ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: BALTIMORE

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Though it is known that intraoperative hypotension occurs at an alarming frequency in patients at the extremes of age undergoing general anesthesia, the underlying mechanisms thereof remain unclear. In order to prevent the significant morbidity and mortality associated with intraoperative hypotension in this population, it is incumbent upon us to determine unique properties of young and aged individuals that put them at increased risk. We propose to use an integrated in vivo and in vitro approach to determine how vascular mechanisms lead to the increased risk of intraoperative hypotension in this population, allowing identification of organ perfusion - based definitions of hypotension, optimal treatment strategies for when hypotension occurs, and development of safer anesthesia regimens.

PI_NAMEs: WHITAKER, EMMETT E (contact)

PROGRAM_OFFICER_NAME: JUSTINOVA, ZUZANA

PROJECT_TERMS: Address;Adolescent;Adult;Age;Age Years;aging population;Anesthesia procedures;Anesthetics;Biomechanics;Blood Pressure;Blood Vessels;cerebral artery;cerebral autoregulation;Cerebrovascular Circulation;constriction;Data;Development;Ensure;Equilibrium;experience;Exposure to;Foundations;Frequencies;General Anesthesia;General anesthetic drugs;Goals;Health Care Costs;hemodynamics;hypoperfusion;Hypotension;Impairment;improved;In Vitro;in vivo;Infant;Injury;insight;Lead;Mesenteric Arteries;middle cerebral artery;Morbidity - disease rate;mortality;neonate;Norepinephrine;older adult;Operative Surgical Procedures;optimal treatments;Organ;Patient Care;Patients;Perfusion;Perioperative Care;Population;preservation;prevent;programs;Property;Public Health;Publishing;Rattus;Regimen;Research;Risk;Role;treatment strategy;young adult

PROJECT_TITLE: Vascular Determinants of Anesthesia-Induced Hypotension at the Extremes of Age

STUDY_SECTION: MRAD

STUDY_SECTION_NAME: Maximizing Investigators' Research Award - D Study Section[MRAD]


ADMINISTERING_IC: AR

ARRA_FUNDED: N

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Biomedical Imaging;Clinical Research;Pediatric

ORG_CITY: PHILADELPHIA

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

ORG_STATE: PA

PHR: NARRATIVE The proposed research is relevant to public health because spondyloarthritis is the most common form of childhood arthritis in large parts of the world and there is a critical need for studies to evaluate existing and emerging targeted therapies for this understudied condition as well as physician scientists to conduct them. This project is directly aligned with the program announcement (PA-20-186) as the goals are to expand the training, mentoring, and career development of physician scientists pursuing patient-oriented research in rheumatology and to facilitate the design of efficacy and effectiveness studies of emerging targeted therapies such as inhibitors of the IL-17/IL-23 and JAK-STAT pathways.

PI_NAMEs: WEISS, PAMELA FITCH (contact)

PROGRAM_OFFICER_NAME: PARK, HEIYOUNG

PROJECT_TERMS: Accounting;Address;Adolescent;Adult;Advisory Committees;Anatomy;Ankylosing spondylitis;Arthritis;Bone Marrow;career development;Caring;Child;Child Care;Childhood;Chronic Childhood Arthritis;Classification;Clinical;clinical care;Clinical Research;Clinical Trials;Data;Data Sources;design;Diagnosis;diagnostic accuracy;diagnostic biomarker;Diagnostic Imaging;Diffusion;Diffusion Magnetic Resonance Imaging;Disease;Disease remission;Early Diagnosis;Edema;Educational process of instructing;effectiveness study;efficacy study;Ensure;Environment;epidemiology study;experience;Faculty;Functional impairment;Funding;Goals;IL17 gene;Image;Image Analysis;imaging biomarker;imaging study;Imaging Techniques;improved;indexing;Inflammation;Inflammatory;inhibitor;innovation;interleukin-23;International;Joints;Lesion;Location;Magnetic Resonance Imaging;Mentors;Methodology;next generation;NIH Program Announcements;novel;Outcome;Pathologic;Pathology;Pathway interactions;patient oriented research;Pediatric Radiologist;peer;Pelvis;Physicians;Population;Predictive Value;prevent;programs;progression risk;Public Health;quantitative imaging;Recommendation;Research;Research Methodology;Research Personnel;rheumatologist;Rheumatology;Sacroiliac joint structure;Scientist;skills;Societies;Specificity;Spondylarthritis;subchondral bone;success;targeted treatment;Techniques;tertiary care;Testing;Time;tool;Training;Work

PROJECT_TITLE: Mentoring and Patient Oriented Research in Juvenile Spondyloarthritis

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Clinical Research;Digestive Diseases;Genetics;Infectious Diseases

ORG_CITY: LA JOLLA

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: Narrative Macrophages are powerful cellular components of innate immunity; on the one hand they play a pivotal role in defending against pathogens, cancerous cells and other harmful stimuli by being immunoreactive, and on the other hand, they contribute to tissue homeostasis by being immunotolerant to harmless antigens and beneficial microbes. Too much or too little of either of these two states (immunoreactive vs. tolerant) can serve as triggers and perpetuate diverse human diseases. Using novel computational approaches, we have charted a formal model for macrophage response to infections, and revealed hitherto unknown important genes that regulate the process of macrophage polarization; we plan to identify potential therapeutic targets that can reprogram macrophage response in disease states.

PI_NAMEs: GHOSH, PRADIPTA  (contact);SAHOO, DEBASHIS

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Acute;Acute Disease;adaptive immune response;Antigens;Arthritis;Atherosclerosis;Automobile Driving;beneficial microorganism;Big Data;biobank;Biological;Biological Markers;Biological Models;Biology;Body System;bone;Cancerous;Cell Physiology;cell type;Cells;Cellular biology;chemically induced colitis;Chemicals;Chronic Disease;Coculture Techniques;Colitis;Collection;Colorectal;Colorectal Adenoma;Colorectal Cancer;Communities;Complex;Computational Biology;computerized tools;Computing Methodologies;Confusion;Consensus;cytokine;Data;Data Set;Dedications;design;Development;Diabetes Mellitus;Discipline;Disease;disease model;disease prognosis;diverse data;Eating;Enzyme-Linked Immunosorbent Assay;Epithelium;Event;Evolution;Exhibits;experimental study;Exposure to;functional genomics;Funding Mechanisms;gastrointestinal infection;Gene Cluster;Gene Deletion;Gene Expression;Gene Expression Profile;Genes;Genetic Models;Genetic Screening;genetic signature;Goals;Greek;Health;Heterogeneity;Homeostasis;Human;human disease;human model;Immune;Immune system;Immunologics;Immunology;immunoreactivity;Infection;Infectious colitis;Inflammation;Inflammatory;Inflammatory Bowel Diseases;Innate Immune Response;innovation;Knowledge;Lead;Liver Fibrosis;Machine Learning;machine learning model;Macrophage;Malignant Neoplasms;Maps;Measures;Metabolic syndrome;Methods;Microbe;Modeling;Molecular;monocyte;Morphologic artifacts;mouse model;Mus;National Institute of Allergy and Infectious Disease;Natural Immunity;Noise;Nomenclature;nonalcoholic steatohepatitis;novel;Occupations;Organ;Organoids;Outcome;pathogen;Pathogenesis;Pathologic;Patients;Phase 0 Trial;Physicians;Physiological;Physiology;Play;Process;prognostication;programs;Reaction;repaired;Research;Resources;response;Role;Scientist;Sepsis;Series;Stimulus;Structure;success;T-Lymphocyte;targeted treatment;Testing;Therapeutic;therapeutic target;tissue injury;Tissues;TLR4 gene;tool;transcriptome sequencing;transcriptomics;Validation;validation studies

PROJECT_TITLE: Macrophage Polarization in Response to Infections and Inflammation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IMM-T(57)S]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dementia;Dissemination and Implementation Research;Health Services;Neurodegenerative;Neurosciences;Palliative Care

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE Communication about goals of care is one of the most important aspects of care for patients with Alzheimer’s disease and related dementias (ADRD) and their family caregivers, yet the lack of this communication is a major shortcoming in our healthcare system. We propose an NIH Stage III hybrid efficacy-effectiveness randomized trial to evaluate a novel intervention that promotes and enhances goals-of-care discussions for patients with ADRD and their family caregivers. We hypothesize the intervention will improve documentation of goals-of-care discussions and other important patient-centered outcomes for these patients and their families.

PI_NAMEs: ENGELBERG, RUTH ANN;KROSS, ERIN KATHRYN (contact)

PROGRAM_OFFICER_NAME: GERALD, MELISSA S

PROJECT_TERMS: Address;Adoption;Adult;Alzheimer's disease patient;Alzheimer's disease related dementia;Biometry;Caring;Chronic Disease;Clinic Visits;Communication;comparison intervention;Complex;Consensus;Data;Decision Making;Documentation;effectiveness evaluation;effectiveness trial;electronic health data;Electronic Health Record;end of life;end of life care;Enrollment;Evaluation;Exclusion;experience;Face;Family;Family Caregiver;Family member;Future;Goals;Grant;health care service utilization;Health system;Healthcare Systems;Hybrids;implementation facilitation;implementation intervention;implementation science;improved;Informatics;insight;Intervention;intervention effect;Interview;Maintenance;Measurement;Measures;Methods;Monitor;mortality;National Institute on Aging;Natural Language Processing;novel;older patient;Outcome;Outpatients;Palliative Care;participant enrollment;Patient Admission;Patient Care;patient oriented;Patient-Centered Care;Patient-Focused Outcomes;Patients;Policies;Population;Positioning Attribute;primary outcome;programs;psychological distress;Quality of Care;Randomized;randomized effectiveness trial;randomized trial;Reporting;Research;secondary outcome;Structure;Surveys;symposium;System;Testing;therapy design;treatment as usual;United States National Institutes of Health

PROJECT_TITLE: Hybrid efficacy-effectiveness trial to promote goals-of-care discussions for patients with Alzheimer's disease and related dementias and their family caregivers


NIH_SPENDING_CATS: Antimicrobial Resistance;Emerging Infectious Diseases;Infectious Diseases

PHR: PROJECT NARRATIVE This research is highly relevant to public health because infections caused by the bacteria Staphylococcus aureus are common, serious, and difficult to treat. Our proposal will advance a new strategy to aid development of much-needed new antistaphylococcal therapies.

PI_NAMEs: DOWD, CYNTHIA SCHIECK;JEZ, JOSEPH MARTIN;ODOM JOHN, AUDREY RAGAN (contact)

PROGRAM_OFFICER_NAME: XU, ZUOYU

PROJECT_TERMS: 3-Dimensional;analog;Anti-Bacterial Agents;anti-microbial drug;Antibiotics;antimicrobial;Bacteria;beta-Lactams;Biochemical;Biological;Biological Assay;candidate identification;Cefazolin;Chemical Models;Chemical Structure;Chemicals;Clinical;combat;Crystallography;design;Development;Disease;drug development;drug discovery;Drug Kinetics;Ensure;esterase;esterase A;Esterification;Esters;experience;Genus staphylococcus;Goals;Human;improved;In Vitro;in vivo;Infection;inhibitor;Intestinal Absorption;iterative design;Kinetics;Knowledge;Label;lipophilicity;methicillin resistant Staphylococcus aureus;microbial;Microbial Drug Resistance;microbiome;Modification;Molecular;Mutagenesis;Nafcillin;novel;novel strategies;Organism;Pathogenesis;Pathogenicity;Penetration;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacologic;phosphonate;Planets;pre-clinical;Prodrugs;Property;Proteins;Public Health;Publishing;Research;Resistance;Resolution;Serum;Site;Specificity;Staphylococcal Infections;Staphylococcus aureus;structural biology;Structure;Structure-Activity Relationship;success;System;targeted agent;Therapeutic;undecaprenyl pyrophosphate

PROJECT_TITLE: Structure-based microbially targeted prodrugs

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AIDC-V(02)]


ED_INST_TYPE: SCHOOLS OF PHARMACY

ORG_CITY: AUSTIN

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

ORG_STATE: TX

PHR: Project Narrative Proteins-only biomolecular condensates are a crucial part of normal cellular processes and their mis-regulation is at the heart of various pathologies. Unfortunately, current understanding on what sequence motifs promote the assembly of such condensates and the biophysical principles that regulate their composition and dynamics has been limited. Discoveries from this work will provide a framework in fundamental understanding of these condensates and bring new opportunities to prevent, diagnose, and treat condensate-driven diseases.

