NIH_SPENDING_CATS: Aging;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Human Genome;Infectious Diseases;Influenza;Lung;Pneumonia and Influenza;Prevention;Regenerative Medicine

ORG_CITY: CHICAGO

ORG_DEPT: PATHOLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: Summary Influenza virus epidemics result in severe illness, hospitalizations, and deaths, especially among elderly people. To better understand aging related mechanisms in host defense to respiratory viral infection, we will use cutting- edge technology to decipher cellular locations and cell-cell interactions amongst heterogeneous cells in the lung, which enables a broad overview of interactions among various immune, endothelial, and epithelial cells. We anticipate that our project will identify potential targets for the development of new therapeutic strategies to prevent and treat severe flu symptoms in elderly people.

PI_NAMEs: CUI, WEIGUO  (contact)

PROGRAM_OFFICER_NAME: BOZICK, BROOKE ALLISON

PROJECT_TERMS: Acceleration;adaptive immune response;Affect;Age;age group;age related;aged;Aging;aging mechanism;aging population;Algorithms;anti-influenza;Atlases;Biological;Blood Coagulation Disorders;Body System;CD8-Positive T-Lymphocytes;Cell Communication;Cell Differentiation process;cell type;Cells;Cessation of life;chemokine;clinically relevant;Coagulation Process;Computational algorithm;Computer Analysis;COVID-19 pandemic;Development;Elderly;Endothelial Cells;epidemic virus;Epithelial Cells;Exhibits;Fibrosis;flu;Gene Expression Profile;Genes;Genomics;global health;Hospitalization;Host Defense;Immune;immune function;Immune response;Immune system;immunopathology;Impaired wound healing;Impairment;In Situ;Infection;Infiltration;Inflammaging;Inflammation;Influenza;Influenza A virus;influenza infection;influenzavirus;Injury;Intrinsic drive;Location;Lung;Lymphoid Cell;Methodology;migration;Molecular;mouse model;Mus;Myeloid Cells;Natural regeneration;neutralizing antibody;novel;novel therapeutic intervention;old mice;older adult;Pathway interactions;Persons;Phase;Phenotype;Predisposition;prevent;Prevention strategy;Production;Publishing;Pulmonary Fibrosis;Pulmonary Inflammation;recruit;Recurrence;Research;Resolution;Respiratory Tract Infections;seasonal influenza;senescence;single-cell RNA sequencing;Site;spatial relationship;Structure of parenchyma of lung;Symptoms;Techniques;Technology;Testing;Thrombophilia;tissue injury;tissue repair;Tissues;transcriptome sequencing;treatment strategy;Vascular regeneration;Viral;Viral Respiratory Tract Infection;Virus Diseases;wound healing

PROJECT_TITLE: A spatial sequencing atlas of age-induced changes in the lung during influenza infection

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


ADMINISTERING_IC: CA

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer

ORG_CITY: BOSTON

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: DANA-FARBER CANCER INST

ORG_STATE: MA

PHR: Narrative Recent FDA-approval of new irreversible inhibitors for cancer therapy has renewed interest in drugs which exert their influence via covalent modification of protein targets. However, our inability to accurately assess the full repertoire on- and off-target proteins bound by covalent inhibitors, as well as the inhibitor occupancy of any given target, represent major obstacles to the expansion of covalent drug programs. Herein we develop a new modular platform to rapidly synthesize and test chemical tools for target discovery and target occupancy with the ultimate goal of accelerating development of new covalent inhibitors.

PI_NAMEs: KIM, JUSTIN ;MARTO, JARROD A. (contact)

PROGRAM_OFFICER_NAME: MCKEE, TAWNYA C

PROJECT_TERMS: Acceleration;Alkylation;Amino Acids;Antineoplastic Agents;aqueous;Binding;Binding Proteins;Biological Assay;Biology;biomaterial compatibility;cancer therapy;Cells;Chemicals;Chemistry;chemoproteomics;Clinical Trials;Cysteine;Data;design;Detection;detection limit;Deubiquitinating Enzyme;Development;Diagnostic;Dose;drug candidate;drug discovery;Drug Kinetics;Ensure;experimental study;Future;Generations;Goals;improved;inhibitor;interest;ionization;Ions;Joints;kinase inhibitor;Label;Libraries;Ligation;Link;Malignant Neoplasms;Mass Spectrum Analysis;Methods;novel strategies;Output;Peptides;Performance;Pharmaceutical Preparations;Post-Translational Protein Processing;programs;protein aminoacid sequence;Protein Biochemistry;Proteins;Proteome;Proteomics;Reagent;Reporter;Risk;scaffold;Secure;Site;small molecule;small molecule inhibitor;Solubility;stable isotope;success;Synthesis Chemistry;System;Testing;Therapeutic;Tissues;tool;Toxic effect;Toxicology;ubiquitin isopeptidase

PROJECT_TITLE: New Chemical Tools for Covalent Drug Discovery

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 TCRB-D (O1)]


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Cerebrovascular;Clinical Research;Emergency Care;Health Services;Neurosciences;Prevention;Stroke

ORG_CITY: ATLANTA

ORG_DEPT: NEUROLOGY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Stroke is a devastating disease and a major public health burden in the US and worldwide. Evidence-based medical practice depends on rigorous scientific methods conducted in multi-center clinical trials. Funding for NIH Stroke Net Regional Coordinating Stroke Centers (PAR-17-276) provides a mechanism for developing, promoting, and conducting high-quality, multi-site clinical trials focused on key interventions in stroke prevention, treatment, and recovery.

PI_NAMEs: BORICH, MICHAEL ROBERT;FRANKEL, MICHAEL ROSS (contact);WRIGHT, DAVID W

PROGRAM_OFFICER_NAME: MCCARTHY, SEAN PATRICK

PROJECT_TERMS: Acceleration;Accident and Emergency department;Acute;acute stroke;Agreement;Ambulances;Area;base;career;career development;Caring;Clinical;clinical practice;Clinical Research;Clinical Sciences;Clinical Trials;Clinical Trials Network;Collaborations;Communities;Consultations;Data;Data Coordinating Center;data sharing;design;Detection;Development;Discipline;Disease;Early treatment;effective therapy;Eligibility Determination;Emergency Medicine;Enrollment;Ethics;evidence base;Evidence based practice;experience;faculty mentor;Funding;Future;Goals;Hospitals;improved;Individual;Industry;Infrastructure;innovation;Institution;Institutional Review Boards;interest;Intervention;Interview;Leadership;Link;Master of Public Health;Master of Science;Medical;Medicine;member;Methods;Mission;Multi-Institutional Clinical Trial;National Institute of Neurological Disorders and Stroke;Neurology;Neurosciences Research;neurosurgery;outreach program;Outreach Research;participant enrollment;patient screening;Patients;Pediatrics;Peer Review;Pharmacy facility;Populations at Risk;pre-clinical;Prevention;Program Development;programs;Protocols documentation;Provider;provider networks;Public Health;Qualifying;randomized, clinical trials;Recording of previous events;Recovery;recruit;Recurrence;Registries;Rehabilitation therapy;Research;research and development;Research Assistant;Research Personnel;research study;Research Subject Recruitments;Research Subjects;Research Training;Resources;Scientist;screening;Secondary Prevention;Services;Site;skills;Source;Stroke;stroke clinical trials;Stroke prevention;stroke rehabilitation;stroke therapy;stroke trials;StrokeNet clinical trials;StrokeNet trials;success;synergism;telestroke;training opportunity;Translating;Translational Research;United States National Institutes of Health;Work;working group

PROJECT_TITLE: NIH StrokeNet- Regional Coordinating Stroke Centers for year 2023

STUDY_SECTION_NAME: Special Emphasis Panel[ZNS1 SRB-W (17)]


ED_INST_TYPE: OVERALL MEDICAL

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Precision Medicine;Prevention;Rural Health;Social Determinants of Health;Substance Misuse;Telehealth;Tobacco;Tobacco Smoke and Health

ORG_CITY: HOUSTON

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: PROJECT NARRATIVE  Smoking is a significant public health problem that results in over 480,000 premature deaths in the US each year. While many smokers attempt to quit annually, most relapse to smoking within a year, meaning that there is a critical need for better treatments. The objective of this proposal is to estimate the effects of different medication treatment strategies used for both initial smoking cessation and for "rescue therapy" among those who fail to quit or relapse to smoking, which may lead to more personalized smoking cessation treatments.

PI_NAMEs: CINCIRIPINI, PAUL MICHAEL (contact);ROBINSON, JASON D

PROGRAM_OFFICER_NAME: CICCOLO, JOSEPH THOMAS

PROJECT_TERMS: Abstinence;Address;Adult;Age;Anhedonia;Biochemical;Bupropion;Carbon Monoxide;Cessation of life;Characteristics;Chronic Disease;Clinical Trials;Communities;comorbidity;comparative effectiveness;comparative effectiveness trial;Complex;Counseling;craving;Dependence;depressive symptoms;disability;Disparity population;dosage;Dose;Education;Effectiveness;Ensure;Environment;Evaluation;evidence base;Evidence based intervention;experience;Failure;FDA approved;Future;gender minority group;General Population;Heterogeneity;Household;Income;innovation;Medicaid eligibility;Medical;Mental Health;Methods;Moods;negative affect;Nicotine Dependence;nicotine patch;nicotine replacement;Nicotine Withdrawal;optimal treatments;Outcome;Participant;Patient Selection;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;Pharmacological Treatment;Pharmacotherapy;Phase;Population Heterogeneity;premature;primary outcome;Process;Provider;Psychosocial Factor;Public Health;Race;Randomized;Relapse;Rural;rural area;Sampling Studies;secondary outcome;Sequential Multiple Assignment Randomized Trial;Sexual and Gender Minorities;side effect;Smoker;Smoking;smoking abstinence;smoking cessation;Smoking Cessation Intervention;Source;Texas;Time;timeline;Treatment outcome;Treatment Protocols;treatment strategy;trial comparing;trial design;Uninsured;uptake;varenicline;virtual delivery;virtual platform;volunteer;Withdrawal

PROJECT_TITLE: Comparative Effectiveness of Sequential Pharmacotherapeutic Strategies and Virtually Delivered Treatment to Optimize Smoking Cessation

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Microbiome;Nutrition;Pediatric

ORG_CITY: SAN FRANCISCO

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE Randomized controlled trials evaluating presumptive treatment with a broad-spectrum antibiotic among children with uncomplicated severe acute malnutrition (SAM) have found conflicting results, and thus the role of antibiotics in the management of uncomplicated SAM in children without clinical signs of infection is unclear. Here we propose a large-scale individually randomized controlled trial to determine whether azithromycin, which has recently been shown to reduce all-cause mortality in children aged 1-59 months, is superior to amoxicillin or placebo in children with SAM. We anticipate that the results of this study will provide definitive evidence of the role of antibiotics (including both azithromycin and amoxicillin) in the management of uncomplicated SAM and provide additional insight into whether presumptive antibiotic therapy is helpful for recovery in these children.

