ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Data Science;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC

ORG_STATE: NY

PHR: Narrative The present proposal develops new statistical methods to examine neural mechanisms in the context of cognitive system constructs and cognitive reserve. The research proposed here will form the basis for developing a new line of statistical methods to identify functional neural mechanisms related to cognitive constructs and examine the role of brain and cognitive reserve in cognitive changes associated with cognitive aging and Alzheimer's disease. These inquires have substantial promise for Alzheimer's disease as well as aging; accurate identification of functional and structural neural system and their mechanisms is crucial to better understanding Alzheimer's disease and developing new treatments.

PI_NAMEs: LEE, SEONJOO  (contact)

PROGRAM_OFFICER_NAME: HSIAO, JOHN

PROJECT_TERMS: Accounting;Address;Adult;Aging;Algorithms;Alzheimer's Disease;Alzheimer’s disease biomarker;Amyloid;Biometry;Brain;Brain imaging;brain magnetic resonance imaging;Clinical;Cognition;Cognitive;cognitive ability;Cognitive aging;cognitive change;cognitive neuroscience;cognitive performance;cognitive reserve;cognitive system;cognitive task;Computer software;Cross-Sectional Studies;Data;Dementia;design;Development;dimension reduction;Disease;Early Diagnosis;Education;Elderly;experience;feature selection;follow-up;Functional disorder;Functional Magnetic Resonance Imaging;high dimensionality;Image;Image Analysis;imaging biomarker;imaging study;Impaired cognition;improved;Individual;individual patient;Joints;longitudinal analysis;Magnetic Resonance Imaging;Measures;Mediating;Mediation;Mediator;Medical Imaging;Methods;Monitor;morphometry;Multicenter Studies;multidimensional data;Multimodal Imaging;multimodal neuroimaging;multimodality;Nerve Degeneration;neural;neural network;neuroimaging;Neurology;neuromechanism;normal aging;novel;open source;Pathology;Pattern;Persons;Population;Positron-Emission Tomography;pre-clinical;Predisposition;Proxy;Regression Analysis;Research;Research Personnel;Rest;Role;Software Tools;Source Code;Statistical Data Interpretation;Statistical Methods;System;Testing;Thick;tool;Vocation

PROJECT_TITLE: Statistical method for neural mechanism mediating and moderating cognitive system in Alzheimer's disease and aging research.

STUDY_SECTION: BMRD

STUDY_SECTION_NAME: Biostatistical Methods and Research Design Study Section[BMRD]


ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Mental Health;Neurodegenerative;Neurosciences

ORG_CITY: ROCHESTER

ORG_COUNTRY: UNITED STATES

ORG_DEPT: OTHER BASIC SCIENCES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: PROJECT NARRATIVE  Alzheimer’s disease (AD), a persistent and devastating dementing disorder of old age, is a major public health burden whose impact is rising dramatically with the burgeoning aging population. This study will examine brain Event-Related Potentials (ERP) as useful functional components to measure normal aging and AD-related changes in affective (emotional) word processing. These ERPs are noninvasive, relatively inexpensive, directly related to brain activity, and may act as surrogate measures of affective changes due to AD.

PI_NAMEs: CHAPMAN, ROBERT M (contact)

PROGRAM_OFFICER_NAME: SUTTERER, MATTHEW

PROJECT_TERMS: 3-Dimensional;Address;Adult;Affect;Affective;aged;Aging;aging population;Alzheimer's Disease;Alzheimer's disease related dementia;Appearance;Area;Attention;behavior measurement;Behavioral;Behavioral Mechanisms;Brain;Clinical;Cognition;Cognition Disorders;Cognitive;cognitive ability;cognitive capacity;cognitive function;cognitive process;Data;demented;Dementia;Development;Dimensions;Disease;Elderly;Electrophysiology (science);Emotional;emotional functioning;emotional stimulus;Emotions;Event-Related Potentials;executive function;Experimental Designs;Functional disorder;Gender;gender difference;Goals;human old age (65+);Impaired cognition;Individual;Link;Location;Measures;Memory;men;Methods;mild cognitive impairment;Modeling;Multivariate Analysis;negative affect;neglect;neural;Neurobiology;neurophysiology;neuropsychiatry;Neuropsychological Tests;Neuropsychology;normal aging;Pathology;Process;Public Health;Research;Research Project Summaries;response;Sex Differences;Stimulus;temporal measurement;theories;Time;United States National Institutes of Health;Well in self;Woman;Word Processing;young adult

PROJECT_TITLE: Brain ERPs to Assess Emotional Function in Normal Aging and MCI/AD

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


ADMINISTERING_IC: HS

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: ANN ARBOR

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE At a half million patients and counting, the chronic dialysis population includes some of the costliest and sickest patients in the United States. Findings from this proposal will help identify better ways to provide care for these patients, in order to reduce spending and improve their clinical outcomes.

PI_NAMEs: HIRTH, RICHARD A;HOLLINGSWORTH, JOHN MALCOLM;SHAHINIAN, VAHAKN B (contact)

PROGRAM_OFFICER_NAME: EDEN, AIMEE

PROJECT_TITLE: Primary care involvement in End Stage Renal Disease Seamless Care Organizations (ESCOs) and the quality and costs of care for patients on chronic dialysis

STUDY_SECTION: HSVR

STUDY_SECTION_NAME: Healthcare Systems and Values Research[HSVR]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_CITY: CAMBRIDGE

ORG_NAME: HARVARD UNIVERSITY

ORG_STATE: MA

PHR: PROJECT NARRATIVE The statistical models to be completed in this project will be of use to the community of scientists working on a wide range of genomic studies of relevance to human health. The work will increase our understanding of the role of genomic change in the functioning of a class of loci known as enhancers, which are important in gene regulation. The project will increase our basic understanding of the functioning of enhancers and will provide the community with powerful models linking genomic variation with phenotypic variation in a phylogenetic context.

PI_NAMEs: EDWARDS, SCOTT V. (contact);FARLEY, EMMA KIRSTEN;LIU, JUN S;SACKTON, TIMOTHY ;TABIN, CLIFFORD J.

PROGRAM_OFFICER_NAME: GILCHRIST, DANIEL A

PROJECT_TERMS: Acceleration;Bayesian Modeling;Biological;Biological Assay;Birds;candidate identification;Chickens;Chromatin;Communities;comparative;comparative genomics;Complex;Data;Data Set;Development;Disease;DNA;Electroporation;Elements;Emu species;Enhancers;Epigenetic Process;epigenetic profiling;Evolution;Exhibits;Flying body movement;Forelimb;Gene Expression;Gene Expression Regulation;Genes;Genetic Diseases;Genetic Enhancer Element;Genetic Polymorphism;Genome;genome sequencing;genome wide association study;genome-wide;genomic signature;genomic variation;Genomics;Genotype;Health;Heterogeneity;high throughput screening;Hindlimb;Human;Human Genetics;improved;in vivo;Lead;Libraries;Limb structure;Link;loss of function;Malignant Neoplasms;Measures;Methods;model development;Modeling;Morphology;Mutation;novel;Nucleotides;Open Reading Frames;Organ;Phenotype;Phylogenetic Analysis;Phylogenetic Pattern;Phylogeny;Play;Population;Population Genetics;predictive modeling;Process;rate of change;Relaxation;Research Personnel;Role;Sampling;Scientist;Sorting;Source;Statistical Methods;Statistical Models;Study models;System;Testing;tool;trait;transcriptome sequencing;Trees;Untranslated RNA;user-friendly;Validation;Variant;whole genome;Work

PROJECT_TITLE: Statistical and high-throughput models of enhancer function and evolution

STUDY_SECTION: GVE

STUDY_SECTION_NAME: Genetic Variation and Evolution Study Section[GVE]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Genetics;Immunotherapy

ORG_CITY: BOSTON

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: CD4+ T regulatory (Treg) cells play key roles in maintaining immunologic tolerance to self and controlling inflammation. They are involved in several autoimmune diseases,and help tumors avoid immunosurveillance, coming in many flavors, which have been highlighted by single-cell transcriptomics. We aim to establish the growth and differentiation factors that support these Treg subsets, as a key to better understand this complex but essential cell population, and as possible therapeutic targets in autoimmunity or cancer.

PI_NAMEs: BENOIST, CHRISTOPHE O. (contact)

PROGRAM_OFFICER_NAME: JIANG, CHAO

PROJECT_TERMS: Ablation;Acute;Affect;antagonist;Antibodies;Arthritis;Autoimmune;Autoimmune Diseases;Autoimmunity;Back;Bar Codes;base;Biological Markers;biomarker panel;Blocking Antibodies;CD4 Positive T Lymphocytes;Cell Count;Cell Maintenance;Cell Physiology;Cell Separation;Cell surface;Cell Survival;Cells;Cellular biology;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Clustered Regularly Interspaced Short Palindromic Repeats;combinatorial;Complex;Cues;cytokine;Cytokine Receptors;Data;Development;Dissection;DNA;Equilibrium;Family;Family member;Feedback;Flow Cytometry;FOXP3 gene;Genes;Goals;Grant;Growth Factor;Heterogeneity;Homeostasis;Human;IL2 gene;IL7 gene;immune function;Immune Tolerance;Immunodysregulation polyendocrinopathy enteropathy X-linked syndrome;Immunologic Surveillance;Immunooncology;immunoregulation;Immunotherapy;In Vitro;in vivo;Inbred Strains Mice;Individual;Infiltration;Inflammation;Inflammatory;interest;Joints;Knowledge;Lesion;Locales;Location;loss of function;lymphoid organ;Lymphoid Tissue;Maintenance;Malignant Neoplasms;Mediator;member;Membrane Proteins;Mining;morphogens;Mus;novel;Organ;overexpression;Pathway interactions;Patients;Peripheral;Phenotype;Phosphorylation;Play;Population;Process;Proliferating;Proteome;receptor;Regulation;Regulatory T-Lymphocyte;Rest;Role;segregation;Signal Transduction;single-cell RNA sequencing;Sorting;stem cells;Structure;Surface;T cell differentiation;T-Lymphocyte Subsets;Testing;Therapeutic;therapeutic target;Thymus Gland;Tissues;transcription factor;transcriptome;transcriptomics;TSLP gene;tumor;Tumor Necrosis Factor Receptor;Variant;Work

PROJECT_TITLE: Treg cell diversity and homeostatic control

STUDY_SECTION: CMIA

STUDY_SECTION_NAME: Cellular and Molecular Immunology - A Study Section[CMIA]


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Genetics;Human Genome;Immunization;Infectious Diseases;Malaria;Malaria Vaccine;Orphan Drug;Pediatric;Precision Medicine;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases

ORG_CITY: STANFORD

ORG_DEPT: PATHOLOGY

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: PROJECT NARRATIVE The most advanced malaria vaccine candidate, RTS,S, only provides partial and rapidly waning efficacy against malaria in young children. The immunological mechanisms underlying this suboptimal response remain mysterious, and in this proposal we will utilize a systems biological approach to delineate the molecular networks that drive such responses.

