NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Gene Therapy;Genetics;Human Genome;Neurosciences;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

PHR: Currently there are no proven therapies to treat recurrent GBM largely due to our inadequate molecular understanding of the disease. Glioma stem-cells (GSCs) are critical determinants of intra-tumor heterogeneity, tumor propagation, therapeutic resistance, and recurrence following treatment. It is therefore imperative that we understand the molecular mechanisms underlying GSC plasticity to design rational therapeutics aimed at stopping the conversion of non-GSCs to GSCs to limit intra-tumor heterogeneity, eliminate transitions between cellular states, and block the emergence of therapy-resistant cells.

PI_NAMEs: LOPEZ-BERTONI, HERNANDO MARTIN (contact)

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: Advanced Development;Affect;aggressive therapy;Architecture;Automobile Driving;Brain Neoplasms;Cell model;Cells;chemotherapy;Chromatin;Chromium;Data;design;Development;Dimensions;Disease;ELF3 gene;Epigenetic Process;Esters;Formulation;Gene Delivery;Generations;Genetic Transcription;Genomics;Glioblastoma;Glioma;glioma cell line;Goals;Heterogeneity;Human;improved;in vivo;innovation;Long-Term Survivors;Maintenance;Messenger RNA;microRNA delivery;MicroRNAs;Molecular;nano;nanoparticle;new therapeutic target;next generation;novel;Nucleosomes;Oncogenes;Oncogenic;Operative Surgical Procedures;Pathogenesis;Pathway interactions;Patient-Focused Outcomes;Patients;Phenotype;Polymers;Population;Positioning Attribute;pre-clinical;prevent;Progression-Free Survivals;Publishing;Radiation;Radio;rational design;Recurrence;Recurrent tumor;Resistance;Resolution;RNA;Role;self-renewal;single cell genomics;single cell sequencing;standard of care;stem cells;stem-like cell;stemness;System;targeted agent;Technology;temozolomide;Testing;TGFBR2 gene;Therapeutic;Therapeutic Intervention;therapeutic miRNA;therapeutic target;therapy resistant;tool;transcriptome;transcriptomics;Treatment Efficacy;tumor;tumor growth;tumor heterogeneity;tumorigenesis;Xenograft Model

PROJECT_TITLE: Molecular determinants of cellular heterogeneity and therapeutic resistance in GBM.

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 1 Study Section[MCT1]


ADMINISTERING_IC: DE

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Infectious Diseases;Microbiome

ORG_CITY: ANN ARBOR

ORG_COUNTRY: UNITED STATES

ORG_DEPT: DENTISTRY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE The overarching goal of this research is to determine the mechanisms by which Treponema denticola interacts with host tissue in the oral environment and contributes to the dysregulation of host tissue homeostasis pathways that leads to periodontitis. The proposed studies will directly support this goal by characterizing specific mechanisms by which T. denticola interacts with host cell proteins that control key pathways required for maintenance of tissue homeostasis. Our research team, with demonstrated experience in genetic manipulation and functional assays of T. denticola behavior, as well as in fine-scale analysis of host cell and tissues responses, is uniquely qualified to conduct these studies.

PI_NAMEs: FENNO, J CHRISTOPHER (contact);KAPILA, YVONNE L

PROGRAM_OFFICER_NAME: CHANDER, PREETHI

PROJECT_TERMS: Acylation;Affect;alveolar bone;Alveolar Bone Loss;Animal Model;anti-microbial peptide;bacteriocin;Behavior;Binding;Biochemical;Biological Assay;Biology;Calcium;Cell model;Cell Separation;Cells;Chronic;chronic infection;Complex;Cytopathology;Cytoskeleton;cytotoxic;Data;dentilisin;Disease;Disease Progression;dysbiosis;Environment;Event;experience;Extracellular Matrix;Fibronectins;Gelatinase A;Generations;Genetic;genetic analysis;genetic manipulation;Goals;Health Transition;Homeostasis;host-microbe interactions;Human;Immune response;immunoregulation;in vivo;Individual;Inflammatory;insight;Integration Host Factors;Integrins;Intercellular Junctions;interest;intermolecular interaction;Knowledge;Lesion;lipooligosaccharide;Lipoproteins;Maintenance;Matrix Metalloproteinases;Mediating;Mediator;Membrane;Membrane Proteins;Metabolic;model organism;Molecular Analysis;Molecular Biology;mouse model;Mouth Diseases;mutant;Mutation;Nisin;Oral;oral spirochetes;Order Spirochaetales;osteoblast differentiation;Parents;pathobiont;Pathway interactions;Penetration;Peptide Hydrolases;Periodontal Diseases;Periodontal Ligament;Periodontitis;Phosphorylcholine;Positioning Attribute;protein complex;protein protein interaction;Proteins;PTK2 gene;Qualifying;Recombinant Proteins;Research;response;Role;Signal Transduction;Surface;systemic inflammatory response;Testing;therapeutic target;Tissues;TLR2 gene;Tooth Socket;Tooth structure;Treponema;Treponema denticola;VDAC1 gene

PROJECT_TITLE: Treponema - Host Cell and Tissue Interactions

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Heart Disease

ORG_DEPT: PHARMACOLOGY

PHR: PROJECT NARRATIVE Cardiac hypertrophy and myocardial oxidative stress are two major drivers of heart failure progression and both processes require the activity of Rac1, a small GTPase. Rac1 is known to undergo palmitoylation, a post- translational lipid modification that influences protein activity and localization, however the ability of this modification to control Rac1 signaling in the heart remains untested. This proposal seeks to determine the role of Rac1 palmitoylation in regulating cardiac hypertrophy and oxidative stress using both in vitro and in vivo approaches, thereby testing a novel regulatory mechanism of pathologic cardiac signaling that could potentially be targeted for the treatment of heart failure.

PI_NAMEs: TEUBER, JAMES PATRICK (contact)

PROGRAM_OFFICER_NAME: CHEON, YEWON

PROJECT_TERMS: Address;Angiotensin II;Cancer Model;Cardiac;Cardiac Myocytes;Cardiomyopathies;Cardiovascular Diseases;Cause of Death;Cell membrane;Cell Size;Chronic;Complex;constitutive expression;Cysteine;Data;Dependovirus;Development;Dilated Cardiomyopathy;Disease;disease model;Drug Industry;Echocardiography;Family;Fatty Acids;Fellowship;Functional disorder;Gene Expression;Genetic;genetic approach;Golgi Apparatus;Growth;Health;Heart;Heart Diseases;Heart failure;Heart Hypertrophy;Human;Hyperactivity;Hypertension;Hypertrophy;improved;In Vitro;in vitro Model;in vivo;Inflammation;Inflammatory;Infusion procedures;interest;Knock-out;Knowledge;Lipids;Malignant Neoplasms;Measures;Mediating;Membrane;Modeling;Modification;Monomeric GTP-Binding Proteins;mortality;Multienzyme Complexes;Mus;mutant;Mutate;Mutation;Myocardial;Neonatal;Nodal;novel;novel therapeutics;Osmosis;overexpression;Oxidases;Oxidation-Reduction;Oxidative Stress;Oxidative Stress Induction;palmitoylation;Pathogenesis;Pathogenicity;Pathologic;Patients;Play;pre-clinical;Pre-Clinical Model;Process;Production;Proteins;Public Health;Pump;Rattus;Reactive Oxygen Species;Regulation;Research Personnel;response;rho;Role;Saline;Scientist;Serine;Signal Induction;Signal Transduction;Signaling Protein;skills;small molecule;spatiotemporal;stem;Stimulus;targeted treatment;Testing;Time;Training;Transgenic Mice;United States;Weight;Work;Workload

PROJECT_TITLE: Determining the role of Rac1 palmitoylation in cardiac hypertrophy and oxidative stress


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Breast Cancer;Cancer;Women's Health Research

ORG_CITY: JACKSONVILLE

ORG_NAME: MAYO CLINIC  JACKSONVILLE

ORG_STATE: FL

PHR: PROJECT NARRATIVE “Triple negative” breast cancer (TNBC) is a subtype of breast cancer that spreads aggressively and often leads to metastasis and death; it is difficult to treat because it does not respond to current molecularly-targeted drugs. TIMP2 is a natural human protein with two anticancer activities: (1) it inhibits an enzyme involved in TNBC metastasis, and (2) it binds to a cell surface receptor to inhibit TNBC growth. We propose to develop a new cancer drug, based on TIMP2, with improved capability to inhibit both metastasis and tumor growth, providing a new therapy to improve survival for patients with TNBC.

PI_NAMEs: RADISKY, EVETTE S (contact)

PROGRAM_OFFICER_NAME: COUCH, JENNIFER A

PROJECT_TERMS: Active Sites;Affinity;angiogenesis;anti-cancer;anti-cancer therapeutic;anticancer activity;Binding;breast cancer metastasis;breast cancer progression;Breast Cancer therapy;cancer therapy;candidate identification;Cell Surface Receptors;Cells;Cessation of life;Clinical;clinical development;Collection;Complex;Computer Models;Dependence;design;Development;Directed Molecular Evolution;Dose Limiting;Engineering;Enzyme Inhibition;Enzyme Precursors;Enzymes;experimental study;Extracellular Matrix;Family;Gelatinase B;Growth;Homeostasis;hormone receptor-negative;Human;human model;implantation;improved;improved outcome;in vivo;in vivo Model;Individual;Inhibition of Matrix Metalloproteinases Pathway;inhibitor;innovation;insight;Integrin alpha3beta1;Integrin Binding;Invaded;Ions;Knowledge;Libraries;Malignant Breast Neoplasm;Malignant Neoplasms;Matrix Metalloproteinase Inhibitor;Matrix Metalloproteinases;Mediating;Metalloproteases;Methodology;Molecular;molecular drug target;molecular targeted therapies;mouse model;Mus;Musculoskeletal;Mutation;N-terminal;Neoplasm Metastasis;Neutrophil Collagenase;novel;novel anticancer drug;novel strategies;novel therapeutics;patient derived xenograft model;Patients;Peptide Hydrolases;Pharmaceutical Preparations;Pre-Clinical Model;preclinical development;prevent;Protease Inhibitor;Protein Engineering;protein structure;Proteins;prototype;Publishing;receptor;Research;response biomarker;Role;screening;Site;small molecule;Specificity;Structure;Surface;targeted cancer therapy;targeted treatment;Technology;Tertiary Protein Structure;Therapeutic;therapeutic protein;therapeutic target;Tissue Engineering;Tissue Inhibitor of Metalloproteinases;Tissues;Toxic effect;Transgenic Model;Transgenic Organisms;Treatment Efficacy;triple-negative invasive breast carcinoma;Tumor Angiogenesis;tumor growth;tumor microenvironment;tumor progression;Variant;Work;X-Ray Crystallography;Yeasts;Zinc

PROJECT_TITLE: Engineering tissue inhibitor of metalloproteinases-2 (TIMP-2) for triple negative breast cancer therapy

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 2 Study Section[MCT2]


ADMINISTERING_IC: GM

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: SAN JUAN

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF PUERTO RICO MED SCIENCES

ORG_STATE: PR

PHR: The over-arching goal of the G-RISE RISE Program at the University of Puerto Rico Medical Sciences is to support educational activities that enhance the diversity of the biomedical, behavioral and clinical research workforce, through support of creative educational activities with a primary focus on: Research Experiences and Courses for Skills Development. The University of Puerto Rico Medical Sciences Campus requests support for Mentored Research Experiences and Skills Development activities for better prepare URM scientists. Innovative approaches are included, such as a course in Reproducible Quantitative Research for Biomedical Translational Scientists, fellowship proposal writing and teaching skills courses.

