ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Project Narrative Colorectal cancer (CRC) is the third most common and second deadliest cancer globally and has no effective treatment options for late-stage disease. Immunotherapies, such as anti-PD-1 therapy, target T cells to increase antitumor immunity and show a high response rate in a small subset of patients. This study aims to understand the non-coding RNA regulation of T cell biology in immunotherapy-responsive patients, and improve outcomes in treatment-resistant CRC.

PI_NAMEs: TANG, WILLIAM WEIHAO (contact)

PROGRAM_OFFICER_NAME: ODEH, HANA M

PROJECT_TERMS: adaptive immune response;Address;anti-PD1 therapy;anti-tumor immune response;CD3 Antigens;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Compartmentation;Cell Death;cell growth;Cells;Cellular biology;checkpoint inhibition;Clinical;Colon;Colon Adenocarcinoma;colon cancer patients;Colon Carcinoma;Colonic Neoplasms;Colorectal Cancer;cytotoxic CD8 T cells;Cytotoxic T-Lymphocytes;Data;Data Correlations;Data Set;Death Rate;Disease;DNA;effective therapy;Environment;Exclusion;Fibrosis;Frequencies;Gene Expression;Genes;Genetic Markers;genetic signature;Goals;Grant;Human;Immune;immune cell infiltrate;immune checkpoint blockade;Immune response;Immune Targeting;Immunity;Immunologic Markers;Immunophenotyping;Immunotherapy;improved;improved outcome;in vivo;Incidence;Infection;Inflammatory;innovation;Interferon Type II;Intrinsic factor;Malignant Neoplasms;Mediating;Melanoma;metastatic colorectal;MicroRNAs;Microsatellite Instability;Minority;Mismatch Repair Deficiency;Modeling;mouse model;Mus;neoantigens;new therapeutic target;Outcome;patient response;patient subsets;Patient-Focused Outcomes;Patients;PD-1 inhibitors;pembrolizumab;polarized cell;Production;Prognosis;Repression;Research;Resistance;response;screening;Solid Neoplasm;standard of care;Standardization;Survival Rate;T cell regulation;T-Lymphocyte;Testing;Th1 Cells;Th2 Cells;The Cancer Genome Atlas;Therapeutic;therapeutic target;tumor;Tumor Burden;tumor growth;Tumor Immunity;tumor microenvironment;Tumor Promotion;United States;Untranslated RNA;Work

PROJECT_TITLE: T cell expressed miR-155 promotes antitumor immunity and immune checkpoint blockade responses in colon cancer through repression of Ship1


ADMINISTERING_IC: DA

ARRA_FUNDED: N

ED_INST_TYPE: GRADUATE SCHOOLS

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Childhood Injury;Clinical Research;Drug Abuse (NIDA only);Mental Health;Mental Illness;Neurosciences;Pediatric;Physical Activity;Physical Injury - Accidents and Adverse Effects;Prevention;Social Determinants of Health;Substance Misuse;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: Boulder

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PSYCHOLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF COLORADO

ORG_STATE: CO

PHR: PROJECT NARRATIVE The ABCD Study consortium uses multimodal brain imaging, cognitive and clinical assessments, bioassays, mobile monitoring, and careful assessment of substance use, environment, psychopathological symptoms, and social functioning in 11,878 9-10 year-olds to be followed over 10 years, to determine the effects of substance use on adolescent brain and cognitive development. This ABCD Research Project Site will follow and assess participants enrolled in the study. These data will be shared with the scientific community to address a comprehensive range of questions concerning youth development.

PI_NAMEs: BANICH, MARIE T (contact);FRIEDMAN, NAOMI P.

PROGRAM_OFFICER_NAME: DEEDS, BETHANY

PROJECT_TERMS: 10 year old;Address;Adolescence;Adolescent;adolescent substance use;adverse outcome;Affect;Age;Alcohol consumption;Alcohols;Anxiety;assessment application;Athletic Injuries;Behavior;Bioinformatics;Biological Assay;Brain;Brain imaging;Caffeine;Calendar;Cannabis;Child;Childhood;Clinical assessments;Cognition;Cognitive;cognitive development;cognitive testing;cohort;college;Communities;Data;Data Analyses;Decision Making;design;Development;emerging adult;Emotional;emotional factor;Enrollment;Ensure;Environment;Environmental Exposure;Environmental Risk Factor;Epidemiology;Ethics;Event;experience;Feeling suicidal;Female;follow-up;Funding;gene interaction;Genetic;Impairment;Individual;Informatics;informatics infrastructure;Interview;Life;Link;marijuana use;Mental Depression;Mental disorders;Mental Health;Methodology;Methods;mobile application;mobile computing;Monitor;multimodality;neural;Neurocognition;Neurocognitive;neurodevelopment;neuroimaging;Neuropsychological Tests;novel;Occupations;Outcome;Parents;Participant;participant enrollment;participant retention;Persons;Physical activity;physical conditioning;Privatization;Process;Protocols documentation;Psychopathology;Qualifying;recruit;Registries;Research;research and development;Research Personnel;Research Project Grants;Resources;response;retention rate;Risk;Role;Sampling;Schools;Science;Secure;Severities;Siblings;Site;Sleep;Social Functioning;Social isolation;Specific qualifier value;Standardization;substance use;Symptoms;Teenagers;Telephone;temporal measurement;Text;Time;Tobacco;Tobacco use;Training;Traumatic Brain Injury;trend;Triplet Multiple Birth;tv watching;Twin Multiple Birth;Youth

PROJECT_TITLE: 14/21 ABCD-USA Consortium: Research Project Site at CU Boulder


ADMINISTERING_IC: DK

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Nutrition;Obesity;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PI_NAMEs: GALLAGHER, DYMPNA  (contact)

PROJECT_TERMS: Adipose tissue;Adult;Award;base;Behavioral;behavioral phenotyping;Biology;Body Composition;Body Weight;Brain imaging;Calories;Calorimetry;Child;Childhood;Clinical Research;Clinical Trials;Complex;Consultations;Core Facility;cost;Detection;Disease;Eating Disorders;endophenotype;energy balance;Energy Intake;Energy Metabolism;Equipment;Etiology;Exercise;experimental study;Fatty acid glycerol esters;Feeding behaviors;Funding;Generations;Genetic;Grant;Human;human subject;Image;in vivo;Individual;Infant;Instruction;interest;Laboratories;lifestyle intervention;Measurement;Measures;Medical;member;Metabolic;Methodology;Methods;Molecular;Multicenter Trials;New York;Non-Insulin-Dependent Diabetes Mellitus;Obesity;Pathogenesis;Peer Review;Periodicals;Phenotype;Physiological;Physiology;Population;Postdoctoral Fellow;Productivity;prophylactic;Publications;Regulation;Research;Research Personnel;Resources;Scientist;Services;sleep physiology;Structure;Students;Techniques;Technology;Testing;Therapeutic Intervention;Time;tool;Training;translational study;United States National Institutes of Health;Visit

PROJECT_TITLE: Human phenotype (Core A)


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

ORG_CITY: COLUMBIA

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

ORG_STATE: SC

PHR: Project 4 The goal of Project 4 is to improve our ability to diagnose, treat, and predict recovery from aphasia using quantitative and theoretical models of how language works and how it is implemented in the brain. Project 4 is highly collaborative in nature as it relies on data from Projects 1 and 2 and repeats some analyses from Project 3 but with a different analysis approach.

PI_NAMEs: HICKOK, GREGORY  (contact)

PROJECT_TERMS: Acquired Language Disorders;Agrammatism;Anatomic Models;angular gyrus;Anterior;Aphasia;aphasia recovery;Assessment tool;Bite;Brain;Clinic;clinical application;Clinical Research;Clinical Trials;clinically relevant;Code;Communication;Competence;Comprehension;Data;data integration;Data Set;Development;Diagnosis;Diagnostic Specificity;Disease;Evaluation;Functional disorder;Goals;Grant;Impairment;improved;Individual;Language;lexical;Linguistics;Maps;Measurement;Measures;Modeling;Motor;motor control;Names;Nature;neural;neural model;neural network;next generation;North America;Outcome;Outcome Measure;Paint;Patients;Persons;phonology;Play;predictive modeling;Predisposition;Probability;Process;Production;Prognosis;Psycholinguistics;Public Health;Publishing;Quality of life;Recovery;Resolution;response;Semantics;Speech;Structure of middle temporal gyrus;success;Superior temporal gyrus;syntax;targeted treatment;Taxes;Temporal Lobe;Testing;Theoretical model;theories;tool;Treatment outcome;Trees;Work

PROJECT_TITLE: Mapping the Neural Organization of Language from Words to Syntax


ADMINISTERING_IC: TR

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Rural Health;Social Determinants of Health;Telehealth

ORG_CITY: CHARLESTON

ORG_DEPT: PSYCHIATRY

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

PHR: PROJECT NARRATIVE The South Carolina Clinical and Translational Research Institute (SCTR)! has transformed the research environment across South Carolina by creating a Learning Health System characterized by strong training and infrastructure resources that stimulate collaboration and innovation as a means to accelerate the translation of biomedical research discoveries into human health improvements. A major focus of this application is to strengthen SCTR’s statewide collaborations through innovative partnerships and initiatives with an emphasis on rural and medically underserved communities where significant health disparities exist. We will develop, demonstrate and disseminate innovative ways to train a diverse workforce and address barriers to translational research, and we will continue to collaborate across the CTSA Consortium to maximize impact and improve the health of the nation. Page 278 Project Narrative

PI_NAMEs: BRADY, KATHLEEN T. (contact);FLUME, PATRICK A

PROGRAM_OFFICER_NAME: RADMAN, THOMAS C

PROJECT_TERMS: Abbreviations;Acceleration;Address;Advisory Committees;Advocacy;Affect;Architecture;Area;biomedical informatics;Biomedical Research;Caring;Clinical;clinical center;clinical data warehouse;Clinical Research;Clinical Trials;Collaborations;Communication;Communities;community engagement;County;cultural competence;Data;data warehouse;Development;digital health;Discipline;Dissemination and Implementation;Diverse Workforce;Educational Curriculum;Electronic Health Record;Electronics;Ensure;Entrepreneurship;Environment;experience;Fast Healthcare Interoperability Resources;flexibility;forging;Fostering;Geographic Locations;Goals;Government;Health;health disparity;Health Priorities;Health Sciences;Health system;Healthcare;Healthcare Systems;Heterogeneity;Historically Black Colleges and Universities;Home;Human;implementation research;improved;Individual;Informatics;Information Networks;innovation;innovative technologies;Institutional Review Boards;Interdisciplinary Study;Intervention;knowledge base;Learning;Medical;medically underserved;Medically Underserved Area;method development;Methodology;Methods;Mission;Modeling;novel;outreach;patient population;Peer Review;Policies;Policy Making;Population Heterogeneity;practice setting;Price;Process;programs;Public Health;Publications;Registries;Research;Research Institute;Research Personnel;Research Training;Resources;Rural;rural underserved;Scholars Program;Science;SCTR gene;Secure;Services;skills;social health determinants;social influence;South Carolina;Special Population;Structure;success;Support System;System;Technology;teleconsent;telehealth;Textiles;tool;Training;Training and Infrastructure;translational barrier;translational pipeline;Translational Research;Translations;underserved community;Universities;Vision;volunteer;Work;Workforce Development

PROJECT_TITLE: South Carolina Clinical & Translational Research Institute (SCTR)


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF PHARMACY

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurodegenerative;Neurosciences;Patient Safety;Social Determinants of Health

ORG_CITY: ANN ARBOR

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE Older adults with Alzheimer's disease and related dementias are more likely to be hospitalized and are at risk for medication and health problems after discharge, potentially worsened by new use of medications that affect cognition. This study will examine the effectiveness of two Medicare programs that provide medication reviews to reduce inappropriate medication use and adverse outcomes for older adults with dementia after hospitalization. This research will generate evidence to motivate health policy changes to improve the safe use of medications in older adults with dementia, a matter of national public health relevance and aligned with the mission of the National Institute on Aging (NIA).

