PI_NAMEs: HANSEN, MALENE  (contact)

PROJECT_TERMS: Adherence;Age;Aging;analysis pipeline;Applications Grants;Artificial Intelligence;Atlases;Award;Biological;Biological Markers;Breast;candidate marker;Cell Aging;Collaborations;Communication;Data;data access;data acquisition;Data Analyses;data analysis pipeline;Data Coordinating Center;data quality;data resource;data sharing;data submission;design;Development;Drug or chemical Tissue Distribution;Ensure;experimental study;frailty;Funding;Gene Expression Profile;Goals;Guidelines;Human;Human Resources;human tissue;improved;instrumentation;Knowledge;knowledge base;Leadership;Mammary Gland Parenchyma;Maps;meetings;member;muscle aging;new technology;novel;Ovary;Pilot Projects;Policies;Procedures;Proteomics;Protocols documentation;Quality Control;Reporting;Reproducibility;reproductive;Research;Research Activity;Research Personnel;Resources;Scientist;senescence;senescent cell;Site;Skeletal Muscle;skills;Specimen;success;synergism;Technology;technology development;Tissue Banks;tissue mapping;Tissues;tool;Training;transcriptome sequencing;transcriptomics;Travel;United States National Institutes of Health;Validation;Visit;Work

PROJECT_TITLE: Senescence tissue mapping and SASP Atlas for human somatic and reproductive tissues

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-D]


ADMINISTERING_IC: LM

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Bioengineering;Brain Disorders;Cancer;Clinical Research;Data Science;Intellectual and Developmental Disabilities (IDD);Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD)

ORG_CITY: BOSTON

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: NORTHEASTERN UNIVERSITY

ORG_STATE: MA

PHR: RELEVANCE (See instructions):  Individuals with ASD who are severely impacted and engage in challenging behavior are understudied  and underserved. Our prior work combined with the data and methods produced in this project will lay the  foundation for expanding data collection on precursor behaviors associated with challenging behavior and  future development of just-in-time adaptive intervention (JITAI) mobile health systems (mHealth) that  enable new opportunities for intervention.

PI_NAMEs: GOODWIN, MATTHEW SCOTT (contact)

PROGRAM_OFFICER_NAME: REDDY, GOUTHAM

PROJECT_TERMS: adaptive intervention;Address;Adoption;adverse outcome;Age;Aggressive behavior;algorithmic methodologies;Algorithms;Area;autism spectrum disorder;Behavior;Behavioral;behavioral health;Biometry;Biosensor;Calibration;Cardiovascular system;Childhood;Clinical;cloud based;computer human interaction;contextual factors;Data;Data Collection;data modeling;Decision Making;Detection;Development;digital data;Disease;emotion dysregulation;Event;Face;Fingerprint;Foundations;Future;Gestures;health application;Health Care Costs;health care service;Health system;High Prevalence;Human;improved;Individual;individuals with autism spectrum disorder;innovation;Instruction;Intensive Care Units;Internet;Intervention;Label;life-long learning;Machine Learning;Mediating;Methods;mhealth interventions;Modality;Modeling;Nature;Network-based;neural network;Neural Network Simulation;novel;Participant;Performance;personalized intervention;Physical activity;Physiological;Population;practical application;predictive modeling;Procedures;Process;prospective;psychiatric inpatient;Research;Seizures;Self-Injurious Behavior;Services;Signal Transduction;social;Speech;speech recognition;statistics;success;supervised learning;support vector machine;Techniques;Technology;Testing;theories;Time;transfer learning;Triage;Universities;Validation;wearable sensor technology;Work

PROJECT_TITLE: SCH: Enhancing Automated Prediction of Challenging Behavior in Individuals with Autism Using Biosensor Data and Machine Learning

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-VH-N(50)R]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Dissemination and Implementation Research;Health Services;Mental Health;Physical Injury - Accidents and Adverse Effects;Prevention;Social Determinants of Health;Violence Against Women;Violence Research;Women's Health Research

ORG_CITY: ATLANTA

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE This project will be the first to compare lower-intensity (standard) and higher-intensity implementation strategies to deliver GlobalConsent—an efficacious web-based sexual-violence prevention program—to men attending six universities across Vietnam. Following a rigorous, mixed-methods, comparative interrupted-time-series design, we will collect novel data to compare implementation fidelity, drivers and outcomes, effectiveness, and cost- effectiveness across implementation strategies groups. Our partnership includes universities also engaged in a violence-prevention training grant (D43TW012188), offering an unparalleled opportunity for capacity strengthening and evidence generation to guide national leaders on best strategies for launching GlobalConsent at scale, to address a gendered risk factor in adolescence, and thereby, improve an array of health outcomes into adulthood.

PI_NAMEs: YOUNT, KATHRYN M (contact)

PROGRAM_OFFICER_NAME: CAMPBELL-ROSEN, HOLLY RENEE

PROJECT_TERMS: Acute;Address;Adherence;Adolescence;Adoption;Adult;Affect;Affective;Aftercare;Asia;Attention;Attitude;Behavior;behavior change;Behavioral;behavioral health;Belief;Chronic;college;comparative;comparative cost effectiveness;compare effectiveness;Consent;cost;cost effective;cost effectiveness;cost-effectiveness evaluation;Country;Data;design;Drama;Education;Education and Outreach;Effectiveness;effectiveness outcome;Eligibility Determination;Empathy;Etiology;evidence base;experience;Exposure to;Faculty;Focus Groups;follow-up;Forcible intercourse;Fostering;Gender;Generations;Grant;Health;health inequalities;implementation barriers;implementation facilitators;implementation fidelity;implementation strategy;implementation trial;implementation/effectiveness;improved;Incentives;Income;informant;innovation;Institution;Interruption;Interview;Knowledge;Leadership;Learning;Learning Module;Link;low and middle-income countries;male;Manuals;Mediator;Medical;men;Mental Health;Methods;Modification;North Vietnam;novel;online delivery;Online Systems;Outcome;outreach;peer;Penetration;Perception;perpetrators;Persons;physical conditioning;post implementation;post intervention;prevent;Prevention program;Primary Prevention;programs;Qualitative Research;Randomized;Reach, Effectiveness, Adoption, Implementation, and Maintenance;remote delivery;Reporting;Research;Research Priority;Risk;Risk Factors;scale up;Series;Sex Behavior;sexual debut;sexual violence;Sexual violence prevention;Societies;Students;Surveys;synergism;Techniques;Testing;theories;Time;Training;Training Programs;Universities;university student;Vietnam;Violence;violence prevention;Woman

PROJECT_TITLE: SCALE: Strategies for Implementing GlobalConsent to Prevent Sexual Violence in University Men

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HSS-G(50)R]


ADMINISTERING_IC: AG

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Breast Cancer;Cancer;Cancer Genomics;Clinical Research;Contraception/Reproduction;Genetics;Human Genome;Infertility;Sarcopenia;Women's Health Research

ORG_CITY: NOVATO

ORG_NAME: BUCK INSTITUTE FOR RESEARCH ON AGING

ORG_STATE: CA

PI_NAMEs: DUNCAN, FRANCESCA E. (contact)

PROJECT_TERMS: Adult;Affect;Age;age related;age related decline;age-related muscle loss;Aging;aging clocks;Assisted Reproductive Technology;Automobile Driving;Bar Codes;Bilateral;Biological;Biological Markers;Biological Specimen database;Biopsy;Biopsy Specimen;Breast;Breast biopsy;Breast Diseases;Calibration;CDKN2A gene;Cell Aging;Cells;Certification;chemokine;Chronic;Chronology;Clinical;Clinical Data;Complex;Consent;Creatine;cytokine;Data;Data Analyses;Dedications;Development;Disease;DNA Methylation;egg;Endometrial Hyperplasia;endometriosis;epigenetic aging;epigenetic clock;Evaluation;Exhibits;experimental study;Exposure to;Fatty acid glycerol esters;Female;Female breast;female reproductive system;first-in-human;Follicular Fluid;frailty;Freezing;Future;Gene Expression;Goals;Growth Factor;Health;health data;Human;Human body;human tissue;Infertility;Inflammation;Informed Consent;insight;Institutional Review Boards;life span;Liquid substance;male;Malignant Breast Neoplasm;Mammary Gland Parenchyma;Maps;Mass Spectrum Analysis;Measurement;Mendelian disorder;Microscopic;Mitotic;Molecular;Muscle;muscle form;Muscle function;muscle progenitor cell;Muscular Atrophy;Neoplasms;novel;Organ;Outcome;Ovarian;Ovarian Diseases;Ovarian Tissue;Ovary;Pathologic;Pathologist;Peptide Hydrolases;Physical Performance;Plasma;Positioning Attribute;Procedures;Process;prospective;Proteomics;Protocols documentation;Ptosis;reproductive;reproductive function;reproductive organ;Resolution;risk prediction;Salpingo-Oophorectomy;Sampling;sarcopenia;Secure;senescence;senescence associated secretory phenotype;senescent cell;senolytics;Series;sex;single nucleus RNA-sequencing;Skeletal Muscle;Source;Specimen;Sterility;Stimulus;Structure;Technology;Testing;Time;Tissue Banks;tissue mapping;Tissues;tool;transcriptomics;Universities;Urine;Validation;vastus lateralis;virtual;Woman

PROJECT_TITLE: Biospecimen Core for Procurement of Human Somatic and Reproductive Tissues for Senescent Cell Mapping


NIH_SPENDING_CATS: Aging;Clinical Research;Genetics;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

PI_NAMEs: FURMAN, DAVID  (contact)

PROJECT_TERMS: advanced analytics;Age;age related chronic disease;age-related disease;Aging;Algorithms;Animal Model;Apoptosis;Apoptotic;artificial intelligence method;Atlases;Biological;Biological Markers;Blood;Breast;Cardiovascular Pathology;Cell Aging;Cell Nucleus;Cell Physiology;Cells;Chronic Disease;clinical phenotype;Collaborations;Communities;Data;Data Analyses;data analysis pipeline;Data Coordinating Center;data infrastructure;Data Set;data sharing;data visualization;Databases;Development;Diagnostic;Diagnostic Procedure;diagnostic tool;Disabling;disease phenotype;drug development;Drug Targeting;Early Diagnosis;Ensure;ethical, legal, and social implication;experience;Exposure to;Eye diseases;Female;Follicular Fluid;frailty;Future;Gene Expression;Gene Expression Profile;Generations;genetic signature;Genotype;Goals;Health;healthspan;Hematological Disease;Human;Human body;human tissue;Image;improved;in vivo;Individual;Inflammation Mediators;Inflammatory;Kidney Diseases;Link;Liquid substance;Liver diseases;Lung Diseases;Machine Learning;Mammary Gland Parenchyma;Maps;Measures;Metabolic Diseases;method development;Methods;Molecular;Morphology;Muscle;Musculoskeletal Diseases;neuropsychiatry;novel;novel therapeutics;Ovary;Participant;Phenotype;Plasma;Population;predictive tools;preservation;prevent;Primary Cell Cultures;Procedures;Process;Production;Proteome;proteomic signature;Proteomics;Protocols documentation;Public Health;Quality Control;reproductive;reproductive longevity;Research;Research Personnel;Resources;Risk;Sampling;screening;senescence;senescent cell;senolytics;single nucleus RNA-sequencing;skin disorder;Specificity;Stains;Statistical Methods;stressor;Surrogate Markers;System;targeted treatment;Techniques;technology platform;Tissue Banks;tissue mapping;Tissues;transcriptomics;Urine;Validation;Visualization;Work

PROJECT_TITLE: Leveraging Multi-Scale Deep Phenotyping and Applied Machine Learning to Predict Senescent Cell Burden in Humans


NIH_SPENDING_CATS: Aging;Biotechnology;Clinical Research;Contraception/Reproduction;Genetics;Women's Health Research

