NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Coronaviruses;Emerging Infectious Diseases;Infectious Diseases;Lung;Microbiome

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Narrative The COVID-19 pandemic had a major impact in the health of the U.S. population and has destabilized health care systems worldwide due to the high mortality among critically ill patients. In this grant, we will take advantage of our existing biorepository of longitudinal lower airway and blood samples from critically ill COVID- 19 patients to explore novel ways of endotyping using scRNA sequencing and metabolome approaches to better understand factors that lead to poor clinical outcomes.

PI_NAMEs: SEGAL, LEOPOLDO NICOLAS (contact)

PROGRAM_OFFICER_NAME: ZHAO, XIAOLI

PROJECT_TERMS: 2019-nCoV;acute COVID-19;Antibody Response;Area;aspirate;bacteriome;biobank;Biological Response Modifiers;Blood;Blood specimen;Bronchoalveolar Lavage;Bronchoscopy;Caring;Cells;Circulation;Clinical;clinical heterogeneity;Communities;COVID-19;COVID-19 pandemic;COVID-19 patient;COVID-19 severity;Credentialing;Critical Care;Critical Illness;Disease;Ensure;Environment;Etiology;Event;Evolution;experience;Funding;Future;Grant;Health;Healthcare Systems;host-microbe interactions;Human;Immune;Immune response;Immunoglobulin G;Individual;Infrastructure;Investigation;Mediating;metabolome;metabolomics;microbial;Microbiology;Molecular;Molecular Profiling;mortality;mortality risk;multiple omics;Nature;New York;New York City;novel;novel marker;Outcome;pathogen;Pathway interactions;Patients;Peripheral Blood Mononuclear Cell;Phase;Physicians;Population;Process;prognostication;Protocols documentation;Publications;Publishing;Reporting;Research;Resources;respiratory microbiome;response;sample collection;Sampling;Sampling Studies;SARS-CoV-2 infection;Secure;septic patients;single-cell RNA sequencing;Source;Standardization;Testing;Time;Trachea;trait;transcriptome;transcriptomics;United States;Viral;Viremia;virome;Virus Replication

PROJECT_TITLE: BIOREPOSITORY OPTIMIZATION AND USE FOR ENDOTYPING CRITICALLY ILL SARS-COV-2 INFECTED PATIENTS

STUDY_SECTION: IRAP

STUDY_SECTION_NAME: Infectious Diseases, Reproductive Health, Asthma and Pulmonary Conditions Study Section[IRAP]


ADMINISTERING_IC: GM

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Brain Disorders;Down Syndrome;Intellectual and Developmental Disabilities (IDD)

ORG_CITY: Aurora

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: NARRATIVE The University of Colorado is home to one of the only academic centers fully devoted to Down syndrome (DS) research, the Linda Crnic Institute for Down Syndrome (Crnic Institute) and MOLB T32 Training program closely collaborates with Crnic Institute to advance biomedical research in DS. The main objective of this proposal is to work with Crnic Institute in training of high quality, passionate PhD scientists who have learned to think critically and independently and are dedicated in pursuing careers in studying DS.

PI_NAMEs: HESSELBERTH, JAY R;PREKERIS, RYTIS  (contact)

PROGRAM_OFFICER_NAME: JONES, LATAISIA CHERIE

PROJECT_TERMS: Molecular and Cellular Biology;pre-doctoral;Training Programs

PROJECT_TITLE: Predoctoral Training Program in Molecular and Cellular Biology


ADMINISTERING_IC: HL

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Chronic Obstructive Pulmonary Disease;Climate-Related Exposures and Conditions;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Health Effects of Household Energy Combustion;Health Effects of Indoor Air Pollution;Lung;Prevention;Social Determinants of Health;Tobacco;Tobacco Smoke and Health

ORG_CITY: BALTIMORE

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE COPD is a leading cause of death and morbidity worldwide and is attributable to the aggregate burden of toxic gases and particles that individuals inhale during their lifetime. Particulate matter (PM) and nitrogen dioxide (NO2) are common pollutants in indoor environments where adults with COPD spend >90% of their time. We propose a Phase III multi-center randomized sham-controlled trial to test the effectiveness of an air cleaner intervention targeting indoor pollutants (PM and NO2) on quality of life and exacerbation risk reduction among former smokers with COPD (n~770) across multiple clinical practice locations.

PI_NAMEs: HANSEL, NADIA N (contact)

PROGRAM_OFFICER_NAME: POSTOW, LISA

PROJECT_TERMS: Acute;Address;Adherence;Adult;Air;air cleaner;airway epithelium;airway inflammation;Baltimore;Biomass;Carbon;Caring;Cause of Death;Chronic;Chronic Obstructive Pulmonary Disease;cigarette smoke;Clinical;clinical efficacy;clinical practice;Collaborations;combustion product;Complex Mixtures;Controlled Clinical Trials;cost effective;cost effectiveness;Cost Effectiveness Analysis;Data;Data Coordinating Center;disabling disease;Dose;economic evaluation;Economics;effective intervention;effectiveness evaluation;effectiveness testing;EuroQOL;Evidence based intervention;Exposure to;former smoker;Gases;Geographic Locations;Guidelines;Health;health care service utilization;high risk;Home;improved;incremental cost;Individual;indoor air;Indoor environment;indoor pollutant;Inhalation;Intention;International;Intervention;Literature;Location;markov model;Measurable;Measures;Methods;Morbidity - disease rate;mortality;Nitrogen Dioxide;Nonpharmacologic Therapy;novel strategies;Outcome;Oxidative Stress;Participant;particle;Particulate;Particulate Matter;Patients;Pharmaceutical Preparations;Phase;Policies;pollutant;portability;Prevention;primary endpoint;primary outcome;Protocols documentation;Pulmonary Inflammation;Quality of life;Quality-Adjusted Life Years;Questionnaires;Randomized;Randomized, Controlled Trials;Recommendation;recruit;respiratory;respiratory morbidity;Respiratory Signs and Symptoms;response;Risk;Risk Reduction;secondary analysis;secondary outcome;Site;smoking cessation;Societies;Source;Symptoms;systemic inflammatory response;Third-Party Payer;Time;trend;trial design;Viral;Water

PROJECT_TITLE: 1/2 Multi-Center CLEAN AIR 2 Randomized Control Trial in COPD

STUDY_SECTION: CLTR

STUDY_SECTION_NAME: Clinical Trials Review Study Section[CLTR(MA)]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Aging;Arthritis;Chronic Pain;Genetics;Human Genome;Neurodegenerative;Neurosciences;Osteoarthritis;Pain Research;Peripheral Neuropathy

ORG_CITY: HOUSTON

ORG_DEPT: GENETICS

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: Project Narrative Post traumatic osteoarthritis (OA) can cause severe nociceptive and neuropathic pain that can negatively impact the quality of life. Targeted development of joint-pain–modifying therapeutics has been hampered by limited knowledge of the cellular and molecular pathways that mediate pain sensation in the joint, a knowledge gap the RE-JOIN consortium is working to fill in small animal models and patients with OA. Here, we propose to develop novel resources to enable preclinical and mechanistic studies related to joint pain in the horse, a reliable large animal model of OA.

PI_NAMEs: ARENKIEL, BENJAMIN R;LEE, BRENDAN  (contact);RAY, RUSSELL S;WYTHE, JOSHUA D.

PROGRAM_OFFICER_NAME: MANCINI, MARIE

PROJECT_TERMS: 3-Dimensional;Acceleration;Affect;Afferent Neurons;Age;Aging;American;Anatomy;Animal Model;Arthralgia;arthropathies;Cell Nucleus;cell type;Cells;Cervical spine;Chronic;chronic pain patient;Clinic;clinical care;Communities;Comparative Study;Country;Data;Degenerative polyarthritis;Development;Disease;Disease Progression;effective therapy;Equus caballus;Exercise;experience;experimental study;Family suidae;Female;fitness;Future;Gender;gene therapy;Genetic;Goals;Health system;healthcare burden;Helping to End Addiction Long-term;Histologic;Human;Image;Individual;Interleukin-1;Joints;Knee joint;Knowledge;Label;male;Maps;Mediating;Methods;Modeling;Molecular;Molecular Profiling;mouse model;multidisciplinary;multiple omics;Mus;nerve supply;neural;Neurons;new growth;new therapeutic target;Nociception;novel;Opioid;opioid epidemic;osteochondral tissue;Outcome;Pain;pain behavior;pain reduction;pain sensation;painful neuropathy;parent grant;Pathology;Pathway interactions;Patients;phase I trial;Phenotype;pre-clinical;preclinical study;Protein Isoforms;Public Health;Quality of life;Rattus;Regenerative Medicine;Research;Resources;Review Literature;Rodent;Safety;screening;Sensory;Signal Transduction;single nucleus RNA-sequencing;Societies;socioeconomics;Speed;Spinal Ganglia;Structure of intercarpal joint;Technology;Therapeutic;therapeutic candidate;therapeutic development;therapy development;thoracic vertebra bone structure;Tissues;tool;Tracer;transcriptome;transcriptome sequencing;transcriptomics;translational model;translational scientist;translational study;Traumatic Arthropathy;United States;Viral

PROJECT_TITLE: Neuronal anatomy, connectivity, and phenotypic innervation of the knee joint


NIH_SPENDING_CATS: Genetics

PHR: This Project Narrative was originally submitted with R01GM143774 and is included here unchanged to satisfy submission system requirements. Project Narrative The goal of this project is to understand the roles of post-abscission midbodies (MBs). We already have shown that these MBs are internalized by neighboring cells where they form a novel signaling organelles known as MBsomes. Importantly, it was suggested that the accumulation of intra-cellular MBsomes regulates cell proliferation and differentiation. Thus, completion of this project will identify and characterize the molecular machinery governing the internalization and formation of MBsomes, as well as will define signaling pathways that mediate MBsome function.

PI_NAMEs: PREKERIS, RYTIS  (contact);RAPOSO, GRACA GRACA

PROGRAM_OFFICER_NAME: MILLER, RITA K

PROJECT_TERMS: Administrative Supplement;Binding Proteins;cancer cell;Cell Differentiation process;Cell Proliferation;Cells;CENP-E protein;Complex;CRISPR screen;Cytokinesis;daughter cell;Excision;Extracellular Space;Goals;Grant;Maps;Mediating;Messenger RNA;Microtubules;Mitosis;Molecular;Mothers;novel;Organelles;Play;postmitotic;Proliferating;Proteins;Proteomics;Protocols documentation;recruit;Resolution;RNA-Binding Proteins;Role;Signal Pathway;Signal Transduction;stem cells;Stimulation of Cell Proliferation;Structure;System;Testing;Thinness;transcriptome sequencing;Translations;Untranslated Regions

PROJECT_TITLE: Administrative Supplement for R01GM143774 grant


ADMINISTERING_IC: CA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative The proposed project will begin to address the knowledge gap in research evidence use for vaccine preventable cancers among policymakers in Nigeria. Integrating methods from the fields of policy dissemination research and participatory methods, we will identify preferences and priorities for research evidence use and develop a data-driven dissemination strategies to increase uptake of research evidence by policymakers. Findings will address policy and dissemination science knowledge deficits for cancer control policies on vaccines for preventable cancers, in Nigeria, Africa’s most populous country.