PI_NAMEs: BEESON, JAMES ;PULENDRAN, BALI  (contact);VALIM, CLARISSA

PROGRAM_OFFICER_NAME: BREEN, JOSEPH J

PROJECT_TERMS: adaptive immune response;Address;Africa;African;Antibodies;Antibody Response;Biological Markers;biological systems;booster vaccine;Cells;Cellular Assay;Cessation of life;Child;Childhood;Clinical;cohort;Collaborations;computational pipelines;Computer Models;Coupled;cytokine;Cytometry;Data;Data Analyses;Data Set;effectiveness study;Epigenetic Process;epigenetic profiling;Falciparum Malaria;Future;global health;Goals;Government;gut microbiota;Herpes zoster disease;Human;Immune response;Immunity;immunogenicity;Immunoglobulin G;Immunologic Epidemiology;Immunologic Monitoring;Immunologics;Immunology;implementation study;Incidence;Innate Immune Response;insight;international center;Longitudinal cohort;Malaria;malaria infection;malaria transmission;Malaria Vaccines;Malawi;Measurement;Measures;metabolomics;Molecular;Molecular Profiling;multidisciplinary;multiple omics;Nature;Plasma;Plasmodium falciparum;Population;predictive signature;prevent;Research;response;seasonal influenza;Secondary Immunization;Serum;single cell ATAC-seq;single-cell RNA sequencing;System;Systems Analysis;Systems Biology;T-Lymphocyte;Time;tool;transcriptome sequencing;transcriptomics;Vaccination;vaccine candidate;Vaccine Design;vaccine efficacy;vaccine immunogenicity;vaccine-induced immunity;Vaccines;Work;World Health Organization;Yellow Fever

PROJECT_TITLE: Systems biological assessment of vaccination-induced protective immunity in African children


ADMINISTERING_IC: GM

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: CHARLESTON

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: PROJECT NARRATIVE The MUSC PREP program will increase the number of trained investigators in the field of biomedical research from underrepresented minority and disadvantaged backgrounds, which will in turn produce a scientific workforce better able to address health disparities, improve the efficacy of biomedical education, and ultimately improve population health in the United States. Furthermore, MUSC PREP strategies that are shown to improve retention and long-term career success of individuals from disadvantaged and under-represented groups in science will be expanded and disseminated to improve the training of biomedical scientists from all backgrounds.

PI_NAMEs: DELEON-PENNELL, KRISTINE Y (contact);PENROD-MARTIN, RACHEL

PROGRAM_OFFICER_NAME: AKACEM, LAMEESE DANA

PROJECT_TERMS: Address;Advisory Committees;Age;Award;Biomedical Research;biomedical scientist;Capital;career;Censuses;cognitive enhancement;college;Communication;Community of Practice;Critical Thinking;Data;Degree program;design;Development;Development Plans;disability;disabled;Disabled Persons;Disadvantaged;disadvantaged background;Disparity population;Doctor of Philosophy;Education;education research;Educational Activities;Educational process of instructing;Enrollment;Ensure;Environment;equity, diversity, and inclusion;Ethnic Origin;experience;Goals;graduate school;graduate student;Habits;Happiness;Health;health care delivery;health disparity;Human;improved;Individual;Institution;Intervention;investigator training;Laboratory Research;matriculation;Medical;member;Mentors;Neurologic;Oral;Outcome;Outcome Measure;Persons;Population;Population Growth;population health;Postbaccalaureate;Problem Solving;programs;psychologic;public trust;Publications;Race;Reporting;Research;Research Project Grants;role model;Scholars Program;Science;Scientist;Self Assessment;Sister;skill acquisition;skills;socioeconomic diversity;South Carolina;Structure;success;support network;Support System;Technology;Time;Training;Trust;unconscious bias;Underrepresented Minority;Underrepresented Populations;United States;United States National Institutes of Health;Universities

PROJECT_TITLE: MUSC Post-Baccalaureate Research Education Program

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - C[TWD-C]


ADMINISTERING_IC: ES

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: NORTHEASTERN UNIVERSITY

PHR: PROJECT NARRATIVE Reproductive health has been at the forefront of Puerto Ricans’ health concerns as rates of preterm birth and infant mortality in Puerto Rico are among the highest of all U.S. states and territories. The PROTECT SRC is exploring the link between exposure to a mixture of suspect chemicals from Superfund sites and adverse pregnancy outcomes in Puerto Rico, and is working to reduce that exposure. Improved understanding of the link between adverse pregnancy outcomes and contamination, together with developing sustainable technologies to reduce risk, will help improve health outcomes in Puerto Rico (a disadvantaged population) and beyond.

PI_NAMEs: ALSHAWABKEH, AKRAM N (contact)

PROGRAM_OFFICER_NAME: HENRY, HEATHER F

PROJECT_TERMS: adverse pregnancy outcome;Aromatic Polycyclic Hydrocarbons;Awareness;Back;Behavioral;Biological;Biological Markers;Cellular Phone;Chemical Exposure;Chemicals;cohort;Communication;Communities;community engagement;contaminant transport;contaminated drinking water;contaminated water;Data;Data Analyses;data management;Data Management Resources;data mining;Data Reporting;data repository;Data Set;data visualization;Development;Disparity population;drinking water;Engineering;Environment;Environmental Epidemiology;Environmental Pollution;Epidemiology;Event;experience;Exposure to;extreme weather;Floods;Friends;Geography;Goals;ground water;Health;Health Care Costs;health data;Human;human model;human subject;Hurricane;improved;in vitro Model;indexing;Individual;Infant Mortality;Infrastructure;innovation;Institution;Link;Live Birth;Machine Learning;Mediating;Metals;Methods;Michigan;Modeling;multidimensional data;new technology;novel;Outcome;Oxidative Stress;Oxidative Stress Pathway;Participant;Pathway interactions;Pesticides;phthalates;Placenta;placental membrane;Policies;Population;portability;Pregnant Women;Premature Birth;prenatal;Public Health Practice;Puerto Rican;Puerto Rico;recruit;remediation;Reporting;Reproductive Health;Research;Research Personnel;Research Project Grants;Research Support;Risk Reduction;Role;Sampling;social;socioeconomics;Solar Energy;sound;Source;Specimen;Statistical Methods;Structure;Sum;Superfund;superfund chemical;superfund site;System;Technology;Testing;tissue culture;Tissues;toxicant;Toxicology;Training;Universities;US State;Visualization software;volatile organic compound;Water;Water Purification;water treatment;Work

PROJECT_TITLE: Puerto Rico Testsite for Exploring Contamination Threats (PROTECT)


NIH_SPENDING_CATS: Social Determinants of Health

PHR: PROJECT NARRATIVE The Administrative Core provides a formal structure for oversight, planning, coordination, and promotion of cross-disciplinary interaction among all of the projects, cores, and participating institutions, as well as translation of research to stakeholders. The leadership and guidance provided by the Administrative Core is necessary to fulfill the ultimate goal of PROTECT: to understand the impact of environmental contamination on adverse pregnancy outcomes in Puerto Rico and beyond.

PROJECT_TERMS: Address;adverse pregnancy outcome;Advisory Committees;Biochemistry;Biology;Biometry;Collaborations;Communication;Communication Tools;Communities;community engagement;Computers;Coordination and Collaboration;data mining;Dedications;Discipline;Discipline of obstetrics;disease registry;Engineering;Ensure;environmental agent;Environmental Impact;Environmental Pollution;Epidemiology;Expenditure;experience;Geography;Goals;Government;Guidelines;Gynecology;Health;Human Resources;Industry;Information Technology;Institution;interest;investigator-initiated translational research;Leadership;Link;Machine Learning;Medicine;meetings;Monitor;National Institute of Environmental Health Sciences;Nature;Neonatology;Participant;Poison;Premature Birth;Progress Reports;Public Health;Puerto Rican;Puerto Rico;Qualifying;Report (document);Reporting;Research;Research Personnel;Research Project Grants;Research Support;Resources;Services;Signal Recognition Particle;Software Tools;Structure;success;Superfund;technology training;Technology Transfer;Toxicology;Training;Translating;Translational Research;Translations;United States Environmental Protection Agency;Universities;Work

PROJECT_TITLE: Administrative Core


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: MILWAUKEE

ORG_NAME: VERSITI WISCONSIN, INC.

ORG_STATE: WI

PHR: PROJECT NARRATIVE The complications of heart failure are major killers of the American population, and incidence is expected to rise by 46% in the next decade. This project will help our understanding of the mechanisms through which endothelial cells in the heart maintain normal heart function, and how defects in these responses contribute to heart failure. These are the first necessary steps in developing new strategies to restore endothelial function to prevent the progression of heart failure.

PI_NAMEs: CHRZANOWSKA, MAGDALENA  (contact);GOLDSPINK, PAUL H

PROGRAM_OFFICER_NAME: SHI, YANG

PROJECT_TERMS: adverse outcome;Affect;American;Attention;Automobile Driving;Biological Availability;Blood capillaries;Blood flow;Blood Vessels;Cardiac;Cardiac Myocytes;cardiogenesis;Cardiovascular Diseases;Cell Communication;Cell Physiology;Cessation of life;Coculture Techniques;Collaborations;Communication;Coronary;Coronary Vessels;Data;Defect;Development;Disease;Electrophysiology (science);Endothelial Cells;endothelial dysfunction;endothelial repair;Endothelium;Evaluation;Functional disorder;Future;Goals;Growth;Health;Heart;Heart failure;heart function;heart preservation;Homeostasis;Human;Impairment;In Vitro;in vivo;Incidence;Ion Channel;Knockout Mice;Knowledge;Maintenance;Measurement;Mediating;Metabolism;Molecular;Monomeric GTP-Binding Proteins;mortality;Mus;Muscle Cells;Nitric Oxide;novel;pandemic disease;paracrine;Paracrine Communication;patch clamp;Pathway interactions;Periodicity;Persons;Phenotype;Physiology;Population;postnatal;preservation;prevent;Production;Protein Isoforms;Regulation;release factor;repaired;Research;response;Role;shear stress;Signal Pathway;Signal Transduction;Smooth Muscle Myocytes;STIM1 gene;Testing;Therapeutic Intervention;therapy design;Tissues;transcriptomics;Vascular Permeabilities;Vasodilation

PROJECT_TITLE: Endothelial Rap1 in the control of heart function

STUDY_SECTION: BBHV

STUDY_SECTION_NAME: Basic Biology of Blood, Heart and Vasculature Study Section [BBHV]


NIH_SPENDING_CATS: Clinical Research;Contraception/Reproduction;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Women's Health Research

PHR: PROJECT NARRATIVE The Human Subjects and Sampling Core provides human subjects data, human biological specimens, and environmental samples to multiple projects in the program to facilitate needed research on environmental contamination in Puerto Rico and environmental and other contributors to adverse pregnancy outcomes. Knowledge gained through this research will inform effective public health strategies for preventing adverse pregnancy outcomes in Puerto Rico and the United States and for reducing exposures to environmental contaminants among pregnant women.

PI_NAMEs: CORDERO, JOSE F (contact)

PROJECT_TERMS: Adherence;adverse pregnancy outcome;Affect;Archives;Aromatic Polycyclic Hydrocarbons;Biological;Birth;Birth Rate;Chemicals;Clinic;cohort;Collaborations;Collection;Communities;community engagement;Data;Data Analyses;data management;data sharing;Databases;Drops;Ensure;environmental agent;Environmental Exposure;Environmental Pollutants;Environmental Pollution;experience;Exposure to;Fetal Growth Retardation;follow-up;Funding;Gestational Diabetes;graduate student;ground water;Health;Health Care Costs;Home;Hospitals;Human;human subject;Individual;Infrastructure;interest;Interview;Knowledge;Laboratories;landfill;Link;Live Birth;Low Birth Weight Infant;Medical Records;Metals;Modeling;multiple data sources;Participant;Pesticides;phthalates;Physicians;Placenta;pollutant;Postpartum Period;Pre-Eclampsia;Pregnancy;pregnant;Pregnant Women;Premature Birth;prenatal;prevent;Process;programs;Protocols documentation;Public Health;Public Health Schools;Puerto Rico;Qualifying;quality assurance;Records;recruit;remediation;repository;Research;Research Personnel;Resources;Sample Size;Sampling;Site;Source;Specimen;Standardization;Student recruitment;Study Subject;success;superfund chemical;superfund site;System;systems research;Team Nursing;Time;time use;Training;Translating;Umbilical Cord Blood;United States;Universities;Visit;volatile organic compound;Water;Women's study;Work

PROJECT_TITLE: Human Subjects and Sampling Core


ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project narrative A growing body of evidence indicates that inflammation plays a critical role in the development and progression of heart failure, a debilitating disease that affects 6 million Americans. Unfortunately, efforts to develop anti- inflammatory therapies to prevent and treat heart failure have been, so far, mostly unsuccessful. Here, we propose to elucidate the role that B cells play in the inflammatory response triggered by cardiac injury, with the vision that this knowledge might be harnessed to develop innovative therapies to treat patients who experience heart damage.

