NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Genetics;HIV/AIDS;Infectious Diseases;Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Neurosciences;Pediatric;Pediatric - AIDS;Social Determinants of Health

ORG_CITY: SAINT LOUIS

ORG_DEPT: NEUROLOGY

ORG_NAME: WASHINGTON UNIVERSITY

PHR: PROJECT NARRATIVE A substantial proportion of people with HIV experience cognitive impairment, despite effective multi-drug regimens targeting viral replication. This study will use DNA methylation profiling, magnetic resonance imaging, and machine learning methodology to investigate whether HIV infection and resulting cognitive impairment are associated with accelerated biological aging both in the epigenome and in the structure of the brain. This approach will help to clarify the mechanisms underlying cognitive impairment in people with HIV and may lead to better prognosis and clinical care for at-risk individuals.

PI_NAMEs: PETERSEN, KALEN J. (contact)

PROGRAM_OFFICER_NAME: RAO, VASUDEV RAMACHANDRA

PROJECT_TERMS: accelerated epigenetic aging;Affect;Age;age acceleration;Aging;aging biomarker;aging brain;aging population;aging related;antiretroviral therapy;Award;Bioinformatics;Biological;Biological Aging;Biology of Aging;Blood;Blood specimen;Brain;brain magnetic resonance imaging;brain morphology;Cardiovascular Diseases;career;career development;Central Nervous System;Characteristics;Chronology;Classification;Clinical;clinical care;Cognition;cognitive function;cohort;comorbidity;Computer Models;Data;Data Set;deep neural network;deprivation;Development;DNA Methylation;DNA methylation profiling;Ensure;Epigenetic age;epigenetic clock;Epigenetic Process;epigenome;epigenomics;Etiology;Exhibits;experience;Goals;gradient boosting;Grant;gray matter;Health;HIV;HIV Infections;HIV-associated cognitive impairment;imaging biomarker;Impaired cognition;improved;improved outcome;Individual;Infection;Inflammation;insight;Instruction;Knowledge;Laboratories;Leadership;Learning;Life;Life Expectancy;Link;Longevity;Machine Learning;machine learning method;machine learning prediction;Magnetic Resonance Imaging;Measures;Mediator;Mentorship;Methods;Modeling;Molecular and Cellular Biology;multidisciplinary;Neighborhoods;neural network;Neural Network Simulation;neuroAIDS;Neurobehavioral Manifestations;neuroimaging;Neuropsychological Tests;Neuropsychology;novel;Older Population;Outcome;Participant;Pathogenesis;pathological aging;Pattern;Persons;Pharmaceutical Preparations;Population;Population Heterogeneity;predictive modeling;Productivity;Prognosis;Quality of life;Regimen;Research;research study;Residual state;responsible research conduct;Risk;Risk Factors;Role;Seminal;skills;social;social health determinants;Speed;Structure;success;Techniques;Testing;tool;Training;Validation;Viral;Viral Load result;Virus Replication;Vulnerable Populations;Writing

PROJECT_TITLE: BIOLOGICAL AGING AND COGNITIVE IMPAIRMENT IN PERSONS WITH HIV

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


ADMINISTERING_IC: AI

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Brain Disorders;HIV/AIDS;Infectious Diseases;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Substance Misuse

ORG_CITY: PHILADELPHIA

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PHARMACOLOGY

ORG_FIPS: US

ORG_NAME: DREXEL UNIVERSITY

ORG_STATE: PA

PHR: Project Narrative  Effective diagnosis and treatment of substance use disorders in people living with HIV is a critical public health issue as these disorders are disproportionately prevalent in this vulnerable population, enhancing HIV neuropathogenesis and promoting behaviors that spread HIV. The cause of the change in neuropathogenesis is not clear, but we hypothesize that addictive substances enhance HIV neuropathogenesis by increasing dopamine, which drives inflammation in macrophages. In this F30, we will address this hypothesis by defining the mechanisms driving dopamine mediated inflammation in macrophages, which will give the candidate, Ms. Breana Channer, a comprehensive set of technical and professional skills that provide a robust foundation on which to prepare for a career as an independent physician scientist studying the neuroimmunology of HIV.

PI_NAMEs: CHANNER, BREANA  (contact)

PROGRAM_OFFICER_NAME: LAWRENCE, DIANE M

PROJECT_TERMS: Acceleration;Acute;Adrenergic Receptor;Age;American;antagonist;antiretroviral therapy;Automobile Driving;Behavior;Binding;Brain;calmodulin-dependent protein kinase II;career;Catecholamine Receptors;Categories;Cells;Cellular Morphology;Central Nervous System;Clustered Regularly Interspaced Short Palindromic Repeats;comorbidity;cost;CRISPR/Cas technology;CXCL10 gene;Cyclic AMP;cytokine;Data;Development;Diagnosis;Disease;Dopamine;Dopamine Antagonists;Dopamine D1 Receptor;Dopamine Receptor;Economics;Exposure to;extracellular;Foundations;Functional disorder;G-Protein-Coupled Receptors;glycogen synthase kinase 3 beta;Health;Health Benefit;HIV;HIV Infections;Human;human model;Image;Immune;immune function;immunoregulation;In Vitro;in vitro Model;Individual;induced pluripotent stem cell;Infection;Inflammasome;Inflammation;Inflammatory;inhibitor;Interleukin-1 beta;Interleukin-6;knock-down;Macrophage;Mediating;Modeling;Molecular;Monitor;monocyte;Myeloid Cells;neuroAIDS;neuroimmunology;neuroinflammation;Neurologic;Neuropathogenesis;NF-kappa B;Pathology;Pathway interactions;Persons;Pharmaceutical Preparations;pharmacologic;Phosphorylation;Physicians;Play;Pluripotent Stem Cells;Population;Process;Production;Proto-Oncogene Proteins c-akt;Public Health;Publishing;receptor;Receptor Activation;Resolution;Risk;Risk Behaviors;Risk Factors;Role;Scientist;Signal Pathway;Signal Transduction;skills;Stains;substance misuse;Substance Use Disorder;substance use treatment;Testing;Therapeutic;therapy adherence;Viral reservoir;Virus Diseases;Vulnerable Populations;Western Blotting

PROJECT_TITLE: Dopaminergic immunomodulation drives macrophage inflammation during HIV infection

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F17A-F (20)]


ADMINISTERING_IC: MH

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

ORG_CITY: NEW HAVEN

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Program Narrative Nearly 5000 new HIV infection occur per day, and the epidemic negatively impacting the most vulnerable populations resulting in health inequities, there remains a critical need to train investigators who are prepared to conduct primary and secondary prevention research in HIV. Our proposed Training Program will continue to provide the strongest foundation of knowledge, skills, professional networking and experience to young investigators at the pre- and post-doctoral levels, who can establish and sustain careers as scientific investigators, contributing to advances in HIV prevention, specifically, and health equity, in general.

PI_NAMEs: KERSHAW, TRACE S (contact)

PROGRAM_OFFICER_NAME: KAMATH, SUSANNAH M A

PROJECT_TERMS: AIDS prevention;Training Programs

PROJECT_TITLE: Interdisciplinary HIV Prevention Training Program

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-N (03)]


ADMINISTERING_IC: DC

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Assistive Technology;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Clinical Research;Disability Research;Hearing Loss;Pediatric;Prevention;Rehabilitation

ORG_CITY: BOYS TOWN

ORG_NAME: FATHER FLANAGAN'S BOYS' HOME

ORG_STATE: NE

PHR: NO CHANGES FROM ORIGINALLY AWARDED APPLICATION  PROJECT NARRATIVE Patients with hearing loss who use cochlear implants (CIs) show significant deficits and strong unexplained intersubject variability in their perception and production of spoken emotions in speech. This project will investigate the hypothesis that "cue-weighting", or how patients utilize the different acoustic cues to emotion, accounts for significant variance in emotional communication with CIs. The results will focus on children with CIs, but parallel measures in postlingually deaf adults with CIs will be made, ensuring that results of these studies benefit social communication by Cl patients across the lifespan by informing the development of technological innovations and improved clinical protocols.

PI_NAMEs: CHATTERJEE, MONITA  (contact)

PROGRAM_OFFICER_NAME: KING, KELLY ANNE

PROJECT_TERMS: Acoustics;Adult;Age;Auditory;Award;Birth;career networking;Characteristics;Child;Childhood;clinical development;Clinical Protocols;Cochlear Implants;Communication;Cues;deaf;Devices;Emotional;Emotions;Ensure;evidence base;experience;Hearing;hearing impairment;implantation;improved;Individual;individual patient;Knowledge;Language;Learning;life span;Link;Measures;Methodology;novel;Patient Self-Report;Patients;Pattern;Perception;Production;Quality of life;Research;Residual state;Risk Reduction;Shapes;social communication;Social Development;Social isolation;Social Network;Source;Speech;technological innovation;technology development;Testing;usability;Variant;Voice;Work

PROJECT_TITLE: Perception and Production of Emotional Prosody with Cochlear Implants


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Depression;Dissemination and Implementation Research;HIV/AIDS;Infectious Diseases;Major Depressive Disorder;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Mental Illness;Pediatric;Pediatric - AIDS;Pregnancy;Prevention;Serious Mental Illness;Women's Health Research

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE Perinatal depression is a barrier to sustained engagement in HIV care for women living with HIV (WLHIV) during the perinatal period, yet few interventions exist to address both mental health and engagement in HIV care outcomes. Building on our pilot trial, we will test in a randomized controlled trial the Enhanced Friendship Bench intervention, versus usual care, to improve perinatal depression and engagement in HIV care outcomes for WLHIV, as well as infant HIV, health, and developmental outcomes. Completion of the proposed project has strong potential to lead to a culturally appropriate, scalable counseling intervention to improve PND and engagement in HIV care outcomes for WLHIV that is poised for rapid translation into practice.