PI_NAMEs: EZECHI, OLIVER CHUKWUJEKWU;IWELUNMOR, JULIET  (contact);TUCKER, JOSEPH DAVID

PROGRAM_OFFICER_NAME: CORREA-MENDEZ, MARGARITA

PROJECT_TERMS: Acceleration;Address;Adopted;Advocate;Africa;American;anti-cancer research;Behavior;Cancer Control;Cancer Control Research;cancer health disparity;Characteristics;Classification;Collaborations;Country;Data;Decision Making;design;dissemination research;dissemination science;dissemination strategy;Eligibility Determination;Ensure;Equity;Event;evidence base;Exercise;Exploration, Preparation, Implementation, and Sustainment;Goals;Hepatitis B Vaccines;Heterogeneity;Hour;Human Papilloma Virus Vaccine;implementation barriers;improved;Individual;innovation;insight;Institution;interest;Intervention;Interview;Knowledge;Link;Malignant neoplasm of cervix uteri;Malignant neoplasm of liver;Malignant Neoplasms;Maps;Medical Research;Methods;Nigeria;Nigerian;organizational climate;Outcome;Pattern;person centered;Police;Policies;Policy Maker;Policy Making;Population;preference;Process;Public Health;Quality of Care;Research;Research Design;Research Personnel;Research Priority;response;Subgroup;Surveys;tool;Translating;United States National Institutes of Health;uptake;Vaccine Design;Vaccines;virtual;Work

PROJECT_TITLE: Policy implementation for cancer control in Nigeria


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Digestive Diseases

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE This is a competitive renewal application for years 25-30 of a program to train postdoctoral investigators in basic and translational gastrointestinal research. Our T32 program’s primary goal is to develop future academic and scientific leaders of gastroenterology research by training promising MD, MD/PhD, DVM, DVM/PhD and PhD postdoctoral scientists to become independent laboratory-based and translational investigators focused on clinically relevant gastrointestinal research topics. Our training program has a robust pipeline of highly qualified applicants who undergo comprehensive interdisciplinary research training and career development that prepares them well for sustained, impactful independent research careers.

PI_NAMEs: SHEIKH, SHEHZAD Z. (contact)

PROGRAM_OFFICER_NAME: SERRANO, KATRINA JANE

PROJECT_TERMS: Gastroenterology;Research Training

PROJECT_TITLE: Gastroenterology Research Training


ADMINISTERING_IC: TW

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Clinical Research;Dental, Oral, and Craniofacial Disease;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: SEATTLE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: This proposal is to establish the Northern Pacific Global Health Leadership, Education, And Development for Early-career Researchers (NPGH LEADERs) Consortium – a research training program directed by the University of Washington in partnership with the Universities of Hawaii, Michigan and Minnesota with international partnerships in Cameroon, Ghana, India, Kenya, Liberia, Nepal, Peru, Thailand, and Uganda. The goal of this Consortium is to provide outstanding mentored research training to U.S. and LMIC post-doctoral and U.S. pre-doctoral trainees at international partner institutions in order to create the next generation of independent global health scientists and leaders.

PI_NAMEs: DATTA, DIBYADYUTI ;JOHN, CHANDY C.;MOYER, CHERYL A.;NERURKAR, VIVEK RAMCHANDRA;PRASAD, SHAILENDRA ;ZUNT, JOSEPH RAYMOND (contact)

PROGRAM_OFFICER_NAME: HAYES, UNJA

PROJECT_TERMS: Address;Cameroon;career;Cost Sharing;Country;Development;Education;Educational Curriculum;Ensure;Fellowship;Funding;Ghana;global health;Grant;Hawaii;HIV;Income;India;Indiana;Kenya;Leadership;Liberia;Maps;Mentors;Michigan;Minnesota;Names;National Institute of Dental and Craniofacial Research;Nepal;next generation;novel;Peru;Postdoctoral Fellow;pragmatic implementation;Process;Productivity;Protocols documentation;Publications;recruit;Research;Research Personnel;Research Project Grants;Research Training;Resource-limited setting;Scientific Inquiry;Scientist;skills;Thailand;Training;Training Activity;Uganda;Underrepresented Minority;Universities;Washington

PROJECT_TITLE: NPGH LEADERs - NIDCR - Asafu-Adjaye, Sillah

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(58)-R]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Cancer;Clinical Research

ORG_CITY: NOTRE DAME

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF NOTRE DAME

ORG_STATE: IN

PHR: Project Narrative: Asparaginase is used to treat common types of blood cancer in children. We will develop a test that doctors in low- and middle-income countries can use to find bad quality asparaginase before it is given to patients.

PI_NAMEs: LIEBERMAN, MARYA  (contact)

PROGRAM_OFFICER_NAME: DIVI, RAO L

PROJECT_TERMS: Administrative Supplement;Africa South of the Sahara;Amino Acid Substitution;asparaginase;Biological;Cells;chemotherapy;Color;Complex Mixtures;cost;Data;Detection;drug quality;Formulation;Goals;Hematopoietic Neoplasms;Hospitals;Human Resources;interest;Libraries;low and middle-income countries;machine learning method;Malignant Childhood Neoplasm;Malignant Neoplasms;Measures;Methods;Modification;parent project;Patients;Pharmacologic Substance;point of care;Post-Translational Protein Processing;Proteins;Proteome;Proteomics;Reader;Research Personnel;Residual state;response;screening;Techniques;Technology;Testing;Therapeutic;Time;United States National Institutes of Health

PROJECT_TITLE: Point of use detection of low-quality pharmaceutical asparaginase


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Coronaviruses;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases

ORG_CITY: NEW ORLEANS

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: Project Narrative – Overall The Tulane National Primate Research Center (TNPRC) has a mission to improve human and animal health through basic and applied biomedical research. The Center serves as a national resource for biomedical research that requires the use of nonhuman primates. Hundreds of NIH-funded investigators each year rely on the resources of the TNPRC to conduct their research.

PI_NAMEs: HAMM, L LEE (contact)

PROGRAM_OFFICER_NAME: BUHRING, BETTINA D

PROJECT_TERMS: 2019-nCoV;Accreditation;Aging;animal care;Animal Model;animal resource;Animals;applied biomedical research;Area;aspirate;Automation;Award;base;biocontainment facility;Biomedical Research;biomedical resource;career development;Cellular Immunology;Chronic;Communities;comorbidity;Containment;Contracts;COVID-19;COVID-19 pandemic;data centers;Dedications;Development;Education;Electronics;Emerging Communicable Diseases;Employee;empowerment;energy efficiency;Engineering;Environment;equity, diversity, and inclusion;evidence base;Faculty;Funding;Generations;Grant;Growth;Health;Health Sciences;HIV/AIDS;Human;imaging facilities;improved;industry partner;Infection;Infrastructure;Institution;Investments;Laboratories;Leadership;Lighting;Louisiana;Lung;Macaca;medical schools;Methods;Mission;Modeling;mouse model;Mus;National Institute of Allergy and Infectious Disease;nonhuman primate;operation;outreach;Pathogenicity;Performance;PET/CT scan;Play;Post-Acute Sequelae of SARS-CoV-2 Infection;Postdoctoral Fellow;Primates;Private Sector;programs;Public Health Schools;quality assurance;Quality Control;recruit;Request for Applications;Research;Research Personnel;Resources;response;Role;SARS-CoV-2 infection;Schools;Science;Socialization;Speed;square foot;Strategic Planning;success;System;Technology;therapeutic evaluation;Therapeutic Studies;Time;Training;Training Activity;Training and Education;Tropical Medicine;Tuberculosis;undergraduate student;United States National Institutes of Health;Universities;Update;vaccine evaluation;Vaccines;Vision;Work

PROJECT_TITLE: Socialization Enclosures Supporting HIV/AIDS-Related Research in SPF Macaques

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(41)-P]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;HIV/AIDS;Infectious Diseases

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Narrative This administrative supplement application seeks support to renovate space to house SIV infected animals assigned to AIDS studies, enhance our ability to provide social housing and exercise space for animals while assigned to AIDS research and facilitate behavioral testing on AIDS projects at the Emory National Primate Research Center (ENPRC). ENPRC’s mission is to conduct and support innovative biomedical and behavioral research by Core and Affiliated Scientists in order to improve the health and well-being of human and nonhuman primates.

PI_NAMEs: THADHANI, RAVI  (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Administrative Supplement;animal facility;Animal Housing;animal resource;Animal Testing;Animal Welfare;Animals;Area;base;Basic Science;behavior test;Behavioral;Behavioral Research;Biocompatible Materials;Biology;Biomedical Research;Breeding;cognitive neuroscience;cognitive testing;Communities;Custom;Data;data resource;design;Development;Discipline;Ensure;Environment;Exercise;experience;Faculty;flexibility;Funding;Future;Genetic;Goals;graduate student;Grant;Growth;Health;HIV-associated neurocognitive disorder;HIV/AIDS;Housing;Human;Humanities;Immunology;improved;Infrastructure;innovation;International;Knowledge;Length;Light;Macaca mulatta;medical specialties;member;Mental disorders;Microbiology;Mission;Modernization;Motor;multidisciplinary;Nervous System Disorder;Neuropharmacology;Neurosciences;nonhuman primate;Pathology;Personal Satisfaction;Postdoctoral Fellow;preference;Primates;Procedures;programs;Protocols documentation;Publications;Reporting;Research;Research Personnel;Research Project Grants;research study;Research Support;Resources;Role;Running;Scientist;Services;SIV;social;Socialization;Testing;Time;training opportunity;Translational Research;Transplantation;undergraduate student;United States National Institutes of Health;Universities;Visit

PROJECT_TITLE: Renovation to expand and enhance NHP housing for HIV/AIDS research at the Emory NPRC


ADMINISTERING_IC: LM

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Bioengineering;Data Science;Disability Research;Hearing Loss

ORG_CITY: PITTSBURGH

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Deaf and Hard of Hearing DHH persons are highly underrepresented in the research community, making up less than 1% of STEM Doctorate recipients. To address this disparity, the University of Pittsburgh (Pitt) and Gallaudet University (GU) will partner to create the Accessible and Inclusive Biomedical Informatics and Data Science (AIBIDS) program which is unique for its focus on empowering both DHH students and persons from other underrepresented groups in the sciences to lead biomedical informatics and data science research. The program will increase the inclusion and accessibility of biomedical informatics and data science research through authentic, accessible, and inclusive mentored research internships with experienced faculty and near- peer mentors to a highly diverse group of undergraduate and Masters level students.

PI_NAMEs: ARORA, GAURAV SURESHKUMAR;BOYCE, RICHARD DAVID (contact)

PROJECT_TERMS: Address;Administrative Supplement;Adult;American Sign Language;bilingualism;Biological Sciences;biomedical informatics;Communities;computer science;Computer software;Country;Data;Data Science;deaf;Disparity;Doctor of Philosophy;empowerment;Engineering;experience;Faculty;Funding;hard of hearing;Hearing;Individual;Internships;Language;Lead;Learning;Mathematics;Mentors;peer coaching;Persons;physical science;Polycystic Ovary Syndrome;programs;Public Health;recruit;Reporting;Research;Resources;Science;Site;skills;Students;symposium;System;Technology;Training;Training Programs;undergraduate student;Underrepresented Populations;United States;Universities;Woman;Work

PROJECT_TITLE: Building Accessible and Inclusive Paths for Students in Biomedical Informatics and Data Science- Sup 3


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Microbiome;Nutrition

ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

ORG_STATE: CA

PHR: PROJECT NARRATIVE The gut microbiota plays a role in protecting humans from disease, digesting food, and shaping immune system function. This project will investigate bacterial mechanisms that control why microbial community composition differs from one individual to another. A deeper understanding of these genes and pathways will inform design of personalized probiotics to treat diseases where the gut microbiota is perturbed.

