NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Physical Injury - Accidents and Adverse Effects;Prevention;Social Determinants of Health;Substance Misuse;Violence Against Women;Violence Research;Women's Health Research

ORG_CITY: DETROIT

ORG_NAME: WAYNE STATE UNIVERSITY

ORG_STATE: MI

PHR: Project Narrative Sexual assault occurs at extremely high rates and more than half involve alcohol consumption. The goal of the proposed research is to develop a virtual reality simulation of a potential sexual assault situation and use it in experimental research. This will allow the effects of alcohol consumption on sexual aggression to be examined under controlled conditions, thereby increasing confidence that differences found between drinkers and nondrinkers are due to alcohol, not other factors.

PI_NAMEs: ABBEY, ANTONIA  (contact);SMITH, KENNETH SCOTT

PROJECT_TERMS: 3-Dimensional;Acquaintances;Acute;Affect;Affective;Alcohol consumption;alcohol effect;alcohol involvement;Alcohols;Anger;Behavior;behavioral response;Black race;breath alcohol measurement;Cognition;Cognitive;cognitive interview;Companions;Cues;Decision Making;design;Development;Environment;Ethics;Etiology;evidence base;experimental study;Exposure to;Feedback;Feeling;Female;Focus Groups;Future;Goals;Grant;Group Interviews;head mounted display;insight;interest;Intervention;Intoxication;Laboratories;Laboratory Study;Life;male;men;modifiable risk;Nature;new technology;Participant;Patient Self-Report;Perception;perpetrators;Population;Prevention;Procedures;protective factors;Proxy;Randomized;Research;response;Risk Factors;Role;sex;sexual aggression;Sexual Arousal;sexual assault;sexual violence;simulation;sobriety;social situation;Surveys;technology development;two-dimensional;Update;violence against women;virtual reality;virtual reality environment;virtual reality simulation;virtual world;Woman

PROJECT_TITLE: Alcohol's Effects on Affective, Cognitive, and Behavioral Responses in a Virtual Reality Dating Simulation

STUDY_SECTION: ARM

STUDY_SECTION_NAME: Addiction Risks and Mechanisms Study Section[ARM]


ADMINISTERING_IC: DK

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences;Nutrition;Obesity

ORG_CITY: PHILADELPHIA

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PSYCHIATRY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Relevance: Project summary: Relevance to public health. New basic science discoveries show that pharmaceutical manipulation of the hormone amylin holds promise as a potential treatment for obesity, as food intake is suppressed by amylin in obese humans and animal models. This proposal will advance knowledge of amylin action on reward-based feeding that significantly contributes to the obesity epidemic. Proposed studies identify the physiological role of amylin action throughout the brain and the mechanisms by which amylin signaling reduces reward-based feeding.

PI_NAMEs: HAYES, MATTHEW R (contact)

PROGRAM_OFFICER_NAME: COOKE, BRAD

PROJECT_TERMS: 3-Dimensional;Acute;Adult;Affect;Agonist;amylin receptor;Animal Model;Animals;antagonist;Appetite Depressants;Basic Science;Behavior Control;Behavioral;Body Weight;Brain;Brain Stem;Calcitonin Receptor;Calcium;calcium indicator;Cell Nucleus;Cells;Chronic;Complex;Consumption;Cues;Development;discounting;Dopamine;Dopamine D1 Receptor;Dopamine D2 Receptor;Dorsal;DRD2 gene;Eating;Economic Burden;experience;experimental study;feeding;Fiber;Fluorescent in Situ Hybridization;Food;food consumption;Future;G-Protein-Coupled Receptors;gamma-Aminobutyric Acid;Genetic Transcription;genomic platform;Health;Hormones;human model;Impulsivity;in vivo;innovation;Intake;islet amyloid polypeptide;knock-down;Knowledge;Lateral;Learning;Manuscripts;Measures;Mediating;Metabolic;Modeling;motivated behavior;Motivation;neural;Neuroanatomy;neurochemistry;Neurons;neuroregulation;Nucleus Accumbens;Obesity;Obesity Epidemic;obesity treatment;Overweight;Pharmacologic Substance;Pharmacotherapy;Phenotype;Photometry;Physiological;Population;Psychological reinforcement;Public Health;Rat Transgene;Rattus;Receptor Activation;Receptor Signaling;reduced food intake;response;Rewards;Role;Satiation;selective expression;Self Administration;Series;Signal Transduction;Site;small hairpin RNA;Structure of area postrema;System;Testing;Time;transcriptomics;Ventral Tegmental Area;Viral;Weight Gain;Work

PROJECT_TITLE: Amylin modulates food reward


ADMINISTERING_IC: HL

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Genetics;Heart Disease

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

PHR: PROJECT NARRATIVE There is estimated to be 5.7 million adults in the US suffering from heart failure (HF), representing a significant health care burden for the nation. The progressive cardiac fibrosis and dysfunction seen in HF involves myofibroblast differentiation, with recent data showing myofibroblast differentiation to be driven by discrete changes in fibroblast metabolism. Understanding metabolic processes involved in myofibroblast differentiation will expand the application of new medicines that modulate these processes and ultimately lessen the burden of HF.

PI_NAMEs: LAZAROPOULOS, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: CHEON, YEWON

PROJECT_TERMS: Acetate-CoA Ligase;Acetyl Coenzyme A;Acetylation;Adult;Agreement;Anabolism;antagonist;Antibodies;ATP Citrate (pro-S)-Lyase;Automobile Driving;Biochemical;Biological Assay;Biological Availability;Cardiac;Cell Differentiation process;Cell Lineage;Cessation of life;Chromatin;chromatin immunoprecipitation;chromatin remodeling;Chronic;Clinical;cofactor;coronary fibrosis;Coupled;Data;demethylation;Deposition;Development;Enzymes;Epigenetic Process;epigenetic regulation;extracellular;Extracellular Matrix;Family member;Fibroblasts;Fibrosis;Functional disorder;Gene Expression;Gene Silencing;Genes;Genetic;Genetic Transcription;Glucose;Glycolysis;healthcare burden;Heart;Heart failure;Heart Injuries;Histologic;Histone Acetylation;histone acetyltransferase;Histones;Impairment;in vivo;in vivo evaluation;inducible Cre;Inflammation;Injury;interstitial;ischemic injury;Label;Lysine;Mediating;Medicine;Metabolic;Metabolic Pathway;Metabolism;metabolomics;Modeling;Modification;Molecular;Mus;Myocardial;Myocardial dysfunction;Myofibroblast;new therapeutic target;next generation sequencing;novel;Oxygen;Palmitates;Pathway interactions;permissiveness;pharmacologic;Phenotype;Population;prevent;Process;Production;programs;promoter;Regulation;Reporter;response;Role;Rupture;Testing;Transcriptional Activation;transcriptome sequencing;Ventricular;Vision

PROJECT_TITLE: The Role of Acetyl-CoA Metabolism in Epigenetic Regulation of Myofibroblast Differentiation


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Health Services;Kidney Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Rare Diseases

ORG_CITY: CLEVELAND

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative Renal cell carcinoma (RCC) is the most common malignant renal neoplasm, which often presents as an incidentally detected, incompletely characterized renal mass. Due to the limited capability of current imaging techniques, many of these patients with incidental renal mass undergo direct surgery or biopsy without further imaging evaluation which adds to unnecessary morbidity and health care cost. In this study, we propose to leverage our expertise in Magnetic Resonance Fingerprinting, machine learning, and body MR imaging to develop a novel free-breathing, multi-parametric MR imaging technique, which upon successful development, could make MRI a more powerful tool for the diagnosis and characterization of these patients with incidental renal mass, with the ultimate goal to eliminate unnecessary biopsy/surgery in eligible patients and provide guidance towards the most appropriate treatment strategy.

PI_NAMEs: CHEN, YONG  (contact);TIRUMANI, SREE HARSHA

PROGRAM_OFFICER_NAME: KIM, BOKLYE

PROJECT_TERMS: 3-Dimensional;Abdomen;Acceleration;Adoption;Affect;Angiomyolipoma;Benign;Biological;biological heterogeneity;Biological Markers;Biopsy;Breathing;Cellularity;Cessation of life;Chromophobe Renal Cell Carcinoma;Clear cell renal cell carcinoma;Clinical;clinical practice;Collagen;comorbidity;convolutional neural network;cost;Data;data acquisition;Databases;deep learning;Development;Diagnosis;Diagnostic;diagnostic accuracy;Differential Diagnosis;Dimensions;Economic Burden;Eligibility Determination;Evaluation;Excision;Exhibits;Fatty acid glycerol esters;Financial Hardship;Fingerprint;follow-up;Goals;Graph;Health Care Costs;Healthcare Systems;healthy volunteer;Heterogeneity;Histologic;Histology;human old age (65+);Image;Image Analysis;imaging biomarker;imaging capabilities;Imaging Techniques;improved;Kidney;Kidney Diseases;kidney imaging;lipid metabolism;Lipids;Machine Learning;machine learning method;Magnetic Resonance;Magnetic Resonance Imaging;Malignant - descriptor;Malignant neoplasm of kidney;Malignant Neoplasms;Maps;Measurement;Measures;Medicare;Methodology;Methods;Morbidity - disease rate;Morphologic artifacts;mortality;Motion;Neoplasm Metastasis;Normal Range;novel;older patient;Operative Surgical Procedures;overtreatment;Oxyphilic Adenoma;Papillary;Patient Selection;Patients;Positioning Attribute;predictive modeling;Predisposition;Procedures;Property;prospective;Psychosocial Stress;Publications;quantitative imaging;Relaxation;Renal Carcinoma;Renal Cell Carcinoma;Renal Mass;Reporting;Reproducibility;Resolution;Risk;Sampling;Sensitivity and Specificity;Slice;Societies;soft tissue;spatiotemporal;Standardization;Techniques;Technology;Three-Dimensional Imaging;Time;tissue mapping;Tissues;tool;treatment strategy;tumor;Unnecessary Surgery;Up-Regulation;Validation

PROJECT_TITLE: Development of Magnetic Resonance Fingerprinting in Kidney for Evaluation of Renal Cell Carcinoma

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology

ORG_CITY: BALTIMORE

ORG_DEPT: PHYSIOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE This research project will use the large number of protein sequences that have become available in the last few decades to learn the rules that give proteins their unique properties. These rules will emphasize covariance, an important feature in which the sequence in one region of a protein influences the sequence in another region, much like the rhyming words in separate lines of a poem or song. With these rules may help understand how proteins function in health and disease, and may one day help to design proteins that can be used as drugs or medical diagnostic.

PI_NAMEs: BARRICK, DOUGLAS E. (contact)

PROGRAM_OFFICER_NAME: NGUYEN, HAN

PROJECT_TERMS: Adopted;Affect;Affinity;Amino Acid Sequence;Binding;Biological;Catalysis;clinical diagnostics;Communication;Consensus;Consensus Sequence;Coupling;Data;deep learning;design;Disease;DNA Binding;Elements;enzyme activity;Enzymes;Exclusion;falls;Family;Frequencies;Funding;globular protein;Health;insight;Learning;Linear Algebra;Mainstreaming;Measures;Methods;Modeling;Molecular Biology;Mutagenesis;Mutation;novel;novel strategies;Pathway interactions;Pattern;Pharmaceutical Preparations;Phylogenetic Analysis;Positioning Attribute;predictive tools;Property;Protein Binding Domain;Protein Engineering;Protein Family;protein folding;protein function;protein structure prediction;Proteins;rapid growth;Research;Research Project Grants;Role;Sampling;Sequence Alignment;Sequence Determination;Site;Site-Directed Mutagenesis;Source;Specificity;statistics;Structure;success;Taxonomy;Testing;Thermodynamics;Time;tool;Variant;vector

PROJECT_TITLE: Consensus and Covariance Proteins: Stability, Cooperativity, Function, & Design

STUDY_SECTION: MSFB

STUDY_SECTION_NAME: Macromolecular Structure and Function B Study Section[MSFB]


ADMINISTERING_IC: EB

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_CITY: LAWRENCE

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF KANSAS LAWRENCE

ORG_STATE: KS

PHR: Narrative The Biotechnology Resource Center of BioModular Multi-scale Systems (CBM2) for Precision Medicine will generate technologies to enable precision decisions on managing different disease states. The technologies evolving from the Center will possess unique and compelling operating characteristics that will provide diagnostic and prognostic information obtained from liquid biopsy markers. The technologies will use amplification-free single-molecule processing in a highly multiplexed format that will provide disease-specific signatures to help guide physicians on making critical clinical decisions (i.e., Precision Medicine) to improve patient outcomes.