PI_NAMEs: BENGTSON, ANGELA ;PENCE, BRIAN W (contact)

PROGRAM_OFFICER_NAME: SENN, THERESA ELAINE

PROJECT_TERMS: Acceleration;Acquired Immunodeficiency Syndrome;Address;Affect;Africa South of the Sahara;antenatal;antepartum depression;antiretroviral therapy;arm;Breast Feeding;care outcomes;Caring;Child;Child Development;Clinic;clinical practice;compare effectiveness;comparison intervention;coping;Counseling;Data Collection;depressive symptoms;Development;effectiveness evaluation;effectiveness trial;efficacy evaluation;Epidemic;evidence base;Evidence based intervention;experience;Friendships;Funding;Goals;Growth;Health;Health Sciences;high risk;HIV;Human immunodeficiency virus test;hybrid type 1 design;implementation framework;implementation measures;implementation outcomes;implementation science;improved;Individual;Infant;Infant Health;Infrastructure;innovation;Intervention;intervention effect;intervention participants;intimate partner violence;Link;low and middle-income countries;Malawi;male;Mediating;Mediator;Mental Health;Methods;Modeling;Mothers;National Institute of Mental Health;Outcome;Participant;perinatal HIV;perinatal mental health;perinatal period;perinatal women;peripartum depression;Persons;pilot trial;Positioning Attribute;Post-Traumatic Stress Disorders;postnatal;Postpartum Depression;Postpartum Period;pregnant;Pregnant Women;prenatal;prenatal experience;primary outcome;problem solving therapy;Proctor framework;programs;Protocols documentation;Qualifying;randomized trial;Randomized, Controlled Trials;Research;Research Infrastructure;Resources;scale up;Severities;sex;social stigma;Social support;Subgroup;substance use;success;symptomatic improvement;Testing;Therapeutic;Translations;transmission process;treatment as usual;Viral;Viral Load result;Woman;Women's Health;women's outcomes;Work

PROJECT_TITLE: Enhanced problem-solving therapy and HIV engagement support to improve perinatal mental health and HIV outcomes in Malawi: A randomized controlled trial

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


ADMINISTERING_IC: VA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: Veterans Affairs

ORG_CITY: BEDFORD

ORG_NAME: EDITH NOURSE  ROGERS MEMORIAL VETERANS HOSPITAL

ORG_STATE: MA

PHR: Veteran access to an assessment of day-to-day function is vital to enable aging-in-place, especially for Veterans with dementia who experience progressive functional decline that necessitates caregiver assistance. While early assessment of Veteran day-to-day function is critical to mitigate the functional losses due to dementia, Veterans with dementia face barriers to a functional assessment due to rurality or difficulty traveling to the clinic. Though video telehealth increases access to care, video has not been used to observe daily life tasks, such as tooth-brushing or medication management, particularly for Veterans with dementia. This project will develop and pilot test an assessment of Veteran day-to-day function adapted for VA Video Connect (VVC). Increasing Veteran access to functional assessment allows clinicians to identify Veteran functional deficits and related need for caregiver assistance, thereby minimizing the cascading effects of dementia and disability- related deficits to Veterans, caregivers, and VHA, while fulfilling Veterans’ wish to age-in-place.

PI_NAMEs: GATELY, MEGAN ELIZABETH (contact)

PROJECT_TERMS: acceptability and feasibility;Activities of Daily Living;Age;aging in place;Caregivers;Clinic;Communities;cost;Data;Dementia;dementia care;dementia risk;Development;Diagnosis;disability;disability risk;evidence base;experience;Face;Feedback;functional decline;functional independence;functional loss;Future;Health Services Accessibility;Hearing;high risk;human old age (65+);Instruction;instrumental activity of daily living;Intervention;Interview;Life;Medical center;Medication Management;Methods;Mission;Occupational Therapist;pilot test;preservation;prevent;programs;Protocols documentation;Rural;rurality;satisfaction;Services;Structure;Surveys;Target Populations;Technology;telehealth;telerehabilitation;Toothbrushing;Training;Travel;Veterans;video delivery;Visit

PROJECT_TITLE: Feasibility of a Video Telehealth Functional Assessment for Veterans with Dementia

STUDY_SECTION: RRDS

STUDY_SECTION_NAME: Rehabilitation Research and Development SPiRE Program[RRDS]


ORG_CITY: IRVINE

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

ORG_STATE: CA

PHR: PROJECT NARRATIVE Chronic immune activation is a key factor underlying the non-AIDS-related conditions that result in reduced survival in persons living with HIV. We propose to investigate the role of nucleic acid-containing immune complexes in inducing or sustaining immune activation, with the long-term goal of developing strategies to improve survival rates.

PI_NAMEs: FORTHAL, DONALD N (contact)

PROJECT_TERMS: 3-Dimensional;Acceleration;age acceleration;Aging;Antibodies;antibody engineering;Antigen-Antibody Complex;antiretroviral therapy;atherogenesis;Atherosclerosis;Autoimmune Diseases;Binding;Blood Vessels;CD4 Positive T Lymphocytes;Cell Adhesion Molecules;Cell Physiology;Cell surface;Cells;chemokine;Chronic;cytokine;Data;Defective Viruses;design;Disease;early onset;Endothelial Cells;endothelial dysfunction;Epithelium;Experimental Designs;Functional disorder;gastrointestinal epithelium;Gene Expression;General Population;Genetic Transcription;Genome;Goals;Histopathology;HIV;HIV-1;Human;IgG1;immune activation;immune RNA;Immunoglobulin G;Immunologic Markers;improved;In Situ;In Vitro;Individual;Infection;Inflammaging;Inflammation;Inflammatory;Inflammatory Response;intraperitoneal;Kidney Diseases;Life Expectancy;Link;Liver diseases;Lupus;Macaca;Macrophage;Macrophage Activation;Measures;Mediating;microbial;Microfluidics;Modeling;monocyte;Morbidity - disease rate;mortality;Mus;novel therapeutic intervention;Nucleic Acids;Organ;Pathogenesis;Pathogenicity;Patients;Persons;Phagocytes;Pharmaceutical Preparations;Physiological;Plasma;Play;Publishing;receptor;Research;Ribonucleoproteins;RNA;RNA Recognition Motif;Role;SIV;Survival Rate;Testing;three-dimensional modeling;Tissues;TLR7 gene;TLR8 gene;Toll-like receptors;Transgenic Mice;Vascular Permeabilities;Vascularization;Viral;Viral reservoir;Viremia;Virus;Virus Replication

PROJECT_TITLE: Nucleic acid-containing immune complexes and immune activation

STUDY_SECTION: HIVD

STUDY_SECTION_NAME: HIV Immunopathogenesis and Vaccine Development Study Section[HIVD]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: HIV/AIDS;Infectious Diseases

ORG_CITY: ATLANTA

ORG_DEPT: CHEMISTRY

ORG_NAME: GEORGIA INSTITUTE OF TECHNOLOGY

ORG_STATE: GA

PHR: PROJECT NARRATIVE This project seeks to understand how cellular lipid biology can control HIV entry. It uses molecular dynamics simulation coupled closely to experimental validation to design nonreplicating HIV mutants that have altered dependence on cellular lipids. A molecular and functional understanding of how HIV proteins interact with these lipids will help design new interventions that could reduce HIV infection.

PI_NAMEs: KASSON, PETER M (contact)

PROGRAM_OFFICER_NAME: MCDONALD, DAVID JOSEPH

PROJECT_TERMS: Affect;Behavior;beta pleated sheet;Biochemical;Biochemistry;Biological Assay;Biology;Biophysics;Cell fusion;Cell membrane;Cells;Cholesterol;Consequences of HIV;Coupled;Dependence;design;Disease;Fluorescence;Free Energy;Glycoproteins;HIV;HIV Infections;Impairment;Infection;Influenza;Intervention;Link;Lipids;Liquid substance;Mediating;Membrane;Membrane Fusion;membrane model;Microscopy;Molecular;Molecular Conformation;molecular dynamics;mutant;Mutation;Optics;particle;Peptide Conformation;Peptides;Phase;preference;Process;Property;Proteins;Rationalization;receptor;simulation;Structure;Testing;Validation;Viral;Virus;Virus Diseases;Work

PROJECT_TITLE: Conformational Dynamics and Functional Consequences of HIV Fusion at Lipid Phase Boundaries

STUDY_SECTION: HVCD

STUDY_SECTION_NAME: HIV Molecular Virology, Cell Biology, and Drug Development Study Section[HVCD]


ADMINISTERING_IC: GM

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering

ORG_CITY: TALLAHASSEE

ORG_DEPT: MISCELLANEOUS

ORG_NAME: FLORIDA STATE UNIVERSITY

ORG_STATE: FL

PHR: PROJECT NARRATIVE  Nuclear magnetic resonance (NMR) spectroscopy is a powerful technique used to non-invasively identify metabolites and to examine the three-dimensional structure, dynamics, and interactions of proteins. We seek to develop superconducting magnet technology for next-generation NMR systems with 1.3-1.5 GHz 1H capability by a technology demonstration of novel Bi2Sr2CaCu2Ox HTS conductor and coil technologies pioneered at the National High Magnetic Field Laboratory.

