PROJECT_TERMS: Acids;Acute Promyelocytic Leukemia;Adipocytes;Adipose tissue;Affinity;Agonist;airway hyperresponsiveness;Allergic;analog;antagonist;Apoptosis;Area;Asthma;asthma exacerbation;asthma model;attenuation;Benzopyrans;Binding;Biological;Biological Availability;Body System;Body Weight;Brain;carbene;cardioprotection;CCL24 gene;Cell Death;Cell Physiology;Cell Proliferation;Cell Surface Receptors;Cells;chemical property;chemical synthesis;Chemicals;Chemotactic Factors;Chemotaxis;Chronic Disease;chronic neuropathic pain;chronic pain;Collaborations;Communication;Crystallography;cytokine;deprivation;design;Development;Diabetes Mellitus;diet-induced obesity;Digestive System Disorders;Disease;drug discovery;Drug Screening;Endocrine System Diseases;Energy-Generating Resources;Enzymes;eosinophil;Eosinophilia;Epidemic;extracellular;Family;Fasting;Fatty acid glycerol esters;Fatty Acids;Fatty Liver;Feedback;Fibrinolytic Agents;Flow Cytometry;Fluorescent Probes;Future;G-Protein-Coupled Receptors;Glucocorticoids;Glucose;glucose tolerance;Glycerol;Goals;GPR105 receptor;Heart failure;Hematopoietic;High Fat Diet;Homology Modeling;Human;Immune response;Immune system;improved;in vivo;Inflammation;Inflammatory Response;Insulin;insulin sensitivity;Intercalated Cell;Ion Channel;Islet Cell;Islets of Langerhans;Kidney;Knock-out;Knockout Mice;Laboratories;Laboratory Research;Leukemic Cell;Libraries;Ligands;Lipolysis;Lung;Malignant Neoplasms;MAPK8 gene;Mediating;Medicine;Metabolic;Microglia;Molecular Conformation;molecular dynamics;molecular modeling;molecular recognition;Molecular Structure;Mus;Muscle Cells;Mutagenesis;Nerve Degeneration;Nervous System;Neurodegenerative Disorders;Neurotransmitters;neutrophil;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutics;nucleotide receptor;Nucleotides;Obesity;P2X-receptor;Pain;pain signal;Pancreas;Pathway interactions;Peptide Hydrolases;Peripheral;Peroxisome Proliferator-Activated Receptors;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;pharmacologic;Physiological;Population;prevent;Production;Property;protein structure function;purinoceptor P2Y6;Pyrimidine Nucleotides;radioligand;receptor;recruit;Reporting;Research;Resistance;response;Ribose;Role;scaffold;Signal Pathway;Signal Transduction;Skeletal Muscle;small molecule;stem cell differentiation;Stress;Structure;Structure-Activity Relationship;subcutaneous;Synapses;System;systemic inflammatory response;Therapeutic;Therapeutic Intervention;therapeutic target;Tissues;tool;Uridine Diphosphate Sugars;Visceral;Wild Type Mouse

PROJECT_TITLE: Development of P2Y Receptor Ligands


ACTIVITY: ZIA

ADMINISTERING_IC: DK

ARRA_FUNDED: N

FUNDING_MECHANISM: INTRAMURAL RESEARCH

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Cancer;Chronic Pain;Eye Disease and Disorders of Vision;Neurosciences;Pain Research

PI_NAMEs: JACOBSON, KENNETH ALAN (contact)

PROJECT_TERMS: Adenine;Adenosine;Adenosine A2B Receptor;Adenosine Kinase;ADORA3 gene;Affinity;Agonist;antagonist;anti-cancer;Anti-glaucoma Agent;Anti-Inflammatory Agents;Anticonvulsants;Area;ATP-Binding Cassette Transporters;Binding;Binding Proteins;Biological;Brain;cancer cell;cancer immunotherapy;Cardiovascular system;Central Nervous System;cerebroprotection;chemical synthesis;Chemicals;chemotherapeutic agent;Chemotherapy-Oncologic Procedure;chronic constriction injury;Chronic Disease;chronic neuropathic pain;Clinical Trials;Collaborations;computerized;design;Development;Disease;disease model;drug action;drug development;Enzyme Inhibition;Event;Future;G-Protein-Coupled Receptors;Glaucoma;Heart;Hyperalgesia;Immune system;in silico;In Vitro;Inflammatory;inhibitor;interest;interleukin-23;Ischemia;Laboratories;Legal patent;Lesion;Licensing;Life;Ligands;Light;Lipids;Lung;Machine Learning;Malignant Neoplasms;Masks;Medical;Membrane;Modeling;Modification;Molecular;Molecular Conformation;molecular modeling;molecular recognition;Morphine;mouse model;Mus;nanomolar;Neurodegenerative Disorders;NF-kappa B;Normal Cell;novel;Nuclear Magnetic Resonance;nucleoside analog;Nucleosides;Nucleotides;Opioid;overexpression;Pain;Pathway interactions;Patients;Peripheral;Pharmaceutical Preparations;pharmacologic;Pharmacologic Substance;Phase III Clinical Trials;physical property;Positioning Attribute;positive allosteric modulator;preclinical development;preservation;prevent;Process;Prodrugs;programs;Proliferating;Protein Kinase C;Psoriasis;Public Health;Pulmonary Fibrosis;Purinergic P1 Receptors;rational design;receptor;Receptor Activation;Reporting;Research;Ribose;Roentgen Rays;Role;scaffold;screening;Side;side effect;Signal Pathway;Signal Transduction;Signal Transduction Pathway;Site;Skeletal Muscle;Skin;Source;Stress;stroke clinical trials;Structure;System;Technology;Therapeutic;therapeutic target;Therapeutic Uses;Thiophenes;three dimensional structure;tool;Topical application;translational medicine;translational potential;Traumatic Brain Injury;tumor;tumor microenvironment;Visceral pain;Wisconsin;Withdrawal;X-Ray Crystallography

PROJECT_TITLE: Development of Drugs Acting at Adenosine Receptors


NIH_SPENDING_CATS: Bioengineering

ORG_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

PROJECT_TERMS: Adenine;Adenosine;Adenosine A1 Receptor;ADORA3 gene;Affinity;Agonist;analog;antagonist;Astronomy;base;Binding;Binding Proteins;Binding Sites;California;Cardiovascular Diseases;Charge;chemical synthesis;Chemicals;Clinical;Collaborations;Complex;Computational Technique;Computer Models;Crystallography;Databases;design;Disease;Docking;Drug Design;drug development;Drug Kinetics;drug-like compound;Elements;extracellular;Family;G-Protein-Coupled Receptors;Homologous Gene;Homology Modeling;Human;Hydrophobicity;in silico;Inflammation;insight;Isoxazoles;kappa opioid receptors;lead optimization;Libraries;Ligands;Maps;Materia Medica;Measures;Membrane;Methods;Modeling;Molecular;molecular dynamics;molecular recognition;Mus;Mutagenesis;Niacinamide;novel;Nucleosides;Nucleotides;obesity treatment;Opioid Antagonist;Pain;Performance;piperidine;predictive modeling;Productivity;Protein Databases;Purinergic P1 Receptors;Purines;Purinoceptor;Pyrimidines;radioligand;Rattus;receptor;Reporting;Resolution;Retrieval;Ribose;Roentgen Rays;Role;scaffold;screening;Sequence Alignment;Series;Serotonin;Signal Transduction;small molecule;Structure;Structure-Activity Relationship;success;System;three-dimensional modeling;Universities;virtual;virtual library;virtual screening;Water;water conservation;X-Ray Crystallography

PROJECT_TITLE: Computer Modeling of G Protein-Coupled Receptors


NIH_SPENDING_CATS: Brain Disorders;Cardiovascular;Cerebrovascular;Heart Disease;Neurosciences;Pain Research;Stroke

PROJECT_TERMS: ABCB1 gene;ABCG2 gene;Action Potentials;Acute;addiction;Adenosine;Adenosine A3 Receptor;Affect;Agonist;analog;Animal Experiments;antagonist;ATP-Binding Cassette Transporters;Behavior Disorders;Binding;Binding Sites;Biological;Biological Process;Calcium ion;Calsequestrin;cancer therapy;Cardiac;Cardiac Myocytes;Cardiomyopathies;cardioprotection;Cardiotonic Agents;Cardiovascular system;Cations;Cavia;Cells;Central Nervous System;cerebroprotection;Chronic;Cocaine;Collaborations;Connecticut;Cryoelectron Microscopy;Data;design;Dopamine;dopamine transporter;drug action;drug development;Drug Kinetics;Dynamin;extend lifespan;extracellular;Goals;Guanine Nucleotides;Heart failure;heart function;Heart Hypertrophy;Human;Hydrolysis;in vivo;Industry;Infiltration;Inflammation;Inflammatory;inhibitor;inorganic phosphate;interest;Ion Channel;Ion Channel Gating;Ischemic Stroke;Learning;Licensing;Ligands;Lung;Macrophage;Mediating;Membrane Potentials;Memory;meter;Microglia;middle cerebral artery;Modeling;Molecular Conformation;Molecular Structure;monoamine;monocyte;Mus;Muscle Cells;Myeloid Cells;Naphthalene;neuroprotection;novel;novel strategies;Nucleosides;Nucleotidases;nucleotide analog;Nucleotides;Oral;Oral Administration;Oregon;overexpression;P2X-receptor;Pain management;Peripheral;Permeability;Pharmaceutical Preparations;Phenotype;phosphonate;Positioning Attribute;potassium ion;preference;Preparation;Privatization;Pump;radioligand;Rattus;receptor;Receptor Activation;Receptor Inhibition;Recovery;Regulation;Reporting;Resistance;Rest;Ribose;Role;Scanning;Sodium;sodium ion;stroke model;stroke recovery;stroke therapy;structural biology;Structure;Structure-Activity Relationship;symporter;System;Testing;Time;Tropanes;Universities;uptake;Vasodilator Agents;Ventricular

PROJECT_TITLE: Development of Drugs Acting at Ion Channels


PI_NAMEs: WESS, JURGEN  (contact)

PROJECT_TERMS: Agonist;Arrestin Beta 1;Arrestins;beta-arrestin;Binding;Clathrin;Clinical;clinically relevant;coated pit;Couples;Coupling;desensitization;extracellular;Family;G alpha q Protein;G-Protein-Coupled Receptors;Generations;Goals;GTP-Binding Proteins;Heterotrimeric GTP-Binding Proteins;In Vitro;in vivo;interest;Manuscripts;Mediating;member;Molecular;Molecular Conformation;Muscarinic Acetylcholine Receptor M3;Muscarinic M3 Receptor;mutant;Nature;Pharmaceutical Preparations;pharmacologic;Pharmacotherapy;Phosphorylation;Phosphotransferases;Physiology;Preparation;Process;Property;Protein Family;prototype;Publications;receptor;receptor function;recruit;Rhodopsin;Signal Transduction;Signaling Molecule;Site-Directed Mutagenesis;Structure;Work

PROJECT_TITLE: Molecular basis of G protein-coupled receptor function


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Complementary and Integrative Health;Emerging Infectious Diseases;Infectious Diseases;Natural Products

PI_NAMEs: BEWLEY, CAROLE  (contact)

PROJECT_TERMS: Acids;Adjuvant;Agriculture;Anabolism;Anti-Bacterial Agents;anti-cancer therapeutic;anti-tumor drug;Anti-viral Agents;Antibiotics;antimicrobial;arm;artificial intelligence model;Bacteria;Bacterial Infections;Basic Science;Binding;Biological;Biological Assay;C-terminal;Cell division;Cell Wall;cellular targeting;Chemical Structure;Circular Dichroism;Clinic;Clinical;Clinical Research;Collection;Communicable Diseases;Coupled;Cyclization;Cytoskeletal Proteins;Development;diene;Drug resistance;drug resistant pathogen;Ecology;Engineering;Enterococcus faecium;Enzymes;Exhibits;experimental study;Family;fungus;Genome;genome sequencing;Goals;Gossypium;Growth;Human;In Vitro;in vivo;Incidence;inhibitor;Interdisciplinary Study;Invertebrates;Legal patent;Ligase;Marine Invertebrates;marine natural product;Mass Spectrum Analysis;methicillin resistant Staphylococcus aureus;microbial;microbiome;microorganism;Mining;Molecular Conformation;Molecular Structure;N-terminal;Names;natural product inspired;Natural Products;Nature;NMR Spectroscopy;novel;novel antibiotic class;Nucleosides;Optical Rotation;Organism;Pathway interactions;Peptide Biosynthesis;peptide natural products;Peptides;polyketides;polypeptide;Production;Property;Protease Inhibitor;Research;Research Project Grants;Resistance;Resolution;Ribosomes;secondary metabolite;small molecule;Source;structural biology;Techniques;Therapeutic;Vancomycin resistant enterococcus;Vancomycin-resistant S. aureus;Variant;Veterinary Medicine;Vibrational Circular Dichroism;Work;X-Ray Crystallography

PROJECT_TITLE: Discovery, Structural Studies and Biosynthesis of Biologically Active Natural Products and Natural Product-Like Inhibitors


PI_NAMEs: APPELLA, DANIEL H (contact)

PROJECT_TERMS: Abbreviations;Acquired Immunodeficiency Syndrome;Affinity;Base Sequence;Binding;Biological;Bioterrorism;cancer cell;Cells;Chemicals;Chemistry;clinical diagnostics;Coupling;design;Detection;detection assay;Development;diagnostic technologies;Disease;disease diagnostic;Disease Marker;DNA Sequence;Enzyme Inhibitor Drugs;Goals;Growth;HIV;improved;interest;invention;Link;Manuscripts;Methods;MicroRNAs;Modification;Monitor;novel;nucleic acid detection;overexpression;pathogen;Patients;Penetration;Peptides;Plasma;Property;Publishing;receptor;Research;RNA;RNA Sequences;small molecule;small molecule inhibitor;Specificity;technology platform;tool;Work

PROJECT_TITLE: Chemically Modified Peptide Nucleic Acids


NIH_SPENDING_CATS: Genetics

PI_NAMEs: MIZUUCHI, KIYOSHI  (contact)

