NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: WAITE, LINDA J (contact)

PROJECT_TERMS: Affect;Aging;Area;Behavior;Biological Sciences;career;Comprehensive Health Care;Demographic Factors;Discrimination;Doctor of Philosophy;Economic Factors;Economics;Ensure;Environment;Faculty;Funding;Funding Opportunities;Goals;Health;Health behavior and outcomes;health inequalities;Healthcare;healthy aging;Hospitalization;human old age (65+);Infrastructure;innovation;insight;Institution;Intervention;Intervention Studies;Investigation;Life;Link;Longitudinal Studies;Medicine;member;Mentorship;mid-career faculty;Mission;Monitor;mortality;Observational Study;older adult;Personal Satisfaction;Pharmacogenetics;Pilot Projects;Policies;population based;professor;Program Development;programs;Public Policy;Race;Research Methodology;Research Personnel;Research Support;Risk;Schools;skin color;social;social science research;Social Sciences;Sociology;timeline;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Program Development Core


ADMINISTERING_IC: AG

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Primary Health Care;Social Determinants of Health

ORG_CITY: CHICAGO

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PI_NAMEs: MELTZER, DAVID O (contact)

PROJECT_TERMS: Address;Affect;Aging;Amendment;Applications Grants;Area;Behavior;Caring;Clinical;Clinical Data;Clinical Research;Collaborations;Communities;Community Health Aides;Community Healthcare;Comprehensive Health Care;Data;Data Analyses;Data Collection;data harmonization;data resource;Data Sources;Demographer;Demography;Dental Care for Aged;design;Development;Disabled Persons;disadvantaged background;economic disparity;Economic Factors;Economics;Educational workshop;educationally disadvantaged;experience;Goals;Health;health care settings;Healthcare;Healthcare Systems;healthy aging;Hospitalization;hospitalization rates;innovation;interest;Intervention;Investigation;Life;Link;Longitudinal Studies;Medical;member;Modeling;novel;older adult;Outcome;outreach;patient engagement;Patients;pharmacogenetic testing;Physicians;Pilot Projects;Population;population based;programs;Research;Research Personnel;Resources;Risk;screening;social;social factors;Social Sciences;socioeconomic disadvantage;Surveys;Testing;theories;Underrepresented Minority;webinar;Work

PROJECT_TITLE: Innovative Network


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Bioengineering;Clinical Research

PI_NAMEs: CAGNEY, KATHLEEN A (contact)

PROJECT_TERMS: Adoption;Aging;aging demography;aging population;Area;Behavior;Brain;Calibration;Centers for Population Health;Chicago;Clinical;Cognition;Cognitive;Collaborations;Collection;Communities;Consent;cost;Cost Analysis;cost effective;Data;Data Collection;data integration;design;Development;dissemination strategy;Educational workshop;Ensure;experience;Family;Fostering;Funding;Future;Grant;Health;health data;health record;healthy aging;Hospitals;improved;Individual;innovation;interest;intergenerational;Internet;Investigation;Laboratories;Learning;Life Cycle Stages;Location;Measurement;Measures;meetings;member;Methods;Monitor;next generation;older adult;operation;Personal Satisfaction;Population;population based;Population Study;Process;Protocols documentation;Publications;Randomized;recruit;Research;Research Personnel;Resources;Respondent;Role;rural setting;Sampling;Series;Shapes;social media;success;summer institute;Surveys;symposium;Testing;Time;Training;Trust;Universities;webinar;Work

PROJECT_TITLE: Resources and Dissemination


ADMINISTERING_IC: MH

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Mental Health;Mental Illness;Neurosciences;Schizophrenia

ORG_CITY: ORANGEBURG

ORG_NAME: NATHAN S. KLINE INSTITUTE FOR PSYCH RES

ORG_STATE: NY

PHR: Mismatch negativity (MMN) is an auditory neurophysiological measure that correlates with the severity of cognitive impairment in schizophrenia. This project will develop animal models of MMN for use in early screening of novel therapeutic candidates for treatment of schizophrenia. .

PI_NAMEs: JAVITT, DANIEL C. (contact);NEYMOTIN, SAMUEL A;O'CONNELL, MONICA NOELLE;SEARS, ROBERT MILTON

PROGRAM_OFFICER_NAME: HUPALO, SOFIYA

PROJECT_TERMS: Acute;Address;Affect;Algorithms;analog;Animal Model;Animals;antagonist;Auditory;Auditory area;auditory processing;Back;Biological Assay;Biological Markers;Brain region;cell type;Cells;Chronic;Clinical;clinical investigation;Clinical Research;clinically relevant;Complex;Computer Models;CRISPR/Cas technology;Dendrites;density;Development;deviant;Disease;Distal;Drug Delivery Systems;drug development;early screening;Electrodes;Emotions;Equilibrium;Evaluation;Event-Related Potentials;Feedback;Frequencies;functional outcomes;Future;gamma-Aminobutyric Acid;Generations;Genes;genetic manipulation;Glean;Glutamates;Glycine;high risk;hippocampal pyramidal neuron;Homologous Gene;HTR2A gene;HTR3A gene;Human;human data;Impaired cognition;Impairment;in vivo;indexing;Individual;inducible Cre;Inferior frontal gyrus;information processing;insight;Interneurons;Intervention;Investigation;Ketamine;Location;Measures;Memory;Modeling;Molecular;Monkeys;N-Methyl-D-Aspartate Receptors;Nerve Degeneration;neurophysiology;neuropsychiatric disorder;nonhuman primate;novel;novel therapeutic intervention;novel therapeutics;outcome prediction;Pattern;Performance;pharmacokinetics and pharmacodynamics;Phase;phonology;Physiological;Population;pre-clinical;Pre-Clinical Model;preclinical development;prevent;Primates;Process;Program Development;Psilocybin;Psychoses;reading ability;receptor sensitivity;remediation;response;restoration;Rodent;Rodent Model;Role;Schizophrenia;Serine;Severities;Site;Somatostatin;Stimulus;Superior temporal gyrus;Surface;Testing;Thalamic structure;theories;therapeutic candidate;therapeutic development;therapy development;Theta Rhythm;Translating;translation to humans;Validation;verbal

PROJECT_TITLE: Auditory event-related potentials as in vivo preclinical assays of circuit engagement for E/I-based therapeutic development

STUDY_SECTION: PMDA

STUDY_SECTION_NAME: Pathophysiological Basis of Mental Disorders and Addictions Study Section[PMDA]


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Child Abuse and Neglect Research;Childhood Injury;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Opioid Misuse and Addiction;Opioids;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Physical Injury - Accidents and Adverse Effects;Prescription Drug Misuse;Prevention;Social Determinants of Health;Substance Misuse;Unintentional Childhood Injury;Violence Research;Youth Violence

ORG_CITY: NEW YORK

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: PROJECT NARRATIVE Early life adversity, including in utero and early childhood, may lead to lifelong physical and mental health, substance use, and behavioral problems. This longitudinal, population-based cohort study aims to elucidate the early and middle childhood health and healthcare outcomes of exposure to parental opioid use in early life. Results will shed light on the intergenerational effects of America's opioid crisis and inform the development of policies and early interventions for improving the wellbeing of children affected by parental opioid use.

PI_NAMEs: MEINHOFER, ANGELICA  (contact)

PROGRAM_OFFICER_NAME: HIGHSMITH, KEISHER S

PROJECT_TERMS: Accidents;Address;Adolescence;Adolescent Behavior;Adult;adverse childhood events;Affect;Age;Algorithms;Angelica;behavioral economics;behavioral health;Biostatistical Methods;Birth;care outcomes;career;Caring;Case Management;Cessation of life;Characteristics;Child;Child Care;Child Health;Child Health Services;child services;Child Welfare;Childhood;Chronic;clinical practice;Cohort Studies;Communicable Diseases;complex data;Country;Data;Data Linkages;data management;Data Set;design;Development;development policy;Domestic Violence;Drug usage;early childhood;Early Intervention;early life adversity;early life exposure;early onset;economic evaluation;Economics;Educational workshop;Epidemiologic Methods;Exhibits;experience;Exposure to;falls;Family;fetal;foster care;Foundations;Funding;Goals;Health;health care service utilization;health economics;Health system;heroin use;illicit opioid;Imprisonment;improved;in utero;indexing;Injury;Institutionalization;integrated care;Interdisciplinary Study;intergenerational;Knowledge;Knowledge acquisition;late life;Licensing;Life;Life Cycle Stages;Link;Literature;maltreatment;Medicaid;Mental disorders;Mental Health;Mentored Research Scientist Development Award;Mentors;Mentorship;Methods;middle childhood;Morbidity - disease rate;mortality;Mothers;multilevel analysis;Nature;Neonatal Abstinence Syndrome;neonatal health;Newborn Infant;offspring;Opioid;opioid epidemic;opioid exposure;opioid use;opioid use disorder;Outcome;Overdose;Parents;pediatric trauma;perinatal period;Pharmaceutical Preparations;physical conditioning;Poisoning;Policies;Policy Analysis;Policy Maker;population based;Population Study;Pregnancy;Pregnant Women;prenatal exposure;prescription opioid;prescription opioid misuse;Prevention;Problem behavior;Process;programs;Provider;Research;Research Design;Research Personnel;Residential Treatment;Resources;Sampling;Scoring Method;screening;Services;skill acquisition;socioeconomics;substance abuse treatment;substance use;Survival Analysis;System;theories;Time;Training;Training Activity;Transportation;Trauma;traumatic event;United States;Vulnerable Populations

PROJECT_TITLE: Intergenerational effects of America's opioid crisis: Parental drug use and offspring health

STUDY_SECTION: SSPA

STUDY_SECTION_NAME: Social Sciences and Population Studies A Study Section[SSPA]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Networking and Information Technology R&D (NITRD)

ORG_CITY: IRVINE

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

ORG_STATE: CA

PHR: Brief Narrative The skills needed for biomedical research are changing, thanks to a growing influence of “big” data. This program seeks to train the next generation of researchers in an interdisciplinary mode—blending biology with mathematics, computer science, engineering and physics—so that they can function effectively as scientists and educators in this new research environment.

PI_NAMEs: LANDER, ARTHUR D (contact);NIE, QING

PROGRAM_OFFICER_NAME: DAVANI, BEHROUS

PROJECT_TERMS: Computational Biology;Mathematical Biology;Systems Biology

PROJECT_TITLE: Mathematical, Computational and Systems Biology

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - B[TWD-B]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Emerging Infectious Diseases;Genetics;Infectious Diseases;Prevention;Tickborne Diseases;Vector-Borne Diseases

ORG_CITY: Los Alamos

ORG_NAME: TRIAD NATIONAL SECURITY, LLC

ORG_STATE: NM

PHR: The overarching hypothesis of this project is that reassortment of segmented viruses plays a major role not only to drive their diversification and evolution, but to dramatically alter their ecology and transmission dynamics. Specifically, we aim to 1) develop mathematical models of the intracellular life cycle for a family of segmented viruses to quantify for the first time their viral replication dynamics and reassortment frequencies, and 2) develop standardised sequencing protocols and novel phylogenetic methods to quantify the evolutionary and epidemiological implications of reassortment for Crimean-Congo hemorrhagic fever virus (CCHFV). A biobank with clinical and field samples from CCHFV endemic regions in Turkey and Tajikistan will be set up in this project. Clinical and field data will be leveraged to ensure our methods and results have the potential to inform public health strategies, predict outbreak risk and contribute to the One Health approach for the prevention and control of Crimean-Congo hemorrhagic fever disease.