PI_NAMEs: COE, ANTOINETTE BARTOLOTTA (contact)

PROGRAM_OFFICER_NAME: SALIVE, MARCEL

PROJECT_TERMS: acute care;Adverse drug event;Adverse effects;adverse outcome;Advisory Committees;Affect;Aftercare;Aging;Alzheimer's disease related dementia;American;Award;Behavioral Model;beneficiary;career development;Caregivers;Caring;Central Nervous System Agents;Clinical;Cognition;college;comorbidity;cost;Data;Delirium;Dementia;Development Plans;Doctor of Pharmacy;Doctor of Philosophy;Drug Interactions;Education;Effectiveness;effectiveness evaluation;effectiveness testing;Eligibility Determination;Emergency department visit;Ensure;Environment;Epidemiology;Exposure to;Female;Goals;Health;Health Policy;health service use;Health Services;Healthcare;hospital readmission;Hospitalization;hospitalization rates;Hospitals;Impaired cognition;improved;Income;indexing;Inpatients;K-Series Research Career Programs;Logistic Regressions;Low income;male;Managed Care;Measures;Medicare;Medicare Part B;member;Mentors;Mentorship;Methodology;Methods;Michigan;Mission;National Institute on Aging;Neurocognitive;older adult;Outcome;Patients;payment;Persons;Pharmaceutical Preparations;Pharmacists;Pharmacy facility;Physicians;Policies;poor health outcome;primary outcome;professor;programs;public health relevance;Public Policy;Quality of Care;racial minority;Research;Research Methodology;Research Personnel;Research Proposals;Resources;Risk;Risk Factors;Science;Scientist;secondary outcome;statistics;Testing;Training;Universities;Visit;Work

PROJECT_TITLE: Improving Medication Use and Outcomes in Older Adults with Dementia after Hospitalization: Effectiveness of Medicare Programs

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Behavior and Social Science of Aging Study Section[NIA-S]


NIH_SPENDING_CATS: Autoimmune Disease;Bioengineering;Biotechnology;Diabetes;Immunotherapy;Pediatric;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE The goal of this project is to develop, and test engineered immune cells that can be used to detect early onset type 1 diabetes and locally treat it, by suppressing destruction of islet cells. The approaches developed here should have significant impact on detecting, studying and treating a broad range of autoimmune disorders, including and beyond type I diabetes.

PI_NAMEs: LIM, WENDELL A (contact)

PROGRAM_OFFICER_NAME: BLONDEL, OLIVIER

PROJECT_TERMS: Adhesions;Antigens;Autoimmune Diseases;autoreactive T cell;Beta Cell;capsule;CD4 Positive T Lymphocytes;Cell Therapy;cell type;Cells;cellular engineering;cytokine;Cytoprotection;Cytotoxic T-Lymphocytes;design,build,test;Disease;Early Diagnosis;Engineering;Evaluation;flexibility;Gene Modified;Goals;Home;human pluripotent stem cell;IL2RA gene;Immune;immunoengineering;Immunosuppression;Immunotherapeutic agent;implantation;In Vitro;in vivo;Inflammatory;innovation;insulin dependent diabetes mellitus onset;Insulin-Dependent Diabetes Mellitus;Interleukin-10;islet;Islet Cell;islet stem cells;Kidney;Link;Malignant Neoplasms;Modeling;Mus;new technology;novel;novel strategies;Output;Pancreas;Patients;Production;protective factors;Proteins;receptor;Reporting;residence;response;sensor;Sentinel;synthetic construct;System;Testing;Therapeutic;Tissues;trafficking

PROJECT_TITLE: Engineering synthetic immune cells with modular sentinel and therapeutic functions for T1D


NIH_SPENDING_CATS: Genetics;Nutrition;Obesity;Prevention;Stem Cell Research;Stem Cell Research - Embryonic - Human

PI_NAMEs: SCHWARTZ, GARY J (contact)

PROJECT_TERMS: adipocyte differentiation;Adipocytes;Adipose tissue;Affect;animal resource;Animals;Autonomic Denervation;awake;base;Biology;Body Composition;Body Temperature;Body Weight;Bypass;Cell Separation;Characteristics;college;Complement;Continuous Glucose Monitor;cost;cost effective;Data;Dedications;Development;Diabetes Mellitus;Electromyography;energy balance;Energy Intake;Energy Metabolism;Equipment;equipment acquisition;Evaluation;experience;Fatty acid glycerol esters;Feeding behaviors;fluorescence microscope;Functional disorder;Funding;gastrointestinal;Gene Expression;Genetic;glucose metabolism;Grant;Histologic;Human;Immunologics;in vivo;indexing;Individual;Inflammation;insight;Journals;Laboratories;lipid metabolism;Liver;Macrophage;Magnetic Resonance Imaging;Maintenance;Manuscripts;Measurement;Measures;Medical center;Medicine;member;Metabolic;Metabolic Diseases;metabolic phenotype;Metabolism;microCT;Microscope;Mission;Molecular;Molecular Biology;Molecular Genetics;Morphology;mouse model;Mus;New York;nutrition;Obesity;Operative Surgical Procedures;Phenotype;Physical activity;Physiological;Physiology;prevent;Procedures;Process;Productivity;programs;protein metabolism;Publications;Rattus;Regulation;Research;Research Personnel;Resources;Rodent;Rodent Model;Running;Scientist;Services;Shivering;stem;System;Technical Expertise;Temperature;Thermogenesis;Thinness;Tissue Sample;Tissue Transplantation;Tissues;tool;United States National Institutes of Health;Universities;Variant;Weight;Weight Gain;Work

PROJECT_TITLE: Animal Phenotyping (Core B)


NIH_SPENDING_CATS: Aging;Aphasia;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Neurosciences;Rehabilitation;Stroke

PI_NAMEs: HILLIS, ARGYE E. (contact)

PROJECT_TERMS: Adherence;Adoption;Aphasia;aphasia recovery;aphasia rehabilitation;Attention;Behavioral;Blinded;California;Caregivers;Characteristics;Clinical;clinical diagnosis;Clinical Management;clinical research site;Clinical Trials;Cognitive Science;Collaborations;Collection;Communities;Data;Data Analyses;Data Collection;data management;design;Elements;Ensure;evidence base;experience;Feedback;Goals;Guidelines;Hospitals;Human Resources;Image;improved;Language;Life;Literature;Longitudinal Studies;Measures;Medical;member;Methods;Monitor;neuroimaging;Neurologist;Neurology;Outcome;Outcome Measure;Participant;participant retention;Pathologist;Patient Recruitments;patient retention;Performance;Phase;prevent;Procedures;Process Assessment;Protocols documentation;Qualifying;recruit;Research;Research Personnel;Sampling;Selection Bias;South Carolina;Speech;Speech-Language Pathology;spelling;Standardization;stem;Stroke;stroke rehabilitation;Testing;Training;Training Programs;treatment research;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Clinical Core


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Asthma;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Effects of Indoor Air Pollution;Immunotherapy;Lung;Microbiome;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: MADISON

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE Asthma disproportionately affects children in urban communities in the United States and imposes a great personal and health care burden. Despite treatment advances, a significant proportion of patients do not achieve disease control and continue to have high levels of morbidity and currently no intervention has proven to either prevent or cure this disease. By identifying and addressing these unmet needs in this application, we propose to improve current asthma care in urban children, pursue disease modification, and ultimately develop effective strategies to prevent asthma.

PI_NAMEs: GERN, JAMES E.;JACKSON, DANIEL J (contact)

PROGRAM_OFFICER_NAME: DONG, GANG

PROJECT_TERMS: 17 year old;Accident and Emergency department;Address;Affect;Air;airway immune response;Allergens;Allergic;Asthma;asthma exacerbation;Bacteria;Birth;Caring;Cells;Child;Childhood Asthma;Clinical Research;Clinical Trials;common treatment;Development;Dictyoptera;Dietary Intervention;Disease;Disease Progression;disorder control;disorder prevention;Double-Blind Method;double-blind placebo controlled trial;effective therapy;Emergency department visit;Enrollment;Environmental Risk Factor;Evaluation;Event;expectation;Exposure to;Extrinsic asthma;Family history of;Genetic Transcription;Goals;Guidelines;gut microbiome;healthcare burden;high risk;Hospitalization;Hospitals;Hypersensitivity;Immune;immunoregulation;Immunotherapy;improved;infancy;Infant;Infection prevention;Inflammation;insight;Intervention;Intervention Trial;Leadership;Life;longitudinal analysis;lower income families;Microbe;microbial;microbial colonization;microbiome;Modification;Molecular;Morbidity - disease rate;multiple omics;National Institute of Allergy and Infectious Disease;novel;novel strategies;Observational Study;omalizumab;Outpatients;Pathogenesis;Pathway interactions;Patients;Pattern;Phase;Phenotype;Placebo Control;Pollution;prevent;Prevention;programs;Protocols documentation;Recurrence;Research;Respiratory Disease;respiratory health;Respiratory Mucosa;Rhinitis;Risk;Risk Factors;Role;Self Care;Severities;Stress;subcutaneous;Supplementation;Testing;United States;urban children;Urban Community;urban setting;Vision;Wheezing

PROJECT_TITLE: Childhood Asthma in Urban Settings Clinical Research Network - Leadership Center


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Lung Cancer;Prevention;Social Determinants of Health;Substance Misuse;Telehealth;Tobacco;Tobacco Smoke and Health

ORG_CITY: OKLAHOMA CITY

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PHR: Narrative Lung cancer, primarily caused by cigarette smoking, is the leading cause of cancer death in the U.S., and lung cancer mortality is far higher among those of lower socioeconomic status than their higher SES counterparts. Offering small escalating financial incentives for smoking abstinence dramatically increases cessation rates among socioeconomically disadvantaged adults when incentives are included as an adjunct to clinic-based smoking cessation treatment. The primary purpose of the proposed project is to evaluate the efficacy and cost- effectiveness of an automated, smartphone-based approach to incentivizing smoking cessation, which is a critical step towards the widespread dissemination of CM treatment with the ultimate goal of reducing tobacco- related cancers and cancer disparities.

PI_NAMEs: KENDZOR, DARLA ELIZABETH (contact)

PROGRAM_OFFICER_NAME: CICCOLO, JOSEPH THOMAS

PROJECT_TERMS: Abstinence;Adult;Annual Reports;Biochemical;Cancer Etiology;cancer health disparity;Carbon Monoxide;Cellular Phone;Cessation of life;cigarette smoke;cigarette smoking;Clinic;comparative cost effectiveness;contingency management;cost;cost effective;cost effectiveness;Data;Development;Disease;Disparity;Economically Deprived Population;efficacy evaluation;Equipment;experience;facial recognition software;Family;Female;financial incentive;follow-up;Friends;Future;Goals;health disparity;Health Insurance;Health Services Accessibility;Healthcare;Healthcare Systems;Hospitals;Household;Incentives;Income;Individual;innovation;Internet;Intervention;Low income;low socioeconomic status;male;Malignant neoplasm of lung;Mediating;Medicaid;Monitor;mortality;Motivation;nicotine replacement;Office Visits;Outcome;Ownership;Participant;Patient Self-Report;payment;Persons;pharmacologic;Policies;Population;portability;Prevalence;primary outcome;Process;Psychological reinforcement;quitline;Randomized;Randomized, Controlled Trials;Recommendation;remote delivery;Research Personnel;Sampling;Schedule;Self Efficacy;Smoker;Smoking;smoking abstinence;smoking cessation;Smoking Cessation Intervention;smoking prevalence;Smoking treatment;socioeconomic disadvantage;Socioeconomic Status;standard care;Survival Rate;System;Technology;telephone coaching;Tobacco;Tobacco-Related Carcinoma;Travel;treatment group;Video Recording;Visit;Withholding Treatment;Work

PROJECT_TITLE: Mobile Contingency Management for Smoking Cessation among Socioeconomically Disadvantaged Adults

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;Infectious Diseases;Influenza;Lung;Pneumonia and Influenza

ORG_CITY: ROCHESTER

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: Respiratory viruses are an important cause of morbidity and mortality worldwide. The early innate immune response to viral infections needs to be finely tuned in order to generate just enough protective immunity, without causing too much inflammation and lung injury. In this proposal, we will investigate a new aspect of the early innate immune response to respiratory viruses, that we hope will shed some light on this balancing act of the immune system.

