NIH_SPENDING_CATS: Clinical Research;Data Science

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PI_NAMEs: MEAGHER, EMMA ANNE (contact)

PROGRAM_OFFICER_NAME: CURE, PABLO

PROJECT_TERMS: Academia;Address;Advocacy;Appointment;Awareness;Basic Science;biomedical informatics;Biotechnology;Budgets;Businesses;Caliber;career;Career Choice;Clinical;clinical care;clinical development;clinical practice;Clinical Research;Clinical Sciences;clinical training;clinical translation;cohort;Communities;Competence;cost efficient;Coupled;Data;Data Science;Dedications;Degree program;Dental;design;Development;Development Plans;Discipline;Discipline of Nursing;diversity and inclusion;Doctor of Philosophy;doctoral student;Education;Educational Background;Educational Curriculum;Educational workshop;Elements;Engineering;Enrollment;Ensure;expectation;experience;Faculty;flexibility;Foundations;Funding;Goals;Government;Grant;Health Policy;Health Priorities;Healthcare;Hospital Design;implementation science;improved;Industry;innovation;innovative technologies;Institution;Instruction;interest;K-Series Research Career Programs;Knowledge;Leadership;Learning;Marketing;Master of Science;Medical;Medicine;Mentors;Methodology;Mission;National Research Service Awards;next generation;Patient Care;Patients;Peer Review;Pennsylvania;Pharmacists;Pharmacy facility;Physicians;Politics;post-doctoral training;Postdoctoral Fellow;pre-doctoral;Program Development;programs;Psychologist;Publications;Qualifying;recruit;Research;Research Personnel;Research Project Grants;Resources;Review Literature;Science;Scientist;skill acquisition;skills;skills training;Sociology;Solid;square foot;Structure;Students;success;Time;TNFSF15 gene;Training;Training and Education;training opportunity;Training Programs;Translating;translational medicine;Translational Research;translational therapeutics;Translations;United States National Institutes of Health;Universities;Workforce Development

PROJECT_TITLE: NRSA Training Core


ADMINISTERING_IC: EY

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Congenital Structural Anomalies;Eye Disease and Disorders of Vision;Genetics;Human Genome;Neurodegenerative;Neurosciences;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human

ORG_CITY: DAVIS

ORG_COUNTRY: UNITED STATES

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

ORG_STATE: CA

PI_NAMEs: BROWN, NADEAN L (contact)

PROGRAM_OFFICER_NAME: SONG, HONGMAN

PROJECT_TERMS: Address;Adopted;Adult;Alleles;Animal Model;Aniridia;Anophthalmos;astrocyte progenitor;Astrocytes;ATAC-seq;Automobile Driving;Bacterial Artificial Chromosomes;Bioinformatics;Blindness;Brain;Cell division;Cell Lineage;cell type;Cells;Characteristics;Childhood;ChIP-seq;Choroid;Chromatin;Chromatin Structure;Coloboma;complement C2a;Complex;conditional mutant;Confocal Microscopy;Cre driver;Data;Databases;Deformity;Development;Disease;DNA;Embryo;embryo tissue;Embryology;Enhancers;Epigenetic Process;Event;experimental study;Eye;Eye Development;Eye diseases;Failure;Freezing;Gene Expression;Gene Expression Profile;Genes;Genetic;Glaucoma;Goals;Heterozygote;Histology;Homeostasis;Human;hybrid gene;Immunohistochemistry;In Situ Hybridization;in vivo;inner ear development;insight;interstitial cell;Kidney;Knock-in;Knowledge;LoxP-flanked allele;Maintenance;malformation;Microphthalmos;Mitotic;Modeling;Molecular;Morphogenesis;mouse development;mouse genetics;mouse model;mRNA Expression;Mus;mutant;mutant mouse model;Mutation;Nephrons;Nerve;neural;Neural Retina;Neuroglia;Neurons;next generation sequencing;novel;Null Lymphocytes;optic cup;Optic Disk;Optic Nerve;optic nerve disorder;Optic Neuritis;optic stalk;Optic vesicle;optical disc;Optics;Organ;Organism;Pathway interactions;Pattern;Peptide Initiation Factors;Phenotype;Pigment Epithelium;postnatal;progenitor;programs;Recommendation;recruit;Research;Retina;Retinal Diseases;retinal progenitor cell;Role;Side;Signal Transduction;single-cell RNA sequencing;stem cell differentiation;stem cell fate;stem cell genes;Technology;Testing;Tissues;tool;transcription factor;Transgenic Mice;Transgenic Organisms;Untranslated RNA;Visual Fields;Visual impairment;Visual System;Xenopus

PROJECT_TITLE: Optic Stalk-Disc Development and Differentiation

STUDY_SECTION: BDE

STUDY_SECTION_NAME: Biology and Development of the Eye Study Section[BDE]


ADMINISTERING_IC: AR

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Clinical Research;Eye Disease and Disorders of Vision;Genetics;Rare Diseases

ORG_CITY: SAINT LOUIS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Spondyloarthritis is a complex disease with a multitude of manifestations, spanning the joint, skin, gut, and eye. Given the inherent immune restrictions of the eye, we theorize that sampling the human eye during periods of ocular inflammation will enrich for pathogenic immune cells in spondyloarthritis, specifically T cells. We propose to use single-cell RNA sequencing to identify putative pathogenic T cells in the human eye and to assess whether dysregulation of these T cells track with disease activity in other anatomic sites.

PI_NAMEs: PALEY, MICHAEL ALEXANDER (contact)

PROGRAM_OFFICER_NAME: MAO, SU-YAU

PROJECT_TERMS: Address;Anatomy;Ankylosing spondylitis;anterior chamber;Anterior uveitis;Antigens;Area;biobank;Bioinformatics;Blindness;Blood;Blood donor;Blood specimen;career;Cataract;CD8-Positive T-Lymphocytes;CD8B1 gene;cell type;Cells;Circulation;Clinical;cohort;Committee Members;Complement;Complex;cytokine;Cytometry;Data;Development;Dimensions;Discrimination;Disease;Disease remission;Distant;Exhibits;experience;Eye;eye chamber;Eye diseases;Flare;Flow Cytometry;Frequencies;Future;Gene Expression Profile;Genetic Transcription;Glaucoma;Goals;high risk population;HLA Antigens;Homing;Human;IL17 gene;Immune;Immunologics;In Vitro;Individual;Inflammation;Inflammatory;insight;joint inflammation;Joints;K-Series Research Career Programs;KLRB1 gene;Learning;lifetime risk;Mentors;Methods;Mucous Membrane;multidisciplinary;new therapeutic target;novel;Onset of illness;Organ;Paracentesis;Pathogenesis;Pathogenicity;Pathology;Patients;peripheral blood;Phenotype;Play;Population;Process;Productivity;programmed cell death protein 1;programs;Property;protein expression;Psoriasis;receptor;receptor expression;Receptor Signaling;Research;Research Personnel;Rheumatism;Rheumatology;Riboflavin;Role;Sampling;Scientist;single-cell RNA sequencing;skills;Skin;Sorting;Specificity;Spondylarthritis;Stimulus;Surface;systemic autoimmune disease;Systemic disease;T cell receptor repertoire sequencing;T-Cell Receptor;T-Cell Receptor Genes;T-Lymphocyte;theories;Tissues;trafficking;Training;translational scientist;Uveitis;Viral Antigens

PROJECT_TITLE: Identification of Pathogenic T cells in Axial Spondyloarthritis

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Hepatitis;Liver Disease;Orphan Drug;Rare Diseases;Substance Misuse

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Alcoholic hepatitis is a life-threatening complication of alcoholic liver disease, and it is increasing in frequency. It is widely believed that alcoholic hepatitis results largely from damage to hepatocytes, but recent work suggests that alterations in bile duct cells (cholangiocytes) also contribute to the development of this disease. This project will determine whether and how white blood cells affect cholangiocytes in alcoholic hepatitis, which may lead to identification of new targets for therapy.

PI_NAMEs: NATHANSON, MICHAEL H (contact)

PROGRAM_OFFICER_NAME: PERRUCCIO, ELIZABETH M

PROJECT_TERMS: Affect;Alcoholic Hepatitis;Alcoholic Liver Diseases;Animal Model;Apoptosis;Attenuated;Bicarbonates;bile duct;Bile Duct Epithelium;Bile fluid;Biliary;Biliary Atresia;Calcium;Calcium Channel;cell type;cholangiocyte;Cholestasis;Clinical;Complication;Data;Defect;Development;Disease;Ductal Epithelial Cell;Etiology;Frequencies;Functional disorder;Hepatic lobule;Hepatocellular Damage;hepatocellular injury;Hepatocyte;Human;Impairment;improved;inorganic phosphate;Inositol;Leukocytes;Life;Liquid substance;liver biopsy;Liver diseases;liver injury;Mediating;Molecular;mortality;neutrophil;Neutrophil Infiltration;new therapeutic target;novel therapeutics;Obstruction;Organoids;Pathogenesis;Pathogenicity;Pathway interactions;Patients;Play;Primary biliary cirrhosis;primary sclerosing cholangitis;Process;Prognosis;Protein Isoforms;Publications;receptor;receptor expression;Role;Serum;Signal Pathway;Steroids;targeted treatment;Testing;therapeutic target;Transaminases;Work

PROJECT_TITLE: Interactions between neutrophils and cholangiocytes in alcoholic hepatitis

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Mental Health;Neurodegenerative;Neurosciences;Prevention;Sleep Research

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: This proposed study will evaluate the impact of an Internet-delivered insomnia intervention and the extent to which it contributes to cognitive health in older adults with cognitive impairment. The proposed research is relevant to public health because of the potential preservation of cognition in a growing, at-risk population using a non-pharmacologic and accessible intervention.

PI_NAMEs: MATTOS, MEGHAN K (contact)

PROGRAM_OFFICER_NAME: HAAKENSON, CHELSEA MARIE

PROJECT_TERMS: acceptability and feasibility;Adult;adverse outcome;Advertisements;Affect;Aging;Alzheimer's Disease;arm;Attention;career;Chronic Disease;Chronic Insomnia;Clinical;Clinical Trials;Clinical Trials Design;Cognition;Cognitive;cognitive performance;Cognitive Therapy;Collection;comparison intervention;Coupled;dementia care;Development;digital health;digital treatment;Disease;efficacy evaluation;efficacy testing;executive function;experience;falls;Fatigue;Feeling;follow-up;Fortification;Funding;Future;Geriatric Nursing;Gerontology;Goals;Health;health assessment;Hour;Impaired cognition;Impairment;improved;improvement on sleep;Individual;innovation;instrument;International;Internet;internet delivery;Intervention;intervention effect;K-Series Research Career Programs;Leadership;Left;Measures;Memory;Mentorship;Methods;mild cognitive impairment;Moods;Nervous System Disorder;Neuropsychology;Nurses;older adult;Outcome;Participant;Patient Care;Patient Education;Patient Recruitments;Patients;Personal Satisfaction;Persons;pharmacologic;Population;Populations at Risk;Positioning Attribute;post intervention;preservation;prevent;programs;Provider;Psychomotor Performance;Public Health;Quality of life;randomized trial;Randomized, Controlled Trials;Recommendation;Recording of previous events;recruit;Reproducibility;Research;Research Personnel;Research Project Grants;Resources;Role;Science;Scientist;Severities;Sleep;Sleep Disorders;sleep onset;Sleeplessness;social networking website;Speed;success;Symptoms;Technology;Time;Training;Translating;Travel;trial design;Universities;Virginia;Work

PROJECT_TITLE: Internet-based insomnia intervention to prevent cognitive decline in older adults with mild cognitive impairment


