NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Neurosciences;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Narrative Adults with traumatic brain injury (TBI) have deficits in flexible and goal-directed behavior that have been linked to disruptions in the frontal lobes, but treatments designed to target the frontal lobes, and their functions, do not yield significant improvements in behavior, community reintegration, or independence. We propose that the frontal lobes may be too limiting a means for improving flexible and goal- directed behavior and aim to show the contribution of hippocampal relational memory to the observed behavioral dysfunction and poor outcomes in individuals with TBI. This proposal is unique in the field and uniquely promising for understanding the nature of behavioral dysfunction in TBI and, ultimately, improving rehabilitation intervention outcomes

PI_NAMEs: COHEN, NEAL J.;DUFF, MELISSA C (contact)

PROGRAM_OFFICER_NAME: UMOH, NSINI ALEASE

PROJECT_TERMS: Adaptive Behaviors;Address;Adult;Affect;Alzheimer's Disease;autism spectrum disorder;Basic Science;Behavior;behavior measurement;Behavioral;Behavioral Model;Brain;Chronic;clinical translation;Cognition;Cognitive;Communities;Community Integration;community reintegration;Compensation;Development;diagnostic biomarker;diagnostic tool;Diffuse;disability;Environment;executive function;flexibility;Foundations;frontal lobe;frontal lobe function;Functional disorder;functional independence;Generations;Goals;Heart;Heterogeneity;Hippocampus;Impairment;improved;Individual;Individual Differences;Intervention;Laboratories;Laboratory Study;Lead;Link;maladaptive behavior;Measures;Memory;Memory impairment;Mental Depression;Methods;Nature;neural;neural network;Neuroanatomy;neuroimaging;Neurologic;novel;operation;Outcome;Pathology;peer;Performance;poor communities;Prefrontal Cortex;prognostic tool;programs;psychosocial;recruit;Rehabilitation therapy;relational memory;Reporting;Research;response;Risk;Role;Sampling;Schizophrenia;Short-Term Memory;Stroke;Structure;support network;System;Testing;therapy design;Traumatic Brain Injury;treatment response;Update;visual tracking;Work

PROJECT_TITLE: Relational Memory as a Model of Behavioral (Dys)Function in Adults with Traumatic Brain Injury

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


ADMINISTERING_IC: DA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Drug Abuse (NIDA only);Mental Health;Neurosciences;Pediatric;Physical Activity;Physical Injury - Accidents and Adverse Effects;Prevention;Social Determinants of Health;Substance Misuse;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: SALT LAKE CITY

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PSYCHIATRY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE The ABCD Study consortium uses multimodal brain imaging, cognitive and clinical assessments, bioassays, mobile monitoring, and careful assessment of substance use, environment, psychopathological symptoms, and social functioning in 11,878 9-10 year-olds to be followed over 10 years, to determine the effects of substance use on adolescent brain and cognitive development. This ABCD Research Project Site will follow and assess participants enrolled in the study. These data will be shared with the scientific community to address a comprehensive range of questions concerning youth development.

PI_NAMEs: MCGLADE, ERIN ;RENSHAW, PERRY FRANKLIN;YURGELUN-TODD, DEBORAH A. (contact)

PROGRAM_OFFICER_NAME: DEEDS, BETHANY

PROJECT_TERMS: 10 year old;Address;Adolescence;Adolescent;adolescent substance use;Adult;adverse outcome;Affect;Age;Alcohol consumption;Alcohols;Anxiety;assessment application;Athletic Injuries;Behavior;Behavioral;Bioinformatics;Biological;Biological Assay;Biology;Brain;Brain imaging;Caffeine;Calendar;Cannabis;Child;Child Health;Childhood;Clinical assessments;Cognition;Cognitive;cognitive development;cognitive testing;cohort;college;Communities;Country;Data;Data Analyses;Decision Making;design;Development;emerging adult;Emotional;emotional factor;Enrollment;Ensure;Environment;Environmental Exposure;Environmental Risk Factor;Epidemiology;Ethics;Event;experience;Feeling suicidal;Female;follow-up;Funding;gene interaction;Genetic;Health;Impairment;Individual;Informatics;informatics infrastructure;Interview;Life;Link;Longitudinal Studies;marijuana use;Mental Depression;Mental disorders;Mental Health;Methodology;Methods;mobile application;mobile computing;Monitor;multimodality;neural;Neurocognition;Neurocognitive;neurodevelopment;neuroimaging;Neuropsychological Tests;novel;Occupations;Outcome;Parents;Participant;participant enrollment;participant retention;Pathway interactions;Persons;Physical activity;physical conditioning;Privatization;Process;Protocols documentation;Psychopathology;Qualifying;recruit;Recurrence;Registries;Research;research and development;Research Personnel;Research Project Grants;Resource Informatics;Resources;response;retention rate;Risk;Role;Sampling;Schools;Science;Secure;Severities;Siblings;Site;Sleep;sleep pattern;social;Social Functioning;Social isolation;social media;Specific qualifier value;Sports;Standardization;substance use;Symptoms;Technology;Teenagers;Telephone;temporal measurement;Text;Time;Tobacco;Tobacco use;Training;Traumatic Brain Injury;trend;Triplet Multiple Birth;tv watching;Twin Multiple Birth;United States;Utah;vaping;Video Games;young adult;Youth

PROJECT_TITLE: 1/21 ABCD-USA CONSORTIUM: RESEARCH PROJECT SITE AT U UTAH


ADMINISTERING_IC: CA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer

ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

ORG_STATE: CA

PHR: PROTOCOL REVIEW AND MONITORING SYSTEM  PROJECT NARRATIVE Per PAR-20-043, a Project Narrative is not required for this component.

PI_NAMEs: HUI, CHRISTINE  (contact)

PROJECT_TERMS: Affect;Anatomy;anti-cancer research;Area;authority;Authorization documentation;California;Cancer Center;Cancer Center Support Grant;cancer clinical trial;cancer health disparity;cancer survival;Catchment Area;Clinical;Clinical Cancer Center;Clinical Management;clinical practice;Clinical Research;Clinical Sciences;Clinical Trials;Collaborations;Committee Membership;Comprehensive Cancer Center;County;Detection;Disease;Ensure;Faculty;Family;Goals;Guidelines;improved outcome;Industry;innovation;Institution;Intervention;Investigation;investigator-initiated trial;Knowledge;Malignant Neoplasms;Minority Groups;Mission;Monitor;multidisciplinary;operation;Operations Research;Oranges;Policies;population health;Prevention;Procedures;Process;Protocols documentation;Public Policy;Qualifying;Research;Research Personnel;research study;Resources;Safety;Science;Support System;System;Translations;Universities

PROJECT_TITLE: Protocol Review and Monitoring System (PRMS)


PHR: LEADERSHIP, PLANNING & EVALUATION  PROJECT NARRATIVE Per PAR-20-043, a Project Narrative is not required for this component.

PI_NAMEs: FUNES, MELANIE  (contact)

PROJECT_TERMS: Address;anti-cancer research;Basic Science;Cancer Center;Cancer Center Support Grant;cancer research center director;Catchment Area;Clinical Sciences;Collaborations;Communities;Comprehensive Cancer Center;County;Decision Making;Development;Effectiveness;Ensure;Equity;Evaluation;Family;Feedback;Fostering;Funding;Goals;Growth;improved;improved outcome;Individual;innovation;Leadership;Malignant Neoplasms;Needs Assessment;operation;Oranges;Organization and Administration;organizational structure;outreach;outreach program;Persons;Population Sciences;Positioning Attribute;prevent;Process;programs;Research;Resource Sharing;Resources;Strategic Planning;Training and Education;Translational Research;Vision;Work

PROJECT_TITLE: Leadership, Planning and Evaluation


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Clinical Research;Duchenne/ Becker Muscular Dystrophy;Muscular Dystrophy;Pediatric;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: DAVIS

ORG_DEPT: PHYSICAL MEDICINE & REHAB

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: PROJECT NARRATIVE This project aims to reveal mechanisms of communication between skeletal muscle extracellular matrix and the fibroadipogenic progenitor cells that produce progressive fibrotic cycles in muscular disease. The robustness of the fibrotic cycle will be tested by interrupting the pro-fibrotic signaling through clinical gene therapy of the initiating muscle instability. Investigation of these mechanisms and their durability using innovative methodologies in mice and humans with fibrotic muscular dystrophy uncover specific targets for therapies to block and reverse progressive fibrotic pathologies and augment the efficacy of potential gene therapy.

PI_NAMEs: SMITH, LUCAS R (contact)

PROGRAM_OFFICER_NAME: LINDHURST, MARJORIE JEAN

PROJECT_TERMS: Adopted;antifibrotic treatment;Apoptosis;Apoptotic;Architecture;Area;Biocompatible Materials;Biopsy;Cells;Clinical;Coculture Techniques;Collagen;Collagen Fiber;Communication;Contracts;Contracture;crosslink;Defect;density;Development;Duchenne muscular dystrophy;Dystrophin;Engineering;Environment;Excision;Extracellular Matrix;Feedback;Fibrillar Collagen;Fibrosis;functional decline;functional improvement;functional restoration;Gel;gene therapy;Genetic Transcription;Health;Human;Impairment;In Situ;in vivo;Infusion procedures;Injections;Injury;innovation;Interruption;Investigation;Joints;Knowledge;lipid biosynthesis;mdx mouse;mechanical properties;mechanical signal;Mechanics;Mesenchymal Cell Neoplasm;mesenchymal stromal cell;Methodology;micro-dystrophin;Mobility decline;Monitor;mouse model;Mouse Strains;Mus;Muscle;Muscle function;muscle progenitor cell;muscle regeneration;Muscle rehabilitation;muscle stiffness;Muscular Dystrophies;Myofibroblast;myogenesis;Myopathy;Natural regeneration;novel;Pathologic;Pathology;Phenotype;prevent;Prior Therapy;Production;Profibrotic signal;progenitor;Proliferating;Property;regeneration following injury;regeneration function;regenerative;Regulation;repaired;Research;response;restoration;Role;Signal Transduction;Skeletal Muscle;stem cell fate;stem cell proliferation;stem cells;Stretching;Structure;success;System;targeted treatment;Testing;therapy development;Tissues;Treatment Efficacy;Variant;Weight-Bearing state;Work

PROJECT_TITLE: Interdependency of fibroadipogenic progenitors and extracellular matrix that drive skeletal muscle fibrosis

STUDY_SECTION: SMEP

STUDY_SECTION_NAME: Skeletal Muscle and Exercise Physiology Study Section[SMEP]


ADMINISTERING_IC: NS

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: WASHINGTON

ORG_DEPT: NEUROSCIENCES

ORG_NAME: GEORGETOWN UNIVERSITY

ORG_STATE: DC

PHR: Project Narrative Neural degeneration of the cholinergic neurons within the pedunculopontine nucleus (PPN) correlates with the severity of motor impairment in Parkinson's disease (PD). However, the role of the PPN within the basal ganglia circuit for motor output has not yet been comprehensively dissected making it unclear how its degeneration contributes to motor deficits in PD. This study is relevant to the mission of NIH because it aims to characterize the synaptic properties, regional connectivity, and closed-loop circuits between the major inhibitory basal ganglia nuclei, SNr and GPe, and rostral and caudal PPN to suggest new therapeutic targets.