PI_NAMEs: SOPER, STEVEN ALLAN (contact)

PROGRAM_OFFICER_NAME: MULVANEY, SHAWN PATRICK


PHR: Narrative The Biotechnology Resource Center of BioModular Multi-scale Systems for Precision Medicine is seeking to evolve its mission, which is to design, model, fabricate, test and translate into the biomedical community innovative tools to enable precision medicine across different disease states using liquid biopsy markers. The lofty vision for the Center will be realized through a stable and engaging Administrative Core that will facilitate the timely delivery and dissemination of innovative tools into the research and clinical communities.

PROJECT_TERMS: Adopted;Advisory Committees;Affect;Annual Reports;Biological;Biological Assay;Biotechnology;cell free DNA;Cells;Circulation;Clinical;Collaborations;Commercial Sectors;Committee Members;Communities;Complex;Data;design;Development;Devices;Disease;DNA;Educational workshop;Epigenetic Process;Evolution;experience;extracellular vesicles;fabrication;Flow Cytometry;Future;Generations;Goals;Grant;Human Resources;Infrastructure;Injections;innovation;Institution;instructor;instrumentation;Interdisciplinary Study;interest;Leadership;Length;liquid biopsy;manufacture;meetings;member;Microscopy;Mission;Modeling;Modification;Molds;Molecular;Molecular Analysis;Molecular Biology;multidisciplinary;Nanotechnology;National Institute of Biomedical Imaging and Bioengineering;Nature;nature center;new technology;organizational structure;Outcome;Output;Participant;Plastics;precision medicine;Private Sector;Privatization;Procedures;Process;program dissemination;programs;prospective;Proteins;Records;recruit;Reporting;Research;Research Personnel;Resolution;Resources;response;RNA;Running;Schedule;Scholars Program;Seasons;Secure;Services;single molecule;Site;skills;success;Surface;Surveys;System;Talents;Technology;technology platform;Testing;tool;Training;Training Programs;Translating;United States National Institutes of Health;Update;Vision;visiting scholar;web site;Work

PROJECT_TITLE: Facilitating a Multi-Institutional Enterprise


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Cancer;Clinical Research;Colorectal Cancer;Digestive Diseases;Genetics;Immunotherapy;Orphan Drug;Radiation Oncology;Rare Diseases

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

ORG_STATE: NY

PHR: PROJECT NARRATIVE Ionizing radiation is known to induce cellular senescence and activate a secretory program that can result in immune modulation. We have shown that senescence is a significant contributor to the anti-tumor response to ionizing radiation. We propose to use mouse and human models of rectal cancer to define the contribution of senescence and its secretory program to the antitumor effects of radiation, to characterize how radiation-induced senescence remodels the tumor immune environment, and to assess the contribution of radiation-induced senescence and its secretory program to render systemic anti-tumor responses that can be augmented with immune checkpoint blockade.

PI_NAMEs: ROMESSER, PAUL BERNARD (contact)

PROGRAM_OFFICER_NAME: BIAN, YANSONG

PROJECT_TERMS: Abscopal effect;Advisory Committees;anti-cancer research;anti-PD-1;anti-PD1 therapy;Antibodies;antitumor effect;Antitumor Response;bench to bedside;biobank;Biology;Cancer Biology;Cancer Model;Cancer Patient;cancer therapy;career;career development;Cell Aging;Cell Cycle Arrest;cell type;Cells;chemokine;chemoradiation;Clinical;clinical training;clinical translation;clinically relevant;Contralateral;cytokine;Data;defined contribution;Dependence;Development Plans;Distant;DNA Damage;Educational workshop;Effector Cell;Environment;Epithelium;experience;Flow Cytometry;Foundations;Funding;Future;Genetic;Genetically Engineered Mouse;Genotype;Goals;Growth;Human;human model;Immune;immune activation;immune cell infiltrate;immune checkpoint blockade;Immunity;Immunocompetent;Immunologic Stimulation;Immunophenotyping;immunoregulation;Immunotherapy;in situ imaging;Inflammatory;Infrastructure;Interdisciplinary Study;International;Ionizing radiation;Irradiated tumor;irradiation;Laboratories;Malignant Neoplasms;Mediating;Mediator;Memorial Sloan-Kettering Cancer Center;Mentors;Messenger RNA;Modality;Modeling;mouse model;Multiplexed Ion Beam Imaging;Mus;neoplastic cell;novel;novel strategies;novel therapeutics;Organoids;Pathway interactions;Patients;Physicians;Positioning Attribute;programs;Proteins;Radiation;radiation effect;Radiation Oncologist;Radiation Oncology;Radiation therapy;Radiation Tolerance;Radiobiology;randomized, clinical trials;rational design;Rectal Cancer;Research;Research Personnel;Research Project Grants;response;Role;Sampling;Scientist;senescence;senescence associated secretory phenotype;single-cell RNA sequencing;Testing;Therapeutic;Tissues;TP53 gene;Training;transcriptome sequencing;treatment response;tumor;tumor microenvironment;Tumor-Derived;tumor-immune system interactions;Up-Regulation;Visualization;Work

PROJECT_TITLE: Investigating the contribution of cellular senescence to the efficacy of radiation therapy.

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Adolescent Sexual Activity;Behavioral and Social Science;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Infectious Diseases;Mental Health;Pediatric;Pediatric - AIDS;Prevention;Social Determinants of Health

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

PHR: PROJECT NARRATIVE The proposed study will evaluate the impact of Family Connections, a family-based group intervention for adolescents and young adults (AYA) living with HIV and their family caregivers. The intervention seeks to increase social and family support and decrease self-stigma among AYA, so they may improve their medication adherence and achieve an undetectable viral load. Findings will fill a critical gap in available evidence-based intervention options for improving the HIV-related outcomes and wellbeing of HIV-positive AYA in sub-Saharan Africa.

PI_NAMEs: DENISON, JULIE ANNE (contact)

PROGRAM_OFFICER_NAME: KAMATH, SUSANNAH M A

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;Adolescent;Adolescent and Young Adult;Adult;Africa South of the Sahara;Age;AIDS prevention;antiretroviral therapy;arm;Behavior;Caregiver Burden;caregiver interventions;Caregivers;Caring;Cause of Death;Cessation of life;Chronic Disease;Clinic;cognitive function;Communication;comparison group;Data;Data Collection;design;Development;Disparate;Disparity;emotion regulation;Enrollment;Ensure;Event;Evidence based intervention;executive function;Failure;Family;Family Caregiver;family support;Feeling;Future;group intervention;Group Meetings;Health;HIV;HIV diagnosis;HIV Seropositivity;HIV-infected adolescents;improved;Individual;innovation;internalized stigma;Intervention;Learning Skill;Life;Measures;Medical;medication compliance;Monitor;mortality;Outcome;Participant;Pediatric Hospitals;peer;Personal Satisfaction;Persons;Pilot Projects;pilot test;Play;Population;positive youth development;Prevention;programs;Province;Randomized;Randomized, Controlled Trials;Recommendation;Research;Research Design;response;Role;Self Management;sexual and reproductive health;Shame;Signal Transduction;skills;social cognitive theory;social stigma;Social support;statistics;Stress;success;System;Testing;therapy adherence;therapy design;Training;treatment arm;treatment program;United States National Institutes of Health;Viral;Viral Load result;Work;Youth;Zambia

PROJECT_TITLE: Family Connections cluster RCT in Zambia: Impact of a youth and caregiver intervention on virologic status among HIV-positive youth (ages 15-21)

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Genetics;Nanotechnology;Ovarian Cancer;Precision Medicine;Rare Diseases;Women's Health Research

PHR: Narrative As the Precision Medicine Initiative seeks to improve patient care by securing detailed molecular information on a patient’s disease, new diagnostic/prognostic markers and the tools to analyze them become increasingly needed. These needs include the ability to analyze low abundance markers (i.e., liquid biopsy markers) with a simple workflow required for clinical implementation. In TR&D 1, the Center will develop innovative tools for the processing of rare liquid biopsy markers’ molecular cargo at the single-molecule level without the need for amplification. Specifically, the tools consist of solid-phase enzymatic reactors coupled to nanoscale electrophoresis to allow for real time readout of the products generated from an enzymatic reaction.

PROJECT_TERMS: Affinity;Antibodies;Beds;Biochemical Reaction;Biology;Bioreactors;Biotechnology;Biotin;Blood capillaries;CA-125 Antigen;Cell Line;Charge;Chemistry;Chromatography;Clinic;clinical implementation;Clinical Markers;copolymer;Copy Number Polymorphism;Coupled;Cycloparaffins;Cytolysis;density;Detection;Development;Diagnostic;Digestion;digital;Dimensions;Disease;Disease Management;DNA;DNA amplification;Dose;Electrophoresis;Engineering;enzyme activity;Enzymes;Epigenetic Process;Exonuclease;Exoribonucleases;experience;Extracellular Domain;extracellular vesicles;Fluorescence;Genomic DNA;Goals;Harvest;Immobilization;Immobilized Enzymes;improved;Injections;innovation;Kinetics;Label;Light;liquid biopsy;Malignant neoplasm of ovary;Maps;Masks;Measures;Medicine;Membrane Proteins;Microfluidic Microchips;Modality;Modification;Molds;Molecular;molecular marker;Molecular Profiling;Monitor;N-hydroxysulfosuccimide;nanocolumn;nanofluidic;nanoimprint lithography;nanolitre;nanometer;nanopore;nanoscale;Neoplasm Circulating Cells;next generation sequencing;novel;novel diagnostics;Output;Ovarian Carcinoma;Ozone;Patient Care;Patients;Peptide Hydrolases;Peptide Mapping;Peptides;Phase;Plastics;Polymethyl Methacrylate;precision medicine;Precision Medicine Initiative;Process;prognostic;Prognostic Marker;prognostic value;Protein Fingerprints;Proteins;Reaction;Reaction Time;Reporting;Resources;Ribonucleotides;RNA;Running;Sampling;Secure;sensor;single molecule;Single-Stranded DNA;Solid;Streptavidin;submicron;success;Surface;System;Techniques;Technology;Time;tool;Trypsin;Tube;two-dimensional

PROJECT_TITLE: Single-Molecule Processing: Detection and Identification of Single DNAs, RNAs, and Proteins using Immobilized Nanoscale Enzymatic Reactors (INERs) and Nanoscale Electrophoresis


ADMINISTERING_IC: TR

ED_INST_TYPE: OVERALL MEDICAL

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Clinical Research

ORG_CITY: PORTLAND

ORG_DEPT: MISCELLANEOUS

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PI_NAMEs: FRYER, ALLISON DEBORAH (contact);MCGREGOR, JESSINA C;WILSON, ANNA CAMILLE

PROGRAM_OFFICER_NAME: RADMAN, THOMAS C

PROJECT_TERMS: Basic Science;career;career development;Clinical Competence;Clinical Research;Clinical Sciences;Communication;Competence;Complex;data management;Degree requirements;Development;Discipline;Doctor of Pharmacy;Doctor of Philosophy;doctoral student;Enrollment;experience;graduate student;Individual;inter-institutional;Journals;Leadership;Medical Students;Mentors;Mentorship;Methods;National Research Service Awards;Oregon;Postdoctoral Fellow;pre-doctoral;professional students;Program Description;programs;Research;Research Project Grants;Science;Scientist;skills;Students;TNFSF15 gene;Training;Training Programs;Translational Research;Translations;Universities;Writing

PROJECT_TITLE: NRSA Training Core


ORG_DEPT: PATHOLOGY

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: PROJECT NARRATIVE The tumor microenvironment is a critical driver of cancer progression in colorectal cancer (CRC). Dr. Duran’s application to the R50 Research Specialist Award will support Dr. Moscat’s research program focused on the role of the tumor microenvironment in CRC. Unveiling the mechanisms that control this crosstalk is crucial to find new therapeutic targets for CRC.

