ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Aging;Atherosclerosis;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Endocrine Disruptors;Estrogen;Heart Disease;Menopause;Nutrition;Obesity;Prevention;Women's Health Research

ORG_CITY: Los Angeles

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: PROJECT NARRATIVE The proposed study is aimed to investigate the role of exposure to persistent organic pollutant mixtures in atherosclerosis progression among postmenopausal women who are at high risk of cardiovascular disease. This project can have international impact on identifying the detrimental chemical exposure that needs more attention and warrants stricter regulations on the chemical exposure level to enhance the cardiovascular health in the at- risk population.

PI_NAMEs: CHEN, ZHANGHUA ;KARIM, ROKSANA  (contact)

PROGRAM_OFFICER_NAME: JOUBERT, BONNIE

PROJECT_TERMS: Adverse effects;Affect;Age;Archives;arterial stiffness;Atherosclerosis;Attention;bioaccumulation;Biological Markers;Body fat;Body mass index;Cardiovascular Diseases;cardiovascular disorder prevention;cardiovascular disorder risk;cardiovascular effects;cardiovascular health;Cardiovascular system;Carotid Arteries;Carotid Atherosclerotic Disease;carotid intima-media thickness;Categories;Cause of Death;CCL2 gene;Chemical Exposure;Chemicals;chemokine;Cholesterol;Clinical Trials;cohort;Common carotid artery;Complex;Coronary Arteriosclerosis;cytokine;demographics;design;Diet;Double-Blind Method;E-Selectin;Endocrine;environmental chemical;Environmental Exposure;Estradiol;Estrogens;Exercise;experience;Exposure to;fasting glucose;Fatty acid glycerol esters;Freezing;Functional disorder;Gene Expression;Glucose;Glycosylated hemoglobin A;Goals;Gonadal Steroid Hormones;Health;High Density Lipoprotein Cholesterol;high risk;high risk population;Hormonal;hormone therapy;Hormones;Human;Human body;IL6 gene;IL8 gene;Immune;Individual;Inflammation;Inflammatory;Insulin Resistance;Intercellular adhesion molecule 1;Interleukin-10;International;Intervention Trial;intima media;intimal medial thickening;Joints;Knowledge;LDL Cholesterol Lipoproteins;Lipids;Lipoproteins;Long-Term Effects;Longitudinal Studies;Measurement;Measures;men;Menopausal Symptom;Menopause;Metabolic;Metabolic dysfunction;Midlife women;Morbidity - disease rate;mortality;Obesity;older adult;older men;Older Population;older women;organochlorine pesticide;Ovarian hormone;Oxidative Stress;P-Selectin;Pathologic;Pathology;Perimenopause;persistent organic pollutants;Pesticides;Physical activity;Physiological;Placebos;Plasma;pollutant;Poly-fluoroalkyl substances;polybrominated diphenyl ether;Polychlorinated Biphenyls;Population;Populations at Risk;Postmenopause;primary outcome;Proteins;Randomized;randomized, clinical trials;receptor;Receptor Signaling;Regulation;remediation;Reporting;Risk Factors;Role;Sampling;secondary outcome;Smoking;smoking exposure;socioeconomics;Special Population;Subgroup;TNF gene;Toxic effect;Treatment Factor;trial design;Triglycerides;Ultrasonography;ultrasound;Unhealthy Diet;United States;Vascular Cell Adhesion Molecule-1;Vascular Endothelial Growth Factors;Visit;Whole Blood;Woman;Women's mortality;Xenobiotics

PROJECT_TITLE: Circulating levels of Persistent Organic Pollutants and Subclinical Atherosclerosis progression in Postmenopausal women

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-N(91)S]


ADMINISTERING_IC: AR

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: ROCHESTER

ORG_COUNTRY: UNITED STATES

ORG_DEPT: ORTHOPEDICS

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF ROCHESTER

ORG_STATE: NY

PHR: Narrative  The project proposes to combine several state-of-the-art technologies to understand the molecular control of bone-specialized blood vessel formation and remodeling during long bone defect repair and reconstruction. Using the obtained knowledge, our goal is to create a biomimetic periosteum with growth factor releasing property, simulating the highly organized and functional periosteum for reconstruction of large bone defects.

PI_NAMEs: ZHANG, XINPING  (contact)

PROGRAM_OFFICER_NAME: MARQUITZ, ARON

PROJECT_TERMS: adenoviral mediated;allogenic bone transplantation;Allografting;angiogenesis;Autologous Transplantation;Biology;Biomimetics;blood vessel development;Blood Vessels;bone;Bone Growth;Bone Marrow;bone reconstruction;bone repair;Bone Resorption;Bone Surface;Cells;Chondrocytes;clinical translation;Coupling;Data;Defect;Deposition;Dose;Endothelial Cells;Engineering;Engraftment;Funding;gain of function;Genes;Goals;Growth Factor;healing;Homeostasis;Human;Immunofluorescence Immunologic;implantation;In Vitro;in vivo;insight;Knowledge;Label;long bone;Mediating;migration;mimetics;Modeling;Molecular;Molecular Profiling;mouse model;Mus;nanofiber;novel;Osteoblasts;Osteogenesis;osteogenic;overexpression;Pattern;Peptides;Periosteum;Polymers;Property;PTGS2 gene;reconstruction;regenerative;release factor;repaired;Role;Series;single-cell RNA sequencing;Site;spatiotemporal;Stromal Cells;subcutaneous;success;Surface;surface coating;Techniques;Technology;technology platform;Thinness;Tissue Engineering;Tissue membrane;Tissues;Transgenic Animals;Transgenic Mice;United States National Institutes of Health;vascular bed;Vascularization;Work

PROJECT_TITLE: Molecular control of blood vessel types at the regenerative interface for engineering of osteogenic and angiogenic periosteum mimetic


ADMINISTERING_IC: HL

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hypertension;Kidney Disease;Racial and Ethnic Minority Health Research

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Lysine specific demethylase-1 (LSD1) is an epigenetic regulator of gene transcription involved in the pathophysiology of elevated blood pressure and likely renal damage in Blacks. This project investigates whether Blacks who carry the risk allele for LSD1 (rs587168) have greater evidence of renal damage and whether a genetically driven anti-hypertensive approach proves superior in controlling blood pressure and mitigating renal injury. The findings of these investigations may lead to a new approach in treating a subset (~30%) of the essential hypertension population (Black LSD1 risk allele hypertensives) and have the potential to reduce Black- White disparities in health outcomes secondary to poor blood pressure control.

PI_NAMEs: HAAS, ANDREA  (contact)

PROGRAM_OFFICER_NAME: WEBB, STEPHANIE JOHNSON

PROJECT_TERMS: Address;Advisory Committees;Affect;Albumins;Albuminuria;Alleles;Amlodipine;antagonist;Anti-Hypertensive Agents;Basic Science;Biological Assay;Black Populations;Black race;black/white disparity;Blood Pressure;blood pressure control;blood pressure elevation;blood pressure reduction;blood pressure regulation;Calcium Channel;cardiovascular effects;Cardiovascular system;career;Chronic Kidney Failure;Clinical;Clinical Data;Clinical Trials Design;cohort;Collection;comorbidity;Creatinine;Cross-Sectional Studies;Data;Databases;Dedications;Development;Diet;Disease;Doctor of Philosophy;Double-Blind Method;drug efficacy;Endocrinology;Enrollment;Epigenetic Process;eplerenone;Essential Hypertension;Exhibits;Functional disorder;Future;Genes;Genetic Carriers;Genetic Markers;Genetic Polymorphism;Genetic Transcription;Goals;health disparity;Heart Diseases;High Prevalence;Human;Hypertension;hypertension control;hypertensive;hypertensives;improved;Individual;Injury to Kidney;International;Investigation;KDM1A gene;Kidney;Knowledge;Learning;Longitudinal Studies;Mediating;Mentors;Mentorship;Methodology;Mineralocorticoid Receptor;Mus;novel strategies;Outcome;Outpatients;Participant;patient oriented;Pharmaceutical Preparations;Physicians;Physiological;Physiology;Population;pre-clinical;precision medicine;Prevalence;primary outcome;Public Health Schools;Randomized;rat KIM-1 protein;Regulator Genes;renal damage;Research;Research Personnel;Research Proposals;Risk;risk variant;Role;Running;salt sensitive;Sampling;secondary outcome;Secondary to;side effect;skills;Sodium;Statistical Data Interpretation;statistics;Stroke;Techniques;Testing;tool;Training;Translational Research;treatment program;Tubular formation;United States;urinary;Urine;Variant;Visit;Wild Type Mouse;Work

PROJECT_TITLE: Role of LSD1 in Hypertension and Renal Injury in Blacks

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(MA)]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: UNIVERSITY PARK

ORG_DEPT: BIOLOGY

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

ORG_STATE: PA

PHR: Project Narrative  Understanding the genetic basis of complex phenotypes is a critical problem in medical and evolutionary genetics. My research program will focus on incorporating evolutionary information into the design and application of statistical methods for identifying the genomic basis of disease.

PI_NAMEs: SZPIECH, ZACHARY ALFANO (contact)

PROGRAM_OFFICER_NAME: ADKINS, RONALD

PROJECT_TERMS: Acceleration;Altitude;Area;biobank;Complex;Computer software;Data Set;design;Disease;disorder risk;diverse data;Evolution;Genetic;genetic architecture;genetic information;Genetic Variation;Genome;genome sequencing;genomic data;Genomic Segment;genomic variation;Genomics;Haplotypes;Hispanic Community Health Study/Study of Latinos;Homozygote;Human;Human Genome;Individual;Knowledge;Learning;Macaca mulatta;Medical;Methodology;Methods;Modeling;Modernization;Natural Selections;Nature;novel;pathogen exposure;Phenotype;phenotypic data;Population;Population Genetics;Population Process;Process;programs;Recording of previous events;Research;Resources;Shapes;Statistical Methods;statistics;Theoretical model;trait;Trans-Omics for Precision Medicine;Variant;Work

PROJECT_TITLE: Population Genetics Methods for Understanding Complex Trait Evolution

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-GGG-S(55)]


ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Cardiovascular;Diabetes;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Nutrition

ORG_CITY: HERSHEY

ORG_DEPT: PHYSIOLOGY

ORG_NAME: PENNSYLVANIA STATE UNIV HERSHEY MED CTR

PHR: Project Narrative A deficit in our understanding of the molecular defects that underlie the development of heart disease represents a critical barrier to the design and implementation of therapeutics that more fully address its molecular pathogenesis. The present application will identify a novel mechanism that potentially regulates the endogenous antioxidant and inflammatory responses of the heart in diabetes. These findings are expected to provide new targets for intervention and lead to the development of innovative therapies for a leading cause of mortality and morbidity.

PI_NAMEs: STEVENS, SHAUNACI  (contact)

PROGRAM_OFFICER_NAME: CHEON, YEWON

PROJECT_TERMS: Ablation;Acute-Phase Proteins;Address;Adult;Antioxidants;Attenuated;biological adaptation to stress;Biological Models;Cardiac;Cardiac Myocytes;Cardiovascular Diseases;Cardiovascular system;Cell Culture Techniques;Cell Line;Cell Physiology;chemokine;college;combat;Complex;Consumption;cytokine;Data;db/db mouse;Defect;design;Development;Diabetes Mellitus;Diabetic mouse;Diet;Disease;DNA Damage;Dyslipidemias;Echocardiography;endoplasmic reticulum stress;Event;Exposure to;Failure;Fatty acid glycerol esters;Fellowship;FRAP1 gene;Functional disorder;Gene Chips;gene product;Genetic Transcription;glycogen synthase kinase 3 beta;Guanine Nucleotide Exchange Factors;Heart;heart defect;Heart Diseases;Heart failure;heart function;Hypoxia;Impairment;Infarction;Inflammation;Inflammatory;Inflammatory Response;inhibitor;Innovative Therapy;insight;Intervention;Ischemia;Knockout Mice;Laboratories;Learning;Lipids;Macrophage;Medicine;Metabolic Diseases;Modeling;Molecular;Molecular and Cellular Biology;Morbidity - disease rate;mortality;mRNA Translation;Mus;Myocardial;Myocardial dysfunction;Myocardial Infarction;NF-kappa B;novel;nuclear factor-erythroid 2;Obese Mice;Obesity;Open Reading Frames;Outcome;Oxidative Stress;Oxidative Stress Induction;Palmitates;Pathogenesis;Pathologic;Patients;Phosphorylation;Phosphotransferases;Play;prevent;preventive intervention;Production;Protein Biosynthesis;protein expression;protein kinase R;Proteins;Protocols documentation;Reperfusion Therapy;Repression;response;Retina;Role;Saturated Fatty Acids;sensor;Signal Transduction;skills;Stress;Stress-Induced Protein;Sucrose;Systems Analysis;Technical Expertise;Testing;Therapeutic;Therapeutic Intervention;Training;training opportunity;transcription factor;Transgenic Mice;Up-Regulation;Ventricular;western diet;Wild Type Mouse

PROJECT_TITLE: Role of Diabetes-Induced REDD1 in Heart Disease


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Clinical Research;Infectious Diseases;Malaria;Prevention;Rare Diseases;Vector-Borne Diseases

ORG_CITY: BALTIMORE

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: PROJECT NARRATIVE Differences in the responses of mosquito populations to malaria interventions, both within species and between species, may impact intervention effectiveness, yet important aspects of this diversity remain poorly characterized. In this study, I will use a combination of field and laboratory data together with advanced computational methods to examine differences in vector competence between mosquito species and migration patterns within mosquito species. The results will improve our understanding of the current persistence of malaria parasite transmission.

