ORG_CITY: HOUSTON

ORG_DEPT: PATHOLOGY

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE Neurodegeneration is the most widespread pathological defect found across neurological disorders. In the cerebellum, neurodegeneration is a well-established hallmark of ataxia, although its role in two of the most prevalent motor diseases, tremor and dystonia, remains hotly debated. This proposal seeks to determine how cerebellar neurodegeneration causes distinct functional alterations that initiate different motor diseases, with the ultimate goal of inspiring targeted therapeutic strategies that can restore normal motor function.

PI_NAMEs: DONOFRIO, SARAH  (contact)

PROGRAM_OFFICER_NAME: KIM, JENNY LILY

PROJECT_TERMS: Accelerometer;Address;Adult;Affect;Anatomy;Animal Model;Architecture;Ataxia;Automobile Driving;Autopsy;awake;Behavior;behavior test;Behavioral;behavioral outcome;Brain imaging;Categories;Cause of Death;Cell Death;cell type;Cells;Cerebellar Ataxia;Cerebellar degeneration;Cerebellar Diseases;Cerebellar Nuclei;Cerebellum;Cessation of life;Clinical;comorbidity;Consensus;Data;Deep Brain Stimulation;Defect;design;Deterioration;Development;Developmental Gene;Disease;Dystonia;Electromyography;Electrophysiology (science);end stage disease;Environment;Essential Tremor;experience;experimental study;Fellowship;functional outcomes;Genetic;Goals;Human;human imaging;Human Pathology;Imaging Techniques;immunohistochemical markers;Immunohistochemistry;in vivo;Individual;Label;Laboratories;Lead;Link;Measures;Modeling;Molecular;Motor;motor behavior;motor disorder;mouse genetics;mouse model;Mus;Muscle Contraction;Mutation;Nerve Degeneration;Nervous System Disorder;neural;Neuroanatomy;Neuronal Dysfunction;optogenetics;Output;Pathologic;Pathology;Patients;Pattern;Periodicity;Phenotype;Posture;Purkinje Cells;Research Personnel;Resolution;Resources;response;Rodent;Role;Shapes;Symptoms;targeted treatment;Testing;time use;Tissue Sample;Training;Tremor;Work;Writing

PROJECT_TITLE: Adult-onset Purkinje cell loss in cerebellar dysfunction


ADMINISTERING_IC: NR

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF NURSING

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: CORAL GABLES

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF MIAMI CORAL GABLES

ORG_STATE: FL

PHR: PROJECT NARRATIVE Neighborhood environment, a powerful social determinant of health, has a profound effect in shaping children’s physical, mental, and emotional health and in influencing opportunities for children to achieve long-term health. This project will explore the effect of neighborhood environment on child behavioral dysregulation and academic performance, and determine the degree to which family relationships, a modifiable factor, mediates the effect of neighborhood environment on behavioral dysregulation and academic performance in early childhood. This award will support my development toward becoming an independent nurse scientist dedicated to advancing the science in addressing social determinants of health and its effects on long-term child health and wellness.

PI_NAMEs: LEE, JIYE  (contact)

PROGRAM_OFFICER_NAME: GODETTE, DIONNE

PROJECT_TERMS: Acting Out;Address;Adopted;Affect;Award;Behavior;behavior influence;Behavioral;behavioral health;Biological;Brain;Capital;career;career development;Characteristics;Child;Child Development;Child Health;Child Rearing;Childhood;Chronic Disease;Clinical;cohesion;cohort;combat;coping;Data;Data Analyses;Data Element;Dedications;Development;Development Plans;early childhood;Economics;Education;Emotional;Emotional Bonds;emotional reaction;Environment;Equation;experience;Family;Family member;Family Relationship;Foundations;Funding;Geography;Goals;Growth and Development function;Health;health disparity;health economics;health equity promotion;Health Food;health inequalities;Human;Impairment;improved;Incidence;indexing;Inequity;Influentials;Intervention;Knowledge;Life;Longitudinal cohort;Mediating;Mediator;member;Mentors;Mentorship;Modeling;National Research Service Awards;Neighborhoods;Nurse Practitioners;Nurses;Outcome;Outcome Study;Parents;Pediatric Nursing;Performance;perinatal health;programs;Psyche structure;Psychopathology;Publications;Research;research and development;Research Methodology;Role;Sampling;Science;Scientist;Shapes;skills;social;social health determinants;Socioeconomic Status;Strategic Planning;Stress;United States National Institutes of Health;Work

PROJECT_TITLE: Effects of Neighborhood Environment on Child Behavioral Health

STUDY_SECTION: NRRC

STUDY_SECTION_NAME: Nursing Science Review Committee[NRRC(86)]


ADMINISTERING_IC: DC

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_CITY: PHILADELPHIA

ORG_NAME: DREXEL UNIVERSITY

ORG_STATE: PA

PHR: Project Narrative The goal of this proposal is to characterize how the neural signals encoding odor information for a biologically relevant segment of the fly olfactory system are transformed at critical points within this system. In doing so, we hope to identify how these signal transformations can be associated with changes in specific aspects of fly behavior, like whether they turn more or slow down when making sharp turns. By studying how these signals are transformed and how these transformations impact behavior, we hope to gain a better understanding of how the fly olfactory system influences the selection of specific motor programs during ongoing locomotion.

PI_NAMEs: WECHSLER, SAMUEL PAURA (contact)

PROGRAM_OFFICER_NAME: SCHURMAN, JACLYN REBECCA

PROJECT_TERMS: Affect;Anatomy;Animals;Behavior;Behavior assessment;behavior influence;behavior measurement;Behavioral;behavioral response;Binding;Brain;Bypass;cell type;Complex;Computer Models;connectome;Data;Data Set;Databases;Dendrites;Drosophila genus;Drosophila melanogaster;Electrons;Electrophysiology (science);Environment;Excision;experience;fly;Future;genetic approach;Goals;Horns;Image;Individual;insight;Knowledge;Laboratories;Lateral;Light;light intensity;Lobe;Locomotion;Maps;Maxilla;Measures;Modeling;Motor;Movement;Mushroom Bodies;Nervous System;neural;neural circuit;Neurons;Neurosciences;neurotransmission;Odors;Olfactory Pathways;olfactory receptor;Olfactory Receptor Neurons;optogenetics;Outcome;Output;Pattern;programs;Radial;receptor;Research;response;Role;Sensory;sensory input;sensory integration;Signal Transduction;Stereotyping;Stimulus;Synapses;System;Techniques;Time;Whole-Cell Recordings;Work

PROJECT_TITLE: Characterizing the Sensorimotor Transformation in Drosophila olfactory system


ADMINISTERING_IC: DA

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Brain Disorders;Cocaine;Drug Abuse (NIDA only);Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: RESEARCH TRIANGLE PARK

ORG_NAME: RESEARCH TRIANGLE INSTITUTE

ORG_STATE: NC

PHR: PROJECT NARRATIVE The studies in this proposal aim to develop therapeutics to normalize mitochondrial function in cocaine use disorders. Using viral strategies to knockout specific mitochondrial genes and fluorescent sensors to measure aspects of mitochondrial function in awake, behaving mice, we will be able to validate currently available mitochondrial therapeutics, as well as develop a pipeline for testing future mitochondrial drugs. These studies will significantly advance the chemistry and pharmacology of substance use disorders by exploring a novel treatment target and expanding the tools to dissect mitochondrial function.

PI_NAMEs: ABRAHAM, ANTONY DANIEL (contact)

PROGRAM_OFFICER_NAME: ANANTHAN, SUBRAMANIAM

PROJECT_TERMS: Adenosine Triphosphate;awake;Behavior;Calcium;calcium uniporter;Cardiolipins;Chemistry;Clustered Regularly Interspaced Short Palindromic Repeats;Cocaine;cocaine exposure;Cocaine use disorder;Complex;dopaminergic neuron;drug of abuse;Drug Targeting;Enzymes;Event;Excision;Fiber;Future;Generations;Genes;Health;Hydrogen Peroxide;in vivo;Knock-out;knockout gene;Lead;Measures;Mitochondria;Mitochondrial Matrix;Mitochondrial Proteins;mitochondrial therapeutics;Monitor;Mus;Neurons;Neurophysiology - biologic function;novel;Nucleus Accumbens;overdose death;Pharmaceutical Preparations;pharmacologic;Pharmacology;Phospholipids;Photometry;Presynaptic Terminals;Production;Proteins;Reactive Oxygen Species;Research;response;sensor;Signal Transduction;Specificity;Stimulant overdose;Substance Use Disorder;Superoxide Dismutase;Superoxides;Synapses;System;Testing;Therapeutic;tool;Viral

PROJECT_TITLE: Mitochondrial signaling dynamics in cocaine use disorder


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Genetic Testing;Genetics;Hematology;Lymphatic Research;Lymphoma;Rare Diseases

ORG_CITY: OMAHA

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: Project Narrative  Peripheral T-cell lymphoma (PTCL) is a group of heterogeneous disease entities with varied clinico- pathologic features, and ~ 30-50% of PTCL cases remain unclassifiable in current clinical practice. Using novel technological advances, we identified robust molecular classifiers and distinct genetic profiles, which can aid in molecular subclassification of PTCL. We plan to establish standardized, evidence-based procedures on bio- specimen processing for the optimal preservation of bio-analytes to ensure accurate and reproducible downstream assay performance using tissue and liquid biopsy of PTCL.

PI_NAMEs: CHAN, WING C.;IQBAL, JAVEED  (contact);MURTAZA, MUHAMMED

PROGRAM_OFFICER_NAME: GUAN, PING

PROJECT_TERMS: accurate diagnosis;Adult T-Cell Leukemia/Lymphoma;Affect;anaplastic lymphoma kinase;Biological;Biological Assay;Biopsy;Blood;Categories;cell free DNA;Classification;Clinical;clinical application;clinical center;Clinical Data;Clinical Laboratory Improvement Amendments;Clinical Pathology;clinical practice;Clinical Trials;Complex;Detection;Diagnosis;Diagnostic;diagnostic accuracy;diagnostic algorithm;diagnostic assay;diagnostic signature;diagnostic tool;diagnostic value;Disease;disease diagnosis;Disease Progression;DNA;DNA Maintenance;DNA Sequence Alteration;Ensure;Evaluation;evidence base;Extranodal;Formalin;Freezing;Future;GATA3 gene;Gene Expression;Gene Expression Profile;Genes;Genetic;genetic signature;genome analysis;Genotype;Goals;Immunoblastic Lymphadenopathy;Immunophenotyping;improved;International;Ki-1 Large-Cell Lymphoma;Laboratories;Lesion;liquid biopsy;Logistics;Measures;Messenger RNA;Methods;Molecular;Monitor;Morphology;Mutation;nano-string;new technology;Non-Hodgkin's Lymphoma;novel diagnostics;Outcome;Paraffin Embedding;Patients;Performance;Peripheral;Plasma;Plasma Cells;predicting response;preservation;Procedures;Process;Prognosis;prognostic;prognostic algorithm;prognostic assays;prognostication;prospective;Protocols documentation;Reproducibility;RNA;sample fixation;Sampling;Sensitivity and Specificity;Somatic Mutation;Specific qualifier value;Specimen;Standardization;Subgroup;T-Cell Lymphoma;Techniques;Tissue Banks;Tissue Embedding;tissue processing;Tissues;Translating;Transportation;treatment response;tumor;tumor DNA;Western World;whole genome

PROJECT_TITLE: Pre-analytical variables of bioanalytes affecting the accuracy of PTCL diagnostic and prognostic genetic signatures


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: TUCSON

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: OVERALL PROGRAM NARRATIVE Genetic factors play an important role in determining blood pressure variations and the development of hypertension, the No. 1 identifiable risk factor for disease burden and deaths worldwide. The findings from the studies in this PPG will address one of the most challenging and yet important questions in hypertension research and provide unprecedented insight into the genetic and epigenetic regulation of blood pressure and other complex human traits.

