ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Biomedical Imaging;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Heart Disease;Kidney Disease;Neurosciences;Prevention

PHR: PROJECT NARRATIVE Our studies over the past several years have characterized the cholinergic anti-inflammatory reflex pathway (CAP), the neuroimmune axis that contributes to an anti-inflammatory response and prevention of acute kidney injury (AKI). We have found that either electrical vagus nerve stimulation or pulsed ultrasound (US) targeted to the spleen equally protects kidneys from AKI by activating the cholinergic anti-inflammatory reflex pathway (CAP), a neuroimmune circuit that controls systemic inflammation. Based upon these preclinical studies, we propose a pilot and feasibility study to demonstrate that pulsed US stimulation using a clinical ultrasound machine approved for its use in humans can be used effectively and safely in human subjects to attenuate the inflammatory function of immune cells collected from healthy subjects and patients undergoing cardiac surgery post US-stimulation.

PI_NAMEs: OKUSA, MARK DOUGLAS (contact);ROSNER, MITCHELL H.

PROGRAM_OFFICER_NAME: SCHULMAN, IVONNE HERNANDEZ

PROJECT_TERMS: Acute Renal Failure with Renal Papillary Necrosis;Address;Adult;alpha-bungarotoxin receptor;Animal Model;Anti-Inflammatory Agents;Attenuated;Blood;Bone Marrow;Cardiac Surgery procedures;Cardiopulmonary Bypass;CD4 Positive T Lymphocytes;Cells;cholinergic;Clinical;Clinical Research;Clinical Trials;Collecting Cell;cytokine;Data;Denervation;design;Development;Diagnostic;Disease;early detection biomarkers;efficacy evaluation;Elements;Enrollment;Event;FDA approved;Feasibility Studies;Feedback;Functional disorder;Future;Goals;Health;Homeostasis;Human;human disease;human subject;Human Volunteers;Immune;immune function;Immune response;Immune system;Immunologics;immunopathology;Incidence;Inflammation;Inflammatory;Inflammatory Response;Injury;innovation;Kidney;kidney dysfunction;kidney fibrosis;LCN2 gene;Maps;Mission;Modeling;mortality;Multicenter Trials;Mus;National Institute of Diabetes and Digestive and Kidney Diseases;Natural Immunity;Nature;Nerve;nerve supply;Nervous System;Neuroimmune;Neuroimmunomodulation;novel strategies;Operative Surgical Procedures;Participant;Pathogenicity;Pathway interactions;Patients;Perioperative;Peripheral;Pharmaceutical Preparations;pharmacologic;Physiologic pulse;Pilot Projects;Placebos;Populations at Risk;pre-clinical;preclinical study;prevent;Prevention;Production;protective effect;Protocols documentation;Randomized;Randomized, Controlled Trials;Reflex action;Regulatory T-Lymphocyte;renal ischemia;Renal Replacement Therapy;Reperfusion Injury;Reporting;response;Risk;Risk Reduction;Role;Safety;safety outcomes;secondary endpoint;Secondary to;Sepsis;Severities;side effect;Spleen;Splenectomy;Stimulus;systemic inflammatory response;T-Lymphocyte;Testing;TIMP2 gene;Tissues;Translating;Ultrasonography;ultrasound;vagus nerve stimulation

PROJECT_TITLE: Proof of concept and feasibility in humans for pulsed ultrasound treatment to reduce inflammation and risk of AKI

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


ADMINISTERING_IC: MH

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Mental Health;Mental Illness;Pediatric

ORG_CITY: BINGHAMTON

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PSYCHOLOGY

ORG_FIPS: US

ORG_NAME: STATE UNIVERSITY OF NY,BINGHAMTON

ORG_STATE: NY

PHR: PROJECT NARRATIVE The proposed study represents an important step in understanding why offspring of mothers with depression are at increased risk for depression themselves and may help to highlight the mechanisms underlying the development of an early-emerging risk factor – attentional avoidance of facial displays of sadness. These results could help provide important information not only about where to intervene but when to intervene with offspring of depressed mothers. As such, the results could pave the way for more focused interventions for at-risk children.

PI_NAMEs: GIBB, BRANDON E (contact)

PROGRAM_OFFICER_NAME: KING, ERIN MICHELE

PROJECT_TERMS: Address;Affect;Affective;Anxiety;Area;Arousal;Attention;attentional bias;Behavior;Birth;boys;Child;child depression;Child Rearing;Code;comorbidity;Computers;Cross-Sectional Studies;Cues;Depressed mood;depressive symptoms;design;Development;Disease;emotion regulation;Emotional;Emotions;Exposure to;Face;Facial Expression;Family;Future;Galvanic Skin Response;girls;Grain;Heart Rate;Income;indexing;infancy;Infant;Infant Development;infant outcome;Intervention;Laboratories;Life;Link;Literature;maternal depression;Measures;Mediating;Mental Depression;Methods;mood regulation;Mothers;offspring;Physiological;Process;prospective;Publishing;Recording of previous events;recruit;Research;Research Personnel;respiratory;Risk;Risk Factors;Sampling;showing emotion;Sinus Arrhythmia;social;social emotional learning;Specificity;Standardization;Stress;Symptoms;Testing;theories;Time;Transact;visual tracking;Withdrawal;Work

PROJECT_TITLE: Development of Attentional Biases for Affective Cues in Infants of Mothers with Depression

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Gene Therapy;Genetic Testing;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Maternal Health;Orphan Drug;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Rare Diseases;Women's Health Research

ORG_CITY: DURHAM

ORG_DEPT: PEDIATRICS

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE The proposed work seeks to improve human health by developing strategies to risk stratify and identify candidate individuals for genetic testing and treatment in early life. With therapeutic intervention becoming available at earlier time points in life for treatable inherited genetic diseases, I aim to accelerate the time to diagnosis for these conditions. Access to genomic diagnostics and therapeutics in early life is often limited; my work aims to develop strategies to equitably deliver genomic medicine and offer earlier opportunities for diagnosis and treatment.

PI_NAMEs: COHEN, JENNIFER L (contact)

PROGRAM_OFFICER_NAME: KAU, ALICE S

PROJECT_TERMS: Acceleration;Address;Adult;Affect;Algorithms;American;American College of Obstetricians and Gynecologists;biobank;Biological Markers;candidate identification;carrier status;carrier testing;Child;Childhood;Classification;Clinical;clinical practice;cohort;Cohort Studies;Conceptions;conflict resolution;Consent;Coupled;Cystic Fibrosis;Data;Data Set;Databases;Development;Diagnosis;Diagnostic;Disease;Early Diagnosis;Early treatment;efficacy evaluation;Enrollment;enzyme replacement therapy;Equity;exome sequencing;experience;Family;Family history of;fetal;Fetal Development;Fetal health;Fetus;fetus at risk;Frequencies;Future;Gene Frequency;gene therapy;gene-targeted therapy;Genes;Genetic;Genetic Diseases;genetic disorder diagnosis;Genetic Screening;genetic testing;genetic variant;genome sequencing;genomic epidemiology;Genomic medicine;Genomics;Gestational Diabetes;Glycogen storage disease type II;Goals;Grant;Guidelines;Health;health data;Hereditary Disease;high risk;Human;hypohidrotic ectodermal dysplasia;improved;in utero;Individual;Infant;Inherited;innovation;insight;Intervention;Life;Link;Lysosomal Storage Diseases;Machine Learning;machine learning model;Maternal Health;Measures;Medical Ethics;Medical Genetics;medical schools;Medical Societies;Mentored Patient-Oriented Research Career Development Award;Mentorship;Methods;Modeling;Mothers;Motion;Multi-Institutional Clinical Trial;Neonatal Intensive Care Units;Neonatal Screening;neonate;Newborn Infant;North Carolina;novel;novel strategies;offspring;Pathologic Processes;Patients;phase I trial;Phenotype;Pilot Projects;Placenta;Placental Infarction;Population;population based;postnatal;Pre-Eclampsia;predictive marker;predictive modeling;Pregnancy;pregnancy health;pregnant;Pregnant Women;prenatal;Prenatal Diagnosis;prenatal therapy;Prevalence;programs;prospective;Public Health;public health research;Rare Diseases;Recommendation;Recontacts;Records;Research;Retrospective cohort;Risk;risk stratification;Role;Sample Size;screening;screening guidelines;skills;Statistical Models;Symptoms;Testing;Therapeutic;Therapeutic Intervention;Time;Training;Update;uptake;Validation;Work

PROJECT_TITLE: Developing strategies to identify candidate individuals for early genetic therapies

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Obstetrics and Maternal-Fetal Biology Study Section[CHHD-B]


ADMINISTERING_IC: AI

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Natural Products;Orphan Drug;Rare Diseases

ORG_CITY: MADISON

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Botulism is a severe and potentially lethal neuro-paralytic disease of long duration, lasting up to several months and requiring extensive medical care, which would create a devastating scenario in an unintentional or intentional large outbreak, yet, BoNTs are also widely used as valuable human biotherapies to treat more than 200 neuromuscular disorders. Besides an equine antiserum known as BAT, which can be improve and shorten disease outcome if given within the first 2-3 days intoxication when diagnosis often is still uncertain, there is no cure for botulism. Completion of the studies in this proposal will provide a detailed understanding of the mechanism responsible for BoNT duration and potency, which is essential for developments of novel countermeasures that are effective at later stages of the disease, and for development of new classes of BoNT therapeutic agents.

PI_NAMEs: BARBIERI, JOSEPH T;PELLETT, SABINE  (contact)

PROGRAM_OFFICER_NAME: ZEITUNI, AMIR E

PROJECT_TERMS: Address;Affect;AGFG1 gene;Amino Acids;Animals;anti-toxin;Autophagocytosis;Binding;Biological Assay;Biological Response Modifier Therapy;bioweapon;Botox;Botulinum Toxin Type A;Botulinum Toxins;Botulism;Caring;Catalysis;Categories;cell fixing;Cell membrane;Cells;cellular imaging;Characteristics;Chimera organism;Classification;Clostridium tetani;cost;Cytosol;Data;Development;Diagnosis;Disease;Disease Outbreaks;Disease Outcome;disulfide bond;Dominant-Negative Mutation;Equus caballus;experimental study;Family;Funding;Grant;holotoxins;Human;illness length;Image;Immunologics;improved;Individual;individualized medicine;Intoxication;Laboratories;Light;Link;Measures;Mediating;Medical;Membrane;Messenger RNA;Metalloproteases;Molecular;Motor Neurons;mouse model;mRNA Expression;multicatalytic endopeptidase complex;Mus;N-terminal;Neuromuscular Diseases;Neurons;novel;Paralysed;Pathway interactions;Pharmacologic Substance;Property;Protein Family;Proteins;public health emergency;Receptor Cell;Recombinants;Rodent;Role;Serotyping;Serum;Severities;Side;Standardization;Supportive care;Synaptic Vesicles;System;Technology;Testing;Therapeutic;Therapeutic Agents;therapy resistant;Time;Toxin;trafficking;translational study;Ubiquitin;Variant;Vertebrates;Vesicle;weapons;Zinc

PROJECT_TITLE: Characteristics of Botulinum Neurotoxins the Determine Potency

STUDY_SECTION: BV

STUDY_SECTION_NAME: Bacterial Virulence Study Section [BV]


ADMINISTERING_IC: OH

IC_NAME: NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH

ORG_CITY: KENT

ORG_NAME: KENT STATE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative The field of veterinary medicine is experiencing a crisis in mental health and well-being; evidence-based approaches to reduce this burden are critically needed. Recent research suggests that burden transfer to veterinary healthcare workers, occurring in the context of difficult client interactions, can be reduced using a tailored Acceptance and Commitment Training (ACT) intervention, which in turn improves psychosocial functioning. The proposed study will embed an asynchronous version of this intervention, adapted for students, into veterinary technician and medicine training programs, comparing an intervention group to controls, evaluating student reaction (i.e., engagement, perception of intervention), learning (i.e., demonstration of intervention knowledge), behavior (i.e., frequency of use of skills taught in the intervention), and results (i.e., burden transfer, stress, burnout, and symptoms of depression and anxiety) over one year as trainees transition into the workforce.

