ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Prevention;Social Determinants of Health

ORG_DEPT: NEUROLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: NARRATIVE- OVERALL The Alzheimer's Disease Research Center (ADRC) at New York University Langone Health has facilitated pioneering research to define transitions from normal aging to the subjective cognitive decline (SCD), mild cognitive impairment (MCI), and early dementia stages of AD; as well as AD biomarker development. We now propose to continue this long-standing successful research direction with a focus on understanding disease heterogeneity and delineating biomarkers and their role in these transitions, with the long-term goal of helping to develop novel interventions that will delay or prevent cognitive decline, to help achieve the NAPA goal of a cure by 2025.

PI_NAMEs: WISNIEWSKI, THOMAS M (contact)

PROGRAM_OFFICER_NAME: ELLIOTT, CERISE

PROJECT_TERMS: Acceleration;aged;aging brain;Alzheimer's Disease;Amyloid;Area;Autopsy;Behavioral;Biological Assay;Biological Markers;biomarker development;biomarker identification;Cerebrospinal Fluid;Clinical;Clinical Data;clinical training;Cognitive;cognitive function;cognitive testing;Collaborations;Communities;community setting;Counseling;Cyclotrons;Data Linkages;data management;Data Set;Dementia;Development;Diagnosis;Diagnostic Services;disease heterogeneity;Early Diagnosis;Education;education research;epidemiology study;Fostering;Funding;Goals;Health;Heterogeneity;Impaired cognition;improved;in vivo;induced pluripotent stem cell;Infrastructure;innovation;Intervention;Investigation;Laboratories;Magnetic Resonance Imaging;Measures;Mental Depression;Methodology;mild cognitive impairment;Mission;neuroimaging;neuropathology;Neuropsychology;New York;next generation;normal aging;novel;novel marker;novel therapeutic intervention;outreach;Participant;Pathology;Patients;Performance;Phenotype;Plasma;Population;Positron-Emission Tomography;posters;prevent;programs;Proteomics;Psychological Impact;psychosocial;Radiochemistry;recruit;Research;Role;Scanning;Scientist;Secure;Serum;social factors;sociodemographic variables;Statistical Data Interpretation;Stress;tau Proteins;Techniques;Therapeutic Intervention;therapeutically effective;Time;Training;Training and Education;Translational Research;Universities;Update;Work

PROJECT_TITLE: Alzheimer's Disease Research Center


ADMINISTERING_IC: GM

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Autoimmune Disease;Building Research Capacity at Institutions with Limited NIH Funding;Cardiovascular;Contraception/Reproduction;Hypertension;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Women's Health Research

ORG_CITY: JACKSON

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF MISSISSIPPI MED CTR

ORG_STATE: MS

PI_NAMEs: AMARAL, LORENA M (contact)

PROGRAM_OFFICER_NAME: GARTRELL, KYUNGSOOK

PROJECT_TERMS: Activated Lymphocyte;Affect;Angiotensins;Arteries;Attenuated;Autoantibodies;B-Lymphocytes;blocking factor;blood pressure reduction;Caproates;Cells;Chronic;Clinical Data;cytokine;Dahl Hypertensive Rats;Data;Development;endothelial dysfunction;Endothelin;Endothelin-1;Endothelium;fetal;Fetal Growth Retardation;Fetus;Functional disorder;Hydroxyprogesterone;Hypertension;improved;In Vitro;in vivo;indexing;Inflammation;Inflammatory;Interleukin-4;Ischemia;Lymphocyte;Maintenance;Maternal Mortality;Mississippi;Modeling;Mothers;Mus;Natural Killer Cells;Nitric Oxide;offspring;Patients;Perfusion;Perinatal;perinatal morbidity;Phase;Placenta;Pre-Eclampsia;Pregnancy;pregnant;pressure;prevent;Production;Progesterone;Progesterone Receptors;Proteins;Publishing;Rattus;receptor;Relaxation;Reporting;Research;Resistance;response;Risk;Role;Supplementation;Testing;Th1 Cells;Uterus;Vascular Endothelial Growth Factor Receptor-1

PROJECT_TITLE: Project 003 - Lorena Amaral


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: ANN ARBOR

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Narrative was not required in the original submission.

PI_NAMEs: TELESNITSKY, ALICE  (contact)

PROGRAM_OFFICER_NAME: MCDONALD, DAVID JOSEPH

PROJECT_TERMS: Address;Anti-viral Agents;Area;base;Biological;Biological Process;Biology;biophysical techniques;Cells;clinically relevant;comparative;Complex;design;Development;Disease;Elements;Genetic Transcription;Goals;HIV;HIV Infections;HIV-1;Host Defense;Immune response;Immunologist;Integration Host Factors;Maintenance;member;multidisciplinary;novel;particle;Prevention;protein function;Proteins;Proviruses;reactivation from latency;Resolution;RNA;RNA Splicing;RNA-targeting therapy;Role;Structural Biologist;structural biology;Structure;Techniques;Technology;Therapeutic Uses;trafficking;Translations;Viral;Virus Replication

PROJECT_TITLE: Center for Structural Biology of HIV RNA


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Health Services;Machine Learning and Artificial Intelligence;Major Depressive Disorder;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Serious Mental Illness;Women's Health Research

ORG_CITY: PITTSBURGH

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: CARNEGIE-MELLON UNIVERSITY

ORG_STATE: PA

PHR: RELEVANCE (See instructions}: Depression is one of the most common complications of pregnancy and there are interventions that can help treat or even prevent depression symptoms among pregnant people. The earlier individuals start such preventive care, the sooner it can work, but there are often limited numbers of mental health care providers available, and it is not yet known which treatments work best for which patients. This research will help tailor treatment approaches to proactively prevent depression before it starts.

PI_NAMEs: KRISHNAMURTI, TAMAR ;WILDER, BRYAN  (contact)

PROGRAM_OFFICER_NAME: LUSHIN, VICTOR

PROJECT_TERMS: Acceleration;Algorithms;Area;Behavioral;Cause of Death;Characteristics;Clinical;Collection;Consultations;Data;Decision Making;decision research;depressive symptoms;E-learning;experience;experimental study;Feedback;Foundations;Goals;Health;Health Personnel;Health system;improved;Individual;individualized medicine;innovation;Instruction;Intervention;Interview;Lived experience;Machine Learning;machine learning algorithm;machine learning method;Maternal Health;Maternal-fetal medicine;Measures;Medical;Mental Depression;Mental Health Services;method development;Methodology;Methods;Mothers;Output;Patient Care;Patients;Perinatal;perinatal mental health;perinatal period;peripartum depression;personalized intervention;personalized learning;Persons;Physician Executives;Physicians;Pilot Projects;Policies;preference;Pregnancy Complications;pregnant;prevent;Preventive care;preventive intervention;Provider;Psychiatrist;Psychiatry;Public Health;Randomized;Research;Research Design;Research Methodology;Resources;routine screening;Running;Services;Social Sciences;Structure;Suicide;System;Techniques;Technology;theories;therapy design;trustworthiness;Women's Health;Work

PROJECT_TITLE: SCH: Machine learning for personalized preventative intervention in perinatal depression

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IVBH-N (50)]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Data Science;Dissemination and Implementation Research;Health Services;Hematology;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Sepsis

ORG_CITY: SAN DIEGO

ORG_NAME: CLAIRYON, INC.

ORG_STATE: CA

PHR: Narrative The proposed project will make use of artificial intelligence (AI) to collect and analyze data from hospitalized patients with sepsis. We plan to conduct a clinical study to quantify the benefit of an AI assisted care protocol to reduce organ failure in patients with sepsis. We intend to seek regulatory approval for our AI system to maintain quality assurance and ensure patient safety. We have a very strong team of doctors and researchers who work closely together, covering all aspects of the proposed project, which we hope will help us improve the care of hospitalized patients with sepsis.

PI_NAMEs: JOSEF, CHRISTOPHER  (contact)

PROGRAM_OFFICER_NAME: RITCHIE, ALEC

PROJECT_TERMS: Accident and Emergency department;Address;Adherence;advanced analytics;Adverse event;Affect;American;Antibiotics;antimicrobial;Artificial Intelligence;Awareness;Behavior;California;care systems;Caregivers;Caring;Cessation of life;Classification;Clinical;clinical application;Clinical Data;clinical decision support;Clinical Decision Support Systems;Clinical Research;Collaborations;commercialization;Computer software;cost;Critical Care;dashboard;Data;data access;data integration;design;Development;Diagnosis;diagnostic accuracy;Effectiveness;Electronic Health Record;Ensure;evidence base;Expert Systems;Fast Healthcare Interoperability Resources;FDA approved;Feedback;Frequencies;General Ward;Geography;Goals;Health;Health Insurance Portability and Accountability Act;Healthcare Systems;hemodynamics;high dimensionality;Hospitalization;Hospitals;Hour;improved;Infection;Inflammation;innovation;Intensive Care Units;Intervention;Intuition;Laboratories;Learning;Length of Stay;Licensing;Life;Liquid substance;Machine Learning;Measures;Modeling;Morbidity - disease rate;mortality;Names;new technology;next generation;nonbinary;novel;Nursing Assessment;Organ failure;Patient Care;patient population;patient response;patient safety;Patient-Focused Outcomes;Patients;Pattern;Pattern Recognition;Performance;personalized care;Pharmaceutical Preparations;Phase;predictive modeling;predictive tools;prospective;Prospective Studies;Protocols documentation;prototype;quality assurance;Research;Research Personnel;response;Resuscitation;Risk;Safety;Sepsis;Shoulder;software as a medical device;Specificity;Surveys;Syndrome;System;Technology;Testing;Time;tool;treatment response;Uncertainty;United States Centers for Medicare and Medicaid Services;Universities;usability;Validation;web services;Weight;Work

PROJECT_TITLE: AIVIS: Next Generation Vigilant Information Seeking Artificial Intelligence-based Clinical Decision Support for Sepsis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HSS-J(10)B]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cardiovascular;Clinical Research;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Human Genome;Women's Health Research

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: Project Narrative: Fibromuscular dysplasia (FMD) is an arterial disease that can cause stenosis (inward growth), aneurysm (outward growth), dissection (tearing), or tortuosity (abnormal bending) of blood vessels, leading to manifestations such as high blood pressure, stroke, heart attacks, and death. These dysplasia-associated arterial diseases are estimated to occur in 1-4% of the U.S. population and most often afflicts women. This study will use genetic and laboratory approaches to discover and characterize the involved genes and understand their functions in causing pathologic changes in the arterial wall, leading to the cardiovascular manifestations; the biologic insights from this study will be important for developing novel diagnostic and therapeutic strategies.

PI_NAMEs: GANESH, SANTHI K (contact)

PROGRAM_OFFICER_NAME: CATANIA, SELEN MURATOGLU

PROJECT_TERMS: Alleles;Aneurysm;Arterial Disorder;Arteries;Award;Beds;Biological;Biological Models;Biomedical Engineering;Blood Vessels;Cardiovascular Diseases;Cardiovascular Manifestation;Cell model;Cessation of life;Complex;Coronary artery;Disease;Disproportionately impacts women;Dissection;Doctor of Philosophy;Dysplasia;Engineering;Extracellular Matrix;Fibromuscular Dysplasia;Genes;Genetic;genetic architecture;Genetic Predisposition to Disease;genetic variant;Genomics;Goals;Growth;Heritability;Hypertension;insight;Laboratories;Modeling;Morbidity - disease rate;mortality risk;Myocardial Infarction;novel;novel diagnostics;novel therapeutic intervention;Outcome;Pathologic;Population;Postdoctoral Fellow;Predisposition;Resolution;Sex Differences;Smooth Muscle;Stenosis;Stroke;Susceptibility Gene;Testing;Tissue Model;Tissues;Training Support;Variant;variant of unknown significance;Vascular Smooth Muscle;Woman

PROJECT_TITLE: Genomic and Functional Studies of Dysplasia-Associated Arterial Diseases


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: BALTIMORE

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: NARRATIVE Anticancer drug resistance often results from cancer cells bypassing the targeted pathway by adopting alternative mechanisms to maintain their growth. We have identified hnRNP A18 as a key regulator of several cellular pathways controlling cancer growth and immune protection. Using structural biology, Computer Aided Drug Design, medicinal chemistry and cellular biology we are developing small molecules that can selectively inhibit hnRNP A18 to prevent cancer cells growth and immune evasion.

