ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Clinical Research;Health Services;Lung;Neonatal Respiratory Distress;Patient Safety;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Rare Diseases

PHR: PROJECT NARRATIVE At least 50,000 infants per year have breathing problems because they were born early. The goal of this proposal is to assess the benefits/risks of outpatient diuretic medications, a commonly used therapy for these infants and young children.

PI_NAMEs: COLLACO, JOSEPH MICHAEL (contact)

PROGRAM_OFFICER_NAME: PILEGGI, ANTONELLO

PROJECT_TERMS: 2 year old;Acute;acute care;Adult;Adverse effects;Affect;age group;Alveolar;Benefits and Risks;Blood Vessels;Breathing;Bronchopulmonary Dysplasia;Caring;Child;Childhood;Chronic;chronic respiratory disease;Clinic;Clinical;cohort;Data;Development;Diuretics;Documentation;Edema;Educational workshop;Electrolytes;Emergency department visit;Enrollment;examination questions;experience;Gestational Age;Goals;Growth;Guidelines;Health;hospital readmission;Hospitals;Impairment;improved;Infant;infant outcome;Inpatients;Intercellular Fluid;interstitial;Knowledge;Life;life span;Light;Live Birth;Lung;Lung Diseases;lung health;lung injury;Measurement;Mechanics;Medical;National Heart, Lung, and Blood Institute;Neonatal Intensive Care Units;Nephrocalcinosis;Obstructive Lung Diseases;Osteopenia;Outcome;Outpatients;Patient-Focused Outcomes;Pharmaceutical Preparations;premature;Premature Infant;premature lungs;prenatal;pulmonary function;Pulmonary Hypertension;Questionnaires;Randomized, Controlled Trials;Registries;Research;Research Personnel;respiratory;Respiratory Disease;respiratory morbidity;Respiratory Signs and Symptoms;Role;Severities;side effect;Standardization;success;Symptoms;tertiary care;United States;Variant;virtual;Work of Breathing

PROJECT_TITLE: The Role of Outpatient Diuretic Therapy in Bronchopulmonary Dysplasia

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Pediatrics Study Section[CHHD-A]


ADMINISTERING_IC: CA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Genetics;Kidney Disease;Orphan Drug;Rare Diseases

ORG_CITY: STANFORD

ORG_COUNTRY: UNITED STATES

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_FIPS: US

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: Project Narrative The proposed research is relevant to public health because kidney cancer is one of the top 10 most common cancers in both men and women. The most common and aggressive subtype of kidney cancer is clear cell renal cell carcinoma (ccRCC), where the 5-year survival rate for patients with advanced disease remains only 11%. The proposed research is relevant to the mission of the NIH, and the NCI, because it will provide mechanistic insights into the mechanisms driving metabolic reprogramming in ccRCC through RNA methylation and will provide the foundation for a novel class of therapeutic agents in the treatment of this lethal disease.

PI_NAMEs: RANKIN, ERINN B (contact)

PROGRAM_OFFICER_NAME: MAAS, STEFAN

PROJECT_TERMS: 3-Dimensional;Address;advanced disease;Amino Acid Transporter;angiogenesis;Angiogenesis Inhibitors;Apoptosis;Automobile Driving;Biological Assay;Biological Markers;cancer cell;carboxylation;cell growth;Cell Line;Cell Survival;Cells;Clear cell renal cell carcinoma;Clinic;clinical development;Combined Modality Therapy;Compensation;Consumption;Data;demethylation;Development;Diagnosis;Disease;efficacy evaluation;epitranscriptomics;fat mass and obesity-associated protein;Foundations;Glutamine;Growth;human model;Hypoxia;Immunocompetent;Immunotherapy;inhibitor;innovation;insight;knock-down;Knowledge;loss of function;Magnetic Resonance Imaging;Malignant Epithelial Cell;Malignant Neoplasms;Maps;Mediating;men;Messenger RNA;Metabolic;Metabolism;metabolomics;Methylation;Mission;Modeling;Modification;Molecular;molecular imaging;Monitor;mouse model;mRNA Decay;multidisciplinary;novel;obesity treatment;objective response rate;Oncogenic;Operative Surgical Procedures;patient derived xenograft model;Patients;PET/CT scan;Phenocopy;Play;precision medicine;Prevalence;prognostic;Proliferating;Proteins;Public Health;Reader;Renal Carcinoma;Renal Cell Carcinoma;Research;Resistance;response;RNA;RNA methylation;Role;Safety;Signal Transduction;Site;stable isotope;Survival Rate;synthetic lethal interaction;Systemic Therapy;targeted cancer therapy;Testing;Therapeutic;Therapeutic Agents;therapeutic target;Time;time use;Translating;Translations;tumor;tumor growth;tumor metabolism;tumor microenvironment;Tumor Suppressor Proteins;Tumor Weights;United States National Institutes of Health;uptake;VHL gene;Von Hippel-Lindau Syndrome;Woman;Work;X-Ray Computed Tomography

PROJECT_TITLE: The role of the RNA demethylase FTO in metabolic reprogramming of renal cell carcinoma

STUDY_SECTION: CCB

STUDY_SECTION_NAME: Cancer Cell Biology Study Section[CCB]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Arthritis;Genetics;Osteoarthritis

ORG_CITY: CHAPEL HILL

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Relevance Osteoarthritis is the most common cause of chronic disability in older adults but treatments to slow the progression of the disease are lacking. The results from this project will provide new information about basic mechanisms relevant to joint tissue breakdown in osteoarthritis. This information is needed in order to discover new targets for slowing or stopping the progression of the disease.

PI_NAMEs: LOESER, RICHARD F (contact)

PROGRAM_OFFICER_NAME: WILLIAMS, JOHN

PROJECT_TERMS: age related;age-related disease;Aging;Alanine;Amino Acids;Antioxidants;Biology;Cell Aging;Cell Death;Cell model;cell type;Cells;Chondrocytes;Chronic disability;comparison control;Cysteine;cytokine;Degenerative polyarthritis;Development;Disease Progression;Engineering;Enzymes;Event;Exhibits;Family;Fibroblasts;Funding;Future;genetic approach;Genetic Transcription;Glutathione Disulfide;Goals;Human;Hydrogen Peroxide;in vivo;Inflammatory;innovation;Investigation;JNK-activating protein kinase;joint function;Joints;knock-down;Literature;Maintenance;MAPK8 gene;MAPK9 gene;Measures;Mediator;Mitochondria;Modification;mouse model;Mus;NADP;novel;novel therapeutics;older adult;overexpression;Oxidases;oxidation;Oxidation-Reduction;oxidative damage;Oxidative Stress;p38 Mitogen Activated Protein Kinase;Pathogenesis;Pathologic;Pathway interactions;peroxiredoxin;Phenotype;phosphoproteomics;Phosphorylation;Physiological;PRDX3 peroxidase;Production;Proteins;Proto-Oncogene Proteins c-akt;Reactive Oxygen Species;Reporter;Role;senescence;senescence associated secretory phenotype;senescent cell;senolytics;senomorphic;Severities;Signal Pathway;Signal Transduction;Signaling Protein;Sorting;Sulfhydryl Compounds;Supporting Cell;System;Tissues;tool;Transgenic Mice;Transgenic Organisms;TXNIP gene;Work

PROJECT_TITLE: Oxidative Stress and the Development of Osteoarthritis

STUDY_SECTION: SBSR

STUDY_SECTION_NAME: Skeletal Biology Structure and Regeneration Study Section[SBSR]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Genetics;HIV/AIDS;Infectious Diseases

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE In the absence of new therapeutic strategies, the goal of providing universal HIV-1 treatment and ending the HIV-1/AIDS epidemic is unattainable. HIV-1 persists in a stable reservoir of latently-infected cells, representing the major obstacle to achieving HIV-1 remission. As part of NIH’s mission to end the HIV-1 epidemic, this project seeks to understand whether the CARD8-inflammasome can be harnessed to eliminate infected cells, which may lead to control of HIV-1 without the requirement for lifelong treatment.

PI_NAMEs: SHAN, LIANG  (contact);SIMONETTI, FRANCESCO ROBERTO

PROGRAM_OFFICER_NAME: SHANKAR, UDAY K

PROJECT_TERMS: Acceleration;Acquired Immunodeficiency Syndrome;Aftercare;AIDS clinical trial group;Anti-Retroviral Agents;Antibodies;Antigens;antiretroviral therapy;Apoptosis;Automobile Driving;CASP1 gene;CD28 gene;CD4 Positive T Lymphocytes;Cell Death;cell killing;Cells;Chromatin;Clear Cell;Clinical;Clinical Research;Clinical Trials;Clonal Expansion;Clone Cells;cytokine;decay acceleration;Development;Dimerization;Dipeptidyl Peptidases;Disease remission;DNA;Down-Regulation;efavirenz;Epidemic;Euchromatin;exhaustion;experimental study;Face;Future;Genetic Transcription;Genomic Segment;Genomics;Goals;HIV;HIV-1;HIV-1 protease;Human;humanized mouse;Immune;immune clearance;Immune system;in vivo;Inflammasome;inhibitor;innovation;integration site;Intervention;Knock-in Mouse;latent HIV reservoir;Measures;Mediating;memory CD4 T lymphocyte;Mission;Monitor;mouse model;Mus;Mutation;Names;non-nucleoside reverse transcriptase inhibitors;novel;novel strategies;novel therapeutic intervention;Participant;Pattern recognition receptor;Peptide Hydrolases;Peripheral Blood Mononuclear Cell;Persons;Pharmaceutical Preparations;Phase;Plasma;Population;Population Dynamics;pre-clinical research;Predisposition;premature;pressure;Production;Productivity;programs;Proliferating;Proteins;Provirus Integration;Proviruses;Randomized;Regimen;Research;Resistance;RNA;RNA Sequences;Sampling;Shapes;Shock;T-Lymphocyte;Testing;Time;Tissues;United States National Institutes of Health;Variant;Viral;Viral Cytopathogenic Effect;viral DNA;Viral Load result;viral rebound;Viral reservoir;viral RNA;Virion;Virus;Virus Replication;Work

PROJECT_TITLE: Harnessing the CARD8 Inflammasome for HIV Reservoir Elimination


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Kidney Disease

ORG_CITY: Aurora

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative Vascular calcification is a major cause of death in patients with chronic kidney disease (CKD) who have higher levels of serum phosphate and saturated fatty acids (SFAs). This research will find therapeutic targets for vascular calcification and enhance our understanding of the molecular mechanisms by which CKD promotes lipotoxicity and vascular calcification.

PI_NAMEs: MIYAZAKI, MAKOTO  (contact)

PROGRAM_OFFICER_NAME: STABLEY, JOHN N

PROJECT_TERMS: Acids;Acyltransferase;Address;Affect;alpha-glycerophosphoric acid;Aorta;Apoptosis;attenuation;Autophagocytosis;Autophagosome;Binding;biological adaptation to stress;Blood Vessels;calcification;Cardiovascular Diseases;Cause of Death;Chronic Kidney Failure;Complex;coronary artery calcification;Cultured Cells;Cyclic AMP-Dependent Protein Kinases;Deacetylation;Dietary Component;Disease;Down-Regulation;effective therapy;endoplasmic reticulum stress;Enzymes;Epigenetic Process;Event;gene repression;Genetic Transcription;Goals;HDAC3 gene;human subject;In Vitro;in vivo;inhibition of autophagy;inorganic phosphate;Knockout Mice;Medial;Mediating;mineralization;Molecular;mouse model;Mus;new therapeutic target;Oleic Acids;Pathogenesis;Pathway interactions;Patients;pharmacologic;Phosphatidic Acid;Prevention strategy;Production;promoter;Reaction;Regulation;Repression;Repressor Proteins;Research;Saturated Fatty Acids;Scheme;screening;Serum;Signal Transduction;small molecule libraries;Smooth Muscle Myocytes;Stearic Acids;Stearoyl-CoA Desaturase;Therapeutic;therapeutic target;Transcription Repressor;Transcriptional Regulation;transmethylation;Vascular calcification;Vascular Smooth Muscle;Work

PROJECT_TITLE: The transcriptional control of vascular calcification in disease

STUDY_SECTION: AVI

STUDY_SECTION_NAME: Atherosclerosis and Vascular Inflammation Study Section[AVI]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Conditions Affecting the Embryonic and Fetal Periods;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: DURHAM

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: DUKE UNIVERSITY

PHR: PROJECT NARRATIVE Maternal and infant morbidity and mortality are public health crises, particularly among Black pregnant individuals in the United States. Clinical trials and community-engaged research that ensure diverse participant enrollment are needed to address health disparities and appropriately treat pregnant individuals. The Duke Clinical Center of the Maternal Fetal Medicine Units Network will lead and participate in clinical trials and research vital to decreasing the unacceptable rates of adverse outcomes and health disparities.

