NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Neurosciences;Substance Misuse;Tobacco

ORG_CITY: NEW HAVEN

ORG_DEPT: PSYCHIATRY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Narrative Nicotine addiction is responsible for the recent increase in vaping, and also drives tobacco smoking, the major preventable cause of death in the United States. One reason nicotine is addictive is because it makes other rewards feel even better. We will identify new brain mechanisms through which nicotine enhances experience of other rewards, and using molecular techniques, we will determine how these pathways contribute to behaviors related to nicotine addiction.

PI_NAMEs: PICCIOTTO, MARINA R (contact)

PROGRAM_OFFICER_NAME: WU, DA-YU

PROJECT_TERMS: Acceleration;Acetylcholine;Acute;addiction;Amygdaloid structure;Anatomy;Area;Automobile Driving;basal forebrain;Basal Nucleus of Meynert;Behavior;Behavioral;behavioral study;Brain;Calcium;Cause of Death;cell type;Cells;cholinergic;Cholinergic Receptors;conditioned place preference;Coupled;Cues;Data;Desire for food;Development;Dopamine;dopaminergic neuron;drug of abuse;Electrophysiology (science);epigenomics;Euphoria;Evaluation;Exhibits;experience;experimental study;Female;Food;Funding;gamma-Aminobutyric Acid;genetic approach;Globus Pallidus;Human;human subject;in vivo;Learning;Light;male;Mediating;Molecular;Molecular Genetics;Morphology;Motivation;Mus;neurobiological mechanism;Neuronal Plasticity;Neurons;Nicotine;Nicotine Dependence;nicotine exposure;nicotine reward;nicotine use;Nicotinic Receptors;novel;optogenetics;Pathway interactions;Pharmaceutical Preparations;Pharmacology;postsynaptic;Predisposition;Process;Property;Proteome;Proteomics;Psychological reinforcement;Rattus;reinforcer;Relapse;Research;response;Rewards;Rodent;Role;Sensory;sex;Signal Pathway;Signal Transduction;Slice;Smoking;Stimulus;Stress;Techniques;Tobacco smoke;Tobacco smoking behavior;transcriptomics;United States;vaping;Ventral Tegmental Area;Work

PROJECT_TITLE: Anatomical Basis for Nicotine Addiction


ADMINISTERING_IC: DK

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_COUNTRY: UNITED STATES

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_FIPS: US

PHR: PROJECT NARRATIVE We have recently discovered that human deceased-donor kidney allografts produce fibrinogen in response to cold-storage, which can cause pathologic plugging of microvasculature upon reperfusion via local aggregation of red-blood cells (rouleaux formation). In this grant, we will: 1) Define the mechanisms that drive this fibrinogen stress response during cold-storage; and 2) Develop pre-transplant therapeutic strategies to ameliorate this pathology during ex vivo organ perfusion. All work will be performed using a well-established pipeline for human tissues (transplant-declined human organs and clinical biopsy specimens) to ensure that successful completion of our aims will translate rapidly into reduced mortality for kidney-transplant patients.

PI_NAMEs: KULKARNI, SANJAY ;POBER, JORDAN S (contact)

PROGRAM_OFFICER_NAME: ABBOTT, KEVIN C

PROJECT_TERMS: Acute-Phase Proteins;Aging;Area;biobank;biological adaptation to stress;Biological Assay;Biopsy;Biopsy Specimen;Blood Vessels;Cells;Clinical;Collaborations;comorbidity;Cryopreservation;cytokine;delayed graft function;Development;Donor person;Enzyme-Linked Immunosorbent Assay;Erythrocytes;experimental study;Extrahepatic;Fibrinogen;genomic platform;Geographic Locations;glomerular filtration;Glomerular Filtration Rate;Goals;Grant;Hepatic;Histopathology;Human;human tissue;Image;improved;in vivo;Injury;Interleukin-6;Kidney;kidney allograft;kidney cortex;Kidney Transplantation;Knowledge;Mediating;Mediator;Methods;Molecular;mortality;natural hypothermia;normoxia;Organ;Organ Culture Techniques;Organ Donor;organ injury;Organ Transplantation;Outcome;Pathologic;Pathology;Patients;Perfusion;Persons;pharmacologic;Physiological;Plasminogen;post-transplant;Predisposition;Prevention;Production;Proteins;Quantitative Microscopy;Regimen;Renal function;repaired;Reperfusion Therapy;Research;resilience;response;restoration;Scientist;Shock;single-cell RNA sequencing;Specimen;targeted treatment;Testing;Therapeutic;therapeutic development;tissue culture;Tissues;TNF gene;Transcript;transcriptome sequencing;Translating;Translations;Transplant Recipients;Transplantation;Tubular formation;Urine;wasting;Work;X-Ray Computed Tomography

PROJECT_TITLE: Mechanisms and Ex Vivo Repair of Cold-Storage Injury in Human Kidney Allografts

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: FORT COLLINS

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: COLORADO STATE UNIVERSITY

ORG_STATE: CO

PHR: The proposed research studies the function of a newly discovered neuronal organelle that is damaged following ischemic stroke. Completion of the proposed research will expand our basic understanding of neuron biology and may lead to new strategies for the treatment of stroke.

PI_NAMEs: HOPPA, MICHAEL BLAKE;TAMKUN, MICHAEL M. (contact)

PROGRAM_OFFICER_NAME: MATOS GALICIA, HEIDI YANICE

PROJECT_TERMS: Actins;Action Potentials;Adrenergic Receptor;Affect;Axon;Binding;Biology;Brain;C-terminal;Cell membrane;Cell surface;cell type;Cells;Cellular biology;Chimera organism;Coupled;Data;Dendrites;Developmental Delay Disorders;Diffusion;Dominant-Negative Mutation;Endoplasmic Reticulum;epileptic encephalopathies;Exocytosis;experimental study;Glutamates;Goals;Hippocampus;Homeostasis;Human;human disease;Hyperactivity;Hypoxia;Image;Ions;Ischemia;Ischemic Stroke;knock-down;Kv2.1 channel;large-conductance calcium-activated potassium channels;Length;Link;Lipids;Literature;Mammals;Mediating;Membrane;Membrane Potentials;Membrane Proteins;Molecular;Monitor;mutant;Mutation;neuronal cell body;Neurons;Nonsense Codon;novel;novel therapeutic intervention;Organelles;Pattern;Phosphatidylinositol 4,5-Diphosphate;Physiology;Play;Point Mutation;Population;Potassium Channel;presynaptic;Presynaptic Terminals;prevent;Property;Proteins;Rattus;reconstitution;Recovery;Regulation;Research;research study;Role;Scaffolding Protein;sensor;Signal Transduction;Signaling Protein;Sirolimus;Site;small hairpin RNA;SNAP receptor;stem;Stroke;stroke therapy;stroke-like episode;Structure;superresolution imaging;Surface;Synaptic Vesicles;System;Testing;Transfection;Vesicle;voltage;Voltage-Gated Potassium Channel;Work

PROJECT_TITLE: Neuronal Cell Biology of Kv2.1-induced Endoplasmic Reticulum/Plasma Membrane Contact sites

STUDY_SECTION: SYN

STUDY_SECTION_NAME: Synapses, Cytoskeleton and Trafficking Study Section[SYN]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Biotechnology;Facioscapulohumeral Muscular Dystrophy;Genetics;Muscular Dystrophy;Orphan Drug;Rare Diseases

ORG_CITY: RENO

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF NEVADA RENO

ORG_STATE: NV

PHR: NARRATIVE Facioscapulohumeral Muscular Dystrophy (FSHD) is a severely debilitating disease affecting males and females of all ages. The goal of this proposal is to identify factors selectively responsible for pathogenic gene expression leading to FSHD, characterize their roles in vertebrate and muscle development, and validate them as viable therapeutic targets. A specific and practical means of reducing pathogenesis in FSHD is critically needed for an effective therapy.

PI_NAMEs: JONES, PETER L (contact)

PROGRAM_OFFICER_NAME: CARIFI, EMILY FORAN

PROJECT_TERMS: 4q35;Address;Adult;Affect;Age;Animal Model;Animal Muscular Dystrophy;Artificial Human Chromosomes;ASH1L gene;Automobile Driving;Biological;Biological Assay;causal variant;Cells;Chromatin;Chromatin Remodeling Factor;Chromosomes;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;D4Z4;Development;diagnostic assay;Disease;Distal;effective therapy;Engraftment;Enhancers;Epigenetic Process;Facioscapulohumeral Muscular Dystrophy;Female;Funding;Gene Expression;Gene Expression Profile;Genes;Genetic;Genome;Goals;Health;Human;in vivo;insight;knock-down;male;Mediating;Modeling;mouse model;Mus;Muscle;Muscle Cells;Muscle Development;Muscle Fibers;Myoblasts;Myopathy;Natural regeneration;new therapeutic target;novel;Pathogenesis;Pathogenicity;Pathology;Pathway interactions;Patients;prevent;Proteins;Regulation;Relaxation;Reporter;Repression;Role;Severities;Skeletal Muscle;SMARCA5 gene;Specificity;targeted treatment;Testing;Therapeutic;therapeutic development;Therapeutic Intervention;therapeutic target;Tissues;Transgenic Organisms;translational potential;Validation;virulence gene;Xenograft procedure

PROJECT_TITLE: Mechanisms of DUX4 mediated FSHD pathology


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Dementia;Neurodegenerative;Neurosciences;Rehabilitation

ORG_CITY: DURHAM

ORG_DEPT: NEUROSURGERY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Alzheimer's disease is a progressive degenerative disorder with limited treatments. Our hypothesis is that transcranial alternative current electrical stimulation (tACS) can improve Alzheimer's disease progression through improving impaired metabolism. We will apply tACS to a well-characterized mouse Alzheimer's model (CVN-AD) comparing scheduled and dynamic, adaptive or closed-loop approaches to improve metabolism. These experiments will establish the feasibility and parameters to translate into clinical trials of human Alzheimer's disease tACS approaches.

PI_NAMEs: TURNER, DENNIS ALAN (contact)

PROGRAM_OFFICER_NAME: NEWMAN, ELIZABETH

PROJECT_TERMS: abnormally phosphorylated tau;Age;aged;Aging;aging brain;Alzheimer's Disease;Alzheimer's disease model;Animal Disease Models;Animal Model;Animals;appropriate dose;awake;behavior test;Behavioral;behavioral outcome;Biological Markers;Blood capillaries;Blood flow;Blood Vessels;Brain;Cells;Cephalic;Cerebrovascular Circulation;cholinergic;Chronic;circadian;Clinical;Clinical Trials;conventional therapy;cranium;Deep Brain Stimulation;Degenerative Disorder;Dementia;density;Disease;disease model;disease phenotype;Disease Progression;dosage;Dose;efficacious treatment;electric field;Electric Stimulation;Electrodes;Electroencephalography;Etiology;experimental study;Frequencies;functional improvement;gene therapy;Genotype;Glucose;Goals;hemodynamics;Hippocampus;Human;Hyperemia;Impairment;improved;in vivo;Lasers;Link;Measures;Memory;Metabolic;Metabolic Marker;Metabolic stress;Metabolism;metabolomics;Modeling;Motor;Motor Activity;mouse model;Mus;Nerve Degeneration;neurological rehabilitation;neuron loss;Neurons;neuropathology;neuroregulation;neurovascular;neurovascular coupling;Outcome;Outcome Assessment;Penetration;Phenotype;Physiological;Physiology;pre-clinical;predictive marker;Radial;response;Schedule;Senile Plaques;Sensory;Signal Transduction;Skin;spreading depression;Stroke;subcutaneous;Surrogate Markers;Syndrome;tau-1;Testing;Time;Translating;translational approach;translational model;translational potential;voltage

PROJECT_TITLE: Extracranial Brain Stimulation Reduces Metabolic Insufficiency Through Enhanced Cerebral Blood Flow in CVN-AD Alzheimer's Model

STUDY_SECTION: CDIN

STUDY_SECTION_NAME: Chronic Dysfunction and Integrative Neurodegeneration Study Section[CDIN]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Dietary Supplements

ORG_CITY: BOSTON

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: HARVARD MEDICAL SCHOOL

ORG_STATE: MA

PHR: Project Narrative The clinical success of targeting cancer metabolism at curing certain malignancies has increased the growing interest in improving our understanding of how cancer cells rewire metabolism to promote tumorigenesis. The proposed research aims to determine how various cancer cells maintain redox homeostasis to adapt to different nutrient environments and support the elevated biosynthetic demands of uncontrolled proliferation. This research will help uncover novel metabolic vulnerabilities that may lead to the development of more effective and selective cancer treatments.