PI_NAMEs: SPITZNAGEL, MARY BETH (contact)

PROGRAM_OFFICER_NAME: LIOCE, MARIA

PROJECT_TITLE: Effects of embedded Acceptance and Commitment Training in DVM and RVT programs as students transition into the workforce

STUDY_SECTION: SOH

STUDY_SECTION_NAME: Safety and Occupational Health Study Section[SOH]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: BALTIMORE

ORG_DEPT: PHYSIOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARATIVE This project will generate new information about copper entry into the developing and adult mammalian brain and determine the role that the blood-cerebrospinal barrier plays in Wilson disease neuropathology. This information will facilitate understanding of Wilson disease and other disorders associated with copper misbalance, including Menkes disease, Alzheimer’s disease and Parkinson’s disease.

PI_NAMEs: LUTSENKO, SVETLANA  (contact)

PROGRAM_OFFICER_NAME: MORRIS, JILL A

PROJECT_TERMS: Adult;Affect;Age;Aging;Alzheimer's Disease;amidation;Animal Model;Animals;Astrocytes;Biotinylation;Blood;Blood - brain barrier anatomy;blood cerebrospinal fluid barrier;Brain;brain parenchyma;Buffers;Carrier Proteins;Cell membrane;Cells;cellular microvillus;Central Nervous System;Cerebrospinal Fluid;Characteristics;Chelating Agents;Choroid Plexus Epithelium;Cilia;Circulation;comparison control;Copper;Cysteine;Cytoskeletal Proteins;Cytoskeleton;Defect;Development;Disease;Electron Microscopy;Encephalitis;Endothelial Cells;Enterobacteria phage P1 Cre recombinase;Enzymes;Epithelial Cells;Equilibrium;experimental study;Growth Factor;Hepatolenticular Degeneration;Homeostasis;Human;immunocytochemistry;In Situ;in vivo;Individual;Injections;Iron;islet;Label;Link;Maintenance;Mass Spectrum Analysis;Measures;Menkes Kinky Hair Syndrome;Metabolic Pathway;Metallothionein;Methodology;Mixed Function Oxygenases;Molecular;Morphology;MT3 gene;Multiple Sclerosis;Mus;Mutation;myelination;Neurons;neuropathology;Neurotransmitters;Organism;Parkinson Disease;Peptide Signal Sequences;Peptides;Perinatal;perinatal brain;perinatal development;Peritoneal;Physiology;Plasma Proteins;Play;Production;programs;Protein Export Pathway;Proteins;Proteome;Proteomics;Protocols documentation;Regulation;Resolution;Role;secretory protein;Sensory;Signal Pathway;Signal Transduction;Structure of choroid plexus;Symptoms;Synaptic plasticity;Testing;Therapeutic Intervention;Time;Tissues;Transmission Electron Microscopy;Wild Type Mouse

PROJECT_TITLE: The Role of Copper in Choroid Plexus

STUDY_SECTION: NMHD

STUDY_SECTION_NAME: Nutrition and Metabolism in Health and Disease Study Section[NMHD]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Genetics;Hematology;Rare Diseases

ORG_CITY: BOSTON

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: HARVARD MEDICAL SCHOOL

ORG_STATE: MA

PHR: Narrative DNA inter-strand cross-links (ICLs) represent a dangerous type of DNA damage that human cells repair to avoid a variety of diseases including bone marrow failure and cancer. ICLs can be repaired in a variety of ways but the underlying mechanisms remain unclear. We have developed cellular extracts that recapitulate two distinct ICL repair pathways, and we will use these extracts to study the steps that lead to ICL repair, as well as the proteins that catalyze these steps.

PI_NAMEs: WALTER, JOHANNES  (contact)

PROGRAM_OFFICER_NAME: QASBA, PANKAJ

PROJECT_TERMS: Address;Aldehydes;Bone marrow failure;cancer predisposition;CDC45L gene;Cells;Cellular biology;Chemotherapy-Oncologic Procedure;Cisplatin;Complex;Coupled;crosslink;cytotoxic;Dangerousness;Dependence;Development;dimer;Disease;DNA;DNA biosynthesis;DNA glycosylase;DNA Interstrand Cross-Link Repair;DNA Interstrand Crosslinking;DNA Repair;DNA replication fork;ds-DNA;egg;Environment;Enzymes;ERCC1 gene;Event;Failure;FANCD2 protein;Fanconi Anemia pathway;Fanconi's Anemia;Foundations;Genes;Genetic Transcription;helicase;homologous recombination;Human;human disease;human DNA damage;in silico;insight;Lesion;leukemia;Link;Malignant Neoplasms;Mammalian Cell;Mechlorethamine;Molecular;Mutate;Mutation;NEIL3 gene;novel;nuclease;p97 ATPase;Pathway interactions;Patients;Pharmaceutical Preparations;Plasmids;Predisposition;premature;Process;protein crosslink;protein protein interaction;Proteins;Rana;recruit;Regulation;repair model;repaired;Resistance;Resolution;RNA Polymerase II;scaffold;screening;Site;Site-Directed Mutagenesis;Solid;Surgical incisions;Syndrome;System;Testing;Text;Therapeutic;Transcription-Coupled Repair;Travel;tumor;Ubiquitin;ubiquitin-protein ligase;Work

PROJECT_TITLE: Mechanism and regulation of DNA interstrand cross-link repair

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MGG-M (02)]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Contraception/Reproduction;Dissemination and Implementation Research;Health Services;Pediatric;Pediatric Cancer;Prevention;Rare Diseases

ORG_CITY: HARTFORD

ORG_NAME: CONNECTICUT CHILDREN'S MEDICAL CENTER

ORG_STATE: CT

PHR: PROJECT NARRATIVE Adolescent and young adults (AYAs) with cancer want to discuss relevant sexual and reproductive health (SRH) issues and concerns with their oncology clinicians during treatment and in survivorship, yet these conversations rarely take place. This inadequate communication puts AYAs at immediate risk for making uninformed decisions involving contraception, safe sex practices, and fertility preservation, while the sequelae of not addressing body image, sexuality, and sexual dysfunction can lead to profound long-term consequences for future romantic relationships, family building, and overall quality of life. In the proposed study, we will use stakeholder input to develop, refine, and assess a novel AYA-centered communication intervention to improve SRH conversations between AYAs and their oncology clinicians, with the ultimate goal of increasing AYA access to critical SRH care and education that they need across the cancer continuum.

PI_NAMEs: FREDERICK, NATASHA NICHOLE (contact)

PROGRAM_OFFICER_NAME: RADAEV, SERGEY

PROJECT_TERMS: Address;Adolescent and Young Adult;Adolescent and young adult cancer patients;adolescent health outcomes;Adult;Advisory Committees;Ambulatory Care Facilities;Anemia;Award;Behavior Therapy;Blood coagulation;Body Image;cancer care;cancer diagnosis;Cancer Survivor;Cancer Survivorship;cancer therapy;career;career development;Caring;Child;Childhood;Clinic;Clinical Trials;Cognitive;Communication;Communication Barriers;communication behavior;Communication Tools;Conduct Clinical Trials;Connecticut;Contraceptive methods;Counseling;Data;Decision Making;Dedications;design;Development;digital;digital platform;Distress;Education;education resources;Educational Materials;Educational workshop;effective intervention;efficacy evaluation;Elements;Expectancy;family building;Feedback;fertility preservation;Future;Goals;Guidelines;health communication;Health Resources;Healthcare;high risk;implementation science;improved;Intervention;Interview;Knowledge;Lesbian Gay Bisexual Transgender Queer;Los Angeles;Malignant Neoplasms;Measures;medical schools;Mental Health;Mentors;Mentorship;Methods;mHealth;Modification;multi-component intervention;multimodality;novel;oncofertility;Oncology;Online Systems;Outcome;Outpatients;Participant;Patient Education;patient oriented;Patient-Centered Care;patient-clinician communication;Patients;Pediatric Hospitals;Pediatric Oncology;post intervention;Primary Care;Procedures;Program Development;programs;prototype;Psychosexual Development;Qualitative Methods;Quality of life;Questionnaires;randomized, clinical trials;Randomized, Controlled Trials;recruit;Reporting;Reproductive Health;Research;Research Methodology;Research Personnel;Resources;Risk;Safe Sex;satisfaction;Science;Self Efficacy;Sex Functioning;sexual and reproductive health;Sexual Dysfunction;Sexual Health;sexual risk behavior;Sexuality;Signal Transduction;substance use;Surveys;Survivors;survivorship;symptom management;Technology;Testing;Therapeutic;Time;Training Activity;Treatment Efficacy;Universities;usability;Visit;web-based intervention;X Inactivation

PROJECT_TITLE: Improving Sexual and Reproductive Health Communication Between Adolescent and Young Adult Oncology Patients and Clinicians: A Patient-Centered Intervention

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Genetics;Immunotherapy;Neurosciences;Nutrition;Orphan Drug;Rare Diseases

ORG_CITY: PITTSBURGH

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE Glioblastoma ranks among the deadliest of all human cancers, with current therapies offering only palliation. In this research project, we will study how amino acid metabolism stimulates glioblastoma cells to grow and resist current therapies, empowering the design of potential new treatments for patients afflicted with glioblastoma.

PI_NAMEs: ABDULLAH, KALIL G;RICH, JEREMY N (contact)

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: Adjuvant;Affect;Age;amino acid metabolism;Amino Acids;anti-tumor immune response;Binding;Bioinformatics;Biology;Body Fluids;Brain;Brain Neoplasms;Caring;Catabolism;cell growth;Cells;Cellular biology;chemotherapy;Chemotherapy and/or radiation;Chromatin;Clinical;clinical translation;Clinical Trials;Coenzyme A;conventional therapy;Data;Dependence;derepression;design;Development;Diet;dietary;Dietary Intervention;dietary manipulation;dietary restriction;differential expression;Dimensions;Ecosystem;Elements;empowerment;Enzymes;Epigenetic Process;Epilepsy;Essential Amino Acids;Excision;fitness;Foundations;gain of function;Gene Expression;Gene Expression Regulation;Generations;Genetic;Glioblastoma;Histone H4;Histones;Human;Immune;Immune checkpoint inhibitor;Immune Evasion;Immune response;immunogenicity;Immunotherapy;improved;in vivo;Inborn Errors of Metabolism;inhibitor;Lesion;loss of function;Lysine;Lysine Degradation Pathway;Maintenance;Malignant Neoplasms;Metabolic;metabolic abnormality assessment;Metabolic Pathway;Metabolism;Modeling;Modification;Molecular;Molecular Biology;Nature;neoplastic cell;nerve stem cell;neuro-oncology;neuropathology;novel;novel therapeutics;Nuclear;Operative Surgical Procedures;Oral;Organoids;palliation;Pathogenesis;Patients;PD-1 inhibitors;Performance Status;Pharmacology Study;pre-clinical;precision medicine;programs;Protein Biosynthesis;Publishing;Radiation therapy;Regulation;Reporting;Repression;Research;Research Project Grants;response;Role;Seizures;Series;Source;Spatial Distribution;Specificity;Subgroup;Suggestion;System;T cell infiltration;targeted treatment;temozolomide;Therapeutic;therapeutic development;Translating;translational potential;Translations;Treatment Efficacy;tumor;Tumor Biology;tumor growth;tumor metabolism;Tumor Promotion;tumor-immune system interactions;uptake;Vitamin B6;Xenograft procedure

PROJECT_TITLE: Targeting Amino Acid Metabolism in Glioblastoma

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


ADMINISTERING_IC: GM

ED_INST_TYPE: HOSPITALS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics

ORG_CITY: HOUSTON

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: PROJECT NARRATIVE Our work to determine the regulatory mechanisms in linking protection of stalled replication fork integrity with innate immune response, if successful, will reveal new aspects of the replication stress response. It will also provide novel insights into establishing new possibilities for the treatment of inflammatory disorders and cancer.