PI_NAMEs: CARRIER, FRANCE  (contact);FLETCHER, STEVEN ;WEBER, DAVID JOSEPH

PROGRAM_OFFICER_NAME: AGYIN, JOSEPH KOFI

PROJECT_TERMS: 3' Untranslated Regions;5' Untranslated Regions;Adopted;Affinity;analog;angiogenesis;Antibodies;Antineoplastic Agents;Apoptosis;Binding;Biological;Biological Assay;Bypass;cancer cell;Cancer Cell Growth;Cancer Control;cancer drug resistance;cancer therapy;cancer type;Cell Physiology;Cell Proliferation;Cells;Cellular biology;Chemicals;chemotherapy;Clinic;Clinical;Computer Assisted;CTLA4 gene;Data;design;Development;DNA Repair;Dose;Down-Regulation;Drug Combinations;Drug Design;drug resistance development;Effectiveness;efficacy testing;Eukaryotic Initiation Factor-4G;Exhibits;Feedback;flexibility;FRAP1 gene;Generations;Goals;Growth;Heterogeneous-Nuclear Ribonucleoproteins;Homeostasis;Human;Immune;immune checkpoint;Immune checkpoint inhibitor;Immune Evasion;Immune response;Immune Targeting;Immunologist;improved;In Vitro;in vivo;inhibitor;innovation;Lead;Malignant Neoplasms;Mantle Cell Lymphoma;Medicine;Messenger RNA;Metabolism;Methods;Modeling;Modification;multidisciplinary;Mus;Neoplasm Metastasis;Normal Cell;Normal tissue morphology;novel;Oncologist;overexpression;Pathway interactions;Patients;Pharmaceutical Chemistry;Pharmaceutical Preparations;PIK3CG gene;Plasma;precision medicine;prevent;Proliferating;Property;Protein Biosynthesis;Protein Inhibition;Proteins;rational design;Regulatory Pathway;Renal Cell Carcinoma;Reporter;Resistance;response;Reverse Transcriptase Inhibitors;Ribonucleoproteins;RNA;RNA Binding;RNA Polymerase Inhibitor;RNA Recognition Motif;RNA-Binding Proteins;RNA-Protein Interaction;Role;scaffold;Schedule;small molecule;small molecule inhibitor;Solid Neoplasm;Solubility;Specificity;Stress;Structural Biologist;structural biology;targeted cancer therapy;Therapeutic;Therapeutic Agents;Therapeutic Index;three dimensional structure;Toxic effect;Transcript;Translation Initiation;Translational Repression;Translations;Tuberous Sclerosis;tumor;tumor growth;tumor progression;Viral;virtual;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Investigating the hnRNPA18-HIF-1a axis in solid tumors


NIH_SPENDING_CATS: Biotechnology;Cancer;Dental, Oral, and Craniofacial Disease;Immunotherapy;Orphan Drug;Rare Diseases

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Project Narrative When developing new cancer treatments, many scientists use animal models in which human tumors are implanted into research animals (i.e. patient-derived xenografts or PDXs). However, we lack understanding of how we bias our results based on the methods we use to make new PDXs (e.g. implanting tumor pieces under the skin of immunocompromised mice as opposed to implanting into the site of origin). To improve the efficiency of pre-clinical research, this proposal will provide a clear answer to this question in head and neck cancer by methodically studying how tumor response to chemotherapy changes over time and the impact of a immune system on tumor evolution.

PI_NAMEs: KIMPLE, RANDALL J. (contact)

PROGRAM_OFFICER_NAME: WATSON, JOANNA M

PROJECT_TERMS: Address;Affect;Animal Experimentation;Animal Model;anti-cancer treatment;Biological;Biological Models;Biology;Cancer Model;cancer therapy;career;Cetuximab;chemotherapy;Cisplatin;Clinical;Clinical Trials;Communication;cost;Data;DNA Sequence Alteration;DNA sequencing;Educational process of instructing;Evolution;expectation;experience;Generations;Genetic;Genetic Variation;Goals;Head and Neck Cancer;head and neck cancer patient;Histologic;HPV positive;HPV-negative head and neck cancer;Human;Human Biology;human disease;human model;immune cell infiltrate;Immune system;Immunocompetent;Immunocompromised Host;Immunotherapy;Implant;implantation;improved;improved outcome;In Situ;In Vitro;innovation;Longevity;Malignant Neoplasms;Mentors;Methodology;Methods;Minority Graduate Student;Modeling;Molecular;mouse model;Mus;Nose;novel;novel therapeutics;Operative Surgical Procedures;Oral;Organoids;Outcome;Pathway interactions;Patient Care;patient derived xenograft model;patient response;Patient-Focused Outcomes;Patients;Pharmacology;Pharyngeal structure;pre-clinical;pre-clinical research;prevent;Primary Neoplasm;programs;Research;Resistance;response;Role;Science;Scientist;Serial Passage;Signal Pathway;single-cell RNA sequencing;Site;Skin;Specimen;Squamous cell carcinoma;Squamous Epithelium;standard care;subcutaneous;targeted treatment;Testing;Therapeutic Studies;therapy resistant;Time;Training;Translating;translational model;Treatment outcome;treatment response;tumor;Tumor Biology;tumor microenvironment;tumor-immune system interactions;Use Effectiveness

PROJECT_TITLE: Improving the translational value of head and neck cancer patient-in-mouse models

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(55)-R]


NIH_SPENDING_CATS: Bioengineering;Cancer;Clinical Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: PISCATAWAY

ORG_NAME: RUTGERS, THE STATE UNIV OF N.J.

ORG_STATE: NJ

PI_NAMEs: WANG, HAO  (contact)

PROGRAM_OFFICER_NAME: RIZWAN, ASIF M

PROJECT_TERMS: accurate diagnosis;Algorithms;Area;artificial intelligence model;Biological;cancer diagnosis;cancer subtypes;Classification;Clinical;Data Set;deep learning;deep learning model;Dependence;Dimensions;Ensure;Generations;genomic profiles;Genomics;Head and Neck Squamous Cell Carcinoma;high dimensionality;Histology;Human;Image;improved;Instruction;Invaded;Knowledge;Learning;loss of function;Maps;Medical Imaging;Methods;Modality;Modeling;Morphology;multimodality;neural network;novel;Outcome;Pathologist;Patients;Pattern;Phenotype;predictive modeling;Process;Speed;Structure;Texture;Time;tool;Training;tumor;Update

PROJECT_TITLE: SCH: Counterfactual Explanations for AI-Assisted Cancer Diagnosis and Subtypiing


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Conditions Affecting the Embryonic and Fetal Periods;Fetal Alcohol Spectrum Disorders (FASD);Hearing Loss;Intellectual and Developmental Disabilities (IDD);Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Substance Misuse

ORG_CITY: OMAHA

ORG_NAME: CREIGHTON UNIVERSITY

ORG_STATE: NE

PI_NAMEs: RAGUNATHAN, PADMASHRI  (contact)

PROGRAM_OFFICER_NAME: KOVBASNJUK, OLGA NIKOLAEVNA

PROJECT_TERMS: Acoustics;Affect;Agonist;alcohol consumption during pregnancy;alcohol effect;alcohol exposure;AMPA Receptors;Animal Model;Auditory;Auditory area;Auditory Brainstem Responses;auditory deprivation;Auditory Evoked Potentials;auditory processing;Autopsy;Behavior;Brain;Brain-Derived Neurotrophic Factor;Cells;Central Auditory Processing Disorder;Child;Cognitive deficits;Communities;Dendritic Spines;Development;Electrophysiology (science);Exhibits;Fetal alcohol effects;Fetal Alcohol Exposure;Fetal Alcohol Spectrum Disorder;Flavones;Goals;Hearing;hearing impairment;Human;Impairment;in vivo;in vivo imaging;Individual;Measures;Mediating;mimetics;mouse model;Mus;Neuronal Plasticity;Neurons;Neurotrophic Tyrosine Kinase Receptor Type 2;otoacoustic emission;patch clamp;PHluorin;prenatal exposure;prepulse inhibition;preservation;Prevalence;receptor;receptor expression;receptor function;Reporting;Role;Sensorineural Hearing Loss;Sensory;Signal Transduction;Startle Reaction;Structure;Synapses;Synaptic plasticity;Synaptic Transmission;Testing;Therapeutic;trafficking;Vertebral column

PROJECT_TITLE: Effects of Prenatal Alcohol Exposure on Synaptic Plasticity and Auditory Processing


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Building Research Capacity at Institutions with Limited NIH Funding;Cystic Fibrosis;Emerging Infectious Diseases;Hearing Loss;Infectious Diseases;Kidney Disease;Lung;Neurosciences;Orphan Drug;Prevention;Rare Diseases;Rehabilitation;Tuberculosis

PI_NAMEs: NORTH, ELTON JEFFREY (contact)

PROJECT_TERMS: absorption;Acetamides;Aerobic;Affect;Age;Amikacin;Aminoglycosides;Animals;Anti-Bacterial Agents;Antibiotics;antimicrobial;Antimycobacterial Agents;Antitubercular Agents;Auditory;bactericide;Binding Proteins;Biological;Biological Assay;Biological Availability;Cell Line;Cells;Cochlea;Complex;Computer Assisted;cystic fibrosis patients;cytotoxic;cytotoxicity;Data;design;Development;drug candidate;Drug Design;drug development;Drug Kinetics;Drug resistant Mycobacteria Tuberculosis;Ensure;Evaluation;Exhibits;experience;FDA approved;Future;Gender;Genus Mycobacterium;Goals;Gram-Negative Bacteria;Hearing;hearing impairment;hearing loss risk;Human;improved;In Vitro;in vivo;Individual;Indoles;Infection;inhibitor;Kidney;Lead;lead candidate;Ligands;Lung Diseases;Membrane Proteins;Methodology;Methods;Microsomes;mouse model;Multidrug-Resistant Tuberculosis;Multiple drug resistant Mycobacteria Tuberculosis;Mus;mycobacterial;Mycobacterium abscessus;Mycobacterium Infections;Mycobacterium tuberculosis;Mycolic Acid;non-tuberculosis mycobacteria;novel;novel therapeutics;Oral;Orthologous Gene;ototoxicity;pathogen;Patients;Peripheral;Permeability;pharmacologic;Plasma Proteins;prevent;Property;Race;Running;Series;side effect;small molecule;Solubility;System;systemic toxicity;Testing;Toxic effect;tubular necrosis;Vertigo;Zebrafish

PROJECT_TITLE: Development of Novel Therapeutics for Treatment of Mycobacterial Infections


PHR: PROJECT NARRATIVE Dysregulated high-density lipoprotein (HDL) levels are strongly correlated with an increased risk of cardiovascular diseases, including Abdominal Aortic Aneurysm (AAA). The use of biomimetic synthetic HDL (sHDL) nanoparticles has been shown to be effective in addressing this risk; however, the mechanism by which sHDL exerts its protective effects in AAA remains unknown. This work aims to describe how AAA pathogenesis is altered by treatment with sHDL, providing critical information for the development of therapeutics aimed at attenuating AAA pathogenesis.

PI_NAMEs: GUO, YANHONG  (contact);SCHWENDEMAN, ANNA

PROGRAM_OFFICER_NAME: DANTHI, NARASIMHAN

PROJECT_TERMS: Abdominal Aortic Aneurysm;Address;Anti-Inflammatory Agents;Aorta;Attenuated;Biomimetics;Blood Vessels;cardiovascular disorder risk;Chronic;Clinical Trials;Death Rate;Development;Diameter;effective therapy;Endothelial Cells;Extracellular Matrix Degradation;FDA approved;Formulation;High Density Lipoproteins;In Vitro;Inflammation;insight;Life;Macrophage;mouse model;nanolipoprotein particles;nanotherapeutic;particle;Pathogenesis;Phospholipids;Play;protective effect;Risk;Role;Rupture;Smooth Muscle Myocytes;Therapeutic;therapeutic development;vascular inflammation;Vascular Smooth Muscle;Work

PROJECT_TITLE: Development of phospholipid-based nanotherapeutics for treating abdominal aortic aneurysm

STUDY_SECTION: TDPS

STUDY_SECTION_NAME: Therapeutic Development and Preclinical Studies Study Section[TDPS]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Kidney Disease;Transplantation

ORG_CITY: PHILADELPHIA

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

PHR: Acute kidney injury (AKI) is a severe disease characterized by sudden deterioration of kidney function. The kidney is an active organ relying on energy produced by mitochondria (cell powerhouse). Non-treated AKI leads to end-stage renal disease; in the application, we will deliver competent mitochondria as a new therapeutic strategy to restore kidney cells function.

