NIH_SPENDING_CATS: Bioengineering;Digestive Diseases;Drug Abuse (NIDA only);Hepatitis;Hepatitis - C;Infectious Diseases;Liver Disease;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: WINSTON-SALEM

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE The opioid syndemic is a public health crisis that consists of the overlapping epidemics of opioid misuse, fatal and non-fatal overdose, human immunodeﬁciency virus and hepatitis C. Accurate and local surveillance of community levels of opioid misuse is critical to inform public health policies but is extremely challenging. This project devel- ops new surveillance science methodology for opioid misuse that is built on imperfect surveillance data already collected by the existing public health infrastructure.

PI_NAMEs: HEPLER, STACI ;KLINE, DAVID M (contact)

PROGRAM_OFFICER_NAME: DEPADILLA, LARA MIREILLE

PROJECT_TERMS: Achievement;Address;Admission activity;Area;Biological Models;Characteristics;Collaborations;Communicable Diseases;Communities;County;Data;Data Sources;Development;Elements;Emergency medical service;Epidemic;epidemic potential;Epidemiology;Equation;experience;Goals;Health;Health Policy;Hepatitis C;HIV;HIV Infections;HIV/HCV;Human;improved;Individual;Infection;Infrastructure;Link;Measurement;Measures;meetings;Methodology;Methods;model development;Modeling;multiple data sources;novel;Ohio;Opioid;opioid epidemic;opioid misuse;Outcome;Overdose;overdose death;Policy Maker;Population;Population Surveillance;Prevalence;Property;Public Health;Resources;Risk;Science;Services;social;Source;spatiotemporal;Statistical Methods;Statistical Models;Structure;surveillance data;Surveillance Methods;Surveillance Modeling;syndemic;System;Time;United States;United States Dept. of Health and Human Services;Work

PROJECT_TITLE: Spatio-temporal Methods for Surveillance of the Opioid Syndemic

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


ADMINISTERING_IC: DA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: GAINESVILLE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Project Narrative Latinx men who have sex with men (LMSM) account for the majority of new HIV infections in South Florida and are one of the only populations in the US where HIV incidence is increasing. Expanded efforts are needed to optimize the benefits of PrEP in stimulant-using LMSM, especially approaches that address the role of key cultural factors (e.g., acculturation) and social networks in relation to stimulant use/HIV risk. The proposed formative clinical research aims to develop and pilot test a culturally tailored intervention targeting the intersection of substance use and HIV in Latinx men who have sex with men (LMSM).

PI_NAMEs: COLON-BURGOS, JOSE FELIX (contact)

PROGRAM_OFFICER_NAME: LAO, GUIFANG

PROJECT_TERMS: Acculturation;Address;Affect;Appointment;Area;attentional control;Behavior Therapy;career;career development;Clinical;Clinical Research;Cocaine;Communities;Competence;condomless anal sex;contingency management;Continuity of Patient Care;County;culturally appropriate intervention;Data;design;Enrollment;Epidemic;Ethnic Population;Ethnography;evidence base;Evidence based intervention;feasibility testing;Florida;Fortification;Funding;Goals;Grant;Health;Health behavior change;health inequalities;Health Personnel;HIV;HIV Infections;HIV risk;HIV Seronegativity;HIV Seropositivity;Human immunodeficiency virus test;Immigrant;improved;Incentives;Incidence;Individual;Industry;Intervention;intervention participants;Interview;Knowledge acquisition;Latino;Latinx;Latinx population;Link;Mediator;men who have sex with men;Mentors;Mentorship;Methamphetamine;methamphetamine use;Methods;metropolitan;novel;Participant;Pathway Analysis;peer;Phase;pilot test;Population;Population Intervention;Postdoctoral Fellow;pre-exposure prophylaxis;preventive intervention;primary outcome;Public Health;Randomized, Controlled Trials;recruit;Research;Research Personnel;Research Project Grants;Rewards;Role;Scientist;Secure;Services;sexual minority group;Sexually Transmitted Diseases;skills;Social Network;stem;stimulant use;substance use;Substance Use Disorder;syndemic;tenure track;Testing;Training;trial comparing;Underserved Population;United States National Institutes of Health;uptake;Viral Load result

PROJECT_TITLE: Testing a culturally tailored behavioral intervention to reduce co-occurring substance use and HIV risk among stimulant-using Latinx Man who have sex with Man in South Florida.


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Precision Medicine

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE We propose developing Informatics for Integrating Biology and the Bedside (i2b2), a well-established, open source, platform that is currently used at over 200 hospitals and medical centers to use machine learning for identifying patient groups receiving suboptimal care. The proposed work will enable healthcare institutions across the United States to proactively reach-out to these patients, for delivering the appropriate clinical intervention. This pioneering research directly impacts public health by improving the quality of care.

PI_NAMEs: WAGHOLIKAR, KAVISHWAR B. (contact)

PROGRAM_OFFICER_NAME: REDMOND, NICOLE

PROJECT_TERMS: Area;Artificial Intelligence;base;Biology;Cardiology;Caring;Clinical;clinical care;Clinical Data;Clinical Management;clinically relevant;Code;cohort;Complex;complex modeling;Computer software;cost effectiveness;Cues;Data;data framework;data infrastructure;Development;Diabetes Mellitus;Effectiveness;Electronic Health Record;electronic health record system;Eligibility Determination;Evidence based intervention;Goals;Grouping;Guidelines;health care delivery;health information technology;Healthcare;Healthcare Systems;Hospitals;implementation facilitation;improved;Individual;Informatics;Infrastructure;insight;Institution;Intervention;Laboratories;Lipids;Machine Learning;machine learning algorithm;machine learning method;machine learning model;Malignant Neoplasms;Manuals;Medical;Medical center;Methodology;Methods;Modality;Modeling;open source;Outcome;patient population;patient registry;patient stratification;Patients;Phenotype;phrases;Population;Population Programs;precision medicine;Procedures;programs;Public Health;Quality of Care;repository;Research;Resolution;software development;Structure;structured data;System;Testing;Therapeutic;Time;tool;two-dimensional;United States;Woman;Work

PROJECT_TITLE: A framework to stratify patient cohorts for clinical management

STUDY_SECTION: BCHI

STUDY_SECTION_NAME: Biomedical Computing and Health Informatics Study Section[BCHI]


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Aging;Brain Disorders;Comparative Effectiveness Research;Contraception/Reproduction;Epilepsy;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Social Determinants of Health;Women's Health Research

ORG_CITY: CHICAGO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: Clinical trial populations are a subset of the overall population and may be biased through several factors. To better understand disease, reduce healthcare disparities for underrepresented groups, assess drug approvals, and ensure safety as the indications for a drug expand it is critical to quantify how representative clinical trials are of the real-world population. Identifying enriched and underrepresented groups offers the opportunity to identify subpopulations who may have heterogeneous treatment effects and/or underlying physiologies.

PI_NAMEs: BEAULIEU-JONES, BRETT K (contact)

PROGRAM_OFFICER_NAME: BENSON, RICHARD T

PROJECT_TERMS: Affect;Age;Age of Onset;Area;arm;Automobile Driving;Award;Biological;birth control;Caring;Clinical;Clinical Data;Clinical Trials;Complex;Computerized Medical Record;cost;Data;Data Set;Data Sources;Development;Dimensions;Disease;disease diagnosis;disorder subtype;disparity reduction;Drug Approval;Effectiveness;effectiveness analysis;efficacy clinical trial;Eligibility Determination;Ensure;Epilepsy;Equity;Estrogens;Ethnic Origin;Exclusion;Exhibits;Foundations;Future;Gait;Genes;Genetic;Geography;glucosylceramidase;Goals;Guidelines;health care disparity;Healthcare promotion;Heterogeneity;Hormonal;Hospitals;improved;inclusion criteria;Individual;Informatics;Insurance;interest;Intervention;Machine Learning;Measures;member;Menarche;Menopause;Mentors;Methodology;Methods;Modernization;multiple data sources;Mutation;Neurologic;Neurology;non-genetic;oncology trial;Parkinson Disease;Participant;patient population;Patients;Performance;Perimenopause;Perinatal;Pharmaceutical Preparations;Physiology;Placebos;Policies;Polypharmacy;Population;Positioning Attribute;Pregnancy;Price;Procedures;Randomized;Randomized, Controlled Trials;Rare Diseases;reproductive;Research;Research Personnel;Safety;Science;Seizures;sex;socioeconomic diversity;Socioeconomic Status;standard measure;standard of care;statistics;Subgroup;success;Symptoms;Target Populations;Testing;therapeutic development;Therapeutic Effect;Training;treatment effect;Treatment Efficacy;Tremor;trial comparing;Underrepresented Populations;unethical;Validation;Woman

PROJECT_TITLE: Characterizing Population Differences between Clinical Trial and Real World Populations

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-2 Study Section [NST-2]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Genetics;Patient Safety;Precision Medicine

ORG_CITY: MEMPHIS

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

ORG_STATE: TN

PHR: Project narrative Synthetic analogs of nucleobase and nucleoside (NNA) are one of the most widely used classes of therapeutic agents with broad activities as anti-cancer and/or anti-viral agents. NNA drugs are frequently associated with dose-limiting toxicities and their pharmacologic effects vary significantly across patients, and there is a pressing need to understand the biological basis of inter-patient variability in NNA drug response and to develop genetics- based treatment individualization for safe and more effective therapy. Building upon our NIGMS-funded work in the past 5 years focusing on pharmacogenetics of thiopurines, we now propose to expand this program to characterize pharmacogenetic factors related to efficacy and side effects of NNA drugs broadly, e.g., to identify genetic variants linked to antiviral effects of ganciclovir and to characterize the role of human NUDIX enzymes in NNA drug metabolism.

PI_NAMEs: YANG, JUN J. (contact)

PROGRAM_OFFICER_NAME: KODURI, SAILAJA

PROJECT_TERMS: Acyclovir;Address;Adverse effects;anti-cancer;Anti-viral Agents;Anti-viral Therapy;Antineoplastic Agents;Autoimmune Diseases;Biological;Chemicals;Childhood Leukemia;Clinical;clinical development;cytotoxicity;Dose;Dose Limiting;drug metabolism;Drug toxicity;Drug usage;effective therapy;Enzymes;Funding;Ganciclovir;Genes;Genetic;genetic approach;genetic variant;Genotype;Human;interpatient variability;leukemia;Life;Link;Myelosuppression;National Institute of General Medical Sciences;novel;novel therapeutics;nucleobase analog;nucleoside analog;Nucleosides;Nucleotides;Patients;Pharmaceutical Preparations;pharmacogenetic variants;Pharmacogenetics;pharmacologic;programs;Protein Dephosphorylation;Research;response;Role;side effect;Therapeutic Agents;thiopurine;Toxic effect;United States Food and Drug Administration;Variant;Viral;Work

PROJECT_TITLE: Pharmacogenetics of Nucleobase and Nucleoside Analog Drugs

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-T(55)R]


ADMINISTERING_IC: AG

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Prevention;Sleep Research

ORG_CITY: LEXINGTON

ORG_NAME: SIGNAL SOLUTIONS, LLC

ORG_STATE: KY

PHR: Sleep disruption is now recognized not only as an early symptom of Alzheimer’s Disease (AD), but also a contributor to its ongoing development, and thus sleep enhancement is a promising approach to slow the disease. This proposal intends to provide new technology to facilitate preclinical studies in AD model mice, including long term monitoring of behaviors associated with disease progression, and a new method to manipulate and enhance sleep in mice to assess effects on disease and interventions.