PI_NAMEs: MCCANN, ROBERT SEAN (contact)

PROGRAM_OFFICER_NAME: SINA, BARBARA J

PROJECT_TERMS: Address;Africa;Anopheles gambiae;Anopheles Genus;Area;Beds;Bioinformatics;bioinformatics tool;Biological;Biological Assay;Biology;Bite;Blood;career development;Computing Methodologies;Country;Culicidae;Data;Development;Development Plans;Diagnosis;Eastern Africa;Ecology;effective therapy;Effectiveness;Effectiveness of Interventions;Environment;Evaluation;Exhibits;Faculty;feeding;Genes;Genetic;Genome;Genomics;Geography;global health;Goals;improved;Infection;infectious disease model;Insecticide Resistance;Insecticides;interdisciplinary collaboration;International;Intervention;Knowledge;Laboratories;Literature;Location;Malaria;malaria transmission;Malawi;Maryland;Measures;medical schools;Membrane;Mentors;Methods;migration;Modeling;multidisciplinary;Oocysts;Parasites;Pattern;Plasmodium falciparum;Policies;Population;Population Genetics;Predisposition;preference;Prevalence;Principal Investigator;programs;Research;Research Personnel;resistance mechanism;Resistance profile;response;Rest;Sampling;Science;skills;South Africa;Southern Africa;Structure;therapy design;tool;Training;transmission process;Universities;Use Effectiveness;Variant;vector;vector competence;vector control;Vector Ecology

PROJECT_TITLE: Impact of malaria vector diversity on intervention strategies

STUDY_SECTION_NAME: International and Cooperative Projects - 1 Study Section[ICP1]


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Physical Injury - Accidents and Adverse Effects;Women's Health Research

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: NARRATIVE Females experience musculoskeletal disease and injuries at differing rates than males; yet, the reasons for these differences are poorly understood. The goal of this work is to develop a quantitative framework to examine how sex differences in musculoskeletal structure influence movement biomechanics, musculoskeletal injury, and neuromuscular disease. .

PI_NAMEs: BLEMKER, SILVIA SALINAS (contact)

PROGRAM_OFFICER_NAME: WASHABAUGH, CHARLES H

PROJECT_TERMS: Acceleration;Address;Adult;Affect;Age;Algorithms;Anatomy;Architecture;Biomechanics;Body mass index;Body Size;bone;Case Study;Communities;computer framework;Computer Models;Computer Simulation;Data;Data Set;Databases;digital;Disease;Electromyography;Elements;empowerment;Ensure;experience;Female;Future;Gait;Goals;health care disparity;Height;imaging approach;Incidence;Individual;Injury;injury recovery;innovation;insight;Joints;kinematics;Kinetics;Knee Injuries;Lead;limb movement;Lower Extremity;Magnetic Resonance Imaging;male;Measurement;Measures;Mechanics;Methods;Modeling;models and simulation;Motor;Movement;Muscle;Muscle function;muscle strength;Musculoskeletal;Musculoskeletal Diseases;musculoskeletal injury;Musculoskeletal structure;Musculoskeletal System;neuromuscular;Neuromuscular Diseases;novel;Physical Function;Population;population based;Predisposition;prospective;Publishing;Research;Research Personnel;research study;Resource Sharing;Resources;Role;segmentation Image analysis;sex;sex as a biological variable;Sex Differences;simulation;skeletal;Skeleton;Testing;tool;Uncertainty;usability;Walking;women subjects;Work

PROJECT_TITLE: A quantitative framework to examine sex differences in musculoskeletal scaling and function

STUDY_SECTION: MRS

STUDY_SECTION_NAME: Musculoskeletal Rehabilitation Sciences Study Section[MRS]


ADMINISTERING_IC: HD

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Biotechnology;Contraception/Reproduction;Genetics;Human Genome;Infertility;Women's Health Research

ORG_CITY: PISCATAWAY

ORG_NAME: RUTGERS, THE STATE UNIV OF N.J.

ORG_STATE: NJ

PHR: Project Narrative Infertility is a disease that affects 1 in 10 women in the United States and a leading cause of female infertility is having an abnormal number of chromosomes (aneuploidy) in eggs and embryos. This proposal investigates genetic variants found in women who are predisposed to having more chromosomally abnormal eggs than would be typical for their age group. The outcome of this work, knowledge of the effect of these genetic variants on egg development, will lay the foundation for development of genetic tests that could help women and their physicians to non-invasively assess predisposition to having chromosomally abnormal eggs and thus infertility.

PI_NAMEs: BISWAS, LEELABATI  (contact)

PROGRAM_OFFICER_NAME: TAYMANS, SUSAN

PROJECT_TERMS: Address;advanced maternal age;Affect;Age;age group;Aneuploidy;arm;Biological Assay;Biology;Candidate Disease Gene;career;causal variant;Cell division;Chromosome abnormality;chromosome number abnormality;Chromosome Segregation;Chromosomes;Clinic;clinical diagnostics;clinical training;Complex;computerized tools;Conceptions;Coupled;Creativeness;Data;Data Set;Decision Making;Defect;design;Development;Disease;egg;Embryo;Ensure;Etiology;Evaluation;Event;exome sequencing;experience;experimental study;Faculty;Failure;Female;female fertility;Female infertility;Fertility;Fiber;Foundations;Gametogenesis;Genes;Genetic;Genetic Diseases;genetic predictors;genetic resource;Genetic Screening;genetic testing;genetic variant;Genetic Variation;Genomics;Goals;Habitual Abortion;Healthcare;Human Genetics;Impairment;in silico;Infertility;insight;Kinesin;Kinetics;Knock-in;Knock-in Mouse;Knowledge;Length;Link;live cell imaging;Maternal Age;Maternal-fetal medicine;Meiosis;Mentors;Microscopy;Microtubules;Modeling;Modernization;Molecular;Molecular Analysis;Monitor;Morphology;Motor;mouse model;Mus;Mutation;New Jersey;next generation sequencing;novel;Oocytes;Outcome;overexpression;Pathogenicity;Patients;Perinatal;Physicians;predictive tools;Predisposition;Process;Productivity;prognostic;protein structure;Proteins;Reproduction;reproductive;Reproductive Endocrinology;Reproductive Health;reproductive system disorder;Research;research facility;research study;Research Training;Resolution;Risk;Scientist;subfertility;Testing;tool;Training;Training Programs;United States;Universities;Validation;Variant;Woman;women's reproductive health;Work

PROJECT_TITLE: Functional evaluation of kinesin gene variants associated with female subfertility and egg aneuploidy.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F06-B(20)L]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: AUGUSTA

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: AUGUSTA UNIVERSITY

ORG_STATE: GA

PHR: The proposed study will uncover the molecular mechanisms underlying generation of protective antibody response following vaccination or infection. The knowledge gained from this study will help in designing better vaccines and treatments for pathologies related to antibody secreting cells.

PI_NAMEs: SINGH, NAGENDRA  (contact)

PROGRAM_OFFICER_NAME: CASTLEMAN, MORIAH JOVITA

PROJECT_TITLE: Regulation of antibody secreting cell (ASC) homeostasis by Ufbp1.

STUDY_SECTION: CMIA

STUDY_SECTION_NAME: Cellular and Molecular Immunology - A Study Section[CMIA]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Immunotherapy;Infectious Diseases;Influenza;Lung;Pneumonia;Pneumonia and Influenza;Rare Diseases

ORG_CITY: BAR HARBOR

ORG_NAME: JACKSON LABORATORY

ORG_STATE: ME

PHR: Influenza viruses are rapidly mutating RNA viruses and the causative agent of about one billion annual respiratory virus infections and 500,000 deaths worldwide, and viral resistance has developed to all available treatment options. We recently generated novel and compelling evidence that influenza virus infection triggers lung innate immune cells to suppress helpful antiviral immune responses, perhaps to reduce harmful immuno- pathology. We propose to determine the mechanisms regulating viral clearance versus lung pathology, as this knowledge will provide the rationale to develop novel therapeutics augmenting the antiviral immune response while preventing detrimental immunopathology, greatly improving public health.

PI_NAMEs: PAUST, SILKE  (contact)

PROGRAM_OFFICER_NAME: JOFFE, AARON MICHAEL

PROJECT_TERMS: Acute;Acute Respiratory Distress Syndrome;Address;Anti-Inflammatory Agents;Anti-viral Agents;Anti-viral Response;antiviral immunity;B-Lymphocytes;Bacterial Infections;Bacterial Pneumonia;CD80 gene;Cell Physiology;cell type;Cells;Cessation of life;chronic infection;cytokine;Cytotoxic T-Lymphocytes;Data;Disease;Epidemic;exhaustion;fighting;Granzyme;Health;Human;humoral immunity deficiency;Hyperimmunoglobulin M Syndrome;Hypoxia;Immune;immune cell infiltrate;Immune response;Immunity;immunopathology;immunoregulation;improved;In Vitro;Infection;Inflammation;Influenza;Influenza A virus;influenza infection;Influenza prevention;influenzavirus;Interferon Type II;Interleukin-10;interleukin-10 receptor;Knockout Mice;Knowledge;Ligands;Lung;Lymphocyte;Lymphocyte Function;Malignant Neoplasms;mast cell;Mediating;Morbidity - disease rate;mortality;Multiple Organ Failure;Mus;Mutate;Natural Killer Cells;neutralizing antibody;novel;novel therapeutics;Outcome;pandemic potential;Pathway interactions;PDL1 pathway;Persons;pharmacologic;Phenotype;Population;prevent;programmed cell death ligand 1;programmed cell death protein 1;Public Health;Pulmonary Pathology;Rag1 Mouse;respiratory infection virus;response;RNA Viruses;Role;Seasons;Severity of illness;Signal Pathway;Signal Transduction;Slice;Structure of parenchyma of lung;Suspensions;T cell regulation;T-Lymphocyte;Therapeutic;therapeutic target;tumor;vaccination outcome;Viral;Viral Pneumonia;viral resistance;Virus;Virus Diseases;Virus Replication;Wild Type Mouse;Work

PROJECT_TITLE: Novel mechanisms regulating immunity to respiratory virus infection

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IIDA-M(90)]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Pediatric;Social Determinants of Health

ORG_CITY: IOWA CITY

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: NARRATIVE Developmental Language Disorder (DLD) in adulthood is severely under-researched, and the consequences are dire: adults with DLD are less likely to seek post-secondary education4 , have extended bouts of unemployment, and higher rates of depression. The current project takes a fundamental step toward illuminating what underlies these profoundly negative effects by characterizing language abilities and mechanisms that explain language deficits in adults with DLD. The proposed research will lay the groundwork for legislative efforts to provide service provision for adults with DLD, and prompt applied research to improve the transition from youth to adulthood in this population.