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Bioengineering

ORG_DEPT: OTOLARYNGOLOGY

PI_NAMEs: DANIERO, JAMES J. (contact);GRIFFIN, DONALD RICHIERI

PROGRAM_OFFICER_NAME: KOPF, LISA MARIE

PROJECT_TERMS: Accidents;Acute;Address;Adverse event;Biocompatible Materials;Biological;Biological Assay;Biomechanics;Cadaver;Cells;Characteristics;Clinical;Clinical Research;Clinical Trials;common treatment;Communication impairment;Complex;Cytometry;cytotoxicity;Deglutition;design;ergonomics;Evaluation;Extracellular Matrix;Fingerprint;first-in-human;Functional disorder;Gel;genotoxicity;Goals;Good Manufacturing Process;high dimensionality;histiocyte;Homeostasis;Human;Hydrogels;Hypersensitivity;Immobilization;Implant;implantation;improved;In Situ;in vivo;indexing;Inflammation;Injectable;Injections;Intramuscular;Laryngeal Diseases;Larynx;mechanical properties;Mechanics;Methods;Modeling;Modulus;Molecular;nanoindentation;Nanoporous;novel;Operative Surgical Procedures;Paralysed;particle;Phase;Pilot Projects;Pliability;Porosity;Positioning Attribute;pre-clinical;Pre-Clinical Model;Property;Radiation;Raman Spectrum Analysis;research clinical testing;response;Retrieval;Safety;scaffold;Secure;standard of care;success;systemic toxicity;technology development;Testing;Time;Tissues;Titrations;Toxic effect;Toxicology;Translating;translational potential;Trauma;vocal cord;Voice

PROJECT_TITLE: Translating a biostimulatory implant for the long-term treatment of glottic insufficiency


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Kidney Disease

ORG_CITY: STANFORD

ORG_DEPT: BIOPHYSICS

ORG_NAME: STANFORD UNIVERSITY

PHR: PUBLIC HEALTH RELEVANCE: CLC channels are compelling targets for drug development, yet CLC pharmacology is undeveloped. The CLC-Ka inhibitors developed in this project will advance biomedicine by providing novel tools to investigate the function of CLC-Ka in the kidney and to advance new kidney therapies. The research results will provide a roadmap for further developing CLC pharmacology to treat kidney, muscle, bone, and neurological disease.

PI_NAMEs: MADUKE, MERRITT C (contact)

PROGRAM_OFFICER_NAME: KETCHUM, CHRISTIAN J

PROJECT_TERMS: absorption;Acceleration;Anions;BCL2L11 gene;benzimidazole;Binding;Binding Sites;Biological Assay;Bone Diseases;Cattle;Cerebrum;Cessation of life;Chloride Channels;Chlorides;Cirrhosis;Clinical;Coma;Complex;Cryoelectron Microscopy;Data;design;Development;Disease;Docking;drug candidate;drug development;drug discovery;Drug Kinetics;drug metabolism;Drug Targeting;Electrophysiology (science);Epithelial Cells;Excretory function;falls;Family;FDA approved;Formulation;Goals;Headache;Heart failure;Homologous Gene;Human;Hydration status;Hypertension;Hyponatremia;improved;In Vitro;in vitro testing;in vivo;in vivo evaluation;inhibitor;insight;Ion Channel;Kidney;Kidney Diseases;kidney interstitial tissue;Lethargies;Ligands;Limb structure;liver injury;Location;Malaise;Membrane Proteins;Metabolism;meter;microscopic imaging;Modification;Molecular;Molecular Structure;Mus;mutant;Myopathy;Nephrons;Nervous System Disorder;Neurologic;next generation;novel;Oral;Organism;Output;Pathologic;Patients;Pharmaceutical Chemistry;Pharmacology;Physiological;Play;Positioning Attribute;Potassium Channel;Process;Property;Proteins;public health relevance;receptor;Receptor Inhibition;Research;Resolution;Risk;Role;Safety;scaffold;screening;Site-Directed Mutagenesis;Sodium Chloride;solute;Structure;success;Testing;Thick;Thinness;tolvaptan;tool;Toxic effect;Urine;Vasopressins;Water;Work

PROJECT_TITLE: Structure-based strategy for developing inhibitors of the kidney chloride channel CLC-Ka

STUDY_SECTION: KUFD

STUDY_SECTION_NAME: Kidney and Urological Systems Function and Dysfunction Study Section[KUFD]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_CITY: MORGANTOWN

ORG_DEPT: NEUROSCIENCES

ORG_NAME: WEST VIRGINIA UNIVERSITY

ORG_STATE: WV

PHR: PROJECT NARRATIVE This project aims elucidate the role neutrophilsnplay in the homeostatic regulation of the CNS. Specifically, determining how neutrophils modulate neuronal function and ultimately an organism behavioral output, will greatly inform our understanding of their role in injury and neurodegeneration. The results of this project will not only define a new role for neutrophils, it will also define the meninges as a non-medullary source of these cells.

PI_NAMEs: COULIBALY, AMINATA PORHY (contact)

PROGRAM_OFFICER_NAME: DALEY, WILLIAM PATRICK

PROJECT_TERMS: Affect;Antibodies;Area;B-Lymphocytes;Behavior;Behavioral;Bioinformatics;Bone Marrow;Bone Marrow Cytometry;Brain;career;Cell Maturation;Cells;Cerebrospinal Fluid;Chimera organism;cisterna magna;Cognition;cognitive function;Color;Confocal Microscopy;Data;Electrophysiology (science);experimental study;Goals;Grant;Granulocyte Colony-Stimulating Factor;Homeostasis;Immune system;Immunohistochemistry;immunoregulation;Injury;innate immune pathways;Innate Immune System;intraperitoneal;Knowledge;Learning;Location;Macrophage;Mammals;Mediating;Membrane;Memory;memory recognition;Meningeal;Meninges;Mentors;Methods;Molecular;Motor;Mus;Nerve Degeneration;neuroimmunology;Neurons;neuroregulation;neutrophil;Neutrophil Infiltration;novel;Organ;Organism;Output;Peripheral;Phase;Physiology;Play;Population;Prefrontal Cortex;progenitor;receptor;Regulation;Research;Role;Shapes;skills;Slice;Social Interaction;Source;Spleen;Subarachnoid Hemorrhage;T-Lymphocyte;Techniques;Tissues;transcriptome sequencing;Work

PROJECT_TITLE: Defining the role of meningeal neutrophils in cognition


ADMINISTERING_IC: DA

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Opioid Misuse and Addiction;Opioids;Pediatric;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: BLACKSBURG

ORG_DEPT: MISCELLANEOUS

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

PHR: PROJECT NARRATIVE Various adverse and protective environments may affect child development. The Healthy Brain and Child Development National Consortium (HBCD-NC) will follow 7,500 mothers and their children from 24 locations across the U.S. from before birth to 10 years of age to better understand which harmful and protective environments exert the greatest impact on child development. This study will help to improve the health and development of children across the nation.

PI_NAMEs: BELL, MARTHA ANN ;HOSIG, KATHRYN W;HOWELL, BRITTANY ROLLINS (contact)

PROGRAM_OFFICER_NAME: PRABHAKAR, JANANI

PROJECT_TERMS: 10 year old;Address;Adverse event;Affect;Alcohols;Behavioral;Biological;Birth;Brain;Caregivers;caregiving;Child;child bearing;Child Development;cohort;Communities;Conceptions;COVID-19;critical period;Data;Data Collection;Data Coordinating Center;data integrity;Data Set;data standards;design;Development;DNA;early experience;early life exposure;Electroencephalography;Enrollment;Environment;Environmental Exposure;Environmental Hazards;Epigenetic Process;Ethics;Ethnic Origin;Event;experience;Exposure to;Feedback;General Population;Genes;Goals;hazard;Health;Helping to End Addiction Long-term;Human;improved;Infant;Infection;innovation;insight;Life;Link;Location;Magnetic Resonance Imaging;Malnutrition;maltreatment;Marijuana;Maternal Health;maternal stress;Measures;Methods;Modality;Monitor;Mothers;multidimensional data;multimodality;neurodevelopment;neuroimaging;Newborn Infant;novel;Opiate Addiction;Opioid;opioid misuse;Outcome;Participant;Persons;Physiological;Population;postnatal;Pregnancy;pregnant;Pregnant Women;prenatal;prenatal exposure;Process;protective factors;Protocols documentation;psychologic;Psychopathology;Public Health;Public Policy;Race;recruit;remote assessment;Research;Research Design;Research Personnel;Sampling;Second Pregnancy Trimester;Severities;Shapes;Site;socioeconomics;sound;Speed;Stress;Structural Racism;substance use;Time;Time Study;Tobacco;tool;Toxicant exposure;Training;United States;United States National Institutes of Health;Woman;Work

PROJECT_TITLE: 22/24 Healthy Brain and Child Development National Consortium

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-D(51)R]


ADMINISTERING_IC: AI

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Burden of Illness;Climate-Related Exposures and Conditions;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Patient Safety;Prevention;Rare Diseases;Social Determinants of Health

ORG_CITY: KANSAS CITY

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF MISSOURI KANSAS CITY

PHR: NARRATIVE Fungal diseases in the U.S. have been increasing in incidence and geographic distribution, with disproportionate effects in communities with high socioeconomic vulnerability. While many fungal pathogens are thought to be climate sensitive, a poor understanding of fungal disease epidemiology coupled with limited surveillance data on fungal infections has prevented a mechanistic and quantitative understanding of the role of climate variability and extreme events on fungal disease incidence. This project will use a massive electronic health record and infectious disease surveillance database to characterize relationships between climate conditions and incidence of major fungal diseases across the U.S., quantify the historical and projected effects of anthropogenic climate change on incidence rates, and examine the role of social disadvantage in exacerbating future impacts.

PI_NAMEs: HOFFMAN, MARK ;REMAIS, JUSTIN V;WHITE, THEODORE C. (contact)

PROGRAM_OFFICER_NAME: LOVE, DONA

PROJECT_TERMS: Address;Affect;Age;anthropogenesis;anti-fungal agents;Area;Aridity;Arthrodermataceae;Aspergillosis;Blastomycosis;California;Candidiasis;Case Study;Cities;Climate;climate change;climate impact;climate variability;Clinical;clinical encounter;Coccidioidomycosis;Communicable Diseases;Communities;community-level factor;comorbidity;Coupled;Cryptococcosis;Cryptococcus gattii;Data;Data Set;Databases;Death Rate;deprivation;Digit structure;Disease;disease disparity;Disease Outcome;Disease Surveillance;disorder risk;dust storms;Economics;Electronic Health Record;emerging pathogen;Environment;Environmental Risk Factor;Epidemiology;epidemiology study;Ethnic Origin;Event;experience;Face;Floods;Frequencies;Fungal Drug Resistance;Future;Geographic Distribution;Geographic Locations;Geography;Habitats;Health;health data;health disparity;health equity;Health protection;Heat Waves;Heterogeneity;high risk population;Histoplasmosis;hospitalization rates;Housing;Human;Humidity;Hurricane;Immunocompromised Host;improved;Incidence;Income;indexing;Individual;Infrastructure;Investments;Kansas;Location;Longitudinal trends;low socioeconomic status;Mediating;Meta-Analysis;Methods;Modernization;Mycoses;Neighborhoods;Outcome;pathogen;pathogenic fungus;Patients;payment;Policy Maker;Population;Precipitation;Prevalence;prevent;Public Health;Race;Reproduction spores;Research;resilience;Resources;response;Risk;Risk Estimate;Risk Factors;Role;Sample Size;Seasons;Series;Severities;social disparities;social vulnerability;Socioeconomic Status;socioeconomics;soft tissue;Soil;spatiotemporal;surveillance data;Surveys;System;Temperature;Testing;Time;Tornadoes;transmission process;trend;Visit;Vulnerable Populations

PROJECT_TITLE: Using massive, multi-regional EHR data to estimate the impacts of climate change on fungal disease epidemiology in the U.S.

