ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

ORG_CITY: ATHENS

ORG_NAME: UNIVERSITY OF GEORGIA

PHR: PROJECT NARRATIVE The ideal antibacterial and hemocompatible surface would prevent bacterial biofilm formation as well as platelet adhesion and activation. This research project will develop and evaluate the synergistic effects of S-nitrosothiol based nitric oxide (NO) release along with a surface immobilized catalytic heparin moiety that can extend the therapeutic levels of nitric oxide for longer periods. These materials will be studied for their prevention of platelet activation/adhesion, fibrin formation, and microbial infection, thereby solving major clinical problems of thrombosis and infection associated with long-term intravascular catheter devices.

PI_NAMEs: HANDA, HITESH  (contact)

PROGRAM_OFFICER_NAME: WARREN, RONALD Q

PROJECT_TERMS: Adhesions;Adsorption;analytical method;Anti-Bacterial Agents;Antibiotics;Anticoagulation;antimicrobial;Artificial Organs;Bacteremia;Bacteria;Bacterial Adhesion;Bacterial Infections;Binding;Bioreactors;Blood;Blood Platelets;Blood Vessels;Blood-Borne Pathogens;catalyst;Catheter-related bloodstream infection;Catheters;Cell Line;Cells;Cessation of life;Clinical;clinical application;clinical development;clinical translation;Coagulation Process;Complex;Conscious;data integration;Devices;early phase clinical trial;Embolism;Engineering;Exposure to;fabrication;Fibrin;Formulation;Generations;Goals;Health Care Costs;Healthcare Industry;hemocompatibility;Heparin;Hour;Immobilization;implantable device;improved;In Vitro;in vitro Bioassay;Indwelling Catheter;Infection;Infection prevention;inhibitor;Intensive Care Units;Klebsiella pneumoniae;Lead;Legal patent;Life;Local Anti-Infective Agents;Measures;Medical;microbial;Microbial Biofilms;Modeling;N-acetylpenicillamine;Nitric Oxide;Nitric Oxide Donors;Obstruction;Oryctolagus cuniculus;Patient Care;Patients;Peripheral;Platelet Activation;Polymers;Polyurethanes;prevent;Prevention;Property;Proteins;Pseudomonas aeruginosa;Research Project Grants;Risk;S-Nitrosothiols;Safety;Silicones;Staphylococcus aureus;Staphylococcus epidermidis;Sterilization;success;Surface;synergism;Technology;Testing;Therapeutic;Thrombin;Thrombosis;Thrombus;Translations;United States;Vascular Endothelial Cell;Venous;Work

PROJECT_TITLE: Engineering nitric oxide releasing polymer with immobilized thrombin inhibitor for blood contacting applications

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]


ADMINISTERING_IC: CA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF NURSING

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: MINNEAPOLIS

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: The foods and beverages people shop for and store in their homes are related to the foods they consume and the development of diet-related diseases such as obesity, cancer, cardiovascular disease and diabetes. Research to address health disparities in diet-related disease is critical but often stymied by the lack of measurement tools that are specific, appropriate, and valid for diverse populations such as Latinos. The proposed research will develop and make available a toolkit of valid home food inventories to use in diet- related health research to reduce health disparities among Latino and low-literacy populations.

PI_NAMEs: FULKERSON, JAYNE ALLYN (contact)

PROGRAM_OFFICER_NAME: HERRICK, KIRSTEN ANNE

PROJECT_TERMS: Address;Adoption;Adult;Assessment tool;Benchmarking;Beverages;burden of chronic illness;Cardiovascular Diseases;cardiovascular disorder risk;Cause of Death;Chronic;Chronic Disease;Consumption;Development;Diabetes Mellitus;Diet;Disease;disorder risk;Electronics;Enrollment;Equipment and supply inventories;ethnic minority population;Expenditure;Fatty acid glycerol esters;Food;food consumption;food environment;Funding;Future;Health;Health Disparities Research;health disparity;Health Food;Heart Diseases;High Prevalence;Hispanic Community Health Study/Study of Latinos;Home;hypercholesterolemia;Immigrant;Infrastructure;innovation;instrument;Intervention;Language;Latino;Latino Population;literacy;Low income;Low Literacy Population;Malignant Neoplasms;Measurement;Measures;men;Multimedia;Nutrient;Obesity;obesity risk;obesogenic;Paper;Participant;Persons;Population;population health;Population Heterogeneity;prevent;Process;Reduce health disparities;repository;Research;Risk Factors;Science;Spanish;Spanish/English;statistics;sugar;Technology;Testing;tool;Training;Unhealthy Diet;United States;United States National Institutes of Health;usability;validation studies;Validity and Reliability;Visual;Weight Gain;western diet;Woman;Work;Writing

PROJECT_TITLE: Innovation in Measurement for Diet-Related Disease Research: Optimizing Utility and Reach to Reduce Health Disparities

STUDY_SECTION: PRDP

STUDY_SECTION_NAME: Psychosocial Risk and Disease Prevention Study Section[PRDP]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Cancer;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: LA JOLLA

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

ORG_STATE: CA

PHR: Narrative Fundamental new approaches and new therapeutics for the treatment of resistant bacterial infections (MRSA, VRSA, and VRE) will emerge from the studies, including the rational design of remarkably potent, broad spectrum, and especially durable antibiotics that possess multiple independent synergistic mechanisms of action acting on a common pathway. A fundamental understanding of the mechanism of action and the interaction of glycopeptide antibiotic natural products and their analogs with their biological targets will be defined.

PI_NAMEs: BOGER, DALE L (contact)

PROGRAM_OFFICER_NAME: FU, YALI

PROJECT_TERMS: Address;Amides;Anabolism;analog;Antibiotics;antimicrobial;Area;Bacterial Antibiotic Resistance;Bacterial Infections;bacterial resistance;Binding;Biological;Cell surface;Cell Wall;chloropeptin I;Clinic;Clinical;clinically significant;Cyclic Peptides;design;Development;DNA Sequence Alteration;Drug usage;efflux pump;enzyme substrate;Fermentation;Foundations;Glycopeptide Antibiotics;Gram-Negative Bacteria;Gram-Positive Bacteria;Grant;Guanidines;Improve Access;improved;in vivo;innovation;Ligands;Measures;Metabolic;methicillin resistant Staphylococcus aureus;Modeling;Modification;Molecular;Multi-Drug Resistance;Natural Products;next generation;novel strategies;novel therapeutics;Organism;pathogen;pathogenic bacteria;Pathway interactions;Peripheral;preclinical evaluation;Preparation;Public Health;ramoplanin;rational design;Reaction;Reporting;Resistance;Resistance development;resistance mechanism;Series;Structure;therapy resistant;Time;Vancomycin;Vancomycin Resistance;Vancomycin resistant enterococcus;Vancomycin-resistant S. aureus;Work

PROJECT_TITLE: Biologically Active Cyclic Peptides

STUDY_SECTION: SBCB

STUDY_SECTION_NAME: Synthetic and Biological Chemistry B Study Section[SBCB]


NIH_SPENDING_CATS: Biotechnology;Cancer;Digestive Diseases;Esophageal Cancer;Genetics;Lung;Lung Cancer;Orphan Drug;Rare Diseases

ORG_CITY: GRAND RAPIDS

ORG_NAME: VAN ANDEL RESEARCH INSTITUTE

ORG_STATE: MI

PHR: PROJECT NARRATIVE Lung cancer is the leading cause of all cancer-related deaths in the U.S and worldwide. High YEATS2 expression is associated with worse prognosis of several types of cancers including non-small cell lung cancer, indicating that YEATS2 is a potential drug target. The objective of this proposal is to develop potent and specific inhibitors to target the histone acylation binding activity of the YEATS2 YEATS domain that will provide the basis for further development of small molecules for targeted therapies.

PI_NAMEs: SHI, XIAOBING  (contact)

PROGRAM_OFFICER_NAME: FORRY, SUZANNE L

PROJECT_TERMS: 3q26;Acylation;Apoptosis;Binding;Biological Assay;Calorimetry;Cancer Etiology;Cancer Patient;cancer type;cell growth;Cell Survival;Cells;Cessation of life;Characteristics;Chemicals;ChIP-seq;Chromatin;Communities;Complex;Data;Development;DNA Sequence Alteration;DNA-Protein Interaction;Drug Targeting;effective therapy;Ensure;Evolution;flexibility;Fluorescence Polarization;Gene Expression;Genes;Head and neck structure;high throughput screening;Histone Acetylation;histone acetyltransferase;Histone H3;Histones;Human;Impairment;In Vitro;inhibitor;Interferometry;Lead;lung cancer cell;Malignant neoplasm of esophagus;Malignant neoplasm of lung;Malignant Neoplasms;Measurement;Measures;men;meter;mRNA Expression;Non-Small-Cell Lung Carcinoma;novel;Ovarian;Peptides;Permeability;Pharmaceutical Preparations;Prognosis;Proliferating;Proteins;Reader;Reading;Research;response;Role;scaffold;Series;small molecule;small molecule inhibitor;small molecule libraries;Squamous Cell Lung Carcinoma;targeted treatment;Technology;Testing;Therapeutic;Titrations;tool;transcriptome sequencing;Tumor Promotion;Validation;Woman

PROJECT_TITLE: High Throughput Screen for Inhibitors of the YEATS2 Histone Acylation Reader

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-F(55)R]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: KANSAS CITY

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: Parvovirus is pathogenic to humans and has been used as a delivery vector in human gene therapy. The proposed study will identify both the viral and cellular factors that control parvovirus gene expression and DNA replication and will reveal a broad understanding of the mechanisms underlying the error-free Y-family DNA repair DNA polymerase-driven viral DNA synthesis and virus-encoded noncoding RNA-regulated virus replication.

PI_NAMEs: QIU, JIANMING  (contact)

PROGRAM_OFFICER_NAME: ALARCON, RODOLFO M

PROJECT_TERMS: Acute;adeno-associated viral vector;Air;airway epithelium;Anti-viral Agents;ataxia telangiectasia mutated protein;Autonomous Replication;Capsid Proteins;Cell Cycle;Cell model;Cell Nucleus;Cells;Child;Circovirus;clinically relevant;Complex;delivery vehicle;Dependence;Dependovirus;DNA biosynthesis;DNA Damage;DNA Repair;DNA Replication Factor;DNA replication origin;DNA Viruses;DNA-Directed DNA Polymerase;DNA-PKcs;Double-Stranded RNA;Embryo;Epithelial Cells;Family;G2 Phase Arrest;Gene Delivery;Gene Expression;gene therapy;Genetic Transcription;Genome;Goals;Hela Cells;Helper Viruses;Human;In Vitro;in vivo;Infection;Interphase Cell;Kidney;Knowledge;KRP protein;Lead;Licensing;Liquid substance;Mediating;Modeling;mRNA Precursor;mRNA Translation;Nonstructural Protein;novel;Nucleotides;Open Reading Frames;Papillomavirus;Parvovirus;Parvovirus Infections;Pathogenicity;Pathway interactions;Phosphatidylinositols;Play;Polymerase;postmitotic;prevent;PRKR gene;Process;Production;Productivity;Property;protein expression;protein kinase R;Proteins;Proteomics;Rad30 protein;Recombinant adeno-associated virus (rAAV);recruit;Regulation;Respiratory Tract Infections;response;RNA metabolism;RNA Polymerase II;RNA Polymerase III;Role;S phase;Signal Transduction;Small RNA;Testing;therapeutic development;Transfection;Translations;Untranslated RNA;Viral;viral DNA;Viral Genes;Viral Genome;Viral Nonstructural Proteins;Virus Diseases;Virus Replication

PROJECT_TITLE: Viral and Host Determinants of Parvovirus Replication

STUDY_SECTION: VIRA

STUDY_SECTION_NAME: Virology - A Study Section[VIRA]


ORG_CITY: LEXINGTON

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: PROJECT NARRATIVE Colorectal cancer is the second most common cause of cancer deaths in the United States for men and women combined, and approximately 40% of patients with this disease will eventually die of tumor metastasis. This proposal aims to deepen our understanding of signaling pathways and immune evasion mechanisms in metastatic colorectal cancer by taking a novel approach for investigating mTOR signaling biology and its deregulation in the molecular pathogenesis of this invasive disease, with the goal of identifying selective translational regulators as novel cancer therapeutic targets. This knowledge is expected to lay a foundation for the development of novel therapies for metastatic colorectal cancer, a goal with clear and significant implications for public health.