PI_NAMEs: BARRETO ESTRADA, JENNIFER LUZ;CADILLA, CARMEN LYDIA (contact);GONZALEZ-MENDEZ, RICARDO RAMON;MIRANDA, JORGE DAVID

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TITLE: G-RISE at the University of Puerto Rico Medical Sciences Campus

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - C[TWD-C]


NIH_SPENDING_CATS: Bioengineering;Dental, Oral, and Craniofacial Disease;Genetics;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: Project Narrative As human teeth have limited regenerative potential, tooth loss is a common and chronic condition that can deeply affect our lifestyles. The continuously growing mouse incisor offers an ideal system to study dental stem cells and a thorough understanding of the molecular process that regulates tooth stem cells is crucial to efforts to develop stem cell-based therapies for regenerating human teeth. We propose to investigate the role of tissue architecture and forces during dental epithelial renewal in mice and the proposed study will be transformative because it will for the first time reveal how these physical factors are coordinated to control gene expression in epithelial stem cells.

PI_NAMEs: HU, JIMMY KUANG-HSIEN (contact)

PROGRAM_OFFICER_NAME: VERBRIDGE, SCOTT SPENCER

PROJECT_TERMS: 3-Dimensional;Ablation;Address;Adult;adult stem cell;Affect;Alleles;Architecture;Atomic Force Microscopy;Biochemical;Biological Models;Biomechanics;Biomedical Engineering;Cell Density;Cell Differentiation process;Cell Maintenance;Cell Nucleus;Cell Physiology;Cell Shape;Cells;Chromatin;Chromatin Structure;Chronic;Clinical;cofactor;Community Medicine;Data;Dental;Devices;differential expression;Epigenetic Process;epithelial stem cell;Epithelium;Exhibits;experimental study;force sensor;Future;Gene Expression;gene repression;Genetic Transcription;Geometry;Goals;Heterochromatin;Homeobox Genes;Human;Image;In Situ;in vivo;Incisor;injury and repair;interest;Knowledge;Lamin Type A;Lasers;Life Style;loss of function;Magnetism;Maps;Measures;mechanical force;mechanical signal;Mechanics;Mediating;Medicine;Membrane Proteins;Microscopy;Microtubules;Molecular;mouse genetics;mouse model;Mus;novel;Nuclear;Nuclear Envelope;Nuclear Import;Nuclear Pore;Nuclear Protein;Oils;Organ;Pattern;Phenotype;physical property;Polycomb;Process;progenitor;protein expression;Proteins;Public Health;regeneration potential;Regenerative Medicine;regenerative therapy;Regulation;Repression;Research Personnel;response;Role;Shapes;Signal Transduction;stem cell biology;stem cell fate;stem cell function;stem cell model;stem cell niche;stem cell proliferation;stem cell therapy;stem cells;Stress;System;Testing;theories;Time;Tissues;Tooth Loss;Tooth regeneration;Tooth structure;Transcriptional Regulation;Weight-Bearing state;Work

PROJECT_TITLE: Mechanical regulation of transcription in dental epithelial stem cells through cell packing and tissue forces

STUDY_SECTION: SBDD

STUDY_SECTION_NAME: Skeletal Biology Development and Disease Study Section[SBDD]


ORG_DEPT: PHYSIOLOGY

PHR: PROJECT NARRATIVE Secondary active transporters are essential components of cellular physiology. In humans, they are implicated in numerous diseases and are considered targets of active pharmaceutical interest. We aim to structurally resolve human sugar transporters with medical relevance in type II diabetes, microbial infections, and other conditions related to sugar transport and metabolism. These structural studies will be complemented using spectroscopy, advanced X-ray scattering and Molecular Dynamics simulations in an effort to elucidate the molecular mechanisms of sugar transporter.

PI_NAMEs: ABRAMSON, JEFFREY S (contact)

PROGRAM_OFFICER_NAME: BOND, MICHELLE RUEFFER

PROJECT_TERMS: absorption;Award;Biochemical;Bioenergetics;Biomedical Research;biophysical properties;Blood Circulation;Blood Glucose;Cell Physiology;Disease;Dreams;drug development;Enterocytes;flexibility;Funding;Glucose;Glucose Transporter;Golgi Apparatus;high risk;Hormonal;Human;Infection;interest;Kidney;macromolecule;Medical;Membrane Transport Proteins;Metabolism;Methodology;microbial;Molecular;Molecular Conformation;molecular dynamics;National Institute of General Medical Sciences;Non-Insulin-Dependent Diabetes Mellitus;novel strategies;Pathway interactions;Pharmacologic Substance;Process;Production;Protein Glycosylation;Research;Research Personnel;Roentgen Rays;Role;Scheme;Science;Scientist;Small Intestines;Sodium;Source;Spectrum Analysis;Structure;Structure-Activity Relationship;sugar;sugar nucleotide;Voltage-Dependent Anion Channel

PROJECT_TITLE: Deciphering molecular details of cellular sugar transport and their roles in disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-G(55)R]


NIH_SPENDING_CATS: Bioengineering;Cancer;Clinical Research;Digestive Diseases;Orphan Drug;Pancreatic Cancer;Precision Medicine;Rare Diseases

ORG_CITY: DALLAS

ORG_DEPT: SURGERY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: Therapies that target tumor architecture (e.g., the stroma compartment) have proven efficacy in preclinical studies and have led to ongoing clinical trials. This is the proof-of-concept of the existence of tissue-specific properties that regulate tumor architecture during tumor progression and in response to chemotherapy. Our proposed study aims to identify the mechanisms that regulate tumor tissue homeostasis (i.e., multicellular dynamics) to find novel therapeutic strategies for patients with pancreatic cancer (PDAC), to define the role of tumor architecture in PDAC chemoresistance, and to discover new biomarkers to predict the response to multi- agent chemotherapy (i.e., FOLFIRINOX).

PI_NAMEs: LIGORIO, MATTEO  (contact)

PROGRAM_OFFICER_NAME: BHARTI, SANITA

PROJECT_TERMS: Adult;Aftercare;Architecture;Behavior;Biological;Biological Markers;cancer cell;Cells;Chemoresistance;chemotherapy;Clinical Trials;Color;Core Biopsy;CRISPR screen;Disease Progression;Engineering;Evolution;Extracellular Matrix;Fibronectins;genome-wide;Gland;Goals;Homeostasis;Human;human tissue;Imaging Techniques;Immunotherapy;Impairment;improved;in vivo imaging;in vivo two-photon imaging;Individual;innovation;insight;Knowledge;Malignant neoplasm of pancreas;Malignant Neoplasms;MAP Kinase Gene;Methodology;Methods;mouse model;Mus;Names;novel marker;novel therapeutic intervention;novel therapeutics;Pancreas;pancreatic cancer patients;Pancreatic Ductal Adenocarcinoma;Pathway interactions;Patients;Phenotype;preclinical study;predicting response;predictive marker;preservation;Prognosis;prognostic value;programs;Proliferating;Property;Publishing;Refractory;refractory cancer;Reporter;research study;Research Support;Resolution;response;Role;Shapes;Solid Neoplasm;STAT3 gene;Structure;subcutaneous;Survival Rate;synergism;System;targeted treatment;Testing;Time;time use;Tissues;treatment response;tumor;tumor behavior;tumor progression;Tumor Tissue;two photon microscopy;Work

PROJECT_TITLE: Targeting tumor architecture as a novel therapeutic strategy for pancreatic cancer

STUDY_SECTION: TPM

STUDY_SECTION_NAME: Tumor Progression and Metastasis Study Section[TPM]


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Brain Disorders;Cerebrovascular;Complementary and Integrative Health;Dementia;Lung;Lymphatic Research;Neurodegenerative;Neurosciences;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: NEW HAVEN

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative The glymphatic and lymphatic systems control fluid and waste disposal from the central nervous system, and are therefore pivotal for sustaining a healthy brain. However, the functional interplay between the glymphatic and lymphatic systems has been technically difficult to study. Consequently, targeting optimization of the functional cross-talk of the two systems for potential health benefits are still under-investigated. Our goal is to characterize the mechanisms regulating the glymphatic/lymphatic system coupling by introducing unique imaging, computational fluid dynamics analysis, and lymph “omics”. Successful completion of our studies will determine the physiological drivers of glymphatic/lymphatic coupling and fast-forward testing of beneficial alternative approaches based on posture and respiratory manipulations.

PI_NAMEs: BENVENISTE, HELENE D (contact);KIPNIS, JONATHAN ;PAPADEMETRIS, XENOPHON ;SANTAMBROGIO, LAURA

PROGRAM_OFFICER_NAME: BELFER, INNA

PROJECT_TERMS: Acceleration;Affect;Angiotensins;Animal Model;Apnea;ATP phosphohydrolase;Biochemical;biophysical analysis;Biophysics;Blood - brain barrier anatomy;Brain;brain control;Brain Drains;Brain Mapping;Breathing;Calcium Signaling;Cannulations;carbonate dehydratase;Cardiopulmonary;Cardiovascular system;Central Nervous System;Central venous pressure;Cerebrospinal Fluid;Cervical;Cervical lymph node group;clinically relevant;common treatment;Computer Analysis;Continuous Positive Airway Pressure;Coupled;Coupling;Data;Device Designs;Diffusion;Drainage procedure;Excision;experimental study;Extracellular Protein;Feedback;Fluid Balance;Functional disorder;glymphatic function;glymphatic system;Goals;Health Benefit;hemodynamics;Homeostasis;Image;Impaired cognition;in vivo imaging;Inflammation;innovation;Intercellular Fluid;Intracranial Pressure;Investigation;Ion Transport;Knowledge;Laboratories;life span;Ligature;Liquid substance;Lymph;lymph flow;Lymph Node Mapping;Lymphatic;lymphatic drainage;Lymphatic function;Lymphatic System;lymphatic vessel;Magnetic Resonance Imaging;Maps;Measurement;Mechanics;Meningeal lymphatic system;Modality;Molecular;Monitor;Morphology;nCPAP Ventilation;novel;Pathway interactions;Peptides;Physiologic Monitoring;Physiological;Posture;prevent;Production;protein function;Proteins;proteomic signature;Proteomics;Protons;Refuse Disposal;Relaxation;Renin;Renin-Angiotensin System;respiratory;response;Rodent;Role;Series;Signal Transduction;Sinus;solute;Spinal Cord;Stress;stressor;System;systemic intervention;Techniques;Testing;theories;Therapeutic;Tidal Volume;Visualization;voltage;wasting

PROJECT_TITLE: Lymphatics-Glymphatics in CNS Fluid Homeostasis


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Biotechnology;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: RENSSELAER

ORG_NAME: STEMCULTURES, LLC

ORG_STATE: NY

PHR: Narrative: The use of fetal bovine serum (FBS) to support cell growth is challenged by variability, limited supply, viral contaminants, and ethical questions. We propose to reduce FBS use by identifying the growth factors (GFs) that stimulate retinal pigment epithelium (RPE) cell growth. These GFs will be encapsulated in a controlled-release GF microbead product for serum-free RPE cell research and manufacture.

PI_NAMEs: ROBERTS, KRISTINA ;STERN, JEFFREY H (contact)

PROGRAM_OFFICER_NAME: BILLINGSLEA, EDDIE

PROJECT_TERMS: Animals;Asia;Biomedical Engineering;Cardiac Myocytes;Catalogs;Cattle;Cell Culture Techniques;Cell Cycle;cell growth;cell replacement therapy;cell type;Cells;Cellular Structures;clinical lot;Collaborations;Collection;commercial launch;commercialization;Complex;controlled release;Culture Media;Cultured Cells;Cyclic GMP;Data;Dependence;Development;Devices;Encapsulated;Endotoxins;Enzyme-Linked Immunosorbent Assay;Epithelial Cell Proliferation;Epithelial Receptor Cell;Ethics;Europe;Experimental Designs;Feedback;fetal bovine serum;Fetal Reduction;Future;Goals;Growth;Growth Factor;Human;human stem cell-derived;Hydrogels;improved;Knowledge;Life;manufacture;Manufacturer;Marketing;Measures;Mesenchymal Stem Cells;Methods;Microspheres;Modernization;nerve stem cell;pathogen;Pathway interactions;Phase;pigment epithelium-derived factor;Predictive Factor;Preparation;Production;Proliferating;Proteomics;Recombinant Growth Factor;Recombinants;Reproducibility;Research;research and development;retinal stimulation;Risk;Sampling;Serum;Serum-Free Culture Media;Signal Transduction;Small Business Technology Transfer Research;Source;Standardization;stem cell replacement;Sterility;Stimulus;Structure of retinal pigment epithelium;Supporting Cell;T-Lymphocyte;Testing;therapy development;Time;transcriptomics;Viral;Work;Writing

PROJECT_TITLE: Controlled-release Microbeads to Replace Growth Factors in Fetal Bovine Serum

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-F(10)B]


ADMINISTERING_IC: MH

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Data Science;Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: SEATTLE

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Summer Institute in Neuroimaging and Data Science: Project Narrative The Summer Institute in Neuroimaging and Data Science (“NeuroHackademy”) provides training in state-of-the- art data science methods and resources, such as programming, data stewardship, and machine learning, that are underrepresented in traditional neuroscience curricula. Through lectures, hands-on training sessions, and team projects, the skills taught by the SINDS will empower scientists from diverse backgrounds to use these tools in research on the human brain and on neurological and psychiatric brain disorders.

