NIH_SPENDING_CATS: Behavioral and Social Science;Biodefense and Related Countermeasures;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Cost Effectiveness Research;Depression;Dissemination and Implementation Research;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Mental Health;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: WASHINGTON

ORG_NAME: GEORGE WASHINGTON UNIVERSITY

ORG_STATE: DC

PHR: PROJECT NARRATIVE The goal is to improve mental health of minority and other vulnerable populations disproportionately affected by COVID-19. In addition, we will evaluate the impact of mental health services on COVID-19 mitigation strategies such as prevention behaviors, receiving vaccinations, and safe healthcare utilization. Successful completion of this study will contribute to the NIMH Strategic Plan employing implementation science to maximize the public health impact of research for effectiveness and reach of mental health services, especially for minority groups and other underserved populations in the United States.

PI_NAMEs: KOHRT, BRANDON ALAN (contact)

PROGRAM_OFFICER_NAME: MAVANDADI, SHAHRZAD

PROJECT_TERMS: Address;Adherence;Adoption;adverse outcome;Affect;American;arm;Attitude;Behavior;behavior change;Black race;Chronic Disease;Cities;Client;Collaborations;Communicable Diseases;Communities;community advisory board;community engagement;community organizations;Community Participation;community setting;Competence;Contracts;cost effectiveness;cost-effectiveness ratio;COVID-19;COVID-19 impact;COVID-19 intervention;COVID-19 mortality;COVID-19 risk;COVID-19 susceptibility;Death Rate;depressive symptoms;design;digital monitoring;Distress;Economics;Effectiveness;effectiveness research;Emergency department visit;Emergency Situation;Ethnic Origin;evidence base;experience;experimental arm;Funding;Goals;Health behavior;health care service utilization;health disparity populations;health training;Hospitalization;implementation evaluation;implementation measures;implementation science;improved;improved outcome;incremental cost-effectiveness;innovation;Intervention;Knowledge;Latinx;Link;Maintenance;Manuals;Measures;Mediation;member;Mental Depression;Mental Health;Mental health promotion;Mental Health Services;Minority Groups;minority health;Mission;Modeling;National Institute of Mental Health;New York City;Nonprofit Organizations;Outcome;pandemic disease;Partnership Practice;Persons;Policies;policy recommendation;Population;Prevention;primary outcome;psychologic;Public Health;Race;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;remote delivery;Research;response;Safety;SARS-CoV-2 infection;Schools;self reported behavior;Service delivery model;service organization;Services;services as usual;social;Social Distance;socioeconomic disadvantage;Specialist;Strategic Planning;Symptoms;Training;treatment arm;Underserved Population;United States;United States National Institutes of Health;Universities;Vaccination;Vulnerable Populations;Washington;Work

PROJECT_TITLE: REstoring mental health after COVID-19 through commUnity-based Psychological services in New York City (RECOUP-NY)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-H(58)R]


ADMINISTERING_IC: CA

ARRA_FUNDED: N

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Cervical Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Prevention;Sexually Transmitted Infections;Women's Health Research

ORG_CITY: BOSTON

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: Project Narrative The Botswana CASCADE Clinical Trials Site will study strategies for preventing cervical cancer in women living with HIV. Cervical cancer is the leading cause of death for women on HIV treatment in Botswana and current approaches have not succeeded in reaching population with effective preventative services. Studies to be conducted will focus on strategies to improve access to screening, effectiveness of cervical screening, and access and treatment effectiveness of identified precancers.

PI_NAMEs: DRYDEN-PETERSON, SCOTT  (contact);RAMOGOLA-MASIRE, DOREEN

PROGRAM_OFFICER_NAME: FRECH, MARIA SILVINA

PROJECT_TERMS: Ablation;access disparities;Acquired Immunodeficiency Syndrome;Africa;African;aged;AIDS clinical trial group;AIDS related cancer;antenatal care;antiretroviral therapy;Area;Botswana;breast cancer diagnosis;cancer diagnosis;cancer invasiveness;cancer prevention;cancer therapy;Caring;Cause of Death;Cervical;Cervical Cancer Screening;Cervical dysplasia;Cessation of life;Clinical Research;clinical research site;Clinical Trials;Clinical Trials Network;Clinical Trials Unit;cohort;Collaborations;Communities;community engagement;Community Health Education;comparative trial;Consumption;Country;COVID-19 Prevention Network;Cryptococcosis;Cryptococcus;Data;data management;data quality;Devices;Dysplasia;Early Diagnosis;Early treatment;Economic Factors;Effectiveness;effectiveness evaluation;Enrollment;Ethics;Ethnic Origin;Evaluation;experience;Female Adolescents;Geography;Health Services Accessibility;Health system;High Prevalence;HIV;HIV diagnosis;HPV positive;Human Papilloma Virus Vaccination;Human Papillomavirus;Immunotherapy;Impairment;Improve Access;improved;Income;innovation;International;International Agencies;International Maternal Pediatric Adolescent AIDS Clinical Trials;Laboratories;Language;Lesion;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Mentors;mortality;new technology;novel;Observational Study;Oncology;Outcome;participant enrollment;patient navigation;Patient Recruitments;Patient risk;Patients;Performance;Persons;Population;pragmatic trial;premalignant;Prevalence;prevent;Prevention;Preventive service;programs;prospective;Protocols documentation;quality assurance;Quality Control;randomized trial;Relapse;Research;Research Personnel;research study;Resources;Sampling;screening;screening program;Site;Southern Africa;Target Populations;Techniques;Technology;Time;Training;Treatment Effectiveness;treatment optimization;treatment program;Tuberculosis;United States National Institutes of Health;Universal Coverage;uptake;Vaccines;Viral;Woman;Women's mortality

PROJECT_TITLE: Botswana CASCADE Clinical Trials Site


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Natural Products

ORG_CITY: IRVINE

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

ORG_STATE: CA

PHR: Project Narrative The proposed research program focuses on the efficient chemical synthesis of structurally complex and biologically active diterpenoid natural products. The chemistry that underpins all of this work takes advantage of the inherently high chemoselectivity of modern radical chemistry, and involves two major strategic innovations: 1. cobalt-catalyzed, MHAT-induced radical polycyclizations, and 2. novel applications of hydrazones in radical bicyclizations. We leverage these key strategies to arrive at complex diterpene targets via sequences that are dramatically shorter than the state-of-the-art, and that permit collaborative biological studies in the antiviral, antibacterial, and immunosuppressive areas.

PI_NAMEs: VANDERWAL, CHRISTOPHER D (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TITLE: Chemical Synthesis of Bioactive Diterpenoids


ED_INST_TYPE: SCHOOLS OF MEDICINE

ORG_CITY: BALTIMORE

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: NARRATIVE We propose to characterize a new pathway that regulates JMJD1A function through ubiquitination and acetylation, modifications potentially relevant to AR/MYC activities and prostate cancer progression. Our studies should reveal new strategies to antagonize JMJD1A and concomitantly inhibit AR/MYC activities as potential prostate cancer therapy.

PI_NAMEs: QI, JIANFEI  (contact)

PROGRAM_OFFICER_NAME: LIU, ZHIHUI

PROJECT_TERMS: Acetylation;advanced prostate cancer;androgen deprivation therapy;androgen independent prostate cancer;Androgen Receptor;antagonist;Binding;Binding Proteins;Biochemical;Bromodomains and extra-terminal domain inhibitor;c-myc Genes;Cancer Cell Growth;cancer recurrence;cancer subtypes;cancer therapy;cancer type;Castration;cell growth;Cells;ChIP-seq;Chromatin;clinically relevant;Data;demethylation;Development;Down-Regulation;enzalutamide;EP300 gene;Exhibits;Family;Genes;Growth;histone demethylase;hormone therapy;Human;In Vitro;inhibitor;knock-down;Knock-out;Lysine;Malignant neoplasm of prostate;Modification;Neoadjuvant Therapy;Neuroendocrine Prostate Cancer;novel;Oncoproteins;p300/CBP-Associated Factor;Pathway interactions;patient prognosis;Play;prostate cancer cell;prostate cancer model;prostate cancer progression;Prostate Cancer therapy;Protein Family;Proteins;PTEN gene;recruit;Recurrence;Regulation;Resistance;RNA Splicing;Role;Stains;Testing;therapeutic target;Tissue Microarray;Tissues;transcriptome sequencing;tumor growth;Tumor Promotion;tumor xenograft;ubiquitin ligase;Ubiquitination;Variant;VCaP;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Role of JMJD1A modifications in castration resistance of prostate cancer

STUDY_SECTION: MONC

STUDY_SECTION_NAME: Molecular Oncogenesis Study Section[MONC]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cardiovascular;Congenital Heart Disease;Congenital Structural Anomalies;Heart Disease;Infant Mortality;Lung;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Rare Diseases

ORG_CITY: PORTLAND

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE Tetralogy of Fallot (TOF) is a critical congenital heart disease that affects about 1 in 2520 babies born in the US each year, and frequently requires lifesaving surgery within the first year of life and valve replacement. Due to the characteristic blood flow dynamics in TOF, fetal semilunar heart valves and their supporting structures are susceptible to flow-induced prenatal pathophysiological remodeling that alters deposition of important constituents (such as collagen and elastin) in valve leaflets, impacting their competence. Using in vivo echocardiography and correlative multiscale imaging, as well as computational and mathematical modeling, this project will establish predictive relationships between abnormal blood flow in fetal TOF and detrimental remodeling of valves, ultimately guiding lifesaving treatment strategies for babies with TOF.

PI_NAMEs: RUGONYI, SANDRA  (contact)

PROGRAM_OFFICER_NAME: SCHRAMM, CHARLENE A

PROJECT_TERMS: 3-Dimensional;Address;Affect;Aorta;Arteries;Birds;Birth;Blood;Blood flow;Cardiac;Cell Differentiation process;Cells;Characteristics;Chemicals;Chick;Chick Embryo;Collagen;Collagen Fiber;Competence;Computer Models;Confocal Microscopy;Congenital atresia of pulmonary valve;congenital heart abnormality;Critical Congenital Heart Defects;critical congenital heart disease;Cues;Data;Deposition;Development;Diameter;Echocardiography;Elastin;Elastin Fiber;Embryo;Event;Exhibits;experience;Extracellular Matrix;Face;fetal;Fetal Development;fetal diagnosis;Fetal Heart;Fetus;Functional disorder;Future;hatching;Heart;heart function;heart imaging;Heart Valves;hemodynamics;Human;Image;imaging modality;Impairment;improved;in vivo;in vivo imaging;Intervention;Knowledge;Left ventricular structure;Life;light microscopy;Longitudinal Studies;Lung;Maps;mathematical model;microCT;Microscopy;Modeling;Morphology;Natural regeneration;Newborn Infant;novel;Operative Surgical Procedures;Organ;Pathologic;Pattern;predictive modeling;Predisposition;prenatal;Process;Pulmonary artery structure;Pulmonary Valve Stenosis;Resolution;response;Right ventricular structure;Scanning Electron Microscopy;semilunar valve;shear stress;Side;Smooth Muscle Myocytes;Structure;Surface;Testing;Tetralogy of Fallot;Time;Tissues;treatment strategy;valve replacement;Ventricular Septal Defects

PROJECT_TITLE: Prenatal valve formation in congenital heart disease

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Data Science;Infectious Diseases;Networking and Information Technology R&D (NITRD)

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: The Boston University Summer Institute for Research Education in Biostatistics and Data Science (BU SIBS) is a five-week in-residence program, followed by a period of continued remote research, designed to build skills and to interest undergraduates, recent graduates and early graduate students in the many exciting opportunities in the field of Biostatistics. The trainees’ future role in public health will be enhanced due to their early exposure to the foundations of biostatistical analysis, epidemiological analysis, infectious disease modeling, design and analysis of clinical trials and statistical genetics analysis within a data science framework.

