and management; clinical research infrastructure; and developmental funding to supporting team-based, transdisciplinary research strategies focused on well-defined, catchment area priorities.

PI_NAMEs: WINN, ROBERT A. (contact)

PROGRAM_OFFICER_NAME: BELIN, PRECILLA L

PROJECT_TERMS: Academia;Academic Medical Centers;Address;African American;Algorithms;anti-cancer research;Appointment;Area;authority;Award;Basic Science;Behavioral;Biological;Biometry;Black race;Cancer Biology;Cancer Burden;Cancer Center;Cancer Center Support Grant;Cancer Control;cancer health disparity;Cancer health equity;cancer prevention;Cancer Research Project;Cancer Survivorship;cancer therapy;career development;Caring;Catchment Area;Charge;Cities;Clinical;clinical implementation;Clinical Research;Clinical Sciences;Clinical Trials;cohort;Collaborations;college;Communities;Community Clinical Oncology Program;community engagement;Community Integration;Community Outreach;County;Crime;data acquisition;Data Analyses;Death Rate;Development;Developmental Therapeutics Program;Disparity;driving behavior;Education;Education and Outreach;Educational process of instructing;electronic medical record system;Ensure;equity, diversity, and inclusion;ethnic minority;Ethnic Origin;Excess Mortality;Faculty;Flow Cytometry;Fostering;Funding;Geography;Goals;Growth;Health;health disparity;Health equity research;Health Policy;Health Professional;Health Promotion;Health system;Home;Hot Spot;Housing;improved;Incidence;Individual;innovation;Institution;Intervention;Intervention Trial;Investments;Knockout Mice;Leadership;lipidomics;Malignant Breast Neoplasm;Malignant neoplasm of gastrointestinal tract;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant Neoplasms;Massey Cancer Center at the Virginia Commonwealth University;medically underserved;member;Mentors;metabolomics;Methodology;Microscopy;Mid-Atlantic Region;Minority;Mission;Modeling;multidisciplinary;National Cancer Institute;neighborhood disadvantage;next generation;Obesity;Outcome;Patient Care;Peer Review;person centered;Policies;Population Sciences;Positioning Attribute;Poverty;Prevention;Prevention approach;Primary Care;Production;Productivity;programs;Publications;Race;racial minority;recruit;Reporting;Research;research and development;Research Design;Research Infrastructure;Research Institute;Research Personnel;Resource Sharing;Resources;Rural;rural area;Schools;Science;Scientist;Screening for cancer;Services;Smoking;smoking-related cancer;social;social health determinants;social media;socioeconomic diversity;socioeconomics;Specialist;Speed;Strategic Planning;Students;success;survivorship;Technology;Tissues;Tobacco;Training;Training and Education;Transgenic Organisms;Translations;Underrepresented Minority;underserved area;United States Health Resources and Services Administration;Universities;Virginia;Vision

PROJECT_TITLE: Social Media Action to Reach, Teach and Educate Greater Richmond, VA, 2.0 (SMARTER-VA 2.0)

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


ADMINISTERING_IC: DC

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Bioengineering;Eye Disease and Disorders of Vision;Hearing Loss;Nanotechnology;Neurosciences;Rare Diseases;Usher Syndrome

ORG_CITY: CHICAGO

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE The senses of hearing and balance rely on tip-link protein filaments that pull on transduction ion channels to transform mechanical stimuli into electrochemical signals that can be processed by the brain. Mutations to the proteins forming the tip link and the transduction channel complex have been shown to cause deafness in humans and animal models. Here we propose to use structural and computational tools to gain insights into how the inner-ear proteins forming the tip link and the transduction channel complex function in normal and impaired hearing.

PI_NAMEs: SOTOMAYOR, MARCOS  (contact)

PROGRAM_OFFICER_NAME: FREEMAN, NANCY

PROJECT_TERMS: Aminoglycosides;Animal Model;Architecture;Atomic Force Microscopy;Binding;Binding Proteins;biophysical analysis;biophysical techniques;Brain;Cadherins;Calcium;Calcium and Integrin Binding Protein 2;Calcium Binding;Calcium-Binding Proteins;CDH23 gene;cellular transduction;Closure by clamp;Communication;Complex;Computational Technique;computerized tools;Consensus;Cryoelectron Microscopy;deafness;dimer;Dimerization;Elasticity;Electrophysiology (science);Equilibrium;Event;experimental study;Extracellular Domain;Filament;genetic deafness;Goals;Hair;Hair Cells;Head Movements;Hearing;hearing impairment;Homology Modeling;Human;human model;improved;Inner Hair Cells;insight;Integral Membrane Protein;Integrin Binding;Ion Channel;Ions;Knockout Mice;Labyrinth;Length;Link;link protein;Lipids;Mass Spectrum Analysis;mechanical force;mechanical stimulus;Mechanics;Mechanoreceptor Cell;mechanotransduction;Mediating;member;Membrane;Membrane Potentials;Membrane Proteins;microscopic imaging;Modeling;Molecular;Molecular Conformation;molecular dynamics;Molecular Structure;monomer;Mus;mutant;Mutation;N-terminal;nanomechanics;Nature;Nuclear Magnetic Resonance;ototoxicity;PCDH15 gene;Perception;Pore Proteins;potassium ion;Probability;Process;Property;Protein Family;protein function;Proteins;Regulation;response;Rest;Role;Sensory;Sensory Disorders;Set protein;Signal Transduction;simulation;sound;Spectrum Analysis;Speed;Spottings;Stretching;structural determinants;Structural Models;Structure;Testing;vibration

PROJECT_TITLE: Nanomechanics of inner-ear hair-cell transduction

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


NIH_SPENDING_CATS: Cancer;Clinical Research;HPV and/or Cervical Cancer Vaccines;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunization;Infectious Diseases;Prevention;Sexually Transmitted Infections;Social Determinants of Health;Vaccine Related

ORG_CITY: MEMPHIS

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

ORG_STATE: TN

PHR: PROJECT NARRATIVE Childhood cancer survivors are a high-priority, underserved population for HPV vaccination because they are less likely to be vaccinated and more likely to develop second cancers caused by HPV as adults when compared to the general population. This project will use an iterative, participatory, and collaborative approach to leverage, build on, optimize, and expand an HPV vaccination campaign for childhood cancer survivors to include peer-to-peer patient family experienced and clinician education and training.

PI_NAMEs: ROBERTS, CHARLES  (contact)

PROGRAM_OFFICER_NAME: ROBERSON, SONYA

PROJECT_TERMS: Address;Administrative Supplement;Adult;Award;Awareness;Cancer Center;cancer education;Cancer Etiology;Catchment Area;childhood cancer survivor;Collaborations;collaborative approach;Communication;Communities;Comprehensive Cancer Center;Computerized Medical Record;Data;Disparity;Elements;Ensure;Evaluation;experience;Family;General Population;health literacy;Human Papilloma Virus Vaccination;Human Papillomavirus;improved;Infrastructure;innovation;Knowledge;Measures;mobile application;Monitor;online resource;Outcome;Patient Education;Patients;peer;Positioning Attribute;Printing;process evaluation;Resources;Saint Jude Children's Research Hospital;Second Primary Cancers;social media;Spanish;Survivors;System;Testing;Training and Education;Trust;Underserved Population;Vaccinated

PROJECT_TITLE: P30 Administrative Supplement for Multi-Channel Communication Campaigns for Improvements in Cancer Education and Outcomes (MICEO) in Underserved Populations


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: NARRATIVE The proper assembly of membrane proteins as folded subunits or macromolecular complexes, is of critical importance to cellular physiology, yet we do not have a fundamental understanding of the physical reasons why membrane proteins assemble in the hydrophobic environment of the membrane. In this project, we are studying the equilibrium dimerization reaction of the CLC-ec1 Cl-/H+ antiporter as a model system to dissect the thermodynamic driving forces underlying membrane protein association in lipid bilayers. The results from this study will identify the molecular mechanisms for how protein sequence, lipid composition and general anesthetics modulate stability, and thereby lay down a physical foundation for the development of new strategies aimed at correcting stability defects in membrane protein folding diseases.

PI_NAMEs: ROBERTSON, JANICE L (contact)

PROGRAM_OFFICER_NAME: TAYLOR, VERONICA

PROJECT_TERMS: alpha helix;Amino Acid Sequence;antiporter;Binding;Biological Models;Cell membrane;Cell Physiology;Cells;CLC Gene;Computer Models;computer studies;Computing Methodologies;Defect;Development;dimer;Dimerization;Dissociation;driving force;enthalpy;Entropy;Environment;Equilibrium;Exhibits;experimental study;Fatty Acids;Fluorescence;Fluorobenzenes;Foundations;Free Energy;General anesthetic drugs;Grain;Hydrophobicity;interfacial;Kinetics;Laboratories;Link;Lipid Bilayers;Lipids;Macromolecular Complexes;Measurement;Measures;Membrane;membrane assembly;Membrane Proteins;Methods;Microscopy;Modeling;Molecular;molecular dynamics;molecular modeling;Mutation;novel;Nutrient;pharmacologic;Phase;physical model;Physiological;Physiology;Property;protein folding;protein structure;Protein-Folding Disease;Proteins;Reaction;Regulation;Research Design;Role;Route;Sampling;self assembly;single molecule;Solvents;Specificity;Sterols;Structure;Temperature;Theoretical model;theories;Thermodynamics;Time;Tryptophan;wasting

PROJECT_TITLE: Driving forces of membrane protein assembly in membranes


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Immunotherapy;Infectious Diseases;Microbiome;Patient Safety;Prevention;Wound Healing and Care

ORG_CITY: DAVIS

ORG_DEPT: DERMATOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

ORG_STATE: CA

PHR: Surgical site infections pose a serious threat to public health. In this project, we plan to determine why antibiotics are not as effective in controlling infection in immunocompromised patients. We also propose to develop novel (antibiotic-free) therapies to control surgical site infections.