PI_NAMEs: MELOV, SIMON  (contact)

PROJECT_TERMS: Age;age related;Aging;Atlases;Automobile Driving;Back;Biological;Breast;Cell Aging;Cell Culture System;Cell Culture Techniques;Cell Nucleus;cell preparation;cell type;Cells;Characteristics;Collaborations;Complex;Custom;Data;Data Analyses;Data Set;design;digital;Emerging Technologies;Encapsulated;Ensure;epigenetic aging;epigenetic clock;Experimental Models;experimental study;Female breast;female reproductive system;Follicular Fluid;Freezing;Frequencies;Gene Expression Profile;Gene Expression Profiling;Goals;Health;Histologic;Human;human female;human tissue;Knowledge;Liquid substance;Mammary Gland Parenchyma;Maps;Mass Spectrum Analysis;Messenger RNA;Monitor;Muscle;muscle progenitor cell;muscular system;nano-string;novel;Organ;Outcome;Outcome Study;Ovary;Plasma;Prevalence;Procedures;Process;protein profiling;Proteins;reproductive;reproductive senescence;Role;sarcopenia;senescence;senescence associated secretory phenotype;senescent cell;senolytics;sex;Sex Differences;single nucleus RNA-sequencing;Skeletal Muscle;skeletal muscle wasting;spatial relationship;Techniques;Technology;therapeutic development;therapeutic target;tissue biomarkers;tissue culture;tissue mapping;Tissues;transcriptomic profiling;Urine;Validation;whole genome;Work

PROJECT_TITLE: Mapping and validating senescent cells in human muscle, ovary and breast


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Emerging Infectious Diseases;Infectious Diseases;Kidney Disease;Precision Medicine;Prevention

ORG_CITY: Bangkok

ORG_COUNTRY: THAILAND

ORG_FIPS: TH

ORG_NAME: CHULALONGKORN UNIVERSITY

PHR: PROJECT NARRATIVE Leptospirosis is a significant global human health problem that causes fulminant liver dysfunction, kidney failure, and severe pulmonary hemorrhage. Our long-term goal is to identify predictive biomarkers for severe acute leptospirosis and its long-term sequelae.

PI_NAMEs: SRISAWAT, NATTACHAI  (contact)

PROGRAM_OFFICER_NAME: MUKHOPADHYAY, SUMAN

PROJECT_TERMS: Acute;Acute Renal Failure with Renal Papillary Necrosis;Adverse event;adverse outcome;Age;analytical method;Antibiotic Therapy;Area;biobank;Biological Assay;Biological Markers;biomarker identification;Blood specimen;Caring;Characteristics;Chronic Kidney Failure;Clinical;Clinical Data;clinical database;clinical predictors;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;Cohort Studies;Collaborations;comorbidity;cytokine;Data;Databases;demographics;Diagnosis;Diagnostic;Diagnostic tests;Dialysis procedure;Disease;Disease Progression;Early Diagnosis;Enrollment;Epidemiology;experience;Fever;follow-up;Frequencies;Gene Expression;Goals;Health;Hemorrhage;Hospitals;Human;Immune response;Immunoglobulin M;improved;improved outcome;innovation;inorganic phosphate;Inpatients;Interleukin-6;isothermal amplification;Kidney;Kidney Failure;Laboratories;LCN2 gene;Leptospirosis;Life;Liver Dysfunction;Liver Failure;long-term sequelae;Longitudinal Studies;Longterm Follow-up;Lung;Machine Learning;Magnesium;MicroRNAs;Molecular;mortality;multiple omics;Multiple Organ Failure;nano-string;novel;novel marker;Outcome;Outpatients;Patient Recruitments;Patients;Performance;Phase;Plasma;point of care;Polymerase Chain Reaction;Population;Positioning Attribute;predictive marker;Principal Investigator;progression risk;prospective;Proteins;Proteomics;Province;Publishing;Rapid diagnostics;Recovery;Reporting;Research Personnel;Resource-limited setting;Risk;Risk Factors;Sampling;Sepsis;Serology test;Severities;Severity of illness;sex;Site;Survivors;systemic inflammatory response;Thailand;Time;wasting

PROJECT_TITLE: Identification of predictive biomarkers for severe acute leptospirosis and its long-term sequelae

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 SAS-W (J1)]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

ORG_CITY: NAIROBI

ORG_COUNTRY: KENYA

ORG_FIPS: KE

ORG_NAME: KENYATTA  NATIONAL  HOSPITAL

PHR: NARRATIVE Kenyatta National Hospital (KNH) has an established grants management system that has limited capacity to support pre-award grants management processes for the researchers in the institution. This application proposes to create pre-award grants management processes at Kenyatta National Hospital (KNH) and other local institutions by leveraging the existing >35 years collaborative partnership with the University of Washington (UW). This will be achieved by training two senior KNH administrators through hands-on training at UW and NIH, who will then facilitate development of institutional pre-award processes, and building capacity of other research administrators at KNH and other Kenyan institutions that receive NIAID funds through job training, mentorship, and participation in research administrators’ community of practice.

PI_NAMEs: KINUTHIA, JOHN ;NZOVE, EMMACULATE MUKENYI (contact)

PROGRAM_OFFICER_NAME: MOITRA, KAROBI

PROJECT_TERMS: Address;Administrator;Affect;Area;Award;Benchmarking;career;Caring;Clinical Research;clinical research site;Collaborations;Communities;Community of Practice;Country;Databases;Development;Doctor of Philosophy;Educational process of instructing;Educational workshop;Ensure;Equity;experience;Federal Government;Fogarty International Center;Funding;global health;Government regulations;Grant;Growth;Guidelines;health equity;Health Planning;Health Policy;Hospital Administrators;Hospital Referrals;Hospitals;Human Resources;improved;Inservice Training;Institution;Instruction;International;Kenya;Knowledge;Learning;Link;Maps;Medical;Mentorship;Modeling;National Institute of Allergy and Infectious Disease;Occupations;Persons;Policy Developments;Procedures;Process;programs;Public Health;Research;Research Activity;Research Methodology;Research Personnel;Research Project Grants;Research Proposals;Research Training;Resources;Scholars Program;skills;Specialist;success;System;Trainers Training;Training;Training Programs;Training Support;United States National Institutes of Health;Universities;virtual;Washington;Work;Writing

PROJECT_TITLE: Strengthening pre-award grants management at Kenyatta National Hospital (KNH)

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 NKD-D (J2)]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Brain Disorders;Breastfeeding, Lactation and Breast Milk;Clinical Research;Depression;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Lung;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Nutrition;Orphan Drug;Pediatric;Pediatric - AIDS;Pregnancy;Prevention;Rare Diseases;Tuberculosis;Women's Health Research

ORG_CITY: CAPE TOWN

ORG_COUNTRY: SOUTH AFRICA

ORG_FIPS: SF

ORG_NAME: MEDICAL RESEARCH COUNCIL OF SOUTH AFRICA

PHR: PROJECT NARRATIVE Very few pregnant women were included in the clinical trials of a new all-oral 6-month regimen for the treatment of RR-TB. In the proposed study we will: 1) compare adherence to this new regimen in pregnant and non-pregnant women; 2) determine if there is an association with depression, especially in the postpartum period; and 3) explore the effect of pregnancy on the exposure of drugs in this regimen and determine the concentrations of these drugs in breastmilk and breastfed infants.

PI_NAMEs: LOVEDAY, MARIAN  (contact)

PROGRAM_OFFICER_NAME: LAUGHON, BARBARA E

PROJECT_TERMS: Adherence;adverse pregnancy outcome;antenatal;antiretroviral therapy;Breast Feeding;Breastfed infant;Cessation of life;child bearing;clinical decision-making;Clinical Trials;cohort;Communicable Diseases;Data;Depression screen;Development;Dose;drug clearance;Drug Exposure;Drug resistance in tuberculosis;drug use in pregnancy;effective therapy;electronic adherence monitoring;Enrollment;Essential Drugs;Evidence based intervention;Excretory function;Exposure to;Guidelines;Health Personnel;HIV;HIV/TB;Hospitalization;Human Milk;improved;Incidence;Individual;Infant;Intervention;Lactation;Late pregnancy;Levaquin;Linezolid;Maternal Health Services;maternal morbidity;Maternal Mortality;maternal risk;Measures;medication compliance;Mental Depression;Mental Health;Modeling;Monitor;monitoring device;Nausea and Vomiting;novel;novel therapeutic intervention;Oral;Persons;Pharmaceutical Preparations;Physiological;Pilot Projects;Plasma;Population;Postpartum Depression;Postpartum Period;Postpartum Women;Pregnancy;pregnant;Pregnant Women;Preventive therapy;prospective;Public Health;Published Comment;Recommendation;Regimen;Reporting;Resistance development;Rifampicin resistance;Risk;Safety;Sampling;Screening procedure;South Africa;South African;Therapeutic;Therapeutic Intervention;Third Pregnancy Trimester;Toxic effect;transmission process;treatment adherence;treatment duration;Treatment Failure;Treatment outcome;Treatment Protocols;treatment strategy;Tuberculosis;tuberculosis drugs;tuberculosis treatment;Woman;women's treatment;World Health Organization

PROJECT_TITLE: IMPILO: Investigating novel 6-Month regimens for RR-TB in Pregnancy and Lactation


ADMINISTERING_IC: GM

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Urologic Diseases

ORG_CITY: PALO ALTO

ORG_NAME: PHINOMICS INC.

PHR: NARRATIVE Extrachromosomal circular DNA (eccDNA) elements are known to play a role in a variety of normal and pathological cellular processes; however, isolating and characterizing different classes of eccDNA to determine their role in these processes is a unique challenge. To address this, Phinomics is developing an innovative, unbiased technology that provides a comprehensive toolkit to isolate every size of eccDNA molecules in an intact state suitable for next-generation sequencing together with a suite of biophysical and novel bioinformatic methods to characterize these molecules. Surveillance based on eccDNA biomarkers is aimed at a minimally invasive strategy to determine the immune response to therapies, predict recurrence likelihood, and monitor residual disease.

PI_NAMEs: SHOURA, MASSA  (contact)

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TERMS: Address;Antibiotics;Area;Biogenesis;Bioinformatics;bioinformatics pipeline;Biological;Biological Markers;biomarker identification;Biophysics;Biopsy;Bladder Neoplasm;cancer biomarkers;Cancer cell line;cancer diagnosis;Cancer Diagnostics;cancer therapy;Cell Line;Cell Physiology;Cells;Circular DNA;CLIA certified;commercialization;Copy Number Polymorphism;cost effective;Data;detection sensitivity;Diagnostic;Disease;DNA;DNA Markers;DNA Sequence;DNA Structure;Double Minutes;Drug resistance;Elements;environmental adaptation;Epigenetic Process;extrachromosomal DNA;functional genomics;Genome;Genomics;Glioblastoma;Goals;High-Throughput Nucleotide Sequencing;Human;Human Cell Line;human disease;Human Pathology;Immune response;Informatics;innovation;Knowledge;liquid biopsy;Liquid substance;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Maps;Marketing;meetings;Methods;microbiome analysis;minimally invasive;Molecular;molecular size;Monitor;Muscle;new technology;next generation sequencing;Noise;non-muscle invasive bladder cancer;novel;Outcome;Pathologic;Pathway interactions;Patients;Performance;Peripheral Blood Mononuclear Cell;Phase;Plasma;Population;Prediction of Response to Therapy;Process;Property;prototype;Recurrence;repository;Reproducibility;Residual Neoplasm;Resistance;Role;Sampling;Signal Transduction;Small Business Innovation Research Grant;Solid;Somatic Cell;Specificity;Structure;Technology;technology platform;Testing;Tissues;translational potential;tumor;Urine;vaccine development;Validation

PROJECT_TITLE: Novel Technologies to Isolate and Analyze Extrachromosomal DNAs for Diagnostic Applications


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_CITY: AUSTIN

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

ORG_STATE: TX

PHR: OVERALL: PROJECT NARRATIVE With infrastructure support from the Population Dynamics Branch of NICHD, the Population Research Center at The University of Texas at Austin aims to advance public health understanding of the social, structural, and contextual processes underlying population health and health disparities.

