ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Autoimmune Disease;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: STORRS-MANSFIELD

ORG_NAME: UNIVERSITY OF CONNECTICUT STORRS

PHR: Project Narrative Hispanics adults with type 1 diabetes (T1D), despite their disproportionate burden of acute complications (hypoglycemia and diabetes ketoacidosis) and related emergency department visits, hospitalizations, and death, remain largely disenfranchised from continuous glucose monitoring (CGM), an efficacious technology to mitigate these inequities. To increase CGM uptake in low-income, Hispanic adults with T1D receiving diabetes management in federally qualified health centers (FQHCs), the proposed mixed-methods study, with a pilot randomized control trial (RCT), will assess the feasibility of our study protocol, including our multi-level intervention informed by the Socio-Ecological Model. If the proposed multi-level intervention is found to be feasible and RCT findings indicate the intervention, relative to the control condition, shows promise, we anticipate a large-scale, multi-site RCT to follow to provide rigorous evidence in favor of our CGM intervention model to improve T1D outcomes in vulnerable Hispanic adults receiving diabetes care in FQHCs.

PI_NAMEs: CHANNAMESETTY, VEENA ;NEWLIN, KELLEY  (contact)

PROJECT_TERMS: Acute;Adherence;Adult;Aptitude;Behavioral;Blood Glucose Self-Monitoring;care outcomes;Caring;Certification;Cessation of life;Characteristics;Clinical;Collaborations;Communities;community advisory board;community based participatory research;Community Healthcare;Connecticut;Continuous Glucose Monitor;cultural competence;Data;Data Collection;design;diabetes education;diabetes management;Diabetes Mellitus;dosage;Dose;Education;Emergency department visit;empowerment;Endocrinologist;Endocrinology;Enrollment;Equity;experience;Family;Family member;family support;Feasibility Studies;Federally Qualified Health Center;Focus Groups;Fostering;Funding;Future;Glucose;Goals;Group Interviews;health care model;health data;health inequalities;Health Personnel;Healthcare;Hispanic;Hispanic Populations;Hospitalization;Hypoglycemia;implementation intervention;improved;Incidence;Income;Individual;Inequity;Insulin;Insulin-Dependent Diabetes Mellitus;Insurance;Insurance Coverage;Intervention;intervention delivery;intervention participants;intervention refinement;Knowledge;Life;Low income;Measures;Medicaid;medical specialties;Methods;Modeling;Motivation;Not Hispanic or Latino;novel;Outcome;Participant;patient engagement;peer;peer support;Perception;Phase;phase 1 study;phase 2 study;Physicians;Physiological;Pilot Projects;pilot test;Poverty;Preparation;prevent;primary care provider;Procedures;Process;programs;Protocols documentation;Provider;psychosocial;psychosocial outcome;Quality of life;Randomized;randomized, clinical trials;Randomized, Controlled Trials;recruit;Reporting;Research;Schedule;Signal Transduction;Site;skill acquisition;skills;social health determinants;Social Network;Social support;Specialist;Target Populations;Technology;Testing;Time;Titrations;Training;Trust;Uninsured;uptake;Visit

PROJECT_TITLE: FQHC Intervention for CGM Uptake in Hispanic Adults with T1D


ADMINISTERING_IC: AG

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Clinical Research;Data Science;Genetics;Human Genome;Neurosciences

ORG_CITY: NEW YORK

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PI_NAMEs: MENON, VILAS  (contact)

PROJECT_TERMS: Adult;age group;age related;Biological;Biological Assay;biomarker identification;Blood;Brain;cell type;Cells;Central Nervous System;Cerebrospinal Fluid;Classification;computerized data processing;cytokine;Data;Data Analyses;Data Coordinating Center;data harmonization;data management;data modalities;Data Set;data standards;data visualization;Ensure;Gene Expression;Gene Proteins;genome-wide;Goals;high resolution imaging;human tissue;Image;image registration;imaging Segmentation;Indirect Immunofluorescence;Individual;Investigation;life span;Link;machine learning algorithm;Maps;Marker Discovery;member;Modality;Molecular;molecular phenotype;Molecular Profiling;Molecular Target;multi-scale atlas;multimodal data;multimodality;novel;novel marker;Play;Process;Proteomics;Resolution;Role;Sampling;senescence;senescent cell;Sequence Alignment;single nucleus RNA-sequencing;Skin;Spinal Cord;Spottings;Techniques;tissue mapping;Tissues;transcriptome;transcriptomics;Universities;Work

PROJECT_TITLE: Data Analysis Core

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-D]


ADMINISTERING_IC: LM

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Autoimmune Disease;Data Science;Digestive Diseases;Inflammatory Bowel Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety

ORG_CITY: SAN FRANCISCO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: Project Narrative Randomized controlled trials are the gold-standard for studying diseases and treatments but have many limitations including significant expense, limited generalizability, and small cohorts that are inadequate for studying subgroups. Electronic health records data contain rich data on large and representative cohorts, but they are susceptible to bias due to their observational and uncontrolled nature. We will develop new computational tools integrate these datasets and harness their distinct advantages, enabling us to study patient groups who weren’t included in major clinical trials and promote greater equity in healthcare.

PI_NAMEs: RUDRAPATNA, VIVEK ASHOK (contact)

PROGRAM_OFFICER_NAME: REDDY, GOUTHAM

PROJECT_TERMS: 3-Dimensional;Acceleration;algorithm training;Algorithms;Bayesian Network;Benchmarking;Biometry;California;career;career development;Chronic;Classification;Clinic Visits;Clinical Data;Clinical Research;Clinical Trials;cohort;Complex;computerized tools;cost;Data;data harmonization;data integration;Data Reporting;Data Science;Data Set;Dedications;Disease;Drug Approval;E-learning;Effectiveness;Elderly;Electronic Health Record;electronic structure;Eligibility Determination;Endoscopy;Equity;Exclusion;Food and Drug Administration Drug Approval;Future;Goals;Healthcare;heterogenous data;Immune System Diseases;improved;in silico;innovation;insight;Joints;Learning;learning strategy;Machine Learning;Malignant Neoplasms;Masks;Measurement;Measures;meetings;Mentors;Methods;Modeling;Natural Language Processing;Nature;New Drug Approvals;outcome prediction;patient health information;Patient Representative;patient subsets;Patients;Pattern;Performance;Pharmaceutical Preparations;Population;Predisposition;Pregnancy;Publishing;Race;randomized trial;Randomized, Controlled Trials;reconstruction;Recording of previous events;Research Subjects;Sample Size;San Francisco;Selection for Treatments;Semantics;Severities;Source;Structure;Subgroup;support tools;Symptoms;Testing;Text;Time;tool;Training;treatment effect;Treatment Effectiveness;Ulcerative Colitis;Uncertainty;Universities;Work

PROJECT_TITLE: A data science framework for transforming electronic health records into real-world evidence


PI_NAMEs: PHATNANI, HEMALI  (contact)

PROJECT_TERMS: 21 year old;3-Dimensional;Address;Adult;Age;Atlases;Biological;Biological Markers;Biological Models;Biology;Blood;Brain;brain tissue;cell type;Cells;Clinical assessments;cohort;computerized tools;Computing Methodologies;Data;Data Analyses;data integration;design;Elderly;Exhibits;experience;Experimental Models;Freezing;Gene Expression;Genetic Models;genome-wide;Goals;human tissue;Image;In Situ;in vitro Model;in vivo;Indirect Immunofluorescence;Individual;induced pluripotent stem cell;life span;Maps;middle age;Modality;Modeling;Molecular;Molecular Profiling;mouse model;multi-scale atlas;multimodality;Mus;novel;old mice;Organ;Organoids;pharmacologic;Phenotype;Physiological;Population;Prefrontal Cortex;Proteome;Proteomics;Research;Resolution;senescence;senescent cell;senolytics;single nucleus RNA-sequencing;Skin;spatial integration;Spinal Cord;Technology;Testing;tissue mapping;tissue preparation;Tissues;transcriptome;transcriptomics;Universities;validation studies;young adult

PROJECT_TITLE: Biological Analysis Core


ADMINISTERING_IC: CA

ED_INST_TYPE: UNIVERSITY-WIDE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Childhood Leukemia;Genetics;Hematology;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE Myelodysplastic Syndromes (MDS) and Acute Myeloid Leukemia (AML) are paradigmatic cancers of the blood system that have dismal clinical outcome and cure rates have not improved in 50 years for the majority of patients. Research has shown the existence and critical role of pre-leukemic stem cells (preL-SC) and their subclonal complexity in MDS and AML pathogenesis, progression, and therapeutic resistance. The proposed research will study preL-SC subclonal complexity in patient samples and murine models, identify mechanisms of transcriptional dysregulation governing preL-SC, and test novel pharmacological approaches directly targeting preL-SC-relevant mechanisms in MDS, AML, and related pre-malignant conditions.

PI_NAMEs: STEIDL, ULRICH  (contact)

PROGRAM_OFFICER_NAME: KLAUZINSKA, MALGORZATA

PROJECT_TERMS: Acute Myelocytic Leukemia;Age Years;cell growth regulation;Cells;Clinical;Disease;Disease remission;Dysmyelopoietic Syndromes;Dysplasia;Genetic Models;Genetic Transcription;Goals;Hematopoiesis;Hematopoietic;Hematopoietic Neoplasms;improved;inhibitor;leukemia;leukemic stem cell;leukemic transformation;Malignant - descriptor;Memory;Molecular;mouse genetics;mouse model;Multipotent Stem Cells;Myelogenous;novel;novel strategies;Outcome;Pathogenesis;Patients;pharmacologic;Play;Precancerous Conditions;Preleukemia;premalignant;Premalignant Cell;prevent;Process;progenitor;Property;Regulation;Research;Resolution;Role;Sampling;single molecule;stem;stem cell fate;stem cells;subclonal heterogeneity;System;Testing;Therapeutic Intervention;therapeutic target;therapeutically effective;therapy resistant;tool;transcription factor;Work

PROJECT_TITLE: Molecular and Cellular Regulation of Pre-Leukemic Stem Cells and their Therapeutic Targeting


ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: SACRAMENTO

ORG_NAME: CALIFORNIA DEPARTMENT OF PUBLIC HEALTH

PHR: Project Narrative FDA Laboratory Flexible Funding Model (U19) Cooperative Agreement, FOA PAR-20-105 The proposed projects that will be performed within California Department of Public Health, Food and Drug Laboratory Branch will greatly enhance the capacity and capabilities of California's human and animal food testing to support the State integrated food safety system. The application includes multiple tracks under Microbiology, Chemistry, and Special Projects disciplines. These projects, when properly funded, will provide quick emergency response testing and surge capacity in large scale events, produce large amount of data through surveillance activities to find contamination trends and identify emerging issues for food supplies, and expand the methodologies, types of analytes, and food matrices through method development and validation activities.

PI_NAMEs: KIANG, DAVID ;XU, DADONG  (contact)

PROGRAM_OFFICER_NAME: WINTER, RONALD

PROJECT_TITLE: Enhancement of California's Integrated Food Safety and Security System


ORG_CITY: YORK

ORG_NAME: ASSOCIATION OF FOOD AND DRUG OFFICIALS

ORG_STATE: PA

PHR: Project Narrative With funds and support from this grant, the Association of Food and Drug Officials (AFDO) members will continue to gain and share information at our annual conference. Topics discussed at this event can be used in a number of health and food safety programs throughout the country, increasing the success of consumer safety programs and initiatives.