PI_NAMEs: SHE, QING-BAI  (contact)

PROGRAM_OFFICER_NAME: AULT, GRACE S

PROJECT_TERMS: anti-PD-1;Binding Proteins;Biological Markers;Biology;cancer cell;Cancer Etiology;Cell Line;Cessation of life;Clinical;clinically relevant;colon cancer patients;Colorectal Cancer;colorectal cancer progression;colorectal cancer treatment;Dependence;Development;Disease;Down-Regulation;effective therapy;effectiveness evaluation;EIF4EBP1 gene;Environment;Epigenetic Process;experience;Fostering;Foundations;FRAP1 gene;Funding;Genes;genetic corepressor;Genetic Transcription;Goals;Immune Evasion;Immunity;Immunologic Surveillance;Immunologist;Immunotherapy;improved;in vivo;in vivo evaluation;inhibitor;inhibitor therapy;innovation;insight;Internal Ribosome Entry Site;kinase inhibitor;Knowledge;Left;Malignant Neoplasms;Mediating;men;Messenger RNA;metastatic colorectal;metastatic process;Molecular;Monoclonal Antibodies;mouse model;mRNA Translation;mTOR Inhibitor;Neoplasm Metastasis;novel;novel strategies;novel therapeutics;Oncogenic;Oncologist;Outcome Study;Pathogenesis;Pathologist;patient derived xenograft model;Patients;Phosphorylation;Phosphorylation Inhibition;Phosphotransferases;Polyribosomes;polysome profiling;Positioning Attribute;Process;Production;programmed cell death ligand 1;Property;Protein Biosynthesis;protein complex;Proteins;Public Health;recruit;Reporting;Research;Resistance;response;RNA;RNA Helicase;Role;Signal Pathway;Signal Transduction;silvestrol;Snails;T-Lymphocyte;targeted treatment;Testing;Therapeutic;therapeutic target;Transact;Translating;Translation Initiation;Translational Regulation;Translations;Treatment Efficacy;treatment response;tumor;tumor growth;Tumor Immunity;Tumor-Infiltrating Lymphocytes;United States;Woman;Work

PROJECT_TITLE: Targeting Translation Dependence in Colorectal Cancer Progression

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 1 Study Section[MCT1]


ADMINISTERING_IC: LM

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Childhood Leukemia;Clinical Research;Data Science;Genetics;Hematology;Human Genome;Networking and Information Technology R&D (NITRD);Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: Columbus

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Relevance In acute myeloid leukemia (AML), the advent of effective targeted therapies, intensiﬁed chemotherapy, and allo- geneic stem cell transplant have increased long-term survival such that a non-negligible subset of treated patients are cured; when cured subjects are present in a dataset, mixture cure models should be used in place of tra- ditional survival analytic techniques. We will develop novel methodologies and software for ﬁtting mixture cure models that accommodate modeling a high-dimensional feature space to enable researchers to identify molec- ular features from high-throughput genomic assays that are associated with likelihood of cure and time-to-event outcomes. Application of our methods will enhance existing AML risk stratiﬁcation systems used in daily clinical practice that determine treatment intensity and modality, identify potential therapeutic targets, and will be broadly applicable to the large number of genomic studies housed in NCBI's GEO portal that involve time-to-event analy- ses and a cured fraction.

PI_NAMEs: ARCHER, KELLIE J. (contact)

PROGRAM_OFFICER_NAME: DENNIS, ALLISON FRANCES

PROJECT_TERMS: Acute Myelocytic Leukemia;aged;American Cancer Society;Archives;Biological;Biological Assay;biomedical informatics;cancer type;Cessation of life;Characteristics;chemotherapy;Chronic;Clinical;clinical practice;Clinical Trials;Clip;Computer software;Cox Proportional Hazards Models;Data;Data Science;Data Set;Decision Making;Development;Diagnosis;Disease;Disease-Free Survival;Effectiveness;Event;experience;follow-up;Gene Expression;Genes;Genomics;hazard;high dimensionality;High-dimensional Modeling;improved;interest;Malignant Neoplasms;Methodology;Methods;Methylation;MicroRNAs;Modality;Modeling;Molecular;mRNA Expression;multidimensional data;Mutation;new therapeutic target;novel;Oncology;Outcome;Patients;Performance;Population Study;Predisposition;Probability;Process;Prognosis;prognostic;Property;Research;Research Personnel;Research Project Grants;Risk;risk stratification;RUNX1 gene;Sample Size;Sampling;Sampling Studies;semiparametric;simulation;software development;Statistical Methods;Stem cell transplant;Subgroup;survival outcome;survivorship;System;targeted treatment;Techniques;Technology;Testing;The Cancer Genome Atlas;Therapeutic;Therapeutic Agents;therapeutic target;Time;Tissue Sample;United States National Library of Medicine

PROJECT_TITLE: Penalized mixture cure models for identifying genomic features associated with outcome in acute myeloid leukemia


NIH_SPENDING_CATS: Biotechnology;Cancer;Colorectal Cancer;Digestive Diseases;Genetics;Lung;Lung Cancer

ORG_CITY: SAN FRANCISCO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Cancers driven by the oncogene KRAS are responsible for more than 70,000 deaths in the United States annually. Recently developed small molecules directly targeting the KRASG12C mutation have produced high response rates in patients with lung cancer, but only show limited benefit for patients with colorectal cancer. In this proposal, we study the signaling links between KRAS and the transcription factor CTNNB1 to understand the mechanisms of resistance to KRAS inhibition in colorectal cancer and find new therapeutic combinations.

PI_NAMEs: GORDAN, JOHN D (contact)

PROGRAM_OFFICER_NAME: CHEN, WEIWEI

PROJECT_TERMS: AXIN2 gene;BRAF gene;Cancer Biology;cancer cell;Cancer Etiology;cancer genomics;Cancer Model;Cell Culture Techniques;Cell Line;Cell Proliferation;Cells;Cessation of life;Cholangiocarcinoma;Clinical Data;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;colon cancer cell line;colon cancer patients;Colorectal;Colorectal Cancer;colorectal cancer treatment;Combined Modality Therapy;Complex;CRISPR interference;CTNNB1 gene;Data;Dependence;Development;Down-Regulation;Drug Combinations;Drug resistance;Engineering;Exposure to;Feedback;functional genomics;Gene Expression;Genes;Genetic Transcription;Genomic approach;genomic data;Human;improved;In Vitro;in vivo;Individual;Inferior;inhibitor;interest;knock-down;KRAS oncogenesis;KRAS2 gene;Laboratories;LGR5 gene;Link;Malignant neoplasm of lung;Malignant Neoplasms;Maps;Mediator;Melanoma;metastatic colorectal;Mitogen-Activated Protein Kinases;Modeling;mutant;Mutation;new technology;Non-Small-Cell Lung Carcinoma;novel strategies;novel therapeutics;Oncogenes;Oncogenic;Organoids;Outcome;Output;Pancreatic Ductal Adenocarcinoma;Pathway interactions;patient derived xenograft model;patient population;Patients;Pharmaceutical Preparations;Phosphotransferases;PIK3CA gene;Porcupines;programs;Proliferating;Proteomics;Recurrence;Refractory;Regimen;Regulation;Resistance;resistance mechanism;response;Role;Signal Transduction;Skin;small molecule;small molecule inhibitor;synergism;systemic toxicity;Tankyrase;targeted agent;targeted treatment;Testing;Tissues;tool;Toxic effect;transcription factor;Translations;treatment strategy;tumor;Tumor Cell Line;tumor growth;United States;WNT Signaling Pathway;Work

PROJECT_TITLE: Understanding intrinsic resistance to direct KRAS inhibition in colorectal cancers

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 2 Study Section[MCT2]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Genetics;Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: WORCESTER

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

ORG_STATE: MA

PHR: Program Narrative To understand pathogenic mechanisms of frontotemporal dementia and related disorders, we will use a combination of genetic, molecular and cellular approaches in mouse and Drosophila models as well as induced pluripotent stem cell models to perform a series of experiments. The proposed mechanistic studies will contribute to the development of therapeutic avenues for these insidious disorders.

PI_NAMEs: GAO, FEN-BIAO  (contact)

PROGRAM_OFFICER_NAME: SHEWMAKER, FRANK PAUL

PROJECT_TERMS: Address;Affect;Age;American;Amyotrophic Lateral Sclerosis;Anterior;Atrophic;Autophagocytosis;behavioral phenotyping;C9ORF72;Cell Line;Chromosome 3;Clinical;clinical phenotype;Clustered Regularly Interspaced Short Palindromic Repeats;Defect;Degradation Pathway;Dementia;Diagnosis;Disease;DNA Sequence Alteration;Drosophila genus;Endosomes;Engineering;Exhibits;experimental study;Family;Frontotemporal Dementia;frontotemporal lobar dementia amyotrophic lateral sclerosis;gene discovery;Genes;Genetic;Human;Impaired cognition;induced pluripotent stem cell;Induced pluripotent stem cell derived neurons;insight;interdisciplinary approach;Investigation;Language;Link;Membrane;Modeling;Molecular;Motor Neuron Disease;mouse model;Mus;Muscular Atrophy;mutant;Mutation;Nerve Degeneration;neural circuit;Neurodegenerative Disorders;neurodegenerative phenotype;Neuronal Differentiation;Neurons;new therapeutic target;Nonmuscle Myosin Type IIB;novel;Paralysed;Pathogenicity;Pathologic;Pathway interactions;Patients;Personality;Persons;prefrontal lobe;Process;Production;programs;Proteins;Recycling;Research;Series;Social Behavior;stem cell model;syntaxin 13;System;TBK1 gene;Temporal Lobe;Testing;therapeutic development;Therapeutic Intervention;therapeutic target;Toxic effect;Work

PROJECT_TITLE: Investigating Pathogenic Mechanisms of Frontotemporal Dementia Caused by Mutations in CHMP2B and TBK1

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Drug Abuse (NIDA only);HIV/AIDS;Immunization;Infectious Diseases;Networking and Information Technology R&D (NITRD);Prevention;Substance Misuse

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: PROJECT NARRATIVE This application to RFA-AI-19-002 is to continue as the statistical and data management center (SDMC) for the HIV Prevention Trials Network, which plans to 1) conduct a program of Phase 1-3 trials for testing new agents (antiretrovirals, broadly neutralizing monoclonal antibodies and multi-purpose technologies) for the prevention of HIV infection and 2) evaluate integrated strategy interventions that optimize use of proven efficacious prevention interventions tailored to specific populations at risk. The HPTN SDMC has faculty biostatisticians experienced in the design, conduct and analysis of global HIV prevention studies, who support the goals of HPTN research through leadership in statistical design, trial conduct and analysis, and development and implementation of innovative statistical methods as needed and motivated by HPTN scientific goals. The SDMC provides regulatory compliant data management functions for all HPTN trials, including electronic data capture directly from research sites, integration of laboratory specimens and assay results, and electronic participant reported outcomes.