PI_NAMEs: HICKS, JACQUELINE MILTON;JENKINS, HELEN E. (contact)

PROGRAM_OFFICER_NAME: GEZMU, MISRAK

PROJECT_TERMS: Academia;Active Learning;big biomedical data;Big Data;Biomedical Research;Biometry;Boston;career;Career Choice;clinical trial analysis;Clinical Trials;Communicable Diseases;Complex;computational platform;Computer Models;Computer software;Computers;COVID-19;Creativeness;data integrity;data platform;Data Science;Data Scientist;Data Set;data visualization;design;Discipline;education research;Educational Curriculum;Educational process of instructing;Elements;Ensure;Environment;Epidemiologist;Epidemiology;Exercise;experience;Exposure to;Faculty;follow-up;Foundations;Framingham Heart Study;Future;genetic analysis;Genomics;graduate school;graduate student;health disparity;health inequalities;High Performance Computing;Home;Industry;infectious disease model;inferential statistics;Infrastructure;innovation;Institution;interest;Jackson Heart Study;Knowledge;Learning;lectures;Life;Linux;Machine Learning;Mentors;National Heart, Lung, and Blood Institute;National Institute of Allergy and Infectious Disease;Occupations;Output;Participant;Physicians;Program Effectiveness;programs;Public Health;Reproducibility;Research;Research Project Grants;residence;Role;Running;Schedule;Scholarship;Scientist;Site Visit;skills;Solid;Statistical Computing;Statistical Data Interpretation;Statistical Models;Structure;student participation;Students;summer institute;Surveys;Taste Perception;teaching assistant;tool;trend;Tuberculosis;undergraduate student;Universities;Update;virtual;Vocational Guidance;Work

PROJECT_TITLE: BU Summer Institute for Research Education in Biostatistics and Data Science


NIH_SPENDING_CATS: Cardiovascular;Contraception/Reproduction;Genetics;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Women's Health Research

ORG_CITY: Loma Linda

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: LOMA LINDA UNIVERSITY

PHR: Program Narrative Pregnancy is associated with a striking increase of uterine blood flow that is essential for normal fetal development as well as for cardiovascular well-being of the mother. Hypoxia during pregnancy has profound adverse effects on uterine artery hemodynamics adaptation, increasing incidence of pregnancy complications of preeclampsia and fetal intrauterine growth restriction. Yet, much remains unknown of the mechanisms underlying maternal cardiovascular adaptation to chronic hypoxia during pregnancy. Scientifically, the proposed study will augment our understanding of basic mechanisms whereby maternal cardiovascular system adapts to pregnancy and gestational hypoxia. From a clinical standpoint, the study will provide new insights and suggest new directions in the management of pregnancy complications and abnormal fetal development associated with gestational hypoxia, thereby reducing perinatal morbidity and mortality while improving maternal health and neonatal outcome.

PI_NAMEs: BLOOD, ARLIN B;ZHANG, LUBO  (contact)

PROGRAM_OFFICER_NAME: VARAGIC, JASMINA

PROJECT_TERMS: Acclimatization;Adverse effects;Altitude;Animal Model;Arteries;Binding;Blood flow;Blood Pressure;Blood Vessels;Cardiac Myocytes;Cardiovascular system;Chronic;Clinical;Communication;Down-Regulation;Epigenetic Process;Estrogens;Exposure to;fetal;Fetal Development;Fetal Growth Retardation;Functional disorder;Gene Expression;Gene Expression Regulation;Genes;gestational hypoxia;Gonadal Steroid Hormones;hemodynamics;Human;Hypoxia;improved;in vivo;Incidence;insight;interest;knock-down;L-type calcium channel alpha(1C);Maternal Health;Measurement;Mediating;Methylation;MicroRNAs;Mitochondria;Molecular;Monomeric GTP-Binding Proteins;Mothers;Muscle Contraction;neonatal outcome;novel;Organ;Pathway interactions;perinatal morbidity;Perinatal mortality demographics;Personal Satisfaction;pharmacologic;Phenotype;Physiology;Play;Pre-Eclampsia;Pregnancy;Pregnancy Complications;Pregnant sheep;Pregnant Women;pressure;Production;programs;promoter;protein expression;Quantitative Reverse Transcriptase PCR;Regulation;Research;Resistance;response;Response Elements;Role;RRAD gene;Sea;Sheep;Systemic blood pressure;Testing;transcriptome sequencing;Translations;Up-Regulation;Uterus;vascular bed;Vascular resistance;Vascular Smooth Muscle;vasoconstriction;virtual

PROJECT_TITLE: Mechanisms of uterine artery hemodynamics adaptation to pregnancy and gestational hypoxia

STUDY_SECTION: PN

STUDY_SECTION_NAME: Pregnancy and Neonatology Study Section[PN]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biotechnology;Brain Disorders;Drug Abuse (NIDA only);Genetics;Human Genome;Neurosciences;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: PHILADELPHIA

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE A necessary step in the development of improved OUD therapeutics is to understand the architecture and function of endogenous opioid receptor-expressing neural circuits in the brain. Despite extensive research, how these circuits maintain cellular dependence and drive brain-wide maladaptive plasticity across different stages of the addiction cycle is unclear. To address these gaps, we will map the global cell-type identity, shifting connectivity, and ensemble activity of the opioidergic networks throughout various stages of addiction. Our team-driven project will create an integrated, rapidly searchable database to be mined by other researchers to accelerate the pace of OUD research and future development of new OUD treatments.

PI_NAMEs: BASSETT, DANIELLE SMITH;BEIER, KEVIN T;BLENDY, JULIE A;CORDER, GREGORY  (contact)

PROGRAM_OFFICER_NAME: SATTERLEE, JOHN S

PROJECT_TERMS: 3-Dimensional;Abstinence;Acceleration;Acute;addiction;Address;Adopted;Amygdaloid structure;Anatomy;Anterior;Architecture;Atlases;Axon;Behavior;behavior measurement;Brain;brain cell;Brain region;cell type;Cells;Characteristics;Chronic;cingulate cortex;Classification;control theory;Coupled;Data Set;Databases;Dependence;Development;Drug usage;endogenous opioids;Epidemic;Equilibrium;Evolution;experimental study;Future;Gene Expression;gene network;Genes;Genetic;Genetic Transcription;Genomics;Graph;Head;high throughput screening;Image;improved;In Situ Hybridization;Incidence;innovation;Label;Lifestyle-related condition;Link;Machine Learning;Maintenance;Maps;mathematical model;Measurement;Methods;Microscope;midbrain central gray substance;Modeling;mu opioid receptors;neural;neural circuit;neural network;neuroadaptation;Neuroanatomy;neuroimaging;Neurons;next generation;novel;Nucleus Accumbens;Opiate Addiction;Opioid;opioid exposure;Opioid Peptide;Opioid Receptor;opioid use disorder;opioid withdrawal;Output;Pathologic;Pharmaceutical Preparations;Population;Process;Relapse;Research;Research Personnel;Resolution;response;Role;Sampling;searchable database;single nucleus RNA-sequencing;Site;System;Technology;theories;Therapeutic;Time;Tissues;transcriptomics;Ventral Tegmental Area;virus genetics;Visualization;Withdrawal

PROJECT_TITLE: Circuitry dynamics underlying opioid-dependence: Integrating structural, functional, and transcriptomic mechanisms


ADMINISTERING_IC: DE

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Dental, Oral, and Craniofacial Disease;Regenerative Medicine;Transplantation

ORG_CITY: Lowell

ORG_NAME: REVBIO, INC.

PHR: PROJECT NARRATIVE At least 50% of US adults over the age of 45 have missing teeth; however, over 70% of patients must first undergo a ridge augmentation procedure to provide adequate bony structure to accept implant placement. Most dentists remain dissatisfied with existing bone grafts due to their challenging handling properties and poor predictability that often require a secondary augmentation procedure. The proposed project aims to demonstrate through translational animal testing how a novel regenerative bone adhesive scaffold can accelerate volume preserving bone regeneration in patients seeking treatment with residual ridge resorption.

PI_NAMEs: JADIA, RAHUL  (contact);KAY, GEORGE

PROGRAM_OFFICER_NAME: LOPEZ, ORLANDO

PROJECT_TERMS: Acceleration;Address;Adhesives;Adult;Adverse effects;Age;allogenic bone transplantation;Allografting;Alveolar;Animal Testing;Animals;Applications Grants;Area;Atrophic;Bilateral;Biocompatible Materials;Biological;biomechanical test;Blood;Blood Chemical Analysis;Blood coagulation;bone;bone preservation;Bone Regeneration;bone scaffold;Bone Substitutes;Bone Transplantation;Breakthrough device;canine model;Canis familiaris;Clinical;cohort;Containment;cost;Crowns;Cytoplasmic Granules;Data;Defect;Dental;dental adhesive;Dental Implants;Dentists;design;Development;Devices;Drug Kinetics;Edentulous Mouth;efficacy study;Ensure;Evaluation Studies;Feedback;Femur;Funding;Growth;Height;Histologic;Human;Implant;implantation;Implantation procedure;improved;In Vitro;Injections;Jaw;Maintenance;Mandible;Market Research;Marketing;meetings;Membrane;Michigan;migration;Minerals;Mission;Modeling;New Zealand;notch protein;novel;Operative Surgical Procedures;Organ Transplantation;Oryctolagus cuniculus;Outcome;Outcome Measure;Particulate;Patients;Performance;Pharmaceutical Preparations;Pharmacodynamics;pharmacokinetics and pharmacodynamics;Phase;phase 2 study;Phosphoserine;Plasma;Porosity;preservation;prevent;Procedures;Process;Property;regenerative;Regenerative Medicine;Regulatory Pathway;Residual state;Resources;Safety;Saline;sample fixation;scaffold;Serine;sham surgery;soft tissue;standard of care;Structure;Surface;Surgeon;tetracalcium phosphate;Time;Tissues;Tooth Loss;Tooth structure;United States National Institutes of Health;Width;X-Ray Computed Tomography

PROJECT_TITLE: Development of a Novel Bone Adhesive Scaffold to Accelerate Bone Regeneration and Improve Ridge Height Maintenance for the Treatment of Patients with Residual Ridge Resorption


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Genetics;Pediatric

ORG_CITY: SAN FRANCISCO

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE PUBLIC HEALTH RELEVANCE: Defects in cranial neural crest development lead to a variety of craniofacial diseases and malformations affecting the face, e.g. Treacher Collins syndrome, DiGeorge syndrome, and cleft palate to name a few. In this project, I will investigate the regulation and mechanism of function of the secreted protein Draxin, which will significantly enhance our understanding of the regulation of cranial neural crest delamination and migration, providing new scientific avenues for translational research applications in the treatment of craniofacial defects.

PI_NAMEs: HUTCHINS, ERICA  (contact)

PROGRAM_OFFICER_NAME: SAIFUDEEN, ZUBAIDA

PROJECT_TERMS: Affect;antagonist;beta catenin;Binding;Biochemistry;Bioinformatics;Biological Assay;Cadherins;Cartilage;Cell Adhesion;Cell Adhesion Molecules;Cell-Cell Adhesion;Central Nervous System;Cephalic;Chick;ChIP-seq;Cleft Palate;Co-Immunoprecipitations;craniofacial;Craniofacial Abnormalities;craniofacial structure;Data;Defect;Development;DiGeorge Syndrome;Disease;Down-Regulation;E-Cadherin;Embryo;Embryology;epithelial to mesenchymal transition;Etiology;Event;experimental study;Extracellular Matrix Proteins;Face;Fluorescence Resonance Energy Transfer;Gelatinase B;Gene Expression;Genomic Segment;Goals;Head;Image;Immunoprecipitation;In Situ Hybridization;in vivo;Integrins;knock-down;Laminin;laminin alpha5;Lead;Ligation;Light;Maintenance;malformation;Mandibulofacial Dysostosis;Mediating;Mentors;Messenger RNA;Microscopy;migration;Molecular;mRNA Expression;Mutate;Mutation;N-Cadherin;Names;Neural Crest;Neural Crest Cell;neural plate;Neural tube;neuroepithelium;overexpression;Pathway interactions;Phase;Play;Population;Post-Transcriptional Regulation;posttranscriptional;Protein Secretion;Proteins;public health relevance;receptor;Regulation;Reporter;Research;RNA;RNA-Binding Proteins;Role;sensor;Site;Skeleton;Snails;spatiotemporal;stem cell population;Tail;Techniques;Time;Translational Research;Untranslated Regions;Up-Regulation;WNT Signaling Pathway

PROJECT_TITLE: Characterization of the roles and regulation of Draxin in cranial neural crest


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

PHR: NARRATIVE The control of energy balance depends on the interplay of a myriad of central and peripheral signals that ultimately lead to the maintenance of energetic homeostasis. Lately, the reproductive neurotransmitter kisspeptin, produced in Kiss1 neurons, has emerged as a novel metabolic signal although its mechanism of action remains ill-defined. We have observed that Kiss1 neurons mediate the regulation of energy expenditure exerted by melanocortins, therefore, understanding the neuroanatomical underpinnings of the melanocortin-kisspeptin action on energy balance is the overarching goal of this proposal.