PI_NAMEs: GUAN, JUAN  (contact)

PROGRAM_OFFICER_NAME: CHO, THOMAS Y

PROJECT_TITLE: Mechanisms of Assembly and Functional Regulation in Non-canonical Biomolecular Condensates

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: GREEN BAY

ORG_NAME: ST. VINCENT HOSPITAL

ORG_STATE: WI

PHR: Project Narrative Currently, cancer clinical research is predominantly performed at academic medical centers, partially due to the operational challenges and limitations of resources at community sites. A core premise of the NCORP network is expanding the reach and execution of cancer control, prevention and cancer care delivery research deeper into community settings which will diversify trial participants and accelerate promising treatments through clinical trials and into broader use. The CROWN Consortium supports the NCORP mission by leveraging a network of community sites throughout Wisconsin and northern Michigan with a shared mission, training, procedures, and clinical resources, and will be able to provide the necessary clinical support to offer improved enrollment numbers and diversity, enhancing study outcomes and reducing disparities.

PI_NAMEs: JASLOWSKI, ANTHONY J (contact)

PROGRAM_OFFICER_NAME: WHITE, VANESSA

PROJECT_TERMS: Academic Medical Centers;Acceleration;Address;African American;Aftercare;Amish;anti-cancer research;Area;base;cancer care;Cancer Center;Cancer Control;cancer health disparity;Cancer Hospital;care delivery;Catchment Area;Clinical;clinical imaging;Clinical Research;Clinical Skills;Clinical Trials;Collaborations;Communities;Community Health;Community Networks;Community Outreach;community setting;County;Data;Disparity;disparity reduction;Education;empowerment;Enrollment;ethnic minority;ethnic minority population;Evaluation;expectation;experience;Feedback;Geography;Goals;Health care facility;health professional shortage areas;Healthcare;Hispanic Populations;Hospitals;Image;improved;Infrastructure;Institution;Latino Population;Lead;Location;Malignant Neoplasms;Medical Oncology;Medically Underserved Area;member;Mentors;Michigan;minority communities;Minority Groups;Mission;multidisciplinary;National Cancer Institute;Outcome;outcome disparities;Outcome Study;Palliative Care;Participant;Patient Compliance;patient population;Patient Representative;patient retention;Patients;Pediatric Oncology;Performance;Population;Population Heterogeneity;Prevention;Procedures;Process;programs;protocol development;Protocols documentation;Qualifying;racial minority;Radiation Oncology;recruit;Research;Research Design;Research Infrastructure;Research Personnel;Resource Sharing;Resources;Rural;rural area;Rural Minority;Rural Population;Saints;screening;Sister;Site;Structure;Subgroup;success;Training;underserved community;Underserved Population;urban minority;Urban Population;Vision;Wisconsin

PROJECT_TITLE: Cancer Research of Wisconsin and Northern Michigan (CROWN) Consortium


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Digestive Diseases;Genetics;Human Genome;Pancreatic Cancer;Rare Diseases

ORG_CITY: BOSTON

ORG_NAME: DANA-FARBER CANCER INST

ORG_STATE: MA

PHR: Project Narrative Transcriptional cell states are correlated with clinical outcomes and therapeutic sensitivity in pancreatic cancer, but the mechanisms regulating cell state specification and tumor cell plasticity are not well understood. This research proposal examines the mechanisms by which TGF-β specifies the pancreatic cancer basal cell state, investigates how TGF-β-mediated cellular plasticity drives chemo-resistance in organoid models and serially collected metastatic biopsies analyzed with single-cell RNA-sequencing, and applies pharmacologic and genetic screening techniques in isogenic state-variant pancreatic cancer organoid models to identify cell state-specific therapeutic vulnerabilities. These studies will advance our understanding of how tumor cell states and cellular plasticity regulate therapeutic sensitivity in pancreatic cancer and uncover new avenues for therapeutic development.

PI_NAMEs: RAGHAVAN, SRIVATSAN  (contact)

PROGRAM_OFFICER_NAME: LIM, SUSAN E

PROJECT_TERMS: Address;Adopted;Advanced Development;Advisory Committees;Area;Award;Basal Cell;Basal Cell Cancer;Biological Markers;Biomedical Engineering;Biopsy;Cancer Biology;career development;Cells;Chemoresistance;chemotherapeutic agent;chemotherapy;Cholangiocarcinoma;Chronic;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Committee Members;CRISPR screen;Dana-Farber Cancer Institute;Disease;Drug resistance;drug sensitivity;effective therapy;Environment;Evolution;Exhibits;Faculty;Genetic;Genetic Screening;Genetic Transcription;Goals;Heterogeneity;Immune;in vivo;Infrastructure;Inpatients;insight;Knock-out;Laboratories;Libraries;Ligands;MADH2 gene;MADH4 gene;Malignant neoplasm of gastrointestinal tract;Malignant neoplasm of pancreas;Malignant Neoplasms;MAP Kinase Gene;MAP3K7 gene;MAPK8 gene;Mediating;Medical Oncologist;medical schools;member;Mentors;Mentorship;Modeling;Molecular;neoplastic cell;non-genetic;Oncology;Organoids;Outcome;Outpatients;overexpression;p38 Mitogen Activated Protein Kinase;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;pancreatic ductal adenocarcinoma model;Patient Care;Patients;pharmacologic;Phenotype;Physicians;PIK3CG gene;predict clinical outcome;Prognosis;receptor;Regulation;Research;research and development;Research Personnel;Research Proposals;Resistance;resistance mechanism;Role;Sampling;Scientific Advances and Accomplishments;Scientist;Selection for Treatments;Signal Pathway;Signal Transduction;single-cell RNA sequencing;skills;Specific qualifier value;synergism;targeted agent;Techniques;Testing;TGF Beta Signaling Pathway;Therapeutic;therapeutic development;therapy resistant;Time;Training;Transforming Growth Factor beta;treatment response;tumor;tumor microenvironment;Variant;Work

PROJECT_TITLE: Regulation and targeting of tumor cell states and plasticity in pancreatic cancer

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Emerging Infectious Diseases;Genetics;Immunization;Immunotherapy;Infectious Diseases;Lung;Nanotechnology;Orphan Drug;Prevention;Rare Diseases;Tuberculosis;Tuberculosis Vaccine;Vaccine Related

ORG_CITY: CHICAGO

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative Tuberculosis claimed 1.5 million lives across the world in 2018. With the rise of multi-drug resistant strains and lack of an effective vaccine for the adult population, tuberculosis remains an important public health concern. In this proposal, we aim to investigate lipid-based memory immune response and its potential role in protection in tuberculosis infection.

PI_NAMEs: MORGUN, EVA  (contact)

PROGRAM_OFFICER_NAME: MENDEZ, SUSANA

PROJECT_TERMS: Adoptive Transfer;Adult;Affect;Animal Model;anti-PD-1;anti-PD1 antibodies;Antibiotics;Antibody Formation;Antigen Presentation;Antigen-Presenting Cells;antigen-specific T cells;Antigens;Attenuated Vaccines;B cell differentiation;B-Lymphocytes;Bacteria;BCG Live;BCL1 Oncogene;BCL6 gene;Behavior;Cause of Death;CD1 Antigens;cell behavior;Cell Physiology;Cell Wall;Cells;Collaborations;CRISPR/Cas technology;cytokine;Data;Development;engineered T cells;Engineering;Epidemic;Exhibits;experience;experimental study;Family;Gene Expression Profile;Genetic Polymorphism;genetic signature;Helper-Inducer T-Lymphocyte;HIV Seropositivity;Human;Immune response;Immunize;Immunocompromised Host;Immunologic Memory;in vivo;Individual;Infection;inhibiting antibody;knock-down;Lipids;Marketing;Memory;MHC Class I Genes;Molecular;mouse model;Multi-Drug Resistance;Multiple drug resistant Mycobacteria Tuberculosis;Mus;mycobacterial;Mycobacterium bovis;Mycobacterium tuberculosis;Mycolic Acid;nanoparticle;Patients;Pattern;Peptides;Phase;Phenotype;Play;Population;prevent;Production;programmed cell death protein 1;Proteins;Public Health;receptor;Reproducibility;Research;resistant strain;response;Role;Schools;single cell sequencing;Sorting;Structure of germinal center of lymph node;Subunit Vaccines;Surface;T cell differentiation;T memory cell;T-Cell Activation;T-Cell Receptor;T-Lymphocyte;Testing;transcription factor;transcriptome;transcriptome sequencing;Transgenic Mice;Tuberculosis;tuberculosis immunity;Tuberculosis Vaccines;Vaccinated;Vaccination;vaccine candidate;vaccine efficacy;vaccine strategy;Vaccines;Virulent;Work

PROJECT_TITLE: Role of molecular drivers in memory group 1 CD1-restricted T cell differentiation and Mycobacterium tuberculosis infection

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F07-U(20)L]


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Chronic Pain;Digestive Diseases;Neurosciences;Pain Research

ORG_CITY: NEW YORK

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: NEW YORK UNIVERSITY

ORG_STATE: NY

PHR: PROJECT NARRATIVE  Irritable bowel syndrome (IBS) is a prevalent disorder characterized by visceral (e.g., abdominal) pain and disordered motility (e.g., constipation and/or diarrhea) for which there are limited effective treatments. Serotonin (5-HT) in the gastrointestinal tract is thought to play a role in these symptoms; most 5-HT is produced in the intestinal epithelium, but it is unknown how 5-HT released from the epithelium influences surrounding nerves to initiate visceral pain and/or gut motility. The proposed experiments will investigate how decreasing or increasing epithelial 5-HT availability impacts visceral pain and gut motility, which will help to determine potential new epithelial-restricted targets for IBS treatment.

PI_NAMEs: NAJJAR, SARAH  (contact)

PROGRAM_OFFICER_NAME: DENSMORE, CHRISTINE L

PROJECT_TERMS: Abdomen;Ablation;Adult;Adverse effects;Afferent Neurons;Anabolism;behavior measurement;Biological Assay;Cell secretion;Central Nervous System;Chemicals;Child;Childhood;Colon;colorectal distension;Communication;Constipation;cost;Cre driver;Data;Diarrhea;Disease;effective therapy;Enteral;Enteric Nervous System;Enterochromaffin Cells;Enzymes;Epithelial Cells;Epithelium;experimental study;Functional disorder;gastrointestinal;gastrointestinal epithelium;Gastrointestinal Motility;Gastrointestinal tract structure;Gastrointestinal Transit;improved;in vivo;Intervention;intervention effect;intestinal epithelium;Irritable Bowel Syndrome;Location;Measurement;mechanical stimulus;Mediating;Migrating Myoelectric Complex;Morbidity - disease rate;Motility;motility disorder;Motor;Mucous Membrane;Mus;Nerve;Neurons;Nociception;novel;optogenetics;Pain;paracrine;Persons;pharmacologic;Pharmacology;Physiological;Play;Reflex action;Regulation;Research;response;reuptake;Role;Selective Serotonin Reuptake Inhibitor;sensor;Sensory;Serotonin;serotonin receptor;Signal Transduction;Site;spatiotemporal;Spinal;Spinal Cord;Symptoms;Techniques;Testing;tool;Transgenic Mice;transmission process;Tryptophan 5-monooxygenase;Visceral;Visceral pain

PROJECT_TITLE: The role of mucosal serotonin in visceral nociception and gut motility


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

PHR: Project Narrative The incidence of heart failure is increasing and deadly with 50% of patients dying within 5 years of diagnosis. I propose to test a novel hypothesis that excessive carbohydrate modification of heart proteins (O-GlcNAcylation) activates a powerful pro-growth pathway (YAP) to cause heart failure. If affirmed, this hypothesis may serve as a basis for new and improved heart failure therapies.

