ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: OVERALL: PROJECT NARRATIVE  HOPE & CAIRHE 2gether (HC2) brings together the expertise, infrastructure, partnerships, and resources of the Center for Health Outcomes and Population Equity (HOPE), Huntsman Cancer Institute, and University of Utah, with the Center for American Indian and Rural Health Equity (CAIRHE) and Montana State University. The overall, long-term goal of HC2 is to increase the reach of evidence-based cancer prevention and control interventions in areas of persistent poverty. The two research projects will work in persistent poverty census tracts and in partnership with Community Health Centers in Utah, and with Cooperative Extension Systems and American Indian communities in Montana, Oregon, South Dakota, and Wisconsin, to mitigate adverse impacts of the social determinants of health, increase tobacco cessation, and prevent obesity.

PI_NAMEs: ADAMS, ALEXANDRA K.;WETTER, DAVID W (contact)

PROGRAM_OFFICER_NAME: HARDESTY, REBECCA ANNE

PROJECT_TERMS: Address;Adoption;Advanced Malignant Neoplasm;American Indian community;American Indians;Area;Belief;Cancer Burden;Cancer Center;Cancer Control;Cancer Control Research;cancer prevention;Cancer Prevention Intervention;Carcinogens;career;Censuses;Collaborations;Communities;community advisory board;community engagement;community organizations;community partners;community partnership;diabetes prevention program;Dissemination and Implementation;Eligibility Determination;Equity;evidence base;experience;Fostering;frontier;Funding;Goals;Health;health equity;health goals;health inequalities;Healthcare Systems;implementation research;implementation strategy;improved;Individual;Infrastructure;innovation;Institution;Intervention;Latino;Leadership;life span;low socioeconomic status;Malignant Neoplasms;Mentors;Methods;Montana;National Cancer Institute;Neighborhood Health Center;obesity prevention;Oregon;Outcome;patient oriented;Pilot Projects;Policies;Population;Poverty;Poverty Areas;Prevention program;Prevention Research;Primary Care;programs;Public Health;quitline;Recording of previous events;Research;Research Infrastructure;Research Personnel;Research Project Grants;Resources;Rural;Rural health equity;Scientist;Services;social health determinants;South Dakota;Structure;synergism;System;tobacco cessation intervention;Tobacco use;Tobacco Use Cessation;Training Activity;Training Programs;translational research program;tribal community;Universities;Utah;Wisconsin;Work

PROJECT_TITLE: Multi-sector, multi-level interventions for improving cancer prevention and control addressing persistent poverty


ADMINISTERING_IC: AG

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_CITY: GAINESVILLE

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PI_NAMEs: LEEUWENBURGH, CHRISTIAAN  (contact)

PROJECT_TERMS: age-related disease;Aging;aging biomarker;aging mechanism;American;analytical tool;Ancillary Study;Autophagocytosis;biobank;Biochemical;Biological;Biological Markers;Biology;biomarker selection;Blood;Blood capillaries;Brain;Cell Aging;Cell Physiology;Cell Separation;Cells;Circadian Dysregulation;circadian pacemaker;Clinical Research;Clinical Sciences;Coenzymes;cognitive function;Collaborations;Complementary DNA;Complex;Consultations;Country;Data;deregulated nutrient-sensing;design;detection platform;Deterioration;Disease;DNA;DNA copy number;DNA Markers;education research;Electron Transport;enzyme activity;Enzyme-Linked Immunosorbent Assay;Epigenetic Process;Fatty acid glycerol esters;Florida;Freezing;Future;Gene Expression Profiling;Genomic Instability;Genomics;Geroscience;Goals;healthy aging;high standard;high throughput analysis;Homeostasis;Human;Human Resources;Immunoassay;Inflammation;Infrastructure;innovation;interest;Intervention;Knowledge;Laboratories;late life;Leukocytes;life span;Measures;Metabolic Pathway;Metabolism;metabolomics;Methodology;Mitochondria;Mitochondrial DNA;mitochondrial dysfunction;Mobility decline;Molecular;Monitor;Muscle;Mutation;NADH;NADP;nanoimmunoassay;Nicotinamide adenine dinucleotide;novel;Nuclear;Organelles;Pathway interactions;Pattern;Physical Function;Physiological Processes;Pilot Projects;Plasma;pre-clinical;Principal Investigator;Protein Analysis;Proteins;Proteomics;proteostasis loss;Qualifying;rate of aging;Reaction;Reader;Recording of previous events;Research;Research Personnel;research study;Research Support;Resolution;Resources;Respiration;Respiratory physiology;RNA;Sampling;Scientist;senescence;Sensory;Serum;Services;specific biomarkers;Spirometry;stem cell exhaustion;Techniques;Technology;Telomere Shortening;Time;Tissue Sample;Tissues;Touch sensation;transcriptomics;Translational Research;Universities;Vertebral column;Western Blotting;Whole Blood

PROJECT_TITLE: Metabolism and Translational Science Core


NIH_SPENDING_CATS: Aging;Clinical Research

PI_NAMEs: QIU, PEIHUA  (contact)

PROJECT_TERMS: Adherence;Aging;American;Attention;BCL1 Oncogene;Biological Aging;biomarker discovery;Biometry;Biostatistical Methods;Biostatistics Core;Cancer Center;Capsicum;Clinical Data;Clinical Research;Clinical Trials Design;Collaborations;Computer software;computerized data processing;Computers;Data;Data Analyses;Data Collection;data collection site;data management;Data Management Resources;data repository;Data Science;Data Security;Databases;design;Development;Discipline;Disease;Early Diagnosis;education research;Ensure;experience;Extramural Activities;Faculty;Florida;Funding;Future;Genetic;genomic data;Geroscience;Goals;Health;Human Resources;image processing;interdisciplinary approach;interest;intervention effect;late life;Leadership;Manuscripts;Measurement;Measures;Metabolism;Methodology;Methods;Mission;Monitor;older adult;Outcome;Pattern;Periodicals;Phase;Physical Performance;power analysis;preclinical study;Preparation;Procedures;programs;Protocols documentation;Publications;Qualifying;Quality Control;Randomized;recruit;Research;research and development;research data dissemination;Research Design;Research Personnel;Resources;Sample Size;Scheme;Scientist;screening;Services;Site;Source;Statistical Computing;Statistical Data Interpretation;Statistical Methods;Technology;Testing;Time;tool;Training;Translational Research;Universities;web app;Writing

PROJECT_TITLE: Biostatistics Core


ADMINISTERING_IC: AI

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Genetics;Immunotherapy;Organ Transplantation;Transplantation;Women's Health Research

ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PI_NAMEs: CHONG, ANITA S (contact)

PROJECT_TERMS: Address;Allograft Tolerance;Allografting;anergy;Antigen-Presenting Cells;Antigens;Biological Markers;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;Cells;chromatin remodeling;Clinical;CTLA4 gene;exhaust;exhaustion;Exhibits;expectation;experience;Fetus;Frequencies;Heart;heart allograft;Heart Transplantation;Hematopoietic Stem Cell Transplantation;Immunosuppression;Infection;insight;Knowledge;Link;Mediating;Memory;memory CD4 T lymphocyte;Modeling;novel therapeutics;offspring;Pathway interactions;pharmacologic;Phenotype;Physiological;post pregnancy;Postpartum Period;Predisposition;Pregnancy;prevent;Process;programmed cell death protein 1;programs;Regulatory T-Lymphocyte;Reporting;Resistance;Resistance development;sex;Skin graft;synergism;T memory cell;T-Lymphocyte;Testing;Therapeutic;TNFSF5 gene;transcriptome;Transplant Recipients;Transplantation;Transplantation Tolerance;Treg therapy;Weaning

PROJECT_TITLE: Confronting the Barrier to Stable Transplantation Tolerance Posed by Memory T Cells


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Fetal Alcohol Spectrum Disorders (FASD);Intellectual and Developmental Disabilities (IDD);Networking and Information Technology R&D (NITRD);Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Substance Misuse

ORG_CITY: OXFORD

ORG_COUNTRY: UNITED KINGDOM

ORG_FIPS: UK

ORG_NAME: UNIVERSITY OF OXFORD

ORG_ZIPCODE: OX1 2JD

PHR: Automated tools will be developed to better identify those with suspected prenatal alcohol exposure using a combination of 3D facial imaging and neurocognitive testing using low-cost imaging devices. We will utilize outputs from online cognitive assessment (FASD-Tree and Brain-Online) tools to improve sensitivity/specificity for the identification of FASD. Machine learning approaches will be applied to achieve automated objective analysis of facial images and deployed on a cloud server for worldwide, multi-device accessibility. To ensure our tools are optimized, we will investigate the impact on facial dysmorphism of age, ethnicity, sexual dimorphism, and co-exposures. These tools will facilitate and support the recognition of individuals with FASD, who may need further support, and will include infants through to adults using a fully automated and objective approach, using low-cost solutions and providing an accessible toolkit for clinicians.

PI_NAMEs: SUTTIE, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: DUNTY, JR, WILLIAM

PROJECT_TERMS: 3-Dimensional;Address;Adolescent;Adult;Age;Agreement;alcohol consumption during pregnancy;alcohol exposure;Alcohols;Assessment tool;Automation;Brain;brain morphology;brain shape;Categories;Cellular Phone;Cephalic;Child;Clinic;Clinical;clinical application;Clinical assessments;clinical diagnosis;cloud platform;Cognitive;cognitive testing;Collaborations;Communities;comparative;Computer software;Corpus Callosum;cost;Data;Data Management Resources;Data Set;deep learning;Devices;Diagnosis;Discrimination;Elements;Ensure;Ethnic Origin;Evaluation;experience;Face;Feedback;Fetal alcohol effects;Fetal Alcohol Exposure;Fetal Alcohol Spectrum Disorder;Fetal Alcohol Syndrome;Goals;Image;Image Analysis;imaging detection;Imaging Device;Impaired cognition;improved;Individual;Infant;Intervention;Intervention Studies;Length;Life;life span;Lip structure;Literature;Machine Learning;Mandible;Measurement;Methodology;Methods;Micrognathism;midfacial hypoplasia;Morphology;MRI Scans;Neonatal;neural;Neurocognitive;neurocognitive test;Ocular orbit;offspring;Online Systems;Orbital separation excessive;Outcome;Output;Parents;polysubstance use;Population;R24;recruit;Request for Applications;Research;Resources;screening;Screening procedure;Secondary to;Sensitivity and Specificity;sex;Sex Differences;sexual dimorphism;Shapes;skills;Smoking;Surface;System;Tablets;Techniques;Technology;Testing;Thinness;Three-Dimensional Image;Three-Dimensional Imaging;Time;tool;Training;trait;Translating;translational approach;translational goal;Trees;Ultrasonography;ultrasound;Validation;Variant;Work

PROJECT_TITLE: Defining Translational Approaches for the Image-based Detection of Prenatal Alcohol Exposure


NIH_SPENDING_CATS: Aging;Bioengineering;Clinical Research;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Telehealth

PI_NAMEs: MANINI, TODD  (contact)