PI_NAMEs: MANDERNACH, STEVEN  (contact)

PROGRAM_OFFICER_NAME: WEBB, SUZANNE

PROJECT_TITLE: U.S FDA Support for AFDO Educational Conference


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

ORG_CITY: LUBBOCK

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: TEXAS TECH UNIVERSITY

ORG_STATE: TX

PHR: Antibiotic Resistance Surveillance in Retail Food Specimens in Texas and Oklahoma PROJECT NARRATIVE  The goal of this study is to determine the prevalence of antimicrobial resistance among Salmonella, Campylobacter, E. coli and Enterococcus isolated from retail samples of chicken, turkey, beef and pork and from Enterococcus, Vibrio, Aeromonas and lactose fermenting bacteria from seafood purchased from grocery stores in Texas and Oklahoma using standardized methods so comparisons can be made to other national locations participating in the cooperative agreement. Achieving this goal will contribute to our understanding of the burden and magnitude of antibiotic resistant bacteria, in retail meat, poultry and seafood products distributed in the South-Central United States. Specifically, the results of this project will provide isolates for further characterization by national monitoring programs as well as novel sequencing data to support risk assessments, develop models and guidelines for antimicrobial stewardship, and create regional and national mitigation and control strategies to combat the spread and potential dangers derived from antimicrobial resistant (AMR) and multidrug resistant (MDR) foodborne pathogens that are present at the terminal end of the food supply.

PI_NAMEs: ECHEVERRY, ALEJANDRO  (contact)

PROGRAM_OFFICER_NAME: YOUNG, SHENIA


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Aging;Digestive Diseases;Liver Disease

ORG_CITY: MINNEAPOLIS

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: NARRATIVE The goal of this application is to elucidate the role of the lipid droplet and PLIN2 in the initiation and maintenance of the senescence phenotype. This work is significant as PLIN2 has clearly been shown to modulate inflammatory states but its ability to regulate the proinflammatory phenotype of senescence has yet to be established. By focusing on this novel niche in senescence, this proposal will lay the groundwork establishing PLIN2 and the LD as central to senescence and its associated inflammatory secretome, thus unveiling a novel mechanism by which senescence contributes to tissue dysfunction.

PI_NAMEs: DEVARAJAN, MAHIMA  (contact)

PROGRAM_OFFICER_NAME: FU, YI-PING

PROJECT_TERMS: Ablation;Affect;Age;Age Months;age related;Age related pathologies;Aging;aging related;aging related disease;Anabolism;Arachidonic Acids;Area;Attenuated;Automobile Driving;Binding;Biological;burden of chronic illness;Cell Aging;Cell Culture Techniques;Cell Cycle Arrest;Cells;chemokine;Chronic;cyclooxygenase 2;cytokine;Data;Disease;Eicosanoid Production;Eicosanoids;Enzymes;Etiology;Excision;experimental study;extend lifespan;Fatty Liver;Functional disorder;Goals;Growth Factor;hallmarks of aging;Healthcare Systems;healthspan;In Vitro;Individual;Inflammation;Inflammatory;inflammatory modulation;Inflammatory Response;insight;knock-down;Knock-out;Knockout Mice;Label;Leukotrienes;Lipid Binding;lipid metabolism;Lipids;Lipoxins;Literature;Liver Fibrosis;Maintenance;Malignant Neoplasms;Mediating;Metabolic;Metabolism;mitochondrial dysfunction;Modeling;Mus;Muscle;Neurodegenerative Disorders;nonalcoholic steatohepatitis;novel;Obesity;old mice;overexpression;Peptide Hydrolases;perilipin;Pharmaceutical Preparations;Phenotype;phenotypic biomarker;Phospholipase A2;Physicians;Play;Population;preference;Process;Prostaglandins;Proteins;Regulation;Research;response;Role;Scientist;senescence;senescence associated secretory phenotype;senescent cell;senolytics;Signal Transduction;Site;Stimulus;Surface;Testing;Thromboxanes;Tissues;Training;Work

PROJECT_TITLE: Investigating the Role of PLIN2 in Senescence

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-D(21)L]


ORG_CITY: ST. PAUL

ORG_NAME: MINNESOTA STATE DEPT OF HEALTH

PHR: This project will expand a database of foodborne pathogen sequences from food, animal and environmental sources that can be utilized for identification of disease outbreaks. Human cases can be compared the GenomeTrakr database. Similar sequences between human and food, animal or environmental samples can provide a hypothesis for the source of the illness.

PI_NAMEs: HAAN, JISUN  (contact)

PROJECT_TITLE: Whole Genome Sequencing of foodborne pathogens


ORG_CITY: TUMWATER

ORG_NAME: WASHINGTON STATE DEPARTMENT OF HEALTH

ORG_STATE: WA

PHR: Project Narrative Drug-resistant bacterial infections pose a serious and growing public health threat globally. The primary goal of our continued participation in the NARMS retail food surveillance program is to improve the detection and surveillance for antimicrobial resistance among enteric bacteria in raw retail meat commodities and seafood by providing data obtained from select stores in the state of Washington. Data obtained from investigations conducted by the lab will assist in developing pre-approval safety evaluation of new animal antibiotics, determining parameters for the antimicrobial use in veterinary medicine, and the ability of public health and partners to provide information for the development of new interventions to reduce resistance among foodborne bacteria. 1

PI_NAMEs: HIATT, BRIAN  (contact)

PROJECT_TITLE: Washington State Public Health Laboratories NARMS Cooperative Agreement Program Application 2021-2022. Retail Meat Surveillance.


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

ORG_CITY: BOSTON

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF MASSACHUSETTS BOSTON

ORG_STATE: MA

PHR: PROJECT NARRATIVE The University of Massachusetts, Boston (UMass Boston) and Dana-Farber/Harvard Cancer Center (DF/HCC) Partnership is committed to further developing a shared rigorous and collaborative transdisciplinary cancer and disparities-related research program that is primed for “Bridging the Divides: Innovations to Address Gaps in Cancer Disparities Research, Education, Outreach and Infrastructure.” Sophisticated research projects are proposed across several areas of basic biomedical and population sciences that will employ evidence and methods to converge upon and impact cancer and cancer health disparities at multiple levels of analysis. These projects, together with state-of-the-art Outreach and Research Education Cores and creative Research Design and Analysis Core and Genomics Cores, will serve to build research capacity and infrastructure at UMass Boston, expand the cancer disparities platform and community outreach programs at DF/HCC; and make, at an elevated level, significant advances to the science of cancer control.

PI_NAMEs: COLON-CARMONA, ADAN  (contact);MACOSKA, JILL A.

PROGRAM_OFFICER_NAME: WALI, ANIL

PROJECT_TERMS: Absenteeism;Address;Advanced Malignant Neoplasm;anti-cancer research;Area;Biology;Boston;Cancer Center;Cancer Control;cancer health disparity;Cancer health equity;Cancer Science;career;career development;Charge;Color;Communities;community engagement;Community Networks;community organizations;Community Outreach;Creativeness;Data;Data Set;Dedications;Discipline;Disparity;dissemination science;Education;education research;Ethnic Origin;experience;Experimental Designs;experimental study;Faculty;Foundations;Funding;Genomics;Goals;Government;Grant;Health Disparities Research;implementation science;Incidence;Infrastructure;innovation;Institution;Joints;Lasers;Leadership;Malignant Neoplasms;Massachusetts;member;Mentors;Methods;Modeling;Morbidity - disease rate;mortality;outreach;outreach program;Phase;Population;Population Group;Population Heterogeneity;Population Sciences;Postdoctoral Fellow;programs;Race;Research;research and development;Research Design;Research Infrastructure;Research Personnel;Research Project Grants;research study;Resource Sharing;Resources;Science;socioeconomic disparity;Solid;Source;Students;Training;translational model;translational potential;Underrepresented Populations;Underserved Population;United States National Institutes of Health;Universities

PROJECT_TITLE: 1/2 The University of Massachusetts, Boston - Dana-Farber/Harvard Cancer Center U54 Comprehensive Partnership for Cancer Disparities Research


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

PI_NAMEs: COLON-CARMONA, ADAN  (contact)

PROJECT_TERMS: Address;Administrator;Advisory Committees;Area;Basic Science;Boston;Budgets;Cancer Center;cancer health disparity;Cell Nucleus;Clinical Sciences;Collaborations;Colon;Color;Communication;community partners;Complex;Dedications;Development;Education;education research;Educational Activities;Electronic Mail;Ensure;equity, diversity, and inclusion;experience;Faculty;Foundations;Funding;Goals;Grant;Growth;Infrastructure;innovation;Institution;Institutional Review Boards;Joints;Lead;Leadership;Malignant Neoplasms;Massachusetts;meetings;member;Mentors;Mentorship;multidisciplinary;Newsletter;outreach;Participant;Population Sciences;Postdoctoral Fellow;programs;recruit;Research;Research Personnel;Research Project Grants;Resources;Role;Running;social media;Structure;success;symposium;synergism;Training;Universities;Update;web site

PROJECT_TITLE: Administrative Core


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Clinical Research;Infectious Diseases;Malaria;Orphan Drug;Pediatric;Prevention;Rare Diseases;Vector-Borne Diseases

ORG_CITY: BAMAKO

ORG_COUNTRY: MALI

ORG_FIPS: ML

ORG_NAME: UNIV OF SCIENCES, TECH & TECH OF BAMAKO

PHR: Seasonal malaria chemoprevention (SMC) is a prophylactic antimalarial regimen of sulfadoxine- pyrimethamine (SP) and amodiaquine (AQ) recommended by the World Health Organization (WHO) for preventing malaria episodes in children under 5 years of age in highly seasonal transmission settings. The purpose of the proposed study is to assess for potential long-term impact of SMC on malaria severity and immune response among children after they quit SMC program through a longitudinal cohort study. The study will provide data on the effectiveness of SMC in relation with compliance and valuable information on the burden of malaria when children are no longer in the program. It will also contribute to understanding the underlying biological basis of potential rebound of severe malaria and anemia after SMC and evidence basis for pursuing SMC strategy beyond current target age.

PI_NAMEs: TOURE, MAHAMOUDOU  (contact)

PROGRAM_OFFICER_NAME: RAO, MALLA R

PROJECT_TERMS: 4 year old;5 year old;8 year old;9 year old;Adopted;Africa South of the Sahara;Age;age group;age related;aged;Amodiaquine;Anemia;Anti-malarials;Antibody Response;Antigens;Area;Artemisinins;asexual;Binding;Biological;Blood;Chemoprevention;Child;Classification;cohort;Cohort Studies;Combined Modality Therapy;Communities;Control Groups;Country;Culicidae;Data;Development;Disease;Dose;Effectiveness;Eligibility Determination;Enrollment;Exposure to;Fever;Genetic Transcription;Genomics;Health;Hospitalization;Human;Immune response;Immunity;Immunologic Markers;Impairment;improved;Incidence;Infection;Insecticides;Intervention;Longitudinal cohort study;low and middle-income countries;Malaria;malaria infection;malaria transmission;Mali;Measures;Merozoite Surface Protein 1;Monitor;Morbidity - disease rate;mortality;Nested Case-Control Study;non-compliance;Outcome;Parasites;Phase;Plasmodium falciparum;Polymerase Chain Reaction;Population;Prevalence;prevent;Prevention program;Prevention strategy;programs;prophylactic;Prospective, cohort study;Pyrimethamine;Recommendation;Regimen;Reporting;Research;Risk;scale up;Seasons;Severities;Structure;Sulfadoxine;Surveys;Therapeutic;transmission process;treatment adherence;Treatment Protocols;trend;Withdrawal;Work;World Health Organization

PROJECT_TITLE: "Investigating the rebound effects of seasonal malaria chemoprevention (SMC) in Mali"

STUDY_SECTION: CRFS

STUDY_SECTION_NAME: Clinical Research and Field Studies of Infectious Diseases Study Section[CRFS]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Dissemination and Implementation Research;HIV/AIDS;Health Services;Prevention;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: NEW YORK UNIVERSITY

PHR: Project Narrative This study will utilize Multiphase Optimization Strategy (MOST) to optimize smoking cessation treatment for HIV clinical care by directly targeting patient barriers to quitting and clinical care barriers to reaching and effectively treating a broad heterogeneous population of smokers living with HIV. Given that over 75% of the 1.2 million persons living with HIV in the U.S. receive HIV clinical care annually, the results of this study will have a significant public health impact by optimizing a cost-effective, sustainable and immediately scalable smoking cessation package tailored specifically for the HIV clinical care context. Findings will also add to scientific knowledge by providing a clear basis for further improvement of cessation interventions for smokers living with HIV.

