NIH_SPENDING_CATS: Bioengineering;Biotechnology;Data Science;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: COLD SPRING HARBOR

ORG_NAME: COLD SPRING HARBOR LABORATORY

PHR: PROJECT NARRATIVE Deciphering the complex coordination of transcription factor binding to cis-regulatory elements along DNA is fundamental to understand transcriptional regulation. Deep learning has demonstrated great promise at modeling functional genomics data, but it remains difficult to understand how they come to their decisions. This project will develop new model interpretability methods to decipher the motifs and their syntax learned by genomic DNNs, providing a suite of timely computational tools for the biomedical community that will have direct applications to fundamental problems in basic biological science as well as to the understanding and treatment of human diseases.

PI_NAMEs: KOO, PETER K (contact)

PROGRAM_OFFICER_NAME: WANG, PEGGY

PROJECT_TERMS: Acceleration;Address;Affect;ATAC-seq;base;Benchmarking;Binding;bioinformatics tool;Biological;Biological Assay;Biological Sciences;biological systems;Biology;Black Box;cell type;Chromatin;Communities;Complex;Computer software;computerized tools;Computing Methodologies;Data;deep learning;deep neural network;Development;direct application;Disease;DNA;DNA Sequence;Ensure;explainable machine learning;functional genomics;Future;Genetic Transcription;genomic data;Genomics;geometric structure;Goals;human disease;improved;Individual;innovation;insight;Knowledge;Learning;Machine Learning;machine learning method;Maps;Methods;Modeling;new technology;Noise;Nucleotides;open source;Performance;performance tests;Population;Positioning Attribute;predictive modeling;Recurrence;Regulation;Regulatory Element;Resolution;Series;Signal Transduction;Single Nucleotide Polymorphism;Specific qualifier value;Structure;syntax;technology research and development;TensorFlow;Time;tool;Training;transcription factor;Transcriptional Regulation;Translating;Untranslated RNA;user-friendly

PROJECT_TITLE: Reliable post hoc interpretations of deep learning in genomics

STUDY_SECTION: GCAT

STUDY_SECTION_NAME: Genomics, Computational Biology and Technology Study Section[GCAT]


ADMINISTERING_IC: CA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Digestive Diseases;Immunotherapy;Orphan Drug;Pancreatic Cancer;Rare Diseases

ORG_CITY: ANN ARBOR

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PHARMACOLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE Pancreatic cancer is projected to become the second leading cause of cancer-related death in the United States by 2030, and is characterized by a dense, fibroinflammatory stroma and a hypoxic tumor microenvironment which can contribute to immunosuppression. The goal of this proposal is to determine how hypoxia regulates CD8+ T cell infiltration and function via macropahges and fibroblasts in pancreatic cancer. My studies will provide new insight on the hypoxic regulation of tumor-stroma crosstalk leading to immune suppression, and inform the optimal design of immunotherapies for pancreatic cancer.

PI_NAMEs: MELLO, ASHLEY  (contact)

PROGRAM_OFFICER_NAME: ADAMS, GREGORY

PROJECT_TERMS: Affect;Antitumor Response;Area;Beds;cancer cell;Cancer Etiology;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Physiology;Cells;Cessation of life;checkpoint therapy;Chemotactic Factors;Clinical;CXCL9 gene;cytokine;cytotoxic;cytotoxic CD8 T cells;Data;Data Set;design;Desmoplastic;Development;Disease;Exclusion;exhaustion;experience;Exposure to;Fibroblasts;Glioblastoma;Goals;Human;Hypoxia;Immune Evasion;Immunosuppression;Immunotherapeutic agent;Immunotherapy;In Vitro;Infiltration;Inflammatory;insight;LIF gene;Macrophage;Malignant neoplasm of pancreas;Malignant Neoplasms;Measures;Mediating;Mus;neoplastic cell;neutralizing antibody;normoxia;novel therapeutic intervention;Nutrient;Organoids;Oxygen;pancreatic cancer cells;Pancreatic Ductal Adenocarcinoma;pancreatic neoplasm;Patient-Focused Outcomes;Play;Population;prevent;Proliferating;Property;Reaction;recruit;Regulation;Repression;Resistance;response;Role;single-cell RNA sequencing;Stromal Cells;Survival Rate;T cell infiltration;T-Cell Activation;T-Lymphocyte;targeted treatment;Testing;Tissues;tumor;tumor hypoxia;tumor microenvironment;tumor progression;tumor-immune system interactions;tumorigenesis;United States;Vascularization

PROJECT_TITLE: Role of hypoxia in CD8+ T cell exclusion and suppression in pancreatic cancer


ADMINISTERING_IC: AG

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

PHR: Project Narrative Establishing how early and mid-life social relations are associated with ADRD risk in different racial/ethnic groups risk provides an innovative, cost effective opportunity to identify modifiable factors in midlife for ADRD risk. This project will capitalize on an existing longitudinal cohort study of detailed social relations over 28 years in a diverse lifespan sample and add cognitive and genetic measures, as well as extend racial/ethnic group comparisons to include Arab Americans in a new regionally representative adult sample in metro-Detroit. Characterizing how social relations vary as a function of race/ethnicity and clarifying unique links to ADRD risk will advance the field in terms of theory and intervention.

PI_NAMEs: ANTONUCCI, TONI CLAUDETTE (contact)

PROGRAM_OFFICER_NAME: KING, JONATHAN W

PROJECT_TERMS: Adult;Age;aged;Alzheimer's Disease Pathway;Alzheimer's disease related dementia;American;Apolipoprotein E;Arabs;Area;behavior measurement;Black Populations;Buffers;Characteristics;Cognition;Cognitive;cohort;comparison group;cost effective;critical period;culturally appropriate intervention;Data;Data Collection;dementia risk;design;Dimensions;Disparity;disparity reduction;Economics;Electronic Mail;ethnic disparity;ethnic minority population;Ethnic Origin;Ethnic Population;experience;Genes;Genetic;Genotype;Health;Incidence;Influentials;innovation;Intervention;late life;Learning;Life Cycle Stages;life span;Link;Longitudinal cohort study;Longitudinal Studies;Measures;member;metropolitan;middle age;Modeling;Modification;novel;Pattern;protective factors;Race;racial difference;racial disparity;racial minority population;racial population;recruit;Resources;Risk;Risk Factors;Sampling;social;social interventions;Socioeconomic Factors;Spouses;Stress;Structure;Testing;theories;trend

PROJECT_TITLE: Racial/Ethnic Disparities in ADRD Risk: The Impact of Social Relations

STUDY_SECTION: SSPA

STUDY_SECTION_NAME: Social Sciences and Population Studies A Study Section[SSPA]


ADMINISTERING_IC: GM

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: JACKSON

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF MISSISSIPPI MED CTR

ORG_STATE: MS

PHR: OVERALL NARRATIVE Cardiovascular, kidney and metabolic diseases are the leading causes of mortality and morbidity in the United States, especially in Mississippi which has the highest prevalence in the nation of these diseases. This is a critical area for research development in Mississippi in view of the emerging opportunities to develop a comprehensive, multidisciplinary research center at UMMC that focuses on these major causes of mortality and morbidity. This proposal represents a plan for continued development, via Phase 3 COBRE funding, of a unique, Cardiorenal and Metabolic Diseases Research Center (CMDRC) that is dedicated to improving lives through research, discovery, innovation, and translation to prevent and reduce death and disability from cardiorenal and metabolic diseases.

PI_NAMEs: HALL, JOHN E (contact)

PROGRAM_OFFICER_NAME: KOVBASNJUK, OLGA NIKOLAEVNA

PROJECT_TERMS: Acceleration;Area;Basic Science;Biomedical Research;Book Chapters;Books;Cardiorenal syndrome;Cardiovascular Diseases;cardiovascular risk factor;Cardiovascular system;Centers of Research Excellence;Cessation of life;Clinical;clinical center;Clinical Research;Collaborations;Complex;Core Facility;Coronary Arteriosclerosis;Dedications;Development;Diabetes Mellitus;disability;Discipline;Disease;Education;Ensure;Equipment;Extramural Activities;Faculty;Fostering;Funding;Grant;Healthcare Systems;High Prevalence;Hypertension;improved;Infrastructure;innovation;Institution;Interdisciplinary Study;International;Kidney Diseases;kidney dysfunction;Laboratory Research;Link;Mentors;Metabolic Diseases;minority investigator;Mississippi;Morbidity - disease rate;mortality;multidisciplinary;next generation;novel therapeutic intervention;Obesity;Paper;Phase;Pilot Projects;Population;Population Research;Postdoctoral Fellow;prevent;Productivity;programs;Publishing;recruit;Renal function;Research;research and development;Research Infrastructure;Research Personnel;Resources;Scientist;Services;Stroke;student training;success;Training;Training Programs;Translational Research;Translations;Underrepresented Minority;United States;United States National Institutes of Health;Work


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding

PHR: CORE A - ADMINSTRATIVE, EDUCATION AND MENTORING CORE NARRATIVE The Cardiorenal and Metabolic Diseases Research Center (CMDRC) has diverse functions and is comprised of multiple components, including a Pilot Projects Program, a Mentoring and Education Program, and two Research Resources Cores. Essential functions of the Administrative, Mentoring and Education Core A are to coordinate and facilitate activities of these components, and provide support for all Center related activities. Core A will further develop and implement mentoring and education programs for investigators and trainees of the Center, and interface with the NIGMS, the University of Mississippi Medical Center (UMMC) administration, the UMMC Grants and Contracts office, the departments represented in the CMDRC, other Centers at UMMC with shared research interests, and partner institutions.

PROJECT_TERMS: Award;Cardiorenal syndrome;Cardiovascular Diseases;career;career development;Centers of Research Excellence;Cessation of life;clinical center;Clinical Research;Collaborations;Communication;Computer software;Computer Systems;Computers;Contracts;Core Facility;Data;Dedications;Department chair;design;Development;disability;Disease;Education;Effectiveness;Environment;Equipment;Evaluation;Extramural Activities;Faculty;Faculty Recruitment;Fostering;Funding;Goals;Grant;Growth;improved;Infrastructure;infrastructure development;innovation;Institution;Interdisciplinary Study;interest;International;Kidney Diseases;Leadership;Medical center;meetings;member;Mentors;Metabolic Diseases;minority investigator;Mississippi;National Institute of General Medical Sciences;next generation;operation;Phase;Pilot Projects;Policies;Population Research;Postdoctoral Fellow;prevent;Productivity;Program Development;programs;recruit;Reporting;Research;Research Infrastructure;Research Personnel;Resource Sharing;Resources;scientific organization;Secure;Services;Students;symposium;Training;Translational Research;Translations;Underrepresented Minority;United States National Institutes of Health;Universities;web site


ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: Project Narrative Advanced metastatic castration-resistant prostate cancer (mCRPC) is a highly prevalent and lethal malignancy that is partially responsive to prostate-specific membrane antigen-targeted radiopharmaceutical therapy (PSMA-RPT). Proposed studies will leverage representative preclinical models of prostate cancer to perform integrated analyses of molecular and immune changes in tumor cells and the tumor microenvironment. These studies will guide the development of rational and effective combination therapies against mCRPC for future clinical translation.

