ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Cannabidiol Research;Cannabinoid Research;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Natural Products;Substance Misuse

ORG_CITY: Boulder

ORG_NAME: UNIVERSITY OF COLORADO

ORG_STATE: CO

PHR: Project Narrative The overarching goal of this proposal is to conduct a placebo-controlled randomized trial comparing the effects of hemp-derived CBD with and without THC, relative to placebo, on reducing cannabis use and CUD symptoms in adult treatment seeking cannabis concentrate users with CUD. This question has enormous public health importance because the field lacks an effective CUD medication, particularly for high potency concentrate users. In addition, hemp-derived CBD products with and without low levels of THC are already widely available to consumers; thus, a positive finding would have an immediate public health impact.

PI_NAMEs: BIDWELL, L. CINNAMON (contact)

PROGRAM_OFFICER_NAME: WANG, JIA BEI

PROJECT_TERMS: Abstinence;Acute;Adult;Affective;affective disturbance;Anxiety;Blood;Cannabidiol;Cannabinoids;Cannabis;cannabis seeking;CNR1 gene;CNR2 gene;Creatinine;Data;Double-Blind Method;drug reward;DSM-V;effective therapy;Flowers;Goals;Hemp;high risk;high risk population;Intervention;Intoxication;Laboratories;marijuana legalization;marijuana use;marijuana use disorder;marijuana user;Marketing;Measures;Mediating;medication compliance;Methods;Monitor;negative affect;Participant;Patient Self-Report;Pharmaceutical Preparations;physical symptom;Physiological;Placebo Control;placebo controlled trial;Placebos;Preparation;primary outcome;Protocols documentation;psychologic;Public Health;Randomized;randomized placebo controlled trial;Randomized, Controlled Trials;Recreation;recruit;Research;Standardization;Symptoms;telehealth;Testing;Tetrahydrocannabinol;THC concentration;THC exposure;trial comparing;United States;Urine;week trial;Withdrawal;Withdrawal Symptom

PROJECT_TITLE: Hemp-derived Cannabidiol for the treatment of cannabis use disorder in concentrate users: A double-blind placebo-controlled randomized trial

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


ADMINISTERING_IC: MD

ARRA_FUNDED: N

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: NASHVILLE

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: TENNESSEE STATE UNIVERSITY

ORG_STATE: TN

PHR: Engaging Partners in Caring Communities (EPICC) is a community-engaged research (CEnR) project designed to support delivery of evidence-based health promotion programs in churches serving African American communities, and engaging participants in collectively identifying and addressing social determinants of health. It incorporates a survey completed by members of churches to identify facilitators and challenges of program implementation, and technical assistance guided by the results of the survey provided by a research team that includes a community member.

PI_NAMEs: ALEXANDER, LEAH R;GISHE, JEMAL ;SELOVE, REBECCA  (contact)

PROGRAM_OFFICER_NAME: MUJURU, PRISCAH

PROJECT_TERMS: Address;Affect;African American;African American population;analytical tool;Black church;Cardiovascular Diseases;Chronic;Church;Cluster randomized trial;Collaborations;Communities;community academic partnership;community collaboration;community empowerment;community engaged research;community engagement;Community Healthcare;Community of Practice;community organizations;community partners;community research;Community Surveys;Consolidated Framework for Implementation Research;design;Development;Diabetes Mellitus;Education;Elements;evidence base;Evidence based program;experience;Faculty;Faith;Faith-based organization;General Hospitals;Goals;graduate student;Health;health determinants;health disparity;health equity;health equity promotion;Health Promotion;Historically Black Colleges and Universities;Hospitals;Hypertension;implementation science;improved;Individual;innovation;insight;Intervention;Lead;Leadership;Learning;Link;Malignant Neoplasms;medical schools;member;Methods;multidisciplinary;Obesity;Online Systems;Participant;patient engagement;poor health outcome;Population;programs;Reduce health disparities;Research;Research Personnel;Research Project Grants;Risk;safety net;skills;Social Change;social health determinants;Social Network;Social Policies;social structure;Spirituality;Structure;Surveys;Technology;Tennessee;Testing;tool;Trust;undergraduate student;Universities;web site;Work

PROJECT_TITLE: Engaging Partners in Caring Communities (EPICC): Building capacity to implement health promotion programs in African American churches


ADMINISTERING_IC: HG

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: SAINT LOUIS

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE  The human genome encodes tens of thousands of circular RNAs (circRNAs), of which the translation is essential for regulating important biological functions, such as cell proliferation, differentiation, and migration. Current technologies cannot distinguish circRNAs from linear RNAs efficiently, such that the mechanism and molecular components regulating circRNA translation remain unclear. The proposed research will utilize my newly developed technology, which can identify the RNA sequences that initiate circRNA translation specifically, to (i) characterize the sequence and protein components regulating circRNA translation, (ii) elucidate the association between genetic variation, circRNA translation and disease, and (iii) build a gene expression platform with tunable expression level and tissue specificity.

PI_NAMEs: CHEN, CHUN-KAN  (contact)

PROGRAM_OFFICER_NAME: SEN, SHURJO KUMAR

PROJECT_TERMS: Basic Science;Biological Assay;Biological Process;Biology;Blood;Cell Line;Cell Proliferation;Cells;circular RNA;Clinical;Complement;computer program;convolutional neural network;CRISPR interference;deep learning;Disease;Elements;Environment;Foundations;Gene Expression;Genetic Variation;Genomic Segment;Head;Human;Human Genome;Injections;insight;Institution;Internal Ribosome Entry Site;Libraries;Liver;Lung;Malignant Neoplasms;Mass Spectrum Analysis;Mediating;medical schools;Mentorship;Methods;migration;Molecular;mRNA Precursor;Mus;Neoplasm Metastasis;new technology;Oligonucleotides;Pilot Projects;Positioning Attribute;Postdoctoral Fellow;Proteins;Records;Regulation;Regulatory Element;Reporter;Research;Research Personnel;Resources;RNA;RNA Sequences;Role;Science;screening;Sensitivity and Specificity;Single Nucleotide Polymorphism;single-cell RNA sequencing;skills;Sorting;Specificity;Spliceosomes;success;System;Tail;Technology;technology development;Tissue-Specific Gene Expression;Tissues;tool;Training;Transcript;transduction efficiency;Translation Initiation;Translational Regulation;Translational Research;Translations;tumorigenesis;Universities;Viral;Work

PROJECT_TITLE: Systematic identification of RNA sequences and protein components regulating circular RNA translation

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: HOUSTON

ORG_NAME: METHODIST HOSPITAL RESEARCH INSTITUTE

ORG_STATE: TX

PHR: PROJECT NARRATIVE Metastatic bladder cancer is a devastating disease with a 5-year survival rate of only 5.4%. While the initial steps of the metastatic cascade are rather well defined, identification of targets to block this process continues to be a major clinical challenge. Discovering the regulatory mechanisms by which the metastatic microenvironment support tumor cell colonization and survival will enable design of new strategies not only targeting the primary tumors, but also eradicating metastatic foci – a potential new breakthrough.

PI_NAMEs: CHAN, KEITH SYSON  (contact)

PROGRAM_OFFICER_NAME: SNYDERWINE, ELIZABETH G

PROJECT_TERMS: Address;Binding;Bioinformatics;Biological Process;Bladder Carcinoma;Bladder Neoplasm;bladder transitional cell carcinoma;C-terminal;cancer cell;cancer type;Categories;Cell Nucleus;Cell secretion;Cells;Cessation of life;ChIP-seq;Clinical;clinical translation;Clustered Regularly Interspaced Short Palindromic Repeats;Collagen;Collagen Receptors;Communication;Conceptions;Data;design;Disease;Disease Management;Distal;DNA Binding;Ectopic Expression;Extracellular Matrix;Family;Fibroblasts;Funding;gamma secretase;Genes;Goals;Image;in vivo;innovation;Invaded;Investigation;Kininogenase;Knock-out;Knowledge;lead candidate;Ligands;Luciferases;Lung;Malignant Epithelial Cell;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Mediating;Metastatic Neoplasm to the Lung;metastatic process;migration;Modality;Mutate;N-terminal;Nature;Neoplasm Metastasis;neoplastic cell;notch protein;novel;novel strategies;Nuclear;Nuclear Translocation;overexpression;Pattern;Peptide Hydrolases;pharmacologic;Phenotype;Phosphorylation;Phosphorylation Site;Pilot Projects;Play;precision medicine;Primary Neoplasm;Process;Progression-Free Survivals;Property;Protein Fragment;Proteins;receptor;Receptor Activation;Receptor Signaling;Regulation;respiratory smooth muscle;Role;scaffold;Signal Transduction;Site;Smooth Muscle Myocytes;Specific qualifier value;src Homology Region 2 Domain;success;Survival Rate;Testing;Therapeutic Intervention;therapeutic target;tumor;tumor microenvironment;Tumor Volume;Tyrosine Phosphorylation;Tyrosine Phosphorylation Site

PROJECT_TITLE: Distinct Tumor and Metastatic Collagen Microenvironments: Divergent Targeting Approaches

STUDY_SECTION: TME

STUDY_SECTION_NAME: Tumor Microenvironment Study Section[TME]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Genetics;HIV/AIDS;Hematology;Hodgkin's Disease;Human Genome;Infectious Diseases;Lymphatic Research;Lymphoma;Rare Diseases

ORG_CITY: BALTIMORE

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE This project seeks to study EBV gene regulation and the relationship between the EBV epigenome and EBV and cellular transcriptome in EBV(+) lymphoma in the setting of HIV. The study will also characterize EBV methylation in cfDNA from plasma and saliva in order to define and develop novel EBV diagnostics for HIV-associated lymphoma. 1

PI_NAMEs: AMBINDER, RICHARD FREDERICK (contact);XIAN, RENA

PROGRAM_OFFICER_NAME: LIDDELL HUPPI, REBECCA

PROJECT_TERMS: Age;AIDS-Related Lymphoma;Autopsy;Baltimore;Biological Assay;bisulfite sequencing;Burkitt Lymphoma;Cause of Death;CD4 Lymphocyte Count;cell free DNA;Chicago;cohort;cost;Data;design;Development;Diagnosis;Diagnostic;DNA;DNA analysis;DNA Markers;DNA Methylation;Epigenetic Process;epigenome;Epstein-Barr Virus latency;Epstein-Barr Virus-Related Lymphoma;Epstein-Barr Virus-Related Malignant Neoplasm;Evaluation;Future;Gene Expression;Gene Expression Profile;Gene Expression Regulation;Genes;health care availability;HIV;Hodgkin Disease;Human Herpesvirus 4;improved;Investigation;large cell Diffuse non-Hodgkin's lymphoma;Large-Cell Immunoblastic Lymphoma;latent infection;liquid biopsy;low and middle-income countries;lymphoblastoid cell line;Lymphoma;Malignant neoplasm of nasopharynx;Malignant Neoplasms;Methylation;methylation pattern;methylome;Modeling;Modification;novel;Organ;Pathway interactions;Patients;Pattern;Persons;Plasma;Plasma Cells;point of care;Population;Prevalence;primary effusion lymphoma;rapid test;Saliva;sample collection;Sampling;screening;Screening for cancer;sex;Source;Specificity;System;Testing;Training;transcriptome;transcriptome sequencing;tumor;Validation;Viral;Viral Genes;Viral Genome;Virus Latency

PROJECT_TITLE: Investigating the EBV methylome in PLWH: Discovery and Development of Novel EBV Diagnostics in Plasma and Saliva


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Neurosciences;Opioid Misuse and Addiction;Opioids;Pain Research;Pediatric;Prescription Drug Misuse;Prevention;Sleep Research;Substance Misuse

ORG_CITY: STANFORD

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: PROJECT NARRATIVE The proposed research has significant public health relevance related to the adolescent opioid epidemic because it will identify modifiable factors associated with the development of opioid misuse among adolescents who receive an opioid prescription for pain management following surgery. This research will examine sleep deficiency as a novel risk factor associated with problematic opioid use behaviors and explore underlying mechanisms related to pain and psychological risk factors. The application’s contribution would be significant because it is expected to enable the identification of adolescents at risk for problematic opioid use following surgery and inform novel behavioral therapeutic targets for the prevention of opioid misuse.