PI_NAMEs: HUGHES, BRENNA L. (contact)

PROGRAM_OFFICER_NAME: CHAKHTOURA, NAHIDA ABDO

PROJECT_TERMS: Address;adverse outcome;Area;bilingualism;black patient;Black race;Catchment Area;Chad;Child;Climate;Clinic;Clinical;Clinical and Translational Science Awards;clinical care;clinical center;Clinical Research;Clinical Trials;Cohort Studies;Collaborations;Collection;Communicable Diseases;Communication;Communities;community engaged research;Country;Data;Data Coordinating Center;data management;data sharing;Death Rate;design;disadvantaged background;Discipline of obstetrics;Disparity;diversity and inclusion;Enrollment;Ensure;Environment;Equity;evidence base;experience;follow-up;Fostering;Future;General Practitioners;Goals;health disparity;health equity;Healthcare;high risk;Home;improved;Individual;Infant;infant morbidity/mortality;Infrastructure;innovation;Institution;International;Lactation;Latinx;Lead;Location;marginalized population;Maternal Health;maternal morbidity;Maternal Mortality;Maternal-fetal medicine;Maternal-Fetal Medicine Units Network;mortality;Mothers;National Institute of Allergy and Infectious Disease;National Institute of Child Health and Human Development;neonatal care;neonatal health;neonatal morbidity;North Carolina;obstetric care;offspring;operation;Outcome;outcome disparities;outpatient facility;Participant;participant enrollment;patient population;Patients;Pediatrics;Perinatal;Perinatal Epidemiology;Persons;Pharmacology;Physicians;Population;Population Heterogeneity;Pregnancy;pregnancy health;pregnant;Premature Birth;Prevention;Process;Productivity;Protocols documentation;Public Health;Qualitative Methods;randomized trial;Recording of previous events;recruit;Reproducibility;Research;Research Design;Research Infrastructure;Research Methodology;Research Personnel;Resources;Risk;Satellite Centers;Science;Site;Southeastern United States;Specialist;Training;Translational Research;United States;Universities

PROJECT_TITLE: Duke University Maternal-Fetal Medicine Units (MFMU) Network Clinical Center


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: CLEVELAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

ORG_STATE: OH

PHR: PROJECT NARRATIVE Glioblastoma is an incurable primary brain tumor. The Wnt pathway is frequently dysregulated in many cancers, including glioblastoma, underscoring it as an important therapeutic target. This work will reveal a novel mechanism by which Wnt signaling is activated independent of Wnt ligand-receptor binding. If successful, the findings of this study will provide new strategies to improve treatment for glioblastoma.

PI_NAMEs: YU, JENNIFER S (contact)

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: axon guidance;beta catenin;Binding;Blood Vessels;Bypass;Cell Nucleus;Clinical Trials;clinically significant;Complex;Cues;Data;Development;Dissection;Dose;experimental study;Gene Expression;Genes;Genetic;Genetic Transcription;Glioblastoma;Glioma;Guanosine Triphosphate;Human;Hypoxia;Impairment;improved;improved outcome;inhibitor;Ligand Binding;Ligands;Maintenance;Malignant Breast Neoplasm;Malignant neoplasm of brain;Malignant neoplasm of prostate;Malignant Neoplasms;Modeling;Molecular;Monomeric GTP-Binding Proteins;mouse model;neuronal guidance;Normal tissue morphology;novel;novel therapeutic intervention;NRP1 gene;Nuclear;Nuclear Translocation;overexpression;Pathway interactions;Patient-Focused Outcomes;pharmacologic;Phosphotransferases;preclinical study;Primary Brain Neoplasms;programs;PTK2B gene;receptor;receptor binding;Recurrent disease;Regulation;Resistance;resistance mechanism;Role;self-renewal;Semaphorins;Signal Transduction;stem-like cell;Therapeutic;therapeutic target;therapy resistant;Toxic effect;tumor;tumor initiation;tumor progression;Tumor Promotion;tumorigenic;Tumorigenicity;WNT Signaling Pathway;Work;Xenograft Model

PROJECT_TITLE: Sema3C Signaling as an Alternative Activator of Canonical Wnt Signaling in Glioblastoma

STUDY_SECTION: MCTB

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics B Study Section[MCTB]


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Neurosciences;Rare Diseases

ORG_CITY: DETROIT

ORG_NAME: HENRY FORD HEALTH SYSTEM

ORG_STATE: MI

PHR: PROJECT NARRATIVE Malignant gliomas, which include glioblastoma, account for 46.6% of primary (de novo) brain tumors that often progress or recur as a more aggressive phenotype and are nearly uniformly fatal. Currently, the monitoring of recurrence and progression is performed by imaging which is limited by its sensitivity, dependent on the tumor size-threshold, the lack of specific criteria to diagnose and/or differentiate glioma from other conditions (e.g. CNS lymphoma, pseudoprogression or radiation necrosis), and availability and feasibility for some patients. This study proposes to establish a non-invasive approach using DNA methylation to improve detection and surveillance of glioma, with the ultimate goal of fine-tuning treatment by providing insight into the evolving tumor biology in real time.

PI_NAMEs: NOUSHMEHR, HOUTAN  (contact)

PROGRAM_OFFICER_NAME: GANGULY, ANIRUDDHA

PROJECT_TERMS: accurate diagnosis;Address;Aftercare;aggressive therapy;biomarker identification;Biopsy;Blood;Blood Tests;Brain Neoplasms;cell free DNA;Central Nervous System Lymphoma;Cerebrospinal Fluid;chromatin modification;Chromosome Deletion;Classification;Clinical;Clinical Management;Clinical Trials;clinically relevant;cohort;Complement;contrast enhanced;Coupled;CpG Island Methylator Phenotype;Data;Detection;Diagnosis;diagnostic biomarker;Disease;disease diagnosis;Disease Progression;DNA;DNA Markers;DNA Methylation;epigenetic marker;Epigenetic Process;epigenome;epigenomics;Evaluation;Evolution;Excision;FGFR3 gene;follow-up;Freezing;Gene Mutation;Genetic;Genomics;Glioblastoma;Glioma;Goals;high risk;Histology;Human;human data;Image;imaging biomarker;improved;Individual;Inflammatory;insight;Interdisciplinary Study;Intervention;Intracranial Neoplasms;Knowledge;liquid biopsy;Magnetic Resonance Imaging;Malignant - descriptor;Malignant Glioma;Malignant Neoplasms;Mediating;metabolic imaging;methylome;minimally invasive;Molecular;Molecular Analysis;molecular dynamics;Molecular Evolution;molecular subtypes;Molecular Target;Monitor;Monitoring for Recurrence;Mutation;Necrosis Induction;Neoplasm Circulating Cells;Neurofibromatosis 1;NF1 gene;NF1 mutation;novel strategies;Operative Surgical Procedures;Outcome;patient stratification;Patients;Pattern;perfusion imaging;Phenotype;Plasma;Plasma Cells;Postoperative Period;Procedures;prognostic;prognostic assays;prospective;Prospective cohort;Protocols documentation;Publishing;quantitative imaging;Radiation necrosis;Records;Recurrence;Recurrence Score;Regimen;Reporting;Resolution;Risk;Role;serial imaging;Serum;Somatic Mutation;Specimen;standard of care;Subgroup;System;TACC3 gene;Techniques;Testing;Time;Tissues;tool;treatment response;tumor;Tumor Biology;Tumor Burden;tumor DNA;tumor molecular fingerprint;tumor progression;Tumor Tissue;Variant;Visual;Work

PROJECT_TITLE: Circulating cell-free DNA methylation as an accurate tool for detection and clinical follow-up of glioma

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


ADMINISTERING_IC: DK

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: La Jolla

ORG_NAME: SALK INSTITUTE FOR BIOLOGICAL STUDIES

PHR: Project Narrative There exists a knowledge gap in obesity and adipocyte biology, as there are still no effective anti-obesity drugs or treatments. Recent identification of previously unannotated microproteins in human and mouse genomes has been made possible by breakthroughs in genomic and proteomic technologies. By applying these new methods on adipocytes, this study will characterize adipocyte microproteins that affect adipogenesis and insulin signaling.

PI_NAMEs: PAI, VICTOR JIEH PONG (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: 3T3-L1 Cells;Address;adipocyte biology;adipocyte differentiation;Adipocytes;Adipose tissue;Adult;Affect;Alanine;Algorithms;Anti-Obesity Agents;Antibodies;Biological;Biology;Blood Glucose;Body Weight;Body Weight decreased;candidate validation;Cell Line;Cells;Code;Codon Nucleotides;cohort;Computational algorithm;CRISPR library;CRISPR screen;CRISPR/Cas technology;Data;Databases;diverse data;DNA sequencing;Drug Targeting;effective therapy;Energy Intake;Epidemic;experience;experimental study;Fatty acid glycerol esters;Fatty Liver;FDA approved;Generations;Genes;Genetic;Genetic Variation;Genome;Genomics;glucose uptake;Goals;Homeostasis;Human Genome;Hypertrophy;Immunofluorescence Immunologic;Immunoprecipitation;in vitro Model;Individual;Inflammation;Insulin Resistance;insulin signaling;interest;Knock-out;Knowledge;Laboratories;lipid biosynthesis;live cell imaging;Liver;Location;Mass Spectrum Analysis;Metabolic Diseases;Methods;Molecular Biology;Monitor;mouse genome;mouse model;Mouse Strains;multiple omics;Mus;Mutagenesis;new therapeutic target;next generation;Non-Insulin-Dependent Diabetes Mellitus;Nonesterified Fatty Acids;novel;Obesity;obesity treatment;Open Reading Frames;Output;overexpression;Overweight;Pathogenesis;Pathway interactions;Patients;Peptides;Phenotype;Phosphorylation;Physiological;Physiology;Play;protein protein interaction;Proteins;Proteomics;Publishing;Retinal blind spot;ribosome profiling;Role;Scanning;Scientist;Serine;Signal Transduction;Technology;Testing;transcriptome sequencing;Translating;Triglycerides;Validation;Work

PROJECT_TITLE: Trimming the fat with small proteins: Micropeptides in adipogenesis


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_CITY: CHICAGO

ORG_DEPT: NEUROLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: The continued generation of new neurons in a region of the brain known as the hippocampus is involved in regulating various types of cognitive behavior. We have found that noggin, a molecule that modulates a specific signaling system in the brain, regulates neurogenesis and behavior. The proposed studies seek to understand how noggin works in the brain with a long- term goal of defining specific targets for drug treatment that may help to maintain normal cognitive function.