PI_NAMEs: GERSHOFF, ELIZABETH T. (contact)

PROGRAM_OFFICER_NAME: CLARK, REBECCA L

PROJECT_TERMS: Address;Area;Award;Behavioral;career;catalyst;Collaborations;Communities;Data;data access;data centers;Data Collection;Data Science;Development;Education;Educational workshop;experience;Faculty;falls;Family Demographies;Feedback;Fostering;Funding;Grant;Health;health disparity;health inequalities;Human;Human Development;Infant Health;Infrastructure;innovation;Institution;Maternal Health;meetings;member;Mentored Research Scientist Development Award;Mentors;Mission;National Institute of Child Health and Human Development;Newsletter;next generation;Peer Review;Personal Satisfaction;Population;Population Dynamics;population health;Population Research;Process;Productivity;programs;Public Health;Reproductive Health;Research;Research Infrastructure;Research Personnel;Research Project Grants;Research Support;Resource Sharing;Resources;scaffold;Scholars Program;Scientist;Series;Services;social;Social Problems;statistics;Strategic Planning;symposium;System;Technology;Texas;Time;Translating;United States National Institutes of Health;Universities;visiting scholar;Work;Writing

PROJECT_TITLE: Population Research Center

STUDY_SECTION_NAME: Special Emphasis Panel[ZHD1 DSR-K (55)]


PROJECT_TERMS: Academia;Acceleration;Accounting;Address;Administrative Efficiency;Award;catalyst;Collaborations;Communities;Development;experience;Faculty;Family;flexibility;Fostering;Goals;Grant;Hispanic-serving Institution;Historically Black Colleges and Universities;Human Resources;Infrastructure;innovation;interest;meetings;member;Mentors;Newsletter;next generation;operation;Policy Maker;Population;Population Dynamics;Population Research;Population Sciences;Productivity;programs;Publishing;Reader;Reporting;Research;Research Activity;Research Peer Review;Research Personnel;research study;Research Support;Scholars Program;Scientist;Series;Service provision;Services;social media;social science research;success;symposium;Texas;Training Programs;Translations;Travel;Universities;visiting scholar;web site

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Clinical Research

PI_NAMEs: GLASS, JENNIFER L (contact)

PROJECT_TERMS: Applications Grants;Award;catalyst;Collaborations;college;Development;Discipline;distraction;Educational workshop;Eligibility Determination;Ensure;experience;Faculty;faculty mentor;faculty support;Feedback;Fostering;Funding;Funding Agency;Goals;Grant;Grant Review;innovation;interdisciplinary collaboration;interest;Investments;Journals;Manuscripts;meetings;Mentored Research Scientist Development Award;Mentors;Mission;Participant;peer;Population Dynamics;Population Research;Population Sciences;Postdoctoral Fellow;Process;programs;Publishing;Research;Research Personnel;Resource Sharing;Schools;Secure;Services;Source;Students;success;Texas;United States National Institutes of Health;Universities;Writing

PROJECT_TITLE: Development Core


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Data Science;Networking and Information Technology R&D (NITRD)

PI_NAMEs: CALDER, CATHERINE A (contact)

PROJECT_TERMS: Arts;Awareness;Behavioral;Biological Markers;cloud storage;Collaborations;college;community center;Complement;computer infrastructure;Country;Creativeness;Data;data access;Data Analyses;data centers;Data Collection;data enclave;data infrastructure;data management;Data Science;Data Set;Data Storage and Retrieval;data visualization;Development;Devices;Ecological momentary assessment;Education;Educational workshop;Ensure;Faculty;faculty research;faculty support;Fees;Financial Support;Funding;Information Technology;Infrastructure;innovation;Institution;Leadership;live stream;Machine Learning;medical schools;Methodology;Methods;National Longitudinal Survey of Adolescent to Adult Health;Natural Sciences;novel;Online Systems;Population;Population Dynamics;Population Research;Population Sciences;Population Study;Publications;Recovery;Research;Research Infrastructure;Research Institute;Research Methodology;Research Personnel;Research Support;Resources;Risk;Scholarship;Secure;Security;Series;Services;social;Speed;Statistical Computing;Statistical Data Interpretation;statistics;Strategic Planning;success;Support System;System;Technology;Texas;Universities;virtual;Vision;Visual;Visualization;web services

PROJECT_TITLE: Scientific and Technical Core


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Rare Diseases

ORG_CITY: JOS

ORG_COUNTRY: NIGERIA

ORG_FIPS: NI

ORG_NAME: JOS UNIVERSITY TEACHING HOSPITAL

PHR: Project Narrative Global Infectious Disease Research Administration Develop Program for Low-and-Middle-Income Countries is an intervention to increase the capacity of Research Administrators and Finance Managers of NIAID/NIH projects to support the mission of the institute in ameliorating infectious diseases in the world. This investment by the institute has rippling positive effects, on not only the prime institution, but also other local in-country institutions as well as regional institutions; through this, information of funding opportunities for health research, establishing grant management offices, and strengthening existing ones, has been implemented. It has brought great awareness to the business of grants administration, among Faculty Researchers, and institution management support for new policies and procedures for the implementation of external funding; it has also impacted on internal funding operations, for global health or social researches, by other international or local funders.

PI_NAMEs: KPARMAK, MARK GWAMZING (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Acute;Administrator;Affect;Africa;African;Agency for International Development;anti-cancer research;Applications Grants;Arboviruses;Attention;Award;Awareness;Benin Republic;Bilateral;biomedical scientist;burden of illness;Businesses;Centers for Disease Control and Prevention (U.S.);Collaborations;college;Communicable Diseases;Communities;cost effective;Country;Data;Development;Disease;Disease remission;Electronics;Emergency Situation;Emerging Communicable Diseases;Epidemiology;Faculty;Family;Fogarty International Center;follow-up;Foundations;Funding;Funding Agency;Funding Opportunities;global health;Goals;Government;Grant;Guidelines;Health;Health Sciences;hearing impairment;Hemorrhage;improved;Infectious Diseases Research;Information Technology;Institution;interest;International;Intervention;Investments;Lassa Fever;Lassa virus;low and middle-income countries;Medical;Medical Microbiology;Mentors;Michigan;Mission;National Institute of Allergy and Infectious Disease;Neurologic;New York;Nigeria;Office Management;online resource;operation;Pathogenicity;payment;Performance;Persons;Phase;Physicians;Policies;Positioning Attribute;Pregnancy;Pregnant Women;Preparation;Prevention;Procedures;programs;prospective;Public Health;Reporting;Research;research and development;Research Institute;Research Personnel;Risk;Schools;Services;Sierra Leone;social;success;System;Teaching Hospitals;Texas;Togo;tool;Training;training project;United States National Institutes of Health;Universities;University adminstration;virtual;Work;Zika Virus;Zoology;Zoonoses

PROJECT_TITLE: Michigan-Unijos Mentored Program for Enhanced Research Administration (MUMPERA)


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: LEXINGTON

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: PROJECT NARRATIVE Colorectal cancer is the second most common cause of cancer death in the U.S. Increased FASN-dependent de novo lipid biosynthesis drives tumorigenesis and progression. Our study will identify novel mechanisms that can enhance the antitumor efficacy of FASN inhibitors and provide the necessary preclinical data for the development of a new combination treatment strategy to improve patient outcome.

PI_NAMEs: EVERS, BERNARD MARK;GAO, TIANYAN  (contact)

PROGRAM_OFFICER_NAME: CHEN, WEIWEI

PROJECT_TERMS: Acetyl Coenzyme A;anti-cancer;antitumor effect;Attenuated;Automobile Driving;Binding;Biological Models;cancer cell;Cancer Etiology;Cancer Patient;cancer therapy;Cell Death Induction;Cessation of life;Chemoresistance;chemotherapeutic agent;chemotherapy;clinical investigation;Clinical Trials;clinically relevant;Colon;colon cancer patients;colon cancer treatment;Colon Carcinoma;Colorectal Cancer;colorectal cancer treatment;Combined Modality Therapy;Cytoplasm;Data;Development;digital;Disease Progression;DNA Damage;DNA Repair Pathway;Double-Blind Method;Drug resistance;Enzymes;Epigenetic Process;epigenetic regulation;fatty acid biosynthesis;fatty acid metabolism;Fatty Acids;Fatty-acid synthase;glucose metabolism;Goals;Histone Acetylation;immune activation;Immune checkpoint inhibitor;Immune signaling;improved;In Vitro;in vivo;inhibitor;innovation;Interferon Type I;Investigation;irinotecan;lipid biosynthesis;lipid metabolism;Malignant Neoplasms;Malonyl Coenzyme A;Mediating;Membrane Lipids;membrane synthesis;Metabolic Control;Metabolism;Modeling;Molecular;Molecular Target;multidisciplinary;novel;Nucleosomes;Oncogenic;Oral;Pathway interactions;patient derived xenograft model;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;Placebo Control;placebo group;pre-clinical;preclinical study;prevent;Proliferating;Protein Acetylation;Publishing;Randomized;recruit;Regulation;Resectable;response;Role;Safety;Signal Pathway;Signal Transduction;Site;small molecule inhibitor;Specimen;Stimulator of Interferon Genes;stressor;T-Lymphocyte;Technology;Testing;Therapeutic;therapy resistant;treatment strategy;tumor;tumor growth;tumor metabolism;tumor progression;tumor xenograft;tumor-immune system interactions;tumorigenesis;uptake

PROJECT_TITLE: Fatty Acid Synthase as a Novel Molecular Target for Colon Cancer Treatment

STUDY_SECTION: MCTC

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics C Study Section [MCTC]


NIH_SPENDING_CATS: Aging;Neurodegenerative;Neurosciences

ORG_CITY: COLD SPRING HARBOR

ORG_NAME: COLD SPRING HARBOR LABORATORY

ORG_STATE: NY

PHR: Cold Spring Harbor Laboratory Conference on  Protein Homeostasis in Health and Disease  April 24 – 28, 2024 PROJECT NARRATIVE Proteins are composed of polymers of amino acids (or polypeptides) and execute essential tasks in all living organisms. Protein function is critically dependent on the folding of their constituent polypeptides into active three-dimensional structures through the interactions of molecular chaperones. Protein homeostasis is achieved by balanced synthesis, folding, translocation and degradation of proteins. Experimental evidence accumulated in the recent past has revealed that failure of protein homeostasis in aging leads to some of the most devastating diseases affecting humanity. The latter include common neurodegenerative disorders, such as Parkinson’s Disease and Alzheimer’s Disease, common metabolic disorders such as Diabetes and a host of other age- related conditions. The Cold Spring Harbor Meeting on Protein Homeostasis in Health and Disease brings together experts in diverse aspects of protein folding, the cellular response to protein misfolding and diseases and therapeutic approaches for age-associated diseases of protein homeostasis. As such it serves as the premier clearinghouse for ideas on how to eventually translate the basic discoveries in the area to future treatments of recalcitrant diseases.