PI_NAMEs: LIANG, MINGYU  (contact)

PROGRAM_OFFICER_NAME: OH, YOUNGSUK

PROJECT_TERMS: Address;Animal Model;Area;arteriole;Base Pairing;Biological;Blood Pressure;blood pressure control;blood pressure regulation;Blood Vessels;burden of illness;cell type;Cells;Cessation of life;Characteristics;Chromatin;Chromatin Loop;Code;Complex;Data;Data Analyses;Data Set;Development;Disease;DNA;Enhancers;Epigenetic Process;epigenetic regulation;epigenome;experimental study;Gene Expression;Gene Expression Profiling;Genes;Genetic;genome editing;Genomics;Goals;Haplotypes;Human;Human Genome;human induced pluripotent stem cells;human tissue;Hypertension;in vivo Model;insight;Kidney;Knowledge;Link;Maps;Mediating;Modeling;Molecular Conformation;Nephrons;new technology;novel;novel strategies;Paper;Pathway interactions;permissiveness;Physiological;Play;programs;Proteins;Publishing;Rattus;Renin;Research;Research Personnel;Resistance;Risk Factors;Role;Single Nucleotide Polymorphism;stem cells;Testing;Tissues;trait;Untranslated RNA;Variant

PROJECT_TITLE: Genetic and Epigenetic Mechanisms of BP Regulation


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Colorectal Cancer;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: PROJECT NARRATIVE Colorectal cancer (CRC) is the second leading cause of cancer death among Chinese in the US. The goal of this proposal is to: (1) develop and pilot test CoLorectal Cancer Narrative Education and Navigation (CLEAN), a community-engaged intervention aimed at improving CRC screening in Chinese immigrants; and (2) provide Dr. Vang with mentored, hands-on and didactic training to acquire new knowledge and skills in community- engaged research and randomized controlled trials. This multimodal research and training plan will help Dr. Vang achieve independence as a behavioral health researcher and contribute to the elimination of cancer health disparities.

PI_NAMEs: VANG, SUZANNE SHARRY (contact)

PROGRAM_OFFICER_NAME: WALI, ANIL

PROJECT_TERMS: Address;Adoption;Adult;Age;Attention;barrier to care;behavioral health;Belief;Cancer Etiology;cancer health disparity;cancer prevention;career;Caring;Cessation of life;Chinese;Chinese American;Chinese population;Clinic;Clinical;Collection;Colonoscopy;Colorectal Cancer;colorectal cancer risk;colorectal cancer screening;Communities;community engaged intervention;community engaged research;community intervention;community organizations;Control Groups;Data;design;Detection;Disparity;Education;effective intervention;Eligibility Determination;Environment;evidence base;Excision;experience;Face;feasibility testing;Feces;Feedback;Focus Groups;Fostering;Foundations;Funding;Gatekeeping;Goals;Guidelines;Health;Health education;Health Insurance;Health Services Accessibility;Health system;Healthcare Systems;high school;Immigrant;Immigrant community;improved;Individual;Informal Social Control;innovation;Institution;Intervention;Interview;Knowledge;Language;Limited English Proficiency;Linguistics;Malignant Neoplasms;Manuscripts;meetings;member;Mentors;Methods;Minority;minority communities;Modeling;mortality;multimodality;Not Hispanic or Latino;Oncology;Pamphlets;patient navigation;Patient Recruitments;patient-level barriers;Patients;peer;Persons;Persuasive Communication;pilot test;Population;Poverty;Precancerous Polyp;prevent;Prevention;Preventive;Preventive care;programs;Provider;Publications;Randomized;Randomized, Controlled Trials;Recommendation;Reporting;Research;Research Activity;Research Personnel;Research Project Grants;Resources;role model;Scholarship;Screening for cancer;screening guidelines;skills;Social isolation;Social Network;Social Work;Spirituality;statistics;Structure;symposium;System;Testing;theories;Training;Training Activity;Training Programs;trial design;Trust;Underserved Population;United States;United States Preventative Services Task Force;Visualization;vulnerable community;Vulnerable Populations;Work

PROJECT_TITLE: CLEAN: A community-engaged intervention to increase colorectal cancer screening in Chinese American immigrants

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


NIH_SPENDING_CATS: Cardiovascular;Genetics;Hypertension

PROJECT_TERMS: Administrator;Annual Reports;blood pressure regulation;Communication;Contract Services;Ensure;Epigenetic Process;experience;Genetic;Goals;Human Resources;medical schools;meetings;Nature;Physiology;Play;programs;Research Personnel;Role;scientific organization;sound;success;Travel;United States National Institutes of Health;Visit;Wisconsin

PROJECT_TITLE: Administrative Core


PI_NAMEs: LIU, PENGYUAN  (contact)

PROJECT_TERMS: Adopted;ATAC-seq;bioinformatics pipeline;Biological;Blood Pressure;blood pressure control;blood pressure regulation;cell type;Cells;Charge;Chromatin;chromosome conformation capture;cost;Data;Data Analyses;Deposition;DNA;DNA Methylation;DNA-Protein Interaction;Dryness;Ensure;Epigenetic Process;epigenome;epigenome editing;experience;Fee-for-Service Plans;Generations;Genes;Genetic;genome editing;genome-wide;Goals;Hi-C;Human;Hypertension;improved;Individual;Interest Group;Laboratories;Libraries;Logistics;Maps;Measurement;Measures;member;Messenger RNA;methylation pattern;MicroRNAs;Molecular Conformation;next generation sequencing;Ontology;Pathway interactions;payment;Preparation;Process;Publications;Publishing;repository;Research;Research Personnel;RNA;Role;Sampling;Sequence Read Archive;Services;Single Nucleotide Polymorphism;success;Technology;Tissues;Transcript;transcriptome;transcriptome sequencing;Untranslated RNA;Work

PROJECT_TITLE: Sequencing Coordination and Data Analysis Core


ADMINISTERING_IC: EY

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: NORFOLK

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: OLD DOMINION UNIVERSITY

ORG_STATE: VA

PHR: We will use ultrafast fluorescence imaging to reveal how nanosecond-duration electric stimuli excite and inhibit neurons. We will scientifically justify, define, and test optimal stimulation protocols to evoke desired neuromodulation effects. We will utilize a novel interference targeting paradigm to elicit these neuromodulation effects selectively at a distance, for future applications such as non-invasive deep brain stimulation.

PI_NAMEs: PAKHOMOV, ANDREI G (contact)

PROGRAM_OFFICER_NAME: FLANDERS, MARTHA C

PROJECT_TERMS: Ablation;Action Potentials;Address;Affect;Animal Experiments;Animals;Apoptotic;bioelectricity;Biophysics;Bulla;Bypass;Cations;Cell Death;Cell membrane;Cell Physiology;Cell Size;Cells;Charge;Chronic;Complex;Cytoskeleton;Data;Deep Brain Stimulation;design;dielectric property;Disease;Distant;Dyes;electric field;Electric Stimulation;Electric Stimulation Therapy;Electrodes;Electrophysiology (science);Electroporation;Elements;Ensure;Event;Exposure to;Fluorescence;fluorescence imaging;Future;Goals;Health;Heating;high reward;high risk;Human;Image;imaging modality;imaging system;In Vitro;in vivo;innovation;Interdisciplinary Study;Ion Channel;Ion Channel Gating;Ions;Kinetics;Knowledge;Laser Microscopy;Lasers;Link;Maps;Medical;Membrane;Membrane Potentials;Membrane Proteins;Methods;Modality;Modeling;Monitor;nano;nanopore;nanosecond;Necrosis;Neural Inhibition;neural network;Neurons;Neurophysiology - biologic function;neuroregulation;Neurosciences;novel;Osmosis;outcome prediction;Outpatients;Phosphatidylinositol 4,5-Diphosphate;Photography;Physiologic pulse;Physiological;Property;Protocols documentation;receptor;Research;Resolution;response;Rest;Scientist;Second Messenger Systems;side effect;Signal Transduction;Stimulus;Stress;Swelling;temporal measurement;Testing;Time;Tissues;tool;tumor ablation;voltage;Work

PROJECT_TITLE: Targeted Neuromodulation by Nanosecond Pulsed Electric Fields


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: CHAMPAIGN

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

ORG_STATE: IL

PHR: The functional relationship between nuclear compartments and gene expression remains an enigma. Here we propose to identify components of known and still unknown nuclear “active niches”, using a novel combination of proteomics and omics proximity-labeling. Live-cell imaging will then determine the movements of genes and mRNAs to and from these active niches and determine the functional significance of these movements on gene expression exploiting the design of novel, low-cost, high-end microscopes.

PI_NAMEs: BELMONT, ANDREW STEVEN (contact);HAN, KYU YOUNG

PROGRAM_OFFICER_NAME: BLONDEL, OLIVIER

PROJECT_TERMS: Cells;Chromatin;Chromosome Mapping;Chromosomes;Computer software;cost;design;Enhancers;Gene Amplification;Gene Expression;Gene Order;Genes;Genetic Transcription;Genome Mappings;genome-wide;Genomics;Goals;Heat-Shock Response;Individual;Label;Laboratories;Length;Light;light microscopy;live cell imaging;live cell microscopy;Maps;Measures;Mediator;Messenger RNA;Methods;Microscope;Microscopy;Movement;mRNA Export;mRNA Precursor;novel;Nuclear;Nuclear Export;Nuclear Pore;Nuclear Structure;Phase;Physical condensation;Physiological;Positioning Attribute;Production;promoter;Property;Proteins;Proteomics;Reporter;Research;RNA;RNA Processing;RNA Splicing;Role;role model;Site;Speed;superresolution imaging;Technology;time use;Transcript;Transcription Elongation;Transgenes;Transgenic Organisms;Transplantation;Validation;Visualization;Work

PROJECT_TITLE: Identification of the active nuclear niche(s) using novel proteomic, genomic, transgenic, and live-cell microscopy technologies

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-A(70)R]


NIH_SPENDING_CATS: Cardiovascular;Genetics;Human Genome;Hypertension;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PROJECT_TERMS: Binding Sites;Bioinformatics;Blood Pressure;blood pressure regulation;Cell Differentiation process;Cell Line;Cell Reprogramming;cell type;Cells;Characteristics;Chromatin;Code;Complex;Data;differential expression;Distal;Distant;DNA;Engineering;Epigenetic Process;epigenomics;Exhibits;Female;Gene Expression;Gene Expression Regulation;Genes;Genetic;genome editing;genomic locus;Genotype-Tissue Expression Project;Goals;Haplotypes;Human;human induced pluripotent stem cells;Individual;induced pluripotent stem cell;interest;Limb structure;Linkage Disequilibrium;male;Methods;Minor;Phenotype;Physiological;Physiology;programs;promoter;Proteins;Protocols documentation;Proximal Kidney Tubules;Publishing;Quantitative Trait Loci;Series;Single Nucleotide Polymorphism;Testing;Thick;Tissues;trait;transcriptome sequencing;Untranslated RNA;Vascular Endothelium;Vascular Smooth Muscle

PROJECT_TITLE: Genes regulated by BP Noncoding SNPs in Relevant Cells


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Immunotherapy;Orphan Drug;Rare Diseases

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: PROJECT NARRATIVE Head and neck cancer relapses in half of all treated patients; relapsed disease does not respond well to new  therapies including those directed at boosting the body’s immune response against the tumor. We and others  determined that a protein called STAT3 promotes growth and survival of head and neck cancer cells and blocks  tumor immunity. We have developed a safe drug that effectively targets STAT3 that we propose to test in this  proposal for benefit in mouse models and patients with head and neck cancer.