PI_NAMEs: CANTRELL, JENNIFER  (contact)

PROGRAM_OFFICER_NAME: CICCOLO, JOSEPH THOMAS

PROJECT_TERMS: Abstinence;Acute;Address;Administrator;Affect;barrier to care;Biochemical;Caring;Cause of Death;Cessation of life;cigarette smoking;Clinical;clinical care;Collaborations;comorbidity;Competence;Complex;Consolidated Framework for Implementation Research;cost;Cost Analysis;cost effective;cost effectiveness;Cost Measures;Counseling;Data;Decision Analysis;Disease;Economics;effective therapy;Effectiveness;effectiveness evaluation;Effectiveness of Interventions;Evaluation;evidence base;Face;General Population;Goals;Health;Health Personnel;Healthcare Systems;HIV;HIV/AIDS;Hospitals;implementation intervention;implementation outcomes;implementation process;improved;Individual;innovation;interest;Internet;Intervention;intervention cost;Intervention Trial;Interview;Knowledge;Life;long term abstinence;Longitudinal Studies;Measures;Medical;Methods;Motivation;motivational enhancement therapy;multi-component intervention;multiphase optimization strategy;Municipalities;National Cancer Institute;New York City;nicotine replacement;Nicotine Withdrawal;non-smoker;Outcome;patient-level barriers;peer coaching;Persons;Pharmacotherapy;Population;Population Heterogeneity;premature;Prevalence;Process;Proctor framework;Professional counselor;programs;Public Health;Readiness;Research;Resources;Risk;risk perception;Services;skills;Smoker;Smoking;smoking cessation;Smoking Cessation Intervention;social stigma;Social support;Structure;Surveys;Testing;Text Messaging;theories;Time;Tobacco;Tobacco Use Cessation;varenicline;Withdrawal

PROJECT_TITLE: Using Multiphase Optimization Strategy (MOST) to Optimize a Cost-effective, Sustainable and Scalable Smoking Cessation Package for Smokers in HIV Clinical Care

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


NIH_SPENDING_CATS: Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

PROJECT_TITLE: Planning and Evaluation Core


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Brain Disorders;Dementia;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences

ORG_CITY: CHAMPAIGN

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

ORG_STATE: IL

PHR: PROJECT NARRATIVE: Novel mass spectrometry-based technologies will be developed to create molecular atlases of the mouse brain impacted by Alzheimer’s Disease and healthy control. The proposed innovations in mass spectrometry imaging and single-cell mass spectrometry measurements and multiscale data fusion, in combination with unique mouse models of Alzheimer’s Disease, will reveal the temporal and spatial signatures of neuronal vulnerability in Alzheimer’s Disease and the effects of hippocampal neurogenesis on disease progression. The spatially and chemically resolved molecule portrait of healthy and Alzheimer’s Disease impacted brains will help elucidate the molecular mechanisms of disease progression and identify new biomarkers and therapeutic targets.

PI_NAMEs: LAM, FAN  (contact);LAZAROV, ORLY ;SWEEDLER, JONATHAN V.

PROGRAM_OFFICER_NAME: YANG, AUSTIN JYAN-YU

PROJECT_TERMS: 3-Dimensional;Address;Age;Aging;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Amyloid;Amyloid beta-Protein Precursor;Amyloid deposition;Animal Model;Area;Atlases;autosomal dominant Alzheimer's disease;Biochemical;Biological;biomarker identification;Brain;Brain Mass;Brain region;Cells;Characteristics;Chemicals;Cognitive;computer framework;Computing Methodologies;Data;data acquisition;data fusion;deep learning;Dementia;dentate gyrus;Deposition;Deterioration;Disease;Disease Progression;Dissociation;early onset;effective intervention;Enhancement Technology;entorhinal cortex;Exhibits;experimental group;experimental study;extracellular;Fourier Transform;frontier;Gender;Generations;Healthcare;Heterogeneity;Hippocampal Formation;Hippocampus;human model;human tissue;imaging approach;Imaging Device;imaging platform;Imaging Techniques;Imaging technology;Impairment;Inflammatory;innovation;insight;interest;Knowledge;Life;Lipids;Magnetic Resonance Imaging;Maps;mass spectrometric imaging;Mass Spectrum Analysis;Measurement;Memory;Memory Loss;Methods;Molecular;Molecular Bank;Molecular Profiling;mouse model;multimodality;multiscale data;Mus;Mutation;nestin protein;neurochemistry;Neurofibrillary Tangles;neurogenesis;neuron development;neuron loss;Neurons;new technology;novel;Pathologic;Phenotype;Play;Population;Portraits;presenilin-1;presenilin-2;reconstruction;Research;resilience;Resolution;restoration;Role;Sampling;single cell analysis;Slice;spatial relationship;Speed;Synapses;Tamoxifen;targeted treatment;Technology;therapeutic target;Tissue Model;Tissues;tool;Wild Type Mouse

PROJECT_TITLE: High-Throughput 3D Multiscale Mass Spectrometry Imaging for Understanding Neurochemical Heterogeneity in Alzheimer's Disease


ORG_CITY: SAN ANTONIO

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

PHR: PROJECT NARRATIVE - OVERALL The aging process plays a key role in the development of chronic disease, disability and the loss of independence. The goal of our program is to develop new interventions to promote healthy aging and maintenance of independence in older adults.

PI_NAMEs: STRONG, RANDY ;VOLPI, ELENA  (contact)

PROGRAM_OFFICER_NAME: SERRA, MONICA CHRISTINE

PROJECT_TERMS: 4 year old;Acceleration;Aging;aging process;aging related disease;Alzheimer's disease pathology;American;Awareness;Behavior Therapy;bench to bedside;Biology of Aging;Biometry;Callithrix;Capsicum;Cell Aging;Chronic Disease;Clinical;clinical center;Clinical Pharmacology;Clinical Research;Clinical Trials;Clinical Trials Design;Cognitive;Collaborations;Communities;data management;Development;Diamond;disability;drug development;dysbiosis;Education;education research;Elderly;Epigenetic Process;Exercise;first-in-human;Foundations;frailty;Funding;GDF8 gene;Gerontology;Geroscience;Goals;Grant;gut microbiome;hallmarks of aging;healthspan;healthy aging;Human;human disease;Immune;improved;Inflammation;Informatics;Infrastructure;innovation;Institution;Intervention;K-Series Research Career Programs;Knowledge;knowledge base;Laboratories;Leadership;life span;lifestyle intervention;Maintenance;Mediator;meetings;Metabolic dysfunction;Metformin;Methylene blue;microbiome;mild cognitive impairment;Mitochondria;Modeling;Monkeys;mTOR Inhibitor;multidisciplinary;nonhuman primate;nutrition;older adult;operation;oral microbiome;Oxytocin;Patients;pharmacologic;Pharmacology;Phase;Pilot Projects;Play;Policy Maker;pre-clinical research;Principal Investigator;programs;Qualifying;recruit;Research;Research Design;Research Personnel;Research Support;Resources;sarcopenia;Scientist;senescence;senolytics;Series;Services;Shock;Sirolimus;Site;skills;square foot;stem cell exhaustion;stem cells;stress reduction;symposium;Testing;Training;Translating;trial design;web site

PROJECT_TITLE: San Antonio Claude D. Pepper Older Americans Independence Center


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: ESCALERA, LIYA  (contact)

PROJECT_TERMS: Address;American;Area;behavioral and social science;Behavioral Sciences;Black Populations;Boston;Cancer Center;cancer health disparity;career;career development;Color;Communication;Communities;COVID-19 pandemic;Dana-Farber Cancer Institute;design;Development;Disabled Persons;Discipline;Discipline of Nursing;Disparity;Doctor of Philosophy;Education;education research;Educational Status;Enrollment;Ethnic Population;evidence base;experience;Faculty;Fellowship;Fostering;Genomics;Graduate Degree;graduate school;graduate student;Grant;Group Affiliation;Growth;Health;health communication;Health Disparities Research;health disparity;Healthcare;improved;Individual;Infrastructure;innovation;Institutional Racism;interest;Intervention;Investments;Knowledge;Latinx;Low Income Population;Malignant Neoplasms;Manuscripts;Massachusetts;Mentors;Methods;multidisciplinary;Native Americans;NCI Center for Cancer Research;outreach;Peer Review;personalized cancer therapy;Phase;physical science;Population;Population Heterogeneity;Postbaccalaureate;Postdoctoral Fellow;Preparation;Process;Productivity;programs;Publications;racial population;Research;research and development;Research Design;Research Personnel;Research Project Grants;research study;Science;Science Enrichment;Scientific Advances and Accomplishments;Scientist;skills;Students;success;Training;undergraduate student;Underrepresented Populations;Underrepresented Students;Universities;Work

PROJECT_TITLE: Research Education Core


NIH_SPENDING_CATS: Aging;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

PI_NAMEs: SHIREMAN, PAULA K (contact)

PROJECT_TERMS: Acceleration;active duty;Aging;aging population;American;Basic Science;Biology of Aging;Callithrix;Capsicum;career;career development;Career Mobility;Caring;Cities;Clinical;clinical center;Clinical Investigator;Clinical Research;Clinical Skills;Clinical Trials Design;Collaborations;County;Dedications;demographics;Development;Dimensions;Discipline;Discipline of Nursing;Doctor of Philosophy;drug development;Education;education planning;education research;Elderly;Environment;Evaluation;experience;Faculty;Fertilization;flexibility;Fostering;Funding;Future;Gerontology;Geroscience;Goals;Grant;Growth;Health;Health system;Healthcare;Healthcare Systems;healthspan;healthy aging;Hispanic;Hispanic Populations;Institution;Interdisciplinary Study;Intervention;Knowledge;Lead;Leadership;Medicine;Mentors;Military Personnel;Minority;Molecular;Monitor;multidisciplinary;next generation;older adult;Older Population;Participant;patient population;Patients;Pharmaceutical Preparations;Pharmacy facility;Phase;Physical activity;Positioning Attribute;Primates;Program Development;programs;Psychology;Qualifying;recruit;Research;research and development;Research Personnel;Research Training;Resources;Rodent;safety net;Science;Scientist;Shock;skills;South Texas;Structure;Testing;Training;Transducers;Translating;Translational Research;translational scientist;Underrepresented Minority;Universities;Veterans;Wages;Woman

PROJECT_TITLE: Research Education Component


NIH_SPENDING_CATS: Aging

PI_NAMEs: MUSI, NICOLAS  (contact)

PROJECT_TERMS: Adherence;Advisory Committees;Aging;aging related;aging related disease;American;Animal Experimentation;Basic Science;bench to bedside;Biological Models;Biology of Aging;Caenorhabditis elegans;Callithrix jacchus jacchus;Capsicum;Clinical and Translational Science Awards;clinical center;Clinical Sciences;cohesion;Collaborations;Communication;Communities;community advisory board;Drosophila genus;Education;education research;Elderly;Electronics;Environment;Ethics;Evaluation;experience;Fostering;Funding;Geroscience;Goals;Health;Human;improved;Infrastructure;innovation;Institution;interdisciplinary collaboration;Intervention;Knowledge;Leadership;Life Extension;meetings;Mentorship;Mission;Monitor;multidisciplinary;nonhuman primate;novel;operation;Performance;pharmacologic;Pilot Projects;Policies;pre-clinical;Preparation;prevent;programs;Progress Reports;Protocols documentation;Quality of life;Reporting;Research;Research Personnel;Research Support;Resources;Rodent;Science;Scientist;Services;Shock;skills;Structure;symposium;System;Testing;Thinness;Training Programs;Translating;Universities;Work

PROJECT_TITLE: Leadership Administrative Core


ORG_CITY: JUNEAU

ORG_NAME: ALASKA STATE DEPT/ENVIRONMTL CONSERVATN

ORG_STATE: AK

PHR: ASEHL Project Narrative-Overall SFY21-25 By maintaining and enhancing ISO/IEC 17025 for food testing, the Alaska State Environmental Health Laboratory (ASEHL) will continue to deliver both scientifically valid and legally defensible data to its clients. The clients, including the Alaska Food Safety and Sanitation (FSS) Program and U.S. FDA, will benefit by receiving enhanced customer service, consistent turnaround times, and little to no down time. Accreditation allows ASEHL to satisfy Standard 10 of the Manufactured Food Regulatory Program Standards (MFRPS) as the primary designated testing facility for the Food Safety and Sanitation Program (FSS). FSS is in full conformance to MRFPS standards.