PI_NAMEs: KESSLER, JOHN A (contact)

PROGRAM_OFFICER_NAME: LAVAUTE, TIMOTHY M

PROJECT_TERMS: Adult;Affective;anti-depressive agents;Attenuated;Behavior;Behavioral;Brain;Brain region;Cilia;Coculture Techniques;Cognition;Cognitive;cognitive enhancement;cognitive function;cognitive performance;cognitive task;Complex;conditional knockout;Cytoplasmic Granules;dentate gyrus;designer receptors exclusively activated by designer drugs;Environment;environmental enrichment for laboratory animals;Enzyme-Linked Immunosorbent Assay;Exercise;experience;Exposure to;Gene Expression;Generations;Goals;Hippocampus;in vivo;Inbred Mouse;Induced Neurons;Infusion procedures;inhibitor;knock-down;Knock-out;Link;Maps;Mediating;Membrane;Mus;nerve stem cell;neurogenesis;Neurons;Newborn Infant;overexpression;Performance;Plasma;plasmonics;Play;Proliferating;Property;Proteins;rabies viral tracing;Regulation;response;Role;Running;sensor;SHH gene;Signal Pathway;Signal Transduction;smoothened signaling pathway;stem cell proliferation;stem cells;Stimulus;Structure;Surface;Synapses;System;targeted treatment;Testing;Transgenic Organisms;Ventricular;Viral;Work

PROJECT_TITLE: Regulation of Hippocampal Neurogenesis and Behavior by Noggin

STUDY_SECTION: NCF

STUDY_SECTION_NAME: Neurogenesis and Cell Fate Study Section[NCF]


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Bioengineering;Chronic Pain;Genetics;Lung;Nanotechnology;Neurosciences;Pain Research;Sleep Research

ORG_CITY: SAN ANTONIO

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

ORG_STATE: TX

PHR: PROJECT NARRATIVE  The proposed research is relevant to public health because millions of Americans suffer from sleep disturbances that contribute to persistent pain. The mechanisms underlying this contribution are largely unknown and require rigorous, multidisciplinary studies to increase our scientific knowledge of this clinical problem. The project is relevant to NIH's mission because identifying mechanisms that that link the comorbidity of sleep disturbances and persistent pain may result in new complimentary treatment paradigms that improve patient quality of life.

PI_NAMEs: JESKE, NATHANIEL AARON (contact);KIM, YU SHIN ;TONEY, GLENN M

PROGRAM_OFFICER_NAME: GREENWELL, THOMAS

PROJECT_TERMS: Abate;Affect;Afferent Neurons;American;Anti-Inflammatory Agents;Behavior;Behavioral;Biochemical;Biological Assay;Cell Separation;Chronic;chronic pain;chronic painful condition;Clinical;clinical diagnosis;Clinical Research;comorbidity;Complement;Continuous Positive Airway Pressure;Coupled;Cre lox recombination system;cytokine;Development;Diagnosis;Disease;DNA Binding;experience;Future;Gene Modified;Genetic Screening;Goals;Health;health determinants;Human;Hypoxia;hypoxia inducible factor 1;Image;Immune;improved;In Vitro;in vivo;in vivo imaging;inducible Cre;Infiltration;Inflammatory;innovation;interdisciplinary approach;Knowledge;Link;Location;Macrophage;Maintenance;Measures;Mission;Modeling;Molecular;Molecular Genetics;molecular marker;multidisciplinary;Mus;nanoGold;nanoparticle drug;Neuroimmune;Neuronal Plasticity;Neurons;Nociception;Nociceptors;nocturnal Hypoxemia;novel;Obstructive Sleep Apnea;Oxidative Stress;Pain;pain behavior;pain chronification;pain sensation;Pathogenicity;Patients;Peripheral;Persistent pain;Personal Satisfaction;pharmacologic;Pharmacology Study;Pharmacotherapy;Phase;Phenotype;Physiological;Pilot Projects;Population;preclinical study;Production;Protocols documentation;Public Health;Quality of life;Recurrence;Reporting;Research;RNA;Rodent;Rodent Model;Role;Signal Pathway;Sleep;Sleep Disorders;Sleep disturbances;System;Testing;Time;Tissues;Transcript;Transgenic Organisms;Translating;trend;United States National Institutes of Health;Up-Regulation;Work

PROJECT_TITLE: Chronic Intermittent Hypoxia and Hyperalgesic Priming

STUDY_SECTION: NPI

STUDY_SECTION_NAME: Neurobiology of Pain and Itch Study Section [NPI]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Electronic Nicotine Delivery Systems;Pediatric;Prevention;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: Los Angeles

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: PROJECT NARRATIVE This study seeks to develop and test an intervention designed to reduce vaping behaviors and the likelihood of future combustible cigarette smoking onset among young adults. The study provides support for a very brief, inexpensive, single-session, and mobile phone-based intervention that can reach a wide range of diverse and vulnerable youth populations who may not otherwise seek vaping cessation services. By developing and testing an intervention that reduces vaping and the likelihood of smoking onset, the study also has the potential to reduce the burden of both smoking and vaping long-term effects, including addiction, pulmonary and cardiovascular disease, and cancer.

PI_NAMEs: TRAN, DENISE DAO (contact)

PROGRAM_OFFICER_NAME: LAO, GUIFANG

PROJECT_TERMS: acceptability and feasibility;addiction;Address;Adolescent;advanced analytics;Affect;Age;age group;Alcohol consumption;Area;Behavior;behavior change;Belief;brief intervention;Cardiovascular Diseases;Cardiovascular system;Cellular Phone;Chemicals;Cigarette;cigarette smoke;cigarette smoking;Clinical;Cognition;Cognitive;cohort;combustible cigarette;combustible tobacco;comparison control;Curiosities;Data;design;Development;digital;Early Intervention;Education;Educational Curriculum;effectiveness evaluation;efficacy evaluation;efficacy testing;Electronic cigarette;electronic cigarette use;electronic cigarette user;Ethnic Origin;Evaluation;evidence base;Feedback;follow-up;Frequencies;Future;Grant;Growth;Health;Individual;interest;Internet;Intervention;intervention effect;Interview;Link;Long-Term Effects;Longitudinal cohort;Longitudinal Studies;Lung Diseases;Malignant Neoplasms;Manuscripts;meetings;Mentors;Mentorship;Methodology;mobile phone based intervention;Motivation;motivational enhancement therapy;multidisciplinary;never smoking;Nicotine;Nicotine Dependence;normative feedback;online intervention;Outcome;peer;Perception;Personal Satisfaction;personalized normative feedback;Pilot Projects;pilot test;Play;Policies;Population;Populations at Risk;Predisposition;Prevalence;prevent;preventive intervention;Procedures;programs;Proliferating;Public Health;Publishing;Race;Randomized;Randomized, Controlled Trials;recruit;Reporting;Research;Research Design;Research Personnel;Resistance;respiratory;risk mitigation;Risk Reduction;screening;Self Efficacy;Services;sex;skills;Smoke;Smoking;smoking addiction;Smoking Behavior;smoking initiation;smoking prevalence;social;social norm;substance use;Surveys;Target Populations;Techniques;Technology;Testing;Text Messaging;theories;therapy design;therapy development;Time;Tobacco;Tobacco use;Training;Treatment Efficacy;vaper;vaping;web-based intervention;women versus men;Work;Writing;young adult;Youth

PROJECT_TITLE: Development of an online, theory-based intervention to reduce e-cigarette use and susceptibility to smoking in young adults: A pilot study

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


ORG_CITY: LA JOLLA

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative  Alpha cells are one of the primary endocrine cells in pancreatic islets. This project will investigate the regulatory effects of α-cells on maternal metabolic adaptation.

PI_NAMEs: SHAO, JIANHUA  (contact)

PROGRAM_OFFICER_NAME: BROCKWAY, HEATHER MARIE

PROJECT_TERMS: Ablation;Address;Adult;Agonist;Alpha Cell;Amino Acids;antagonist;Attenuated;Beta Cell;Binding;Blood;Blood Glucose;Cell Proliferation;Cells;Compensation;Data;Endocrine;Failure;Fasting;Fc Receptor;fetal;Foundations;Future;GCG gene;Gene Expression Profile;Genes;genetic approach;Gestational Diabetes;Glucagon;Glucagon Receptor;glucagon-like peptide 1;Glucose;glucose metabolism;glucose tolerance;Health;Hormones;Human;Impairment;improved;Injections;Insulin;Insulin Resistance;insulin secretion;islet;Islets of Langerhans;Knock-out;knockout gene;Knockout Mice;Knowledge;Lactation;Left;lipid metabolism;Mediating;Metabolic;Metabolic stress;Metabolism;mouse model;Mus;Nutrient;offspring;Pancreas;paracrine;Pathway interactions;Placental Lactogen;Play;Pregnancy;Pregnancy Outcome;pregnant;preproglucagons;Production;proglucagon;programs;Prolactin Receptor;Proprotein Convertase 2;Proteins;Rattus;receptor;Receptor Signaling;reconstitution;Reporting;Reproductive Medicine;Research;Role;Series;Signal Transduction;single-cell RNA sequencing;Sorting;Structure of alpha Cell of islet;success;transcriptome sequencing

PROJECT_TITLE: Pancreatic alpha-cells and Maternal metabolic Adaptation

STUDY_SECTION: BMDM

STUDY_SECTION_NAME: Basic Mechanisms of Diabetes and Metabolism Study Section[BMDM]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Breast Cancer;Cancer;Immunotherapy;Nanotechnology;Women's Health Research

ORG_CITY: SEATTLE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative  Metastatic triple negative breast cancer is a devastating disease where the best chemotherapeutics, immunotherapeutic and their combinations still yield limited life-extension outcomes. Leveraging on the benefits of chemo/immuno therapeutics and an innovative targeted drug combination nanoparticle strategy, this project aims to co-deliver drugs into metastatic cancer cells for enhanced chemotherapy and immune checkpoint inhibitor therapy.

PI_NAMEs: MU, QINGXIN  (contact)

PROGRAM_OFFICER_NAME: FU, YALI

PROJECT_TERMS: Animal Model;anti-PD-L1 therapy;anti-PD1 antibodies;Antibody-drug conjugates;Antimetabolites;Behavior;Binding;Biological Markers;Breast Cancer Cell;Breast Cancer Model;Breast Cancer Treatment;cancer cell;cancer immunotherapy;Cause of Death;Cell Surface Receptors;Cells;cellular targeting;checkpoint therapy;chemotherapy;Clinic;Clinical;clinical translation;Combination Drug Therapy;Combined Modality Therapy;Development;Disease;Disseminated Malignant Neoplasm;Distant;dosage;Dose;Drug Combinations;Drug Compounding;Drug Delivery Systems;Drug Kinetics;Drug Synergism;Drug Targeting;Eligibility Determination;Endoglin;ENG gene;Formulation;Future;gemcitabine;Goals;Guidelines;Half-Life;Human;Image;Immune checkpoint inhibitor;Immunocompetent;immunoregulation;Immunotherapeutic agent;Immunotherapy;improved;improved outcome;In Vitro;in vivo;indexing;innovation;insight;Intercellular adhesion molecule 1;Life Extension;Ligands;lipid nanoparticle;Lipids;Lung;Malignant Breast Neoplasm;Membrane Glycoproteins;Messenger RNA;Metastatic breast cancer;Metastatic Neoplasm to the Lung;Micrometastasis;Modeling;Monitor;mortality;Mus;Myeloid-derived suppressor cells;nanoformulation;nanoparticle;Neoplasm Metastasis;New Agents;novel drug combination;novel therapeutics;Outcome;Paclitaxel;Patients;PD-1/PD-L1;PDL1 inhibitors;pembrolizumab;peptide drug;Peptides;Pharmaceutical Preparations;Plasma;Population;Primary Neoplasm;Prognosis;programmed cell death ligand 1;Property;Publishing;receptor;receptor expression;Regimen;Reporting;response;Site;Spleen;Survival Rate;synergism;systemic toxicity;targeted treatment;taxane;Technology;Testing;Therapeutic;therapeutic target;therapy outcome;Time;Tissues;Toxic effect;treatment effect;Treatment Efficacy;Treatment outcome;triple-negative invasive breast carcinoma;tumor;tumor growth;Up-Regulation;uptake;Women's mortality;Work

PROJECT_TITLE: Drug combination nanoparticles for advanced treatment of metastatic TNBC


NIH_SPENDING_CATS: Breastfeeding, Lactation and Breast Milk;Clinical Research;Clinical Trials and Supportive Activities;Conditions Affecting the Embryonic and Fetal Periods;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Women's Health Research

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: In anticipation of this application to become a clinical center with the MFMU Network, we have spent the last decade cultivating a culture amongst our academic Maternal-Fetal Medicine (MFM) team of 38 physicians which encourages clinical research as part and parcel to reducing maternal and neonatal morbidity and mortality. In addition to far exceeding the requisite diversity and number of patients with “high risk” conditions our vibrant and cohesive large academic MFM Division cares for, we have gained MFM clinical trials experience with a well-versed and high performance 24/7 research staff, and developed several unique special strengths to enrich the impact and science of the MFMU. Our dedication to bringing care and research to all pregnant and lactating people and their infants in greater Houston will enable us to meet and exceed the stated goals of the NICHD for RFA-HD-23-016.