PI_NAMEs: O'HARA, BRUCE FREDERICK (contact)

PROGRAM_OFFICER_NAME: MACKIEWICZ, MIROSLAW

PROJECT_TERMS: 3xTg-AD mouse;Abeta clearance;Acceleration;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease patient;Amyloid beta-Protein;Animal Disease Models;Animal Experimentation;Animal Model;Animals;Behavior;Behavior monitoring;behavior test;Behavioral;Brain;Classification;Clinical Research;Collaborations;commercialization;Communities;comorbidity;Companions;Computer software;Consumption;Detection;Development;Devices;Discrimination;Disease;disease model;Disease Progression;Early identification;Early Intervention;Electroencephalography;Electrophysiology (science);Enhancement Technology;Exhibits;feasibility testing;Floor;Funding;Future;glymphatic flow;Goals;Home;Human;improved;improvement on sleep;Industrialization;Intervention;Investigation;Letters;Longitudinal Studies;Measures;mechanical device;Mechanical Stimulation;Mechanics;Memory;Memory Loss;Methods;Modeling;Modification;Molecular;Monitor;mouse model;Mus;Neurodegenerative Disorders;new technology;non rapid eye movement;non-invasive system;Nonpharmacologic Therapy;Operative Surgical Procedures;Outcome;Pathogenicity;Pathology;pharmacologic;Phase;Physiology;Pre-Clinical Model;preclinical study;pressure;prevent;prototype;Rattus;Recording of previous events;Research;Research Personnel;Resources;Rodent;Rodent Model;Running;sensor;sensor technology;side effect;Signal Transduction;Sleep;Sleep Disorders;Sleep disturbances;sleep quality;Small Business Innovation Research Grant;Small Business Technology Transfer Research;software development;Symptoms;System;tau Proteins;Technology;Testing;therapeutic target;Time;tool;Touch sensation;Wakefulness;wasting;Work;Workload

PROJECT_TITLE: Noninvasive sleep enhancement and behavior monitoring technologies for Alzheimer's model mice

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-NV-G(13)B]


NIH_SPENDING_CATS: Lung

ORG_CITY: AUSTIN

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

ORG_STATE: TX

PHR: Project Narrative Motile cilia are small cellular projections that drive the movement of protective mucus in the airways, an essential element of healthy lung physiology. This proposal will explore the molecular and cell biology of motile cilia, thereby shedding light on the etiology of both genetic and acquired lung diseases.

PI_NAMEs: WALLINGFORD, JOHN B (contact)

PROGRAM_OFFICER_NAME: POSTOW, LISA

PROJECT_TERMS: Active Biological Transport;Address;Airway Disease;Architecture;Automobile Driving;Award;base;Biological;Biological Process;Biology;Carrier Proteins;Cell Physiology;Cells;Cellular biology;Cilia;ciliopathy;cilium motility;Cytoplasm;Cytoplasmic Organelle;Data;Data Set;Defect;Development;Diffusion;Disparate;Distal;Dynein ATPase;Elements;Epithelium;Etiology;Eukaryota;experimental study;Failure;Genetic;Genetic Diseases;Goals;Human;Human Genetics;improved;in vivo;Inhalation;innovation;interdisciplinary approach;Left;Light;Link;Lung;Lung Diseases;Maps;Methods;Molecular;Molecular Biology;Molecular Chaperones;Morphogenesis;Motility;Motor;Movement;Mucous body substance;mucus clearance;novel;Organelles;Orthologous Gene;Pathologic;Pathology;Patients;Pattern;Physiology;Play;Process;protein protein interaction;Proteins;Proteomics;Radial;regenerative therapy;repaired;Resolution;Role;Sales;Site;System;Tissues;Work;Xenopus

PROJECT_TITLE: Development and function in mucociliary epithelia

STUDY_SECTION_NAME: Development - 1 Study Section[DEV1]


PHR: Project Narrative  Metalloredox reactions lie at the heart of many key biological processes, from the one electron Fe2+/Fe3+ redox cycle in ferroptosis-associated neurodegenerative diseases and bacterial infection to the multi-electron enzymatic transformations that power biological respiration and the global nitrogen and sulfur cycles, but the structure-function relationships underpinning these phenomena are key gaps in our knowledge that hamper our ability to address significant health challenges. To fill these gaps, we propose to engineer i) novel metal ion sensors for the spatiotemporal imaging of metal ion redox states in biological systems, ii) protein-based structural and functional mimics of complex metalloenzymes responsible for multi-electron reactions, and iii) DNA-cleaving DNAzymes for smaller and more robust alternatives to restriction enzymes and CRISPR/Cas. Achieving these goals will not only advance our knowledge of redox processes in metalloproteins and biological systems, but also expand the toolbox for designing metalloenzymes, real-time diagnostic imaging of mobile metal ions, and customizable recombinant DNA cloning and high-fidelity genome editing.

PI_NAMEs: LU, YI  (contact)

PROGRAM_OFFICER_NAME: SIMONOVIC, MILJAN

PROJECT_TERMS: Address;Affinity;Bacterial Infections;Binding;Biochemical;bioimaging;Biological;Biological Process;biological systems;Catalytic DNA;Cells;Cloning;Clustered Regularly Interspaced Short Palindromic Repeats;cofactor;Complex;copper oxidase;design;Diagnostic Imaging;DNA;ds-DNA;Electrons;Engineering;Enzymes;Exhibits;functional mimics;gene editing technology;Generations;Genetic Engineering;genome editing;Goals;Health;Heart;Heme;heme a;high risk;Image;imaging agent;In Vitro;Individual;insight;Ions;Knowledge;metalloenzyme;Metalloproteins;Metals;Methods;Modeling;Neurodegenerative Disorders;nitric oxide reductase;Nitrogen;novel;Organism;oxidation;Oxidation-Reduction;Peptide Nucleic Acids;Process;Proteins;Reaction;Recombinant DNA;Respiration;restriction enzyme;Role;scaffold;Scaffolding Protein;sensor;spatiotemporal;Specificity;Structure;Structure-Activity Relationship;Sulfite reductase;Sulfur;Time;tool;Tyrosine

PROJECT_TITLE: Design and Selection of Novel Metalloenzymes for Biocatalysis, Bioimaging, and Genetic Engineering

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-P(55)R]


NIH_SPENDING_CATS: Infectious Diseases;Microbiome

ORG_CITY: BIRMINGHAM

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Project Narrative Interactions within bacterial communities are highly regulated by microbial, host, and environmental factors, and these interactions have a significant role in microbial competition and the host response. Reactive nitrogen species (RNS) derived from microbes plays a significant role in the behavior and function of mixed species communities. Using molecular genetics, systems biology tools, and a Drosophila melanogaster model our mechanistic studies will increase our understanding about how RNS production within polymicrobial communities drives bacterial competition and the host response to microbes.

PI_NAMEs: SCOFFIELD, JESSICA A (contact)

PROGRAM_OFFICER_NAME: KEANE-MYERS, ANDREA

PROJECT_TERMS: antimicrobial;Bacteria;bacterial community;Behavior;Biological Response Modifiers;commensal bacteria;Communities;Complex;Data;Development;Drosophila melanogaster;Environment;Environmental Risk Factor;Health;Homeostasis;Immune response;Immunity;Infection;Integration Host Factors;Invertebrates;Knowledge;Life Style;Mediating;metabolomics;Microbe;microbial;microbial community;Microbial Physiology;Modeling;Molecular;Molecular Genetics;Nutrient;Oxygen;pathogen;pathogenic bacteria;Play;Population Dynamics;Production;Proteomics;Reactive Nitrogen Species;Research Proposals;response;Role;Signaling Molecule;Structure;synergism;Systems Biology;tool;transcriptome sequencing

PROJECT_TITLE: Elucidating the role of reactive nitrogen species in bacterial interactions

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-U(55)R]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Aging;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Health Services;Kidney Disease;Prevention;Pulmonary Hypertension

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE Patients with chronic kidney disease carry higher cardiovascular burden, have limited treatment options which often are underutilized. Proposed research projects would advance our understanding of barriers in the adoption of novel therapeutic agents for those with kidney disease and examine new therapeutic options for those with pulmonary hypertension.

PI_NAMEs: NAVANEETHAN, SANKAR DASS  (contact)

PROGRAM_OFFICER_NAME: WEBB, STEPHANIE JOHNSON

PROJECT_TERMS: absorption;Adoption;Affect;Agonist;Albumins;Albuminuria;Angiotensin Receptor;Angiotensin-Converting Enzyme Inhibitors;Area;Biological Markers;burden of illness;Cardiac;Cardiovascular Diseases;cardiovascular risk factor;Cardiovascular system;Chronic Kidney Failure;Clinical;clinical practice;Clinical Practice Guideline;Clinical Research;Clinical Trials;college;Creatinine;Data;Dedications;Diabetes Mellitus;diabetic;Diagnostic;Disease Progression;Documentation;Educational workshop;Eligibility Determination;End stage renal failure;endothelial dysfunction;epidemiology study;Event;experience;Faculty;follow-up;Functional disorder;Future;GLP-I receptor;Glucose;Goals;Guidelines;Health system;Heart Atrium;Heart failure;heart failure with reduced ejection fraction;High Prevalence;Hospitalization;human old age (65+);Hypertension;Hypoglycemic Agents;improved;improved outcome;Inflammation;inhibitor;Institution;interest;International;Intervention Studies;Kidney;Kidney Diseases;Kidney Failure;Leadership;Learning;Left;Lung;lung pressure;Medical Students;Medicine;Mentors;Metabolic Diseases;Midcareer Investigator Award in Patient-Oriented Research;Morbidity - disease rate;mortality;mortality risk;Nephrology;non-diabetic;Non-Insulin-Dependent Diabetes Mellitus;novel therapeutics;Obesity;Outcome;Oxidative Stress;patient oriented research;Patients;Pattern;Pharmaceutical Preparations;Placebos;Population;pressure;professor;pulmonary arterial pressure;Pulmonary Hypertension;Recommendation;Renal dialysis;Renal function;Reporting;Research;Research Activity;Research Infrastructure;Research Personnel;Research Project Grants;research study;Risk;Risk Factors;Risk Reduction;Role;skills;Sodium;symporter;systematic review;Testing;Therapeutic;Therapeutic Agents;Time;Toxin;trial enrollment;Tubular formation;uptake;Uremia;urinary;Vascular calcification;Ventricular;Veterans Health Administration

PROJECT_TITLE: MENTORED PATIENT-ORIENTED RESEARCH TOWARDS OPTIMIZING CARDIOVASCULAR OUTCOMES IN CHRONIC KIDNEY DISEASE

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(MA)]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Drug Abuse (NIDA only);Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Homelessness;Infectious Diseases;Social Determinants of Health;Substance Misuse

ORG_CITY: NEW YORK

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PI_NAMEs: DORAN, KELLY  (contact)

PROGRAM_OFFICER_NAME: WEBB, CANDACE KARONDELETTE

PROJECT_TERMS: 2019-nCoV;Address;Affect;American;Behavior;Black race;care outcomes;caucasian American;Cause of Death;Client;Communicable Diseases;Communities;community partners;comparison group;COVID-19;COVID-19 pandemic;Data;Disease Outbreaks;Environment;Epidemic;Evaluation;experience;expiration;Future;future pandemic;Harm Reduction;Health;health disparity;health service use;Health Services;Health Services Accessibility;Homeless persons;Homelessness;Housing;improved;Individual;innovation;Intervention;Interview;Knowledge;Latinx;Link;Measures;Medicaid;Mental Health;Methods;Modeling;Movement;multidisciplinary;National Institute on Minority Health and Health Disparities;Natural experiment;New York City;Outcome;Overdose;pandemic disease;pandemic response;Pathway interactions;Persons;Pharmaceutical Preparations;Policies;Population;programs;Provider;Quarantine;Research;Research Personnel;response;Scanning;Services;Shelter facility;Social Work;substance use;Substance Use Disorder;substance use treatment;Surveys;Tsunami;Work

PROJECT_TITLE: Crisis Response, Durable Lessons: A Mixed Methods Examination of a Large-Scale Hoteling Intervention for People Experiencing Homelessness During the COVID-19 Pandemic

STUDY_SECTION: CIHB

STUDY_SECTION_NAME: Community Influences on Health Behavior Study Section[CIHB]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Neurosciences;Schizophrenia;Serious Mental Illness

ORG_CITY: BALTIMORE

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: Project Narrative Many people with schizophrenia experience reductions in motivation, which impair occupational functioning, reduce quality of life, and increase public health demands. Recent work has provided strong evidence that abnormal effort-cost decision-making, calculations performed to weigh the “cost vs. benefits” of actions, may be a key contributor to motivational deficits in SZ. This proposal aims to determine the psychological and neural mechanisms of effort-cost decision-making impairment in people with schizophrenia, using computational modeling techniques, to better identify treatment targets.

