PHR: PROJECT NARRATIVE Accumulating evidence associates heart disease with low levels of cardiac vagus nerve activity (low vagal outflow) resulting in autonomic imbalance, and that increased cardiac vagal outflow is cardioprotective. We will determine the molecular mechanisms active in central neurons producing normal vagal outflow and in the restoration of cardioprotective vagal activity.

PI_NAMEs: SCHWABER, JAMES  (contact);VADIGEPALLI, RAJANIKANTH

PROGRAM_OFFICER_NAME: TJURMINA, OLGA A

PROJECT_TERMS: Affect;Anatomy;antagonist;Anterior;Anterior Descending Coronary Artery;Arteries;Behavior;Biological Assay;Brain Stem;Cardiac;Cardiac health;cardioprotection;Cardiovascular system;Cell Nucleus;cohort;Complex;computational network modeling;Computer Analysis;Data;data integration;Data Set;Development;Dorsal;dorsal motor nucleus;druggable target;experience;experimental analysis;Extinction;Female;Gene Expression;gene regulatory network;Genes;Genetic Transcription;genomic platform;Heart;Heart Diseases;Hour;Hypertension;Immunohistochemistry;In Situ Hybridization;injury and repair;insight;interest;Intervention Studies;ischemic injury;Ischemic Preconditioning;laser capture microdissection;Left;Ligation;male;Mediating;Mediator;Messenger RNA;MicroRNAs;miRNA expression profiling;Molecular;molecular phenotype;Motor Neurons;multidimensional data;Myocardial Ischemia;nano-string;Neuroanatomy;neurogenetics;Neurons;neurophysiology;Pathologic;Pattern;Peripheral;pharmacologic;Phase;Phenotype;Physiological;Physiology;Process;protective effect;Rattus;Regulation;remote intervention;Reperfusion Injury;Research;response;restoration;Series;single-cell RNA sequencing;skills;Source;System;Systems Biology;Technical Expertise;Testing;Time;transcriptome sequencing;transcriptomic profiling;transcriptomics;Untranslated RNA;Vagus nerve structure

PROJECT_TITLE: Molecular Neurogenetics of the Brainstem Neuronal Source of Cardioprotective Vagal Outflow

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


ADMINISTERING_IC: DA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

ORG_CITY: MEMPHIS

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF TENNESSEE HEALTH SCI CTR

ORG_STATE: TN

PHR: The proposed research is relevant to public health and the missions of both NIH and NIDA because it will elucidate stress effects and pathways, as well as potential resilience-promoting protective factors, in relation to adolescent substance misuse for Black and White youth. Findings ultimately can help inform the development of tailored prevention and intervention efforts, thereby helping reduce health disparities in substance misuse and its adverse consequences.

PI_NAMEs: DEREFINKO, KAREN J (contact)

PROGRAM_OFFICER_NAME: DUNSTON, SHEBA KING

PROJECT_TERMS: 8 year old;addiction;Address;Adolescence;Adolescent;adverse outcome;Advocate;Affect;Age;alcohol use initiation;Alcohols;behavior observation;Birth;Black Populations;Black race;Buffers;Child;Child Rearing;Childhood;Cigarette;Clinic Visits;Communities;comparison group;County;COVID-19 impact;COVID-19 pandemic;Data;Development;Discrimination;early childhood;early life stress;Electronic cigarette;Equilibrium;ethnic minority population;experience;Exposure to;Funding;Goals;Health;Home visitation;Illicit Drugs;Intervention;Interview;Knowledge;Learning;Life;Life Stress;Link;Longitudinal cohort study;longitudinal design;Marijuana;Mediating;member;Methods;minority stress;Mission;Modeling;National Institute of Drug Abuse;Neurocognitive;next generation;Parents;Pathway interactions;Pattern;prenatal;prenatal exposure;Prevention;Prevention approach;Preventive;preventive intervention;promote resilience;protective factors;Psychopathology;Public Health;Questionnaires;racial minority population;recruit;Reduce health disparities;Research;Research Methodology;resilience;resilience factor;Risk;Sampling;Second Pregnancy Trimester;Sex Differences;social stigma;Social support;socioeconomic disadvantage;Stress;Stress and Coping;stressor;Structural Racism;Subgroup;substance misuse;Testing;theories;Time;traumatic event;United States National Institutes of Health;Woman;Work;Youth

PROJECT_TITLE: Life Stress Pathways and Resilience to Substance Misuse in Black and White Youth

STUDY_SECTION: SPIP

STUDY_SECTION_NAME: Social Psychology, Personality and Interpersonal Processes Study Section[SPIP]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: LOS ANGELES

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: Periodic paralysis is a rare inherited disorder of skeletal muscle in which recurrent episodes of severe weakness, and the risk of progressive weakness with loss of ambulation, are caused by mutations of ion channel genes. The defects in channel function resulting from these mutations are now known, but the mechanism by which transient attacks of paralysis are triggered by diet, stress, or exercise are poorly understood. We will use our genetically-engineered mouse models of periodic paralysis to explore the hypothesis that these transient episodes of weakness occur as a result of changes in the abundance of intracellular ions (sodium and chloride), and also determine whether channel defects lead to chronically altered intracellular ion content.

PI_NAMEs: CANNON, STEPHEN C. (contact)

PROGRAM_OFFICER_NAME: CARIFI, EMILY FORAN

PROJECT_TERMS: Acidosis;Acute;Affect;Alleles;Biological Assay;Biophysics;Biopsy;Bumetanide;Carbohydrates;Cells;Chlorides;Chronic;clinical phenotype;Clinical Trials;cold temperature;Computer Models;Computer Simulation;Coupled;Data;Defect;defined contribution;design;Development;Diet;Disease;Exercise;extracellular;Extravasation;Fasting;Fiber;Functional disorder;gain of function;Genes;Genetically Engineered Mouse;Goals;Hereditary Disease;Hour;Human;human data;Hyperkalemic periodic paralysis;Hypokalemic periodic paralysis;Impairment;improved;insight;Intervention;Investigation;Ion Channel;Ion Transport;Ions;Knock-in;Knock-in Mouse;Knowledge;Lead;Magnetic Resonance Imaging;Measurement;Microelectrodes;Missense Mutation;Modeling;mouse model;Mus;Muscle;Muscle Fibers;muscle stiffness;mutant;mutant mouse model;Mutant Strains Mice;Mutation;Myopathy;Myotonia;novel strategies;novel therapeutic intervention;Oocytes;Paralysed;Pathogenesis;Pathway interactions;Patients;periodic paralysis;Phenotype;Potassium Channel;Preclinical Testing;Predisposition;prevent;Prevention;programs;Pump;Recovery;Recurrence;Research;Resources;response;Rest;Risk;Sarcolemma;sensor;simulation;Skeletal Muscle;Sodium;Sodium Channel;Sodium Chloride;Specificity;Stress;symporter;symptom management;System;Testing;Therapeutic Intervention;therapy design;timeline;Validation;Variant;voltage

PROJECT_TITLE: Pathophysiology of Myotonia and Periodic Paralysis

STUDY_SECTION: SMEP

STUDY_SECTION_NAME: Skeletal Muscle and Exercise Physiology Study Section[SMEP]


ADMINISTERING_IC: GM

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: LITTLE ROCK

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIV OF ARKANSAS FOR MED SCIS

ORG_STATE: AR

PHR: PROJECT NARRATIVE This Training in Systems Pharmacology and Toxicology (T-SPaT) Program is designed for PhD students pursuing dissertation research projects in the pharmacological sciences at the University of Arkansas for Medical Sciences. A systems approach using in vivo animal models is necessary to establish efficacy, safety and the pharmacodynamic/pharmacokinetic profile of candidate drugs but there is a shortage of students trained in this area.

PI_NAMEs: PRATHER, PAUL L (contact)

PROGRAM_OFFICER_NAME: NELSON, SHAKIRA M

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - B[TWD-B]


ADMINISTERING_IC: HL

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Infectious Diseases;Lung;Orphan Drug;Pneumonia;Pneumonia and Influenza;Rare Diseases

ORG_CITY: RICHMOND

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: Exogenous surfactant has previously been shown to offer a clinical benefit in full-term infants, children and adolescents experiencing acute lung injury (ALI) or acute respiratory distress syndrome (ARDS), but has not been successfully applied in adults, most likely due to poor alveolar lung delivery efficiency of the current liquid bolus instillation procedure, which is often employed with invasive mechanical ventilation late in the development of ALI/ARDS. In this project, a new high efficiency synthetic lung surfactant powder aerosol product is developed (including delivery strategies, formulations and devices) that can be rapidly administered early and often in ALI/ARDS development during less invasive forms of ventilation support, such as high-flow nasal cannula therapy. The proposed synthetic lung surfactant inhalation product will reduce the required administered dose by an order of magnitude, reduce aerosol treatment times in adults from >10 hours to minutes, and substantially reduce the projected cost per treatment.

PI_NAMEs: LONGEST, P. WORTH  (contact)

PROGRAM_OFFICER_NAME: ZHOU, GUOFEI

PROJECT_TERMS: Acute Lung Injury;Acute Respiratory Distress Syndrome;Address;Adolescent;Adult;aerosolized;Aerosols;Affect;Air;Air Pressure;Alveolar;alveolar epithelium;Alveolus;analog;Animal Experiments;Animal Model;Animals;Area;aspirate;Bacterial Infections;Bacterial Pneumonia;Bolus Infusion;Cannulas;Chemical Surfactants;Chest;Child;Childhood;Clinical;Clinical Trials;comparative efficacy;Contusions;cost;COVID-19;cytokine;design;Development;Device or Instrument Development;Devices;Dose;Dryness;Early treatment;Edema;efficacy testing;Epithelial Cells;Excipients;Exhalation;Exhibits;experience;experimental study;Failure;Formulation;fungal pneumonia;Gases;Goals;Growth;Hour;Human;Hypoxemia;improved;In Vitro;in vivo;Infant;Inflammation;Inhalation;Inhalators;Intubation;Lead;Leukocytes;Liquid substance;Lung;lung injury;Mechanical ventilation;meter;Methods;Modeling;mortality;Near Drowning;Nebulizer;Nose;Outcome;particle;Patients;peptide analog;Performance;Periodicity;pharmacologic;Phospholipids;Population;Powder dose form;preclinical development;pressure;Procedures;Production;Proteins;Pulmonary Surfactant-Associated Protein B;Pulmonary Surfactants;Radiation Injuries;Rattus;Source;Stress;Support System;surfactant;surfactant deficiency;surfactant production;surfactant replacement therapy;Surfactant therapy;System;Technology;Treatment Cost;ventilation;Ventilator-induced lung injury;Viral Pneumonia;Virus Diseases;Wettability

PROJECT_TITLE: Preclinical development of a synthetic lung surfactant dry powder aerosol for hypoxemia or acute respiratory distress syndrome patients receiving different modes of ventilation support


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

ORG_CITY: BOSTON

ORG_DEPT: CHEMISTRY

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

ORG_STATE: MA

PHR: Program Director/Principal Investigator (Last, First, Middle): Reinhard, Bjoern Plasmonic Inactivation of Virus and Mycoplasma Contaminants Relevance to Public Health Microbial contamination is a significant problem in the safe production of biologics as pharmaceuticals, and our goal is to develop nanoplasmonic materials that inactivate viruses and mycoplasma without harming the precious biologics. Biologics, in particular monoclonal antibodies, are among the fastest growing class of pharmaceuticals, and disruption of their production due to viral or mycoplasma contamination has the potential for profound impact on public health. Our approach combines new breakthroughs in the fields of plasmonic metamaterials and nanotechnology to address a vexing and persistent contamination problem in the safe production of monoclonal antibodies and other biologics. OMB No. 0925-0001/0002 (Rev. 08/12 Approved Through 8/31/2015) Page Continuation Format Page

PI_NAMEs: ERRAMILLI, SHYAMSUNDER ;GUMMULURU, SURYARAM ;REINHARD, BJOERN MARKUS (contact)

PROGRAM_OFFICER_NAME: SALVADOR MORALES, CAROLINA

STUDY_SECTION: NANO

STUDY_SECTION_NAME: Nanotechnology Study Section[NANO]


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Nutrition;Obesity;Prevention;Social Determinants of Health;Telehealth

ORG_CITY: COLUMBIA

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

ORG_STATE: SC

PHR: Our proposed project will examine if adding points/gamifying a weight loss intervention produces greater sustained weight loss and social support than the same intervention without points. The goal of the Social POD app is to facilitate social support and weight loss through social gaming with points. This study will test an entirely remotely-delivered behavioral intervention that has the ability to be scaled up so that reach of this treatment approach is broad.