PI_NAMEs: WANG, BIN  (contact)

PROGRAM_OFFICER_NAME: NELSON, SHAKIRA M

PROJECT_TERMS: Biological;biological adaptation to stress;cell motility;Cells;chemokine;cytokine;Cytoplasm;Defect;design;Disease;DNA;DNA Binding;DNA Repair;DNA replication fork;effective therapy;FANCD2 protein;Future;Genome Stability;Genomic Instability;Goals;Immune;Immune response;Immune signaling;immunodeficiency;In Vitro;in vivo;Inflammatory;Inflammatory Response;Innate Immune Response;insight;Link;Malignant Neoplasms;Mediating;mouse model;Mus;novel;Nuclear;Pathway interactions;Phenotype;Physiological;Production;replication stress;Research;response;Ribosomal DNA;Role;Single-Stranded DNA;Stimulator of Interferon Genes;Work

PROJECT_TITLE: Replication fork protection and innate immune response

STUDY_SECTION: CSRS

STUDY_SECTION_NAME: Cellular Signaling and Regulatory Systems Study Section[CSRS]


NIH_SPENDING_CATS: Bioengineering;Neurosciences

ORG_CITY: NEW YORK

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: Narrative Using high-speed atomic force microscopy (HS-AFM), we have recently discovered a hitherto unobserved pentameric state of TRPV3, which we hypothesize to be the structural correlate to the so-far elusive pore-dilation phenomenon, characterized functionally by an increase in conductance, permeability to large ions and loss of rectification. In this project we will study the pentameric state further in terms of structure and function and determine if it is indeed related to the pore-dilated state and to the different gain-of-function mutations observed in TRPV3-channel related diseases. Results from these studies are expected to provide answers to some long- standing questions in the TRP-channel research field, and to pave the way for new avenues of structural, functional, and therapeutic approaches of TRPV channels.

PI_NAMEs: SCHEURING, SIMON  (contact)

PROGRAM_OFFICER_NAME: UMANAH, GEORGE KWABENA ESSIEN

PROJECT_TERMS: Agreement;Anhydrides;Area;Atomic Force Microscopy;Capsaicin;Cryoelectron Microscopy;Diameter;Disease;disease phenotype;drug development;Drug Targeting;Electrophysiology (science);Equilibrium;gain of function;gain of function mutation;Hydrophobicity;Image;insight;Ion Channel;Ions;Knowledge;Ligand Binding;Ligands;Measurement;Membrane;Membrane Proteins;membrane reconstitution;Methods;migration;Modeling;Molecular Conformation;molecular dynamics;mutant;Mutation;Olmsted syndrome;Outcome;particle;Permeability;Phenotype;Physiological;Population;Preparation;Process;Proteins;Protomer;Rationalization;Reporting;Research;Resolution;Sampling;single molecule;Speed;Structural Models;Structure;Testing;Therapeutic;tool;TRP channel;TRPV channel;TRPV1 gene;Vanilloid;Visualization;Work

PROJECT_TITLE: Structure and Function of a Pentameric TRPV3 Channel

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MBBC-K (02)]


NIH_SPENDING_CATS: Autism;Bioengineering;Biomedical Imaging;Brain Disorders;Intellectual and Developmental Disabilities (IDD);Mental Health;Mental Illness;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn

ORG_CITY: INDIANAPOLIS

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Project Narrative Alterations in brain folding are linked to neurological and psychiatric disorders such as epilepsy, autism spectrum disorder, schizophrenia, and developmental delay. The purpose of this study is to understand the mechanical mechanisms that underlie folding, particularly the role of cortical growth gradients and white matter structure in normal and aberrant brain folding. The study will utilize computational modeling to test hypothesized mechanisms of brain folding, with validation based on high quality, longitudinal magnetic resonance imaging data previously collected from preterm infants and human fetuses.

PI_NAMEs: GARCIA, KARA E (contact)

PROGRAM_OFFICER_NAME: RIDDLE, ROBERT D

PROJECT_TERMS: 10 year old;3-Dimensional;Address;Adult;Age;Animal Model;Anisotropy;Anxiety;Area;autism spectrum disorder;Axon;biomechanical model;biomechanical test;Brain;brain abnormalities;brain morphology;Cerebral cortex;cohort;Computer Models;Computer Simulation;cortex mapping;critical period;Data;Data Set;Development;Developmental Delay Disorders;Developmental Process;Diffusion;Diffusion Magnetic Resonance Imaging;Disease;driving force;Epilepsy;Etiology;extreme prematurity;fetal;Fetal Alcohol Exposure;Fetal Development;Fetus;Future;Growth;Human;human data;Human Development;human disease;human model;Image;Impairment;in utero;Individual;Infant;innovation;Knowledge;Link;Location;longitudinal dataset;Macaca mulatta;Magnetic Resonance Imaging;Measures;mechanical force;Mechanics;Mental Depression;Mental disorders;Modeling;Morphology;Motor Cortex;multimodality;Nervous System Disorder;Neurodevelopmental Disorder;Outcome;Pattern;Play;Positioning Attribute;predictive modeling;Pregnancy;Premature Birth;Premature Infant;Radial;regional difference;Role;Schizophrenia;simulation;spatiotemporal;Stress;structural imaging;Structure;Surface;Syndrome;Testing;theories;Third Pregnancy Trimester;Time;Training;trend;Validation;Variant;white matter;Work

PROJECT_TITLE: Mechanics of Brain Folding in Human Infants Evaluated Using MRI

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Dental, Oral, and Craniofacial Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Orphan Drug;Radiation Oncology;Rare Diseases

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Narrative Proton radiotherapy is very sensitive to daily treatment setup variations and patients’ anatomical change during the treatment course. Our proposed study aims to develop an artificial-intelligent-driven online adaptive and personalized proton therapy system, which can calculate the discrepancy between the planned radiation dose and the actual dose distribution in patient’s daily anatomy before the delivery of each treatment and, if needed, generate a new plan for treatment within a few minutes. The proposed system is expected to change current clinical practice and result in a new paradigm of proton radiotherapy, ensuring that the therapeutic dose is delivered to the tumor region as desired at each treatment while minimizing treatment toxicity to improve patients’ quality of life.

PI_NAMEs: TIAN, ZHEN ;YANG, XIAOFENG  (contact)

PROGRAM_OFFICER_NAME: OKI, NOFFISAT

PROJECT_TERMS: Acute;adaptation algorithm;Address;Anatomy;Artificial Intelligence;automated segmentation;Beds;Body Weight decreased;Businesses;cancer radiation therapy;Characteristics;Clinical;clinical practice;Clinical Research;cone-beam computed tomography;cost;Data;Databases;deep learning model;deep reinforcement learning;density;Deposition;Development;direct application;Dose;dosimetry;Ensure;Equipment;Evaluation;falls;Foundations;Geometry;Goals;Head and Neck Cancer;head and neck cancer patient;Head and Neck Neoplasms;Head and neck structure;Human;Human Papillomavirus;Human Resources;Image;imaging modality;Impairment;improved;Individual;Intensity modulated proton therapy;Interruption;Intervention;Invaded;Knowledge;Life Expectancy;Magnetic Resonance Imaging;Malignant Neoplasms;Methods;Modeling;neoplastic cell;Online Systems;Organ;Overdose;overtreatment;Patients;pediatric patients;Performance;performance tests;Photons;Physicians;Physics;Population;population based;Process;Prognosis;prospective;Prospective Studies;proton therapy;Protons;Quality of life;Radiation Dose Unit;Radiation therapy;Radiation Tolerance;Resources;Risk;Support System;Survival Rate;System;Technology;technology development;Testing;Therapeutic;Three-Dimensional Imaging;Time;Tissues;tool;Toxic effect;Translations;Treatment outcome;treatment planning;Treatment-related toxicity;tumor;Variant;virtual;Work;X-Ray Computed Tomography

PROJECT_TITLE: Intelligent and Personalized Online Adaptive Proton Therapy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CTH-B (02)]


NIH_SPENDING_CATS: Genetics;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Nonembryonic - Human

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: PROJECT NARRATIVE The DNA repair protein XPC is an important regulator of somatic cell reprogramming. The overall objective of this proposal is to understand how XPC regulates TDG, an essential enzyme that removes repressive DNA methylation marks from genes, thereby activating transcription and a stem cell-like state in somatic cells. The knowledge gained will elucidate epigenetic regulation of cell state transitions, and how dysregulation of TDG-dependent pathways cause disease.

PI_NAMEs: FONG, YICK WAH (contact)

PROGRAM_OFFICER_NAME: SALAZAR, DESIREE LYNN

PROJECT_TERMS: Aberrant DNA Methylation;Acceleration;adult stem cell;Base Excision Repairs;Binding;Biochemical;Cell Lineage;Cell Reprogramming;Cells;Complex;Cytosine;Data;demethylation;Development;Disease;DNA;DNA Methylation;DNA Repair;DNA Repair Gene;Embryo;Embryonic Development;Enhancers;Enzymes;Epigenetic Process;epigenetic regulation;Excision;Family;Gene Expression;Genes;Genetic Transcription;Genome;genome-wide;genomic locus;Glycolysis;Goals;Health;HIF1A gene;Human;Hypoxia Inducible Factor;improved;induced pluripotent stem cell;innovation;Knowledge;loss of function;Measures;Metabolic;Metabolic dysfunction;Metabolism;Methylation;methylation pattern;Modeling;Mus;novel;Nucleotide Excision Repair;Outcome;oxidation;Oxidative Phosphorylation;particle;Pathway interactions;Peptide Hydrolases;Play;pluripotency;Pluripotent Stem Cells;Post-Translational Protein Processing;Process;programs;Proteins;recruit;Regulatory Element;Repair Complex;Research;response;RNA Helicase;Role;self-renewal;Signal Transduction;Somatic Cell;Specificity;stemness;Sumoylation Pathway;Testing;Thymine DNA Glycosylase;tool;Transcription Elongation;transcription factor;Work

PROJECT_TITLE: Overcoming epigenetic barriers to somatic cell reprogramming by the XPC DNA repair complex

STUDY_SECTION_NAME: Development - 2 Study Section[DEV2]


NIH_SPENDING_CATS: Biotechnology;Congenital Structural Anomalies;Genetics;Kidney Disease;Pediatric;Polycystic Kidney Disease;Rare Diseases

ORG_CITY: OKLAHOMA CITY

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PHR: PKD is a complex pathology involving interactions of multiple genes and cell types affecting the lives of millions of people. The proposed research will help disentangle some of these interactions advancing our understanding the pathophysiology of PKD and allowing the development of new, more specific, and more effective approaches to treat diseases associated with PKD.

PI_NAMEs: TSIOKAS, LEONIDAS  (contact)

PROGRAM_OFFICER_NAME: MARIC-BILKAN, CHRISTINE

PROJECT_TERMS: Adult;Affect;Age Months;Architecture;Area;Autosomal Dominant Polycystic Kidney;Autosomal Recessive Polycystic Kidney;autosome;Biochemical;Cell Culture Techniques;Cell Death;cell type;Cells;Child;Chronic Kidney Failure;Complex;Cultured Cells;Cyst;Cystic Kidney Diseases;Cystic Lesion;Data;Development;Dialysis procedure;Dilatation - action;Disease;Distal;Duct (organ) structure;Embryonic Development;Epithelial Cells;Epithelium;Experimental Genetics;experimental study;FBXW7 gene;Fibrosis;Functional disorder;Genes;Genetic;Genetic Diseases;Genetic Recombination;Growth;Henle's loop;Heterozygote;Homeostasis;improved;in vivo;infancy;Inflammation;Intervention;Joubert syndrome;Kidney;Kidney Diseases;Kidney Failure;kidney repair;Liquid substance;Meckel-Gruber syndrome;Mediating;Metanephric Diverticulum;Modeling;mouse model;Mus;mutant;Mutant Strains Mice;Names;Nephronophthisis;Nephrons;new therapeutic target;novel strategies;Null Lymphocytes;Organelles;Pathology;Patients;Persons;pharmacologic;Phenotype;Phosphotransferases;Polycystic Kidney Diseases;Process;Profibrotic signal;Proliferating;promoter;Property;Proteins;Proteome;Proteomics;receptor;Renal function;Research;RIPK3 gene;Role;Signal Pathway;Signal Transduction;Structure;System;Testing;Tissues;Transplantation;Tubular formation;Ubiquitin;ubiquitin-protein ligase

PROJECT_TITLE: Role of FBW7 in cystic diseases of the kidney

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 KUDS-L (91)]


ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: Project Narrative Botulinum neurotoxins pose a significant threat to the nation as a potential bioterrorism agent but are also widely utilized for medical treatment. Here we propose to develop novel engineered toxins to improve therapeutic efficacy for treating bladder disorders and to develop engineered antibody that can neutralize and clear toxins effectively. Our studies will improve the therapeutic use of toxins and provide effective countermeasures against the threat of these toxins.