PI_NAMEs: CULBRETH, ADAM J. (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: Address;analytical method;Anterior;Behavior;behavior measurement;Behavioral;Brain;Choice Behavior;cingulate cortex;Clinical;comparison control;Complex;Computer Models;Computing Methodologies;cost;Data;Decision Making;design;Diagnostic;Equation;Etiology;experience;Functional Magnetic Resonance Imaging;functional MRI scan;Goals;hands on instruction;Impairment;Intervention;Knowledge;Knowledge acquisition;Life;Link;Magnetic Resonance Imaging;Major Depressive Disorder;Mathematics;Measures;Mental disorders;mobile application;mobile computing;Modeling;Motivation;National Institute of Mental Health;neural;neural correlate;neuroimaging;neuromechanism;novel;Occupational;Parameter Estimation;Patient Self-Report;Pattern;Persons;phenomenological models;Phenotype;Positioning Attribute;Prefrontal Cortex;Process;psychologic;Public Health;Quality of life;Research;Research Personnel;response;Rewards;Schizophrenia;Severities;skill acquisition;smartphone based assessment;Specific qualifier value;Specificity;Techniques;Technology;tool;Training;Training Technics;translational impact;Ventral Striatum;Work

PROJECT_TITLE: Computational Mechanisms of Effort-Cost Decision-Making in Schizophrenia

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Aging;Autoimmune Disease;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Eye Disease and Disorders of Vision;Immunotherapy;Prevention;Rare Diseases;Women's Health Research

ORG_CITY: IOWA CITY

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: PROJECT NARRATIVE Sjögren disease is a complex, chronic autoimmune disease that leads to severe dry mouth with complications due to poor oral health and severe dry eye disease with potential for vision- threatening complications. Despite being one of the most common autoimmune rheumatologic diseases, affecting up to 4 million Americans, the cause of Sjögren disease is unknown. The goal of this research is to define the mechanisms by which the immune system is driven to attack saliva producing glands–the hallmark of Sjögren disease–which will lead to better early diagnostic tests and new treatments for this and other autoimmune diseases.

PI_NAMEs: LIEBERMAN, SCOTT MATTHEW (contact)

PROGRAM_OFFICER_NAME: CHANDER, PREETHI

PROJECT_TERMS: Address;Adoptive Transfer;Affect;American;Antigen-Presenting Cells;Autoimmune;Autoimmune Diseases;Autoimmune Process;autoimmune rheumatologic disease;Autoimmunity;Automobile Driving;Bone Marrow;Cells;Characteristics;Chimera organism;chronic autoimmune disease;Complex;conditional knockout;cytokine;Data;Dendritic Cells;Development;diabetic;Diagnosis;Diagnostic;diagnostic biomarker;Diagnostic tests;disability;Disease;disease model;Dry Eye Syndromes;Early Diagnosis;effective therapy;Epithelial Cells;Event;Female;Functional disorder;Future;Genes;genetic variant;Gland;Goals;Histologic;Human;Immune;Immune mediated destruction;Immune signaling;Immune system;Immunologics;immunomodulatory therapies;In Vitro;in vivo;Inbred NOD Mice;Individual;Inflammation;Inflammatory;inhibitor;insight;Interleukin-12;interleukin-23;Knock-out;Knowledge;Lacrimal gland structure;Lymphocyte;Macrophage;Mediating;Modeling;Monoclonal Antibodies;mouse model;Mouse Strains;Mus;Natural Killer Cells;Non obese;Oral health;Outcome;Pathogenesis;Phenotype;prevent;protective effect;Protein Tyrosine Kinase;Proteins;Quality of life;Research;Resistance;Role;Saliva;Salivary Gland Diseases;Salivary Glands;Sialadenitis;Signal Transduction;Sjogren's Syndrome;T-Lymphocyte;targeted treatment;Testing;treatment effect;TYK2;Vision;Xerostomia

PROJECT_TITLE: Tyk2 and Associated Cytokines in Salivary Gland Autoimmunity

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]


ADMINISTERING_IC: AR

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: Aurora

ORG_DEPT: ORTHOPEDICS

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Narrative This application herein describes a new T32 Training Program at the University of Colorado entitled “Interdisciplinary Training in Musculoskeletal Research” requesting support for 4 predoctoral and 2 postdoctoral trainees. The overarching mission of the Program is to provide comprehensive interdisciplinary training in musculoskeletal science with the aim of developing the next generation of outstanding musculoskeletal investigators.

PI_NAMEs: PAYNE, KARIN A;ZUSCIK, MICHAEL J (contact)

PROGRAM_OFFICER_NAME: VINCENT, ISAAH S

PROJECT_TERMS: Musculoskeletal;Research;Training


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Drug Abuse (NIDA only);Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Medication treatments for opioid use disorder (MOUD) are the most effective tools for improving outcomes and preventing overdose among persons with OUD. However, there is a significant discrepancy between MOUD effectiveness achieved in clinical trials and in real world settings-what NIDA has termed the research-to- practice gap-which may be partially attributable to differences between clinical trial populations and those in the real world. In this work, we will unite design and analytic strategies to bridge MOUD trial evidence to target populations by: 1) empirically identifying those individuals not represented or under-represented in MOUD trials, and 2) accurately and reliably generalizing expected MOUD effects on treatment retention to the adult Medicaid population, with the broad goal of optimizing the generalizability and policy-relevance of future clinical trials.

PI_NAMEs: RUDOLPH, KARA ELIZABETH (contact);STUART, ELIZABETH A.

PROGRAM_OFFICER_NAME: SU, SHELLEY

PROJECT_TERMS: Acceleration;Accountability;Address;Adoption;Adult;Buprenorphine;California;care seeking;Cessation of life;Characteristics;Clinical;clinical trial participant;Clinical Trials;Clinical Trials Network;comorbidity;comparative treatment;COVID-19 pandemic;Data;data harmonization;Decision Making;design;Dimensions;Dose;Effectiveness;Ensure;Ethnic Origin;evidence base;experience;Foundations;Future;Goals;Immigration;improved;improved outcome;Incentives;Individual;Injections;Left;Medicaid;medication for opioid use disorder;Methadone;Methods;Morbidity - disease rate;mortality;Naltrexone;National Institute of Drug Abuse;New Jersey;opioid epidemic;opioid use disorder;Outcome;Output;Overdose;Overdose reduction;Participant;patient population;Patients;Persons;Pharmaceutical Preparations;Phase;Physiologic Ossification;Policies;Policy Maker;Population;Population Characteristics;prevent;Process;Provider;public health emergency;Race;Recovery;relative effectiveness;Research;Research Personnel;research to practice;sociodemographics;Software Tools;Subgroup;substance use;Target Populations;Time;tool;treatment as usual;treatment effect;Treatment Effectiveness;trial design;Underrepresented Populations;user friendly software;Vehicle crash;Visualization;Work

PROJECT_TITLE: Design and analysis advances to improve generalizability of clinical trials for treating opioid use disorder

STUDY_SECTION: HSQE

STUDY_SECTION_NAME: Health Services: Quality and Effectiveness Study Section[HSQE]


ADMINISTERING_IC: DK

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Bioengineering;Diabetes;Pediatric;Prevention;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Transplantation

ORG_CITY: ATLANTA

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: GEORGIA INSTITUTE OF TECHNOLOGY

ORG_STATE: GA

PHR: PROJECT NARRATIVE β-cells derived from human stem cells represent a transformative, unlimited source of insulin-producing cells for the treatment of type 1 diabetes, but translation of these cells is hindered by the lack long-term engraftment and function without chronic immunosuppression and use of encapsulation devices that limit engraftment. The objective of this project is to engineer advanced biomaterial delivery technologies to (i) enhance vascularization, survival, and engraftment of SC-β cells and (ii) protect them from rejection by the immune system without the need for encapsulation or chronic immunosuppression.

PI_NAMEs: GARCIA, ANDRES J (contact);LEI, JI ;SHIRWAN, HAVAL

PROGRAM_OFFICER_NAME: ARREAZA-RUBIN, GUILLERMO

PROJECT_TERMS: Acceleration;Adult;Affect;Animal Model;Autoimmune Diseases;Beta Cell;Biocompatible Materials;Blood Glucose;Body Weight;C-Peptide;Cadaver;Cell Physiology;cell replacement therapy;Cell Survival;Cell Transplantation;Cells;Child;Chronic;Clinical;clinical translation;Clinical Trials;Collagen;Complications of Diabetes Mellitus;delivery vehicle;Development;Devices;diabetes risk;diabetic;Disease;Encapsulated;Engineering;Engraftment;euglycemia;Fasting;Formulation;Future;Gel;Glucose tolerance test;glycemic control;graft function;Graft Survival;Health Care Costs;Homologous Transplantation;Human;human pluripotent stem cell;human stem cells;humanized mouse;Hydrogels;Hypoglycemia;hypoglycemia unawareness;Immune;Immune Evasion;Immune system;Immunocompetent;Immunocompromised Host;Immunologics;Immunology;immunoregulation;Immunosuppression;improved;Injectable;innovation;Insulin;Insulin-Dependent Diabetes Mellitus;islet;Islets of Langerhans Transplantation;Lead;Modeling;Monitor;mouse model;Mus;nephrotoxicity;nonhuman primate;Patients;Pilot Projects;prevent;Prevention;response;Risk;SCID Beige Mouse;Signal Transduction;Site;Source;stem cell biology;Structure of beta Cell of islet;subcutaneous;Technology;Translations;Transplantation;Vascular Endothelial Growth Factors;Vascularization;Vasculogenic;Work

PROJECT_TITLE: Hydrogels for human beta cell survival, function and evasion of immune rejection


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cardiovascular;Genetics;Heart Disease;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: FARMINGTON

ORG_NAME: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT

ORG_STATE: CT

PHR: PROJECT NARRATIVE Cardiomyopathy patients are at risk for sudden cardiac death and progressive heart failure, but improving treatments depends on our learning more about how heart function is perturbed by specific mutations in ‘titin,’ a key protein controlling the contraction of heart muscle. Our research will reveal how a series of titin mutations cause heart failure by determining how they change contraction of engineered heart tissues (which are models of human heart muscle) and how they change the levels of titin protein and other proteins important to the heart. This research has the potential to reveal patient-specific insights into cardiomyopathy disease development and lead to new treatments that prevent heart failure.