PI_NAMEs: TURNER-MCGRIEVY, GABRIELLE MICHELLE (contact)

PROGRAM_OFFICER_NAME: HALES, CRAIG MAURICE

PROJECT_TERMS: Adherence;Adult;African American;Age;Area;Behavior;behavior change;behavior influence;Behavior Therapy;Behavioral;Body Weight decreased;Chronic Disease;cohort;comparison group;cost effective;Demographic Factors;design;Diabetes Mellitus;Diet;Diet Monitoring;dietary;digital;digital applications;digital intervention;Elements;Empathy;experimental group;Frequencies;Goals;Group Meetings;Health;Health behavior;improved;Intervention;Link;Maintenance;Mediator;mHealth;mobile application;Monitor;Motivation;Non-Insulin-Dependent Diabetes Mellitus;novel;novel strategies;Obesity;Outcome;Overweight;overweight adults;Participant;Pattern;Physical activity;pilot test;Play;podcast;Prevention;Psychosocial Factor;Public Health;Race;Randomized;recruit;remote delivery;Research;Rewards;Risk Factors;Role;Sampling Studies;scale up;sex;social;Social Interaction;Social Network;Social support;Testing;Time;Translating;treatment arm;usability;Weight;weight loss intervention;weight loss program;Work

PROJECT_TITLE: Targeting important behaviors for weight loss through the use of social gaming and points: The Social Pounds Off Digitally (Social POD) study

STUDY_SECTION: LCBH

STUDY_SECTION_NAME: Lifestyle Change and Behavioral Health Study Section[LCBH]


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: SEATTLE

ORG_DEPT: ADMINISTRATION

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: The research that trainees completing the UW Health Services Research Training Program will conduct will further AHRQ's mission to make health care safer, higher quality, affordable, accessible and equitable.

PI_NAMEs: WEINER, BRYAN J. (contact);WILLIAMS, EMILY CATERINA

PROGRAM_OFFICER_NAME: WILLIS, TAMARA

PROJECT_TITLE: University of Washington Health Services Research Training Program


NIH_SPENDING_CATS: Bioengineering;Neurosciences

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE Conventional intracellular electrical signaling tools are not designed for sensing cellular activities either at different positions of a single cell or among different cells in a cellular network, which is essential for deciphering the propagative and communicative behaviors of electrogenic cells' (e.g., neurons) signals and determining the mechanism and treatment of progressive neurological disorders, such as Parkinson's disease. To overcome these challenges, we propose a 3D array of intracellular sensors featuring a field effect transistor configuration that is highly sensitive, accurate, and scalable to record both intra- and inter-cellular electrophysiological events in a cellular network. !

PI_NAMEs: XU, SHENG  (contact)

PROGRAM_OFFICER_NAME: JUSTINOVA, ZUZANA

PROJECT_TERMS: 3-Dimensional;Alzheimer's Disease;Behavior;Biology;Brain;Calcium Channel;Cardiac;Cardiac Myocytes;cell behavior;Cell membrane;Cell Physiology;Cells;clinical practice;Communication;Dedications;design;Diffusion;Disease;electrical potential;Electronics;Electrophysiology (science);Endocrine;Epilepsy;Episodic ataxia;Event;Functional disorder;Glycocalyx;innovation;insight;Ion Channel;Ion Pumps;Ions;Kinetics;Knowledge;Location;Measures;mechanical properties;Motion;Nervous System Disorder;Neurons;Noise;Parkinson Disease;Phospholipids;Physiology;Positioning Attribute;Potassium Channel;Resolution;Sampling;Science;sensor;signal processing;Signal Transduction;Sodium Channel;spatiotemporal;Speed;surface coating;System;technology platform;Testing;Time;Tissues;tool;Transistors;voltage

PROJECT_TITLE: Three-dimensional field effect transistor arrays as a platform technology for intracellular electrophysiology recording.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-N(55)R]


ORG_CITY: ANN ARBOR

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE Cardiovascular diseases (CVD) are still the leading cause of death in the US and worldwide, requiring additional new therapies for CVD prevention and treatment. In this proposal, we will develop genetic deficiency of ApoC3 through CRISPR/Cas9 technology (2020 Nobel Prize in Chemistry) to establish ApoC3 as a novel feasible target for treating hyperlipidemia and CVD.

PI_NAMEs: CHEN, YUQING EUGENE (contact);HAN, RENZHI

PROGRAM_OFFICER_NAME: LIU, LIJUAN

PROJECT_TERMS: Address;adeno-associated viral vector;Animal Model;Animals;Antibodies;apolipoprotein C-III;Aromatase;atherogenesis;Atherosclerosis;Award;base editing;base editor;Cardiovascular Diseases;cardiovascular disorder prevention;cardiovascular disorder risk;cardiovascular disorder therapy;cardiovascular risk factor;Cause of Death;Cells;Chemistry;Cholesterol;Clinical Treatment;Clinical Trials;Combined Modality Therapy;Coronary Arteriosclerosis;coronary event;CRISPR/Cas technology;Dangerousness;density;Dependovirus;Development;Diet;Disease;DNA;DNA Double Strand Break;Drug Targeting;Dyslipidemias;efficacy evaluation;Elements;Engineering;Enzymes;Evaluation;Event;experimental study;Frequencies;gene therapy;Genes;Genetic;Genome;genotoxicity;Germ Cells;Hepatocyte;High Density Lipoproteins;High Fat Diet;Human;hypercholesterolemia;Hyperlipidemia;Hypertriglyceridemia;improved;In Vitro;in vivo;Incidence;infancy;inhibitor;insight;intein;Knock-out;knockout gene;Knowledge;LDLR gene;life span;lipid metabolism;Lipids;Lipoproteins;Mediating;Meta-Analysis;Methods;Modeling;Monitor;mouse model;Mus;Mutation;new therapeutic target;New Zealand;Nobel Prize;novel;novel therapeutics;Oryctolagus cuniculus;Patients;Pharmaceutical Preparations;Pharmacologic Substance;Positioning Attribute;Pre-Clinical Model;Protein Splicing;Proteins;Reporting;Residual state;response;Risk;RNA Interference;Safety;Sagittaria;Study models;Therapeutic;Transcript;translational study;Triglycerides;Tumorigenicity;Variant;Very low density lipoprotein;Work

PROJECT_TITLE: Development of gene editing based therapy for cardiovascular diseases

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-TDPS-R(01)]


ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: Project Narrative Training a new generation of scientific leaders in health services research (HSR) is crucial for improving the quality, efficiency, and equity of health care delivery in the United States. The UC Berkeley-UCSF Health Services Research T32 uses an interdisciplinary social and behavioral science approach to health services research training at both pre- and postdoctoral levels. The faculty group’s application of interdisciplinary advances -- including in data science, behavioral economics, and implementation science methods – to issues of direct relevance to policymakers and health care organization leaders, and close mentorship, equips trainees to conduct partnered health services research that can generate evidence to improve access to care, affordability, quality, patient outcomes, and to advance equity.

PI_NAMEs: RODRIGUEZ, HECTOR P. (contact)

PROGRAM_OFFICER_NAME: DESOTO, MAUSHAMI

PROJECT_TITLE: UC Berkeley-UCSF Health Services Research Training Program


ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE It is estimated that 1 billion people have hypertension worldwide, causing an estimated 9.4 million deaths annually. Short-term studies have shown an improvement in blood pressure associated with self-measured home blood pressure. We will evaluate the effect of home blood pressure monitoring on clinical outcomes, clinic blood pressure, blood pressure medication intensification, and medication adherence.

PI_NAMEs: DRAWZ, PAUL ENGLUND (contact);ISHANI, AREEF

PROGRAM_OFFICER_NAME: REDMOND, NICOLE

PROJECT_TERMS: Acute Renal Failure with Renal Papillary Necrosis;Address;Adherence;Adult;Adverse event;adverse event risk;adverse outcome;Age;American;American Heart Association;Anti-Hypertensive Agents;Blood Pressure;blood pressure medication;blood pressure reduction;Cardiology;Cardiovascular system;Caring;Case Management;Case Manager;Cessation of life;Characteristics;Chronic Disease;Clinic;Clinical;clinical practice;clinical risk;Clinical Trials;cohort;college;comorbidity;Country;Data;design;Diagnosis;Disease Management;Effectiveness;effectiveness evaluation;Electrolytes;Enrollment;Ethnic Origin;Evaluation Studies;Event;Goals;Guidelines;health data;Home;Home Blood Pressure Monitoring;Hypertension;hypertension control;implementation strategy;improved;Individual;Knowledge;Link;Measurement;Measures;medication compliance;Methods;Morbidity - disease rate;mortality;Nephrology;Observational Study;Outcome;participant enrollment;Patient Selection;Patients;Persons;Pharmaceutical Preparations;Population Heterogeneity;programs;Provider;Race;Randomized, Controlled Trials;Recommendation;Reporting;Risk;Risk Factors;Risk Reduction;routine practice;sex;Site;Socioeconomic Status;Subgroup;telehealth;Time;transmission process;United States Preventative Services Task Force;Variant;Veterans

PROJECT_TITLE: Home Blood Pressure Outcomes Evaluation Study (HOMESTEAD)

STUDY_SECTION: CMGC

STUDY_SECTION_NAME: Clinical Management in General Care Settings Study Section[CMGC]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Genetics;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: NEW HAVEN

ORG_DEPT: PATHOLOGY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: This proposal will use a multidisciplinary approach to elucidate neuron-specific mechanisms that underlie increased risk for amyotrophic lateral sclerosis (ALS) and frontotemporal dementia –motor neuron disease (FTD-MND) in patients with Ataxin-2 intermediate-length polyglutamine expansions. Results from these analyses will provide new insights into (1) the molecular basis of Ataxin-2 / TDP-43 interactions, (2) how Ataxin-2 polyQ expansions interact with TDP-43 at the cellular level to impact post-transcriptional RNA regulation, and (3) potential molecular targets for mechanism-based therapies.