STUDY_SECTION: PRID

STUDY_SECTION_NAME: Population based Research in Infectious Disease Study Section[PRID]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Genetics;HIV/AIDS;Infectious Diseases;Rare Diseases;Tuberculosis

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PROJECT NARRATIVE Tuberculosis is the leading infectious cause of death. Tuberculosis genomic information allows the transmission patterns of drug-resistant tuberculosis to be better understood and can lead to future interventions to find and interrupt chains of transmission in high-burden settings.

PI_NAMEs: BERHANU, REBECCA HAFKIN (contact)

PROGRAM_OFFICER_NAME: HUEBNER, ROBIN E

PROJECT_TERMS: Africa South of the Sahara;antiretroviral therapy;Area;Award;Back;Bioinformatics;Biometry;Boston;case finding;Cause of Death;CD4 Lymphocyte Count;Church;Cities;Clinical;Clinical Research;Cluster Analysis;co-infection;cohort;Communicable Diseases;Contact Tracing;Coupled;Data;Data Sources;density;Drug resistance;Drug resistance in tuberculosis;Drug usage;Educational workshop;Enrollment;Epidemiology;experience;Foundations;Funding;Future;Genome;genome sequencing;genomic data;Genomics;global health;Head;High Prevalence;HIV;HIV Infections;HIV/TB;Household;Housing;insight;instructor;International;Interruption;Intervention;Knowledge;Link;Literature;Location;Medicine;Mentors;Mentorship;Methodology;Methods;mid-career faculty;Minisatellite Repeats;Molecular;molecular clock;Molecular Epidemiology;Multi-Drug Resistance;Multidrug-Resistant Tuberculosis;Mutation;Participant;Patients;Pattern;Persons;Pharmaceutical Preparations;Phylogenetic Analysis;Population;Predisposition;Prisons;professor;programs;Public Health Schools;Publishing;repository;Research;Research Activity;Research Personnel;Resistance;resistance mutation;Rifampin;Risk;school health;Schools;Single Nucleotide Polymorphism;Site;skills;social;Social Network;Solid;Source;South Africa;South African;Specific qualifier value;Specimen;Testing;tool;Training;Training Activity;Translational Research;transmission process;Transportation;Trees;Tuberculosis;Tuberculosis diagnosis;Universities;whole genome;Work

PROJECT_TITLE: Transmission of drug-resistant tuberculosis in a South African city with a high prevalence of HIV infection

STUDY_SECTION: AIDS

STUDY_SECTION_NAME: Acquired Immunodeficiency Syndrome Research Study Section[AIDS]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Women's Health Research

ORG_CITY: RICHMOND

ORG_DEPT: PATHOLOGY

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

PHR: The proposed research is relevant to human health because it can directly benefit a group of cancer patients that currently have extremely poor prognosis by providing them with targeted treatment options that overcome chemotherapy resistance. Through development and testing of innovative research strategies with in vitro and in vivo models, these studies are directly in line with the mission of the National Institutes of Health; seek fundamental knowledge about living systems and apply that knowledge to enhance human health.

PI_NAMEs: HARRELL, JOSHUA (CHUCK)  (contact)

PROGRAM_OFFICER_NAME: KONDAPAKA, SUDHIR B

PROJECT_TERMS: advanced disease;Apoptosis;Apoptotic;Biological;Breast Cancer Cell;Bypass;cancer cell;Cancer Patient;Carboplatin;Cells;Cellular Stress;Cessation of life;Characteristics;Chemoresistance;Clinic;Clinical;Combined Modality Therapy;compare effectiveness;cytotoxic;cytotoxicity;Data Set;Development;Disease;Disease Management;Drug Combinations;efficacy evaluation;Epidermal Growth Factor Receptor;Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor;Estrogens;FDA approved;Genes;Genetic;Genomics;Goals;Growth;Health;Human;In Vitro;in vivo Model;Individual;inhibitor;innovation;Interferometry;Knowledge;Malignant Breast Neoplasm;Mammary Neoplasms;Mediating;Mediator;Metastatic breast cancer;Mission;Modeling;molecular drug target;Neoplasm Metastasis;new therapeutic target;novel strategies;novel therapeutic intervention;Operative Surgical Procedures;Organ;Organism;Outcome;Pathway interactions;patient derived xenograft model;Patient-derived xenograft models of breast cancer;Patients;Pharmaceutical Preparations;pharmacologic;Prognosis;Proliferating;Proteomics;Receptor Inhibition;Research;Research Proposals;Resistance;response;safety testing;Sampling;Signal Pathway;Signal Transduction;Speed;spheroids;targeted treatment;Testing;Therapeutic;transcriptome sequencing;Translating;Translations;treatment response;triple-negative invasive breast carcinoma;tumor;United States;United States National Institutes of Health;Unresectable;Work

PROJECT_TITLE: Circumventing acquired carboplatin resistance in triple-negative breast cancers

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 1 Study Section[MCT1]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Emergency Care;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Patient Safety;Prevention;Suicide;Suicide Prevention;Violence Research

ORG_CITY: ANN ARBOR

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Warning signs signal immediate risk for suicidal behavior and their assessment is of critical importance in acute care settings including emergency departments and crisis lines. This innovative 4-year study analyzes adult hospital patients’ stories of their suicide attempts in their own words and through systematic review of the hours leading up to the attempt. The project is designed to discover warning signs that have been overlooked, to clarify which warning signs confer especially high risk, and to explore the language patients use to describe warning signs, results that are critical to improve risk assessment in acute care settings.

PI_NAMEs: BAGGE, COURTNEY L (contact);CONNER, KENNETH R

PROGRAM_OFFICER_NAME: RUDORFER, MATTHEW V

PROJECT_TERMS: Academic Medical Centers;Accident and Emergency department;acute care;Address;Admission activity;Adult;Algorithms;candidate validation;Caring;Cause of Death;Clinical;clinical decision-making;clinical risk;Code;Collaborations;community setting;Crossover Design;Data;deep learning model;design;detection method;Development;Distal;Education;Emergency treatment;Event;experience;Family;Formulation;Healthcare;high risk;Hospitalization;Hospitals;Hour;improved;Incidence;Individual;innovation;Interview;Language;Learning;Life;Linguistics;member;Methodology;Methods;Midwestern United States;Modeling;mortality risk;National Institute of Mental Health;Natural Language Processing;novel;patient safety;Patients;Prevention;Process;programs;prospective;Provider;Recording of previous events;recruit;Research;Risk;Risk Assessment;Risk Estimate;Risk Factors;Sampling;Signal Transduction;Site;Structure;suicidal;suicidal act;suicidal behavior;suicidal risk;Suicide;Suicide attempt;Suicide prevention;suicide rate;support tools;systematic review;Testing;Time;tool;Training;Transcript;Validation;validation studies;Work

PROJECT_TITLE: Mixed methods examination of warning signs within 24 hours of suicide attempt in hospitalized adults

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HSS-P(90)S]


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: ATLANTA

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative Inequalities in cardiovascular health are a pervasive problem that has remained essentially unchanged over the past several decades in the United States. This T32 competing continuation application proposes to train the next generation of leading researchers to pioneer innovative research using a multidisciplinary approach in order to reduce cardiovascular health disparities.

PI_NAMEs: VACCARINO, VIOLA  (contact)

PROGRAM_OFFICER_NAME: REDMOND, NICOLE

PROJECT_TERMS: cardiovascular health;Inequality;Interdisciplinary Study;Research Training

PROJECT_TITLE: Multidisciplinary Research Training to Reduce Inequalities in Cardiovascular Health


ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE The recent emergence of type 2 diabetes (T2D) among youth has significant public health implications as young people with T2D are likely to manifest debilitating complications of diabetes during what should be the most active and productive years of their lives. There is an urgent need to need to identify children at risk for T2D and intervene appropriately earlier in the pre-clinical disease course. Our study seek to extend the longitudinal follow- up of the Healthy Start (HS) Cohort, a maternal-offspring dyad study that enrolled 1410 pregnant women and conducted detailed characterization of mothers during pregnancy, of offspring through age ~7 years (R01DK076648), and ongoing at ages 8-10 years (through the Environmental Influences on Child Health Outcomes –ECHO- Consortium, UH3OD023248). This in depth characterization coupled with the proposed follow-up (ages ~10-15) will improve our understanding of early life course pathways influencing pubertal metabolic homeostasis. This foundational knowledge on youth-onset T2D pathophysiology is needed to inform potential prevention approaches.

PI_NAMEs: DABELEA, DANA  (contact);KELSEY, MEGAN MORIARTY

PROGRAM_OFFICER_NAME: LINDER, BARBARA

PROJECT_TERMS: Address;Adult;Affect;Age;Area;Beta Cell;Child;Child Behavior;Child Health;cohort;Cohort Studies;Communities;Complications of Diabetes Mellitus;Coupled;Cross-Sectional Studies;Deposition;Development;Diabetes Mellitus;diabetes risk;Diet;Disease;early life exposure;Enrollment;Ethnic Origin;Ethnic Population;Exposure to;Failure;Fasting;Fatty acid glycerol esters;feeding;follow-up;Functional disorder;Future;gene environment interaction;Genetic;Genetic Predisposition to Disease;genetic risk factor;girls;Glucose;Goals;Health;Hepatic;Homeostasis;improved;in utero;Infant;Insulin;Insulin Resistance;insulin sensitivity;Knowledge;Life;Life Cycle Stages;Link;Liver;Longitudinal Studies;maternal diabetes;Measures;Mediating;Metabolic;Metabolic Marker;Metabolism;Morbidity - disease rate;mortality;Mothers;Non-Insulin-Dependent Diabetes Mellitus;Obesity;obesity in children;offspring;OGTT;Outcome;Overnutrition;Pathway interactions;Persons;Physical activity;Physiological;polygenic risk score;pre-clinical;Pregnancy;Pregnant Women;prevent;Prevention approach;Productivity;Puberty;puberty transition;Public Health;Race;racial minority population;Research;response;Risk;Risk Factors;sex;social stress;sociodemographic factors;Time;trait;trend;Weight Gain;Work;Youth

PROJECT_TITLE: Metabolic Health during Puberty: the Healthy Start Study

STUDY_SECTION: HSDO

STUDY_SECTION_NAME: Human Studies of Diabetes and Obesity Study Section[HSDO]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease

ORG_CITY: CAMBRIDGE

ORG_NAME: ADA FORSYTH INSTITUTE, INC.

ORG_STATE: MA

PHR: Project Narrative This T90/R90 postdoctoral and DMD/PhD training program is intended to provide research training and research education experiences to US and non-US citizens, positioning them as investigators who can successfully compete for research funds in areas of oral health research, clearly and effectively communicate their thoughts both orally and on paper, recognize the value of collaborative and multidisciplinary research interactions, lead and inspire others to accomplish mutual research objectives, know how to translate their findings to practice, be ethical in their decision-making processes, harmonious in their relationships with other scientists, and who know how to acquire new skills as their careers advance.

PI_NAMEs: VAN DYKE, THOMAS ELLIOTT (contact)

PROGRAM_OFFICER_NAME: MCGUIRL, MICHELE

PROJECT_TERMS: Advisory Committees;Applications Grants;Appointment;career;Clinical;Committee Members;Communication;craniofacial;Dental Schools;Dentists;Disease;Doctor of Philosophy;Educational process of instructing;Educational workshop;Elements;Environment;experience;Feedback;Funding;Future;Grant;Grant Review;Health;High School Student;Individual;Interdisciplinary Study;Investigation;medical schools;Medicine;Mentors;Methods;Nevada;North Carolina;Oral;Oral health;post-doctoral training;Postdoctoral Fellow;pre-doctoral;Preparation;Program Reviews;programs;recruit;Reproducibility;Research;research and development;Research Personnel;Research Training;responsible research conduct;Scientist;skills;summer research;Time;Training;Training Programs;United States National Institutes of Health;Universities;Writing

PROJECT_TITLE: Forsyth Training in Oral Health Research


ADMINISTERING_IC: ES

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

ORG_CITY: AMHERST

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

ORG_STATE: NY

PHR: PROJECT NARRATIVE Throughout their lives, children are exposed to many different chemicals but our understanding of the effects of these mixtures on child health is limited. Our research is relevant to public health: it will inform prevention efforts and communication of risks by creating a deeper understanding of how exposure to chemical mixtures affects oxidative stress and cognition in children and how well the body's antioxidant defenses are able to counteract these effects. Our work is also relevant to the mission of the NIEHS: it will contribute fundamental knowledge on environmental influences on disease.