PI_NAMEs: DONG, MIN  (contact)

PROGRAM_OFFICER_NAME: JETT, DAVID ALAN

PROJECT_TERMS: Achievement;Address;Afferent Neurons;Affinity;anti-toxin;Antibodies;antibody engineering;Bacterial Proteins;Bacterial Toxins;Binding;biodefense;Biology;Bioterrorism;Bladder Control;Bladder Diseases;Bladder Tissue;Boston;Botox;botulinum toxin treatment;Botulinum Toxins;Cardiovascular system;cost;Dangerousness;design;Development;Diffusion;Disease;Dose;drug development;Drug Kinetics;efficacy validation;engineered botulinum neurotoxins;Engineering;Environment;Equus caballus;Family;FDA approved;Funding;Goals;Grant;guinea pig model;Half-Life;Human;Immunize;improved;Intoxication;Legal patent;Licensing;Medical;Medicine;member;Modeling;Molecular;Monoclonal Antibodies;Motor;Motor Neurons;Muscle relaxation phase;Names;nanobodies;National Security;Nerve;Neurons;neurotoxicity;neurotoxin receptor;neurotransmitter release;neutralizing antibody;novel;novel therapeutics;Overactive Bladder;Pain;Paper;Paralysed;Patients;Pediatric Hospitals;Phase II Clinical Trials;Protein Engineering;Protein Isoforms;Proteins;receptor;receptor binding;Research;Rodent;Rodent Model;Sensory;Side;skeletal;Skeletal Muscle;success;synaptotagmin I;synaptotagmin II;Therapeutic Uses;tool;Toxic effect;Toxin;Toxin Conjugates;Treatment Efficacy;Urology;usability;Work

PROJECT_TITLE: Biology and Engineering of Botulinum Neurotoxins.

STUDY_SECTION: DMPB

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology B Study Section[DMPB]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Disability Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Racial and Ethnic Minority Health Research

ORG_CITY: COLUMBIA

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

ORG_STATE: SC

PHR: The proposed research is relevant to public health because it will lead to practical methods of identifying different sources of reading difficulty, including developmental language disorder (DLD), word reading difficulty (WRD), and co-occurring DLD/WRD, among Spanish-English bilingual children. This work has important implications for preventing reading difficulty prior to its onset. Therefore, this research project is aligned with the NIH’s mission to seek and apply knowledge to detect disability, to enhance the lives of children and optimize abilities for all.

PI_NAMEs: FITTON, LISA  (contact);GOODRICH, JOHN MARC

PROGRAM_OFFICER_NAME: MILLER, BRETT

PROJECT_TERMS: accurate diagnosis;accurate diagnostics;Address;Area;Assessment tool;Attention;bilingualism;Child;Child Development;Classification;Code;comprehension skill;Development;Diagnosis;Diagnostic;disability;Disease;Dyslexia;Early identification;Educational Models;elementary school;Foundations;Future;Goals;Heterogeneity;high school;implementation intervention;improved;innovation;Instruction;Intervention;kindergarten;Knowledge;Language;language comprehension;Language Development;Language Development Disorders;Language Disorders;Learning;Linguistics;Link;literacy;Measures;Methodology;Methods;Mission;Morphology;Oral;Parents;peer;prevent;Procedures;Protocols documentation;Public Health;Reading;reading ability;reading comprehension;reading difficulties;Reading Disorder;Reporting;Research;Research Project Grants;Resources;response;School Drop-Outs;Schools;second grade;Semantics;Services;skill acquisition;skills;Source;Spanish/English;spelling;Standardization;Stigmatization;Student Dropouts;Students;Subgroup;syntax;teacher;theories;Time;tool;United States National Institutes of Health;Validity and Reliability;Work

PROJECT_TITLE: Diagnostic identification of language and reading disorders among bilingual learners

STUDY_SECTION: LCOM

STUDY_SECTION_NAME: Language and Communication Study Section[LCOM]


NIH_SPENDING_CATS: Cardiovascular;Heart Disease

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: Narrative: Despite tremendous progress in treating patients with heart failure and cardiomyopathy, these diseases remain a leading cause of death across the US population. This proposal will study how natriuretic peptide signaling pathways regulate cardiomyocyte biology and test if cardiomyocyte selective targeting of these pathways can improve cardiac remodeling and reduce arrhythmia susceptibility in preclinical models of cardiomyopathy.

PI_NAMEs: BECKER, JASON  (contact)

PROGRAM_OFFICER_NAME: TJURMINA, OLGA A

PROJECT_TERMS: Angiotensin Receptor;Arrhythmia;Atrial Natriuretic Factor;Biology;Brain natriuretic peptide;Calcium;Cardiac;cardiac implant;Cardiac Myocytes;Cardiomyopathies;Cause of Death;Chemicals;Chronic;Clinical Trials;Congestive Heart Failure;CREB1 gene;Cyclic AMP-Dependent Protein Kinases;Cyclic GMP;Data;Defibrillators;Development;Dilated Cardiomyopathy;Disease;Disease Progression;end stage disease;Future;Genetic;genetic regulatory protein;Heart;Heart failure;Human;hyperkalemia;Hypotension;improved;in vivo;Individual;inherited cardiomyopathy;inhibitor;Kidney Failure;Methods;Modeling;Morbidity - disease rate;mortality;mouse model;Myocardial;Natriuretic Peptides;Neprilysin;non-genetic;NP protein;Participant;Pathologic;Pathway interactions;patient population;Patients;Peptide Signal Sequences;pharmacologic;Phosphorylation;Population;pre-clinical;Pre-Clinical Model;Predisposition;prevent;protein inhibitor of activated STAT 1;Protein Kinase;Proteins;Reducing Agents;response;Risk;Role;Secondary to;SERCA2a;side effect;Signal Pathway;Signal Transduction;small molecule;Stress;Sudden Death;Sumoylation Pathway;Testing;Therapeutic;transcription factor;valsartan;Ventricular Arrhythmia

PROJECT_TITLE: Cardiomyocyte selective modulation of natriuretic peptide signaling in cardiomyopathy

STUDY_SECTION: MPPA

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology A Study Section [MPPA]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Influenza;Nutrition;Pneumonia and Influenza

ORG_CITY: EAST LANSING

ORG_DEPT: PHARMACOLOGY

ORG_NAME: HENRY FORD HEALTH + MICHIGAN STATE UNIVERSITY HEALTH SCIENCES

ORG_STATE: MI

PHR: Despite considerable efforts toward vaccination, influenza remains a significant source of morbidity and mortality in the U.S. Our studies demonstrate that the synthetic food additive, tBHQ, impairs the T cell response to influenza; the purpose of this proposal is to determine how and why this occurs. This knowledge will allow us to better predict how tBHQ exposure will impact immunity to influenza and other respiratory viruses as well as the effectiveness of vaccination and may also allow us to predict other chemicals that may impair T cell function in a similar way.

PI_NAMEs: ROCKWELL, CHERYL ELIZABETH (contact)

PROGRAM_OFFICER_NAME: HUMBLE, MICHAEL C

PROJECT_TERMS: 2-tert-butylhydroquinone;adaptive immune response;Allergens;Anti-viral Response;Antioxidants;antiviral drug development;antiviral immunity;B-Lymphocytes;Binding;Binding Sites;Body Weight;Cause of Death;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Physiology;cell type;Cells;chemical safety;Chemicals;Critical Pathways;cytokine;Data;Development;Diet;DNA Binding;Effectiveness;effector T cell;exhaust;exhaustion;exposed human population;Exposure to;flu;Food;Food Additives;food consumption;Food Industry;Generations;Genes;Goals;Granzyme;Host Defense;Human;immune function;Immune response;Immune system;Immunity;Immunologic Memory;immunotoxicity;Impairment;In Vitro;in vivo;Individual;Influenza;Influenza A Virus, H1N1 Subtype;influenza infection;Ingredients and Chemicals;insight;inter-individual variation;Interferon Type II;Interleukin-2;Interleukin-6;Knockout Mice;Knowledge;Label;Literature;Lung;Memory;Memory impairment;Morbidity - disease rate;mortality;Mus;Nature;novel;pathogen;pathogenic virus;Persons;Pilot Projects;Pneumonia;polarized cell;Population;Process;Production;Publishing;recruit;Regulatory Pathway;Repression;Research;respiratory virus;response;Response Elements;RNA Polymerase II;Role;Safety;Severities;Source;Stress;Symptoms;T cell response;T memory cell;T-Cell Development;T-Lymphocyte;Testing;Th1 Cells;Time;TNF gene;Toxic effect;transcription factor;Transcription Initiation Site;United States Food and Drug Administration;Vaccination;vaccine efficacy;Viral;Viral Load result;Xenobiotics

PROJECT_TITLE: The role of Nrf2 in T cell function and influenza

STUDY_SECTION: EDD

STUDY_SECTION_NAME: Environmental Determinants of Disease Study Section [EDD]


NIH_SPENDING_CATS: Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Conditions Affecting the Embryonic and Fetal Periods;Contraception/Reproduction;Infectious Diseases;Maternal Health;Maternal Morbidity and Mortality;Nutrition;Obesity;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Women's Health Research

ORG_DEPT: OBSTETRICS & GYNECOLOGY

PHR: Project Narrative We previously conducted a pilot randomized placebo-controlled trial that found that the cesarean rate was lower in obese, nulliparous women who received prophylactic antibiotics during labor inductions. The currently proposed study is a multicenter trial evaluating the same intervention in that population. Should we have results similar to those in the pilot trial, prophylactic antibiotics for the indication of labor induction would represent a novel intervention to decrease the cesarean delivery rate in a group at high risk for that outcome

PI_NAMEs: PIERCE, STEPHANIE  (contact)

PROGRAM_OFFICER_NAME: LONGO, MONICA

PROJECT_TERMS: Admission activity;Affect;American;Ampicillin;Antibiotic Prophylaxis;Antibiotics;Azithromycin;biobank;Blood Transfusion;Body mass index;Cefazolin;Cesarean section;Clinical;comorbidity;Data;Dose;early onset;Endometritis;Expectancy;Funding;Future;General Population;Gestational Diabetes;high risk;high risk population;High Risk Woman;hospital readmission;Hour;Hypertension;Induced Labor;Infection;infection rate;inflammatory marker;Intensive Care Units;Intervention;intraamniotic infection;intrapartum;Intravenous;Labor Dystocia;Light;Maternal complication;maternal morbidity;microbiome;Multicenter Trials;myometrium;Neonatal;neonatal infection;neonatal morbidity;Non obese;novel;Nulliparity;Obesity;obesity prevention;Outcome;Patients;Penicillins;Pharmaceutical Preparations;pilot trial;placebo group;Placebos;Population;postcesarean section;Postpartum Hemorrhage;Pregnancy;Pregnancy Complications;pregnant;prevent;Prevention;primary outcome;prophylactic;Prophylactic treatment;Puerperal Infection;Randomized;randomized placebo controlled trial;Randomized, Controlled Trials;Regimen;Resources;Risk;Sampling;secondary outcome;stillbirth;Streptococcus Group B;Testing;Thinness;Time;Umbilical Cord Blood;Woman;Wound Infection

PROJECT_TITLE: Antibiotic Prophylaxis to Prevent Obesity-related Induction Complications in Nulliparae at Term (APPOINT 2.0)

STUDY_SECTION: PN

STUDY_SECTION_NAME: Pregnancy and Neonatology Study Section[PN]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases;Rare Diseases;Vector-Borne Diseases

ORG_CITY: BLOOMINGTON

ORG_NAME: TRUSTEES OF INDIANA UNIVERSITY

PHR: Flaviviruses such as dengue virus, West Nile virus, and Zika virus pose significant threats as emerging diseases and potential bioterror agents. We will perform integrated structural, biochemical, and virological studies to determine how flavivirus RNA genome structure influences viral replication processes. The results of our studies will lay the foundation for developing novel antiviral therapeutics to treat these currently untreatable and often deadly infectious diseases.