PI_NAMEs: MOLINA-PARIS, CARMEN  (contact)

PROGRAM_OFFICER_NAME: ALARCON, RODOLFO M

PROJECT_TERMS: Acceleration;Address;Affect;Arthropods;biobank;Bunyaviridae;Cells;Clinical;Crimean Hemorrhagic Fever;Crimean-Congo Hemorrhagic Fever Virus;Data;Data Collection;Data Set;Disease;Ecology;Ensure;Epidemic;Epidemiology;Evolution;Family;Frequencies;Gene Expression;Genes;Genetic Enhancement;Genetic Recombination;Genomic Segment;Genotype;Health;Human;improved;In Vitro;Infection;Influenza A virus;Joints;laboratory experiment;Lassa;Life Cycle Stages;mathematical model;Meleagris gallopavo;Mentors;Methods;Modeling;novel;novel virus;Orthobunyavirus;Other Genetics;outbreak concern;outbreak prediction;pandemic disease;Phylogenetic Analysis;Phylogeny;Play;Point Mutation;Population;Postdoctoral Fellow;Prevention approach;Process;Protocols documentation;Public Health;public health emergency;Recording of previous events;Research;research and development;Research Personnel;RNA;Role;Sampling;Standardization;Tajikistan;Ticks;Time;transmission process;vector;Vertebrates;Viral Genes;viral transmission;Virion;Virus;Virus Replication;Work

PROJECT_TITLE: US-UK Collab: Modelling reassortment at the cellular, clinical, and phylogenetic level in emerging Bunyaviruses


NIH_SPENDING_CATS: Biotechnology;Digestive Diseases;Genetics;Immunization;Infectious Diseases;Pediatric;Vaccine Related

ORG_CITY: SAINT LOUIS

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative  Intraepithelial lymphocytes are a subset of T cells that reside in the host epithelium and play pivotal roles in barrier maintenance and protection. We propose to elucidate a novel function of small intestinal intraepithelial lymphocytes in the host defense against rotavirus, a major enteric viral pathogen in children. Our results will facilitate the rational design of novel therapeutics and vaccine design for enteric viruses, thereby reducing rotavirus infection-related diarrhea and mortality.

PI_NAMEs: DING, SIYUAN  (contact)

PROJECT_TERMS: Ablation;Anatomy;Animal Model;antagonist;Anti-viral Agents;Anti-viral Response;antiviral immunity;Aryl Hydrocarbon Receptor;Attenuated;Biological Assay;Biological Models;CD4 Positive T Lymphocytes;Cell Communication;Cells;Cellular biology;Cessation of life;chemokine;Child;Coculture Techniques;conditional knockout;Country;Cryoultramicrotomy;CX3CL1 gene;Data;design;Development;Diarrhea;Disease;Enteral;enteric infection;enteric virus infection;Enzyme-Linked Immunosorbent Assay;Epithelial Cells;Epithelium;Etiology;expectation;experimental study;Flow Cytometry;Foundations;functional outcomes;Gastrointestinal tract structure;Goals;gut inflammation;Host Defense;Hour;Human;Image;Immune Evasion;Immune signaling;Immunity;Immunofluorescence Immunologic;Immunologics;improved;in vivo;infancy;Infant Mortality;Infection;Inflammatory;innovation;intestinal epithelium;Intestines;intraepithelial;Knock-out;knockout gene;Knockout Mice;Knowledge;Life;LoxP-flanked allele;Lymphocyte;Lymphocyte Function;Lymphocyte Subset;Maintenance;Measures;Mediating;Mediator;Methods;monolayer;mortality;mouse model;Mucous Membrane;Mus;Neonatal;neonatal mice;Nonstructural Protein;novel;novel strategies;novel therapeutics;novel vaccines;old mice;Organoids;Outcome;pathogen;pathogenic virus;Pathologic;Play;Population;prevent;Primary Infection;Production;Publications;pup;rational design;Recombinants;recruit;Resolution;response;reverse genetics;Role;Rotavirus;Rotavirus Infections;Rotavirus Vaccines;Signal Pathway;single cell mRNA sequencing;single-cell RNA sequencing;Small Intestines;System;T-Cell Depletion;T-Lymphocyte Subsets;Testing;Therapeutic;Therapeutic Intervention;Transcript;vaccine candidate;Vaccine Design;vaccine efficacy;Validation;Viral;Viral Genome;Viral Pathogenesis;Viral Physiology;Virus;Virus Shedding

PROJECT_TITLE: Rotavirus interaction with gut intraepithelial lymphocytes

STUDY_SECTION: IHD

STUDY_SECTION_NAME: Immunity and Host Defense Study Section[IHD]


ORG_CITY: BALTIMORE

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative Exosomes are nanoscale vesicles circulating in our body, and the potential of exosome-based diagnosis and therapies has been widely recognized. However, we have limited information about how exosome generation is regulated and how its molecular contents are determined. In this Project, we will investigate the role of cellular metabolism in exosome biogenesis, which will deepen our understanding of exosomes and facilitate their use in clinical applications.

PI_NAMEs: JEONG, SANGMOO  (contact)

PROGRAM_OFFICER_NAME: SALVADOR MORALES, CAROLINA

PROJECT_TITLE: Metabolic regulation of exosome biogenesis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-M(55)R]


NIH_SPENDING_CATS: Antimicrobial Resistance;Bioengineering;Clinical Research;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Urologic Diseases

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative Antibiotic resistant bacteria already cause over 2.8 million illnesses and 35,000 deaths every year, with antibiotic misuse incurring up to $42 billion in avoidable costs per year in the US alone. Urinary tract infections (UTIs) in particular are the most common human bacterial infection accounting for 25-50% of antibiotic prescriptions with resistance rates among causative bacteria now exceeding 20% for commonly used antibiotics. The most important action to slow the spread of these resistant infections is improving antibiotic prescribing and stewardship, which this project seeks to improve through novel machine learning and data- driven methods to measure and predict effective antibiotic choices for urinary tract infections.

PI_NAMEs: CHEN, JONATHAN H. (contact)

PROGRAM_OFFICER_NAME: HUNTLEY, CLAYTON C

PROJECT_TERMS: Accounting;Adverse effects;Agreement;Antibiotic Resistance;Antibiotic susceptibility;Antibiotics;antimicrobial resistant infection;application programming interface;automated algorithm;Bacteria;Bacterial Antibiotic Resistance;Bacterial Infections;bacterial resistance;Bacteriuria;Centers for Disease Control and Prevention (U.S.);Cessation of life;Clinical;Clinical Data;clinical decision support;Clinical Decision Support Systems;Clinical Microbiology;Clinical Trials;Collaborations;Collection;combat;Combating Antibiotic Resistant Bacteria;Communities;Computers;Consultations;cost;Data;data harmonization;data sharing;data standards;Databases;Diagnostic;electronic data sharing;Electronic Health Record;electronic medical record system;Electronics;Evaluation;experience;FAIR principles;Feedback;Guidelines;Health;Health Care Costs;Hospitalization;Human;improved;Individual;Infection;innovation;Learning;Machine Learning;machine learning method;machine learning model;Manuals;Measures;Methods;microbial;model development;Modeling;Natural Language Processing;novel;Outcome Measure;Patients;Pattern;personalized predictions;Phenotype;phenotyping algorithm;point of care;predictive modeling;Predisposition;Process;prospective;Prospective Studies;prototype;Real-Time Systems;Recommendation;Reference Standards;Reproducibility;Research;Resistance;Risk;routine care;Selection Bias;Site;Specificity;statistical learning;statistics;Symptoms;Systems Integration;Test Result;Testing;Time;tool;Training;Translating;treatment risk;Urinary tract infection;Urine;Validation;Work

PROJECT_TITLE: Measuring and Predicting Appropriate Antibiotic Use to Combat Resistant Bacteria

STUDY_SECTION: CDMA

STUDY_SECTION_NAME: Clinical Data Management and Analysis Study Section[CDMA]


NIH_SPENDING_CATS: Antimicrobial Resistance;Clinical Research;Infectious Diseases;Rare Diseases

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PROJECT NARRATIVE A key step in the treatment of invasive bacterial infection is the selection of antibiotics that are capable of killing the causative pathogen. Yet, many patients fail to improve despite treatment with antibiotics that have proven in vitro activity against the invading bacteria. The objective of this proposal is to understand the bacterial and host factors underlying antibiotic failure during invasive Staphylococcus aureus infection of bone.

PI_NAMEs: CASSAT, JAMES E (contact)

PROJECT_TERMS: Acute;Address;Agglutinins;Antibiotic Therapy;antibiotic tolerance;Antibiotics;Automobile Driving;Bacteria;bacterial community;bacterial genetics;Bacterial Infections;Binding;Blood coagulation;bone;Cells;Characteristics;Childhood;Chronic;Clinical;Coagulase;Coagulation Process;cohort;combat;Communicable Diseases;Coupled;Data;Debridement;Detection;Disease;Endowment;Etiology;experience;experimental study;Exposure to;Failure;Fibrin;Fibrinogen;Freezing;Genes;genetic approach;genome-wide;Genus staphylococcus;Goals;Growth;Histologic;Human;Immune;Immune response;improved;improved outcome;In Situ;In Vitro;in vitro activity;in vivo;Infection;innovation;Integration Host Factors;Intervention;Invaded;Knowledge;Label;Link;Lipids;mass spectrometric imaging;Measures;Membrane Proteins;microbial;Microscopy;Modality;Modeling;molecular imaging;Morbidity - disease rate;mouse model;Mus;mutant;novel;novel strategies;novel therapeutic intervention;Operative Surgical Procedures;Osteomyelitis;pathogen;Pathogenesis;pathogenic bacteria;Patients;Pattern;pharmacologic;Phenotype;Physiological;Population;Positioning Attribute;Predisposition;Procedures;Process;Proteins;Prothrombin;Protocols documentation;Reagent;Reporter;Role;Sampling;Serum;small molecule;Specimen;Staphylococcus aureus;Staphylococcus aureus infection;Testing;Tissues;transposon sequencing;treatment duration;Treatment Efficacy;Treatment Failure;Virulence;Virulence Factors

PROJECT_TITLE: Mechanisms of antibiotic failure during osteomyelitis

STUDY_SECTION: SBSR

STUDY_SECTION_NAME: Skeletal Biology Structure and Regeneration Study Section[SBSR]


ORG_CITY: BOSTON

ORG_NAME: DANA-FARBER CANCER INST

ORG_STATE: MA

PHR: NARRATIVE  αβT lymphocytes recognize host cells that have been altered by infections or malignancies, and these vital lymphocytes are dependent upon force applied to their surface αβT cell receptors to tune recognition acuity. These forces arise from T cell motions locally (internally) or as T cells traffic through the host tissues (externally). By characterizing the biological and structural features of this force-dependent process, we shall be uniquely positioned to understand and ultimately manipulate T cell activation, fostering activation in patients with infectious diseases or cancers and inhibiting activation in patients with autoimmune disease.

PI_NAMEs: LANG, MATTHEW J.;REINHERZ, ELLIS L (contact)

PROGRAM_OFFICER_NAME: MALLIA, CONRAD M

PROJECT_TERMS: Acute;adaptive immunity;Affinity;Animals;Antibodies;Antigen-Presenting Cells;Antigens;Appearance;Autoimmune Diseases;Autoimmunity;Automobile Driving;B-Cell Antigen Receptor;Binding;Biological;Biological Assay;Biology;Biomechanics;biophysical analysis;biophysical properties;Biophysics;Blood;Cancerous;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Compartmentation;Cell Lineage;Cell Proliferation;Cells;Cellular biology;cellular pathology;cellular transduction;Chemicals;Communicable Diseases;comparative;conformer;Coupled;design;Development;digital;Discrimination;Effector Cell;empowerment;Engineering;Epithelium;Epitopes;experimental study;Fostering;hematopoietic stem cell differentiation;Immunity;immunodeficiency;in silico;In Vitro;in vivo;Individual;Infection;Infectious Agent;Influenza A virus;Kinetics;laser tweezer;Ligands;Ligation;Link;Lymphocyte;Malignant Neoplasms;Mature T-Lymphocyte;Measurement;mechanical force;mechanotransduction;Mediating;Memory;Methods;Minor;Modeling;molecular dynamics;Motion;Mus;next generation sequencing;optic tweezer;pathogen;Patients;Peptide Receptor;peptide structure;Peptides;Performance;Peripheral;Phase;Play;Population;Positioning Attribute;Process;Production;progenitor;Proteins;receptor;Receptor Cell;receptor function;Recombinant Proteins;Regulation;Relaxation;retroviral transduction;Role;secondary lymphoid organ;Sensitivity and Specificity;single cell analysis;single molecule;Somatic Mutation;Source;Specificity;stem cells;Structure;Structure of thymic medulla;Surface;System;T cell response;T memory cell;T-Cell Activation;T-Cell Development;T-Cell Receptor;T-Cell Receptor Genes;T-Lymphocyte;T-Lymphocyte Subsets;Techniques;Testing;thymocyte;Thymocyte Development;Thymus Gland;Tissue-Specific Gene Expression;Tissues;transcriptome;transcriptome sequencing;Variant;vector;Virus;X-Ray Crystallography