PI_NAMEs: ROKEM, ARIEL SHALOM (contact)

PROGRAM_OFFICER_NAME: VAN'T VEER, ASHLEE VICTORIA

PROJECT_TERMS: Address;Adolescent;Adopted;Big Data;Brain;Brain Diseases;career;classification algorithm;cognitive development;Collection;Communities;Community of Practice;Competence;computer science;Computer software;connectome;Data;Data Analyses;Data Collection;data ecosystem;Data Science;Data Science Core;Data Set;data visualization;Database Management Systems;Databases;Dedications;design;Discipline;e-science;Educational Curriculum;Educational process of instructing;empowerment;experimental study;Face;Faculty;Familiarity;follow-up;Fostering;Funding;Habits;hackathon;Home;Human;Influentials;insight;Institution;Instruction;instructor;Knowledge;knowledgebase;large datasets;Learning;lectures;Machine Learning;Magnetic Resonance Imaging;Methodology;Methods;multi-scale imaging data;neuroimaging;Neurologic;Neurosciences;novel;open source;parallelization;Participant;Positioning Attribute;prediction algorithm;Problem Solving;programs;Reproducibility;Research;Research Personnel;Resources;Science;Scientist;Site;skills;Software Engineering;Software Tools;statistics;Structure;Students;success;summer institute;Technical Expertise;Technology;Testing;theories;tool;Training;Training Programs;United States National Institutes of Health;Universities;Visualization;Washington;webinar


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Orphan Drug;Ovarian Cancer;Rare Diseases;Women's Health Research

ORG_CITY: PHILADELPHIA

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Narrative: Poly polymerase inhibitor drugs (PARPi's) have emerged as important new therapeutic agents targeting a broadening class of gene mutations present in breast, ovarian, prostate and a host of other cancers. To further the development, clinical translation, and commercialization of [18F]Fluorthanatrace ([18F]FTT), a PET tracer of PARP1 expression and drug binding, we propose an Academic Industrial Partnership (AIP) comprised of The University of Pennsylvania (lead academic partner), MD Anderson Cancer Center, and Washington University with Trevarx Biomedical, Inc. The proposed effort by the AIP will generate elements to design and implement a pivotal Phase 3 trial for [18F]FTT FDA approval, as well as support [18F]FTT commercial supply and ongoing/future research evaluating the value of [18F]FTT PET/CT for guiding PARP inhibitor treatment to the benefit of many cancer patients.

PI_NAMEs: LIN, LILIE LEMING;MANKOFF, DAVID A. (contact);MCDONALD, ELIZABETH

PROGRAM_OFFICER_NAME: BEIER, HOPE THOMAS

PROJECT_TERMS: analog;Autoradiography;Binding;Biological Assay;Biological Markers;BRCA mutations;Breast;Cancer Center;Cancer Patient;Chemistry;Clinical;Clinical Data;clinical translation;Clinical Trials;commercialization;Data;Defect;design;Development;Diagnosis;Diagnostic;diagnostic accuracy;Elements;Formalin;Freezing;Future;Gene Mutation;Good Manufacturing Process;homologous recombination;Image;imaging biomarker;Immunofluorescence Immunologic;Immunohistochemistry;improved;In Vitro;in vivo;industry partner;inhibitor therapy;Label;Lead;Licensing;Malignant Breast Neoplasm;Malignant neoplasm of ovary;Malignant Neoplasms;manufacture;Measures;Methodology;Methods;Multicenter Trials;neoplastic cell;novel therapeutics;Ovarian;Paraffin Embedding;Patients;Pennsylvania;PET/CT scan;Pharmaceutical Preparations;Phase;phase 3 study;phase II trial;phase III trial;Poly(ADP-ribose) Polymerase Inhibitor;Poly(ADP-ribose) Polymerases;Polymerase;Positron-Emission Tomography;predicting response;Principal Investigator;Production;programs;prospective;Prostate;Protocols documentation;Radiopharmaceuticals;Reference Standards;Research;Site;Specific qualifier value;Standardization;targeted treatment;Testing;Time;Tissue Embedding;Tissues;Toxic effect;Tracer;trial comparing;trial design;tumor;Universities;uptake;Validation;Washington;wasting

PROJECT_TITLE: Breast Cancer PARP PET Imaging AIP to Support FDA Approval & Commercialization


ORG_CITY: MILWAUKEE

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: Atherosclerosis is initiated and promoted by the arterial accumulation of apolipoprotein B (apoB)-containing lipoproteins which activate a chronic inflammatory response. Our group recently made the novel discovery that a key blood clot lysis protein, tissue-type plasminogen activator (tPA), in hepatocytes limits the production of apoB-lipoproteins in mice and cultured human primary hepatocytes. The overarching objective of this proposal is to explore the underlying mechanisms by which hepatocyte tPA lowers plasma apoB-containing lipoprotein- cholesterol levels, and thereby alleviates atherosclerosis.

PI_NAMEs: ZHENG, ZE  (contact)

PROGRAM_OFFICER_NAME: LIU, LIJUAN

PROJECT_TERMS: Alteplase;Apolipoproteins B;Atherosclerosis;atherosclerosis risk;Binding;Blood;Blood coagulation;cardiovascular disorder risk;Cells;Cholesterol;Chronic;comparison control;Cytolysis;Data;Diameter;Diet;Dyslipidemias;Fatty acid glycerol esters;fatty liver disease;Hepatic;Hepatocyte;Homeostasis;Human;Hypertriglyceridemia;IDL lipoproteins;Inflammatory Response;inhibitor;insight;intrahepatic;LDL Cholesterol Lipoproteins;Lipids;lipoprotein cholesterol;Lipoproteins;Liver;Low Density Lipoprotein Receptor;Low-Density Lipoproteins;Mediating;Molecular;Mus;new therapeutic target;novel;particle;Plasma;Plasminogen;Plasminogen Activator;Population;Production;Proteins;Residual state;Risk;Role;Serum;Source;Testing;Therapeutic;therapeutic target;Triglycerides;Very low density lipoprotein;Very low density lipoprotein cholesterol;Wild Type Mouse

PROJECT_TITLE: The role of hepatocyte tPA in hepatic VLDL production.

STUDY_SECTION: AVI

STUDY_SECTION_NAME: Atherosclerosis and Vascular Inflammation Study Section[AVI]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Digestive Diseases;Genetics;Inflammatory Bowel Disease

ORG_CITY: CLEVELAND

ORG_DEPT: PATHOLOGY

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative Ulcerative colitis (UC) is an inflammatory bowel disease (IBD) affecting over 1 million people in the United States and its incidence is increasing. Our study addresses the challenge of identifying preclinical human IBD mechanisms and focuses on the role of the protein Sam68 as a critical mediator of tumor necrosis factor (TNF) and toll like receptor (TLR) induced inflammation in UC. Successful completion of this study will reveal Sam68 as a key player in UC pathogenesis and lead to the design of novel therapeutics targeting Sam68 for chronic inflammatory conditions.

PI_NAMEs: RAMAKRISHNAN, PARAMESWARAN  (contact)

PROGRAM_OFFICER_NAME: PERRIN, PETER J

PROJECT_TERMS: 3-Dimensional;Acute;Address;Adverse event;Affect;Apoptosis;Binding;Biochemical;Biological Assay;Biological Response Modifier Therapy;Bone Marrow Transplantation;Caspase;Cell Line;Cells;chemically induced colitis;chromatin immunoprecipitation;Chronic;chronic inflammatory disease;Coculture Techniques;cohort;Colitis;Colon;Colonic inflammation;Complex;conditional knockout;CRISPR/Cas technology;cytokine;Cytoplasm;Deletion Mutation;design;Development;Digestive System Disorders;Disease remission;DNA-Protein Interaction;Environmental Risk Factor;Epithelial Cell Proliferation;Epithelial Cells;experimental study;Future;Gel;Gene Expression;Genes;Genetic;Genetic Transcription;Growth;gut inflammation;Hematopoietic;Human;Immune;improved;in vivo;Incidence;Infection;Inflammation;Inflammation Mediators;Inflammatory;Inflammatory Bowel Diseases;intestinal epithelium;intestinal homeostasis;Intestinal permeability;Intestines;Knock-out;Knockout Mice;Knowledge;Malignant Neoplasms;Mediating;Mediator;Membrane;Modeling;Molecular;Mucositis;Mucous Membrane;murine colitis;Mus;new therapeutic target;novel;novel therapeutic intervention;Organoids;Oxazolone;Partial Remission;Pathogenesis;Pathogenicity;Pathologic;Pathway interactions;Patients;Permeability;Persons;Play;Point Mutation;Post-Translational Protein Processing;pre-clinical;Proctitis;Proliferating;protein protein interaction;Proteins;Receptor Signaling;Refractory;Relapse;Research;Risk;RNA Binding;RNA-Binding Proteins;Role;Signal Pathway;Signal Transduction;Signaling Protein;Sodium Dextran Sulfate;Spontaneous colitis;SRC-associated p68 protein;Structure-Activity Relationship;System;targeted treatment;Testing;Therapeutic;Tissues;TLR2 gene;TNF gene;Toll-Like Receptor Pathway;Toll-like receptors;tool;transcription factor;Transcriptional Activation;transcriptome sequencing;treatment strategy;Tumor Necrosis Factor Receptor;tumor necrosis factor receptor binding;Ulcerative Colitis;United States;vector;Wiskott-Aldrich Syndrome;Work

PROJECT_TITLE: Role of Sam68 in Proinflammatory Signaling

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-H(04)]


NIH_SPENDING_CATS: Neurosciences;Nutrition;Obesity

ORG_CITY: BOSTON

ORG_NAME: HARVARD MEDICAL SCHOOL

ORG_STATE: MA

PHR: Project Narrative Leptin resistance is thought to be a major contributor to obesity, but its mechanisms are poorly understood. Deletion of LRP1, an endocytic receptor and putative effector of leptin transcytosis, in the choroid plexus epithelium replicates aspects of leptin resistance, suggesting leptin transcytosis through the choroid plexus as a potential bottleneck in leptin-mediated suppression of feeding. The focus of this proposal is to quantitatively dissect the role of choroid plexus transcytosis in mediating the CNS effects of leptin and to consider leptin transcytosis as a novel target for treatments of obesity and other metabolic disorders.