PI_NAMEs: FALLAH, MICHEL  (contact)

PROGRAM_OFFICER_NAME: CHEN, DAOFEN

PROJECT_TERMS: Address;Adult;Anatomy;Axon;Back;Basal Ganglia;behavioral outcome;Brain region;Calcium;Cell Nucleus;Cells;cholinergic;cholinergic neuron;clinically relevant;Communication;confocal imaging;Data;Deep Brain Stimulation;differential expression;Differentiation Antigens;disease model;Dissection;dopaminergic neuron;Electrophysiology (science);experimental study;Extracellular Matrix Proteins;Feedback;Gait;Gait abnormality;Ganglia;Genetic;Globus Pallidus;Glutamates;Heterogeneity;Image;Immunohistochemistry;improved;interest;Knowledge;Label;Lesion;Maps;Membrane Potentials;Midbrain structure;Mission;Modeling;Molecular;molecular marker;Motor;motor deficit;motor disorder;motor impairment;Motor output;Motor Pathways;Movement;Mus;nephronectin;Nerve Degeneration;neural circuit;Neurons;new therapeutic target;Optics;optogenetics;Outcome;Output;Parkinson Disease;patch clamp;Pathway interactions;Patients;Pattern;pharmacologic;postsynaptic;Posture;posture instability;Property;protein expression;Proteins;response;Rest Tremor;Rodent;Rodent Model;Role;selective expression;Sensory;Severities;Severity of illness;Signal Transduction;Structure;Subgroup;Substantia nigra structure;Synapses;Testing;Thalamic Nuclei;tool;United States National Institutes of Health

PROJECT_TITLE: Dissecting functional subgroups and closed-loop circuits between the pedunculopontine nucleus and the basal ganglia


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases;Social Determinants of Health

PHR: COMMUNITY OUTREACH & EDUCATION  PROJECT NARRATIVE Per PAR-20-043, a Project Narrative is not required for this component.

PI_NAMEs: TANJASIRI, SORA P (contact)

PROJECT_TERMS: Address;Advocacy;African American population;Asian Americans;Attitude;authority;Behavioral;Breast;California;Cancer Burden;cancer care;Cancer Center;Cancer Center Support Grant;cancer education;cancer health disparity;Cancer health equity;Cancer Patient;cancer prevention;cancer research center director;cancer risk;Catchment Area;Chinese;Clinic;Clinical;clinical trial participant;Colon;Communication;Communities;community based participatory research;community center;community clinic;community collaboration;community engagement;Community Health;Community Health Education;community organizations;Community Outreach;Comprehensive Cancer Center;County;COVID-19;Data Analyses;Data Collection;data visualization;demographics;design;Detection;Early Diagnosis;Education;Education and Outreach;Education Projects;Educational process of instructing;Ensure;Environmental Risk Factor;Equity;ethnic diversity;Ethnic Origin;Evaluation;evidence base;Family;Federally Qualified Health Center;Female;Funding;Future;Geography;Goals;healing;Health;Health Educators;Health Promotion;Hispanic-serving Institution;Home;Human Papilloma Virus Vaccination;improved;Incidence;Income;Individual;Institution;Intervention;Koreans;Language;Latino Population;Leadership;life span;Longevity;Lung;male;Malignant neoplasm of cervix uteri;Malignant neoplasm of liver;Malignant Neoplasms;malignant stomach neoplasm;Melanoma;member;Minority;Mission;Modeling;Monitor;mortality;Multiple Myeloma;Native Americans;neoplasm registry;Not Hispanic or Latino;Oranges;Pacific Island Americans;Personal Satisfaction;Policies;Population;Population Heterogeneity;Poverty;prevent;Prevention trial;programs;Prostate;Public Health;Race;recruit;Research;Research Personnel;research study;research to practice;residence;Risk Factors;Screening for cancer;service coordination;social;socioeconomic diversity;Strategic Planning;surveillance data;survivorship;Translating;treatment trial;Vietnamese;Vision;Woman;Work

PROJECT_TITLE: Community Outreach and Engagement


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: HOUSTON

ORG_DEPT: PEDIATRICS

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: The proposed research is relevant to public health because low vitamin D levels are associated with multiple diseases including diabetes and hypertension. Additional studies are needed to understand how vitamin D receptors in the brain control glucose. The results from this project will provide fundamental knowledge needed for the development of potentially novel strategies to improve the care of diabetes.

PI_NAMEs: SISLEY, STEPHANIE RENEE (contact)

PROGRAM_OFFICER_NAME: COOKE, BRAD

PROJECT_TERMS: Acute;Affect;Agonist;American;Animal Feed;Animals;Blood Glucose;blood glucose regulation;Body Weight;Brain;brain control;Calcitriol;Caring;Cells;Clinical Trials;Data;Development;Diabetes Mellitus;diabetes mellitus therapy;diabetes pathogenesis;Diet;dietary;dietary manipulation;dihydroxy-vitamin D3;Disease;effective therapy;Energy Intake;Enterobacteria phage P1 Cre recombinase;Equilibrium;euglycemia;experimental study;Fasting;Future;Genetic;Genetic Models;Genomics;Glucose;glucose production;glucose tolerance;Glucose tolerance test;Goals;Grant;High Fat Diet;Hypertension;Hypothalamic structure;Immunohistochemistry;impaired glucose tolerance;improved;Individual;Inflammation;innovation;insight;Insulin Resistance;intraperitoneal;Knowledge;Ligands;Literature;Mediating;Medical Care Costs;Methods;Modeling;Molecular;mouse model;Mus;neural circuit;neuronal circuitry;Neurons;new therapeutic target;Non-Insulin-Dependent Diabetes Mellitus;novel;novel strategies;Obesity;Other Genetics;Peripheral;Physiological;Population;prevent;Property;protective effect;Public Health;Publishing;receptor expression;receptor function;Regulation;Research;response;Risk;Rodent;Role;single cell genomics;single-cell RNA sequencing;stem;Techniques;Testing;Therapeutic;Therapeutic Agents;Thinness;tool;transcriptomics;translating ribosome affinity purification and RNA-sequencing;Viral;Vitamin D;Vitamin D3 Receptor;Weight;Work

PROJECT_TITLE: Brain VDR Regulate Glucose Balance

STUDY_SECTION: BNRS

STUDY_SECTION_NAME: Behavioral Neuroendocrinology, Neuroimmunology, Rhythms, and Sleep Study Section [BNRS]


ADMINISTERING_IC: HD

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Patient Safety;Pediatric;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: PROJECT NARRATIVE Despite representing only 1% of all children in the US, children with medical complexity (CMC) account for one third of hospital expenditures and have 30-day readmission rates of 20%. The overarching goal of this study is to design a heath literacy-informed tool and test its efficacy in improving parent comprehension of/adherence to discharge instructions and reducing post-hospitalization morbidity for CMC. This study has the potential to transform discharge processes for CMC, providing a model for a family-centered, evidence-based, scalable approach to achieve National Academy of Medicine goals of safe, effective, patient-centered, and equitable transitions.

PI_NAMEs: GLICK, ALEXANDER  (contact)

PROGRAM_OFFICER_NAME: KING, TRACY

PROJECT_TERMS: Academy;Accident and Emergency department;Acute;Address;Adherence;Adult;Adverse drug event;Adverse event;Affect;Antibiotics;Appointment;Asthma;Back;Caregivers;Caring;Cellulitis;Child;Childhood;Chronic;Clinic;Communication;Complex;Comprehension;Congenital Abnormality;Counseling;Data;Dependence;design;Development;Diagnosis;digital;Discharge Plannings;Education;Educational process of instructing;effectiveness study;efficacy testing;Electronic Health Record;Elements;Environment;Epilepsy;Equipment;Equity;Evaluation;evidence base;Expenditure;experience;Family;Family dynamics;family management;Financial Hardship;future implementation;Goals;Health;health literacy;high risk;Home;hospital readmission;Hospitalization;Hospitals;Household and Family;implementation science;implementation study;improved;Individual;Infection;Inpatients;Instruction;Intervention;Interview;Joints;Knowledge;Language;Lead;Life Expectancy;Link;Liquid substance;literacy;Malignant Neoplasms;Medical;medical schools;medication administration;Medication Errors;Medicine;Mentors;Mentorship;Modeling;Morbidity - disease rate;multidisciplinary;multiple chronic conditions;Outcome;Outpatients;Parents;patient oriented;Patients;Pediatric Hospitals;pediatrician;Pharmaceutical Preparations;Physicians;Pneumonia;Process;Provider;provider-level barriers;Qualitative Methods;Qualitative Research;Randomized, Controlled Trials;readmission rates;Recommendation;Regimen;Research;Research Methodology;Research Personnel;respiratory;Risk;Route;Sampling;Self Management;Shunt Device;side effect;skills;Social support;stakeholder perspectives;Stress;Structure;Symptoms;System;Technology;Testing;Time;tool;tool development;Training;Treatment Efficacy;United States Agency for Healthcare Research and Quality;usability;user centered design;Visit;Work;Writing;Yin

PROJECT_TITLE: Promoting Safe Transitions from Hospital to Home for Children with Medical Complexity: A Health Literacy-Informed and Family-Centered Approach

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Health, Behavior, and Context Study Section[CHHD-M]


PHR: SHARED RESOURCE MANAGEMENT  PROJECT NARRATIVE Per PAR-20-043, a Project Narrative is not required for this component.

PI_NAMEs: WATERMAN, MARIAN L (contact)

PROJECT_TERMS: Address;anti-cancer research;Area;base;Basic Science;Behavioral Sciences;biobehavior;Biology;Biostatistics Shared Resource;Cancer Center;Cancer Center Support Grant;cancer clinical trial;Cancer Control;Catchment Area;Clinical;Clinical Cancer Center;Clinical Research;Clinical Sciences;Clinical Trials;Collaborations;Communication;Comprehensive Cancer Center;Consultations;cost;cost effective;cost effectiveness;County;Development;Discipline;Doctor of Philosophy;Effectiveness;Ensure;Equipment;Evaluation;Exercise;Family;Feedback;Financial Support;Funding;Future;Genomics;Goals;Growth;Guidelines;Health Services Accessibility;Image;improved outcome;in vivo;Individual;information gathering;innovation;Institution;International;Joints;Journals;Leadership;Malignant Neoplasms;Mass Spectrum Analysis;meetings;member;Methodology;Mission;Molecular;Monitor;new technology;Office of Administrative Management;Optics;Oranges;Outcome;Patients;Performance;Persons;physical science;Play;Population Sciences;Positioning Attribute;prevent;Process;Productivity;programs;Publications;Reporting;Research;Research Support;Resource Sharing;Resources;Services;Strategic Planning;Structure;Surveys;Systems Biology;Technology;tissue resource;Transgenic Mouse Facility;Translational Research;tumor metabolism;Vision;Work;working group

PROJECT_TITLE: Shared Resource Management


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics

ORG_CITY: Nashville

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: VANDERBILT UNIVERSITY

PHR: Project Narrative We will use high-throughput mutagenesis to map which amino acids in the protein sequence are essential for function and which subset of these are involved in communicating the coupling of DNA binding and ATP hydrolysis in a DNA polymerase clamp loader, a member of the family of complex molecular machines called AAA+ ATPases. We will also use statistical models trained on genome sequences of clamp loaders from diverse organisms to infer the essential constraints on and between amino acids in clamp loaders and test these inferences in a biological context. The aims of this project represent a unified body of work to use new assay systems to understanding clamp loader and AAA+ mechanism, and to test the potential for engineering complex macromolecular machines using our sequence-based design.

PI_NAMEs: KURIYAN, JOHN  (contact)

PROGRAM_OFFICER_NAME: REDDY, MICHAEL K

PROJECT_TERMS: Amino Acid Sequence;Amino Acids;Architecture;ATP Hydrolysis;ATP phosphohydrolase;Bacteria;Bacteriophage T4;Bacteriophages;Base Sequence;Behavior Control;Binding;Biochemical;Biological;Biological Assay;cell behavior;Cells;Closure by clamp;Communication;Complex;Computer Models;Conserved Sequence;Coupling;Data;design;Diffuse;Disease;Dissociation;DNA;DNA Binding;DNA biosynthesis;DNA-Directed DNA Polymerase;Engineering;enhancer binding protein;Escherichia coli;Eukaryotic Cell;Evolution;experimental study;Family;Family member;fitness;Genetic Epistasis;Genome;Genomics;Goals;high throughput screening;Homologous Gene;Human;Hydrogen Bonding;Hydrolysis;insight;Libraries;Link;Machine Learning;macromolecular assembly;Macromolecular Complexes;Maps;Mechanics;member;Modeling;Molecular Machines;Mutagenesis;mutant;Mutation;Nature;novel;Organism;Orthologous Gene;Pattern;Performance;preservation;Process;Property;protein complex;Protein Engineering;protein function;protein oligomer;Proteins;Research;response;Set protein;Site;Slide;Speed;Statistical Models;Stimulus;System;Testing;three dimensional structure;Training;Transcription Initiation;Transcriptional Regulation;transmission process;Variant;Virus;Work

PROJECT_TITLE: Mechanism and Evolutionary Design of DNA Polymerase Clamp Loaders.