PROJECT_TITLE: Biology and structure of pMHC receptors functioning as mechanosensors in the [alpha][beta] T-cell lineage


PI_NAMEs: REINHERZ, ELLIS L (contact)

PROJECT_TERMS: Achievement;Adherence;Advisory Committees;Biology;Budgets;Cell Lineage;Collaborations;Communication;Data;data acquisition;data sharing;Electronic Mail;Ensure;Evaluation;Fostering;Goals;Grant;Group Meetings;Human Resources;Infrastructure;Institution;Intellectual Property;interest;Knowledge;Laboratories;Leadership;lectures;Logistics;member;Monitor;National Institute of Allergy and Infectious Disease;operation;Outcome;Peptide/MHC Complex;Principal Investigator;Process;Productivity;programs;Publications;receptor function;Reporting;Research Personnel;Resources;Series;Structure;symposium;T-Lymphocyte;Teleconferences;Time;timeline;Visit

PROJECT_TITLE: Administrative Core


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Eye Disease and Disorders of Vision;Genetics;Infectious Diseases;Neurosciences;Rare Diseases;Vector-Borne Diseases

ORG_CITY: SANTA BARBARA

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF CALIFORNIA SANTA BARBARA

PHR: Project narrative  The mosquito disease vector, Aedes aegypti, is troubling because it spreads viruses that cause diseases such as dengue, yellow fever, and Zika, which infect >100,000,000 people/year. The goals of the proposed research are to define members of two classes of receptors that mosquitoes use to find humans, clarify mechanisms through which they sense repellents, and to improve a promising approach for suppressing populations of Aedes aegypti. These studies could lead to the design of new traps, deterrent devices and genetic control strategies to reduce mosquito-borne disease.

PI_NAMEs: MONTELL, CRAIG  (contact)

PROGRAM_OFFICER_NAME: COSTERO-SAINT DENIS, ADRIANA

PROJECT_TERMS: Address;Aedes;Agriculture;Animals;Auditory;Behavior;Behavior Control;Behavioral;Behavioral Assay;Biological;Biological Assay;Blood;Bypass;Carbon Dioxide;Cells;Ceratitis capitata;Chemicals;Computer software;Consumption;Convection;Cues;Culicidae;Dangerousness;Data;deaf;Dengue;design;Detection;Development;Devices;Disease;Disease Vectors;Drosophila genus;egg;Electrophysiology (science);Elements;Environment;Esthesia;experimental study;Family;Female;G-Protein-Coupled Receptors;Genetic;genetic approach;genetic element;Glean;Goals;Hearing;Homing;Human;improved;in vivo;Infrared Rays;innovation;Insect Repellents;Insecta;insight;Light;male;Male Sterility;Mediating;member;Modeling;Molecular Genetics;Monitor;Mosquito Control;Mosquito-borne infectious disease;multimodality;Mutate;Mutation;Neurons;Odors;olfactory receptor;Opsin;Partner in relationship;Persons;Population;Population Control;prevent;Protein Isoforms;Proteins;receptor;Research;Rhodopsin;Role;sensor;Sensory;Sensory Receptors;Series;sex;Signaling Protein;Skin;Smell Perception;sterile insect technique;Sterility;Stimulus;success;Taste Perception;Techniques;Testing;tool;Transgenic Organisms;TRP channel;TRPA channel;viral transmission;Virus;Visual;Vitamin A;Work;Yellow Fever;ZIKA

PROJECT_TITLE: Opsins and TRP channels controlling sensation and behavior in Aedes aeygpti

STUDY_SECTION: NIC

STUDY_SECTION_NAME: Neuroscience of Interoception and Chemosensation Study Section[NIC]


NIH_SPENDING_CATS: Biotechnology

PI_NAMEs: MALLIS, ROBERT JOSEPH (contact)

PROJECT_TERMS: Amino Acids;Autoimmunity;Biological;Biology;Cell Lineage;Cells;Cellular biology;design;Development;DNA;DNA Repository;DNA Sequence;Endowment;Foundations;Future;Goals;Human Resources;Individual;Investigation;irradiation;Knowledge;Label;Length;Malignant - descriptor;Mammals;Mechanoreceptors;metaplastic cell transformation;Molecular;mutant;Mutate;pathogen;Peptide/MHC Complex;premalignant;Process;Production;programs;Property;Protein Engineering;Proteins;receptor function;repository;Resources;single molecule;Stable Isotope Labeling;Structure;T-Cell Receptor;T-Lymphocyte;Techniques;Technology;vector;Work;X-Ray Crystallography

PROJECT_TITLE: Protein Production


NIH_SPENDING_CATS: Bioengineering

PI_NAMEs: HWANG, WONMUK  (contact)

PROJECT_TERMS: Affect;Antigens;Behavior;Binding;Biology;Cell Lineage;Chimera organism;Collaborations;Comparative Study;Complex;Computer Simulation;Computer-Aided Design;Data;design;Development;Effectiveness;Entropy;Evolution;Exhibits;experience;experimental study;Feedback;Generations;Geometry;Goals;Individual;insight;laser tweezer;Link;Logistics;Major Histocompatibility Complex;Measurement;mechanical force;Mechanics;Methods;Modeling;Molecular Conformation;molecular dynamics;Monitor;Motion;mutant;next generation sequencing;novel;optic tweezer;Peptide Receptor;peptide structure;Peptides;Principal Component Analysis;Property;protein data bank;Protein Engineering;receptor function;Resources;response;Roentgen Rays;Role;Side;Signal Transduction;simulation;single molecule;Specific qualifier value;Specificity;Structural Models;Structure;supercomputer;Surface;System;T-Cell Receptor;T-cell receptor repertoire;T-Lymphocyte;Techniques;Testing;Time;transcriptome;transcriptome sequencing;Vertebral column

PROJECT_TITLE: Molecular Dynamics


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: PROJECT NARRATIVE & PUBLIC HEALTH RELEVANCE STATEMENT This high-impact application has critical ramifications for prostate cancer management and provides a paradigm-shifting diagnostic and therapy approach by exploiting the newly discovered biological function of PSMA, particularly for castrate resistant prostate cancer patients, who are in dire need of new therapy. The immediate impact will be the establishment of a new theragnostic paradigm for prostate cancer through inhibition of PSMA repurposing proven agents together with a ex vivo companion benchtop diagnostic assay.

PI_NAMEs: CARVER, BRETT STEWART;GRIMM, JAN  (contact)

PROGRAM_OFFICER_NAME: KONDAPAKA, SUDHIR B

PROJECT_TERMS: Androgen Antagonists;androgen independent prostate cancer;Androgens;Antigen Targeting;Automobile Driving;Biological;Biological Assay;Biological Process;Biology;Bioluminescence;Calcium;cancer diagnosis;Cancer Patient;cancer therapy;Carboxypeptidase;Castration;Central Nervous System Diseases;Combined Modality Therapy;Companions;Complex;Coupled;Diagnosis;Diagnostic;diagnostic assay;Diarrhea;Disease;FOLH1 gene;Folic Acid;FRAP1 gene;glutamatergic signaling;Glutamates;Growth;GTP-Binding Proteins;hormonal signals;hormone therapy;Hormones;Hyperglycemia;Hypotension;Image;Imaging Device;improved;inhibitor;innovation;J591 Monoclonal Antibody;kinase inhibitor;Luciferases;luciferin;Magnetic Resonance Imaging;Malignant neoplasm of prostate;Malignant Neoplasms;Measures;Metabotropic Glutamate Receptors;Monitor;Monoclonal Antibodies;Mus;Nausea;Neoplasm Metastasis;novel;novel therapeutic intervention;novel therapeutics;Oncogenic;Outcome;Patients;Penetration;personalized medicine;personalized therapeutic;Phosphatidylinositols;Phosphorylation;Phosphotransferases;PIK3CG gene;Positron-Emission Tomography;prevent;Prostate Cancer therapy;Prostatic;Proto-Oncogene Proteins c-akt;PSA level;public health relevance;Pulmonary Inflammation;Refractory;Resistance;response;Role;Safety;Sampling;serum PSA;Signal Pathway;Signal Transduction;Signaling Molecule;Source;standard care;success;System;Testing;Therapeutic Effect;Toxic effect;tumor;Tumor Burden;tumor growth;tumor progression;Urine;Vitamins;Work

PROJECT_TITLE: PSMA’s enzymatic activity as new target for Prostate Cancer diagnosis and therapy

STUDY_SECTION: IGIS

STUDY_SECTION_NAME: Imaging Guided Interventions and Surgery Study Section[IGIS]


NIH_SPENDING_CATS: Bioengineering;Nanotechnology

PI_NAMEs: LANG, MATTHEW J. (contact)

PROJECT_TERMS: acute infection;Adaptive Immune System;adaptive immunity;Address;alpha-beta T-Cell Receptor;Amino Acids;Antigen-Presenting Cells;Antigens;aspirate;Autoimmunity;Automobile Driving;Biological;Biological Assay;Biology;Biophysics;Calcium;CD8-Positive T-Lymphocytes;Cell Lineage;Cell surface;Cells;Cellular Assay;cellular pathology;Chemicals;Cognitive;comparative;computer studies;Couples;density;Development;Discrimination;DNA;Equilibrium;Exposure to;flu;Goals;Human;Immune response;Immunity;immunodeficiency;Immunologic Surveillance;In Vitro;in vivo;Individual;Infectious Agent;Influenza A virus;laser tweezer;Ligands;Light;Link;Maintenance;Maps;Measurement;Measures;Mechanics;mechanotransduction;Mediating;Memory;Modeling;Molecular;Molecular Conformation;molecular dynamics;Mus;Mutation;optic tweezer;Organism;Outcome;Output;pathogen;peptide structure;Peptides;Performance;Phase;Process;receptor function;Recovery;response;Sensitivity and Specificity;single molecule;Specificity;Structure;Surface;System;T cell response;T memory cell;T-Cell Activation;T-Cell Proliferation;T-Cell Receptor;T-Lymphocyte;Testing;thymocyte;tissue resident memory T cell;transcriptome;Work

PROJECT_TITLE: Mechanobiology of [alpha][beta]TCRs


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: ATLANTA

ORG_DEPT: PHARMACOLOGY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Narrative Epilepsy is a highly prevalent neurological disorder and it is frequently associated with psychiatric and neurologic comorbidities, such as difficulty with memory that degrade the quality of life. We have identified novel anti- inflammatory drug-like compounds that target the EP2 receptor, the major mediator of inflammation driven by cyclooxygenase 2, and validated proof-of-concept in cellular and animal models of epilepsy. We now propose to do additional lead-optimization studies to develop a preclinical candidate for advancement into IND enabling studies.