PI_NAMEs: GROENEWALD, CORNELIUS BOTHA (contact)

PROGRAM_OFFICER_NAME: LAPOSKY, AARON D

PROJECT_TERMS: actigraphy;Acute;Acute pain management;Address;Adolescent;Adolescent Development;adolescent patient;Affect;Athletic Injuries;Behavior;Behavior Therapy;Behavioral;Behavioral Mechanisms;Clinical Trials;critical period;Data;Development;Dose;Ecological momentary assessment;Electronics;Exposure to;Family;follow up assessment;Future;innovation;Intervention;Knowledge;machine learning algorithm;Measures;Mediating;Mediation;Medical;Mental Depression;Methodology;Methods;Modernization;modifiable risk;Monitor;Moods;multimodality;novel;Observational Study;Operative Surgical Procedures;Opioid;opioid epidemic;opioid misuse;opioid use;opioid use disorder;Orthopedic Surgery;Overdose;Pain;Pain intensity;Pain management;Participant;Pathway interactions;Patient Self-Report;peer;Perioperative;Pharmaceutical Preparations;Pilot Projects;poor sleep;predictive modeling;prescription opioid;prescription opioid misuse;Prevention;Process;prospective;psychologic;Psychological Factors;psychological symptom;psychosocial;Public Health;public health relevance;Recording of previous events;Reporting;Research;response;Risk;Risk Factors;Sleep;Sleep Deprivation;Sleep Disorders;sleep quality;substance use;Surgical Injuries;Surveys;Technology;Testing;therapeutic target;Time;United States;Youth

PROJECT_TITLE: Sleep deficiency and opioid use/misuse in adolescents following surgery

STUDY_SECTION: BMHO

STUDY_SECTION_NAME: Biobehavioral Medicine and Health Outcomes Study Section[BMHO]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Biotechnology;Cancer;Gene Therapy;Genetics;Immunotherapy;Orphan Drug;Rare Diseases

ORG_CITY: FORT COLLINS

ORG_DEPT: OTHER CLINICAL SCIENCES

ORG_NAME: COLORADO STATE UNIVERSITY

PHR: Project Narrative CAR-T cells have demonstrated value in the treatment of hematological malignancies, though their efficacy in solid tumors is lacking. This proposal will establish an outbred, immunocompetent canine model of CAR-T therapy for solid tumors to identify molecular predictors of CAR-T cell homing and persistence in tumors. This model will be used for to evaluate novel CAR-T therapy approaches prior to human trials.

PI_NAMEs: BRILL, SAMUEL  (contact)

PROGRAM_OFFICER_NAME: ADAMS, GREGORY

PROJECT_TERMS: Animal Model;Animals;Antibodies;Antigens;antitumor effect;B lymphoid malignancy;B-Cell Lymphomas;Back;Bar Codes;Binding;Biology;Biopsy;Breast Carcinoma;Cancer Biology;canine model;Canis familiaris;CAR T cell therapy;career;CD28 gene;Cell Physiology;Cells;Cellular biology;Cellular immunotherapy;cellular transduction;Chemicals;chimeric antigen receptor;chimeric antigen receptor T cells;Chimeric Proteins;Coculture Techniques;Complement;complement system;Contracts;cost;design;Disease remission;doctoral student;driving force;efficacy evaluation;Engraftment;Enzyme-Linked Immunosorbent Assay;Ethics;Evolution;Fc Receptor;Functional disorder;Future;Generations;Genetic;Health;Hematologic Neoplasms;Home;Human;Immune;Immune system;Immunocompetent;immunodeficiency;Immunodeficient Mouse;In Vitro;in vivo;in vivo imaging system;Inbreeding;Incidence;Individual;Infusion procedures;Interferon Type II;Interleukin-2;Kinetics;Lentivirus Vector;Malignant Neoplasms;Measurement;Measures;Melanoma;Methods;Modeling;Molecular;mouse model;MS4A1 gene;Mus;Neuroblastoma;novel;novel strategies;Nucleotides;Osteosarcoma;Patients;Phenotype;pre-clinical;preclinical efficacy;Procedures;Production;Receptor Signaling;Refractory;Relapse;Research;restraint;Sampling;Scientist;single cell sequencing;Solid Neoplasm;success;T cell infiltration;T-Cell Homing Receptors;T-Cell Receptor;T-Lymphocyte;T-Lymphocyte Subsets;Testing;timeline;trafficking;Training;transcriptome sequencing;Translating;translational model;Treatment Efficacy;tumor;Tumor Antigens;Tumor Cell Line;tumor growth;Veterinarians;Video Microscopy;Xenograft Model

PROJECT_TITLE: Dogs as a high fidelity, high throughput model to evaluate CAR-T cell function and dysfunction


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_CITY: TALLAHASSEE

ORG_DEPT: PSYCHOLOGY

ORG_NAME: FLORIDA STATE UNIVERSITY

ORG_STATE: FL

PHR: Project Narrative Successful uptake of research in authentic school and community settings requires the application of well- established, team-based, systematic approaches to translational science that combines research findings, stakeholder engagement, both quantitative and qualitative analyses, and iterative improvements. These approaches have great potential to close the research to practice gap by creating sustainable processes built for the contexts in which they will be used. With this LDRC, we expand upon previous successes to include studies beyond foundational science and with more diverse populations of students.

PI_NAMEs: HART, SARA ANN;HOGAN, TIFFANY P;PATTON-TERRY, NICOLE SANDI (contact);SOLARI, EMILY J.

PROGRAM_OFFICER_NAME: MILLER, BRETT

PROJECT_TERMS: Acceleration;Address;Applied Research;Basic Science;career;Child;Classification;Cognitive;Communities;community engagement;community setting;Complex;Country;Data;data management;Disability research;Early identification;Early treatment;Environmental Risk Factor;Equity;Evidence based practice;Florida;Genetic;Goals;high risk;implementation science;improved;innovation;Instruction;Intervention;Knowledge;Language;Language Disorders;Leadership;Learning;Learning Disabilities;Linguistics;Location;marginalized community;marginalized population;member;Methodology;Modeling;multidisciplinary;Neighborhoods;next generation;Oral;Participant;Patient-Focused Outcomes;Population;Population Heterogeneity;Process;Process Assessment;psychologic;Public Health;Race;Reading;reading comprehension;recruit;Research;Research Institute;Research Personnel;Research Project Grants;research to practice;resilience factor;Risk;Risk Factors;risk prediction;Role;Sampling;Schools;Science;screening;skills;socioeconomics;Structure;Students;success;System;Training;Training Activity;Translational Research;Translations;Underrepresented Populations;uptake;Voice;Vulnerable Populations;Woman;Work

PROJECT_TITLE: Learning Disabilities Translational Science Collective: Building on the Florida LDRC


NIH_SPENDING_CATS: Behavioral and Social Science;Disability Research;Pediatric

PI_NAMEs: HART, SARA ANN (contact)

PROJECT_TITLE: Administrative Core


PI_NAMEs: PATTON-TERRY, NICOLE SANDI (contact)

PROJECT_TERMS: Advocate;base;career;Caregivers;Collaborations;Communication;Communities;community engagement;Creativeness;data management;Decision Making;Development Plans;Disability research;Dissemination and Implementation;Ensure;Equity;equity, diversity, and inclusion;evidence base;Family;Florida;Health;Human Resources;Individual;Institution;interest;Interest Group;Knowledge;Language disability;Leadership;Learning;Learning Disabilities;marginalized community;marginalized population;member;Mentors;Mentorship;Modeling;Monitor;Oral;Outcome;Patient-Focused Outcomes;peer;Policy Maker;Population;Printed Media;Process;Publications;Reading;Reading Disabilities;Research;Research Institute;Research Personnel;Research Project Grants;Resources;Role;Science;skills;social media;Structure;symposium;Technology;tool;Training;Translating;Translational Research;Translations;undergraduate student;Universities

PROJECT_TITLE: Engagement Core


NIH_SPENDING_CATS: Disability Research;Pediatric

PI_NAMEs: SCHATSCHNEIDER, CHRIS W (contact)

PROJECT_TERMS: career;Child Development;Communication;Communities;Complex;Data;Data Analyses;Data Analytics;Data Collection;data management;Data Management Resources;data repository;data sharing;design;Disability research;Drops;Environment;Environmental Exposure;experience;flexibility;Florida;Goals;Guidelines;Hour;indexing;interdisciplinary collaboration;Investigation;Leadership;Learning Disabilities;Location;Measures;Medical;member;Mentorship;Methods;Names;open data;Play;Policies;Practice Management;Process;programs;Protocols documentation;Research;Research Design;Research Personnel;Research Project Grants;Resources;Role;Science;Services;sharing platform;Site;social;Source;Statistical Data Interpretation;Statistical Models;System;Testing;theories;tool;Training;Translational Research;United States National Institutes of Health;virtual;Work

PROJECT_TITLE: Data Management Core


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Disability Research;Mental Health;Pediatric

PI_NAMEs: WAGNER, RICHARD K (contact)

PROJECT_TERMS: Achievement;Address;Affect;Applied Research;Basic Science;Child;Classification;Cognitive;Comprehension;comprehension deficit;Data;Development;Early identification;Educational Assessment;effective intervention;eighth grade;executive function;experience;Face;Failure;Family;Florida;fourth grade;Frequencies;Future;Goals;Health;Impairment;improved;Individual;Instruction;interest;Intervention;Knowledge;Language;Language Disorders;Learning Disabilities;Learning Disorders;Literature;Measurement;Minor;Modeling;National Institute of Child Health and Human Development;Nature;Occupations;Oral;Participant;Policies;Population;Prevalence;Process;Public Health;Reader;Reading;reading comprehension;Research;response;Risk;risk prediction;risk prediction model;School Drop-Outs;Schools;Self-Help Devices;Severities;skills;spelling;Statistical Models;Student Dropouts;Students;success;Testing;Theoretical model;Translational Research;Underemployment;United States

PROJECT_TITLE: Project 1: Advances in classification and identification for specific learning disorders in reading (T1)


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Genetics;Human Genome;Mental Health;Pediatric;Prevention

PROJECT_TERMS: Achievement;Address;Attention deficit hyperactivity disorder;Behavioral;career;Child;Classification;Cognitive;Communities;community advisory board;community-centered;cost effective;Data;data resource;disability;disease classification;DNA sequencing;Education;educational atmosphere;efficacy testing;English Learner;Environment;first grade;Florida;Focus Groups;Funding;Genes;Genetic;Genetic Markers;genome sequencing;Genomics;Geographic Information Systems;Geographic Locations;Goals;Growth;high risk;Home;improved;Individual;Individual Differences;Inequity;Instruction;Intervention;Language;Language Development;Learning;Learning Disabilities;Learning Disorders;Measures;member;Methods;Monitor;Mutation;Neighborhoods;next generation;Outcome;Participant;predicting response;Predictive Factor;predictive modeling;protective factors;psychologic;Psychological Factors;Psychology;public database;Reading;reading comprehension;reading difficulties;recruit;Research;Research Personnel;Resource Allocation;response;Risk;Risk Factors;Role;Sampling;Schools;Science;screening;second grade;Single Nucleotide Polymorphism;skill acquisition;skills;Students;Survey Methodology;Surveys;System;technology platform;theories;Time;training opportunity;Translational Research;Variant;whole genome;Work

PROJECT_TITLE: Project 2: Using Precision Education Factors to Individualize Education (T2)


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cardiovascular;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: CHICAGO

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: Project Narrative This project leverages the unprecedented opportunity to utilize existing data in the All of Us Researcher Workbench, our prior linkage of environmental factors into the dataset, and novel analytic methods to investigate how the social context and physical environment jointly contributes to disparities in CVD risk, and to further evaluate the impact of individual-level factors (e.g., established genes, individual demographics) on the modification and/or mitigation of these impacts. It addresses the need for integrated, and comprehensive investigation of the multiple layers of environmental influence with individual-level factors, especially in studies powered to investigate racial/ethnic disparities in CVD. It builds upon work being conducted by the University of Chicago team using All of Us data and provides an excellent training opportunity for a Disparities Fellow.