PI_NAMEs: TROCIEWITZ, ULF PETER (contact)

PROGRAM_OFFICER_NAME: BARNES, CHARLES ASHLEY

PROJECT_TERMS: Academy;Area;Articulation;Biological;Biomedical Research;Budgets;Characteristics;cold temperature;Collaborations;Compensation;cost;density;design;Development;Diameter;Electronics;Engineering;Equipment;experience;Filament;Funding;Future;Goals;high energy physics;High temperature of physical object;Hybrids;improved;innovation;instrument;Laboratories;Laboratory Scientists;Length;magnetic field;Magnetic Resonance;Mechanics;Minority;new technology;next generation;NMR Spectroscopy;novel;Nuclear Magnetic Resonance;operation;Pathway interactions;Positioning Attribute;pressure;Price;Process;programs;Proteins;Reaction;Research Personnel;Resolution;Resources;screening;Series;Stress;System;Techniques;Technology;Temperature;three dimensional structure;timeline;United States National Institutes of Health;Validation;Width

PROJECT_TITLE: Ultra-High Field NMR Magnets with Multifilament High Temperature Superconductors

STUDY_SECTION: EBIT

STUDY_SECTION_NAME: Enabling Bioanalytical and Imaging Technologies Study Section[EBIT]


ORG_CITY: St. Louis

ORG_NAME: ST. LOUIS VA MEDICAL CENTER

ORG_STATE: MO

PHR: Every year ~3000-3500 veterans are diagnosed with chronic kidney disease (CKD). In many of these affected individuals there is progressive kidney fibrosis leading to end stage organ failure and a need for dialysis and transplantation. Currently, more than 10,000 veterans are receiving dialysis in the VA health care system. Glomerular diseases, such as focal segmental glomerulosclerosis (FSGS) are a frequent cause of kidney failure. In addition, CKD is a major risk factor for cardiovascular morbidity and mortality. Low nephron number due to congenital renal hypo/dysplasia, premature birth and intrauterine growth retardation (IUGR) significantly increase the risk of glomerulosclerosis, CKD and HTN. These conditions disproportionately affect African Americans, a group that is highly represented among veterans. The proposed research is relevant to public health and to the mission of the VA because the information learned from these studies is expected to provide novel mechanistic insights into FSGS that may lead to therapeutic interventions to prevent the disease.

PI_NAMEs: RAUCHMAN, MICHAEL I (contact)

PROJECT_TERMS: Acceleration;Adult;Affect;African American population;Albuminuria;Atrophic;Autoimmune Diseases;Automobile Driving;Binding;Bioinformatics;Biological Process;Birth;candidate identification;cardiovascular risk factor;Cardiovascular system;cell injury;Cells;Cellular Metabolic Process;Chromatin;chromatin immunoprecipitation;Chromatin Remodeling Factor;Chronic;Chronic Kidney Failure;Cicatrix;Clinical;Compensation;Complex;Data;Data Set;Deacetylase;Defect;Development;Diagnosis;Dialysis procedure;Disease;Disease Progression;disorder risk;Drug toxicity;Dysplasia;Early identification;effective therapy;End stage renal failure;end-stage organ failure;Endowment;Enhancers;Environmental Risk Factor;Epigenetic Process;epigenome editing;Epithelium;Event;fatty acid oxidation;Fetal Growth Retardation;Fibrosis;Focal and Segmental Glomerulosclerosis;functional adaptation;Functional disorder;Gene Expression;Gene Expression Regulation;gene regulatory network;Genes;Genetic;Genetic Transcription;genome-wide;Genomic Segment;Genomics;Genus Hippocampus;glomerular filtration;glomerulosclerosis;Goals;Growth;Healthcare Systems;hemodynamics;Heterozygote;Hi-C;High Fat Diet;High Prevalence;Human;human disease;Hypertrophy;Individual;Inherited;injured;Injury;Injury to Kidney;insight;interstitial;Intervention;intrauterine environment;Kidney;Kidney Diseases;Kidney Failure;kidney fibrosis;Lead;Learning;Life;lipid metabolism;Lipids;loss of function;Low Birth Weight Infant;Measures;Mediating;meetings;Metabolic;Metabolic Pathway;Metabolic stress;Metastasis-associated protein;Methods;Mission;Mitochondria;mitochondrial dysfunction;mitochondrial metabolism;Modeling;Molecular;Molecular Conformation;Morbidity - disease rate;Morphology;mortality;mouse model;Multiomic Data;Mus;mutant;Mutant Strains Mice;Mutation;Nephrectomy;nephrogenesis;nephron progenitor;Nephrons;novel;Nucleic Acid Regulatory Sequences;Nucleosomes;Onset of illness;Pathogenesis;Pathogenicity;Pathologic;Pattern;Phenotype;Physiological;Play;podocyte;Population;postnatal;Predisposition;premature;Premature Birth;prevent;Process;Prognosis;programs;promoter;Proteinuria;Public Health;Reactive Oxygen Species;Regulator Genes;Regulatory Element;Renal function;Renal glomerular disease;Research;Research Personnel;Resolution;response;Risk;Risk Factors;Risk Reduction;Role;Severities;Spirometry;stem cells;Stress;stressor;Technology;Testing;Therapeutic Intervention;Tissues;Transplantation;Tubular formation;Veterans

PROJECT_TITLE: Epigenetic mechanisms in a novel model of FSGS

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 NEPH-N (01)]


NIH_SPENDING_CATS: Brain Disorders;HIV/AIDS;Infectious Diseases;Mental Health;Neurosciences;Prevention

ORG_CITY: GALVESTON

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

ORG_STATE: TX

PHR: Narrative: As individuals with HIV live longer due to antiretroviral therapies' success, the prevalence of cognitive and motor deficits in the infected population is increasing. Astrocytes play a key role in maintaining most CNS functions in physiological conditions, but their importance in the pathogenesis of NeuroHIV has not been well characterized and remains controversial. However, our group demonstrated that glial viral reservoirs use gap junctions (GJ) and hemichannels (HC) to spread toxicity into neighboring uninfected cells despite their low numbers and minimal to undetectable viral replication.

PI_NAMEs: EUGENIN, ELISEO A (contact)

PROJECT_TERMS: Anti-Retroviral Agents;antiretroviral therapy;Apoptosis;Apoptotic;Area;Astrocytes;Brain;Calcium;Cell Communication;Cells;Central Nervous System;Characteristics;Chronic;Cognitive deficits;Communication;Connexin 43;Connexins;Cytoplasm;Data;Dementia;Development;Dinoprostone;DNA Integration;Docking;Environment;extracellular;Functional disorder;gap junction channel;Gap Junctions;Glutamates;Goals;HIV;HIV Infections;Human;Immune;Impaired cognition;In Vitro;in vivo;Individual;Inflammation;Inflammatory;Ions;Laboratories;Lipids;Lymphoid;Macrophage;Mediating;Mediator;Microglia;Minor;Mitochondria;Molecular;motor deficit;motor impairment;Myelogenous;Myeloid Cells;Nervous System Physiology;Nervous System Trauma;neuroAIDS;Neurologic Dysfunctions;Neurons;novel;Organelles;Pathogenesis;Peptides;Physiological;Play;Population;Prevalence;prevent;Primary Infection;Prostaglandins;Protein Secretion;Public Health;receptor;Residual state;RNA;Role;Second Messenger Systems;Signal Transduction;Spatial Distribution;success;Synapses;synaptic function;System;Techniques;therapeutic target;Toxic effect;Viral Proteins;Viral reservoir;Virus;Virus Replication

PROJECT_TITLE: Targeting cell-to-cell communication to prevent bystander damage mediated by viral reservoirs


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Immunization;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_CITY: MINNEAPOLIS

ORG_NAME: HENNEPIN HEALTHCARE RESEARCH INSTITUTE

ORG_STATE: MN

PHR: This project will examine how HIV and age influence the immunogenicity of pneumonia vaccines (how well the immune system is stimulated by these vaccines) with the goal of determining whether specialized approaches are needed to vaccinate individuals living with HIV in advancing age who are on anti-retroviral treatment. It will further examine whether chronic inflammation in persons living with HIV is associated with impaired vaccine responses.

PI_NAMEs: FROSCH, ANNE ELIZABETH PARKER (contact)

PROGRAM_OFFICER_NAME: SALIVE, MARCEL

PROJECT_TERMS: Acute;adaptive immune response;Address;Adult;Affect;Affinity;Age;age effect;Aging;aging population;American;Antibodies;antiretroviral therapy;Autoimmune Diseases;B-Lymphocytes;Biological Markers;Cardiovascular system;CD4 Positive T Lymphocytes;Chronic;chronic inflammatory disease;clinical practice;cohort;comorbidity;cytokine;Data;Development;Diabetes Mellitus;Disease;Dose;Elderly;Ethnic Origin;Frequencies;Functional disorder;Goals;Guidelines;Health;HIV;HIV Infections;HIV Seronegativity;Immune;immune activation;Immune response;Immune system;immune system function;Immunity;Immunization;immunogenicity;Impairment;Individual;Infection;Inflammaging;Inflammation;Inflammatory;inflammatory marker;Knowledge;Lead;life span;Measures;Memory;Memory B-Lymphocyte;Metabolic;Metabolic Diseases;monocyte;Morbidity - disease rate;Obesity;Older Population;Outcome;Participant;Persons;Phenotype;Physiological;Play;Pneumococcal conjugate vaccine;Pneumococcal vaccine;Pneumonia;Population;Premature aging syndrome;Race;Recommendation;Recording of previous events;Recovery;Research;Research Personnel;response;Risk;Role;Sampling;Schedule;sex;Streptococcus pneumoniae;Subgroup;systemic inflammatory response;T cell response;T-Lymphocyte;Time;tool;Vaccination;Vaccine Design;vaccine development;vaccine efficacy;vaccine immunogenicity;vaccine response;vaccine trial;vaccine-induced immunity;Vaccinee;Vaccines;Viral

PROJECT_TITLE: Vaccine immunity and inflammation in the aging person living with HIV


ORG_CITY: NEW YORK

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: PROJECT NARRATIVE Antiretroviral therapies have transformed HIV into a manageable chronic condition but are burdensome and do not cure infection, in part because HIV integrates into the human genome as reactivatable proviruses. In some individuals, however, only proviruses integrated into deeply inactive parts of the genome remain – potentially representing a form of cure. This proposal will study and seek to enhance the ability of the cytotoxic (CD8) T-cell arm of the immune system to eliminate all but the most dormant proviruses and thus provide guidance to therapeutic approaches to curing infection.