PI_NAMEs: CHANG, SARAH M (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: Affect;Amino Acids;ATP Synthesis Pathway;Biomass;Caloric Restriction;cancer cell;Cancer cell line;Cancer Patient;cancer therapy;cancer type;Cell Proliferation;Cells;Citrates;Clinical;cofactor;Consumption;cost;Coupled;Development;dietary restriction;Environment;Enzymes;Equilibrium;Fatty Acids;Fermentation;Glucose;Glutamine;Goals;Homeostasis;improved;insight;interest;Lactate Dehydrogenase;Lipids;Malignant Neoplasms;Measures;Mediator;Metabolic;Metabolism;Mitochondria;mouse model;NADH;Natural regeneration;Niacinamide;Non-Essential Amino Acid;novel;Nucleotides;Nutrient;Oxidants;oxidation;Oxidation-Reduction;Oxidative Phosphorylation;Pathway interactions;Physiological;preservation;Process;Production;programs;Proliferating;Protein Biosynthesis;Proteins;Protons;Pyruvate;Reaction;Research;Respiration;response;Role;Serine;success;synergism;Testing;Therapeutic;Tissues;tumor;tumor growth;tumor metabolism;tumorigenesis;uptake

PROJECT_TITLE: Investigating how cancer cells maintain redox homeostasis to support biomass production


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Diabetes;Eye Disease and Disorders of Vision;Genetics;Neurosciences;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Embryonic - Human;Transplantation

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative This project develops pre-clinical approaches for repairing ischemia-damaged retina by employing a new class of ‘naïve’ human induced pluripotent stem cells (N-hiPSC) that can be differentiated to transplantable embryonic ‘naïve’ vascular-pericytic progenitors possessing high epigenetic plasticity. Naïve vascular progenitors (N-VP) derived from diabetic donor cell-derived hiPSC display higher functionality and engraftment capacity in the milieu of the ischemic neural retina, compared to primed vascular progenitors (VP) derived from conventional diabetic hiPSC (DhiPSC). Additionally, more effective reprogramming in naïve DhIPSC (N-DhiPSC) ‘erases’ metabolic epigenetic aberrations harbored in diabetic donor cells to produce ‘pristine’ non- diseased differentiated tissues for regenerative medicine of the diabetic retina.

PI_NAMEs: ZAMBIDIS, ELIAS T. (contact)

PROGRAM_OFFICER_NAME: FORTRESS, ASHLEY

PROJECT_TERMS: Adult;Animal Model;Autologous;Back;Blindness;Blood capillaries;Blood Vessels;cell bank;Cell Line;Cell Reprogramming;Cell Therapy;Cells;Cessation of life;CXCR4 gene;Defect;derepression;Development;Diabetes Mellitus;diabetic;Diabetic Retinopathy;Disease;DNA Methylation;effectiveness evaluation;Embryo;Embryo Transfer;embryonic stem cell;Endothelial Cells;endothelial stem cell;Engraftment;Epiblast;epigenetic memory;Epigenetic Process;epigenome;Eye;Fibroblasts;functional improvement;Functional Regeneration;Future;Gene Expression;Generations;genome integrity;Genome Stability;Histones;Human;human induced pluripotent stem cells;improved;In Vitro;in vivo;in vivo engraftment;in vivo evaluation;Ischemia;Legal patent;Lesion;MCAM gene;Mediating;Memory;Metabolic;migration;Modeling;Molecular;mouse model;Mus;Natural regeneration;neural;Neural Retina;neuron apoptosis;neurovascular injury;novel;PARP inhibition;Pathologic;Pathology;Pathway interactions;Patients;PECAM1 gene;Pericytes;pluripotency;Poly(ADP-ribose) Polymerase Inhibitor;pre-clinical;progenitor;promoter;regeneration function;regeneration potential;Regenerative Medicine;repaired;Reperfusion Injury;Reperfusion Therapy;Reporting;Retina;retina blood vessel structure;retinal damage;Retinal Diseases;retinal ischemia;revascularization;Secondary to;self-renewal;small molecule;stem;stem cell differentiation;stem cell expansion;stem cell self renewal;stem cell survival;stem cell therapy;stem cells;Tankyrase;Therapeutic;therapeutic evaluation;Tissue Differentiation;Tissues;Transplant Recipients;type I diabetic;Vascular Diseases;Vascular Endothelial Cell;vein occlusion;Vision

PROJECT_TITLE: Embryonic vascular stem-progenitors for treatment of ischemic retinopathies

STUDY_SECTION: DPVS

STUDY_SECTION_NAME: Diseases and Pathophysiology of the Visual System Study Section[DPVS]


ADMINISTERING_IC: GM

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: DAVIS

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

ORG_STATE: CA

PHR: PROJECT NARRATIVE The overarching goal of this IMSD Training Program is to increase diversity of the biomedical research workforce via increasing the number of diverse students who complete PhDs in biomedically-related science fields. For this, we propose to enhance and implement comprehensive intervention programs that have research and education activities for graduate students. We anticipate that our carefully developed enrichment activities will produce students who are well-prepared for their dissertation research, who will increase diversity of our PhD life science recipients, and who will successfully advance to the next step of their biomedical research career.

PI_NAMEs: GOMES, ALDRIN V. (contact)

PROGRAM_OFFICER_NAME: STAMM, JOYCE CHIN-CHIN NG

PROJECT_TITLE: IMSD at UC Davis

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - C[TWD-C]


ED_INST_TYPE: UNIVERSITY-WIDE

ORG_CITY: DETROIT

ORG_NAME: WAYNE STATE UNIVERSITY

ORG_STATE: MI

PHR: The Wayne State University (WSU) IMSD T32 program seeks to continue its successful graduate training program in biomedical sciences, and is requesting support for 10 graduate students. Through a structured academic community, additional career development activities, and individualized mentoring, the outstanding, diverse trainees will cultivate highly sought-after skills leading to successful careers in the biomedical sciences.

PI_NAMEs: BRYANT-FRIEDRICH, AMANDA C (contact);CHOW, CHRISTINE S;PERRINE, SHANE ALAN

PROJECT_TERMS: Universities

PROJECT_TITLE: IMSD at Wayne State University


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cardiovascular;Cerebrovascular;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Mental Health;Neurodegenerative;Neurosciences;Post-Traumatic Stress Disorder (PTSD);Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_DEPT: NEUROLOGY

PHR: Public Health Relevance As the number of Asian Americans continues to grow faster than any other racial/ethnic population in the U.S., so too will the number of those with Alzheimer's disease and related dementias; yet very little is known about their risks for cognitive impairment and dementia. This proposal will be the first to study an underserved population of Southeast Asians, Vietnamese Americans, at risk for dementia. Understanding the nuanced roles of early life adversity and trauma as well as sociocontextual diversity in a high disparity group has significant implications for understanding risk and resilience factors in all individuals.

PI_NAMEs: MEYER, OANH L (contact)

PROGRAM_OFFICER_NAME: PERCY-LAURRY, ANTOINETTE LOIS

PROJECT_TERMS: Acculturation;Address;Adult;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;American;Asian Americans;Asian population;Attenuated;Black Populations;California;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;cardiovascular risk factor;Childhood;Chinese;Cognition;Cognitive;Cognitive aging;cognitive function;cohesion;cohort;Communities;community partnership;Data;Dementia;dementia risk;Development;Disease;Disparity population;early life adversity;English Language;Enrollment;ethnic diversity;Ethnic Origin;Ethnic Population;experience;Exposure to;Family Caregiver;Goals;Health;Health Disparities Research;health disparity;High Prevalence;human old age (65+);Immigrant;Immigration;Impaired cognition;Impairment;Individual;innovation;insight;Intervention;Knowledge;Latino Population;Life;Life Cycle Stages;Longitudinal Studies;low socioeconomic status;Mediating;men;Mental Depression;mild cognitive impairment;Modeling;Neighborhoods;Not Hispanic or Latino;novel;Outcome;Pathway interactions;Pattern;physical inactivity;Population;post-traumatic stress;Post-Traumatic Stress Disorders;Prevalence;Prevention;Process;programs;prospective;protective factors;public health relevance;Race;racial diversity;racial minority population;racial population;recruit;Research;resilience;resilience factor;Risk;Risk Factors;Role;San Francisco;sex;sex as a biological variable;smoking prevalence;social culture;social factors;Social support;Socioeconomic Status;southeast Asian;Subgroup;supportive environment;theories;Trauma;trauma exposure;Underserved Population;United States;Universities;Vietnamese;War;Woman;Work

PROJECT_TITLE: Vietnamese Insights into Cognitive Aging Program (VIP)

STUDY_SECTION: HDEP

STUDY_SECTION_NAME: Health Disparities and Equity Promotion Study Section[HDEP]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: AUSTIN

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

ORG_STATE: TX

PHR: Project Narrative The overarching goal of the proposed research is to uncover the role of the primate primary visual cortex (V1) in mediating figure-ground segmentation. We will use multiple experimental techniques to monitor and manipulate neural responses in V1 while animals perform a demanding figure-ground discrimination task with camouflaged targets. These experiments will allow us to test specific hypotheses regarding the way in which V1 interacts with downstream circuits to mediate figure-ground discrimination.

PI_NAMEs: SEIDEMANN, EYAL J (contact)

PROGRAM_OFFICER_NAME: FLANDERS, MARTHA C

PROJECT_TITLE: Linking Neural Population Activity and Visual Perception

STUDY_SECTION: SPC

STUDY_SECTION_NAME: Mechanisms of Sensory, Perceptual, and Cognitive Processes Study Section[SPC]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Biotechnology;Cancer;Colorectal Cancer;Digestive Diseases;Genetics;Rare Diseases

ORG_CITY: EAST LANSING

ORG_DEPT: CHEMISTRY

ORG_NAME: MICHIGAN STATE UNIVERSITY

PHR: Project Narrative We will reveal the proteome dynamics of colorectal cancer cells and tumors at the proteoform level and across various biological conditions. The results will be an unprecedented resource for understanding the colorectal cancer metastasis in a proteoform-specific manner. The data will also help us gain a better understanding of the roles played by mutations and functions of DNA mismatch repair genes in Lynch Syndrome (an inherited form of colorectal cancer) at the proteoform level.

PI_NAMEs: HUMMON, AMANDA B.;LIU, XIAOWEN ;SUN, LIANGLIANG  (contact)

PROGRAM_OFFICER_NAME: AMIN, ANOWARUL

PROJECT_TERMS: Amino Acid Sequence;analytical tool;Biological;Blood capillaries;Brain;Cancer Biology;cancer cell;capillary liquid chromatography;Cell Line;Cells;Cessation of life;colon cancer cell line;Colorectal Cancer;colorectal cancer metastasis;Communities;Consumption;Coupling;Data;Databases;Detection;Diagnosis;Disease;DNA;Electrophoresis;Fractionation;Gene Mutation;gene repair;Genes;Genome;Hereditary Nonpolyposis Colorectal Neoplasms;Human;Immunoprecipitation;Inherited;insight;Lead;Liquid Chromatography;lymph nodes;Malignant Neoplasms;Methods;milligram;Mismatch Repair;Molecular;MSH2 gene;Mutation;nano;Neoplasm Metastasis;neoplasm resource;neoplastic cell;novel;Online Systems;Patients;Persons;Phase;phosphoproteomics;Play;Post-Transcriptional Regulation;Post-Translational Protein Processing;Primary Neoplasm;protein expression;protein function;Proteins;Proteome;Proteomics;Resources;Role;Sampling;SW480;SW620;System;tandem mass spectrometry;Time;Tissues;tool;transcriptome;tumor;Work;Zebrafish

PROJECT_TITLE: Quantitative top-down proteomics of human colorectal cancer cells and tumors

STUDY_SECTION: ISD

STUDY_SECTION_NAME: Instrumentation and Systems Development Study Section[ISD]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Ovarian Cancer;Prevention;Rare Diseases;Women's Health Research

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

ORG_STATE: PA

PHR: Project Narrative Ovarian cancer is the deadliest female cancer in the world, and currently there is no effective preoperative diagnostic biomarker. We have demonstrated that the circulating T cells can be used as indicators of cancer status, and plan to prospectively collect an ovarian cancer patient cohort with matched immunogenomics data and to train a machine learning model to obtain a novel TCR-based biomarker. Successful delivery of our Aims will provide a validated, independent ovarian cancer biomarker with improved diagnostic accuracy.