PI_NAMEs: JOHNSON, FAYE ;SIKORA, ANDREW ;TWEARDY, DAVID JOHN (contact)

PROGRAM_OFFICER_NAME: SONG, MIN-KYUNG H

PROJECT_TERMS: advanced disease;Adverse event;Aftercare;anti-PD1 therapy;Antisense Oligonucleotides;Biological Availability;Biological Markers;Biopsy;Biotechnology;cancer cell;Cancer Center;Cancer Etiology;Cancer Relapse;cancer therapy;cell growth;Cell Proliferation;Cell Survival;Cells;Cessation of life;checkpoint therapy;chemotherapy;Clinical;clinical development;Clinical Trials;Computers;Correlative Study;design;Development;Disease;Docking;Drug Kinetics;Enrollment;Evaluable Disease;Excision;Gene Targeting;Growth;Head and Neck Cancer;Head and Neck Squamous Cell Carcinoma;Human;Immune;Immune checkpoint inhibitor;immune resistance;Immune response;Immunotherapy;improved;improved outcome;In complete remission;In Vitro;Individual;inhibitor;Lead;Link;liver injury;Malignant Neoplasms;Modeling;mouse model;Mus;Myeloid-derived suppressor cells;neoplastic cell;Nodal;novel;novel strategies;novel therapeutics;Nuclear;Operative Surgical Procedures;Oral;partial response;Patients;pembrolizumab;Pharmaceutical Preparations;Pharmacodynamics;Phase;phase 1 study;phase 2 designs;Phase Ib/II Clinical Trial;phase II trial;Placebos;Proteins;Radiation therapy;Randomized;Recurrence;Recurrent disease;Refractory;Relapse;Reporting;Research;Research Design;Resistance;response;Safety;Sampling;Serious Adverse Event;small molecule;Solid Neoplasm;STAT3 gene;success;Survival Rate;Testing;Therapeutic;Thrombocytopenia;Toxic effect;translational goal;tumor;tumor growth;Tumor Immunity;tumor microenvironment

PROJECT_TITLE: Targeting head and neck cancer cells and the adverse tumor microenvironment with a novel small-molecule STAT3 inhibitor

STUDY_SECTION: DT

STUDY_SECTION_NAME: Developmental Therapeutics Study Section[DT]


PI_NAMEs: GREENE, ANDREW S. (contact)

PROJECT_TERMS: Accounting;arteriole;ATAC-seq;Base Pairing;Bioinformatics;Biopsy;Blood Pressure;blood pressure control;blood pressure regulation;Cardiovascular Diseases;Cell Physiology;cell type;Cells;Chromatin;Chromatin Loop;Code;Data;Data Analyses;data exchange;Development;DNA;DNA analysis;DNA Methylation;DNA Sequence;DNA-Protein Interaction;Engineering;Enhancers;Environment;Epigenetic Process;epigenetic regulation;epigenome;epigenomics;Event;experimental study;Gene Expression;Genes;Genetic;Genome;genome editing;genome wide association study;genome-wide;Goals;Haplotypes;Heritability;Hi-C;Human;Human Genome;human tissue;Hypertension;Individual;induced pluripotent stem cell;Kidney;Knowledge;Laboratories;Link;Maps;Mediating;Myocardial Ischemia;Nephrons;Pathway interactions;Phenotype;Physiological;Physiology;Program Research Project Grants;Proteins;Reagent;Research;Research Personnel;Resistance;Resolution;Risk Factors;Role;Single Nucleotide Polymorphism;Stroke;Testing;Tissues;Untranslated RNA;Validation;validation studies;Variant;whole genome

PROJECT_TITLE: Epigenomes and Epigenetic Mechanisms in BP-relevant Tissues


NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Genetics;Prostate Cancer;Urologic Diseases

ORG_CITY: VANCOUVER

ORG_COUNTRY: CANADA

ORG_FIPS: CA

ORG_NAME: PROVINCIAL HEALTH SERVICES AUTHORITY

ORG_STATE: BC

ORG_ZIPCODE: V5Z 4E6

PHR: Project Narrative Expression of truncated constitutively active splice variants of androgen receptor is a major mechanism of resistance to current hormonal therapies for lethal metastatic castration-resistant prostate cancer. Here we propose the development of novel therapeutics and molecular imaging agents that could be used to treat and distinguish patients with metastatic lesions that express these splice variants. Our studies have important near and long-term clinical value to select patient treatments based on whether they express splice variants, monitor resistance mechanisms, and ultimately provide a novel treatment option to delay or prevent the terminal stage of prostate cancer.

PI_NAMEs: SADAR, MARIANNE D (contact)

PROGRAM_OFFICER_NAME: JOHNSON, ERIC MICHAEL

PROJECT_TERMS: abiraterone;Address;advanced prostate cancer;alternative treatment;analog;Androgen Antagonists;androgen independent prostate cancer;Androgen Receptor;antagonist;Binding;Biological Assay;Biological Markers;C-terminal;Cancer Patient;Castration;Clinical;clinical development;Clinical Management;Clinical Research;Clinical Trials;Complex;Cryoelectron Microscopy;Data;design and construction;Development;Disease;Dissociation;Dose;drug development;Drug Targeting;efficacy study;enzalutamide;first-in-human;Future;Gene Expression;Generations;Genetic Transcription;Goals;Growth;Hormonal;hormone therapy;Image;imaging agent;imaging approach;imaging study;Immunoprecipitation;improved;in vivo;Individual;inhibitor;insight;Length;Lesion;Ligand Binding Domain;Ligation;light scattering;Malignant neoplasm of prostate;Mass Spectrum Analysis;Measures;Mediating;Methods;molecular imaging;Monitor;N-terminal;Neoplasm Circulating Cells;Neoplasm Metastasis;new therapeutic target;next generation;novel;novel therapeutics;particle;Patient Selection;Patients;Pharmaceutical Preparations;pharmacodynamic biomarker;Phase I Clinical Trials;Positioning Attribute;Pre-Clinical Model;prevent;Prognosis;Proliferating;Property;protein protein interaction;Proteins;Receptor Activation;Receptor Signaling;Refractory;Resistance;resistance mechanism;Resolution;response;RNA Splicing;Sampling;scaffold;small molecule;Specificity;Stanolone;Structure;taxane;Technology;Testing;Therapeutic;therapy resistant;Time;transcription factor;transcriptome sequencing;treatment choice;treatment response;uptake;Variant;whole body imaging;X-Ray Crystallography

PROJECT_TITLE: Structure, function, and application of novel antagonists of the intrinsically disordered androgen receptor amino-terminal domain as imaging agents and therapeutics

STUDY_SECTION: DMP

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology Study Section[DMP]


PI_NAMEs: GEURTS, ARON M (contact)

PROJECT_TERMS: Accounting;Affect;Alleles;Animal Model;Architecture;ATAC-seq;Base Pairing;Binding Sites;Blood Pressure;blood pressure control;blood pressure regulation;Blood Vessels;candidate identification;Cardiovascular Diseases;CCCTC-binding factor;cell type;Cells;Chromatin;Chromatin Structure;Chromosome Mapping;Chromosomes;comparative;Complex;Conscious;CRISPR/Cas technology;Data;data exchange;Disease;Distal;DNA;DNA Binding Domain;DNA methylation profiling;DNA-Binding Proteins;Encyclopedia of DNA Elements;Endothelium;Engineering;Environment;Epigenetic Process;epigenomics;Event;gene editing technology;Gene Expression;gene interaction;Genes;Genetic;Genetic Enhancer Element;genetic manipulation;genetic variant;Genetic Variation;Genome;genome wide association study;genome-wide;genomic profiling;Goals;Haplotypes;Heritability;Hi-C;Human;Human Genome;Hypertension;in vivo;Interruption;Kidney;Laboratories;Link;Location;Maps;Mediating;Molecular;Molecular Conformation;Mutate;Myocardial Ischemia;Nephrons;Program Research Project Grants;promoter;Proteins;Rattus;Reagent;Renin;Research Personnel;response;Risk Factors;Role;Single Nucleotide Polymorphism;Site;Smooth Muscle Myocytes;Stimulus;Stroke;Techniques;Testing;Tissues;trait;transcriptome sequencing;Untranslated RNA;Variant;Vascular Smooth Muscle

PROJECT_TITLE: Role of chromatin conformation in BP Regulation


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Depression;Mental Health;Mental Illness;Palliative Care;Rehabilitation

ORG_DEPT: PSYCHIATRY

PHR: Project Narrative: Psychiatric and existential distress is common among patients with life-limiting cancer and effective pharmacologic-behavior treatments are lacking. The proposed research is relevant to public health because it focuses on improving the lives of people with life-limiting cancer by seeking to decrease depression, anxiety and existential distress, while improving quality-of-life (QOL). We anticipate this research will help reduce the burden of suffering for persons with advanced cancer.

PI_NAMEs: FISCHER, STACY M;ROSS, STEPHEN  (contact)

PROGRAM_OFFICER_NAME: ALTSHULER, RACHEL DINA

PROJECT_TERMS: Acute;Address;Adjustment Disorders;Advanced Malignant Neoplasm;Adverse effects;Affect;anti-depressive agents;Anxiety;Anxiety Disorders;Attention;Behavior;Behavior Therapy;cancer care;cancer diagnosis;Cancer Patient;cancer survival;cancer therapy;Cessation of life;Clinical;clinical care;Clinical Research;clinically significant;Cognition;Cognitive;common treatment;completed suicide;Data;death anxiety;design;disability;Distress;Dose;Double-Blind Method;dysphoria;effective therapy;Effectiveness;efficacy evaluation;Emotional;emotional distress;Ensure;Environment;Evidence based intervention;experience;Feeling hopeless;flexibility;follow-up;Foundations;Goals;Hallucinogens;Health;Hour;Human;improved;innovation;Integrative Therapy;Intervention;Life;life-limiting cancer;Long-Term Depression;Long-Term Effects;Major Depressive Disorder;Malignant Neoplasms;Manuals;Measures;medication compliance;medication nonadherence;Mental Depression;Mental disorders;Mental Health;mental state;Mind;Moods;mortality;novel therapeutic intervention;open label;Outcome;Outcome Study;Pain;Participant;Patient Care;Patient Self-Report;Patients;peace;Personality Traits;Persons;Pharmaceutical Preparations;pharmacologic;Physiological;Placebo Control;placebo group;Placebos;Preparation;Prevalence;Psilocybin;psychiatric comorbidity;psychologic;psychosocial;Psychotherapy;Public Health;Quality of life;Randomized;Randomized, Controlled Trials;Relapse;Research;response;Safety;Sampling;Science;SEER Program;Site;Spiritual well-being;Spirituality;success;Survival Rate;Testing;Therapeutic;Therapeutic Uses;Time;trait;Treatment Efficacy;Treatment Protocols;Tryptamines;Work

PROJECT_TITLE: Psilocybin Therapy for Advanced Cancer-related Psychiatric Distress

STUDY_SECTION: BMHO

STUDY_SECTION_NAME: Biobehavioral Medicine and Health Outcomes Study Section[BMHO]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Colorectal Cancer;Digestive Diseases;Genetics;Hematology;Human Genome;Liver Cancer;Liver Disease;Lymphatic Research;Lymphoma;Orphan Drug;Pancreatic Cancer;Rare Diseases

ORG_CITY: STONY BROOK

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

PHR: Project Narrative p53 is the most frequently altered gene occurring in > 50% of human cancers. Perturbations in p53 signaling are required for development of most cancers. In contrast to other tumor suppressors, the vast majority of p53 alterations are missense mutations in the DNA-binding domain (‘mutp53’), leading to conformationally aberrant highly stabilized mutp53 proteins. Mouse models and clinical data from germline and sporadic cancers firmly established that missense mutp53 proteins not only lose their tumor suppressor function, but often acquire new oncogenic gain-of-function activities mutp53GOF. As major translational advance, our preliminary data established a strong exploitable dependency on continued high expression of mutp53 for tumor growth, maintenance and metastasis in autochthonous models of lymphoma and colorectal carcinoma. Our research program aims to evaluate the therapeutic potential of this concept in liver and pancreatic cancer, elucidate the mechanisms behind mutp53GO-driven tumorigenesis, with the ultimate goal to identify novel therapeutic targets for mutp53 cancers.