PI_NAMEs: ADAMO, LUIGI  (contact)

PROJECT_TERMS: Acute;Address;Adoptive Transfer;Affect;American;Animals;Anti-Inflammatory Agents;Antibodies;Antibody Formation;Antigen Presentation;Antigen Presentation Pathway;Antigens;B Cell Proliferation;B cell therapy;B-Cell Activation;B-Cell Antigen Receptor;B-Cell Development;B-Lymphocytes;Binding;Biology;Cardiac;CCR5 gene;CCR5 Signaling Pathway;Cell Adhesion Molecules;cell motility;Cells;Cellular biology;Chronic;Coculture Techniques;CXCL13 gene;cytokine;Data;Development;Disease;Disease Progression;Endothelial Cells;Endothelium;Environment;experience;Goals;Heart;heart damage;Heart failure;heart function;Heart Injuries;Histologic;Histology;human tissue;humoral immunity deficiency;Immune response;immunomodulatory therapies;immunoregulation;improved;In Vitro;in vivo;Inflammation;Inflammatory;Inflammatory Response;injured;Injury;innovation;Innovative Therapy;intravital microscopy;Knowledge;Macaca;Mediating;Mus;Myocardial;Myocardial dysfunction;Myocardial Infarction;myocardial injury;Myocardial Reperfusion Injury;Myocardial tissue;Myocardium;nonhuman primate;P-selectin ligand protein;Pathway interactions;Patients;peripheral blood;pharmacologic;Play;Population;prevent;Process;Proliferating;Qualifying;rational design;Reaction;recruit;Regional Perfusion;Reporter;Reporting;Research;Research Personnel;response;Rodent;Role;Scientist;Seasons;Signal Transduction;single cell sequencing;small molecule;Spleen;Splenectomy;Structure;System;systemic inflammatory response;targeted treatment;Techniques;Testing;Therapeutic Intervention;therapeutic target;timeline;Transgenic Mice;Transplantation;Vascular Endothelium;Vision;Work

PROJECT_TITLE: Myocardial-associated B lymphocytes and inflammatory injury

STUDY_SECTION: MPPA

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology A Study Section [MPPA]


NIH_SPENDING_CATS: Bioengineering;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Social Determinants of Health

PHR: PROJECT NARRATIVE The Data Management and Analysis Core (DMAC) plays a critical role in the efficient and secure transmission, storage, cleaning, harmonization, management, sharing, analysis and dissemination of biomedical and environmental data collected and analyzed across the PROTECT center. The DMAC provides software- engineered user-friendly analytic tools and automated pipelines to address the needs of the projects and other cores in PROTECT, and enables cross-project collaboration through data integration and harmonization, and effectively accommodates the growing volume and velocity of data collection. Effective study design, data management and analysis are key components to efficiently understanding the impact of environmental contamination on adverse pregnancy outcomes across the spectrum of research, training and community engagement activities in PROTECT.

PI_NAMEs: KAELI, DAVID R (contact)

PROJECT_TERMS: Address;adverse pregnancy outcome;analysis pipeline;analytical tool;Archives;Aromatic Polycyclic Hydrocarbons;Attention;Back;Biological Markers;Cluster Analysis;Collaborations;Collection;Communication;Communities;community engagement;Complex;Computer software;Data;Data Analyses;Data Analytics;data cleaning;Data Collection;data communication;data dictionary;data exchange;data harmonization;data integration;data management;data mining;Data Protection;Data Reporting;data repository;Data Set;Database Management Systems;Databases;design;diverse data;Education;Ensure;Environmental Health;Environmental Impact;Environmental Pollution;Environmental Risk Factor;Environmental Science;epidemiology study;Equipment and supply inventories;Exposure to;extreme weather;Fostering;Future;Geographic Information Systems;Goals;ground water;Guidelines;Health;human subject;indexing;Individual;Infrastructure;innovation;Institutional Review Boards;Machine Learning;Maps;Mediation;Mediator;Medical History;Metals;Methods;Modeling;Outcome;Oxidative Stress Pathway;Pesticides;phthalates;Play;pollutant;Privacy;Procedures;programs;Protocols documentation;Provider;Puerto Rico;Pythons;Records;Regression Analysis;remediation;Reporting;repository;Reproducibility of Results;Research;Research Design;Research Personnel;Role;Sampling;Secure;Security;Software Engineering;statistical and machine learning;Statistical Data Interpretation;Statistical Methods;support tools;Technology;tool;Toxicology;Training;transmission process;user-friendly;Visual;Visualization;Visualization software;volatile organic compound;webinar;Work

PROJECT_TITLE: Data Management and Analysis Core


NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: PIEPER, KELSEY JANETTE (contact)

PROJECT_TERMS: Academia;Area;Award;Biometry;career;Collaborations;Communication;Communities;community building;community engagement;Complex;cultural competence;Data Analyses;Data Analytics;data management;Data Science;design;Development;Development Plans;Discipline;doctoral student;Education;Educational Status;Elements;Engineering;Ensure;Environment;Environmental Engineering technology;Environmental Health;environmental justice;Epidemiology;Ethics;experience;Exposure to;Fellowship;Funding;Future;Geography;Geology;Government;health practice;Health Professional;human subject;improved;Individual;Industry;innovation;Institution;Leadership;Learning;Logic;Measures;Medical;meetings;member;Mentors;Mentorship;Methodology;Michigan;Modality;Modeling;multidisciplinary;Outcome;Output;Participant;Pathway interactions;Persons;Population;Positioning Attribute;Postdoctoral Fellow;posters;professional students;Program Evaluation;programs;Public Health;Publications;Puerto Rico;recruit;Research;Research Methodology;Research Personnel;Resources;Role;Sampling;Science;Secure;Signal Recognition Particle;Site;skills;Social Justice;Sociology;Students;success;Technology;Time;tool;Toxicology;Training;Training and Education;Translational Research;Underrepresented Minority;Underserved Population;Universities;webinar;West Virginia

PROJECT_TITLE: Research Experiences and Training Coordination Core


NIH_SPENDING_CATS: Behavioral and Social Science;Climate-Related Exposures and Conditions;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Social Determinants of Health

PHR: PROJECT NARRATIVE The Community Engagement core provides bidirectional and ethical communication between the research projects/support cores and community, to facilitate much-needed understanding about environmental contamination in Puerto Rico as well as other contributors to preterm birth and other adverse pregnancy outcomes. Knowledge gained through this work will inform effective public health strategies for preventing those adverse outcomes in Puerto Rico and the U.S., as well as strategies to reduce exposures to environmental contaminants among pregnant women.

PI_NAMEs: BROWN, PHILIP M. (contact)

PROJECT_TERMS: adverse outcome;adverse pregnancy outcome;Advisory Committees;Advocacy;Advocate;Affect;Area;Back;Birth Rate;Caring;Child Health;citizen science;Clinic;Clinical;Cohort Studies;Collaborations;Communication;Communities;community based participatory research;community engagement;Community Health;community organizations;community partners;contaminated drinking water;Data Aggregation;Data Analyses;data management;Development;Disasters;disparity reduction;Early Intervention;Education;Educational Materials;Educational process of instructing;emergency preparedness;Emergency response;Emergency Situation;Ensure;Environmental Exposure;Environmental Health;Environmental Pollutants;Environmental Pollution;Epidemic;Ethics;Event;experience;Exposure to;Family;Feedback;Floods;Focus Groups;Foundations;Goals;ground water;Health;Health education;Health Educators;health literacy;Health Personnel;Health Professional;Health Promotion;human subject;Hurricane;improved;Individual;Infant Mortality;innovation;interest;Knowledge;Learning;Maternal and Child Health;meetings;Methods;Mission;Neighborhood Health Center;Nursing Staff;Pamphlets;Participant;participant retention;patient engagement;Patient Recruitments;Pregnancy;Pregnant Women;Premature Birth;prevent;Prevention;Privatization;Process;Public Health;Puerto Rican;Puerto Rico;Recovery;recruit;remediation;Reporting;Reproductive Health;Research;Research Personnel;Research Project Grants;Research Proposals;Resources;Risk Reduction;Role;Safety;Sampling;service intervention;service providers;Site;smartphone application;social;Social Work;stem;STEM research;Superfund;superfund chemical;superfund site;systems research;Testing;Training;Translational Research;Trust;usability;Water;Woman;Work;ZIKA

PROJECT_TITLE: Community Engagement Core


NIH_SPENDING_CATS: Hematology;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: DALLAS

ORG_DEPT: PEDIATRICS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: PROJECT NARRATIVE We developed methods to measure metabolism in rare cell types and found that T cell progenitors depend on pyruvate dehydrogenase. We propose to dissect the cell-type specific requirements of glycolysis and glucose oxidation in hematopoietic stem cells and restricted progenitors using a combination of direct genetic and metabolomics experiments. Our proposal will resolve long-standing questions in stem and progenitor cell metabolism and could revise our understanding of how textbook biochemical principles apply to cells in vivo.

PI_NAMEs: AGATHOCLEOUS, MICHALIS  (contact)

PROGRAM_OFFICER_NAME: BAI, C BRIAN

PROJECT_TERMS: Ablation;Acetyl Coenzyme A;Address;adult stem cell;B-Lymphocytes;Biochemical;Bone Marrow;Bone Marrow Cells;Carbon;Cell Respiration;cell type;Cells;Cellular biology;Cellular Metabolic Process;Citric Acid Cycle;Dependence;Embryo;Enzymes;Equilibrium;Erythropoiesis;experimental study;Fermentation;flexibility;Frequencies;Gatekeeping;Genetic;Glucose;glucose metabolism;Glutathione;Glycolysis;Hematopoiesis;Hematopoietic;hematopoietic differentiation;Hematopoietic stem cells;Hematopoietic System;Homeostasis;Impairment;In Vitro;in vivo;Individual;innovation;Isotopes;Label;Lactate Dehydrogenase;Measures;Mediating;Metabolic;Metabolic Pathway;Metabolism;metabolome;metabolomics;Methods;mouse model;Myelogenous;Myeloid Progenitor Cells;NADH;Natural regeneration;Nature;nerve stem cell;Neurons;novel;Nutrient;nutrient metabolism;oxidation;Oxidation-Reduction;Pathway interactions;Positioning Attribute;Production;progenitor;Protein Isoforms;Pyruvate;pyruvate dehydrogenase;Role;Specificity;stable isotope;Stable Isotope Labeling;stem;stem cell function;stem cells;T-Lymphocyte;Testing;Textbooks;thymic regeneration;Thymus Gland;Tissues;Work

PROJECT_TITLE: The role of glycolysis and glucose oxidation in hematopoiesis


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Immunotherapy;Neurosciences;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative In this proposal, we will evaluate the use of olfactory ensheating cells for glioblastoma therapy. We will use different intracranial glioblastoma models, which infiltrate the brain of mice similar to human tumors in combination with standard of care (temozolomide and radiation). We will also attempt to understand the mechanism by which these cells are killing glioblastoma cells.