PI_NAMEs: BOUCHAREB, RIHAB  (contact)

PROGRAM_OFFICER_NAME: SADUSKY, ANNA BURKART

PROJECT_TERMS: absorption;Acute;Acute Renal Failure with Renal Papillary Necrosis;Area;Azotemia;Blood Platelets;Cardiovascular system;cell dedifferentiation;Cell Physiology;Cell Proliferation;Cells;Chronic Kidney Failure;Cisplatin;Collaborations;Critical Care;cytochrome c oxidase;Cytoplasm;Deterioration;Diabetes Mellitus;Dialysis procedure;Disease;Drug toxicity;Electrical Resistance;Electrolyte Disorder;Encapsulated;End stage renal failure;Endocytosis;Epithelial Cells;Etiology;Event;Excretory function;Faculty;fatty acid oxidation;Fluorescence;fluorescence imaging;Glucose;Growth;Health;Heart;Heart failure;Heart Valve Diseases;Hepatocyte;Hospitalization;Human body;Hypoxia;In Vitro;in vivo;Incidence;Injury;Injury to Kidney;innovation;insight;Interstitial Nephritis;Ions;ischemic injury;Kidney;kidney cell;Kidney Diseases;Lead;Malignant Breast Neoplasm;Measures;Medicine;member;microvesicles;Mitochondria;mitochondrial dysfunction;mitochondrial permeability transition pore;Morbidity - disease rate;mortality;Myocardial Ischemia;Nanotubes;Nephrology;novel strategies;novel therapeutic intervention;Nutrient;Organ;oxidant stress;Oxygen Consumption;Patients;Pharmaceutical Preparations;pharmacologic;Positioning Attribute;prevent;Prevention strategy;Process;Production;Prognosis;Protein Synthesis Inhibition;Reactive Oxygen Species;Recovery;Renal function;renal ischemia;Renal Replacement Therapy;response to injury;sensor;Source;Structure;Testing;Therapeutic;Therapeutic Intervention;therapeutically effective;Tight Junctions;Tissues;tool;Transmission Electron Microscopy;Transplantation;Tubular formation;ultra high resolution;uptake;Uremia;Vesicle;Visualization

PROJECT_TITLE: Platelet-mitochondria transplantation to treat mitochondrial dysfunction in acute kidney injury

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Childhood Obesity;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: Aurora

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE This study will identify multi-level (e.g., individual, household, neighborhood, school/community) correlates and consequences of food insecurity in households (n=627) with racially/ethnically diverse children ages 5-16. Using mixed-methods (e.g., ecological momentary assessment (EMA), biomarkers, Geographical Information Services (GIS) data, focus groups), this study will examine when and how cardiometabolic risk emerges from food insecurity in childhood, mechanisms/pathways between food insecurity and cardiometabolic health, and multi-level factors that buffer against or exacerbate food insecurity to inform multi-sector interventions.

PI_NAMEs: BERGE, JERICA M (contact)

PROGRAM_OFFICER_NAME: PRATT, CHARLOTTE A

PROJECT_TERMS: Address;Adolescence;Adolescent;Adolescent obesity;Adult;Affect;Age;Biological Markers;Body Composition;Body fat;Body measure procedure;Buffers;Cardiometabolic Disease;cardiometabolic risk;cardiometabolism;Cardiovascular Diseases;Cardiovascular Physiology;Child;Child Behavior;Child Health;Child Rearing;Childhood;cohort;Communities;community organizations;community setting;coping;COVID-19;COVID-19 pandemic effects;cytokine;Data;design;Development;Diet;dietary;Disparity;Ecological momentary assessment;economic impact;Environment;ethnic diversity;experience;Exposure to;Family;feeding;Focus Groups;Food;food environment;food insecurity;Functional disorder;Future;Geography;Health;Health behavior;Health Personnel;Healthcare;Household;Hydrocortisone;improved;Individual;Inflammation;Information Services;innovation;Intervention;Knowledge;Life;longitudinal, prospective study;Low income;Measurement;Measures;Mediating;Mediator;Metabolic;Metabolic Diseases;Methodology;Methods;Morbidity - disease rate;mortality;Neighborhoods;nutrition;Obesity;obesity in children;obesity risk;Oxidative Stress;pandemic disease;Parenting Education;Parents;Pathway interactions;Personal Satisfaction;Physical activity;Physiology;Policies;Policy Developments;prevent;Price;prospective;Prospective Studies;protective factors;Puberty;Public Health;racial diversity;Resources;Risk;Risk Factors;Role;Schools;Science;Secure;Severities;Sleep;Staging;Stress;Stressful Event;Structural Racism;Surveys;therapy development;Time

PROJECT_TITLE: Examining Pathways Between Food Insecurity and Cardiometabolic Health in Diverse Children and Adolescents

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


ADMINISTERING_IC: EB

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cardiovascular;Clinical Research;Heart Disease;Heart Disease - Coronary Heart Disease;Lung;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Osteoporosis;Prevention

ORG_CITY: SANTA CRUZ

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF CALIFORNIA SANTA CRUZ

PHR: PROJECT NARRATIVE The proposed research will apply a novel dual-layer x-ray detector for calcium scoring to enable early detection and intervention of cardiovascular disease, especially when patients are asymptomatic. Our technology, which innovatively combines material engineering to tune electro-optical properties of chalcogenide alloys, detector structure design, and artificial intelligence-guided image processing, brings much-needed quantitative capabilities to x-ray imaging. This approach will allow accurate quantification of coronary artery calcium from chest x-rays and will have immense impact on proactive healthcare, improving the clinical outcomes of patients, and reducing the number of deaths associated with cardiovascular disease.

PI_NAMEs: ABBASZADEH, SHIVA  (contact);WANG, ADAM S

PROGRAM_OFFICER_NAME: KING, RANDY LEE

PROJECT_TERMS: Alloys;Arterial Fatty Streak;Arteries;Artificial Intelligence;artificial intelligence algorithm;artificial intelligence model;automated algorithm;Bone Density;calcification;Calcium;Cardiovascular Diseases;cardiovascular risk factor;Cardiovascular system;Cessation of life;Charge;Clinical;commercialization;Convection;Coronary Arteriosclerosis;coronary artery calcification;coronary artery calcium;cost;Coupled;Data;Decision Making;density;Descriptor;design;Detection;detection sensitivity;detector;Development;digital;Disease;early detection biomarkers;Early Diagnosis;Early Intervention;electric field;Engineering;Event;experience;Future;Healthcare;Heart;Heart Diseases;heart imaging;heart motion;Image;image guided;image processing;imager;Imaging Techniques;Imaging technology;improved;innovation;Location;Low Dose Radiation;lung cancer screening;machine learning algorithm;Manufacturer;Medical Imaging;Morbidity - disease rate;Morphologic artifacts;mortality;Motion;Motivation;novel;operation;Optics;Osteoporosis;Patient-Focused Outcomes;Patients;Performance;Physics;Population;population based;Predictive Factor;Preventive healthcare;Probability;Property;quantum;Radiation;radiological imaging;Research;Research Personnel;Resolution;Resource-limited setting;respiratory;Roentgen Rays;screening;segmentation algorithm;Selenium;soft tissue;standard of care;Structure;success;System;Technology;Testing;Thermal Conductivity;Thoracic Radiography;Time;Training;Tuberculosis;Vascular blood supply;X-Ray Computed Tomography;X-Ray Medical Imaging

PROJECT_TITLE: A dual-layer flat panel x-ray detector based on an engineered amorphous chalcogenide alloy for quantifying coronary artery calcium

STUDY_SECTION: ITD

STUDY_SECTION_NAME: Imaging Technology Development Study Section[ITD]


ADMINISTERING_IC: OD

FUNDING_MECHANISM: OTHERS

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Precision Medicine;Racial and Ethnic Minority Health Research;Rural Health

ORG_CITY: CORAL GABLES

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: This study will support the national goals of the AOURP study, which aims to build and maintain the largest US-based population cohort, complete with EHR records and genomics. Our specific contributions will focus on enrollment participants as part of the HEAL study engaging individuals that suffer from opioid user disorder. We will further keep engaging our existing cohort of nearly 20,000 AOURP participants and continue to educate them on the benefit and changes of AOURP.

PI_NAMEs: CARRASQUILLO, OLVEEN ;COLON, VIVIAN ;MCCAULEY, JACOB L;MELLER, ROBERT ;PEMU, PRISCILLA E;ZUCHNER, STEPHAN  (contact)

PROGRAM_OFFICER_NAME: RAHMAN, MD MIZANUR

PROJECT_TERMS: Academic Medical Centers;Address;Adoption;Advanced Malignant Neoplasm;Age;Agriculture;All of Us Research Program;Ally;Artificial Intelligence;Asian;Attention;Authorization documentation;Awareness;Baptist Church;big-data science;biobank;Biomedical Research;Black American;Black race;Calendar;cancer genetics;cancer therapy;catalyst;Categories;Child;Child health care;Childhood;Climate;Clinic;cohort;Collaborations;Collection;Communication;Communities;Community Networks;community organizations;community partners;community-centered;Comprehensive Cancer Center;Computers;Consent;Contracts;County;dashboard;Data;Data Set;data streams;Development;Devices;digital;digital measure;disability;Education;Education and Outreach;Elements;Enrollment;Ensure;Environment;Equipment and supply inventories;Equity;ethnic minority population;Ethnic Origin;Evaluation;experience;Eye diseases;Face;Faculty;Family;Feedback;Florida;follow-up;Food;Fostering;Foundations;Funding;Future;Gastrointestinal Diseases;gene therapy;Genetic;Genetic study;Geographic Locations;Geography;Goals;Greek;Health;health data;Health Personnel;Health Status;Height;Hispanic;Historically Black Colleges and Universities;Home;Hospitals;human old age (65+);Human Resources;improved;Independent Living;Individual;information gathering;Informed Consent;Infrastructure;innovation;insight;Institution;interest;Internet;Island;Joints;Language;Lead;Learning;Letters;Libraries;life span;Location;Maintenance;Marketing;Measurement;Measures;Medical;Medical center;Medical Records;Medical Research;Methodology;Modeling;Morehouse School of Medicine;novel;Nurses;outreach;outreach program;Participant;participant enrollment;participant retention;patient engagement;patient registry;Patients;Pediatric Hospitals;Personal Satisfaction;Persons;Pharmaceutical Preparations;Phase;Phenotype;Physicians;Population;population health;Population Heterogeneity;Private Hospitals;Procedures;Process;programs;Progress Reports;Protocols documentation;Public Hospitals;Puerto Rico;Race;racial minority population;Rare Diseases;Recording of previous events;Records;recruit;Regulation;Research;Research Personnel;research study;Research Support;Resources;retention rate;Role;Rotation;Rural;rural area;Saliva;Science;segregation;Self Direction;Site;Slide;social media;success;Surveys;symposium;synergism;System;telehealth;Telephone;Testing;tool;Touch sensation;Training;Transportation;Travel;Trust;trustworthiness;United States;United States National Institutes of Health;United States National Library of Medicine;Universities;Update;Vision;volunteer;Weight;Work

PROJECT_TITLE: Southeast Enrollment Center Consortium 2 (SEEC-2)


ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Narrative This research aims to enhance learning skills in a two-year post-doctoral training by promoting diversity and integrating varied backgrounds, and skills. Focused on novel imaging algorithms, the study looks for to stratify high-risk Peripheral Artery Disease (PAD) subjects, validate findings, and improve patient management.