PI_NAMEs: OLDENBURG, CATHERINE ELIZABETH (contact)

PROGRAM_OFFICER_NAME: MOYE, JACK

PROJECT_TERMS: Acute;Africa South of the Sahara;aged;Amoxicillin;Antibiotic Resistance;Antibiotic Therapy;Antibiotics;Area;Azithromycin;Burkina Faso;Campylobacter;Cessation of life;Child;Child Care;Child Mortality;Clinical;Communities;Cotrimoxazole;Data;Dose;efficacy evaluation;Enrollment;Equipoise;Etiology;Evaluation;evidence base;follow-up;Genetic;Government;Guidelines;gut dysbiosis;gut microbiome;Half-Life;Health care facility;hospital readmission;Immune system;Immunosuppression;improved outcome;Incidence;Individual;Infant;Infection;infection risk;insight;Malawi;Malnutrition;Morbidity - disease rate;mortality;mortality risk;National Institute of Child Health and Human Development;Niger;Nutritional;Oral;Outcome;Outpatients;Participant;pathogenic bacteria;peer;Persons;Placebos;Policies;Population;population based;prevent;Primary Health Care;Probability;programs;Protocols documentation;Randomized;randomized placebo controlled trial;randomized trial;Randomized, Controlled Trials;Recommendation;Recovery;recruit;relapse prevention;resistome;Role;routine care;Running;Sampling;screening;Subgroup;Tanzania;treatment guidelines;Weight;Weight Gain;World Health Organization

PROJECT_TITLE: Azithromycin as adjunctive treatment for uncomplicated severe acute malnutrition: the AMOUR trial

STUDY_SECTION: ICSC

STUDY_SECTION_NAME: Interdisciplinary Clinical Care in Specialty Care Settings Study Section[ICSC]


NIH_SPENDING_CATS: Brain Disorders;Huntington's Disease;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: BALTIMORE

ORG_DEPT: PSYCHIATRY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Narrative Huntington's disease (HD) is caused by a CAG repeat expansion in the huntingtin (HTT) gene, leading to the pathogenic expansion of a polyglutamine tract in the huntingtin protein. We recently discovered that mutant HTT interacts with NLRP3 protein and activates the NLRP3-imflammasome in HD mouse and human brain tissues, suggesting a role for specific neuroinflammasome pathways in HD pathogenesis. We will investigate these pathways, which may provide novel targets for development of disease-modifying therapeutic strategies.

PI_NAMEs: JIANG, MALI  (contact)

PROGRAM_OFFICER_NAME: MILLER, DANIEL L

PROJECT_TERMS: Activities of Daily Living;Adaptor Signaling Protein;Apoptosis;Astrocytes;Attenuated;Autopsy;Brain;brain tissue;CAG repeat;CASP1 gene;Caspase;Cell model;Cells;chemokine;Clinical Trials;Complex;Corpus striatum structure;cytokine;Development;Disease;disease phenotype;Down-Regulation;drug development;experimental study;Failure;Family;functional restoration;Future;Genes;Human;human disease;human tissue;Huntington Disease;Huntington gene;Immunity;immunoregulation;improved;in vivo;Inclusion Bodies;induced pluripotent stem cell;Induced pluripotent stem cell derived neurons;Infection;Inflammasome;Inflammatory;inhibitor;Innate Immune Response;insight;Intervention;Investigation;knock-down;Knock-in;Knockout Mice;Link;Mendelian disorder;Microglia;Modality;Modeling;Modification;Molecular;mouse model;Mus;mutant;Mutation;Necrosis;Nerve Degeneration;Nervous System Disorder;Neurodegenerative Disorders;neuroinflammation;neuron loss;Neurons;new therapeutic target;Normal tissue morphology;novel;novel therapeutics;overexpression;Pathogenesis;Pathogenicity;Pathologic;Pathology;Pathway interactions;Patients;pharmacologic;Phenotype;Pilot Projects;Plasma;Play;polyglutamine;protein expression;Protein Family;Proteins;receptor;research and development;Role;sensor;Signal Pathway;Signal Transduction;small hairpin RNA;System;T-Lymphocyte;Testing;Therapeutic;therapeutic development;therapeutic target;Time;Tissue Model;Tissues;TNF gene;Transgenic Organisms;treatment strategy

PROJECT_TITLE: Huntingtin links inflammasome pathway in Huntington's disease Pathogenesis

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Immunotherapy;Lung;Lung Cancer;Physical Activity;Prevention

PHR: PROJECT NARRATIVE Only 15-25% patients with lung cancer respond to immunotherapy while more than two thirds of patients experience its side effects. Exercise training yields various physiological changes that can help improve immune function and has the great potential to improve immunotherapy outcomes and reduce its side effects. This multi- level clinical research will explore the mechanisms and efficacy of exercise on immune function and treatment- related outcomes and side effects in patients with lung cancer receiving immunotherapy, which will provide insights of the roles of exercise in immuno-oncology settings and ultimately to improve long-term cancer survivorship in this patient population who are vulnerable yet understudied.

PI_NAMEs: KANG, DONG-WOO  (contact)

PROGRAM_OFFICER_NAME: RADAEV, SERGEY

PROJECT_TERMS: adaptive immunity;Adjuvant;advanced disease;Adverse event;Anti-Inflammatory Agents;anti-PD-1;Antibodies;arm;Award;B-Lymphocytes;Biological Markers;Blood;cancer immunotherapy;Cancer Patient;Cancer Prognosis;Cancer Survivorship;cancer therapy;Cardiopulmonary;career development;CD8-Positive T-Lymphocytes;Cell Proliferation;Cell-Mediated Cytolysis;Cells;Chronic;circulating biomarkers;Clinical;clinical care;Clinical Data;Clinical Research;Clinical Trials;Communities;conditioning;cytokine;Development Plans;Drug usage;Educational Intervention;effective intervention;Endocrine;Exercise;exercise intensity;exercise intervention;exercise prescription;exercise program;exercise training;experience;fitness;follow-up;Foundations;Goals;Grant;Immune;immune cell infiltrate;Immune checkpoint inhibitor;immune function;Immunity;Immunologic Markers;Immunologics;Immunooncology;Immunotherapy;improved;Infiltration;Inflammatory;insight;Interleukin-6;Interval training;Intervention;Knowledge;Lead;Ligands;Lymphocyte;Lymphocyte Count;Malignant neoplasm of lung;Malignant Neoplasms;meetings;Mentorship;Metabolic;Mission;Muscle;Myalgia;Myeloproliferative disease;Natural Killer Cells;Neoplasm Circulating Cells;neoplastic cell;neutrophil;Neutrophil Infiltration;Nivolumab;Non-Small-Cell Lung Carcinoma;novel strategies;Operative Surgical Procedures;Outcome;Patient Care;patient derived xenograft model;patient population;Patient-Focused Outcomes;Patients;Persons;Phagocytes;Phase;phase II trial;Phase III Clinical Trials;Physiological;Pilot Projects;Positioning Attribute;pre-clinical;preclinical study;Prognostic Marker;programmed cell death protein 1;Pulmonary Heart Disease;Quality of life;Randomized;randomized, clinical trials;Regulation;Reporting;Research;Research Personnel;response;Role;Science;Scientific Advances and Accomplishments;senescence;side effect;Stimulus;Survival Rate;Symptoms;T-Cell Proliferation;T-Lymphocyte;Thoracic Oncology;Toxic effect;Training;treatment as usual;treatment response;tumor;Tumor Angiogenesis;Tumor Markers;tumor progression;virtual

PROJECT_TITLE: Harnessing Exercise to Enhance Immunity and Boost Immunotherapy Outcomes in Patients with Lung Cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 RTRB-U (O1)]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_NAME: MICHAEL E DEBAKEY VA MEDICAL CENTER

PHR: Head and neck cancer (HNC) survival among Veterans is low (<65% alive at 5 years post diagnosis) in large part because of the high rate of tobacco exposure that suppressive anti-tumor immunity and reduces treatment response. We hypothesize that adaptation designed to allow HNC tumors to survive oxidative stress de-activates immune cells and prevents them from killing tumor cells. By understanding the mechanisms which support this adaptation we can better risk stratify Veterans with HNC and develop new therapeutic strategies for this deadly disease and other smoking associated malignancies.

PI_NAMEs: SANDULACHE, VLAD C (contact)

PROJECT_TERMS: Acute;Bioinformatics;Biological;biological adaptation to stress;Biological Assay;Cancer Biology;Cancer Model;cancer survival;CD8-Positive T-Lymphocytes;Cell Line;Cells;chemokine;chemoradiation;chemotherapy;Chemotherapy and/or radiation;Chronic;Cisplatin;clinical translation;Clinical Trials;clinically relevant;Combined Modality Therapy;Coupled;CRISPR interference;Cysteine;cytokine;Data;data modeling;defined contribution;design;Diagnosis;Disease;Effectiveness;Epidemic;Epigenetic Process;Event;Excision;Exposure to;Failure;Free Radicals;Gene Activation;General Population;Genetic;Genomics;Glutaminase;GPX2 gene;Head and Neck Cancer;Human Cell Line;human data;Human Papillomavirus;Immune;immune checkpoint;Immune checkpoint inhibitor;Immune system;Immunocompetent;immunodeficiency;Immunooncology;Immunotherapy;improved;In Vitro;in vivo;Incidence;Individual;Infection;Infiltration;inhibitor;Kinetics;Link;Malignant Neoplasms;Measurement;Measures;Mediating;Metabolic;military veteran;mouse model;Mutation;Myeloid-derived suppressor cells;Neoplasm Metastasis;neoplastic cell;Neurofibromin 2;NF-kappa B;novel therapeutic intervention;nuclear factor-erythroid 2;Oncogenic;Operative Surgical Procedures;Outcome;Oxidative Stress;Oxidative Stress Induction;Pathway interactions;patient subsets;Patients;permissiveness;pharmacologic;Pharmacologic Substance;Population;Populations at Risk;pre-clinical;prevent;Production;Prostaglandins;Proteins;Radiation;radiation resistance;radiation response;rapid growth;Regimen;Resistance;response;Risk;risk stratification;Signal Transduction;Smoke;Smoking;Solid Neoplasm;standard of care;stem;T-Lymphocyte;Testing;theranostics;Therapeutic;Time;Tobacco;tobacco exposure;Tobacco use;TP53 gene;transcriptome sequencing;Translating;treatment response;tumor;Tumor Biology;Tumor Immunity;Tumor-Derived;tumor-immune system interactions;Validation;Veterans

PROJECT_TITLE: Activation of immunosupressive oxidative stress response pathways by tobacco exposure in head and neck cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 CAMM-P (01)]


ADMINISTERING_IC: DC

ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: ROCHESTER

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF ROCHESTER

ORG_STATE: NY

PHR: Project Narrative Millions of people suffer from a communication deficit that impairs speech perception. This research proposal investigates how the human brain integrates across time-varying structures such as phonemes and words, which have highly variable durations. Understanding dynamic temporal integration is critical to understanding the neural mechanisms that allow people to perceive speech and their impairments in communication deficits.

PI_NAMEs: NORMAN-HAIGNERE, SAMUEL V (contact)

PROGRAM_OFFICER_NAME: POREMBA, AMY

PROJECT_TERMS: Acoustics;Address;Anatomy;Auditory;Auditory area;auditory processing;Brain;Cognitive;Communication;Computer Models;Computing Methodologies;Coupled;Data;deep neural network;Dimensions;Electrophysiology (science);experimental study;Frequencies;Functional Magnetic Resonance Imaging;Hearing problem;Human;Impairment;innovation;Knowledge;Learning;Link;Literature;Maps;Measures;Methods;millisecond;Modality;Modeling;Nervous System Disorder;neural;neural model;Neural Network Simulation;neuromechanism;neurophysiology;neurosurgery;novel;Patients;Persons;preservation;Psycholinguistics;receptive field;Research;Research Project Grants;Research Proposals;response;Response to stimulus physiology;sound;Speech;Speech Perception;speech processing;speech recognition;Stimulus;Stretching;Structure;Structure of superior temporal sulcus;Superior temporal gyrus;System;Techniques;Testing;theories;Time;Training;Variant;Work

PROJECT_TITLE: Dynamic temporal integration of speech structure in the human brain

STUDY_SECTION: LCOM

STUDY_SECTION_NAME: Language and Communication Study Section[LCOM]


ADMINISTERING_IC: MD

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

ORG_CITY: PONCE

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: PONCE SCHOOL OF MEDICINE

ORG_STATE: PR

PHR: NARRATIVE FOR THE OVERALL RCMI CENTER The present RCMI application intends to expand a comprehensive center for addressing issues impacting minority health and health disparities. Goals and objectives have been designed based on the current strengths and strategic plan of our research enterprise and community engagement. The research strategy is comprised of the implementation and development of five cores and three full research projects, and the activities generated through the proposed center will be evaluated by a multi-component assessment program.