PI_NAMEs: NEMAJEROVA, ALICE  (contact)

PROGRAM_OFFICER_NAME: CERO, CHERYL

PROJECT_TERMS: Ablation;Acceleration;Address;Alleles;Area;Biological;Cancer Patient;cancer therapy;cancer type;Carcinoma;Chemoresistance;ChIP-seq;Clinical;Clinical Data;Collaborations;Colorectal Cancer;cytotoxicity;Data;Death Rate;Dependence;design;Development;DNA Binding Domain;Frequencies;gain of function;Genes;Genetic;Germ Lines;Germ-Line Mutation;Goals;graduate student;Human;in vivo;Infrastructure;inhibitor;Invaded;Knock-in Mouse;Laboratories;Large Intestine Carcinoma;Lead;liver cancer model;Lymphoma;Maintenance;Malignant - descriptor;Malignant neoplasm of liver;Malignant neoplasm of pancreas;Malignant Neoplasms;Metabolism;Missense Mutation;Modeling;Molecular;Molecular Conformation;mortality;mouse model;Mouse Strains;Mus;mutant;Mutation;Neoplasm Metastasis;new therapeutic target;Oncogenic;Patients;pharmacologic;Phenotype;Population;Postdoctoral Fellow;pre-clinical;programs;Proliferating;Proteins;Proteome;Research;Research Personnel;Signal Transduction;single-cell RNA sequencing;technology development;Testing;The Cancer Genome Atlas;Therapeutic;time use;TP53 gene;Training;Translating;translational progress;tumor;tumor growth;Tumor Suppressor Proteins;tumorigenesis;undergraduate student;Work

PROJECT_TITLE: Mutant p53 gain-of-function as an actionable target in cancer therapy


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Cardiovascular;Heart Disease

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: PROJECT NARRATIVE This Multidisciplinary Research Training Program in Cardiovascular Disease addresses the critical need for more physician-scientists and scientists focused on cardiovascular physiology and diseases. This Program will provide postdoctoral fellows with rigorous, personalized and state-of-the-art research training. The overarching goal is to equip outstanding young researchers with the knowledge and skills required to accelerate the translation of basic science discoveries into new approaches to the diagnosis and management of cardiovascular disease.

PI_NAMEs: PITT, GEOFFREY S (contact);WEINSAFT, JONATHAN W.

PROGRAM_OFFICER_NAME: WEBB, STEPHANIE JOHNSON

PROJECT_TERMS: Cardiovascular Diseases;Interdisciplinary Study;Research Training

PROJECT_TITLE: Multidisciplinary Research Training in Cardiovascular Disease

STUDY_SECTION: NITM

STUDY_SECTION_NAME: NHLBI Institutional Training Mechanism Study Section[NITM(JA)]


ADMINISTERING_IC: MD

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: Public Health Impact The “UCLA-UCI Center for Eliminating Cardiometabolic Disparities in Multi-Ethnic Populations” (UC END- DISPARITIES) will address the inequitable multilevel factors, including structural disadvantage, that accelerate the development and progression of cardiometabolic disease and disproportionately affect low-income and minority groups. The center will function across the highly diverse communities that comprise Los Angeles County and Orange County (combined population over 13 million, more than 46 states). UC END- DISPARITIES will work to prevent cardiometabolic disease, reduce its harmful impact in minority communities, and develop equitable community-partnered research approaches to meet these objectives via three integrated cores, three center research projects, and training programs for new investigators, all working to develop innovative community-relevant approaches to cardiometabolic disease prevention and treatment for southern California's vulnerable communities and at-risk patient populations.

PI_NAMEs: BODEN-ALBALA, BERNADETTE MARIE;BROWN, ARLEEN F. (contact);NORRIS, KEITH C

PROGRAM_OFFICER_NAME: HUELSNITZ, CHLOE OLIVIA

PROJECT_TERMS: Acceleration;Affect;Aging;allostatic load;American Indian community;Asian;Atherosclerosis;Award;Behavioral;Biometry;Black race;California;Cardiometabolic Disease;cardiometabolic risk;cardiometabolism;Cardiovascular system;care outcomes;career;catalyst;Chronic;Chronic Disease;Chronic Kidney Failure;Clinical Research;Clinical Sciences;Collaborations;Communication;Communities;community academic partnership;community engaged research;community engagement;County;data harmonization;Data Set;data sharing;design;Development;Diabetes Mellitus;Disadvantaged;Discrimination;disease disparity;disorder prevention;Disparity;Economics;Equity;Ethnic Population;Evaluation;Family;flexibility;Funding;Future;Goals;Health;health disparity;health equity;Health equity research;health information technology;Health Policy;Health system;Hypertension;implementation science;improved;Individual;Inequity;inflammatory marker;Infrastructure;innovation;Institution;Intervention;Latino;Link;Los Angeles;Low income;marginalized population;Measurement;Measures;meetings;Mentors;Mentorship;Methodology;Minority;minority communities;Minority Groups;Minority Health Research;Minority-Serving Institution;Morbidity - disease rate;mortality;multi-ethnic;National Institute of General Medical Sciences;National Institute on Minority Health and Health Disparities;Oranges;Outcome;Outcomes Research;Pacific Islander;Participant;patient population;PhenX Toolkit;Pilot Projects;Population;Postdoctoral Fellow;premature;prevent;programs;Public Health;Reduce health disparities;Research;Research Infrastructure;Research Institute;Research Methodology;Research Personnel;Research Project Grants;Resource Sharing;Resources;Risk;Risk Factors;social;social genomics;social health determinants;Stress;structural determinants;synergism;therapy design;tool;Training;Training Programs;Translational Research;United States National Institutes of Health;vulnerable community;Work

PROJECT_TITLE: UCLA-UCI Center for Eliminating Cardio-Metabolic Disparities in Multi-Ethnic Populations (UC END-DISPARITIES)


NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Social Determinants of Health

PI_NAMEs: BODEN-ALBALA, BERNADETTE MARIE;BROWN, ARLEEN F. (contact)

PROJECT_TERMS: Address;Affect;Area;Award;California;Cardiometabolic Disease;cardiometabolism;career;Caring;catalyst;Chronic Disease;Chronic Kidney Failure;Collaborations;Communication;Communities;community engagement;community partners;County;Data Collection;data harmonization;data sharing;data standards;Development;Diabetes Mellitus;disease disparity;Disparity;disparity elimination;Ensure;Equipment;Equity;Ethnic Population;Evaluation;Funding;Grant;health equity;Hypertension;Infrastructure;Institution;interest;Intervention;Lead;Leadership;Los Angeles;Measurement;medically underserved;meetings;Mentors;Monitor;multi-ethnic;multiple chronic conditions;National Institute on Minority Health and Health Disparities;Oranges;Patients;Pilot Projects;Prevention;Procedures;programs;Protocols documentation;Recommendation;recruit;Research;Research Personnel;Resources;Risk Factors;safety net;Secure;social health determinants;Stroke;Structure;Training;United States National Institutes of Health;Vulnerable Populations

PROJECT_TITLE: Admin Core


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Bioengineering;Biotechnology;Brain Disorders;Cardiovascular;Heart Disease;Immunotherapy;Multiple Sclerosis;Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: BALTIMORE

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Narrative: As many as 23.5 million Americans suffer from autoimmune dieses and current therapies are non-curative and often systemically immunosuppressive, increasing the risk of opportunistic infections and cancer. The aim of this proposal is to develop an antigen-specific immunotherapy that upon intranasal administration binds to nasal mucus, passes via paracellular transport to the nasal immune system, and actively programs dendritic cells to generate autoantigen-specific regulatory T cells that suppress autoimmunity. Completion of this project will demonstrate the efficacy of a clinically-viable cure for autoimmunity in a preclinical model of autoimmune myocarditis and establish a platform technology that can be easily modified to treat various autoimmune and allergic dieses as well as transplant rejection.

PI_NAMEs: WILSON, DAVID SCOTT (contact)

PROGRAM_OFFICER_NAME: MORRIS FEARS, MARGARET A

PROJECT_TERMS: Allergens;Allergic;Allergic Disease;American;Animal Model;Antigens;Autoantigens;Autoimmune;Autoimmune Diseases;Autoimmune myocarditis;Autoimmune Responses;Autoimmunity;Binding;Biocompatible Materials;Cardiac;Cardiac Myosins;Clinical;clinical translation;Dendritic Cells;design;Development;Dexamethasone;di-block copolymer;Diabetes Mellitus;Dilated Cardiomyopathy;Disease;efficacy validation;Engineering;Epithelium;Experimental Models;Fibrosis;Flow Cytometry;Formulation;Goals;Graft Rejection;heart function;Histology;Hypersensitivity;IL2RA gene;Image Cytometry;Immune;immune cell infiltrate;Immune response;Immune system;Immunize;immunoregulation;Immunosuppression;Immunotherapy;Infection;infection risk;Inflammatory;Infusion procedures;Injections;Intranasal Administration;Label;Liver;Lymphoid Tissue;Malignant Neoplasms;Measures;Mediating;Minocycline;monomer;mouse model;Mucous body substance;Multiple Sclerosis;Mus;Myocarditis;Nasal Epithelium;nonhuman primate;Nose;novel;Opportunistic Infections;Ovalbumin;Pain;Pathogenicity;Pathology;Patient Compliance;Patients;Peptides;Phagocytes;Phenotype;Phosphatidylserines;Play;Polymers;pre-clinical;Pre-Clinical Model;prevent;programs;receptor;Regulatory T-Lymphocyte;response;Risk;Severities;Signal Induction;small molecule;Sulfhydryl Compounds;Symptoms;T-Lymphocyte;Technology;technology platform;Therapeutic;Tight Junctions;Water;whole animal imaging;Work

PROJECT_TITLE: Tolerance-programming biomaterial-based Intranasal ASIT for the treatment of autoimmunity


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: SORKIN, DARA H.;WASHINGTON, DONNA  (contact)

PROJECT_TERMS: Acceleration;Active Learning;Affect;analytical method;Annual Reports;Behavioral;Behavioral Sciences;Biological;built environment;California;Cardiometabolic Disease;cardiometabolism;career;career development;Chronic Disease;cognitive interview;Communities;Community Health;Community Participation;Complex;Data;Development;Disadvantaged;disease disparity;Disparity;Early identification;Elements;Environment;Equity;ethnic minority;Ethnic Population;Evolution;experience;Exposure to;Faculty;Focus Groups;Funding;Goals;Group Interviews;Health Disparities Research;health disparity;Healthcare Systems;improved;Individual;innovation;Intervention;Leadership;Learning;learning community;low socioeconomic status;Measurement;Measures;Mentors;Mentorship;Methodology;Methods;Minority Health Research;Modification;Motivation;multi-ethnic;National Institute on Minority Health and Health Disparities;Nature;next generation;Personality;Pilot Projects;Population Heterogeneity;Populations at Risk;Postdoctoral Fellow;Procedures;Process;Program Research Project Grants;programs;racial minority;Research;Research Personnel;Research Project Grants;Resources;Risk Factors;Role;Science;Scientist;secondary analysis;Shapes;social;social cognitive theory;social culture;Structure;success;Talents;theories;tool;Training;Training Programs;Underrepresented Populations;United States National Institutes of Health;Work

PROJECT_TITLE: Investigator Development Core


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

PHR: Hepatocellular carcinoma (HCC) is a very common and lethal cancer in Africa, and as patients with HIV live longer, the burden of HCC may increase. The proposed Consortium will conduct clinical research projects in Uganda and Senegal to investigate if and how treatment of HCC- causing infections may prevent HCC. In parallel, Consortium resources are applied towards developing human and clinical research capacity in both countries to address the growing problem of HIV and HCC.