PI_NAMEs: WOLF, ASHLEY ROBIN (contact)

PROGRAM_OFFICER_NAME: KEANE-MYERS, ANDREA

PROJECT_TERMS: Actinobacteria class;Atherosclerosis;Bacteria;Biology;Carbon;Chronic;Communities;Complex;Computer Analysis;Consumption;Correlative Study;design;Diet;Disadvantaged;Disease;dysbiosis;Environment;Enzymes;Escherichia coli;Evolution;Food;Genes;Growth;gut bacteria;gut microbiome;gut microbiota;Heterogeneity;human disease;immune system function;Individual;Intestines;Knowledge;Laboratories;Link;Measures;Metabolic;Metabolic Pathway;microbial;microbial community;microbiota;Mus;Non-Insulin-Dependent Diabetes Mellitus;Nutrient;Nutrient availability;Pathway interactions;Probiotics;Regulation;Regulatory Pathway;Repression;Research;Role;Shapes;single-cell RNA sequencing;Source;Therapeutic

PROJECT_TITLE: Regulation of carbon utilization in gut-resident bacteria

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-GGG-X(55)R]


NIH_SPENDING_CATS: Digestive Diseases;Nutrition;Pediatric

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE This Program is directly relevant to child health and development in training the next generation of scientists who will generate the advances essential for improving the quality of life and survival rates of children and adolescents with gastrointestinal, liver and nutrition-related disorders. Further, this training program represents an investment in the future of public health in general, as the multidisciplinary, intensive and innovative training provided by this Program will educate the leaders, teachers, and professional role models who will determine the direction and contributions of American medicine domestically and throughout the world, particularly as relates to pediatric gastroenterology, hepatology and nutrition.

PI_NAMEs: BAYRER, JAMES  (contact)

PROJECT_TITLE: Training Program in Pediatric Gastroenterology/Nutrition


FUNDING_MECHANISM: OTHERS

NIH_SPENDING_CATS: Precision Medicine

ORG_CITY: WASHINGTON

ORG_NAME: PYXIS PARTNERS LLC

ORG_STATE: DC

PHR: Pyxis Partners employs a strategic, engagement-centered approach that prioritizes collaboration and long-term sustainability. Our engagement strategy encompasses both community and researcher engagement activities, facilitating and implementing tailored initiatives that bridge the gap between different parties invested in health research. This project advances public health by strengthening engagement strategies that increase awareness of and participation in the All of Us Research Program, among researchers and community members alike. Through targeted messaging, expanded visibility, and trusted partnerships, Pyxis Partners and collaborators will continue to grow public trust, improve research accessibility, and contribute to the data resource. These efforts will ultimately enhance research relevance and impact.

PI_NAMEs: ROBLES-SCHRADER, GRISEL MARIE (contact)

PROGRAM_OFFICER_NAME: CROSBY, YONG RAY

PROJECT_TERMS: All of Us Research Program;Communities;Enrollment;Participant;Provider

PROJECT_TITLE: Community, Participant and Provider Engagement, Enrollment and RetentionBuilding and Sustaining Relationships to Increase Diversity in the All of Us Research Program participant community


ORG_CITY: BIRMINGHAM

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: This is an application for the Administrative Supplement to the currently active R35GM148158 grant entitled “DNA replication and cytokinesis”. The Administrative Supplement will allow us to purchase a new Synergy H1 plate reader that will greatly facilitate and advance our studies and workflow. The purchase of new equipment required for the project and associated research expenses will provide the necessary investment into the research-oriented economy.

PI_NAMEs: CHESNOKOV, IGOR N (contact)

PROGRAM_OFFICER_NAME: REDDY, MICHAEL K

PROJECT_TERMS: Administrative Supplement;Basic Science;Biological Models;Biological Sciences;Cells;Complex;Cytokinesis;Cytoskeleton;Data;Detection;DNA;DNA biosynthesis;Drosophila genus;Ensure;Equipment;Eukaryota;Eukaryotic Cell;flexibility;Fluorescence;Funding;Future;Generations;Goals;Grant;Human;Investments;Light;luminescence;mutant;parent grant;Positioning Attribute;preservation;protein complex;Protein Complex Subunit;protein function;Proteins;Reader;Research;Role;synergism;System;Time;Tissues;United States National Institutes of Health

PROJECT_TITLE: DNA Replication and Cytokinesis.

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Emerging Infectious Diseases;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunization;Infectious Diseases;Pediatric;Prevention;Rare Diseases;Social Determinants of Health;Substance Misuse;Tuberculosis;Vaccine Related;Women's Health Research

PHR: NARRATIVE Research on HIV and related infections has improved the treatment and prevention of disease, but much more needs to be done to control the epidemic. The proposed Clinical Trials Unit will join together the most active HIV clinical research sites in Baltimore, Maryland, Pune, and Chennai, India, to optimize patient-oriented research and to access key populations affected by this epidemic for participation in clinical trials.

PI_NAMEs: FLEXNER, CHARLES W.;GUPTA, AMITA  (contact)

PROGRAM_OFFICER_NAME: TUCKER, JENESE

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Adolescent;Adult;Affect;African American population;AIDS clinical trial group;AIDS prevention;Area;Baltimore;care providers;Caring;Child;Childhood;cis-female;clinical care;Clinical Pharmacology;Clinical Research;Clinical Research Protocols;clinical research site;Clinical Trials;Clinical Trials Network;Clinical Trials Unit;cohesion;Color;Communicable Diseases;Communication;Communities;community advisory board;comorbidity;disorder prevention;Distance Learning;Education;Enrollment;Epidemic;epidemic response;experience;Funding;Government;Health;Hepatitis;high risk;HIV;HIV prevention trials network;HIV vaccine;HIV Vaccine Trials Network;HIV/TB;Home;Human Subject Research;Immunology;improved;India;Infant;Infection;Infrastructure;innovation;Institution;Institutional Review Boards;International;International Maternal Pediatric Adolescent AIDS Clinical Trials;intravenous drug use;Latinx;Leadership;Maryland;Media Campaign;medical schools;men who have sex with men;Mentorship;Microbicide Trials Network;Mission;National Institute of Allergy and Infectious Disease;operation;Participant;patient oriented research;Population;Poverty;Pregnant Women;Prevention Research;Process;Productivity;programs;Protocols documentation;Provider;Publications;Recording of previous events;recruit;Research;research facility;Research Personnel;research study;Resource Sharing;Resources;Science;Scientific Advances and Accomplishments;Scientist;sexually active;Site;smartphone application;social media;Structure;Substance abuse problem;substance user;synergism;System;Therapeutic;Training;transgender;transgender women;treatment research;Tuberculosis;Tuberculosis Vaccines;Underrepresented Populations;United States National Institutes of Health;Universities;Viral hepatitis;web portal

PROJECT_TITLE: Johns Hopkins University Baltimore India Clinical Trail Unit (JHUBI CTU)


ED_INST_TYPE: UNIVERSITY-WIDE

ORG_CITY: TAMPA

ORG_NAME: UNIVERSITY OF SOUTH FLORIDA

ORG_STATE: FL

PHR: Project Narrative G protein coupled receptors (GPCRs) are targeted by more than 30% of FDA approved drugs. Understanding the interactions between ligands, receptors, and transducers, including G proteins, GRKs, and b-arrestins, are important for drug developments. The acquisition of this proposed equipment will not only enhance our capacity of investigating the interactions between ligands, different conformational states of the A2AR receptor, and G proteins that are proposed in the parent award, but also expand our ability to study other GPCRs and their interactions with various molecules in the future.

PI_NAMEs: YE, LIBIN  (contact)

PROGRAM_OFFICER_NAME: LEWIS, MECHELLE MAYLEBEN

PROJECT_TERMS: ADORA2A gene;Arrestins;Binding;Biological Assay;Complex;digital tool;drug development;Drug Screening;Equipment;equipment acquisition;experimental study;FDA approved;foster parent;Future;G protein coupled receptor kinase;G Protein-Coupled Receptor Signaling;G-Protein-Coupled Receptors;GTP-Binding Proteins;Individual;instrumentation;Isotope Labeling;Kinetics;Knock-out;Label;Ligands;Molecular Conformation;Mutagenesis;mutant;Nucleotides;parent project;Pharmaceutical Preparations;Physiological;Plasma;Process;radioligand;receptor;Receptor Activation;Research;response;Role;Series;Signal Transduction;Sodium Chloride;Structure;Surface;Transducers;Work

PROJECT_TITLE: The Role of Intermediate Conformations in G Protein-coupled Receptor Signaling


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics

ORG_CITY: FORT COLLINS

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: COLORADO STATE UNIVERSITY

PHR: PROJECT NARRATIVE Plasmids are engineered pieces of DNA that are used for biological research and for manufacturing biologic drugs and therapeutics. Despite the central importance of plasmids to biomedical research and development, the scientific community does not have a standardized, validated and secure infrastructure for associating the physical DNA molecules with the electronic records that describe them. We are proposing to develop a new digital certificate technology that will permanently label the DNA molecules themselves with an identifier that will connect them to standardized electronic documents describing their sequence, function, history, and other essential information allowing scientists to use them in a reproducible, safe, and secure manner.

PI_NAMEs: PECCOUD, JEAN M (contact)

PROGRAM_OFFICER_NAME: NGUYEN, HAN

PROJECT_TITLE: Supplement: Development of a technology to certify engineered DNA molecules

STUDY_SECTION: BDMA

STUDY_SECTION_NAME: Biodata Management and Analysis Study Section[BDMA]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Primary Immunodeficiencies;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative Major gaps remain in our understanding of how the immune system recognizes and limits the growth of pathogens at the epithelial border and this proposal will provide new insights into how the CD40-CD40L interaction directs mucosal immunity to infection. The proposed studies leverage a newly tractable pathogen model that shows remarkable specificity to ECs and provides robust in vivo readouts of infection, control, and protection. The mechanisms discovered in the course of this program will be broadly relevant to the study of diseases of the intestinal tract of infectious, inflammatory and malignant etiology where CD40L has been implicated.

PI_NAMEs: HUNTER, CHRISTOPHER A (contact);STRIEPEN, BORIS

PROGRAM_OFFICER_NAME: HUDSPETH, KELLY

PROJECT_TERMS: Cell surface;Chronic;Communication;Cryptosporidium;Disease;enteric infection;Epithelium;Etiology;Gene Transfer Techniques;genetic approach;Growth;Human;Immune;Immune system;Immunity;in vivo;Infection;Inflammatory;insight;Interferon Type II;Intestinal Diseases;Malignant - descriptor;Mediating;Modeling;mouse model;Mucosal Immunity;Mus;novel;Outcome;Parasites;Parasitic infection;pathogen;Population;Production;programs;protective effect;Resistance;Resistance to infection;Role;Specificity;Sterility;T cell response;T-Cell Activation;T-Lymphocyte;Testing;TNFRSF5 gene;TNFSF5 gene;x-linked Hyper-IgM Syndrome

PROJECT_TITLE: The role of CD40L in resistance to enteric infection


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Cancer;Cervical Cancer;Clinical Research;Dissemination and Implementation Research;HIV/AIDS;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Women's Health Research

ORG_DEPT: OBSTETRICS & GYNECOLOGY

PHR: Project Narrative AVIVA Chatbot 2.0 integration for enhanced communication is a supplement of a parent U01 which focuses on increasing HPV screening access among WLWH. It aims to train, evaluate, and integrate a customized large language models (LLMs)-based question-answering generative AI engine into an existing AI chatbot that is designed to respond to questions, and clear doubts of WLWH about cervical cancer screening (CCS) in three HIV clinics in Nigeria, as a measure to improve CCS access. The generative AI has human-level creativity ability to generate ideas on a possible wide range of questions based on learnings from previously collected data and its integration enables a chatbot to cater to inherent variability and linguistic variations in the way chatbot end users ask the same questions.

