NIH_SPENDING_CATS: Bioengineering;Cancer

ORG_CITY: STANFORD

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: STANFORD UNIVERSITY

PHR: NARRATIVE The Gordon Research Conference (GRC) on Signaling by Adhesion Receptors is a biennial meeting of the top investigators in the fields of cellular adhesion and signal transduction. The meeting will emphasize the structure-function relationships that underlie embryonic development, tissue homeostasis, and cancer progression. Importantly, a seminar preceding the conference and organized by and for early career scientists will promote scientific exchange and career development for researchers in the field of cellular adhesion biology.

PI_NAMEs: DUNN, ALEXANDER R (contact)

PROGRAM_OFFICER_NAME: GEORGE, CHRISTINA DAWN

PROJECT_TERMS: Academia;Acceleration;adhesion receptor;Adhesions;Area;base;Biochemical;bioimaging;Biological;Biology;Biomedical Engineering;Biophysics;Cancer Biology;cancer diagnosis;cancer therapy;career;career development;Career Mobility;Cell Adhesion;Cell-Cell Adhesion;Cell-Matrix Junction;Clinical;clinical application;Collaborations;collaborative environment;Communities;Complex;cost;Development;Developmental Biology;Discipline;Disease;Elements;Embryonic Development;Engineering;Environment;Feedback;Fees;Fostering;Funding;Future;Gender;Goals;Government;graduate student;Growth Factor;Growth Factor Receptors;Health;Homeostasis;Imaging Device;Industry;International;Knowledge;Location;Malignant Neoplasms;Mechanics;meetings;Mentors;Mentorship;New Hampshire;novel;Oral;Participant;Pathogenesis;Pathologic;peer;physiologic model;Physiological;Play;Policies;Postdoctoral Fellow;posters;pre-doctoral;Process;programs;receptor;Receptor Cross-Talk;receptor function;Receptor Signaling;Regulation;Request for Applications;Research;Research Personnel;Role;Science;Scientist;Signal Transduction;Structure;Structure-Activity Relationship;symposium;Technical Expertise;Techniques;Tissues;tool;Travel;tumor progression;Underrepresented Minority;Universities;Walking;Work


ADMINISTERING_IC: HL

ARRA_FUNDED: N

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Pulmonary Fibrosis;Regenerative Medicine

ORG_CITY: DENVER

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: NATIONAL JEWISH HEALTH

ORG_STATE: CO

PHR: PUBLIC HEALTH RELEVANCE The prevalence of fibrosis is increasing due to the aging population, advances in diagnostic tools and increased exposure to infectious agents and other environmental factors that impact pathogenesis. Understanding the effect of these factors on the clinical manifestation of different fibrosis pathologies and pursing novel advances in lung regeneration after scarring will have a significant impact on lung health. By highlighting emerging concepts of shared relevance to the fields of lung biology and fibrosis and by addressing strategies to improve translation of scientific advances to reduce the burden of fibrosis and other lung diseases, the 2024 Thomas L. Petty Aspen Lung Conference will promote scientific advances in fibrosis biology, fibrosis resolution and therapeutic intervention, ultimately improving lung health.

PI_NAMEs: REDENTE, ELIZABETH FRANCES (contact);SCHWARTZ, DAVID ALBERT

PROGRAM_OFFICER_NAME: GOMEZ, CHRISTIAN RENE

PROJECT_TERMS: Address;aging population;Award;Basic Science;Biology;career;Cells;Cellular biology;Cicatrix;Clinical;Clinical Research;Dedications;Development;Diagnostic;Diagnostic Imaging;diagnostic tool;Discipline;Disease;Disease Progression;diversity and inclusion;early-career faculty;Environmental Risk Factor;epithelial repair;Ethnic Population;Exposure to;Faculty;Fibrosis;fibrotic lung;Future;Generations;Genetic;Grant;imaging approach;improved;Infectious Agent;interest;International;interstitial;Intervention;Intestines;Knowledge;lectures;Lung;Lung Capacity;Lung Diseases;lung health;lung regeneration;lung repair;Measures;Mentorship;Minority;Molecular;novel;novel strategies;novel therapeutic intervention;Oral;Pathogenesis;Pathology;Pathway interactions;Patients;Pneumonia;posters;pre-clinical;Precision therapeutics;Prevalence;Process;Productivity;programs;public health relevance;Publishing;Pulmonary Fibrosis;racial population;Regenerative capacity;repaired;Research;Research Personnel;Resolution;Scientific Advances and Accomplishments;Scientist;Series;structural biology;Structure;success;symposium;Therapeutic Intervention;Translational Research;Translations;Travel;Underrepresented Minority;Usual Interstitial Pneumonia;Woman

PROJECT_TITLE: Aspen Lung Conference Pulmonary Fibrosis - focusing on the future

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-L (J2)]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Genetics;Sarcopenia;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: SALT LAKE CITY

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Narrative Poor muscle recovery following disuse is frequent amongst older adults leading to low muscle mass, weakness, and increased disability. We have proposed to test specific mechanisms of a disrupted macrophage metabolic state during recovery from disuse in aged mice and humans. These findings will produce new knowledge of macrophage metabolism that will aid in the development of therapeutic strategies to promote muscle recovery in aged individuals.

PI_NAMEs: DRUMMOND, MICAH J (contact);O'CONNELL, RYAN M

PROGRAM_OFFICER_NAME: BOYCE, AMANDA T

PROJECT_TERMS: Acceleration;Adopted;age related;aged;Aging;aging population;Anti-Inflammatory Agents;Attenuated;Automobile Driving;bone aging;Bone Marrow;Bone Marrow Cell Transplantation;Bone Marrow Cells;Bone Marrow Transplantation;cell age;Cell Physiology;Cells;Characteristics;Chemicals;Citric Acid Cycle;Classification;Coupled;cytokine;Data;Defect;Development;disability;Disuse Atrophy;Enzymes;Event;Exhibits;experimental study;extracellular;fall risk;falls;Fibrosis;Functional disorder;Future;Genetic;Genetic Transcription;Glycolysis;Growth;Growth Factor;Health;Hematopoietic;Hindlimb Suspension;Human;hypoxia inducible factor 1;Immobilization;Immune system;Impairment;In Vitro;in vivo;Inflammation;Inflammatory;Inflammatory Response;Interleukin-1 beta;Interruption;Invaded;Knowledge;Limb structure;Literature;Long term disability;Macrophage;Macrophage Activation;Mediating;Metabolic;Metabolic Diseases;Metabolism;Methodology;mitochondrial dysfunction;mouse genetics;mouse model;Mus;Muscle;muscle aging;muscle progenitor cell;muscle regeneration;novel;old mice;older adult;Operative Surgical Procedures;Oxidative Phosphorylation;parent grant;Phenotype;pre-clinical;precursor cell;prevent;programs;Recovery;Recovery Support;reduced muscle mass;Regulation;Resolution;response;restoration;Rodent;Role;sarcopenia;Serum;single-cell RNA sequencing;Skeletal Muscle;stem;stem cell function;Stimulus;Succinates;Testing;Therapeutic;therapeutic development;Transcript;transcription factor;transcriptome;Translating;young adult

PROJECT_TITLE: Regulation of macrophage metabolism in aged muscle during recovery


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: BALTIMORE

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Narrative The Neural Control of Movement Society (NCM) will host its 33rd annual meeting in Dubrovnik, Croatia, in April 2024, bringing together several hundred scientists to present and discuss research related to the brain’s control of movement. The meeting covers a broad range of experimental models and modeling approaches, aimed at understanding the neural control of motor behaviors from locomotion, to reaching, to eye movements, to speech. NCM is committed to facilitating trainee attendance at the meeting, and to increasing diversity in terms of gender, underrepresented minorities, and geographical origin, on the podium, in our leadership, and within the NCM society at large.

PI_NAMEs: CULLEN, KATHLEEN E (contact)

PROGRAM_OFFICER_NAME: CHEN, DAOFEN

PROJECT_TERMS: Address;Advertising;Anatomy;Animal Model;Area;Ataxia;Award;Awareness;Behavior;Behavioral;Brain;brain control;Caliber;Canada;career;Caring;Collaborations;commune;Communities;Complex;cost;Country;Croatia;Dedications;design;Development;Disease;Dystonia;Environment;ethnic diversity;Ethnic Origin;Experimental Models;Eye Movements;Faculty;Family;Feedback;Fellowship Program;Fostering;Funding;Future;gaze;Gender;gender diversity;Geography;Glass;Goals;graduate student;Grant;grasp;Group Meetings;Growth;Health;innovation;insight;Institution;interdisciplinary approach;International;Journals;Language;Leadership;Locomotion;meetings;member;Mentors;Mission;Modeling;Molecular;Motor;motor behavior;motor control;motor learning;Movement;Nervous System Disorder;Neurologist;neurophysiology;neuroregulation;Neurosciences;neurotechnology;next generation;Oceans;outreach;Parkinson Disease;Pathway interactions;Positioning Attribute;Postdoctoral Fellow;posters;Posture;programs;Quality of life;Research;Research Personnel;restoration;Role;Schedule;Scholarship;Scientific Advances and Accomplishments;Scientist;Seasons;Sensory;Signal Transduction;social;social media;Societies;sound;spasticity;Speech;Speed;success;System;Time;training opportunity;Tremor;undergraduate student;Underrepresented Minority;United States National Institutes of Health;waiver;Walking;Water;Woman;Writing

PROJECT_TITLE: 2024 Meeting of the Society for the Neural Control of Movement

STUDY_SECTION_NAME: Special Emphasis Panel[ZNS1 SRB-K (43)]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Cocaine;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_DEPT: VETERINARY SCIENCES

PHR: PROJECT NARRATIVE Cocaine misuse is common he heath of the blood brain among people living with HIV (PLWH) and can affect t barrier (BBB), which protects the brain from neurotoxins and pathogens. The disruption of the BBB can lead to higher levels of virus in the brain and poorer cognition. This project combines brain imaging, neuropsychiatric assessments, and blood-based measures of monocyte characteristics, function and reservoir, to understand the role of monocytes play in BBB integrity and health in PLWH who have a history of cocaine misuse.

PI_NAMEs: BERMAN, JOAN WEINBERGER;RUBIN, LEAH HELANE;VEENHUIS, REBECCA TERILLI (contact)

PROGRAM_OFFICER_NAME: BORGMANN, KATHLEEN RUTH

PROJECT_TERMS: Acute;Address;Affect;ALCAM gene;antiretroviral therapy;arterial spin labeling;Biological Assay;Blood;Blood - brain barrier anatomy;blood-brain barrier crossing;blood-brain barrier disruption;blood-brain barrier penetration;blood-brain barrier permeabilization;Brain;Brain imaging;CCL2 gene;CD14 gene;CD4 Positive T Lymphocytes;Cell Adhesion Molecules;cell motility;Cell Surface Proteins;Cells;Central Nervous System;Characteristics;Cocaine;Cocaine misuse;cocaine use;Cocaine use disorder;Cognition;Consequences of HIV;Data;Development;Disease remission;DNA;FCGR3B gene;Frequencies;Health;High Prevalence;HIV;HIV Infections;Human;Imaging technology;Immune;Immunophenotyping;Impaired cognition;Impairment;In Vitro;in vitro Model;in vivo;Individual;Inhalation;innovation;Intravenous;Investigation;Ligands;Link;Macaca;Macrophage;Magnetic Resonance Imaging;Measurement;Measures;Mediating;migration;Modeling;monocyte;neuropsychiatry;Neurotoxins;occludin;pathogen;Peripheral Blood Mononuclear Cell;Persons;Phase;Phenotype;Play;Proviruses;Random Allocation;Recording of previous events;Role;Sampling;Shapes;SIV;small molecule;substance use;Substance Use Disorder;Supporting Cell;T-Lymphocyte;Testing;Therapeutic;Tight Junctions;Vascular Endothelial Cell;Viral;Viral reservoir;Virus;Water

PROJECT_TITLE: Immune mechanisms that shape the blood brain barrier in people living with HIV and cocaine use disorder

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 CEM-N (J1)]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

ORG_CITY: MINNEAPOLIS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: The Academy of Behavioral Medicine Research (ABMR) annual meetings supported by this R13 will provide interactive and engaging forums for established behavioral medicine scientists and thought leaders from diverse scientific disciplines to exchange, discuss, and debate ideas and the latest research advances to promote healthy aging and reduce chronic disease disparities. Topics will include integrative, cutting-edge team science approaches to research as well as dissemination and translational strategies for bringing science to the public and policymakers. This R13 also will support ABMR’s Early-Stage Investigator (ESI) program, bringing a new cohort of diverse ESIs, a majority from groups underrepresented in science and medicine, to the ABMR meeting each year to participate in leadership and career development training, networking, mentoring activities, as well as the full conference program.