PI_NAMEs: CAMPBELL, STUART G;HINSON, JOHN TRAVIS (contact)

PROGRAM_OFFICER_NAME: ADHIKARI, BISHOW B

PROJECT_TERMS: 3-Dimensional;Adrenergic Agents;adverse outcome;Agar Gel Electrophoresis;Alternative Splicing;Base Pairing;Behavior;biological adaptation to stress;Biological Assay;Biology;biomarker development;biomarker identification;Biomimetics;Cardiac;Cardiac Myocytes;cardiac tissue engineering;Cardiomyopathies;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;Communities;Computing Methodologies;confocal imaging;connectin;CRISPR-mediated transcriptional activation;CRISPR/Cas technology;Data;Dependence;Development;Diagnosis;Dilated Cardiomyopathy;Disease;disease prognosis;Distal;DNA;dosage;Dose;Extracellular Matrix;Fibroblasts;Functional disorder;Future;Genes;Genetic;genome editing;Goals;Guide RNA;Heart;heart cell;heart dimension/size;Heart failure;heart function;Heterozygote;high risk;Human;human induced pluripotent stem cells;human model;improved;Individual;induced pluripotent stem cell;induced pluripotent stem cell derived cardiomyocytes;inherited cardiomyopathy;insight;Kinetics;Knowledge;Learning;Length;Lesion;Link;Location;Measures;Mechanics;mechanotransduction;Mediating;Methods;Modeling;Molecular;Mus;Mutation;mutation carrier;Myocardial Contraction;Myocardium;Nonmuscle Myosin Type IIA;Organelles;Pathogenesis;Pathogenicity;Pathologic;Pathway interactions;Patients;Phenotype;Physicians;Physiological;prevent;Prognosis;promoter;Protein Isoforms;Proteins;proteostasis;Publications;Reagent;Regulation;Regulatory Element;Research;Resources;response;Risk;RNA Binding;Sarcomeres;scaffold;Series;Signal Transduction;Site;Stress;Structure;Sturnus vulgaris;sudden cardiac death;Sudden Death;Technology;Therapeutic;therapeutic development;therapeutic target;Tissue Engineering;Tissue Model;Tissue-Specific Gene Expression;Transcription Coactivator;transcriptomics;Variant;Western Blotting;Work

PROJECT_TITLE: Establishing and reversing the functional consequences of Titin truncation mutations

STUDY_SECTION: MPPA

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology A Study Section [MPPA]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Services;Patient Safety

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project Narrative Over 7 million adults older adults are hospitalized in the US annually and older adults are often discharged with changes to medications for chronic conditions which are not directly related to their reason for hospitalization. In current practice, neither prior chronic disease control nor key geriatric issues such as multimorbidity, polypharmacy, or cognition appear to influence discharge prescribing decisions, thus, there is an urgent need to reorient the current approach to hospital management of older adults’ chronic conditions from a number- driven to a patient-centered decision-making process. With this proposed project, we will develop and pilot test an innovative clinical decision framework which will incorporate geriatric principles to individualize chronic medication discharge prescribing decisions for hospitalized older adults, thereby improving the health and wellbeing of older adults in the peri-hospitalization period.

PI_NAMEs: ANDERSON, TIMOTHY S (contact)

PROGRAM_OFFICER_NAME: SALIVE, MARCEL

PROJECT_TERMS: Acute;Address;Adult;Adverse drug event;Adverse Drug Experience Report;Aging;Awareness;Benefits and Risks;Blood Glucose;Blood Pressure;Caring;Chronic;Chronic Disease;Clinical;Cognition;Cohort Studies;Communication;Consensus;Data;Decision Making;design;Development;Diabetes Mellitus;Disease Management;disorder control;Elderly;Electronic Health Record;experience;Face;Feedback;Focus Groups;functional decline;Geography;Geriatrics;Goals;Guidelines;Health;Health Surveys;Hospital Administration;hospital readmission;Hospitalists;Hospitalization;Hospitals;human old age (65+);Hypertension;Impaired cognition;implementation framework;improved;innovation;inpatient service;Inpatients;Intervention;Israel;Knowledge;Learning;Life Expectancy;Literature;Measures;Medical center;Medicine;Mentors;Methods;multiple chronic conditions;novel;older adult;Participant;patient oriented;Patient Outcomes Assessments;Patient-Focused Outcomes;Patients;Personal Satisfaction;personalized approach;personalized decision;Pharmaceutical Preparations;Pharmacoepidemiology;pilot test;Polypharmacy;Positioning Attribute;Pre-Post Tests;primary care clinician;Process;Prognosis;prospective;Prospective, cohort study;randomized trial;Reporting;Research;Research Support;Risk;Safety;Self Efficacy;shared decision making;skills;Testing;therapy development;tool;treatment guidelines

PROJECT_TITLE: Optimizing prescribing decisions for hospitalized older adults with chronic conditions


NIH_SPENDING_CATS: Clinical Research;Genetics;Hematology;Infectious Diseases;Precision Medicine;Sepsis

ORG_CITY: PROVIDENCE

ORG_NAME: RHODE ISLAND HOSPITAL

ORG_STATE: RI

PHR: Project Narrative Sepsis is responsible for 20% of deaths worldwide. We propose to use advanced computational biology approaches with deep RNA sequencing data to improve the diagnosis and treatment of sepsis.

PI_NAMEs: MONAGHAN, SEAN FARRELL (contact)

PROGRAM_OFFICER_NAME: ZHAO, XIAOLI

PROJECT_TERMS: Alternative Splicing;anti-PD1 antibodies;Bacteria;Biology;Caring;Cells;Cessation of life;comparison control;Computational Biology;Computer Analysis;Computing Methodologies;Critical Illness;Data;Diagnosis;diagnostic value;Disease;Entropy;Event;Excision;Exons;Functional disorder;Genes;Genetic Transcription;Human;Immune response;improved;Intensive Care Units;Intervention;Introns;Joining Exons;microbial;Molecular;new therapeutic target;novel;Outcome;outcome prediction;pathogen;Patients;Population;potential biomarker;precision medicine;Proteins;Resources;RNA;RNA metabolism;RNA Splicing;Sampling;Sepsis;septic patients;transcriptome sequencing;Translations;Triage;Virus;Whole Blood

PROJECT_TITLE: Improving Sepsis Care with Deep RNA Sequencing Data

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-K(55)R]


ADMINISTERING_IC: AI

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics;Human Genome;Infectious Diseases;Machine Learning and Artificial Intelligence

ORG_CITY: Princeton

ORG_NAME: PRINCETON UNIVERSITY

ORG_STATE: NJ

PHR: Project Narrative T cells coordinate systemic immunity and are essential for defense against pathogens. Systematic molecular analysis of T cells and of T cell interactions with other cell types across tissues is fundamentally important for better understanding of mechanisms of the adaptive immune system and critical for developing better T cell modulation therapies for infectious diseases and autoimmunity. The goal of our research program is to employ innovative experimental genomics to build multi-dimensional data resources and develop new computational algo- rithms that we will use to obtain a comprehensive molecular understanding of T cell activation and differentiation in response to various stimuli across biological contexts in mouse and human.

PI_NAMEs: PRITYKIN, YURY  (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Adaptive Immune System;adaptive immunity;Address;Age;Architecture;Autoantigens;Autoimmunity;Bacterial Infections;Biological;Biological Assay;CD8-Positive T-Lymphocytes;Cell Communication;Cell Lineage;Cell Physiology;cell type;Cells;Chromatin;Clinical;cofactor;cohort;Collaborations;Communicable Diseases;comparative;Computational algorithm;Computer Analysis;Computer software;Computing Methodologies;Data;data exploration;data resource;Databases;Disease;Environmental Risk Factor;epigenetic regulation;FOXP3 gene;Future;Gender;Gene Expression;Generations;genomic data;Genomics;Genotype;Goals;Heterogeneity;Hi-C;Human;humanized mouse;Hypersensitivity;Immunity;immunodeficiency;Immunologics;improved;innovation;Life Style;Lymphocytic choriomeningitis virus;Machine Learning;machine learning method;Maintenance;Malignant Neoplasms;Maps;Methods;microbiota;Modeling;Molecular;Molecular Analysis;mouse model;multidimensional data;multiple omics;Mus;Noise;novel therapeutics;pathogen;Population;prevent;Process;progenitor;programs;Property;Recording of previous events;Regulation;Regulatory T-Lymphocyte;Reporting;Research;research and development;Resolution;response;Role;single cell ATAC-seq;Stimulus;supervised learning;System;T cell regulation;T-Cell Activation;T-Lymphocyte;Therapeutic;Tissues;transcription factor;Transcriptional Regulation;transcriptome sequencing;translational applications;translational barrier;tumor;Validation;Virus Diseases

PROJECT_TITLE: Regulatory genomics of T cells in mouse and human


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_DEPT: CHEMISTRY

ORG_NAME: GEORGIA STATE UNIVERSITY

PHR: The arenavirus family of the Bunyavirales order includes old world arenaviruses (such as Lassa fever virus and lymphocytic choriomeningitis virus) and new world viruses (such as Wachupo virus, Pichinde virus and Junin virus). These animal-borne viruses cause hemorrhagic fevers in humans and may result in a future pandemic. The proposed structural and functional studies of lymphocytic choriomeningitis virus facilitates development of vaccines and antiviral agents against arenaviruses.

PI_NAMEs: LUO, MING  (contact);ZHOU, Z HONG

PROGRAM_OFFICER_NAME: DUPUY, LESLEY CONRAD

PROJECT_TERMS: Acceleration;Animals;Anti-viral Agents;Architecture;Arenavirus;Basic Science;Binding;Binding Proteins;Bunyavirales;Cell membrane;Cells;Collaborations;Complex;COVID-19 pandemic;Cryo-electron tomography;Cryoelectron Microscopy;Data;density;Density Gradient Centrifugation;Deposition;design;Disease Outbreaks;experimental study;Family;Future;future pandemic;Genetic Transcription;genomic RNA;Genomic Segment;Glycoproteins;GP2 gene;GTPBP1 gene;Human;human pathogen;Image;image reconstruction;In Situ;Individual;innovation;insight;Joints;Junin virus;Knowledge;Lassa virus;Lymphocyte Function;Lymphocytic choriomeningitis virus;Measures;member;Membrane;Messenger RNA;Methods;Modeling;Molecular;Mutation;novel;novel strategies;Nucleocapsid;Nucleoproteins;Old World Arenaviruses;pathogen;Peptide Signal Sequences;Pichinde virus;plasma protein Z;Polymerase;Proteins;prototype;Public Health;recombinant virus;reconstruction;recruit;Resolution;RNA;RNA chemical synthesis;RNA Sequences;RNA Viruses;RNA-Directed RNA Polymerase;RNA-Protein Interaction;Rodent;Series;Signal Transduction;social;structural biology;Structure;Structure-Activity Relationship;System;Techniques;Technology;Testing;three dimensional structure;three-dimensional modeling;Tomogram;Ultracentrifugation;vaccine development;Vaccines;Vesicular stomatitis Indiana virus;Viral;Viral Hemorrhagic Fevers;Viral Proteins;viral RNA;Virion;Virus;Virus Assembly;X-Ray Crystallography;Zoonoses

PROJECT_TITLE: Study of arenavirus assembly


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Neurosciences;Social Determinants of Health

ORG_NAME: NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC

PHR: PROJECT NARRATIVE Early life stress greatly increases the risk for developing psychiatric illness later in life. We seek to understand the mechanism of this increased risk by studying neural circuitry changes induced by early life stress during anxiety-related and reward-seeking behaviors. The long-term goal of this work is to improve our understanding of environmental risk factors for mental illness and find ways to reduce vulnerability in affected populations.