PI_NAMEs: GOPAL, PALLAVI P. (contact)

PROGRAM_OFFICER_NAME: GUBITZ, AMELIE

PROJECT_TERMS: Affinity;ALS patients;Amyotrophic Lateral Sclerosis;amyotrophic lateral sclerosis therapy;Animal Model;anterograde transport;Axon;Axonal Transport;Binding;Biological Assay;biophysical properties;Cellular Assay;Clinical;crosslink;Cytoplasm;Cytoplasmic Granules;Cytoskeleton;Data;dementia risk;Dendrites;design;Disease;disorder risk;Distal;DNA Binding;DNA-Binding Proteins;Doctor of Philosophy;Exhibits;familial amyotrophic lateral sclerosis;Fluorescence Recovery After Photobleaching;Fluorescence Resonance Energy Transfer;Frontotemporal Dementia;frontotemporal lobar dementia amyotrophic lateral sclerosis;Genetic;Glutamine;Goals;Human;imaging approach;Immunofluorescence Immunologic;Immunoprecipitation;in vivo;induced pluripotent stem cell;insight;interdisciplinary approach;knock-down;Knock-in Mouse;Knock-out;Knowledge;Label;Length;Life;Link;live cell imaging;Maintenance;Measures;Messenger RNA;Molecular;molecular dynamics;molecular modeling;Molecular Target;Motor Neuron Disease;Motor Neurons;mRNA Stability;mRNA Translation;Mus;mutant;Mutation;Nerve Degeneration;Neurodegenerative Disorders;neuron component;Neurons;Nuclear;Oligonucleotides;Pathogenesis;Pathogenicity;Pathologic;Pathology;Patients;Photobleaching;polyglutamine;Post-Transcriptional Regulation;Post-Transcriptional RNA Processing;posttranscriptional;Property;protein TDP-43;Proteins;Publishing;Puromycin;Regulation;Research;response;Ribonucleoproteins;Risk;RNA;RNA Binding;RNA metabolism;RNA Recognition Motif;RNA Splicing;RNA Stability;RNA-Binding Proteins;Role;SCA2 protein;scaffold;single molecule;single-molecule FRET;small molecule;small molecule inhibitor;Solubility;spatiotemporal;sporadic amyotrophic lateral sclerosis;Techniques;Testing;Toxic effect;Transcript;transcriptome;transcriptome sequencing;transcriptomics;translation assay;Translations;Work

PROJECT_TITLE: Role of Ataxin-2 polyglutamine expansion on TDP-43 transport and post-transcriptional RNA regulation in neurons

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Emerging Infectious Diseases;Infectious Diseases;Rare Diseases;Tuberculosis

ORG_CITY: SAN ANTONIO

ORG_NAME: UNIVERSITY OF TEXAS SAN ANTONIO

ORG_STATE: TX

PHR: Narrative This project will study the structure‐and‐function relationships of a recently identified protein in Streptococcus pyogenes that we propose has a role in iron uptake. The outcome of this study will help in the identification of new therapeutic targets towards Group A Streptococcus.

PI_NAMEs: TRAORE, EPHRAHIME  (contact)

PROGRAM_OFFICER_NAME: STAMM, JOYCE CHIN-CHIN NG

PROJECT_TERMS: Active Sites;Affinity;analog;Bilirubin;Biliverdin reductase;Biliverdine;Binding;Binding Proteins;Biochemical;Biological Assay;Biological Process;cofactor;combat;Copper;Coupled;Crystallography;Disease;Electron Spin Resonance Spectroscopy;Enzymatic Biochemistry;Enzymes;experimental study;Flavin Mononucleotide;Flavins;Foundations;Goals;Heme;heme a;his6 tag;Histidine;human pathogen;Immune response;Infection;innovation;Iron;Kinetics;Length;Ligands;Mediating;Mediator;Metals;Molecular;Mycobacterium tuberculosis;NADP;new therapeutic target;novel;Operon;Outcome;Outcome Study;oxidation;Oxidoreductase;Oxygenases;pathogen;Pathogenesis;Pathway interactions;Periplasmic Proteins;Porphyrins;prevent;Proteins;Publishing;Reaction;Recycling;Reducing Agents;Resolution;Role;Streptococcus;Streptococcus pyogenes;Structure;Structure-Activity Relationship;System;therapeutic target;uptake;Work

PROJECT_TITLE: Structure-Function Relationship study of HupZ


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Pediatric Cancer;Rare Diseases;Social Determinants of Health

ORG_DEPT: OTHER HEALTH PROFESSIONS

PHR: PROJECT NARRATIVE Adolescents and young adults with cancer experience multiple distressing symptoms during treatment, yet few age-appropriate resources have been developed to help these individuals self-manage their symptoms. This project will test an intervention designed to improve symptom self-management by helping adolescents and young adults understand their unique symptom experience and discuss it with their health care providers. Enabling patients to have a more active role in self-management during cancer treatment should lessen their symptom severity and distress during cancer treatment.

PI_NAMEs: ELSWICK, RONALD K (contact)

PROGRAM_OFFICER_NAME: UMAR, ASAD

PROJECT_TERMS: acceptability and feasibility;active method;Address;Adolescent and Young Adult;Adolescent and young adult cancer patients;Affect;Age;Asthma;Awareness;Behavior;cancer diagnosis;cancer therapy;chemotherapy;Chronic Disease;Clinical;clinical care;Collaborations;common symptom;Communication;comparative efficacy;computerized;Conscious;contextual factors;coping;cost;Data;Decision Making;design;Diabetes Mellitus;Diagnosis;Disease;Distress;Economics;Education;effective intervention;Electronic Health Record;experience;Fatigue;follow-up;Gender;Goals;group intervention;health care quality;Health Personnel;heuristics;Image;improved;Individual;Informal Social Control;innovation;insight;Intervention;Malignant Neoplasms;Modeling;Nausea;Outcome;Outcome Study;Outcomes Research;Patients;person centered;pilot test;Population;post intervention;primary outcome;Problem Solving;Process;provider communication;Psyche structure;Quality of life;Race;Randomized;Randomized, Controlled Trials;reduce symptoms;Research;Research Priority;Resources;Role;satisfaction;secondary outcome;Self Efficacy;Self Management;Self Perception;Severities;Site;skills;Social Functioning;social health determinants;Social isolation;symptom management;symptom self management;symptomatic improvement;Symptoms;Tablet Computer;Testing;therapy design;Time;tool;treatment as usual;trial design;Unconscious State;Underserved Population;United States;usual care arm;Visit;Visualization;Work

PROJECT_TITLE: A Randomized Controlled Trial using a Heuristic Tool To Improve Symptom Self-Management in Adolescents and Young Adults with Cancer

STUDY_SECTION: ICSC

STUDY_SECTION_NAME: Interdisciplinary Clinical Care in Specialty Care Settings Study Section[ICSC]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Biotechnology;Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Genetics;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: CLEVELAND

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: Narrative CHCHD10, a gene coding for a mitochondrial protein, is the second most frequently mutated gene in Frontotemporal Lobar Degeneration (FTLD)-Amyotrophic Lateral Sclerosis (ALS) spectrum disorders. However, as only 1 patient with CHCHD10 mutation (ALS-linked CHCHD10R15L) and no FTD patient with CHCHD10 mutation has come to autopsy, we do not know the pathological signatures of CHCHD10-driven pathogenesis and to what extent such signatures are present in sporadic Alzheimer’s disease and related dementias (ADRDs). This proposal will allow us to identify and validate the changes in insoluble proteome driven by CHCHD10 function and dysfunction and test the hypothesis that such pathological signatures results from disruption of mitochondrial proteostasis and autophagic clearance of proteotoxically challenged mitochondria, and that restoration of wild type CHCHD10 represents a viable strategy to mitigate proteotoxic burden and disease outcomes.

PI_NAMEs: KANG, DAVID E (contact)

PROGRAM_OFFICER_NAME: SHEWMAKER, FRANK PAUL

PROJECT_TERMS: ALS patients;Alzheimer's Disease;Alzheimer's disease related dementia;Amyotrophic Lateral Sclerosis;Autopsy;Behavioral;Biochemical;Biological Assay;Brain;Cells;Chinese population;Clinical;Code;Cognitive;comorbidity;Disease;Disease Outcome;Electrophysiology (science);European;Exhibits;Failure;Frontotemporal Dementia;Frontotemporal Lobar Degenerations;frontotemporal lobar dementia amyotrophic lateral sclerosis;Functional disorder;Genes;Hippocampus;Human;Impairment;in vivo;Link;misfolded protein;Mitochondria;mitochondrial dysfunction;Mitochondrial Proteins;Modeling;Molecular;Motor;Motor Neurons;mouse model;Mus;mutant;Mutate;Mutation;neuroinflammation;Neurons;neuropathology;novel;Outcome;Pathogenesis;Pathologic;Pathology;Pathway interactions;Patients;Phenotype;Physiology;Prevalence;promoter;Proteasome Inhibition;protein TDP-43;Proteins;Proteome;Proteomics;proteostasis;proteotoxicity;PrP;Reporter;response;restoration;Role;sciatic nerve;Slice;Stress;Synapses;Synaptic plasticity;tau Proteins;Testing;Tissues;Transfection;Transgenic Mice;Transgenic Organisms;Western Blotting

PROJECT_TITLE: Pathological signatures of CHCHD10 dysfunction in ADRDs


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Mental Health

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: Project narrative Psychiatric epidemiology, a core science of public mental health, is critical to development of prevention, intervention, and translation efforts to improve population mental health. For 50 years, the Psychiatric Epidemiology Training (PET) program at Columbia University has advanced scholarship, science, and training in psychiatric epidemiology. Through balanced growth of historical legacies and new intellectual resources, we will continue to grow this highly successful program, one of only a few of its kind in the US, to prepare the next generation of scholars and change-makers to address critical challenges among those with mental illness across the globe.

PI_NAMEs: KEYES, KATHERINE M. (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: Psychiatric epidemiology;Research Training;Training Programs

PROJECT_TITLE: Research Training Program in Psychiatric Epidemiology


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging

ORG_CITY: BALTIMORE

ORG_DEPT: NEUROLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: This is a training program pertaining to age-related cognitive disorders. The growing number of older persons who suffer from these conditions requires training young researchers in state-of-the-art approaches to these disorders, with a focus on integration and communication across disciplines.

PI_NAMEs: ALBERT, MARILYN S. (contact)

PROGRAM_OFFICER_NAME: WAGSTER, MOLLY V

PROJECT_TERMS: age related cognitive disorder;Research Training

PROJECT_TITLE: Research Training in Age-Related Cognitive Disorders


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Services;Maternal Health;Mental Health;Nutrition;Obesity;Pediatric;Physical Activity;Prevention;Primary Health Care;Social Determinants of Health;Women's Health Research

ORG_CITY: UNIVERSITY PARK

ORG_DEPT: MISCELLANEOUS

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

ORG_STATE: PA

PHR: PROJECT NARRATIVE  The proposed study will test the efficacy of a family-focused preventive intervention in improving healthy lifestyles among first-time parents in military families and reducing obesity risk among their infants. We propose to test this innovative approach in the context of the Military Health System (MHS), within a research network of military family medicine physicians, for several reasons. Recruitment will be conducted by embedded clinical staff from the network in the primary care clinics, and follow-up will be facilitated by the tracking providing by the MHS.

PI_NAMEs: FEINBERG, MARK ETHAN (contact)

PROGRAM_OFFICER_NAME: OSGANIAN, VOULA

PROJECT_TERMS: active duty;Address;Adolescent;Adult;base;Behavior;Biological Markers;Birth;Birth Weight;Characteristics;Child;Child Rearing;Childhood;Clinic;Clinical;Conflict (Psychology);coping;cost;cost effective;Couples;Data;Data Collection;Decision Making;Development;Discipline of obstetrics;economic impact;efficacy evaluation;efficacy testing;Electronic Health Record;ethnic diversity;evidence base;experience;Extended Family;Family;Family health status;Family member;Family Practice;Family Relationship;Family Violence;Fathers;feeding;Financial Hardship;Florida;follow-up;Fostering;Foundations;Future;Goals;Health;Health behavior change;Health Promotion;Healthcare;healthy lifestyle;high risk;Home visitation;Hospitals;improved;Infant;infant adiposity;Inflammatory;Informal Social Control;Infrastructure;innovation;insight;intergenerational;Intervention;intervention delivery;Intervention Studies;Interview;Length;Life Style;maternal depression;maternal stress;Mediation;Medical Records;member;Mental Health;military family;military health system;Military Personnel;Modality;Modeling;Mothers;Motivation;Nevada;Nurses;nutrition;Obesity;obesity prevention;obesity risk;online version;Outcome;Overweight;overweight child;Parents;Participant;Pathway interactions;patient engagement;Perinatal;perinatal period;Physical activity;Physicians;Population;Population Heterogeneity;Postpartum Period;postpartum weight;Pregnancy;Premature Birth;Prevention program;preventive intervention;primary care clinic;primary outcome;Problem behavior;programs;psychosocial;racial diversity;Randomized;randomized trial;rapid infant weight gain;Recommendation;recruit;Regulation;Research;Sampling;Schools;secondary outcome;Series;service member;Siblings;skills;Sleep;Stress;stressor;success;Testing;Time;transmission process;tv watching;Weight;Work

PROJECT_TITLE: Adaptation of an Evidence-based Family Program for Obesity Prevention in Health Care Context: Testing Outcomes and Mechanisms with First-time Military Parents and their Infants

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


PHR: Project Narrative This training program is designed to develop early career scholars who identify timely research problems, conceptualize creative responses, apply cutting-edge research techniques, and effectively guide the translation of findings into policy and practice. Our trainees are prepared to tackle the complex ways in which contemporary health and health care problems transcend disciplinary boundaries. Their published work, both during and after completing the program, has had a demonstrable impact on health care, healthcare equity, as well as the policies and practices that affect both.