PI_NAMEs: SHAFIKHANI, SASHA H (contact)

PROGRAM_OFFICER_NAME: XU, ZUOYU

PROJECT_TERMS: Address;Allergic Reaction;Animal Model;Animals;Antibiotic Prophylaxis;Antibiotic Resistance;Antibiotic Therapy;Antibiotics;antimicrobial;Bacterial Infections;bactericide;Behavior;Biological;Biological Availability;Cessation of life;Clostridium difficile;combat;cost;cytotoxicity;Data;Death Rate;Development;diabetic;diabetic rat;dysbiosis;Effectiveness;effectiveness evaluation;emerging antibiotic resistance;Focal Infection;glycemic control;gut microbiota;Health;Health Expenditures;Hospitalization;Immune;Immune response;Immune system;Immune System Diseases;Immunocompetent;Immunocompromised Host;Immunomodulators;immunomodulatory therapies;Impairment;Implant;improved;in vivo;Infection;Infection Control;Inflammasome;Inflammatory Response;Innate Immune Response;Innate Immune System;interest;Knowledge;Laboratories;Leukocytes;Link;Long-Term Effects;Mediating;Methods;Modeling;Molecular;Morbidity - disease rate;Muscle;Mycoses;Nervous System Disorder;Neutropenia;neutrophil;novel;novel strategies;Ohio;Operating Rooms;Operative Surgical Procedures;Oxygen;pathogen;Pattern;Pattern recognition receptor;Perioperative;Phagocytes;Physiological Processes;Play;prophylactic;Pseudomonas aeruginosa;Public Health;Risk;Role;Shapes;side effect;Site;skills;standard of care;Staphylococcus aureus;Sterilization;Surgical Wound Infection;synergism;Systemic infection;systemic inflammatory response;Techniques;Testing;Therapeutic;tissue repair;Tissues;United States Dept. of Health and Human Services;Universities;ventilation;Virus Diseases;wound

PROJECT_TITLE: Role of immune system in prophylaxis antibiotic's surgical site infection control

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


FUNDING_MECHANISM: NON SBIR/STTR CONTRACTS

NIH_SPENDING_CATS: Antimicrobial Resistance;Clinical Research;Clinical Trials and Supportive Activities;Infectious Diseases

ORG_CITY: FREDERICK

ORG_NAME: DYNPORT VACCINE COMPANY, LLC

ORG_STATE: MD

PI_NAMEs: SHOCKEY, GRAIG  (contact)

PROJECT_TERMS: Antibiotic Resistance;Bacterial Infections;Clinical Trials Unit;Combating Antibiotic Resistant Bacteria;Gram-Positive Bacteria;immune modulating agents;infectious disease treatment;Investigation;novel therapeutics;Phase I Clinical Trials;Therapeutic;Therapeutic Agents

PROJECT_TITLE: Task B1: Phase I Clinical Trial to Evaluate a Therapeutic for Antibiotic Resistant Gram Negative and Positive Bacterial Infections


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Cancer;Complementary and Integrative Health;Dietary Supplements;Endocrine Disruptors

ORG_CITY: MORRISVILLE

ORG_STATE: NC

PHR: Exposure to environmental factors that alter immune responses may lead to increases in the burden of disease in the human population. The scientific studies conducted under this contract investigate whether specific substances significantly alter immunity and the specific functions that are targeted in order to determine potential impact on human health

PI_NAMEs: BURLESON, FLORENCE  (contact)

PROJECT_TERMS: Affect;Animals;Antibody Response;Antigens;Archives;Aromatic Compounds;Autoimmune Diseases;Benchmarking;Bone Marrow;burden of illness;carcinogenicity;Chemical Agents;Chemical Exposure;Chemicals;Communicable Diseases;Complex;Contractor;Contracts;Cytology;Data;Data Analyses;Dermal;design;Development;developmental toxicity;dietary supplements;Dose;Echinacea Preparation;environmental agent;Environmental Risk Factor;Event;exposed human population;Exposure to;Food Additives;Health;Health Hazards;Hematopoietic;Human;Hypersensitivity;immune function;Immune response;immune system function;Immunity;Immunologic Techniques;Immunologics;immunoregulation;immunotoxicity;Immunotoxicology;In Vitro;in vivo;in vivo evaluation;Individual;Laboratories;Leadership;Management Information Systems;Manuscripts;Measures;Methods;Molecular;Neoplasms;neurotoxicity;Parameter Estimation;Pharmaceutical Preparations;Population;Predictive Value;Process;programs;Publications;Reporting;reproductive;reproductive toxicity;Research;Resistance;respiratory;response;Sampling;Statistical Data Interpretation;Structure;System;Testing;Therapeutic Agents;timeline;Toxic effect;Toxicology;Translations;Work;Writing;Xenobiotics

PROJECT_TITLE: STUDIES TO EVALUATE THE POTENTIAL FOR ENVIRONMENTAL&THERAPEUTIC AGENTS TO INDUCE IMMUNOTOXICITY - In vivo


NIH_SPENDING_CATS: Prevention

PHR: Exposure to environmental factors that alter immune responses may lead to increases in the burden of disease in the human population. The scientific studies conducted under this contract investigate whether specific substances significantly alter immunity and the specific functions that are targeted in order to determine potential impact on human health.

PROJECT_TERMS: 3-Dimensional;Agreement;Allergens;Allergic Contact Dermatitis;allergic response;Animals;Autoimmune Diseases;Biological Assay;burden of illness;Cells;Chemical Agents;Chemicals;Classification;Collaborations;Communicable Diseases;Contractor;Contracts;Data Analyses;Dermal;Development;dietary supplements;environmental agent;Environmental Risk Factor;Event;exposed human population;Exposure to;Food Additives;Funding;Genes;hazard;Hazard Identification;Health;Health Hazards;Hematopoietic;Human;Hypersensitivity;immune function;Immune response;immune system function;Immunity;Immunologic Techniques;Immunologics;immunoregulation;Immunosuppression;immunotoxicity;Immunotoxicology;In Vitro;in vitro Model;Japan;keratinocyte;Laboratories;Lung;Measures;Methods;Modeling;Molecular;National Institute of Environmental Health Sciences;Neoplasms;Peer Review;Peptides;Pharmaceutical Preparations;Population;Predictive Value;programs;Protocols documentation;Reaction;Reporting;Research;Resistance;respiratory;response;Risk Assessment;Running;screening;Skin;Structure;Techniques;Testing;Therapeutic Agents;Tissue Model;Toxicology;Translations;Validation;Vendor;Work;Xenobiotics

PROJECT_TITLE: STUDIES TO EVALUATE THE POTENTIAL FOR ENVIRONMENTAL&THERAPEUTIC AGENTS TO INDUCE IMMUNOTOXICITY - In vitro immunomodulation


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Endocrine Disruptors;Immunotherapy;Infectious Diseases

PROJECT_TERMS: Affect;Age;Animals;Antibodies;Antigens;Aromatic Polycyclic Hydrocarbons;Autoimmune Diseases;burden of illness;CD28 gene;CD3 Antigens;CD8-Positive T-Lymphocytes;Cell-Mediated Cytolysis;Chemical Agents;Chemicals;Communicable Diseases;Contracts;COVID-19;COVID-19 susceptibility;crosslink;cytokine;Data;Dermal;Development;Dexamethasone;dietary supplements;Environment;environmental agent;Environmental Risk Factor;Ethnic Origin;Event;experimental study;exposed human population;Exposure to;Female;Food Additives;Future;Gender;Health;Health Hazards;Hematopoietic;Human;Hypersensitivity;Immune;immune function;Immune response;immune system function;Immunity;Immunologic Techniques;Immunologics;Immunophenotyping;immunoregulation;Immunosuppression;Immunosuppressive Agents;immunotoxicity;Immunotoxicology;In Vitro;in vitro Model;in vivo;Individual;Influenza;Intrinsic factor;Leukocytes;Liver;male;Manuscripts;Measures;Mediating;Metabolic;Methods;Molecular;Mus;Natural Killer Cells;Neoplasms;Parents;Peptides;peripheral blood;Pharmaceutical Preparations;Phase;Population;Predictive Value;Predisposition;Production;programs;Research;Resistance;respiratory;response;Risk;Sampling;SARS-CoV-2 antigen;sex;Solubility;Statistical Models;Structure;System;T memory cell;T-Cell Activation;T-Cell Receptor;Testing;Therapeutic Agents;Toxicology;Translations;trend;Viral;Virus;Virus Diseases;Whole Blood;Xenobiotics

PROJECT_TITLE: Enabling risk-based testing through characterization of environmentally induced immune dysregulation and susceptibility to the SARS-CoV2 virus and COVID-19


ADMINISTERING_IC: OH

ED_INST_TYPE: UNIVERSITY-WIDE

FUNDING_MECHANISM: OTHERS

IC_NAME: NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH

ORG_CITY: ROLLA

ORG_NAME: MISSOURI UNIVERSITY OF SCIENCE & TECHNOLOGY

PHR: PROJECT NARRATIVE The U.S. mining industry remains one of the most dangerous and challenging environments for workers according to the Bureau of Labor Statistics (BLS), and the Mine Safety and Health Administration (MSHA). BLS and MSHA show that mining fatality rate is five times higher than other U.S. industries with an average of 36 fatalities per year within 2009 and 2018. This research initiative will reduce miners’ risk of traumatic injuries and fatalities in underground mine emergencies via new wireless communication, improved human-robot interactions, and refuge alternatives, and mine fire and explosions response and evacuation management.

PI_NAMEs: ALAGHA, LANA Z;AWUAH-OFFEI, KWAME ;BAKER, DENISE A;FRIMPONG, SAMUEL  (contact);JOHNSON, CATHERINE E;MADRIA, SANJAY ;NADENDLA, VENKATA S;PERRY, KYLE ;SHERIZADEH, TAGHI ;SILVA CASTRO, JHON ;XU, GUANG

PROJECT_TITLE: Research, Technological Innovations and Human Factors for Effective Miner Self-Escape from Underground Mine Emergencies


ADMINISTERING_IC: HL

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Cancer;Cardiovascular;Heart Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: SAN DIEGO

ORG_NAME: VALA SCIENCES, INC.

PHR: FDA guidelines stipulate that all new drugs be tested for dangerous side-effects on the heart as part of preclinical research; however, the current tests are poorly predictive of both dangerous and safe drugs leading to unwarranted attrition and dangerous drugs reaching clinic. Human cardiomyocytes derived from donor tissue (iPSC-derived cardiomyocytes) are widely considered to hold great promise for clinical trial in a dish studies of drug cardiotoxicity. This STTR proposal is to commercialize a high throughput platform to accurately identify drug candidates that have cardiac side effects, in particular adding the ability to detect the type of primary heart cell damage common with anti-cancer drugs in a fully automated (high throughput) robotic assay for the first time, to improve the efficiency of preclinical research and the safety of human clinical trials, which will also likely have the added benefit of reducing animal research.

PI_NAMEs: PRICE, JEFFREY H. (contact)

PROGRAM_OFFICER_NAME: ADHIKARI, BISHOW B

PROJECT_TERMS: Action Potentials;Address;Aging;American;Animal Experimentation;Animal Model;Animal Testing;Animals;anti-cancer therapeutic;Antineoplastic Agents;Arrhythmia;Artificial Intelligence;Biological Assay;Calcium;calcium indicator;cancer recurrence;cancer survival;Cancer Survivor;cancer therapy;cancer type;Cardiac;Cardiac Myocytes;Cardiomyopathies;Cardiotoxicity;cardiovascular risk factor;Cardiovascular system;cell injury;Cell membrane;Cell Membrane Permeability;Cells;cellular imaging;Cessation of life;chemotherapy;Clinic;Clinical;clinical predictors;clinical trial in a dish;Clinical Trials;commercialization;Complex;compound 30;Contract Services;Contractile Proteins;cost;cytotoxicity;Dangerousness;detection assay;Development;dosage;Dose;drug candidate;drug development;drug discovery;Drug Industry;drug testing;Female;Fluorescence;Goals;Growth;Guidelines;Heart;heart cell;Heart Diseases;high throughput screening;Hour;Human;human induced pluripotent stem cells;Image;Image Cytometry;Impairment;improved;In Vitro;Incubated;induced pluripotent stem cell derived cardiomyocytes;insight;instrument;Kinetics;Label;Lead;lead series;male;Malignant Neoplasms;manufacture;manufacturing scale-up;Marketing;Measures;Methods;Microscopy;Mitochondria;Motion;Myocardium;Myopathy;novel therapeutics;Outcome;Pathologic;Performance;Pharmaceutical Preparations;Pharmacologic Substance;Phase;Population;pre-clinical;Pre-Clinical Model;pre-clinical research;Production;Protocols documentation;Publications;Publishing;Quality Control;Recording of previous events;Recurrent tumor;Reporting;Research Contracts;response;Risk Assessment;Robotics;Safety;Sales;Sarcoplasmic Reticulum;scale up;Science;screening;screening services;Sensitivity and Specificity;side effect;Small Business Technology Transfer Research;Source;Specificity;Speed;System;Technology Transfer;Testing;Therapeutic;therapeutic candidate;Time;Tissue Donors;tool;Toxic effect;Treatment Side Effects;validation studies;voltage

PROJECT_TITLE: Combined Cardiomyopathy, e.g., of Cancer Chemotherapeutics, and Proarrhythmia for Cardiotoxicity Clinical Trials-in-a-Dish (CTiD) with iPSC-Derived Cardiomyocytes


NIH_SPENDING_CATS: HIV/AIDS;Infectious Diseases;Pediatric;Pediatric - AIDS;Prevention

ORG_CITY: KENSINGTON

ORG_NAME: ADVANCED BIOSCIENCE LABORATORIES, INC.

