NIH_SPENDING_CATS: Aging;Assistive Technology;Bioengineering;Clinical Research;Disability Research;Physical Rehabilitation;Rehabilitation

ORG_DEPT: ENGINEERING (ALL TYPES)

PHR: Project Narrative The proposed research is relevant to public health because the proposed powered lower-leg prosthesis and its associated control strategy have the potential to extend longevity and dramatically improve quality of life of up to a million lower-limb amputees – a population expected to double by 2050 [1]. The project is relevant to the part of NIH's mission that pertains to developing fundamental knowledge that will reduce the burden of disability.

PI_NAMEs: LENZI, TOMMASO  (contact)

PROGRAM_OFFICER_NAME: NURMINSKAYA, MARIA

PROJECT_TERMS: Address;Affect;American;Amputation;Amputees;ankle prosthesis;Artificial Leg;Back Pain;biomechanical test;Biomechanics;Cardiopulmonary;Clinic;Clinical;clinical care;clinical outcome measures;Clinical Trials;Communities;Degenerative polyarthritis;design;Development;Device Designs;Devices;disability burden;Elderly;Engineering;Equilibrium;experimental study;foot;functional outcomes;Gait;Generations;Goals;Health;Healthcare;Home;Household;improved;improved mobility;Individual;Individuals with physical disabilities;Injections;innovation;joint loading;Joint Prosthesis;Knee;Knee Prosthesis;Knowledge;Laboratories;Leg;light weight;Limb structure;Longevity;Lower Extremity;Measures;Mediation;Mental Depression;Metabolic;Microprocessor;Mission;Motor;Movement;Muscle;novel;Outcome;Patients;Persons;Physiological;Population;Positioning Attribute;powered prosthesis;Prosthesis;Public Health;Quality of life;Ramp;Rehabilitation therapy;Research;Research Personnel;Residual state;Robotics;Speed;Technology;Testing;Time;Torque;Translations;Trauma;United States National Institutes of Health;Walking;walking speed;walking stability;Weight Gain;Work

PROJECT_TITLE: Lightweight Powered Prosthesis for above-knee amputees

STUDY_SECTION: MRS

STUDY_SECTION_NAME: Musculoskeletal Rehabilitation Sciences Study Section[MRS]


ADMINISTERING_IC: HL

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Physical Activity;Prevention;Social Determinants of Health

ORG_CITY: SEATTLE

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

ORG_STATE: WA

PHR: Increasing physical activity is critical to improving health, but the efficacy of physical activity interventions may be influenced by the context in which individuals are trying to increase this healthy behavior. Robust examination of pooled data from physical activity intervention trials across the U.S. will allow for a better understanding of how built and social environment factors affect physical activity outcomes and also how critical individual demographics impact these effects. Findings could rapidly and efficiently identify who will be responsive to existing physical activity interventions in what contexts and encourage innovation in changing interventions to better match environmental contexts of individuals seeking to increase physical activity.

PI_NAMEs: SAELENS, BRIAN E (contact)

PROGRAM_OFFICER_NAME: SHIROMA, ERIC JITSUO

PROJECT_TERMS: Adult;Affect;Age;Behavior;Behavioral Medicine;built environment;cardiovascular disorder risk;Cessation of life;Characteristics;Collaborations;Communities;Computer software;contextual factors;Counseling;Country;Data;Data Pooling;Demographic Factors;Demographic Impact;density;Development;Educational Intervention;Effectiveness of Interventions;efficacious intervention;Employment;Environment;Environmental Monitoring;Environmental Risk Factor;Ethnic Origin;exercise intervention;experience;follow up assessment;Geographic Locations;Health;Health behavior;Health Benefit;Home;Household;improved;inclusion criteria;Income;Individual;individual response;Informatics;innovation;Intervention;intervention effect;Intervention Trial;land use;Life Style;Link;Location;Maintenance;Malignant Neoplasms;Measurement;Measures;Moderate Exercise;Modification;Neighborhoods;Observational Study;Outcome;Participant;Physical activity;physical inactivity;Population;population health;post intervention;premature;Privacy;Race;Recommendation;Recreation;recruit;Research;scale up;Services;sex;skills;social;Social Environment;sociodemographics;Socioeconomic Status;Standardization;Testing;tool;United States;United States National Institutes of Health;user-friendly;walkability;Walking;Youth

PROJECT_TITLE: Are Interventions Supporting Physical ACtivity modified by the Environment (InSPACE)?

STUDY_SECTION: CIHB

STUDY_SECTION_NAME: Community Influences on Health Behavior Study Section[CIHB]


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer

ORG_CITY: AUSTIN

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

ORG_STATE: TX

PHR: NARRATIVE Our work will identify new ways to inhibit ERK signaling in tumors. This could lead to a new therapy to improve outcomes in patients with many different types of cancer.

PI_NAMEs: DALBY, KEVIN N (contact)

PROGRAM_OFFICER_NAME: AGYIN, JOSEPH KOFI

PROJECT_TERMS: adduct;Animal Model;anti-cancer;Antineoplastic Agents;Apoptotic;Binding;Binding Proteins;Biological;Biology;BRAF gene;cancer cell;cancer type;Cell Death;Cell Proliferation;Cell Survival;Cells;chemical kinetics;Chemicals;Clinic;clinical efficacy;clinical predictive model;Clinical Treatment;Clinical Trials;clinically relevant;Combined Modality Therapy;Computer Models;Crystallography;Cysteine;cytotoxic;design;Development;Disease remission;Drug Targeting;Electrons;Enzyme Kinetics;Evaluation;evidence base;Exhibits;Extracellular Signal Regulated Kinases;Family;FDA approved;Feedback;Future;Goals;Human;improved;improved outcome;in vivo;Induction of Apoptosis;inhibitor;inhibitor therapy;innovation;Innovative Therapy;insight;kinase inhibitor;Knowledge;loss of function;Malignant Neoplasms;MAP Kinase Gene;MAPK1 gene;MAPK3 gene;Mediating;Melanoma;member;Modality;Modeling;Molecular;Molecular Conformation;mutant;Mutation;Nature;NMR Spectroscopy;novel;novel strategies;novel therapeutics;Organoids;Outcome;Pathway interactions;Patients;Pharmaceutical Preparations;Pharmacodynamics;Phenotype;Phosphorylation;Phosphotransferases;pre-clinical;Pre-Clinical Model;Proteins;Ras Inhibitor;Ras/Raf;Reaction;Receptor Protein-Tyrosine Kinases;recruit;Research;Resistance;response;Signal Transduction;Site;standard of care;Testing;Therapeutic;Treatment Efficacy;tumor;tumor growth;tumor progression;Tumor Promotion;tumorigenic;Work

PROJECT_TITLE: Dual-Mechanism Allosteric Inhibitors of ERK Signaling

STUDY_SECTION: MIST

STUDY_SECTION_NAME: Molecular and Integrative Signal Transduction Study Section[MIST]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: SAN DIEGO

ORG_NAME: SAN DIEGO STATE UNIVERSITY

ORG_STATE: CA

PHR: RELEVANCE (See instructions): We are examining the role of the myosin molecular motor during aging of healthy and diseased muscles and are attempting to ameliorate muscle degeneration. To this end, we are 1) modeling aging human skeletal muscle by studying myosin with modifications found in human biopsies from aged individuals, 2) over- or under-expressing proteins that are dysregulated in two myosin-based progressive diseases of skeletal muscle and 3) studying mutant cardiac myosins that cause age-related dilated cardiomyopathy.

PI_NAMEs: BERNSTEIN, SANFORD I (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TERMS: Affect;Age;age related;Aging;aging population;aging related;ATP phosphohydrolase;Autophagocytosis;Biochemical;Biological Assay;Biopsy;Cardiac;Cardiac Myosins;Crystallography;Defect;Dilated Cardiomyopathy;Drosophila genus;Drosophila melanogaster;Enhancers;Exhibits;Fiber;Functional disorder;Genetic;Heart;Human;improved;In Vitro;in vivo;Inclusion Bodies;insight;Instruction;Locomotion;Mechanics;Methods;Modeling;Modification;Molecular Biology;Molecular Motors;Motility;Motor;Muscle;muscle degeneration;Muscular Atrophy;mutant;Mutation;Myocardium;Myopathy;Myosin ATPase;myosin storage myopathy;overexpression;Phenotype;Physiology;Progressive Disease;Property;protein aggregation;protein structure;Proteins;proteostasis;Rod;Role;skeletal disorder;Skeletal Muscle;Skeletal Muscle Myosins;Striated Muscles;Structural defect;Structure;Testing;Thick Filament;tool;Transgenic Model;Transgenic Organisms

PROJECT_TITLE: Genetics and Molecular Biology of Striated Muscle Myosin

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: EY

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: NEWARK

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: RUTGERS THE STATE UNIV OF NJ NEWARK

ORG_STATE: NJ

PHR: Relevance Repetitive visual stimulation (RVS) is a powerful driver of plasticity; just a few minutes of exposure can lead to a long lasting strengthening of neural responses. This could be beneficial to improve vision in amblyopia, in neuropsychiatric patients with reduced brain responses, or even in healthy subjects as a way to improve visual cognition. This project investigates a newly developed, improved method of RVS that has the potential to generate widespread behavioral improvements.

PI_NAMEs: KREKELBERG, BART  (contact)

PROGRAM_OFFICER_NAME: WIGGS, CHERI

PROJECT_TERMS: Amblyopia;Area;Attention;Behavioral;Brain;Chemosensitization;clinically relevant;Cognition;Cognitive deficits;Computer Models;Contrast Sensitivity;Data;density;Detection;Elderly;Electroencephalography;experimental study;extracellular;Frequencies;Goals;Health;Hour;Human;human subject;Human Volunteers;improved;insight;Laboratories;luminance;Methods;Modeling;neural;Neural Network Simulation;Neurons;neuropsychiatric disorder;neuropsychiatry;neuroregulation;nonhuman primate;Occipital lobe;Parietal;Patients;Pattern;Perception;Performance;Photic Stimulation;recruit;recurrent neural network;Research;response;Rodent;Short-Term Memory;spatial integration;Specificity;Techniques;Testing;Therapeutic Uses;tool;V1 neuron;Vision;Visual;Visual Acuity;visual cognition;Visual Cortex;Visual impairment;visual processing;visual stimulus;Visuospatial

PROJECT_TITLE: Noninvasive modulation of perception and cognition with flicker induced response modulation.

STUDY_SECTION: CP

STUDY_SECTION_NAME: Cognition and Perception Study Section[CP]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Biotechnology;Genetics;Nutrition

ORG_CITY: AUGUSTA

ORG_DEPT: BIOLOGY

ORG_NAME: AUGUSTA UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative One repeated feature of a number of longevity-extending interventions in animal models is that they result in reduced body size; in addition, a similar pattern in seen in natural genetic variation of wild type animals where small mice and dogs are longer lived than their larger counterparts. One pathway that has been found to be associated with age and body size is tryptophan metabolism to kynurenine; however, the direct of effects of tryptophan metabolism manipulation on aging and longevity are unknown. Here, I attempt to discover the metabolic changes that are associated with size and lifespan with specific focus on tryptophan degradation to kynurenine with the goal of developing a potential new target for lifespan and healthspan interventions.