PI_NAMEs: CHOI, KYUNG H (contact)

PROGRAM_OFFICER_NAME: GAUTAM, RAJEEV

PROJECT_TERMS: Affect;Affinity;Anti-viral Agents;Anti-viral Therapy;antiviral drug development;Binding;Biochemical;Bioterrorism;circular RNA;Code;Communicable Diseases;Complex;Decision Trees;Dengue Virus;Disease;Double-Stranded RNA;Flavivirus;Flavivirus Infections;Foundations;Genetic Transcription;Genome;Genomics;Goals;Health;Mediating;Membrane;Modeling;Molecular;Molecular Conformation;Nonstructural Protein;novel;Polymerase;Process;promoter;Protein Biosynthesis;Proteins;recruit;Replication-Associated Process;Ribosomes;RNA;RNA chemical synthesis;RNA Viruses;Role;scaffold;Site;stem;Structure;Testing;Transcript;Transfer RNA;Translations;Vaccines;Viral;Viral Genome;Viral Nonstructural Proteins;Viral Proteins;viral RNA;Virus Replication;West Nile virus;Zika Virus

PROJECT_TITLE: MECHANISM OF RNA SYNTHESIS BY DENGUE VIRUS NS5

STUDY_SECTION: MCV

STUDY_SECTION_NAME: Molecular and Cellular Biology of Virus Infection Study Section[MCV]


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Dental, Oral, and Craniofacial Disease;Lymphatic Research;Nanotechnology;Rare Diseases

ORG_CITY: HANOVER

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: Project Narrative Head and neck tumors typically metastasize to lymph nodes at early stages of the spread of the disease. A new method to detect the presence of a small number of cancer cells in the lymph nodes could help physicians choose a more effective treatment strategy and ultimately improve survival rates.

PI_NAMEs: LUKE, GEOFFREY P. (contact)

PROGRAM_OFFICER_NAME: LOPEZ, ORLANDO

PROJECT_TERMS: Acoustics;Address;Affect;aggressive therapy;Animal Model;Antibodies;antibody conjugate;Behavior;behavior change;Binding;Biological;cancer cell;Cancer Detection;cancer type;Cell Surface Receptors;Cells;Cervical lymph node group;Characteristics;Clinical;clinical application;clinical translation;clinically relevant;Contrast Media;Deposition;design;Detection;detection limit;Diagnosis;Diagnostic Neoplasm Staging;Disease;Distant Metastasis;Drainage procedure;draining lymph node;effective therapy;Epidermal Growth Factor Receptor;Excision;Exhibits;Exposure to;Fluorescence;fluorescence imaging;Fluorocarbons;fluorophore;Focused Ultrasound Therapy;Formulation;Gases;Goals;Head and Neck Cancer;Head and Neck Neoplasms;Head and neck structure;Head Cancer;histological specimens;Image;image processing;imaging detection;Imaging Device;imaging modality;imaging system;Imaging Techniques;improved;In Vitro;Injections;Invaded;kinetic model;Kinetics;Label;Liquid substance;Lymph Node of Head, Face and Neck;lymph nodes;Lymphatic;lymphatic drainage;Magnetic Resonance Imaging;malignant mouth neoplasm;Malignant Neoplasms;Measures;Metastatic Neoplasm to Lymph Nodes;meter;Methods;Micrometastasis;migration;Miniature Swine;minimally invasive;Molecular;molecular imaging;Molecular Target;Morbidity - disease rate;Morphology;mouse model;multiplexed imaging;Mus;nanoDroplet;Neck Dissection;Neoplasm Metastasis;optical imaging;Optics;Pathologic;Patients;Pattern;Penetration;Phagocytes;phase change;Phase Transition;Physicians;Physiologic pulse;polyacrylamide;Population;Positron-Emission Tomography;prevent;Primary Neoplasm;Procedures;Prognosis;ratiometric;response;Sampling Errors;Sensitivity and Specificity;Signal Transduction;Site;Specificity;Staging;standard of care;Survival Rate;targeted agent;Techniques;Testing;Tissues;Tracer;Transducers;treatment planning;treatment strategy;tumor;Tumor Burden;Ultrasonic Transducer;Ultrasonography;ultrasound;Validation;Visualization;Work

PROJECT_TITLE: Multiplex Ultrasound Imaging for the Detection of Head and Neck Lymph Node Micrometastases

STUDY_SECTION: IPCA

STUDY_SECTION_NAME: Imaging Probes and Contrast Agents Study Section[IPCA]


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Neurodegenerative;Neurosciences;Parkinson's Disease

ORG_CITY: COLLEGE STATION

ORG_DEPT: PSYCHIATRY

ORG_NAME: TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR

PHR: Narrative: Parkinson's disease is a severe neurodegenerative disease. Current treatments are symptomatic and do not prevent disease progression. Thus, there is a need to identify new therapeutic targets. Neuroplasticity in the striatum has been found to underlie motor impairments in Parkinson's disease. However, the role of synaptic organizes in these neuroplastic changes and contribution to motor and non-motor dysfunction is not known. We propose to understand the role of a type of glutamate receptor which serves as a striatal synaptic organizer in neuroplasticity and behavioral impairment associated with Parkinson's disease.

PI_NAMEs: CHU, HONG-YUAN ;DRAVID, SHASHANK MANOHAR (contact)

PROGRAM_OFFICER_NAME: SARRAF, SHIREEN AKHAVAN

PROJECT_TERMS: 3-Dimensional;Ablation;Acute;Address;adeno-associated viral vector;AMPA Receptors;Anxiety;anxiety reduction;Axodendritic Synapse;Basal Ganglia;Behavior;Behavioral;behavioral impairment;Biochemistry;Biological;Brain;cell type;Clinical;Cognition;Complex;Confocal Microscopy;Corpus striatum structure;Data;Defect;density;Diagnosis;Disease;disease model;Disease Progression;Dopamine;Dopamine D2 Receptor;Dorsal;economic cost;Electron Microscopy;Electrophysiology (science);Equilibrium;Experimental Designs;experimental study;Frequencies;Functional disorder;Genetic;genetic approach;Genetic Models;Glutamate Receptor;Glutamates;Goals;hevin;Image;Impaired cognition;Impairment;improved;Individual;inhibitor;Injections;knock-down;Label;Laboratories;Lesion;Ligands;LoxP-flanked allele;Maintenance;member;Mental Depression;Methods;mitopark mouse;Modeling;Motor;Motor Activity;motor control;motor disorder;motor impairment;motor symptom;mouse model;Mus;N-Methyl-D-Aspartate Receptors;N-Methylaspartate;Neurodegenerative Disorders;neuroligin 1;neuroligin 3;Neuronal Plasticity;Neurons;Neurotoxins;neurotransmission;new therapeutic target;nigrostriatal degeneration;nigrostriatal dopaminergic pathway;non-motor symptom;optogenetics;Oxidopamine;Parkinson Disease;Parkinsonian Disorders;parkinsonian rodent;Pathology;Peptides;peptidomimetics;pharmacologic;Pharmacology;prevent;Property;Proteins;Reagent;receptor;Recombinant adeno-associated virus (rAAV);Recombinant Proteins;Recombinants;Research Design;restoration;Role;sex;Signal Transduction;Slice;Structure;Substantia nigra structure;symptom treatment;Synapses;synaptic function;System;Techniques;Testing;Thalamic structure;Therapeutic;Therapeutically Targetable;Time;United States;Up-Regulation;Vertebral column;vesicular glutamate transporter 2;Viral Vector

PROJECT_TITLE: Striatal Trans-Synaptic Signaling Mechanism in Parkinsonism

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: SAN JUAN

ORG_NAME: COMPREHENSIVE CANCER CENTER/ UNIV/PR

ORG_STATE: PR

PHR: Narrative The US Caribbean is vulnerable to climate change and its impact on the cancer control continuum. The Caribbean Climate Change, Cancer and Health Disparities Research Center (CCCARIB-CARES) will increase capacity at PR and USVI to develop, support, and sustain education, capacity building, research, and adaptation capacities to help mitigate the impact of climate change in cancer prevention and control and health disparities in these populations. CCCARIB-CARES will increase and support the research and governance capacity of underserved and underrepresented minorities in the Caribbean, with respect to climate change.

PI_NAMEs: MENDEZ-LAZARO, PABLO ;MICHAEL, NOREEN ;ORTIZ, ANA PATRICIA (contact)

PROGRAM_OFFICER_NAME: HALL, KARA L

PROJECT_TERMS: Address;Air Pollution;anti-cancer research;Area;Cancer Burden;cancer care;Cancer Control;cancer diagnosis;cancer health disparity;Cancer Patient;cancer prevention;cancer risk;cancer therapy;carcinogenicity;Caribbean region;Caring;Cause of Death;Cervical Cancer Screening;Child;Chronic Disease;Climate;climate change;climate crisis;climate impact;climate-related health;coal ash;Collaborations;Communication;Communities;community engagement;Community Outreach;community partners;Comprehensive Cancer Center;Continuity of Patient Care;Discipline;Division of Cancer Control and Population Sciences;Economics;Ecosystem;Education;Elderly;environment related cancer;Environmental Pollution;Environmental Risk Factor;environmental stressor;Event;Evidence based intervention;experience;Exposure to;extreme weather;Face;Faculty;Failure;Garbage;Goals;Government;Government Agencies;hazard;Hazardous Substances;Health;Health Disparities Research;health disparity;Health Priorities;high risk;Human;human centered design;Immunization Programs;Immunocompromised Host;improved;Incidence;indexing;Individual;Infrastructure;Institution;Intention;Interruption;Intervention;Island;Knowledge;landfill;Malignant Neoplasms;Medical;member;Mental Health;minority communities;Minority Groups;mortality;National Cancer Institute;Nongovernmental Organizations;Outcome;outreach;Patients;Pattern;Personal Satisfaction;Physicians;Pollution;Population;pressure;prevent;Prevention;Prevention program;Privatization;Puerto Rico;Quality of life;recruit;Research;Research Infrastructure;Research Methodology;Research Personnel;Research Project Grants;Research Support;resilience;resilience research;response;Risk;Science;screening program;social;socioeconomics;Stress;stressor;Students;superfund site;synergism;System;Training;Underrepresented Minority;underserved community;underserved minority;Underserved Population;United States National Institutes of Health;United States Virgin Islands;Universities;university student;Vaccination;Vision;Vulnerable Populations;Woman;Work

PROJECT_TITLE: The Caribbean Cancer Research Center on Environmental and Natural Hazards

STUDY_SECTION_NAME: Special Emphasis Panel[ZES1 LWJ-K (C2)]


NIH_SPENDING_CATS: Cancer;Climate-Related Exposures and Conditions;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PHR: The US Caribbean is vulnerable to natural and environmental hazards and their impact on the cancer control continuum. The Caribbean Cancer Research Center on Environmental and Natural Hazards (CARIB-CARES) will increase capacity at PR and USVI to develop, support, and sustain research, preparedness, and adaptation capacities to help mitigate the impact of natural disasters and environmental pollution on the health of the population, within the context of the cancer prevention and control continuum.