PROJECT_TERMS: Area;Attention;Bacterial Chromosomes;Bacteriophage mu;Behavior;Binding;Binding Proteins;Cells;Centromere;Chromosomes;Complex;CTPase;Distant;DNA;DNA Binding;DNA Integration;DNA Sequence;DNA-Binding Proteins;Eukaryota;F Factor;Gene Rearrangement;HIV;Homologous Gene;Investigation;Magnetism;Modeling;Monitor;mu opioid receptors;Nature;Phase;Physical condensation;Plasmids;Process;Prokaryotic Cells;Property;protein complex;Protein Family;Proteins;Reaction;Site;System;Transposase;viral DNA;Virus

PROJECT_TITLE: Study of the dynamics of higher order protein DNA complexes involved in variety of DNA transactions


PI_NAMEs: BUCHANAN, SUSAN  (contact)

PROJECT_TERMS: 2019-nCoV;Active Sites;Adopted;Affect;Affinity;Analytical Centrifugation;Binding;Biological;Biophysics;C-terminal;cancer type;CCCTC-binding factor;Cell Nucleus;Chromatin;Chromatin Structure;cohesin;Complex;design;dimer;Dimerization;Disease;DNA;DNA Binding Domain;DNA-Binding Proteins;drug development;Equilibrium;Event;Evolution;Exhibits;Genetic Transcription;Genome;Genomic DNA;Genomics;Histones;Human;inhibitor;interest;intermolecular interaction;Link;macromolecular assembly;Macromolecular Complexes;Measures;Mediating;Methods;Molecular Conformation;monomer;mutant;Mutate;Mutation;N-terminal;National Institute of Diabetes and Digestive and Kidney Diseases;Nuclear;Orthologous Gene;Peptide Hydrolases;Play;Polyproteins;Process;Property;Protease Inhibitor;Proteins;Protomer;Recombinants;Research;research and development;RNA;Role;sedimentation equilibrium;sedimentation velocity;Shapes;Site;Spermatogenesis;stoichiometry;Structure;Tail;Time;tool;Virus Replication;Work;Zinc Fingers

PROJECT_TITLE: Biophysics of Macromolecular Complexes


PI_NAMEs: YE, YIHONG  (contact)

PROJECT_TERMS: Address;Adopted;Affinity Chromatography;Anemia;Animals;Back;Basement membrane;Biogenesis;Cells;Client;cofactor;Collaborations;Collagen;Complex;Confocal Microscopy;coping;CRISPR screen;Cytosol;Data;Deposition;Development;Dislocations;Drosophila genus;Endoplasmic Reticulum;endoplasmic reticulum stress;Ensure;Enzymes;erythroid differentiation;Eukaryota;Fluorescence;genome-wide;Goals;Golgi Apparatus;Hemoglobin;Heterogeneity;HIV;Homeostasis;Human;human disease;Immune response;Immunologic Surveillance;Impairment;improved;Lysine;Lysosomes;Mammalian Cell;Mediating;Membrane;Membrane Proteins;Messenger RNA;misfolded protein;Modeling;Molecular;Molecular Chaperones;Molecular Conformation;multicatalytic endopeptidase complex;Multiprotein Complexes;Mus;Names;neuron development;novel;Pathogenesis;Pathway interactions;Play;polypeptide;Polyubiquitination;preservation;prevent;Production;Protein Biosynthesis;Protein Secretion;Protein translocation;Proteins;Proteolytic Processing;proteostasis;Quality Control;receptor;recruit;Research;Retrieval;Ribosomes;Role;Route;secretory protein;sensor;Site;Solubility;Sorting;stress reduction;stress tolerance;Substrate Specificity;Tail;trafficking;Translating;TRAPP transport protein particle;Triage;Ubiquitin;ubiquitin isopeptidase;ubiquitin ligase;Ubiquitination;Virus;Virus Diseases

PROJECT_TITLE: Mechanism of protein quality control at the endoplasmic reticulum


PI_NAMEs: YANG, WEI  (contact)

PROJECT_TERMS: Adopted;Affect;ATP Hydrolysis;ATP phosphohydrolase;Base Pair Mismatch;Base Pairing;Binding;Binding Proteins;blood-brain barrier crossing;C-terminal;CAG repeat;Cells;Chromatin Loop;Colorectal Cancer;Communication;Complex;Dactinomycin;daughter strand;Detection;Devices;Dissociation;DNA;DNA biosynthesis;DNA Structure;Drug Targeting;endonuclease;Escherichia coli;Eukaryota;exodeoxyribonuclease;Genome;Goals;helicase;Hereditary Nonpolyposis Colorectal Neoplasms;Homologous Gene;Human;inhibitor;insertion/deletion mutation;intercalation;interest;Length;macromolecule;Maintenance;Malignant Neoplasms;Manuscripts;Measures;Mediating;Methods;Methylation;Mismatch Repair;Molecular;Movement;Mutagenesis;nanomolar;Nucleotides;Pathologic;Patients;Persons;Power stroke;Predisposition;preservation;prevent;Process;Proteins;Publishing;recruit;repair function;Research;Resistance;Role;screening;Series;Signal Transduction;Specificity;SS DNA BP;stem;Structure;Surgical incisions;Time;Toxic effect;Trinucleotide Repeat Expansion;Trinucleotide Repeats;Visualization

PROJECT_TITLE: Structural and mechanistic studies Of DNA mismatch repair


PROJECT_TERMS: Adopted;Affinity;Antibiotics;Bacteria;beta barrel;Binding;Biochemical;Biogenesis;Biological Assay;Cells;Characteristics;Chloroplasts;Communication;Complex;Cryoelectron Microscopy;Cytoplasm;Detergents;Disease;experimental study;falls;Future;Gram-Negative Bacteria;Health;Homologous Gene;Human;human disease;In Vitro;Individual;insight;interest;Lateral;Lipid Bilayers;Lipids;Manuscripts;Membrane;membrane biogenesis;Membrane Proteins;Mitochondria;mitochondrial dysfunction;Molecular Chaperones;Molecular Conformation;Motion;nanodisk;nanomolar;Nature;Outer Mitochondrial Membrane;particle;Peptide Signal Sequences;Peptidoglycan;peptidomimetics;Peripheral;periplasm;Preparation;Protein Biosynthesis;Protein Export Pathway;Protein Import;Protein translocation;Proteins;Publications;Publishing;Research;Resolution;Role;Rotation;Science;Signal Transduction;small molecule inhibitor;Sorting;Streptococcus thermophilus;structural biology;Structure;Surface;targeted treatment;TOM translocase;Voltage-Dependent Anion Channel;Work;Writing

PROJECT_TITLE: structural characterization of bacterial secretion channels


PROJECT_TERMS: Active Sites;adduct;Archaea;Bacteria;Bacteriophage T7;base;Base Pair Mismatch;Benzopyrenes;Binding;Biochemical;Bypass;Catalysis;Cells;Chemical Agents;chemical bond;Chemicals;Chemistry;Complex;Conserved Sequence;Cryoelectron Microscopy;Dedications;DNA;DNA Binding;DNA biosynthesis;DNA Damage;DNA lesion;DNA Modification Process;DNA polymerase zeta;DNA replication fork;DNA-Directed DNA Polymerase;Elements;Enzymes;Escherichia coli;Exposure to;Family;Genetic Recombination;genome integrity;Genomics;Geometry;Goals;helicase;Human;Ions;Kinetics;Lesion;Life;member;Metals;Modification;Molecular;Multienzyme Complexes;Mutagenesis;mutant;Mutation;novel;Nucleotides;Polymerase;polymerization;Polymers;Positioning Attribute;Predisposition;Process;Proteins;Publishing;Pyrimidine Dimers;Reagent;repaired;Research;Series;Site;Structure;Translations;ultraviolet irradiation

PROJECT_TITLE: Structural and mechanistic studies of translesion DNA synthesis


PROJECT_TERMS: Active Sites;Antigen Receptors;artemis;B-Lymphocytes;Back;Biochemical;cell type;Cells;Chromatin Structure;Chromosome abnormality;Code;Collaborations;Complex;Cryoelectron Microscopy;Development;DNA;DNA Ligases;DNA polymerase mu;DNA Sequence;DNA Structure;DNA-dependent protein kinase;DNA-Directed DNA Polymerase;Epigenetic Process;Gene Rearrangement;Genes;Genetic Recombination;Goals;Growth;Immune system;Immunoglobulin Genes;Immunoglobulins;Invaded;J segment gene;Ligase;Ligation;Light;Lymphocyte;Lymphoid;Malignant - descriptor;Manuscripts;Mediating;Molecular;Molecular Conformation;Nature;Nonhomologous DNA End Joining;nuclease;overexpression;Paper;Pathway interactions;Peptide Signal Sequences;Phase;Process;Publishing;Receptor Gene;recombinase;Regulation;Series;Signal Transduction;Site;structural biology;Structure;T-Cell Receptor Genes;Transposase;V(D)J Recombination;Vertebrates;Work;Writing

PROJECT_TITLE: Structural and mechanistic studies of V(D)J recombination


PI_NAMEs: DYDA, FRED  (contact)

PROJECT_TERMS: 3-Dimensional;Adaptive Immune System;Adopted;Aedes;Affinity;Anopheles gambiae;Antibiotic Resistance;Architecture;Bacteria;Binding;Biological Assay;biophysical techniques;C-terminal;Cabbage - dietary;Cancer Control;cancer immunotherapy;casein kinase II;Cell Culture Techniques;Cell Physiology;Cell Therapy;cell type;Cells;chimeric antigen receptor T cells;Chiroptera;Chromosomes;Classification;Code;Complex;cost effective;Cryoelectron Microscopy;Crystallography;Culicidae;design;Development;dimer;Dimerization;DNA;DNA Binding Domain;DNA Transposons;DNase-I Footprinting;Elements;emerging antibiotic resistance;engineered stem cells;Engineering;Enzymes;Eukaryotic Cell;Evolution;Excision;experimental study;Future;Gene Rearrangement;gene therapy;Genes;Genetic;Genetic Engineering;Genome;genome editor;genomic locus;Genomics;Goals;Growth;Human;Human Engineering;In Vitro;Insect Control;Insecta;Insertional Mutagenesis;insight;interest;Investigation;Left;Length;Libraries;Location;Malaria;Mammals;Medical;member;Modification;Moths;Musca domestica;N-terminal;Nature;novel;Nucleic Acids;Paste substance;Pathogenesis;Phosphorylation;Phosphorylation Site;Plants;presynaptic;prevent;Process;programs;promoter;Proteins;Protomer;Publications;Publishing;Rationalization;recombinase;reconstitution;Research;Resolution;Roentgen Rays;Role;Site;Specificity;Structural Biochemistry;structural biology;Structure;System;Tertiary Protein Structure;Therapeutic;tool;transgenic insect;transmission process;Transposase;transposon/insertion element;vector;Work;Yellow Fever

PROJECT_TITLE: Structure and function of eukaryotic DNA transposases


PROJECT_TERMS: alpha Tubulin;Anti-Bacterial Agents;ATP phosphohydrolase;Bacteria;Binding;Binding Proteins;Biochemical;Biochemical Reaction;Biology;biophysical techniques;Biophysics;Cell division;cell preparation;Cells;Collaborations;Complex;Development;Diffusion;dimer;Dissociation;dynamic system;Escherichia coli;Event;Filament;Fluorescence;fluorescence microscope;Foundations;Glass;Goals;Guanosine Triphosphate;Homologous Gene;imaging study;In Vitro;in vivo;in vivo imaging;Individual;inhibitor;instrument;Kinetics;Knowledge;Label;Length;Lipid Bilayers;mathematical methods;Membrane;Mind;mind control;Modeling;Molecular;Molecular Conformation;molecular dynamics;Monitor;National Institute of Diabetes and Digestive and Kidney Diseases;Nature;novel;Pattern;Pattern Formation;Phase;Play;polymerization;Polymers;protein complex;Protein Family;Proteins;Reaction;reconstitution;Role;Scientist;self organization;Set protein;Slide;Surface;System;Techniques;Time

PROJECT_TITLE: Study of the mechanism of septum localization during bacterial cell division


PROJECT_TERMS: Anti-Bacterial Agents;Architecture;Area;ATP Hydrolysis;ATP phosphohydrolase;Bacteria;Bacterial Chromosomes;Behavior;Binding;Binding Proteins;Biochemical;Biological Models;Biophysical Process;biophysical techniques;Carpet;Cell division;Cell-Free System;Cells;Centromere;Chromosome Segregation;Complex;Coupling;CTPase;Cyanobacterium;Daughter;daughter cell;Development;Diffusion;Dissociation;DNA;DNA Binding;DNA biosynthesis;DNA Sequence;dynamic system;Ensure;Escherichia coli;Eukaryota;Event;F Factor;Family;Filament;Fluorescence;fluorescence microscope;Foundations;Generations;Genetic;Genome;Glass;Glycocalyx;Goals;Homologous Gene;Homologous Protein;imaging study;Immobilization;in vivo;in vivo imaging;Individual;Inherited;instrument;Kinetics;Knowledge;Label;Learning;Length;mathematical methods;Mitotic;Modeling;Molecular;Molecular Conformation;Monitor;Motion;novel;Organelles;plasmid DNA;Plasmids;Polymers;Positioning Attribute;Process;Prokaryotic Cells;protein distribution;Protein Dynamics;Protein Family;Proteins;Reaction;reconstitution;segregation;Set protein;Slide;Streptococcus pyogenes;Surface;System;Techniques;Time;Transportation

PROJECT_TITLE: Study of the mechanism of bacterial chromosome partitioning systems


NIH_SPENDING_CATS: Biotechnology;Genetics

PI_NAMEs: GELLERT, MARTIN F. (contact)

PROJECT_TERMS: Adaptive Immune System;Binding;Biochemical;C-terminal;Chordata;Chromatin;cofactor;Complex;Cryoelectron Microscopy;DNA;DNA Repair;DNA-dependent protein kinase;Ephrin-A5;Eukaryota;Exonuclease;Genes;Genetic Recombination;histone modification;Histones;homologous recombination;Human;Immunoglobulins;Lysine;Methylation;Multiprotein Complexes;Nonhomologous DNA End Joining;Process;protein complex;protein structure;Proteins;Publications;Reporting;Resolution;Role;Shark;Site;Structure;T-Cell Receptor Genes;V(D)J Recombination;Work