PI_NAMEs: CHANG, WEI-LI  (contact)

PROGRAM_OFFICER_NAME: VAN'T VEER, ASHLEE VICTORIA

PROJECT_TERMS: 3-Dimensional;Academic Medical Centers;Acceleration;Adult;Affect;Anhedonia;Animal Model;Anxiety;anxiety-like behavior;Area;Bathing;Beds;Behavior;Behavior assessment;behavior test;Behavioral;Biological Assay;Brain;brain tissue;Calcium;calcium indicator;career;Caring;Cell Count;Cell Density;Cell Physiology;cell type;Cells;Chronic stress;Computational Technique;Computer Analysis;conditioned fear;density;Development;Dorsal;early life stress;Emotional;emotional behavior;Environment;Environmental Risk Factor;Equilibrium;exposed human population;Exposure to;FOS gene;Foundations;Fright;Functional disorder;Future;gene product;Goals;Hippocampus;Image;Immediate-Early Genes;improved;in vivo;in vivo calcium imaging;insight;Interneurons;K-Series Research Career Programs;Learning;Life;Light;Measures;Mediating;Mental disorders;Mentorship;microendoscopy;microscopic imaging;Microscopy;Modeling;mouse model;Mus;neural;neural circuit;neurodevelopment;Neurons;New York;Noise;Opsin;optogenetics;Output;Parvalbumins;Pattern;Phase;Physicians;Physiology;Population;postnatal period;Psychiatry;Pyramidal Cells;Research;Research Personnel;resilience;Resolution;response;reward processing;Rewards;Risk;Risk Factors;Rodent;Rodent Model;Scientist;Signal Transduction;Stimulus;Synapses;Testing;therapeutic target;Time;Tissues;Training;Transgenic Mice;Universities;Work

PROJECT_TITLE: Early Life Stress Effects on Ventral Hippocampal Microcircuitry during Emotional Behaviors

STUDY_SECTION: PMDA

STUDY_SECTION_NAME: Pathophysiological Basis of Mental Disorders and Addictions Study Section[PMDA]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: Los Angeles

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

ORG_STATE: CA

PHR: The mission of the Center for Advancing Sociodemographic and Economic Study of Alzheimer’s Disease and Related Dementias (CeASES‐ADRD) is to advance innovative social science ADRD research, to increase knowledge and technical capability of social science researchers, to broaden and diversify the set of researchers working in the field and, to disseminate resources and communicate findings for impact. CeASES‐ADRD targeted research themes are social and economic burden of ADRD over the life course, and national and international trends and projections of ADRD and were chosen to fill research gaps of some of the most pressing and immediate challenges of ADRD and to align with multiple NIA Strategic Directions. CeASES‐ADRD strengths include: (1) a multidisciplinary research team from University of Southern California, University of Texas, Austin, and Stanford; (2) the development of a unique set of interrelated programs hosted over 2.5 days each year including the Science of ADRD for Social Scientists program, ADRD research network meetings, and methodological and technical workshops; and (3) the uniting of key resources including USC Schaeffer Center’s external affairs staff for dissemination of findings, a research programming staff and data librarian for technical support and expertise, and multiple NIA‐funded Centers including a Resource Center for Minority Aging Research, an Alzheimer’s Disease Research Center and a Roybal Center in Health Policy Simulation for network building and driving innovative science.

PI_NAMEs: BHATTACHARYA, JAY ;GOLDMAN, DANA P;HAYWARD, MARK D.;ZISSIMOPOULOS, JULIE M (contact)

PROGRAM_OFFICER_NAME: NOVAK, PRISCILLA JOY

PROJECT_TERMS: Address;Affect;Aging;Algorithms;Alzheimer's Disease;Alzheimer's disease related dementia;Area;Automobile Driving;base;Behavior;California;care costs;Caregivers;Collaborations;Communication;Communities;cost;cost of dementia;Data;Data Sources;Dementia;Development;Economic Burden;economic cost;economic outcome;Economics;Educational workshop;Ensure;Ethnic Origin;Evaluation;Event;experience;Faculty;Family;Family member;Fostering;Funding;Generations;Health;health care service organization;Health Policy;Health Services Accessibility;Healthcare;Healthcare Systems;Heterogeneity;improved;Individual;informal care;innovation;insight;Interdisciplinary Study;International;Knowledge;Leadership;Librarians;Life Cycle Stages;longitudinal dataset;Longitudinal Surveys;meetings;Mentors;Mentorship;Methodology;Minority;Mission;Modeling;models and simulation;multidisciplinary;next generation;Outcome;outreach;payment;Personal Satisfaction;Persons;Pharmacotherapy;Physicians;Policies;Population;Population Research;prevent;programs;Race;Research;research data dissemination;Research Personnel;Research Support;Resources;Risk;Science;Scientist;simulation;social;social science research;Social Sciences;Societies;sociodemographics;socioeconomic disparity;Structure;success;System;Targeted Research;Technical Expertise;Texas;therapy development;Time;transmission process;trend;United States National Institutes of Health;Universities;web portal

PROJECT_TITLE: Center for Advancing Sociodemographic and Economic Study of Alzheimer's Disease and Related Dementias (CeASES-ADRD)


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Services;Neurodegenerative;Neurosciences;Prevention;Social Determinants of Health

PHR: See Overall – per RFA, DO NOT COMPLETE. This is being uploaded to remove the error under the eRA System.

PI_NAMEs: ZISSIMOPOULOS, JULIE M (contact)

PROJECT_TERMS: Aging;Alzheimer's Disease;Alzheimer's disease related dementia;analytical tool;Arts;Automobile Driving;Collaborations;Communication;Data;Demographer;Demography;design;Economics;Ensure;Evaluation;experience;Faculty;Funding;Generations;Gerontology;health care delivery;health economics;health management;Health Policy;Health Promotion;Incubated;innovation;interest;Leadership;Letters;Life Cycle Stages;Medicine;Methods;Minority;Mission;National Institute on Aging;news;Personal Satisfaction;Pharmacy facility;Policies;population health;Population Research;programs;Public Policy;Reporting;Research;Research Personnel;Research Support;Resources;Science;Scientist;simulation;social;Social Environment;sociodemographics;Structure;System;Texas;Universities

PROJECT_TITLE: Center for Advancing Sociodemographic and Economic Study of Alzheimer’s Disease and Related Dementias (CeASES-ADRD)


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Social Determinants of Health

PI_NAMEs: CRIMMINS, EILEEN M (contact)

PROJECT_TERMS: Abbreviations;Address;Alzheimer's disease related dementia;Applications Grants;Area;California;Caring;Cognition;Cognitive;Data;data library;data resource;Data Sources;design;Diagnosis;Economic Burden;Economics;Education;Educational workshop;Ensure;Foundations;Future;Guidelines;Home;human subject;improved;innovation;Institution;International;Life Cycle Stages;Link;Measures;meetings;Modeling;models and simulation;Monitor;multidisciplinary;payment;Pilot Projects;Policies;Program Development;programs;recruit;Regulation;Research;Research Personnel;Research Project Grants;Safety;Science;Scientist;screening;social;social science research;Social Sciences;sociodemographics;success;System;Texas;trend;Universities


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Social Determinants of Health

PROJECT_TERMS: Abbreviations;Address;Adoption;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;analytical method;base;Behavior Therapy;biodemography;Biological;California;career development;Collaborations;Communities;Data;data sharing;Data Sources;Decision Making;Demography;design;Development;Economics;Educational workshop;Elderly;Environment;Evaluation;experience;Faculty;Foundations;Funding;Health;health economics;Health Policy;Healthcare;human old age (65+);improved;innovation;interdisciplinary collaboration;Interdisciplinary Study;International;Link;meetings;Memory Loss;Mentorship;Minority;models and simulation;multidisciplinary;National Institute on Aging;older adult;outreach;Personal Satisfaction;Policies;Policy Developments;Population;population health;Population Research;Production;programs;Recording of previous events;Research;Research Personnel;Research Support;Resources;Science;Scientist;senior faculty;Series;simulation;social;social science research;Social Sciences;sociodemographics;sound;Surveys;System;Texas;Translations;trend;Universities


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Hypertension;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research

ORG_CITY: NEW ORLEANS

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: Project Narrative The burden of hypertension and related cardiovascular disease, stroke, and end-stage kidney disease is disproportionally high in Black populations, especially in the South. This cluster randomized trial will test the effectiveness, implementation, and sustainability of a church wellness coordinator-led multifaceted intervention compared to enhanced usual care on hypertension control in Black communities. This study will generate evidence on an effective, scalable, and sustainable strategy for eliminating hypertension disparities in Black communities.

PI_NAMEs: FERDINAND, KEITH COPELIN;HE, JIANG  (contact);MILLS, KATHERINE TERESA

PROGRAM_OFFICER_NAME: BARKSDALE, CRYSTAL

PROJECT_TERMS: Adoption;Adult;Anti-Hypertensive Agents;Black church;Black Populations;Black race;Blood Pressure;blood pressure control;Cardiovascular Diseases;care coordination;Case Management;Church;Clinical;Clinical effectiveness;Cluster randomized trial;Communities;community advisory board;community based participatory research;community engagement;Community Health Aides;community intervention;community organizations;Community Pharmacy;comparison intervention;Control Groups;cost effectiveness;Cost Effectiveness Analysis;Data;design;Development;Disparity;Effectiveness;effectiveness outcome;effectiveness testing;effectiveness/implementation design;Eligibility Determination;End stage renal failure;Ethnic Population;Evidence based intervention;Exercise;Exploration, Preparation, Implementation, and Sustainment;Faith-based organization;Federally Qualified Health Center;follow-up;Follow-Up Studies;General Population;Guidelines;Health;Health care facility;health care quality;health care service organization;health disparity;Health education;Health Food;Health Personnel;Health Policy;health training;Healthcare Systems;High Prevalence;Home Blood Pressure Monitoring;Hypertension;hypertension control;hypertension treatment;implementation evaluation;implementation outcomes;implementation strategy;improved;Individual;Intention;Intervention;intervention program;Life Style;Life Style Modification;Louisiana;Measurement;medication compliance;member;mortality;multi-component intervention;Needs Assessment;Outcome;Participant;Patient Care;Patients;Pharmaceutical Preparations;post intervention;Prevalence;Primary Care;primary care provider;primary outcome;Protocols documentation;Provider;Public Health;racial population;Randomized;Reach, Effectiveness, Adoption, Implementation, and Maintenance;recruit;screening;Side;Stroke;Testing;Training;treatment as usual;treatment comparison;Trust;Visit;Wellness Program;Work

PROJECT_TITLE: Church Wellness Coordinator-led Intervention to Improve Hypertension Control in the Black Community


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Social Determinants of Health

PI_NAMEs: GOLDMAN, DANA P (contact)

PROJECT_TERMS: Abbreviations;Aging;Algorithms;Alzheimer's Disease;Alzheimer's disease related dementia;analytical tool;arm;Behavior Therapy;biodemography;Biological;Collaborations;Communities;Data;Data Collection;data resource;Decision Making;design;Discipline;District of Columbia;Economics;Educational workshop;Elderly;Ensure;Environment;Evaluation;Event;experience;Funding;Future;Health;health economics;Health Policy;human old age (65+);improved;innovation;Institution;International;Memory Loss;Mentorship;Minority;Modeling;models and simulation;older adult;Outcome;Personal Satisfaction;Policies;Policy Maker;Population;population health;programs;Research;Research Personnel;Resources;Scientist;simulation;social;sociodemographic factors;sociodemographics;success;System;therapy development;Translating;Translational Research;United States National Institutes of Health;web portal


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Cancer;Colorectal Cancer;Dementia;Digestive Diseases;Genetics;Microbiome;Neurodegenerative

ORG_CITY: BOSTON

ORG_DEPT: PATHOLOGY

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

ORG_STATE: MA

PHR: Project Narrative Many of the diseases of old age like cancer and Alzheimer’s disease, as well as the process of aging itself, have been linked to changes in the composition of microbes in our gut. In addition, the ability of our gut to keep toxic microbial fragments out of our bloodstream declines with advanced age and results in inflammation. We have discovered a normal gut bacterium called Parabacteroides distasonis (Pd) that strengthens the gut barrier and blocks inflammation in mice and extends lifespan in fruit flies – we now seek to understand whether Pd can extend lifespan and healthspan in mice and gain a comprehensive understanding of how it works.