PI_NAMEs: BROWN, ELIZABETH RENATA;DONNELL, DEBORAH J (contact)

PROGRAM_OFFICER_NAME: DEJLI, JAMAL

PROJECT_TERMS: active control;Address;AIDS prevention;analytical tool;Anti-Retroviral Agents;Behavioral;Behavioral Research;Biological Assay;Biological Products;budget impact;Characteristics;Clinical;Clinical Data;clinical research site;clinical trial analysis;Clinical Trials;cluster randomized design;control trial;cost effectiveness;cost efficient;cost estimate;Data;data acquisition;Data Coordinating Center;data management;Data Sources;design;Development;Drug Kinetics;Effectiveness;efficacy evaluation;efficacy trial;electronic data;electronic patient reported outcomes;Electronics;Epidemic;experience;Faculty;flexibility;Fred Hutchinson Cancer Research Center;Goals;Good Clinical Practice;Grant;HIV;HIV Infections;HIV prevention trials network;HIV Vaccine Trials Network;implementation study;improved;Individual;Information Technology;innovation;insight;Institution;Intervention;Laboratories;Leadership;Licensure;mathematical model;Methods;mobile application;Modality;Modeling;Monitor;neutralizing antibody;neutralizing monoclonal antibodies;New Agents;novel;novel strategies;operation;Opiate Addiction;Outcome;Participant;Pathway interactions;Phase;Population;Populations at Risk;Practice Management;Pregnancy;prevent;Prevention;preventive intervention;Process;programs;Public Health;Quality Control;Randomized;Randomized Controlled Clinical Trials;randomized placebo-controlled clinical trial;Reporting;Research;Risk;Safety;Scientific Advances and Accomplishments;Secure;Services;Site;Social Behavior;social stigma;Special Population;Specimen;standard of care;Statistical Methods;support network;Surveillance Program;System;Tablets;Technology;Testing;tool;transmission process;trial design;uptake

PROJECT_TITLE: SDMC: HIV Prevention Trials Network


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Pulmonary Fibrosis

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Project Narrative: Pulmonary fibrosis (PF) is a rare degenerative disease characterized by progressive lung stiffening, and punctuated by intermittent inflammatory episodes of unknown cause, termed “acute exacerbations”. Both genetic and environmental triggers are linked to disease pathogenesis and progression. Mutations of the epithelial cell-specific gene encoding for the surfactant protein-C (SP-C) are linked to clinical PF. To longitudinally examine endpoints relevant to PF, we developed a novel murine model that leverages the most common human mutation in the SP-C gene. The ubiquitous air pollutant ozone (O3) represents a major environmental contributor to disease exacerbation in vulnerable populations, including PF. Monocytes and macrophages are centrally involved in ozone toxicity and represent a predictor in PF severity. This project aims to functionally link monocyte/macrophage populations as central players in the exacerbation of PF resulting from ozone exposure of the SP-C mutant mice. Ultimately, we hope to identify a unique subset of monocyte- derived cells responsible for tissue damage, and thus develop a cell specific approach to improve health of PF patients.

PI_NAMEs: VENOSA, ALESSANDRO  (contact)

PROGRAM_OFFICER_NAME: NADADUR, SRIKANTH

PROJECT_TERMS: Acceleration;Acute;Air Pollutants;Bleomycin;Cells;Cessation of life;Chemical Injury;chemokine receptor;Clinical;clinically relevant;cytokine;Data;Degenerative Disorder;Dependence;Diagnosis;Disease;Ectopic Expression;effective therapy;Environmental Exposure;Environmental Risk Factor;Epidemiology;Epithelial Cells;Epithelium;fibrogenesis;Fibrosis;fibrotic lung;Flow Cytometry;fractalkine receptor;Future;Genes;Genetic;Genetic Transcription;Heterogeneity;Histologic;Histology;Human;improved;Infiltration;Inflammation;Inflammatory;Inflammatory Response;Inhalation;injured;Injury;Lesion;Life Expectancy;Link;Lung;Lung Diseases;lung health;Lung Transplantation;Macrophage;Mediator;Methods;Modeling;monocyte;mouse model;mutant;Mutant Strains Mice;Mutation;Myeloid Cell Activation;Myeloid Cells;novel;Oxidative Stress;Ozone;ozone exposure;Pathogenesis;Patients;Peripheral;pharmacologic;Phenotype;Population;Pre-Clinical Model;Predisposition;Property;Publishing;Pulmonary Fibrosis;Pulmonary Inflammation;Pulmonary Surfactant-Associated Protein C;recruit;response;Role;Severities;Signal Transduction;single-cell RNA sequencing;Sorting;System;Testing;Time;Tissues;Toxic effect;Toxic Environmental Substances;transcriptome sequencing;ventilation;Vulnerable Populations;Work

PROJECT_TITLE: Role of Surfactant Protein-C Mutation and Ozone Exposure in the Exacerbation of Pulmonary Fibrosis


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Diabetes;Emerging Infectious Diseases;Infectious Diseases;Nutrition;Obesity

ORG_CITY: NOVATO

ORG_NAME: BUCK INSTITUTE FOR RESEARCH ON AGING

PHR: PROJECT NARRATIVE Elevated insulin levels and low-grade inflammation are associated with insulin resistance, a hallmark of diet induced obesity, though little is known about how insulin and cellular insulin resistance influences immune cell function. Here, we show that insulin signaling in B cells of the immune system has critical effects on these cells’ functional capacity and inflammatory responses. Our proposed studies aim to better understand how insulin and its receptor impact B cells in health and during obesity related insulin resistance through study of the immunology and metabolism of B cell specific insulin receptor knock out mice.

PI_NAMEs: WINER, DAN  (contact)

PROGRAM_OFFICER_NAME: BASU, RAJATAVA

PROJECT_TERMS: 2019-nCoV;Activities of Daily Living;Acute;Adipose tissue;Adjuvant;Aging;Antibodies;Antibody Formation;Automobile Driving;B-Cell Activation;B-Lymphocytes;Behavior;Beta Cell;Binding;Blood Glucose;Brain;Cell Nucleus;Cell Physiology;Cell Survival;Cells;Cellular biology;Cellular Metabolic Process;Chronic;Communication;Coronavirus;COVID-19;COVID-19 risk;current pandemic;cytokine;Development;Diabetes Mellitus;Diet;diet-induced obesity;Disease;Docking;Environment;experimental study;Fatty acid glycerol esters;fighting;Frequencies;Functional disorder;Genes;Genetic Transcription;Genetically Engineered Mouse;global health;Glucose;Health;High Fat Diet;high risk;Homeostasis;Human;Hyperinsulinism;Immune;Immune system;Immune Targeting;Immunity;Immunoglobulin G;Immunologics;Immunology;immunoregulation;improved;Infection;Inflammation;Inflammatory;Inflammatory Response;Influenza;influenza infection;insight;Insulin;Insulin Receptor;Insulin Resistance;insulin signaling;Insulin Signaling Pathway;Knockout Mice;Knowledge;Link;Lipids;Liver;Longevity;Lung;Lung infections;Maps;Metabolic;Metabolism;mortality risk;mouse model;Mus;Muscle;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutics;Nuclear Translocation;Obese Mice;Obesity;obesogenic;Organism;Pathogenicity;Pathway interactions;Pattern;Persons;Play;Process;Production;Proliferating;Proteins;receptor;Receptor Signaling;Reporting;Research Proposals;Resistance;response;Risk Factors;Role;Severe Acute Respiratory Syndrome;Signal Pathway;Signal Transduction;Site;T-Lymphocyte;Time;Tissues;Toll-like receptors;Viral;Virus;Virus Diseases;Visceral;Work

PROJECT_TITLE: The B Cell Insulin Receptor in Health and in Insulin Resistance


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Childhood Injury;Disability Research;Networking and Information Technology R&D (NITRD);Neurosciences;Pediatric;Physical Injury - Accidents and Adverse Effects;Precision Medicine;Rehabilitation;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury;Unintentional Childhood Injury

PHR: Project narrative Traumatic brain injury (TBI) is a major public health issue, especially among children and adolescents, but current neuroimaging research tools have limited utility in this population due to unique issues related to development and TBI-related focal injury. Using multi-site data, we propose to develop a toolbox that addresses key limitations –– specifically, proper accounting of lesions and the use of age-appropriate templates –– and use that toolbox to identify factors associated with harmonized outcome measures. Our novel, comprehensive, cost-effective, easy-to-use, and well-supported workflow will lead to patient-specific profiles of pathology that are sensitive to patient heterogeneity and simultaneously allow for multi-site, harmonized analysis.

PI_NAMEs: DENNIS, EMILY LARSEN (contact);WILDE, ELISABETH A

PROGRAM_OFFICER_NAME: UMOH, NSINI ALEASE

PROJECT_TERMS: Accounting;Address;Adolescent;Adolescent Development;Adult;Age;Algorithms;analysis pipeline;Anatomy;Atrophic;Attention;Brain;Brain region;brain volume;Cause of Death;Characteristics;Child;Childhood;Childhood Injury;Chronic;Clinical;Clinical Data;clinically relevant;Cognitive;cohort;Communities;computational neuroscience;computer science;Consensus;cost effective;Craniocerebral Trauma;Data;Data Set;Developed Countries;Development;Diffuse;Diffusion;Diffusion Magnetic Resonance Imaging;disability;Disparate;Documentation;Education;Ensure;Exclusion;experience;Future;General Population;Genetic;Goals;Heterogeneity;high dimensionality;Image;Image Analysis;Imaging Device;improved;Incidence;Individual;injured;Injury;interest;International;Lesion;Link;Location;Long term disability;longitudinal analysis;Maps;Mathematics;Measures;Meta-Analysis;Modeling;Monitor;Morphology;morphometry;multidisciplinary;multimodality;Nerve Degeneration;neurodevelopment;neuroimaging;Neurology;Neuropsychology;novel;Outcome;Outcome Measure;outcome prediction;Pathology;patient population;patient subsets;Patients;Pattern;pediatric patients;Pediatric Radiology;pediatric traumatic brain injury;personalized medicine;Physical Medicine;Population;Positioning Attribute;Procedures;Process;Prognosis;psychologic;Public Health;Radiology Specialty;Recovery;Rehabilitation therapy;Research;Research Personnel;Resources;Running;Sample Size;Severities;sex;shape analysis;Site;Site Visit;software development;Statistical Data Interpretation;structural imaging;Subgroup;symposium;Symptoms;Technical Expertise;Techniques;Testing;therapy development;Thick;Time;tool;tractography;Traumatic Brain Injury;Validation;web site;Work;working group;Writing

PROJECT_TITLE: Personalized Profiles of Pathology in Pediatric Traumatic Brain Injury


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics

ORG_CITY: LOS ANGELES

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE  Histones are the main protein constituent of chromatin, the physiological relevant form of the genome, and function to compact the large eukaryotic genomes and regulate DNA-based processes such as gene expression. However, we have discovered that histones also functions as an enzyme to generate copper ions that can be used by the cell for many important processes and functions. We propose to investigate this novel role of histones in regulation of copper biology inside the cell that has important consequences for basic understanding of eukaryotic biology as well as human diseases such as cancer.

PI_NAMEs: KURDISTANI, SIAVASH  (contact)

PROGRAM_OFFICER_NAME: BARSKI, OLEG

PROJECT_TERMS: Active Sites;Archaea;Binding;Binding Sites;Biochemical;Biological;Biology;Catalysis;Catalytic Domain;Cell Nucleus;Cell Physiology;Cell Separation;Cells;chemical reaction;Chemistry;Chromatin;Chromatin Structure;cofactor;Complex;Copper;Coupled;CRISPR interference;CRISPR screen;CRISPR/Cas technology;cuprous ion;Cytoplasm;Data;deep sequencing;design;Destinations;Dialysis procedure;Dimensions;dimer;Disease;DNA;Electrons;Environment;enzyme activity;Enzymes;epigenetic regulation;epigenome;Eukaryota;Eukaryotic Cell;Evolution;Foundations;gain of function mutation;Gene Expression;Generations;Genes;Genetic;Genetic Screening;Genome;Histone H3;histone modification;Histones;Homeostasis;Human;human disease;Human Pathology;In Vitro;Ions;Link;Literature;loss of function;Malignant Neoplasms;Metabolism;Mitochondria;Mitochondrial Proteins;Modification;Molecular;Molecular Chaperones;N-terminal;NADP;Nerve Degeneration;novel;Nucleosomes;oxidation;Oxidoreductase;Pathway interactions;Physiological;Post-Translational Protein Processing;Process;protein complex;protein H(3);Proteins;Reaction;Recombinants;Reducing Agents;Regulation;Respiration;Role;Saccharomyces cerevisiae;screening;Side;Sodium Chloride;Structure;superoxide dismutase 1;System;Tail;Technology;Testing;Variant;Xenopus;yeast genetics;Yeasts

PROJECT_TITLE: Understanding the function of histone H3 as an oxidoreductase enzyme

STUDY_SECTION: MGB

STUDY_SECTION_NAME: Molecular Genetics B Study Section[MGB]


ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: Project Narrative: Despite extensive studies on relationships between diets and cancer risk, or many “balanced” nutrition therapies with hope to keep cancer patients healthy and strong for treatment and recovery, little is known about how dietary substances influence cancer and anti-cancer therapies. We thus constructed a “blood chemical (BC)” compound library, which contains circulating diet-derived nutrients including inorganics, organic metabolites, lipids, and dietary supplements, and performed screens to identify BCs that influence responses to immune checkpoint inhibitors (ICIs). In this proposal, we hypothesize that dietary trans-vaccenic acid (TVA), the predominant form of trans fatty acids in human milk, enhances activation of CD8+ T cells and consequent anti-tumor immunity.