PI_NAMEs: EVERSON-ROSE, SUSAN A. (contact)

PROGRAM_OFFICER_NAME: RIDDLE, MELISSA

PROJECT_TERMS: Academy;Advocacy;age related chronic disease;aging mechanism;Alzheimer's Disease;Award;Behavioral Medicine;Behavioral Sciences;Biological;career;career development;Cause of Death;Charge;Chronic Disease;cohort;Collaborations;Communication;Communities;Diabetes Mellitus;disability;Discipline;disease disparity;dissemination strategy;Doctor of Philosophy;Educational workshop;effective intervention;Fellowship;Fostering;Funding;Grant;Health;Health Policy;Healthcare Systems;healthy aging;Heart Diseases;improved;informal atmosphere;innovation;interest;K-Series Research Career Programs;Knowledge;Lead;Leadership;leadership development;life span;Malignant Neoplasms;Medicine;meetings;member;Mentors;Mentorship;Mission;next generation;peer;peer support;Personal Satisfaction;Policy Maker;programs;Public Health;recruit;Renaissance;Research;Research Personnel;Science;Scientific Advances and Accomplishments;scientific atmosphere;Scientist;Senior Scientist;Series;skills;Social Sciences;Structure;success;support network;symposium;Time;Training;Training Programs;translational approach;Underrepresented Populations;United States National Institutes of Health;working group

PROJECT_TITLE: ABMR Annual Meeting 2024 & 2025

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development for Established Investigators and Conference Grants Study Section[AGCD-4]


ADMINISTERING_IC: AA

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Brain Disorders;Prevention;Substance Misuse

ORG_CITY: SAN DIEGO

ORG_DEPT: PSYCHOLOGY

ORG_NAME: SAN DIEGO STATE UNIVERSITY

ORG_STATE: CA

PHR: PROJECT NARRATIVE Alcohol use and misuse is the leading global risk factor for attributable burden of disease among young adults. The International Society for Biomedical Research on Alcoholism (ISBRA) is the premier international organization focused on promoting excellence in alcohol research, and ISBRA Congresses provide an important forum for discussion and collaboration among researchers focused on this serious public health problem. This grant provides support for a diverse group of trainees and early-stage investigators to participate in the conference and engage efforts to address the biomedical, psychosocial, and clinical issues related to alcohol use and misuse.

PI_NAMEs: THOMAS, JENNIFER D (contact)

PROGRAM_OFFICER_NAME: DUNTY, JR, WILLIAM

PROJECT_TERMS: addiction;Address;Age;Alcohol consumption;alcohol misuse;alcohol research;alcohol use disorder;Alcoholism;Alcohols;Americas;Area;Asia;Australia;Biomedical Research;burden of illness;career;Cessation of life;Clinical;Collaborations;Congresses;cost;Country;Destinations;Development;disability;Disabled Persons;Educational workshop;Europe;European;experience;Fostering;Funding;Goals;Grant;Growth;Health Policy;high risk;International;International Agencies;Joints;lectures;Location;meetings;Participant;Persons;posters;premature;Prevention strategy;Process;programs;psychosocial;Public Health;recruit;Research;Research Personnel;Research Project Grants;Risk Factors;Rotation;Schedule;Scientist;Societies;symposium;Training;Travel;treatment strategy;Underrepresented Populations;United States;Update;Woman;Work;young adult

STUDY_SECTION: AA

STUDY_SECTION_NAME: Neuroscience and Behavior Study Section[AA-4]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases;Social Determinants of Health

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE We propose to build the national population-based ASPIRE– ASian American ProspectIve REsearch– Cohort with recruitment of 20,000 males and females, ages 40-75, including focused community-based recruitment from California (San Francisco Bay Area, Sacramento, Los Angeles County, Orange County), New York City/north New Jersey, Philadelphia/south New Jersey (these geographic regions collectively represent over a third of the Asian American population in the United States (US)), but also national outreach to recruit from other US regions. We will apply a transparent and equitable process to inform research priorities and data collection, and disseminate timely, actionable, and policy-relevant study data utilizing interactive data visualization methodologies. In building the first national cancer epidemiologic cohort inclusive of all Asian American populations, ASPIRE will address the research priorities of small populations, intersectionality, and the role of structural and social determinants of health in pathways to cancer risk, including social epigenomics of stress embodiment, health behaviors, and healthcare access.

PI_NAMEs: CHENG, IONA C;GOMEZ, SCARLETT L (contact);SHARIFF-MARCO, SALMA

PROGRAM_OFFICER_NAME: LAM, TRAM K

PROJECT_TERMS: Acclimatization;Acculturation;Address;Adult;advanced analytics;Age;age effect;anti-Asian;Area;Asian Americans;Bangladeshi;California;Cambodian;Cancer Burden;cancer epidemiology;Cancer Etiology;cancer health disparity;cancer initiation;cancer risk;Cause of Death;Censuses;Characteristics;Chinese American;Chronic stress;cohort;Communities;community engaged research;community partners;Complex;Country;County;Data;Data Collection;data sharing;design;Dimensions;Disparate;Environmental Risk Factor;Epidemiology;Epigenetic age;epigenomics;Equity;ethnic identity;Ethnic Origin;Ethnic Population;Exclusion;experience;Feedback;Female;Filipino American;Gender;Genomic DNA;Geographic Locations;Health;Health behavior;health care availability;health equity;Healthcare Systems;high risk;Immigrant;Immigration;Incidence;Institution;interactive visualization;intersectionality;Japanese American;Joints;Korean American;Life;Life Cycle Stages;Lived experience;Los Angeles;Machine Learning;male;Malignant Breast Neoplasm;Malignant neoplasm of liver;Malignant neoplasm of lung;Malignant neoplasm of thyroid;Malignant Neoplasms;malignant stomach neoplasm;marginalized population;Measures;member;men;Mental Health;Methodology;Methods;Modeling;multi-racial;Nasopharynx Carcinoma;never smoking;New Jersey;New York;New York City;novel;Oranges;outreach;Pathway interactions;Patient Self-Report;Pattern;perceived stress;Personal Satisfaction;Phase;Philadelphia;Policies;Population;population based;Population Sizes;Poverty;Process;prospective;racial diversity;racial population;racism;recruit;Research;Research Methodology;Research Personnel;Research Priority;Resources;Risk;Role;saliva sample;San Francisco;Screening for cancer;Sex Orientation;social;social factors;social health determinants;Social status;Socioeconomic Status;southeast Asian;Stress;structural determinants;System;Testing;Trauma;United States;Vision;Woman

PROJECT_TITLE: A national Asian American cohort for assessing multi-level determinants in cancer etiology: the ASPIRE Cohort

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 TCRB-V (J1)]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Cardiovascular;Emerging Infectious Diseases;Genetics;Heart Disease;Immunization;Infectious Diseases;Prevention;Vaccine Related

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

PHR: Enteroviruses are a major source for disease and hospitalization, but currently little is known about their mechanism of infection and there is no available treatment. Using recent advances in single-cell transcriptomics and ultra-deep virus population sequencing, we will explore the dynamics of in vivo enterovirus infection and the host response to it across cells and tissues. Combining these strategies with animal models defective in specific antiviral pathways, we will gain mechanistic insights into viral spread and pathogenesis, which is critical to develop effective antiviral drugs and vaccines.

PI_NAMEs: ANDINO, RAUL  (contact);SIGAL, LUIS J

PROGRAM_OFFICER_NAME: PARK, EUN-CHUNG

PROJECT_TERMS: Acute;Adolescent;Affect;Alleles;Animal Model;Anti-viral Agents;Anti-viral Response;Atlases;Attenuated;Biological;Brain Stem;Cardiomyopathies;cell type;Cells;Clinical;Coxsackie B Viruses;CRISPR/Cas technology;Data;Data Set;deep learning;deep sequencing;Development;Diabetes Mellitus;Disease;emerging pathogen;Encephalitis;Enterovirus;Enterovirus 68;Enterovirus 71;Enterovirus Infections;Evolution;experimental study;Family;Genes;Genetic Determinism;Genetic Structures;Genetic Transcription;Genomics;Goals;Hand, Foot and Mouth Disease;Heart Diseases;Hospitalization;Human;Human poliovirus;Immune response;in vivo;Individual;Infant;Infection;Innate Immune Response;innovative technologies;insight;Interferon alpha;Interferon Type I;Interferon-beta;Interferons;Intervention;Invaded;Knowledge;Lesion;Life;Link;Maps;mathematical model;Measures;Medical;Meningitis;Methods;mouse model;Mus;mutant;Mutation;Myocarditis;Natural Immunity;neonatal sepsis;Nerve Tissue;Neurologic Symptoms;novel;pan-enterovirus;Pancreatitis;Paralysed;Pathogenesis;Pathogenicity;Pathway interactions;Pericarditis;Pharmaceutical Preparations;Phylogenetic Analysis;Population;Population Dynamics;Population Genetics;pressure;prevent;Process;respiratory;Respiratory Signs and Symptoms;response;Reverse engineering;Role;Severities;Shapes;Signal Transduction;single cell analysis;single-cell RNA sequencing;Source;spatiotemporal;Specificity;Structure;Testing;tissue tropism;Tissue-Specific Gene Expression;Tissues;transcriptome;transcriptomics;Tropism;United States;vaccine development;Vaccines;Viral;Virulence;Virus;Virus Diseases;virus genetics;virus host interaction;Virus Replication

PROJECT_TITLE: Mapping spatiotemporal dynamics during enterovirus infection across cells and tissues


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Biotechnology;Regenerative Medicine

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Basement Membranes are extracellular matrices that are defective in a diverse array of human diseases. Knowledge of basement membranes and their cellular receptors is fundamental to our understanding of how multicellular organisms and their tissues are put together and function. This meeting will facilitate the sharing of the latest research and knowledge in the field of basement bembranes among investigators from within and from outside the US and will help to promote collaborations that will speed the tempo of research and move the field forward.