PI_NAMEs: LIU, CHI ;MENA-HURTADO, CARLOS ;SINUSAS, ALBERT J (contact);SMOLDEREN, KIM GERMAINE

PROJECT_TERMS: Affect;Algorithms;Animal Model;Blood Vessels;Characteristics;Chronic;Clinical;clinically relevant;Collection;Communities;comorbidity;Data;Development;Diabetes Mellitus;empowerment;experience;functional decline;Functional disorder;Future;Goals;Grant;high risk;human subject;Hybrids;Image;Imaging Techniques;improved;Individual;Interdisciplinary Study;Isotopes;Knowledge;Learning;Learning Skill;Measures;novel;Outcome;Outcome Measure;Pathway interactions;Patients;Peripheral arterial disease;Population;Positioning Attribute;Positron-Emission Tomography;post-doctoral training;Postdoctoral Fellow;pre-clinical;Protocols documentation;Public Health;Quality Control;Research;Research Design;Research Project Grants;Risk;risk stratification;screening;skills;tool;Training;translational potential;Validation;Vision;X-Ray Computed Tomography

PROJECT_TITLE: Multi-isotope Hybrid PET/CT/ Imaging of Peripheral Artery Disease in Diabetes: Diversity Supplement Post Doctoral Training


PHR: PROJECT NARRATIVE Our laboratory has identified a new mechanism by which crosstalk between liver, brain, fat tissue, and kidney drives the most common form of kidney cancer, renal cell carcinoma. We have also observed that mice lose muscle mass as they develop renal cell carcinoma tumors, in a process called cancer cachexia. Work proposed in this supplement will ascertain how, and will support the work of the candidate, Andin Fosam, a rising star in the areas of muscle function, health maintenance, and cancer.

PI_NAMEs: PERRY, RACHEL JAMISON (contact)

PROGRAM_OFFICER_NAME: WILLIS, KRISTINE AMALEE

PROJECT_TERMS: Adipose tissue;African American;American;Area;Awareness;Brain;Cachexia;Cancer Cachexia;Doctor of Medicine;doctoral student;Exhibits;Fatty acid glycerol esters;FGF21 gene;fibroblast growth factor 21;functional status;Generations;Gluconeogenesis;Health;Kidney;Kidney Neoplasms;Laboratories;Liver;Maintenance;Malignant Neoplasms;mouse model;Mus;muscle form;Muscle function;novel;Oncology;parent project;Physicians;Physiological;Positioning Attribute;preservation;Process;Renal Carcinoma;Renal Cell Carcinoma;Research Personnel;Role;Scientist;skeletal muscle wasting;Testing;Tissues;translational research program;tumor;Work

PROJECT_TITLE: Defining the Role of Renal Gluconeogenesis in Renal Cell Carcinoma


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

ORG_CITY: ITHACA

ORG_NAME: CORNELL UNIVERSITY

PHR: Project narrative The proposed project uses the understanding of cell and tissue mechanics to improve cell- based immunotherapies for the treatment of solid tumors.

PI_NAMEs: WU, MINGMING  (contact)

PROGRAM_OFFICER_NAME: BECKER, STEVEN

PROJECT_TERMS: 3-Dimensional;Architecture;Biological Assay;Cells;Cellular immunotherapy;chimeric antigen receptor;chimeric antigen receptor natural killer cells;Collagen;Communities;Devices;Doctor of Philosophy;Education;Extracellular Matrix;Foundations;Frequencies;Future;Goals;graduate student;Immune;immune cell infiltrate;immunological synapse;immunoregulation;improved;Infiltration;Mammary Neoplasms;mechanical force;Mechanical Stress;Mechanics;Microfluidics;Natural Killer Cell Immunotherapy;Natural Killer Cells;neoplastic cell;Outcome;parent grant;programs;Research Project Grants;Role;Solid;Solid Neoplasm;spheroids;success;Testing;Tissues;training opportunity;tumor;tumor microenvironment

PROJECT_TITLE: Improving cell-based  immunotherapy for solid tumors using mechanical modulation


NIH_SPENDING_CATS: Biotechnology;Wound Healing and Care

PHR: PARENT AWARD R35GM118027 NARRATIVE Our work focuses on understanding how inflammation resolves and tissues are repaired in the context of human health and disease. We aim to uncover mechanisms of cell migration within tissues, the signaling networks that regulate these processes and how they are integrated during wound healing. This work will impact our understanding and treatment of autoimmune disease, diabetic and other chronic wounds, cancer and immune deficiency disorders.

PI_NAMEs: HUTTENLOCHER, ANNA  (contact)

PROGRAM_OFFICER_NAME: CHAO, CHIEN-CHUNG

PROJECT_TERMS: Affinity Chromatography;Autoimmune Diseases;Autoimmunity;Award;Biological Models;Cardiovascular Diseases;Cell Communication;cell motility;cell type;Cells;chronic wound;Complex;Cues;Defect;design;Diabetes Mellitus;diabetic;Disease;Funding;Gene Expression;genetic manipulation;genome editing;Goals;Health;Human;human disease;Imaging Device;Immunologic Deficiency Syndromes;Inflammation;Investments;Malignant Neoplasms;Mediating;Metabolism;microorganism interaction;migration;Molecular;neutrophil;novel therapeutic intervention;Optics;parent project;Pathologic;Process;repaired;Research;Research Personnel;Resolution;response;Ribosomes;Role;Signal Transduction;tissue repair;Tissues;transcriptome sequencing;Translating;Work;wound healing;Wound models;Zebrafish

PROJECT_TITLE: Cell migration and wound repair


NIH_SPENDING_CATS: Neurosciences;Nutrition;Obesity

ORG_CITY: TUCSON

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: Changes in thyroid hormone action profoundly affect both metabolism and food intake in man. Hypothyroidism results in obesity, reduced energy expenditure (EE), and hypophagia, while hyperthyroidism causes weight loss, increased EE, and hyperphagia. We discovered a novel AMPK signaling pathway that phosphorylates a specific thyroid hormone receptor (THRB2) and suppresses the thyroid axis and food intake, establishing this pathway as a central regulator of the hypothalamus and suggesting it may be dysfunctional in human obesity.

PI_NAMEs: HOLLENBERG, ANTHONY N;WONDISFORD, FREDRIC E. (contact)

PROGRAM_OFFICER_NAME: COOKE, BRAD

PROJECT_TERMS: adenylate kinase;Affect;Body Weight decreased;Cell Nucleus;Cells;Cre driver;diet-induced obesity;Eating;Energy Metabolism;Expenditure;Fasting;Feedback;feeding;Female;Functional disorder;genomic locus;Human;Hyperphagia;Hyperthyroidism;Hypothalamic structure;hypothalamic-pituitary-thyroid axis;Hypothyroidism;interest;Knock-in Mouse;Knock-out;knockout animal;Laboratories;Labyrinth;Left;Leptin;Leptin resistance;LoxP-flanked allele;male;Malnutrition;Mammals;man;Mediating;Mediator;Metabolism;mimetics;mouse model;Mus;Mutation;N-terminal;Neurons;novel;Nuclear Hormone Receptors;nutrient deprivation;nutrition;Nutritional;Obesity;Overnutrition;paraventricular nucleus;Pathway interactions;Pattern;Phospho-Specific Antibodies;Phosphorylation;Phosphorylation Site;Pituitary Gland;Protein Isoforms;reduced food intake;Regulation;Resistance;Retina;Role;Seminal;Serine;SF1;Signal Pathway;Signal Transduction;Site;Structure of nucleus infundibularis hypothalami;THRA gene;THRB gene;Thyroid Gland;Thyroid Hormone Receptor;Thyroid Hormone Resistance Syndrome;Thyroid Hormones;Time

PROJECT_TITLE: Hypothalamic regulation by thyroid hormone receptor phosphorylation

STUDY_SECTION: CSME

STUDY_SECTION_NAME: Cell Signaling and Molecular Endocrinology Study Section[CSME]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Mental Illness

ORG_CITY: BELMONT

ORG_NAME: MCLEAN HOSPITAL

ORG_STATE: MA

PHR: Project Narrative The proposed research is relevant to public health as it will provide optimized tools for mobile assessment of cognitive information processing in clinical and nonclinical populations, over time, and with greater ecological validity. The project is relevant to NIMH's mission to understand the mechanisms of complex brain disorders as it will provide tools for understanding dynamic variations in cognitive information processing of threat and how these are related to psychiatric symptoms.

PI_NAMEs: GERMINE, LAURA THI (contact)

PROGRAM_OFFICER_NAME: LEITMAN, DAVID ISAAC

PROJECT_TERMS: Acute;Address;Anxiety;Benchmarking;Brain Diseases;Characteristics;Clinical;Cognition;Cognitive;cognitive testing;cohort;Communities;Complex;design;Development;Devices;Environment;experience;field study;Frequencies;Fright;Goals;Hospitals;Hour;Individual;information processing;Infrastructure;innovation;Link;Measures;Mental disorders;Mental Health;Mission;National Institute of Mental Health;Participant;Patient Self-Report;performance based measurement;Persons;Phenotype;Population;Positioning Attribute;Post-Traumatic Stress Disorders;psychiatric symptom;Psychiatric therapeutic procedure;Psychometrics;Psychoses;Public Health;recruit;Research;Research Design;Sampling;smartphone based assessment;Specific qualifier value;Stimulus;Symptoms;Testing;Time;tool;trait;Validation;validation studies;Variant;Work

PROJECT_TITLE: Diversity Supplement: Mobile Measures of Threat Sensitivity for Cross-sectional and Longitudinal Assessment


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_NAME: BALTIMORE VA MEDICAL CENTER

PHR: HIV/AIDS affects about 37 million people worldwide including Veterans. Successful anti-HIV treatments can eliminate nearly all active viruses and prolong patients’ lives to nearly normal lifespans. However, the new challenge faced by aging patients is chronic neuroinflammation in the brain, leading to various HIV-associated neurocognitive disorders (HAND) that are found in more than 50% of HIV-infected individuals. Even under effective antiviral therapies, chronic HAND persists with high rates of delirium and dementia that can lead to suicide. According to a VA report, “the risk of suicide mortality in HIV-infected persons is 3-5 times higher than in HIV-uninfected counterparts.” What causes HAND is not well understood. Through our pilot studies, we have linked a HIV protein Vpr to HAND, and discovered a novel mechanism involving activation of the Sur1-Trpm4 channel. The goal of this proposal is to study the specific role(s) of Vpr in neuroinflammation, neurotoxicity, and viral wakening; as well as the possibility of treating HAND with a repurposed FDA-approved drug glibenclamide.

PI_NAMEs: SIMARD, J. MARC ;ZHAO, RICHARD YUQI (contact)

PROJECT_TERMS: Address;Affect;Aging;Anti-viral Therapy;antiretroviral therapy;Astrocytes;Autopsy;Binding;Biochemical;blood-brain barrier crossing;Brain;Brain Injuries;brain tissue;Cations;Cell Line;Cells;Central Nervous System;Central Nervous System Infections;chemokine;Chronic;cytokine;Data;Delirium;Dementia;experience;Extracellular Space;FDA approved;Genetic;Genetic Transcription;glial activation;Glyburide;Goals;Healthcare;HIV;HIV-1;HIV-associated neurocognitive disorder;HIV/AIDS;Human;Immune;Impairment;improved;Individual;Induced Neurons;Induction of Apoptosis;Infection;Inflammatory;inflammatory marker;Inflammatory Response;insight;International;Knockout Mice;life span;Link;Macrophage;Mediating;Mental Depression;Mental Health;Methods;Microglia;Molecular;Mus;Neurocognitive;Neurocognitive Deficit;neurocognitive disorder;Neuroglia;neuroinflammation;Neurologic;neuron apoptosis;Neurons;Neuropathogenesis;neuropathology;neurotoxic;neurotoxicity;Neurotoxins;NF-kappa B;novel;particle;Patients;Persons;Pharmaceutical Preparations;pharmacologic;Pilot Projects;Play;promoter;Proteins;reactivation from latency;Reporting;Research Priority;Residual state;Role;Severities;Source;suicidal risk;Suicide;suicide mortality;Surgeon;Testing;Therapeutic;TLR4 gene;TNF gene;Transgenic Mice;Transgenic Organisms;United States Department of Veterans Affairs;Veterans;Viral;Viral Load result;Viral Proteins;Virion;Virus;virus host interaction;Virus Replication;vpr Gene Products

PROJECT_TITLE: Viral Protein R (Vpr) in HIV-associated Brain Neuroinflammation and Neurotoxicity


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

ORG_CITY: NEW YORK

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: PROJECT NARRATIVE Early diagnosis and therapeutic intervention for the treatment of heart failure are key determinants of patient overall health. The current methods for diagnosis are restricted to detecting markers of cardiac injury and irreversible remodeling. We propose the use of 2-[18F]fluoropropionic acid-based PET to image the metabolic changes in cardiac metabolism which occur before the onset of debilitating disease.