PI_NAMEs: AWOLUDE, OLUTOSIN ;EZECHI, OLIVER CHUKWUJEKWU;FLOWERS, LISA C. (contact);GAYDOS, LAURA M;OGUNSOLA, OLABANJO OKUNLOLA

PROGRAM_OFFICER_NAME: ALARO, JAMES R

PROJECT_TERMS: Adoption;Affect;Africa South of the Sahara;Age;Artificial Intelligence;artificial intelligence model;Awareness;Behavioral;Cancer Burden;Cervical;Cervical Cancer Screening;Cervix Uteri;chatbot;Clinic;Collaborations;Communication;Communities;Complex;Cost Analysis;Country;Creativeness;Data;Data Set;Databases;design;Development;Diagnosis;diagnostic accuracy;Education;Ensure;epidemiological model;Evaluation;follow-up;Fostering;Future;General Population;generative artificial intelligence;girls;global health;Grant;Gynecologic;Health Personnel;Health Status;Health system;Healthcare;High Prevalence;HIV;HIV Seronegativity;Home;HPV screening;HPV-High Risk;Human;Image;implementation barriers;implementation facilitators;implementation process;improved;Individual;Institution;interest;International;Intervention;Journals;Knowledge;large datasets;large language model;Learning;Lesion;Linguistics;Location;Maintenance;male;Malignant Breast Neoplasm;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Measures;Mentors;Methods;Modality;Modeling;Nigeria;Nigerian;Nurses;open source;Parents;Pattern;Persons;Phase;Population;premalignant;Prevention;Process;programs;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Reporting;reproductive;Research;Research Personnel;Research Project Grants;Resource-limited setting;Resources;response;Risk;Rural;satisfaction;scale up;screening;screening services;Series;Services;Site;social;Stains;Surveys;Target Populations;Technology;technology development;Training;treatment services;Uncertainty;Universities;uptake;Urban Community;Validation;Variant;virtual healthcare;Visual;Woman;Writing


NIH_SPENDING_CATS: Cancer;Data Science;Networking and Information Technology R&D (NITRD);Pediatric;Pediatric Cancer;Rare Diseases

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PI_NAMEs: DIGIOVANNA, JACK ;HEATH, ALLISON ;RESNICK, ADAM CAIN (contact)

PROGRAM_OFFICER_NAME: PAPANICOLAOU, GEORGE

PROJECT_TERMS: Annual Reports;anti-cancer research;Area;Bioinformatics;Child;Childhood Brain Neoplasm;cloud based;Collaborations;Communication;computer science;Computer software;Data;Data Coordinating Center;data ecosystem;data resource;data sharing;Development;Ensure;Ethics;Funding;Future;Genomics;Genotype-Tissue Expression Project;Goals;Human BioMolecular Atlas Program;Human Resources;Infrastructure;interoperability;large scale data;Modification;Neurosciences Research;Pediatric Hospitals;Persons;Philadelphia;Policies;programs;Progress Reports;Publications;Reproducibility;Research;Research Personnel;response;Scientist;software development;Teleconferences;tool;United States National Institutes of Health;Visualization;Work;working group

PROJECT_TITLE: Kids First Data Resource Center (KFDRC): Harnessing Data-Driven Opportunities in the Present on behalf of the Future of Common Fund Data Ecosystem (CFDE)


NIH_SPENDING_CATS: Genetics;Infectious Diseases

PHR: Project Narrative Pseudomonas aeruginosa, which infects immunocompromised people, can communicate among its own populations using a signaling system called quorum sensing. We seek to understand how quorum sensing evolves over time and influences interactions with other microbes, with the idea that these studies will eventually lead to potential new treatments for bacterial infections.

PI_NAMEs: DANDEKAR, AJAI  (contact)

PROJECT_TERMS: Bacteria;Bacterial Infections;Behavior;Cells;Coculture Techniques;Communication;Cooperative Behavior;Environment;Evolution;Funding;Gene Expression;Generations;Genetic;human pathogen;Immunocompromised Host;Individual;intercellular communication;interest;Knowledge;Microbe;microbial;Microbial Genetics;Modeling;Molecular Biology;Molecular Genetics;National Institute of General Medical Sciences;Organism;Persons;Population;Population Sizes;Pseudomonas aeruginosa;quorum sensing;response;Signal Transduction;Social Behavior;Social Interaction;System;Therapeutic;Time;Work


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Breast Cancer;Cancer;Lung;Women's Health Research

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: RICE UNIVERSITY

PHR: Project Narrative After metastasis to the lungs, breast cancer cells are exposed to unique forces and matrix proteins that are not present at the primary tumor. My previous findings indicate that cyclic stretching, mimicking breathing dynamics within a 3D model of the early metastatic niche, can drive tumor cells into a state of growth arrest without widespread cell death. Because stromal cells are the key contributor of matrix composition and architecture, my goal is to evaluate the unique fibroblast subtypes conditioned by breast cancer cells at different stages of the metastatic cascade and characterize how the tissue changes they produce alter the metastatic progression of disseminated breast cancer cells.

PI_NAMEs: LIBRING, SARAH  (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: 3-Dimensional;Apoptosis;Architecture;Atomic Force Microscopy;Biomimetics;Breast Cancer Cell;Breathing;Cancer Biology;cancer cell;Cancer Cell Growth;cancer diagnosis;cancer subtypes;Cell Death;Cell model;Cell secretion;cell type;Cells;Cessation of life;Clinical;Communication;Complex;conditioning;Coupled;defined contribution;Desmoplastic;Development;Disease;Doctor of Philosophy;Educational process of instructing;effective therapy;Endocrine;Engineering;Epithelium;experimental study;Exposure to;extracellular;Extracellular Matrix;extracellular vesicles;Fibroblasts;Fibronectins;Flow Cytometry;Foundations;Glycoproteins;Goals;Growth;improved;in vivo;insight;interest;Lead;Link;Lung;lung volume;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant Neoplasms;mechanical force;mechanical load;mechanical properties;Mechanics;mechanotransduction;Mentors;Mesenchymal;metabolic rate;Metastatic breast cancer;Metastatic Neoplasm to the Lung;Methods;migration;Modeling;Morbidity - disease rate;mortality;Neoplasm Metastasis;neoplastic;neoplastic cell;Nonmetastatic;novel;Output;paracrine;Pathway interactions;Patients;Periodicity;Phenotype;phenotypic biomarker;Positioning Attribute;Postdoctoral Fellow;prevent;Primary Neoplasm;Production;Proliferating;Proteins;Proteomics;Research;Research Personnel;Role;Signal Transduction;single-cell RNA sequencing;Site;skills;Stretching;Stromal Cells;Structure of parenchyma of lung;Survival Rate;targeted treatment;Testing;therapy development;three dimensional cell culture;three-dimensional modeling;Tissue Engineering;Tissues;Training;transmission process;Tumor Cell Migration;tumor microenvironment;Universities;Vesicle;Western Blotting;Woman;Work

PROJECT_TITLE: Characterizing CAFs in Metastasis as a Function of Breast Cancer Cell Phenotype


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;HIV/AIDS;Health Services;Infectious Diseases;Lung;Lung Cancer;Palliative Care;Prevention;Rare Diseases;Tobacco;Tobacco Smoke and Health

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Project Narrative The supplemental implementation science training and data collection activities proposed will leverage the Quit4Life+ (5U01CA261624-03) and HIVAM (D43TW009759) projects’ research teams (e.g. research trainees, interviewers, field supervisors, data/records managers) and existing study partners (e.g. district officers, clinical supervisors, clinicians, nurses, counselors) to build implementation science capacity and better evaluate cancer-related interventions and services within local, regional, and national health systems. By adapting and piloting an implementation assessment tool, we aim to assess the effectiveness and feasibility of cancer prevention and care interventions for people living with HIV in Uganda and Zambia. This project will have important implications for policymakers, community leaders, and healthcare workers and ultimately guide future implementation science studies and interventions designed to strengthen cancer health service delivery throughout the African region and in other LMICs.

PI_NAMEs: ARINAITWE, JIM ;WIPFLI, HEATHER L (contact)

PROGRAM_OFFICER_NAME: RICCIARDONE, MARIE D

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Administrative Supplement;Administrator;Adopted;Advanced Malignant Neoplasm;Africa;Africa South of the Sahara;African;Aging;AIDS related cancer;Alcohols;anti-cancer research;Anti-viral Therapy;Assessment tool;Behavior Therapy;Behavioral;cancer care;Cancer Control;Cancer Intervention;Cancer Model;cancer prevention;cancer therapy;career;Caring;Cessation of life;Clinic;Clinical;Collaborations;Communities;comorbidity;Country;Data;Data Collection;Early Intervention;Educational Curriculum;effective intervention;Effectiveness;effectiveness evaluation;Evaluation;evidence base;Evidence based practice;experience;Fostering;Fred Hutchinson Cancer Research Center;Funding;Future;future implementation;global health;Goals;Health behavior;health care delivery;Health Personnel;Health Services Accessibility;Health system;Healthcare Systems;HIV;Hodgkin Disease;implementation barriers;implementation evaluation;implementation research;implementation science;improved;Infrastructure;Institution;interest;Intervention;intervention delivery;Interviewer;low and middle-income countries;malignant mouth neoplasm;Malignant neoplasm of anus;Malignant neoplasm of liver;Malignant neoplasm of lung;Malignant Neoplasms;medical schools;Modeling;Monitor;Morbidity - disease rate;mortality;Nurses;Outcome;parent project;Performance;Persons;Phase;Physical activity;pilot test;policy implication;Policy Maker;Population;Preparation;prevent;preventive intervention;Process;Professional counselor;programs;Provider;Public Health;Public Health Schools;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Records;reduce tobacco use;Research;Research Design;Research Infrastructure;Research Personnel;Research Project Grants;Research Training;Resources;response;Risk;Risk Factors;scale up;service delivery;Services;systems research;Testing;theories;therapy design;Throat Cancer;tobacco control;Tobacco use;tool;Training;Training and Education;Training and Infrastructure;Translational Research;Uganda;Unhealthy Diet;United States National Institutes of Health;Universities;Zambia

PROJECT_TITLE: Building Implementation Science Research Capacity to advance cancer prevention and care in Uganda and Zambia


NIH_SPENDING_CATS: Bioengineering

ORG_CITY: CHICAGO

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: ILLINOIS INSTITUTE OF TECHNOLOGY

ORG_STATE: IL

PHR: The BioCAT resource will continue to provide state-of-the-art facilities with unique capabilities for muscle/fiber diffraction and macromolecular SAXS to the bio-medical and structural biology community. The purpose of this proposed administrative supplement is to new X-ray optical components that will provide better performance and mitigate obsolescence.

PI_NAMEs: IRVING, THOMAS C (contact)

PROGRAM_OFFICER_NAME: GERSHENSON, ANNE

PROJECT_TERMS: Administrative Supplement;Advisory Committees;Aging;Amyloid;beamline;Biological;biological systems;Biology;Biophysics;Biotechnology;Characteristics;Charge;Collaborations;Communities;Complex;Computer software;Connective Tissue;Data;Data Analyses;Dedications;Development;Ensure;Equilibrium;Equipment;experience;Fiber;fibrous protein;Funding;Grant;Illinois;improved;Individual;Infrastructure;instrumentation;interest;Laboratories;Leadership;Ligands;macromolecule;Maintenance;Modification;Molecular;Molecular Biology;Muscle;National Center for Research Resources;National Institute of General Medical Sciences;Nucleic Acid Folding;Nucleic Acids;operation;Optics;outreach;Performance;Persons;Photons;Physics;Policies;Principal Investigator;professor;Proteins;Publications;Recruitment Activity;repaired;Research;Research Personnel;Research Project Grants;Research Technics;Resources;Roentgen Rays;Sampling;Schedule;Science;Shapes;Source;structural biology;Structure;Students;synchrotron radiation;Synchrotrons;System;Technology;Time;tool;Training;Training Activity;training opportunity;United States National Institutes of Health;Visit

PROJECT_TITLE: K-B focusing mirror system and monochromator upgrade for the  BioCAT Beamline 18ID at the Advanced Photon Source.