PROJECT_TITLE: Structural studies of proteins involved in DNA repair and recombination


NIH_SPENDING_CATS: Genetics;HIV/AIDS;Infectious Diseases

PI_NAMEs: CRAIGIE, ROBERT  (contact)

PROJECT_TERMS: Active Sites;Affect;Amides;Amino Acids;Anti-viral Therapy;Binding;Biochemical;biophysical analysis;C-terminal;Cell Culture Techniques;Cell Nucleus;Cells;Clinical;Collaborations;Complex;Consumption;Cryoelectron Microscopy;Cytoplasm;Data Analyses;Data Collection;density;design;Disease;Distal;DNA;DNA biosynthesis;DNA Integration;Drug Combinations;Drug resistance;Drug Targeting;ds-DNA;Enzymes;Exhibits;Filtration;Genome;Goals;HIV;HIV Integrase;HIV-1;HIV-1 integrase;Ice;improved;In Vitro;in vitro activity;in vivo;Individual;Infection;inhibitor;inorganic phosphate;Integrase;Integrase Inhibitors;Length;Maps;Mediating;methyl group;Modeling;Molecular;mutant;Mutate;Mutation;Nitrogen;novel drug class;Nucleoproteins;Nucleotides;Pathway interactions;Pharmaceutical Preparations;Positioning Attribute;preference;Property;Proteins;Protomer;Publishing;Reaction;reconstitution;Resistance;Resistance development;resistance mutation;Resolution;Retroviridae;RNA-Directed DNA Polymerase;Role;Sodium Chloride;Structure;Synapses;Tail;Testing;Time;Vertebral column;Vial device;Viral;viral DNA;Viral Genome;Viral Proteins;viral RNA;Virus;Virus Integration;Work

PROJECT_TITLE: Studies of nucleoprotein complexes involved in retroviral DNA integration


NIH_SPENDING_CATS: Cancer;Clinical Research;Digestive Diseases;Genetics;Pancreatic Cancer;Rare Diseases

PI_NAMEs: JHA, SMITA  (contact)

PROJECT_TERMS: adenoma;adverse outcome;Appearance;Biological Assay;Blood;bone;Calcium;Catheters;CCND1 gene;CDK6-associated protein p18;Clinical;Collaborations;Craniosynostosis;Cyclin D1;demineralization;Diagnosis;Disease;Endocrine Gland Neoplasms;Endocrine Glands;Etiology;Excision;exome sequencing;Face;Familial hypocalciuric hypercalcemia;Family;Fracture;Frequencies;gain of function mutation;GCM2 gene;Genes;Genetic Counseling;Genotype;Germ-Line Mutation;Gland;Growth;hearing impairment;Hyperparathyroidism;Hypoparathyroidism;Image;Impairment;indexing;Infarction;Inherited;interest;ionization;Jaw;Kidney Calculi;kinase inhibitor;Low Prevalence;malignant parathyroid gland tumor;Malocclusion;Measurement;Mediastinal;Medical Records;men;Metaphyseal chondrodysplasia;Modeling;Multiple Endocrine Neoplasia Type 1;Mutate;Mutation;Neck;neuromuscular;operation;Operative Surgical Procedures;optic nerve disorder;Osteopenia;Other Genetics;Parathyroid Adenoma;Parathyroid gland;Parathyroid Neoplasms;Parathyroidectomy;Pathologic;Patients;Pharmaceutical Preparations;Phenotype;Predisposition;proband;Process;Recurrence;Recurrent Laryngeal Nerve;Refractory;Repeat Surgery;Serum;Severities;Signs and Symptoms;skeletal;skills;Structure;success;Syndrome;Testing;Tissues;tumor;tumorigenesis;United States National Institutes of Health;Variant;Work

PROJECT_TITLE: Hyperparathyroidism -- Etiology, Diagnosis and Treatment


NIH_SPENDING_CATS: Biomedical Imaging;Clinical Research;Genetics;Rare Diseases

PI_NAMEs: SIMONDS, WILLIAM F (contact)

PROJECT_TERMS: 1q25;Adult;Affect;Amino Acids;autosome;Bilateral;Biochemical;Blood Tests;Calcium-Sensing Receptors;cell growth;Chromosome 1;Chromosome Arm;Clinical;clinical center;clinical investigation;Clinical Research;Critical Pathways;Cystic kidney;Discipline of Nuclear Medicine;Disease;Family;gain of function mutation;GCM2 gene;gene conservation;Gene Mutation;Genes;Genetic;Genotype;Germ Lines;Germ-Line Mutation;Goals;Heterozygote;Human Subject Research;Hyperparathyroidism;Hyperparathyroidism-jaw tumor syndrome;Image;Impairment;Individual;individual patient;Inherited;insight;International;Jaw;Kidney Neoplasms;kindred;Leukocytes;Link;loss of function mutation;malignant parathyroid gland tumor;member;MEN1 gene;Metabolic Diseases;Minority;MRI Scans;Mutation;Mutation Analysis;Names;Nature;Neoplasms;Patient Admission;Patients;Penetrance;peripheral blood;Phenotype;Predisposition;Proliferating;protein function;Proteins;Protocols documentation;Qualifying;Receptor Gene;Research Personnel;Roentgen Rays;Signal Transduction;Site;Solid;Syndrome;Testing;trait;transmission process;tumor;Tumor-Suppressor Gene Inactivation;United States National Institutes of Health;Urine;Visit;X-Ray Computed Tomography

PROJECT_TITLE: Clinical Investigation of FIHP, Parathyroid Cancer & the HPT-JT Syndrome


PI_NAMEs: WEINSTEIN, LEE  (contact)

PROJECT_TERMS: Adult;Age;Alleles;Autoimmune Diseases;autosome;Binding;Blocking Antibodies;Brain;calcification;Calcium;Cell Surface Receptors;Central Nervous System;Characteristics;Chondrocytes;Chromogranin A;Clinical;clinical investigation;clinical phenotype;Congenital Disorders;Cyclic AMP;Defect;Deletion Mutation;Development;Disease;DNA Methylation;DNA Sequence Alteration;Elements;Energy Metabolism;Epiphysial cartilage;Exons;Fathers;gene product;Generations;Genes;Genetic;Genetic Transcription;Germ Lines;glucose metabolism;GNAS gene;Goals;Gonadotropins;Growth;Gs alpha mutations;Hereditary Disease;Heterotopic Ossification;Heterotrimeric GTP-Binding Proteins;Heterozygote;histone methylation;hormone resistance;hormone sensitivity;Hormones;Human;Hypercalcemia;Hyperparathyroidism;Hypothalamic structure;implantation;imprint;Inherited;Insulin Resistance;Invaded;Journals;Kidney;Knock-out;Knockout Mice;Lesion;Link;Medicine;Messenger RNA;Metabolic;Modeling;Molecular;Morbid Obesity;Mothers;mouse model;Mus;Mutate;Mutation;neurobehavioral;Neurosecretory Systems;New England;Obesity;Operative Surgical Procedures;Osteoblasts;overexpression;Paper;Parathyroid Neoplasms;paternal imprint;Pathogenesis;Patients;Physiologic Ossification;Progressive osseous heteroplasia;promoter;Protein Isoforms;Proteins;Proximal Kidney Tubules;Pseudohypoparathyroidism;Pseudopseudohypoparathyroidism;PTH gene;Publishing;receptor;Reporting;Resistance;Resistance development;response;Second Messenger Systems;sex;Signal Pathway;Signaling Molecule;Skin;soft tissue;Somatotropin-Releasing Hormone;subcutaneous;Thyrotropin;Tissues;transmission process;United States National Institutes of Health;virtual;Vitamin D;Vitamin D Analog

PROJECT_TITLE: Studies Of Pseudohypoparathyroidism And Related Disorders


NIH_SPENDING_CATS: Genetics;Neurosciences

PROJECT_TERMS: Acylation;Alternative Splicing;Behavioral;Binding;Binding Proteins;Bioinformatics;Biological Models;Biology;Brain;Cell Line;Cell membrane;Cell Nucleus;Complex;Cytosol;Development;Enzymes;extracellular;Family;Gene Modified;genetic regulatory protein;genomic data;Germ Lines;GNB5 gene;Goals;GTP-Binding Proteins;Guanine Nucleotides;Heterodimerization;Human;Ion Channel;loss of function;mammalian genome;Membrane;Modeling;Molecular;Mus;Mutation;neural;Neuroanatomy;Neuroendocrine Cell;Neurons;Neurosecretory Systems;Pattern;Physiology;Property;protein complex;Protein Isoforms;Proteins;public database;receptor;receptor coupling;Research Project Grants;Retinal Photoreceptors;RGS Proteins;Rodent;Role;Signal Transduction;Signaling Protein;Stimulus;Structure;System;Transcript;Transducers;Work

PROJECT_TITLE: Mechanism of G Protein Beta5/ R7-RGS Protein/ R7BP Complex Signal Transduction


NIH_SPENDING_CATS: Digestive Diseases;Genetics;Liver Disease;Neurosciences;Nutrition;Obesity;Pediatric;Rare Diseases

PROJECT_TERMS: Adipocytes;Adipose tissue;Adrenergic Agonists;Alleles;Birth;Bone Marrow;Brain;Brown Fat;Cell Cycle;Cells;Central Nervous System;Chromogranin A;Chronic;Collaborations;Complex;Couples;Critical Pathways;Cyclic AMP;Cyclin-Dependent Kinases;Cyclins;Data;Development;Disease;Distal;Edema;Embryo;Endocrine;Energy Metabolism;Exons;Feedback;Female;Fibrous Dysplasia;gene product;Genes;Genetic Recombination;Germ Lines;Germ-Line Mutation;glucagon-like peptide 1;glucose metabolism;GNAS gene;Gonadal structure;Gs alpha mutations;GTP-Binding Protein alpha Subunits;Hepatocyte;Heterozygote;Homing;Homozygote;hormone resistance;Hormones;Human;Hypertriglyceridemia;Hypothalamic structure;imprint;in vivo;Individual;Inflammation;Inherited;Insulin;Insulin Resistance;islet;Islet Cell;Islets of Langerhans;Knock-in Mouse;Knock-out;Knockout Mice;Laboratories;Liver;LoxP-flanked allele;Lymphocyte;Lymphocyte Biology;male;McCune-Albright Syndrome;Mediating;Metabolic;Metabolic Activation;metabolic phenotype;metabolic rate;Metastatic Neoplasm to the Liver;Methylation;Modeling;Morbid Obesity;Mothers;mouse model;Mus;mutant;Mutation;Nephrons;neural circuit;Neurosecretory Systems;Nucleic Acid Regulatory Sequences;Obesity;offspring;Osteogenesis;overexpression;Pancreatic Endocrine Carcinoma;Partner in relationship;Patients;Perinatal;Phenotype;Phosphotransferases;Physiology;Pituitary Gland;Placenta;Play;postnatal period;Primary carcinoma of the liver cells;Production;promoter;Protein Isoforms;Proteins;Proximal Kidney Tubules;Pseudohypoparathyroidism;PTH gene;receptor;Receptors, Adrenergic, beta-3;Regulation;Renal function;Renin;Reporting;RNA Splicing;Role;Secondary to;Signal Transduction;Site;Study models;subcutaneous;suckling;Sympathetic Nervous System;Thinness;Thyroid Gland;Tissues;Trans-Activators;Transcript;Transgenic Organisms;United States National Institutes of Health;Up-Regulation;urinary;virtual;WNT Signaling Pathway

PROJECT_TITLE: Role of the Gnas Gene in Metabolic Regulation


PROJECT_TERMS: Acute;Agonist;Alleles;Area;Beta Cell;Blood Pressure;Body Composition;Body Weight;Brain region;Brown Fat;cardiovascular effects;Cardiovascular system;Cell Physiology;cell type;Cells;Central Nervous System;Chemistry;comparison control;Corticotropin;Corticotropin-Releasing Hormone;Couples;Cyclic AMP;Defect;Development;Diabetes Mellitus;Diet;diet-induced obesity;Disease;Eating;energy balance;Energy Metabolism;Enterobacteria phage P1 Cre recombinase;Exons;Female;Food Energy;Food Intake Regulation;Generations;Genes;Genetic Recombination;Germ-Line Mutation;Glucose;Glucose Intolerance;glucose metabolism;glucose tolerance;Gs alpha mutations;GTP-Binding Protein alpha Subunits;GTP-Binding Proteins;Heart Rate;Heterozygote;High Fat Diet;Hormones;Horns;Human;Hyperglycemia;Hyperlipidemia;Hypertension;Hypertriglyceridemia;Hypothalamic structure;Impairment;imprint;improved;In Situ Hybridization;Injections;Insulin;Insulin Resistance;Knock-out;Knockout Mice;Leptin;Leptin resistance;Lipids;loss of function mutation;LoxP-flanked allele;male;Malignant Neoplasms;Measurement;Measures;Mediating;Melanocortin 4 Receptor;Melanocortin 4 receptor mutation;Metabolic;metabolic phenotype;metabolic rate;Metabolism;Middle Hypothalamus;Morbid Obesity;mouse model;Mus;mutant;Mutation;Nerve;nestin protein;Neurons;novel therapeutics;Obesity;Organ Weight;paraventricular nucleus;Parents;Partner in relationship;Pathway interactions;Patients;Phenotype;Physiological;Play;Population;Prevalence;Pro-Opiomelanocortin;promoter;Pseudohypoparathyroidism;receptor;reduced food intake;Regulation;Resistance;response;Role;Serum;Signal Pathway;Signal Transduction;Site;Spinal Cord;Structure of beta Cell of islet;Sympathetic Nervous System;System;Testing;Therapeutic Agents;Thermogenesis;Tissues;Transgenes;Transgenic Organisms;uncoupling protein 1;Virus

PROJECT_TITLE: Role of Gs-alpha in central regulation of energy and glucose metabolism