PI_NAMEs: CHEN, JING  (contact)

PROGRAM_OFFICER_NAME: XI, DAN

PROJECT_TERMS: Acetoacetates;Acids;Adult;Agonist;Antibodies;Apoptosis;Attenuated;Binding;Binding Proteins;Blood;BRAF gene;Breast Cancer Cell;Butter;cancer infiltrating T cells;cancer initiation;Cancer Patient;cancer risk;cancer therapy;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cell Proliferation;Cell Survival;checkpoint therapy;Chemicals;chemotherapy;Chondroitin Sulfates;Clinical;Colon Carcinoma;Cyclic AMP;Cyclic AMP-Dependent Protein Kinases;Cyclic AMP-Responsive DNA-Binding Protein;Dairy Products;Data;design;Diet;diet and cancer;dietary;Dietary Proteins;dietary supplements;DNA sequencing;Eating;Elements;Enhancers;Epigenetic Process;exhaustion;Exhibits;extracellular;FFAR2 gene;Foundations;G-Protein-Coupled Receptors;Genetic Transcription;Hippophae;Human;Human Milk;Immune checkpoint inhibitor;Immune response;immunodeficiency;immunodeficient mouse model;immunogenic;Immunologics;Immunotherapy;improved;In Vitro;insight;interest;kethoxal;Ketone Bodies;Knockout Mice;Lewis lung carcinoma cell;Libraries;Link;Lipids;lung cancer cell;Malignant Neoplasms;MC38;Melanoma;meter;Milk;multidisciplinary;Mus;next generation sequencing;novel;Nude Mice;Nutrient;Nutrition Therapy;Oils;Outcome;Pathway interactions;PD-1/PD-L1;Periodicity;Population;programmed cell death ligand 1;programmed cell death protein 1;Recovery;Research Activity;response;Signal Transduction;Signaling Molecule;Single-Stranded DNA;Stereoisomer;Structure;T-Cell Activation;T-Cell Proliferation;T-Lymphocyte;Testing;Trans Fatty Acids;transcriptome;transcriptome sequencing;treatment response;tumor;tumor growth;Tumor Immunity;Tumor-Infiltrating Lymphocytes;Volatile Fatty Acids;Work;Xenograft procedure

PROJECT_TITLE: Dietary trans-vaccenic acid enhances anti-tumor immunity

STUDY_SECTION: CPSS

STUDY_SECTION_NAME: Cancer Prevention Study Section[CPSS]


ADMINISTERING_IC: MH

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Mental Illness;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Suicide;Suicide Prevention;Violence Research;Youth Violence

ORG_CITY: Chicago

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: PROJECT NARRATIVE Improving the implementation of suicide prevention practices in juvenile detention centers, centers that disproportionately serve African American and Black youth, may allow for earlier identification of youth at risk for suicide and the prevention of suicidal behaviors. The mentorship, training, and research activities proposed will result in a feasible, acceptable, and appropriate model of suicide prevention within juvenile detention centers. Developing independent investigators with the knowledge and skills to conduct this type of work is particularly important given that suicide prevention is a national priority, especially as it relates to juvenile justice-involved youth.

PI_NAMEs: RUDD, BRITTANY N (contact)

PROGRAM_OFFICER_NAME: SIMS, BELINDA ENITA

PROJECT_TERMS: Address;Adolescent;African American;Black race;brief intervention;career;career development;Caring;Case Manager;Chicago;Clinical;clinical center;Clinical Sciences;community engaged approach;Complement;Complex;Continuity of Patient Care;Data;Data Collection;design;detention center;Development;Discrimination;Early identification;effectiveness/implementation trial;Elements;Ensure;Environment;Equity;evidence base;Evidence based practice;experience;Faculty;feasibility testing;Feeling suicidal;Foundations;Funding;Future;Goals;health equity;Health equity research;High Prevalence;Hybrids;Illinois;implementation framework;implementation outcomes;implementation research;implementation strategy;improved;Individual;Infrastructure;interest;Intervention;Interview;Justice;juvenile justice system;K-Series Research Career Programs;Knowledge;Leadership;Legal;Letters;Lived experience;Mental Health;Mental Health Services;Mentorship;Methods;National Institute of Mental Health;Outcome;Pathway interactions;peer;Preparation;prevent;Prevention;prevention practice;Prevention Research;Procedures;Provider;Public Health;racism;recruit;reducing suicide;Reporting;Research;Research Activity;Research Methodology;Research Personnel;Resources;Risk;Risk Assessment;Safety;screening;Services;Severities;skills;social;social factors;Strategic Planning;structural determinants;suicidal;suicidal adolescent;suicidal behavior;suicidal risk;Suicide;Suicide attempt;suicide model;Suicide prevention;suicide rate;System;Training;Training Activity;Translational Research;Trust;United States National Institutes of Health;Universities;Voice;Work;young adult;Youth

PROJECT_TITLE: Optimizing the Zero Suicide Model for Juvenile Detention

STUDY_SECTION: SERV

STUDY_SECTION_NAME: Mental Health Services Study Section[SERV]


NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Data Science;Eye Disease and Disorders of Vision;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Neurosciences;Post-Traumatic Stress Disorder (PTSD);Prevention

ORG_CITY: BELMONT

ORG_NAME: MCLEAN HOSPITAL

PHR: PROJECT NARRATIVE/RELEVACE TO PUBLIC HEALTH Posttraumatic stress disorder (PTSD) carries significant emotional, financial, and social burdens for affected individuals and their families. Identification of neurobiological mechanisms that lead to PTSD development will facilitate the generation of novel predictive models and preventative interventions. The results of the proposed K01 are thus critical for the development of accurate neuroscience-based treatments for trauma and stress- related disorders.

PI_NAMEs: HARNETT, NATHANIEL G (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: Acute;Acute Post Traumatic Stress Disorder;acute stress;adverse outcome;Affect;Affective;Architecture;Arousal;Association Learning;Attention;Behavior;Behavioral Model;Big Data;Big Data Methods;Boston;Brain;career;Chronic;Chronic Phase;Chronic Post Traumatic Stress Disorder;Clinical;Clinical assessments;clinical training;clinical translation;Cognitive;cognitive neuroscience;cohort;Computer Models;conditioning;Coupling;Data;Data Analyses;Data Collection;data management;Development;Diffusion Magnetic Resonance Imaging;Dimensions;Discrimination;Early-life trauma;Emotional;Environment;Exposure to;Family;Functional disorder;Functional Magnetic Resonance Imaging;Future;Generations;Goals;Hospitals;Imaging Techniques;improved;Individual;individual variation;innovation;insight;Institution;Investigation;K-Series Research Career Programs;large datasets;large-scale imaging data;Magnetic Resonance Imaging;Maps;Mediating;medical schools;Memory;Mentors;Methods;Modeling;multimodal data;multimodal fusion;multimodality;National Institute of Mental Health;Negative Valence;neural;neural circuit;neurobiological mechanism;Neurobiology;neuroimaging;neurophysiology;Neurosciences;Neurosciences Research;novel;Pathway interactions;Perception;Population;Post-Traumatic Stress Disorders;predictive modeling;Predisposition;Prevention;Prevention strategy;preventive intervention;Procedures;Process;programs;Psychiatry;Public Health;Reaction Time;Reproducibility;Research;Research Design;Research Domain Criteria;Research Personnel;Research Project Grants;Research Training;Resources;response;Rest;Risk;Risk Factors;Sensory;Site;skills;social;Standardization;Statistical Data Interpretation;Stimulus;stress reactivity;stress related disorder;stress symptom;Symptoms;System;Training;Training Programs;Trauma;trauma exposure;traumatic event;traumatic stress;United States National Institutes of Health;ventral visual stream;Visual;Visual attention;Visual Pathways;Visual Perception;visual processing;visual search;visual stimulus;Visual System;Work

PROJECT_TITLE: Multimodal characterization of affective visual processing in the early aftermath of trauma

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


NIH_SPENDING_CATS: Aging;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Kidney Disease;Patient Safety;Prevention

ORG_CITY: CORAL GABLES

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: Project Narrative/Public Health Relevance Statement Diabetes management in patients with ESRD represent a challenge for clinicians and patients. These patients are exposed to wide glycemic exposures, and high risk for hypoglycemia and glycemic variability. Current glucose control measures lack accuracy and validation in ESRD patients. Continuous glucose monitoring (CGM) provides a comprehensive, real-time 24-hours glucose profile, but no prior study has included ESRD patients. The proposed research intends to fill this critical knowledge gap by testing a new strategy with novel factory-calibrated CGMs.

PI_NAMEs: GALINDO, RODOLFO  (contact)

PROGRAM_OFFICER_NAME: ARREAZA-RUBIN, GUILLERMO

PROJECT_TERMS: Advisory Committees;Affect;Arrhythmia;base;Binding;Bioinformatics;Biometry;Blinded;Blood capillaries;Blood Glucose;blood glucose regulation;Calibration;career;career development;Caring;Clinical Research;cohort;Comparative Study;Continuous Glucose Monitor;Data;Databases;Detection;Development Plans;diabetes management;Diabetes Mellitus;Diabetic Nephropathy;Dialysis patients;Dialysis procedure;Doctor of Philosophy;Dose;efficacy evaluation;Emergency department visit;End stage renal failure;experience;Exposure to;F2-Isoprostanes;Funding;Future;Glucose;glucose metabolism;glucose monitor;glycemic control;Heat-Shock Proteins 70;Hemodialysis;high risk;Home;Hospital Costs;Hospitalization;Hour;Hyperglycemia;Hypoglycemia;Hypoglycemic Agents;improved;Inflammation Mediators;Inflammatory;innovation;insight;Institution;Insulin;insulin sensitivity;Interleukin-6;Intervention;Knowledge;Length of Stay;Longitudinal cohort study;Measures;Mentors;Mentorship;Monitor;monitoring device;Morbidity - disease rate;mortality;multidisciplinary;Non-Insulin-Dependent Diabetes Mellitus;novel;nutrition;Outcome;Oxidative Stress;patient oriented;Patient Participation;Patients;Pattern;Pharmaceutical Preparations;Phase;Plasma;point of care;Population;Prevalence;prevent;public health relevance;randomized trial;Renal clearance function;Reporting;Research;Research Methodology;Resources;Risk;Role;Seizures;standard of care;Stroke;sudden cardiac death;Sulfonylurea Compounds;System;Technology;Testing;Therapeutic;Time;Training;translational study;treatment as usual;trend;United States National Institutes of Health;Universities;Validation;Venous

PROJECT_TITLE: Use of Continuous Glucose Monitoring (CGM) in End-Stage Renal Disease(ESRD) Patients with Type 2 Diabetes

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Dental, Oral, and Craniofacial Disease;Digestive Diseases

ORG_DEPT: PSYCHOLOGY

PHR: PROJECT NARRATIVE Swallowing disorders are directly linked to aging and contribute to multiple other health care problems potentially affecting more than 70 million aging Americans. The proposed Dysphagia: In Search of a Unified Definition for the Aging Population conference will bring together expert scientists, researchers, and stakeholders in the arena of dysphagia and aging to formally synthesize, discuss, and agree upon an accepted definition for dysphagia across the domains of screening, diagnosis, treatment, management and ongoing care. Requested funding from this R13 award will support attendance of discussants in aging and dysphagia, stakeholders, under-represented junior and minority scientists, and support associated conference service costs, leading to uniformity in the definition of dysphagia for academics, research, public policy, and health care landscape to improve the care of the aging population.