PI_NAMEs: DURAN MOLINA, MARIA ANGELES  (contact)

PROGRAM_OFFICER_NAME: LUO, RUIBAI

PROJECT_TERMS: Area;Award;Bioinformatics;bioinformatics tool;Biology;Cancer Biology;cancer type;Cells;Colorectal Cancer;Complex;Dedications;design;Desmoplastic;effective therapy;Funding;Grant;human disease;in vivo;in vivo Model;Inflammation;Inflammatory;Knowledge;Laboratories;Malignant Neoplasms;Medicine;Mesenchymal;Metabolic;Metabolism;Modeling;Molecular;mouse model;new therapeutic target;novel;Pathology;Process;Prognosis;programs;Research;Role;Scientist;Seminal;Signal Transduction;Specialist;success;Technical Expertise;Time;Training;tumor microenvironment;tumor progression;Wages

PROJECT_TITLE: Dissecting the in vivo stromal metabolic and inflammatory crosstalk in colorectal cancer


ORG_CITY: BOSTON

ORG_NAME: DANA-FARBER CANCER INST

ORG_STATE: MA

PHR: PROJECT NARRATIVE Chronic myelomonocytic leukemia (CMML) is a highly aggressive blood cancer with no effective drug therapies. Mutations in the CBL gene, which occur in approximately 15% of CMML patients, are associated with an especially poor prognosis. This project will employ cutting-edge genetic and pharmacologic approaches to identify new targeted therapies for patients with CBL-mutant CMML.

PI_NAMEs: BELIZAIRE, ROGER VINCENT (contact)

PROGRAM_OFFICER_NAME: WALLACE, TIFFANY A

PROJECT_TERMS: acquired drug resistance;Adaptor Signaling Protein;Advisory Committees;Alleles;Binding;Biological;Biology;Bone Marrow;career;career development;CBL gene;CBL Protein;Cell Line;Cell Proliferation;Cell Survival;Cells;Chronic Myelomonocytic Leukemia;Clinical;clinical practice;clinical translation;Collaborations;Combined Modality Therapy;Communities;CRISPR screen;CRISPR/Cas technology;Dana-Farber Cancer Institute;Dasatinib;Data;design;Development;Development Plans;Disease;Disease Resistance;Drug resistance;drug resistance development;Educational process of instructing;effective therapy;efficacy testing;Environment;experimental study;FDA approved;FRAP1 gene;Genetic;genome-wide;Hematologic Neoplasms;Hematopoietic;Hematopoietic Neoplasms;improved;In Vitro;in vivo;Individual;inhibitor;innovation;Knock-out;Laboratories;loss of function;LYN gene;Malignant Neoplasms;Measures;Mediating;Mentors;Mentorship;mouse model;Mus;mutant;Mutate;Mutation;Myelogenous;myeloid leukemia cell;Neoplasms;new therapeutic target;novel therapeutics;Oncogenic;overexpression;Pathologist;Pathology;Pathway interactions;patient derived xenograft model;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;pharmacologic;Pharmacotherapy;Phenotype;Phosphotransferases;Physicians;PI3K/AKT;prevent;Principal Investigator;Prognosis;Proliferating;Regimen;Research;Research Personnel;Research Proposals;Resistance;resistance mechanism;Role;Sampling;Scientist;Selection for Treatments;Series;Signal Transduction;src-Family Kinases;SYK gene;Therapeutic;Time;Training;transfusion medicine;translational potential;Translational Research;Treatment Efficacy;Tyrosine Kinase Inhibitor;ubiquitin-protein ligase;Work;Writing

PROJECT_TITLE: Novel targeted therapies for chronic myelomonocytic leukemia


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics;Machine Learning and Artificial Intelligence;Nanotechnology;Precision Medicine

PHR: Narrative The Biotechnology Resource Center of BioModular Multi-scale Systems (CBM2) for Precision Medicine will produce an innovative label-free nanofluidic sensor with in-plane nanopores for not only detecting unamplified single molecules, but also identifying them via their molecular-dependent time-of-flight (TOF). The hardware and software required for high throughput label-free TOF sensing will be developed. By integrating solid-phase nanoscale reactors with the in-plane nanopores and nano-columns, this sensor can be configured to provide molecular information from unamplified targets (DNA, RNA, and proteins) with unprecedented identification accuracies (>95%).

PI_NAMEs: PARK, SUNGGOOK  (contact)

PROJECT_TITLE: An innovative label-free dual-nanopore TOF sensor for detection and identification of single molecules


ED_INST_TYPE: HOSPITALS

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative  Hybrid insulin peptides (HIPs) form through peptide bond formation between proinsulin fragments and other beta-cell peptides. These neoepitopes contain non-genomic amino acid sequences, making them plausible targets for disease-driving T cells in Type 1 Diabetes (T1D). Here, we propose to (1) Modulate autophagy in human islets to maximize HIP-content for mass spectrometric identification; (2) Study the role of metabolic stress on HIP-accumulation in NOD islets; (3) Analyze biochemical mechanism of HIP formation in human islets; (4) Study the role of novel HIPs in T1D pathogenesis through ELISPOT analyses; (5) Develop and implement a bioinformatics algorithm for the mass spectrometric identification of native and hybrid peptides.

PI_NAMEs: DELONG, THOMAS  (contact)

PROGRAM_OFFICER_NAME: WANG, XUJING

PROJECT_TERMS: aged;Algorithms;Amino Acid Sequence;Animal Model;Antigens;Artificial Intelligence;Autoantigens;Autoimmune;Automobile Driving;Autophagocytosis;autoreactive T cell;autoreactivity;Bayesian Analysis;Benchmarking;Beta Cell;Biochemical;Bioinformatics;Biological Markers;Blinded;Cathepsins;CD4 Positive T Lymphocytes;Cells;Cellular Structures;Clone Cells;Communities;Computational algorithm;Computers;cytokine;Data;Data Set;Databases;Defect;Degradation Pathway;Detection;Diabetes Mellitus;diabetes pathogenesis;diabetic;Disease;enzyme linked immunospot assay;Epitopes;Expert Systems;exposed human population;Family;Fever;Funding;Generations;Grant;granule cell;High temperature of physical object;Homeostasis;Human;Hybrids;improved;Inbred NOD Mice;Individual;induced pluripotent stem cell;innovation;instrument;Insulin;insulin dependent diabetes mellitus onset;insulin granule;Insulin-Dependent Diabetes Mellitus;interest;islet;Islets of Langerhans;Lead;Ligation;Lysosomal Function Inhibition;Marketing;mass spectrometer;Mass Spectrum Analysis;Mediating;Metabolic stress;Methodology;Mus;neoantigens;new technology;new therapeutic target;Non obese;non-diabetic;non-genomic;novel;Organ Donor;Pathogenesis;Pathogenicity;Patients;Peptide Hydrolases;Peptides;peripheral blood;Peripheral Blood Mononuclear Cell;Play;Post-Translational Protein Processing;predictive modeling;Prevention;Proinsulin;Proteomics;Reagent;Research;Research Design;Residual state;Role;Sampling;Specificity;Stress;Subgroup;success;T-Cell Receptor;T-Lymphocyte;T-Lymphocyte Epitopes;Techniques;Technology;Testing;therapeutic target;tool;United States National Institutes of Health

PROJECT_TITLE: Characterize the Landscape and Origin of Hybrid Peptides in Beta Cells

STUDY_SECTION: BMDM

STUDY_SECTION_NAME: Basic Mechanisms of Diabetes and Metabolism Study Section[BMDM]


NIH_SPENDING_CATS: Anorexia;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Eating Disorders;Mental Health;Mental Illness;Neurosciences;Nutrition;Pediatric;Precision Medicine;Serious Mental Illness

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE Anorexia nervosa (AN) is a deadly psychiatric disorder associated with marked medical and psychosocial impairment and chronic course. The current study will use neurocognitive tasks and computational modeling to test the possibility that deficits in reinforcement learning account for response to the first line treatment for adolescent AN, Family-Based Treatment (FBT). By better characterizing neurocognitive predictors of response to FBT, findings from this investigation will facilitate the identification of participants at greater risk for treatment failure and ultimately inform the development of adjunctive treatments to improve outcome.

PI_NAMEs: REILLY, ERIN E. (contact)

PROGRAM_OFFICER_NAME: BECHTHOLT, ANITA JEAN

PROJECT_TERMS: Adolescence;Adolescent;Adolescent Development;Adult;Anorexia Nervosa;Anxiety;behavior change;Behavior Therapy;Behavioral;behavioral response;Biometry;Body Weight;career;Child;Chronic;Clinical;Clinical Research;cognitive neuroscience;Cognitive Science;Computer Models;Computing Methodologies;cost;Data;Development;Disease;Disease remission;Eating;Eating Behavior;Eating Disorders;economic cost;Effectiveness;evidence base;Evidence based treatment;experience;Exposure to;Family;Feedback;feeding;follow-up;Food;Formulation;Fright;Goals;Hyperphagia;Impairment;improved;improved outcome;indexing;Individual;insight;Intervention;Intervention Studies;Interview;Investigation;K-Series Research Career Programs;Learning;learning outcome;Link;Medical;medical complication;Mental Depression;Mental disorders;Mentorship;Methods;neural;Neurobehavioral Manifestations;Neurobiology;Neurocognition;Neurocognitive;Obsessive compulsive behavior;Outcome;Parents;Participant;patient oriented;Performance;predicting response;prevent;Process;Psychiatry;psychologic;Psychological reinforcement;Psychopathology;psychosocial;Punishment;Research;research based treatment;Research Personnel;response;Rewards;Risk;Sampling;Selection for Treatments;Shapes;skill acquisition;skills;Stimulus;success;Symptoms;Testing;Theoretical model;therapy development;Training;Treatment Failure;Treatment outcome;treatment response;treatment risk;United States;Weight;Weight Gain;Work;Youth

PROJECT_TITLE: Using Computational Modeling to Test Reinforcement Learning as a Predictor of Response in Family-Based Treatment for Adolescent Anorexia Nervosa


PHR: Narrative The Biotechnology Resource Center of BioModular Multi-scale Systems (CBM2) for Precision Medicine will develop technologies to enable robust manufacturing and assembly of modular, integrated platforms to provide clinicians and researchers with more detailed information about patient health to facilitate disease management. The assembly technology will permit seamless transfer of rare liquid biopsy markers from module-to- motherboard for blood-to-sequencing enabling more reliable operation. The power and versatility of the technology will be demonstrated by sequencing circulating tumor cells extracted from blood and provide an electrical readout of diagnostic mutations they may carry.