PI_NAMEs: NAVARRO, VICTOR MANUEL (contact)

PROGRAM_OFFICER_NAME: COOKE, BRAD

PROJECT_TERMS: Ablation;Animal Model;Binding;Body Weight;Brown Fat;Carbon Dioxide;CASP3 gene;Chronic;Clustered Regularly Interspaced Short Palindromic Repeats;Consumption;Cues;Data;Dependovirus;Development;Eating;energy balance;Energy Metabolism;Ensure;Evaluation;Excision;Expenditure;Female;Fertility;Food Energy;Genetic;Glutamates;Goals;Gonadal Steroid Hormones;High Fat Diet;Homeostasis;Hypogonadism;Hypothalamic structure;improved;Induced Neurons;insight;Investigation;KISS1 gene;knock-down;Knock-in;Knockout Mice;Label;leptin receptor;Link;Maintenance;male;Maps;Mediating;Mediator;Melanocortin 4 Receptor;men;Menopause;Metabolic;Metabolic Diseases;metabolic phenotype;Metabolism;Mus;neural circuit;Neural Pathways;Neuroanatomy;Neurokinin B;neuromechanism;Neurons;Neuropeptides;Neurotransmitters;Nodal;novel;Obesity;optogenetics;Organism;paraventricular nucleus;Pathway interactions;Patients;Peripheral;Phenotype;Physiological;Play;Polycystic Ovary Syndrome;Postmenopause;postsynaptic;postsynaptic neurons;Pregnancy;preservation;Pro-Opiomelanocortin;Production;receptor;Regulation;Regulatory Pathway;Reproduction;reproductive;reproductive axis;reproductive function;restoration;Role;Satiation;Signal Transduction;Site;Testing;Testosterone;Thermogenesis;transmission process;Weight Gain;Woman;α-Melanocyte stimulating hormone

PROJECT_TITLE: Characterization of Kiss1 neurons as mediators of the reproductive regulation of energy balance

STUDY_SECTION: BNRS

STUDY_SECTION_NAME: Behavioral Neuroendocrinology, Neuroimmunology, Rhythms, and Sleep Study Section [BNRS]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Clinical Trials and Supportive Activities;Immunotherapy

ORG_CITY: DAVIS

ORG_DEPT: DERMATOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: PROJECT NARRATIVE This proposal will provide Dr. Maverakis support to continue to mentor young clinical investigators from various backgrounds in patient-oriented research, especially on projects involving “omic” datasets. Dr. Maverakis' research is focused on using genetic and glycomic datasets to construct diagnostic and predictive classifiers to identify patients who will: experience a progression in disease severity, respond to a particular therapy, or develop an associated disease. In addition, Dr. Maverakis proposes to augment his current patient- oriented-research by designing and conducting early stage clinical studies to explore novel treatments and their biomechanisms.

PI_NAMEs: MAVERAKIS, EMANUAL M. (contact)

PROGRAM_OFFICER_NAME: UNDALE, ANITA H

PROJECT_TERMS: Academy;Age;Age Years;Ancillary Study;Asthma;Autoimmune Diseases;Autoimmunity;Award;B-Lymphocytes;Big Data Methods;Biological Markers;Cancer Patient;Cells;Charge;Clinical;clinical application;Clinical Investigator;Clinical Research;clinical training;Clinical Trials;clinically relevant;Culture Media;cytokine;Data;Data Set;Development;Diagnostic;Disease;Dissociation;Distant;Dose;Double-Blind Method;Educational process of instructing;Ensure;Etiology;experience;feeding;Female;Functional disorder;Future;Galactose;Gender;Genetic;Glycobiology;Glycocalyx;Glycoconjugates;Glycopeptides;Glycoproteins;glycosylation;Goals;Human;human disease;Hypersensitivity;IgE;Immunogenetics;Immunoglobulin G;Immunologic Monitoring;Immunologics;Immunotherapy;improved;Individual;Inflammatory;Institution;instrumentation;interest;Isomerism;Laboratories;Libraries;Lipids;Liquid Chromatography;male;Maps;Measures;Mediating;Mentors;Methodology;Methods;Mid-Career Clinical Scientist Award (K24);Monitor;monomer;multiple reaction monitoring;National Research Council;novel;Nucleic Acids;Oral;Organism;Pathogenicity;patient oriented research;Patients;Pattern;phase 1 study;Phase I Clinical Trials;Physicians;Pilot Projects;Placebo Control;Plasma;Play;Polysaccharides;Prediction of Response to Therapy;Procedures;prognostic;Proteins;Protocols documentation;Randomized;Research;Research Design;Resource Sharing;Rheumatoid Arthritis;Role;Sampling;Scientist;Serum;Severity of illness;Site;Technology;technology development;Therapeutic;Time;Training;Translating;translational scientist;United States National Institutes of Health

PROJECT_TITLE: Mentoring Translational Scientists in Clinical Trial Immune Monitoring

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: Nashville

ORG_DEPT: PHARMACOLOGY

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: Project Narrative Funds provide for students to receive training in the discipline of Pharmacology. Training includes both coursework and mentored research. Scientists trained in this area perform important jobs in drug development in universities and industries, product safety, and regulatory affairs.

PI_NAMEs: IVERSON, T M (contact);KAVALALI, EGE T

PROGRAM_OFFICER_NAME: BLATCH, SYDELLA ANNE

PROJECT_TERMS: pharmacologic;Science;Training

PROJECT_TITLE: Training in Pharmacological Sciences

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - B[TWD-B]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Chronic Pain;Clinical Research;Neurosciences;Pain Research;Rehabilitation

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative This study seeks to better understand chronic pain in older adults by conducting a national survey of adults >65 years of age. The survey will determine the prevalence of chronic pain, describe the nature of chronic pain, and examine what biological, psychological and social factors contribute to chronic pain in older adults. The survey will compare those with and without chronic pain and describe over 12 months how chronic pain affects physical function, cognitive function and quality of life.

PI_NAMEs: MIASKOWSKI, CHRISTINE A.;RITCHIE, CHRISTINE S (contact)

PROGRAM_OFFICER_NAME: BAKOS, ALEXIS DIANE

PROJECT_TERMS: Acetaminophen;Adult;Adverse effects;Affect;Age;Age Reporting;Age Years;Ageism;American;Anxiety;Awareness;Biological;Biological Factors;Cardiovascular system;Characteristics;Chronic;Chronic Obstructive Pulmonary Disease;chronic pain;chronic pain management;cognitive function;comorbidity;Complex;Data;Diabetes Mellitus;effective intervention;Effectiveness;Enrollment;Environment;epidemiology study;experience;Future;gastrointestinal;Goals;Growth;Guidelines;Heart failure;human old age (65+);improved;improved outcome;Intervention;Investigation;Knowledge;Location;Longitudinal Studies;Medical;Mental Depression;Methodology;multiple chronic conditions;Nature;Non-Steroidal Anti-Inflammatory Agents;Nonpharmacologic Therapy;older adult;older patient;Opioid;Opioid Analgesics;opioid therapy;Outcome;overdose death;Pain;Pain management;pain score;Patient Outcomes Assessments;Patient-Focused Outcomes;Persistent pain;person centered;pharmacologic;Pharmacological Treatment;Physical Function;Policies;Population;Population Research;Population Study;population survey;prescription opioid;Prevalence;psychologic;Psychological Factors;Quality of life;Recommendation;Reporting;Research;Sampling;Severities;sex;side effect;Site;social;social factors;social stigma;Social support;Special Population;Stress;Subgroup;Surveys;Testing;United States;virtual

PROJECT_TITLE: Characteristics and impact of chronic pain and pain management in older adults

STUDY_SECTION: CMPC

STUDY_SECTION_NAME: Clinical Management of Patients in Community-based Settings Study Section[CMPC]


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Patient Safety;Precision Medicine;Racial and Ethnic Minority Health Research

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: Project Narrative The Texas Experimental Cancer Therapeutic Network (TEX-CTN) will leverage the strengths of  the four UT institutions, to rationally design individualized novel cancer therapeutics through  testing within molecularly profiled populations, integrating pharmacodynamic markers in early  clinical trials, and programmatic assessment of predictors of intrinsic sensitivity/resistance and  mechanisms of acquired resistance. The TEX-CTN also is uniquely positioned to offer  participation to patients who have been traditionally underrepresented in innovative early phase  clinical trials.

PI_NAMEs: CAPASSO, ANNA ;KLIMBERG, VICKI SUZANNE;MERIC-BERNSTAM, FUNDA  (contact);SARANTOPOULOS, JOHN ;YAO, JAMES C

PROGRAM_OFFICER_NAME: IVY, S PERCY

PROJECT_TERMS: Advanced Development;Adverse event;Authorship;Biochemical;Biological;biomarker driven;Biopsy;Cancer Center;cancer health disparity;carcinogenesis;circulating biomarkers;circulating DNA;Clinic;Clinical;clinical practice;Clinical Research;Clinical Trials;Clinical Trials Design;Clinical Trials Network;clinically relevant;Collaborations;Common Neoplasm;Critical Pathways;cytokine;Data;Development;Diagnostic;Disease;DNA;Dose;Dose Limiting;early phase clinical trial;early-career faculty;Enrollment;Ensure;Environment;Ethnic Population;Explosion;Faculty;Goals;Hair follicle structure;Health;Human;Image;imaging modality;Immune;innovation;Institution;International;Intervention;Investigational Therapies;Joints;Lead;Leadership;Malignant Neoplasms;Medical;meetings;member;Mentors;Minority Groups;Molecular;Molecular Abnormality;Molecular Analysis;Molecular Profiling;multidisciplinary;Neoplasm Circulating Cells;New Agents;novel;novel marker;novel therapeutics;Oncology;Organizational Affiliation;Pathologic;Pathologist;patient derived xenograft model;Patients;Peripheral Blood Mononuclear Cell;Pharmaceutical Preparations;pharmacodynamic biomarker;Pharmacodynamics;pharmacokinetics and pharmacodynamics;Phase;Population;Positioning Attribute;pre-clinical;precision oncology;predicting response;predictive marker;Process;prospective;Proteins;protocol development;Protocols documentation;Publications;Qualifying;racial population;radiologist;rational design;Reporting;Research Design;Research Personnel;Resistance;response;response biomarker;RNA;Rural Population;Safety;safety study;Sampling;Schedule;Skin;Specimen;targeted agent;Technology;Testing;Texas;Therapeutic;Therapeutic Agents;Therapeutic Clinical Trial;Therapeutic Uses;Tissues;Translating;translational scientist;tumor;Tumor Markers;underserved minority;Universities;University of Texas M D Anderson Cancer Center

PROJECT_TITLE: Texas EXperimental Cancer Therapeutics Network - TEX CTN


NIH_SPENDING_CATS: Chronic Obstructive Pulmonary Disease;Emphysema;Genetics;Lung;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE Chronic obstructive pulmonary disease (COPD) is a prevalent and progressive obstructive lung disease caused by cigarette smoke exposure with few effective therapies. The role of mitochondrial dysfunction and cellular senescence, a state of cell arrest, in COPD pathogenesis remain unknown and an area of high scientific interest. This work will define how adenine nucleotide translocase (ANT2), a mitochondrial ADP/ATP translocase, influences mitochondrial dysfunction that drives cellular senescence and abnormal repair of the lung epithelium, thus opening the potential for ANT as a therapeutic target for COPD.