PI_NAMEs: BREAKEFIELD, XANDRA OWENS (contact)

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: adaptive immune response;adaptive immunity;Adult;Affect;Antibodies;arm;Autologous Transplantation;Axon;Brain;Brain Neoplasms;Cell Communication;cell killing;cell motility;Cell Proliferation;Cell secretion;Cell Therapy;cell type;Cells;Central Nervous System;Central Nervous System Neoplasms;Cessation of life;chemokine;Chemotherapy and/or radiation;Clinic;clinical translation;conventional therapy;Cues;cytokine;cytotoxic;Data;Development;Disease Progression;efficacy evaluation;Excision;exhaust;Glioblastoma;Glioma;Growth;Homing;Human;Immune;immune activation;Immune response;immunoregulation;Immunosuppression;in vivo;Infiltration;Inflammatory;Injury;Intranasal Administration;Life;Maintenance;Malignant - descriptor;Mesenchymal;Mesenchymal Stem Cells;migration;Modeling;Mus;Natural Immunity;neoplastic cell;Nerve Regeneration;nerve stem cell;neural;Neurites;Neuroglia;neurological pathology;neuroprotection;Normal Cell;olfactory bulb;Olfactory Epithelium;Olfactory Pathways;Olfactory Receptor Neurons;Operative Surgical Procedures;Pathway interactions;patient derived xenograft model;Patients;Peripheral Nervous System;Phagocytes;Physiological;Predisposition;prevent;Process;programmed cell death protein 1;Proliferating;Property;Radiation;Recurrent tumor;Resistance;Role;Route;sex as a biological variable;Shapes;standard of care;stem cell differentiation;stem cell therapy;stem cells;stem-like cell;stemness;Stream;Survival Rate;T-Lymphocyte;targeted treatment;temozolomide;Therapeutic;Therapeutic Effect;therapeutic transgene;Time;Tropism;tumor;tumor growth;Tumor Immunity

PROJECT_TITLE: Immuno-Cell Therapy for Brain Tumors

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-M(08)F]


NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Women's Health Research

PHR: PROJECT NARRATIVE The high rates of preterm birth and other adverse pregnancy outcomes in the US remain a significant public health challenge. The problem is even larger in Puerto Rico, where a large number of hazardous waste sites and subsequent environmental contamination also pose major issues. This prospective cohort study will use state-of-the-art molecular epidemiological methods to provide much needed information on environmental and other factors that contribute to adverse pregnancy outcomes in Puerto Rico to inform risk reduction strategies.

PI_NAMEs: MEEKER, JOHN D. (contact)

PROJECT_TERMS: 37 weeks gestation;adverse pregnancy outcome;Arachidonic Acids;Area;Aromatic Polycyclic Hydrocarbons;Behavioral;Biological;Biological Markers;Biostatistical Methods;Birth Rate;Birth Weight;Chemical Exposure;Chemicals;cohort;Cohort Studies;Collaborations;community engagement;Consensus;Cytochrome P450;Data;Data Analyses;data management;Eicosanoids;environmental agent;Environmental Pollution;Environmental Risk Factor;Epidemiologic Methods;Epidemiology;Event;Exposure to;Fetal Growth Retardation;Floods;Future;Geography;Gestational Diabetes;Hazardous Chemicals;Hazardous Waste Sites;Health;health assessment;high dimensionality;high risk population;human data;human subject;Hurricane;Individual;Infant Mortality;innovation;insight;interest;Intervention;Isoprostanes;Link;Lipoxygenase;Live Birth;longitudinal analysis;Mediation;Mediator;Metals;Methods;Modernization;modifiable risk;Molecular Epidemiology;novel;Outcome;Outcome Study;oxidation;Oxidative Stress;Oxidative Stress Pathway;Pathway interactions;phthalates;Policies;pollutant;Population;Pre-Eclampsia;Predisposition;Pregnancy;Pregnancy Outcome;Pregnant Women;Premature Birth;prevent;Prospective, cohort study;Prostaglandin-Endoperoxide Synthase;Public Health;Puerto Rico;recruit;Research Design;Risk Factors;Risk Reduction;Role;sample collection;Sampling;Source;Statistical Methods;Superfund;Techniques;Tyrosine;Ultrasonography;United States;Weather;Work

PROJECT_TITLE: Project 1 - Biomarker Epidemiology of Exposure to Mixtures, Oxidative Stress, and Adverse Pregnancy Outcomes in Puerto Rico


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Project Narrative The proposed research is relevant to public health because it employs a novel and innovative intervention that addresses mental health challenges and life skills to empower young people (10-24 years of age) to live a healthy and productive life despite living with HIV. An investment in developmentally tailored interventions to prevent or reduce mental health challenges in this important population will result in improved adherence to medication and viral suppression, leading to improved physical health and productivity in society. Relevant to the NIH HIV- related research priorities, this intervention addresses mental health as a comorbid condition and seeks to reduce HIV incidence through increased viral suppression that in turn reduces the risk of HIV transmission to others.

PI_NAMEs: DOW, DOROTHY E. (contact)

PROGRAM_OFFICER_NAME: KAMATH, SUSANNAH M A

PROJECT_TERMS: acceptability and feasibility;Acquired Immunodeficiency Syndrome;Address;Adherence;Adolescence;Adult;Africa;African;Age;age group;Age Years;Anti-Retroviral Agents;antiretroviral therapy;Behavioral;Caregiver support;Caregivers;Caring;Child;Chronic Disease;Clinic;Clinical Trials;Cognitive Therapy;comorbidity;Complex;Consolidated Framework for Implementation Research;coping;Coping Skills;cost;cost effectiveness;cost-effectiveness ratio;Data;design;Development;Disclosure;Disease;Disease Outcome;Dose;Effect Modifiers (Epidemiology);effective intervention;Effectiveness;effectiveness evaluation;effectiveness/implementation trial;Emotional;empowerment;Epidemic;Equation;evidence base;Evidence based intervention;experience;Failure;Feedback;follow-up;Formulation;Foundations;Goals;Hair;Health;Health Professional;high risk population;HIV;HIV Infections;HIV-infected adolescents;hybrid type 1 design;Hybrids;implementation determinants;implementation evaluation;implementation outcomes;improved;Incidence;incremental cost-effectiveness;Individual;Infection;Informal Social Control;innovation;internalized stigma;interpersonal therapy;Intervention;intervention effect;Interview;Investments;Joints;Lead;Learning;Life;Measurement;Measures;Mediating;Mediator;medication compliance;Medicine;meetings;Mental Health;Mental Health Services;Methods;model building;Modeling;Morbidity - disease rate;mortality;motivational enhancement therapy;multidisciplinary;novel;novel strategies;Outcome;Participant;Patient Self-Report;peer;Persons;Pharmaceutical Preparations;physical conditioning;pill;Pilot Projects;Policies;Population;population health;Positioning Attribute;prevent;primary outcome;Productivity;Public Health;Randomized;Regulation;Research;Research Priority;resilience;Resource-limited setting;Risk;Risk Reduction;RNA;Sampling;Severities;sex;sexual and reproductive health;Site;skills;social;social stigma;Social support;Societies;standard of care;Stigmatization;Stress;Structure;success;Symptoms;Tanzania;Testing;therapy adherence;therapy design;therapy development;Time;Training;transmission process;Trauma;treatment arm;treatment group;trend;trial design;United States National Institutes of Health;Validation;Viral;Voice;Work;young adult;Youth

PROJECT_TITLE: SYV:  A Mental Health Intervention to Improve HIV Outcomes in Tanzanian Youth

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: EAST LANSING

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: MICHIGAN STATE UNIVERSITY

PHR: Project Narrative: The understanding, utilization and uptake of Family Health History is essential to the prevention of health disparities in the African American community. Creating a culturally tailored Family Health History tool, co-developed by members of the African American community will inform, educate and empower African Americans about health issues related to their family genealogy. Applying the knowledge gained via Family Health Histories to increase preventative behaviors including screenings thus linking people to needed health services to prevent the onset of disease and illness.

PI_NAMEs: KEY, KENT DARNELL (contact)

PROGRAM_OFFICER_NAME: BARKSDALE, CRYSTAL

PROJECT_TERMS: acceptability and feasibility;Address;African American;African American population;Area;Bacteria;Behavior;Biometry;Cardiovascular Diseases;career development;Cessation of life;Collaborations;Communication;Communities;community based participatory research;community engaged research;Conceptions;Confidence Intervals;Conscious;Data;Data Analyses;design;Diabetes Mellitus;Early Diagnosis;early screening;empowerment;Ensure;ethnic health disparity;Ethnic Origin;Event;evidence base;experience;Failure;Family;Family health status;family structure;Focus Groups;Foundations;Funding;Genealogy;General Population;Genetic;Genomics;Goals;Grant;Health;health communication;Health Disparities Research;health disparity;health literacy;Health Personnel;Health Services Needs;Heart Diseases;HIV;Hypertension;improve minority health;improved;Individual;Inherited;interest;Intervention;K-Series Research Career Programs;Knowledge;Lead;lead exposure;Length;Link;Malignant Neoplasms;Measures;member;Mentors;minority communities;Mission;Modeling;Morbidity - disease rate;mortality;National Institute on Minority Health and Health Disparities;Onset of illness;Outcome;Participant;Persons;Phase;Pilot Projects;pilot trial;poor health outcome;Population;Positioning Attribute;preference;prevent;Prevention;Preventive measure;Preventive screening;Primary Care Physician;Race;racial health disparity;Randomized;randomized trial;Recording of previous events;recruit;Reduce health disparities;Research;research and development;Research Design;Research Methodology;Research Personnel;Sampling;satisfaction;screening;Solid;Strategic Planning;Stroke;Testing;therapy design;therapy development;tool;Training;Translational Research;uptake;Water;Work;Writing

PROJECT_TITLE: Family Health Histories: Creating a culturally tailored tool to reduce health disparities in the African American Community


NIH_SPENDING_CATS: Clinical Research;Contraception/Reproduction;Endocrine Disruptors;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Racial and Ethnic Minority Health Research;Women's Health Research

PHR: PROJECT NARRATIVE  Preterm birth and low birth weight are expensive, dangerous and prevalent, with particular concern for high  rates of these adverse pregnancy outcomes in Puerto Rico. By delivering insight into underlying mechanisms,  findings from this project will contribute to strategies for integrative solutions to reduce preterm birth and low  birth weight with interventions at the individual, community, clinical, and state or federal levels.

PI_NAMEs: HARRIS, SEAN M (contact)

PROJECT_TERMS: 37 weeks gestation;adverse pregnancy outcome;Anatomy;anti-microbial peptide;Antioxidants;Bacterial Infections;bacterial resistance;Biological;Birth;Birth Rate;Cell Death;Cell Line;Cells;Clinical;Communities;Cysteine;cytokine;Dangerousness;defense response;Diethylhexyl Phthalate;Environmental Pollutants;experimental study;Exposure to;fetal;Genes;Health;Hormones;Human;human tissue;Impairment;Individual;Inflammation;Inflammatory;inhibitor;Innate Immune Response;insight;Intervention;Invaded;Knowledge;Laboratory Animal Models;Low Birth Weight Infant;Measures;Mediating;Mediator;Medical;microbial;microorganism interaction;Mission;Modeling;Oxidative Stress;Oxidative Stress Induction;Pathway interactions;Perfusion;phthalates;Placenta;placental infection;placental membrane;pollutant;Predisposition;Pregnancy;Pregnant Women;Premature Birth;Premature Labor;Production;public health intervention;Puerto Rican;Puerto Rico;reconstitution;Research;Resistance;response;Risk;Role;Stimulus;Streptococcal Infections;Streptococcus Group B;success;Superfund;superfund chemical;terephthalate;Testing;Third Pregnancy Trimester;Time;tissue culture;Tissue Model;Tissues;Toxic effect;toxicant;Toxicant exposure;Toxicology;Training;transcriptome sequencing;translational potential;Trichloroethylene;trophoblast;United States;urinary;Uterus;Villous;Woman;Work

PROJECT_TITLE: Project 2 - Toxicant-Stimulated Disruption of Gestational Tissues with Implications for Adverse Pregnancy Outcomes


NIH_SPENDING_CATS: Bioengineering;Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

ORG_CITY: UNIVERSITY PARK

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

ORG_STATE: PA

PHR: PROJECT NARRATIVE The new algorithms for assembling multiple RNA-seq samples we have proposed here will improve identifying novel transcripts and annotating gene structures. Together with existing large-scale RNA-seq data in various repositories, our multiple-sample assembly methods can therefore be used to construct accurate data-driven transcriptomes, a prerequisite for downstream expression quantification and differential analysis. As RNA-seq has become routine assay to measure gene activities, such improvement will therefore widely advance biological and biomedical research.