PI_NAMEs: SCHLESINGER, MARK J (contact)

PROJECT_TITLE: Yale Training Program in Health Services Research


ADMINISTERING_IC: HD

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Disability Research;Emerging Infectious Diseases;Infectious Diseases;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric;Prevention

ORG_CITY: EUGENE

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF OREGON

ORG_STATE: OR

PHR: 8. Project Narrative This application proposes a longitudinal study of the long-term impact of COVID-19 pandemic-related school closures on the growth of emotional and behavioral problems in a diverse sample of 613 children, ages 4–15 years, with and without developmental disabilities and their families. The COVID-19 pandemic has exacerbated the risk of increased emotional and behavioral problems, parenting stress, and poor school outcomes for high-risk children and families, including those with disabilities. This study will significantly contribute to our understanding of long-term effects of pandemic-related school closures and elucidate policy and intervention recommendations for supporting children with disabilities and their families in a post-pandemic world.

PI_NAMEs: DEGARMO, DAVID S.;MCINTYRE, LAURA LEE  (contact);NEECE, CAMERON LEIGH

PROGRAM_OFFICER_NAME: MILLER, BRETT

PROJECT_TERMS: Adult;Affect;Age;Automobile Driving;Behavioral;Buffers;California;Caregivers;Child;Child Development;Child Rearing;Child Support;Clinical;clinically significant;cohort;Cohort Studies;Collaborations;COVID-19;COVID-19 impact;COVID-19 pandemic;COVID-19 stress;Data;data harmonization;data modeling;Data Pooling;Development;Developmental Delay Disorders;Developmental Disabilities;Disabilities experience;disability;disability risk;Disabled Children;Economics;Education;Educational Intervention;Emotional;Employment;Enrollment;ethnic minority;Ethnic Origin;Exhibits;experience;experimental study;falls;Family;Funding;Geography;Growth;high risk;Home;improved;Individual;Intervention;Intervention Trial;long term COVID-19 pandemic impacts;Long-Term Effects;Longitudinal Studies;longitudinal, prospective study;Mental Health;Modeling;Nursery Schools;Oregon;Outcome;pandemic disease;pandemic impact;pandemic stress;parenting intervention;Parents;Phase;Policies;post-pandemic;Prevention trial;Problem behavior;prospective;Prospective Studies;Psychopathology;Public Health;Race;racial minority;randomized, controlled study;Randomized, Controlled Trials;rate of change;Recommendation;Recovery;recruit;Reporting;Research;Research Personnel;Risk;Sampling;school closure;School-Age Population;Schools;Services;Social isolation;Stress;stress management;teacher;Testing;Time;Transact;underserved minority;Youth

PROJECT_TITLE: Investigating the impacts of COVID-19 school closures on long-term adjustment in youth with or at risk for disability


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;Genetics;Infectious Diseases;Malaria;Orphan Drug;Prevention;Rare Diseases;Vector-Borne Diseases

ORG_CITY: IRVINE

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: Project Narrative Further progress in the malaria eradication agenda requires novel vector control strategies to complement advances in prophylactic and therapeutic drug discovery and an effective vaccine. Long-term, sustainable impacts on the vector mosquitoes requires the deployment of strategies designed to be resilient to the immigration of susceptible mosquitoes and parasite-infected people. Approaches that couple genes that confer resistance to parasite transmission with mechanisms for spreading those genes through target mosquito populations hold great promise for contributing to the control of this major disease.

PI_NAMEs: DIMOPOULOS, GEORGE ;JAMES, ANTHONY A. (contact)

PROGRAM_OFFICER_NAME: COSTERO-SAINT DENIS, ADRIANA

PROJECT_TERMS: Accounting;Address;Africa;Africa South of the Sahara;Alleles;Anopheles gambiae;Area;Automobile Driving;Biology;Cessation of life;Cities;Clustered Regularly Interspaced Short Palindromic Repeats;Communities;Complement;cost effective;Country;CRISPR/Cas technology;Culicidae;Deceleration;design;Development;Disease;disorder control;DNA;drug discovery;Ecology;endonuclease;Engineering;Environment;Event;Future;Gene Dosage;gene drive system;Generations;Genes;Genetic;genetic approach;genetic element;Genetic Engineering;Genetic Load;Genetic Recombination;Genetic Structures;Genome;Germ Lines;Goals;Guide RNA;Immigration;indexing;Infection;innovation;Insecta;Knowledge;Laboratories;Maintenance;Malaria;malaria transmission;Measurable;Measures;Modeling;Modification;Molecular;Molecular Genetics;Morbidity - disease rate;mortality;novel;novel therapeutics;Parasite resistance;Parasites;Partner in relationship;Performance;Persons;Population;population migration;Predisposition;Prevalence;prevent;programs;Property;prophylactic;Refractory;repaired;reproductive fitness;reproductive success;Research;resilience;Resistance;Science;Site;Source;Southern Asia;Structure;success;System;Technology;Testing;Therapeutic;Time;tool;Transgenes;Transgenic Organisms;transmission blocking;transmission process;Vaccines;vector;vector control;vector mosquito;Work;World Health Organization

PROJECT_TITLE: Impact of gene-drive systems for population modification on malaria vector mosquitoes

STUDY_SECTION: VB

STUDY_SECTION_NAME: Vector Biology Study Section[VB]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Genetics;Human Genome;Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases

ORG_DEPT: OPHTHALMOLOGY

PHR: Project narrative High intraocular pressure is a key risk factor for glaucoma. This application will define and critically test key molecular events that control intraocular pressure in a mutant human glaucoma gene. Understanding these molecular processes will ultimately lead to a rational design of new treatment strategies to prevent glaucoma.

PI_NAMEs: JOHN, SIMON W (contact)

PROGRAM_OFFICER_NAME: SONG, HONGMAN

PROJECT_TERMS: Address;Advanced Development;Affect;Age;Aging;Alleles;Anterior segment dysgenesis;Aqueous Humor;Binding Proteins;Biological Assay;Cell Physiology;cell type;Cells;cellular resilience;ChIP-seq;Cicatrix;Clustered Regularly Interspaced Short Palindromic Repeats;Co-Immunoprecipitations;Collection;Communities;Data;Defect;Development;dietary;Disease;DNA Binding;dominant genetic mutation;Dominant-Negative Mutation;Drainage procedure;early onset;Energy Metabolism;Ethylnitrosourea;Event;experimental study;extracellular;Genes;Genetic Transcription;genome-wide analysis;Glaucoma;Goals;Health;high intraocular pressure;homeodomain;Human;Individual;Induced Mutation;Inherited;Learning;LIM Domain;limbal;Metabolic;Metabolism;Methods;Mitochondria;mitochondrial dysfunction;mitochondrial metabolism;Modeling;Molecular;Morphology;Mus;Mutagenesis;mutant;Mutant Strains Mice;Mutation;Nail-Patella Syndrome;Nature;Niacinamide;novel;novel therapeutic intervention;Open-Angle Glaucoma;Operative Surgical Procedures;Oral Administration;Oxidative Stress;Pathway interactions;Patients;Persons;Pharmaceutical Preparations;Phenotype;Physiologic Intraocular Pressure;Physiological;Positioning Attribute;Predisposition;prevent;Primary Open Angle Glaucoma;Process;protein function;protein protein interaction;Protein Truncation;Proteins;rational design;resilience;Resistance;Risk Factors;Role;Severity of illness;single cell sequencing;Specificity;Stress;Structure;Structure of sinus venosus of sclera;Testing;Time;time interval;Tissues;tool;Trabecular meshwork structure;transcription factor;Transcriptional Regulation;transcriptome;transcriptomics;Variant;Work

PROJECT_TITLE: Models, mechanisms and treatment of LMX1B-induced glaucoma


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

ORG_CITY: PORTLAND

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

PHR: Narrative In normal hearing the understanding of speech depends upon the ability of the organ of Corti to properly process the information content of sound. In the context of this proposal, the processing requires the correct system components (e.g., fluid hydrodynamics) as well as the biochemical components the control the elusive mechanical/physiological character of the tectorial membrane. Among the components, two are chosen for study in this proposal. The effect of perilymph viscosity and tectorial membrane calcium buffering. These have not yet been investigated and the resulting new information can lead to insights into hearing loss treatment strategies.

PI_NAMEs: FRIDBERGER, ANDERS ;NUTTALL, ALFRED L (contact)

PROGRAM_OFFICER_NAME: CYR, JANET

PROJECT_TERMS: Address;Age;Animals;Apical;Auditory;Auditory Physiology;Basilar Membrane;Bass;Binding Sites;Biochemical;Biological Models;Blood flow;Buffers;Calcium;Calcium ion;Cell Physiology;Cells;Charge;Chemicals;Chronic;Clinical;Cochlea;Cochlear Implants;confocal imaging;correctional system;Data;design;Development;deviant;Endolymph;Environment;experimental study;Extracellular Fluid;Frequencies;Functional disorder;Furosemide;Future;Goals;Hair Cells;Hearing;hearing impairment;hearing loss treatment;helicotrema;High-Frequency Hearing Loss;Human;imaging modality;In Vitro;in vivo;innovation;insight;interest;Intervention;Knowledge;Laboratories;Labyrinth;Link;Liquid substance;Location;Measurement;Measures;Mechanics;Methods;minimally invasive;Modeling;Modiolus;Molecular;Motion;mutant;Mutant Strains Mice;Nature;Neurosciences;normal hearing;novel;Optical Coherence Tomography;Organ;Organ of Corti;Output;Pathology;Perfusion;Perilymph;pharmacologic;Physiological;Physiology;Presbycusis;pressure;Process;Property;Proteins;Pump;Regulation;Research;response;Rest;Role;Sensory;Site;sound;sound frequency;Speech;stem;Stimulus;Stria Vascularis;Structural Protein;Structure;System;Techniques;tectorial membrane;theories;Time;Tissues;Travel;treatment strategy;vibration;Viscosity;Wood material;Work

PROJECT_TITLE: The mechanical and ionic roles of cochlear fluids in hearing and hearing loss


NIH_SPENDING_CATS: Lung;Pulmonary Fibrosis

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Narrative: There are currently few to no effective therapies to treat pulmonary fibrosis, which is a devastating progressive illness. The multifunctional cytokine transforming growth factor-b (TGF-b) is at the apex of a series of pathologic inflammatory and fibrotic events that culminate in fibroinflammatory pathology. The far-reaching goals of this project are to improve mechanistic understanding so that TGF-b can be effectively and selectively targeted to treat fibrosing and chronic inflammatory lung disease.