PI_NAMEs: MINER, JEFFREY H;ZENT, ROY  (contact)

PROGRAM_OFFICER_NAME: KOCH, PETER

PROJECT_TERMS: American;Antibodies;Area;Asia;Atmosphere;authority;Award;Basement membrane;Basic Science;Biological;Biological Models;Biological Process;Biological Sciences;Biology;Biotechnology;Cardiovascular system;career;Cell Line;Cells;Clinical Research;Collaborations;collaborative environment;Communication;Data;Dedications;Development;Disease;Educational workshop;Engineering;Environment;Europe;experience;Extracellular Matrix;Faculty;Feedback;Fees;Female;Fibrosis;Fostering;Funding;Funding Mechanisms;Goals;graduate student;human disease;In Vitro;in vivo;interest;International;Knowledge;Leadership;male;Malignant Neoplasms;Mechanics;Medical center;medical schools;meetings;membrane assembly;minority scientist;minority trainee;Mission;Muscle Development;Neoplasm Metastasis;nephrogenesis;novel;organ regeneration;organ repair;Organism;Pathogenesis;peer;Pharmacologic Substance;Postdoctoral Fellow;pre-doctoral;Productivity;programs;Reagent;receptor;Research;Research Personnel;Scientist;Series;Signal Pathway;skin organogenesis;Societies;Speed;Stem Cell Research;Structure;Thinking;tissue regeneration;Tissues;Transcend;Transgenic Animals;translational potential;Travel;Underrepresented Minority;United Kingdom;United States National Institutes of Health;Universities;Washington;Woman;Work

PROJECT_TITLE: 2024 American Society for Matrix Biology (ASMB) Workshop on Basement Membranes

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


NIH_SPENDING_CATS: Aging

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: NARRATIVE  This application requests partial funding for the 2024 5th Symposium of the Midwest Aging Consortium (MAC). The conference will be held on April 28-30, 2024, at the Blackwell Hotel on the Ohio State University campus in Columbus, OH. According to the census in 2020, 55.8 million or 16.8% of the population of the United States in 2020. This MAC symposium brings together top scientists from multiple disciplines and institutions to advance this vital field while striving for an inclusive meeting that actively involves junior scientists.

PI_NAMEs: MIHAYLOVA, MARIA M.;MORA, ANA LUCIA;ROJAS, MAURICIO  (contact)

PROGRAM_OFFICER_NAME: OROSZ, ANDRAS

PROJECT_TERMS: age-related disease;Aging;aging biomarker;aging mechanism;Award;biological adaptation to stress;Biology of Aging;career;Cell Aging;Cellular biology;Censuses;Chicago;Chronic Disease;Clinic;Clinical;Collaborations;collaborative environment;Data;design;Development;Diagnosis;Discipline;Disease;disorder prevention;Doctor of Philosophy;Ensure;Environment;Event;Exercise;Faculty;Fostering;Funding;Future;Genetic;Geriatrics;Goals;Health Professional;Healthcare;human old age (65+);Illinois;Immune;Indiana;Infrastructure;Institution;Interdisciplinary Study;interest;Investigation;Iowa;Lead;Learning;Link;Malignant Neoplasms;Medical;Medicine;meetings;member;Metabolism;Michigan;Midwestern United States;Minnesota;Mission;Molecular;multidisciplinary;North Dakota;novel strategies;Ohio;Oral;Participant;Pathogenesis;Persons;Physicians;Population;Postdoctoral Fellow;posters;Predisposition;programs;Public Health;Regenerative response;repaired;Request for Applications;Research;Research Personnel;Resource Sharing;Science;Scientific Advances and Accomplishments;Scientist;senior faculty;Series;Students;symposium;Time;translational physician;translational scientist;Travel;undergraduate student;United States;United States National Institutes of Health;Universities;Wisconsin;Woman

PROJECT_TITLE: 5th Annual MAC (Midwest Aging Consortium) Aging Research Symposium


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lead Poisoning;Machine Learning and Artificial Intelligence;Neurodegenerative;Neurosciences;Prevention;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: Project Narrative Mount Sinai’s Institute for Exposomic Research proposes a series of 5 annual symposia on Exposomics, Aging and Alzheimer’s disease and Related Dementias(ADRD). Meetings will be held internationally with co-host institutions (see letters of collaboration) in Japan, Mexico, France, Rwanda and in the U.S. at Meharry Medical College. The symposia are designed to promote diverse research in exposomics in ADRD globally.

PI_NAMEs: MORRISON, R. SEAN;WRIGHT, ROBERT O (contact)

PROGRAM_OFFICER_NAME: KWOK, RICHARD K

PROJECT_TERMS: Acceleration;Address;Adult;Adverse event;Aging;Air;All of Us Research Program;Alzheimer's Disease;Alzheimer's disease related dementia;Artificial Intelligence;Award;Back;big-data science;Biogenesis;Biological Assay;Biological Markers;Biological Models;bone lead;Brain;built environment;career;Chemicals;Child;Childhood;climate-related health;clinical care;Collaborations;community partners;Complex;Country;Coupled;critical period;Data;data mining;Databases;Dementia;dementia risk;design;Developing Countries;Development;Disease;Disparity;Educational workshop;effective therapy;Elderly;Environment;Environmental Exposure;Environmental Risk Factor;equity, diversity, and inclusion;Europe;Evaluation;experience;Exposure to;Faculty;fetal;Fostering;France;Funding;Future;Gasoline;gene environment interaction;Genetic;Genetic Research;Geographic Locations;Goals;Government;Growth;Health;health disparity;Heritability;Historically Black Colleges and Universities;improved;Income;insight;Institution;International;Intervention;Japan;Knowledge;late life;Latin America;Lead;lead exposure;lead paint;Letters;Life;Life Cycle Stages;Link;Location;Longevity;Machine Learning;Maps;Measures;medical schools;meetings;Memory Loss;Mental Depression;Metals;Mexico;Mining;minority scientist;Modeling;multidimensional data;Nerve Degeneration;neurotoxic;novel;nutrition;pandemic disease;Participant;Pathway interactions;Pesticides;Photography;Physiological;Plasticizers;Police;Policies;Policy Maker;Pollution;Population Study;Positioning Attribute;posters;Poverty;Pregnancy;Prevalence;Prevention;Prevention Measures;Process;programs;remote sensing;Research;Research Methodology;Research Personnel;Role;Rwanda;satisfaction;Scholarship;Science;Scientist;Series;Shapes;small molecule;social;social media;socioeconomic disadvantage;Stress;Students;Surveys;symposium;Technology;Time;Tooth structure;Training;Travel;Twin Multiple Birth;Underrepresented Minority;underserved minority;United States National Institutes of Health;War;wearable device;Weather

PROJECT_TITLE: Exposomics and Alzheimer's disease Across the Life Course


NIH_SPENDING_CATS: Neurosciences

ORG_CITY: East Greenwich

ORG_NAME: GORDON RESEARCH CONFERENCES

ORG_STATE: RI

PHR: Project Narrative The basal ganglia are a group of brain structures involved in movement and motivation, with dysfunction resulting in devastating human diseases including Parkinson’s disease, Huntington’s disease, dystonia, addiction, obsessive compulsive disorder, and Tourette’s syndrome. To better understand and treat these diseases, support for a conference dedicated to basic, translational, and clinical basal ganglia research is sought. A diverse group of attendees will meet to present and discuss recent fundamental discoveries, and to educate and inspire early career basal ganglia researchers to increase understanding of basal ganglia function and dysfunction and facilitate translation of this knowledge to the clinic.

PI_NAMEs: WITTEN, ILANA  (contact)

PROJECT_TERMS: Acceleration;addiction;Address;Basal Ganglia;Basic Science;Brain;Brain region;career;cell type;Child Care;Clinic;Clinical;Clinical Research;clinically relevant;Cognition;Collaborations;collaborative environment;Communities;Computer Models;Country;Decision Making;Dedications;design;Development;Disease;Dystonia;Education;Equilibrium;Event;Evolution;Freezing;Functional disorder;Gait;Gender;Gilles de la Tourette syndrome;Goals;Health;Hearing;Hour;human disease;Huntington Disease;innovation;interest;International;knowledge translation;Leadership;lectures;Link;meetings;Mentors;Minority;Mission;Modeling;Motivation;Movement;next generation;Obsessive-Compulsive Disorder;Parkinson Disease;Participant;Postdoctoral Fellow;posters;pre-doctoral;programs;Psychomotor Disorders;Research;Research Personnel;Resources;Role;Scientist;social;Societies;Structure;Students;symposium;Thinking;Time;tool;Translations;Travel;United States National Institutes of Health;unpublished works;Woman;Work

PROJECT_TITLE: 2024 Basal Ganglia Gordon Research Conference and Gordon Research Seminar


ADMINISTERING_IC: EB

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Nanotechnology;Obesity

ORG_CITY: CHAMPAIGN

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

ORG_STATE: IL

PHR: NARRATIVE Classification of cells within human tissues is essential for understanding states of health and disease. In this proposal, we will develop a new class of fluorescent label that increases the number of molecular classification markers for cells by an order of magnitude. These labels function within intact, three-dimensional tissue, an attribute that we will use to map the local environments of adipose tissue immune cells that are thought to determine comorbid outcomes of obesity.

PI_NAMEs: SMITH, ANDREW MICHAEL (contact)

PROGRAM_OFFICER_NAME: ATANASIJEVIC, TATJANA

PROJECT_TERMS: 3-Dimensional;Address;Adipose tissue;Animal Model;Applications Grants;Biological;Biomedical Engineering;biomedical imaging;Categories;cell dimension;cell type;Cells;Cellular Immunology;Classification;comorbidity;Computer software;deep learning algorithm;design;Disease;Electronics;Engineering;Environment;Exhibits;Fluorescence;fluorophore;Goals;Health;Heart Diseases;human tissue;Image;Immune;Immunoglobulin Fragments;Label;Light;Maps;Microscope;Microscopy;Molecular;molecular marker;Molecular Probes;nanocrystal;Nature;Non-Insulin-Dependent Diabetes Mellitus;Obesity;optical imaging;Optics;Outcome;Pattern;Property;Proteomics;Quantum Dots;Research Personnel;Research Project Grants;Resolution;Rodent Model;Scientist;Semiconductors;Specificity;Stains;Technology;Thick;Thinness;Time;Tissues;tool;tumor-immune system interactions

PROJECT_TITLE: Hyperplexed Quantum Dots for Multidimensional Cell Classification in Intact Tissue


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Rare Diseases;Valley Fever

ORG_CITY: SAN ANTONIO

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF TEXAS SAN ANTONIO

ORG_STATE: TX

PHR: Narrative Coccidioides spp. are the causative agents of coccidioidomycosis, also known as Valley fever which is an emerging infection with ~380,000 new cases in the US annually. Many important questions needed to be studied for the development of better therapeutic strategies for the control of this mycosis. It is the first time, we request NIH R13 funds to support travel awards for trainees, travel costs for a keynote speaker, and to defray the cost of live streaming for an annual meeting to reach more researchers interested in Coccidioides and Valley Fever.

PI_NAMEs: HUNG, CHIUNG-YU  (contact)

PROGRAM_OFFICER_NAME: MULACH, BARBARA L

PROJECT_TERMS: Address;anti-fungal agents;Arizona;Award;Awareness;Basic Science;Businesses;California;career;Career Choice;Cities;Clinical;Coccidioides;Coccidioidomycosis;Collaborations;college;cost;Data;demographics;desert fever;Development;Disease;diversity and inclusion;Drug resistance;Education;Emerging infection;Environment;Epidemiologist;ethnic diversity;Ethnic Origin;Faculty;Feedback;Funding;Future;Goals;graduate student;Grant;Group Meetings;Health Personnel;Hispanic;Hour;Human;improved;Institution;interest;Laboratories;Learning;live stream;Longevity;Medical;meetings;member;Mentors;Mexico;minority trainee;Mission;National Institute of Allergy and Infectious Disease;Oral;Persons;Physicians;Postdoctoral Fellow;posters;Program Development;programs;Race;Research;Research Personnel;Rotation;Scientist;Site;Societies;socioeconomic diversity;South America;Students;symposium;synergism;Texas;The science of Mycology;Therapeutic;therapeutic development;Time;tool;Training;Translational Research;Travel;undergraduate student;United States;United States National Institutes of Health;Universities;Vaccines;Veterinarians;Woman;Work

PROJECT_TITLE: Support for the 68th  annual meeting of Coccidioidomycosis study group

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 LK-D (J1)]


NIH_SPENDING_CATS: Aging;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human;Stem Cell Research - Nonembryonic - Human

ORG_CITY: Rockville

ORG_NAME: SOCIETY FOR MUSCLE BIOLOGY

PHR: PROJECT NARRATIVE Skeletal muscle stem cells, also known as satellite cells, are responsible for the remarkable regenerative properties of skeletal muscle and are of very high interest to the scientific community as their study has produced major insights into muscle biology and stem cell behavior generally. This conference, the only one dedicated to this topic, will bring together international leaders in the field, as well as graduate students, postdoctoral researchers, junior faculty, and stem cell biologists from other systems to present and discuss unpublished work in this fast-moving, cutting-edge field. Therefore, this conference has high relevance for human health, as these advances and new ones that will proceed from them will drive work in muscle growth, repair, disease and aging.