NIH_SPENDING_CATS: Genetics;Nutrition;Obesity

PROJECT_TERMS: Acute;Adipocytes;adipokines;adiponectin;Adipose tissue;Adrenergic Agents;Adrenergic Agonists;Affect;Alleles;beta-adrenergic receptor;Body fat;Body Temperature;Body Weight;Brown Fat;Catecholamines;Cell Differentiation process;Cells;Central Nervous System;Coupled;Cyclic AMP;Diet;Embryo;Energy Metabolism;Enterobacteria phage P1 Cre recombinase;Environment;Exons;Fatty acid glycerol esters;fatty acid-binding proteins;Fibroblasts;Functional disorder;gene induction;Genes;Genetic Recombination;Germ Lines;glucose metabolism;glucose tolerance;Growth;Gs alpha mutations;GTP-Binding Proteins;Heart;Heterozygote;High Fat Diet;Histologic;Human;Hypoglycemia;Impairment;improved;In Vitro;in vivo;Insulin Resistance;insulin sensitivity;Insulin-Like Growth Factor I;Knock-out;Lead;lipid biosynthesis;lipid metabolism;Lipids;Lipolysis;Liver;LoxP-flanked allele;Mediating;Metabolic;Metabolic Activation;Modeling;Molecular;Morbid Obesity;Mus;Muscle;Obesity;Partner in relationship;Pathway interactions;Pattern;Peripheral;Phenotype;Production;programs;Receptors, Adrenergic, beta-3;Regulation;response;Role;Signal Pathway;Site;Skeletal Muscle;Sympathetic Nervous System;Thermogenesis;Thinness;Tissues;Transgenic Mice;uncoupling protein 1;Urine;Weight Gain

PROJECT_TITLE: Role of Gs-alpha in regulation of adipose tissue growth and function


NIH_SPENDING_CATS: Diabetes;Genetics;Nutrition

PROJECT_TERMS: adenylate kinase;Adipose tissue;Adrenergic Agents;Aerobic;Affect;Aging;analog;Area;Atrophic;beta-adrenergic receptor;Body Composition;Body Weight;Calories;Chemistry;Chronic;Cyclic AMP;Diet;Dissociation;Eating;energy balance;Energy consumption;Energy Metabolism;Enterobacteria phage P1 Cre recombinase;Exons;Fiber;Food Energy;Genetic Recombination;Genetic Transcription;Glucose;Glucose Clamp;glucose metabolism;glucose tolerance;glucose uptake;Growth;GTP-Binding Proteins;High Fat Diet;Hyperinsulinism;Hypoglycemia;Impairment;Insulin;Insulin Resistance;insulin secretion;Kinetics;Knock-out;LoxP-flanked allele;Metabolic;Metabolism;Mitochondria;Modeling;Mus;Muscle;Muscle Fibers;Muscular Atrophy;Myocardium;Myosin Heavy Chains;Partner in relationship;Pathway interactions;Phenotype;Play;Prediabetes syndrome;Production;promoter;Property;receptor;reduced muscle mass;Regulation;response;Role;Serum;Signal Transduction;Site;Skeletal Muscle;skeletal muscle metabolism;Sympathetic Nervous System;Testing;Thermogenesis;transcription factor;Transgenic Mice;Troponin;Wasting Syndrome

PROJECT_TITLE: Role of Gs-alpha in regulation of skeletal muscle metabolism


PROJECT_TERMS: Address;Adult;Alpha Cell;Apoptosis;Architecture;Beta Cell;Birth;Body Weight;CCND2 gene;cell growth;Cell Line;Cell Physiology;Cell Proliferation;Cells;Cyclic AMP;Development;Diabetes Mellitus;Duct (organ) structure;Enterobacteria phage P1 Cre recombinase;Exocrine pancreas;Exons;experimental study;Functional disorder;Genes;Genetic Recombination;Glucagon;glucagon-like peptide 1;Glucose;Glucose Intolerance;Growth;Hyperglycemia;impaired glucose tolerance;in vivo;incretin hormone;Insulin;Insulin deficiency;insulin sensitivity;IRS2 gene;islet;Islets of Langerhans;Life;LoxP-flanked allele;Malabsorption Syndromes;Mediating;mouse model;Mus;Mutation;pancreatic juice;Partner in relationship;postnatal;Proliferating;promoter;Rattus;Regulation;Role;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Site;Structure of alpha Cell of islet;Therapeutic;Transgenic Mice

PROJECT_TITLE: Role of Gs-alpha in pancreatic islet cell growth and function


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cardiovascular;Childhood Obesity;Clinical Research;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Pediatric;Prevention;Primary Immunodeficiencies;Racial and Ethnic Minority Health Research;Rare Diseases;Social Determinants of Health

PI_NAMEs: SUMNER, ANNE  (contact)

PROJECT_TERMS: Adult;Affect;Africa;Africa South of the Sahara;African;African American population;African ancestry;Age;allostatic load;American;Area;Authorization documentation;Beta Cell;Biological Assay;Black Populations;Body fat;Body Image;Body mass index;Body Size;Cardiometabolic Disease;cardiometabolic risk;cardiometabolism;Caring;Cell Physiology;Child;clinical practice;cohort;Collaborations;Data;design;Detection;detection sensitivity;Development;Diabetes Mellitus;Diagnosis;Diagnostic;diagnostic biomarker;Diagnostic tests;Diagnostics Research;Discrimination;Disease;Early Intervention;Education;Emigrations;Enrollment;epidemiology study;Equation;Equilibrium;Etiology;Exclusion;Exercise;expectation;Failure;fasting plasma glucose;Fructosamine;Genetic study;Glucose;glucose tolerance;Glucosephosphate Dehydrogenase Deficiency;glycosylated serum albumin;Goals;Health;Health behavior;heart disease risk;Heart Diseases;Heterogeneity;High Density Lipoproteins;Hyperglycemia;Immigrant;Immigration;improved;improved outcome;insight;Insulin Resistance;International;Investigation;Investments;Journals;Life;Low income;Maintenance;Measures;Medical Research;Metabolic stress;Methods;migration;National Human Genome Research Institute;Natural History;Non obese;novel diagnostics;Obesity;OGTT;Patient Care;perceived stress;Performance;Persons;Physiological;Pittsburgh Sleep Quality Index;Population;power analysis;Prediabetes syndrome;preference;preventive intervention;Protocols documentation;psychosocial;Public Health;Publications;Publishing;Race;Recommendation;Reduce health disparities;Refugees;Reproducibility;Research;research clinical testing;Research Design;Resource Allocation;Risk Factors;screening;Sleep;sleep quality;social determinants;South Africa;Spouses;Stress;sugar;Testing;tool;trait;Triglycerides;United States;Universities;validation studies;willingness;Work

PROJECT_TITLE: Diabetes and Heart Disease Risk in Blacks


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics;Neurosciences

PI_NAMEs: FORREST, DOUGLAS  (contact)

PROJECT_TERMS: Address;Auditory;Auditory system;Binding Sites;Biological Models;Brain;Brain region;Cell Differentiation process;Cell Lineage;Cell Separation;cell type;Cells;Central Nervous System;Chromatin;Clinic;Cochlea;Collaborations;Cone;Defect;Development;developmental disease;Disease;Epilepsy;experimental study;Eye Movements;Functional disorder;gain of function;ganglion cell;Gene Activation;Gene Expression;Gene Mutation;gene network;Generations;Genes;genetic analysis;genetic approach;Genetic Models;Genetic Transcription;Genomics;Goals;Head Movements;Hormones;Human;human disease;Impairment;insight;Intellectual functioning disability;Interneurons;Knock-in;Ligands;Light;loss of function;Mammalian Genetics;Mammals;Mediating;Modeling;Molecular Analysis;Morphology;Mutation;Nervous System;neural;Neurodegenerative Disorders;neurodevelopment;neurogenesis;Neuronal Differentiation;Neurons;next generation sequencing;novel;Nuclear Orphan Receptor;Nuclear Receptors;Optic Nerve;Organ;Orphan;osteoprotective;Pathway interactions;Pattern;Photoreceptors;Physiological;precursor cell;Predisposition;Procedures;Process;Protein Isoforms;receptor;receptor function;Receptor Gene;Regulation;Reporting;Retina;Retinal Cone;retinal progenitor cell;Retinoids;Rod;Role;Seizures;Sensory;sensory input;sensory system;Spinal Cord;stem cells;superior colliculus Corpora quadrigemina;System;Testing;Tissues;transcription factor;transmission process;Undifferentiated;Universities;Vertebrate Photoreceptors;Vision;visual information;Visual Pathways

PROJECT_TITLE: Orphan nuclear receptors and mammalian development


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics;Human Genome;Neurosciences

PROJECT_TERMS: Address;Affinity Chromatography;Apoptosis;Apoptotic;Binding Sites;Biological Models;Blood Circulation;Cell Death;Cell membrane;cell type;Cells;Chromatin;chromatin modification;Circulation;cofactor;color detection;Color Visions;Cone;Cone dystrophy;Cre driver;Defect;Development;developmental disease;differential expression;Endocrine system;Enzymes;Exposure to;Functional disorder;Gene Duplication;Gene Expression Regulation;gene network;Generations;Genes;Genetic;Genetic Models;Genomic approach;Genomics;Goals;Hormonal;Human;Impairment;insight;Investigation;Iodide Peroxidase;Knowledge;Light;Link;Maintenance;Mammalian Genetics;Mediating;Membrane Transport Proteins;Modeling;Monitor;mouse model;Mutation;next generation sequencing;novel;novel marker;Opsin;Pathway interactions;Photoreceptors;Physiological;Population;Predisposition;prevent;Process;Protein Isoforms;receptor;Regulation;Resolution;response;Retina;Retinal Cone;Retinal Degeneration;Retinal Diseases;Role;single cell sequencing;System;Techniques;Testing;THRB gene;Thyroid Diseases;Thyroid Function Tests;Thyroid Hormone Receptor;Thyroid Hormone Receptor Gene;Thyroid Hormones;Time;Tissues;transcription factor;transcriptome;transcriptome sequencing;uptake;Vision;Visual System

PROJECT_TITLE: Functions of thyroid hormone in retinal development


NIH_SPENDING_CATS: Biotechnology;Genetics;Neurosciences

PROJECT_TERMS: Address;Adrenal Cortex;Adrenal Glands;Adult;Age;Aging;Anterior Pituitary Gland;Auditory system;Binding;Binding Sites;Biological Process;Brain;cell cortex;Cell Differentiation process;Cell membrane;Cell Physiology;cell type;Cells;Chromatin;chromatin modification;Circulation;Clinical;Cochlea;cochlear development;Cre driver;Development;differential expression;Disease;Endocrine;Endocrine Glands;Endocrine system;Enhancers;Enzymes;Event;Fetus;Functional disorder;Gene Expression;Gene Expression Profile;Gene Expression Regulation;Genes;Genetic;genetic manipulation;Genetic Models;Genetic study;Genetic Transcription;Genomic approach;Genomic DNA;Genomics;Hearing;Homeostasis;Hormones;Human;Infant;Iodide Peroxidase;Kidney;Ligands;Liver;Lung;Mediating;Membrane Transport Proteins;Metabolic;Molecular;Mus;Mutation;novel;Organ;Pattern;Pituitary Gland;pituitary thyroid axis;Population;Positioning Attribute;Presbycusis;Production;promoter;Protein Isoforms;receptor;receptor binding;receptor function;Receptor Gene;Resistance;response;Retina;Retinal Cone;Role;Sensory;sexual dimorphism;Site;Specificity;Syndrome;System;Testing;Testis;THRA gene;THRB gene;Thyroid Diseases;Thyroid Function Tests;Thyroid Gland;Thyroid Hormone Receptor;Thyroid Hormones;Thyrotropin;Tissues;transcription factor;Transcriptional Regulation;uptake

PROJECT_TITLE: Tissue-specific functions of thyroid hormone receptors


NIH_SPENDING_CATS: Clinical Research;Diabetes;Digestive Diseases;Obesity;Rare Diseases

PI_NAMEs: BROWN, REBECCA  (contact)

PROJECT_TERMS: Acromegaly;Adipose tissue;Autoantibodies;Cardiovascular Diseases;Cells;Clinical Research;Collaborations;Diabetes Mellitus;Disease;Dyslipidemias;Etiology;Familial generalized lipodystrophy;Familial partial lipodystrophy;FDA approved;Functional disorder;Genes;Glucose;HIV-Associated Lipodystrophy Syndrome;Hormones;Insulin;Insulin Receptor;Insulin Resistance;Insulin Signaling Pathway;interest;Intramural Research Program;Learning;Lipodystrophy;Metabolic;Molecular;Molecular Genetics;Mutation;National Institute of Diabetes and Digestive and Kidney Diseases;Natural History;non-alcoholic fatty liver disease;Non-Insulin-Dependent Diabetes Mellitus;Obesity;Pathway interactions;patient population;Patients;Plasma;Rare Diseases;Receptor Gene;Recording of previous events;Reporting;reproductive;Resistance;response;Syndrome;Texas;Therapeutic;Universities

PROJECT_TITLE: Molecular and Clinical Studies of Insulin Resistance


NIH_SPENDING_CATS: Clinical Research;Diabetes;Digestive Diseases;Nutrition;Obesity;Orphan Drug;Rare Diseases

PROJECT_TERMS: Adipocytes;adipokines;Adipose tissue;Agonist;Amino Acids;Animal Model;Antibodies;Biology;Blood Glucose;Body Weight decreased;Clinical;clinical efficacy;Clinical Trials;Disease;Eating;Endocrine;Endocrine Glands;Excretory function;Familial generalized lipodystrophy;Fasting;Fatty acid glycerol esters;FDA approved;Gene Mutation;Genes;Glycosylated hemoglobin A;Goals;Heart Hypertrophy;Hormones;Human;improved;Insulin;Insulin Receptor;Insulin Resistance;Intervention;Leptin;Leptin deficiency;leptin receptor;Leptin resistance;lipid biosynthesis;Lipodystrophy;Liver;Liver Function Tests;Measures;Metabolic;Morbid Obesity;Mus;Mutation;nonalcoholic steatohepatitis;novel;novel therapeutics;Obese Mice;Obesity;Oxidative Stress;Patients;polypeptide;Proteins;Quality of life;Replacement Therapy;reproductive function;Rodent;Safety;Severities;Steatohepatitis;Tissues;Triglycerides;Urine;Weight;Work

PROJECT_TITLE: Clinical utility of leptin therapy in syndromic forms of insulin resistance.