PI_NAMEs: CHENG, YIFAN ;NISHIMURA, STEPHEN L (contact)

PROGRAM_OFFICER_NAME: VUGA, LOUIS J

PROJECT_TERMS: Address;Apical;Binding;Binding Proteins;Biological;Biological Assay;Cell surface;Cells;chronic inflammatory lung disease;Clinical;Complex;conformational conversion;Cryoelectron Microscopy;Crystallography;cytokine;Data;design;Development;Diffuse;Diffusion;effective therapy;Event;Extracellular Matrix;Fibrosis;Gene Deletion;Goals;Head;Homeostasis;Human;idiopathic pulmonary fibrosis;Immune;improved;in vivo;Inflammatory;insight;Integrins;latent TGF-beta binding protein;Length;Ligand Binding;LRRC32 gene;Lung Diseases;Mediating;Mediator;Medical;Membrane;Methods;Modeling;Molecular Conformation;Monoclonal Antibodies;particle;Pathologic;Pathology;Peptides;Pharmaceutical Preparations;Phase II Clinical Trials;Physiological;Play;Pre-Clinical Model;Primates;Property;protein complex;Proteins;Pulmonary Fibrosis;receptor;Regulation;Research;Resolution;Risk;Rodent;Role;Safety;Series;Signal Induction;Signal Transduction;Structure;Techniques;Testing;Therapeutic;therapeutic target;therapy development;Toxic effect;Transforming Growth Factor beta;Transforming Growth Factor beta Receptors;Transforming Growth Factors;Visualization

PROJECT_TITLE: Conformational regulation of TGF-β activation by integrin αvβ6

STUDY_SECTION: MSFC

STUDY_SECTION_NAME: Macromolecular Structure and Function C Study Section[MSFC]


ED_INST_TYPE: OTHER SPECIALIZED SCHOOLS

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Narrative The world's aging societies require solutions for debilitating and costly chronic diseases that rob people of the joy of their `golden years,' and threaten to overwhelm both the capacity of the medical establishment and the treasuries of national governments. Ultimately, the solutions to these problems will lie in preventative measures or actual cures for diseases such as Alzheimer disease, Parkinson disease, coronary artery disease, diabetes, late onset cancers, rheumatoid and arthritic diseases, stroke, respiratory diseases, and susceptibility to infectious bacteria and viruses (e.g. COVID-19). This Geroscience program in the Biology of Aging prepares researchers to discover the mechanistic complexities and causes of aging and of age-related diseases, and to design rational preventative measures or cures for clinical testing.

PI_NAMEs: CURRAN, SEAN P (contact)

PROGRAM_OFFICER_NAME: CARTER, CHRISTY

PROJECT_TERMS: Biology of Aging;Geroscience;Training

PROJECT_TITLE: USC-Buck Geroscience Training in the Biology of Aging


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Organ Transplantation;Pediatric;Pneumonia and Influenza;Prevention;Transplantation;Vaccine Related

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

PHR: NARRATIVE Influenza virus is a significant pathogen in pediatric solid organ transplant (SOT) recipients, but these individuals respond poorly to standard-dose (SD) inactivated influenza vaccine (IIV). Studies suggest that two doses of SD-IIV or one dose of high-dose (HD-IIV) is superior to one dose of SD-IIV; however, this has not been tested in the highest risk early post-transplantation period, and pediatric-specific studies of these regimens and their impact are critically lacking. This study aims to compare two doses of HD-IIV to two doses of SD-IIV administered in the same influenza season in pediatric kidney, heart, and/or liver SOT recipients in the early post-transplant period.

PI_NAMEs: DANZIGER-ISAKOV, LARA A;HALASA, NATASHA BASSAM (contact)

PROGRAM_OFFICER_NAME: HAYES, DEBORAH

PROJECT_TERMS: Ache;Acute;Address;Adult;Adverse event;Antibodies;Antibody titer measurement;Antigens;B-Lymphocyte Subsets;B-Lymphocytes;Biological Assay;Biopsy;CD4 Positive T Lymphocytes;Cellular Assay;Child;Childhood;Clinical;Cytometry;Data;design;Development;Dose;Double-Blind Method;Enrollment;Evaluation;exhaustion;Fatigue;Fever;Frequencies;Headache;Heart;Hemagglutination;high risk;HLA Antigens;Hospitalization;immune activation;Immune response;immunogenic;immunogenicity;Immunologics;Immunophenotyping;immunosenescence;Impairment;Individual;Induration;Influenza;Influenza A virus;Influenza B Virus;influenza infection;Influenza vaccination;influenza virus vaccine;influenzavirus;Injections;Kidney;Knowledge;Liver;Malaise;Measures;Myalgia;Nausea;organ transplant recipient;Organ Transplantation;Pain;pathogen;Phase;phase 1 study;phase II trial;Phenotype;Population;post-transplant;Prevention strategy;primary endpoint;Primary Prevention;Randomized;Reaction;Recommendation;Recording of previous events;Redness;Regimen;response;Safety;Sample Size;seasonal influenza;Seasons;senescence;Serum;Severities;Site;Solid;standard measure;Swelling;T-Cell Activation;T-Lymphocyte;Testing;trial comparing;Vaccination;vaccination strategy;Vaccine Antigen;vaccine immunogenicity;vaccine strategy;vaccine trial;Vaccines;Vomiting

PROJECT_TITLE: Comparison of High vs. Standard Dose Influenza Vaccine in Pediatric Solid Organ Transplant Recipients


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Emerging Infectious Diseases;Genetics;Human Genome;Infectious Diseases

ORG_DEPT: BIOCHEMISTRY

PHR: Project Narrative: We have recently shown that several aspects of the structures of bacterial chromosomes play important roles in gene regulation, especially of genes involved in nutrient acquisition and virulence. We will utilize a recently developed suite of tools to determine the contributions of chromosomal structure to the regulation of these processes across a broad range of bacterial species and physiological conditions. Our findings will assist in the design of targeted therapeutics inhibiting bacterial virulence, and enhance our capabilities in designing regulatory circuits for synthetic biology.

PI_NAMEs: FREDDOLINO, LYDIA PETRA (contact)

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TERMS: 3-Dimensional;Architecture;Area;Automobile Driving;Bacteria;Bacterial Antibiotic Resistance;Bacterial Chromosomes;Bacterial Genes;bacterial genetics;Bacteriophage mu;Behavior;Binding;ChIP-seq;Chromosome Structures;clinically relevant;crosslink;design;Dissociation;DNA;DNA-Binding Proteins;DNA-Protein Interaction;Epigenetic Process;Escherichia coli;experimental study;Gene Expression Regulation;Genes;Genetic;Genetic Transcription;Genome;genome-wide;genomic profiling;global health;Growth;Heterochromatin;Impairment;innovation;innovative technologies;interest;Investigation;Laboratories;Logic;Maps;Measurement;Metabolic;Methods;Modification;Molecular;Motility;Nutrient;Organism;Physiological;Play;Post-Translational Protein Processing;prevent;Process;Prophages;protein profiling;Proteins;rapid technique;Regulation;Research;response;Role;Sigma Factor;Structure;Study models;synthetic biology;targeted treatment;Technology;Therapeutic;three dimensional structure;tool;transcription factor;transcription regulatory network;Transcriptional Regulation;Virulence;virulence gene;Work

PROJECT_TITLE: Building a unified framework for understanding bacterial gene regulation and chromosomal architecture

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MGG-C(55)R]


ORG_CITY: JACKSON

ORG_NAME: UNIVERSITY OF MISSISSIPPI MED CTR

ORG_STATE: MS

PHR: Project Narrative We seek to understand the basis for increased susceptibility of the elderly heart to surgical stress insult via investigating signaling mechanisms underlying altered adaptive responses to cardiovascular stress with aging. The study explores whether a pharmacological approach targeting a novel signaling pathway in addition to physical activity could improve the adaptive signaling mechanisms in the elderly heart, the findings from the study could lead to novel therapeutic strategies aimed at limiting cardiovascular damage in elderly.

PI_NAMEs: LI, JI  (contact)

PROGRAM_OFFICER_NAME: SHI, YANG

PROJECT_TERMS: 5'-AMP-activated protein kinase;Acute;age related;Age Years;age-related disease;aged;Aging;aging related;Agonist;Alleles;Anterior;Anterior Descending Coronary Artery;Atherosclerosis;atherothrombosis;Binding;Blood Vessels;Cardiac;Cardiac Myocytes;Cardiac Surgery procedures;Cardiovascular system;CD44 gene;Cell Respiration;Cells;Cellular Stress;Clinical Research;Complex;coping;coronary angioplasty;Coronary artery;cytokine;Elderly;Embryo;ex vivo perfusion;Exercise;exercise training;Fibroblasts;Genotype;Goals;Heart;heart damage;Human;Impairment;improved;in vivo;Incidence;Inflammation;Inflammatory Response;Injury;Integral Membrane Protein;Intervention;Knockout Mice;Laboratories;Left;Leukocytes;life span;Ligation;Link;Migration Inhibitory Factor;Molecular;mortality;Mus;Nonpharmacologic Therapy;novel;novel strategies;novel therapeutic intervention;old mice;older patient;Older Population;Operative Surgical Procedures;Outcome;Oxidative Stress;Oxidative Stress Induction;Pathway interactions;Performance;pharmacologic;Phenols;Physical activity;Physiological;population based;Predisposition;prevent;Prevention;Protocols documentation;Reactive Oxygen Species;receptor;Regulation;Reporting;Resistance;response;restoration;Role;Sepsis;Shock;Signal Pathway;Signal Transduction;small molecule;Source;Stress;Surgical Injuries;Surgical Shock;System;Testing;Vascular Diseases;vascular inflammation;vascular injury;Vascular System;Work

PROJECT_TITLE: MIF and Cardiovascular Inflammation

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Drug Abuse (NIDA only);Fentanyl Misuse and Addiction;Harm Reduction for Substance Misuse;Neurosciences;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: LEXINGTON

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: PROJECT NARRATIVE  Prescription and illicit opioid use have been recognized as a public health crisis, and heroin is being rapidly replaced with illicitly-manufactured fentanyl. Xylazine, a veterinary anesthetic, is being used as an adulterant in fentanyl use, and this pattern of polysubstance use renders naloxone ineffective at precipitating withdrawal and thus reversing overdose. The proposed research has the potential to not only uncover novel neurobehavioral mechanisms by which xylazine and fentanyl polysubstance use uniquely alter the reward pathway, behavior, and render naloxone unable to precipitate withdrawal, but will also identify and target mechanisms to reverse these effects.

PI_NAMEs: GIPSON-REICHARDT, CASSANDRA D (contact);HINDS, TERRY D

PROGRAM_OFFICER_NAME: VEMURI, KIRAN R V

PROJECT_TERMS: Accidents;Adrenergic Agents;Affect;Agonist;Anesthetics;Behavior;behavioral phenotyping;Biological Assay;Brain;Clinical;Consumption;CSF1R gene;Data;Disinhibition;Dopamine;Dose;Drug Combinations;Drug usage;EGF gene;Epidermal Growth Factor Receptor;Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor;Event;FDA approved;Fentanyl;fentanyl overdose;fentanyl self-administration;fentanyl use;Future;genetic manipulation;Heroin;high risk;high risk population;Hyperactivity;illicit opioid;Impact evaluation;improved;Individual;lofexidine;manufacture;Maps;Measures;Morphine;Naloxone;neural;neural circuit;neurobehavioral;Neurobiology;neuromechanism;novel;Nucleus Accumbens;Opioid;opioid overdose;Opioid Receptor;opioid use;opioid withdrawal;overdose death;Overdose reversal;Pathway interactions;Pattern;Pharmaceutical Preparations;pharmacologic;Phenotype;Phosphotransferases;polysubstance use;Precipitation;prescription opioid;prevent;Public Health;Rattus;receptor;Reporting;Research;Resistance;response;Rewards;Sampling;Self Administration;Signal Pathway;Signal Transduction;Technology;Testing;Therapeutic;therapeutic target;treatment strategy;Urine;Ventral Tegmental Area;Western Blotting;Withdrawal;Xylazine

PROJECT_TITLE: Neurobehavioral mechanisms underlying xylazine and fentanyl co-use and withdrawal


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Genetics;Neurosciences;Opioid Misuse and Addiction;Opioids;Prescription Drug Misuse;Substance Misuse

ORG_CITY: SAINT LOUIS

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Misuse of prescription opioids is a significant public health and economic burden; in 2020 in the United States, more than 9.9 million people reported prescription opioid misuse, and prescription opioids contributed to over 17,000 overdose deaths. A defining symptom of opioid use disorder is the inability to abstain from drug consumption in the face of aversive life consequences, which afflicts only a subset of individuals who take prescription opioids. Understanding the neural circuits that distinguish this subset of individuals who cannot inhibit drug consumption is necessary to predict which patients are at risk for developing opioid use disorder, and to prevent or reverse these neural circuit changes as a potential therapy.