PI_NAMEs: BELFORT, MICHAEL A;EPPES, CATHERINE SQUIRE (contact)

PROJECT_TERMS: Affect;Caring;Certification;Child;Clinical;clinical care;clinical center;Clinical Protocols;Clinical Research;clinical research site;Clinical Trials;Clinical Trials Unit;Collaborations;college;Dedications;Discipline of obstetrics;Elements;Eligibility Determination;Enrollment;experience;follow-up;Funding;Goals;high risk;improved;Infant;innovation;Institution;Lactation;Leadership;Letters;Longterm Follow-up;maternal morbidity;Maternal-fetal medicine;Maternal-Fetal Medicine Units Network;Medical center;Medicine;member;Mission;mortality;Multi-Institutional Clinical Trial;National Institute of Child Health and Human Development;Neonatal;Neonatal Intensive Care;neonatal morbidity;obstetric care;Outcome;Participant;Patients;Performance;Perinatal;perinatal medicine;Persons;Physicians;Population;Pregnancy;pregnancy health;pregnant;Prenatal care;Productivity;recruit;Research;Research Infrastructure;research study;Resources;Rewards;Risk;Science;Science Enrichment;Scientific Advances and Accomplishments;Scientist;Site;success;Texas;Time;translational impact;Translational Research;Translations;trial design;United States;United States National Institutes of Health;Vision;Vulnerable Populations;Work

PROJECT_TITLE: Baylor College of Medicine & Texas Children's Clinical Center for Research in the NICHD Maternal-Fetal Medicine Units (MFMU) Network


NIH_SPENDING_CATS: Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Drug Abuse (NIDA only);Electronic Nicotine Delivery Systems;Neurosciences;Substance Misuse;Tobacco

PHR: Narrative We will use an innovative approach allowing identification of activated neurons at single-cell resolution throughout the entire brain to identify the whole-brain functional networks that are associated with four fundamental phases in the development of tobacco use disorder: acute nicotine, chronic dependence, acute withdrawal, and protracted abstinence. The overarching hypothesis is that coordinated activation of long-range cholinergic neurons is associated with decreased whole-brain modularity and withdrawal-related behaviors that can be partially normalized using FDA-approved medications. This project will identify the networks activated during critical phases relevant to tobacco use disorder and electronic cigarette use and identify the mechanism at the network level that underlies the effect of FDA-approved medications.

PI_NAMEs: GEORGE, OLIVIER  (contact)

PROGRAM_OFFICER_NAME: BERTON, OLIVIER

PROJECT_TERMS: Abstinence;Acute;addiction;Address;Affect;Animals;Architecture;associated symptom;Behavior;Behavior Therapy;Behavioral;behavioral response;Biological Markers;Biomedical Engineering;Brain;Brain imaging;Brain region;Bupropion;Calcium;Cells;cholinergic neuron;Chronic;combinatorial;connectome;Data;Dependence;Development;electronic cigarette use;FDA approved;field study;Fingerprint;Gene Expression;Genetic study;Goals;heuristics;Image;Immediate-Early Genes;Individual;Individual Differences;innovation;Intoxication;Knowledge;Label;Light;Maps;Measures;Mediating;microscopic imaging;Microscopy;Modeling;molecular phenotype;Mus;neural network;Neurons;Nicotine;Nicotine Dependence;nicotine exposure;nicotine replacement;nicotine treatment;nicotine use;nicotine vapor;Nicotine Withdrawal;Nicotinic Receptors;optogenetics;Outcome;Pathway Analysis;Pathway interactions;Pattern;Pharmaceutical Preparations;Pharmacological Treatment;Phase;Phenotype;Physiological;Process;Protocols documentation;recruit;Relapse;Reporter;Resolution;Role;Self Administration;Sex Differences;Testing;theories;Therapeutic Effect;Time;Tobacco Use Disorder;Transgenic Animals;Transgenic Mice;varenicline;Viral Vector;Withdrawal

PROJECT_TITLE: Single-cell whole brain imaging of nicotine intoxication, dependence, and abstinence


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Clinical Research;Precision Medicine

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE. Mitochondrial respiratory chain (RC) disease is a highly heterogeneous, multi- systemic genetic disorder affecting all organs and ages. Translational RC disease investigations in human cell and simple animal models may identify effective therapies, and specific mechanisms, to improve overall health.

PI_NAMEs: FALK, MARNI J (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TERMS: Acute;Affect;Age;Animal Model;Area;Basic Science;Biochemical;Biochemical Pathway;Caenorhabditis elegans;Cell model;Cells;Clinical;Clinical Trials;cofactor;Collection;detection of nutrient;Disease;disease model;disorder subtype;Down's Syndrome;Educational process of instructing;effective therapy;Etiology;FDA approved;Fibroblasts;Functional disorder;Genes;Genetic Diseases;Genome;glycosylation;Health;high-throughput drug screening;Human;improved;in vivo;insight;International;Invertebrates;Investigation;Lead;Macronutrients Nutrition;Medicine;Methodology;Mitochondria;Mitochondrial Proteins;Modeling;Molecular;nanosensors;National Institute of General Medical Sciences;novel;novel therapeutics;Nuclear;Nutritional Support;Organ;Pathogenicity;Patients;Phenotype;Post-Translational Protein Processing;pre-clinical;precision medicine;Precision therapeutics;Productivity;programs;proteotoxicity;Research;Research Personnel;Respiratory Chain;Signal Transduction;Stress;System;Therapeutic;therapeutic candidate;therapeutic target;translational research program;Validation;Variant;Vitamins;Zebrafish

PROJECT_TITLE: Mitochondrial respiratory chain disease mechanistic and therapeutic modeling

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Genetics

ORG_DEPT: BIOLOGY

PHR: An epithelial-mesenchymal transition (EMT) occurs in almost all animals, moving cells that originate in an epithelium to produce the connective tissue of the embryo. In embryos this process must be completed, and in carcinomas the EMT process is co-opted and must be stopped. Thus, in order to prevent birth defects, and to stop metastatic events it is crucial to understand how the EMT works, which is the goal of this project.

PI_NAMEs: MCCLAY, DAVID  (contact)

PROGRAM_OFFICER_NAME: MUKHOPADHYAY, MAHUA

PROJECT_TERMS: Actins;Adhesions;Animals;Basal lamina;Basement membrane;Biological Assay;Biological Models;candidate identification;Carcinoma;Cell Lineage;Cell Physiology;Cell Polarity;cell type;Cells;Chick;Chromosomes;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;Congenital Abnormality;Databases;differential expression;Disease;Dissection;Drosophila genus;Embryo;embryo cell;Embryonic Connective Tissue;Endocytosis;Epithelial Cells;epithelial to mesenchymal transition;Epithelium;Event;Exocytosis;experimental study;Failure;Fertilization;Foundations;Funding;Genes;Genome;genomic tools;Goals;Human;in vivo;in vivo Model;interest;Invaded;Investigation;Knowledge;Lead;Learning;Length;Light;Longitudinal Studies;Malignant Neoplasms;Membrane;Mesenchymal;Mesoderm Cell;metastatic process;Modeling;Molecular;molecular modeling;mosaic;Motility;Movement;Mus;Myosin ATPase;Neoplasm Metastasis;Neural Crest;Pathway interactions;Phenotype;Pigments;Play;prevent;Process;programs;Research;Role;Sea Urchins;Signal Transduction;single-cell RNA sequencing;small hairpin RNA;Snails;Specificity;System;Testing;Time;Tissues;tool;transcription factor;transcriptome sequencing;tumor;Validation;Work;Zebrafish

PROJECT_TITLE: Embryonic Cell Recognition: Specificity Determinants

STUDY_SECTION_NAME: Development - 2 Study Section[DEV2]


NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Clinical Research;Congenital Heart Disease;Congenital Structural Anomalies;Dissemination and Implementation Research;Health Services;Heart Disease;Infant Mortality;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Rare Diseases

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: PROJECT NARRATIVE  Congenital heart disease is the most common birth defect and can be missed during pregnancy scan and newborn exam leading to delayed detection, poor outcomes, and death. This application seeks to test and develop a critical congenital heart disease screening machine learning algorithm that combines the current screening standard, oxygen saturation, with additional features to assess blood flow and perfusion and incorporates dynamic data from both inpatient and outpatient settings. This approach has the potential to increase infant survival and will develop neonatal specific devices using artificial intelligence driven diagnostics, which are priorities to the NICHD Pregnancy and Perinatology Branch and Obstetric and Pediatric Pharmacology and Therapeutics Branch.

PI_NAMEs: SIEFKES, HEATHER M (contact)

PROGRAM_OFFICER_NAME: PARISI, MELISSA

PROJECT_TERMS: Affect;Age;algorithmic bias;Algorithms;Aortic coarctation;Artificial Intelligence;Blood flow;blood perfusion;career;Cessation of life;Characteristics;Classification;Clinical;Cluster randomized trial;cohort;Congenital Abnormality;congenital heart abnormality;Congenital Heart Defects;Critical Congenital Heart Defects;critical congenital heart disease;Data;Defect;Detection;Device or Instrument Development;Devices;Diagnosis;Diagnostic;Ductus Arteriosus;efficacy evaluation;follow-up;foot;Hand;heart disease risk;Heart Rate;Hospitalization;Hospitals;Hour;Hypoxemia;implementation evaluation;implementation process;implementation science;improved;indexing;Infant;innovation;Inpatients;Intervention;Knowledge;Label;Leadership;Machine Learning;machine learning algorithm;machine learning classifier;machine learning model;Measurement;Measures;Modeling;Morbidity - disease rate;Morphologic artifacts;mortality;National Institute of Child Health and Human Development;Neonatal;neonatal period;Neonatal Screening;Newborn Infant;Non-Invasive Detection;Nurseries;Obstetric pharmacology;Obstruction;Outcome;outcome prediction;Outpatients;Output;Oxygen;Patients;pediatric pharmacology;Perfusion;Perinatal;Perinatology;point of care;Pregnancy;preservation;prognostication;Prospective cohort;Pulse Oximetry;Randomized;Regression Analysis;Regulation;Rest;routine screening;Scanning;screening;Series;Site;skills;Specificity;Techniques;tertiary care;Testing;Therapeutic;Time;Training;United States;Voting;Work

PROJECT_TITLE: Machine Learning for CCHD Screening using Dynamic Data

STUDY_SECTION_NAME: Obstetrics and Maternal-Fetal Biology Study Section[CHHD-B]


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Dissemination and Implementation Research;HIV/AIDS;Prevention

ORG_CITY: BALTIMORE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: PROJECT NARRATIVE To reach HIV epidemic control, Zambia needs to develop local implementation science capacity to create innovative ways to reach key and vulnerable populations with HIV service delivery. To train this cadre of implementation scientists, we propose the Zambia Education Network for Implementation Science Training in Health (ZENITH), a partnership between Zambia's University Teaching Hospital (UTH) and the University of Maryland Baltimore (UMB) that focuses on building implementation science (IS) capacity at UTH. ZENITH will build IS capacity through 1. an Implementation Science Institute at UTH (short-term training); 2. an online MHS in Implementation and Dissemination Science at UMB (medium term); and 3. PhD at UMB (long term); all coupled with twinned senior and junior mentors and a monthly research ECHO seminar.