PI_NAMEs: KALUGIN, PETER NIKOLAEVICH (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Acute;Adipocytes;Adipose tissue;Adult;Animals;Apical;Area;awake;Binge Eating;Blood;Blood - brain barrier anatomy;Blood capillaries;blood cerebrospinal fluid barrier;Body Weight;Brain;Calcium;calcium indicator;Central Nervous System;Cerebrospinal Fluid;Choroid Plexus Epithelium;Critical Pathways;Cues;Data;design;Disease;Dopamine;dopaminergic neuron;Eating;Endocrine;Endothelium;Energy Metabolism;Epithelial Cells;Epithelium;Exhibits;experimental study;Fasting;Fatty acid glycerol esters;feeding;Feeding behaviors;Food;food consumption;Food Intake Regulation;gene therapy;Genetic Polymorphism;glucose tolerance;Goals;High Fat Diet;Homeostasis;Hormones;Human;Image;Imaging Techniques;Impairment;in vivo;in vivo imaging;Individual;Infusion procedures;insight;Insulin Resistance;Knock-out;Label;LDL-Receptor Related Protein 1;Leptin;Leptin resistance;Lipoprotein Receptor;Liquid substance;Low Density Lipoprotein Receptor;Measures;median eminence;Mediating;Metabolic;Metabolic Diseases;Methods;Molecular;monolayer;Motivation;Mus;neural;neural circuit;Neurons;Neurosecretory Systems;novel;novel therapeutic intervention;Obese Mice;Obesity;obesity development;obesity treatment;overexpression;Pathway interactions;Peripheral;Phenotype;Plasma;Prediabetes syndrome;Process;Proteins;receptor;Regulation;response;Rewards;Role;Satiation;Serum;Signal Transduction;Structure of choroid plexus;Surface;Testing;Thinness;Time;tool;transcytosis;Tropism;two-photon;Ventral Tegmental Area;Viral Vector;Visualization;Wild Type Mouse;Work

PROJECT_TITLE: Gating of Leptin Transport into the Cerebrospinal Fluid at the Choroid Plexus


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Chronic Pain;Clinical Research;Comparative Effectiveness Research;Complementary and Integrative Health;Health Services;Pain Research;Palliative Care;Prevention

ORG_CITY: NEW YORK

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: In 2019, over 1.7 million Americans will be diagnosed with cancer, and among the innumerable rigors associated with the diagnosis and its treatment, perhaps the greatest source of suffering is pain. Hypnosis has been shown to be a clinically efficacious and cost-effective nonpharmacologic intervention for pain, but few cancer care providers are trained in its use. The goal of the proposed R25E is to train cancer care providers in hypnosis to manage pain across the cancer continuum, so that providers may skillfully and competently deliver hypnosis to reduce the pain burden of their patients.

PI_NAMEs: MONTGOMERY, GUY H (contact)

PROGRAM_OFFICER_NAME: ELJANNE, MARIAM

PROJECT_TERMS: Activities of Daily Living;Acute;Acute pain management;Adoption;Adult;Ally;American;American Society of Clinical Oncology;anti-cancer treatment;Attitude;Behavior;Biological;Bone Pain;cancer care;cancer pain;Cancer Pain Management;Cancer Patient;Cancer Survivor;cancer therapy;care providers;chemotherapy;Chronic;Chronic Cancer Pain;chronic pain;chronic pain management;Clinical;Clinical Competence;clinical efficacy;clinical practice;clinical training;Cognitive;cohort;coping;cost effective;Country;Cultural Sensitivity;curative treatments;Degree program;Diagnosis;E-learning;Education;Educational workshop;Effectiveness;effectiveness evaluation;efficacious intervention;Eligibility Determination;Empathy;Enrollment;Ensure;Evaluation;evidence base;Exercise;experience;Feedback;Film;Future;Goals;Guidelines;health care quality;Healthcare promotion;Healthy People 2020;Hormonal;Hospitalization;Hypnosis;hypnotic;improved;Intervention;Knowledge;Learning;lectures;Licensing;Link;Malignant Neoplasms;Medical;Meta-Analysis;Methods;Mind-Body Intervention;mind/body;Minority;Mission;Modality;Multimedia;Musculoskeletal Pain;National Comprehensive Cancer Network;Neuropathy;Nonpharmacologic Therapy;online resource;Operative Surgical Procedures;Pain;Pain management;pain reduction;Participant;Patient Self-Report;Patients;pharmacologic;Phase;Play;Postoperative Pain;Preparation;Professional Organizations;Program Evaluation;programs;Provider;psychologic;psychosocial;Publishing;Quality of Care;Quality of life;Questionnaires;Radiation therapy;Radiodermatitis;Recommendation;Recording of previous events;recruit;Reporting;Research;research clinical testing;response;Role;satisfaction;Self Efficacy;Site;skills;Source;Standardization;Surveys;Survivors;survivorship;symposium;symptom management;Techniques;Terminal Disease;theories;Therapeutic;Thinking;Time;Training;Training Programs;transfer learning

PROJECT_TITLE: Training clinical providers in evidence-based hypnosis for cancer pain management

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Pediatric Cancer;Physical Activity;Prevention;Rare Diseases;Rehabilitation;Social Determinants of Health

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Narrative Social challenges are a major issue for young adult cancer patients (18-39 years old). Impairments in social relationships, referred to as social health, may decrease physical activity after a cancer diagnosis, leading to poorer quality of life after treatment and recovery. This study will investigate the relationships between social health, physical activity, and quality of life to expand our understanding of their interrelations to inform intervention strategies to foster healthy survivorship for young adult cancer patients.

PI_NAMEs: MILLER, KIMBERLY ANN (contact)

PROGRAM_OFFICER_NAME: FERRER, REBECCA

PROJECT_TERMS: Accelerometer;actigraphy;Adolescent and Young Adult;Aftercare;Age;Behavior;Breast;cancer diagnosis;Cancer Patient;Cancer Survivor;cancer therapy;Characteristics;Childhood;Chronic;Clinical;cohort;Complex;Comprehensive Cancer Center;Cross-Sectional Studies;Development;Diagnosis;Disease;Disease-Free Survival;effective intervention;Emotional;Employment;ethnic diversity;Ethnic Origin;experience;follow-up;Fostering;Gender;General Population;Health;Health Promotion;Health Status;high risk;Hospitals;Impairment;improved;Intervention;Latino;Life;Life Experience;Link;longitudinal design;Longitudinal Studies;Los Angeles;Malignant Neoplasms;Measures;Medical;Melanoma;mortality;Outcome;patient oriented;Patients;peer;Physical activity;Physical Function;Physically Challenged;Population;Process;prospective;Prospective Studies;Quality of life;Questionnaires;Race;Recovery;recruit;Reporting;Research;Risk;Risk Behaviors;Risk Factors;safety net;sedentary;sex;social;social contact;Social Functioning;Social Network;social relationships;Social support;sociodemographics;Socioeconomic Status;Structure;survivorship;Symptom Burden;Testing;Testis;Thyroid Gland;Time;Treatment-related toxicity;Vulnerable Populations;Well in self;Wrist;young adult;young cancer survivor

PROJECT_TITLE: Social Health, Activity Behaviors, and Quality of Life among Young Adult Cancer Survivors: A Longitudinal Study


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Nutrition;Prevention

ORG_DEPT: NEUROLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Relevance Mediterranean-type diet has been increasingly identified as playing an important role in preventing Alzheimer’s disease and cognitive decline in the elderly, but the mechanisms remain unclear. Several reserve concepts, including brain reserve, brain maintenance, and cognitive reserve, collectively explain individual differences in cognition, function or clinical status relative to aging and brain disease. In this proposal, using data from two well-established imaging cohorts we will examine the respect roles of brain reserve, brain maintenance, and cognitive reserve in cognitive benefits of Mediterranean-type diet.

PI_NAMEs: GU, YIAN  (contact)

PROGRAM_OFFICER_NAME: WAGSTER, MOLLY V

PROJECT_TERMS: Adherence;Adult;Age;age group;age related changes;age related decline;aged;Aging;aging brain;aging related;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease risk;Brain;Brain Diseases;Brain imaging;brain morphology;brain volume;Capital;Chronology;Clinical;Cognition;Cognitive;cognitive ability;cognitive benefits;cognitive change;cognitive function;cognitive neuroscience;cognitive reserve;cohort;Data;Deceleration;Dementia;Demographic Factors;design;Development;Diet;dietary;dietary adherence;Dietary Factors;Dietary Practices;Educational Activities;Elderly;experience;follow-up;Foundations;good diet;Health;Image;Impaired cognition;improved;Individual;Individual Differences;insight;interest;Leisure Activities;Life Experience;life span;lifestyle factors;Literature;Maintenance;Measures;Methods;middle age;modifiable lifestyle factors;multimodality;Neurobiology;neuropathology;Neuropsychology;non-demented;nutrition;older adult;Participant;Pathologic;Pathology;Play;Population;Positioning Attribute;Predisposition;prevent;Preventive measure;Process;protective factors;Proxy;public health priorities;Questionnaires;Recommendation;Research;Residual state;resilience;Role;Structure;Thick;Time;Variant;white matter;Work;young adult

PROJECT_TITLE: Diet and Cognition within a Reserve framework

STUDY_SECTION: NAME

STUDY_SECTION_NAME: Neurological, Aging and Musculoskeletal Epidemiology Study Section[NAME]


NIH_SPENDING_CATS: Brain Disorders;Down Syndrome;Intellectual and Developmental Disabilities (IDD)

ORG_CITY: Aurora

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Centrioles and centrosomes are ubiquitous and ancient macromolecular structures that are altered both in cancer cells and Trisomy 21 cells from individuals with Down syndrome. Our current research aims to understand the control mechanisms that centrioles and centrosomes exert on primary and motile cilia. We will illuminate fundamental events that contribute to cancer and Down syndrome and future studies will test whether these events are promising targets for therapeutics.

PI_NAMEs: PEARSON, CHAD G (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TERMS: Affect;Back;Biology;cancer cell;Cardiac;cell cortex;Cell Cycle;Cell Mobility;cell type;Cells;Cellular Morphology;Centrioles;Centrosome;Cilia;cilium motility;Cytoplasm;Development;Disease;dosage;Down's Syndrome;Event;extracellular;fluid flow;Foundations;Future;Genes;Genome;Goals;Homeostasis;hydrodynamic flow;Immune;Individual;Malignant Neoplasms;mechanical force;Mechanics;Messenger RNA;Metabolism;Microtubules;Mitosis;Mitotic spindle;Molecular Structure;Normal Cell;novel;Process;programs;Proteins;Reproduction;Research;Resistance;respiratory;RNA metabolism;Role;S phase;scaffold;Secretory Cell;segregation;Sensory;Signal Transduction;Spatial Distribution;System;targeted treatment;Testing;Tissues;trafficking;transmission process;Vision

PROJECT_TITLE: Centriole assembly and function for centrosome and cilia biology

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


NIH_SPENDING_CATS: Genetics;Mental Health;Neurosciences;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: DURHAM

ORG_DEPT: GENETICS

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE This project will advance our understanding of how gene regulatory elements control development of the cerebral cortex, a brain structure which underlies human cognitive capacities. It will further an understanding of the developmental brain mechanisms underlying neural cell communication and complex behavior. This study will give broad insights into the basis for neuropsychiatric disorders such as intellectual disability, autism and schizophrenia.