PROJECT_TERMS: Address;Age;Aging;aging population;American;Applications Grants;Artificial Intelligence;Big Data;Biomedical Engineering;Biostatistics Core;Cell Aging;Cellular Phone;Clinical assessments;Clinical Data;Clinical Research;Clinical Trials;cohort;Collaborations;Common Data Element;Communication;complex data;Computer Models;computer science;Computer software;Computer Systems;Computers;connected health;COVID-19;Data;Data Analyses;Data Collection;data ecosystem;data integration;data mining;data repository;Data Science;Data Sources;data streams;deep learning;demographics;design;Development;Device Designs;Ecological momentary assessment;Ecosystem;education research;Elasticity;Elderly;Electronic Health Record;Emerging Technologies;Engineering;Environment;Epidemiology;Etiology;Event;Expert Systems;Explosion;flexibility;Florida;forgetting;Future;Geriatrics;Gerontology;Geroscience;Goals;handheld mobile device;Harvest;Health;Health Technology;improved;innovation;insight;interdisciplinary approach;Intervention;Learning;Link;Location;Machine Learning;machine learning method;Medical;meetings;Mentors;Metabolism;Methodology;mHealth;mhealth interventions;mobile computing;Monitor;multimodal data;multimodal modeling;new technology;older adult;open source;Output;Participant;Patients;Pattern;Perception;Phenotype;phrases;Physicians;Physiological;Population;predictive modeling;Process;programs;remote technology;Research;research and development;Research Personnel;Resolution;Resources;Role;Science;sensor;Series;Services;Signal Transduction;smart device;smart watch;software development;Software Framework;Statistical Data Interpretation;Symptoms;Techniques;Technology;Testing;Time;tool;Training;Translational Research;Universities;unstructured data;usability;wearable sensor technology

PROJECT_TITLE: Data Science and Applied Technology Core


NIH_SPENDING_CATS: Aging;Chronic Pain;Clinical Research;Pain Research;Prevention

PI_NAMEs: CRUZ-ALMEIDA, YENISEL  (contact)

PROJECT_TERMS: addiction;Address;Adoption;Aging;Alzheimer's Disease;American;animal safety;ARNTL gene;Award;Basic Science;Behavioral Sciences;Berry;Biochemical;Biostatistics Core;career;Career Mobility;Clinical;clinical practice;Clinical Research;Clinical Sciences;Collaborations;Community Dentistry;Consult;Data;Data Analyses;Data Set;data warehouse;Databases;design;Development;disability;Discipline;Doctor of Philosophy;dosage;Education;Ensure;Environment;Exercise;experience;Extramural Activities;Florida;Fostering;functional genomics;Funding;Future;Goals;Grant;Health behavior;Health education;healthspan;Human;human subject;Immunology;inflammatory marker;Infrastructure;innovation;insight;instrumentation;interdisciplinary approach;Intervention;Laboratories;Malignant neoplasm of pancreas;Malignant Neoplasms;Medicine;metabolomics;Minority;minority investigator;Mobility decline;model design;Monitor;novel;older adult;older patient;Older Population;opioid use disorder;Pain;Pain Research;Pathology;Physical Function;Physiology;Pilot Projects;preclinical study;Prevention;Process;recruit;Research;Research Design;Research Personnel;research study;resilience biomarker;Resources;Role;Secure;Skeletal Muscle;Sleep;Statistical Data Interpretation;success;Talents;Technology;Testing;Time;Translating;Translational Research;Translations;Underrepresented Minority;United States National Institutes of Health;Universities

PROJECT_TITLE: Pilot and Exploratory Studies Core


ADMINISTERING_IC: EY

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Bioengineering;Biotechnology;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences

ORG_CITY: BIRMINGHAM

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Project Narrative Glaucoma is a leading cause of blindness worldwide. Until now, mechanistic-based studies focused on optic nerve head (ONH) and sclera biomechanics and their intraocular pressure (IOP) –related behavior. This project posits a new hypothesis proposing an intrinsic mechanical interaction between sclera and vitreous humor as modulator of the ONH-sclera biomechanics during dynamic IOP variations occurring in physiological conditions. This project will define the impact of the age-related vitreous degeneration and vitreous replacement on sclera biomechanics. Additionally, we will determine how sclera response to IOP dynamics can be restored/improved by using hydrogel vitreous substitutes.

PI_NAMEs: BIANCO, GIANFRANCO  (contact)

PROGRAM_OFFICER_NAME: SONG, HONGMAN

PROJECT_TERMS: absorption;Age;age effect;age related;age related changes;Aging;Animal Model;anterior chamber;Attenuated;Behavior;Biomechanics;Biomimetics;Blindness;Blood Pressure;Center Core Grants;Cerebrospinal Fluid Pressure;Characteristics;Clinical;Complex;Core Grant;Craniocerebral Trauma;Data;design;Device Designs;Environment;Eye;Frequencies;Gel;Glaucoma;Human;human data;Hydrogels;Impairment;improved;Incidence;Infusion procedures;Injury;insight;lens;Life;Liquid substance;Longitudinal Studies;Measurement;Measures;Mechanical Stress;Mechanics;Mediator;Methods;Modeling;novel;novel strategies;Optic Disk;Papillary;Periodicity;Phase;Physiologic Intraocular Pressure;Physiological;Pilot Projects;Predisposition;Property;Publishing;response;Retina;Role;Saline;Sampling;Sclera;sensor;Stress;Study models;System;Testing;translational potential;transmission process;Variant;viscoelasticity;Vitreous Chamber;Vitreous humor

PROJECT_TITLE: The impact of age-related vitreous degeneration and vitreous replacement on scleral biomechanics: a novel mechanism and treatment target for glaucoma

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-NV-P(81)S]


PROJECT_TERMS: Achievement;Address;Adult;Age;age group;aged;Aging;aging related;Alzheimer's Disease;American;Aptitude;Area;Attention;Award;Basic Science;Behavioral;Behavioral Sciences;Bioinformatics;Biological Markers;Biometry;Biostatistics Core;career;Career Choice;career development;Clinical;clinical center;Clinical Research;Clinical Sciences;college;Common Core;Competence;Competency-Based Education;Core Facility;Data Science;Developed Countries;Development;Development Plans;disability;Disease;doctoral student;education planning;education research;effective intervention;Elderly;Ensure;Environment;Epidemiology;Evaluation;experience;Extramural Activities;Face;Fellowship;Florida;Fostering;Funding;Future;Geriatrics;Goals;Health;health disparity;Home;Individual;insight;Institute of Medicine (U.S.);interdisciplinary approach;Interdisciplinary Study;Intervention;Investigation;K-Series Research Career Programs;Knowledge;Leadership;Mentors;Mentorship;Minority;Mission;Monitor;Neurology;next generation;older adult;Older Population;Operative Surgical Procedures;Pain;Persons;Physical therapy;Population;Population Research;Population Sciences;Postdoctoral Fellow;pre-clinical research;preservation;prevent;Process;professor;programs;Public Health;Qualifying;recruit;Research;research and development;Research Personnel;Research Project Grants;Research Support;Research Training;Resources;responsible research conduct;Role;Scholars Program;Science;Scientist;skill acquisition;skills;social;Stress;Structure;Talents;Technology;Testing;Time;Training;Training Activity;translational pipeline;Translational Research;Translations;Travel;Tsunami;United States;United States Department of Veterans Affairs;United States National Institutes of Health;Universities;Wages;Woman

PROJECT_TITLE: Research Education Core


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Infectious Diseases;Maternal Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Women's Health Research

ORG_CITY: Chicago

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: PROJECT NARRATIVE Listeria monocytogenes continues to be an increasingly significant health threat as it has been associated with numerous multi-state food-borne outbreaks that have resulted in thousands of illnesses and several hundred deaths within the past few years. The largest and most expensive recalls of food products in history have occurred as a result of L. monocytogenes contamination, and the bacterium poses a significant threat to pregnant women who may not even realize they have been infected. This proposal is focused on identifying and deciphering how select subpopulations of L. monocytogenes are enhanced for transmission from mother to developing fetus during pregnancy.

PI_NAMEs: FREITAG, NANCY ELIZABETH (contact)

PROGRAM_OFFICER_NAME: BAQAR, SHAHIDA

PROJECT_TERMS: Amino Acids;Antibiotic Therapy;Bacteria;Bacterial Infections;Binding;Birth;Brain Abscess;Cardiac;Cardiac Myocytes;Cell surface;cell type;Cells;Cellular Metabolic Process;Cessation of life;Data;Death Rate;Disease;Embryonic Development;Exhibits;fetal;Fetal Death;Fetal Development;fetal immunity;fetal infection;Fetal Tissues;Fetus;Food;Food Processing;foodborne;foodborne outbreak;Frequencies;Functional disorder;gene product;Genetic Crosses;Genetic Variation;Gentamicins;Goals;Growth Factor Receptors;Health;Heart;high risk population;Human;Immune response;Immune signaling;Immunocompromised Host;In Vitro;in vivo;individual patient;infant infection;Infection;Injury;InlB protein;insight;Invaded;Listeria;Listeria monocytogenes;Maternal-Fetal Transmission;Membrane Proteins;Meningitis;Meningoencephalitis;microorganism;Modification;Molecular;Mothers;Mus;Neonatal;novel therapeutic intervention;older patient;Organism;pathogen;pathogenic bacteria;Pathogenicity;Pathology;Pharmaceutical Preparations;Placenta;Placentation;Play;Pregnancy;Pregnancy Outcome;pregnant;Pregnant Women;Proteins;receptor;receptor binding;Recording of previous events;Resistance;Role;Signal Pathway;stillbirth;Surface;Teratogenic effects;Tertiary Protein Structure;tissue tropism;Tissues;transmission process;uptake;Variant;Vertical Transmission;viral resistance;Virulence;wasting;Woman;Work;Zika Virus

PROJECT_TITLE: Deciphering mechanisms of Listeria placental-fetal invasion

STUDY_SECTION: HIBP

STUDY_SECTION_NAME: Host Interactions with Bacterial Pathogens Study Section[HIBP]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

PI_NAMEs: WETTER, DAVID W (contact)

PROJECT_TERMS: Achievement;Address;Advanced Malignant Neoplasm;American Indians;Area;Cancer Control;Cancer health equity;cancer prevention;career;Censuses;Collaborations;Collection;Communication;Communities;community engaged research;community engagement;Community Networks;Community Outreach;community partners;data sharing;Development;Development Plans;Doctor of Philosophy;Educational workshop;effectiveness evaluation;empowerment;Ensure;Equity;Evaluation;Fostering;Foundations;frontier;Goals;Guidelines;Health;health equity;Health equity research;Healthcare;Human Subject Research;Huntsman Cancer Institute at the University of Utah;Impact evaluation;improved;Individual;Infrastructure;Institution;Intervention;Latino;Leadership;Malignant Neoplasms;Measures;meetings;Mentors;Mission;Montana;multidisciplinary;next generation;Outcome;outreach;Pilot Projects;Policies;poor communities;Population;Poverty;Poverty Areas;Prevention Research;prevention service;Principal Investigator;Process;Program Development;Public Health;Research;Research Methodology;Research Personnel;Research Project Grants;Resource Sharing;Resources;Rural;Rural health equity;Scientist;success;Surveys;synergism;tool;Training;tribal organization;Tribes;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Social Determinants of Health

PI_NAMEs: SMITH, JUSTIN D (contact)

PROJECT_TERMS: Address;Adoption;Advanced Malignant Neoplasm;Area;Behavior;Biometry;Cancer Control;cancer prevention;Cancer Prevention Intervention;career;Child;Collaborations;Common Data Element;community engagement;Community Services;data sharing;economic evaluation;Ensure;Environmental Exposure;Equity;evaluation/testing;evidence base;Evidence based intervention;experience;Family;Fostering;Goals;Health;health care service;health economics;health equity;Health equity research;implementation evaluation;implementation facilitation;implementation outcomes;implementation process;implementation research;implementation science;implementation strategy;improved;Individual;individualized prevention;Inequity;Infrastructure;innovation;Intervention;Knowledge;Leadership;Logic;Malignant Neoplasms;Measurement;Measures;Methodology;Methods;Modeling;Modification;mortality disparity;novel;Outcome;Persons;Pilot Projects;Policies;Population;Poverty;Poverty Areas;prevent;Prevention;Prevention program;Productivity;Reproducibility;Research;Research Activity;Research Design;Research Methodology;Research Project Grants;Research Project Summaries;Research Support;Resources;scale up;Science;Specific qualifier value;Structure;synergism;System;Techniques;Time;tool;Training;Translational Research;Underserved Population;United States National Institutes of Health;Work;Youth