PI_NAMEs: HENDRICKSON, KRISTI  (contact)

PROGRAM_OFFICER_NAME: STORKEL, HOLLY LYNN

PROJECT_TERMS: Address;Adolescence;Adult;Advocate;Affect;Applied Research;Area;Bayesian Analysis;Child;Childhood;Client;Clinical;Cognitive;cohort;Communication;Complex;Comprehension;Data Set;density;Development;Disease;Evolution;Family;Goals;Growth;improved;Income;Individual Differences;information processing;Intervention;Iowa;kindergarten;Knowledge;Language;language comprehension;Language Development Disorders;Language Disorders;language outcome;language processing;Learning;lexical;life span;Linguistics;Link;longitudinal dataset;Longitudinal Studies;Measures;Mediating;Mental Depression;Modality;Modeling;National Institute on Deafness and Other Communication Disorders;Neurodevelopmental Disorder;Outcome;Outcome Measure;Participant;peer;Performance at work;Personal Satisfaction;Population;Prevalence;Prevention;Process;processing speed;Production;Protocols documentation;recruit;Research;Research Personnel;Secondary Schools;Service delivery model;Service provision;Short-Term Memory;skills;Speech;Speed;syntax;tenth grade;Testing;theories;Time;trait;Unemployment;Variant;Visual;visual tracking;Work;Workplace;Youth

PROJECT_TITLE: Language outcomes, mechanisms, and trajectories in adults with and without Developmental Language Disorder

STUDY_SECTION: LCOM

STUDY_SECTION_NAME: Language and Communication Study Section[LCOM]


NIH_SPENDING_CATS: Genetics;HIV/AIDS

ORG_CITY: PITTSBURGH

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: NARRATIVE Our group has developed cutting-edge technology - “on-the-fly” time-resolved cryo-electron microscopy (EM) - that, for the first time, facilitates visualization of novel protein conformations, including those transiently occurring during catalysis. In this application, we will apply this technology to address biologically and clinically relevant knowledge gaps in HIV-1 reverse transcriptase (RT) biology, with specific focus on the incorporation of nucleosides and nucleoside inhibitors, nucleoside inhibitor resistance, and the relationship between DNA synthesis and ribonuclease H activity.

PI_NAMEs: CALERO, GUILLERMO ALBERTO (contact);DEITERS, ALEXANDER ;SLUIS-CREMER, NICOLAS PAUL

PROGRAM_OFFICER_NAME: NOVAK, LEIA KAYE

PROJECT_TERMS: Active Sites;Address;Amino Acids;Binding;Biological Process;Biology;Catalysis;Chemicals;clinically relevant;computer studies;Cryoelectron Microscopy;Data;Development;DNA;DNA analysis;DNA biosynthesis;DNA-Directed DNA Polymerase;DNA-Directed RNA Polymerase;drug action;Drug resistance;Enzymes;Event;Excision;experience;experimental study;flexibility;HIV-1;inhibitor;innovation;Investigation;Ions;Kinetics;Knowledge;Mediating;Molecular;Molecular Conformation;Motion;movie;novel;novel therapeutics;Nucleic Acids;nucleoside inhibitor;Nucleosides;Nucleotides;Pathway interactions;photoactivation;Play;Polymerase;Positioning Attribute;Protein Conformation;Proteins;Reaction;Research Personnel;Resistance;resistance mutation;Reverse Transcriptase Inhibitors;Reverse Transcription;Ribonuclease H;RNA;RNA Degradation;RNA-Directed DNA Polymerase;Role;Site-Directed Mutagenesis;small molecule;structural biology;structural determinants;Structure;Technology;Thermodynamics;Time;tool;tripolyphosphate;Validation;Variant;Visualization;Work;X-Ray Crystallography;Zidovudine

PROJECT_TITLE: "On the Fly" Time Resolved Cryo-EM Studies of Intermediate HIV-1 RT Transition States

STUDY_SECTION: HVCD

STUDY_SECTION_NAME: HIV Molecular Virology, Cell Biology, and Drug Development Study Section[HVCD]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Lung;Nutrition;Rare Diseases;Tuberculosis

ORG_CITY: Newark

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

PHR: Project narrative This program studies the function of newly discovered one-carbon metabolism in mediating the expression of host innate and adaptive immunity against infection by Mycobacterium tuberculosis, the causative agent of tuberculosis (TB), and evaluates HDTs targeting it to improve bacillary clearance and prevent immunopathology.

PI_NAMEs: SALGAME, PADMINI ;SHI, LANBO  (contact)

PROGRAM_OFFICER_NAME: ROBINSON, RICHARD THOMAS

PROJECT_TERMS: adaptive immunity;Adult;Advanced Development;Animal Model;Antimycobacterial Agents;Antitubercular Agents;Area;Biology;C3HeB/FeJ Mouse;cancer cell;Carbon;Cell Lineage;Cell Physiology;Cells;Chronic;Communicable Diseases;Cysteine;Development;dietary;Dietary intake;Disease;Disease Progression;efficacy testing;Enzymes;experience;Feedback;Folic Acid;Folic Acid Deficiency;folic acid supplementation;Formates;Gene Expression Profiling;Generations;Glutathione;Glycine;Homeostasis;hypoxia inducible factor 1;Immune;immune activation;Immunity;immunopathology;improved;in vivo;Infection;Infection Control;Inflammatory;inhibitor;Knockout Mice;Lung;Macrophage;Mediating;Metabolic;Metabolic Pathway;Metabolism;metabolomics;Methionine;Methods;Methylation;Mitochondria;mitochondrial metabolism;mouse model;Mouse Strains;Mus;Mycobacterium tuberculosis;Myeloid Cells;NADH;NADP;Natural Immunity;novel;nucleotide metabolism;Oxidation-Reduction;Oxidoreductase;Pathogenesis;Pathology;Pathway interactions;Pharmaceutical Preparations;Population;Predisposition;prevent;programs;Proliferating;Property;Pulmonary Pathology;Purine Nucleotides;Reaction;Research;Research Personnel;response;Role;Serine;Severity of illness;side effect;Signal Pathway;Signal Transduction;Signaling Molecule;Sirolimus;T-Lymphocyte;targeted treatment;Testing;Tetrahydrofolates;Therapeutic;Tissues;transcriptomic profiling;Tuberculosis;tuberculosis treatment;Up-Regulation;Warburg Effect

PROJECT_TITLE: One-carbon metabolism and immune cell function in tuberculosis

STUDY_SECTION: BHI

STUDY_SECTION_NAME: Bacterial-Host Interactions Study Section [BHI]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurodegenerative;Neurosciences;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY

PHR: Project Narrative Maintaining safe nursing home staffing levels during public health emergencies is of critical importance to the growing population of residents living with Alzheimer’s disease or related dementias. Our proposal seeks to understand the effectiveness and equity of federal emergency funding that directly supports nursing home staffing, with an overall goal to develop a framework by which to guide future nursing home responses to public health emergencies.

PI_NAMEs: FALVEY, JASON RAYMOND;TRAVERS, JASMINE  (contact)

PROGRAM_OFFICER_NAME: FAZIO, ELENA

PROJECT_TERMS: Address;Alzheimer's disease related dementia;American;Area;Behavior;Businesses;Caring;Characteristics;Clinical;cohort;community-level factor;COVID-19;COVID-19 pandemic;Data;Dementia;deprivation;design;Development;Diagnosis;Disasters;Disparity population;econometrics;economic disparity;Economic Factors;Economics;Effectiveness;effectiveness evaluation;Eligibility Determination;Emergency Situation;Equity;Event;Excess Mortality;experience;federal policy;Funding;Future;Goals;Health;Health care facility;health disparity;Health Personnel;Health Services Research;Home Nursing Care;Hour;improved;improved outcome;indexing;Individual;Infrastructure;Intervention;Interview;Leadership;Medicare;Methods;mortality;Natural experiment;Neighborhoods;Nurse Administrator;nursing care quality;Nursing Homes;Nursing Staff;older adult;Outcome;pandemic disease;Pattern;Phase;Policies;Population;Preparation;prevent;programs;promote resilience;Public Health;public health emergency;Qualitative Research;Quality of Care;Reporting;resilience;resilience factor;Resources;response;Safety;Shock;Social Environment;socioeconomics;Structure;Survey Methodology;Surveys;telehealth;Time;tool;ventilation;Work

PROJECT_TITLE: The Paycheck Protection Program and its Effects on Staffing Patterns and the Outcomes of Residents Living with Dementia


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Foodborne Illness;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Microbiome;Pediatric;Prevention;Rural Health;Social Determinants of Health

ORG_CITY: CORVALLIS

ORG_NAME: OREGON STATE UNIVERSITY

ORG_STATE: OR

PHR: NARRATIVE The ever-increasing production and use of chemicals, potable water reuse, climate change, growing populations, and intensive farming are factors that drive drinking water contamination, which has been linked with epidemic diseases such as cancer, obesity, and impaired mental functions, and has particularly hazardous effects on fetal, infant, and child health. My studies will combine state-of-the-art high-resolution mass spectrometry with innovative high-throughput in vivo and in vitro effect-directed analyses to expand the coverage of current drinking water monitoring strategies, together with a novel statistical mediation approach to assess host microbiota interactions in the zebrafish model, as affected by drinking water contaminants. I will develop effective and scalable assessment tools for the identification and prioritization of complex contaminant mixtures in urban and rural drinking water; establish the foundation for the discovery of biomarkers of exposure to drinking water contaminants in future studies; and facilitate the translation of our results to study participants across Oregon.

PI_NAMEs: GARCIA-JARAMILLO, MANUEL  (contact)

PROGRAM_OFFICER_NAME: RAVICHANDRAN, LINGAMANAIDU V

PROJECT_TERMS: Adolescent;Adult;Affect;Area;Assessment tool;Behavioral;Biological Assay;biomarker discovery;Body Weight;Bottle feeding;Chemicals;Child;Child Health;climate change;community engaged approach;Complex;contaminated drinking water;contaminated water;Data;Detection;developmental disease;Diet;Disease;drinking water;Environmental Health;Epidemic;Exposure to;Farm;Fetal health;Foundations;Future;gastrointestinal system;Goals;gut microbes;gut microbiota;Health;host microbiota;human subject;Impairment;improved;in silico;In Vitro;in vivo;Infant;Infant Health;innovation;Intestines;Knowledge;late life;Life;Link;Malignant Neoplasms;Mass Spectrum Analysis;Mediating;Mediation;member;mental function;Metabolism;metabolomics;Methods;microbiome;microbiome analysis;Modeling;Monitor;Municipalities;National Institute of Environmental Health Sciences;Neurologic;novel;novel strategies;Obesity;open source;Oregon;Organ;Organic Chemicals;organic contaminant;Outcome;Participant;Physiological;Poison;pollutant;Population;Population Growth;Privatization;Production;Public Health;Regulation;reproductive system disorder;Resolution;response;Retinal blind spot;Risk;Risk Assessment;Rural;Rural Community;safety assessment;Sampling;Services;socioeconomic development;Source;Strategic Planning;Surface;Testing;Time;Tissues;Toxic effect;Toxicity Tests;Toxicology;Translations;Variant;Water;Water Pollutants;water quality;water sampling;water testing;water treatment;web site;well water;Work;Zebrafish

PROJECT_TITLE: Protecting children's health by applying novel approaches to assess urban and rural drinking water


ADMINISTERING_IC: CA

ED_INST_TYPE: HOSPITALS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Genetics;Immunotherapy;Ovarian Cancer;Rare Diseases;Women's Health Research

ORG_CITY: HOUSTON

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: Project Narrative The proposed research is relevant to public health because it will reveal a critical molecular switch that controls the senescence-associated secretory phenotype, an important tumor regulating mechanism. These molecular insights may provide the scientific rationale to ultimately develop novel strategies to overcome therapy relapse and/or resistance for cancers including ovarian cancer, the most lethal gynecological malignancy in the United States. Therefore, the proposed research is relevant to the part of the NIH’s mission that pertains to developing fundamental knowledge that will reduce the burden of human illness.