STUDY_SECTION: MSFC

STUDY_SECTION_NAME: Macromolecular Structure and Function C Study Section[MSFC]


ADMINISTERING_IC: HL

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Heart Disease

ORG_CITY: BOSTON

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

ORG_STATE: MA

PHR: Project Narrative We offer a comprehensive two-year multidisciplinary training program in cardiovascular epidemiology for MDs and PhDs to pursue a successful scientific research career addressing contemporary training needs of the specialty. The program will graduate five postdoctoral scholars every two years in three different training tracks (clinical translational epidemiology, statistical genetics-genomics, and bioinformatics-computational biology), with enrollment of at least 50% women and 20% scholars from underrepresented groups. We will provide our scholars with multidisciplinary training that includes a broad educational curriculum to develop core competencies, research projects under the supervision of outstanding faculty, comprehensive mentorship, and appropriate career and professional developmental support to ensure their future success.

PI_NAMEs: XANTHAKIS, VANESSA  (contact)

PROGRAM_OFFICER_NAME: COADY, SEAN

PROJECT_TERMS: cardiovascular disorder epidemiology;multidisciplinary;Training Programs

PROJECT_TITLE: Multidisciplinary Training Program in Cardiovascular Epidemiology

STUDY_SECTION: NITM

STUDY_SECTION_NAME: NHLBI Institutional Training Mechanism Study Section[NITM(OA)]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE We have discovered a new pathway, which we have termed Secretory Autophagy during Lysosome Inhibition (SALI), that promotes packaging and secretion of extracellular vesicles and particles. This proposal will dissect whether and how SALI controls the delicate balance of secretion and intracellular trafficking of disease-relevant proteins in microglia to promote neurodegeneration in Frontotemporal Dementia.

PI_NAMEs: DEBNATH, JAYANTA ;HUANG, ERIC J (contact)

PROGRAM_OFFICER_NAME: LI, TONG

PROJECT_TERMS: Affect;age related;age related neurodegeneration;aging brain;Amyloid beta-Protein;Autophagocytosis;Autophagosome;Brain;Catabolism;Cell secretion;cell type;Coculture Techniques;Defect;Degradation Pathway;Disease;Equilibrium;Exocytosis;extracellular;extracellular vesicles;Follow-Up Studies;Frontotemporal Dementia;Functional disorder;Funding;Genetic;glial activation;Gliosis;Homeostasis;hyperphosphorylated tau;Inflammation Mediators;Inflammatory Response;insight;Intracellular Transport;Laboratories;lipid metabolism;lipid transport;Lipids;loss of function;Lysosomes;Mediating;Microglia;misfolded protein;Modeling;Mus;MYO5A gene;Myosin ATPase;nanoparticle;Nerve Degeneration;Neurodegenerative Disorders;Neuroglia;neuron loss;Neurons;neurotoxic;neurotoxicity;Organelles;particle;Pathogenesis;Pathology;Pathway interactions;PGRN gene;Phenotype;Phospholipids;Process;protein TDP-43;Proteins;Proteomics;proteostasis;receptor;Regulation;RNA-Binding Proteins;Role;Signal Transduction;Testing;Toxic effect;trafficking;transcriptomics;Up-Regulation;Vesicle;Work

PROJECT_TITLE: Endolysosomal defects in secretory autophagy and microglial toxicity in FTD

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Contraception/Reproduction;Dementia;Estrogen;Genetics;Menopause;Neurodegenerative;Neurosciences;Prevention;Women's Health Research

ORG_DEPT: PSYCHOLOGY

ORG_NAME: RICE UNIVERSITY

PHR: Project Narrative  Alzheimer’s disease (AD) is significantly more common in females than males, and females carry greater risk for developing AD; however, the reason for these sex differences remains unknown. The proposed project aims to explore the interaction between the menopausal transition and accompanied decreases in estrogen on brain networks supporting memory in females at risk for AD. The insight gained from this research will increase our understanding of the neurobiological and neuroendocrine processes underlying sex differences in AD and will aid the early detection of AD, which is crucial for intervening and slowing disease progression.

PI_NAMEs: BALLARD, HANNAH  (contact)

PROGRAM_OFFICER_NAME: ROBERTS, LUCI

PROJECT_TERMS: Abeta clearance;Acceleration;Address;Adult women;Age;age difference;age effect;age-related disease;Aging;aging brain;Alleles;Alzheimer disease detection;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease risk;Alzheimer’s disease biomarker;Amenorrhea;apolipoprotein E-4;Apolipoproteins;Atrophic;Behavior;Behavioral;Biological;Brain;brain health;career;Clinical;Cognition;Cognitive;cognitive performance;Complex;Data;Development;Discrimination;Disease;Disease Progression;Disparate;Early Diagnosis;Emotional;Endocrine;endophenotype;Estradiol;Estrogen decline;Estrogens;Exhibits;experience;Female;functional MRI scan;Genetic Risk;genetic risk factor;Gonadal Steroid Hormones;Health;healthy aging;High Risk Woman;Hippocampus;hormone therapy;Hyperactivity;Impaired cognition;innovation;insight;Intervention;Longevity;Magnetic Resonance Imaging;male;Measures;medial temporal lobe;Mediating;Memory;Menopause;Menstrual cycle;Mentorship;Methods;middle age;Neurobiology;neuroimaging;neuroprotection;Neurosecretory Systems;normal aging;novel strategies;older adult;Outcome;Pathogenesis;Pathology;Performance;Perimenopause;Phase;Postmenopause;pre-clinical;Predisposition;Premenopause;Prevention;Process;reproductive;reproductive hormone;reproductive senescence;Research;Resolution;Rest;Risk;Risk Factors;salivary assay;sex;Sex Differences;Signal Transduction;skills;Stimulus;support network;Symptoms;Therapy trial;Time;training opportunity;Women's prevalence;Work

PROJECT_TITLE: Estrogen Declines with Menopause: Impacts on the Medial Temporal Lobe Network and Emotional Memory in Aging Females at Genetic Risk for Alzheimer’s Disease


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Arthritis;Genetics;Immunotherapy

ORG_CITY: HANOVER

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: Narrative. Targeting of immune negative checkpoint regulator (NCR) pathways is revolutionizing the treatment of human cancers and has established that these pathways are proven clinical targets in human disease. VISTA (V-region Immunoglobulin-containing Suppressor of T cell Activation), is a recently identified, NCR ligand/receptor and we have produced antibodies that can trigger through VISTA and induce immune suppression. Our studies show that triggering through VISTA can exert significant impact on the inflammation mediated by the innate immune system. The studies presented will provide comprehensive insight into the mechanisms of suppression of innate immunity by anti-VISTA. .

PI_NAMEs: MABAERA, RODWELL ;SKOPELJA-GARDNER, SLADJANA  (contact)

PROGRAM_OFFICER_NAME: RICE, JEFFREY S

PROJECT_TERMS: Ablation;adaptive immunity;Address;Adhesions;Anti-Inflammatory Agents;Antibodies;Apoptosis;Arthritis;Autoimmune;Autoimmune Diseases;autoimmune pathogenesis;Binding;Biochemistry;Biology;Cells;chemokine;chemokine receptor;Chemotaxis;Chromatin;chronic autoimmune disease;Clinical;Conceptions;CTLA4 gene;Data;Development;Disease;disease model;Epigenetic Process;Event;Experimental Designs;experimental study;Gene Expression;Gene Expression Profile;Gene Expression Profiling;Genetic;genetic signature;Genetic Transcription;Glomerulonephritis;Heterogeneity;Histologic;Human;human disease;Immune;Immune Targeting;Immunoglobulins;Immunology;Immunosuppression;in vivo;Infiltration;Inflammation;Inflammation Mediators;Inflammatory;Innate Immune System;insight;intravital imaging;intravital microscopy;joint inflammation;K/BxN model;Kidney;Kidney Diseases;Kinetics;Ligands;Lupus;Macrophage;Malignant Neoplasms;Mediating;Mediator;Methods;migration;Modeling;Molecular;Monoclonal Antibodies;monocyte;multiplexed imaging;Mus;Myelogenous;Myeloid Cells;Natural Immunity;neutrophil;Neutrophil Activation;novel;Paralysed;Pathology;Pathway interactions;Penetration;Phagocytosis;Phase;Phenotype;Play;Positioning Attribute;prevent;Production;programmed cell death protein 1;programs;PTPRC gene;receptor;receptor expression;Receptor Signaling;Regulation;Resolution;Respiratory Burst;Role;Septic Shock;Signal Pathway;Signal Transduction;single-cell RNA sequencing;success;Suppressor-Effector T-Lymphocytes;T-Cell Activation;Therapeutic;therapeutic target;therapeutically effective;Tissues;transcription factor;transcriptome

PROJECT_TITLE: VISTA is a negative checkpoint regulator of innate immunity

STUDY_SECTION: HAI

STUDY_SECTION_NAME: Hypersensitivity, Autoimmune, and Immune-mediated Diseases Study Section[HAI]


NIH_SPENDING_CATS: Genetics;Neurodegenerative;Pediatric;Rare Diseases;Spinal Muscular Atrophy

ORG_CITY: COLD SPRING HARBOR

ORG_NAME: COLD SPRING HARBOR LABORATORY

PHR: Project Narrative RNA splicing is a fundamental step in normal gene expression, involving the precise removal of non-coding segments during the maturation of messenger RNA. Abnormal RNA splicing due to mutations in gene sequences that control the process, or to alterations in the splicing machinery, gives rise to a wide variety of diseases. By studying the fundamental mechanisms responsible for RNA-splicing specificity, and ways in which this process can be manipulated, the proposed research will facilitate the correct classification of mutations that affect splicing, and the design of more effective RNA-targeted therapeutics.

PI_NAMEs: KRAINER, ADRIAN R (contact)

PROGRAM_OFFICER_NAME: CZAPLINSKI, KEVIN

PROJECT_TERMS: 3' Splice Site;5' Splice Site;Abbreviations;Affect;Alternative Splicing;Antisense Oligonucleotides;Base Pairing;Binding;Biochemical;Biochemistry;Bioinformatics;Biological Assay;Biophysics;Blood - brain barrier anatomy;Cells;Cellular biology;Chromatin;chromatin immunoprecipitation;Classification;Complement;Complex;CRISPR screen;design;Disease;Epigenetic Process;Event;Excision;Exons;Familial Dysautonomia;Fluorescence;Funding;Gene Expression;Genes;Genetic Diseases;genetic disorder diagnosis;Genetic Enhancer Element;Genetic Transcription;Goals;Histone Deacetylase;Histone Deacetylase Inhibitor;Human;Human Genetics;Immunoprecipitation;improved;In Vitro;in vivo;Individual;insight;Introns;Knowledge;Label;Link;Maps;Mass Spectrum Analysis;Mediating;Messenger RNA;Methods;Minor;Molecular;mRNA Decay;mRNA Precursor;Mutation;Pharmaceutical Preparations;pharmacologic;premature;Process;Protein Isoforms;protein protein interaction;Protein Structure Initiative;Proteins;Proteomics;Recombinants;recruit;Regulation;Research;RNA;RNA Polymerase II;RNA Splicing;RNA-Binding Proteins;RNA-targeting therapy;Site;small molecule;Small Nuclear RNA;SMN2 gene;Specificity;Spinal Muscular Atrophy;Spliced Genes;Spliceosomes;Structural Models;synergism;Techniques;Terminator Codon;Testing;therapeutic development;U1 small nuclear RNA;Untranslated RNA;Valproic Acid

PROJECT_TITLE: Biochemistry of Pre-mRNA Splicing

STUDY_SECTION: MG

STUDY_SECTION_NAME: Molecular Genetics Study Section[MG]


ORG_DEPT: NEUROLOGY

PHR: Though Alzheimer’s disease was first described more than a century ago and the protein hallmarks (plaques and tangles) were identified decades ago, we now know that the proteins of both the plaques and tangles are composed of Aβ and tau prions, respectively. Being able to measure these two prions using rapid cultured cell bioassays in conjunction with transgenic rodent models, we are now able to attack many areas of Alzheimer’s disease research that were previously inaccessible. Structural transitions that feature in the transformation of the Aβ and tau proteins into prions can now be investigated at the atomic level as described in this application.