PI_NAMEs: ORTIZ, ANA PATRICIA (contact)

PROJECT_TERMS: Advisory Committees;Affect;American Cancer Society;anti-cancer research;Area;Arizona;cancer care;Cancer Center;Cancer Control;Cancer Control Research;cancer health disparity;cancer prevention;career development;Caribbean region;Climate;climate change;climate disaster;climate impact;climate-related health;Clinical Trials;Collaborations;Communication;Communities;community engagement;community organizations;Comprehensive Cancer Center;Continuity of Patient Care;coping mechanism;Development;Diagnosis;Disasters;Disparity population;Division of Cancer Control and Population Sciences;Electricity;Ensure;Event;experience;extreme heat;extreme weather;Florida;Food;Fostering;Frequencies;Funding;Goals;Health;health care availability;Health Disparities Research;health disparity;health inequalities;Health Services Accessibility;Health system;Hurricane;implementation evaluation;improved;Infrastructure;Institution;Interruption;Knowledge;Lead;Leadership;low socioeconomic status;Malignant Neoplasms;marginalized community;Medical;Migrant;Minority Groups;Mission;Monitor;National Cancer Institute;novel;outreach;Population;pressure;Principal Investigator;Process;programs;Puerto Rico;Recovery;Research;Research Personnel;Research Project Grants;response;Risk;Science;Sea;Services;Site;Students;success;Training;Training Programs;training project;United States National Institutes of Health;United States Virgin Islands;Universities;Water;West Indies

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cancer;Climate-Related Exposures and Conditions;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Social Determinants of Health

PI_NAMEs: CARDONA-CORDERO, NANCY R (contact)

PROJECT_TERMS: Acute;Address;Affect;Air;Area;burden of chronic illness;Cancer Burden;Cancer Control;cancer health disparity;Cancer Patient;cancer prevention;cancer risk;Cancer Survivor;Carcinogens;Caribbean region;Caring;Climate;climate adaptation;climate change;climate impact;Clinic;Communicable Diseases;Communities;community engagement;Complex;Continuity of Patient Care;COVID-19 pandemic;Cross-Sectional Studies;Data;Death Rate;Disaster Planning;Disparity;Droughts;economic disparity;Effectiveness;environmental disparity;Environmental Exposure;Environmental Health;Environmental Pollution;epidemiology study;Event;experience;Exposure to;extreme heat;extreme weather;Floods;Focus Groups;Food;global health;Goals;Government;hazard;Health;health care service;Health Disparities Research;Healthcare;Healthcare Systems;Housing;Human;Hurricane;Incidence;informant;Infrastructure;Intervention;Island;Knowledge;Lead;Life;Malignant Neoplasms;Maps;Methods;mortality risk;neglect;neoplasm registry;Organism;Output;Patients;Perception;Policies;pollutant;Pollution;Population;Process;promote resilience;Property;Public Health;Puerto Rico;Quality of life;Readiness;Recommendation;Recording of previous events;Research;Research Project Grants;Research Project Summaries;resilience;Risk;Risk Assessment;Sampling;sea level rise;segregation;Site;social disparities;Social Environment;Social support;Socioeconomic Status;socioeconomics;socioenvironmental factor;stressor;therapy development;underserved community;United States Virgin Islands;vulnerable community;Water

PROJECT_TITLE: Research Project


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cancer;Climate-Related Exposures and Conditions;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: MICHAEL, NOREEN  (contact)

PROJECT_TERMS: Achievement;Address;Affect;Awareness;Cancer Control;cancer health disparity;Cancer Patient;cancer prevention;cancer risk;Caribbean region;Chronic Disease;Climate;climate change;climate impact;Collaborations;Communities;community based participatory research;community engaged research;community engagement;Community of Practice;Comprehensive Cancer Center;design;Development;Dimensions;Educational Materials;Effectiveness;Environment;Environmental Pollution;Equity;Evaluation;Event;Exhibits;experience;extreme weather;Family;Friends;Goals;Health;Health Disparities Research;health disparity;health disparity populations;health equity;health equity promotion;health goals;Health Services Accessibility;Human;Human Resources;improved;Institution;interest;Island;Leadership;Linguistics;literacy;literate;Malignant Neoplasms;Measures;Medical;member;Methods;Mission;multi-ethnic;multi-racial;Multilingualism;Output;Participant;Persons;Pollution;Population;Positioning Attribute;Problem Solving;Process;Public Health;Puerto Rico;Quality of life;Readiness;Recording of previous events;Reduce health disparities;Relationship-Building;Research;Research Activity;Research Personnel;Resources;response;Risk;Risk Factors;Science;Services;social cohesion;Societies;socioeconomics;Target Populations;tool;Translations;United States Virgin Islands;Universities;Work

PROJECT_TITLE: Community Engagement Core


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Emerging Infectious Diseases;Estrogen;Infectious Diseases;Influenza;Lung;Pneumonia and Influenza;Women's Health Research

PHR: NARRATIVE Sex hormones can alter host responses and are a potential reason to why biologic males and females experience different outcomes following influenza virus infection. The proposed research will determine how estradiol, an estrogen steroid hormone, regulates lung inflammation, virus replication and other host processes during influenza virus infection in males and females. We expect to identify host responses that are differently regulated in biological males and females, which will suggest novel approaches to improve infection outcomes.

PI_NAMEs: SHOEMAKER, JASON EDWARD (contact)

PROGRAM_OFFICER_NAME: ARNOLD, MICHELLE MARIE

PROJECT_TERMS: Adult women;Adverse effects;Affect;Age Years;airway epithelium;Algorithms;Automobile Driving;Biological;Biological Response Modifiers;biological sex;bronchial epithelium;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;cytokine;Data;data modeling;Disease;Disease Outbreaks;Disease Outcome;drug candidate;Drug Targeting;Epidemiology;Epithelial Cells;Epithelium;Estradiol;Estriol;Estrogens;experience;Female;Future;Gene Expression;Gonadal Steroid Hormones;Growth;hormone regulation;Hormones;Human;human female;Immune;Immune response;Immune signaling;Immune system;Immunity;Immunologics;immunopathology;immunoregulation;improved;in silico;In Vitro;in vivo;Infection;Inflammation;Inflammatory;Influenza;Influenza A Virus, H1N1 Subtype;influenza infection;influenzavirus;Innate Immune Response;Innate Immune System;Integration Host Factors;knockout animal;Knockout Mice;Knowledge;Link;Lung;Lung immune response;Macrophage;male;mathematical model;Mediating;Modeling;Molecular;monocyte;Morbidity - disease rate;mortality;mouse model;Mus;Nasal Epithelium;Network-based;Neutrophil Infiltration;novel;novel strategies;Outcome;pandemic disease;Pathway Analysis;Pathway interactions;Patients;Pharmaceutical Preparations;phosphoproteomics;Positioning Attribute;predictive modeling;Process;Production;programs;Property;Proteins;Pulmonary Inflammation;Regulation;Regulatory Pathway;Research;respiratory;Respiratory Tract Infections;Role;seasonal influenza;Severities;sex;Sex Differences;Signal Pathway;Signal Transduction;Signaling Molecule;Signaling Protein;steroid hormone;Testing;therapy development;Time;time use;tool;transcriptomics;validation studies;Viral;Viral Load result;Virus;Virus Replication

PROJECT_TITLE: Predictive Modeling of Estradiol Effects and Sex Differences on Immunopathology during Influenza Infection

STUDY_SECTION: MABS

STUDY_SECTION_NAME: Modeling and Analysis of Biological Systems Study Section[MABS]


ORG_CITY: ITHACA

ORG_DEPT: CHEMISTRY

ORG_NAME: CORNELL UNIVERSITY

PHR: Project Narrative To assemble complex molecules rapidly, efficiently, and with predictable outcomes is among the most significant challenges in the discovery of new medicinal agents. This proposal addresses several major technological gaps in the field of organic synthesis, and its successful completion will speed the preparation of novel medicinal lead structures.

PI_NAMEs: LIN, SONG  (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TITLE: New radical-based strategies for reaction discovery

STUDY_SECTION: CSB

STUDY_SECTION_NAME: Chemical Synthesis and Biosynthesis Study Section[CSB]


NIH_SPENDING_CATS: Neurosciences;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Project Narrative: A robust and efficient vertebrate nervous system requires that axons be myelinated in the central nervous system (CNS) by myelinating glia during development and maintained and refined throughout life. However, how myelinating oligodendrocytes target specific structures and avoid others, is not known. In this proposal, using zebrafish as a vertebrate model, we will investigate the mechanisms that drive CNS myelin targeting and growth by studying junction adhesion molecules 2&3 (jams 2&3) and transmembrane protein 125b (tmem125b).

PI_NAMEs: KUCENAS, SARAH C (contact)

PROGRAM_OFFICER_NAME: TYLER, WILLIAM A

PROJECT_TERMS: Adhesions;Axon;Binding;Binding Proteins;Blood Vessels;Brain;Cell Lineage;Central Nervous System;Clustered Regularly Interspaced Short Palindromic Repeats;Data;data mining;Data Set;Dendrites;Deposition;Development;Disease;Future;Genes;Goals;Growth;Human;Image;in vivo;insight;Integral Membrane Protein;junctional adhesion molecule;Knowledge;Label;Larva;Life;Maintenance;Mediating;Mediator;Membrane;Mining;Modeling;Molecular;Multiple Sclerosis;Mus;Mutagenesis;mutant;Mutate;Mutation;Myelin;Myelin Sheath;myelination;Nervous System;neurofascin;Neuroglia;neuronal cell body;Neurons;novel;oligodendrocyte lineage;oligodendrocyte progenitor;Oligodendroglia;Organism;Pattern;Physiological;Proteins;Role;single-cell RNA sequencing;Spinal Cord;stem cells;Structure;Therapeutic;tool;Transgenic Organisms;Visualization;Zebrafish

PROJECT_TITLE: Mechanisms of CNS myelin targeting

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE  The subfamily of the tandem Coronins forms a structurally unique class among the extensive family of the Coronins, however to date their actin-regulatory functions remain completely unknown. Using a combination of single molecule techniques, protein crystallography, and cell biology, we will investigate how the mammalian tandem Coronin, Coro7, structurally and mechanistically inhibits Arp2/3-mediated nucleation induced by nucleation promoting factors (N-WASP, WHAMM, and JMY), and other Arp2/3 regulators, including GMF, and SPIN90. In addition, we will elucidate how these actin-regulatory activities of Coro7 work in concert with Arp2/3 and its various interactors in intracellular membrane transport and autophagy. Altogether, this proposal will shed light on the enigmatic actin- regulatory functions of the class of the tandem Coronins in vitro, and in cells.

PI_NAMEs: JANSEN, SILVIA  (contact)

PROGRAM_OFFICER_NAME: MASKERI, BAISHALI

PROJECT_TERMS: Actin-Binding Protein;Actins;Autophagocytosis;Biochemical;Biophysics;Cell Line;cell motility;Cells;Cellular biology;Clustered Regularly Interspaced Short Palindromic Repeats;coronin protein;Crystallography;Cues;Cytokinesis;Family;genetic regulatory protein;Glia Maturation Factor;Goals;In Vitro;insight;Intracellular Membranes;Intracellular Transport;Invaded;Knock-out;Mediating;Membrane;Microfilaments;Neoplasm Metastasis;network architecture;parent grant;Proteins;Proteomics;recruit;Regulation;scaffold;Signal Transduction;single molecule;stem;Supporting Cell;Techniques;tool;Total Internal Reflection Fluorescent;trafficking;Transmembrane Transport;Work

PROJECT_TITLE: Regulation of membrane trafficking by Coronins

STUDY_SECTION: NCSD

STUDY_SECTION_NAME: Nuclear and Cytoplasmic Structure/Function and Dynamics Study Section[NCSD]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Clinical Research;Eye Disease and Disorders of Vision;Neurosciences;Rehabilitation

ORG_CITY: BALTIMORE

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: PROJECT NARRATIVE A major constraint in treating patients with vestibular loss is the lack of objective assessments of otolith and semicircular canal function. This project investigates whether novel video-oculography (VOG) measures of vestibular function can be used as valid markers to track recovery from vestibular loss and predict functional outcomes. The findings will be crucial towards devising rehabilitation therapies based on discrete measures of vestibular function in individual patients.

PI_NAMEs: KHERADMAND, AMIR ;SCHUBERT, MICHAEL C (contact)

PROGRAM_OFFICER_NAME: KING, KELLY ANNE

PROJECT_TERMS: Acceleration;Acute;Address;Adopted;associated symptom;Blinking;Chronic;Clinical;Clinical Markers;Compensation;coping;design;Development;Dizziness;effective therapy;Equilibrium;Equipment and supply inventories;Evaluation;Excision;Frequencies;functional outcomes;Future;Gait;gaze;Grant;Head;Impairment;improved;individual patient;Judgment;kinematics;Lateral;Measurement;Measures;Methods;Modality;Motion;Neck;novel;novel marker;novel strategies;Operative Surgical Procedures;otoconia;Outcome Measure;Patients;Pattern;Perception;Posture;Predisposition;preservation;Process;Proprioception;prospective;Recovery;Rehabilitation Outcome;Rehabilitation therapy;Research;research clinical testing;response;Rotation;Saccades;Semicircular canal structure;Sensory;sensory substitution;somatosensory;standard of care;Testing;Time;Treatment Protocols;treatment strategy;Vestibular function;Vestibular loss;vestibular system;vestibulo-ocular reflex;Vision;Visual;Visual Acuity;Visuospatial;With laterality;Work

PROJECT_TITLE: Video-oculography: A novel approach towards clinical markers of vestibular function and recovery

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative High blood glucose shortly after a stroke is a frequent issue and often indicates less favorable recovery. Our research focuses on unraveling the intricate interactions between high blood glucose, red blood cells, and the consequent damage to brain blood vessels. By gaining a deeper understanding of these relationships, we aim to develop innovative approaches for diagnosis and treatment, ultimately improving the care and recovery of stroke patients.