PROJECT_TITLE: Research and Methods Core


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Machine Learning and Artificial Intelligence;Patient Safety;Prevention;Primary Health Care;Social Determinants of Health;Substance Misuse;Telehealth;Tobacco;Tobacco Smoke and Health

PI_NAMEs: SCHLECHTER, CHELSEY  (contact)

PROJECT_TERMS: Accounting;Address;Adopted;Adoption;Adverse event;Cancer Control;cancer prevention;cancer type;Caring;Cause of Death;Cellular Phone;Censuses;chatbot;Clinic;Clinic Visits;Clinical;clinical encounter;Community Participation;contextual factors;cost effectiveness;Data;design;disability;Dissemination and Implementation;dissemination strategy;Effectiveness;effectiveness/implementation trial;Electronic Health Record;Enrollment;Equity;Esophagus;evidence base;Evidence based intervention;Experimental Designs;federal poverty level;Health;health care settings;Health Care Visit;health equity;health inequalities;health information technology;Healthcare Systems;implementation science;implementation strategy;implementation/effectiveness;improved;Individual;Inequity;innovation;Intervention;intervention delivery;Language;Larynx;Latino;Lip Cancer;Lung;Maintenance;malignant mouth neoplasm;marginalization;Modality;mortality;Neighborhood Health Center;novel;Outcome;patient navigation;patient navigator;patient oriented;Patients;Pharyngeal structure;Play;point of care;Population;Poverty;Poverty Areas;Prevalence;Prevention program;primary care clinic;primary outcome;programs;quitline;Randomized;Research;Resources;Role;safety net;screening;secondary analysis;Services;smoking-related disease;social health determinants;socioeconomics;System;Technology;technology intervention;telehealth;Telephone;telephone based;Testing;Tobacco;tobacco cessation intervention;Tobacco use;Tobacco Use Cessation;Trachea;Underserved Population;Uninsured;United States;Use Effectiveness;Utah;Work

PROJECT_TITLE: Multi-level interventions for addressing tobacco cessation and SDOH in Community Health Centers (CHCs)


NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Cancer;Childhood Obesity;Clinical Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

PI_NAMEs: ESTABROOKS, PAUL  (contact)

PROJECT_TERMS: Address;Adopted;Adoption;Adult;American Indian community;American Indian Population;American Indians;Area;Behavioral;budget impact;Cancer Control;cancer prevention;Cancer Prevention Intervention;cancer risk;Child;Child Health;Childhood;Chronic Disease;collaborative approach;Communities;community advisory board;community based participatory research;community engagement;community partners;community-level factor;Complex;cost effectiveness;County;Data;Data Collection;design;Development;Diet;disorder prevention;disorder risk;Disparity;Dissemination and Implementation;dissemination science;early childhood;Economics;Education;Educational Personnel;effectiveness evaluation;Equity;Evaluation;evidence base;Evidence based intervention;experience;Family;Focus Groups;food insecurity;food resource;Food Safety;frontier;fruits and vegetables;Goals;Grant;Health;Health behavior;Health behavior change;health equity;Health Food;health inequalities;Healthy Eating;Home;implementation science;implementation strategy;improved;Individual;Inequity;innovation;Intake;Intervention;intervention delivery;Interview;Island;life span;Maintenance;Malignant Neoplasms;Methods;Modeling;Montana;Names;North America;novel;nutrition;Obesity;Obesity associated cancer;obesity in children;obesity prevention;obesity risk;Oregon;Outcome;Parents;Physical activity;Population;Poverty;Poverty Areas;Prevention strategy;preventive intervention;Production;programs;randomized, clinical trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;repository;Research;Research Project Grants;Resources;Risk;Rural;satisfaction;Services;social;South Dakota;Special Supplemental Nutrition Program for Women, Infants, and Children;Specific qualifier value;Surveys;System;Trauma;Turtles;Universities;Wisconsin

PROJECT_TITLE: Delivery of Turtle Island Tales to Promote Family Wellness


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Autism;Brain Disorders;Genetics;Infectious Diseases;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention;Women's Health Research

ORG_CITY: STATEN ISLAND

ORG_NAME: INSTITUTE FOR BASIC RES IN DEV DISABIL

ORG_STATE: NY

PHR: Project Narrative Autism spectrum disorder (ASD) is a complex set of related neurodevelopmental disorders expressed within the first two to three years of life and carries a high economic cost to the affected families as well as to their communities. In contrast with the neonatal brain, the placenta represents a universally accessible organ suitable for population screening that may provide markers for ASD risk. The proposed project is a retrospective review of electronic medical records and biospecimens (placental formalin-fixed, paraffin- embedded tissue blocks) and newborn dried blood spots, which will be analyzed for ASD genetic risk, a broad range of markers of placental and newborn inflammation, and epigenetic modifications to ASD diagnoses after adjustment for maternal and neonatal covariates

PI_NAMEs: SALAFIA, CAROLYN M (contact)

PROGRAM_OFFICER_NAME: OREILLY, JULIA JIAQI

PROJECT_TERMS: Acute;Affect;Amniotic Fluid;Apoptosis;Archives;autism biomarker;autism spectrum disorder;Basal Plate;Biological Assay;Birth;Blood;Blood Vessels;Brain;case control;Case/Control Studies;Cell Physiology;cell type;chemokine;Child;Childhood;Chronic;Clinic;Clinical;cohort;Communities;Community Healthcare;Complex;Computer Assisted;Computerized Medical Record;cytokine;Data;Decidua Basalis;deep learning;Development;Diagnosis;disorder risk;DNA Methylation;Dryness;Early Intervention;economic cost;Emotional;Environment;Epigenetic Process;Exposure to;Family;Female;fetal;Formalin;Functional disorder;gene network;Genes;Genetic;Genetic Risk;Genome;Goals;Growth;Growth Factor;Heredity;Histologic;Histopathology;Hospitals;immune activation;Immune signaling;Immunophenotyping;Impairment;improved;in utero;Infant;Infection;Inflammation;Inflammatory;inflammatory marker;Label;Language;Life;Link;male;Measures;Methodist Church;Methods;Methylation;methylation pattern;Modeling;Modification;Neonatal;neonatal brain;Neonatal Screening;neonate;neurodevelopment;Neurodevelopmental Disorder;Neuronal Dysfunction;neutrophil;New York;Newborn Infant;Organ;Paraffin Embedding;Pathogenesis;Pathology;Pathway interactions;Perinatal;Perinatal Infection;Placenta;Population;population based;Pregnancy;prenatal;prenatal exposure;prenatal risk factor;Preparation;Presbyterian Church;Process;Reproducibility;Research;Resources;Risk;Sampling;screening;sex;Siblings;Site;social;Spottings;Stereotyped Behavior;Surface;Symptoms;Testing;time use;tissue archive;Tissue Embedding;Tissues;Trees;United States;Villous;viral DNA;Virus Diseases;Work

PROJECT_TITLE: Contribution of maternal immune activation, viral infection and epigenetics to autism--a community-based case control study

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


PI_NAMEs: OKUYEMI, KOLAWOLE S (contact)

PROJECT_TERMS: Address;American Indians;Area;Biomedical Research;Cancer Burden;Cancer Control;Cancer health equity;cancer prevention;Cancer Prevention Intervention;career;career development;Collaborations;Communities;community collaboration;community engaged research;community engagement;community partners;cultural values;Development;Development Plans;Doctor of Philosophy;early-career faculty;Ensure;Equity;Ethnic Origin;experience;Faculty;Fostering;Funding;Geography;Goals;Grant;Health;health equity;implementation strategy;improved;Indigenous;Individual;Institution;Intervention;Knowledge;Leadership;Learning;Link;Malignant Neoplasms;member;mentoring community;Mentors;Methods;Modeling;Monitor;Montana;multidisciplinary;next generation;Outcome;Pathway interactions;Peer Review;Pilot Projects;poor communities;Population;Positioning Attribute;Postdoctoral Fellow;Poverty;Poverty Areas;pre-doctoral;Prevention Research;Process;programs;Publications;Race;recruit;Research;Research Design;Research Methodology;Research Personnel;Research Project Grants;Resource Development;Resources;Rural;Rural Health;Rural health equity;Science;Secure;Series;skills;social health determinants;Specialist;Structure;synergism;Training;Training Programs;Translating;Travel;Universities;Utah;Work;Writing

PROJECT_TITLE: Career Enhancement Core


NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Cancer;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Lung Cancer;Obesity;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

PI_NAMEs: DEL FIOL, GUILHERME  (contact)

PROJECT_TERMS: Address;Air;American Indians;Award;Belief;Cancer Control;cancer prevention;career;Censuses;Collaborations;Communities;community clinic;community engagement;community organizations;community partners;community partnership;Development;Dissemination and Implementation;early-career faculty;Ensure;Equity;evidence base;Foundations;Funding;Goals;Health;health inequalities;implementation research;implementation strategy;improved;Infrastructure;innovation;Institution;interest;Intervention;lung cancer prevention;Malignant Neoplasms;Mentors;Methods;Monitor;Montana;obesity prevention;Outcome;Pilot Projects;Population;Postdoctoral Fellow;Poverty;Poverty Areas;pre-doctoral;Procedures;Process;prospective;Radon;Research;Research Methodology;Research Personnel;Research Project Grants;Resources;Review Committee;Rural health equity;screening;Secure;senior faculty;social health determinants;Time;timeline;Tobacco;translational research program;tribal community;Universities;Utah;Work

PROJECT_TITLE: Developmental Core


ADMINISTERING_IC: LM

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Data Science;Kidney Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Precision Medicine;Prevention;Social Determinants of Health

ORG_CITY: INDIANAPOLIS

ORG_DEPT: PEDIATRICS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Narrative: We propose to develop the DisEase PrOgression Trajectory (DEPOT), an evidence-driven, graph- based clinical informatics approach to model chronic kidney disease (CKD) progression trajectories and individualize clinical decision support. The goal of this work is to use the IUSM EHR data collection to establish EHR-based CKD progression trajectories and to learn actionable knowledge to prevent drug-induced acute kidney injury (AKI) and CKD. The success of the proposed work will generate novel knowledge about the landscape of CKD health trajectories and nephrotoxic drug-drug interactions, bridging gaps between rich longitudinal EHR data and decision support for precision medicine in CKD.