PI_NAMEs: GEORAS, STEVE N (contact)

PROJECT_TERMS: Actins;airway epithelium;airway inflammation;antagonist;antiviral immunity;Attenuated;CCR;Cells;chemokine;chemokine receptor;Chemotactic Factors;cofilin;Complex;conditional knockout;CXCL1 gene;cytokine;Cytokine Gene;Cytoskeleton;Double-Stranded RNA;Epithelial Cells;Epithelium;Functional disorder;Gene Expression;Genes;Genetic Transcription;helicase;IFIH1;Immune response;Immune system;Immunity;In Vitro;in vivo;Infection;Inflammation;Influenza;Influenza A virus;influenza infection;influenza pneumonia;Inhalation;inhibitor;Innate Immune Response;Interferons;interstitial;knock-down;Knockout Mice;Link;Lung;lung injury;MAP3K7 gene;Mediating;migration;Modeling;Morbidity - disease rate;mortality;Motility;Mus;Natural Immunity;neutrophil;Neutrophil Infiltration;NF-kappa B;novel;Pattern recognition receptor;Phosphorylation;Protein Dephosphorylation;Protein Isoforms;protein kinase D;Protein-Serine-Threonine Kinases;Pulmonary Inflammation;respiratory virus;Role;sensor;Signal Pathway;Signal Transduction;Signal Transduction Induction;Small Interfering RNA;TBK1 gene;Testing;Tight Junctions;TLR3 gene;transcription factor;Tretinoin;Viral;Virus;Virus Diseases;Virus Replication

PROJECT_TITLE: Novel role for protein kinase D in airway inflammation and antiviral immunity

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_DEPT: BIOCHEMISTRY

PHR: Project Narrative Many human diseases, from cancer to diabetes, can be caused by the misregulation of genes due to mutations in the DNA binding sites for key transcription factors. This project aims to understand at a high-resolution, mechanistic level, how transcription factors recognize these binding sites. Particular attention is paid to transcription factors that are members of large DNA binding families, such as homeodomain proteins, that have very similar DNA binding specificities on their own, yet carry out distinct functions in vivo.

PI_NAMEs: MANN, RICHARD S (contact)

PROGRAM_OFFICER_NAME: WELLS, MELISSA LYNN

PROJECT_TERMS: Animals;appendage;Attention;Binding Sites;Cells;Code;cofactor;Defect;Development;Diabetes Mellitus;DNA Binding;DNA Binding Domain;Embryonic Development;experimental study;Family;Funding;Genes;Genetic Transcription;Genomics;Goals;homeodomain;Homeodomain Proteins;HOX protein;human disease;In Vitro;in vivo;Invertebrates;Leg;Malignant Neoplasms;member;mutant;Mutation;novel;organ growth;Play;Post-Translational Protein Processing;programs;Proteins;Resolution;Role;Specific qualifier value;Specificity;transcription factor;Vertebrates;Visualization;whole genome;Wing

PROJECT_TITLE: Interpreting and Deploying Genomic Information During Animal Development

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Cerebrovascular;Congenital Structural Anomalies;Genetics;Neurosciences;Pediatric;Prevention;Stroke

ORG_CITY: HOUSTON

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: Project Narrative The brain arteriovenous malformation (bAVM) associated intracerebral hemorrhage (ICH) accounts for 25% of total hemorrhagic stroke in young patients and resulted in severe long-term disability and death. Currently, there is no non-invasive and safe therapy due to a lack of understanding of the ICH mechanism in bAVM. We will explore the role of microglia/macrophages in bAVM associated ICH and provide the preclinical efficacy of microglia/macrophages modulation to improve bAVM patient’s life quality.

PI_NAMEs: PARK, EUNSU  (contact)

PROGRAM_OFFICER_NAME: UTZ, URSULA

PROJECT_TERMS: 3-Dimensional;aged;Antibodies;Area;Arteries;Astrocytes;Blood;Blood - brain barrier anatomy;Blood Vessels;blood-brain barrier disruption;blood-brain barrier permeabilization;Brain;brain arteriovenous malformations;brain endothelial cell;Brain hemorrhage;brain parenchyma;Brain region;Cell Adhesion Molecules;Cell Communication;Cell Death;cell injury;Cells;Cerebral hemisphere hemorrhage;Cerebrovascular Disorders;Cessation of life;chemokine;Chronic;Clinical Research;clinically relevant;Coculture Techniques;conventional therapy;cytokine;Dichloromethylene Diphosphonate;Diphtheria Toxin;Endothelial Cells;Enzyme-Linked Immunosorbent Assay;experience;Functional disorder;Gelatinase A;genetic signature;Goals;Hemorrhage;high risk;Human;Immunohistochemistry;improved;Induced Mutation;Infiltration;Inflammaging;Inflammation;Inflammatory;Inflammatory Response;Injections;innovation;Intercellular Junctions;Interleukin-1 beta;Interleukin-6;intravital microscopy;Knockout Mice;Knowledge;KRAS2 gene;Lifelong disability;Liposomes;Literature;Long term disability;Macrophage;Measures;Mediating;Mediator;Messenger RNA;Microglia;Minocycline;Modeling;monocyte;Morbidity - disease rate;mortality;mouse model;multiplex assay;Mus;mutant;Mutation;Neurofibrillary Tangles;Neurologic Deficit;novel;old mice;Operative Surgical Procedures;Pathology;Pathway interactions;Patients;Peptide Hydrolases;pharmacologic;Phenotype;preclinical efficacy;preclinical study;prevent;Prevention;Prevention strategy;Process;Production;Proteins;Quality of life;recruit;release factor;Resected;Risk;Role;Rupture;Signal Transduction;Sorting;Tamoxifen;Testing;TNF gene;transcription factor;transcriptome sequencing;Vascular Endothelial Cell;Veins

PROJECT_TITLE: Microglia/macrophages as target to prevent intracerebral hemorrhage in KRAS mutation-induced brain arteriovenous malformations


NIH_SPENDING_CATS: Aging;Aphasia;Bioengineering;Biomedical Imaging;Brain Disorders;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Rehabilitation

PI_NAMEs: RORDEN, CHRISTOPHER  (contact)

PROJECT_TERMS: 3-Dimensional;Address;Affect;Age;aging brain;Algorithms;analytical tool;Anatomy;Aphasia;aphasia recovery;Archives;Behavioral;Brain;brain health;Brain imaging;Breeding;chronic stroke;Clinical;clinical imaging;clinical research site;Code;cohort;Communities;complex data;Computer Assisted;Computer software;Computer-Assisted Diagnosis;computerized data processing;Computing Methodologies;Data;data acquisition;Data Analyses;data format;data integration;Data Set;design;Detection;Development;Diagnosis;Digital Imaging and Communications in Medicine;Documentation;Educational workshop;empowerment;Ensure;Environment;Family;flexibility;Funding;Future;Genetic;graphical user interface;Human;Image;image processing;Imaging Device;imaging modality;Individual;Injury;innovation;interest;Label;large datasets;lectures;Lesion;Life;Location;machine learning method;Manuals;Maps;Methods;Mission;Modality;neuroimaging;Neurologic;Neurosciences Research;novel;open source;outreach;Participant;Pattern;Population;privacy protection;Process;Prognosis;Protocols documentation;Publishing;Quality Control;Research;Research Personnel;Research Project Grants;Scanning;Scientist;Secure;Seminal;Serotonin;Signal Transduction;Site;South Carolina;Stroke;Symptoms;Time;tool;Training;training data;United States National Institutes of Health;Universities;Visualization;Visualization software;wiki;Work;young adult

PROJECT_TITLE: Neuroimaging Core


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Eating Disorders;Mental Health;Mental Illness;Neurosciences;Nutrition;Obesity;Prevention

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Project Narrative Obesity is associated with increased risk for chronic diseases and mortality. Binge eating and binge eating disorder are characterized by self-regulation problems and are strongly related to excess weight; thus, binge eating represents an important modifiable behavior to target in obesity prevention and intervention efforts. The proposed project will use a multimethod approach to examine affect, attention bias towards food, and impulsivity in a sample of adults at risk for obesity, with the goal of elucidating how self-regulatory processes predict momentary binge eating and short-term weight change.

PI_NAMEs: SMITH, KATHRYN ELIZABETH (contact)

PROGRAM_OFFICER_NAME: CUMMINGS, DIANA M

PROJECT_TERMS: Adult;Affect;Affective;Area;Attention;attentional bias;Award;Behavioral;Binge Eating;Binge eating disorder;biobehavior;Body mass index;Body Weight Changes;Brain region;career;Chronic Disease;comorbidity;Consumption;Cues;Data Collection;Decision Making;design;Desire for food;discounting;discrete time;Disease;Distress;Eating;Eating Behavior;Eating Disorders;Ecological momentary assessment;Educational workshop;emotion dysregulation;Emotional;Equilibrium;executive function;experience;follow up assessment;follow-up;Food;Foundations;Functional Magnetic Resonance Imaging;Funding;Future;Goals;Health;Impairment;Impulsivity;incentive salience;indexing;Individual;Informal Social Control;interest;Interruption;Intervention;Interview;Knowledge;Laboratory Study;Lead;Life;Link;loss of control over eating;Measurement;Measures;Medial;Medical;meetings;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Methodology;Methods;Modeling;modifiable behavior;mortality;Motivation;negative affect;neural;neurobiological mechanism;Neurobiology;Neurocognitive;Neurologic;Neurosciences;novel;Obesity;Obesity Epidemic;obesity prevention;obesity risk;obesity treatment;Outcome;Overweight;Participant;Patient Self-Report;Persons;Play;Precision therapeutics;preference;Prefrontal Cortex;preventable death;Prevention;Process;programs;Protocols documentation;Psychopathology;Reporting;Research;Research Design;Research Personnel;response;Rewards;Risk;Role;Sampling;Self-control as a personality trait;skills;success;Symptoms;System;Task Performances;Time;Training;trait;Weight;Weight Gain

PROJECT_TITLE: Biobehavioral self-regulatory processes underlying real-time binge eating symptoms and obesity risk

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics;Human Genome;Neurosciences;Nutrition;Obesity;Stem Cell Research;Stem Cell Research - Embryonic - Human

PI_NAMEs: EGLI, DIETER MEINRAD (contact)

PROJECT_TERMS: analytical tool;Animal Model;Area;Basic Science;Bioinformatics;Biological;Biomedical Research;Brain;brain research;Cell Lineage;cell type;Cells;Clinical Research;Cloning;Collaborations;college;Communities;comorbidity;Consultations;Core Facility;cost;Coupling;CRISPR/Cas technology;Data;Data Analyses;Derivation procedure;design;designer receptors exclusively activated by designer drugs;Development;differentiation protocol;DNA;DNA sequencing;Emerging Technologies;Equipment;experience;experimental analysis;Experimental Designs;experimental study;Faculty;feeding;Fibroblasts;Fostering;Funding;Gene Expression;Generations;Genes;genetic manipulation;Genetic Techniques;genome editing;Genomics;Genotype;Goals;Grant;Human Resources;Hypothalamic structure;Imaging technology;induced pluripotent stem cell;induced pluripotent stem cell technology;Infrastructure;Institution;instrumentation;interest;investigator training;Laboratories;Leptin;leptin receptor;Libraries;Manuscripts;Maps;Mediation;Medical;Medical center;Medicine;member;Methods;model organism;Modernization;Molecular;Molecular Biology;Molecular Biology Techniques;Molecular Genetics;molecular imaging;Mus;Mutation;Neurons;Neurosciences;new technology;New York;novel;nutrition;Obesity;optogenetics;Pathogenesis;patient derived induced pluripotent stem cells;Peer Review;Phenotype;Phylogenetic Analysis;Physiological;Play;Preparation;Price;Process;Productivity;programs;Publications;Reagent;Recording of previous events;Research;Research Activity;research and development;Research Design;Research Personnel;Research Project Grants;Research Support;Resources;Ribosomal RNA;Role;Sampling;Services;single cell ATAC-seq;single cell sequencing;Site;skills;stem cells;Students;success;Techniques;Technology;Time;Tissues;tool;Training;transcriptome sequencing;Transgenic Mice;Universities;Viral;Visualization

PROJECT_TITLE: Molecular Biology/Molecular Genetics (Core C)


ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE – DIRECTORS OVERVIEW The O'Neal Comprehensive Cancer Center is committed to reducing the cancer burdens and cancer disparities in the State of Alabama. This is done through a basic science and population science strategic research plan that is developed with community engagement and focused on elucidating the risk factors and mechanistic underpinnings of these cancer burdens and cancer disparities. The results of this work are then translated through diagnostic and therapeutic clinical trials to impact cancer outcomes and behavioral interventions to mitigate cancer risks and improve the quality of life of cancer survivors in our catchment area.