PI_NAMEs: DENG, WENJUN  (contact);LO, ENG H.;NING, MINGMING

PROGRAM_OFFICER_NAME: BOSETTI, FRANCESCA

PROJECT_TERMS: Abnormal Red Blood Cell;Accounting;Acute;Adverse effects;antioxidant enzyme;Antioxidants;biological adaptation to stress;Blood Glucose;blood glucose regulation;Blood Vessels;brain endothelial cell;Brain Infarction;Brain Injuries;Caring;Cell Adhesion;cell injury;Cell Nucleus;cell type;Cells;Cerebral endothelium;Cerebrovascular system;Circulation;Clinical;clinical care;Clinical Research;Coculture Techniques;cohort;Diagnosis;Endothelial Cells;endothelial dysfunction;Enzymes;Erythrocyte Transfusion;Erythrocytes;Etiology;Evaluation;Exhibits;experience;Functional disorder;functional outcomes;G6PD gene;Glucose;glucose metabolism;Glutathione Disulfide;Grant;Hemoglobin;Hexosamines;Hyperglycemia;Impairment;improved;improved outcome;In Vitro;in vitro Model;indexing;Inflammation;Injury;innovation;inorganic phosphate;Insulin;Ischemic Brain Injury;Ischemic Stroke;Joints;life span;Link;Lipid Peroxidation;Mass Spectrum Analysis;Mediating;Metabolic;Modeling;Molecular;mouse model;Mus;NADP;Natural regeneration;Nature;novel;Organelles;Outcome;Oxidation-Reduction;Oxidative Stress;Pathway interactions;Patient-Focused Outcomes;Patients;Pentosephosphate Pathway;Performance;Physiological;Pilot Projects;Play;Production;Reactive Oxygen Species;Recovery;Red Blood Cell Count;repaired;Research;Resistance;response;Role;Severities;Signal Transduction;Stroke;stroke outcome;stroke patient;stroke recovery;System;Testing;Therapeutic;Time;Toll-like receptors;Translating;Translational Research;Vasodilation;Width

PROJECT_TITLE: The Role of Red Blood Cell in Stroke-Related Hyperglycemia

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


NIH_SPENDING_CATS: Cancer;Genetics;Prevention;Skin Cancer

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

PHR: NARRATIVE We have known for decades that RAS mutations drive up to a quarter of all cancers and that each tumor type is enriched for a specific set of RAS variants. Our preliminary findings suggest that specific RAS variants are enriched in melanoma because they amplify the signals required for cancer initiation in melanocytes. This proposal will use a complement of structural, biochemical, cellular, and animal studies to define the properties of RAS mutants required to initiate melanoma, and test whether interventions that target pathways that enhance these properties can prevent tumor formation.

PI_NAMEs: BURD, CHRISTIN E (contact);CAMPBELL, SHARON L

PROGRAM_OFFICER_NAME: LI, JERRY

PROJECT_TERMS: Acute Myelocytic Leukemia;Affect;Affinity;Alleles;Amino Acid Substitution;Amino Acids;Animals;Binding;Biochemical;Biochemistry;Biological;Biological Assay;biophysical techniques;BRAF gene;cancer initiation;cancer prevention;cancer type;Cell Death Induction;Cells;Clinical;Clinical Trials;Codon Nucleotides;Complement;Complementarity Determining Regions;Cysteine;Data;Dependence;Dimerization;Disparity;Drug Targeting;Elements;Exhibits;experimental study;Frequencies;Future;Goals;Growth;Guanosine Triphosphate Phosphohydrolases;high risk;Human;Immunotherapy;improved;In Vitro;in vivo;Individual;Intervention;Knowledge;KRAS2 gene;Length;Link;Malignant neoplasm of thyroid;Malignant Neoplasms;Maps;Measures;Mediating;melanocyte;Melanoma;Melanoma Cell;melanomagenesis;Mitogen-Activated Protein Kinase Inhibitor;Mitogen-Activated Protein Kinases;Modeling;Molecular;molecular dynamics;mouse model;Mus;mutant;mutant mouse model;Mutate;Mutation;Nevus;novel;Nucleotides;Oncogenic;Oncoproteins;Pathway interactions;Peptides;Pharmaceutical Preparations;pharmacologic;Phenotype;prevent;Prevention;Prevention strategy;Property;Protein Isoforms;protein protein interaction;RAS driven cancer;RAS genes;Reporter;Reporting;Research;Roentgen Rays;Signal Transduction;Skin;Structure;targeted cancer therapy;targeted treatment;Testing;thermostability;Tipifarnib;transcriptome;transcriptome sequencing;Translating;treatment response;tumor;tumorigenesis;tumorigenic;Variant;X-Ray Crystallography

PROJECT_TITLE: Molecular mechanisms of allele-specific NRAS signaling and tumorigenesis

STUDY_SECTION_NAME: Cellular Signaling and Regulatory Systems Study Section[CSRS]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Contraception/Reproduction;Genetics;Infertility;Prevention;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: PULLMAN

ORG_NAME: WASHINGTON STATE UNIVERSITY

ORG_STATE: WA

PHR: PROJECT NARRATIVE Ongoing studies demonstrate that male infertility can originate from disruptions during prepubertal development as the germline prepares for continuous sperm production. However, because the factors that regulate prepubertal germline development are largely unknown, progress towards diagnosing, preventing, or even treating male infertility has been stifled. The proposed studies will generate fundamental insights into the mechanisms that govern germ cell development, including that of the germline stem cell population and fate decisions that ultimately lay the groundwork for sperm production throughout reproductive years.

PI_NAMEs: LAW, NATHAN C. (contact)

PROGRAM_OFFICER_NAME: KENT, TRAVIS JOHN

PROJECT_TERMS: Ablation;Adult;Binding;Biological Models;Cell Lineage;Cells;Cleavage Under Targets and Release Using Nuclease;cofactor;Complex;conditional knockout;Consensus;daughter cell;Development;Diagnosis;Diagnostic;Disease;Disparate;Distal;DNA;epidemiological model;epidemiology study;Epigenetic Process;Equilibrium;Failure;Family;Fracture;Future;Genetic Transcription;Genome;genomic locus;Germ Cells;Germ Lines;germline stem cells;Goals;Human;Individual;Infertility;insight;Knowledge;Label;Lead;Longevity;male;Male Infertility;Malignant Neoplasms;Mammals;Manuscripts;member;Modeling;Modernization;Molecular;Natural regeneration;Neonatal;Play;Population;Pregnancy;prepuberty;prevent;Prevention;Process;Production;programs;Proliferating;Publishing;reproductive;Research;Role;runx proteins;RUNX1 gene;RUNX3 gene;self-renewal;single cell ATAC-seq;sperm cell;stem cell fate;stem cell function;stem cell population;stem cells;Supporting Cell;Technology;Testing;Tissues;transcription factor;Translating;Undifferentiated;Work

PROJECT_TITLE: RUNX proteins define opposing fates in the male germline

STUDY_SECTION_NAME: Development - 2 Study Section[DEV2]


NIH_SPENDING_CATS: Behavioral and Social Science;Biotechnology;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Immunization;Immunotherapy;Neuroblastoma;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Racial and Ethnic Minority Health Research;Rare Diseases;Social Determinants of Health

ORG_DEPT: PEDIATRICS

ORG_NAME: EMORY UNIVERSITY

PHR: PROJECT NARRATIVE Survival for pediatric patients with high-risk neuroblastoma remains dismal, with even worse survival for Black patients and patients who experience adverse social determinants of health like household poverty. Despite the addition of GD2 antibody immunotherapy, disparities in outcome remain, suggesting racial differences in immunity may contribute to health inequity. The goal of this proposal is to characterize tumor and host immune landscapes before and after GD2 antibody and chemotherapy combinations in newly diagnosed high risk neuroblastoma patients, and correlate results with genomic ancestry, adverse social determinants of health, and survival on a multi-institutional phase 3 clinical trial.

PI_NAMEs: DHODAPKAR, KAVITA MADHAV;GOLDSMITH, KELLY C (contact)

PROGRAM_OFFICER_NAME: HENDERSON, LORI A

PROJECT_TERMS: Adverse event;African ancestry;Antibodies;antibody immunotherapy;Antibody Therapy;antibody-dependent cell cytotoxicity;Attention;Autoimmune Diseases;Automobile Driving;Bar Codes;Biological;Biological Assay;Biological Factors;Biological Markers;black patient;Black race;Blood;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;chemotherapy;Child;Child Development;childhood cancer mortality;Childhood Extracranial Solid Tumor;Childhood Solid Neoplasm;Clinical;Combination Drug Therapy;Cytometry;cytotoxic;Data;Death Rate;Diagnosis;Disease-Free Survival;disorder risk;Disparity;disparity gap;DNA;Effector Cell;Equity;ethnic difference;Etiology;exhaust;experience;Exposure to;fitness;Future;Genetic;Genomics;Goals;health disparity;health equity;health inequalities;high risk;Household;Immune;immune cell infiltrate;immune health;Immunity;Immuno-Chemotherapy;Immunohistochemistry;Immunologic Markers;Immunologics;Immunophenotyping;Immunotherapeutic agent;Immunotherapy;improved;improved outcome;In Vitro;in vitro testing;Incidence;Income;Inequity;Infection;Infiltration;Institution;Investigation;Measures;monocyte;Mononuclear;mortality;Multi-Institutional Clinical Trial;Natural Killer Cells;Neuroblastoma;neutrophil;Newly Diagnosed;Not Hispanic or Latino;novel;nutrition;Outcome;outcome disparities;Parents;participant enrollment;patient population;Patient-Focused Outcomes;Patients;Pediatric Oncology Group;pediatric patients;Peripheral;personalized immunotherapy;phase I trial;phase II trial;Phase III Clinical Trials;phase III trial;Population;Poverty;prospective;Proteomics;Publishing;Race;racial determinant;racial difference;racial disparity;Randomized;receptor;receptor binding;Refractory;Regimen;Relapse;Reporting;response;Sampling;single cell genomics;Slice;social health determinants;standardized care;T-Lymphocyte;Testing;Toxic Environmental Substances;tumor;tumor microenvironment;tumor-immune system interactions

PROJECT_TITLE: Tumor and Host Immune signatures associated with health disparities in outcomes following GD2 immunotherapy in neuroblastoma

STUDY_SECTION: BMCD

STUDY_SECTION_NAME: Basic Mechanisms of Cancer Health Disparities Study Section[BMCD]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Dental, Oral, and Craniofacial Disease;Neurosciences;Nutrition

ORG_CITY: LOUISVILLE

ORG_NAME: UNIVERSITY OF LOUISVILLE

ORG_STATE: KY

PHR: Food consumption is an important energy regulatory function that is strongly influenced by sensory signals that originate from the oral cavity and gastrointestinal tract. This project aims to discover how molecularly defined central regulator cells contribute to sensory processing and ingestive behavior.