PI_NAMEs: STEWART, DAVID J. (contact)

PROGRAM_OFFICER_NAME: OROSZ, ANDRAS

PROJECT_TERMS: Affect;age related;age-related disease;Aging;aging process;aging related disease;Alzheimer's Disease;Amino Acids;Amyloidosis;Area;arm;Attention;Autophagocytosis;Basic Science;Binding;Biochemical;Biogenesis;biological adaptation to stress;Biological Process;Biology;Biomedical Research;Biophysics;Businesses;cardiac aging;career;Cell Aging;Cell Compartmentation;Cell Physiology;cell type;Cells;Cellular Stress;Client;Communicable Diseases;Complement;Complex;Data;Degenerative Disorder;Development;Diabetes Mellitus;Discipline;Disease;Ensure;Environment;Equilibrium;Explosion;Faculty;Feedback;Financial Support;Fostering;Future;Gender;General Population;Goals;graduate student;Health;healthy aging;Heart;Heart Diseases;Heat shock proteins;Heat-Shock Response;Homeostasis;hormonal signals;Humanities;Huntington Disease;Impairment;In Vitro;in vivo;Industry;insight;Institution;interest;International;Knowledge;Laboratories;lectures;Lightning;macromolecular assembly;Malignant Neoplasms;Measures;Medicine;meetings;Metabolic Diseases;Metabolism;Methods;model organism;Molecular Chaperones;multicatalytic endopeptidase complex;Nerve Degeneration;Neurodegenerative Disorders;novel therapeutic intervention;Oral;Organism;Parkinson Disease;Participant;Pathway interactions;Phase Transition;Physiology;Polymers;polypeptide;Postdoctoral Fellow;posters;Prion Diseases;Process;protein aggregation;Protein Biosynthesis;Protein Conformation;protein degradation;protein folding;protein function;protein misfolding;Proteins;proteostasis;proteostasis loss;Quality Control;Questionnaires;Recording of previous events;Rejuvenation;repaired;Research Institute;Research Personnel;response;Ribosomes;Risk;Role;Schedule;Science;Scientist;Signal Transduction;skills;Slide;Stress;stress granule;success;symposium;System;Therapeutic;Thinking;three dimensional structure;Toxic effect;Translating;Ubiquitin;virtual;Work

PROJECT_TITLE: CSHL 2024 Protein Homeostasis in Health and Disease Conference

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development for Established Investigators and Conference Grants Study Section[AGCD-4]


ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

ORG_CITY: NEW YORK

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: COLUMBIA UNIV NEW YORK MORNINGSIDE

PHR: Project Narrative The Columbia Population Research Center (CPRC) will contribute to the public’s health by facilitating and supporting collaboration for researchers from across Columbia University who, because they are in different departments, schools, or disciplines, would not otherwise connect. Our activities will enhance affiliates’ research in five primary research areas – children, youth, and families; climate and environment; reproductive health and HIV/AIDS; immigration/migration; and urbanism and neighborhoods – with a cross-cutting focus on inequalities and policies, and a particular emphasis on promoting the development of junior scientists.

PI_NAMEs: HIRSCH, JENNIFER S;TEITLER, JULIEN O (contact)

PROJECT_TERMS: Address;Applications Grants;Area;Arts;Award;Budgets;Child;Cities;Climate;Collaborations;college;Communities;Data;Data Science;Development;Direct Costs;Discipline;Discipline of obstetrics;Economics;Educational workshop;Ensure;Environment;Environmental Health;environmental justice;experience;Faculty;Family;Fostering;Funding;Grant;Gynecology;health inequalities;HIV/AIDS;Immigration;Inequality;Infrastructure;innovation;Institution;Investments;Mentors;Methods;migration;Mission;National Institute of Child Health and Human Development;National Institute of Environmental Health Sciences;Neighborhoods;New York;Peer Review;Personal Satisfaction;Policies;Population;Population Dynamics;Population Research;Productivity;programs;Public Health;Publications;Reproductive Health;Request for Applications;Research;Research Infrastructure;Research Personnel;Resources;Role;School Nursing;Schools;Science;Scientist;Secure;Senior Scientist;Series;Social Policies;Social Work;Speed;Structure;success;symposium;teacher;Time;Training;Universities;Vulnerable Populations;Work;working group;Youth

PROJECT_TITLE: Columbia Population Research Center


PI_NAMEs: WALDFOGEL, JANE  (contact)

PROJECT_TERMS: Address;Applications Grants;Area;Award;Budgets;Cities;Collaborations;Communication;Communities;Data;data access;Data Storage and Retrieval;Databases;Decentralization;Dedications;Development;Development Plans;Educational workshop;Ensure;Evaluation;Event;Faculty;Faculty Recruitment;Funding;Geography;Goals;Grant;Health Services Accessibility;Infrastructure;innovation;Institution;Institutional Review Boards;Knowledge;Leadership;member;Mentors;Methods;Mission;Monitor;New York;Pathway interactions;Performance;Population;Population Dynamics;Population Research;Population Sciences;Problem Solving;programs;Protocols documentation;Research;Research Assistant;Resources;Schools;Scientist;Secure;Services;Shoulder;Strategic Planning;Stream;success;Time;Training;Universities;Variant;Work;working group

PROJECT_TITLE: Columbia Population Research Center - Administrative Core


PI_NAMEs: NEIDELL, MATTHEW J (contact)

PROJECT_TERMS: Address;Advisory Committees;Annual Reports;Area;Articulation;Arts;Award;Cities;Collaborations;Collection;Communities;Creativeness;Demographer;design;Development;Discipline;Educational workshop;Ensure;Event;Faculty;Fostering;Funding;Glean;Goals;Grant;Growth;health management;Health Policy;Heart;Home;Inequality;innovation;insight;Interdisciplinary Study;Joints;K-Series Research Career Programs;Leadership;Location;member;Mentors;Mission;Monitor;New York;New York City;Outcome;Peer Review;Policies;Population;Population Dynamics;Population Research;Process;Productivity;programs;Public Health Schools;Qualifying;Research;Research Assistant;Research Personnel;Research Project Grants;Resource Sharing;Resources;Scholars Program;Schools;Science;Scientist;Series;Services;Social Work;Sociology;symposium;synergism;Universities;visiting scholar;Work;working group

PROJECT_TITLE: Columbia Population Research Center - Development Core


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Data Science;Networking and Information Technology R&D (NITRD);Social Determinants of Health

PI_NAMEs: TEITLER, JULIEN O (contact)

PROJECT_TERMS: Applications Grants;Artificial Intelligence;Arts;astrophysics;Censuses;cluster computing;Collaborations;Communities;computer infrastructure;Computer software;Computer Systems;Consultations;Data;data access;data acquisition;Data Analyses;data centers;Data Collection;data enclave;Data Science;Data Set;data sharing;data visualization;Development;Economics;Educational workshop;Elements;Environment;experience;Faculty;Family;field study;field survey;Fostering;Funding;Future;Generations;Geography;High Performance Computing;human subject;Information Technology;Infrastructure;innovation;Institution;interest;Interview;Joints;Leadership;Licensing;Longitudinal Surveys;Maps;Medicaid;Memory;Methodology;Methods;New York City;Personal Satisfaction;Phase;Policies;Population Dynamics;population health;Population Research;Poverty;Preparation;Price;Privacy;Probability Samples;Process;Production;Productivity;Protocols documentation;Public Health;Qualifying;Reporting;Research;Research Design;Research Methodology;Research Support;Resources;scale up;Scholarship;Schools;Science;Scientist;Secure;Services;social;social science research;Social Sciences;Social Work;statistics;Surveys;symposium;System;Technical Expertise;Technology;tool;Training;United States National Institutes of Health;Universities;virtual;Work

PROJECT_TITLE: Columbia Population Research Center - Computing and Methods Core


ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Immunization;Infectious Diseases;Lung;Prevention;Rare Diseases;Tuberculosis;Tuberculosis Vaccine;Vaccine Related

ORG_CITY: SEATTLE

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE Our lack of understanding of the mechanisms of T cell mediated protection against Tuberculosis, a disease responsible for 1.6 million deaths in 2021, has hampered our ability to develop new vaccine strategies. Antigen- independent T cell activation, termed bystander activation, has shown protective effects in response to M.tb infection but has not been fully explored or characterized. Here, we will comprehensively analyze the role of bystander activation in two T cell subsets in the context of M.tb infection to extensively explore this protective pathway as a possible vaccine target.

PI_NAMEs: WINTER, CASSANDRA  (contact)

PROGRAM_OFFICER_NAME: MENDEZ, SUSANA

PROJECT_TERMS: Adult;Anti-Bacterial Agents;Antigen Presentation;Antigens;antimicrobial;Bacteria;Bacterial Infections;BCG Vaccine;Categories;Cause of Death;CD4 Positive T Lymphocytes;CD8B1 gene;cell type;Cells;Cessation of life;Child;Clinical;Coculture Techniques;comparison control;Cues;cytokine;Cytokine Receptors;Cytokine Signaling;Cytotoxic T-Lymphocytes;Disease;Engineering;Exhibits;Future;glucose mycolate;Granuloma;Helper-Inducer T-Lymphocyte;Histocompatibility;Human;humanized mouse;Immune;Immune response;Immunity;improved;Infant;Infection;Infectious Agent;Inflammatory;intraepithelial;Knowledge;Licensing;Lipids;Lung Diseases;Malignant Neoplasms;Mediating;Membrane Proteins;Memory;Methods;Modeling;mouse model;mycobacterial;Mycobacterium tuberculosis;Mycolic Acid;novel;novel vaccines;Organoids;Pathway interactions;Peptides;Phenotype;Play;Predisposition;programs;protective effect;protective pathway;Proteins;Publishing;receptor;Research;response;Role;Sampling;Signal Transduction;Signaling Protein;Small Interfering RNA;Structure;System;T memory cell;T-Cell Activation;T-Cell Receptor;T-Independent Antigens;T-Lymphocyte;T-Lymphocyte Subsets;Tonsil;Tuberculosis;tuberculosis granuloma;tuberculosis immunity;Tuberculosis Vaccines;vaccine access;vaccine strategy;vaccine trial;Vaccines

PROJECT_TITLE: The role of antigen-independent T cell activation in controlling M. tuberculosis infection

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F07A-B (20)]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Diabetes;Infectious Diseases;Wound Healing and Care

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Group B Streptococcus (GBS) is mainly associated with neonatal meningitis but is also the third leading cause of death from skin and subcutaneous infection. In fact, GBS is increasingly associated with diabetes as a common colonizer of diabetic wounds, but little is known about GBS factors that allow colonization and persistence in the highly inflammatory wound environment. This proposal seeks to understand how GBS metal homeostasis and methylglyoxal detoxification contributes to GBS survival during diabetic wound infection.

PI_NAMEs: AKBARI, MADELINE SOHAYLA (contact)

PROGRAM_OFFICER_NAME: GU, XIN-XING

PROJECT_TERMS: Address;Adult;Advanced Glycosylation End Products;ATP-Binding Cassette Transporters;Bacteria;Bacterial Infections;Binding;Biological Assay;Biophysics;Calorimetry;Cause of Death;chronic wound;cofactor;Complications of Diabetes Mellitus;Coupled;Data;Data Set;Diabetes Mellitus;diabetic;Diabetic mouse;diabetic ulcer;Diffusion;Divalent Cations;Drug Metabolic Detoxication;Enzymes;Escherichia coli;female reproductive tract;gastrointestinal;Genetic Transcription;Glucose;Glycolysis;Growth;healing;Health;HL-60 Cells;Homeostasis;Human;immune function;Immune response;In Vitro;in vivo Model;Individual;Infection;Infectious Skin Diseases;Inflammation;Inflammatory;Invaded;Lactoylglutathione Lyase;Leukocyte L1 Antigen Complex;Manganese;Measures;Mediating;Metabolism;metal chelator;Metals;Minimum Inhibitory Concentration measurement;Modeling;Monitor;Mus;Neonatal meningitis;neonate;Neuropathy;neutrophil;Nickel;novel;Nutrient;Nutritional Immunity;optical emission spectroscopy;Organism;Outcome;pathobiont;pathogen;Pathogenesis;Pathway interactions;Peroxidases;Persons;Plasma;Population;Predisposition;Process;Production;Proteins;Pyruvaldehyde;response;Role;S100A9 gene;Serum;Skin;Soft Tissue Infections;Specificity;Streptococcal Infections;Streptococcus Group B;Streptozocin;Stress;Structure;subcutaneous;System;Therapeutic;Titrations;Toxin;transcriptome sequencing;Vascular Diseases;Whole Blood;Work;wound;wound environment;Wound Infection;Wound models;Zinc

PROJECT_TITLE: Host-pathogen interactions during GBS diabetic wound infections


NIH_SPENDING_CATS: Cancer;Immunotherapy;Radiation Oncology

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE - ADMINISTRATIVE CORE The Project Narrative is not required for the Administrative Core as per the PAR-18-290 Funding Opportunity  Announcement.