PI_NAMEs: SILVERA, PETER  (contact)

PROJECT_TERMS: Address;Adolescent;AIDS prevention;animal model development;Childhood;co-infection;Collaborations;Communities;Contraceptive Agents;Contracts;Development;Devices;Educational workshop;Extramural Activities;Formulation;HIV;Investigator-Initiated Research;Modeling;National Institute of Allergy and Infectious Disease;novel therapeutics;Pediatrics;pre-clinical;Prevention;Private Sector;product development;Research;research clinical testing;research study;Research Support;Resources;Science;Services;therapeutic development

PROJECT_TITLE: Participation in a Workshop on Development of Animal Models Supporting Pediatric Formulation Development


NIH_SPENDING_CATS: HIV/AIDS;Infectious Diseases;Nutrition;Pediatric;Pediatric - AIDS;Prevention

PROJECT_TERMS: AIDS prevention;Childhood;co-infection;Collaborations;Communities;Contraceptive Agents;Contracts;Development;Devices;Disease;Extramural Activities;HIV;improved;Investigator-Initiated Research;Medicine;National Institute of Allergy and Infectious Disease;novel therapeutics;Pediatrics;Pharmacologic Substance;pre-clinical;prevent;Prevention;Private Sector;product development;Research;research clinical testing;research study;Resources;Science;Services;Taste Buds;Taste Perception;Technology;therapeutic development

PROJECT_TITLE: Expertise in Using Bitter Taste Receptor Blockers to Improve the Palatability of Pediatric Medicines: Blocker Discovery


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: CHARLESTON

ORG_NAME: RALPH H JOHNSON VA MEDICAL CENTER

ORG_STATE: SC

PHR: Narrative Behavioral health problems among Veterans have raised awareness of the critical need for more reliable, effective, and accessible ways to recognize those in need, direct them to help, and ensure that they receive the best evidence-based care available. AboutFace is a novel peer education program that features the personal stories of Veterans and is designed to improve Veterans’ likelihood of engaging in PTSD specialty care. Using a randomized controlled study design we propose to compare the efficacy of AboutFace relative to standard care for improving treatment engagement and outcomes. Additional data from VA providers will provide valuable information on wide scale implementation and dissemination of AboutFace. If AboutFace increases access of services, data will have broad implications for overcoming barriers to care for Veterans with PTSD and other stigmatized conditions.

PI_NAMEs: GRUBAUGH, ANOUK L (contact);HAMBLEN, JESSICA L

PROJECT_TERMS: Attitude;Award;Awareness;barrier to care;behavioral health;Caring;Clinic;Clinical;comorbidity;comparative efficacy;Data;design;Development;digital;Disease;Dissemination and Implementation;Education;education resources;Educational Materials;Enrollment;Ensure;evidence base;Evidence based treatment;experience;feasibility trial;follow-up;Funding;Future;future implementation;Goals;Grant;Health Services Accessibility;Healthcare;help-seeking behavior;implementation strategy;Improve Access;improved;indexing;Intake;Intervention;Interview;Learning;Location;medical specialties;Mental Depression;Mental Health;Mental Health Services;Methodology;Methods;Military Personnel;novel;optimism;Outcome;peer;Persons;Pilot Projects;Post-Traumatic Stress Disorders;practice setting;Process;programs;Provider;Quality of life;Randomized;randomized, controlled study;Randomized, Controlled Trials;Recommendation;Research;Research Design;Resources;Risk;Role;service delivery;Services;social stigma;standard care;Stigmatization;Strategic Planning;stress related disorder;Symptoms;treatment as usual;Trust;United States Department of Veterans Affairs;Update;usability;Veterans;Veterans Health Administration;Visit

PROJECT_TITLE: Randomized Controlled Trial of AboutFace: A Novel Video Storytelling Resource to Improve Access, Engagement, and Utilization of Mental Health Treatment among Veterans with PTSD

STUDY_SECTION_NAME: HSR-4  Mental and Behavioral Health[HSR4]


NIH_SPENDING_CATS: Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Social Determinants of Health

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE The US health care system leads the world in administrative complexity and its associated costs. Cancer is a complex and often high-acuity condition with persistent disparities in health outcomes, making cancer care delivery a priority setting for assessing patient administrative burdens and identifying solutions. The proposed research uses qualitative, survey, and claims data in a sequential mixed methods analysis that will enable the measurement and diagnosis of administrative burden across cancer care settings and produce evidence identifying and motivating actionable organizational or policy targets for clinical leaders and policymakers.

PI_NAMEs: KYLE, MICHAEL ANNE (contact)

PROGRAM_OFFICER_NAME: CROSWELL, JENNIFER

PROJECT_TERMS: Adherence;Antineoplastic Agents;Architecture;cancer care;cancer recurrence;cancer therapy;care coordination;care delivery;care outcomes;career development;Caregivers;Caring;Characteristics;chemotherapy;Clinical;Communities;Complex;Comprehensive Cancer Center;cost;Data;data repository;Dedications;design;Development;Diagnosis;Doctor of Philosophy;Education;Emergency department visit;Equity;Failure;Financial cost;Focus Groups;Future;Goals;Guidelines;Health;health disparity;Health Policy;Health Services Accessibility;Health system;Healthcare Systems;high risk;Hospitalization;improved;Inequity;informal caregiving;innovation;insight;Knowledge;Link;Low income;Malignant Neoplasms;Managed Care;marginalization;marginalized population;Measurement;Measures;medication compliance;Mentors;Methods;Modality;novel;Oncology;Oral;Outcome;outreach;patient engagement;Patients;Persons;Pharmacy facility;Phase;Policies;Policy Maker;Prevalence;Process;programs;Property;Proxy;Psychometrics;Quality of Care;Recommendation;recruit;Reporting;repository;Research;Research Personnel;Respondent;response;Role;Services;Site;Stress;success;Supportive care;Survey Methodology;Surveys;theories;Time;Training;Validation;Work

PROJECT_TITLE: Patient Administrative Burden in Cancer Care Delivery


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Eye Disease and Disorders of Vision;Genetics;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: BIRMINGHAM

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE Mutations in the ADAM9 gene lead to loss of vision in human and veterinary patients. The proposed research utilizes genetically modified mouse models to address the pathophysiological mechanisms underlying photoreceptor degeneration due to the loss of ADAM9. Identifying these mechanisms is critical for developing therapeutic interventions aiming to prevent vision loss in affected patients.

PI_NAMEs: LEWIS, TYLOR ROBERT (contact)

PROGRAM_OFFICER_NAME: NEUHOLD, LISA

PROJECT_TERMS: 3-Dimensional;Address;Adhesions;Affect;aged;Biology;Blindness;canine model;Canis familiaris;career;career development;Cell Adhesion;Cell Adhesion Molecules;cell type;Cellular biology;Communication;cone-rod dystrophy;Data;Disease;Disintegrins;electron tomography;Electroretinography;Exhibits;experimental study;extracellular;Extracellular Matrix;Faculty;Functional disorder;Funding;Future;Gene Delivery;Gene Expression;Gene Modified;Genes;Goals;Health;Human;Immunoprecipitation;insight;Knock-out;Knockout Mice;Lead;Leadership;Light;Location;Mass Spectrum Analysis;member;Mentors;Metalloproteases;Methods;Molecular;mouse model;Mus;Mutation;Pathologic;Pathology;Patients;Peptide Hydrolases;Phase;Phenotype;photoreceptor degeneration;Photoreceptors;Preparation;prevent;Protein Family;protein function;Proteins;Proteolysis;Proteome;Proteomics;Research;Research Personnel;Retina;Retinal Degeneration;Retinal Detachment;Retinal Diseases;Retinitis Pigmentosa;Role;Site;skills;Structural defect;Structure of retinal pigment epithelium;Techniques;Testing;Therapeutic;Therapeutic Intervention;Training;training opportunity;United States National Institutes of Health;Universities;Visual System;Wild Type Mouse;Work

PROJECT_TITLE: The role of ADAM9 in retinal health and disease

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Dementia;Genetics;Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects;Prevention;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: BOSTON

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

ORG_STATE: MA

PHR: Project Narrative Traumatic brain injury induced chronic traumatic encephalopathy and vascular dementia are two major forms of aging related neurodegenerative diseases affecting millions of Americans. The goal of this proposal is to investigate a conserved and early molecular mechanism driving neurodegeneration in both diseases and to evaluate the preclinical therapeutic potential to target this mechanism. Understanding of this molecular mechanism and therapeutic assessment may provide insight into the disease progression and early therapeutic intervention to prevent dementia in traumatic brain injury induced chronic traumatic encephalopathy and vascular dementia.

PI_NAMEs: QIU, CHENXI  (contact)

PROGRAM_OFFICER_NAME: OPANASHUK, LISA A

PROJECT_TERMS: Advisory Committees;Affect;Age;Age of Onset;age related neurodegeneration;Aging;aging brain;Alzheimer's Disease;Alzheimer's disease patient;American;Amyloid beta-Protein;Attenuated;Automobile Driving;Behavior;Behavioral;Bilateral;Biology;Brain;Brain Injuries;career;Carotid Stenosis;Cell Culture Techniques;cell type;Cells;cerebral hypoperfusion;cerebrovascular;Cessation of life;Chronic;chronic traumatic encephalopathy;Clinic;Clinical;Cognitive;conditional knockout;Data;Dementia;Dependovirus;Development;Disease;Disease Progression;Early Intervention;Environment;Equilibrium;excitatory neuron;excitotoxicity;gene repression;Genetic;Genetic Screening;Genetic Transcription;Goals;Grant;healthy aging;Human;Hypoxia;Impaired cognition;In Vitro;Individual;Induced pluripotent stem cell derived human neuron;Induced pluripotent stem cell derived neurons;inhibitor;insight;Knock-out;Knockout Mice;Lead;MAPK10 gene;medical schools;Mentors;minimally invasive;Modeling;Molecular;Molecular Conformation;mouse model;multidisciplinary;Mus;Nerve Degeneration;Neurodegenerative Disorders;Neuronal Hypoxia;Neurons;neuropathology;neuroprotection;Nuclear;overexpression;Pathogenicity;Pathologic;Pathology;Patients;Phase;Phosphorylation;Phosphotransferases;pre-clinical;preservation;prevent;programs;Proline;Protein Kinase;Proteome;proteotoxicity;Publishing;Research;Resistance;response;Risk Taking;Role;single nucleus RNA-sequencing;spatiotemporal;Stress;Stroke;Symptoms;tau conformation;tau mutation;tau Proteins;tau-1;TBI treatment;Testing;Therapeutic;Therapeutic Intervention;Toxic effect;Training;transcription factor;Transcription Repressor;transcriptome;transcriptomics;Traumatic Brain Injury;United States National Institutes of Health;Vascular Dementia

PROJECT_TITLE: Cis proline directed proteotoxicity in the early development and therapy of traumatic brain injury and vascular dementia


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Contraception/Reproduction;Endocrine Disruptors;Mental Health;Microbiome;Neurosciences;Pediatric

ORG_CITY: HADLEY

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF MASSACHUSETTS AMHERST

PHR: PROJECT NARRATIVE Triclosan is a nearly ubiquitous exposure that has been phased out in some but not all consumer products due to recognition of its potential deleterious effects, including adverse neurobehavioral development. The proposed research will clarify the potential for triclosan to impact adolescent neurobehavior and elucidate the role of the gut microbiome and its metabolites in this association. This work has the potential to identify modifiable determinants and health effects of the adolescent gut microbiome.

