NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Genetics;Human Genome;Liver Disease;Pediatric;Rare Diseases

ORG_CITY: SALT LAKE CITY

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Cholestatic liver diseases are a significant source of morbidity and mortality in infants and children. Because these diseases are rare, a multicenter collaborative network such as the Childhood Liver Disease Research Network is necessary to accumulate a sufficient cohort to understand the causes, natural histories of rare liver diseases and develop new therapies to treat them. The proposed Clinical Center will continue to enroll and longitudinally follow eligible participants and contribute biospecimens and relevant data. These studies will broaden the scientific understanding of the etiology, natural history, and biology of liver disease, improve therapy for these disorders, and further the aims of the Childhood Liver Disease Research Network.

PI_NAMEs: GUTHERY, STEPHEN L (contact)

PROJECT_TERMS: Adolescent;Adopted;Agreement;Biliary Atresia;Biochemistry;Bioinformatics;Biological;Biology;Child;Childhood;Cholestasis;clinical center;Clinical Data;Clinical Trials Data Monitoring Committees;cohort;Collection;Complex;Data;Data Coordinating Center;data dissemination;data hub;data sharing;design;Diagnosis;Diagnostic;Disease;eligible participant;Enrollment;Etiology;exome;experience;follow-up;Funding;Future;Genetic;Genetic Predisposition to Disease;genetic variant;Genomic approach;genomic data;Genomic medicine;Genomics;Goals;Health Insurance Portability and Accountability Act;High Performance Computing;improved;Industry;Infant;Infant Mortality;Infrastructure;innovation;Knowledge;Lead;Leadership;Liver diseases;Mission;Morbidity - disease rate;National Institute of Diabetes and Digestive and Kidney Diseases;Natural History;Nature;novel therapeutics;Participant;participant enrollment;Patients;Pediatric Hospitals;Performance;performance site;Physiology;Policies;primary sclerosing cholangitis;Principal Investigator;Process;Protocols documentation;Qualifying;Rare Diseases;Reporting;Research;Research Personnel;Secure;Shipping;Site;Source;Specimen;success;support network;Universities;Utah;validation studies;whole genome

PROJECT_TITLE: Intermountain West Clinical Center for a Childhood Liver Disease Research Network

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-Q (M1)]


ADMINISTERING_IC: DK

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Digestive Diseases;Genetics;Inflammatory Bowel Disease

ORG_CITY: Aurora

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Narrative Pathological activation of intestinal intraepithelial lymphocytes (IELs) is implicated in exacerbation of inflammatory bowel disease (IBD), but the mechanisms that suppresses IEL activation during intestinal inflammation remain unknown. I discovered the novel regulatory roles of Aiolos, a transcription factor encoded by Ikzf3, in IEL activation, and this project will investigate how Aiolos-deficient IELs modulate host responses to gut inflammation. This proposed project could advance our understanding of the pathogenesis of IBD and may eventually identify novel therapeutic targets.

PI_NAMEs: YOMOGIDA, KENTARO  (contact)

PROGRAM_OFFICER_NAME: SASLOWSKY, DAVID E

PROJECT_TERMS: ATAC-seq;Autoimmune Diseases;B-Cell Activation;Binding;Binding Sites;CD94 Antigen;Cell Maturation;cell type;Chemical Exposure;Chromatin;chromatin remodeling;Chronic;Chronic Disease;Cleavage Under Targets and Release Using Nuclease;Clinical;Colitis;cytokine;cytotoxic;Data;defined contribution;dextran sulfate sodium induced colitis;Dextrans;Diet;Disease;Enhancers;enteric infection;Enzymes;Epigenetic Process;Epithelium;Flare;Gastrointestinal tract structure;Genes;Genetic Predisposition to Disease;Granzyme;gut homeostasis;gut inflammation;Heterogeneity;histone modification;Immune;Immune response;Infection;Inflammation;Inflammatory Bowel Diseases;insight;Interferon Type II;Interferons;intestinal epithelium;Intestines;intraepithelial;Invaded;Lymphocyte;Lymphocyte Activation;Lymphocyte Function;Maintenance;microbiota;Modeling;Modification;Mucositis;Mus;Mutation;Natural Killer Cells;new therapeutic target;novel;novel therapeutics;pathogen;Pathogenesis;Pathologic;Patients;Play;response;Role;Salmonella typhimurium;Sodium;Sodium Chloride;Techniques;tissue repair;Tissues;transcription factor;Transcription Repressor;treatment response;Zinc Fingers

PROJECT_TITLE: Impact of Aiolos on intestinal intraepithelial lymphocytes

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


ADMINISTERING_IC: HL

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: LA JOLLA

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: Narrative There are currently limited treatment options for improving endothelial dysfunction in vascular diseases, a leading cause of morbidity and mortality. Activated Protein C (APC) is a promising therapeutic that promotes multiple cytoprotective effects including stabilization of endothelial barriers, anti-inflammatory responses and anti-apoptotic activities. The proposed research is important because it will advance the status of APC by understanding the mechanism by which APC activation of protease-activated receptor-1 promotes endothelial cytoprotection.

PI_NAMEs: TREJO, JOANN  (contact)

PROGRAM_OFFICER_NAME: GAO, YUNLING

PROJECT_TERMS: activated Protein C;Agonist;Anti-Inflammatory Agents;Anticoagulants;Apoptosis;Apoptotic;Arginine;ARRB1 gene;ARRB2;beta-arrestin;Binding;Caveolae;caveolin 1;Cell membrane;Cells;CRISPR/Cas technology;Cytoprotection;desensitization;Endothelial Cells;endothelial dysfunction;Endothelium;Exhibits;Future;G-Protein-Coupled Receptors;Goals;GRK5 gene;GTP-Binding Proteins;Heterotrimeric GTP-Binding Proteins;Human;improved;In Vitro;in vivo;Inflammation;Inflammatory Response;Injury;innovation;insight;Knock-out;Ligands;Mediating;Mediator;Membrane;Membrane Microdomains;Morbidity - disease rate;mortality;N-terminal;new therapeutic target;novel;PAR-1 Receptor;Pathogenesis;Pathologic;Pathway interactions;Peptide Hydrolases;pharmacologic;Phosphorylation;Phosphotransferases;Physiological;preclinical study;receptor;Research;resilience;response;Sepsis;Signal Induction;Signal Pathway;Signal Transduction;Site;Specificity;Sphingosine-1-Phosphate Receptor;SPHK1 enzyme;System;Testing;Therapeutic;therapeutic development;Thrombin;Transducers;Vascular Diseases

PROJECT_TITLE: Endothelial Cytoprotective Signaling by Activated Protein C/Protease-activated Receptor-1

STUDY_SECTION: CSRS

STUDY_SECTION_NAME: Cellular Signaling and Regulatory Systems Study Section[CSRS]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Kidney Disease;Orphan Drug;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases;Social Determinants of Health

ORG_CITY: CLEVELAND

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE Complex human diseases have both environmental and genetic contributors. While many independent genetic associations have been identified, missing is our understanding of how environmental exposures modify these associations. We propose here to use APOL1-mediated kidney disease as a model and eventual framework to identify these “second hits” that distinguish true at-risk patients from APOL1 renal risk variant carriers.

PI_NAMEs: CRAWFORD, DANA C (contact)

PROGRAM_OFFICER_NAME: RIVERS, ROBERT C

PROJECT_TERMS: admixture mapping;Affect;African;African American population;African ancestry;Age;Albuminuria;APOL1 gene;Arsenic;biobank;Biological Process;Biomedical Research;Black Populations;Black race;blood lead;British;built environment;Cadmium;Chronic;Chronic Kidney Failure;Clinic;clinical care;clinical risk;cohort;comparative;Complex;Data;Data Set;Development;Disease Outcome;diverse data;drug repurposing;Economics;education access;Electronic Health Record;Environment;Environmental Exposure;European;Family;Focal and Segmental Glomerulosclerosis;Genes;Genetic;genetic association;Genetic Carriers;Genetic Risk;genome repository;genome resource;genome-wide;Genomic Segment;Genomics;Genotype;Haplotypes;health disparity;Heavy Metals;Heritability;Heterogeneity;high risk;Hispanic Populations;Human;human disease;interest;Intervention;Kidney;Kidney Diseases;Kidney Transplantation;Lead;Link;low socioeconomic status;Maps;Mediating;Metal exposure;Methodology;Modeling;Modernization;Names;Neighborhoods;non-genetic;novel therapeutics;Odds Ratio;Outcome;Outcome Study;Participant;Patient risk;Patients;Phenotype;pleiotropism;polygenic risk score;Population;Population Control;Population Heterogeneity;Prevention;Prevention strategy;Publishing;Research;Resources;Risk;risk prediction model;risk stratification;risk variant;sex;Smoking;social health determinants;social inclusion;Statistical Data Interpretation;Statistical Methods;Surveys;Technology;Testing;trait;translational genetics;translational genomics;treatment strategy;United States;Variant;Work

PROJECT_TITLE: APOL1 as a model to quantify and identify environmental modifiers of genetic associations in diverse populations

STUDY_SECTION_NAME: Special Emphasis Panel[ZHG1 HGR-P (M1)]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Fentanyl Misuse and Addiction;Genetics;Neurosciences;Opioid Misuse and Addiction;Opioids;Sleep Research;Substance Misuse

ORG_CITY: WORCESTER

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

ORG_STATE: MA

PHR: PROJECT NARRATIVE Synthetic opioids like fentanyl have surpassed prescription and other illicit opioids as the primary substances used by people with opioid use disorder (OUD) and are the leading causes of fatal opioid overdose. The most common complaints of patients with OUD are disruptions to sleep and circadian rhythms, speculated to contribute to craving and relapse to opioids. Our proposal will dissect the intricate roles of circadian rhythms in key neuronal subpopulations of the striatum crucial in the regulation of opioid craving and relapse, providing new targets for the development of more effective OUD treatments.

PI_NAMEs: FREYBERG, ZACHARY ;LOGAN, RYAN W (contact)

PROGRAM_OFFICER_NAME: POLLOCK, JONATHAN D

PROJECT_TERMS: Ablation;Abstinence;Arousal;Attenuated;Behavior;Behavioral;behavioral response;Binding;Brain;cell type;Cells;ChIP-seq;Chronic;circadian;Circadian Dysregulation;circadian regulation;Circadian Rhythms;conditional knockout;Corpus striatum structure;craving;Data Set;Development;Dopamine;Dopamine D2 Receptor;dopamine D3 receptor;DRD2 gene;economic cost;effective therapy;Electrophysiology (science);excitatory neuron;Exhibits;experience;Female;Fentanyl;fentanyl exposure;fentanyl seeking;fentanyl self-administration;Future;Gene Expression;Gene Targeting;Genes;Genetic;Genetic Transcription;Glutamate Receptor;Glutamates;Human;illicit opioid;Individual;Intervention;knock-down;Knockout Mice;Link;loss of function;LoxP-flanked allele;male;Medial;Mediating;Molecular;molecular clock;motivated behavior;Motivation;Mus;National Institute of Drug Abuse;neuroadaptation;neuron loss;neuronal excitability;Neurons;novel;Nucleus Accumbens;Opiate Addiction;Opioid;opioid epidemic;opioid overdose;Opioid Receptor;opioid use disorder;overdose death;overexpression;Pathway interactions;Patients;Persons;promoter;Property;Psychological reinforcement;receptor;receptor expression;receptor function;Receptor Signaling;Regulation;Relapse;relapse risk;response;Rewards;Role;segregation;Self Administration;sex;Sex Differences;sexual dimorphism;Signal Pathway;Signal Transduction;Sleep;Sleep disturbances;Slice;substance use;Substance Use Disorder;Synapses;synthetic opioid;Testing;Time;tool;transcription factor;transcriptome sequencing;United States;women versus men;Work

PROJECT_TITLE: Novel roles for the circadian transcription factor NPAS2 and striatal dopamine D3 receptor signaling in diurnal fentanyl craving and relapse

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 BSW-N (M1)]


ADMINISTERING_IC: HS

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

PHR: PROJECT NARRATIVE Community-acquired pneumonia is a leading cause of hospitalization for children; these children are often treated with intravenous antibiotics despite emerging evidence that oral antibiotics are safe and effective. Oral antibiotics offer many benefits compared to intravenous treatment including decreased intravenous-related harms, improved patient experience by decreasing children’s pain and anxiety, and decreased hospital length of stay, resource utilization, and costs. The proposed research aims to develop and test a set of implementation strategies to increase the use of oral (and reduce intravenous) antibiotics and improve patient outcomes, which aligns with AHRQ’s aims to accelerate the spread of evidence-based practices and help healthcare systems and frontline clinicians deliver high-quality, safe, and high-value care.