PI_NAMEs: MORRIS, ZACHARY SCOTT;WEICHERT, JAMEY P (contact)

PROGRAM_OFFICER_NAME: CAPALA, JACEK

PROJECT_TERMS: Adherence;Administrative Coordination;Advisory Committees;animal care;Award;Cancer Center;Chemicals;Communication;Communication Programs;Complex;Development;Doctor of Philosophy;Ensure;Expenditure;experience;Fostering;Funding;Funding Opportunities;Future;Goals;Grant;Guidelines;Hygiene;immunoregulation;Immunotherapy;Institution;Laws;Leadership;meetings;Mission;Molecular Target;Monitor;National Cancer Institute;organizational structure;Policies;Principal Investigator;programs;Radiation;Radionuclide therapy;Regulation;Reporting;Research;Research Personnel;Research Project Grants;Research Support;Resources;response;Safety;Services;Structure;Time;timeline;tumor;Universities;Vertebral column;web site;Wisconsin


NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Clinical Research;Neurosciences;Physical Injury - Accidents and Adverse Effects;Physical Rehabilitation;Prevention;Rehabilitation

ORG_DEPT: PHYSICAL MEDICINE & REHAB

PHR: PROJECT NARRATIVE Individuals with transfemoral amputation fall significantly more often than the general population, and when fitted with a traditional prosthetic limb, nearly one-third of people experience severe complications with their prosthetic socket. Today, a secondary procedure called osseointegration is offered to address socket-related issues with a direct bone-anchored prosthesis implant, which offers a novel potential benefit to balance through improved sensation and body control. Understanding the effects of an osseointegrated prosthesis on sensation and postural control will help to identify specific functional movement deficiencies to target during therapy and rehabilitation to decrease fall risk.

PI_NAMEs: TRACY, JAMES B (contact)

PROGRAM_OFFICER_NAME: NURMINSKAYA, MARIA

PROJECT_TERMS: Address;Amputation;Area;Artificial Implants;body position;bone;bone prosthesis;career;Clinical;clinical care;Clinical Skills;Competence;design;Development;Equilibrium;Esthesia;experience;Eye;Fall prevention;fall risk;falls;fear of falling;Femur;foot;Frequencies;Gait;gait examination;General Population;Health;high risk;Implant;improved;improved mobility;Individual;Intervention;Joints;Knee;Knowledge;Learning;Length;Life;limb loss;Limb Prosthesis;Limb structure;Measures;Mechanical Stimulation;Medial;Movement;Muscle;Musculoskeletal Equilibrium;neurophysiology;novel;osseointegrated implant;Osseointegration;Outcome;Pathway interactions;Patients;Persons;Phase;Physical activity;Population;Populations at Risk;Positioning Attribute;Postural adjustments;Preparation;pressure;Procedures;Proprioception;Prosthesis;prosthesis fitting;prosthetic socket;Reaction Time;Recovery;Rehabilitation therapy;Reproduction;Research;residual limb;satisfaction;Self Efficacy;Shapes;skin irritation;Statistical Data Interpretation;Testing;Time;tool;Training;treadmill;United States;vibration;Walking;Width

PROJECT_TITLE: Osseoperception, Proprioception, and Postural Control in Individuals with an Osseointegrated Prosthesis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F10B-Q (20)]


ADMINISTERING_IC: FD

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: AMES

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: IOWA STATE UNIVERSITY

ORG_STATE: IA

PHR: PROJECT NARRATIVE In contrast to major food-producing species such as cattle and swine, for which many antimicrobials are labeled for treatment of respiratory disease, there is currently only a single antibiotic (ceftiofur) approved by the FDA for treatment of respiratory disease in goats. Ceftiofur sodium requires daily administration which may decrease efficacy in situations where owner compliance with labeled instructions is lacking. Therefore, there is an urgent need for additional FDA-approved products for treatment of respiratory disease in goats.

PI_NAMEs: GORDEN, PATRICK J (contact)

PROGRAM_OFFICER_NAME: MARESCA, JANAH

PROJECT_TITLE: Analytical method validation to detect and quantify tulathromycin residues in caprine liver

STUDY_SECTION_NAME: Special Emphasis Panel[ZFD1 CVM-J (01)]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Immunization;Immunotherapy;Lung;Orphan Drug;Pulmonary Fibrosis;Rare Diseases

ORG_CITY: Seattle

ORG_NAME: VIRTICI, LLC

PHR: Project Narrative Idiopathic Pulmonary Fibrosis (IPF) is a chronic pulmonary disease characterized by vascular injury and progressive fibrosis of the lungs. This project aims to develop a bispecific antibody, VTC-890, for the treatment of IPF. Since present therapies for IPF fail to prevent death or improve quality of life for patients, successful commercialization of VTC-890 would ultimately provide profound relief for an incurable, fatal disease.

PI_NAMEs: FANGER, NEIL A (contact)

PROGRAM_OFFICER_NAME: VUGA, LOUIS J

PROJECT_TERMS: Address;Affinity;Animal Model;Animals;Anti-Inflammatory Agents;Antibodies;Antibody Affinity;Antibody Therapy;Asthma;Autoimmune Diseases;Automobile Driving;Binding;Biological Assay;Bispecific Antibodies;Blocking Antibodies;Blood;cell bank;Cell Line;cell type;Cells;Cessation of life;Characteristics;chemokine;Chronic;Chronic lung disease;Clinic;Clinical;Clinical Research;commercialization;Complex;Crohn's disease;cytokine;Data Set;design;Development;Disease;Disease Progression;Dose;Environmental Exposure;Family;Fibroblasts;Fibrosis;fibrotic lung;fibrotic lung disease;first-in-human;Formulation;Genetic;Goals;herpesvirus entry mediator;Hyperplasia;idiopathic pulmonary fibrosis;immune cell infiltrate;immunogenicity;Immunoglobulin G;improved;Inflammatory;inhibitor therapy;Injections;Laboratories;Lead;lead candidate;Libraries;Light;LIGHT protein;Lung;lymphotoxin beta receptor;Macaca fascicularis;Mammalian Cell;manufacture;Measures;Medical;Minor;Modeling;Mus;Mutagenesis;Mutagens;novel;Pathology;Pathway interactions;Patients;Phage Display;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;Phase;Phase I Clinical Trials;Play;Positioning Attribute;pre-clinical;pre-Investigational New Drug meeting;prevent;Process;Production;Profibrotic signal;Publishing;Pulmonary Fibrosis;pulmonary function decline;Pulmonary Inflammation;Quality of life;receptor;receptor binding;Recombinants;Recommendation;Reporting;Research;Research Design;respiratory;Rheumatoid Arthritis;Role;side effect;Site;Small Business Innovation Research Grant;Structure of parenchyma of lung;Symptoms;System;Systemic Scleroderma;Testing;Therapeutic;Tissues;TNF gene;TNFSF15 gene;Toxicology;Ulcerative Colitis;vascular injury;vector

PROJECT_TITLE: A Novel Bispecific Antibody for the Treatment of Idiopathic Pulmonary Fibrosis


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: BALTIMORE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: Most individuals with opioid use disorder (OUD) do not receive treatment due to persistent, complex and nuanced barriers to OUD care; and OUD commonly co-occurs with depression (dually diagnosed population) further complicating treatment pathways. Using both publicly-available and Medicaid claims data, the goal of this study is to develop a composite index that quantifies the potential to access resources for OUD treatment, examine longitudinal treatment utilization patterns of dually diagnosed individuals to determine the optimal trajectories of depression-OUD treatment combinations, and use the index to contextualize each treatment utilization trajectory. This research addresses an understudied population of those with dual diagnosis and in the long term, will contribute to generating a whole-person view towards the treatment and health outcomes for people with OUD and those dually diagnosed with depression.

PI_NAMEs: SAINI, JANNAT  (contact)

PROGRAM_OFFICER_NAME: GAINES, CHRISTOPHER M

PROJECT_TITLE: Towards a Better Understanding of Access Factors Associated with Treatment and Outcomes among Medicaid Enrollees with Opioid Use Disorder and Depression

STUDY_SECTION: HCRT

STUDY_SECTION_NAME: Healthcare Research Training [HCRT]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Cervical Cancer;Genetics;Human Genome;Infectious Diseases;Prevention;Sexually Transmitted Infections;Women's Health Research

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: Project Narrative Despite the high prevalence of HPV infections which are the cause of 5% of all human cancers, prevention of HPV-associated malignancies is limited by a lack of antivirals suitable for HPV-infected individuals. In order to address this significant public health burden, we selected ERBB2 as a candidate target for the prevention of HPV-driven pathologies based on high level single cell sequencing approaches and publicly available data on HPV-associated cancer types. Herein we aim to define mechanisms of ERBB2 regulation by HPV, and the contribution of ERBB2 signaling to HPV-driven pathologies, with the goal of targeting ERBB2 via re-purposing FDA-approved drugs for antiviral cancer prevention and perhaps treatment.

PI_NAMEs: RIVERA-CRUZ, COSETTE M (contact)

PROGRAM_OFFICER_NAME: ODEH, HANA M

PROJECT_TERMS: 3-Dimensional;Address;Anti-viral Agents;antiviral drug development;Atlases;Biological;Biological Markers;cancer prevention;cancer therapy;cancer type;carcinogenesis;Cell Compartmentation;Cell Physiology;Cell Proliferation;Cells;Cervical Intraepithelial Neoplasia;Cervical Squamous Cell Carcinoma;chronic infection;Clinical;clinically relevant;Data;Development;Dimerization;EGFR gene;ELF3 gene;Episome;Epithelial Cells;Epithelium;erbB-2 Receptor;ERBB2 gene;ERBB3 gene;experimental study;FDA approved;Fibroblasts;Genetic;genetic signature;Genome;Goals;Head and Neck Squamous Cell Carcinoma;High Prevalence;high risk;HPV analysis;HPV positive;Human;Human papilloma virus infection;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;Human papillomavirus 16;In Vitro;in vivo;Individual;Infection;inhibitor;keratinocyte;Knowledge;Laboratories;Life Cycle Stages;Literature;Maintenance;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Neoplasms;MAP Kinase Gene;migration;Molecular;Mucous Membrane;Mutation;Neoplastic Cell Transformation;novel;novel strategies;Oncogenic;Oncoproteins;Ontology;Oropharyngeal Squamous Cell Carcinoma;Outcome;overexpression;Papillomavirus Transforming Protein E6;Pathogenesis;pathogenic virus;Pathologic;Pathology;Patient-Focused Outcomes;Pharmaceutical Preparations;Phenotype;Phosphorylation;PI3K/AKT;Play;Population;preclinical study;premalignant;Prevention;programs;Public Health;receptor;Receptor Protein-Tyrosine Kinases;Regulation;Reporting;Resolution;Risk Factors;Role;Sexually Transmitted Diseases;side effect;Signal Transduction;single cell sequencing;single-cell RNA sequencing;Skin;Squamous cell carcinoma;Squamous Epithelium;Stratified Epithelium;Stratified Squamous Epithelium;Surface;System;Systemic Therapy;Testing;The Cancer Genome Atlas;three-dimensional modeling;Tissues;tool;transcriptome;treatment strategy;United States;Up-Regulation;Vaccines;Viral;viral carcinogenesis;Viral Genes;Viral Genome;Virus;Virus Assembly;virus host interaction;women's outcomes;Work

PROJECT_TITLE: The role of ERBB2 signaling in HPV-induced pathologies

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F07C-Y (20)]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

ORG_CITY: CAMBRIDGE

ORG_NAME: HARVARD UNIVERSITY

PHR: PROJECT NARRATIVE: Overall The Harvard University CFAR (HU CFAR) provides the infrastructure to coordinate, support and add value to Harvard investigators’ cutting-edge multidisciplinary HIV research programs and to forge new collaborations and synergies. The HU CFAR pursues innovative initiatives to address critical HIV-related research priorities and train the next generation of HIV researchers. By leveraging the exceptional strengths of Harvard and its institutional support, the HU CFAR promises to continue to provide major leadership in the global effort to prevent and treat HIV.