PI_NAMEs: LAUE, HANNAH ELIZABETH (contact)

PROGRAM_OFFICER_NAME: DZIERLENGA, ANIKA LIN

PROJECT_TERMS: Academic achievement;Address;Adolescence;Adolescent;Adolescent Behavior;Adult;Affect;Age;antimicrobial;Anxiety;Attention;Attention deficit hyperactivity disorder;Award;Behavior;Behavior assessment;behavioral health;behavioral outcome;Biological;Birth;boys;Brain;Chemical Exposure;Child;Childhood;cohort;Complement;consumer product;Data;Data Collection;Dehydroepiandrosterone Sulfate;Development;Disease;DNA;dysbiosis;Educational workshop;Endocrine Disruptors;Endocrinology;Environment;environmental chemical;Environmental Epidemiology;Environmental Impact;Environmental Risk Factor;Estradiol;Etiology;Exposure to;fecal microbiome;Feces;Female;Follicle Stimulating Hormone;Future;girls;Gonadal Steroid Hormones;Growth;gut bacteria;gut microbiome;gut microbiota;gut-brain axis;Health;Hormonal;Hormonal Change;Hormones;Human;Individual;Infant;informant;interest;Learning;Link;Literature;Luteinizing Hormone;Measurement;Measures;Mediating;Mediation;Mental Depression;Mental Health;Mentors;Mentorship;Metabolism;metabolome;metagenomic sequencing;Methods;Microbe;microbial community;microbiome;microbiome alteration;microbiome analysis;microbiome composition;Modeling;National Institute of Environmental Health Sciences;neurobehavior;neurobehavioral;novel;Outcome;Participant;Perinatal;Phase;Play;Predisposition;Pregnancy;Problem behavior;prospective;Puberty;Research;Research Personnel;Research Priority;response;Risk Factors;Role;Serum;sex;Shapes;skills;Social Functioning;stool sample;Strategic Planning;Structure;Symptoms;System;Testing;Testosterone;Therapeutic;Toxic effect;Toxic Environmental Substances;Training;Triclosan;urinary;Visit;Work

PROJECT_TITLE: Triclosan, pubertal hormones, and the gut microbiome: implications for neurobehavior


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Brain Disorders;Clinical Research;Intellectual and Developmental Disabilities (IDD);Mental Health

ORG_NAME: DREXEL UNIVERSITY

PHR: The proposed research will lay a foundation for developing innovative, individualized interventions to improve nonverbal communication (NVC) experiences for autistic adults, based on the values and first-hand experiences of our target population. Improvements in NVC are necessary for downstream improvements in a range of func- tional contexts, resulting in overall improved life outcomes associated with autism in adulthood. This project is relevant to NIDCD’s mission pertaining to intervention, and to the NIH’s Interagency Autism Coordinating Com- mittee’s dual missions related to intervention and lifespan issues. This project will produce a set of specific, stakeholder-driven recommendations for designing and prioritizing NVC intervention development, opening new horizons for how NVC is conceptualized and addressed in autism.

PI_NAMEs: DE MARCHENA, ASHLEY BROOKE (contact)

PROGRAM_OFFICER_NAME: STORKEL, HOLLY LYNN

PROJECT_TERMS: Address;Adult;adult with autism spectrum disorder;Age;Area;Autism Diagnosis;autism spectrum disorder;autistic;Behavioral;career;Child;Collaborations;Communication;Communities;community consultation;Consultations;Data;Data Collection;design;Development;disability;Education;Employment;Evidence based intervention;experience;Eye;Facial Expression;follow-up;Foundations;Future;Gestures;Goals;Grant;Guidelines;Hand;Healthcare;Heterogeneity;improved;Individual;Individual Differences;individuals with autism spectrum disorder;innovation;Intervention;Interview;Investments;Knowledge;Language;Life;life span;Machine Learning;Maps;member;Mental Health;Methods;Mission;Modeling;National Institute on Deafness and Other Communication Disorders;Nature;Nonverbal Communication;novel;Outcome;Participant;Patient Recruitments;Patient Self-Report;Pattern;preference;prospective;Quality of life;Recommendation;recruit;Research;Research Methodology;Research Personnel;Resources;response;Sampling;skills;Structure;success;Surveys;Target Populations;Testing;therapy development;Toddler;tool;trait;United States National Institutes of Health;verbal;wasting

PROJECT_TITLE: Establishing Intervention Priorities for Nonverbal Communication in Autistic Adults

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Biotechnology;Cancer;Childhood Leukemia;Clinical Research;Gene Therapy;Genetics;Hematology;Immunotherapy;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_CITY: DUARTE

ORG_NAME: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE

PHR: NARRATIVE Acute myeloid leukemia (AML) is the most common form of acute leukemia in adults and most patients will die from their disease. Chimeric antigen receptor (CAR) T cell therapy is a novel form of cellular immunotherapy that has demonstrated great success in acute lymphoblastic leukemia, but translation of CAR T cell therapy to AML is complicated by (1) heterogeneous target antigen expression in AML, (2) expression of some target antigens on normal bone marrow cells in addition to AML, and (3) active immune-suppressive strategies employed by AML. The goals of this project are to generate multi-antigen-specific CAR T cells to eliminate AML by mitigating escape of antigen-negative leukemia, to identify sets of AML target antigens that are either non- myelosuppressive when targeted or that are myeloablative and can facilitate donor hematopoietic cell engraftment, and to further engineer CAR T cells to overcome AML-induced immune suppression.

PI_NAMEs: JAMES, SCOTT E (contact)

PROGRAM_OFFICER_NAME: BIAN, YANSONG

PROJECT_TERMS: Acute leukemia;Acute Lymphocytic Leukemia;Acute Myelocytic Leukemia;acute myeloid leukemia cell;Adult;Advisory Committees;Age;Allogenic;antigen binding;Antigen Targeting;Antigens;Autologous;Award;Bone Marrow;Bone Marrow Cells;Bone Marrow Purging;CAR T cell therapy;CD 200;CD19 gene;CD3 Antigens;Cell model;Cell Therapy;Cells;Cellular immunotherapy;chemotherapy;Chemotherapy and/or radiation;chimeric antigen receptor;chimeric antigen receptor T cells;Clinical;comorbidity;Complication;conditioning;CRISPR/Cas technology;cytokine;Data;design and construction;Detection;Diagnosis;Disease;efficacious treatment;engineered T cells;Engineering;Engraftment;exhaustion;Exhibits;Funding;Gene Modified;gene-targeted therapy;Generations;Genes;Genomics;Goals;graft vs host disease;Granzyme;Hematopoietic;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;Heterogeneity;humanized mouse;Immune;immune checkpoint;Immune Evasion;Immune response;Immune System Diseases;Immuno-Chemotherapy;Immunologic Stimulation;Immunosuppression;Immunotherapy;improved;In complete remission;Interleukin-12;interleukin-12 receptor;knowledge base;Laboratories;Legal patent;Leucine Zippers;leukemia;Leukemic Cell;leukemic stem cell;Malignant Neoplasms;Mediating;Memorial Sloan-Kettering Cancer Center;Mentorship;Molecular;Myelogenous;Myeloid-derived suppressor cells;Names;novel;novel therapeutics;patient derived xenograft model;Patients;perforin;Physicians;prevent;Process;programmed cell death ligand 1;Proteins;receptor;recruit;Recurrent disease;Regimen;Regulatory T-Lymphocyte;Relapse;Research;Resistance;Risk;Running;Safety;Scientist;Signal Transduction;Site;skills;Sorting;Specificity;stem cell engraftment;success;synthetic biology;System;T-Cell Activation;T-Cell Depletion;T-Cell Immunologic Specificity;T-Lymphocyte;Technology;tenure track;Toxic effect;Transforming Growth Factor beta;Transgenes;Translations;Transplantation;Transplantation Chimera;Tumor Antigens;United States National Institutes of Health;Viral;Viral Vector;Xenograft procedure

PROJECT_TITLE: Multi-antigen-specific CAR T cells to treat acute myeloid leukemia

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Assistive Technology;Behavioral and Social Science;Bioengineering;Brain Disorders;Burden of Illness;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Disability Research;Health Services;Mental Health;Neurodegenerative;Neurosciences;Palliative Care;Rehabilitation;Social Determinants of Health

ORG_CITY: Atlanta

ORG_NAME: MAPHABIT, INC.

ORG_STATE: GA

PHR: Caregiving is commonly acknowledged as one of the most stressful, under-recognized, under- paid, and under-supported jobs. The new MapHabit System Caregiver Training Program (CTP) will offer a technology-driven caregiver training platform that will train caregivers to be more knowledgeable about memory and dementia while also learning to better manage their own stress and their quality of life needs. In this way, caregivers can be more innovative in their care strategies using person-centered wellness plans and thoughtful decision processes. Informed patient care reinforces effective caregiving, reduces patient emergency visits, hospitalizations, caregiver dropout, and reduces overall burden on the healthcare system.

PI_NAMEs: GOLDEN, MATTHEW  (contact)

PROGRAM_OFFICER_NAME: HARRELL, ERIN

PROJECT_TERMS: acceptability and feasibility;Activities of Daily Living;Address;Alzheimer's disease related dementia;Brain;Brain region;burnout;Businesses;Calendar;care coordination;Caregiver Burden;caregiver education;caregiver quality of life;Caregiver support;Caregiver well-being;Caregivers;caregiving;Caring;Categories;Client satisfaction;Cognition;cognitive testing;commercialization;Communication;Communities;community building;cost;Critical Thinking;dashboard;Data;Dementia;dementia care;design;Dropout;Education;Effectiveness;Emergency Situation;Emotional;experience;Family;family burden;Family Caregiver;family caregiving;functional status;Guidelines;Habits;Health;Health care facility;Healthcare Systems;Home;Hospitalization;Hospitals;Impaired cognition;improved;Individual;Information Networks;innovation;Knowledge;Learning;Legal patent;Libraries;Life Experience;Managed Care;Maps;Marketing;Measurable;Measures;Memory;memory care;Mental Health;mHealth;Mobile Health Application;Motivation;Neurosciences;Occupations;Outcome;Participant;Patient Care;Patient Self-Report;Patient-Focused Outcomes;Patients;Performance;person centered;Personal Satisfaction;Persons;Phase;physical conditioning;Process;programs;Progressive Disease;Provider;Publishing;Quality of Care;Quality of life;response;Risk;Role;Schedule;Self Care;Self Perception;Self-Help Devices;skills;Small Business Innovation Research Grant;smart device;social;Social Network;Social support;Standardization;Stress;Support System;System;Systems Integration;Technology;technology platform;Training;Training Programs;usability;Visit;visual map;Voice;Wellness Center;Work

PROJECT_TITLE: An assistive-technology based Caregiver Training Program (CTP) to enhance caregiver effectiveness, well-being, and quality of life, which will improve overall care for individuals living with AD/ADRD.