PI_NAMEs: KLIMENT, CORRINE R (contact)

PROGRAM_OFFICER_NAME: LU, QING

PROJECT_TERMS: Abnormal Epithelial Cell;Adenine Nucleotide Translocase;airway obstruction;Alveolar;alveolar epithelium;Antioxidants;Area;Automobile Driving;bronchial epithelium;Cause of Death;Cell Aging;Cell Cycle Arrest;Cell Line;Cell Physiology;Cells;Cellular Metabolic Process;Chronic;Chronic Obstructive Pulmonary Disease;cigarette smoke;Data;Disease Progression;DNA Damage;effective therapy;Epithelial Cells;epithelial repair;Equilibrium;Excision;exposure to cigarette smoke;gain of function;Gene Expression;Genus Hippocampus;Goals;Homeostasis;Human;improved;In Vitro;in vivo;in vivo Model;Inflammation;inhibitor;Injury;insight;interest;knock-down;Knock-out;Knockout Mice;Knowledge;loss of function;Lung;Lung Diseases;lung repair;Mediating;Metabolic;Metabolism;Mitochondria;mitochondrial dysfunction;mitochondrial metabolism;Modeling;mouse model;Mus;NADH;novel;novel therapeutic intervention;Obstructive Lung Diseases;oncoprotein p21;Organoids;Outcome;Oxidation-Reduction;Pathogenesis;Pathway interactions;Patients;Pharmaceutical Preparations;prevent;Process;Production;progenitor;programs;Proliferating;Pulmonary Emphysema;Reactive Oxygen Species;repaired;Respiration;response;restoration;Role;senescence;senescence associated secretory phenotype;senescent cell;senolytics;Slice;stem cell function;stem cells;Structure of parenchyma of lung;Testing;Therapeutic;therapeutic development;therapeutic target;Tissues;Transcriptional Regulation;United States;Work

PROJECT_TITLE: The Role of Adenine Nucleotide Translocase in Mitochondrial Dysfunction Associated Senescence in Chronic Obstructive Pulmonary Disease (COPD)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CVRS-B(03)]


ORG_CITY: LA JOLLA

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: In cancer, tumor inflammation plays a multifaceted role in disease progression and response to therapies. The ability to non-invasively image tumor inflammation would greatly enhance our ability to stratify patients for treatments. This project will develop and characterize novel diagnostic imaging radiopharmaceutical agents that enable sensitive and precise quantification of tumor inflammation in vivo.

PI_NAMEs: AHRENS, ERIC T. (contact)

PROGRAM_OFFICER_NAME: TANDON, PUSHPA

PROJECT_TERMS: 3-Dimensional;acute infection;angiogenesis;Animals;anti-cancer therapeutic;Antitumor Response;Autoimmune Diseases;Biological;Biological Assay;bioluminescence imaging;Blood;Breast;cancer clinical trial;Cancer Detection;cancer imaging;Cancer Model;Cations;Cells;Cellular Assay;chelation;clinical translation;Clinical Trials;Complex;Data;Detection;detection sensitivity;Diagnostic;diagnostic biomarker;Diagnostic Imaging;Disease;Disease Progression;Dissociation;Dose;dosimetry;Effectiveness;Encapsulated;Exclusion;Flow Cytometry;Fluorocarbons;Formulation;Future;Growth;Half-Life;Head and Neck Cancer;Hydrophobicity;Image;imaging biomarker;imaging probe;imaging study;Immune checkpoint inhibitor;Immunooncology;Immunosuppression;Immunotherapeutic agent;Immunotherapy;improved;In Vitro;in vivo;Incidence Study;Inflammation;Inflammatory;Intervention;Intravenous;intravenous injection;Label;Laboratories;Lipids;Macrophage;Malignant Neoplasms;Measurement;Metals;Methods;Modeling;Molecular Probes;mouse model;Mus;nanoemulsion;Nature;Neoplasm Metastasis;Non-Invasive Detection;non-invasive imaging;novel;novel diagnostics;Oils;patient stratification;personalized medicine;Phagocytes;Phase;Phenotype;Play;Positron-Emission Tomography;pre-clinical;preclinical study;predicting response;Prediction of Response to Therapy;predictive marker;Prognosis;Proteins;Radiochemistry;Radiopharmaceuticals;Reproducibility;Residual state;response;Reticuloendothelial System;Rodent;Rodent Model;Role;scale up;Signal Transduction;Site;Solid Neoplasm;Surface;Suspensions;targeted treatment;Technology;Therapeutic;therapy resistant;Toxic effect;translational potential;Treatment Efficacy;treatment response;tumor;Tumor Markers;tumor microenvironment;Tumor-associated macrophages;Vesicle;Water;Zirconium

PROJECT_TITLE: Metallo-fluorocarbon nanoemulsion for PET detection of cancer inflammation

STUDY_SECTION: IPCA

STUDY_SECTION_NAME: Imaging Probes and Contrast Agents Study Section[IPCA]


NIH_SPENDING_CATS: Diabetes;Nutrition

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Novel Metabolic Actions of GIP Project Narrative:  The incretin system is strategically positioned to control metabolism in the postprandial state and people with type 2 diabetes have severe impairments in the incretin axis. Heretofore, the incretin system has been viewed primarily within a glucose context and incretin action has been studied almost exclusively in b-cells. Our preliminary data demonstrates that a-cells and glucagon are significant contributors to the incretin axis and that GIP is a crucial determinant of this novel mechanism.

PI_NAMEs: CAMPBELL, JONATHAN E (contact);D'ALESSIO, DAVID A.

PROGRAM_OFFICER_NAME: HWA, ALBERT J

PROJECT_TERMS: Agonist;Alanine;Alpha Cell;Amino Acids;Anabolism;analog;antagonist;Anti-diabetic Drugs;Area;Automobile Driving;B-Lymphocytes;Beta Cell;Binding;blood glucose regulation;Cell Communication;Cell Physiology;Cell secretion;Cells;Communication;Compensation;Coupled;Cyclic AMP;Data;diabetic;Diet;Disease;Eating;Equilibrium;Fatty acid glycerol esters;Fatty Acids;feeding;Functional disorder;Gases;Gastric Inhibitory Polypeptide;gastric inhibitory polypeptide receptor;Generations;GLP-I receptor;Glucagon;glucagon-like peptide;glucagon-like peptide 1;Glucose;Glucose Intolerance;glucose production;glucose tolerance;Goals;Homeostasis;Hormones;Human;human data;Hyperglycemia;Hypoglycemia;impaired glucose tolerance;Impairment;in vivo;Individual;insight;Insulin;insulin secretion;Intervention;Intestines;islet;Knock-out;Knockout Mice;Link;Macronutrients Nutrition;Measures;Mediating;Medicine;Metabolic;Metabolic stress;Metabolism;Modeling;Mus;Non-Insulin-Dependent Diabetes Mellitus;novel;Nutrient;nutrient metabolism;Patients;Peptides;Persons;Pharmaceutical Preparations;pharmacologic;Phenotype;Physiological;Physiology;Plasma;Play;Positioning Attribute;Postabsorptive Hypoglycemia;preclinical study;prevent;primary endpoint;Production;proglucagon;receptor;Receptor Signaling;Regulation;response;Rodent;Role;Signal Transduction;Specificity;Stimulus;synergism;System;Testing;Thinking;Time;Work

PROJECT_TITLE: Novel metabolic actions of GIP

STUDY_SECTION: IPOD

STUDY_SECTION_NAME: Integrative Physiology of Obesity and Diabetes Study Section[IPOD]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Acute Respiratory Distress Syndrome;Behavioral and Social Science;Brain Disorders;Clinical Research;Hematology;Infectious Diseases;Lung;Mental Health;Neurosciences;Rare Diseases;Sepsis

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative The Acute Respiratory Distress Syndrome (ARDS), a form of critical illness characterized by lung inflammation and severe hypoxia, is common and frequently leads to delirium. This proposal seeks to understand how fragments of sugars are released into the bloodstream from the blood vessels of the lung during ARDS and how these sugars cause hyperactivity of the brain during ARDS. It will then determine if brain hyperactivity caused by these sugars plays a role in delirium during ARDS.

PI_NAMEs: HIPPENSTEEL, JOSEPH ALAN (contact)

PROGRAM_OFFICER_NAME: KALANTARI, ROYA

PROJECT_TERMS: Acids;Acute;Acute Respiratory Distress Syndrome;analog;Award;behavior measurement;Behavioral Assay;Benzodiazepines;Beta-glucuronidase;Biology;Blood Circulation;Blood Vessels;Brain;Brain region;career;Cells;Cessation of life;Chemosensitization;Chondroitin ABC Lyase;Chondroitin Sulfate A;Chondroitin Sulfates;Circulation;Clinical;clinically relevant;clinically significant;cohort;Conscious;Critical Illness;Data;Dedications;Delirium;Early Mobilizations;Electroencephalography;Electrophysiology (science);Endothelial Cells;Endothelium;Endotoxemia;Excision;experimental study;Extravasation;Fostering;Functional disorder;Funding;Future;Glycocalyx;Glycosaminoglycans;heparanase;Heparitin Sulfate;Hippocampus;Homeostasis;Human;Hyperactivity;Hypoxemia;Hypoxia;Impaired cognition;in vivo;in vivo Model;Inflammatory;inhibitor;Intervention;Invaded;Investigation;Investments;Ion Channel;Knockout Mice;Laboratories;Long term disability;Lung;lung injury;Mass Spectrum Analysis;Mediating;Mediator;Modeling;Modification;mouse model;Mus;neuronal excitability;Neurons;novel;Outcome;Pathogenesis;Patients;Penetration;Perfusion;Pharmaceutical Preparations;pharmacologic;Physicians;Physiology;Plasma;Pre-Clinical Model;Preparation;Pulmonary Inflammation;receptor;Regional Perfusion;Research;response;Risk;Scientific Advances and Accomplishments;Scientist;Sepsis;Slice;Source;success;sugar;Sulfate;Survivors;System;targeted treatment;Technical Expertise;Techniques;Time;translational study;Up-Regulation;vascular bed;Viral Pneumonia;Whole Organism;Work

PROJECT_TITLE: Lung-Brain Axis as a Mediator of Delirium

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(MA)]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Breast Cancer;Cancer;Clinical Research;HIV/AIDS;Infectious Diseases;Patient Safety;Precision Medicine;Women's Health Research

ORG_CITY: PARKTOWN

ORG_COUNTRY: SOUTH AFRICA

ORG_FIPS: SF

ORG_NAME: WITS HEALTH CONSORTIUM (PTY), LTD

PHR: PROJECT NARRATIVE Title: Novel predictors of survival among breast cancer patients with/without HIV in South Africa Breast cancer incidence and mortality rates of breast cancer are rising in regions with high HIV prevalence. No prior large-scale multicenter, multiethnic prospective study has evaluated the impacts of HIV and ART on breast cancer outcomes in sub-Saharan Africa. These analyses will contribute to the development of evidence-based guidelines for breast cancer management among women with HIV and will yield new insights into both HIV and breast cancer