PI_NAMEs: SU, JING  (contact);ZHANG, PENGYUE

PROGRAM_OFFICER_NAME: WANG, YANLI

PROJECT_TERMS: Acute Renal Failure with Renal Papillary Necrosis;Address;Adult;Affect;artificial intelligence model;Big Data;Characteristics;Chronic Disease;Chronic Kidney Failure;Clinic;Clinic Visits;Clinical;clinical care;clinical decision support;clinical encounter;Clinical Informatics;Clinical Sciences;Clonidine;cohort;Collection;comorbidity;Complex;complex data;Computerized Medical Record;Data;Data Collection;data harmonization;data modeling;Databases;Decision Making;Development;Diagnosis;Diet;Disease;Disease Management;Disease Progression;Disparate;Drug Combinations;Drug Interactions;Drug usage;Early identification;Economic Burden;economic determinant;Electronic Health Record;experience;Fluconazole;follow-up;General Population;Genetic;Glomerular Filtration Rate;Goals;Graph;Health;Health Insurance;Health system;heterogenous data;Incidence;indexing;Indiana;Individual;insurance claims;Knowledge;Knowledge acquisition;Learning;Life Expectancy;lifestyle factors;Mathematics;Medical;Medical Records;medical schools;medical specialties;Modeling;modifiable risk;Myopathy;nephrotoxicity;novel;novel strategies;novel therapeutics;Omeprazole;Pathogenicity;Patient Care;patient subsets;Patients;Pattern;personalized decision;Pharmaceutical Preparations;phenome;Population;precision medicine;Predisposition;prevent;Quality Control;Quality of life;reconstruction;Renal function;Research;Risk;Risk Factors;Signal Transduction;Societies;socioeconomics;Source;success;trait;Translational Research;Treatment outcome;underserved community;Universities;Work

PROJECT_TITLE: Revealing Health Trajectories of Chronic Kidney Disease for Precision Medicine

STUDY_SECTION: BLR

STUDY_SECTION_NAME: Biomedical Informatics, Library and Data Sciences Review Committee[BLR]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases;Rare Diseases;Vector-Borne Diseases

ORG_CITY: GALVESTON

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

ORG_STATE: TX

PHR: PROJECT NARRATIVE Mayaro and chikungunya are alphaviruses that cause Mayaro fever and chikungunya fever, respectively; they present with fever, headache, muscle pain, chills, and long-term debilitating joint pain. These viruses are transmitted by mosquitoes, and adaptation to urban mosquitoes allows them to cause large outbreaks. Understanding how these viruses adapt to urban mosquitoes is essential for improved surveillance of variants and studies of how these viruses interact with host factors will spur the development of countermeasures against Mayaro and chikungunya viruses.

PI_NAMEs: KROON CAMPOS, RAFAEL  (contact)

PROGRAM_OFFICER_NAME: DUPUY, LESLEY CONRAD

PROJECT_TERMS: Acute Disease;Aedes;Affect;Alpha Virus;Anti-viral Response;Arboviruses;Arthralgia;Binding Proteins;Biological Assay;Blood;Brazil;career;chikungunya;Chikungunya fever;Chikungunya virus;Chills;Chimera organism;Culicidae;design;Development;Disease;Disease Outbreaks;Dissection;Distant;Dose;Double-Stranded RNA;Drug Targeting;Elements;emerging virus;Environment;Epidemic;Evolution;experimental study;Fever;Financial Hardship;fitness;forest;Future;Genes;Genetic;Genome;genome-wide analysis;genomic RNA;Genomics;Genotype;Geography;global health;Goals;Headache;Healthcare Systems;Human;human pathogen;immune activation;Immune Evasion;Immune response;Immune system;Immunity;immunoregulation;improved;Infection;Injections;Integration Host Factors;Invertebrates;K-Series Research Career Programs;knock-down;Knowledge;Laboratories;Laboratory Study;Link;Mayaro virus;Methylation;Methyltransferase;Midgut;Minority;Modeling;Modification;Monitor;mortality;Mutagenesis;Mutation;Mutation Fixation;Myalgia;next generation sequencing;Nonstructural Protein;North America;novel;novel strategies;oral infection;Pathway interactions;peri-urban;Phosphorylation;Phosphorylation Site;Phylogenetic Analysis;Play;Principal Investigator;prospective;Proteins;Publishing;Reader;Regulation;Research Personnel;Risk;RNA;RNA chemical synthesis;RNA methylation;Role;Saliva;Salivary Glands;Series;Single Nucleotide Polymorphism;skills;surveillance strategy;Testing;Titrations;transmission process;Urbanization;Vaccines;Variant;vector;vector competence;Vertebral column;Viral;viral fitness;Viral Genome;viral RNA;viral transmission;Viremia;Virus;Virus Activation;Virus Diseases;virus host interaction;Virus Replication;Writing

PROJECT_TITLE: Assessing the roles of viral mutations and host factors in the transmission of Mayaro virus and other alphaviruses by urban mosquitoes

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases Advisory Committee[MID]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Services;Mental Health;Mental Illness;Prevention;Suicide;Suicide Prevention

ORG_CITY: Oakland

ORG_NAME: KAISER FOUNDATION RESEARCH INSTITUTE

ORG_STATE: CA

PHR: PROJECT NARRATIVE There is substantial clinical interest in suicide risk models as tools to more accurately identify patients at risk for suicide but little scientific evidence about the effectiveness of these models in real world settings compared to standard screening practices alone, and almost no guidance for their implementation in healthcare. This high-impact, innovative study has important clinical implications as health systems consider whether it makes sense to enhance their existing suicide prevention care models with a suicide risk model.

PI_NAMEs: YARBOROUGH, BOBBIJO H. (contact)

PROGRAM_OFFICER_NAME: RUDORFER, MATTHEW V

PROJECT_TERMS: Acceleration;Address;Adopted;Adult;advanced system;behavioral health;Bioinformatics;Caring;Clinic;Clinical;clinical application;Clinical Data;clinical implementation;Collaborations;Computer Models;cost;Data;data infrastructure;design;Effectiveness;effectiveness evaluation;effectiveness measure;effectiveness outcome;effectiveness/implementation trial;Electronic Health Record;Elements;Emergency Situation;Ensure;Failure;Feedback;Funding;Health;health care settings;Health Care Visit;Health Insurance;health record;Health Services;Health system;Healthcare;Hybrids;implementation design;implementation evaluation;implementation outcomes;implementation questions;improved;Individual;innovation;Inpatients;instrument;insurance claims;interest;Intervention;Leadership;Measures;medical specialties;Medicare/Medicaid;member;Mental Health;Michigan;Minnesota;Modeling;Monitor;Movement;National Institute of Mental Health;Oregon;Outcome;Outpatients;patient population;Patient Self-Report;Patients;Pilot Projects;Population Heterogeneity;pragmatic implementation;pragmatic trial;preference;prevent;Prevention approach;prevention service;Process;Process Assessment;Public Health;Questionnaires;Randomized;Reach, Effectiveness, Adoption, Implementation, and Maintenance;reducing suicide;Research;Resolution;response;Risk;risk prediction;screening;service engagement;Services;Severities;Site;statistics;suicidal risk;Suicide;Suicide attempt;suicide model;Suicide prevention;System;Testing;time use;tool;treatment as usual;trial design;United States;Washington

PROJECT_TITLE: Evaluating Effectiveness and Implementation of a Risk Model for Suicide Prevention Across Health Systems


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Contraception/Reproduction;Data Science;Heart Disease;Hypertension;Maternal Health;Maternal Morbidity and Mortality;Pregnancy;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Hypertensive disorders of pregnancy (HDP) are a major cause of maternal and infant morbidity and mortality, and emerging evidence suggests that environmental exposure during pregnancy may play an important role in the development of HDP and subsequent cardiovascular disease (CVD) after pregnancy. However, multiple challenges and knowledge gaps exist in previous studies such as the lack of studies considering different subtype, onset, and severity of HDP, the lack of considerations of the totality of environment (i.e. the exposome), and limited understandings on how environmental exposures during pregnancy may impact subsequent maternal CVD risk after delivery. Leveraging the unique statewide linked electronic health records-birth records data from OneFlorida, this study builds on our prior work in the external exposome, aiming to examine the associations between the external exposome and risk of HDP and early risk of maternal CVD after pregnancy as well as to develop predictive models of HDP and maternal CVD after pregnancy to guide precision preventions.

PI_NAMEs: HU, HUI  (contact)

PROGRAM_OFFICER_NAME: PRICE, CANDICE

PROJECT_TERMS: Accounting;Address;Area;Aspirin;Award;Big Data;Biological Markers;biomedical informatics;Birth Records;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;Cardiovascular system;career;career development;Cause of Death;Clinical;Clinical Research;Data;data resource;Data Science;Data Scientist;deep learning model;design;Development;digital repositories;Dose;Eclampsia;Electronic Health Record;Environment;Environmental Epidemiology;Environmental Exposure;Environmental Impact;Environmental Risk Factor;Epidemiologist;experience;fetal;Five-Year Plans;Florida;Funding;Goals;health data;High Risk Woman;Hypertension;Incidence;individualized prevention;infant morbidity/mortality;informal learning;insight;Knowledge;Leadership;Learning;Link;maternal morbidity;maternal risk;Measurement;Mediation;Mentorship;Modeling;modifiable risk;mortality;novel;Outcome;Pathogenicity;Perinatal;Perinatal Epidemiology;Play;post pregnancy;Postpartum Period;Postpartum Women;Pre-Eclampsia;predictive modeling;Pregnancy;Pregnancy Complications;pregnancy disorder;pregnancy hypertension;Pregnant Women;prevent;Prevention;Productivity;programs;Publications;Recording of previous events;Records;Research;Research Personnel;Research Project Grants;Residential Mobility;Risk;Risk Assessment;Risk Factors;Role;Severities;skills;sociodemographics;Source;Techniques;Testing;Training;Training Programs;Vital Statistics;Woman;Women's mortality;Work

PROJECT_TITLE: Hypertensive Disorders of Pregnancy and Early Risk of Maternal CVD: Influence of the External Exposome

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(JA)]


NIH_SPENDING_CATS: Asthma;Lung

ORG_CITY: PHILADELPHIA

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: THOMAS JEFFERSON UNIVERSITY

ORG_STATE: PA

PHR: NARRATIVE Asthma is a chronic disease of the lungs, which has been on the rise in recent decades. Our studies strongly suggest that E3 ligase pathway plays a central role in airway smooth muscle (ASM) dysfunction that is relevant to asthma and therefore, studies in this proposal aim to elucidate the role of novel E3 ligase, RNF145 in ASM functions. Establishing RNF145 as a target to ameliorate multiple components of lung pathology in asthma may lead to the development of novel, effective therapy for asthma in future.

PI_NAMEs: SHARMA, PAWAN  (contact)

PROGRAM_OFFICER_NAME: LU, JINING

PROJECT_TERMS: Adult;Affect;Aging;airway hyperresponsiveness;airway inflammation;airway remodeling;Alleles;Allergens;Allergic;Asthma;asthma model;asthmatic;asthmatic airway;Attenuated;Autophagocytosis;Biochemical;Biological Assay;Cell Cycle;cell growth;Cell model;Cell Physiology;Cell Proliferation;Cells;Chronic;Chronic Disease;Clinical;Collagen;cytokine;Data;Deposition;Deterioration;Development;drug discovery;Drug Targeting;effective therapy;effectiveness testing;Ensure;Extracellular Matrix;Extracellular Matrix Proteins;Family;Fingers;Functional disorder;Future;Genes;Genetic;genome wide association study;Homeostasis;Human;human disease;Human Pathology;In Vitro;in vivo;Individual;Infant;Infection;Inflammation;inhibitor;insight;Intranasal Administration;Knockout Mice;Laboratories;lentiviral-mediated;Ligase;Lung;Lung Diseases;Malignant Neoplasms;Mammals;Measures;Mediating;Mediator;Metabolic;Metabolism;microscopic imaging;Mitogens;Modeling;Molecular;mouse model;Mus;muscle form;Muscle function;Myofibroblast;Neonatal lung;Nerve Degeneration;new therapeutic target;novel;obstructive airway disease;overexpression;Oxidative Stress Pathway;Pathogenesis;Pathway interactions;Persons;Pharmaceutical Preparations;pharmacologic;Phenotype;Physiological;Physiology;PIK3CG gene;Play;prevent;Process;Production;Profibrotic signal;Proliferating;prophylactic;protein expression;protein protein interaction;Proteins;pulmonary function;Pulmonary Inflammation;Pulmonary Pathology;Pyroglyphidae;Regulation;Respiratory Signs and Symptoms;respiratory smooth muscle;Ring Finger Domain;Role;Scheme;School-Age Population;Signal Transduction;Signaling Molecule;Single Nucleotide Polymorphism;Small Interfering RNA;Smooth Muscle;Smooth Muscle Myocytes;Solid;Specificity;Symptoms;Testing;Transforming Growth Factors;ubiquitin ligase;ubiquitin-protein ligase;Ubiquitination;Up-Regulation;Wheezing

PROJECT_TITLE: E3 ubiquitin ligase RNF145 in airway smooth muscle functions and in asthma

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Biomedical Imaging;Clinical Research;Neurosciences;Patient Safety;Physical Injury - Accidents and Adverse Effects;Prevention;Rehabilitation;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_CITY: STANFORD

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE Degenerative cervical myelopathy (DCM) is the most common form of spinal cord injury in adults and causes worsening neurological dysfunction including hand weakness and diminished coordination. Surgical management of DCM is challenging due to the low diagnostic certainty of the underlying pathology and the lack of predictive factors to determine which patients may or may not improve. Here we aim to use advanced brain, spinal cord, and muscle magnetic resonance imaging techniques to fully characterize the mechanisms of hand dysfunction in DCM and then develop neuromuscular signatures of hand function that predict surgical outcomes in DCM.