PI_NAMEs: SILVER, DEBRA  (contact)

PROGRAM_OFFICER_NAME: KISHORE, SANDEEP

PROJECT_TERMS: Acceleration;Address;Agonist;Apical;autism spectrum disorder;Behavior;Biological Assay;Biological Process;Brain;brain size;Cell Communication;cell cortex;Cell Cycle;cell immortalization;Cells;Cerebral cortex;Code;Cognition;cognitive capacity;Complex;Data Set;Development;Embryo;Enhancers;epigenome editing;Evolution;Exhibits;experimental study;fascinate;Gene Expression;Generations;Genes;Genetic;Genome;Genomic approach;Genomics;Goals;Human;human induced pluripotent stem cells;Image;imaging approach;Immunofluorescence Immunologic;In Vitro;Individual;induced pluripotent stem cell;innovation;insight;Intellectual functioning disability;Luciferases;Macaca;Modeling;Modification;Molecular;mouse model;Mus;Mutation;neocortical;nerve stem cell;Nervous System Disorder;Neuroanatomy;neurogenesis;Neuroglia;Neurons;neuropsychiatric disorder;neuroregulation;nonhuman primate;Nucleotides;Organoids;Pan Genus;Phenotype;Positioning Attribute;Primates;progenitor;receptor;Regulation;Regulatory Element;Reporter;Research;Role;Schizophrenia;self-renewal;Signaling Molecule;single-cell RNA sequencing;stem cell expansion;stem cell fate;stem cell function;stem cell proliferation;Structure;Testing;tool;Untranslated RNA;Variant;WNT Signaling Pathway

PROJECT_TITLE: Roles for uniquely human enhancers in brain development and WNT signaling

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


NIH_SPENDING_CATS: Cancer;Clinical Research;Contraception/Reproduction;Ovarian Cancer;Prevention;Rare Diseases;Women's Health Research

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: NARRATIVE Changing contraceptive patterns, specifically the decline of oral contraceptives and rise intrauterine devices, could have important implications for future ovarian cancer risk. Leveraging data from 24 population-based studies including more than 700,000 women (>20,000 cases) as well as ovarian cancer tissue (>3,000) to examine local immune mechanisms with cutting-edge multiplex immunofluorescence technology, we will evaluate how this highly prevalent and modifiable risk factor may impact the population burden of this extremely fatal disease.

PI_NAMEs: TERRY, KATHRYN L. (contact)

PROGRAM_OFFICER_NAME: SAMIMI, GOLI

PROJECT_TERMS: Address;African American;African American Women;Age;aged;Attenuated;Biological;Birth;cancer epidemiology;cancer risk;cancer subtypes;carcinogenesis;case control;Case/Control Studies;CD3 Antigens;CD8B1 gene;cell type;Cells;Clear Cell;cohort;Cohort Studies;Contraceptive Agents;Contraceptive methods;Contraceptive Usage;Cytotoxic T-Lymphocytes;Data;Disease;Endometrial Carcinoma;Enrollment;epidemiology study;First Births;Focal Infection;FOXP3 gene;Future;Heme;High Prevalence;Histologic;Hormonal;Immune;Immune response;Immunofluorescence Immunologic;Immunologic Markers;Incidence;Infiltration;Inflammation;innovation;Intrauterine Devices;Link;Macrophage;Malignant neoplasm of ovary;Measures;Meta-Analysis;modifiable risk;Molecular;Nature;neoplastic cell;New England;Nulliparity;Oral Contraceptives;Ovarian;ovarian neoplasm;Participant;Pathogenesis;Pathway interactions;Pattern;Physiological;Population;Population Study;Premalignant Cell;Progesterone;prospective;Prospective cohort;protective effect;protective factors;Public Health;Race;receptor expression;Regulatory T-Lymphocyte;Reporting;reproductive;Research;Resources;Risk;Risk Estimate;Risk Factors;Sample Size;scavenger receptor;Serous;Steroid Receptors;Stromal Neoplasm;Subgroup;Technology;Time;time use;Tissue Microarray;Tissues;trend;tumor;tumor microenvironment;Tumor Subtype;tumor-immune system interactions;Update;Woman;Women's Health

PROJECT_TITLE: Changing Contraceptive Patterns and Ovarian Cancer Risk

STUDY_SECTION: CHSB

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology B Study Section[CHSB]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Eye Disease and Disorders of Vision;Mental Health;Mental Illness;Neurosciences;Psychosis;Schizophrenia;Serious Mental Illness

ORG_CITY: PITTSBURGH

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative Disturbances in visual perception are highly prevalent in psychotic disorders and deficits in the processing of stimulus contrast have been linked to cognitive deficits and functional decline in chronic schizophrenia. The integrity of this mechanism, however, remains understudied at disease onset and our understanding of its modulation by coordinated yet broadly distributed cognitive systems in psychosis is lacking, limiting our attempts to target primary sources of disease morbidity. This project will examine the neural basis of visual perceptual modulation and its association with clinical impairment at first-episode psychosis to inform targeted treatment approaches.

PI_NAMEs: SKLAR, ALFREDO LUIS (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: Activities of Daily Living;Address;Adult;Age;Attention;attentional modulation;Biological Models;Brain;Chronic;Chronic Disease;Chronic Schizophrenia;Clinical;Clinical assessments;Cognitive;Cognitive deficits;cognitive system;Communication;Communities;Conflict (Psychology);critical period;Cues;Data;Detection;Development;Disease;Dorsal;early psychosis;Economic Burden;effective intervention;Electroencephalography;Evoked Potentials;Exhibits;experience;first episode psychosis;first episode schizophrenia;Frequencies;functional decline;Functional disorder;Functional impairment;Future;Goals;Human;Impaired cognition;Impairment;improved;Individual;information processing;instrument;Intervention;Left;Link;Literature;Magnetoencephalography;Mediating;Morbidity - disease rate;neural;neural correlate;Neurobehavioral Manifestations;noninvasive brain stimulation;Occupational;Onset of illness;Outcome;Patients;Perception;Performance;Pharmaceutical Preparations;Phase;Population;Prevalence;Primates;Process;Psychoses;psychotic;Psychotic Disorders;Research;response;Scalp structure;Schizophrenia;selective attention;Sensory;social;Societies;Source;Stimulus;stimulus processing;Symptom Burden;Symptoms;System;targeted treatment;Therapeutic Intervention;therapy development;Variant;Vision;Visual;Visual attention;Visual Cortex;Visual impairment;Visual Perception;visual processing;Visual System;Work

PROJECT_TITLE: Visual Network Connectivity and Perceptual Modulation in Early Psychosis

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Dissemination and Implementation Research;Social Determinants of Health

ORG_CITY: PROVIDENCE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: PROJECT NARRATIVE At this time, policy makers and health insurers are actively exploring covering Mindfulness-Based Stress Reduction, but are not equipped with recent evidence syntheses to aid those decisions. These systematic reviews and meta-analyses, done in partnership with knowledge users, will provide the needed evidence for sound decisions and demonstrate knowledge gaps for researchers to fill. Overall, this project will provide evidence syntheses that could transform Mindfulness-Based Stress Reduction health insurance coverage and access for millions of people.

PI_NAMEs: JOHNSON, BLAIR T;LOUCKS, ERIC  (contact)

PROGRAM_OFFICER_NAME: GINEXI, ELIZABETH M

PROJECT_TERMS: active control;Address;Adherence;Anxiety;Automobile Driving;behavior change;burden of illness;Certification;Chronic;chronic pain;Clinical;Clinical Trials;Code;cost effectiveness;Databases;Decision Making;Development;Diagnostic;Dose;Educational Status;Effectiveness;Elements;empowerment;Ensure;Ethnic Population;Evaluation;evidence base;formative assessment;future implementation;Gender;Health;Health Insurance;Home;implementation science;Insurance;Insurance Carriers;Insurance Coverage;Intervention Trial;Interview;Investigation;Knowledge;knowledge integration;knowledge translation;Length;Level of Evidence;Literature;Longterm Follow-up;meetings;Mental Depression;Meta-Analysis;Methodology;Methods;mindfulness;mindfulness-based stress reduction;Modality;opioid use;Outcome;Pain;Participant;Patients;people of color;Persons;Physical Function;Policies;Policy Maker;Population;Process;programs;Quality of life;racial population;Randomized, Controlled Trials;Recommendation;Research;Research Personnel;Science;Scientist;social capital;sound;Stress;System;systematic review;Taxonomy;teacher;Teacher Professional Development;Techniques;Time;translational approach;United States

PROJECT_TITLE: Mindfulness-Based Stress Reduction: An Implementation Science-Informed Systematic Review and Meta-Analysis

STUDY_SECTION: SIHH

STUDY_SECTION_NAME: Science of Implementation in Health and Healthcare Study Section[SIHH]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Facioscapulohumeral Muscular Dystrophy;Genetics;Human Genome;Muscular Dystrophy;Rare Diseases;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: GRAND RAPIDS

ORG_NAME: VAN ANDEL RESEARCH INSTITUTE

PHR: PROJECT NARRATIVE The 5-methylcytosine oxidase activity of TET proteins is critical for controlling DNA methylation patterns and gene expression, yet the mechanisms by which TET activity itself is regulated are completely unknown. We recently discovered that the protein SMCHD1 is a negative regulator of TET activity, and that SMCHD1 depletion activates gene networks that have been linked to an incurable form of muscular dystrophy. The objective of this project is to understand how SMCHD1 interacts with and controls TET-mediated epigenetic function in normal embryonic development and disease.

PI_NAMEs: PFEIFER, GERD P (contact)

PROGRAM_OFFICER_NAME: CARIFI, EMILY FORAN

PROJECT_TERMS: Address;Affect;ATP phosphohydrolase;base;Behavior;Binding;Binding Sites;Biochemical;Cell Differentiation process;Cell Line;Cells;Chromatin Structure;Chromosomes;CpG Islands;Data;defined contribution;demethylation;Development;Disease;DNA;DNA Methylation;DNA Methylation Regulation;DNA Sequence;Elements;Embryo;embryo cell;Embryonic Development;embryonic stem cell;Enhancers;Epigenetic Process;Event;experimental study;Facioscapulohumeral;Facioscapulohumeral Muscular Dystrophy;Family;flexibility;Gene Activation;Gene Expression;Gene Expression Profile;Gene Expression Regulation;gene network;Gene Silencing;Genes;Genetic Transcription;Genome;genome-wide;Genomic Segment;Homeobox;Homologous Gene;Human;human disease;human induced pluripotent stem cells;In Vitro;induced pluripotent stem cell;inhibitor;Knock-out;Laboratories;Link;loss of function;loss of function mutation;Maintenance;man;Maps;Mediating;Methylation;methylation pattern;Modeling;Molecular;Mouse Embryonic Stem Cells;Mus;Muscle;Muscle Cells;muscle degeneration;Muscular Dystrophies;mutant;Mutate;Myoblasts;novel;novel therapeutic intervention;Oxidases;oxidation;Pathway interactions;Patients;Pattern;Phenotype;promoter;protein distribution;protein protein interaction;Protein translocation;Proteins;Reaction;Regulation;Regulatory Pathway;Role;Site;Testing;Therapeutic;Toxic effect;transcription factor;transcriptome;Up-Regulation;Work

PROJECT_TITLE: 5-methylcytosine oxidation in development and disease

STUDY_SECTION: MGB

STUDY_SECTION_NAME: Molecular Genetics B Study Section[MGB]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Childhood Leukemia;Gene Therapy;Genetics;Hematology;Human Genome;Immunotherapy;Pediatric;Pediatric Cancer;Rare Diseases

PHR: Narrative To improve T cell based immunotherapy, it is necessary to understand how the local metabolic milieu impedes the multiple-step process of target cell recognition and killing. We pursue a causal chain connecting three metabolic pathways to mitochondrial function and serial killing in chimeric antigen receptor (CAR) T cells. We will also determine the importance of extracellular fructose—which is upregulated in some tumor microenvironments—on tumor immune reactivity and response to immunotherapy.