PI_NAMEs: SLECKMAN, BARRY P (contact)

PROGRAM_OFFICER_NAME: HE, MIN

PROJECT_TERMS: Abbreviations;Achievement;Advisory Committees;Alabama;animal imaging;Area;Arkansas;Asian Americans;Award;Basic Science;Behavior Therapy;Bioinformatics;Biometry;Cancer Biology;Cancer Burden;cancer care;Cancer Center;Cancer Center Support Grant;Cancer Control;cancer health disparity;Cancer Hospital;cancer imaging;Cancer Patient;cancer prevention;cancer risk;Cancer Survivor;Cancer Survivorship;Caring;Catchment Area;Clinical;clinical center;Clinical Research;Clinical Sciences;clinical translation;Clinical Trials;Code;Collaborations;Colon Carcinoma;Communication;Communities;community advisory board;community engagement;Community Health;Community Outreach;Comprehensive Cancer Center;Country;County;COVID-19;Detection;Diagnostic;Direct Costs;Disease;Disparity;drug discovery;Education;Education and Outreach;equity, diversity, and inclusion;Exhibits;Flow Cytometry;Focus Groups;Funding;Genetic Engineering;Genomics;Gifts;Goals;Health Services Accessibility;Healthcare;Historically Black Colleges and Universities;human imaging;improved;Incidence;Industry;Infrastructure;Investigational Therapies;investigator-initiated trial;Lead;Life;Louisiana;Malignant Breast Neoplasm;Malignant neoplasm of brain;Malignant neoplasm of cervix uteri;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant Neoplasms;Measures;medically underserved;medically underserved population;member;Metabolism;microbiome;Microscopy;Minority;Minority Groups;Mission;Mississippi;Modeling;Monitor;mortality;multidisciplinary;Multiple Myeloma;Names;NCI-Designated Cancer Center;neuro-oncology;next generation;novel;novel strategies;Obesity;Outcome;Patient Recruitments;Patients;Persons;Population;Population Sciences;Prevention;Process;Productivity;programs;Proteomics;Protocols documentation;Publications;quality of life for cancer survivors;racial disparity;Research;Research Personnel;Resource Sharing;Risk Factors;Rural;rural counties;Rural Population;Schools;Science;screening;Services;single cell analysis;Strategic Planning;structural biology;survivorship;Therapeutic;Therapeutic Clinical Trial;Therapeutic Trials;Tissue Procurements;Transgenic Organisms;Translating;Translational Research;Translations;tumor immunology;Underserved Population;United States;Universities;Vision;Work;working group

PROJECT_TITLE: Comprehensive Cancer Center Support Grant

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Chronic Pain;Complementary and Integrative Health;Contraception/Reproduction;Digestive Diseases;Endometriosis;Neurosciences;Pain Research;Women's Health Research

ORG_CITY: PONCE

ORG_DEPT: PHYSIOLOGY

ORG_NAME: PONCE SCHOOL OF MEDICINE

ORG_STATE: PR

PHR: Endometriosis is a poorly understood painful condition that incapacitates and affects the productivity and well-being of millions of women around the world. Symptoms of this disease are considered significant sources of stress occurring throughout the reproductive life of these patients. This study will reveal novel therapeutic approaches for patients with endometriosis by creating a new area of investigation for better treatments that could improve women’s health.

PI_NAMEs: APPLEYARD, CAROLINE B (contact)

PROGRAM_OFFICER_NAME: FRINCU, CRINA

PROJECT_TERMS: Adhesions;Affect;Age;Agonist;Anatomy;Animal Model;Animals;Anti-Inflammatory Agents;Area;Astrocytes;Behavioral;behavioral response;Cells;Chronic;chronic pelvic pain;Clinical Management;Colitis;Colon;Complementary therapies;Complex;cytokine;daily functioning;Data;design;Development;Disease;economic cost;economic impact;Electrocardiogram;Endometrial;endometriosis;Enteral;Enteric Nervous System;Environment;environmental enrichment for laboratory animals;Exercise;Exposure to;Female Genital Diseases;Fibrosis;Functional disorder;gastrointestinal symptom;Genetic Transcription;Gland;glial cell-line derived neurotrophic factor;Glial Fibrillary Acidic Protein;Goals;graduate student;Gynecologic;Illness Days;Immune;immune activation;implantation;improved;Inflammation;Inflammatory;inflammatory modulation;inflammatory pain;Inflammatory Response;Institution;Insurance;Integrative Therapy;Interdisciplinary Study;interest;intervention effect;Intestinal Diseases;Intestines;Investigation;Irritable Bowel Syndrome;Lesion;Life;Ligands;Localized Lesion;Mediating;Medical Care Costs;nerve supply;Neuroglia;neurotrophic factor;new therapeutic target;NF-kappa B;Nonpharmacologic Therapy;novel;novel therapeutic intervention;Nutritional;Outcome;Ovarian Cysts;Oxidative Stress;Pain;Parasympathetic Nervous System;Pathway interactions;Patients;Pelvis;Peritoneal;Personal Satisfaction;Phenotype;PPAR gamma;Process;Productivity;Program Sustainability;programs;protein expression;Protocols documentation;reduce symptoms;reproductive;Research;Research Project Grants;Role;S-Nitrosoglutathione;Science;Severities;Source;Spinal;Stains;Stress;stress reduction;subfertility;Symptoms;training opportunity;Translating;Translational Research;undergraduate student;Uterine cavity;Vesicle;Woman;Women's Health;Work

PROJECT_TITLE: The Enteric Glia as a Possible Target for Symptom Relief in Endometriosis


ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: NARRATIVE Most of the 500,000 patients in this country on hemodialysis use an arteriovenous fistula (AVF) as their vascular access. These “lifelines”, however, have a 50% failure rate at 6 months due to an ingrowth of cells. Our goal is to understand more about this ingrowth so that we can save our patients’ “lifeline”.

PI_NAMEs: ROY-CHAUDHURY, PRABIR ;XI, GANG  (contact)

PROGRAM_OFFICER_NAME: GOSSETT, DANIEL ROBERT

PROJECT_TERMS: Address;Area;Arteriovenous fistula;Biology;Blood flow;Blood Vessels;Catheters;cell growth;Clinical;Coronary;Country;Dependence;Diabetes Mellitus;Dialysis procedure;Diameter;Dilatation - action;economic cost;Environmental Impact;experience;Experimental Models;Failure;Functional disorder;Future;General Population;Genetic;genetic manipulation;GKLF protein;Goals;Growth;Growth Factor;Hemodialysis;hemodynamics;Histologic;Hyperglycemia;Hyperplasia;In Vitro;in vivo;Infection;infection risk;inhibitor;innovation;Insulin;insulin receptor substrate 1 protein;Intervention;Knock-out;Limb structure;MDM2 gene;Mediating;Morbidity - disease rate;mortality;mouse model;Mus;novel;novel therapeutics;nutlin 3;overexpression;Pathway interactions;Patients;Peripheral Vascular Diseases;PF4 Gene;Phenotype;Play;Role;shear stress;Signal Transduction;Signal Transduction Pathway;Smooth Muscle Myocytes;Stenosis;TP53 gene;transcription factor;Ubiquitination;Uremia;Vascular Smooth Muscle;Venous

PROJECT_TITLE: Modulation of VSMC phenotype through the Insulin Receptor Substrate-1/Kruppel-like factor-4 signal transduction pathway: a Novel Target for AVF Dysfunction

STUDY_SECTION: KUFD

STUDY_SECTION_NAME: Kidney and Urological Systems Function and Dysfunction Study Section[KUFD]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Neurosciences;Substance Misuse

PHR: Project Narrative Repetitive alcohol use, escalated intake, and relapse are hallmark pathologies of alcohol use disorders (AUD). In this preclinical project, we are focused on evaluating TARP γ-8, a novel target in the brain that controls alcohol- seeking behavior. We are taking a multidisciplinary approach that involves genetic, behavioral, pharmacological, molecular, and physiological techniques to fully characterize TARP γ-8 regulation of alcohol use, escalated intake, and relapse in mouse behavioral models. Successful completion of the proposed studies has potential to lead to new therapeutic strategies for treating behavioral pathologies associated with AUD.

PI_NAMEs: HODGE, CLYDE W (contact)

PROGRAM_OFFICER_NAME: GRAKALIC, IVANA

PROJECT_TERMS: Abstinence;abuse liability;addiction;Address;Affect;Alcohol consumption;alcohol effect;alcohol reinforcement;alcohol seeking behavior;alcohol use disorder;Alcohols;AMPA Receptors;Amygdaloid structure;Behavior;Behavior Therapy;Behavioral;Behavioral Model;behavioral plasticity;Brain;brain control;Brain region;calmodulin-dependent protein kinase II;clinical practice;craving;Cues;Data;design;Development;drug of abuse;experimental study;Exposure to;Genetic;genetic regulatory protein;Genetic Techniques;Glutamates;inhibitor;innovation;insight;Intake;interdisciplinary approach;Knowledge;Link;Maintenance;Mediating;Membrane;Methods;Modeling;Molecular;multidisciplinary;Mus;neural;neuromechanism;novel;novel therapeutic intervention;Pathologic;Pathology;Pathway interactions;Pharmaceutical Preparations;pharmacologic;Pharmacology;Physiological;pre-clinical;preclinical study;problem drinker;Process;Property;Prosencephalon;protein expression;Protein Family;Proteins;Psychological reinforcement;public health relevance;receptor;receptor function;Regulation;Relapse;Rewards;Role;Self Administration;Site;Slice;Stimulus;Synaptic plasticity;System;Techniques;Testing;therapeutic target;trafficking;transmission process;Work

PROJECT_TITLE: Novel mechanism of alcohol self-administration and relapse

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


NIH_SPENDING_CATS: Cancer;Prevention

PI_NAMEs: BERTRAM, MICHAEL JAMES (contact)

PROJECT_TERMS: Abbreviations;Academic Medical Centers;Administrative Supplement;Alabama;anti-cancer research;Area;Automobile Driving;Back;Cancer Center;Cancer Center Support Grant;cancer prevention;Cancer Survivorship;Catchment Area;Clinical Research;Clinical Trials;Collaborations;Communication;Communities;community engagement;Community Outreach;Comprehensive Cancer Center;Consultations;Data;Decision Making;Dedications;Development;Direct Costs;Education and Outreach;Ensure;Environment;Evaluation;evidence base;experience;Family;federal policy;functional group;Fund Raising;Funding;Gifts;Goals;Guideline Adherence;Guidelines;Industry;infrastructure development;Institution;Interdisciplinary Study;Intervention;Investments;Knowledge;Leadership;Life;Malignant Neoplasms;medical schools;member;Mission;Modeling;Monitor;Names;NCI-Designated Cancer Center;next generation;novel;operation;Operations Research;Patients;Philanthropic Fund;Policies;Process;programs;Protocols documentation;Qualifying;Recording of previous events;recruit;Reporting;Research;Research Support;Resource Allocation;Resource Sharing;Resources;Review Committee;Role;Services;software systems;Specialist;Strategic Planning;success;System;Training;Training and Education;tumor;Universities;Vision