PI_NAMEs: UMAPATHI, MAHAA  (contact)

PROGRAM_OFFICER_NAME: WANG, WAYNE C

PROJECT_TERMS: Accounting;Address;American;Animals;aorta constriction;Area;Arrhythmia;Award;Bioinformatics;Biological Assay;Biology;Carbohydrates;Cardiac;Cardiac health;Cardiac Myocytes;Cardiomyopathies;Cardiovascular system;career development;Cells;Chronic;Data;Depressed mood;Development;Development Plans;Diagnosis;Disease;Elements;Enzymes;Evaluation;Exhibits;experience;Exposure to;Gene Expression;Genes;Genetic;Genetic Models;Genetic Transcription;Glycobiology;Goals;Grant;Growth;Health;Heart;Heart Diseases;Heart failure;heart function;Heart Hypertrophy;Hospitalization;Human;Hypertrophy;improved;in vivo;Incidence;inhibitor;Investigation;Knock-out;Knowledge;Leadership;life span;Malignant Neoplasms;Mass Spectrum Analysis;Measures;Mediating;Mentors;Metabolism;Modification;mouse model;Mus;Muscle Cells;Myocardial;Myocardium;neonatal mice;novel;novel therapeutics;O-GlcNAc transferase;Operative Surgical Procedures;overexpression;Pathologic;Pathway interactions;Patients;peptide O-linked N-acetylglucosamine-beta-N-acetylglucosaminidase;Persons;Play;Positioning Attribute;Post-Translational Protein Processing;premature;Prevalence;prevent;programs;Protein Inhibition;Proteins;Publications;Publishing;repaired;Reporter;research and development;Research Personnel;response;Role;Serine;sham surgery;Signal Transduction;Signaling Protein;Site;skill acquisition;skills;Stress;System;targeted treatment;Techniques;Testing;Threonine;Training;transcription factor;Transgenic Mice;Transgenic Organisms;Translations;Treatment Failure;Ventricular;Verteporfin;Writing

PROJECT_TITLE: O-GlcNAcylation and YAP: Defining a novel pathway in heart failure

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(MA)]


NIH_SPENDING_CATS: Autoimmune Disease;Biomedical Imaging;Clinical Research;Crohn's Disease;Digestive Diseases;Inflammatory Bowel Disease;Osteoporosis;Pediatric;Prevention

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: Project Narrative Children with Crohn’s disease (CD) often have low bone mineral density (BMD) and altered bone structure, resulting in increased skeletal fragility and increased risk of fracture. The goals of this project are to examine adolescents with newly-diagnosed CD at baseline and one year later to evaluate the impact of CD inflammatory activity on bone marrow fat, BMD, bone turnover markers, and to correlate with peripheral blood immune parameters. This project has the potential to improve clinical care with new screening tools (i.e., magnetic resonance imaging) to identify patients at the highest risk for bone fragility, ideally prior to fracture; investigate novel measures of CD activity (i.e., bone turnover markers and immune cell and molecular signatures); and provide insights into potential new therapeutic targets.

PI_NAMEs: GORDON, REBECCA JUDITH (contact)

PROGRAM_OFFICER_NAME: SERRANO, KATRINA JANE

PROJECT_TERMS: Acceleration;Address;Adipocytes;Adolescence;Adolescent;adolescent patient;Adult;Anorexia Nervosa;Biomechanics;Body Composition;bone;Bone Density;bone fragility;bone geometry;bone health;Bone Marrow;bone mass;Bone Resorption;Bone structure;bone turnover;Boston;career;Case/Control Studies;Cells;Child;Childhood;Chronic;Clinical;clinical care;clinical investigation;clinically relevant;Crohn's disease;Data;Diagnosis;Disease;Dual-Energy X-Ray Absorptiometry;experience;Failure;Fatty acid glycerol esters;Fracture;fracture risk;Functional disorder;Goals;hands on research;Health;Hematopoietic;high risk;Hormonal;Hormonal Change;Imaging Techniques;Immune;Immune system;improved;Inflammatory;Inflammatory Bowel Diseases;insight;Knee;Knowledge;lean body mass;lifetime risk;Lipids;Location;Magnetic Resonance Imaging;Magnetic Resonance Spectroscopy;Marrow;Measures;Mediating;medical schools;Mentored Patient-Oriented Research Career Development Award;Mentors;Mesenchymal Stem Cells;Metabolism;Minerals;Molecular;Molecular Profiling;new therapeutic target;Newly Diagnosed;novel;Obesity;Osteoblasts;Osteogenesis;osteoimmunology;Osteoporosis;Patients;Pediatric Hospitals;pediatric patients;Peripheral;peripheral blood;Phenotype;Physicians;Population;premature;Preventive;prospective;Red Marrow;Research Methodology;Research Personnel;Scientist;Screening procedure;skeletal;Skeletal Development;skills;supportive environment;symposium;tool;Translational Research;treatment effect;X-Ray Computed Tomography;Yellow Marrow;Youth

PROJECT_TITLE: Skeletal Health and Bone Marrow Composition in Adolescents with Crohn’s Disease

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Bioengineering;Clinical Research;Complementary and Integrative Health;Natural Products;Prevention

ORG_CITY: PORTLAND

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Project Narrative Health care research has extensively studied pathogenesis or disease progression, but little is known about the complementary process of salutogenesis, or health restoration. This project will examine biochemical and functional changes associated with the reversal of age-related cognitive decline in mice, as a result of treatment with exercise and/or a botanical extract. Results will be used to design a computational model for future application to the study of multiple interventions on multiple body systems in animal or human studies.

PI_NAMEs: CHAMBERLIN, STEVEN  (contact)

PROGRAM_OFFICER_NAME: HORGUSLUOGLU, EMRIN U

PROJECT_TERMS: 8-hydroxy-2'-deoxyguanosine;Affect;Age;age related;Age-associated memory impairment;aged;Aging;animal old age;animal tissue;Animals;Attenuated;Behavioral;Biochemical;Blood;Body System;Botanicals;C-reactive protein;career;Cognition;Cognitive;cognitive change;cognitive enhancement;cognitive function;cognitive task;Complementary Health;Computer Models;Control Groups;Data;deep learning model;design;Development;Disease;Disease Progression;drinking water;dynamic system;Exercise;experience;experimental study;Female;Future;Genes;global health;Goals;Gotu kola;Graph;Health;Health Care Research;health data;Health Promotion;Health Status;Hippocampus;Human;Impaired cognition;improved;Individual;Inflammation;Inflammatory;insight;Integrative Medicine;interest;Intervention;Laboratories;Learning;male;Measurement;Measures;Mediating;Memory;metabolomics;Methodology;Methods;model building;model generalizability;model organism;Modeling;Molecular;molecular domain;Molecular Profiling;morris water maze;mouse model;Mus;Musculoskeletal;network models;old mice;Organ;Organism;Outcome;Oxidative Stress;Pathogenesis;Pathway interactions;Personal Satisfaction;Process;programs;promote resilience;Randomized;Research;response;restoration;Running;sex;System;Systems Biology;Testing;Therapeutic Intervention;Tissues;Training;transcriptomics;Water;whole health;Whole Organism

PROJECT_TITLE: Network models to capture multiple outcomes resulting from multi-component, salutogenic interventions


ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Narrative Although the importance of a diverse biomedical science workforce is widely appreciated, individuals from under-represented minority groups continue to comprise a disproportionately small percentage of biomedical researchers in this country. Inspiring undergraduate science teachers can reverse this pattern, but too few scientists are trained as teachers, and even fewer are attuned to the needs of diverse student populations. By combining mentored postdoctoral research at The University of Pennsylvania with training in pedagogy and mentored teaching experiences at partnering minority-serving institutions, the PennPORT IRACDA program trains outstanding researchers and teachers and enhances educational opportunities for students at partner institutions.

PI_NAMEs: BURKHARDT, JANIS K. (contact)

PROGRAM_OFFICER_NAME: NELSON, SHAKIRA M

PROJECT_TERMS: Address;Area;Behavioral;Biomedical Research;broadening participation research;career;community college;County;Delaware;Education;Educational process of instructing;Environment;Exposure to;Faculty;faculty research;Funding;Goals;Institution;Leadership;Learning;Mentors;Mentorship;Minority-Serving Institution;National Institute of General Medical Sciences;Outcome;pedagogical content;Pennsylvania;Population;Positioning Attribute;Postdoctoral Fellow;programs;Qualifying;Research;Research Personnel;Research Training;role model;Schools;Science;science education;Science, Technology, Engineering and Mathematics Education;Scientist;skills;STEM field;Students;success;teacher;Teacher Professional Development;Training;Training Programs;undergraduate student;Underrepresented Students;Universities

PROJECT_TITLE: IRACDA at the University of Pennsylvania: Penn Postdoctoral Opportunities in Research and Teaching (PennPORT).

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - D[TWD-D]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Aging;Anxiety Disorders;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Depression;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Precision Medicine;Serious Mental Illness

ORG_CITY: PITTSBURGH

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: This K01 application proposes the development and testing of an interpretable, neurobiologically-inspired integration scheme for multimodal neuroimaging measures to investigate antidepressant treatment outcome in late-life depression (LLD). Training in 1) the neurobiology, clinical manifestations, and treatment of LLD, 2) diffusion-weighted imaging processing and analysis, 3) advanced methods, 4) human subjects, study design, and data collection will enable the applicant to complete the proposed research and progress to an independent investigator focused on investigating the neurobiology of late life anxiety and mood disorders through improved integration of multimodal neuroimaging measures. The goal of this proposal is to integrate complementary network measures from structural and functional MRI with clinical measures to generate biologically relevant features that can improve prediction of treatment outcome in LLD.

PI_NAMEs: GERLACH, ANDREW ROBERT (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: Affect;Age;Algorithms;anti-depressive agents;Anxiety Disorders;Biological Markers;Brain;career;Clinical;clinical predictors;clinical translation;Cognitive;collaborative environment;computational neuroscience;computer framework;Data;Data Collection;Depressed mood;depressive symptoms;Development;Diffusion Magnetic Resonance Imaging;Disease remission;Doctor of Philosophy;Engineering;executive function;Functional disorder;Functional Magnetic Resonance Imaging;geriatric depression;Goals;gray matter;Health;high dimensionality;human subject;Image;image processing;image registration;Impairment;improved;Individual;interest;K-Series Research Career Programs;Knowledge;late life;late-life anxiety;machine learning model;Magnetic Resonance Imaging;Measurement;Measures;Mediating;Mediator;Mental Depression;Methods;Modality;Modeling;Montgomery and Asberg depression rating scale;Mood Disorders;multimodal data;multimodal neuroimaging;multimodality;National Institute of Mental Health;Nature;neural circuit;neurobiological mechanism;Neurobiology;Nuclear;Outcome;overtreatment;Participant;Pathway interactions;Performance;Physics;Play;Positioning Attribute;Prediction of Response to Therapy;predictive modeling;primary outcome;Prognosis;Psychiatry;Radiology Specialty;recruit;Reproducibility;Research;Research Design;Research Personnel;Resolution;response;Rest;Risk;Role;Scanning;Scheme;Science;Scientist;Severities;Specificity;statistics;Structure;Testing;tool;Training;Treatment outcome;Treatment Protocols;treatment response;Universities;white matter;white matter change

PROJECT_TITLE: Individual Multimodal Pathway Statistics for Predicting Treatment Response in Late-life Depression

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


ADMINISTERING_IC: DA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

ORG_CITY: CHARLESTON

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: PROJECT NARRATIVE The MUSC SCORE coalesces investigators across different disciplines working closely together to explore sex and gender differences in substance use disorders and the relationship between stress and drug use. This project catalyzes further growth of interdisciplinary sex and gender-based research on the MUSC campus and creates strategic partnerships to enhance the translation and dissemination of SCORE findings and other relevant research to improve women’s health.