ORG_CITY: HOUSTON

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: Project Narrative Cervical cancer is a significant health issue in Mexico and screening participation rates are low particularly among women experiencing access barriers. The IMSS Maquiladora HPV Screening Program aimed to address this by offering self-sampling kits to under-screened women in maquiladoras, however, there were wide variations in program use and effectiveness highlighting the need to understand implementation barriers. Our research seeks to identify these barriers, explore patient and provider perspectives, and design strategies to enhance program adoption, implementation, effectiveness, and maintenance ultimately contributing to improved cervical cancer control in Mexico.

PI_NAMEs: FERNANDEZ, MARIA EULALIA (contact);LAJOUS, MARTIN ;UNGER-SALDA�A, KARLA

PROGRAM_OFFICER_NAME: CORREA-MENDEZ, MARGARITA

PROJECT_TERMS: Address;Administrative Supplement;Adopted;Adoption;aged;Appointment;Cancer Control;Cancer Etiology;Caring;Characteristics;Clinic;Clinical;Colposcopy;Consolidated Framework for Implementation Research;cost effectiveness;Country;Cytology;design;Diagnostic;digital platform;Effectiveness;effectiveness outcome;Electronic Mail;Equity;experience;Female;Floor;follow-up;Fright;Funding;Goals;Health;Health care facility;health care service;Health Personnel;Healthcare;Healthcare Systems;HPV positive;HPV screening;Human Papillomavirus;Human Resources;implementation barriers;implementation design;implementation determinants;implementation efforts;implementation evaluation;implementation facilitators;implementation fidelity;implementation outcomes;implementation research;implementation science;implementation strategy;improved;Institution;Integrated Health Care Systems;Interview;Latin America;Logic;low and middle-income countries;Maintenance;Malignant neoplasm of cervix uteri;Malignant Neoplasms;manufacturing facility;Maps;Methods;Mexican;Mexico;Modeling;Morbidity - disease rate;mortality;National Cancer Institute;Needs Assessment;Outcome;Pain;Parents;Patients;Population;primary care clinic;Process;Program Effectiveness;programs;Provider;Public Health;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Reporting;Research;Sampling;screening;Screening for cancer;screening participation;screening program;Social Security;Structure;success;Test Result;Testing;Texas;Time;Training;training opportunity;Underserved Population;uptake;Variant;Woman;Women's mortality;Work;Working Women;Workplace

PROJECT_TITLE: Implementation Evaluation of a Workplace Self-Sampling HPV Detection Program within the Mexican Social Security Institute


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Depression;Mental Health;Neurodegenerative;Neurosciences;Prevention;Sleep Research

ORG_CITY: IOWA CITY

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Project Narrative The goal of these studies is to determine whether tau accumulation in serotonin neurons causes affective and sleep disturbances, leading to chronic sleep deprivation and hyperexcitability in serotonin neurons and accelerating the spread of tau pathology to the entorhinal cortex. The resulting loss of 5-HT input to the EC also enhances excitability of EC neurons that project to the hippocampus, promoting spread to this region and precipitating cognitive decline. Ultimately, this investigation may identify neural substrates underlying the early non-cognitive symptoms of AD which could lead to better treatments for this devastating disease.

PI_NAMEs: MARCINKIEWCZ, CATHERINE ANNE (contact)

PROGRAM_OFFICER_NAME: MACKIEWICZ, MIROSLAW

PROJECT_TERMS: Acceleration;Affective;affective disturbance;Age;age related neurodegeneration;Agreement;Alzheimer's Disease;American;Appearance;attenuation;Automobile Driving;Behavior;Behavioral;Behavioral Symptoms;Biological Assay;Brain;Brain region;Chronic;Clinical Data;Cognitive;Cognitive deficits;Data;Denervation;depressive behavior;depressive symptoms;Deterioration;Development;Disease;Disinhibition;dorsal raphe nucleus;early detection biomarkers;Early Diagnosis;Electroencephalography;Electrophysiology (science);entorhinal cortex;Etiology;Exhibits;Expectancy;Fiber;genetic manipulation;Goals;Hippocampus;hTau Mice;Human;Hyperactivity;Impaired cognition;in vivo;Individual;Induced Neurons;Intervention;Investigation;Measures;Mediating;Memory;Memory impairment;Mental Depression;Microinjections;mild cognitive impairment;Monitor;mouse model;Mus;mutant;Nerve Degeneration;neural;neural circuit;Neurobehavioral Manifestations;neurofibrillary tangle formation;Neurofibrillary Tangles;neuromechanism;neuronal excitability;Neurons;neuroprotection;Onset of illness;optogenetics;Pathology;Periodicity;Photometry;prevent;Quality of life;Receptor Signaling;Research;Risk;Role;Scanning;Selective Serotonin Reuptake Inhibitor;Serotonin;Serotonin Receptor 5-HT2A;Signal Transduction;Sleep;Sleep Deprivation;Sleep Disorders;Sleep disturbances;Sleep Fragmentations;sleep quality;Slice;Symptoms;Synapses;tau aggregation;tau Proteins;tau-1;Tauopathies;Testing;Three-Dimensional Imaging;transmission process

PROJECT_TITLE: Sleep and affective disturbances in the etiology of Alzheimer's disease

STUDY_SECTION: CDIN

STUDY_SECTION_NAME: Chronic Dysfunction and Integrative Neurodegeneration Study Section[CDIN]


NIH_SPENDING_CATS: HIV/AIDS;Infectious Diseases

ORG_CITY: SAN ANTONIO

ORG_NAME: TEXAS BIOMEDICAL RESEARCH INSTITUTE

PHR: Project Narrative This proposed P51 supplement will meet an urgent need to upgrade ABSL2 macaque holding space to support HIV/AIDS related research. Over the last decade several ABSL2 buildings and rooms have been removed from service and taken offline at SNPRC due to failing HVAC systems. This supplement will provide HVAC upgrades to eight ABSL2 rooms to bring them back into service to support rhesus macaque holding at SNPRC.

PI_NAMEs: SCHLESINGER, LARRY S. (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Acute;Address;Administrative Supplement;Adolescent;Affect;aged;Animals;Area;Back;Biomedical Research;Breeding;Charge;co-infection;Communicable Diseases;Communities;comorbidity;Funding;germ free condition;HIV;HIV vaccine;HIV/AIDS;improved;Incidence;Individual;Infrastructure;Institution;Macaca;Macaca mulatta;mortality;next generation;nonhuman primate;pandemic disease;parent project;pathogen;Pathogenesis;pressure;Primates;Productivity;programs;Research;Research Personnel;Research Project Grants;Research Support;Resources;Rhesus;Running;Sales;Scientist;Services;Site;System;therapeutic development;United States;United States National Institutes of Health;vaccine development;Weaning

PROJECT_TITLE: The Southwest National Primate Research Center Supplement- Infrastructure improvements of ABSL2 holding areas


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric

PHR: PROJECT NARRATIVE TCF20-associated neurodevelopmental disorder (TAND) is a devastating neurological disease caused by mutations in a high-risk autism gene TCF20, yet the disease pathogenesis and reversibility remain elusive. I have recently found that TCF20 regulates key neuronal gene expression in mouse models and therefore propose to dissect the molecular, neuronal, and temporal function of TCF20 during brain development, particularly focusing on its role in activity-dependent signaling pathways. This study will reveal the neuronal and molecular pathogenesis of TAND, determine the critical developmental window for therapeutic intervention, and shed light on how activity-dependent signaling regulates brain development under healthy and disease conditions.

PI_NAMEs: ZHOU, JIAN  (contact)

PROGRAM_OFFICER_NAME: DOSS, ARGENIA LANISHA NECOLE

PROJECT_TERMS: Address;Adult;Animals;Ataxia;autism spectrum disorder;autism symptoms;Award;Behavior;Behavioral;Behavioral Assay;behavioral study;Binding;Biological Assay;Brain;cell type;Cells;Cellular biology;Child;Chromatin;Cleavage Under Targets and Release Using Nuclease;Clinical;Cognitive;Collaborations;college;Complex;Computer Analysis;conditional knockout;Data;Defect;Development;Developmental Process;Disease;DNA Binding;Electrophysiology (science);Environment;Faculty;Foundations;Frequencies;Future;gamma-Aminobutyric Acid;Gene Expression;gene induction;Genes;Genetic;Genetic Engineering;genome-wide;Grant;Growth;high risk;Immediate-Early Genes;Impairment;in vivo;inhibitory neuron;Institution;Intellectual functioning disability;knock-down;Label;Large-Scale Sequencing;Learning;loss of function mutation;LoxP-flanked allele;Manuscripts;Measures;Mediating;Medical center;Medicine;Mentors;Methyl-CpG-Binding Protein 2;Modeling;Molecular;Morphology;mouse genetics;mouse model;Mus;Muscle hypotonia;Mutation;Nervous System Disorder;neurobehavioral;Neurobehavioral Manifestations;neurodevelopment;Neurodevelopmental Disorder;neurogenetics;Neurons;neurophysiology;Neurosciences;neurotransmission;novel;Pathogenesis;Pathway interactions;Phase;Phenotype;Physiological;Play;Positioning Attribute;postnatal;postsynaptic;programs;promoter;Proteins;Reporter;Reporting;Research;risk variant;Role;Seizures;Shapes;Signal Pathway;Signal Transduction;single cell analysis;single nucleus RNA-sequencing;skills;social;Stimulus;Symptoms;synaptogenesis;System;Techniques;Testing;Texas;Therapeutic Intervention;Time;tool;Training;transcription factor;Whole-Cell Recordings;Work;Writing

PROJECT_TITLE: The role of Tcf20 in activity-dependent inhibitory signaling and autism spectrum disorder pathogenesis

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-2 Study Section [NST-2]


ORG_CITY: BOSTON

ORG_NAME: TUFTS UNIVERSITY BOSTON

ORG_STATE: MA

PHR: Project Narrative  Maintenance of ER protein homeostasis (proteostasis) is a fine balancing act between protein synthesis, folding and degradation. Mis-regulation of any one of these processes leads to perturbed ER proteostasis and activation of the unfolded protein response (UPR). ER stress and UPR activation is a major contributor to many human diseases. Here we investigate mechanisms that prevent protein mis-folding in the ER with a focus on how protein synthesis is regulated at the ER.

PI_NAMEs: RAMAN, MALAVIKA  (contact)

PROGRAM_OFFICER_NAME: PHILLIPS, ANDRE W

PROJECT_TERMS: ATF6 gene;Binding;Binding Proteins;Biogenesis;biological adaptation to stress;Biotinylation;Cell Death;Cells;Chemistry;cofactor;Competence;Coupled;Cues;Cystic Fibrosis;Data;Defect;Disease;endoplasmic reticulum stress;Equilibrium;Estrogen Receptor Status;Funding;Genetic Transcription;human disease;innovation;insight;interest;Label;Maintenance;Mass Spectrum Analysis;Mediating;Messenger RNA;misfolded protein;Modification;Molecular;molecular imaging;Nerve Degeneration;Null Lymphocytes;p97 ATPase;Pathway interactions;polypeptide;Polyribosomes;Positioning Attribute;prevent;Process;programs;protein aggregation;Protein Biosynthesis;protein degradation;protein misfolding;Proteins;Proteome;Proteomics;proteostasis;proteostasis loss;Puromycin;Quality Control;Repression;Research;response;Ribosomal Proteins;ribosome profiling;Ribosomes;Role;Signal Transduction;single molecule;stressor;System;Testing;Therapeutic;Transcript;transcription factor;translational impact;Translational Regulation;Translational Repression;Translations;Ubiquitin;Up-Regulation;Work;XBP1 gene

PROJECT_TITLE: Mechanisms regulating ER Proteostasis


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biotechnology;Brain Disorders;Dementia;Depression;Major Depressive Disorder;Mental Health;Mental Illness;Natural Products;Neurodegenerative;Neurosciences;Post-Traumatic Stress Disorder (PTSD);Serious Mental Illness;Substance Misuse

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: PROJECT NARRATIVE Compounds capable of promoting neuroplasticity, such as ketamine and serotonergic psychedelics, have enormous potential for treating neuropsychiatric and neurodegenerative diseases characterized by cortical atrophy, but their hallucinogenic effects limit their clinical scalability. Recently, our group discovered that it is possible to engineer non-hallucinogenic analogs of psychedelics capable of promoting neuroplasticity after a single administration and producing sustained therapeutic effects across disease indications. The research described here seeks to establish new synthetic strategies for accessing plasticity-promoting compounds as well as methods for evaluating their efficacy, safety, and mechanisms of action—information that will ultimately lead to the development of new treatments for diseases such as depression, posttraumatic stress disorder, substance use disorder, Alzheimer’s disease, and Parkinson’s disease, among others.