PI_NAMEs: HOFFMAN, JESSICA MARIE (contact)

PROGRAM_OFFICER_NAME: FU, YI-PING

PROJECT_TERMS: Address;Affect;Age;age effect;Aging;Alabama;Animal Model;Animals;Biological Process;Biology of Aging;Body Size;Breeding;Callithrix;Calories;Canis familiaris;companion animal;Complex;data acquisition;Data Analyses;dietary;dietary manipulation;Disproportionately impacts women;Down-Regulation;Drosophila genus;Energy Intake;Enzymes;Essential Amino Acids;experience;experimental study;extend lifespan;Faculty;fly;Future;Genes;Genetic;genetic manipulation;Genetic Variation;Genotype;Goals;Health;healthspan;hormonal signals;Human;improved;Individual;Insulin;insulin signaling;Insulin-Like Growth Factor I;Intervention;Knowledge;Kynurenine;Life;life span;Longevity;Measures;Melatonin;member;Mentors;Mentorship;Metabolic;Metabolic Pathway;Metabolism;metabolome;metabolomics;Methionine;Molecular;Molecular Biology;mouse model;Mus;Nerve Degeneration;Neurohormones;novel;Nutrient;Pathway interactions;Pattern;Phase;Phenotype;Play;Positioning Attribute;Process;Production;Protein Biosynthesis;Research;Research Personnel;Research Project Summaries;Research Proposals;Role;Route;Serotonin;Shock;Signal Transduction;Sirolimus;skills;Somatotropin;Techniques;tool;Training;Translating;Tryptophan;Tryptophan 2,3 Dioxygenase;Tryptophan Metabolism Pathway;Universities;Variant;Wild Type Mouse;Work

PROJECT_TITLE: The metabolomic consequences of small size and long life


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Clinical Research;Dental, Oral, and Craniofacial Disease;Infectious Diseases

ORG_CITY: AMHERST

ORG_DEPT: DENTISTRY

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

ORG_STATE: NY

PHR: Narrative Candida albicans is a fungus that causes oropharyngeal candidiasis (thrush) in some people but is tolerated without symptoms in the mouth and gut in most individuals. We will use a mouse model to study host factors that lead to tolerance or disease including expression of enzymes (arginase and kallikreins) in the oral epithelium, and the recruitment of inflammatory cells including neutrophils and myeloid-derived suppressor cells (MDSC) that may help clear or dampen host response to fungal infection. We propose that MDSCs are a novel and unexplored arm of oral epithelial immunity that contribute to oral and gut tolerance, therefore understanding their function will guide future strategies to reduce the immune escape of C. albicans and add to our understanding of host tolerance.

PI_NAMEs: EDGERTON, MIRA  (contact)

PROGRAM_OFFICER_NAME: CHANDER, PREETHI

PROJECT_TERMS: Adoptive Cell Transfers;Adoptive Transfer;arginase;arm;Aspartic Endopeptidases;Bacterial Infections;Benign;Cancer Etiology;Candida albicans;Cells;chronic infection;Complex;Cues;cytokine;Disease;Enzymes;Epithelial Attachment;Epithelial Cells;Epithelium;Equilibrium;fungicide;fungus;Future;Goals;granulocyte;gut microbiome;Human;Hyphae;IL17 gene;Image;Immune;immune activation;Immune response;Immunity;Immunologic Factors;In Vitro;in vivo;in vivo evaluation;Individual;Infection;Inflammatory;Inflammatory Response;Integration Host Factors;Interleukin-1;Intestines;Invaded;Kininogenase;Leukotriene B4;LTB4R gene;Macrophage-1 Antigen;Measures;Mediating;Modeling;mouse model;Mucosal Immunity;mucosal site;Mucous Membrane;Mus;mutant;Mycoses;Myeloid-derived suppressor cells;Natural Immunity;neutrophil;Neutrophil Infiltration;novel;Nutrient;Oral;Oral candidiasis;Oral cavity;oral cavity epithelium;oral infection;Organism;oropharyngeal thrush;Outcome;overexpression;pathogen;Pathogenesis;pathogenic fungus;Peptide Hydrolases;Persons;Production;Proliferating;Proteins;recruit;Role;Shapes;Signal Transduction;Symptoms;T-Lymphocyte;Thick;Tissues;Tongue;Tumor Escape;Virulence

PROJECT_TITLE: Candida albicans oral infection shapes innate immunity and recruitment of myeloid-derived suppressor cells

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Cancer;Cancer Genomics;Clinical Research;Colorectal Cancer;Digestive Diseases;Genetics;Human Genome;Inflammatory Bowel Disease;Microbiome

ORG_CITY: CORAL GABLES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: NARRATIVE Ulcerative colitis patients have an increased risk of dysplasia and colon cancer because the constant inflammation of the colon causes damage to the intestinal lining. We believe that the bacteria in the colon and the immune system feed off each other to cause inflammation and more damage. We will use the most up to date methods and human specimens to tease apart how the immune system and the gut bacteria conspire to cause pre-cancerous lesions in colitis.

PI_NAMEs: ABREU, MARIA TERESA (contact)

PROGRAM_OFFICER_NAME: LUNSFORD, DWAYNE

PROJECT_TERMS: Animal Model;Bacteria;Bacterial Translocation;biobank;Biopsy;Cells;Characteristics;chemokine;Chronic;Colectomy;Colitis;colitis associated cancer;colitis-associated neoplasia;Colon;Colon Carcinoma;colon dysplasia;Colonic inflammation;cytokine;Cytometry;Data;deep sequencing;Defect;Dependence;Development;DNA Damage;dysbiosis;Dysplasia;Epithelial Cells;Epithelium;Feces;Fright;Functional disorder;Funding;Generations;Genetic Transcription;Germ-Free;gut bacteria;Human;Hydrogen Peroxide;Image;Immune signaling;Immune system;Inflammation;Inflammatory;intestinal epithelium;Intestines;Lesion;Link;Liver;Mediating;metabolome;metabolomics;Metagenomics;Methods;microbial;microbiome;Modeling;monolayer;mouse model;Mucous Membrane;Mus;Myeloid-derived suppressor cells;NADPH Oxidase;Natural Immunity;Oxidases;Oxidative Stress;Oxygen;Pathogenesis;Pathway interactions;Patients;Permeability;Predisposition;premalignant;prevent;Production;Proteobacteria;recruit;Research Personnel;Risk;Role;Sampling;Signal Induction;Signal Transduction;single-cell RNA sequencing;Specimen;T-Lymphocyte;Techniques;Testing;TLR4 gene;Translating;translational approach;tumor;tumor microbiome;Tumor Promotion;tumorigenesis;tumorigenic;Ulcerative Colitis;villin;Work

PROJECT_TITLE: Role of innate immunity and the microbiome in colitis-associated dysplasia

STUDY_SECTION: DHMI

STUDY_SECTION_NAME: Digestive System Host Defense, Microbial Interactions and Immune and Inflammatory Disease Study Section[DHMI]


ORG_CITY: OKLAHOMA CITY

ORG_NAME: OKLAHOMA MEDICAL RESEARCH FOUNDATION

ORG_STATE: OK

PHR: Project Narrative The work in these studies will generate new general knowledge of the presence and roles of the four known mammalian DRP1 receptors in the creation and maintenance of mitochondrial subpopulations in cells, as well as a new level of understanding of the importance of mitochondrial morphology for function. As such, it is directly related to the NIH and NIGMS missions to seek fundamental knowledge about how living systems behave.

PI_NAMEs: LEWIS, TOMMY L (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TERMS: Address;Adenosine Triphosphate;Automobile Driving;Calcium;Cell Physiology;cell type;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Coupled;design;Dynamin;Environment;experimental study;Genetic;high resolution imaging;Homeostasis;Image;in vivo;Knowledge;Label;Laboratories;Lipids;loss of function;Maintenance;Maps;member;Methods;Mission;Mitochondria;Molecular;Morphology;Mus;Muscle Fibers;National Institute of General Medical Sciences;Neurons;Organelles;Organism;Pathway interactions;Physiological;Population;Production;Proteins;Reactive Oxygen Species;receptor;Reporter;response;Role;Shapes;Technology;temporal measurement;Testing;two-photon;United States National Institutes of Health;Visualization;Work

PROJECT_TITLE: Molecular and cellular mechanisms regulating mitochondrial subpopulation dynamics and function in vivo

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-T(55)R]


NIH_SPENDING_CATS: Cancer;Colorectal Cancer;Digestive Diseases;Patient Safety

ORG_CITY: IRVINE

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: PROJECT NARRATIVE This proposal will seek to validate a 3D tumor-on-chip platform for the identification of novel anti-cancer drugs and drug combinations. Previous studies have used cells growing on plastic dishes, which fails to capture the complexity of a real tumor, thereby leading to low success rates in the drug screening pipeline.

PI_NAMEs: HUGHES, CHRISTOPHER C. W. (contact)

PROGRAM_OFFICER_NAME: COVELL, DAVID G

PROJECT_TERMS: 3-Dimensional;Adherent Culture;Adopted;analysis pipeline;Antibodies;Antineoplastic Agents;bevacizumab;Biological Assay;Blood Vessels;Breast;cancer cell;Cancer Model;capillary bed;Categories;Cell Line;Cells;Cetuximab;clinical predictors;clinically relevant;Colon;Colon Carcinoma;Colorectal Cancer;combinatorial;Combined Modality Therapy;Complex;Cultured Tumor Cells;Data;Data Set;design;Dose;Drug Combinations;Drug Interactions;Drug Screening;Drug Synergism;Extracellular Matrix;Fibroblasts;flexibility;Fluorouracil;Gene Expression Profile;Goals;Grant;Growth;Human;human model;In Vitro;in vivo;irinotecan;Leucovorin;Malignant Neoplasms;Modeling;monolayer;Mus;neoplastic cell;novel anticancer drug;novel drug combination;Nutrient;oxaliplatin;Pancreas;panitumumab;Pathway interactions;Patients;Penetration;Perfusion;Persons;Pharmaceutical Preparations;Pharmacotherapy;physiologic model;Physiological;Process;response;scale up;Signal Pathway;small molecule;sound;spheroids;Stromal Cells;success;synergism;Testing;tissue culture;Tissues;tumor;Tumor Biology;Tumor Cell Line;tumor growth;tumor progression;Vascular remodeling;Vascularization

PROJECT_TITLE: In search of synergistic drug interactions in cancer


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE The rapid expansion of the aging ethnic/racial and linguistic minority population is outstripping the capacity to offer disability prevention services necessary to respond to their needs. The proposed renewal project aims to test the effectiveness and implementation readiness of an enhanced mental health and physical disability prevention intervention, delivered by community- based staff in four languages. If proven effective, we will develop a dynamic toolkit to accelerate its dissemination and implementation.

PI_NAMEs: ALEGRIA, MARGARITA  (contact)

PROGRAM_OFFICER_NAME: JAIN, KRITI MUNJAL

PROJECT_TERMS: Acceleration;Address;Adopted;Adoption;Age;Aging;Area;Caring;Client;Clinic;Clinical;clinical research site;Clinical Services;Collaborations;Communities;community building;community clinic;Community Health Aides;community organizations;community setting;Consolidated Framework for Implementation Research;cultural competence;design;disability;Disability prevention;disability risk;Disparity;Dissemination and Implementation;dosage;effective intervention;Effectiveness;Effectiveness of Interventions;effectiveness testing;Elderly;Elements;emotional distress;Enrollment;Environment;ethnic minority population;Ethnic Origin;evidence base;Evidence based treatment;Exercise;Feedback;Florida;frailty;Funding;Geographic Locations;Grant;Health Professional;help-seeking behavior;human old age (65+);implementation barriers;implementation evaluation;implementation process;Implementation readiness;Improve Access;improved;Individual;innovation;interest;Intervention;intervention participants;Language;learning community;Limited English Proficiency;Linguistics;Maintenance;Massachusetts;Mental Depression;Mental disability;Mental disorders;Mental Health;Mental Health Services;Mind;Minority;Minority Groups;Modeling;Mood Disorders;mood symptom;National Institute of Mental Health;Neighborhoods;New Agents;New York;Not Hispanic or Latino;novel;older adult;Older Population;Outcome;Participant;Patients;Persons;Phase;Physical activity;physically handicapped;Population;prevention service;preventive intervention;programs;Provider;psychoeducation;Puerto Rico;Race;racial minority population;Recurrence;reduce symptoms;Reporting;Research;Resource-limited setting;Resources;Risk;self reliance;Services;Severities;Site;social stigma;Source;Spanish;substance use;success;Testing;Therapeutic;Training;treatment research;uptake;Work

PROJECT_TITLE: Building Community Capacity for Disability Prevention for Minority Elders

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Behavior and Social Science of Aging Study Section[NIA-S]


NIH_SPENDING_CATS: Biotechnology;Digestive Diseases;Genetics;HIV/AIDS;Hematology;Infectious Diseases;Liver Disease

PHR: Project Narrative This project will assess whether cells within the liver serve as viral reservoirs in HIV- infected individuals. The project will use novel molecular approaches to assess HIV sequences within these anatomic sites and whether they are replication competent. This information will provide a fuller understanding of how HIV is able to persist under antiretroviral therapy.