PI_NAMEs: MCKINNEY, PATRYCE D (contact)

PROGRAM_OFFICER_NAME: CHRYSOGELOS, CHRISTINA

PROJECT_TITLE: Alaska Environmental Health Laboratory enhancing capacity and capability of food testing to support an integrated food safety system.


NIH_SPENDING_CATS: Aging;Clinical Research

PI_NAMEs: CLARK, ROBERT A (contact)

PROJECT_TERMS: Address;age related;Aging;aging related;American;Area;Behavior Therapy;bench to bedside;Biology of Aging;Callithrix;Cancer Center;Capsicum;Cells;Clinical Pharmacology;Clinical Research;clinical translation;Clinical Trials;Communities;design;Disease;Dissemination and Implementation;Doctor of Philosophy;education research;effective intervention;efficacy testing;Ensure;Environment;experience;Faculty;Financial Support;Funding;Geroscience;Goals;Grant;Health Sciences;healthspan;healthy aging;Homeostasis;Human;Infrastructure;innovation;Institution;Interdisciplinary Study;Intervention;Investments;Knowledge;knowledge base;Laboratories;Lead;Life Expectancy;Literature;Longevity;medical schools;Medicine;meetings;Mentors;Methods;model organism;Modeling;Monitor;nonhuman primate;novel;pharmacologic;Phase;Phase I Clinical Trials;Pilot Projects;Play;Positioning Attribute;pre-clinical;pre-clinical research;preclinical study;Primates;Process;programs;Publications;Qualifying;Research;Research Personnel;resilience;Resources;Science;Shock;side effect;stem cell gene therapy;Stress;Technology;Testing;Texas;therapy design;Thinking;Training;Translating;Translational Research;translational scientist;translational study;Translations;Universities;Work

PROJECT_TITLE: Pilot and Exploratory Studies Core (PESC)


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Cancer;Clinical Research;Dissemination and Implementation Research;HPV and/or Cervical Cancer Vaccines;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Immunization;Lung;Lung Cancer;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse;Underage Drinking;Vaccine Related

PI_NAMEs: DONALDSON, SHERRY TIFFANY (contact)

PROJECT_TERMS: 19 year old;Address;Adolescence;Adolescent;Adolescent and Young Adult;adolescent health;Age;Age Years;Alcohol consumption;anti-cancer research;Behavior;Black race;Boston;Cancer Center;Cancer Control;Cancer Control Research;cancer health disparity;cancer prevention;Cancer Prevention Intervention;cancer risk;career;Collaborations;Communities;community advisory board;community collaboration;community engaged research;community engagement;Community of Practice;community organizations;community partners;community-centered;Consultations;Dana-Farber Cancer Institute;Data;Development;Early Intervention;Education;education research;emerging adulthood;Equity;ethnic minority;ethnic minority population;Evidence based intervention;experience;Goals;Health;health care availability;health care service;Health Promotion;healthy weight;Human Papilloma Virus Vaccination;Human Papilloma Virus Vaccine;implementation science;Inequity;Infrastructure;innovation;Institution;Internships;Intervention;Latino;Link;Literature;Low income;Low Income Population;Malignant Neoplasms;Massachusetts;Methods;Minority Groups;Modeling;next generation;outreach;Persons;Population;prevent;Prevention strategy;programs;racial minority;racial minority population;Research;Research Design;Research Methodology;Research Project Grants;Science;Services;Shapes;structural determinants;Students;theories;Tobacco use;Training;underrepresented minority student;underserved community;Universities;Work;Youth

PROJECT_TITLE: Outreach Core


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics;Kidney Disease;Orphan Drug;Pediatric;Rare Diseases

ORG_CITY: WEST LAFAYETTE

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: Lowe syndrome is a lethal disease characterized by cataracts at birth, mental retardation and kidney problems that unfortunately lead to early death of affected children. Although this genetic condition was described almost 70 years ago, there is no specific treatment against available to patients. However, this project will change that scenario by testing 4 candidate drugs (including FDA-approved compounds) capable of restoring activity to some Lowe syndrome protein patient variants and reverting cellular phenotypes.

PI_NAMEs: AGUILAR, RUBEN CLAUDIO (contact)

PROGRAM_OFFICER_NAME: MENDLEY, SUSAN RUTH

PROJECT_TERMS: Active Sites;Address;Adolescence;Affect;Affinity;Age;Algorithms;Allosteric Site;Animal Model;Behavior;Binding;Biochemical;Biological Models;Birth;candidate selection;Cataract;Cell Line;Cessation of life;Child;cilium biogenesis;Complement;conformer;design;Dextrans;Disease;drug action;drug candidate;Enzyme Kinetics;Enzymes;Equilibrium;experimental study;FDA approved;Genes;Genetic Diseases;Glaucoma;In Vitro;Investigation;Kidney;Kidney Calculi;kidney cell;Kidney Failure;Lead;Lipids;Maps;Measurement;Mental Retardation;Missense Mutation;Modeling;Modification;Molecular Conformation;mutant;Mutate;Mutation;Nature;novel therapeutic intervention;Oculocerebrorenal Syndrome;Organoids;Oxalates;patient subsets;Patients;Pharmaceutical Preparations;Phenotype;Phosphoric Monoester Hydrolases;Process;Proteins;Proteinuria;Publishing;remediation;Renal function;Research;Risk;Safety;Series;small molecule;Structure;Symptoms;Techniques;Testing;Therapeutic;Therapeutic Agents;Therapeutic Index;Toxic effect;Toxicology;translational impact;uptake;Variant;Zebrafish

PROJECT_TITLE: Restoring Ocrl1 function in Lowe Syndrome and Dent-2 disease

STUDY_SECTION: XNDA

STUDY_SECTION_NAME: Xenobiotic and Nutrient Disposition and Action Study Section[XNDA]


NIH_SPENDING_CATS: Aging;Biomedical Imaging;Cancer;Patient Safety;Precision Medicine;Prevention;Prostate Cancer;Urologic Diseases

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: PROJECT NARRATIVE While prostate-specific antigen (PSA) testing is used commonly in early detection programs for prostate cancer, a single test result may be unreliable due to the tendency of PSA levels to fluctuate (both biological and analytical variation). False-positive PSA elevations are a cause of significant concern that may lead to anxiety, unnecessary antibiotic use, additional and costly clinical-work up with imaging, and/or risky, invasive prostate biopsies. We will analyze blood samples and clinical data from the world's largest randomized trials of prostate cancer screening and treatment—the United States Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial, the Swedish Göteborg population-based screening trials (Göteborg-1 and Göteborg-2), and the United Kingdom's Prostate Testing for Cancer and Treatment (ProtecT) trial—as well as biomarker and clinical data from the Multiethnic Cohort (MEC), to better understand these fluctuations in PSA levels, how to distinguish between aggressive and insignificant prostate cancers, and when to perform prostate biopsy.

PI_NAMEs: EASTHAM, JAMES A (contact)

PROGRAM_OFFICER_NAME: ZHU, CLAIRE

PROJECT_TERMS: Affect;Aftercare;Age;alpha 1-Antichymotrypsin;Antibiotics;Anxiety;Attention;Attenuated;Biological;Biological Markers;Biopsy;Blood;Blood specimen;Blood Tests;blood-based biomarker;cancer biomarkers;Cancer Detection;cancer risk;Cessation of life;chymotrypsin;Clinical;clinical care;Clinical Data;clinical decision-making;clinical practice;cohort;Cohort Studies;Colorectal;Colorectal Cancer;Complex;cost;Data;Decision Making;Detection;Diagnosis;diagnostic value;Disease;Early Diagnosis;Elderly;Ensure;Ethnic Origin;evidence base;Future;Genes;Genetic Variation;Goals;Guidelines;Head;head-to-head comparison;Human;Image;improved;Individual;individual variation;innovation;insight;Kinetics;Kininogenase;Knowledge;Ligands;Liquid substance;Lung;Magnetic Resonance Imaging;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant Neoplasms;Measurement;men;middle age;molecular marker;Monitor;MSMB gene;multi-ethnic;Neoplasm Metastasis;novel;Outcome;Ovarian;patient subsets;Patients;Pattern;Peptide Hydrolases;Population;population based;Population Study;Predictive Value;Primary Care Physician;programs;Promoter Regions;prospective;Prostate;prostate biopsy;prostate cancer risk;Prostate Cancer therapy;Prostate specific antigen measurement;Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial;Prostate-Specific Antigen;Prostatic;Proteins;PSA level;PSA screening;Publishing;Race;randomized trial;Recommendation;Research;Research Personnel;Risk;Risk Marker;risk prediction;risk prediction model;risk stratification;Role;Sampling;screening;Screening for Ovarian Cancer;Screening for Prostate Cancer;Single Nucleotide Polymorphism;Specific qualifier value;Specificity;Staging;Statistical Models;Technology;Test Result;Testing;Time;tool;treatment trial;United Kingdom;United States;Urology;Variant

PROJECT_TITLE: Influence of intra-individual variability in serial screening samples on clinical decision-making for risk stratification and biopsy by a single PSA and additional markers


PI_NAMEs: SALMON, ADAM  (contact)

PROJECT_TERMS: Acarbose;Address;Affect;Age;age effect;age related changes;Age related pathologies;age-related disease;aged;Aging;aging process;aging related;aging related disease;American;Award;Biology of Aging;Brain;Callithrix;Callithrix jacchus jacchus;Capsicum;cardiac aging;cardiovascular health;Cardiovascular system;Clinical Research;Collaborations;Collagen;comparative;cost;Country;Deposition;Development;Educational workshop;Elastin;Estradiol;executive function;Foundations;FRAP1 gene;Funding;Geroscience;Geroscientist;Grant;gut microbiome;healthspan;healthy aging;Heart;Human;immune function;improved;innovation;interest;Intervention;Kidney;Knowledge;Life Extension;life span;lipidome;lipidomics;Lipids;Liver;Magnetic Resonance Imaging;Measurement;meetings;Metformin;microbiome;Mission;Modeling;Myocardial dysfunction;National Institute of Dental and Craniofacial Research;nonhuman primate;novel;older adult;Pathology;Persons;Pharmacologic Substance;Pharmacology;Phase;Phenotype;Plasma;Play;pre-clinical;Pre-Clinical Model;pre-clinical research;Primates;programs;prospective;Research;research data dissemination;Research Design;Research Personnel;Research Support;Research Training;Resources;Rodent;Role;Sampling;Scientist;Services;Shock;Signal Pathway;Sirolimus;skills;social;Source;success;symposium;Technology;Testing;Tissue Banks;Tissue Sample;Tissues;Training;Translating;translational model;Translations;United States National Institutes of Health;Writing

PROJECT_TITLE: RC1: Pre-Clinical Research Core


ORG_CITY: SPRINGFIELD

ORG_NAME: ILLINOIS STATE EMERGENCY MANAGEMENT AGENCY

PHR: PROJECT NARRATIVE (Overall) To protect the public health during a nuclear or radiological event the FDA provides protective action guidance for food and animal feeds to limit radiation dose from consumption (FDA 1998) If an event releasing alpha and/or beta emitting major dose contributing nuclide(s) happens, a high load of food samples will need to be screened for the alpha and/or beta emitters to assist official with making decision to protective public health (Cunningham 2014). For this purpose, the Illinois Emergency Management Agency seeks to develop its capacity and capability in screening of alpha and beta emitters in foods.