PI_NAMEs: COTTER, JILLIAN M (contact)

PROGRAM_OFFICER_NAME: WILLIS, TAMARA

PROJECT_TITLE: Implementing antibiotic stewardship to improve the care of children hospitalized with pneumonia

STUDY_SECTION: HCRT

STUDY_SECTION_NAME: Healthcare Research Training [HCRT]


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Digestive Diseases;Genetics;Inflammatory Bowel Disease;Microbiome;Prevention

ORG_CITY: HOUSTON

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: Research into the genetic factors influencing the functioning of the human intestine contributes to fundamental knowledge about the intricate physiology of living systems. By unraveling the drivers of development of Inflammatory Bowel Disease (IBD), this research enhances understanding of how intestinal physiology and function are regulated to maintain homeostasis. In the long term, it paves the way for precise therapies that could significantly improve the well-being, longevity, and quality of life for individuals with IBD, addressing a major health concern.

PI_NAMEs: BLUTT, SARAH E;SAMUEL, BUCK SPARROW (contact)

PROGRAM_OFFICER_NAME: SHEA-DONOHUE, TEREZ

PROJECT_TERMS: Address;Animal Model;Area;Automobile Driving;Caenorhabditis elegans;Candidate Disease Gene;Cell model;cellular microvillus;Chronic;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;Complex;Crohn's disease;Data Set;Development;Diagnosis;Digestive System Disorders;Disease;disorder risk;DNA Sequence Alteration;dysbiosis;Environmental Risk Factor;Epithelium;Escherichia coli;European ancestry;Evaluation;experimental study;Functional disorder;Gastrointestinal tract structure;gene conservation;Gene Deletion;Gene Expression Regulation;gene function;Generations;Genes;Genetic;genetic analysis;Genetic Epistasis;Genetic Models;genetic risk factor;Genetic Screening;Genetic Transcription;Goals;Growth;gut colonization;gut dysbiosis;gut health;gut microbiome;Haplotypes;Health;high throughput screening;Homeostasis;Human;Immune;immune activation;Immune system;Impairment;improved;Individual;Inflammation;Inflammatory Bowel Diseases;insight;intestinal epithelium;Intestines;Knowledge;Longevity;Mediating;Metabolic Pathway;microbiome;Modeling;Motility;Mucous body substance;mutant;Mutation;Nematoda;Nutrient;nutrient absorption;Organism;Organoids;Orthologous Gene;Outcome;pathogen;Pathogenesis;Pathway Analysis;Pathway interactions;Patients;Peristalsis;Personal Satisfaction;Phenocopy;Phenotype;phenotypic data;Physiology;Population;Population Heterogeneity;Prevention;Proliferating;Qualifying;Quality of life;Research;reverse genetics;Risk;Risk Factors;risk variant;RNA Interference;RNA interference screen;Role;single cell sequencing;Surface;System;Testing;therapeutic target;Ulcerative Colitis;uptake;Validation;Work

PROJECT_TITLE: High-throughput functional analyses of the genetic drivers of Inflammatory Bowel Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-C (M1)]


NIH_SPENDING_CATS: Atherosclerosis;Biomedical Imaging;Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_CITY: MINNEAPOLIS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE Over 1 million Americans aged 20 years or older are diagnosed with heart failure and cardiomyopathy annually. The current method of identifying the cause of cardiomyopathy involves assessing the presence of coronary artery disease, which is flawed and may not always accurately identify the underlying cause of myocardial disease. By testing the hypothesis that a myocardial approach using cardiac magnetic resonance imaging is superior to a coronary approach, our work could lead to improved recognition of the cause of cardiomyopathy and consequently, better clinical outcomes through appropriate cause-specific treatments.

PI_NAMEs: SHENOY, CHETAN N (contact)

PROGRAM_OFFICER_NAME: DESVIGNE-NICKENS, PATRICE

PROJECT_TERMS: 20 year old;Acute;Adult;American;Biometry;cardiac magnetic resonance imaging;cardiac muscle disease;Cardiomyopathies;Cardiovascular system;Cause of Death;Cessation of life;Characteristics;Classification;Clinical;clinical practice;clinically significant;cohort;Coronary;Coronary Angiography;Coronary Arteriosclerosis;Coronary Artery Vasospasm;Data;Databases;Diagnosis;Epidemiology;Event;Funding;Gadolinium;Guidelines;Health Care Costs;Health system;Heart Diseases;Heart failure;Hospitals;improved;Institution;ischemic cardiomyopathy;Knowledge;large scale data;Left Ventricular Ejection Fraction;Medical;Methods;Minnesota;Morbidity - disease rate;mortality;multidisciplinary;Myocardial;myocardial damage;Myocardial Infarction;novel;Observational Study;Outcome;Pathology;patient stratification;Patient-Focused Outcomes;Patients;Pattern;Pattern Recognition;Prevalence;primary outcome;prognostic;randomized, clinical trials;Reference Standards;Registries;Research;Resources;Risk;secondary outcome;Testing;thrombotic;Tissues;trial comparing;Universities;Ventricular Arrhythmia;Visualization;Work;X-Ray Computed Tomography

PROJECT_TITLE: A Myocardial Approach to Identify the Cause of Cardiomyopathy

STUDY_SECTION: CCHS

STUDY_SECTION_NAME: Clinical Integrative Cardiovascular and Hematological Sciences Study Section[CCHS]


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: Columbus

ORG_DEPT: PSYCHOLOGY

ORG_NAME: OHIO STATE UNIVERSITY

PHR: Project narrative N/A. See parent award.

PI_NAMEs: KIRBY, ELIZABETH DIANA (contact)

PROGRAM_OFFICER_NAME: LAVAUTE, TIMOTHY M

PROJECT_TERMS: parent project;Research

PROJECT_TITLE: Carter Diversity Research Supplement

STUDY_SECTION: NCF

STUDY_SECTION_NAME: Neurogenesis and Cell Fate Study Section[NCF]


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Clinical Research;Clinical Trials and Supportive Activities;Congenital Structural Anomalies;Digestive Diseases;Liver Disease;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Rare Diseases

PHR: Diseases in children that impair the liver’s ability to secrete bile (e.g. biliary atresia) are the leading indication for liver transplantation in childhood. Multi-centered prospective investigations are essential to improve the health of children afflicted by these disorders. The clinical center at Baylor College of Medicine and Texas Children’s Hospital is ideally suited to participate in these prospective investigations and proposes investigations to improve outcomes in biliary atresia and primary sclerosing cholangitis.

PI_NAMEs: SHNEIDER, BENJAMIN L (contact)

PROGRAM_OFFICER_NAME: DOO, EDWARD

PROJECT_TERMS: Acceleration;Address;Alagille Syndrome;alpha 1-Antitrypsin Deficiency;American;Area;Bile Acid Biosynthesis Pathway;Bile fluid;Biliary Atresia;Biological Markers;Biological Specimen Banks;Child;Child Health;Childhood;Cholestasis;Clinical;clinical center;Clinical Data;Clinical Research;Collection;college;Cystic Fibrosis;Data Collection;Defect;Diagnosis;diagnostic criteria;Disease;disease prognosis;Disease Progression;Enrollment;Etiology;Evidence based treatment;follow-up;Hepatology;imaging study;Impairment;improved;improved outcome;Individual;Infant;insight;Investigation;Lead;Leadership;Liver;Liver diseases;liver stiffness;liver transplantation;Longitudinal Studies;Marketing;Medical;Medicine;Metadata;Methods;metropolitan;Mitochondria;Morbidity - disease rate;mortality;Natural History;Neonatal;Network-based;novel marker;Participant;participant enrollment;Pathogenesis;Patients;Pattern;Pediatric Hospitals;Pediatrics;Performance;Phase;population based;primary sclerosing cholangitis;Progressive intrahepatic cholestasis;prospective;Prospective Studies;repository;Research;Research Activity;Research Personnel;research study;Role;Sclerosing Cholangitis;Seminal;Severity of illness;Syndrome;Testing;Texas;Therapeutic;Time;Translational Research;Uncertainty;United States

PROJECT_TITLE: BCM/TCH Cholestatic Liver Disease Consortium


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Dissemination and Implementation Research;Opioid Misuse and Addiction;Opioids;Pain Research;Pediatric;Prescription Drug Misuse;Substance Misuse

ORG_CITY: LEXINGTON

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: NARRATIVE Dentists are a leading prescriber of opioids to young people, which have a particularly high risk of misusing opioids, developing a substance use disorder, or overdosing. Efforts to reduce dental opioid prescribing commonly use single interventions, do not specifically target young people, and are performed primarily in academic settings. This large study will test whether a bundled intervention of academic detailing, patient education, and non-opioid blister packs for distribution reduces opioid prescriptions to adolescents and young adults after tooth extraction.

PI_NAMEs: OYLER, DOUGLAS  (contact);ROJAS RAMIREZ, MARCIA VANESSA

PROGRAM_OFFICER_NAME: FISCHER, DENA

PROJECT_TERMS: Academic Detailing;academic intervention;Acetaminophen;Acute;Acute pain management;Address;Adolescent and Young Adult;American;Analgesics;Architecture;Behavior;Bulla;Clinic;clinical decision support;Clinical Trials Design;Cluster randomized trial;Community Trial;Country;Data;Decision Making;Dental;dental agent;Dental Care;Dental Clinics;Dental General Practice;Dentistry;Dentists;Disease;Dose;Drug Monitoring;Drug Prescriptions;Education;Educational Materials;effective intervention;Effectiveness;effectiveness evaluation;Electronic Health Record;empowerment;Enrollment;Environmental Risk Factor;evidence based guidelines;experience;Goals;health record;high risk;high risk population;Ibuprofen;implementation evaluation;implementation intervention;implementation outcomes;implementation science;improved;Individual;innovation;Intervention;Interview;Kentucky;Knowledge;Measures;member;milligram;Modeling;Morphine;Motivation;multi-component intervention;multidisciplinary;National Institute of Dental and Craniofacial Research;non-opioid analgesic;novel;novel strategies;Opioid;opioid exposure;opioid misuse;opioid use;Oral Surgeon;Oral Surgical Procedures;Outcome;Overdose;Pain;Pain interference;Pain management;Patient Education;Patients;Persons;Pharmaceutical Preparations;pill;prescription opioid;prescription opioid misuse;primary endpoint;Process;Provider;provider factors;Public Health;Recommendation;recruit;Reporting;Research;Risk;Safety;satisfaction;secondary endpoint;Site;Standardization;Substance Use Disorder;Surveys;Testing;therapy design;Tooth Extraction;Toothache;United States;Use Effectiveness;Work

PROJECT_TITLE: Empowering dentists to reduce opioid prescriptions to young people


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE Recent technology developments have made it possible to measure biomarkers for Alzheimer’s disease (AD) in blood with high accuracy, allowing for minimally invasive detection of disease pathology for early diagnosis and to follow change over time. Collection of venous blood through phlebotomy is, however, still a medical procedure performed by trained staff requiring scheduled in-person visits in clinic, or more rarely at- home, followed by sample processing in a timely manner. We will investigate and validate the use of dried blood spots (DBS), which can be collected at home by study participants themselves and be sent to the lab by mail, to measure blood-based biomarkers of AD and determine the intra-individual short-term stability of biomarkers in repeated DBS samples to provide a baseline for incorporation in clinical trials as well as in longitudinal and epidemiological observational research.