PI_NAMEs: GANESH, THOTA  (contact)

PROGRAM_OFFICER_NAME: CYWIN, CHARLES L

PROJECT_TERMS: Acute Disease;Address;Alzheimer's Disease;analog;Animal Model;antagonist;Anti-Inflammatory Agents;Anticonvulsants;aqueous;Biological Assay;Biological Availability;Blood - brain barrier anatomy;Brain;Canis familiaris;Cell Line;Cell model;Chronic Disease;clinical candidate;Cognition;Cognitive;Cognitive deficits;comorbidity;cyclooxygenase 2;CYP3A4 gene;Development;Dinoprostone;Disease Progression;Dose;Drug Kinetics;drug-like compound;efficacy evaluation;efficacy testing;Epilepsy;Extravasation;Fluorescence Resonance Energy Transfer;Formulation;glial activation;Gliosis;Goals;Histopathology;Hour;Human;immunoregulation;in vivo;Infiltration;Inflammation;Inflammation Mediators;Inflammatory;interest;Lead;lead optimization;Liquid substance;Mediating;Memory;Metabolism;Methods;Methylcellulose;Microglia;Migraine;Modeling;monocyte;Mus;Nervous System Disorder;neuroinflammation;Neurologic;neuron loss;Neuronal Injury;No-Observed-Adverse-Effect Level;nonhuman primate;novel;object recognition;Oral;Organ;Pathology;Penetration;Persons;Pharmaceutical Chemistry;Pharmaceutical Preparations;Phase;Phase I Clinical Trials;Phenotype;Plasma;post stroke;pre-clinical;Preclinical Testing;prevent;Preventive therapy;Preventive treatment;Property;Prostaglandin Receptor;Prostaglandins;Quality of life;Rattus;Reaction;receptor;Research;research clinical testing;Rodent;scaffold;scale up;Seizures;Signal Transduction;Solubility;Status Epilepticus;Sterility;Stomach;Structure-Activity Relationship;Suspensions;Testing;Therapeutic Agents;Therapeutic Index;tool;Toxic effect;Toxicokinetics;Water;WFDC2 gene

PROJECT_TITLE: Optimization of EP2 Antagonists for Post-Seizure Cognitive Deficits


NIH_SPENDING_CATS: Genetics

PROJECT_TERMS: adaptive immunity;Address;Autoimmunity;Behavior;Biology;Biomechanics;biophysical analysis;biophysical properties;CD3 Antigens;CD8B1 gene;Cell Lineage;Cells;Collaborations;combat;conformer;Core Protein;Data;Development;Discrimination;Elements;Event;Exhibits;experimental study;Fetal Thymic Organ Culture;Gene Rearrangement;Genes;Genetic Transcription;Human;Hydrophobicity;Immune;Immune response;In Vitro;in vivo;in vivo evaluation;Individual;laser tweezer;Ligands;Ligation;Lipids;mechanotransduction;Mediating;MHC Interaction;Molecular;Mus;Mutation;next generation sequencing;NMR Spectroscopy;notch protein;optic tweezer;pathogen;Peptide Receptor;peptide structure;Peptide/MHC Complex;Peptides;Population;Process;progenitor;Proliferating;receptor;receptor function;release of sequestered calcium ion into cytoplasm;Role;Signal Transduction;single molecule;Specific qualifier value;Specificity;Stromal Cells;Sulfoglycosphingolipids;Surface;System;T-Cell Receptor;T-Lymphocyte;TCR Activation;thymocyte;Thymocyte Development;Thymocyte Selection;Thymus Gland;transcriptome;transcriptome sequencing;X-Ray Crystallography

PROJECT_TITLE: Ligand-dependent preTCR function


PI_NAMEs: WAGNER, GERHARD  (contact)

PROJECT_TERMS: 3-Dimensional;adaptive immunity;Address;Adopted;Affect;Aromatic Amino Acids;Binding;Biology;Carbon;Cell Lineage;Cell Nucleus;Cell Physiology;Cell surface;Cells;Communities;Complex;Crowding;Cryoelectron Microscopy;Data;design;Detection;detection method;Development;Disease;dynamic system;Engineering;Escherichia coli;experimental study;Extracellular Domain;Feedback;forging;Goals;Histocompatibility;in silico;In Vitro;in vivo;in vivo evaluation;insight;Isotope Labeling;Label;Ligand Binding;Ligands;Ligation;Link;Measurement;Measures;Mechanoreceptors;mechanotransduction;Methods;Modeling;Molecular Conformation;molecular dynamics;Molecular Weight;Motion;Mus;mutant;Mutation;Nature;novel;Outcome;Pattern;Peptide Receptor;peptide structure;Peptides;Population;Procedures;programs;Property;Proteins;Pyruvate;receptor;Receptor Activation;receptor function;Recombinants;Relaxation;Resolution;restraint;Retinal blind spot;Scheme;Side;Signal Transduction;simulation;single molecule;Site;Source;Stable Isotope Labeling;Structure;Surface;synergism;System;T cell response;T-Cell Receptor;T-Lymphocyte;Techniques;Technology;Tertiary Protein Structure;Time;tool;Variant;Vertebral column;X-Ray Crystallography

PROJECT_TITLE: NMR Methods to decipher the structural and dynamics aspects of TCR mechanobiology


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: OVERALL: PROJECT NARRATIVE We have identified six complex problems associated with Superfund chemical contaminants that have proven intractable to current methods, in consultation with the Center’s key stakeholders. Using biomedical and engineering approaches we aim to generate research findings that will help solve these problems in association with our community partners and US government and California stakeholders.

PI_NAMEs: SMITH, MARTYN T (contact)

PROGRAM_OFFICER_NAME: CARLIN, DANIELLE J

PROJECT_TERMS: Address;Arsenic;Basic Science;Biological;biological systems;Biometry;Birth;California;Chemical Exposure;Chemicals;Child;Chromium;Collaborations;Communities;community based participatory research;community engagement;community partners;Complementary therapies;Complex;Consultations;Data;data sharing;design;drinking water;early life exposure;Education;Engineering;Ensure;Environment;Environmental Engineering technology;Environmental Health;environmental justice;environmental toxicology;Evaluation;Exposure to;Face;Fetus;Fostering;Goals;Government;Growth;Guidelines;halogenation;Hazardous Waste Sites;Health;Immune system;improved;In Situ;Infrastructure;innovation;Knowledge;Laws;Learning;Location;Mentorship;Metals;Methods;Mothers;neighborhood disadvantage;novel;Outcome;perinatal outcomes;Pesticides;Poison;Policies;pollutant;Poly-fluoroalkyl substances;Pregnant Women;prenatal influence;Problem Solving;Process;programs;Public Health;Regulation;remediation;Research;Research Ethics;Resistance;Resources;Risk Assessment;Site;Soil;success;Superfund;superfund chemical;System;Technology Transfer;Time;tool;Toxic effect;Toxicology;Training;translational engagement;vaccine-induced immunity;Water;Water Pollutants;water quality;Work

PROJECT_TITLE: Toxic substances in the environment


NIH_SPENDING_CATS: Clinical Research;Endocrine Disruptors;Foodborne Illness;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention;Rural Health;Social Determinants of Health

PHR: PROJECT 1: PROJECT NARRATIVE Project 1 will apply innovative scientific methods and a community-based research approach to characterize the presence of multiple regulated and unregulated/unmonitored drinking water contaminants, and advance understanding about the perinatal health effects of drinking water contaminant mixtures in some of California’s most vulnerable communities. Knowledge generated from this work, including the effects of drinking water exposures on birth outcomes, tap water sampling results for contaminants of current and emerging health concern such as PFAS, nitrate, arsenic, and hexavalent chromium, will benefit affected communities through novel and ethical report-back to participants, communities, and agency decision-makers that informs public health strategies and elucidates solutions to prevent and reduce harmful drinking water exposures among community water system and domestic well users in California.

PI_NAMEs: MORELLO-FROSCH, RACHEL ADELE (contact)

PROJECT_TERMS: Address;Affect;agricultural activity;Agriculture;Area;Arsenic;Back;Birth;Birth Records;Birth Weight;California;carcinogenicity;Carcinogens;Characteristics;Chemical Exposure;Chemicals;chromium hexavalent ion;Collaborations;Communities;community based participatory research;community based research;community engaged research;computational toxicology;County;Data;Databases;Detection;Development;developmental toxicity;Devices;digital;digital tool;drinking water;Endocrine disruption;Endocrine Disruptors;Environment;Environmental Health;environmental justice;Equity;Ethics;Exposure to;falls;fetal;Fetal Growth;Filtration;Frequencies;Gas Chromatography;Gestational Age;ground water;Hazard Assessment;Hazardous Chemicals;Health;Household;Individual;Industrialization;innovation;Interdisciplinary Study;Justice;Knowledge;landfill;Latino;Latinx;Life;Link;Liquid Chromatography;Los Angeles;Machine Learning;Malignant Neoplasms;mammary;Maps;Mass Spectrum Analysis;Measurement;Measures;member;Methods;Military Personnel;Monitor;multidisciplinary;neighborhood disadvantage;Neighborhoods;Nitrates;novel;Outcome;Participant;perinatal health;Persons;Pesticides;Poison;Poly-fluoroalkyl substances;Premature Birth;prenatal exposure;prevent;Printing;Privatization;Production;Public Health;recruit;Regulation;Reporting;reproductive;Research;Resolution;Resources;Risk;Rural;Salinas Valley;Sampling;Sampling Studies;Science;screening;Selection Criteria;Services;Site;Source;Spanish/English;spatial integration;study population;Superfund;synergism;System;Techniques;Testing;Time;tool;toxicant;Training;Universities;vulnerable community;Water;Water Pollutants;water quality;water sampling;women's outcomes;Work

PROJECT_TITLE: Characterization of drinking water contaminants and perinatal health effects in disadvantaged communities


NIH_SPENDING_CATS: Biomedical Imaging;Biotechnology;Brain Disorders;Genetics;Human Genome;Mental Health;Mental Illness;Neurosciences;Pediatric;Psychosis;Schizophrenia;Serious Mental Illness

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE In contrast to growth charts for height and weight, there is no accepted reference standard to anchor measures of individual differences in brain anatomy from magnetic resonance imaging studies, which has hampered neurodevelopmental investigations of the psychosis spectrum. Leveraging a successful multi-site imaging consortium, this proposal will use recently validated computational approaches to generate brain chart models for a rich set of brain morphological features across neuroanatomical scales. These charts will be used to identify heritable brain profiles, in the form of developmental imaging phenotypes benchmarked by brain chart norms, that are associated with evolution of psychosis spectrum symptoms.

PI_NAMEs: ALEXANDER-BLOCH, AARON FELIX (contact)

PROGRAM_OFFICER_NAME: WIJTENBURG, SARAH ANDREA

PROJECT_TERMS: Acceleration;Adolescence;Adult;Age;age effect;Anatomy;Area;association cortex;Benchmarking;biobank;Brain;Brain imaging;brain magnetic resonance imaging;brain morphology;Brain region;Brain scan;case control;Case/Control Studies;Child health care;Clinical;cohort;Communities;Data;Data Set;Development;Developmental Gene;Diagnosis;Disease;Early identification;Evolution;follow-up;Follow-Up Studies;Foundations;functional genomics;Future;Genetic;Genetic study;genetic variant;Genome;genome wide association study;genome-wide analysis;Genomics;Genotype;Goals;gray matter;Growth;Height;Heritability;heritability pattern;high risk population;Image;image processing;imaging genetics;imaging study;Individual;Individual Differences;innovation;Investigation;life span;Link;longitudinal analysis;Magnetic Resonance Imaging;Maps;Measures;Modeling;MRI Scans;Nature;Neuroanatomy;Neurobiology;neurodevelopment;neuroimaging;neuroinformatics;Noise;novel;online resource;Participant;Pattern;Pediatric Research;Pediatrics;Pennsylvania;Phenotype;Philadelphia;Psychiatry;Psychoses;psychosis risk;Publishing;Quality Control;rate of change;Reference Standards;Reporting;Reproducibility;Research;research clinical testing;Research Personnel;Resolution;Resources;Risk;risk variant;Sample Size;Sampling;Scanning;Schizophrenia;Scientist;Sensory;Shapes;Side;Signal Transduction;Site;spectrograph;Surface;Symptoms;Synapses;Techniques;Testing;Thick;transcriptome;translational study;treatment stratification;trend;Twin Multiple Birth;Universities;Weight;Work;Youth

PROJECT_TITLE: Precision brain charts for imaging-genomics of schizophrenia and the psychosis spectrum

STUDY_SECTION: NMBH

STUDY_SECTION_NAME: Neurological, Mental and Behavioral Health Study Section[NMBH]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Endocrine Disruptors;Immunization;Infectious Diseases;Pediatric;Pregnancy;Prevention;Vaccine Related

PHR: PROJECT 2: NARRATIVE Childhood immunizations are a cornerstone of public health prevention with enormous health and societal benefits. This study will investigate if prenatal and early childhood exposure to metals and PFAS, two common environmental contaminants, influence the developing immune system and response to childhood immunizations. Findings from this study will inform public health prevention strategies and risk assessment of multiple contaminants.