PROJECT_TITLE: Cancer Center Administration


NIH_SPENDING_CATS: Cancer;Rural Health;Social Determinants of Health

PI_NAMEs: SHEVDE, LALITA A. (contact)

PROJECT_TERMS: Abbreviations;acronyms;Address;Advisory Committees;Alabama;American Society of Clinical Oncology;anti-cancer research;Bachelor's Degree;Basic Science;Cancer Biology;cancer care;Cancer Center Support Grant;cancer education;cancer health disparity;cancer therapy;career;career development;Catchment Area;Clinical;clinical center;Clinical Investigator Award;Clinical Research;Clinical Sciences;Communities;community center;community engagement;Community Outreach;Comprehensive Cancer Center;Degree program;Development;Discipline;diversity and inclusion;Doctor of Medicine;Doctor of Philosophy;Education;education research;ethnic minority;Faculty;Fostering;graduate medical education;Grant;Growth;Health Disparities Research;Health Professional;Healthcare;high school;Historically Black Colleges and Universities;Household;improved;Individual;Infrastructure;inner city;Institution;Investigational Therapies;Investments;junior high school;Lead;Learning;Malignant Neoplasms;Medical;medical schools;Mentors;Mentorship;Minority;Minority Groups;Mission;Morehouse School of Medicine;multidisciplinary;National Clinical Trials Network;next generation;Oncology;Pathway interactions;Peer Review;Peer Review Grants;Physicians;Population;Population Sciences;Positioning Attribute;Postdoctoral Fellow;Preparation;Productivity;Program Reviews;programs;Race;racial diversity;racial minority;Research;Research Personnel;Research Training;Resource Sharing;Role;Rural;Rural Population;Schools;Science;Science, Technology, Engineering and Mathematics;Scientist;Site;Societies;socioeconomics;Structure;Students;success;Talents;teacher;tool;Training;Training Activity;Training and Education;training opportunity;Training Programs;Translational Research;undergraduate student;Underrepresented Minority;underrepresented minority student;Underrepresented Students;underserved students;Writing

PROJECT_TITLE: Cancer Research Training and Education Coordination


NIH_SPENDING_CATS: Clinical Research;Nutrition;Obesity;Stem Cell Research;Stem Cell Research - Embryonic - Human

PI_NAMEs: KORNER, JUDITH  (contact)

PROJECT_TERMS: Advisory Committees;Ally;Area;Award;Basic Science;Biological Sciences;Body Weight;Budgets;Cancer Center;career;Cellular biology;Clinical;Clinical Research;college;Diabetes Mellitus;Direct Costs;Educational process of instructing;Elements;Etiology;Faculty;Foundations;frontier;Funding;Grant;high risk;Individual;Industry;innovation;Institution;medical schools;Medicine;member;Mentors;Mentorship;Metabolic Diseases;Metabolism;mid-career faculty;Mission;Neurobiology;Neurosciences;New York;nutrition;Nutritional Science;Nutritional Study;Obesity;Oncology;Pathology;Peer Review;personalized medicine;Physicians;Process;professor;programs;recruit;Regulation;Research;Research Personnel;Research Project Grants;Resources;Students;Surgeon;Talents;Translational Research;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Pilot and Feasibility Program


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Immunotherapy;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

PI_NAMEs: SUDARSHAN, SUNIL  (contact)

PROJECT_TERMS: Abbreviations;Acarbose;Achievement;Acute Myelocytic Leukemia;Alabama;alpha ketoglutarate;animal imaging;anti-cancer research;anti-tumor immune response;ATAC-seq;Basic Science;Bioinformatics Shared Resource;Biological Assay;Biometry;Bone Marrow;Cancer Biology;cancer cell;Cancer Center Support Grant;Cancer Control;Cancer Prognosis;Catchment Area;CD4 Positive T Lymphocytes;Cell Physiology;cell type;Cells;Cellular biology;Chronic Myeloid Leukemia;clinical center;Clinical Sciences;Clinical Trials;Collaborations;community engagement;Community Outreach;Comprehensive Cancer Center;CXCR4 gene;Development;Doctor of Philosophy;drug development;drug discovery;Epigenetic Process;epigenome;Exhibits;Flow Cytometry;Funding;Future;Gene Expression;Genetic;Genetic Engineering;Genetic Transcription;Genomics Shared Resource;Goals;Grant;Heparanase inhibitors;high throughput screening;Histone Deacetylase;Histone Deacetylase Inhibitor;human imaging;Imaging Techniques;Immune;Immune response;Immunity;Immunologist;Immunology;Immunology procedure;Impairment;In Situ;Infrastructure;inhibitor;interest;Intestines;Investigational Therapies;Investments;Journals;Knowledge;Leadership;leukemic stem cell;Link;Location;Malignant Breast Neoplasm;Malignant neoplasm of ovary;Malignant Neoplasms;Mediating;Medicine;meetings;member;Metabolic;Metabolism;microbiome;Microscopy;Mitochondria;Modeling;Multiple Myeloma;neoplastic cell;neuro-oncology;Neuroendocrine Tumors;novel strategies;novel therapeutic intervention;novel therapeutics;nutrition;Obesity;Oxidative Stress;Pathway interactions;patient derived xenograft model;Peer Review Grants;Pharmaceutical Preparations;Phase I Clinical Trials;Phenotype;Population Sciences;Positron-Emission Tomography;Program Appropriateness;programs;Proteomics Shared Resource;Publications;Publishing;receptor;Regulation;Regulatory T-Lymphocyte;Renal Carcinoma;Renal Cell Carcinoma;Research;Research Activity;Research Personnel;Resistance;Resource Sharing;Role;Services;single-cell RNA sequencing;Site;stem cells;Strategic Planning;Stromal Cell-Derived Factor 1;structural biology;Surgical Oncologist;symposium;Technology;Testing;Therapeutic;therapy outcome;Tissue Procurements;Training;Training and Education;Transgenic Organisms;Translational Research;tumor;tumor behavior;Tumor Biology;Tumor Burden;Tumor Cell Biology;tumor growth;Tumor Immunity;tumor immunology;tumor metabolism;tumor microenvironment;tumor progression;Tumor-Derived;Tumor-Infiltrating Lymphocytes;Tyrosine Kinase Inhibitor;Urologic Surgical Procedures;Urology

PROJECT_TITLE: 01 - Cancer Biology & Immunology


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Crohn's Disease;Digestive Diseases;Genetics;Inflammatory Bowel Disease

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

PHR: Mucosal inflammatory diseases, such as Inflammatory Bowel Diseases (IBD), result in significant shifts in tissure metabolism that represent potential therapeutic targets. The proposed studies are designed to identify and test new inflammation-related metabolic pathways. Such studies should provide new avenues into our understanding of why inflammatory diseases develop, and in particular, how innate immune responses contribute to inflammatory resolution.

PI_NAMEs: COLGAN, SEAN P (contact)

PROGRAM_OFFICER_NAME: SENGER, STEFANIA

PROJECT_TERMS: Animal Model;antimicrobial;Area;bHLH-PAS factor HLF;Cell Culture System;Cell Hypoxia;Cell Line;chemically induced colitis;cohort;Colitis;design;Development;Disease;Disease Outcome;Environment;Epithelial Attachment;Epithelial Cell Junction;Epithelial Cells;Epithelium;Event;experimental study;field study;Gene Expression;Genes;Genetic Models;Genetic Transcription;genome-wide;gut inflammation;human tissue;Hypoxia;Hypoxia Inducible Factor;hypoxia inducible factor 1;Ileitis;in vivo;in vivo Model;Inflammation;Inflammatory;Inflammatory Bowel Diseases;Inflammatory Response;inhibitor;Innate Immune Response;insight;interest;intestinal epithelium;Laboratories;Metabolic Pathway;Metabolism;Molds;Molecular;Mucositis;Mucous Membrane;murine colitis;Mus;neutrophil;new therapeutic target;novel therapeutics;Pathway interactions;Permeability;pharmacologic;Phenotype;Physiological;Procollagen-Proline Dioxygenase;programs;promoter;Protac;Protein Isoforms;Proteins;Regulation;Resolution;response;Role;Signal Transduction;Stabilizing Agents;Technology;Testing;Therapeutic Agents;therapeutic target;Tissues;TNF gene;transcription factor;wound healing

PROJECT_TITLE: Hypoxia, HIF, and Mucosal Inflammation

STUDY_SECTION: GMPB

STUDY_SECTION_NAME: Gastrointestinal Mucosal Pathobiology Study Section[GMPB]


NIH_SPENDING_CATS: Biomedical Imaging;Biotechnology;Breast Cancer;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunotherapy;Orphan Drug;Precision Medicine;Prevention;Rare Diseases;Women's Health Research

PI_NAMEs: WAJAPEYEE, NARENDRA  (contact)

PROJECT_TERMS: Abbreviations;Alabama;Anatomy;animal imaging;anti-cancer research;Basic Cancer Research;Basic Science;bench to bedside;Bioinformatics;Biometry;Cancer Biology;Cancer Center Support Grant;Cancer Control;Cancer Patient;cancer prevention;cancer therapy;cancer type;Catchment Area;cGMP production;checkpoint inhibition;Chemoprevention;Clinical;Clinical Research;clinical translation;Clinical Trials;Collaborations;Combined Modality Therapy;Communities;community engagement;Community Outreach;Comprehensive Cancer Center;Cyclotrons;design;Diagnostic;Discipline;Disease;Disease Progression;DNA Repair;drug candidate;drug development;drug discovery;Drug resistance;Drug Targeting;Early Therapeutic-Clinical Trials Network;Educational workshop;effective therapy;EGFR inhibition;Enrollment;Epidermal Growth Factor Receptor;Flow Cytometry;Freedom;Funding;Future;Genetic Engineering;Genomics;Goals;Grant;Granzyme;Growth;Head and Neck Cancer;high throughput screening;human imaging;Hypoxia;Image;imaging agent;imaging biomarker;imaging facilities;Imaging Techniques;Immunotherapy;improved;in vivo;Industry;industry partner;Infrastructure;inhibitor;innovation;Institution;interdisciplinary collaboration;Investigational Therapies;investigator-initiated trial;Investments;Journals;Laboratories;Lead;Leadership;Malignant Breast Neoplasm;Malignant neoplasm of cervix uteri;Malignant neoplasm of prostate;Malignant neoplasm of urinary bladder;Malignant Neoplasms;medically underserved;Melanoma;member;Mentorship;Metabolism;microbiome;Microscopy;Modeling;Molecular;molecular imaging;Multiple Myeloma;neuro-oncology;new therapeutic target;next generation;Non-Small-Cell Lung Carcinoma;novel;novel strategies;novel therapeutic intervention;novel therapeutics;Obesity;PARP inhibition;Patient Recruitments;patient response;Patient Selection;Patients;Peer Review;Persons;Pharmaceutical Chemistry;Phase;phase 1 study;Phase I/II Trial;phase III trial;Physicians;Population Sciences;pre-clinical;Pre-Clinical Model;prevent;Prevention;prevention clinical trial;Preventive Clinical Trial;programs;Proteomics;Publications;Quality of life;quantitative imaging;Radiochemistry;Radiopharmaceuticals;Research;Research Activity;Research Personnel;Research Project Grants;Resistance development;Resource Sharing;Resources;Schools;Scientist;single cell analysis;Site;Strategic Planning;targeted treatment;Therapeutic;Therapeutic Agents;Therapeutic Clinical Trial;therapeutic development;Therapeutic Trials;Tissue Procurements;Training;Transgenic Organisms;Translating;translational cancer research;Translational Research;translational scientist;Treatment Efficacy;treatment response;triple-negative invasive breast carcinoma;tumor immunology;Underrepresented Minority;Underserved Population;Validation;Work;working group

PROJECT_TITLE: 02 - Experimental Therapeutics


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Orphan Drug;Rare Diseases

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Mutations in proteins that regulate cutting and rejoining of RNA (called RNA splicing) are common in many cancers, but the mechanism by which they cause cancer are unclear. We seek to determine defects in messenger RNA processing caused by these mutations. Our results can help inform development of novel therapies for these cancers.