PI_NAMEs: WEBB, PIA KIVISAKK (contact)

PROGRAM_OFFICER_NAME: LUO, YUAN

PROJECT_TERMS: Acute-Phase Proteins;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer’s disease biomarker;Area;Biological Assay;Biological Markers;biomarker validation;Blood;Blood capillaries;Blood specimen;blood-based biomarker;Brain;Cerebrospinal Fluid;Characteristics;Clinic;Clinical;clinical care;Clinical Research;Clinical Trials;Collection;cost effective;cytokine;Data;Dementia;Detection;Development;Disease;DNA;Dryness;Early Diagnosis;Elderly;Enrollment;ethnoracial;Excretory function;experience;Feasibility Studies;Fingers;genome sequencing;Geography;Glial Fibrillary Acidic Protein;Goals;Home;Hormones;Immunoassay;improved;Individual;Infant;Instruction;Intercellular Fluid;Intervention;Light;Measurable;Measurement;Measures;Medical;Methods;minimally invasive;Monitor;Nerve Degeneration;neurofilament;Observational epidemiology;Observational Study;older adult;Participant;Pathology;Peptides;Performance;Persons;Pharmaceutical Preparations;Phosphorylation;Plasma;Population;Population Heterogeneity;Positron-Emission Tomography;Procedures;Protein Secretion;Proteins;Quality Control;Reporting;Reproducibility;Research;RNA;sample collection;Sample Size;Sampling;Schedule;Self Administration;Serum;Shipping;Spinal Puncture;Spottings;Sterols;Surveys;technology development;Temperature;Testing;Time;Training;treatment effect;Tumor Markers;Underrepresented Populations;Validation;Venous;Venous blood sampling;Visit;Whole Blood;whole genome

PROJECT_TITLE: Potential of Dried Blood Spots for Measurement of Alzheimer's Disease Biomarkers

STUDY_SECTION: EBIT

STUDY_SECTION_NAME: Enabling Bioanalytical and Imaging Technologies Study Section[EBIT]


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Clinical Research;Clinical Trials and Supportive Activities;Congenital Structural Anomalies;Digestive Diseases;Genetics;Human Genome;Liver Disease;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Rare Diseases

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

PHR: PROJECT NARRATIVE We propose to remain a member of the Childhood Liver Disease Research Network (ChiLDReN) and to be a key contributor to the strong research infrastructure that enables translational science and clinical trials in children with biliary atresia, cholestatic syndromes, mitochondrial hepatopathies, and primary sclerosing cholangitis. We propose to investigate the role of the TNF superfamily member TWEAK in progression of biliary fibrosis and to determine the short-term efficacy and safety of treatment with systemic FXR agonist in pediatric PSC. We will establish a Translational Science Coordination Center to support ChiLDreN sites with induced pluripotent stem cell derived disease models.

PI_NAMEs: MIETHKE, ALEXANDER  (contact)

PROJECT_TERMS: Agonist;Alagille Syndrome;Ancillary Study;Autoimmune;Bile Acids;bile duct;Biliary;Biliary Atresia;Bioinformatics;Biological Markers;Biological Models;biomarker discovery;Biopsy;Blood Cells;Caring;Child;Child Care;Childhood;cholangiocyte;Cholestasis;chronic liver disease;Clinical;clinical center;Clinical Protocols;Clinical Research;clinical translation;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Collection;Cryopreservation;Data;Data Analyses;Data Coordinating Center;data submission;database of Genotypes and Phenotypes;design;Development;Diagnostic;Disease;disease model;DNA;Enrollment;exome sequencing;experience;Family;Fibrosis;Freezing;Functional disorder;Funding;Genes;Genetic;genomic data;Genotype;Goals;Grant;Health;HMGB Family Gene;Immune;Immunobiology;improved;improved outcome;induced pluripotent stem cell;Infrastructure;Injury;innovation;interest;Intrahepatic Cholestasis;Investigation;Lead;Leadership;Libraries;Ligands;Liver;Liver diseases;Liver Fibrosis;liver stiffness;Logic;Magnetic Resonance Imaging;Manuscripts;Mediating;member;Mission;Mitochondria;Morphology;multiple omics;National Institute of Diabetes and Digestive and Kidney Diseases;Observational Study;Outcome;Paper;Pathogenesis;patient derived induced pluripotent stem cells;patient engagement;Patients;Phenotype;Plasma;Portal Hypertension;Positioning Attribute;primary sclerosing cholangitis;prospective;Prospective Studies;protein biomarkers;Proteomics;protocol development;Protocols documentation;Publications;Regulatory T-Lymphocyte;repaired;Research;Research Infrastructure;Research Personnel;Research Proposals;response;RNA;RNA purification;Role;Safety;Sampling;Science;Serum Proteins;Services;single cell genomics;Site;stem cell model;support network;surgery outcome;synergism;Techniques;Technology;Tissue Sample;Tissues;TNF gene;transcriptome;transcriptomics;Translational Research;translational study;U-Series Cooperative Agreements;Visit;Work;Yin

PROJECT_TITLE: Clinical Center for Cholestatic Liver Disease in Children


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Pediatric;Prevention;Screening and Brief Intervention for Substance Misuse;Social Determinants of Health;Substance Misuse;Women's Health Research

ORG_CITY: NEW YORK

ORG_NAME: PARTNERSHIP TO END ADDICTION

ORG_STATE: NY

PHR: Project Narrative Heavy episodic drinking (HED) in the early postpartum period is a critical public health problem that can interfere with a mother’s ability to care for her baby, and is associated with increased risk for child abuse and neglect and poor long-term child health and developmental outcomes. Postpartum mothers are often not connected to formal service systems, and often do not receive needed help for HED due to the stigma associated with substance use in mothers and fears of child protective services involvement if they disclose alcohol use to a professional. The proposed R34 will develop and test an innovative approach to reaching postpartum mothers to address HED that combines synchronous and asynchronous texting with a professional with automated messaging to deliver evidence-based brief interventions through an existing helpline.

PI_NAMEs: DAUBER, SARAH E. (contact)

PROGRAM_OFFICER_NAME: WHITAKER, DAMIYA EVE

PROJECT_TERMS: addiction;Address;Age;Alcohol consumption;automated text message;behavior change;binge drinking;brief alcohol intervention;brief intervention;Characteristics;ChatGPT;Child;Child Abuse and Neglect;Child Health;child protective service;Client;Coping Skills;cost effective;Data;design;Development;digital;Distal;drinking;effective therapy;Evaluation;evidence base;Excision;Family;Family member;family support;Feedback;Fetal Alcohol Spectrum Disorder;Focus Groups;Frequencies;Fright;Future;Goals;high risk;implementation barriers;implementation facilitators;Individual;Infant Care;Informal Social Control;Infrastructure;innovation;Intervention;intervention delivery;intervention effect;Interview;Investments;Link;Maternal and Child Health;Methods;Monitor;Mothers;Motivation;motivational enhancement therapy;multiphase optimization strategy;Outcome;Participant;perinatal mental health;Population;postpartum care;Postpartum Period;Pregnancy;prepregnancy;prevent;Process;Protocols documentation;psychoeducation;Psychological reinforcement;Public Health;Randomized;reproductive;Research;Resources;Risk;Sampling;satisfaction;Schedule;Self Efficacy;Services;skills training;smoking cessation;social stigma;Specialist;substance use;synchronous contact;System;Techniques;Telephone;Testing;Text;Text Messaging;text messaging intervention;therapy development;Time;Training;uptake;user centered design;Woman;Women's prevalence

PROJECT_TITLE: Helpline Delivery of Brief Interventions for Postpartum Heavy Episodic Drinking

STUDY_SECTION: AA

STUDY_SECTION_NAME: Clinical, Treatment and Health Services Research Study Section[AA-3]


ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: PUBLIC HEALTH RELEVANCE Sepsis affects millions and kills hundreds of thousands of Americans annually. Currently, no therapy exists to stabilize the deleterious response of the host to invasive infection. In this application, we propose to conduct research on a molecular pathway that appears to be highly promising for enabling clinicians to individualize treatment decisions in the intensive care unit. This project proposes new ways of understanding genetic risk factors in the Tie2 pathway and their influence on the wide spectrum of sepsis manifestations in order to move our community closer to the promise of personalized medicine in the intensive care unit.

PI_NAMEs: PARIKH, SAMIR M (contact)

PROGRAM_OFFICER_NAME: GOLDBERG, ILANA GRACE

PROJECT_TERMS: Acute Respiratory Distress Syndrome;adverse outcome;Affect;American;Angiopoietin-2;Angiopoietins;antagonist;Blood Vessels;Caring;Cessation of life;Collaborations;Communities;Critical Illness;Elements;Endothelium;Extravasation;Functional disorder;Gene Expression;Genetic Determinism;genetic epidemiology;Genetic Polymorphism;genetic risk factor;Genome engineering;Hemostatic function;Human;humanized mouse;Immune response;Individual;individualized medicine;Infection;Intensive Care;Intensive Care Units;Ligands;Measures;Metabolic;Metabolism;Microcirculation;Modeling;Molecular;mouse model;National Heart, Lung, and Blood Institute;Organ;Pathway interactions;Patient Care;Peripheral;personalized medicine;Physiological;Positioning Attribute;public health relevance;Qualifying;Research;response;risk prediction;Sepsis;Stress;TEK gene;Thrombosis;TIE-2 Receptor

PROJECT_TITLE: Tie2-driven vascular control in critical illness


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Dental, Oral, and Craniofacial Disease;Genetics;Human Genome;Neuroblastoma;Neurosciences;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

PHR: NARRATIVE Targeting tissue-specific genes is a challenging task due to their critical role in maintaining tissue homeostasis and physiology, but it can also offer an opportunity to achieve effective and safer therapeutic interventions. We propose to discern tissue-specific genes functionality and targetability in dieases by assessing their utility in biological networks. Thus, the purpose of this proposal is to increase the clinical utility of NIH Common Funds datasets by constructing a Common Fund Gene Utility Compendium and facilitate the discovery of druggable tissue-specific genes.