PI_NAMEs: OLSON, DAVID E (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TERMS: addiction;Affect;Alzheimer's Disease;Amendment;Amphetamines;analog;Anhedonia;Animal Model;anti-depressive agents;Anxiety;Area;Atrophic;Autopsy;Benchmarking;Biological Assay;Biosensor;Bipolar Disorder;blood-brain barrier crossing;Brain Diseases;Brain-Derived Neurotrophic Factor;Cellular Assay;Central Nervous System Agents;cerebral atrophy;Chemicals;Clinical;comorbidity;Dendritic Spines;density;Development;Dimensions;Disease;drug discovery;efficacy evaluation;Engineering;Equipment;Evaluation;Exclusion;Fright;Functional disorder;G-Protein-Coupled Receptors;Generations;Goals;Growth;Hallucinations;Hallucinogens;human imaging;Iboga;Impaired cognition;improved;Impulsivity;in vivo;innovation;Ketamine;Knowledge;Lead;Ligands;Major Depressive Disorder;Medical;Medicine;Mental Depression;Methods;mimetics;Molecular;Moods;Motivation;National Institute of General Medical Sciences;Natural Products;Neurodegenerative Disorders;Neuroglia;Neuronal Plasticity;Neurons;neuropsychiatric disorder;Neurosciences;next generation;novel;parent grant;parent project;Parkinson Disease;Pathologic;Patients;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacologic;Pharmacologic Substance;Play;Post-Traumatic Stress Disorders;Prefrontal Cortex;Probability;programs;Property;rational design;repaired;Research;Resources;Rewards;Route;Safety;scaffold;Schizophrenia;small molecule;Structure;Structure-Activity Relationship;Study models;Substance Use Disorder;success;Symptoms;Synapses;System;Therapeutic;Therapeutic Effect;tool;treatment response;Tropanes;Tryptamines;Work

PROJECT_TITLE: Supplement: Chemical and Molecular Tools for Modulating GPCR Function


ADMINISTERING_IC: DA

FUNDING_MECHANISM: NON SBIR/STTR CONTRACTS

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Aging

ORG_CITY: CALVERTON

ORG_NAME: INFORMATION MANAGEMENT SERVICES, INC.

PI_NAMEs: MEAGHER, KEVIN  (contact)

PROJECT_TERMS: Aging;biobank;Data;System

PROJECT_TITLE: NIA CENTRAL BIOREPOSITORY  - DATA COORDINATION AND SYSTEMS MANAGEMENT


NIH_SPENDING_CATS: Biotechnology;HIV/AIDS;Immunization;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: KENSINGTON

ORG_NAME: ADVANCED BIOSCIENCE LABORATORIES, INC.

PI_NAMEs: MACK, FRED  (contact)

PROJECT_TERMS: Adjuvant;Aluminum;Aluminum Hydroxide;Antigens;cGMP production;Clinical Trials;Contractor;Contracts;Databases;Development;Documentation;efficacy study;Equipment and supply inventories;HIV vaccine;HIV-1;Human;immunogenicity;In Vitro;Investigational Drugs;Laboratories;Laboratory Animals;manufacture;National Institute of Allergy and Infectious Disease;Phase;plasmid DNA;preclinical development;Preclinical Testing;Preventive vaccine;product development;Production;Proteins;Protocols documentation;prototype;quality assurance;Quality Control;research clinical testing;Testing;Toxicology;Vaccines;Viral Vector

PROJECT_TITLE: Production of Aluminum Based Adjuvants


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Eye Disease and Disorders of Vision;Infectious Diseases;Networking and Information Technology R&D (NITRD);Rare Diseases;Telehealth

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Trachoma is the leading infectious cause of blindness in the world. This project aims to develop a mobile software application to enhance trachoma monitoring activities by allowing eye photography and integration of visual acuity and refractive error assessment. The mobile application will be field-tested and validated in diverse settings in Peru to ensure broad generalizability.

PI_NAMEs: KEENAN, JEREMY DAVID (contact);LESCANO, ANDRES G

PROGRAM_OFFICER_NAME: GOVER, TONY DOUGLAS

PROJECT_TERMS: 3D Print;Address;Adopted;Affect;Anterior;Area;automated algorithm;Blindness;California;Cellular Phone;Certification;Child;Chlamydia trachomatis;Clinical;Collaborations;Communities;Computer software;Cornea;Data;Data Collection;data platform;Development;Diagnosis;Diagnostic tests;Ensure;experience;Eye;feasibility testing;field study;fighting;flexibility;Foundations;Goals;Health;Health Personnel;Health Resources;Health Surveys;Hospitals;Human;Human Resources;imaging Segmentation;Individual;Lighting;Location;mobile application;Modality;Modeling;Monitor;neglected tropical diseases;ophthalmic examination;Pan American Health Organization;Participant;Persons;Peru;Photography;population based;Printing;programs;Public Health;Questionnaires;Recommendation;Refractive Errors;remote communities;remote grading;Research;Research Personnel;Resource-limited setting;sample collection;Sampling;San Francisco;Sensitivity and Specificity;Structure;success;Surveys;System;Telemedicine;Testing;tool;Trachoma;Universities;Update;uptake;user-friendly;validation studies;Variant;Vision Screening;Visual Acuity;Work;World Health Organization

PROJECT_TITLE: Integrating smartphone photography for trachoma, smartphone visual acuity assessment, and mobile autorefraction to enhance community-based public health monitoring

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Clinical Research;Disability Research;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: ATLANTA

ORG_NAME: GEORGIA INSTITUTE OF TECHNOLOGY

PHR: Project Narrative Changes in the human brain following early blindness have been widely documented, but our understanding of the mechanisms underlying this remarkable neuroplasticity is very limited. My goal is to examine the anatomical, neural, and computational constraints that allows blind individuals to meet the extraordinary challenge of learning to navigate and interact with the environment using remaining senses. This will not only facilitate the development of targeted rehabilitation programs for blind individuals, but will also help us understand the processes underlying acquisition of specialized skills (including reading and arithmetic) during development.

PI_NAMEs: PARK, WOON JU  (contact)

PROGRAM_OFFICER_NAME: WIGGS, CHERI

PROJECT_TERMS: Adult;Anatomy;Area;Arithmetic;Auditory;auditory stimulus;Award;Behavioral;blind;Blindness;Brain;Brain region;Compensation;density;design;Development;Diffusion Magnetic Resonance Imaging;diffusion weighted;Environment;Equilibrium;experience;flexibility;Functional Magnetic Resonance Imaging;gamma-Aminobutyric Acid;Goals;Human;Individual;Learning;Link;Literature;Magnetic Resonance Imaging;Magnetic Resonance Spectroscopy;Mathematics;Measurement;Measures;Mediating;Mentors;Modality;Modeling;Motion;neural;Neuroanatomy;neurochemistry;Neuronal Plasticity;Neurons;Neurophysiology - biologic function;Neurotransmitters;Noise;novel;Outcome;Perception;Performance;Positioning Attribute;Process;programs;Property;Psychophysics;Reading;recruit;Recycling;Rehabilitation therapy;Research;Research Personnel;response;Rest;Role;Sensory;sensory cortex;Signal Transduction;skills;spatiotemporal;spectroscopic imaging;Techniques;Testing;Tissues;Training;Universities;Vision;visual deprivation;Visual Motion;visual processing;Visually Impaired Persons;Washington;white matter;Work

PROJECT_TITLE: Anatomical, Neural, and Computational Constraints On Sensory Cross-Modal Plasticity Following Early Blindness


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Nutrition

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Project narrative Peroxisomes participate in lipid metabolism and scavenging of reactive oxygen species in almost all nucleated cells and play critical roles in most major organs, liver, heart and pancreas, and in brain where they are especially important in maintaining the myelin sheath around axons, and synthesis of ether lipids in neurons and glia. Aging, and CNS diseases show loss of the balance of oxidative stress and lipid metabolism mediated by changes in peroxisomal proteins, of which ABCD3, the subject of this proposal, is one of the most abundant and important for import of fatty-acids, bile salt and ether lipid precursors. We seek an atomic level basis for the function and changes in associations of ABCD3 from aging and Alzheimer’s model cell lines using cryo electron microscopy and electron tomography.

PI_NAMEs: GUPTA, MEGHNA  (contact)

PROGRAM_OFFICER_NAME: CARTER, CHRISTY

PROJECT_TERMS: 3-Dimensional;Acyl Coenzyme A;Adrenoleukodystrophy;Affect;Affinity;age related;age related neurodegeneration;age-related disease;Aging;aging related;Alzheimer's Disease;Alzheimer's disease model;analog;Antibodies;Area;ATP Hydrolysis;ATP phosphohydrolase;ATP-Binding Cassette Transporters;Axon;Bile Acids and Salts;Binding;Biochemical Reaction;Biogenesis;Biological Assay;Biology;Biophysics;Biotinylation;Brain;branched chain fatty acid;Catalytic Domain;cell age;Cell Line;Cell membrane;Cell Physiology;Cells;Central Nervous System;Central Nervous System Diseases;Coenzyme A;Complex;Confocal Microscopy;Coupled;Coupling;Cryo-electron tomography;Cryoelectron Microscopy;cryogenics;Cytoplasm;Cytoplasmic Receptors;Cytosol;Defect;Demyelinations;Diabetes Mellitus;Disease;electron tomography;Enzymes;Equilibrium;Ethers;Eukaryotic Cell;Event;experience;fatty acid metabolism;fatty acid transport;Fatty Acids;Fostering;Functional disorder;Gene Deletion;gene repression;Generations;Genetic;Goals;Heart;Hereditary Disease;Homeostasis;Human;Ions;knock-down;Length;lens;Libraries;lipid metabolism;Lipids;Liver;loss of function;Mass Spectrum Analysis;Measures;Mediating;Medium chain fatty acid;member;Membrane;Membrane Proteins;Mentors;Metabolic Diseases;Metabolic Pathway;Metabolism;Mitochondria;Molecular;Molecular Chaperones;Molecular Conformation;Molecular Structure;Morphology;mutant;Mutation;Myelin Sheath;NADH;Neurodegenerative Disorders;Neuroglia;Neurons;Nucleotides;Organ;Organelles;Orthologous Gene;oxidation;Oxidative Stress;Pancreas;Pathogenesis;peroxisome;peroxisome lumen;peroxisome membrane;Phase;Plants;Play;preservation;Process;protein structure;Proteins;Protocols documentation;Reaction;Reactive Oxygen Species;Reporting;Research;Research Personnel;Resolution;response;Role;Scanning Electron Microscopy;Scientist;Side;Site;Specificity;Streptavidin;Structure;Sulfhydryl Compounds;Testing;tool;Training;verdin photosensitizer;Visualization;Zellweger Syndrome

PROJECT_TITLE: Peroxisomal fatty acid metabolism in genetic and age-related disorders


NIH_SPENDING_CATS: Rare Diseases

ORG_CITY: LITTLE ROCK

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIV OF ARKANSAS FOR MED SCIS

ORG_STATE: AR

PHR: PROJECT NARRATIVE  Intracellular membrane trafficking that mediates the delivery of secretory and endocytic cargo proteins and lipids is critical for a range of cellular functions, including protein secretion, post-translational modifications, signaling, cell polarization, and cell maintenance. Defects in membrane trafficking can underlie or exacerbate many human diseases, including cancer, diabetes, Alzheimer’s disease, cystic fibrosis, Hermansky-Pudlak syndrome, and congenital disorders of glycosylation. In this project, we will uncover the molecular basis for protein-protein interactions and regulations of key components of the Golgi trafficking machinery and create a novel cellular model to study congenital disorders of glycosylation.