PI_NAMEs: MILLAY, DOUGLAS PAUL (contact)

PROGRAM_OFFICER_NAME: LINDHURST, MARJORIE JEAN

PROJECT_TERMS: Adult;Aging;Area;Attention;Biology;Biomedical Engineering;bone;Canada;career;Career Choice;career development;career networking;cell behavior;Cell Communication;Cell fusion;cell type;Cells;Collaborations;collaborative environment;Communities;Complex;Data;Dedications;Development;Disease;disease model;Educational workshop;Engineering;Ensure;Equilibrium;Evaluation;Exercise;Faculty;Fertilization;Fostering;Friends;Future;Gender;Genetic Transcription;Geography;Goals;graduate student;Growth;Health;Homeostasis;Human;Hypertrophy;Individual;Injections;insight;interest;International;meetings;Mentors;Minority;Molecular;Muscle;muscle aging;Muscle Development;muscle engineering;Muscle function;muscle progenitor cell;muscle regeneration;Muscle satellite cell;Myopathy;Natural regeneration;Nervous System;Neuromuscular Junction;new technology;novel;Oral;Organoids;Participant;Physiological;Policies;Postdoctoral Fellow;posters;Prize;Productivity;programs;Property;Quebec;Recording of previous events;regenerative;Regenerative capacity;Regulation;repaired;Research;Research Personnel;Running;Science;Scientist;senescence;single nucleus RNA-sequencing;Skeletal Muscle;Slide;Societies;stem cell aging;stem cell therapy;stem cells;Structure;Surveys;symposium;System;targeted treatment;therapeutic development;Therapeutic Intervention;Tissues;tool;Translating;Underrepresented Minority;Underrepresented Populations;unpublished works;virtual;Woman;Work

PROJECT_TITLE: Skeletal Muscle Stem Cells in Development, Regeneration, and Adaptations


ORG_DEPT: PATHOLOGY

PHR: Project Narrative The Woods Hole Immunoparasitology Meeting (WHIP) brings together scientists who study many neglected tropical diseases of the world, and the parasitic diseases endemic in the United States. The exchange of information and ideas that occur at this meeting will advance the development of new treatments for these diseases.

PI_NAMEs: FAIRFAX, KEKE CELESTE (contact)

PROGRAM_OFFICER_NAME: STRICKLER-DINGLASAN, PATRICIA M

PROJECT_TITLE: Woods Hole Immunoparasitology Meeting (WHIP) 2023


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Cancer;Digestive Diseases;Eye Disease and Disorders of Vision;Genetics;Liver Disease;Mental Health;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: LOS ANGELES

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative  The ASXL-Related Disorders Scientific Conference and Family Meeting will serve to increase medical and scientific knowledge about syndromes caused by variants in the ASXL genes and to improve the quality of medical care provided to these individuals. By improving clinical management of these systemic, neurocognitive disorders, the aim is to decrease suffering and increase quality of life for impacted individuals and their families.

PI_NAMEs: RUSSELL, BIANCA  (contact);TAN, WEN-HANN

PROGRAM_OFFICER_NAME: SURPRIS, MARIPIERRE PAYEN

PROJECT_TERMS: Adult;Advertising;Affect;Anxiety;Apraxia;Attention deficit hyperactivity disorder;auditory processing;autism spectrum disorder;Baltimore;Behavior Disorders;Behavioral;Biological;Biological Markers;Body System;Bohring syndrome;cancer risk;Caring;cerebral visual impairment;Child;Child Development;Cholelithiasis;Chromatin;Chronic;Clinical;Clinical assessments;clinical care;clinical infrastructure;Clinical Management;Clinical Research;clinical translation;clinical trial readiness;Clinical Trials;Code;Cognition;Collaborations;Communities;Congenital Abnormality;Data;data sharing;Databases;Disease;drug development;Dysautonomias;Dysplasia;Epigenetic Process;Epilepsy;Equity;Event;Failure;Family;Family health status;Family member;family support;feeding;Fortification;Fostering;gastrointestinal;Gastrointestinal tract structure;Genes;Genetic Diseases;Genetic Transcription;Goals;Grant;Growth;Health;Hepatoblastoma;histone modification;Homeobox Genes;improved;Individual;insight;Intellectual functioning disability;interest;International;Intestines;Knowledge;Language;Learning;Life;life span;live stream;Medical;meetings;Mental Health;Minority Groups;Mission;motility disorder;Muscle hypotonia;Myopia;National Center for Advancing Translational Sciences;National Institute of Child Health and Human Development;National Institute of Diabetes and Digestive and Kidney Diseases;National Institute of Neurological Disorders and Stroke;National Institute on Deafness and Other Communication Disorders;Natural History;Nephroblastoma;neurocognitive disorder;Neurologic;next generation;non-verbal;Optic Nerve;Pathogenicity;Personal Satisfaction;Persons;Postdoctoral Fellow;posters;Quality of life;rare genetic disorder;Reader;recruit;Regulation;Research;Research Personnel;research study;Resources;Retina;Retinal Defect;Risk;Role;safety net;sample collection;Sampling;Scholarship;Scientist;Seizures;Speech;Students;symposium;Syndrome;System;targeted treatment;Therapeutic Trials;tool;Travel;United States National Institutes of Health;Variant;Vision;Vomiting;Weight Gain

PROJECT_TITLE: 2024 ASXL-Related Disorders Scientific Conference and Family Meeting

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Developmental Biology Study Section[CHHD-C]


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Complementary and Integrative Health

ORG_CITY: Lake Oswego

ORG_NAME: ACADEMIC CONSORTIUM FOR INTEGRATIVE MEDICINE AND HEALTH, INC.

ORG_STATE: OR

PHR: PROJECT NARRATIVE Public scientific conferences where new peer-reviewed work is presented and discussed are crucial to the advancement of all research disciplines. These conferences allow scientists, regulators, funders, and researchers-in-training to come together in a focused setting to explore data from important recent work in their respective disciplines, address issues of common concern, and provide much-needed peer review regarding the emerging knowledge and understanding. The general public benefits enormously and is impacted by way of the improved therapeutic and other scientific advances that make their first appearance at these conferences. NIH’s support of this particular scientific conference has been critical in allowing the extension of benefits of attending to a larger and more diverse audience—in particular, students and fellows in training.

PI_NAMEs: COTTON, SIAN  (contact);SIMMONS, SAMANTHA

PROGRAM_OFFICER_NAME: BELFER, INNA

PROJECT_TERMS: Active Learning;Address;Appearance;Australia;Award;Basic Science;Brazil;Budgets;Canada;career;career development;catalyst;Cities;Clinical;clinical care;Clinical Services;Collaborations;Collection;Communication;Communities;Complementary Health;Congresses;cost effectiveness;Country;Data;Development;Discipline;discount;dissemination science;Education;Educational Models;Educational workshop;Evaluation;Event;expectation;Feedback;Funding;Future;General Population;global health;Goals;Grant;Growth;Health;Health Professional;Health Services;Health system;Healthcare;implementation science;improved;Individual;Institution;Integrative Medicine;Integrative Therapy;International;Knowledge;Life Style;Medical;Medical Research;Medicine;meetings;member;Mentors;Mexico;Modeling;Names;National Center for Complementary and Integrative Health;Oral;Outcome;outreach;Participant;Peer Review;Policies;posters;Process;Professional Education;programs;Request for Applications;Research;Research Personnel;Research Priority;Safety;Scholarship;Science;Scientific Advances and Accomplishments;Scientist;Seasons;Shapes;Sodium Chloride;Strategic Planning;student conference;Students;symposium;System;Therapeutic;Training;Travel;undergraduate student;Underrepresented Populations;United States National Institutes of Health;whole health;Work

PROJECT_TITLE: 2024-2028 Annual International Congress on Integrative Medicine and Health (ICIMH)

STUDY_SECTION_NAME: Special Emphasis Panel[ZAT1 AM (04)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);American Indian or Alaska Native;Brain Disorders;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research

ORG_CITY: CHICAGO

ORG_NAME: ALZHEIMER'S ASSOCIATION

PHR: PROJECT NARRATIVE Dementia is the primary cause of disability and dependency worldwide. In the United States, minoritized populations - including African Americans, American Indians/Alaska Natives and Hispanic/Latino individuals - are more likely to develop dementia than non-Latino Whites and Asian Americans. This is in part due to the historic exclusion of these populations from research into Alzheimer’s and all other Dementias (ADRDs). The proposed conferences and workshops will bring together established and early career researchers to examine these existing disparities through a health equity lens, catalyze vital conversations between researchers at all levels, provide valuable mentorship and networking opportunities and will build on the successes of the previous conferences.

PI_NAMEs: CARRILLO, MARIA C (contact);MAESTRE, GLADYS E.;TRAMUJAS VASCONCELLOS NEUMANN, LYCIA

PROGRAM_OFFICER_NAME: PERCY-LAURRY, ANTOINETTE LOIS

PROJECT_TERMS: Address;African American population;Alaska Native;Alzheimer's Disease;American Indians;Asian Americans;Awareness;Biological Factors;career;caucasian American;Collaborations;Communities;Data;Data Set;Dedications;Dementia;dementia risk;Dependence;design;Diagnostic;disability;Disparity;Educational workshop;Ensure;Evaluation;Exclusion;Feedback;Funding Agency;Future;Geography;health disparity;health equity;Health equity research;Hispanic;Hispanic-serving Institution;Hybrids;Infrastructure;innovation;International;Journals;Latino Population;lectures;Life Cycle Stages;Location;Manuscripts;Mentorship;Methods;Minority Groups;Modification;Names;National Institute on Aging;Peer Review;Persons;Population;posters;programs;Publishing;Research;Research Personnel;Science;Scientific Advances and Accomplishments;skills training;structural determinants;success;symposium;Texas;Thinking;Underserved Population;United States;Universities;virtual

PROJECT_TITLE: Alzheimer’s Association International Conference (AAIC) Advancements: Towards Health Equity in Alzheimer’s andall other Dementias


ORG_CITY: Newton Highlands

ORG_NAME: AMERICAN SOCIETY FOR NEUROCHEMISTRY

ORG_STATE: MA

PHR: Project Narrative The goal of the 54th Annual Meeting of the American Society for Neurochemistry (ASN) to be held April 14-18, 2024 in Portland, Oregon is to bring together members of the scientific community to bridge and cross-fertilize the fields of neurochemistry and neuroscience. It is imperative to provide early career investigators and trainees, who will ultimately make up the next generation of investigators, with a forum for the open and free exchange of ideas. This objective, and the stated goal of further reaching underrepresented groups, is fostered by the highly specialized, topical, and interactive organizational format of the ASN meeting.