PI_NAMEs: KORDAS, KATARZYNA  (contact);QUEIROLO, ELENA I

PROGRAM_OFFICER_NAME: JOUBERT, BONNIE

PROJECT_TERMS: Address;Affect;Age;aged;All-Trans-Retinol;antioxidant enzyme;Antioxidants;Area;Aromatic Polycyclic Hydrocarbons;aryldialkylphosphatase;Ascorbic Acid;Behavior;Behavioral;Biological;Biological Factors;Biological Markers;Biological Process;Blood;Body mass index;Brain;Buffers;Carotenoids;Chemicals;Child;Child Health;Childhood;Chlorpyrifos;Chronic;Chronic Disease;Cognition;cognitive ability;cognitive function;cognitive performance;cohort;Communication;Communities;Complex;Complex Mixtures;Data;Development;Disease;early adolescence;Enrollment;environmental chemical;Environmental Exposure;Environmental Health;Environmental Risk Factor;enzyme activity;executive function;experience;Exposure to;F2-Isoprostanes;first grade;follow-up;Foundations;Funding;Future;glutathione peroxidase;Goals;Growth;Health;Human;improved;Income;individual variation;Infrastructure;Knowledge;Learning;Life;Life Cycle Stages;Link;Literature;machine learning model;Measures;Mediation;Memory;Metal exposure;Metals;middle childhood;Mission;Modeling;Modification;Molecular;National Institute of Environmental Health Sciences;Neurocognitive;Outcome;oxidative DNA damage;Oxidative Stress;Participant;Performance;Pesticides;Pilot Projects;Play;Prevention;Process;Puberty;Public Health;pyrethroid;Regulation;Research;response;Risk;Risk Assessment;Role;sample collection;Schools;Serum;sex;Social Interaction;statistical and machine learning;Strategic Planning;success;Testing;Time;Tocopherols;urinary;Urine;Uruguay;Vitamins;Work

PROJECT_TITLE: Effect of complex mixtures on oxidative stress and cognition in children

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-K(02)]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Microbiome

ORG_DEPT: CHEMISTRY

PHR: Project description  Sterols are critical for the structure of eukaryotic cells and serve as important signaling molecules. Some bacteria also engage with these lipids, but the molecular mechanisms of these engagements are not known. Inspired by our recent discovery of bacterial proteins that transport sterols, we seek to uncover the molecular determinants of sterol recognition and transport in other bacteria, including pathogens and the gut microbiome.

PI_NAMEs: DASSAMA, LAURA  (contact)

PROGRAM_OFFICER_NAME: NIE, ZHONGZHEN

PROJECT_TERMS: Archaea;Bacteria;Bacterial Proteins;Bioinformatics;Biological;Borrelia burgdorferi;Cardiometabolic Disease;cell envelope;Cell Physiology;Chlamydia;Cholesterol;Dyslipidemias;Eukaryota;Eukaryotic Cell;Event;Family;fluidity;Genomic approach;Genus Mycobacterium;gut microbes;gut microbiome;gut microbiota;Homologous Gene;Homologous Protein;hydrophilicity;Hydrophobicity;insight;Knowledge;Ligand Binding;Ligands;lipid metabolism;lipid transport;Lipids;Lipoproteins;Mammalian Cell;member;Membrane;Metabolism;Methylococcus capsulatus;microorganism interaction;Molecular;new therapeutic target;Order Spirochaetales;pathogen;Pathogenicity;Periplasmic Binding Proteins;phosphonate;protein transport;Proteins;Regulation;Reporting;Research;Resistance;Rickettsia;Signal Transduction;Signaling Molecule;Site;Sterol Biosynthesis Pathway;Sterols;stress tolerance;structural genomics;Structure;Therapeutic Intervention;trafficking;Treponema pallidum;Work

PROJECT_TITLE: Deciphering the molecular mechanisms of sterol lipid trafficking in bacteria

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


ADMINISTERING_IC: HG

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Genetic Testing;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Human Genome;Precision Medicine;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: GAINESVILLE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE This proposed research is relevant to human health because preemptive clinical pharmacogenetic testing may improve the personalization of drug therapy which should improve patient outcomes. Better understanding of the effectiveness and feasibility of preemptive clinical pharmacogenetic testing will inform when and how this innovative healthcare technology is implemented into clinical care. To ensure equitable dissemination in all patient populations, such data is also needed in racial minorities and other traditionally underserved populations. The combined proposed research are relevant to the parts of the NIH's mission pertaining to protecting and improving health and developing scientific human resources that will ensure the Nation's capability to prevent and treat disease.

PI_NAMEs: DUARTE, JULIO DAVID (contact)

PROGRAM_OFFICER_NAME: CHANG, CHRISTINE Q

PROJECT_TERMS: Academic Medical Centers;Address;Affect;African American;Appointment;Area;barrier to testing;Clinical;clinical care;Clinical Data;clinical implementation;clinical outcome assessment;clinical practice;Clinical Trials;cost;Cost Savings;Data;design;Disease;Disparity;disparity reduction;Drug Prescriptions;Drug usage;Effectiveness;Ensure;Equity;Exclusion;Feasibility Studies;Florida;Future;Genetic Variation;Genotype;Geography;Goals;Guidelines;Health;health care disparity;health care quality;Health Personnel;Health system;Health Technology;Human;Human Resources;implementation efforts;improved;innovation;innovative technologies;Insurance Carriers;Interview;Low income;medically underserved;medically underserved population;member;Mission;new technology;off-patent;open label;Outcome;patient population;Patient-Focused Outcomes;Patients;Pattern;Perception;Pharmaceutical Preparations;pharmacogenetic testing;Pharmacogenetics;Pharmacotherapy;Population;precision drugs;precision medicine;prevent;Primary Care;programs;Race;racial minority;racial minority population;Randomized;Research;response;satisfaction;Socioeconomic Factors;socioeconomics;Structure;Technology;Testing;treatment as usual;treatment disparity;trial comparing;Underserved Population;Uninsured Medical Expense;United States National Institutes of Health;Variant;willingness to pay

PROJECT_TITLE: Preemptive pharmacogenetic testing in medically underserved populations


ADMINISTERING_IC: OD

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

ORG_DEPT: VETERINARY SCIENCES

PHR: PROJECT NARRATIVE Mouse models are a cornerstone of basic research and the development of therapeutic interventions. The NIH Mutant Mouse Resource & Research Centers (MMRRC) are a group of four repositories (University of California, University of Missouri, University of North Carolina, and The Jackson Laboratories) that collectively curate and distribute mouse strains. The Informatics, Coordination and Service Center (ICSC) funded under this opportunity provides organizational leadership, quality management, and informatics services for the MMRRC to enable cryopreservation, cataloging, and distribution of almost 60,000 mouse strains, embryonic stem cell lines, plasmid vectors, and antibody-producing hybridoma to the research community for the advancement of human health.

PI_NAMEs: KORF, IAN F (contact)

PROGRAM_OFFICER_NAME: MIROCHNITCHENKO, OLEG

PROJECT_TERMS: Alleles;Antibodies;Applied Research;Awareness;base;Basic Science;Biomedical Research;Breeding;California;Cataloging;Catalogs;Cell Line;ClinVar;Collaborations;Communication;Communities;community center;Cryopreservation;Data;data curation;Data Security;Data Storage and Retrieval;Databases;design;Development;Education;Education and Outreach;Electronic Mail;Embryo;Ensure;ES Cell Line;Evaluation;Experimental Designs;Feedback;Funding;Funding Opportunities;Genetic Engineering;Germ;Health;Health Sciences;high standard;Human;Hybridomas;Informatics;Information Centers;Information Services;Information Technology;innovation;Internet;Journals;Lead;Leadership;Literature;Maintenance;Marketing;Mission;Missouri;mouse model;Mouse Strains;Mus;Mutant Strains Mice;Mutate;North Carolina;Online Mendelian Inheritance In Man;Online Systems;operation;outreach;Persons;Plasmid Cloning Vector;Play;Process;programs;Progress Reports;public education;Public Relations;PubMed;Quality Control;Records;relational database;Reporting;repository;Reproducibility;Reproducibility of Results;Research;Research Project Grants;Resources;Role;Secure;service providers;Services;Site Visit;social media;stem;Structure;success;symposium;Telephone;The Jackson Laboratory;therapeutic development;Therapeutic Intervention;Time;tool development;United States National Institutes of Health;Universities;Vertebral column;web site

PROJECT_TITLE: Informatics, Coordination and Service Center for the Mutant Mouse Resource and Research Centers


NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: ITHACA

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: CORNELL UNIVERSITY

PHR: PROJECT NARRATIVE The human genome contains roughly 25 thousand genes and over 1 million regions that are implicated in determining the level, timing, and place of expression of these genes. In spite of substantial effort, our understanding of the architecture of these regulatory regions and how they communicate and regulate gene expression is far from complete. In this project, we will comprehensively characterize these regulatory regions from two human chromosomes and study their function at multiple levels to better understand the control of gene expression in normal and disease conditions.

PI_NAMEs: LIS, JOHN T (contact);YU, HAIYUAN

PROGRAM_OFFICER_NAME: PAZIN, MICHAEL J

PROJECT_TERMS: Architecture;Bar Codes;Base Pairing;Binding;Biological Assay;Capsicum;CCRL2 gene;Chromatin Conformation Capture and Sequencing;Chromosomes;Code;Communication;Complex;Disease;Dissection;DNA;DNA Polymerase II;Elements;Enhancers;Gene Expression;Gene Expression Regulation;Genes;Genetic Enhancer Element;Genetic Transcription;Genomics;global run on sequencing;Goals;Histones;Human;Human Chromosomes;Human Genome;human study;Hypersensitivity;insight;K-562;K562 Cells;Maps;Measures;Messenger RNA;Methods;Modeling;Molecular;mRNA Stability;Mutagenesis;mutant;Mutate;NMU gene;Normal Cell;novel;Nucleic Acid Regulatory Sequences;Precision Run-On Sequencing;Productivity;promoter;Property;Regulation;Regulator Genes;Reporter;Reporting;RNA;Role;Site;Specificity;System;Testing;Transcript;transcription factor;Transcription Initiation;Transcription Initiation Site;Upstream Enhancer;Work

PROJECT_TITLE: Functional Architecture and Interplay of Transcription Regulatory Elements of the Human Genome

STUDY_SECTION: MG

STUDY_SECTION_NAME: Molecular Genetics Study Section[MG]


ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PROJECT_TERMS: Accounting;Archives;Collaborations;Communication;Coordination and Collaboration;Documentation;Ensure;Evaluation;Goals;Guidelines;improved;Informatics;Information Services;Information Technology;Marketing;meetings;member;Mutant Strains Mice;Outcome;outreach;Policies;Process;programs;Progress Reports;Protocols documentation;Published Comment;Publishing;Reporting;repository;Research;Resolution;Resources;Secure;Services;Site Visit;Structure;System;Teleconferences;United States National Institutes of Health;Update;web site;Work

PROJECT_TITLE: ICSC Core - Coordination

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IMST-K]


NIH_SPENDING_CATS: Genetics

PROJECT_TERMS: Awareness;biobank;Biomedical Research;Catalogs;Collaborations;Collection;Communication;Communities;disease model;Documentation;Education;Electronic Mail;Feedback;Genes;Goals;Human Resources;Informatics;interest;International;Journals;Knowledge;Learning;Link;Marketing;material transfer agreement;MeSH Thesaurus;Methods;mouse model;Mus;Mutant Strains Mice;Names;Online Systems;Ontology;outreach;Phenotype;phrases;Process;programs;prospective;Public Relations;Publications;repository;Reproducibility;Research;Research Personnel;Research Support;Resources;Science;Secure;Services;social media;symposium;Technical Expertise;United States National Institutes of Health;web site

PROJECT_TITLE: ICSC Core - Customer Service and Public Relations


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Mental Illness;Psychosis;Racial and Ethnic Minority Health Research;Rural Health;Schizophrenia;Serious Mental Illness;Social Determinants of Health

ORG_CITY: PULLMAN

ORG_NAME: WASHINGTON STATE UNIVERSITY

ORG_STATE: WA

PHR: PROJECT NARRATIVE  The proposed study is highly relevant to public health because it examines the extent to which health disparity populations have access to the standard of care for early psychosis, coordinated specialty care programs, and whether access to services vary based on neighborhood-level characteristics. Due to the widespread dissemination of coordinated specialty care programs throughout the US, the examination of whether youth and families have equitable access to such services is the first step. Given the documented disparities in service utilization and difficulties experienced along the pathways to coordinated specialty care, the present study is critical to understanding these inequities, and aligns with NIMH strategic goals.