PI_NAMEs: PRUSINER, STANLEY B (contact)

PROJECT_TERMS: 7 year old;Adopted;age related;aging related disease;alpha helix;alpha synuclein;Alzheimer's Disease;Alzheimer's disease blood test;Alzheimer's disease brain;Amyloid;Amyloid beta-Protein;Animal Model;Animals;Apolipoprotein E;apolipoprotein E-3;apolipoprotein E-4;Area;Behavior;beta pleated sheet;Biochemical;Biological;Biological Assay;Biological Markers;Biological Process;Biology;Biophysics;Brain;brain tissue;Cadaver;Caring;Cell model;Cerebral Amyloid Angiopathy;Characteristics;Chemicals;Complex;conformational conversion;Creutzfeldt-Jakob Syndrome;Cryoelectron Microscopy;Cultured Cells;Data;data integration;demented;Disease;Disease Outcome;Down's Syndrome;Dura Mater;Ensure;Evolution;familial Alzheimer disease;Fiber;Fluorescence Microscopy;Genetic;Human;human embryonic stem cell;Iatrogenesis;improved;In Vitro;in vivo;Individual;Investigation;K-18 conjugate;Knock-in;Lead;Mass Spectrum Analysis;Measures;Membrane Proteins;Memory;Methodology;Modeling;Molecular;Molecular Biology;Molecular Conformation;Morphologic artifacts;mouse model;Multiple System Atrophy;Mutation;Neurodegenerative Disorders;Neurofibrillary Tangles;Neuropathogenesis;neurosurgery;novel;novel diagnostics;novel therapeutics;Pathogenesis;Pathology;Patients;Persons;Phenotype;Population;Prion Diseases;Prions;Procedures;Production;programs;Protein Conformation;Protein Isoforms;Proteins;Proteolysis;Proteomics;PrP;rapid technique;Recombinant Proteins;Research;Research Personnel;Resolution;Rodent Model;Roentgen Rays;Role;Route;Sampling;Senile Plaques;Signal Pathway;Signal Transduction;Somatotropin;Source;stem cell model;Structural Models;Structure;Synaptic plasticity;synthetic peptide;tau aggregation;tau Proteins;Techniques;Terminology;Testing;Therapeutic;trait;Transgenic Mice;Transgenic Organisms;transmission process;TREM2 gene;TYROBP gene;Ubiquitination;Validation;X-Ray Tomography;Yeasts

PROJECT_TITLE: Degenerative and Dementing Diseases of Aging


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative

PROJECT_TITLE: Core A: Administrative Core


ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Aging is often accompanied by cognitive deficits and is also the major risk factor for Alzheimer's disease (AD). This multi-component research program studies a rodent model of naturally occurring variation in cognitive aging, with the goal of understanding the neurobiological basis of impairment and preservation of brain function that could contribute to vulnerability and resilience, respectively, in AD. Building on existing therapeutic progress, work within this program will continue to contribute to the development of effective therapeutic interventions for cognitive decline in aging with potential for slowing late-onset AD progression in its earliest phases.

PI_NAMEs: GALLAGHER, MICHELA  (contact)

PROGRAM_OFFICER_NAME: WAGSTER, MOLLY V

PROJECT_TERMS: Achievement;Address;Affect;Age;age difference;age related;aged;Aging;aging brain;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease risk;animal old age;animal resource;Animals;Basic Science;Behavioral;Bioinformatics;Biological;Brain;Cells;Clinical;clinical investigation;Clinical Research;clinical translation;Cognition;Cognitive;Cognitive aging;cognitive capacity;Cognitive deficits;cognitive function;cognitive performance;cognitive testing;cohort;Coupled;data integration;data management;Dependence;Development;Disease Progression;entorhinal cortex;Episodic memory;Equilibrium;excitatory neuron;Exhibits;experience;Experimental Designs;experimental study;Failure;falls;Female;foot;gain of function;Goals;Hippocampal Formation;Hippocampus;Homeostasis;Human;human imaging;human old age (65+);Impaired cognition;Impairment;improved;in vivo imaging;Individual;Individual Differences;innovative technologies;insight;Interneurons;Intervention;Knowledge;Knowledge acquisition;Laboratory Animals;late life;Late Onset Alzheimer Disease;Lateral;Long-Evans Rats;loss of function;Macaca mulatta;male;Memory;Memory impairment;Methods;Mission;Modeling;multidisciplinary;neural;neurobehavioral;Neurobiology;Neurocognitive;normal aging;novel;Outcome;Parvalbumins;Pathway interactions;Performance;pharmacologic;Phase;Population;preservation;programs;Publications;Rattus;receptor;Research;Research Personnel;resilience;Risk;Rodent;Rodent Model;Role;Sex Differences;Site;slow potential;Statistical Data Interpretation;statistics;Stream;study population;Support System;Synapses;System;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;therapeutically effective;tool;Translating;translation to humans;Translations;Variant;Work;young adult

PROJECT_TITLE: Cognition & Hippocampal/Cortical Systems in Aging


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Brain Disorders;Dementia;Emerging Infectious Diseases;Infectious Diseases;Neurodegenerative;Neurosciences;Rare Diseases;Transmissible Spongiform Encephalopathy (TSE)

PI_NAMEs: SCHNIER, PAUL  (contact)

PROJECT_TERMS: abeta accumulation;aging related disease;alpha synuclein;Amyloid;Amyloid beta-Protein;biophysical analysis;biophysical properties;biophysical techniques;Biophysics;Brain;Cellular biology;Chemicals;Complement;crosslink;Cryoelectron Microscopy;Data;demented;Ensure;Escherichia coli;experience;Hydroxyl Radical;Image;Immunohistochemistry;In Vitro;in vivo;Label;laser capture microdissection;Lasers;Length;liquid chromatography mass spectrometry;mass spectrometric imaging;Mass Spectrum Analysis;Measures;Methodology;Methods;Molecular Conformation;Monitor;Mus;Neurofibrillary Tangles;peptide chemical synthesis;Peptides;Point Mutation;Preparation;Prions;Production;programs;Protein Analysis;Protein Footprinting;Protein Isoforms;Proteins;Proteomics;Reaction;Reagent;Recombinants;Resolution;Senile Plaques;Services;Site;solid state nuclear magnetic resonance;Solvents;Spatial Distribution;Spectroscopy, Fourier Transform Infrared;Structural Models;Surface Plasmon Resonance;tau aggregation;tau Proteins;Techniques;Technology;TREM2 gene

PROJECT_TITLE: Core B: Proteomics and Biophysics


NIH_SPENDING_CATS: Aging;Neurosciences

PROJECT_TERMS: Aging;animal data;animal old age;animal resource;Animals;Archives;blind;Cognition;Cognitive;Communication Methods;Communities;Consensus;Consultations;Data;data exchange;data management;data sharing;design;Documentation;Ensure;Evaluation Research;Event;Evolution;experimental study;Extramural Activities;Funding;Future;Goals;Group Meetings;Guidelines;Hippocampus;Individual;Institution;interest;Journals;Laboratories;Lead;Leadership;Maintenance;Manuscripts;meetings;member;Methods;Office of Administrative Management;operation;organizational structure;Play;Procedures;Process;Program Research Project Grants;programs;Progress Reports;Publications;Records;Research;Research Activity;Research Personnel;Resource Sharing;Resources;Role;Running;Sample Size;Sampling;Schedule;Statistical Data Interpretation;statistics;System;Tissues;United States National Institutes of Health;Update;Work

PROJECT_TITLE: CORE A-ADMINISTRATION


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biodefense and Related Countermeasures;Brain Disorders;Dementia;Emerging Infectious Diseases;Genetics;Infectious Diseases;Neurodegenerative;Neurosciences;Rare Diseases;Transmissible Spongiform Encephalopathy (TSE)

PI_NAMEs: CARLSON, GEORGE A. (contact)

PROJECT_TERMS: age effect;aged;aging related disease;Alleles;Alzheimer's Disease;Amyloid beta-Protein;animal care;Animal Experiments;animal facility;Animal Model;Animal Technicians;Animals;Apolipoprotein E;Biochemical;Biological Assay;Bioluminescence;biophysical analysis;Biophysics;Brain;Breeding;Caring;Cell Culture Techniques;Cellular Assay;Clinical;Coupled;Cryoelectron Microscopy;Cryopreservation;Data;demented;design;Development;Diagnosis;Disease;disease diagnosis;Disease Marker;Disease Progression;endonuclease;Environment;experimental study;Fingerprint;fluorescence imaging;Gene Modified;genetic risk factor;Genotype;Gliosis;Harvest;Human;human disease;in vitro Bioassay;in vivo;Incubated;Measurement;Mediating;Methodology;Microinjections;Modeling;Molecular Conformation;Monitor;Mus;mutant;Mutation;Neurodegenerative Disorders;novel;Onset of illness;overexpression;Pathologic;Patients;Peptides;prevent;Prion Diseases;Prions;Production;programs;Property;Proteins;Rattus;Research;Research Personnel;Resolution;Rodent;Rodent Model;Sampling;Services;Shapes;skills;Source;Structure;tau aggregation;tau Proteins;Tauopathies;Testing;Time;Tissue Banks;Transgenic Mice;Transgenic Model;Transgenic Organisms;transmission process;Validation

PROJECT_TITLE: Core C: Animals


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: MOUNTAIN HOME

ORG_NAME: JAMES H QUILLEN VA MEDICAL CENTER

PHR: NARRATIVE Patients with HIV infection often do not respond well to HBV vaccinations, and this phenomenon is also observed in other immunocompromised hosts, including the elderly, but the overall efforts to boost vaccine hypo- responsiveness in these subjects have been futile - in part due to our poor understanding of the underlying mechanisms that blunt vaccine responses. We have shown that chronic HIV or HCV infection can accelerate premature T cell aging due to telomere attrition - a hallmark of cellular senescence; however, the underlying mechanisms remain largely unknown. In this proposal, we will investigate how chronic HIV infection induces telomere attrition and T cell aging and how these molecular changes lead to HBV vaccine failure during HIV infection. This study will enhance our understanding of the fundamental mechanisms underlying immune aging in chronic viral infection and develop effective means to restore immune competence and improve vaccine efficacy in HIV-infected patients. It will also provide insight into common mechanisms of vaccine hypo- responsiveness under other immunocompromised conditions. It is thus clinically significant and timely.