PI_NAMEs: SUITER, DEBRA M (contact)

PROGRAM_OFFICER_NAME: SALIVE, MARCEL

PROJECT_TERMS: Address;Adherence;Adult;Advocacy;Affect;Aging;aging population;Agreement;American;Area;Automobile Driving;Award;Biomedical Engineering;career;Caregivers;Caring;Childhood;Clinical;Code;Collaborations;Communication;Communities;Consensus;cost;Critical Care;Data;Decision Making;Dedications;Deglutition;Deglutition Disorders;Dehydration;Diagnosis;diagnostic accuracy;Discipline;Discipline of Nursing;Disease;Elderly;Etiology;Evaluation;evidence base;experience;falls;Family;Fostering;frailty;Funding;Gastroenterology;Gerontology;Goals;Government Officials;Guidelines;Health;Health Care Costs;health care settings;Healthcare;Hospitalization;improved;Incidence;Individual;Infrastructure;Institution;interest;International;Intervention;Journals;Knowledge;lectures;Letters;Link;Literature;Lobbying;Malnutrition;Medical;Medical Records;medical specialties;member;Methods;Minority Groups;minority scientist;Modeling;Multi-site clinical study;multidisciplinary;Names;National Institute on Aging;nutrition;older adult;Oral;Otolaryngology;Outcome Measure;patient population;Patients;Peer Review;Philosophy;Physiological;Pneumonia;Policies;Policy Maker;Population;posters;Prevalence;Prevention;psychosocial;Public Health;Public Policy;Publications;Pulmonology;Quality of life;Research;Research Personnel;Resources;Science;Scientist;screening;Services;Speech-Language Pathology;symposium;systematic review;targeted treatment;Testing;Third-Party Payer;Underrepresented Minority;United States National Institutes of Health;Validation;Work

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development for Established Investigators and Conference Grants Study Section[AGCD-4]


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Kidney Disease;Patient Safety;Prevention;Urologic Diseases

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: Project Narrative: We propose novel methods and algorithms to develop personalized dynamic risk prediction and to identify modifiable risk factors for kidney stone progression. The proposed methods will be evaluated and validated with multiple real-world datasets from kidney stone research consortia. The success of this project will fill the knowledge gap of kidney stone disease progression, and lead to a predictive toolbox to inform clinicians on the risk of stone disease progression, thereby facilitating timely clinical decision-making and effective implementation of targeted strategies to prevent or reduce stone disease progression.

PI_NAMEs: LIU, YU-LUN  (contact)

PROGRAM_OFFICER_NAME: KIRKALI, ZIYA

PROJECT_TERMS: Accounting;Affect;Algorithms;Characteristics;Chronic Kidney Failure;clinical decision-making;clinical practice;clinical predictors;Clinical Research;clinical research site;Clinical Trials;cohort;Collection;Competence;Computational algorithm;Computer software;Data;data registry;Data Set;Decision Making;Disease;Disease Progression;Electronic Health Record;End stage renal failure;Enrollment;Event;experience;Foundations;Funding;Goals;Health Care Costs;healthcare burden;high risk;Hour;Hydration status;Joints;Kidney Calculi;Kidney Diseases;Knowledge;Link;Medical;men;Metabolic;Metabolism;Methodology;Methods;Minerals;Modeling;modifiable risk;Morbidity - disease rate;mortality;National Institute of Diabetes and Digestive and Kidney Diseases;novel;Outcome;Pain;Participant;Patients;Pennsylvania;Pharmaceutical Preparations;Physicians;Population;predictive modeling;predictive tools;Prevalence;prevent;Prevention;Prevention strategy;Public Health;Qualifying;Recording of previous events;Records;Recurrence;Regimen;Registries;Research;response;Risk;Risk Factors;risk prediction;risk prediction model;risk stratification;Sampling;Science;software development;success;Time;tool;United States;Universities;University Hospitals;Urinary Calculi;Urine;Validation;Woman;Work

PROJECT_TITLE: Novel evidence-accumulation-driven methods for characterizing kidney stone progression

STUDY_SECTION: CDMA

STUDY_SECTION_NAME: Clinical Data Management and Analysis Study Section[CDMA]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Prevention;Social Determinants of Health

ORG_CITY: BLOOMINGTON

ORG_NAME: TRUSTEES OF INDIANA UNIVERSITY

ORG_STATE: IN

PHR: The experience of daily stressors can accelerate cognitive decline and increase the risk of heart disease, depression, and other debilitating chronic illnesses – especially for those who are in underrepresented minority groups or live in low-income areas. In this project, we measure the daily stressors of mid-life (aged 50-64) adults using mobile phones, which allows us to better understand where and how stressors happen as people go about their daily lives. This knowledge can be used to develop community or psychological interventions to address environmental stressors and promote healthy aging.

PI_NAMEs: JORDAN, EVAN  (contact)

PROGRAM_OFFICER_NAME: HOOKER, EMILY DIANE

PROJECT_TERMS: Acceleration;Address;Adult;age group;aged;Area;Arousal;Behavioral Model;Black Populations;Cellular Phone;Characteristics;Chronic Disease;cognitive function;Communities;community intervention;Crime;Custom;Data;Ecological momentary assessment;Elements;Enrollment;Environment;environmental stressor;Equipment and supply inventories;ethnic minority;experience;Exposure to;forest;Generations;Global Positioning System;Green space;Health;Health Promotion;healthy aging;heart disease risk;Heart Rate;Home;Image;Impaired cognition;Individual;Inequality;Intervention;Knowledge;land use;Life;Link;Location;Low income;Measurement;Measures;Mental Depression;Methods;middle age;mindfulness intervention;Minority Groups;Nature;Neighborhoods;new technology;novel;Outcome;Participant;Patient Self-Report;perceived stress;Personal Satisfaction;Persons;Physical activity;physically handicapped;Play;Population;Poverty;psychologic;Race;racial minority;Randomized;Reporting;Research Design;Role;rural environment;rural setting;Severities;smart watch;smartphone application;Socioeconomic Status;spatiotemporal;stem;Stress;stress management;stress reduction;Stressful Event;stressor;suburb;Surveys;Technology;Text;therapy design;therapy development;Time;tool;Underrepresented Minority;United States;United States National Institutes of Health;urban setting;Violence;Work

PROJECT_TITLE: Examining the daily stress of mid-life adults in the built and natural environment

STUDY_SECTION: CIHB

STUDY_SECTION_NAME: Community Influences on Health Behavior Study Section[CIHB]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cardiovascular;Epilepsy;Neurodegenerative;Neurosciences

ORG_CITY: BOSTON

ORG_DEPT: NEUROSCIENCES

ORG_NAME: TUFTS UNIVERSITY BOSTON

PHR: Project Narrative We recently discovered that mice with hyperactive stress circuits exhibit an increased incidence of SUDEP. Given that both stress and SUDEP link to disruption of central circuits responsible for the regulation of cardiorespiratory function, this application will interrogate a potential, novel pathophysiological mechanisms contributing to SUDEP involving hyperactive stress circuits and exaggerated cardiac vagal output. This application has the potential to uncover a novel mechanism contributing to SUDEP risk, which may also be relevant to other forms of sudden death.

PI_NAMEs: MAGUIRE, JAMIE LYNN (contact)

PROGRAM_OFFICER_NAME: LEENDERS, MIRIAM

PROJECT_TERMS: Apical;Apnea;Autonomic Dysfunction;Behavioral;Biological Markers;Brain Stem;Cardiac;Cardiovascular system;Chronic;Chronic stress;comorbidity;Corticotropin-Releasing Hormone;Data;Electrophysiology (science);Environmental Risk Factor;Epilepsy;Exhibits;Functional disorder;Genetic;genetic approach;Genetically Engineered Mouse;Heart Arrest;Heart Rate;Hyperactivity;Hypothalamic structure;hypothalamic-pituitary-adrenal axis;Impairment;Incidence;Injections;innovation;Laboratories;Link;Lung;Mediating;Methods;Modeling;Motor;Motor output;Mus;Neurons;Neurosecretory Systems;novel;Nucleus solitarius;Output;paraventricular nucleus;Pathway interactions;Patients;pharmacologic;Physiology;Radio;Reflex action;Regulation;respiratory;response;Risk;Role;Seizures;Sensory;Stress;Sudden Death;sudden unexpected death in epilepsy;Tachycardia;Telemetry;Testing;Therapeutic;Whole Body Plethysmography

PROJECT_TITLE: CRH Dysregulation of Brainstem Autonomic Circuits Increases SUDEP Risk


NIH_SPENDING_CATS: Hematology;Kidney Disease;Pain Research;Rare Diseases;Sickle Cell Disease

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Kidney disorders including acute kidney injury (AKI), chronic kidney disease (CKD) and end-stage renal diseases (ESRD) are prevalent in sickle cell disease (SCD) and account for significant morbidity and mortality in this patient population. Incidences of AKI, compelling risk factors for CKD and ESRD, are major clinical concerns among SCD patients hospitalized for acute hemolytic crisis. Enhanced clearance of excess circulating heme to the kidneys during hemolysis promotes clinically relevant AKI in murine model of SCD. The role of altered heme scavenging system, clearing free circulating heme, in the pathogenesis of AKI is unknown. This project will determine i) the association of two heme scavengers, hemopexin and alpha-1-microglobulin, with AKI in SCD patients, ii) the mechanism by which heme regulates the biosynthesis of heme scavengers, and iii) the putative pathway that impairs heme degradation by heme oxygensase-1 in SCD kidneys. This proposal will determine if ratio of plasma heme scavengers’ concentration serves as a prognostic risk factor for AKI in SCD. The results of this proposal will also identify specific intermediate therapeutic targets to block AKI pathogenesis in order to improve adverse outcomes of kidney injuries in SCD.

PI_NAMEs: GHOSH, SAMIT  (contact)

PROGRAM_OFFICER_NAME: SADUSKY, ANNA BURKART

PROJECT_TERMS: Acceleration;Acute;acute chest syndrome;Acute Renal Failure with Renal Papillary Necrosis;adverse outcome;alpha-1-microglobulin;Anabolism;Apoptosis;attenuation;Binding;biobank;Biological Availability;Biological Markers;Caspase;Cell Death;Cells;Cessation of life;Characteristics;Chronic;Chronic Kidney Failure;Clinical;clinical risk;clinically relevant;cohort;Data;Development;Drops;End stage renal failure;Epithelial Cells;Epithelium;Event;exhaust;experimental study;Exposure to;extracellular;Genes;Genetic Diseases;Heme;heme 1;heme biosynthesis;heme oxygenase-1;Hemin;Hemoglobin;Hemolysis;Hemopexin;Hepatic;hepatic nuclear factor 1;HNF4A gene;Hospitalization;Human;Impairment;improved;In Vitro;in vivo;Incidence;Individual;Infusion procedures;Injury to Kidney;intravenous injection;Kidney;Kidney Diseases;Knock-out;knockout gene;Knockout Mice;Liver;Mediating;Mitochondria;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;Mouse Strains;Mus;novel;overexpression;Pathogenesis;Pathway interactions;patient population;Patients;Phenocopy;Plasma;Production;prognostic;promoter;prospective;Proteins;Reactive Oxygen Species;Refractory;Renal clearance function;Research;Risk;Risk Factors;Role;Sampling;Serum;Sickle Cell Anemia;sickling;Source;System;targeted treatment;Testing;therapeutic target;Toxic effect;transcription factor;Tubular formation;Urine;vaso-occlusive pain;virtual

PROJECT_TITLE: Molecular and Cellular Pathogenesis of Kidney Disease in Sickle Cell Disorders

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Immunotherapy;Women's Health Research

ORG_CITY: BUFFALO

ORG_NAME: ROSWELL PARK CANCER INSTITUTE CORP

ORG_STATE: NY

PHR: Project Narrative Immunosuppressive myeloid cells are recognized as a significant barrier to the efficacy of immunotherapies in cancer patients although their precise site of action is not fully understood. Our laboratory discovered that myeloid cells interact with anticancer immune cells directly within the blood, forming previously unrecognized ‘circulating myeloid cell (CMC) clusters’ that we propose instigate global immune suppression. Our proposed research has the potential to define CMC clusters as a novel mechanism of immune suppression, thereby implicating these cellular conjugates as a blood-based biomarker to guide treatment decisions to improve patient responses to anticancer agents.