PI_NAMEs: CROTT, JIMMY W (contact)

PROGRAM_OFFICER_NAME: FLORES, ROBERTO L

PROJECT_TERMS: Ablation;Address;Adherent Culture;Affect;Age;age acceleration;age related;age related changes;age related decline;age-related disease;Aging;aging process;Alzheimer's Disease;anti aging;Anti-Inflammatory Agents;Attention;Bacteria;Bacterial Antigens;Bacterial Toxins;Bacteroides;beneficial microorganism;Blood Circulation;Cardiovascular Diseases;Cells;Chronic Disease;Cloning;Co-Immunoprecipitations;Cognitive;cognitive function;Colon;Colorectal Cancer;commensal bacteria;comparative genomics;Dementia;Deterioration;Diet;Diffusion;Disease;drivers of aging;Drosophila genus;Ecosystem;Elderly;Encephalitis;Exclusion;experimental study;extend lifespan;Extravasation;fly;frailty;Functional disorder;gastrointestinal epithelium;Genes;genetic manipulation;Goals;gut bacteria;gut inflammation;gut microbes;gut microbiota;hallmarks of aging;Health;healthspan;Homologous Gene;Human;human old age (65+);In Vitro;in vivo;Inflammation;Inflammatory;innovation;intestinal barrier;Intestinal Mucosa;Intestinal permeability;Intestines;Knowledge;Life;life span;Link;Longevity;loss of function;Maintenance;Malignant Neoplasms;Measures;Memory;Metabolic syndrome;Microbe;microbial;Mus;Mutate;novel;Outcome;Penetration;Persons;Physical Function;Play;Population;preservation;prevent;Proteins;Recombinants;Role;sensor;success;Testing;Tight Junctions;TLR4 gene;Translations;Up-Regulation;Vertebrates;Work

PROJECT_TITLE: Strengthening gut barrier integrity with beneficial microbes to increase lifespan and healthspan

STUDY_SECTION: CMAD

STUDY_SECTION_NAME: Cellular Mechanisms in Aging and Development Study Section[CMAD]


ORG_CITY: MINNEAPOLIS

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative Minnesota Muscle is a training program in basic and translational muscle research, for both predoctoral and postdoctoral trainees. The program has been extremely successful in its first 20 years, as measured by the publications and research career trajectories of past predoctoral and postdoctoral trainees. Recent additions of outstanding faculty and core facilities have improved an already stellar training program.

PI_NAMEs: ERVASTI, JAMES M;LOWE, DAWN A;THOMAS, DAVID D (contact)

PROJECT_TERMS: Minnesota;Muscle;Training Programs

PROJECT_TITLE: Minnesota Muscle Training Program


NIH_SPENDING_CATS: Genetics

ORG_DEPT: BIOLOGY

ORG_NAME: EMORY UNIVERSITY

PHR: PROJECT NARRATIVE Centromeric satellites and their binding protein partners are engaged in an evolutionary arms race such that each side is continuously evolving. As a result, centromeres are one of the most divergent genomic elements in geographically isolated populations, which ultimately lose the ability to exchange genetic material and become two species. Our evolutionary-guided approach investigates the role of centromere divergence in forging the reproductive barriers (male hybrid infertility) between populations using genomics, cell biology and genetics.

PI_NAMEs: THAKUR, JITENDRA  (contact)

PROGRAM_OFFICER_NAME: VATAKIS, DIMITRIOS NIKOLAOS

PROJECT_TITLE: R35 Investigating rapidly evolving centromeres and their role in the reproductive isolation in mammals

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-GGG-S(55)]


NIH_SPENDING_CATS: Cardiovascular

ORG_DEPT: PHYSIOLOGY

PHR: PROJECT NARRATIVE The CURS program addresses the lack of diversity in biomedical research, which is rooted in the limited number of under-represented students entering the field of science, ultimately affecting the goals and direction of research. Underserved communities suffer from a lack of representation at the decision-making level in science, in terms of policy issues and the determination of priorities for conducting research. Therefore, the CURS program addresses the critical need to increase the pipeline of highly qualified trainees into cardiovascular science.

PI_NAMEs: MARKS, ANDREW ROBERT (contact)

PROGRAM_OFFICER_NAME: MEADOWS, TAWANNA

PROJECT_TERMS: Address;Affect;Bachelor's Degree;Basic Science;biological research;Biology;Biomedical Research;Biophysics;California;Cardiovascular system;career;career development;Cities;Clinical Trials;college;Cultural Sensitivity;Databases;Decision Making;Department chair;design;Disparity;Doctor of Medicine;Doctor of Philosophy;Education;education research;Engineering;Ethics;experience;experimental analysis;Faculty;Fostering;Fright;Funding;Genetic;Goals;graduate school;hands on research;Health;Home;Individual;Institution;interest;Journals;Laboratories;lectures;Literature;matriculation;Measurement;Medicine;meetings;Mentors;Mentorship;Minority;minority student;minority trainee;minority undergraduate;Modeling;National Heart, Lung, and Blood Institute;National Institute of Neurological Disorders and Stroke;Neurosciences;New York;North Carolina;Oral;Outcome;outreach;Participant;Patient Care;Persons;Physicians;Physiology;Play;Policies;Postbaccalaureate;posters;Preparation;programs;Qualifying;Reading;Research;Research Methodology;Research Training;Resources;Rest;Risk;Role;role model;Science;Scientist;social;social media;Student Selections;Students;success;summer program;summer research;summer student;Surgeon;Talents;Training;Training Programs;undergraduate research experience;undergraduate student;Underrepresented Minority;Underrepresented Students;underserved community;United States National Institutes of Health;Universities;Vocational Guidance

PROJECT_TITLE: Training in Cardiovascular Sciences for Under Represented Students


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Complementary and Integrative Health;Hypertension;Nutrition;Physical Activity;Prevention;Rehabilitation

ORG_CITY: OKLAHOMA CITY

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PHR: PROJECT NARRATIVE  Combining a modified dietary approaches to stop hypertension (modDASH) eating plan with a home-based exercise program may be a new method that people with peripheral artery disease can do to optimally improve walking ability, quality of life, vascular function, and vascular inflammation. These improvements could also improve the long-term risks of having major cardiovascular events, as well as improve other health conditions such as obesity, diabetes, high cholesterol, and high blood pressure.

PI_NAMEs: GARDNER, ANDREW W (contact)

PROGRAM_OFFICER_NAME: NELLISSERY, MAGGIE JACOB

PROJECT_TERMS: Affect;Age Years;American;Ankle;Behavioral Paradigm;Biological Markers;Blood flow;Blood Vessels;C-reactive protein;cardiovascular risk factor;Cardiovascular system;Cholesterol;claudication;Clinical;clinically relevant;clinically significant;comparative effectiveness;Comparative Effectiveness Research;Consumption;cost;DASH diet;Data;Death Rate;Diabetes Mellitus;dietary;Dietary Intervention;Eating;efficacy testing;Event;Exercise;exercise intervention;exercise program;Exercise Therapy;fruits and vegetables;Functional disorder;Goals;Health;health related quality of life;Hemoglobin;High Prevalence;Home;human old age (65+);Hypertension;Impairment;improved;indexing;Inflammation;innovation;Institute of Medicine (U.S.);Intervention;Investigation;Knowledge;Leg;Lower Extremity;Measures;Mediating;Metabolic syndrome;Methods;Monitor;Muscle;novel;Obesity;Outcome;Outcome Measure;Pain in lower limb;patient oriented;Patients;Peripheral;Peripheral arterial disease;Persons;Physical Function;Physiological;primary outcome;programs;Quality of life;Randomized;Randomized, Controlled Trials;Recommendation;Risk;Risk Factors;secondary outcome;Severities;standard care;standard of care;Symptoms;systemic inflammatory response;Testing;Therapeutic Intervention;Time;treatment strategy;Unhealthy Diet;vascular inflammation;Walking;Work

PROJECT_TITLE: The Effects of Diet and Exercise Interventions in Peripheral Artery Disease

STUDY_SECTION: ASG

STUDY_SECTION_NAME: Aging Systems and Geriatrics Study Section[ASG]


NIH_SPENDING_CATS: Clinical Research;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: SAN FRANCISCO

ORG_DEPT: DERMATOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Our skin acts as a barrier to protect us from water loss and pathogen invasion, which is a process critically dependent on epithelial stem cells that constantly regenerate the epidermis and promote hair growth. Immune protection of stem cell niches in the skin is necessary to maintain barrier integrity; however, the mechanisms of immunoprotection that prevent autoimmune attack of cutaneous epithelial stem cells is unknown. Our research is focused on understanding these protective mechanisms in order to develop novel therapeutic strategies to treat skin conditions that are the result of immune-mediated destruction of epithelial stem cells.

PI_NAMEs: COHEN, JARISH NEWMAN (contact)

PROGRAM_OFFICER_NAME: UNDALE, ANITA H

PROJECT_TERMS: Advisory Committees;Affinity;Alopecia;analysis pipeline;Antigens;Autoimmune;autoimmune pathogenesis;Autoimmunity;autoreactive T cell;Biometry;California;career;career development;CD8-Positive T-Lymphocytes;Cell Communication;Cell Differentiation process;cell injury;Cells;Cellular biology;chemokine;Cicatrix;Clinical;clinical practice;clinical training;Communication;CTLA4 gene;Cutaneous;Cytoprotection;Data Aggregation;Dermatology;Dermatopathology;Development;Development Plans;Disease;Dissection;Doctor of Medicine;Doctor of Philosophy;draining lymph node;Epidermis;epithelial stem cell;epithelium regeneration;Exhibits;experience;experimental study;Formalin;Functional disorder;Funding;Gene Deletion;Goals;Growth;Hair;Hair follicle structure;Homeostasis;Human;human disease;IL2RA gene;Image Analysis;Imaging Techniques;Imaging technology;Immune;Immune mediated destruction;Immune response;Immune Tolerance;Immunological Models;Immunologics;Immunology;immunoregulation;Immunosuppression;in vivo Model;Incidence;Inflammation;Inflammatory;Injury;innovation;insight;instructor;Interleukin 2 Receptor;Interleukin-10;Interleukin-2;Invaded;Investigation;keratinocyte;Kinetics;Laboratories;lymph nodes;Lymphocyte;Mammals;Mediating;Mentors;Mentorship;Molecular;mouse model;multidisciplinary;multimodality;Multiplexed Ion Beam Imaging;Mus;Natural regeneration;Neoplastic skin;novel;novel therapeutic intervention;Organ;Paraffin Embedding;pathogen;Pathology;Pathway interactions;Patients;Pattern;Phase;Physicians;Play;Population;Postdoctoral Fellow;prevent;Process;Proliferating;Proteins;Regulatory Pathway;Regulatory T-Lymphocyte;Research;research and development;Research Personnel;Resources;restraint;Role;San Francisco;Scientist;secondary lymphoid organ;self-renewal;Services;single-cell RNA sequencing;Skin;skin disorder;Skin Physiology;stem cell biology;stem cell niche;stem cell proliferation;stem cells;T-Lymphocyte;Techniques;Testing;tissue repair;Tissues;Training;Training Programs;transcriptomics;Transforming Growth Factor beta;translational study;Universities;Water;Work

PROJECT_TITLE: Elucidating the Role of Regulatory T cells in Protecting Epithelial Stem Cell Niches

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

ORG_CITY: ITHACA

ORG_NAME: CORNELL UNIVERSITY

PHR: PROJECT NARRATIVE The MSTP at Cornell’s College of Veterinary Medicine (CVM) aims to develop a diverse pool of well-trained veterinary clinician-scientists with the disciplinary knowledge and skills that will uniquely prepare them for leadership roles in biomedical research to advance human health at the individual and population levels. By virtue of their broad knowledge of comparative disease and strong intellectual and lateral thinking abilities, veterinary clinician-scientists are uniquely suited to play key roles in advancing NIH goals in biomedical science and public health. Funding from the proposed MSTP will allow us to provide comprehensive programming and opportunities for Combined DVM-PhD Degree trainees, foster a spirit of diversity and inclusion, and nurture the research and professional skills necessary for our future leaders to tackle some of the most important biomedical problems we face in the 21st century.