NIH_SPENDING_CATS: Emerging Infectious Diseases;Infectious Diseases

PI_NAMEs: BERNSTEIN, HARRIS  (contact)

PROJECT_TERMS: alpha helix;Antibiotics;Antigens;Bacterial Infections;Bacterial Outer Membrane Proteins;Bacterial Translocation;beta barrel;Biogenesis;Biological;Biology;Bioremediations;Bordetella pertussis;C-terminal;Cell Physiology;Chloroplasts;clinical development;Complex;Escherichia coli;Evolution;Exhibits;experimental study;extracellular;Extracellular Space;Family;Goals;Gram-Negative Bacteria;Homeostasis;Hydrophobic Surfaces;In Vitro;in vivo;inhibitor;insight;Integral Membrane Protein;interest;Libraries;Link;Lipid Bilayers;lipidomics;Lipids;Mediating;member;Membrane;Membrane Proteins;Methods;Mitochondria;Modeling;monomer;mutant;N-terminal;novel;Nutrient;Organism;Paper;Pathogenicity;Peripheral;periplasm;Periplasmic Proteins;pertactin;Play;polypeptide;Property;Protein Family;protein function;Protein translocation;Proteins;proteoliposomes;prototype;Pseudomonas aeruginosa;Reaction;reconstitution;Reporting;Role;scaffold;screening;Structure;Surface;Technology;Testing;Transmembrane Domain;uptake;Vaccine Antigen;Vaccines;Virulence;Virulence Factors;Work

PROJECT_TITLE: Biogenesis of bacterial outer membrane proteins


NIH_SPENDING_CATS: Clinical Research;Dietary Supplements;Kidney Disease;Nutrition;Prevention

PI_NAMEs: LEVINE, MARK A (contact)

PROJECT_TERMS: absorption;Adopted;alpha Tocopherol;antiretroviral therapy;ascorbate;Ascorbic Acid;Ascorbic Acid Deficiency;Austria;Biochemistry;Biological Availability;Blood;Canada;China;Clinical;clinical center;Clinical Data;Clinical Research;cohort;Collection;Coupled;Data;Data Analyses;Denmark;Detection;Diabetes Mellitus;Diet;dietary;Disease;disorder prevention;Dose;Drug Kinetics;experimental study;Fabry Disease;Fatty Liver;Filtration;France;Functional disorder;Germany;Goals;Health;High Pressure Liquid Chromatography;High Prevalence;HIV;HIV therapy;Hospitalization;Hour;Human;In Situ;Ingestion;Intake;Intestinal Absorption;Japan;Kidney;Kidney Diseases;Kinetics;Learning;Malignant Neoplasms;Measurement;Mediating;men;Modeling;Molecular;Molecular Biology;novel;Oral Ingestion;Persons;Physiological Processes;Physiology;Plasma;Prevalence;prevent;Publishing;Rare Diseases;Recommendation;Recommended Dietary Allowance;Renal function;Reporting;Role;Safety;sample collection;Sampling;sex;Single Nucleotide Polymorphism;Specificity;Techniques;Therapeutic;Tissues;Tocopherols;Uncertainty;United States;United States National Academy of Sciences;United States National Institutes of Health;urinary;Urine;Validation;Vitamin Deficiency;Vitamin E;Vitamins;Woman;X-Linked Genetic Diseases;young man;young woman

PROJECT_TITLE: Vitamin C (ascorbic acid) recommended dietary ingestion


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dietary Supplements

PROJECT_TERMS: absorption;Acids;Advanced Malignant Neoplasm;Animal Model;Animals;Anti-viral Agents;Antibiotics;ascorbate;Ascorbic Acid;Bacteria;Biological Availability;Blood;Blood Vessels;Bypass;cancer cell;cancer therapy;Case Series;Cell Death;Cells;Cessation of life;chemical synthesis;chemotherapy;Clinic;Clinical;Clinical Trials;cofactor;Consumption;Coupled;COVID-19;Data;demethylation;design;Diffusion;Disease;DNA;DNA Damage;Dose;double-blind placebo controlled trial;Drug Kinetics;Enzymes;Evaluation;Excretory function;experimental study;extracellular;Extramural Activities;Generations;Glutathione;Homeostasis;Human;Hydrogen Peroxide;Immune checkpoint inhibitor;In Vitro;in vivo;Infectious Agent;Intravenous;intravenous administration;Investigation;Iron;Kidney;Laboratories;Light;Malignant Neoplasms;Measurement;Mediating;Membrane;Metals;Mitochondria;Modality;Molecular Mechanisms of Action;novel;Oral;Oral Ingestion;Outcome;oxidation;Pathologic;Patients;Pattern;Peroxidases;Persons;pharmacokinetic model;pharmacologic;Pharmacologic Ascorbate;Phase;Phase I/II Trial;Phase II Clinical Trials;Physicians;Physiological;Placebo Control;Plasma;Play;Poly(ADP-ribose) Polymerases;pre-clinical;prevent;Prodrugs;Proteins;Publishing;Reactive Oxygen Species;Recommended Dietary Allowance;repaired;Reporting;Research Personnel;Role;Safety;Sepsis;Testing;Therapeutic;Time;Tissues;Toxic effect;treatment group;tumor growth

PROJECT_TITLE: Ascorbic acid as a pharmacologic agent in disease treatment


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Clinical Research;Complementary and Integrative Health;Dietary Supplements;Digestive Diseases;Liver Disease;Nutrition;Obesity;Prevention;Women's Health Research

PROJECT_TERMS: absorption;alpha Tocopherol;bench to bedside;Biological Availability;Biological Markers;Canada;Circulation;Clinical;Clinical Research;Country;Data;Deuterium;Diet;dietary;Dietary intake;dietary requirement;Disease;Dose;Drug Kinetics;Erythrocytes;experimental study;Fat-Soluble Vitamin;Fatty acid glycerol esters;Fatty Liver;Foundations;Functional disorder;Goals;Health;Hemolysis;Hepatitis;Hour;Human;Hydrogen Peroxide;improved;In Vitro;Ingestion;Institutionalization;Intravenous;intravenous administration;Kinetics;Label;Lipoproteins;Liver;Measures;men;Movement;nonalcoholic steatohepatitis;Obesity;Oral;Oral Administration;Pathway interactions;Persons;Physiology;Preparation;prevent;Recommendation;Recommended Dietary Allowance;stable isotope;Steatohepatitis;Testing;validation studies;Vitamin E;Vitamin E Deficiency;Vitamins;Weight;Woman;Work

PROJECT_TITLE: Vitamin E Pharmacokinetics And Biomarkers In Normal And Obese Women


PROJECT_TITLE: Vitamin C (ascorbic acid) physiology


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Hepatitis;Hepatitis - B;Infectious Diseases;Liver Disease;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Nonembryonic - Non-Human

PI_NAMEs: LIANG, T. JAKE  (contact)

PROJECT_TERMS: 3-Dimensional;Affect;Africa;alpha helix;Amino Acid Sequence;Amino Acids;Anti-viral Response;Binding;Binding Proteins;Bioinformatics;Biological Assay;Biological Models;C-terminal;Cell Cycle Progression;Cells;CHD4 gene;Clinical;comparison control;Complex;Cysteine;deep learning;Dependence;Disease;Enzyme-Linked Immunosorbent Assay;Europe;Exclusion;Exhibits;extracellular;Fluorescence;Gene Proteins;Genes;Genetic Polymorphism;Genotype;HBV Genotype;HBXIP gene;Helix-Turn-Helix Motifs;Hepatitis;Hepatitis B;Hepatitis B Infection;Hepatitis B Virus;Hepatitis B X-Protein;Hepatocyte;HepG2;Homologous Gene;Human;Immune;in silico;In Vitro;in vivo;in vivo Model;Individual;Infection;insight;Integration Host Factors;Interferon alpha;Intervention;Investigation;knock-down;Knock-out;KRAS2 gene;Length;Libraries;Life Cycle Stages;lipid biosynthesis;Literature;Liver;Liver diseases;Modeling;Molecular;Mus;Mutagenesis;Mutation;N-terminal;Natural Immunity;Neuroblastoma;novel;NRAS gene;Nuclear Receptors;Nucleic Acids;Nucleotides;Oncogenes;Pathogenesis;Peptides;Persons;Phenotype;predictive modeling;Process;Productivity;protein expression;Protein Isoforms;Proteins;replication factor C;Reporting;screening;Sequence Alignment;Simian virus 5;Small Interfering RNA;Solubility;stable cell line;Stains;Structural Models;Structure;Subgroup;T-Lymphocyte;targeted treatment;Tertiary Protein Structure;therapeutic development;three-dimensional modeling;Transfection;Translating;United States;Validation;Variant;Viral;Viral Antigens;Virus;Virus Diseases;Virus Replication;Virus-Cell Membrane Interaction;Western Blotting;whole genome

PROJECT_TITLE: Molecular Mechanisms Of Hepatitis B Viral infection, Pathogenesis And Persistence


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Cancer;Chronic Liver Disease and Cirrhosis;Coronaviruses;Coronaviruses Therapeutics and Interventions;Digestive Diseases;Emerging Infectious Diseases;Hepatitis;Hepatitis - B;Hepatitis - C;Infectious Diseases;Liver Cancer;Liver Disease;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Nonembryonic - Non-Human

PROJECT_TERMS: 2019-nCoV;Affect;anti-hepatitis B;Anti-viral Agents;anti-viral efficacy;antiviral drug development;Attenuated;Biological Assay;Biological Models;Cell Culture Techniques;Cell fusion;Cell model;Cell Survival;Cells;Chronic;Chronic Hepatitis;Chronic Hepatitis B;Clinical;COVID-19;COVID-19 patient;cytotoxic;cytotoxicity;Detection;Development;Disease;drug development;Goals;Hepatitis B e Antigens;Hepatitis B Virus;Hepatitis C;Hepatitis C virus;Hepatocyte;HepG2;high risk;high throughput screening;Human;Immune;Immunosorbents;in silico;infancy;Infection;interest;Investigation;Libraries;Link;Liver Cirrhosis;liver injury;luminescence;Measures;Mediating;Modeling;Molecular;Mutation;Normal Cell;novel;novel therapeutics;Nuclear Magnetic Resonance;Pathogenicity;Patients;Pharmacologic Substance;Population;preclinical study;Primary carcinoma of the liver cells;Public Health;remdesivir;SARS-CoV-2 B.1.1.529;SARS-CoV-2 infection;Site;small molecule;small molecule libraries;Technology;Therapeutic;Titrations;transmission process;vaccine access;Vaccines;Validation;Variant;Viral;viral DNA;Viral hepatitis;Virus;Virus Diseases;Virus Replication

PROJECT_TITLE: Molecular Approaches To Antiviral Development For Viral Hepatitis and Other Viral Diseases


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Gene Therapy;Genetics;Hepatitis;Hepatitis - C;Immunization;Infectious Diseases;Liver Disease;Nanotechnology;Prevention;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Nonembryonic - Non-Human;Vaccine Related

PROJECT_TERMS: Adaptive Immune System;Affinity;Animal Model;Anti-viral Agents;Anti-viral Response;Antibodies;Binding;Biological Assay;Biological Models;Blood specimen;Cells;Complex;design;Development;Encapsulated;Endosomes;Engraftment;Genotype;Glycoproteins;Hepatitis B Therapy;Hepatitis C;Hepatitis C Therapy;Hepatitis C Vaccine;Hepatitis C Viremia;Hepatitis C virus;Hepatocyte;Human;immunodeficiency;Immunoprecipitation;improved;In Vitro;in vivo;in vivo Model;Infection;Interferometry;Intravenous;Length;Libraries;lipid nanoparticle;Liver;Liver diseases;Mediating;model development;Modeling;Molecular;Monitor;mouse model;Mus;nanobodies;nanoparticle delivery;Negative Staining;neutralizing antibody;non-alcoholic fatty liver disease;Oral Administration;Pan Genus;Phage Display;Preventive vaccine;Process;Production;Proteins;Receptor Cell;Recombinants;Reproducibility;RNA;Serum;Source;Structure;Study models;Technology;therapeutic vaccine;therapy development;Transfection;Transmission Electron Microscopy;treatment response;vaccine candidate;vaccine development;Viral;Viral hepatitis;Viremia;Virus Replication;X-Ray Crystallography

PROJECT_TITLE: Therapy, Vaccine and Model Development in Viral Hepatitis and Liver Diseases


PROJECT_TERMS: absorption;Animals;ascorbate;Ascorbic Acid;Biochemistry;Blood Component Removal;Brain;Cells;Computer software;Data;Data Analyses;Depressed mood;Disease;DNA Methylation;Dose;Drug Kinetics;Epithelium;Excretory function;Filtration;Gene Expression;Genes;Genetic;Genetic Transcription;Growth;Human;human subject;in vivo;Inbred BALB C Mice;Inbreeding;Individual;Intake;Intestinal Absorption;Investigation;Kidney;Knockout Mice;Laboratories;Learning;Lymphocyte;Messenger RNA;Molecular Biology;monocyte;Mus;Neurons;Nutrient;Pathway interactions;Physiological Processes;Plasma;Play;Population;Recommended Dietary Allowance;Regulation;response;RNA;Single Nucleotide Polymorphism;Testing;Time;Tissues;trend;Urine;Weaning;Whole Blood;Woman

PROJECT_TITLE: Vitamin C (ascorbic acid) Biochemistry and Molecular Biology


NIH_SPENDING_CATS: Genetics;Microbiome;Nutrition

PI_NAMEs: REHERMANN, BARBARA  (contact)