PI_NAMEs: NICHOLS, MICHAEL R. (contact)

PROGRAM_OFFICER_NAME: TYLER, WILLIAM A

PROJECT_TERMS: American;Award;Awareness;Biochemical;Blood - brain barrier anatomy;Brain;Brain Diseases;brain metabolism;career;career development;Caring;cell type;Cells;Cellular biology;Cellular Neurobiology;Central Nervous System;childcare allowance;Collaborations;Communication;Communities;cost;design;Development;Disabled Persons;disadvantaged background;Discipline;Disease;Disparity population;Doctor of Philosophy;Education;educational atmosphere;Educational workshop;Ethnic Population;Evaluation;Event;experience;Faculty;Family;Feedback;Fees;Fellowship;Female;Financial Support;Fostering;Funding;Future;genetic profiling;Goals;Grant;high school;Homeostasis;Image;Immune system;Individual;Industry;Inflammatory;investigator training;Marketing;meetings;member;Mentors;Mentorship;Metabolism;Molecular;Molecular Neurobiology;Nerve Degeneration;Nervous System;nervous system development;Nervous System Disorder;Nervous System Physiology;Neurobiology;neurochemistry;neurodevelopment;Neurodevelopmental Disorder;Neuroglia;neuroinflammation;Neurologic;Neurosciences;new therapeutic target;next generation;novel therapeutics;Occupations;Oral;Oregon;Organoids;Participant;Peripheral Nervous System Diseases;Pharmacologic Substance;Postdoctoral Fellow;posters;Process;Productivity;Program Development;programs;Public Health;racial population;recruit;repaired;Research;Research Personnel;Running;Science;Scientist;Secure;Site;Societies;Source;stem cells;Students;symposium;System;Therapeutic;Time;Training;Travel;Underrepresented Minority;Underrepresented Populations;United States National Institutes of Health;Update;Woman

PROJECT_TITLE: The 54th Annual Meeting of the American Society for Neurochemistry


NIH_SPENDING_CATS: Biomedical Imaging;Clinical Research;Lung;Organ Transplantation;Prevention;Transplantation

ORG_CITY: PHILADELPHIA

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Narrative This project seeks to use hyperpolarized xenon-129 MRI to establish a set of imaging markers capable of detecting the early onset of chronic lung allograft dysfunction (CLAD) in lung transplant recipients before current diagnostic techniques are capable of registering a clinically significant decline in function. Despite dramatically improved rates of early survival, long-term mortality after lung transplantation, of which CLAD is the leading cause, remains distressingly high. Earlier diagnosis of suspected CLAD currently represents the only viable path to extending the window for effective therapeutic intervention.

PI_NAMEs: RIZI, RAHIM R (contact)

PROGRAM_OFFICER_NAME: CHARYA, ANANTH VELUGALETI

PROJECT_TERMS: Acceleration;Acids;aggressive therapy;Air;airway obstruction;Allografting;Alveolar;Antibodies;aspirate;Bilateral;Binding;Biopsy;Blood flow;Bronchiolitis Obliterans;Cause of Death;Cessation of life;Characteristics;Chronic;Chronic Obstructive Pulmonary Disease;Classification;Clinical;clinical diagnosis;clinical phenotype;Clinical Trials;clinically significant;Diagnosis;Diagnostic Imaging;Diagnostic Procedure;Diagnostic Sensitivity;Diagnostic Specificity;Diffusion;Disadvantaged;Disease;Disease Progression;Distress;Drops;Early Diagnosis;Early Intervention;early onset;Failure;Fibrosis;follow-up;Frequencies;functional decline;Functional disorder;Future;Gases;Gastroesophageal reflux disease;Hemoglobin;Heterogeneity;Human;Image;imaging biomarker;imaging modality;Immunologics;Impairment;improved;Infection;Injury;insight;Institution;Intervention;Localized Disease;Lung;lung allograft;Lung Transplantation;Magnetic Resonance Imaging;Measurement;Measures;Mediating;mortality;Nature;neutrophil;novel;Obstruction;Onset of illness;Oxygen;Patients;Peripheral;Phase;Phenotype;post-transplant;predictive marker;Prognostic Marker;Prophylactic treatment;Protocols documentation;pulmonary function;Pulmonary Function Test/Forced Expiratory Volume 1;Pulmonary function tests;Pulmonary Gas Exchange;Radiology Specialty;recruit;Reflux;Reperfusion Injury;Research Personnel;Respiratory Tract Infections;response;Risk Factors;routine imaging;Specificity;Spirometry;Staging;Structure;Structure of parenchyma of lung;Survival Rate;Syndrome;Techniques;Therapeutic Intervention;therapeutically effective;Tidal Volume;Tissues;Transplant Recipients;Transplantation;ventilation;Visit;Work;X-Ray Computed Tomography;Xenon

PROJECT_TITLE: Predicting the onset of chronic rejection in lung transplant recipients using hyperpolarized 129Xe imaging


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cocaine;Drug Abuse (NIDA only);Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: PITTSBURGH

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Narrative: Substance Use Disorder (SUD) is a brain disorder with increasing prevalence across socioeconomic and generational classes with no effective treatment. The objectives of the proposed research are to determine the role of an underexplored cell-type, astroglia, in the regulation of cue-induced synaptic changes and cue-induced cocaine seeking. The expected results will provide a novel angle to understanding NAc-based addictive behaviors, and a potential cellular target for treating SUD.

PI_NAMEs: ZINSMAIER, ALEXANDER  (contact)

PROGRAM_OFFICER_NAME: FALCON-MORALES, EDGARDO

PROJECT_TERMS: Abstinence;Acute;addiction;Addictive Behavior;AMPA Receptors;Anatomy;Astrocytes;Behavior;Brain Diseases;cell type;cellular targeting;Cocaine;cocaine exposure;cocaine relapse;cocaine reward;cocaine seeking;cocaine self-administration;Cocaine withdrawal;Complex;Cues;Data;designer receptors exclusively activated by designer drugs;Disease;drug abstinence;drug induced behavior;drug seeking behavior;Drug Targeting;drug withdrawal;effective therapy;Emotional;Epidemic;experience;experimental study;Exposure to;Generations;Glutamates;improved;In Vitro;in vivo;Knowledge;Learning;Link;Mediating;Memory;memory consolidation;memory retrieval;Modeling;Monitor;Motivation;Mus;Neuroglia;Neurons;novel;Nucleus Accumbens;Outcome;Output;Permeability;Pharmaceutical Preparations;pharmacologic;Play;Prevalence;prevent;Process;recruit;Regulation;Relapse;Research;Retrieval;Rodent;Rodent Model;Role;Self Administration;Shapes;Signal Transduction;socioeconomics;Substance Use Disorder;Synapses;Synaptic Transmission;Testing;Therapeutic;Thrombospondins;tool;Transgenic Mice;transmission process;United States;Up-Regulation;Viral;Virus;Withdrawal

PROJECT_TITLE: Astrocyte-mediated regulation of cocaine-generated synapses during cocaine seeking


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Genetics;Kidney Disease;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: CLEVELAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

PHR: PROJECT NARRATIVE . African Americans have an increased risk of kidney disease in part due to two variants within the APOL1 gene, but mechanism for this disease is unknown. As APOL1 is only found in humans and some primates, this study will use a human based research model to study the possible underlying mechanisms of kidney disease.

PI_NAMEs: HAINES, LAUREN ELIZABETH (contact)

PROGRAM_OFFICER_NAME: MARIC-BILKAN, CHRISTINE

PROJECT_TERMS: Adult;Affect;African;African American population;African Trypanosomiasis;Alleles;Amino Acids;Animal Model;Apolipoproteins;Belief;biological adaptation to stress;Biology;C-terminal;Cell Line;Cell model;cell type;Cells;Cessation of life;Chronic Kidney Failure;Consumption;Coupled;curative treatments;Cytoplasm;Cytoskeleton;cytotoxic;cytotoxicity;Data;Development;Dialysis procedure;directed differentiation;Disease;Disease Progression;End stage renal failure;Epithelium;European;Exhibits;Experimental Designs;Exposure to;Filtration;Foot Process;Functional disorder;Genes;Genetic Engineering;Genotype;Glomerular Capillary;Goals;health disparity;Heterozygote;high risk;HIV;Human;human induced pluripotent stem cells;Hypertension;Impairment;in vivo;Incidence;Individual;induced pluripotent stem cell;injured;Injury;Injury to Kidney;Kidney;kidney allograft;Kidney Diseases;Kidney Transplantation;Knowledge;Link;Liquid substance;Maintenance;Mediating;migration;Modeling;non-diabetic;novel;overexpression;Pathogenicity;Pathology;Patients;Physiological;podocyte;Point Mutation;Population;Primates;Process;Proteins;Protocols documentation;Quality of life;Renal function;Renal glomerular disease;Research;resistance allele;Resort;response;Risk;risk variant;Series;Signal Pathway;slit diaphragm;stressor;Structure;Therapeutic Intervention;Time;transcriptome sequencing;United States;Urine;Variant;Virus Diseases;wasting;Work

PROJECT_TITLE: Human iPSC-derived Podocytes to Study APOL1 High-Risk Variants


ORG_CITY: BOSTON

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

PHR: Project Narrative The overall goal of this project is to develop a highly specific cell targeting technology to selectively eliminate the autoreactive T cells implicated in the destruction of islet beta cells in type 1 diabetes (T1D) , thus removing the source of the autoimmunity without causing systemic immunsuppression. Our approach is to repurpose CAR T cells, which has shown tremendous clinical efficacy against blood cancers, to attack multiple autoreactive T cells through antigen-specific TCR targeting. Successful completion of this work will provide a paradigm-shifting treat- ment for T1D.

PI_NAMEs: BIRNBAUM, MICHAEL ;CETRULO, CURTIS LISANTE;KENT, SALLY CHOATE;WONG, WILSON  (contact)

PROGRAM_OFFICER_NAME: BLONDEL, OLIVIER

PROJECT_TERMS: Address;Affinity;Animal Model;antigen binding;Antigen Targeting;Antigens;Autoantigens;Autoimmune Diseases;Autoimmune Responses;Autoimmunity;autoreactive T cell;autoreactivity;Beta Cell;Binding;Biological Models;Blood Glucose;CAR T cell therapy;cell killing;Cell Separation;Cell Therapy;Cells;chimeric antigen receptor;chimeric antigen receptor T cells;Clinical;clinical efficacy;clinical implementation;Collaborations;Collection;Core Facility;Data;design;Diabetic mouse;Engineering;Epitopes;exhaustion;Experimental Designs;experimental study;Failure;flexibility;Future;Goals;Hematologic Neoplasms;Hematopoietic Neoplasms;Human;Human Cloning;humanized mouse;Immune mediated destruction;Immune system;Immune Targeting;Immunology;Immunosuppression;improved;In Vitro;in vitro Assay;in vivo;Insulin-Dependent Diabetes Mellitus;islet;Islet Cell;Ligands;Maps;Memory;Modeling;Mus;novel;Outcome;Patients;Peptide/MHC Complex;Peptides;Performance;prevent;Reagent;recruit;Signal Transduction;Source;Specificity;Specimen;standard care;Structure;synthetic biology;System;T cell infiltration;T-Lymphocyte;Techniques;Technology;Testing;Work

PROJECT_TITLE: Precise targeting of T1D specific T cells using CAR and peptide-MHC chimeric antigen ligands


NIH_SPENDING_CATS: Aging;Biotechnology;Cardiovascular;Clinical Research;Genetics;Heart Disease;Human Genome;Physical Activity;Prevention

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: Project Narrative Heart failure with preserved ejection fraction (HFpEF) disproportionately burdens elders and African Americans causing substantial morbidity and mortality, and has no effective treatment making it an especially pressing public health concern. This project will take the novel approach of investigating biologic pathways that mediate cardiac resilience in these high-risk populations by relating proteomics (4,931 circulating proteins) to exercise hemodynamics, longitudinal changes in cardiac function, and detailed genomics. In identifying new targets for interventions promoting cardiac health to prevent HFpEF, this project will also support the expansion of Dr Shah's patient oriented research program and enhance the quality and breadth of training for his mentees.