PI_NAMEs: HOKE, KATELYN JEAN STEWART (contact)

PROGRAM_OFFICER_NAME: LI, MEI-YING

PROJECT_TITLE: Radiochemistry Capacity/Capability Development Expansion of Alpha or Beta Radionuclide Testing Capabilities


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: Project Narrative This project will develop new 30-MHz, high-frequency ultrasound, plane-wave CMUT row-column instrumenta- tion and signal-processing techniques to determine subtle changes in complex intracardiac blood ﬂow patterns in mouse models of cardiovascular disease. Progressive changes to ﬂow characteristics in transverse aortic con- striction mouse models of cardiomyopathy will be analyzed for ﬂow disruption prior to and during the development of left ventricle hypertrophy or dilatation and heart failure.

PI_NAMEs: FISHMAN, GLENN I;KETTERLING, JEFFREY  (contact);ORALKAN, OMER

PROGRAM_OFFICER_NAME: DANTHI, NARASIMHAN

PROJECT_TERMS: 3-Dimensional;aggressive therapy;animal imaging;Animals;aorta constriction;Blood flow;burden of illness;Cardiac;Cardiomyopathies;Cardiovascular Diseases;Cardiovascular Physiology;Cause of Death;Cessation of life;Characteristics;Complex;Data;design;Developed Countries;Development;Diagnosis;diagnostic tool;Dilatation - action;Discrimination;Disease;disease model;Early Diagnosis;Early identification;Elements;Failure;Frequencies;Goals;Hand;Heart;Heart failure;heart imaging;hemodynamics;high risk;Human;Hypertrophy;Image;imaging approach;Imaging Device;Imaging Techniques;in vivo;instrumentation;Left Ventricular Dysfunction;Left ventricular structure;Life Expectancy;Measures;Mechanics;Methods;millisecond;Modality;model organism;Modeling;Morbidity - disease rate;mouse model;Mouse Strains;Mus;Myocardial;Myocardial dysfunction;novel;operation;Pathogenesis;Pathologic;Patients;Pattern;Performance;Phenotype;Physiology;pre-clinical;preclinical imaging;pressure;response;Scanning;serial imaging;Signal Transduction;Speed;Stress;System;targeted treatment;Techniques;temporal measurement;Testing;Text;Three-Dimensional Imaging;Time;tool;Traction;Translating;Ultrasonography;ultrasound;vector;ventricular hypertrophy

PROJECT_TITLE: Murine cardiac vector-flow imaging with high-frequency 2D row-column CMUT arrays

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]


NIH_SPENDING_CATS: Aging;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Patient Safety;Physical Activity;Prevention;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

PI_NAMEs: ESPINOZA, SARA ELYSE (contact)

PROJECT_TERMS: Adipose tissue;Affect;Age;age effect;age-related disease;aged;Aging;aging process;aging related;aging related disease;alanine aminopeptidase;American;Award;Basic Science;Biological Markers;Biology of Aging;Biopsy;Callithrix;Capsicum;cardiac aging;Cardiovascular system;career development;Cells;circulating biomarkers;Clinical;Clinical Pharmacology;Clinical Research;Clinical Trials;Clinical Trials Data Monitoring Committees;Collaborations;Collagen;Collection;Communities;community advisory board;comparative;Data;data management;Deposition;design;Development;diabetes prevention program;Drug Kinetics;Drug toxicity;education research;Elastin;Ensure;Ethics;Evaluation;Faculty;frailty;FRAP1 gene;functional outcomes;Funding;Geriatrics;Geroscience;Goals;Good Clinical Practice;Grant;Health Promotion;healthspan;Human;improved;Informatics;Infrastructure;innovation;Intervention;K-Series Research Career Programs;Knowledge;Laboratories;lipidome;lipidomics;Lipids;Local Anesthetics;Magnetic Resonance Imaging;Measurement;Measures;medication safety;member;Metformin;Mission;Molecular;Monitor;Multicenter Trials;Muscle;Myocardial dysfunction;novel;older adult;Outcome Study;Oxytocin;Participant;Patients;Peripheral;Pharmaceutical Preparations;Pharmacodynamics;pharmacokinetics and pharmacodynamics;pharmacologic;Pharmacology;Phase;phase 2 study;phase I trial;Physical activity;Plasma;Play;practice-based research network;pre-clinical research;Prevention;Procedures;process improvement;programs;recruit;Registries;repository;Research;Research Design;Research Personnel;Rodent;Role;Safety;safety assessment;Sampling;senescence;senolytics;Services;Signal Pathway;single-cell RNA sequencing;Sirolimus;skills;stem cells;Technology;Testing;therapy design;Tissue Banks;Tissue Sample;Toxic effect;Training Support;Transducers;Translating;Translations;trial design;United States National Institutes of Health;Urine;Work

PROJECT_TITLE: RC2: Clinical Research Core


ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE The University of Pennsylvania Telehealth Research Center in Cancer Care (Penn TRC) will apply insights from communication science and behavioral economics to design and test synchronous telehealth strategies, supported by asynchronous elements, to improve effectiveness and equity across the cancer care continuum, with an emphasis on understanding mechanisms of action. We focus on lung cancer as an exemplar model for telehealth across the care continuum, from screening to treatment to survivorship. The Penn TRC will produce new fundamental knowledge with the potential to transform cancer care delivery, equity, and outcomes for millions of Americans.

PI_NAMEs: RENDLE, KATHARINE A. (contact);VACHANI, ANIL

PROGRAM_OFFICER_NAME: JENSEN, ROXANNE ELAINE

PROJECT_TERMS: Advanced Malignant Neoplasm;American;Area;asynchronous communication;Award;behavioral economics;cancer care;cancer health disparity;care delivery;Clinical;clinical practice;Communication;Communication Methods;compare effectiveness;Continuity of Patient Care;COVID-19 pandemic;design;digital divide;Discipline;Doctor of Philosophy;Effectiveness;effectiveness testing;Elements;Environment;Equity;evidence base;Faculty;FarGo;Fostering;Foundations;Future;Goals;Grant;Growth;Health;health care delivery;health communication;health equity;Healthcare;Improve Access;improved;Individual;innovation;insight;International;Intervention;Knowledge;Learning;lung cancer screening;Malignant neoplasm of lung;Measures;Methods;Mind;Modeling;Molecular;next generation;novel;Nurses;Outcome;Palliative Care;Patients;Pennsylvania;Pilot Projects;pragmatic trial;Public Health;randomized, clinical trials;Recommendation;Research;Research Methodology;Research Personnel;Resources;Science;screening;Secure;Sequential Multiple Assignment Randomized Trial;shared decision making;survivorship;symposium;telehealth;Telephone;Testing;Text Messaging;Time;tool;Training;trial design;Universities;waiver;Work

PROJECT_TITLE: Advancing cancer care and equity through telehealth, communication science, and behavioral economics


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Disorders;Mental Health;Mental Illness;Neurosciences

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

PHR: PROJECT NARRATIVE The overarching goal of this proposal is to develop new tools for integrative analysis of relationships among brain imaging measures. Despite the rise of multi-modal imaging studies and the proliferation of derived measures available from each modality, very little work has explored relationships between modalities. The methods developed as part of this proposal will fill this critical gap in the field, and yield biomarkers of both healthy brain development and abnormalities related to executive dysfunction in youth.

PI_NAMEs: SATTERTHWAITE, THEODORE ;SHINOHARA, RUSSELL TAKESHI (contact)

PROGRAM_OFFICER_NAME: BENNETT, YVONNE MARIE

PROJECT_TERMS: Acceleration;Address;Atlases;Attention;Biological Markers;Brain;Brain imaging;Brain Mapping;cohort;Complex;connectome;Coupling;Data;data resource;Data Scientist;demographics;Development;Diagnostic;Executive Dysfunction;Gene set enrichment analysis;Genomics;Goals;high dimensionality;Human;Image;imaging modality;imaging study;improved;Individual;innovation;insight;interest;Left;Link;Machine Learning;Measurement;Measures;Mental disorders;Methodology;Methods;Modality;Modeling;Multimodal Imaging;neuroimaging;Non-linear Models;novel;outcome prediction;Persons;Phenotype;Philadelphia;Procedures;Proliferating;Psychopathology;Regional Anatomy;Reproducibility;Research Personnel;Sampling;Science;Statistical Data Interpretation;Statistical Methods;statistics;Structure;success;Testing;tool;Work;Youth

PROJECT_TITLE: Inter-modal Coupling Image Analytics

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: DURHAM

ORG_DEPT: GENETICS

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Dietary diversity can reflect nutritional adequacy and health. However, surveys of dietary diversity are challenging to standardize and fill out accurately. Here, we will develop and test an objective biomarker that can track the diversity of plant and animal species that individuals consume.

PI_NAMEs: DAVID, LAWRENCE ANTHONY (contact)

PROGRAM_OFFICER_NAME: MARUVADA, PADMA

PROJECT_TERMS: African American;African ancestry;Age;Animals;Benchmarking;Biochemical;Biodiversity;Biological Markers;Biometry;Cardiometabolic Disease;Clinical;cohort;Communication;Complex;Consumption;Country;Data;Development;Diet;Diet Habits;Diet Research;Diet Surveys;dietary;Dietary Assessment;Dietary intake;Dietary Practices;Digestion;disorder risk;DNA;DNA Sequence;DNA sequencing;Eating;economic determinant;Education;Enrollment;Ethnic Origin;experimental study;Feces;feeding;Food;genomic biomarker;Genomics;Geography;Goals;Health;High-Throughput DNA Sequencing;Hispanic;Human;improved;indexing;Individual;insight;Intake;Link;Longitudinal cohort;Low income;lower income families;Measures;Metabolic Diseases;Minority Groups;Modeling;Monitor;Nature;Nutritional;nutritional epidemiology;obesity treatment;Organism;Outcome;Participant;Patient Self-Report;Physical activity;Plants;Population;Predisposition;Process;Protocols documentation;Public Health;Reaction Time;repository;Sampling;socioeconomics;specific biomarkers;Standardization;stool sample;Surveys;Sustainable Development;Systematic Bias;Techniques;Testing;Time;Time trend;United Nations;Wild Animals;Work;Youth

PROJECT_TITLE: Using DNA sequencing to assess dietary species richness

STUDY_SECTION: KNOD

STUDY_SECTION_NAME: Kidney, Nutrition, Obesity and Diabetes Study Section[KNOD]


NIH_SPENDING_CATS: Aging;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

PI_NAMEs: GELFOND, JONATHAN ADAM LETTERMAN (contact)

PROJECT_TERMS: age related;Aging;aging related;American;Automation;Biological Markers;biomarker performance;Biometry;Capsicum;clinical data warehouse;Clinical Informatics;clinical predictors;Clinical Research;Clinical Trials;Clinical Trials Database;Clinical Trials Design;cohort;Collaborations;Collection;Communities;Data;Data Analyses;Data Collection;data integration;data quality;data sharing;Databases;design;Development;Education;Electronic Health Record;Eligibility Determination;Enrollment;Ensure;experience;Faculty;faculty support;Feedback;Funding;Geroscience;Goals;Health Sciences;HRK gene;improved;Informatics;informatics tool;Information Dissemination;Information Services;Information Systems;Information Technology;Infrastructure;innovation;insight;interest;Lead;machine learning method;Medical Informatics;member;Mentors;Meta-Analysis;Methodology;Multicenter Trials;novel;Participant;Phase I Clinical Trials;Phenotype;Population;population health;power analysis;pre-clinical;prediction algorithm;primary endpoint;Production;Productivity;programs;protocol development;Publishing;Randomized;Reporting;Research;Research Design;Research Personnel;Research Project Grants;Resources;response;response biomarker;Sample Size;Sampling;Scheme;Services;System;Testing;Therapeutic;Training;Training and Education;translational therapeutics;trial design;web site;web-accessible