PI_NAMEs: ABRAMS, SCOTT I.;EVANS, SHARON S (contact)

PROGRAM_OFFICER_NAME: KUO, LILLIAN S

PROJECT_TERMS: Active Sites;adaptive immunity;Address;Adhesives;Adoptive Cell Transfers;Adoptive Transfer;Advanced Malignant Neoplasm;Agonist;anti-cancer;Antibodies;Antigens;Antineoplastic Agents;Apoptosis;Biological Markers;Blood;Blood flow;blood-based biomarker;Breast Cancer Model;Breast Cancer Patient;Breast Melanoma;cancer immunotherapy;Cancer Patient;cancer therapy;CD3 Antigens;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Communication;Cells;Cellular immunotherapy;checkpoint inhibition;chemokine;Clinical;Clinical Trials;clinically relevant;Cluster Analysis;Coculture Techniques;Complex;cytotoxic CD8 T cells;Cytotoxic T-Lymphocytes;Data;defined contribution;Destinations;Disabling;Disseminated Malignant Neoplasm;Effector Cell;Equilibrium;Exclusion;fitness;Foundations;Genetic;genetic approach;Home;Homing;Human;human cancer mouse model;ICAM2 gene;Immune;Immune checkpoint inhibitor;Immunity;Immunosuppression;Immunotherapeutic agent;Immunotherapy;improved;in vivo;insight;Integrins;Intercellular adhesion molecule 1;interest;L-Selectin;Laboratories;Leukocytes;Ligands;Liver X Receptor;lymph nodes;Lymphocyte;Lymphocyte Homing Receptors;lymphoid organ;Malignant Neoplasms;Mammary Neoplasms;Mediating;Melanoma;Melanoma patient;Memory;Metastatic breast cancer;microscopic imaging;Modeling;mouse model;Mus;Myeloid Cell Suppression;Myeloid Cells;Myeloid-derived suppressor cells;Natural Immunity;Natural Killer Cells;new therapeutic target;novel;Outcome;patient response;Patient Selection;Patients;Population;Pre-Clinical Model;preconditioning;predicting response;predictive signature;prevent;prognostic indicator;prognostication;programs;Publishing;receptor;recruit;Regimen;Research;Residual state;Resistance;resistance mechanism;response;Site;Solid;Solid Neoplasm;Spleen;Splenectomy;stem cells;Structure;Suppressor-Effector T-Lymphocytes;System;T cell response;T cell therapy;T memory cell;T-Lymphocyte;Testing;Therapeutic;therapy resistant;Tissues;trafficking;Travel;Treatment Efficacy;tumor;Tumor Immunity;tumor microenvironment;Work

PROJECT_TITLE: Impact of Circulating Myeloid Cell Clusters on Anti-Tumor Immunity

STUDY_SECTION: CII

STUDY_SECTION_NAME: Cancer Immunopathology and Immunotherapy Study Section[CII]


NIH_SPENDING_CATS: Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Neurosciences;Physical Activity;Physical Injury - Accidents and Adverse Effects;Physical Rehabilitation;Rehabilitation;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_DEPT: NEUROSURGERY

PHR: Narrative We hypothesize that the period of convalescence after TBI is caused by the loss of the capacity of brain cells to metabolize the energy necessary to sustain brain plasticity and function. We will determine the capacity of a natural BDNF agonist to restore energy balance with subsequent enhancement of physical rehabilitation outcome after concussive brain injury. We will combine functional brain imaging, molecular assessments of synaptic plasticity and metabolism, and behavior to assess the efficacy of the interventions.

PI_NAMEs: GOMEZ-PINILLA, FERNANDO  (contact);HARRIS, NEIL

PROGRAM_OFFICER_NAME: AWWAD, HIBAH OMAR

PROJECT_TERMS: Acute;Adult;Agonist;Animals;anxiety-like behavior;Atrophic;Behavior;Behavioral;behavioral outcome;Bioenergetics;Brain;brain cell;Brain Concussion;Brain imaging;Brain Injuries;brain metabolism;Brain-Derived Neurotrophic Factor;Cells;Cellular Metabolic Process;Cerebrovascular Circulation;Chronic;Clinical;Cognitive;cognitive function;Convalescence;Data;Dependence;Diffusion;Discrimination;Dose;Early Intervention;efficacy evaluation;Elements;energy balance;Exercise;Exercise Physiology;experience;experimental study;Female;Flavonoids;Functional Magnetic Resonance Imaging;functional outcomes;gain of function;Hippocampus;Image;Impairment;improved;improved outcome;in vivo;indexing;Injury;insight;Institution;Intervention;Learning;limb injury;Link;longitudinal analysis;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;male;Maps;Measures;Memory;metabolic abnormality assessment;metabolic depression;Metabolic Marker;Metabolism;Methods;Modeling;Molecular;Monitor;Motor Cortex;Network-based;neural circuit;neuronal circuitry;neuronal survival;Neurons;Neurotrophic Tyrosine Kinase Receptor Type 2;novel;Outcome;Pathologic;Pathology;patient engagement;Patients;pharmacologic;Physical activity;Physical Rehabilitation;Play;pre-clinical;protein biomarkers;Rattus;Recovery;Recovery of Function;Rehabilitation Outcome;Rehabilitation therapy;Reporting;Rest;Severities;small molecule;Soldier;success;Swelling;Synapses;synaptic function;Synaptic plasticity;synergism;TBI Patients;Testing;Therapeutic;Time;Tissues;Training;Traumatic Brain Injury;Traumatic Brain Injury recovery;Treatment Efficacy

PROJECT_TITLE: Strategy to Potentiate Rehabilitation after TBI

STUDY_SECTION: BINP

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Assistive Technology;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Hearing Loss;Neurosciences;Pediatric;Prevention;Rehabilitation

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: Project Narrative: This proposal seeks partial support for a biennial international conference on basic research on cochlear implants and other forms of prosthetic hearing. This conference provides a unique forum for scientists and engineers to share their latest work and brainstorm about future promising directions in research.

PI_NAMEs: RUBINSTEIN, JAY T. (contact)

PROGRAM_OFFICER_NAME: KING, KELLY ANNE

PROJECT_TERMS: Acoustics;Adult;Age;Atmosphere;Auditory;Auditory Brain Stem Implants;Auditory Prosthesis;Basic Science;Cellular biology;Child;clinical application;Cochlear Implants;Cochlear Nerve;Cochlear nucleus;Cognition;Collaborations;Communication;Communities;comorbidity;congenital deafness;deaf;design;Devices;Discipline;effective therapy;Electrodes;Engineering;Environment;Equity;Esthesia;Face;Fostering;Future;Goals;harassment;hard of hearing;Hearing;Hearing Aids;hearing impairment;Hour;Implant;improved;Individual;interdisciplinary collaboration;International;Language Development;Length;Linguistics;Location;materials science;meetings;member;Modification;Music;neural prosthesis;Noise;Organizational Models;Participant;patient population;Patients;Perception;Performance;Physiology;Population;programs;Research;Research Personnel;Residual state;Schedule;Science;Scientist;Series;signal processing;Social Network;sound;Speech;Speech Development;Speech Perception;Structure;symposium;Time;Variant;Vestibular loss;vestibular system;Work

PROJECT_TITLE: Conference on Implantable Auditory Prostheses

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Prevention;Social Determinants of Health

ORG_CITY: BALTIMORE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Food pantries face many challenges, including recruitment and training of staff/volunteers, communications with staff/volunteers and clients, providing client choice, and emergency preparedness. We will develop, implement, and evaluate the Support Application for Food Pantries (SAFPAS), a mobile application to address these concerns under normal and emergency operations, and assess its impact on 20 Baltimore food pantries, and on the healthiness of foods received by 360 food pantry clients using a randomized controlled trial design. If successful, the tested and refined app will support local food assistance programs throughout the United States.

PI_NAMEs: BARNETT, DANIEL JEREMY;GITTELSOHN, JOEL  (contact)

PROGRAM_OFFICER_NAME: BROWN, ALISON GWENDOLYN MARY

PROJECT_TERMS: Address;American;Baltimore;base;Behavior;Beverages;Cardiovascular Diseases;Chronic Disease;Cities;Client;Clinical Trials;Communication;Communities;Consumption;COVID-19 pandemic;Data;Decentralization;Diet;digital;digital applications;Education;Effectiveness;emergency preparedness;Emergency response;Emergency Situation;experience;Face;Feedback;feeding;Food;Food Assistance Programs;food environment;food insecurity;food quality;Food Safety;food security;Food Supply;fruits and vegetables;Future;Goals;Health;Health Food;Healthy Eating;high risk;Human Resources;Impact evaluation;improved;indexing;Individual;Infrastructure;Institution;instrument;Intervention;Intervention Trial;Knowledge;Link;Low income;Malignant Neoplasms;Maryland;Measures;meetings;mobile application;Modeling;National Heart, Lung, and Blood Institute;Non-Insulin-Dependent Diabetes Mellitus;nutrition education;Obesity;older adult;operation;Outcome;pandemic disease;Persons;Pilot Projects;pilot trial;Policies;poor health outcome;post intervention;Prevention program;primary outcome;process evaluation;Protocols documentation;Psychosocial Factor;Randomized;Randomized, Controlled Trials;Readiness;recruit;Research;Resources;response;Restaurants;Risk;Safety;Sampling;satisfaction;Schedule;Self Efficacy;Services;severe COVID-19;statistics;successful intervention;Surveys;System;Testing;Time;Training;trial design;United States;uptake;Urban Community;urban setting;volunteer;Work

PROJECT_TITLE: Developing a Support Application for Food Pantries (SAFPAS) to Improve Client Access to Healthy Foods & Enhance Emergency Preparedness

STUDY_SECTION: SSPT

STUDY_SECTION_NAME: NHLBI Single-Site and Pilot Clinical Trials Study Section[SSPT(OA)]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Emergency Care;Health Services;Heart Disease

ORG_DEPT: EMERGENCY MEDICINE

PHR: PROJECT NARRATIVE Annually, over 356,000 Americans have cardia arrest at outside of hospitals, and emergency medical services (EMS) provides crucial care such as airway management and medication administration. However, the optimal timing of these EMS resuscitation interventions remains unclear. This proposal will identify the optimal timing of the resuscitation interventions at EMS systems that impacts survival after out-of-hospital cardiac arrest.

PI_NAMEs: OKUBO, MASASHI  (contact)

PROGRAM_OFFICER_NAME: NATARAJAN, ARUNA R

PROJECT_TERMS: Address;Adult;Affect;American;American Heart Association;Applications Grants;Canada;Cardiopulmonary Resuscitation;cardiovascular emergency;care systems;Caring;Childhood;Clinical;cohort;Consensus;Data;Death Rate;Emergency medical service;Epinephrine;Event;functional disability;functional outcomes;functional status;Future;Goals;Grant;Guidelines;Hospitals;improved outcome;Individual;International;Intervention;Intratracheal Intubation;Knowledge;Life;Link;Masks;Medical;medication administration;Methodology;Modeling;mortality;out-of-hospital cardiac arrest;Outcome;Patient-Focused Outcomes;Patients;pediatric patients;Play;Population;Pre-hospitalization care;Principal Investigator;Probability;Public Health;Recommendation;Registries;Research;Resuscitation;Risk;Role;Science;secondary analysis;stomach cardia;Survival Analysis;survival outcome;System;systematic review;Techniques;Time;Time Management;time use;United States;ventilation

PROJECT_TITLE: Optimal timing of prehospital advanced airway management and epinephrine administration for out-of-hospital cardiac arrest

STUDY_SECTION: ODHS

STUDY_SECTION_NAME: Organization and Delivery of Health Services Study Section[ODHS]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE The annual burden of digestive diseases is considerable, exceeding $135 billion. The Center for Gastrointestinal Biology and Disease promotes multidisciplinary research to improve the understanding of the biology, physiology and epidemiology of digestive diseases. The expectation is that this knowledge will be translated into new strategies for prevention and treatment that will lower the burden of digestive diseases.