PI_NAMEs: CREED, MEAGHAN C (contact)

PROGRAM_OFFICER_NAME: NAIR, SUNILA GOPI

PROJECT_TERMS: Ablation;Acute;Affect;American;Animals;Appetitive Behavior;Area;Attenuated;Binding;Biological Assay;Brain;Calcium;Cell Nucleus;cell type;Centers for Disease Control and Prevention (U.S.);Cessation of life;Classification;Conflict (Psychology);Consumption;Data;Deep Brain Stimulation;Detection;Drug resistance;Drug usage;Economic Burden;effective therapy;Electrophysiology (science);Etiology;experimental study;Exposure to;Extinction;Fiber;foot;Foundations;Gene Expression;gene network;Genetic;genetic manipulation;Genetic Transcription;Globus Pallidus;Glutamates;Goals;Habenula;in vivo;Individual;Individual Differences;insight;Intake;Lateral;Learning;Life;Link;Mediating;Messenger RNA;Modeling;Molecular;Motivation;Mus;neural;neural circuit;neuromechanism;Neurons;neuroregulation;Opioid;opioid misuse;opioid use;opioid use disorder;optogenetics;Output;overdose death;Oxycodone;oxycodone self-administration;patch clamp;Pathway interactions;Patients;Persons;Pharmaceutical Preparations;pharmacologic;Pharmacology;Phenotype;Photometry;Play;Population;Predisposition;prescription opioid;prescription opioid abuse;prescription opioid misuse;prevent;Public Health;Publishing;Punishment;Reporting;Resistance;Rewards;Ribosomes;RiboTag;Risk;Rodent;Role;Self Administration;Shock;Site;Symptoms;Synapses;Synaptic plasticity;Synaptic Transmission;Therapeutic;tool;Translating;Translations;treatment strategy;United States;Work

PROJECT_TITLE: Dissecting ventral pallidal plasticity in punishment-resistant opioid self-administration

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Biomedical Imaging;Biotechnology;Cancer;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Lung Cancer;Lymphatic Research;Precision Medicine;Prevention;Rare Diseases;Rural Health;Social Determinants of Health;Tobacco;Tobacco Smoke and Health

ORG_CITY: MORGANTOWN

ORG_NAME: WEST VIRGINIA UNIVERSITY

ORG_STATE: WV

PHR: PROJECT NARRATIVE This research study will provide new information on the mechanisms by which tobacco-induced genetic damage leads to the earlier death of Appalachian individuals harboring oral tumors with the worst clinical outcomes. The proposal will systematically evaluate specific, novel tobacco-related genes that have not been previously studied for tumor-promoting effects in oral cancer other cancer type, offering new insight into potential druggable targets in Appalachian and other patient populations with high tobacco use and DNA-damaging risk factors.

PI_NAMEs: WEED, SCOTT A (contact)

PROGRAM_OFFICER_NAME: IIDA, HIROKO

PROJECT_TERMS: 11q13;18F-fluorothymidine;3-Dimensional;Ablation;Address;Apoptotic;Appalachian Region;Automobile Driving;Behavior;Biological Assay;cancer imaging;cancer type;Candidate Disease Gene;Carcinogens;Cell Cycle;cell growth;Cell Line;Cell Physiology;Cell Proliferation;Cells;Cervical;Cervical lymph node group;Cessation of life;chemical spill;Chromosome Mapping;Chromosomes;Chronic;Clinical;Clinical Data;cohort;Cultured Cells;Data;Databases;Disease;Disparate;Disparity;DNA Damage;drug candidate;Drug Targeting;druggable target;economic disparity;Evaluation;experimental study;Exposure to;Flow Cytometry;fluorodeoxyglucose;Foundations;Future;Gene Expression;Gene Expression Profile;gene function;Genes;Genetic;Genetic Induction;genetic signature;Genomics;Geography;Goals;Growth;Head and Neck Cancer;head and neck cancer patient;Head and Neck Squamous Cell Carcinoma;high risk;Histologic;HPV negative;HPV-negative head and neck cancer;Human Papillomavirus;Image;imaging modality;improved;Incidence;Individual;Informatics;insight;Invaded;knock-down;Knowledge;Light;Lighting;Link;Lymph Node Involvement;malignant mouth neoplasm;Malignant Neoplasms;Measures;Medical;medically underserved;Membrane Fluidity;Membrane Microdomains;Metabolic;Metabolism;Metastatic Neoplasm to Lymph Nodes;Microscopy;Modeling;Molecular;mortality;mortality risk;mouse model;Mouth Neoplasms;Mus;Nature;neoplastic cell;new therapeutic target;Nodal;novel;novel therapeutic intervention;Oncogenic;Oncology;Outcome;overexpression;Pathologic;patient population;Patient-Focused Outcomes;Patients;Phenotype;Population;Positron-Emission Tomography;Proliferating;promoter;Property;Proteins;Publishing;Refractory;Refractory Disease;Research;research clinical testing;research study;Resistance;Rest;Risk;Risk Factors;Role;Rural;Rural Appalachia;screening;Signal Transduction;Smoke;Smoking;Smoking Status;Structure;survival disparity;Survival Rate;System;Testing;therapeutic biomarker;therapeutic development;Therapeutic Intervention;Tobacco;Tobacco use;tobacco user;Tongue;treatment stratification;tumor;tumor growth;tumor progression;Tumor Promotion;tumor xenograft;Vulnerable Populations;waterborne;Work

PROJECT_TITLE: Evaluation of smoking-associated genes in disparate Appalachian head and neck cancer

STUDY_SECTION: CE

STUDY_SECTION_NAME: Cancer Etiology Study Section[CE]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Genetics;Neurosciences;Sleep Research

ORG_CITY: PHILADELPHIA

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative This project uses the Drosophila genetic model to investigate mechanistic relationships between the innate immune system, lipid homeostasis, and the unfolded protein response that underlie sleep during sickness. Specifically, we test the hypothesis that through a negative feedback mechanism, an over production of antimicrobial peptides dampens the ability of cells to mount an appropriate recovery response, leading to sustained excess sleep characteristic of sickness behavior. Findings from this project will have implications for mechanisms underlying illness-associated unrefreshing sleep and fatigue in humans.

PI_NAMEs: NAIDOO, NIRMALA NIRINJINI;WILLIAMS, JULIE A (contact)

PROGRAM_OFFICER_NAME: WHITTEMORE, VICKY R

PROJECT_TERMS: Acute;acute stress;Address;Affect;Anatomy;anti-microbial peptide;Autoimmune;Back;Bacterial Infections;Behavior;Behavioral Genetics;Binding Proteins;Biochemical;Biological Assay;Brain;Cells;Characteristics;Chronic;Chronic Fatigue Syndrome;Chronic stress;Data;dietary approach;Disease;Down-Regulation;Drosophila genus;Drowsiness;Enzymes;Fatigue;Feedback;fly;Genes;Genetic;genetic approach;Genetic Models;Goals;Homeostasis;Human;Immune;Immune response;Immune signaling;Immune system;in vivo;Infection;Injury;innate immune function;Innate Immune Response;Innate Immune System;Inositol;knock-down;Lead;Link;Lipid Bilayers;lipid metabolism;lipidomics;Lipids;Luciferases;Mammals;Mediating;Messenger RNA;Metabolic;Metabolism;mutant;Nature;neoplastic;Neuroglia;novel;Nuclear;overexpression;Pathway interactions;Patients;Peptides;pharmacologic;prevent;Production;Proteins;real time monitoring;Recovery;Reporter;Reporting;response;Role;Signal Pathway;Signal Transduction;Sleep;Sleep Deprivation;Stress;stress reduction;stressor;Testing;Time;Tissues;transcription factor;Wakefulness;XBP1 gene

PROJECT_TITLE: Interactions between the immune response and lipid homeostasis in regulating sleep during sickness

STUDY_SECTION: BNRS

STUDY_SECTION_NAME: Behavioral Neuroendocrinology, Neuroimmunology, Rhythms, and Sleep Study Section [BNRS]


ORG_STATE: CA

PHR: Project Narrative Recently a number of electronic cigarettes (EC) companies have marketed products with vaping liquids that are advertised as “tobacco-free”, meaning they contain “synthetic” nicotine and therefore are not subject to existing FDA tobacco regulations. Nicotine can exist as two optical isomers (enantiomers) – (S)- and (R)-nicotine, which have different pharmacologic properties – and most synthetic nicotine products are comprised of a combination (racemic mixture) of the two. We propose to conduct a human clinical pharmacology study using stable isotope methodology to compare pharmacokinetics, metabolism, subjective, cardiovascular effects and self-administration of vaped (S)- and (R)- nicotine and racemic nicotine, which will provide important information for appropriate FDA regulation.

PI_NAMEs: BENOWITZ, NEAL L (contact)

PROGRAM_OFFICER_NAME: HERRMANN, EVAN SULLIVAN

PROJECT_TERMS: abuse liability;Affect;Analytical Chemistry;animal data;Animals;Area;Behavior;Blood flow;Blood Pressure;Carbon;cardiovascular effects;Cardiovascular system;Catecholamines;Clinical Pharmacology;Consumption;craving;Cross-Over Studies;Deuterium;Drug Kinetics;Electronic cigarette;electronic cigarette user;electronic liquid;enantiomer;experience;Half-Life;Heart Rate;Human;Image;interest;Isomerism;Label;Liquid substance;Lung;Manufacturer;Marketing;Metabolic;Metabolism;Methodology;Nicotine;nicotine self-administration;Optics;Outcome Measure;Pathway interactions;Pattern;pharmacokinetics and pharmacodynamics;pharmacologic;Pharmacology;Pharmacology Study;Plasma;Process;Property;Qualifying;Regulation;Research;response;Rewards;Self Administration;Skin;stable isotope;Standardization;Synthesis Chemistry;Time;Tobacco;tobacco control;tobacco products;tobacco regulation;tobacco-free;Urine;vaping;Withdrawal Symptom;Youth

PROJECT_TITLE: Clinical Pharmacology of Nicotine Enantiomers

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-RPHB-P(56)]


ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: The proposed training in critical thinking, communication, rigor and reproducibility, professional and career development as well as disciplinary knowledge is supported by literature findings of critical skills needed by biomedical Ph.D. graduates who will work in multiple settings. This includes training in mentorship, time management, working with and leading teams, career planning including key competencies in teaching and mentoring, communication, leadership self-awareness and professionalism. PSTP trainees will receive this training both from our program and from professionals in the School of Medicine and Graduate School who can complement the instruction provided by the highly experienced Ph.D. mentors associated with the program. Training provided by these entities is open to all Ph.D. candidates, and so allows us to synergize with other T32 (and other training programs) present at Duke University.