PI_NAMEs: OLUWOYE, OLADUNNI  (contact)

PROGRAM_OFFICER_NAME: MAVANDADI, SHAHRZAD

PROJECT_TERMS: 20 year old;access disparities;Address;Administrator;Age;Area;built environment;care systems;Caring;Censuses;Characteristics;Client;Communities;Coordinated Specialty Care;Credentialing;dashboard;Data;Data Set;Databases;Decision Aid;density;deprivation;Development;Disadvantaged;Disparity;disparity reduction;duration of untreated psychosis;Early Intervention;early onset;early psychosis;economic disparity;Effectiveness;Environment;Equity;ethnic diversity;Ethnic Origin;evidence base;experience;Family;first episode psychosis;Focus Groups;Funding;future implementation;Gender;geographic disparity;Geographic Distribution;Geographic Locations;Geography;Goals;Grant;health determinants;health disparity populations;Health Services Accessibility;improved;Incidence;Individual;inequitable distribution;Inequity;Internet;Link;Location;Maps;Measures;medical specialties;Mental Health;Mental Health Services;National Institute of Mental Health;Neighborhoods;novel;Outcome;Pathway interactions;payment;Persons;Policies;Policy Maker;programs;Provider;psychiatric symptom;Psychoses;Public Health;Quality of life;Race;racial disparity;racial diversity;Racial Segregation;Recovery;Research;Research Support;residential segregation;Resources;Role;Rural;rurality;Schizophrenia;service gap;service intervention;service utilization;Services;sex;social culture;social determinants;social disparities;socioeconomic disparity;socioeconomics;Spatial Distribution;standard of care;Structure;Techniques;Technology;technology development;Time;tool;Transportation;Underserved Population;Urbanization;Variant;Visualization;Washington;Work;Youth

PROJECT_TITLE: Geographic Disparities in the Availability and Accessibility of Coordinated Specialty Care Programs for Early Psychosis

STUDY_SECTION: SERV

STUDY_SECTION_NAME: Mental Health Services Study Section[SERV]


NIH_SPENDING_CATS: Genetics;Networking and Information Technology R&D (NITRD)

PROJECT_TERMS: Adherence;Agreement;Alleles;Aloral;application programming interface;Applied Research;Archives;base;Bioinformatics;Biological;Catalogs;central database;Communication;Communities;Data;data access;data acquisition;data curation;data exchange;data quality;Database Management Systems;Databases;design;Development;digital;Electronics;Etiology;Genes;Genetic;Goals;Health;human disease;Individual;Industry Standard;Informatics;informatics tool;Information Technology;interactive visualization;Internet;Intervention;Legal;Licensing;Maintenance;Marketing;material transfer agreement;meetings;member;Metric System;Mutant Strains Mice;Nomenclature;outreach;Performance;Phenotype;Policies;Price;Process;programs;Protocols documentation;Publications;PubMed;relational database;Reporting;repository;Research;Research Personnel;Research Project Grants;Resources;response;Risk;Secure;Security;Services;Site;statistics;Structure;success;System;tool;United States National Institutes of Health;Update;Vertebral column;web app;web interface;web services;web site;Work;Writing

PROJECT_TITLE: ICSC Core - Informatics


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Drug Abuse (NIDA only);Harm Reduction for Substance Misuse;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

ORG_CITY: RESEARCH TRIANGLE PARK

ORG_NAME: RESEARCH TRIANGLE INSTITUTE

ORG_STATE: NC

PHR: PROJECT NARRATIVE In the past 5 years, opioid overdose mortality rates increased 114% among Black, 97% among Latinx, and 32% among White populations in the United States. Naloxone is an evidence-based intervention to prevent opioid overdose deaths, yet access to this lifesaving intervention is insufficient and inequitable. We will contribute directly to the improvement of minority health and the reduction of health inequities by conducting a randomized controlled trial to test the effectiveness and cost-effectiveness of the systems analysis and improvement approach to increase and improve equitable naloxone distribution in syringe service programs.

PI_NAMEs: LAMBDIN, BARROT HOPKINS (contact)

PROGRAM_OFFICER_NAME: ZUR, JULIA BETH

PROJECT_TERMS: acceptability and feasibility;Address;Affect;Area;arm;Black Populations;Black race;Black, Indigenous, People of Color;California;Caring;Consensus;cost;cost effectiveness;cost estimate;Country;cultural competence;Data;Death Rate;design;disparity reduction;Drops;Effectiveness of Interventions;effectiveness testing;Equity;Event;Evidence based intervention;experience;Goals;Health;health care disparity;health care service;health inequalities;implementation strategy;improve minority health;improved;Indigenous;Inequity;Injecting drug user;Interruption;Intervention;Latinx;Latinx population;Life;Maps;Modification;mortality;Naloxone;naloxone dispensing;naloxone dosing;Needle-Exchange Programs;Opioid Antagonist;opioid mortality;opioid overdose;Outcome;Overdose;overdose death;Participant;patient engagement;Penetration;people of color;Performance;Persons;Pilot Projects;Population;prevent;Principal Investigator;Process;programs;Randomized;Randomized, Controlled Trials;Reduce health disparities;Research;Research Personnel;response;screening;Series;Services;Support System;System;Systems Analysis;Testing;therapy design;Time;Training;treatment as usual;Trust;United States;United States Dept. of Health and Human Services;United States Substance Abuse and Mental Health Services Administration;Work

PROJECT_TITLE: Improving Equitable Access to Naloxone to Prevent Opioid Overdose Deaths Within Syringe Service Programs

STUDY_SECTION: HHD

STUDY_SECTION_NAME: Healthcare and Health Disparities Study Section[HHD]


PROJECT_TERMS: Acceleration;Accountability;Address;Affect;Applied Research;Archives;Back;Basic Science;Clustered Regularly Interspaced Short Palindromic Repeats;Communities;comparative;cost;Costs and Benefits;Data;Databases;design;Disease;Fingerprint;Future;Genetic Diseases;Genome;Health;health science research;Human;improved;Informatics;interest;invention;Journals;Learning;life span;Malignant Neoplasms;Measurement;Measures;model organism;mouse model;Mus;Mutant Strains Mice;NIH Mouse;NON Mouse;Ontology;Paper;pathogen;Physiological;programs;Publications;Recording of previous events;repository;Reproducibility;Reproduction;Research;Research Design;Research Personnel;Research Project Grants;Research Project Summaries;Research Support;Resolution;Resources;Scientist;Services;Standard Model;Technology;Translational Research;United States National Institutes of Health

PROJECT_TITLE: ICSC Applied Research Project


ORG_CITY: SAINT LOUIS

ORG_DEPT: BIOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

PHR: Project Narrative The centriole-cilium complex is a conserved structure that organizes hundreds of proteins for cell signaling and motility, and misregulation of this complex is linked to a wide range of human diseases and syndromes. The defining features of this complex are compound microtubules, which are a unique arrangement of microtubules linked together. This proposal will determine how compound microtubules are formed, with the goal of improving our understanding of how these important cellular structures are organized to create a unique hub of signaling and function within the cell.

PI_NAMEs: WANG, JENNIFER TONG (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TERMS: Affect;alpha Tubulin;Award;beta Tubulin;Biological Assay;career;career development;Cell Cycle;cell motility;Cells;Cellular biology;Cellular Structures;Centrioles;Centrosome;Cilia;ciliopathy;Complex;CRISPR/Cas technology;Cryoelectron Microscopy;Cytoskeleton;daughter cell;Defect;Dependence;Development;Disease;Eukaryota;Foundations;Future;Genetic;Goals;Health;Human;Human Development;human disease;improved;In Vitro;in vitro Assay;in vivo;Inherited;insight;Label;Lighting;Link;Malignant Neoplasms;Maps;Mediating;member;Mentors;Microcephaly;Microscopy;Microtubule Triplet;Microtubules;Molecular;Morphology;Mothers;mutant;Organelles;Organism;organizational structure;Phase;Postdoctoral Fellow;protein transport;Proteins;reconstitution;recruit;Research;Research Technics;Rest;Role;self organization;Signal Transduction;skills;Structure;Syndrome;Techniques;Testing;trafficking;Training;Transmission Electron Microscopy;Triplet Multiple Birth;Tubulin;Work

PROJECT_TITLE: Molecular mechanisms of centriolar triplet microtubule formation

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Brain Disorders;Genetics;Huntington's Disease;Neurodegenerative;Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: PHILADELPHIA

ORG_NAME: THOMAS JEFFERSON UNIVERSITY

ORG_STATE: PA

PHR: Huntington’s disease, a slowly progressing neurodegenerative disease caused by a CAG repeat tract expansion within the huntingtin gene, belongs to a large group of neurodegenerative diseases characterized by protein misfolding and accumulation. The studies proposed here will provide mechanistic insights into somatic CAG expansions, and could yield novel protein targets for therapeutic intervention.

PI_NAMEs: PLUCIENNIK, ANNA  (contact)

PROGRAM_OFFICER_NAME: MILLER, DANIEL L

PROJECT_TERMS: Address;Affect;Age;age acceleration;Age of Onset;age related;Animal Model;Attenuated;Binding Proteins;Biochemical;Brain region;CAG repeat;causal variant;cell type;Cells;Cerebellum;Consensus;Corpus striatum structure;Disease;DNA;DNA Interstrand Cross-Link Repair;DNA Repair;DNA Repair Pathway;Equilibrium;Excision;Fragile X Syndrome;gene repair;Genes;Genetic;Genome Stability;genome wide association study;Goals;Human;Huntington Disease;Huntington gene;Individual;induced pluripotent stem cell;Inherited;insight;Knock-in Mouse;Knock-out;Length;Maps;Mismatch Repair;MLH1 gene;Molecular;mouse model;MSH2 gene;MSH3 gene;Mus;Myotonic dystrophy type 1;Neurodegenerative Disorders;neuron loss;Neurons;novel;Onset of illness;Outcome;Pathway interactions;patient derived induced pluripotent stem cells;Patients;Phenotype;PMS1 gene;PMS2 gene;polyglutamine;Process;protein complex;protein misfolding;Proteins;Proteomics;Regulation;repaired;Role;Somatic Cell;System;targeted treatment;Testing;Therapeutic Intervention;Tissues;Trinucleotide Repeats

PROJECT_TITLE: Molecular mechanisms of triplet repeat instability in Huntington's disease

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


NIH_SPENDING_CATS: Neurosciences

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: Project Narrative  This application seeks support for renewal of the Neuroscience Graduate Program training grant at Baylor College of Medicine. The goal of this training grant is to provide a broad-based interdisciplinary training program in the neurosciences that will prepare the next generation of neuroscientists to make discoveries that will improve human health and well-being.