PI_NAMEs: CUBASCH, HERBERT ;EL-SADR, WAFAA M.;JACOBSON, JUDITH S;JOFFE, MAUREEN  (contact);NEUGUT, ALFRED I.;RUFF, PAUL

PROGRAM_OFFICER_NAME: DOMINGUEZ, GERALDINA

PROJECT_TERMS: Academic Medical Centers;Achievement;Address;Adherence;adjuvant endocrine therapy;Affect;Africa South of the Sahara;African ancestry;African Women;Age;antiretroviral therapy;black women;Blood specimen;Breast;breast cancer diagnosis;Breast Cancer Patient;breast cancer survival;Breast Cancer Treatment;Budgets;Cancer Etiology;cancer health disparity;Cancer Patient;cancer therapy;Carcinoma;Cessation of life;Characteristics;chemotherapy;Chemotherapy-Oncologic Procedure;Chronic;Clinic;Clinical;cohort;Collaborations;comorbidity;Contracts;CYP2D6 gene;Data;Death Rate;Development;Diagnosis;Disease;doctoral student;Dose;Drug Interactions;Drug Kinetics;Enrollment;Enzyme Inhibition;Enzymes;epidemiology study;evidence based guidelines;Female;Funding;gene interaction;Genetic Polymorphism;Genotype;Good Clinical Practice;Grant;HIV;HIV Infections;HIV Seronegativity;HIV Seropositivity;hormone therapy;Hospitals;human old age (65+);improved;Incidence;Individual;Informed Consent;insight;lectures;Life Expectancy;Link;Liver;low and middle-income countries;Malignant Breast Neoplasm;Malignant Neoplasms;Mediator;Mentors;Metabolism;middle age;Modality;Monitor;mortality;Mortality Determinants;multi-ethnic;Natural History;neighborhood disadvantage;Newly Diagnosed;novel;Oral;Outcome;Outcome Study;Patient Compliance;Patient Self-Report;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;Pharmacogenomics;Plasma;Polypharmacy;Postdoctoral Fellow;Predisposition;premature;Preparation;Prevalence;Prognosis;Prospective Studies;Publications;recruit;Reporting;Research Ethics;Research Personnel;Resources;sarcopenia;Serum;sociodemographics;South Africa;South African;Specimen;Standardization;Students;Surrogate Markers;Surveys;survival prediction;Survival Rate;Tamoxifen;therapy adherence;Toxic effect;Training;treatment adherence;treatment and outcome;Treatment Efficacy;Universities;Viral Load result;Wit;Woman;Women's mortality;Work;Zimbabwe


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Infectious Diseases;Sexually Transmitted Infections

ORG_NAME: TUFTS UNIVERSITY BOSTON

PHR: Human papillomaviruses multiply when infected epithelial cells undergo differentiation and viral genome synthesis occurs at sites of cellular DNA damage. This proposal investigates how an RNA that does not code for a protein, and which is upregulated during epithelial cell differentiation and induces DNA damage regulates papillomavirus multiplication and if it may serve as a potential antiviral target.

PI_NAMEs: MUNGER, KARL  (contact)

PROGRAM_OFFICER_NAME: ALARCON, RODOLFO M

PROJECT_TERMS: Acute;Address;Area;Biochemical;Biological;cancer cell;Cancer Etiology;Cell Differentiation process;Cell Line;Cell Proliferation;Cells;Cellular biology;cellular targeting;chemotherapy;chronic infection;Code;combat;Country;Data;Development;Disease;DNA Damage;DNA Repair;Ectopic Expression;Episome;Epithelial Cells;Epithelium;experimental study;Genetic Transcription;Genome;Goals;Head and Neck Squamous Cell Carcinoma;Human;Human papilloma virus infection;Human Papillomavirus;Immune response;Incidence;Individual;Infection;insight;keratinocyte;keratinocyte differentiation;Length;Lesion;Life Cycle Stages;loss of function;Maintenance;Malignant - descriptor;Malignant Neoplasms;Marketing;Mediating;Medical;medically underserved;Messenger RNA;Metabolic stress;Molecular;Molecular Biology;mutant;Mutation;Noise;novel;Oral mucous membrane structure;Output;Papillomavirus;Patients;Play;Population;Predisposition;Preventive vaccine;Productivity;Proteins;Publishing;Regulation;Research;response;RNA;Role;Sexually Transmitted Diseases;Signal Transduction;Site;Solid;Stimulus;Structure;Testing;TP53 gene;transcriptome;transcriptome sequencing;transcriptomics;Undifferentiated;Untranslated RNA;Vaccinee;Vaccines;Viral;Viral Genome;Virus

PROJECT_TITLE: Regulation of the Human Papillomavirus Life Cycle by the Long Noncoding RNA DINO

STUDY_SECTION: MCV

STUDY_SECTION_NAME: Molecular and Cellular Biology of Virus Infection Study Section[MCV]


NIH_SPENDING_CATS: Brain Disorders;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

ORG_NAME: BOSTON MEDICAL CENTER

PHR: PROJECT NARRATIVE The CARE Program will make important contributions to the development of the next generation of physician substance use reserachers, educators, and clinicians and to the dissemination of addiction research to address the overdose epidemic. These contributions will health outcomes, especially among adolescents and racial groups whose unhealthy substance use is undertreated, resulting in reduced medical, social, and financial burdens of addiction.

PI_NAMEs: SAMET, JEFFREY H. (contact);WALLEY, ALEXANDER YALE

PROGRAM_OFFICER_NAME: HIGHSMITH, KEISHER S

PROJECT_TERMS: Acute;addiction;Address;Adolescence;Adolescent;Adolescent and Young Adult;Adolescent Medicine;Adult;African American;alcohol misuse;Applications Grants;Boston;career;Caring;Clinical;clinical care;clinical development;Clinical Research;Clinical Skills;clinical training;Collaborations;Communicable Diseases;Community Health;comorbidity;Country;Development;Development Plans;Education;Educational Curriculum;Educational process of instructing;Epidemic;equity, diversity, and inclusion;ethnic disparity;Ethnic Population;evidence base;experience;Exposure to;Faculty;faculty mentor;Financial Hardship;Funding;Gastroenterology;General Practitioners;Goals;Health;health inequalities;Hepatitis C;Hispanic Americans;HIV/HCV;Illicit Drugs;Immersion;improved;Institution;International;Internships;Learning;Medical;Medical center;medical schools;Medical Students;Medicine;Mentors;Mentorship;National Institute of Drug Abuse;Native Americans;next generation;Outcome;Overdose;overdose death;Patient Care;Patients;Physicians;Prevention;programs;racial disparity;racial population;recruit;Research;Research Methodology;Research Personnel;Research Project Grants;research study;Residencies;Risk;Rotation;Scholars Program;Science;screening;Services;skills;social;substance use;Substance Use Disorder;substance use treatment;success;synthetic opioid;Training;Training Programs;Translating;Translational Research;Underrepresented Populations;Update;young adult

PROJECT_TITLE: Clinical Addiction Research and Education (CARE) Program


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);HIV/AIDS;Substance Misuse

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: NARRATIVE The treatment of drug abuse and HIV often requires sequential, individualized decision-making concerning the type or delivery of treatments. The methods developed in this project will enable drug-use and HIV scientists to leverage intensive longitudinal data arising from novel treatment technologies to develop more potent approaches to guide the sequential, individualization of drug use and HIV treatments.

PI_NAMEs: ALMIRALL, DANIEL ;NAHUM-SHANI, INBAL BILLIE (contact)

PROGRAM_OFFICER_NAME: AKLIN, WILL

PROJECT_TERMS: Abstinence;adaptive intervention;Address;Adolescent;AIDS prevention;Behavior;Behavior Therapy;Behavioral Sciences;Clinical;cognitive function;Collection;computerized;contingency management;Data;Data Collection;Data Scientist;Decision Making;design;Development;dosage;Dose;Dropout;Drug abuse;Drug usage;drug use screening;effective intervention;experience;Experimental Designs;Future;Generations;Hand;Health Technology;HIV;improved;Individual;innovation;insight;Intervention;Journals;longitudinal analysis;marijuana use disorder;Measures;Methodology;Methods;Mission;mobile application;Modernization;multidisciplinary;National Institute of Drug Abuse;novel;Observational Study;Outcome;Patients;Peer Review;personalized decision;personalized medicine;Persons;Preparation;Protocols documentation;Public Health;Publishing;Research;Resources;responders and non-responders;response;Rewards;Scientist;Sequential Multiple Assignment Randomized Trial;Short-Term Memory;substance use;Technology;Testing;therapy design;Time;time interval;Training;Treatment Efficacy;trial design;Urinalysis;user friendly software;user-friendly;wearable device;web app;Work

PROJECT_TITLE: Novel Methods for Intensive Longitudinal Data in SMART Studies of Drug Abuse and HIV


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Dissemination and Implementation Research;Health Services;Mental Health;Neurodegenerative;Patient Safety

ORG_CITY: UNIVERSITY PARK

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

PHR: PROJECT NARRATIVE Delirium is common in hospitalized older adults, leads to poor outcomes such as functional and cognitive decline, nursing home placement, and death, yet over half of delirium is unrecognized. Our current Aims will study implementation of daily nurse-led delirium screening using the Ultra-brief Confusion Assessment Method into routine care among all hospitalized older adults. Our findings will directly inform best practices for delirium identification, including in vulnerable individuals such as those with Alzheimer’s Disease and Alzheimer’s Disease Related Dementias.

PI_NAMEs: FICK, DONNA MARIE (contact);MARCANTONIO, EDWARD R

PROGRAM_OFFICER_NAME: NELLISSERY, MAGGIE JACOB

PROJECT_TERMS: 3-Dimensional;Acute;Address;Admission activity;Adopted;Adverse event;Age;Aged, 80 and over;Agitation;Alzheimer's Disease;Alzheimer's disease related dementia;aspirate;Blinded;care providers;Caring;Certification;Cessation of life;clinical care;cognitive function;cohort;Collaborations;Communication;confusion assessment method;Consent;cost;Coupled;decubitus ulcer;Delirium;Diabetes Mellitus;diagnostic tool;Discipline;Discipline of Nursing;Distress;Eligibility Determination;Enrollment;Ethnic Origin;Evaluation;evidence base;falls;Family;field study;Focus Groups;follow-up;Friends;functional decline;future implementation;Goals;Health Care Costs;Healthcare Systems;Heart failure;Home;Hospital complications;Hospitalization;Hospitals;Impaired cognition;implementation design;implementation efforts;implementation facilitators;implementation strategy;improved;improved outcome;Individual;Interview;Length of Stay;Medical;Methods;mortality;Nurses;Nursing Homes;older adult;older patient;Older Population;Operative Surgical Procedures;Outcome;Outcome Assessment;Outcome Measure;Participant;Patient Admission;patient oriented;Patients;Perception;Persons;Pharmaceutical Preparations;Physical Function;Physicians;Progress Reports;prospective;Protocols documentation;Publishing;Qualitative Research;Race;Reference Standards;Registered nurse;Reporting;Research;restraint;routine care;Sampling;screening;Stress;Subgroup;Testing;tool;Translations;trend;Underrepresented Minority;Underrepresented Populations;Vulnerable Populations

PROJECT_TITLE: READI-SET-GO: Researching Efficient Approaches to Delirium Identification - Sustaining Effective Translation to create Gero-friendly Organizations

STUDY_SECTION: ASG

STUDY_SECTION_NAME: Aging Systems and Geriatrics Study Section[ASG]


ORG_CITY: NEW YORK

ORG_DEPT: PATHOLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: PROJECT NARRATIVE Non-responsiveness (i.e., tolerance) to one’s own tissues is essential to prevent autoimmune disease. In some individuals, tolerance breaks down and the immune system destroys one’s own red blood cells; this can be fatal as these cells are required for life. This proposal will identify which pathways and T cell subsets are required for tolerance to one’s own red blood cells, and define how age and sex modify those requirements.