PI_NAMEs: SHAO, MINGFU  (contact)

PROGRAM_OFFICER_NAME: ARGUELLO, ALEXANDER

PROJECT_TERMS: Address;Algorithm Design;Algorithms;Biological;Biological Assay;biological research;Biomedical Research;Biotechnology;Communities;Complement;Complication;Computing Methodologies;Consensus;Data;data structure;Dedications;design;Effectiveness;experimental study;Foundations;Genes;genomic locus;Genotype-Tissue Expression Project;Graph;improved;indexing;Individual;Introns;Learning;learning algorithm;Length;Measures;Methods;Modeling;Nature;Neurofibrillary Tangles;novel;open source;Outcome;Phase;preservation;Protein Isoforms;Protocols documentation;Quantitative Reverse Transcriptase PCR;repository;Reproducibility;Research;RNA Splicing;Sampling;Scallop;Signal Transduction;simulation;Statistical Methods;Statistical Models;Structure;Testing;The Cancer Genome Atlas;Time;Tissues;Transcript;transcriptome;transcriptome sequencing;Typology;Update;Vision;Weight

PROJECT_TITLE: Computational Methods for Assembling Multiple RNA-seq Samples

STUDY_SECTION: BDMA

STUDY_SECTION_NAME: Biodata Management and Analysis Study Section[BDMA]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Chronic Pain;Clinical Research;Interstitial Cystitis;Neurosciences;Pain Research;Urologic Diseases

ORG_DEPT: ANESTHESIOLOGY

PHR: Project Narrative: Urologic Chronic Pelvic Pain Syndrome is a highly prevalent and debilitating chronic pain condition for which current treatments are inadequate. The current proposal addresses the link between inflammation and neurobiological mechanisms to provide insight into the pathophysiology of this condition.

PI_NAMEs: HARTE, STEVEN EDWARD (contact);SCHREPF, ANDREW

PROGRAM_OFFICER_NAME: MULLINS, CHRISTOPHER V

PROJECT_TERMS: Address;Affect;American;Bioinformatics;Biological;biotypes;Bladder;Blood specimen;Caring;Cell Separation;Central Nervous System;central pain;central pain syndrome;Chronic;chronic pain;chronic painful condition;chronic pelvic pain;Classification;Clinical;Clinical Data;clinical phenotype;Clinical Trials;cohort;comorbidity;cost;Cross-Sectional Studies;Data;debilitating symptom;Disease;Evaluation;Expenditure;experience;follow-up;Frequencies;Functional disorder;Funding;Genitourinary system;Goals;health care service utilization;Immune;Immune response;Immune system;Immunologic Stimulation;improved;individualized medicine;Inflammation;Inflammatory;inflammatory marker;Inflammatory Response;insight;interdisciplinary approach;Investigation;Link;Magnetic Resonance Imaging;model building;Modeling;multidisciplinary;neurobiological mechanism;Neurobiology;neuroimaging;Neuroimmune;neuromechanism;new therapeutic target;Outcome;Pain;Pain Research;participant enrollment;Patient Outcomes Assessments;patient subsets;Patients;Pelvic Pain;Pelvis;Peripheral;Phase;Phenotype;Play;Pre-Clinical Model;Prediction of Response to Therapy;Protocols documentation;Psychophysics;Quality of life;recruit;Research;Research Personnel;response;Rest;Role;Sampling;Sensory;Severities;Site;Symptoms;Syndrome;systemic inflammatory response;Techniques;Testing;Time;United States National Institutes of Health;urinary;urologic;urologic chronic pelvic pain syndrome;Validation;Whole Blood;Work

PROJECT_TITLE: Neuroimmune Interface in Urological Chronic Pelvic Pain Syndrome

STUDY_SECTION: SPS

STUDY_SECTION_NAME: Somatosensory and Pain Systems Study Section[SPS]


NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Foodborne Illness;Prevention

PHR: PROJECT NARRATIVE This project will generate new fundamental knowledge and develop data-driven models to assess the effect of extreme weather on potential exposure to contaminant mixtures in karst regions. When linked with epidemiological and toxicology data, such as that developed from Projects 1 and 2, the outcomes from this project will help improve understanding of exposure to contamination and links to health effects, with a focus on adverse pregnancy outcomes. It will also inform strategies for reducing exposure to hazardous substances, such as those developed by Project 4, and reducing harmful effects of those exposures on human health.

PI_NAMEs: PADILLA, INGRID Y (contact)

PROJECT_TERMS: adverse pregnancy outcome;Affect;Area;Behavior;Characteristics;Chemicals;Complex;Consumption;contaminant transport;contaminated water;Data;Data Analyses;Data Analytics;data mining;data-driven model;Deposition;Development;Diffuse;drinking water;Droughts;Dryness;Engineering;Environment;Environmental Pollution;Epidemiology;Excision;Exposure to;extreme storms;extreme weather;Fracture;Fresh Water;geochemistry;Grain;ground water;Hazardous Substances;Hazardous Waste Sites;Health;Human;Hurricane;Immobilization;improved;Infrastructure;innovation;interdisciplinary approach;Island;Knowledge;Link;Metals;Methods;Modeling;Monitor;novel;Outcome;Pattern;Pattern Recognition;Pesticides;phthalates;Play;portability;Predisposition;Pregnancy Outcome;Process;Property;Puerto Rico;Rain;Records;remediation;Research;response;Risk;risk minimization;Role;Sampling;Scientist;Source;Statistical Models;Structure;Superfund;superfund site;System;Techniques;Technology;Testing;Time;Toxic effect;Toxicology;Visualization;volatile organic compound;Water;Weather;Work

PROJECT_TITLE: Project 3 - Effect of Extreme Weather on Potential Exposure of Contaminant Mixtures in Karst Water Systems


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Biotechnology;Brain Disorders;Clinical Research;Dementia;Nanotechnology;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: ATLANTA

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative The project proposes to develop a highly sensitive nanotechnology enhanced immuno-magnetic separation and capturing system for detection and quantification of Alzheimer’s disease (AD) biomarkers, i.e., amyloid-β peptides (Aβs) and microtubule tau proteins, in readily available blood samples. The developed “liquid biopsy” system should address the unmet need in robust, cost-effective and widely accessible in vitro diagnostic tools for the clinical management of rapid growing population of AD patients at the point of care.

PI_NAMEs: MAO, HUI  (contact)

PROGRAM_OFFICER_NAME: LUO, YUAN

PROJECT_TERMS: abeta deposition;Address;Adsorption;Alzheimer disease detection;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer’s disease biomarker;Amyloid beta-42;Amyloid beta-Protein;Amyloid beta-Protein Precursor;Antibodies;antibody conjugate;Archives;Attenuated;Biological Markers;biomarker discovery;Blocking Antibodies;Blood;Blood specimen;Brain;Brain imaging;Cerebrospinal Fluid;Clinical;Clinical Management;Communities;cost;cost effective;Coupled;Data;Detection;detection platform;Development;Devices;Diagnosis;diagnostic accuracy;diagnostic biomarker;diagnostic tool;Disease Progression;Early Diagnosis;early screening;Economic Burden;effective therapy;Enhancement Technology;Enzyme-Linked Immunosorbent Assay;Equipment;Goals;Healthcare;Image;Imaging Techniques;Immunomagnetic Separation;improved;In Vitro;in-vitro diagnostics;Individual;innovation;iron oxide;Ligands;liquid biopsy;Liquid substance;Magnetic Resonance Imaging;Magnetism;Measurement;Measures;Microfluidic Microchips;Microfluidics;Microspheres;Microtubules;Monitor;multiplex detection;nano;nanoparticle;nanorod;nanosized;Nanotechnology;nanotechnology platform;neuroimaging;Noise;Patient Care;Patients;peripheral blood;Plasma;point of care;Polymers;Population;Population Heterogeneity;Positron-Emission Tomography;Prognostic Marker;programs;Protein Analysis;Proteins;Proteomics;Radioactive;radiotracer;Research;Resources;Risk;Sampling;Scanning;Sensitivity and Specificity;Serum;social;Specificity;Surface;surface coating;System;targeted biomarker;tau Proteins;tau-1;Technology;Testing;Time

PROJECT_TITLE: High-sensitivity Immunomagnetic System for "Liquid Biopsy" of Alzheimer's Disease

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Lung;Rare Diseases;Tuberculosis

ORG_CITY: WORCESTER

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: PROJECT NARRATIVE This project studies a new approach to treating TB that uses common drug called metformin that is presently used to treat diabetes. It was recently discovered that metformin can improve immunity to TB and it can be safely use in people who do not have diabetes. Results from this study will show exactly how metformin fights TB and provide new information that will support clinical trials of metformin for TB and possibly find targets for new treatments building on the knowledge we will create.

PI_NAMEs: KORNFELD, HARDY  (contact);SINGHAL, AMIT

PROGRAM_OFFICER_NAME: MONGODIN, EMMANUEL FRANCK

PROJECT_TERMS: 5'-AMP-activated protein kinase;Acceleration;adenylate kinase;Adult;Aerosols;Alveolar;antifibrotic treatment;Antigens;antimicrobial;Blood;CD44 gene;CD8B1 gene;Cell Differentiation process;Cells;Circulation;Clinical;Clinical Trials;Collagen;CXCL10 gene;CXCR3 gene;Data;design;Development;Diabetes Mellitus;Disease;Down-Regulation;Drug resistance;Elements;Epigenetic Process;experimental study;fibrogenesis;Fibrosis;fighting;Frequencies;Gene Expression;Gene Expression Regulation;global health;Goals;Human;Immune;Immunity;Impairment;improved;indium-bleomycin;Individual;Infection;Infiltration;Inflammation;Injury;ITGAM gene;Knowledge;Ligands;Lung;lung injury;lung preservation;Macrophage;Maintenance;Mediating;Memory;Metformin;Modeling;monocyte;Morality;mortality;mouse model;Mus;Mycobacterium tuberculosis;Myelogenous;Natural Immunity;new therapeutic target;Non-Insulin-Dependent Diabetes Mellitus;NOTCH1 gene;novel;novel strategies;Outcome;Participant;Pathology;Pathway interactions;Patients;Peripheral Blood Mononuclear Cell;Persons;Phagocytes;Pharmaceutical Preparations;Plasma;Proteomics;Pulmonary Fibrosis;pulmonary function;Pulmonary Tuberculosis;recruit;Recurrence;Regimen;Reporting;Resolution;response;Risk;RNA;Sampling;SELL gene;Signal Transduction;small molecule;Specificity;Spleen;Sputum;Sterilization;Structure of parenchyma of lung;Survivors;T memory cell;T-Lymphocyte;Testing;Therapy trial;tissue repair;Toxic effect;Training;transcriptome sequencing;transcriptomics;Treatment Efficacy;Tuberculosis;tuberculosis immunity;tuberculosis treatment;Up-Regulation;validation studies;virtual

PROJECT_TITLE: Lung-Protective Mechanisms of Metformin in TB

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


NIH_SPENDING_CATS: Foodborne Illness;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Rural Health

PHR: PROJECT NARRATIVE This project will develop environmentally friendly, portable, self-cleaning technologies to remove mixtures of chemicals from contaminated drinking water. These technologies are most critical in areas that lack access to public water systems or in areas that are devastated by extreme events like hurricanes. Providing clean water will help minimize the health risks, such as adverse pregnancy outcomes, that are associated with exposure to mixtures of contaminants from Superfund sites.