PI_NAMEs: GANDHI, RAJESH T (contact)

PROGRAM_OFFICER_NAME: REFSLAND, ERIC WILLIAM

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Area;Award;base;Basic Science;Behavioral Sciences;biobehavior;Bioinformatics;Biometry;Boston;career;catalyst;Clinical;Clinical Sciences;co-infection;Collaborations;community collaboration;community engaged research;community organizations;community partners;community science;comorbidity;Dana-Farber Cancer Institute;Development;Disease;Ensure;Epidemic;equity, diversity, and inclusion;forging;Funding;General Hospitals;Generations;Goals;Grant;Health;HIV;HIV therapy;Hospitals;improved;Incidence;Infection;Infrastructure;innovation;Institution;Interdisciplinary Study;International;Investments;Israel;laboratory equipment;Leadership;Malignant Neoplasms;Massachusetts;Medical center;medical schools;Medicine;member;Mentors;Mentorship;Mission;multidisciplinary;next generation;Pediatric Hospitals;Persons;Pilot Projects;Play;Population;prevent;Prevention;Process;programs;Public Health;Public Health Schools;Recommendation;recruit;Research;Research Personnel;Research Priority;Research Training;Role;Schools;Services;Site;Strategic Planning;Sum;synergism;Translational Research;United States National Institutes of Health;Universities;Woman;working group

PROJECT_TITLE: Harvard University Center for AIDS Research

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 KSW-A (J1)]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Dental, Oral, and Craniofacial Disease;Drug Abuse (NIDA only);HIV/AIDS;Immunization;Infectious Diseases;Prevention;Substance Misuse;Vaccine Related;Vaccine Related - AIDS

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Area;Award;Basic Science;Boston;career;Communication;Communities;community engagement;community organizations;Dana-Farber Cancer Institute;Development;Educational workshop;Ensure;Epidemic;equity, diversity, and inclusion;Faculty;Funding Opportunities;Future;General Hospitals;Geography;Goals;Health;health organization;HIV;Hospitals;innovation;Institution;Interdisciplinary Study;International;Israel;Leadership;Massachusetts;Medical center;medical schools;Medicine;member;Mentors;multidisciplinary;next generation;operation;Pediatric Hospitals;Play;Policies;prevent;Procedures;Process;programs;Public Health;Public Health Schools;Recommendation;Research;Research Personnel;Resources;Role;Services;Site;Strategic Planning;Structure;symposium;Training;Training and Education;Transcend;Translational Research;Universities;Woman;Work;working group

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Clinical Research;Dental, Oral, and Craniofacial Disease;Drug Abuse (NIDA only);HIV/AIDS;Immunization;Infectious Diseases;Prevention;Substance Misuse;Vaccine Related;Vaccine Related - AIDS

PI_NAMEs: TSIBRIS, ATHE M. (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Applications Grants;Area;Award;Basic Science;biobehavior;career;career development;clinical epidemiology;Collaborations;Communities;community science;Computational Biology;Development;Disease;Education;Educational workshop;Ensure;equity, diversity, and inclusion;Evolution;Faculty;Feedback;flexibility;Fostering;Foundations;Funding;Funding Mechanisms;Funding Opportunities;Generations;Goals;Grant;health economics;HIV;HIV/AIDS;Hospitals;Incentives;Individual;Institution;International;Investments;leadership development;medical schools;Medicine;meetings;member;Mentors;Mentorship;microbial genomics;Mission;Modeling;Mollies;multidisciplinary;next generation;Outcome;outreach;Pathogenesis;Process;Program Reviews;programs;Public Health Schools;Publications;Request for Proposals;Research;Research Activity;Research Personnel;Research Priority;Resources;Science;Scientist;Site;skills;South Africa;Strategic Planning;Structure;Technology;Training;training opportunity;Translational Research;Uganda;Underrepresented Minority;United States National Institutes of Health;Universities;Virginia;Woman;working group;Writing

PROJECT_TITLE: Developmental and Mentoring Core


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Bioengineering;Biotechnology;Cancer;Cancer Genomics;Dental, Oral, and Craniofacial Disease;Drug Abuse (NIDA only);Genetics;HIV/AIDS;Human Genome;Immunization;Infectious Diseases;Networking and Information Technology R&D (NITRD);Prevention;Substance Misuse;Vaccine Related;Vaccine Related - AIDS

PI_NAMEs: LINGWOOD, DANIEL  (contact)

PROJECT_TERMS: 2019-nCoV;Acceleration;Acquired Immunodeficiency Syndrome;AIDS prevention;Area;Basic Science;Biocompatible Materials;Bioinformatics;Biometry;bisulfite sequencing;Boston;career;Cell Culture Techniques;Cell Separation;Cells;ChIP-seq;Clinical Sciences;Clustered Regularly Interspaced Short Palindromic Repeats;co-infection;Collaborations;Color;Communities;comorbidity;Computer software;Computing Methodologies;Confocal Microscopy;Containment;Contracts;Dana-Farber Cancer Institute;data exchange;data integration;Data Set;data sharing;Development;Disease;Doctor of Philosophy;Emerging Technologies;Epidemic;Epigenetic Process;Evaluation;Evolution;Flow Cytometry;Fluorescence;Fostering;Funding;General Hospitals;genome wide methylation;Genomics;Geographic Distribution;Goals;Grant;Health;HIV;HIV Infections;HIV/TB;Hospitals;Human;Image;Image Analysis;Imaging technology;Immunologic Surveillance;Immunology;indexing;Individual;Infrastructure;Institution;instrumentation;International;Israel;Laboratories;Machine Learning;Massachusetts;Medical;Medical center;medical schools;member;Mentors;Microscopy;Mission;Molecular;Molecular Biology;Monkeypox;Mutation;neutralizing antibody;new technology;online community;Pattern;Pediatric Hospitals;peripheral blood;Phenotype;Procedures;Protocols documentation;Public Health Schools;Recommendation;Research;Research Design;Research Personnel;Sampling;Scanning;Science;Services;single cell genomics;Site;Slide;Sorting;Specimen;Standardization;Structure;superresolution microscopy;symposium;synergism;Targeted Resequencing;Techniques;Technology;theories;therapeutic development;therapy development;Time;Tissue imaging;Tissues;tool;Training;training opportunity;transcriptome sequencing;transcriptomics;ultra high resolution;United States National Institutes of Health;Universities;Vaccine Design;vaccine development;Viral;virus host interaction;Woman

PROJECT_TITLE: Advanced Lab Technologies Core


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Dental, Oral, and Craniofacial Disease;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunization;Infectious Diseases;Prevention;Substance Misuse;Vaccine Related;Vaccine Related - AIDS

PI_NAMEs: LI, JONATHAN  (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Acute;adaptive immune response;Affect;Aftercare;AIDS prevention;Award;Basic Science;Behavioral;bench to bedside;Boston;career;Cells;Characteristics;Chronic;Clinical;clinical care;clinical infrastructure;Clinical Research;Clinical Sciences;Clinical Trials;co-infection;cohort;Collaborations;Communication;Communities;comorbidity;Data;Databases;design;Development;Education;Education and Outreach;Enrollment;Epidemic;Fostering;Funding;Goals;HIV;HIV Infections;HIV therapy;HIV/AIDS;Human;Immunity;Infrastructure;Innate Immune Response;innovation;insight;International;Investigation;Journals;Link;Mediator;Medicine;member;Mentorship;Mission;multidisciplinary;Nature;New England;new technology;next generation;novel;novel therapeutics;online resource;outreach program;Participant;Persons;Population;pre-exposure prophylaxis;Process;programs;Prospective Studies;Publications;Recording of previous events;Research;Research Personnel;research study;Resources;response;Risk;Sampling;Science;Scientist;Seminal;Series;Services;Site;social;Specimen;STEM research;Strategic Planning;Time;Translational Research;Underserved Population;United States National Institutes of Health;Universities

PROJECT_TITLE: Clinical Core


PI_NAMEs: PARKER, ROBERT A. (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Africa South of the Sahara;Animals;Applications Grants;Area;Award;base;Behavioral;Bioinformatics;Biometry;Biostatistics Core;Budgets;career;Clinical;Clinical Trials;cohort;Collaborations;Communities;Consultations;Country;COVID-19 pandemic;Data;Data Analyses;data management;data sharing;database design;Databases;design;Development;Doctor of Philosophy;Education;Exclusion;Funding;Future;Goals;Grant;Grant Review;HIV;implementation study;Individual;International;K-Series Research Career Programs;Laboratories;lectures;Link;Manuscripts;Medicine;meetings;member;Mentors;Mentorship;Methods;Mission;Outcome Study;Prevention;Program Appropriateness;programs;Reporting;Research;Research Design;Research Personnel;research study;Services;Source;Surveys;symposium;Training;Training Programs;United States National Institutes of Health;Universities;virtual;Work

PROJECT_TITLE: Biostatistics and Bioinformatics Core


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Dental, Oral, and Craniofacial Disease;Dissemination and Implementation Research;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunization;Infectious Diseases;Mental Health;Prevention;Social Determinants of Health;Substance Misuse;Vaccine Related;Vaccine Related - AIDS

PI_NAMEs: MAYER, KENNETH H (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Adolescence;Affect;Africa;Aging;AIDS prevention;antiretroviral therapy;Applications Grants;Award;Awareness;Behavior;Behavioral;behavioral and social science;biobehavior;Biomedical Research;Boston;Botswana;career;career development;Caring;Cities;Collaborations;Communities;community based participatory research;community based research;community collaboration;community engagement;community science;comorbidity;Consultations;Dedications;Development;Discipline;Doctor of Philosophy;Education;Epidemic;epidemic response;Ethnic Origin;Faculty;Feedback;Fostering;Funding;Gender;Goals;Grant;HIV;Human;Human immunodeficiency virus test;Immigrant;implementation outcomes;implementation science;Incidence;Individual;interest;Intervention;Leadership;London;Male Circumcision;medication compliance;Medicine;member;Mental Health;Mentors;Mentorship;Methodology;Migrant;Mission;Names;optimism;Play;Population;Poverty;pre-exposure prophylaxis;Prevention;Prevention Research;Process;programs;Qualitative Methods;Qualitative Research;Race;Reproductive Health;Research;Research Design;Research Methodology;Research Personnel;research study;Resources;Risk;Role;San Francisco;Series;Services;sex;Sexual and Gender Minorities;Site;social;social factors;Social Sciences;structural determinants;substance use;substance user;Testing;therapy development;tool;Translational Research;transmission process;treatment research;underserved community;United States National Institutes of Health;Universities;vaccine development;Vertical Disease Transmission;Work;working group

PROJECT_TITLE: Bio-Behavioral and Community Science Core


PI_NAMEs: BARNABAS, RUANNE VANESSA (contact)

PROJECT_TERMS: Acceleration;Acquired Immunodeficiency Syndrome;Address;Applications Grants;Award;Basic Science;Biological;Boston;cancer care;cancer cell;Cancer Center;cancer clinical trial;cancer therapy;Carcinogens;career;Caring;Cause of Death;Clinical;Clinical Sciences;cohort;Communities;community engagement;community partners;Data;Data Collection;Databases;Development;Diagnosis;Director's Working Group;Disparity;equity, diversity, and inclusion;evidence base;experience;Exposure to;Fostering;Funding;Funding Opportunities;Goals;Guidelines;Health;HIV;HIV Infections;Human Papillomavirus;immune clearance;Impairment;improved;Incidence;Individual;Inferior;Infrastructure;Institution;International;Intervention;Knowledge;leadership development;Low income;Malignant Neoplasms;Mentors;Mentorship;Oncogenic Viruses;Oncology;Outcome;outreach;Patient Care;Patients;Persons;Population;Positioning Attribute;prevent;preventive intervention;Process;programs;Quality of Care;Research;Research Activity;Research Personnel;Research Project Grants;Resources;Risk;Scientist;Screening for cancer;Site;Specimen;Structure;symposium;Tobacco;Training;training opportunity;Translational Research;tumor immunology;tumorigenesis;United States National Institutes of Health;Universities;working group

PROJECT_TITLE: HIV and Malignancy Scientific Working Group


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Hematology;Human Genome;Orphan Drug;Precision Medicine;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because the identification of m6A modifications in pre- treatment CD138+ tumor cells that are associated with treatment outcomes of multiple myeloma (MM), the 2nd most common hematologic malignancy and generally incurable, will improve our understanding of early relapse and therapy response. This contribution will be significant because patients at higher risk of treatment failure could be treated with more aggressive strategies up front. Thus, the proposed research is relevant to the part of NIH's mission that pertains to developing fundamental knowledge that will help reduce the mortality of MM.