PI_NAMEs: ASCHEBROOK-KILFOY, BRISEIS A (contact)

PROGRAM_OFFICER_NAME: PRICE, CANDICE

PROJECT_TERMS: Address;Air Pollution;All of Us Research Program;American;analytical method;Animals;Area;Asthma;Behavior;Biomedical Research;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;Categories;Characteristics;Chicago;Chronic Disease;cohort;Communities;community partners;Community Surveys;Complex;coping;Data;Data Set;demographics;deprivation;disease disparity;Disease Outcome;disorder risk;Disparity;Environmental Hazards;Environmental Impact;environmental justice;Environmental Risk Factor;ethnic disparity;Factor Analysis;fine particles;Genes;GSTM1 gene;GSTP1 gene;GSTT1 gene;Health;health disparity;Illinois;Impairment;Individual;insight;interest;Investigation;Joints;Knowledge;Link;Literature;Low income;Measurement;Methods;minority communities;Mission;Modeling;Modification;Morbidity - disease rate;mortality;neighborhood association;Neighborhoods;novel;novel strategies;Participant;Persons;Physical environment;Population;Population Heterogeneity;precision medicine;Prevalence;protective factors;Publishing;racial disparity;Research;Research Personnel;Resources;Risk;Risk Factors;Role;Science;Site;social determinants;Social Environment;social influence;stroke risk;Sum;Training;training opportunity;United States National Aeronautics and Space Administration;Universities;Weight;Work;working group

PROJECT_TITLE: Investigation of the social context and physical environment on cardiovascular disease disparities in the All of Us Research Program


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Disability Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Social Determinants of Health

PI_NAMEs: HOGAN, TIFFANY P (contact)

PROJECT_TERMS: Address;base;Child;Classification;Clinical Research;Communities;community engagement;community partners;Comprehension;Data;Development;disability;disadvantaged background;economic disparity;efficacy study;efficacy trial;efficacy/implementation trial;Eligibility Determination;Emotional;Ensure;Ethnic Origin;Ethnic Population;Evaluation;evidence base;Evidence based practice;flexibility;Florida;Future;Geographic Distribution;Geographic Locations;Goals;Household;Hybrids;implementation evaluation;implementation facilitators;implementation science;implementation strategy;implementation study;improved;interest;Knowledge;Language;learning community;Learning Difficulty;Learning Disabilities;Linguistics;Low income;marginalized community;marginalized population;meetings;Methodology;Minority Groups;Monitor;Oral;Outcome;Phase;Population Heterogeneity;Population Study;Poverty;pre-clinical;Prevention;Process;prototype;Public Health;Qualifying;Race;racial population;Reading;Research;research to practice;Resource-limited setting;Resources;Risk;Rural;Schools;Science;screening;Services;Site;Students;success;Support System;System;Testing;translational pipeline;Translational Research;Underachievement;uptake;usability;Work

PROJECT_TITLE: Project 3  Engaging Educators around Classification Systems in Schools (T3)


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Prevention;Social Determinants of Health

PI_NAMEs: SOLARI, EMILY J. (contact)

PROJECT_TERMS: Address;Adoption;Behavioral;Black race;Characteristics;Child;Child Welfare;Classification;Cognitive;Communities;community-level factor;Comprehension;contextual factors;Crime;Data;Data Set;Development;Diagnosis;disability;Disability status;Dyslexia;Early identification;Early Intervention;early screening;Education;efficacy evaluation;English Learner;Ensure;ethnic identity;evidence base;Expenditure;Family;Florida;Focus Groups;Funding;Geography;Health;improved;Individual;Instruction;Knowledge;Language;Learning Disabilities;literacy;longitudinal analysis;low socioeconomic status;Measurement;Methods;Modeling;Nature;Neighborhoods;Oral;Population;Poverty;predictive modeling;Preventive;processing speed;Public Health;Race;Reading;reading ability;reading comprehension;Reading Disabilities;remediation;Reporting;Research;Research Personnel;resilience;Resources;Risk;Risk Marker;risk prediction;Rural Population;Sampling;Schools;screening;skills;Smoking;Students;Subgroup;Surveys;System;teacher;Testing;Time;Translational Research;Underserved Population;Universities;uptake;Violence;Virginia;Work

PROJECT_TITLE: Project 4- Population level language and literacy screening: An early warning system for word and language related reading disabilities (T4)


ADMINISTERING_IC: HS

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: MINNEAPOLIS

ORG_NAME: HENNEPIN HEALTHCARE RESEARCH INSTITUTE

ORG_STATE: MN

PHR: Project Narrative The AHRQ-sponsored conference series on “Developing a research agenda for wellness within the LHS framework” has an overarching goal of creating a foundation for development of the next generation of healthcare worker (HCW) wellness scholars and equipping them with tools to carry out a structured research agenda on HCW reactions to challenging work environments. These conferences will convene a multidisciplinary group of stakeholders studying HCW wellness and work culture. Our objectives are to identify promising strategies to study HCW wellness and develop competencies required for this rigorous area of scholarship.

PI_NAMEs: LINZER, MARK  (contact)

PROGRAM_OFFICER_NAME: GRIFFIOEN, MARI

PROJECT_TITLE: Research Conference to develop a national healthcare workforce wellness research agenda for AHRQ in the Learning Health System (LHS) program

STUDY_SECTION: HEOR

STUDY_SECTION_NAME: Healthcare Effectiveness and Outcomes Research[HEOR]


ADMINISTERING_IC: GM

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Natural Products

ORG_CITY: Peoria

ORG_NAME: MIDWEST BIOPROCESSING CENTER, LLC

PHR: Project Narrative  This project is aimed toward the development of a production platform for natural 6-deoxysugars. These deoxysugars can be used to make derivatives of natural products with new or improved therapeutic properties, for example, more potent anticancer agents and antibiotics that are effective against antibiotic-resistant bacteria.

PI_NAMEs: TURNER, ROBERT J. (contact)

PROGRAM_OFFICER_NAME: ASLAN, KADIR

PROJECT_TERMS: Academia;Acids;Address;Amino Sugars;anti-cancer therapeutic;Antibiotics;Antineoplastic Agents;Bacterial Antibiotic Resistance;bioactive natural products;Biological;bioprocess;Cells;chemical synthesis;commercialization;Deoxy Sugars;Derivation procedure;Development;Enhancers;Enzymes;Escherichia coli;Feasibility Studies;Formulation;Fucose;Genes;Glucose;Glycoengineering;Glycosides;glycosylation;Goals;Growth;Hexoses;Hydrolysis;improved;in vivo;Individual;Industry;innovation;interest;maltose-binding protein;manufacture;Methods;microbial;Microbial natural product;Midwestern United States;Modeling;Modification;natural product derivative;Natural Products;Nature;novel;novel strategies;novel therapeutics;Nucleosides;Pathway interactions;Phase;Plants;Plasmids;Play;Preparation;Process;Production;Property;Protocols documentation;research and development;Research Personnel;Role;Sales;secondary metabolite;Solubility;sugar;System;Therapeutic;Work

PROJECT_TITLE: Production of Natural Deoxysugars for Use in Chemical Synthesis of Glycosides


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Attention Deficit Hyperactivity Disorder (ADHD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Neurosciences;Pediatric

ORG_CITY: BOSTON

ORG_DEPT: CHEMISTRY

ORG_NAME: NORTHEASTERN UNIVERSITY

ORG_STATE: MA

PHR: PROJECT NARRATIVE The proposed research is relevant to public health in that it aims to achieve greater understanding of, and creation of more effective, cognitive interventions for typically developing adolescents as well as youth diagnosed with Attention-Deficit Hyperactivity Disorder (ADHD). This research is aligned with the NIMH mission of transforming the understanding and treatment of mental illnesses in that it seeks to develop and test an accessible and low-cost intervention to improve cognitive function and mental health in diverse populations using an innovative telemedicine approach. The proposed research cuts across the bounds of numerous NIH agencies, with our framework contributing to the missions of the NIMH, NICHD, NIA, NCI, NEI, NIAAA, NINCD, NIDA, and NINDS, in that all of these agencies work with populations who can gain direct benefits from successful approaches to remediate cognitive deficits and improve mental health, and the NIH’s greater mission to seek knowledge that will result in enhanced health and a reduced burden of disabilities, and ultimately, transform mental health care.

PI_NAMEs: JAEGGI, SUSANNE M;SEITZ, AARON R (contact)

PROGRAM_OFFICER_NAME: GARVEY, MARJORIE ANN

PROJECT_TERMS: Address;Adherence;Adolescent;Adoption;Adult;Age;age group;assessment application;Attention deficit hyperactivity disorder;Back;Basic Science;Binding;Brain Injuries;Characteristics;Child;Cognition;Cognitive;Cognitive deficits;cognitive function;Cognitive remediation;cognitive training;Complex;Data;Data Set;data sharing;design;Development;Diagnosis;digital treatment;disability burden;Disease;executive function;Health;Human;improved;Individual;Individual Differences;innovation;Intervention;intervention cost;Knowledge;Learning;life span;Literature;Marketing;Mediating;Mediator;Mental disorders;Mental Health;Mental Health Services;Methods;Mission;National Institute of Child Health and Human Development;National Institute of Drug Abuse;National Institute of Mental Health;National Institute of Neurological Disorders and Stroke;National Institute on Alcohol Abuse and Alcoholism;older adult;open data;Outcome;Outcome Measure;Participant;Pattern;Performance;Personal Satisfaction;Pharmacological Treatment;Population;Population Heterogeneity;power analysis;programs;Public Health;Randomized;recruit;Reproducibility;Research;Schools;Scientist;sex;Short-Term Memory;Societies;Software Tools;Telemedicine;Testing;Time;Training;United States National Institutes of Health;Validity and Reliability;Work;Youth

PROJECT_TITLE: Understanding Mediating and Moderating Factors that Determine Transfer of Working Memory Training

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BP-N(02)M]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Behavioral and Social Science;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Mental Health;Pediatric;Precision Medicine;Prevention

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

PHR: Project Narrative The proposed research is relevant to public health because it makes new discoveries about diseases and conditions associated with speech-language disorders; and identifies shared genetic risk factors underlying speech-language outcomes and a host of other clinical outcomes. Findings from this study will establish necessary groundwork for improving precision medicine for individuals with speech-language disorders by identifying novel clinical and genetic risk factors; generating testable hypotheses about disease mechanisms; and early intervention efforts for comorbid conditions. This project is therefore relevant to the NIH’s mission to gain insights into the nature and behavior of living systems and to apply this knowledge to reduce illness and disability.