PI_NAMEs: LI, HU  (contact)

PROGRAM_OFFICER_NAME: PAPANICOLAOU, GEORGE

PROJECT_TERMS: 17q;Address;Adult;Alzheimer's Disease;arm;Benchmarking;Biological;Blood;Brain;Candidate Disease Gene;Cells;Cephalic;Chromosome abnormality;Chromosome Pairing;Clinical;Complex;Data;data library;Data Set;Development;differential expression;Disease;drug candidate;drug discovery;Drug Targeting;Etiology;Exhibits;fitness;Funding;Gene Expression;Gene Expression Profile;Genes;Genetic;Genome;Genomics;Genotype;Goals;Homeostasis;innovation;Karyotype;Libraries;Liver;Malignant Childhood Neoplasm;Malignant neoplasm of liver;Malignant Neoplasms;Maps;Modeling;Network-based;Neuroblastoma;non-alcoholic fatty liver disease;Normal tissue morphology;novel therapeutics;Organ;Pathogenesis;Pathologic;Pediatric Neoplasm;Physiology;Play;predictive modeling;Prognosis;Property;protein protein interaction;Proteins;prototype;Regulation;Research;Resources;response;Risk;Role;Shapes;side effect;Signal Pathway;Signal Transduction;Site;Solid Neoplasm;Somatic Mutation;Systems Biology;Testing;The Cancer Genome Atlas;Therapeutic;Therapeutic Intervention;Tissue-Specific Gene Expression;Tissues;United States National Institutes of Health;Visualization

PROJECT_TITLE: Common Fund Gene Utility Compendium: A Systems Biology Resource to Explore Tissue-Specific Functional Genes and Druggable Genomes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IVBH-A (50)]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Project Narrative  The goal of this project is to develop an open-source electromagnetic simulation suite for radiofrequency coil design and modeling in magnetic resonance imaging (MRI). Novel computational electromagnetics methods will be developed and combined with optimization routines and tensor decompositions to allow efﬁcient simula- tions of realistic MRI setups for brain and body imaging at any operating frequency. The proposed suite will be used for the rational design, optimization, assessment, and construction of a novel coil array for prostate imaging at 7T MRI.

PI_NAMEs: GIANNAKOPOULOS, ILIAS  (contact)

PROGRAM_OFFICER_NAME: GATLIN, TINA L

PROJECT_TERMS: absorption;Acceleration;Address;Adoption;Amplifiers;Anatomy;Award;Biological;Biomedical Engineering;biomedical imaging;Brain imaging;career;career development;Cell Nucleus;Clinic;Clinical;Complex;Computer software;cost;Deposition;design;Deterioration;Development;Development Plans;Diagnosis;Diagnostic;Dimensions;Disease;disease diagnosis;Dropout;Electromagnetic Fields;Electromagnetics;Evaluation;experimental study;Exposure to;Faculty;Fourier Transform;Frequencies;Goals;Head;Human;Image;in vivo;innovation;Integral Equation;interdisciplinary collaboration;Least-Squares Analysis;Licensing;magnetic field;Magnetic Resonance;Magnetic Resonance Imaging;Malignant Neoplasms;Maps;Measures;member;Memory;Mentors;Methods;Modeling;models and simulation;Noise;novel;open source;Organ;particle;Pathway interactions;patient safety;Pattern;Performance;Positioning Attribute;Process;Prostate;prototype;radio frequency;radiologist;Radiology Specialty;rational design;Research Personnel;Resolution;Running;Sampling;Signal Transduction;simulation;simulation software;Software Tools;spatiotemporal;Speed;Structure;Supervision;Surface;systems of equations;terabyte;Thinness;Time;Tissues;tool;Training;transmission process;Validation;Writing

PROJECT_TITLE: Open-Source Software Tools for Rapid Radiofrequency Coil Modeling and Simulation in MRI

STUDY_SECTION_NAME: Special Emphasis Panel[ZEB1 OSR-E (M1)]


NIH_SPENDING_CATS: Genetics;Human Genome;Neurosciences;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine

ORG_DEPT: NEUROSCIENCES

PHR: 5-HT neurons in the CNS have an atypical capacity for axonal regrowth after injury. In this proposed work, I will study the molecular, transcriptomic, and chromatin mechanisms for 5HT regeneration, which should lead to a deeper understating of axon regeneration mechanism and a new trigger to invest clinical approach.

PI_NAMEs: TABUCHI, NOBUKO  (contact)

PROGRAM_OFFICER_NAME: AWWAD, HIBAH OMAR

PROJECT_TERMS: Address;Adult;Architecture;ATAC-seq;Axon;axon growth;axon injury;axon regeneration;Behavior;Biochemistry;Bioinformatics;Brain Injuries;career;career development;Cell Nucleus;cell type;Central Nervous System;Chemical Injury;Chromatin;chromatin immunoprecipitation;chromatin remodeling;Cleavage Under Targets and Release Using Nuclease;Clinical;Cre-LoxP;Cytoskeleton;Data Set;Development;Development Plans;Failure;field study;Genetic;Genetic Recombination;Genetic Transcription;Goals;Growth;histone modification;in vivo;inducible Cre;injured;Injury;insight;Investments;Label;Lifelong disability;Maintenance;Methods;Molecular;Morphology;Mus;Natural regeneration;Nervous System;neuroimaging;neuron regeneration;Neurons;novel therapeutics;p-Chloroamphetamine;Peripheral Nervous System;programs;Protocols documentation;Recovery;Regulation;repaired;Research;Research Personnel;RNA analysis;Saline;Scientist;Serotonin;skills;superresolution microscopy;Synapses;synaptogenesis;System;Tamoxifen;Techniques;Testing;Therapeutic;therapeutic development;Time;tool;Training;transcription factor;transcriptome;transcriptome sequencing;transcriptomics;Work

PROJECT_TITLE: Intrinsic transcriptional programs for regeneration of serotonergicconnectivity

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-2 Study Section [NST-2]


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Networking and Information Technology R&D (NITRD);Opioid Misuse and Addiction;Opioids;Rural Health;Substance Misuse;Telehealth

ORG_DEPT: ADMINISTRATION

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: PROJECT NARRATIVE: Many people with opioid use disorder have great difficulty accessing treatment, and telemedicine for opioid use disorder (“tele-OUD”) is one potential solution. The federal government, states, and health plans have implemented new policies to encourage greater tele-OUD use. In this renewal, we seek to address several key scientific questions on the changing role of tele-OUD and how tele-OUD can help to address the rising death toll from OUD.

PI_NAMEs: HUSKAMP, HAIDEN A. (contact);MEHROTRA, ATEEV

PROGRAM_OFFICER_NAME: FITZ-RANDOLPH, MARCY ESTHER

PROJECT_TERMS: Acceleration;Address;Adult;Advocate;Affect;American;Buprenorphine;Caring;Cessation of life;Characteristics;Clinical;Communities;Data;Data Sources;Death Rate;Disparity;Environment;Epidemic;Ethnic Population;Evidence based treatment;experience;Federal Government;Future;Grant;Growth;Guidelines;health plan;Health Services Accessibility;Hybrids;Improve Access;Individual;Inferior;Insurance;Knowledge;Medicaid;Medicare;medication for opioid use disorder;Methadone;Modality;Modeling;Naltrexone;neglect;opioid epidemic;opioid mortality;opioid use disorder;Outcome;pandemic disease;patient population;Patient-Focused Outcomes;Patients;Pattern;Patterns of Care;payment;Persons;Pharmaceutical Preparations;Pharmacy facility;Policies;Policy Maker;Population;Privatization;Provider;Publications;Publishing;Quality of Care;racial population;Regulation;Research;Role;Rural;rural area;Substance Use Disorder;Telemedicine;Telephone;time use;trend;Uncertainty;video visit;virtual;virtual model;Visit

PROJECT_TITLE: Telemedicine for Treatment of Opioid Use Disorder

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 LXF-E (M1)]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Data Science;Genetics;Human Genome;Pediatric;Social Determinants of Health

ORG_NAME: RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK

PHR: NOFO: RFA-HG-23-002 Title: Developing an Innovative Genomic Data Science Curriculum: Interdisciplinary Modules for Undergraduate Education Project Narrative This project will increase participation in genomic data science research by community college Black and Latino/a/x students, who are historically underrepresented in this field. The hallmark of this project is that students will be able to contribute to the field of health disparities while learning highly marketable skills in genomic data science, including R coding and cloud computing, while building their knowledge in genomics. Ultimately, this project gives students a real-life, multidisciplinary lens through which to find their fit in contributing to better health outcomes for the communities in which they live and work.

PI_NAMEs: FULLER, KARLA  (contact)

PROGRAM_OFFICER_NAME: SEN, SHURJO KUMAR

PROJECT_TERMS: Address;Ally;Assistantship;Associate Degree;Awareness;Bachelor's Degree;biological research;Biological Sciences;Biology;Black race;Cloud Computing;Code;cohort;Collaborations;college;Communities;community college;community engagement;Community Networks;computing resources;cost;course sequence;curriculum development;Data;Data Science;Data Set;education pathway;Education Projects;Educational Curriculum;experience;Exposure to;Future;Genetic;Genetic study;genomic data;Genomics;Goals;Growth;Health;health disparity;improved;Industry;Informatics;Infrastructure;innovation;Instruction;Interdisciplinary Study;Knowledge;Latina;Latino;Latinx;Lead;Leadership;Learning;lens;Life;Modeling;multidisciplinary;Outcome;Participant;Pathway interactions;peer;peer coaching;programs;Publications;R programming language;Research;Research Personnel;Research Project Grants;Research Support;Resources;Signal Transduction;skills;social health determinants;Sorting;statistics;student mentoring;Students;success;symposium;Teacher Professional Development;Technology;tool;undergraduate education;undergraduate research experience;undergraduate student;Underrepresented Students;university student;Work

STUDY_SECTION_NAME: Special Emphasis Panel[ZHG1 HGR-M (M1)]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Childhood Leukemia;Clinical Research;Gene Therapy;Genetics;Hematology;Immunotherapy;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE Despite optimization of intensive multi-agent chemotherapy regimens, infants with B-cell acute lymphoblastic leukemia (ALL), most often characterized by chromosomal rearrangements involving KMT2A (KMT2A-R), have aggressive disease and dismal outcomes. Chimeric antigen receptor T cells targeting CD19 (CD19CART) have demonstrated unprecedented efficacy in children with relapsed or refractory pediatric ALL; however, many CD19CART-treated patients will experience ALL relapse after initial response. This study aims to improve immunotherapeutic treatment of KMT2A-R ALL by investigating rational combinatorial therapeutic approaches with CD19CART and small molecule inhibitors that target key biologic vulnerabilities of this high-risk pediatric leukemia subtype.