PI_NAMEs: NOEL, RICHARD J. (contact);THOMPSON, KENIRA J

PROGRAM_OFFICER_NAME: SOLIS SANABRIA, CAROLINA VANESSA

PROJECT_TERMS: Address;Advisory Committees;Amygdaloid structure;Area;Asthma;Basic Science;Behavioral;Behavioral Research;Biomedical Research;career;career development;Chronic stress;Clinical;Clinical Research;Cocaine use disorder;Communities;community collaboration;community empowerment;community engagement;community organizations;design;Development;Disease;Disparity population;Doctor of Philosophy;effectiveness evaluation;Environment;Evaluation;Event;experience;Exposure to;extracellular;Extramural Activities;Faculty;Faculty Recruitment;Fostering;Funding;Future;Goals;Health;health disparity;Health Sciences;Health Services Research;health training;improve minority health;improved;innovation;Institution;Intervention;Journals;Knowledge;Leadership;Mainstreaming;Measures;member;Mentors;minority health;minority health disparity;Mission;Modeling;Monitor;Nature;neighborhood disadvantage;neutrophil;novel;novel therapeutic intervention;Nucleus Accumbens;operation;Peer Review;Persons;Pilot Projects;Population;Positioning Attribute;Postdoctoral Fellow;Press Releases;prevent;Probability;Productivity;programs;Publications;Puerto Rico;recruit;Reduce health disparities;Research;Research Activity;research and development;research faculty;Research Infrastructure;Research Personnel;Research Project Grants;Resources;Rodent Model;Role;Science;Seasons;Secure;Series;severe mental illness;sex determination;Sex Differences;social media;Source;Specialized Center;Strategic Planning;Stress;success;SYK gene;Technology;Testing;tool;Training;Translational Research;United States National Institutes of Health;Universities

PROJECT_TITLE: PHSU Specialized Center in Health Disparities

STUDY_SECTION_NAME: Special Emphasis Panel[ZMD1 ML (A1)]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: NOEL, RICHARD J. (contact)

PROJECT_TERMS: Accountability;Address;Administrator;Advisory Committees;Agreement;Applications Grants;Area;Basic Science;Behavioral;Budgets;career;Clinical Management;Clinical Research;Clinical Trials;Collaborations;Communication;Communities;community organizations;conflict resolution;design;Development;Discipline;Educational workshop;Enhancement Technology;Ensure;Equipment;Evaluation;Event;evidence base;expectation;experience;Faculty;Faculty Recruitment;Funding;Funding Opportunities;Goals;Grant Review;Guidelines;health disparity;health inequalities;Health Sciences;higher education;Human;improve minority health;Individual;Infrastructure;innovation;Institution;Joints;Knowledge;Logic;Mainstreaming;Manuscripts;meetings;Mentors;Modeling;Molecular;multidisciplinary;peer;Peer Review;Performance;Philosophy;Policies;Positioning Attribute;Postdoctoral Fellow;Preparation;prevent;Procedures;Process;Productivity;Program Development;Program Evaluation;programs;Qualifying;Reduce health disparities;Regulation;Research;research and development;Research Personnel;Research Project Grants;Resource Development;Resources;Series;Specialized Center;Speed;Strategic Planning;Structure;Teacher Professional Development;Technology Transfer;Time;training opportunity;Translational Research;United States National Institutes of Health;Universities;Update;web page

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Neurosciences;Racial and Ethnic Minority Health Research;Social Determinants of Health

PROJECT_TERMS: Area;Behavioral;Brain;Cancer Biology;candidate selection;Chronic Disease;Communicable Diseases;Compensation;Credentialing;Data Science;design;Development;Discipline;Employee;Employment;Equipment;experience;Faculty;Faculty Recruitment;Funding;Goals;Grant;Guidelines;health disparity;Human Genetics;Human Resources;Institution;Intention;Interview;Laboratories;Mainstreaming;Manuscripts;Mediation;Medicine;member;mid-career faculty;minority health;minority health disparity;Mission;Neurosciences;Oncology;Peer Review;Policies;Positioning Attribute;Postdoctoral Fellow;Procedures;Productivity;Public Health;recruit;Research;research facility;research faculty;Research Personnel;Salaries and Fringe Benefits;Schools;Science;Secure;Specialized Center;Talents;Targeted Research;Teacher Professional Development;Training;United States National Institutes of Health;Wages

PROJECT_TITLE: Recruitment Core


NIH_SPENDING_CATS: Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: JIMENEZ CHAVEZ, JULIO CESAR (contact)

PROJECT_TERMS: Address;Affect;burden of chronic illness;care systems;Characteristics;Chronic;Chronic Disease;cohort;Collaborations;Communication;Communities;community based participatory research;community engaged research;community engagement;Community Health;Community Health Education;community organizations;Community Participation;community partners;community research;community setting;design;Diabetes Mellitus;Early Diagnosis;Education;Educational Curriculum;Educational process of instructing;empowerment;Equity;Fostering;Future;Health;health care quality;Health Disparities Research;health disparity;Health education;health inequalities;Health Insurance;Health Promotion;Healthcare Systems;healthy lifestyle;High Prevalence;Hispanic;Hypertension;Improve Access;improved;Inequality;Inequity;innovation;Insurance Coverage;Intervention;Island;Knowledge;Latino Population;Liquid substance;member;Mental disorders;Mental Health;Mental health promotion;Needs Assessment;Obesity;Outcome;Overweight;patient oriented;Pilot Projects;Population;Poverty;Prevention;Prevention strategy;programs;promoter;Puerto Rican;Research;Research Personnel;Risk Factors;skills;social;social health determinants;Social outcome;Specialized Center;Symptoms;Training;Translating;Translational Research;underserved community;Underserved Population;Unemployment

PROJECT_TITLE: Community Engagement Core


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Cocaine;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurosciences;Prevention;Social Determinants of Health;Stimulant Use and Misuse;Substance Misuse;Women's Health Research

PI_NAMEs: SEPULVEDA-ORENGO, MARIAN TALIMAR (contact)

PROJECT_TERMS: Abstinence;Affect;AMPA Receptors;Amygdaloid structure;Anxiety;Behavior;behavior influence;Behavioral;behavioral response;biological adaptation to stress;Brain;Cells;Chronic stress;Cocaine;cocaine exposure;cocaine related behaviors;cocaine seeking;cocaine self-administration;cocaine use;Cocaine use disorder;comorbidity;Consumption;craving;cue reactivity;Cues;Data;Designer Drugs;Development;Disease;Dose;drug abstinence;Drug abuse;Drug Addiction;Drug usage;Exhibits;experience;experimental study;Exposure to;Female;foot;Gender;gender disparity;Goals;health care disparity;health disparity;Incubated;Laboratories;male;Measures;Medical;men;Mental Depression;Mental disorders;Modeling;N-Methyl-D-Aspartate Receptors;N-Methylaspartate;neural;Neuronal Plasticity;Neurons;neurophysiology;Nucleus Accumbens;optogenetics;Output;patch clamp;Pharmaceutical Preparations;Physiological;Population;Prevention strategy;psychologic;Rattus;receptor;Recording of previous events;Relapse;Research;response;Rewards;Risk Factors;Rodent Model;Role;Self Administration;Series;sex;Sex Differences;Shock;Specialized Center;Stress;stress related disorder;stressor;Structure;Substance Use Disorder;Synapses;Synaptic plasticity;Testing;Trauma;Woman;women versus men

PROJECT_TITLE: Sex Difference in a rodent model of co-occurrence of chronic stress and cocaine use disorder


NIH_SPENDING_CATS: Behavioral and Social Science;Bipolar Disorder;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Mental Illness;Obesity;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Schizophrenia;Serious Mental Illness;Social Determinants of Health

PI_NAMEs: RIVERA-SEGARRA, ELIUT  (contact)

PROJECT_TERMS: Address;Adoption;Attention;barrier to care;Behavioral;behavioral health;Biological;Bipolar Disorder;Body mass index;Cardiovascular Diseases;care coordination;Caribbean region;Caring;Case Manager;Chronic Disease;Clinical Psychology;COVID-19 pandemic;Diabetes Mellitus;disorder prevention;disorder risk;Disparity;Early Intervention;Earthquakes;Effectiveness;effectiveness testing;effectiveness-implementation RCT;Exhibits;follow-up;General Population;Glycosylated hemoglobin A;graduate student;Health;health care availability;health care settings;health disparity;health literacy;Health Sciences;Health Services;Healthcare;Healthcare Systems;Human Resources;Hurricane;Hybrids;improved;internalized stigma;Intervention;intervention delivery;Intervention Studies;Latinx;Latinx population;Light;Lipids;Maintenance;Measures;Medical;Methods;Morbidity - disease rate;mortality;National Institute on Minority Health and Health Disparities;Obesity;Overweight;Participant;Patients;Persons;Physical activity;physical conditioning;physical inactivity;physical symptom;Physicians;Play;Premature Mortality;Prevention;Preventive;Preventive care;Primary Care;Primary Care Physician;primary care services;primary health service;primary outcome;Provider;Public Health;Puerto Rican;Puerto Rico;Randomized;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Research;Risk Factors;Schizophrenia;screening;secondary outcome;Services;severe mental illness;Smoking;social culture;social stigma;Specialized Center;Target Populations;Testing;treatment as usual;United States;Universities;Vaccination;Wait Time;Work

PROJECT_TITLE: Testing Bridges to Better Health and Wellness for People Living with Serious Mental Illness in Puerto Rico


NIH_SPENDING_CATS: Asthma;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: RAMOS-BENITEZ, MARCOS JAVIER (contact)

PROJECT_TERMS: Accounting;Address;Adrenal Cortex Hormones;Affect;airway epithelium;airway inflammation;Animal Model;Asthma;asthma exacerbation;asthmatic patient;Automobile Driving;Biological;Biological Assay;Biology;Blood;cell injury;Child;Chronic;Clinical;Clinical Data;Clinical Management;Clinical Research;Clinical Trials;clinically relevant;cohort;Complement;cytokine;Data;data management;data quality;Development;Disease;Doctor of Philosophy;effective therapy;eosinophil;Ethnic Population;Exhibits;exome;extracellular;Frameshift Mutation;Future;Genetic Screening;genetic variant;Genetic Variation;Genotype;Health Care Costs;health disparity;Health Sciences;Hospitalization;Human;Immune;Immune response;improved;improved outcome;Incidence;Individual;Infection;Inflammation;Inflammatory;Innate Immune Response;innovation;insight;Institution;Knowledge;Link;live cell imaging;Mediating;Mediator;Molecular;Monitor;neutrophil;Neutrophil Activation;Neutrophil Infiltration;novel;obstructive airway disease;Organ failure;Outcome;Pathogenesis;Pathway interactions;patient population;Patients;Persons;Phagocytosis;Phenotype;phosphoproteomics;Phosphorylation;Play;Population;Prevalence;Principal Investigator;Process;Production;programs;Puerto Rican;Puerto Rico;Pulmonology;Reactive Oxygen Species;recruit;Recurrence;Regimen;Reporting;Research;Research Personnel;Resistance;respiratory;response;Role;Sampling;Schedule;Severities;Signal Pathway;Signal Transduction;Specialized Center;Sputum;Stimulus;Subgroup;SYK gene;Symptoms;systemic inflammatory response;Testing;therapeutic target;Time;United States;Universities;Variant