PI_NAMEs: MURPHY, MICHAEL C. (contact)

PROJECT_TERMS: Adopted;Bacterial Infections;Biological;Biological Assay;Biological Markers;Biopsy Specimen;Biotechnology;Blood;Blood capillaries;Blood specimen;Cell Extracts;Cells;ChIP-seq;Clinical;clinical application;Complex;cost;design;Development;Diagnostic;Disease Management;DNA;Drug resistance;elastomeric;Elastomers;Electronics;Elements;Ensure;Exonuclease;experience;Failure;Film;Genes;Genome;Geometry;Goals;Health;Heating;high standard;high volume manufacturing;improved;Injections;innovation;instrument;knowledge base;large scale production;Length;liquid biopsy;Liquid substance;Malignant Neoplasms;manufacture;manufacturing process;manufacturing technology;Membrane;Metals;meter;Microfluidic Microchips;Microfluidics;Molds;Molecular;Molecular Analysis;Mutation;nanofluidic;nanosensors;Neoplasm Circulating Cells;novel;operation;Partner in relationship;Patients;Plasma;Play;Polymers;Positioning Attribute;precision medicine;Preparation;pressure;Procedures;Process;Production;Proteins;rapid technique;Reaction;Reagent;Reporting;research clinical testing;Research Personnel;Resources;RNA;Sampling;seal;Side;single molecule;Standardization;Stress;Stroke;Structure;success;Surface;System;Systems Integration;Technology;Time;tool;virtual

PROJECT_TITLE: Manufacture and Assembly of Thermoplastic, Modular, Integrated Fluidic Systems


PHR: PROJECT NARRATIVE  Cardiometabolic risks are a major health challenge facing the overweight and obese US population. The adipose tissue of overweight/obese individuals lacks adequate oxygenation, which instigates local and systemic low-grade inflammation.  We have identified a novel adipokine, interleukin 19, that is able to modulate angiogenesis and inflammation in visceral fat depots. IL-19 can preserve microvascular function of adipose tissue thus reducing cardiometabolic risks and cardiovascular disease.  This research will improve our understanding of the mechanisms that govern adipose tissue dysfunction in obesity, and it will provide a framework for developing new therapeutic strategies to avert cardiometabolic disorders in the overweigh/obese population of the USA.

PI_NAMEs: AUTIERI, MICHAEL V;SCALIA, ROSARIO G (contact)

PROGRAM_OFFICER_NAME: BASU, RAJATAVA

PROJECT_TERMS: Ablation;Acute Disease;Adhesions;Adhesives;Adipocytes;adipokines;Adipose tissue;angiogenesis;Angiogenesis Pathway;Ants;Atherosclerosis;Attenuated;Biochemical;Blood flow;Blood Glucose;Blood Vessels;Cardiometabolic Disease;cardiometabolic risk;cardiometabolism;Cardiovascular Diseases;Cell Adhesion Molecules;Cells;Central obesity;Chronic Disease;cytokine;Data;density;Development;diet-induced obesity;Disease;Disease Resistance;Dyslipidemias;Endothelial Cells;Endothelium;Epidemic;experience;Fasting;Fatty acid glycerol esters;feeding;Fibrosis;Flow Cytometry;Functional disorder;Gene Expression;Genetic;Goals;Health;Heart Diseases;Homeostasis;human tissue;Hypertension;Hypoxia;immune cell infiltrate;Impairment;improved;Incidence;Inflammation;Inflammatory;Inflammatory Infiltrate;Inflammatory Response;Insulin Resistance;insulin sensitivity;insulin signaling;interleukin-19;Interleukins;intravital microscopy;Kidney Diseases;knock-down;Knock-out;Laboratories;Leucocytic infiltrate;Leukocytes;Lymphocyte;Macrophage;Metabolic Diseases;Microcirculation;Modeling;Molecular;monocyte;Morphology;mouse model;Mus;neutrophil;new therapeutic target;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutic intervention;obese person;Obesity;Organ;Organism;overexpression;Overweight;Pathway interactions;Peripheral;Persons;Phenotype;Physiological;Population;preservation;prevent;Publishing;Regulation;Reperfusion Injury;Research;Research Personnel;response;Risk;Risk Factors;Role;subcutaneous;Techniques;Technology;Testing;Therapeutic;trafficking;Transgenic Mice;Vascular Endothelium;Vascularization;Visceral;Visceral fat;Weight Gain;Work

PROJECT_TITLE: Regulation of adipose tissue microvascular function by IL19

STUDY_SECTION: IVPP

STUDY_SECTION_NAME: Integrative Vascular Physiology and Pathology Study Section[IVPP]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Precision Medicine

ORG_CITY: GRAND RAPIDS

ORG_NAME: VAN ANDEL RESEARCH INSTITUTE

PHR: PROJECT NARRATIVE Cancer arises from the loss of control of growth in cells. Although attention has focused mostly on genetic mutations as the origin of these defects, it has become clear that changes in the epigenetic control of gene activity also contribute to this loss of growth control. This project aims to provide epigenetic analysis of clinical trial epigenomic data to advance our understanding of how epigenetic defects impact cancer biology and clinical outcome.

PI_NAMEs: LAIRD, PETER W (contact);SHEN, HUI

PROGRAM_OFFICER_NAME: YANG, LIMING

PROJECT_TERMS: Age;ATAC-seq;Attention;Base Sequence;Binding Sites;bioinformatics tool;Biological Assay;bisulfite;bisulfite sequencing;Cancer Biology;cancer cell;Cancer Center;cancer classification;Cancer Detection;cancer genome;cancer genomics;Cancer Model;cancer recurrence;cancer subtypes;Categories;Cells;Chemoresistance;ChIP-seq;Chromatin;chromatin remodeling;Clinical;Clinical Data;clinical trial analysis;Clinical Trials;clinically relevant;Cluster Analysis;Code;Competence;Complement;Custom;Cytosine;Data;Data Analyses;data harmonization;Defect;determinants of treatment resistance;Development;DNA;DNA Integration;DNA Methylation;DNA Modification Process;DNA Sequence Alteration;driver mutation;Enhancers;Epigenetic Process;epigenetic silencing;epigenomic profiling;epigenomics;Event;Evolution;exceptional responders;Formalin;Functional disorder;Gastrointestinal Neoplasms;gene repair;Genes;genetic information;Genome;Genome Data Analysis Network;Genomics;Growth;Higher Order Chromatin Structure;histone methylation;histone modification;Human;Hypermethylation;innovation;insight;interest;Malignant neoplasm of gastrointestinal tract;Malignant Neoplasms;Methylation;Microsatellite Instability;Mismatch Repair;Mitosis;MLH1 gene;Molecular;molecular pathology;mouse model;multiple data types;Mutation;Nature;novel;Oncogene Activation;Outcome;Paraffin Embedding;Pathway Analysis;Play;Prevalence;Productivity;programs;promoter;Proteins;Proteomics;Quality Control;Race;Reader;Role;sample fixation;Sampling;sex;Somatic Mutation;Specimen;temporal measurement;tool;transcription factor;transcriptome sequencing;transcriptomics;tumor;Tumor Suppressor Genes;Validation;Variant

PROJECT_TITLE: Integrative Cancer Epigenomic Data Analysis Center (ICE-DAC)


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Services;Mental Health;Pediatric

ORG_CITY: WASHINGTON

ORG_NAME: CHILDREN'S RESEARCH INSTITUTE

ORG_STATE: DC

PHR: PROJECT NARRATIVE “Science Journeys” is a unique educational experience for children and families who are navigating hospitalization and complex medical care, an often high-stress experience and one that leads students to miss prolonged periods of in school time. With the aid of multimedia tools, “Journeys” participants will use their own health data to further their understanding of the body, what diseases affect kids, and how diagnostic methods/tests, treatments, and healthcare teams help them get well. Ultimately, this hands-on engaging STEM focused program will support the physical and mental wellness of those seeking care and increase agency in their health journey. .

PI_NAMEs: LUBAN, NAOMI L (contact)

PROGRAM_OFFICER_NAME: FAUPEL-BADGER, JESSICA

PROJECT_TERMS: Active Learning;Advanced Practice Nurse;Advocate;Affect;Age;Ambulatory Care;Area;Biological Models;Body System;Broadcast Media;care seeking;career;Caregivers;Caring;Child;Child Development;Clinical Research;Clinical Trials;cognitive development;Collaborations;Complex;Curiosities;Data;Development;Diagnosis;Diagnostic Procedure;Disease;Drops;Education;Educational Curriculum;Educational workshop;Effectiveness;Emerging Technologies;Emotional;Engineering;Ensure;Evaluation;Event;evidence base;experience;Exposure to;Family;Funding;hands-on learning;Health;health data;Healthcare;Hospital Volunteers;Hospitalization;Hospitalized Child;Hospitals;Image;improved;informal learning;inpatient service;inquiry-based learning;Instruction;Learning;Libraries;Life;literacy;Mathematics;Medical;Medical Care Team;Medical Students;meetings;Mental Health;Modeling;Modification;Multimedia;New York;Next Generation Science Standards;novel;Nurses;Outpatients;Parents;Participant;Patients;Patients' Rooms;Pattern;Pediatric Hospitals;Persons;physical conditioning;Play;preservation;programs;Robotics;Schools;Science;Siblings;skills;social;Social Development;social emotional learning;Specialist;Stress;Students;symposium;Testing;Thinking;Time;tool;Training;virtual;Visit;volunteer;Well in self

PROJECT_TITLE: Science Journeys

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-H(55)R]


ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: Narrative: The diagnosis and treatment of diseases caused by dysregulation of lipid metabolism, including diabetes, cardiovascular disease, cancer, neurodegeneration, and fatty liver, is hinder by a lack of tools for measuring lipid biochemistry in vivo. Here, we develop tools for measuring the flux of lipids with stable isotopes using a novel ultra-high resolution mass spectrometer that can resolve natural abundance isotopes from tracer isotopes. We will overcome fundamental barriers to the implementation of this technology so that it can be accessed by the biomedical research community.

PI_NAMEs: MITSCHE, MATTHEW ALVIN (contact)

PROGRAM_OFFICER_NAME: BARNES, CHARLES ASHLEY

PROJECT_TERMS: Animal Model;Atherosclerosis;Biochemical Pathway;Biochemistry;Biomedical Research;Cardiovascular Diseases;Chromatography;Collaborations;Communities;Data;Data Collection;Deuterium;Development;Diabetes Mellitus;Diagnosis;Disease;effective therapy;effectiveness measure;Electrospray Ionization;Engineering;Environment;experience;Fatty acid glycerol esters;Fatty Liver;Goals;Human;human disease;implementation barriers;improved;in vivo;in vivo evaluation;Infusion procedures;instrument;Intervention;Ions;Isotope Labeling;Isotopes;Label;Lipid Biochemistry;lipid biosynthesis;lipid metabolism;lipidomics;Lipids;Location;Malignant Neoplasms;Manufacturer;Maps;mass spectrometer;Mass Spectrum Analysis;Measures;Metabolic;Metabolic syndrome;Modernization;mouse genetics;mouse model;multidisciplinary;Nerve Degeneration;Noise;novel;Patients;programs;Proteomics;Protocols documentation;Radioisotopes;Research;Resolution;Signal Transduction;Software Tools;Source;Specificity;stable isotope;Stable Isotope Labeling;Techniques;Technology;technology validation;Time;tool;Tracer;Training;Translating;ultra high resolution;Water

PROJECT_TITLE: Measuring Lipid Flux By Ultra High Resolution Mass Spectrometry

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-N(55)R]


PHR: Narrative The Training and Dissemination program will introduce the Center’s technologies to the biomedical and clinical communities and how they are being mobilized to enable Precision Medicine. The Center will demonstrate benefits associated with mixed-scale technologies in translational research. The Center will also implement strategies for building relationships between technologists, clinicians, and the general-public through networking, workshops, educational events, and a visiting scholar program.