PI_NAMEs: CZERNIN, JOHANNES  (contact);MONA, CHRISTINE E;RADU, CAIUS GABRIEL

PROGRAM_OFFICER_NAME: CAPALA, JACEK

PROJECT_TERMS: Agonist;androgen independent prostate cancer;Antigen Targeting;Attenuated;Cancer Patient;Cell Compartmentation;Cell Line;Cells;Clinical;clinical application;clinical translation;Combined Modality Therapy;Cyclic GMP;Cytometry;Data;Development;dimensional analysis;DNA;DNA Damage;dosimetry;Engineering;FOLH1 gene;Future;Genetic;Genetic Transcription;Histone Deacetylase Inhibitor;Human;Immune;Immunocompetent;immunogenicity;Immunologics;Impairment;improved;Innate Immune Response;Interferon Type I;Interferons;Knock-out;Link;Literature;Malignant Neoplasms;Mass Spectrum Analysis;Mediating;MEK inhibition;Modeling;Molecular;Molecular Analysis;mouse model;Mus;mutant;Mutate;Mutation;mutational status;neoplastic cell;novel;Pathway interactions;Patients;pharmacologic;phosphoproteomics;Play;Pre-Clinical Model;Production;prostate cancer model;Prostatic Neoplasms;Radiopharmaceuticals;rational design;Relapse;repaired;Resistance;response;Role;Signal Induction;Signal Transduction;single-cell RNA sequencing;Stimulator of Interferon Genes;synergism;targeted treatment;Testing;Time;TP53 gene;transcriptome sequencing;Treatment Efficacy;tumor;Tumor Immunity;tumor microenvironment;tumor progression;tumor-immune system interactions;Up-Regulation

PROJECT_TITLE: Multidimensional analyses to improve PSMA-RPT efficacy in mCRPC

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CTH-R(56)R]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: HOUSTON

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: Staphylococcus aureus infections are a major healthcare threat responsible for over 80,000 hospitalizations every year, and the majority of these infections originate from S. aureus carried in the nose. This project will address how mucus in the nasal passages and colonization by a potentially beneficial bacterium, Dolosigranulum pigrum, can prevent S. aureus colonization in the nose and therefore prevent serious infections.

PI_NAMEs: BOYD, ANDREA IVEY (contact)

PROGRAM_OFFICER_NAME: MOITRA, KAROBI

PROJECT_TERMS: Address;Adult;Affect;Agar;airway epithelium;Antibiotics;Antimicrobial Resistance;Bacteria;bacterial genetics;Behavior;Biological Models;Biology;Carbon;Cell Culture Techniques;cell immortalization;Cells;Collaborations;Colony-forming units;Complex;Corynebacterium;CRISPR/Cas technology;Data;Data Analyses;Distant;Environment;Enzyme-Linked Immunosorbent Assay;Epithelium;expectation;Experimental Designs;fitness;Fluorescent in Situ Hybridization;Genes;Genetic;Genetic Transcription;Goals;Growth;gut bacteria;Healthcare;healthcare burden;Hospitalization;Host Defense;host-microbe interactions;Hour;Human;Individual;Infection;Infection prevention;innovation;insight;Integration Host Factors;Knowledge;Learning;Libraries;Literature;member;Methods;Microbe;microbiota;microbiota composition;Microscopy;Modeling;MUC5AC gene;MUC5B gene;Mucin-2 Staining Method;Mucins;Mucous body substance;Mucous Membrane;mutant;Nasal Epithelium;nasal microbiota;Nose;Organism;Organoids;pathobiont;Pathogenesis;Pathogenicity;Phenotype;Physiological;Piedra;prevent;Prevention;Principal Investigator;Process;Production;protein expression;Proteins;Research;Risk Factors;Signal Transduction;Signaling Molecule;Site;skills;Source;Staphylococcus aureus;Staphylococcus aureus infection;success;System;Techniques;Temperature;Testing;Thick;Time;Training;Transcript;transcriptome;transcriptome sequencing;Vaccines;Virulence Factors

PROJECT_TITLE: Effect of Mucins and Dolosigranlulum pigrum on Staphylococcus aureus nasal colonization


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: COLLEGE PARK

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

ORG_STATE: MD

PHR: Public Health Relevance Despite significant progress in improving child survival, sub-Saharan Africa continues to have some of the worst outcomes for children’s physical growth and early child development. In this project, we develop a new measure of union formalization and refine an existing survey instrument on kinship support to understand how social correlates, specifically, kinship and marriage, impact children’s health and development in a low-income urban context in Kenya. The ultimate goal of the study is to identify models of family support that offer optimum protection for vulnerable mothers and young children.

PI_NAMEs: MADHAVAN, SANGEETHA  (contact)

PROGRAM_OFFICER_NAME: JEKIELEK, SUSAN

PROJECT_TERMS: Africa;Africa South of the Sahara;African;Age;aged;Biological;Breast Feeding;Child;Child Development;Child Health;Child Welfare;cognitive development;cognitive testing;Communities;Data;Data Collection;Development;Divorce;early childhood;Environmental Risk Factor;Equation;Etiology;Family;family support;Fathers;follow-up;Funding;Goals;Growth;Health;Health Services Accessibility;Household;improved;Infant;Infant Health;Infrastructure;innovation;instrument;Intervention;Kenya;Legal;Longitudinal Studies;Low income;Marriage;Masks;maternal wellbeing;Measures;Mediating;Mediation;men;Mental Health;Methodology;Methods;Modeling;Mothers;multidisciplinary;National Institute of Child Health and Human Development;Never Married;Nuptiality;nutrition;Outcome;Pathway Analysis;Pattern;Personal Satisfaction;Process;public health relevance;Research;residence;Risk;Role;Sampling;Scholarship;Shapes;Site;Slum;social;Social Change;Socioeconomic Status;success;Surveys;System;Testing;Time;tool;Trees;urban area;Urban Community;Urbanization;Variant

PROJECT_TITLE: Kinship, Nuptiality and Child Health Outcomes in a Low Income Urban Area


PHR: CORE B – BIOANALYTICAL, CARDIOMETABOLIC PHENOTYPING, IMAGING AND HISTOLOGY CORE PROJECT NARRATIVE The Bioanalytical, Cardiometabolic Phenotyping, Imaging and Histology Core B provides access to technologies and services that would otherwise not be available in Mississippi. The Bioanalytical Sub-Core provides centralized radioimmunoassay (RIA), ELISA, and chemistry analyses, the Cardiometabolic Phenotyping Sub- Core provides centrally located, state-of-the-art, highly specialized in vivo phenotypical testing to characterize physiological and behavioral parameters in genetic and pharmacological research models of obesity, cardiovascular and metabolic disease, and the Imaging and Histology Sub-Cores provide access to state-of– the-art imaging equipment as well as histology, immunohistochemistry, and other key services. This Core is staffed by professional personnel who are not only capable of performing a variety of essential research services, but are also able to provide training and assist in the development of new research methods to meet the changing needs of COBRE investigators.

PI_NAMEs: ALEXANDER, BARBARA T (contact)

PROJECT_TERMS: Basic Science;Behavioral;Biochemical;Biological Assay;Blood-Borne Pathogens;Businesses;Capital;cardiometabolism;Cardiorenal syndrome;Cardiovascular Diseases;Centers of Research Excellence;Charge;Chemistry;Clinical;Core Facility;cost;Coupled;Data;Development;Discipline;Disease;doctoral student;Ensure;Enzyme-Linked Immunosorbent Assay;Equipment;experience;Extramural Activities;Faculty;Fee-for-Service Plans;Fostering;Funding;Funding Agency;Generations;Genetic;Goals;Grant;Hazardous Chemicals;High Prevalence;Histologic;Histology;Historically Black Colleges and Universities;Human Resources;Image;Immunohistochemistry;improved;In Vitro;in vivo;in vivo imaging;Individual;Industry;Infrastructure;Institution;instrumentation;Kidney Diseases;Laboratories;Maintenance;Measurement;member;Mentors;Metabolic;Metabolic Diseases;Mississippi;Modeling;Morbidity - disease rate;mortality;multidisciplinary;new technology;novel strategies;Obesity;pharmacologic;Phase;Phenotype;Physiological;Policies;Population;Postdoctoral Fellow;pre-doctoral;Procedures;Publications;Radiation;Radioimmunoassay;Recovery;Regulation;Research;Research Infrastructure;Research Methodology;Research Personnel;Resources;Safety;Scientist;service utilization;Services;Standardization;Students;success;Supervision;System;Technical Expertise;Technology;Testing;Training;United States;United States National Institutes of Health;Universities;Update


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Cost Effectiveness Research;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Homelessness;Prevention;Primary Health Care;Social Determinants of Health

ORG_CITY: SAN FRANCISCO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative Current HIV care models do not meet the needs of many people living with HIV (PLH), especially those who experience homelessness, mental illness, and substance use. This study will support the implementation and evaluation of an integrated comprehensive drop-in and mobile care approach for PLH who have challenges engaging in usual care. This care approach will be tested in four diverse care sites in San Francisco and Alameda counties (an academic safety-net HIV clinic, a syringe access site, and two federally qualified health centers).

PI_NAMEs: CHRISTOPOULOS, KATERINA A (contact);HICKEY, MATTHEW

PROGRAM_OFFICER_NAME: MCKAIG, ROSEMARY G

PROJECT_TERMS: addiction;Address;Adoption;African American population;antiretroviral therapy;Appointment;Appointments and Schedules;Area;barrier to care;Black race;care delivery;care systems;Caring;Case Management;Chronic;Clinic;Clinical;clinical effect;Clinical effectiveness;cohort;Communities;community burden;community clinic;Community Healthcare;Complex;Consolidated Framework for Implementation Research;Control Groups;Cost Effectiveness Analysis;Costs and Cost Analysis;County;COVID-19 testing;COVID-19 vaccine;Criminal Justice;Data;design;Discipline of Nursing;Disparity;Drops;Effectiveness;effectiveness evaluation;effectiveness/implementation study;Eligibility Determination;Epidemic;Evaluation;experience;Federally Qualified Health Center;flexibility;follow-up;Food;Goals;health data;health equity;Heterogeneity;Hispanic Populations;HIV;Homeless persons;Homelessness;housing instability;Hybrids;implementation facilitators;implementation framework;implementation intervention;implementation outcomes;implementation research;implementation science;implementation strategy;implementation/effectiveness;improved;Individual;innovation;integrated care;interdisciplinary treatment approach;Intervention;Knowledge;Latino;Literature;Maintenance;Maps;Medical;Medicine;Mental disorders;Methods;Modeling;multidisciplinary;Needle-Exchange Programs;novel strategies;Outcome;outreach;Patients;Persons;Pharmacy facility;Pilot Projects;Population;Population Sciences;Primary Care;primary care visit;primary outcome;Process;programs;Psychiatry;psychosocial;Public Health;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recording of previous events;Research;Safety;safety net;San Francisco;Schedule;service delivery;severe mental illness;Site;Social Work;Structural Racism;substance use;Substance Use Disorder;Syringes;System;Testing;treatment as usual;Treatment outcome;United States;Urban Population;Viral;Viral Load result;Vulnerable Populations;Work

PROJECT_TITLE: Staged Low-Barrier and Mobile Care to Improve Retention and Viral Suppression in Hard-To-Reach Vulnerable People Living With HIV


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Dental, Oral, and Craniofacial Disease;Genetics;Human Genome;Infectious Diseases

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: Narrative Epstein-Barr virus (EBV) causes infectious mononucleosis, oral hairy leukoplakia, lymphoma, nasopharyngeal and gastric carcinoma. These studies will increase understanding of how EBV genome structure controls the viral lytic switch, which may lead to novel therapeutic approaches.