PI_NAMEs: NAYAK, SRISHTI  (contact)

PROGRAM_OFFICER_NAME: STORKEL, HOLLY LYNN

PROJECT_TERMS: Acceleration;Accounting;African American population;All of Us Research Program;Articulation;autism spectrum disorder;Awareness;Behavior;biobank;bioinformatics tool;Biomedical Research;Clinical;clinical phenotype;clinical risk;Code;Cognitive;Collection;Communication;Communication impairment;Communities;comorbidity;Complex;Data;Databases;Development;developmental disease;Developmental Stuttering;Diagnosis;disability;Disease;Disease Outcome;diverse data;Early Intervention;Early treatment;Education;Electronic Health Record;Epidemiology;Gene Expression;Generations;Genetic;Genetic Predisposition to Disease;Genetic Risk;genetic risk factor;genetic variant;genome wide association study;genome-wide;genomic data;Genomics;Health;health equity;health inequalities;Human Genetics;ICD-9;improved;Individual;Individual Differences;insight;Intervention;Knowledge;Language;Language Development;Language Development Disorders;Language Disorders;language impairment;language outcome;Language Pathology;Laws;Learning Disabilities;Link;machine learning algorithm;Maps;Measures;Medical;medical examination;Mental disorders;Mental Health;Mission;multidisciplinary;National Institute on Deafness and Other Communication Disorders;Nature;Neurodegenerative Disorders;novel;Organism;Outcome;Participant;Personal Satisfaction;Persons;phenome;Phenotype;physical conditioning;polygenic risk score;Population;population health;portability;precision medicine;Predisposition;Public Health;Research;resilience;resilience factor;Rest;Risk;Risk Factors;Risk Marker;risk prediction;Speech;spelling;Stuttering;Symptoms;Techniques;Testing;trait;transcriptome;United States National Institutes of Health;Work

PROJECT_TITLE: Investigating the medical phenome of speech-language traits:  risk, resilience, and opportunities for intervention


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Genetics;Immunotherapy;Lung;Lung Cancer;Orphan Drug;Precision Medicine;Prevention;Radiation Oncology;Rare Diseases;Tobacco;Tobacco Smoke and Health

ORG_CITY: PITTSBURGH

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Head and neck cancer has the sixth highest incidence among cancers worldwide, and recurrence rates approach 50% in patients diagnosed with locally advanced disease. In this proposal, we will utilize cutting-edge mouse models of oral cavity cancer to study mechanisms of tumor progression and resistance to standard therapies. We will also use these models to identify and test new therapeutic approaches. Therefore, the proposed research is particularly relevant to the National Institute of Dental and Craniofacial Resesarch’s mission to improve oral health by enhancing the understanding and treatment of head and neck cancer.

PI_NAMEs: MOWERY, YVONNE MARIE (contact)

PROGRAM_OFFICER_NAME: THIRUMANGALATHU, SHOBA

PROJECT_TERMS: Address;advanced disease;Affect;anti-PD1 therapy;Antigen Presentation;Award;bench to bedside;Cancer Biology;cancer cell;Cancer Model;cancer therapy;Cancer Therapy Evaluation Program;Carcinogens;career;career development;Characteristics;chemoradiation;Cisplatin;Clinical;Clinical Trials;clinically relevant;Combined Modality Therapy;Competence;craniofacial;Credentialing;Data Analyses;Dental;design;Development;Diagnosis;Disease;Distant;DNA Damage;DNA Sequence Alteration;Dose;Epigenetic Process;Evaluation;Exposure to;FAT gene;Gene Mutation;Genetic Induction;Genetic study;Genetically Engineered Mouse;Genomics;Goals;Grant;Head and Neck Cancer;head and neck cancer patient;Head and Neck Squamous Cell Carcinoma;High-Throughput Nucleotide Sequencing;HPV negative;HPV oropharyngeal cancer;HPV-negative head and neck cancer;Human;Human papilloma virus infection;image guided radiation therapy;immune cell infiltrate;immune checkpoint;immune checkpoint blockade;Immune system;Immunocompetent;Immunodeficient Mouse;Immunologic Surveillance;improved;improved outcome;in vivo Model;Incidence;inhibitor;innovation;irradiation;Isogenic transplantation;Knowledge;Laboratories;Leadership;Lesion;Local Therapy;malignant mouth neoplasm;Malignant Neoplasms;Mentorship;Mission;Modeling;Molecular;mouse model;Mus;Mutate;Mutation;Neoplasm Metastasis;Neoplasm Transplantation;new therapeutic target;novel;novel strategies;novel therapeutic intervention;novel therapeutics;Oral health;Outcome;Pathway interactions;Patient-Focused Outcomes;Patients;pembrolizumab;Phase;Phase II Clinical Trials;Phosphotransferases;Physicians;PIK3CA gene;Platinum;pre-clinical;Pre-Clinical Model;preclinical study;Preparation;Prognosis;programmed cell death protein 1;programs;Proteins;radiation resistance;radiation response;Radiation therapy;Radiosensitization;Recurrence;Recurrent disease;Refractory Disease;Research;Resistance;response;Risk Factors;Safety;Scientist;Signal Pathway;skills;standard of care;Structure;T-Lymphocyte;Techniques;Testing;Therapeutic;therapy resistant;Time;Tobacco;Tobacco use;Tobacco-Associated Carcinogen;Training;Translating;transplant model;treatment optimization;treatment strategy;tumor;Tumor Biology;tumor heterogeneity;tumor initiation;tumor microenvironment;tumor progression;Writing;Xenograft procedure

PROJECT_TITLE: Employing Novel Primary Mouse Models of Head and Neck Cancer to Overcome Chemoradiation Resistance

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: AMHERST

ORG_DEPT: PHYSIOLOGY

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

ORG_STATE: NY

PHR: PROJECT NARRATIVE Coordinated activity among different regions of the neocortex is essential for normal sensory perception, cognition, and motor control. My research will focus on the mechanisms by which the visual thalamus mediates functional communication between visual cortical areas through the transthalamic corticocortical circuit. This project will provide insight into core mechanisms of functional communication between visual cortical areas, interactions that are impaired by both diseases affecting visual perception (e.g. schizophrenia) and brain injuries affecting visually guided behavior (e.g. visuo-spatial neglect following trauma).

PI_NAMEs: NESKE, GARRETT  (contact)

PROGRAM_OFFICER_NAME: FLANDERS, MARTHA C

PROJECT_TERMS: Address;Advisory Committees;Affect;Anatomy;Animals;Architecture;Area;Arousal;awake;Axon;Behavior;Behavioral;Biological Models;Brain Injuries;Calcium;Cells;Characteristics;Cognition;Communication;Dependence;Detection;Disease;Electrophysiology (science);experimental study;extracellular;Feedback;Foundations;Functional disorder;Future;Genetic;Goals;Image;Impairment;In Vitro;in vivo;insight;Investigation;Label;Laser Scanning Microscopy;Lateral;Lateral posterior nucleus of thalamus;Learning;Link;Literature;Maps;Medial;Mediating;microscopic imaging;Monitor;motor control;Mus;neglect;Neocortex;neocortical;Nervous System Disorder;Neurons;neuropsychiatric disorder;novel;optogenetics;Output;Pathologic;Pathway interactions;Perception;Phase;Play;Population;Positioning Attribute;post-doctoral training;Preparation;Presynaptic Terminals;Property;Research;Research Personnel;Research Proposals;response;Role;Schizophrenia;Secondary to;Sensory;Shapes;Slice;Synapses;Synaptic Transmission;Techniques;Testing;Thalamic Nuclei;Thalamic structure;Training;Trauma;two-photon;V2 neuron;Visual;Visual Cortex;Visual evoked cortical potential;Visual Pathways;Visual Perception;visual processing;visual stimulus;Visual System;Visuospatial;Work

PROJECT_TITLE: Roles of higher-order visual thalamus in state-dependent corticocortical communication


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Bioengineering;Climate-Related Exposures and Conditions;Health Effects of Indoor Air Pollution;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: SEATTLE

ORG_NAME: SPECTREE INC.

ORG_STATE: WA

PHR: Project Narrative  Exposure to complex environmental agents, such as ultrafine particulate matter derived from combustion sources and engineered nanomaterials, is not well understood. The toxic potential of inhaled particles is dependent on their size and chemical composition, and current solutions for personal exposure monitoring are expensive. This proposed effort addresses the need for a better individual exposure assessment, specifically, quantification of the health impact of ultrafine particles, and will facilitate optimal selection and implementation of air pollution control strategies.

PI_NAMEs: MAMISHEV, ALEXANDER V (contact)

PROGRAM_OFFICER_NAME: RAVICHANDRAN, LINGAMANAIDU V

PROJECT_TERMS: absorption;Address;Aerosols;Affect;Air;Air Pollution;air pollution control;Automation;Awareness;Biochemical Reaction;Carbon;Cells;Chemicals;Chemistry;Childhood;Clinical;Clinical Research;Collaborations;Collection;commercialization;Communicable Diseases;Complex;cost;Cost Analysis;cost effective;Cost Savings;COVID-19;Data;Death Rate;Deposition;design;detection platform;Development;Diesel Exhaust;Electrostatics;Elements;Environment;environmental agent;Environmental and Occupational Exposure;Environmental Pollutants;epidemiology study;Evaluation;Evidence based intervention;Exposure to;fabrication;Health;implementation facilitation;improved;In Situ;Individual;Inhalation;insight;Institutional Review Boards;instrumentation;Intervention;Laboratories;Libraries;Link;Machine Learning;machine learning algorithm;Marketing;Measurement;Medical;meter;Methods;Miniaturization;miniaturize;miniaturized sensor;Monitor;monitoring device;nanoengineering;nanomaterials;neural network;novel;Optics;Outcome;Participant;particle;particle counter;Particle Size;Particulate Matter;Performance;personal exposure monitor;Phase;pollutant;Preparation;public health research;pulmonary function;Research;Research Design;Resolution;Respiratory System;Sampling;sensor;Signal Transduction;Solid;Solubility;solvent extraction;Solvents;Source;Specificity;Spectrum Analysis;Techniques;Technology;technology platform;Testing;Time;Tissues;Tobacco smoke;tool;Ultrafine;ultrafine particle;uptake;wearable monitor;wood smoke

PROJECT_TITLE: Multispectral Sensor for Chemical Composition Analysis of Ultrafine Aerosols in Air Quality Assessment


ORG_CITY: DURHAM

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE Endometriosis is a common and devastating disease of women that causes dysmenorrhea, chronic pelvic pain, infertility, and other sequelae. The investigators in our proposed Center have helped to identify a central feature of endometriosis pathophysiology and discovered a molecular mechanism underpinning it: progesterone resistance due to SIRT1 activity. In this application, we propose to use features of progesterone resistance to develop improved diagnostic imaging techniques and deepen our pathophysiological understanding to improve approaches to therapy.