PI_NAMEs: NISWANDER, LISA MADALEN (contact)

PROGRAM_OFFICER_NAME: BIAN, YANSONG

PROJECT_TERMS: Acute leukemia;acute lymphoblastic leukemia cell;Acute Lymphocytic Leukemia;Adaptor Signaling Protein;Advisory Committees;antileukemic activity;Apoptosis;Award;B-Cell Acute Lymphoblastic Leukemia;bench-to-bedside translation;Binding;Biological;Biology;CAR T cell therapy;career;career development;Career Mobility;CD19 gene;Cell Physiology;Cells;Cellular biology;chemotherapy;Chemotherapy-Oncologic Procedure;Child;Childhood Acute Lymphocytic Leukemia;Childhood Leukemia;chimeric antigen receptor;chimeric antigen receptor T cells;Chimeric Proteins;Chromosomal Rearrangement;Clinical;clinical translation;Clinical Trials Design;combinatorial;Combined Modality Therapy;Communication;Complex;CRISPR/Cas technology;Data;design;Development;Disease;Disease remission;Doctor of Philosophy;early phase clinical trial;Engineering;Environment;Epigenetic Process;experience;Funding;Future;Gene Expression;Genes;Goals;high risk;Histone-Lysine N-Methyltransferase;Human;Immunobiology;Immunophenotyping;Immunotherapeutic agent;Immunotherapy;improved;improved outcome;In Vitro;in vivo;in vivo evaluation;Infant;inhibitor;innovation;instructor;Investigation;K-Series Research Career Programs;Lead;Leadership;leukemia;leukemia relapse;Leukemic Cell;leukemogenesis;Ligands;Longevity;MEK inhibition;MEKs;Menin;Mentors;Mentorship;MLL gene;Modeling;Molecular Target;mouse model;Mutation;mutational status;Outcome;Pathway interactions;patient derived xenograft model;Patients;Pediatric Hospitals;Pediatric Oncologist;Pediatrics;Pennsylvania;pharmacologic;Phenotype;Philadelphia;Physicians;Pilot Projects;pre-clinical;Pre-Clinical Model;preclinical development;Prognosis;programs;Proliferating;protein complex;Ras Signaling Pathway;Refractory;Regimen;Relapse;Remission Induction;Research;Research Personnel;Resources;response;Role;Sampling;Scientist;Senior Scientist;Signal Transduction;single-cell RNA sequencing;small molecule;small molecule inhibitor;T memory cell;T-Cell Activation;T-Cell Development;T-Cell Receptor;T-Lymphocyte;targeted treatment;Testing;Therapeutic;Training;transcriptome;transcriptomics;Treatment Efficacy;United States National Institutes of Health;Universities

PROJECT_TITLE: Leveraging small molecule inhibitors to improve CD19 CAR T cell immunotherapy for KMT2A-rearranged ALL

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


NIH_SPENDING_CATS: Arthritis;Chronic Pain;Dental, Oral, and Craniofacial Disease;Genetics;Osteoarthritis;Pain Research;Temporomandibular Muscle/Joint Disorder (TMJD)

PHR: Narrative TMJ diseases affect approximately 10% of adults in the United States alone. Osteophytes, referred to as fibrocartilage-capped bony spurs, are one of the radiographic hallmarks of TMJ degenerative disease, causing skeletal deformities, chronic pain, and limited condylar movement. This project aims to clarify further the mechanisms of osteophyte pathogenesis and to test specific therapeutic treatments to prevent the formation of TMJ osteophytes.

PI_NAMEs: KOYAMA, EIKI  (contact)

PROGRAM_OFFICER_NAME: WAN, JASON

PROJECT_TERMS: Ablation;Adhesives;Adult;Affect;antagonist;Arthralgia;arthropathies;Basic Science;Biological Availability;Biology;bone morphogenetic protein receptors;Bone Morphogenetic Proteins;Bone Spur;Cartilage;Cell Separation;Cell surface;Characteristics;Chondrogenesis;chronic pain;Clinical;clinically relevant;Complex;Data;Deformity;Degenerative polyarthritis;Development;Disease;Down-Regulation;Drops;effective therapy;efficacy testing;Environment;Enzymes;Etiology;Exhibits;EXT1 gene;extracellular;Fibrocartilages;Fracture;Genes;Glenoid structure;glycosyltransferase;Growth;heparanase;Heparitin Sulfate;Heterozygote;Hyperplasia;insight;jaw movement;joint destruction;joint function;Joints;Knockout Mice;Lead;loss of function;LoxP-flanked allele;Lubrication;lubricin;Mandibular Condyle;Mastication;Mechanics;Medial;Movement;Mus;Musculoskeletal Diseases;mutant;Mutant Strains Mice;Mutation;novel;Operative Surgical Procedures;Partner in relationship;Pathogenesis;Pathogenicity;Patients;Pharmacotherapy;Phenotype;Physiologic Ossification;Predisposition;prevent;Process;progenitor;Proteins;Proteoglycan;Quality of life;radiological imaging;Reporting;Signal Pathway;Signaling Protein;single-cell RNA sequencing;skeletal;Speech;Structure;subchondral bone;Surface;Synovial joint;Temporomandibular Joint;Temporomandibular Joint Disorders;Temporomandibular joint osteoarthritis;Testing;Therapeutic;Therapeutic Intervention;Time;Tissues;trait;translational medicine;United States

PROJECT_TITLE: Pathogenic mechanisms of TMJ osteophyte formation

STUDY_SECTION: SBSR

STUDY_SECTION_NAME: Skeletal Biology Structure and Regeneration Study Section[SBSR]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Suicide;Suicide Prevention

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Suicide among Black preteens has reached epidemic proportions and is a tremendous public health concern. Here, we propose to study the epidemiology and course of preteen suicidal ideation and behaviors (SIB), as well as individual-specific and contextual risk and protective factors associated with this course, over 4 years in a sample of ~ 1,000 urban, economically disadvantaged Black youth. Findings from the current study may inform etiological models of SIB in this vulnerable population and yield actionable knowledge regarding developmentally- and culturally relevant intervention targets to curb SIB among Black preteens.

PI_NAMEs: IALONGO, NICHOLAS S (contact);LINDSEY, MICHAEL A.;RABINOWITZ, JILL ALEXANDRA

PROGRAM_OFFICER_NAME: MURPHY, ERIC ROUSSEAU

PROJECT_TERMS: Address;Adolescent;Age;Attention;Black race;Characteristics;Child;Clinical;Communication;Conflict (Psychology);coping;Data Collection;Development;Developmental Process;Discrimination;Distal;early adolescence;economic disparity;elementary school;emotion regulation;Environment;Environmental Risk Factor;Epidemic;Epidemiology;epidemiology study;Ethnic Population;Etiology;Event;experience;falls;family support;Feeling suicidal;Heterogeneity;Individual;Intervention;Intervention Trial;Interview;Knowledge;Life;Longitudinal Studies;Low income;Mental disorders;Mental Health;Methods;minority health;minority health disparity;Modeling;modifiable risk;multimodality;neighborhood disadvantage;Neighborhoods;Parent-Child Relations;Patient Self-Report;Pilot Projects;Policies;Population;population based;Positioning Attribute;preadolescence;Prevention;preventive intervention;Probability Samples;Problem Solving;Process;protective factors;Psychopathology;Public Health;racial discrimination;racial population;Randomized;Recording of previous events;Reporting;Research;response;Risk;Risk Factors;Sample Size;Sampling;Schools;Selection Bias;Severities;social;Social Environment;social health determinants;Social Problems;socioeconomic disadvantage;Structural Racism;Students;study population;suicidal adolescent;suicidal behavior;suicidal risk;Suicide;Suicide attempt;suicide model;Suicide prevention;suicide rate;Time;Underrepresented Populations;universal prevention;Urban Population;Vulnerable Populations;Work;Youth

PROJECT_TITLE: Investigating Suicide Risk and Protective Factors among Economically Disadvantaged, Preteen Black Youth

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-E (05)]


ORG_CITY: KANSAS CITY

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: Project Narrative This project will identify patient-prioritized, equity-informative measures of health care quality in primary care and incorporate them into existing quality improvement (QI) dashboards. Furthermore, identified priority measures will inform the community-engaged design of interventions to decrease racial and ethnic health inequity. The goal is to generate QI metrics meaningful to both patients and providers useful to inform and measure health equity improvement strategies in primary care.

PI_NAMEs: BRIDGES, KRISTINA  (contact)

PROGRAM_OFFICER_NAME: WILLIS, TAMARA

PROJECT_TITLE: A patient-informed approach to measuring and mitigating inequity in primary care


ORG_CITY: WASHINGTON

ORG_NAME: CHILDREN'S RESEARCH INSTITUTE

ORG_STATE: DC

PHR: NARRATIVE: The lack of validated pediatric risk prediction tools for emergency medical services (EMS) is a significant problem, resulting in under-triage (where children with urgent medical needs are left at the scene) and over-triage (where children with no urgent resource needs are taken by ambulance to an emergency department). This mentored career development award seeks to address this problem by identifying patient factors associated with under-triage, then refining and pilot testing the Pediatric Observation Priority Score (POPS) for use in EMS agencies. Validating a pediatric risk prediction tool for EMS use would enable EMS agencies to develop evidence-based and patient-centered alternative dispositions (including treatment in place) that are safe and efficient.

PI_NAMEs: WARD, CALEB  (contact)

PROGRAM_OFFICER_NAME: CHANLONGBUTRA, AMORNRAT

PROJECT_TITLE: Improving risk prediction for children seeking emergency medical services (EMS) care with non-emergent complaints


NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Data Science;Emergency Care;Heart Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Precision Medicine

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative (Public Health Relevance): A promising strategy to improve survival from out-of- hospital cardiac arrest (OHCA) – a major cause of death in the US and around the world – is to advance beyond our current “one-size-fits-all” resuscitation protocol governing administration of shock, cardiopulmonary resuscitation (CPR), and medication treatments, and to instead align treatment with the dynamic and heterogeneous physiology that characterizes OHCA. This proposal seeks to advance such a strategy of precision medicine by applying deep learning (data-driven artificial intelligence) methods to analyze the real-time OHCA electrocardiogram during CPR and determine the patient’s time-sensitive physiology, estimate the physiologic effects of treatment, and evaluate the clinical implications of these algorithms which predict mechanistic (return of organized rhythm) and clinical (spontaneous pulse and survival) outcomes. Taken together, the research has the potential to transform OHCA resuscitation from a static, fixed approach to a dynamic, individualized strategy that leverages real-time understanding of patient physiology to guide treatment and ultimately improve OHCA outcome.

PI_NAMEs: COULT, JASON  (contact)

PROGRAM_OFFICER_NAME: COADY, SEAN

PROJECT_TERMS: Algorithms;Animals;Anti-Arrhythmia Agents;Architecture;Arrhythmia;Artificial Intelligence;artificial intelligence algorithm;Biomedical Engineering;Biometry;Cardiac;Cardiac Electrophysiologic Techniques;Cardiopulmonary Resuscitation;career;career development;Caring;Cause of Death;Circulation;Classification;Clinical;clinical diagnostics;clinical predictors;clinically relevant;cohort;convolutional neural network;Custom;Data;data resource;Data Set;deep learning;deep learning model;Defibrillators;design;Development;Doctor of Philosophy;Dose;education planning;Electric Countershock;Electrocardiogram;Emergency medical service;Evaluation;experience;Failure;Fostering;Foundations;Funding;Future;Goals;Guidelines;Heart Arrest;heart rhythm;Heterogeneity;Hospitals;Human;improved;improved outcome;individual patient;Interruption;Intervention;Investigation;Knowledge;Learning;Link;long short term memory;Lung;Machine Learning;machine learning method;Measures;Mechanics;Medicine;Mentors;Mentorship;Methods;Modeling;Morphologic artifacts;Morphology;mortality;multidisciplinary;multimodal modeling;novel;out-of-hospital cardiac arrest;Outcome;Output;Patients;Performance;personalized strategies;Pharmaceutical Preparations;Phenotype;Physiologic pulse;Physiological;Physiology;Positioning Attribute;precision medicine;prevent;Probability;Productivity;professor;prognostic;prospective;Protocols documentation;public health relevance;Recurrence;Refractory;Research;Research Assistant;Research Personnel;response;Resuscitation;Scientist;Shock;signal processing;Signal Transduction;skills;success;Technical Expertise;Techniques;Technology;Time;Training;treatment effect;Universities;Vasoconstrictor Agents;vector;Ventricular Fibrillation;Vital Status;Vocational Guidance;Washington;Work

PROJECT_TITLE: Artificial Intelligence to Improve Resuscitation following Out-of-Hospital Cardiac Arrest

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS (MA)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Contraception/Reproduction;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Suicide;Suicide Prevention;Violence Against Women;Violence Research;Women's Health Research;Youth Violence

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative  Suicide is the second leading cause of death in youth aged 10-12, with recent years showing a rise in suicidal thoughts and behaviors, particularly in girls. This research represents one of the initial efforts to identify risk trajectories and mechanisms specific to preteen suicide in girls. Findings will aid in linking distal risk factors such as childhood threat exposure (i.e., abuse) and potential proximal risk factors including maladaptive social motivation and advanced pubertal timing to inform developmental pathways to suicide risk.