PROJECT_TERMS: Affect;Area;base;bench to bedside;Biological;Biological Markers;Biological Process;biological systems;Biology;Biomedical Engineering;Biopsy Specimen;Biotechnology;Cell Size;Cells;Characteristics;Clinical;Clinical Research;Clinical Treatment;Collaborations;commercialization;Communities;Competence;Core Biopsy;Core Facility;design;Detection;Devices;Diagnosis;Diffusion;Disease;Disease Management;DNA;Education;Educational workshop;Entrepreneurship;Environment;Event;experience;experimental study;fabrication;Facebook;General Population;Generations;Healthcare;improved;in-vitro diagnostics;individualized medicine;industry partner;innovation;innovative technologies;Institution;Instruction;interest;International;Investigation;Label;Laboratories;lectures;Legal patent;Length;Link;liquid biopsy;Medical;meetings;member;meter;Microfluidics;MicroRNAs;Miniaturization;Mission;Modeling;Molecular;molecular marker;nanofabrication;nanofluidic;nanometer;nanoscale;Nanotechnology;new technology;news;Output;Participant;Patient Care;Patient-Focused Outcomes;Patients;Peer Review;Physicians;precision medicine;Process;program dissemination;Proteins;Publications;Reaction;Recruitment Activity;Research;Research Personnel;Resources;Role;Route;Sampling;Scholars Program;Secure;Series;Services;single molecule;Site;skills;social;social media;Source;stem;Students;System;Technology;technology research and development;tool;Training;Training Activity;Training Programs;Translating;Translational Research;Treatment Protocols;treatment strategy;Twitter;visiting scholar;web page;web site;webinar

PROJECT_TITLE: Sense-of-Scale: The use of mixed-scale systems for rare biomarker analysis


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: PROJECT NARRATIVE Optimizing antibiotic use is an immediate task to curtail antibiotic resistance and is an AHRQ research priority area. In order to safely optimize antibiotic use among newborn infants, an AHRQ priority population, accurate measurement of antibiotic use is required. The purpose of this pharmacoepidemiology study is to identify meaningful metrics of neonatal antibiotic use in order to allow hospitals and stakeholders to pinpoint antibiotic utilization practices that should be emulated or avoided, and ultimately improve the safety and quality of neonatal care.

PI_NAMEs: FLANNERY, DUSTIN DANIEL (contact)

PROGRAM_OFFICER_NAME: WILLIS, TAMARA

PROJECT_TITLE: Identifying Meaningful Metrics of Neonatal Antibiotic Use

STUDY_SECTION: HCRT

STUDY_SECTION_NAME: Healthcare Research Training [HCRT]


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Data Science;Genetics;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Psychosis;Schizophrenia;Serious Mental Illness

ORG_CITY: MANHASSET

ORG_NAME: FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH

PHR: Project Narrative The primary goal is to develop a psychosis biomarker that provides biologically relevant information in a quantitative, cost-effective, and scalable way. We will use state-of-the-art methods representing recent advances in computational linguistics to provide the first cross-diagnostic dimensional study of disorganized speech in psychosis, connecting computational features to key clinical characteristics with implications for illness trajectory.

PI_NAMEs: TANG, SUNNY XIAOJING (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: Address;analytical method;Area;behavioral phenotyping;Biological;Biological Markers;Biology;biomarker validation;Brain;Characteristics;Classification;Clinic;Clinical;clinical predictors;clinically relevant;Cognition;Cognitive;Complex;Computational Linguistics;Computer Models;Computing Methodologies;cost effective;Data Set;deep learning;deep learning model;Development;Diagnosis;Diagnostic;Dimensions;early onset;Ensure;Equity;experience;Failure;Foundations;Functional impairment;Future;Genetic Load;Genetic Risk;Goals;Impaired cognition;improved;Individual;individual variation;innovation;interest;Knowledge;Label;Lead;Learning;Linguistics;Machine Learning;machine learning method;machine learning model;Measurement;Measures;Mentorship;Methods;Modeling;Monitor;Mood Disorders;Outcome;Participant;Persons;Phenotype;Physicians;Population;Poverty;precision medicine;Psychiatric therapeutic procedure;Psychoses;psychotic;Relapse;Reproducibility;Research;Research Personnel;Resources;Sampling;schizophrenia spectrum disorder;Scientist;Severity of illness;Speech;Structure;symposium;Symptoms;synergism;Training;treatment response;Work

PROJECT_TITLE: Advancing Computational Linguistic Biomarkers of Disorganized Speech in Psychosis

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


ORG_CITY: HONOLULU

ORG_NAME: UNIVERSITY OF HAWAII AT MANOA

ORG_STATE: HI

PHR: The proposed Center for Pacific Innovations, Knowledge, and Opportunities (PIKO) addresses several issues of central importance to building a robust clinical and translational research (CTR) infrastructure that directly improves the health and wellbeing of indigenous Pacific People (IPP), defined as Native Hawaiians, Other Pacific Islanders, and Filipinos, and other underserved populations. The Center will establish a strong collaborative among three academic institutions and a statewide network of stakeholders, including practice-based and community-based organizations and health care providers; convert basic discoveries into real-world solutions to improve IPP health and reduce IPP health disparities; and increase the number of junior and other investigators, particularly from IPP backgrounds, for CTR careers.

PI_NAMEs: KAHOLOKULA, JOSEPH KEAWE'AIMOKU (contact);PALAFOX, NEAL A.

PROGRAM_OFFICER_NAME: FRINCU, CRINA

PROJECT_TERMS: Acceleration;Address;Adoption;Affect;Asian population;Biometry;Budgets;career;clinical development;Clinical Investigator;Clinical Research;Communication;Communities;community engagement;community organizations;Community Outreach;COVID-19 pandemic;culturally appropriate intervention;Data;Data Science;Death Rate;Development;disorder prevention;Dissemination and Implementation;Doctor of Philosophy;Economics;efficacy study;Ensure;Environment;Epidemiology;Ethnic Population;Evaluation;evidence base;Face;Filipino;Fostering;Funding;Hawaii;Hawaiian;Health;health care availability;health disparity;health disparity populations;Health Personnel;Health Promotion;Homelessness;Human;implementation strategy;improved;Indigenous;innovation;Institution;Institutionalization;Investments;Knowledge;Lead;Left;Life;marginalized community;medically underserved population;Mental Health;Mentors;Native Hawaiian or Other Pacific Islander;operation;Participant;Personal Satisfaction;Persons;physical conditioning;Pilot Projects;Policies;Population;Poverty;programs;racial population;Reduce health disparities;Registries;Research;Research Activity;Research Design;Research Infrastructure;Research Personnel;research study;Resources;Rural;rural area;Science;Sexual and Gender Minorities;social health determinants;socioeconomics;success;symposium;Translational Research;Trust;Underinsured;underserved community;Underserved Population;Unemployment;unhealthy lifestyle;Uninsured;United States;United States National Institutes of Health;Universities;user-friendly;Vulnerable Populations


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Pancreatic Cancer;Rare Diseases

ORG_CITY: LA JOLLA

ORG_NAME: SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

PHR: PROJECT NARRATIVE Pancreatic ductal adenocarcinoma (PDAC) is projected to be the second leading cause of cancer-related deaths in the United States and has been recognized as a recalcitrant cancer that requires accelerated research via the implementation of a long-term strategic plan. PDAC tumors have scarce nutrients, and to bypass this nutrient deficiency, cancer cells use an endocytic process called macropinocytosis as an amino acid supply route. We have identified that tumor support cells, called stromal cells, also use macropinocytosis for their survival and we propose to study how this uptake pathway works in these cells and whether it represents a vulnerability that can be targeted in PDAC therapy.

PI_NAMEs: COMMISSO, COSIMO  (contact)

PROGRAM_OFFICER_NAME: WOODHOUSE, ELIZABETH

PROJECT_TERMS: Ablation;Acceleration;Actins;Amino Acids;Automobile Driving;Bioenergetics;Biological;Bypass;cancer cell;Cancer Etiology;Cancer Patient;Cell Physiology;cell type;Cells;Cessation of life;chemotherapy;Cytoskeleton;Data;deprivation;Development;Evaluation;extracellular;Extracellular Protein;Fibroblasts;fitness;Glucose;Glutamine;Immune;Immune checkpoint inhibitor;In Vitro;in vivo;Link;Liquid substance;Malignant neoplasm of pancreas;Malignant Neoplasms;Metabolic;Metabolism;Modality;Molecular;mouse model;neoplastic cell;novel;novel therapeutics;Nutrient;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;pancreatic ductal adenocarcinoma model;Pathway interactions;Patients;pharmacologic;Phase;Phenotype;Play;Process;Property;Proteins;Publishing;Regulation;Research;Role;Route;sensor;Signal Transduction;Source;Starvation;Strategic Planning;Stress;Stromal Cells;Supporting Cell;Testing;Therapeutic;Time;tumor;tumor growth;tumor microenvironment;United States;uptake;Work

PROJECT_TITLE: Regulation and Function of Stromal Macropinocytosis in Pancreatic Ductal Adenocarcinoma

STUDY_SECTION: TME

STUDY_SECTION_NAME: Tumor Microenvironment Study Section[TME]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: KAHOLOKULA, JOSEPH KEAWE'AIMOKU (contact)

PROJECT_TERMS: Acceleration;adjudication;Administrator;Adopted;Advisory Committees;Award;Biomedical Research;Budgets;career development;Centers of Research Excellence;Clinical Research;Collaborations;Communication;Communities;community engagement;Conflict (Psychology);culturally appropriate intervention;Development;Disputes;dissemination strategy;Doctor of Philosophy;effectiveness evaluation;Eligibility Determination;Ensure;evidence base;experience;Filipino;flexibility;Fostering;Funding;Goals;Grant;Guidelines;Hawaii;Health;health disparity;health disparity populations;Health Promotion;improved;Indigenous;Information Technology;Infrastructure;innovation;Institution;inter-institutional;Knowledge;Leadership;meetings;Mentors;Minority-Serving Institution;Monitor;National Institute of General Medical Sciences;Native Hawaiian or Other Pacific Islander;Office of Administrative Management;operation;Outcome;Personal Satisfaction;Persons;Policies;Principal Investigator;Procedures;Process;Productivity;programs;Recommendation;Reduce health disparities;Research;Research Activity;Research Infrastructure;Research Personnel;Resolution;Resource Allocation;Resource Sharing;Resources;Science;senior faculty;Services;Specialist;Strategic Planning;Structure;success;Testing;timeline;Translational Research;Triage;Underrepresented Populations;Underserved Population;United States National Institutes of Health;Universities;Update

PROJECT_TITLE: Administrative Core


ADMINISTERING_IC: HD

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_CITY: CINCINNATI

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF CINCINNATI

PHR: Project Narrative Obstetric and pediatric patients often suffer from imprecise medical treatment due to vast interpatient variability and lack of individualized data amongst these populations. Electrochemical aptamer based sensors offer the potential for a generalizable approach to the on-demand, high- frequency monitoring of clinically relevant analytes, which could enable personalized treatment tailored to each individual patient. This proposal will usher in the first integrated EAB platforms deployable both in the clinic and in the home of the patient, serving as a catalyst for the clinical adoption of EAB sensors for a variety of applications in the treatment of disease in children, pregnant women, and beyond.

PI_NAMEs: WATKINS, ZACHARY L (contact)

PROGRAM_OFFICER_NAME: PILEGGI, ANTONELLO

PROJECT_TERMS: Adoption;Amino Acids;Animal Model;Animals;Antibiotics;aptamer;Area;Biological Markers;Biosensing Techniques;Biosensor;Blood;Blood Glucose;Calibration;Cardiac Surgery procedures;catalyst;Child;Childhood;Clinic;Clinical;clinical development;Clinical Trials;clinically relevant;Continuous Glucose Monitor;Cyclosporine;Data;design;Device or Instrument Development;Devices;Diabetes Mellitus;diabetic patient;Digoxin;Discipline of obstetrics;Disease;Doctor of Philosophy;Dose;Drug Monitoring;Electrodes;Enzymes;Fingers;Foundations;Frequencies;Glucose;glucose monitor;glucose sensor;Home;home test;Hormones;Hour;human subject;Hydrocortisone;improved;improved outcome;In Vitro;in vivo;Individual;individual patient;individualized medicine;innovation;Insulin;Intercellular Fluid;interpatient variability;LCN2 gene;lead candidate;Longevity;Medical;Membrane;Mentorship;Microfluidics;Modality;Modeling;Monitor;novel;nuclease;operation;Patient-Focused Outcomes;Patients;pediatric patients;Performance;personalized medicine;Pharmaceutical Preparations;Phenytoin;Physiological;point of care;point of care testing;Population;post gamma-globulins;Postoperative Period;precision medicine;Pregnancy;Pregnant Women;Progesterone;programs;Research;Risk;Sampling;sensor;Signal Transduction;success;Technology;test strip;Testing;Therapeutic;Therapeutic Index;Time;Translating;Troponin;Validation;Vancomycin;Variant;virtual;wearable device;Work

PROJECT_TITLE: Integrated Electrochemical Aptamer Based Platforms for the Point-of-Care and Continuous Monitoring of Clinically Relevant Analytes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F15-P(20)L]


ADMINISTERING_IC: AI

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: BERKELEY

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: PROJECT NARRATIVE Facultative pathogens like Vibrio cholerae must defend against the ubiquitous threat of predatory phages to cause disease in humans. This proposal aims to determine the molecular basis for the anti-phage activity of a group of mobile genetic elements in epidemic V. cholerae. Advances in our understanding of factors impacting microbial survival in states of disease will contribute to improved and targeted infection control measures.