PI_NAMEs: YAO, ZHI Q. (contact)

PROJECT_TERMS: Acceleration;Affect;Age;age related;Aging;aging biomarker;antiretroviral therapy;Apoptosis;booster vaccine;CD4 Positive T Lymphocytes;CDKN2A gene;Cell Aging;Cell Physiology;Cells;Chromosomes;Chronic;clinically significant;co-infection;Communicable Diseases;Disease;DNA;DNA Damage;DNA Repair Enzymes;DNA Sequence;DUSP6 protein;Elderly;Enzymes;exhaustion;Exhibits;Failure;Functional disorder;Genome Stability;Goals;growth arrest specific transcript 5;Hallmark Cell;Hepatitis B Infection;Hepatitis B Vaccination;Hepatitis B Vaccines;Hepatitis B Virus;Hepatitis C;Hepatitis C virus;HIV;HIV Infections;Homing;Immune;Immune response;Immunocompetence;Immunocompromised Host;Impairment;improved;Individual;Inflammatory;Influenza;insight;Lead;Length;Mediating;Messenger RNA;MicroRNAs;Modeling;Molecular;Morbidity - disease rate;mortality;novel;novel strategies;overexpression;Patients;Play;posttranscriptional;premature;preservation;prevent;prospective;protein function;Proteins;Public Health;recruit;response;Role;senescence;seroconversion;Streptococcus pneumoniae;success;superinfection;T cell response;T-Lymphocyte;TCR Activation;Telomerase;telomere;telomere loss;Telomere Maintenance;Telomere Shortening;TERF2 gene;Testing;translational study;Ubiquitin;Untranslated RNA;Vaccination;vaccine efficacy;vaccine failure;vaccine response;Vaccines;Veterans;Viral;Virus Diseases

PROJECT_TITLE: Telomere attrition and T cell aging in vaccine failure during HIV infection


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biodefense and Related Countermeasures;Biotechnology;Brain Disorders;Dementia;Down Syndrome;Emerging Infectious Diseases;Genetics;Infectious Diseases;Intellectual and Developmental Disabilities (IDD);Neurodegenerative;Neurosciences;Rare Diseases;Transmissible Spongiform Encephalopathy (TSE)

PROJECT_TERMS: 7 year old;Age;age effect;Age of Onset;aged;aging related disease;Alleles;alpha synuclein;Alzheimer's Disease;Alzheimer's disease blood test;Alzheimer's disease brain;Alzheimer's disease patient;Alzheimer's disease risk;Alzheimer's disease therapeutic;Amyloid beta-Protein;Animal Model;Apolipoprotein E;apolipoprotein E-4;Area;Astrocytes;Autopsy;Biological Assay;Blood;Brain;care costs;Caring;case control;Cell Line;Cell model;cell type;Cells;Cerebral Amyloid Angiopathy;Child;cognitive control;cohort;Collaborations;Collection;comorbidity;comparison control;Complement;Controlled Study;Cryoelectron Microscopy;Data;demented;Deposition;Disease;disease diagnosis;Disease Progression;Dissection;Down's Syndrome;Event;exosome;experimental study;Freezing;Funding;Gender;Genes;Genetic;genetic risk factor;Genetic study;genome sequencing;Genotype;Glial Fibrillary Acidic Protein;Gliosis;Human;human tissue;Impaired cognition;in vivo;Individual;Inherited;Investigation;Kinetics;Knock-in;Late Onset Alzheimer Disease;Length;Longevity;Luciferases;Measures;Medical;Methods;Modeling;Molecular;Molecular Conformation;Molecular Genetics;molecular modeling;Molecular Profiling;Monitor;Mosaicism;Mus;mutant;Mutation;Nerve Degeneration;neural;Neurodegenerative Disorders;Neurofibrillary Tangles;Neurons;neuropathology;non-demented;novel;Pathogenesis;Pathology;Patients;Persons;Phenotype;Prion Diseases;Prions;Protein Isoforms;Proteins;Proteomics;Protocols documentation;PrP;Publishing;racial diversity;Reporter;Reporting;Research;Rodent;Rodent Model;Role;Sampling;solid state nuclear magnetic resonance;Specimen;Surveys;synthetic peptide;System;tau aggregation;tau mutation;tau Proteins;Tauopathies;Testing;therapeutically effective;Time;tool;Transgenes;Transgenic Mice;Transgenic Organisms;whole genome;Work

PROJECT_TITLE: Project 1: Pathobiology and Genetics of Prions Causing Alzheimer's Disease


ORG_DEPT: CHEMISTRY

PHR: Project Narrative This project brings together the complementary expertise of two laboratories to tackle the challenges of developing a wide variety of organo- and metal-catalyzed amination reactions to prepare structurally diverse chiral amines. Olefins will be directly converted to enantiomerically enriched NH- and N-alkylaziridines via catalytically-generated N-electrophilic oxaziridines, ketimines and ketiminoesters will furnish fully-substituted amines upon catalytic asymmetric allylation, while arenes will be converted to the corresponding chiral and sterically hindered N-alkylanilines via catalytic C-H amination and using novel electrophilic aminating agents with previously inaccessible structural complexity. The resulting unprotected amine products are highly prized by the synthetic/medicinal chemistry communities and the new environmentally friendly chemical transformations (i.e., green chemistry) that emerge will expedite synthetic access to and reduce the production cost of highly functionalized nitrogen-containing materials and ultimately will lead to the faster development of new medicines.

PI_NAMEs: KURTI, LASZLO  (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TITLE: New catalytic methods for the rapid synthesis of N-unprotected chiral aziridines and amines

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-B(55)R]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: RIVERSIDE

ORG_NAME: UNIVERSITY OF CALIFORNIA RIVERSIDE

PHR: Project Narrative Alzheimer’s disease is the most common cause of dementia in the world and is projected to continue increasing in prevalence. This proposal will identify and characterize protein modifications in the brain that may be connected with the underlying causes of Alzheimer’s disease, potentially opening new options for treatment.

PI_NAMEs: JULIAN, RYAN ROY (contact)

PROGRAM_OFFICER_NAME: YANG, AUSTIN JYAN-YU

PROJECT_TERMS: Affect;age-related disease;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease pathology;Amino Acids;Amyloid beta-Protein;amyloid formation;Behavior;Biochemical;Brain;brain control;brain tissue;Cells;Chemicals;Chemistry;Crystalline Lens;Data;Dementia;Destinations;Digestion;Disease;Dissociation;Enzymes;epimerization;Event;Exhibits;experimental study;Failure;Genetic;Goals;Human;Hydrolase;Investigation;Investments;Isomerism;liquid chromatography mass spectrometry;Location;lysosomal proteins;Lysosomes;Maps;Mass Spectrum Analysis;Measures;Methods;Modeling;Modification;Mutate;Mutation;Neurofibrillary Tangles;novel therapeutic intervention;Pathogenicity;Pathology;Pathway interactions;Peptide Fragments;Peptide Hydrolases;Peptides;Persons;Positioning Attribute;Post-Translational Protein Processing;postmitotic;Prevalence;prevent;Protein Fragment;Proteins;Proteolysis;Recycling;Resources;Senile Plaques;Site;Structure;System;tau Proteins;Techniques;Technology;Testing;Tissue Sample;Variant

PROJECT_TITLE: Connecting long-lived protein isomerization to lysosomal failure in Alzheimer's disease

STUDY_SECTION: EBIT

STUDY_SECTION_NAME: Enabling Bioanalytical and Imaging Technologies Study Section[EBIT]


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

PROJECT_TERMS: age-related disease;aged;Aging;aging brain;aging population;Animal Husbandry;Animal Model;animal old age;animal resource;Animals;Archives;Autopsy;Award;Behavior assessment;behavior test;Behavioral;behavioral outcome;Biological;Blood specimen;Brain region;brain tissue;Cognition;Cognitive;cognitive function;cognitive neuroscience;cognitive performance;cohort;Coupled;Cues;Data;data archive;Data Files;data management;data sharing;demographics;disability;Dissection;DNA analysis;Documentation;Elderly;Electrophysiology (science);Episodic memory;Equipment and supply inventories;Exhibits;Female;Freezing;Fresh Tissue;Future;Genotype;Guidelines;Health;health record;Hippocampus;Human;human old age (65+);Impaired cognition;Impairment;In Vitro;in vivo evaluation;Individual;Individual Differences;late life;Learning;Long-Evans Rats;male;medial temporal lobe;Memory;Methods;Modeling;Neurobiology;Neurocognitive;Organ;Outcome;pathogen;Performance;Perfusion;Peripheral;Physiological;preservation;Procedures;programs;Protocols documentation;Rattus;Recording of previous events;Records;Reporting;reproductive;Research;Research Personnel;Research Project Grants;residence;Resource Sharing;Resources;Rodent;Sample Size;Sampling;Scientist;Severities;sex;Specimen;Standardization;statistics;study population;Supervision;System;Testing;Tissue Banks;tissue resource;Tissue Sample;Tissues;United States National Institutes of Health;Variant;Videotape;water maze;Whole-Cell Recordings;women subjects;Work;young adult

PROJECT_TITLE: CORE B-ANIMAL RESOURCE


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biodefense and Related Countermeasures;Brain Disorders;Dementia;Down Syndrome;Emerging Infectious Diseases;Infectious Diseases;Intellectual and Developmental Disabilities (IDD);Neurodegenerative;Neurosciences;Rare Diseases;Transmissible Spongiform Encephalopathy (TSE)

PI_NAMEs: DEGRADO, WILLIAM  (contact)

PROJECT_TERMS: abeta oligomer;aging related disease;Alleles;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease patient;Alzheimer's disease risk;Amyloid;Amyloid beta-Protein;amyloid structure;Animal Model;Animals;Apolipoprotein E;Binding;Biological Assay;Blood Vessels;Brain;Cell Culture Techniques;Cell Line;Cell model;Cells;Cerebral Amyloid Angiopathy;Characteristics;Clinical;Collaborations;Complex;crosslink;Cryoelectron Microscopy;demented;Development;Disease;Disease Progression;Down's Syndrome;Drug Screening;Environmental Risk Factor;Extracellular Domain;Fingerprint;Fluorescence Microscopy;Fluorescent Dyes;Genetic Diseases;genetic risk factor;Grain;Human;imaging agent;improved;In Vitro;in vivo;in vivo Model;Mass Spectrum Analysis;Membrane Proteins;Methods;Modeling;Molecular;Molecular Conformation;mouse model;Mus;mutant;Neurodegenerative Disorders;Neurons;neurotransmission;new therapeutic target;Patients;Prion Diseases;Prions;programs;Protein Isoforms;Proteins;Proteolysis;PrP;rapid technique;response;Risk Factors;Sampling;Senile Plaques;Signal Transduction;Slice;solid state nuclear magnetic resonance;Structural Models;Structure;Surface;System;tau conformation;tau Proteins;Tauopathies;Therapeutic Agents;Therapeutic Intervention;Tissue Sample;Tissues;Transgenic Mice;Transmembrane Domain;transmission process;TREM2 gene;TYROBP gene;Variant;With laterality

PROJECT_TITLE: Project 2: Conformation and propagation of misfolded forms of tau and Abeta


NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Congenital Heart Disease;Congenital Structural Anomalies;Genetics;Heart Disease;Infant Mortality;Pediatric;Prevention;Rare Diseases

ORG_CITY: ATLANTA

ORG_DEPT: BIOLOGY

ORG_NAME: GEORGIA INSTITUTE OF TECHNOLOGY

ORG_STATE: GA

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it investigates the genetic causes of one dangerous congenital heart disease. The identification of causal genes for the disease will not only lead to a better understanding of disease mechanisms but also shed light on the early diagnosis and intervention of the disease.