PROJECT_TITLE: Spleen Tyrosine Kinase Inhibition to target Neutrophil Extracellular Traps in Severe Persistent Asthma


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Racial and Ethnic Minority Health Research;Social Determinants of Health

PROJECT_TERMS: Accountability;Address;Advocacy;American;Area;Award;Behavioral;Biomedical Research;care outcomes;career;career development;career networking;Caring;Clinical;cohort;Communities;community collaboration;community engagement;COVID-19 pandemic;cultural competence;data acquisition;Degree program;Development;Development Plans;Disease;Disease Outcome;Diverse Workforce;Educational Curriculum;Educational workshop;Effectiveness;Emerging Communicable Diseases;Ensure;ethnic diversity;ethnic minority;Evaluation;Extramural Activities;Faculty;Fostering;Foundations;Funding;gender minority;Goals;Guidelines;Health;Health Disparities Research;health disparity;Health Sciences;Healthcare;Heart Diseases;improve minority health;improved;Individual;Infection;innovation;Inosine Diphosphate;Institution;investigator training;Investments;Knowledge;Leadership;life span;Link;Malignant Neoplasms;Manuscripts;Medical;member;Mentors;Minority Groups;minority health;minority health disparity;Molds;next generation;novel;novel strategies;parity;Participant;Pathway interactions;peer coaching;personalized health care;Phase;Pilot Projects;Postdoctoral Fellow;Productivity;programs;public health research;Publications;Puerto Rico;Quality of Care;racial diversity;racial minority;recruit;Research;Research Methodology;Research Personnel;Research Project Grants;Research Training;Resources;response;Role;Services;skills;Specialized Center;Structure;Study Section;success;Surveys;System;Training;Training Programs;Trust;Underrepresented Populations;Universities

PROJECT_TITLE: Investigator Development Core


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: RIVERA-AMILL, VANESSA  (contact)

PROJECT_TERMS: Acceleration;Address;Applications Grants;Area;Basic Science;Behavioral Research;Bioinformatics;Biomedical Research;Biometry;career development;catalyst;Clinical;Clinical Research;Collaborations;Communities;community engagement;community research;Data;Data Analyses;Data Science;Data Storage and Retrieval;design;Development;Education;Educational workshop;Environment;Equipment;Ethics;experience;experimental study;Faculty;Fostering;Funding;Funding Agency;Genomics;Goals;Growth;Guidelines;Health;health care disparity;health disparity;Health Sciences;Healthcare;Human Resources;improve minority health;improved;Infrastructure;innovation;Institution;instrument;instrumentation;interdisciplinary collaboration;Island;Leadership;Mentors;Methods;minority health;minority health disparity;minority healthcare;Minority-Serving Institution;Mission;Modernization;next generation sequencing;operation;Outcome;Procedures;Productivity;Public Health;Publications;Reduce health disparities;Research;Research Activity;research and development;Research Infrastructure;Research Personnel;Research Project Grants;Research Support;Resources;responsible research conduct;Science;Scientist;Services;Specialized Center;Specific qualifier value;Strategic Planning;success;synergism;Technology;tool;Training;Training and Education;Training Support;Translational Research;Underserved Population;United States National Institutes of Health;Universities;Update;Vision;Work

PROJECT_TITLE: Research Capacity Core


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE This project will determine the role of prolonged enterovirus infections in triggering the development of autoantibody responses to islet autoantigen targets and the development of Type 1 Diabetes in children under the age of six. We will find additional children within the TEDDY study with prolonged virus infections, analyze antibody responses to enterovirus in plasma samples, we will deeply characterize the global and EV-specific immune response in the PBMCs of these children using single cell gene expression analyses. This study will clarify our knowledge of exactly which virus(es) can trigger the development of IA and T1D disease, when that may occur in early childhood, and provide insights into the mechanisms involved, links to key genetic variants in the children and can lead to preventative strategies in the future.

PI_NAMEs: HYÖTY, HEIKKI ;LLOYD, RICHARD E (contact);LYNCH, KRISTIAN F;MCKINNEY, EOIN ;PETROSINO, JOSEPH FRANK

PROGRAM_OFFICER_NAME: AKOLKAR, BEENA

PROJECT_TERMS: 15 year old;6 year old;Acute;acute infection;Adenovirus Infections;Age;Age of Onset;aged;Anti-viral Response;Antibodies;Antibody Response;Antigen Receptors;Antigens;Autoantibodies;Autoantigens;Autoimmune;Autoimmune Diseases;Autoimmunity;biomarker identification;Birth;Blood specimen;case control;CCL14 gene;Celiac Disease;Cells;Child;Childhood diabetes;clinical center;cohort;Collection;Complex;Country;Data;Detection;Development;Diabetes Mellitus;diabetes pathogenesis;Diagnostic;Disease;Disease Outcome;disorder risk;early childhood;endocrine pancreas development;Enterovirus;Enterovirus Infections;Exposure to;Feces;Finland;Future;Gene Expression Profiling;Genes;Genetic;Genetic Markers;Genetic Risk;Genetic Transcription;genetic variant;genomic data;Genomics;Genotype;Germany;Global Change;Goals;Humoral Immunities;Immune;Immune response;Immunity;Infection;Infectious Agent;innovation;insight;Insulin-Dependent Diabetes Mellitus;International;islet;islet autoimmunity;Knowledge;Leukocytes;Link;Maternal antibody;Modeling;Molecular;multiple omics;nasal swab;Natural Immunity;Neighborhoods;Nested Case-Control Study;novel therapeutic intervention;Pattern;peripheral blood;Peripheral Blood Mononuclear Cell;Plasma;Population;population based;prevent;Prevention strategy;preventive intervention;progression marker;prospective;Prospective cohort;Prospective, cohort study;protein expression;Quantitative Reverse Transcriptase PCR;Recombinants;response;Risk;Role;Sampling;Sequence Analysis;Series;seroconversion;Serology;Serology test;Serotyping;single cell analysis;single cell sequencing;Source;Sweden;System;Time;treatment strategy;United States;Vaccination;Vaccines;Viral;Viral Antibodies;virome;Virus;Virus Diseases;Whole Blood;Work

PROJECT_TITLE: Virome and Immune Responses associated with IA and Type 1 Diabetes

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-S (O3)]


NIH_SPENDING_CATS: Aging;Brain Disorders;Cerebrovascular;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Rural Health;Social Determinants of Health;Stroke

ORG_CITY: SAINT LOUIS

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Stroke is a major public health problem in the United States, where it is the 5th leading cause of death and the leading cause of adult disability. Indeed, there is great need to develop interventions that prevent, treat, or enhance recovery after stroke. We have been honored to be a part of the first cycle within Stroke Net, having successfully grown the Mid-America Regional Coordinating Center (MARCC) at Washington University to include six high-volume tertiary care Stroke Centers spanning MO, KS, IL, TN, MS and AR. We look forward to expanding our network and patient enrollment further in the next Stroke Net cycle to continue to meet the joint goals of this network.

PI_NAMEs: FORD, ANDRIA LEE;PANAGOS, PETER DAVID (contact)

PROJECT_TERMS: Admission activity;Adult;Agreement;Arkansas;Award;Black American;career;career development;Caring;Catchment Area;Cause of Death;Cities;Clinical;Clinical Research;Clinical Trials;Collaborations;Colombia;Communication;Community Healthcare;Data;Data Coordinating Center;data management;design;disability;Enrollment;Equity;evidence base;Exclusion;experience;Fellowship;follower of religion Jewish;Funding;Future;Geography;Goals;Grant;Growth;Health Sciences;Hospitals;Human;Illinois;improved;Individual;Infrastructure;inner city;Institutional Review Boards;Intervention;Joints;K-Series Research Career Programs;Kansas;Lead;Leadership;Medical center;medical schools;Mentors;Mentorship;Midwestern United States;Mission;Mississippi;Missouri;mortality;multidisciplinary;National Institute of Neurological Disorders and Stroke;participant enrollment;participant retention;patient population;Patient Recruitments;Patients;post stroke;Prevalence;prevent;Protocols documentation;Public Health;Race;racial diversity;Recovery;recruit;Research;Research Infrastructure;Research Personnel;Resources;retention rate;rural patients;Rural Population;rural setting;Scientist;Site;skills;socioeconomics;Specialist;Spottings;Stroke;Stroke Belt;stroke clinical trials;stroke patient;stroke trials;StrokeNet trials;Tennessee;tertiary care;Time;Training;Translational Research;Underrepresented Minority;United States;United States National Institutes of Health;Universities;urban setting;Vision;Washington;Work


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Primary Health Care;Social Determinants of Health

ORG_CITY: RICHMOND

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: PROJECT NARRATIVE The National Cancer Institute (NCI) is creating a Cancer Screening Research Network (CSRN) to conduct national randomized controlled trials and longitudinal studies to evaluate new technologies for cancer screening and close critical evidence gaps. To assist in this effort, we propose to create the Virginia CSRN Accrual, Enrollment, and Screening Sites (ACCESS) Hub from long-standing inter-institutional partnerships between three health system, two medical schools, two cancer centers including an NCI-designated comprehensive cancer center, an NIH-funded clinical and translational science center, and a 500+-practice primary care practice-based research network. The Virginia CSRN ACCESS Hub will participate in the proposed Vanguard study – a randomized controlled trial of multi-cancer detection tests – and demonstrate its distinct ability to recruit and retain inclusive and diverse participants onto national cancer screening trials and evaluate factors necessary to broadly disseminate and implement new cancer screening practices.

PI_NAMEs: KALTMAN, REBECCA ;KRIST, ALEXANDER H (contact);NANASINKAM, SERGE PATRICK

PROGRAM_OFFICER_NAME: LEEVAN, ELYSE MICHELLE

PROJECT_TERMS: Academy;Address;Adherence;Adopted;Adoption;Advocate;Ambulatory Care;arm;Cancer Center;Cancer Detection;cancer prevention;care systems;Caring;Catchment Area;Censuses;Center for Translational Science Activities;Cessation of life;clinical center;clinical practice;Clinical Sciences;Clinical Trials;Clinical Trials Design;Collaborations;Communication;Communities;community advisory board;community engagement;Comprehensive Cancer Center;Conduct Clinical Trials;Consolidated Framework for Implementation Research;contextual factors;Controlled Clinical Trials;Data;Data Collection;Data Coordinating Center;data quality;data sharing;design;detection test;Development;Diagnostic;Dissemination and Implementation;dissemination science;Effectiveness;efficacy evaluation;Eligibility Determination;Enrollment;Ensure;Equity;Funding;Future;Health;Health system;Healthcare;implementation science;Informatics;Infrastructure;infrastructure development;innovation;inter-institutional;Interview;lens;Longitudinal Studies;Malignant Neoplasms;marginalization;marginalized population;Measures;medical schools;medical specialties;medically underserved;Medicine;Methods;National Cancer Institute;new technology;novel;novel strategies;Outcomes Research;Participant;participant retention;Patient Participation;Patient Recruitments;Patients;Persons;Population Heterogeneity;Positioning Attribute;practice-based research network;prevent;Prevention;Primary Care;primary care practice;Protocols documentation;Quality Control;Randomized;Randomized, Controlled Trials;Recommendation;Records;recruit;Research;Research Design;Role;routine care;routine practice;Rural;safety net;screening;Screening for cancer;Series;Services;Site;social engagement;statistics;success;Technology;Testing;Translational Research;Treatment Protocols;underserved community;Underserved Population;United States National Institutes of Health;United States Preventative Services Task Force;Universities;Virginia;Work

PROJECT_TITLE: Virginia Cancer Screening Research Network Access Hub (Virginia CSRN Hub)

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-P (O1)]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

PHR: Project Narrative Cancer is a major worldwide health concern where delays in the diagnosis and treatment of cancer lead to increased mortality. The proposed project will enable large-scale artificial intelligence studies using radiomics, deep learning, and physics-based generative modeling in nuclear medicine imaging for the automatic characterization of malignant diseases. The developed approach will be generalizable across a range of cancer types and will help improve patient outcomes by facilitating the early detection, diagnosis, prognosis, and treatment of cancer.