PI_NAMEs: GRAY, KEVIN M;MCRAE-CLARK, AIMEE L (contact)

PROGRAM_OFFICER_NAME: NAIR, SUNILA GOPI

PROJECT_TERMS: Acute;addiction;Address;Area;Behavioral;biological sex;Cannabis;career;Centers of Research Excellence;Clinical;Clinical Research;Collaborations;Communities;Data;Dedications;Discipline;Diverse Workforce;Drug usage;Education and Outreach;emerging adult;Ensure;Faculty;Fostering;Funding;Gender;gender difference;Goals;Growth;Health;improved;innovation;insight;Institution;Interdisciplinary Study;Investments;Leadership;life span;marijuana use;marijuana use disorder;Mentors;multidisciplinary;neural circuit;novel therapeutic intervention;older adult;Outcome;Output;Pilot Projects;Population;Postpartum Women;Productivity;programs;Public Health;Relapse;Research;Research Institute;Research Personnel;Research Project Grants;Research Training;Resources;Science;SCTR gene;Services;sex;Sex Differences;sex disparity;skills;South Carolina;Specialized Center;Strategic Planning;Stress;substance use;Substance Use Disorder;success;Therapeutic;therapy development;Training;training opportunity;translational approach;Translational Research;translational research program;Translations;United States National Institutes of Health;Universities;Vision;Woman;Women's Health;Work

PROJECT_TITLE: MUSC Specialized Center of Research Excellence on Sex Differences Renewal 2022

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-EMS-A(70)R]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cannabidiol Research;Cannabinoid Research;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Drug Abuse (NIDA only);Endocannabinoid System Research;Mental Health;Natural Products;Substance Misuse;Women's Health Research

PHR: PROJECT NARRATIVE The interface between cannabis use and stress is a particularly important focus for sex differences research in emerging adults. Given the dynamics at play in this critical stage when cannabis use is most prevalent, developmentally informed research is needed to guide tailored clinical interventions. We propose a study applying rigorous and innovative methods to elucidate sex differences in the nexus of cannabis use and stress among emerging adults with cannabis use disorder to guide the development of tailored treatments.

PI_NAMEs: GRAY, KEVIN M (contact)

PROJECT_TERMS: Abstinence;Acute;Address;Adult;Adult women;Affect;Age;age group;Attenuated;behavior influence;Behavioral;Binding;Biological;biological adaptation to stress;Biological Assay;Biological Markers;Blood;Brain;Cannabidiol;Cannabis;cannabis withdrawal;Centers of Research Excellence;Chronic;Clinical;Clinical Management;Cognitive;Collection;coping;design;Development;Developmental Process;Dose;Double-Blind Method;Ecological momentary assessment;emerging adult;emerging adulthood;Emotions;endocannabinoid signaling;Endocannabinoids;endogenous cannabinoid system;Estradiol;Exhibits;exogenous cannabinoid;experimental study;Exposure to;Female;Future;General Population;Human;Impairment;individualized medicine;innovation;Intervention;Laboratories;Laboratory Procedures;life span;male;marijuana use;marijuana use disorder;marijuana user;Measures;men;Methods;Monitor;neurodevelopment;Outcome;Participant;Patient Self-Report;Pattern;Physiological;Physiology;Placebo Effect;placebo group;Placebos;Play;pre-clinical;Pre-Clinical Model;receptor;Relapse;Reporting;reproductive hormone;Research;Role;Running;Sampling;Severities;sex;Sex Differences;Specialized Center;Standardization;Stress;Stress and Coping;stress management;stress reactivity;stress reduction;stress resilience;Symptoms;System;Systems Development;Testing;Tetrahydrocannabinol;therapy development;Time;Withdrawal;Withdrawal Symptom;Woman;women versus men;Work

PROJECT_TITLE: Sex Differences in the Interface between Cannabis Use and Stress among Emerging Adults

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-EMS-A]


NIH_SPENDING_CATS: Autoimmune Disease;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Pediatric;Physical Activity

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: PROJECT NARRATIVE Adaptive Motif-Based Control (AMBC): A Fundamentally New Approach to Automated Treatment Optimization for Type 1 Diabetes This application comes from the developers of the UVA Automated Insulin Delivery (AID) System, which in 2012 was the first wearable artificial pancreas running on a smart phone, and in 2017 was built in Tandem’s t:slim X2 insulin pump to become Control-IQ – an AID system now used by over 270,000 people with diabetes worldwide. After this successful clinical translation, our academic mandate now is to open new horizons, design and test a new class of AID algorithms –Adaptive Motif-Based Control (AMBC)– which uses innovative adaptation-to-profile process to modulate the UVA-AID individual parameters for a person, by learning from this person’s CGM and insulin delivery patterns, and from the patterns of others stored in population databases; thus, unlike any other AID algorithm, the AMBC will use both a person’s own history and the history of others, to forecast and adapt to metabolic disturbances. The AMBC is expected to (i) be superior to current state-of-the-art AID systems in terms of glycemic outcomes and technology acceptance, and (ii) enable the transition from hybrid to full closed loop.

PI_NAMEs: BROWN, SUE A;KOVATCHEV, BORIS P (contact)

PROGRAM_OFFICER_NAME: ARREAZA-RUBIN, GUILLERMO

PROJECT_TERMS: Address;Adult;advanced system;Algorithms;Area Under Curve;Artificial Intelligence;Artificial Pancreas;Cellular Phone;Child;Classification;Clinical;clinical practice;clinical translation;Clinical Trials;Code;Color;Continuous Glucose Monitor;control trial;Cross-Over Trials;Crossover Design;Data;data library;Data Science;data space;Databases;deep neural network;design;Development;Diabetes Mellitus;efficacy evaluation;Enrollment;Europe;European;Exercise;experience;Glucose;glycemic control;Goals;Health;Health Personnel;Hour;Hybrids;Hyperglycemia;Hypoglycemia;improved;Incidence;Individual;Inferior;Injections;innovation;Insulin;Insulin Infusion Systems;Insulin-Dependent Diabetes Mellitus;Learning;Libraries;Measures;Medicine;Metabolic;Methods;Modality;Monitor;New England;new technology;next generation;Non-Insulin-Dependent Diabetes Mellitus;novel;novel strategies;Outcome;Participant;Patient Education;Pattern;Pattern Recognition;Persons;Physical activity;Pilot Projects;Population;Population Database;Process;process optimization;Proliferating;Property;Protocols documentation;Publishing;Randomized;Recording of previous events;Running;Structure;subcutaneous;System;Technology;Testing;Text;Time;tool;treatment optimization;trial comparing;trial enrollment;virtual;wearable device

PROJECT_TITLE: ADAPTIVE MOTIF-BASED CONTROL (AMBC): A FUNDAMENTALLY NEW APPROACH TO AUTOMATED TREATMENT OPTIMIZATION FOR TYPE 1 DIABETES

STUDY_SECTION: CIDH

STUDY_SECTION_NAME: Clinical Informatics and Digital Health Study Section[CIDH]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cannabinoid Research;Clinical Research;Drug Abuse (NIDA only);Maternal Health;Maternal Morbidity and Mortality;Mental Health;Prevention;Substance Misuse;Women's Health Research

PHR: PROJECT NARRATIVE While most women who use cannabis will reduce their cannabis use during pregnancy, almost all women will return to cannabis use postpartum. Stress and progesterone may play important roles in the return to postpartum cannabis use but longitudinal investigations are needed to examine the relationships between stress, progesterone and return to cannabis use in postpartum women. The proposed study will help to inform the develop of gender-specific, targeted interventions that prevent postpartum return to cannabis use and improve women’s health.

PI_NAMEs: GUILLE, CONSTANCE  (contact)

PROJECT_TERMS: Abstinence;Affect;Anxiety;Attenuated;Behavior;Biological Testing;Birth;Cannabis;Centers of Research Excellence;Child;cigarette smoking;Cocaine;Conceptions;craving;Data;Development;diaries;drug reward;drug seeking behavior;Ecological momentary assessment;Gender;Goals;Health;improved;Individual;Infant;Interruption;Intervention;Investigation;Link;Maintenance;marijuana use;marijuana use disorder;marijuana use in pregnancy;marijuana user;Maternal Health;Measures;Mediating;Mental Depression;Methodology;Monitor;Moods;Nature;neonatal health;Outcome;Participant;Pattern;Perinatal;perinatal period;perinatal women;Pike fish;Play;Post-Traumatic Stress Disorders;Postpartum Period;Postpartum Women;Pregnancy;Pregnant Women;prepregnancy;prevent;preventive intervention;Progesterone;Prospective Studies;Relapse;Reporting;return to use;Risk;Role;Salivary;sex;Sex Differences;Sleep;Sleep Deprivation;sleep quality;Specialized Center;Stress;Stressful Event;stressor;substance use;targeted treatment;therapy development;Time;Tobacco;Tobacco use;Woman;women versus men;Women's Health;Women's study;Work

PROJECT_TITLE: The Impact of Stress and Craving on Return to Postpartum Cannabis Use


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Genetics;HIV/AIDS;Infectious Diseases

ORG_NAME: ROCKEFELLER UNIVERSITY

PHR: To achieve optimal replication, HIV-1 encodes viral ‘accessory” proteins to that manipulate the host cell. Understanding the mechanisms by which host proteins targeted by the accessory protein Vpr repress HIV-1 replication, and how and why viral proteins such as Vpr deplete particular host proteins will provide new insights into the regulation of HIV-1 gene expression, regulation of cell cycle and regulation of innate immunity. This understanding may present new targets for eliminating reservoirs of HIV-1.

PI_NAMEs: BIENIASZ, PAUL D. (contact)

PROGRAM_OFFICER_NAME: LAWRENCE, DIANE M

PROJECT_TERMS: African Green Monkey;Biological;Cell Cycle;Cell Cycle Arrest;Cell Cycle Progression;Cell Cycle Regulation;Cell Death;Cell Death Induction;cell type;Cells;Chromatin;Chromosomes;Cis-Acting Sequence;Clustered Regularly Interspaced Short Palindromic Repeats;cofactor;Complex;Cullin Proteins;Dependence;DNA;DNA Damage;Enhancers;fascinate;Gene Expression;gene repression;HIV;HIV-1;Human;Hybrids;Innate Immune Response;insight;Integration Host Factors;integration site;Investigation;knock-down;Lentivirus;M cell;Macaca mulatta;Macrophage;Maps;Mediating;Mediator;Messenger RNA;Methods;Mitotic;Molecular;mutant;Natural Immunity;novel therapeutic intervention;Nuclear;prevent;Primates;promoter;Proteins;Proteomics;Regulation;Reporter;Reporting;Repression;response;RNA Interference;Role;screening;sensor;Series;SIV;ubiquitin-protein ligase;vector;Viral;viral DNA;Viral Genes;Viral Proteins;Virus;Virus Integration;Yeasts

PROJECT_TITLE: Host protein targets of HIV-1 Vpr in gene expression, cell cycle and innate immunity

STUDY_SECTION: HVCD

STUDY_SECTION_NAME: HIV Molecular Virology, Cell Biology, and Drug Development Study Section[HVCD]


NIH_SPENDING_CATS: Cancer;Clinical Research;Genetics;Immunotherapy;Orphan Drug;Ovarian Cancer;Rare Diseases;Women's Health Research

ORG_CITY: SCOTTSDALE

ORG_NAME: MAYO CLINIC ARIZONA

ORG_STATE: AZ

PHR: PROJECT NARRATIVE The immune response is highly active in ovarian cancer, but ovarian tumors do not respond well to immune checkpoint blockade (ICB). We propose to investigate whether inhibition of DNA damage repair by blocking the function of the protein phosphatase 4 complex during chemotherapy will increase immunogenicity in ovarian cancer and enhance response to ICB. Ultimately, such knowledge has the potential to inform the development of new therapies benefiting many types of cancer.