PI_NAMEs: SEED, KIMBERLEY DIANE (contact)

PROGRAM_OFFICER_NAME: ZEITUNI, AMIR E

PROJECT_TERMS: Area;Bacterial Chromosomes;Bacteriophages;Biochemical;Biological Models;Capsid;Cells;Cholera;Chromosomes;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;Cryoelectron Microscopy;Data;Defense Mechanisms;Disease;Disease Outbreaks;Disease Outcome;DNA biosynthesis;driving force;Ecosystem;Electron Microscopy;Elements;Environment;Epidemic;Evolution;Excision;Gene Expression;gene product;Genes;Genetic;Genetic Materials;Genome;Genomics;global health;Goals;Human;improved;Infection;Infection Control;Infrastructure;inhibitor;Island;Life Cycle Stages;Lytic;Measures;Mediating;microbial;Mobile Genetic Elements;Modification;Molecular;Nature;novel;Open Reading Frames;Outcome;Parasites;pathogen;pathogenic bacteria;Predatory Behavior;Process;Production;Proteomics;Receptor Cell;Regulation;Resistance;response;Role;Sanitation;Small RNA;System;Tail;targeted nucleases;Techniques;Transcript;transmission process;Untranslated RNA;Vibrio cholerae;Virion;Water;waterborne pathogen;Work

PROJECT_TITLE: Phage resistance and mobile genetic elements in Vibrio cholerae

STUDY_SECTION: PCMB

STUDY_SECTION_NAME: Prokaryotic Cell and Molecular Biology Study Section[PCMB]


PI_NAMEs: BRAUN, KATHRYN LENZNER (contact)

PROJECT_TERMS: Agreement;Asian Americans;Biomedical Research;career;career development;Career Mobility;Centers of Research Excellence;Child;Childhood;Clinical;Clinical Investigator;Clinical Research;Clinical Trials Network;cohort;Collaborations;Communities;community building;community engagement;culturally appropriate intervention;Data;Data Analyses;design;Development;Development Plans;Discipline;Discrimination;Disparity population;Education;Educational Curriculum;Environment;Ethnic Origin;Expenditure;experience;Extramural Activities;Faculty;Feedback;Filipino;Fostering;Funding;Funding Agency;Geography;Goals;Grant;Hawaii;Health;health disparity;Homelessness;Imprisonment;improved;Indigenous;Individual;Infrastructure;innovation;Inosine Diphosphate;Institution;Knowledge;Leadership;Learning;Manuscripts;medical specialties;mentoring community;Mentors;minority health;minority health disparity;Minority-Serving Institution;Monitor;Native Hawaiian or Other Pacific Islander;Pacific Islander;Peer Review;personalized approach;Persons;Pilot Projects;Population;Principal Investigator;programs;Publishing;Race;Recording of previous events;recruit;Reduce health disparities;Reporting;Research;research data dissemination;Research Design;Research Infrastructure;Research Personnel;Research Support;Science;Secure;Services;Sexual and Gender Minorities;social health determinants;socioeconomic disparity;Source;Structure;Teacher Professional Development;Testing;Time Management;Training;Training and Infrastructure;Training Programs;Translational Research;translational research program;Trust;undergraduate student;underserved community;United States National Institutes of Health;Universities;uptake;Vulnerable Populations;Work;Writing

PROJECT_TITLE: Professional Development Core


ORG_CITY: CAMBRIDGE

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

PHR: U54 CENTER: NARRATIVE Metastatic organ colonization by circulating tumor cells depends on a response program in tumor cells, termed mechano-adaptation, to cope with mechanical and molecular stresses. In this U54 MetNet Center, we will integrate mechanical, genomic and ultrastructural information during metatastatic organ colonization and identify mechanical mechanisms of tumor cell fate decisions and identify pathways and potential therapeutic strategies to eliminate tumor cells prior to metastasis.

PI_NAMEs: KAMM, ROGER D (contact);SHENOY, VIVEK

PROGRAM_OFFICER_NAME: NADEAU, CHRISTINE FRANCES

PROJECT_TERMS: 3-Dimensional;Address;Adhesions;Adhesives;Affect;Basement membrane;Biological Assay;Blood Platelets;Breast Melanoma;cell behavior;Cell Communication;Cell Death;Cell Survival;cell type;Cells;Cessation of life;Chromatin;Chromatin Structure;Circulation;Complex;Computer Analysis;computer studies;coping;Cytoskeleton;Dermis;Disease;Disseminated Malignant Neoplasm;Endothelium;Environment;experience;experimental study;Extracellular Matrix;Extravasation;Fibrin;Gene Expression;Genomics;Goals;hemodynamics;Image;In Vitro;in vitro Model;in vivo;Individual;insight;Intervention;intravital imaging;Liver;Malignant Neoplasms;Measurement;Mechanics;metastatic process;Methods;Microcirculation;migration;Modeling;Molecular;monolayer;mortality;Neoplasm Circulating Cells;Neoplasm Metastasis;neoplastic cell;novel therapeutics;Nuclear;Organ;Organ Specificity;Pathway interactions;Phenotype;prevent;Primary Neoplasm;Probability;Process;programs;Proliferating;Property;Resolution;response;Role;shear stress;Site;Stress;stressor;Techniques;Technology;Therapeutic;Thrombus;Time;Tissues;transcriptome;transcriptomics;triple-negative invasive breast carcinoma;Tumor Cell Invasion;Vision;Work

PROJECT_TITLE: Mechanical determinants of organ-selective metastatic colonization, dormancy and outgrowth


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Hypertension;Networking and Information Technology R&D (NITRD);Nutrition;Prevention

ORG_CITY: ANN ARBOR

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: PROJECT NARRATIVE High dietary sodium intake is linked to incident hypertension (HTN) and cardiovascular events. Conversely, lower sodium intake has been shown to reduce both blood pressure (BP) and prevent atherosclerotic cardiovascular diseases (ASCVD). American Heart Association guidelines advocate daily sodium intake of less than 2,300 mg, but the estimated average sodium intake for Americans is 3,400 mg per day. In recent years, consumption of pre-processed and restaurant foods has substantially increased, and more than 75% of sodium in the average U.S. diet now comes from these sources. Our overall objectives are to: (1) evaluate the efficacy of a dietary sodium mobile application intervention on reducing BP, (2) establish that the improvement in BP is directly related to the change in diet and body weight, and (3) optimize the intervention to demonstrate sustained effects on BP.

PI_NAMEs: DORSCH, MICHAEL  (contact);NALLAMOTHU, BRAHMAJEE K

PROGRAM_OFFICER_NAME: MINTZER, KEITH A

PROJECT_TERMS: adaptive intervention;Adherence;Advocate;American;American Heart Association;Atherosclerosis;Blood Pressure;blood pressure reduction;Body Weight;Calories;Cardiovascular system;Chronic;Clinical;Consumption;Data;Development;Diagnosis;Diet;dietary;Dietary Component;Dietary Sodium;digital health;Disease;Education;efficacy evaluation;Electronic Health Record;Event;Food;Fostering;Future;Goals;group intervention;Guidelines;habituation;Health behavior;Home;Home Blood Pressure Monitoring;Hypertension;hypertensive;improved;Intake;Intervention;intervention effect;Knowledge;Learning;Life Style;Link;Measures;Mediating;Mediator;Medicine;Michigan;mobile application;Morbidity - disease rate;Notification;novel;nutrition;Participant;participant enrollment;patient engagement;Patient Recruitments;Patients;Potassium;prevent;Probability;Process;programs;prospective;Psychological reinforcement;Randomized;randomized trial;Randomized, Controlled Trials;Research;Restaurants;Self Management;Sodium;Sodium-Restricted Diet;Source;Technology;Testing;theories;Time;tool;trend;wearable device;wireless;Work

PROJECT_TITLE: A Just-In-Time Adaptive Mobile Application Intervention To Reduce Sodium Intake And Blood Pressure In Hypertensive Patients

STUDY_SECTION: SSPT

STUDY_SECTION_NAME: NHLBI Single-Site and Pilot Clinical Trials Study Section[SSPT(MA)]


NIH_SPENDING_CATS: Bioengineering;Cancer

PI_NAMEs: KAMM, ROGER D (contact)

PROJECT_TERMS: Achievement;Address;Administrator;Advisory Committees;Advocate;Agreement;anti-cancer research;Applications Grants;Award;Biochemical;Breast Cancer Patient;Cells;Cessation of life;Chromatin;Chromatin Structure;Circulation;Clinical Data;Collaborations;Communication;Communities;Computer Models;Dana-Farber Cancer Institute;Data;Data Commons;data quality;Data Set;data sharing;Development;Disease;Disease Progression;Disseminated Malignant Neoplasm;Ensure;Environment;Evaluation;Exposure to;Fostering;Gene Expression Profile;Grant;high resolution imaging;in silico;In Vitro;in vivo;Institution;Intervention;Knowledge;Lead;Leadership;Malignant Neoplasms;Mechanics;meetings;member;metadata standards;Mission;Modeling;Molecular;Monitor;multidisciplinary;Neoplasm Circulating Cells;Neoplasm Metastasis;neoplastic cell;Organ;Pathology;Patients;Pennsylvania;Phenotype;Pilot Projects;Program Reviews;programs;Proliferating;Protocols documentation;Publications;Quality Control;Records;Reporting;repository;Reproducibility;Research;research data dissemination;Research Personnel;Research Project Grants;Resource Sharing;response;Schedule;Scientist;Series;Signal Transduction;Site Visit;skill acquisition;Source;Stress;stressor;Stromal Cells;Structure;symposium;Technology;Texas;timeline;Tissues;transcriptome;transcriptomics;tumor microenvironment;Universities;Validation;Videoconferencing;virtual;Visit;web site;webinar;working group

PROJECT_TITLE: Admin: Mechanical determinants of organ-selective metastatic colonization, dormancy and outgrowth


ADMINISTERING_IC: AG

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: RICHARDSON

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF TEXAS DALLAS

PHR: Project Narrative  Decline in episodic memory – memory for unique events – is typical of healthy aging and, in a much more exaggerated fashion, of age-related neurodegenerative disorders such as Alzheimer’s Disease. The proposed research will contribute to the understanding of age-related differences in cognitive abilities, and the brain systems supporting them, that accompany age- and Alzheimer’s-related episodic memory decline. An important long-term goal of the research is to help pave the way for the development of interventions that will ameliorate memory decline by enhancing the memory processes that are most affected as a consequence of healthy and pathological aging.