PI_NAMEs: LEUNG, KEVIN HO-YIN (contact)

PROJECT_TERMS: Address;Advisory Committees;Age;Anatomy;Artificial Intelligence;Benign;Biological;biomarker discovery;cancer imaging;Cancer Patient;Cancer Prognosis;cancer therapy;cancer type;Cancerous;Cause of Death;Characteristics;Classification;Clinical;Clinical Data;clinical database;clinical imaging;clinical prognosis;Collaborations;Committee Members;Computer Vision Systems;Data;Data Set;Databases;Decision Trees;deep learning;Detection;Devices;Diagnosis;digital;digital data;Dimensions;Discipline of Nuclear Medicine;Disease;Early Diagnosis;Engineering;Environment;generative models;Glean;Grant;Health;Heterogeneity;High Performance Computing;Image;image reconstruction;imaging biomarker;imaging modality;improved;insight;interest;Knowledge;large datasets;Lead;Learning;Lesion;Logistic Regressions;Machine Learning;machine learning model;Magnetic Resonance Imaging;Malignant - descriptor;Malignant Neoplasms;Manuals;Medical;Medical Device;Medical Imaging;Mentors;Methods;Modality;Modeling;Morphology;mortality;multilayer perceptron;Outcome;Pathology;Patient imaging;patient population;Patient-Focused Outcomes;Patients;Phase;Physicians;Physics;Population;Positron-Emission Tomography;predict clinical outcome;Process;Prognosis;prognostic;prognostication;Progression-Free Survivals;Protocols documentation;Publications;radiological imaging;Radiology Specialty;radiomics;radiotracer;random forest;reconstruction;Reproducibility;Research;Resolution;Resources;Roentgen Rays;Sampling;sex;simulation;Source;Standardization;standardize guidelines;success;support vector machine;task analysis;Techniques;Technology;The Cancer Imaging Archive;tool;Tracer;Training;transfer learning;treatment response;tumor;ultrasound;United States;United States Food and Drug Administration;Universities;uptake;Variant;Visual;X-Ray Computed Tomography

PROJECT_TITLE: Large-scale artificial intelligence using radiomics, deep learning, and physics-based generative modeling to improve clinical outcomes in nuclear medicine


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Aging;Brain Disorders;Cerebrovascular;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Stroke

ORG_CITY: ALBUQUERQUE

ORG_NAME: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR

ORG_STATE: NM

PHR: Project Narrative The Southwestern Stroke Alliance (SSA) Regional Coordinating Center (RCC) aims to maximize efficiencies and conduct high-quality, multi-site clinical trials to improve stroke prevention, treatment, and recovery. By recruiting underrepresented minority populations and establishing partnerships with healthcare providers and community organizations, the SSA-RCC has the potential to improve stroke care and outcomes for special populations, addressing health disparities and improving public health.

PI_NAMEs: GIROTRA, TARUN  (contact);TORBEY, MICHEL T

PROJECT_TERMS: Acceleration;Address;Basic Science;bench to bedside;Blood Vessels;Caring;Clinical;Clinical Research;clinical trial recruitment;Clinical Trials;Clinical Trials Network;Collaborations;Colorado;Communities;community collaboration;community organizations;Contracts;Data;Education and Outreach;Eligibility Determination;Emergency Medicine;experience;Faculty;Goals;health disparity;Health Personnel;Health system;human subject protection;improved;Infrastructure;Institutional Review Boards;Intervention;Leadership;Measures;member;Minority Groups;Modeling;Multi-Institutional Clinical Trial;National Institute of Neurological Disorders and Stroke;neuroimaging;Neurology;neurosurgery;neurovascular;New Mexico;Outcome;outreach;Participant;Patient Participation;patient population;patient retention;Patients;Pediatric Neurology;Population;pre-clinical;preference;Principal Investigator;Progress Review Group;Protocols documentation;Public Health;Recovery;recruit;Rehabilitation therapy;Research;Research Personnel;Research Support;Resources;Site;Special Population;Specialist;Stroke;stroke clinical trials;stroke patient;Stroke prevention;stroke rehabilitation;Texas;Therapeutic;Training;Training Activity;Translations;Underrepresented Minority;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: The Southwestern Stroke Alliance Regional Coordinating Center


ADMINISTERING_IC: AR

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Physical Injury - Accidents and Adverse Effects

ORG_DEPT: BIOMEDICAL ENGINEERING

PHR: Project Narrative This proposal will combine tissue clearing, two photon microscopy, and multiview imaging to develop new and quantitative tools for investigating animal models of musculoskeletal injuries. These tools will then be applied to 3D spatially map inflammatory cellular and molecular signaling in tendon injury models, leading to a better understanding of the pathology, which could lead to new therapies.

PI_NAMEs: AWAD, HANI A;GIACOMELLI, MICHAEL GENE (contact)

PROGRAM_OFFICER_NAME: PINTUCCI, GIUSEPPE

PROJECT_TERMS: 3-Dimensional;Acceleration;adaptive immunity;Adhesions;animal imaging;Animal Model;Animals;Articular Range of Motion;Biologic Development;Biological Response Modifier Therapy;Biology;Blood Vessels;Cell Aging;Cell Density;Cell Physiology;Cell Proliferation;Cells;cellular imaging;Cellular Morphology;cellular targeting;Chronic;Cicatrix;Collagen Fibril;Color;Complex;cost;Custom;Data;Detection;Digit structure;Disease;Dissociation;Electronics;Etiology;Event;Extracellular Matrix;Fingers;Flexor;Flow Cytometry;Fluorescence;FRAP1 gene;functional outcomes;Generations;Hand;healing;Histology;Histopathology;Image;imaging platform;Immune;Immunofluorescence Immunologic;Immunophenotyping;Impairment;In Situ;Inflammatory;Injury;insight;Lateral;Light;Maps;Medicine;Microscope;microscopic imaging;Microscopy;Modeling;Molecular;molecular imaging;Molecular Target;Morphologic artifacts;mosaic;Motion;mouse model;mTOR Inhibitor;Mus;Musculoskeletal;musculoskeletal injury;Myofibroblast;Natural Immunity;Neurosciences Research;novel;novel strategies;novel therapeutics;Operative Surgical Procedures;Optics;Pathology;Physiological;Positioning Attribute;Postoperative Period;preclinical study;prevent;Process;Productivity;Proteins;Proteomics;Protocols documentation;reconstruction;Reporter;Reporter Genes;Research;Resolution;response to injury;Role;Sampling;second harmonic;second harmonic generation imaging;Signal Transduction;single cell analysis;Slide;spatial relationship;spatiotemporal;Specimen;Techniques;Technology;Tendon Injuries;Tendon structure;Testing;Three-dimensional analysis;Time;Tissue imaging;Tissues;tomography;tool;transcriptomics;Transgenic Mice;Transgenic Organisms;two photon microscopy;vascular inflammation;Work

PROJECT_TITLE: High throughput isotropic resolution fluorescence and second Harmonic imaging to characterize tendon injury

STUDY_SECTION: ISD

STUDY_SECTION_NAME: Instrumentation and Systems Development Study Section[ISD]


ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: PUBLIC HEALTH RELEVANCE Stroke remains the 5th leading cause of death in the United States (US) and a leading cause of adult disability. In the past decade, there have been tremendous strides in discovery of beneficial approaches to treat and prevent stroke, aided in part by conduct of large-scale clinical trials in StrokeNet. Leveraging our prior contributions to trial enrollment, proposal development, and trainee education, our renewal application as a regional coordinating center (RCC) in StrokeNet seeks to provide continued access to a diverse stroke patient population, consolidated multidisciplinary and multi-institutional expertise and leadership for StrokeNet trials, and ensure mentoring for trainees and junior faculty seeking academic careers in stroke. These efforts will identify new stroke treatments that reduce death and disability from stroke.

PI_NAMEs: PRABHAKARAN, SHYAM  (contact)

PROJECT_TERMS: Academic Medical Centers;Acute;acute stroke;Adult;aging population;Agreement;Ally;Area;Award;base;Biological Markers;Blood Vessels;Brain hemorrhage;career;Career Mobility;Caring;Cause of Death;Cessation of life;Chicago;Child;Clinical;Clinical and Translational Science Awards;clinical biomarkers;Clinical Trials;Clinical Trials Network;Collaborations;Community Outreach;cooking;cost;County;Data Coordinating Center;Development;Diagnostic;disability;Education;effective therapy;Elderly;Emergency Care;Emergency Medicine;Enrollment;Ensure;Environment;Ethnic Population;experience;Faculty;Fellowship;Fostering;Funding;Future;future implementation;Geography;Growth and Development function;high risk;Hospitals;Illinois;improved;Individual;Industry;Infrastructure;innovation;Institution;Institutional Review Boards;International;Intervention;Lead;Leadership;Medical center;medical schools;Medicine;Mentors;Mentorship;metropolitan;multi-ethnic;multidisciplinary;National Institute of Neurological Disorders and Stroke;neurological rehabilitation;Neurology;neuroprotection;neurosurgery;novel;patient population;Patient Recruitments;Patients;Pediatric Hospitals;Pediatric Neurology;Persons;phase III trial;Population Heterogeneity;Prevention;Prevention trial;Procedures;Process;Program Development;programs;public health relevance;Qualifying;Recording of previous events;Recovery;recruit;Rehabilitation therapy;Research;Research Personnel;Resources;response;Role;Sample Size;Site;skills;Societies;Standardization;statistics;Stroke;stroke patient;Stroke prevention;stroke rehabilitation;stroke therapy;stroke trials;System;telerehabilitation;Training Programs;translational medicine;trial enrollment;United States;United States Department of Veterans Affairs;United States National Institutes of Health;Universities;validation studies;Vulnerable Populations;Wisconsin;Work

PROJECT_TITLE: Chicago Stroke Trials Consortium


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Clinical Research;Drug Abuse (NIDA only);Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Neurosciences;Social Determinants of Health;Substance Misuse

ORG_CITY: GAINESVILLE

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Project Narrative Social behavior deficits are key features of many neuropsychiatric disorders, yet little is known about how the brain controls normal social behaviors. We propose to create a new artificial intelligence framework for social behavioral quantification that integrates diverse sources of behavior data to quantify spatiotemporal signatures or “motifs” of social behaviors. The easy-to-use toolkit which we call the Social Motif generator (So-Mo) will enable future studies to probe neural circuits during complex mouse behaviors at unprecedented resolution.