PI_NAMEs: WEBER, KENNETH ARNOLD (contact)

PROGRAM_OFFICER_NAME: BAMBRICK, LINDA LOUISE

PROJECT_TERMS: Adult;Affect;Age;Architecture;Area;Atrophic;Brain;Cerebellum;Cervical;Cervical spine;Clinical;dexterity;Diagnostic;Diffusion;Early Intervention;Enrollment;Exposure to;Extensor;Fatty acid glycerol esters;Female;Fingers;Flexor;Forearm;Functional Magnetic Resonance Imaging;Goals;grasp;gray matter;Hand;hand dysfunction;Hand functions;hand rehabilitation;Hand Strength;Health;healthy volunteer;Image;Imaging Techniques;improved;Injury;Knowledge;Location;machine learning algorithm;Magnetic Resonance Imaging;male;Measures;Methods;morphometry;Motor;Motor Cortex;Motor Neurons;multidisciplinary;Muscle;Muscle denervation procedure;Neurobiology;Neurologic Dysfunctions;neuromuscular;neuromuscular system;Operative Surgical Procedures;Outcome;Participant;Pathology;Pathway interactions;Patients;Peripheral;predicting response;Predictive Factor;predictive signature;prevent;Property;Recovery;response;Rest;Risk;Schedule;Severities;sex;Signal Transduction;Spinal;Spinal Cord;spinal cord compression;Spinal Cord Diseases;Spinal cord grey matter structure;Spinal cord injury;Spine surgery;surgery outcome;Surgical Management;Technology;United States National Institutes of Health;Validation;Ventral Horn of the Spinal Cord;Water;white matter;Work

PROJECT_TITLE: MRI-Derived Neuromuscular Signatures to Predict Surgical Response in Degenerative Cervical Myelopathy

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Kidney Disease;Nutrition;Urologic Diseases

ORG_DEPT: UROLOGY

PHR: PROJECT NARRATIVE Meals containing high amounts of oxalate may induce urinary nanocrystals, stimulate immunity, and promote calcium oxalate kidney stone (CaOx KS) formation. This proposal will use human translational studies and experimental models to investigate the impact of dietary oxalate on nanocrystalluria, monocytes, and macrophages. Our ultimate goal is to identify therapeutic targets to enhance macrophage metabolism and clearance of CaOx crystals from the kidney.

PI_NAMEs: MITCHELL, TANECIA R (contact)

PROGRAM_OFFICER_NAME: KIRKALI, ZIYA

PROJECT_TERMS: Ablation;Adult;Affect;Anti-Inflammatory Agents;Automobile Driving;Bacterial Artificial Chromosomes;Bioenergetics;Calcium Oxalate;Cell Line;Cells;Chronic Kidney Failure;Classification;cohort;Consumption;Crossover Design;Crystal Formation;cytokine;Data;Deposition;Diabetes Mellitus;Diameter;Diet;dietary;Disease;Economic Burden;Excretory function;Experimental Models;Female;Food;Functional disorder;Gene Expression;Goals;Grant;Homeostasis;Human;Hypertension;IL10 gene;Immune;Immune response;Immunity;Impairment;In Vitro;in vivo Model;Individual;Inflammation;Ingestion;Injury;Injury to Kidney;insight;Intake;Interleukin-10;interleukin-10 receptor;Kidney;Kidney Calculi;Kidney Diseases;Laboratories;Leukocytes;Link;Macrophage;male;Measures;Mediating;Metabolism;meter;Methods;Minerals;Mitochondria;monocyte;Mus;nanocrystal;Nephrons;novel;novel strategies;Obesity;Oxalates;Oxidation-Reduction;Oxidative Stress;Pain;Patients;Persons;Phenotype;Plants;Prevalence;prevent;Prevention;Process;programs;Proline;Quality Control;Randomized;Reactive Oxygen Species;recruit;Recurrence;Reporter;Reporting;response;Risk;Role;Signal Pathway;Signal Transduction;Source;Study models;Supplementation;Testing;therapeutic target;tool;Transgenic Organisms;translational model;United States;urinary;Urine

PROJECT_TITLE: Oxalate-Driven Host Responses in Kidney Stone Disease

STUDY_SECTION: KUFD

STUDY_SECTION_NAME: Kidney and Urological Systems Function and Dysfunction Study Section[KUFD]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Eye Disease and Disorders of Vision

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: NORTHEASTERN UNIVERSITY

PHR: Project Narrative The purpose of the proposed work is to test the hypothesis that mechanical forces directly drive tissue assembly in corneal stromal matrix produced by human corneal cells. A sophisticated battery of mechanobiological tools will be combined to permit both local mechanical measurements and single molecule tracking while tissue is being elaborated in vitro. The results may change our understanding of how load-bearing tissues are made and could guide mechanotherapeutics for problems such as keratoconus, fibrosis, ectasia, myopia, glaucoma and even aid efforts at corneal stromal regeneration.

PI_NAMEs: RUBERTI, JEFFREY W (contact)

PROGRAM_OFFICER_NAME: MCKIE, GEORGE ANN

PROJECT_TERMS: Acceleration;Access to Information;Address;Animals;Biopolymers;blebbistatin;Cell Culture Techniques;Cells;Cicatrix;Collagen;Collagen Fibril;Communication;Connective Tissue;Cornea;corneal scar;Corneal Stroma;Coupled;Couples;Custom;Deposition;Development;Diffusion;Engineering;Environment;Etiology;Event;Exclusion;Experimental Designs;Extracellular Matrix;Eye;fibrillogenesis;Fibroblasts;Fibronectins;Fibrosis;Genetic;Glaucoma;Goals;Growth;Homeostasis;Human;Image;improved;In Vitro;Integrins;Intervertebral disc structure;Investigation;Keratoconus;Knowledge;Laser In Situ Keratomileusis;Length;Ligaments;light transmission;live cell microscopy;Measurement;Measures;mechanical force;mechanical signal;Mechanics;Medicine;member;Mesenchymal;Methods;Microscopy;Minor;Modeling;Molecular;molecular assembly/self assembly;monomer;Morphogenesis;Myofibroblast;Myopia;Natural regeneration;Nature;organizational structure;Pathologic;Pathological Dilatation;Pattern;Phase;Positioning Attribute;pressure;Production;prospective;Recording of previous events;regenerative;response;Retinal Detachment;Role;Sclera;Shapes;single molecule;Speed;Stress;Structure;temporal measurement;Tendon structure;Testing;theories;Tissue Engineering;Tissues;tool;Traction;Tunic;Vertebrates;Vision;Weight-Bearing state;Work;wound healing

PROJECT_TITLE: Mechanical Causation of Corneal Stromal Matrix Synthesis and Fibrosis

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]


NIH_SPENDING_CATS: Aging;Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Fetal Alcohol Spectrum Disorders (FASD);Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Social Determinants of Health;Substance Misuse

ORG_CITY: ATLANTA

ORG_DEPT: PSYCHIATRY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative In addition to physical, neurocognitive, physiological and behavioral abnormalities/deficits that occur following prenatal alcohol exposure (PAE), our findings in CIFASD 4 suggest negative impacts on both physical and mental health outcomes in midlife, with many health problems occurring earlier than would be expected in the general population. Findings also indicate that PAE is associated with long-lasting, adverse changes in immune and endocrine function, starting in infancy and lasting into adulthood. Using a “whole body, whole lifespan” approach, we will investigate how PAE-induced alterations in the immune and endocrine systems may be key drivers of early-onset health and functional deficits in adults with FASD.

PI_NAMEs: BODNAR, TAMARA SONIA;COLES, CLAIRE D. (contact)

PROJECT_TERMS: Adult;Affect;Age;alcohol exposure;angiogenesis;Behavioral;biomarker identification;Canada;Cells;Chronic;Coping Skills;Development;Disease;early life adversity;early onset;Endocrine;Endocrine system;Event;Fetal alcohol effects;Fetal Alcohol Exposure;Fetal Alcohol Spectrum Disorder;fetal programming;Functional disorder;functional outcomes;Gene Expression Profiling;General Population;Health;high risk;Immune;immune function;Immune system;Individual;infancy;Inflammation;Inflammatory;late life;Length;Life;Life Cycle Stages;Life Experience;life span;Link;Measures;Mental Health;Metabolic;Methodology;middle age;Nerve Degeneration;neurobehavioral;Neurocognitive;older adult;Older Population;Organism;Outcome;Pattern;Performance;physical conditioning;Physiological;Play;Predisposition;Quasi-experiment;Research;Resources;Risk;Role;Sampling;Series;Site;social adversity;social factors;social influence;System;telomere;Testing;vascular injury;Vulnerable Populations

PROJECT_TITLE: A Multisite Study of Prenatal Alcohol Exposure: Effects of Inflammation and Endocrine Dysfunction in Adulthood


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_CITY: ROCKVILLE

ORG_NAME: MESO SCALE DIAGNOSTICS, LLC

ORG_STATE: MD

PHR: Our objective is to develop better assays for measuring antibodies produced in people after influenza infection or vaccination. We’ll develop assays that measure total antibody responses, and assays that specifically measure the antibodies responsible for protection from infection. The assays will be faster and more practical than existing methods, and will provide important tools for accelerating the development of new influenza vaccines. †The sections on documents contained in this proposal that are marked with an asterisk contain proprietary/confidential information that MSD requests not be released to persons outside the Government, except for purposes of review and evaluation.