PI_NAMEs: RASBAND, MATTHEW N (contact)

PROGRAM_OFFICER_NAME: ULLRICH, LAUREN ELIZABETH

PROJECT_TERMS: Neurosciences;Training

PROJECT_TITLE: Graduate Training in the Neurosciences


PHR: Project Narrative Various adverse and protective environments may affect child development. The Healthy Brain and Child Development National Consortium (HBCD-NC) will follow 7,500 mothers and their children from 24 locations across the U.S. from before birth to 10 years of age to better understand which harmful and protective environments exert the greatest impact on child development. This study will help to improve the health and development of children across the nation.

PI_NAMEs: COLES, CLAIRE D.;KABLE, JULIE A (contact)

PROGRAM_OFFICER_NAME: PRABHAKAR, JANANI

PROJECT_TERMS: 10 year old;Address;Adverse event;Affect;Alcohols;Behavioral;Biological;Birth;Brain;Caregivers;caregiving;Child;child bearing;Child Development;cohort;Communities;Conceptions;COVID-19;critical period;Data;Data Collection;Data Coordinating Center;data integrity;Data Set;data standards;design;Development;DNA;early experience;early life exposure;Electroencephalography;Enrollment;Environment;Environmental Exposure;Environmental Hazards;Epigenetic Process;Ethics;Ethnic Origin;Event;experience;Exposure to;Feedback;General Population;Genes;Goals;hazard;Health;Helping to End Addiction Long-term;Human;improved;Infant;Infection;innovation;insight;Life;Link;Location;Magnetic Resonance Imaging;Malnutrition;maltreatment;Marijuana;Maternal Health;maternal stress;Measures;Methods;Modality;Monitor;Mothers;multidimensional data;multimodality;neurodevelopment;neuroimaging;Newborn Infant;novel;Opiate Addiction;Opioid;opioid misuse;Outcome;Participant;Persons;Physiological;Population;postnatal;Pregnancy;pregnant;Pregnant Women;prenatal;prenatal exposure;Process;protective factors;Protocols documentation;psychologic;Psychopathology;Public Health;Public Policy;Race;recruit;remote assessment;Research;Research Design;Research Personnel;Sampling;Second Pregnancy Trimester;Severities;Shapes;Site;socioeconomics;sound;Speed;stem;Stress;Structural Racism;substance use;Time;Time Study;Tobacco;tool;Toxicant exposure;Training;United States;United States National Institutes of Health;Woman;Work

PROJECT_TITLE: 4/24 Healthy Brain and Child Development National Consortium


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Biomedical Imaging;Cardiovascular

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

PHR: Program Director/Principal Investigator (Last, First, Middle): Kramer, Christopher M. Nearly one in 3 deaths in the U.S. is due to cardiovascular disease, most due to coronary heart disease. The need for improved noninvasive methods to detect early disease and to help manage chronic disease has never been as critical. Training academic clinician investigators in the physics, engineering, and translational research approaches to cardiovascular imaging is essential to future improvements. PHS 398/2590 (Rev. 06/09) Page Continuation Format Page

PI_NAMEs: LINDNER, JONATHAN R (contact)

PROGRAM_OFFICER_NAME: ERIM, ZEYNEP

PROJECT_TITLE: Training in Cardiovascular Imaging Research


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Genetics;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: BALTIMORE

ORG_DEPT: UROLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative Medulloblastoma requires aggressive therapy in all cases. It frequently recurs as resistance to treatment and is associated with high morbidity and mortality. Also, affected individuals often suffer from disorders secondary to therapy.

PI_NAMEs: PERERA, RANJAN JOSEPH (contact)

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: 3-Dimensional;Address;Affect;aggressive therapy;Antisense Oligonucleotides;Binding Proteins;Brain;Brain Neoplasms;cancer type;Cell Physiology;Cell Proliferation;Cells;Central Nervous System Neoplasms;Cerebellum;Cerebrospinal Fluid;cerium oxide nanoparticle;Child;Cisplatin;Citric Acid Cycle;Clinical;Clinical Treatment;CRISPR/Cas technology;Data;Data Set;Death Rate;Development;Diagnosis;Disease;Enzymes;Epigenetic Process;Experimental Models;Foundations;Gene Expression Profile;gene regulatory network;Genes;Genetic;genetic signature;genomic locus;H2 gene;Hematopoietic Neoplasms;Homeobox;Human;human disease;human model;Immunocompromised Host;in vivo;Individual;Induction of Apoptosis;inhibitor;innovation;insight;Invaded;lead candidate;Machine Learning;Malignant Neoplasms;Mediating;Medulloblastoma;Metabolic;Metabolic Pathway;Molecular;molecular targeted therapies;Morbidity - disease rate;mortality;mouse model;Mus;nanoparticle;Neoplasm Metastasis;Nicotinamide adenine dinucleotide;nicotinamide phosphoribosyltransferase;novel;Oligonucleotides;Oncogenes;Oncogenic;overexpression;Parents;particle;Pathway interactions;Patients;Pharmaceutical Preparations;Play;pre-clinical;Pre-Clinical Model;Preclinical Testing;Primary Neoplasm;Production;Prognosis;Recurrence;Regulation;Regulator Genes;Regulatory Element;Resistance;resistance mechanism;response;RNA-Binding Proteins;Role;Safety;Secondary to;Signal Pathway;spatiotemporal;Subgroup;targeted agent;Testing;Therapeutic;therapeutic evaluation;Therapeutic Intervention;therapeutic target;therapeutically effective;Time;transcription factor;transcriptome sequencing;treatment response;Treatment Side Effects;tumor;tumor growth;tumor metabolism;tumor progression;Untranslated RNA;Up-Regulation;Work

PROJECT_TITLE: Regulation, function, and the therapeutic potential of an oncogenic long noncoding RNA lnc-HLX-2-7 in group 3 medulloblastomas

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


NIH_SPENDING_CATS: Aging;Mental Health;Neurosciences

ORG_CITY: NEW HAVEN

ORG_DEPT: NEUROSURGERY

ORG_NAME: YALE UNIVERSITY

PHR: Project Narrative The INP training program supports the education of the next generation of neuroscience research scientists. INP graduates go on to leading positions in universities, research institutes, and industry, where they contribute to our understanding of the basic principles of the nervous system. Our students and alumni develop rational approaches to understand the outstanding problems in nervous system function, and through their research advance practical solutions for the disorders of the nervous system that afflict society.

PI_NAMEs: GREER, CHARLES A (contact);PICCIOTTO, MARINA R

PROGRAM_OFFICER_NAME: WEIGAND, LETITIA ALEXIS

PROJECT_TERMS: Neurosciences;programs

PROJECT_TITLE: Interdepartmental Neuroscience Program


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Eye Disease and Disorders of Vision;Neurosciences;Sleep Research

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Narrative Light through the eye affects both image-forming (e.g., vision) and non-image-forming physiology (e.g., sleep, circadian rhythms, melatonin, and the pupillary light response), which are important for health and resilience. We will test whether pupil responses to different light stimuli are affected by a person’s sex and age.

PI_NAMEs: KLERMAN, ELIZABETH B. (contact)

PROGRAM_OFFICER_NAME: LAPOSKY, AARON D

PROJECT_TERMS: Address;Adult;Affect;Age;age difference;age effect;age group;alertness;Area;Biological Assay;Biological Process;Biology;Brain;Cells;circadian;Circadian Rhythms;clinical application;clinical diagnostics;cognitive function;cost;Darkness;Data Analyses;data cleaning;Data Collection;design;Diagnosis;Diagnostic;Disease;Disease Outcome;disorder risk;Documentation;Electroencephalography;Equipment;Exposure to;Eye;Fostering;Future;Grouping;Health;health difference;Heart Rate;Hormones;Hour;Image;Individual;Inpatients;Intervention;Investigation;life span;Light;light effects;Lighting;Measures;melanopsin;Melatonin;men;Mental disorders;Methods;Monitor;Moods;National Heart, Lung, and Blood Institute;Nervous System Disorder;Neurologic;Outcome;Outcome Measure;Participant;Pathogenesis;Pathway interactions;personalized medicine;Persons;Phase;Physiology;portability;Process;programs;Publications;Pupil;Randomized;receptor;Reporting;Research;resilience;Resources;response;Retina;Retinal Ganglion Cells;Risk;saliva sample;Sampling;sensor;Severities;sex;Sex Differences;Sex Distribution;sex variable;Shipping;Sleep;Standardization;Stimulus;Strategic vision;study population;Symptoms;Testing;Time;tool;Training;Translations;treatment strategy;Variant;Vertebrate Photoreceptors;Vision;Visual;web site;Woman;Work

PROJECT_TITLE: Impact of sex and age on non-visual light input that affects sleep and circadian rhythms

STUDY_SECTION: BNRS

STUDY_SECTION_NAME: Behavioral Neuroendocrinology, Neuroimmunology, Rhythms, and Sleep Study Section [BNRS]


ADMINISTERING_IC: NR

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Childhood Leukemia;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Hematology;Palliative Care;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: INDIANAPOLIS

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: PROJECT NARRATIVE Music therapy has become a standard palliative care service in many pediatric and adult hospitals; however, a majority of music therapy research has focused on the use of music to improve psychosocial dimensions of health, without considering biological dimensions. This study builds on prior work examining the psychosocial mechanisms of action underlying an Active Music Engagement (AME) intervention, designed to help manage emotional distress and improve positive health outcomes in young children with cancer and parents, by examining its effects on biomarkers of stress and immune function. Findings will povide a more holistic understanding about how active music interventions work to mitigate cancer-related stress and its potential to improve immune function, with direct implications for the evidence-based use of music to improve health.

PI_NAMEs: ROBB, SHERI L (contact)

PROGRAM_OFFICER_NAME: KEHL, KAREN

PROJECT_TERMS: Acute;Acute Lymphocytic Leukemia;Address;Adult;Affect;Age;Analysis of Covariance;Area;attentional control;Behavior;Behavioral;biobehavior;Biological;Biological Markers;Blood;Blood specimen;burden of illness;cancer diagnosis;cancer therapy;care systems;Caregivers;Child;Childhood;Chronic Disease;Clinic Visits;clinical practice;Clinical Research;clinical translation;cytokine;design;Dimensions;Disease;Distress;Dose;Emotional;emotional distress;Environment;evidence base;experience;Funding;Glucocorticoids;Health;high risk;Hospitals;Hydrocortisone;hypothalamic-pituitary-adrenal axis;immune function;immunoregulation;improved;Individual;interest;Intervention;leukemia treatment;Malignant Childhood Neoplasm;Malignant Neoplasms;Measures;Mediating;Mediation;Mediator;Modeling;multidisciplinary;Music;Music Therapy;National Center for Complementary and Integrative Health;Oncology;Outcome;palliative;Palliative Care;Parents;Participant;Pediatric Oncology;Phase;Play;Population;primary caregiver;Production;psychologic;psychosocial;Quality of life;Randomized;Randomized, Controlled Trials;Relapse;response;Risk;Salivary;Sampling;Site;Sociology;Stress;stress symptom;Stressful Event;Symptoms;Target Populations;Testing;Therapeutic Studies;Time;translational study;traumatic stress;Treatment Failure;Work

PROJECT_TITLE: Biologic Mechanisms and Dosing of Active Music Engagement to Manage Acute Treatment Distress and Improve Health Outcomes in Young Children with Acute Lymphoblastic Leukemia and Parents


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Drug Abuse (NIDA only);Lung;Opioids;Pain Research;Patient Safety;Pediatric;Substance Misuse

ORG_CITY: IRVINE

ORG_NAME: NEUROPTICS, INC.