PI_NAMEs: KIRK, GREGORY D (contact);OCAMA, PONSIANO

PROGRAM_OFFICER_NAME: DOMINGUEZ, GERALDINA

PROJECT_TERMS: Address;Adopted;Advocate;Africa;Africa South of the Sahara;African;Age;Aging;antiretroviral therapy;Award;biobank;Biological Markers;biomarker discovery;career development;Cause of Death;Chronic;chronic infection;Clinical;Clinical Data;Clinical Research;clinical translation;co-infection;cohort;Collaborations;Country;curative treatments;Data;data quality;design;Development;Early identification;effective therapy;Epidemiology;Etiology;Funding;Goals;Hepatitis B Infection;Hepatitis B Therapy;Hepatitis B Virus;Hepatitis C;Hepatitis C virus;Hepatocarcinogenesis;high risk population;HIV;HIV Infections;Human;Immune response;improved;Incidence;Individual;Infection;Infrastructure;innovation;Interruption;Intervention;Investigation;Investments;Lead;Liver;Liver diseases;Liver Fibrosis;Malignant Neoplasms;Measurement;Medical;Mentors;Monitor;mortality;multidisciplinary;novel;novel marker;Oncogenes;Pathway interactions;Patients;Persons;Pilot Projects;Population;Population Research;Praziquantel;predictive marker;prevent;Prevention strategy;Primary carcinoma of the liver cells;Process;prospective;Prospective cohort;recruit;Research;Research Design;Research Infrastructure;Research Personnel;Research Project Grants;Resource-limited setting;Resources;response;Risk;Risk Factors;scale up;Schistosoma mansonii infection;screening;Senegal;Serum Albumin;success;Translational Research;translational study;treatment strategy;Uganda;United States National Institutes of Health;Universities;Viral hepatitis

PROJECT_TITLE: HIV and HCC in Africa: The H2A Consortium


NIH_SPENDING_CATS: Cancer;Digestive Diseases;HIV/AIDS;Hepatitis;Infectious Diseases;Liver Cancer;Liver Disease;Rare Diseases

PI_NAMEs: KIRK, GREGORY D (contact)

PROJECT_TERMS: Accounting;Advocate;Africa;Africa South of the Sahara;African;Age;Biological Specimen Banks;Cell Nucleus;chronic infection;Clinical;Collaborations;Communication;Communities;community advisory board;Computer software;Country;Data Collection;data harmonization;data sharing;Database Management Systems;Development;Documentation;Education;Electronic Mail;Ensure;Equity;expectation;Face;Generations;Goals;Grant;Hepatitis B Infection;Hepatitis C virus;HIV;Human;human subject protection;Infection;International;Interruption;Lead;Leadership;Link;Malignant Neoplasms;Medical;meetings;Mentors;Monitor;Online Systems;organizational structure;participant retention;Patient Recruitments;Patients;Peer Review;Periodicals;Policies;Preparation;Primary carcinoma of the liver cells;Problem Solving;programs;Progress Reports;Public Relations;Publications;Reporting;Research;Research Personnel;Resources;Review Literature;Risk Factors;Role;Schistosoma mansonii infection;Senegal;Site;Structure;Supervision;symposium;Training;Uganda;Universities;web site;Work

PROJECT_TITLE: H2A Admin Core


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: NORRIS, KEITH C (contact);TANJASIRI, SORA P

PROJECT_TERMS: Address;Advocacy;Award;Awareness;Behavioral;Behavioral trial;Biological;Cardiometabolic Disease;cardiometabolism;catalyst;Chronic;Clinical;Clinical Trials;Collaborations;Communication;Communities;community academic partnership;Community Actions;community based participatory approach;Community Developments;community engaged approach;community engaged research;community engagement;Community Health;community organizations;community partnership;community planning;County;Development;Diabetes Mellitus;Disparity;disparity reduction;Enrollment;Environment;Equity;Ethnic Origin;Ethnic Population;experience;Feedback;Foundations;Goals;health disparity;health equity;Health Promotion and Education;Health system;Hypertension;improved;Individual;Inequity;Infrastructure;innovation;Institution;Intervention;Knowledge;leadership development;Lived experience;Los Angeles;Mediating;member;Methods;Morbidity - disease rate;mortality;multi-ethnic;National Institute on Minority Health and Health Disparities;next generation;novel;novel strategies;Oranges;Outcome;Participant;Patients;peer;Pilot Projects;Policies;Policy Maker;Policy Making;policy recommendation;Prevention;Prevention approach;Process;Recommendation;recruit;Reduce health disparities;Research;Research Personnel;Research Project Grants;Resources;Risk Factors;Risk Reduction;social;social culture;social determinants;Solid;Stroke;structural health determinants;Structure;System;Techniques;Training;Translations;Trust;Voice;Vulnerable Populations;Work

PROJECT_TITLE: Community Engagement Core


NIH_SPENDING_CATS: Cancer;Clinical Research;Digestive Diseases;HIV/AIDS;Hepatitis;Infectious Diseases;Liver Cancer;Liver Disease;Rare Diseases

PI_NAMEs: AIZIRE, JIM K (contact)

PROJECT_TERMS: Adherence;Advocate;Africa;Africa South of the Sahara;African;Age;Behavioral;career;chronic infection;Clinical;clinical research site;cohort;Complex;Country;Data;Data Collection;data dictionary;Data Element;data harmonization;data integration;data quality;Data Set;design;Development;Electronics;Ensure;Europe;Evaluation;experience;Goals;Hepatitis B Infection;Hepatitis C virus;HIV;Hospitals;Image;Infection;Interruption;Interview;Laboratories;Language;Lead;Leadership;Malignant Neoplasms;Measurement;Measures;Medical;Mentors;Methods;Monitor;novel;Participant;Patients;Performance;Periodicals;Pilot Projects;Primary carcinoma of the liver cells;Procedures;Process;Protocols documentation;quality assurance;Questionnaires;recruit;Research;Research Personnel;research study;Resources;response;Risk Factors;Role;Schistosoma mansonii infection;Secondary to;Senegal;Site;Standardization;Switzerland;Technology Transfer;Telemedicine;Testing;Training;Uganda;Universities

PROJECT_TITLE: H2A Clinical Core


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Cancer

ORG_CITY: GLASSBORO

ORG_DEPT: CHEMISTRY

ORG_NAME: ROWAN UNIVERSITY

ORG_STATE: NJ

PHR: The discovery of BRAF as a major driver of human cancers led to a substantial clinical success of current BRAF therapies, however, the incomplete understanding of various biological processes that RAF kinases participate has hindered the development of more effective BRAF drugs. We propose to integrate chemical, biochemical, and biophysical tools together with mass spectrometry and cell imaging to address the molecular mechanisms of RAF activation and regulation in normal and disease conditions, specifically cancer. Our findings will provide fundamental insights into how RAF kinases operate at the molecular level and will have an impact on the treatment of BRAF-driven cancers.

PI_NAMEs: WANG, ZHIHONG  (contact)

PROGRAM_OFFICER_NAME: LEWIS, MECHELLE MAYLEBEN

PROJECT_TERMS: Address;Affinity;Allosteric Regulation;Binding;Binding Sites;Biochemical;biochemical tools;Biological Assay;Biological Process;Biology;biophysical tools;BRAF gene;CDK4 gene;Cells;cellular imaging;chaperone machinery;Chemicals;Client;Clinical;Co-Immunoprecipitations;Complex;Computing Methodologies;Development;dimer;Dimerization;Disease;Dissociation;Drug resistance;Elements;Engineering;Enzymes;Event;Family;Goals;Growth Factor Receptors;Health;Human;In Vitro;inhibitor;insight;interdisciplinary approach;Intervention;Kinetics;Knowledge;Length;live cell imaging;Malignant Neoplasms;MAP Kinase Gene;MAPK Signaling Pathway Pathway;Mass Spectrum Analysis;Measures;Mediating;member;Membrane;Modeling;Molecular;Molecular Conformation;molecular dynamics;multicatalytic endopeptidase complex;mutant;Mutate;Mutation;Mutation Analysis;N-terminal;novel therapeutic intervention;Nucleotides;Oncogenic;Outcome;Output;paralogous gene;Pathologic;Pathway interactions;Peptides;Pharmaceutical Preparations;pharmacologic;phosphoproteomics;Phosphorylation;Phosphotransferases;Photoaffinity Labels;Physiological;Positioning Attribute;preference;Proliferating;protein degradation;Protein Family;Protein Isoforms;Protein Kinase;Protein-Serine-Threonine Kinases;Proteins;Proto-Oncogene Proteins B-raf;prototype;raf Kinases;RAS genes;Ras/Raf;recruit;Regulation;Research;Second Primary Cancers;Serine;Signal Transduction;Sirolimus;Specificity;Structure;success;synergism;System;Tacrolimus Binding Proteins;targeted cancer therapy;Therapeutic;tumor;tumorigenesis;Variant;Work;X-Ray Crystallography

PROJECT_TITLE: Activation and Regulation Mechanisms of the RAF Kinase Family

STUDY_SECTION: MSFA

STUDY_SECTION_NAME: Macromolecular Structure and Function A Study Section[MSFA]


PROJECT_TERMS: Advocate;Africa;Africa South of the Sahara;African;Age;anti-cancer research;Award;career;career development;Career Mobility;chronic infection;Clinical;Clinical Research;Collaborations;Complement;Country;design;Development;faculty mentor;Fostering;Funding;global health;Goals;Hepatitis B Infection;Hepatitis C virus;HIV;Individual;Infection;innovation;Interruption;Investments;Lead;Link;Malignant neoplasm of liver;Malignant Neoplasms;Medical;Mentors;Mentorship;Mission;next generation;Patients;peer;Peer Review;Pilot Projects;Play;Primary carcinoma of the liver cells;Process;programs;Publications;Qualifying;recruit;Research;Research Activity;Research Infrastructure;Research Personnel;Research Project Grants;Resources;Risk Factors;Role;Schistosoma mansonii infection;Senegal;senior faculty;skills;success;Talents;Training Activity;Training Programs;Uganda;Universities

PROJECT_TITLE: H2A Developmental Core


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Cardiovascular;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Heart Disease;Heart Disease - Coronary Heart Disease;Hypertension;Patient Safety;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health;Stroke;Telehealth

PI_NAMEs: CASILLAS, ALEJANDRA  (contact);TOWFIGHI, AMYTIS

PROJECT_TERMS: Accounting;Address;Adult;African American;Ambulatory Care;Asian Americans;Asian population;Awareness;Black Populations;Black race;Blood Pressure;blood pressure control;Blood Pressure Monitors;blood pressure reduction;cardiology service;cardiometabolism;cardiovascular health;cardiovascular risk factor;Cardiovascular system;Caring;chronic care model;Chronic Disease;Clinic;Clinical;Communities;Community Health Aides;community partnership;community-level factor;Complex;County;COVID-19 pandemic;Data;design;diet and exercise;digital health;Disease;Disparity;disparity reduction;Education;Education and Outreach;Educational Materials;Equity;ethnic disparity;ethnic diversity;ethnic minority population;Ethnic Origin;Ethnic Population;Event;experience;federal poverty level;Filipino American;Health;Health behavior;health care availability;health disparity;health equity;health literacy;Health Services;Health system;Healthcare Systems;High Prevalence;Hispanic;Home Blood Pressure Monitoring;Hospitals;Hypertension;improved;improved outcome;Income;Individual;innovation;Institutional Racism;Intervention;Latino;Latino Population;Limited English Proficiency;Linguistics;literacy;Los Angeles;Low income;low socioeconomic status;Mediator;medical specialties;medication compliance;Medication Management;Mexican Americans;mortality;multi-ethnic;multi-racial;Municipalities;Myocardial Infarction;Myocardial Ischemia;National Heart, Lung, and Blood Institute;Neurology;novel;operation;Participant;patient level intervention;patient portal;Patients;Pharmaceutical Preparations;Pharmacists;Population;post stroke;preventable death;Prevention trial;primary outcome;Primary Prevention;Public Health;Race;racial disparity;racial diversity;racial minority population;Randomized;randomized trial;Randomized, Controlled Trials;Recording of previous events;Recurrence;Research Personnel;Risk;Risk Reduction;safety net;Self Management;skills;social health determinants;socioeconomic disparity;Stroke;System;team-based care;Technology;telehealth;Testing;traditional care;treatment as usual;United States;video visit;vulnerable community;wireless fidelity

PROJECT_TITLE: BP REACH: Blood Pressure disparities Reduction, Equity, and Access among safety net patients with Cardiovascular Health risk


NIH_SPENDING_CATS: Cancer;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;HIV/AIDS;Hepatitis;Hepatitis - B;Infectious Diseases;Liver Cancer;Liver Disease;Prevention;Rare Diseases