PI_NAMEs: AZCONA, JUAN ARTURO (contact)

PROGRAM_OFFICER_NAME: WANG, WAYNE C

PROJECT_TERMS: Accounting;Acetate-CoA Ligase;Acetyl Coenzyme A;Acids;Animal Model;aorta constriction;Behavior;Biochemical Pathway;Biological Assay;Biological Markers;Bypass;Cancer Detection;cancer imaging;Cardiac;Cardiac Myocytes;cardiometabolism;Cardiomyopathies;cardiovascular health;career;Catabolism;Cells;Clinic;clinical translation;Coenzyme A;Coenzyme A Ligases;Detection;Diagnosis;Disease;dosimetry;Early Diagnosis;Echocardiography;Effectiveness;Enzymes;Event;experience;Family;Family member;fatty acid metabolism;fatty acid oxidation;Fellowship;Fluorine;Foundations;Goals;Health;Heart;heart damage;Heart Diseases;Heart failure;heart imaging;Heart Injuries;heart metabolism;Human;Image;imaging probe;Impairment;improved;In Vitro;Incubated;Intervention;Isoproterenol;Isotopes;Kinetics;Knock-out;Knowledge;Label;liquid chromatography mass spectrometry;long chain fatty acid;Malignant neoplasm of prostate;Medical;Membrane;Metabolic;metabolic imaging;Metabolism;Methods;Mitochondria;Modality;Modeling;molecular imaging;mortality;Mus;Myocardium;Organelles;Pathologic;Pathway interactions;patient prognosis;Patients;Phase;Positron;Positron-Emission Tomography;prevent;Preventive care;Propionic Acids;Reporting;Research;response;Risk;Rodent;Role;Safety;Severity of illness;Surveys;System;Testing;Therapeutic Intervention;tool;Tracer;Training;Translations;United States;uptake;Validation;Volatile Fatty Acids

PROJECT_TITLE: Imaging Incipient Heart Failure by PET

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F15-B(20)L]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Lung;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Intranasal vaccination induces populations of resident memory T cells throughout the respiratory tract that can prevent infection with respiratory viruses, including influenza virus. This proposal seeks to define the role and mechanisms of respiratory tract resident memory CD8 T cells in natural respiratory virus transmission. Our findings will provide valuable insights for vaccine development that limits the spread of respiratory viruses.

PI_NAMEs: MICHALETS, SARAH  (contact)

PROGRAM_OFFICER_NAME: ESPINOZA-PINTUCCI, MARISOL

PROJECT_TERMS: Address;Adenovirus Vector;airway epithelium;Anatomy;Animal Model;Antibodies;Antigens;Area;Attenuated;B-Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;Cellular Immunity;cytokine;Data;design;Disease Outbreaks;Disease Progression;Effectiveness;Epithelial Cells;Epitopes;Event;Ferrets;Flow Cytometry;Future;Genes;guinea pig model;Health;Hemagglutinin;Human;Humoral Immunities;IFNGR1 gene;imaging study;Immune;Immune response;Immunity;Immunize;Immunologics;in vivo;in vivo imaging;Infection;Infection prevention;Influenza;influenza infection;influenza virus strain;influenza virus vaccine;influenzavirus;insight;Interferon Type II;Knockout Mice;Knowledge;Longevity;Lower respiratory tract structure;LoxP-flanked allele;Luciferases;Lung;Mediating;Memory;Modeling;mouse model;Mucous Membrane;Mus;Nasal cavity;Nasal Epithelium;new pandemic;novel;Outcome;pandemic potential;parainfluenza virus;pathogen;Pathway interactions;Population;prevent;Production;Productivity;Proteins;Reagent;Recombinants;Reporter;Respiration;respiratory;respiratory infection virus;Respiratory System;respiratory virus;response;Role;seasonal influenza;Sendai virus;Signal Transduction;single-cell RNA sequencing;Site;Stains;Surface;Surveys;T memory cell;T-Cell Activation;T-Lymphocyte;T-Lymphocyte Epitopes;Time;tissue resident memory T cell;transcriptome sequencing;transmission process;Upper respiratory tract;Vaccination;vaccination strategy;Vaccine Design;vaccine development;Vaccines;Variant;Viral;Viral Genes;viral transmission;Virus;Virus Diseases;Virus Replication

PROJECT_TITLE: Impact of Resident Memory CD8 T Cells on Respiratory Virus Transmission


NIH_SPENDING_CATS: Cardiovascular;Heart Disease

ORG_DEPT: ANATOMY/CELL BIOLOGY

PHR: Project Narrative Post-translational modifications, or the structural modification of a protein after it is folded, of key heart contractile proteins (cMyBP-C) lead to the quick and precise regulation of the heart. These modifications appear dysfunctional in cardiac myosin binding protein-C (cMyBP-C) during heart disease. In this proposal, we aim to study the functional consequences of modifying cMyBP-C under normal conditions, elevated stress, and therapeutically treated states of the heart to better understand the consequences of these protein modifications and, ultimately, to determine if altering these modifications can lead to improved heart health.

PI_NAMEs: GREENMAN, ANGELA  (contact)

PROJECT_TERMS: Address;Adrenergic Agents;Affect;Alanine;Biological Assay;Calcium;Cardiac;Cardiac health;Cardiac Myocytes;Cardiac Myosins;cardioprotection;Cell Membrane Permeability;Cells;Contractile Proteins;Cyclic AMP-Dependent Protein Kinases;Cysteine;Data;Development;Diamond;Disulfides;Down-Regulation;Etiology;experimental study;fighting;Functional disorder;functional improvement;Gel;Glutathione;Glutathione Disulfide;Heart;Heart Diseases;Heart failure;hypertensive;improved;In Situ;In Vitro;Incubated;Individual;Ischemia;Kinetics;Knock-out;Knockout Mice;Lead;Location;Mammalian Cell;Mass Spectrum Analysis;Measurement;Measures;mechanical force;Microfilaments;Modeling;Modification;mouse model;Mus;Muscle Cells;Muscle function;Myocardial Ischemia;myosin-binding protein C;N-terminal;novel;Oxidation-Reduction;Oxidative Stress;Paste substance;Peptide Hydrolases;Permeability;Pharmaceutical Preparations;Phosphorylation;Post-Translational Protein Processing;prevent;Pro-Q aerosol foam;protein function;Proteins;Publishing;ranolazine;Rattus;Reactive Oxygen Species;Recombinants;Regulation;Relaxation;Research Proposals;response;Role;Sarcomeres;Signal Transduction;Site;Site-Directed Mutagenesis;Skin;Stains;Stress;Sulfhydryl Compounds;Tertiary Protein Structure;Testing;Therapeutic;Tobacco use;Viral;Western Blotting

PROJECT_TITLE: The role of S-glutathione in regulating cardiac myosin binding protein-C function


ORG_CITY: LOS ANGELES

ORG_NAME: VA GREATER LOS ANGELES HEALTHCARE SYSTEM

PHR: Project Narrative This study aims to improve the health and satisfaction of Veterans with chronic musculoskeletal pain by better understanding the effectiveness of five types of evidence-based complementary and integrative health, which are non-pharmacologic options to treat their pain and comorbid mental health conditions.

PI_NAMEs: TAYLOR, STEPHANIE L (contact);ZELIADT, STEVEN BACCHUS

PROJECT_TERMS: Acupuncture Therapy;addiction;Address;arm;Back;Caring;chiropracty;chronic musculoskeletal pain;Clinical;clinical care;Code;Collaborations;collaboratory;Combined Modality Therapy;comorbidity;comparative effectiveness;comparative effectiveness trial;Complementary Health;Congresses;Data;Data Collection;design;Development;dissemination strategy;Education;Effectiveness;effectiveness clinical trial;effectiveness evaluation;effectiveness measure;Electronic Health Record;evidence base;examination questions;Fatigue;Health;Healthcare;Healthcare Systems;improved;Individual;instrument;Integrative Medicine;Learning;Measurement;Meditation;Mental Health;Methods;mindfulness;Modeling;Musculoskeletal Pain;Neck;Nonpharmacologic Therapy;novel;opioid use;Outcome;Pain;Pain management;Pamphlets;Patient Outcomes Assessments;Patient-Centered Care;Patients;Personal Satisfaction;Phase;physical conditioning;Policies;pragmatic trial;prevent;Primary Care;Process;programs;Provider;Randomized;Recovery;Reporting;Research;Research Personnel;Resources;response;Review Literature;Role;Sampling;satisfaction;Self Care;Site;Standardization;Statutes and Laws;Surveys;Tai Ji;tool;treatment effect;United States National Institutes of Health;Veterans;Yoga

PROJECT_TITLE: Complementary and Integrative Health for Pain in the VA: A National Demonstration Project


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Comparative Effectiveness Research;Cost Effectiveness Research;Gene Therapy;Genetics;Health Services;Immunotherapy;Infectious Diseases;Prevention;Rare Diseases

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Chimeric antigen receptor (CAR) T-cell therapy has revolutionized the treatment of relapsed and refractory hematologic malignancies; however, the immunologic impact and risk for infections and mortality following treatment have not been well-characterized. This Career Development Award focuses on applying advanced clinical epidemiology and simulation modeling to understand the immunologic impact of CAR T-cell therapy. Our overall objective is to identify predictive risk factors and cost-effective screening methods to allow for risk stratification, protocols for immunologic monitoring, and initiation of earlier interventions to mitigate the risk for morbidity and mortality and improve quality of life.

PI_NAMEs: BARMETTLER, SARA  (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Address;Adult;Age;Antibodies;B cell therapy;B-Lymphocytes;Bayesian Analysis;Biometry;cancer diagnosis;CAR T cell therapy;career;career development;CD19 gene;Characteristics;chimeric antigen receptor;chimeric antigen receptor T cells;Clinical;clinical epidemiology;Clinical Research;clinical risk;clinically significant;cohort;Communicable Diseases;comorbidity;cost;cost effective;cost effectiveness;cost-effectiveness evaluation;Coupled;cytokine release syndrome;Data;Development;Diagnosis;Dose;Early identification;Early Intervention;Education;Environment;Epidemiology;experience;FDA approved;Frequencies;Future;General Hospitals;Goals;Health;Health Care Costs;Healthcare Systems;Hematologic Neoplasms;high risk;Hypersensitivity;hypogammaglobulinemia;Immune;Immune System Diseases;immunodeficiency;Immunoglobulins;Immunologic Monitoring;Immunologics;Immunology;Immunomodulators;Immunophenotyping;improved;improved outcome;Infection;infection risk;instructor;International;Intervention;K-Series Research Career Programs;Knowledge;Leadership;Life;longitudinal analysis;Lymphopenia;Malignant - descriptor;Malignant Neoplasms;Massachusetts;medical schools;Medicine;Mentors;Mentorship;Methods;Modeling;models and simulation;Monitor;Morbidity - disease rate;mortality;Outcome;Outcome Measure;Patient Outcomes Assessments;patient subsets;Patient-Focused Outcomes;Patients;Pediatric cohort;Peripheral;Physicians;Population;Productivity;professor;prospective;Protocols documentation;Quality of life;Questionnaires;receptor;Recommendation;Refractory;Relapse;Replacement Therapy;Research;Research Personnel;Research Proposals;Research Training;responsible research conduct;Retrospective cohort;Risk;Risk Factors;risk mitigation;risk prediction;risk prediction model;risk stratification;rituximab;Scientist;screening;Serum;Severities;sex;skills;success;Surface Antigens;Techniques;therapeutic target;Training;Training Programs;tumor;Tx receptor;Work

PROJECT_TITLE: Modeling Risk for Hypogammaglobulinemia, Infections, and Mortality with Chimeric Antigen Receptor (CAR) T-cell Therapy

STUDY_SECTION: AITC

STUDY_SECTION_NAME: Allergy, Immunology, and Transplantation Research Committee[AITC]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Colorectal Cancer;Digestive Diseases;Genetics;Human Genome;Microbiome;Prevention

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Early onset colorectal cancer occurs in individuals under age 50 and is an emerging and deadly form of colorectal cancer in the United States. Bacteria and other microbes in the colon are now thought to contribute to causing colorectal cancer. This proposal will seek to define the microbes and mechanisms leading to early onset colorectal cancer so that new ways to detect and prevent this disease can be identified.