PI_NAMEs: CURTIS, MARION  (contact)

PROGRAM_OFFICER_NAME: LIU, YIN

PROJECT_TERMS: anti-tumor immune response;Antigen Presentation;Antigen Presentation Pathway;Binding;cancer cell;Cancer cell line;Cancer Etiology;cancer therapy;cancer type;cancer/testis antigen;Carboplatin;CD8-Positive T-Lymphocytes;cell motility;Characteristics;checkpoint therapy;Chemoresistance;chemotherapy;Complex;crosslink;cytotoxicity;Data;Death Rate;Development;DNA;DNA Adducts;DNA Damage;DNA Repair;drug resistance development;Effectiveness;experimental study;Fatality rate;Frequencies;Gamma-H2AX;Genomic Instability;Human;immune checkpoint blockade;Immune checkpoint inhibitor;Immune response;Immuno-Chemotherapy;Immunocompetent;immunogenic cell death;immunogenicity;Immunotherapy;improved;improved outcome;In Vitro;in vivo;Individual;Inflammatory;inhibitor;innovation;knock-down;Knock-out;Knowledge;Malignant Female Reproductive System Neoplasm;Malignant neoplasm of ovary;Malignant Neoplasms;Mediating;micronucleus;mouse model;Natural Killer Cells;new therapeutic target;novel therapeutic intervention;novel therapeutics;Organoids;ovarian neoplasm;overexpression;p53-binding protein 1;Phenotype;phosphatase inhibitor;phosphoproteomics;Phosphoric Monoester Hydrolases;Platinum;Play;Process;programmed cell death protein 1;Protein Dephosphorylation;protein function;Protein phosphatase;Proteins;Reaction;recruit;repaired;Research;Resolution;response;Role;Serous;Signal Pathway;Signal Transduction;STAT1 gene;synergism;T cell infiltration;T-Lymphocyte;Testing;Therapeutic;Translating;tumor;tumor growth;Tumor Immunity;tumor microenvironment;Tumor-Infiltrating Lymphocytes;women's outcomes

PROJECT_TITLE: Targeting PP4 to improve ovarian cancer response to immunotherapy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-TIR-W(01)Q]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cannabinoid Research;Clinical Research;Dementia;Drug Abuse (NIDA only);Mental Health;Neurodegenerative;Neurosciences;Substance Misuse;Women's Health Research

PHR: PROJECT NARRATIVE Cannabis is the most frequently used illicit substance by older adults, and its use among persons ages 50+ is rising. Little is known about the potential harms of cannabis use in this population such as its impact on cognitive decline and risk for Alzheimer’s disease and related dementias, and whether sex differences in stress and hormones influence these risks. We therefore propose to study regular cannabis-using older men and women to answer these questions to inform public health messaging regarding cannabis use and to identify potential clinical interventions for older adults.

PI_NAMEs: MCRAE-CLARK, AIMEE L (contact)

PROJECT_TERMS: acute stress;Adolescent and Young Adult;Adult;adverse childhood events;Adverse effects;Affect;Age;age effect;Age-associated memory impairment;Aging;Alzheimer's disease related dementia;Alzheimer's disease risk;Behavioral;biological adaptation to stress;Biological Markers;Cannabis;cannabis craving;Centers of Research Excellence;Chronic;Chronic stress;Clinical;Clinical Research;Cognition;Cognitive aging;cognitive function;Coupled;Cross-Sectional Studies;Data;dementia risk;Disparity;Ecological momentary assessment;emerging adult;Ensure;Episodic memory;Estradiol;Exposure to;Goals;Health Resources;Hormonal Change;Hormones;Impaired cognition;Individual;Institution;Intervention;late life;Literature;Longitudinal Studies;Maintenance;marijuana use;marijuana user;Measures;Mediating;Memory impairment;men;mouse model;Neuropsychological Tests;older adult;older men;older women;Ovarian hormone;Persons;Pilot Projects;Plasma;Population;Population Heterogeneity;preclinical study;Process;Progesterone;Public Health;Reproductive History;Research;Risk;Role;Rural Health;sex;Sex Differences;Specialized Center;Stress;stress reduction;telehealth;Testing;Theoretical model;Woman;young adult

PROJECT_TITLE: Sex Differences in Risk of Cognitive Decline in Older Cannabis Users


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Cannabidiol Research;Cannabinoid Research;Complementary and Integrative Health;Drug Abuse (NIDA only);Natural Products;Neurosciences;Pediatric;Substance Misuse;Therapeutic Cannabinoid Research;Women's Health Research

PHR: PROJECT NARRATIVE Legalization of cannabis products for recreational use has increased rates of cannabis use and Cannabis Use Disorder across multiple vulnerable groups, including adolescents/young adults, pregnant women, and older adults. Despite legalization, the neurobiological impacts of acute and chronic cannabis use, and how they are affected by sex and age, largely remain uninvestigated. In this proposal, and the associated Clinical Projects 1- 3, we will investigate how the active components of cannabis impact learning and memory, relapse behavior, and brain function at the molecular level in vulnerable populations.

PI_NAMEs: REICHEL, CARMELA M (contact)

PROJECT_TERMS: Abstinence;abuse liability;Acute;Adolescence;Adolescent;Adult;Affect;Age;age difference;age group;aged;Behavior;Behavior assessment;behavior test;Behavioral;Binding;Biological;Birth;Brain;Breeding;Cannabidiol;Cannabis;Centers of Research Excellence;Chronic;Clinical;Cocaine;Cognitive;cognitive function;Consumption;Cues;Development;drug of abuse;electronic cigarette use;emerging adult;emotional distress;endocannabinoid signaling;Euthanasia;Exhibits;Exposure to;Female;Female Adolescents;Funding;Gene Expression;General Population;Goals;Harvest;Heroin;Hippocampus;Human;Intake;Investigation;Knowledge;Learning;Legal;Legal Status;life span;lipidomics;Lipids;Longitudinal cohort;male;Male Adolescents;marijuana legalization;marijuana use;marijuana use disorder;Maternal Behavior;Measures;Medical;Medical Marijuana;Memory;Modeling;Molecular;Mothers;Neurobiology;Nose;older adult;Outcome;Outcome Assessment;Ovarian hormone;Pattern;Pharmaceutical Preparations;Plasma;postnatal;Postpartum Period;pre-clinical;Predisposition;Prefrontal Cortex;Pregnancy;pregnant;Pregnant Women;prepregnancy;Progesterone;Proteins;Protocols documentation;Rattus;Recreation;Relapse;Relaxation;Reporting;reproductive;response;RNA;Rodent Model;Role;Self Administration;sex;Sex Differences;Signal Transduction;spatial memory;Specialized Center;Stress;stress reactivity;Synaptic plasticity;Technology;Testing;Tetrahydrocannabinol;Time;Tissues;Transcend;vapor;Vulnerable Populations;young adult

PROJECT_TITLE: Sex differences in THC/CBD self-administration of vulnerable age groups throughout the life span


NIH_SPENDING_CATS: Drug Abuse (NIDA only);Substance Misuse;Women's Health Research

PHR: PROJECT NARRATIVE The Leadership Administrative Core (LAC) is the hub of the MUSC SCORE, serving as the central coordinating point for all SCORE activities. It influences each of the research projects and Center cores, and brings the various components together to form a cohesive, functioning unit. The LAC also oversees SCORE outreach, collaboration, and evaluation efforts.

PROJECT_TERMS: Accountability;Address;Biometry;Centers of Research Excellence;Clinical Research;Collaborations;Communication;dashboard;Data;Diverse Workforce;Ensure;Evaluation;Extramural Activities;Funding;Gender;gender difference;Goals;Human Resources;improved;Information Dissemination;Institution;Lead;Leadership;Medical;meetings;Modification;Monitor;Office of Administrative Management;operation;Outcome Assessment;outreach;Performance;Pilot Projects;Program Evaluation;programs;Research;Research Personnel;Research Project Grants;Resources;Scheme;sex;Sex Differences;South Carolina;Specialized Center;Substance Use Disorder;success;Training;Translational Research;Universities;Vertebral column

PROJECT_TITLE: MUSC SCORE Leadership Administrative Core


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: Canton

ORG_NAME: HARVARD PILGRIM HEALTH CARE, INC.

PHR: PROJECT NARRATIVE Choosing the wrong health insurance plan could put patients at risk for poor health and economic outcomes, especially for patients with a chronic disease like diabetes. This study will use health economic research methods to assess patient preferences for health plans and the relationship between enrollment in a preference-aligned health plan and health care outcomes. Future research will develop a decision aid based on study findings to help guide patients toward a health plan that will improve their outcomes.

PI_NAMEs: WRIGHT, DAVENE RENEE (contact)

PROGRAM_OFFICER_NAME: KARACA, ZEYNAL

PROJECT_TITLE: Optimizing Choice of Health Insurance For Diabetes (OrCHID)

STUDY_SECTION: HSVR

STUDY_SECTION_NAME: Healthcare Systems and Values Research[HSVR]


NIH_SPENDING_CATS: Behavioral and Social Science;Drug Abuse (NIDA only);Substance Misuse;Women's Health Research

PHR: PROJECT NARRATIVE The SCORE Career Enhancement Core (CEC) provides a formal, intensive program of mentored clinical and translational research training and career development activities to promote junior scholars in the area of sex- and gender-based clinical and translational research focused on the impact of stress on human health. Training scientists with an understanding of the role of sex and gender in the etiology and pathophysiology of specific disease states will allow for optimization of personalized approaches to diagnosis and treatment essential to improving the health of both men and women.

PI_NAMEs: BRADY, KATHLEEN T. (contact)

PROJECT_TERMS: Active Learning;Address;Appointment;Area;Awareness;base;Biometry;career;career development;Centers of Research Excellence;Clinical Research;Collaborations;Consultations;Data;Dedications;design;Development;Diagnosis;Disease;Diverse Workforce;early-career faculty;Elements;Ensure;Environment;Etiology;Evaluation;experience;Functional disorder;fundamental research;Future;Gender;gender difference;Goals;Good Clinical Practice;Grant;Health;Human;human subject protection;improved;Individual;Interdisciplinary Study;Judgment;Knowledge;learning progression;men;Mentors;Mentorship;personalized approach;Privacy;Process;Program Effectiveness;programs;Reporting;Reproducibility;Research;Research Design;Research Methodology;Research Personnel;Research Training;responsible research conduct;Role;Scientist;sex;sex as a biological variable;Sex Differences;skill acquisition;skills;sound;Specialized Center;Statistical Data Interpretation;Stress;Teacher Professional Development;Training;training opportunity;Training Programs;Translational Research;translational scientist;Woman;Women's Health;Work;Writing

PROJECT_TITLE: MUSC SCORE Career Enhancement Core


NIH_SPENDING_CATS: Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Substance Misuse;Women's Health Research

PHR: PROJECT NARRATIVE The Biostatistics Resource Core provides centralized support to the entire MUSC SCORE team of investigators and strives to promote synergy in terms of study design and analyses across projects and other shared resources. It also contributes to the career enhancement and dissemination missions of the MUSC SCORE.