PI_NAMEs: CHIU, BRIAN C-H (contact);ZHANG, WEI

PROGRAM_OFFICER_NAME: MAAS, STEFAN

PROJECT_TERMS: Address;Antibodies;Autologous Stem Cell Transplantation;Biological;Biological Process;Bone Marrow;Cell Differentiation process;Cells;Chemicals;Chromosome abnormality;Clinic;Clinical;clinical application;Clinical Trials;Collecting Cell;Cytogenetics;design;detection sensitivity;Development;Diagnosis;DNA Methylation;Drug resistance;Enrollment;Epigenetic Process;Exhibits;Funding;Goals;Hematologic Neoplasms;high risk;histone modification;Human;immune modulating agents;improved;innovation;Knowledge;Label;Link;Location;Malignant Neoplasms;Mammals;Maps;Messenger RNA;Methods;Methylation;Mission;Modernization;Modification;Molecular;mortality;Multiple Myeloma;neoplastic cell;new technology;new therapeutic target;Newly Diagnosed;next generation sequencing;novel;novel marker;novel therapeutic intervention;Nucleotides;Observational Study;Oncogenic;Outcome;partial response;participant enrollment;Pathway interactions;patient stratification;Patients;personalized management;Phase II Clinical Trials;Physiological;Plasma Cells;Post-Transcriptional Regulation;predicting response;Prognosis;prognostic;Prognostic Factor;Proteasome Inhibitor;Proteins;Public Health;Reader;Regimen;Regulation;Relapse;Reporting;Research;Residual Neoplasm;Resolution;response;risk stratification;RNA;Role;Sampling;Severity of illness;Site;stem cell self renewal;survival prediction;survivorship;Techniques;Therapeutic Intervention;Time;Transcript;transcriptome;Treatment Failure;Treatment outcome;treatment response;treatment strategy;United States National Institutes of Health

PROJECT_TITLE: RNA m6A modifications and treatment response in multiple myeloma

STUDY_SECTION: CONC

STUDY_SECTION_NAME: Clinical Oncology Study Section[CONC]


ORG_CITY: BERKELEY

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: OVERALL CORE: PROJECT NARRATIVE The Berkeley Population Center’s mission is to create and disseminate high impact research findings about population processes that relate to the health and well-being of the residents of this country and beyond. This goal is accomplished through innovative methods, population-based data and tested analytic tools, and a collaborative community of interdisciplinary researchers who focus on demography, population health, and reproductive health.

PI_NAMEs: GOLDSTEIN, JOSHUA R. (contact)

PROJECT_TERMS: Address;analytical tool;Area;base;California;career;cohort;Collaborations;college;Communication;Communities;Consultations;cost effective;Country;Data;data harmonization;data infrastructure;Data Science;Demography;Development;Discipline;Economics;Educational workshop;Elements;Environment;Event;Exposure to;Faculty;Family Policy;Financial Support;Fostering;frontier;Funding;Goals;Grant;Group Meetings;Growth;Health;High Performance Computing;high reward;HIV;innovation;Institution;interdisciplinary collaboration;Interdisciplinary Study;Investments;Knowledge;Leadership;Logistics;meetings;Mentors;Mentorship;Methodology;Methods;Mission;National Institute of Child Health and Human Development;notch protein;novel;operation;Personal Satisfaction;Phase;Population;population based;Population Dynamics;population health;Population Process;Population Research;Population Sciences;Population Study;Positioning Attribute;programs;Public Health;Public Policy;rapid growth;Reproductive Health;Research;Research Activity;research and development;Research Infrastructure;Research Personnel;Research Project Grants;Resources;Scholars Program;Schools;Science;Scientist;Secure;Services;Social Sciences;Social Welfare;Societies;Sociology;Students;symposium;Testing;Time;Training;Translating;Universities;virtual;Work;Writing

PROJECT_TITLE: Berkeley Population Center


NIH_SPENDING_CATS: Behavioral and Social Science

PROJECT_TERMS: cloud based;Collaborations;college;Communication;Communities;Community Participation;Complex;computing resources;Creativeness;Data;data resource;Data Science;Development;Educational workshop;Ensure;Environment;Ethics;Event;Faculty;Floor;Fostering;frontier;Funding Agency;Funding Opportunities;Goals;Grant;improved;Infrastructure;Institutional Review Boards;Interdisciplinary Study;interest;Internet;Leadership;Logistics;meetings;member;Modernization;Newsletter;novel;operation;Organization administrative structures;Paper;Policy Maker;Population;Population Research;Population Sciences;Posture;Productivity;programs;Public Health Schools;recruit;Research;Research Personnel;Research Project Grants;Resources;Science;Security;Series;Services;social media;social science research;Social Sciences;Societies;Special Event;symposium;Time;Travel;Twitter;Update;web site;Work


NIH_SPENDING_CATS: Clinical Research

PI_NAMEs: MIGUEL, EDWARD ANDREW (contact)

PROJECT_TERMS: Applications Grants;Area;Attention;Caliber;California;career;Collaborations;collaborative environment;Communities;Data;Dedications;Development;Discipline;Educational workshop;Environment;Event;Faculty;Feedback;Fostering;Funding;Goals;Grant;high reward;high risk;improved;innovation;Institution;Investments;Mentors;Methods;Mission;National Institute of Child Health and Human Development;Outcome;Population;Population Dynamics;Population Research;Population Sciences;Process;programs;Research;Research Infrastructure;Research Personnel;Research Priority;Resources;Scholars Program;Scientist;Series;Services;success;symposium;Time;Training;Universities;Writing


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Machine Learning and Artificial Intelligence;Prevention;Prostate Cancer;Racial and Ethnic Minority Health Research;Social Determinants of Health;Urologic Diseases

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Project Narrative The overarching goal of this project is to uncover biological and sociological factors that contribute to poor outcomes for prostate cancer in African American men. To address this goal, we propose to leverage a large, national, population-based cohort study (RESPOND) comprised of 12,500 African American men with prostate cancer identified through nine SEER and NPCR U.S. cancer registries. Over the next five years, we will continue to enhance the RESPOND cohort through additional measurement of exposures and outcomes to facilitate translational research that addresses critical scientific questions and hypotheses that have been suggested to contribute to prostate cancer outcomes in African American men, those being access to health care (Aim 1), structural and social neighborhood drivers (Aim 2), modifiable lifestyle factors, co-morbidities and genetics (Aim 3), and histopathologic-based risk prediction (Aim 4).

PI_NAMEs: HAIMAN, CHRISTOPHER ALAN (contact)

PROGRAM_OFFICER_NAME: BURNETT, ANDREA NICOLE

PROJECT_TERMS: Address;Affect;African American;African ancestry;Algorithms;Area;Attitude;Baseline Surveys;Behavior;Behavioral;Biological;Biological Factors;Body mass index;California;cancer health disparity;cancer imaging;cancer survival;care systems;Caring;Chronic;Clinical Management;cohort;Cohort Studies;Communities;comorbidity;Complex;COVID-19 pandemic effects;Data;data dashboard;data dissemination;deep learning;deep learning algorithm;Development;Diagnosis;digital;Discrimination;Disease;Disease Progression;DNA;DNA Sequence Alteration;effective intervention;Environment;Environmental Hazards;environmental stressor;Etiology;experience;Exposure to;Face;Family Cancer History;Financial Hardship;follow-up;Genetic;Genetic Predisposition to Disease;genetic risk factor;genome-wide;Genomics;Genotype;Germ Lines;Gleason Grade for Prostate Cancer;Goals;Health;health care availability;Health care facility;health care service;Health Services Accessibility;high risk;high risk population;Hospitals;Hypertension;Image;Immunity;improved;Incidence;Inflammatory;Infrastructure;Insurance Coverage;Life Cycle Stages;Life Style;lifestyle factors;Link;Location;Longterm Follow-up;Louisiana;Malignant neoplasm of prostate;Maps;Measurement;Measures;Medicaid;Medical;medical specialties;Medicare;men;metropolitan;Michigan;modifiable lifestyle factors;Modification;Molecular;molecular phenotype;mortality;multiple data sources;Neighborhoods;neoplasm registry;New Jersey;New York;Non-Insulin-Dependent Diabetes Mellitus;Outcome;Pathogenicity;Pathologic;Pathologist;Patient Outcomes Assessments;Patient risk;Patients;Persons;Physical activity;Physicians;polygenic risk score;Population;population based;Poverty;Prevention;prognostic indicator;prognostication;progression risk;Progressive Disease;prospective;prostate cancer progression;Prostate Cancer therapy;Provider;PSA screening;public health priorities;Quality of life;Race;Recording of previous events;recruit;Recurrence;Reduce health disparities;Research;residence;resilience;Resources;Risk Factors;risk prediction;Role;Saliva;Sampling;satisfaction;segregation;Services;Smoking;social;Social Environment;social factors;social stress;social stressor;Sociology;Specimen;Stress;stressor;Structural Racism;Surveys;synergism;System;Testing;Texas;Time;tool;Training;Translational Research;Transportation;Trust;tumor;tumor microenvironment;Uninsured Medical Expense;Update;Variant;Visualization;Wait Time;whole slide imaging;Work

PROJECT_TITLE: Identifying factors associated with prostate cancer progression and survival in African American men: The RESPOND Cohort

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 TCRB-V (J1)]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences;Nutrition;Obesity

ORG_CITY: HOUSTON

ORG_DEPT: PEDIATRICS

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE We discovered a group of neurons in the forebrain, namely proenkephalin (Penk) neurons in the diagonal band of Broca (DBBPenk neurons), promote homeostatic feeding but suppress hedonic feeding, a “healthy eating” behavior that can ensure sufficient nutrition and at the same time avoid obesity. Here we propose to identify the circuitry mechanisms and further reveal the physiological relevance of these neurons, which will provide the necessary framework to develop therapeutic strategies towards treating obesity.