PI_NAMEs: SEARS, CYNTHIA  (contact)

PROGRAM_OFFICER_NAME: GEORGE, CHRISTINA DAWN

PROJECT_TERMS: 16S ribosomal RNA sequencing;Acceleration;Age;Antibodies;Antibody Response;antibody test;Antigens;Bacteria;Bacterial Toxins;Bacteriophages;Binding;biological adaptation to stress;Biology;Carcinoma;cohort;Colon;colon cancer patients;Colonic Neoplasms;Colorectal Cancer;colorectal cancer screening;Control Groups;Data;Disease;early onset colorectal cancer;Ecosystem;Epidemiology;Epithelial Cells;Epithelium;Fluorescent in Situ Hybridization;Fluorescent Probes;genome wide methylation;Goals;Human;Individual;insight;Intervention;Microbe;microbial;Microbial Biofilms;microbiome;microbiota;Molecular Profiling;mouse model;Mucous body substance;Neoplastic Cell Transformation;Neoplastic Epithelial Cell;novel strategies;Onset of illness;Organism;Pathogenesis;Patients;Persons;Phage Display;Phage ImmunoPrecipitation Sequencing;Predisposition;prevent;Prevention;prospective;Public Health;Reporting;Serum;Structure;Testing;United States;Viral

PROJECT_TITLE: Pathogenesis of Early Onset Colorectal Cancer: Microbiome Contributions and Mechanisms


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Infectious Diseases;Neurodegenerative;Neurosciences

ORG_CITY: LA JOLLA

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE Alzheimer’s Disease (AD) and its precursor amnestic mild cognitive impairment (aMCI) are major public health problems that may go unidentified in persons living with HIV (PLWH) because they must often be detected against the backdrop of additional mild cognitive problems directly related to HIV termed HIV-associated Neurocognitive Disorders (HAND) that can sometimes include memory problems. The aim of this study is to identify unique profiles of memory and thinking skills, biomarkers in body fluids, and brain changes that can distinguish between aMCI and HAND in PLWH to allow us to know who has aMCI and may eventually develop AD, and who has HAND and may not develop AD. Being able to identify PLWH who have aMCI will allow for treatments and interventions better targeted for aMCI/AD in PLWH and help to reduce fears among PLWH who do not have aMCI, a significantly more debilitating disorder that confers greater risk for dementia than HAND.

PI_NAMEs: BONDI, MARK W;MOORE, DAVID J (contact)

PROGRAM_OFFICER_NAME: MARIC, MAJA

PROJECT_TERMS: Acceleration;Age;age related neurodegeneration;Aging;Agreement;Alzheimer's Disease;amnestic mild cognitive impairment;Amyloid beta-42;antiretroviral therapy;Biologic Characteristic;Biological;Biological Markers;Body Fluids;Brain;brain tissue;California;Cerebrospinal Fluid;Classification;Clinical;Cognitive;cohort;Data;Dementia;dementia risk;Deposition;Diagnosis;Diagnostic;Diagnostic Procedure;diagnostic strategy;Disease;Early Intervention;Ensure;Episodic memory;Fright;functional decline;Funding;Health Benefit;HIV;HIV diagnosis;HIV-associated neurocognitive disorder;hyperphosphorylated tau;Impairment;innovation;Intervention;late life;Life;Liquid substance;Memory;Memory impairment;Memory Loss;memory recognition;Methods;Modeling;National Institute of Mental Health;National NeuroAids Tissue Consortium;neuroAIDS;neurobehavioral;Neurobiology;Neurocognitive;Neurocognitive Deficit;Neurodegenerative Disorders;neuropathology;Neuropsychology;novel strategies;Older Population;Participant;Pathologic;Patients;performance tests;Persons;Phenotype;Plasma;programs;progression risk;prospective;Public Health;Reporting;Research;Risk;Sampling;skills;tau-1;Test Result;Therapeutic;Thinking;Tissues

PROJECT_TITLE: Disentangling Alzheimer's disease and HIV-Associated Neurocognitive Disorder: Identifying unique neuropsychological profiles with distinct biomarker and neuropathological signatures


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Depression;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Mental Illness;Neurosciences;Women's Health Research

PHR: PROJECT NARRATIVE We propose to investigate neuroimmunological and reward functions to study comorbid depression in women living with HIV (WLWH), a group heavily impacted by depression and its health consequences yet underrepresented in HIV research. This collaborative proposal bridges disciplines of depression, neuroimaging, HIV, and metabolomics in an effort to improve our understanding of neural mechanisms underlying depression in WLWH and has the potential to improve overall and mental health outcomes in this highly vulnerable group.

PI_NAMEs: GABBAY, VILMA  (contact);SHARMA, ANJALI

PROGRAM_OFFICER_NAME: RAO, VASUDEV RAMACHANDRA

PROJECT_TERMS: Address;Adult;Anhedonia;Anterior;Antioxidants;Anxiety;behavioral construct;Brain;causal model;CD4 Lymphocyte Count;cell type;child depression;Chronic;cingulate cortex;clinically relevant;cognitive function;cognitive testing;cohort;Cohort Studies;comorbid depression;computerized;Corpus striatum structure;cytokine;Data;Depressed mood;depressive symptoms;design;Diagnosis;Discipline;Epidemic;Evaluation;Exhibits;Functional Magnetic Resonance Imaging;Future;gamma-Aminobutyric Acid;Glutathione;graph theory;Health;health disparity;Heterogeneity;High Prevalence;HIV;HIV Infections;HIV Seronegativity;Immune;Immunologic Stimulation;Immunologics;improved;indexing;Inflammation;inflammatory marker;Infrastructure;Kynurenine;Learning;Machine Learning;Macrophage;Magnetic Resonance Imaging;Magnetic Resonance Spectroscopy;Measures;Mediating;Menopausal Status;Mental Depression;Mental Health;metabolomics;Modeling;monocyte;Mood Disorders;multidisciplinary;multimodality;neural circuit;neurochemistry;neuroimaging;Neuroimmune;neuroimmunology;neuromechanism;Neurotransmitters;nicotine use;Nucleus Accumbens;Outcome;Oxidative Stress Induction;Participant;Pathway interactions;Peripheral;Persons;Phenotype;Poverty;Process;Protons;Reporting;Research;response;Rest;reward anticipation;reward circuitry;reward dysfunction;Rewards;Role;Sample Size;Self Assessment;Severities;Sleep;subthreshold depression;suicidal;symptom cluster;systemic inflammatory response;Testing;The Multicenter AIDS Cohort Study;Thick;Trauma;Ventral Tegmental Area;Vulnerable Populations;Woman;Women's Interagency HIV Study;women's outcomes;Work;Youth

PROJECT_TITLE: The Neuroimmunology of Depression in Women Living With HIV


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Mental Health;Telehealth

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: PROJECT NARRATIVE Mobile app mental health interventions are accessible and effective when used at the recommended dose; but when implemented in routine care, patients do not stay engaged long enough to see clinical benefits. The proposed research evaluates what drives patient engagement and tests the impact of two strategies— automated motivational push messaging and coach support—to improve engagement with an evidence-based mobile app intervention for depression and/or anxiety. Findings will lay the foundation for a program of research focused on optimizing mobile app interventions for engagement and effectiveness.

PI_NAMEs: LIPSCHITZ, JESSICA MORROW (contact)

PROGRAM_OFFICER_NAME: SWEENEY, MARY MARGARET

PROJECT_TERMS: Adoption;Anxiety;arm;Attitude;Automobile Driving;Clinical;Clinical effectiveness;Clinical Trials;Clinical Trials Design;comorbidity;Cost of Illness;Cues;Data;Data Science;digital mental health;digital models;Dose;Effectiveness;evidence base;field study;Foundations;Goals;Habits;Human;improved;Internet;Intervention;Investigational Therapies;Light;Literature;Mental Depression;Mental Health;Methods;mobile application;Modeling;Motivation;Outcome;Outcome Measure;Participant;patient engagement;Patient Self-Report;Patients;primary care patient;programs;Protocols documentation;prototype;Provider;Psychotherapy;Randomized;Recommendation;recruit;Research;routine care;Self Efficacy;Social Facilitation;social influence;System;Technology;Testing;Time;Touch sensation;treatment adherence;user centered design

PROJECT_TITLE: Toward optimizing digital mental health interventions: A clinical trial aimed at understanding what drives patient engagement.

STUDY_SECTION: SERV

STUDY_SECTION_NAME: Mental Health Services Study Section[SERV]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Dementia;Health Services;Mental Health;Palliative Care;Patient Safety

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: PROJECT NARRATIVE Patients with dementia represent the fastest growing population of hospice users in the U.S. and account for a quarter of all hospice spending. Behavioral symptoms such as agitation, anxiety, and hallucinations are nearly universal in advanced dementia and, despite limited evidence to support their use, the mainstay of such symptom management in hospice is off-label use of psychotropic medications. Given the growing number of patients with dementia enrolling in hospice services, a better understanding of 1) the factors that influence psychotropic prescribing in hospice (including patient and caregiver preferences), and 2) the intended and unintended outcomes of such use, are critical in order to inform caregiver, provider, and policy decisions regarding appropriate use of psychotropic medications in end-of-life care for dementia.

PI_NAMEs: GERLACH, LAUREN BETH (contact)

PROGRAM_OFFICER_NAME: FAZIO, ELENA

PROJECT_TERMS: Acceleration;Accounting;Address;advanced dementia;Adverse event;Age;Agitation;anti-depressive agents;Antipsychotic Agents;Anxiety;Award;Behavior;Behavioral Symptoms;beneficiary;Benefits and Risks;Benzodiazepines;career;Caregivers;Caring;Characteristics;Clinical;clinical training;Clinical Trials;Consensus;Data;Data Set;Decision Making;Dedications;Delirium;Dementia;dementia care;design;Distress;Drug Prescriptions;Elderly;end of life;end of life care;Enrollment;Equilibrium;Evaluation;evidence base;Foundations;functional decline;Functional impairment;functional improvement;Geriatric Psychiatry;Goals;Growth;Hallucinations;Haloperidol;Hospice Care;hospice environment;hospice utilization;improved;Individual;innovation;Inpatients;Interview;K-Series Research Career Programs;Knowledge;Life;Link;loved ones;male;Measures;Medical;Medicare;Mental disorders;Mentors;Mentorship;Methods;Modeling;mortality;Mortality Decline;multilevel analysis;Nursing Homes;off-label use;older adult;Outcome;Palliative Care Nursing;Palliative Medicine;participant enrollment;Patient Care;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;Pharmacoepidemiology;Policies;Population;preference;programs;Provider;Psychiatrist;public health relevance;Qualitative Research;Quality of Care;Research;Research Methodology;Research Personnel;Risk;Scientist;Services;sex;skills;Social support;stakeholder perspectives;Standardization;Statistical Methods;Structure;Surveys;symptom management;Symptoms;Terminally Ill;Training;Training Programs;Variant;Work

PROJECT_TITLE: Medicating distress: Use of psychotropic medications among patients with dementia receiving hospice care


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science;Climate-Related Exposures and Conditions;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Effects of Household Energy Combustion;Health Effects of Indoor Air Pollution;Prevention;Social Determinants of Health

ORG_CITY: FORT COLLINS

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: COLORADO STATE UNIVERSITY

PHR: Narrative Exposure to household air pollution from primitive energy sources (such as charcoal and wood-burning stoves and kerosene lamps) is a top-ten risk factor for morbidity and mortality worldwide. This research will investigate whether a whole-house energy intervention can produce meaningful health benefits for women, men, and children in rural Rwandan homes. Outputs from this work will increase the clinical knowledge-base on the health effects on household air pollution and will generate policy-relevant information on scalable solutions to achieving cleaner, healthier forms of household energy.