PI_NAMEs: ZHANG, RUGANG  (contact)

PROGRAM_OFFICER_NAME: CERO, CHERYL

PROJECT_TERMS: Active Sites;BRCA mutations;cancer cell;Cancer Patient;Caring;CD8-Positive T-Lymphocytes;Cell Aging;cell growth;Cell Proliferation;Cell Survival;chemokine;chemotherapy;Chromatin;Cisplatin;cytokine;Cytoplasm;Data;Development;DNA;ds-DNA;Epithelial ovarian cancer;experimental study;Foundations;Gene Expression;Goals;Growth;Growth Factor;Human;Immune;immune checkpoint blockade;Immunocompetent;Impairment;in vivo Model;innate immune pathways;insight;Knowledge;Malignant Female Reproductive System Neoplasm;Malignant neoplasm of ovary;Malignant Neoplasms;Mediating;Mission;Modeling;Molecular;mouse model;Natural regeneration;neoplastic cell;novel;novel strategies;novel therapeutic intervention;Oxidation-Reduction;Pathway interactions;Patients;Pattern Recognition;Platinum;prevent;Proteins;Public Health;Publishing;Regulation;Relapse;relapse prevention;Research;Resistance;Role;senescence;senescence associated secretory phenotype;senescent cell;sensor;Series;Signal Pathway;Signal Transduction;standard of care;stem-like cell;Stimulator of Interferon Genes;T cell infiltration;Therapeutic;therapy resistant;thioredoxin reductase 1;treatment response;tumor;tumor progression;Tumor Promotion;TXN gene;United States;United States National Institutes of Health;Up-Regulation;VEGFA gene;Xenograft procedure

PROJECT_TITLE: Signaling basis of senescence-associated secretory phenotype and its implications in epithelial ovarian cancer

STUDY_SECTION: ATA

STUDY_SECTION_NAME:
Advancing Therapeutics A Study Section
[ATA]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: PHOENIX

ORG_NAME: TRANSLATIONAL GENOMICS RESEARCH INST

ORG_STATE: AZ

PHR: NARRATIVE Obesity is an established risk factor for the development of type 2 diabetes (T2D), yet for reasons that are unclear, many obese individuals will never develop T2D as a result of increased adiposity. This study will identify molecular factors associated with T2D in obese individuals and characterize what happens to these factors following T2D remission and substantial weight loss from bariatric surgery. Results of this work may lead to an improved understanding of how T2D develops and identify new therapeutic targets for the treatment of T2D.

PI_NAMEs: DISTEFANO, JOHANNA K (contact);GERHARD, GLENN S

PROGRAM_OFFICER_NAME: SECHI, SALVATORE

PROJECT_TERMS: Address;Adipocytes;adipokines;Adipose tissue;Age;Analysis of Variance;bariatric surgery;Biological Assay;Body mass index;Body Weight decreased;candidate validation;Cell Communication;cell type;Cells;cellular targeting;Chronic;Classification;cohort;Conditioned Culture Media;Development;Diabetes Mellitus;diabetic;Disease remission;drug development;Ethnic Origin;experience;extracellular vesicles;fatty acid-binding proteins;Genes;Genetic Transcription;Glucose Intolerance;glucose metabolism;glucose tolerance;glycemic control;Human;improved;Individual;Inflammation;Inflammatory;Insulin Resistance;Investigation;ITGAM gene;Knowledge;Lead;Link;Lipids;lonely individuals;Macrophage;Mass Spectrum Analysis;Measures;Mediating;Mediator;member;Membrane;Messenger RNA;Metabolic;MicroRNAs;Mining;Modeling;Molecular;Morbid Obesity;morphogens;Mus;new therapeutic target;Non-Insulin-Dependent Diabetes Mellitus;Nucleic Acids;Obese Mice;obese patients;obese person;Obesity;Ontology;Operative Surgical Procedures;Pathogenesis;Patients;Pattern;Plasma;Play;protein expression;Proteins;Proteomics;Publishing;Quantitative Reverse Transcriptase PCR;restoration;Risk;Risk Factors;RNA;Role;Sample Size;Sampling;Sampling Studies;sex;Shotguns;Source;Thinness;Tissue Sample;Tissues;Transcript;Validation;verification and validation;Vesicle;Visceral;Work

PROJECT_TITLE: Profiling extracellular vesicle cargo in obesity and type 2 diabetes

STUDY_SECTION: KNOD

STUDY_SECTION_NAME: Kidney, Nutrition, Obesity and Diabetes Study Section[KNOD]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Digestive Diseases;Genetics;Microbiome

ORG_CITY: GAINESVILLE

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Project Narrative: RORgt+ lymphocytes (gdT17 cells and ILC3s) play an important role in infection/inflammation and mitochondrial control of immunity beyond ATP generation has emerged as a new concept. The proposed experiments will provide novel insights into the molecular mechanisms of action of mitochondrial transcription factor A (Tfam), a key factor for mitochondrial respiration, in regulation of RORgt+ cell maintenance and function and its role in regulation of small intestine tissue remodeling, infection and inflammation. Better understanding of RORgt+ lymphocyte biology regulated by Tfam may eventually provide novel means to treat human disease (e.g., helminth infection and inflammatory bowel disease).

PI_NAMEs: ZHOU, LIANG  (contact)

PROGRAM_OFFICER_NAME: HUDSPETH, KELLY

PROJECT_TERMS: Ablation;Adoptive Transfer;Affect;Anabolism;Anaerobic Bacteria;Antibiotic Therapy;Cell Compartmentation;Cell Differentiation process;Cell Maintenance;Cell Physiology;Cell Proliferation;Cells;Cellular Metabolic Process;Coculture Techniques;cytokine;Data;Development;Disease;DNA biosynthesis;Effector Cell;enteric infection;Environment;Epigenetic Process;Epithelial Cells;Exhibits;experimental study;factor A;gastrointestinal epithelium;Generations;Genetic;Genetic Transcription;glucose metabolism;Glycolysis;gut microbiome;helminth infection;Helper-Inducer T-Lymphocyte;Histologic;Homeostasis;human disease;IL17 gene;IL18 gene;Immune;immune function;Immunity;In Vitro;in vivo;Individual;Infection;Inflammation;Inflammatory Bowel Diseases;insight;Interleukin-13;interleukin-22;intestinal homeostasis;intestinal injury;Length;Lymphocyte;Lymphocyte Biology;Lymphocyte Function;Lymphoid Cell;Maintenance;Mediating;Metabolic;Metabolism;Metronidazole;microbiome;Mitochondria;Mitochondrial DNA;mitochondrial metabolism;Modeling;Molecular;Molecular Mechanisms of Action;mtTF1 transcription factor;Mus;Mutant Strains Mice;novel;novel therapeutics;Orphan;Oxidative Phosphorylation;Paper;Pathogenesis;Phenocopy;Phenotype;Play;Population;prevent;Prevention;Production;programs;Proliferating;Protozoa;Reactive Oxygen Species;receptor;Regulation;Respiration;Retinoic Acid Receptor;Role;Small Intestines;System;T-Lymphocyte;Tissues;transcription factor;transcriptome;Tritrichomonas

PROJECT_TITLE: Role of RORgt+ (note: g: is gamma symbol) lymphocytes in Gut Tissue Homeostasis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIB-E(91)]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences

ORG_CITY: IRVINE

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

ORG_STATE: CA

PHR: Project Narrative The successful completion of this project will lead to insights into molecular pathways that cause trabecular meshwork dysfunction and elevation of intraocular pressure in glaucoma, a leading cause of irreversible vision loss. The results will provide pathological mechanisms involved in glaucoma and develop novel treatment strategies for glaucoma by targeting these pathologies.

PI_NAMEs: ZODE, GULAB  (contact)

PROGRAM_OFFICER_NAME: SONG, HONGMAN

PROJECT_TERMS: Autophagocytosis;Autopsy;Biological Assay;Blindness;Cell Death;Cell model;Cell Physiology;Cells;Cessation of life;Chronic;Communication;Deposition;Disease;Endoplasmic Reticulum;endoplasmic reticulum stress;Enhancers;Exhibits;Extracellular Matrix;Eye;Eyedrops;Fibrosis;Functional disorder;Funding;Genetic;Genus Hippocampus;Glaucoma;Glucocorticoids;Goals;Health;Homeostasis;Human;Impairment;improved;In Vitro;in vivo;in vivo Model;insight;Link;Lysosomes;Membrane;Metformin;Mitochondria;mitochondrial dysfunction;Molecular;mouse model;Mus;Nerve Degeneration;Normal tissue morphology;novel;Ocular Hypertension;Organelles;Pathologic;Pathology;Pathway interactions;pharmacologic;Physiologic Intraocular Pressure;Play;prevent;Primary Open Angle Glaucoma;Proteins;Reactive Oxygen Species;Reporter;Role;Stress;Time;Tissues;Trabecular meshwork structure;transcription factor;Transforming Growth Factor beta;Transmission Electron Microscopy;treatment strategy;Work

PROJECT_TITLE: Crosstalk between chronic ER stress and mitophagy for the treatment of POAG

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 1 Study Section[PED1]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Cardiovascular;Genetics;Heart Disease;Pediatric;Pediatric Cardiomyopathy;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE Hypertrophic cardiomyopathy (HCM) is a genetic heart disease that leads to thickening of the heart muscle, ultimately reducing cardiac function and potentially inducing sudden cardiac death in young adults. Almost 50% of HCM-linked, pathogenic mutations occur in the sarcomeric protein cardiac myosin binding protein C (cMyBP- C), however, the mechanism by which cMyBP-C mutations lead to HCM is largely unknown, limiting the development of targeted therapeutics that could treat the underlying effects of the mutation instead of simply lessening the symptoms. To address this, this project aims to study both the structure-function and energetic pathophysiological mechanisms that underly a highly penetrant HCM-inducing mutation in cMyBP-C utilizing HCM patient derived cardiomyocytes.

PI_NAMEs: STECZINA, SONETTE  (contact)

PROGRAM_OFFICER_NAME: WOO, SEUNG KYOON

PROJECT_TERMS: 3-Dimensional;Acceleration;Actins;Address;Affect;Age of Onset;Back;Binding;Biochemistry;Biological Assay;cardiac muscle disease;Cardiac Myocytes;Cardiac Myosins;cardiac tissue engineering;Cell Line;Cells;citrate carrier;Clinical;cohort;cost;CRISPR/Cas technology;Custom;Data;Development;Disease;Disease Progression;Evaluation;Extracellular Matrix;Fibrin;Founder Effect;Functional disorder;Gender;Generations;Genetic;genetic variant;Genus Hippocampus;Heart Diseases;Heart failure;heart function;Heart Transplantation;Hypertrophic Cardiomyopathy;individualized medicine;Induced Mutation;induced pluripotent stem cell;Inherited;insight;Italy;Kinetics;Lead;Left;Length;Link;liquid chromatography mass spectrometry;Mass Spectrum Analysis;metabolic profile;Metabolism;metabolomics;Missense Mutation;Modality;Modeling;mutant;Mutation;mutation correction;Myocardium;Myofibrils;Myosin ATPase;myosin-binding protein C;Obstruction;Operative Surgical Procedures;Pathogenicity;Pathologic;patient derived induced pluripotent stem cells;Patients;Pattern;Phenotype;Phosphocreatine;pluripotent stem cell differentiation;pre-clinical;Prevalence;Production;protein expression;protein protein interaction;Proteins;Proteomics;Quality of life;recruit;Relaxation;Respiration;Sampling;Sarcomeres;screening;stoichiometry;Structure;sudden cardiac death;Surface;symptom management;Symptoms;targeted treatment;Testing;Therapeutic;Thick Filament;Thrombin;Tissue constructs;Tissues;University Hospitals;Variant;Ventricular;young adult

PROJECT_TITLE: Mechanisms of cardiomyocyte dysfunction due to the E258K-MYBPC3 mutation modeled in patient-derived cardiomyocytes


ED_INST_TYPE: GRADUATE SCHOOLS

ORG_NAME: ROCKEFELLER UNIVERSITY

PHR: Project Narrative Immunosuppression within patient tumors poses a critical challenge that limits the breadth and efficacy of cancer  immunotherapies designed to establish antitumor immunity. Delivery of molecular signals that activate innate  immunity is a powerful strategy to transform tumors to an immunoactivated state and stimulate cytotoxic T-cell  responses that control tumor growth. This research proposal will leverage a new family of immune signaling  proteins to discover novel molecules for stimulating antitumor immunity in human cancers.