PI_NAMEs: JIA, SHU ;NIE, SHUYI  (contact)

PROGRAM_OFFICER_NAME: TOYAMA, REIKO

PROJECT_TERMS: Address;Anatomy;Animal Model;Animal Organ;Biological;Blood;Candidate Disease Gene;candidate identification;Cardiac Output;Cardiac Volume;cardiogenesis;causal variant;Cause of Death;Clustered Regularly Interspaced Short Palindromic Repeats;Color;Congenital Abnormality;congenital heart abnormality;Dangerousness;Detection;Development;Diameter;Disease;Double Outlet Right Ventricle;Early Diagnosis;Early Intervention;Elements;Embryo;Embryonic Heart;Etiology;Exhibits;experimental study;Foundations;Functional disorder;Gene Combinations;Genes;Genetic;Genetic Diseases;Genetic Models;Genetic Screening;Genetic study;Goals;Heart;heart function;Heart Research;human disease;Human Genetics;Hypoplastic Left Heart Syndrome;Image;Imaging Device;Imaging technology;Impairment;in vivo;Individual;Infant;Infant Mortality;innovation;Knowledge;Laser Scanning Microscopy;Lead;Left ventricular structure;lens;Light;malformation;Mediating;meter;Methodology;Methods;microCT;Microscope;Microscopy;millimeter;millisecond;Modeling;Molecular;Morphology;multi-photon;Mus;Mutate;Myocardial dysfunction;novel;Pathogenesis;Pathologic;Performance;Phenotype;Physiology;Population;Process;Public Health;Pump;Rana;Rapid screening;Research;Resolution;Role;Scanning;Scheme;Sensitivity and Specificity;Shortening Fraction;spatiotemporal;Specimen;Speed;structural heart disease;Structure;Study models;System;Tadpoles;Testing;Time;tool;transcription factor;Variant;Ventricular;Ventricular Septal Defects;Visualization;Work

PROJECT_TITLE: Functional screen for genetic causes of hypoplastic left heart syndrome

STUDY_SECTION: CDD

STUDY_SECTION_NAME: Cardiovascular Differentiation and Development Study Section[CDD]


PI_NAMEs: SOUTHWORTH, DANIEL RYLAND (contact)

PROJECT_TERMS: Acceleration;Address;Adopted;advanced disease;Affinity;aging related disease;Alzheimer's Disease;Amyloid;Amyloid beta-Protein;Amyloid Fibrils;amyloid formation;amyloid structure;Animal Model;Animals;Antibodies;beta pleated sheet;Binding;Biological Models;Brain;brain tissue;Cell Culture Techniques;Cells;chaperone machinery;Characteristics;Complex;crosslink;Cryoelectron Microscopy;Data;demented;Dementia;Derivation procedure;Disease;disease model;Disease Progression;disease-causing mutation;experience;Filament;Film;functional group;Future;genetic regulatory protein;Goals;graphene;Heat-Shock Proteins 70;Human;human tissue;In Vitro;in vivo;interest;K-18 conjugate;Length;Mediating;Methods;Modeling;Modification;Molecular;Molecular Chaperones;Molecular Conformation;Molecular Structure;mouse model;Mus;mutant;Mutation;Neurodegenerative Disorders;Neurofibrillary Tangles;new therapeutic target;novel therapeutic intervention;Nucleotides;Oxides;Pathologic;Peptides;pharmacologic;Population;prevent;Prions;Process;Protein Isoforms;Proteins;Quality Control;Regulation;Resolution;response;Senile Plaques;small molecule;Source;Structure;Surface;System;tau aggregation;tau Proteins;Technology;Therapeutic;Tissues;Toxic effect;ubiquitin-protein ligase;Ubiquitination;Variant;Work

PROJECT_TITLE: Project 3: Structural basis of amyloid formation and chaperone-mediated turnover


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Brain Disorders;Dementia;Neurodegenerative

PI_NAMEs: SALI, ANDREJ  (contact)

PROJECT_TERMS: 3-Dimensional;aging related disease;Amyloid beta-Protein;analytical ultracentrifugation;Architecture;Biophysics;Cells;Chemicals;Circular Dichroism Spectroscopy;Complex;Computer software;crosslink;Cryoelectron Microscopy;Data;Data Analytics;demented;Electron Microscopy;Environment;experimental study;Fluorescence;Fluorescence Microscopy;Goals;Grain;Human;Image;In Vitro;infrared spectroscopy;Length;Libraries;light scattering;Mass Spectrum Analysis;mechanical force;Membrane;Methods;Microscopy;Modeling;Molecular;Molecular Conformation;molecular mechanics;Molecular Sieve Chromatography;monomer;Mutation;Negative Staining;Nerve Degeneration;NMR Spectroscopy;Nucleotides;Optics;particle;Phenotype;Point Mutation;Prions;Process;protein complex;protein protein interaction;Proteins;Proteolysis;Protocols documentation;Rationalization;reconstruction;Resolution;restraint;Roentgen Rays;Sampling;Scheme;Shapes;Signal Pathway;Site-Directed Mutagenesis;solid state nuclear magnetic resonance;structural biology;Structural Models;Structure;Surface;System;tau aggregation;tau Proteins;Testing;Tomogram;Translating;TREM2 gene;TYROBP gene;X-Ray Tomography

PROJECT_TITLE: Project 4: Integrative structure modeling of protein complexes in aggregation


NIH_SPENDING_CATS: Kidney Disease;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Narrative Altered levels of FGF23, a bone-derived hormone necessary for regulating blood phosphate and vitamin D levels, is associated with several human diseases that affect bone development and bone health, as well as the integrity and the functioning of some other organs, such as the heart. We aim elucidating the mechanisms governing FGF23 production in bone, focusing on a mechanistic cellular pathway that has not been previously recognized to be involved in this important process. Our studies will likely aid in the generation of new and effective treatments for disorders caused or affected by altered FGF23 levels or activity.

PI_NAMEs: BASTEPE, MURAT  (contact)

PROGRAM_OFFICER_NAME: MALOZOWSKI, SAUL N

PROJECT_TERMS: Ablation;Acute Renal Failure with Renal Papillary Necrosis;Adenine;Affect;Biological Assay;Blood;bone;Bone Development;Bone Diseases;bone health;Cardiovascular system;Cell Line;Cells;Chronic Kidney Failure;Clinical Management;comparison control;Coupled;Diet;dietary;Dihydroxycholecalciferols;Disease;Disease Management;effective therapy;experimental study;Familial hypophosphatemic bone disease;Feedback;FGFR1 gene;fibroblast growth factor 23;Functional disorder;G-Protein-Coupled Receptors;Gene Expression Profiling;Generations;Genomics;Goals;GTP-Binding Proteins;Heart;Hormone secretion;Hormones;human disease;Impairment;improved;Inherited;Injections;inorganic phosphate;Ions;Kidney;Kidney Diseases;Kidney Failure;Knockout Mice;Knowledge;lysophosphatidic acid;Lysophosphatidic Acid Receptors;MAP Kinase Gene;MAPK3 gene;Mediating;Mediator;Metabolism;Minerals;Modeling;Molecular;mortality;mouse model;Mus;mutant;new therapeutic target;novel;Organ;Osteoblasts;Osteocytes;Outcome;Pathogenesis;Pathologic;Pathway interactions;Patients;Phenotype;Plasma;Play;Process;Production;promoter;Protein Kinase C;receptor;Regulation;response;Role;Serum;Side;Signal Pathway;Signal Transduction;skeletal;skeletal disorder;Testing;Tetradecanoylphorbol Acetate;Vitamin D;Vitamin D3 Receptor;Wild Type Mouse

PROJECT_TITLE: Skeletal FGF23 production mediated by GPCR/Gq/PKC signaling

STUDY_SECTION: SBDD

STUDY_SECTION_NAME: Skeletal Biology Development and Disease Study Section[SBDD]


PI_NAMEs: ZEGER, SCOTT L. (contact)

PROJECT_TERMS: Adopted;Age;Aging;analytical method;Animal Model;animal resource;archive data;Archives;Area;base;Behavioral;behavioral phenotyping;Bioinformatics;Cognition;Cognitive;Collaborations;Communication;complex data;Computers;Consultations;Data;Data Analyses;data archive;Data Collection;data management;Data Set;data sharing;Databases;design;Development;Documentation;experimental analysis;Experimental Designs;Funding;Goals;health record;Hippocampus;Human Resources;Individual Differences;Information Systems;large datasets;Libraries;Life;Link;Long-Evans Rats;meetings;member;Methodology;Methods;Micro Array Data;Modeling;Neurocognitive;new technology;Play;Postdoctoral Fellow;Preparation;Procedures;Process;programs;Publications;Rattus;Recording of previous events;Reliability of Results;Research;Research Design;Research Personnel;Resource Development;Resources;Role;Secure;Services;Standardization;Statistical Methods;statistics;Supervision;System;task analysis;Writing

PROJECT_TITLE: CORE C- DATA MANAGEMENT AND STATISTICS


NIH_SPENDING_CATS: Social Determinants of Health

ORG_NAME: HERBERT H. LEHMAN COLLEGE

PHR: RESEARCH NARRATIVE Underrepresented (UR) undergraduate students from Lehman College will participate in the Undergraduate Research Initiative for Scientific Enhancement (U-RISE) program. The Lehman U-RISE program has been designed to bring UR students into the STEM career pipeline and thus contribute to the diversity of the biomedical workforce in the US.

PI_NAMEs: DE LA PARRA, COLUMBA ;GALLEGO-DELGADO, JULIO ;MCGREGOR, DONNA  (contact)

PROGRAM_OFFICER_NAME: HARTON, MARIE DEBORAHGAYNELLE

PROJECT_TERMS: Academic support;Admission activity;African American;Biology;Biomedical Research;career;career development;Chemistry;cohort;college;Data;Degree Completion;Doctor of Philosophy;Education;Elements;Ethics;experience;Exposure to;Family;Female;Goals;Hispanic;Household;Low income;Mentors;Mission;Population;postgraduate education;programs;recruit;Reproducibility;Research;Science;skill acquisition;skills;Students;support network;Training;undergraduate student;Underrepresented Students

PROJECT_TITLE: U-RISE at Lehman College

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - D[TWD-D]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Clinical Research;Nutrition;Obesity

ORG_CITY: CLEMSON

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: CLEMSON UNIVERSITY

ORG_STATE: SC

PHR: Narrative Our ability to understand patterns in energy intake (EI), and to intervene on them to improve health, is limited by our inability to unobtrusively and reliably monitor EI in the context of daily life. We propose to investigate the use of smartwatch and smart ring devices to automatically detect intake gestures (“bites” of food, “drinks” of beverage) during mealtimes, and to evaluate the degree to which key demographic variables and contextual factors (e.g., dietary composition, food source) can be used in combination with intake gesture counts to reliably estimate EI. We will validate this sensor-based EI estimation approach across multiple settings (cafeteria, home, and free living) by comparing the sensor-based EI estimates to ground truth EI from video recordings (in cafeteria and home) and remote food photography (during free-living), and will implement the optimal validated approach via a free and publicly-available platform that guides researchers/clinicians in executing sensor-based EI self-monitoring protocols.

PI_NAMEs: GOLDSTEIN, STEPHANIE PAIGE;HOOVER, ADAM  (contact)

PROGRAM_OFFICER_NAME: EVANS, MARY

PROJECT_TERMS: Acceleration;Accounting;Address;Adult;Affect;Behavior;Behavioral;Beverages;Bite;Calories;Cellular Phone;Characteristics;Chronic Disease;Clinical;clinical application;contextual factors;cost;Data;Data Collection;design;Devices;Diet Records;dietary;Eating;Eating Behavior;Ecological momentary assessment;energy density;Energy Intake;Ensure;Etiology;Family;Fingers;Food;Gestures;Hand;Health;Health Benefit;Home;Household;Image;implementation barriers;improved;Individual;Informal Social Control;innovation;Intake;Intervention;Length;Life;Liquid substance;Location;mathematical model;Measurement;Measures;member;Methods;Modeling;Monitor;Morbidity - disease rate;mortality;Motion;Non-Insulin-Dependent Diabetes Mellitus;Obesity;obesity treatment;Oral cavity;Overweight;Participant;Patient Self-Report;Patients;Pattern;Performance;Photography;Play;precision nutrition;Prevention;Procedures;Protocols documentation;Public Health;Research;Research Personnel;Role;Rotation;Sampling;sensor;smart ring;smart watch;Source;Technology;Testing;Time;tool;Validation;validation studies;Video Recording;Work;Wrist;wrist motion

PROJECT_TITLE: Validating Sensor-based Approaches for Monitoring Eating Behavior and Energy Intake by Accounting for Real-World Factors that Impact Accuracy and Acceptability

STUDY_SECTION: LCBH

STUDY_SECTION_NAME: Lifestyle Change and Behavioral Health Study Section[LCBH]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

PI_NAMEs: KNIERIM, JAMES J (contact)

PROJECT_TERMS: age difference;age related;Age-associated memory impairment;aged;Aging;aging population;Alzheimer's Disease;Behavioral;Binding;Brain;Brain region;cell cortex;Cells;Code;Cognition;Cognitive;Conscious;Data;entorhinal cortex;Episodic memory;Event;experience;experimental study;Functional disorder;Head;Hippocampus;Hour;Individual;information processing;insight;Investigation;Lateral;Life;Location;Machine Learning;Medial;medial temporal lobe;member;Memory;Memory impairment;memory retention;Minor;neocortical;neural;Neurons;neuropathology;normal aging;Organism;Paper;Persons;Population;Prevalence;Property;Rattus;remote location;Research Personnel;Role;Signal Transduction;Smell Perception;sound;Speed;Stream;Structure;System;Techniques;Testing;Time;Validation;Vision

PROJECT_TITLE: PROJECT 1-Neural encoding based on lateral and medial entorhinal information processing streams in behaviorally-characterized aged rats


ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: Narrative The proposed program will provide support for postgraduate research training in the Department of Anesthesiology at McGovern Medical School as part of the University of Texas Health Science Center at Houston to qualified applicants who have committed to or are enrolled in postgraduate training in anesthesiology. The goal of this training is to provide the next generation of physician- scientists and researchers with the tools and training necessary for those who seek to improve medical care in areas relevant to perioperative care, palliative care, acute and chronic pain and health services delivery.