PI_NAMEs: SANDLER, ROBERT S. (contact)

PROGRAM_OFFICER_NAME: SERRANO, KATRINA JANE

PROJECT_TERMS: Acceleration;advanced analytics;Age;Animal Model;Animals;Area;base;biological research;Biology;Biometry;career;Climate;Clinical;Clinical Research;Collaborations;Communication;Core Facility;cost;Dedications;Development;Digestive System Disorders;Direct Costs;Discipline;Disease;Educational workshop;environmental enrichment for laboratory animals;Epidemiology;expectation;Expenditure;Faculty;Fostering;Funding;gastrointestinal;Gastrointestinal Diseases;Gnotobiotic;Grant;Health Expenditures;Homeostasis;hospital readmission;Hospitalization;improved;injury and repair;Interdisciplinary Study;International;Knowledge;Laboratory Animals;lectures;Liver diseases;member;microbiome;Mission;multidisciplinary;new technology;Pancreatic Diseases;Physiology;Population;Prevention strategy;Productivity;programs;Publications;Regenerative Medicine;repaired;Research;Research Personnel;Research Support;Scientist;Services;Training;Training Programs;Translating;Translational Research;Visit


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Cervical Cancer;Clinical Research;Genetics;Human Genome;Precision Medicine;Radiation Oncology;Women's Health Research

ORG_CITY: HOUSTON

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: Project Narrative This project aims to validate potential targets for chemoradiation sensitization in patients with cervical cancer undergoing chemoradiation for cure. This will be accomplished by testing previously identified potential targets in cervical cancer cell lines and organoid models and by computationally validating mutations that expand during CRT in patients undergoing treatment. This proposal uses a novel, non-invasive swab-based biopsy method to collect serial data without harm or discomfort to patients, which is the first approach in cervical cancer.

PI_NAMEs: COLBERT, LAUREN ELIZABETH (contact)

PROGRAM_OFFICER_NAME: PRASANNA, PAT G

PROJECT_TERMS: Address;Aftercare;biobank;Biological Models;Biopsy;Blood Banks;Cancer cell line;Cancer Patient;Candidate Disease Gene;candidate validation;Cause of Death;cell bank;Cell Line;Cervical;chemoradiation;Chemotherapy and/or radiation;Clinic;Clinical;clinical translation;Clonal Expansion;cohort;computational pipelines;CRISPR library;Custom;Data;Databases;Dimensions;DNA Library;DNA Sequence Alteration;driver mutation;Drug Screening;Evolution;exome sequencing;experience;Fistula;Freezing;Fresh Tissue;Future;Gene Pool;Genes;genetic testing;Hemorrhage;high risk;human tissue;Immune;improved;In Vitro;in vitro testing;Institution;Laboratories;large-scale database;Libraries;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Methods;microbiome;Modeling;Mutate;Mutation;new therapeutic target;novel;Organoids;Pathway interactions;patient population;Patients;Pharmaceutical Preparations;Pharmacotherapy;Pilot Projects;Population;Precision therapeutics;predictive marker;Prognostic Marker;Publishing;Qualifying;radiation resistance;radiation response;Radiation-Sensitizing Agents;Radiosensitization;Recording of previous events;Relapse;research clinical testing;Resistance;response;Risk;risk variant;Sampling;screening;single-cell RNA sequencing;standard of care;Swab;targeted agent;targeted treatment;Techniques;Testing;therapeutically effective;Tissue Banks;Tissues;Translating;Treatment outcome;tumor;tumorigenesis;Woman;Women's mortality

PROJECT_TITLE: Identifying Novel Radiation Sensitizers in Cervical Cancer


NIH_SPENDING_CATS: Digestive Diseases;Microbiome

PROJECT_TERMS: advanced analytics;Advocate;Animal Model;Animals;Applications Grants;Area;Award;Basic Science;Biology;Biometry;Budgets;career development;Clinical;Clinical Research;clinical translation;Communication;Communities;cost effective;Digestive System Disorders;Disease;Ensure;Epidemiology;Event;Expenditure;Feasibility Studies;Fostering;gastrointestinal;Gnotobiotic;Goals;Grant;Homeostasis;Human Resources;Individual;injury and repair;Institution;instrument;Interdisciplinary Study;Laboratories;Leadership;member;Mentors;microbiome;Mission;Monitor;multidisciplinary;National Institute of Diabetes and Digestive and Kidney Diseases;Participant;Performance;Personnel Management;Preparation;programs;Property;Publications;Records;Regenerative Medicine;Regulation;repaired;Reporting;Research;Research Personnel;Research Project Grants;Research Support;Resources;Science;Surveys;Time;Training;Translational Research;United States National Institutes of Health;University adminstration

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Clinical Research;Foodborne Illness;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Microbiome;Nutrition;Pediatric;Prevention;Rural Health

ORG_CITY: HANOVER

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: Project Narrative Exposure to arsenic early in life results in the loss of key gut microbiota that tune local and systemic immunity. Here, we propose to use a combination of human-focused studies, molecular studies with lab cell models, and animal work to understand how the arsenic-mediated loss of Bacteroides impacts immunity and health outcomes, and how arsenic-mediated effects can be mitigated.

PI_NAMEs: O'TOOLE, GEORGE A. (contact)

PROGRAM_OFFICER_NAME: DZIERLENGA, ANIKA LIN

PROJECT_TERMS: 12 year old;3 year old;Address;Affect;Animals;Antibiotics;Arsenic;Back;Bacteroides;bioinformatics tool;Birth;Cell Culture Techniques;Cell model;Child;children with cystic fibrosis;Clinical;Clinical Research;Cohort Studies;Development;dietary;drinking water;dysbiosis;early childhood;Enrollment;Environmental Epidemiology;Environmental Pollutants;epidemiologic data;Epidemiology;epigenome;epigenomics;Exposure to;Feces;Food;Future;Goals;gut microbiome;gut microbiota;Health;Human;IL8 gene;Immune;Immune system;Immunity;In Vitro;Individual;Infant;Inflammation;insight;Intervention;intestinal epithelium;Intestines;Laboratories;Life;Link;Lung;lung health;Mediating;metabolome;Metal exposure;Metals;Methods;Microbe;microbiome;microbiome alteration;microbiome composition;microbiome research;microbiota composition;Molecular;Mothers;mouse model;National Institute of Environmental Health Sciences;New Hampshire;novel;Organoids;Outcome;Pattern;Pneumonia;Policies;Prevention;Probiotics;Propionates;pulmonary function;Regulation;Resources;Respiratory Disease;respiratory health;Risk;risk mitigation;Rural Community;Rural Population;sex;Testing;Time;Toxic Environmental Substances;toxic metal;toxicant;Training;Upper Respiratory Infections;Volatile Fatty Acids;Water;Wheezing;Work

PROJECT_TITLE: Arsenic, the Microbiome & Health Outcomes: Mechanisms to Methods of Intervention

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-A(90)S]


NIH_SPENDING_CATS: Digestive Diseases

PI_NAMEs: KEKU, TEMITOPE O. (contact)

PROJECT_TERMS: biological research;Biology;career;career development;Climate;Collaborations;Communication;Communities;community building;Digestive System Disorders;Disease;Education;Educational workshop;Ensure;Epidemiology;Event;Fostering;gastrointestinal;Individual;Interdisciplinary Study;interest;lectures;member;Mentorship;microbiome;Mission;Play;Postdoctoral Fellow;programs;Research;Research Personnel;Role;Scholars Program;Series;visiting scholar

PROJECT_TITLE: Enrichment Program


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: Project Narrative b-lactamases are enzymes that hydrolyze b-lactam antibiotics to provide bacterial drug resistance and the emergence of b-lactamases that are capable of hydrolyzing virtually all b-lactam antibiotics is a significant threat to the efficacy of antibiotic therapy. The proposed experiments utilize enzyme kinetics, X-ray crystallography and molecular dynamics simulations is to provide a quantitative understanding of how b- lactam antibiotics traverse the catalytic pathway of KPC b-lactamases, yielding insights necessary for the rational design of molecules that act are poorly hydrolyzed as well as inhibitors of these enzymes.

PI_NAMEs: PALZKILL, TIMOTHY  (contact)

PROGRAM_OFFICER_NAME: HUNTLEY, CLAYTON C

PROJECT_TERMS: Active Sites;Acylation;Address;Affect;Affinity;Anti-Bacterial Agents;antibiotic design;Antibiotic Resistance;Antibiotic Therapy;Antibiotics;Bacterial Antibiotic Resistance;Bacterial Drug Resistance;bacterial resistance;base;beta-Lactamase;beta-Lactams;Binding;carbapenem resistance;carbapenemase;Carbapenems;Catalysis;Ceftazidime;Cephalosporins;Chemicals;Clinical;Complex;deacylation;Death Rate;design;Drug resistance;Drug usage;Enzyme Inhibitor Drugs;Enzyme Kinetics;Enzymes;experimental study;Floor;Funding;Future;Goals;Hydrolysis;Individual;Infection;infection rate;inhibitor;insight;interdisciplinary approach;Kinetics;Klebsiella pneumoniae;Knowledge;Lactamase;Lactams;Link;Modification;Molecular;molecular dynamics;Monobactams;Mutation;Natural Resistance;Organism;pathogen;Pathway interactions;Penicillins;Pharmaceutical Preparations;Predisposition;Property;rational design;Reaction;Resistance;resistance mechanism;Roentgen Rays;Specificity;Structure;Structure-Activity Relationship;Substrate Specificity;Testing;tool;Variant;virtual;X-Ray Crystallography

PROJECT_TITLE: BETA LACTAMASE MUTATIONS IN ANTIBIOTIC RESISTANCE

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AIDC-V(02)]


PI_NAMEs: SARTOR, RYAN B (contact)

PROJECT_TERMS: Address;Animal Experiments;Animals;Anorexia;Applications Grants;autism spectrum disorder;Bacteria;bacterial community;Behavioral;Biology;Cells;Chronic Disease;college;Colon;Communities;Complex;Consult;cost;Custom;Data;deep sequencing;Derivation procedure;design;Diabetes Mellitus;Diet;dietary;Disease;disease phenotype;dysbiosis;Embryo Transfer;Environmental Risk Factor;Etiology;Experimental Designs;experimental study;fecal microbiota;fecal transplantation;Film;flexibility;fungus;gastrointestinal;Gene Deletion;Genes;Genetic Engineering;Genetic Predisposition to Disease;Genetic Risk;Genetically Engineered Mouse;Germ-Free;Gnotobiotic;gut microbiota;Homeostasis;host-microbe interactions;Human;human disease;humanized mouse;improved;Inbred Mouse;Individual;Infection;Inflammatory;Injury;injury and repair;innovation;International;intestinal homeostasis;Intestines;Investigation;Knock-out;Libraries;Link;Location;Malignant neoplasm of pancreas;member;Mental Depression;Metabolic;Metabolic syndrome;metabolomics;Microbe;microbial;microbiota;microorganism;Modeling;Monitor;Mouse Strains;multidisciplinary;Mus;mutant;Mutant Strains Mice;Mutate;Nature;neoplastic;nonalcoholic steatohepatitis;North Carolina;Obesity;Organ;Parasites;Pathogenesis;Pathogenicity;Physiological;Physiological Processes;Physiology;Predisposition;Quality Control;repaired;Reporter;Reproducibility of Results;Research;Research Design;Research Personnel;Resources;response;Retroviridae;Series;Services;Sterility;Techniques;Technology;Tissues;Training;Transgenic Organisms;Universities;Veterinary Medicine;Viral;Virus;Wild Type Mouse

PROJECT_TITLE: Gnotobiotic Core


NIH_SPENDING_CATS: Digestive Diseases;Networking and Information Technology R&D (NITRD)

PI_NAMEs: DELLON, EVAN SAMUEL (contact)

PROJECT_TERMS: administrative database;Admission activity;Biological;Biology;Biometry;Cessation of life;Clinical;Clinical Data;Clinical Research;Colitis;Collaborations;Collection;computer science;Computers;Conceptions;Consultations;Contracts;cost;cost effective;Crohn's disease;Data;Data Analyses;Data Collection;Data Coordinating Center;data management;data modeling;Data Security;Databases;design;Development;Digestive System Disorders;Disease;Effectiveness;Engineering;epidemiologic data;Epidemiologic Methods;Epidemiologist;Epidemiology;Evolution;experience;Faculty;Fee-for-Service Plans;Foundations;Funding;Gastroenterology;gastrointestinal;healthcare burden;Informatics;Inpatients;Institutional Review Boards;Interdisciplinary Study;interest;Link;Logistics;Maintenance;Mediation;Medicare;member;Mission;model development;Monitor;Outpatients;Phase;Physicians;Process;Productivity;Publications;Publishing;Quality Control;Reporting;Research;Research Design;Research Personnel;Research Support;response;sample collection;Sample Size;Scientist;Secure;Services;sound;Source;Specialist;Specimen Handling;Statistical Data Interpretation;statistical service;Statistical Study;statistics;Support Contracts;System;Techniques;Time;Tissue Procurements;Training;Training and Education;Translational Research;translational scientist;Trust;United States;Validation;Visit;web app

PROJECT_TITLE: Biostatistics and Clinical Research Core


NIH_SPENDING_CATS: Charcot-Marie-Tooth Disease;Genetics;Neurodegenerative;Neurosciences;Peripheral Neuropathy;Rare Diseases

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Narrative The ability of Schwann cells to transition between different cell fates is essential for the formation and repair of myelin sheaths surrounding peripheral nerves. This proposal will investigate the requirements of endosomal signaling for the maturation of Schwann cells. The completion of these aims will fill an important gap in our understanding of the endosomal regulation of cell signaling during development and identify potential therapeutic targets to enhance myelin production.