PI_NAMEs: SHAH, AMIL M (contact)

PROGRAM_OFFICER_NAME: WEBB, STEPHANIE JOHNSON

PROJECT_TERMS: Affect;African American population;Ancillary Study;aptamer;Atherosclerosis Risk in Communities;Biological;candidate identification;Cardiac;Cardiac health;cardioprotection;cardiovascular imaging;Cardiovascular Physiology;cardiovascular risk factor;Cardiovascular system;career;Characteristics;Clinical;clinical investigation;cohort;comorbidity;Computational Biology;Coronary heart disease;Data;Databases;Diagnosis;Disease;Dyspnea;Early Diagnosis;Educational workshop;effective therapy;EFRAC;Elderly;Enrollment;Epidemiology;Ethnic Origin;Exercise;Exercise Test;Frequencies;Functional disorder;Funding;Genetic;Genetic Determinism;genetic variant;Genetic Variation;genome sequencing;genomic data;Genomics;Goals;Grant;Heart failure;heart function;heart imaging;heart preservation;hemodynamics;Heterogeneity;high dimensionality;high risk population;Hospitals;Image;imager;Impairment;improved;Individual;Innovative Therapy;Intervention;Investigation;Jackson Heart Study;late life;Left Ventricular Ejection Fraction;Measurement;Measures;Mediating;Mediator;medical schools;Medicine;Mentors;mid-career faculty;Minority;Molecular;Morbidity - disease rate;mortality;multiple omics;Myocardial dysfunction;Myocardial Infarction;next generation;novel;novel strategies;novel therapeutics;Outcome;participant enrollment;Pathway interactions;patient oriented research;Patients;Pattern;peer;Phenotype;Physiological;Positioning Attribute;preservation;pressure;Prevalence;prevent;Prevention;programs;prospective;Prospective cohort;Proteins;Proteomics;Public Health;Public Health Schools;Publications;Pulmonary Vascular Resistance;Pulmonary Wedge Pressure;randomized, clinical trials;Research;Research Personnel;resilience;Resources;Rest;Risk;Risk Factors;Science;Secure;serial imaging;skills;Technical Expertise;Therapeutic;Time;Training;training opportunity;translational genomics;translational proteomics;United States National Institutes of Health;whole genome;Woman

PROJECT_TITLE: Mentoring patient-oriented research in deep phenotyping of cardiac function for heart failure prevention

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(JA)]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Cancer

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

PHR: Narrative: The goal of this training program at the University of Minnesota Masonic Cancer Center is to train a diverse group of highly qualified individuals to become future scientific leaders working in basic and translational laboratory research and/or science-related careers to address fundamental problems in cancer biology. A strong scientific work force and the new knowledge they gain will translate to better cancer outcomes.

PI_NAMEs: LANGE, CAROL A (contact)

PROGRAM_OFFICER_NAME: LIM, SUSAN E

PROJECT_TERMS: cellular targeting;Genetic;Malignant Neoplasms;Molecular;Training Programs

PROJECT_TITLE: Molecular, Genetic and Cellular Targets of Cancer Training Program

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

ORG_CITY: EUGENE

ORG_NAME: UNIVERSITY OF OREGON

PHR: PROJECT NARRATIVE Neural circuit and brain function rely upon the complex and distinct biochemical assembly of synapses: structures where neurons transmit information either chemically or electrically. While chemical synapse proteins have been well characterized, the molecules and interactions that build electrical synapses remain largely a mystery. This proposal will investigate the biochemistry of an electrical synapse scaffolding protein to reveal a model of electrical synapse development and build a foundation to understand this critical piece of human health.

PI_NAMEs: KAYE, LILA E (contact)

PROGRAM_OFFICER_NAME: KIM, JENNY LILY

PROJECT_TERMS: Acceleration;Adult;analog;Animals;Antibodies;Architecture;Automobile Driving;Binding;Binding Proteins;Biochemical;Biochemistry;Biological;Biological Assay;Biological Models;Brain;C-terminal;Cell Culture Techniques;Cells;Chemical Synapse;Chemicals;Chemistry;Client;Communication;Complex;Connexins;Cytoplasm;Data;density;Development;Disease;DLG4 gene;Electrical Synapse;Electrons;Embryo;Epithelium;experimental study;fascinate;fluorescence imaging;Foundations;Gap Junctions;Genetic;Genetic Techniques;genomic locus;Health;Human;Image;Imaging Techniques;Impairment;in vivo;in vivo Model;innovation;Integral Membrane Protein;Investigation;Knowledge;Link;Liquid substance;loss of function;Mediating;Membrane;Metabolic;Modeling;Molecular;molecular assembly/self assembly;molecular domain;mutant;N-terminal;neural circuit;neurodevelopment;Neurons;neurotransmission;Optics;Pathway interactions;Phase;Physical condensation;postsynaptic;Postsynaptic Membrane;presynaptic;Property;Protein Binding Domain;Protein Biochemistry;Protein C;Protein Dynamics;Proteins;Publishing;recruit;Role;scaffold;Scaffolding Protein;Series;Stains;Stereotyping;Structure;Synapses;synaptic function;Synaptic Membranes;synaptogenesis;Tail;Testing;Tight Junctions;Training;Transgenic Animals;Translating;Visualization;Zebrafish

PROJECT_TITLE: Investigating the Molecular Mechanisms that Drive Electrical Synapse Development


ADMINISTERING_IC: FD

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: STORRS-MANSFIELD

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF CONNECTICUT STORRS

ORG_STATE: CT

PHR: PROJECT NARRATIVE This proposal seeks to investigate qualitatively and quantitatively inequivalent (non-Q1/Q2 equivalent) levonorgestrel (LNG) intrauterine system (IUS) formulations to understand the impact of critical pharmaceutical processing, formulation variations and physical structure of the device on the in vitro drug release characteristics. This research aims to facilitate the development of bioequivalence recommendations for generic IUS products through an in vitro only approach and hence simplify the development of such generic products. As a consequence of the proposed research, the regulatory burden will be reduced and clinical studies will be minimized without sacrificing product quality and safety while delivering cost-effective generic intrauterine system products to the public with minimal delay.

PI_NAMEs: BURGESS, DIANE JANE (contact)

PROGRAM_OFFICER_NAME: ZOU, YUAN

PROJECT_TITLE: Development of Real-Time and Accelerated Dissolution Methods for a Long-Acting Levonorgestrel Intrauterine System


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Genetics;Human Genome;Pediatric;Prevention;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: IOWA CITY

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: PROJECT NARRATIVE: Midfacial anomalies like orofacial clefts are commonly found in newborns, but our understanding for how they occur is limited. The overall objective of this proposal is to decipher the molecular underpinnings of midface development and associated disorders from the perspective of the neural crest, an embryonic stem cell population that gives rise to the facial skeleton. Findings from this research will illuminate the developmental basis of midfacial disorders, which will contribute to future strategies for their treatment and even prevention.

PI_NAMEs: NGUYEN, TIMOTHY  (contact)

PROGRAM_OFFICER_NAME: FUQUA, CHANTEL FAYSAN

PROJECT_TERMS: Address;Aftercare;Animal Model;Apoptosis;ATAC-seq;Behavior;Binding;Binding Sites;Bioinformatics;Biological Assay;Birth;bone;career;Cartilage;Cell Count;Cell Death;cell motility;Cell Physiology;Cell Survival;Cephalic;Chromatin;Cleavage Under Targets and Release Using Nuclease;Code;Confocal Microscopy;cost;Coupling;craniofacial;Craniofacial Abnormalities;craniofacial complex;craniofacial disorder;Data;Defect;Deformity;Development;Disease;DNA;Dysplasia;effective therapy;Elements;Embryo;Embryology;Embryonic Development;embryonic stem cell;Enhancers;Environment;epigenome;Etiology;Face;face bone structure;Financial Hardship;Frontonasal dysplasia;Future;Gene Deletion;Gene Expression;Gene Expression Profiling;gene function;gene regulatory network;Genes;Genome;genome-wide;Goals;Health;Human;Immunofluorescence Immunologic;Impairment;improved;Institution;interest;Jaw;Knock-out;Knowledge;Lead;Link;malformation;Mentorship;Methods;Modeling;Molecular;Morphogenesis;mouse genetics;Mus;mutant;Mutation;Neural Crest;Neural Crest Cell;neuroregulation;Newborn Infant;next generation sequencing;novel;novel strategies;Operative Surgical Procedures;Oral health;Orbital separation excessive;orofacial cleft;Pathogenesis;Pathology;Pathway interactions;Pattern;Phenocopy;Phenotype;Positioning Attribute;prevent;Prevention;Principal Investigator;Proliferating;Public Health;Reporter;Research;Research Personnel;Research Proposals;research study;Resources;Shapes;Shorthand;Signal Transduction;single-cell RNA sequencing;skeletal;Skeleton;skills;Specificity;Stains;stem cell population;Structural defect;Techniques;Testing;TFAP2A gene;TFAP2B gene;Tissues;Tooth structure;Training;transcription factor;treatment strategy;United States;Untranslated RNA;Zebrafish

PROJECT_TITLE: Deciphering neural crest-specific TFAP2 pathways in midface development and dysplasia

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Liver Cancer;Liver Disease;Orphan Drug;Rare Diseases

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

PHR: PROJECT NARRATIVE The proposed research is relevant to the public health because it aims to understand a basic mechanism of how aberrant signaling by an endocrine hormone FGF19 can drive a subset of hepatocellular carcinoma (HCC), which is the most common type of primary liver cancer with no effective treatments. We will explore if FGF21 can be utilized as an antagonist against these cancers and present a novel therapeutic strategy for HCC and other FGF19-driven cancers.

PI_NAMEs: LEE, SANGWON  (contact)

PROGRAM_OFFICER_NAME: GREENBERG, WILLIAM A

PROJECT_TERMS: Accounting;Address;Affect;Affinity;antagonist;autocrine;Binding;Binding Sites;Biochemical;Biological;biophysical analysis;Biophysics;cancer cell;Cell surface;Cells;Cessation of life;Clinical Research;Clinical Trials;db/db mouse;Dependence;Development;Directed Molecular Evolution;effective therapy;Effectiveness;Elements;Endocrine;Family;Family member;FGF19 gene;FGF21 gene;FGFR4 gene;Fibroblast Growth Factor;fibroblast growth factor 21;Fibroblast Growth Factor Receptors;Growth;Heparan Sulfate Proteoglycan;Hormones;Human;ileum;improved;In Vitro;in vivo;inhibitor;insight;kinase inhibitor;klotho protein;Liver;Malignant neoplasm of liver;Malignant Neoplasms;Measurement;member;Methods;mouse model;Mutation;novel;novel strategies;novel therapeutic intervention;novel therapeutics;Obese Mice;Oncogenic;Outcome;overexpression;paracrine;Pathogenicity;Pathway interactions;Patients;Phosphorylation;Phosphotransferases;predictive marker;prevent;Primary carcinoma of the liver cells;Primary Malignant Neoplasm of Liver;Proliferating;Property;Public Health;receptor;Receptor Protein-Tyrosine Kinases;refractory cancer;Research;Resistance;response;response biomarker;Role;Series;Signal Transduction;Signaling Molecule;Specificity;Structure;Survival Rate;Testing;Therapeutic;Therapeutic Agents;therapeutic target;Tissues;Transgenic Mice;treatment strategy;tumor;Tyrosine Kinase Inhibitor;United States;Variant;X-Ray Crystallography;Xenograft Model

PROJECT_TITLE: Therapeutic targeting of FGF19-driven cancers with FGF21 variants

STUDY_SECTION: DMP

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology Study Section[DMP]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Child Abuse and Neglect Research;Clinical Research;Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Methamphetamine;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Rural Health;Social Determinants of Health;Stimulant Use and Misuse;Substance Misuse;Violence Research;Women's Health Research

ORG_CITY: PORTLAND

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

PHR: PROJECT NARRATIVE Substance use during pregnancy is associated with negative maternal and infant health outcomes and numerous barriers impede delivery of well-coordinated and high-quality pregnancy and postpartum care for pregnant women with substance use disorder. In a recent pilot study, Project Nurture, a clinical model designed to combine maternity care, substance use disorder treatment, peer / doula support and case management in a single setting, was associated with reductions in child maltreatment, placement of children in foster care, and increases in both prenatal visits and maternal lengths-of-stay in the hospital. This proposal leverages Oregon's expansion of Project Nurture to five rural / frontier and underserved counties, offering an ideal opportunity to assess the effectiveness of this promising clinical and to identify how it is implemented in order to foster replication to other regions and states.