PROJECT_TERMS: Adult;Antibiotics;Bacteria;bacteriome;C57BL/6 Mouse;Cell Maturation;Cell Physiology;Chronic;Complex;diet-induced obesity;Disease;Embryo Transfer;experimental study;follow-up;Fostering;fungus;Generations;Genes;Genetic;Goals;gut microbiota;Hepatic;High Fat Diet;High Prevalence;host-microbe interactions;Human;Immune;Immune response;Immunity;Immunologic Factors;Immunologics;Inflammation;Inflammatory;Laboratories;Laboratory mice;Life;Lymphoid;Lymphoid Cell;Mammals;Metabolic;Metabolism;Microbe;microbial;microbiome;microbiome analysis;microbiome therapeutics;microbiota;Mites;Modeling;Modernization;mouse model;Mus;Myelogenous;Nature;offspring;Organ;pathogen;Pathogenesis;Phase;Phenotype;Physiology;Pre-Clinical Model;preclinical study;programs;prospective;Protozoa;Regulation;Regulatory T-Lymphocyte;Reporting;response;Ribosomal RNA;rRNA Genes;Science;Series;Sex Bias;Shapes;stool sample;systemic inflammatory response;Time;Virus;women versus men

PROJECT_TITLE: Regulation of hepatic and systemic immune responses


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Chronic Liver Disease and Cirrhosis;Coronaviruses;Coronaviruses Vaccines;Digestive Diseases;Emerging Infectious Diseases;Genetics;Hepatitis;Hepatitis - B;Hepatitis - C;Immunization;Infectious Diseases;Liver Disease;Microbiome;Nanotechnology;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Vaccine Related;Women's Health Research

PROJECT_TERMS: 16S ribosomal RNA sequencing;Acute;adaptive immune response;Affect;Anti-viral Therapy;Antibodies;Antineoplastic Agents;Area;Award;B-Lymphocyte Subsets;B-Lymphocytes;bench to bedside;Cell Nucleus;Chronic Hepatitis B;chronic infection;Chronic viral hepatitis;circular RNA;Cirrhosis;Clinical;co-infection;Cosmetics;cost;COVID-19 pandemic;Data;differential expression;Disease;DNA Viruses;Drug Kinetics;effective therapy;end stage liver disease;fecal microbiota;First Pregnancy Trimester;Flare;follow-up;Genes;genetic signature;Genetic Transcription;Genome;gut microbiome;gut microbiota;Hepatitis;Hepatitis B Therapy;Hepatitis B Virus;Hepatitis C virus;Hepatitis Delta Virus;Hepatitis Viruses;Hepatocyte;Immune;Immune response;immunogenic;Immunoglobulin G;Immunoglobulin M;Immunology;Infection;Inflammatory Response Pathway;Innate Immune Response;liver inflammation;Malignant neoplasm of liver;medical schools;Messenger RNA;microbial;microbiota;microbiota composition;Modeling;nanoparticle;pandemic disease;Pathogenesis;patient population;Patients;Pattern;Pegylated Interferon Alfa;Peripheral Blood Mononuclear Cell;Persons;Pharmaceutical Preparations;Phase;Play;Polyethylene Glycols;post pregnancy;Postpartum Period;pre-pandemic;Pregnancy;Preventive vaccine;Process;programs;prospective;Prospective Studies;Regulatory Pathway;Reporting;Research;RNA vaccine;RNA Viruses;Role;SARS-CoV-2 antibody;SARS-CoV-2 spike protein;Second Pregnancy Trimester;Severity of illness;Signal Transduction;single-cell RNA sequencing;Soaps;Third Pregnancy Trimester;TNF gene;translational medicine;Translational Research;United States National Institutes of Health;unsupervised clustering;Vaccines;Vertical Disease Transmission;Vertical Transmission;Viral;Viral hepatitis;Visit

PROJECT_TITLE: Immunology of Acute and Chronic Viral Hepatitis


NIH_SPENDING_CATS: Genetics;Nutrition

PI_NAMEs: PHILPOTT, CAROLINE  (contact)

PROJECT_TERMS: absorption;Affect;Affinity Chromatography;Anemia;Antibodies;Binding;Binding Proteins;Biochemical;Biological;Biological Assay;cell fixing;Cell Nucleus;Cells;Circulation;cofactor;Computer software;confocal imaging;Confocal Microscopy;Coupled;Defect;Detection;Diet;Dietary Iron;DNA;Enterocytes;Enzymes;Erythrocytes;Exhibits;Ferritin;Fluorescence;Friedreich Ataxia;Genes;Genetic;Genetic Diseases;Genetic Materials;Genome;Growth;hepcidin;Hereditary hemochromatosis;Homeostasis;Hormones;Human;human disease;In Situ;Incubated;intestinal epithelium;Intestines;Iron;iron absorption;iron metabolism;Iron Overload;Kinetics;Label;Ligation;Liver;Location;Maintenance;Mass Spectrum Analysis;Measurement;Mediating;Membrane;metal transporting protein 1;Metals;Methods;Molecular Chaperones;Mus;Nuclear;Nutrient;Nutritional Requirements;Oligonucleotides;Organism;Oxidation-Reduction;Oxidative Stress;Permeability;Process;Production;protein protein interaction;Proteins;Regulation;Reporting;Role;Signal Transduction;Site;Stains;Toxic effect;Toxin;Up-Regulation;uptake;virtual;Visualization

PROJECT_TITLE: Identification of human genes of iron homeostasis


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Hepatitis;Hepatitis - C;Immunotherapy;Infectious Diseases;Liver Disease

PI_NAMEs: HELLER, THEO  (contact)

PROJECT_TERMS: Aftercare;Biology;Blood;Chronic;Chronic Hepatitis;Chronic Hepatitis C;Clinical;Data;Disease;Disease Progression;Enrollment;follow-up;Follow-Up Studies;Hepatitis C;Hepatitis C virus;Hepatitis D;Infection;inhibitor;Intention;interferon therapy;Interferons;Investigation;Laboratories;Liver diseases;Manuscripts;Morbidity - disease rate;mortality;Patients;Phase;prenylation;Process;Publishing;Relapse;Ritonavir;therapy development;treatment trial;United States National Institutes of Health;Viral hepatitis;Work

PROJECT_TITLE: Investigation of management and disease manifestations of viral hepatitis


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Chronic Liver Disease and Cirrhosis;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Vaccines;Digestive Diseases;Emerging Infectious Diseases;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hepatitis;Hepatitis - B;Immunization;Infectious Diseases;Liver Disease;Racial and Ethnic Minority Health Research;Social Determinants of Health;Vaccine Related

PI_NAMEs: GHANY, MARC  (contact)

PROJECT_TERMS: Address;Affect;African American;Age;Alaska Native;analog;anti-IgG;Antibodies;Asian;Biopsy;Black race;Cessation of life;Chronic Hepatitis B;Chronic viral hepatitis;Cirrhosis;Clinical;cohort;cost;COVID-19 vaccination;COVID-19 vaccine;Data;Development;digital;Disease Progression;effective therapy;Effectiveness;Enrollment;Environmental Risk Factor;falls;FDA approved;functional outcomes;Gender;Gene Expression;Gene set enrichment analysis;Genes;genetic element;Genotype;HBV Genotype;Hepatitis B;Hepatitis B e Antigens;Hepatitis B Infection;Hepatitis B Surface Antigens;Hepatitis B Virus;Hepatocyte;Histologic;Hour;Immune response;immunogenicity;Immunologics;improved outcome;Incidence;Individual;Infection;Institutional Review Boards;interest;Interferons;intrahepatic;Knowledge;Liver;liver biopsy;Liver diseases;meetings;Messenger RNA;Modality;multi-racial;Multivariate Analysis;National Institute of Diabetes and Digestive and Kidney Diseases;Natural History;novel;novel strategies;Nucleocapsid;nucleoside analog;Oral;Outcome;Participant;Pathogenesis;Patient Monitoring;Patients;Persons;Pharmaceutical Preparations;Population;post SARS-CoV-2 infection;Prevalence;Primary carcinoma of the liver cells;primary endpoint;Probability;Protocols documentation;Race;racial disparity;racial population;Regimen;Relapse;Reporting;Research;Resistance;response;Risk;RNA vaccine;SARS-CoV-2 infection;SARS-CoV-2 negative;SARS-CoV-2 spike protein;secondary analysis;side effect;Small Interfering RNA;Socioeconomic Factors;Stains;Surrogate Endpoint;Technology;Therapeutic;therapy outcome;Tissue-Specific Gene Expression;transcriptomics;treatment disparity;tribal health;United States;United States National Institutes of Health;Vaccination;Viral;viral DNA;Virus Diseases

PROJECT_TITLE: Natural History, Therapy and Pathogenesis of Chronic Viral Hepatitis B


NIH_SPENDING_CATS: Diabetes;Digestive Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human;Stem Cell Research - Nonembryonic - Non-Human

PI_NAMEs: RANE, SUSHIL  (contact)

PROJECT_TERMS: Acinar Cell;age related;Area;autoimmune pathogenesis;Beta Cell;Binding;Bone Marrow;CCND2 gene;CDK2 gene;CDK4 gene;CDKN2A gene;Cell Compartmentation;Cell Cycle;cell growth;Cell Line;Cell Lineage;Cell Physiology;Cell Proliferation;cell regeneration;Cells;Cellular biology;Chemicals;Clinical;clinical application;Cyclin D1;cyclin-dependent kinase inhibitor 1B;Deterioration;Development;diabetes management;Diabetes Mellitus;diabetes mellitus therapy;diagnostic development;Disease;Ductal Epithelium;E2F transcription factors;Embryo;embryonic stem cell;Endocrine;Epithelium;established cell line;Exhibits;Functional impairment;Generations;Genetic Transcription;Goals;Growth;Hyperplasia;Impairment;inhibitor;Injury;Insulin;Investigation;islet;islet stem cells;Islets of Langerhans;Knockout Mice;Location;Maintenance;Mesenchymal;Mesenchyme;Metabolic stress;mortality;mouse model;Mus;Natural regeneration;novel;Obesity;Organ;Pancreas;pancreas development;Pancreatic Diseases;Pancreatic duct;Pathogenesis;Pathologic;Pathway interactions;Phosphotransferases;Physiological;Play;Pluripotent Stem Cells;postnatal;precursor cell;Primary Cell Cultures;Process;progenitor;Proliferating;proliferation potential;promoter;Property;recruit;Regenerative capacity;Regenerative response;Regulation;Reporting;Research;response;Retinoblastoma Protein;Role;Source;Splenocyte;stem cells;Therapeutic;Toxin;TP53 gene;transdifferentiation;Translating;treatment strategy

PROJECT_TITLE: Cell Cycle Regulators in Pancreatic Development and Disease


NIH_SPENDING_CATS: Cancer;Complementary and Integrative Health;Diabetes;Nutrition;Obesity;Prevention

PROJECT_TERMS: Address;Animal Model;blood glucose regulation;cancer risk;cdc Genes;Cell Cycle;Cell Cycle Progression;Cell Cycle Proteins;Cell Death;Cells;Development;Diabetes Mellitus;energy balance;Energy Metabolism;epidemiologic data;Exercise;Exposure to;Future Generations;genomic locus;Glucose;glucose tolerance;Goals;Growth;High Fat Diet;Homeostasis;Insulin;Investigation;Malignant Neoplasms;Metabolic;mouse model;Mus;Mutation;Obesity;Obesity associated disease;Organ;Pathogenesis;Pathway interactions;Phenotype;Probiotics;Process;Proteins;Public Health;Role;Technology;Tissues;Transforming Growth Factor beta;Transgenic Mice

PROJECT_TITLE: Cell Cycle Regulators in Diabetes and Obesity


PI_NAMEs: PROIA, RICHARD  (contact)

PROJECT_TERMS: age related neurodegeneration;Ataxia;beta-Galactosidase;Biology;Brain;Catabolism;Clinical;CRISPR/Cas technology;Degradation Pathway;Disease;disease mechanisms study;DNA Sequence Alteration;enzyme deficiency;Exhibits;Frontotemporal Dementia;Ganglioside GM1;Gangliosidosis GM1;Gaucher Disease;Gene Expression;gene-editing approach;Genes;GLB1 gene;Glycolipids;Goals;Human;insight;Knockout Mice;Lead;life span;Link;Lipids;Lysosomal Storage Diseases;Mediating;Metabolism;Modeling;mouse model;Mus;Mutation;Nerve Degeneration;Neuraminidase;Neurodegenerative Disorders;neuroinflammation;novel;Parkinson Disease;Patients;Residual state;response;Role;Severities;species difference;Sphingolipids;Tay-Sachs Disease;Testing;Therapeutic;therapeutic target;tool

PROJECT_TITLE: Mouse Models of Novel Sphingolipid Biology and Disease Mechanisms


NIH_SPENDING_CATS: Aging;Biodefense and Related Countermeasures;Brain Disorders;Coronaviruses;Emerging Infectious Diseases;Infectious Diseases;Intellectual and Developmental Disabilities (IDD);Neurodegenerative;Neurosciences;Rare Diseases

PROJECT_TERMS: 2019-nCoV;Acute;age related neurodegeneration;alpha synuclein;Autophagocytosis;Biology;Body System;Brain;brain cell;cell injury;Cell Membrane Structures;Cell Physiology;Complex;coronavirus disease;COVID-19;Disease;disease model;DNA Sequence;DNA Sequence Alteration;Event;Frontotemporal Dementia;Gaucher Disease;gene therapy;Glycosphingolipids;Goals;Hela Cells;Hypoxia;Impairment;Injury;insight;Link;Lipids;Lysosomal Storage Diseases;Mediator;Membrane Structure and Function;Metabolism;mouse model;Mus;mutation correction;Nerve Degeneration;Nervous System;Neurodegenerative Disorders;Neuroglia;neuroinflammation;Neurologic;Neurologic Symptoms;Neurons;Neuropathogenesis;neuropathology;Open Reading Frames;Parkinson Disease;Pathologic;Pathway interactions;Play;Process;Proteins;Role;SARS-CoV-2 infection;Signal Transduction;Sphingolipids;systemic inflammatory response;Tay-Sachs Disease;therapeutic target;therapy development;Virus;Virus Diseases

PROJECT_TITLE: Sphingolipid Biology of Neurodegeneration


NIH_SPENDING_CATS: Brain Disorders;Fragile X Syndrome;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Neurodegenerative;Neurosciences;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

PI_NAMEs: USDIN, KAREN P. (contact)