PI_NAMEs: STEVENSON, MARIO  (contact);THOMAS, EMMANUEL

PROGRAM_OFFICER_NAME: DOO, EDWARD

PROJECT_TERMS: Address;Adopted;Alleles;Anatomy;Antibodies;antiretroviral therapy;Area;Binding;Blood specimen;CD4 Positive T Lymphocytes;Cell Compartmentation;Cell membrane;Cells;Cellular Tropism;Characteristics;Clinical;design;Discrimination;Disease remission;Exhibits;Genetic Polymorphism;Genome;HIV;HIV-1;HIV/AIDS;Immune system;In Vitro;Individual;Infection;insight;Interruption;Kupffer Cells;Length;Libraries;Ligands;Liver;Location;Macrophage;Membrane;Methods;Molecular;molecular clock;Molecular Cloning;Myelogenous;Myeloid Cells;Nature;novel;novel strategies;personalized approach;Phenotype;Phylogenetic Analysis;Plasma;Plasma Cells;Polymerase;Proviruses;Recombinants;Research;Resources;Role;Sampling;Structure;Tissues;Transplantation;Variant;Viral;viral rebound;Viral reservoir;Viremia;Virion;Virus

PROJECT_TITLE: Defining a Role for Liver Myeloid Cells in Viral Persistence under ART


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Aging;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research

ORG_CITY: ATLANTA

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: EMORY UNIVERSITY

PHR: PROJECT NARRATIVE  Approximately one fourth of the adults in the U.S. suffer from multi-morbidity, experiencing two or more chronic cardio-metabolic diseases. For interventions to interrupt the progression to having multiple chronic conditions and disparities in multi-morbidity, it is necessary to understand how these unfold across adulthood. In this study, we will provide national estimates of the burden of multi-morbidity across adulthood, of the progression from one chronic disease to multi-morbidity, and of how trajectories of multi-morbidity contribute to health disparities.

PI_NAMEs: ARGESEANU CUNNINGHAM, SOLVEIG  (contact)

PROJECT_TERMS: Address;Adult;Affect;African American population;Age;Age of Onset;age related;aging related;Arthritis;Asthma;Birth;Cardiometabolic Disease;Cardiovascular Diseases;Caring;Chronic;Chronic Disease;clinical practice;Clinical Practice Guideline;cohort;Cohort Studies;Communities;Data;data infrastructure;Data Set;Dementia;Diabetes Mellitus;Differential Mortality;disability;disability risk;Disease;Disease Clusterings;Disease Progression;Disparity;disparity reduction;Economics;Elderly;Enrollment;epidemiology study;ethnic minority;Ethnic Origin;Europe;experience;follow-up;Gender;Geography;Goals;Guidelines;Health;Health and Retirement Study;health disparity;Healthcare;Heart Diseases;high risk;Hispanic;Hispanic Populations;Hypertension;Incidence;Individual;innovation;Institutionalization;Interruption;Intervention;Kidney Diseases;Life;Life Cycle Stages;Life Expectancy;lifetime risk;Liver diseases;Longitudinal Studies;Lung Diseases;Malignant Neoplasms;Measures;Medical Care Costs;Mental Depression;Modeling;Morbidity - disease rate;mortality risk;multiple chronic conditions;Myocardial Infarction;National Longitudinal Survey of Adolescent to Adult Health;National Longitudinal Survey of Youth;Nature;Obesity;older adult;Osteoporosis;panel study of income dynamics;Pattern;Persons;Policies;Population;Population Group;Premature Mortality;prevent;Probability;Procedures;progression risk;Quality of life;Race;racial minority;Reasons for Geographic And Racial Differences in Stroke;Research;Risk;Sentinel;sex;Stroke;Time;Work;working class

PROJECT_TITLE: Disparities in the burden and progression of multi-morbidity across adulthood

STUDY_SECTION: SSPA

STUDY_SECTION_NAME: Social Sciences and Population Studies A Study Section[SSPA]


ADMINISTERING_IC: AR

ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: ROCHESTER

ORG_DEPT: ORTHOPEDICS

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: The cellular mechanisms of fibrotic tendon healing are not well-defined, leading to a critical lack of therapeutic targets. Persistence of matrix-producing myofibroblasts is the dominant driver of tissue fibrosis and there is clear evidence that myofibroblast function depends on the fibroblast-lineage from which it is derived. In this proposal we will define lineage-specific contributions to myofibroblast fate and establish that disruption of NFB-mediated myofibroblast survival and persistence promotes regenerative tendon healing.

PI_NAMEs: LOISELLE, ALAYNA  (contact)

PROGRAM_OFFICER_NAME: MARQUITZ, ARON

PROJECT_TERMS: Ablation;Acceleration;Acute;Affect;antagonist;Apoptosis;Articular Range of Motion;Biomechanics;Cell Lineage;Cells;Chronic;Cicatrix;Clinical;Coculture Techniques;Collagen Type I;Communication;Data;Deposition;Environment;Exhibits;Extracellular Matrix;Feedback;Fibroblasts;Fibrosis;Flexor;Gene Expression Profile;healing;Heterogeneity;Immunophenotyping;Impaired healing;Impairment;improved;Inflammation;Injury;injury and repair;Macrophage;Maps;Mediating;migration;Molecular Profiling;mouse model;Mus;Myofibroblast;NF-kappa B;novel;p65;paracrine;periostin;pharmacologic;Phase;Phenotype;Play;Population;Production;Proliferating;Property;recruit;regenerative;regenerative healing;repaired;Reporter;restoration;Role;S100A4 gene;scleraxis;Signal Transduction;single-cell RNA sequencing;Site;System;Tendon Injuries;Tendon structure;Testing;therapeutic target;Time;time use;tissue repair;Tissue Sample;Tissues;translational potential;Work

PROJECT_TITLE: Modulating Cell-fate to Promote Regenerative Tendon Healing

STUDY_SECTION: SBSR

STUDY_SECTION_NAME: Skeletal Biology Structure and Regeneration Study Section[SBSR]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Congenital Heart Disease;Congenital Structural Anomalies;Heart Disease;Machine Learning and Artificial Intelligence;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Rare Diseases

ORG_DEPT: ADMINISTRATION

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: NARRATIVE: Congenital heart defects (CHD) are the most common birth defects, impacting ~1 in every 100 births and while patient outcomes have improved over time, morbidity and mortality remain high for some children, and significant variation exists across the ~120 U.S. congenital heart hospitals. Using a clinical registry containing detailed clinical data from virtually all U.S. congenital heart hospitals, we will apply Bayesian machine learning within a causal inference framework to best utilize the diversity of the data to improve CHD surgical quality assessments. Our proposed research will support national initiatives to improve quality and outcomes for children and families impacted in CHD and will also provide a framework that can be applied broadly to improve quality assessments across other fields.

PI_NAMEs: NORMAND, SHARON-LISE TERESA (contact);PASQUALI, SARA

PROGRAM_OFFICER_NAME: SCHWARTZ, BRYANNA NICOLE

PROJECT_TERMS: Accounting;Address;analytical method;Area;Bayesian learning;Birth;Calibration;Cardiac;Case Mixes;Child;Childhood;Clinical;Clinical Data;clinically relevant;Collaborations;Congenital Abnormality;Congenital Heart Defects;Congenital Heart Surgery;Critical Care;Data;Data Science;Data Set;Databases;density;Diagnosis;Discrimination;diverse data;Exclusion;Family;Heart;Heart Transplantation;high dimensionality;Hospitals;Hypoplastic Left Heart Syndrome;improved;improved outcome;interest;Lesion;Machine Learning;Measures;Methods;Modeling;Modernization;Morbidity - disease rate;mortality;operation;Operative Surgical Procedures;Outcome;Outcome Assessment;Patient risk;patient subsets;Patient-Focused Outcomes;Patients;PC4 Gene;Pediatric Hospitals;Physiological;primary outcome;Probability;programs;Registries;regression trees;Reporting;Research;Resources;response;Risk Adjustment;Risk Factors;Sample Size;secondary outcome;Societies;Source;surgery outcome;Testing;Thoracic Surgeon;Time;Uncertainty;Variant;virtual

PROJECT_TITLE: Modern Analytics to Improve Quality & Outcome Assessments Following Congenital Heart Surgery

STUDY_SECTION: HSQE

STUDY_SECTION_NAME: Health Services: Quality and Effectiveness Study Section[HSQE]


NIH_SPENDING_CATS: Clinical Research;Genetics;Infectious Diseases;Lung;Physical Injury - Accidents and Adverse Effects

ORG_CITY: GAINESVILLE

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: PROJECT NARRATIVE The American Burn Association estimates that ~450,000 people in the United States will suffer burn injury each year, resulting in ~3,500 deaths with concomitant inhalation injury increasing the morbidity and mortality. We have discovered that the transcription factor Nuclear Factor-Erythroid-2-Related Factor (NRF2) is essential for controlling the morbidity and mortality associated with burn injury but is not robust enough to control the immune dysfunction promoting long-term susceptibility to infection. Using animal models and clinical specimens, we will elucidate NRF2-driven cell specific mechanisms, test whether the activation state of NRF2 can predict patient outcome, and evaluate whether pharmacological activation of NRF2-driven pathways using novel microparticle formulations represent a viable therapeutic approach for the treatment of burn-injury induced immune dysfunction.

PI_NAMEs: CAIRNS, BRUCE A;MAILE, ROBERT  (contact)

PROGRAM_OFFICER_NAME: CHAO, CHIEN-CHUNG

PROJECT_TERMS: Acute;Acute Lung Injury;Address;Agonist;American;Animal Model;Anti-Inflammatory Agents;Antioxidants;Bacterial Infections;Binding;Biological Response Modifiers;Burn Centers;Burn injury;burn model;burn therapy;Cell Culture System;Cell Nucleus;Cell Physiology;Cells;Cellular Stress;Cessation of life;chemokine;Clinical;cohort;Combined Modality Therapy;Complex;cytokine;Data;Development;Dissociation;Drug Metabolic Detoxication;efficacy evaluation;Elements;Enterobacteria phage P1 Cre recombinase;Epithelial Cells;Formulation;FRAP1 gene;Genes;Genetic Transcription;Homeostasis;Human;Immune;immune activation;Immune system;Immune System Diseases;Immunologic Receptors;improved;Infection;infection risk;Infectious Agent;Inflammation;Inflammatory;Inhalation;Inhalation Burns;Injury;Knockout Mice;Knowledge;Lung;Macrophage;Mediating;Molecular;Morbidity - disease rate;mortality;mouse model;Mouse Strains;multimodality;Mus;neutrophil;novel;nuclear factor-erythroid 2;Outcome;oxidative damage;particle;Pathology;Pathway interactions;Patient-Focused Outcomes;Patients;Pattern;Persons;pharmacologic;Physiological;Pre-Clinical Model;predictive modeling;Predisposition;prevent;Primary Cell Cultures;Proteins;Pulmonary Edema;Reactive Oxygen Species;recruit;Regulation;Respiratory Tract Infections;response;Risk;risk prediction;Role;Saline;Sampling;Specimen;Superoxides;Technology;Testing;Therapeutic;Tissues;transcription factor;Transcriptional Activation;Translations;United States;Wild Type Mouse

PROJECT_TITLE: Multi-modal rescue of pulmonary NRF2-insufficiency after burn and burn + inhalation injury to regulate innate immune dysfunction

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Diabetes;Nutrition;Obesity;Prevention

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE This work aims to improve our country’s public health efforts to reduce the incidence of type 2 diabetes by testing a potentially effective but nutritionally different version of the widely disseminated National Diabetes Prevention Program (NDPP) for individuals with prediabetes. We hypothesize that a very low-carbohydrate NDPP will be a useful and safe option to reduce type 2 diabetes risk in adults with prediabetes.