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

ORG_STATE: NY

PHR: Genome duplication and repair require complex regulation. These regulatory mechanisms have broad influence on human diseases, ranging from developmental deficiency to cancers. Our work will use a combination of approaches to understand how cells ensure completion of replication, removal of DNA repair intermediates, and turning off the genome stress response at the right time.

PI_NAMEs: ZHAO, XIAOLAN  (contact)

PROGRAM_OFFICER_NAME: REDDY, MICHAEL K

PROJECT_TERMS: Area;biological adaptation to stress;Cells;Collaborations;Complex;coping;coping mechanism;Coupled;Cruciform DNA;Development;Disease;DNA;DNA biosynthesis;DNA Damage;DNA damage checkpoint;DNA Repair;DNA replication fork;DNA Structure;Ensure;Enzymes;Excision;Failure;Genetic Recombination;Genome;Genome Stability;Genomics;Goals;Growth;homologous recombination;human disease;insight;interdisciplinary approach;Joints;Licensing;Link;Malignant Neoplasms;Molecular;novel;novel strategies;Outcome;Pathway interactions;prevent;Process;Regulation;repaired;Research;response;Ribosomal DNA;Role;Signal Transduction;Site;Stress;Testing;Time;Work

PROJECT_TITLE: Regulation of genome replication, recombination, and stress response

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Digestive Diseases;Immunotherapy;Lymphatic Research;Maternal Health;Maternal Morbidity and Mortality;Pancreatic Cancer;Rare Diseases;Women's Health Research

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative We have shown that SEMA7A promotes multiple aspects of breast cancer progression, including proliferation, survival, invasion, and immune evasion. The F99 portion of this proposal (Aim 1) aims to investigate SEMA7A- mediated alterations to TAMs and T cells in the TME responsible for suppressing anti-tumor immunity and if targeting SEMA7A directly can impede tumor growth and immunoevasion. The K00 aspect of this application (Aim 2) proposes to identify novel mechanisms of immunoevasion in renal cell carcinoma and pancreatic ductal carcinoma, which may reveal novel targets for treatment to prevent metastases and prolong patient survival.

PI_NAMEs: ELDER, ALAN MICHAEL (contact)

PROGRAM_OFFICER_NAME: ELJANNE, MARIAM

PROJECT_TERMS: Acceleration;Adenocarcinoma Cell;Age;angiogenesis;anti-tumor immune response;Binding;Blood Vessels;breast cancer diagnosis;Breast Cancer Model;Breast Cancer Patient;breast cancer progression;Cancer Etiology;Cancer Model;career;CD8-Positive T-Lymphocytes;Cell Death;Cells;Cessation of life;Childbirth;Complex;Data;Data Set;density;design;Development;Distant Metastasis;Ductal Carcinoma;Ductal Epithelial Cell;experience;Future;Genomics;Goals;Grant;Immune;immune cell infiltrate;Immune Evasion;Immune system;Immune Tolerance;Immunosuppression;immunosuppressive macrophages;Immunotherapy;improved;In Vitro;insight;Integrins;intercalation;Intercellular Junctions;interest;Invaded;Knowledge;Laboratories;Link;Lymphangiogenesis;Lymphatic;Lymphatic Endothelial Cells;lymphatic vessel;Macrophage;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary gland;Mediating;Meditation;Mentors;Mining;Modeling;Monoclonal Antibodies;mouse model;Myeloid Cells;Neoplasm Metastasis;neoplastic cell;novel;Nulliparity;Pancreatic carcinoma;Pancreatic duct;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;Pancreatic Ductal Carcinoma;Patients;PD-1 blockade;podoplanin;Postdoctoral Fellow;postpartum breast cancer;pre-clinical;prevent;Probability;Prognosis;programmed cell death ligand 1;programmed cell death protein 1;Proliferating;Proteins;Proteomics;recruit;Recurrence;Renal Carcinoma;Renal Cell Carcinoma;reproductive;Research;Research Training;Resistance;Semaphorins;Signal Transduction;Signaling Molecule;skills;T cell infiltration;T-Cell Activation;T-Lymphocyte;targeted treatment;Testing;Tissues;tumor;Tumor Cell Invasion;Tumor Cell Migration;tumor growth;tumor heterogeneity;Tumor Immunity;tumor immunology;tumor microenvironment;tumor progression;Tumor Promotion;Tumor-associated macrophages;tumor-immune system interactions;Tumor-infiltrating immune cells;women's diagnosis;Women's mortality;Work

PROJECT_TITLE: Discerning mechanisms of semaphorin 7A-mediated tumor progression via immunoevasion


NIH_SPENDING_CATS: Cancer;Immunotherapy;Skin Cancer

ORG_CITY: SEATTLE

ORG_NAME: ALLEN INSTITUTE

ORG_STATE: WA

PHR: PROJECT NARRATIVE CD8+ T cells are crucial immune cells in our body’s fight against cancer and the degree to which CD8+ T cells traffic to and infiltrate the tumor greatly impacts cancer patient survival, especially melanoma patient survival. The F99 section of this proposal focuses on a new pathway existing between CD8+ T cells and a protein present at the tumor that negatively impacts CD8+ T-cell survival. Through mouse models, we will illuminate this mechanism to be able to block this negative interaction between CD8+ T cells and this suppressive protein to increase CD8+ T-cell survival, and ultimately improve melanoma patient survival.

PI_NAMEs: BENNION, KELSEY  (contact)

PROJECT_TERMS: American;Antitumor Response;Apoptosis;autocrine;Binding;cancer immunotherapy;cancer infiltrating T cells;Cancer Patient;CASP3 gene;CD8-Positive T-Lymphocytes;Cell secretion;Cell Separation;Cell Survival;cell type;Cells;Characteristics;Cutaneous Melanoma;cytokine;Cytoplasmic Tail;cytotoxic CD8 T cells;Data;Diagnosis;Disease;exhaust;Exhibits;Fc Receptor;Fibrinogen;fighting;Flow Cytometry;FOXP3 gene;Future;Gene set enrichment analysis;Goals;Grant;Hematopoietic;Homeostasis;Human;Immune;Immune response;Immunity;Immunotherapeutic agent;Immunotherapy;improved;Induction of Apoptosis;Infiltration;Inflammatory;Institution;Interferon Type II;Investigation;ITIM;Knock-out;Label;Ligand Binding;Ligands;Malignant Neoplasms;Mediating;Melanoma;Melanoma patient;Melanoma Tumor;Memory;Modeling;Molecular;mouse model;multiple omics;Mus;novel;Pathway interactions;patient response;Patient-Focused Outcomes;Patients;Peptides;Phenotype;Population;Postdoctoral Fellow;Production;Prognostic Marker;programmed cell death protein 1;Protein Secretion;Proteins;Proteomics;Publications;receptor;receptor binding;recruit;Regulation;Regulatory T-Lymphocyte;Research;Resistance;resistance mechanism;response;response biomarker;RNA;Role;Sampling;Signal Transduction;single-cell RNA sequencing;Skin;Skin Cancer;Source;success;Surface;T cell response;T-Cell Receptor;T-Lymphocyte;therapeutic target;TNF gene;transcriptomics;Transgenic Mice;Transgenic Organisms;transmission process;tumor;tumor microenvironment;Work

PROJECT_TITLE: Interrogating the Fgl2-FcgRIIB axis: A novel mechanism mediating apoptosis of tumor-specific memory CD8+ T cells


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: SAN DIEGO STATE UNIVERSITY

PHR: PROJECT NARRATIVE Physical Despite aims evidence-based based inactivity is prevalent and chronic diseases impact racial/ethnic minorities at a disproportionate rate. the availability of evidence-based physical activity interventions, few go to scale. The proposed study to develop and test implementation strategies to accelerate the uptake, spread, and sustainment of an physical activity intervention to improve health outcomes of underserved communities in faith- organizations.

PI_NAMEs: ARREDONDO, ELVA M (contact)

PROGRAM_OFFICER_NAME: MASTERSON, MARY YAA SEDEGAH

PROJECT_TERMS: Acceleration;Address;Adoption;Adult;Advocate;attentional control;Behavior;behavior change;Body mass index;Cancer Control;Cardiovascular Diseases;cardiovascular risk factor;Cessation of life;Chronic Disease;Church;Communities;community collaboration;Community Health Aides;community setting;contextual factors;Control Groups;Data;design;Diabetes Mellitus;Effectiveness;effectiveness/implementation trial;empowerment;ethnic minority;evidence base;Evidence based intervention;exercise intervention;expectation;experience;experimental study;Faith;Faith-based organization;follow-up;Gender Role;Guidelines;Health;Health Promotion;Hybrids;implementation framework;implementation strategy;improved;Individual;innovation;Intervention;Latina Population;Latino;Latino Population;Life Style;Maintenance;Malignant Neoplasms;member;Methods;moderate-to-vigorous physical activity;National Cancer Institute;Obesity;Organizational Change;organizational climate;Outcome;Pathway interactions;Personal Satisfaction;Physical activity;Physical activity scale;physical inactivity;Population;Practical Robust Implementation and Sustainability Model;prevent;program dissemination;programs;racial minority;Randomized;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;Research;Risk Factors;Role;scale up;social culture;sustainability framework;tailored messaging;Testing;Training;underserved community;uptake

PROJECT_TITLE: Enhancing capacity in faith-based organizations to implement and sustain multilevel innovations to improve physical activity

STUDY_SECTION: SIHH

STUDY_SECTION_NAME: Science of Implementation in Health and Healthcare Study Section[SIHH]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Infectious Diseases

ORG_CITY: SAN MARCOS

ORG_DEPT: CHEMISTRY

ORG_NAME: TEXAS STATE UNIVERSITY

ORG_STATE: TX

PHR: Public Health Statement: Bim1 is linked to increased virulence for Cryptococcus neoformans in a mouse meningitis infection model and participates in Cu-homeostasis. Related BLP genes are also present in several fungal pathogens affecting humans, including Coccidioides immitis, Histoplasma capsulatum, Talaromyces marneffei, and Aspergillus niger but little is known about how BLP sequence variation affects biological function. In the proposed research project, we will explore the active site design of this novel class of BLP copper trafficking proteins and explore their mechanism for Cu-delivery at the fungal cell surface; ultimately our findings will lead to a deeper understanding of the mechanisms of copper homeostasis in fungi which may be exploited for the development of future antifungal treatment strategies.