PI_NAMEs: GEWURZ, BENJAMIN ELISON (contact)

PROGRAM_OFFICER_NAME: PARK, EUN-CHUNG

PROJECT_TERMS: 3-Dimensional;Adult;antagonist;Antigens;Architecture;Auxins;B-Lymphocytes;Binding;Binding Sites;BZLF1 gene;Cell Compartmentation;Cell Nucleus;Cells;ChIP-seq;Chromatin Conformation Capture and Sequencing;Chromatin Loop;Clustered Regularly Interspaced Short Palindromic Repeats;cohesin;Complex;CRISPR screen;crosslink;Cues;DNA Polymerase II;ds-DNA;EBV-associated disease;Engineering;Epigenetic Process;Epithelium;Epstein-Barr Virus latency;Gene Expression;Gene Expression Regulation;Genetic Transcription;Genome;genome-wide;Hairy Leukoplakia;Human Genome;Human Herpesvirus 4;Immediate-Early Genes;Immune Evasion;Immune response;Immunoglobulins;in vivo;Infection;Infectious Mononucleosis;insight;Integration Host Factors;Knowledge;Learning;Location;Lymphoma;Lytic;Lytic Phase;lytic replication;Lytic Virus;Malignant neoplasm of nasopharynx;Malignant Neoplasms;malignant stomach neoplasm;Maps;Mediator;Memory B-Lymphocyte;Methylation;Molecular Conformation;Nasopharynx Carcinoma;novel therapeutic intervention;Oral cavity;Pathway interactions;Phosphorylation;Physiological;plasma cell differentiation;PRDM1 gene;programs;promoter;Proto-Oncogene Proteins c-myc;Regulation;release factor;Repression;Resolution;response;RNA;Role;Saliva;Series;single molecule;Stomach Carcinoma;Structure;System;Therapeutic;Tonsil;transcription factor;Transcription Factor AP-1;Transcriptional Regulation;transmission process;tumorigenesis;Viral;Viral Genome;viral genomics;Viral Proteins;Virion;Withdrawal;Xenograft procedure

PROJECT_TITLE: Regulation of the Epstein-Barr Virus Lytic Switch


ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: JUNEAU

ORG_NAME: ALASKA STATE DEPT/ENVIRONMTL CONSERVATN

ORG_STATE: AK

PHR: Grant Number TBD  Alaska Department of Environmental Conservation, PATH B The FDA's Cooperative Agreement Program for States and Territories to Implement a  National Produce Safety Program PAR-21-174  Project Period: 2021-2026 Project Narrative The implementation of the Produce Safety Rule (PSR) is one important element in creating the proactive and preventive food safety system envisioned by the Food Safety Modernization Act (FSMA). This project is designed to assist the FDA in advancing efforts for a national integrated food safety system (IFSS) by enhancing produce safety and achieving high rates of compliance with the PSR by way of a state regulatory program in Alaska focused on quality and national consistency, as well as education and technical assistance for growers. At the conclusion of this cooperative agreement we anticipate having a developed, sustainable Alaska Produce Safety Program; a farming community educated on the requirements of the PSR and good agricultural practices; a fully-verified inventory of Alaskan produce farms; a high- quality inspectional program consistent with national practices; developed protocols for compliance and enforcement activities; and protocols and partnerships in place to respond to emergency situations such as outbreaks and recalls. Additional information is included under the attachments for Specific Aims and Project Plan.

PI_NAMEs: BRANVOLD-FABER, HEATHER  (contact)

PROGRAM_OFFICER_NAME: HOEHNA, SHANNON

PROJECT_TITLE: Path B State of Alaska, Department of Environmental Conservation (DEC), Enhance Produce Safety through a Quality Regulatory Program, and by Providing Education and Technical Assistance


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Drug Abuse (NIDA only);Natural Products;Neurosciences;Nutrition;Substance Misuse

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: Project Narrative The proposed research is relevant to public health because it focuses on identifying mechanisms of toxicokinetic interactions when areca (betel) nut abusers co-ingest other substances such as alcohol or menthol. This project will not only bring us closer to implementing strategies to mitigate these adverse interactions, but also enrich our understanding of areca nut addiction. Thus, the proposed research is relevant to the part of The National Institute of Drug Abuse (NIDA) mission that pertains to advancing scientific discoveries about the consequences of drug abuse.

PI_NAMEs: MYERS, ALAN L (contact)

PROGRAM_OFFICER_NAME: HILLERY, PAUL

PROJECT_TERMS: 3-Dimensional;addiction;Alcohol consumption;Alcohols;Areca;Arecoline;Binding Proteins;Biological;Biological Markers;Biomimetics;Blood;Brain;brain tissue;Caffeine;carboxylesterase;Carboxylesterase 1;Cell Survival;Cellular biology;Clinical Pharmacology;commercialization;Communities;Consumption;Data;Decision Making;disorder risk;Drug abuse;Drug Addiction;Drug Interactions;Drug Kinetics;drug metabolism;Enzymes;esterase;Esterification;Esters;Ethanol;Euphoria;Feeling;Female;Foundations;functional group;Future;Glutathione;Goals;Habits;Health;Hepatic;Human;Human body;Hydrolase;Hydrolysis;improved;in vivo;Individual;Ingestion;insight;Knockout Mice;Knowledge;Liver;Liver diseases;male;Malignant Neoplasms;Marketing;Mastication;Mediating;Menthol;Metabolic;Metabolism;Migrant;Mission;Modeling;Motor Activity;mouse model;Mus;National Institute of Drug Abuse;Neurobiology;Neurologic;Nicotine;Nicotinic Receptors;Nitrosamines;Nuts;Observational Study;Organoids;overexpression;Pathway interactions;Patients;Persons;Pharmaceutical Preparations;Pharmacodynamics;pharmacokinetics and pharmacodynamics;Pharmacology;Poison;Probability;Process;Property;Proxy;Public Health;Refugees;Research;Risk;Scientific Advances and Accomplishments;Self Administration;sex as a biological variable;Shunt Device;Site;substance abuser;Sulfhydryl Compounds;System;Testing;Tissues;Toxic effect;Toxicokinetics;Toxicology;Toxin;Xenobiotics

PROJECT_TITLE: Mechanisms of alcohol and menthol dependent pharmaco-neurological interactions with arecoline, an addictive and toxic areca (betel) nut xenobiotic

STUDY_SECTION: XNDA

STUDY_SECTION_NAME: Xenobiotic and Nutrient Disposition and Action Study Section[XNDA]


ORG_CITY: HELENA

ORG_NAME: MONTANA STATE DEPARTMENT OF AGRICULTURE

ORG_STATE: MT

PHR: The objective of the Montana Produce Safety Program project is to align itself with the Produce Safety Rule and implement the standards of the rule, while also providing outreach and technical assistance to growers. Such alignment will advance the overarching goal of decreasing the number of foodborne illnesses and outbreaks associated with fresh produce.

PI_NAMEs: SARCHET, ANDREA  (contact)

PROJECT_TITLE: Path C Montana Department of Agriculture Produce Safety Education, Outreach, Compliance, and Enforcement of the FSMA Produce Safety Rule - PATH C


NIH_SPENDING_CATS: Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Genetics;Human Genome;Obesity

PHR: CORE C – OMICS, BIOINFORMATICS AND FLOW CYTOMETRY CORE PROJECT NARRATIVE Obesity, cardiorenal and metabolic diseases are significant health issues in the United States, especially in Mississippi. The objective of Core C - Omics, Bioinformatics and Flow Cytometry of the Cardiorenal and Metabolic Diseases Research Center (CMDRC) is to provide to researchers access to state-of-the-art cell sorting/flow cytometry and omics technologies to generate unique cellular and molecular insights into these diseases.

PI_NAMEs: GARRETT, MICHAEL R (contact)

PROJECT_TERMS: African American population;Apoptosis;Bioinformatics;Biological;Biological Assay;Biological Process;Cardiorenal syndrome;Cell Cycle;Cell Nucleus;Cell Proliferation;Cell Separation;cell type;Cells;Centers of Research Excellence;Clinical;Complement;complex data;Consultations;Country;Data Set;Disease;Enhancement Technology;Ensure;epigenome;Equipment;Faculty;Faculty Workshop;Flow Cytometry;Funding;Gene Expression;Generations;Genetic;genome sequencing;genomic data;Genomics;glucose uptake;Goals;Health;High Prevalence;Historically Black Colleges and Universities;Immune;improved;Infrastructure;insight;Institution;Instruction;instrument;instrumentation;Maintenance;Mass Spectrum Analysis;meetings;Metabolic Diseases;Methodology;Mississippi;Molecular;Molecular Analysis;Molecular Biology;Morbidity - disease rate;mortality;multidisciplinary;multiple omics;Names;next generation sequencing;Nucleic Acids;Obesity;Phase;Phenotype;Pilot Projects;Population;programs;Proteomics;Quality Control;release of sequestered calcium ion into cytoplasm;Research;Research Personnel;Research Project Grants;Resources;Scientific Advances and Accomplishments;Scientist;service delivery;Services;single-cell RNA sequencing;Small RNA;Sorting;Students;Supervision;Systems Biology;Technical Expertise;Techniques;Technology;Training and Education;training opportunity;transcriptome;transcriptome sequencing;transcriptomics;undergraduate student;United States;whole genome;Work;XCL1 gene

PROJECT_TITLE: Omics, Bioinformatics and Flow Cytometry Core


ORG_CITY: ALBANY

ORG_NAME: NY STATE DEPT OF AGRICULTURE/ MARKETS

ORG_STATE: NY

PHR: PROJECT NARRATIVE The New York State Department of Agriculture and Markets project entitled: Continuing Development of a New York State Department of Agriculture and Markets Produce Safety Program Under Path C that will Enhance On-Farm Food Safety is intended to support and build upon the current Produce Safety Program in New York State. The project will promote best practices for the growing, harvesting, packing and holding of produce and achieve high rates of compliance with the FSMA Produce Safety Rule. The Department will utilize federal funding to develop project objectives as identified in FOA PAR-21-174. Realizing these objectives will enhance the current produce safety regulatory program in New York State and support further integration into a national Integrated Food Safety System. It is anticipated that through education and training along with enforcement and compliance of the Produce Safety Rule, there will be a reduction in foodborne illness associated with fresh produce grown, harvested, packed or held on New York State farms.

PI_NAMEs: AKHTAR, SAEED  (contact)

PROGRAM_OFFICER_NAME: FREDRICK, JEANETTE

PROJECT_TITLE: Path C CONTINUING DEVELOPMENT OF A NEW YORK STATE DEPARTMENT OF AGRICULTURE AND MARKETS PRODUCE SAFETY PROGRAM UNDER PATH C THAT WILL ENHANCE ON-FARM FOOD SAFETY


ADMINISTERING_IC: DK

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Inflammatory Bowel Disease;Machine Learning and Artificial Intelligence;Precision Medicine

PHR: Modified Public Health Relevance Section  Acute severe ulcerative colitis is a potentially life-threatening presentation of ulcerative colitis, which can lead to rapid clinical deterioration, emergent colectomy, and significant morbidity. Although multiple treatment options exist for acute severe ulcerative colitis, we have no evidence-based personalized treatment pathways that can be applied to improve colectomy-free survival. The proposed research will inform the development and optimization of patient-tailored adaptive treatment strategies to guide the type, intensity, and timing of pharmacologic therapy using tailoring variables to improve the rate of colectomy-free survival for patients with acute severe ulcerative colitis

PI_NAMEs: BERINSTEIN, JEFFREY  (contact)

PROGRAM_OFFICER_NAME: OSGANIAN, VOULA

PROJECT_TERMS: 18 year old;acceptability and feasibility;Accounting;Achievement;Acute;Address;Admission activity;Adrenal Cortex Hormones;analytical method;Applications Grants;Applied Research;Area;Award;Behavioral;brief intervention;C-reactive protein;Calcineurin inhibitor;career;Caring;Cessation of life;Characteristics;Clinical;Clinical Trials Design;cohort;Colectomy;cost;Crohn's disease;Cyclosporine;Data;Data Analyses;Data Analytics;Death Rate;Deterioration;Development;Discrimination;Disease;Early identification;effective therapy;efficacy evaluation;Ensure;evidence base;Feces;Frequencies;Future;General Hospitals;Goals;Growth;Health;Heterogeneity;Hospitalization;improved;Individual;individual patient;individual response;Inflammatory Bowel Diseases;infliximab;inhibitor;Institution;Intervention;Intravenous;Janus kinase;kinase inhibitor;Knowledge;Laboratories;Life;Link;Machine Learning;machine learning method;machine learning model;Malignant - descriptor;Massachusetts;Mentorship;Methods;Michigan;Modeling;Morbidity - disease rate;multidimensional data;novel strategies;Participant;Pathway interactions;Patient Admission;Patient Selection;Patients;personalized care;personalized medicine;personalized strategies;pharmacologic;Pharmacological Treatment;Physicians;Positioning Attribute;Prediction of Response to Therapy;predictive modeling;Preparation;Probability;prognostic;prospective;public health relevance;Randomized;Refractory;Research;Research Personnel;Research Proposals;Risk;Scientist;Sequential Multiple Assignment Randomized Trial;Sequential Treatment;Specific qualifier value;Steroids;symposium;Symptoms;Testing;Time;TNF gene;Training;Treatment Efficacy;Treatment Failure;treatment response;treatment strategy;trial design;Ulcerative Colitis;Universities;Work

PROJECT_TITLE: Development of Patient-Tailored Adaptive Treatment Strategies for Acute Severe Ulcerative Colitis

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: PROVIDENCE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: Cellular entry of SARS-CoV-2 is the primary target for vaccine and therapeutics development. This proposal seeks to determine by which LRRC15 inhibits entry of SARS-CoV-2 in trans.