PI_NAMEs: SLAVIK, KAILEY  (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: Address;Agonist;Animals;anti-tumor immune response;Antigen Presentation;Antigen-Presenting Cells;Antitumor Response;Bacteria;Bacteriophages;Biochemical;Biochemistry;Biology;Cancer Control;cancer immunotherapy;Cell Culture Techniques;Cells;Chemicals;Clinical;Cross-Priming;Cyclic GMP;Cytotoxic T-Lymphocytes;Data;design;Detection;Development;Dinucleoside Phosphates;Dissection;DNA;Double-Stranded RNA;Drosophila genus;ds-DNA;Enzymes;Escherichia coli;Exhibits;experimental study;extracellular;Family;Family member;fly;Gene Activation;Gene Silencing;Homologous Gene;Human;Immune;Immune response;Immune signaling;Immune system;Immunity;Immunologics;Immunosuppression;Immunotherapy;improved;In Vitro;in vivo;Infiltration;Inflammatory;innate immune pathways;Isomerism;Knowledge;Ligand Binding;Ligands;Malignant Neoplasms;Modeling;Molecular;Names;Natural Immunity;Nature;neoplastic cell;novel;novel strategies;nucleotide metabolism;nucleotide receptor;Nucleotides;pathogen;Pathway interactions;Patients;Pattern;Periodicity;Phagocytes;Phase;Postdoctoral Fellow;Predisposition;Protein Family;Proteins;receptor;receptor function;Receptor Signaling;recruit;Research;Research Project Grants;Research Proposals;response;RNA;Role;screening;Second Messenger Systems;sensor;Signal Induction;Signal Pathway;Signal Transduction;Signaling Protein;Stimulator of Interferon Genes;structural biology;Structure;success;Surface;T cell response;Techniques;Therapeutic;tool;tumor;tumor growth;Tumor Immunity;tumor microenvironment;Tumor-Derived;vector;Viral;Virus Diseases;Work

PROJECT_TITLE: Discovery of diverse nucleotide immune signals for use as novel immunotherapies


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Disorders;Genetics;Human Genome;Mental Health;Mental Illness;Schizophrenia;Serious Mental Illness

ORG_CITY: CAMBRIDGE

ORG_NAME: BROAD INSTITUTE, INC.

PHR: We will develop new statistical methods for the analysis of common and rare variant genetic data, in order to boost power to detect association and interpret the biological consequences of genetic variation. We will apply these methods across massive genetic datasets of psychiatric disease including genome-wide association, whole exome sequencing and whole genome sequencing. We will make these methods freely available in open source tools such as Hail.

PI_NAMEs: NEALE, BENJAMIN MICHAEL (contact)

PROGRAM_OFFICER_NAME: PEVSNER, JONATHAN ABRAM

PROJECT_TERMS: Area;Attention deficit hyperactivity disorder;autism spectrum disorder;Binding;biobank;Biological;Biological Process;Bipolar Disorder;Chromatin;Collaborations;Communities;Complex;Computer software;Data;Data Set;Disease;disorder risk;diverse data;Ensure;epigenomics;exome sequencing;Frequencies;Gene Expression Regulation;Genes;Genetic;Genetic study;genetic variant;Genetic Variation;genome sequencing;genome wide association study;genome-wide;Genotype;Growth;Haplotypes;Heritability;human disease;Human Genome;Individual;insight;Learning;Localized Disease;Major Depressive Disorder;Maps;Mental disorders;Methods;next generation;novel;open source;open source tool;Population;Positioning Attribute;programs;psychiatric genomics;Psychopathology;Publications;rare variant;Research;Risk;Sampling;Schizophrenia;Statistical Methods;statistics;Technology;Tissues;trait;Trans-Omics for Precision Medicine;transcription factor;Variant;whole genome;Work

PROJECT_TITLE: Statistical methods to localize disease heritability and identify biological mechanisms

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cardiovascular;Clinical Research;Data Science;Duchenne/ Becker Muscular Dystrophy;Heart Disease;Machine Learning and Artificial Intelligence;Muscular Dystrophy;Networking and Information Technology R&D (NITRD);Orphan Drug;Pediatric;Pediatric Cardiomyopathy;Precision Medicine;Prevention;Rare Diseases

ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: PROJECT NARRATIVE Duchenne muscular dystrophy (DMD) is a devastating disease with no cure. Early identification of heart disease onset and progression in DMD patients using novel imaging biomarkers and deep learning will help to improve length and quality of life in this vulnerable population. The imaging biomarkers and methods developed in this project may also play a crucial role in stratifying patients for future clinical trials and research to improve outcomes and responses to therapy.

PI_NAMEs: EARL, CONNER  (contact)

PROGRAM_OFFICER_NAME: CHEON, YEWON

PROJECT_TERMS: 3-Dimensional;4D Imaging;Address;Affect;Age of Onset;algorithm development;Area;Artificial Intelligence;automated analysis;automated segmentation;Award;Biological Markers;biomarker development;Biomechanics;Biomedical Engineering;Birth;boys;Cardiac;cardiac magnetic resonance imaging;Cardiomyopathies;cardiovascular imaging;Cause of Death;Childhood;Clinical;clinical center;Clinical Research;Clinical Treatment;Clinical Trials;Collaborations;Computer Analysis;convolutional neural network;Data;data registry;Data Science;Data Set;Databases;deep learning;deep learning algorithm;deep neural network;Diagnostic;Disease;Disease Progression;Doctor of Philosophy;Duchenne cardiomyopathy;Duchenne muscular dystrophy;Early Diagnosis;Early identification;early onset;Early treatment;Engineering;Evaluation;Fellowship;frontier;Future;Genetic Diseases;Heart;Heart Diseases;heart function;heart imaging;Image;Image Analysis;imaging biomarker;imaging modality;improved;improved outcome;Incidence;Indiana;Individual;innovation;insight;Institution;kinematics;Kinetics;Left;Length;Link;Longevity;male;Maps;Measures;Medical;medical schools;Medicine;Mentorship;Methods;mortality;Muscle Weakness;National Heart, Lung, and Blood Institute;Neuromuscular Diseases;novel;novel diagnostics;novel therapeutic intervention;Onset of illness;Outcome Measure;patient population;patient stratification;Patient-Focused Outcomes;Patients;Pattern;pediatric cardiologist;Pediatric cardiology;Pediatric Hospitals;Phenotype;Physicians;Physiology;Play;Population;Population Study;predictive marker;Predisposition;prevent;Prognosis;Protocols documentation;Quality of life;Registries;repository;Research;Risk;risk prediction;risk stratification;Role;Scientist;skills;spatiotemporal;Standardization;Symptoms;Techniques;Teenagers;Time;Training;training data;treatment response;Universities;Ventricular;Vulnerable Populations;Work

PROJECT_TITLE: Spatiotemporal and Deep Learning Analysis of Cardiac Imaging for Predictive Risk Stratification in Duchenne Muscular Dystrophy


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Networking and Information Technology R&D (NITRD)

ORG_CITY: PHILADELPHIA

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Narrative Advanced Normalization Tools (ANTs) is freely available software that provides image registration, segmentation, and other basic biomedical image processing and analysis functionality. ANTs has contributed to thousands of published studies spanning many areas of research, including in key public health areas such as cancer and heart, lung, and brain disease. This project will ensure that ANTs is available to basic scientists and clinical researchers in the future, as well as implement innovations that will allow even more investigators to take advantage of the tool's capabilities in their scientific work.

PI_NAMEs: GEE, JAMES C (contact)

PROGRAM_OFFICER_NAME: DUAN, QI

PROJECT_TERMS: 3-Dimensional;Acceleration;Algorithms;Animals;Area;Audience Research;biomedical imaging;Biomedical Research;Body System;Brain;Brain Diseases;Cardiovascular system;Clinical;clinical application;cluster computing;Collaborations;Communities;Complement;Complex;computational platform;Computer software;Computers;Data;Data Set;Dedications;deep learning;Detection;Development;Documentation;Ecosystem;Educational workshop;Ensure;Exhibits;experience;feature detection;Feedback;Funding;Future;Heart Diseases;High Performance Computing;Human;Image;Image Analysis;image processing;image registration;imaging modality;Imaging technology;improved;Industrialization;Infrastructure;innovation;insight;interest;interoperability;Journals;large datasets;Libraries;Literature;Lung;Lung Diseases;Magnetic Resonance Imaging;Malignant Neoplasms;Maps;Measures;Medical Imaging;meetings;member;Memory;Methodology;Microscopy;Modality;Modernization;multimodality;neural network;next generation;novel strategies;open source;open source library;Organism;Output;outreach;parallel processing;Pattern;Performance;Programming Languages;Protocols documentation;Public Health;Publishing;Qualitative Evaluations;quantitative imaging;Recording of previous events;Regional Anatomy;Reproducibility;Research;Research Personnel;research study;Resolution;Resources;respiratory;Sampling Studies;Science;Scientist;Source;Source Code;Statistical Study;success;support tools;Technology;Time;tool;tool development;Training;United States National Institutes of Health;Update;Validation;Work

PROJECT_TITLE: Advanced Normalization Tools

STUDY_SECTION: ITD

STUDY_SECTION_NAME: Imaging Technology Development Study Section[ITD]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Orphan Drug;Rare Diseases

ORG_CITY: MENANDS

ORG_NAME: WADSWORTH CENTER

PHR: Project Narrative Macrolides and aminoglycosides comprise the frontline treatment against M. abscessus. However induction of resistance pathways either by exposure to the drugs or the host environment result in a poor treatment efficacy. In this proposal we will undertake an in- depth structure-function characterization of two novel resistance pathways involving the ribosome associated proteins- HflX and ABCFs. This work will also provide the first demonstration of changes in bacteria within the host environment that result in increased resistance to aminoglycosides.

PI_NAMEs: GHOSH, PALLAVI  (contact)

PROJECT_TERMS: Amikacin;Aminoglycoside resistance;Aminoglycosides;Antibiotic Resistance;Antibiotic susceptibility;Antibiotics;Bacteria;Binding;Binding Proteins;Biochemical;Cefoxitin;Chronic;Collaborations;Cryoelectron Microscopy;Development;Dissociation;Drug resistance;drug sensitivity;Environment;Exhibits;Exposure to;Genetic;Genomics;Guanosine Triphosphate Phosphohydrolases;Hibernation;Imipenem;In Vitro;in vivo;Infection;Infectious Skin Diseases;Injectable;Intervention;lincosamide;Lung infections;lung injury;Macrolides;Mediating;Messenger RNA;Microbial Antibiotic Resistance;Modeling;Molecular;mutant;mycobacterial;Mycobacterium abscessus;Mycobacterium smegmatis;Mycobacterium tuberculosis;novel;novel therapeutic intervention;Oral;pathogen;Pathogenicity;Pathway interactions;Patients;Pharmaceutical Preparations;Population;Proteins;Recycling;Regimen;Resistance;resistance mechanism;response;Ribosomes;Role;Site;Soft Tissue Infections;Starvation;Structure;therapeutically effective;tigecycline;Tissues;Treatment Efficacy;Work;Y protein;Zinc;Zinc deficiency

PROJECT_TITLE: Role of ribosome modulating proteins in conferring Mycobacterium abscessus antibiotic resistance

STUDY_SECTION: DDR

STUDY_SECTION_NAME: Drug Discovery and Mechanisms of Antimicrobial Resistance Study Section[DDR]


NIH_SPENDING_CATS: Genetics;HIV/AIDS;Infectious Diseases;Mental Health;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Umbilical Cord Blood/ Placenta;Stem Cell Research - Umbilical Cord Blood/ Placenta - Human

ORG_CITY: FAIRFAX

ORG_NAME: GEORGE MASON UNIVERSITY

PHR: Project Narrative- Relevance This project will develop and characterize a highly innovative modular approach that will utilize extracellular vesicles to deliver anti-HIV genes to virus infected cells and epigenetically silence HIV expression in a long term and stable manner. This method may also lead to a therapeutically relevant means to not only control HIV/HAND but also usher in a new highly innovative methodology that could be used to control the epigenetic state of those genes involved in various other human diseases.