PI_NAMEs: CLAASSEN, CASSIDY W. (contact);MULENGA, LLOYD BERDARD

PROGRAM_OFFICER_NAME: BANSAL, GEETHA PARTHASARATHY

PROJECT_TERMS: Address;Adult;Baltimore;Biometry;Clinical;dissemination science;Doctor of Philosophy;doctoral student;Education;Educational process of instructing;Epidemic;epidemic response;Epidemiology;experience;Goals;graduate school;Grant;Health;Health Sciences;HIV;implementation science;Journals;Learning;Manuscripts;Maryland;Medical;meetings;Mentors;Mentorship;Methods;Modeling;Prevalence;Qualitative Methods;Research;Scientist;Site;Social Sciences;Students;Teaching Hospitals;Training;Twin Multiple Birth;Universities;virtual;Vulnerable Populations;Writing;Zambia

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DCAI-D(56)]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Prevention;Rare Diseases;Vector-Borne Diseases

ORG_CITY: LIMA

ORG_COUNTRY: PERU

ORG_FIPS: PE

ORG_NAME: UNIVERSIDAD PERUANA CAYETANO HEREDIA

PHR: Program Director/Principal Investigator (Last, First, Middle): LESCANO, Andres G. Emerging infections continue to be primary concerns in Peru, South America and the world. Zika erupted in the Americas after quietly circulating in Brazil for nearly two years with a catastrophic and yet unexplained impact on microcephaly and the overall Zika congenital syndrome. The Peruvian north coast of Peru recently suffered its largest dengue outbreak on record after the 2017 Coastal El Niño event appeared without warning, leading to nearly 70,000 cases and 89 recorded deaths. Antimicrobial resistance continues to advance worldwide despite major efforts to promote the rational use of antibiotics while Chapare arenavirus re-emerged in neighboring Bolivia just a few weeks ago. Early detection and effective response to future outbreaks of emerging diseases will required better-trained epidemiologists, in larger numbers, and present in high-risk areas. OMB No. 0925-0001/0002 (Rev. 01/18 Approved Through 03/31/2020) Page Continuation Format Page

PI_NAMEs: LESCANO, ANDRES G (contact)

PROGRAM_OFFICER_NAME: SINA, BARBARA J

PROJECT_TERMS: Address;Affect;Antimicrobial Resistance;Area;Brazil;career;Cessation of life;cohort;cost effective;Decentralization;Dengue;Disease;Disease Outbreaks;Doctor of Philosophy;Early Diagnosis;Educational Curriculum;Environment;epidemic potential;Epidemiologist;Epidemiology;epidemiology study;Event;exhaust;experience;Funding;Future;Goals;Grant;Health Personnel;high risk;improved;innovation;Institution;Internships;Malaria;Manuscripts;Measles;Mentors;migration;Modeling;Outcome;Outcomes Research;Paper;Peru;Peruvian;Prevention;Principal Investigator;Productivity;programs;Public Health;Public Sector;Publishing;Research;Research Training;Respiratory Tract Infections;response;Scientist;Secure;Site;Source;South America;Students;Syndrome;Training;training opportunity;United States National Institutes of Health;Universities;Vaccines;Venezuelan;Volatilization;Yellow Fever;ZIKA;Zoonoses

PROJECT_TITLE: Emerge: Emerging Diseases Epidemiology Research Training

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDM-Z(55)R]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Cancer Genomics;Genetics;Human Genome;Women's Health Research

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE ER+/HER2+ breast cancer comprises ∼13% of all breast cancer, with intensive crosstalk between ER and HER2 signaling. Various combinations of endocrine and anti-HER2 targeted agents are under clinical evaluation, yet only a partial response has been achieved. This proposal seeks to identify mechanisms of ER/HER2 crosstalk at the single-cell level that accounts for the partial response of ER+/HER2+ patients to dual ER/HER2 blockade.

PI_NAMEs: XU, WEI  (contact)

PROGRAM_OFFICER_NAME: GREENBERG, WILLIAM A

PROJECT_TERMS: Ablation;Aftercare;ATAC-seq;Biologic Characteristic;Bromodomain;BT 474;Cell Line;Cells;Chromatin;Cleavage Under Targets and Release Using Nuclease;Clinical;Compensation;Complex;Data;Development;digital;Endocrine;Epigenetic Process;ERBB2 gene;Estrogen Antagonists;Estrogen Receptors;Foundations;Fulvestrant;Genes;genome-wide;Growth;Heterogeneity;histone acetyltransferase;Hormone Receptor;hormone receptor-positive;hormone sensitivity;hormone therapy;Human;Immunofluorescence Immunologic;Impairment;improved;in vitro Model;in vivo;inhibitor;insight;Investigation;knock-down;Knock-out;lapatinib;Lead;Link;loss of function;Malignant Breast Neoplasm;Mammary Neoplasms;MAP Kinase Gene;Measures;Mediating;Modeling;Molecular;novel;Organoids;partial response;Pathway interactions;patient subsets;Patient-Focused Outcomes;Patients;personalized medicine;Phenotype;Phosphorylation;Pre-Clinical Model;Progesterone Receptors;Prognosis;Proteins;Proto-Oncogene Proteins c-akt;Receptor Activation;Receptor Signaling;Regimen;research clinical testing;Resistance;resistance mechanism;response;Role;Signal Pathway;Signal Transduction;single nucleus RNA-sequencing;single-cell RNA sequencing;Specimen;success;targeted agent;targeted treatment;Testing;The Cancer Genome Atlas;transcription factor;transcriptome;Trastuzumab;Treatment Protocols;treatment response;tumor;tumor growth;tumor xenograft;Variant;Xenograft procedure

PROJECT_TITLE: Functions of BRD8 in HR+/HER2+ breast cancer


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Clinical Research;Coronaviruses;Emerging Infectious Diseases;Genetics;HIV/AIDS;Human Genome;Infectious Diseases

ORG_CITY: BOSTON

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

ORG_STATE: MA

PHR: PROJECT NARRATIVE The Botswana-Harvard AIDS Institute Partnership (BHP), a partnership between the Harvard TH Chan School of Public Health and the Ministry of Health in Botswana, is the site of a mature training program in HIV genomic, treatment, and cure research. BHP has become the leading site for modern laboratory and epidemiologic training in HIV in the region, with an ongoing mission to train the next generation of scientific leaders in Botswana.

PI_NAMEs: LOCKMAN, SHAHIN ;MAKHEMA, JOSEPH MOEKETSI;SHAPIRO, ROGER L (contact)

PROJECT_TERMS: 2019-nCoV;Acquired Immunodeficiency Syndrome;Adult;Advisory Committees;Africa;African;Anti-Retroviral Agents;Area;Botswana;Clinical;Clinical Trials;Doctor of Philosophy;Environment;Epidemic;experience;Faculty;faculty mentor;Funding;Genomics;Goals;Health;High Prevalence;HIV;HIV/AIDS;Infrastructure;International;Journals;Laboratories;Laboratory Research;Mentors;Monitor;Patients;Performance;Pharmacotherapy;Physicians;Positioning Attribute;Postdoctoral Fellow;pre-doctoral;programs;Public Health Schools;Publications;Research;Research Activity;Research Design;Research Personnel;Research Training;Resistance;SARS-CoV-2 variant;Site;success;Teacher Professional Development;Techniques;Training;training opportunity;Training Programs;Training Support;treatment program;treatment research;Universities;Work

PROJECT_TITLE: Training in HIV Genomics, Treatment, and Cure Research in Botswana


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Aging;Arthritis;Bioengineering;Biomedical Imaging;Networking and Information Technology R&D (NITRD)

ORG_CITY: PROVIDENCE

ORG_NAME: RHODE ISLAND HOSPITAL

ORG_STATE: RI

PHR: Narrative Musculoskeletal disorders affect over 250 million people worldwide. The ability to accurately measure musculoskeletal kinematics is necessary to advance our understanding of normal joint function, the changes associated with musculoskeletal diseases, the effects of treatment, and results of treatment refinement. The aim of this proposal is to develop a state-of-the-art, open-source software program to simplify and improve image- based musculoskeletal analysis. The software we develop will broaden access to image-based kinematic analysis and provide a dynamic platform for the sharing of novel analysis algorithms, methodologies, and data, which will hasten translation to clinical implementation.

PI_NAMEs: CRISCO, JOSEPH J (contact)

PROGRAM_OFFICER_NAME: WANG, XIBIN

PROJECT_TERMS: 3-Dimensional;Adoption;Affect;Age;Aging;Agreement;Algorithmic Analysis;Algorithms;Ankle;anterior cruciate ligament reconstruction;Arthritis;base;Biomedical Engineering;bone;bone imaging;Bone structure;Cadaver;Clinic;Clinical;clinical implementation;clinical translation;Code;Collaborations;Communities;Complex;Computer software;Custom;Data;Data Set;Degenerative polyarthritis;Detection;Development Plans;Disease;Documentation;Ecosystem;Educational Models;Educational workshop;experience;Feedback;foot;Fostering;Freedom;Generations;Goals;graphical user interface;Hand;Image;image registration;image visualization;imaging modality;imaging program;imaging Segmentation;imaging software;Implant;improved;in vivo;Individual;Industry Standard;Infrastructure;Injury;innovation;interest;joint function;Joints;kinematics;Knee joint;Laboratories;Letters;Licensing;ligament injury;Magnetic Resonance Imaging;Maintenance;Measures;Medical Imaging;Methodology;Methods;Modeling;Motion;multimodality;multiple datasets;Musculoskeletal;Musculoskeletal Diseases;novel;open source;open source library;ORALIT;Osteoporosis;Output;Pathology;Persons;Pilot Projects;Population;Positioning Attribute;Process;programs;Public Domains;Publications;quality assurance;Replacement Arthroplasty;Research;research and development;Research Personnel;Research Project Grants;research study;Resource Sharing;response;Roentgen Rays;sharing platform;Shoulder;Site;skeletal;software development;Spinal cord injury;Surface;Surveys;System;Techniques;Technology;Testing;Thumb structure;tool development;Training;Training and Education;Translations;Trauma;treatment effect;Universities;Update;user-friendly;Vertebral column;Visualization;web site;Work;Wrist;Writing;X-Ray Computed Tomography

PROJECT_TITLE: Multi-modal Tracking of In Vivo Skeletal Structures and Implants

STUDY_SECTION: MRS

STUDY_SECTION_NAME: Musculoskeletal Rehabilitation Sciences Study Section[MRS]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Clinical Research;Dementia;Genetics;Lewy Body Dementia;Neurodegenerative;Neurosciences;Precision Medicine;Prevention

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: BROWN UNIVERSITY

PHR: Project Narrative: There are no biomarkers to identify individuals at increased risk of developing Alzheimer's Disease (AD) and Related Disorders (ADRD) in the preclinical period. Current tests focus on the proteinopathies associated with these diseases, but once these pathological variants develop it may be too late for treatments to be effective. We will identify a set of RNA and protein biomarkers in extracellular vesicles isolated from saliva to identify individuals in the preclinical period prior to the onset of proteinopathy when treatments may be more successful.

PI_NAMEs: KREILING, JILL  (contact);QUESENBERRY, PETER J.

PROGRAM_OFFICER_NAME: LUO, YUAN

PROJECT_TERMS: Address;Administrative Supplement;Aging;alpha synuclein;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease related dementia;Alzheimer’s disease biomarker;Amyloid;Amyloid beta-42;Amyloid deposition;Amyotrophic Lateral Sclerosis;Biological;Biological Assay;Biological Markers;biomarker identification;biomarker panel;Blood;Blood Tests;Brain;Cerebrospinal Fluid;Clinical;Cognition;Cognitive;cohort;cost;Custom;Data;Dementia;Dementia with Lewy Bodies;Development;Diagnosis;Diagnostic tests;Disease;Disease Progression;early detection biomarkers;Early Diagnosis;effective therapy;experimental study;extracellular vesicles;Frontotemporal Dementia;Functional disorder;Goals;high risk;Hospitals;Image;Impaired cognition;Individual;Inflammation;Intervention;Investigation;Liquid substance;lonely individuals;Measures;Messenger RNA;MicroRNAs;mild cognitive impairment;Monitor;Morbidity - disease rate;mortality;multidisciplinary;Nerve Degeneration;Neurodegenerative Disorders;neuroinflammation;Neurons;Outcome;Parkinson Disease;Participant;Pathologic;Pathology;Pathway interactions;Patients;PET positivity;Phase;Phenotype;point of care;Population;Positron-Emission Tomography;potential biomarker;pre-clinical;Predictive Value;Preparation;prevent;Prevention;Prevention strategy;protein biomarkers;protein TDP-43;Proteins;Proteomics;Publishing;recruit;Research;Research Personnel;Rhode Island;Risk;Risk Factors;RNA;Saliva;Salivary;screening;Screening procedure;System;tau Proteins;TBI Patients;Testing;therapeutic effectiveness;Therapeutic Intervention;Transcript;transcriptomics;Treatment Effectiveness;trend;Universities;Variant;Vesicle

PROJECT_TITLE: Salivary Extracellular Vesicles as Biomarkers for Alzheimer's Disease and Related Disorders


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Mental Illness;Prevention;Psychosis;Racial and Ethnic Minority Health Research;Schizophrenia;Serious Mental Illness;Social Determinants of Health

ORG_CITY: SAN BERNARDINO

ORG_DEPT: PSYCHOLOGY

ORG_NAME: CALIFORNIA STATE UNIV SAN BERNARDINO

PHR: 8. PROJECT NARRATIVE Psychosis prevents individuals from meeting their basic needs and leading meaningful lives and early intervention mitigates its effects, but services are often undermined by problems of engagement. The objective of this proposal is to advance the literature on effective pragmatic interventions for engagement, processes that lead to successful engagement, and the nature of engagement with services across time and contexts with a focus on individuals with FEP from hard-to-reach communities. Findings may help improve individuals’ engagement with public mental health services during the early stages of psychotic illness across the U.S.