PI_NAMEs: O'CONNOR, RODERICK  (contact)

PROGRAM_OFFICER_NAME: LIU, YIN

PROJECT_TERMS: Acute Myelocytic Leukemia;Adoptive Transfer;Advanced Malignant Neoplasm;Affect;Antigens;Arginine;argininosuccinate synthase;Aspartate;ATAC-seq;Biological Assay;Bone Marrow;CD28 gene;cell motility;Cell Physiology;Cells;Cellular immunotherapy;chimeric antigen receptor;chimeric antigen receptor T cells;Citrates;Clinical;conditioning;cost;Coupling;Cytolysis;Cytoplasm;Cytotoxic T-Lymphocytes;cytotoxicity;Data;design;electric impedance;Enzymes;Epigenetic Process;Equilibrium;Event;experimental study;extracellular;Family;fitness;Fructose;Fumarates;Genes;genetic approach;Genetic Transcription;Genus Hippocampus;Glucose;Glutamine;Goals;Human;Hypoxia;IL3RA gene;Image;Imaging technology;Immune;Immunotherapy;improved;In Vitro;in vitro Model;in vivo;Infrastructure;Infusion procedures;innovation;insight;Link;Malignant Neoplasms;matrigel;Mediating;Metabolic;Metabolic Pathway;Metabolism;migration;Mitochondria;mitochondrial metabolism;Modeling;multiple omics;neoplastic cell;normoxia;Nutrient;Outcome;overexpression;Oxaloacetates;Pathway interactions;Patients;Penetration;Phenotype;Process;Production;Receptor Signaling;Regimen;Research;resilience;Resources;respiratory;response;Running;Signal Transduction;Solid Neoplasm;Source;stable isotope;Stable Isotope Labeling;Supporting Cell;Synapses;synaptogenesis;synergism;T-Lymphocyte;Technology;Testing;Therapeutic;Time;Training;Transaminases;transcriptome sequencing;tumor;tumor hypoxia;tumor microenvironment;Work

PROJECT_TITLE: What fuels CAR T-cell serial killing

STUDY_SECTION: CIC

STUDY_SECTION_NAME: Cellular Immunotherapy of Cancer Study Section[CIC]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Biotechnology;Cancer;Contraception/Reproduction;Genetics;Infertility;Ovarian Cancer;Prevention;Rare Diseases;Women's Health Research

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: NARRATIVE Our studies are directly relevant to the missions of the National Institute of Child Health and Human Development and, in particular, research into reproduction, contraception, and population control because transforming growth factor β (TGFβ) superfamily signaling pathways play essential roles in a diversity of developmental and pathophysiological processes including reproductive disorders. Our studies will improve the reproductive health of women, better the quality-of-life of women and their offspring, improve the diagnosis and treatment of reproductive health conditions, including infertility, endometriosis, and preeclampsia, and advance the development of better contraceptive therapies for women. The objectives of this R01 renewal are to mechanistically define the TGFβ family-SMAD-mediated signaling in the ovary, during pregnancy and in maternal diseases and to uncover new drugs for interrogating the functions of BMPs, activins, myostatin, and GDF11 for treatments of clinically important reproductive and non-reproductive diseases.

PI_NAMEs: MATZUK, MARTIN M. (contact)

PROGRAM_OFFICER_NAME: JOHNSTON, DANIEL STEPHEN

PROJECT_TERMS: Acceleration;Activin A type II receptor;Activin Receptor;Activins;Address;Advanced Development;Affinity;antagonist;Award;Binding;Binding Proteins;Biochemical;Biology;BMP15 gene;bone loss;bone morphogenetic protein receptors;Cachexia;Cell Nucleus;Cell secretion;cell type;Cells;Chemicals;Chemistry;Clinic;Clinical Treatment;Complex;Contraceptive Agents;Contraceptive methods;CRISPR/Cas technology;Defect;Development;Diagnosis;dimer;Disease;DNA;DNA Sequence;Endometrial Hyperplasia;endometriosis;Event;Family;Family member;female fertility;female reproductive tract;Fertility;Fetal Growth Retardation;field study;folliculogenesis;Follistatin;follow-up;Functional disorder;Funding;GDF11 gene;GDF8 gene;Genes;Genetic;Genetic Transcription;Genomics;Germ Cells;Germ Lines;Goals;Grant;granulosa cell;Growth Differentiation Factor 9;Human;implantation;improved;in vivo;Infertility;INHA gene;inhibin;Inhibin A;inhibitor;innovation;insight;Investigation;kinase inhibitor;Knock-out;Knockout Mice;Libraries;Ligands;Link;MADH2 gene;MADH3 gene;MADH4 gene;Malignant neoplasm of ovary;Mammals;Mediating;Medicine;Mission;Molecular;Molecular Mechanisms of Action;mouse genetics;mouse genome;mouse model;Mus;Muscle;Muscular Atrophy;National Institute of Child Health and Human Development;Nature;novel;novel therapeutics;offspring;Oocytes;Ovarian;Ovary;Paper;Pathway interactions;Pharmaceutical Preparations;Phosphorylation;Phosphotransferases;Physicians;Physiological;Physiology;Pituitary Gland;Play;Population Control;Pre-Eclampsia;Pregnancy;Pregnancy loss;Procedures;Process;Productivity;protein function;Protein Secretion;Proteomics;Publishing;Pulmonary Hypertension;Quality of life;receptor;Receptor Serine/Threonine Kinase;Receptor Signaling;Recurrence;Regulation;Reproduction;reproductive;Reproductive Health;reproductive system disorder;reproductive tract;Research;Role;Science;Scientist;secondary infertility;Secondary to;Signal Pathway;Signal Transduction;Smad Proteins;small molecule;small molecule inhibitor;small molecule libraries;Somatic Cell;Specificity;Study models;Syndrome;Technology;TGF-beta type I receptor;Time;tool;Transforming Growth Factor beta;Translational Research;Tumor Suppressor Proteins;Uterus;Woman;women's reproductive health

PROJECT_TITLE: Transforming growth factor β family signaling pathways in ovarian and uterine biology

STUDY_SECTION: ICER

STUDY_SECTION_NAME: Integrative and Clinical Endocrinology and Reproduction Study Section[ICER]


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Neurosciences;Prevention;Rare Diseases

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: Narrative Dr. Kim is an active and vital leader in the clinical trials program at The University of Michigan Rogel Cancer Center whose extensive, collaborative work has supported the NCI clinical trials infrastructure institutionally and nationally. Her major contributions institutionally include serving as Co-Chair of the Neuro-Oncology Clinical Research Team, active member of the Cancer Center Protocol Review Committee, and nationally as the Co-Chair of the NIH/NCI Brain Metastases Interest Group and active member of the NRG Oncology and Alliance Brain Tumor Committees. Through this Research Specialist Award opportunity, she will grow her institutional and national leadership contributions in support of NCI clinical trials research.

PI_NAMEs: KIM, MICHELLE MIRAN (contact)

PROGRAM_OFFICER_NAME: TAWAB-AMIRI, ABDUL

PROJECT_TERMS: Address;Award;Awareness;Brain Neoplasms;Cancer Center;Clinical Research;Clinical Trials;Collaborations;Communities;Community Clinical Oncology Program;Development;Disease;Eligibility Determination;Event;Funding;Glioblastoma;Guidelines;imaging biomarker;Infrastructure;Institution;inter-institutional;Interest Group;Intervention;Intervention Trial;investigator-initiated trial;Journals;Lead;Leadership;Malignant neoplasm of central nervous system;medical specialties;member;Metastatic malignant neoplasm to brain;Metastatic Neoplasm to the Central Nervous System;Michigan;Minority;Mission;National Comprehensive Cancer Network;neuro-oncology;Newsletter;Oncology;participant enrollment;patient population;Patients;Phase;Phase II/III Trial;Population;Principal Investigator;Process;programs;Protocols documentation;Radiation therapy;Research;Research Personnel;Research Support;Review Committee;screening program;Site;Specialist;trial enrollment;tumor;United States National Institutes of Health;Universities;virtual;Woman;Work

PROJECT_TITLE: Dr. Kim R50 Research Specialist Clinician 2022


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Cannabinoid Research;Drug Abuse (NIDA only);Neurosciences;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Substance Misuse

ORG_CITY: WINSTON-SALEM

ORG_DEPT: NEUROSCIENCES

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE The legalization of cannabis products has led to an increase in the self-medication of medicinal marijuana by users who believe cannabis to be “perfectly safe”, notwithstanding the impact cannabis components have on neuronal development. This project explores the modulation of CB1 cannabinoid receptor (CB1R) by its cellular protein partner Cannabinoid Receptor Interacting Protein 1a (CRIP1a), a protein associated with defects in neurosensory development and schizophrenia. Understanding the biochemistry of CRIP1a and its interaction with and mechanism of regulation of CB1R is essential for understanding the impact of cannabis usage.

PI_NAMEs: HUGHES, ERIN K (contact)

PROGRAM_OFFICER_NAME: FALCON-MORALES, EDGARDO

PROJECT_TERMS: Address;Adolescence;Age;Agonist;antagonist;Antibodies;Binding;Binding Proteins;Biochemical;Biochemistry;Biological;Brain region;C-terminal;cannabinoid receptor;cannabinoid receptor interacting protein 1a;Cannabis;career development;Cell model;Cells;Central Nervous System;child bearing;CNR1 gene;Collaborations;Complex;Cytoplasm;Data;Defect;Development;Dissociation;endogenous cannabinoid system;experimental study;Family member;farnesylation;Fluorescence Polarization;G Protein-Coupled Receptor Signaling;G-Protein-Coupled Receptors;GTP Binding;GTP-Binding Proteins;Heterotrimeric G Protein Subunit;Heterotrimeric GTP-Binding Proteins;Homologous Gene;Human;Immunoprecipitation;inhibitor;innovation;interest;Intracellular Transport;Knowledge;Legal;Ligands;Lipids;marijuana legalization;marijuana use;marijuana user;Mediating;Medical Marijuana;Membrane;migration;Molecular;Molecular Conformation;Monomeric GTP-Binding Proteins;Mus;myristoylation;N-terminal;nerve stem cell;neural;neuroblastoma cell;neuron development;Neurons;Neuropharmacology;neurosensory;neurotransmitter release;novel;palmitoylation;Pathway interactions;Peptides;Persons;Process;protein activation;protein complex;Protein Farnesylation;Protein Isoprenylation;Protein Subunits;Proteins;receptor;receptor function;Receptor Signaling;Regulation;Research Personnel;Resolution;response;Role;Safety;Schizophrenia;Self Medication;Signal Transduction;stem cell proliferation;Structure;synaptogenesis;Testing;Tetrahydrocannabinol;Time;Training;X-Ray Crystallography

PROJECT_TITLE: Cannabinoid Receptor Interacting Protein 1a (CRIP1a) in cell signaling and cargo transport

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-Q(20)L]


NIH_SPENDING_CATS: Diabetes

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: The proposed research is relevant to public health because the discovery that FFA4 stimulation improves beta cell function by a combination of delta cell-dependent and beta cell-autonomous mechanisms represent additive or synergistic ways to leverage local feedback as a novel way to treat patients with type 2 diabetes. Moreover, these mechanism complement existing treatment paradigms. Thus the proposed research is relevant to NIDDK's mission because it directly addresses a critical unmet need to improve the health and quality of life of the millions of Americans with diabetes.

PI_NAMEs: HUISING, MARK O. (contact);POITOUT, VINCENT

PROGRAM_OFFICER_NAME: HWA, ALBERT J

PROJECT_TERMS: Ablation;Address;Adult;Agonist;American;B Cell Proliferation;B-Lymphocytes;Beta Cell;Cell Physiology;Cell Proliferation;cell type;Cells;Complement;Coupled;Couples;Cyclic AMP;D Cells;Data;diabetes management;Diabetes Mellitus;diabetes mellitus therapy;Disease;Disease Management;Drug Targeting;experimental study;Feedback;Functional Imaging;G-Protein-Coupled Receptors;Gases;Generations;Genetic;Glucagon;Goals;GTP-Binding Proteins;Half-Life;Health;Hormone secretion;Hormones;improved;innovation;Insulin;Insulin deficiency;Insulin Resistance;insulin secretion;Interruption;islet;Islet Cell;Islets of Langerhans;Kinetics;Laboratories;long chain fatty acid;Mediating;mimetics;Mission;National Institute of Diabetes and Digestive and Kidney Diseases;new therapeutic target;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutics;Pancreas;pancreatic islet function;paracrine;Pathway interactions;Patients;Peripheral;Pharmaceutical Preparations;pharmacologic;Physiological;Prediabetes syndrome;preservation;programs;Proliferating;Protein Isoforms;Protein Subunits;Public Health;Publishing;Quality of life;receptor;Regulation;Research;Research Proposals;Resolution;response;Role;Signal Transduction;Small Interfering RNA;Somatostatin;targeted treatment;Testing;Therapeutic Intervention;therapeutic target;Toxin;Validation

PROJECT_TITLE: FFA4 regulation of pancreatic islet function


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Cancer Genomics;Genetics;Human Genome;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation;Women's Health Research

ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: PROJECT NARRATIVE  Proper control of the activity of resident stem/progenitor cells is important for building or regenerating a functional tissue. Too much self-renewal and proliferation may cause cancer, whereas failure to maintain stem/progenitor cells or undergo terminal differentiation will result in the inability to generate or sustain the desired tissue and lead to diseases. The proposed studies will help us understand how tissue epithelial stem/progenitor cell activities are regulated by factors within and outside of the stem cells, and may implicate new knowledge of cancer cell dormancy and molecular targets for treating diseases such as breast cancer.