PI_NAMEs: LEE, SANGHYUN  (contact)

PROGRAM_OFFICER_NAME: PLIMACK, MARY KATHERINE BRADFORD

PROJECT_TERMS: 2019-nCoV;ACE2;Affinity;Binding;Binding Sites;Biological Assay;C-Type Lectins;Cell membrane;cell type;Cells;COVID-19;COVID-19 patient;COVID-19 susceptibility;COVID-19 vaccine;CRISPR-mediated transcriptional activation;cytokine;Cytoplasm;Data;Data Set;DAXX gene;domain mapping;effectiveness evaluation;Epithelial Cells;Event;Fibroblasts;Genes;global health;Heparitin Sulfate;Human;insight;Interferons;Leucine-Rich Repeat;Libraries;Lung;Marketing;Mediating;member;Membrane Proteins;Modeling;Molecular;Molecular Conformation;Mutagenesis;Names;Neuropilin-1;novel;Pathologic;Pattern Recognition;Physiological;Proteins;receptor;receptor binding;Recombinant Proteins;Recombinants;Reporting;Role;SARS-CoV-2 entry inhibitor;SARS-CoV-2 genome;SARS-CoV-2 infection;SARS-CoV-2 spike protein;SARS-CoV-2 variant;screening;Signal Transduction;single-cell RNA sequencing;Stains;Stromal Cells;Surface;System;Therapeutic antibodies;therapeutic development;tumor;vaccine development;Variant;Viral;viral entry inhibitor;Virus;Work

PROJECT_TITLE: Entry inhibition of SARS-CoV-2 by human LRRC15

STUDY_SECTION: VIRA

STUDY_SECTION_NAME: Virology - A Study Section[VIRA]


PHR: PILOT PROJECTS PROGRAM NARRATIVE Cardiovascular and metabolic diseases are significant problems affecting the health of Mississippians. The Pilot Project Program (PPP) seeks to develop the next generation of researchers investigating cardiovascular and metabolic diseases by providing them funding and mentoring. Through this program, we will increase the number of researchers in cardiovascular and metabolic diseases that will ultimately have a positive impact on the overall health of Mississippians.

PI_NAMEs: STEC, DAVID E (contact)

PROJECT_TERMS: Affect;American Heart Association;Appointment;Area;base;Basic Science;Book Chapters;Cardiorenal syndrome;Cardiovascular Diseases;career;Categories;Centers of Research Excellence;Clinical Research;Clinical Sciences;Communities;Conflict of Interest;Data;Development;Discipline;Education;Eligibility Determination;Equity;ethnic diversity;Evaluation;experience;Exposure to;Extramural Activities;Faculty;Financial Support;Funding;gender diversity;Goals;Grant;Grant Review;Health;improved;Individual;innovation;International;Journals;Medical center;meetings;member;Mentors;Metabolic Diseases;mid-career faculty;Mississippi;multidisciplinary;next generation;novel;Paper;Phase;Pilot Projects;Population Research;Program Research Project Grants;programs;Publishing;Research;Research Infrastructure;Research Personnel;Research Project Grants;Research Proposals;Resources;Review Committee;satisfaction;Scientist;Series;Services;Study Section;success;Testing;translational potential;United States;United States National Institutes of Health;Universities

PROJECT_TITLE: Pilot Projects Program


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Neurosciences;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: ATLANTA

ORG_DEPT: GENETICS

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Relevance The opioid crisis has been declared a national Public Health Emergency under federal law, and new treatments to combat opioid abuse are essential. The goal of this research is to identify molecules and pathways in the brain that have the potential to reduce opioid use and may be targeted for novel addiction therapies.

PI_NAMEs: WEINSHENKER, DAVID  (contact)

PROGRAM_OFFICER_NAME: NAIR, SUNILA GOPI

PROJECT_TERMS: abuse liability;Acute;addiction;Adrenergic Receptor;Agonist;Anatomy;Attenuated;autocrine;Behavior;Behavioral;Behavioral Symptoms;Brain;Cell Nucleus;Cells;Chronic;combat;conditioned place preference;Data;Disinhibition;dopaminergic neuron;Dose;Electrophysiology (science);Frequencies;Galanin;galanin receptor;gamma-Aminobutyric Acid;Goals;Human;Hyperactivity;In Situ Hybridization;in vivo;Knock-out;Knockout Mice;Laws;Literature;Location;locus ceruleus structure;Maps;Measurement;Mediating;Messenger RNA;Molecular;Morphine;Mus;Neuroanatomy;neurochemistry;Neuronal Plasticity;Neurons;Neuropeptides;Neurotransmitters;noradrenergic;Norepinephrine;novel;novel therapeutics;Opiate Addiction;Opioid;opioid abuse;opioid epidemic;opioid exposure;opioid therapy;opioid use;opioid withdrawal;optogenetics;Overdose;overexpression;Pathway interactions;Persons;Pharmacology;Phase;Phenotype;prevent;Process;Property;Psychological reinforcement;public health emergency;receptor;Research;response;Rewards;Rodent;Self Administration;Slice;small molecule;Source;Symptoms;System;Testing;Transgenic Mice;Transgenic Organisms;transmission process;Ventral Tegmental Area;Wild Type Mouse;Withdrawal;Withdrawal Symptom

PROJECT_TITLE: Contribution of locus coeruleus-derived galanin to opioid reward and reinforcement

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


NIH_SPENDING_CATS: Complementary and Integrative Health;Digestive Diseases;Microbiome;Nutrition;Prevention

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF HOUSTON

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because understanding the mechanisms for how dietary essential metals affect gut microbiota composition and function will provide the knowledge base needed to prescribe efficacious metal- and probiotic-based dietary interventions and to devise therapeutic strategies for treating gastrointestinal diseases and infection. Thus, the proposed research is relevant to the part of NIGMS's mission that pertains to developing fundamental knowledge that will lay the foundation for disease treatment and prevention.

PI_NAMEs: ZASTROW, MELISSA LYNN (contact)

PROGRAM_OFFICER_NAME: SIMONOVIC, MILJAN

PROJECT_TERMS: Affect;bacterial community;Cell Communication;Cells;Collaborations;combat;Communication;Dependence;Detection;Diet;dietary;Dietary Intervention;Disease;Fluorescence Microscopy;Foundations;Gastrointestinal Diseases;gastrointestinal infection;Genes;genetic approach;Goals;Growth;gut bacteria;gut microbiota;Homeostasis;Human;In Vitro;Infection;innovation;insight;Ions;Iron;Knowledge;knowledge base;Lactobacillus;Learning;Measures;Metals;Microbiology;microbiome;microbiota composition;Mission;Modeling;Molecular;National Institute of General Medical Sciences;new therapeutic target;Nutrient;Organism;Oxygen;Physiological;Physiology;Predisposition;Prevention;Probiotics;programs;Proteins;Public Health;quorum sensing;Research;Role;sensor;shift work;Signaling Molecule;Small Intestines;Therapeutic;Time;uptake;Work;Zinc

PROJECT_TITLE: Elucidating Molecular-Level Roles of Essential Metals in Gut Bacteria with New Fluorescent Protein-Based Metal Ion Sensors

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-N(55)R]


NIH_SPENDING_CATS: Genetics

ORG_CITY: WORCESTER

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: Project Narrative The scientific program of the principal investigator includes an investigation of the genes and mechanisms that control apoptosis and that initiate regenerative responses after massive stress- or injury induced apoptosis in multi-cellular organisms. Understanding the mechanisms of these processes may lead to new therapeutic interventions for cancer and regeneration.

PI_NAMEs: BERGMANN, ANDREAS  (contact)

PROGRAM_OFFICER_NAME: MASKERI, BAISHALI

PROJECT_TERMS: Adopted;Anti-Inflammatory Agents;Apoptosis;Apoptotic;Autoimmunity;behavior influence;Biological;Cancer Intervention;Caspase;Cell Communication;Cell Death;Cell Survival;Cells;chemotherapy;Compensation;Defect;Development;Disease;Doctor of Philosophy;Drosophila genus;Drosophila melanogaster;Environment;Generations;Genes;Genetic;Genetic Models;Genetic Screening;Growth;Hemocytes;Homeostasis;Human;improved;Induction of Apoptosis;injury stressor;Investigation;Macrophage;Malignant Neoplasms;Massachusetts;medical schools;Methods;model organism;Mus;Myocardial Infarction;Natural regeneration;neoplastic cell;Nerve Degeneration;novel therapeutic intervention;Organism;Pathogenesis;Pathologic;Phenotype;Principal Investigator;Process;programs;Proliferating;Radiation therapy;Reactive Oxygen Species;regenerative;Regenerative response;Regulation;Relapse;Research;Resistance;Signal Transduction;Stroke;Tissues;tumor;Universities;Xenopus

PROJECT_TITLE: Mechanisms and consequences of programmed cell death (apoptosis) and compensatory proliferation in Drosophila

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-T(55)R]


NIH_SPENDING_CATS: Genetics;HIV/AIDS;Infectious Diseases

ORG_CITY: SAN ANTONIO

ORG_NAME: TEXAS BIOMEDICAL RESEARCH INSTITUTE

PHR: Narrative This proposal aims to identify host lncRNAs that influence viral replication, disease outcomes, and molecular mechanisms of their action. The outcome from the study outlined in this proposal is identifying lncRNAs that regulate HIV propagation and contribute to the spontaneous control of HIV infection. The results will have a significant positive impact immediately as they will provide a better understanding of lncRNAs in HIV infection and disease outcomes, discover novel host factors that will be further evaluated for therapeutic potential.