PROJECT_TERMS: Affect;Alleles;autism spectrum disorder;Basic Science;Brain;CGG repeat;Chromosome Fragile Sites;Clinic;Diagnosis;Disease;Double Strand Break Repair;epigenetic silencing;Event;FMR1 gene;Folic Acid;Fragile X Syndrome;frataxin;Frequencies;Friedreich Ataxia;FXTAS;gene product;Gene Silencing;Genes;Genetic Diseases;Genetic Transcription;genome integrity;Glutaminase;Goals;Heritability;Heterochromatin;Human Genetics;Human Genome;Intellectual functioning disability;interest;Introns;Life;Mediating;messenger ribonucleoprotein;Microsatellite Repeats;Molecular;Mutation;Nature;Nerve Degeneration;Online Mendelian Inheritance In Man;Open Reading Frames;ovarian dysfunction;Pathologic;Pathology;preservation;primary ovarian insufficiency;Process;Progress Reports;Proteins;response;Risk;Risk Management;screening;Spinocerebellar Ataxias;Synapses;Tandem Repeat Sequences;tool;Transcript;Translational Regulation;Untranslated Regions;Work

PROJECT_TITLE: The consequences of the unusual mutation responsible for the Repeat Expansion Diseases


NIH_SPENDING_CATS: Genetics

PI_NAMEs: COHEN-FIX, ORNA  (contact)

PROJECT_TERMS: Affect;Aging;Architecture;Biological Models;Caenorhabditis elegans;Candidate Disease Gene;Cell Cycle;Cell Nucleolus;Cell Nucleus;cell type;Cell Volumes;Cells;Chemicals;Chromosome Segregation;Defect;Development;Disease;Elements;Eukaryota;Exposure to;Gene Expression Profile;Growth;Intervention;Lamins;Lipids;Malignant Neoplasms;Mitosis;Mitotic;model organism;Morphology;mutant;Mutation;neutrophil;Nuclear;Nuclear Envelope;Partner in relationship;Pathology;Pathway interactions;Pheromone;Phospholipids;Play;Process;programs;Proteins;Regulation;response;Role;Saccharomycetales;Shapes;Signal Transduction;System;Testing;transcription factor;vesicle transport;Yeasts

PROJECT_TITLE: Nuclear architecture in budding yeast


NIH_SPENDING_CATS: Brain Disorders;Fragile X Syndrome;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Rare Diseases;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Embryonic - Non-Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PROJECT_TERMS: 5' Untranslated Regions;Address;Affect;Age;Alleles;Binding;Biological Models;CAG repeat;cell type;Cells;CGG repeat expansion;Child;Complex;CRISPR/Cas technology;Data;Diagnosis;Disease;disease model;effective therapy;embryonic stem cell;FMR1 gene;Fragile X Syndrome;Gene Dosage;Genes;Genetic Diseases;genome integrity;genome wide association study;genomic locus;Glutaminase;Goals;Human Genetics;Human Genome;Huntington Disease;In Vitro;Individual;induced pluripotent stem cell;insight;interest;intergenerational;Knock-out;Lesion;Malignant Neoplasms;Mammals;Microsatellite Instability;Microsatellite Repeats;Mismatch Repair;MLH1 gene;Modeling;mouse model;Mutation;null mutation;Online Mendelian Inheritance In Man;Onset of illness;Patients;PMS1 gene;PMS2 gene;preference;prevent;Process;Progress Reports;Proteins;Reporting;Risk;Role;role model;Severity of illness;Shapes;Short Tandem Repeat;Single Nucleotide Polymorphism;Somatic Cell;Testing;Therapeutic;therapeutic target;transmission process;Weight;Work

PROJECT_TITLE: The mutational mechanism responsible for the Repeat Expansion Diseases


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases;Orphan Drug;Rare Diseases

PI_NAMEs: HINTON, DEBORAH M (contact)

PROJECT_TERMS: Amino Acid Transporter;Antibiotic Resistance;Antibiotics;Apical;Bacteria;Bacterial Adhesins;Bacterial Infections;Base Pairing;Betaproteobacteria;Binding Sites;Bioinformatics;Bordetella pertussis;Communicable Diseases;Computer Analysis;Cytoplasm;Data;Data Set;Development;Disease;Disease Outbreaks;DNA-Directed RNA Polymerase;Enzymes;Epithelial Cells;Fatty Acids;gene conservation;Gene Expression;Gene Expression Regulation;gene induction/repression;gene product;Genes;Genetic Transcription;genome-wide;Glycolates;glyoxylate;Goals;Gram-Negative Bacteria;Health;Hemagglutinin;Homologous Gene;Incidence;Infant Mortality;Infection;LacZ Genes;lipid metabolism;Messenger RNA;Metabolic;Metabolic Pathway;Molecular Chaperones;mRNA Stability;mutant;Nucleotides;Organism;pathogen;Pathogenesis;Pathway interactions;Pertussis;Pertussis Vaccine;phenylacetic acid;Phosphorylation;Phosphotransferases;Play;Post-Transcriptional Regulation;Process;programs;promoter;pyruvate dehydrogenase;Regulation;Regulon;Reporter;Repression;response;Reverse Transcription;ribonuclease E;Ribosomes;RNA;Role;sensor;Sigma Factor;Site;Small RNA;Sugar Acids;Symptoms;System;Testing;Time;Toxin;Transcriptional Regulation;transcriptome sequencing;transcriptomics;Translations;transmission process;Type III Secretion System Pathway;Untranslated RNA;Upper respiratory tract;Virulence;Virulence Factors;virulence gene;Western Europe;Work

PROJECT_TITLE: Regulation of Virulence Genes in Bordetella pertussis


NIH_SPENDING_CATS: Antimicrobial Resistance;Autoimmune Disease;Crohn's Disease;Digestive Diseases;Emerging Infectious Diseases;Genetics;Infectious Diseases;Inflammatory Bowel Disease;Pediatric

PROJECT_TERMS: Accounting;Adherent Invasive Escherichia coli;Affect;Ampicillin Resistance;Anabolism;Antibiotic Resistance;antimicrobial;Aspartic Acid;Autoimmune Diseases;Bacteria;Bacterial RNA;beta-Lactamase;Binding;Biological Assay;Biology;Cell Physiology;Cells;Child;cold temperature;Communicable Diseases;Congenital Abnormality;Crohn's disease;Data Set;Development;Diabetes Mellitus;Disease;DNA;DNA-Directed RNA Polymerase;Drug Efflux;efflux pump;Elements;Environment;Escherichia coli;Etiology;Family;fighting;Fucose;Gastrointestinal tract structure;Gene Expression;Gene Expression Process;Gene Expression Regulation;Genes;Genetic;Genetic Transcription;Growth;Housekeeping Gene;Human Development;human disease;Immune;In Vitro;Inflammatory Bowel Diseases;insight;Invaded;Life Style;Liquid substance;Macrophage;Malignant Neoplasms;Membrane;Methionine;Microbial Biofilms;Molecular;mucoid;mutant;Mutation;Nervous System Disorder;Operon;pathobiont;Pathogenesis;pathogenic Escherichia coli;Pattern;Phenotype;Positioning Attribute;Process;promoter;Promoter Regions;Pump;Regulation;Salmonella;Sequence Homologs;Sigma Factor;Single Nucleotide Polymorphism;Spacer DNA;Specificity;Structure;System;Testing;Transcription Initiation;Transcription Initiation Site;Transcriptional Regulation;transcriptome sequencing;Valine;Variant;Work

PROJECT_TITLE: Control of Transcription Initiation


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Diabetes;Frontotemporal Dementia (FTD);Genetics;Neurodegenerative;Neurosciences;Nutrition;Obesity;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human;Stem Cell Research - Nonembryonic - Non-Human

PI_NAMEs: HANOVER, JOHN A. (contact)

PROJECT_TERMS: aging related disease;Alleles;Alzheimer's Disease;Amyloid beta-Protein Precursor;Animal Disease Models;Animal Model;Animals;Beta Cell;Biological Models;Biological Process;Brain;Caenorhabditis elegans;Cell Death;Cells;chromatin immunoprecipitation;Complex;COVID-19 impact;cytokine release syndrome;Data;Defect;detection of nutrient;Development;Diabetes Mellitus;diabetes pathogenesis;differentiation in vitro;Disease;DNA Methylation;DNA Repair;Embryo;embryo cell;embryonic stem cell;Enterobacteria phage P1 Cre recombinase;Enzymes;epigenetic regulation;Excision;Exhibits;Fatty acid glycerol esters;Fibroblasts;fly;FTD with parkinsonism;gain of function;Gene Expression;Genes;Genetic;Genetic Models;Genetic Transcription;Genome;germline stem cells;Glycogen;Goals;Growth;Hexosamines;Human;human disease;hyperphosphorylated tau;Immune;imprint;Inflammatory;Insulin;Insulin Resistance;insulin secretion;insulin signaling;insulin-like signaling;Knock-out;knockout animal;Larva;Leptin;Link;Longevity;loss of function;Macronutrients Nutrition;Malignant Neoplasms;Mediating;Messenger RNA;Metabolic;Metabolic syndrome;Metabolism;Mexican Americans;Mitochondria;Modeling;Molecular;Mus;Muscle;mutant;Nematoda;Nerve Degeneration;Neurodegenerative Disorders;neurogenesis;Neuropathy;Non-Insulin-Dependent Diabetes Mellitus;Nutrient;O-GlcNAc transferase;Obesity;Organism;overexpression;oxidative damage;Pathogenesis;Pathway interactions;peptide O-linked N-acetylglucosamine-beta-N-acetylglucosaminidase;Phosphorylation;Physiological;pituitary gland development;Play;Polycomb;Polysaccharides;promoter;protective effect;Protein Isoforms;Proteins;Receptor Gene;response;reverse genetics;Role;Signal Pathway;Signal Transduction;Signal Transduction Pathway;stem cell biology;stem cell fate;stem cell population;Structure of beta Cell of islet;Susceptibility Gene;tau Proteins;Tauopathies;Technology;Temperature;therapeutic target;Tissues;Transcriptional Regulation;Transgenic Mice;Transgenic Model;Transgenic Organisms;Translations;Trehalose;Triglycerides;Virus Diseases;Work

PROJECT_TITLE: Targeted disruption the enzymes of O-GlcNAc cycling: Animal models of Disease


NIH_SPENDING_CATS: Diabetes;Genetics

PROJECT_TERMS: Ablation;Architecture;autosome;Basic Science;beta catenin;Binding;Biochemical;Caenorhabditis elegans;Calcium;Calmodulin;campomelic dysplasia;cell growth regulation;Cell Nucleus;Cells;Cellular Stress;Clinical Sciences;Defect;Diabetes Mellitus;Disease;DNA;DNA Binding;Family;Genes;Genetic;genetic approach;glycosylation;Goals;gonad development;HMG-Box Domains;Homologous Gene;Human;human disease;Image;inhibitor;Insulin;insulin signaling;Link;Maintenance;male;Mammals;Mediating;member;Molecular;Mus;Mutation;Nematoda;novel;novel strategies;Nuclear;Nuclear Export;Nuclear Import;Nuclear Proteins;nucleocytoplasmic transport;Organism;Pathway interactions;Patients;Phenotype;Phosphotransferases;Physiological;Population;Process;Proteins;receptor;Regulation;Role;Running;sensor;sertoli cell;sex;Signal Transduction;small molecule;small molecule inhibitor;Stem cell pluripotency;Susceptibility Gene;Syndrome;System;TCF7L2 gene;trafficking;transcription factor;Translating;uptake;Work;Yeasts

PROJECT_TITLE: Calmodulin-driven Nuclear Trafficking linked to diabetes and insulin signaling


PROJECT_TERMS: Acetylation;Adhesiveness;alpha Karyopherins;Animal Model;Apoptosis;Apoptotic;Biochemistry;Biology;casein kinase;Catalytic Domain;cell growth;Cell Nucleus;Cell Proliferation;Cells;Chemicals;Chromatin;Chronic Disease;Complex;Coronary Arteriosclerosis;COVID-19;Cryoelectron Microscopy;cytokine release syndrome;Cytoplasm;Defect;detection method;detection of nutrient;Development;Diabetes Mellitus;Diagnostic;Disease susceptibility;Dissection;DNA Methylation;DNA Methylation Regulation;DNA Repair;Environment;enzyme substrate;Enzymes;Epigenetic Process;Escherichia coli;Excision;Exhibits;Fibroblasts;Future;Gene Chips;Gene Expression;gene product;gene repression;Genes;Genetic;Genetic Transcription;Glycogen;Glycogen Synthase Kinase 3;Hexosamines;high throughput screening;High-Throughput Nucleotide Sequencing;histone acetyltransferase;Histone Deacetylase;Histones;Human;Image;Immune system;imprint;inhibitor;Insulin Resistance;insulin signaling;intrauterine environment;Length;Leptin;Link;Lipids;Mediating;Metabolic Diseases;Metabolism;Methods;Methylation;Mitochondria;Modification;Molecular;Morbidity - disease rate;Movement;multicatalytic endopeptidase complex;Mutation Analysis;Natural Products;Nerve Degeneration;Neurodegenerative Disorders;Non-Insulin-Dependent Diabetes Mellitus;Nuclear;Nuclear Pore Complex;nucleocytoplasmic transport;Nutrient;Nutrient availability;Obesity;Oxidative Stress;Participant;Pathway interactions;peptide O-linked N-acetylglucosamine-beta-N-acetylglucosaminidase;Phosphorylation;Phosphotransferases;Play;Polysaccharides;Predisposition;Proliferating;protein complex;Protein Isoforms;Proteins;Reagent;recruit;Regulation;Resistance;response;Role;sensor;Signal Pathway;Signal Transduction;Signal Transduction Pathway;Signaling Molecule;Site;Site-Directed Mutagenesis;Skeletal Muscle;small molecule inhibitor;stem cell self renewal;Stimulus;Structure;sugar nucleotide;Techniques;Technology;Testing;Therapeutic;Virus Diseases;X Chromosome

PROJECT_TITLE: Enzymes of O-GlcNAc cycling linked to type-2 diabetes and neurodegeneration