PI_NAMEs: PADILLA COREANO, NANCY  (contact);SAXENA, SHREYA ;WESSON, DANIEL W

PROGRAM_OFFICER_NAME: MOORE, HOLLY MARIE

PROJECT_TERMS: Accelerometer;Affective;Animals;Artificial Intelligence;artificial intelligence method;autoencoder;base;Behavior;Behavioral;Biological Rhythm;Black Box;Brain;brain control;BRAIN initiative;Breathing;Categories;Classification;cloud based;Code;Complex;computational neuroscience;Computer Vision Systems;Data;dimension reduction;Dimensions;Drops;Frequencies;Future;Goals;Hand;Head;Heart Rate;high dimensionality;improved;Individual;Infrastructure;insight;Knowledge;Label;Machine Learning;Manuals;Measurement;Measures;Methods;Modeling;Movement;Mus;neural circuit;neuromechanism;neuropsychiatric disorder;Neurosciences;novel;Outcome;Output;Pattern;Pharmacology;Physiological;Positioning Attribute;Recurrence;Research;resilience;Resolution;Role;sensory neuroscience;social;Social Behavior;Social Environment;Social Interaction;Social isolation;social movement;Source;spatiotemporal;Structure;Techniques;Time;tool

PROJECT_TITLE: Harnessing biological rhythms for a resilient social motif generator

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 SXC-N (O1)]


NIH_SPENDING_CATS: Bioengineering;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: ANN ARBOR

ORG_DEPT: ORTHOPEDICS

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT SUMMARY Our objective is to prevent degeneration of the tendon and enthesis following injury by leveraging the physiological processes associated with hypoxic cell survival and extracellular matrix production that are critical for tendon and enthesis development. In this project, we will determine the mechanisms of HIF1-alpha and hypoxia-dependent cell behavior of tendon and enthesis progenitor cells and their potential to modify extracellular matrix deposition using innovated and parallel approaches of in vivo murine models (for investigating cell autonomous and non-autonomous responses to hypoxia and HIF during development and healing) and in vitro synthetic biomaterials (for visualization of nascent protein deposition). The completion of this study will establish the role of Hif1a and hypoxia in maintaining, establishing, and protecting tendon and enthesis progenitors during development and healing.

PI_NAMEs: KILLIAN, MEGAN L. (contact)

PROJECT_TERMS: 3-Dimensional;achilles tendon;Adult;Agonist;Biocompatible Materials;Biomechanics;Biopsy;Blood Vessels;bone;cell behavior;Cell Death;Cell Differentiation process;Cell Hypoxia;Cell Lineage;Cell Physiology;Cell Survival;Cells;Chronic;Cicatrix;clinical care;Collagen;Collagen Type III;common treatment;Connective Tissue;Data;Deposition;Development;Distal;Drug Targeting;efficacy testing;Endoplasmic Reticulum;Exhibits;Extracellular Matrix;Fibrocartilages;Fibrosis;gain of function;Genetic Transcription;Goals;Growth;healing;HIF1A gene;Hydrogels;Hypoxia;Hypoxia Inducible Factor;hypoxia inducible factor 1;Impairment;improved;In Vitro;in vivo;Incidence;inducible Cre;Injury;innovation;Label;Laceration;loss of function;Maintenance;mechanical properties;Mechanics;mechanotransduction;Mediating;mimetics;Modeling;mouse model;Mus;musculoskeletal injury;Natural regeneration;novel;Outcome;overexpression;Pathologic;Patients;Perinatal;Persons;Pharmaceutical Preparations;pharmacologic;Physiological;Physiological Processes;postnatal;pre-clinical;Predisposition;prevent;Prevention;Process;Production;progenitor;Property;Proteins;regenerative;regenerative healing;Regulation;repaired;Reporter;response;response to injury;Risk;Role;Rupture;Sports;stem cell survival;stem cells;Tendinopathy;Tendon Injuries;tendon rupture;Tendon structure;Testing;Therapeutic;three dimensional cell culture;Time;tissue injury;Tissues;tool;transcriptome sequencing;Treatment Efficacy;Vascularization;Visualization;Work;wound healing

PROJECT_TITLE: Regulation of Tendon Enthesis Development and Healing via HIF1

STUDY_SECTION: SBSR

STUDY_SECTION_NAME: Skeletal Biology Structure and Regeneration Study Section[SBSR]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Biotechnology;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Transplantation

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF HOUSTON

PHR: Project Narrative Skeletal muscle stem cells and endothelial cells are key cell compartments responsible for proper muscle regeneration, vascularization and plasticity during physiologic or pathologic conditions such as exercise and growth or disorders such as dystrophies or injuries. Here we propose to study the interaction between these two cell types derived from human induced pluripotent stem cells, which are one of the top stem cell sources for cell therapy in case of skeletal muscle disorders. These studies allow identification of the involved molecular mechanisms of the cross-talks between skeletal muscle stem cells and endothelial cells, as well as their combined therapeutic efficiency in mouse models for muscular dystrophy or muscle injury.

PI_NAMEs: DARABI, RADBOD  (contact)

PROGRAM_OFFICER_NAME: LINDHURST, MARJORIE JEAN

PROJECT_TERMS: Anastomosis - action;angiogenesis;Biological Assay;Biological Models;Bioluminescence;Blood capillaries;candidate identification;Cell Communication;Cell Compartmentation;Cell Line;Cell Physiology;Cell Proliferation;Cell Survival;Cell Therapy;cell type;Cells;Circulation;Coculture Techniques;Coupled;cytokine;Data;density;deprivation;Derivation procedure;Development;differential expression;Direct Lytic Factors;Disease;Endothelial Cells;endothelial stem cell;Endothelium;Engraftment;Evaluation;Exercise;experimental study;FGF2 gene;Future;Gene Expression;Generations;Genes;Graft Survival;Growth;Growth Factor;Histologic;human induced pluripotent stem cells;Immune;improved;In Vitro;in vitro activity;in vitro Assay;in vitro Model;in vivo;in vivo engraftment;induced pluripotent stem cell;Injury;knock-down;Ligands;Location;Methods;migration;Migration Assay;Modeling;Molecular;mouse model;Muscle;muscle progenitor cell;muscle regeneration;muscular dystrophy mouse model;Myopathy;Natural regeneration;Nutrient;Outcome;Outcome Study;overexpression;Oxygen;paracrine;Pathologic;Pathway interactions;Physiological;Play;pluripotency;progenitor;Proliferating;Property;Proteins;Proteomics;receptor;Regenerative Medicine;Regulation;Research;Role;Serum;Signal Transduction;skeletal;Skeletal Muscle;Source;Stains;stem cell engraftment;stem cell function;stem cell model;stem cell niche;stem cell survival;stem cell therapy;Stem cell transplant;stem cells;Study models;Supplementation;Supporting Cell;System;Testing;Therapeutic;Time;Tissues;transcriptome sequencing;Transplantation;Vascular Endothelial Growth Factors;Vascularization;Vasculogenic;Western Blotting

PROJECT_TITLE: Study the mechanisms of interaction between hiPSC-derived endothelial (ECs) and skeletal myogenic progenitor cells (MPCs) in vitro and in vivo

STUDY_SECTION: SMEP

STUDY_SECTION_NAME: Skeletal Muscle and Exercise Physiology Study Section[SMEP]


NIH_SPENDING_CATS: Cancer;Clinical Research;Digestive Diseases;Liver Cancer;Liver Disease;Rare Diseases

ORG_CITY: LOS ANGELES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE Assessment of treatment response for hepatocellular carcinoma (HCC) is often difficult and inaccurate due to treatment-related non-specific changes on imaging tests. Recently, our team has successfully developed an HCC EV Digital Scoring Assay to detect early-stage HCC and measure the tumor burden. This study aims to conduct a revision application of HCC EV Digital Scoring Assay for evaluation of HCC treatment response, which may provide an accurate assessment and prevent frequent imaging tests.

PI_NAMEs: TSENG, HSIAN-RONG  (contact);ZHU, YAZHEN

PROGRAM_OFFICER_NAME: OSSANDON, MIGUEL

PROJECT_TERMS: Ablation;Aftercare;Area;assay development;Biological Assay;Biological Markers;Biometry;Cancer Etiology;case control;Cessation of life;Chemoembolization;Circulation;Clinical;cohort;Complement;Complex;digital;Early Diagnosis;Enrollment;Evaluation;extracellular vesicles;Frequencies;Funding;Future;Hepatic;Histologic;Image;Image Analysis;in-vitro diagnostics;Joints;liquid biopsy;Liver Cirrhosis;Logistic Regressions;Measures;Medical center;Messenger RNA;Microfluidics;Modality;Modeling;molecular pathology;Motivation;Names;nanomaterials;nanotechnology platform;neoplastic cell;Normal Cell;novel;Oncology;particle;Patients;Performance;Phase;Phospholipids;Plasma;preservation;prevent;Primary carcinoma of the liver cells;Process;radiological imaging;Radiology Specialty;Research;Reverse Transcription;ROC Curve;Sampling;Serum;Signal Transduction;Source;Testing;Training;Translations;treatment response;tumor;Tumor Burden;Tumor-Derived;United States National Institutes of Health;Validation;α-Fetoproteins

PROJECT_TITLE: HCC EV Digital Scoring Assay for assessing treatment response in HCC patients

STUDY_SECTION: CONC

STUDY_SECTION_NAME: Clinical Oncology Study Section[CONC]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Lung;Mental Health;Neurosciences;Precision Medicine;Sleep Research

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: LAY NARRATIVE  Obstructive sleep apnea is a common disorder and there is evidence that there are differences between patients with this disorder that are not explained by traditional measures of disease severity. Clinical subtypes based on patient-reported symptoms have been identified and validated. This project uses existing data to determine how objective measures of sleepiness, sleep duration, and sleep quality differ among these subtypes, as well as how subtypes based on subjective and/or objective data differ in cognition.

PI_NAMEs: PACK, ALLAN I (contact)

PROGRAM_OFFICER_NAME: YE, JANE

PROJECT_TERMS: actigraphy;Address;adverse outcome;Advocate;Anxiety;Attention;Back;Canada;Cardiac health;Cardiovascular Diseases;cardiovascular risk factor;Cardiovascular system;Characteristics;Chronic;circadian;Clinical;clinical subtypes;clinically relevant;Cluster Analysis;Cognition;Cognitive deficits;cognitive function;cohort;Communities;Complex;computerized;Data;design;Development;Diabetes Mellitus;Diagnosis;Disease;Drowsiness;Episodic memory;Evaluation;Event;Excessive Daytime Sleepiness;Exclusion;executive function;experience;Face;flexibility;follow-up;Future;Genomics;Health;Heterogeneity;High Prevalence;Iceland;Impaired cognition;Individual;insight;Knowledge;Learning;Letters;Link;Literature;Measurement;Measures;Memory;Mental Depression;mortality;Nerve Degeneration;Neurocognitive;Neurocognitive Deficit;Neuropsychology;Obstructive Sleep Apnea;Odds Ratio;Outcome;Participant;Patient Recruitments;Patient Self-Report;patient subsets;Patient-Focused Outcomes;Patients;Pennsylvania;Performance;personalized approach;personalized medicine;Phenotype;phenotypic data;Play;Polysomnography;poor sleep;population based;Psyche structure;Public Health;Questionnaires;Reporting;Reproducibility;Research;Risk;Role;Sampling;Severities;Severity of illness;Short-Term Memory;Sleep;Sleep Apnea Syndromes;sleep behavior;Sleep Deprivation;Sleep disturbances;sleep quality;Sleeplessness;Subgroup;Symptoms;Technology;Testing;United States;Universities;unsupervised clustering;verbal;vigilance;Work

PROJECT_TITLE: Objective measures of sleepiness and cognitive function in different symptom subtypes of OSA

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: OKLAHOMA CITY

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PHR: Project Narrative. Cancer affects all populations, but some communities shoulder a heavier risk than others. In particular, persons from tribal, rural and urban inner-city communities face daunting challenges in accessing cancer screening and diagnostic follow-up services. The SCC Oklahoma TRUST ACCESS Hub will bring recent advances in cancer screening to high-risk tribal, rural and urban inner-city populations by increasing access to cutting-edge cancer screening trials.