PI_NAMEs: CLARK, MAGGIE LYNN (contact);VOLCKENS, JOHN

PROGRAM_OFFICER_NAME: THOMPSON, CLAUDIA L

PROJECT_TERMS: Address;Adoption;Adult;Adult women;Africa;aged;American;anthropogenesis;arm;Biomass;Blood Pressure;burden of illness;Carbon Black;Charcoal;Child;climate forcing;Clinical;clinical outcome measures;clinically actionable;Colorado;Communities;Complement;cooking;Cookstove;cost;Costs and Benefits;Country;Data;design;Development;Economics;Eligibility Determination;energy balance;Energy-Generating Resources;Ensure;Exposure to;fine particles;Gases;Goals;Growth;Guidelines;Health;Health Benefit;Heating;Home;Hour;Household;Household Air Pollution;Human;Human Rights;improved;Infrastructure;Intervention;Kerosene;knowledgebase;Lighting;Link;low and middle-income countries;male;Marketing;Measurement;Measures;men;Modeling;Modernization;Morbidity - disease rate;mortality;Natural Gas;Output;Participant;Persons;Petroleum;Planet Earth;Policies;Policy Maker;Population;prevent;Privatization;Provider;public-private partnership;pulmonary function;Randomized;Randomized, Controlled Trials;Readiness;recruit;Research;research study;response;Risk Factors;Rural;rural area;Rural Health;Rwanda;secondary endpoint;Solar Energy;solid fuel;Source;Technology;timeline;treatment arm;Universities;Woman;Wood material;Wood stove;Work;World Health Organization

PROJECT_TITLE: Sustainable Household Energy Adoption in Rwanda (SHEAR): Promoting Rural Health with Solar and Natural Gas

STUDY_SECTION: CIHB

STUDY_SECTION_NAME: Community Influences on Health Behavior Study Section[CIHB]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

PHR: PROJECT NARRATIVE The novel coronavirus 2019 (COVID) pandemic is the most significant Public Health crisis of the past century, and African-Americans are disproportionately impacted-- with rates of COVID-19 infection and mortality that are 2 to 4 times higher than those in Whites. Because most research on COVID-19 has focused on the physiological consequences of the disease, we know almost nothing about the psychosocial impact of COVID- 19, particularly in the most vulnerable groups. The goal of the proposed project is to examine the impact of COVID-related psychosocial stressors on vascular aging in a cohort of African-American women.

PI_NAMEs: LEWIS, TENÉ T (contact)

PROGRAM_OFFICER_NAME: REDMOND, NICOLE

PROJECT_TERMS: 2019-nCoV;Affect;African American;African American population;African American Women;Aging;arterial stiffness;attributable mortality;Blood Pressure;Blood Vessels;Businesses;Child;Child Rearing;cohort;Coronavirus;Country;COVID-19;COVID-19 disparity;COVID-19 impact;COVID-19 mortality;COVID-19 pandemic;COVID-19 stress;Dangerousness;Death Rate;Discipline of Nursing;Disease;Employment;experience;Exposure to;fast food;Financial Hardship;Funding;Gender;Goals;Health;Heterogeneity;Home;Individual;Inequality;infection rate;Inflammation;innovation;Life;Light;Loneliness;low socioeconomic status;maltreatment;Marital Status;Marriage;men;middle age;mortality;novel coronavirus;Occupations;optimism;pandemic disease;pandemic stress;Personal Satisfaction;Physiological;Populations at Risk;Positioning Attribute;post-COVID-19;post-pandemic;Prevention;prospective;psychosocial;Psychosocial Assessment and Care;Psychosocial Stress;psychosocial stressors;Public Health;Race;racial difference;racial disparity;Reporting;Research;resilience;resilience factor;Resources;SARS-CoV-2 infection;Schools;self-compassion;Single Parent;social stressor;Social support;sociodemographic factors;Socioeconomic Status;Stress;stressor;Time;Underemployment;Unemployment;United States;Vascular Diseases;Virus;Vulnerable Populations;Wages;White Women;Woman;Work;Workplace

PROJECT_TITLE: Psychosocial Stress due to COVID-19 and Vascular Aging in African-American Women


ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Cancer is treated with DNA damaging chemotherapy and radiation therapy (XRT). Cancer cells are sensitive to DNA damage as they divide rapidly and have often acquired mutations in mechanisms that safeguard genome stability. Immune cells are also sensitive to DNA damage as they divide extremely rapidly (<6 h). Since cancer is treated with combinations of DNA damaging chemotherapy, XRT and immunotherapy, we investigate new approaches to separate the impact of DNA damage on cancer and anti-tumor immune cells.

PI_NAMEs: BAKKENIST, CHRISTOPHER J. (contact)

PROGRAM_OFFICER_NAME: HU, ZHANG-ZHI

PROJECT_TERMS: Acceleration;Affect;Anabolism;Animals;anti-tumor immune response;Antigen Presentation;Antigens;Autoimmune Diseases;Base Pairing;Binding;Breeding;cancer cell;Cancer Model;Cancer Patient;CD28 gene;CD3 Antigens;CD8-Positive T-Lymphocytes;Cell Count;Cell Cycle;Cell Cycle Checkpoint;Cell Cycle Kinetics;Cell Death;Cell division;cell growth;cell killing;Cell Proliferation;Cells;chemotherapy;Chemotherapy and/or radiation;Clinical;Clinical Trials;Clonal Expansion;Communicable Diseases;comparison control;conditional knockout;Cyclin-Dependent Kinases;Data;Deoxyuridine;Development;DNA;DNA biosynthesis;DNA Damage;DNA Integration;DNA Repair;DNA Repair Pathway;DNA replication fork;DNA Sequence;Drug usage;Effector Cell;effector T cell;Enzymes;ETAA1;Excision;Exclusion;exhaust;experimental study;Flow Cytometry;G1 Phase;Genetic Transcription;Genome;Genome Stability;Genotype;Germ-Line Mutation;Goals;Harvest;helicase;Immune;immune checkpoint blockade;Immune response;Immunologic Memory;immunomodulatory therapies;Immunotherapy;In Vitro;in vivo;in vivo Model;Infection;inhibitor;Injections;innovation;Interferon alpha;Interferons;kinase inhibitor;Knock-out;Knockout Mice;Laboratories;Laboratory Finding;Licensing;Lymphocytic choriomeningitis virus;Malignant Neoplasms;Mediating;Memory;Memory impairment;Modeling;mouse model;Mus;Mutation;neoplastic cell;novel strategies;Nucleosides;Nutrient;Operative Surgical Procedures;parent grant;Parents;Pathway interactions;pharmacologic;Pharmacotherapy;Phenotype;Phosphorylation;Phosphotransferases;Play;Procedures;Proliferating;Protocols documentation;Publishing;radiation response;Radiation therapy;repaired;Replicon;Research;Research Design;Research Project Grants;Research Proposals;response;Ribonucleosides;RNA;Role;S phase;Schedule;Signal Transduction;Spleen;System;T cell response;T cell therapy;T memory cell;T-Cell Activation;T-Cell Development;T-Lymphocyte;Testing;Thymidine;Time;tissue culture;Training;transplant model;Transplantation;tumor;tumor microenvironment;Tumor-infiltrating immune cells;Update;Virus Diseases;Western Blotting

PROJECT_TITLE: The Impact of ATR Kinase Inhibitors on CD8+ T Cell Expansion and Memory Development

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(02)-M]


ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PI_NAMEs: PETERSON, LISA A (contact)

PROGRAM_OFFICER_NAME: CUI, YUXIA


NIH_SPENDING_CATS: Genetics;HIV/AIDS;Infectious Diseases

PHR: Proper localization of viral components in cells is critical for efficient production of virus particles and spread from infected to uninfected cells. The goal of the proposed research is to elucidate the mechanisms that direct Gag, a structural protein of HIV-1 that causes AIDS, to the proper sites within virus-expressing cells. Knowledge obtained from proposed studies will help us develop novel antiviral strategies that may either directly suppress assembly and release of HIV-1 particles or inhibit spread of this virus to uninfected host cell

PI_NAMEs: ONO, AKIRA  (contact)

PROGRAM_OFFICER_NAME: MCDONALD, DAVID JOSEPH

PROJECT_TERMS: 3-Dimensional;Ablation;Acquired Immunodeficiency Syndrome;Address;Affect;Binding;Biological Assay;CD44 gene;Cell membrane;Cell Proliferation;Cell surface;cell type;Cells;Collaborations;Complex;Cryoelectron Microscopy;Cytoplasm;Cytoplasmic Structures;Data;Environment;Event;experimental study;extracellular;follow-up;gag Gene Products;Genetic;Goals;HIV-1;Infection;Integral Membrane Protein;Integration Host Factors;Intracellular Membranes;Knowledge;Lipids;lymph nodes;Macrophage;Mediating;Membrane;Membrane Lipids;Membrane Proteins;Messenger RNA;Microscopy;Molecular;Movement;Mutagenesis;N-terminal;nanodisk;novel;overexpression;P-selectin ligand protein;particle;Phospholipids;Plasmids;prevent;Process;Production;Proline-Specific tRNA;Property;recruit;Regulation;Research;Ribosomes;RNA;RNA Binding;Role;simulation;Site;spatial relationship;Stromal Cells;structural determinants;Structural Protein;Structure;superresolution microscopy;Surface;T-Lymphocyte;Testing;Transfection;Transfer RNA;Translating;Translations;transmission process;Viral;viral genomics;viral RNA;Viral Structural Proteins;Virion;virological synapse;Virus;Virus Assembly

PROJECT_TITLE: Mechanisms that determine subcellular sites of HIV-1 assembly

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Lung;Orphan Drug;Pediatric;Prevention;Rare Diseases

ORG_DEPT: PEDIATRICS

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative The Paramyxoviridae family includes several pathogenic viruses that pose major threats to human health, including human parainfluenza virus 3 (HPIV3) which causes illness or death in millions of infants and young children, and the lethal Nipah (NiV) and Hendra (HeV) viruses that pose a risk of global emergence. We propose to apply the results of our fundamental research to advance a potent new antiviral strategy that is based on the use of fusion-inhibitory peptides to block viral entry.

PI_NAMEs: MOSCONA, ANNE  (contact)

PROGRAM_OFFICER_NAME: DAVIS, MINDY I

PROJECT_TERMS: Accidents;acute toxicity;African Green Monkey;Amino Acids;Animal Model;Animals;Anti-viral Agents;anti-viral efficacy;Anti-viral resistance;Antibodies;appendage;base;Binding Proteins;Biodistribution;Biological Assay;Brain;Bronchiolitis;Cell membrane;Cells;Cessation of life;Child;Childhood;Chimeric Proteins;Clinical;combat;Complex;conformational conversion;Cotton Rats;Croup;design;Drug Kinetics;efficacy evaluation;efficacy study;Ensure;env Gene Products;Evolution;experimental study;Family;Finding by Cause;fundamental research;Glycoproteins;Goals;Half-Life;Health;Hemagglutinin;Hendra;Hendra Virus;Henipavirus;Human;human disease;immunogenicity;improved;In Vitro;in vivo;Infant;Infection;Inhalation;Inhalation Drug Administration;inhibitor;innovation;Interruption;Lead;lead candidate;Lipids;Lung;Mediating;Membrane;Membrane Fusion;Mesocricetus auratus;Methods;Modeling;Modification;Molecular;Molecular Conformation;Mutation;Neuraminidase;Nipah Virus;Nose;novel;Organoids;Para-Influenza Virus Type 3;parainfluenza virus;Paramyxovirus;passive immunoprophylaxis;pathogenic virus;Peptide Hydrolases;Peptides;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;Pneumonia;Positioning Attribute;Preparation;prevent;Property;prophylactic;protein aminoacid sequence;Proteins;prototype;receptor binding;Receptor-Interacting Protein;Resistance;Resistance development;resistance mechanism;respiratory virus;Risk;Rodent;Self Administration;Series;Site;Structure;Structure of parenchyma of lung;System;Therapeutic;Tissue Model;Tissues;transmission process;vaccine access;Validation;Vertebral column;Viral;viral entry inhibitor;Viral Physiology;viral resistance;Virus

PROJECT_TITLE: Broad spectrum inhibitors of paramyxovirus envelope proteins

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DCAI-B(82)]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Radiation Oncology;Women's Health Research

ORG_CITY: FAIRFAX

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: GEORGE MASON UNIVERSITY

ORG_STATE: VA

PHR: We have discovered a new mitochondrial metabolic adaptation process, called secretory mitophagy, that is used by cancer cells to survive under stress of chemotherapy, radiotherapy, and molecular therapy. Under the Aims we will explore the molecular controls of this process in vitro, and in vivo, because it constitutes a new therapeutic target, and a clinically-relevant means to monitor the ongoing efficacy of cancer therapy. We will further investigate the tumor microenvironment response to cancer cell secretory mitophagy induced by increased oxidative stress.