PI_NAMEs: HUDSON, KRYSTALYN E (contact)

PROGRAM_OFFICER_NAME: WELNIAK, LISBETH A

PROJECT_TERMS: Adenosine;Adverse event;Affect;Age;age effect;Age of Onset;Aging;Anemia;Antigens;Autoantibodies;Autoantibody binding;Autoantigens;Autoimmune Diseases;Autoimmune hemolytic anemia;Autoimmunity;Automobile Driving;autoreactive T cell;autoreactivity;Biological Factors;Biological Testing;Blood donor;Blood Platelets;cancer immunotherapy;cancer therapy;CD4 Positive T Lymphocytes;Cells;checkpoint therapy;Clinical;clinically significant;Complication;cytokine;Data;Development;Disproportionately impacts women;ds-DNA;Emigrant;Erythrocyte Transfusion;Erythrocytes;Etiology;Event;experience;extracellular;Failure;Fatigue;Female;Flow Cytometry;Frequencies;Functional disorder;Future;Hematology;Hemoglobinuria;Hemolysis;Hemolysis Induction;Hospitalization;Human;human disease;Idiopathic Thrombocytopenic Purpura;Immune;immune checkpoint;Immune checkpoint inhibitor;Immune response;Immune system;Immune Tolerance;Immunotherapy;Individual;Inflammatory;innovation;insight;Interleukin-10;Knowledge;Life;male;Malignant Neoplasms;Mediating;Medical;Modeling;Morbidity - disease rate;mortality;mouse model;Mus;novel;novel therapeutic intervention;Pallor;Pathogenesis;Pathway interactions;Patients;Platelet Glycoproteins;Population;pre-clinical;Pre-Clinical Model;prevent;Prevention;Production;Publishing;Regulatory T-Lymphocyte;Relapse;Reporting;Research;Reticulocytosis;Risk;Role;Sampling;sex;Signal Pathway;Signal Transduction;Signaling Molecule;Splenomegaly;success;Supportive care;Systemic Lupus Erythematosus;T-Lymphocyte;T-Lymphocyte Subsets;Testing;Thymus Gland;Time;tissue oxygenation;Tissues;transcriptome sequencing;transcriptomics;treatment strategy;virtual

PROJECT_TITLE: Immune Response to RBC Antigens

STUDY_SECTION: HTBT

STUDY_SECTION_NAME: Hemostasis, Thrombosis, Blood Cells and Transfusion Study Section[HTBT]


NIH_SPENDING_CATS: Autoimmune Disease;Cancer;Digestive Diseases;Hematology;Immunotherapy;Infectious Diseases;Inflammatory Bowel Disease;Liver Disease

ORG_CITY: Newark

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: PROJECT NARRATIVE Anemia is a frequent complication of inflammatory diseases marked by dysregulated iron homeostasis. Inflammation-associated anemia is often refractory to treatment, and we lack a basic understanding of how inflammation and anemia influence each other. The focus of this proposal is to define the role of a novel immune-mediated pathway of iron regulation in the course and resolution of diseases involving inflammation.

PI_NAMEs: BESSMAN, NICHOLAS J. (contact)

PROGRAM_OFFICER_NAME: HUDSPETH, KELLY

PROJECT_TERMS: Anemia;Anemia due to Chronic Disorder;Arthritis;Automobile Driving;Biological Markers;Biopsy;Cancer Model;carcinogenesis;Cell Separation;Cells;Chemicals;Chronic Disease;Complication;Crohn's disease;Data;Dendritic Cells;Development;Diabetes Mellitus;Dietary Iron;Disease;Disease Outcome;enteric infection;Epithelium;Erythrocytes;Flow Cytometry;gut inflammation;healing;Health;health determinants;Heart failure;Hemorrhage;hepcidin;Homeostasis;Human;imaging approach;Imaging Techniques;Immune;Immune system;Immune Targeting;immunoregulation;Immunotherapy;in vivo;Infection;Infection Control;Inflammation;Inflammatory;Inflammatory Bowel Diseases;innovation;Intestines;Iron;Iron deficiency anemia;Life;Link;Liver;Liver Cirrhosis;Macrophage;Malignant neoplasm of liver;Malignant Neoplasms;Mammals;Mass Spectrum Analysis;Measures;Mediating;Mediator;Medical;metal transporting protein 1;Modeling;mouse model;Mouse Strains;Mucous Membrane;neutrophil;novel;novel therapeutic intervention;novel therapeutics;Nutritional Immunity;Nutritional Support;Outcome;Pathway interactions;Patients;peptide hormone;Phagocytes;Play;Population;Predisposition;Production;programs;Proteins;Recording of previous events;Recycling;Refractory;Regulation;Research;Research Proposals;Resolution;Role;senescence;Serum;System;targeted treatment;Testing;therapy development;tissue repair;Tissues;tool;tumor;tumor growth;Tumor-infiltrating immune cells;uptake;Work

PROJECT_TITLE: Immune regulation of tissue iron in health and disease


NIH_SPENDING_CATS: Aging;Cardiovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Hypertension;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: Oakland

ORG_NAME: KAISER FOUNDATION RESEARCH INSTITUTE

PHR: Project Narrative About 20% of US young adults have high blood pressure (BP), however, the optimal BP screening and treatment strategies in young adults are unknown. Many young adults are not aware of their high BP, and are not recommended for BP lowering medication, partly due to the lack of evidence. The overall goal of this study is to determine the optimal BP screening intervals and identify subgroups of young adults with high cardiovascular risk who may benefit most from BP lowering medications.

PI_NAMEs: AN, JAEJIN  (contact);ZHANG, YIYI

PROGRAM_OFFICER_NAME: REIS, JARED P

PROJECT_TERMS: Address;Adverse event;African American;Age;aged;Anti-Hypertensive Agents;Blood Pressure;blood pressure control;blood pressure elevation;California;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;cardiovascular risk factor;Characteristics;Chronic Kidney Failure;Clinical;clinically actionable;clinically relevant;cohort;Coronary heart disease;cost;cost effective;cost efficient;Data;Databases;Diabetes Mellitus;Disease Outcome;Early Diagnosis;early onset;Early treatment;economic impact;Electronic Health Record;Epidemiology;Event;evidence base;follow-up;Future;Goals;Guidelines;Health;health inequalities;healthy aging;Heart failure;High Prevalence;high risk;high risk population;Hypertension;hypertension treatment;improved;Intervention;Kidney;late life;Left;Life;Microalbuminuria;Myocardial Infarction;Obesity;Observational Study;older adult;Organ;Outcome;Overweight;Patients;Pharmaceutical Preparations;pharmacologic;Policy Maker;Population;premature;Prevalence;prevent;Productivity;Quality of life;Race;Randomized, Controlled Trials;Recommendation;Research Priority;Risk;Risk Factors;Risk Reduction;screening;screening guidelines;Selection Bias;simulation;social health determinants;Statistical Models;Stroke;Subgroup;Syncope;Time;treatment risk;treatment strategy;United States Preventative Services Task Force;young adult

PROJECT_TITLE: Improving Blood Pressure Screening and Treatment Strategies in Young Adults

STUDY_SECTION: CHSB

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology B Study Section[CHSB]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Infectious Diseases;Rare Diseases

ORG_CITY: SANTA CRUZ

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA SANTA CRUZ

PHR: PROJECT NARRATIVE Surface attached microbial communities, called biofilms, cause significant problems in environmental, industrial, and clinical settings. Vibrio cholerae, which causes the disease cholera, forms biofilms that are critical to its environmental survival, transmission, and infectivity. This research will improve our understanding of biofilm formation and biofilm-mediated hyperinfectivity, define targets to combat this deadly pathogen in both intestinal and aquatic ecosystems, and help develop tools for prediction and control of cholera epidemics.

PI_NAMEs: YILDIZ, HAVVA FITNAT (contact)

PROGRAM_OFFICER_NAME: ZEITUNI, AMIR E

PROJECT_TERMS: 3-Dimensional;Acute Diarrhea;Address;Architecture;Bacteria;Bacterial Adhesins;Binding;Biogenesis;Biological Models;Cells;Chitin;Cholera;Clinical;combat;Communities;design;Development;diarrheal disease;Disease;Disease Outbreaks;Disease Progression;Ecosystem;enteric infection;Environment;Environmental Impact;Epidemic;Extracellular Matrix;Extracellular Protein;Factor V;Gene Cluster;Growth;Habitats;Human;human pathogen;Image;Imaging Techniques;improved;Industrialization;Infant;Infection;Ingestion;inhibitor;insight;interdisciplinary approach;Intervention;intestinal villi;Intestines;Life Style;Lipids;Location;Mediating;Membrane;Membrane Proteins;Microbe;Microbial Biofilms;microbial community;Molecular;mouse model;Mucins;new therapeutic target;Optics;Organism;pathogen;pathogenic bacteria;Pattern;Play;Polysaccharides;predictive tools;preservation;Production;Proteins;Proteome;Public Health;Regulation;Research;Role;Route;Seasons;Small Intestines;Spatial Distribution;Structure;Surface;Testing;therapy development;Tissues;tool;transmission process;Vesicle;Vibrio;Vibrio cholerae;Vibrio cholerae infection

PROJECT_TITLE: Vibrio cholerae biofilms: structure, function, regulation and role in infection

STUDY_SECTION: BACP

STUDY_SECTION_NAME: Bacterial Pathogenesis Study Section[BACP]


NIH_SPENDING_CATS: Behavioral and Social Science;Chronic Liver Disease and Cirrhosis;Clinical Research;Data Science;Digestive Diseases;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Liver Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Organ Transplantation;Racial and Ethnic Minority Health Research;Social Determinants of Health;Transplantation

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Project Narrative Liver transplantation (LT) is the only curative treatment for patients with cirrhosis, and racial/ethnic disparities exist regarding whom is placed on the waitlist for this lifesaving organ. Dr. Strauss will develop a data-driven and equity-focused intervention that will improve objectivity in team decision-making for LT listing. By focusing on this critical point of the LT process, more patients from vulnerable populations will have access to the waitlist and transplantation.

PI_NAMEs: STRAUSS, ALEXANDRA TERESA (contact)

PROGRAM_OFFICER_NAME: LOH, KATRINA SHUEH WEN

PROJECT_TERMS: access disparities;Address;Adherence;Adult;Affect;Award;Awareness;Bioethics;Bioethics Consultants;black patient;Cessation of life;Characteristics;Charge;Cirrhosis;Clinical;clinical decision support;cohort;comorbidity;Complex;curative treatments;Data;Data Display;Data Science;Data Scientist;Decision Making;Decision Support Systems;Delphi Technique;demographics;design;Disparity;Documentation;Dropout;Engineering;Epidemiologist;Equity;ethnic disparity;Ethnic Origin;Evaluation;Evidence based intervention;experience;Feedback;Focus Groups;Funding;Future;Goals;Health Disparities Research;health disparity;health equity;Health equity research;Healthcare;Hepatology;Hispanic;implementation science;implementation trial;improved;Informatics;insight;Institutional Racism;interdisciplinary approach;Intervention;Learning;Life;Liver;Liver diseases;liver transplantation;Machine Learning;machine learning method;machine learning model;mathematical model;Measures;Medical;Medical center;Mentors;Methods;Modeling;Molds;mortality;multilevel analysis;Organ;Outcome;Pathway interactions;patient-level barriers;Patients;Physicians;Predictive Analytics;predictive modeling;primary outcome;Process;Process Measure;Promoting Action on Research Implementation in Health Services framework;Protocols documentation;Provider;psychosocial;Psychosocial Assessment and Care;Public Health Schools;Qualitative Methods;Qualitative Research;Race;racial disparity;racism;Research;research clinical testing;satisfaction;Scientist;secondary outcome;Severity of illness;skills;social;social health determinants;Socioeconomic Status;supervised learning;Supervision;support tools;System;Techniques;Testing;Time;tool development;Training;transplant centers;Transplant Recipients;Transplant Surgeon;Transplantation;Vulnerable Populations;Waiting Lists;Work

PROJECT_TITLE: Addressing racial and ethnic disparities in access to the liver transplant waiting list: a data science-focused and team-based approach

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK(M1)-1-C]


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Gene Therapy;Genetics;Immunotherapy;Lung;Orphan Drug;Pulmonary Fibrosis;Rare Diseases;Scleroderma

ORG_CITY: HANOVER

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: PROJECT NARRATIVE Systemic sclerosis (SSc) is a disease characterized by fibrosis and inflammation. There are no cures and very few therapeutic options for SSc patients. Prior work implicates an important role for macrophages (big eater cells) in the pathology of SSc, and the studies we propose will target macrophages using a novel cellular immunotherapeutic approach that has been used with success in the treatment of other diseases, including cancer.