PI_NAMEs: XU, YONG  (contact)

PROGRAM_OFFICER_NAME: COOKE, BRAD

PROJECT_TERMS: Animal Behavior;Animal Feed;Animals;Anxiety;Appetite Stimulants;Behavior;Body Weight;cancer type;Cardiovascular Diseases;combat;comorbidity;Consumption;Diagonal Band of Broca;Diet;dietary;Eating;Eating Behavior;Enkephalins;Ensure;Environment;Equilibrium;Fatty acid glycerol esters;feeding;Feeding behaviors;Food;gain of function;gamma-Aminobutyric Acid;Healthy Eating;hedonic;Hunger;Hyperphagia;Hypothalamic structure;in vivo;Intake;Lateral;loss of function;Mediating;Medicine;Metabolic;Modeling;Mus;Negative Valence;neural;neural circuit;neurobiological mechanism;Neurobiology;Neurons;neurotransmission;Non-Insulin-Dependent Diabetes Mellitus;novel;nutrition;Obesity;obesity development;optogenetics;Peptides;Physiological;Play;Positive Valence;Prevalence;prevent;proenkephalin;Prosencephalon;Research;response;Role;segregation;sugar;Synapses;Testing;Therapeutic;Thinness;Time

PROJECT_TITLE: Forebrain Proenkaphalin Neurons Regulate Feeding

STUDY_SECTION: BNRS

STUDY_SECTION_NAME: Behavioral Neuroendocrinology, Neuroimmunology, Rhythms, and Sleep Study Section [BNRS]


ADMINISTERING_IC: CE

IC_NAME: NATIONAL CENTER FOR INJURY PREVENTION AND CONTROL

ORG_CITY: DAVIS

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: PROJECT NARRATIVE Between 25-50% of adolescents with mild traumatic brain injuries (mTBIs) have substantial mental health sequelae during their recoveries. We will use an experienced team of sites and investigators to develop a clinical tool to predict mental health sequelae in adolescents after mTBI. This tool will provide evidence for clinical decision-making, helping to reduce uncertainty amongst clinicians and decrease health disparities.

PI_NAMEs: NISHIJIMA, DANIEL KIDEN (contact);SLOMINE, BETH S

PROJECT_TITLE: RFA-CE-23-008, Development and Validation of a Clinical Tool to Predict Mental Health Sequelae After Mild TBI in Adolescents


ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

PHR: Project Narrative Firearm violence is a pervasive, preventable public health issue that disproportionately impacts Black youth and young adults due to structural racism in the form of systematic economic disenfranchisement. Economic security policies are promising primary prevention strategies for firearm violence that provide economic support to low-income families, including Black families, who experience persistent inequities in concentrated poverty and associated firearm violence. Our study proposes a series of complementary quantitative and qualitative analyses to evaluate both the effectiveness and potential underlying mechanisms of Temporary Assistance for Needy Families, Minimum Wage, Supplemental Nutrition Assistance Program, and Earned Income Tax Credit for preventing firearm violence among Black youth and young adults aged 10-34.

PI_NAMEs: LIVINGSTON, MELVIN D;WOODS-JAEGER, BRIANA  (contact)

PROJECT_TITLE: RFA-CE23-005 Evaluating Economic Security Policies to Prevent Firearm-Related Violence and Injuries among Black Youth


PI_NAMEs: KUROWSKI, BRAD G (contact)

PROJECT_TITLE: RFA-CE-23-008, Development of a Mental health Outcomes Screening Tool (MOST) after mild TBI in adolescents: The MOST-mTBI study


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Physical Rehabilitation;Rehabilitation

ORG_CITY: TEMPE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

ORG_STATE: AZ

PHR: PROJECT NARRATIVE In the past few decades, prosthetic hand technology has significantly improved, but rejection rates remain high. This proposal addresses three of the limitations of commercial myoelectric prostheses underlying prosthesis rejection: limited function, versatility, and robustness. We will test and compare the performance of a novel research myoelectric prosthetic hand, the SoftHand Pro, with a commercial hand prosthesis in a large number of individuals with upper limb loss in the laboratory and during daily activities to determine the extent to which the SoftHand Pro can address their unmet needs.

PI_NAMEs: SANTELLO, MARCO  (contact);ZHAO, KRISTIN DAIGLE

PROGRAM_OFFICER_NAME: BONNER, JOSEPH FRANCIS

PROJECT_TERMS: Activities of Daily Living;Address;Adult;Affect;Amputation;Arizona;battery life;biomechanical test;Clinic;Clinical Trials;Collaborations;Complement;Computer software;Crossover Design;Data;design;Digit structure;Disease;Disparity;Electromyography;Endowment;Feedback;feeding;Forearm;Genetic Complementation Test;Grant;grasp;Hand;Home;Human;improved;Individual;innovation;insight;Joints;kinematics;Laboratories;limb loss;Limb Prosthesis;Limb structure;Literature;Mechanics;Modification;Motor;Multi-Institutional Clinical Trial;Muscle;Myoelectric prosthesis;new technology;novel;Outcome Measure;Participant;Pattern;Performance;performance tests;Persons;Play;primary outcome;Prosthesis;Prosthesis Design;prosthetic hand;prototype;Quality of life;Randomized;Recreation;Reporting;Research;Research Personnel;response;Robotics;Role;satisfaction;secondary analysis;secondary outcome;Shapes;Site;Surveys;synergism;Technology;Testing;Time;tool;transradial amputee;Traumatic injury;United States National Institutes of Health;Universities;Upper Extremity;Weight;Work

PROJECT_TITLE: Toward use of the synergy-based SoftHand Pro for activities of daily living by transradial amputees: A multi-site clinical trial

STUDY_SECTION: MFSR

STUDY_SECTION_NAME: Motor Function, Speech and Rehabilitation Study Section[MFSR]


ORG_CITY: WORCESTER

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: Project Narrative Human T-cell leukemia virus type-1 (HTLV-1) is an oncogenic human retrovirus which has infected over 20 million people worldwide but lacks any vaccines or direct-acting antivirals. I will characterize the substrate specificity of HTLV-1 protease so that I can design inhibitors to mimic substrate interactions with the protease active site. I will design and characterize novel, resistance-preventing, potent inhibitors against HTLV-1 protease using structural and biochemical techniques.

PI_NAMEs: ZVORNICANIN, SARAH N (contact)

PROGRAM_OFFICER_NAME: MOITRA, KAROBI

PROJECT_TERMS: 2019-nCoV;Active Sites;Adult;Adult T-Cell Leukemia/Lymphoma;Advisory Committees;Advocate;Affect;Affinity;Amino Acid Sequence;analog;Anti-viral Agents;Aspartic Endopeptidases;Binding;Biochemical;Biological Assay;Carcinogens;chronic infection;Communities;Crystallography;design;Disabling;Disease;Environment;Evolution;experience;Family;Health;Hepatitis C virus;HIV;HIV Protease;HIV-1;HIV-1 protease;HIV/HCV;Human;Human T-lymphotropic virus 1;Individual;Infection;infection rate;Inflammatory;inhibitor;insight;Investigation;Laboratories;laboratory experience;Lead;Life Cycle Stages;meter;Molecular;molecular dynamics;Mutation;novel;Oncogenic;Patients;Peptide Hydrolases;Persons;Polyproteins;Population;Positioning Attribute;pressure;Prevalence;prevent;Protease Inhibitor;protease So;protein purification;Proteins;rational design;Relapse;Reporting;Research;Resistance;Retroviridae;SARS coronavirus;Series;Shapes;Site;skills;Specificity;Structure;Substrate Interaction;Substrate Specificity;T-Cell Lymphoma;Techniques;Testing;Training;Translating;Vaccines;Viral;Viral Proteins;Virus;X-Ray Crystallography

PROJECT_TITLE: Structure-based Antiviral Design against HTLV-1 Protease


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Clinical Research;Genetics;Human Genome;Rare Diseases;Scleroderma

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: Project Narrative Systemic sclerosis is a debilitating and lethal autoimmune disease whose pathogenesis is incompletely understood. The focus of this proposal is to identify the mechanisms by which a genetic variant in DNASE1L3 contributes to systemic sclerosis pathogenesis. This work will improve our understanding of the molecular underpinnings of systemic sclerosis, which can facilitate development of effective therapies.

PI_NAMEs: SKAUG, BRIAN  (contact)

PROGRAM_OFFICER_NAME: PARK, HEIYOUNG

PROJECT_TERMS: Acceleration;Amino Acids;Antigen-Presenting Cells;Apoptosis;Autoantibodies;Autoimmune Diseases;Award;biobank;Biochemical;Bioinformatics;Biological Assay;career;career development;Cell Physiology;Cell secretion;Cells;circulating DNA;Circulation;Data;Dendritic Cells;Deoxyribonucleases;design;Development;Digestion;Disease;DNA;Doctor of Philosophy;effective therapy;Environment;Enzyme-Linked Immunosorbent Assay;extracellular;extracellular vesicles;Foundations;Functional disorder;Gene Expression;Gene Expression Profile;Gene Expression Profiling;Genetic Polymorphism;genetic variant;Genomic DNA;genomic locus;Genomics;Goals;Helper-Inducer T-Lymphocyte;Human;Immune;Immunologics;Immunology;Impairment;improved;Institution;Interferon Type I;Interferons;Knockout Mice;Label;Laboratories;Lead;Length;Link;Lupus;Measurement;Mentors;Mentorship;Mitochondrial DNA;Molecular;Molecular Profiling;monocyte;mortality;mouse model;Mus;neutrophil;next generation sequencing;novel;Nucleosomes;Pathogenesis;Pathogenicity;Patients;Peripheral Blood Mononuclear Cell;Population;Research;Research Personnel;Rheumatism;rheumatologist;Risk Factors;Role;Sampling;single-cell RNA sequencing;Susceptibility Gene;Susceptibility to Systemic Sclerosis;System;Systemic Scleroderma;targeted treatment;Training;transcriptomics;Translational Research;Variant;Work

PROJECT_TITLE: Pathogenic effects of the DNASE1L3 R206C variant in systemic sclerosis

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Human Genome;Prevention;Psoriasis

ORG_DEPT: DERMATOLOGY

PHR: Project Narrative The proposed research is relevant to public health because it represents a new and alternative strategy to cure psoriasis without recurrence after stopping treatments. The proposed research is relevant to the part of the NIAMS Immunobiology and Immune Disease of Skin Program that pertains to studying the regulation of skin immune responses and immune tolerance induction with novel single-cell approaches.

PI_NAMEs: KIM, JAEHWAN  (contact)

PROGRAM_OFFICER_NAME: UNDALE, ANITA H

PROJECT_TERMS: Aftercare;Anatomy;Antibodies;Antigen-Presenting Cells;Biological;Biological Markers;Biological Products;Biopsy Specimen;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cell Communication;Cells;Chromatin;chronic inflammatory disease;Clinical;clinical application;Clinical Trials;combinatorial;cytokine;Data;Dendritic Cells;Digestion;Disease;Disease Progression;Disease remission;Dose;drug clearance;Emigrations;empowerment;Enzymes;Epidermis;FOXP3 gene;Gene Expression Profile;genetic signature;genomic data;Goals;healthy volunteer;Hour;Human;Immune;Immune response;Immune System Diseases;Immune Tolerance;Immunity;Immunobiology;Incubated;indexing;Injections;innovation;interleukin-23;keratinocyte;KLRB1 gene;Lesion;Machine Learning;melanocyte;Mentors;Messenger RNA;Microfluidics;Molecular;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;Natural Killer Cells;novel;Outcome;Pathogenicity;Pathologic;Patients;Pharmaceutical Preparations;Phase;Phenotype;Prediction of Response to Therapy;predictive modeling;prevent;programs;Psoriasis;Public Health;Recurrence;Recurrent disease;Regulation;Regulatory T-Lymphocyte;Research;restoration;single cell genomics;single-cell RNA sequencing;Skin;skin biopsy;skin disorder;T-Lymphocyte;Techniques;Testing;transcriptome sequencing;transcriptomic profiling

PROJECT_TITLE: A clinical trial for psoriasis with novel single-cell genomic techniques to understand regulatory immunity behind long-term disease remission off drug induced by short-term IL-23 inhibition