PI_NAMEs: DOESCHER, MARK P (contact);MOORE, KATHLEEN N.

PROJECT_TERMS: acceptability and feasibility;Address;Affect;African American;Age;aged;Alaska Native;American Indian community;American Indian Population;American Indians;Biological;Black race;Cancer Center;cancer health disparity;cancer prevention;Caring;Catchment Area;Cities;Clinic;Clinical;Clinical Cancer Center;Clinical Trials;Collaborations;Communities;community engagement;Community Healthcare;Community Outreach;Data;Data Collection;data sharing;Death Rate;design;Development;Diagnostic;Disadvantaged;distrust;Educational process of instructing;English Language;Enrollment;Ensure;Ethics;Ethnic Origin;experience;Face;Federally Qualified Health Center;follow-up;Foundations;Future;geographic barrier;Geography;Goals;Health;Health care facility;Health Insurance;Healthcare;Healthcare Systems;high risk;Home;Incidence;Infrastructure;inner city;Institution;Insurance Coverage;interest;Intervention;Leadership;Low income;low socioeconomic status;Malignant Neoplasms;Methods;Oklahoma;Organizational Affiliation;Participant;patient-level barriers;Patients;Persons;Population;Positioning Attribute;primary care clinic;Process;programs;Provider;racial minority;Research;Research Personnel;Rights;Risk;Risk Factors;Rural;rural area;rural counties;Rural Population;screening;Screening for cancer;screening services;Services;Shapes;Shoulder;Site;Spanish;Structure;System;Testing;treatment trial;tribal community;Tribal group;tribal healthcare;Tribes;Trust;Underinsured;Underrepresented Populations;United States;United States Indian Health Service;Universities;uptake;urban area;urban Native American;Urban Population

PROJECT_TITLE: Oklahoma Tribal, Rural, Urban Cancer Screening Trial ACCESS Hub


NIH_SPENDING_CATS: Brain Disorders;Cerebrovascular;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Pediatric;Stroke

ORG_CITY: WASHINGTON

ORG_DEPT: PHYSICAL MEDICINE & REHAB

ORG_NAME: GEORGETOWN UNIVERSITY

ORG_STATE: DC

PHR: Project Narrative The Stroke Central Atlantic Network for Research encompasses the Mid-Atlantic region. As a Regional Coordinating Center (RCC), it will continue recruiting people with stroke for trials ranging from prevention to acute intervention to rehabilitation. The unusual features of this RCC are its capture of nearly all stroke patients in DC and much of the Mid-Atlantic, its ability to recruit underserved individuals from both urban and rural settings, and its research strengths in multimodal MRI, genetics, Neurorehabilitation, and disparities.

PI_NAMEs: HSIA, AMIE ;TURKELTAUB, PETER ETHAN (contact);WORRALL, BRADFORD B

PROJECT_TERMS: Acute;acute stroke;Adult;African American;Area;Baltimore;Biological Markers;Black race;career;career development;Child;Childhood;Childhood stroke;Clinical;Clinical Research;Development;Disparity;Eligibility Determination;Enrollment;experience;Funding;Genetic;Health;Health Disparities Research;Healthcare Systems;Historically Black Colleges and Universities;Hospitals;Image;improved;innovation;Intervention;Leadership;Link;Magnetic Resonance Imaging;Maryland;Medical center;Mentors;Mentorship;Mid-Atlantic Region;multidisciplinary;multimodality;National Institute of Neurological Disorders and Stroke;neurological rehabilitation;news;Participant;participant retention;patient population;Patient Recruitments;Patients;Pediatrics;Persons;Play;Prevention;Prevention trial;Productivity;Program Development;programs;recruit;Registries;Rehabilitation therapy;Reporting;Research;research and development;Research Personnel;Resources;Role;rural setting;Saturn;Scientist;screening;Secondary Prevention;Site;Stroke;Stroke Belt;stroke incidence;stroke patient;stroke rehabilitation;stroke trials;System;Training;treatment trial;Underserved Population;Universities;urban setting;Virginia;Washington

PROJECT_TITLE: Stroke Central Atlantic Network for Research (SCANR)


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Disability Research;Emergency Care;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Physical Rehabilitation;Prevention;Racial and Ethnic Minority Health Research;Rehabilitation;Stroke

PHR: Project Narrative Stroke is the leading cause of combined death and severe disability in the United States. It is imperative that new treatments for stroke prevention, acute therapy, and recovery be efficiently developed. This application is to renew a large-scale regional clinical trial network to accelerate testing and validation of promising new stroke preventive, acute, and reparative therapies.

PI_NAMEs: BULIC, SEBINA ;SAVER, JEFFREY L (contact)

PROJECT_TERMS: Academic Medical Centers;Acceleration;Achievement;Acute;acute stroke;Address;Adherence;Adult;African American;African American population;Aging;American;arm;Award;biomarker validation;California;career;career development;Cause of Death;cerebrovascular;Cerebrovascular Disorders;Cessation of life;Child;Clinical Research;Clinical Trials Network;Collaborations;Communities;County;decision-making capacity;Dedications;disability;Disease;educational atmosphere;Emergency Department Physician;Emergency Medicine;Ensure;experience;Faculty;follow-up;Funding;Geographic Locations;Goals;Grant;Hispanic Americans;Hospitals;Impairment;Individual;Infrastructure;Inpatients;Intervention;Investments;Leadership;Los Angeles;Medical;Medical center;Medical Students;Mentors;Mentorship;mid-career faculty;Minority Groups;Multi-Institutional Clinical Trial;National Institute of Neurological Disorders and Stroke;Neurologist;Neurology;Neurosurgeon;neurosurgery;neurovascular;New Mexico;novel;Nurses;Oranges;Outcome Measure;outreach;Paramedical Personnel;Patient Dropouts;Patient Noncompliance;Patients;Pediatric Hospitals;Performance;performance site;Phase;Physical Medicine;Physical Rehabilitation;Physicians;Population;post stroke;Premedical Students;Prevention;Prevention trial;Preventive;programs;randomized, clinical trials;Recovery;recruit;Rehabilitation Centers;Rehabilitation therapy;rehabilitative care;Research;Research Personnel;research study;Resources;safety net;Self Perception;Stroke;Stroke prevention;stroke recovery;stroke rehabilitation;stroke therapy;stroke trials;success;System;Testing;Time;Training;Translational Research;treatment trial;Underserved Population;United States;United States National Institutes of Health;Universities;Validation;validation studies;Woman

PROJECT_TITLE: Los Angeles - Southern California (LASC) NIH StrokeNet Regional Coordinating Center


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Clinical Research;Data Science;Genetics;Human Genome;Lung;Lung Cancer;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: NARRATIVE The proteome is the entirety of all proteins in a cell, tissue, or body fluid. It constitutes the functional and structural backbone of biological systems and is the closest molecular link to the system’s phenotype. However, unbiased proteome mapping (proteomics) is still underused in our attempts to understand diseases, and it is largely untapped in clinical studies. A major reason for this is a lack of sample throughput when compared to genomics technologies. We propose to address this issue by building on the enormous recent progress in artificial intelligence (AI) to develop a novel mass spectrometry-based approach for analyzing proteomes. This allows for increasing the sample throughput by up to 10-fold over existing methods. We will evaluate the method by mapping blood plasma biomarkers for lung cancer detection in 500 clinical plasma samples.

PI_NAMEs: HAAS, WILHELM  (contact);SEQUIST, LECIA V.

PROJECT_TERMS: Address;Artificial Intelligence;artificial intelligence method;Atlas of Cancer Mortality in the United States;Bar Codes;Behavior;Biological Assay;Biological Markers;biological systems;biomarker discovery;biomarker identification;Blood Proteins;Body Fluids;Cancer cell line;Cancer Detection;cancer diagnosis;Cancer Diagnostics;cancer genome;Cancer Patient;cancer proteomics;Cell division;Cells;Chromatography;Clinical;clinical application;Clinical Research;Communities;Complex;cost;Cost Analysis;Data;data acquisition;Data Analyses;Detection;diagnostic value;Disease;DNA sequencing;Early Diagnosis;early screening;Evaluation;Excision;Expert Systems;Genome;Genomics;Goals;Human;improved;Ions;Laboratories;Link;Malignant neoplasm of lung;Malignant Neoplasms;Maps;mass spectrometer;Mass Spectrum Analysis;Methods;Modeling;Molecular;Monitor;neural network;Neural Network Simulation;Non-Small-Cell Lung Carcinoma;novel;novel strategies;Operative Surgical Procedures;Pathologic;Patients;Peptides;Phenotype;Plasma;Plasma Proteins;Post-Translational Protein Processing;Preparation;Process;Property;protein biomarkers;protein degradation;protein protein interaction;Proteins;Proteome;Proteomics;Reagent;Regulation;Resolution;Sampling;Sampling Studies;screening;Screening for cancer;Speed;System;Technology;Time;Tissue Sample;Tissues;tool;Training;Translating;tumor;Tumor Markers;Tumor Tissue;uncontrolled cell growth;Vertebral column

PROJECT_TITLE: A Real-Time AI-Driven High-Throughput Proteomics Data Acquisition Method for Clinical Applications

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 TCRB-D (O1)]


NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Emergency Care;Heart Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pediatric

ORG_CITY: VILLANOVA

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: VILLANOVA UNIVERSITY

PHR: Project narrative Cardiopulmonary Resuscitation (CPR) is a commonly performed procedure (more than 15,000 children in US alone) to resuscitate a stopped heart and the conventional procedure is not very effective especially for pediatric patients since less than 50% survive to discharge. The proposed research will use already collected data and develop a computational model to identify patients who are unlikely to survive with conventional CPR and can beneﬁt from a special procedure called ECPR that has been known to improve survival under certain circum- stances. The proposed research will provide a systematic and mathematically sound procedure to pick ECPR candidates and is expected to result in substantial improvement of survival rates for pediatric populations.