PI_NAMEs: PIOLI, PATRICIA A. (contact);WHITFIELD, MICHAEL L

PROGRAM_OFFICER_NAME: RICE, JEFFREY S

PROJECT_TERMS: Affect;Autoantibodies;Autoimmune Diseases;Automobile Driving;Biological Assay;Bleomycin;Blood Vessels;Body System;CAR T cell therapy;Case Fatality Rates;Cell Therapy;cell type;Cells;Cellular immunotherapy;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;chimeric antigen receptor;chimeric antigen receptor T cells;Chronic;Clinical Pathology;cohort;Collagen;combat;Data;Death Rate;Defect;Deposition;Dermal;design;Development;Diagnosis;Disease;Disease Progression;Dose;Dropout;efficacy evaluation;Engineering;Extracellular Matrix;Fibroblasts;Fibrosis;Foundations;Gene Expression;Gene Expression Profiling;Generations;Genes;genome-wide;Genomics;Heterogeneity;Immune System Diseases;Immunotherapeutic agent;Immunotherapy;Impairment;in vivo;Inflammation;inflammatory marker;Innate Immune Response;Innate Immune System;insight;Laboratories;Lung;Macrophage;Maintenance;Malignant Neoplasms;manufacture;Measures;Methodology;Modeling;Molecular;Monitor;mortality;mouse model;Myelogenous;Nature;novel;novel therapeutic intervention;Organ;Pathogenesis;Pathology;Pathway Analysis;Patients;pre-clinical;preclinical study;Process;Production;Pulmonary Fibrosis;Qualifying;Quality of life;Receptor Gene;Research;response;Role;Skin;skin fibrosis;Standardization;success;systemic autoimmune disease;Systemic Scleroderma;T-Cell Receptor Therapy;T-Lymphocyte;targeted treatment;Technology;Testing;Therapeutic;therapeutic target;therapy development;Thick;Tissues;Treatment Efficacy;Vascular Diseases;Work

PROJECT_TITLE: Cellular Immunotherapy to Combat Fibrosis and Inflammation in Systemic Sclerosis

STUDY_SECTION: ACTS

STUDY_SECTION_NAME: Arthritis, Connective Tissue and Skin Study Section[ACTS]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Coronaviruses;Coronaviruses Vaccines;Emerging Infectious Diseases;Genetics;HIV/AIDS;Immunization;Immunotherapy;Infectious Diseases;Nanotechnology;Orthopoxviruses;Prevention;Rare Diseases;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: PHILADELPHIA

ORG_NAME: THOMAS JEFFERSON UNIVERSITY

PHR: Statement  The goal of this application is to understand the mechanisms whereby modified mRNA vaccines encapsulated in lipid nanoparticles induce memory CD8 T-cells that protect from systemic and respiratory infections. The results will have important implications for rationally designing CD8 T-cell vaccines for human use.

PI_NAMEs: SIGAL, LUIS J (contact)

PROGRAM_OFFICER_NAME: MALLIA, CONRAD M

PROJECT_TERMS: 2019-nCoV;ACE2;Affect;Antigen Presentation;Antigen-Presenting Cells;Antigens;B-Lymphocytes;Binding;Bone Marrow;CD8-Positive T-Lymphocytes;Cell surface;Cells;combat;Complement;Cross Presentation;cytokine;Cytokine Signaling;Cytoprotection;Data;Dendritic Cells;Development;Disease Outbreaks;draining lymph node;Encapsulated;experimental study;Family;Feedback;Generations;Goals;Hematopoietic;Histocompatibility;Human;IFNAR1 gene;Immune response;Immunity;Immunize;immunogenic;immunoregulation;improved;In Vitro;in vivo;Infection;Infectious Ectromelia;Inflammatory;interest;Interferon Type I;Interferon Type II;Interferon-beta;Interferons;Interleukin-6;Langerhans cell;lipid nanoparticle;Lung;Macrophage;Malignant Neoplasms;Mediating;Memory;Messenger RNA;Modeling;Monkeypox virus;monocyte;mouse model;Mouse Pox Virus;Mus;Orthopoxvirus;Peptides;Play;Population;Process;Production;Publishing;rational design;receptor;recruit;Refractory;respiratory;Respiratory Tract Infections;RNA;RNA vaccine;Role;SARS-CoV-2 spike protein;secondary infection;Source;Systemic infection;T cell differentiation;T cell response;T-Cell Development;T-Lymphocyte;T-Lymphocyte Epitopes;Tissues;TNF gene;transcriptome;Transgenic Mice;Vaccinated;Vaccination;vaccine platform;Vaccines;Variola major virus;Viral;Virus;Virus Diseases;Wild Type Mouse;Work

PROJECT_TITLE: Mechanisms of protective memory CD8 T-cell induction by mRNA-LNP vaccines

STUDY_SECTION: VID

STUDY_SECTION_NAME: Vaccines Against Infectious Diseases Study Section[VID]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Epilepsy;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences

ORG_DEPT: NEUROSURGERY

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: Project Narrative There is an urgent need to develop a deeper understanding of the neural basis of depression, given its tremendous societal impact. Previous work has been hampered by imprecise neurophysiological recordings and analysis methods that are difficult to generalize. Here, we leverage access to intracranial recording and stimulation studies in participants across a range of depression severity, along with novel explainable AI (XAI) tools, to shed light on this complex brain-behavior relationship, with the hope that a deeper understanding of the neural basis of depression will produce opportunities for improved therapies for this debilitating disorder.

PI_NAMEs: BIJANKI, KELLY ROWE;PITKOW, ZACHARY SAMUEL;SHETH, SAMEER ANIL (contact)

PROGRAM_OFFICER_NAME: TILGHMAN, JESSICA IRENE

PROJECT_TERMS: Address;Affect;Affective;Area;artificial intelligence model;Attention;Behavior;behavior influence;Behavioral;behavioral response;Belief;Black Box;Brain;brain behavior;Brain region;Cognition;Cognitive;cognitive control;cognitive task;cohort;comorbid depression;Complex;computational neuroscience;control theory;Data;Data Set;Deep Brain Stimulation;Diagnostic;disability;Disease;Economic Burden;Electric Stimulation;Electrodes;Emotional;emotional stimulus;Entropy;Epilepsy;experience;explainable artificial intelligence;Functional disorder;Funding;Goals;Heterogeneity;Human;human subject;improved;in silico;indexing;Individual;innovation;Inpatients;insight;interest;Intractable Epilepsy;Investigation;Link;Machine Learning;machine learning model;Measurable;Measures;Mental Depression;Mental disorders;Methods;model building;Modeling;Monitor;mood regulation;Moods;multidisciplinary;Negative Valence;Nervous System Disorder;neural;neural correlate;neural model;Neurobiology;neurophysiology;neuroregulation;Neurosciences;Non-linear Models;novel;novel strategies;Participant;Patient Self-Report;Patients;Pattern;Performance;Population;Positive Valence;Psyche structure;recurrent neural network;Reporting;Research;Research Domain Criteria;response;Rewards;Sampling;Seizures;Severities;Site;Societies;spatiotemporal;Structure;Symptoms;System;Task Performances;Testing;Therapeutic;Therapeutic Intervention;therapy development;tool;Training;treatment optimization;treatment strategy;treatment-resistant depression;United States National Institutes of Health;Variant;Work

PROJECT_TITLE: Intracranial Investigation of Neural Circuity Underlying Human Mood

STUDY_SECTION: HCMF

STUDY_SECTION_NAME: Human Complex Mental Function Study Section[HCMF]


NIH_SPENDING_CATS: Kidney Disease;Neurosciences

ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Project Narrative It remains unknown how cells in the body detect water content, a key step for maintaining water balance critical for all terrestrial life. The project will reveal a novel mechanism by which cells detect changes in water content and will bring fresh insights into our understanding of normal physiology and diseases of water balance disorders.

PI_NAMEs: HUANG, CHOU-LONG  (contact)

PROGRAM_OFFICER_NAME: KETCHUM, CHRISTIAN J

PROJECT_TERMS: absorption;Action Potentials;Acute;Affect;Alanine;Animals;Axon;Blinded;Blood Circulation;blood-brain barrier function;Body Water;Brain;Cell Volumes;Cells;Central Diabetes Insipidus;conditional knockout;Cultured Cells;Diabetes Insipidus;Disease;drinking;drinking water;Electrolytes;Electrophysiology (science);Environment;equilibration disorder;Equilibrium;Exhibits;experimental study;Experimental Water Deprivation;extracellular;Family;Feedback;Frequencies;gain of function mutation;Genotype;Goals;Health;Homeostasis;Human;hyperkalemia;hypertensive;In Situ;Individual;inhibitor;insight;Ion Channel;Kidney;knock-down;Knockout Mice;Life;Liquid substance;Lysine;magnocellular;Measures;Mediating;Metabolic;metabolic abnormality assessment;Molecular;Molecular Target;Mus;Mutation;Neurons;novel;Organ;organum vasculosum of the lamina terminalis;Osmolalities;Osmoregulation;Osmosis;Oxidative Stress;paraventricular nucleus;Pathway interactions;Phenotype;Phosphorylation;Phosphotransferases;Physiology;Play;Polyuria;Posterior Pituitary Gland;Process;Proline;protein function;Protein Kinase;Recombinants;Recovery;Refractory;Regulation;response;Role;sensor;Serum;Signal Transduction;Single-Blind Study;Slice;small hairpin RNA;Subfornical Organ;supraoptic nucleus;Testing;Thirst;Travel;Type II Pseudohypoaldosteronism;Urine;Vasopressins;Virus;Voltage-Gated Potassium Channel;Water

PROJECT_TITLE: WNK kinase cascade in health and disease

STUDY_SECTION: KUFD

STUDY_SECTION_NAME: Kidney and Urological Systems Function and Dysfunction Study Section[KUFD]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Mental Health;Prevention;Social Determinants of Health

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative In many global settings, key populations are more likely to be infected with HIV, but less likely to be virally suppressed than members of the general population living with HIV and research shows that this is at least partly due to the multiple stigmas that act as barriers to care-seeking, prescription refills and consistent consumption of their medications. The proposed study seeks to address this problem by adapting and pilot testing a culturally appropriate, comprehensive wellness program that incorporates peer navigation and is based on our previous work in India and South Africa, to improve engagement in HIV care among men who have sex with men and transgender women in India. If successful, the proposed low-cost strategies, tailored to the needs of sexual minorities, can improve both the health of the participants, decrease the likelihood of HIV transmission to their uninfected sex partners and be adapted for use in other global settings including the US.

PI_NAMEs: EKSTRAND, MARIA L. (contact);STEWARD, WAYNE T

PROGRAM_OFFICER_NAME: GREENWOOD, GREGORY LOUIS

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;Adoption;Affect;antiretroviral therapy;Appointment;arm;attentional control;Awareness;barrier to care;Behavior;care seeking;Caring;Clinic Visits;Collaborations;Communities;community engagement;Consumption;Continuity of Patient Care;cost;Counseling;Data;Disclosure;Disparity;Drops;Educational workshop;effective intervention;Eligibility Determination;Ensure;Environment;experience;feasibility trial;Feedback;flexibility;Fright;Future;General Population;Government;Health;High Prevalence;HIV;improved;India;Intervention;intervention participants;Interview;Interviewer;Lead;Learning;Legal;Link;Mainstreaming;Manuals;Medical;Medical center;medication compliance;member;men who have sex with men;Mental Depression;minority stress;Modeling;Modification;navigator intervention;Newly Diagnosed;operation;Outcome;Pamphlets;Participant;patient engagement;peer;perceived discrimination;Persons;Pharmaceutical Preparations;pilot test;pilot trial;Policies;Population;Positioning Attribute;preference;Prevalence;Preventive;Procedures;Process;Professional counselor;programs;Quality of life;Questionnaires;Randomized;Randomized, Controlled Trials;Recommendation;Recording of previous events;Regimen;Reporting;Research;Resources;Schedule;Services;sexual minority;Sexual Partners;social stigma;South Africa;Stress;Testing;theories;therapy adherence;Time;transgender women;transmission process;trial design;Trust;Viral;Viral Load result;viral transmission;virtual;Virus Replication;Wellness Program;Work

PROJECT_TITLE: Adapting an effective intervention for enhancing engagement in HIV care to meet the needs of key populations in India

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Networking and Information Technology R&D (NITRD);Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: Project Narrative Peripheral artery disease (PAD) is a common and highly morbid condition that is a major cause of disability and associated with a high risk of heart attack, stroke and death. We propose to develop a large cohort of PAD patients identified using a novel method and follow them over time to better understand the trajectory of survival and clinical outcomes in these patients, assess the impact of existing treatments on patient outcomes and uncover racial disparities in care and outcomes. Our work will advance PAD research and provide important insights regarding how best to improve PAD care.