PI_NAMEs: KUHN, CYNTHIA M (contact)

PROGRAM_OFFICER_NAME: BLATCH, SYDELLA ANNE

PROJECT_TERMS: Grant;pharmacologic;Science;Training

PROJECT_TITLE: Pharmacological Sciences Training Grant

STUDY_SECTION_NAME: Training and Workforce Development Study Section - B[TWD-B]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Hematology;Human Genome;Lymphatic Research;Lymphoma;Orphan Drug;Rare Diseases

ORG_CITY: CAMBRIDGE

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

ORG_STATE: MA

PHR: Project Narrative  Genome-wide sequencing technologies have allowed an unprecedented discovery of somatic mutations in chromatin and epigenetic regulators in human cancers, including gain-of-function or loss-of-function mutations in Polycomb Repressive Complex 2 (PRC2). The proposed research will determine mechanisms of how PRC2 dysregulation disrupts the chromatin landscape and leads to cancer formation. These findings are expected to illuminate new strategies for development of cancer therapies.

PI_NAMEs: PATRIOTIS, AGATA EWA (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: Address;Advanced Malignant Neoplasm;Allosteric Regulation;Architecture;Award;B-Cell Lymphomas;Binding;Biochemistry;Cancer Biology;cancer cell;Cancer Model;cancer prevention;cancer therapy;Catalysis;Cell Communication;Cell Physiology;Cells;chemotherapy;Chromatin;Chromatin Remodeling Factor;Clonal Evolution;Complex;Coupled;Data;Development;Drug resistance;drug resistance development;Ectoderm;Embryo;Epigenetic Process;epigenetic regulation;epigenomics;experience;EZH2 gene;Focus Groups;gain of function;gain of function mutation;Gene Expression;Gene Mutation;Genes;Genetic Screening;genome-wide;Genomics;genotoxicity;Goals;Heterochromatin;Heterogeneity;Histone H3;Histones;Human;In Vitro;in vivo;insight;large cell Diffuse non-Hodgkin's lymphoma;loss of function;loss of function mutation;Lymphoma;Lysine;Maintenance;Malignant - descriptor;Malignant Neoplasms;malignant state;Methylation;Microscopy;Modeling;Modification;Molecular;Molecular Biology;mutant;Mutate;Mutation;N-terminal;Neoplasms;Neoplastic Processes;Neurofibrosarcoma;novel;novel strategies;Pathway interactions;Patients;Pharmaceutical Preparations;Phase;Phenocopy;Polycomb;Post-Translational Protein Processing;Postdoctoral Fellow;preclinical development;Process;programs;Proliferating;Radiation therapy;reconstitution;Regulation;Research;Resistance;Role;shift work;Somatic Mutation;System;Technical Expertise;Techniques;Technology;Therapeutic;Therapeutic Intervention;transcriptomics;tumor;Work

PROJECT_TITLE: Dissecting the molecular mechanisms of PRC2 dysregulation in cancer


PHR: Project Narrative Multiciliated cells are a crucial component of the defense mechanism of the lung against inhaled biological agents and are a common target of respiratory virus. These studies will advance our understanding of the mechanisms hijacked by respiratory virus to infect multiciliated cells and cause pulmonary disease

PI_NAMEs: CARDOSO, WELLINGTON V. (contact)

PROGRAM_OFFICER_NAME: DONG, GANG

PROJECT_TERMS: 2019-nCoV;Active Sites;Address;Adult;Air;Airway Disease;airway epithelium;Apical;Biological Products;Cell Differentiation process;Cells;Centrioles;Chimeric Proteins;Cilia;cilium biogenesis;Cytoplasm;Cytoplasmic Granules;Data;Defect;Defense Mechanisms;Enzymes;epithelial stem cell;Epithelium;Event;Fluorescent in Situ Hybridization;Human;Infant;Influenza A virus;Inhalation;Knowledge;Label;Liquid substance;long-term sequelae;Lung;Lung Diseases;Mammalian Cell;Mediating;Messenger RNA;MicroRNAs;Morbidity - disease rate;Morphology;mRNA Transcript Degradation;Mucociliary Clearance;Mus;mutant;Names;novel;pathogen;Pathogenesis;pathogenic virus;Pathologic;Pathway interactions;Peptide Initiation Factors;Phenotype;Play;Poly(A)-Binding Proteins;polypeptide;Production;programs;Protein Biosynthesis;Proteins;Public Health;Puromycin;recruit;Reporting;respiratory;Respiratory physiology;Respiratory syncytial virus;Respiratory Syncytial Virus Infections;Respiratory System;Respiratory Tract Infections;respiratory virus;Ribonucleoproteins;Ribosomal Proteins;ribosome profiling;RNA immunoprecipitation sequencing;Role;Signal Transduction;single molecule;System;Testing;transcriptome;Translating;Translations;Trinucleotide Repeats;Viral Proteins;Virus Diseases

PROJECT_TITLE: Local translation and viral infection in the airway epithelium

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Genetics;Infectious Diseases;Influenza;Lung;Pneumonia and Influenza;Women's Health Research

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE Many of the key pathways that allow different respiratory viruses to induce greater disease or that link important molecules, such as hormones, to respiratory virus infection remain unknown. The proposed research program will leverage recently developed bioinformatics algorithms and existing public datasets to identify new pathways that influenza and SARS-CoV-2 viruses exploit and pathways linking infection to hormone activity. Completion of the study will help in identifying new candidate therapeutic targets for treating respiratory infection.

PI_NAMEs: SHOEMAKER, JASON EDWARD (contact)

PROGRAM_OFFICER_NAME: BOZICK, BROOKE ALLISON

PROJECT_TERMS: 2019-nCoV;Address;Adoption;Adult women;Affect;Age Years;Algorithms;Automobile Driving;Binding;Bioinformatics;Cells;Cessation of life;Code;cohort;Communicable Diseases;Communities;Computer Analysis;COVID-19;CRISPR screen;Data;Data Set;Development;Disease;drug candidate;Drug resistance;effectiveness evaluation;Epidemiology;Epithelial Cells;Estradiol;experience;Female;Future;Gene Expression;Genomics;Goals;Gonadal Steroid Hormones;Hormones;Hospitalization;Human;human data;Immune;Immune response;in silico;Infection;Infectious Diseases Research;Inflammatory;Inflammatory Response;Influenza;Influenza A Virus, H1N1 Subtype;Influenza A Virus, H3N2 Subtype;influenza infection;influenzavirus;Integration Host Factors;Knowledge;Link;mathematical model;Mediating;men;Molecular;molecular drug target;Morbidity - disease rate;mortality;Nasal Epithelium;National Institute of Allergy and Infectious Disease;Natural regeneration;Nose;novel;pandemic disease;pathogen;Pathway interactions;patient variability;Patients;Policies;pressure;Process;programs;Proteins;Publishing;Research;respiratory;respiratory infection virus;Respiratory Tract Infections;respiratory virus;response;seasonal influenza;secondary analysis;sex;Signal Transduction;Small Interfering RNA;therapeutic candidate;therapeutic target;therapy development;Time;Validation;Viral Load result;Virus;virus host interaction;Virus Replication;whole genome;Woman;Work;young adult

PROJECT_TITLE: Leveraging Pathogen-Host Networks to Identify Virus-specific and Estradiol-regulated Mechanisms during Respiratory Infection

STUDY_SECTION: MABS

STUDY_SECTION_NAME: Modeling and Analysis of Biological Systems Study Section[MABS]


FUNDING_MECHANISM: SBIR-STTR RPGS

ORG_CITY: Baltimore

ORG_NAME: SCANOGEN, INC.

PHR: Project Narrative We propose the development of a novel sample-to-answer test for rapid detection and identification of bacteria directly in whole blood for the diagnosis of bloodstream infections.

PI_NAMEs: CELEDON, ALFREDO ANDRES (contact)

PROGRAM_OFFICER_NAME: RITCHIE, ALEC

PROJECT_TERMS: Achievement;antimicrobial;Architecture;assay development;Bacteremia;Bacteria;Biological Assay;Blood;Clinical;Clinical Research;commercialization;Complication;cost effective;Death Rate;Detection;detection limit;detection method;Development;Device or Instrument Development;Diagnosis;Diagnostic;Engineering;fungus;Goals;Head;Hospitals;Hour;improved;Infection;instrument;Length of Stay;Life;Manuals;manufacturability;manufacture;Methods;Microbiology;microorganism;Molecular;mortality;multidisciplinary;multiplex assay;novel;operation;Organism;pathogen;Patient-Focused Outcomes;Patients;Performance;Phase;Physicians;Pilot Projects;Preparation;Procedures;Process;protocol development;Protocols documentation;Publishing;rapid detection;rapid test;Reagent;Recommendation;Resources;Ribosomal RNA;Sampling;Sensitivity and Specificity;Sepsis;septic patients;single molecule;Specificity;System;targeted treatment;Technology;Testing;Time;United States Food and Drug Administration;Universities;usability;validation studies;Whole Blood;Work

PROJECT_TITLE: Culture and amplification-free bacterial sepsis diagnosis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AIDC-V(13)]


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Relevance to Public Health: Genome rewiring events, through translocations, deletions, and even massive chromosomal rearrangements, contribute to genome instability associated with many human diseases, including a significant portion of cancers and inherited or spontaneous diseases. Furthermore, many classes of noncoding RNAs participate in genome remodeling pathways or the maintenance of genome integrity, and their loss or dysfunction can increase the frequency of genome rearrangements, resulting in either deletion of tumor-suppressing genes, formation of chimeric genes, or over-expression of genes that promote tumor stability. The extreme degree of natural genome editing events in Oxytricha make it unparalleled as a model system to study genome stability, and similar mechanisms that may contribute to genome instability and cancer in humans.

PI_NAMEs: LANDWEBER, LAURA F (contact)

PROGRAM_OFFICER_NAME: VATAKIS, DIMITRIOS NIKOLAOS

PROJECT_TERMS: Address;Adenine;Architecture;Biochemistry;Biological Models;Biology;chimeric gene;Chromatin;Chromosomal Rearrangement;comparative genomics;Complex;Crying;Development;Disease;DNA;Eukaryota;Event;Evolution;Frequencies;Functional disorder;Gene Expression;Gene Rearrangement;Genes;Genetic;genetic architecture;Genome;genome editing;genome integrity;Genome Stability;Genomic Instability;Goals;Human;human disease;Inherited;insight;Knowledge;Maintenance;Malignant Neoplasms;Methylation;microbial;Molecular;Molecular Genetics;Organism;overexpression;Oxytricha;Pathway interactions;Process;Public Health;Research;RNA;RNA Editing;RNA Processing;RNA-Binding Proteins;Role;System;tool;Tumor Promotion;Tumor Suppressor Genes;Untranslated RNA;Variant

PROJECT_TITLE: Understanding Complex Genome Editing and RNA Biology in Oxytricha

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


NIH_SPENDING_CATS: Aging;Atherosclerosis;Bioengineering;Biotechnology;Cardiovascular;Diabetes;Gene Therapy;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Nanotechnology;Obesity

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: PROJECT NARRATIVE Atherosclerotic cardiovascular disease is the leading cause of mortality worldwide and is also a major cause of death in obesity-induced type 2 diabetes, owing to the development and progress of dangerous atherosclerosis plaques that will ultimately lead to blood clot formation and death in the form of heart attacks. The long-term objective of this project is to expand the targeting possibilities of RNA interference (RNAi) therapy, which can specifically silence individual genes including those that are considered “undruggable”, beyond the liver for treatment of chronic diseases like atherosclerosis. We will develop a novel and robust RNAi strategy with long duration of action for silencing a unique kinase that is activated in both advanced atherosclerosis and obesity- induced type 2 diabetes, which we expect could lead to development of potent therapeutics for atherosclerosis and cardiometabolic disease.