PI_NAMEs: SANTOS, MARIA M (contact)

PROGRAM_OFFICER_NAME: SIMS, BELINDA ENITA

PROJECT_TERMS: Acculturation;Address;Affect;Appointment;Attention;Attenuated;behavior prediction;Behavioral;behavioral outcome;California;Caring;Characteristics;Client;Clinic;Clinical;Communication;Communities;community based service;Community Mental Health Services;Country;Development;Dimensions;Disease;Disease remission;Doctor of Medicine;Doctor of Philosophy;Early Intervention;effective intervention;ethnic minority population;Ethnic Origin;Evidence based intervention;experience;Family;Family Caregiver;Family member;family support;first episode psychosis;flexibility;follow-up;Functional impairment;functional outcomes;Future;Goals;health goals;high risk;Immigrant;Immigration;improved;Individual;Institution;interest;Intervention;Intervention Studies;Investigation;Latino;Latino Population;Life;Literature;Master of Public Health;Mediator;Mediator of activation protein;medication compliance;Medication Management;meetings;Mental Depression;Mental Health;Mental Health Services;Mentors;Methods;Modeling;National Institute of Mental Health;Nature;Outcome;Participant;Patients;Pattern;person centered;Persons;Phase;Population;Positive Reinforcements;pragmatic intervention;premature;prevent;Process;Psychoses;Psychosocial Assessment and Care;psychotic;Psychotic Disorders;psychotic symptoms;Public Health;Qualitative Methods;Quality of life;racial minority population;Randomized, Controlled Trials;Recommendation;Recovery;Research;Research Methodology;Research Project Grants;Resource-limited setting;Resources;Rewards;Risk;Role;Sampling;service engagement;service intervention;Services;Site;Support Groups;Symptoms;theories;Therapeutic;therapy design;Time;Training;Training Support;treatment as usual;Universities

PROJECT_TITLE: Optimizing Engagement in Services for First-Episode Psychosis (FEP) in the Community Mental Health Setting

STUDY_SECTION: SERV

STUDY_SECTION_NAME: Mental Health Services Study Section[SERV]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Neurofibromatosis;Neurosciences;Orphan Drug;Pediatric;Radiation Oncology;Rare Diseases

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

ORG_STATE: NY

PHR: Project Narrative Malignant peripheral nerve sheath tumors (MPNSTs) represent a group of highly aggressive soft tissue sarcomas with poor prognosis that occur in distinct clinical settings: neurofibromatosis 1 (NF1)-associated (45%), sporadic (45%) or radiotherapy (RT)-associated (10%). Most MPNSTs have NF1 loss (>90%hence, NF1- deficient), CDKN2A loss (~80%) and PRC2 loss (~60-80%), but they are resistant to MEK inhibitor alone due to feedback reactivation of PDGFRA/B pathways. Here, we propose a phase I/II study of a novel combination of ripretinib and binimetinib that targets both the PDGFR and MAPK pathways in patients with NF1-deficeint MPNSTs and to evaluate for biomarkers for MAPK pathway inhibition, as well as to investigate the MPNST tumor heterogeneity and plasticity during tumor evolution and in response to combination treatment using single cell analysis.

PI_NAMEs: CHI, PING  (contact)

PROGRAM_OFFICER_NAME: OLKHANUD, PUREVDORJ BALJINNYAM

PROJECT_TERMS: Adolescent;Adult;Alleles;ATAC-seq;Bar Codes;Benign;Biological Markers;Biological Models;Biopsy;Biopsy Specimen;CCR;CDKN2A gene;cell growth;Cells;chemotherapy;Clinical;clinical investigation;clinical practice;Clinical Treatment;Clonal Evolution;Combined Modality Therapy;Complex;Coupled;Custom;Defect;design;Developmental Therapeutics Program;Dose;epigenomics;Evaluation;Evolution;Family;Feedback;Future;Genomics;Goals;Growth;Heterogeneity;Human;In Vitro;in vivo;in vivo Model;inhibitor;inhibitor therapy;insight;interdisciplinary approach;loss of function;Loss of Heterozygosity;Malignant - descriptor;MAP Kinase Gene;Mediating;MEKs;Memorial Sloan-Kettering Cancer Center;Modeling;Molecular;Molecular Target;Mutate;Mutation;Neoplasm Metastasis;neoplastic cell;Neurofibromatosis 1;Neurofibrosarcoma;next generation sequencing;novel;novel therapeutics;Pathway interactions;Patients;PDGFRA gene;PDGFRB gene;Peripheral Nerve Sheath Neoplasm;Phase;phase I trial;Phase I/II Clinical Trial;Phosphorylation;Plexiform Neurofibroma;Polycomb;pre-clinical;Pre-Clinical Model;preclinical evaluation;Prognosis;Radiation therapy;Recommendation;Recurrence;Research Personnel;Resistance;resistance mechanism;Resources;response;Role;Safety;Sampling;Sarcoma;single cell analysis;single cell ATAC-seq;single-cell RNA sequencing;Site;Soft tissue sarcoma;Specimen;success;System;Systemic Therapy;Technology;therapeutic development;therapeutically effective;therapy resistant;tumor;tumor growth;tumor heterogeneity;Up-Regulation

PROJECT_TITLE: Understanding and targeting MAPK pathway activation in NF1-deficient malignant peripheral nerve sheath tumor (MPNST)

STUDY_SECTION: DT

STUDY_SECTION_NAME: Developmental Therapeutics Study Section[DT]


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Disability Research;Neurosciences;Physical Rehabilitation;Rehabilitation;Sleep Research;Stroke

ORG_CITY: LOS ANGELES

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

PHR: Project Narrative Brain stroke often leads to permanent disability of the hands. We are studying a new approach that can help restore hand function by using a device that delivers electricity to the brain during sleep. Sleep is known to improve learning and memory and here we plan to find out exactly how we can harness it in two brain regions to help people recover the use of their hand after a stroke.

PI_NAMEs: GULATI, TANUJ  (contact)

PROGRAM_OFFICER_NAME: DOPERALSKI, ADELE ELIZABETH

PROJECT_TERMS: Acute;awake;Back;Brain;Brain Injuries;Brain region;Cerebellar Cortex;Cerebellum;Chronic disability;Clinical;Contralateral;Coupled;Data;Devices;disability;efficacy testing;Electric Stimulation;Electricity;Electrophysiology (science);Etiology;Event;grasp;Hand;hand rehabilitation;Hippocampus;improved;injured;Knowledge;Learning;Learning Skill;learning strategy;Lifelong disability;Link;Memory;memory consolidation;Monitor;Motor;Motor Cortex;Motor disability;motor learning;motor recovery;motor skill learning;Motor Skills;Movement;Neocortex;neocortical;neural;Neurologic Symptoms;neurological rehabilitation;Neurons;neurophysiology;non rapid eye movement;novel;novel strategies;optogenetics;Outcome;Patients;Pattern;Performance;Persons;post stroke;Process;Rattus;Recovery;Recovery Support;rehabilitation strategy;Rehabilitation therapy;Research;Rodent;Role;skills;Sleep;sleep spindle;Sleep Stages;Slow-Wave Sleep;Stroke;stroke model;stroke recovery;Structure;System;Task Performances;Testing;Thalamic structure;Time;United States;Work

PROJECT_TITLE: A Neurophysiological Approach to Post-Stroke Motor Recovery

STUDY_SECTION: MFSR

STUDY_SECTION_NAME: Motor Function, Speech and Rehabilitation Study Section[MFSR]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Neurodegenerative;Neurosciences

ORG_CITY: ITHACA

ORG_DEPT: MISCELLANEOUS

ORG_NAME: CORNELL UNIVERSITY

PHR: We aim to determine the biochemical properties and functions of progranulin derived granulin peptides in the lysosome using cell culture, mouse models and human patient samples.

PI_NAMEs: HU, FENGHUA  (contact)

PROGRAM_OFFICER_NAME: SHEWMAKER, FRANK PAUL

PROJECT_TERMS: Affect;Aging;Antibodies;Binding;Binding Sites;Biochemical;Biological;Biological Assay;Brain;Cathepsins;Cd68;Cell Culture Techniques;Cell Physiology;cell type;Cells;Complement Activation;Data;Disease;Drug Targeting;Enzymes;Frontotemporal Lobar Degenerations;Functional disorder;Genetic Transcription;glial activation;glucosylceramidase;Glycoproteins;Glycoside Hydrolases;Glycosphingolipids;granulin;granulin 2;GRN gene;Homeostasis;Human;Impairment;Individual;Inflammation;inflammatory marker;insight;Length;lysosomal proteins;Lysosomes;Measures;Mediating;Membrane;Membrane Proteins;Microglia;Molecular Weight;mouse model;Mus;Mutation;Nerve Degeneration;Neurodegenerative Disorders;Neurons;novel;Pathology;Patients;Peptides;PGRN gene;Physiological;Process;programs;Property;protein biomarkers;protein TDP-43;Proteins;Proteomics;Regulation;Role;Sampling;Saposins;synaptic pruning;therapeutic development;Time;Tissues;trafficking;Work

PROJECT_TITLE: Lysosomal Function of Progranulin and Neurodegeneration

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


ORG_CITY: ANN ARBOR

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: PROJECT NARRATIVE  Signals from the gastrointestinal tract have strong effects on pancreatic endocrine control of glucose metabolism. The proposed research will investigate direct neuronal connections between the gut and the pancreas, so called entero-pancreatic plexus, and the role it plays in regulation of insulin secretion. This work will assess a novel way in which the gut can influence the pancreas providing for opportunities to identify novel targets for understanding the etiology and treatment for pervasive metabolic diseases

PI_NAMEs: SOKOLOV, MADINA MAKHMUTOVA (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Affect;anatomical topography;Anatomy;bariatric surgery;Beta Cell;blood glucose regulation;C-Peptide;Carbohydrates;Cell Nucleus;cholinergic;cholinergic neuron;Cholinergic Receptors;Communication;Coupled;Cues;Data;Diabetes Mellitus;Diet;Digestion;Dimensions;Duodenum;Endocrine;Endocrinology;Enteral;Enteric Nervous System;Etiology;Experimental Models;Foundations;Gastroenterology;gastrointestinal;Gastrointestinal Physiology;Gastrointestinal tract structure;Gene Expression;Gene Expression Profiling;Genomics;Glucose;glucose metabolism;Goals;Histologic;Hormones;Image;Immunohistochemistry;In Situ;In Situ Hybridization;in vivo;Infusion procedures;Insulin;insulin regulation;insulin secretion;Intake;intravital imaging;islet;Islets of Langerhans;Laboratories;Light;Link;Liquid substance;Literature;Mentors;Metabolic Diseases;Modeling;Modernization;Molecular;Molecular Profiling;Muscarinic M3 Receptor;nerve supply;neural;Neurons;Nicotinic Receptors;novel;Nutrient;Operative Surgical Procedures;Organ;Pancreas;pancreas imaging;Pancreatic Endocrine Secretion;pancreatic islet function;pancreatic juice;Pathway interactions;Pharmacogenetics;pharmacologic;Pharmacologic Substance;Physiological;Physiology;Plasma;Play;postsynaptic;Process;Property;Regulation;Reporter;Reporting;Research;Research Project Grants;response;Role;Sensory;sensory input;Serum;Signal Transduction;single nucleus RNA-sequencing;Solid;Stomach;Structure of beta Cell of islet;Study models;success;System;Technology;Testing;Therapeutic;Time;Visualization;Work

PROJECT_TITLE: Neuronal gut-pancreas axis and its effect on pancreatic islet physiology and insulin secretion


NIH_SPENDING_CATS: Bioengineering;Neurosciences

ORG_CITY: HERSHEY

ORG_NAME: PENNSYLVANIA STATE UNIV HERSHEY MED CTR

PHR: Project Narrative Here we propose to use state-of-the-art imaging methods to study the molecular mechanisms of neurite outgrowth. This is important for human health, because this guidance impacts neuronal regeneration after traumatic or ischemic insult, and is required for normal brain development.