PI_NAMEs: BICKFORD, MARTHA E;LUNDY, ROBERT F (contact)

PROGRAM_OFFICER_NAME: SABRI, MERAV

PROJECT_TERMS: Affect;Altered Taste;Amygdaloid structure;Anatomy;Animals;Behavior;behavioral response;Brain;brain pathway;Brain Stem;Cannulas;Cell Nucleus;Cells;Citric Acid;Code;Coin;Data;Eating;Electric Stimulation;experimental study;extracellular;Feeding behaviors;Fiber Optics;food consumption;gamma-Aminobutyric Acid;Gastrointestinal tract structure;Hypothalamic structure;Implant;In Vitro;in vivo;Ingestion;Injections;insight;Intake;Interoception;Knowledge;Label;Measures;Mediating;Modeling;Molecular;Mus;Nerve;neural;neuromechanism;Neurons;Nucleus solitarius;Opsin;optogenetics;Oral;Oral cavity;oral sensory;Organism;parabrachial nucleus;Pathway interactions;photoactivation;Physiological;Physiological Processes;Pontine structure;Process;Prosencephalon;Proteins;Public Health;Quinine;response;Sensory;signal processing;Signal Transduction;Simplexvirus;Somatostatin;Source;Specificity;Stimulus;Structure;Structure of terminal stria nuclei of preoptic region;Sucrose;System;Taste Perception;taste system;transmission process;United States National Institutes of Health;Vagus nerve structure;Virus;Visceral;Water

PROJECT_TITLE: Neural Mechanisms of Ingestive Behavior

STUDY_SECTION: NIC

STUDY_SECTION_NAME: Neuroscience of Interoception and Chemosensation Study Section[NIC]


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Gene Therapy;Genetics;Immunotherapy;Neurosciences;Rare Diseases;Transplantation

ORG_CITY: PHILADELPHIA

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative In this R01 model development proposal, we plan to develop and characterize an autologous humanized mouse model for the study of immunotherapies in glioblastoma, utilizing tumor tissue and matched immune cells from the same patient. This model will incorporate an immune system, tumor model, and cell-based therapy from the same patient, removing any bias resulting from a mismatch in the immune systems and ensure experimental outcomes are relevant to the clinic. To validate the humanized model system, we will generate chimeric antigen receptor (CAR) T cells from the same patient the tumor and immune system originate from and treat the humanized mice, allowing comparison of outcomes to patient data.

PI_NAMEs: BINDER, ZEV ARI (contact)

PROGRAM_OFFICER_NAME: ZAMISCH, MONICA

PROJECT_TERMS: Address;Allogenic;Animal Model;Animals;Area;Autologous;B-Lymphocytes;bench to bedside;Biological Models;Biology;Brain Neoplasms;CAR T cell therapy;CD34 gene;cell mediated immune response;Cell Therapy;cell type;Cells;Cellular immunotherapy;Characteristics;chemokine receptor;chimeric antigen receptor;chimeric antigen receptor T cells;Clinic;Clinical Research;Clinical Trials;Cytometry;Data;Development;Engraftment;Ensure;Environment;Evaluation;exhaust;Exhibits;experience;experimental study;FOXP3 gene;Future;Glioblastoma;Goals;graft vs host disease;Hematopoietic stem cells;Human;Human Cell Line;humanized mouse;Immune;immune checkpoint;Immune response;Immune system;Immunocompetent;immunodeficiency;Immunodeficient Mouse;Immunohistochemistry;Immunotherapy;Implant;in vivo;Individual;Infusion procedures;Institution;Lead;Liquid substance;Lymphoid;Lymphoid Cell;Macrophage;Mediating;model development;Modeling;mouse model;Mus;Mutation;Myeloid Cells;Natural Killer Cells;novel;Organoids;Outcome;Patients;Pennsylvania;Play;pre-clinical;Pre-Clinical Model;pre-clinical research;preclinical development;programmed cell death protein 1;programs;Reagent;Regulatory T-Lymphocyte;response;Role;Sampling;Signal Pathway;Solid Neoplasm;Source;Study models;System;T cell infiltration;T-Lymphocyte;telomere;Testing;Therapeutic;transcriptomics;Transforming Growth Factor beta;Translating;tumor;tumor growth;tumor microenvironment;Tumor Tissue;tumor-immune system interactions;Universities;Up-Regulation;Validation;Work;Xenograft procedure

PROJECT_TITLE: Development and validation of an autologous mouse model for the study of immune interactions with glioblastoma

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CTH-D (55)]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Emerging Infectious Diseases;Infectious Diseases

ORG_DEPT: MISCELLANEOUS

ORG_STATE: NY

PHR: NARRATIVE Due to the alarming rise in antibiotic resistance development, we are in urgent need of new antibacterial therapies. Some of our most powerful current antibiotics (penicillins) are effective against bacteria because they cause unbalanced activity of “autolysins”, self-produced enzymes that kill cells by degrading the cell wall. Experiments proposed here will allow us to understand autolysins better, paving the way for new strategies to exploit bacterial self-destruction through the development of novel antibiotics that target autolysins.

PI_NAMEs: DOERR, TOBIAS  (contact)

PROGRAM_OFFICER_NAME: BOND, MICHELLE RUEFFER

PROJECT_TITLE: Molecular mechanisms of peptidoglycan endopeptidase regulation

STUDY_SECTION: PCMB

STUDY_SECTION_NAME: Prokaryotic Cell and Molecular Biology Study Section[PCMB]


NIH_SPENDING_CATS: Biotechnology;Cancer;Immunotherapy

ORG_DEPT: PATHOLOGY

ORG_STATE: OH

PHR: PROJECT NARRATIVE This proposal aims to test whether CD200R blockade, either genetically or using novel antagonist antibodies, enhances chemokine-mediated immune cell recruitment to tumors and T cell functions in tumors. We will also test if angiogenesis inhibitors will significantly increase the efficacy of CD200R blockade therapy. The information generated from this study will not only advance our understanding of cancer pathogenesis but also pave the way for human trials of CD200R blockade-based novel combination therapies.

PI_NAMEs: BASU, SUJIT  (contact)

PROGRAM_OFFICER_NAME: SALOMON, RACHELLE

PROJECT_TERMS: Address;Adoptive Transfer;Advanced Malignant Neoplasm;Affinity;angiogenesis;Angiogenesis Inhibition;Angiogenesis Inhibitors;antagonist;Antibodies;antigen-specific T cells;cancer immunotherapy;cancer infiltrating T cells;cancer therapy;CCL24 gene;CCL3 gene;CCL8 gene;CD 200;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Death;Cell Physiology;cell type;Cells;chemokine;Clinical Trials;Combined Modality Therapy;CXCL2 gene;CXCL3 gene;Development;Down-Regulation;effector T cell;efficacy testing;eosinophil;Exhibits;Gene Modified;Genetic;Goals;Human;Immune;immune cell infiltrate;immune checkpoint;immune checkpoint blockade;Immune checkpoint inhibitor;Immune Targeting;Immunologic Receptors;Immunotherapy;improved;in vivo;Infiltration;Knock-in;Knock-in Mouse;Lymphoid;Macrophage;Malignant Neoplasms;Mediating;mouse model;Mus;Myelogenous;Myeloid Cells;neoplastic cell;neutrophil;Neutrophil Infiltration;novel;Pathogenesis;Pathway interactions;Patients;Phenotype;PTPRC gene;recruit;restraint;Role;Signal Transduction;synergism;T cell therapy;T-Lymphocyte;Testing;Therapeutic antibodies;trafficking;transcription factor;Transgenic Organisms;tumor;Tumor Angiogenesis;Tumor Antigens;tumor growth;tumor microenvironment;Tumor Promotion;Up-Regulation;Vascularization;Work;XBP1 gene

PROJECT_TITLE: CD200R blockade for cancer immunotherapy

STUDY_SECTION: TIO

STUDY_SECTION_NAME: Translational Immuno-oncology Study Section[TIO]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Cancer;Cancer Genomics;Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Prevention;Social Determinants of Health

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_STATE: MD

PHR: Narrative Novel statistical methods will be developed for integrated analysis of studies with disparate data structures, such as individual-level data from a main study and summary-statistics data from genome-wide association studies. Applications will lead to understanding the mediation and effect modification of genetic associations by environmental factors, developing a comprehensive disease risk prediction model, and the powerful discovery of genetic associations for complex diseases combining different depths of phenotype data across different studies. User-friendly and computationally efficient software will be developed and freely distributed.

PI_NAMEs: CHATTERJEE, NILANJAN  (contact)

PROGRAM_OFFICER_NAME: MORALES, JOANNELLA

PROJECT_TERMS: Accounting;Algorithms;biobank;Biological Markers;Breast;Cancer Patient;cardiometabolism;causal variant;Characteristics;Cohort Studies;Complex;Complex Genetic Trait;Computational algorithm;Computer software;Computerized Medical Record;conditioning;Coronary Arteriosclerosis;COVID-19 mortality;Data;Data Analyses;data integration;Data Set;Development;Dimensions;Disease;disease diagnosis;disease model;Disease Outcome;disorder risk;Disparate;Environmental Risk Factor;epidemiology study;Estimation Techniques;gene environment interaction;Genetic;genetic association;Genetic Markers;Genetic Models;Genetic study;Genome Scan;genome wide association study;genome-wide;high dimensionality;High-dimensional Modeling;Individual;insight;interest;large scale data;lifestyle factors;Linear Models;Lung;Major Depressive Disorder;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant Neoplasms;Maps;Mediating;Mediation;Melanoma;Mental disorders;method development;Methods;model building;Modeling;Modernization;Modification;mortality risk;non-genetic;Non-Insulin-Dependent Diabetes Mellitus;novel;Outcome;Parameter Estimation;Phenotype;phenotypic data;polygenic risk score;Population;Population Heterogeneity;power analysis;pragmatic implementation;predictive modeling;Privacy;Publishing;rare variant;reference genome;research study;Risk;Risk Factors;risk prediction;risk prediction model;Sample Size;Series;sociodemographics;Software Tools;Source;Statistical Methods;statistics;Structure;Testing;theories;trait;tumor;Tumor Subtype;user friendly software;user-friendly

PROJECT_TITLE: Statistical Methods for Data Integration and Applications to Genome-wide Association Studies

STUDY_SECTION: ASPA

STUDY_SECTION_NAME: Analytics and Statistics for Population Research Panel A Study Section[ASPA]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Cannabinoid Research;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Substance Misuse

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

PHR: PROJECT NARRATIVE Sale of cannabis for recreational use is rapidly becoming legal across states in the US. Products are often marketed directly to consumers using claims that are not supported by evidence. Specifically, products are commonly labeled as “Indica”, “Sativa” and “Hybrid” and are associated with corresponding marketing claims (“Indica” products more likely to have sedative claims, e.g., relaxation, sleep; Sativa-labeled products more likely to have energizing claims, e.g., focus, productivity). The current study provides evidence to inform cannabis labeling and marketing regulations by using a large-scale content analysis of cannabis marketing and labeling, a randomized online experiment, and a placebo-controlled randomized laboratory experiment.

PI_NAMEs: MORAN, MEGHAN BRIDGID (contact);ZAMARRIPA, CARLOS AUSTIN

PROGRAM_OFFICER_NAME: ROMBERG, ALEXA RUTH

PROJECT_TERMS: Acute;Adult;Affect;Arousal;Automobile Driving;Behavior;behavioral impairment;Cannabis;cannabis administration;Cannabis policy;Cannabis retail;Cannabis sativa plant;Characteristics;Chemicals;cognitive performance;consumer product;Crossbreeding;Data;design;Development;driving performance;Drowsiness;European Economic Community;Expectancy;experience;experimental study;Feeling;Fostering;Harm Reduction;Hybrids;Impairment;improved;indexing;Knowledge;Label;laboratory experiment;Laboratory Study;Legal;marijuana use;marijuana user;Marketing;Measures;Monitor;Names;National Institute of Drug Abuse;Outcome;Participant;Patient Self-Report;Perception;Performance;Pharmaceutical Preparations;Physical activity;Placebo Control;Placebo Effect;Placebos;Plants;Policies;Prevalence;Product Labeling;Productivity;Public Health;Randomized;Recreation;Regulation;Relaxation;Reporting;Research;Risk;risk perception;Sales;Sampling;Scientist;Sedation procedure;sedative;Sleep;Smoke;Specific qualifier value;Terpenes;Testing;Therapeutic;Time;Tobacco;Translating;willingness;Work

PROJECT_TITLE: Effects of Cannabis Species Labeling and Marketing on Perceptual, Subjective and Objective Use Outcomes

STUDY_SECTION: LHB

STUDY_SECTION_NAME: Lifestyle and Health Behaviors Study Section[LHB]