PI_NAMEs: BAKER, NATHANIEL LEE (contact)

PROJECT_TERMS: Area;Biometry;Biostatistical Methods;Biostatistics Core;career;Centers of Research Excellence;Clinical;clinical development;Clinical Investigator;clinical practice;Clinical Research;Clinical Treatment;Clinical Trials;Collaborations;Communities;Consultations;Data;Data Analyses;data management;Data Storage and Retrieval;Databases;design;Development;Drug abuse;Drug usage;Education;Educational Activities;Educational workshop;Ensure;experience;Experimental Designs;Future;gender disparity;Goals;Knowledge;Leadership;lectures;Manuscripts;member;method development;Methodology;Methods;Mission;Monitor;novel;Pattern;Pilot Projects;pre-clinical;Preparation;Process;Productivity;programs;Publications;Quality Control;Recording of previous events;Reporting;Research;Research Design;Research Personnel;Research Project Grants;Research Support;Resource Sharing;Resources;Series;sex;Sex Differences;Specialized Center;Statistical Data Interpretation;Stress;Substance Use Disorder;synergism;Techniques;Training;Translating;Translational Research;translational scientist;Work

PROJECT_TITLE: MUSC SCORE Biostatistics Resource Core


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Suicide;Suicide Prevention

ORG_CITY: ORLANDO

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF CENTRAL FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE This multi-level, multi-component longitudinal, mixed-methods study incorporates an intersectional lens in the examination of how intersectional minority stress and Black sexual and gender minority (SGM)-specific protective factors affect active suicide ideation over time, day-to-day, and within specific contexts both within and between populations of Black SGM youth. Participants will include 625 Black SGM youth aged 13 to 26 who will complete an online survey every three months over an 18-month period to examine moderating effects of Black SGM-specific individual and community protective factors on theoretical pathways of suicide risk, including intersectional minority stress, over time, with a subset of 450 completing one of three burst daily diary surveys to identify proximal correlates of suicide risk, including protective factors, and a subset of 180 completing an individual interview to explore in-depth effects of contextual factors on suicide risk among Black SGM youth. This research will help address social injustices that characterize mental health disparities among Black SGM youth by identifying novel, modifiable Black SGM-specific individual and community protective factors, and effects of structural factors on the experience of intersectional minority stress and suicide risk, that will inform the development of a culturally relevant theory of suicide risk and future tailored, strengths-based suicide prevention interventions for this population.

PI_NAMEs: COOK, STEPHANIE HAZEL;MUEHLENKAMP, JENNIFER JO;TALIAFERRO, LINDSAY A (contact)

PROGRAM_OFFICER_NAME: MURPHY, ERIC ROUSSEAU

PROJECT_TERMS: Address;Affect;Age;age group;aged;Area;Bisexual;Black Populations;Black race;black subgroup;cisgender;climate zone;Communities;community engagement;community involvement;contextual factors;Data;Development;diaries;Discrimination;educational atmosphere;Ensure;experience;Feeling suicidal;Future;Gender Identity;gender minority community;gender minority group;gender minority youth;Glean;health disparity;Heterosexuals;Individual;Inequity;insight;Intervention;Interview;Laws;lens;Lesbian Gay Bisexual;Lesbian Gay Bisexual Transgender Queer;Longitudinal Studies;Marketing;Mediation;men;Mental Health;Methodology;Methods;minority stress;Modeling;Motivation;nonbinary;novel;Participant;Pathway interactions;Persons;Population Intervention;Predictive Factor;Process;protective factors;psychologic;Psychopathology;Qualitative Methods;racial identity;racism;Recommendation;recruit;Religion;Religiosity;Reporting;Research;Resistance;response;Risk;Risk Factors;rural residence;Sampling;Sexual and Gender Minorities;sexual identity;sexual minority group;sexual minority youth;social;social media;Social support;structural determinants;Subgroup;suicidal;suicidal behavior;suicidal risk;Suicide;Suicide attempt;Suicide prevention;suicide rate;Surveys;theories;Time;transgender;United States National Institutes of Health;Woman;Youth

PROJECT_TITLE: A Strengths-Based, Intersectional Approach to Suicide Prevention Among Black Sexual and Gender Minority Youth


ADMINISTERING_IC: HG

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PROJECT NARRATIVE Rapid advances in laboratory technology and digital healthcare have created a new discipline that uses genetic information to individualize patient care. The Vanderbilt Genomic Medicine (VGM) Training Program at Vanderbilt University Medical Center trains MD and PhD post-doctoral fellows to become knowledgeable with the science and practice of genomic medicine. The program teaches research design and analytic techniques with the ability to apply these methods in a clinical setting to advance patient care.

PI_NAMEs: COX, NANCY J;PETERSON, JOSEPH F. (contact);RODEN, DAN M

PROGRAM_OFFICER_NAME: COLLEY, HEATHER

PROJECT_TERMS: Genomic medicine;Training Programs

PROJECT_TITLE: VGM: Vanderbilt Genomic Medicine Training Program


NIH_SPENDING_CATS: Antimicrobial Resistance;Biotechnology;Clinical Research;Genetics;HIV/AIDS;Infectious Diseases;Prevention

ORG_CITY: Bern

ORG_COUNTRY: SWITZERLAND

ORG_FIPS: SZ

ORG_NAME: UNIVERSITAT BERN

PHR: NARRATIVE The emergence and spread of drug-resistant HIV is a major threat to ending the global HIV epidemic. HIV treatment programs across the world are transitioning to integrase strand transfer inhibitors. We propose establishing a global early HIV drug resistance detection system within the International epidemiology Databases to Evaluate AIDS (IeDEA) and the Antiretroviral Therapy Cohort Collaboration (ART-CC). In this study, we will develop a better understanding of how dolutegravir resistance emerges in different HIV subtypes and different clinical contexts, and how genotypic resistance affects phenotypic susceptibility to dolutegravir.

PI_NAMEs: EGGER, MATTHIAS  (contact)

PROGRAM_OFFICER_NAME: HUEBNER, ROBIN E

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Adolescent;Adult;advanced disease;Affect;Africa;Age;American;Anti-Retroviral Agents;antiretroviral therapy;Asia;Biological;Biological Assay;Biological Sciences;Canada;Caribbean region;Central America;Clinical;Clinical Data;clinical research site;cohort;Collaborations;Country;Data;data harmonization;Databases;detection platform;Development;Drug resistance;Early Diagnosis;Epidemic;Epidemiology;European;experience;Exposure to;Failure;France;Frequencies;Funding;Genes;Genetic;genome sequencing;Genotype;Geographic Locations;Germany;Goals;Guidelines;Health system;HIV;HIV drug resistance;HIV Infections;HIV-1;Individual;inhibitor;inhibitor therapy;Integrase;International;male;Modeling;Monitor;Mutation;nef Genes;Netherlands;next generation sequencing;novel;Pathway interactions;Patient Recruitments;Patients;Pattern;Persons;Pharmaceutical Preparations;Phase;Phenotype;pre-exposure prophylaxis;Predisposition;Prevalence;prospective;public health intervention;Recommendation;Recording of previous events;Recycling;Regimen;Resistance;resistance mutation;response;Rifampin;Risk Factors;Role;Sampling;sequencing platform;sex;Site;South Africa;South America;Spain;Specimen;Standardization;Switzerland;System;Testing;Time;treatment program;United States National Institutes of Health;Viral Genome;Viral Load result;Virus;whole genome;World Health Organization

PROJECT_TITLE: HIV-1 subtype, specific drug resistance in patients failing Dolutegravir-based 1st, 2nd or 3rd line regimens: the International epidemiological Databases to Evaluate AIDS (IeDEA)

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Immunotherapy

ORG_DEPT: BIOLOGY

ORG_NAME: HERBERT H. LEHMAN COLLEGE

PHR: PROJECT NARRATIVE Cancer ranks as the second leading cause of death in men and women of all age groups in the U.S., and currently 1 out of 4 death in the U.S. is due to cancer. The severe adverse effects due to many anti-cancer therapeutic strategies currently in use are associated with their undesired effects on healthy, non-cancer cells. This project, therefore, is directed toward understanding cellular and molecular mechanisms that will help develop a specific cancer therapy that only kills tumor cells.

PI_NAMEs: SAUANE, MOIRA  (contact)

PROGRAM_OFFICER_NAME: CUPIT, PAULINE

PROJECT_TERMS: activating transcription factor 4;Adverse effects;age group;Animal Model;anti-cancer;anti-cancer therapeutic;anti-tumor immune response;anticancer activity;Antineoplastic Agents;Apoptosis;Biochemical;Biological Assay;Biological Markers;cancer cell;cancer therapy;Cause of Death;cell growth regulation;Cell Proliferation;Cells;Cessation of life;Clinical;Collaborations;Complex;Data;Development;Down-Regulation;Drug Kinetics;efficacy study;Ensure;Eukaryotic Initiation Factor-2;experimental study;Genetically Engineered Mouse;genetically modified cells;Goals;Growth;Human;human cancer mouse model;Immune checkpoint inhibitor;immunogenicity;Immunology;In Vitro;in vivo;Induction of Apoptosis;inhibitor;Injections;Interleukin-24;Link;Lymphocyte Biology;Maintenance;Malignant - descriptor;Malignant Neoplasms;Mediating;medical schools;men;Modeling;Modernization;Molecular;mouse model;mutant;neoplastic cell;New York;Normal Cell;Nude Mice;Oncogenic;Phosphorylation;Physiological;Play;primary endpoint;programmed cell death ligand 1;Proteins;Regulation;research clinical testing;restoration;restraint;Role;Solid Neoplasm;T-Lymphocyte;Testing;therapeutic gene;Time;Toxic effect;Translation Initiation;Translational Repression;tumor;tumor growth;Tumor Immunity;tumor progression;Tumor Suppression;Universities;Up-Regulation;Woman;Work;Xenograft procedure

PROJECT_TITLE: Translation Initiation Inhibitor for Cancer Therapy


NIH_SPENDING_CATS: Cancer;Genetics;HIV/AIDS;Hematology;Infectious Diseases;Lymphatic Research;Lymphoma;Rare Diseases

ORG_CITY: DURHAM

ORG_DEPT: GENETICS

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE Epstein-Barr virus promotes lymphomas in the immune suppressed. These studies will characterize and exploit the underlying single cell heterogeneity in these tumors to develop new therapies.

PI_NAMEs: LUFTIG, MICAH A. (contact)

PROGRAM_OFFICER_NAME: READ-CONNOLE, ELIZABETH LEE

PROJECT_TERMS: Adult;African Burkitt's lymphoma;Age;Animal Model;B lymphocyte immortalization;B-Cell Lymphomas;B-Cell NonHodgkins Lymphoma;B-Lymphocytes;Behavior;Biological Markers;cell killing;Cell model;Cell Separation;Cells;Clinical Trials;Coupled;Cytotoxic T-Lymphocytes;Data;Development;DNA Damage;Epstein Barr Virus B cell lymphoma;epstein barr virus mediated immortalization;Epstein-Barr Virus Infections;Epstein-Barr Virus latency;Exhibits;experimental study;Failure;Frequencies;Ganciclovir;Gene Expression;Gene Expression Profile;gene product;Genetic;Goals;Growth;Herpesviridae;Heterogeneity;Histone Deacetylase;Histone Deacetylase Inhibitor;HIV Infections;Human;Human Herpesvirus 4;Immune;Immunosuppression;In Vitro;in vivo;Individual;infected B cell;Infection;innate immune sensing;large cell Diffuse non-Hodgkin's lymphoma;latent infection;Latent virus infection phase;lymphoblastoid cell line;Lymphoma;Lymphoma cell;Lymphomagenesis;Lytic;Lytic Virus;Mediating;Minor;Modeling;Molecular;Monitor;mouse model;neoplastic cell;Non-Hodgkin's Lymphoma;novel therapeutics;Oncogenic;Oncogenic Viruses;Organ Transplantation;Outcome;Pathogenesis;Phenotype;Phosphotransferases;Plasmablast;Population;Predisposition;programs;Proliferating;Protein Kinase;Regulation;Repression;Research;response;Rest;Role;sensor;single-cell RNA sequencing;success;T cell response;Testing;Therapeutic;Therapeutic Intervention;transforming virus;tumor;tumor heterogeneity;tumor progression;Tumor Tissue;tumorigenesis;Valganciclovir;Viral;Viral Proteins;virtual;Virus;Work;Xenograft Model

PROJECT_TITLE: Defining and exploiting EBV-infected cell heterogeneity in non-Hodgkin lymphomas


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Post-Traumatic Stress Disorder (PTSD);Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Violence Against Women;Violence Research;Women's Health Research

ORG_CITY: HOUSTON

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF HOUSTON

PHR: PUBLIC HEALTH RELEVANCE  Due to very high numbers of child exposure to Intimate Partner Violence (IPV) especially among African American women, coupled with devastating effects of IPV exposure on child psychosocial outcomes, there is a critical need to prevent the adverse effects of traumatic exposures on psychosocial outcomes in the context of health disparities. The proposed work has the potential to provide the first culturally sensitive, evidence-and community-based intervention that simultaneously addresses the needs of African American women and children affected by IPV, and which can be scaled up due to high affordability and low requirements for educational and clinical background of paraprofessional caseworkers. Once the efficacy of the MISC-IPV intervention has been tested and proven, it will have the potential to be adapted and used to address other public health epidemics across the country that are impeding supportive parenting and positive child development, such as families in which one or both parents are substance abusers, have serious mental illness or other disabilities, and/or are absent from the home due, for example, to incarceration or death.