PI_NAMEs: CARDENAS, ANDRES  (contact)

PROJECT_TERMS: 7 year old;Accounting;Address;Adult;Affect;Animal Model;Antibody Formation;Antibody Response;Antibody titer measurement;Arsenic;Attenuated;Biological Markers;Birth;Blood;Boston;Chemical Exposure;chemical reduction;Chemicals;Child;Childhood;clinically relevant;cohort;Cohort Studies;Complex;cytokine;Data;Data Science;Development;Diphtheria;Diphtheria Toxoid;Disease;DNA Methylation;Dose;early childhood;early life exposure;Environment;Environmental Exposure;Environmental Pollutants;epidemiology study;epigenome;exposed human population;Exposure to;fetal substance exposure;First Pregnancy Trimester;Genes;genome-wide;Goals;Guidelines;Hazardous Substances;Health;Human;Immune;Immune response;Immune system;Immunity;Immunization;Immunologic Markers;immunoregulation;immunotoxicity;Individual;Interleukin-10;Interleukin-13;Interleukin-6;Joints;Knowledge;Lead;Leukocytes;Life;Life Cycle Stages;lymphocyte proliferation;Measles;Measles-Mumps-Rubella Vaccine;Measures;Mediating;Mediator;Mercury;Metal exposure;Metals;Methodology;Methods;Methylation;Mothers;Mumps;novel;offspring;Pathway interactions;Pertussis;Plasma;Poison;Poly-fluoroalkyl substances;Population;postnatal;Predisposition;Pregnancy;prenatal;prenatal exposure;prenatal influence;Prevention;Prevention strategy;prospective;Public Health;recruit;Reporting;Research;response;Risk;Risk Assessment;Rubella;rubella antibodies;Rubella virus vaccine;S-Phase Fraction;Sampling;School-Age Population;Serology;Specimen;Systems Development;Testing;Tetanus;Tetanus Vaccine;TNF gene;Toxicology;Umbilical Cord Blood;Vaccination;vaccine-induced immunity;Vaccines;Water Pollutants

PROJECT_TITLE: Influence of Exposure to a Mixture of PFAS and Metals on the developing immune system


NIH_SPENDING_CATS: Biotechnology;Endocrine Disruptors

PHR: PROJECT 3: PROJECT NARRATIVE To remediate mixed contaminant sites including per- and polyfluorinated alkyl substances (PFAS) and other highly halogenated compounds, polychlorinated biphenyls (PCBs), polybrominated biphenyl ethers (PBDEs), and chlorinated solvents, we need new approaches that are selective and highly reactive. This project will apply molecular biology, protein engineering, and high-throughput assays to identify aerobic and anaerobic microbial enzymatic-radical systems that can treat multiple classes of pollutants.

PI_NAMEs: ALVAREZ-COHEN, LISA  (contact)

PROJECT_TERMS: Aerobic;analog;Benzene;Bioinformatics;Biological;Biological Response Modifier Therapy;biological systems;Bioremediations;Chemicals;Cobalamin;Communities;Complementary therapies;Complex;Coupled;Coupling;Dioxanes;drinking water;efficacy evaluation;Electron Transport;Engineering;Environment;Environmental Health;Environmental Protection;Enzymes;Food;Future;ground water;halogenation;high throughput screening;Human;In Situ;interest;Laccase;Lead;Mediator;Metabolic Biotransformation;microbial;microbial community;mineralization;Molecular Biology;Molecular Biology Techniques;Nature;novel;novel strategies;Oxidation-Reduction;perfluorooctane sulfonate;Poison;pollutant;Poly-fluoroalkyl substances;polybrominated diphenyl ether;Polychlorinated Biphenyls;Prevalence;Process;Protein Engineering;Reaction;receptor;remediation;Research;response;Risk;Role;S-Adenosylhomocysteine;S-Adenosylmethionine;Site;Solvents;Source;Superfund;superfund site;System;Technology;Testing;tool;Training;Treatment Step;Trichloroethylene;Xylene

PROJECT_TITLE: In situ destruction of halogenated Superfund contaminants with biological radical reactions


NIH_SPENDING_CATS: Endocrine Disruptors

PHR: PROJECT 4: PROJECT NARRATIVE We aim to develop new approaches to remediate highly halogenated and hydrophobic contaminants that are resistant to oxidation including hexachlorobenzene, hexabromobenzene, polychlorinated biphenyl (PCBs), polybrominated biphenyl ethers (PBDEs), per- and polyfluorinated alkyl substances, and chlorinated solvents. We will investigate new techniques that exploit novel radical species capable of dehalogenating recalcitrant contaminants, determine conditions that minimize the formation of toxic transformation products, and develop kinetic models that can be used by field engineers. We also will characterize the major transformation products produced during the treatment process and their environmental fate and potential for remediation.

PI_NAMEs: SEDLAK, DAVID L. (contact)

PROJECT_TERMS: acute toxicity;Address;Alcohols;Aldehydes;Ames Assay;aqueous;Biological Assay;Bioremediations;Carbon;Chemicals;Chronic;cold temperature;Collaborations;Community Health;Complex;Cysteine;dehalogenation;diphenyl;Dose;drinking water;Ecosystem;Engineering;Environment;estrogenic activity;Estrogens;Exhibits;experience;Film;Flushing;Glutathione;ground water;halogenation;Hazardous Waste Sites;Hexachlorobenzene;high throughput screening;Histidine;Hydrocarbons;Hydrogen Peroxide;Hydrophobicity;Hydroxyl Radical;In Situ;Ketones;kinetic model;liquid chromatography mass spectrometry;Lysine;Mass Fragmentography;Medial;Metabolic Biotransformation;Methods;Modeling;Mutagenicity Tests;novel;novel strategies;Nucleic Acids;organic acid;organic contaminant;Organic solvent product;Oxidants;oxidation;Oxidative Stress;Oxygen;parental monitoring;Permeability;Petroleum;Phase;Poison;pollutant;Poly-fluoroalkyl substances;polybrominated diphenyl ether;predictive modeling;Predisposition;Process;Production;Property;Pump;Reaction;Reducing Agents;remediation;Research;Resistance;Risk;Sampling;screening;Signal Recognition Particle;Site;Soil;Solid;Solvents;Source;Sulfate;Sulfhydryl Compounds;Superfund;superfund site;System;Techniques;Temperature;Testing;Toxic effect;Water Supply

PROJECT_TITLE: In situ destruction of halogenated Superfund contaminants with persulfate-generated radicals


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cardiovascular;Childhood Obesity;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Nutrition;Obesity;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: MINNEAPOLIS

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative The proposed study will identify causal environmental contributors as well as biological and behavioral mechanisms through which stressors introduced and exacerbated by the pandemic influence child obesity and cardiometabolic risk. Moreover, this study will uncover potentially modifiable factors that may alter risk trajectories to inform policy and guide clinical and community-based interventions to reverse these concerning trends and prevent further adverse health outcomes.

PI_NAMEs: KUNIN-BATSON, ALICIA S (contact)

PROGRAM_OFFICER_NAME: LINDER, BARBARA

PROJECT_TERMS: 14 year old;4 year old;Adult;Affect;African American;Age;Behavioral Mechanisms;biobehavior;Biological;Biological Markers;Body Composition;Body fat;Body mass index;Buffers;cardiometabolic risk;cardiometabolism;Cardiovascular system;Cell Aging;Child;Child Care;Child Health;Child Rearing;Childhood;Chronic;Clinical;cohort;Communities;community intervention;COVID-19;COVID-19 pandemic;COVID-19 pandemic effects;Data;Data Collection;Development;Economics;effective intervention;Energy Intake;Enrollment;ethnic diversity;Ethnic Origin;executive function;Exhibits;experience;food insecurity;future outbreak;Goals;Health;Health behavior;Heel;Hospitalization;Household;housing instability;Hydrocortisone;imprint;Inadequate Sleep Hygiene;Income;Inflammation;Inflammatory;Intervention;Job loss;Latino;Longitudinal cohort;Low income;Measures;Mediating;Mental Health;Metabolic;Neighborhoods;Neurosecretory Systems;Obesity;obesity in children;obesity risk;obesity treatment;Outcome;Overweight;Oxidative Stress;pandemic disease;pandemic impact;pandemic stressor;Parents;Pathway interactions;Physical activity;Policies;Population;population health;Prevalence;prevent;prospective;protective factors;psychosocial stressors;public health priorities;Race;racial diversity;Recording of previous events;Reducing diet;Research;resilience;Resources;response;Risk;risk mitigation;school disruption;Security;Self Efficacy;Social isolation;Social Network;Stress;stressor;Surveys;Time;trend;tv watching;Weight maintenance regimen;Youth

PROJECT_TITLE: The impact of COVID-19 pandemic-related stressors on childhood obesity and cardiometabolic risk

STUDY_SECTION: KNOD

STUDY_SECTION_NAME: Kidney, Nutrition, Obesity and Diabetes Study Section[KNOD]


NIH_SPENDING_CATS: Behavioral and Social Science;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Prevention;Social Determinants of Health

PHR: CORE A: PROJECT NARRATIVE The Administration Core (AC) will provide leadership and support to address complex challenges related to Superfund contaminants including: characterizing mixed and early-life exposures and perinatal health effects in disadvantaged communities; understanding interactions among mixed exposures at hazardous waste sites and in health impact assessment; and, developing novel methods for in situ remediation and remediation of persistent chemicals. Thus, the AC will ensure program relevance by responding to all four SRP mandates, and the needs of stakeholders—including those tasked with advancing California’s Human Right to Water Law—and the Research Translation Coordinator will provide timely information and tools (remediation technology, data and analytics) to stakeholders, end-users, communities, and organizations. Our proposed infrastructure and strategy will efficiently leverage the diverse expertise and resources of Center investigators, stakeholders and collaborators, to ensure improved public health and environmental protection through regulatory and policy change.

PROJECT_TERMS: Accounting;Address;analytical tool;Area;Businesses;California;Characteristics;Chemicals;Childhood;Collaborations;commercialization;Communication;Communication Tools;Communities;community engaged research;community engagement;community involvement;community organizations;Complex;cost;Data;Data Analyses;Data Science;Data Set;data sharing;data tools;diverse data;drinking water;early life exposure;Educational workshop;Engineering;Ensure;Environment;environmental justice;Environmental Protection;Epidemiology;Equity;Event;experience;Feedback;Fostering;Goals;Government;ground water;Hazard Identification;Hazardous Waste Sites;Health;health assessment;Health protection;Human Rights;improved;In Situ;Industry;Information Centers;Infrastructure;innovation;Intellectual Property;Interdisciplinary Study;interest;Internet;investigator-initiated translational research;Joints;Language;Laws;Lead;Leadership;Licensing;Lightning;meetings;Methods;Monitor;National Institute of Environmental Health Sciences;neighborhood disadvantage;novel;novel strategies;perinatal health;Poison;Policies;prenatal;Process;programs;Public Health;remediation;Reporting;Research;Research Personnel;Resistance;Resources;Signal Recognition Particle;Site;social media;Soil;Superfund;superfund chemical;synergism;Technology;Technology Transfer;Testing;tool;Toxicity Tests;Training;Translating;translational goal;Translational Research;Translations;Transportation;uptake;Water;webinar;Work


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurosciences;Opioids;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Rural Health;Social Determinants of Health;Substance Misuse;Women's Health Research

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Various adverse and protective environments may affect child development. The Healthy Brain and Child Development (HBCD) Consortium will follow 7,200 mothers and their children from 27 locations across the US from before birth to 10 years of age to better understand which harmful and protective environments exert the greatest impact on child development. The HBCD Study will inform public policy to improve the health and development of children across the nation.