PI_NAMEs: SASLOW, LAURA  (contact)

PROGRAM_OFFICER_NAME: CENTER, MAUREEN MONAGHAN

PROJECT_TERMS: 2 arm randomized control trial;acceptability and feasibility;Adult;adult obesity;American;Amputation;Blindness;Body fat;Body Weight;Body Weight decreased;Caloric Restriction;Carbohydrates;Centers for Disease Control and Prevention (U.S.);clinical practice;Clinical Trials;Communities;community partners;Country;COVID-19 mortality;design;Diabetes Mellitus;Diabetes prevention;diabetes prevention program;diabetes risk;Diet;dietary;dietary adherence;Dietary Practices;dietary restriction;Disease;Educational Curriculum;Educational process of instructing;Effectiveness;effectiveness testing;efficacy testing;evidence base;Fatty acid glycerol esters;follow up assessment;Foundations;glycemic control;Glycosylated hemoglobin A;Goals;Health;high risk;Hypoglycemic Agents;improved;Incidence;Individual;Inflammation;Intake;Intervention;Kidney;Lead;Life Style;Measures;Medicare;Methods;Michigan;Mission;multi-site trial;Myocardial Infarction;National Institute of Diabetes and Digestive and Kidney Diseases;Non-Insulin-Dependent Diabetes Mellitus;nutrition;Nutritional;Outcome;Overweight;Participant;personalized intervention;Persons;Pharmaceutical Preparations;Physical activity;pilot test;Population;Prediabetes syndrome;preservation;Prevalence;prevent;Prevention strategy;primary outcome;Principal Investigator;programs;Public Health;Randomized;randomized trial;Randomized, Controlled Trials;Recommendation;Research;Research Personnel;Resources;response;Review Committee;Risk;Risk Factors;Risk Reduction;secondary outcome;Site;Stroke;Testing;tool;treatment as usual;United States;Weight;Work

PROJECT_TITLE: Testing a very low-carbohydrate diet version of the Diabetes Prevention Program to reduce risk factors for type 2 diabetes

STUDY_SECTION: PRDP

STUDY_SECTION_NAME: Psychosocial Risk and Disease Prevention Study Section[PRDP]


ADMINISTERING_IC: DC

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Aging;Cardiovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hearing Loss;Hypertension;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research

ORG_CITY: Boulder

ORG_NAME: UNIVERSITY OF COLORADO

ORG_STATE: CO

PHR: NARRATIVE The proposed research is relevant to public health because it fills a gap in our understanding of modifiable determinants of acquired hearing loss. This work will characterize Black-White differences in cochleopathy associated with Stage 2 Hypertension, a chronic condition that is most prevalent in the Black population. This research will produce a positive impact through providing reliable data regarding the link between HTN and cochlear vulnerability and will support future development of timely audiological assessment and responsive interventions, especially in underserved populations.

PI_NAMEs: BAIDUC, RACHAEL REBECCA (contact)

PROGRAM_OFFICER_NAME: KING, KELLY ANNE

PROJECT_TERMS: Acceleration;Acoustics;Acquired Deafness;Adult;Affect;African American population;Age;Age Factors;age related;aged;Aging;Audiology;Auditory;behavior test;Behavioral;Black Populations;Black race;Blood Pressure;burden of illness;cardiometabolic risk;cardiometabolism;cardiovascular health;Cell Physiology;Chronic;Chronic Disease;Clinical;clinical development;Clinical Protocols;Cochlea;comorbidity;Data;Data Analyses;Data Collection;Development;Disability research;Disease;Early identification;Early Intervention;Enrollment;epidemiology study;ethnic minority;Ethnic Origin;Evaluation;Exclusion;experience;Frequencies;Functional disorder;Future;Goals;Guidelines;Health;hearing impairment;Hearing problem;Hearing Tests;High Prevalence;Human;Hypertension;hypertensive;Impaired cognition;Impairment;improved;Individual;innovation;interest;Intervention;Jackson Heart Study;Knowledge;Lesion;Link;Literature;Low Prevalence;Mathematics;Measurement;Measures;Medical;Melanins;men;Mental Depression;Methodology;Minority Groups;Minority Participation;Mission;Modeling;modifiable risk;Monitor;multidisciplinary;National Institute on Deafness and Other Communication Disorders;Neurosciences;noise exposure;Noise-Induced Hearing Loss;normotensive;older adult;otoacoustic emission;Outcome;Outer Hair Cells;Participant;Pathogenesis;Patients;Persons;Population;Predisposition;Presbycusis;Process;prospective;Protocols documentation;Public Health;Race;racial difference;racial minority;Rattus;Reporting;Research;Research Personnel;Research Priority;Risk;Risk Factors;Role;sex;sex as a biological variable;Sex Differences;Site;Statistical Models;Stria Vascularis;Testing;therapeutically effective;tool;Underserved Population;Woman;Work

PROJECT_TITLE: Assessment of Cochlear Dysfunction in Black and White Adults with Stage 2 Hypertension Using High-Frequency Distortion Product Otoacoustic Emissions

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


NIH_SPENDING_CATS: Genetics;Infectious Diseases;Malaria;Rare Diseases;Vector-Borne Diseases

ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: Contact PD/PI: Rijo-Ferreira, Filipa Project Narrative Malaria parasites invade, replicate and burst host’s red blood cells in a synchronized manner, leading to rhythmic fevers. The proposed research will investigate how malaria parasites process daily rhythms within their hosts to regulate the synchronized development. When parasite and host rhythms are mismatched, infection is disturbed, therefore, uncovering the mechanism by which malaria coordinate their 24h periodicity will have an impact on understanding and treating this deadly infection. Project Narrative

PI_NAMEs: RIJO-FERREIRA, FILIPA  (contact)

PROGRAM_OFFICER_NAME: AKACEM, LAMEESE DANA

PROJECT_TERMS: Address;Bacteria;Behavior;Bite;Blood;Blood Cell Count;burden of illness;Cell Cycle;Cell Cycle Completion;Cell division;Cells;Chronic;circadian;Circadian gene expression;circadian pacemaker;Circadian Rhythms;Compensation;Culicidae;Darkness;Data;Development;Disease;Dissection;Diving;Drops;Environment;Erythrocytes;Fever;fitness;Foundations;Gene Expression;Genes;Genetic;Genetic Transcription;global health;Goals;Hormonal;Hormones;Human;In Vitro;Infection;Invaded;Jet Lag Syndrome;Knowledge;Life;Life Cycle Stages;life span;Light;Malaria;malaria infection;Mammalian Cell;Measures;Metabolic;mouse model;Mus;Mutant Strains Mice;Mutation;next generation sequencing;novel;Nutrient;Nutritional status;Organism;Output;Parasite Control;parasite invasion;Parasites;Parasitic Diseases;Parasitic infection;Pathway interactions;Periodicity;Persons;Phase;Physiological;Plasmodium;Population;Principal Investigator;Process;Property;Recurrence;Research;Rodent;Rupture;Salivary Glands;Signal Transduction;Sporozoites;success;Symptoms;System;Technical Expertise;Temperature;Testing;transcriptome;transmission process;Wild Type Mouse;Work

PROJECT_TITLE: Elucidating the mechanism for malaria rhythmicity: an underlying circadian clock of the parasite


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Eye Disease and Disorders of Vision;Mental Health;Neurosciences;Rehabilitation

ORG_CITY: STANFORD

ORG_DEPT: PSYCHIATRY

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE Rehabilitation and recovery from neuropsychiatric illness depends on engaging mechanisms of neuroplasticity (the changes in synaptic connections between neurons in the brain), and a major regulator of neuroplasticity is the moment-to moment-state of the brain (attention, emotions, arousal, etc.), but this is poorly understood, especially in humans, and may be particularly important for plasticity-induction brain stimulation therapies like repetitive transcranial magnetic stimulation (rTMS), although this is rarely considered in practice. The goal of this research is to measure how attention (an experimentally tractable, well-understood, and disease- relevant brain state) regulates rTMS-induced neuroplasticity in two different parts of the human visual spatial attention circuit: visual cortex (the target of visual attention) and frontal eye fields (the cortical source of visual attention). These experiments will produce fundamental knowledge to augment the efficacy of rehabilitative neuromodulation therapies for visual disorders including hemineglect, scotoma, and amblyopia as well as sa range of other neuropsychiatric disorders (depression, addiction, attention deficit disorder, stroke, traumatic brain injury, chronic pain syndrome, and others).

PI_NAMEs: ASH, RYAN THOMAS (contact)

PROGRAM_OFFICER_NAME: CLAYTON, EDWIN C

PROJECT_TERMS: addiction;Address;Affect;Amblyopia;Animal Model;Animals;Area;area striata;Arousal;Attention;Attention Deficit Disorder;attentional modulation;authority;autism spectrum disorder;Bayesian Modeling;Behavior;Behavior Therapy;Behavioral;Biology;Blindness;Brain;brain control;cerebral visual impairment;Cerebrum;Chronic pain syndrome;Clinic;Clinical;Computer Models;Contrast Sensitivity;Data;Data Set;Development;Discrimination;Disease;Electroencephalography;Electrophysiology (science);Emotions;Environment;experience;experimental study;Feedback;Felis catus;frontal eye fields;Future;Goals;Human;Impairment;in vivo;inattention;insight;Knowledge;Lead;Learning;Left;Link;Magnetic Resonance Imaging;Measures;Mediating;Mental Depression;Mentors;Methods;Modeling;Motor Cortex;mouse model;neural;neural correlate;Neuronal Plasticity;Neurons;neurophysiology;neuropsychiatric disorder;neuropsychiatry;neuroregulation;Neurosciences;Noise;novel;Optics;Patients;Perception;Physiology;preconditioning;Process;programs;Psychophysics;Recovery;Regulation;Rehabilitation therapy;repetitive transcranial magnetic stimulation;Research;Research Personnel;Research Proposals;response;retinotopic;Role;Scotoma;Sensory;Signal Transduction;Source;Strabismus;Stress;Stroke;Study models;Synapses;Synaptic plasticity;Techniques;Testing;Time;Training;Traumatic Brain Injury;Treatment Efficacy;Vision;Vision Disorders;Visual attention;visual control;Visual Cortex;Visual evoked cortical potential;Visual Fields;Visual impairment;visual plasticity;visual processing;Visuospatial;Work

PROJECT_TITLE: Quantitative Electrophysiology to Link Neuroplasticity, Brain State, and Behavioral Change in Human Visual Cortex


NIH_SPENDING_CATS: Bioengineering;Biotechnology

ORG_CITY: CINCINNATI

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UNIVERSITY OF CINCINNATI

ORG_STATE: OH

PHR: Project Narrative  Voice disorders resulting from aberrant scar formation in the vocal folds are challenging to treat and result in long term dysfunction for patients. This project aims to quantify improvements in wound healing and tissue biomechanics for vocal fold scar using a novel dose- controllable, injectable therapeutic delivery loaded with corticosteroid. Long-term goals of this line of research are to develop a platform to optimize wound healing of the voice box through novel drug delivery approaches.