PI_NAMEs: BUSHMAN, FREDERIC D;JONES, R. BRAD  (contact)

PROGRAM_OFFICER_NAME: SHANKAR, UDAY K

PROJECT_TERMS: Address;Animals;Anti-Retroviral Agents;antiretroviral therapy;arm;Autologous;Binding;Biological Assay;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;cell killing;Cell Survival;Cell Transplantation;Cells;Cessation of life;Characteristics;Chronic;Clinical;Clinical Trials;Clonal Expansion;cytotoxic;Data;Detection;Evaluation;Exhibits;experience;flexibility;Frequencies;gene repression;Genes;Genetic Transcription;Genome;Genomic Segment;Genomics;graft vs host disease;Heterochromatin;HIV;HIV Infections;Human;Human Genome;Immune;immune clearance;immune resistance;Immune system;Immunodeficient Mouse;Immunomodulators;Immunotherapeutic agent;In Vitro;in vivo;Individual;Infection;Insertional Mutagenesis;integration site;Intervention;Intervention Studies;Laboratories;Location;Mediating;memory CD4 T lymphocyte;Modeling;Molecular;mouse model;Mus;Names;novel;Nuclear;Outcome;Participant;Pathway interactions;Pattern;Persons;Pharmaceutical Preparations;Population;pressure;Productivity;Provirus Integration;Proviruses;Research;Resistance;Resolution;Resources;Sampling;Statistical Models;T memory cell;T-Lymphocyte;Testing;Therapeutic;tool;Training;Transplantation;Validation;Viral;Viral Load result;viral rebound;Virus Replication;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Defining and then Maximizing the Footprint of CTL Selection on HIV Integration Site Landscapes to Optimize Cure Strategies


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: HIV/AIDS;Infectious Diseases;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

ORG_DEPT: PATHOLOGY

ORG_NAME: EMORY UNIVERSITY

PHR: PROJECT NARRATIVE Dysfunctional T cells and persistent viral reservoirs are leading causes of failure to HIV/SIV cure. A system to reliably study early T cell generation and their infection is lacking. The proposed work will establish an innovative organoid system in the SIV/NHP model to study T cell generation, infection, and reservoir establishment.

PI_NAMEs: RAHMAN, SHEIKH ABDUL (contact)

PROGRAM_OFFICER_NAME: MIROCHNITCHENKO, OLEG

PROJECT_TERMS: Address;Anti-viral Agents;antiretroviral therapy;Applications Grants;Binding;Biological Assay;biomarker discovery;Blood;Bone Marrow;Bone Marrow Aspiration;CD3 Antigens;CD34 gene;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;Cells;Characteristics;chemokine;Chronic;cytokine;Data;Defect;Development;DNA;Dysplasia;Event;Failure;falls;Frequencies;Functional disorder;Future;Generations;Grant;hematopoietic stem cell differentiation;Hematopoietic stem cells;Heterogeneity;HIV;HIV/AIDS;Homing;Human;Human immunodeficiency virus test;Immune;In Vitro;in vivo;Infection;innovation;Integrins;Investigation;Kinetics;Knowledge;latent infection;Latent virus infection phase;Lymphopenia;Macaca;Mature T-Lymphocyte;Methods;Modeling;NIH Office of AIDS Research;nonhuman primate;novel;Ontology;Organoids;Pathway interactions;Pharmaceutical Preparations;Population;Population Characteristics;Productivity;progenitor;Property;regeneration potential;regenerative cell;Reporting;Reproducibility;Research;Resources;response;Role;Sampling;screening;Serum;Site;SIV;Source;stem cells;System;T-Cell Development;T-Lymphocyte;T-Lymphocyte Subsets;TCR Activation;Testing;thymocyte;Thymus Gland;Tissues;Transcriptional Regulation;transcriptomics;United States National Institutes of Health;Validation;Viral;viral DNA;Viral Load result;Viral reservoir;viral RNA;Virus Diseases;Virus Latency;Work

PROJECT_TITLE: Artificial thymic organoid platform to study T cell development and HIV/SIV infection using SIV/macaque model of HIV/AIDS


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Dissemination and Implementation Research;HIV/AIDS;Heart Disease;Hypertension;Prevention

ORG_CITY: BLOOMINGTON

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: TRUSTEES OF INDIANA UNIVERSITY

ORG_STATE: IN

PHR: PROJECT NARRATIVE Cardiovascular disease is a major health problem among person living with HIV. Despite clinical guidelines recommend HIV clinicians address cardiovascular risk among their patients, this recommendation has not been widely adopted. Using implementation research, community engagement, and computer modeling methods, we will identify strategies to improve adoption of hypertension care guidelines among HIV clinicians.

PI_NAMEs: GALAVIZ, KARLA IVETTE (contact)

PROGRAM_OFFICER_NAME: CAMPO, REBECCA A

PROJECT_TERMS: Address;Adopted;Adoption;Adult;Affect;Area;Awareness;burden of illness;Calibration;Cardiovascular Diseases;cardiovascular disorder prevention;cardiovascular disorder risk;cardiovascular risk factor;care outcomes;career;Caring;Cause of Death;Clinic;Clinical;Communities;community advisory board;community engagement;Computer Models;County;Data;design;Detection;Diagnosis;Disease Outcome;diverse data;Education;Educational workshop;Engineering;Epidemic;Event;experience;Feedback;Goals;Grant;Guideline Adherence;Guidelines;Health;HIV;HIV Infections;HIV Seronegativity;Hybrids;Hypertension;hypertension treatment;implementation research;implementation strategy;improved;Indiana;K-Series Research Career Programs;Leadership;Mentors;Methods;Mission;Modeling;Modification;Morbidity - disease rate;mortality;Motivation;National Heart, Lung, and Blood Institute;Output;Patients;Persons;Population;Prevalence;Preventive;Preventive care;programs;prototype;Public Health;Recommendation;Research;Research Personnel;Research Priority;Resources;response;Retrospective cohort;Risk Factors;Risk Management;Science;service providers;System;systemic inflammatory response;Testing;tool;treatment guidelines;Validation;Work

PROJECT_TITLE: Improving hypertension care for persons with HIV in Indiana: a participatory agent-based model

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-Z (J2)]


ADMINISTERING_IC: DK

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: Newton

ORG_NAME: MELLICELL, INC.

PHR: PROJECT NARRATIVE This project will validate technology with the potential to revolutionize the in vitro stages of drug discovery and development for diabetes and obesity. Beyond general improvement of the conventional in vitro model for adipocytes, the platform will be ideal for uncovering the mechanisms of disease associated genetic signals and will likely be useful for the discovery of candidate weight loss drugs that reduce adipocyte size and improve insulin sensitivity.

PI_NAMEs: BASU, MADHUMITA ;POJOGA, LUMINITA ;POPE, BENJAMIN DANIEL (contact)

PROGRAM_OFFICER_NAME: ARREAZA-RUBIN, GUILLERMO

PROJECT_TERMS: Adipocytes;adipokines;adiponectin;Attention;Bioinformatics;Biological Assay;Biomedical Engineering;Body Weight;Body Weight decreased;Brain;CAV1 gene;Cell Physiology;cell type;Cells;cellular engineering;Cellular Structures;Classification;Clinical Trials;cohort;Collaborations;Complex;cytokine;Data;Desire for food;Diabetes Mellitus;Diagnosis;Disease;drug development;drug discovery;Drug Industry;Drug Targeting;drug testing;Endocrine;Energy Metabolism;Engineering;Epidemic;Exhibits;Fatty acid glycerol esters;Foundations;Functional disorder;GCG gene;Gene Expression;Gene Frequency;Generations;Genetic;genetic linkage analysis;genetic variant;Genotype;Glucose;glucose uptake;Goals;Grant;Hormone secretion;Hormones;Hospitals;Human;Human Pathology;Image;improved;In Vitro;in vitro Model;in vivo;Individual;Inflammatory;innovation;Insulin Resistance;insulin sensitivity;Intervention;invention;Investigation;Leptin;Link;Lipids;Lipolysis;Mediator;Messenger RNA;Metabolic;Metabolic Diseases;Metabolic dysfunction;Methodology;Methods;Minor;Modeling;Morphology;multiple omics;New Agents;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;obesity biomarkers;Organ;Outcome;Pathogenesis;Patients;Peripheral;Pharmaceutical Preparations;Phase;phase 1 study;Phenotype;Prevalence;Proteins;Recreation;Research;Research Personnel;response;risk variant;Scheme;Signal Transduction;Single Nucleotide Polymorphism;Source;Stimulus;success;targeted treatment;Technology;technology validation;Testing;Therapeutic;therapeutic development;Thinness;Tissue Model;Tissues;tool;transcriptome sequencing;two-dimensional;Validation;Variant;Weight-Loss Drugs;Woman

PROJECT_TITLE: Novel Adipocyte Engineering Technology for Modeling Adipocyte Dysfunction in Human Obesity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 EMS-S (10)]


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Biodefense and Related Countermeasures;Biomedical Imaging;Clinical Research;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Lung;Rare Diseases;Tuberculosis

ORG_CITY: BOSTON

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: SUMMARY Tuberculosis is associated with lung injury that can persist despite treatment. This study will characterize the burden, severity, and clinical presentation of post-tuberculosis lung disease, and its association with interleukin- 6 signaling pathways, in tuberculosis patients with and without HIV.