PI_NAMEs: ALSHAWABKEH, AKRAM N (contact)

PROJECT_TERMS: Address;Adsorption;Adverse effects;adverse pregnancy outcome;Advisory Committees;aqueous;Area;Aromatic Polycyclic Hydrocarbons;Assessment tool;Benign;Carbon;carbon fiber;Caribbean region;catalyst;Cathodes;Characteristics;Chemicals;Communities;Consumption;contaminated drinking water;cost effective;Coupled;cytotoxic;Degradation Pathway;design;Distributed Systems;Electrodes;Electrolyses;Engineering;Environment;Event;Evolution;Excision;experimental study;Exposure to;Friends;Generations;geochemistry;Goals;ground water;Hazardous Substances;Health;Hour;Hurricane;Hydrogen Peroxide;Hydroxyl Radical;improved;In Situ;in vitro Bioassay;Individual;interest;Ions;Iron;Kinetics;Laboratories;Laboratory Study;Libraries;Link;Maintenance;Measures;member;Methods;Modeling;Motivation;Natural regeneration;novel;operation;Outcome;oxidation;Palladium;Pathway interactions;Performance;Pesticides;phthalates;pilot test;Porosity;portability;Process;Puerto Rico;Reactive Oxygen Species;remediation;Reporter;residence;Risk;Risk Assessment;Risk Reduction;rural area;Rural Community;Signal Recognition Particle;Solar Energy;Solvents;Source;Superfund;superfund chemical;superfund site;Surface;System;Techniques;Technology;Testing;Time;Toxic effect;Toxicogenomics;Variant;wasting;Water;Water Purification;water sampling;Water Supply;water treatment;Work;Yeasts

PROJECT_TITLE: Project 4 - Portable, self-cleaning advanced electro-oxidation systems for distributed and point-of-use water treatment


NIH_SPENDING_CATS: Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza;Rare Diseases

ORG_DEPT: NEUROLOGY

ORG_NAME: TUFTS UNIVERSITY BOSTON

PHR: Project Narrative Microorganisms, such as the causative agent of Legionnaire’s pneumonia, often cause diseases by growing in host cells within membrane-bound compartments that are called replication vacuoles. Such intracellular microorganisms use several strategies to construct these compartments, as well as make a protective shield to prevent the host immune response from attacking them. The work in this application is directed toward investigating how the microorganism coordinates its growth with protection against host anti-pathogen responses, with the goal of determining if there is a weak link that can be exploited for antimicrobial development.

PI_NAMEs: ISBERG, RALPH R. (contact)

PROGRAM_OFFICER_NAME: ERNST, NANCY L

PROJECT_TERMS: Adaptor Signaling Protein;Aerosols;Amoeba genus;antimicrobial;arm;aspirate;Autophagocytosis;Bacteria;Bacterial Proteins;Binding;Cell-Free System;Cells;Chemistry;Collaborations;Cytoplasm;Detection;Development;Disease;Docking;Electron Microscopy;Endoplasmic Reticulum;Engineering;Eukaryotic Initiation Factors;Event;experimental study;Family;Future;Goals;Growth;helicase;Immune;Immune response;Immune signaling;Immunologic Surveillance;Infection;Label;Legionella;Legionella pneumophila;Legionnaires' Disease;Life Style;Link;Locales;Macrophage;Masks;Mediating;Membrane;Messenger RNA;Microbe;microbial;microorganism;Modeling;Modification;Molecular;Morphology;mutant;Organelles;Organism;pathogen;pathogenic bacteria;Pathway interactions;Peptide Initiation Factors;Peripheral;phosphoric diester hydrolase;Play;prevent;prion-like;Process;Protein Family;Protein Synthesis Inhibition;Protein translocation;Proteins;Proteomics;Reaction;Regulation;Resistance;response;ribosome profiling;Ribosomes;Role;Rough endoplasmic reticulum;Site;Solid;Source;Speed;Structure;System;Testing;trafficking;Transcript;transcriptome sequencing;Transfection;translation factor;Translation Initiation;Translations;Tubular formation;Ubiquitin;ubiquitin isopeptidase;Ubiquitination;Vacuole;Viral;Virulence;Work;Xenopus laevis

PROJECT_TITLE: The interface between L. pneumophila manipulation of host endoplasmic reticulum and innate immune subterfuge

STUDY_SECTION: HIBP

STUDY_SECTION_NAME: Host Interactions with Bacterial Pathogens Study Section[HIBP]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Mental Health;Neurodegenerative;Neurosciences

ORG_CITY: Columbus

ORG_DEPT: PSYCHOLOGY

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: 8. Project Narrative Models for the representation of information across continuous space and decisions made on continuous scales are developed and applied to perception, memory, and numeracy tasks. The models will be used to better understand decision-making for older adults and adults with early Alzheimer's and Mild Cognitive Impairment. The aim is a comprehensive investigation of decision-making in this new empirical and theoretical domain.

PI_NAMEs: MCKOON, GAIL A;RATCLIFF, ROGER  (contact)

PROGRAM_OFFICER_NAME: STOECKEL, LUKE

PROJECT_TERMS: Adopted;Adult;Affect;Age;Aging;Alzheimer's Disease;Alzheimer's disease patient;anxious;Applications Grants;Area;Assessment tool;Attention deficit hyperactivity disorder;base;Child;Clinical;clinical application;clinical diagnosis;clinically relevant;cognitive process;cognitive task;Color;comparative;Data;Decision Making;Decision Modeling;Decision Theory;Depressed mood;Development;Diffusion;Dimensions;discrete time;Discrimination;Dyslexia;experimental study;Eye Movements;financial literacy;Fingers;Goals;Gold;health literacy;Impaired cognition;Impairment;Individual;Investigation;Knowledge;long term memory;mathematical ability;Memory;Memory Disorders;Mental Depression;mild cognitive impairment;Modality;model development;Modeling;Motion;Neurosciences;normal aging;older adult;Parkinson Disease;Participant;Patients;Perception;Performance;Population;preservation;Process;Property;psychologic;Psychology;Reaction Time;Recovery;Research;Research Personnel;response;Sampling;Schizophrenia;Short-Term Memory;simulation;skills;Sleep;Speed;Stimulus;success;Testing;Time;touchscreen;Variant;young adult

PROJECT_TITLE: Decision Making on Continuous Scales in Aging and Alzheimers Disease

STUDY_SECTION: CP

STUDY_SECTION_NAME: Cognition and Perception Study Section[CP]


NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: COLD SPRING HARBOR

ORG_NAME: COLD SPRING HARBOR LABORATORY

PHR: PROJECT NARRATIVE Biological systems are functionally and structurally formed by complex networks of interacting molecular components, many of which are encoded in the genome. Elucidating the structure and function of these networks and understanding how their dysregulation causes disease are critical steps toward improving human health. This application seeks support for the conference on Network Biology to be held every two years in March/April 2021-25 at the Cold Spring Harbor Laboratory, to bring together experimental and computational biologists and discuss emerging trends and latest results in the field.

PI_NAMEs: STEWART, DAVID J. (contact)

PROGRAM_OFFICER_NAME: SEN, SHURJO KUMAR

PROJECT_TITLE: CSHL Network Biology Conference

STUDY_SECTION: GNOM

STUDY_SECTION_NAME: Genome Research Study Section[GNOM-G]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: NEW YORK

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: COLUMBIA UNIV NEW YORK MORNINGSIDE

PHR: Project Narrative This project will examine the effects of long term direct locus coeruleus (LC) stimulation on amyloid and tau pathology, synaptic plasticity, and memory in Alzheimer’s disease (AD). AD is a common neurodegenerative disease and poses an immense burden on society. The results of the proposed project will contribute to the knowledge base and will likely lead to novel AD therapeutics that involve the LC.

PI_NAMEs: WANG, QI  (contact)

PROGRAM_OFFICER_NAME: GRAY, ERIN EMILY

PROJECT_TERMS: Abeta clearance;Ablation;Adult;Age;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease therapeutic;Alzheimer's disease therapy;Amyloid;Amyloid beta-Protein;Animals;Antiinflammatory Effect;Behavioral;Behavioral Paradigm;Brain;Brain region;Brain Stem;Cell Nucleus;Cerebral cortex;Clinical;Clinical Research;Clinical Trials;cognitive function;cognitive task;Control Groups;Data;Deep Brain Stimulation;Dementia;Deterioration;Development;Diagnosis;Disease Progression;Dose;electric field;Euthanasia;Excision;experimental study;Focused Ultrasound;Genetic;genetic manipulation;Genotype;Goals;High Pressure Liquid Chromatography;Hippocampus;hTau Mice;Human;Immune;Impaired cognition;improved;In Vitro;Inflammatory;inhibitor;insight;Knowledge;knowledge base;Lesion;locus ceruleus structure;Long-Term Effects;Measures;Mediating;Memory;Memory impairment;Methods;Microglia;Monoamine Oxidase;Moods;mouse model;Mus;neural stimulation;Neurodegenerative Disorders;Neurofibrillary Tangles;Neurons;neuropathology;Neurotoxins;noradrenaline transporter;noradrenergic;Norepinephrine;norepinephrine system;novel;novel therapeutics;offspring;Outcome;overexpression;Pathology;Patients;Performance;Phagocytes;Phagocytosis;Prefrontal Cortex;prevent;Prosencephalon;Regulation;reuptake;Role;segregation;Senile Plaques;Slice;Societies;Source;Structure;Symptoms;Synaptic plasticity;System;targeted treatment;tau Proteins;Tauopathies;Technology;Testing;Thalamic structure;Therapeutic;therapeutic target;Time;translational impact;vagus nerve stimulation;Vagus nerve structure;Viral;Viral Vector;Work

PROJECT_TITLE: The effects of long-term locus coeruleus stimulation on amyloid/tau pathology, synaptic plasticity, and memory during Alzheimer's disease progression

STUDY_SECTION: CDIN

STUDY_SECTION_NAME: Chronic Dysfunction and Integrative Neurodegeneration Study Section[CDIN]


NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Genetics;Heart Disease;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: MADISON

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

PHR: NARRATIVE The proposed studies, if successful, will provide new insights into the exquisite control of ion channel expression underlying heart rhythms. The preliminary discoveries promise new knowledge on the biosynthesis of physiological “machines” with broad impact on a range of fields in the biomedical sciences.