PI_NAMEs: DION, GREGORY ROBERT (contact);PARK, YOONJEE

PROGRAM_OFFICER_NAME: KOPF, LISA MARIE

PROJECT_TERMS: Ablation;Absorbable Implants;Address;Adjuvant;Adjuvant Therapy;Adrenal Cortex Hormones;Affect;Benign;biodegradable polymer;Biological Products;Biomechanics;capsule;Cell Therapy;Cicatrix;Clinical;clinically relevant;Communication impairment;cost;cyanine dye 5;Data;design;Development;Dexamethasone;digital imaging;Dose;Drug Delivery Systems;Drug Implants;drug release kinetics;Dyes;Dysphonia;effective therapy;Effectiveness;Encapsulated;Extravasation;Eye;Fibrosis;Fluorescence;Foundations;Functional disorder;Glucocorticoids;Goals;Growth;healing;Health Care Costs;Histologic;Histology;Immune response;immunoreaction;Implant;implant design;implant material;improved;in vivo;Inflammation;Inflammatory;Injectable;Injections;injured;Injury;innovation;Intervention;Intralesional Injections;kinetic model;Larynx;Lasers;Lesion;Light;Measures;Mechanics;Modeling;Mucous Membrane;nanoparticle;novel;novel therapeutics;Operative Surgical Procedures;Oral;Outcome;Patients;Persons;Pharmaceutical Preparations;Phonation;Postoperative Period;Pre-Clinical Model;predictive modeling;Procedures;Property;Provider;Publishing;Quality of life;repaired;Repeat Surgery;Research;response;side effect;Small Interfering RNA;Speed;Structure;Submucosa;System;Techniques;Technology;Testing;Therapeutic;Time;Tissues;Trauma;Treatment Cost;Treatment Efficacy;treatment optimization;vibration;vocal cord;Voice;Voice Disorders;Wages;Work;wound healing

PROJECT_TITLE: INJECTABLE, TUNABLE THERAPEUTIC IMPLANT TO REDUCE VOCAL FOLD SCAR

STUDY_SECTION: MFSR

STUDY_SECTION_NAME: Motor Function, Speech and Rehabilitation Study Section[MFSR]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Comparative Effectiveness Research;Dental, Oral, and Craniofacial Disease;Health Services;Opioid Misuse and Addiction;Opioids;Pain Research;Patient Safety;Pediatric;Prevention;Primary Health Care;Substance Misuse

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: High-risk medications for anesthesia, sedation and pain are frequently prescribed and administered by dentists to children and have resulted in serious unintended consequences, but unique challenges with prescribing high-risk medications to pediatric dental patients are not well understood. Understanding patterns of dental prescribing and factors associated with adverse safety outcomes can inform training models and interventions to improve evidence-based practice, ultimately decreasing risks of serious adverse events and mortality among children. Thus, this project is relevant to the NICHD high research priority to improve systems of care which can mitigate medical errors and advance child health.

PI_NAMEs: SUDA, KJ  (contact)

PROGRAM_OFFICER_NAME: ELWOOD, WILLIAM N

PROJECT_TERMS: Adolescent;Adult;Adverse event;adverse event risk;adverse outcome;Age;airway obstruction;American;Anesthesia procedures;Anti-Anxiety Agents;Attitude;Benzodiazepines;care systems;Caring;Case Study;Cessation of life;Child;Child Health;Child health care;Childhood;Chronic;Clinical;Clinical Trials;Communities;Conscious Sedation;Data;Decision Making;Dental;Dental Care;Dental Care for Children;Dental caries;Dental General Practice;Dentistry;Dentists;design;Development;Disease;Drug Prescriptions;early childhood;effectiveness testing;Emergency Care;emerging adult;Ensure;evidence base;Evidence based intervention;Evidence based practice;Exposure to;Future;General Anesthesia;General anesthetic drugs;Goals;Harm Reduction;High Prevalence;high risk;Hospitalization;human error;Hypoxemia;improved;Incidence;Infection;Inflammation;Intervention;Interview;Knowledge;Measures;Medical;Medical Care Team;Medical Errors;Medical History;medication administration;medication safety;Methods;Modeling;mortality;National Institute of Child Health and Human Development;Nurse Practitioners;Opioid;Opioid Analgesics;opioid misuse;opioid overdose;opioid use;Outcome Study;Pain;Pain management;Parents;patient safety;Patient-Focused Outcomes;Patients;Pattern;pediatric patients;Pediatrics;Perception;Pharmaceutical Preparations;Physician Assistants;Physicians;pilot test;poor health outcome;population based;practice setting;prescription opioid;Procedures;Provider;Research;Research Priority;Resources;Risk;risk perception;Risk Reduction;routine practice;Safety;safety outcomes;safety practice;Sampling;Sedation procedure;Serious Adverse Event;sociodemographic factors;Standardization;Testing;third molar extraction;Training;trend;urgent care;usability;Ventilatory Depression;wisdom tooth;Youth

PROJECT_TITLE: Pediatric Adverse Event Risk Reduction for High Risk Medications in Children and Adolescents: Improving Pediatric Patient Safety in Dental Practices


NIH_SPENDING_CATS: Digestive Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative Balancing stem cell renewal and progenitor differentiation in the intestine is critical for maintaining a robust epithelial lining with replete with highly specialized absorptive and secretory cells. We have discovered that the nuclear receptor Liver Receptor Homolog-1 (LRH-1, NR5A2) mediates stem cell survival while also driving differentiation of hormone producing enteroendocrine cells. This proposal investigates the mechanisms controlling the separate functional roles of LRH-1 in stem and differentiating cells, highlighting how unique cellular contexts can modulate nuclear receptor activity in healthy and disease states.

PI_NAMEs: BAYRER, JAMES  (contact)

PROGRAM_OFFICER_NAME: GREENWEL, PATRICIA

PROJECT_TERMS: Address;Adult;Autoimmune Diseases;Automobile Driving;base;Binding;Biochemical;Biological Models;Biology;Cell Differentiation process;Cell Lineage;Cell Maintenance;Cell Proliferation;Cell Survival;cell type;Cells;Chromatin;Complement;Complex;Coupled;CRISPR-mediated transcriptional activation;crypt cell;design;directed differentiation;Disease;drug development;Drug Receptors;Enteritis;Enteroendocrine Cell;Environment;Epithelial Cells;Epithelial Physiology;epithelial repair;epithelial stem cell;Epithelium;Epitopes;Equilibrium;Evaluation;Experimental Designs;follow-up;Funding;gastrointestinal epithelium;Genes;Genetic;Genetic Transcription;Goals;healing;Health;Hormones;in vivo;Infection;Inflammatory;Injury;injury recovery;insight;intestinal crypt;intestinal epithelium;intestinal injury;Intestines;Investigation;Knock-out;Knowledge;Liquid substance;Maps;Mediating;Modeling;Molecular;mouse model;Mucous Membrane;mutant;Natural regeneration;novel;NR5A2 gene;Nuclear Receptors;Organoids;Outcome;overexpression;pharmacologic;Pharmacotherapy;Physiology;pluripotency factor;Population;Positioning Attribute;Post-Translational Protein Processing;Process;Production;progenitor;programs;Property;receptor function;Regulation;repaired;Research;response to injury;restoration;Role;Secretory Cell;Shapes;Signal Transduction;stem;stem cell differentiation;stem cell division;stem cell exhaustion;stem cell expansion;stem cell population;stem cell survival;stem cells;stemness;Stereotyping;Sumoylation Pathway;Supporting Cell;Surface;Surveys;Technology;Therapeutic;Tissues;tool;transcription factor;Work

PROJECT_TITLE: Decoding LRH-1 Activity in Gut Regeneration and Differentiation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-A(90)]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cocaine;Drug Abuse (NIDA only);Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: NARRATIVE Cocaine addiction is a chronic, progressive, and compulsive disorder with cycles of craving and relapse to drug seeking, which are driven by powerful cue-drug memories. The proposed research will use neurobiological techniques to reduce the ability of cocaine-cue memories to induce relapse by altering memory reconsolidation processes. Novel behavioral methods combined with pharmacological and optogenetic tools will be used in rat models to destabilize cocaine-cue memories to subsequently reduce the ability of cocaine cues to induce relapse-like behaviors.

PI_NAMEs: TAYLOR, JANE R (contact)

PROGRAM_OFFICER_NAME: MOORE, HOLLY MARIE

PROJECT_TERMS: addiction;Anisomycin;attenuation;Behavior;Behavior Control;Behavioral;Chronic;Cocaine;cocaine cue;Cocaine Dependence;cocaine relapse;cocaine self-administration;Corpus striatum structure;craving;Cue-induced relapse;Cues;Data;design;Development;Disease;Dopamine;dopaminergic neuron;Dose;drug abstinence;drug seeking behavior;Drug usage;Expectancy;expectation;experience;experimental study;Exposure to;Female;garcinol;histone acetyltransferase;Human;inhibitor;innovation;Learning;male;Measures;Memory;memory retrieval;Methods;Midbrain structure;Modeling;neural;Neurobiology;Neurons;novel;novel strategies;optogenetics;Outcome;Pharmaceutical Preparations;pharmacologic;Pharmacotherapy;Population;Predisposition;prevent;Prevention strategy;Process;Protein Synthesis Inhibitors;Publishing;Rattus;Relapse;relapse prevention;Research;Retrieval;Role;Signal Transduction;Stimulus;Techniques;Therapeutic;therapeutic target;Time;tool;translational study

PROJECT_TITLE: Memory Destabilization and Cocaine-Cue Induced Reinstatement in Rat

STUDY_SECTION: BRLE

STUDY_SECTION_NAME: Biobehavioral Regulation, Learning and Ethology Study Section[BRLE]


NIH_SPENDING_CATS: Cancer;Prevention

ORG_CITY: BALTIMORE

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: Project Narrative Significant progress in detection and treatment has reduced cancer mortality rates; however, with over 1.7 million new cases and 600,000 deaths from cancer reported in 2019, it remains a major health concern in the US. Advances in our understanding of fundamental biological mechanisms that promote oncogenesis have progressed at an unparalleled rate and provide a seedbed for the novel therapeutic interventions. The current challenge is to close this widening gap between laboratory discoveries and their clinical applications in the fight against cancer. Inspiring and training the next generation of cancer researchers and oncologists is central to accelerate the translation of research breakthroughs into new diagnostics and therapeutics. Towards this goal, the Nathan Schnaper Intern Program in Translational Research at the University of Maryland Greenebaum Comprehensive Cancer Center integrates research, educational and clinical training components that build on its strong history to train the next generation of cancer researchers and oncologists.

PI_NAMEs: HASSEL, BRET A (contact)

PROGRAM_OFFICER_NAME: RADAEV, SERGEY

PROJECT_TERMS: Acceleration;Age Years;anti-cancer research;Biological;burden of illness;Cancer Biology;Cancer Detection;cancer education;cancer epidemiology;cancer risk;Cancer Survivor;cancer therapy;Cardiovascular Diseases;career;Career Choice;Caring;Cause of Death;Cessation of life;Clinical;clinical application;Clinical Oncology;clinical training;cohort;Comprehensive Cancer Center;Data;Death Rate;Detection;Disparity;Education;education pathway;Educational Curriculum;Educational Grants;experience;Exposure to;fighting;Fostering;Funding;Goals;Health;Human;human old age (65+);innovation;Institution;interest;Internships;Joints;Laboratories;Learning Module;Malignant Neoplasms;Maryland;Mentors;Mission;next generation;novel diagnostics;novel strategies;novel therapeutic intervention;novel therapeutics;Oncologist;Outcome;Patient-Focused Outcomes;peer networks;Population;Population Sciences;programs;Recording of previous events;recruit;Reporting;Research;Research Personnel;Research Training;Scientist;Seminal;success;survivorship;Talents;Training;Training and Education;translational cancer research;translational pipeline;Translational Research;tumorigenesis;undergraduate student;Universities;Workforce Development

PROJECT_TITLE: The Nathan Schnaper Intern Program in Translational Cancer Research

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


NIH_SPENDING_CATS: Kidney Disease

PHR: The proposed research is relevant to public health because it is focused on discovering new therapies for kidney diseases affecting how much water is in the body. Sometimes this process is not balanced, leading to diseases such as hypertension (too much fluid in the body) and dehydration (too much urine production). Our work is aimed at identifying basic mechanism in kidney cells that cause these diseases in order to develop drugs to cure them.