PI_NAMEs: LEA, JAYANTHI S;LI, BO  (contact);SKATES, STEVEN J

PROGRAM_OFFICER_NAME: PATRIOTIS, CHRISTOS F

PROJECT_TERMS: accurate diagnosis;Adnexal Mass;Affect;Age;antigen-specific T cells;Antigens;Artificial Intelligence;Benign;biobank;Biological Markers;biomarker development;Biometry;Blood;CA-125 Antigen;cancer biomarkers;Cancer Detection;cancer diagnosis;Cancer Etiology;Cancer Patient;Cancerous;Cessation of life;Clinical;Clinical Research;cohort;collaborative trial;Data;Data Set;Death Rate;Detection;detection method;detection sensitivity;Development;Diagnosis;diagnosis standard;Diagnostic;diagnostic accuracy;diagnostic biomarker;diagnostic criteria;Diagnostic Procedure;Diagnostic Specificity;Disease;disease diagnosis;Early Diagnosis;Evaluation;Excision;Female;Future;Goals;Gynecologic Oncology;Histologic;Human;Image;Immune response;Immune system;immunogenicity;Immunogenomics;Immunology;improved;indexing;innovation;Lavage;Lesion;Life;Logistic Regressions;Low Prevalence;machine learning method;machine learning model;machine learning prediction;Malignant - descriptor;Malignant neoplasm of ovary;Malignant Neoplasms;Measures;Methods;Modeling;mortality;multimodality;multiplex assay;Neoplasm Metastasis;noninvasive diagnosis;novel;Operative Surgical Procedures;Ovarian;Ovarian Mass;Ovarian Serous Adenocarcinoma;Ovary;Patients;Pelvis;Performance;Peripheral;Pilot Projects;Planned Pregnancy;preservation;Process;Proliferating;prospective;Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial;Public Domains;recruit;Reporter;Representational Oligonucleotide Microarray Analysis;reproductive;Research Personnel;Risk;Role;Route;Sampling;screening;Screening for Ovarian Cancer;Sensitivity and Specificity;sequencing platform;Serum;Signal Transduction;Skates;software development;specific biomarkers;Specificity;Specimen;Stage at Diagnosis;Symptoms;T cell receptor repertoire sequencing;T-Cell Receptor;T-cell receptor repertoire;T-Lymphocyte;Testing;Tissues;tool;Training;training data;transcriptome sequencing;tumor;Tumor Antigens;Tumor Markers;tumor progression;Ultrasonography;Unnecessary Surgery;Uterus;Vagina;Validation;Woman;young woman

PROJECT_TITLE: Tracking Peripheral T-Cell Repertoire Changes for Preoperative and Early Ovarian Cancer Diagnosis

STUDY_SECTION: CONC

STUDY_SECTION_NAME: Clinical Oncology Study Section[CONC]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Pediatric;Pediatric Cancer;Prevention;Rare Diseases;Skin Cancer

ORG_CITY: NEW YORK

ORG_DEPT: DERMATOLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: NARRATIVE Clinical resistance, tumor recurrence and an unacceptable side-effect profile are the major limitations of currently available targeted therapies for patients with basal cell nevus syndrome (BCNS) (also known as Gorlin-Goltz syndrome) as well as in patients with sporadic BCCs that are surgically inoperable or have metastasized. We will test the hypothesis that dysregulation of the epigenetic regulators BRD7 and BRD9 are drivers of BCC resistance by investigating the mechanisms responsible for these effects and test the preclinical utility of pharmacological BRD9 blockade in overcoming vismodegib resistance, potentially reducing the side-effect profile and improving the therapeutic index of pharmacologic inhibitors of Sonic Hedgehog signaling in these tumors.

PI_NAMEs: BICKERS, DAVID RINSEY (contact);KIM, ARIANNA L

PROGRAM_OFFICER_NAME: HUMBLE, MICHAEL C

PROJECT_TERMS: Ablation;Acceleration;Affect;Alleles;American;ATAC-seq;Automobile Driving;Basal cell carcinoma;Basal Cell Nevus Syndrome;bench to bedside;Binding;Biological Assay;Biological Models;Bromodomain;Bypass;Cell model;Cell Proliferation;Cells;ChIP-seq;Chromatin;chromatin modification;Chromatin Remodeling Factor;Cilia;Clinical;Clinical Trials;combinatorial;Compensation;Complex;constitutive expression;cost;CRISPR/Cas technology;Data;Development;Drug Targeting;Epidermis;Epigenetic Process;epigenomics;Erinaceidae;Exhibits;Fostering;Gene Expression Profile;Genetic;genetic manipulation;genetic signature;genome-wide;genome-wide analysis;Germ-Line Mutation;Growth;Hereditary Disease;Histone Acetylation;Human;Immunodeficient Mouse;immunosuppressed;Implant;improved;In Vitro;in vivo;in vivo evaluation;Individual;inhibitor;insight;keratinocyte;Laboratories;Life;Ligand Binding;loss of function;Malignant Epithelial Cell;Malignant Neoplasms;migration;Modeling;Molecular;mouse model;Mus;Mutation;Neoplasm Metastasis;NOD/SCID mouse;novel;Nucleosomes;Oncogenic;Operative Surgical Procedures;Oral Administration;overexpression;Pathogenesis;Pathway interactions;Patients;Pharmaceutical Preparations;pharmacologic;Pharmacotherapy;Phenotype;PIK3CG gene;pre-clinical;preclinical efficacy;Preclinical Testing;prevent;Prevention;promoter;Proteins;Proteomics;Proto-Oncogenes;reconstitution;Recurrence;Recurrent tumor;Regulation;Repression;Resistance;restoration;Role;Safety;SHH gene;side effect;Signal Transduction;small molecule inhibitor;smoothened signaling pathway;Sucrose;targeted treatment;Testing;Therapeutic Index;transcription factor;transcriptome sequencing;transcriptomics;translational approach;treatment strategy;tumor;Tumor Burden;tumor growth;Tumor Suppressor Proteins;tumorigenic;ultraviolet irradiation

PROJECT_TITLE: Molecular Mechanisms Underlying the Prevention of BCC Resistance

STUDY_SECTION: CPSS

STUDY_SECTION_NAME: Cancer Prevention Study Section[CPSS]


NIH_SPENDING_CATS: Dietary Supplements;Nutrition

ORG_CITY: COLLEGE STATION

ORG_NAME: TEXAS A&M UNIVERSITY

PHR: Biotin is an essential vitamin in animal and human nutrition. Understanding its catabolism adds important fundamental knowledge to the metabolism of this vitamin and facilitates the evaluation of the role of gut microbiome mediated biotin catabolism in human nutrition.

PI_NAMEs: BEGLEY, TADHG P. (contact)

PROGRAM_OFFICER_NAME: BARSKI, OLEG

PROJECT_TITLE: Biotin catabolism: an unwritten chapter in the metabolism of an essential vitamin

STUDY_SECTION: SBCB

STUDY_SECTION_NAME: Synthetic and Biological Chemistry B Study Section[SBCB]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Clinical Research;Comparative Effectiveness Research;Emergency Care;Health Services;Neurosciences;Patient Safety;Telehealth

ORG_CITY: PITTSBURGH

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Rigorous clinical trials are necessary to improve acute treatment for time-sensitive and life-threatening conditions. The unexpected nature of emergency conditions requires special preparation and skill to recruit and protect participants in clinical trials. Emergency care spans multiple locations including ambulances, emergency departments, intensive care units, and even homes. An experienced research team will implement pragmatic and successful strategies to accomplish enrollment under all these conditions and in all these settings at multiple locations as part of a national emergency care research network.

PI_NAMEs: CALLAWAY, CLIFTON W. (contact)

PROGRAM_OFFICER_NAME: SCOTT, GRETCHEN CARLYLE

PROJECT_TERMS: Academic Medical Centers;Acceleration;Accident and Emergency department;Acute;Address;Adoption;Ambulances;Ancillary Study;career;Catheterization;Clinical;clinical development;Clinical Trials;Clinical Trials Network;Communities;community engagement;Consent;Coronary;COVID-19 pandemic;Data;Department of Defense;Development;Distress;Electronic Health Record;Emergency Care;Emergency medical service;Emergency Medicine;Emergency research;emergency settings;Emergency Situation;Emergency treatment;Enrollment;Ensure;Environment;experience;Fellowship;Fostering;Funding;Future;Geography;Health Technology;Home;Hospitals;improved;Informed Consent;Infrastructure;innovation;Intensive Care Units;Lead;Leadership;Learning;Life;Location;member;Mentors;Methods;mHealth;Nature;novel;outreach;Participant;participant enrollment;Patient Recruitments;Patients;Phase;Preparation;Procedures;Process;Protocols documentation;Publishing;recruit;remote consent;Research;Research Personnel;Rural;Scientific Advances and Accomplishments;screening;Secure;Site;skills;Structure;success;Teacher Professional Development;telepresence;Text Messaging;Time;Training;treatment trial;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Strategies to Innovate EmeRgENcy Care Clinical trials Network (SIREN) Network - Pittsburgh


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: JACKSON

ORG_NAME: UNIVERSITY OF MISSISSIPPI MED CTR

ORG_STATE: MS

PHR: Cardiovascular inflammation promotes Heart failure (HF) development, and lung inflammation promotes the transition from left HF to right HF and death. By using experimental studies and a powerful single cell genomic profiling of immune cells after HF, we have identified PD1 (an important target for cancer therapy) and several related genes as potential important targets to regulate cardiac and lung inflammation resolution during HF. We will investigate the role and mechanism of PD1 and these related targets in HF development and HF progression.

PI_NAMEs: CHEN, YINGJIE  (contact)

PROGRAM_OFFICER_NAME: SHI, YANG

PROJECT_TERMS: adaptive immune response;Antibodies;aorta constriction;Attenuated;Bar Codes;Bioinformatics;Blocking Antibodies;cancer therapy;Cardiac;Cardiotoxicity;Cardiovascular Diseases;Cardiovascular system;CD8-Positive T-Lymphocytes;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Cessation of life;cytokine release syndrome;Development;experimental study;Failure;Genes;genomic profiling;heart cell;Heart failure;IL17 gene;IL1R1 gene;Immune;Immune response;Infiltration;Inflammation;innovation;interest;Investigation;Knockout Mice;Label;Left;Lung;Macrophage;Mediating;Membrane Proteins;Metabolic Pathway;Mus;Myocarditis;Pathway interactions;Patients;Play;Production;programmed cell death protein 1;Proteins;Pulmonary Hypertension;Pulmonary Inflammation;Resolution;right ventricular failure;Role;sham surgery;Signal Transduction;single cell genomics;Stress;T cell infiltration;T-Cell Activation;T-Lymphocyte;T-Lymphocyte Subsets;targeted cancer therapy;Testing;Toxic effect;Vascular Endothelial Cell

PROJECT_TITLE: Mechanism of  PD1 on cardiac inflammation resolution  during heart failure development

STUDY_SECTION: MPPA

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology A Study Section [MPPA]


NIH_SPENDING_CATS: Burden of Illness;Cancer;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Hepatitis;Liver Cancer;Liver Disease;Prevention;Rare Diseases;Social Determinants of Health

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: Project Narrative Each year 700,000 people die from hepatocellular carcinoma and nearly all of these deaths are preventable with appropriate screening and treatment. Migrants to the United States have increased risk due to unrecognized viral hepatitis infections but have poorer access to screening and treatment, resulting in disproportionally high rates of cancer and death. This proposal seeks to reduce preventable cancer deaths in migrants by improving our understanding of who should be screened and how they should be treated, this knowledge will have a direct impact on health policy and patient care, helping people to live longer, healthier lives.