ORG_STATE: CA

PHR: PROJECT NARRATIVE Opioid-induced respiratory depression is a life-threatening concern that is preventable in patients undergoing surgery yet continues to be a major contributor to costly morbidity, mortality, length of hospital stay, and malpractice claims. NeurOptics is developing a pupillometry-based easy to use, bedside tool to predict postoperative respiratory depression in children in real-time. The perioperative use of this innovative and impactful technology will help clinicians to prevent respiratory depression, improve safety surgical pain management with opioids while reducing perioperative cost of care with optimal hospital resource utilization.

PI_NAMEs: OLIVER, JEFFREY WADE (contact);PRIVITERA, CLAUDIO ;SADHASIVAM, SENTHILKUMAR

PROGRAM_OFFICER_NAME: KOSTOV, YORDAN VALTCHOV

PROJECT_TERMS: Acceleration;Address;Adult;Adverse effects;Adverse event;adverse outcome;Agreement;American;Analgesics;Biological Markers;Breakthrough device;Cardiovascular system;care costs;Cessation of life;Child;Childhood;Classification;Clinical;Clinical Data;Clinical Research;Clinical Trials;cohort;Collaborations;commercialization;Computer software;cost;Data;Data Set;design;Development;Device or Instrument Development;Devices;Economic Burden;Enrollment;Feedback;Focus Groups;follow-up;Funding;graphical user interface;Health Care Costs;high risk;Hospitals;improved;innovation;Legal patent;Length of Stay;Licensing;Life;Malpractice;manufacture;Marketing;Measures;meetings;Monitor;Morbidity - disease rate;mortality;Nausea;novel;Operative Surgical Procedures;Opioid;opioid epidemic;opioid use;Outcome;Output;Overdose;Pain;Pain management;Patients;Pediatric Hospitals;Pediatric Surgical Procedures;Perioperative;Perioperative complication;Phase;Population;Postoperative Period;prediction algorithm;predictive modeling;prevent;Production;prototype;Public Health;Recommendation;Regulatory Pathway;Research;Resources;respiratory;Risk;risk prediction;Safety;Sedation procedure;Small Business Innovation Research Grant;socioeconomics;Statistical Methods;success;surgical pain;Technology;technology validation;Testing;Time;Tonsillectomy;tool;United States National Institutes of Health;Ventilatory Depression;Vomiting

PROJECT_TITLE: Development and Commercialization of a pupillometer to predict postoperative opioid-induced respiratory depression in children


NIH_SPENDING_CATS: Bioengineering;Neurosciences;Physical Injury - Accidents and Adverse Effects;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: DREXEL UNIVERSITY

PHR: This project is relevant for public health because understanding the role and function of the spinal circuits controlling sensorimotor integration and interlimb coordination in the mammalian spinal cord is a prerequisite for the systematic study of impaired locomotion due to a variety of syndromes. Additionally, it will establish a theoretical foundation for clinical research aiming to improve locomotor function following spinal cord injury and degenerative disorders.

PI_NAMEs: DANNER, SIMON MICHAEL (contact)

PROGRAM_OFFICER_NAME: DOPERALSKI, ADELE ELIZABETH

PROJECT_TERMS: Address;Anatomy;Animals;Behavioral;biomechanical model;Brain Stem;Clinical Research;Collaborations;Computer Models;connectome;Contralateral;Cutaneous;Degenerative Disorder;design;Elderly;Electrophysiology (science);Equilibrium;Excision;experimental study;Feedback;Fiber;Foundations;Future;Gait;Gene Delivery;Hindlimb;Impairment;improved;in vivo;Individual;insight;interdisciplinary approach;Interneurons;Ipsilateral;kinematics;Knowledge;Limb structure;Literature;Local Anesthetics;Locomotion;locomotor control;Methods;Modeling;Motor;Motor Activity;motor disorder;Motor Neurons;mouse genetics;mouse model;multidisciplinary;Mus;Muscle;Musculoskeletal;Musculoskeletal System;Mutant Strains Mice;neural;neural circuit;neural model;Neural Network Simulation;neuromechanism;Neurons;neuroregulation;novel;Pathway interactions;Pattern;Pattern Formation;Peripheral Nerve Stimulation;Phase;Phase Transition;Population;predictive modeling;Process;Public Health;Recovery;Reflex action;Rehabilitation therapy;Research Personnel;response;Rest;Role;Sensory;Signal Transduction;somatosensory;Speed;Spinal;Spinal Cord;Spinal cord injury;Surface;Syndrome;System;Testing;tool;transmission process;Virus;Wild Type Mouse;Work

PROJECT_TITLE: Spinal circuits for sensorimotor integration and interlimb coordination during locomotion

STUDY_SECTION: SMI

STUDY_SECTION_NAME: Sensorimotor Integration Study Section[SMI]


NIH_SPENDING_CATS: Cardiovascular

ORG_CITY: DALLAS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: PROJECT NARRATIVE The need for new discoveries in cardiovascular medicine has never been greater. To address this urgent issue, we are training the next generation of rigorously prepared cardiovascular investigators, both scientists and physicians. We provide a comprehensive program of education, mentoring, oversight, and feedback designed explicitly to help meet the cardiovascular healthcare needs of the future.

PI_NAMEs: HILL, JOSEPH A (contact)

PROGRAM_OFFICER_NAME: LIDMAN, KARIN FREDRIKSSON

PROJECT_TERMS: Cardiovascular system;Research;Training

PROJECT_TITLE: Training in Cardiovascular Research

STUDY_SECTION: NITM

STUDY_SECTION_NAME: NHLBI Institutional Training Mechanism Study Section[NITM(OA)]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Infectious Diseases;Prevention;Substance Misuse

ORG_NAME: BOSTON MEDICAL CENTER

PHR: PROJECT NARRATIVE The GRAIL trial will assess the efficacy of gabapentin versus placebo for improving HIV viral load suppression among people with HIV (PWH) and heavy alcohol use on ART as a “Treatment as Prevention” strategy. If shown to be effective, this will be a potent addition to the HIV prevention toolkit to address HIV transmission from PWH with heavy alcohol use in Russia, the US, and globally.

PI_NAMEs: LUNZE, KARSTEN ;SAMET, JEFFREY H. (contact)

PROGRAM_OFFICER_NAME: FALK, DANIEL EVAN

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Adherence;AIDS prevention;Alcohol abuse;alcohol abuse therapy;Alcohol consumption;Alcohol dependence;alcohol misuse;Alcoholic beverage heavy drinker;Alcohols;antiretroviral therapy;arm;brief intervention;Caring;Clinical;Clinical Trials;Controlled Clinical Trials;Country;Dose;Double-Blind Method;Drug usage;effective therapy;efficacy evaluation;efficacy testing;Epidemic;Europe;experience;gabapentin;Goals;Heavy Drinking;HIV;improved;Intervention;Knowledge;medication compliance;multidisciplinary;Naltrexone;opioid use disorder;Outcome;Pain;Participant;Patient Self-Report;Persons;Pharmaceutical Preparations;pharmacologic;Pharmacology Study;Placebo Control;Placebos;Population;prevent;Prevention;Prevention approach;Prevention strategy;primary outcome;Publishing;Randomized;randomized, clinical trials;reduced alcohol use;Regimen;relapse prevention;Research;Role;Russia;secondary outcome;sensory neuropathy;Severities;Strategic Planning;study population;substance use;Substance Use Disorder;syndemic;Testing;therapy adherence;transmission process;treatment as prevention;Treatment Effectiveness;United States National Institutes of Health;Viral Load result

PROJECT_TITLE: Gabapentin to Reduce Alcohol and Improve Viral Load Suppression - Promoting "Treatment as Prevention"


NIH_SPENDING_CATS: Cardiovascular;Rare Diseases

ORG_CITY: AUGUSTA

ORG_NAME: AUGUSTA UNIVERSITY

PHR: PROJECT NARRATIVE Abdominal aortic aneurysm (AAA) is a devastating disease carrying high morbidity and mortality due to fatal dissection and rupture, yet there have been no proven pharmaceutical treatments for AAA prevention and treatment. The proposed studies will address a new mechanism underlying AAA pathogenesis, involving the insufficient ubiquitin proteasome system (UPS) performance-mediated proteotoxicity governed by a novel signal cascade comprising a druggable upstream modulator (PDE10A) and a downstream effector (MYOCD) of gene transcription. Successful completion of the aims will inform therapeutic targeting strategies to combat AAA.

PI_NAMEs: LONG, XIAOCHUN  (contact);YAN, CHEN

PROGRAM_OFFICER_NAME: CATANIA, SELEN MURATOGLU

PROJECT_TERMS: abdominal aorta;Abdominal Aortic Aneurysm;Address;Angiotensin II;Aortic Aneurysm;Biochemical;Biological Assay;Blood Vessels;Cell Lineage;Cell Nucleus;cell type;combat;Complication;cost;Cyclic AMP;Cyclic AMP-Dependent Protein Kinases;Cyclic GMP;Cyclic Nucleotides;Development;Dilatation - action;Disease;Disease Progression;Dissection;Down-Regulation;Drug Targeting;Elastases;epigenome;Etiology;Family member;Functional disorder;Gatekeeping;Gene set enrichment analysis;Genes;Genetic Transcription;glycogen synthase kinase 3 beta;Human;human disease;Hydrolysis;Impairment;improved;In Vitro;Intervention;Knock-out;Knockout Mice;Mediating;misfolded protein;Modeling;Morbidity - disease rate;mortality;mouse model;Mouse Strains;multicatalytic endopeptidase complex;multiple omics;Mus;Muscle Contraction;Muscle Proteins;myocardin;novel;Operative Surgical Procedures;overexpression;Pathogenesis;Pathway Analysis;Pathway interactions;Performance;Pharmacologic Substance;Phenotype;phosphoric diester hydrolase;Play;prevent;Prevention;programs;Proteasome Inhibitor;protein degradation;protein expression;Proteins;proteostasis;proteotoxicity;Quality Control;Regulation;Reporter;Role;Rupture;Signal Transduction;Smooth Muscle Myocytes;System;Testing;therapeutic target;Time;Tissues;transcriptome;transcriptome sequencing;Transgenic Mice;Transgenic Organisms;Ubiquitin;Vascular Diseases;Vascular Smooth Muscle;virtual

PROJECT_TITLE: Vascular Smooth Muscle Protein Quality Control and Aortic Aneurysm Formation

STUDY_SECTION: AVI

STUDY_SECTION_NAME: Atherosclerosis and Vascular Inflammation Study Section[AVI]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Prostate Cancer;Urologic Diseases

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative  Our studies have significant translational impact because lineage plasticity is of central importance for understanding the molecular basis for resistance of castration-resistant prostate cancer (CRPC) to anti-androgen therapy. Such plasticity is likely to be responsible for the diverse phenotypic spectrum of CRPC, and in particular for the emergence of neuroendocrine differentiation, which is highly aggressive and lacks effective treatments. Our proposed analyses should identify novel targets for therapy as well as candidate drugs that inhibit lineage plasticity, which may ultimately lead to new therapeutic options for lethal metastatic prostate cancer.