PI_NAMEs: CHRISTOPHER, DEVASAHAYAM JESUDAS;GUPTE, AKSHAY NITIN (contact)

PROGRAM_OFFICER_NAME: HUEBNER, ROBIN E

PROJECT_TERMS: Acute;Acute Lung Injury;Adult;Affect;Age;airway obstruction;Alveolar;Anti-Bacterial Agents;Anti-Inflammatory Agents;antiretroviral therapy;biobank;Biological;Biological Assay;Blood;Cells;Cessation of life;Clinical;Clinical Trials Design;co-infection;cohort;Data;Defect;Dimensions;disability;Disease;drug-sensitive;Emission-Computed Tomography;Endothelium;Enrollment;Epithelium;Fibrinogen;Flow Cytometry;follow-up;Functional disorder;functional status;Funding;Gene Expression;Gene Expression Profile;Genetic Predisposition to Disease;Goals;Government;health related quality of life;Health Status;High Resolution Computed Tomography;HIV;HIV Seronegativity;HIV Seropositivity;HIV/TB;IL17 gene;IL6 gene;IL6ST gene;imaging approach;Immune;Immunologic Tests;Immunologics;immunopathology;Immunosuppression;Impairment;improved;India;Inflammatory;inflammatory marker;Inflammatory Response;Interleukin-1 beta;Interleukin-6;Intervention;Knowledge;Link;Lung;Lung Diseases;lung imaging;lung injury;Matrix Metalloproteinases;Measures;mortality;novel;Outcome;Pathologic;Pathway interactions;Patients;Phenotype;Phosphorylation;Physiological;Play;Polymerase Chain Reaction;Positron-Emission Tomography;prevent;Property;prospective;Protocols documentation;pulmonary function;Pulmonary function tests;Pulmonary Inflammation;Pulmonary Pathology;Pulmonary Tuberculosis;Pulse Oximetry;Questionnaires;Recovery of Function;Reporting;Research;Resolution;respiratory health;Role;Sampling;Severities;Severity of illness;sex;Signal Pathway;Signal Transduction;Single Nucleotide Polymorphism;Site;smoking exposure;Smooth Muscle Myocytes;Sputum;Standardization;Survivors;Testing;therapeutic target;TNF gene;TNF-alpha converting enzyme;Total Lung Capacity;Transforming Growth Factor beta;Tuberculosis;tuberculosis treatment;United States National Institutes of Health;Vascular Endothelial Growth Factors;Walking;Whole Blood;X-Ray Computed Tomography

PROJECT_TITLE: Interleukin-6 signaling, lung injury, and post-TB lung disease in TB-HIV

STUDY_SECTION: HCAC

STUDY_SECTION_NAME: HIV Coinfections and HIV Associated Cancers Study Section[HCAC]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Biotechnology;Brain Disorders;Congenital Structural Anomalies;HIV/AIDS;Nanotechnology;Neurosciences;Pediatric;Pediatric - AIDS;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Women's Health Research

ORG_CITY: OMAHA

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

PHR: Project Narrative Proposal seeks to evaluate DTG-linked impaired neurodevelopmental outcomes with underlying mechanisms, assess long-acting poloxamer-encapsulated DTG nanoformulations as potential delivery means to improve safety and therapeutic profile of DTG during pregnancy and establish scientific exchange with ongoing clinical study examining children exposed to DTG in utero in Botswana for validating findings through clinical relevance.

PI_NAMEs: BADE, ADITYA N (contact)

PROGRAM_OFFICER_NAME: MOYE, JACK

PROJECT_TERMS: Adolescence;Adverse effects;Adverse event;Age;Anti-Retroviral Agents;Apoptosis;arm;Attenuated;Basic Science;Behavioral;behavioral outcome;Binding;Biological Assay;Blood;Botswana;Brain;brain health;Brain imaging;Brain region;brain tissue;Catalytic Domain;Cell Proliferation;Child;child bearing;Childhood;Clinical;Clinical Data;Clinical Research;clinically relevant;Combined Modality Therapy;Conceptions;Country;critical period;Data;design;Development;developmental neurotoxicity;Diffusion Magnetic Resonance Imaging;Dose;Drug Delivery Systems;Drug Exposure;Drug Kinetics;Drug usage;Electrophysiology (science);Embryo;embryo tissue;Encapsulated;Evaluation;Exposure to;Female;Female of child bearing age;fetal;Funding;Genetic;Grant;HIV-1;Impairment;improved;in utero;infancy;Infection;Inhibition of Matrix Metalloproteinases Pathway;Injectable;Integrase Inhibitors;interest;Knowledge;Learning;Link;Magnetic Resonance Imaging;Magnetic Resonance Spectroscopy;malformation;Mass Spectrum Analysis;Matrix Metalloproteinase Inhibitor;Matrix Metalloproteinases;Measurement;Measures;Memory;Memory impairment;Metabolic;Molecular;Monitor;Mothers;mouse development;Mus;nanoformulation;neurobehavioral;neurobehavioral test;neurodevelopment;Neurodevelopmental Deficit;Neurodevelopmental Impairment;neuroinflammation;Neurologic;neuron development;Neurons;neuropathology;neuroprotection;neuropsychiatry;neurotoxicity;NNRTI-resistance;North America;novel;novel therapeutics;Oral Administration;Outcome;Pathology;Pathway interactions;Peripheral;Persons;Pharmaceutical Preparations;Physiological;Placenta;Plasma;Poloxamers;Polymerase Chain Reaction;Population;postnatal;postnatal development;preclinical study;Pregnancy;pregnant;Pregnant Women;prenatal;prevent;Prevention therapy;Property;Protons;pup;Radial;Recommendation;Recurrence;Regimen;Reporting;Research;Resistance;Resolution;Resources;response;Risk;Rodent Model;Safety;Scheme;Science;Spinal Cord;Structural defect;Structure;surfactant;System;Testing;theories;Therapeutic;Therapeutic Intervention;therapy resistant;Tissues;Toxic effect;transcriptomics;translational approach;translational impact;treatment guidelines;United States National Institutes of Health;Validation;Vibrissae;Weight Gain;Western Blotting

PROJECT_TITLE: Integrase Inhibitors during pregnancy and Neurodevelopmental Outcomes: Underlying Mechanism and Therapeutic Intervention


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Pediatric;Pediatric - AIDS;Prevention;Racial and Ethnic Minority Health Research;Women's Health Research

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: NARRATIVE There are now two forms of HIV pre-exposure prophylaxis (PrEP) available (oral PrEP and long-acting injectable cabotegravir; CAB-LA), requiring TW patients and PrEP service providers (e.g., navigators, nurses, physicians) to work together to choose between these products. The intentional and informed use of digital tools can enhance clinical communication and shared decision-making; yet few digital shared decision-making tools (SDMT) tailored to TW exist, and none are PrEP-focused. The proposed study builds on formative work by further developing and pilot testing our existing prototype of a PrEP-focused bilingual (English/Spanish) digital SDMT called, “WePrEP,” that is tailored to diverse TW and PrEP service providers and supports shared decision- making regarding selecting an appropriate PrEP method and reviewing corresponding adherence strategies.

PI_NAMEs: RAEL, CHRISTINE TAGLIAFERRI (contact);STONBRAKER, SAMANTHA

PROGRAM_OFFICER_NAME: STIRRATT, MICHAEL JAMES

PROJECT_TERMS: 2 arm randomized control trial;acceptability and feasibility;Address;Adherence;Adoption;AIDS prevention;arm;behavioral health;bilingualism;Black race;Caring;Clinical;Communication;Communities;comparison control;Complex;Comprehension;Data;Decision Making;design;digital;digital tool;efficacy testing;Electronics;ethnic diversity;evidence base;experience;FDA approved;flexibility;Funding;Future;gender affirming hormones;Health;health communication;health literacy;Health Services;Healthcare;high risk population;HIV;HIV Infections;improved;Incidence;Injectable;Injections;Intervention;Interview;Intramuscular Injections;Latina;Link;Literature;Measures;Methods;Minority Groups;Modality;Modeling;Monitor;Nurses;Oral;Outcome Measure;Patients;Perception;Persons;Pharmaceutical Preparations;Physicians;pilot test;Population;Populations at Risk;pre-exposure prophylaxis;preference;Prevalence;prevent;primary outcome;Process;prototype;Provider;Qualitative Methods;racial diversity;racial population;Randomized;Randomized, Controlled Trials;Recommendation;Reporting;Research;secondary outcome;service providers;shared decision making;simulation;Site;social;Spanish/English;standard of care;systemic barrier;Testing;tool;transgender;transgender women;transmission process;treatment arm;United States;uptake;usability;virtual;Visual;women patients;Work

PROJECT_TITLE: WePrEP: A bilingual shared decision-making tool to facilitate conversations between transgender women and their providers as they select an ideal PrEP method


ADMINISTERING_IC: NR

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Prevention;Primary Health Care;Social Determinants of Health;Women's Health Research

ORG_CITY: WASHINGTON

ORG_NAME: GEORGE WASHINGTON UNIVERSITY

ORG_STATE: DC

PHR: Narrative This study explores strategies to promote linkages to HIV care following an HIV self-test (HIVST) for Tanzanian heterosexual men who are shown to test less frequently than women and are less likely seek follow-up care following a self-test. Similar studies have shown that community-based care, including the provision of PrEP and ART, can help mitigate the various barriers that heterosexual men in Sub-Saharan Africa face when seeking HIV care in a traditional facility-based setting. Exploring novel service-delivery settings for HIV care in Tanzania is critically important in the fight against HIV/AIDS in Sub-Saharan Africa, where there are an estimated 28.5 million people living with the disease.