PI_NAMEs: WILSON, SCOTT MICHAEL (contact)

PROGRAM_OFFICER_NAME: NUCKOLLS, GLEN H

PROJECT_TERMS: Affect;Alleles;Animal Model;Axon;Binding;Biochemical;Biological;Biological Models;Biology;Cell Culture Techniques;Cell Differentiation process;Cell Maturation;Cell Physiology;Cell Proliferation;Cell Surface Receptors;cell type;Cells;Central Nervous System;Charcot-Marie-Tooth Disease;Communication;Complex;Critical Pathways;Cyclic AMP;Data;Defect;Demyelinating Diseases;Demyelinations;Development;dimer;Disease;dysmyelination;EGFR gene;Endosomes;ERBB2 gene;experimental study;extracellular;Foundations;Functional disorder;functional restoration;Gene Expression;gene induction;Genes;genetic analysis;Goals;hepatocyte growth factor-regulated tyrosine kinase substrate;HGS gene;Impairment;improved;Inherited;insight;Instruction;Laboratories;Leukoencephalopathy;Link;migration;Motor;mouse model;Mus;Mutant Strains Mice;Mutation;Myelin;Myelin Sheath;myelination;Nervous System Disorder;Nervous System Physiology;Neuregulin 1;Neuropathy;novel;Pain;Paralysed;Pathway interactions;Patients;Peripheral;Peripheral Nerves;Peripheral Nervous System;Peripheral Nervous System Diseases;Persons;Positioning Attribute;Process;Production;Proliferating;protein complex;Proteins;Radial;receptor;receptor function;receptor internalization;Receptor Protein-Tyrosine Kinases;Receptor Signaling;Regulation;Regulatory Pathway;repaired;RNA Sequence Analysis;Rodent Model;Role;Route;Schwann Cells;sciatic nerve;Sensory;Signal Pathway;Signal Transduction;Sorting;Testing;therapeutic target;therapy development;trafficking;transcriptome sequencing;treatment strategy;United States

PROJECT_TITLE: The Role of ESCRTs in Regulating Nervous System Function

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Digestive Diseases;Genetics;Human Genome;Inflammatory Bowel Disease;Microbiome;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

PI_NAMEs: MAGNESS, SCOTT T (contact)

PROJECT_TERMS: Adherent Culture;advanced analytics;Affect;Ascending colon;Basic Science;biobank;Biological Assay;Biological Markers;Biology;Biopsy;Businesses;Cells;Cellular Assay;chemokine;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Colon;Consultations;cost;Cryopreservation;Culture Media;Custom;cytokine;Data;Descending colon;Detection;Diabetes Mellitus;Diagnostic;Digestive System Disorders;Disease;Disparate;DNA sequencing;Doctor of Philosophy;Donor person;Duodenum;Enzyme-Linked Immunosorbent Assay;Epithelium;epithelium regeneration;Excision;Feces;Fluorescence-Activated Cell Sorting;gastrointestinal;Gastrointestinal tract structure;Gene Expression Profiling;Genes;Genotype;Health;high throughput screening;Human;human model;Human Resources;ileum;Immunoassay;In Vitro;in vitro Model;Inflammatory;Inflammatory Bowel Diseases;Inflammatory Response;Injury;innovation;Interdisciplinary Study;Intestines;jejunum;Laboratories;Liver diseases;Malignant Neoplasms;member;Methods;microbial community;microbiome;MicroRNAs;Mission;model organism;Modeling;Modification;mouse model;Mucous Membrane;multiplex assay;Mus;Natural regeneration;Nature;new technology;Organ Donor;Organoids;Output;Patients;Phenotype;Physiological;Population;Process;protein expression;Proteins;Resolution;RNA;Sampling;self-renewal;Services;single cell genomics;single cell sequencing;single-cell RNA sequencing;SNP genotyping;Source;stem cell expansion;stem cells;stool sample;Technology;Testing;Tissue Model;Tissues;Training;transcriptomics;Transverse colon;Western Blotting

PROJECT_TITLE: Advanced Analytics Core


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric

ORG_CITY: TUSCALOOSA

ORG_NAME: UNIVERSITY OF ALABAMA IN TUSCALOOSA

PHR: PROJECT NARRATIVE This study will inform our understanding of how to support emerging adults with autism spectrum disorder (ASD). We will use a theoretically informed and research-based transition support program developed for people with ASD and test how effective it is when delivered by community agencies. Results will provide information on the effectiveness of the program as well as on mechanisms of change and contextual factors that promote or impede implementation.

PI_NAMEs: WHITE, SUSAN WILLIAMS (contact)

PROGRAM_OFFICER_NAME: BURSTEIN, MARCY ELLEN

PROJECT_TERMS: active control;Address;Adolescent and Young Adult;adolescent with autism spectrum disorder;Adult;adult with autism spectrum disorder;Advocate;Aftercare;Age;Attitude;autism spectrum disorder;Behavior;Characteristics;Client;Clinic;Clinical;Clinical effectiveness;clinical practice;college;Communities;community clinic;community engagement;community partners;Consolidated Framework for Implementation Research;contextual factors;Cultural Sensitivity;Data;design;Economic Burden;Education;Educational Curriculum;Effectiveness;Effectiveness of Interventions;effectiveness testing;effectiveness trial;emerging adult;Employment;Enrollment;evidence base;Face;Family;Feedback;follow-up;functional independence;functional outcomes;Future;Goals;high school;Hybrids;Impairment;implementation barriers;implementation design;implementation facilitators;implementation/effectiveness;impression;improved;improved outcome;Independent Living;Individual;individuals with autism spectrum disorder;Informal Social Control;informant;Interpersonal Relations;Intervention;Interview;Life;Light;Mediating;Mediation;Methods;Modeling;Occupations;Outcome;Outcome Assessment;Participant;peer;Persons;Population;post implementation;post intervention;Practical trial;Preparation;primary outcome;Program Effectiveness;programs;Provider;Public Health;Qualitative Methods;Quality of life;Randomized;Randomized, Controlled Trials;Readiness;Regulation;Reporting;Research;Sampling;Secondary Schools;Self Determination;Self Perception;self reliance;services as usual;Site;skill acquisition;skills;Social Interaction;Speed;stakeholder perspectives;Structure;Students;success;teleconsultation;Testing;Thinking;Training;transition to adulthood;Translations;Unemployment;Vocation;Vocational rehabilitation;young adult;young adult with autism spectrum disorder

PROJECT_TITLE: Stepped Transition in Education Program for Emerging Adults with Autism: Pilot Effectiveness Trial


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Diabetes;Digestive Diseases;Eye Disease and Disorders of Vision;Neurosciences;Nutrition

ORG_DEPT: OPHTHALMOLOGY

PHR: PROJECT NARRATIVE In this application, we will examine how the retina and the gut communicate and how this communication is altered by the presence of type 2 diabetes. We will study how the loss of a critical protein, angiotensin converting enzyme 2 (ACE2), in diabetes disturbs glucose absorption and the release of gut hormones that regulate blood glucose levels. Finally, we test how loss of ACE2 influences gut barrier function to impact systemic inflammation and progression of diabetic retinopathy.

PI_NAMEs: BOULTON, MICHAEL EDWIN;GRANT, MARIA BARTOLOMEO (contact)

PROGRAM_OFFICER_NAME: GORDIYENKO, NATALIYA

PROJECT_TERMS: absorption;ACE2;Angiotensin II;Angiotensins;arm;Binding;Blood;Blood capillaries;Blood Glucose;blood glucose regulation;Blood-Retinal Barrier;Bone Marrow;Bypass;Cells;Circulation;Clinical;Clinical Trials;Communication;Continuous Glucose Monitor;Data;db/db mouse;Defect;Deterioration;Development;Diabetes Mellitus;diabetic;Diabetic mouse;Diabetic Retinopathy;Dimerization;Dipeptides;Endocrine;Endothelial Cells;Enterocytes;Epithelial Cells;Equilibrium;Extravasation;Eye;Functional disorder;G-Protein-Coupled Receptors;gastrointestinal epithelium;Genetic;Glucagon;Glucose;glucose transport;Goals;gut dysbiosis;gut microbiome;Health;Homeostasis;Hormones;Human;Hyperglycemia;Immune;immune activation;Insulin;interest;Interruption;intestinal epithelium;Intestinal permeability;Intestines;Leaky Gut;Leukostasis;Ligands;Literature;loss of function;Mediating;Metabolic;microbial;Microvascular Dysfunction;Mus;Myeloid Cells;Non-Insulin-Dependent Diabetes Mellitus;novel;Nutraceutical;overexpression;Pancreas;Pathogenesis;Pathology;Pattern recognition receptor;Peptides;Permeability;Phenotype;Physiological;prevent;Probiotics;Production;Proteins;receptor;Receptor Activation;Renin-Angiotensin System;restoration;Retina;Role;Serum;systemic inflammatory response;Testing;Tissues;Toll-like receptors;Tryptophan;uptake;Work

PROJECT_TITLE: ACE2 on gut barrier dysfunction and BRB disruption


PI_NAMEs: BLIKSLAGER, ANTHONY  (contact)

PROJECT_TERMS: 3-Dimensional;Address;Anesthesia procedures;animal care;Animal Experimentation;Animal Hospitals;Animal Model;Animals;base;Basic Science;Biology;Board Certification;Budgets;Cell Culture System;Cell Culture Techniques;Cells;Collaborations;college;Complex;Consultations;cost effective;design;Development;Digestive System Disorders;Discipline of Nuclear Medicine;Disease;disease model;Endoscopy;Eosinophilic Esophagitis;Esophageal Diseases;Esophagus;expectation;experimental study;facility renovation;Family suidae;Fostering;Funding;Gastroesophageal reflux disease;gastrointestinal;Gastrointestinal tract structure;Gland;Gnotobiotic;Goals;Grant;Health;Housing;Human;Image;improved;In Vitro;Interdisciplinary Study;interest;Internal Medicine;Ischemia;Ischemic Bowel Disease;Laboratory Animal Medicine;Logistics;Magnetic Resonance Imaging;Medical;medical schools;Medicine;member;microbiome;Mission;Modeling;Mus;novel;Operative Surgical Procedures;Output;Persons;Physiological;Postoperative Period;Procedures;Radiofrequency Interstitial Ablation;Research;Research Design;Research Personnel;Resources;response;Running;Sedation procedure;Source;Specialist;stem cells;Submucosa;System;Techniques;Technology;Time;Translating;translational model;United States National Institutes of Health;Universities;Veterinarians;Veterinary Medicine;Veterinary Schools;Work

PROJECT_TITLE: Large Animal Core