PI_NAMEs: BROWN, DENNIS  (contact)

PROGRAM_OFFICER_NAME: MULLINS, CHRISTOPHER V

PROJECT_TERMS: absorption;Actin-Binding Protein;Actins;Address;Affect;Animals;antidiuretic;aquaporin-2;arm;Biological Assay;Biological Products;Cell membrane;Cell Physiology;Cell surface;Cells;Cellular biology;Clinical;Clinical Treatment;Clinical Trials;cohort;Complex;Congestive Heart Failure;Cytoskeleton;Data;Defect;Dehydration;depolymerization;design;Development;Disease;Down-Regulation;Duct (organ) structure;EGF gene;Electrolytes;Endocytosis;enzyme activity;Epidermal Growth Factor Receptor;Epithelial Cells;equilibration disorder;Equilibrium;Erlotinib;Event;Exocytosis;ezrin;F-Actin;Failure;Follow-Up Studies;Funding;genetic regulatory protein;Goals;Growth Factor Receptors;Health;Homeostasis;Hypertension;Hyponatremia;Inherited;inhibitor;Ion Channel;Kidney;kidney cell;Kidney Diseases;Knowledge;Ligands;Link;Liquid substance;live cell imaging;Membrane;Modification;Molecular;novel;novel therapeutic intervention;novel therapeutics;Participant;Pathway interactions;Patients;Pharmaceutical Preparations;pharmacologic;Phosphorylation;Physiology;Play;Process;Production;protein transport;Proteins;Public Health;receptor;Receptor Activation;Receptor Cross-Talk;Receptor Signaling;Recycling;Regulation;Regulatory Pathway;Renal function;Research;Retrieval;Ribosomal Protein S6 Kinase;Role;RPS6KA gene;Signal Pathway;Signal Transduction;Specificity;superresolution microscopy;Techniques;therapeutic target;trafficking;Translating;Urine;Vasopressin Receptor;vasopressin resistant diabetes insipidus;Vasopressins;Water;water channel;water treatment;Work

PROJECT_TITLE: Cell Biology of Vasopressin-induced Water Channels

STUDY_SECTION: KUFD

STUDY_SECTION_NAME: Kidney and Urological Systems Function and Dysfunction Study Section[KUFD]


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Burden of Illness;Clinical Research;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Racial and Ethnic Minority Health Research;Social Determinants of Health

PHR: PROJECT NARRATIVE Despite recent gains in overall life expectancy in the US, racial/ethnic health disparities in older adults persist and are widening. The Affordable Care Act insurance coverage expansions have shown promise for reducing disparities in access and health, but the impact on middle-aged and older adults is less clear. The study will investigate whether the Affordable Care Act coverage expansions were associated with reduced racial/ethnic disparities in coverage, access to care, medical costs, use of care, and overall health for middle-aged and older adults.

PI_NAMEs: TIPIRNENI, RENUKA  (contact)

PROGRAM_OFFICER_NAME: CHATTERJI, MINKI

PROJECT_TERMS: access disparities;Adult;Affect;Affordable Care Act;Age;Aging;American;Area;barrier to care;Black American;Black Populations;Black race;burden of chronic illness;care costs;Caring;Childhood;Chronic;Chronic Care;Chronic Disease;Community Surveys;cost;critical period;Data;disability;Disadvantaged;Disease Management;Disparity;disparity reduction;Distress;Drug Costs;Economics;Eligibility Determination;Enrollment;ethnic disparity;ethnic health disparity;ethnic minority;Ethnic Origin;Ethnic Population;Event;experience;Exposure to;Financial Hardship;Financial Support;Funding;Future;Gender;General Population;Goals;Health;Health and Retirement Study;health care availability;health care disparity;health care service utilization;health disparity;health equity;Health Insurance;Health Services Accessibility;Health Status;Healthcare;healthy aging;Heterogeneity;Hispanic;Hispanic Populations;Hospitalization;human old age (65+);improved;Individual;innovation;Insurance Coverage;Interruption;Intervention;late life;Life;Life Cycle Stages;Life Expectancy;Link;Medicaid;Medicaid eligibility;Medical Care Costs;Medicare;Methods;middle age;Minority;Modeling;Natural experiment;Non-Prescription Drugs;older adult;Policies;population survey;Privatization;Race;racial disparity;racial health disparity;racial minority;racial population;Role;Socioeconomic Status;socioeconomics;Structural Racism;Study models;Time;Time Series Analysis;treatment effect;Uninsured Medical Expense;Vulnerable Populations;Work

PROJECT_TITLE: The Affordable Care Act’s Role in Aging Disparities Before and After Medicare Eligibility

STUDY_SECTION: HHD

STUDY_SECTION_NAME: Healthcare and Health Disparities Study Section[HHD]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Genetics;Lewy Body Dementia;Neurodegenerative;Neurosciences;Parkinson's Disease

PHR: Histone deacetylases (HDACs), a family of epigenetic enzymes that regulate gene expression by chemically modifying chromatin, are altered in Parkinson disease and dementia with Lewy bodies and may contribute to their development and their course. Employing [11C]Martinostat, the first radiotracer that labels HDACs in living humans, the overall goals of this proposal are (1) to evaluate brain HDAC levels and regional distribution with [11C]Martinostat in patients with Parkinson disease, Parkinson disease dementia, and dementia with Lewy bodies, compared to Alzheimer’s disease and normal control subjects; and (2) to determine how regional [11C]Martinostat binding at baseline and over time relates to motor, cognitive, and behavioral features and their progression as well as to amyloid burden in these diseases. Together, these efforts will clarify the contribution of regional brain dysregulation of HDAC epigenetic control of gene expression during life to Parkinson disease, Parkinson disease dementia, and dementia with Lewy bodies and their clinical features.

PI_NAMEs: GOMPERTS, STEPHEN N. (contact);WANG, CHANGNING

PROGRAM_OFFICER_NAME: ROVESCALLI, ALESSANDRA C

PROJECT_TERMS: Affinity;Age;aged;Alzheimer's Disease;Amyloid;Amyloid beta-Protein;Amyloid deposition;amyloid imaging;Anterior;Autopsy;Behavioral;behavioral impairment;Binding;Biochemistry;Biological Markers;Biometry;Brain;Brain Diseases;Brain region;Cells;Cessation of life;Chemicals;Chromatin;Chromosome Structures;Clinical;Cognitive;cognitive testing;Corpus striatum structure;Data;Data Set;Dementia;Dementia with Lewy Bodies;Denervation;Development;Discipline;Disease;disease model;Disease Progression;DNA;DNA Sequence;Dopamine;dopaminergic neuron;drug discovery;Environment;Environmental Exposure;Enzymes;Epigenetic Process;Family;Functional disorder;Gene Expression;Genetic;Genome;Goals;HDAC4 gene;Hippocampus;Histone Acetylation;Histone Deacetylase;Histone Deacetylase Inhibitor;Human;Image;Impaired cognition;Impairment;Interdisciplinary Study;Label;Lewy Bodies;Lewy Body Dementia;Lewy Body Disease;Lewy body pathology;Life;Life Experience;Light;Magnetic Resonance Imaging;Midbrain structure;Mitochondria;Modification;Motor;motor impairment;nanomolar;Neocortex;Neurologic;Neurologic Examination;neuropsychiatry;Neuropsychological Tests;Neurosciences;Occipital lobe;Parkinson Disease;Parkinson's Dementia;Participant;Pathologic;Pathology;patient population;Patients;Positron-Emission Tomography;Proteins;putamen;Radiochemistry;radiotracer;Research;research clinical testing;Research Personnel;Resources;response;Severities;Standardization;success;synuclein;synucleinopathy;Testing;Therapeutic;Time;Toxic effect;Visual Hallucination;β-amyloid burden

PROJECT_TITLE: Imaging epigenetic dysregulation in the Lewy body dementias with [11C]Martinostat

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: NARRATIVE Recent work from our groups and others has shown that cancer cells bearing mutations in genes controlling a process known as RNA splicing are exquisitely sensitive to drugs that block the machinery that carries out RNA splicing. Because the safety and efficacy of this specific class of drugs is not yet known, here we propose to study an additional means to target RNA splicing by inhibiting a process known as protein arginine methylation. This study may have great therapeutic potential because a number of drugs targeting protein arginine methylation are entering early phase clinical trials now.

PI_NAMEs: GUCCIONE, ERNESTO  (contact)

PROGRAM_OFFICER_NAME: VENKATACHALAM, SUNDARESAN

PROJECT_TERMS: Acute Myelocytic Leukemia;Alleles;Antisense Oligonucleotides;Arginine;cancer cell;cancer type;Catalysis;cell killing;Cells;Chronic Lymphocytic Leukemia;clinical development;curative treatments;Data;Disease;Drug Targeting;Dysmyelopoietic Syndromes;early phase clinical trial;efficacy evaluation;Evaluation;Event;Gene Expression;Genes;Genetic;Health;Heterozygote;In Vitro;in vivo;Individual;inhibitor;leukemia;Leukemic Cell;Malignant Neoplasms;Mediating;Methylation;Modeling;Molecular;mRNA Precursor;mutant;Mutation;Myeloid Leukemia;myeloid leukemia cell;novel therapeutic intervention;novel therapeutics;Patients;Pharmaceutical Preparations;pharmacologic;Phase;Phase I Clinical Trials;Phenotype;Point Mutation;preclinical development;Process;Protein Inhibition;Protein Methylation;Protein Splicing;Protein-Arginine N-Methyltransferase;Proteins;Proteome;Refractory;RNA methylation;RNA Splicing;RNA-Binding Proteins;RNA-targeting therapy;Safety;small molecule;Small Nuclear Ribonucleoproteins;snRNP Structural Core Protein;Solid Neoplasm;Spliceosome Assembly Pathway;Spliceosomes;synthetic lethal interaction;Therapeutic;Therapeutic Effect;Uveal Melanoma;Work

PROJECT_TITLE: Therapeutic targeting of RNA splicing catalysis through inhibition of Protein Arginine Methylation

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 2 Study Section[MCT2]


ADMINISTERING_IC: AI

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Bioengineering;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Tickborne Diseases;Vector-Borne Diseases

ORG_CITY: Baltimore

ORG_NAME: VECTECH, LLC

PHR: Project Narrative. Current tick identification methods are highly resource and labor intensive, requiring physical collection of specimens and subsequent identification of species, sex, life stage, and engorgement by an acarologist based on visual morphological inspection. Here we propose to advance a prototype deep learning system capable of instantaneously and accurately identifying twelve medically-relevant adult tick species with 98% accuracy for practical deployment in professional public health and the general public. The resulting products developed through this proposal will ultimately expand tick surveillance capability and capacity, and strengthen public health response to tick-borne diseases.

PI_NAMEs: GOODWIN, AUTUMN  (contact)

PROGRAM_OFFICER_NAME: COSTERO-SAINT DENIS, ADRIANA

PROJECT_TERMS: Acceleration;Adult;Adult women;advanced system;Algorithms;American;Area;artificial intelligence algorithm;Bar Codes;Classification;classification algorithm;Collaborations;Color;commercialization;Communities;Computer Vision Systems;convolutional neural network;Culicidae;Data;Data Set;Databases;deep learning;design;Development;Devices;Disease;DNA;Ensure;experience;fighting;General Population;Geography;Goals;Gravid;Health education;high risk;Human;human disease;Image;improved;Incidence;insight;Larva;Life;Lighting;Lyme Disease;male;Marketing;Medical;Methods;mobile application;Modeling;Monitor;Morphology;Nymph;Optics;Phase;Prevention;Process;prototype;Public Health;Quality Control;Reporting;Research;Resolution;Resources;response;sample collection;Scientist;sex;sexual dimorphism;Spatial Distribution;Specimen;Surveillance Methods;Surveillance Program;System;Systems Development;Taxonomy;Telephone;Testing;tick bite;Tick-Borne Diseases;Ticks;Time;tool;Training;Translating;transmission process;United States;Update;Vaccines;vector;vector control;vector management strategies;vector tick;Vector-transmitted infectious disease;Visual;Visualization;web site;Work

PROJECT_TITLE: High accuracy automated tick classification using computer vision


NIH_SPENDING_CATS: Aging;Arthritis;Behavioral and Social Science;Bioengineering;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Networking and Information Technology R&D (NITRD);Osteoarthritis;Physical Rehabilitation;Rehabilitation;Social Determinants of Health;Telehealth

ORG_CITY: NATICK

ORG_NAME: ALTEC, INC.