PI_NAMEs: RUGG, MICHAEL D (contact)

PROGRAM_OFFICER_NAME: WAGSTER, MOLLY V

PROJECT_TERMS: Adult;Affect;Age;age difference;age effect;age group;age related;age related neurodegeneration;aged;Alzheimer like pathology;Alzheimer's Disease;Alzheimer's disease pathology;Anterior;Auditory;base;Behavioral;Brain;Categories;Characteristics;Clinical;Cognitive;cognitive ability;cognitive performance;cognitive process;cohort;design;Development;Episodic memory;Event;experience;Experimental Designs;experimental study;Face;follow-up;Functional Magnetic Resonance Imaging;Goals;healthspan;healthy aging;Impairment;Individual;Intervention;Judgment;Knowledge;life span;Location;Measures;Medial;Memory;memory encoding;Memory impairment;Memory Loss;memory process;memory retrieval;Methods;middle age;Modality;MRI Scans;Music;neural;neural patterning;Neuropsychological Tests;novel;older adult;pathological aging;Pattern;Performance;Photophobia;pre-clinical;Publishing;Quality of life;Rehabilitation therapy;Reporting;Research;Retrieval;Role;Sample Size;Sampling;Source;Speech;Stimulus;Stream;Structure;Support System;Testing;therapy development;Time;ventral visual stream;Water;young adult

PROJECT_TITLE: Neural Selectivity, Retrieval-Related Reinstatement, and Age-Related MemoryDecline

STUDY_SECTION: HCMF

STUDY_SECTION_NAME: Human Complex Mental Function Study Section[HCMF]


NIH_SPENDING_CATS: Bioengineering;Biotechnology

ORG_CITY: TUCSON

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: Bacterial synthetic multicellular systems and materials hold promise for many health-relevant ap- plications such as modular drug biosynthesis, living diagnostic devices, and synthetic bioﬁlm research models. Establishing control over the spatial, biochemical, and biophysical characteristics of synthetic consortia will be critical, but the key engineering tools such as synthetic cell-cell adhesins are still in their infancy. To close these major gaps, the proposed investigations will establish relevant synthetic tools, design principles, and modeling tools and deliver proof of principle of a new paradigm for modular engineering of synthetic multicellular bacterial consortia with desirable and tunable material properties and medical applicability.

PI_NAMEs: RIEDEL-KRUSE, HANS INGMAR (contact)

PROGRAM_OFFICER_NAME: ASLAN, KADIR

PROJECT_TERMS: 3-Dimensional;Adhesions;Anabolism;Area;Bacteria;Bacterial Adhesins;Bacterial Adhesion;bacterial community;Basic Science;Biochemical;Biocompatible Materials;biophysical model;biophysical properties;Biophysics;Cell Adhesion;cell growth;Cell surface;Cell-Cell Adhesion;Cells;Deposition;design;Development;Diagnostic;diagnostic assay;Diagnostic Equipment;diagnostic strategy;Drug Delivery Systems;Engineering;Escherichia coli;experimental study;Foundations;Future;Gene Expression Regulation;Genetic Models;Goals;Growth;Health;Image;in vivo;Industry;infancy;innovation;instrumentation;Investigation;Kinetics;Length;Literature;Logic;Medial;Medical;Medicine;meter;Methodology;Microbial Biofilms;Microfluidics;Microscopic;Modeling;Molecular;Morphology;Natural Compound;novel;optogenetics;Outcome;Pathway interactions;Pattern;Pharmaceutical Preparations;Play;Porosity;predictive modeling;Property;Proteins;Publications;Research;Resolution;self assembly;Signal Transduction;small molecule;Specificity;Structure;support tools;Surface;synthetic biology;System;Testing;three dimensional structure;tool;viscoelasticity;Work

PROJECT_TITLE: From synthetic bacterial adhesions to synthetic bacterial materials

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]


NIH_SPENDING_CATS: Bioengineering;Breast Cancer;Cancer;Genetics;Hematology;Women's Health Research

PROJECT_TERMS: Actomyosin;Adhesions;Animal Model;Batimastat;Blood flow;Blood Platelets;Blood Vessels;Breast Cancer Cell;breast cancer metastasis;cancer cell;CD44 gene;Cell Adhesion;Cell Survival;Cells;Cessation of life;Chromatin;Chromatin Structure;Circulation;Clinical;Coagulation Process;Computer Models;coping;coping mechanism;Coping Skills;Cytoskeleton;Dermis;design;druggable target;Endothelial Cells;Endothelium;Engineering;Environment;Event;Exhibits;experience;experimental study;Exposure to;extracellular;Extravasation;Fibrin;Generations;Genetic Complementation Test;Genetic Transcription;Geometry;Hematology;hemodynamics;high resolution imaging;Human;human disease;Immune;In Vitro;Individual;inhibitor;insight;Intervention;kinase inhibitor;knock-down;Knowledge;Lamin Type A;Lesion;Liver;Matrix Metalloproteinases;Measures;Mechanical Stress;Mechanics;Mediating;Microscopic;migration;Modeling;Molecular;monolayer;Morphology;Neoplasm Circulating Cells;Neoplasm Metastasis;neoplastic cell;novel therapeutic intervention;novel therapeutics;Nuclear;Organ;Organ Model;Outcome;overexpression;Peripheral;permissiveness;Phenotype;Physical environment;Population;pressure;prevent;Probability;Process;Proliferating;Property;Proteolysis;Resolution;Rho-associated kinase;Role;self assembly;shear stress;Signal Pathway;single-cell RNA sequencing;Source;Stress;stressor;Stromal Cells;Study models;System;Techniques;Testing;Therapeutic;Thrombus;Tissues;transcriptomics;triple-negative invasive breast carcinoma;Tropism

PROJECT_TITLE: Project1: The role of intravascular pressure and shear stress on tumor cell arrest, survival and proliferation in the microvascular niche


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cost Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: HISHINUMA, EARL SHIGEMI (contact)

PROJECT_TERMS: Acceleration;Address;Adoption;Affect;Area;Biometry;Burn injury;career;Chronic;Clinical Research;clinically relevant;Communication;community collaboration;community engagement;Community Outreach;community partners;Cost Effectiveness Analysis;Data;Data Analyses;Data Collection;Data Science;design;Development;Disparity;economic evaluation;Education;Effectiveness;efficacy trial;Environment;Epidemiology;ethnic health disparity;Evaluation;Extramural Activities;Filipino;Fostering;Funding;Goals;Grant;Hawaii;Health;Health behavior;health disparity;health economics;Health Policy;Health Status;Healthcare;Healthy People 2020;Human Resources;improved;Indigenous;innovation;Institution;Institutionalization;Intervention;Knowledge;large datasets;Marketing;medical schools;medically underserved population;Mentors;Methodology;Methods;minority health;minority health disparity;Morbidity - disease rate;mortality;Native Hawaiian;Native Hawaiian or Other Pacific Islander;novel;outreach program;Pacific Islander;Participant;Persons;Pilot Projects;Play;Population;Preparation;Process;Productivity;professor;programs;Psychiatry;Psychometrics;Publications;Qualifying;racial disparity;recruit;Reduce health disparities;Research;research and development;Research Design;Research Infrastructure;Research Methodology;Research Personnel;Research Project Grants;Research Proposals;Resources;Role;Science;Secure;Services;skills;social health determinants;stem;Talents;tool;Training;Training and Education;Translational Research;Underserved Population;United States Dept. of Health and Human Services;Universities;Visualization;Vulnerable Populations;Work

PROJECT_TITLE: Biostatistics, Epidemiology, and Research Design Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative. The Washington University T32 postdoctoral training grant “Translational Imaging in Radiopharmaceutical Sciences” (abbreviated as “TIRS”) is a multidisciplinary initiative to train the next generation of PET molecular imaging scientists to design, develop, and translate diagnostic agents for imaging of neurodegenerative diseases and ADRDs. To accomplish this novel training mission, the T32 TIRS program brings leading scientists from 12 departments of Washington University on a single platform to provide proposed multidisciplinary training. Successful accomplishment of training goals (as outlined in program plan) will deliver molecular PET imaging research scientists who would be transitioning into faculty positions nationwide and will be expected to serve the field of diagnostic nuclear medicine in neuroscience for several decades.

PI_NAMEs: BENZINGER, TAMMIE LEE SMITH;SHARMA, VIJAY  (contact);TU, ZHUDE

PROGRAM_OFFICER_NAME: LUO, YUAN

PROJECT_TITLE: Translational Imaging Research Program in Radiopharmaceutical Sciences


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Lung;Social Determinants of Health

ORG_CITY: CHAPEL HILL

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative Epidemiological evidence indicates a significant association between ambient PM exposures in China and increased incidence or severity of respiratory infections. Linked human in vivo and mechanistic in vitro studies are needed to understand the effects of PM on respiratory immune responses and susceptibility to infection. Our quantitative and integrated translational research approaches will be able to determine the effects of “China PM” on respiratory mucosal host defense function in humans in vitro (UNC Projects) and in vivo (Chinese Collaborative Project).

PI_NAMEs: ALEXIS, NEIL  (contact)

PROGRAM_OFFICER_NAME: NADADUR, SRIKANTH

PROJECT_TERMS: Acute;Address;Adverse effects;Affect;Age;Air Pollutants;Air Pollution;air sampler;airway immune response;antimicrobial;Area;arm;Biochemical;Bioenergetics;Biological Products;Biological Response Modifiers;Bronchoalveolar Lavage;Cell Physiology;cell type;Cells;Cessation of life;Child;China;Chinese;Chronic;Clinical;Collaborations;Collection;Country;Data;defense response;Disease;Epidemiology;epidemiology study;Epithelial Cells;Epithelium;Equilibrium;experimental study;Exposure to;fighting;fine particles;Gene Expression;Genomics;global health;Glycolysis;Health;healthy volunteer;Homeostasis;Host Defense;Human;Human Volunteers;Immune;immune function;immune health;Immune system;Immune System Diseases;Immunologic Markers;immunoregulation;In Vitro;in vitro testing;in vivo;Incidence;Individual;Infection;Inflammation;Inflammatory;Innate Immune Response;innovation;Invaded;Knowledge;Leukocytes;Life;Link;Lung;Macrophage;Measures;Mediating;Mediator;Medical;Metabolism;Mitochondria;Modeling;Modification;monocyte;Mucosal Immune Responses;Mucous Membrane;Nasal Epithelium;nasal microbiome;Nose;novel;Oxidative Phosphorylation;pathogen;Phenotype;pollutant;Pollution;Predisposition;premature;Production;recruit;Respiration;respiratory;Respiratory Mucosa;Respiratory System;Respiratory Tract Infections;response;Role;Sampling;Severities;Sputum;Structure of mucous membrane of nose;Surface;System;Translational Research;Universities;Viral;volunteer

PROJECT_TITLE: PM exposure and changes in respiratory host defense responses

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OBT-M(50)R]


NIH_SPENDING_CATS: Bioengineering;Breast Cancer;Cancer;Digestive Diseases;Liver Disease;Skin Cancer;Women's Health Research

PHR: Project 2: NARRATIVE Metastatic organ colonization by circulating tumor cells in vivo differs in mechanical challenge between organ sites and single-cell and collective metastasis modes. Using intravital microscopy of single or clustered tumor cells during liver and skin metastasis, we will identify novel molecular mechanisms of mechano-adaptation securing survival, dormancy and outgrowth and potential intervention points to prevent metastasis.