PROJECT_TITLE: RC3: Study Design and Integrative Informatics Coe


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome

PI_NAMEs: MACOSKA, JILL A. (contact)

PROJECT_TERMS: Address;African American;African ancestry;Androgen Receptor;anti-cancer research;Bioinformatics;Biomedical Research;Biostatistical Methods;Boston;BRCA2 gene;Cancer Biology;Cancer Center;cancer health disparity;cancer initiation;cancer risk;CHD1 gene;Code;cost;Dana-Farber Cancer Institute;Data;Data Analyses;design;DNA Sequence;Education;education research;Educational workshop;experience;Fees;Frequencies;Genetic Transcription;Genomic approach;genomic data;Genomics;Goals;health disparity populations;Infrastructure;innovation;Institution;Instruction;instrumentation;Learning;Malignant neoplasm of prostate;Massachusetts;men;Minority-Serving Institution;Modeling;nano-string;novel;Outcome;outreach;personalized cancer therapy;Population;programs;Prostatic Neoplasms;Quantitative Reverse Transcriptase PCR;Receptor Signaling;Research;Research Design;Research Personnel;Resources;Risk;RNA;single cell sequencing;SNP genotyping;Structure;Students;Technology;therapy resistant;tool;Training;tumor progression;Underrepresented Populations;Underrepresented Students;Universities;Untranslated RNA

PROJECT_TITLE: Genomics Core


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Bioengineering;Clinical Research;Emerging Infectious Diseases;Hematology;Infectious Diseases;Sepsis

ORG_CITY: Boxborough

ORG_NAME: HELIXBIND, INC.

PHR: PROJECT NARRATIVE Sepsis, the body’s response to a bloodstream infection, is often life-threatening. Timely administration of appropriate antimicrobials is critical for successfully patient outcomes. However, current diagnostics for identifying and characterizing the infection, necessary for selection of the appropriate antimicrobial, rely on blood culture and require several days to provide results. As a consequence, physicians have to rely on empirical treatment with broad spectrum antibiotics, which may be ineffective to the patient’s infection, exposes patients to the risk of complications, and exemplifies poor antibiotic stewardship. The efforts described in this proposed Phase II program will advance the maturity of a novel, fully automated test capable of characterizing clinically important resistance mechanisms in bloodstream infections in only a few hours and without cultures. Success in this effort will result in a diagnostic device addressing a significant unmet need, ready for transfer to manufacturing and verification & validation for FDA clearance and market launch.

PI_NAMEs: SINGER, ALON  (contact)

PROGRAM_OFFICER_NAME: RITCHIE, ALEC

PROJECT_TERMS: Address;Adopted;Antibiotic Resistance;Antibiotics;antimicrobial;Antimicrobial Resistance;assay development;Bacteremia;Biological Assay;Blinded;Blood;Blood specimen;Breakthrough device;Budgets;Caring;Cessation of life;Clinic;Clinical;Clinical assessments;Clinical Microbiology;Clinical Research;clinically relevant;commercialization;Communicable Diseases;Complement;Complex;cost;cross reactivity;design;Detection;Deterioration;Development;Diagnosis;Diagnostic;Diagnostic Equipment;diagnostic strategy;drug resistant microorganism;Engineering;Ensure;experience;Health system;Hospitalization;Hospitals;Hour;improved;Infection;instrument;instrumentation;Laboratories;Lead;Life;Manuals;manufacture;Marketing;Medical center;member;Methods;microbial;Molecular;mortality;Multi-Drug Resistance;novel;novel diagnostics;pathogen;pathogenic bacteria;pathogenic fungus;patient prognosis;Patient-Focused Outcomes;Patients;Performance;Phase;Physicians;Play;Preparation;Process;product development;programs;Reflex action;Research Design;Resistance;resistance gene;resistance mechanism;response;Risk;Role;Sampling;Sensitivity and Specificity;Sepsis;Septicemia;service utilization;Specific qualifier value;Specificity;Specimen;success;systemic inflammatory response;Technology;Temperature;Testing;Time;timeline;Translating;University Hospitals;verification and validation;Whole Blood;Work

PROJECT_TITLE: Direct detection and identification of antimicrobial resistance genes in bloodstream infections

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AIDC-V(13)]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Palliative Care;Social Determinants of Health;Telehealth

PI_NAMEs: BEKELMAN, JUSTIN  (contact)

PROJECT_TERMS: access disparities;Address;Advanced Malignant Neoplasm;advocacy organizations;behavioral economics;cancer care;Cancer Survivor;care delivery;career;career development;Caregivers;Caring;Clinical;clinical care;clinical practice;Collaborations;Communication;Communities;Continuity of Patient Care;Data Analyses;Data Collection;design;Development;Discipline;Disparity;Education;Effectiveness;Ensure;Environment;Equity;Evaluation;evidence base;experience;Faculty;Funding;graduate student;Guidelines;health care delivery;health care model;health disparity;health equity;Health Personnel;Healthcare;improved;Infrastructure;innovation;insight;Institutional Review Boards;Interdisciplinary Study;Intervention;Journals;Knowledge;Leadership;Licensing;Malignant Neoplasms;Manuscripts;Measures;Methodology;Mission;Monitor;National Cancer Institute;Outcome;Patient advocacy;patient oriented;Patients;Peer Review;Pennsylvania;Policies;Policy Maker;Positioning Attribute;Postdoctoral Fellow;pragmatic trial;Process;Professional Organizations;Publications;Quality of Care;Research;Research Methodology;Research Personnel;Resources;Science;Series;Service delivery model;success;Sum;symposium;synergism;Technology;telehealth;telehealthcare;Testing;Universities;Vision;visiting scholar


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Social Determinants of Health

PI_NAMEs: MUTCHLER, JAN  (contact)

PROJECT_TERMS: Absenteeism;Address;Advertising;analytical method;anti-cancer research;Articulation;Basic Science;Benchmarking;Boston;Cancer Center;cancer health disparity;Cancer Research Project;cardiovascular health;chemotherapy;Clinical Sciences;Collaborations;Communities;Consultations;Dana-Farber Cancer Institute;Data;data acquisition;Data Analyses;Data Collection;data management;design;Development;Discipline;Disease;Disparity;disparity reduction;Early Intervention;Education;education pathway;education research;Educational workshop;Ensure;Exercise;experience;Experimental Designs;Faculty;Fostering;Funding;Future;Generations;home test;Horns;improved;Incubators;Individual;Infrastructure;innovation;Institution;Intervention;Knowledge;Letters;Link;Logic;Malignant Neoplasms;Massachusetts;Measurable;Measurement;member;Mentorship;Methodology;Methods;Minority Groups;minority investigator;minority patient;minority trainee;Mission;Modeling;novel;obesity risk;outreach;Pattern;Persons;Pilot Projects;Population Analysis;Population Sciences;Postdoctoral Fellow;prevent;Process;Program Evaluation;programs;Qualifying;Recommendation;recruit;Research;Research Design;Research Methodology;Research Personnel;Research Project Grants;research study;Resource Sharing;Restaurants;Sampling;Sampling Biases;Selection Bias;Series;Services;sound;Statistical Methods;statistics;Students;success;synergism;Training;training opportunity;Underrepresented Minority;underrepresented minority student;underserved minority;Underserved Population;Universities

PROJECT_TITLE: Research Design and Analysis Core


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Lung Cancer;Palliative Care;Social Determinants of Health;Telehealth

PI_NAMEs: RENDLE, KATHARINE A. (contact)

PROJECT_TERMS: Address;Advanced Malignant Neoplasm;American;behavioral economics;cancer care;cancer risk;care delivery;Caring;clinical care;clinical practice;Communication;Communication Methods;compare effectiveness;Continuity of Patient Care;design;Development;digital;Disparity;Dissemination and Implementation;Effectiveness;Elements;Ensure;Equity;Evaluation;evidence base;Future;Goals;Health;health care delivery;health equity;Healthcare Systems;implementation framework;improved;Individual;Inequity;Information Dissemination;innovation;insight;Intervention;Investigation;Knowledge;lung cancer screening;Malignant neoplasm of lung;Measures;Methodology;Methods;Modeling;Monitor;Names;Nurses;Outcome;Patient Care;patient oriented;Patients;Pennsylvania;Pilot Projects;pragmatic trial;Process;programs;Recommendation;Research;Research Methodology;Research Personnel;Science;screening;Sequential Multiple Assignment Randomized Trial;Shapes;shared decision making;Statistical Methods;success;successful intervention;telehealth;telehealthcare;Telemedicine;Testing;therapy design;tool;trial design;Universities;Visit

PROJECT_TITLE: Research and Methods Core


PHR: WASHINGTON STATE FOOD SAFETY SURVEILLANCE PROJECT Narrative The WA State Food Safety Surveillance Project is a collaborative effort between the Microbiology and the Environmental Laboratory Sciences Departments of the WA State Public Health Laboratories. The project components proposed aim to enhance the established public health safety nets that are in place to ensure a safer Washington State food supply in future years.

PI_NAMEs: HIATT, BRIAN ;TAYLOR, BUD  (contact)

PROJECT_TITLE: Washington State Food Safety Surveillance Project


ORG_CITY: OKLAHOMA CITY

ORG_NAME: OKLAHOMA DEPT AGRICULTURE FOOD/ FORESTRY

ORG_STATE: OK

PHR: Funding Opportunity PAR-21-174 Oklahoma Department of Agriculture, Food, and Forestry  Project Narrative  The Oklahoma Department of Agriculture, Food, and Forestry will be able to reduce the potential threat to public health from ready-to-eat fruit and vegetables by developing, implementing and maintaining an Oklahoma Produce Safety Program that is in alignment with the FDA Regulation “Standards for the Growing, Harvesting, Packing and Holding of Produce for Human Consumption,” otherwise known as the Produce Safety Rule. This program will provide outreach to growers of ready-to-eat fruits and vegetables to educate and provide guidance concerning food safety issues associated with the growing of ready-to-eat produce and the regulatory requirements of the Produce Safety Rule. This combination of outreach and regulatory oversight should significantly reduce the risk of foodborne illness associated with the consumption of ready-to-eat produce.

PI_NAMEs: BUCHWALD, BRYAN ;MCCONAGHY, JUSTIN  (contact)

PROGRAM_OFFICER_NAME: VARGO, ADRIANNA

PROJECT_TITLE: Path C Oklahoma Department of Agriculture, Food, and Forestry Cooperative Agreement Program with FDA to Implement a National Produce Safety Program


NIH_SPENDING_CATS: Behavioral and Social Science;Biomedical Imaging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Lung Cancer;Palliative Care;Patient Safety;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Telehealth

PROJECT_TERMS: Address;Adult;Adult women;Advanced Malignant Neoplasm;Age;American;arm;Awareness;behavioral economics;Benefits and Risks;black patient;Black race;cancer care;cancer health disparity;cancer survival;care coordination;care delivery;Communication;comparative;compare effectiveness;Complex;contextual factors;COVID-19 pandemic;Data;Decision Aid;design;digital healthcare;Disparity;Effectiveness;effectiveness evaluation;Eligibility Determination;Equity;evidence base;Geography;Goals;Guidelines;health equity;Healthcare;Individual;Inferior;innovation;Insurance Coverage;Intervention;Interview;Knowledge;low dose computed tomography;lung cancer screening;male;Malignant neoplasm of lung;Methods;Modeling;mortality;Outcome;Patients;payment;Pennsylvania;Persons;Policy Maker;Population;pragmatic trial;preference;programs;Race;racial disparity;Radiation exposure;Randomized;Recommendation;Research;Risk;Science;screening;screening guidelines;Sequential Multiple Assignment Randomized Trial;sex;shared decision making;Smoking History;Socioeconomic Status;Surgical complication;telehealth;Testing;Time;Touch sensation;Training;trial design;Universities;uptake;Visit;women patients

PROJECT_TITLE: Pragmatic Trial


ORG_CITY: PHOENIX

ORG_NAME: ARIZONA STATE DEPARTMENT OF HLTH SRVCS

ORG_STATE: AZ

PHR: Arizona Department of Health Services Narrative for LFFM Grant – Project Narrative The ADHS is applying for the LFFM Grant and seeks to continue in food defense chemistry and expand whole genome sequencing capabilities. The ADHS seeks to engage in microbiology food defense, radio chemistry food defense, and chemistry food safety capabilities.