PHR: PROJECT NARRATIVE Older individuals with chronic musculoskeletal disorders face challenges in arranging in-person visits for their care due to the scarcity of resources or fear of viral transmission during the current global pandemic. While telehealth visits have become increasingly available through various video conferencing apps, existing technologies fail to provide the quantitative outcomes necessary for evidence-based practice. To overcome this shortcoming, we are developing an augmented reality (AR) platform for telehealth rehabilitation that uses depth-sensing camera technology available in consumer devices (e.g., a smartphone, laptop, or PC-based camera) and body-tracking algorithms integrated within a telehealth video-conferencing platform to deliver real-time measures of joint mobility, alignment, posture, balance, strength, and function that supports the mandate for more effective delivery of evidence-based telehealth rehabilitation.

PI_NAMEs: SHIWANI, BHAWNA  (contact)

PROGRAM_OFFICER_NAME: JOSEPH, LYNDON

PROJECT_TERMS: 3-Dimensional;Advanced Development;Age;Algorithms;American;Apple;Appointment;Architecture;Augmented Reality;Caring;Cellular Phone;Chronic;Clinic;Clinical;commercial prototype;Communication;Compensation;Computer software;Computer Vision Systems;Coupled;COVID-19;COVID-19 pandemic;dashboard;Data;Degenerative polyarthritis;demographics;Development;Devices;Disease;Elderly;Engineering;Environmental Risk Factor;Equilibrium;Equity;Evaluation;evidence base;Evidence based practice;Exercise;Face;Feedback;Floor;Focus Groups;Fright;Gender;General Hospitals;Group Meetings;Health;health care availability;health care delivery;health care disparity;health disparity;Health Insurance Portability and Accountability Act;Health Technology;Healthcare;healthy aging;Home;Home environment;Human;Incidence;Income;Individual;Infection;Interview;joint mobilization;Knee;Knee Osteoarthritis;Laboratories;laptop;life span;Location;Massachusetts;Measures;Medical;medical specialties;Monitor;mortality risk;Motion;Musculoskeletal;Musculoskeletal Diseases;Needs Assessment;Older Population;Operating System;Orthopedics;Outcome;Outcome Assessment;Outcome Measure;pandemic disease;Patient Self-Report;Patients;Performance;Persons;Phase;Physical assessment;Physical Examination;physical therapist;Population;Posture;Protocols documentation;prototype;Questionnaires;Race;racial disparity;Readiness;Rehabilitation Outcome;Rehabilitation therapy;remote assessment;Resources;response;Risk;rural area;SARS-CoV-2 variant;Secure;Social isolation;Socioeconomic Factors;socioeconomics;Specialist;Statistical Data Interpretation;suburb;Surveys;symposium;Tablets;Technology;telehealth;telehealthcare;Testing;Therapeutic Intervention;Time;tool;usability;Validation;videoconference;Videoconferencing;viral transmission;Visit;Visual;Visualization;Work

PROJECT_TITLE: Augmented Reality Platform for Telehealth Rehabilitation


NIH_SPENDING_CATS: Clinical Research;Kidney Disease;Patient Safety;Urologic Diseases

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PROJECT NARRATIVE Each year, over 100,000 patients require an endoscopic (i.e. minimally invasive) surgery for kidney stone disease in the United States. Approximately 25% of these patients require a repeat surgery for residual stone fragments, which can lead to obstruction, pain, kidney injury and urinary tract infections. This proposal creates a navigational system for use during endoscopic stone surgery with the potential to improve stone-free rates and prevent recurrent stone surgeries or stone complications for many patients.

PI_NAMEs: KAVOUSSI, NICHOLAS L (contact);OGUZ, IPEK

PROGRAM_OFFICER_NAME: KIRKALI, ZIYA

PROJECT_TERMS: 3-Dimensional;Address;Anatomy;Blood;Blood coagulation;Clinical;clinical care;clinical decision support;Complex;Computer software;Computer Vision Systems;cost;Data;deep learning;Development;Disease;experience;eye hand coordination;Future;Goals;Grant;Image;improved;Incidence;indexing;Injury to Kidney;Intervention;Intraoperative Complications;Kidney;Kidney Calculi;kidney surgery;Location;Manuals;Maps;Measurement;Memory;minimally invasive;Modeling;Monitor;Morbidity - disease rate;Multi-Institutional Clinical Trial;Obstruction;Operating Rooms;Operative Surgical Procedures;Optics;Outcome;Pain;Patients;Positioning Attribute;Postoperative Period;Prevalence;prevent;Procedures;Psyche structure;Recovery;Recurrence;recurrent infection;Repeat Surgery;Reporting;Research;Residual state;risk mitigation;Societies;statistics;success;Surgeon;System;Techniques;Technology;Testing;three-dimensional modeling;three-dimensional visualization;Time;Training;United States;Ureteral obstruction;Urinary Calculi;Urinary tract infection;usability;virtual;Visualization;X-Ray Computed Tomography

PROJECT_TITLE: A Navigational System for Endoscopic Kidney Stone Surgery


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: Juvenile justice officers experience exceptionally high levels of chronic workplace stress, leading to costly outcomes including depression, anxiety, and burnout. Mindfulness-based interventions (MBIs) improve each of these outcomes, and can be tailored and delivered to employees during their workdays via smartphone app. By adapting an existing MBI app for JJOs and conducting a feasibility clinical trial, this study will develop building blocks for high-impact, large-scale studies that systematically address the need for sustainable and scalable programming to improve health trajectories among the justice system’s frontline workers.

PI_NAMEs: KENDALL, ASHLEY D. (contact)

PROGRAM_OFFICER_NAME: JEAN-FRANCOIS, BEDA

PROJECT_TERMS: acceptability and feasibility;adaptive intervention;Address;Adolescent;Adult;adverse outcome;Affective;African American;Anxiety;Award;Benchmarking;Black race;burnout;Chicago;Chronic;Clinical Trials;clinically significant;Consolidated Framework for Implementation Research;cooking;cost;cost effective;cost outcomes;County;Coupled;Data;design;Development;Disparity;Ecological momentary assessment;Educational process of instructing;effectiveness trial;emotion dysregulation;emotion regulation;Emotions;Employee;Ethnic Origin;Ethnic Population;evidence base;experience;Face;feasibility trial;Frontline worker;Funding;Gender;Health;Health Benefit;health disparity;Health Promotion;Health Technology;high risk;Home visitation;Illness Days;implementation framework;implementation science;improved;Individual;informant;interest;Intervention;Interview;Investigation;Justice;juvenile justice system;Language;Latinx;Leadership;Meditation;Mental Depression;Mental Health;Methods;mHealth;mindfulness;mindfulness intervention;mindfulness meditation;negative affect;Outcome;Patient Self-Report;peer;Persons;Positioning Attribute;Procedures;Public Health;Race;racial population;Randomized;Recording of previous events;Reporting;Research;Resources;Schedule;Secure;Site;smartphone application;Source Code;Sterile coverings;Stress;stressor;Symptoms;System;Technology;Testing;Text Messaging;therapy design;Translating;United States National Institutes of Health;Work;Workplace;Youth

PROJECT_TITLE: Feasibility Trial of a Mindfulness-basedmHealth Intervention to Mitigate the Effects of Chronic Workplace Stress among Juvenile Justice Officers


NIH_SPENDING_CATS: Biotechnology;Congenital Structural Anomalies;Eye Disease and Disorders of Vision;Genetics;Neurosciences;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: MILWAUKEE

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: PROJECT NARRATIVE In this proposal, we aim to explore the recently presented cell culture model mimicking human whole eye development for its applicability in studies of a broad spectrum of ocular disorders, many of which lead to partial or complete vision loss. The development of this model is significant because it will provide a platform for testing a wide range of patient variants and assist in the identification of novel disease mechanisms and genetic diagnoses.

PI_NAMEs: SEMINA, ELENA V (contact)

PROGRAM_OFFICER_NAME: ARAJ, HOUMAM H

PROJECT_TERMS: Affect;Alleles;Animal Model;Aniridia;Anophthalmos;Anterior;Anterior segment dysgenesis;Aphakia;Appearance;Benchmarking;Biological Models;Blindness;Cataract;Cell Culture System;Cell Culture Techniques;Cell Lineage;cell motility;cell type;Cells;Cellular Morphology;Characteristics;Code;Coloboma;Complex;Cornea;Defect;Development;Developmental Gene;Developmental Process;diencephalon;Disease;disease model;Drainage procedure;Ectoderm;Evaluation;Eye;Eye Development;Eye diseases;Fostering;FOXC1 gene;FOXE3 gene;Gene Expression Profile;Generations;Genes;Genetic;genetic disorder diagnosis;Genetic Predisposition to Disease;genetic variant;Hip region structure;Human;human induced pluripotent stem cells;human pluripotent stem cell;In Situ Hybridization;Individual;innovation;insight;Iris;lens;Lens development;Measures;Mesoderm;Microphthalmos;model development;Modeling;Morphology;neural;Neural Crest Cell;Neural tube;Normal Range;novel;optic cup;Optic vesicle;Organoids;Pathogenicity;Pathway interactions;Patients;Phenotype;Process;protein expression;Proteins;Protocols documentation;Publishing;Reproducibility;Retina;Role;Self Assessment;Shapes;single-cell RNA sequencing;stem cells;Structure;Structure of retinal pigment epithelium;Surface Ectoderm;System;Testing;Time;Tissues;Transcript;transcription factor;Untranslated RNA;usability;Variant;Vertebrates;Vesicle;Visual Fields

PROJECT_TITLE: Exploring a new model to study developmental eye diseases

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CDB-M(02)M]


NIH_SPENDING_CATS: Autoimmune Disease;Celiac Disease;Digestive Diseases;Nutrition

ORG_DEPT: CHEMISTRY

PHR: NARRATIVE Celiac disease is a gluten-induced inflammatory disorder of the small intestine for which no non-dietary therapy exists at present. Recent clinical and nonclinical studies have identified transglutaminase 2 (TG2) as a promising drug target for celiac disease therapy, but critical gaps remain in our understanding of how TG2 interacts with gluten peptides as well as other proteins in the body. We will fill these knowledge gaps.

PI_NAMEs: JABRI, BANA ;KHOSLA, CHAITAN  (contact)

PROGRAM_OFFICER_NAME: SHEA-DONOHUE, TEREZ

PROJECT_TERMS: adduct;Affinity;Antigen Presentation;Antigen Presentation Pathway;Antigen-Presenting Cells;Antigens;B lymphocyte immortalization;Binding;Biochemical;Biological Assay;Biology;Celiac Disease;Cell surface;cell type;Cells;Chemicals;Clinical;Clinical Trials;Complex;Cultured Cells;Data;deamidation;Dendritic Cells;Development;dietary;Disease;Drug Targeting;Embryo;Endocytosis;Endosomes;Engineering;enzyme substrate;Epithelial Cells;Exhibits;extracellular;Fibroblasts;Glutamine;Gluten;Goals;Grant;gut inflammation;Histocompatibility Antigens Class II;HLA-DQ2;Human Herpesvirus 4;Immune Tolerance;Immunology;Inflammatory;inhibitor;innovation;Interleukin-15;Intestines;kidney epithelial cell;Kinetics;Knowledge;LDL-Receptor Related Protein 1;Lead;Ligands;Lipoprotein Receptor;Logic;Macroglobulins;Mediating;Methods;Modeling;Molecular;Molecular Analysis;Molecular Conformation;mouse model;Mouse Strains;Mucous Membrane;Mus;novel;Oral;oral tolerance;Pathogenesis;Pathogenicity;Pathway interactions;Peptide Hydrolases;Peptides;peptidomimetics;Pharmaceutical Preparations;Property;Protease Inhibitor;Proteins;Rattus;receptor;receptor expression;receptor mediated endocytosis;Reovirus;Reovirus Infections;Reporting;Research;Reverse engineering;Role;Small Intestines;Specificity;Structure;Substrate Specificity;T cell response;T-Cell Activation;T-Lymphocyte;T-Lymphocyte Epitopes;Testing;Therapeutic;tool;Toxic effect;Transgenic Mice;transglutaminase 2;uptake;Villous Atrophy

PROJECT_TITLE: Role of Transglutaminase 2 in Celiac Sprue

STUDY_SECTION_NAME: Digestive System Host Defense, Microbial Interactions and Immune and Inflammatory Disease Study Section[DHMI]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurosciences;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: PHILADELPHIA

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: NARRATIVE Adult hippocampal neurogenesis reflects the continuous preservation of neural stem cells in the mature brain. Using both animal and human models, understanding the origin and function of these neural stem cells can reveal new targets to enhance plasticity and prevent dysregulation due to developmental disorders, neural injury or degeneration.