PI_NAMEs: BALDELLI, ANDREA PELLETIER (contact);MILLER, ADAM BRYANT

PROJECT_TERMS: acceptability and feasibility;Adolescent;Adult;Age;aged;assigned female at birth;Behavior assessment;Biological;Biological Assay;boys;Caregivers;Cause of Death;Child;Childhood;childhood adversity;cognitive process;Collaborations;Communities;Data;Data Collection;Development;Distal;early childhood;Early identification;Early Intervention;Ecological momentary assessment;Enrollment;ethnic diversity;ethnic minority;Ethnic Population;experience;Exposure to;Failure;Feedback;Feeling suicidal;Female Adolescents;Funding;girls;Goals;Hormonal;Hormones;improved;Information Dissemination;Interpersonal Violence;Interview;Investigation;Knowledge;life span;Link;Lived experience;Measures;Mediating;Mental disorders;minority children;Modeling;Motivation;National Institute of Mental Health;non-suicidal self injury;novel;Pathway interactions;Patient Self-Report;peer;preadolescence;prevent;preventive intervention;Process;programs;prospective;Psychopathology;pubertal timing;Puberty;puberty transition;Questionnaires;racial diversity;racial minority;racial population;Research;Research Proposals;response;Risk;Risk Behaviors;Risk Factors;Role;Saliva;Sampling;social;social engagement;social influence;Social Interaction;stressor;suicidal behavior;suicidal morbidity;suicidal risk;Suicide;Suicide attempt;Suicide prevention;suicide rate;Teenagers;Testing;theories;Time;United States National Institutes of Health;Visit;Work;Youth

PROJECT_TITLE: Peripubertal Social Motivation as a Novel Risk Factor Linking Childhood Threat Exposure and Suicidal Ideation and Behavior in Preteen Girls.


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: LA JOLLA

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

PHR: The NLRP3 inflammasome is a key regulator of immune responses to pathogens but also contributes to inflammatory pathology in many chronic diseases. This proposal seeks to elucidate key aspects of inflammasome assembly and regulation. It is hoped that the insights provided will lead to new therapeutic approaches for treating chronic inflammatory diseases.

PI_NAMEs: REED, STEVEN I (contact)

PROGRAM_OFFICER_NAME: SINGLETON, KENTNER L

PROJECT_TERMS: Anabolism;Binding;Binding Sites;Biological;Biological Response Modifiers;Biology;C-terminal;CASP1 gene;Cells;Chronic Disease;chronic inflammatory disease;Complex;conformational conversion;Consensus;Cryoelectron Microscopy;cytokine;Dependence;Disease;Distress;Electrons;Event;FBXW7 gene;Genetic Transcription;Human;IL18 gene;Immune response;Immunoprecipitation;In Vitro;Infection;Inflammasome;Inflammatory;Inflammatory Response;insight;Interleukin-1 beta;Investigation;Ligase;Link;Lysine;Macrophage;Maps;Mediating;migration;Modeling;Modification;Molecular Conformation;monomer;mutant;Mutate;N-terminal;Neurodegenerative Disorders;novel therapeutic intervention;overexpression;pathogen;Pathology;Phase;Phosphorylation;Polyubiquitin;prevent;Process;Proteins;recruit;Regulation;Research;response;Role;Saccharomycetales;self assembly;Sequence Analysis;Series;Signal Transduction;Site;Stimulus;Structure;Testing;transcription factor;Transcriptional Regulation;UBA Domain;Ubiquitin;ubiquitin ligase;Ubiquitin-mediated Proteolysis Pathway;Up-Regulation

PROJECT_TITLE: Mechanistic Investigation of the Role of FBXW7 in Inflammasome Activation

STUDY_SECTION_NAME: Cellular Signaling and Regulatory Systems Study Section[CSRS]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Aphasia;Behavioral and Social Science;Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PUBLIC HEALTH RELEVANCE. Inclusions of the transactive DNA binding protein 43 (TDP-43) are present in an overwhelming majority of elderly individuals with Alzheimer's disease (AD). These co-occurring diseases lead to dementia, functional decline, and brain changes in the elderly—a population that is steadily rising worldwide. The current study will address this major public health challenge by investigating the underling neurobiological signatures and mechanistic contributions of TDP-43 in AD, with the long-term goal of contributing to the development of targeted interventions for dementia.

PI_NAMEs: GEFEN, TAMAR D (contact)

PROGRAM_OFFICER_NAME: OPANASHUK, LISA A

PROJECT_TERMS: Address;Age;Alzheimer's Disease;Anatomy;Atrophic;Autopsy;base;Behavior;Behavioral;behavioral variant frontotemporal dementia;Bilateral;biomedical referral center;Brain;Cell Death;Cellular Morphology;cerebral atrophy;Clinical;clinical heterogeneity;clinical phenotype;Cognition;cohort;Complex;Comprehension;corticobasal degeneration;Dementia;Development;Diagnosis;diagnostic tool;Disease;disease diagnosis;DNA-Binding Proteins;Elderly;Environment;Failure;Frontotemporal Lobar Degenerations;functional decline;Functional disorder;Funding;Goals;granule cell;Histologic;Human;Image;Impaired cognition;Impairment;in vivo;Individual;Inferior frontal gyrus;International;Intervention;language impairment;Lead;Left;Lobar;Magnetic Resonance Imaging;Methods;Microglia;Modeling;MRI Scans;multidisciplinary;Nerve Degeneration;Neuroanatomy;Neurobiology;Neurodegenerative Disorders;Neuroglia;Neurons;neuropathology;Neuropsychology;Outcome;Pathologic;Pathology;Patients;Pattern;Personality;Phenotype;Pick body;Pick Disease of the Brain;Population;Primary Progressive Aphasia;Progressive Aphasias;Progressive Supranuclear Palsy;protein TDP-43;Public Health;public health relevance;Regional Anatomy;regional atrophy;Semantics;Specificity;Specimen;Symptoms;Synapses;Syndrome;tau Proteins;Tauopathies;Tissues;Variant;Work

PROJECT_TITLE: Clinical, Neuroanatomic, and Pathologic Signatures of FTLD-tau in Dementia Phenotypes - Diversity Supplement (Antwan Howard)

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


NIH_SPENDING_CATS: Behavioral and Social Science;Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

ORG_CITY: SAN ANTONIO

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF TEXAS SAN ANTONIO

PHR: Project Narrative The proposed research is relevant to public health because it entails new strategies to teach computational genomics and data science to a broader community, in particular under-represented minority students. Thus, the proposed work will enhance the diversity in the genomics workforce, and advance the likelihood that underserved or health disparity populations participate in, and benefit from health research and genomic medicine.

PI_NAMEs: RUAN, JIANHUA  (contact);WANG, YUFENG

PROJECT_TERMS: academic preparation;Address;Area;base;Bioinformatics;cancer genomics;career;cloud based;Cloud Computing;Collaborations;Communities;comparative genomics;Competence;Complex;Data Science;data science education;Dependence;design;Development;Discipline;Diverse Workforce;Education;Educational Curriculum;Educational process of instructing;effectiveness evaluation;empowerment;Enrollment;Ensure;Evaluation;Evolution;Exercise;experience;Faculty;Feedback;flexibility;Gender;Genome;genome sciences;genomic data;Genomic medicine;Genomics;Graph;Health Benefit;health disparity populations;Human;Hybrids;improved;Infrastructure;Institution;Instruction;Joints;Knowledge;Learning;learning materials;Learning Module;lectures;Length;Machine Learning;Minority Groups;Minority-Serving Institution;personalized learning;Population;Positioning Attribute;Preparation;programs;Public Health;Race;Recording of previous events;Research;Resources;response;role model;Science;skills;Slide;STEM field;Strategic Planning;Structure;Students;success;Technology;Texas;Training and Education;training opportunity;Training Programs;undergraduate student;Underrepresented Minority;underrepresented minority student;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Expanding Genomic Data Science Access via Cloud Computing and Dynamic Learning Modules


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Emerging Infectious Diseases;Immunization;Infectious Diseases;Microbiome;Orphan Drug;Prevention;Rare Diseases;Vaccine Related

ORG_CITY: BURLINGTON

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE

ORG_STATE: VT

PHR: Project Narrative Critical to polio eradication efforts is development of new vaccines that stimulate effective mucosal immunity in the gut to control viral shedding and eliminate environmental reservoirs of poliovirus (PV). This project will provide critical information to better understand the immunologic and microbiologic factors impacting development of effective mucosal immunity to PV. It will also assess the effect of a novel mucosal adjuvant (dmLT) on systemic and mucosal immune responses to Inactivated Poliovirus Vaccines (IPV). The goal of these investigations is to guide future studies directed at harnessing immune-microbiota interactions to enhance mucosal immune responses to polio vaccines and other enteric pathogens.

PI_NAMEs: CROTHERS, JESSICA W. (contact)

PROGRAM_OFFICER_NAME: PARK, EUN-CHUNG

PROJECT_TERMS: Address;Adjuvant;Adult;Antibody Response;Antigen-Antibody Complex;antigen-specific T cells;Antigens;Applied Skills;Attenuated;Bioinformatics;Biological;Biological Factors;Board Certification;booster vaccine;career;Cell Wall;Clinical;Clinical Data;Clinical Research;Clinical Trials;Collaborations;college;Communicable Diseases;Communities;Computational Technique;Computer Models;Computing Methodologies;Data;Data Analyses;data integration;design;Development;Disease;Enteral;enteric infection;enteric pathogen;Environment;Environmental Risk Factor;Evaluation;Failure;Feces;Flow Cytometry;Funding;Future;Gastrointestinal tract structure;Goals;gut microbiome;gut microbiota;Human;Human Microbiome;Human poliovirus;Immune;Immune response;Immune Targeting;Immunologics;Immunology;Infection;Infectious Diseases Research;Innate Immune Response;insight;Intervention;Investigation;K-Series Research Career Programs;Knowledge;Learning;Machine Learning;Mentors;Metabolic Pathway;metagenomic sequencing;Microbiology;microbiome;microbiome analysis;microbiota;Mucosal Immune Responses;Mucosal Immunity;mucosal vaccine;Mucous Membrane;National Institute of Allergy and Infectious Disease;neurovirulence;novel;novel vaccines;Oral Poliovirus Vaccine;Outcome;Outcome Measure;Paralysed;Physicians;Poliomyelitis;Poliovirus Vaccines;Positioning Attribute;practical application;prevent;Prevention;Research;research clinical testing;Research Technics;Research Training;Role;Scientist;Shotguns;Site;skills;Specimen;Strategic Planning;Structure;T cell response;Techniques;Testing;Training;Translational Research;transmission process;Universities;Vaccinated;Vaccine Adjuvant;Vaccine Clinical Trial;vaccine evaluation;vaccine immunogenicity;Vaccine Research;vaccine response;vaccine strategy;vaccine trial;Vaccinee;Vaccines;vaccinology;Vermont;Viral;Viral reservoir;viral transmission;Virus;Virus Diseases;Virus Replication;Virus Shedding;Work;World Health Organization

PROJECT_TITLE: Understanding the Development of Mucosal Immunity to Poliovirus: Adjuvants and Modulation of the Enteric Microbiota

STUDY_SECTION: AITC

STUDY_SECTION_NAME: Allergy, Immunology, and Transplantation Research Committee[AITC]


NIH_SPENDING_CATS: Biomedical Imaging;Cardiovascular;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Dietary Supplements;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Neurosciences;Nutrition;Obesity;Pediatric;Prevention;Social Determinants of Health

PHR: PROJECT NARRATIVE The current proposal addresses obesity and cardiometabolic disease, among the most significant modifiable risk factors for cardiovascular disease in the United States. The proposed research will provide advanced-level training of physicians by an experienced mentor and scientist, thereby producing the next generation of patient- oriented researchers to conduct high-quality studies of cardiovascular disease development and prevention in humans.