PI_NAMEs: PILLAI, MANOJ M. (contact)

PROGRAM_OFFICER_NAME: SHARMAN, ANU

PROJECT_TERMS: Acute Myelocytic Leukemia;Alternative Splicing;Architecture;ATAC-seq;Automobile Driving;Biochemical;Biochemical Process;Biochemistry;Biological Assay;Biological Models;Biology;Cancer Etiology;cancer therapy;cancer type;Catalysis;Cell Line;Cells;Chemistry;Chromatin;Chronic Lymphocytic Leukemia;Clonal Evolution;CRISPR/Cas technology;Cytoplasm;Cytosine;Data;Data Set;Defect;Dependovirus;Development;Disease;disease model;Disparate;DNA;DNA replication fork;Epigenetic Process;epigenetic regulation;Event;Exons;Family;Gene Expression;Genetic Transcription;genome integrity;genome-wide;Genomic Instability;Growth;HDAC2 gene;Histone Deacetylase;Image;in vivo Model;Investigation;Label;Lead;Ligation;Link;Location;Malignant neoplasm of lung;Malignant Neoplasms;Mediating;Melanoma;Messenger RNA;Metabolic;Molecular;mRNA Export;mRNA Stability;mutant;Mutate;Mutation;Nature;nonsynonymous mutation;novel;novel therapeutics;nucleic acid structure;Oncogenes;Oncogenic;overexpression;Pathogenicity;Pathologic;Pathway interactions;Patients;Physiology;Play;Polymerase;Positioning Attribute;Production;Proteins;Recurrence;Regulation;Resolution;response;RNA;RNA library;RNA Polymerase II;RNA Processing;RNA Splicing;Role;S phase;S Phase Arrest;Sampling;Site;small hairpin RNA;small molecule inhibitor;Spliceosomes;SRSF2 gene;Structure;targeted treatment;Tissues;Transcript;Transcriptional Regulation;transcriptome sequencing;Translations;tumor;Tumor Suppressor Proteins;tumorigenesis;Uracil;Uveal Melanoma

PROJECT_TITLE: Biology of terminal R-loops in splicing factor mutant cancers


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biodefense and Related Countermeasures;Brain Disorders;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Dementia;Emerging Infectious Diseases;Health Services;Infectious Diseases;Mental Health;Mental Illness;Neurodegenerative;Neurosciences;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID;Prevention

ORG_NAME: NORTHERN CALIFORNIA INSTITUTE/RES/EDU

PHR: PROJECT NARRATIVE The proposed project is critical to understanding the long-term trajectory of COVID-19 and risk of neuropsychiatric disorders in late life. When considering the already existing public health crises of Alzheimer’s disease and related dementias and mental health conditions in adults aged 65 years and older, the degree to which COVID-19 may add to these crises is deeply concerning. Findings from the proposed project will inform intervention and prevention strategies for risk of age-related neurological complications and neurodegeneration and long-term management of these disorders in older adults with a history of COVID-19.

PI_NAMEs: BYERS, AMY LYNN (contact);KEYHANI, SALOMEH

PROGRAM_OFFICER_NAME: KWOK, RICHARD K

PROJECT_TERMS: 2019-nCoV;Acute;acute symptom;Admission activity;Adult;adverse outcome;Age;age related;age related neurodegeneration;aging related;Alzheimer's disease related dementia;Alzheimer's disease risk;American;Anosmia;Anxiety Disorders;Behavioral;Blood Vessels;Brain;Caregivers;Case Study;Central Nervous System;Clinical;Code;cohort;comorbidity;COVID-19;COVID-19 diagnosis;COVID-19 impact;COVID-19 neurocognitive sequelae;COVID-19 patient;COVID-19 severity;COVID-19 survivors;COVID-19 test;Data;Data Linkages;data resource;data sharing networks;Data Sources;Dementia;dementia risk;demographics;Development;Diagnosis;Disease;Disease Management;Early Intervention;Epidemiology;Event;functional decline;Functional impairment;Geography;Goals;Headache;Health;Health Services;Healthcare Systems;high risk;Hospitalization;human old age (65+);Immune response;improved;Incidence;Individual;Infection;innovation;International Classification of Diseases;Intervention;Knowledge;Laboratories;late life;Link;long term consequences of COVID-19;Medical;Medicare;Mental disorders;Mental Health;military veteran;mobility aid;Mood Disorders;Nature;Nerve Degeneration;Nervous System Disorder;Neurologic;neuropsychiatric disorder;neuropsychiatric sequelae of COVID-19;neuropsychiatry;Newly Diagnosed;Nursing Homes;older adult;older patient;Outcome;Outcome Assessment;pandemic impact;Patients;persistent symptom;Pharmaceutical Preparations;Phase;Phenotype;Policies;Polymerase Chain Reaction;post SARS-CoV-2 infection;Prevention strategy;Psyche structure;psychiatric comorbidity;psychiatric symptom;Psychological Impact;Psychoses;Public Health;Publishing;racial diversity;Recording of previous events;Recovery;Reporting;Research;response;Risk;Risk Adjustment;Risk Factors;Sampling;SARS-CoV-2 infection;SARS-CoV-2 negative;screening;Social Impacts;Source;Statistical Methods;Symptoms;United States Centers for Medicare and Medicaid Services;United States Department of Veterans Affairs;ventilation;Veterans;Veterans Health Administration

PROJECT_TITLE: Long-term Neuropsychiatric Sequelae of SARS-CoV-2 Infection in Late Life

STUDY_SECTION: NAME

STUDY_SECTION_NAME: Neurological, Aging and Musculoskeletal Epidemiology Study Section[NAME]


NIH_SPENDING_CATS: Biomedical Imaging;Biotechnology;Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Gene Therapy;Genetics;Human Genome;Immunotherapy;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Precision Medicine;Radiation Oncology;Rare Diseases

PI_NAMEs: NABORS, LOUIS B (contact)

PROJECT_TERMS: Address;Adult;Alabama;Animal Model;anti-tumor immune response;Biological;Biology;Brain;Brain Neoplasms;Cancer Center Support Grant;canine model;Catchment Area;Cell Communication;Cells;Central Nervous System Neoplasms;chemotherapy;Childhood;Childhood Glioma;Clinical;clinical care;Clinical Trials;cognitive function;Collaborations;Comprehensive Cancer Center;Creativeness;CRISPR library;cytokine;Deep South;design;Development;Direct Costs;Discipline;Education;efficacy testing;Enhancers;Environmental Risk Factor;Excision;Exposure to;Extramural Activities;Faculty;Funding;Future;G207;Generations;Genomics;Glioblastoma;Glioma;Glucose;Goals;Grant;Growth;Herpesviridae;Hypoxia;Image;Immune;immune activation;Immune response;Immunologics;Immunosuppression;improved;improved outcome;Industry;Infection;innovation;Innovative Therapy;Institution;inter-institutional;International;investigator-initiated trial;Journals;Laboratories;Laboratory Research;Lead;Leadership;Malignant Glioma;Malignant neoplasm of brain;Malignant Neoplasms;Manuscripts;medical schools;meetings;member;Metabolic Pathway;Metastatic malignant neoplasm to brain;microbiome;mouse model;Mus;N-Cadherin;Neoplasm Metastasis;neuro-oncology;New Agents;Newly Diagnosed;novel;novel therapeutics;Oncolytic;oncolytic herpes simplex virus;Oncolytic viruses;Operative Surgical Procedures;Paper;Pathway interactions;patient stratification;Patient-Focused Outcomes;Patients;pediatric patients;Phase;Phase I Clinical Trials;Physicians;Positron-Emission Tomography;precision medicine;preclinical study;Preclinical Testing;preservation;programs;Protons;Publishing;radiation resistance;Radiation therapy;Recurrence;Regimen;Research;research clinical testing;Research Personnel;Resistance;Resistance development;resistance mechanism;response;Risk;Role;Scientist;Seminal;Senior Scientist;Signal Transduction;Simplexvirus;standard of care;Strategic Planning;Stratification;Stromal Neoplasm;success;targeted treatment;temozolomide;Testing;Therapeutic;therapeutic development;therapy resistant;Tracer;Translations;treatment response;tumor;tumor growth;tumor immunology;tumor microenvironment;Work;working group

PROJECT_TITLE: 03 - Neuro-Oncology


NIH_SPENDING_CATS: Nutrition;Obesity;Stem Cell Research;Stem Cell Research - Embryonic - Human

PI_NAMEs: FERRANTE, ANTHONY W (contact)

PROJECT_TITLE: Enrichment Program


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Lung Cancer;Nutrition;Obesity;Palliative Care;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Tobacco;Tobacco Smoke and Health

PI_NAMEs: BROWN, ELIZABETH E (contact)

PROJECT_TERMS: Address;Affect;Alabama;anti-cancer research;Area;Award;Benchmarking;Black Populations;Black race;Body Weight decreased;Brain;Breast;Cancer Burden;Cancer Center Support Grant;Cancer Control;Cancer Detection;Cancer Etiology;cancer health disparity;Cancer Patient;cancer prevention;Cancer Survivor;Caregivers;Catchment Area;Cervical;clinical care;Collaborations;Colorectal Cancer;Communication;Communities;Community Clinical Oncology Program;community collaboration;community engaged research;community engagement;Community Outreach;Comprehensive Cancer Center;cost effectiveness;Data Set;Daughter;Death Rate;Development;Diet;Direct Costs;Disparity;Dissemination and Implementation;efficacious intervention;end of life;energy balance;Epidemiology;ethnic minority population;evidence base;Extramural Activities;Faculty;feasibility testing;Funding;Future;Goals;Guidelines;Health;Health behavior and outcomes;Health Disparities Research;Healthcare Systems;high risk;Human Papilloma Virus Vaccination;Immigrant;implementation science;improved;Incidence;innovation;inter-institutional;interdisciplinary collaboration;International;Intervention;Intervention Studies;Investments;Journals;Latinx;life span;Lung;Malignant Neoplasms;Medical center;medically underserved population;medication compliance;member;Minority;minority health;minority health disparity;modifiable risk;Molecular Chaperones;Morbidity - disease rate;Morehouse School of Medicine;mortality;multidisciplinary;Multiple Myeloma;National Cancer Institute;Natural History;new technology;Not Hispanic or Latino;novel;nutrition;Obesity;Observational Study;Outcome;Palliative Care;Pediatric Oncology Group;Peer Review;Persons;Physical activity;physical inactivity;Policies;Population;Population Sciences;Populations at Risk;Poverty;prevent;Primary Prevention;Productivity;Program Research Project Grants;programs;Prostate;Public Health;Publications;Quality of Care;racial minority population;Randomized, Controlled Trials;Research;Resource Sharing;Resources;Risk Behaviors;Risk Factors;Rural;rural counties;Rural Minority;Schools;Science;screening;Standardization;Strategic Planning;Subgroup;survivorship;Targeted Research;technology intervention;Testing;therapy design;tobacco control;Tobacco use;Training and Education;Translating;Translational Research;Translations;Underserved Population;Unhealthy Diet;United States Department of Veterans Affairs;Universities

PROJECT_TITLE: 04 - Cancer Control and Population Sciences


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Intellectual and Developmental Disabilities (IDD);Lung;Mental Health;Neurosciences;Pediatric;Pregnancy;Sleep Research;Women's Health Research

ORG_DEPT: BIOLOGY

PHR: PROJECT NARRATIVE More than half a million pregnant women each year have untreated sleep apnea, and it is not known whether this impacts her child’s brain development or function. In rats, we modeled the repeated episodes of low oxygen that a pregnant woman with sleep apnea would experience, and found that the male offspring’s developing brain is permanently altered, creating behavioral deficits and a constellation of learning and memory impairments reminiscent of autism spectrum disorder in humans. The studies proposed here will identify and manipulate maternal factors that may contribute to this neuropsychiatric pathology in order to identify novel therapeutic targets to prevent or reverse these adverse outcomes.