PI_NAMEs: GIROTRA, SAKET  (contact)

PROJECT_TERMS: Algorithms;American;American Heart Association;Amputation;Ankle;Arteries;Attenuated;Big Data;Big Data Methods;black patient;Black race;Blood flow;Blood Pressure;blood pressure control;Cardiovascular Diseases;Cardiovascular system;care delivery;Caring;Cessation of life;Characteristics;Chronic Care;Chronic Disease;Clinical;Clinical Practice Guideline;Clinical Trials;Code;cohort;comorbidity;Coronary Arteriosclerosis;cost;critical limb Ischemia;Data;Data Element;Decision Making;Diabetes Mellitus;Diagnosis;Disabilities experience;disability;discrete data;disease diagnosis;Disease Management;Disease Outcome;Disparity;disparity reduction;effective therapy;Electronic Health Record;ethnic disparity;Ethnic Origin;Evaluation;Event;Face;Funding;Future;glycemic control;Glycosylated hemoglobin A;health care disparity;Health Services Research;high risk;high risk population;Hispanic;hospital care;Hospitals;improved;Incidence;indexing;Informatics;innovation;insight;Integrated Health Care Systems;International Classification of Disease Codes;Knowledge;Laboratories;Leg;Life Style;Limb structure;Longitudinal cohort;Medical;Methodology;Methods;mortality;multilevel analysis;Myocardial Infarction;Natural Language Processing;Newly Diagnosed;novel;novel strategies;Outcome;Outcome Study;Pain in lower limb;Patient Selection;Patient-Focused Outcomes;Patients;Pattern;Peripheral arterial disease;Pharmaceutical Preparations;Prediction of Response to Therapy;Predictive Value;Probability;programs;Quality of Care;Race;racial disparity;racial diversity;Recommendation;Reporting;Research;research and development;revascularization;Risk;Risk Factors;Science;Scientific Advances and Accomplishments;Selection Bias;Sensitivity and Specificity;Severity of illness;Site;Socioeconomic Factors;Specificity;Stroke;Structural Models;Symptoms;System;Testing;Time;time use;Toes;tool;Treatment Factor;treatment pattern;United States Department of Veterans Affairs;Variant;Veterans;Veterans Health Administration;Work

PROJECT_TITLE: Peripheral Artery Disease: Long-term Survival & Outcomes Study (PEARLS)

STUDY_SECTION: HSQE

STUDY_SECTION_NAME: Health Services: Quality and Effectiveness Study Section[HSQE]


NIH_SPENDING_CATS: Biotechnology;Gene Therapy;Genetics;Hematology;Orphan Drug;Rare Diseases

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: Project Narrative The overall goal of this proposal is to use AAV liver gene therapy for the treatment of hemophilia A (FVIII deficiency) complicated inhibitory antibodies to FVIII; to this end, we will use novel canine models of severe hemophilia A that develop robust high-responding immune responses to canine FVIII. Unique to this approach is that after eradication of inhibitors and induction of immune tolerance, AAV-mediated continuous expression of FVIII will also improve the disease bleeding phenotype. The success of this approach will support this strategy for applications in hemophilia with inhibitors, the most challenging clinical scenario, and other diseases complicated by the development of neutralizing antibodies to the therapeutic protein.

PI_NAMEs: SAMELSON-JONES, BEN J (contact)

PROGRAM_OFFICER_NAME: WARREN, RONALD Q

PROJECT_TERMS: adeno-associated viral vector;Affect;Antibodies;B-Lymphocytes;Biology;Blood;Blood Coagulation Disorders;Breeding;canine model;Canis familiaris;Catheters;Cell Line;Cells;Clinical;Clinical Trials;cost;Data;Development;Disease;Dose;efficacy evaluation;enzyme replacement therapy;F8 gene;Factor VIII;Gene Mutation;gene therapy;gene therapy clinical trial;Gene Transfer;Genetic Diseases;Goals;Hemophilia A;Hemorrhage;Hepatotoxicity;Human;Immune;Immune response;Immune Tolerance;improved;ineffective therapies;Infusion procedures;inhibitor;Injections;Isoantibodies;Kinetics;Link;Liver;Maintenance;male;manufacture;manufacturing process;Measures;Mediating;Modeling;Morbidity - disease rate;mortality;Mutation;neutralizing antibody;novel;novel strategies;Other Genetics;Outcome;Patients;Pharmaceutical Preparations;Phenotype;prevent;Prophylactic treatment;Proteins;Protocols documentation;Publishing;Recombinant adeno-associated virus (rAAV);Regimen;Regulatory T-Lymphocyte;Replacement Therapy;Reporting;Residual state;restoration;Role;Safety;Serotyping;Sf9 cell line;Study models;success;System;Testing;Therapeutic;therapeutic protein;Time;Transgenes;vector;Venous

PROJECT_TITLE: Immune tolerance induction by AAV-FVIII gene therapy for canine hemophilia A with inhibitors

STUDY_SECTION: TAG

STUDY_SECTION_NAME: Therapeutic Approaches to Genetic Diseases Study Section[TAG]


NIH_SPENDING_CATS: Biotechnology;Cancer;Immunotherapy;Prostate Cancer;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human;Urologic Diseases

ORG_CITY: WORCESTER

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: Project Narrative This proposal seeks to understand mechanisms that contribute to the aggressive behavior of advanced prostate cancers and to use the information obtained to improve therapy. The specific focus is neuropilin-2, a receptor for vascular endothelial growth factor (VEGF) on tumors that promotes chemoresistance and immune evasion. Therapeutic targeting of NRP2 has the potential to reduce the morbidity and mortality associated with advanced prostate cancers by increasing chemosensitivity and immune cell killing.

PI_NAMEs: MERCURIO, ARTHUR M (contact)

PROGRAM_OFFICER_NAME: GREENBERG, WILLIAM A

PROJECT_TERMS: Address;Adenocarcinoma;advanced prostate cancer;Aggressive behavior;autocrine;Binding;cell killing;Cells;checkpoint inhibition;Chemoresistance;chemotherapy;Clinic;Clinical Trials;Coupled;Data;effective therapy;exosome;Goals;humanized antibody;Immune;Immune checkpoint inhibitor;Immune Evasion;Immune response;Immunocompetent;Immunosuppression;improved;inhibitor;Invaded;Malignant neoplasm of prostate;Malignant Neoplasms;manufacture;Mediating;Metastatic Prostate Cancer;Modeling;Monoclonal Antibodies;Morbidity - disease rate;mortality;Mus;Neoplasm Metastasis;neoplastic cell;Neuroendocrine Prostate Cancer;Neuroendocrine Therapy;Neuropilin-2;nonhuman primate;novel;novel therapeutic intervention;NPR2 gene;Outcome;Phenotype;Predisposition;pressure;programmed cell death ligand 1;programmed cell death protein 1;Property;prostate cancer model;receptor;Reporting;Resistance;response;Role;Signal Transduction;stem cells;stemness;Therapeutic;therapeutic target;Toxic effect;translational potential;treatment strategy;tumor;Tumor Burden;Tumor Immunity;tumor progression;Tumor Promotion;Up-Regulation;Vascular Endothelial Growth Factors;Work

PROJECT_TITLE: Novel Therapeutic Approaches for Aggressive Prostate Cancer

STUDY_SECTION: ATA

STUDY_SECTION_NAME:
Advancing Therapeutics A Study Section
[ATA]


NIH_SPENDING_CATS: Antimicrobial Resistance;Genetics;Infectious Diseases;Malaria;Rare Diseases;Vector-Borne Diseases

ORG_NAME: DUKE UNIVERSITY

PHR: Project Narrative Malaria is a life-threatening disease that is caused by infection from Plasmodium parasites. Resolving pathways critical to both the liver and blood stages of Plasmodium infection, such as ones that involve heat shock proteins, is critical to aid in malaria control. This project will investigate the role of heat shock proteins 90 and 70 in Plasmodium infection to advance knowledge of essential parasite processes and aid in the pursuit of novel therapeutic strategies.

PI_NAMEs: DERBYSHIRE, EMILY R (contact)

PROGRAM_OFFICER_NAME: MCGUGAN, GLEN C

PROJECT_TERMS: Address;Affinity;Amino Acids;analog;Anti-malarials;Binding;Binding Proteins;Binding Sites;Biochemical;Biological;biological adaptation to stress;Biological Assay;Biological Process;Biology;Blood;C-terminal;Calorimetry;Cells;Chemicals;chemoproteomics;Client;Competitive Binding;Critical Pathways;dimer;Disease;Drug Combinations;Drug resistance;Drug Targeting;Foundations;Gene Expression;Genes;Genetic;Genetic Transcription;global health;Goals;Heat shock proteins;Heat Stress;Heat-Shock Proteins 90;Hepatocyte;Homeostasis;Human;Individual;inhibitor;insight;Knowledge;Label;Life;Life Cycle Stages;Ligand Binding;Ligands;Link;Lipids;live cell microscopy;Liver;Malaria;Mass Spectrum Analysis;Measures;Methods;Modernization;Molecular;Molecular Chaperones;N-terminal;new therapeutic target;novel;novel therapeutic intervention;Nucleotides;Ontology;Organelles;oxidation;Parasite resistance;Parasites;pathogen;Pathway interactions;Permeability;Plasmodium;Plasmodium falciparum;Population;Process;Property;protein function;Proteins;Proteolysis;Proteome;proteostasis;Regulation;Resistance;resistant strain;Role;Route;scaffold;screening;Signal Transduction;Site;small molecule;System;Tertiary Protein Structure;Therapeutic;Titrations;tool;transcriptome;transcriptome sequencing;Vacuole;validation studies;Work

PROJECT_TITLE: Chemical Biology Strategies to Resolve Plasmodium Heat Shock Protein Function

STUDY_SECTION: CBP

STUDY_SECTION_NAME: Chemical Biology and Probes Study Section[CBP]


NIH_SPENDING_CATS: Biotechnology;Infectious Diseases;Machine Learning and Artificial Intelligence

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: PROJECT NARRATIVE There are few active antibiotics against Gram-negative bacteria due to the presence of the outer membrane surrounding these pathogens, which creates a major barrier for the penetration of small molecules. We propose to develop an innovative framework to understand antibiotic penetration and establish a metabolic labeling assay to measure outer membrane penetration that is uncoupled from inhibitory activity. Ultimately, our tools can be applied to various pathogens and to design better antibiotics for the treatment of human diseases.

PI_NAMEs: PIRES, MARCOS M. (contact)

PROGRAM_OFFICER_NAME: ERNST, NANCY L

PROJECT_TERMS: 3-Dimensional;Academia;Agreement;Alkynes;Antibiotic Therapy;Antibiotics;Azides;Bacteria;Binding Sites;Biochemical;Biological Assay;Biology;cell envelope;Cells;Chemicals;cheminformatics;Collection;Communities;cycloaddition;Cytoplasm;Data;Data Set;design;drug discovery;Drug Targeting;efflux pump;Epitopes;Escherichia coli;Fluorescence;fluorophore;Foundations;Genomics;Gram-Negative Bacteria;Healthcare;high throughput analysis;human disease;Industry;infection risk;innovation;instrumentation;Knock-in;Knock-out;Label;Laboratories;Libraries;machine learning algorithm;Measurable;Measures;Medical;Membrane;Metabolic;metabolomics;Methodology;Methods;minimal risk;Modernization;Molecular;novel;Operative Surgical Procedures;Organelles;Organic Synthesis;pathogen;Penetration;periplasm;Permeability;Pharmaceutical Chemistry;Pharmaceutical Preparations;Phase;Physical condensation;Predisposition;Proteomics;Reaction;Reagent;Research;Resolution;Science;screening;small molecule;small molecule libraries;Specificity;structural determinants;subcellular targeting;Testing;Three-Dimensional Imaging;tool;ultra high resolution;VDAC1 gene;Work

PROJECT_TITLE: Structural Determinants of Permeation Barriers in Escherichia coli