PI_NAMEs: DAI, XING  (contact)

PROGRAM_OFFICER_NAME: SALAZAR, DESIREE LYNN

PROJECT_TERMS: Address;Basal Cell;beta catenin;Biological Models;cancer cell;Cancer Etiology;Cell Compartmentation;cell type;Cells;Characteristics;Chromatin;clinically relevant;Disease;epithelial stem cell;Epithelium;Event;Failure;Gene Expression;Gene Expression Regulation;Genetic Transcription;Heterogeneity;Homeostasis;in vivo;innovation;insight;interdisciplinary approach;knockout gene;Knowledge;Macrophage;Malignant Breast Neoplasm;mammary;mammary epithelium;Mammary gland;Maps;Mesenchymal;Molecular;Molecular Target;Morphogenesis;Natural regeneration;novel;prevent;programs;Proliferating;Prostate;regenerative;Regenerative Medicine;Regulation;Research;self-renewal;Signal Pathway;Signal Transduction;single cell genomics;single cell sequencing;Skin;Stem Cell Assay;stem cell biology;stem cell exhaustion;stem cell genes;stem cells;Technology;Testing;Tissue Engineering;tissue regeneration;tissue stem cells;Tissues;Undifferentiated

PROJECT_TITLE: Intrinsic and extrinsic control of epithelial tissue stem cell activity

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Pediatric;Pediatric Cancer;Prevention;Rare Diseases;Rehabilitation;Social Determinants of Health;Telehealth

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: In response to the RFA-CA-20-027, we propose to conduct a Type 1 hybrid effectiveness-implementation trial to assess the effectiveness of a 4-session synchronous digital health insurance navigation intervention compared to 1) enhanced usual care and 2) an asynchronous delivery of the digital health insurance navigation intervention in promoting health insurance literacy among 520 survivors from the Childhood Cancer Survivor Study (survivors diagnosed before the age of 21). A rigorous implementation evaluation will be conducted, which will leverage our objective to establish a sustainable intervention to improve health outcomes of childhood cancer survivors through enhanced health insurance literacy and decreased financial hardship.

PI_NAMEs: KIRCHHOFF, ANNE C;PARK, ELYSE R. (contact)

PROGRAM_OFFICER_NAME: MOLLICA, MICHELLE A

PROJECT_TERMS: 21 year old;Acute;Address;Adherence;Adolescent and Young Adult;Adult;Affordable Care Act;Age;Area;Awareness;barrier to care;Behavioral Model;Cancer Survivor;Caring;Characteristics;Child health care;Childhood;childhood cancer survivor;Childhood Cancer Survivor Study;Chronic;cohort;Cohort Studies;comparison intervention;Complex;cost;cost effective;Data Collection;deprivation;design;Diagnosis;digital;digital delivery;digital health;digital intervention;effectiveness evaluation;effectiveness/implementation trial;Ensure;Ethnic Origin;experience;Face;Financial Hardship;follow-up;Health;Health Care Costs;Health Care Reform;health care service;health care service utilization;Health Insurance;Health Promotion;health service use;Health Services Accessibility;Healthcare;Healthcare Systems;implementation evaluation;implementation intervention;improved;indexing;innovation;Insurance;Insurance Benefits;Insurance Coverage;Intervention;intervention delivery;intervention effect;Knowledge;literacy;Long-Term Effects;Malignant Neoplasms;Medicaid;Medical Care Costs;Medical History;Medical Surveillance;Methods;mHealth;Monitor;Morbidity - disease rate;Outcome;Pamphlets;patient navigation;patient navigator;patient portal;Patients;Pharmaceutical Preparations;Policies;prevent;primary outcome;psychoeducation;Race;Randomized;randomized trial;Recommendation;Recording of previous events;recruit;Research;response;Risk;Sampling;screening;secondary outcome;Siblings;skills;sociodemographics;Survivors;survivorship;synchronous contact;synchronous delivery;Testing;three-arm trial;tool;treatment as usual;trial comparing;Underinsured;Uninsured Medical Expense;virtual;Visit

PROJECT_TITLE: Assessing the effect of virtual navigation interventions to improve health insurance literacy and decrease financial burden:  A CCSS randomized trial


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Mental Health;Neurosciences

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: PROJECT NARRATIVE  We propose to conduct transformative research aimed at elucidating the fundamental neural mechanisms underlying functional brain organization, connectivity and global brain dynamics. Our studies will bridge critical gaps in our knowledge by linking non-invasive fMRI measurements with its underlying cellular and neural-circuit organization. The proposed studies have significant public health impact as they focus on cognitive control circuits impacted in a wide range of brain disorders, which calls for innovative integrated experimental and computational approaches to the understanding of brain function and dysfunction. 1

PI_NAMEs: MENON, VINOD ;SHIH, YEN-YU IAN (contact)

PROGRAM_OFFICER_NAME: ROSSI, ANDREW F

PROJECT_TERMS: Address;Alzheimer's Disease;Anterior;Area;Attention;Attention deficit hyperactivity disorder;Attenuated;Auditory;autism spectrum disorder;awake;Behavior;Behavioral;Brain;Brain Diseases;Brain region;causal model;cell type;cingulate cortex;cognitive control;Data;deviant;Disinhibition;Entropy;Event;excitatory neuron;Exhibits;Fiber;Frequencies;Functional disorder;Functional Magnetic Resonance Imaging;Goals;hemodynamics;Human;Image;indexing;inhibitory neuron;innovation;insight;Insula of Reil;Interneurons;Investigation;Knowledge;Link;Magnetic Resonance Imaging;Measurement;Measures;Medial;Methodology;Mus;Nervous System Disorder;network architecture;network dysfunction;neural circuit;neuromechanism;Neurons;neurophysiology;neuropsychiatric disorder;neuropsychiatry;new technology;novel;optogenetics;Output;Phase;Photometry;Prefrontal Cortex;prevent;Public Health;Repetitive Sequence;Research;response;Rest;Rodent;Schizophrenia;Signal Transduction;Space Models;Stimulus;Stress;Study models;System;Techniques;Time;time use;Translational Research;Translations

PROJECT_TITLE: Circuit Mechanisms Governing the Default Mode Network

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


ADMINISTERING_IC: ES

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cardiovascular;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Social Determinants of Health

ORG_DEPT: MISCELLANEOUS

PHR: NARRATIVE Cardiovascular disease (CVD), the leading cause of death in the U.S., disproportionately impacts persons of lower socioeconomic position (SEP) -- a disparity that has been attributed to heightened exposures to both traffic- related air pollution (TRAP) and chronic social stressors, in communities of lower SEP. We will test the hypotheses that: (1) TRAP composition (light- vs. heavy-duty vehicles) differentially influences cardiovascular function; (2) chronic stress may heighten animals’ cardiovascular response to TRAP; and (3) TRAP may compromise animals’ cardiovascular resilience to stress challenge. Using animal models to separate these synergies, we will directly inform on biologically-grounded epidemiologic model structure, realistic space-time exposure measures for both stress and pollution, and help guide policy towards identifying susceptible populations, improving health, clarifying safe air pollution concentrations, and reducing health disparities.

PI_NAMEs: CHEN, CHAO-YIN ;CLOUGHERTY, JANE ELLEN;WEXLER, ANTHONY STEIN (contact)

PROGRAM_OFFICER_NAME: NADADUR, SRIKANTH

PROJECT_TERMS: Acute;acute stress;Address;African American population;Air;air filter;Air Pollution;American;Animal Model;Animals;atmospheric sciences;Biological;biological adaptation to stress;Biological Markers;Blood Pressure;Bronchoalveolar Lavage Fluid;Cardiovascular Diseases;cardiovascular health;Cardiovascular Physiology;Cardiovascular system;Cause of Death;Chemicals;Chronic;Chronic stress;Circulation;Communities;Complex;cytokine;design;Disparity;Duct (organ) structure;effective intervention;Electrocardiogram;Endocrine;Engineering;Environmental Epidemiology;environmental health disparity;environmental justice;Environmental Pollution;epidemiological model;Epidemiology;ethnic health disparity;exhaust;Exposure to;Gases;Health;health disparity;Human;Hydrocortisone;hypothalamic-pituitary-adrenal axis;Immune;improved;In Vitro;Inflammation;Intervention;Lead;Light;Literature;low socioeconomic status;Maps;marginalized community;Measures;Mechanics;Mediating;Metabolic;Modeling;Oxidative Stress;particle;Particle Size;Pathway interactions;Persons;Physiological;Policies;Pollution;Population;Poverty;Predisposition;racial health disparity;Rattus;Reduce health disparities;Regulation;Research Personnel;resilience;response;restraint stress;Risk;Rodent;Role;Science;scientific atmosphere;Shapes;social;social stressor;Sprague-Dawley Rats;stem;Stress;Structure;synergism;System;Telemetry;Testing;Time;time use;Tissues;traffic-related air pollution;underserved community;United States National Institutes of Health;Violence;Vulnerable Populations;Work

PROJECT_TITLE: Synergistic Effects of Stress and Traffic-Related Air Pollution on Cardiovascular Health


ADMINISTERING_IC: EB

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cardiovascular;Clinical Research;Hypertension;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention

ORG_CITY: LA JOLLA

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE Central blood pressure is proven to be more valuable for cardiovascular disease management than the blood pressure commonly measured on the arm. However, current approaches for measuring central blood pressure are limited by either invasiveness, inaccuracy, or intermittency. This research project aims to develop a fully- integrated wearable ultrasonic device that allows automatic monitoring of central blood pressure in a noninvasive, accurate, and continuous manner.

PI_NAMEs: XU, SHENG  (contact)

PROGRAM_OFFICER_NAME: KING, RANDY LEE

PROJECT_TERMS: Acoustics;Address;Algorithms;Anterior;Anti-Hypertensive Agents;arm;Arteries;automated algorithm;Automatic Data Processing;Awareness;Benchmarking;Blood Pressure;blood pressure control;Blood Pressure Monitors;blood pressure reduction;Blood Vessels;Bluetooth;Cardiology;Cardiovascular Diseases;cardiovascular disorder prevention;cardiovascular risk factor;Cardiovascular system;Catheterization;Catheters;Cellular Phone;Clinical;clinical practice;clinically relevant;Collaborations;computerized data processing;Consumption;Data;data exchange;Data Set;deep learning;deep learning algorithm;Dependence;design;Development;Devices;Diagnosis;Diameter;disorder risk;Electronics;Elements;Evaluation;Event;Fourier Analysis;Frequencies;Future;General Population;Grant;Health;Health Care Costs;high throughput screening;Hour;Human;human error;human subject;Hypertension;hypertension control;hypertension treatment;Image;Immobilization;improved;Intervention;invention;Label;Location;Machine Learning;machine learning algorithm;Manuals;Maps;Measurement;Measures;Methods;miniaturize;Modeling;Monitor;monitoring device;mortality;multidisciplinary;Noise;non-invasive monitor;operation;optical fiber;Outcome;Participant;Patients;Performance;Peripheral;peripheral blood;Phase;Photoplethysmography;Physics;Physiologic pulse;Polymers;power consumption;prehypertension;printed circuit board;Procedures;Process;Research;Research Project Grants;Resolution;Risk Assessment;Risk Management;Running;Safety;screening;Series;Shapes;Side;Signal Transduction;skills;Skin;standard of care;Statistical Data Interpretation;Supervision;Surface;Symptoms;System;Systems Integration;Techniques;Technology;Time;tonometry;Training;Transducers;Translating;Ultrasonic Transducer;Ultrasonics;ultrasound;United States National Institutes of Health;usability;Validation;wearable device;wearable platform;wireless;wireless data transmission;wireless transmission;Work

PROJECT_TITLE: A Wearable Ultrasonic System for Automatic, Continuous, and Noninvasive Monitoring of Central Blood Pressure

STUDY_SECTION: ITD

STUDY_SECTION_NAME: Imaging Technology Development Study Section[ITD]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: A central goal of neurobiology is to reveal how the brain generates and organizes action, but we lack sophisticated tools for objectively and comprehensively characterizing behavior. We have developed a next- generation method called Motion Sequencing (MoSeq) that affords unprecedented insight into how the brain organizes behavior; however, using this approach requires substantial expertise, which has slowed its adoption by the scientific community. Here we propose to streamline and package the underlying code, and to offer hands-on training, so that users without extensive computer science or math backgrounds can easily use MoSeq to characterize animal behavior as part of efforts to understand how genes, drugs or neural activity changes action.