PI_NAMEs: YOUNG, STEVEN L (contact)

PROGRAM_OFFICER_NAME: TINGEN, CANDACE M

PROJECT_TERMS: Affect;Animal Model;Awareness;Bioinformatics;care providers;Cell Proliferation;Chronic;chronic pelvic pain;Clinical;Clinical Research;Collaborations;college;community setting;comparative;comparative genomics;Data;data integration;design;Detection;Development;Diagnosis;Diagnostic;Diagnostic Imaging;Disease;Dysmenorrhea;Early Diagnosis;Early treatment;Education;Education and Outreach;Endometrial;endometriosis;Energy Metabolism;Engineering;Epigenetic Process;Epithelium;Estrogen Receptors;Evaluation;Functional disorder;Future;Genomics;Goals;Growth;HDAC4 gene;Health;Health Benefit;Heart;high school;Human;human data;Image;imaging modality;Imaging Techniques;implantation;improved;In Vitro;in vitro Model;Infertility;Inflammation;Inflammation Mediators;Inflammatory;innovation;insight;Intervention;Knowledge;Lesion;lipid mediator;Macaca mulatta;Metabolic;Methods;Modeling;Molecular;Molecular Target;Monkeys;Mus;non-invasive imaging;nonhuman primate;noninvasive diagnosis;novel;Operative Surgical Procedures;overexpression;Pain;Patients;Personal Satisfaction;Play;Post-Translational Protein Processing;pre-clinical;prevent;Process;Progesterone;Progesterone Receptors;protein function;Proteins;Provider;receptor expression;Research Personnel;Resistance;Resolution;Role;Scientist;Signal Transduction;SIRT1 gene;Stigmatization;synergism;System;Testing;Testosterone;Therapeutic;therapeutic target;Tissues;tool;Uterus;western diet;Woman;women's treatment;young woman

PROJECT_TITLE: Collaborative Center to Develop Improved Diagnostic and Therapeutic Approaches to Endometriosis


PROJECT_TITLE: Center Administrative Core


NIH_SPENDING_CATS: Biomedical Imaging;Clinical Research;Contraception/Reproduction;Endometriosis;Estrogen;Infertility;Pain Research;Women's Health Research

PROJECT_TERMS: Address;Affect;aged;Anatomy;Anti-Inflammatory Agents;Arachidonic Acids;Area;Bioinformatics;cancer risk;Cell Proliferation;Chronic;chronic pain;comparative genomics;Data;Defect;Dependence;Detection;Development;Diagnosis;Diagnostic;Diagnostic Imaging;Diagnostic tests;Disease;disease diagnosis;disease model;Docosahexaenoic Acids;Dysmenorrhea;Eicosapentaenoic Acid;Endometrial;endometriosis;Endometrium;Energy Metabolism;Enzymes;Epigenetic Process;Estradiol;Estrogen Receptors;Estrogens;Etiology;eutopic endometrium;Evaluation;Exhibits;experience;Fertility;FPR2 gene;Functional disorder;Gadolinium;Goals;GPR32 gene;HDAC4 gene;Human;Image;imaging approach;improved;Individual;Infertility;Inflammation;Inflammatory;insight;Investigation;Knowledge;Laparoscopy;Lesion;lipid mediator;Location;Macaca mulatta;Magnetic Resonance Imaging;Malignant neoplasm of ovary;Mass Spectrum Analysis;Measurement;Mediator;Metabolic;Modeling;mouse model;Multimodal Imaging;Mus;new therapeutic target;nonhuman primate;novel;novel imaging technique;novel strategies;novel therapeutic intervention;Operative Surgical Procedures;overexpression;Oxidative Stress;Pain;Papio;Pathogenesis;Peritoneal;Play;Positron-Emission Tomography;Post-Translational Protein Processing;precision medicine;prevent;Process;Production;Progesterone;Progesterone Receptors;Progestins;prognostic;Proliferating;Proteins;receptor;receptor expression;Recurrence;Recurrent disease;reproductive;Research Personnel;Resistance;Resolution;response;Role;SIRT1 gene;steroid hormone;Steroid Receptors;synergism;Techniques;Therapeutic;Tissues;tool;Tracer;translational approach;treatment response;Uterine cavity;Woman;women's treatment

PROJECT_TITLE: Diagnosis and Treatment of Endometriosis: A Translational Approach


NIH_SPENDING_CATS: Clinical Research;Contraception/Reproduction;Endometriosis;Infertility;Pain Research;Women's Health Research

PI_NAMEs: JEONG, JAE-WOOK  (contact)

PROJECT_TERMS: Affect;Age;Bioinformatics;Biological Availability;Chronic;chronic pelvic pain;Complement;Development;Diagnosis;Diagnostic;Disease;Disease regression;Dose;Elements;Endometrial;endometriosis;endometriosis-related infertility;Endometrium;Engineering;Epigenetic Process;Estrogens;eutopic endometrium;Event;FDA approved;fertility preservation;Functional disorder;gene repression;Genes;Goals;Growth;HDAC4 gene;Histone Deacetylase;Human;human tissue;Huntington Disease;Impairment;improved;Incidence;Infertility;Inflammation;Inflammatory;inhibitor;innovation;Lesion;Maintenance;Mediating;Medical;Menstrual cycle;Modeling;Molecular;mouse model;Mus;Nature;non-invasive imaging;nonhuman primate;novel;novel strategies;novel therapeutic intervention;Operative Surgical Procedures;overexpression;Pelvic Pain;Pharmaceutical Preparations;Play;pre-clinical;pre-clinical assessment;Progesterone;Progestins;Recurrent disease;Reporter;reproductive;Resistance;response;Risk;Role;side effect;Signal Transduction;SIRT1 gene;Therapeutic;therapeutic target;Time;Tissues;transcriptomics;Uterus;Woman

PROJECT_TITLE: SIRT1 as a Therapeutic Target in Endometriosis


NIH_SPENDING_CATS: Biomedical Imaging;Contraception/Reproduction;Endometriosis;Estrogen;Nutrition;Pain Research;Women's Health Research

PI_NAMEs: SLAYDEN, OV D (contact)

PROJECT_TERMS: Address;aerobic glycolysis;Affect;Age;Animals;Archives;Biological Markers;Cellular Metabolic Process;Child;Chronic;Clinical;Clinical Trials;Collaborations;Consumption;contrast enhanced;contrast imaging;Deacetylase;Diagnosis;diagnosis standard;Diagnostic;diagnostic strategy;Dichloroacetate;Diet;Disease;Early Diagnosis;Emission-Computed Tomography;Endometrial;endometriosis;Endometrium;Energy Metabolism;Environment;Enzymes;Estrogen Receptors;Estrogens;Evaluation;Fatty acid glycerol esters;Fostering;Functional disorder;Future;Goals;Huntington Disease;Image;immune cell infiltrate;Impairment;improved;Infertility;Inflammation;Inflammation Mediators;Inflammatory;inflammatory marker;inhibitor;insight;Lactic acid;Laparoscopy;Lesion;longitudinal analysis;Macaca;Magnetic Resonance Imaging;Malignant Neoplasms;Measures;Mediating;Mediator;Medical;Metabolic;Metabolic Diseases;Metabolic dysfunction;Metabolic Marker;Metabolic Pathway;Metabolism;metabolomics;Methods;Mitochondria;Modeling;Molecular;Monitor;Monkeys;mouse model;nonhuman primate;novel;novel strategies;novel therapeutics;obesogenic;Organ;Ovarian;Pain;Peritoneal;Peritoneal Fluid;Polycystic Ovary Syndrome;Positron-Emission Tomography;Pre-Clinical Model;Progesterone;Progesterone Receptors;Proteins;Pyruvate;pyruvate dehydrogenase;Regulation;Reporting;reproductive;Research Personnel;Resistance;Resolution;Respiration;response;Review Literature;Role;Sampling;Schedule;sensor;Serum;Severities;side effect;Signal Transduction;Sir2-like Deacetylases;SIRT1 gene;Staging;Steroid Receptors;symptom management;systemic inflammatory response;targeted treatment;Testing;Testosterone;Therapeutic;therapeutic target;Tissues;Tracer;ultrasound;Uterus;Warburg Effect;western diet;Woman;Work;X-Ray Computed Tomography

PROJECT_TITLE: Imaging and treatment of endometriosis in nonhuman primates


NIH_SPENDING_CATS: Behavioral and Social Science;Chronic Pain;Clinical Research;Contraception/Reproduction;Endometriosis;Health Services;Pain Research;Pediatric;Prevention;Women's Health Research

PI_NAMEs: DASOUKI ABU-ALNADI, NOOR  (contact)

PROJECT_TERMS: Absenteeism;Adolescence;Adolescent;adolescent woman;Age;Area Health Education Centers;associated symptom;Awareness;barrier to care;chronic painful condition;Clinical;community engagement;Community Outreach;Detection;Diagnosis;Diagnostic;Disease;Disease Progression;Dyschezia;Dysmenorrhea;Dyspareunia;Dysuria;Early Intervention;Education;Education and Outreach;Educational Curriculum;Educational Status;endometriosis;Etiology;Event;experience;Facebook;Fostering;Goals;Grant;Health;Health education;health equality;Health Personnel;high school;High School Student;higher education;hormone therapy;Hygiene;improved;Information Dissemination;Instagram;junior high school;Knowledge;Lead;Learning;lectures;long-term sequelae;Media Campaign;Menarche;Menstruation;Menstruation Disturbances;Middle School Student;Non-Steroidal Anti-Inflammatory Agents;North Carolina;Nursing Education;outreach;Pain;Pamphlets;Parents;Pathology;Patients;Pelvic Pain;Pelvis;Persistent pain;Physicians;Policy Maker;Prevention;programs;Provider;Publishing;Reaction;Reporting;reproductive;school district;School Nursing;Schools;Series;Sexual Health;social;social media;social stigma;Specialist;Stereotyping;Students;Symptoms;teacher;Therapeutic;Time;Training;Training Programs;Twitter;Universities;Uterine hemorrhage;virtual;web site;Work;young woman

PROJECT_TITLE: Endometriosis Education Outreach


NIH_SPENDING_CATS: Biotechnology;Contraception/Reproduction;Endometriosis;Genetics;Human Genome;Women's Health Research

PI_NAMEs: COX, LAURA A (contact)

PROJECT_TERMS: Affect;Agreement;Archives;ATAC-seq;Binding;Bioinformatics;Chromatin;Cleavage Under Targets and Release Using Nuclease;comparative genomics;Data;data management;data sharing;data warehouse;Databases;Dedications;Deposition;Diagnosis;Diagnostic;Disease;Endometrial Stromal Cell;endometriosis;Endometrium;Ensure;epigenome;epigenomics;Epithelial Cells;Foundations;Functional disorder;Genes;Genetic Transcription;genetically modified cells;genome-wide;Genomics;Goals;Human;improved;Individual;Infertility;innovation;Laboratories;Lesion;Literature;Macaca mulatta;Marsupialia;metabolome;metabolomics;Methodology;Modeling;Molecular;Molecular Analysis;Monkeys;Mus;nonhuman primate;Pathway Analysis;Pathway interactions;Peritoneal Fluid;Phase;phenotypic data;Plasma;Practice Management;precision medicine;Process;public database;Publishing;Research Personnel;Rhesus;Rodent;Role;Sampling;SIRT1 gene;success;Therapeutic;Tissue Sample;Tissues;tool;transcriptome;transcriptome sequencing;transcriptomics;United States National Institutes of Health;Woman

PROJECT_TITLE: Comparative Genomics and Bioinformatics Core


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: SAN ANTONIO

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

PHR: The retina detects, computes, and transmits visual information to brain through intricate synaptic networks among five major neuronal types: photoreceptors, horizontal cells, bipolar cells, amacrine cells, and retinal ganglion cells. Amacrine cell is the most diverse but least understood retinal neuron. This study will use a multidisciplinary approach to investigate the role of a wide-field amacrine cells called TH2-AC in contrast and motion detection during daytime. Success of the study will bring better understanding on information processing in retina and will benefit current and future therapeutic attempts in treating human blinding diseases.

PI_NAMEs: CHEN, CHING-KANG JASON (contact)

PROGRAM_OFFICER_NAME: WRIGHT, CHARLES BAKER

PROJECT_TITLE: The function of wide-field amacrine cells in mammalian retina

STUDY_SECTION: BDE

STUDY_SECTION_NAME: Biology and Development of the Eye Study Section[BDE]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Stroke;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

PHR: PROJECT NARRATIVE Diseases of the small vessels of the brain contribute to the development of vascular cognitive impairment and dementia (VCID). Because vascular diseases can be prevented and treated, there is an incredible potential for the development of interventions to stop or treat the disease; however, more research is needed to develop robust biomarkers that can be used in clinical trials of VCID. This study seeks to perform a comprehensive longitudinal validation of candidate biomarkers for diseases of the small vessels of the brain in a diverse sample of South Texas, particularly in Hispanic and African Americans as they face an increased risk of VCID.