PI_NAMEs: CONSERVE, DONALDSON  (contact)

PROGRAM_OFFICER_NAME: HUSS, KAREN

PROJECT_TERMS: Address;Adherence;Adoption;Affect;Africa South of the Sahara;antiretroviral therapy;arm;Baseline Surveys;care systems;Caring;Client;Clinic;Clinical;Communities;community based care;community clinical linkage;Community Health;comparison control;comparison group;Consolidated Framework for Implementation Research;Control Groups;cost;Country;Diagnostic Reagent Kits;Discrimination;Disease;Education;Effectiveness;effectiveness evaluation;Effectiveness of Interventions;effectiveness testing;effectiveness/implementation study;Equity;Evaluation;experience;Face;Feedback;female sex worker;fighting;follow-up;Funding;group intervention;Health;Health care facility;Health Care Visit;health equity;Health Promotion;Heterosexuals;high risk;HIV;HIV/AIDS;Home;Hour;Hybrids;implementation barriers;implementation facilitators;improved;Intervention;intervention participants;intervention refinement;Link;Malawi;male;Measures;men;men who have sex with men;Modeling;novel;Nurses;Outcome;Participant;peer;Persons;Phase;Pilot Projects;population health;pre-exposure prophylaxis;prevent;Prevention;primary outcome;Privacy;programs;Publishing;Randomized;randomized, clinical trials;Randomized, Controlled Trials;Reporting;Research;Research Design;secondary outcome;self testing;service delivery;service providers;Services;Sexual Partners;Site;social stigma;standard of care;Strategic Planning;systematic review;Tanzania;Test Result;Testing;Therapeutic Intervention;Training;transmission process;Transportation;Travel;treatment arm;two-arm study;United States National Institutes of Health;Viral;Viral Load result;Visit;Woman;World Health Organization

PROJECT_TITLE: Implementation of an HIV Status-Neutral Nurse-Led Intervention to Increase Equity in Clinical Outcomes for Male HIV Self-Testers in Tanzania

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 SCIL-A (03)]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Brain Disorders;Drug Abuse (NIDA only);Genetics;HIV/AIDS;Infectious Diseases;Methamphetamine;Neurodegenerative;Neurosciences;Stimulant Use and Misuse;Substance Misuse

PHR: Project Narrative: This R01 application aims to determine how exposure to HIV Tat and methamphetamine induce the astrocyte- specific inflammasome, NLRP6, and its role in PANoptosis-mediated neuroinflammation in NeuroHIV. Using in vitro, ex vivo, and in vivo approaches, this proposal will identify the novel molecular mechanism(s) involved in HIV Tat and methamphetamine in the context of activation of ZBP1/NLRP6-mediated PANoptosis and neuroinflammation. The goal is to identify novel therapeutic targets to alleviate neuroinflammation associated with NeuroHIV, and the outcome of this study will set the stage for developing novel therapeutics.

PI_NAMEs: PERIYASAMY, PALSAMY  (contact);SIL, SUSMITA

PROGRAM_OFFICER_NAME: POLLOCK, JONATHAN D

PROJECT_TERMS: Adherence;antiretroviral therapy;Apoptosis;Astrocytes;Behavioral Assay;bisulfite;Brain;brain tissue;CASP1 gene;CASP6 gene;CASP8 gene;Cells;Centers for Disease Control and Prevention (U.S.);Central Nervous System;Complex;Confocal Microscopy;cytokine;cytotoxic;Data;demethylation;DNA;DNA Methylation;DNA sequencing;Doxycycline;Drug abuse;Enzyme-Linked Immunosorbent Assay;Enzymes;Epidemic;epigenetic regulation;Exposure to;Family;Gene Silencing;Genetic Transcription;Genomic DNA;glial activation;Goals;HIV;HIV Infections;HIV-1;HIV-associated neurocognitive disorder;IL18 gene;Immunofluorescence Immunologic;In Vitro;in vivo;Individual;Inflammasome;Inflammatory;Interleukin-1 beta;Knowledge;Macaca;marenostrin;Mediating;Mediator;Methamphetamine;methamphetamine exposure;Microglia;Molecular;Mus;neuroAIDS;neuroinflammation;new therapeutic target;novel;novel therapeutics;Outcome Study;Pathway interactions;Persons;pharmacologic;promoter;Proteins;response;RIPK1 gene;RIPK3 gene;Role;Signal Transduction;Stimulant;tat Protein;Testing;Transgenic Organisms;Viral Proteins;Viremia;Western Blotting;Z-DNA Binding Protein

PROJECT_TITLE: Epigenetic regulation of astrocyte-specific NLRP6 inflammasome and PANoptosis in HIV Tat and methamphetamine-mediated neuroinflammation


NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Mental Health;Mental Illness;Post-Traumatic Stress Disorder (PTSD);Telehealth

ORG_CITY: NEW HAVEN

ORG_NAME: OUI THERAPEUTICS, INC

PHR: PROJECT NARRATIVE Post-traumatic stress disorder (PTSD) is a chronic, debilitating health problem that affects 4.7% of adults in the US and has a total economic cost of $232.2 billion, annually. Despite the existence of effective treatments, many patients do not receive treatment due to barriers such as time, cost, or limited access to qualified therapists. To reduce these barriers, we will develop and test a digital therapeutic (i.e., a mobile app that delivers a health intervention) that utilizes empirically-supported cognitive-behavioral techniques to treat adults with PTSD.

PI_NAMEs: FEUERSTEIN, SETH ;SIMON, PATRICIA  (contact)

PROGRAM_OFFICER_NAME: SWEENEY, MARY MARGARET

PROJECT_TERMS: acceptability and feasibility;Adult;Affect;anxiety sensitivity;Arousal;Behavioral;behavioral health intervention;Caring;chatbot;Chronic;clinically significant;Cognition;Cognitive;Cognitive Therapy;commercialization;comorbidity;comparative efficacy;cost;Data;Development;digital health;digital solutions;digital treatment;dosage;Dose;Double-Blind Method;Dropout;Drug Industry;DSM-V;economic cost;effective therapy;Effectiveness;effectiveness evaluation;Enrollment;Evaluation;Event;Evidence based treatment;Exercise;experience;Exposure to;Futility;Health;health plan;Healthcare;improved;Individual;industry partner;Infrastructure;Intervention;Knowledge;Letters;Marketing;Measures;Mediation;Memory;Meta-Analysis;mobile application;Modeling;Modification;Moods;mortality;novel;novel therapeutics;Participant;Patient Recruitments;Patients;pharmacy benefit;Phase;post intervention;Post-Traumatic Stress Disorders;Prevalence;Protocols documentation;Provider;Publishing;Qualifying;Questionnaires;Randomized;Randomized, Controlled Trials;Recurrence;reduce symptoms;retention rate;smartphone application;social stigma;Software Design;Software Engineering;Substance Use Disorder;suicidal;Symptoms;System;Techniques;Testing;Therapeutic;Time;Training;Trauma;traumatic event;treatment as usual;treatment effect;treatment strategy;Unemployment;uptake;usability

PROJECT_TITLE: Development and Evaluation of a Novel Digital Therapeutic for Adults with Post-Traumatic Stress Disorder

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BP-C (10)]


ORG_CITY: WORCESTER

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: PROJECT NARRATIVE Our results show that the cellular protease ADAM10 is taken up into HIV-1 particles, cleaves viral proteins required to enter a new target cell, and inhibits the propagation of HIV-1. Our application proposes an in-depth investigation of the mechanism by which ADAM10 impairs the spreading of HIV-1, and of how HIV-1 has adapted to minimize its inhibition by ADAM10. The proposed studies are relevant to public health, because they have the potential to identify a novel vulnerability that can be exploited to inactivate HIV-1.

PI_NAMEs: GOTTLINGER, HEINRICH  (contact)

PROJECT_TERMS: Affect;Agonist;alpha helix;Antibodies;Binding;C-terminal;CD4 Positive T Lymphocytes;Cell membrane;Cell Physiology;Cells;Cellular Membrane;Clathrin Adaptors;Complex;Data;Defect;Disintegrins;Endopeptidases;env Glycoproteins;Epitopes;Excision;Family;Family member;HIV;HIV-1;Human;Impairment;Individual;insight;Integral Membrane Protein;Integration Host Factors;Investigation;Knock-out;Lipids;Mediating;member;Membrane;Membrane Proteins;Metalloproteases;Mutate;Mutation;nef Protein;novel;particle;Peptide Hydrolases;Phosphatidylserines;phospholipid scramblase;Point Mutation;preference;prevent;Public Health;Resistance;Role;Site;Substrate Specificity;T-Lymphocyte;Testing;TFAP2A gene;transmission process;uptake;Viral;Viral Proteins;Virion;Virus

PROJECT_TITLE: Ectodomain shedding and HIV replication


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;HIV/AIDS;Infectious Diseases;Prevention

ORG_CITY: MILWAUKEE

ORG_DEPT: PSYCHIATRY

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: PROJECT NARRATIVE Implementation research is needed to support further roll-out of pre-exposure prophylaxis (PrEP) as an umbrella HIV prevention strategy, yet long-acting injectable PrEP (LAI-PrEP) via intramuscular cabotegravir has unique implications for clinical practice that will not easily fit within implementation strategies for oral PrEP. In this study, we aim to identify determinants to LAI-PrEP roll-out, conduct consensus building with stakeholders to plan optimal strategies to support LAI-PrEP implementation, and pilot a cyclical Plan-Do-Study- Act implementation strategy within two outpatient clinics serving priority populations for HIV prevention. This proposal compliments current research supporting implementation of oral PrEP and will set the stage for larger scale implementation efforts to enhance prescription of LAI-PrEP.