PI_NAMEs: VALLES, KENNETH ANDREW (contact)

PROGRAM_OFFICER_NAME: PURI, ANU

PROJECT_TERMS: Affect;Age;age group;American;burden of illness;Cancer Etiology;Cessation of life;Characteristics;Chronic;Chronic viral hepatitis;Communities;comorbidity;Cost-Benefit Analysis;Country;Data;data registry;Data Set;demographics;Detection;Development;Disease;disease disparity;disease model;Disease Progression;disorder risk;end stage liver disease;Ensure;Epidemic;epidemiologic data;Europe;European;European Union;experience;Failure;Future;Generations;Goals;Guidelines;Health;health data;health management;Health Policy;Hepatitis;Hepatitis B Infection;Hepatitis C virus;HIV;human migration;Immigrant;Immigration;improved;Incidence;Individual;Infection;innovation;Knowledge;Length;Liver Cirrhosis;liver inflammation;Long-Term Care;low income country;Malaria;Malignant neoplasm of liver;Malignant Neoplasms;Measures;Mental disorders;Migrant;migration;Modeling;Modification;Morbidity - disease rate;mortality;Outcome;Patient Care;Patients;Persons;Policies;Policy Maker;poor health outcome;Population;Population Statistics;Prevalence;preventable death;Prevention;Primary carcinoma of the liver cells;Process;programs;Records;Research;Risk;risk stratification;routine screening;screening;screening policy;Severities;Sweden;Testing;Treatment Cost;Tuberculosis;United States;Vaccination;Viral hepatitis;World Health Organization

PROJECT_TITLE: Reducing the Burden of Hepatocellular Carcinoma Among Migrant Populations: Improving prevention and outcomes through disease modeling

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F18-G(20)]


ORG_CITY: Aurora

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF COLORADO DENVER

PHR: PROJECT NARRATIVE Joint bleeding in hemophilia leads to arthropathy and is not fully prevented by standard prophylactic treatments. Joint and muscle bleeding likely cause changes in movement strategies and lower limb biomechanics, which we hypothesize leads to subsequent increased risk of lower extremity bleeding. This proposal seeks to better understand the biomechanics of joint and muscle bleeding, with a goal of quantifying bleeding risk at any given time in future studies.

PI_NAMEs: WARREN, BETH BOULDEN (contact)

PROGRAM_OFFICER_NAME: FRANK, DANIEL J

PROJECT_TERMS: Acceleration;Ankle;arthropathies;Biomechanics;Biomedical Engineering;Blood;Blood coagulation;Blood Coagulation Disorders;Blood Coagulation Factor;career;career development;Clinical Research;cohort;Collection;Colorado;cost;Data;Data Analyses;Dose;Dyskinetic syndrome;empowerment;Event;experience;F8 gene;Factor IX;Factor VIII;Faculty;Financial Hardship;Frequencies;Future;Gills;Goals;Health;Hematology;Hemophilia A;Hemophilic Arthritis;Hemorrhage;Hemostatic Agents;improved;Infrastructure;Inherited;Injections;Interruption;Intravenous;intravenous administration;joint biomechanics;joint injury;joint loading;Joints;Knee;Knowledge;Lead;Leg;Life;Linear Regressions;Lower Extremity;Measurement;Measures;medication administration;member;Mental Health;Mentored Patient-Oriented Research Career Development Award;Mentors;Methods;Modeling;Motion;Movement;movement analysis;Muscle;novel strategies;obesity prevention;Outcome;Outcome Measure;Participant;patient oriented;Pattern;Persons;Pharmaceutical Preparations;Physical activity;Physical therapy;predictive modeling;prevent;Prevention;prophylactic;Prophylactic treatment;prospective;Prospective cohort;Regimen;Regression Analysis;Research;research and development;Research Personnel;Risk;Risk Factors;Rotation;Running;Science;Scientist;Secure;Severities;signal processing;Signal Transduction;skills;smartphone application;Social Functioning;Statistical Models;Stress;Techniques;Technology;Testing;Therapeutic Intervention;Thrombosis;Time;Tissues;tool;Training;Universities;Variant;Walking;wearable device;Weight

PROJECT_TITLE: Exploring the Biomechanics of Joint Bleeding in Persons with Hemophilia to Better

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(OA)]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Emergency Care;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Hematology;Infectious Diseases;Neurosciences;Physical Injury - Accidents and Adverse Effects;Rural Health;Social Determinants of Health

ORG_CITY: RICHMOND

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: The CORE-EM Alliance (Coalition for Research in Emergency Medicine) brings to SIREN six, highly experienced research infrastructures, each with their own spokes, partnering as an innovative, single, super-hub within the SIREN network. The goal of CORE-EM is to provide rapid implementation and high-quality performance in large pragmatic clinical trials to study acute conditions including neurologic, cardiovascular, respiratory, hematologic, infectious disease, and trauma-related emergencies. CORE-EM is committed to conducting rigorous trials, training the next generation of physician scientists, and providing outstanding clinical care to diverse populations of patients through excellence in research, discovery, and implementation science.

PI_NAMEs: KARFUNKLE, BENJAMIN L;MERCK, LISA H (contact);MOSIER, JARROD ;PAPA, LINDA ;SELKER, HARRY P.;WRIGHT, DAVID W

PROJECT_TERMS: Accident and Emergency department;Acute;acute care;acute coronary syndrome;American;Arizona;Attention;Back;bilingualism;Cardiology;Cardiovascular system;career development;Caring;Catchment Area;Clinical;clinical care;Clinical Research;clinical trial implementation;clinical trial participant;Clinical Trials;Collaborations;college;Communicable Diseases;Conduct Clinical Trials;COVID-19;Critical Care;demographics;design;Development;Disease;Education;Emergency Care;Emergency Department patient;Emergency Department Physician;Emergency Medicine;Emergency research;Emergency Situation;Enrollment;Ensure;ethnic diversity;experience;faculty mentor;Florida;Foundations;Funding;Geographic Locations;Glucose;Goals;Heart Arrest;Hematology;Hospital Departments;Hospitals;implementation science;Individual;Infrastructure;Injury;innovation;Insulin;Intensive Care;Intravenous;Investments;Junior Physician;Leadership;Maine;Medical center;medical specialties;Medicine;member;Morbidity - disease rate;mortality;multidisciplinary;Multiple Trauma;National Center for Advancing Translational Sciences;National Institute of Neurological Disorders and Stroke;Neurologic;neurosurgery;next generation;novel therapeutic intervention;Nurses;Operating Rooms;Participant;participant enrollment;Pathology;patient population;Patients;Performance;Persons;Physicians;Population;Population Heterogeneity;Potassium;Pragmatic clinical trial;Principal Investigator;Productivity;programs;Protocols documentation;Provider;racial diversity;Readiness;Recording of previous events;recruit;Rehabilitation therapy;Research;Research Infrastructure;Research Personnel;Resources;respiratory;Resuscitation;Rhode Island;Rural;Rural Community;rural setting;Scientist;Services;Site;Societies;Spinal cord injury;Structure;Texas;Training;Trauma;trauma centers;Underrepresented Minority;United States Agency for Healthcare Research and Quality;United States Department of Veterans Affairs;United States National Institutes of Health;Universities;Urban Community;urban setting;Virginia;Work

PROJECT_TITLE: SIREN CORE-EM HUB ALLIANCE


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: SEATTLE

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

ORG_STATE: WA

PHR: Project Narrative Using airway epithelial cells from clinically well characterized asthmatic children, we will investigate the regulation of epithelial interferon responses to viral infection and the impacts of excessive or deficient epithelial interferon responses on incident viral triggered asthma exacerbation risk and lung function over time. The studies conducted in my research program, and unique resource of primary airway epithelial cells from clinically well characterized asthmatic children, provide an exceptional training environment for young investigators dedicated to a career in mechanistic patient-oriented research to learn translational research techniques to investigate the role of the airway epithelium in pediatric lung diseases and viral infection.

PI_NAMEs: DEBLEY, JASON S (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Adrenal Cortex Hormones;Air;airway epithelium;airway remodeling;Asthma;asthma exacerbation;asthmatic;asthmatic airway;asthmatic patient;Biological Models;Biological Products;career;Cell Culture Techniques;Cell Line;Cell model;Cells;Child;Childhood;Childhood Asthma;Clinical;Code;cohort;cost;cytokine;Dedications;Emergency department visit;Environment;Epithelial Cells;Epithelium;experimental study;Fibroblasts;Frequencies;functional decline;Gene Expression;Genes;Genetic Polymorphism;Goals;Heterogeneity;Hospitalization;Human;IFIH1;Incidence;Infection;Inflammation;Inhalation;Innate Immune Response;Interferons;Learning;Liquid substance;loss of function;Lung;Lung Diseases;Modeling;Morbidity - disease rate;Myofibroblast;Natural History;Nose;Pathogenesis;patient oriented;patient oriented research;Patients;Phenotype;Play;prevent;programs;Proliferating;prospective;pulmonary function;pulmonary function decline;Regulation;Reporting;Research;Research Personnel;Research Technics;Resources;Respiratory Syncytial Virus Infections;Respiratory Tract Infections;response;Rhinovirus;Rhinovirus infection;Risk;Role;Schools;sensor;Series;Signal Transduction Pathway;Stromal Cells;Subgroup;Techniques;Testing;Time;Training;Translational Research;translational study;Viral;Virus;Virus Diseases;Virus Replication

PROJECT_TITLE: Clinical Impacts of Heterogeneous Interferon Responses to Viral Infection by Asthmatic Airway Epithelium

STUDY_SECTION: AITC

STUDY_SECTION_NAME: Allergy, Immunology, and Transplantation Research Committee[AITC]


NIH_SPENDING_CATS: Breastfeeding, Lactation and Breast Milk;Clinical Research;Digestive Diseases;Food Allergies;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: NARRATIVE Eosinophilic esophagitis (EoE), a recently recognized disease with a rapidly increasing incidence, prevalence, and health care burden, is characterized by the abnormal presence of eosinophils in the esophageal lining, leading to failure to thrive, abdominal pain, vomiting, and heartburn in children, and progressing to esophageal stenosis and food impaction in adults. The goals of this project are to identify early life factors that increase risk for EoE by measuring environmental exposures in deciduous (“baby”) teeth, and to determine the mechanisms by which these early life factors may act. The proposed study will impact patients with EoE not only by increasing the knowledge of EoE disease pathogenesis, but by potentially identifying opportunities for disease prevention which could lead to the development of new treatment options.

PI_NAMEs: DELLON, EVAN SAMUEL (contact);JENSEN, ELIZABETH T

PROGRAM_OFFICER_NAME: JOUBERT, BONNIE

PROJECT_TERMS: 3-Dimensional;Abdominal Pain;Address;Adolescent;Adult;Allergens;Amoxicillin;Antibiotics;Architecture;archived data;Azithromycin;Barium;Biological Assay;Biological Markers;Biology;Breast Feeding;Calpain;Caring;Case/Control Studies;Cephalexin;Child;Childhood;Clinical;Collaborations;Data;Deposition;design;Development;Diagnosis;Disease;disorder prevention;Early identification;early life exposure;Environmental Exposure;Environmental Risk Factor;eosinophil;Eosinophilic Esophagitis;Epidemiology;epidemiology study;Epithelium;Esophageal Dysphagia;Esophageal mucous membrane;Esophageal Stenosis;Esophagus;Etiology;Exogenous Factors;Exposure to;Failure to Thrive;fetal;Food;Frustration;Future;gastrointestinal;gene environment interaction;Genetic Determinism;Genetic Predisposition to Disease;Genetic Risk;Genotype;Goals;healthcare burden;Heartburn;Human;Human Milk;Immune;Impairment;Incidence;Individual;individual patient;Infiltration;innovation;interest;Investigation;Knowledge;Laboratories;Life;Link;Measurement;Measures;Mediating;Methodology;Methods;microbial products;microbiome;Modeling;Molecular;Morbidity - disease rate;multidisciplinary;new therapeutic target;novel;Pathogenesis;Patients;Peptide Hydrolases;Predisposition;Prevalence;Research;Research Design;Risk;Risk Factors;risk variant;Sampling;Science;Susceptibility Gene;Techniques;TLR2 gene;Toll-like receptors;Tooth structure;toxicant;United States;Vomiting

PROJECT_TITLE: Epidemiologic identification and mechanistic investigation of early life environmental risk factors for eosinophilic esophagitis

STUDY_SECTION: KNOD

STUDY_SECTION_NAME: Kidney, Nutrition, Obesity and Diabetes Study Section[KNOD]


NIH_SPENDING_CATS: Congenital Structural Anomalies;Eye Disease and Disorders of Vision;Pediatric

ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: Project Narrative Our research aims at understanding the development and aging of the eye lens. We believe that such an understanding will lead to an ability to delay of possibly eliminate cataract surgery and its possible complications. Delaying cataract surgery by even a few years or reducing its most common complications could reduce health care costs by a very significant amount.