PI_NAMEs: PETERSON, RYAN LOREN (contact)

PROGRAM_OFFICER_NAME: ZHOU, YANG

PROJECT_TERMS: Active Sites;Affect;Affinity;Alleles;Amino Acid Sequence;anti-fungal agents;Ascomycota;Aspergillus niger;Basidiomycota;Binding;Binding Proteins;Biochemical;Biological Availability;Biological Process;Biology;Brain;C-terminal;Carrier Proteins;Cell membrane;Cell surface;Cell Wall;Coccidioides immitis;Coenzymes;Copper;copper-binding protein;Cryptococcus neoformans;Cytoplasm;Data;design;Development;Documentation;Drug Metabolic Detoxication;Electron Spin Resonance Spectroscopy;Electronics;Ensure;Environment;experimental study;extracellular;Extracellular Protein;Family;fungus;Future;Gene Proteins;Genetic;Genome;Goals;GPI Membrane Anchors;Health;Histoplasma capsulatum;Homeostasis;Homologous Gene;Homologous Protein;host colonization;Human;Infection;innovation;insight;Investigation;Ions;Kinetics;Ligand Binding;Link;Location;Lytic;man;Meningitis;Metals;Micronutrients;Mitochondria;Mixed Function Oxygenases;Modeling;Mus;novel;Outcome;oxidation;Oxidation-Reduction;Oxidative Stress;Oxygenases;pathogenic fungus;Pathway interactions;Pattern;Pichia;Plasma Cells;Polysaccharides;Process;Production;Property;protein expression;Protein Family;Protein Isoforms;protein transport;Proteins;prototype;Public Health;Pulse Radiolysis;Recombinants;Reporting;Research;Research Project Grants;Resistance;Respiration;Role;Saccharomyces cerevisiae;Sequence Analysis;Sequence Homology;Signal Transduction;Signaling Molecule;Site;small molecule;Solid;Source;Specificity;Superoxides;System;Talaromyces;Testing;trafficking;treatment strategy;uptake;Variant;virtual;Virulence;Work;Yeasts

PROJECT_TITLE: Mechanisms for cellular copper import via secreted cuproproteins


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Biotechnology

ORG_CITY: CLEVELAND

ORG_DEPT: PHYSICAL MEDICINE & REHAB

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: This is a supplemental budget request to organize the 2025 SPARC program annual meeting at Case Western Reserve University on March 12-13, 2025. Objective one is the scientific dissemination of current SPARC Phase 2 Projects. Objective two is to help attendees identify future translational activities for these current projects.

PI_NAMEs: FU, MICHAEL JOHN;KILGORE, KEVIN L. (contact)

PROGRAM_OFFICER_NAME: GROSS, BROOKS ANDREW

PROJECT_TERMS: Anatomy;Award;Budgets;Collaborations;Communities;Data;data resource;Development;Devices;Educational workshop;Engineering;Event;follow-up;forging;Funding;Future;Goals;Human;Knowledge Management;Maps;meetings;Mission;models and simulation;Nerve;neural;Peripheral;Persons;Phase;posters;Prize;programs;Reporting;Research;Research Personnel;Rotation;Scientist;Series;Services;Standardization;Technology;translational approach;translational goal;Travel;United States National Institutes of Health;Universities;Update;Work

PROJECT_TITLE: NIH SPARC Annual Meeting 2025

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(50)-R]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_DEPT: BIOLOGY

PHR: We propose to create a comprehensive resource for women’s health by studying the molecular characteristics of individual cells in the female reproductive system. Our cellular atlas will uncover the complex interactions of cells that determine reproductive health and help with therapeutic strategies.

PI_NAMEs: KIM, JUNHYONG  (contact);O'NEILL, KATHLEEN ELISE

PROGRAM_OFFICER_NAME: TINGEN, CANDACE M

PROJECT_TERMS: 3-Dimensional;Anatomic Models;Anatomy;Atlases;Basic Science;Biological Assay;Cell Communication;cell community;Cells;Cellular biology;Characteristics;Chromatin;Clinical;Complex;Data;Deposition;Discipline of obstetrics;female reproductive system;Fertility;Goals;Gynecology;Health;Human;Human Biology;Human BioMolecular Atlas Program;indexing;Individual;individual variation;Informatics;Location;Mammalian Oviducts;Maps;Metadata;Molecular;molecular scale;multimodality;Operative Surgical Procedures;Organ;Ovary;Physiological;Procedures;programs;Records;Reproductive Health;Reproductive Medicine;Reproductive system;Research Personnel;Resources;RNA;Sampling;single-cell RNA sequencing;structured data;System;Therapeutic;Tissue Sample;Tissues;transcriptomics;Uterus;Women's Health;Women's study

PROJECT_TITLE: Penn Center for Multi-scale Molecular Mapping of the Female Reproductive System


ED_INST_TYPE: SCHOOLS OF PHARMACY

ORG_CITY: WEST LAFAYETTE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: NARRATIVE This program will develop innovative synthetic methods and strategies for accessing fluorinated substructures commonly found in marketed drugs, therapeutic candidates, and biological probes. Further, the program will computationally and experimentally validate physicochemical and biophysical perturbations imparted by fluorinated substructures with the goal of delivering next-generation fluorinated therapeutic candidates with improved drug-like properties.

PI_NAMEs: ALTMAN, RYAN A (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TERMS: Affect;Alcohols;Alkenes;analog;Area;Biological;Biophysics;catalyst;design;Development;Drug Kinetics;drug market;Drug Stability;Electrochemistry;functional group;Goals;improved;In Vitro;in vivo;innovation;Ligands;Medicine;metabolic profile;Metabolism;Methodology;Methods;Modernization;Natural Products;next generation;novel therapeutics;Parents;Pharmaceutical Chemistry;Pharmaceutical Preparations;Pharmacodynamics;Phase;physical property;programs;Property;Proteins;Reaction;Reagent;Synthesis Chemistry;System;Therapeutic;therapeutic candidate;Transition Elements;Work

PROJECT_TITLE: Fluorination and Fluoroalkylation Strategies for Synthetic and Medicinal Chemistry


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Infectious Diseases

ORG_CITY: GAINESVILLE

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Project Narrative Streptococcus mutans is a common oral bacterium that is found around the world and is associated with tooth decay and extraoral infections like infective endocarditis, with annual related health care costs in the US alone exceeding 60 billion dollars. S. mutans produces several proteins that form insoluble amyloid aggregates during biofilm growth so it is important to understand how the amyloids form and are regulated to better treat and prevent disease. This research will characterize monomeric compared to amyloid structures of these proteins, and evaluate how other components within biofilm matrices, such as extracellular DNA and lipid membranes, impact amyloid formation.

PI_NAMEs: BRADY, L. JEANNINE  (contact);LONG, JOANNA R

PROGRAM_OFFICER_NAME: MCNEALY, TAMARA L

PROJECT_TERMS: Adherence;Aging;alpha synuclein;Amyloid;amyloid formation;amyloid structure;amyloidogenesis;B-DNA;Bacteria;Bacterial Adhesins;Behavior;beta pleated sheet;Binding;biophysical properties;Cardiolipins;Cell Density;Cell membrane;Cell surface;Cell Wall;Cellular Membrane;Childhood;Clinical;Collagen;Competence;cross reactivity;Dental caries;Dental Plaque;Detection;Disease;DNA;Dyes;Endocarditis;Environment;Evaluation;Exposure to;extracellular;Extracellular Matrix;Fiber;Funding;Genetic;Genus staphylococcus;Grant;Growth;Health Care Costs;Human;Huntington gene;Impact evaluation;In Situ;In Vitro;in vivo;Incidence;Infection;Infective endocarditis;interest;Laboratories;Left;Length;Life Cycle Stages;Ligands;Link;Lipids;Liposomes;Literature;Membrane Lipids;Methodology;Methods;microbial;Microbial Biofilms;microbial disease;microorganism;mitochondrial membrane;Monoclonal Antibodies;monomer;neuropathology;oral bacteria;Organism;Parents;Parkinson Disease;Pathogenesis;Pathologic;Pathology;Pathway interactions;Peptides;Phospholipids;Play;Ploidies;polypeptide;Post-Translational Protein Processing;prevent;protein aggregation;protein misfolding;protein protein interaction;protein purification;Proteins;Reporting;Research;Roentgen Rays;solid state nuclear magnetic resonance;sortase;Streptococcus;Streptococcus mutans;Structure;synuclein;Vesicle;Work;Z-Form DNA

PROJECT_TITLE: Functional amyloid formation in streptococcus mutans

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]


NIH_SPENDING_CATS: American Indian or Alaska Native;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research

ORG_CITY: OKLAHOMA CITY

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PI_NAMEs: JAMES, JUDITH A (contact)

PROGRAM_OFFICER_NAME: PEI, WUHONG

PROJECT_TERMS: Address;Advisory Committees;aging brain;Applications Grants;Arthritis;Autoimmunity;brain research;Budgets;Cancer Center;Cardiovascular Diseases;career;catalyst;Cherokee Nation;Chickasaw Nation;Child Health;Choctaw Nation of Oklahoma;Cities;Clinic;Clinical;Clinical Research;Clinical Sciences;Clinical Trials;Collaborations;college;Communication;Communications Personnel;Communities;Community Medicine;community organizations;Community Participation;community partners;Consultations;Development;Diabetes Mellitus;Educational workshop;Ensure;Evidence based practice;Eye;Fostering;Foundations;Funding;Geroscience;Goals;Grant;Health;health equity;Health Professional;Health Promotion;Health Sciences;Healthcare;Home;improved;Information Resources;Infrastructure;Institution;Investments;Laboratories;Lead;Leadership;Malignant Neoplasms;Manuscripts;Marketing;Medical center;Medical Research;meetings;Mental Health;Mentors;Mentorship;Mission;National Institute of General Medical Sciences;Newsletter;Obesity;Oklahoma;Online Systems;patient population;Patients;Performance;Personnel Management;Physicians;podcast;Policies;Practice based research;Press Releases;Primary Health Care;Privatization;Procedures;Process;Productivity;programs;Public Health;Publications;recruit;Reporting;Research;Research Activity;Research Personnel;Resource Sharing;Resources;response;Schools;Services;Strategic Planning;Substance abuse problem;success;Supervision;symposium;synergism;Teleconferences;tool;Training;Training and Infrastructure;Translational Research;translational research program;tribal community;tribal health;tribal Nation;Tribes;Underrepresented Populations;Underserved Population;United States Department of Veterans Affairs;United States National Institutes of Health;Universities;webinar;Writing

PROJECT_TITLE: Administrative Core


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Dissemination and Implementation Research;Health Services;Hematology;Pain Research;Prevention;Rare Diseases;Sickle Cell Disease

ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: PUBLIC HEALTH RELEVANCE: Individuals with sickle cell disease (SCD) often endure multiple acute pain crises throughout their lives and as they contend with chronic pain. Music Therapy is a promising, safe option response to chronic pain and anxiety, but future multi-site randomized trials are needed. Completion of the proposed R01 and the subsequent RCT (UG3/UH3) could provide critical evidence to support inclusion of MT as a chronic pain intervention for individuals with SCD.

PI_NAMEs: DUSEK, JEFFERY A (contact);JENERETTE, CORETTA M.