PI_NAMEs: WANGSNESS, KATHRYN  (contact)

PROJECT_TITLE: The Arizona Department of Health Services Food Safety and Food Defense Project


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Lung Cancer;Networking and Information Technology R&D (NITRD);Prevention;Primary Health Care;Social Determinants of Health;Telehealth

PI_NAMEs: VACHANI, ANIL  (contact)

PROJECT_TERMS: Advanced Malignant Neoplasm;Area;behavioral economics;Black race;cancer care;Cancer Center;Cancer Model;care delivery;Caring;Catchment Area;Clinical;clinical care;Clinical Informatics;clinical infrastructure;Clinical Oncology;clinical practice;clinical research site;Clinical Services;Communication;Communities;Community Health;connected care;Continuity of Patient Care;Country;County Hospitals;data infrastructure;Data Store;data warehouse;Department chair;digital;digital divide;Ecosystem;Effectiveness;effectiveness testing;electronic health record system;Ensure;Environment;Equity;Evaluation;evidence base;experience;Family Practice;Female;health disparity;Health Services Accessibility;Health system;Hospitals;Human Resources;implementation facilitation;improved;Informatics;informatics infrastructure;Infrastructure;Internal Medicine;Latinx;Leadership;Link;lung cancer screening;Malignant neoplasm of lung;Malignant Neoplasms;Medicaid;Medical center;Medicine;metropolitan;Modeling;Oncology;patient oriented;patient population;Patients;Pennsylvania;Philadelphia;Physician Executives;Physicians;Pilot Projects;pragmatic trial;Presbyterian Church;Primary Care;primary care services;Provider;Research;Research Methodology;Research Personnel;Resources;Science;screening;Screening for cancer;screening program;Services;Site;Structure;survivorship;System;telehealth;Testing;Uninsured;Universities;University Hospitals

PROJECT_TITLE: Clinical Practice Network


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Infectious Diseases;Prevention

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

PHR: PROJECT NARRATIVE Staphylococcus aureus causes corneal and intraocular infections that, despite current therapies, can result in significant loss of vision. This proposal investigates the pathogenic mechanisms by which Staphylococcus aureus initiates ocular infections, with the goal of identifying essential factors that can be targeted to prevent or treat infections and improve the visual outcome for patients afflicted with these infections.

PI_NAMEs: CALLEGAN, MICHELLE C (contact)

PROGRAM_OFFICER_NAME: GORDIYENKO, NATALIYA

PROJECT_TERMS: Acute;Address;Adherence;Adhesions;Affect;Agonist;Animals;Anti-Inflammatory Agents;Antibiotic Resistance;Antibiotics;Area;Attention;Bacteria;Bacterial Adhesins;Bacterial Eye Infections;Bacterial Infections;Binding;Biology;Blindness;Blood-Retinal Barrier;Bypass;Cell Culture Techniques;Cell Line;Cells;Communicable Diseases;Cornea;corneal epithelium;Data;design;Development;Disease;Endophthalmitis;Equation;Event;Experimental Designs;Eye;Eye Infections;Future;Genes;Genus staphylococcus;Goals;Growth;Health;Immune;Immune response;Immune system;Immunity;improved;In Vitro;in vivo;ineffective therapies;Infection;Infection prevention;Inflammation;Inflammatory;Inflammatory Response;innate immune pathways;innovation;Invaded;Keratitis;Knowledge;leukotoxin;Mediating;methicillin resistant Staphylococcus aureus;Modeling;Morbidity - disease rate;Multi-Drug Resistance;mutant;Organism;Pain;Pathogenesis;Pathogenicity;Pathway interactions;Patient-Focused Outcomes;Patients;Positioning Attribute;preservation;prevent;Prevention;Process;Production;programs;Publishing;Regulation;Research;Resistance;response;Retina;retinal damage;Risk;Speed;Staphylococcus aureus;Strategic Planning;Surface;Testing;Therapeutic;therapeutic development;therapeutic target;Time;Tissues;Toxin;Virulence;Virulence Factors;Vision;Visual

PROJECT_TITLE: Staphylococcus Biology in Ocular Infections

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurosciences;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Rehabilitation;Spinal Cord Injury;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation;Traumatic Head and Spine Injury

ORG_CITY: INDIANAPOLIS

ORG_DEPT: NEUROSURGERY

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

PHR: PROJECT NARRATIVE In this application, we propose to employ a novel strategy to convert endogenous reactive glial cells to new neurons (also called reprogramming) for functional recovery after spinal cord injury (SCI). We hypothesize that reprogramming reactive glial cells to local new neurons may promote self-repair by the formation of new neural circuits for functional recovery. To test this hypothesis, three specific aims are proposed to determine 1) the functional integration of reprogrammed neurons; 2) the anatomical integration of reprogrammed neurons into local neural circuitry; and 3) the functional roles of descending supraspinal and/or propriospinal pathways over reprogrammed neurons in promoting forelimb functional recovery in a model of cervical 5 dorsal hemisection (C5 DH).

PI_NAMEs: WU, WEI  (contact);ZHANG, CHUN-LI

PROGRAM_OFFICER_NAME: BAMBRICK, LINDA LOUISE

PROJECT_TERMS: Adopted;Adult;Anatomy;Astrocytes;Behavioral;Bilateral;Brain Injuries;Cell Therapy;Cell Transplantation;Cells;Cervical;Chondroitin Sulfate Proteoglycan;Chronic Phase;Cicatrix;Clinical;Complement 5a;Corticospinal Tracts;Dissection;Dorsal;endogenous stem cells;Exhibits;Failure;Forelimb;Functional impairment;functional improvement;Gene Modified;Genetic;Gliosis;Hand functions;Human;Impairment;improved;in vivo;Induced Neurons;Injury;innovation;Liver;Maps;Mediating;Modeling;Morbidity - disease rate;mortality;Motor;Mus;Natural regeneration;nerve injury;nerve stem cell;neural;neural circuit;Neuroglia;neuron loss;Neuronal Differentiation;Neurons;novel strategies;optogenetics;Organ;Paralysed;Pathway interactions;Patients;Phenotype;Play;postsynaptic;presynaptic;Productivity;programs;Proliferating;Quality of life;Recovery;Recovery of Function;Regenerative capacity;repaired;response;reticulospinal tract;Role;Sensory;Site;Skin;Somatic Cell;Spinal Cord;Spinal cord injury;Stem cell transplant;Structure of rubrospinal tract;Synapses;Synaptic Transmission;Techniques;Testing;Tissues;Transplantation;Virus

PROJECT_TITLE: Reprogramming reactive glial cells into functional new neurons after SCI


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: Angiogenesis is a dangerous and often visually devastating feature of many ocular pathologies, including corneal neovascularization, and pathologic angiogenesis also contributes to a variety of other diseases including cancer, heart disease, and arthritis. CMG2 inhibitors dramatically reduce pathologic angiogenesis in the cornea, but the role of CMG2 signaling in angiogenesis is not well understood. We recently discovered that CMG2 is required for endothelial cell chemotaxis, and here we propose to determine the mechanism by which CMG2 mediates the migration toward a growth factor source that is required for angiogenesis.

PI_NAMEs: ROGERS, MICHAEL SEAN (contact)

PROGRAM_OFFICER_NAME: MCKIE, GEORGE ANN

PROJECT_TERMS: Acceleration;Affect;angiogenesis;Angiogenesis Inhibitors;anthrax protective factor;ANTXR2 gene;Arthritis;Behavior;bevacizumab;Binding;Biological Assay;Blindness;Blood capillaries;Bypass;Cardiovascular Diseases;cell motility;Cell Polarity;Cell surface;Cell Surface Receptors;Cells;Cellular biology;cellular imaging;Chemotaxis;Chemotaxis Induction;Chemotaxis Inhibition;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;confocal imaging;Cornea;corneal epithelium;Corneal Neovascularization;Dangerousness;Data;Defect;design;Development;Diabetic Retinopathy;Disease;Drug Targeting;Endophthalmitis;Endothelial Cells;Exhibits;experimental study;extracellular;Extracellular Domain;Extracellular Matrix;Eye;FDA approved;FGF2 gene;Genes;Genetic;Graft Rejection;Growth Factor;Health;Heart Diseases;Human;in vivo;Individual;infection risk;inhibitor;Integral Membrane Protein;Integrins;Keratoplasty;Knock-out;Life;Ligands;Macular degeneration;Malignant Neoplasms;Mediating;Mediator;member;Meningitis;Methods;Microfluidics;migration;Migration Assay;Modeling;Morphogenesis;Motility;Movement;Mus;Mutagenesis;mutant;Mutation;Neovascular Glaucoma;novel;ocular neovascularization;Ocular Pathology;off-label use;Pain;Pathologic Neovascularization;Pathology;Pathway interactions;Patients;Peptides;Pharmaceutical Preparations;Pharmacodynamics;pharmacologic;Phenocopy;Physiologic Neovascularization;Platelet-Derived Growth Factor;Positioning Attribute;Process;Proteins;Proteomics;receptor;response;Retinopathy of Prematurity;rho;Risk;Role;side effect;Signal Pathway;Signal Transduction;small molecule;Solid;Source;Sphingosine-1-Phosphate Receptor;Tail;targeted treatment;Testing;Therapeutic;therapeutic target;Time;Travel;United States;Vascular Endothelial Growth Factors;vessel regression;Vision;Visual;Western Blotting;Work;wound

PROJECT_TITLE: Functional requirement of CMG2 for endothelial cell chemotaxis and resulting angiogenesis


NIH_SPENDING_CATS: Immunotherapy

ORG_CITY: PITTSBURGH

ORG_DEPT: DERMATOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PUBLIC HEALTH RELEVANCE Allergic contact dermatitis (ACD) is a substantial health problem that with a prevalence of 18% is the second highest cause of work-related diseases in the USA. There is an unmet need for more specific immunotherapies to treat ACD, which is caused by intricate interactions among neuro-mediators, skin resident cells, and migratory leukocytes. The present application proposes to investigate relevant mechanisms of these cellular and neuroimmune networks to provide fundamental physiopathologic insight for the development of specific immunotherapies for ACD.

PI_NAMEs: LARREGINA, ADRIANA T (contact);MORELLI, ADRIAN E.