PI_NAMEs: TOBIAS, DOUGLAS J (contact)

PROGRAM_OFFICER_NAME: ARAJ, HOUMAM H

PROJECT_TERMS: Address;Adhesions;Adhesives;Adverse effects;Aging;Amino Acids;Animals;Area;Binding;Biological Assay;Biophysics;Blindness;Calmodulin;Cataract;Cataract Extraction;Cell Adhesion;Cell Volumes;Cellular Morphology;Computer Simulation;Coupled;Coupling;CRISPR/Cas technology;Crystalline Lens;Data;Defect;Development;Exhibits;experimental study;extracellular;Family;fiber cell;filensin;Financial Hardship;Fishes;Future;Gap Junctions;Gene Combinations;Gene Modified;Genes;Genetic;Genetic Engineering;Health Care Costs;Health system;improved;in silico;In Vitro;in vivo;innovation;interdisciplinary approach;Investigation;Killifishes;knock-down;Knock-out;Lead;lens;lens cortex;Lens development;Lens Fiber;lens transparency;Life;Location;Maintenance;Measurement;Measures;Medical;Membrane Proteins;Methodology;MIP gene;Modeling;Modification;Molecular;molecular dynamics;mutant;Mutation;Oocytes;Operative Surgical Procedures;Optics;Permeability;Phosphoric Monoester Hydrolases;Physiology;Play;Post-Translational Protein Processing;prevent;Property;Proteins;Protons;Refractive Indices;regional difference;Regulation;Research;Role;Structure;Surgical sutures;Swelling;Techniques;Testing;therapeutic development;trend;Variant;Water;water channel;Water Movements;Work;Xenopus oocyte;Zebrafish

PROJECT_TITLE: Structure-Function Studies of Aquaporin 0 in Lens Development and Physiology

STUDY_SECTION: BVS

STUDY_SECTION_NAME: Biology of the Visual System Study Section[BVS]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Digestive Diseases;Pancreatic Cancer;Rare Diseases

ORG_CITY: LA JOLLA

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE Pancreatic cancer (PC) is a highly lethal malignancy with surgical resection as the most effective curative option. Limited sensitivities of pre-operative imaging modalities, inconspicuous lesion/margin detection under white light, and limited efficacy of surgical Laparoscopy to visualize small lesions contribute to incomplete resections, high local recurrence rates, and poor outcomes. We propose to develop and evaluate MUC4-targeted near-infrared fluorescence imaging probes to facilitate fluorescence-guided surgical navigation for improved surgical resection of PC and its pre-malignant precursor lesions.

PI_NAMEs: BATRA, SURINDER K.;BOUVET, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: DARDZINSKI, BERNARD JOSEPH

PROJECT_TERMS: Adenocarcinoma;advanced disease;American;Animal Model;antibody conjugate;Autopsy;Biodistribution;Cancer Detection;Cancer Etiology;cancer invasiveness;Cell Line;Cessation of life;Chemotherapy and/or radiation;Clinical;clinical efficacy;Consensus;Cues;Curative Surgery;Cystic Lesion;Detection;Development;Diagnostic;differential expression;Disease Progression;Drug Kinetics;Dyes;efficacy evaluation;Epitopes;ex vivo imaging;Excision;Exhibits;Fine needle aspiration biopsy;Fluorescence;fluorescence imaging;fluorescence-guided surgery;Fluorescent Dyes;Fluorescent Probes;Genetically Engineered Mouse;Goals;high risk;Human;Image;image guided;Image-Guided Surgery;imaging modality;imaging probe;improved;in vivo;inducible gene expression;KRASG12D;Label;Laboratories;Laparoscopy;Lesion;Light;Malignant - descriptor;Malignant neoplasm of pancreas;Malignant Neoplasms;Membrane;Modality;Modeling;molecular imaging;Molecular Weight;Monoclonal Antibodies;mouse model;Mucins;Nature;Near-Infrared Fluorescence Imaging Probe;Neoplasm Metastasis;Oncogenic;Operative Surgical Procedures;Optics;Outcome;overexpression;Pancreas;Pancreatic Adenocarcinoma;Pancreatic Intraepithelial Neoplasia;pancreatic neoplasm;Pathology;Patients;Performance;Phase I Clinical Trials;pre-clinical assessment;Pre-Clinical Model;preclinical efficacy;preclinical evaluation;preclinical safety;preclinical study;premalignant;programs;Progressive Disease;Recurrence;Resistance;Risk;Role;Safety;Sampling;Sensitivity and Specificity;Signal Transduction;Societies;Specificity;Specimen;Staging;subcutaneous;success;Surgical Oncology;Survival Rate;Tactile;Tandem Repeat Sequences;targeted imaging;Testing;Time;Tissues;tool;Toxic effect;Transgenes;Transgenic Organisms;tumor;tumor progression;Tumor Tissue;Visualization;Xenograft Model

PROJECT_TITLE: Molecular Imaging Probe(s) for Optical Surgical Navigation of Pancreatic Cancer

STUDY_SECTION: IGIS

STUDY_SECTION_NAME: Imaging Guided Interventions and Surgery Study Section[IGIS]


ORG_CITY: WORCESTER

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: PROJECT NARRATIVE The intestinal microbiome harbors a community of commensal and pathogenic bacteria, yet the mechanisms of pathogen detection by the intestinal epithelium remain poorly understood. Proper detection of pathogens promotes human intestinal health. This proposal will define a new mechanism of pathogen sensing by intestinal cells in a model organism.

PI_NAMEs: TSE, SAMANTHA  (contact)

PROGRAM_OFFICER_NAME: DENSMORE, CHRISTINE L

PROJECT_TERMS: Anti-Infective Agents;Anti-Inflammatory Agents;Bacteria;Bacterial Toxins;Bone Marrow Transplantation;Caenorhabditis elegans;Cell Communication;Cells;Cessation of life;chemotherapy;commensal bacteria;commensal microbes;Data;Detection;Development;Embryonic Development;enteric infection;enteric pathogen;Epithelial Cells;Family;Genes;Genetic Transcription;gut colonization;gut inflammation;gut microbiome;Health;HNF4A gene;Homologous Gene;Hormone Receptor;Hospitalization;Human;human pathogen;Immune;immune activation;Immune response;Immunocompromised Host;immunoregulation;Infection;Inflammation;Inflammatory;Inflammatory Bowel Diseases;Inflammatory Response;Innate Immune Response;insight;interest;intestinal epithelium;Intestines;Ligands;Metabolism;model organism;Modeling;Molecular;Monitor;mutant;Natural Immunity;novel;Nuclear Hormone Receptors;Nuclear Receptors;Organism;Oxidation-Reduction;pathogen;Pathogen detection;Pathogenesis;pathogenic bacteria;pathogenic microbe;Pathogenicity;Patients;Pattern Recognition;Pattern recognition receptor;Phenazines;Physiological;Positioning Attribute;Process;programs;Protein Isoforms;Pseudomonas aeruginosa;Pseudomonas aeruginosa infection;Research;resident commensals;response;Role;Sepsis;Septicemia;Testing;Therapeutic;therapeutic target;Toxin;transcription factor;Transcriptional Activation;Transplant Recipients;Virulence

PROJECT_TITLE: Detection of intestinal pathogens through host surveillance of bacterial toxins


ORG_CITY: TUCSON

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: Our long-term goal is that our UA biomedical sciences Ph.D. students contribute to diversifying the national workforce and become leaders in our institution, in our state and in our nation. Our vision is that our strengths- based guidance and mentoring enable our students to be part of a community of diverse and excellent scholars that mentor and support each other as they move through the steps of their career pathways. This IMSD proposal supports twelve students from groups underrepresented in the biomedical sciences in the first year of their graduate programs, and the IMSD program continues to mentor and guide these students until they complete their PhDs.

PI_NAMEs: TAX, FRANS E (contact)

PROJECT_TITLE: University of Arizona's Initiative for Maximizing Student Development (IMSD)


NIH_SPENDING_CATS: Breast Cancer;Cancer;Women's Health Research

ORG_CITY: ALBANY

ORG_NAME: ALBANY MEDICAL COLLEGE

PHR: NARRATIVE To advance our understanding of breast cancer on a subcellular level, we will investigate the role of early endosomal function, morphology and mitochondria interaction on the regulation of receptor-mediated signaling pathways and iron homeostasis. Early endosomes act as a literal “fork in the road” for receptors, as both the endocytic recycling and lysosomal pathways are initiated from this dynamic organelle. Early endosomes play a crucial role in the transport of metabolic nutrients, such as iron, as well as in receptor signaling via epithelial growth factor receptor. Significantly, cancer cells exhibit an enhanced dependence on iron for growth and are more susceptible to iron depletion than their normal counterparts. Since cancer cell 3D growth was shown to alter organelle morphology and better mimic in vivo tumor characteristics, the analysis of the morphology and function of organelles and inter-organelle interactions in 3D tumor systems is the new frontier of cancer cell biology. Thus, breast cancer cells grown as 3D tumor systems in vitro will be used to elucidate the complex relationship between signaling and iron metabolism that takes place in the early endosomes, and cancer progression.

PI_NAMEs: BARROSO, MARGARIDA  (contact)

PROGRAM_OFFICER_NAME: CERO, CHERYL

PROJECT_TERMS: 3-Dimensional;Address;Affect;Biochemical;Biological;Breast Cancer Cell;breast cancer progression;Bypass;cancer cell;Cancer cell line;cancer diagnosis;cancer therapy;Cell Culture Techniques;Cell membrane;Cell Physiology;Cell Proliferation;Cells;Cellular biology;Characteristics;comparative;Complex;Cytosol;Dependence;Development;Early Endosome;EGF gene;Endosomes;Epithelium;Exhibits;Foundations;Freezing;frontier;Growth;Growth Factor Receptors;Guanosine Triphosphate Phosphohydrolases;Homeostasis;Human;In Vitro;in vivo;Iron;iron metabolism;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Neoplasms;MCF10A cells;Mediating;Metabolic;Microscopy;migration;Mitochondria;mitochondrial membrane;Molecular;Morphology;Nature;new therapeutic target;novel;Nutrient;Organelles;overexpression;Oxygen;Pathway interactions;Phosphotransferases;Play;Population;Predisposition;Process;Property;receptor;Receptor Activation;Receptor Signaling;receptor-mediated signaling;Recycling;Regulation;Research Proposals;Role;sensor;Shapes;Signal Pathway;Signal Transduction;Site;System;Testing;TFRC gene;Three-Dimensional Imaging;Tissues;tool;trafficking;tumor;Tumor Biology;tumor progression;Tumor Tissue;Work

PROJECT_TITLE: Endosome-mitochondria interactions in breast cancer cells

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-H(55)R]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cannabinoid Research;Drug Abuse (NIDA only);Endocannabinoid System Research;Neurosciences;Substance Misuse;Women's Health Research

ORG_CITY: BALTIMORE

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PHR: Project Narrative Addiction is a chronically relapsing neurobiological disorder that impacts both men and women but there are sex-specific patterns of drug use and relapse vulnerabilities in clinical and preclinical populations. Recent research suggests that individual differences before drug experience predict addiction vulnerability. To better understand the influence of sex on relapse vulnerability phenotypes, I propose to investigate sex differences in brain circuitry that is critical for sex- and phenotype-specific behavioral flexibility before drug experience.