PI_NAMEs: KULKARNI, SMITA  (contact)

PROGRAM_OFFICER_NAME: MCDONALD, DAVID JOSEPH

PROJECT_TERMS: Anti-sense RNA;Biochemical;Biology;candidate validation;CCR5 gene;CD4 Positive T Lymphocytes;Cell Count;Cell Cycle;Cell Line;Cell Physiology;cell transformation;Cells;Chronic;Clustered Regularly Interspaced Short Palindromic Repeats;Code;Collaborations;comparative;Complex;Data;Defense Mechanisms;Development;differential expression;Disease;Disease Outcome;Disease Progression;experience;Gene Expression;Gene Expression Regulation;gene network;Genes;Genetic Transcription;genome-wide;Global Change;Goals;Highly Active Antiretroviral Therapy;HIV;HIV Infections;HIV-1;Host resistance;Human;Immune;Infection;innovation;insight;Integration Host Factors;Intervention;Knowledge;Laboratories;Life Cycle Stages;Macrophage;Malignant Neoplasms;Mass Spectrum Analysis;Mediating;Methods;Modeling;Molecular;Natural Resistance;novel;novel strategies;novel therapeutic intervention;Outcome;Outcome Study;pathogen;patient prognosis;Patients;Positioning Attribute;protein function;Proteins;Proteomics;Regulation;Research;response;RNA;RNA Interference;RNA-Binding Proteins;Role;screening;Small Interfering RNA;Small RNA;Specificity;Techniques;Therapeutic;transcriptome;transcriptomics;transmission process;Untranslated RNA;Viral Genes;Virus;Virus Diseases;Virus Replication

PROJECT_TITLE: Role of cellular long non-coding RNAs in HIV replication and disease outcome

STUDY_SECTION: HVCD

STUDY_SECTION_NAME: HIV Molecular Virology, Cell Biology, and Drug Development Study Section[HVCD]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: COLUMBUS

ORG_NAME: RESEARCH INST NATIONWIDE CHILDREN'S HOSP

ORG_STATE: OH

PHR: PROJECT NARRATIVE This proposal is relevant to public health because there is currently no available treatment for children with long- segment airway defects. Tissue engineering has the potential to replace diseased tissue with healthy, living tissue capable of repair and growth. A composite tracheal graft that possesses the mechanical properties needed to maintain graft patency and the biocompatibility to support regeneration will provide a viable solution for this complex population.

PI_NAMEs: CHIANG, TENDY  (contact)

PROGRAM_OFFICER_NAME: LIN, SARA

PROJECT_TERMS: 3-Dimensional;Acceleration;Address;Adolescent;Air Movements;airway epithelium;airway obstruction;Animal Model;Animals;Attenuated;Autologous;Autologous Transplantation;Biochemical;Biocompatible Materials;Biological;biomaterial compatibility;Biomechanics;Biophysics;Biopsy;Bronchi;Bronchoscopy;Cartilage;cartilaginous;Cells;Child;Childhood;Chondrocytes;Chondrogenesis;Clinical;Clinical Management;clinical translation;Complex;conditional knockout;Congenital Abnormality;Cues;Data;Defect;Detection;Development;Diameter;Dimensions;Disease;efficacy testing;Epithelial Cells;Epithelium;epithelium regeneration;Expression Profiling;extracellular;Extracellular Matrix;Generations;Growth;Host Defense;Image;Immunofluorescence Immunologic;Implant;implantation;improved;Infection;Inflammation;Injury;innovation;Intervention;lamb model;Legal patent;Liquid substance;Maintenance;Malignant Neoplasms;Maps;Mass Spectrum Analysis;mechanical properties;Mechanics;Mediating;migration;Modeling;Modification;mouse model;Mucociliary Clearance;Mus;nanofiber;Natural regeneration;Operative Surgical Procedures;Organ;Outcome;Patients;Performance;Population;preservation;Production;progenitor;Proliferating;protein expression;Public Health;Radial;radiological imaging;repaired;replacement tissue;respiratory surgery;restoration;Role;shear stress;sheep model;Source;Splint Device;stem;Stents;stress reduction;Surface;Techniques;Testing;Time;Tissue Engineering;Tissue Preservation;Tissues;Trachea;Tracheal Diseases;translational barrier;Trauma;Work

PROJECT_TITLE: Tissue-engineered trachea composites for long-segment airway replacement

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Data Science;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE A fundamental question in biology is to understand how genetic variation affects genome function to influence phenotypes. Our in-depth characterization of functional impact of genomic variation on human developmental gene regulatory networks in ancestrally diverse populations will provide critical insights into human development and diseases and have the potential to greatly help translating disease risk alleles to therapeutic targets.

PI_NAMEs: SONG, HONGJUN ;WU, HAO  (contact)

PROGRAM_OFFICER_NAME: GILCHRIST, DANIEL A

PROJECT_TERMS: 3-Dimensional;Adherent Culture;Affect;African;African American;ATAC-seq;Automobile Driving;Bar Codes;Basic Science;Benchmarking;biological systems;Biology;Brain;Cardiac;causal variant;Cell Communication;Cell Differentiation process;Cell Line;Cell Lineage;cell type;Cells;Cellular Assay;Chromatin;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;combinatorial;Computational algorithm;computer framework;Computer Models;Computer software;computerized tools;Computing Methodologies;Data;data integration;Data Set;data sharing;Databases;deep learning;Development;Developmental Gene;disorder risk;DNA;DNA Methylation;Elements;Epigenetic Process;epigenome editing;epigenomics;European;Gender;Gene Expression;Gene Expression Regulation;gene regulatory network;Genes;Genetic;genetic variant;Genetic Variation;Genome;genome editing;Genomic Segment;genomic tools;genomic variation;Genomics;Human;Human Development;human disease;Human Genetics;human induced pluripotent stem cells;improved;Infrastructure;insight;Knowledge;Label;Machine Learning;Measurement;Measures;member;Messenger RNA;Metabolic;Methods;methylome;Modality;Modeling;mRNA sequencing;multi-ethnic;multimodal data;multimodality;multiple omics;Multipotent Stem Cells;network models;neural;novel;open source;Organism;Organoids;Outcome;Pennsylvania;Performance;Phenotype;Population Heterogeneity;predictive modeling;reconstruction;Regulatory Element;Research Personnel;risk variant;RNA;Role;single cell ATAC-seq;single cell genomics;single cell technology;single molecule;single-cell RNA sequencing;spatiotemporal;stem cell differentiation;Technology;Testing;therapeutic target;Time;transcription factor;transcriptomics;Translating;Translational Research;Universities;Untranslated RNA;Visualization;Washington

PROJECT_TITLE: Defining causal roles of genomic variants on gene regulatory networks with spatiotemporally-resolved single-cell multiomics


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Depression;Dissemination and Implementation Research;HIV/AIDS;Infectious Diseases;Mental Health;Prevention

ORG_CITY: CHICAGO

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Depression is common in people living with HIV (PLWH) and is a significant barrier to optimal engagement in HIV care. The goal of the proposed study is to implement mental health screening and referral to a positive affect skills intervention called ORCHID (Optimizing Resilience and Coping with HIV through Internet Delivery) in Ryan White clinics in Chicago to decrease depression and improve engagement in care. If the implementation is successful and the intervention is effective, the ORCHID program can be disseminated nationwide.

PI_NAMEs: BOURIS, ALIDA M;MOSKOWITZ, JUDITH T. (contact)

PROGRAM_OFFICER_NAME: GORDON, CHRISTOPHER M

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Adherence;Adoption;Affect;Area;care outcomes;Caring;Case Manager;Characteristics;Chicago;Cities;Client;Clinic;Clinical;clinical research site;cluster randomized design;Cluster randomized trial;Collaborations;comorbidity;Consolidated Framework for Implementation Research;coping;Data;Disease Progression;Drug usage;Effectiveness;effectiveness analysis;effectiveness evaluation;effectiveness outcome;effectiveness/implementation study;effectiveness/implementation trial;Ensure;Epidemic;epidemic preparedness;Ethics;Focus Groups;Foundations;Funding;General Population;Goals;HIV;Human immunodeficiency virus test;hybrid type 2 design;hybrid type 2 trial;Hybrids;implementation evaluation;implementation facilitation;implementation framework;implementation outcomes;implementation strategy;improved;Individual;internet delivery;Intervention;intervention effect;Intervention Studies;Knowledge;Link;Maintenance;Medical;Mental Depression;Mental Health;Modeling;negative affect;online delivery;online intervention;Outcome;Participant;Patients;Persons;Pharmaceutical Preparations;pilot test;Preparation;primary outcome;Process;programs;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Research;resilience;Rural;Sampling;screening;secondary outcome;sexual minority men;Site;skills;standard of care;Structure;Substance abuse problem;success;Surveys;System;trial design;United States Health Resources and Services Administration;Viral;Viral Load result;Waiting Lists;Well in self;Work

PROJECT_TITLE: A Stepped Wedge Hybrid Type II Trial of an Online Positive Affect Intervention: Blending Implementation and Effectiveness to Improve HIV Continuum Outcomes in Ryan White Clinics in Chicago


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurosciences

ORG_DEPT: BIOLOGY

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: Project Narrative Outcomes of cerebellar disease or injury range from neurological conditions such as ataxia, dystonia, and tremor to neuropsychiatric conditions, including autism spectrum disorders, schizophrenia, and attention- deficit/hyperactivity disorder. It is vital to delineate the elements of the cerebellar circuit and their connectivity to relate circuit properties to disease. This work will provide insight into the mechanisms underlying cerebellar computations, will provide a foundation to understand how cerebellar dysfunction leads to brain disorders, and will help to identify therapeutic targets.

PI_NAMEs: LACKEY, ELIZABETH  (contact)

PROGRAM_OFFICER_NAME: KIM, JENNY LILY

PROJECT_TERMS: Affective;Anatomy;Ataxia;Attention deficit hyperactivity disorder;autism spectrum disorder;Axon;Behavior;Behavior Control;Biological Models;Brain;Brain Diseases;Cells;Cerebellar Cortex;Cerebellar Diseases;Cerebellum;Cognitive;connexin 36;Coupled;Coupling;Data;Disease;Disinhibition;Dystonia;Electron Microscopy;Electrophysiology (science);Elements;Equilibrium;experimental study;extracellular;Eye Movements;Foundations;Future;Gap Junctions;granule cell;Image;improved;in vivo;Inhibitory Synapse;Injury;insight;Interneurons;Learning;Link;Lobule;Maps;Modeling;Molecular;Morphology;mossy fiber;motor learning;mouse genetics;Mus;Myoepithelial cell;Nervous System Disorder;neural;Neurologic;neuropsychiatric disorder;neuropsychiatry;Outcome;Output;Population;postsynaptic;Presynaptic Terminals;Property;Purkinje Cells;reconstruction;Role;Schizophrenia;Signal Transduction;single nucleus RNA-sequencing;Slice;stellate cell;Structure;Synapses;Target Populations;therapeutic target;Thick;Tremor;Whole-Cell Recordings;Work

PROJECT_TITLE: Circuit Specializations of Cerebellar Molecular Layer Interneurons

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-2 Study Section [NST-2]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Mental Health

ORG_CITY: AUSTIN

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

PHR: PROJECT NARRATIVE Impairments in learning and memory are characteristic of several mental health disorders, including schizophrenia, depression, and post-traumatic stress disorder. As such, there remains an urgent need to understand the brain mechanisms that underlie learning and memory in an effort to aid the development of effective treatment interventions for psychiatric and neurological disorders that require acquisition and maintenance of new behaviors. This program will provide predoctoral and postdoctoral trainees with training in advanced methods used to study learning and memory, including cross-disciplinary experimental approaches, advanced statistical analyses, and computational modeling.

PI_NAMEs: PRESTON, ALISON R (contact)

PROGRAM_OFFICER_NAME: DRISCOLL, JAMIE DANIELLE

PROJECT_TERMS: Learning;Memory;Training

PROJECT_TITLE: Training in Learning and Memory


NIH_SPENDING_CATS: Drug Abuse (NIDA only);Neurosciences;Opioid Misuse and Addiction;Opioids;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Substance Misuse

PHR: Project Narrative The number of infants diagnosed with Neonatal Opioid Withdrawal Syndrome (NOWS) continues to rise, though the full extent of long-term molecular and behavioral changes induced by NOWS is still unknown. Opioids are known modulators of the immune system, and clinical data supports immune dysfunction in patients previously diagnosed with NOWS. This proposal aims to fully characterize the molecular and behavioral manifestations of neuroimmune alterations induced by NOWS, and to investigate the novel pharmacologic application of a microglial-targeting drug in treating symptomology.