PI_NAMEs: SIGAL, GEORGE B (contact)

PROGRAM_OFFICER_NAME: ARNOLD, MICHELLE MARIE

PROJECT_TERMS: Acceleration;Address;Adenovirus Vector;Adopted;Animals;Antibodies;Antibody Diversity;Antibody Response;antibody test;Antigens;assay development;Assessment tool;Benchmarking;Biological;Biological Assay;Birds;Blocking Antibodies;Blood;Clinical;Clinical Research;commercialization;Community Developments;Confidential Information;COVID-19;COVID-19 vaccine;cross immunity;Cultured Cells;Detection;Development;Diagnostic;Epitopes;Erythrocytes;Evaluation;flexibility;flu;Government;Hemagglutination;Hemagglutinin;Human;Immune;Immune Evasion;Immune system;immunogenicity;Immunoglobulin A;Immunoglobulin G;Immunology;Immunology procedure;improved;Infection;Influenza;Influenza Hemagglutinin;influenza infection;Influenza vaccination;influenza virus vaccine;innovation;interest;Label;manufacture;Measurement;Measures;Messenger RNA;Methods;Michigan;Modality;Mutation;nanoparticle;next generation;novel vaccines;pandemic potential;Pathway interactions;performance tests;Persons;Phase;Preparation;Procedures;Process;product development;programs;Proteins;Protocols documentation;Qualifying;Quality Control;Reagent;Recombinants;research and development;respiratory;Respiratory Tract Infections;Running;Sampling;Serology test;sialic acid-binding lectin;Sialic Acids;Site;Streptococcus pneumoniae;success;technology platform;time use;tool;Translational Research;Update;Vaccination;vaccine development;vaccine effectiveness;vaccine trial;Vaccines;Validation;Viral;Virus Diseases;Work

PROJECT_TITLE: A Flexible High-Throughput Immunological Assay to Support Next-Generation Influenza Vaccine Studies


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Prevention

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE In this project, the applicant will identify novel features of the digital clock drawing test most correlated with pathophysiological events in preclinical Alzheimer’s disease (AD) using machine learning and multimodal neuroimaging and establish the longitudinal performance of the digital test. Outcomes of the project will provide a non-invasive assessment of individual cognitive status in the context of progressive pathophysiological events in preclinical AD. This will enable efficient and cost-effective participant screening for AD therapeutic trials and facilitate the translation of digital testing into AD primary care settings, especially for underserved populations.

PI_NAMEs: FU, FANG LU (JESSIE)  (contact)

PROGRAM_OFFICER_NAME: LUO, YUAN

PROJECT_TERMS: Accounting;Aging;Alzheimer disease screening;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease therapeutic;Alzheimer's disease therapy;Alzheimer’s disease biomarker;Amyloid beta-Protein;Area;Award;beta amyloid pathology;Biological;biological heterogeneity;Brain Diseases;clinical application;clinical diagnosis;clinical heterogeneity;clinically relevant;Cognitive;cognitive performance;cognitive testing;cost effective;deep learning;Deposition;Detection;Development;Diagnostic;digital;digital tool;Discrimination;Early Diagnosis;Elderly;entorhinal cortex;Event;FDA approved;feature selection;Functional disorder;Goals;Health;Heterogeneity;Hippocampus;Impaired cognition;improved;in vivo;indexing;Individual;Machine Learning;Magnetic Resonance Imaging;Measures;multimodal learning;multimodal neuroimaging;Neuropsychology;neurovascular;normal aging;novel;Outcome;Paper;Participant;Pathology;Performance;performance tests;Perfusion;Phase;Plasma;Positron-Emission Tomography;pre-clinical;primary care setting;Process;Reporting;Research;Research Personnel;Rest;skills;Sum;tau Proteins;Tauopathies;Techniques;Testing;Therapeutic Trials;Therapy trial;Thinness;Time;time use;Training;Training Activity;Translations;Underserved Population;uptake;Validation;White Matter Hyperintensity;Work

PROJECT_TITLE: Development and validation of efficient cognitive composite scores of digital tools for the detection of early pathophysiological changes in Alzheimers disease

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development Facilitating The Transition to Independence Study Section[AGCD-1]


ADMINISTERING_IC: DA

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Prevention;Social Determinants of Health;Substance Misuse;Substance Misuse Prevention

ORG_CITY: UNIVERSITY PARK

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

PHR: Project Narrative If science is to inform effective substance misuse prevention policy and ultimately improve public health, the field needs an effective strategy for directly supporting policymakers’ use of research evidence, yet our field lacks an evidence-based model designed for this purpose. Accordingly, we propose a state-level randomized controlled trial (N = 30 state legislatures) of a formal, theory-based approach for supporting policymakers’ use of scientific evidence that does not involve lobbying—the Research-to-Policy Collaboration (RPC) Model. This work can reduce population-level substance misuse by improving the use of scientific information in policymaking, thus increasing the availability of evidence-based prevention programs and policies.

PI_NAMEs: CROWLEY, DANIEL MAX (contact);SCOTT, JENNIFER TAYLOR

PROGRAM_OFFICER_NAME: GOLDSTEIN, AMY B

PROJECT_TERMS: Address;Adoption;Awareness;Behavior;Code;Collaborations;Communities;Complement;Data;effectiveness evaluation;effectiveness research;evidence base;experimental study;Family;Fostering;Frequencies;improved;Incentives;insight;Intervention;Interview;Language;Lobbying;Maps;model design;Modeling;Morbidity - disease rate;mortality;multilevel analysis;outreach;Perception;Policies;Policy Maker;Policy Making;Population;Prevention;Prevention program;Prevention Research;prevention service;Process;Productivity;Protocols documentation;Public Health;Publishing;Randomized, Controlled Trials;Research;Research Personnel;response;Schools;Science;Source;Statutes and Laws;substance misuse;substance misuse prevention;Surveys;Testing;theories;Time;time use;Translating;Voting;Work;Youth

PROJECT_TITLE: Building the Science of Evidence-Informed Prevention Policy: A Multi-level Model for Supporting Substance Misuse Prevention

STUDY_SECTION: CIHB

STUDY_SECTION_NAME: Community Influences on Health Behavior Study Section[CIHB]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Eye Disease and Disorders of Vision;Genetics;Neurosciences;Pediatric

ORG_CITY: CAMBRIDGE

ORG_NAME: HARVARD UNIVERSITY

PHR: Project Narrative We propose to develop a transformative multimodal experimental platform to uncover the brain-wide architecture of neuronal circuits underlying parenting behavior in molecular, functional, connectivity-based and computational terms. We will use this experimental framework to shed light into the sensory motor transformation underlying parenting behavior as a function of the animal sex and physiological state.

PI_NAMEs: DULAC, CATHERINE  (contact);MURTHY, VENKATESH N;ZHUANG, XIAOWEI

PROGRAM_OFFICER_NAME: DAVID, KAREN KATE

PROJECT_TERMS: 3-Dimensional;Address;Animals;Architecture;Area;Behavior;Behavior Control;Behavioral;behavioral outcome;behavioral response;Brain;Brain region;Calcium;cell type;Cells;Central Nervous System;Child Rearing;Collaborations;Complex;computer framework;Computer Models;Corpus striatum structure;Cues;Discipline;Fathers;Female;Fluorescent in Situ Hybridization;Functional Imaging;Gene Expression;Gene Expression Profile;Genetic Transcription;Hypothalamic structure;Image;imaging approach;Immediate-Early Genes;In Situ;Individual;Infant;innovation;Instinct;Investigation;Light;Machine Learning;male;Maps;Measures;Mediating;Methods;microendoscopy;Modality;model building;Modeling;Molecular;Motor;multi-photon;multimodality;neural;neural circuit;neuronal circuitry;Neurons;neuroregulation;Odorant Receptors;Odors;olfactory bulb glomeruli;Partner in relationship;Pattern;Peripheral Nervous System;Physiological;Population;predictive modeling;Preoptic Areas;Process;pup;Research Personnel;Resolution;Rodent;Sensory;sex;Shapes;Smell Perception;Stimulus;System;Technology;Testing;Thick;Tissues;tool;tool development;transcriptomics

PROJECT_TITLE: Systems-Level and in Situ Transcriptomics Deconstruction of Neural Circuits Underlying Sensorimotor Transformation in an Innate Behavior


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

ORG_CITY: SAN FRANCISCO

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Live cell therapies to intelligently and specifically treat human disease are the next frontier of medicine. These therapies will rely on engineered cells that are capable of understanding their environment and making autonomous decisions about when and where to deliver treatment. This project will uncover fundamental principles for how cells control their behavior based on their environment and will make important contributions to both basic biology and the engineering of next generation therapeutics

PI_NAMEs: WEINBERG, ZARA  (contact)

PROGRAM_OFFICER_NAME: STOKES, KALYNDA K

PROJECT_TERMS: Advocacy;Behavior;Biological Models;Biology;Biosensor;cell behavior;Cell Maintenance;Cell model;Cell Physiology;Cell Shape;Cell Therapy;cell type;Cells;Cellular biology;cellular engineering;Computer Models;Cyclic AMP;Data;Development;Developmental Biology;differentiation in vitro;Disease;Educational process of instructing;Embryo;embryonic stem cell;Engineering;Environment;Epiblast;epigenomics;equity, diversity, and inclusion;experience;Fishes;frontier;Future;Genetic;Genetic Transcription;Genomics;Goals;Health;Hour;Human;human disease;information processing;insight;Ions;Justice;Maintenance;Mediating;Medicine;Mentors;Mentorship;Methods;Mitogens;Modeling;Modification;Morphology;Mouse Embryonic Stem Cells;Mus;Neurosciences;non-genetic;novel;novel therapeutics;optogenetics;Pathway interactions;Phosphotransferases;Physiological;Physiology;pluripotency;Positioning Attribute;predictive modeling;prevent;Production;programs;Proliferating;Proteomics;Regulation;Reporter;Research;response;Role;screening;Signal Pathway;Signal Transduction;small molecule;spatiotemporal;Specificity;stem cells;Stimulus;synthetic biology;System;Tissues;tool;Training;transcription factor;transcriptomics;Transgenes;Whole Organism;Work;Zebrafish

PROJECT_TITLE: Understanding and rewiring cellular behavior with synthetic biology approaches


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Autoimmune Disease;Brain Disorders;Dementia;Digestive Diseases;Inflammatory Bowel Disease;Microbiome;Neurodegenerative;Neurosciences

ORG_CITY: GRAND FORKS

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF NORTH DAKOTA

ORG_STATE: ND

PHR: Narrative Alzheimer’s disease (AD) is a devastating age-related neurodegenerative disorder that causes extensive deterioration of cognitive functions. Altered gut bacteria and their effects on the gut, immune system, and brain have been recently implicated as causative in disease. The IgA isotype antibody produced predominantly in the gut is the primary protection in the intestine from harmful pathogens such as bacteria. Using a mouse model of disease, we demonstrate that female AD mice have elevated IgA in the intestine that recognizes unique disease- associated bacteria capable of producing memory dysfunction. We hypothesize that these IgA coated bacteria are directly contributing to disease in particularly females and will test this in the proposal. Completion of the study will identify pathogenic gut bacteria contributing to AD progression in a sex-selective fashion.