PI_NAMEs: STAPF, CATHERINE A. (contact)

PROGRAM_OFFICER_NAME: BABECKI, BETH

PROJECT_TERMS: addiction;Affect;Automobile Driving;Behavior;Behavioral;Brain;brain circuitry;Cells;Chronic;Clinical;Clinical Research;CNR1 gene;cocaine craving;cocaine relapse;cocaine use;Corpus striatum structure;craving;cue reactivity;Cue-induced relapse;Cues;Data;Development;Disease;Dorsal;Drug Exposure;drug of abuse;drug relapse;Drug usage;Electrophysiology (science);endocannabinoid signaling;Endocannabinoids;Equilibrium;experience;experimental study;Female;flexibility;Food;gamma-Aminobutyric Acid;Genetic;Genetic Transcription;Glutamates;Goals;Human;Impairment;Individual;Individual Differences;Interneurons;male;Mediating;men;Messenger RNA;Modeling;Molecular;Motivation;mRNA Expression;Neurobiology;Neurons;neurotransmitter release;optogenetics;Outcome;patch clamp;Pathway interactions;Pattern;Pharmaceutical Preparations;Pharmacology;Phenotype;Physiological;Population;pre-clinical;preclinical study;presynaptic;prevent;Probability;Rattus;Receptor Activation;Receptor Signaling;Regulation;Relapse;Reporting;Research;Rewards;Rodent;sex;Sex Differences;Slice;Substance Use Disorder;Synapses;Testing;transmission process;Vulnerable Populations;Woman

PROJECT_TITLE: Sex Differences in Endocannabinoid Regulation of Behavioral Flexibility


NIH_SPENDING_CATS: Cancer;Clinical Research;Colorectal Cancer;Complementary and Integrative Health;Dietary Supplements;Digestive Diseases;Genetics;Nutrition;Prevention

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PROJECT NARRATIVE Colorectal cancer is the third most common cancer in the United States and modifiable risk reduction strategies are needed. This study will be the first Mendelian randomization study to investigate the potential causal relation between long-chain polyunsaturated fatty acids (PUFAs) and risk of colorectal tumors (cancer and adenomas) in Caucasians. The knowledge gained from this study may help to identify prevention strategies for colorectal cancer.

PI_NAMEs: KHANKARI, NIKHIL KISHOR (contact)

PROGRAM_OFFICER_NAME: MECHANIC, LEAH E

PROJECT_TERMS: 11q12;6p24;Address;adenoma;Affect;Algorithms;Animals;Anti-Inflammatory Agents;Arachidonic Acids;Area;Aspirin;Award;Binding;biobank;Biological Markers;Blood;Blood specimen;cancer risk;carcinogenesis;Caucasians;Colorectal;Colorectal Adenoma;Colorectal Cancer;colorectal cancer prevention;colorectal cancer risk;Colorectal Neoplasms;Colorectal Polyp;Computerized Medical Record;cost efficient;Coxibs;cyclooxygenase 2;Data;Diagnosis;dietary;Dinoprostone;DNA;Drug usage;Eicosanoid Production;Eicosanoids;Enzymes;epidemiology study;Erythrocytes;Etiology;fatty acid metabolism;Fish Oils;Genetic;genetic epidemiology;genetic variant;Genome;genome wide association study;Genotype;Goals;improved;In Vitro;Individual;Inflammatory;inflammatory marker;innovation;instrument;Intake;K-Series Research Career Programs;Knowledge;Malignant Neoplasms;Maps;Measures;Mediation;Mediator;Mendelian randomization;Metabolism;modifiable risk;Molecular Epidemiology;Molecular Epidemiology of Cancer;Non-Steroidal Anti-Inflammatory Agents;nutrition;Observational epidemiology;Observational Study;Omega-3 Fatty Acids;Omega-6 Fatty Acids;Pathway interactions;Patients;Pharmaceutical Preparations;Phenotype;PIK3CA gene;Plasma;polygenic risk score;Polyunsaturated Fatty Acids;Prevention strategy;Production;programs;Prostaglandin Inhibition;Prostaglandin Production;Research;Research Training;Resources;Risk;Risk Reduction;Stratification;Structural Models;Study Subject;Supplementation;Tennessee;Tissue Sample;Training;tumor;Tumor Markers;Tumor Tissue;United States;Universities;urinary;Variant;WFDC2 gene

PROJECT_TITLE: Polyunsaturated fatty acids and colorectal tumor risk: a molecular and genetic epidemiology study

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Transition to Independence Study Section (I)[NCI-I]


NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: EUGENE

ORG_NAME: UNIVERSITY OF OREGON

ORG_STATE: OR

PHR: PROJECT NARRATIVE There is a spectacular amount of genetic and phenotypic diversity on Earth, but a clear mapping between genotype and phenotype often remains elusive, inhibiting our understanding of complex traits and diseases. Indeed, phenotypic variation is not sufficiently explained by genetic variation, and genetic variation is itself present in apparent excess. This project aims to test the premise that epigenetic variation is a key causal factor for explaining this abundance of both phenotypic and genetic variation, by empirically assessing how epigenetic variation may explain differences among genetically identical individuals and theoretically how heritable epigenetic variation may influence the maintenance of genetic variation.

PI_NAMEs: WEBSTER, AMY KATHERINE (contact)

PROGRAM_OFFICER_NAME: XU, JIANHUA

PROJECT_TERMS: Address;Adult;Affect;Alleles;ATAC-seq;Automobile Driving;Back;Biological Assay;Caenorhabditis elegans;Chromatin;Complex;Development;Diploidy;Disease;DNA Sequence Alteration;dynamic system;egg;emerging adult;Engineering;Environmental Risk Factor;Epigenetic Process;epigenetic regulation;epigenetic variation;epigenomics;Etiology;Exhibits;experience;experimental study;fitness;Gene Expression;Gene Expression Profile;gene expression variation;gene network;Generations;Genes;Genetic;Genetic Models;Genetic Transcription;genetic variant;Genetic Variation;Genotype;Goals;Heritability;Human;Individual;Individual Differences;insight;Left;Life;Life Experience;Maintenance;Maps;Maternal Age;Measures;Mediating;Modeling;Molecular;Mutation;Nature;Nematoda;non-genetic;Organism;Outcome;Output;Phenotype;Planet Earth;Play;Population;Population Genetics;Probability;Regulation;reproductive;Resolution;Role;Shapes;System;Temperature;Testing;Theoretical model;Time;Traction;trait;transcriptome sequencing;Twin Studies;Variant;Work

PROJECT_TITLE: Epigenetic regulation underlying phenotypic variation and driving evolutionary trajectories

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F08-M(20)L]


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Data Science;Epilepsy;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: PROJECT NARRATIVE The goal of this project is to characterize a novel biomarker of seizures using advanced computer algorithms that monitor brainwaves in real time. These biomarkers, known as High Frequency Oscillations, have been recognized for some time but their research has been restricted to very short datasets within a handful of centers worldwide. This project will use Big Data tools to help translate these biomarkers into widespread use while exploring several novel ways in which they will help clinicians identify seizures.

PI_NAMEs: STACEY, WILLIAM CHARLES (contact)

PROGRAM_OFFICER_NAME: WHITTEMORE, VICKY R

PROJECT_TERMS: Address;Adoption;Algorithms;Area;Big Data Methods;Biological Markers;biomarker identification;Brain;Brain region;Caring;Characteristics;Classification;Clinical;clinical care;Clinical Data;clinical implementation;clinical practice;Clinical Research;clinical translation;Clinical Trials;Complex;Computational algorithm;Computer software;Data;Data Set;Databases;design;Detection;Diagnostic;Disease;Economics;Electroencephalography;Engineering;Epilepsy;Evaluation;Funding;Future;Goals;High Frequency Oscillation;Hippocampus;Hospitalization;Human;improved;Individual;interest;Learning;Location;Machine Learning;Manufacturer;Metadata;Methods;Modeling;Monitor;Nature;new technology;novel;novel marker;Operative Surgical Procedures;Pathologic;Pharmaceutical Preparations;Physiological;Physiology;potential biomarker;Process;Property;prospective;Reading;Research;Resolution;Seizures;Signal Transduction;Single Seizures;Sleep;spatiotemporal;specific biomarkers;Specificity;Techniques;Technology;technology/technique;Time;Tissues;tool;Translating;translational potential;Translations;Withdrawal;Work

PROJECT_TITLE: Characterizing High Frequency Oscillations as an epilepsy biomarker with Big Data tools

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;HIV/AIDS;Infectious Diseases;Mental Health;Mental Illness;Prevention;Social Determinants of Health;Violence Against Women;Violence Research;Women's Health Research

ORG_CITY: BOSTON

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: Project Narrative This study will evaluate the impact of the Common Elements Treatment Approach (CETA), an evidence-based intervention comprised of cognitive-behavioral therapy elements, at improving HIV treatment outcomes among women with HIV who have experienced intimate partner violence (IPV) and have an unsuppressed viral load on HIV treatment. To evaluate CETA, we will conduct a randomized controlled trial of HIV-infected women, with or without their partners, who have experienced IPV and have an unsuppressed viral load to test the effect of CETA in increasing viral suppression and reducing violence. We will also identify mediators and moderators of CETA’s effect on retention and viral suppression and assess the cost and cost-effectiveness of CETA vs. active control at increasing the proportion who are retained and virally suppressed by 12 months.

PI_NAMEs: FOX, MATTHEW ALEXANDER PEASE (contact);MURRAY, LAURA KAY

PROGRAM_OFFICER_NAME: SENN, THERESA ELAINE

PROJECT_TERMS: active control;Address;Adherence;Affect;Alcohol abuse;antiretroviral therapy;Anxiety;behavioral health;Caring;Clinical;Clinical Trials;Cognitive Therapy;Communities;comorbidity;cost;Cost Analysis;cost effective;cost effectiveness;Counseling;Diagnostic;Disease;Effectiveness;effectiveness evaluation;effectiveness testing;Elements;evidence base;Evidence based intervention;experience;Face;flexibility;HIV;improved;Individual;Infection;innovation;Intervention;intimate partner violence;Iraq;low and middle-income countries;male;Mediating;Mediator;Mental Depression;Mental Health;Modeling;Morbidity - disease rate;mortality;Movement;Outcome;patient-level barriers;Patients;Persons;Population;post-traumatic stress;Prevalence;primary outcome;Professional counselor;randomized trial;Randomized, Controlled Trials;Severities;South Africa;standard of care;substance use;Testing;Thailand;therapy adherence;transmission process;traumatic stress;Treatment outcome;treatment program;Violence;Viral;Viral Load result;Woman;women patients;women's outcomes;Work;Zambia

PROJECT_TITLE: Testing the effectiveness of an evidence-based transdiagnostic cognitive behavioral therapy approach for improving HIV treatment outcomes among violence-affected and virally unsuppressed women in SA


NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Mental Health;Mental Illness;Neurosciences;Pediatric

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE This project will examine how early variation in naturalistic emotion processing—how we attend to, interpret, and respond to emotional cues—are linked to risk for depression and anxiety in a large longitudinal sample of infants. Specifically, we will examine how neonatal activation to salient stimuli is linked to how infants attend to naturalistic emotions, and how this association is moderated by infant temperament. This proposal will therefore provide important insight to the etiology of depression and anxiety as well as important training opportunities in infant mental health methods.