PI_NAMEs: SHI, JINJUN  (contact)

PROGRAM_OFFICER_NAME: CHEN, JUE

PROJECT_TERMS: Acetylgalactosamine;Address;Apoptotic;Area;Arterial Fatty Streak;Atherosclerosis;Biocompatible Materials;Blood;Blood Circulation;Blood coagulation;Calcium;Calmodulin;Cardiometabolic Disease;Categories;Cause of Death;Cells;Cessation of life;Chemicals;Chemistry;Chronic Disease;Clinical;clinical development;Collaborations;Complex;Coronary heart disease;Dangerousness;Development;Disease;Dose;Drug Kinetics;effective therapy;efficacy evaluation;Engineering;ethylene glycol;FDA approved;Formulation;Frequencies;Galactose;Gene Silencing;Generations;Genes;Genetic Diseases;Goals;Half-Life;Hepatocyte;Human;Impairment;improved;In Vitro;in vivo;in vivo Model;Individual;Inflammation;Injections;Insulin Resistance;lead candidate;Ligands;lipid nanoparticle;Lipids;Liver;Macrophage;Mediating;Mediator;Modeling;Modification;mortality;mouse model;Mus;Myocardial Infarction;nanoparticle;Nanotechnology;Nature;Necrosis;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;obesity treatment;Outcome;Peptides;Phagocytosis;Pharmaceutical Preparations;Phosphotransferases;Process;Resolution;RNA Interference;RNA Interference Therapy;Safety;Science;Series;siRNA delivery;Small Interfering RNA;success;Surface;surface coating;System;Technology;Testing;Therapeutic;therapeutic RNA;therapeutic siRNA;therapeutic target;Thick;uptake;western diet;Work

PROJECT_TITLE: Long-Acting RNAi Therapy for Atherosclerosis and Insulin Resistance

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Data Science;Dementia;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: NARRATIVE Understanding mechanisms underlying sex-related vulnerabilities relevant to Alzheimer's disease (AD) from cells to networks is critical to interrogate disease processes and develop effective sex stratified, precision medicine derived therapies. We present an innovative, multidisciplinary strategy to study proteome-wide protein-protein interactions in disease to investigate interactome network and connectome dysfunction in the context of sex- specific vulnerabilities in brain cells and regions across the AD spectrum. Outcomes are highly relevant insights underlying sex difference driven molecular mechanisms and the influence of differential risk factors negatively impacting brain function at the cell, network, and connectome levels as they relate to the transition from healthy aging to pathologic neurodegeneration, topics of high interest under RFA-AG-21-029.

PI_NAMEs: CHIOSIS, GABRIELA  (contact);GINSBERG, STEPHEN D

PROGRAM_OFFICER_NAME: CHAKROBORTY, SHREAYA

PROJECT_TERMS: Address;Affect;Aging;Alzheimer's Disease;Alzheimer's disease brain;Autopsy;Bioinformatics;Biological;biological systems;Biology;Brain;brain cell;Brain region;brain tissue;cell type;Cells;Cerebellum;Chemicals;Clinical;Cognitive;Communities;comorbidity;Complex;Complex Analysis;complex data;Computational algorithm;Computer Analysis;computerized data processing;connectome;Data;Data Analytics;Data Set;data visualization;Defect;Dementia;Deposition;design;Development;Disease;disease heterogeneity;disease phenotype;Environment;Equipment and supply inventories;Freezing;frontal lobe;Functional disorder;functional outcomes;Generations;Genes;Genetic;genome wide association study;Genotype;Global Change;healthy aging;Heterogeneity;Hippocampus;Hormonal;Human;Image;Impaired cognition;Individual;innovation;insight;interest;invention;Knowledge;Knowledge Portal;large scale data;laser capture microdissection;Link;Maps;Measures;member;Metadata;mild cognitive impairment;Mining;Molecular;multidisciplinary;Nature;Nerve Degeneration;network dysfunction;Neuroglia;Neurons;neuropathology;novel strategies;Online Systems;open source;Outcome;Output;Pathologic;Pathway interactions;Patients;Phenotype;Phenotypic Sex;Positioning Attribute;precision medicine;Prevention;Process;protein protein interaction;Proteins;Proteome;Recording of previous events;Resources;response;Risk Factors;Sampling;Severities;sex;Sex Differences;Site;Sorting;spatiotemporal;Specimen;stoichiometry;stressor;System;Technology;Temporal Lobe;Testing;therapy development;Time;Transcript;Translating;user-friendly;web platform

PROJECT_TITLE: Impact of sex differences on the trajectory of interactome dysfunctions across the AD spectrum


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Eye Disease and Disorders of Vision;Physical Injury - Accidents and Adverse Effects;Prevention;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Wound Healing and Care

ORG_CITY: COLLEGE STATION

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR

PHR: Narrative  Ocular exposure to mustard agents has harmfully affected thousands of soldiers and civilians, yet an effective medical countermeasure against the ocular injury of mustard agents still does not exist. The proposed study will investigate whether extracellular vesicles (EVs) derived from mesenchymal stem cells (MSCs) can be developed as a topical drug for the treatment of mustard-induced ocular injury. Successful completion of the proposed study will provide valuable preclinical data of MSC-derived EVs in vesicant-induced corneal injury, which could facilitate the development of new and improved medical countermeasures against mustard agents.

PI_NAMEs: LEE, RYANG HWA  (contact)

PROGRAM_OFFICER_NAME: ARAJ, HOUMAM H

PROJECT_TERMS: Adherent Culture;Affect;Alkylating Agents;Angiogenesis Inhibitors;Angiogenic Factor;Anti-Inflammatory Agents;Apoptosis;Apoptotic;Appearance;bevacizumab;Biological Assay;Biological Markers;Blindness;Bulla;Burn injury;CASP3 gene;Cell Death;Cell Death Induction;Cells;Chronic;Clinical;clinical application;Clinical assessments;Collaborations;Combined Modality Therapy;comparison control;Control Groups;Cornea;corneal epithelial wound healing;corneal epithelium;Corneal Injury;cost effective;cytokine;Cytoprotection;Data;Development;Disease;Drug Delivery Systems;Engineering;Epithelial Cells;Exposure to;extracellular vesicles;Eye;Eye Injuries;Fibrosis;gene delivery system;Genes;Goals;Hour;Impairment;improved;in vivo;Inflammation;Inflammatory;Inflammatory Response;Infrastructure;Injury;innovation;insight;Intervention;Keratopathy;Lesion;limbal;manufacturing systems;Matrix Metalloproteinase Inhibitor;Matrix Metalloproteinases;Mechlorethamine;Mediating;medical countermeasure;Mesenchymal;Mesenchymal Stem Cells;MicroRNAs;Modeling;Mustard;Mustard Agent;Mustard Gas;neovascularization;nerve supply;Neutrophil Infiltration;Oryctolagus cuniculus;overexpression;Pain;Parents;Pathologic;Pathology;Pathway interactions;Patients;Pharmaceutical Preparations;Pharmacotherapy;Plasmids;pre-clinical;Pre-Clinical Model;preconditioning;prevent;Prevention;Preventive;Proteins;rational design;Rattus;Research;Risk;Safety;Severities;Signal Transduction;Small Interfering RNA;Soldier;stem;stem cell expansion;stem cell therapy;stem cells;Sterility;Steroids;Stromal Cells;symptom treatment;System;targeted agent;Testing;Therapeutic;Therapeutic Effect;therapeutic evaluation;therapeutic miRNA;therapeutic protein;Time;TLR4 gene;TNF gene;TSG-6 protein;Vascular Endothelial Growth Factors;Vesicants;Viral;Visual impairment

PROJECT_TITLE: Extracellular Vesicles derived from Mesenchymal Stem Cells as an Effective Medical Countermeasure against Mustard Induced Ocular Injury

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-KUDS-F(54)]


NIH_SPENDING_CATS: Hematology

ORG_CITY: Aurora

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative The fundamental objective of our Trauma Research Center Training Program is to inspire the next generation of surgical trainees to pursue a career that includes basic science and translational investigations. Our secondary objective is to recruit capable surgeons as surgical investigators to the field of academic trauma surgery, in which lack of research has become a national crisis. As trauma continues to be the leading cause of death for individuals younger than 45 years of age, and the most common cause of preventable death is uncontrolled bleeding, training the next generation of clinician investigators in this field is our fundamental goal.

PI_NAMEs: COHEN, MITCHELL  (contact);KOVACS, ELIZABETH J.

PROGRAM_OFFICER_NAME: PRICE, AMANDA ALISE

PROJECT_TERMS: trauma induced coagulopathy

PROJECT_TITLE: Mechanisms of Trauma-Induced Coagulopathy


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Data Science;Drug Abuse (NIDA only);Emergency Care;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Opioid Misuse and Addiction;Opioids;Patient Safety;Substance Misuse

ORG_CITY: Chicago

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative Opioid overdose is a leading cause of death in the United States with approximately 49,000 deaths and 1.5 million Emergency Department (ED) encounters related to opioid misuse annually. ED-based interventions for opioid misuse are effective but limited in scale by barriers to the accurate detection of all patients who could benefit from these interventions. This proposal seeks to use machine learning approaches to better identify and characterize ED patients with opioid misuse so that timely treatments can be targeted to decrease opioid-related mortality.

PI_NAMEs: CHHABRA, NEERAJ  (contact)

PROGRAM_OFFICER_NAME: WILEY, TISHA R  A

PROJECT_TERMS: Academic Medical Centers;Accident and Emergency department;advanced analytics;Affect;Algorithms;American;Area;Biometry;career development;Cause of Death;Cessation of life;Characteristics;Clinical;Clinical Ethics;clinically relevant;Cluster Analysis;Code;cohort;cooking;Cost Savings;County;COVID-19 pandemic;Data;Data Science;Data Sources;Databases;Decision Trees;deep neural network;Detection;Development Plans;Diagnosis;Discrimination;Disease;Electronic Health Record;Emergency Care;Emergency Department patient;Emergency Department-based Intervention;Emergency Health Services;Ensure;Equity;Ethics;Evidence based intervention;Foundations;Fright;Future;Goals;Grant;Harm Reduction;Health;Hospitalization;Hour;Human;improved;Individual;individual patient;innovation;Institution;Intervention;Investigation;K-Series Research Career Programs;Link;Logistic Regressions;Machine Learning;machine learning algorithm;machine learning model;Manuals;Measures;Medical;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Methods;model building;Modeling;Morbidity - disease rate;mortality;multidisciplinary;multiple data sources;Natural Language Processing;Opioid;opioid misuse;opioid mortality;opioid overdose;opioid use disorder;Outcome;Patient Care;patient engagement;patient oriented;Patient Self-Report;Patient-Focused Outcomes;patient-level barriers;Patients;Performance;Phenotype;predictive modeling;premature;prescription monitoring program;prevent;Process;programs;prospective;Provider;Research;research and development;Research Personnel;Resources;Risk;Role;screening;skills;social bias;Stigmatization;substance use;Systematic Bias;targeted treatment;Techniques;Testing;Time;Toxicology;Training;United States

PROJECT_TITLE: Machine learning approaches for the detection of emergency department patients with opioid misuse

STUDY_SECTION: CDMA

STUDY_SECTION_NAME: Clinical Data Management and Analysis Study Section[CDMA]


ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative Research Training in Pulmonary Immunology and Allergy at MGH is designed to prepare the next generation of physician-scientists and PhD-scientists who, through mentored research and rigorous training in new technologies, will be well prepared to be leaders in pulmonary immunology and allergy related biomedical research. The overall goal of the program is to educate trainees so that they can contribute to our understanding of the basis of inflammatory lung disorders and allergic diseases, and translate these findings to better clinical care for patients with these important diseases.

PI_NAMEs: CHRISTIANI, DAVID C;LUSTER, ANDREW D (contact)

PROGRAM_OFFICER_NAME: ESPINOZA-PINTUCCI, MARISOL

PROJECT_TITLE: Research Training in Pulmonary Immunology and Allergy at Massachusetts General Hospital

STUDY_SECTION: NITM

STUDY_SECTION_NAME: NHLBI Institutional Training Mechanism Study Section[NITM(JA)]