PI_NAMEs: SWULIUS, MATTHEW  (contact)

PROGRAM_OFFICER_NAME: TYLER, WILLIAM A

PROJECT_TERMS: Actin-Binding Protein;Actins;Appearance;Architecture;base;Behavior;Binding;Binding Proteins;Brain;Cell membrane;Cells;Cellular Structures;Chemicals;cofilin;Complex;crosslink;Crosslinker;Cryo-electron tomography;Cytoskeletal Proteins;Cytoskeleton;Data;Development;Distal;Exclusion;experimental study;extracellular;F-Actin;fascin;Filament;Filopodia;flexibility;Fluorescence;fluorescence imaging;Goals;Growth Cones;Health;Hippocampus;Homologous Gene;Human;imaging modality;Immunofluorescence Immunologic;In Situ;injury recovery;Ischemia;Length;LIM Domain Kinase 1;Link;live cell imaging;macromolecular assembly;mechanical signal;Mechanics;Microfilaments;Modification;Molecular;Molecular Structure;Motility;nanoarchitecture;nanometer resolution;Natural regeneration;Nerve Tissue;Neurites;neuron regeneration;Neurons;Neuropil;novel;pharmacologic;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphotransferases;Play;Pliability;Process;Property;Protein Dephosphorylation;Proteins;receptor;Resolution;Role;Running;Signal Pathway;Stains;Structure;Testing;Time;Translating

PROJECT_TITLE: Using cryo-electron tomography and live-cell fluorescent imaging to study the role of cofilin in regulating neuronal filopodial structure and dynamics

STUDY_SECTION: NC

STUDY_SECTION_NAME: Neuronal Communications Study Section[NC]


ED_INST_TYPE: SCHOOLS OF OSTEOPATHIC MEDICINE

NIH_SPENDING_CATS: Cancer;Cervical Cancer;Infectious Diseases;Sexually Transmitted Infections;Women's Health Research

ORG_CITY: INDIANAPOLIS

ORG_NAME: MARIAN UNIVERSITY

ORG_STATE: IN

PHR: Project Narrative Cervical cancer is the second most common cancer in women worldwide and is a leading cause of cancer- related death in women in underdeveloped countries. Although most cervical cancer is caused by human papillomavirus (HPV), HPV infection alone is not sufficient for women to develop cancer. Our goal in this proposal is to determine if Chlamydia infection can serve as a co-factor that can trigger women infected with HPV to develop cancer, by showing that Chlamydia infection can make HPV infection more efficient.

PI_NAMEs: DERBIGNY, WILBERT A (contact)

PROGRAM_OFFICER_NAME: ALARCON, RODOLFO M

PROJECT_TERMS: Acceleration;Agreement;Animal Model;Apoptosis;Autoimmunity;Basal Cell;Biological;Biological Assay;Biological Markers;Biological Models;Cancer Etiology;Cancerous;Cell Survival;cell transformation;Cells;Cervical;cervical carcinogenesis;Cervical Squamous Cell Carcinoma;Chlamydia;Chlamydia Infections;Chlamydia muridarum;Chlamydia trachomatis;Chromatin;co-infection;cofactor;Data;Developing Countries;Development;DNA Damage;DNA Repair Pathway;efficacy evaluation;Enzyme-Linked Immunosorbent Assay;epidemiologic data;Epidemiology;Epigenetic Process;Epithelial Cell Proliferation;Epithelial Cells;Epithelium;Exposure to;Future;Goals;Heterochromatin;Hormonal;HPV E7;Human;Human papilloma virus infection;Human Papillomavirus;Immune response;Impairment;In Vitro;in vivo;Infection;Inflammation Mediators;Inflammatory;innovation;insight;Intercellular Junctions;Invaded;Investigation;keratinocyte;lifetime risk;Link;Malignant Female Reproductive System Neoplasm;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Mammalian Oviducts;MEKs;Meta-Analysis;monolayer;mouse model;Mus;Neoplasm Metastasis;Neoplasms;novel;Oncogenic;Outcome;Papillomavirus;Papillomavirus Infections;Papillomavirus Transforming Protein E6;pathogen;Pathogenesis;Pathology;Pathway interactions;Patients;Permeability;Play;Predisposition;premalignant;prevent;Proteins;Reporting;reproductive tract;response;Risk;Role;senescence;sensor;Sexual Transmission;Sexually Transmitted Diseases;Signal Pathway;Signal Transduction;Squamous cell carcinoma;Stratum Basale;targeted treatment;Testing;Therapeutic Intervention;Tissues;TLR3 gene;transcriptome;transcriptomics;tumor;tumorigenesis;unvaccinated;vaginal microbiota;Woman;Women's mortality;women's reproductive health

PROJECT_TITLE: Investigating whether chlamydia trachomatis can increase the infectivity of HPV during genital tract infections

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IIDA-S(90)]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Digestive Diseases;Genetics;Human Genome;Rare Diseases

ORG_CITY: ALBUQUERQUE

ORG_NAME: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR

ORG_STATE: NM

PHR: Narrative  Adenoid Cystic Carcinoma (ACC) is a slow-growing salivary gland tumor that is treated by surgery and radiation, often leaving patients disfigured and with significant morbidity. Many ACC patients survive more than 10 years after the standard therapy of surgery and radiation, but a fraction succumb much more quickly and others acquire distant metastases or relapse 5 or more years after the initial treatment. This project will use detailed RNA sequencing analyses to learn more about the biology of ACC tumors, to identify the patients at highest risk of relapse and to translate our findings to clinical laboratories so the information can be successfully used to help patients.

PI_NAMEs: PALANISAMY, VISWANATHAN  (contact)

PROGRAM_OFFICER_NAME: CHEN, ZHONG

PROJECT_TERMS: Adenoid Cystic Carcinoma;Bioinformatics;Biological Markers;Biology;biomarker development;Breast;C-terminal;Cell Line;Cell model;Cells;Characteristics;Chimeric Proteins;Chromosomes;Clinic;Clinical;cohort;Data;Denmark;Development;Distant Metastasis;driver mutation;Enhancers;Epigenetic Process;Event;follow-up;Gene Expression;Gene Expression Profile;Gene Expression Profiling;Genes;Genetic Transcription;Genomics;Glean;Goals;Growth;Heterogeneity;high risk;Human;Institution;Laboratories;Lacrimal gland structure;Lead;Learning;Length;Methods;migration;Molecular;Molecular Biology;Morbidity - disease rate;Morphology;Mus;Mutation;MYB gene;MYBL1 gene;N-terminal;NFIB gene;novel therapeutic intervention;Oncogenic;Oncoproteins;Operative Surgical Procedures;overexpression;Paper;patient derived xenograft model;patient prognosis;patient subsets;Patients;Positioning Attribute;Prognosis;promoter;Proteins;Publishing;Radiation;Reconstructive Surgical Procedures;Recurrence;Relapse;relapse risk;Research;Role;Salivary Gland Adenoid Cystic Carcinoma;Salivary Gland Neoplasms;Salivary Glands;sample archive;Sampling;Shapes;Skin;Subgroup;Testing;Tissues;Training;transcription factor;transcriptome sequencing;Translating;tumor;usability;Validation;Work

PROJECT_TITLE: Mutations and Target Genes in Adenoid Cystic Carcinoma

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Climate-Related Exposures and Conditions;Genetics;Human Genome;Skin Cancer

ORG_CITY: PULLMAN

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: WASHINGTON STATE UNIVERSITY

PHR: Project Narrative: Genome sequencing of melanomas and other skin cancers have identified many mutations that reoccur in tumors derived from different patients, and it has been presumed that these recurring mutations have important roles in causing the tumor. However, our data indicate that many of these recurring mutations are likely not important for carcinogenesis, but instead arise from elevated UV damage caused by the binding of transcription factor proteins to DNA. This proposal will use a new method to map the levels of UV damage at recurring mutation sites, in order to prioritize likely driver mutations in skin cancers by triaging those mutations that are merely caused by elevated UV damage levels.

PI_NAMEs: WYRICK, JOHN J (contact)

PROGRAM_OFFICER_NAME: HUMBLE, MICHAEL C

PROJECT_TERMS: Adenine;Affect;base;Binding;Binding Sites;Bioinformatics;bioinformatics pipeline;BRAF gene;cancer cell;Cancer cell line;Cancer Etiology;cancer genome;cancer type;candidate identification;carcinogenesis;carcinogenicity;Cell Line;Cell Proliferation;Cell Survival;Cells;Codon Nucleotides;Data;Data Set;DNA;DNA Binding;DNA Damage;DNA mapping;driver mutation;Early Promoters;Elements;endonuclease;Excision Repair;Exons;Exposure to;Family;Frequencies;Gene Proteins;Genes;Genome;genome sequencing;genomic locus;Growth;Human;Human Genome;In Vitro;Individual;keratinocyte;Lesion;Link;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Maps;Measures;melanocyte;Melanoma;melanomagenesis;Methods;Molecular;Mutate;Mutation;Nucleotide Excision Repair;Nucleotides;Oncogenic;Pathway interactions;Patients;Phosphotransferases;Proteins;Protocols documentation;Publishing;Pyrimidine;Pyrimidine Dimers;Recurrence;repaired;Resolution;response;Role;Sampling;Site;Skin;Skin Cancer;Testing;Thymine;transcription factor;Triage;tumor;Tumor-Derived;ultraviolet;ultraviolet damage;ultraviolet irradiation;Ultraviolet Rays;Untranslated RNA;UV induced;UV Radiation Exposure;Yeasts

PROJECT_TITLE: Identifying recurrent driver mutations in skin cancers by targeted UV damage sequencing

STUDY_SECTION: CE

STUDY_SECTION_NAME: Cancer Etiology Study Section[CE]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Heart Disease;Heart Disease - Coronary Heart Disease;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Regenerative Medicine

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative Heart disease is a leading cause of death in the U.S., partly due to the inability of muscle cells in the adult heart to divide. In sharp contrast, muscle cells in young mice divide robustly after a heart attack and can regenerate. Completion of the proposed studies will identify proteins in the young mouse heart that promote cardiac cell division, with the hope of applying these findings to treat human cardiovascular diseases.