PI_NAMEs: CAMACHO, MARIA CATALINA (contact)

PROGRAM_OFFICER_NAME: AVENILLA, FRANK R

PROJECT_TERMS: Age;Anxiety;Anxiety Disorders;Attention;auditory stimulus;Behavior assessment;behavioral response;Birth;Brain;Chad;Child;Chronic;Complex;Coupled;Cues;Data;design;Detection;Development;developmental neurobiology;Disease;Early Intervention;Emotional;emotional experience;emotional stimulus;Emotions;Etiology;Familiarity;Functional disorder;Functional Magnetic Resonance Imaging;Grant;high risk;Image;Individual Differences;infancy;Infant;infant temperament;insight;Link;Longitudinal Studies;maternal anxiety;Measures;Mental Depression;Mental disorders;Mental Health;Methods;Mothers;Neonatal;neonatal brain;neonate;neural;neurodevelopment;Newborn Infant;novel;parent grant;Process;Public Health;Regulation;response;Risk;Sampling;skills;Sleep;Stimulus;Symptoms;Temperament;Testing;Training;training opportunity;Variant;visual tracking;Work;Writing;Youth

PROJECT_TITLE: Neonatal predictors of contextualized emotion processing and risk for anxiety


NIH_SPENDING_CATS: Cardiovascular;Heart Disease

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

PHR: Heart failure (HF) refers to a condition in which the heart is either too weak to maintain a normal output or it does so at cost of high filling pressures causing congestion, as such patients with HF have symptoms related to low output such as fatigue and dizziness or related to congestion such as dyspnea and bloating. HF can be caused by many conditions, and its frequency is increasing becoming the most common heart condition, especially in the elderly, a segment of the population that is growing. Despite the improvement in therapies for HF, the number of patients suffering and dying from HF continues to be unacceptably high, suggesting that the current strategy misses one or more pathophysiologic mechanisms. We propose to explore the mechanism by which systemic inflammation, and Interleukin-1, an apical pro- inflammatory cytokine, in cardiac dysfunction and HF by studying an unconventional signaling not yet explored in the heart.

PI_NAMEs: ABBATE, ANTONIO ;TOLDO, STEFANO  (contact)

PROJECT_TERMS: Adaptor Signaling Protein;anakinra;Apical;beta-adrenergic receptor;Binding;Cardiac;Cardiac Myocytes;Cardiomyopathies;chemokine receptor;Clinical Research;cofactor;Coronary;cost;cytokine;Data;Death Rate;desensitization;Development;Diagnosis;Disease;Disease Marker;Dissociation;Dizziness;Dose;Dyspnea;Elderly;Epidemic;epidemiologic data;Exposure to;Fatigue;Frequencies;Functional disorder;G Protein-Coupled Receptor Signaling;G-Protein-Coupled Receptors;Gene Modified;Genetic;Heart;Heart failure;heart function;hospital readmission;Hospitalization;Hour;human old age (65+);improved;In Vitro;in vivo;Incidence;Inflammation;Inflammatory;Inflammatory Response;inhibitor;Interleukin-1;Interleukin-1 Receptors;Interruption;Ischemia;Knockout Mice;Knowledge;Ligation;Link;Malignant Neoplasms;Measures;Mediating;Mediator;Modeling;mouse model;mRNA Expression;Mus;Myeloid Cells;Myocardial dysfunction;Myocardial tissue;NF-kappa B;novel therapeutic intervention;novel therapeutics;Operative Surgical Procedures;Output;Pathway interactions;Patients;PDE 3B;pharmacologic;Phosphatidylinositols;Phosphotransferases;PIK3CG gene;Play;Population;preclinical study;Predisposition;preservation;pressure;Prevalence;prevent;Prognosis;Property;protein expression;Protein Isoforms;Proteins;Quality of life;Receptor Signaling;reduce symptoms;Role;scaffold;Signal Transduction;Small Interfering RNA;Symptoms;System;systemic inflammatory response;Testing;Time

PROJECT_TITLE: Unconventional IL-1 Signaling in Heart failure

STUDY_SECTION: CCHF

STUDY_SECTION_NAME: Cardiac Contractility, Hypertrophy, and Failure Study Section[CCHF]


ORG_CITY: CHICAGO

ORG_DEPT: PATHOLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE A stroke is caused by a lack of blood flow to the brain, usually due to the blockage of blood vessels, resulting in damage to the brain tissue. Inflammation, the body's reparative response to tissue damage, can worsen the initial damage to the brain produced by the stroke when blood flow is restored. Therefore, a better understanding of inflammation in the brain after a stroke may improve the effectiveness of anti-inflammatory therapies.

PI_NAMEs: ARIAS, ERIKA  (contact)

PROGRAM_OFFICER_NAME: BOSETTI, FRANCESCA

PROJECT_TERMS: Acute;acute stroke;Address;Adhesions;Affect;Alteplase;American;Animal Model;Anti-Inflammatory Agents;Antibodies;Area;Beds;Binding;Blocking Antibodies;Blood flow;Blood Vessels;Brain;Brain Hypoxia;Brain Ischemia;Brain Pathology;Brain region;brain tissue;Cause of Death;Cell Adhesion Molecules;Cell surface;Cells;Central Nervous System;Cerebral Ischemia;Cerebrovascular system;chemokine;Chronic;Clinical;Clinical Trials;clinically relevant;Coagulation Process;cytokine;Data;Development;disability;Effectiveness;Endothelial Cells;Endothelium;Event;Excision;Extravasation;Fellowship;Hypoxia;Immune;improved;improved outcome;in vivo;Infarction;Infiltration;Inflammation;Inflammatory;Inflammatory Response;Injury;insight;intravital imaging;intravital microscopy;Ischemia;Ischemic Stroke;Laboratories;Leucocytic infiltrate;Leukocytes;Lifelong disability;Location;Manuscripts;Mediator;Methods;migration;Minor;Modeling;mortality;Motor;Mus;Myeloid Cells;Necrosis;Nervous System Disorder;neutrophil;novel therapeutic intervention;Outcome;Paper;Pathologic;Pathology;Pathway interactions;Patients;Pattern;PECAM1 gene;Physicians;post stroke;preclinical study;prevent;protective effect;recruit;Reperfusion Injury;Reperfusion Therapy;Research;Resolution;response;restoration;Rodent Model;Role;Scientist;Signal Transduction;spatiotemporal;Stroke;stroke model;stroke outcome;stroke therapy;targeted treatment;Techniques;Testing;Therapeutic;Therapeutic Effect;Therapeutic Intervention;therapeutic target;thrombolysis;Time;Tissues;Training;Visit;White Blood Cell Count procedure;Work

PROJECT_TITLE: The Role of Neutrophils in Ischemia/Reperfusion Injury following Acute Stroke


ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Pulmonary arterial hypertension (PAH) is a progressive vascular disease with high morbidity and mortality. The etiology of PAH is poorly understood and currently there is no cure. This application aims to elucidate a role of DNA damage during the pathogenesis of PAH and to shed light on novel therapeutic strategies for PAH.

PI_NAMEs: HATA, AKIKO  (contact)

PROGRAM_OFFICER_NAME: XIAO, LEI

PROJECT_TERMS: Animal Model;Attenuated;attenuation;Blood Cells;Blood Vessels;bone morphogenetic protein receptors;Bone Morphogenetic Proteins;Cell Physiology;cell type;Cells;Cessation of life;Disease;DNA Damage;DNA Double Strand Break;DNA Repair;DNA Repair Pathway;Endothelium;Etiology;Gene Mutation;Gene Silencing;Genes;Genetic;genome integrity;Genomic Instability;Genotoxic Stress;genotoxicity;Goals;Heritability;Heterozygote;high risk;Homeostasis;homologous recombination;Human;insight;Knowledge;Link;Lung;Maintenance;Measures;Mediating;Messenger RNA;Molecular;Morbidity - disease rate;mortality;Mutation;mutation carrier;novel therapeutic intervention;novel therapeutics;Other Genetics;Pathogenesis;Pathologic;Patients;Penetrance;prevent;primary pulmonary hypertension;Progressive Disease;protein degradation;pulmonary arterial hypertension;Pulmonary arterial remodeling;pulmonary artery endothelial cell;Pulmonary artery structure;pulmonary vascular cells;Rare Diseases;Receptor Gene;Regulation;Reporting;right ventricular failure;Risk Factors;Role;Signal Pathway;Signal Transduction;Signaling Protein;Somatic Mutation;System;targeted treatment;Testing;Translating;Transplantation;Vascular Diseases;Vascular remodeling

PROJECT_TITLE: Molecular pathogenesis of pulmonary arterial hypertension

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: BERKELEY

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: Project Narrative Abnormalities in sensory processing or in sensory network integration are a common hallmark of neurodevelopmental and neurodegenerative disorders, such as autism spectrum disorder and Alzheimer disease. Understanding how sensory circuits develop is a significant goal in understanding these pathologies. Additionally, knowledge of the mechanisms underlying development of precise wiring patterns is critical to provide a framework for potential technologies or therapies for treating sensory-related disorders.

PI_NAMEs: BISTRONG, KARINA  (contact)

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: Adult;Alzheimer's Disease;Animals;Anterior;autism spectrum disorder;Calcium;Cells;Cerebral cortex;cholinergic;Complex;Data;design;Development;Disease;experience;Eye;ganglion cell;Genetic;Goals;Image;imaging detection;Inferior;information processing;insight;interest;Investigation;Knock-out;Knockout Mice;Knowledge;Label;Location;Maps;Mediating;Midbrain structure;Modeling;Motion;mouse model;Movement;Mus;neural circuit;Neurodegenerative Disorders;Neurodevelopmental Disorder;Nicotinic Receptors;Nose;optic flow;Optic Nerve;Pathology;Pattern;Peripheral;pharmacologic;Pharmacology;Population;postnatal;postsynaptic;Process;promoter;response;Retina;Role;Sensory;Signal Transduction;Source;Spatial Distribution;Specificity;starburst amacrine cell;stem;Surface;Synapses;synaptic inhibition;Technology;Testing;Thalamic structure;Thyrotropin-Releasing Hormone Receptors;tool;two-photon;Variant;Visual;visual information;visual stimulus;voltage clamp

PROJECT_TITLE: Assessing direction selectivity map development in the retina


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Genetics;Women's Health Research

ORG_CITY: NEW YORK

ORG_NAME: HUNTER COLLEGE

PHR: Approximately 80 % of triple negative breast cancers have mutations in the gene for the tumor suppressor p53 (TP53) and these cancers are aggressive and disproportionately affect the African American (AA) community. The proposed work will benefit all women with TNBC which would include the AA over-represented population. We discovered a set of interactions in human Triple Negative Breast Cancer (TNBC) cells between mutant p53 (mtp53), PARP, and MCM proteins which exists as a mtp53-PARP-MCM chromatin axis on replicating DNA. Understanding the mechanisms involved in mtp53 engaging more PARP and MCM proteins on chromatin during DNA damage, and testing for detection of mtp53 and PARP in TNBC, offer opportunities to expand TNBC knowledge. Completing this work will provide mechanistic insights on how mtp53 cross-talks with PARP and MCM proteins on chromatin in cell culture, xenograft models, and patient tissue. These studies will inform the potential of using the mtp53-PARP-MCM chromatin axis as a diagnostic and therapeutic (theranostic) hub, to detect and target nuclear co- expression of the biomarkers mtp53 and PARP. !

PI_NAMEs: BARGONETTI, JILL E. (contact)

PROGRAM_OFFICER_NAME: JOHNSON, RONALD L

PROJECT_TERMS: ADP ribosylation;Affect;African American;African American Women;African ancestry;African Women;Amino Acids;Animals;Area;Biological;Biological Markers;Biology;Breast Cancer Cell;Breast Cancer Patient;C-terminal;cancer cell;cancer imaging;cancer subtypes;Caring;Cell Culture Techniques;Cell Death;cell killing;Cell Line;Cells;Chromatin;Chromatin Remodeling Factor;cofactor;Communities;Complex;CRISPR/Cas technology;Data;Data Reporting;Data Set;Detection;Diagnostic;Disease;DNA;DNA Binding;DNA biosynthesis;DNA Damage;DNA replication fork;DNA-Protein Interaction;gain of function;Genes;Genetic Transcription;health disparity;Heat shock proteins;helicase;Human;imaging agent;imaging platform;Immunohistochemistry;Implant;improved;innovation;insight;knock-down;Knowledge;Maintenance;Malignant Neoplasms;Mammary Gland Parenchyma;MCM Protein;MCM2 gene;Mediating;Methods;Missense Mutation;Modeling;Molecular Analysis;mortality;mouse model;multi-ethnic;Multiprotein Complexes;Mus;mutant;Mutation;Neoplasm Circulating Cells;neoplastic cell;novel;Nuclear;Oncogenic;Outcome;Pathway interactions;patient derived xenograft model;Patients;Peptides;Phase;Poly(ADP-ribose) Polymerase Inhibitor;Poly(ADP-ribose) Polymerases;Population;Population Heterogeneity;Property;protein complex;Proteins;Publishing;Race;recruit;replication stress;Role;Scientist;screening;Signal Transduction;Sterol Biosynthesis Pathway;synergism;temozolomide;Testing;The Cancer Genome Atlas;theranostics;Therapeutic;Tissue Microarray;Tissues;TP53 gene;treatment choice;triple-negative invasive breast carcinoma;tumor;Tumor Promotion;Tumor Suppressor Genes;Tumor Volume;White Women;Woman;Work;Xenograft Model;Xenograft procedure

PROJECT_TITLE: The Role of the Mutant p53-PARP-MCM Pathway in Triple Negative Breast Cancer

STUDY_SECTION: TCB

STUDY_SECTION_NAME: Tumor Cell Biology Study Section[TCB]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Infectious Diseases;Rare Diseases;Tuberculosis

ORG_CITY: DURHAM

ORG_DEPT: GENETICS

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Project Narrative This project will investigate the granuloma, an organized aggregate of immune cells that forms in response to certain inflammatory stimuli, including infections with the bacteria that cause tuberculosis. The project aims to understand how granulomas form and how they contribute to the containment or growth and spread of infectious diseases like tuberculosis.