PI_NAMEs: COHEN, DEBORAH JILL (contact)

PROGRAM_OFFICER_NAME: FABIYI, CAMILLE

PROJECT_TERMS: Abruptio Placentae;Area;barrier to care;Birth;care providers;care systems;Caring;Case Management;Child;Child Abuse and Neglect;Child Rearing;Child Welfare;Clinic;Clinical;Collaborations;County;COVID-19;Data;Databases;design;Discipline of obstetrics;Disease;Effectiveness;effectiveness evaluation;Elements;Environment;Equity;expectation;Expenditure;experience;foster care;Fostering;frontier;Funding;Goals;Health;Health Expenditures;Health Services Accessibility;High Prevalence;Hospitals;Human;improved;improved outcome;Infant;Infant Health;infant outcome;integrated care;Investigation;Length of Stay;Link;Low Birth Weight Infant;Maternal Health;Measures;Medicaid;Medical;medically necessary care;methamphetamine use;Methamphetamine use disorder;model design;Modeling;Mothers;Neonatal;Neonatal Intensive Care;Newborn Infant;novel;opioid use;Oregon;Outcome;peer;Peer Review;Personal Satisfaction;Pilot Projects;polysubstance use;postpartum care;Pre-Eclampsia;Pregnancy;pregnant;Pregnant Women;Premature Birth;Premature Labor;Prenatal care;Prevalence;programs;Provider;Recommendation;Resources;Risk;Rural;rural area;rural setting;Services;Social Work;Stigmatization;Stressful Event;substance use;Substance Use Disorder;substance use treatment;Sudden infant death syndrome;supportive environment;Testing;Trauma;treatment program;United States;Vital Statistics;Withdrawal;Woman;women's outcomes

PROJECT_TITLE: Project Nurture Expansion Study

STUDY_SECTION: ODHS

STUDY_SECTION_NAME: Organization and Delivery of Health Services Study Section[ODHS]


NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Clinical Research;Data Science;Genetics;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety

ORG_CITY: NEW YORK

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Project Narrative During the perioperative period hemodynamic instability is the norm rather than the exception; the ability of clinicians to manage this instability has been associated with postoperative complications affecting more than 15 million Americans and costing more than $165 billion each year. There are no current risk scores that predict instability in real time, however the recent widespread adoption of electronic medical records and creation of genomic biobanks creates unique opportunities to develop scores that are both accurate and precise. We will use machine learning techniques to create risk scores for perioperative cardiorespiratory instability – specifically hypotension and arrhythmia – using combined electronic medical record, genomic and physiologic waveform data.

PI_NAMEs: HOFER, IRA  (contact)

PROGRAM_OFFICER_NAME: COADY, SEAN

PROJECT_TERMS: Acute;acute stress;Adoption;Advisory Committees;Affect;African American population;Algorithms;American;Arrhythmia;Atlases;automated algorithm;biobank;biological adaptation to stress;California;career;career development;Clinical Informatics;Collaborations;Complex;Computerized Medical Record;cost;Data;data integration;Data Security;Databases;deep neural network;design;Disease;diverse data;electronic data;Ensure;ethnic minority;Event;experience;feeding;Functional disorder;Genetic;Genetic Databases;genetic information;Genetic Risk;genomic data;Genomics;Goals;Health;Healthcare;hemodynamics;Hypotension;improved;Individual;Infrastructure;Inpatients;Joints;Latino Population;Logistic Regressions;long short term memory;Los Angeles;Machine Learning;machine learning model;Manuals;Medical Genetics;Medical History;Medicine;Mentors;Modeling;Modernization;Morphologic artifacts;multiple data sources;online course;Operative Surgical Procedures;Outcome;outcome prediction;Outpatients;Patient-Focused Outcomes;Patients;Performance;Perioperative;Perioperative complication;Pharmaceutical Preparations;Phenotype;phenotyping algorithm;Physiological;Physiology;Population Analysis;Population Heterogeneity;Postoperative Complications;prediction algorithm;predictive modeling;pressure;Prevalence;prevent;Process;Productivity;prognostic model;programs;Provider;Random Allocation;random forest;Recurrence;Research;Research Personnel;Risk;Signal Transduction;structured data;Subgroup;Techniques;Time;tool;Training;Universities;Work

PROJECT_TITLE: Use of Machine Learning on Integrated Electronic Medical Record, Genetic andWaveform Data to Predict Perioperative Cardiorespiratory Instability

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(MA)]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics;Neurosciences

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE Methylation is the newest component of the “Tubulin Code” that directs the dynamics and function of microtubules. This modification is made on microtubules by the same machinery that methylates chromatin, and its discovery has opened a new area of biology focused on identifying “dual-function” enzymes that read, write and erase methyl marks on both chromatin and the cytoskeleton. Here I propose to explore a new function for the histone methyltransferase NSD3 writing methyl marks on neuronal microtubules using a C. elegans model.

PI_NAMEs: PIETRYK, EDWARD  (contact)

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TERMS: Address;Alleles;alpha Tubulin;Animals;Architecture;Area;autism spectrum disorder;Behavioral;Binding Proteins;Biochemical;Biological Assay;Biology;Caenorhabditis elegans;catalyst;Cells;Chromatin;Code;Cytoskeleton;Data;Defect;dimer;Disease;Enzymes;Epigenetic Process;Family;Functional disorder;gain of function;Germ Lines;Histone Code;histone methylation;histone methyltransferase;Histones;Human;Hyperactivity;Image;Immunohistochemistry;In Vitro;in vivo;Individual;Knock-in;Knowledge;Label;Link;loss of function;Lysine;Malignant Neoplasms;Mass Spectrum Analysis;Methylation;Methyltransferase;Microscopy;Microtubules;Mitosis;model organism;Modeling;Modification;Morphology;mutant;Mutation;Neurodevelopmental Disorder;Neurons;Organism;Phenotype;Plus End of the Microtubule;polymerization;Polymers;Post-Translational Protein Processing;Protein Isoforms;Regulation;Research;Resolution;response;Role;Site;Structure;System;Techniques;Testing;Time;Tissues;tool;Touch sensation;Tubulin;Variant;Western Blotting;Writing

PROJECT_TITLE: Exploring the functional role of tubulin methylation and its regulation by mes-4/NSD in C. elegans

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-Q(20)L]


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Crohn's Disease;Digestive Diseases;Genetics;Human Genome;Inflammatory Bowel Disease;Microbiome;Prevention

ORG_CITY: DETROIT

ORG_NAME: WAYNE STATE UNIVERSITY

ORG_STATE: MI

PHR: PROJECT NARRATIVE Crohn’s Disease (CD), a chronic inflammatory autoimmune disease of the digestive tract, is associated with distinct changes in gut microbiome composition known as dysbiosis. The gut microbiome is known to modulate host gene expression in a microbial composition-dependent manner. The aim of this project is to characterize the interplay between host genetic variation and the gut microbiome occurring in CD which may provide insight into its pathophysiology and potential new therapeutic targets.

PI_NAMEs: NIRMALAN, SHREYA  (contact)

PROJECT_TERMS: Affect;Alleles;Allelic Imbalance;Architecture;Autoimmune Diseases;Binomial Model;Caring;Chemicals;Chronic;Cicatrix;Coculture Techniques;Communities;Complex;Computational Biology;Computing Methodologies;cost;Crohn's disease;Data;Databases;Diet;differential expression;Digestive System Disorders;disability;Disease;disorder risk;dysbiosis;Environmental Risk Factor;experience;Functional disorder;functional genomics;Gastrointestinal tract structure;Gene Expression;Gene Modified;Genes;Genetic;Genetic Risk;genetic risk factor;Genetic Transcription;genetic variant;Genetic Variation;genome wide association study;Genomic approach;Genotype;gut microbiome;host microbiome;host-microbe interactions;Human;Human Microbiome;Immune;Immune response;Immunosuppressive Agents;Individual;Inflammation;Inflammatory;Inflammatory Bowel Diseases;insight;Intestines;Maps;Metabolic;metagenomic sequencing;Methods;Microbe;microbial;microbial community;microbial composition;microbiome;microbiome composition;microbiota;microorganism;Morbidity - disease rate;new therapeutic target;Newly Diagnosed;novel;novel therapeutics;Operative Surgical Procedures;Opioid;Organoids;Outcome;pathogen;Pathogenesis;Pathologic;Patient Isolation;Patients;personalized therapeutic;Persons;Pharmaceutical Preparations;Phenotype;Physiological;Quality of life;Research;response;risk variant;Route;Shotguns;Stimulus;Taxonomy;Testing;therapeutic target;transcriptome;transcriptome sequencing;Treatment Cost;Variant

PROJECT_TITLE: The Interplay of Host Genetic Variation and the Gut Microbiome in Crohn's Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F08-A(21)L]


NIH_SPENDING_CATS: Natural Products

ORG_CITY: CHAPEL HILL

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE Natural products are an invaluable source of and inspiration for pharmaceuticals and agrochemicals. This project proposes to study the biosynthetic pathways of bioactive nonproteinogenic amino acid secondary metabolites that contain unusual vinyl N–O bonds. Understanding the synthesis of these small molecules and the biochemical mechanisms underlying their formation will enable our search for similar bioactive compounds and expand the toolbox of biocatalytic oxidative enzymes.

PI_NAMEs: TUREK-HERMAN, JOSHUA RAY (contact)

PROGRAM_OFFICER_NAME: JONES, LATAISIA CHERIE

PROJECT_TERMS: Agrochemicals;Amino Acids;Anabolism;Anti-Bacterial Agents;Antibiotics;Attenuated;Bacteria;bactericide;Binding;Biochemical;Bioinformatics;Biological Assay;Breathing;C-terminal;carboxylate;Cells;Chemicals;chemotherapy;cofactor;Dependence;Drug Compounding;Drug Industry;enol;Enzyme Inhibition;enzyme mechanism;Enzymes;Ethers;Ethylenes;Exhibits;experimental study;Family member;feeding;functional group;Gene Cluster;Genetic;Germination;Goals;Guanidines;Heme;Herbicides;Homoserine;Imino Acids;In Vitro;Industrialization;Iron;Medicine;member;Metabolism;metalloenzyme;Metals;Methods;microorganism;N hydroxylation;N-terminal;Natural Compound;Natural Products;Nucleosides;Oxygen;Oxygenases;Pathway interactions;Pharmaceutical Preparations;Pharmacologic Substance;Plant Growth Regulators;Plants;Property;Pseudomonas fluorescens;Pyridoxal Phosphate;Reaction;Recombinants;Reporting;Role;secondary metabolite;small molecule;small molecule inhibitor;Source;stable isotope;Streptozocin;Structure;Symbiosis;Synthesis Chemistry;System;unnatural amino acids;vinyl ether;Virulence

PROJECT_TITLE: Biosynthesis of Several Oxyvinylglycine Nonproteinogenic Amino Acids Bearing Unusual Alkoxyamine Bonds


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Neurosciences;Rare Diseases

ORG_CITY: SAN FRANCISCO

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Relevance: Adult brain cancer continues to be a significant challenge to clinicians, with over 20,000 cases diagnosed per year, and the mortality rate still among the highest of all cancers. Because the prognosis for individuals with the most common types of brain cancer remains poor, it is of critical importance that new therapies be developed. This proposal requests funds to support a training program that takes promising young investigators and trains them to understand brain tumor biology and therapy as an integrated whole. Investigators trained in this stimulating, translational and comprehensive manner will provide competent leadership for future research efforts aimed at improved treatments and outcomes for brain tumor patients.