PI_NAMEs: FORNAGE, MYRIAM ;SATIZABAL, CLAUDIA L (contact);SAVITZ, SEAN I;SESHADRI, SUDHA

PROGRAM_OFFICER_NAME: MCGAVERN, LINDA

PROJECT_TERMS: African American;African American population;Age;Aging;American;Angiography;Autopsy;biobank;Biological Markers;biomarker validation;Blood;Blood Platelets;Blood specimen;Blood Vessels;Brain;brain magnetic resonance imaging;brain tissue;candidate marker;candidate validation;Categories;Cerebral small vessel disease;Cerebrospinal Fluid;cerebrovascular reactivity;Cerebrum;Clinic;Clinical;Clinical Trials;Cognition;Cognitive;cohort;Collaborations;Consensus;Consent;Data;Data Set;Dementia;dementia burden;design;Development;Diagnosis;digital pathology;Dimensions;Disease;Enrollment;Epidemiology;Ethnic Origin;Ethnic Population;Etiology;European;Face;follow-up;Fostering;Framingham Heart Study;Genetic;genomic epidemiology;Goals;Heart;Hispanic;Hispanic Americans;Image;imaging biomarker;Impaired cognition;Intervention;Leadership;Liquid substance;Magnetic Resonance Imaging;Measures;Medical History;Mexican Americans;Microvascular Dysfunction;mild cognitive impairment;Modification;Monitor;multi-ethnic;multidisciplinary;National Institute of Neurological Disorders and Stroke;neuropathology;Neuropsychology;Not Hispanic or Latino;Optical Coherence Tomography;Outcome;Participant;Persons;Pharmacodynamics;Phase;Phenotype;Plasma;population based;Population Heterogeneity;Population Study;prevent;Primary Care;prognostication;programs;Protocols documentation;Qualifying;Race;racial population;Recommendation;recruit;Renal function;Research;research clinical testing;Research Personnel;Risk;Sampling;screening;Serum;Shapes;Site;South Texas;Specific qualifier value;Stroke;stroke trials;Subgroup;symposium;Telephone;therapy development;Validation;vascular cognitive impairment and dementia;vascular contributions;Vascular Diseases;vascular risk factor

PROJECT_TITLE: Multiethnic Validation of VCID biomarkers in South Texas


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: Newark

ORG_DEPT: NEUROLOGY

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: Project Narrative The number of people in the world suffering from neurological disorders is increasing rapidly, and many of these diseases have no good treatments much less cures. To address this unmet need to find better treatments for these disorders, this program aims to train laboratory-based scientists working on disease relevant projects to advance their discoveries to clinical trials and eventually as treatments for these patients. The comprehensive program combines traditional and experiential learning opportunities.

PI_NAMEs: MOURADIAN, M. MARAL  (contact)

PROGRAM_OFFICER_NAME: WEIGAND, LETITIA ALEXIS

PROJECT_TERMS: Neurosciences;Training;Translating

PROJECT_TITLE: Training in Translating Neuroscience to Therapies


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Gene Therapy;Genetics;Neurodegenerative;Neurosciences;Orphan Drug;Pediatric;Rare Diseases

ORG_CITY: GAINESVILLE

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: Project Narrative The overall goal of this proposal is to identify an immune modulation strategy to increase safety and efficacy of an adeno-associated virus (AAV)-mediated gene therapy approach for the treatment of Friedreich’s ataxia, a devastating genetic disorder affecting the heart and the nervous system in children and young adults. First, we will develop and optimize a safe and effective immune modulation approach to prevent immune responses to the viral capsid and to allow for safe and effective repeated administration of AAV. Second, we will identify a strategy to reduce anti-AAV antibody titer in animals with pre-existing immunity to AAV and allow for safe and effective therapeutic AAV dosing in pre-exposed animals. Since experiments will focus on safety and levels of transgene expression, we will use wild type mice and non-human primates (NHPs). The successful completion of this proposal will lead to important breakthroughs for Friedreich’s ataxia as well as for the application of gene therapy in many other inherited neuromuscular diseases.

PI_NAMEs: CORTI, MANUELA  (contact)

PROGRAM_OFFICER_NAME: BOSHOFF, CHRIS

PROJECT_TERMS: Acceleration;adaptive immune response;Address;adeno-associated viral vector;adenovirus mediated delivery;Adverse event;Affect;Age;Animals;Antibodies;Antibody Formation;Antibody titer measurement;autosome;B-Cell Activation;B-Lymphocytes;belimumab;Biodistribution;blood-brain barrier crossing;Bortezomib;Capsid;Capsid Proteins;Cardiac;Cessation of life;Child;Clinical;Clinical Data;Clinical Research;Data;Dependovirus;Disease;Dose;effective therapy;Enrollment;Environmental Exposure;Excision;Exclusion;experimental study;Exposure to;Face;first-in-human;frataxin;Friedreich Ataxia;Gene Expression;gene replacement;gene replacement therapy;gene therapy;Gene therapy trial;Genes;Genetic;Genetic Diseases;Goals;Heart;Hematology;Histopathology;Human;Immune response;Immunity;immunogenicity;Immunoglobulin-Secreting Cells;immunomodulatory strategy;immunoregulation;improved;Individual;Infusion procedures;Inherited;Inherited Spinocerebellar Degenerations;Intravenous Immunoglobulins;life span;Longevity;Mediating;Mitochondria;Monoclonal Antibodies;mTOR Inhibitor;Mus;Nervous System;Nervous System Disorder;neuromuscular;Neuromuscular Diseases;nonhuman primate;participant enrollment;Patients;Persons;Plasma Cells;pre-clinical;preclinical study;premature;prevent;Product Approvals;programs;Progressive Multifocal Leukoencephalopathy;Proteasome Inhibitor;Published Comment;Quality of life;Reaction;Recombinants;Regimen;response;rituximab;Route;Safety;Sirolimus;success;System;T-Cell Activation;T-Lymphocyte;Testing;Therapeutic;Therapeutic Effect;therapeutically effective;Time;Toxic effect;Toxicology;transgene expression;Transgenes;Treatment Efficacy;Trinucleotide Repeat Expansion;vector;Ventricular Arrhythmia;Viral;Wild Type Mouse;Work;young adult

PROJECT_TITLE: Immunomodulation Approaches to Improve Safety And Efficacy of Gene Therapy Treatment in Friedreich’s Ataxia

STUDY_SECTION: NSD

STUDY_SECTION_NAME: Neurological Sciences and Disorders B Study Section[NSD-B]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Depression;Genetics;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Serious Mental Illness

ORG_CITY: ALBUQUERQUE

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR

ORG_STATE: NM

PHR: Project Narrative Major depressive disorder (MDD) is a leading cause of disability and lost productivity. I have found that both the number and the activity of newborn neurons in an area of the brain called the hippocampus are necessary for the effects of antidepressants. The goal of these studies is to understand the role of these newborn neurons in MDD to enable the development of new and more effective antidepressants.

PI_NAMEs: TUNC-OZCAN, ELIF  (contact)

PROGRAM_OFFICER_NAME: HUPALO, SOFIYA

PROJECT_TERMS: Acute;Address;Anatomy;Animal Model;anti-depressive agents;antidepressant effect;Anxiety;Area;Behavior;Behavioral;behavioral phenotyping;biological adaptation to stress;Brain;cell type;Cells;Chronic;Chronic stress;Clinical;Cognition;Complex;Data;dentate gyrus;depressed patient;depression model;depressive symptoms;Development;disability;Disease;Dorsal;effective therapy;excitatory neuron;experience;Faculty;Functional disorder;Gene Combinations;Gene Expression;Genes;Genetic;genetic manipulation;Genetic Transcription;Goals;Grant;granule cell;Hippocampus;Impairment;improved;Knowledge;Life;Link;Major Depressive Disorder;Maps;Mediating;Memory;Mentors;Molecular;molecular phenotype;network models;neural;Neurobiology;neurogenesis;Neurons;New Mexico;new therapeutic target;Newborn Infant;newborn neuron;Patients;Pattern;Persons;Pharmaceutical Preparations;Phase;Phenotype;Positioning Attribute;Pre-Clinical Model;presynaptic;prevent;Production;Productivity;promote resilience;Property;Publications;rabies viral tracing;receptor;response;Role;Secure;side effect;Signal Pathway;social;Source;Stream;Stress;Synapses;Synaptic plasticity;Technology;Testing;Therapeutic;therapeutic target;transcriptomics;Transgenic Mice;Universities;Work

PROJECT_TITLE: Neural activity and circuitry-mediated hippocampal stress responses


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Brain Disorders;Cardiovascular;Drug Abuse (NIDA only);Neurosciences;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: LA JOLLA

ORG_NAME: SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

PHR: PROJECT NARRATIVE Opioid use disorder (OUD) is a major public health crisis in the United States, with >50,000 overdose deaths in 2017 alone. The candidate lead compound of this drug development application is based on the neurotensin system, which represents a promising target for the treatment of addiction; however, its therapeutic utility has not been fully realized due to the lack of brain-penetrant, systemically available compounds with non-limiting side effects. The research purposed here will further develop a potential, brain-penetrant treatment for OUD through to testing the drug in healthy volunteers, with the ultimate goal of testing the drug’s efficacy in phase 2 studies.

PI_NAMEs: BARAK, LAWRENCE S.;JACKSON, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: WHITE, DAVID A

PROJECT_TERMS: addiction;Address;Amphetamines;analog;Arrestins;beta-arrestin;Binding;Biochemical;Biological Assay;Brain;Canis familiaris;Cardiovascular system;Cells;Central Nervous System;Clinical;clinical candidate;clinical development;Cocaine;Cyclic GMP;Development;Disease;Dopamine;Dose;drug development;drug efficacy;Drug Kinetics;drug testing;effective therapy;efficacy study;Ensure;Evaluation;Formulation;G-Protein-Coupled Receptors;Goals;healthy volunteer;high risk;human induced pluripotent stem cells;Hypotension;improved;In Vitro;in vivo;in vivo Model;Individual;Lead;lead candidate;Ligands;Literature;manufacture;Medical;Miniature Swine;Modeling;Molecular Target;Monitor;Monkeys;mouse model;natural hypothermia;Neurotensin;novel;Opioid;opioid use disorder;Oral;overdose death;Pharmacodynamics;Pharmacology;Pharmacology Study;Phase;phase 1 study;phase 2 study;Phosphorylation;Physiological;Physiology;Plethysmography;Positioning Attribute;postsynaptic neurons;preclinical safety;presynaptic;Public Health;receptor;receptor binding;remifentanil;Report (document);Research;Rewards;Rodent;Safety;scale up;Self Administration;Series;side effect;Signal Transduction;stability testing;substance abuse treatment;Substance Use Disorder;substance use treatment;System;Therapeutic;Toxicology;United States;Ventilatory Depression

PROJECT_TITLE: Development of SBI-553, an allosteric modulator of NTR1, for the treatment of substance use disorders


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Rural Health;Social Determinants of Health

ORG_CITY: HERSHEY

ORG_NAME: PENNSYLVANIA STATE UNIV HERSHEY MED CTR

PHR: PROJECT NARRATIVE - OVERALL The Penn State Clinical and Translational Science Institute advances clinical and translational science to improve health and combat disease. It does this through collaboration and team science across scientific fields, an infrastructure of research excellence and data-driven decision-making, strong partnerships, and educational opportunities for a diverse and expanding clinical and translational science workforce. This project builds on the lnstitute's cross-university foundation and generates innovation, enables efficient research, educates the existing and next generation of scientists, and focuses on the health needs of rural communities.