PI_NAMEs: NEWMAN, SHARLENE D;NEWSOM, CASSANDRA R. (contact);PERALTA-CARCELEN, ADA MYRIAM;YERBY, LEA GEORGETTE

PROGRAM_OFFICER_NAME: PRABHAKAR, JANANI

PROJECT_TERMS: Academic Medical Centers;addiction;Address;Adolescence;Affect;Alabama;Alcohols;antenatal;Area;autism spectrum disorder;Award;Basic Science;Behavioral;behavioral health;biobank;Biological;biological systems;Birth;Black race;Brain;Brain imaging;Center for Translational Science Activities;Child;Child Development;Childhood;Clinic;Clinical;Clinical Research;clinical research site;Cognitive;cohort;Collaborations;Communities;County;Data;Data Collection;Databases;design;Development;Discipline of obstetrics;Drug Exposure;early experience;early life exposure;Electroencephalography;Emotional;emotional behavior;Endocrine system;Enrollment;Environment;Environmental Exposure;Environmental Risk Factor;Epigenetic Process;Evaluation;experience;Exposure to;follow-up;General Population;Genetic;Goals;Growth;Gynecology;Health;Helping to End Addiction Long-term;high risk;Home;illicit opioid;immune function;in utero;indexing;Individual;Individual Differences;Infant;Infant Development;International;Longitudinal cohort study;Longitudinal Studies;Marijuana;Maternal and Child Health;Maternal Health;Maternal-fetal medicine;Medicaid;Metabolic;Minority Groups;Mothers;Multicenter Neonatal Research Network;Multicenter Studies;multimodal data;National Institute of Child Health and Human Development;Neighborhood Health Center;neonatal exposure;neurodevelopment;Neurodevelopmental Disability;neuroimaging;Neurosecretory Systems;Nicotine;Normal Range;Opioid;opioid exposure;Outcome;Parent-Child Relations;participant enrollment;Perinatal;Population;Population Heterogeneity;Pregnancy;Pregnancy Trimesters;Pregnant Women;prenatal;Prenatal care;prenatal exposure;prescription opioid;Productivity;programs;prospective;Protocols documentation;Provider;Recording of previous events;recruit;Research;research study;Resources;response;Rivers;Rural;Rural Community;Rural Health;rural health clinic;Rural Minority;Rural Population;sample collection;Sampling;SARS-CoV-2 exposure;Scientist;Second Pregnancy Trimester;Site;Social Behavior;socioeconomics;Stimulant;Stress;Structure;substance use;Tobacco;Toxic Environmental Substances;Translational Research;treatment program;ultrasound;United States National Institutes of Health;Universities;Weaning;Well in self;Woman

PROJECT_TITLE: HEALthy Brain and Child Development Study at UAB and UA

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-D(51)R]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Precision Medicine;Prevention;Prostate Cancer;Urologic Diseases

ORG_CITY: SEATTLE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Relevance to public health This project will develop a nondestructive assay for prostate cancer prognostication based on quantitative histomorphometric analysis of 3D pathology datasets of prostate specimens (biopsies and surgical excisions). This project will demonstrate that computational 3D pathology is superior to computational 2D pathology (including existing clinical nomograms) for distinguishing between aggressive and indolent prostate cancers, and therefore has value for guiding treatment decisions by urologists and oncologists.

PI_NAMEs: LIU, JONATHAN T.C. (contact);MADABHUSHI, ANANT

PROGRAM_OFFICER_NAME: OSSANDON, MIGUEL

PROJECT_TERMS: 3-Dimensional;Adjuvant Therapy;Archives;Biochemical;Biological Assay;Biopsy;Biopsy Specimen;Bread;cancer imaging;Categories;cellular imaging;Classification;Clinic;Clinical;Clinical Management;clinical risk;Complex;Computer software;Computing Methodologies;curative treatments;Data;Data Set;Development;Diagnostic;Disease;Excision;feature extraction;Gene Expression Profiling;Generations;Genitourinary system;Glass;Gleason Grade for Prostate Cancer;Goals;Guidelines;Histology;Histopathology;Image;Imaging Device;improved;Indolent;innovation;instrumentation;Intuition;Light;Localized Disease;Magnetic Resonance Imaging;Malignant neoplasm of prostate;men;Methods;Microscope;Microscopic;Microscopy;Microtomy;Modeling;Molecular;Morphology;National Comprehensive Cancer Network;Neoplasm Metastasis;Nomograms;novel;Nuclear;Oncologist;Oncology;Operative Surgical Procedures;Optics;Outcome;Pathologist;Pathology;patient stratification;Patients;Pennsylvania;Performance;Phenotype;predictive marker;preservation;prognostic;prognostic assays;Prognostic Marker;prognostic value;prognostication;Prostate;prostate biopsy;prostate cancer risk;Prostate Cancer therapy;prostate surgery;Prostatectomy;prototype;Public Health;Radiation;Radical Prostatectomy;Recurrence;Recurrent disease;Resolution;Risk;Risk Assessment;risk stratification;Sampling;Serinus;Slide;Specimen;Structure;success;surgical risk;surveillance imaging;System;Technology;three dimensional structure;Three-dimensional analysis;Tissue Sample;Tissues;tool;Training;Universities;Urologist;Validation;validation studies;Visual;Washington;whole slide imaging

PROJECT_TITLE: Prostate cancer risk stratification via computational 3D pathology

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


NIH_SPENDING_CATS: Behavioral and Social Science;Foodborne Illness;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Rural Health;Social Determinants of Health

PHR: CORE B (CEC): PROJECT NARRATIVE The Community Engagement Core - Water Equity Science Shop (CEC-WESS) will expand its impactful work to address California’s water equity challenges by leveraging the biomedical and water quality engineering expertise of Berkeley’s Superfund Research Center to advance the priorities of community-based non- governmental organizations (NGOs) and agency stakeholders working to advance CA’s Human Right to Water law. We will build upon WESS member Community Water Center’s online Drinking Water Tool by integrating new data layers that identify multiple drinking water threats, create community-informed metrics of drinking water quality and accessibility among domestic well communities to track agency progress on Human Right to Water implementation, and develop digital tools and an online portal (“What’s In My Water?”) for water justice organizations to integrate and visualize water quality data from multiple sources, and domestic well users to interpret their water testing results and learn how to protect themselves from harmful contaminants.

PROJECT_TERMS: Address;advanced system;agricultural activity;agricultural community;agricultural pesticide;Agriculture;Animal Feed;Arsenic;Attention;Back;base;Benchmarking;California;candidate identification;Chemicals;Chromium;Collaborations;Communities;community academic partnership;community based participatory research;community engaged approach;community engagement;community organizations;dashboard;Data;Data Set;data tools;Databases;demographics;digital;digital tool;Disparity population;drinking water;Droughts;Economics;Educational workshop;empowerment;Engineering;Enrollment;Environment;Environmental Health;environmental justice;Equity;Exposure to;Face;Failure;Goals;ground water;hazard;Hazard Assessment;Health;high risk;Household;Human Rights;improved;Individual;Industrialization;Inequity;Infrastructure;innovation;interactive visualization;Justice;Knowledge;landfill;Latino;Latinx;Laws;Learning;Los Angeles;Low income;Maps;marginalized community;meetings;member;Methods;Military Personnel;Monitor;multiple data sources;Needs Assessment;neighborhood disadvantage;Nitrates;Nongovernmental Organizations;novel;operation;Participant;Pesticides;Poison;Policies;Poly-fluoroalkyl substances;Population;Privatization;Process;programs;Registries;Reporting;Research;Research Ethics;Resources;Risk;Rural Community;Safety;Science;Services;social;social disparities;socioeconomic disadvantage;Sodium Chloride;Software Engineering;Source;success;Superfund;superfund site;System;Techniques;Test Result;tool;Toxic effect;Universities;Visualization;Visualization software;vulnerable community;Water;Water Pollutants;water quality;water sampling;Water Supply;water testing;web portal;web-based tool;well water;Work

PROJECT_TITLE: Community Engagement Core. Advancing California's Human Right to Water through the Water Equity Science Shop (WESS)


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: CLEVELAND

ORG_DEPT: PATHOLOGY

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative  ROLE OF SERPINB3 IN GLIOBLASTOMA CANCER STEM CELLS Glioblastoma (GBM) is the most common primary malignant brain tumor, and a population of cancer stem cells (CSCs) allows the tumor the tumor to quickly regrow after aggressive standard-of-care treatment. The objective of my project is to determine the mechanism through which GBM CSCs signal through junctional adhesion molecule-A (JAM-A) via Serpin B3, a serine/cysteine protease inhibitor that interacts with JAM-A and has been shown to signal through TGF-β in other cancers. The successful completion of this proposal will further our understanding of the signaling networks used by GBM CSCs for their self-renewal, identify new therapeutic targets and provide essential training toward my development as a physician scientist.

PI_NAMEs: LAUKO, ADAM  (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: Apoptosis;Attenuated;Binding;Biological Assay;Brain Neoplasms;cancer stem cell;career;Cell Death;Cell Maintenance;Cell Proliferation;Cells;chemotherapy;Chemotherapy and/or radiation;Co-Immunoprecipitations;Communication;crosslink;Cysteine Proteinase Inhibitors;Data;Development;disease prognostic;disuccinimidyl suberate;experience;Fellowship;Foundations;Future;Glioblastoma;Growth;Heterogeneity;Immunoprecipitation;In Vitro;Inhibition of Apoptosis;inhibitor;insight;Invaded;junctional adhesion molecule;knock-down;Laboratories;LIF gene;liquid chromatography mass spectrometry;Lysine;Lysosomes;Maintenance;Malignant neoplasm of brain;Malignant Neoplasms;Mass Spectrum Analysis;meetings;Membrane;Mentorship;Molecular;mortality;nerve stem cell;neutralizing antibody;new therapeutic target;next generation;novel;Operative Surgical Procedures;Outcome;overexpression;Pathway interactions;Patients;Peptides;Pharmaceutical Preparations;Phenotype;Phosphorylation Site;Physicians;pluripotency;Population;Proliferating;protein expression;protein function;Protein Secretion;Proteins;Proto-Oncogene Proteins c-akt;Radiation therapy;Recombinants;Recurrence;Regulation;Reporting;Research;Resistance;Role;Scientist;self-renewal;Serine;Serpins;Signal Transduction;Site;standard of care;stem cell function;stem cell model;stem cell self renewal;stem cells;Testing;Therapeutic;therapeutic development;Therapeutic Intervention;therapy resistant;Training;transcription factor;Transforming Growth Factor beta;treatment response;tumor;tumor growth;tumor initiation;tumorigenic;Up-Regulation

PROJECT_TITLE: Role of SerpinB3 in glioblastoma cancer stem cells


NIH_SPENDING_CATS: Bioengineering;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

PHR: CORE C: PROJECT NARRATIVE The Data Management and Analysis (DMAC; Core C) will provide support across all projects and cores for all aspects of the Center data, including platforms for storing and sharing data, data quality control, implementing common data structures to make sure they correspond to relevant standards, consultations for design issues, oversee analyses with existing methodology and development of new methodologies for novel intersections of data and scientific questions not currently addressed. We will collaborate with project leaders to present searchable pre-analysis plans as well as shareable data constructed according FAIR standards (https://www.go- fair.org/fair-principles/). Critical to the success of the Center will be our close cooperation of Center researchers and the implementation of existing cutting-edge machine learning methodology, with the goal of translation of these new tools to the wider research community.

PI_NAMEs: HUBBARD, ALAN E (contact)

PROJECT_TERMS: Address;Algorithms;Analytical Chemistry;archive data;Area;bioinformatics tool;Biological;Biological Markers;Biological Process;Biometry;Birth;Chemical Exposure;Chemicals;Collaborations;Communities;Complex;complex data;computational platform;Computer software;Consultations;cost effective;Data;data access;Data Analyses;data archive;data framework;data management;Data Management Resources;data quality;Data Science;Data Set;data sharing;design;Development;Disease Outcome;drinking water;Educational workshop;Environment;Environmental Exposure;Exposure to;Faculty;FAIR principles;genomic data;Goals;Hazardous Waste Sites;Health;Heterogeneity;high dimensionality;High Performance Computing;high risk;Human;improved;Infrastructure;learning strategy;life history;Linux;machine learning method;Measurement;meetings;Metadata;Methodology;Methods;microbial community;microbial genomics;Modeling;multidimensional data;novel;open data;Outcome;Pattern;Poison;Postdoctoral Fellow;precision medicine;Process;program dissemination;programs;Proxy;Quality Control;remediation;Research;Research Personnel;resilience;Resources;Risk;Sample Size;Sampling;Secure;Security;semiparametric;Services;software development;Soil;Statistical Algorithm;Structure;Subgroup;success;System;Time;tool;tool development;Training Activity;translational goal;Water;Water Pollutants;wiki;Work

PROJECT_TITLE: Data Management and Analysis Core (DMAC)


NIH_SPENDING_CATS: Data Science;Social Determinants of Health

PHR: CORE D (RESEARCH EXPERIENCE AND TRAINING COORDINATION CORE): NARRATIVE Berkeley SRP Trainees are critical to achieving the goals related to the central theme of our Center: “Systems approach to address the complex problems associated with Superfund contaminants.” These complex problems require diverse perspectives and skills; cross-disciplinary knowledge and interdisciplinary research to provide relevant knowledge and tools to reduce contamination and adverse health effects; and communication and leadership skills to work in multidisciplinary teams and with diverse communities and stakeholders to effect regulatory and policy change. The Research Experience and Training Coordination Core (RETCC) will recruit Trainees from diverse backgrounds, provide a holistic training experience beyond each trainee’s main field of focus or expertise to increase trainee understanding and engagement, foster interdisciplinary skills and mindset, increase social and cultural awareness, and strengthen professional development and career skills to address current problems and prepare future leaders in environmental health science and engineering.