PI_NAMEs: IVANEK MIOJEVIC, RENATA  (contact)

PROGRAM_OFFICER_NAME: NELSON, SHAKIRA M

PROJECT_TERMS: Doctor of Philosophy;Medical;Scientist;Training Programs;Universities

PROJECT_TITLE: Cornell University Combined DVM-PhD Medical Scientist Training Program (MSTP)

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - A[TWD-A]


NIH_SPENDING_CATS: Aging;Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease;Prevention

PHR: Narrative: Coronary artery disease is a major health problem in the world, leading to significant morbidity and mortality. In studies proposed here, Drs. Muzumdar and Dutta will evaluate the potential of a new peptide called Humanin to protect the heart following ischemia-reperfusion and prevent progression to heart failure in a clinically relevant mouse model of aging, and examine the mechanisms that mediate the cardioprotection. Humanin could be a potential new treatment option for treatment of acute myocardial infarction and prevention of progression to heart failure in the elderly.

PI_NAMEs: DUTTA, PARTHA ;MUZUMDAR, RADHIKA HIREN (contact)

PROGRAM_OFFICER_NAME: GAO, HONGWEI

PROJECT_TERMS: Acute;Acute myocardial infarction;acyl-CoA oxidase;Adolescent;Affect;Age;age related decline;Age Years;age-related disease;aged;Aging;Alzheimer's Disease;Apoptosis;Apoptotic;Applications Grants;Area;Atherosclerosis;Attenuated;Biological Markers;Cardiac;Cardiac Myocytes;cardioprotection;Cardiovascular Diseases;cardiovascular risk factor;catalase;Cause of Death;Cell Death;Cerebral Ischemia;Cessation of life;Chronic;Circulation;Clinical;clinically relevant;Complement;Coronary Arteriosclerosis;coronary fibrosis;Coronary heart disease;Cytoprotection;Data;Development;Dose;Elderly;Enzymes;Exhibits;experimental study;Family;Family suidae;fatty acid oxidation;Fatty Acids;Frequencies;Gender;Genetic;Grant;Health;Heart;Heart failure;heart function;heart preservation;Heart Transplantation;Human;human subject;humanin;Hypoxia;Impaired cognition;improved;in vivo;Incidence;Infarction;Injections;Injury;insight;Ischemia;ischemic injury;Knock-out;Knowledge;Magnetic Resonance Imaging;male;Measures;Mediating;member;Metabolic;Metabolism;middle age;Miniature Swine;Mitochondria;Modality;Modeling;Morbidity - disease rate;mortality;mortality risk;mouse model;Mus;Myocardial;myocardial damage;Myocardial Infarction;myocardial injury;Myocardial Ischemia;Myocardial Reperfusion Injury;Myocardial tissue;Myocardium;neuroprotection;Non-Insulin-Dependent Diabetes Mellitus;novel;old mice;Outcome;Oxidative Stress;Patients;Peptides;percutaneous coronary intervention;peroxisome;Phase;Play;porcine model;preclinical study;prevent;Prevention;protective factors;Publishing;Reperfusion Injury;Reperfusion Therapy;Risk;Risk Factors;Rodent;Role;Stroke;Testing;Therapeutic;Therapeutic Effect;Time;Tissue Harvesting;Tissues;Viral

PROJECT_TITLE: Cardioprotective role of Humanin in aging


NIH_SPENDING_CATS: Aging;Clinical Research;Lung;Pulmonary Fibrosis;Rare Diseases

ORG_CITY: BURLINGTON

ORG_NAME: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE

ORG_STATE: VT

PHR: PROJECT NARRATIVE The progressive nature of pulmonary fibrosis (IPF) progression represents a major hurdle in designing effective therapies. Our recent studies have shown that in IPF lungs, a unique type of protein oxidation occurs which involves attachment of glutathione to proteins (termed glutathionylation). We also showed that treatment of fibrotic mouse lung with the protein oxidation repair enzyme, glutaredoxin, reversed existing pulmonary fibrosis. Most recently we discovered that collagen, which makes up scar tissue, can be glutathionylated and this not only makes it resistant to normal degradation processes but also activates myofibroblasts, which are collagen- producing cells, thereby creating a potentially fibrosis-progressive scenario. In this project we examine how collagen glutathionylation occurs and how it activates myofibroblasts. We will study whether this process is disturbed in aged lung and if this is reversible by glutaredoxin. Given that we have developed pure glutaredoxin preparations, completion of the studies may have potential impact for the treatment of persistent fibrosis in aged lungs.

PI_NAMEs: JANSSEN-HEININGER, YVONNE M. W. (contact)

PROJECT_TITLE: Collagen Oxidation, Myofibroblast Activation and Age-Associated Pulmonary Fibrosis

STUDY_SECTION: LIRR

STUDY_SECTION_NAME: Lung Injury, Repair, and Remodeling Study Section[LIRR]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Pediatric

ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Project Narrative Exposomics is a new field that aims to comprehensively study all health relevant environment and is a key tool to understand the developmental origins of health and disease. This research training program provides cutting edge post-doctoral research fellowship training in pediatric exposomics to prepare these early career researchers to become future academic leaders in the emerging field of environmental pediatrics.

PI_NAMEs: CARROLL, KECIA NICOLE;WRIGHT, ROBERT O (contact)

PROGRAM_OFFICER_NAME: RUSSO, DENISE

PROJECT_TITLE: Research Training Program in Pediatric Exposomics


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Clinical Research;Hematology;Kidney Disease;Patient Safety;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn

ORG_CITY: DURHAM

ORG_NAME: BAEBIES, INC.

ORG_STATE: NC

PHR: PROJECT NARRATIVE Acute kidney injury (AKI) is characterized by a sudden decrease in the ability of the kidneys to adequately maintain electrolyte, acid-base, and fluid balance. Continuous renal replacement therapy (CRRT) has recently emerged as the preferred dialysis modality for critically ill children and is becoming increasingly common for newborns and small children (under 10 kg) with AKI and congenital kidney failure. While frequent monitoring of anticoagulant therapy, kidney function, and electrolyte composition is necessary during the course of CRRT, existing laboratory tests require large blood volumes, contributing to iatrogenic anemia and subsequent blood transfusions. To meet the critical unmet need for rapid, low volume blood tests for CRRT monitoring in newborns and children, we will develop a panel of four assays on our near-patient digital microfluidic platform to provide comprehensive profiling of anticoagulation dosing, kidney function, and phosphorus balance.

PI_NAMEs: PAMULA, VAMSEE K. (contact)

PROGRAM_OFFICER_NAME: WARREN, RONALD Q

PROJECT_TERMS: Acids;Activated Partial Thromboplastin Time measurement;Acute;acute care;Acute Renal Failure with Renal Papillary Necrosis;Admission activity;Adult;Alabama;American;Anemia;Anticoagulant therapy;Anticoagulation;assay development;Award;base;Biochemical;Biological Assay;Blood;Blood Tests;Blood Transfusion;Blood Urea Nitrogen;Blood Volume;Cardiac Surgery procedures;Chemistry;Child;Childhood;Clinical;Clinical Chemistry;comorbidity;Complex;Consumption;Critical Illness;Critically ill children;critically ill newborn;Custom;Death Rate;design;Development;Device or Instrument Development;Diagnostic;Dialysis procedure;digital;Dose;Drops;Electrolytes;Equilibrium;Erythrocyte Transfusion;Excision;Extremely Low Birth Weight Infant;Factor Xa;Fluid Balance;Fluid overload;Funding;Goals;Guidelines;Hematology;Hemodialysis;Hemorrhage;Heparin;Heparinoids;Hospitalization;Human Resources;Iatrogenesis;Individual;Infant;Injury to Kidney;innovation;insight;instrument;Intensive Care Units;Journals;Kidney;Kidney Failure;Laboratories;Lead;Left;Legal patent;Length;life span;Liquid substance;Manuscripts;Marketing;Measures;Metabolic;Methods;microfluidic technology;Microfluidics;Modality;Monitor;Monitoring for Recurrence;Neonatal Intensive Care Units;neonate;Nephrology;Newborn Infant;novel strategies;Outcome;Patient Monitoring;Patients;Pediatric Hospitals;pediatric patients;Performance;Phase;Phosphorus;Plasma;portability;Potassium;Premature Infant;Procedures;professor;Publications;Publishing;Reaction;Recurrence;Renal function;Renal Replacement Therapy;Reporting;research clinical testing;risk minimization;Sampling;Site;Small Business Innovation Research Grant;System;Technology;Testing;Time;Toxin;Transfusion;Ultrafiltration;Universities;Urea;Uremia;usability;Validation;Whole Blood;Work

PROJECT_TITLE: A Low Blood Volume Platform for Recurrent Anticoagulation and Kidney Monitoring during Continuous Renal Replacement Therapy in Critically Ill Children

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-VH-C(10)B]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Cervical Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Machine Learning and Artificial Intelligence;Prevention;Sexually Transmitted Infections;Women's Health Research

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: PROJECT NARRATIVE Invasive cervical cancer disproportionately burdens women living with HIV (WLWH) and can be prevented with appropriate screening coupled with effective treatment of cervical precancerous lesions. We propose to establish a CASCADE Network UG1 Research Base at the University of North Carolina to develop, implement, and analyze hybrid effectiveness-implementation trials of innovative, yet pragmatic, strategies to reduce cervical cancer among WLWH. If strategies are found to be clinically effective, acceptable, and cost-effective, CASCADE Trial findings have potential to inform clinical practice guidelines to ultimately reduce cancer disparities among WLWH in the United States and low-and-middle income countries.