PI_NAMEs: ALI, SHAH RUKH (contact)

PROGRAM_OFFICER_NAME: NEILSON, KAREN MARY

PROJECT_TERMS: Address;Adult;Advisory Committees;Age;Apical;Award;Beta Cell;Binding;Biology;Blood Vessels;California;Candidate Disease Gene;Cardiac;Cardiac Myocytes;cardiac regeneration;Cardiology;Cardiovascular Diseases;Cardiovascular system;career development;Cause of Death;Cell Count;Cell Cycle Arrest;Cell Death;Cell division;Cell Lineage;Cell secretion;Cell Transplantation;cell type;Cells;Cessation of life;Cicatrix;conditional knockout;Data;defined contribution;Deterioration;Development;Developmental Biology;Endothelial Cells;Endothelium;Excision;Exhibits;experience;experimental study;Failure;Fellowship;Fibroblasts;Genetic Models;healthcare burden;Healthcare Systems;Heart;Heart Diseases;Heart failure;heart function;Heart Transplantation;Human;IGF2 gene;Impairment;improved;Injury;insight;instructor;Insulin Receptor;Insulin-Like Growth Factor Binding Protein 3;Insulin-Like Growth-Factor-Binding Proteins;Internal Medicine;ischemic cardiomyopathy;Knockout Mice;Knowledge;Laboratories;Laboratory Study;Life;Maps;Mechanics;Mediating;Mentors;Micro Array Data;Mitogens;Mitosis;Mitotic;Molecular;mouse model;Mus;Muscle Cells;mutant;Myocardial Infarction;Myocardial Ischemia;Natural regeneration;Neonatal;neonatal injury;neonatal mice;neonate;novel;novel therapeutics;old mice;Operative Surgical Procedures;Organ;Output;overexpression;paracrine;Patients;Pharmaceutical Preparations;Physicians;Proliferating;Protein Family;Protein Secretion;Proteins;Recombinant Insulin-Like Growth Factor;Recombinants;regenerative;regenerative therapy;Research;Research Personnel;Residencies;response to injury;Role;San Francisco;Scientist;Serum;Signal Induction;Signal Pathway;Signal Transduction;Source;Texas;therapeutic candidate;Tissues;Training;Translating;Universities;Ventricular;Vocational Guidance;Writing

PROJECT_TITLE: Role of IGFBP3 in Neonatal Heart Regeneration

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(JA)]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Machine Learning and Artificial Intelligence;Neurosciences

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project narrative Nerve damage during neurosurgery is often caused by the challenge of differentiating nerves from their surrounding tissues. This project seeks to design, construct, and implement a new tool that can visualize nerves across the whole surgical field and place it directly into the hands of skull-base surgeons. In the long term, a tool such as this could result in a decrease in nerve injury rates and a reduction of the related morbidities.

PI_NAMEs: HARPER, DANIELLE J. (contact)

PROGRAM_OFFICER_NAME: KUMSA, DOE WONDWOSSEN

PROJECT_TERMS: Acoustic Neuroma;Address;Affect;Anatomy;Area;Award;Back;Biophotonics;Blood Vessels;Boston;Brain;Cancerous;career;career development;Clinical;Collagen;Complex;contrast enhanced;Cranial Nerves;Crowding;Data;deep learning;deep learning algorithm;Deformity;design;Electric Stimulation;electrical measurement;Electromyography;Environment;Equipment;Evaluation;Excision;experience;Fascicle;first-in-human;Fluorescence;Focus Groups;Funding;General Hospitals;Goals;Growth;Hand;Home;Hospitals;human study;iatrogenic injury;Image;image guided;image guided therapy;Image-Guided Surgery;Imaging Device;imaging facilities;imaging modality;Imaging Techniques;Imaging technology;improved;Injury;Institution;invention;K-Series Research Career Programs;Label;Laboratories;Lasers;Lead;Lipid Bilayers;Location;Maps;Massachusetts;Measures;medical schools;meningioma;Mentors;Microscope;Morbidity - disease rate;Motion;Multimodal Imaging;Nerve;nerve damage;Nerve Fibers;nerve injury;neuroimaging;neurosensory;Neurosurgeon;neurosurgery;novel;Olfactory Nerve;Operative Surgical Procedures;Optical Coherence Tomography;optical imaging;Optics;Outcome;Patient-Focused Outcomes;Performance;Phase;Postdoctoral Fellow;practical application;Preparation;real-time images;Research;research and development;Research Design;Resolution;Resources;Sampling;skills;skull base;Specificity;Spectrum Analysis;spine bone structure;Supervision;Surface;Surgeon;System;Technical Expertise;Techniques;Technology;Testing;Time;Tissues;tool;Training;Translational Research;tumor;United States National Institutes of Health;Universities;validation studies;Variant;Vertebral column;Visualization;Woman;Work

PROJECT_TITLE: Intraoperative Identification of Cranial Nerves in Skull Base Surgery Using Polarization Sensitive Optical Coherence Tomography

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-2 Study Section [NST-2]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Effects of Indoor Air Pollution;Mental Health;Neurosciences;Pediatric

ORG_CITY: BOYS TOWN

ORG_NAME: FATHER FLANAGAN'S BOYS' HOME

ORG_STATE: NE

PHR: Project Narrative Home radon is a ubiquitous carcinogen that is known to alter inflammatory activity in the body and poses a significant threat to families across the United States. Despite abundant research linking even low-grade chronic inflammation to aberrations in neural development, and to the development of psychological symptoms, research has yet to examine the degree to which radon exposure is linked to these neural and behavioral phenotypes. The present study will leverage a robust multimodal neuroimaging approach, coupled with blood-based markers of peripheral inflammation and psychometrically-sound neuropsychological assessments, to investigate the pathways through which chronic radon exposure and toxin-induced changes in inflammation are associated with brain function, and cognitive and mental health in youths.

PI_NAMEs: TAYLOR, BRITTANY  (contact)

PROGRAM_OFFICER_NAME: GRAY, KIMBERLY A

PROJECT_TERMS: Address;Adolescent;Adolescent Development;Air;Area;Attention;Awareness;Behavioral;behavioral phenotyping;Biological Process;biological systems;Blood specimen;blood-based biomarker;Body System;Brain;brain health;carcinogenicity;Carcinogens;Child Development;Chronic;Cigarette;Clinical;Cognition;Cognitive;cognitive ability;cognitive control;cognitive development;cohort;Country;Coupled;cytokine;Dangerousness;Data;depressive symptoms;design;Development;Developmental Process;emotion regulation;Emotional;Emotions;Environment;Environmental Health;executive function;Exhibits;Exposure to;Family;Foundations;Future;Gases;Goals;Health;Health Policy;Home;Incidence;indexing;Inflammation;Inflammatory;inflammatory marker;innovation;Investigation;Knowledge;Laboratories;Link;Magnetic Resonance Imaging;Magnetoencephalography;Malignant neoplasm of lung;Malignant Neoplasms;Measurement;Measures;Mediating;Mental disorders;Mental Health;multimodal neuroimaging;multimodality;National Institute of Environmental Health Sciences;neural;neural circuit;Neurocognitive;neurodevelopment;neuroimaging;Neuropsychology;Organ;Outcome;Outcome Study;Pathway interactions;Pattern;Peripheral;Persons;physical conditioning;Process;Psyche structure;psychological symptom;Psychometrics;Public Health;Radioactive;Radon;Recommendation;Research;Risk;Role;Severities;Shapes;Smoking;Soil;sound;Source;Strategic Planning;System;Techniques;Tissues;Toxic effect;Toxic Environmental Substances;toxicant;Toxin;United States;United States Environmental Protection Agency;Well in self;Work;Youth

PROJECT_TITLE: Pathways to mental health: the mediating role of altered cytokines on the relationship between chronic home radon exposure and emotional neural circuitry in developing youths

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Drug Abuse (NIDA only);HIV/AIDS;Lung;Lung Cancer;Neurosciences;Prevention;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Continuing to reduce the rate of tobacco smoking in the US depends on the availability of rigorous training programs to ensure the availability of scientists trained in patient-oriented tobacco dependence research. For the first cycle of my K24, I provided training to 32 mentees (21 new since 2018), yielding 50 papers with mentees and 7 papers with mentees under review or in revision (>230 total by mentees) and 32 grants, including 5 Ks and 11 R01s, 3 as a New Investigator PI, vs. 25 mentees, 34 publications with mentees, and 2 Ks and 2 R01s in the preceding 17 years. For the first cycle of the K24, I also augmented my tobacco POR by building expertise in implementation science through training and by pilot testing the use of the nicotine metabolite ratio for personalizing tobacco treatment as an implementation strategy to increase use of tobacco treatments, which has led to six new grants in tobacco and implementation science, 4 focused on testing the NMR in varying clinical settings. In this renewal, I will sustain the mentoring program in tobacco and implementation science POR that I established with the first K24 cycle and continue to grow our tobacco and implementation science research, including in the context of HIV clinical care.

PI_NAMEs: SCHNOLL, ROBERT ADAM (contact)

PROGRAM_OFFICER_NAME: FITZ-RANDOLPH, MARCY ESTHER

PROJECT_TERMS: Address;Appointment;Area;Award;behavior test;behavioral economics;Biological Markers;cancer care;Cancer Center;Cancer Patient;Cardiology;care delivery;career;career development;Caring;Cessation of life;Clinical;clinical care;clinical practice;Communicable Diseases;Dedications;design;Dissemination and Implementation;Educational process of instructing;Educational workshop;Effectiveness;Electronic Health Record;Ensure;Evidence based treatment;Extramural Activities;Faculty;Funding;genetic testing;Goals;Grant;Health;HIV;Hospitalization;implementation research;implementation science;implementation strategy;improved;Individual;Inpatients;Intention;Malignant Neoplasms;Mentors;Mentorship;Metabolism;Methods;N-octanoylglucosylamine;Neurology;next generation;Nicotine;Nicotine Dependence;nicotine treatment;nicotine use;Oncology;Paper;patient oriented;patient oriented research;Patients;Pennsylvania;personalized approach;personalized medicine;Pharmaceutical Preparations;Pilot Projects;pilot test;Pragmatic clinical trial;premature;Primary Care;Productivity;programs;Publications;recruit;reduce tobacco use;Research;Research Personnel;Research Project Grants;Science;Scientist;Smoker;Smoking;Structure;student mentoring;Students;symposium;Testing;Time;Tobacco;tobacco control;Tobacco Dependence;Tobacco smoking behavior;Tobacco use;Training;Training Programs;Treatment Effectiveness;Underrepresented Minority;United States National Institutes of Health;Universities;varenicline;Wages;Washington;Work;working group

PROJECT_TITLE: A Mentoring Program in Patient-Oriented Tobacco Dependence and Implementation Science Research

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: NARRATIVE Transporters in the kidney play important roles in the elimination of drugs, nutrients, and hormones. SLC22A24, a transporter, has been shown to transport drugs and hormones across cell membranes. In this study, we will discover its role in the kidney of mice and healthy volunteers; our studies will lead to a new understanding of the role of SLC22A24 in human biology and drug response.

PI_NAMEs: GIACOMINI, KATHLEEN M (contact)

PROGRAM_OFFICER_NAME: KODURI, SAILAJA

PROJECT_TERMS: absorption;Alleles;analytical method;apical membrane;basolateral membrane;Biological;Biological Assay;Biology;Blood;Cell Line;Cell membrane;Cells;Cellular Assay;clinical phenotype;Computer Analysis;Confocal Microscopy;CRISPR/Cas technology;design;drug disposition;Drug Kinetics;Drug Prescriptions;Drug Transport;Evaluation;Excision;Exhibits;Expression Profiling;Family;Gene Frequency;genetic association;Genetic Polymorphism;genome-wide;Genomics;Glucuronides;Goals;healthy volunteer;Homology Modeling;Hormones;Human;Human Biology;In Vitro;Individual;Isotopes;Kidney;Knock-in;Laboratories;Ligands;liquid chromatography mass spectrometry;Liquid substance;Measures;member;Membrane Transport Proteins;metabolomics;Methods;Methotrexate;mouse model;Mus;novel;Nutrient;Organic Anion Transporters;Orphan;Orthologous Gene;Participant;Pharmaceutical Preparations;pharmacologic;Pharmacology;Physiological;Physiology;Plasma;Play;polarized cell;Population;preference;Proteins;Proximal Kidney Tubules;Renal clearance function;Research;response;Role;Signal Transduction;solute;stable cell line;steroid hormone;Steroids;Sulfate;Testing;Therapeutic;Transgenic Mice;uptake;urinary;Variant;Xenobiotics

PROJECT_TITLE: Characterizing the physiological and pharmacological roles of SLC22A24

STUDY_SECTION: XNDA

STUDY_SECTION_NAME: Xenobiotic and Nutrient Disposition and Action Study Section[XNDA]