PI_NAMEs: KASHANCHI, FATAH  (contact)

PROGRAM_OFFICER_NAME: RAO, VASUDEV RAMACHANDRA

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Adherence;Anti-Retroviral Agents;antiretroviral therapy;Astrocytes;Blood Vessels;Brain;CCR5 gene;CD34 gene;Cell Line;Cell model;Cells;Central Nervous System;cost;CXCR4 Receptors;Death Rate;Disease;DNA Methylation;Drug resistance;Drug Targeting;Engineering;Enzymes;Epigenetic Process;epigenetic regulation;epigenetic silencing;extracellular vesicles;Generations;Genes;Genetic Transcription;Genome;Highly Active Antiretroviral Therapy;HIV;HIV Envelope Protein gp120;HIV Infections;HIV-1;Human;human disease;Immune;Immune system;improved;In Vitro;in vivo;Individual;induced pluripotent stem cell;Infection;innovation;Intravenous;Lentivirus;Life Expectancy;Macrophage;Mediating;Meningeal;Methodology;Methods;Microglia;Modality;monocyte;Morbidity - disease rate;mouse model;Mus;nerve stem cell;neuroAIDS;Neurosphere;novel;Opportunistic Infections;particle;Pathway interactions;Patients;Persons;Pharmacotherapy;promoter;Provirus Integration;Proviruses;receptor;Recombinants;Repression;RNA;Shock;side effect;Site;small hairpin RNA;Techniques;Testing;Therapeutic;therapeutic RNA;Viral;Virus;Virus Diseases;Zinc Fingers

PROJECT_TITLE: Cell-derived extracellular vesicle mediated epigenetic silencing of HIV in the brain


NIH_SPENDING_CATS: Genetics;HIV/AIDS;Infectious Diseases

ORG_CITY: CORAL GABLES

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE: HIV-1 can persist in T cells and macrophages but there are few strategies being explored to eliminate infected macrophages. The proposed studies are based on our preliminary observations that HIV-1 activity can be irreversibly blocked by chemicals that suppress cellular gene expression. We will explore the mechanism by which these inhibitors block HIV so as to pave the way for a novel strategy to block the persistence of HIV-1 in some anatomic compartments of HIV-1 infected individuals.

PI_NAMEs: STEVENSON, MARIO  (contact)

PROGRAM_OFFICER_NAME: SHANKAR, UDAY K

PROJECT_TERMS: Alveolar Macrophages;Anatomy;antagonist;Attention;Binding;cancer therapy;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cell Compartmentation;cell killing;Cell Physiology;Cells;Central Nervous System;Chemicals;Clinical;Competence;cytokine;cytotoxic CD8 T cells;Development;Dominant-Negative Mutation;Epigenetic Process;epigenetic silencing;Excision;Exhibits;experimental analysis;experimental study;Gene Expression;Genetic Transcription;heterokaryon;HIV;HIV-1;HIV/AIDS;I-kappa B Proteins;in vivo;Individual;induced pluripotent stem cell;Infection;inhibitor;Interruption;Kupffer Cells;Link;Liver;Lung;Macaca;Macrophage;Mediating;Methods;Methylation;Microglia;Modeling;Modification;molecular clock;monocyte;Myelogenous;Myeloid Cells;Natural Killer Cells;NF-kappa B;novel;novel strategies;Phagocytes;pharmacologic;Phylogenetic Analysis;Physiological;Plasma;Population;Process;Production;Proviruses;Refractory;Research;resilience;Sampling;simian human immunodeficiency virus;T-Lymphocyte;Therapeutic;Viral;Viral reservoir;Viremia;Virion;Virus;Virus Activation;Virus Latency;Virus Replication

PROJECT_TITLE: Irreversible Proviral Silencing in Myeloid Cells


NIH_SPENDING_CATS: Bioengineering;Eye Disease and Disorders of Vision;Neurosciences;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: ROCHESTER

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: Narrative:  Vision loss exacts an enormous toll on individuals and on society, and progress has been slow in developing therapies for restoring vision in the blind. To greatly reduce the time required to develop effective cures for blindness, we have a new way of imaging the retina that can provide information about whether retinal cells benefit from new therapeutic approaches. This novel functional imaging technique will be applied to evaluate photoreceptor replacement therapy in the fovea, the area of the retina that mediates high quality vision. Success in restoring vision at this location will provide strong evidence that this type of therapy could restore usable vision in patients and regenerative therapies should move rapidly into clinical trials.

PI_NAMEs: MCGREGOR, JULIETTE ELIZABETH (contact)

PROGRAM_OFFICER_NAME: LEE, PAEK-GYU

PROJECT_TERMS: 3-Dimensional;Ablation;Acceleration;adaptive optics;Adult;Anatomy;Area;Automobile Driving;Behavior;biodegradable scaffold;blind;Blindness;Calcium;calcium indicator;California;Cell Physiology;Cell Therapy;Cells;cellular imaging;Clinical Trials;Collaborations;Cone;Custom;Data;density;Development;efficacy evaluation;Evaluation;Eye;Family suidae;Fluorescence;fovea centralis;Functional Imaging;functional restoration;Funding;fundus imaging;Future;Generations;Histology;Human;human pluripotent stem cell;Hyperactivity;Image;imaging approach;imaging system;Imaging Techniques;Immune system;Immunoelectron Microscopy;Implant;improved;in vivo;in vivo calcium imaging;in vivo evaluation;in vivo imaging;Individual;Intervention;Lasers;Light;Location;Mediating;Methods;Modeling;Noise;novel;novel therapeutic intervention;Operative Surgical Procedures;Ophthalmoscopy;Optics;Patients;Photophobia;Photoreceptors;Physiologic pulse;Physiology;Population;pre-clinical;preclinical evaluation;Preclinical Testing;preservation;prevent;Primates;regeneration potential;regenerative therapy;Replacement Therapy;Resolution;response;Retina;Retinal Degeneration;Retinal Ganglion Cells;retinal imaging;Rodent;scaffold;Scanning;Side;sight restoration;Signal Transduction;Societies;Speed;stem cells;Structure;success;Synapses;synaptogenesis;System;Technology;Testing;Therapeutic Intervention;therapy development;Time;Transplantation;Transplantation Surgery;Tretinoin;ultra high resolution;Universities;usability;Variant;virtual;Vision;Visual System;Wisconsin

PROJECT_TITLE: Accelerating photoreceptor replacement therapy with in-vivo cellular imaging of retinal function


PHR: Project Narrative Pulmonary Arterial Hypertension (PAH) is a severe and progressive disease with a high mortality rate. These studies may uncover previously unknown roles for the mitochondria in the initiation and progression of PAH. Importantly, this work may identify novel targets for therapeutic intervention to improve the quality of life and lifespan of PAH patients.

PI_NAMEs: LOCKETT, ANGELIA DENISE (contact)

PROGRAM_OFFICER_NAME: SUTLIFF, ROY L

PROJECT_TERMS: Apoptosis;Blood Vessels;Caenorhabditis elegans;cancer cell;career;Cell Hypoxia;Cell Physiology;Cell Proliferation;Cell Survival;Cells;Cessation of life;Death Rate;Development;Endothelial Cells;Endothelium;Goals;Human;Hypoxia;Impairment;improved;in vivo;Inhibition of Apoptosis;Intervention;Knowledge;Laboratories;life span;Lung;Lung Diseases;Mediating;Mediator;Mitochondria;mitochondrial dysfunction;Molecular;Motility;new therapeutic target;novel;Outer Mitochondrial Membrane;Pathogenesis;Pathologic;Pathway interactions;Patients;Pharmacologic Substance;Phenotype;Phosphorylation;Phosphotransferases;Process;Prognosis;Progressive Disease;Proliferating;Proteins;pulmonary arterial hypertension;pulmonary artery endothelial cell;Pulmonary artery structure;Pulmonary Hypertension;pulmonary vascular cell proliferation;pulmonary vascular cells;pulmonary vascular remodeling;Pulmonary Vascular Resistance;Quality of life;Regulation;Research;Research Personnel;Resistance;Respiration;response;right ventricular failure;Rodent;Rodent Model;Role;Signal Transduction;skills;Smooth Muscle Myocytes;Sphingolipids;Sphingosine;sphingosine 1-phosphate;SPHK1 enzyme;targeted treatment;tenure track;Testing;Therapeutic Intervention;Training Programs;vascular abnormality;Vascular remodeling;Vascular resistance;Vasodilation;Work

PROJECT_TITLE: Regulation of UPRmt activation in the development of pulmonary vascular remodeling in PAH


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Infectious Diseases;Lung;Rare Diseases;Tuberculosis

ORG_DEPT: MISCELLANEOUS

PHR: PROJECT NARRATIVE We have identified unique macrophage responses in humans who naturally resist Mycobacterium tuberculosis (Mtb) infection despite heavy exposure. The aims of this proposal are to uncover proteomic determinants of this macrophage resistance and define the underlying cellular mechanisms and Mtb-host protein interactions. Once key protective pathways are identified, they can be augmented with targeted host-directed therapies that improve killing of drug-sensitive and drug-resistant Mtb.

PI_NAMEs: ANTERASIAN, CHRISTINE M (contact)

PROGRAM_OFFICER_NAME: MENDEZ, SUSANA

PROJECT_TERMS: Address;Advisory Committees;AGFG1 gene;Autophagocytosis;Award;Bacterial Proteins;Bioinformatics;bioinformatics network;Biological Assay;candidate identification;career development;Cellular Immunology;Childhood;Classification;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;Communicable Diseases;cytokine;Data;data integration;Data Set;design;detection method;Development;Drug resistant Mycobacteria Tuberculosis;drug-sensitive;Ensure;experimental study;Exposure to;Family;Funding;Genes;Genetic;Genetic Polymorphism;Genetic Transcription;Goals;Growth;Guanosine Triphosphate Phosphohydrolases;Host Defense;Household;Human;Human Subject Research;Immune response;improved;Individual;induced pluripotent stem cell;Infection;insight;Interferon Type II;International;Knowledge;Laboratories;large datasets;leukocyte activation;Longitudinal Studies;Macrophage;Macrophage Activation;Mass Spectrum Analysis;Mediating;meetings;Membrane;Mentors;Mentorship;mRNA Expression;Mycobacterium tuberculosis;Natural Resistance;novel;Outcome;Pathway Analysis;Pathway interactions;Patients;Pediatric Hospitals;Persons;Phenotype;Post-Translational Protein Processing;Process;Program Development;protective pathway;protein function;Proteins;Proteome;Proteomics;Pulmonary Tuberculosis;Quantitative Microscopy;rab GTP-Binding Proteins;Regulation;Research Personnel;Resistance;resistance mechanism;response;Role;Structure;Systems Biology;Techniques;Therapeutic;trafficking;Training;transcriptomics;Tuberculin Test;Tuberculosis;Ubiquitin;Ubiquitination;Uganda;Universities;Washington;Work;Writing

PROJECT_TITLE: Immunoproteomic mechanisms of human macrophage resistance to Mycobacterium tuberculosis infection

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases Advisory Committee[MID]


NIH_SPENDING_CATS: Bioengineering;Cancer;Digestive Diseases;Nanotechnology;Pancreatic Cancer;Prevention;Rare Diseases

ORG_CITY: NEW ORLEANS

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: NARRATIVE Extracellular vesicles (EVs) hold great promise as biomarkers for minimally-invasive disease detection, but most current EV analysis methods are low-throughput and require EV pre-isolation steps, which can greatly decrease their reproducibility, and are impractical for clinical use. To address this problem, we have developed a rapid, robust, and isolation-free nanoparticle-based EV assay that directly quantitates tumor-derived EVs in serum or plasma samples to diagnose pancreatic cancer (PC), including early disease, with high reproducibility, sensitivity and specificity. This proposal is designed to automate and further improve the accuracy and reproducibility of our novel assay with a single vesicle resultion for PC diagnosis, and perform analytical validation of this assay according to Clinical and Laboratory Standards Institute guidelines in CLIA- certified laboratory.