PI_NAMEs: CHINULA, LAMECK ;HUDGENS, MICHAEL G;SMITH, JENNIFER SUSAN (contact)

PROGRAM_OFFICER_NAME: FRECH, MARIA SILVINA

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Adherence;Adjuvant;Advisory Committees;Area;automated visual evaluation;Award;base;Cancer Control;cancer health disparity;career;Cervical;cervical cancer prevention;Clinical;Clinical effectiveness;Clinical Practice Guideline;Clinical Research;clinical research site;Clinical Skills;clinical training;Clinical Trials;Cluster randomized trial;Collaborations;Communicable Diseases;Comprehensive Cancer Center;cost effective;cost effectiveness;Cost Effectiveness Analysis;Coupled;Data;design;Disparate;disparities in women;Dissemination and Implementation;Educational workshop;effective therapy;effectiveness evaluation;effectiveness research;effectiveness/implementation trial;Ensure;Epidemiologist;evidence base;Evidence based intervention;experience;Funding;Gills;global health;Goals;Health Services Accessibility;high risk;HIV;HPV positive;HPV screening;Human Papillomavirus;hybrid type 1 trial;implementation outcomes;implementation science;improved;Information Dissemination;innovation;Institution;International;Intervention;Intravaginal Administration;Leadership;Lesion;low and middle-income countries;Malawi;Malignant neoplasm of cervix uteri;Mentorship;Methodology;multidisciplinary;North Carolina;novel;Outcome;Pathology;Patient advocacy;Performance;Postdoctoral Fellow;premalignant;prevent;Prevention;Procedures;Process;Protocols documentation;Public Health;Randomized;Recurrence;Regulatory Affairs;Research;Research Activity;Research Design;Research Personnel;Research Training;Schools;screening;screening guidelines;Self Administration;skills;skills training;standard of care;Statistical Data Interpretation;Structure;Testing;Training;training opportunity;Training Programs;Translational Research;treatment guidelines;treatment strategy;Triage;trial comparing;United States;Universities;uptake;Woman;World Health Organization

PROJECT_TITLE: UNC CASCADE Network Research Base


NIH_SPENDING_CATS: Autoimmune Disease;Complementary and Integrative Health;Dietary Supplements;Digestive Diseases;Inflammatory Bowel Disease;Lupus;Microbiome;Nutrition;Pediatric;Prevention

ORG_CITY: CHARLESTON

ORG_DEPT: PHARMACOLOGY

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: PROJECT NARRATIVE Fermentation of non-digestible, complex dietary polysaccharides by distal gut microbes can enhance and maintain beneficial microbes in the distal gut and generate immune regulatory metabolites. Therefore, identification and functional characterization of microbial metabolites from complex dietary polysaccharide degradation could lead to the development of precision -nutrition and -medicine approaches to prevent and treat immune-mediated disorders. Our proposed studies are expected to identify novel microbial metabolites of candidate complex dietary polysaccharide degradation and functionally characterize them for the ability to enhance gut and systemic immune regulation.

PI_NAMEs: VASU, CHENTHAMARAKSHAN  (contact)

PROGRAM_OFFICER_NAME: MARUVADA, PADMA

PROJECT_TERMS: Administrative Supplement;Adolescent;Age;Algae;Anti-Inflammatory Agents;Autoimmune;Autoimmune Diseases;Autoimmunity;B-Lymphocytes;beneficial microorganism;beta-Glucans;Biological Assay;Carbohydrates;Cell Physiology;Cells;Clinical;Colitis;comparison control;Complex;Consult;Consumption;data sharing;Dendritic Cells;Development;Diet;Dietary Polysaccharide;dietary supplements;Disease;Disease Outcome;Disease Progression;Distal;dysbiosis;Energy-Generating Resources;epithelial stem cell;Event;fecal microbiota;Fermentation;Functional disorder;gastrointestinal epithelium;Genetic Predisposition to Disease;Glucans;Gnotobiotic;Goals;gut dysbiosis;gut inflammation;gut microbes;gut microbiota;Gut Mucosa;Human;Immune;immune function;immunoregulation;In Vitro;in vivo;Inflammatory;Inflammatory Bowel Diseases;insulin dependent diabetes mellitus onset;Insulin-Dependent Diabetes Mellitus;intestinal epithelium;Intestines;knowledgebase;Link;Mediating;Medicine;meetings;Metabolic;Metabolic Diseases;Methods;Microbe;microbial;microbial signature;microbiota;microbiota composition;Modeling;Mucins;Mus;National Institute of Allergy and Infectious Disease;National Institute of Diabetes and Digestive and Kidney Diseases;Nature;novel;Nutraceutical;Onset of illness;Oral;Outcome;Pathogenesis;Patients;Persons;prebiotics;precision nutrition;prevent;Process;Production;Property;Reporting;response;Series;Severities;Shapes;signature molecule;small molecule;Structure;symposium;Systemic Lupus Erythematosus;T-Lymphocyte;Therapeutic;Therapeutic Effect;United States National Institutes of Health;Volatile Fatty Acids;Work;Yeasts

PROJECT_TITLE: Identification and Functional Characterization of Bioactive Microbial Metabolites of Beta-Glucan Degradation

STUDY_SECTION: XNDA

STUDY_SECTION_NAME: Xenobiotic and Nutrient Disposition and Action Study Section[XNDA]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Neurosciences;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: PROJECT NARRATIVE Adult neural stem cells (NSCs) are a population of cells in the adult brain that can self-renew and give rise to a variety of cell types, including neurons. NSCs are of tremendous interest for both their potential role in neural development and disease and because they may be harnessed in various ways to treat neurodegenerative disease (e.g., Alzheimer’s, Parkinson’s, and Lou Gehrig’s Diseases). The goal of this proposal is to understand mechanisms through which biomechanical inputs from the cellular microenvironment influence NSC neurogenesis, which we expect will significantly add to our understanding of NSC biology and help inform the design of tissue engineering and regenerative medicine strategies to treat disease.

PI_NAMEs: KUMAR, SANJAY ;SCHAFFER, DAVID V (contact)

PROGRAM_OFFICER_NAME: LAVAUTE, TIMOTHY M

PROJECT_TERMS: 3-Dimensional;Acceleration;Actins;Address;Adult;Alzheimer's Disease;AMOT gene;Amyotrophic Lateral Sclerosis;Astrocytes;beta catenin;Biochemical;Biocompatible Materials;Biological;biomechanical test;Biomechanics;Biophysics;Brain;Cell Lineage;cell type;Cells;cellular targeting;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;crosslink;Cues;Cytoskeleton;Data;Decision Making;dentate gyrus;Dependence;design;Development;Dimensions;Disease;DNA;Elasticity;Engineering;Event;Extracellular Matrix;Foundations;Genetic Transcription;genome editing;Goals;Guanosine Triphosphate Phosphohydrolases;Hippocampus;Hour;Hydrogels;in vivo;innovation;insight;interest;Learning;Life;loss of function;Maps;Measurement;mechanical signal;Mechanics;mechanotransduction;Mediating;Memory;Molecular;Myosin ATPase;nerve stem cell;Nervous System Disorder;neural;Neurodegenerative Disorders;neurodevelopment;neurogenesis;neuromechanism;Neurons;novel;Oligodendroglia;Oligonucleotides;optogenetics;Parkinson Disease;Physiologic pulse;Play;polyacrylamide hydrogels;Population;Process;Productivity;Property;Rattus;Reagent;Regenerative Medicine;Regulation;Relaxation;repaired;Role;screening;self-renewal;Signal Transduction;stem cell biology;stem cell fate;stem cell self renewal;stem cells;Stress;Structure;System;Technology;Testing;Time;time use;Tissue Engineering;Tissues;tool;transcription factor;transcriptome sequencing;two-dimensional;Variant;viral gene delivery;viscoelasticity;Viscosity;Work

PROJECT_TITLE: Mechanisms of Neural Stem Cell Mechanoregulation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-J(02)]


NIH_SPENDING_CATS: Neurosciences

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative This project will elucidate mechanisms that regulate neuropeptide packaging and release from terminals undergoing plasticity and the soma, a noncanonical site of release. These mechanisms are essential to understanding how neuropeptides control rhythmic behaviors (e.g., circadian rhythms and sleep), pain, appetite, and mood.

PI_NAMEs: LEVITAN, EDWIN S (contact)

PROGRAM_OFFICER_NAME: MATOS GALICIA, HEIDI YANICE

PROJECT_TERMS: Action Potentials;Axon;Axonal Transport;Behavior;Behavior Control;Biochemical;Brain;Cellular biology;circadian;circadian pacemaker;Circadian Rhythms;connectome;Coupled;Dense Core Vesicle;Desire for food;detection method;Development;Diglycerides;Disabling;Discrimination;Drosophila genus;Equilibrium;Exocytosis;experimental study;Fluorescence;G-Protein-Coupled Receptors;Genetic;Hot Spot;Image;in vivo imaging;Individual;insight;Kinetics;Knowledge;Life;Link;Location;Measures;Mediating;Moods;Morphology;Motor Activity;Motor Neurons;Nervous System;Neurodegenerative Disorders;neuronal cell body;Neurons;Neuropeptides;neurotrophic factor;novel strategies;operation;Optical Methods;Optics;Pain;Pathway interactions;Peptides;Periodicity;Phospholipase C;presynaptic;Process;Property;Protein Isoforms;Protein Tyrosine Kinase;Protein Tyrosine Phosphatase;Proteins;receptor;Regulation;Research;Resources;response;Rest;Role;Running;sensor;Signal Induction;Signal Transduction;Site;Sleep;SNAP receptor;Synapses;synaptic function;Testing;Time;tool;transmission process;Work

PROJECT_TITLE: Compartmental, rhythmic and plastic neuropeptide release

STUDY_SECTION: NDPR

STUDY_SECTION_NAME: Neurodifferentiation, Plasticity, Regeneration and Rhythmicity Study Section[NDPR]


NIH_SPENDING_CATS: Biotechnology;Gene Therapy;Genetics;HIV/AIDS;Immunotherapy;Infectious Diseases;Mental Health;Neurosciences

ORG_DEPT: VETERINARY SCIENCES

PHR: An HIV cure has proven elusive given the persistence of HIV in tissue sanctuaries in people with HIV on suppressive anti-HIV drugs. A better understanding of the source of HIV rebound when anti-HIV drugs are halted is needed in order to guide effective HIV cure strategies. Our long-term goals are 1) understanding HIV and SIV reservoirs in both CD4 T cells and myeloid cells across the central nervous system (CNS) and lymphoid tissues, 2) developing a cellular immunotherapy using virus-specific chimeric antigen receptor (CAR) T cells that target tissue reservoirs of HIV in the CNS and lymphoid tissues that durably suppress HIV replication.

PI_NAMEs: BYRAREDDY, SIDDAPPA N;NDHLOVU, LISHOMWA C;SKINNER, PAMELA J (contact)

PROGRAM_OFFICER_NAME: RAO, VASUDEV RAMACHANDRA

PROJECT_TERMS: animal model development;Anti-HIV Agents;antiretroviral therapy;Autologous;B-Lymphocytes;Basal Ganglia;Binding;Biological Assay;Biological Models;BLR1 gene;Brain;Brain region;Brain Stem;CAR T cell therapy;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;cell type;Cells;Cellular immunotherapy;cellular targeting;Central Nervous System;Cerebellum;chimeric antigen receptor;chimeric antigen receptor T cells;Chronic;Clinical Research;CXCL13 gene;Data;Disease remission;Engineering;Goals;HIV;HIV Infections;Human;Immune;Immunotherapeutic agent;Immunotherapy;In Vitro;Infection;Interruption;Intervention;Location;Lymphoid;Lymphoid Follicle;Lymphoid Tissue;Macaca mulatta;Macrophage;Meninges;Methods;Microglia;Modeling;Myelogenous;Myeloid Cells;next generation;nonhuman primate;Penetration;Peripheral;Persons;Plasma;Population;Productivity;Recrudescences;Research;Rhesus;Site;SIV;Source;Spinal Cord;T cell therapy;T-Lymphocyte;targeted treatment;Tissues;Viral;Viral Load result;viral rebound;Viral reservoir;Virus

PROJECT_TITLE: Targeting CNS reservoirs with CAR/CXCR5 T cells for the long-term remission of HIV