PI_NAMEs: TOBIN, DAVID M. (contact)

PROGRAM_OFFICER_NAME: SINGLETON, KENTNER L

PROJECT_TERMS: Adherens Junction;Affect;Animals;Appearance;Architecture;Bacteria;Biology;Cells;Chimera organism;combat;Communicable Diseases;Containment;Cues;Data;design;Desmosomes;Development;Disease;Disease Outcome;Disease Progression;E-Cadherin;epithelial to mesenchymal transition;Epithelium;Event;experimental study;Focal Adhesion Kinase 1;Genetic;Granuloma;Growth;Human;human disease;Image;Immune;Immune response;Immune signaling;Immune system;Individual;Infection;Inflammatory;Interleukin-13;Interleukin-4;Larva;Lead;Macrophage;Maintenance;Malignant Neoplasms;Marrow;Mediating;Mesenchymal;Modeling;Morphology;Motility;Mus;mutant;mycobacterial;Mycobacterium Infections;Necrosis;Neoplasm Metastasis;nonhuman primate;notch protein;novel therapeutic intervention;Optics;Outcome;overexpression;Pathway interactions;pharmacologic;Phenotype;Play;Process;programs;Reporter Genes;Resolution;response;Role;Signal Induction;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Source;STAT6 gene;Stimulus;Structure;Techniques;Testing;Tight Junctions;tool;Transgenic Organisms;Tuberculosis;Zebrafish

PROJECT_TITLE: Macrophage Reprogramming During Granuloma Formation in the Zebrafish

STUDY_SECTION: III

STUDY_SECTION_NAME: Innate Immunity and Inflammation Study Section[III]


ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

PHR: PROJECT NARRATIVE Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are the most common genetic cause of Parkinson's disease (PD). Current understanding of how LRRK2 mutations cause PD is lacking and will be key to combating this disease therapeutically. Our studies will explore novel mechanisms by which LRRK2 regulates neuronal morphology and how this goes awry with the common LRRK2 G2019S mutation as an important basis for understanding LRRK2-dependent PD and future therapeutic development efforts.

PI_NAMEs: MARTIN, IAN  (contact)

PROGRAM_OFFICER_NAME: SULLIVAN, LUIS FLANAGAN

PROJECT_TERMS: Adult;Affect;Age;age related;aged;Aging;animal old age;Automobile Driving;Biological Assay;Brain Diseases;Cytoskeleton;Defect;Development;Disease;Disease Progression;dopaminergic neuron;Drosophila genus;Environmental Risk Factor;Etiology;F-Actin;fly;Functional disorder;Future;Gene Silencing;Genes;Genetic;Genetic Screening;genome wide association study;Goals;Human;human data;Idiopathic Parkinson Disease;In Vitro;in vivo;insight;Lead;Length;life span;lifetime risk;LRRK2 gene;Maintenance;Measures;Mediating;Microtubules;Modeling;Molecular;Morphology;motor deficit;mRNA Translation;Mutation;Nature;Nerve Degeneration;neurite growth;Neurites;neuron loss;Neurons;neurotoxicity;novel;Orthologous Gene;overexpression;Parkinson Disease;Persons;Phenotype;Phosphotransferases;Prevalence;Prevention;Rattus;Regulation;Research;Role;Substantia nigra structure;technological innovation;Testing;Therapeutic;therapeutic development;therapeutic target;transcription factor

PROJECT_TITLE: LRRK2 in Parkinson's Disease Neurodegeneration

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Mental Health;Neurodegenerative

ORG_NAME: HEBREW REHABILITATION CENTER FOR AGED

ORG_STATE: MA

PHR: Delirium, an acute disorder of attention and cognition, is a common, life-threatening, and costly condition for older adults with strong links to Alzheimer’s Disease and Related Dementias (ADRD). The goal of the current proposal is to advance foundational research to develop more effective treatments for delirium. This goal will be accomplished by utilizing and expanding a research network, the Network for Investigation of Delirium: Unifying Scientists (NIDUS II), to bring together investigators across disciplines and institutions to conduct essential research to develop safe and effective treatments for delirium, and ultimately to improve outcomes for delirium in all older adults, particularly those with ADRD.

PI_NAMEs: INOUYE, SHARON K. (contact);JONES, RICHARD N

PROGRAM_OFFICER_NAME: ROBERTS, LUCI

PROJECT_TERMS: acute care;Acute Disease;Address;Aging;Alzheimer's disease patient;Alzheimer's disease related dementia;American;Area;Assessment tool;Attention;Award;Biological Markers;biomarker validation;career development;Clinical;clinical epidemiology;clinical predictors;Clinical Research;Clinical Treatment;Clinical Trials;Cognition;cost;Data;Data Analyses;data resource;Data Set;Databases;Delirium;design;Development;Diagnosis;Discipline;effective therapy;Ensure;Epidemiology;epidemiology study;Event;frailty;functional decline;Functional disorder;Future;Goals;Grant;Healthcare Systems;Human;Impaired cognition;improved outcome;Incidence;Individual;Infrastructure;innovation;Institution;Intensive Care;interdisciplinary collaboration;Interdisciplinary Study;interest;Investigation;Knowledge;Life;Link;Long-Term Care;Measurement;Measures;meetings;Mental Depression;Mentorship;Meta-Analysis;Methods;multiple chronic conditions;National Institute on Aging;novel;older adult;Outcome;outreach;Palliative Care;Paper;Participant;Pathway interactions;Patients;Pilot Projects;Prevention program;Principal Investigator;prognostic;Public Health;Quality of Care;R24;Research;Research Design;Research Infrastructure;Research Personnel;Resources;response;Risk Factors;Science;Scientific Advances and Accomplishments;Scientist;secondary analysis;Severities;support network;targeted therapy trials;therapeutic target;therapy development;Training;treatment strategy;treatment trial;webinar;working group

PROJECT_TITLE: NIDUS II: Advanced-Stage Development and Utilization of the NIDUS Research Infrastructure to Advance Interdisciplinary Aging Research in Delirium


ADMINISTERING_IC: EB

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_CITY: DAVIS

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Narrative Small-animal positron emission tomography (PET) is an in vivo molecular imaging technique widely used in preclinical research, however, the performance of currently available small-animal PET systems is far from reaching the theoretical limit in terms of spatial resolution and sensitivity, which limit its application in high resolution and fast dynamic imaging, such as imaging of mouse brain and obtaining image-derived input functions for kinetic modeling. We propose to develop a total-body small-animal PET system with a ~0.5 mm resolution and ~24.5 % sensitivity to enable high-resolution and fast dynamic imaging using mouse models. The improved performance will promote the use of total-body small-animal PET imaging for monitoring biological processes that result in fine structures and expand the range of applications for this powerful, non-invasive and translational imaging modality in preclinical applications.

PI_NAMEs: DU, JUNWEI  (contact)

PROGRAM_OFFICER_NAME: TORNAI, MARTIN PAUL

PROJECT_TERMS: Animals;Anodes;Aorta;Area;Biochemical;Biological Assay;Biological Models;Biological Monitoring;Biological Process;Brain;Brain imaging;Breast Microcalcification;Cathodes;Cells;cost;Coupled;data acquisition;Dedications;design;detector;Development;Diameter;disease model;Electronics;Evaluation;Event;fabrication;Funding;Glues;Goals;Human;Hybrids;Image;image translation;imaging modality;Imaging Techniques;improved;in vivo;Inflammation;kinetic model;Length;Light;Lutetium;Magnetic Resonance Imaging;Measurement;meter;Methods;molecular imaging;mouse model;Mus;nanomolar;Optics;Outcome;Output;parametric imaging;Performance;Perfusion;photomultiplier;Physiological;Polishes;Positioning Attribute;Positron-Emission Tomography;pre-clinical;pre-clinical research;preclinical imaging;preclinical study;Protocols documentation;radiotracer;Resolution;Signal Transduction;Silicon;Structure;Study models;System;Technology;temporal measurement;Thick;Time;tool;ultraviolet;Work;Yttrium

PROJECT_TITLE: A 0.5 mm resolution total-body small-animal PET

STUDY_SECTION: ITD

STUDY_SECTION_NAME: Imaging Technology Development Study Section[ITD]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Behavioral and Social Science;Brain Disorders;Clinical Research;Health Services;Mental Health;Networking and Information Technology R&D (NITRD);Patient Safety;Telehealth

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: Delirium, a form of acute brain dysfunction defined by acute change, inattention and a fluctuating course, is a devastating entity that is common in older adults and leads to negative patient outcomes. Little is known about the impact of delirium that persists beyond the time of discharge to the home environment on patient outcomes and day-to-day function immediately after discharge home. We will develop and establish the diagnostic accuracy of a telemedicine- based delirium assessment tool that can be utilized to assess for delirium in the home environment and facilitate further research of patients discharged home with active delirium.

PI_NAMEs: AUSTIN, CHARLES ADRIAN (contact)

PROJECT_TERMS: acceptability and feasibility;Activities of Daily Living;Acute;acute care;Adverse drug event;Age;Area Under Curve;Assessment tool;Attention;Blood Vessels;brain dysfunction;Cardiac;Caregivers;Cellular Phone;Cessation of life;Characteristics;Clinical;clinical care;clinical diagnosis;Clinical Research;Cognition;Cognition Disorders;cognitive testing;Confusion;confusion assessment method;cost;COVID-19 pandemic;Delirium;Dementia;Detection;Deterioration;Development;Devices;Diagnostic;diagnostic accuracy;diagnostic strategy;disability;Discipline of Nursing;Early Diagnosis;Enrollment;Event;experience;Family;feasibility testing;functional decline;Goals;heart function;Home;Home environment;Home Health Aides;Hospital Mortality;hospital readmission;Hospitalization;Hospitals;Impaired cognition;inattention;Infection;innovation;Inpatients;Institution;Institutionalization;interest;Intervention;Interviewer;Knowledge;Length of Stay;Life;Malignant Neoplasms;Medical;Medicine;Methods;mortality;mortality risk;Myocardial Infarction;new technology;older adult;Operative Surgical Procedures;Outcome;Participant;Patient Discharge;Patient-Focused Outcomes;Patients;Performance;Persons;Pharmaceutical Preparations;Pilot Projects;Population;Postoperative Period;Predictive Value;Prevalence;Prospective, cohort study;Recovery of Function;Reference Standards;Rehabilitation therapy;remote assessment;remote diagnosis;Research;Research Personnel;Resolution;Risk;Sensitivity and Specificity;Sepsis;Skilled Nursing Facilities;Specificity;statistics;Stroke;Tablet Computer;Telemedicine;Testing;Time;tool;Videoconferencing;Work

PROJECT_TITLE: Development and Assessment of Diagnostic Accuracy of a Telemedicine-Based Delirium Assessment Tool (The Tele-CAM)

STUDY_SECTION: CMGC

STUDY_SECTION_NAME: Clinical Management in General Care Settings Study Section[CMGC]