PI_NAMEs: FERRANTE, JULIA RENEE (contact)

PROGRAM_OFFICER_NAME: FALCON-MORALES, EDGARDO

PROJECT_TERMS: Acute;Address;Adult;Axon;Behavior;Behavioral;behavioral response;Binding;Biological Assay;Birth;brain tissue;Buprenorphine;career;Cell Physiology;Central Nervous System;Child;Clinical;Clinical Data;Clinical Research;clinically relevant;Communication;cytokine;Data;demographics;density;Development;Developmental Delay Disorders;Developmental Process;Diagnosis;Drug Exposure;Drug Targeting;efficacy evaluation;Environmental Risk Factor;Enzyme-Linked Immunosorbent Assay;Exhibits;Exposure to;Failure;Fellowship;Functional disorder;gastrointestinal;Gene Expression;Genes;glial activation;gliogenesis;Goals;Health;Hospitalization;Hospitals;Hour;Human;Immune;Immune response;Immune system;Immune System Diseases;Immunohistochemistry;Immunomodulators;immunoregulation;improved;in utero;Infant;Infection;infection rate;Inflammation;Inflammatory;inhibitor;Injections;Investigation;Knowledge;Laboratories;Life;Lipopolysaccharides;Long-Term Effects;Longitudinal Studies;Measures;Microglia;Modeling;Molecular;Morphine;Morphology;mouse model;Mus;Neonatal;Neonatal Abstinence Syndrome;neonatal human;Neuroimmune;neuroimmunology;Neurologic;neuronal cell body;new therapeutic target;novel;Opioid;opioid exposure;opioid use;opioid withdrawal;Oral;Patients;Perinatal;perinatal development;pharmacologic;Phenotype;phosphodiesterase IV;Physiological;postnatal;Pre-Clinical Model;preclinical study;Pregnancy;Pregnant Women;prevent;Proteins;Public Health;Research;Research Personnel;response;Risk;Rodent;Role;standard care;success;Symptoms;Techniques;Therapeutic;therapeutic target;Thermal Hyperalgesias;Training;Transcript;Ultrasonics;United States;vocalization;Weight Gain;Withdrawal;Withdrawal Symptom;Writing

PROJECT_TITLE: Investigation of acute and long-term neuroimmune changes induced by early-life opioid exposure and withdrawal


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine

ORG_CITY: CHAMPAIGN

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

PHR: NARRATIVE Rotator cuff tears in the shoulder occur at the fibrocartilage interface that connects tendon to bone. While the tendon and bone can be surgically reattached, the interface does not heal, leaving the rotator cuff susceptible to re-failure. This project will develop and thoroughly characterize a stratified biomaterial to guide functional repair of the fibrocartilage interface linking tendon and bone.

PI_NAMEs: HARLEY, BRENDAN A. (contact)

PROGRAM_OFFICER_NAME: MARQUITZ, ARON

PROJECT_TERMS: Acceleration;Address;Adopted;Affect;Allogenic;Autologous;Benchmarking;Biocompatible Materials;biomaterial interface;Bioreactors;bone;Cell Differentiation process;Cells;Cicatrix;Clinical;clinical translation;Collagen;Data;demographics;density;design;differentiation in vitro;Extracellular Matrix;fabrication;Failure;Fibrocartilages;Financial Hardship;Functional Regeneration;Gelatin;Harvest;Histology;Hydrogels;Immunohistochemistry;Implant;implantation;improved;In Situ Hybridization;In Vitro;in vivo;in vivo Model;Injury;innovation;insight;Kinetics;Link;Measures;mechanical properties;Mechanical Stimulation;Mechanics;mesenchymal stromal cell;mimetics;Modeling;Morphology;Musculoskeletal;Natural regeneration;Nature;Operative Surgical Procedures;Pain;Pattern;Peptide Signal Sequences;Performance;Periodicity;Phase;Phenotype;Population;Predisposition;Process;Quality of life;Rattus;regeneration potential;regenerative;repaired;response;Rotator Cuff;rotator cuff injury;rotator cuff tear;scaffold;Shoulder;Site;Source;standard of care;Stimulus;Stress;Structure;Tendon Injuries;Tendon structure;Tissues

PROJECT_TITLE: Stratified and mechanically-tough biomaterial implant to improve tendon-to-bone enthesis regeneration

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]


ORG_CITY: LINCOLN

ORG_NAME: NEBRASKA ST DEPARTMENT OF AGRICULTURE

ORG_STATE: NE

PHR: NDA’s Continued Implementation of FDA’s Produce Safety Rule in Nebraska- Path B PAR-21-174  Project Narrative The Nebraska Department of Agriculture Produce Safety Program (NDA PSP) project entitled “NDA’s Continued Implementation of FDA’s Produce Safety Rule in Nebraska – Path B” is intended to continue to enhance produce safety and maintain a high rate of compliance with the FDA’s Produce Safety Rule through a regulatory program focused on quality and consistency; education and outreach to Nebraska’s producers; and multi-level coordination to support a national Integrated Food Safety System (IFSS).

PI_NAMEs: ANDREWS, CAITLYN  (contact)

PROGRAM_OFFICER_NAME: SCHMIDT, ANDREA

PROJECT_TITLE: Path B NDA's Continued Implementation of FDA's Produce Safety Rule in Nebraska


ORG_CITY: MONTPELIER

ORG_STATE: VT

PHR: Project Narrative Project Title: Vermont Agency of Agriculture, Food & Markets Produce Program Development - PATH C This project supports the Vermont Produce Program's mission to enhance produce safety and protect public health by providing education, outreach, and technical assistance to all Vermont produce farms with produce sales and by achieving and sustaining high rates of compliance with FDA’s Produce Safety Rule among farms covered by the Rule. The goals and objectives of this project build upon the Produce Program’s initial five-year cooperative agreement program (CAP) partnership with FDA in implementing a produce safety regulatory program with a focus on quality and national consistency. The Vermont Agency of Agriculture’s application is made under Path C, and funding is requested for Education and Inventory Band 6 and Regulatory Band 10.

PI_NAMEs: DIEGO, TUCKER  (contact)

PROJECT_TITLE: Path C Vermont Agency of Agriculture, Food & Markets Produce Program Development


ORG_CITY: SALEM

ORG_NAME: OREGON STATE DEPARTMENT OF AGRICULTURE

ORG_STATE: OR

PHR: Project Narrative The Oregon Department of Agriculture (ODA) project entitled: Oregon Department of Agriculture’s Cooperative Agreement for Continued Implementation of a Produce Safety Program under Path A intends to build upon the current Produce Safety Program in Oregon over the next five years by providing education, outreach and technical assistance to produce farms in Oregon while continuing to build Oregon’s farm inventory. The project will utilize federal funds in accordance with the objectives in FOA PAR-21-174. Efforts funded through this project will help produce farms in Oregon comply with the Produce Safety Rule, thereby reducing the likelihood of foodborne illness from fresh produce grown, harvested, packed or held on Oregon operations and support further integration into a national Integrated Food Safety System.

PI_NAMEs: PEARLSTEIN, SUSANNA  (contact)

PROGRAM_OFFICER_NAME: HOEHNA, SHANNON

PROJECT_TITLE: Path A Oregon Department of Agriculture's Cooperative Agreement for Continued Implementation of a Produce Safety Program


ADMINISTERING_IC: VA

FUNDING_MECHANISM: OTHERS

IC_NAME: Veterans Affairs

ORG_CITY: EAST ORANGE

ORG_NAME: VA NEW JERSEY HEALTH CARE SYSTEM

ORG_STATE: NJ

PHR: Parkinson’s disease (PD) is a debilitating and progressive neurodegenerative disorder that disproportionately affects Veterans. The biggest non-hereditary risk factor for developing PD is mild traumatic brain injury (mTBI). mTBI is a non-penetrating jolt, bump, or hit to the head that may result in a brief loss of consciousness, dizziness, nausea, vomiting and headaches. These types of injuries can be sustained repeatedly during basic training or in combat situations and they increase the risk of developing PD later in life. We will determine if TBI accelerates PD in a cutting-edge rat PD model. Exercise provides neuroprotection and improves recovery after a brain injury. However, exercise has never been evaluated for the prevention of PD. We will determine if exercise together with a new class of pharmacological therapeutics that are entering human trials for diagnosed PD, can prevent PD in at risk populations.

PI_NAMEs: DELIC, VEDAD  (contact)

PROJECT_TERMS: Acceleration;Affect;age related;alpha synuclein;Animal Disease Models;Animals;Appearance;Area;Autophagocytosis;Behavioral;Biological;Brain;Brain Injuries;Brain region;Clinic;Clinical;Clinical Trials;combat;combat zone;Deterioration;Development;Diagnosis;disease model;Disease Progression;Dizziness;dopaminergic neuron;early onset;Effectiveness;environmental enrichment for laboratory animals;Equilibrium;Event;executive function;Exercise;Exercise Test;Experimental Designs;Fiber;Frequencies;Future;gain of function;Gait;genome wide association study;Head;Headache;Health;Healthcare Systems;high risk;Histologic;Histopathology;Human;Idiopathic Parkinson Disease;Impairment;improved;In Vitro;in vivo;Inflammation;inhibitor;Injections;Injury;K-Series Research Career Programs;Knock-out;Length of Stay;Lesion;Lewy Bodies;Life;Link;locomotor deficit;LRRK2 gene;Measures;Metabolic;Methods;middle age;mild cognitive impairment;mild traumatic brain injury;Mitochondria;Modeling;Modernization;Molecular;Morbidity - disease rate;mortality;mutant;Mutation;Nature;Nausea;Nerve Degeneration;Nerve Growth Factor Receptors;Neurodegenerative Disorders;neuroinflammation;neuropathology;neurophysiology;neuroprotection;Neurotoxins;neurotrophic factor;New Jersey;non-genetic;older patient;Outcome Measure;oxidative damage;palliative;Parkinson Disease;pars compacta;Pathologic;Pathology;Pathway interactions;Patients;Pharmaceutical Preparations;pharmacologic;Pharmacological Treatment;Pharmacotherapy;Phenotype;Phosphotransferases;Physical therapy;Populations at Risk;Pre-Clinical Model;preclinical study;prevent;Prevention;progressive neurodegeneration;Protein Family;Proteins;Protocols documentation;Rattus;Recovery;Rehabilitation therapy;Reporting;Rest Tremor;Risk;Risk Factors;Rodent;sedentary;Skull Fractures;Substantia nigra structure;Synapses;TBI Patients;Testing;Therapeutic;Time;trafficking;Training;Translating;Traumatic Brain Injury;treatment strategy;Unconscious State;Veterans;Vomiting;Vulnerable Populations;white matter

PROJECT_TITLE: Exercise and pharmacological LRRK2 inhibition for preventing PD

STUDY_SECTION_NAME: Career Development Program - Panel I[RRD8]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Digestive Diseases;Genetics;Human Genome;Orphan Drug;Pancreatic Cancer;Rare Diseases

ORG_CITY: OMAHA

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

PHR: Project Narrative Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease with a five-year survival rate of less than 10 percent, largely due to a lack of any effective therapy. Numerous studies have implicated pyrimidine nucleotide synthesis as a critical metabolic pathway for PDAC cell proliferation and viability; however, inhibitors of DHODH, a key enzyme in this pathway, have consistently failed to show efficacy as monotherapy in various cancer settings. Using a high throughput small molecule screen, we have identified a hit compound that can restore sensitivity to DHODH inhibition in PDAC cell lines that are inherently resistant; this project aims to uncover the mechanism by which this compound overcomes resistance to DHODH inhibition and test the in vivo efficacy of combination therapy, with the ultimate goal of nominating a novel PDAC treatment strategy.