PI_NAMEs: KRASCHNEWSKI, JENNIFER L. (contact)

PROGRAM_OFFICER_NAME: LEYVA, FRANCISCO

PROJECT_TERMS: Acceleration;Address;Area;Biomedical Research;Cities;Clinic;Clinical and Translational Science Awards;Clinical Informatics;Clinical Sciences;Clinical Trials;Collaborations;college;combat;Communities;community collaboration;community engagement;community partners;Complex;Conduct Clinical Trials;Consultations;Data;Decision Making;Development;Disease;economic disparity;Education;Elderly;empowerment;Ensure;Evaluation;Evidence based practice;Evolution;Expenditure;Foundations;Funding;Generations;Goals;Grant;Health;health care availability;health care service organization;Health Personnel;Health Professional;Health Promotion;Health system;Healthcare;Hospitals;improved;Informatics;innovation;Institution;Insurance Carriers;Interdisciplinary Study;Knowledge;Learning;life span;Medical center;medical schools;Medicine;member;Mission;next generation;novel strategies;outreach;Patients;Persons;Pilot Projects;Population;prevent;Prevention;Process;programs;protocol development;Provider;Reproducibility;Research;Research Infrastructure;Research Personnel;Research Support;Resource Sharing;Rural;rural area;Rural Community;Rural Population;Science;Scientist;Services;social;Source;success;Testing;Training;training project;translational pipeline;Translational Research;United States National Institutes of Health;Universities;Vision;Work


NIH_SPENDING_CATS: Biotechnology;Chronic Pain;Gene Therapy;Genetics;Neurosciences;Opioids;Pain Research

ORG_CITY: SAN DIEGO

ORG_NAME: NAVEGA THERAPEUTICS, INC.

PHR: PROJECT NARRATIVE Due to the lack of efficacious alternative treatment options, chronic pain is often treated with opioids despite the risk of addiction and side effects. With the advent of gene therapy, it is now possible to specifically target pain pathways at the molecular level. The goal of this study is to further develop and evaluate the efficacy and safety of a non-addictive, alternative analgesic that can epigenetically repress expression of NaV1.7, a sodium channel that is important for sensing pain.

PI_NAMEs: ALEMAN GUILLEN, FERNANDO  (contact);MORENO, ANA MARIA

PROJECT_TERMS: addiction;Affect;alternative treatment;Analgesics;animal efficacy;Animal Model;animal safety;Antibodies;Binding;Biological Assay;Burning Pain;cancer survival;Cell Line;Cells;cellular transduction;Chromatography;chronic pain;chronic pain management;clinical development;Clinical Trials;Congenital Pain Insensitivity;CRISPR-mediated transcriptional activation;CRISPR/Cas technology;density;Dependovirus;design;Development;Diabetes Mellitus;Disease;DNA;dosage;Dose;drug development;Drug Kinetics;Economic Burden;efficacious treatment;efficacy evaluation;Elderly;Engineering;Epigenetic Process;epigenome;Erythromelalgia;Evaluation;Failure;Feasibility Studies;gain of function mutation;gene therapy;Genome;Goals;Guide RNA;Harvest;healing;Human;Human Cell Line;improved;In Vitro;induced pluripotent stem cell;innovation;interest;lead candidate;lead optimization;Libraries;Limb structure;loss of function;manufacture;Methods;Molecular;Molecular Conformation;Mus;Mutation;Neurons;nonhuman primate;novel;novel therapeutics;Opioid;opioid epidemic;Organ;Pain;Pain management;pain reduction;pain relief;Pathway interactions;Patients;Peptides;Persistent pain;Persons;Pharmaceutical Preparations;Phase;Plasmids;Population;pre-clinical;prescription opioid;Prevalence;promoter;Proteins;Quality of life;rational design;Reagent;Repression;response;restraint;Risk;RNA;Safety;safety study;screening;side effect;small molecule inhibitor;Societies;socioeconomics;Sodium Channel;Specificity;Spinal Ganglia;Survival Rate;System;Testing;Therapeutic;Time;Toxic effect;Toxicology;Transcription Repressor;Transfection;transgene expression;Transgenes;Translating;Tropism;Variant;Zinc Fingers

PROJECT_TITLE: Preclinical optimization of a gene therapy for erythromelalgia and chronic pain

STUDY_SECTION_NAME: Neurological Sciences and Disorders A Study Section[NSD-A]


NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Immunotherapy;Lung;Lung Cancer;Patient Safety;Radiation Oncology

ORG_CITY: PHILADELPHIA

ORG_NAME: THOMAS JEFFERSON UNIVERSITY

PHR: Lung cancer patients that get treated with radiotherapy and immunotherapy are at a risk of developing pulmonary side-effects from treatment. Our project proposes to use quantitative imaging to reduce toxicity for patients treated with aggressive radiotherapy and immunotherapy regimens in clinical trials. The developed novel imaging modality can improve quality of life for lung cancer patients and enable investigation of more- aggressive treatment approaches.

PI_NAMEs: CASTILLO, EDWARD ;CASTILLO, RICHARD ;VINOGRADSKIY, YEVGENIY  (contact)

PROGRAM_OFFICER_NAME: TATA, DARAYASH B

PROJECT_TERMS: Address;aggressive therapy;Cancer Patient;Chest;Clinical;clinical care;Clinical Trials;clinically relevant;clinically significant;Combined Modality Therapy;Computer software;Coughing;Data;Data Set;design;Development;Dose;four-dimensional computed tomography;Generations;Human;Image;Image Analysis;imaging modality;Immunotherapy;immunotherapy clinical trials;improved;improved outcome;innovation;Intervention;Investigation;Lung;lung basal segment;Malignant neoplasm of lung;Maps;Methods;novel;participant enrollment;patient response;Patients;perfusion imaging;Probability;prospective;pulmonary function;Pulmonary Inflammation;Quality of life;quantitative imaging;Radiation;radiation effect;Radiation Pneumonitis;Radiation therapy;Regimen;Reproducibility;response;Risk;Shortness of Breath;side effect;standard of care;success;Techniques;Therapeutic;Therapy Clinical Trials;Thoracic Oncology;Toxic effect;treatment planning;Treatment Side Effects;Validation;ventilation

PROJECT_TITLE: Quantitative Lung Function Imaging to Reduce Toxicity for patients treated with Radiation and Immunotherapy


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Emergency Care;Hematology;Physical Injury - Accidents and Adverse Effects

ORG_CITY: BIRMINGHAM

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE This application is for the “Trauma Resuscitation with Group O Whole Blood Or Products” (TROOP) trial, an 1,100-patient, 12-center, pragmatic, multicenter, phase III randomized clinical trial to evaluate the clinical effectiveness and cost-effectiveness of whole blood, compared with component blood therapy, in trauma patients predicted to require large volume blood transfusions. Hemorrhage remains the most common cause of preventable death after injury, and whole blood has several potential advantages over component therapy (the current standard of care). The TROOP trial is exceedingly well positioned to improve mortality from trauma, and reduce the number of preventable deaths resulting from hemorrhagic shock.

PI_NAMEs: HOLCOMB, JOHN B;JANSEN, JAN O (contact);WANG, HENRY E.

PROGRAM_OFFICER_NAME: KINDZELSKI, ANDREI L

PROJECT_TERMS: Accounting;Adult;Affect;Age;age group;Alabama;Anticoagulants;Benefits and Risks;Blood;Blood Banks;Blood Coagulation Disorders;Blood Donations;Blood Platelets;blood product;Blood Transfusion;Blood Volume;Cardiac;Cause of Death;Cessation of life;Child;Clinical;Clinical effectiveness;clinical practice;Clinical Trials;Collaborations;compare effectiveness;cost;cost effectiveness;Critical Care;Critical Illness;Data;Data Coordinating Center;design;Early treatment;Effectiveness;Eligibility Determination;Emergency Care;Enrollment;Erythrocytes;experience;feasibility trial;Funding;Grant;Health Sciences;Heart Diseases;Hemorrhage;Hemorrhagic Shock;Hospitals;Hour;improved;Incidence;Injury;innovation;Knowledge;Leadership;Life;Lung;Malignant Neoplasms;Military Personnel;Modernization;mortality;Multicenter Trials;multidisciplinary;National Heart, Lung, and Blood Institute;novel;Outcome;Patients;Phase;Plasma;platelet function;Population;Positioning Attribute;practice setting;preventable death;primary outcome;Productivity;Public Health Schools;Randomized;randomized, clinical trials;Recommendation;reconstitution;Research;Research Personnel;Resources;Resuscitation;Retrospective Studies;Safety;Sample Size;Science;severe injury;Shock;standard of care;Testing;Texas;Transfusion;Trauma;trauma care;trauma centers;Trauma patient;Traumatic Hemorrhage;Traumatic injury;United States;Universities;Whole Blood

PROJECT_TITLE: 1/2 Trauma Resuscitation with Group O Whole Blood Or Products (TROOP) Trial

STUDY_SECTION: CLTR

STUDY_SECTION_NAME: Clinical Trials Review Study Section[CLTR(JA)]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_CITY: NASHVILLE

ORG_NAME: VIRTUOSO SURGICAL, INC.

PHR: Narrative: Public Health Relevance More than 80,000 patients are diagnosed with bladder cancer each year in the USA alone, and 78% of them face recurrence, which is believed to be because surgical instrumentation limitations currently require tumors to be removed piecemeal. We propose a new endoscopic robotic system that will give surgeons two tiny, dexterous surgical instruments in the bladder, enabling removal of the whole tumor, in one piece. Accomplishing this will enable surgeons to immediately initiate aggressive chemotherapy and/or bladder removal for patients whose disease has progressed into the muscle, while sparing patients with localized disease from the morbidity of aggressive treatments.

PI_NAMEs: HENDRICK, RICHARD JOSEPH (contact)

PROGRAM_OFFICER_NAME: ASHMONT, KARI RICH

PROJECT_TERMS: aggressive therapy;Animals;arm;biomaterial compatibility;Bladder;Bladder Neoplasm;Cadaver;cancer cell;Cauterize;chemotherapy;Clinical;clinically significant;commercialization;Compensation;Curved Tube;Cystectomy;design;dexterity;Diagnosis;Diameter;Disease;Dissection;Elasticity;Electromagnetics;Electronics;Electrosurgery;Endoscopes;Endoscopic Surgical Procedures;Ensure;Evaluation;Excision;experience;experimental study;Face;Force of Gravity;Goals;Hand;Hemorrhage;Human;improved;innovation;instrument;instrumentation;Invaded;Life;Localized Disease;Malignant neoplasm of urinary bladder;Mechanics;Morbidity - disease rate;mortality;Motion;Motor;Movement;Mucous Membrane;Muscle;Needles;Newly Diagnosed;nitinol;Operative Surgical Procedures;Pathologic;Patients;Performance;Persons;Phase;Preparation;Primary Neoplasm;Process;public health relevance;Recurrence;Recurrent tumor;Resected;Robot;robot control;robotic system;Robotics;Rotation;Safety;Salvelinus;Sampling;Specimen;Staging;State of Zero Gravity;Sterility;Stream;Support System;Surgeon;Surgical Instruments;System;Testing;Time;Tissues;tool;Tube;tumor;Urethra;usability;Validation;Visualization

PROJECT_TITLE: A Robotic System to Remove Bladder Tumors Intact: The Key to Making Lifesaving Treatment Decisions

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ISB-W(12)B]


NIH_SPENDING_CATS: Brain Disorders;Cerebrovascular;Clinical Research;Neurosciences;Physical Injury - Accidents and Adverse Effects;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE Traumatic brain injury (TBI) is one of the leading causes of death and disability worldwide because the disease is highly heterogeneous with complex mechanisms of pathogenesis and the role of the peripheral immune response on the brain remains unexplored. This project will establish an innovative perfused blood / blood-brain barrier three dimensional interface model that will allow us to examine the relationship between blood components (plasma, immune cells) and the blood-brain barrier in healthy conditions and following TBI. This model may facilitate discovery or analysis of potential biomarkers for TBI and evaluate the efficacy of potential therapeutics that target the systemic inflammatory-driven brain pathophysiology in this disease.