PI_NAMEs: SCHUR, ELLEN A (contact)

PROGRAM_OFFICER_NAME: PRICE, CANDICE

PROJECT_TERMS: acceptability and feasibility;Address;Adult;adult obesity;aged;Area;Automobile Driving;Award;bariatric surgery;Body Weight;Carbohydrates;Cardiometabolic Disease;cardiometabolic risk;cardiometabolism;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;Caregivers;Cell Physiology;Central Nervous System;Child;Childhood;Communities;community intervention;comorbidity;Consumption;cost;Crossover Design;Data;Databases;Development;Diabetes Mellitus;Diet;dietary;Dietary Factors;Dietary Fiber;Dietary Intervention;disorder prevention;disorder risk;Educational Status;Endocrinology;energy balance;Enrollment;experience;Exposure to;Faculty;Family;feasibility testing;feeding;Focus Groups;follow-up;Food Preferences;food quality;Fostering;Framingham Heart Study;Fructose;fruits and vegetables;Funding;Future;Gestational Diabetes;Gliosis;Glucose;Goals;good diet;Grain;Health;Health Promotion;Human;Hypothalamic structure;improved;improved outcome;infant nutrition;Inflammation;Inflammatory;Inflammatory Response;insight;Insulin Resistance;insulin sensitivity;Intake;Intervention;Intervention Studies;Investigation;life span;Link;Literature;lower income families;Magnetic Resonance Imaging;Meat;Medicine;meetings;Mentors;Mentorship;Metabolic syndrome;Methods;modifiable risk;Mus;Neurobiology;Neuroglia;Neurologic;next generation;Non-Insulin-Dependent Diabetes Mellitus;nutrition;Nutrition Policy;Obesity;obesity in children;obesity risk;obesity treatment;obesogenic;Outcome;Overweight;Participant;Pathogenesis;patient oriented;patient oriented research;Pediatrics;Physicians;pilot test;poor health outcome;Population;Poverty;pre-clinical;preference;preservation;Prevention;Prevention strategy;Preventive;Process;Productivity;professor;programs;protective effect;Qualitative Research;Radiology Specialty;Randomized;Relaxation;Research;Research Methodology;Research Personnel;response;Risk Factors;Risk Reduction;Rodent;Rodent Model;Role;Sampling;saturated fat;Schools;Scientist;skills;Stimulus;Structure of nucleus infundibularis hypothalami;sugar;Surveys;Taste Perception;Testing;Thinness;Time;Training;Translational Research;translational study;United States;Universities;Visceral fat;Washington;Weight;Weight Gain;Work

PROJECT_TITLE: Fostering patient-oriented research in cardiometabolic disease pathogenesis and prevention

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR (MA)]


NIH_SPENDING_CATS: Adolescent Sexual Activity;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse;Women's Health Research

PHR: PROJECT NARRATIVE This project provides a comprehensive study of the many social and structural factors leading to racial/ethnic differences in HIV transmission and substance use among young men who have sex with men and transgender women (YMSM-TW). Using complex social network modeling and in-depth network surveys of 2700 racially diverse YMSM-TW across five US cities, it will offer a thorough account of how structural forces shape opportunity and risk through population-level differences in connections to people and places. Strengthened by a robust plan for community engagement, this work will help produce tangible targets for public health interventions and transform understanding on drivers of disparities.

PI_NAMEs: BIRKETT, MICHELLE  (contact)

PROGRAM_OFFICER_NAME: DUNSTON, SHEBA KING

PROJECT_TERMS: Behavior;black men who have sex with men;Black race;Chicago;Cities;Collaborations;Communicable Diseases;Communities;community advisory board;community building;community engagement;community planning;Complex;Data;Disadvantaged;Disease;Disparity;Employment;Environment;ethnic difference;ethnic minority population;experience;Funding;gender minority group;Health;health disparity;health inequalities;Health Personnel;Healthcare;high risk sexual behavior;Hispanic;HIV;HIV disparities;HIV Seropositivity;Housing;illicit drug use;Individual;Inequity;Infection;innovation;Intervention;Leadership;Literature;marginalization;marginalized population;member;men who have sex with men;Meta-Analysis;Minority Groups;Modeling;network models;non-Native;novel strategies;Observational Study;open source;Outcome;Pathway interactions;Pattern;Persons;Population;Preventive;Public Health;public health intervention;Race;racial difference;racial diversity;racial minority population;Research Personnel;Resources;Risk;Risk Factors;segregation;sex;sexual minority group;Sexual Partners;Shapes;simulation;skills;social;Social Environment;social factors;Social Network;social observations;social relationships;Social status;social stigma;Social support;structural determinants;Structure;Substance abuse problem;substance use;Surveys;System;Testing;tool;transgender women;transmission process;Travel;United States National Institutes of Health;web app;Work;young men who have sex with men

PROJECT_TITLE: SILOS: Structural Inequities across Layers Of Social-Context as Drivers of HIV and Substance Use

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 TXT-E (M1)]


NIH_SPENDING_CATS: Aging;Hematology;Precision Medicine;Rare Diseases;Sickle Cell Disease

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

PHR: PROJECT NARRATIVE Sickle cell disease (SCD) results in premature aging and early mortality, with physiologic measures of aging comparable to unaffected African-American individuals 20-30 years older, and mean life expectancy of affected adults of only 58 years. We hypothesize that causes of death are related to SCD severity of accumulating organ damage and that these associations may be attributed to multi-omic risk factors. We will study multiomic markers of early mortality versus successful aging, using the data and biological samples available from our own sickle cell disease study population of ~600 individuals as well as those of other study cohorts (total >4000) deposited in the NHLBI TOPMed biodata repository.

PI_NAMEs: ASHLEY-KOCH, ALLISON E (contact);TELEN, MARILYN J

PROGRAM_OFFICER_NAME: GAO, HONGWEI

PROJECT_TERMS: Address;Adult;Affect;African American population;Age;age acceleration;Aged, 80 and over;Aging;aging biomarker;aging clocks;Animal Model;Attention;beta Globin;Biological;Biological Markers;Cardiovascular Diseases;Caring;Cause of Death;Central Nervous System;Cessation of life;Characteristics;Clinical;Clinical Data;cohort;Cohort Studies;Complex;Data;Deoxygenated Sickle Hemoglobin;Deposition;Deterioration;Disease;Disease Progression;DNA copy number;Event;Fetal Hemoglobin;follow-up;Frequencies;Functional disorder;genome sequencing;Glycopeptides;glycoproteomics;glycosylation;Goals;Haplogroup;Health;Heart;Hematopoiesis;Hematopoietic Neoplasms;Hemolysis;heteroplasmy;Immunoglobulins;improved;Individual;Inflammation Mediators;Inflammatory;Kidney;Kidney Diseases;Laboratories;Length;Leukocytes;Life Expectancy;life span;Link;Liver;Lung;machine learning method;Mass Spectrum Analysis;Measures;Metabolic;Mitochondria;Mitochondrial DNA;Modeling;Molecular;molecular marker;mortality;multiple omics;Mus;Mutation;National Heart, Lung, and Blood Institute;Nature;novel;Organ;Outcome;patient subsets;Patients;Peptides;personalized medicine;Phenotype;Physical Function;Physiological;Physiological Processes;Plasma;Plasma Proteins;polymerization;Polymers;Population;Post-Translational Protein Processing;precision medicine;predictive modeling;Premature aging syndrome;Premature Mortality;Prognosis;prognostic signature;programs;Proteins;Proteomics;rate of aging;renal damage;repository;Risk;Risk Factors;Role;Sampling;Severities;Severity of illness;Sickle Cell;Sickle Cell Anemia;study population;System;telomere;therapeutic target;Trans-Omics for Precision Medicine;whole genome;Work

PROJECT_TITLE: 'Omics predictors of Sickle Cell Severity and Survival

STUDY_SECTION: AIMR

STUDY_SECTION_NAME:
Aging, Injury, Musculoskeletal, and Rheumatologic Disorders Study
Section[AIMR]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: This proposal, focused on machine learning, citizen science, and heterogeneity within the Hispanic community, within the realm of Alzheimer disease (AD) will utilize established resources from cycle 1. We will fill critical gaps providing objective quantitative understanding of neuropathologic differences and engage the community to examine the neuropathologic landscape of AD leading to better precision medicine approaches especially for persons within the Hispanic community.

PI_NAMEs: DUGGER, BRITTANY NICOLE (contact)

PROGRAM_OFFICER_NAME: PERCY-LAURRY, ANTOINETTE LOIS

PROJECT_TERMS: Acceleration;Admixture;Adult;Age;Algorithms;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease related dementia;Amyloid;amyloid pathology;Anatomy;Area;Awareness;Brain;Brain imaging;California;citizen science;Classification;Clinical;Clinical Data;cohort;Communities;community engagement;Community Health Education;Community Outreach;Consensus;convolutional neural network;Crowding;crowdsourcing;Data;Data Set;deep learning;Deposition;Detection;Disease;Education;Education and Outreach;Equity;Ethnic Origin;Evaluation;frontal lobe;Gender;Genetic;Goals;Grain;Heterogeneity;Hispanic;Hispanic ancestry;hispanic community;Hispanic Populations;Histology;Human;human tissue;Impaired cognition;Individual;innovation;insight;Institution;Latino;Location;Machine Learning;machine learning algorithm;Manuscripts;Measurement;Measures;Methodology;Methods;multidisciplinary;Neuroanatomy;Neurofibrillary Tangles;neuropathology;Neuropil Threads;Not Hispanic or Latino;novel;pandemic disease;Paper;Parietal Lobe;Participant;Pathologic;Pathology;Patient Self-Report;Peer Review;Persons;Phenotype;Pilot Projects;precision medicine;Preparation;Publishing;Research;Resources;Sampling;Senile Plaques;Slide;Specificity;Specimen;Stains;Standardization;Statistical sensitivity;Structure;Temporal Lobe;terabyte;Testing;tool;Universities;volunteer

PROJECT_TITLE: The Neuropathologic Landscape of Alzheimer's Disease in Hispanic Decedents


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Fragile X Syndrome;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Public Health Relevance/Narrative Fragile X syndrome (FXS) is the most common inherited cause of autism spectrum disorder, and patients suffer from complex behavioral and intellectual deficits. The disease is thought to be driven by local DNA methylation of FMR1, yet we recently found Megabase-scale domains of heterochromatin encompassing long synaptic genes in FXS patient-derived cells and brain tissue. Here, using cutting-edge single-cell genomics, imaging, computational analyses, and genome engineering, we propose to dissect the cause-and-effect relationship between 3D genome misfolding, inter-chromosomal interactions, Megabase-scale heterochromatin domains, and transcriptional silencing in human models of FXS.