PI_NAMEs: NOOKALA, SUBA  (contact)

PROGRAM_OFFICER_NAME: MARIC, MAJA

PROJECT_TERMS: 16S ribosomal RNA sequencing;absorption;Address;Age;age related neurodegeneration;Alzheimer's Disease;Alzheimer's disease model;American;Amyloid;Amyloid beta-Protein;Antibodies;APP-PS1;Appearance;Attenuated;Awareness;Bacteria;Behavior;behavior change;Behavioral;Binding;Biochemical;Biological Markers;Blood;Brain;Burkholderiaceae;C57BL/6 Mouse;Chemosensitization;Clinical;cognitive function;Crohn's disease;cytokine;Data;Deterioration;diagnostic biomarker;Disease;disease model;Disease Progression;dysbiosis;Enteral;Environmental Risk Factor;Epithelium;Etiology;Family;Female;Functional disorder;Future;Genetic;Genotype;Gliosis;gut bacteria;gut inflammation;gut microbiota;gut-brain axis;Health;Histologic;Immune;Immune system;Immunoglobulin A;Immunologics;immunoregulation;Impairment;Individual;Inflammatory;Inflammatory Bowel Diseases;Inflammatory Response;innovation;Interdisciplinary Study;intestinal epithelium;intestinal homeostasis;Intestines;Investigation;male;Memory;Memory impairment;Meninges;microbial;Monitor;mouse model;Mus;Nerve Degeneration;neuropathology;novel strategies;Oral;Outcome;pathogen;pathogenic bacteria;Pathogenicity;Pathologic;Pattern;Peripheral;Permeability;Phenotype;Population;prevent;receptor;Reporting;Role;Secretory Immunoglobulin A;sex;Sex Differences;Signal Transduction;Sorting;Spleen;stool sample;Streptococcaceae;System;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;Time;tool;Toxin;Transgenic Mice;Transgenic Organisms;Transplantation;Ulcerative Colitis;United States;Wild Type Mouse;Work

PROJECT_TITLE: Role of IgA-biome in intestinal dysbiosis and brain changes in Alzheimer's disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AN-Z(55)R]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Lung;Neurosciences;Opioids

ORG_CITY: GAINESVILLE

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: PROJECT NARRATIVE The larynx plays a pivotal role in protection of the lungs from aspiration and subsequent pneumonia. Opioid use is associated with impairment in the function of the larynx to protect the lungs from aspiration. Further, opioids are often prescribed to older adults who are particularly at risk of developing aspiration pneumonia due to impairments in airway protection.

PI_NAMEs: BOLSER, DONALD C (contact);MORRIS, KENDALL FRANCIS;PITTS, TERESA G

PROGRAM_OFFICER_NAME: LAPOSKY, AARON D

PROJECT_TERMS: adduct;aspirate;Aspiration Pneumonia;Behavior;Big Data;Cells;Chemical Stimulation;Clinical;Data;data modeling;Death Rate;Electric Stimulation;Elements;Functional disorder;Goals;Impairment;Ingestion;insight;Interneurons;Investigation;Ipsilateral;Knowledge;Larynx;Lung;Mechanical Stimulation;Mechanics;Mediating;Modeling;models and simulation;Motor;Motor Neurons;Movement;Muscle hypotonia;neural network;neurogenesis;Neuromechanics;Neurons;Neuropharmacology;Nucleus solitarius;older adult;Opioid;Opioid agonist;opioid use;Organ;Outcome;Pathway interactions;Pattern;Peripheral;Pharmaceutical Preparations;Play;Pneumonia;predictive modeling;prevent;Production;protective behavior;Reflex action;Regulation;resilience;respiratory;response;Reticular Formation;Risk;Role;Sensory;Site;System;Techniques;Trachea;translational pipeline;vocal cord

PROJECT_TITLE: Central and Peripheral Regulation of Laryngeal Adduction

STUDY_SECTION: MFSR

STUDY_SECTION_NAME: Motor Function, Speech and Rehabilitation Study Section[MFSR]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Brain Disorders;Clinical Research;Dementia;Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Patient Safety

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE Severe delirium, a type of acute confusion often experienced by older adults, leads to worsening Alzheimer’s Disease and related Dementias and quality of life. Healthcare clinicians need a more timely and comprehensive measurement of severe delirium in critically ill older adults. Therefore, the current study aims to develop a passive digital marker for measuring delirium severity that relies on routinely collected data and then tests if this passive digital marker is usable and acceptable by frontline healthcare clinicians.

PI_NAMEs: LINDROTH, HEIDI  (contact)

PROGRAM_OFFICER_NAME: ROBERTS, LUCI

PROJECT_TERMS: Acceleration;Active Learning;Activities of Daily Living;Acute;Address;Admission activity;adverse outcome;Alzheimer's disease related dementia;Alzheimer's disease risk;Artificial Intelligence;Brain;career;career development;Caring;Cessation of life;Clinic;Clinical;clinical care;clinical decision-making;Clinical Informatics;Clinical Nurse Specialists;Clinical Trials Unit;Cognition;cohort;computer generated;Computer Vision Systems;Confusion;Conscious;convolutional neural network;Critical Illness;Data;Data Science;Decision Making;Delirium;dementia burden;dementia risk;design;Development;Development Plans;digital;Digital biomarker;digital video recording;Effectiveness;Electronic Health Record;evidence base;Evidence based treatment;experience;Extramural Activities;Failure;Feedback;Funding;Future;Goals;Grant;Healthcare;Hospitalization;Hour;human old age (65+);Impaired cognition;improved;Informatics;Institutionalization;Intensive Care Units;International;Intervention;K-Series Research Career Programs;Knowledge;Laboratories;Measurement;Measures;Mechanical ventilation;Medical;Mentored Patient-Oriented Research Career Development Award;Mentorship;Monitor;mortality;National Institute on Aging;novel;older adult;Outcome;Participant;Pathway interactions;Patients;Performance;Postdoctoral Fellow;primary outcome;prospective;Quality of Care;Quality of life;Randomized;Randomized Controlled Clinical Trials;recruit;Research;Research Project Grants;Research Proposals;research study;Risk;Risk Reduction;Scientist;sensor;Severities;skills;support tools;System;Technology;temporal measurement;Testing;Time;tool;Training;treatment as usual;usability;Work;Workload;Writing

PROJECT_TITLE: Harnessing the Power of Technology to Transform Delirium Severity Measurement in the ICU

STUDY_SECTION_NAME: Career Development for Clinicians/Health Professionals Study Section [AGCD-3]


NIH_SPENDING_CATS: Autoimmune Disease;Complementary and Integrative Health;Digestive Diseases;Inflammatory Bowel Disease;Microbiome

ORG_CITY: SAN DIEGO

ORG_DEPT: BIOLOGY

ORG_NAME: SAN DIEGO STATE UNIVERSITY

PHR: Project Narrative: An imbalance of certain bacterial groups within the human gut is associated with diseases such as obesity and inflammatory bowel disease, however, we lack a mechanistic understanding of these associations. This project will determine how human gut bacteria interact with their host by producing a previously undescribed syringe-like structure that promotes interactions by injecting proteins into target cells. Our results will lay a foundation for technology employing microbiome bacteria and their syringe-like structures as probiotics to modulate the human microbiome and host health.

PI_NAMEs: SHIKUMA, NICHOLAS J (contact)

PROGRAM_OFFICER_NAME: KEANE-MYERS, ANDREA

PROJECT_TERMS: Adult;Amoeba genus;Area;Bacteria;Bacteroides;Binding;Cadherins;Cells;Cryo-electron tomography;Development;Disease;Equilibrium;Eukaryotic Cell;Europe;experimental study;Family;fecal transplantation;Fiber;Fluorescence Microscopy;Foundations;gut bacteria;gut microbiome;Health;Health Promotion;host-microbe interactions;Human;Human Cell Line;Human Microbiome;improved;In Vitro;Inflammatory Bowel Diseases;Inflammatory Response;Injections;Insecta;invertebrate host;Investigation;Knowledge;Laboratories;Link;Mediating;microbiome;Obesity;Organism;Probiotics;Proliferating;Proteins;response;Structure;Structure-Activity Relationship;Syringes;System;Technology;United States;Work

PROJECT_TITLE: Examining a Unique Contractile Injection System Mediating Host-Microbe Interactions

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-GGG-X(55)R]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Nutrition;Prevention;Social Determinants of Health

ORG_CITY: HADLEY

ORG_NAME: UNIVERSITY OF MASSACHUSETTS AMHERST

PHR: Project Narrative This study proposes to conduct a fully powered cluster randomized controlled trial of a novel, integrated urban gardens and peer nutritional counseling intervention (ProMeSA) to support the goal of improving ART adherence, HIV care retention, and HIV virologic suppression (undectectable viral load). The study will involve 20 HIV clinics and 500 people with HIV and food insecurity in the Dominican Republic and will assess intervention efficacy on HIV clinical outcomes; examine intermediate outcomes (food security, diet quality, HIV stigma, and competing needs) posited to mediate the impact of ProMeSA on ART adherence, HIV care retention, and HIV viral suppression; and explore barriers and facilitators to intervention uptake, implementation, and sustainability.

PI_NAMEs: DEROSE, KATHRYN PITKIN (contact);PALAR, KARTIKA

PROGRAM_OFFICER_NAME: STIRRATT, MICHAEL JAMES

PROJECT_TERMS: Address;Adherence;Affect;Agriculture;antiretroviral therapy;Behavioral;Body fat;Body mass index;burden of illness;California;care outcomes;Caribbean region;Caring;Cause of Death;Clinic;Clinic Visits;Clinical;Communities;comparison control;Consumption;cost;Counseling;Country;Data;Diet;Dietary Intervention;Dissemination and Implementation;Dominican;Dominican Republic;Economic Burden;efficacy evaluation;experience;follow-up;Food;food insecurity;food security;Future;Goals;Grant;Health;HIV;HIV/AIDS;Household;implementation intervention;improved;International;Interruption;Intervention;intervention effect;Latin America;Massachusetts;Mediating;Mediator;medical attention;Mental Depression;Mental Health;novel;Nutritional;Nutritional status;Nutritive Value;Outcome;Participant;Pathway interactions;Patient Self-Report;peer;Personal Satisfaction;Persons;physical conditioning;Pilot Projects;Prevalence;primary outcome;Process;programs;psychosocial;Public Health;Randomized;Randomized, Controlled Trials;Research Personnel;resilience;Resource-limited setting;Resources;Role;San Francisco;scale up;secondary outcome;social;social stigma;Spanish;success;therapy adherence;treatment as usual;Treatment Efficacy;Treatment outcome;United Nations;Universities;uptake;Vegetables;Viral;Viral Load result;Work

PROJECT_TITLE: Promesa: Urban gardening and peer nutritional counseling to improve HIV care outcomes among people with food insecurity in the Dominican Republic

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Conditions Affecting the Embryonic and Fetal Periods;Disability Research;Dissemination and Implementation Research;Fetal Alcohol Spectrum Disorders (FASD);Intellectual and Developmental Disabilities (IDD);Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Substance Misuse;Telehealth

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: Project Narrative Most people with fetal alcohol spectrum disorders (FASD) cannot access FASD-informed interventions and experience lower quality of life. This project will develop and evaluate three developmentally-appropriate FASD-informed interventions targeting quality of life at a different life phase. Each intervention leverages technology to increase accessibility and overcome significant barriers to care.