PI_NAMEs: ROBERTSON, GAIL A (contact)

PROJECT_TERMS: Action Potentials;Address;Adult;Affinity;Anabolism;Binding Proteins;Biogenesis;Biological Assay;Calcium;Cardiac;Cardiac Myocytes;Cells;Collection;Complex;Coupled;Data;Disease;Electrophysiology (science);Embryo;Equilibrium;Exhibits;Fluorescent in Situ Hybridization;Funding;Heart;Heart failure;heart function;heart rhythm;Homeostasis;Human;Immunofluorescence Immunologic;induced pluripotent stem cell;induced pluripotent stem cell derived cardiomyocytes;innovation;insight;Ion Channel;knock-down;Knowledge;Lead;macromolecular assembly;Macromolecular Complexes;Mass Spectrum Analysis;Mediating;Membrane Potentials;Messenger RNA;Modeling;Multiprotein Complexes;Muscle Cells;Myocardium;Nature;novel;Outcome;Pacemakers;Pathway interactions;Physiological;protein expression;Proteins;Regulation;Reverse Transcriptase Polymerase Chain Reaction;RNA;RNA Interference;RNA-Binding Proteins;Role;Sarcolemma;Science;Shapes;single molecule;Sinoatrial Node;Sodium Channel;Specific qualifier value;Specificity;stoichiometry;System;Testing;Therapeutic;therapeutic development;Tissues;Transcript;Translations;translatome;Ventricular

PROJECT_TITLE: Translational Control of Cardiac Excitability

STUDY_SECTION: MPPB

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology B Study Section[MPPB]


NIH_SPENDING_CATS: Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Digestive Diseases;Infectious Diseases;Microbiome;Nutrition;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Rare Diseases;Vector-Borne Diseases;Women's Health Research

ORG_CITY: PROVIDENCE

ORG_NAME: RHODE ISLAND HOSPITAL

ORG_STATE: RI

PHR: Project Narrative The goals of this proposal are to provide time for the candidate to provide mentorship to junior faculty conducting patient-oriented research in global health, with a focus on optimizing interventions for parasitic diseases of pregnancy and early childhood.

PI_NAMEs: FRIEDMAN, JENNIFER F (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: absorption;Address;Age;Anemia due to Chronic Disorder;Apoptosis;Area;Award;Birth;Blood;career development;Centers of Research Excellence;Child;cohort;Collaborations;Communicable Diseases;Complex;Data;Data Set;Development;Discipline;Doctor of Philosophy;Dose;early childhood;Education;Enrollment;Equation;Excision;Faculty;Fetal Growth Retardation;Frequencies;Funding;global health;Goals;Grant;Growth;gut health;Health;helminth infection;Helminths;High birth weight infant;Hookworms;Hospitals;Housing;Human;Human Microbiome;immune activation;Immunologist;Individual;Infant;infant outcome;Inflammation;Institution;Insulin;interdisciplinary approach;interest;international center;Intervention;K-Series Research Career Programs;Letters;Low Birth Weight Infant;Malnutrition;Measures;Mediating;Mentors;Mentorship;Methodology;microbial;microbial products;microbiome;Modeling;Morbidity - disease rate;Mothers;Multi-Institutional Clinical Trial;Neurocognitive;Neurocognitive Deficit;Newborn Infant;Nutritional;Nutritional status;Outcome;Parasitic Diseases;Pathway interactions;patient oriented research;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;Phase;Philippines;Physicians;Placenta;Placental microbiome;placental morphology;Policies;Praziquantel;Pregnancy;Pregnant Women;prenatal;programs;Publications;recruit;reproductive;Research;Research Personnel;Ribosomal DNA;Risk;Sampling;Schistosomiasis;Science;Scientist;Secure;Serum;Signal Transduction;Site;skill acquisition;skills;Source;Sterility;Techniques;Time;Training;Translational Research;treatment program;Uganda;United States National Institutes of Health;Universities;Work;Writing

PROJECT_TITLE: Optimizing interventions to mitigate schistosomiasis-related morbidity among pregnant women and children

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases B Research Study Section[MID-B]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Clinical Research;Contraception/Reproduction;Endometriosis;Genetics;Infertility;Women's Health Research

ORG_CITY: COLUMBIA

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

ORG_STATE: MO

PHR: Diseases of the female reproductive tract represent a significant women's health problem. However, relatively little is known about the molecular mechanisms, precise etiology, or hormone regulation of a non-receptive endometrium in infertility. The experiments proposed in this application will utilize new animal model systems and translational studies to discover and understand these critical mechanisms.

PI_NAMEs: JEONG, JAE-WOOK  (contact);LESSEY, BRUCE A

PROGRAM_OFFICER_NAME: JOHNSTON, DANIEL STEPHEN

PROJECT_TERMS: Acceleration;Age;Animal Model;Assisted Reproductive Technology;attenuation;Biological Factors;Biological Models;bioluminescence imaging;cost;COVID-19 pandemic;Data;Decidual Cell Reactions;Defect;Development;Disease;early pregnancy;early pregnancy loss;Endometrial;Endometrial Stromal Cell;endometriosis;endometriosis-related infertility;Endometrium;Epigenetic Process;epigenetic regulation;epigenomics;Etiology;eutopic endometrium;Evaluation;experimental study;Female infertility;female reproductive tract;Fertility;Fluorescence;Gene Expression Regulation;Genes;HDAC3 gene;Histone Acetylation;Histone Deacetylase;Homeostasis;hormonal signals;hormone regulation;Human;human subject;implantation;in vivo;in vivo imaging;Infertility;innovation;Knockout Mice;Lead;Lesion;Link;Luciferases;Modeling;Molecular;mouse model;Mus;National Institute of Child Health and Human Development;Ovarian Steroid Hormone;Papio;Pathogenesis;Pharmacotherapy;Preclinical Drug Development;Pregnancy;pregnancy failure;pregnant;Prevalence;Procedures;Reporter Genes;reproductive;Resistance;restoration;Role;Sampling;Signal Transduction;Sterility;steroid hormone;Strategic Planning;Testing;Time;transcriptomics;translational medicine;Translational Research;translational study;Ultrasonography;uterine receptivity;Uterus;Visualization;Woman;Women's Health

PROJECT_TITLE: Epigenetic regulation of receptive endometrium


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Data Science;Dementia;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Precision Medicine

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

PHR: Project narrative Alzheimer's Disease (AD) affects over 5 million Americans posing a significant burden to the community and health care system. Measurements of anatomy derived from Magnetic Resonance Imaging (MRI) as well as measurements abnormal amyloid and tau protein depositions derived from Positron Emission Tomography (PET) are increasingly used in AD research. In this project, we propose to develop advanced machine learning methods that can integrate information from PET and MRI toward characterizing disease heterogeneity in preclinical and symptomatic AD. This can improve our understanding of the underlying biological causes of the disease, leading to improved diagnosis and prognosis as well as therapeutic innovation by enabling patient stratification for clinical trials.

PI_NAMEs: SOTIRAS, ARISTEIDIS  (contact)

PROGRAM_OFFICER_NAME: HSIAO, JOHN

PROJECT_TERMS: Address;Affect;Age;age related changes;aging brain;Alzheimer's Disease;Alzheimer's disease pathology;American;Amyloid;Amyloid Proteins;Anatomy;Autopsy;Biological;Biological Markers;Biometry;Brain;Brain Diseases;case control;Cerebrovascular Disorders;Clinical;Clinical Trials;Cognition;Cognitive;cognitive change;cohort;community burden;Community Healthcare;comorbidity;Complex;Data;Data Collection;Dementia;Deposition;design;Diagnosis;Diagnostic;Diagnostic Procedure;Dimensions;Disease;disease heterogeneity;Disease Marker;disorder subtype;Enabling Factors;Functional disorder;Functional Magnetic Resonance Imaging;Future;Goals;Healthcare Systems;healthy aging;Heterogeneity;Hospitals;Image;Image Analysis;imaging modality;Impaired cognition;improved;in vivo;Individual;innovation;Institution;Intuition;Label;Letters;Link;Machine Learning;machine learning algorithm;machine learning framework;machine learning method;Magnetic Resonance Imaging;Measurement;Measures;Methodology;Methods;Modality;multimodal data;Multimodal Imaging;multimodal learning;multimodal neuroimaging;multimodality;National Institute on Aging;Nature;Needs Assessment;Nerve Degeneration;Neuroanatomy;Neurodegenerative Disorders;neuroimaging;neuroinformatics;Neurology;neuropathology;novel;Outcome;Participant;Pathologic;Pathologic Processes;Pathology;patient stratification;Patients;Pattern;Performance;personalized medicine;Population;Positioning Attribute;Positron-Emission Tomography;pre-clinical;Process;Prognosis;quantitative imaging;Regression Analysis;Research;Risk Factors;Sampling;Severities;Subgroup;supervised learning;System;tau Proteins;Techniques;Testing;Therapeutic;Therapeutic Intervention;therapeutically effective;tool;Training;Uncertainty;unsupervised learning;Work

PROJECT_TITLE: Advanced machine learning algorithms that integrate multi-modal neuroimaging to quantify the heterogeneity in Alzheimer's Disease

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Data Science;Dementia;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Prevention

ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Alzheimer’s disease (AD) is now a major public health concern with life expectancy at an all-time high. In US alone, the number of affected patients is expected to triple to 13.8 million by the year 2050. This proposal focuses on the development of an ultra-high resolution multicontrast MRI protocol, with the objective of improving the accuracy of brain atrophy rates in early AD subjects. The successful completion of this proposal will yield a biomarker that is sensitive to early brain changes in AD, which can facilitate early detection in high risk population, measure progression, and quantify the efficacy of brain sparing drugs.

PI_NAMEs: JACOB, MATHEWS  (contact)

PROJECT_TERMS: 3-Dimensional;Acceleration;Affect;Age;Algorithms;Alzheimer's Disease;Anatomy;Area;Atrophic;Biological Assay;Biological Markers;Brain;brain magnetic resonance imaging;Brain Mapping;Brain region;brain shape;Cadaver;cerebral atrophy;Clinical;Clinical Protocols;cognitive testing;Compensation;convolutional neural network;Data;data analysis pipeline;Data Set;deep learning algorithm;deep learning model;Dependence;Development;direct application;Disease;Disease Progression;Early Diagnosis;Elderly;entorhinal cortex;Evolution;follow-up;Goals;Graph;high risk;high risk population;Hippocampus;Human;Image;imaging biomarker;improved;in vivo;innovation;Joint repair;Joints;Learning;Life Expectancy;Machine Learning;Magnetic Resonance Imaging;Manuals;Maps;Measures;meter;Methods;mild cognitive impairment;Modeling;Morphologic artifacts;Motion;Mutation;Nervous System Disorder;Neurodegenerative Disorders;neuropathology;novel;Patients;Performance;Pharmaceutical Preparations;Phase;Positron-Emission Tomography;pre-clinical;Protocols documentation;Public Health;Radial;Radiation exposure;reconstruction;Recovery;Reproducibility;Resolution;respiratory;Sampling;Scanning;Scheme;screening;Screening procedure;segmentation algorithm;sex;Shapes;Thick;Time;training data;Translating;Treatment Efficacy;treatment response;ultra high resolution;Validation;Variant

PROJECT_TITLE: Model Based Deep Learning Framework for Ultra-High Resolution Multi-Contrast MRI


NIH_SPENDING_CATS: Behavioral and Social Science;Breastfeeding, Lactation and Breast Milk;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infant Mortality;Networking and Information Technology R&D (NITRD);Nutrition;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Physical Injury - Accidents and Adverse Effects;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases;Sleep Research;Social Determinants of Health;Sudden Infant Death Syndrome;Telehealth;Women's Health Research

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: PROJECT NARRATIVE  Substantial racial disparities persist in sleep-related infant deaths, which comprise a large proportion of postneonatal deaths; many of the risk factors for these deaths can be modified by changes in parental practice, particularly with regards to sleep and feeding. The overall purpose of the proposed study is to test, through a 4- armed pragmatic randomized controlled trial, an intervention strategy, grounded in health behavior theory, which uses online social networks to disseminate evidence-based information in an attempt to change social norms regarding infant sleep and breastfeeding. We anticipate that impacting the social network and norms will lead to improvements in safe sleep and breastfeeding practices, which in turn may lead to a significant reduction in the incidence of sleep-related deaths, particularly in Black infants.