PI_NAMEs: MULLEN, NICHOLAS JAMES (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: Abraxane;Address;Affect;Agammaglobulinaemia tyrosine kinase;American;Anabolism;Animal Model;anti-cancer treatment;Antineoplastic Agents;Automobile Driving;base;Biochemical;Biological Assay;cancer cell;Cancer Etiology;cancer type;Cell Line;Cell Proliferation;Cell Survival;Cells;Cessation of life;chemotherapy;Clinical;Clinical effectiveness;Clinical Trials;combat;combinatorial;Combined Modality Therapy;Deoxyribonucleosides;Dependence;deprivation;design;Dihydroorotate dehydrogenase;Dihydroorotate Dehydrogenase Inhibitor;Disease;Down-Regulation;Drug Combinations;Drug Compounding;Drug Targeting;Drug usage;effective therapy;Effectiveness;efficacy evaluation;efficacy testing;enzyme pathway;Enzymes;experimental group;experimental study;FDA approved;Follow-Up Studies;Genes;Genetic;Genetic Transcription;genotoxicity;Glucose;Goals;Harvest;Human;Hyperactivity;Immune response;Immune system;Immunocompetent;Immunocompromised Host;Implant;implantation;improved;In Vitro;in vivo;in vivo evaluation;inhibitor;inorganic phosphate;Isotope Labeling;kinase inhibitor;Label;Malignant neoplasm of pancreas;Malignant Neoplasms;Mediating;Metabolic;Metabolic Pathway;metabolic phenotype;Metabolism;metabolomics;Monitor;mouse model;Mus;novel;Nucleosides;Nucleotide Biosynthesis;nucleotide metabolism;Nucleotides;Nutrient;Oncogenic;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;Pathway interactions;Patients;Pattern;Pharmaceutical Preparations;Pharmacotherapy;Phosphorylation;Phosphotransferases;Population;pre-clinical;Process;Proliferating;Proteins;Pyrimidine;Pyrimidine Nucleosides;Pyrimidine Nucleotides;Quality of life;Resistance;resistance mechanism;response;Ribose;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Site;small molecule;Solid;standard of care;Survival Rate;System;targeted treatment;Toxic effect;transcriptome sequencing;transcriptomics;Treatment Efficacy;treatment strategy;tumor;tumor growth;tumor microenvironment;tumor progression;Tumor Tissue;Tumor-infiltrating immune cells;Tyrosine Kinase Inhibitor;uptake;Validation

PROJECT_TITLE: Targeting pyrimidine biosynthesis in pancreatic ductal adenocarcinoma


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Clinical Research;Data Science;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE This Clinical and Translational Sciences Award (CTSA) at University of Wisconsin-Madison (UW) supports innovation, training and development of evidence-based approaches to speed effective interventions into health and health care. We propose strategies to engage diverse trainees and underrepresented populations in the conduct, design and rigorous testing of interventions that are effective for all. Project Narrative Page 272

PI_NAMEs: BRASIER, ALLAN R. (contact);BURNSIDE, ELIZABETH S

PROGRAM_OFFICER_NAME: GANNOT, GALLYA

PROJECT_TERMS: Abbreviations;Acceleration;Address;Adopted;Adoption;anti-racism;Bibliography;Clinic;Clinical and Translational Science Awards;clinical practice;Clinical Research;Collaborations;college;Communities;community collaboration;community engagement;Community of Practice;County;COVID-19;COVID-19 pandemic;Data;data interoperability;Data Science;data sharing;data to knowledge;design;Development;Dimensions;Discipline;Disease;Dissemination and Implementation;dissemination science;Ecosystem;effective intervention;Electronics;empowerment;Engineering;equity, diversity, and inclusion;Ethnic Population;evidence base;Evidence based intervention;experience;Extramural Activities;Faculty;Funding;Growth;Health;health care delivery;health equity;health inequalities;Health system;health training;Healthcare;Human Resources;implementation science;improved;Individual;Informatics;Information Systems;Infrastructure;innovation;Institution;interdisciplinary approach;interoperability;Intervention;Leadership;medical schools;Mentors;Mentorship;Methods;Minority Groups;Modeling;National Center for Advancing Translational Sciences;Needs Assessment;novel;Patient Recruitments;Pharmacy Schools;Positioning Attribute;Public Health;Public Health Informatics;Registries;Reproducibility;Research;Research Institute;Research Personnel;resilience;School Nursing;Schools;Science;Scientist;Secure;Site;skills;Speed;Strategic Planning;Students;success;System;systemic intervention;Testing;Training;translational engagement;Translational Research;Trust;Underrepresented Populations;Universities;Veterinary Medicine;Veterinary Schools;Wisconsin;Workforce Development;working group

PROJECT_TITLE: University of Wisconsin Institute for Clinical and Translational Research


NIH_SPENDING_CATS: HIV/AIDS;Infectious Diseases

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Despite the importance of tissue macrophages as an HIV reservoir, the molecular mechanisms of HIV infection in these cells are much less understood. We have identified cyclin L2 as a critical factor that promotes HIV replication in macrophages. In this proposal we will determine how the protein interactions between cyclin L2, the dual specificity kinase DYRK1A and the SAM domain and HD domain-containing protein 1 (SAMHD1) regulate HIV infection in macrophages.

PI_NAMEs: KYEI, GEORGE  (contact)

PROGRAM_OFFICER_NAME: NOVAK, LEIA KAYE

PROJECT_TERMS: C-terminal;CD4 Positive T Lymphocytes;cell type;Cells;Complex;Cyclins;Data;Dissection;Goals;HIV;HIV Infections;HIV-1;HIV-2;Hour;Infection;knock-down;Knock-out;Macrophage;Mass Spectrum Analysis;Mediating;Molecular;molecular domain;monocyte;Mutagenesis;mutant;novel;Nucleotides;Pathway interactions;Phosphorylation;Phosphorylation Site;Phosphotransferases;prevent;Production;Proteins;Rest;SAM Domain;self-renewal;Specificity;therapeutic target;Tissues;Transcript;Tyrosine Phosphorylation;Viral;Virus;Virus Diseases

PROJECT_TITLE: Protein interactions regulating HIV replication in macrophages


NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Dietary Supplements;Digestive Diseases;Genetics;Heart Disease;Human Genome;Microbiome;Nutrition;Precision Medicine;Prevention

ORG_CITY: SAN FRANCISCO

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE The clinical and economic relevance of the role of the gut microbiome in drug outcomes is potentially immense; prescription drugs represent ~10% of national healthcare costs each year, with heart disease representing one of the most expensive and challenging forms of treatment. We will continue to elucidate the mechanisms through which the gut microbiome shapes drug metabolism and disposition, enabling our long-term goal of optimizing treatment outcomes by pairing microbiome-based diagnostic tests and dietary supplements. These findings could have profound implications for pharmacology, emphasizing the need for a comprehensive view of the host and microbial factors that shape the treatment of human disease.

PI_NAMEs: TURNBAUGH, PETER JAMES (contact)

PROGRAM_OFFICER_NAME: DESVIGNE-NICKENS, PATRICE

PROJECT_TERMS: Abbreviations;ABCB1 gene;absorption;Acceleration;Actinobacteria class;Address;Analytical Chemistry;Area;Arginine;Bile Acids;Biochemical;Biochemistry;Biological Availability;Cardiac;Cardiac Glycosides;Cells;Cellular Assay;Clinical;cohort;Cohort Studies;comparative genomics;Complement;Complex;Controlled Study;Coupled;Development;Diagnostic tests;Diet;dietary;dietary supplements;Digoxin;Disease;Dopamine;drug disposition;Drug Efflux;Drug Kinetics;drug metabolism;Drug Prescriptions;Economics;Environmental Risk Factor;Enzymatic Biochemistry;Enzymes;Fractionation;Future;Genes;Genetic;Genomics;Germ-Free;Gnotobiotic;Goals;gut bacteria;gut microbes;gut microbiome;Health;Health Care Costs;Heart Diseases;Heart failure;high throughput screening;Human;human disease;Human Microbiome;immunoregulation;In Vitro;in vitro Assay;Inflammatory;inhibitor;insight;interdisciplinary approach;Interdisciplinary Study;interest;intestinal epithelium;Intestines;Knockout Mice;Knowledge;large scale data;Literature;Liver;Measures;Medicine;Metabolism;metabolomics;Methods;microbial;microbiome;microbiome research;Modeling;mouse model;murine colitis;Mus;Operon;Oral Administration;Outcome;Oxidoreductase;Pharmaceutical Preparations;pharmacokinetic model;Pharmacology;Pharmacotherapy;Physiological;polyphenol;Population;Positioning Attribute;Pre-Clinical Model;precision medicine;prevent;programs;Proteins;Research;Role;Severities;Shapes;small molecule;steroid hormone;Testing;Translating;treatment optimization;Treatment outcome;Variant;Work;World Health Organization

PROJECT_TITLE: Predicting and preventing drug metabolism by the human gut microbiome


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cocaine;Drug Abuse (NIDA only);Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: Nashville

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: PROJECT NARRATIVE Cocaine use disorder (CUD) is a devastating syndrome that significantly affects the lives of the individuals that suffer from it. At the core of CUD is dysregulated learning for drug and non-drug rewards that drives maladaptive drug seeking, drug taking in the face of negative consequences, and an overvaluation of drug- associated stimuli. The goal of this project is to define how drug-induced dysregulation in the dopamine system underlies deficits in the processing of rewarding and aversive events in the environment to drive behaviors associated with CUD.

PI_NAMEs: CALIPARI, ERIN  (contact)

PROGRAM_OFFICER_NAME: MOORE, HOLLY MARIE

PROJECT_TERMS: Affect;Animals;Attention;Aversive Stimulus;Behavior;behavior influence;Behavioral;behavioral response;Characteristics;Cocaine;cocaine exposure;cocaine self-administration;cocaine use;Cocaine use disorder;Code;Control Animal;Cues;Data;Desire for food;Development;Disease Progression;Dissociation;Dopamine;dopamine system;Drug Exposure;Emotional;Environment;Event;evidence base;Exhibits;experience;experimental study;extracellular;Familiarity;Female;Fiber;fluorescence imaging;Functional disorder;Goals;Human;Impairment;in vivo;Individual;Learning;Link;maladaptive behavior;male;Measures;Mediating;mesolimbic system;Mus;Negative Valence;neurotransmission;non-drug;novel;Nucleus Accumbens;Optics;optogenetics;Pattern;Pharmaceutical Preparations;Photometry;Play;Positive Valence;Process;Psychological reinforcement;Punishment;recruit;reinforcer;Resistance;response;reward processing;Rewards;Rodent;Role;sensor;Series;Severities;Shock;Signal Transduction;Speed;Stimulant;Stimulus;stimulus processing;Substance Use Disorder;Sucrose;Symptoms;Syndrome;System;Techniques;theories;Therapeutic;tool;Treatment outcome;Withdrawal

PROJECT_TITLE: Mechanisms of dopaminergic dysfunction in substance use disorder


ADMINISTERING_IC: EY

ED_INST_TYPE: SCHOOLS OF OPTOMETRY/OPHT TECH

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences

ORG_CITY: NEW YORK

ORG_NAME: STATE COLLEGE OF OPTOMETRY

PHR: NARRATIVE Human vision depends on the functional integrity of two major information pathways that originate at the very first synapse of the visual brain and signal the presence of light and dark stimuli in visual scenes, the ON and OFF pathways. Recent results from our laboratory indicate that loss of visual acuity under low light or optical blur affects the cortical circuitry of the ON pathway more than the OFF pathway. They also demonstrate that the ON pathway is more vulnerable to visual diseases that compromise visual spatial resolution such as amblyopia. In this proposal, we will investigate the relative contribution from ON and OFF pathways to human luminance perception and will develop new diagnostic tools to measure ON and OFF visual function and guide treatments in visual disease.