PI_NAMEs: ELTZSCHIG, HOLGER K. (contact);JU, CYNTHIA

PROGRAM_OFFICER_NAME: PAUL, MOUSHUMI

PROJECT_TITLE: Research Training of Anesthesiology Physician-Scientists


ORG_CITY: SAN JOSE

ORG_NAME: SAN JOSE STATE UNIVERSITY

PHR: PROJECT NARRATIVE The primary goal of the U-RISE program at San Jose State University is to improve the academic preparedness and research training in biomedical research for high performing undergraduate minority students. We have gained extensive experience in training URM students over the past 30 years and the U-RISE program will allow our highly dedicated research mentors to continue playing a pivotal role in this process. We ultimately intend to prepare our trainees to enter competitive Ph.D. or M.D./Ph.D. programs where they will be highly productive scientists who will not only help contribute to the improvements in human health for many years to come, but will also increase the diversity of the scientific workforce.

PI_NAMEs: OUVERNEY, CLEBER COSTA (contact);RASCON, ALBERTO A

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TERMS: CCL7 gene;Critical Thinking;Databases;Doctor of Philosophy;Educational workshop;Event;experience;Government;graduate school;Hispanic-serving Institution;Industry;Institution;Laboratories;Learning;Measurable;Mentors;Minority;Mission;National Institute of General Medical Sciences;Occupations;Outcome;Postdoctoral Fellow;posters;Preparation;programs;Recommendation;recruit;Reproducibility;Research;research faculty;Research Project Grants;Schools;Science;skills;student-centered approach;Students;summer program;summer research;symposium;Techniques;Training;Training Programs;Training Support;Underrepresented Students;Universities;web site;Work

PROJECT_TITLE: U-RISE Program at San Jose State University


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Breast Cancer;Cancer;Clinical Research;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Women's Health Research

ORG_CITY: COLLEGE PARK

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

PHR: Project Narrative-Relevance to Public Health We propose to develop a novel bioinspired 1-cell culture technology for isolating cancer stem cells (CSCs) that are capable of cross-tissue multilineage differentiation from cancer patients’ tumors, and to further utilize the CSCs for engineering 3D vascularized tumors using an innovative bottom-up strategy. This project may lay the foundation for creating novel high-fidelity CSC-based 3D tumor models to accelerate cancer drug discovery and for developing effective CSC-targeted therapies to combat cancer drug resistance-induced cancer recurrence and metastasis that are the main causes of mortality in cancer patients.

PI_NAMEs: HE, XIAOMING  (contact)

PROGRAM_OFFICER_NAME: BECKER, STEVEN

PROJECT_TERMS: 3-Dimensional;Acceleration;adipose derived stem cell;American;Animal Cancer Model;Animal Model;Antineoplastic Agents;Biocompatible Materials;Blood Vessels;Bone Marrow;Bone Marrow Stem Cell;Breast Cancer Cell;Breast Cancer Patient;cancer cell;cancer cell differentiation;cancer drug resistance;Cancer Etiology;Cancer Patient;cancer recurrence;cancer stem cell;cancer subtypes;carcinogenesis;Cardiac;Cause of Death;Cell Culture Techniques;Cell Line;Cell model;cell motility;Cell Separation;Cell Survival;cell type;Cells;Cellular Spheroids;Cessation of life;Chemotherapy-Oncologic Procedure;Chondrocytes;Collagen;Collecting Cell;combat;Complex;cost;Data;Devices;drug discovery;Drug Modelings;Drug resistance;Embryo;Encapsulated;Endothelial Cells;endothelial stem cell;Endothelium;engineered stem cells;Engineering;Epidermal Growth Factor Receptor;Failure;Fatty acid glycerol esters;Foundations;Frequencies;Gene Expression;hatching;Histology;Home;Human;Human body;human stem cells;Hydrogels;In Vitro;in vivo;Individual;innovation;Label;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Neoplasms;MDA MB 231;Methods;Microcapsules drug delivery system;Microfluidics;Modeling;mortality;Mus;nanolitre;Nature;Neoplasm Metastasis;Neoplasms in Vascular Tissue;neoplastic cell;neural;novel;novel anticancer drug;Nutrient;Organoids;Osteoblasts;osteogenic;ovarian neoplasm;Oxygen;Patients;Perfusion;Permeability;Play;Pluripotent Stem Cells;Proliferating;Property;Prostatic Neoplasms;protein expression;Public Health;rare cancer;Reporting;Role;scaffold;spheroids;stem cells;Stromal Cells;Study models;Surface;Suspension Culture;targeted treatment;Technology;Testing;three dimensional cell culture;three-dimensional modeling;Time;Tissues;Totipotent;triple-negative invasive breast carcinoma;tumor;Tumor Stem Cells;tumorigenesis;tumorigenic;Umbilical vein;Vascularization;Woman

PROJECT_TITLE: Multiscale hydrogel biomaterials-enabled 3D modeling of cancer drug resistance

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Clinical Research;Nutrition;Obesity;Prevention;Women's Health Research

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative Nearly half (46%) of US women diagnosed with breast cancer are overweight or obese and at an elevated risk for poor prognosis. The proposed research will improve the understanding of how energy imbalance affects breast cancer outcomes and the role of mTOR pathway activation as a targetable mediator in breast tumors, which will ultimately reveal novel strategies for improving clinical outcomes. The proposed research is in line with the part of NIH’s mission of developing fundamental knowledge that will contribute to reducing the burden of breast cancer.

PI_NAMEs: CHENG, TING-YUAN  (contact)

PROGRAM_OFFICER_NAME: SHELBURNE, NONNIEKAYE F

PROJECT_TERMS: Affect;angiogenesis;Behavior Therapy;Biological;Body mass index;Body Size;Body Weight decreased;breast cancer diagnosis;Cancer Prognosis;cancer recurrence;cancer subtypes;cell growth;Cessation of life;Clinical;Clinical Data;cohort;Data;Death Rate;Diabetes Mellitus;Diagnosis;Disease;Disease-Free Survival;energy balance;epidemiologic data;Estrogen receptor negative;Estrogen receptor positive;Estrogen Receptor Status;Exercise;FRAP1 gene;Gene Expression;Growth Factor;Immunohistochemistry;improved;inhibitor;innovation;Intervention;Knowledge;lifestyle intervention;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Gland Parenchyma;Mammary Neoplasms;Measures;Mediating;Mediation;Mediator;Metformin;Mission;mortality;Newly Diagnosed;novel strategies;novel therapeutic intervention;Obesity;Operative Surgical Procedures;Outcome;Overweight;Pathway interactions;Patient-Focused Outcomes;Patients;Phenotype;Phosphoproteins;Phosphorylation;Physical activity;Potential Energy;Prevention;primary outcome;Prognosis;Prospective, cohort study;protein expression;Recurrence;Recurrent tumor;Regulation;Research;Risk;Role;Second Primary Cancers;secondary outcome;Signal Pathway;Testing;Therapeutic;Tissue Sample;tumor;Tumor Tissue;United States National Institutes of Health;waist circumference;Waist-Hip Ratio;Weight;Woman;women's diagnosis

PROJECT_TITLE: Energy Balance, mTOR pathway signaling, and breast cancer prognosis

STUDY_SECTION: CHSB

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology B Study Section[CHSB]


PI_NAMEs: GALLAGHER, MICHELA  (contact)

PROJECT_TERMS: Achievement;Age;age effect;Age-associated memory impairment;age-related disease;aged;Aging;aging brain;Alzheimer's Disease;Alzheimer's disease risk;Anatomy;Award;Basic Science;Behavioral;Biological Markers;biomarker identification;Brain;Cell surface;Cells;Clinical;clinical application;Clinical Research;Cognition;Cognitive;cognitive function;Data;dentate gyrus;Dependence;Development;Disease;Dose;efficacy testing;Elderly;entorhinal cortex;Equilibrium;experimental study;Female;Funding;Funding Mechanisms;gain of function;gamma-Aminobutyric Acid;Hilar;Hippocampal Formation;Hippocampus;Human;Hyperactivity;Immunochemistry;Immunohistochemistry;immunoreactivity;Impairment;improved;In Situ Hybridization;Individual;Individual Differences;interest;Interneurons;Intervention;Label;late life;Late Onset Alzheimer Disease;Lead;Levetiracetam;loss of function;male;Measures;medial temporal lobe;Memory;Memory impairment;Memory Loss;memory process;Messenger RNA;Methodology;Methods;Modeling;Monkeys;Mus;nerve supply;neural;Neurobiology;Neurocognitive;Neurocognitive Deficit;neuroimaging;Neurons;Observational Study;Outcome;Output;Patients;Pattern;Phenotype;Population;pre-clinical;preservation;programs;Property;rabies label;Rattus;receptor;recruit;Regulation;Research;Research Project Grants;resilience;Risk;Role;sex;Side;Signal Transduction;Site;Somatostatin;study population;System;targeted agent;Testing;Therapeutic;Three-Dimensional Imaging;Tissues;tool;Tracer;Translating;translational potential;Treatment Efficacy;Work;young adult

PROJECT_TITLE: PROJECT 2-Network properties of entorhinal/dentate gyrus and CA3 region in behaviorally-characterized aged rats


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Dissemination and Implementation Research;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Mental Health;Prevention;Substance Misuse

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative Implementation science focuses on the translation of successful interventions into practice so that the people that need those interventions receive them. The Vietnam Implementation Science Advancement program will provide training to Vietnamese academic faculty, policymakers, program leaders, and students to develop HIV- related implementation science capacity. The program uses a depth and diffusion model to rapidly expand implementation science knowledge and skills in Vietnam.

PI_NAMEs: GO, VIVIAN F. (contact);LE, HUONG THI

PROGRAM_OFFICER_NAME: BANSAL, GEETHA PARTHASARATHY

PROJECT_TERMS: Academia;Address;AIDS prevention;Caring;Country;design;Diffuse;Diffusion;Doctor of Philosophy;Educational Curriculum;effective intervention;Evidence based intervention;Faculty;Fostering;Funding;Future;Goals;Grant;Health;Health Sciences;HIV;HIV Infections;Home;Immersion;implementation science;improved;innovation;Institution;Intervention;Intervention Studies;Knowledge;Manuscripts;Medical;member;Methods;Modeling;Persons;Pilot Projects;Policies;Policy Maker;programs;Public Health;Research;Research Personnel;research to practice;Research Training;routine practice;scale up;senior faculty;Series;skills training;Training;Training Programs;Translations;United States;United States National Institutes of Health;Universities;uptake;Vietnam;Vietnamese;virtual;webinar;Writing

PROJECT_TITLE: Vietnam Implementation Science Advancement: A Training Program to Improve HIV Prevention and Care


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Drug Abuse (NIDA only);Mental Health;Neurosciences;Pediatric;Physical Activity;Physical Injury - Accidents and Adverse Effects;Prevention;Social Determinants of Health;Substance Misuse;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE The ABCD Study consortium uses multimodal brain imaging, cognitive and clinical assessments, bioassays, mobile monitoring, and careful assessment of substance use, environment, psychopathological symptoms, and social functioning in 11,878 9-10 year-olds to be followed over 10 years, to determine the effects of substance use on adolescent brain and cognitive development. This ABCD Research Project Site will follow and assess participants enrolled in the study. These data will be shared with the scientific community to address a comprehensive range of questions concerning youth development.