PI_NAMEs: SHARP, CARLA  (contact)

PROGRAM_OFFICER_NAME: GILBERT, LEAH KAYE

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;Adverse effects;Affect;African American;African American Women;Age;Behavioral Symptoms;Buffers;caregiver education;caregiver interventions;Caregivers;caregiving;Caring;Cessation of life;Child;Child Development;Child Health;Child Rearing;Clinical;Communities;community advisory board;community intervention;coordinated violence;cost;Country;County;Coupled;Data;design;Development;disability;Domestic Violence;Education;effectiveness testing;efficacy testing;emotional symptom;Employment;Environment;Epidemic;Evaluation;evidence base;Exposure to;Family;Feedback;Focus Groups;follow-up;Frustration;Future;health disparity;Health Professional;HIV;Home;Housing;implementation evaluation;Imprisonment;improved;in vivo;in vivo evaluation;indexing;Individual;Interruption;Intervention;intervention effect;intervention program;Interview;intimate partner violence;Knowledge;Leadership;maternal caregiving;Mediating;Mediator;Mental Health;Methodology;Modeling;Mothers;Names;National Institute of Child Health and Human Development;Outcome;parenting intervention;Parents;Population;prevent;Process;process evaluation;programs;psychosocial;psychosocial outcome;Public Health;public health relevance;Questionnaires;Randomized;recruit;Research;resilience;scale up;Series;Services;severe mental illness;Site;skills;Standardization;Structure;substance abuser;Symptoms;Target Populations;Testing;tool;Training;Training Programs;Trauma;trauma symptom;traumatic stress;traumatized children;treatment as usual;treatment effect;violence exposure;Woman;Work

PROJECT_TITLE: MISC-IPV: A Community Based Intervention for Children Traumatized By Intimate Partner Violence

STUDY_SECTION: CLHP

STUDY_SECTION_NAME: Community-Level Health Promotion Study Section[CLHP]


NIH_SPENDING_CATS: Cancer

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative The goal of the proposed research plan is to define p53-mediated metabolic regulation program that is required for its tumor suppression as a mean to elucidate new targets/pathways for therapy. We expect that the research program will identify specific metabolic targets to suppress tumor growth without causing severe toxicity in normal tissues for therapy.

PI_NAMEs: GU, WEI  (contact)

PROGRAM_OFFICER_NAME: MAAS, STEFAN

PROJECT_TERMS: Apoptosis;cancer cell;cancer therapy;Cell Cycle Arrest;Cell Physiology;Development;Dissection;Event;Goals;Human;in vivo;Malignant Neoplasms;Mediating;Metabolic;Metabolic Pathway;Metabolism;Normal Cell;Normal tissue morphology;novel;Pathway interactions;Program Description;programs;Regulation;Research;Role;senescence;Tissue Therapy;Toxic effect;TP53 gene;transcription factor;tumor;tumor growth;Tumor Suppression

PROJECT_TITLE: p53-mediated metabolic regulation in tumor suppression


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Neurosciences;Orphan Drug;Rare Diseases

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Project Narrative This work aims to improve the use ultrasound combined with circulating microbubbles to temporarily disrupt the blood brain barrier, a property of blood vessels in the central nervous system that prevent most drugs from reaching the brain. The overall goal is to develop new tools and methods to overcome barriers that have emerged in clinical trials of this approach to getting drugs into the brain.

PI_NAMEs: MCDANNOLD, NATHAN J. (contact)

PROGRAM_OFFICER_NAME: ATANASIJEVIC, TATJANA

PROJECT_TERMS: Acoustics;Adverse event;Animal Experiments;Animals;attenuation;Back;bench to bedside;Blood - brain barrier anatomy;Blood Vessels;blood-brain barrier disruption;Brain;Brain Neoplasms;Calibration;Carboplatin;Cell Line;Central Nervous System;Central Nervous System Diseases;Cephalic;Clinic;Clinical;Clinical Treatment;Clinical Trials;clinically relevant;Contrast Media;cranium;detector;Disease;disease model;Dose;Drug Delivery Systems;early experience;effective therapy;Electronics;experience;experimental study;Focused Ultrasound;Future;Glioblastoma;Glioma;Goals;Growth;histological studies;Human;improved;improved outcome;Infiltration;Learning;Long-Term Effects;Mediating;Methods;Microbubbles;Modeling;Monitor;Motivation;Mus;Neurodegenerative Disorders;Noise;nonhuman primate;Nude Rats;patient derived xenograft model;Patients;Pharmaceutical Preparations;pre-clinical;Pre-Clinical Model;preclinical study;prevent;Procedures;Property;Protocols documentation;Rattus;Research;Safety;Sampling;Series;Signal Transduction;simulation;Sonication;Structure;success;System;Technology;Therapeutic;Therapeutic Agents;Tissues;tool;treatment planning;tumor;Tumor Burden;ultrasound;Validation;Variant;Visit;white matter;Work

PROJECT_TITLE: Optimization of ultrasound-mediated drug delivery to the brain under clinically relevant conditions

STUDY_SECTION: IGIS

STUDY_SECTION_NAME: Imaging Guided Interventions and Surgery Study Section[IGIS]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Drug Abuse (NIDA only);Electronic Nicotine Delivery Systems;Pediatric;Prevention;Social Determinants of Health;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PUBLIC HEALTH RELEVANCE We will conduct a comprehensive analysis assessing the impact of policies regulating electronic nicotine delivery systems (e-cigarettes, or ENDS) on the use of ENDS, combustible tobacco, and cannabis. In particular, we will assess whether these policies differentially affect youth, young adult, and adult use and we will project the impact of policy changes on health outcomes. These complementary analyses will address the vital need for a comprehensive evaluation of the impact of ENDS control policies and will be disseminated to key stakeholders, guidingthe implementation of policies that will maximize population health.

PI_NAMEs: LEVY, DOUGLAS  (contact)

PROGRAM_OFFICER_NAME: ROMBERG, ALEXA RUTH

PROJECT_TERMS: access restrictions;adolescent health;Adolescent Risk Behavior;Adopted;Adoption;Adult;Affect;Age;age group;Behavior;Behavioral;Behavioral Risk Factor Surveillance System;Boston;Cannabis;Categories;combustible cigarette;combustible tobacco;Communities;Complex;COVID-19 pandemic;Data;Data Set;Databases;Development;Electronic cigarette;Electronic Nicotine Delivery Systems;Empirical Research;Environment;Familiarity;Federal Government;follow-up;Future;Harm Reduction;Health;Health Professional;Health Surveys;Human Resources;Impact evaluation;implementation efforts;improved;Individual;indoor air;informant;interest;Interview;Laws;Legal;Licensing;Life Expectancy;Local Government;marijuana use;Marketing;Massachusetts;Modeling;models and simulation;Municipalities;Natural experiment;Nicotine;nicotine use;Outcome;Pattern;Policies;population health;programs;Public Health;public health relevance;Public Policy;public policy on tobacco;Qualitative Methods;Regulation;Research;Research Personnel;Sales;Schools;simulation;smoke-free policy;smoking cessation;Source;State Government;substance use;success;System;Taxation;Taxes;theories;Time;Tobacco;Tobacco use;tool;trend;United States Food and Drug Administration;vaping;vaping associated lung injury;vapor;Waxes;young adult;Youth

PROJECT_TITLE: Assessing the impact of vaping control policies at the school, local and state levels

STUDY_SECTION: CIHB

STUDY_SECTION_NAME: Community Influences on Health Behavior Study Section[CIHB]


ADMINISTERING_IC: DC

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Machine Learning and Artificial Intelligence;Neurosciences;Rare Diseases;Rehabilitation

ORG_DEPT: BIOMEDICAL ENGINEERING

PHR: Project Narrative This project seeks to design, test, and optimize a novel wireless recording array for a neural speech prosthetic. Patients with various types of motor disorders such as Amyotrophic lateral sclerosis (ALS) and Locked-in- Syndrome (LOS) can have difficulty or an inability to communicate. We aim to restore this ability by reading signals directly from the brain and translating them into speech. We will design and test novel high density, high channel-count electrodes to read from the brain at an unprecedented spatial scale. We will also develop wireless technology to enable this speech translation during everyday usage. With our advanced technology for reading the brain, we aim to literally give a voice to the voiceless.

PI_NAMEs: SHEPARD, KENNETH L;SOLZBACHER, FLORIAN ;VIVENTI, JONATHAN  (contact)

PROGRAM_OFFICER_NAME: MILLER, ROGER

PROJECT_TERMS: Algorithms;Amyotrophic Lateral Sclerosis;Area;Auditory;Auditory area;battery life;Brain;brain surgery;Clinical;Communication;Custom;Data;density;design;Development;Electrocorticogram;Electrodes;Electroencephalography;Environment;Eye Movements;Family;Friends;Generations;Health Personnel;high dimensionality;Human;Implant;improved;Infection prevention;infection risk;integrated circuit;liquid crystal polymer;Locked-In Syndrome;Machine Learning;machine learning algorithm;Maps;Measures;meter;Modeling;Motor Cortex;motor disorder;Muscular Dystrophies;Myopathy;neural;neural prosthesis;Neuromuscular Diseases;neurotransmission;novel;Patients;Performance;power consumption;Prosthesis;Quality of life;Reading;reading ability;reconstruction;Research;Resolution;Sampling;Self-Help Devices;signal processing;Signal Transduction;Speech;success;Techniques;Technology;Testing;Time;Training;Translating;Translations;Voice;wireless;Wireless Technology;Work

PROJECT_TITLE: A Wireless micro-ECoG Prosthesis for Speech

STUDY_SECTION: BNVT

STUDY_SECTION_NAME: Bioengineering of Neuroscience, Vision and Low Vision Technologies Study Section[BNVT]


ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Narrative Long-acting antiretroviral agents are expected to substantially improve the care of people living with HIV-1 by mitigating a number of pressing problems that include the necessity of daily administration of current HIV- 1 medications, suboptimal treatment adherence, and emergence of drug-resistant viral variants. The highly potent HIV-1 capsid inhibitor GS-6207 is an investigational principal component of long-acting antiretroviral therapy. We propose to study structural and mechanistic bases for the antiviral activity of GS-6207 and rationally develop second-generation compounds with a higher barrier to drug resistance.