PROJECT_TERMS: Acceleration;Advocate;AFP gene;Africa;Africa South of the Sahara;African;Age;Albumins;Antigens;antiretroviral therapy;Attenuated;Behavioral;Biological Markers;Birth;Cancer Etiology;CD4 Lymphocyte Count;cell injury;Cessation of life;Chronic Hepatitis B;chronic infection;Cirrhosis;Clinical;Clinical Research;co-infection;cohort;Country;Data;data quality;design;Development;Diagnostic;Dose;dosimetry;elastography;Eligibility Determination;Etiology;Fibrosis;Foundations;Funding;Genotype;Goals;Guidelines;Hepatitis B e Antigens;Hepatitis B Infection;Hepatitis B Surface Antigens;Hepatitis B Vaccines;Hepatitis B Virus;Hepatitis C virus;high risk;high risk population;HIV;HIV Infections;Human;Image;Incidence;Individual;Infection;insight;Interruption;Interview;Investigation;Liver Fibrosis;Malignant Neoplasms;Medical;Mentors;Monitor;Mutation;novel;novel marker;Outcome;Oxidative Stress;Oxidative Stress Pathway;Participant;Pathogenesis;Pathology;Patients;Persons;Population;Population Attributable Risks;Population Research;Prevention;Preventive vaccine;Primary carcinoma of the liver cells;Process;Prospective cohort;Questionnaires;recruit;Research;Research Infrastructure;Research Personnel;Resources;response;Risk;Risk Factors;RNA;Sampling;Schistosoma mansonii infection;screening;Senegal;Serum;Serum Albumin;sociodemographics;Standardization;study population;Tenofovir;Testing;Translational Research;treatment as prevention;Treatment Protocols;treatment response;Uganda;ultrasound;Universities;vaccine acceptance;Viral;viral DNA;virus core;Virus Diseases;Virus Replication;Visit;α-Fetoproteins

PROJECT_TITLE: Antiviral treatment as prevention for HBV- and HBV/HIV-associated hepatocellular carcinoma


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Rare Diseases;Tuberculosis

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Public Health Relevance Statement: Tuberculosis (TB) is now the leading infectious disease threat in the world, killing more people than HIV/AIDS, as reported today by the World Health Organization. The TB RAMP program at UCSF is a collaboration between the School of Medicine, Institute for Global Health Sciences, and Curry International TB Center all of UCSF; the UC Berkeley School of Public Health; and the Center for Infectious Diseases in the California Department of Public Health. The program seeks to catalyze the development of research scientists focused on TB and on addressing the NIAID Strategic Plan for TB Research. This program is committed to developing scholars at the early stage of their careers by offering innovative training on TB disease, access to research opportunities, provision of sustained mentorship, and support for pilot projects to launch their research careers. TB RAMP scholars will be inspired, well trained, and mentored to pursue high quality and innovative research focused on combatting the TB epidemic.

PI_NAMEs: FAIR, ELIZABETH  (contact);NAHID, PAYAM

PROGRAM_OFFICER_NAME: MOITRA, KAROBI

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Africa;Americas;Area;Asia;Award;Basic Science;Biomedical Research;California;career;Caring;Cause of Death;Clinical;Clinical Research;Collaborations;Communicable Diseases;Communication;Creativeness;Data;design;Discipline;Discipline of Nursing;Disease;Education;education research;Educational Curriculum;Enrollment;Epidemic;epidemiology study;experience;Faculty;Funding;Funding Mechanisms;Funding Opportunities;Genomics;global health;Goals;Grant;health economics;Health Sciences;HIV;HIV/AIDS;Immunology;implementation science;Infectious disease threat;innovation;interest;International;Knowledge;Laboratories;Link;medical schools;Medicine;meetings;Mentors;Mentorship;Methodology;Mission;National Institute of Allergy and Infectious Disease;Online Systems;Ownership;Peer Review;Persons;Pharmacy facility;Philippines;Pilot Projects;Policies;Politics;Postdoctoral Fellow;Program Sustainability;programs;Protocols documentation;Public Health;public health relevance;Public Health Schools;Pulmonology;Reporting;Research;research and development;Research Infrastructure;Research Methodology;Research Personnel;Research Project Grants;Resource Allocation;Resources;San Francisco;Scholars Program;Science;science education;Scientist;Site;skill acquisition;skills;Strategic Planning;Structure;Systems Biology;Technology;Training;Translational Research;translational research program;Travel;Tuberculosis;Uganda;United Nations;United States National Institutes of Health;Universities;Vietnam;World Health Organization

PROJECT_TITLE: TB Research And Mentorship Program (TB RAMP)


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Breast Cancer;Cancer;Immunotherapy;Nanotechnology;Women's Health Research

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Narrative This proposal builds on a strong portfolio of data demonstrating potent efficacy of a plant virus nanoparticle immunotherapy to launch adaptive, systemic, and durable antitumor immunity. In this continued research, we propose to develop immuno-combination and targeted therapies for treatment of triple negative breast cancer, which is an aggressive life-threatening disease with poor prognosis. Efficacy and mechanism of action will be studied in mouse models and canine patients with breast cancer.

PI_NAMEs: STEINMETZ, NICOLE FRANZISKA (contact)

PROGRAM_OFFICER_NAME: HARRIS, RAYMOND D

PROJECT_TERMS: 4T1;anti-PD-L1;Binding;Biodistribution;Biological Assay;biophysical properties;Blocking Antibodies;Blood;Breast Cancer Patient;cancer immunotherapy;candidate identification;candidate selection;Canis familiaris;carcinogenesis;Cells;checkpoint therapy;chemotherapy;Clinical;Clinical Trials;Combined Modality Therapy;companion animal;Cowpea Mosaic Viruses;Data;Development;Disease;Disseminated Malignant Neoplasm;Distant Metastasis;Dose;Drug Delivery Systems;effector T cell;efficacy evaluation;Engineering;Event;Extracellular Matrix;Female;Flow Cytometry;Funding;Future;Genomics;Goals;Human;Immune;Immune checkpoint inhibitor;immune modulating agents;Immune system;Immunologics;immunoregulation;Immunotherapy;in situ vaccination;In Vitro;in vivo;Inflammation;Innate Immune System;insight;Intravenous;Libraries;Life;Link;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Neoplasms;Molecular;Monitor;Monoclonal Antibodies;mouse model;Myelogenous;nanodrug;nanomedicine;nanoparticle;neoantigens;Neoplasm Metastasis;pathogen;Patients;Pattern;Pattern recognition receptor;Peptides;personalized approach;pharmacologic;Pharmacology;Plant Viruses;preclinical development;prevent;Prognosis;programmed cell death ligand 1;Property;Proteins;Radiation;receptor;Recurrence;Research;residence;Resources;S100A9 gene;Safety;safety assessment;Schedule;Signal Transduction;Site;Spain;Specificity;synergism;T-Lymphocyte;targeted treatment;Testing;Time;Tissues;TLR2 gene;Toll-like receptors;Toxic effect;treatment response;triple-negative invasive breast carcinoma;tumor;Tumor Antigens;tumor growth;Tumor Immunity;Tumor Markers;tumor microenvironment;tumorigenesis;Virus-like particle

PROJECT_TITLE: Dual-pronged nano-drug delivery using plant virus-like particles

STUDY_SECTION: NANO

STUDY_SECTION_NAME: Nanotechnology Study Section[NANO]


NIH_SPENDING_CATS: Cancer;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;HIV/AIDS;Hepatitis;Hepatitis - B;Infectious Diseases;Liver Cancer;Liver Disease;Rare Diseases;Vector-Borne Diseases

PI_NAMEs: THOMAS, DAVID L (contact)

PROJECT_TERMS: Advocate;Affect;Africa;Africa South of the Sahara;African;Aftercare;Age;Animal Model;Antigens;Cancer Etiology;carcinogenicity;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Chronic;Chronic Care;Chronic Hepatitis B;chronic infection;Circulation;Clinical;Collaborations;Country;cytokine;Data;DNA Double Strand Break;egg;Eligibility Determination;Genes;Genetic;Goals;HBV Genotype;Hepatic;Hepatitis B Infection;Hepatitis B Surface Antigens;Hepatitis B Virus;Hepatitis C virus;Hepatocyte;HIV;HIV Infections;Human;Human Herpesvirus 4;Human Herpesvirus 8;Human Papillomavirus;Immune response;Immunity;Immunologics;Immunology;improved;In Vitro;Income;Infection;Inflammation;Inflammatory;inflammatory milieu;insight;Interruption;Investigation;JUN gene;Light;Liver;liver biopsy;Macrophage;Malignant Neoplasms;Measures;Medical;Mentors;Mesentery;mortality;novel;Oncogenes;Oncogenic;Pathway interactions;Patients;Persons;Physiological;Plasma;Praziquantel;Primary carcinoma of the liver cells;Proto-Oncogenes;Public Health;Research;Residual state;response;Risk;Risk Factors;Schistosoma mansoni;Schistosoma mansonii infection;Senegal;Site;standard of care;System;T cell response;Testing;Time;Tissues;Treatment Efficacy;Uganda;Universities;Venous;viral DNA;Virus Diseases;Virus Replication

PROJECT_TITLE: Interaction of Schistosomiasis mansoni and hepatitis B virus infections on hepatocellular carcinoma


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Neurosciences

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Narrative Virtually all pharmacology studies are based on quantifying responses to drugs in a population of patients, thereby obscuring fundamental individual differences in drug responses. This proposal ushers in the era of personalized medicine to anesthesiology by developing a novel set of parameters that define anesthetic responses in each subject individually. By correlating individual features of responses to anesthetics with degree of decrement in cognitive performance across life span, we will identify unique individual features of anesthetic responses that may confer greater vulnerability to post-operative delirium and cognitive dysfunction that plagues millions of elderly adults who undergo surgical procedures annually.

PI_NAMEs: KELZ, MAX  (contact)

PROGRAM_OFFICER_NAME: JUSTINOVA, ZUZANA

PROJECT_TERMS: Address;Adult;Affect;Age;Age Months;age related changes;Aging;Anesthesia procedures;Anesthesiology;Anesthetics;Animals;Arousal;Attention;behavior test;Characteristics;Clinical;Cognition;cognitive function;cognitive performance;cognitive recovery;cognitive testing;cohort;Conscious;Control Animal;cost;Data;Delirium;Dependence;Dependovirus;designer receptors exclusively activated by designer drugs;Development;Dose;Drug resistance;drug sensitivity;drug standard;Drug usage;Elderly;Enterobacteria phage P1 Cre recombinase;Exhibits;Exposure to;Genetic;human old age (65+);Human Volunteers;hypocretin;Impaired cognition;Impairment;improved;inattention;Inbred Mouse;Individual;Individual Differences;innovation;inter-individual variation;Investigation;Isoflurane;life span;Link;Longitudinal Studies;Measures;Mediating;Methodology;Mus;Neurobiology;Neurons;novel;old mice;older patient;Operative Surgical Procedures;Pathway interactions;patient population;Patients;Performance;personalized medicine;Pharmaceutical Preparations;Pharmacology;Pharmacology Study;Population;population based;Population Study;Postoperative Complications;postoperative delirium;precision drugs;promoter;Publishing;Recording of previous events;Recovery;Reflex action;Reproducibility;Resistance;response;restoration;Role;selective expression;Sleep;Speed;sustained attention;Testing;Time;Transfection;Transgenic Mice;virtual;Wakefulness

PROJECT_TITLE: Personalized Anesthetic Pharmacology Across the Lifespan

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Eye Disease and Disorders of Vision;Nanotechnology;Pain Research

ORG_CITY: WEST LAFAYETTE

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: PROJECT NARRATIVE Ocular drug delivery is challenging due to the complex structure of the cornea that impedes adequate drug delivery and therapeutic efficacy. This project aims to develop a minimally-invasive, painless, and effective ocular drug delivery platform through the innovation of fully-miniaturized and slowly-biodegradable (over days) silicon nanoneedles built upon a rapidly-dissolvable (within 30 seconds) water-soluble contact lens. This platform can yield a more controllable and longer-lasting drug release profile in a less-invasive manner compared to current gold-standard biodegradable microneedles, thus improving therapeutic efficacy.