PI_NAMEs: SHEN, MICHAEL M. (contact)

PROGRAM_OFFICER_NAME: HILDESHEIM, JEFFREY

PROJECT_TERMS: 3-Dimensional;abiraterone;Adenocarcinoma;Adenocarcinoma Cell;Adopted;Affect;Androgen Antagonists;androgen independent prostate cancer;Androgen Receptor;Anti-androgen Therapy;Biochemical;Biological Assay;Biological Models;bisulfite sequencing;candidate identification;candidate validation;cell type;Cells;Characteristics;ChIP-seq;Chromatin;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;Computer Analysis;Data;Development;Disease;DNA Methylation;DNA Modification Methylases;DNMT3a;drug candidate;effective therapy;enzalutamide;Epigenetic Process;epigenetic regulation;Epithelium;EZH2 gene;gain of function;Genetically Engineered Mouse;Genitourinary system;Genomics;Histones;Human;improved;in vivo;innovation;insight;interest;Investigation;Laboratories;Malignant neoplasm of prostate;Mediating;Metastatic Prostate Cancer;methylation pattern;Modeling;Modification;Molecular;Molecular Analysis;mouse model;Mus;Neuroendocrine Cell;neuroendocrine differentiation;Neuroendocrine Prostate Cancer;Neuroendocrine Tumors;Neurosecretory Systems;new therapeutic target;novel;novel therapeutics;Organoids;Pathology;Pathway interactions;Patients;Pattern;Pharmaceutical Preparations;pharmacologic;Phenotype;Play;Polycomb;Population;Population Heterogeneity;programs;Property;Prostate;Prostate Cancer therapy;Prostatic Neoplasms;receptor expression;recruit;Relapse;Resistance;Sampling;single cell ATAC-seq;single-cell RNA sequencing;Specific qualifier value;System;Systems Biology;therapeutic target;therapy resistant;transdifferentiation;Transitional Cell;translational impact;tumor;Validation;whole genome

PROJECT_TITLE: Investigating lineage plasticity in castration-resistant prostate cancer

STUDY_SECTION: CG

STUDY_SECTION_NAME: Cancer Genetics Study Section[CG]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Patient Safety;Precision Medicine;Prevention

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

PHR: PROJECT NARRATIVE The Genomic Risk Assessment Coordinating center for eMERGE (GRACE) will create infrastructure to implement and evaluate genomic risk assessments for common, complex diseases such as heart disease, and return these assessments to participants. GRACE will organize collaboration among eMERGE investigators, streamline data collection, and utilize cloud computing to enable large scale analyses of genomic data. GRACE will support the recruitment and genotyping of a 20,000 person cohort to determine the clinical impact of delivering genomic risk assessments, measure the uptake of risk reduction recommendations, and assess changes to clinical outcomes.

PI_NAMEs: LENNON, NIALL JOHN;PETERSON, JOSEPH F. (contact)

PROGRAM_OFFICER_NAME: ROWLEY, ROBB KENNETH

PROJECT_TERMS: Adult;All of Us Research Program;biobank;Case Report Form;Childhood;Clinical;clinical risk;clinical translation;clinically actionable;Cloud Computing;cohort;Collaborations;Communication;Communities;Complex;Computerized Medical Record;Contracts;Data;Data Analyses;Data Collection;data management;Data Science;data tools;Databases;Dedications;design;Development;Diagnosis;Disease;disease phenotype;disorder prevention;Effectiveness;Electronic Health Record;Electronic Medical Records and Genomics Network;Electronics;Evolution;experience;Family;Family health status;Feedback;Funding;Genome;genomic data;Genomic medicine;Genomics;Genotype;Heart Diseases;Home;improved;Individual;Informatics;Infrastructure;innovation;Institutional Review Boards;International;Intervention;Knowledge;Laboratories;Leadership;Manuscripts;Measures;member;Methods;Monitor;multi-ethnic;multidisciplinary;National Human Genome Research Institute;Nature;Outcome;Outcome Assessment;Participant;patient oriented;Patients;Persons;Phase;Phenotype;point of care;polygenic risk score;Population Heterogeneity;precision medicine;Principal Investigator;Process;Productivity;programs;Prospective Studies;Provider;Publishing;real world application;Recommendation;Recording of previous events;recruit;Reporting;repository;Research;Research Methodology;Research Personnel;Resources;Risk;Risk Assessment;Risk Factors;Risk Management;Risk Reduction;Role;Services;success;support network;tool;Translating;Universities;uptake;Validation;Vision;Visualization;Work

PROJECT_TITLE: The eMERGE Risk Assessment Network - Coordinating Center


NIH_SPENDING_CATS: Autoimmune Disease;Crohn's Disease;Digestive Diseases;Inflammatory Bowel Disease;Nutrition

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: PROJECT NARRATIVE Thousands of ~1-2 µm-long membrane extensions protrude from the top of each intestinal epithelial enterocyte to form the microvillus brush border, which increases the capacity of the epithelium to house digestive enzymes, transporters, and host defense molecules. Despite the importance of this host-environment interface to normal intestinal physiology, very few studies have addressed the biological pathways that regulate this structure and whether it contributes to intestinal pathologies where microvillus structure is disrupted, such as Crohn’s disease. The proposed studies will use mouse models, primary intestinal epithelial cell cultures, and human biopsy samples to address this knowledge gap, with the long-term goal of providing guidance on the design of therapeutics to restore epithelial function and promote mucosal healing in Crohn’s disease patients.

PI_NAMEs: VANDUSSEN, KELLI LYNN (contact)

PROGRAM_OFFICER_NAME: SENGER, STEFANIA

PROJECT_TERMS: Acute;Address;Adherent Culture;Affect;Aftercare;Agonist;Air;antagonist;Anti-Inflammatory Agents;Apical;Area;Binding;Biological;Biological Markers;Biopsy;Biopsy Specimen;Body Weight decreased;Brush Border;Cell Culture Techniques;Cell Physiology;cell type;cellular microvillus;Clinical;Colitis;Colon;Colon Injury;Crohn's disease;Crossbreeding;Data;Defect;design;Development;dextran sulfate sodium induced colitis;Diarrhea;dietary control;Digestion;Disease;Distal;Distant;Duodenum;Dyslipidemias;Enterocytes;Environment;Environmental Risk Factor;Enzymes;Epithelial Cells;Epithelium;Fatty acid glycerol esters;fatty acid metabolism;fatty acid oxidation;feeding;Future;gain of function;gene function;Goals;healing;Health;Hepatocyte;High Fat Diet;Histologic;Homeostasis;Host Defense;Human;Ileal Diseases;ileum;In Vitro;Individual;Inflammation;Inflammatory;Injury;Intestinal Diseases;intestinal epithelium;intestinal injury;Intestines;Knowledge;Length;Ligands;Link;Lipids;Liquid substance;loss of function;Mediating;Membrane;Metabolic;meter;Methods;Modeling;Molecular;monolayer;Morphology;mouse model;Mouse Strains;Mucin 1 protein;Mucous Membrane;Mus;novel;Nuclear Receptors;nutrient absorption;Outcome;overexpression;Pathologic;Pathology;Pathway Analysis;Pathway interactions;Patients;Peroxisome Proliferators;Phenotype;Physiological;Physiology;Pilot Projects;Poly I-C;PPAR alpha;Prediction of Response to Therapy;prevent;Property;protein expression;Refractory Disease;Regulation;Reporting;Risk;Role;scaffold;Signal Transduction;Site;Small Intestines;Sodium Dextran Sulfate;Structure;Surface;Testing;Therapeutic;tissue injury;Tissue Sample;Tissues;tool;transcriptome sequencing;transcriptomics;treatment risk;Villus

PROJECT_TITLE: Contributions of the enterocyte brush border to intestinal health and disease

STUDY_SECTION: DHMI

STUDY_SECTION_NAME: Digestive System Host Defense, Microbial Interactions and Immune and Inflammatory Disease Study Section[DHMI]


ORG_CITY: BAR HARBOR

ORG_NAME: JACKSON LABORATORY

ORG_STATE: ME

PHR: RELEVANCE TO PUBLIC HEALTH (PROJECT NARRATIVE) OVERALL The Center for Systems Neurogenetics of Addiction (CSNA) seeks to identify the biological relationships among the stages and patterns of cocaine addiction and behaviors that predict drug abuse. To uncover these relationships, we will make use of advanced mouse genetic tools that allow us to precisely and efficiently identify the genes related to addiction, and computational methods that enable holistic study of genes, biological molecules and behaviors. We will discover addiction-related genes, but we will also generate enabling resources and services for the addiction research community to unravel the complexity of addiction risk.

PI_NAMEs: CHESLER, ELISSA J (contact)

PROGRAM_OFFICER_NAME: LOSSIE, AMY C

PROJECT_TERMS: Acceleration;Acute;addiction;Address;advanced system;Animals;Awareness;Basic Science;Behavior;behavior prediction;Behavioral;Behavioral Mechanisms;behavioral phenotyping;biobank;biobehavior;Bioinformatics;Biological;Biological Models;Biology;career;Cocaine;Cocaine Dependence;cocaine related behaviors;cocaine self-administration;cocaine sensitization;Collaborations;Communities;Complex;Computational Science;Computing Methodologies;Core Facility;Data;Data Analyses;data dissemination;data integration;data resource;Data Set;Deposition;Dimensions;Disease;disease model;Diverse Workforce;Drug abuse;Drug Addiction;Drug Exposure;drug reinforcement;Drug Sensitization;Drug usage;Education and Outreach;Environmental Risk Factor;Etiology;Exhibits;Fostering;functional genomics;Funding;Future;gene discovery;Gene Expression;Generations;Genes;Genetic;genetic analysis;genetic approach;Genetic Engineering;Genetic Variation;Genome;genome editing;genomic data;Genomics;Genotype;Goals;Human;human disease;Human Genetics;Impulsivity;Inbred Strains Mice;Individual;Informatics;innovation;insight;Legal patent;Maps;Mediating;Methodology;Methods;model development;Modeling;Molecular;Molecular Profiling;mouse genetics;mouse model;Mouse Strains;Mus;Mutant Strains Mice;neurobiological mechanism;Neurobiology;neurogenetics;Neurosciences;novel;Pathologic;Pattern;Pharmaceutical Preparations;phenomics;Phenotype;Population;Population Genetics;pre-clinical;Pre-Clinical Model;Predisposition;Process;programs;Public Health;Quantitative Trait Loci;Recovery;Reproducibility;Research;Research Activity;Research Personnel;Research Project Grants;Research Support;resistant strain;Resource Informatics;Resources;response;Risk;Risk Taking;Role;Sample Size;Science;Self Administration;Services;Social Policies;stimulant use;substance use;Substance Use Disorder;Susceptibility Gene;System;Techniques;The Jackson Laboratory;Therapeutic Intervention;Therapeutic Research;tool;Training;Training and Education;trait;Validation;Variant;Work


NIH_SPENDING_CATS: Brain Disorders;Drug Abuse (NIDA only);Genetics;Neurosciences;Stimulant Use and Misuse;Substance Misuse

PROJECT_TERMS: addiction;Administrator;Award;Awareness;Behavioral;behavioral phenotyping;Biological;Biological Factors;Biological Models;career development;Collaborations;collaborative environment;Communication;Communities;Computational Biology;computing resources;data science infrastructure;data sharing;Decision Making;dimensional analysis;Dimensions;Education;Education and Outreach;education resources;Evaluation Research;experience;Fostering;Funding;Genetic;Genomics;Geography;Goals;High School Student;insight;Institution;Intellectual Property;Investments;knowledge base;Laboratories;Leadership;Letters;Logistics;Mediating;meetings;Methods;Mission;mouse model;multidisciplinary;Mus;neurogenetics;Neurosciences;North Carolina;novel;outreach;Pilot Projects;Population;Preparation;Program Reviews;programs;Publications;Recommendation;Reporting;Research;Research Personnel;Research Project Grants;Resource Sharing;Resources;Risk;Site;Standardization;stimulant abuse;stimulant dependence;success;synergism;System;Technology;The Jackson Laboratory;Training;Training and Education;Universities;Work

PROJECT_TITLE: Administrative Core