PROGRAM_OFFICER_NAME: DONG, GANG

PROJECT_TERMS: adaptive immune response;Address;Affect;Affinity;Allergic Contact Dermatitis;Binding;CD8B1 gene;Cell Communication;Cells;Chronic Disease;chronic inflammatory skin;Collaborations;Cutaneous;cytokine;cytotoxic;Data;Dendritic Cells;Development;Dinitrochlorobenzene;Disease;effector T cell;Environment;Epithelial Cells;Exhibits;exosome;experimental study;Exposure to;extracellular vesicles;G Protein-Coupled Receptor Signaling;Generations;Haptens;Health;Human;Hypersensitivity;Immune response;Immunity;immunoregulation;Immunotherapy;Impairment;In Vitro;in vivo;Inflammasome;Inflammation;Inflammation Mediators;Inflammatory;Innate Immune Response;insight;intercellular communication;Interleukin-1 beta;keratinocyte;Leukocytes;Maintenance;Mediating;Mediator;Messenger RNA;microvesicles;Modeling;Molecular;mouse model;Mus;Neuroimmune;neuroinflammation;Neuropeptides;Nuclear Translocation;Pathogenesis;Pathogenicity;Pathway interactions;Pattern recognition receptor;Penetration;Peptide Signal Sequences;Peptides;Phenotype;Play;PPBP gene;Prevalence;Prevention therapy;Proteins;public health relevance;Publications;Publishing;receptor;Receptor Activation;receptor function;Receptor Signaling;response;Role;Signal Pathway;Signal Transduction;Site;Skin;skin disorder;Substance P;T cell response;T memory cell;T-Cell Activation;T-Lymphocyte;TACR1 gene;Testing;therapy development;vesicular release;Work

PROJECT_TITLE: Role of neurokinin 1 receptor signaling in keratinocytes in allergic contact dermatitis

STUDY_SECTION: ACTS

STUDY_SECTION_NAME: Arthritis, Connective Tissue and Skin Study Section[ACTS]


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE Vision impairment has devastating effects on human perception and quality of life. The major blinding diseases, such as age-related macular degeneration (AMD) and glaucoma, involve the permanent loss of retinal neurons. The proposed research will study neuroprotection mechanisms using advanced molecular and genetic approaches, and test new therapeutic strategies for retinal degeneration.

PI_NAMEs: YANG, XIAN-JIE  (contact)

PROGRAM_OFFICER_NAME: NEUHOLD, LISA

PROJECT_TERMS: Ablation;Acute;aerobic glycolysis;Age related macular degeneration;Anabolism;Animal Model;Aspartic Acid;Astrocytes;Biochemical;Biological Assay;Cell Nucleus;Cell Physiology;Cell Survival;cell type;Cells;Cellular Metabolic Process;Cellular Morphology;chemokine;Chronic;Ciliary Neurotrophic Factor;Clinical Trials;cytokine;cytokine receptor gp130;Cytokine Signaling;Data;density;Development;Disease;Dose;effective therapy;efficacious treatment;Enabling Factors;Endothelial Cells;Energy consumption;Energy Supply;Engineering;Enzymes;Event;Excision;Exposure to;Gene Deletion;genetic analysis;genetic approach;Genetic Transcription;Glaucoma;Hour;Human;Image;improved;inhibitor;insight;intravitreal injection;Investigation;Knowledge;Lactate Dehydrogenase;Maintenance;Mediating;Medicine;Metabolic;Metabolic Pathway;Metabolism;metabolomics;Microglia;mimetics;Mitochondria;Modeling;Molecular;Molecular Genetics;Morphology;mouse model;Muller's cell;Mus;mutant;Mutation;neuron loss;neuronal survival;Neurons;neuroprotection;Neuroprotective Agents;novel;novel therapeutic intervention;Nuclear;Outcome;Oxidation-Reduction;Perception;Persons;Phosphorylation;Photoreceptors;Play;preservation;prevent;Production;promote resilience;Proteins;Quality of life;rapid detection;Recombinant adeno-associated virus (rAAV);Recombinants;Research;response;Retina;Retinal Degeneration;Retinal Dystrophy;retinal neuron;retinal rods;Retinitis Pigmentosa;Rod;Role;Signal Induction;Signal Transduction;single-cell RNA sequencing;STAT3 gene;Stat3 protein;superresolution imaging;Testing;Tissues;transcriptome;transcriptome sequencing;transcriptomics;Treatment Factor;Viral;Viral Vector;Vision;Visual impairment;Work

PROJECT_TITLE: Metabolism and neuronal viability of the retina

STUDY_SECTION: BDE

STUDY_SECTION_NAME: Biology and Development of the Eye Study Section[BDE]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Biomedical Imaging;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Nutrition;Obesity;Osteoporosis;Prevention

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE In adults with obesity seeking treatment, weight loss should be composed almost exclusively of fat mass, but loss of lean mass and bone are unintentional consequences of weight loss, which has detrimental effects on health by mitigating improvements in insulin sensitivity, contributing to weight regain by reducing energy expenditure, and increasing the risk of frailty, falls, and fractures. Preclinical and early clinical data suggest that bimagrumab, an investigational new drug for obesity that inhibits the activin type II receptor (ActRII) inhibitor, may be anabolic to muscle and bone. We hypothesize that in a double-blind, placebo-controlled trial of 65 adults with obesity randomized to bimagrumab, semaglutide (which is FDA-approved for weight loss), or placebo, bimagrumab will result in metabolic improvements in muscle, visceral fat, and bone vs. semaglutide or placebo as an adjunct to a lifestyle intervention for weight loss over 52 weeks.

PI_NAMEs: HAINES, MELANIE SCHORR (contact)

PROGRAM_OFFICER_NAME: GOROSPE, RAFAEL

PROJECT_TERMS: Activins;Adipocytes;Adipose tissue;Adult;adult obesity;Agonist;Area;Body Composition;Body Weight decreased;bone;Bone Density;bone loss;bone mass;Bone Resorption;bone strength;cardiometabolic risk;Clinical Data;Cyclophosphamide;Diet;diet and exercise;Dose;double-blind placebo controlled trial;Double-blind trial;Dual-Energy X-Ray Absorptiometry;Energy Intake;Energy Metabolism;Failure;falls;Fatty acid glycerol esters;FDA approved;Finite Element Analysis;fluorodeoxyglucose positron emission tomography;Fracture;frailty;GDF8 gene;GLP-I receptor;Glucose Clamp;glucose disposal;glucose uptake;Goals;Health;hip bone;Hyperinsulinism;improved;Individual;inhibitor;Insulin;insulin sensitivity;Investigational Drugs;lifestyle intervention;Ligands;Magnetic Resonance Imaging;mechanical load;Mediating;Metabolic;mortality;Muscle;muscle form;Muscular Atrophy;Non-Insulin-Dependent Diabetes Mellitus;Obesity;obesity treatment;Operative Surgical Procedures;Osteoblasts;Osteogenesis;Osteoporosis;Pathway interactions;Pharmacotherapy;Placebos;pre-clinical;Pre-Clinical Model;preservation;Proliferating;Protein Biosynthesis;Randomized;Rest;Risk;Risk Factors;Rodent;sarcopenia;Serum;side effect;Skeletal Muscle;Thinness;Tissues;Translating;Type II Activin Receptors;Visceral;Visceral fat;Weight;weight loss intervention

PROJECT_TITLE: Effects of bimagrumab on body composition, insulin sensitivity, and bone in adults with obesity

STUDY_SECTION: HSDO

STUDY_SECTION_NAME: Human Studies of Diabetes and Obesity Study Section[HSDO]


NIH_SPENDING_CATS: Aging;Atherosclerosis;Cardiovascular;Nutrition;Obesity;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

PHR: PROJECT NARRATIVE Atherosclerosis is the leading cause of death worldwide and obesity is a major risk factor for the development of atherosclerosis and other metabolic diseases. My exciting data show that weight loss induced by caloric- restriction promotes resolution and remission of atherosclerosis and I propose to study the underlying mechanisms. My studies will uncover novel pathways responsible for the concomitant resolution of obesity and atherosclerosis.

PI_NAMEs: WEINSTOCK, ADA  (contact)

PROGRAM_OFFICER_NAME: CHEN, JUE

PROJECT_TERMS: Adipose tissue;Affect;Apoptosis;Arterial Fatty Streak;Arteries;Atherosclerosis;Blood Vessels;Body Weight decreased;bone;Bone Marrow;Caloric Restriction;Cardiovascular Diseases;Cardiovascular system;Cause of Death;Cell Physiology;Cells;Cholesterol;Chronic;Circulation;comorbidity;Data;Development;Diet;Disease;Disease Management;Disease remission;efficacious intervention;Emigrations;Epigenetic Process;Event;Foundations;Future;Genetic Transcription;Hematopoietic;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;Hematopoietic System;High Fat Diet;Human;hypercholesterolemia;Immune;Immunologics;Inflammation;Inflammatory;Kinetics;Macrophage;Mediating;Medical;Metabolic Diseases;Modification;Molecular;monocyte;Morbidity - disease rate;mortality;mouse model;Mus;novel;Obese Mice;Obesity;obesity development;Pathology;Pathway interactions;Phagocytosis;Phase;Phenotype;Population;Postdoctoral Fellow;Process;progenitor;programs;Proliferating;recruit;Research;Resolution;Risk Factors;Role;Signal Transduction;single-cell RNA sequencing;stem cell population;systemic inflammatory response;Testing;Time;tissue stem cells;Tissues;Transplantation;Work

PROJECT_TITLE: Mechanisms underlying caloric restriction-mediated resolution of atherosclerosis


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Aging;Brain Disorders;Climate-Related Exposures and Conditions;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Parkinson's Disease;Prevention;Social Determinants of Health

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

PHR: This project will leverage data on Medicare enrollees Parts A, B, and D, air pollution (PM2.5, NO2, and ozone), PM2.5 major components, weather variables, greenness, and multiple ZIP code level Census factors to estimate the link between individual and simultaneous exposure to air pollution, PM2.5 major components, weather and greenness and Parkinson’s Disease (PD) exacerbation of symptoms. We will develop and apply new and existing methods to characterize a complex set of possible effect modifiers and identify multiple risk and protective factors that determine vulnerability in PD, and develop open-source R packages, promoting full transparency and reproducibility of findings across different study populations. This project will provide the foundation to inform actionable policy to help slow the PD disease burden and improve the quality of life for millions of Americans.

PI_NAMEs: BRAUN, DANIELLE ;ZANOBETTI, ANTONELLA  (contact)

PROGRAM_OFFICER_NAME: GRAY, KIMBERLY A

PROJECT_TERMS: Acceleration;Acute;Admission activity;Adverse effects;Age;Air Pollution;American;burden of illness;Carbon Black;Caring;Censuses;Central Nervous System;Cessation of life;Chronic;Climate;climate change;Communities;comorbidity;Complex;Computer software;cooling centers;Data;Data Science;Disease;Disease Outcome;Economic Burden;Ensure;Environmental Exposure;Environmental Health;Environmental Risk Factor;Etiology;Exposure to;fine particles;Foundations;Genetic;Goals;Green space;high risk;hospital readmission;Hospitalization;hospitalization rates;human old age (65+);improved;Incidence;indexing;Individual;Inpatients;Intervention;Knowledge;Link;machine learning algorithm;machine learning method;Medical;Medicare;Medicare claim;Medicare Part A;Methods;Modeling;modifiable risk;Nervous System Disorder;neuroinflammation;Nitrates;Nitrogen Dioxide;novel;open source;Outcome;Outpatients;Oxidative Stress;Ozone;Parkinson Disease;Pathogenesis;Peer Review;Persons;Pharmaceutical Preparations;Policies;Population;Poverty;Predisposition;Prevention strategy;protective factors;Quality of life;Race;Reproducibility;Reproducibility of Results;Research;Research Personnel;response;Risk;Risk Factors;Role;Severities;Severity of illness;sex;Socioeconomic Status;spatiotemporal;Statistical Data Interpretation;Statistical Methods;study population;Subgroup;Sulfate;Symptoms;Temperature;urban planning;Visit;Weather;weather variables

PROJECT_TITLE: Characterizing the link between multiple environmental exposures and Parkinsons disease exacerbation

STUDY_SECTION: NAME

STUDY_SECTION_NAME: Neurological, Aging and Musculoskeletal Epidemiology Study Section[NAME]