PI_NAMEs: LUPASHIN, VLADIMIR V (contact)

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TERMS: Affect;Alzheimer's Disease;autosome;base;Binding;Categories;Cell Line;Cell Maintenance;Cell model;Cell Physiology;Cells;Congenital disorders of glycosylation;Cystic Fibrosis;Defect;Development;Diabetes Mellitus;Disease;Docking;Environment;Enzymes;Fibroblasts;flexibility;glycosylation;Golgi Apparatus;Hermanski-Pudlak Syndrome;Human;human disease;Impairment;induced pluripotent stem cell;Intracellular Membranes;Kinetics;Label;Lipids;Liver;Malignant Neoplasms;Mediating;Membrane;Microcephaly;Modeling;Molecular;Mutation;Neurologic;novel;Occupations;Patients;polarized cell;Population;Post-Translational Protein Processing;Process;protein protein interaction;Protein Secretion;Proteins;receptor;Recycling;Regulation;Set protein;Signal Transduction;SNAP receptor;stem cells;success;Symptoms;Testing;therapy development;Tissues;trafficking;Treatment Protocols;Vesicle

PROJECT_TITLE: Characterization of mammalian COG complex-interacting Golgi trafficking machinery


NIH_SPENDING_CATS: Aging;Cardiovascular;Clinical Research;Health Services;Heart Disease;Patient Safety

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

PHR: PROJECT NARRATIVE Heart failure (HF) is the leading cause of hospitalization in older adults and represents an enormous public health burden. Despite the contributions of countless studies, national campaigns, and financial incentives, high rates of rehospitalization continue to put enormous strain on the U.S. healthcare system and on those suffering from the disease. We propose to integrate the strengths of life course theory, data, and methods to examine the longitudinal patterns and predictors of hospitalization in older adults diagnosed with HF.

PI_NAMEs: DUPRE, MATTHEW E. (contact)

PROGRAM_OFFICER_NAME: SERRA, MONICA CHRISTINE

PROJECT_TERMS: Address;Admission activity;Adult;Aging;Attention;Behavioral;burden of illness;Caring;Characteristics;Classification;Clinical;clinical practice;Clinical Research;cohort;cost;critical period;Data;design;Diagnosis;Disease;Electronic Health Record;experience;Face;financial incentive;Goals;Health;Health and Retirement Study;Healthcare Systems;Heart failure;hospital admission rate;Hospitalization;hospitalization rates;Hospitals;human old age (65+);improved;indexing;Intervention;Investments;Knowledge;Length of Stay;Life Cycle Stages;longitudinal dataset;Longitudinal Studies;Medicare;Medicare claim;Methods;Mission;Modeling;older adult;Patient risk;Patients;Pattern;Persons;Population;Predictive Factor;prevent;Probability;prospective;psychosocial;Public Health;Quality of Care;Recurrence;Reproducibility;Research Personnel;response;Risk;Sampling;socioeconomics;theories;Time;tool;Treatment Failure;United States National Institutes of Health

PROJECT_TITLE: A Life Course Approach to Identify Risks of Hospitalization in Older Adults with Heart Failure

STUDY_SECTION: HSQE

STUDY_SECTION_NAME: Health Services: Quality and Effectiveness Study Section[HSQE]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Machine Learning and Artificial Intelligence;Mental Health;Neurosciences;Pediatric;Prevention

ORG_CITY: SAN DIEGO

ORG_NAME: SAN DIEGO STATE UNIVERSITY

PHR: PROJECT NARRATIVE Because preschool-age irritability that persists into school-age predicts lifespan mental disorder and poorer functional outcomes, identifying the neural mechanisms by which children persist vs. remit in irritability is paramount to intervene in the earliest phase of the clinical cascade. Our overall goal is to identify reward- and inhibition-related neural pathways that characterize persistence vs. remission of early childhood irritability and may be targets for future novel preventive efforts. Our project is significant because it will pave the way for precision medicine for irritability: providing the right treatment (based on neural mechanisms) to the right people (children who will persist in irritability), at the right time (preschool age, before irritability problems worsen).

PI_NAMEs: DOUGHERTY, LEA R;WIGGINS, JILLIAN LEE (contact)

PROGRAM_OFFICER_NAME: PACHECO, JENNIFER LYNN

PROJECT_TERMS: 5 year old;6 year old;Accounting;Adult;Age;age related;Amygdaloid structure;Anger;Anxiety;Brain;brain behavior;Child;Child Rearing;Childhood;Chronic;Clinical;Cognition;contextual factors;Corpus striatum structure;Data;Development;Disease;Disease remission;early childhood;Early Diagnosis;Early identification;Early Intervention;economic outcome;Evaluation;experience;Feedback;financial incentive;first grade;follow-up;Friends;Frustration;Functional Magnetic Resonance Imaging;functional outcomes;Future;Goals;Image;Impairment;innovation;Internet;Interview;life span;Life Stress;Link;Machine Learning;machine learning method;Maintenance;Measures;Mental Depression;Mental disorders;Methods;middle childhood;neural;neural circuit;Neural Inhibition;neural network;Neural Pathways;neuroimaging;neuromechanism;Neurophysiology - biologic function;novel;Nursery Schools;Parents;Participant;Pattern;Persons;Phase;precision medicine;Prefrontal Cortex;prevent;Preventive;Psychopathology;recruit;Reporting;Research Domain Criteria;resilience;reward processing;Rewards;Risk;Risk Factors;Role;School-Age Population;Services;sex;Sex Ratio;socioeconomics;stressor;suicidal;support network;Symptoms;Temperament;Time;Variant;Work

PROJECT_TITLE: Neural mechanisms of risk and resilience in early childhood irritability

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Antimicrobial Resistance;Biotechnology;Immunization;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_CITY: SAINT LOUIS

ORG_NAME: VAXNEWMO, LLC

PHR: PROJECT NARRATIVE The goal of the project is to accelerate preclinical development of a vaccine for the prevention of Klebsiella pneumoniae infections. We have developed a vaccine targeting more than 80% of K. pneumoniae isolates encountered in the clinic and seek to validate its ability to elicit a protective immune response.

PI_NAMEs: HARDING, CHRISTIAN  (contact)

PROGRAM_OFFICER_NAME: RITCHIE, ALEC

PROJECT_TERMS: Acceleration;Animal Model;Antibiotic Resistance;Antibiotics;Antibodies;Antibody Response;Awareness;Bacteria;Bacterial Infections;Bacterial Polysaccharides;bactericide;Biological Assay;Bioreactors;carbapenem resistance;Carbapenems;Carrier Proteins;Cells;Cephalosporins;Cessation of life;chemical conjugate;Clinic;Clinical;combat;Communities;comparison control;Complex;Conjugate Vaccines;cross immunity;Development;Disease;Dose;Drug resistance;efficacy evaluation;Encapsulated;Enzyme-Linked Immunosorbent Assay;Enzymes;Epitopes;Escherichia coli;Europe;Formulation;Future;Generations;Genetic;genetic information;Glean;glycosylation;Goals;Healthcare;Immune;Immune response;Immunity;Immunization;Immunize;immunogenicity;Immunoglobulin Class Switching;Immunoglobulin G;Immunoglobulin M;Immunologics;Individual;Infection;Inferior;Investments;Klebsiella;Klebsiella pneumoniae;Life;Light;Link;Lipopolysaccharides;manufacture;Meta-Analysis;Methods;microbial;Minor;Mus;novel;O Antigens;Oryctolagus cuniculus;Ozone;pathogen;pathogenic bacteria;Patients;Phase;Placebos;Polysaccharides;pre-clinical;preclinical development;prevent;Prevention;Process;Production;Resistance;resistant Klebsiella pneumoniae;response;Scheme;Serotyping;Serum;Structure;Surface;System;Technology;Testing;Vaccinated;Vaccination;vaccine candidate;Vaccine Design;vaccine development;vaccine efficacy;vaccine immunogenicity;Vaccine Production;Vaccines;Work

PROJECT_TITLE: A multivalent O-antigen bioconjugate vaccine for the prevention of Klebsiella pneumoniae infections

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AIDC-P(11)]


ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE The parent award research aims to understand how cells survive and adapt under stress, which could lead to new treatments for cancer and other diseases. By acquiring a benchtop sequencing instrument, we will be able to study these cellular responses more comprehensively and cost-effectively, accelerating our progress towards identifying novel therapeutic targets to enhance health and reduce illness.

PI_NAMEs: SHAFFER, SYDNEY ;ZHANG, NANCY R (contact)

PROGRAM_OFFICER_NAME: NGUYEN, HAN

PROJECT_TERMS: Acceleration;Agreement;Avidity;Award;Bar Codes;base;Budgets;Cancer cell line;Cancer Model;cancer therapy;Cell Survival;Cells;Chemistry;Contract Services;cost;Cost Savings;Cost Sharing;Data;data quality;Disease;Elements;Ensure;Epigenetic Process;Equipment;experience;Funding;Genetic Transcription;Goals;Health;improved;instrument;Letters;multiple omics;new therapeutic target;next generation sequencing;parent project;Research;Research Support;response;sequencing platform;Stress;stressor;System;transcriptomics

PROJECT_TITLE: Multiomic single cell and spatial interrogation of mechanisms in cellular adaptation to stress


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Biomedical Imaging;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Fibromyalgia;Mental Health;Neurosciences;Pain Research

ORG_CITY: CHARLESTOWN

ORG_NAME: SPAULDING REHABILITATION HOSPITAL

PHR: The patient-clinician interaction is central to most therapies and is supported by key interpersonal mechanisms of action, though the neural underpinnings of this effect are mostly unknown. As previous research has implicated brain-to-brain concordance of the temporoparietal junction, a region known to be intimately linked with theory of mind processing, we will use hyperscanning functional MRI to evaluate the impact of targeted theory of mind training in fibromyalgia patients on brain-to-brain concordance and how such training can synergistically couple with acupuncture therapy.

PI_NAMEs: EDWARDS, ROBERT R;NAPADOW, VITALY  (contact)

PROGRAM_OFFICER_NAME: QUINLAN, ERIN BURKE

PROJECT_TERMS: Absence of pain sensation;Acupuncture Therapy;Behavioral;Brain;chronic pain management;chronic pain patient;chronic painful condition;Clinical;Cognitive;cognitive function;Combined Modality Therapy;Empathy;Facial Expression;Fibromyalgia;fibromyalgia patients;Functional Magnetic Resonance Imaging;improved;Institute of Medicine (U.S.);Link;Magnetic Resonance Imaging;Mediating;mental state;mentalization;neural;neural model;neuroimaging;neurophysiology;Nonpharmacologic Therapy;novel;novel therapeutics;Outcome;Pain;pain outcome;Pathway interactions;Patients;perspective taking;Protocols documentation;Provider;Publishing;Quality of life;Recommendation;Reporting;Research;Research Design;social;social communication;Social Functioning;theory of mind;Therapeutic;Training;Trust

PROJECT_TITLE: Impact of Theory of Mind Training on Brain-to-Brain Patient-Clinician Concordance

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(02)]


ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: WASHINGTON UNIVERSITY

PHR: Narrative: The looming crisis of antibiotic resistance and thus the inability to treat common infections is reaching a tipping point making development of new antibiotics imperative. This supplemental proposal will facilitate the further development of a new class of antibiotics that we have termed GmPcides, which are bactericidal against a wide range of Gram-positive pathogens. This supplement will identify the essential targets of GmPcide-induced cell death in MRSA as well as virulence determinants that are affected by GmPcide treatment in the murine skin and soft tissue infection model, supplementing the ongoing studies in the parent grant to identify viable lead compounds for clinical development.      !   !   !