PI_NAMEs: JOHN, STEVEN A (contact)

PROJECT_TERMS: Address;Administrator;Affect;AIDS prevention;Ambulatory Care Facilities;antiretroviral therapy;Authorization documentation;Black race;care delivery;cis-male;Clinic;Clinic Visits;Clinical;clinical practice;Collaborations;Communities;community advisory board;community based participatory research;Computerized Medical Record;Consensus;Consolidated Framework for Implementation Research;consumer demand;cost;Cryopreservation;disparity reduction;Dose;early experience;epidemic preparedness;Evaluation;evidence base;flexibility;Goals;Health;HIV;Hospitals;housing instability;implementation barriers;implementation efforts;implementation evaluation;implementation facilitators;implementation research;implementation strategy;Incidence;Individual;Injectable;Injections;innovation;Insurance;Interview;Intramuscular;Intramuscular Injections;Lesbian Gay Bisexual Transgender Queer;meetings;member;Mental disorders;Methods;multidisciplinary;Muscle;Nurse Practitioners;Nurses;Oral;Patients;Pharmaceutical Preparations;Pharmacists;Physician Assistants;Physicians;pill;Population;Positioning Attribute;pre-exposure prophylaxis;preference;Prevention;Prevention strategy;Process;Provider;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;Research;Research Personnel;Research Support;Resources;response;Sampling;Structure;Substance Use Disorder;Surveys;Testing;tool;transgender women who have sex with men;United States Food and Drug Administration;Viral;Wisconsin;Work

PROJECT_TITLE: Optimizing implementation of long-acting injectable PrEP

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Biomedical Imaging;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Neurosciences;Psychosis;Schizophrenia;Serious Mental Illness

ORG_CITY: STONY BROOK

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

PHR: PROJECT NARRATIVE  This translational and multimodal imaging study uses magnetic resonance (MR) scans to obtain measures of GABA and glutamate in the hippocampus, as well as neuromelanin in the midbrain as an index of dopamine, to examine the inter-relatedness of these transmitter systems in medication-free patients with schizophrenia, compared to controls. This will represent a test in humans of the prominent view in the field derived from clinical and preclinical evidence, proposing that a deficit in GABA function in the hippocampus may lead to hippocampal glutamate excess, which in turn may dysregulate dopamine. If confirmed, this will provide a validated and integrated model of circuit dysfunction that can lead to new therapeutic targets.

PI_NAMEs: WEINSTEIN, JODI JAY (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: Age;Anatomy;Animal Model;Anterior;Antipsychotic Agents;Attention;Autopsy;Back;Biological;Brain;brain based;cerebral blood volume;Cerebrovascular Circulation;Clinical;clinical high risk for psychosis;comparison control;contrast enhanced;Corpus striatum structure;Data;Development;Disease;Disinhibition;Dopamine;dopamine system;dopaminergic neuron;drug development;Ensure;Environment;Equilibrium;Ethnic Origin;Fostering;Functional disorder;Funding;gamma-Aminobutyric Acid;Glutamates;Glutamine;Goals;Hippocampus;Human;Hyperactivity;imaging modality;imaging study;Imaging Techniques;in vivo;in vivo imaging;indexing;Individual;individual patient;innovation;Interneuron function;Interneurons;Lead;life span;Link;Literature;magnetic field;Magnetic Resonance;Magnetic Resonance Imaging;Magnetic Resonance Spectroscopy;Measures;Medical;Methodology;Methods;Methylazoxymethanol Acetate;Midbrain structure;Modeling;Molecular;Multimodal Imaging;multimodality;neural;neural circuit;Neurobiology;neurochemistry;neuroimaging;neuromelanin;Neurons;Neuropsychology;Neurosciences;Neurotransmitters;new therapeutic target;novel;Output;Participant;Parvalbumins;Pathology;Patients;Pharmaceutical Preparations;Physicians;Physiologic pulse;Positron-Emission Tomography;pre-clinical;prenatal;Prevention;Protocols documentation;Proxy;Psychotic Disorders;recruit;Research;Research Personnel;Resources;responsible research conduct;Rodent;Rodent Model;Scanning;Schizophrenia;Scientist;Severities;sex;Signal Transduction;Socioeconomic Status;Substantia nigra structure;Symptoms;System;Testing;therapeutic evaluation;Tobacco use;Training;Training Programs;United States National Institutes of Health;Ventral Striatum

PROJECT_TITLE: Towards an Integrated Understanding of Neurotransmitter Dysfunction in Schizophrenia: a Multimodal MRI Study


NIH_SPENDING_CATS: Genetics;HIV/AIDS;Infectious Diseases

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: TUFTS UNIVERSITY BOSTON

PHR: Narra$ve In prior studies of human endogenous retroviruses (HERVs), we encountered one that has evolved into a restric=on factor whose expression blocks replica=on of both the same HERV and some other retroviruses including HIV. The goal of the project proposed here is to obtain a detailed understanding of the mechanism of restric=on of both viruses by this provirus; to elucidate its evolu=onary history; and to test whether it can be ac=vated in target cells to protect the host against the consequences of HIV infec=on.

PI_NAMEs: COFFIN, JOHN M (contact)

PROGRAM_OFFICER_NAME: NOVAK, LEIA KAYE

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Affinity;AIDS prevention;Amino Acids;Binding;Biological Assay;Biology;C-terminal;Capsid;CD4 Positive T Lymphocytes;Cell membrane;Cells;Chromosome 3;Clustered Regularly Interspaced Short Palindromic Repeats;Coculture Techniques;Collaborations;Confocal Microscopy;Consensus;Consequences of HIV;CRISPR/Cas technology;Cryoelectron Microscopy;Development;DNA;DNA Sequence Databases;Dominant-Negative Mutation;Electrons;Endogenous Retroviruses;Ensure;Escape Mutant;Evolution;Extinction;Failure;feasibility testing;flexibility;follow-up;Fossils;Funding;gag Gene Products;Genomic DNA;Germ Cells;Goals;Gorilla gorilla;HIV;HIV drug resistance;HIV Infections;HIV-1;Human;Human body;human data;human tissue;Hybrids;in vivo;Individual;Infection;insight;Lentivirus;Longitudinal Studies;Malignant Neoplasms;Methods;Microscopic;mutant;Mutate;Mutation;novel;particle;permissiveness;Phenotype;Production;programs;Property;Proteins;Proviruses;Recording of previous events;Research;Resistance;resistance mutation;Retroviridae;Role;Site;Site-Directed Mutagenesis;Solid;Structure;System;Testing;Tissues;Titrations;Universities;Variant;Virion;virology;Virus;Virus Replication;Whole Blood;Work

PROJECT_TITLE: Human endogenous provirus inhibition of HIV replication


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;HIV/AIDS;Infectious Diseases;Prevention;Social Determinants of Health;Substance Misuse;Women's Health Research

ORG_CITY: SAN DIEGO

ORG_NAME: SAN DIEGO STATE UNIVERSITY

PHR: PROJECT NARRATIVE Hazardous alcohol use is prevalent among men living with HIV (MLWH) in Uganda and associated with non- adherence to antiretroviral therapy (ART) and detectable viral load, which is especially problematic in serodiscordant partnerships with pregnant partners as it threatens Uganda’s progress towards HIV elimination goals. Therefore, intervening on hazardous alcohol use among MLWH with serodiscordant pregnant partners is critical to both HIV prevention and treatment efforts. We apply the Exploration, Preparation, Implementation, Sustainment (EPIS) framework to guide adaptation of an intervention with strong preliminary efficacy reducing alcohol use and improving ART adherence among MLWH in Uganda for use specifically among MLWH with serodiscordant pregnant partners.

PI_NAMEs: MILLER, AMANDA PEARL (contact)

PROGRAM_OFFICER_NAME: FREEMAN, ROBERT

PROJECT_TERMS: Acute;Address;Adherence;Administrator;Africa South of the Sahara;AIDS prevention;Alcohol abuse;Alcohol consumption;Alcohols;antiretroviral therapy;Applied Research;Area;Award;Behavior;Behavioral;behavioral economics;Biofeedback;Biological Markers;Biosensor;care outcomes;Cellular Phone;Child;Clinic;Communication;Communities;community academic partnership;comorbidity;Counseling;Couples;design;Economics;effectiveness-implementation RCT;effectiveness/implementation hybrid;Ensure;Evaluation;Evidence based intervention;experience;Exploration, Preparation, Implementation, and Sustainment;Family;Feedback;Female;Fishes;Focus Groups;Funding;global health;Goals;Government;hazardous drinking;high risk;HIV;HIV risk;implementation evaluation;implementation intervention;implementation outcomes;implementation research;implementation science;improved;Individual;Infection;Infrastructure;Intervention;Intervention Studies;intimate partner violence;Lead;lens;male;Measures;medication nonadherence;men;Mentored Research Scientist Development Award;Mentors;Mentorship;Methodology;Methods;Mind;Modality;Modification;motivational enhancement therapy;Participant;Phase;phosphatidylethanol;pilot test;Population;Postpartum Period;Pregnancy;pregnant;Pregnant Women;Preparation;primary outcome;Process;Provider;psychosocial;Public Health;Randomized, Controlled Trials;reduced alcohol use;Research;Research Methodology;Research Personnel;Resources;response;Risk;Risk Reduction;Safety;Savings;scale up;Site;skills;success;syndemic;Target Populations;Techniques;Testing;Text Messaging;therapy adherence;Training;transmission process;Uganda;Vertical Transmission;Viral;Viral Load result;Work