PI_NAMEs: BAKER, TRACY L;CAHILL, MICHAEL EDWARD;WATTERS, JYOTI J (contact)

PROGRAM_OFFICER_NAME: OREILLY, JULIA JIAQI

PROJECT_TERMS: Adolescent;Adult;Adult Children;adverse outcome;Affect;Animal Model;Animals;Attention;autism spectrum disorder;Automobile Driving;Awareness;Behavior;Behavioral;behavioral impairment;behavioral phenotyping;Blood;Brain;Breathing;Child;Chronic;Clinical;Cognitive;Cognitive deficits;comparative;Complex;cytokine;Data;Dendritic Spines;density;Development;Developmental Delay Disorders;Diagnosis;Disease;Drops;early onset;Etiology;Exhibits;experience;Experimental Models;Exposure to;Female;fetal;Fetus;Foundations;FRAP1 gene;Functional disorder;Future;Genetic;Health;health of the mother;High-Risk Pregnancy;hippocampal pyramidal neuron;Human;human model;Hyperactivity;Hypoxia;immune activation;Immune response;Impairment;Individual;Inflammation;Inflammatory;Interleukin-6;Learning;Life Experience;Link;male;maternal serum;Medial;Medical;Memory impairment;memory recognition;Modeling;Morbidity - disease rate;Mothers;Motivation;neural;Neurologic Dysfunctions;Neuronal Dysfunction;Neurons;Neurophysiology - biologic function;neuropsychiatric disorder;neuropsychiatry;new therapeutic target;Newborn Infant;offspring;Outcome;Oxygen;Paper;Pathologic;Pathology;Pathway interactions;Patient Compliance;Patients;Pattern;Perinatal;perinatal health;Phenotype;Physicians;Placenta;postnatal;Prefrontal Cortex;Pregnancy;pregnancy disorder;pregnant;Pregnant Women;prenatal;Prevalence;prevent;Rattus;Recurrence;repetitive behavior;response;Risk;Risk Factors;Rodent Model;screening;Severities;sex;sexual dimorphism;Signal Transduction;Sleep;Sleep Apnea Syndromes;social;social cognition;social deficits;Social Development;Source;Stimulus;Suggestion;Synapses;Testing;Third Pregnancy Trimester;Time;transmission process;Up-Regulation;Uterus;Vertebral column;virtual;Woman;Work

PROJECT_TITLE: Is gestational sleep apnea a previously unrecognized cause of maternal immune activation that predisposes male offspring to disease-relevant neural dysfunction?

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


NIH_SPENDING_CATS: Behavioral and Social Science;Breast Cancer;Cancer;Cervical Cancer;Clinical Research;Colorectal Cancer;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Lung Cancer;Prevention;Prostate Cancer;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Urologic Diseases;Women's Health Research

PI_NAMEs: NOLAN, TIMIYA S (contact)

PROJECT_TERMS: Address;Advocacy;Alabama;Alaska Native;American Indians;anti-cancer research;Area;Arkansas;Asian;Automobile Driving;Basic Science;black men;Black Populations;Black race;Brain;Breast;Breast Cancer Detection;breast cancer diagnosis;Cancer Burden;cancer care;Cancer Center Support Grant;Cancer Death Rates;cancer health disparity;cancer prevention;cancer therapy;Caring;Catchment Area;Cervical;Cervical Cancer Screening;Characteristics;clinical care;Clinical Sciences;clinical trial participant;Clinical Trials;Collaborations;Colorectal;Colorectal Cancer;Communication;Communities;community advisory board;community engaged research;community engagement;Community Outreach;community planning;Comprehensive Cancer Center;Country;County;COVID-19 impact;Data;Data Set;Databases;Death Rate;Decision Making;Diagnosis;Disparity;Early Diagnosis;Education and Outreach;ethnic disparity;ethnic diversity;Ethnic Origin;Evaluation;Evidence based intervention;Evidence based practice;Future;Gender;Gender Identity;geographic disparity;Geographic Locations;Health Services Accessibility;Health system;Hispanic;Home;Improve Access;Incidence;Infrastructure;Latinx;Leadership;Lesbian Gay Bisexual Transgender Queer;Logic;Louisiana;Lung;lung cancer screening;Malignant Breast Neoplasm;Malignant neoplasm of cervix uteri;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant Neoplasms;marginalized population;medically underserved;Medically Underserved Area;meetings;member;Minority;Minority Enrollment;Mississippi;Modeling;mortality;mortality disparity;multiple data sources;Multiple Myeloma;Native Hawaiian or Other Pacific Islander;NCI-Designated Cancer Center;Needs Assessment;next generation;Not Hispanic or Latino;obesity prevention;outreach;participant retention;patient navigation;Patients;Persons;Policies;Population;Population Heterogeneity;Population Sciences;Prevention;Program Development;programs;Prostate;Protocols documentation;Race;racial disparity;racial diversity;recruit;Research;Research Personnel;Research Support;Risk Factors;Risk Reduction;Rural;rural area;Rural Community;rural dwellers;rural residence;Scientist;screening;Screening for cancer;Services;Socioeconomic Status;Source;Strategic Planning;success;Surveys;survivorship;Therapeutic;Tobacco Use Cessation;Training;underserved community;urban area;Work

PROJECT_TITLE: Community Outreach and Engagement


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

ORG_CITY: CORAL GABLES

ORG_NAME: UNIVERSITY OF MIAMI CORAL GABLES

ORG_STATE: FL

PHR: PROJECT NARRITIVE  As a D-ARC, the Center for HIV and Research in Mental Health (CHARM) successfully re-ignited and dramatically grew high-impact meaningfully community-engaged research efforts and infrastructure at the University of Miami, located in a region of the U.S. that is one of the hardest hit geographic areas affected by the HIV/AIDS epidemic. Transitioning to a Full-ARC after successfully meeting D-ARC goals will capitalize on our trajectory, facilitating continued growth of multidisciplinary research addressing HIV-related mental health disparities and the impact of these disparities on the HIV care and prevention continua.

PI_NAMEs: SAFREN, STEVEN A (contact)

PROGRAM_OFFICER_NAME: GORDON, CHRISTOPHER M

PROJECT_TERMS: Achievement;Acquired Immunodeficiency Syndrome;Address;Affect;African American;African Caribbean;AIDS prevention;Award;base;Biometry;career;Caring;Collaborations;Communities;community advisory board;community engaged research;community engagement;Consent;cultural competence;Data Element;data management;Databases;design;Development;Disparity;Distributional Activity;effective intervention;Epidemic;Equity;Ethics;ethnic disparity;Evaluation;Evidence based intervention;Faculty;fall risk;Florida;Funding;Geographic Locations;Goals;Grant;Growth;Health Disparities Research;health disparity;high risk;HIV;HIV disparities;HIV/AIDS;Hot Spot;implementation science;improved;Individual;Infrastructure;innovation;Institution;Interdisciplinary Study;interest;International;Intervention;Investments;Laboratories;Latino;Lead;Leadership;Lesbian Gay Bisexual Transgender Queer;Libraries;Link;Location;Machine Learning;Measures;meetings;Mental Health;Mentors;Mentorship;Methodology;Methods;Minority;minority health disparity;Mission;multidisciplinary;multilevel analysis;National Institute of Mental Health;outcome disparities;Phase;Pilot Projects;Population;Population Heterogeneity;Positioning Attribute;Prevention;Process;programs;Public Health;Qualifying;Qualitative Research;racial disparity;recruit;Research;Research Design;Research Infrastructure;Research Personnel;Resources;Science;Scientist;Services;Shapes;social structure;Strategic Planning;Structure;success;System;tool;Training Activity;Underrepresented Minority;United States National Institutes of Health;Universities

PROJECT_TITLE: The University of Miami AIDS Research Center on Mental Health and HIV/AIDS - Center for HIV & Research in Mental Health (CHARM)


ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: Studying how cancer develops in animal models allows us to better understand human cancer and find new treatments. The proposed project is focused on the developing new tools that will allow researchers to turn on cancer signals by activating a light source implanted into mice. These new approaches will understand how cancers develop and find new treatments for early and late stages of cancer.

PI_NAMEs: KARGINOV, ANDREI V (contact);REHMAN, JALEES

PROGRAM_OFFICER_NAME: BECKER, STEVEN

PROJECT_TERMS: Animal Model;anti-cancer research;Automobile Driving;Biological Models;Breast Cancer Cell;Bypass;cancer cell;cancer initiation;Cancer Model;cancer type;Carcinogens;Catalytic Domain;Cells;circulating cancer cell;Complex;Data;design;Development;Disseminated Malignant Neoplasm;DNA;Early treatment;Endothelial Cells;Endothelium;Engineering;Ensure;Enterobacteria phage P1 Cre recombinase;Environment;Enzymes;Epithelial Cells;flexibility;Funding;Gene Expression;Goals;Grant;Guanosine Triphosphate Phosphohydrolases;Human;Implant;in vivo;interest;KDR gene;KRAS oncogenesis;Lesion;Light;Location;Lung;Malignant neoplasm of lung;Malignant Neoplasms;Mediating;Metastatic Neoplasm to the Lung;metastatic process;Methodology;Methods;Modeling;mouse model;Mus;Mutation;Nature;Neoplasm Metastasis;neoplastic cell;new technology;novel;novel strategies;Oncogenes;Oncogenic;optogenetics;Organ;overexpression;Pathway interactions;Patients;Pattern;Phase;Process;Protein Engineering;protein expression;Protein Kinase;Proteins;Publishing;Regulation;Reproducibility;research and development;Research Personnel;Role;Signal Transduction;Source;src-Family Kinases;System;Systems Development;therapy development;tool;translational scientist;tumor;tumor initiation;tumor progression;tumorigenesis

PROJECT_TITLE: Optogenetic Control of Tumor Initiation and Tumor Progression in vivo


NIH_SPENDING_CATS: Behavioral and Social Science;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PHR: Project Narrative for Other Components Please see Overall Component for Project Narrative.

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Administrative Efficiency;Administrative Supplement;Adolescent Medicine;AIDS prevention;Anthropology;Applications Grants;Architecture;Area;Award;base;Black race;Budgets;Cardiology;Caring;Collaborations;Communication;Communities;community advisory board;community engagement;COVID-19;Development;Discipline of Nursing;Disparity;Distal;Doctor of Philosophy;Ensure;Environment;Epidemic;Evaluation;Faculty;Funding;Goals;Grant;Growth;Health Disparities Research;health disparity;Health Sciences;Healthcare Systems;HIV;HIV disparities;HIV/AIDS;Hospitals;Human Resources;improved;Infrastructure;innovation;Institution;Latina;Latino;Latinx;Laws;Leadership;Lesbian Gay Bisexual Transgender Queer;Maintenance;Medical;Medicine;meetings;Mental Health;Mentors;minority health disparity;Monitor;multidisciplinary;next generation;Organizational Efficiency;organizational structure;Outcome;physical conditioning;Policies;Prevention;Process;Progress Reports;Psychiatry;Psychology;Public Health;Recommendation;Reporting;Research;Research Personnel;Research Project Grants;Resources;Role;Schools;Science;Scientist;Seminal;Services;skills;Strategic Planning;Structure;success;synergism;System;Training;United States National Institutes of Health;Universities;virtual platform;Work


NIH_SPENDING_CATS: Cancer

PROJECT_TERMS: Alabama;American Cancer Society;anti-cancer research;Applications Grants;Area;Biomedical Research;Cancer Center Support Grant;Catchment Area;community engagement;Community Outreach;Comprehensive Cancer Center;Contingency Fund;Country;Data;data submission;Development;empowerment;Engineering;Environment;expectation;experience;Extramural Activities;Faculty;Feedback;flexibility;Fostering;Foundations;Funding;Future;Goals;Grant;Growth;high reward;high risk;Image;improved;innovation;Institution;Investigation;Investments;Leadership;Malignant Breast Neoplasm;Malignant neoplasm of prostate;Malignant Neoplasms;meetings;member;Mentors;multidisciplinary;Neurology;Nutritional Science;Physics;Productivity;Program Reviews;programs;recruit;Research;Research Personnel;Research Priority;Research Project Grants;Resource Allocation;Resource Sharing;Resources;Review Committee;Science;Scientific Advances and Accomplishments;Scientist;Source;Strategic Planning;success;Synthesis Chemistry;Testing;Time;timeline;Training and Education;Translational Research;Vision;Writing

PROJECT_TITLE: Developmental Funds


NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Mental Illness;Neurosciences

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE  Perseverative behaviors are prominent, disabling, and often treatment-resistant symptoms of several neuropsychiatric disorders. We will use chemogenetics and fiber photometry in awake behaving mice to identify the mechanisms by which medial versus lateral orbitofrontal-striatal circuits regulate perseverative behavior. The proposed work could lead to novel therapeutic strategies for treating perseverative behavior.