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Breastfeeding, Lactation and Breast Milk;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Genetics;Human Genome;Infectious Diseases;Kidney Disease

PI_NAMEs: HENNIGHAUSEN, LOTHAR  (contact)

PROJECT_TERMS: 2019-nCoV;Acceleration;Affect;Alternative Splicing;Atlases;Binding;Binding Sites;biochemical tools;Biological;Biological Process;Biological Response Modifiers;Biomedical Research;Cells;Cessation of life;clinically relevant;cohort;combinatorial;Combined Modality Therapy;Complex;Computational Science;Computer Hardware;Computing Methodologies;COVID-19 pandemic;COVID-19 patient;CRISPR/Cas technology;cytokine;Data Set;Detection;Development;Disease;Distal;Elements;Enhancers;Epigenetic Process;Exhibits;Experimental Genetics;Explosion;Focal and Segmental Glomerulosclerosis;Fostering;gene discovery;Gene Expression;Gene Expression Profile;Gene Expression Regulation;gene regulatory network;Genes;Genetic;genetic approach;genetic architecture;Genetic Epistasis;Genetic Transcription;Genome;genome editing;Genome engineering;Genomics;glomerulosclerosis;Growth;Heritability;Histologic;Hormonal;Hormones;Human;human disease;Human Genome;Immune;Immune response;immune RNA;Immune system;immunoregulation;improved;in vivo;Individual;Injury;insight;interdisciplinary approach;Interleukin-15;Interleukins;International;international partnership;Investigation;Janus kinase;Kidney;kidney cell;Kidney Diseases;kidney dysfunction;Lactation;leukemia;Link;Mammals;mammary;Mammary gland;mammary gland development;Medicine;Messenger RNA;milk production;Molecular;mouse genome;mouse model;Mutation;Network-based;novel therapeutics;organ growth;Pathway interactions;Patients;Pattern;Phosphorylation;Physiology;podocyte;Pregnancy;Premature aging syndrome;Prognosis;programs;Prolactin;Publications;Publishing;quantum computer;quantum computing;Regulatory Element;Renal glomerular disease;Reporting;Reproducibility of Results;Research;Risk;RNA Splicing;Role;Sampling;SARS coronavirus;SARS-CoV-2 B.1.1.529;SARS-CoV-2 variant;Scientist;sexual dimorphism;Signal Pathway;Signal Transduction;Single Nucleotide Polymorphism;STAT protein;Stat5 protein;Techniques;therapeutic development;therapeutic target;therapeutically effective;Time;Tissues;tool;Transcript;transcription factor;Transcriptional Regulation;transcriptome;transcriptome sequencing;Vaccination;Vaccinee;Variant;Viral;Virus Diseases;Virus Replication

PROJECT_TITLE: Genetic Approaches To Understanding Organ Development and Function


PROJECT_TERMS: Address;Affect;Architecture;Caenorhabditis elegans;Cell Cycle;Cell Nucleus;Cells;Centrosome;Chromosomes;Confocal Microscopy;CRISPR/Cas technology;Development;Disease;Electron Microscopy;Elements;Embryo;Fertilization;Genes;Genetic;genetic regulatory protein;Genome;Goals;insight;Lead;Libraries;Link;Malignant Neoplasms;Mammals;Membrane;Microtubules;migration;Mitosis;Morphology;Mus;novel;Nuclear;Nuclear Envelope;Nuclear Structure;Organelles;Permeability;PLK1 gene;Premature aging syndrome;Process;Proteins;Resolution;Reticulum;RNA Interference;Role;Shapes;Structural Protein;Testing;Tubulin;Yeasts

PROJECT_TITLE: Nuclear architecture in C. elegans


NIH_SPENDING_CATS: Behavioral and Social Science;Cannabinoid Research;Childhood Obesity;Clinical Research;Diabetes;Endocannabinoid System Research;Genetics;Nutrition;Obesity;Pediatric;Physical Activity;Prevention

PI_NAMEs: KRAKOFF, JONATHAN  (contact)

PROJECT_TERMS: 10 year old;Acceleration;Adipocytes;Adult;Affect;Age;anandamide;Area Under Curve;Arousal;awake;Basal metabolic rate;Behavior;Biopsy;Body mass index;Body Size;Body Weight;Body Weight Changes;Brain-Derived Neurotrophic Factor;Cell membrane;Ceramides;Childhood;Childhood diabetes;Closure by clamp;cohort;cost;Cross-Sectional Studies;Data;Development;Diabetes Mellitus;diabetes risk;Diabetic Nephropathy;Diabetic Retinopathy;dietary;dihydroceramide desaturase;Dose;Eating;Endocannabinoids;energy balance;Energy Metabolism;Etiology;euglycemia;factor A;Fasting;fasting plasma glucose;Fatty acid glycerol esters;follow-up;Food;gallstone disease;Gene Cluster;Genetic;genetic variant;Glucose;glucose production;glucose uptake;Goals;Hepatic;Hour;Human;Hyperglycemia;Hyperinsulinism;Hyperphagia;Impairment;In Vitro;Individual;Insulin;Insulin Resistance;insulin secretion;interest;Investigation;Kidney Diseases;Life;Lipids;Lipolysis;Lipoproteins;Longitudinal Studies;Longterm Follow-up;Low-Density Lipoproteins;Macronutrients Nutrition;Measurement;Measures;Mediating;Mediation;Mediator;Melanocortin 4 Receptor;Metabolic;Metabolic Diseases;metabolic rate;Metabolism;Movement;Muscle;Mutation;Native Americans;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;OGTT;oxidation;Physical activity;Play;Promoter Regions;Receptor Gene;Renal function;Reproducibility;respiratory;response;Rest;Risk Factors;risk prediction;Role;Seasons;sedentary lifestyle;Serum;Signal Transduction;Single Nucleotide Polymorphism;Skeletal Muscle;Sleep;Sphingolipids;Sphingomyelins;Structure of beta Cell of islet;Testing;Thermogenesis;Time;total energy expenditure;Variant;Weight;Weight Gain

PROJECT_TITLE: Risk Factors and Etiology of Obesity and Type 2 Diabetes


NIH_SPENDING_CATS: American Indian or Alaska Native;Clinical Research;Diabetes;Genetics;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Nutrition;Obesity;Pediatric;Prevention;Racial and Ethnic Minority Health Research

PI_NAMEs: HANSON, ROBERT  (contact)

PROJECT_TERMS: Adolescent;Age;American Indian Population;American Indians;Amerindian;Arizona;Basal metabolic rate;Beta Cell;Blood specimen;Body measure procedure;Body Size;Candidate Disease Gene;causal variant;Cell Line;Cell Physiology;Chronic Disease;Collaborations;Data;Diabetes Mellitus;diabetes risk;Disease;DNA;DNA Methylation;epidemiology study;Epigenetic Process;Ethnic Population;exome sequencing;Family;Future;Gene Frequency;Genes;genetic association;Genetic Determinism;genetic epidemiology;genetic information;genetic linkage;genetic pedigree;Genetic Techniques;genome sequencing;genome wide association study;genome-wide;Genotype;Growth;high body mass index;High Prevalence;Incidence;Indigenous American;Individual;Inherited;LDL Cholesterol Lipoproteins;lymphoblast;Maps;maturity onset diabetes of the young;Methods;middle age;Mothers;Native-Born;Nature;Non-Insulin-Dependent Diabetes Mellitus;novel;Nuclear;Obesity;Odds Ratio;Parents;Participant;Persistent Hyperinsulinemia Hypoglycemia of Infancy;Pima Indian;polygenic risk score;Population;population based;Predisposition;recruit;Reproducibility;Retinal Diseases;Risk;risk variant;Role;Sampling;Signal Transduction;Susceptibility Gene;TCF7L2 gene;Variant;whole genome

PROJECT_TITLE: Genetic Epidemiology of Diabetes and Obesity


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Nutrition;Obesity;Prevention

PROJECT_TERMS: Abdomen;Anhedonia;Behavioral;Body Temperature;Body Weight Changes;Brown Fat;Calibration;Calories;Carbohydrates;Characteristics;Cognitive;Consumption;Data;depressive symptoms;deprivation;design;Diet;dietary;Dietary Factors;Dietary Intervention;Dopamine;Drops;energy balance;Energy Metabolism;Enrollment;Epinephrine;examination questions;Excretory function;Expenditure;Fasting;Fatty acid glycerol esters;Fatty Acids;feeding;Fibroblast Growth Factor;fibroblast growth factor 21;flexibility;fluorodeoxyglucose;Future;ghrelin;glucose tolerance;Goals;Heat Losses;High Fat Diet;Hormonal;Hour;Human;Hunger;Individual;Iowa;Lipids;Liver;Longterm Follow-up;Macronutrients Nutrition;Measurement;Measures;Mediating;Metabolic;metabolomics;Modeling;Obesity;Outcome;oxidation;Pancreatic Polypeptide;Participant;PET/CT scan;Phenotype;Physiological;Plasma;precision nutrition;preference;Protein-Restricted Diet;Proteins;rate of change;Reproducibility;Research Design;respiratory;response;Rest;Rodent Model;Role;Scanning;Series;Sleep;Sympathetic Nervous System;Testing;Thermogenesis;Thyroid Gland;Thyroid Hormones;urinary;Visualization;Weight;Weight Gain;weight loss intervention;weight maintenance;Work

PROJECT_TITLE: Factors which predict variance in weight change


NIH_SPENDING_CATS: American Indian or Alaska Native;Diabetes;Genetics;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Pediatric;Racial and Ethnic Minority Health Research;Rare Diseases

PI_NAMEs: BAIER, LESLIE J (contact)

PROJECT_TERMS: Acinar Cell;Adipocytes;Adult;Affect;Affinity;Age;Age of Onset;Alleles;American Indians;Amerindian;Arizona;Bardet-Biedl Syndrome;Binding;Binding Sites;Biological Assay;Birth;Birth Weight;Body fat;Body mass index;Candidate Disease Gene;Cells;Childhood;Clinical;clinical care;Code;Collaborations;Communities;Complement 3a;Complex;Data;Development;Diabetes Mellitus;Diagnosis;Disease;early onset;Enzymes;Exocrine pancreas;exome;fetal;Frequencies;Functional disorder;G-Protein-Coupled Receptors;Gene Frequency;Genes;Genetic;Genetic Transcription;Genetic Variation;Genotype;glucagon-like peptide 1;glucose metabolism;glucose production;Growth;Health;High Prevalence;Homology Modeling;Human;Hyperinsulinism;IGF1R gene;Impairment;In Vitro;Indigenous;indigenous community;Individual;innovation;Insulin;Insulin Resistance;insulin secretion;Insulin-Like Growth Factor Binding Protein 4;knock-down;Knockout Mice;Leptin;lipid biosynthesis;lipid metabolism;Lipolysis;loss of function;Low Birth Weight Infant;Luciferases;Maintenance;Measurement;Measures;Mediating;Medical Records;member;molecular dynamics;Morbid Obesity;Mus;Mutation;Native-Born;neonatal diabetes mellitus;Neuropeptides;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;overexpression;pancreas development;Pathway interactions;Peptides;Peroxisome Proliferator-Activated Receptors;Persistent Hyperinsulinemia Hypoglycemia of Infancy;Persons;Pharmacotherapy;Phosphorylation;Physiological;PI3K/AKT;Pima Indian;Population;population based;postnatal;Predisposition;prenatal;Privatization;promoter;protective allele;Proteins;prototype;public database;rare variant;receptor;receptor binding;Reporting;Risk;risk variant;RNA;Rodent;Role;Sampling;Signal Transduction;STAT3 gene;Structure-Activity Relationship;Transactivation;Tribes;United States;Untranslated RNA;Variant;Western Blotting;Woman

PROJECT_TITLE: Structural Analysis Of Candidate Genes For Type 2 Diabetes and Obesity


NIH_SPENDING_CATS: American Indian or Alaska Native;Biotechnology;Clinical Research;Diabetes;Genetics;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Nutrition;Obesity;Racial and Ethnic Minority Health Research

PI_NAMEs: BOGARDUS, CLIFTON  (contact)

PROJECT_TERMS: Adipose tissue;Age;Arizona;Body Composition;Body mass index;Complement;Data;Diabetes Mellitus;Disease;exome;exome sequencing;Exons;Expression Profiling;follow-up;Functional disorder;Gene Expression;Gene Expression Profiling;Genes;Genetic;Genetic Polymorphism;genome sequencing;genome wide association study;Genotype;Glucose Clamp;glucose production;High Prevalence;Hyperinsulinism;in vivo;Incidence;Insulin;Insulin Resistance;metabolic phenotype;Muscle;Native American population;non-diabetic;Non-Insulin-Dependent Diabetes Mellitus;Nucleotides;Obesity;Pima Indian;Population;Predisposition;Prevalence;prototype;Reporting;Single Nucleotide Polymorphism;Skeletal Muscle;Susceptibility Gene;Tissue Sample;Transcript;volunteer;whole genome;Work

PROJECT_TITLE: Gene Expression Profiling On Insulin Resistance And Obesity


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Neurosciences;Nutrition;Obesity;Prevention

PROJECT_TERMS: active method;Affect;Anodes;Area;Body Composition;Body Weight Changes;Body Weight decreased;Brain;brain magnetic resonance imaging;Brain region;Central Nervous System;Cognitive;cognitive testing;Data;Decision Making;density;Desire for food;Development;Eating;Energy Intake;Energy Metabolism;Failure;follow-up;Food;food craving;Functional Magnetic Resonance Imaging;Goals;gray matter;Hormones;Hunger;improved;Individual;Inflammatory;Intake;Interleukin-6;Intervention;Left;Magnetic Resonance Imaging;Measures;Mediating;men;metabolic rate;Neuroanatomy;neuroimaging;Neurons;obese person;Obesity;Outpatients;Patients;Performance;Positron;Positron-Emission Tomography;Prefrontal Cortex;prefrontal lobe;Procedures;Research Design;reward processing;Role;Satiation;satiety center;Scanning;Testing;Thinness;transcranial direct current stimulation;treatment effect;treatment group;Woman

PROJECT_TITLE: Neuronal activity and its role in adiposity and food intake