PI_NAMEs: HU, TONY Y. (contact);LU, HUA ;SEN, SUBRATA

PROGRAM_OFFICER_NAME: GRODZINSKI, PIOTR

PROJECT_TERMS: Address;advanced disease;Affect;antibody detection;Benign;Binding;Biological Assay;Biological Markers;Blood specimen;CA-19-9 Antigen;Cancer Detection;cancer diagnosis;cancer initiation;cancer stem cell;cancer therapy;candidate validation;CD44 gene;Cells;Circulation;CLIA certified;Clinical;clinical translation;cohort;Complex;design;Detection;detection assay;Development;Diagnosis;Diagnostic;digital;Disease;disorder control;Early Diagnosis;early screening;Early treatment;Excision;Exhibits;extracellular vesicles;fabrication;Family history of;Guidelines;human disease;human model;Image;improved;improved outcome;Individual;Inherited;Laboratories;Lesion;longitudinal analysis;Longitudinal Studies;Malignant - descriptor;Malignant neoplasm of pancreas;Malignant Neoplasms;Manuals;Methods;Microfabrication;minimally invasive;Modeling;Monitor;mouse model;Mus;nanoparticle;nanoplasmonic;Neoadjuvant Therapy;Neoplasm Metastasis;Non-Malignant;novel;novel marker;Operative Surgical Procedures;Pancreas;pancreatic cancer model;pancreatic cancer patients;Pancreatitis;Patients;Performance;Pilot Projects;Plasma;pre-clinical;Predictive Cancer Model;premalignant;Procedures;Proteins;Protocols documentation;Reader;Reagent;Regimen;Reporting;Reproducibility;Research;Resectable;Resistance;Resolution;response;sample collection;Sampling;Sensitivity and Specificity;Serum;Source;Specificity;success;Surface;Syndrome;TACSTD1 gene;Therapeutic;Time;translational impact;Treatment outcome;treatment response;tumor;tumor initiation;Tumor stage;Tumor-Derived;Urine;Validation;Variant;Vesicle;Work

PROJECT_TITLE: Digital Nanoplasmonic Quantification of Tumor-derived Extracellular Vesicles in Plasma Microsamples


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: BUFFALO

ORG_NAME: ROSWELL PARK CANCER INSTITUTE CORP

ORG_STATE: NY

PHR: Narrative – Roswell Park Ovarian Cancer SPORE The Roswell Park Ovarian Cancer SPORE brings together laboratory and clinical investigators with the collective focus to tackle some of the most important translational research challenges in ovarian cancer. The three Individual Research Projects focus on innovative approaches to generate effective anti-tumor immunity and overcome multiple mechanisms of tumor immune escape. Our SPORE fosters the recruitment of new ideas and investigators through the Career Enhancement Program and Developmental Research Program, promotes the integrated utilization of four shared resource cores, and encourages active engagement of patient advocates.

PI_NAMEs: MOYSICH, KIRSTEN B. (contact);ODUNSI, KUNLE

PROGRAM_OFFICER_NAME: BASA JANAKIRAM, NAVEENA

PROJECT_TERMS: Address;Advocate;antagonist;anti-cancer research;Award;Basic Science;Bioinformatics;Biological Markers;Biometry;Bypass;cancer cell;Cancer Patient;Cancer Research Project;career;CD8-Positive T-Lymphocytes;CD8B1 gene;Cessation of life;Clinical;Clinical Investigator;clinical practice;Clinical Research;Clinical Trials;Collaborations;Communities;CTAG1 gene;CXCR4 gene;Data;Dendritic Cells;Development;Discipline;Disease;disorder control;engineered T cells;Engineering;Ensure;Environment;Epithelial ovarian cancer;exhaustion;Extramural Activities;first-in-human;Fostering;Funding;Future;Genes;Goals;high risk;Human;Immune;immune checkpoint blockade;Immune mediated destruction;immune resistance;Immune response;Immune system;Immunogenomics;Immunologics;Immunosuppression;Immunotherapy;improved;improved outcome;in vivo;Incubators;Individual;Infiltration;innovation;innovative technologies;Institution;inter-institutional;interest;Investigation;Laboratories;Macrophage;Malignant neoplasm of ovary;Mentors;multidisciplinary;Myeloid-derived suppressor cells;Nature;novel;novel marker;novel strategies;Oncolytic viruses;organizational structure;Outcome;ovarian neoplasm;Pathology;patient engagement;Patient Participation;Patient-Focused Outcomes;Patients;PD-L1 blockade;Phase I/II Clinical Trial;Pilot Projects;Play;pre-clinical;Prevention;Productivity;Prognosis;programs;Property;proteogenomics;Randomized;recruit;Recurrence;Research;Research Personnel;Research Project Grants;resistance mechanism;Resource Sharing;Resources;response;Role;Scientist;success;Surgical Management;T cell therapy;T-Lymphocyte;Testing;Therapeutic;therapeutic effectiveness;Transforming Growth Factor beta;translational cancer research;translational impact;translational potential;Translational Research;translational research program;translational study;Translations;tumor;Tumor Antigens;Tumor Escape;Tumor Immunity;Tumor Tissue;Tumor-infiltrating immune cells;Vaccination;Woman

PROJECT_TITLE: Roswell Park Ovarian Cancer SPORE


NIH_SPENDING_CATS: Cancer;Ovarian Cancer;Patient Safety;Rare Diseases;Women's Health Research

PHR: NARRATIVE The Administration Core will serve the Roswell Park Ovarian Cancer SPORE's overall translational research objectives by providing effective leadership and administrative support for a broad range of SPORE-related activities to ensure optimal progress and performance of all leaders, investigators, projects, cores, and developmental programs. The Core's responsibilities include direct support to investigators, planning, coordination and management of all scientific and administrative collaborations with the NCI, other SPOREs, partner institutions, and facilitating interactions and collaborations with the patient and advocate community.

PI_NAMEs: MOYSICH, KIRSTEN B. (contact)

PROJECT_TERMS: Administrative Coordination;Advocate;anti-cancer research;Area;Biotechnology;Budgets;career;Clinical Trials;Collaborations;Committee Members;Communication;Communities;Community Clinical Oncology Program;Comprehensive Cancer Center;cost;Data;Development;Educational workshop;Ensure;Environment;Evaluation;Event;Expenditure;experience;Fostering;Funding;human subject protection;Human Subject Research;Individual;Institution;Leadership;Malignant neoplasm of ovary;Malignant Neoplasms;Manuscripts;meetings;Monitor;National Cancer Institute;Occupational activity of managing finances;Office of Administrative Management;Patients;Performance;Pharmacologic Substance;Policies;Preparation;Productivity;programs;Progress Reports;Publications;quality assurance;Regulation;Report (document);Reporting;Research;Research Personnel;Resources;Risk;Safety;Services;Translational Research;Travel;United States National Institutes of Health;Universities;University of Pittsburgh Cancer Institute;Work

PROJECT_TITLE: Administrative Core


ORG_CITY: SAN FRANCISCO

ORG_NAME: J. DAVID GLADSTONE INSTITUTES

PHR: OVERALL – NARRATIVE This program project will bring together leaders in disease-focused neuroscience, systems biology and bioinformatics to address important problems in Alzheimer’s disease (AD) research that are both unresolved and understudied. The proposed experiments could elucidate molecular and cellular mechanisms of neural network dysfunction and cognitive decline in AD and promote the development of novel therapeutic strategies to block them. Sharing the highly diverse data sets we will generate and disseminating the novel integrative approaches we plan to develop for their analysis could also enhance the progress of many other groups working in AD research or biomedicine in general.

PI_NAMEs: HUANG, YADONG ;MUCKE, LENNART  (contact)

PROGRAM_OFFICER_NAME: GRAY, ERIN EMILY

PROJECT_TERMS: Address;Algorithms;Alzheimer like pathology;Alzheimer's Disease;Alzheimer's disease brain;Amino Acid Sequence;Amino Acid Substitution;Amyloid beta-Protein;Apolipoprotein E;apolipoprotein E-4;Apolipoproteins;Autopsy;Behavior;behavior test;Behavioral;Biochemical;Bioinformatics;Biological Assay;Brain;brain dysfunction;brain tissue;Cell Nucleus;cell type;Cells;Cognitive deficits;cohort;Communities;Complex;Data;data harmonization;Data Science Core;Data Set;Databases;Development;Disease;Disease Progression;diverse data;drug development;Electrophysiology (science);Ensure;epigenomics;epileptiform;Etiology;Experimental Designs;experimental study;familial Alzheimer disease;Functional disorder;Goals;Histopathology;Human;human data;human tissue;Hyperactivity;Impaired cognition;improved;in vivo;Infection;innovation;insight;Interneurons;Intervention;knock-down;Lead;Link;Modeling;Molecular;mouse model;Mus;Nature;network dysfunction;neural network;Neuroglia;neuromechanism;Neurons;neuropathology;neurophysiology;Neurosciences;novel;novel strategies;novel therapeutic intervention;overexpression;Pathogenesis;Pathologic;Pathway interactions;Patients;Phenotype;prevent;programs;Protein Isoforms;Public Health;Research;Research Activity;research and development;Role;Statistical Models;Stress;System;Systems Biology;tau Proteins;Therapeutic;Therapeutic Intervention;transcriptomics;Transgenic Organisms;Validation;Virulence Factors;working group

PROJECT_TITLE: Decoding the Multifactorial Etiology of Neural Network Dysfunction in Alzheimer's Disease


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Ovarian Cancer;Rare Diseases;Women's Health Research

PHR: NARRATIVE The Biospecimen & Pathology Core is instrumental to the overall translational research objective of the Roswell Park Ovarian Cancer SPORE. The Core provides services related to biospecimen collection, processing, distribution and provision of specialized diagnostic and technical histopathology services to SPORE investigators.

PI_NAMEs: MORRISON, CARL D (contact)

PROJECT_TERMS: American;American Society of Clinical Oncology;Archives;automated image analysis;biobank;Biological Assay;Blood specimen;Clinical;Clinical Research;Clinical Trials;Collection;college;Coupled;Cytometry;Data;data dissemination;Diagnostic;digital;digital imaging;DNA methylation profiling;Drug or chemical Tissue Distribution;Eligibility Determination;Evaluation;exome sequencing;experience;Experimental Designs;Guidelines;Histologic;Histology;Histopathology;Human;Human Resources;Image;Immune;Immunogenomics;Immunohistochemistry;immunological status;Immunologics;Individual;Informatics;informatics infrastructure;Infrastructure;interest;Ischemia;laser capture microdissection;Malignant neoplasm of ovary;next generation sequencing;ovarian neoplasm;Pathologic;Pathologist;Pathology;Patient Participation;Patients;Performance;Phenotype;Preparation;Process;Protocols documentation;Qualifying;Quality Control;Research Personnel;Research Project Grants;Research Support;sample fixation;Sampling;Scanning;Services;Site;Slide;Specimen;Standardization;T cell receptor repertoire sequencing;Testing;Tissue Microarray;tissue resource;Tissues;tool;Training;transcriptome sequencing;Translational Research;tumor;tumor microenvironment;Tumor Tissue;Tumor-Infiltrating Lymphocytes

PROJECT_TITLE: Biospecimen and Pathology Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

PI_NAMEs: MUCKE, LENNART  (contact)

PROJECT_TERMS: Accountability;Address;Advisory Committees;Alzheimer's Disease;Applications Grants;Appointment;Bioinformatics;Collaborations;Communities;cost effectiveness;Data;Development;Ensure;Etiology;experience;Faculty;Feedback;Goals;graduate student;Growth;interest;International;Joints;Lead;Leadership;meetings;member;Nervous System Disorder;network dysfunction;neural network;Neurology;Positioning Attribute;Postdoctoral Fellow;Procedures;program dissemination;Program Reviews;programs;Progress Reports;Publications;Reagent;recruit;Research;Research Activity;Research Personnel;Resources;Role;Safety;senior faculty;Services;Surveys;technology development;Training Programs

PROJECT_TITLE: Core A: Administrative Core


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Mental Illness;Neurosciences;Schizophrenia

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE The main goal of the proposal is to develop and test experimentally a computational approach which makes it possible, for the first time and at an unprecedented resolution, to discover functional brain circuits involved in mental disorders, specifically in autism and schizophrenia.