PI_NAMEs: LEE, CHI HWAN  (contact);PAULUS, YANNIS MANTAS

PROGRAM_OFFICER_NAME: GOVER, TONY DOUGLAS

PROJECT_TERMS: Address;Affinity;Anti-Inflammatory Agents;Area;base;Binding;biomaterial compatibility;Blindness;Blood Vessels;Blurred vision;cell injury;chemical conjugate;Chemistry;Choroidal Neovascularization;Chronic;Clinical;clinical implementation;clinical practice;Complex;Contact Lenses;Cornea;Corneal Neovascularization;crystallinity;Custom;design;Development;Disease;Dose;Drainage procedure;Drops;Drug Compounding;Drug Delivery Systems;drug release profile;Dry Eye Syndromes;Effectiveness;Engineering;Extravasation;Eye;Eye diseases;Eyedrops;Fluorescein Angiography;Growth;Histology;Hour;Human;Immunohistochemistry;improved;In Vitro;in vivo;in vivo evaluation;in vivo Model;Infection;Inflammation;innovation;Invaded;Keratoplasty;Kinetics;Lasers;limbal;Liquid substance;Low-Level Laser Therapy;Mechanics;miniaturize;minimally invasive;Modeling;Morphology;nanofabrication;nanomaterials;nanoneedle;nanoscale;Nature;Needles;Operative Surgical Procedures;Oryctolagus cuniculus;Pain;Painless;Patients;Performance;Persons;Pharmaceutical Preparations;Photography;Polymers;Porosity;Property;prototype;Radial;Research;Retina;Risk;Risk Factors;Shapes;side effect;Silicon;standard care;stem cells;Structure;Surface;Surgical sutures;Techniques;technology platform;Testing;Therapeutic;Time;Tissues;tool;Translating;Trauma;Treatment Efficacy;Validation;Vascular Endothelial Growth Factors;Visual;Water;water solubility

PROJECT_TITLE: Development of Nanoneedle Array for Painless and Long-Term Sustained Intraocular Drug Delivery


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Hypertension;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: BODEN-ALBALA, BERNADETTE MARIE (contact)

PROJECT_TERMS: Achievement;Address;Adult;Advocacy;Affect;American Heart Association;Area;behavior change;Behavior Therapy;Behavioral;Biological Process;Black Populations;Blood Pressure;Blood Pressure Monitors;blood pressure reduction;Blood Vessels;California;cardiometabolism;Cardiovascular Diseases;cardiovascular disorder prevention;cardiovascular disorder risk;cardiovascular health;cardiovascular risk factor;Cause of Death;Cessation of life;Child;clinically significant;Color;Communication;Communities;community based participatory research;community engagement;Community Health;Community Health Aides;community intervention;Cost Savings;County;Data;Development;disability;Disparity;disparity gap;Economics;Education;Effectiveness;efficacy evaluation;efficacy testing;empowerment;Equity;ethnic disparity;Ethnic Population;Event;Family;family structure;Growth;Health;health equity;heart disease risk;Heart Diseases;Household;Hypertension;hypertension prevention;improved;Individual;Intervention;Latino;Latino Population;Learning;Life;Life Style;Link;Measures;Modeling;mortality;multi-ethnic;Multilingualism;Myocardial Infarction;novel;Oranges;Participant;Patients;Physical environment;Population;Population Heterogeneity;prevent;Prevention;prevention effectiveness;Prevention strategy;Primary Prevention;programs;Provider;provider communication;Psychological reinforcement;Race;racial disparity;Randomized, Controlled Trials;reinforced behavior;Research;residential segregation;Risk;Risk Factors;risk perception;Risk Reduction;Self Efficacy;Shapes;skills;social;social capital;social determinants;social movement;Social Network;Social Processes;social structure;socioeconomic disparity;socioeconomics;Stroke;support network;technological innovation;Testing;Translating;treatment adherence;treatment as usual;Underserved Population;Vascular Diseases;Vietnamese;web portal;Work;young adult;Youth

PROJECT_TITLE: UCLA-UCI Center for Eliminating Cardio-Metabolic Disparities in Multi-Ethnic Populations


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE The U.S. social safety net provides little financial assistance to most patients following illness, and financial toxicity after acute illness is poorly measured and understood. The SARS-CoV-2 (COVID-19) pandemic has created millions of new survivors of acute illness in the U.S., making it even more urgent that we develop new ways to measure financial toxicity. The overarching goal of this proposal is to 1) use novel data to better measure objective financial burden, 2) use rigorous empirical methods to estimate the effect of COVID-19 infection on financial burden and explore heterogeneity of effects across different groups of patients, and 3) create a COVID-19-specific measure of subjective financial distress, with the ultimate goal of informing the creation of policies to better protect vulnerable patients from the financial consequences of illness.

PI_NAMEs: BECKER, NORA V. (contact)

PROGRAM_OFFICER_NAME: WILLIS, TAMARA

PROJECT_TITLE: The cost of illness: The impact of COVID-19 on patient financial outcomes

STUDY_SECTION: HCRT

STUDY_SECTION_NAME: Healthcare Research Training [HCRT]


ORG_CITY: PORTLAND

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Project Narrative Sepsis remains a surprisingly common and underappreciated suddenly developing and life-threatening disease condition that can lead to death within hours to days, even with the most advanced medical treatment, including powerful antibiotics and organ support systems. While there remains a critical and unmet medical and societal need to develop a safe and effective treatment for sepsis, numerous attempts and failed drugs in a large number of clinical trials of the past keeps discouraging the pharma industry from investing in sepsis research and development. Despite failures of the past, we remain optimistic and propose to continue intensive and improved search for a medical solution to sepsis through identification of novel mechanisms and drug targets that detrimentally contribute to the poor prognosis and high mortality of the disease, and, if successful, promote the evaluation and development of fundamentally new attempts to prevent or combat sepsis with fundamentally new medicines.

PI_NAMEs: LUPU, FLOREA ;MCCARTY, OWEN J (contact)

PROGRAM_OFFICER_NAME: HUNTLEY, CLAYTON C

PROJECT_TERMS: Acute Respiratory Distress Syndrome;Adverse event;Animals;anti-microbial drug;Antibiotic Therapy;Antibiotics;Antibodies;Antibody Affinity;antibody inhibitor;Attenuated;Bacteremia;Bacterial Infections;Bacterial Model;bacterial resistance;Binding;Blood Coagulation Disorders;Blood Platelets;Blood Vessels;Bradykinin;Cardiopulmonary;Cardiovascular system;Caring;Cause of Death;Cessation of life;Clinical;Clinical Trials;Coagulation Process;combat;Complement;Complement Activation;complement C5b;Complement Factor H;Complex;Consumption;Contact Inhibition;cytokine release syndrome;Data;design;Development;Disease;Disease Progression;Disseminated Intravascular Coagulation;Dose;drug development;drug market;Drug Targeting;druggable target;Edema;effective therapy;Endothelial Cells;Endothelial Plasminogen Activator Inhibitors;Enzymes;Escherichia coli;Evaluation;Event;Exposure to;Factor XII;Failure;FDA approved;Feedback;Fibrinolysis;Functional disorder;Generations;Genetic;Goals;granulocyte;healthy volunteer;Hemodialysis;Hemorrhage;Hospitals;Hour;Hypotension;Immune response;improved;In Vitro;in vivo;Industry;Infection;infection risk;Inflammation;Inflammatory;Inflammatory Response;Infusion procedures;inhibitor;Intervention;Investments;Kallikrein-Kinin System;Kininogens;Life;Medical;Medicine;microbial;Modeling;Molecular;molecular dynamics;Molecular Target;Morbidity - disease rate;mortality;multiorgan damage;Multiple Organ Failure;Mus;nonhuman primate;novel;Organ;Organ failure;organ growth;Outcome;Papio;pathogen;Pathogenesis;pathogenic bacteria;Pathologic;Patients;Perfusion;Pharmaceutical Preparations;pharmacologic;phase I trial;Phase II Clinical Trials;Play;Prekallikrein;Prevalence;prevent;Primates;Prognosis;Research;research and development;Research Project Grants;response;Role;Sepsis;Septic Shock;Shock;Solid;Staphylococcus aureus;Support System;Syndrome;System;Systemic infection;Testing;Therapeutic;Thrombin;Thrombosis;Tissues;Translating;translational potential;Vascular Diseases;Virulent

PROJECT_TITLE: Contact Activation and Infection

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-VH-C(02)M]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Heart Disease;Maternal Health;Maternal Morbidity and Mortality;Rare Diseases;Women's Health Research

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE Peripartum cardiomyopathy (PPCM) remains a major cause of maternal morbidity and mortality. Inhibition of prolactin with the dopamine agonist bromocriptine appeared to improve outcomes in previous clinical studies of PPCM; however, no randomized trial has been performed in a multi-racial North American cohort comparing bromocriptine against standard heart failure therapy. The purpose of the Randomized Evaluation of Bromocriptine Therapy for Peripartum Cardiomyopathy (REBIRTH) trial is to evaluate whether the addition of bromocriptine to standard heart failure therapy improves outcomes in women with PPCM.

PI_NAMEs: ABEBE, KALEAB Z (contact)

PROGRAM_OFFICER_NAME: DESVIGNE-NICKENS, PATRICE

PROJECT_TERMS: Africa;African Women;American;biobank;Biological Markers;Breast Feeding;Bromocriptine;Cathepsins;Cessation of life;clinical center;Clinical Data;Clinical Research;Clinical Trials;cohort;Collaborations;Complex;Congestive Heart Failure;Core Facility;Country;Data Coordinating Center;data dissemination;data management;design;Development;Dopamine Agonists;Echocardiography;European;Evaluation;Exclusion;German population;Guidelines;Heart failure;Heart Transplantation;Hospitalization;improved;improved outcome;Investigation;Left;Left Ventricular Ejection Fraction;Maintenance;maternal morbidity;Maternal Mortality;mortality;multi-ethnic;Multi-Institutional Clinical Trial;multi-racial;Myocardial;Newly Diagnosed;North America;Online Systems;Outcome;Pathogenesis;peripartum cardiomyopathy;Phase;placebo group;Placebos;Postpartum Period;Predictive Value;primary endpoint;programs;Prolactin;protocol development;Randomized;randomized placebo controlled trial;randomized trial;Randomized, Controlled Trials;Recommendation;Recovery;Reporting;Research Personnel;secondary endpoint;South African;Statistical Data Interpretation;Suggestion;System;Systems Analysis;Therapeutic;Time;Treatment Failure;treatment group;trial comparing;United States;Universities;Woman;women's outcomes;working group

PROJECT_TITLE: (2/2) Randomized Evaluation of Bromocriptine In Myocardial Recovery THerapy for Peripartum Cardiomyopathy (REBIRTH)

STUDY_SECTION: CLTR

STUDY_SECTION_NAME: Clinical Trials Review Study Section[CLTR(JA)]


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Hypertension;Neurosciences

ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: PROJECT NARRATIVE Electroacupuncture works by stimulating various nerves in the body, which can lead to lowering of blood pressure. In this study, we are looking at how a specific combination of nerve stimulation using electroacupuncture can improve the function of the arterial vessels that control blood pressure. Findings from this study may aid the design and delivery of electroacupuncture treatment to help those who are unable to get to their blood pressure to target levels.