PI_NAMEs: FUCHS, JAMES R;KVARATSKHELIA, MAMUKA  (contact)

PROGRAM_OFFICER_NAME: POON, BETTY

PROJECT_TERMS: Anti-Retroviral Agents;antiretroviral therapy;base;Binding;Binding Sites;Biochemistry;Biological;Biology;Capsid;Capsid Proteins;Caring;Cells;Chromatin;chronic infection;Clinical;cofactor;Collaborations;Cryoelectron Microscopy;Cytoplasm;Data;Deuterium;Disease;Distal;Dose;Drug resistance;drug resistant virus;Exhibits;experimental study;follow-up;gag Gene Products;Generations;Genes;HIV;HIV-1;HIV/AIDS;Hydrogen;Impairment;improved;Infection;inhibitor;insight;Knowledge;Life Cycle Stages;Manuscripts;Maps;Mediating;Modeling;Molecular;monomer;multimodality;novel;Nuclear Import;Persons;Pharmaceutical Chemistry;Pharmaceutical Preparations;Phase I Clinical Trials;Phase II/III Clinical Trial;Phenotype;Physiological;Play;preclinical study;prevent;Production;Proteins;rational design;Research;Resistance;Resolution;Roentgen Rays;Role;Science;Structure;Structure-Activity Relationship;targeted agent;Testing;therapeutic target;treatment adherence;Tube;Update;Variant;Viral;Viral Drug Resistance;Viral Physiology;Viral Proteins;viral resistance;virology;Virus;virus core;Virus Replication;X-Ray Crystallography

PROJECT_TITLE: Ultra-potent HIV capsid inhibitors


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: This proposal will evaluate immunity to influenza virus infection and vaccination in a new mouse model that more accurately captures cellular and molecular immune signatures seen in humans. Together this research will improve the preclinical pipeline for evaluating influenza virus vaccines to enhance translation potential.

PI_NAMEs: LANGLOIS, RYAN ;MASOPUST, DAVID  (contact)

PROGRAM_OFFICER_NAME: ARNOLD, MICHELLE MARIE

PROJECT_TERMS: Acceleration;Adjuvant;Adult;Animal Model;Animals;Antibodies;Antibody Response;antiviral immunity;Attenuated;Attenuated Vaccines;Biological Models;Body Weight decreased;C57BL/6 Mouse;Cells;Cellular biology;chronic infection;Complement;cost;Data;Disease;Environmental Risk Factor;Evaluation;experience;Ferrets;Gene Expression;Gene Expression Profile;Generations;Genetic;germ free condition;House mice;Human;human data;human disease;Immune;Immune response;Immune system;Immunity;immunogenic;immunogenicity;Immunologic Surveillance;improved;Inbred Strain;Infection;Influenza;influenza infection;Influenza prevention;Influenza vaccination;influenza virus vaccine;Innate Immune Response;Innate Immune System;Kinetics;Laboratory mice;Lung;Lymphocyte;Mediating;Memory;Methods;microbial;Modality;model organism;Modeling;Molecular;mouse model;Mucous Membrane;Mus;next generation;Parabiosis;pathogen;Pathogenesis;Pathogenicity;Pattern;Physiological;pre-clinical;Preclinical Testing;prevent;Reagent;Recording of previous events;Regimen;Research;Research Personnel;response;Safety;Sampling;Seasons;Serum;Severity of illness;Shapes;Speed;T cell response;T memory cell;T-Lymphocyte;Testing;Therapeutic Intervention;tissue resident memory T cell;Tissues;tool;Translating;translational potential;universal influenza vaccine;universal vaccine;Vaccination;Vaccine Adjuvant;vaccine candidate;vaccine development;vaccine immunogenicity;vaccine strategy;Vaccines;Viral;virology;Virus Replication

PROJECT_TITLE: New mouse model to better predict human immunity to influenza vaccination and infection

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDM-U(55)R]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Emerging Infectious Diseases;Hematology;Infectious Diseases;Microbiome;Regenerative Medicine;Sepsis;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: PROJECT NARRATIVE In patients undergoing hematopoietic stem cell transplantation, systemic infections with antibiotic resistant organisms often result from resident gut bacteria and are associated with an extremely high mortality rate. Despite the significant burden of multidrug-resistant infections, knowledge of how antibiotic resistance is acquired or disseminated in gut bacteria and contributes to the development of systemic infections is limited. This study will use novel next- generation sequencing of the gut flora to understand the antimicrobial resistance gene dynamics that may increase the risk of bloodstream infections in patients with cancer.

PI_NAMEs: ANDERMANN, TESSA  (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Accounting;Antibiotic Resistance;Antibiotic-resistant organism;Antibiotics;Antimicrobial Resistance;Award;Bacteria;Bacterial Antibiotic Resistance;Basic Science;biobank;Bioinformatics;bioinformatics tool;Blood Circulation;Cancer Center;career;Cessation of life;Clinical;Clinical Research;Clinical Trials;Clonal Expansion;cohort;colonization resistance;Communicable Diseases;Communities;Complex;Complication;Culture-independent methods;Data;Databases;Death Rate;design;Development;Disease;Doctor of Philosophy;Emerging Technologies;Enrollment;Environment;Exhibits;Feasibility Studies;Feces;Fellowship;Foundations;Frequencies;Funding;Future;Gene Transfer;Genes;Genome;Goals;gut bacteria;gut colonization;gut microbes;gut microbiome;gut microbiota;Hematologic Neoplasms;Hematopoietic Stem Cell Transplantation;Home;Horizontal Gene Transfer;Immunocompromised Host;in vivo;Infection;Infection prevention;infection risk;Inpatients;Institution;interest;Intervention;Investments;Knowledge;Leadership;Location;Malignant Neoplasms;Medical;Medicine;Mentored Patient-Oriented Research Career Development Award;Mentors;Metagenomics;Methods;Microbe;microbial;microbial genomics;Minority;Modeling;mortality;Multi-Drug Resistance;multi-drug resistant pathogen;Multicenter Studies;nanopore;Nature;next generation sequencing;North Carolina;novel;novel sequencing technology;Organism;Outpatients;participant enrollment;pathogen;patient oriented research;Patients;Population;post-transplant;prevent;professor;prospective;Randomized, Controlled Trials;Research;Resistance development;resistance gene;resistome;Risk;Scientist;Sepsis;Shotgun Sequencing;Shotguns;Specialist;stool sample;Systemic infection;Technology;Time;Training;Translational Research;Transplant Recipients;Transplantation;Universities;Validation;Wages;Work

PROJECT_TITLE: Precision characterization of antimicrobial resistance gene dynamics in bloodstream infection risk after hematopoietic stem cell transplantation

STUDY_SECTION: AITC

STUDY_SECTION_NAME: Allergy, Immunology, and Transplantation Research Committee[AITC]


ORG_CITY: TUCSON

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF ARIZONA

PHR: BEAMS NARRATIVE Childhood asthma leaves millions of children gasping for air and causes over two-hundred thousand hospitalizations each year, but we have no way to prevent it or cure it. In the Binational Early Asthma and Microbiome Study (BEAMS), we will determine which are the environmental microbes and their products present in the border city of Nogales, Mexico, that cause children born there to have four times less asthma than Mexican American children born in Tucson Arizona, just seventy miles north of the border. We will also determine the differences in microbial communities present in stools at both sides of the border, and the immune responses that asthma-protective microbes induce in both young children and mice, with the goal of using all this information to find ways to prevent asthma in the future.

PI_NAMEs: CARR, TARA F;LYNCH, SUSAN VERONICA;MARTINEZ, FERNANDO D (contact);ROSALES, CECILIA BALLESTEROS;VERCELLI, DONATA

PROGRAM_OFFICER_NAME: DONG, GANG

PROJECT_TERMS: 2 year old;Adult;Air;Allergic;American;Amish;analytical method;Animal Model;Animals;antimicrobial;Area;Arizona;Asthma;asthma model;asthma prevention;Biological Markers;Birth;Blood;Border Community;Border Crossings;Cells;Characteristics;Child;Childhood;Childhood Asthma;Cities;Clinical;clinical phenotype;Cytometry;Data;Development;drinking water;Dust;Enrollment;Environment;Environmental Exposure;Environmental Risk Factor;Eosinophilia;Epidemiology;Epigenetic Process;Ethnic Population;experience;experimental study;Exposure to;Farm;farmer;fecal metabolome;fecal microbiome;Feces;Future;Gene Expression;Genes;Genetic;Genomics;Geographic Locations;Germ-Free;Goals;gut microbiome;gut microbiota;Health;Home;Hospitalization;Human;Human Microbiome;hutterite;Hypersensitivity;Immune;immune function;Immune response;Immunity;Immunologic Markers;Immunologics;Immunology;improved;Infant;infant gut microbiome;innovation;Lactobacillus;Length;Life;Longitudinal cohort;Low Prevalence;Mainstreaming;maternal microbiome;Meconium;Metabolic;Mexican;Mexican Americans;Mexico;Microbe;microbial;microbial community;microbiome;microbiome research;microbiome therapeutics;microbiota;Modeling;Modification;Molecular;Mothers;mouse model;Mus;Natural experiment;Not Hispanic or Latino;offspring;Outcome;Pathway interactions;Pattern;peer;Population;postnatal;Poverty;Pregnancy;Pregnant Women;prenatal;Prevalence;prevent;Prevention strategy;Primary Prevention;Productivity;Program Research Project Grants;protective effect;recruit;Reporting;Risk;Rural Community;Sampling;Sanitation;Schools;Scientist;Series;Side;Statistical Methods;Time;United States;Wheezing

PROJECT_TITLE: Binational Early Asthma & Microbiome Study (BEAMS)


NIH_SPENDING_CATS: Lung

ORG_DEPT: ANATOMY/CELL BIOLOGY

PHR: Narrative In ICU patients ventilation is carried out by a machine, to facilitate oxygen uptake in the lungs, and the respiratory muscles become inactive. However, mechanical ventilation is a two-edged sword: during mechanical ventilation the diaphragm – the main respiratory muscle - rapidly weakens and prolonged mechanical ventilation is required. The goal of this proposal is to understand why the diaphragm is so extremely sensitive to inactivity during mechanical ventilation, and it will test the novel concept that super-relaxed myosins and the giant elastic muscle protein titin play a central role.

PI_NAMEs: OTTENHEIJM, COEN  (contact)

PROGRAM_OFFICER_NAME: ZHOU, GUOFEI

PROJECT_TERMS: Actins;Adopted;Affect;Animal Model;Atrophic;Attention;Attenuated;Binding;Biochemical;Biological Assay;Biopsy;clinically relevant;connectin;Contractile Proteins;Data;Depressed mood;Disease;Elasticity;experimental study;Extubation failure;Failure;Filament;Functional disorder;Genetic Engineering;Goals;Hand;Health;Heart Diseases;Hour;in vivo;Individual;innovation;insight;interdisciplinary approach;Laparotomy;Length;Light;Lung;Mass Spectrum Analysis;Measures;mechanical load;Mechanical ventilation;Mechanics;Mental Depression;Microfilaments;Modeling;Motor;mouse model;Mus;Muscle;Muscle Proteins;Muscular Atrophy;Myosin ATPase;nanometer resolution;novel;Oxygen;Patients;Pharmaceutical Preparations;Phosphorylation;Play;Positioning Attribute;Post-Translational Protein Processing;preservation;Production;programs;Protein Dephosphorylation;Proteins;Proteomics;Rattus;Relaxation;Research;Respiration;Respiratory Diaphragm;Respiratory Muscles;response;Role;Running;Sarcomeres;Skeletal Muscle;Testing;Therapeutic;tool;uptake;ventilation;Ventilator Weaning;Vertebral column;Weaning;Work;X ray diffraction analysis

PROJECT_TITLE: Role of titin in the pathophysiology of diaphragm weakness during mechanical ventilation

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]