PI_NAMEs: NATARAJ, CHANDRASEKHAR  (contact)

PROGRAM_OFFICER_NAME: PEMBERTON, VICTORIA

PROJECT_TERMS: Achievement;Adopted;Adoption;Adult;Affect;Algorithms;Area;Biochemical;Blood flow;Blood Pressure;candidate identification;Cardiac Output;Cardiopulmonary Resuscitation;Characteristics;Child;Childhood;Circulation;Clinical;Computational algorithm;Computer Models;Confidence Intervals;Critical Care;Critical Illness;Data;Data Set;Decision Support Systems;Development;Drops;Early identification;Engineering;evidence base;experience;Extracorporeal Membrane Oxygenation;Failure;Foundations;Future;Glean;Goals;Heart;Heart Arrest;Hospitalized Child;Hospitals;improved;improved outcome;Infrastructure;innovation;insight;Intervention;Lead;Life;Location;Machine Learning;machine learning algorithm;machine learning model;Mathematics;Medical;Methods;Modeling;Morbidity - disease rate;National Heart, Lung, and Blood Institute;Neurologic;Neurological outcome;novel;Organ;Outcome;Patient-Focused Outcomes;Patients;pediatric patients;Perfusion;Physiological;Population;Procedures;Provider;Receiver Operating Characteristics;Research;Resuscitation;Sampling;Shock;signal processing;Signal Transduction;Solid;sound;survival outcome;survival prediction;Survival Rate;Therapeutic;Work

PROJECT_TITLE: Evaluating and improving the efficacy of Extracorporeal Cardiopulmonary Resuscitation (ECPR) in pediatric patients using interactive Machine Learning

STUDY_SECTION: CDMA

STUDY_SECTION_NAME: Clinical Data Management and Analysis Study Section[CDMA]


ORG_CITY: Decatur

ORG_NAME: VETERANS HEALTH ADMINISTRATION

PHR: Glaucoma is the leading cause of irreversible blindness worldwide, and Veterans have twice the prevalence of glaucoma compared to the general US population. Overall, women represent 59% of the affected population; however, the number of women Veterans have doubled over the last ten years. Studies have recently demonstrated that early menopause, which corresponds with a decrease in circulating estrogen, mutations in estrogen receptors, and polymorphisms along the estrogen metabolic pathway are linked to developing glaucoma. Therefore, we must better understand whether menopause directly affects developing glaucoma in women. In this proposal, our goal is to perform a retrospective analysis using the national VA database (VINCI) to assess if menopause is related to the onset of glaucoma in a Veteran population. In addition, we will determine if hormone replacement therapy (HRT) delays the onset of glaucoma in postmenopausal women. This study will identify how menopause is associated with glaucoma and the potential of HRT as a novel treatment.

PI_NAMEs: FEOLA, ANDREW J (contact)

PROJECT_TERMS: Address;Affect;Age;age effect;Aging;Animal Model;Attention;Blindness;care systems;cell injury;Clinical Data;Clinical Research;clinically relevant;Combined Modality Therapy;Communication;Data;data warehouse;Databases;Development;Disease;Elderly;Estrogen Receptors;Estrogens;Event;Exhibits;experience;Experimental Models;Eye;Female;Frequencies;Future;General Population;Genetic Polymorphism;Glaucoma;Goals;Health;High Prevalence;Hormone replacement therapy;Hormone use;Incidence;Inflammation;Informatics;Infrastructure;Ischemia;Knowledge;Laboratories;Life;Life Expectancy;Link;longitudinal care;male;medical examination;Medical Records;Menopausal Status;Menopause;Metabolic Pathway;military veteran;modifiable risk;Monitor;Mutation;neuroprotection;novel;Open-Angle Glaucoma;Ophthalmologist;Ophthalmology;Patients;Persons;Physiologic Intraocular Pressure;Population;Postmenopause;Premature Menopause;Prevalence;prevent;Progesterone;Prospective Studies;Recording of previous events;Records;Research;Research Personnel;Resources;Retinal Ganglion Cells;Retrospective Studies;Risk;Risk Assessment;Risk Factors;secondary analysis;sex;surgical menopause;Technology;Veterans;Vision;Woman;women patients;women versus men;Women's Health;Women's prevalence;Work

PROJECT_TITLE: The Relationship of Menopause to the Onset of Glaucoma in Veterans

STUDY_SECTION: RRDS

STUDY_SECTION_NAME: Rehabilitation Research and Development SPiRE Program[RRDS]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE Sensitive, inexpensive, and rapid genetic sequencing is changing how people interact with and study everything involving living organisms (e.g., medicine, public health, agriculture, biotechnology, natural resources, etc.) by making enormous quantities of sequence data easily available. We are developing and using methods that exploit voluminous protein sequence data to help design biochemical experiments that yield results broadly applicable beyond the specific example tested. Our work may allow prediction of the information processing capabilities of microorganisms and may influence design of therapeutic agents to disable regulatory systems that control virulence, viability, or drug susceptibility of microbial pathogens.

PI_NAMEs: BOURRET, ROBERT B. (contact)

PROGRAM_OFFICER_NAME: BARSKI, OLEG

PROJECT_TERMS: Agriculture;Amino Acid Sequence;Amino Acids;antibiotic design;Antibiotics;Architecture;Behavior;Biochemical;Biochemistry;Bioinformatics;Biological Process;Biophysics;Biotechnology;Cells;Characteristics;Cluster Analysis;Communicable Diseases;Complex;Data;defined contribution;design;Development;Devices;dimension reduction;Dimerization;Disease;Enzyme Kinetics;Eukaryota;Exhibits;Experimental Designs;experimental study;fitness;Foundations;Genetic;Genomics;Goals;High-Throughput Nucleotide Sequencing;Histidine;human disease;information processing;innovation;insight;interest;Investigation;Kinetics;Life;loss of function;Measures;Medicine;Methods;microbial;microorganism;Molecular;Molecular Biology;Natural Resources;Nature;Organism;Output;pathogen;pathogenic microbe;Persons;Pharmaceutical Preparations;Phenotype;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphotransferases;Physiological;Physiology;Plants;Positioning Attribute;Predisposition;Productivity;Prokaryotic Cells;Property;Protein Dephosphorylation;Protein Family;protein function;Proteins;Public Health;Reaction;Regulation;Research;response;sensor;Sequence Analysis;Signal Transduction;Signaling Protein;Stimulus;structural biology;synthetic biology;System;Systems Biology;Tertiary Protein Structure;Testing;Therapeutic Agents;Time;usability;Virulence;Water;Work

PROJECT_TITLE: Molecular Mechanisms of Signal Transduction by Two-Component Regulatory Systems

STUDY_SECTION: PCMB

STUDY_SECTION_NAME: Prokaryotic Cell and Molecular Biology Study Section[PCMB]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease;Patient Safety

ORG_CITY: KALAMAZOO

ORG_NAME: CROSSLINER INC

PHR: NARRATIVE Approximately 28% of guide extension catheters fail to achieve successful treatment in patients undergoing complex percutaneous coronary intervention due to inability to access, and deliver stents to calcified lesions in tortuous vessels. The objective of this proposal is to complete design verification and process development of a novel multi-functional guide extension catheter system that is expected to improve the safe, effective and efficient revascularization of coronary lesions in the growing number of patients undergoing complex PCI.

PI_NAMEs: FISCHELL, TIM ALEXANDER (contact);MIRIZZI, MICHAEL ;SALTIEL, FRANK S

PROGRAM_OFFICER_NAME: HALLER, JOHN WAYNE

PROJECT_TERMS: Address;Adoption;Affect;American;Anatomy;Animals;Arteries;Balloon Dilatation;calcification;Catheters;Cerebrovascular Disorders;Chronic;Clinical;commercialization;comparative;Complex;Complication;Coronary;Coronary Arteriosclerosis;Coronary artery;coronary lesion;Coronary Vessels;cost;Data;design;design verification;Development;Device Safety;Devices;Dilatation - action;Disease;Dissection;Distal;Elements;Evaluation;Failure;Financial Hardship;Flare;Foundations;Healthcare Systems;Human;improved;in vivo;innovation;innovative technologies;Intervention;Interview;Intubation;Lead;Lesion;Location;Marketing;Methods;mortality;National Heart, Lung, and Blood Institute;novel;Outcome;Pacemakers;patient population;patient safety;Patients;percutaneous coronary intervention;Perforation;Performance;Peripheral;Phase;Positioning Attribute;prevent;Probability;Procedures;Process;Production;Qualifying;Radial;Radiation;Radiation Dose Unit;restenosis;revascularization;Risk;Safety;Site;Specific qualifier value;standard of care;Stents;success;System;Technology;Testing;Therapeutic Embolization;Thrombus;Time;Tube;Tubular formation;United States National Institutes of Health;usability;Validation;Venous

PROJECT_TITLE: Catheter for Complex Percutaneous Coronary Intervention

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-F (O1)]


ADMINISTERING_IC: DE

ED_INST_TYPE: HOSPITALS

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Data Science;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Radiation Oncology;Rare Diseases;Sexually Transmitted Infections

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: PROJECT NARRATIVE Clinical decision support tools for oropharyngeal cancer (OPC) using diagnostic imaging and clinical data have the potential to improve metastatic cervical lymph node auto-segmentation and extracapsular nodal extension detection, which could subsequently guide actionable treatment planning for improved efficacy with minimal side effects. We propose novel probabilistic deep learning methods that can simultaneously detect, segment, and classify of metastatic lymph nodes using pretreatment multi-modality imaging and clinical data with patient- specific probabilistic estimation of segmentation and classification accuracy. These advancements would improve public health by enhancing the accuracy of the risk stratification of OPC patients for appropriate treatments, ultimately improving treatment outcomes and quality of life of OPC survivors.

PI_NAMEs: FULLER, CLIFTON DAVID;NASER, MOHAMED  (contact)

PROGRAM_OFFICER_NAME: OKI, NOFFISAT

PROJECT_TERMS: 3-Dimensional;Address;Adjuvant;Adjuvant Therapy;anatomic imaging;Area Under Curve;Artificial Intelligence;artificial intelligence method;automated segmentation;Biopsy;Black Box;Cancer Patient;Cancer Survivor;Cervical lymph node group;chemoradiation;Classification;Clinical;clinical application;Clinical Data;clinical decision support;clinical decision-making;clinical implementation;Combined Modality Therapy;contrast enhanced computed tomography;Data;Data Set;Decision Making;deep learning;deep learning model;Detection;Diagnostic Imaging;Dimensions;Disseminated Malignant Neoplasm;Evaluation;experience;External Beam Radiation Therapy;Extracapsular;Functional Imaging;Goals;Guidelines;Head and Neck Cancer;head and neck cancer patient;high dimensionality;Histopathology;HPV oropharyngeal cancer;Human;Image;Image Enhancement;imaging Segmentation;improved;improved outcome;Incidence;Interobserver Variability;large datasets;learning classifier;Long Term Survivorship;lymph nodes;Machine Learning;Magnetic Resonance Imaging;malignant oropharynx neoplasm;Manuals;Medical;Medical Imaging;Methods;Mixed Neoplasm;Modeling;Multimodal Imaging;multimodality;Nodal;Normal tissue morphology;novel;Operative Surgical Procedures;Oral;Outcome;Output;Pathologic;Patient risk;Patients;Performance;Play;Positron-Emission Tomography;Postoperative Period;predictive modeling;Procedures;Process;prognostic;Prognostic Factor;Public Health;Quality of life;Radiation therapy;radiological imaging;Radiology Specialty;Reporting;Reproducibility;Research;Resectable;Risk;Risk Assessment;Risk Estimate;Risk Factors;risk stratification;Robotics;ROC Curve;Role;Scanning;Selection for Treatments;Sensitivity and Specificity;Series;side effect;Site;standard of care;support tools;Survivors;Testing;Toxic effect;Training;Treatment outcome;treatment planning;tumor;Uncertainty;X-Ray Computed Tomography

PROJECT_TITLE: Probabilistic Deep Learning Cervical Lymph-Node Auto-Segmentation For Imaging-enhanced Evaluation of Extracapsular Extension Risk (PDL-CLASIFIER)

STUDY_SECTION_NAME: Special Emphasis Panel[ZDE1 YM (04)]