PI_NAMEs: GOGOS, JOSEPH A;VITKUP, DENNIS  (contact)

PROGRAM_OFFICER_NAME: FERNANDEZ, FERNANDO R

PROJECT_TERMS: Affect;Amaze;American;Anatomy;autism spectrum disorder;Behavioral;Biological;Biological Models;Brain;brain cell;Brain imaging;Brain region;cell type;Cognitive;cohort;Collaborations;Collection;Computing Methodologies;connectome data;Data;Development;Disease;Distant;Dreams;Economics;Etiology;Fiber;Foundations;Genetic;genetic analysis;genetic variant;Genome;Genotype;Goals;Grant;Human;human data;Image;insight;Institution;Knowledge;Large-Scale Sequencing;Mediating;Mental disorders;model of autism spectrum disorder;Modeling;mouse model;Mouse Strains;Mus;Mutation;Neuroanatomy;Neurons;neuropsychiatric disorder;Neurosciences;Patients;Phenotype;Photometry;prevent;Productivity;psychogenetics;Publications;rare variant;Recording of previous events;Research;Resolution;Schizophrenia;Sensory;Sex Differences;single-cell RNA sequencing;Site;skills;Social Interaction;Societies;Source;Structure;System;Systems Biology;Testing;Time;ultra high resolution;Universities;Validation;Variant

PROJECT_TITLE: Discovery and analysis of brain circuits and cell types affected in autism and schizophrenia

STUDY_SECTION: MABS

STUDY_SECTION_NAME: Modeling and Analysis of Biological Systems Study Section[MABS]


NIH_SPENDING_CATS: Anorexia;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Dietary Supplements;Eating Disorders;Mental Health;Mental Illness;Neurosciences;Nutrition;Pediatric;Prevention;Serious Mental Illness

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: Narrative Restrictive eating disorders are a debilitating and life-threatening group of psychiatric illness characterized by restricted dietary intake. At present, there are no studies investigating the potential neurobiological impacts dietary restriction may have on the developing brain, particularly white matter, which does not mature until the third decade of life. Using state-of-the-art image processing tools and already collected data, this proposal will generate important and currently unknown information about the interplay between brain development and severe dietary restriction, which may assist in the identification of critical developmental periods of increased vulnerability or optimal periods for clinical interventions.

PI_NAMEs: KUBICKI, MAREK  (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: absorption;Adolescence;Affect;Age;age related changes;aged;Anisotropy;Anorexia Nervosa;Anterior;avoidant restrictive food intake disorder;Blood;Blood specimen;Brain;brain health;career;Cells;Characteristics;Childhood;Clinical;clinical practice;Clinical Research;cohort;connectome;Control Groups;critical developmental period;critical period;Data;data harmonization;Data Set;design;Development;Diagnostic;dietary;Dietary Component;Dietary Factors;Dietary intake;dietary restriction;dietary supplements;Dietitian;Diffusion Magnetic Resonance Imaging;Disease;Eating;Eating Disorders;effectiveness testing;emerging adult;Energy consumption;Energy Intake;Fatty acid glycerol esters;Fatty Acids;Female;Food;Foundations;Future;General Hospitals;Glucose;Goals;Grant;gray matter;Health;Human;Image;image processing;imaging study;improved;in vivo;Individual;individualized medicine;interest;Intervention;Investigation;Iron;Knowledge;knowledge base;Life;Link;Location;Macronutrients Nutrition;Maintenance;Malnutrition;Massachusetts;Measures;medical schools;Mental disorders;Modeling;Myelin;myelination;National Institute of Mental Health;Neurobiology;neuroimaging;novel;Nutritional;Oligodendroglia;Omega-3 Fatty Acids;Parents;Patients;Pattern;Philadelphia;Polyunsaturated Fatty Acids;Population;Premature Mortality;prepuberty;Prevention;Principal Investigator;Process;Production;programs;Psychotic Disorders;Puberty;Records;Reporting;Research;Research Personnel;Research Project Grants;Resources;restrictive eating;Sampling;Schizophrenia;Site;Staging;Structure;Techniques;Testing;Therapeutic Intervention;Time;tool;Vitamin D;Vitamin K;Vitamins;Water;white matter;Work;young adult

PROJECT_TITLE: Evaluating the Impact of Restrictive Eating Disorders on White Matter Development

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Brain Cancer;Brain Disorders;Cancer;Nanotechnology;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: LOS ANGELES

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

PHR: Project Narrative Glioblastoma treatment is frequently inefficient due to the infiltrating nature of these tumors and the inability of current drugs to cross the blood brain barrier (BBB) Therefore, we have developed a multimodal magnetofluorescent nanoplatform that crosses the BBB, delivering chemotherapeutic drug, reducing tumor size and increasing survival.

PI_NAMEs: YU, JOHN S (contact)

PROJECT_TERMS: Anemia;Antineoplastic Agents;Area;Autopsy;Biodistribution;Blood - brain barrier anatomy;blood-brain barrier crossing;Brain;Brain Neoplasms;brain tissue;cancer cell;canine model;Canis familiaris;Carrier Proteins;Cells;Chemotherapy and/or radiation;Cisplatin;Combination Drug Therapy;Contrast Media;cyanine;Disease remission;Drug Delivery Systems;Drug resistance;drug resistance development;Encapsulated;Endothelium;Epithelium;Euthanasia;Excision;FDA approved;ferumoxytol;Future;Glioblastoma;Glioma;Human;image guided;image-guided drug delivery;imaging agent;improved;in vivo;Infiltration;Intracranial Neoplasms;iron oxide nanoparticle;Label;Ligands;Magnetic Resonance Imaging;Magnetism;Malignant - descriptor;Malignant Neoplasms;Mediating;Modeling;mouse model;multimodality;Mus;nanodrug;nanoparticle;nanoprobe;nanotechnology platform;Nature;neoplastic cell;Nude Mice;off-label use;Operative Surgical Procedures;Organic Anion Transporters;overexpression;Paclitaxel;Pathologic;Patients;Pharmaceutical Preparations;polypeptide;preclinical study;preservation;prevent;Property;Radiation therapy;recruit;Recurrence;Recurrent tumor;Resected;Residual Neoplasm;Role;Sampling;Schedule;Serum;small molecule inhibitor;standard of care;statistics;stem cells;superparamagnetism;Survival Rate;Technology;technology platform;temozolomide;Testing;Therapeutic;timeline;Tissues;tumor;Tumor Tissue;uptake

PROJECT_TITLE: Magnetofluorescent nanoplatform for glioblastoma therapy


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biotechnology;Brain Disorders;Data Science;Dementia;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences

PI_NAMEs: POLLARD, KATHERINE S. (contact)

PROJECT_TERMS: Address;Affect;Alzheimer's Disease;Alzheimer's disease model;Amyloid beta-Protein;Apolipoprotein E;Apolipoproteins;Atlases;Attention;Autopsy;Behavioral;Behavioral Assay;Bioinformatics;Biological Assay;Biology;Brain;brain tissue;Cell Nucleus;cell type;Cells;Cellular Assay;Code;cohort;Communities;Complex;computerized tools;Coupled;Data;Data Analyses;Data Collection;Data Display;data exploration;data integration;data portal;Data Science Core;Data Set;deep learning;design;Disease;disease model;diverse data;Electrophysiology (science);epigenome;Etiology;Experimental Designs;experimental study;Gene Expression;Gene Expression Regulation;Generations;Genes;Genetic;Genetic Predisposition to Disease;genetic variant;genomic data;Genomics;Genotype;Goals;high dimensionality;Human;humanized mouse;Impaired cognition;improved;Inherited;innovation;Intuition;large scale data;Lead;Libraries;Link;Machine Learning;machine learning method;Measures;Modeling;Molecular;mouse model;multimodality;Mus;network dysfunction;network models;neural network;Neurons;neuropathology;novel;open source;Pathologic;Pathology;Pattern;Phenotype;phenotypic data;power analysis;predictive modeling;Procedures;Process;Program Research Project Grants;programs;Protocols documentation;Public Domains;Regulator Genes;Research;Research Design;Resources;response;Sampling;sequencing platform;single nucleus RNA-sequencing;Source Code;Standardization;Statistical Models;statistics;Synapses;System;Systems Development;tau Proteins;Techniques;Testing;Time;Tissue Donors;Tissues;tool;transcriptome;transcriptomics;user-friendly;Variant;Visualization;web portal;web site

PROJECT_TITLE: Core B: Integrative Data-Science Core


NIH_SPENDING_CATS: Cancer;Networking and Information Technology R&D (NITRD);Ovarian Cancer;Patient Safety;Rare Diseases;Women's Health Research

PHR: Project Narrative The deployment of appropriate analytic techniques and careful data management are an essential component for all Roswell Park Ovarian Cancer SPORE projects. The Biostatistics and Bioinformatics Core will ensure that the essential biostatistics and bioinformatics support and resources are readily available to all SPORE research projects.

PI_NAMEs: KARRISON, THEODORE GEORGE (contact)

PROJECT_TERMS: Acceleration;Address;anti-cancer research;Basic Science;Bioconductor;Bioinformatics;bioinformatics resource;Biometry;Cancer Center Support Grant;career;Clinical;clinical application;Clinical Sciences;clinical translation;Clinical Trials;Clinical Trials Data Monitoring Committees;Collaborations;Communities;Comprehension;Computer software;Data;Data Analyses;Data Collection;Data Commons;Data Coordinating Center;data management;data portal;data repository;data sharing;data sharing networks;Dedications;design;Development;Ensure;Faculty;Formulation;Fostering;Foundations;Funding;Genomics;Goals;Gynecologic Oncology Group;high standard;Immunooncology;Immunotherapy;improved;Individual;Infrastructure;International;Lead;Malignant neoplasm of ovary;Malignant Neoplasms;Manuscripts;member;Methodology;National Clinical Trials Network;novel;Oncology;open source;Outcome;Policies;prevent;Privacy;Procedures;Productivity;Program Research Project Grants;programs;Protocol Compliance;PubMed;Reporting;Reproducibility;Research;Research Personnel;Research Project Grants;research study;Resources;Services;Techniques;Text;translational oncology;Translational Research;Translations;United States National Institutes of Health;web portal

PROJECT_TITLE: Biostatistics and Bioinformatics Core


NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: Chicago

ORG_NAME: NORTHWESTERN UNIVERSITY

ORG_STATE: IL

PHR: Project Narrative ATP-binding cassette (ABC) transporters utilize many mechanisms to ensure efficient nutrient uptake while regulating toxins. Regulatory domains are not conserved in all ABC importers, indicating more variability in ABC importers beyond the current Type I/II classification scheme (Rice, Park et al., 2014). The proposed research will define the mechanism in which transporters can shut off transport based on environmental cues, which is a critical, but often overlooked, aspect to understanding basic nutrient uptake and survival mechanisms.

PI_NAMEs: PINKETT, HEATHER WENDY (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TERMS: Adenosine Triphosphate;anti-microbial drug;anti-microbial peptide;Antibiotics;ATP-Binding Cassette Transporters;Bacteria;Binding;Binding Proteins;Biochemical;Biochemistry;Biological Assay;Biological Models;Biophysics;Cell membrane;Cell secretion;Cell Survival;Cells;Classification Scheme;cofactor;Complex;Core Assembly;Cues;Cytolysis;Cytoplasm;Data;Development;dimer;Ensure;Environment;Epithelial Cells;experimental study;Family;Gatekeeping;Genes;Goals;Heme;Hydrolysis;Immune;Immune response;Infection;insight;Iron;Laboratories;Length;Mediating;Membrane;microbial;Molecular;Molecular Conformation;Nickel;novel;Nutrient;Organism;pathogen;pathogenic bacteria;peptide structure;Peptides;Play;Positioning Attribute;programs;Proteins;Reaction;recruit;Recycling;Regulation;Research;Research Personnel;Resistance development;Rice;Role;sensor;Site;Specificity;structural biology;Structure;Sulfur;System;Testing;Toxic effect;Toxin;uptake;Virulence;Work

PROJECT_TITLE: Regulation mechanisms of ABC transporters

STUDY_SECTION: MSFA

STUDY_SECTION_NAME: Macromolecular Structure and Function A Study Section[MSFA]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

PI_NAMEs: HUANG, YADONG  (contact)

PROJECT_TERMS: Abeta synthesis;Affect;Age;Age of Onset;age related;Alleles;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease risk;Amyloid beta-Protein;Apolipoprotein E;apolipoprotein E-4;Astrocytes;Behavioral;Brain region;Cell Culture Techniques;cell type;Cells;Clinical Research;Cognition;Collaborations;Dose;Enterobacteria phage P1 Cre recombinase;Etiology;Frontotemporal Dementia;Genes;Genetic;genetic risk factor;Hippocampus;Human;Individual;insight;Knock-in;Knowledge;LoxP-flanked allele;Microglia;Molecular;mouse model;Mus;mutant;Nature;network dysfunction;Network-based;neural network;neurofibrillary tangle formation;Neurofibrillary Tangles;Neurons;novel;Pathogenesis;Pathologic;Pathology;Pathway interactions;Population Study;prevent;Program Research Project Grants;Protein Isoforms;Role;single nucleus RNA-sequencing;tau Proteins;therapeutic target;therapy development;transcriptomics;Virulence Factors

PROJECT_TITLE: Project 1: Differential Roles of ApoE Isoforms in Neural Network Dysfunction of Alzheimer's Disease