PI_NAMEs: FRIEDL, PETER  (contact)

PROJECT_TERMS: Actomyosin;Adherens Junction;Adhesions;Basement membrane;Blood Vessels;Breast Cancer Cell;cancer cell;Cathepsins;CD44 gene;Cell Cycle Arrest;Cell Death;cell motility;Cell Nucleus;Cell Reprogramming;Cell Survival;Cell-Cell Adhesion;Cells;Cellular Stress;Chromatin;Chromatin Structure;Circulation;Clinical;Coagulation Process;Computer Models;coping;Cytometry;Cytoplasm;Cytoskeleton;Data;Distant;Distant Metastasis;Down-Regulation;early onset;Endothelium;Engineering;Environment;experience;Extravasation;fitness;Growth;in silico;in vivo;in vivo Model;Individual;Intercellular Junctions;Intervention;intravital microscopy;Kinetics;Lamin Type A;Liquid substance;live cell microscopy;Liver;Matrix Metalloproteinases;mechanical properties;Mechanical Stress;Mechanics;Mediating;Melanoma Cell;Metastatic Neoplasm to the Liver;Microanatomy;migration;Modeling;Molecular;Molecular Conformation;Molecular Target;Monitor;mouse model;Movement;multiphoton microscopy;Mus;Neoplasm Circulating Cells;Neoplasm Metastasis;neoplastic cell;novel;Nuclear;Organ;Outcome;Pathway interactions;Peptide Hydrolases;prevent;Probability;Process;programs;Proliferating;Regulation;response;Scheme;Secure;shear stress;Site;Skin;Skin Metastasis;Solid;Stress;success;Survival Rate;System;Testing;Tissue imaging;tissue stress;Tissues;transcriptomics;triple-negative invasive breast carcinoma;Variant;vascular bed;Vascular remodeling;vascular stress;Vulnerable Populations

PROJECT_TITLE: Project 2: Mechanochemical Mechanisms and Vulnerabilities of Individual and Collective Organ-Preferential Metastasis In Vivo


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: GOEBERT, DEBORAH A. (contact)

PROJECT_TERMS: Acceleration;Adoption;Advisory Committees;Advocate;Basic Science;Behavioral;Belief;Biometry;Categories;Clinical Research;Communication;Communities;community academic partnership;community advisory board;community engagement;Community Health;community organizations;Community Outreach;community partners;community partnership;Creativeness;Development;Disease;Dissemination and Implementation;Educational workshop;Elements;Eligibility Determination;Ensure;Epidemiology;ethnic diversity;experience;Federally Qualified Health Center;Filipino;Goals;Hawaii;Health;health disparity;Healthcare Systems;improved;Indigenous;innovation;institutional capacity;Institutionalization;Intervention;Investments;Knowledge;Link;Mainstreaming;medically underserved population;member;Mentors;Methods;Native Hawaiian;Native Hawaiian or Other Pacific Islander;Participant;Personal Satisfaction;Persons;Pilot Projects;Population;practice-based research network;preference;Productivity;programs;racial diversity;recruit;Reduce health disparities;Registries;Research;Research Design;Research Infrastructure;Research Personnel;social;supportive environment;tool;Translational Research;Trust;Underrepresented Populations;underserved community;United States National Institutes of Health;user-friendly;Vulnerable Populations;Work

PROJECT_TITLE: Community Engagement and Outreach Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

PHR: The University of Arizona Training Program to Advance Translational Research on Alzheimer's Disease and AD Related Dementias is designed to create a workforce capable of developing therapeutics to address the national and global crisis of Alzheimer’s disease.

PI_NAMEs: BRINTON, ROBERTA EILEEN (contact)

PROGRAM_OFFICER_NAME: CHAKROBORTY, SHREAYA

PROJECT_TERMS: Alzheimer's disease related dementia;Translational Research

PROJECT_TITLE: Translational Research in Alzheimer's Disease and related Dementias (TRADD)

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development for Established Investigators and Conference Grants Study Section[AGCD-4]


PHR: PROJECT NARRATIVE Part of the NIH mission is to seek fundamental knowledge about the nature and behavior of living systems, and to apply this knowledge to enhance human health and lengthen life. Our proposed research is relevant to this mission because it seeks to understand how plants and microorganisms, some of which are medically-relevant pathogens, use the phytochrome (Phy) family of photoreceptors to gather information about their light environment and adjust their growth and development accordingly. In addition, given the widespread biotechnological use of Phy variants both as novel fluorophores and as engineered photoswitches, a further understanding of Phy structure and photochemistry should accelerate the development of advanced optogenetic tools for tissue imaging and the precise spatial and temporal control of cellular events.

PI_NAMEs: VIERSTRA, RICHARD DAVID (contact)

PROGRAM_OFFICER_NAME: FLICKER, PAULA F

PROJECT_TERMS: absorption;Acceleration;Advanced Development;Agriculture;Architecture;Back;Behavior;Bilin;Binding;Biochemical;Biology;Biotechnology;chromophore;Collection;comparative;conformer;Coupled;Cryoelectron Microscopy;Crystallography;Data;Deuterium;dimer;driving force;Ecosystem;Electrons;Engineering;Environment;Event;Evolution;Family;fluorophore;Genetic Transcription;Goals;Growth and Development function;Head;Health;Human;human pathogen;Hydrogen;improved;Influentials;information gathering;Isomerism;Kinetics;Knowledge;Length;Life;Light;light intensity;Link;Maps;Mass Spectrum Analysis;Measures;Medical;member;Membrane Proteins;microbial;microorganism;Microscopic;Mission;Modality;Modeling;Molecular Conformation;Nature;novel;optogenetics;Organism;Output;oxidation;Paint;particle;pathogen;Pathway interactions;Perception;Performance;photoactivation;Photochemistry;Photons;Photoperiod;Photoreceptors;Physiological Processes;Phytochrome;plant growth/development;Plant Model;Plants;Positioning Attribute;Process;Protein Isoforms;protein-histidine kinase;Proteins;Reaction;Reagent;Research;Signal Transduction;Source;Structure;Surface;Synchrotrons;Tail;Temperature;Temperature Sense;Tetrapyrroles;three dimensional structure;three-dimensional modeling;Time;Time Perception;Tissue imaging;tool;transcription factor;Transcription Repressor;United States National Institutes of Health;Variant;Work;X-Ray Crystallography;x-ray free-electron laser

PROJECT_TITLE: Phytochromes: Structural Perspectives on Photoactivation and Signaling

STUDY_SECTION: MSFA

STUDY_SECTION_NAME: Macromolecular Structure and Function A Study Section[MSFA]


NIH_SPENDING_CATS: Cancer;Clinical Research;Data Science;Networking and Information Technology R&D (NITRD);Precision Medicine;Prevention

ORG_CITY: HOUSTON

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: Project Narrative We propose to establish a Coordinating and Data Management Center (CDMC) for the Program on the Translational and Basic Science Research in Early Lesions (TBEL), which is being established to undertake various translational and basic science studies to provide fundamental knowledge on the mechanisms driving or restraining early cancers. The proposed CDMC will support critical administrative, regulatory, managerial, logistics, data-analytic, computational, and financial functions of the TBEL Program.

PI_NAMEs: LI, LIANG ;YUAN, YING  (contact)

PROGRAM_OFFICER_NAME: PATRIOTIS, CHRISTOS F

PROJECT_TERMS: Adopted;Age;Area;Automobile Driving;Basic Science;biobank;Bioinformatics;Biological Specimen Banks;biomarker development;biomarker identification;Biometry;Breast;Budgets;cancer diagnosis;cancer type;Center for Translational Science Activities;Cervical;chronic pancreatitis;Clinical;Clinical Management;Clinical Trials;Clinical Trials Data Monitoring Committees;Collaborations;Colon;Communication;Communities;Complex;Computer software;Consent Forms;cost;Data;Data Analytics;Data Coordinating Center;data curation;data management;Data Science;data tools;density;Detection;Development;Diabetes Mellitus;Diagnosis;DNA Sequence Alteration;Early Diagnosis;Epidemiologic Factors;experience;Faculty;Funding;Goals;healthcare burden;Human Resources;Image;Image Analysis;image archival system;Immunocompetence;improved;Indolent;Industry;Inflammation;Information Technology;Infrastructure;innovation;Knowledge;Leadership;Lesion;Link;Logistics;Machine Learning;Malignant neoplasm of pancreas;Malignant Neoplasms;Mediating;Methods;Molecular;Molecular Profiling;Monitor;mortality;Multicenter Studies;novel;operation;overtreatment;Pathology;Patient risk;patient stratification;Patients;personalized medicine;Preparation;Procedures;Process;programs;protocol development;Protocols documentation;repository;Research;Research Design;Research Methodology;Research Personnel;response;restraint;risk prediction;Screening for cancer;single cell analysis;Software Tools;Specialist;statistics;Stress;Technology;Testing;Therapeutic Effect;Time;Tissues;tool;Translational Research;Translations;United States National Institutes of Health;University of Texas M D Anderson Cancer Center;Visualization;web platform;Work

PROJECT_TITLE: Coordinating and Data Management Center  for Translational and Basic Science Research in Early Lesions


NIH_SPENDING_CATS: Cancer;Clinical Research;Data Science;Networking and Information Technology R&D (NITRD)

ORG_CITY: BUFFALO

ORG_NAME: ROSWELL PARK CANCER INSTITUTE CORP

PHR: Project Narrative While advances in cancer therapeutics have resulted in remarkable clinical responses in some patients, acquired resistance remains one of the biggest challenges towards expanding the clinical benefits to more patients. Tackling acquired therapy resistance will require collaborative efforts to elucidate resistance mechanisms, characterize the tumor microenvironment, discover new targets, identify predictive biomarkers, evaluate combination therapies, and develop real-time monitoring approaches. The goal of our proposed Coordinating and Data Management Center (CDMC) application is to coordinate the activities across the Acquired Resistance to Therapy Network (ARTNet), and to manage, integrate and disseminate the data and resources generated through the network. Leveraging cutting-edge multi-disciplinary team approaches, we will support the ARTNet to inform new strategies that can be better translated to overcome significant challenges in acquired resistance to cancer therapies.

PI_NAMEs: GOODRICH, DAVID W.;HUTSON, ALAN DAVID (contact);LIU, SONG

PROGRAM_OFFICER_NAME: VENKATACHALAM, SUNDARESAN

PROJECT_TERMS: Acceleration;Address;Adopted;biobank;Bioconductor;Bioinformatics;biomedical informatics;Biometry;Cancer Center Support Grant;cancer therapy;Clinical;cloud based;Collaborations;Combined Modality Therapy;Communities;community engagement;Comprehension;Computer software;cost;Data;data acquisition;Data Coordinating Center;data ecosystem;data harmonization;data integration;data management;data repository;Data Science;Data Set;data sharing;data sharing networks;data standards;Databases;Development;Drug Kinetics;Drug resistance;drug sensitivity;Ecosystem;Ensure;experience;Fostering;Funding;genomic data;Goals;Hand;Immunooncology;Immunotherapy;improved;Informatics;Information Technology;Infrastructure;interoperability;Malignant Neoplasms;Methods;multidisciplinary;Multiomic Data;National Human Genome Research Institute;open source;operation;outreach;Patients;Pharmacodynamics;pharmacokinetics and pharmacodynamics;Police;Policies;pre-clinical;predictive marker;Principal Investigator;Productivity;PubMed;quality assurance;real time monitoring;Records;Reproducibility;Research;Research Personnel;Research Project Grants;Resistance;resistance mechanism;Resource Sharing;Resources;response;Services;shared repository;support network;Text;Therapeutic;therapy resistant;tool;Translating;translational oncology;tumor microenvironment;United States National Institutes of Health;virtual;Visualization

PROJECT_TITLE: Coordinating and Data Management Center for Acquired Resistance to Therapy Network


NIH_SPENDING_CATS: Bioengineering;Cancer;Cancer Genomics;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

PI_NAMEs: SHENOY, VIVEK  (contact)

PROJECT_TERMS: 3-Dimensional;Actomyosin;Adhesions;Adhesives;Affect;Basement membrane;biophysical model;Blood Platelets;Blood Vessels;cancer cell;Cell Adhesion;Cell Adhesion Molecules;Cell Death;Cell model;cell motility;Cell Nucleus;Cell Survival;Cells;Characteristics;Chromatin;Chromatin Structure;computerized tools;coping;Coupling;Cytoskeleton;Data Analytics;Dimensions;DNA Damage;Elements;Endothelial Cells;Endothelium;Environment;Epigenetic Process;experimental study;extracellular;Extracellular Matrix;Extravasation;Feedback;Fractals;Gene Expression;Gene Expression Regulation;Genetic Transcription;Genome;Grain;Growth;Histone Deacetylation;Image;In Vitro;in vivo;Individual;innovation;insight;Invaded;Lamin Type A;Lamins;Length;Liquid substance;Liver;Mechanical Stress;Mechanics;mechanotransduction;Mediating;migration;Modeling;Modification;Molecular;Morphology;multi-scale modeling;Myosin Type II;Neoplasm Metastasis;neoplastic cell;Nuclear;Nuclear Envelope;Nuclear Lamina;nucleocytoplasmic transport;Organ;Pattern;Peptide Hydrolases;Phenotype;Process;Property;Regulation;response;Role;Rupture;Shapes;shear stress;simulation;Skin;Solid;Stress;stressor;Structure;Theoretical model;three-dimensional modeling;Time;Tissues;tool;transcriptome;Tumor Cell Migration

PROJECT_TITLE: Core1:  Computational