PI_NAMEs: MALIK, SHAISTA  (contact);TJEN-A-LOOI, STEPHANIE CHEE-YEE

PROGRAM_OFFICER_NAME: CHEN, WEN G

PROJECT_TERMS: Acupuncture Points;Acupuncture Therapy;Address;Age;Aging;alpha-bungarotoxin receptor;Animals;Anti-Hypertensive Agents;Anti-Inflammatory Agents;Area;Autonomic Dysfunction;Autonomic nervous system;Biological Markers;Blood Pressure;blood pressure control;blood pressure reduction;Blood Vessels;Brain Stem;Cardiovascular Diseases;cardiovascular risk factor;Cell Nucleus;Central Nervous System;Chronic;Clinical;Clinical Research;Clinical Trials;Complex;conventional therapy;cytokine;Data;design;Development;Diagnosis;Dorsal;dorsal motor nucleus;Drops;Effectiveness;Electroacupuncture;Equilibrium;experience;functional improvement;Goals;heart rate variability;Human;human old age (65+);Hypertension;hypertension control;hypertensive;Hypothalamic structure;immune function;Immune system;improved;indexing;Inflammation;Inflammation Mediators;Inflammatory;Maps;Measures;Mediating;Methods;mind/body;modifiable risk;National Center for Complementary and Integrative Health;Nerve;neural;Neural Pathways;Neuroanatomy;neurobiological mechanism;Neuroimmunomodulation;Neurons;neurophysiology;neuroregulation;Neurosecretory Systems;Outcome;paraventricular nucleus;Participant;Pathway interactions;Patients;Peripheral;peroneal nerve;Phenotype;Physiological;Qualifying;randomized, controlled study;Rattus;receptor;Regulation;Research;response;salt sensitive;Science;somatosensory;Structure of tibial nerve;study population;System;Therapeutic;Therapeutic Effect;Translating;Work;World Health Organization

PROJECT_TITLE: Neuroimmune mechanisms underlying electroacupuncture effect on vascular function

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CVRS-K(02)]


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Digestive Diseases;Infectious Diseases;Liver Disease;Malaria;Orphan Drug;Primary Immunodeficiencies;Rare Diseases;Vector-Borne Diseases

ORG_CITY: ATHENS

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF GEORGIA

ORG_STATE: GA

PHR: PROJECT NARRATIVE This proposal is to optimize a new series of drugs to eradicate the dormant liver stage of Plasmodium vivax. Our team will use the results of a novel liver stage culturesystem to drive the optimization of. the new drugs and will use chemical biology tools to identify targets for the drugs. The impact of this work could be the first new drug to treat relapsing malaria in over 70 years and the identification of the first validated targets for new drug discovery for P. vivax.

PI_NAMEs: KYLE, DENNIS E (contact);MANETSCH, ROMAN

PROGRAM_OFFICER_NAME: MO, ANNIE X  Y

PROJECT_TERMS: Aminoquinolines;analog;asexual;Back;Biological Assay;Biological Availability;Biological Models;Biology;Bite;Blood;Chemicals;Country;Culicidae;Culture Techniques;Data;Development;Disease;Drug Combinations;drug discovery;Drug Screening;Drug Targeting;early screening;Erythrocytes;Evaluation;Evolution;Glucose;Glucosephosphate Dehydrogenase Deficiency;Goals;Harvest;Hemolysis;Hepatocyte;high throughput screening;Homologous Gene;Human;Image;improved;In Vitro;in vitro activity;in vitro Model;Infection;Invaded;Ionophores;Knowledge;Label;Lead;lead optimization;lead series;Liver;Malaria;Metabolic;Metabolic Marker;Metabolism;Methods;Modeling;new therapeutic target;nonhuman primate;novel;novel therapeutics;Patients;Persons;Pharmaceutical Chemistry;Pharmaceutical Preparations;Plasmodium falciparum;Plasmodium ovale;Plasmodium vivax;Primaquine;Property;Publishing;pyridine;quinoline;Relapse;Resistance;Series;Sporozoites;System;Time;tool;transmission process;Validation;Vivax Malaria;Work

PROJECT_TITLE: Lead optimization and target identification of drugs targeting hypnozoites

STUDY_SECTION: DDR

STUDY_SECTION_NAME: Drug Discovery and Mechanisms of Antimicrobial Resistance Study Section[DDR]


ORG_DEPT: BIOCHEMISTRY

PHR: Project Narrative  Cancer remains a major cause of human mortality and morbidity despite significant advances in diagnosis and treatment. This training program is designed to develop the next generation of independent cancer research scientists by providing them with essential fundamental knowledge, laboratory research skills, and leadership abilities needed to contribute to new discoveries in the prevention, early detection and treatment of cancer.

PI_NAMEs: MATUNIS, MICHAEL J.;WEERARATNA, ASHANI T (contact)

PROGRAM_OFFICER_NAME: LIM, SUSAN E

PROJECT_TERMS: anti-cancer research;Area;Training

PROJECT_TITLE: Training in Areas Fundamental to Cancer Research

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Cancer;Genetics;Prevention

ORG_NAME: ROCKEFELLER UNIVERSITY

PHR: Narrative Metastatic disease is the primary cause of death for most cancer patients. We will study how hereditary genetic differences can cause or prevent cancer metastasis. Mechanistic studies of the molecules involved in metastasis formation can aid the development of more effective therapies.

PI_NAMEs: TAVAZOIE, SOHAIL F. (contact)

PROGRAM_OFFICER_NAME: GRIL, BRUNILDE M

PROJECT_TERMS: Apolipoprotein E;Award;Biology;Blood Vessels;breast cancer metastasis;Cancer Patient;Cause of Death;Cells;Cessation of life;Clinical Trials;colorectal cancer metastasis;Critical Pathways;Data;Development;Disease;driver mutation;effective therapy;Event;Genes;Genetic;Genetic Models;Genetic screening method;genetic variant;Germ-Line Mutation;Glycoproteins;Human;Immune;Immunotherapy;Inherited;innovation;insight;Laboratory Study;Malignant Neoplasms;Mediating;Melanoma;MicroRNAs;Molecular;mouse model;Mus;Neoplasm Metastasis;Optics;Patients;Physiological;prevent;Prevention;Process;response;reverse genetics;Signal Transduction;Solid;standard of care;targeted treatment;Therapeutic;translational potential;tumor

PROJECT_TITLE: Biology and genetics of metastatic disease


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Cancer;Brain Disorders;Cancer;Nanotechnology;Neurosciences;Radiation Oncology;Rare Diseases

ORG_CITY: TEMPE

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

PHR: Project Narrative Aggressive types of brain tumors (such as glioblastoma multiforme or GBM) respond poorly to the current treatments of surgery, radiotherapy, and chemotherapy. This research proposes to solve this challenge with a multifunctional magnetic nanoparticle agent that simultaneously delivers contrast for a novel bio-imaging technique called magnetic particle imaging (MPI), as well as magnetothermal therapy of the inoperable deep brain tumors. Sensitive and selective image-guided ablation of tumor is possible because these optimized nanoparticles only accumulate in the brain tumor tissue, and we envision that this two-armed approach may have utility with many other types of solid tumors such as pancreatic, lung and prostate.

PI_NAMEs: ARAMI, HAMED  (contact)

PROGRAM_OFFICER_NAME: AVULA, LEELA RANI

PROJECT_TERMS: 3-Dimensional;Adjuvant;Animal Model;Autopsy;Biodistribution;bioimaging;Biological;biomaterial compatibility;Biomedical Engineering;biomedical imaging;Blood - brain barrier anatomy;Brain;Brain Glioblastoma;Brain Neoplasms;Brain region;brain tissue;brain tumor imaging;Cancer Biology;cancer imaging;career;career development;Chemoresistance;chemotherapy;Chemotherapy and/or radiation;Chlorotoxin;Chronic Kidney Failure;Clinic;clinical application;contrast imaging;Contrast Media;cost effective;Data;design;dosage;Dose;Excision;experience;FDA approved;Focused Ultrasound Therapy;Gadolinium;Generations;Glioblastoma;Goals;Growth;Heating;high resolution imaging;Human;Image;image guided;image guided therapy;Imaging Device;imaging study;Imaging Techniques;Implant;implantation;improved;Injections;intravenous administration;intravenous injection;Iron;iron oxide nanoparticle;Knowledge;Link;Liver;Location;Lung;Magnetic nanoparticles;Magnetic Resonance Imaging;Magnetism;Malignant - descriptor;Malignant neoplasm of brain;Malignant Neoplasms;medical schools;Mentors;meter;Methods;millimeter;Modeling;Monitor;mortality;multidisciplinary;Mus;nanomaterials;nanomedicine;nanoparticle;Nanotechnology;neural implant;neuroimaging;Neurology;neuropathology;neurosurgery;novel;Operative Surgical Procedures;Organ;Ovarian;Pancreas;particle;Pathology;Patients;Penetration;Peptides;Positron-Emission Tomography;Primary Brain Neoplasms;Program Development;programs;Property;Prostate;Publishing;Radiation therapy;radioresistant;radiotracer;Recurrence;Relaxation;Renal clearance function;Research;research and development;Research Personnel;Resistance;Resolution;response;Safety;Scientist;Signal Transduction;Site;Solid Neoplasm;Spleen;subcutaneous;superparamagnetism;Survival Rate;targeted imaging;Techniques;Therapeutic;therapy resistant;Three-Dimensional Imaging;Tissues;tool;Training;tumor;tumor ablation;Tumor Cell Line;tumor microenvironment;Tumor Tissue;tumor xenograft;Unresectable;uptake

PROJECT_TITLE: Magnetic Particle Imaging (MPI) for Imaging and Magnetothermal Therapy of Brain Tumors

STUDY_SECTION_NAME: Transition to Independence Study Section (I)[NCI-I]


ORG_CITY: SAN ANTONIO

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

PHR: PROJECT NARRATIVE. Epigenetics of the autoantibody response in systemic lupus Epigenetic marks “interact” with genetic programs to regulate B cell functions, such as immunoglobulin (antibody) gene class switch DNA recombination (CSR), somatic hypermutation (SHM) and plasma cell differentiation, thereby informing the antibody response. Dysregulation of epigenetic mechanisms in B lymphocytes can result in aberrant autoantibody responses and would compound genetic susceptibility to mediate autoimmunity, including systemic lupus erythematosus (SLE), in which heavily mutated and class-switched (mainly IgG) autoantibodies produce widespread tissue and organ injury. This proposal addresses antibody and autoantibody responses in SLE and underlying mechanisms, with a focus on how Tet2, an important epigenetic factor, upregulates the expression of AID, which is essential for CSR/SHM, and Blimp-1, which is essential for plasma cell differentiation. It will also address how the expression and activity of Tet2 is regulated at different differentiation stages of human and mouse B cells, by estrogen, which underpins the female bias for systemic autoantibody-mediated autoimmunity, such as in SLE. In additional to this hormonal stimulus, this proposal will address the role nutritional and metabolic elements in Tet2 induction/activation, thereby providing the basis for the development of Tet2 inhibitors as therapeutics in autoimmune diseases. Our innovative and rigorous experiments will unveil novel and targetable epigenetic mechanisms that integrate environmental cues to inform lupus autoantibody responses.

PI_NAMEs: CASALI, PAOLO  (contact)

PROGRAM_OFFICER_NAME: RICE, JEFFREY S

PROJECT_TERMS: Ablation;activation-induced cytidine deaminase;Address;Affinity;alpha ketoglutarate;analog;Antibodies;Antibody Response;Ascorbic Acid;ATAC-seq;Attention;Autoantibodies;Autoimmune Diseases;Autoimmunity;B cell differentiation;B-Cell Activation;B-Lymphocytes;Bacteria;Binding;bisulfite;Butyrates;Cell Physiology;Cells;Chemosensitization;ChIP-seq;Cues;cytokine;Data;demethylation;Development;differentiation in vitro;Disproportionately impacts women;DNA;DNA analysis;Down-Regulation;Elements;Enhancers;Epigenetic Process;epigenetic regulation;epigenome;Estrogens;experience;experimental study;Female;Fumarates;Gene Expression;Gene Modified;Genes;Genetic;Genetic Predisposition to Disease;Genetic Recombination;Genetic Transcription;genomic locus;glycosylation;Histone Deacetylase;histone modification;Histones;Homologous Gene;Hormonal;Human;Hydroxyl Radical;Immunize;Immunoglobulin Class Switching;Immunoglobulin G;Immunoglobulin Somatic Hypermutation;Immunoglobulins;Impairment;inhibitor;innovation;Knock-in;Knock-in Mouse;Left;Ligands;Link;Lupus;Mediating;Mediator;Memory;Metabolic;MicroRNAs;Molecular;mouse model;Mus;mutant;Mutate;neutralizing antibody;novel;Nutritional;organ injury;pathogenic autoantibodies;Patients;Phosphorylation;Plasma;plasma cell differentiation;Plasma Cells;posttranscriptional;PRDM1 gene;Pristane;Prodrugs;programs;Proteins;recruit;Regulation;response;Rest;Role;SIRT1 gene;small molecule;Stimulus;Systemic Lupus Erythematosus;Systems Biology;T-Lymphocyte;Testing;Therapeutic;therapeutic target;tissue injury;TNFSF5 gene;tool;Transcript;transcription factor;Untranslated RNA;Up-Regulation;Viral;Virus;Vitamin A;Vitamins