PI_NAMEs: COSTELLO, JOSEPH F (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TITLE: Training Program in Translational Brain Tumor Research


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: Project narrative Pathogenic bacteria such as Vibrio cholerae utilize a variety of secretion systems to transport effector proteins and toxins to their environment, but a subset of these is retained on the cell-surface. Some of the cell-surface retained proteins have a novel domain that allows for a unique membrane attachment. Study of this apparent transferable domain could be used for technology development and will shed light on conserved mechanisms of membrane retention.

PI_NAMEs: ROBERTS, CAMERON  (contact)

PROGRAM_OFFICER_NAME: ZEITUNI, AMIR E

PROJECT_TERMS: Acinetobacter baumannii;Acute Diarrhea;adenylate;Autophagocytosis;Autophagosome;Bacteria;Biogenesis;Biological Assay;C-terminal;Cell Fractionation;cell growth;Cell surface;Cells;Charge;Cholera;Cholera Toxin;Code;Complex;Cytoplasm;Data;diarrheal disease;Disease;Distal;Elements;Environment;environmental change;Enzymes;Escherichia coli;Eukaryota;Fluorescence Microscopy;follow-up;Gene Deletion;gene product;Generations;Genes;Glycine;GPI Membrane Anchors;Gram-Negative Bacteria;Impairment;insight;Libraries;Lipoproteins;Maintenance;Membrane;Microbial Biofilms;Modeling;Modification;Molecular;Molecular Probes;N-terminal;novel;Nutrient;Organism;overexpression;pathogen;Pathogenesis;pathogenic bacteria;Pathway interactions;Peptide Hydrolases;Phosphatidylethanolamine;Phospholipids;Physiological;Play;Post-Translational Protein Processing;Poverty;Process;Prokaryotic Cells;Proteins;Proteomics;rhomboid;Role;Site;Specificity;Stress;Surface;Symptoms;System;Tail;technology development;Testing;Toxin;Transmembrane Domain;Type II Secretion System Pathway;Ubiquitin;Vibrio cholerae;Work

PROJECT_TITLE: Post-translational modification of GlyGly-Cterm Proteins


NIH_SPENDING_CATS: Behavioral and Social Science;Child Abuse and Neglect Research;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Pediatric;Prevention;Social Determinants of Health;Violence Research

ORG_CITY: HERSHEY

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: PENNSYLVANIA STATE UNIV HERSHEY MED CTR

PHR: This renewal application proposes to conduct a randomized controlled trial to examine how interactive, gamified micro-learning promotes knowledge retention and fosters behavior change with regard to child abuse and its reporting, and to establish that implementation of this intervention is feasible. After completing the online iLookOut for Child Abuse Core training, early childhood professionals will receive brief (5-10 minute) gamified learning exercises that they can complete on their smart phones or computers. These micro-learning exercises are designed to promote skill-building, provide opportunities to practice decision-making, reinforce learning and behavior change, and be easily and sustainably implemented.

PI_NAMEs: LEVI, BENJAMIN H. (contact)

PROGRAM_OFFICER_NAME: GILBERT, LEAH KAYE

PROJECT_TERMS: Adult;American;animation;Attitude;Awareness;Behavior;behavior change;booster vaccine;care providers;Caring;Cellular Phone;Cessation of life;Child;Child Abuse;Child Care;child protective service;Child Welfare;cognitive enhancement;Computers;cost;Credentialing;Data;Day Care;Decision Making;design;Development;digital;early childhood;Education;Educational Intervention;Educational process of instructing;Enrollment;Epidemic;Exercise;Family;family support;follow-up;Fostering;Grant;Habits;hands-on learning;Hour;Immunity;implementation intervention;implementation strategy;improved;Individual;Infant;Information Systems;instrument;Intake;Intervention;Investigation;Knowledge;Knowledge acquisition;Learning;learning strategy;Licensing;Maine;Maps;Measures;mobile computing;National Institute of Child Health and Human Development;Online Systems;Parents;Participant;Patient Self-Report;Pennsylvania;Pilot Projects;pilot test;Positioning Attribute;post intervention;programs;promoter;Randomized, Controlled Trials;Readiness;Recommendation;remediation;Reporting;Research;Research Design;Retrieval;Risk;Secure;skills;Social Work;State Government;Time;Toddler;Training;Vaccines;validation studies

PROJECT_TITLE: iLookOut for Child Abuse: Microlearning to Improve Knowledge Retention

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


NIH_SPENDING_CATS: Biotechnology;HIV/AIDS;Immunization;Infectious Diseases;Maternal Health;Pediatric;Pediatric - AIDS;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Vaccine Related;Women's Health Research

ORG_DEPT: PEDIATRICS

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: Project Narrative Despite considerable efforts to eliminate pediatric HIV-1 using antiretroviral treatment (ART), more than 150,000 infants continue to acquire HIV-1 infection annually. Alternative strategies, such as maternal/infant HIV-1 passive or active vaccination to achieve broadly neutralizing antibody (bnAb) activity in plasma, will be required to end the pediatric HIV-1 epidemic. We have identified maternal antibody responses that predict reduced risk of MTCT, yet determined that viral escape of maternal neutralizing antibodies against mothers' own circulating viruses is common in infant infections, including escape of plasma bnAb activity. We now seek to define the role of maternal plasma bnAb responses in MTCT and whether viral escape of bnAbs is a risk factor for vertical virus transmission. Understanding the impact of pre-existing bnAb activity on MTCT risk is important to design immunologic strategies that will synergize with ART to eliminate pediatric HIV infections.

PI_NAMEs: PERMAR, SALLIE R. (contact)

PROGRAM_OFFICER_NAME: LOMBO RODRIGUEZ, TANIA

PROJECT_TERMS: Accounting;Active Immunization;Antibodies;Antibody Repertoire;Antibody Response;Antibody Specificity;antiretroviral therapy;Autologous;B cell repertoire;Birth;Case Study;Cessation of life;clinical development;Clinical Research;Clinical Trials;cohort;design;Development;Epidemic;Epitopes;Future;Generations;genetic signature;Goals;high risk infant;HIV;HIV Infections;HIV therapy;HIV vaccine;HIV-1;Immune;Immunoglobulin G;Immunologics;Impairment;Infant;infant infection;Infection;Intervention;Lactation;Maps;Maternal antibody;maternal vaccination;Measures;Mediating;Monoclonal Antibodies;Mother-to-child HIV transmission;Mothers;Mutation;neutralizing antibody;novel;Passive Immunization;pediatric human immunodeficiency virus;pediatric human immunodeficiency virus infection;placental transfer;Plasma;Population;predicting response;Pregnancy;Pregnant Women;Premature Infant;pressure;prevent;Prevention strategy;Prophylactic treatment;Regimen;repository;Resistance;response;Risk;Risk Factors;Role;Route;Safety;Site;Specificity;synergism;Testing;Time;tool;transmission process;vaccine strategy;Vaccines;Variant;Vertical Disease Transmission;Vertical Transmission;Viral;Viral Physiology;viral transmission;Virus;virus envelope;Woman

PROJECT_TITLE: Escape of maternal plasma broadly neutralizing antibody as a mechanism of mother to child HIV transmission

STUDY_SECTION: HIVD

STUDY_SECTION_NAME: HIV Immunopathogenesis and Vaccine Development Study Section[HIVD]


ADMINISTERING_IC: VA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: Veterans Affairs

ORG_CITY: LOS ANGELES

ORG_NAME: VA GREATER LOS ANGELES HEALTHCARE SYSTEM

PHR: The rapid expansion of virtual care adds complexity to the provision of same day access to Primary Care- Mental Health Integration (PC-MHI) among newly referred patients. Given the important role of PC-MHI as an entry point to mental health care, and ongoing widespread virtual care use in VA, there is an urgent need for effective strategies to maximize same day access for patients who initiate PC-MHI services via virtual care. This study addresses a significant knowledge gap by evaluating mutable predictors of virtual PC-MHI same day access and identifying strategies for effective interdisciplinary care coordination. Improving virtual PC-MHI same day access can reduce burden for VA Patient Aligned Care Team (PACT) medical providers by facilitating rapid assessment and treatment of new mental health patients. The information gained from this pilot study will contribute to the development of interventions to improve virtual care coordination in integrated healthcare settings.

PI_NAMEs: LEUNG, LUCINDA B (contact)

PROJECT_TERMS: Accident and Emergency department;Address;Adoption;Affect;Ambulatory Care Facilities;Applications Grants;Appointment;Area;Award;care coordination;Caring;Characteristics;Clinic;Clinic Visits;Clinical;cohort;Communities;connected care;COVID-19;COVID-19 pandemic;Data;Day Care;design;Discipline;Electronic Health Record;Ethnic Origin;experience;follow-up;Funding;Future;Goals;handbook;health care settings;Health Personnel;Health Services Accessibility;Healthcare Systems;improved;innovation;Intervention;Interview;Knowledge;Learning;Linear Models;Measures;Medical;Medical Care Team;Medical center;medical specialties;Mental Health;Mental Health Services;Methodology;Methods;Modality;Modeling;Outcome;Patient-Focused Outcomes;Patients;Performance;Persons;Pilot Projects;Primary Care;primary care clinic;primary care practice;primary care provider;primary care team;Provider;Quality of Care;Race;Reporting;Research;research study;Risk;Role;Rural;rural healthcare;Sampling;Scientific Advances and Accomplishments;Services;Specific qualifier value;Structure;Suicide prevention;telehealth;Telephone;therapy development;Time;Urban Health;urgent care;Veterans;Veterans Health Administration;video chat;virtual;virtual healthcare;virtual patient;virtual visit;Visit

PROJECT_TITLE: Virtual Care Coordination in VA Primary Care-Mental Health Integration

STUDY_SECTION_NAME: HSR-4  Mental and Behavioral Health[HSR4]


ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative The overarching goal of this proposal is to understand how and why an actin mesh that fills the developing egg of Drosophila (fruit fly) contributes to polarity establishment. The oocytes of many species, including mammals, have analogous structures, suggesting structural and functional conservation. Thus we anticipate that what we learn about Drosophila egg development will be applicable to our understanding of cellular organization, fertility, development, and health in animals, ranging from Drosophila to humans.

PI_NAMEs: QUINLAN, MARGOT E (contact)

PROGRAM_OFFICER_NAME: RIGAS, MARC

PROJECT_TERMS: Acceleration;Actin-Binding Protein;Actins;Address;Animals;Auxins;Binding;Biochemical;Biological;Biological Models;Caenorhabditis elegans;Cell Polarity;Cells;Chemotaxis;Collaborations;Complex;Contracts;CRISPR/Cas technology;Cytoplasm;Cytoskeleton;Data;Defect;Development;Diffuse;Drosophila genus;egg;Embryo;Epithelium;Excision;experimental study;facsimile;Fertility;Filament;fluid flow;fly;Genes;Genetic;genetic approach;Genetic Models;Genetic Screening;Goals;Health;Human;imaging platform;In Vitro;in vitro Assay;in vivo;insight;intravital imaging;Kinesin;Knowledge;Learning;Maintenance;Mammals;Measures;Mediating;melanocyte;Membrane;Methods;Microtubules;model organism;Molecular Motors;Motility;Motion;Motor;Mus;Myosin Type V;Nutrient;Oocytes;Oogenesis;Ooplasm;Ovary;paralogous gene;pharmacologic;Physiological;premature;Process;Protein Isoforms;Proteins;Proteomics;reconstitution;RNA;RNA Splicing;Role;Set protein;Somatic Cell;Starfish;Stream;Structure;System;Testing;Time;tool;Translating;vacuolar H+-ATPase;Vesicle;vesicle transport;Visualization;Work

PROJECT_TITLE: Collaboration between actin nucleators - Spire and Cappuccino

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-C(02)M]