PROGRAM_OFFICER_NAME: CHIDEYA-CHIHOTA, SEKAI RUTENDO

PROJECT_TERMS: Acute Pain;Address;Adoption;Adult;American Society of Hematology;Anxiety;California;Cancer Center;Chronic;chronic pain;chronic pain management;Chronic pain syndrome;Clinic;Collaborations;comparison group;Control Groups;COVID-19 pandemic;Data;Data Collection;Data Coordinating Center;data quality;Development;early adolescence;Education;Educational Intervention;Effectiveness;electronic data;Enrollment;Etiology;feasibility research;Feasibility Studies;Future;Goals;Guidelines;Health education;Health Personnel;health related quality of life;Home;Hybrids;Impaired health;implementation evaluation;implementation facilitators;implementation outcomes;implementation process;improved;Individual;Intervention;intervention delivery;Interview;life span;Manuals;Measures;Mental Health;Music;Music Therapy;Nonpharmacologic Therapy;Pain;Pain interference;Pain management;Pain Management Method;Participant;participant retention;Patient Recruitments;Patients;Persons;pharmacologic;Pilot Projects;Population;Preparation;prisma;Procedures;Process;programs;Protocols documentation;Provider;psychosocial;public health relevance;Quality of life;Randomized;randomized trial;Randomized, Controlled Trials;Records;recruit;Research;Research Priority;Research Project Grants;response;Screening procedure;Self Efficacy;Sickle Cell Anemia;Site;Sleep disturbances;Social Functioning;South Carolina;Structure;success;Surveys;Therapeutic Intervention;Universities;University Hospitals;virtual;virtual delivery;Waiting Lists

PROJECT_TITLE: MULTIsite feasibility of MUSIc therapy to address Quality Of Life in Sickle cell disease (MULTI-MUSIQOLS)


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Clinical Research;HIV/AIDS

ORG_CITY: LUSAKA

ORG_COUNTRY: ZAMBIA

ORG_FIPS: ZA

ORG_NAME: UNIVERSITY OF ZAMBIA

PHR: Millions of persons with HIV in sub-Saharan Africa are now surviving for decades on treatment but are devel- oping chronic non-communicable disease complications that require new science and new directions in pre- vention, detection, and treatment. The University of Zambia (UNZA)-Vanderbilt HIV Research Training Partner- ship (UVP) has been extremely successful, achieving all its aims including supporting 11 UNZA PhD students, evaluating and facilitating a new structure for the UNZA PhD Program, and hosting two UNZA Visiting Faculty Scholars at Vanderbilt. We will deepen and extend the impact of UVP in catalyzing UNZA's research capacity by shifting the grant's primary leadership to UNZA, training five UNZA PhD students and four postdoctoral sci- entists, implementating UNZA's new postdoctoral fellowship program, adding two South-South partnerships with the University of the Witwatersrand and the Consortium for Advanced Research Training in Africa (CARTA), and establishing a Biostatistics Support Core service at UNZA.

PI_NAMEs: HEIMBURGER, DOUGLAS CORBETT;MUTALE, WILBROAD  (contact)

PROGRAM_OFFICER_NAME: BANSAL, GEETHA PARTHASARATHY

PROJECT_TERMS: Advocacy;American;Area;career development;Collaborations;community advisory board;Competence;Country;Development;Doctor of Philosophy;Educational workshop;Evaluation;Faculty;Funding;Future;Geography;global health;Goals;Grant;higher education;HIV;innovation;Institution;institutional capacity;interest;Lead;Leadership;Mentorship;Modeling;Needs Assessment;parent grant;parent project;Pathway interactions;Policies;Population Heterogeneity;post-doctoral training;Postdoctoral Fellow;Professional Competence;programs;Research;Research Personnel;Research Training;Rural;Scientist;skills;Strategic Planning;Structure;Students;Training;Training Programs;Underrepresented Populations;United States National Institutes of Health;Universities;urban area;Zambia

PROJECT_TITLE: UNZA-Vanderbilt Training Partnership for HIV-NCD Research (UVP-2)


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: HOUSTON

ORG_NAME: TEXAS SOUTHERN UNIVERSITY

PI_NAMEs: POON, IVY CHUI (contact)

PROGRAM_OFFICER_NAME: GARRIDO, CARLOS OSWALDO

PROJECT_TERMS: Adherence;Advertisements;Advisory Committees;Affect;African American population;Applications Grants;Area;Award;Behavioral;Behavioral Sciences;Bioinformatics;Biomedical Research;Cardiovascular Diseases;career development;Clinical;Clinical Sciences;Collaborations;college;Committee Members;Communities;community engagement;Community Networks;Competence;Core Facility;COVID-19;Data;Data Analytics;design;Development;Development Plans;Disease;Doctor's Degree;Educational workshop;Effectiveness;Electronic Mail;Eligibility Determination;Engineering;Equipment;Evaluation;Extramural Activities;Faculty;Feedback;Funding;Future;Goals;Government;Grant;gulf coast;Health Disparities Research;health disparity;Health Sciences;Hispanic Americans;HIV/AIDS;improved;Individual;Institution;interest;Leadership;Machine Learning;Malignant Neoplasms;Mathematics;Measures;Medical center;meetings;Mentors;Mentorship;Minority Groups;Minority Health Research;minority scientist;Modification;Native Americans;novel;Participant;Performance;Pharmacy facility;Pilot Projects;Population;Positioning Attribute;Postdoctoral Fellow;preference;Preparation;Productivity;professor;Program Development;Program Effectiveness;Program Evaluation;programs;recruit;Reduce health disparities;Reporting;Request for Applications;Research;Research Activity;Research Infrastructure;Research Personnel;Research Proposals;Resources;Science;Scientist;Senior Scientist;Series;Services;skills;success;symposium;synergism;Technology;Texas;Time;Training;Travel;Underrepresented Minority;United States National Institutes of Health;Universities;web site;webinar;Writing

PROJECT_TITLE: Investigator Development Core


ADMINISTERING_IC: AA

ED_INST_TYPE: GRADUATE SCHOOLS

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Machine Learning and Artificial Intelligence;Substance Misuse

ORG_CITY: LOS ANGELES

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative The proposed R01 application builds upon the extensive work from our laboratory on the development of a maximally translational task for drinking motivation in humans. This study will test the three dimensions of the Addiction Neuroclinical Assessment (ANA) for their respective effects on motivation for alcohol in individuals with alcohol use disorder.

PI_NAMEs: RAY, LARA A. (contact)

PROGRAM_OFFICER_NAME: FALK, DANIEL EVAN

PROJECT_TERMS: 3-Dimensional;addiction;alcohol craving;alcohol reinforcement;alcohol reward;alcohol seeking behavior;alcohol use disorder;Alcoholic beverage heavy drinker;Alcohols;analytical method;Attention;Basic Science;Behavior;Behavioral Sciences;Biological Markers;biomarker development;Blood specimen;Blood Tests;blood-based biomarker;breath alcohol measurement;Clinical;clinical application;Clinical Sciences;clinical translation;Collection;Computer Assisted;Corticotropin;craving;Data Analytics;Data Set;Development;Dimensions;discounting;disease classification;Disease Progression;drinking;Emotional;Ethanol;Executive Dysfunction;Growth;Human;Hydrocortisone;hypothalamic-pituitary-adrenal axis;Impairment;incentive salience;Individual;Inflammation;Infusion procedures;innovation;insight;Interleukin-10;Interleukin-6;intravenous administration;Laboratories;Longterm Follow-up;Machine Learning;machine learning model;Methodology;Modeling;Motivation;negative mood;Neurobiology;Outcome;Outcome Assessment;Participant;Patient Self-Report;Peripheral;phenomenological models;Phenotype;pre-clinical;pre-clinical research;preference;Protocols documentation;Reporting;Research;response;Rewards;Role;Sampling;Schedule;Self Administration;Severities;Side;Staging;System;Testing;therapy development;TNF gene;Translational Research;Translations;Work

PROJECT_TITLE: Translational underpinnings of motivation for alcohol in humans

STUDY_SECTION: ARM

STUDY_SECTION_NAME: Addiction Risks and Mechanisms Study Section[ARM]


ADMINISTERING_IC: EB

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Lung;Lung Cancer;Prevention

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

PHR: PROJECT NARRATIVE Lung cancer is the deadliest form of cancer and is diagnosed by performing biopsies with a bronchoscope; how- ever, this tool is limited in its ability to explore deep into the periphery of the lung, where cancer can remain undetected. This proposal focuses on the design, development, and validation of a novel soft surgical robot to address critical unmet needs within the world of lung cancer. These include increasing the depth of access in peripheral regions and improving navigability within the lungs, enhancing the precision and accuracy of tissue biopsies, and enabling for the first-time rapid diagnosis and simultaneous therapy in a single bronchoscopy pro- cedure to hasten cancer treatment and increase the rate of survival.

PI_NAMEs: RUSSO, SHEILA  (contact)

PROGRAM_OFFICER_NAME: BITTMANN, MORIA FISHER

PROJECT_TERMS: 3-Dimensional;Acceleration;Accidents;Address;Affect;Air;Algorithms;Anatomic Models;Anatomy;Area;Biopsy;Biopsy Specimen;blind;Breathing;Bronchi;Bronchial Tree;Bronchoscopes;Bronchoscopy;cancer diagnosis;cancer therapy;cancer type;Cause of Death;Cessation of life;Collaborations;Colon Carcinoma;Computer software;Computer Vision Systems;cost effective;Data;Death Rate;design;Development;Device or Instrument Development;dexterity;Diagnosis;Diagnostic;Diameter;Distal;Drug Delivery Systems;Drug Targeting;Early Diagnosis;Early treatment;Evaluation;experience;experimental study;fabrication;Family suidae;flexibility;Goals;Health Care Costs;image guided;improved;In Vitro;in vitro testing;instrument;Intervention;Intuition;Learning;Lesion;Location;Lung;Lung nodule;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant Neoplasms;Manuals;Marketing;Mechanics;Medical Device;miniaturize;Movement;Needles;novel;Operative Surgical Procedures;Patients;Performance;Peripheral;Positioning Attribute;preservation;Procedures;Pulmonology;Radial;rapid diagnosis;Reaction;Recording of previous events;Research;Risk;Robot;robot assistance;robot control;Robotics;Safety;Site;Stroke;success;Survival Rate;System;Technology;Therapeutic;Time;Tissue Sample;tissue trauma;Tissues;tool;tumor growth;United States;Validation;Vision;visual feedback;Visualization;Work

PROJECT_TITLE: Extending Reach, Accuracy, and Therapeutic Capabilities: A Soft Robot for Peripheral Early-Stage Lung Cancer

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Nutrition;Social Determinants of Health

ORG_CITY: ANN ARBOR

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative We will build on sophisticated technology that we have invented to measure how groups of animals interact with each other as well as with their surroundings during long-term, longitudinal studies of aging, and how these interactions affect demographic and molecular measures of health. These new technologies and experimental paradigms will push the limits of behavioral monitoring and analysis in any organism and will be used to investigate the molecular causes and consequences of social interactions on aging.