PI_NAMEs: HOWARD, MARISSA ASHTON (contact)

PROGRAM_OFFICER_NAME: WALLACE, TIFFANY A

PROJECT_TERMS: 4T1;Autophagocytosis;Autophagosome;Award;bafilomycin A1;Biogenesis;Biological;Breast Cancer cell line;cancer cell;Cancer cell line;cancer therapy;Cell Survival;Cells;Chemicals;chemotherapy;Chloroquine;Clinical;clinically relevant;Culture Media;DNA Damage;Docking;experimental study;extracellular vesicles;graduate student;Grant;Human;Hypoxia;Immunotherapy;In Vitro;in vivo;in vivo monitoring;Intercellular Fluid;knock-down;Laboratories;Learning;Length;Link;Lysosomes;Macrophage;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Neoplasms;Mass Spectrum Analysis;MDA MB 231;Measurement;Mentors;Metabolic;Methods;Mitochondria;Mitochondrial DNA;Mitochondrial Proteins;mitochondrial therapeutics;Molecular;Molecular Analysis;Monitor;Mus;neoplastic cell;new therapeutic target;Organelles;Outcome;Oxidative Stress;Oxidative Stress Induction;Pathway interactions;Peripheral;Phenotype;PINK1 gene;pressure;Process;Protein Export Pathway;Proteins;Radiation therapy;Reagent;real time monitoring;receptor expression;Research;response;Role;Scientist;Secretory Cell;sensor;Sirolimus;skills;Solid Neoplasm;Stress;System;Testing;therapeutic target;therapy resistant;tool;triple-negative invasive breast carcinoma;tumor;tumor microenvironment;tumor progression;Western Blotting

PROJECT_TITLE: Secretory Mitophagy in Cancer Metabolic Reprogramming


NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics;Ovarian Cancer;Prevention;Rare Diseases;Women's Health Research

ORG_CITY: SAN DIEGO

ORG_DEPT: BIOLOGY

ORG_NAME: SAN DIEGO STATE UNIVERSITY

PHR: Narrative Ovarian cancer is usually diagnosed at a late stage when survival is only about 10%, rendering this disease the deadliest gynecological malignancy. Disease recurrence is the major cause of mortality and despite a greater understanding of ovarian cancer biology there have been no significant improvements in mortality rates in the last five decades. Investigation of tumor cells that are resistant to chemotherapy and have the capacity to regenerate tumors is crucial for achieving cures for ovarian cancer patients.

PI_NAMEs: HOUSE, CARRIE DANIELLE (contact)

PROGRAM_OFFICER_NAME: BERA, TAPAN K

PROJECT_TERMS: Address;Adhesions;Adipocytes;Adjuvant Chemotherapy;Analysis of Variance;Animals;anti-cancer research;Biological;biological adaptation to stress;Biological Assay;Blinded;Blood Banks;Cancer Biology;cancer cell;cancer imaging;Cancer Patient;Cancer Relapse;cancer survival;Carboplatin;Cell Culture Techniques;cell motility;Cell Physiology;Cell Separation;Cells;Cellular biology;cellular imaging;Cellular Spheroids;Characteristics;Chemoresistance;Chemotactic Factors;chemotherapy;Clinical Data;Clustered Regularly Interspaced Short Palindromic Repeats;Coculture Techniques;cohort;Combined Modality Therapy;Competence;Control Groups;Cultured Cells;Cytotoxic Chemotherapy;Data;Death Rate;Diagnosis;Disease;Disease remission;Disease Resistance;doctoral student;drug relapse;Drug resistance;Environment;Evaluation;experience;experimental group;experimental study;Family;Family member;Fellowship;Female;Fibronectins;Flow Cytometry;Future;Genes;Goals;Greater sac of peritoneum;Hand;Harvest;Immune response;Immunohistochemistry;improved;In Vitro;in vitro testing;in vivo imaging system;in vivo Model;inhibitor;Injections;Insulin-Like Growth Factor I;Integrins;interest;intraperitoneal;Intraperitoneal Injections;Invaded;Investigation;knock-down;Knock-out;Knowledge;Label;Luciferases;Macrophage;Malignant Female Reproductive System Neoplasm;Malignant neoplasm of ovary;Malignant Neoplasms;matrigel;Measurement;Mediating;Mesothelium;metabolic profile;migration;Modeling;Monitor;monolayer;mortality;mouse model;Mus;Natural regeneration;Neoadjuvant Therapy;Neoplasm Metastasis;neoplastic cell;NF-kappa B;novel;Nude Mice;Nutrient;Paclitaxel;parent grant;Pathway interactions;Patients;Peripheral Blood Mononuclear Cell;Pharmaceutical Preparations;Phenotype;power analysis;Process;programs;Proliferating;Property;Protocols documentation;Publications;Publishing;Recurrent disease;Relapse;relB protein;Research;Research Activity;research study;Resected;Resistance;response;Role;Sample Size;Signal Pathway;Signal Transduction;Site;skills;spheroids;Statistical Data Interpretation;stem;stemness;Stress;stressor;Students;subcutaneous;Subcutaneous Injections;Suspensions;targeted treatment;Testing;Therapeutic;Tissues;Training;transcription factor;transcriptome sequencing;Transplantation;treatment strategy;tumor;tumor initiation;tumor progression;Tumorigenicity;United States;vector control;Water;Work;Writing;Xenograft procedure

PROJECT_TITLE: Alternative NF-kB activation in post-chemotherapy setting to elucidate novel mechanisms of ovarian cancer relapse


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Colorectal Cancer;Complementary and Integrative Health;Digestive Diseases;Genetics;Human Genome;Microbiome

ORG_CITY: SAN FRANCISCO

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE – NO CHANGES FROM PARENT GRANT Rigorous experiments from our lab and others have shown that human gut bacteria can metabolize numerous anticancer drugs; however, the major bacterial species that influence drug metabolism in patients, the genes and enzymes responsible, and the consequences for drug pharmaco-kinetics and -dynamics (PKPD) remain unknown. Here, we propose a series of in vitro and in vivo experiments to dissect the human gut bacterial species, genes, and enzymes responsible for the metabolism of the oral fluoropyrimidine capecitabine and their downstream consequences for drug PKPD in mice. Due to our focus on drugs used as current standard of care and naturally occurring bacterial species prevalent in the human gut microbiota, this preclinical research program is highly synergistic with ongoing clinical studies of cancer patients conducted by our team and the broader microbiome field.

PI_NAMEs: TURNBAUGH, PETER JAMES (contact)

PROGRAM_OFFICER_NAME: RASOOLY, AVRAHAM

PROJECT_TERMS: Antibiotics;Antineoplastic Agents;Attention;Bacterial Genes;Biochemical;Biological Assay;Biological Availability;Biological Markers;Body Weight decreased;cancer cell;Cancer Patient;cancer therapy;capecitabine;Cells;Clinical Research;Clinical Trials;clinically relevant;colon cancer patients;colorectal cancer treatment;Coupled;Data;design;Disease Marker;Dose;drug disposition;drug efficacy;Drug Kinetics;drug metabolism;Drug toxicity;Drug usage;Enzymes;Escherichia coli;experimental study;fluoropyrimidine;Fluorouracil;Genes;Gnotobiotic;Goals;Growth;gut bacteria;gut microbiome;gut microbiota;Hepatocyte;Histologic;Human;Immunologic Markers;Immunotherapy;Impairment;improved;In Vitro;in vivo;Inflammatory Bowel Diseases;insight;inter-individual variation;Intestines;Life;Malignant Neoplasms;Metabolic Biotransformation;Metabolic Pathway;Metabolism;microbial;Microbiology;microbiome;mouse model;Mus;Mutagenesis;Nature;Operon;Oral;Oral Administration;overexpression;parent grant;parent project;Pathway interactions;Patients;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;Physiological;pre-clinical;pre-clinical research;Prevalence;primary endpoint;Probiotics;Prodrugs;programs;Publishing;Randomized, Controlled Trials;Research;response;Role;Series;side effect;Source;standard of care;Streptomycin;Study models;Taxon;Testing;Therapeutic;Therapeutic Effect;Toxic effect;Treatment outcome;tumor growth;tumor metabolism;Work;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Metabolism of cancer chemotherapeutics by the human gut microbiome

STUDY_SECTION: CPSS

STUDY_SECTION_NAME: Cancer Prevention Study Section[CPSS]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Immunization;Infectious Diseases;Prevention;Vaccine Related

ORG_DEPT: CHEMISTRY

PHR: Project Narrative The coronavirus SARS-CoV2 emerged in late 2019, and caused a global pandemic resulting in over 3.5 million deaths worldwide. In the search for molecules that can be used to inhibit coronaviruses, the carbohydrate binding protein BOA was discovered to inhibit SARS-CoV2 infection at low nanomolar concentrations. The research proposed here is to understand the mechanism by which BOA inhibits SARS-CoV2 infection and demonstrate that BOA can inhibit emerging variants of concern as well as related beta-coronaviruses.

PI_NAMEs: GUSEMAN, ALEX JOSEPH (contact)

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TERMS: 2019-nCoV;ACE2;Animal Model;Antibodies;Award;betacoronavirus;Binding;Biochemical;Biological Assay;Biophysics;Burkholderia;carbohydrate binding protein;carbohydrate receptor;career;career development;Cells;Cessation of life;Clinic;combat;Communication;convalescent plasma;Coronavirus;Coronavirus spike protein;COVID-19;COVID-19 vaccine;Dangerousness;Data;design;Development Plans;Diagnostic;diagnostic development;Disease;Educational workshop;Electron Microscopy;Emerging infection;emerging virus;experimental study;Family;FDA Emergency Use Authorization;fighting;Future;glycosylation;Grant;Health;Health Personnel;HIV;HIV Envelope Protein gp120;Homologous Gene;Human;human coronavirus;Immune;Incentives;Infection;inhibitor;Institution;instrumentation;Intervention;Knowledge;Lead;Lectin;Left;light scattering;Lilium;Link;Mannose;Mediating;member;Membrane Fusion;Mentorship;Middle East Respiratory Syndrome Coronavirus;Molecular Conformation;Molecular Sieve Chromatography;Mutation;nanomolar;neutralizing antibody;novel;novel coronavirus;pandemic disease;pandemic potential;Pharmacologic Substance;Phase;Polysaccharides;prevent;Process;Proteins;receptor;receptor binding;Research;Resources;Respiratory Disease;Risk;SARS coronavirus;SARS-CoV-2 infection;SARS-CoV-2 inhibitor;SARS-CoV-2 spike protein;SARS-CoV-2 variant;Science;skills;Solvents;Spanish flu;Specificity;structural biology;Structure;Surface;symposium;Testing;Therapeutic;Therapeutic antibodies;therapeutic development;Training;Treatment Efficacy;Universities;Vaccination;Vaccine Research;Vaccines;Variant;variants of concern;Viral;viral entry inhibitor;Viral Genome;Virion;virology;Virus;Virus Diseases;weapons;Work;Writing

PROJECT_TITLE: Developing Lectins as Inhibitors of Coronavirus Spike Proteins