PI_NAMEs: SONG, HONGJUN  (contact)

PROGRAM_OFFICER_NAME: LAVAUTE, TIMOTHY M

PROJECT_TERMS: 3-Dimensional;Address;Adopted;Adult;adult neurogenesis;Animal Model;Brain;Cells;Cues;Cytoplasmic Granules;Data;dentate gyrus;Development;developmental disease;Disease;Electrophysiology (science);Embryo;granule cell;Hippocampus;Human;human induced pluripotent stem cells;human model;information processing;Injury;insight;interest;Learning;Life;Memory;Modeling;Molecular;Mus;Natural regeneration;Nerve Degeneration;nerve injury;nerve stem cell;neural repair;neurogenesis;neuron development;Neuronal Plasticity;Neurons;Neurophysiology - biologic function;Newborn Infant;novel;optogenetics;Organoids;Population;postnatal;preservation;prevent;Property;Rodent Model;Series;Signal Transduction;Specific qualifier value;stem cell biology;stem cells;Techniques;temporal measurement;Transplantation

PROJECT_TITLE: Continuous Neurogenesis in the Mammalian Hippocampus


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Mental Health;Pediatric;Pregnancy;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

PHR: PROJECT NARRATIVE Inflammation during pregnancy is one pathway leading to adverse pregnancy outcomes, including preterm birth. Psychosocial stress during pregnancy is an important contributor to maternal inflammation levels; however, we have a limited understanding of how prenatal stress influences fetal inflammation and if fetal inflammation is reflective of maternal inflammation during mid-gestation. We will examine four prenatal stressors in relation to biomarkers of inflammation, measured in banked maternal serum, cord serum, and placentas collected during mid-gestation, and assess for quantitative relationships across the three matrices.

PI_NAMEs: EICK, STEPHANIE MARIE (contact);ROBINSON, JOSHUA FREDERICK

PROGRAM_OFFICER_NAME: GUMINA, DIANE LAURA

PROJECT_TERMS: adverse birth outcomes;adverse outcome;adverse pregnancy outcome;Affect;Biological;biological adaptation to stress;Biological Markers;Blood;California;chemokine;Child Health;clinical practice;cohort;Color;Communities;Corticotropin-Releasing Hormone;critical period;cytokine;Data;Development;developmental disease;Discrimination;Disparity;early pregnancy;Enzyme-Linked Immunosorbent Assay;epidemiology study;Equation;Ethics;Ethnic Origin;Etiology;experience;Exposure to;Factor Analysis;fetal;Fetal Development;Fetal Growth;Fetal health;Fetal Tissues;Fetus;Future;Health;healthy pregnancy;Human;IL6 gene;IL8 gene;Immune system;improved;Individual;Inflammation;Inflammation Mediators;Inflammatory;insight;Interferons;Intervention;Investigation;Knowledge;Link;Low income;low socioeconomic status;marginalization;marginalized population;maternal serum;Measures;Mediating;Modeling;Mothers;Occupations;Outcome;Participant;Pathology;Pathway interactions;Patient Self-Report;perceived stress;perinatal health;Persons;PGF gene;Placenta;Positioning Attribute;Pregnancy;Pregnancy Complications;pregnancy health;pregnant;premature;Premature Birth;Premature Labor;prenatal;prenatal stress;Proxy;Psychosocial Stress;psychosocial stressors;public health insurance;Questionnaires;Race;Receptor Protein-Tyrosine Kinases;Risk;Role;Sampling;San Francisco;Scientific Advances and Accomplishments;Second Pregnancy Trimester;Serum;Shapes;Signaling Molecule;social disparities;social stressor;Social support;Stress;Stressful Event;stressor;study population;Termination of pregnancy;Third Pregnancy Trimester;Time;Tissue Sample;Umbilical Cord Blood;Vascular Endothelial Growth Factor Receptor-1;Woman;women of color

PROJECT_TITLE: Prenatal stress exposures and fetal inflammation during mid-gestation

STUDY_SECTION: RPPH

STUDY_SECTION_NAME: Reproductive, Perinatal and Pediatric Health Study Section[RPPH]


NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision

ORG_CITY: ALBANY

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT ALBANY

PHR: PROJECT NARRATIVE Upon aging, nearly all the alpha-crystallins in the human eye lens eventually bind to the cell membrane leading to opacity and cataract formation. Age-related cataract has no cure at present. We subscribe to the hypothesis that primarily, alphaA-crystallin binds to the membrane. Using lens membrane mimics, we propose to examine the nature of this binding. We will also test the membrane-binding characteristics of age-related alphaA-crystallin modifications to understand how the binding process can be controlled to delay or mitigate lens opacity and age-related cataract.

PI_NAMEs: PANDE, JAYANTI  (contact)

PROJECT_TERMS: Affect;Age;age related;Aging;aging related;Binding;biophysical techniques;C-terminal;Cataract;Cell membrane;Characteristics;Cholesterol;Circular Dichroism;Client;Crystalline Lens;Crystallins;deamidation;Disulfides;Equilibrium;Heat shock proteins;Human;Individual;lens;Lens Fiber;Lens Opacities;lens transparency;Lipids;Liposomes;Literature;Measurement;Measures;member;Membrane;Membrane Lipids;Modification;Molecular;Molecular Chaperones;Molecular Weight;monolayer;mutant;Nature;oxidation;Phospholipids;Play;Population;Post-Translational Protein Processing;prevent;Process;protein aggregation;Protein Conformation;Protein Family;Proteins;Raman Spectrum Analysis;Recombinants;Rest;Role;Senile Cataract;Senility;Spectroscopy, Fourier Transform Infrared;Sphingomyelins;Structure;Techniques;Testing;α-Crystallins

PROJECT_TITLE: Probing the specific interactions of AlphaA- crystallin and its aging- and cataract-associated forms with lens cell membrane mimics

STUDY_SECTION: BDE

STUDY_SECTION_NAME: Biology and Development of the Eye Study Section[BDE]


NIH_SPENDING_CATS: Neurosciences;Obesity

ORG_NAME: NEW YORK UNIVERSITY

PHR: Project Narrative The development of strategies to prevent or treat obesity is among the highest priorities for the healthcare and research communities. Harnessing the potential of thermogenic fat to enhance energy expenditure offers an attractive strategy against obesity and metabolic diseases. This proposal aims to identify the molecular pathways that control the activation and expansion of thermogenic fat.

PI_NAMEs: SHAMSI, FARNAZ  (contact)

PROGRAM_OFFICER_NAME: SPAIN, LISA M

PROJECT_TERMS: Address;Adipocytes;adipokines;Adipose tissue;Adrenergic Agents;Adult;Affect;angiogenesis;axon guidance;Binding;Biological;blood perfusion;Blood Vessels;Body Temperature;Brown Fat;C-terminal;cancer type;Cardiometabolic Disease;cardiometabolism;Cardiovascular Diseases;Cause of Death;Cells;Cellular Phone;Chemicals;Child;Chronic;Co-Immunoprecipitations;combat;Communities;Data;Development;Diabetes Mellitus;Endothelial Cells;Energy Metabolism;Environment;Family;Fatty acid glycerol esters;Gene Delivery;Health;Health Priorities;Healthcare;Human;Immunohistochemistry;In Vitro;in vivo;in vivo Model;Indirect Calorimetry;insight;Length;Ligands;lipid biosynthesis;Lipolysis;Mediating;member;Metabolic Diseases;Methods;Modeling;Molecular;Mus;N-terminal;Nerve;nerve supply;Neurites;Norepinephrine;Obesity;obesity treatment;overexpression;Oxygen;Pathway interactions;Play;prevent;Process;progenitor;receptor;Regulation;Research;Risk;Role;Semaphorins;Signal Transduction;single-cell RNA sequencing;small hairpin RNA;spatiotemporal;Stimulus;Testing;Thermogenesis;Tissue imaging;Tissues;transcriptomics;United States National Institutes of Health;Vascular Endothelial Cell

PROJECT_TITLE: Regulation of Adipose Tissue Remodeling Through Axon Guidance Molecule Slit3

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


NIH_SPENDING_CATS: Cannabinoid Research;Contraception/Reproduction;Endocannabinoid System Research;Maternal Health;Pediatric;Pregnancy;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Women's Health Research

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

PHR: Narrative The role of cannabinoid/endocannabinoid signaling in placentation to support pregnancy is critical to the well-being of the newborn and mother. The study proposes to test that well-coordinated endocannabinoid signaling in cooperation with the cell polarity signaling is critical to normal placentation and any disturbances in this process, due to aberration of endocannabinoid signaling, may cause preeclampsia and/or preterm birth. The results may help draw public attention to potential adverse effects of excessive consumption of cannabis products during pregnancy.

PI_NAMEs: DEY, SUDHANSU K (contact)

PROGRAM_OFFICER_NAME: ILEKIS, JOHN V

PROJECT_TERMS: 2-arachidonylglycerol;Address;Adverse effects;Agonist;Analgesics;anandamide;antagonist;Arteries;Attention;Blood Vessels;Brain;Breeding;cannabinoid receptor;Cannabinoids;Cannabis;cell motility;Cell Polarity;cell type;Cells;Chorionic Gonadotropin;CNR1 gene;CNR2 gene;Consumption;Coupled;Cre driver;Critical Pathways;Defect;directional cell;early pregnancy;EGF gene;Embryonic Development;endocannabinoid signaling;Endocannabinoids;Endothelial Cells;Endothelium;Epithelium;Event;Exhibits;fetal;Fetal Growth Retardation;First Pregnancy Trimester;Giant Cells;Growth Factor;GTP-Binding Proteins;Guanosine Triphosphate Phosphohydrolases;Health;Hormones;Human;IGF2 gene;IGFBP1 gene;illicit drug use;implantation;In Vitro;in vivo;Inferior;interest;Invaded;Knowledge;Link;migration;Molecular;Mothers;mouse model;Movement;Mus;mutant;Neurosciences;Newborn Infant;novel;Oxygen;Pathway interactions;Personal Satisfaction;Placenta;Placentation;planar cell polarity;Play;Pre-Eclampsia;Pregnancy;Pregnancy Complications;Pregnancy Outcome;Pregnant Women;Premature Birth;Process;Prolactin;Property;protein complex;Proteins;Public Policy;Regulatory Pathway;Reproduction;Research;Research Personnel;Role;Signal Pathway;Signal Transduction;Site;Spiral Artery of the Endometrium;stem cell migration;stem cell model;Stromal Cells;subfertility;Testing;Therapeutic;Tissues;trophoblast;trophoblast stem cell;United States National Academy of Sciences;Uterus;Vascular blood supply;Villous;WNT5A gene

PROJECT_TITLE: Endocannabinoid Signaling during Early Pregnancy

STUDY_SECTION: CMIR

STUDY_SECTION_NAME: Cellular, Molecular and Integrative Reproduction Study Section[CMIR]