PI_NAMEs: AGALLIU, DRITAN  (contact);LIS, RAPHAEL ;PEDERSEN, IRENE MUNK

PROGRAM_OFFICER_NAME: CHARETTE, MARC F

PROJECT_TERMS: 3-Dimensional;Astrocytes;Biological;Biological Process;Blood;Blood - brain barrier anatomy;Blood brain barrier dysfunction;blood perfusion;Blood Vessels;blood-brain barrier function;blood-brain barrier permeabilization;Brain;brain endothelial cell;Brain Injuries;Cause of Death;Cell Line;Cell Physiology;Cells;Cellular biology;Chemicals;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;cytokine;Diffusion;disability;Disease;efficacy evaluation;Extravasation;Foundations;Functional disorder;Heterogeneity;Human;human induced pluripotent stem cells;Image;Immune;immune activation;Immune response;Immune system;Impairment;Incidence;induced pluripotent stem cell;Inflammatory;Injury;innovation;interdisciplinary approach;Label;Macrophage;Maintenance;Mediating;Methods;Military Personnel;Modeling;Molecular;Nature;Nervous System Disorder;Neuroprotective Agents;neurovascular unit;novel;Nutrient;Organoids;Outcome;Pathogenesis;Patients;Perfusion;Pericytes;Peripheral;Pharmaceutical Preparations;Phase;Physiological;Plasma;Plasma Proteins;pluripotent stem cell differentiation;Population;potential biomarker;programs;Property;Proteins;Protocols documentation;Publications;Publishing;RNA;Role;seal;Severities;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Somatic Cell;Source;Structure;System;T-Lymphocyte;TBI Patients;Testing;therapeutic target;three-dimensional modeling;Tight Junctions;tool;trafficking;transcription factor;transcriptome sequencing;transcriptomics;transcytosis;Traumatic Brain Injury;Treatment Efficacy;Vascularization;Viral

PROJECT_TITLE: Assessing the effects of peripheral immune activation on the NVU following TBI using a vascularized and perfused human blood/BBB model


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Dental, Oral, and Craniofacial Disease;Eye Disease and Disorders of Vision;Genetics;Pediatric;Precision Medicine;Women's Health Research

ORG_DEPT: DENTISTRY

PHR: PROJECT NARRATIVE This project is to determine molecular mechanisms of cytoplasmic mitochondrial double-stranded RNA (dsRNA) sensing by PKR in children with autoimmune Sjӧgren’s disease. The investigation of immune cell gene signatures and target tissue inflammation affected by dsRNA will potentially offer diagnostic and therapeutic targets in this rare cohort.

PI_NAMEs: CHA, SEUNGHEE  (contact);KIM, YOOSIK

PROGRAM_OFFICER_NAME: CHANDER, PREETHI

PROJECT_TERMS: Address;Adhesions;Adolescent;Adult;Affect;Anti-Inflammatory Agents;Area;Autoimmune;Autoimmune Diseases;Autologous;Award;B-Cell NonHodgkins Lymphoma;Bar Codes;Binding Proteins;Biological;Biological Response Modifiers;biomarker discovery;Biopsy;CD14 gene;CDW52 gene;Cell Line;Cells;Child;Childhood;Clinical;Co-Immunoprecipitations;cohort;Collaborations;Cytoplasm;Data;Data Set;Deposition;Development;Diagnostic;diagnostic biomarker;diagnostic criteria;Disease;disease diagnostic;Double-Stranded RNA;Down-Regulation;Early Intervention;Elderly;Endothelial Cells;Enrollment;Exocrine Glands;Exploratory/Developmental Grant for Diagnostic Cancer Imaging;Extravasation;eye dryness;Female;Foundations;Funding;Gene Amplification;Gene Expression;Gene Targeting;Genes;Genetic;genetic signature;Goals;Health;helicase;Heterogeneity;Homing;Hospitals;Immune;immune activation;Immunologics;Impairment;Incidence;Inflammation;Inflammatory;innate immune mechanisms;Interferons;Investigation;Knowledge;Laboratories;Lip structure;Mediating;Medical;Methylation;Mitochondria;Mitochondrial Proteins;Mitochondrial RNA;Molecular;Molecular Analysis;Molecular Disease;monocyte;monomer;multidisciplinary;multiple omics;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;Natural History;novel;Nucleic Acids;Organ;Outcome;overexpression;Particulate;Pathogenesis;Pathway interactions;Patients;Peripheral Blood Mononuclear Cell;personalized medicine;Polyribonucleotide Nucleotidyltransferase;precision medicine;Prevalence;prevent;Prognostic Marker;protein kinase R;Rare Diseases;Research;RNA;RNA Binding;RNA Degradation;RNA Helicase;RNA-Binding Proteins;sensor;simulation;single-cell RNA sequencing;Sjogren's Syndrome;Stains;STAT1 gene;Stratification;Testing;therapeutic RNA;therapeutic target;Tissues;Transcript;transcriptome sequencing;transcriptomics;United States National Institutes of Health;Up-Regulation;Validation;Xerostomia

PROJECT_TITLE: PKR sensing of mitochondrial dsRNA in childhood Sjogrens disease

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Cancer;Kidney Disease;Nanotechnology;Orphan Drug;Rare Diseases

ORG_CITY: PLANO

ORG_NAME: CLEARNANO, INC.

PHR: Narrative  Partial nephrectomy is becoming an increasingly important treatment for kidney cancer because more than 60% of kidney cancer cases are diagnosed in early, localized stages; however, accurate visualization of renal tumor and its boundary remains a long-standing technique challenge and there is a strong unmet for fluorescent imaging agents that can enhance precision of partial nephrectomy. The goal of ClearNano Inc. is to commercialize a safe, renal-tubule-secretable, tumor targeting NIR fluorescent agent, named “ClearICG” for intraoperative, hyper-fluorescence imaging of kidney cancer. The success will significantly improve oncological and renal functional outcomes while overall medical expense is significantly reduced (~20%).

PI_NAMEs: YU, MENGXIAO  (contact)

PROGRAM_OFFICER_NAME: ZHAO, MING

PROJECT_TERMS: ABCB1 gene;acute toxicity;Advanced Development;Area Under Curve;Artificial nanoparticles;Biodistribution;biomaterial compatibility;Blood;Blood Circulation;cancer cell;cancer surgery;Cancerous;Canis familiaris;Cardiovascular system;Cells;Chronic Kidney Failure;Clear Cell;Clear cell renal cell carcinoma;Clinic;Clinical;clinical translation;Clinical Trials;clinically relevant;commercialization;contrast imaging;cyanine dye;design;Diagnosis;Dose;Drug Kinetics;Enzymes;Evaluation;Event;Excision;Fluorescence;fluorescence imaging;fluorescence-guided surgery;Fluorescent Dyes;fluorophore;functional outcomes;Goals;good laboratory practice;Half-Life;Human;Image;image guided;imaging agent;imaging system;improved;In Vitro;in vivo;Indocyanine Green;Injections;innovation;intravenous injection;Investigational Drugs;Kidney;Kidney Failure;kidney imaging;Kidney Neoplasms;Life;Ligands;manufacture;manufacturing cost;Marketing;Mediating;Medical Care Costs;Molecular Weight;mouse model;Names;nanomedicine;nanoparticle;nanosized;Nanotechnology;Nature;Near-infrared optical imaging;Nephrectomy;Normal Cell;Oncology;overexpression;Papillary;patient derived xenograft model;Patient imaging;Patients;Peptides;Pharmaceutical Preparations;Pharmacology and Toxicology;Phase;Polyethylene Glycols;Postoperative Period;preservation;Production;quality assurance;Quality of life;Reaction;receptor;receptor expression;Recurrence;Regulatory Pathway;Renal Carcinoma;Renal function;Renal tubule structure;Risk;ROC Curve;Small Business Innovation Research Grant;Sprague-Dawley Rats;Subgroup;success;Surgeon;Surgical margins;Techniques;Testing;Tissues;Toxicology;Translating;Tubular formation;tumor;Visualization

PROJECT_TITLE: Advancing Fluorescence Imaging-guided Partial Nephrectomy with ClearICG

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-R(10)B]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Networking and Information Technology R&D (NITRD)

ORG_CITY: NEW HAVEN

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative Cell to cell variability in signaling networks is universal and its functional importance is now recognized across a range of different biological contexts. Therefore, predictive modeling of population variability will be of a broader interest to the cell and molecular biology community. In this proposal, we will develop a novel mechanistic and predictive computational tool to model population variability and use it to study two centrally important mammalian signaling pathways; mitogen activated protein kinase (MAPK) pathway and the mechanotransduction pathway.

PI_NAMEs: DIXIT, PURUSHOTTAM  (contact)

PROGRAM_OFFICER_NAME: NGUYEN, HAN

PROJECT_TERMS: Architecture;Area;Biochemical Process;Biological;Biology;cell behavior;Cells;Cellular biology;Collaborations;Communities;Complex;computerized tools;Computing Methodologies;Data;Development;Entropy;Family;Goals;interest;Laboratories;large scale data;mechanotransduction;Metabolism;microbiome;Mitogen-Activated Protein Kinases;Modeling;Molecular Biology;network models;neural network;novel;Outcome;Pathway interactions;Population;predictive modeling;programs;Research;Signal Pathway;Signal Transduction;Statistical Methods;Techniques;Work

PROJECT_TITLE: MANET: Maximum Entropy Neural Networks for Mechanistic Modeling of Single Cell Behavior

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-R(55)R]


NIH_SPENDING_CATS: Adolescent Sexual Activity;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Mental Health;Pediatric;Pediatric - AIDS;Prevention;Social Determinants of Health

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: Project Narrative Nigeria has the 4th highest global burden of HIV and an uncontrolled epidemic. Youth aged 15-24 have high rates of HIV incidence, while retention in care and viral suppression are both poor. The HIV epidemic in Nigeria's youth is highest in men who have sex with men (MSM) and transgender women (TW). Effective, scalable, youth-specific interventions with enhanced prevention, improved case-finding, and increased ART access and adherence support for youth living with HIV, including YMSM and YTW are critical to turn around lagging indicators across the HIV prevention and care continuum. However, to-date, no interventions have shown efficacy or undergone rigorous effectiveness and implementation research in Nigeria's complex sociocultural milieu.

PI_NAMEs: GAROFALO, ROBERT  (contact)

PROGRAM_OFFICER_NAME: RUSSO, DENISE

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Adherence;Administrator;adolescent HIV prevention;Adoption;aged;Agreement;AIDS prevention;antiretroviral therapy;care systems;Caring;case finding;Child Development;Clinic;Clinical Research;Collaborations;Complex;Continuity of Patient Care;Data;design;Development;Economics;Effectiveness;effectiveness outcome;effectiveness research;effectiveness testing;effectiveness/implementation study;effectiveness/implementation trial;Epidemic;evidence base;Exploration, Preparation, Implementation, and Sustainment;Funding;Goals;Government;Health;HIV;HIV Seronegativity;HIV Seropositivity;HIV Seroprevalence;HIV-1;Human Development;Human immunodeficiency virus test;Hybrids;implementation evaluation;implementation intervention;implementation outcomes;implementation research;implementation science;implementation strategy;improved;improved outcome;Incidence;individualized medicine;Infection;innovation;Intervention;men who have sex with men;mHealth;motivational enhancement therapy;Newly Diagnosed;Nigeria;Nigerian;outcome disparities;Participant;peer;performance site;Phase;Pilot Projects;Population;pre-exposure prophylaxis;Preparation;Prevention;primary outcome;Public Health;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Research;response;Risk;same-sex marriage;Sampling;secondary outcome;Services;social culture;social stigma;standard of care;Structure;success;Testing;transgender women;uptake;Vertebral column;Viral;Viral Load result;young men who have sex with men;Youth

PROJECT_TITLE: Intensive Combination Approach to Rollback the HIV Epidemic in Nigerian Youth (iCARE) Plus Effectiveness / Implementation Hybrid Study