PI_NAMEs: MCHALE, CLIONA  (contact)

PROJECT_TERMS: Accounting;Address;Affect;Award;Awareness;Big Data;Biological;California;career;Career Exploration;Chemicals;Chemistry;Childhood;Collaborations;Communication;Communities;community engaged research;community engagement;Complex;computational toxicology;cost;Creativeness;Data Science;Development;Discipline;doctoral student;Education;Educational Curriculum;Educational workshop;Engineering;Environment;Environment and Public Health;Environmental Engineering technology;Environmental Health;environmental justice;Environmental Science;experience;externship;Faculty;Fellowship;Fostering;Future;Goals;graduate student;Hazardous Waste Sites;Health;Human Rights;In Situ;innovation;Institution;interdisciplinary collaboration;Interdisciplinary Study;International;Knowledge;Laws;Lead;Leadership;lens;Machine Learning;meetings;Mentors;Methods;Mission;multidisciplinary;National Institute of Environmental Health Sciences;nature center;neighborhood disadvantage;novel;outreach;peer;Perinatal;Personal Growth;Poison;Policies;Postdoctoral Fellow;prenatal;Preparation;Productivity;Professional Competence;programs;recruit;remediation;Research;Research Project Grants;Resistance;Resources;Risk Assessment;Role;Signal Recognition Particle;skills;social;Students;Superfund;System;Thinking;tool;Toxicology;Training;Training Activity;training project;translational engagement;Translational Research;virtual;Water;Work


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Social Determinants of Health;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: BLACKSBURG

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

ORG_STATE: VA

PHR: PROJECT NARRATIVE Tobacco taxes are widely used and demonstrably effective in decreasing tobacco use and attendant diseases; however, the impact of taxes is complicated by an evolving and complex tobacco marketplace. This project will examine the effects of four novel tax proposals on tobacco product purchasing, including specific examinations of how these proposals interact with tobacco-related socioeconomic disparities and regulation designed to limit the nicotine in conventional cigarettes. The findings of this project will inform tobacco regulation to reduce health inequities and improve overall public health.

PI_NAMEs: SHEFFER, CHRISTINE ELIZABETH;STEIN, JEFFREY SCOTT (contact)

PROGRAM_OFFICER_NAME: KAUFMAN, ANNETTE R

PROJECT_TERMS: Address;Affect;Age;Behavior;behavioral economics;Characteristics;Cigarette;Cigarette Smoker;cigarette smoking;cigarillos;combustible cigarette;Complex;Consumption;design;Disease;Disparity;Electronic Nicotine Delivery Systems;Entropy;Equity;experience;Experimental Models;Goals;Harm Reduction;Health;health disparity;health equity;health inequalities;Health Policy;health practice;improved;Information Dissemination;innovation;Laboratories;low nicotine content cigarette;low socioeconomic status;Marketing;Measures;Methodology;Methods;Modeling;Modified Risk Tobacco Product;Nicotine;novel;Outcome;outcome forecast;parity;Participant;Pattern;Policies;polytobacco;Price;prospective;Public Health;Readiness;recruit;Regulation;Research;Risk;Sampling;Science;sex;Smoker;Smoking;smoking cessation;socioeconomic disparity;Socioeconomic Status;socioeconomics;Taxes;Testing;Tobacco;tobacco abstinence;tobacco control;Tobacco Dependence;tobacco products;tobacco regulation;Tobacco use;tobacco user;Translations;United States Food and Drug Administration

PROJECT_TITLE: Experimental Tobacco Marketplace: Forecasting the Health Equity of Novel Tax Proposals

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-RPHB-J(02)]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Autoimmune Disease;Eye Disease and Disorders of Vision

ORG_CITY: Los Angeles

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: The autoimmune disease, Sjögren’s syndrome, affects almost 1% of the population, while one of its principal characteristics is a debilitating dry eye disease associated with inflammation of the tear-producing lacrimal gland. Our research links accumulation of a protease, cathepsin S, in the lacrimal gland and its subsequent altered transport between membranes in lacrimal gland acinar cells, to the development of Sjögren’s syndrome- associated dry eye. Here, we explore the mechanisms underlying the increased expression and altered membrane sorting of cathepsin S in Sjögren’s syndrome-associated dry eye, and test the effects of drugs targeting protein phosphatase 2A and PIKFYVE to reduce this disease in murine models.

PI_NAMEs: HAMM-ALVAREZ, SARAH F (contact)

PROGRAM_OFFICER_NAME: MCKIE, GEORGE ANN

PROJECT_TERMS: 1-Phosphatidylinositol 4-Kinase;Acinar Cell;Affect;Antigen Presentation;ANXA2 gene;Apical;Autoantigens;Autoimmune;Autoimmune Diseases;Automobile Driving;Autophagocytosis;carboxypeptidase C;Caspase;Cathepsins;Cell membrane;Characteristics;Clinical Trials;Complication;confocal imaging;Dendritic Cells;Development;diabetic;Diagnosis;Disease;Drug Targeting;Dry Eye Syndromes;efficacy evaluation;efficacy testing;Electron Microscopy;Electrons;enzyme activity;Epithelial Cells;Equilibrium;exosome;Eye;Eye diseases;eye dryness;Feedback;Fluorescence;Frequencies;improved;In Vitro;Inbred NOD Mice;Inflammation;Inflammatory;inhibitor;Injections;Interleukin-12;Knock-out;Lacrimal gland structure;late endosome;light microscopy;Link;Liquid substance;Major Histocompatibility Complex;male;MAP Kinase Gene;Measures;Mediating;Membrane;Messenger RNA;Microtubules;Minor;Modeling;mouse model;mRNA Stability;mRNA Translation;Multivesicular Body;Mus;Mutant Strains Mice;Non obese;novel;novel therapeutics;ocular surface;ocular surface disease;overexpression;p38 Mitogen Activated Protein Kinase;Pathology;Pathway interactions;Patients;Peptide Hydrolases;pharmacologic;Phosphoric Monoester Hydrolases;Phosphorylation;Population;Prevalence;Process;Protein Dephosphorylation;Protein phosphatase;Protein Secretion;Proteins;Regulation;Reporting;Research;Salivary Glands;Secretory Vesicles;Serum;Signal Transduction;Sjogren's Syndrome;small molecule;Sorting;Symptoms;System;systemic inflammatory response;tear proteins;Testing;Therapeutic Agents;therapeutic effectiveness;TIS11 protein;trafficking;Translations;transmission process

PROJECT_TITLE: Microtubule-based Transport in Lacrimal Gland Function

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Muscular Dystrophy;Rare Diseases;Regenerative Medicine

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

PHR: Project Narrative Fusion of myoblasts is an essential process for muscle development and regeneration. The goal of this project is to explore the mechanisms of myomaker and myomerger action during myoblast fusion and to understand their role during chronic disease. !

PI_NAMEs: MILLAY, DOUGLAS PAUL (contact)

PROGRAM_OFFICER_NAME: LINDHURST, MARJORIE JEAN

PROJECT_TERMS: Area;Biochemical;Biochemistry;Cell membrane;Cell Membrane Permeability;Cells;Cellular biology;Chronic;Chronic Disease;Data;design;Disease;Disease Progression;Ectopic Expression;Event;Exercise;experimental study;Fibroblasts;Generations;Genetic;Goals;improved;indexing;insight;Integral Membrane Protein;Investigation;Knowledge;Lipids;Mammalian Cell;mdx mouse;Membrane;Membrane Fusion;Membrane Lipids;Membrane Proteins;Molecular;mouse model;Muscle;Muscle Cells;Muscle Development;muscle physiology;muscle regeneration;Muscular Dystrophies;Myoblasts;myogenesis;Myopathy;Natural regeneration;novel;novel strategies;novel therapeutic intervention;Pathogenesis;Pathologic;Pathology;Permeability;Phase;Process;progenitor;protein function;Proteins;proteoliposomes;Reaction;reconstitution;Regenerative Medicine;risk mitigation;Role;Skeletal Muscle;Stress;System;Time;Transmembrane Domain;Work

PROJECT_TITLE: Deciphering mechanisms of myoblast fusion

STUDY_SECTION: SMEP

STUDY_SECTION_NAME: Skeletal Muscle and Exercise Physiology Study Section[SMEP]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Neurosciences

ORG_DEPT: PSYCHOLOGY

PHR: PROJECT NARRATIVE:  Emotion-regulatory failures are central to mood and anxiety disorders, which afflict over 20% of the adult population in the United States and are challenging to treat. Extant evidence implicates altered function of the lateral prefrontal cortex (LPFC) in these disorders, but the specific contributions of LPFC to adaptive emotion remain poorly understood. The proposed studies harness a combination of state-of-the-art brain imaging analyses and methods that permit causal inference to uncover the roles of distinct LPFC regions in emotional responding and regulation, thereby advancing the development of a model that can be applied to optimize treatment for individuals who suffer from mood and anxiety disorders associated with LPFC dysfunction.

PI_NAMEs: LAPATE, REGINA  (contact)

PROGRAM_OFFICER_NAME: BREEDEN, ANDREW LEE

PROJECT_TERMS: Adult;Advanced Development;Affect;Affective;Amygdaloid structure;Anatomy;Anxiety Disorders;Attenuated;Behavior;Brain imaging;Code;cognitive control;Complex;Data;Disease;emotion regulation;Emotional;emotional functioning;Emotions;Evaluation;Event;Failure;Functional disorder;Functional Magnetic Resonance Imaging;functional MRI scan;Goals;Human;imaging modality;Impairment;Incidence;Individual;innovation;insight;Lateral;Lesion;Major Depressive Disorder;Mental Depression;Mental Health;Modeling;Mood Disorders;Multivariate Analysis;National Institute of Mental Health;Neuroanatomy;Neurocognitive;novel;Personal Satisfaction;Population;Prefrontal Cortex;Process;Regulation;response;Role;Science;showing emotion;Signal Transduction;Specificity;Stimulus;Task Performances;Testing;Time;Transcranial magnetic stimulation;treatment optimization;United States;With laterality;Work

PROJECT_TITLE: Lateral prefrontal organization in emotion: representational and causal mechanisms

STUDY_SECTION: HCMF

STUDY_SECTION_NAME: Human Complex Mental Function Study Section[HCMF]


ED_INST_TYPE: UNIVERSITY-WIDE

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: PROJECT NARATIVE Our proposal aims to dissect the molecular mechanisms causing autoimmune thyroid disease (AITD). Our focus is on genetic mechanisms predisposing to AITD, as well as mechanisms engaged by environmental factors and medications causing AITD. These studies will identify molecular triggers of AITD that will hopefully help in the development of novel mechanism-based therapies for AITD.