PI_NAMEs: ALONSO, JOSE MANUEL (contact)

PROGRAM_OFFICER_NAME: FLANDERS, MARTHA C

PROJECT_TERMS: Affect;Age;Algorithms;Amblyopia;Animal Model;Animals;area striata;Blindness;Brain;Brain imaging;brain pathway;Clinic;Cone;Contralateral;Darkness;density;Depth Perception;detector;Development;Diagnostic;diagnostic tool;Disease;Disease Progression;Electrophysiology (science);Environment;Equation;Eye;Felis catus;fly;Glaucoma;Goals;head mounted display;Human;human model;Image;image processing;imaging modality;improved;Ipsilateral;Kinetics;Knowledge;Laboratories;Laws;Light;luminance;Measurement;Measures;Modeling;Monitor;Motion;Mus;Neurons;neurotransmission;novel;novel diagnostics;novel marker;Optics;orientation selectivity;Output;Pathway interactions;Patients;Perception;Perimetry;Phase;preservation;Process;Psychophysics;Research;Resolution;response;Retina;Retinal Cone;retinal imaging;Rod;Sampling;segregation;Signal Pathway;Signal Transduction;spatiotemporal;statistics;Stimulus;Synapses;Testing;Textbooks;Variant;Vertebrate Photoreceptors;Vision;Visual;Visual Acuity;Visual Cortex;Visual Fields;visual information;Visuospatial;Weber Fechner Law;Work

PROJECT_TITLE: Functional connectivity in primary visual cortex

STUDY_SECTION: SPC

STUDY_SECTION_NAME: Mechanisms of Sensory, Perceptual, and Cognitive Processes Study Section[SPC]


NIH_SPENDING_CATS: Breastfeeding, Lactation and Breast Milk;Clinical Research;Clinical Trials and Supportive Activities;Microbiome;Nutrition;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention

ORG_CITY: BIRMINGHAM

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE Premature infants born at the limits of viability usually do not grow well during their hospital stay and have a higher risk of developing long-term nutritional complications related to extreme prematurity. Early administration of protein-enriched human milk diets could improve growth by promoting lean body mass accretion, stimulating maturation of gastrointestinal tract, and modifying the gut microbiome. We will test whether protein-enriched human milk diets during the first 2 weeks after birth in premature infants born at the limits of viability result in more lean body mass accretion and more diversity of the gut microbiome by the time of hospital discharge.

PI_NAMEs: SALAS, ARIEL  (contact)

PROGRAM_OFFICER_NAME: ROSS, SHARON A

PROJECT_TERMS: Acceleration;Active Learning;Advisory Committees;Age;Air;Birth;Body Composition;career;career development;Clinical;Clinical Research;Critical Illness;critical period;Data;design;Development;Development Plans;Diet;Dietary Intervention;Enteral Feeding;Enteral Nutrition;evidence base;experience;extreme prematurity;Failure;Fatty acid glycerol esters;Foundations;Future;gastrointestinal;Gastrointestinal Diseases;Gastrointestinal tract structure;Goals;Growth;gut dysbiosis;gut microbiome;Head circumference;Health;high risk;Hospitals;Human;Human Milk;improved;individual response;innovation;insight;Knowledge;Lead;lean body mass;Length;Length of Stay;Life;longitudinal analysis;Measures;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Multi-Institutional Clinical Trial;Neonatal;neurodevelopment;novel;novel marker;novel therapeutics;Nutrient;Nutritional;Nutritional Study;Outcome;Pathogenesis;patient oriented research;Pattern;pilot trial;Plethysmography;postnatal;precision nutrition;Pregnancy;Premature Infant;prevent;programs;protein intake;Proteins;Randomized;randomized trial;Records;recruit;Reporting;Research;research and development;Research Methodology;Research Priority;Research Project Grants;response;Risk;Scientist;Shapes;skill acquisition;skills;stool sample;Testing;Time;Training;translational study;trial design;United States;United States National Institutes of Health;Weight;Work

PROJECT_TITLE: Early life protein-enriched human milk diets to increase lean body mass accretion and diversity of the gut microbiome in extremely preterm infants: a randomized trial

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Pediatrics Study Section[CHHD-A]


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Colorectal Cancer;Digestive Diseases;Genetics;Immunotherapy;Orphan Drug;Precision Medicine;Rare Diseases

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Colorectal cancer (CRC) remains a significant public health problem and there is an urgent need for new treatments with the development novel biomarker driven therapies and immunotherapies as the most important therapeutic priorities in CRC. The clinical trials in this award have the potential to rapidly translate into new therapeutic strategies that will enhance health and prolong life for numerous patients with advanced CRC. Furthermore, the DNA damage and immune biomarker translational work has the potential to develop innovative future strategies in CRC research and develop novel DNA damage and immunostimulatory therapies to significantly improve clinical outcomes for patients with CRC.

PI_NAMEs: CECCHINI, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: RADAEV, SERGEY

PROJECT_TERMS: Acute;Adenosine Diphosphate Ribose;Alkylating Agents;Alkylating Antineoplastic Agents;Ancillary Study;anti-cancer research;Apoptosis;ATR gene;Award;Base Excision Repairs;Biological Assay;Biological Markers;biomarker driven;biomarker identification;Cancer Hospital;Cancer Therapy Evaluation Program;cancer type;Cell Line;Cells;CHEK1 gene;Clinic;Clinical;Clinical Research;clinical trial implementation;Clinical Trials;Clinical Trials Design;Collaborations;colon cancer cell line;Colorectal Cancer;colorectal cancer progression;colorectal cancer treatment;Critical Pathways;Data;design;Development;Disease;Disease Progression;DNA Damage;DNA Repair;DNA Repair Pathway;DNA replication fork;Dreams;early phase clinical trial;Enrollment;Epigenetic Process;experience;experimental study;Faculty;Futile Cycling;Future;Gamma-H2AX;genomic profiling;Glioma;Goals;Grant;Granzyme;Health;Heterogeneity;Hypermethylation;Immune;immune cell infiltrate;Immune response;Immune system;Immune Targeting;Immunofluorescence Immunologic;immunogenicity;Immunologic Markers;Immunologic Stimulation;Immunology;immunoregulation;immunostimulatory therapy;Immunotherapy;improved;In Vitro;in vivo;Individual;inhibitor;innovation;Innovative Therapy;Instruction;investigator-initiated trial;Lesion;Life;Malignant neoplasm of gastrointestinal tract;Malignant Neoplasms;Measures;Medical Oncologist;Mentors;Mentorship;Methods;MGMT gene;Mismatch Repair;multidisciplinary;Mutation;National Cancer Institute;neoantigens;new therapeutic target;next generation;novel;novel marker;novel therapeutic intervention;novel therapeutics;Oncology;Pathogenesis;Pathway interactions;Patient Agents;Patient-Focused Outcomes;Patients;Pattern;Phase Ib/II Clinical Trial;Phosphorylation;Physicians;Play;Poly(ADP-ribose) Polymerase Inhibitor;Polymerase;Polyps;pre-clinical;predictive marker;Predisposition;Prevalence;Prognostic Marker;promoter;Property;Public Health;repaired;replication stress;Research Personnel;Resistance;response;Role;Sampling;Scientist;Site;skills;Specimen;T-Lymphocyte;targeted treatment;Techniques;temozolomide;Testing;Therapeutic;therapeutic target;Thymine;Tissue Microarray;tool;Training;Translating;tumor;tumor heterogeneity;tumor immunology;tumor microenvironment;tumor-immune system interactions;virtual;Work;Xenograft procedure

PROJECT_TITLE: Immunomodulatory Effects of Targeting DNA Repair with Novel Temozolomide Combinations in Colorectal Cancer

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: La Jolla

ORG_NAME: SALK INSTITUTE FOR BIOLOGICAL STUDIES

PHR: Project Narrative Modifications to DNA and histones, the two main components of chromatin, alter the landscape of the genome and play critical roles in facilitating normal growth and development. Among these modifications, aberrant DNA methylation patterns are associated with numerous developmental defects and diseases, yet how specific patterns of methylation are generated and how they are modulated during development, or in response to the environment, are poorly understood. To address these questions, this proposal focuses on characterizing the functions and locus-specificities of chromatin remodeling factors and other transcriptional regulators that are critical for establishing DNA methylation patterns and regulating gene expression.

PI_NAMEs: LAW, JULIE ANN (contact)

PROGRAM_OFFICER_NAME: CHOW, CHI-WING

PROJECT_TERMS: Aberrant DNA Methylation;Address;Affect;Animals;Arabidopsis;Biochemical;biochemical tools;Biological Models;Biological Process;Boundary Elements;Cell Physiology;cell type;Cells;Chemicals;Chromatin;chromatin modification;Chromatin Remodeling Factor;Complex;complex IV;Cytosine;Data;Defect;Deposition;Development;Developmental Process;Disease;DNA;DNA Methylation;DNA-Directed RNA Polymerase;Elements;Ensure;Environment;Epigenetic Process;epigenetic regulation;epigenome;epigenomic profiling;epigenomics;experimental study;Family;Gene Expression;Gene Expression Profile;Gene Expression Regulation;Gene Silencing;Generations;Genetic;Genetic Materials;Genetic Transcription;Genome;genome wide methylation;genome-wide;genome-wide analysis;genomic tools;Growth and Development function;Health;Histones;Homeostasis;Human;Immunoprecipitation;imprint;Individual;insight;Lead;Link;Malignant Neoplasms;Mammals;Maps;Mass Spectrum Analysis;Methylation;methylation pattern;Modeling;Modification;Mouse-ear Cress;mutant;novel;Organism;Pathway interactions;Pattern;Plant Model;Plants;Play;Polymerase;Positioning Attribute;predictive modeling;preference;prevent;Process;Production;Progressive Disease;Property;Protein Family;Proteins;Reading;recruit;Regulation;response;Role;Site;Small Interfering RNA;Source;Specificity;Speed;System;Techniques;Testing;Tissues;Work

PROJECT_TITLE: Establishment and Modulation of DNA Methylation Patterns in Arabidopsis

STUDY_SECTION: MGB

STUDY_SECTION_NAME: Molecular Genetics B Study Section[MGB]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Rare Diseases

ORG_CITY: BALTIMORE

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: NARRATIVE This research proposal is designed to optimize the speed of a novel quantitative CEST MRI technique to a clinical timeframe and to evaluate the accuracy of this technique for identifying active tumor within heterogeneous gliomas. This would allow more precise biopsy sampling of the tumor core, and differentiate active recurrent tumor from treatment effects, which could eventually help to delay or avoid surgery, e.g., where tissue sampling is only for diagnosis.

PI_NAMEs: HEO, HYE YOUNG  (contact)

PROGRAM_OFFICER_NAME: BARRY, ROBERT LEO II

PROJECT_TERMS: 3-Dimensional;Acceleration;Amides;Biopsy;Biopsy Specimen;Brain Neoplasms;Chemicals;Clinic;Clinical;clinical diagnosis;clinical practice;Consumption;convolutional neural network;deep learning;deep learning algorithm;deep learning model;deep neural network;design;detection limit;detection sensitivity;Development;Diagnosis;Fingerprint;Frequencies;Genetic Status;Glioma;healthy volunteer;human subject;Image;imaging modality;Imaging Techniques;Imaging technology;improved;Knowledge;large-scale database;Magnetic Resonance Imaging;Malignant neoplasm of brain;Measurement;Measures;Methods;Molecular;Monitor;novel;Operative Surgical Procedures;patient stratification;Patients;Peptides;personalized therapeutic;Property;Proteins;Protocols documentation;Protons;quantitative imaging;radio frequency;radiological imaging;reconstruction;Recurrent tumor;Relaxation;Reproducibility;Research Proposals;Scanning;Schedule;Scheme;Signal Transduction;solute;Speed;Standardization;Techniques;Technology;Testing;Time;Tissue Sample;Tissues;Training;translational goal;treatment effect;treatment response;tumor;tumor heterogeneity;Variant;Water;Work

PROJECT_TITLE: Chemical Exchange Saturation Transfer MR Fingerprinting

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]