PI_NAMEs: HULTGREN, SCOTT J. (contact)

PROGRAM_OFFICER_NAME: ERNST, NANCY L

PROJECT_TERMS: 2-hydroxypyridine;Acceleration;Affect;Antibiotic Resistance;antibiotic resistant infections;Antibiotics;antimicrobial;Antimicrobial Resistance;bactericide;Binding;Cell Count;Cell Death Induction;cellular targeting;Cessation of life;Chromosomes;Clindamycin;Clinical;clinical development;Clinical effectiveness;clinical efficacy;Collaborations;combat;Combating Antibiotic Resistant Bacteria;Defect;Development;Erythromycin;Essential Genes;experience;experimental study;Expression Library;falls;fitness;Funding;gene product;Generations;Genes;genetic approach;Genus staphylococcus;healing;improved;In Vitro;in vivo;Infection;Infectious Skin Diseases;innovation;Interdisciplinary Study;Laboratories;Lead;Libraries;Membrane Proteins;Methicillin Resistance;methicillin resistant Staphylococcus aureus;Modeling;Multi-Drug Resistance;Mus;mutant;Mutation;novel;novel antibiotic class;novel therapeutics;overexpression;parent grant;Parents;pathogen;Phase;programs;promoter;Property;Proteins;Public Health;public health intervention;Research;Resistance;scaffold;Skin;Soft Tissue Infections;Solubility;Staphylococcus aureus;Streptococcus;synergism;Techniques;Time;Toxic effect;Training;transposon sequencing;Ulcer;Universities;Up-Regulation;Vancomycin;Vancomycin resistant enterococcus;Vancomycin-resistant S. aureus;Virulence;Virulence Factors;Washington

PROJECT_TITLE: Innovative Strategies to Combat Antibiotic-resistant Infections


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Mental Health;Neurodegenerative;Neurosciences

ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: Project Narrative Aging is associated with deficits in trust-related decision making, contributing to the growing public health problem of elder fraud. This project will (i) characterize basic neurocognitive processes in learning to trust in aging; and (ii) determine if trust-related decision making can be optimized via neurofeedback training.

PI_NAMEs: EBNER, NATALIE C (contact);LIGHTHALL, NICHOLE ;WILSON, ROBERT C

PROGRAM_OFFICER_NAME: SUTTERER, MATTHEW

PROJECT_TERMS: Address;Adult;Affective;Age;age related;age related neurodegeneration;Aging;aging related;Alzheimer's Disease;Amygdaloid structure;Anterior;Arizona;Basic Science;brain behavior;cingulate cortex;Clinical;Cognition Disorders;Cognitive;cognitive function;cognitive process;computational neuroscience;Computer Models;Control Groups;COVID-19 pandemic;Cues;Data;Decision Making;distrust;Elderly;Emotional;experience;experimental study;Family history of;Financial Hardship;Florida;Foundations;Fraud;Functional Magnetic Resonance Imaging;Future;Gambling;Geriatric Assessment;Goals;Health;healthy aging;Human;human old age (65+);Impaired cognition;Impairment;improved;Individual;innovation;Insula of Reil;interdisciplinary approach;Intervention;Investigation;Iowa;Learning;Life;life span;Link;Measures;Mediating;Memory;Methodology;middle age;neural;neural circuit;neural correlate;Neurocognitive;neuroeconomics;neurofeedback;neuroimaging;neuromechanism;Neuropsychology;neurotransmission;novel;older adult;Older Population;Outcome;Pathology;Pathway interactions;phishing;Play;pre-clinical;Predisposition;Process;Public Health;Research;Research Project Grants;response;Risk;Role;Sampling;Signal Transduction;social;Social Interaction;Social Sciences;Societies;System;Techniques;Testing;theories;theory of mind;Time;Training;translational potential;Trust;trustworthiness;Up-Regulation;Update;Work;young adult

PROJECT_TITLE: Characterizing and modulating neurocognitive processes of learning to trust and distrust in aging

STUDY_SECTION: HCMF

STUDY_SECTION_NAME: Human Complex Mental Function Study Section[HCMF]


NIH_SPENDING_CATS: Genetics

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative Nonsense Mediated mRNA Decay (NMD) degrades both aberrant transcripts and “normal” transcripts with other specific features, impacting around 10% of the transcriptome. This project will investigate the biological roles and molecular functions of UPF3, a disease-linked core NMD factor, in both human cells and zebrafish development. Taken together, this study will help us understand how UPF3-activated NMD and transcriptional regulation is modulated, and elucidate connections between mRNA decay and transcriptional regulation.

PI_NAMEs: ARVOLA, RENE MARLENE (contact)

PROGRAM_OFFICER_NAME: STOKES, KALYNDA K

PROJECT_TERMS: Binding;Biological;Cell Nucleus;Cells;Compensation;Complex;Cytoplasm;Deposition;Disease;Event;Exons;Feedback;Genetic;Genetic Transcription;Histones;Human;Immunoprecipitation;in vivo;Link;Mammals;Mass Spectrum Analysis;Maternity leave;Mediating;member;messenger ribonucleoprotein;Messenger RNA;Molecular;mRNA Decay;Nuclear;Nuclear Import;nucleocytoplasmic transport;overexpression;paralogous gene;parent grant;Phase;Positioning Attribute;premature;Productivity;Proteins;Regulation;Reporter;Research;Research Training;response;Rest;Role;Terminator Codon;Transcript;Transcriptional Regulation;transcriptome;Work;Zebrafish;zebrafish development

PROJECT_TITLE: Investigating UPF3 paralog function in Nonsense-Mediated mRNA Decay and Genetic Compensation


NIH_SPENDING_CATS: Machine Learning and Artificial Intelligence

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE Mesenchymal stromal cells (MSCs) are promising for treating many challenging diseases, but they are difficult to produce due to rapid aging and loss of therapeutic functions during expansion. This proposal aims to develop an AI-based method to design drugs that delay MSC aging by controlling their biochemical signaling. Upon completion, this project will enable reproducible production of highly potent MSCs and advance our fundamental understanding of aging signaling in these cells.

PI_NAMEs: LIN, NEIL  (contact)

PROGRAM_OFFICER_NAME: WANG, PEGGY

PROJECT_TERMS: Address;Administrative Supplement;Aging;artificial intelligence method;artificial intelligence model;Biochemical;Cell Aging;Cell Therapy;Cells;Clinical;confocal imaging;DDR2 gene;design;Disease;Drug Design;EGF gene;Endoplasmic Reticulum;Fibroblast Growth Factor;FRAP1 gene;Histones;Image;In Vitro;innovation;live cell imaging;mesenchymal stromal cell;Metabolic;Metabolism;Microscope;Mitochondria;novel;parent project;Pathway interactions;Phototoxicity;Process;Production;Recurrence;Rejuvenation;Reproducibility;Research;Resolution;senescence;Signal Pathway;Signal Transduction;Subcellular structure;System;Therapeutic;training data

PROJECT_TITLE: AI-informed Signaling Factor Design for in vitro Rejuvenating Mesenchymal Stromal Cells


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics

ORG_CITY: COLLEGE PARK

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

ORG_STATE: MD

PHR: Development of the vertebrate embryo requires the production and distribution of broad types of molecules. This project uses uniquely sensitive technologies to understand how small molecules called metabolites contribute to the coordination of embryonic development.

PI_NAMEs: NEMES, PETER  (contact)

PROGRAM_OFFICER_NAME: WELLS, MELISSA LYNN

PROJECT_TERMS: Affect;Biological;Cell Differentiation process;Cells;Communication;Complex;Custom;Data;design;Development;Developmental Biology;Embryo;embryo cell;embryo stage 2;Embryonic Development;Folic Acid;Generations;Genes;Genetic Transcription;Germ Layers;Human Development;innovation;insight;Interdisciplinary Study;Knowledge;Laboratories;Mass Spectrum Analysis;Messenger RNA;Metabolic;Metabolism;metabolomics;Microscopy;Modeling;Molecular;Neural Tube Closure;next generation sequencing;Normal Cell;Pattern;Performance;Play;Post-Translational Protein Processing;Process;Production;programs;Proteins;Proteomics;Rana;Reaction;Reproducibility;Research;Resolution;Role;Scientist;small molecule;System;Tadpoles;Technology;Time;Tissues;tool;Transcript;transcriptomic profiling;Translations;vertebrate embryos;Vertebrates;Work;Xenopus;Xenopus laevis

PROJECT_TITLE: A Precision Cell-Sorter for Sub-Cellular Mass Spectrometry Discoveries: Metabolic Encoding of the Embryonic Body Plan


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Emerging Infectious Diseases;Infectious Diseases

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: EMORY UNIVERSITY

PHR: Public Health Relevance Statement Statistical and mathematical methods for the study of infectious diseases and for discovery and evaluation of interventions have become increasingly important. The Summer Institute in Statistics and Modeling in Infectious Diseases (SISMID) provides necessary and innovative training in statistical and mathematical modeling to students, postdoctoral fellows, and professionals. This research education program enables them to formulate research questions, analyze data, design studies, and model dynamics and evolution of infectious diseases including emerging infectious diseases relevant to important public health and biomedical research questions.

PI_NAMEs: DEAN, NATALIE EXNER (contact);LOPMAN, BENJAMIN A

PROGRAM_OFFICER_NAME: MOITRA, KAROBI

PROJECT_TERMS: Address;Award;Awareness;Basic Science;Bayesian Analysis;Biomedical Research;Bioterrorism;career;Case Study;Charge;Collection;Communicable Diseases;Computing Methodologies;Country;Data;Data Analyses;data streams;data visualization;design;Disease Outbreaks;dynamic system;Ebola;Education;education research;Educational process of instructing;Electronic Mail;Emerging Communicable Diseases;Epidemic;Epidemiology;Europe;Evaluation;Event;Evolution;experience;Faculty;Funding;genomic data;Goals;Government;graduate student;Grant;Home;Immunity;Immunology;improved;Industry;infectious disease evolution;infectious disease model;Infectious Diseases Research;Influenza;Influenza A Virus, H1N1 Subtype;innovation;Institution;Instruction;instructor;International;Intervention;Learning;Markov Chains;mathematical methods;mathematical model;mathematical sciences;Mathematics;Measurable;meetings;Mentors;Methods;microbiome;Modeling;Molecular Epidemiology;Names;National Institute of Allergy and Infectious Disease;next generation;novel;pandemic disease;Paper;Participant;pathogen;Persons;Population;Positioning Attribute;Postdoctoral Fellow;Probability;programs;Public Health;public health relevance;Reproducibility;Request for Proposals;Research;Research Design;Research Personnel;Research Project Grants;responsible research conduct;Scientist;Series;simulation;skill acquisition;skills;Statistical Methods;Statistical Models;statistics;Structure;Students;summer institute;Training;Training Activity;transmission process;Travel;United States;Universities;Virus;waiver;Washington;Western Africa;Writing;Zika Virus