PI_NAMEs: STEFAN-LIFSHITZ, MIHAELA ;TOMER, YARON  (contact)

PROGRAM_OFFICER_NAME: BURCH, HENRY B

PROJECT_TERMS: Acceleration;Adenovirus Vector;Alprostadil;anti-PD-L1;Apoptosis;Autoantigens;Autoimmune Diseases;Autoimmune Process;autoimmune thyroid disease;Autoimmunity;Autophagocytosis;Binding;Biological Assay;Biotin;Cathepsins;Cell Line;Cells;Co-Immunoprecipitations;Complementary DNA;Complex;cytokine;design;Development;Disease;Electron Microscopy;endoplasmic reticulum stress;Environmental Risk Factor;experience;Genes;Genetic;Goals;Graves' Disease;Hashimoto Disease;Hormones;Human;Immune;Immune checkpoint inhibitor;Immunization;immunogenic;immunogenicity;in vivo;Inflammation;Interferon alpha;Interferons;Label;Lead;Ligation;Maps;Mass Spectrum Analysis;Mediating;Mediator;Modeling;Molecular;mouse model;multidisciplinary;Mus;mutant;Mutate;Mutation;new therapeutic target;novel;novel therapeutics;overexpression;Pathway interactions;Patients;Peptides;Peripheral Blood Mononuclear Cell;Pharmaceutical Preparations;Phenotype;Post-Translational Protein Processing;Predisposition;prevent;Process;programmed cell death ligand 1;programmed cell death protein 1;protective effect;Proteins;response;Role;Signal Transduction;Stress;Susceptibility Gene;T-Lymphocyte;T-Lymphocyte Epitopes;Techniques;Testing;Thyroglobulin;Thyroid Gland;Thyroiditis;Time;Toxic effect;Translating;Up-Regulation;Variant;Viral;Virus Diseases

PROJECT_TITLE: Analyzing genetic and environmental molecular mechanisms causing autoimmune thyroid diseases

STUDY_SECTION: CSME

STUDY_SECTION_NAME: Cell Signaling and Molecular Endocrinology Study Section[CSME]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: HOUSTON

ORG_NAME: TEXAS HEART INSTITUTE

ORG_STATE: TX

PHR: PROJECT NARRATIVE Heart failure is a significant public healthcare burden in the USA, with approximately 400,000 heart failure- related deaths occurring yearly. As a promising treatment for end-stage heart failure, the left ventricular assist device (LVAD) is used to help a failing heart pump blood; however, with complications, such as bleeding, stroke, thrombosis, and driveline infection. To mitigate these problems, we propose to develop a novel magnetic levitated LVAD by adopting expandable stented inlet and slippery hydrophilic (SLIC) coatings to improve hemocompatibility.

PI_NAMEs: DASI, LAKSHMI PRASAD;FRAZIER, O. H. (contact);KOTA, ARUN KUMAR

PROGRAM_OFFICER_NAME: LIU, SONGTAO

PROJECT_TERMS: 3-Dimensional;Adopted;Adsorption;Affinity;Animal Model;Architecture;Blood;blood damage;Blood Proteins;blood pump;Cannulas;Cessation of life;Chemicals;Complication;design;Destinations;Development;Device Designs;Devices;Electrocardiogram;Evaluation;experimental study;Feasibility Studies;healthcare burden;Heart;Heart failure;Heart Rate;Heart Transplantation;Heart Valves;hemocompatibility;hemodynamics;Hemolysis;Hemorrhage;Hydration status;hydrophilicity;Image;Implant;implantation;improved;In Vitro;in vivo;Infection;infection risk;innovation;Interdisciplinary Study;Investigation;Left;left ventricular assist device;Longevity;Machine Learning;Magnetism;Mobility decline;Molecular;novel;Outcome;particle;Patients;Performance;Persons;Positioning Attribute;Property;Proteins;prototype;Public Health;Pump;Quality of life;Reaction;Research Project Grants;Resolution;response;Risk;sensor;Series;Signal Transduction;Speed;Stents;Stroke;success;Surface;surface coating;System;Technology;Testing;Therapeutic;Thrombosis;thrombotic;transmission process;Validation;Velocimetries;Ventricular

PROJECT_TITLE: Maglev LVAD with expandable stented inlet and anti-thrombotic coating to improve hemocompatibility

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative In this proposal we aim to understand the mechanisms by which neural populations represent stimuli in the environment and how these representations change with learning. These findings will pave the way for a better understanding of age-related cognitive decline and provide novel targets for therapeutics.

PI_NAMEs: KHEIRBEK, MAZEN A (contact)

PROGRAM_OFFICER_NAME: SABRI, MERAV

PROJECT_TERMS: Age-associated memory impairment;Aging;Amygdaloid structure;Animals;Area;Association Learning;Behavior;Behavioral;Brain;Calcium;cell type;Childhood;Classification;Code;Cognition Disorders;Complex;computerized tools;Computing Methodologies;Cues;Cytoplasmic Granules;Data Analyses;Data Set;dentate gyrus;Discrimination;Dopamine;Electrophysiology (science);Emotional;Emotions;entorhinal cortex;Environment;experience;flexibility;Goals;Health;Hippocampus;Human;Image;Imaging Device;imaging modality;Impaired cognition;in vivo;innovation;Lateral;Learning;Life;life span;Maps;Measures;Memory;Memory impairment;memory process;memory recall;Modernization;neural;neural circuit;Neurons;neuroregulation;Neurosciences;new therapeutic target;Odors;old mice;olfactory bulb;Olfactory Learning;olfactory stimulus;optogenetics;Pattern;piriform cortex;Population;Population Dynamics;Process;Resources;Rewards;Role;Sensory;Source;spatial memory;Stimulus;Synaptic Transmission;System;Techniques;Testing;therapeutic development;Viral;Work

PROJECT_TITLE: Circuit dynamics supporting associative learning in the dentate gyrus

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Dental, Oral, and Craniofacial Disease;Genetics;Human Genome;Infectious Diseases;Rare Diseases;Sexually Transmitted Infections

ORG_CITY: DALLAS

ORG_DEPT: DERMATOLOGY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: Circular ribonucleic acid (circRNA) molecules are enriched in head and neck squamous cell carcinomas (HNSCC) but their potential functions remain unclear. Through our study of human papillomavirus (HPV) circRNAs, we have developed novel approaches and tools to study circular RNA in HNSCC. This study will advance our understanding of HNSCC biology and may also identify new prognostic biomarkers and treatment approaches for HNSCC.

PI_NAMEs: WANG, RICHARD C (contact)

PROGRAM_OFFICER_NAME: READ-CONNOLE, ELIZABETH LEE

PROJECT_TERMS: Archives;Binding Proteins;biobank;Biochemical;Biological;Biological Process;Biology;circular RNA;Clinical Data;clinically relevant;Code;cohort;Data Set;Development;Digestion;Disease;Elements;Ensure;Epidemiology;Exonuclease;exosome;experimental study;Follow-Up Studies;Genetic;Goals;Head and Neck Cancer;Head and Neck Squamous Cell Carcinoma;HPV negative;HPV positive;HPV-negative head and neck cancer;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;Human papillomavirus 16;Inhibition of Cancer Cell Growth;inhibitor;innovation;insight;knock-down;Length;Malignant Neoplasms;Messenger RNA;Modification;Mucous Membrane;Mutagenesis;Nature;neoplastic;novel;novel strategies;Oncoproteins;oral HPV-positive head and neck cancers;overexpression;Pathogenesis;Pathology;Patients;Peptide antibodies;Physiological;Polyribosomes;Prognostic Marker;prognostic value;Property;protein function;Protein Splicing;Protein Truncation;Proteins;Protocols documentation;PTEN gene;Publishing;Regulation;Resistance;Resources;ribonuclease R;Ribosomal RNA;RNA;RNA metabolism;RNA Splicing;Role;Sampling;Series;skills;Testing;Tissues;tool;transcriptome sequencing;transcriptomic profiling;transcriptomics;Translating;Translations;tumor;Tumor Suppressor Proteins;tumorigenesis;tumorigenic;Validation;Viral Physiology;Virus Replication

PROJECT_TITLE: Regulation and Function of Viral and Endogenous Circular RNA in Cancer

STUDY_SECTION: CE

STUDY_SECTION_NAME: Cancer Etiology Study Section[CE]


NIH_SPENDING_CATS: Aging;Biotechnology;Eye Disease and Disorders of Vision;Genetics;Human Genome;Macular Degeneration;Neurodegenerative;Neurosciences;Prevention

PHR: NARRATIVE Age-related macular degeneration (AMD) is the most common cause of severe vision loss among older individuals. Variations in multiple genes strongly affect the risk of developing AMD but a substantial portion of the genetic architecture of risk, progression, response to treatment, and in different genetic ancestries remains unexplained. The International AMD Genomic Consortium (IAMDGC) addresses these gaps and seeks to develop a complete understanding of the genetic underpinnings of AMD as a pathway to better treatments and preventions.

PI_NAMEs: BLANTON, SUSAN HALLORAN;HAINES, JONATHAN L (contact);PERICAK-VANCE, MARGARET A.

PROGRAM_OFFICER_NAME: SHEN, GRACE L

PROJECT_TERMS: Address;Admixture;Affect;Age related macular degeneration;Agreement;American;Antibodies;bevacizumab;biobank;Biological;biological age;Biological Markers;Blindness;Caregivers;case control;central database;Clinical;clinical subtypes;cohort;Collaborations;Communication;Communities;computer infrastructure;cost;Data;data access;data curation;data harmonization;data repository;Data Set;database of Genotypes and Phenotypes;Development;Diagnostic;Diet;effective therapy;Ethics;Etiology;Europe;exome sequencing;Family;Family member;Foundations;Functional disorder;Funding;Fundus;Genes;Genetic;genetic architecture;genetic pedigree;Genetic Variation;genome wide association study;genomic data;Genomics;Genotype;Goals;Grant;Health Care Costs;Heritability;Heterogeneity;improved;Individual;Injections;Institution;International;large datasets;Logistics;Maps;Measures;meetings;member;Meta-Analysis;Metadata;Mining;multi-ethnic;Older Population;Participant;Pathway interactions;Pharmacologic Substance;Phenotype;phenotypic data;Policies;Population;Prevention;Preventive measure;Procedures;Process;programs;Quality of life;rare variant;repository;Research;Research Design;Resources;Risk;risk variant;Sampling;Site;Smoking;social;Speed;Teleconferences;Testing;Trans-Omics for Precision Medicine;Treatment Protocols;treatment response;Universities;Validation;Variant;Veterans;web site;working group

PROJECT_TITLE: International Advancing genomics through the AMD Genomics Consortium (IAMDGC)

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


NIH_SPENDING_CATS: Congenital Structural Anomalies;Genetics;Pediatric;Rare Diseases

ORG_DEPT: BIOCHEMISTRY

PHR: PROJECT NARRATIVE Primary cilia are small projections found on many human cells involved in receiving and interpreting signals from other cells. Misactivation of Hedgehog signaling, one type of ciliary signaling, causes cancers, including basal cell carcinoma and medulloblastoma. We are investigating the mechanisms by which Hedgehog ciliary signaling occurs in embryonic development and cancer.

PI_NAMEs: REITER, JEREMY F (contact)

PROGRAM_OFFICER_NAME: KOCH, PETER

PROJECT_TERMS: Alleles;appendage;Basal cell carcinoma;Binding;Biochemical;Biological;Cancer Etiology;Cells;Chemicals;Cilia;ciliopathy;cilium biogenesis;Cleavage Under Targets and Release Using Nuclease;Communication;Congenital Abnormality;Defect;Development;Disease;Drosophila genus;Embryonic Development;Environment;Erinaceidae;experimental study;Genetic;Genetic Transcription;genome editing;GLI gene;GLI2 gene;hedgehog signal transduction;Holoprosencephaly;Human;Image;insight;Integral Membrane Protein;intercellular communication;Knock-in;Ligands;Lipids;Malignant Neoplasms;Mammalian Genetics;Mammals;Medulloblastoma;Membrane;Microscopy;Modeling;Molecular;Morphology;mouse model;Movement;North America;novel;novel therapeutic intervention;Pathway interactions;Pattern;Phosphatidylinositols;Phosphotransferases;Polydactyly;programs;receptor;Research;Shapes;SHH gene;Signal Transduction;Signal Transduction Pathway;smoothened signaling pathway;Specificity;Sterols;Testing;Tissues;tool;transcription factor;transmission process;tumorigenesis;Tyrosine Phosphorylation;Vertebrates;Work

PROJECT_TITLE: Hedgehog signaling at the cell's antenna: Smoothened and the primary cilium

STUDY_SECTION: ICI

STUDY_SECTION_NAME: Intercellular Interactions Study Section[ICI]