PI_NAMEs: BARCH, DEANNA ;HEATH, ANDREW C.;MADDEN, PAMELA ANN (contact)

PROGRAM_OFFICER_NAME: DEEDS, BETHANY

PROJECT_TERMS: 10 year old;Address;Adolescence;Adolescent;adolescent substance use;Adult;adverse outcome;Affect;Age;Alcohol consumption;Alcohols;Anxiety;assessment application;Athletic Injuries;Behavior;Behavioral;Bioinformatics;Biological;Biological Assay;Biology;Brain;Brain imaging;Caffeine;Calendar;Cannabis;Child;Child Health;Childhood;Clinical assessments;Cognition;Cognitive;cognitive development;cognitive testing;cohort;college;Communities;Country;Data;Data Analyses;Decision Making;design;Development;emerging adult;Emotional;emotional factor;Enrollment;Ensure;Environment;Environmental Exposure;Environmental Risk Factor;Epidemiology;Ethics;Event;experience;Feeling suicidal;Female;follow-up;Funding;gene interaction;Genetic;Health;Impairment;Individual;Informatics;informatics infrastructure;Interview;Life;Link;Longitudinal Studies;marijuana use;Mental Depression;Mental disorders;Mental Health;Methodology;Methods;mobile application;mobile computing;Monitor;multimodality;neural;Neurocognition;Neurocognitive;neurodevelopment;neuroimaging;Neuropsychological Tests;novel;Occupations;Outcome;Parents;Participant;participant enrollment;participant retention;Pathway interactions;Persons;Physical activity;physical conditioning;Privatization;Process;Protocols documentation;Psychopathology;Qualifying;recruit;Recurrence;Registries;Research;research and development;Research Personnel;Research Project Grants;Resource Informatics;Resources;response;retention rate;Risk;Role;Sampling;Schools;Science;Secure;Severities;Siblings;Site;Sleep;sleep pattern;social;Social Functioning;Social isolation;social media;Specific qualifier value;Sports;Standardization;substance use;Symptoms;Technology;Teenagers;Telephone;temporal measurement;Text;Time;Tobacco;Tobacco use;Training;Traumatic Brain Injury;trend;Triplet Multiple Birth;tv watching;Twin Multiple Birth;United States;vaping;Video Games;young adult;Youth

PROJECT_TITLE: 21/21 ABCD-USA CONSORTIUM: RESEARCH PROJECT SITE AT WUSTL


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Breast Cancer;Cancer;Clinical Research;Comparative Effectiveness Research;Women's Health Research

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: NARRATIVE Breast cancer is the leading cause of cancer among women, with breast conserving surgery (BCS) often recommended as a standard treatment. Residual tumor left after BCS is a persistent concern due to its association with cancer recurrence, need for additional surgery, potential to cause patient anxiety, and risk for poor cosmetic outcomes. Here, we offer a new imaging strategy that can provide real-time feedback to the surgical team during the operation, as opposed to after the surgery has ended, to better guide breast tumor removal to reduce the need for additional surgeries and improve patient outcomes.

PI_NAMEs: FEREIDOUNI, FARZAD  (contact)

PROGRAM_OFFICER_NAME: DARDZINSKI, BERNARD JOSEPH

PROJECT_TERMS: Adipose tissue;Anxiety;Appearance;Area;Attention;Breast;Breast Cancer Treatment;Breast Diseases;breast imaging;breast lumpectomy;breast surgery;Breast-Conserving Surgery;Cancer Etiology;cancer recurrence;Carcinoma;Carcinoma in Situ;Caring;Clinical;clinical practice;Consumption;contrast enhanced;Cosmetics;cost;cost effective;Coupled;Diagnosis;diagnosis standard;Diagnostic;diagnostic accuracy;Diagnostic Imaging;diagnostic value;digital imaging;Engineering;Evaluation;Excision;experience;feasibility testing;Feedback;Fellowship;Fluorescence;Fresh Tissue;Frozen Sections;Glass;Goals;Health Care Costs;Healthcare;Healthcare Systems;Histology;Histopathology;Image;Image Enhancement;Image-Guided Surgery;imaging approach;imaging system;Imaging technology;improved;In Situ;instrumentation;Left;Lighting;Magnetic Resonance Imaging;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Gland Parenchyma;Mammary Neoplasms;Mastectomy;Measures;Mechanics;Methodology;Methods;microscopic imaging;Microscopy;Molecular;Morbidity - disease rate;novel;operation;Operative Surgical Procedures;Optics;Outcome;Pathologist;Pathology;Patient-Focused Outcomes;Patients;Postoperative Period;preservation;Procedures;Process;psychosocial;Publishing;Qualifying;Radiation therapy;Reader;Recommendation;recruit;Recurrence;Recurrent tumor;Repeat Surgery;Reporting;Residual Neoplasm;Residual state;Resolution;Risk;safety and feasibility;Scanning;Sectioning technique;Sensitivity and Specificity;Series;Slide;Specificity;Specimen;Speed;Stains;standard care;standard of care;Surface;Surgeon;Surgical margins;System;Techniques;Technology;Testing;Thinness;Time;Tissue imaging;tissue processing;Tissues;tool;Training;tumor;United States;validation studies;Woman

PROJECT_TITLE: GigaFIBI; rapid, large-format histology-resolution imaging for Intraoperative assessment of breast lumpectomy margins

STUDY_SECTION: IGIS

STUDY_SECTION_NAME: Imaging Guided Interventions and Surgery Study Section[IGIS]


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Cardiovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Mental Health;Physical Activity;Prevention;Sleep Research;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC

PHR: 8. Project Narrative Research to date has found inequities in cardiovascular disease and related health behaviors in the U.S. gender minority population. This study will be the first to determine the relationship between minority stress, resilience, mental health, and cardiovascular disease (CVD) risk factors (blood pressure, sleep and physical activity, tobacco use, and BMI) in a diverse sample of the U.S. gender minority population, using both self-report and objectively measured data. Findings will inform the development and testing of future intervention strategies aimed at reducing CVD risk and promoting the health and wellbeing of this and other vulnerable populations.

PI_NAMEs: BOCKTING, WALTER O. (contact);EDMONDSON, DONALD

PROGRAM_OFFICER_NAME: SMITH, SHARON M

PROJECT_TERMS: Acceleration;actigraphy;adequate sleep;Adolescence;Affect;Age;Behavioral;Behavioral Risk Factor Surveillance System;Biological Markers;Blood Pressure;Body mass index;Buffers;Cardiovascular Diseases;cardiovascular disorder risk;cisgender;Cities;cohort;Cohort Studies;Communities;coping;Coronary heart disease;Data;design;Development;Discrimination;disease disparity;Disparity;Ecological momentary assessment;Enrollment;ethnic minority;experience;Feminization;follow-up;Fostering;Funding;Future;Gender;gender affirmation;gender affirming hormones;gender expression;Gender Identity;gender minority;gender minority group;gender minority stress;Goals;harassment;Health;Health behavior;health care availability;health disparity populations;Health Promotion;Health Services Accessibility;Home;Hormones;Individual;Inequity;interest;Intervention;Interview;Knowledge;late life;life span;longitudinal design;Measurement;Measures;Medical;Mental Depression;Mental Health;minority stress;Modeling;Morbidity - disease rate;mortality;Myocardial Infarction;National Heart, Lung, and Blood Institute;New York City;nonbinary;Operative Surgical Procedures;Outcome;Patient Self-Report;Personal Satisfaction;Persons;Physical activity;physical conditioning;physical inactivity;Population;Prejudice;prevent;promote resilience;prospective;psychologic;psychological distress;racial minority;recruit;Reduce health disparities;Reporting;Research;Research Personnel;resilience;resilience factor;Risk;Risk Factors;Sampling;San Francisco;Sex Characteristics;sexual minority group;sexual minority health;Site;Sleep;Social support;Stress;Stroke;Structure;Testing;theories;Tobacco use;transfeminine;transgender;transmasculine;Variant;verbal;Vulnerable Populations;Work

PROJECT_TITLE: Impact of minority stress on cardiovascular disease risk and resilience

STUDY_SECTION: HDEP

STUDY_SECTION_NAME: Health Disparities and Equity Promotion Study Section[HDEP]


PI_NAMEs: KIRKWOOD, ALFREDO  (contact)

PROJECT_TERMS: Abeta synthesis;Ablation;Acceleration;Adult;Affect;Age;age related;age related changes;Age-associated memory impairment;aged;Aging;aging population;Alzheimer's Disease;Alzheimer's disease risk;AMPA Receptors;Area;Behavioral;Brain;Brain region;calmodulin-dependent protein kinase II;cell age;Cells;Cerebrospinal Fluid;Cognition;Cognitive;Cognitive aging;cognitive function;cognitive performance;comparative;Data;dentate gyrus;Deposition;Dominant-Negative Mutation;Elderly;entorhinal cortex;Equilibrium;excitatory neuron;experience;experimental study;Extracellular Protein;Functional disorder;functional status;Genetic;Hippocampus;Human;Hyperactivity;hyperphosphorylated tau;Impaired cognition;Impairment;Individual;Interneurons;Intervention;Lateral;Learning;medial temporal lobe;Mediating;Memory;Memory impairment;Modeling;mossy fiber;Mus;neural;neuronal pentraxin;Neurons;novel;optogenetics;Output;overexpression;Parvalbumins;Pathogenicity;Pathway interactions;Performance;Phase;Play;postsynaptic;preservation;Process;Production;programs;Pyramidal Cells;Rattus;recruit;Regulation;Research;Rodent;Rodent Model;Role;Sensory;sensory cortex;Simian virus 40;Structure;Synapses;synaptic function;System;Targeted Research;Testing;Theoretical Studies;therapeutic target;Toxic effect;Transfection;Viral;Virus;Whole-Cell Recordings

PROJECT_TITLE: PROJECT 3-Synaptic function in behaviorally-characterized aged rats in circuits of the entorhinal cortex and dentate gyrus


NIH_SPENDING_CATS: Aging;Genetics

ORG_CITY: HOUSTON

ORG_DEPT: GENETICS

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE  Various age-associated chromatin changes have been causally linked to aging. The cellular response to chromatin architectural defects (CAD response) is activated by chromatin stress and promotes longevity. This project will investigate the specific roles of CAD response in antagonizing age-associated chromatin changes and the mechanistic details on its regulation.

PI_NAMEs: DANG, WEIWEI  (contact)

PROGRAM_OFFICER_NAME: GUO, MAX

PROJECT_TERMS: Address;Affect;Age;age related;age related changes;age-related disease;aged;Aging;aging process;aging related;Architecture;biological adaptation to stress;Biological Models;cell age;Cells;Cellular Stress;Chromatin;Defect;DNA Transposable Elements;dosage;Elements;Euchromatin;Event;extend lifespan;gene function;Gene Silencing;Genes;Genetic;Genetic Transcription;Genome;Genomic approach;hallmarks of aging;Heat Stress;Heterochromatin;histone demethylase;histone modification;Histones;insight;Intervention;Knock-out;Lead;Link;Longevity;Longevity Pathway;Mediating;Metabolic;Metabolic Pathway;Micrococcal nuclease digestion of chromatin followed by sequencing;Modeling;Molecular;Molecular Conformation;Mothers;mutant;Names;novel;Nucleosomes;overexpression;oxidation;Oxidative Stress;Pathway interactions;Physiological;prevent;Regulation;Repetitive Sequence;response;Retrotransposition;Retrotransposon;Role;Series;Stress;Testing;Tissues;tool;transcription factor;transcriptomics;Yeasts

PROJECT_TITLE: Molecular mechanisms of cellular response to age-associated chromatin changes

STUDY_SECTION: CMAD

STUDY_SECTION_NAME: Cellular Mechanisms in Aging and Development Study Section[CMAD]