PI_NAMEs: PHILLIPS-CREMINS, JENNIFER ELIZABETH (contact)

PROGRAM_OFFICER_NAME: PANCHISION, DAVID M

PROJECT_TERMS: 3-Dimensional;5' Untranslated Regions;Anxiety;ASD patient;Attenuated;attenuation;autosome;Auxins;Back;Behavioral;Binding;Biological Assay;brain cell;brain tissue;Candidate Disease Gene;Cell Adhesion;Cell Line;Cell Nucleus;Cells;ChIP-seq;Chromatin;Cleavage Under Targets and Release Using Nuclease;Clinical;clinical phenotype;Clustered Regularly Interspaced Short Palindromic Repeats;cohesin;cohesion;Complex;Computer Analysis;Data;data integration;Deposition;derepression;Disease;Disease Progression;DNA;DNA Methylation;Engineering;Enzymes;Epithelium;Event;Excision;Exhibits;FMR1 gene;Fragile X Syndrome;Funding;Gene Expression;Gene Silencing;Genes;Genetic Transcription;Genome;genome editing;Genome engineering;genome wide methylation;genome-wide;Genomic Instability;Harvest;Heterochromatin;Hi-C;Histones;human model;Hybrids;Hypersensitivity;Image;Imaging technology;induced pluripotent stem cell;Inherited;insight;Intellectual functioning disability;Knockout Mice;Learning Disabilities;Length;Link;Maintenance;Maps;Mediating;Mendelian disorder;messenger ribonucleoprotein;Methylation;Methyltransferase;Microscope;Modeling;Mutation;nanopore;Neurodevelopmental Disorder;Neurons;Nucleotides;Onset of illness;patient derived induced pluripotent stem cells;Patients;pharmacologic;pluripotency;Predisposition;programs;public health relevance;Publishing;Recovery;recruit;replication stress;Repression;reproductive development;RNA;Role;Seizures;Short Tandem Repeat;Signal Transduction;single cell genomics;social anxiety;social deficits;Stimulus;Structure;Synapses;Synaptic plasticity;System;Techniques;Testing;Textbooks;Therapeutic;Time;Tissues;Transcript;Transferase;Triplet Multiple Birth;Work;X Chromosome

PROJECT_TITLE: Connecting 3D genome misfolding to transcriptional silencing in fragile X syndrome

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Clinical Research;Clinical Trials and Supportive Activities;Congenital Structural Anomalies;Digestive Diseases;Genetics;Human Genome;Liver Disease;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period

ORG_CITY: RICHMOND

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: With ongoing involvement of Atlanta Clinical Center, we will continue to contribute to the achievement of all the goals of ChiLDReN, arguably the most robust and feasible means to make a difference for children with cholestatic liver diseases ever established. Linked participation with leadership of genomics initiatives will allow ongoing discoveries into the  modifiers of clinical outcomes along with opportunities for the discovery of rational therapeutic targets.

PI_NAMEs: KARPEN, SAUL J. (contact)

PROGRAM_OFFICER_NAME: DOO, EDWARD

PROJECT_TERMS: Achievement;Age;Biliary Atresia;Black Populations;care providers;Caring;Child;Child health care;Childhood;Cholestasis;Clinical;clinical center;Clinical Research;Collaborations;Data;Data Collection;Disease;Disease Progression;Education;Enrollment;Ensure;Etiology;exome;experience;Future;Genetic;Genome;Genomics;Goals;Grant;Human Resources;improved;Infrastructure;innovation;Intervention Studies;Leadership;Link;Liver;Liver diseases;medical specialties;Modernization;Modification;novel;Observational Study;Outcome;Participant;participant retention;Patients;Population;Recording of previous events;Research;Research Infrastructure;shift work;Site;targeted treatment;Technology;therapeutic target;Work

PROJECT_TITLE: VCU-Atlanta Center for the Childhood Liver Disease Research Network (ChiLDReN)

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-Q (M1)]


NIH_SPENDING_CATS: Drug Abuse (NIDA only);Lung;Neurosciences;Opioids;Substance Misuse

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative No changes from Parent award.

PI_NAMEs: YACKLE, KEVIN  (contact)

PROGRAM_OFFICER_NAME: POLLOCK, JONATHAN D

PROJECT_TERMS: Breathing;Neurons;Opioid;Opioid Receptor;parent project;receptor expression;Ventilatory Depression

PROJECT_TITLE: Utilizing opioid receptor expression to identify the neurons and molecules responsible for opioid respiratory depression and basal breathing.


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences

ORG_CITY: FORT COLLINS

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: COLORADO STATE UNIVERSITY

ORG_STATE: CO

PHR: Project Narrative Non-learned defensive behaviors are necessary for survival, like fleeing or freezing in the face of threat. Whether these response change in response to acute and chronic stress is not currently known. Here, we will test whether stress alters behavioral responses to threats and examine the brain signals responsible for such changes.

PI_NAMEs: VAAGA, CHRISTOPHER EDWARD (contact)

PROGRAM_OFFICER_NAME: CHEN, DAOFEN

PROJECT_TERMS: Acute;acute stress;Animals;Behavior;Behavioral;behavioral habituation;Behavioral Mechanisms;behavioral response;Brain;Cerebellum;Chronic stress;Dopamine;dopaminergic neuron;Environment;experimental study;fear memory;Fiber;flexibility;Freezing;habituation;in vivo;induced pluripotent stem cell;Interneurons;Learning;Lesion;midbrain central gray substance;Motor Neurons;Mus;Nature;optogenetics;Output;Photometry;Property;response;Role;Signal Transduction;Source;Stress;Synapses;System;Testing;Work

PROJECT_TITLE: Cerebellar Modulation of Innate Defensive Behaviors


NIH_SPENDING_CATS: Autoimmune Disease;Digestive Diseases;Genetics;Human Genome;Inflammatory Bowel Disease;Prevention

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: PROJECT NARRATIVE: The genetics underlying inflammatory bowel disease are intricate, with many susceptibility loci lacking known functions. Our objective is to identify and characterize a significant portion of these loci that share a common feature. This research will assign functions to numerous susceptibility loci and predict their collective risk in specific patients, paving the way for a personalized medicine approach.

PI_NAMEs: KUO, CALVIN J;LI, JIN BILLY  (contact)

PROGRAM_OFFICER_NAME: SHEA-DONOHUE, TEREZ

PROJECT_TERMS: Accounting;adaptive immunity;ADAR1;Adenosine;Adverse event;Affect;Agreement;Alleles;Animal Disease Models;Animal Model;antagonist;Autoimmune;Autoimmune Diseases;Biology;Birth;causal variant;Cell Line;cell type;Cells;Chronic;Colitis;Colon;comparison control;Complex;CRISPR/Cas technology;Crohn's disease;Data;Defect;Disease;Disease susceptibility;disorder risk;DNA;Double-Stranded RNA;Encapsulated;Environment;Epithelial Cells;Epithelium;Etiology;Event;Exhibits;gain of function mutation;Gene Activation;Gene Expression;Genes;Genetic;genetic analysis;Genetic Predisposition to Disease;Genetic Risk;genetic variant;genome sequencing;genome wide association study;genomic locus;gut inflammation;Heritability;Human Genetics;IFIH1;Immune;Immune response;Immune signaling;Immunity;Impairment;In Vitro;in vivo;Individual;Inflammation;Inflammatory;Inflammatory Bowel Diseases;Inosine;insight;Interferon Type I;Interferon Type II;Interferons;intestinal epithelium;Intestines;knock-down;Knock-out;Knowledge;Lesion;life span;Link;loss of function;Maps;Measures;Mediating;Modeling;Mus;Natural Immunity;Nature;novel;Pathogenicity;Pathology;patient stratification;Patients;personalized medicine;pharmacologic;Plasmids;Play;polygenic risk score;Positioning Attribute;predictive modeling;Predisposition;prevent;protective allele;Proteins;Relapse;Reporter;Research;response;Retrotransposon;Risk;Risk Assessment;risk variant;RNA;RNA Editing;Role;sensor;Susceptibility Gene;System;Testing;Therapeutic;therapeutic development;Tissues;transcriptome sequencing;Ulcerative Colitis;Validation;Variant;villin;Viral;Virus Diseases;whole genome;Work

PROJECT_TITLE: Impaired cellular RNA editing as a cause of inflammation in inflammatory bowel disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-C (M1)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Contraception/Reproduction;Dementia;Estrogen;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Menopause;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Women's Health Research

PHR: PROJECT NARRATIVE The proposed project will comprehensively assess the contribution of early menopause (natural and surgical) to overall risk and Black-White disparities in AD/ADRD diagnoses (adjudicated-AD/ADRD) and development (cognitive decline and neuroimaging markers of AD/ADRD) by harmonizing data from 25,051 women (30% Black) in three cohorts spanning midlife to older age. This project will elucidate unique midlife targets for AD/ADRD prevention in women, explicating the importance of maintenance of reproductive organs and reproductive aging’s role in women’s, especially Black women’s, long-term health.

PI_NAMEs: REEVES, ALEXIS  (contact)

PROGRAM_OFFICER_NAME: MARTIN, DAMALI

PROJECT_TERMS: Address;adjudication;Affect;Age;Age of Onset;aged;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Award;Bilateral oophorectomy;Black Populations;Black race;black women;black/white disparity;brain volume;cardiometabolism;cardioprotection;cardiovascular health;cohort;Data;data harmonization;Data Pooling;dementia risk;Development;Diagnosis;Disparity;Disparity in diagnosis;Ensure;Epidemiologist;Episodic memory;Exposure to;Funding;Gonadal Steroid Hormones;Health;High Prevalence;Hormones;human old age (65+);Hysterectomy;Impaired cognition;Individual;Intervention;late life;Life Cycle Stages;Longitudinal cohort;magnetic resonance imaging biomarker;Maintenance;Measurement;Mediator;men;Menopause;Mentors;Methods;middle age;Modeling;modifiable risk;neurocognitive test;neuroimaging marker;neuroprotection;Operative Surgical Procedures;Patient Self-Report;Perimenopause;Physicians;Postmenopause;premature;Premature Menopause;Prevalence;Provider;Publications;racial bias;racial difference;reproductive;reproductive organ;reproductive senescence;Risk;Role;Sample Size;Selection Bias;simulation;social;Study of Women's Health Across the Nation;surgical menopause;Time;Training;verbal;White Matter Hyperintensity;White Women;Woman;Women's Health;women's prevention;Work

PROJECT_TITLE: The Role of Reproductive Aging for Racial Differences in AD/ADRD from Midlife to Older Age

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development Facilitating The Transition to Independence Study Section[AGCD-1]