PI_NAMEs: COLSON, EVE R;MOON, RACHEL Y (contact);PARKER, MARGARET GRAHAM KEMPER

PROGRAM_OFFICER_NAME: MUJURU, PRISCAH

PROJECT_TERMS: Accidental Injury;Accidents;Address;Adherence;arm;Asphyxia;Attention;Attitude;Back;Back to Sleep;Beds;Behavior;behavior influence;Behavioral;Black Populations;Black race;black women;black/white disparity;Breast Feeding;Cessation of life;Child;Contingent Negative Variation;Data;Decision Making;Disparity;District of Columbia;Education;Educational Intervention;effectiveness evaluation;Electronic Mail;Environment;evidence base;experience;Facebook;Facebook delivery;Family;feeding;Friends;Health;Health behavior;Healthcare;high risk;high risk population;improved;Incidence;Infant;Infant Care;Infant Mortality;infant sleep position;injury-related death;Intervention;intervention effect;Knowledge;Learning;low socioeconomic status;Maps;Mediating;Medical;member;metropolitan;mHealth;mhealth interventions;Mothers;nutrition;Obesity;Pathway Analysis;peer;postnatal;postneonatal mortality;Pregnancy;prenatal;Privatization;programs;Provider;Race;racial disparity;Randomized, Controlled Trials;Recommendation;recruit;Risk Factors;Self Efficacy;Shapes;Sleep;sleep position;Social Change;social influence;Social Network;social networking website;social norm;Source;Special Supplemental Nutrition Program for Women, Infants, and Children;Sudden infant death syndrome;supine sleep;Testing;Text;theories;Time;tool;Trust;vaccine acceptance;video delivery;Woman

PROJECT_TITLE: Support via Online Social Networks to Promote safe Infant Care Practices Toward Reducing Racial Disparities in Infant Mortality (SUPERSONIC)

STUDY_SECTION: HDEP

STUDY_SECTION_NAME: Health Disparities and Equity Promotion Study Section[HDEP]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: East Greenwich

ORG_NAME: GORDON RESEARCH CONFERENCES

PHR: Project Narrative Comprehensive understanding of how photoreceptor systems coordinate complex biological processes from mammalian vision through bacterial pathogenicity requires a diverse set of methodologies and disciplines. Cultivating knowledge across these areas through rapid dissemination of emerging information and rigorous discussion of new findings promises important advances on many biomedical fronts that include the development of new strategies to restore vision, the better treatment of behavioral disorders and the creation of new tools to decipher and control cell biology. Thereby, the scientific discussions, research presentations and informal interactions among the diverse audiences of this established GRC/GRS will advance our understanding of naturally occurring photoreceptor systems, including those of vertebrate vision, and enable the engineering of novel photosystems for clinical and biotechnological applications.

PI_NAMEs: CRANE, BRIAN R (contact)

PROGRAM_OFFICER_NAME: ARAJ, HOUMAM H

PROJECT_TERMS: Address;Affect;American;Architecture;Area;Basic Science;Behavior;Behavior Disorders;Behavior Therapy;Behavioral;behavioral response;Biological;Biological Process;biophysical tools;Biotechnology;Blindness;cell behavior;Cell Physiology;Cells;Cellular biology;cellular imaging;Chemicals;Circadian Dysregulation;Circadian Rhythms;Clinical;Collaborations;Communities;Complex;Cryoelectron Microscopy;Defect;Development;Discipline;Disease;Ecosystem;Engineering;Equilibrium;Event;Evolution;experience;Eye;Faculty;Fostering;Foundations;frontier;Future;Genetic;Goals;graduate student;high throughput screening;Human;In Vitro;interest;Intervention;Investments;Knowledge;Light;Link;Macromolecular Complexes;Macular degeneration;magnetic field;Mediating;meetings;Mentors;Mentorship;Metagenomics;Methodology;Methods;microbial;Microfluidics;Microscopy;Mission;Modernization;Molecular;molecular imaging;Mood Disorders;Moods;Nature;new technology;next generation;Night Blindness;novel;novel strategies;Opsin;optogenetics;Organism;Participant;particle;Pathogenicity;Pathway interactions;Perception;Persons;Phenotype;Photobiology;photonics;Photoreceptors;photosystem;Phototransduction;Physiology;Postdoctoral Fellow;posters;practical application;prevent;Process;professional atmosphere;programs;protein function;receptor;reconstitution;Regulation;Research;Research Methodology;Research Personnel;response;Retinal Degeneration;Retinal Diseases;Retinitis Pigmentosa;Rhodopsin;Roentgen Rays;Role;Scientific Advances and Accomplishments;Scientist;screening;Sensory;sight restoration;Signal Pathway;Signal Transduction;Signaling Protein;single molecule;Source;Specialist;Spectrum Analysis;stem;Structural Biologist;Structure;Student Selections;Students;supportive environment;symposium;System;Systems Biology;Talents;Techniques;tomography;tool;tool development;Training;Vision;Visual System;Well in self;Work

PROJECT_TITLE: 2022 Photosensory Receptors and Signal Transduction GRC/GRS


ORG_CITY: BOSTON

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

PHR: The proposed research is relevant to public health because it will bring forth into neuroscience a powerful toolset that enables the mapping of neural activity throughout brain circuits, with spatial and temporal performance equal to the neural codes of the brain. This technology will thus enable the pinpointing of disease mechanisms, as well as new clinical targets, in a systematic and precise fashion.

PI_NAMEs: HAN, XUE  (contact)

PROGRAM_OFFICER_NAME: ALVAREZ, RUBEN PAUL

PROJECT_TERMS: 3-Dimensional;Address;anatomical tracing;Assessment tool;Axon;Behavioral;Brain;calcium indicator;Cell Fraction;Cell membrane;Cells;Clinical;Code;Communities;Corpus striatum structure;Cultured Cells;Dendrites;design;Development;Dimensions;Disease;Educational process of instructing;Engineering;Exhibits;experience;Fluorescence;Future;Grant;Hippocampus;Image;image guided;imaging modality;imaging system;In Situ;in vivo;in vivo imaging;Individual;interest;Investigation;Kinetics;Label;Libraries;Light;Location;Maps;member;Membrane;Microscopy;millisecond;Molecular;Mus;mutant;Mutation;Nature;neural;neural circuit;neural network;Neurons;Neuropil;neuroregulation;Neurosciences;neurotransmission;Noise;optogenetics;Performance;Philosophy;Population;Population Analysis;preservation;Process;Property;Public Health;Reading;Reagent;Reporter;Research;Resolution;response;Safety;Sampling;scale up;Sea;sensor;side effect;Signal Transduction;Slice;spatiotemporal;Specific qualifier value;Speed;submicron;superresolution imaging;System;Technology;Testing;Time;Tissues;tool;trafficking;ultra high resolution;Validation;Variant;Viral;voltage;Work

PROJECT_TITLE: Multidimensional Optimization of Voltage Indicators for In Vivo Neural Activity Imaging

STUDY_SECTION: CMT

STUDY_SECTION_NAME: Cellular and Molecular Technologies Study Section[CMT]


NIH_SPENDING_CATS: Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Infectious Diseases;Rare Diseases

ORG_CITY: FRESNO

ORG_DEPT: BIOLOGY

ORG_NAME: CALIFORNIA STATE UNIVERSITY FRESNO

PHR: Infectious and neurological diseases, and cancers have had a major health impact on millions of Americans. Interestingly, unique cell-to-cell bridges, known as tunneling nanotubes (TNTs), have been implicated in all three disease categories, drastically highlighting their potential health relevance and the need for a better characterization and understanding of their structure and function. In this SCORE SC1 grant, we propose to use an approach developed in our lab to identify key structural and functional components of TNTs to start building a framework to control these elusive structures.

PI_NAMEs: GOUSSET, KARINE  (contact)

PROGRAM_OFFICER_NAME: BERNAL, FEDERICO

PROJECT_TERMS: Algorithms;alpha synuclein;Alzheimer's Disease;American;Amyloid beta-Protein;Amyotrophic Lateral Sclerosis;Antigens;Award;Binding;Biological Assay;Biological Markers;Biological Models;biomarker identification;Categories;CD4 Positive T Lymphocytes;Cell Culture System;Cell Line;Cell membrane;cell type;Cells;Chemoresistance;Communicable Diseases;Complex;Cytoplasm;Detection;detection limit;Discrimination;Disease;Disparity;Endocytic Vesicle;Event;Filopodia;Flow Cytometry;Fluorescence Microscopy;Future;Genetic Materials;Genomics;Goals;Grant;Health;Herpesvirus 1;HIV-1;Human T-lymphotropic virus 1;Huntington Disease;Hypoxia;Immune Evasion;Immunologic Surveillance;In Vitro;in vivo;Individual;Infection;Influenza;Injury;Ischemia;laser capture microdissection;leukemia;Light;Malignant Breast Neoplasm;Malignant neoplasm of ovary;Malignant neoplasm of pancreas;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Mass Spectrum Analysis;Mediating;Mediator;Membrane;Membrane Fusion;Messenger RNA;Metabolic;Methods;misfolded protein;Molecular;Morphology;Multiple Myeloma;multiple omics;Nanotubes;Neoplasm Metastasis;neoplastic cell;Nervous System Disorder;Neurodegenerative Disorders;Neurons;novel;novel strategies;Organelles;Parkinson Disease;particle;pathogen;Pathogenicity;Pathway interactions;Physiological;Pilot Projects;Play;Prions;Process;Proliferating;protein aggregation;protein complex;Proteins;Proteome;Proteomics;Protocols documentation;Recovery;release of sequestered calcium ion into cytoplasm;Reproducibility;Research;Retroviridae;Role;sample fixation;Signal Pathway;Signal Transduction;Signaling Protein;Speed;Squamous cell carcinoma;Stimulus;Structure;Subcellular structure;tau Proteins;Technology;Testing;Time;Tissues;trafficking;transcriptome;tumor progression;United States National Institutes of Health;Virus

PROJECT_TITLE: Deciphering the molecular mechanisms of TNT formation and function using a multi-omic approach


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Clinical Research;Infectious Diseases

ORG_CITY: GALVESTON

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

PHR: PROJECT NARRATIVE This program will provide short-term, hands-on training for medical students in the area of infectious diseases and inflammatory disorders. It is designed to foster the interests of outstanding medical students in biomedical research and has successful outcomes in the past ten years of funding period.

PI_NAMEs: WANG, TIAN  (contact)

PROJECT_TERMS: Area;Award;Basic Science;Behavior;Biological;Biomedical Research;Blood;Brain;career;career development;Clinical;Clinical Research;Communicable Diseases;Coupling;design;Development;Disease;drug development;experience;Exposure to;Faculty;faculty mentor;Fostering;Funding;Future;Goals;Infection;Inflammation;Inflammatory;Inflammatory Response;innovation;Institution;interest;Knowledge;Leadership;Leukocytes;Liver;Manuscripts;Medical Education;Medical Research;Medical Students;Medical Technology;meetings;member;migration;Modernization;Monitor;Mucous Membrane;neuroinflammation;Oral;Organ;pathogen;Pathogenesis;Peer Review;posters;programs;Publications;Regulation;Research;Research Project Grants;Research Training;Series;Site;skills;Skin;Students;success;summer research;System;Talents;Tissues;tool;Training;training opportunity;Training Programs;transmission process;United States National Institutes of Health;Vaccines;Writing

PROJECT_TITLE: Infectious Diseases and Inflammatory Disorders Training Program

STUDY_SECTION: AITC

STUDY_SECTION_NAME: Allergy, Immunology, and Transplantation Research Committee[AITC]