PI_NAMEs: PLETCHER, SCOTT  (contact)

PROGRAM_OFFICER_NAME: FU, YI-PING

PROJECT_TERMS: Acute;adverse outcome;Affect;Afferent Neurons;age related;age related changes;Aging;aging related;Animal Behavior;Animals;Assessment tool;Behavior;Behavior Control;Behavior monitoring;Behavioral;Biogenic Amines;Biological;Biological Markers;Biological Models;Cognitive aging;Collaborations;Computer software;Coupled;Data Analyses;design;Diet;dietary restriction;Dissection;Drosophila genus;Drosophila melanogaster;Ensure;Environment;Environmental Exposure;Environmental Risk Factor;Exhibits;experience;Exposure to;Fatty acid glycerol esters;feeding;fly;Food;Foundations;Frequencies;Future;Gene Expression;Genes;Genetic;genetic manipulation;Goals;Health;healthy aging;high dimensionality;Human;Individual;Influentials;innovation;Intervention;invention;Investigation;Knowledge;Laboratories;Learning;Life;life span;Light;Link;lipid metabolism;Long-Term Effects;Longitudinal Studies;Measurement;Measures;Mediating;metabolome;metabolomics;Methods;middle age;Molecular;mortality;Motivation;Movement;multidimensional data;neural circuit;Neurologic;Neurons;Neuropeptides;neurotransmission;new technology;Nutrient;Organism;Pathway interactions;Pattern;Phase;Physiological;Research;resilience;Resistance;response;Rewards;Scientist;Series;sex;Shapes;sleep pattern;social;Social Behavior;Social Conditions;Social Environment;social factors;Social Interaction;Stress;Structure;System;Technology;technology validation;Temperature;Testing;Time;tool;treatment group;Uncertainty;Work

PROJECT_TITLE: Systems and methods for molecular dissection of socio-environmental effects on aging


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Narrative In humans, the greater the social connectedness and socioeconomic status, the lower the burden of diseases and mortality rate. Unfortunately, the causal role of social context on aging-related diseases is difficult to ascertain because randomization is impossible/unethical. This project will develop rigorous socio-behavioral models and innovative assessment tools in laboratory mice, with the ultimate goal of identifying social factors affecting individual variability in aging processes, and socio-behavioral intervention to increase resilience.

PI_NAMEs: BARTOLOMUCCI, ALESSANDRO  (contact)

PROGRAM_OFFICER_NAME: GERALD, MELISSA S

PROJECT_TERMS: Acceleration;Address;Affect;Age;age acceleration;Aging;aging process;aging related;aging related disease;Algorithms;Animals;Assessment tool;Behavior;Behavior Therapy;Behavioral;Behavioral Model;Biological;Biological Models;burden of illness;Cell Aging;Cessation of life;Cognitive;comparative;Data;Death Rate;design;Development;Disease;DNA Methylation;Early Intervention;Energy Metabolism;environmental enrichment for laboratory animals;Epigenetic Process;Etiology;Experimental Designs;Female;flexibility;frailty;Functional impairment;Future;Genetic;genetic manipulation;Goals;Health;health determinants;healthspan;Human;human old age (65+);Impairment;improved;indexing;Individual;individual variation;innovation;insight;Intervention;Knowledge;Laboratories;Laboratory mice;Life Cycle Stages;life span;Link;Longevity;low socioeconomic status;male;Mammals;Measures;Modeling;Molecular;mouse model;Mus;Natural History;neglect;novel;Onset of illness;Pathogenicity;Phase;Physical Function;Physiological;Physiology;predictive modeling;Prevalence;prevent;promote resilience;Randomized;rate of aging;Research;resilience in aging;Role;Shapes;social;social adversity;Social Behavior;social deprivation;Social Environment;social factors;Social Functioning;Social Gradients;social health determinants;social influence;social integration;Social Interaction;Social isolation;Social Processes;social stress;Social support;Testing;Therapeutic;therapy design;Time;Translating;unethical;Vulnerable Populations;Water

PROJECT_TITLE: Mouse models for the influence of the social environment on health and aging


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Nutrition;Prevention

ORG_CITY: BAR HARBOR

ORG_NAME: JACKSON LABORATORY

ORG_STATE: ME

PHR: RELEVANCE TO PUBLIC HEALTH Aging is a chronic condition that afflicts all living systems; healthy vs. unhealthy aging can be measured using a frailty index which is often used in interventional studies. Here we propose to develop scalable frailty index using computer vision and machine learning in the context of genetically diverse mouse populations with diet- based interventions to mimics human aging. The resulting tool will strengthen the utility of animal models for behavioral and social research toward understanding how social and physical environmental factors contribute to aging processes and the etiology and progression of age-related conditions and diseases.

PI_NAMEs: KUMAR, VIVEK  (contact)

PROGRAM_OFFICER_NAME: COGLIATI, TIZIANA PAOLA

PROJECT_TERMS: Acceleration;Adopted;Affect;Age;age related;Aging;aging process;Animal Model;animal old age;Animals;Applied Research;Automation;Basic Science;Behavior;Behavioral;Behavioral Model;biological age;Biological Aging;Biological Assay;biological systems;Caloric Restriction;Chronic;Chronology;Clinical;Collaborations;Computer Vision Systems;Data;Data Set;Death Rate;Diet;Dietary Intervention;Disease;diverse data;drinking behavior;Environmental Risk Factor;Etiology;Fat-Restricted Diet;Fatty acid glycerol esters;Feeding behaviors;frailty;Future;Genetic;Gerontology;hands-on learning;Health;Health Status;healthy aging;Heterogeneity;High Fat Diet;high reward;high risk;Hour;Human;human model;improved;indexing;Individual;Intervention;Intervention Studies;Judgment;Letters;Longevity;Machine Learning;machine learning model;Manuals;Measures;Methods;Monitor;mortality;mortality risk;Mouse Strains;Mus;Nesting Behavior;novel;old mice;open field behavior;Organism;Outcome;Phase;Phenotype;Physiological;Physiology;Population;Population Heterogeneity;pre-clinical;preclinical study;Process;Public Health;Reproducibility;Research;Shock;Sleep;social;Social Behavior;sugar;System;Testing;The Jackson Laboratory;Therapeutic;Time;tool;Training;Translational Research;translational study;Visual

PROJECT_TITLE: Machine learning based frailty index for the genetically diverse mice


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Aging;Genetics;Sarcopenia

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

PHR: PROJECT NARRATIVE Sarcopenia is a debilitating age-related skeletal muscle wasting syndrome associated with poor quality of life and high health care utilization. Identifying the mechanisms underpinning sarcopenia is critical for developing pharmacologic therapies to enhance late-life health and function. The proposed work will interrogate the extent to which cellular senescence, a central aging mechanism, mediates skeletal muscle dysfunction and thus, may reveal a new druggable target for treatment or prevention of sarcopenia.

PI_NAMEs: ENGLUND, DAVIS A. (contact)

PROGRAM_OFFICER_NAME: LINDHURST, MARJORIE JEAN

PROJECT_TERMS: Address;Adult;Age;age related;aging mechanism;Anatomy;Bioinformatics;Biology;biomarker validation;blood-based biomarker;career;Cell Aging;Cell Cycle;Cell Cycle Arrest;Cell Nucleus;cell type;Cells;Chronology;Clinic;clinically relevant;Data;Disease;DNA Damage;Doxycycline;drug discovery;Drug Targeting;effective therapy;Epigenetic Process;Etiology;Fiber;Fibrosis;Foundations;Functional disorder;functional improvement;Funding;gain of function;Gene Expression Profiling;Giant Cells;Health;health care service utilization;Heterogeneity;Human;Image;improved;in vivo;Individual;insight;Knowledge;Label;late life;loss of function;Measures;Mediating;Mentors;Methods;Microscopy;mitochondrial dysfunction;Mitotic;Modeling;Molecular;molecular imaging;Mononuclear;mouse model;multiple omics;Mus;Muscle;muscle aging;Muscle Fibers;muscle form;Muscle satellite cell;muscle strength;Muscular Atrophy;new therapeutic target;novel;old mice;oncoprotein p21;overexpression;Personal Satisfaction;pharmacologic;Phase;Phenotype;Physical Function;Population;Positioning Attribute;postmitotic;Predisposition;Prevention;Process;programs;Property;Publishing;Quality of life;Research;Research Personnel;Research Training;Resolution;response;Role;sarcopenia;senescence;senescent cell;single-cell RNA sequencing;Skeletal Muscle;skeletal muscle wasting;skills;Stimulus;synergism;Techniques;Testing;Therapeutic;therapeutic target;Tissues;tool;Training;transcriptome;Transgenic Mice;Translating;translational research program;United States National Institutes of Health;Wasting Syndrome;Withdrawal;Work

PROJECT_TITLE: The role of cellular senescence in skeletal muscle loss and dysfunction


ORG_CITY: LA JOLLA

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: Project Narrative The proposed research is relevant to public health as there is still a gap in understanding maternal-infant pharmacology. The UCSD MPRINT Center of Excellence in Therapeutics will bring together basic and data scientists, pharmacologists and clinical researchers in a highly collaborative fashion to understand the impact of infant exposure to maternal antibiotic treatment via breastmilk on the metabolism of the drugs, microbiome and immune function. The proposed research will help create a national resource for expertise in maternal and pediatric therapeutics and is relevant to NICHD’s mission by furthering the field of pediatric developmental pharmacology and in working towards ensuring that “all children have the chance to achieve their full potential for healthy and productive lives”.

PI_NAMEs: BODE, LARS ;CHAMBERS, CHRISTINA ;NIZET, VICTOR ;TREMOULET, ADRIANA H (contact);TSUNODA, SHIRLEY M

PROGRAM_OFFICER_NAME: REN, ZHAOXIA

PROJECT_TERMS: Address;Ampicillin;Analytical Chemistry;Antibiotic Prophylaxis;Antibiotic Therapy;Antibiotics;Basic Science;Biological Assay;Breast Feeding;Breastfed infant;Centers of Research Excellence;Child;Childhood;Clinical;Clinical Pharmacology;Clinical Sciences;cohort;Collection;Cytochrome P450;Data;Data Science;Data Scientist;Development;Drug Kinetics;drug metabolism;Education;Enrollment;Ensure;enzyme activity;Enzymes;experience;Exposure to;Face;Faculty;Fostering;fundamental research;Growth and Development function;Hepatic;High Pressure Liquid Chromatography;Human;Human Milk;human milk oligosaccharides;Immune;immune function;Immune response;Infant;infant monitoring;infant outcome;Infection;Infrastructure;innovation;Laboratories;Lead;Leadership;Mass Spectrum Analysis;Metabolic;metabolome;metabolomics;microbiome;Milk;Mission;Molecular;Mothers;mouse model;National Institute of Child Health and Human Development;Near-Infrared Spectroscopy;Neonatal;non-invasive monitor;novel;Nutritional;Oligosaccharides;operation;Outcome;pathogen;pediatric pharmacology;Performance;Pharmaceutical Preparations;Pharmacology;pharmacometrics;physiologic model;Physiological;Pilot Projects;Pneumococcal vaccine;Productivity;programs;Protocols documentation;Public Health;Research;Research Infrastructure;Research Methodology;Research Personnel;Research Project Grants;Resources;response;Role;Sampling;Serum;Skin;Source;Stress;Technical Expertise;Technology;Therapeutic;Therapeutic Research;Training;training opportunity;Validation

PROJECT_TITLE: Optimization of Antibiotics in Mothers and their Breastfed Infants Using Pharmacomicrobiomic and Metabolomic Analyses