PI_NAMEs: DULAWA, STEPHANIE C (contact)

PROGRAM_OFFICER_NAME: ROSSI, ANDREW F

PROJECT_TERMS: Acute;addiction;Address;Agonist;Anorexia Nervosa;autism spectrum disorder;awake;Behavior;Behavioral;Chronic;Corpus striatum structure;Data;Disabling;Fiber;Functional disorder;Genetic;Genetic study;Grooming;hippocampal pyramidal neuron;Human;Interneurons;Knowledge;Lateral;Link;Locomotion;Medial;Mediating;Methods;Mus;neural;neuroimaging;Neurons;neuropsychiatric disorder;novel therapeutic intervention;Obsessive-Compulsive Disorder;optogenetics;Outcome;Patients;pharmacologic;Photometry;pre-clinical;preclinical study;prevent;Regulation;Reporting;Resistance;response;Rewards;Rodent;Role;Route;Selective Serotonin Reuptake Inhibitor;Serotonergic System;Serotonin;Serotonin Receptor 5-HT1B;Signal Transduction;stereotypy;Symptoms;Technology;Testing;Work

PROJECT_TITLE: Dissecting the role of medial versus lateral orbitofrontal circuit activity in perseverative behavior

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


NIH_SPENDING_CATS: Biotechnology;Cancer

PI_NAMEs: VAN MEIR, ERWIN G. (contact)

PROJECT_TERMS: Abbreviations;Acceleration;Achievement;Address;Adoption;Advisory Committees;animal imaging;Artificial Intelligence;augmented intelligence;Basic Science;Bioinformatics;Bioinformatics Shared Resource;Biological Assay;Biometry;Breast Cancer Model;Budgets;Cancer Biology;Cancer Center Support Grant;Cancer Patient;Chromatin;Clinical;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;Communities;Comprehensive Cancer Center;cost effectiveness;Cryoelectron Microscopy;design;detector;Development;Dietary Intervention;Doctor of Philosophy;Education;Electron Microscope;Electrons;Ensure;Equipment;ERBB2 gene;Evaluation;Faculty;Flow Cytometry;Future;gene editing technology;Generations;Genetic Engineering;Genomics Shared Resource;Goals;Granzyme;gut microbiome;human imaging;Image;Immune;Individual;instrumentation;Intervention Studies;Investigational Therapies;Laboratories;Leadership;leukemic stem cell;Magnetic Resonance Imaging;Malignant Neoplasms;Manuscripts;Marketing;mass spectrometer;meeting reports;meetings;member;mesenchymal stromal cell;microbiome;Microscope;Microscopy;Mission;Modeling;Monitor;Mus;novel;Observational Study;Office of Administrative Management;operation;participant retention;Patient Recruitments;Patient-Focused Outcomes;Policies;Population;Positioning Attribute;programs;Proteomics Shared Resource;Publications;Quality Control;Radial;Radiopharmaceuticals;Recommendation;recruit;Regulation;Reporting;Research;Research Infrastructure;research study;Resource Development;Resource Sharing;response;Review Committee;satisfaction;Scientist;Services;single cell analysis;Speed;stem cell proliferation;Strategic Planning;Stromal Cell-Derived Factor 1;structural biology;Structure;Surveys;System;Technology;Therapeutic;Tissue Procurements;Training;Transgenic Organisms;Translational Research;Transposase;tumor immunology;Tyrosine Kinase Inhibitor;ultra high resolution;Validation;Vision;Writing

PROJECT_TITLE: Shared Resource Management


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: NORTHRIDGE

ORG_NAME: CALIFORNIA STATE UNIVERSITY NORTHRIDGE

PHR: Narrative. The future of our nation requires a well-trained scientific workforce that is inclusive and as diverse as the populations that comprise the USA. Unfortunately, not all demographic groups have access to the opportunities that prepare them for careers in basic biomedical sciences e.g. U.S. citizens and permanent residents belonging to certain ethnic groups are especially underrepresented in their participation in science, technology, engineering, mathematics (STEM) and in basic biomedical research careers. The proposed holistic program is integrated and developmentally-appropriate, that will enhance trainees’ critical thinking, self- efficacy, research capacity, and communication skills so that at graduation, these undergraduates will have the skills and mental agility to gain entry into top-tier research programs, to further science, and to become independent inclusive scientists and leaders in the scientific enterprise.

PI_NAMEs: HOGUE, CHERYL ;HONG, RAY L;ZAVALA, MARIAELENA B (contact)

PROGRAM_OFFICER_NAME: STAMM, JOYCE CHIN-CHIN NG

PROJECT_TERMS: Advisory Committees;African American;Biomedical Research;California;career;CCL7 gene;Cell Physiology;Communication;COVID-19;Critical Thinking;Disabled Persons;Disease;Disparity population;Doctor of Philosophy;Educational workshop;Eligibility Determination;Ethnic Population;Exclusion;Filipino;Future;Goals;graduate school;Growth;holistic approach;Humanities;Intervention;Language Arts;Latino Population;Mathematics;Mental Health;Mentors;Mexican Americans;Molecular Biology;Native Americans;next generation;nutrition;Outcome;Pacific Islander;Persons;Plants;Population;Problem Solving;Productivity;programs;Research;Research Personnel;Safety;scaffold;Science;Science, Technology, Engineering and Mathematics;Scientist;Self Efficacy;Series;skills;social disparities;southeast Asian;statistics;Structure;Student Persistence;Students;Training;undergraduate research;Universities;Water

PROJECT_TITLE: U-RISE Training the Next Generation of Basic Biomedical Researchers A Holistic Approach

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - D[TWD-D]


NIH_SPENDING_CATS: Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention

PI_NAMEs: SLECKMAN, BARRY P (contact)

PROJECT_TERMS: Abbreviations;Advisory Committees;Alabama;anti-cancer research;Appointment;Area;Basic Science;Cancer Biology;Cancer Burden;cancer care;Cancer Center Support Grant;Cancer Control;cancer health disparity;cancer imaging;Cancer Patient;cancer prevention;Catchment Area;Cities;Clinic;clinical center;Clinical Research;Clinical Sciences;Clinical Trials;Cognition;Committee Membership;Communication;Communities;community advisory board;community engagement;Community Outreach;Comprehensive Cancer Center;Data Analyses;Detection;Diagnostic;Disparity;diversity and inclusion;drug discovery;Early Diagnosis;Entrepreneurship;Evaluation;Faculty;Fostering;Goals;graduate student;Health Disparities Research;Health Occupations;Health Services Accessibility;Health system;improved;Informatics;innovation;Institution;Investigational Therapies;investigator-initiated trial;Lead;Leadership;Life;Malignant Neoplasms;medical schools;member;Mentors;Metabolism;minority patient;Mission;Morbidity - disease rate;multidisciplinary;NCI-Designated Cancer Center;neuro-oncology;next generation;novel;Obesity;operation;organizational structure;outreach;Participant;Persons;Population;Population Sciences;Prevention;Process;programs;Recording of previous events;Research;Research Personnel;Resource Sharing;Review Committee;Running;Schools;Science;Services;Strategic Planning;Structure;survivorship;Therapeutic Agents;Therapeutic Clinical Trial;therapeutic development;Therapeutic Trials;Time;Training;Training and Education;Translational Research;tumor immunology;undergraduate student;Universities;Vision;Work

PROJECT_TITLE: Leadership, Planning, and Evaluation


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PHR: Project Narrative for Other Components Please see Overall Component for Project Narrative. PAR-20-308 Guidelines Project Narrative: Do not complete. Note: ASSIST screens will show an asterisk for this attachment indicating it is required. However, eRA systems only enforce this requirement in the Overall component and applications will not receive an error if omitted in other components. SF424 Guidelines Overall Component: The "Project Narrative" attachment is required. Other Components: Refer to the specific FOA to determine whether the "Project Narrative" attachment is required for any Other Components. Note: The form may show ‘*’ indicating it is a required field, but it is only required for the Overall Component and the ‘*’ can be ignored for Other Components.

PI_NAMEs: BEHAR-ZUSMAN, VICTORIA  (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Advanced Development;Advisory Committees;Affect;Age;AIDS prevention;Applications Grants;Area;Award;Black race;career;career development;Caring;cohort;Collaborations;Communities;community engaged research;community partners;Data;design;Development;Development Plans;Discipline;Disparity;disparity reduction;Doctor of Philosophy;Educational workshop;Eligibility Determination;Ensure;Environment;Epidemic;Equity;ethnic minority;ethnic minority population;experience;Extramural Activities;Florida;Funding;Funding Mechanisms;Funding Opportunities;Future;gender minority group;Goals;Grant;Growth;Guidelines;health disparity;health equity;Health Transition;HIV;HIV disparities;HIV/AIDS;implementation science;Individual;innovation;Institution;International;Latinx;Manuscripts;Mental Health;Mentors;Mentorship;mid-career faculty;Minority Groups;minority health disparity;minority investigator;minority scientist;Mission;National Institute of Mental Health;next generation;Outcome;Peer Review;Peer Review Grants;Positioning Attribute;Postdoctoral Fellow;pre-doctoral;Productivity;professor;programs;racial disparity;racial minority;racial minority population;recruit;Reduce health disparities;Request for Applications;Research;Research Personnel;Resources;response;Science;Scientist;Services;Sexual and Gender Minorities;sexual minority group;skill acquisition;skills;Southeastern United States;success;synergism;System;Time;Training;Underrepresented Minority;United States National Institutes of Health;Universities;Work;Writing


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Patient Safety;Prevention

PI_NAMEs: MEHTA, AMITKUMAR N (contact)

PROJECT_TERMS: Abbreviations;Administrative Supplement;Adolescent and Young Adult;Aging;Alabama;anti-cancer research;Award;Cancer Biology;Cancer Burden;cancer care;Cancer Center Support Grant;cancer clinical trial;Cancer Control;Cancer Intervention;Cancer Patient;cancer therapy;Catchment Area;Classification;Clinical;Clinical Data;clinical investigation;Clinical Management;Clinical Protocols;Clinical Research;clinical trial participant;Clinical Trials;Collaborations;community engagement;Community Outreach;Comprehensive Cancer Center;Data;data integrity;data management;data quality;Data Reporting;Dedications;design;Development;Disease;Early Therapeutic-Clinical Trials Network;Education;Elements;Ensure;ethnic minority;Fostering;Health system;high standard;improved;Incidence;Infrastructure;Institution;Institutional Review Boards;Intervention;Intervention Trial;Investigational Therapies;investigator-initiated trial;Leadership;Letters;life span;Maintenance;Malignant Neoplasms;member;Mentors;Mentorship;Minority;Minority Participation;Monitor;neuro-oncology;Occupational activity of managing finances;outreach;Participant;participant safety;Patient Recruitments;patient safety;Patients;Persons;Population;Population Sciences;Procedures;Process;programs;protocol development;Protocols documentation;quality assurance;racial minority;Regulation;Reporting;Research Activity;Research Personnel;Resources;Review Committee;Risk;Safety;Services;Site;System;Time;Training;Training and Education;treatment trial;tumor immunology;Underserved Population;Universities;Woman;working group

PROJECT_TITLE: Clinical Protocol and Data Management