PI_NAMEs: PETRENKO, CHRISTIE LYNN MCGEE (contact);TAPPARELLO, CRISTIANO

PROGRAM_OFFICER_NAME: DUNTY, JR, WILLIAM

PROJECT_TERMS: Address;Adolescence;Adolescent;Adoption;Adult;Age;arm;Attention;Awareness;barrier to care;care outcomes;Caregivers;Caring;Child;Child Care;Child Rearing;Childhood;Client;Clinical;Communities;Community Healthcare;community setting;comparison group;Competence;Consolidated Framework for Implementation Research;dashboard;Development;Developmental Disabilities;Diagnosis;effectiveness evaluation;effectiveness measure;effectiveness testing;efficacy trial;evidence base;experience;Family;Fetal Alcohol Spectrum Disorder;fetal diagnosis;Focus Groups;Foundations;Future;Geographic Locations;Glean;Health;Health Personnel;implementation framework;implementation outcomes;improved;improved outcome;Individual;Infrastructure;innovation;Institution;Intervention;intervention effect;Intervention Studies;Interview;Knowledge;Life;life span;Literature;Maintenance;Maps;Mediating;Mental Health;Methodology;Methods;mhealth interventions;Mobile Health Application;multidisciplinary;novel diagnostics;Outcome;Outcome Measure;Participant;patient population;Pattern;Persons;Phase;Policies;Positioning Attribute;Process;Provider;Public Health;Quality of life;Randomized, Controlled Trials;recruit;Research;research clinical testing;Research Personnel;Resources;screening;Self Determination;Self Direction;Self Efficacy;Site;skills;Social Environment;social stigma;Staff Development;success;System;system-level barriers;Technology;technology intervention;Testing;theories;therapy development;three-arm study;Training;trial design;usability;user centered design;Vision;Waiting Lists;Work

PROJECT_TITLE: Leveraging Technology to Increase Quality of Life for FASD Across the Lifespan


ADMINISTERING_IC: AR

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: CHAPEL HILL

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: RELEVANCE TO PUBLIC HEALTH While stroke patients experience dramatic bone loss and high rates of bone fracture not explained by bedrest alone, the underlying causes remain largely unknown. Microdevices are uniquely qualified to mimic 3D microenvironments in a highly controllable manner, allowing localized effects of bone-vascular pathologies at the cellular level to be isolated from confounding systemic effects present in vivo. This research will leverage microdevice technology to investigate changes to bone cell behavior in response to chronic inflammatory conditions following stroke, providing key insights into a potential initiator of bone loss that can inform better treatment strategies to improve bone health for stroke survivors.

PI_NAMEs: STANGELAND-MOLO, SANDRA JEANNE (contact)

PROGRAM_OFFICER_NAME: MARQUITZ, ARON

PROJECT_TERMS: 3-Dimensional;Acceleration;Address;Adult;Affect;Aging;Alkaline Phosphatase;Apoptosis;Arthritis;Automobile Driving;Bed rest;Behavior;Biological Assay;biomaterial compatibility;Biomimetics;Blood Vessels;bone;bone cell;bone fragility;bone health;bone loss;bone mass;Bone Matrix;Bone remodeling;bone scaffold;Cardiovascular Diseases;cell behavior;Cell Communication;Cell Culture Techniques;Cell Maintenance;Cells;Cellular Morphology;Cessation of life;Chitosan;Chronic;clinical decision-making;Clinical Research;Collagen;comorbidity;Complex;Computer Models;crosslink;cytokine;cytotoxicity;density;Deposition;Devices;Dextrans;Electron Microscopy;Endothelial Cells;Endothelium;Environment;Enzyme-Linked Immunosorbent Assay;Event;experience;Exposure to;extracellular;Extracellular Matrix;fabrication;fluorescence imaging;Fracture;fracture risk;Gait abnormality;Gene Expression;Genetic Diseases;Geometry;Goals;Height;Hematopoietic;Human;improved;In Vitro;in vivo;Individual;Inflammatory;inflammatory milieu;Inflammatory Response;insight;Interferon Type II;Interferons;Interleukin-1 beta;Interleukin-6;Interleukins;Investigation;Ischemia;Ischemic Stroke;Label;Liquid substance;Long term disability;Maintenance;manufacture;mechanical load;mechanical properties;Mechanics;microdevice;mineralization;Minerals;Modeling;mortality;Mus;nanoindentation;Nitric Oxide;novel;Nutrient;organ on a chip;Osteoblasts;osteoclastogenesis;paracrine;Paracrine Communication;Pathology;Patients;Permeability;Persons;Pharmacologic Substance;Physiologic calcification;Porosity;post stroke;Production;programs;Property;Protein Secretion;Public Health;Qualifying;Radiation;Regulation;Research;response;Reverse Transcription;scaffold;Sensorimotor functions;Serum;Signal Transduction;Spectroscopy, Fourier Transform Infrared;Stroke;stroke patient;stroke survivor;TdT-Mediated dUTP Nick End Labeling Assay;Techniques;Technology;Tight Junctions;Tissues;Training;treatment strategy;United States;Vascularization;Work;X ray spectroscopy

PROJECT_TITLE: Developing a Novel Vascularized Bone Microdevice for Investigating the Post-Stroke Bone Microenvironment


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Epilepsy;Mental Health;Neurodegenerative;Neurosciences;Sleep Research

ORG_CITY: DAVIS

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Project Narrative In the United States, as many as 3 million individuals with epilepsy experience cognitive and sleep problems, in addition to seizures, contributing to poor quality of life. This project will characterize the sleep architecture patterns in epilepsy that are associated with memory and attention deficits. The long-term goal of this project is to develop therapeutic interventions for sleep disorders and cognitive deficits in people with epilepsy.

PI_NAMEs: OYEGBILE-CHIDI, TEMITAYO  (contact)

PROGRAM_OFFICER_NAME: REZAIZADEH, KAVON PAUL

PROJECT_TERMS: Academy;Acoustic Stimulation;Address;Adult;Anticonvulsants;Attention;Attentional deficit;Award;Behavior;Biological Markers;Childhood;Chronic;Clinical Trials Design;Cognition;Cognitive;Cognitive deficits;cognitive development;cognitive enhancement;cognitive function;cognitive performance;comorbidity;comparison control;Coupled;Coupling;Crossover Design;Data;density;Development;Disease;Electroencephalography;Epilepsy;epileptiform;Exhibits;experience;Functional Magnetic Resonance Imaging;Goals;high risk;Impairment;improved;Individual;Interruption;Intervention;Intervention Trial;Knowledge;Learning;Link;low socioeconomic status;Measures;Medicine;Memory;memory consolidation;Memory impairment;memory recall;Mentored Patient-Oriented Research Career Development Award;Mentors;Monitor;National Institute of Neurological Disorders and Stroke;neural network;Newly Diagnosed;non rapid eye movement;novel;older adult;Participant;Patients;Pattern;Performance;Persons;Pharmaceutical Preparations;Phase;Physicians;Polysomnography;poor sleep;Public Health;Quality of life;Randomized;Research;Research Priority;Scalp structure;Schools;Scientist;Seizures;skills;Sleep;sleep abnormalities;Sleep Architecture;Sleep Disorders;Sleep disturbances;Sleep Fragmentations;sleep pattern;sleep physiology;sleep spindle;sustained attention;Techniques;Temporal Lobe;Temporal Lobe Epilepsy;Testing;Therapeutic Intervention;Time;Training;Underemployment;United States;young adult

PROJECT_TITLE: Characterizing Sleep Signatures and its effects on Cognition in New-Onset Temporal Lobe Epilepsy

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-1 Study Section[NST-1]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Depression;Genetics;Mental Health;Mental Illness;Pediatric;Prevention;Social Determinants of Health

PHR: NARRATIVE: In this application, we propose to examine the relationship between experiences of family- and community-level promotive factors, exposure to childhood adversity, DNA methylation, and risk for depressive symptoms within two established and distinct longitudinal studies: (1) the Avon Longitudinal Study of Parents and Children (ALSPAC); and (2) the Fragile Families and Child Wellbeing Study (FFCWS). Findings from this research will help identify not just windows of vulnerability when childhood adversity and DNAm changes are most harmful, but also windows of opportunity when enriching family- level caregiving environments and community-level resources may be more impactful. Our findings will aid in identifying potentially modifiable targets for intervention that could be deployed to promote positive adaptation and reduce risk for depression across the life course for all people, including among those who have experienced childhood adversity.

PI_NAMEs: DUNN, ERIN CATHLEEN (contact)

PROGRAM_OFFICER_NAME: MEINECKE, DOUGLAS L

PROJECT_TERMS: Adolescence;Adult;Age;Biological;Biological Process;Birth;Brain;Buffers;Candidate Disease Gene;caregiving;Cell Culture Techniques;Child;child depression;Child Rearing;Child Welfare;Childhood;childhood adversity;cohort;Communities;community-level factor;Consensus;Data;Data Set;depressive symptoms;Development;diagnostic biomarker;Disease;DNA;DNA Methylation;early experience;early life adversity;Environment;Epigenetic Process;epigenome;ethnic diversity;Ethnic Origin;experience;experimental study;Exposure to;Family;Gene Expression;Genes;Genetic;Genome;genome-wide;grandparent;Human;in silico;in vivo;Influentials;innovation;insight;Intervention;Life;Life Cycle Stages;Life Experience;Link;Longitudinal Studies;Measures;Mediating;Mediation;Mental Depression;Mental Health;Methods;methylation pattern;Modeling;Modification;Molecular;multidimensional data;Neighborhoods;Outcome;Parents;Pathway interactions;Pattern;peer;peer support;Personal Satisfaction;Persons;phenotypic data;population based;Population Group;postnatal;prevent;promote resilience;protective effect;protective factors;Race;racial diversity;Recording of previous events;Research;Research Design;resilience;Resources;Risk;Risk Factors;Risk Reduction;Schools;sex;Shapes;Social support;Socioeconomic Status;Structure;Symptoms;Testing;Time;tool;Umbilical Cord Blood;Variant;Work;young adult;Youth

PROJECT_TITLE: Childhood adversity, DNA methylation, and risk for depression: A longitudinal study of protective factors and sensitive periods in development

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Genetics;Human Genome;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_DEPT: CHEMISTRY

PHR: Project Narrative There is significant interest in therapeutically targeting chromatin complexes for cancer treatment, yet the precise molecular mechanisms driving aberrant epigenetic states remain unclear. To interrogate the function of chromatin complexes, we are leveraging multi-disciplinary approaches that combine chemical biology with functional genomics, specifically focusing this application on lysine-specific histone demethylase-1 (LSD1) and its interactions with transcription factors and E3 ubiquitin ligases. Our studies will provide deep insight into chromatin complex structure and function as they relate to disease mechanisms and drug action.

PI_NAMEs: LIAU, BRIAN  (contact)

PROGRAM_OFFICER_NAME: COUCH, JENNIFER A

PROJECT_TERMS: Active Sites;Address;Agreement;Alleles;anti-cancer therapeutic;Automobile Driving;base editing;Binding;Biochemical;Biological Assay;Biology;biophysical analysis;cancer therapy;Cellular biology;chemical genetics;Chemicals;Childhood Brain Neoplasm;ChIP-seq;Chromatin;Complex;Data;Development;Disabling;Disease;DNA Binding;drug action;drug discovery;drug mechanism;Drug Modelings;Drug Modulation;Drug Targeting;Drug usage;Enhancers;Epigenetic Process;epigenome;epigenomics;Feedback;functional genomics;Gene Expression;genetic approach;genetic corepressor;Genetic Engineering;Genetic Transcription;Genome;genome-wide;Genomic approach;GFI1B gene;Glues;Goals;Growth;HDAC1 gene;histone demethylase;human disease;Induced Mutation;inhibitor;innovation;insight;interdisciplinary approach;interest;Knowledge;Link;live cell microscopy;Lysine;Lysine Degradation Pathway;Malignant Neoplasms;Maps;Mediating;Medulloblastoma;medulloblastoma cell line;Modality;Modeling;Molecular;Molecular Biology;mouse model;mutant;Mutate;Mutation;neoplastic cell;novel therapeutic intervention;Oncogenes;Oncology;overexpression;Pathway interactions;Pharmaceutical Preparations;pharmacologic;Phenocopy;Process;protein degradation;reconstitution;Recurrence;Regulation;Reporting;resistance allele;Resolution;Role;Site;small molecule;structural biology;Structure;Testing;Therapeutic;therapeutic target;transcription factor;transcriptome sequencing;tumor;tumorigenesis;ubiquitin-protein ligase;Up-Regulation;Work

PROJECT_TITLE: Chemical Genetic Approaches to Study Chromatin Complexes

STUDY_SECTION: SBCB

STUDY_SECTION_NAME: Synthetic and Biological Chemistry B Study Section[SBCB]