PI_NAMEs: DATTA, SANDEEP R (contact)

PROGRAM_OFFICER_NAME: TRZCINSKI, NATALIE KATHERINE

PROJECT_TERMS: 3-Dimensional;Acceleration;Adoption;Animal Behavior;Animals;awake;Behavior;Behavior assessment;behavior measurement;Behavioral;Brain;Calcium;cell type;Cloud Computing;Code;Collaborations;Collection;Communities;Complex;computer science;Computer software;Corpus striatum structure;Coupling;Data;data format;Data Storage and Retrieval;Dedications;Democracy;design;Educational workshop;Elements;experience;experimental study;flexibility;Gene Expression;Genes;Goals;graduate student;graphical user interface;Head;Imaging technology;improved;Individual;inhibitor;innovation;insight;Instruction;Knowledge;Learning;machine learning algorithm;machine vision;Mathematics;Measures;Methods;Modeling;Modernization;Motion;Mus;natural language;Nervous System;Nervous System Physiology;neural;neural circuit;neurobehavioral;Neurobiology;neuronal circuitry;Neurosciences;next generation;open source;Output;Pattern;Persons;Pharmaceutical Preparations;Population;Posture;Procedures;Proliferating;Pythons;Reporting;Resolution;Rodent;sample fixation;skills;Stereotyping;Structure;System;Techniques;Technology;Technology Assessment;tool;Training;unsupervised learning;Validation;voltage;web services;Work;Writing

PROJECT_TITLE: Motion Sequencing for All: Pipelining, Distribution and Training to Enable Broad Adoption of a Next-Generation Platform for Behavioral and Neurobehavioral Analysis


NIH_SPENDING_CATS: Genetics;Infectious Diseases

PHR: PROJECT NARRATIVE Systemic candidiasis, mainly caused by the opportunistic yeast Candida albicans, is the fourth leading cause of nosocomial bloodstream infection in the US and worldwide. The innate immune response is critical for host defense against invasive candidiasis. This application aims to determine C. albicans proteins that govern Candida-immune cell interaction and Candida pathogenesis.

PI_NAMEs: LIU, HAOPING  (contact)

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TERMS: Acetyltransferase;Agriculture;Air;alpha ketoglutarate;Animal Model;Attenuated;Beta-N-Acetylglucosaminidase;Binding;Biology;C-terminal;Candida;Candida albicans;Candidiasis;Carbon Dioxide;Cell Communication;Cells;ChIP-seq;Chromatin;chromatin remodeling;commensal microbes;Cues;Cyclic AMP;Cyclic AMP-Dependent Protein Kinases;Data;Development;Dioxygenases;Disease;Disseminated candidiasis;Down-Regulation;Environment;Foundations;fungus;Gastrointestinal tract structure;Genes;Genetic Transcription;genome-wide;Goals;Hematogenous;Histone Acetylation;Host Defense;human pathogen;Hypercapnia;Hyphae;Hypoxia;Immune;Infection;Innate Immune Response;insight;Investigation;Laboratories;Link;Macrophage;Maintenance;Mediating;Medical;Mitogen-Activated Protein Kinases;Molecular;Morphogenesis;mucosal site;mutant;N-terminal;Nitric Oxide;novel;novel therapeutic intervention;NRG1 gene;Nutrient;Oxygen;Pathogenesis;pathogenic fungus;Pathogenicity;Pathway interactions;Phagosomes;Phase;Phosphorylation;Physiological;Procollagen-Proline Dioxygenase;programs;promoter;Protein Dephosphorylation;protein phosphatase 2C;Proteins;Regulation;response;sensor;Sepsis;Signal Pathway;Signal Transduction;Stress;Transcription Coactivator;transcription factor;Transcription Repressor;transcriptome sequencing;Virulence;Yeasts

PROJECT_TITLE: Signal sensing, hyphal development and pathognesis of Candida albicans

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDM-M(02)M]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Eye Disease and Disorders of Vision;Mental Health;Neurosciences

ORG_CITY: BALTIMORE

ORG_DEPT: PSYCHOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative Social interaction recognition is central to humans’ daily lives and highly relevant to NIMH as the ability to perceive and interpret social interactions is characteristically disrupted in autism. Despite its ubiquity and clinical relevance, the brain basis of social interaction recognition remains poorly understood. The proposed research will 1) uncover the neural computations underlying different aspects of social interaction recognition (from visual to high-level), and 2) formalize large-scale studies of social interaction recognition, paving the way for a rigorous examination of these abilities in typical and atypical development.

PI_NAMEs: ISIK, LEYLA  (contact)

PROGRAM_OFFICER_NAME: BREEDEN, ANDREW LEE

PROJECT_TERMS: Adult;autism spectrum disorder;Behavioral;Brain;Brain region;clinically relevant;Clip;Code;cognitive process;Complex;Computer Models;Coupled;Cues;Data;Data Set;design;Detection;Development;Electroencephalography;Emotional;Evaluation;experimental study;Functional Magnetic Resonance Imaging;Goals;graph neural network;Human;insight;Label;Life;Measures;Methodology;Modeling;Motion;multimodality;National Institute of Mental Health;neural;Neural Network Simulation;neuroimaging;novel;Pattern Recognition;Perception;Persons;Process;Psyche structure;Research;response;Role;simulation;social;Social Hierarchy;Social Interaction;Stimulus;Structure of superior temporal sulcus;Testing;theories;theory of mind;Visual;visual information;Visual Pathways;visual processing;Work

PROJECT_TITLE: The neural computations underlying human social interaction recognition

STUDY_SECTION: HCMF

STUDY_SECTION_NAME: Human Complex Mental Function Study Section[HCMF]


NIH_SPENDING_CATS: Complementary and Integrative Health;Natural Products

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

PHR: PROJECT NARRATIVE Natural products have traditionally served as platforms for the establishment of medicinal chemistry programs and as sources of inspiration for organic chemistry research. This proposal aims to invent methods enabling the synthesis of terpene and alkaloid scaffolds, as well as other complex molecules of relevance to the pharmaceutical industry. These methods will benefit scientists in a variety of academic and industrial settings owing to their mildness, efficiency, low cost, versatility and practicality.

PI_NAMEs: BARAN, PHIL S (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TITLE: Scalable Synthesis and New Bond Disconnections

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-P(55)R]


ADMINISTERING_IC: EY

ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Eye Disease and Disorders of Vision;Neurosciences;Rehabilitation;Stroke

ORG_CITY: ROCHESTER

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: The proposed work examines changes in plastic potential of the visual system with time from stroke affecting primary visual cortex. We will measure structural and mechanistic aspects of progressive degeneration along the early visual pathways, correlating them with changes in visual performance and responsiveness to visual restoration training in the blind field. This project will advance both scientific knowledge, as well as technical capability and clinical practices for restoring vision and quality of life for people suffering from cortical blindness.

PI_NAMEs: HUXLIN, KRYSTEL R (contact)

PROGRAM_OFFICER_NAME: WIGGS, CHERI

PROJECT_TERMS: Adult;Affect;Animal Model;area striata;Attention;blind;Blindness;brain magnetic resonance imaging;Cell Death;Chronic;clinical practice;Complex;Contralateral;Cortical Blindness;cost;Cues;Data;Discrimination;discrimination task;Dorsal;early onset;effective therapy;expectation;gaze;Goals;Grant;Hemianopsia;Human;human model;Image;Impairment;improved;insight;Intervention;Knowledge;Lateral Geniculate Body;Leadership;Link;Location;luminance;Magnetic Resonance Imaging;Measurable;Measures;Methods;Motion;Motor Cortex;Neurons;Noise;novel;Optic tract structure;Optical Coherence Tomography;Outcome;Participant;patient population;Patients;Perception;Perceptual learning;Persons;Physical therapy;post stroke;preservation;Property;Psychological Transfer;Psychophysics;Quality of life;Randomized;Recovery;Research;Residual state;restoration;Retina;Retinal Ganglion Cells;Retrograde Degeneration;sight restoration;Stimulus;Stroke;stroke rehabilitation;Testing;Time;Training;Unconscious State;Vision;Visual;visual discrimination;Visual Pathways;visual performance;visual plasticity;Visual System;Work

PROJECT_TITLE: Vision recovery in cortical blindness

STUDY_SECTION: CP

STUDY_SECTION_NAME: Cognition and Perception Study Section[CP]


NIH_SPENDING_CATS: Neurosciences;Social Determinants of Health

ORG_CITY: LEXINGTON

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: Project Narrative The goal of the University of Kentucky Neuroscience Postbaccalaureate Research Education Program (UKNeu-PREP) is to serve individuals from underrepresented and disadvantaged backgrounds from under- graduate institutions without substantive research opportunities. The realization of this mission is the develop- ment of a diverse pool of well-trained postbaccalaureate participants that transition into strong, neuroscience and research-focused higher degree doctoral programs. A diverse scientific community and workforce are vital for increasing the quality of higher education, medicine (including reducing health care disparities), scientific research, and technological innovation to solve health-related problems and challenges.

PI_NAMEs: BRADLEY, LUKE H;GENSEL, JOHN C (contact)

PROGRAM_OFFICER_NAME: MATTHEWS, MARGUERITE

PROJECT_TERMS: Address;Admission activity;African American;American;Appalachian Region;Appointment;Biological Sciences;Biomedical Research;career;central nervous system injury;Communication;Communities;Degree Completion;Development;Disabled Persons;Disadvantaged;disadvantaged background;Discipline;Doctor of Philosophy;Doctor's Degree;economic disparity;Education;education research;Educational process of instructing;Educational workshop;Electronic Mail;Employment;empowerment;Enrollment;Ensure;Environment;ethnic minority;expectation;experience;Exposure to;First Generation College Students;Foundations;Generations;Goals;graduate school;graduate school preparation;graduate student;Health;health care disparity;higher education;improved;Individual;innovation;Institution;Kentucky;Knowledge;Knowledge acquisition;Letters;Low income;Medicine;meetings;Mentors;Minority;Mission;Modeling;Neurobiology;Neurosciences;Neurosciences Research;Outcome;Output;Participant;Pathway interactions;Patient Recruitments;peer;people of color;Population;Positioning Attribute;Postbaccalaureate;Postdoctoral Fellow;Preparation;Process;programs;Publications;Qualifying;racial minority population;recruit;Recruitment Activity;Research;Research Training;Resources;role model;Scholars Program;Schools;Science;Scientist;skills;social;social media;Solid;Source;spinal cord and brain injury;stem;STEM career;Students;success;Surveys;symposium;Talents;technological innovation;Telephone;Training;Training and Infrastructure;Training Programs;undergraduate student;Underrepresented Minority;Underrepresented Populations;Underrepresented Students;Universities;university student;Videoconferencing;Woman;Work

PROJECT_TITLE: UKNeu-PREP: University of Kentucky Neuroscience Postbaccalaureate Research Education Program