PROJECT_TITLE: Utilizing Implementation Research Methodologies to Adapt an Intervention to Reduce Alcohol Use and Improve HIV Care Outcomes among Men Living with HIV who have Serodiscordant Pregnant Partners


NIH_SPENDING_CATS: Adolescent Sexual Activity;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Mental Health;Pediatric;Pediatric - AIDS;Prevention;Primary Health Care

ORG_NAME: YALE UNIVERSITY

PHR: PROJECT NARRATIVE In the United States, age-based inequities in access to confidential HIV testing are a major barrier to reducing the incidence of improve the implementation of clinical guidelines on confidential care as standard practice in pediatric primary care settings, thereby increasing HIV testing uptake among adolescents. The research and training in this application will prepare the candidate for an independent scientific career addressing health inequities among adolescents through structural interventions with high capacity for real-world implementation and dissemination. of HIV and associated negative health outcomes among adolescents. Informed by the perspectives pediatric primary care patients, providers, and clinic leadership, this research will

PI_NAMEs: AIVADYAN, CHRISTINA MARIA (contact)

PROGRAM_OFFICER_NAME: KAMATH, SUSANNAH M A

PROJECT_TERMS: acceptability and feasibility;access disparities;Active Learning;Address;Adolescent;Adolescent Health Services;adolescent patient;Age;age group;aged;AIDS prevention;Awareness;career;Caring;Child;Childhood;Clinic;Clinical;clinical implementation;community based participatory research;Connecticut;Consent;Data Collection;Development;Diagnosis;Dissemination and Implementation;Educational workshop;Effectiveness of Interventions;Electronic Health Record;Environment;Epidemic;Equity;evidence base;Focus Groups;Future;Goals;Guidelines;Health;health care settings;health equity promotion;health inequalities;Health Personnel;Health Services;High School Student;HIV;HIV Infections;HIV-infected adolescents;Human immunodeficiency virus test;implementation outcomes;implementation science;Improve Access;improved;Incidence;Inequity;Intervention;intervention delivery;Laws;Leadership;Link;Medical;Mentored Research Scientist Development Award;Mentorship;Minor;multi-component intervention;multidisciplinary;multiphase optimization strategy;National Institute of Mental Health;New Jersey;novel;Outcome;Participant;Patient Preferences;patient screening;Patients;Persons;Phase;pilot test;Positioning Attribute;practice setting;pre-exposure prophylaxis;Preparation;Prevention;prevention service;Primary Care;primary care clinic;primary care patient;primary care setting;Privacy;Protocols documentation;Provider;Public Health;Recommendation;recruit;Reporting;Research;Research Personnel;responsible research conduct;Risk;Services;Sexual Health;Strategic Planning;Surveys;System;Testing;testing uptake;therapy development;Time;Training;transmission process;treatment services;United States;Universities;Unsafe Sex;uptake;Viral;Visit;Youth

PROJECT_TITLE: Implementation of Confidential Care to Increase Adolescent HIV Testing in Pediatric Primary Care Settings


NIH_SPENDING_CATS: Genetics;Infectious Diseases

ORG_CITY: AMHERST

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

PHR: Project Narrative: AIDS-associated cryptococcosis continues to ravage communities impacted by high HIV transmission rates, causing 15% of AIDS-associated mortality. Our work investigates the molecular mechanisms by which C. neoformans, among the millions of species of fungi, is able to adapt to the host environment, coping with the stresses it encounters. We have identified pathways required for agility in stress adaptation, and will investigate how they promote stress adaptation, cooperate with other pathways, and how conserved these responses are across diverse clinical isolates from people with AIDS-associated cryptococcosis as well as environmental isolates from the same region.

PI_NAMEs: PANEPINTO, JOHN C (contact)

PROGRAM_OFFICER_NAME: LOVE, DONA

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Adult;Affect;Africa;Amino Acids;Antifungal Therapy;Area;Biogenesis;biological adaptation to stress;Cellular Stress;Clinical;Collection;Communities;Cryptococcosis;Cryptococcus neoformans;Cytoplasm;Data;Defect;Disadvantaged;Environment;Excision;Exhibits;fungus;Future;Genes;Genome;Geography;global health;Growth;Heterogeneity;high throughput screening;HIV;HIV/AIDS;Investigation;lonely individuals;Masks;Mediating;Meningoencephalitis;Messenger RNA;Mitochondria;Molecular;Molecular Profiling;mortality;mouse model;mRNA Decay;mutant;Mutation;Nonsense-Mediated Decay;Outcome;Output;Oxidative Stress;p38 Mitogen Activated Protein Kinase;pathogen;Pathogenesis;pathogenic fungus;Pathogenicity;Pathway interactions;Persons;Phenotype;Phosphorylation;Phosphotransferases;polysome profiling;posttranscriptional;Process;Production;Property;Quality Control;Reactive Oxygen Species;Regulation;Regulatory Pathway;Regulon;Resistance;Resources;response;Ribosomes;Role;Starvation;Stress;Stress and Coping;stress tolerance;Temperature;Testing;Therapeutic Intervention;transcription factor;Transcriptional Activation;Translating;translation assay;Translation Initiation;Translational Regulation;Translations;translatome;transmission process;Virulence;Work;Yeast Model System

PROJECT_TITLE: Stress Responsive Reprogramming of Translating mRNA Pools in C. neoformans


ADMINISTERING_IC: LM

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Prevention;Primary Health Care;Social Determinants of Health;Violence Against Women;Violence Research;Women's Health Research

ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: PROJECT NARRATIVE Our proposed project includes several short courses designed to complement and enhance the training of a new generation of the public health workforce in diverse career stages to gain strong understanding and skills in methods to advance the intersection of HIV prevention and gender and health justice. Focused on undergraduate students, MPH students, and community health workers, our project will build on the intellectual capital and infrastructure of the world-class University of California Center for Gender and Health Justice. Page 1 of 1

PI_NAMEs: ARAYASIRIKUL, SEAN  (contact);SMITH, MELISSA COOLIDGE;SWENDEMAN, DALLAS TRAVIS;UPADHYAY, USHMA DESAI;WAGMAN, JENNIFER ANN

PROGRAM_OFFICER_NAME: BARR, ELIZABETH ANNE

PROJECT_TERMS: abortion;Address;AIDS prevention;Area;Birth;Black, Indigenous, People of Color;California;Capital;career;Caring;cis-female;cohort;community based participatory research;Community Health Aides;Complement;Constitution;Country;Course Content;Cultural Diversity;Data;design;Development;digital health;Discrimination;Disparity;Education;Employment;Environment;Epidemic;Ethnic Origin;experience;Face;Faculty;Family;Freedom;Future;Gender;gender affirming care;gender-based violence;Generations;Geography;Health;health equity;Health Personnel;HIV;implementation science;Inequity;Infrastructure;Institution;intimate partner violence;Justice;Knowledge;learning materials;Legal;Lived experience;marginalization;Master of Science;Medical Sociology;Methods;mHealth;Minority;Minority Women;next generation;Personal Satisfaction;Persons;pilot test;poor health outcome;Population;Prevalence;Primary Care;programs;Public Health;Public Health Practice;Public Health Students;Race;Reproductive Health;Reproductive Sciences;Research;Research Methodology;Research Personnel;Science;Self Determination;sex;skills;social;social epidemiology;Social status;social structure;Societies;Structure;Students;System;Testing;Time;Training;transgender;transgender women;transmission process;undergraduate student;Universities;virtual;Woman;women of color;Women's Rights;Work;Writing

PROJECT_TITLE: Advancing Gender and Health Justice Research and Education

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CCHI-P (57)]


NIH_SPENDING_CATS: Aging;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;HIV/AIDS;Heart Disease;Immunotherapy;Infectious Diseases;Obesity;Prevention

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative People living with HIV infection have increased inflammation and risk of cardiovascular disease and metabolic disease. Abnormalities in the gastrointestinal tract and in the immune system can increase the risk of cardiovascular and metabolic disease. This proposal would enable the PI to advance research on metabolic and cardiovascular health in people with HIV and to train future physician scientists.

PI_NAMEs: LO, JANET  (contact)

PROGRAM_OFFICER_NAME: JANCI, ELIZABETH WONDERLICH

PROJECT_TERMS: Adipose tissue;Adult;Affect;Aging;Agonist;AIDS clinical trial group;antagonist;antiretroviral therapy;Atherosclerosis;Award;Biological;Biopsy Specimen;Cardiology;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;Cardiovascular system;CCR5 gene;chemokine receptor;Chronic;Clinical;clinical investigation;Clinical Investigator;Clinical Research;Clinical Trials;Collaborations;Communicable Diseases;comorbidity;Conduct Clinical Trials;Data;Data Set;Dedications;Diabetes Mellitus;Double-Blind Method;Dyslipidemias;Education;effective intervention;Epithelium;experience;Functional disorder;Funding;Future;Future Generations;Gastroenterologist;gastrointestinal;Gastrointestinal tract structure;GLP-2;Goals;HIV;HIV Infections;HIV-1;Immune;immune activation;Immune system;Immune Targeting;Immunologist;Immunology;improved;Inflammation;Infrastructure;insight;Insulin Resistance;Interdisciplinary Study;Intervention;intestinal barrier;Intestines;Investigation;Laboratories;Lead;Leadership;Medicine;men;Mentors;Metabolic;Metabolic Diseases;Metabolism;Mid-Career Clinical Scientist Award (K24);mid-career faculty;Midcareer Investigator Award in Patient-Oriented Research;Mucous Membrane;Multi-Institutional Clinical Trial;multidisciplinary;novel;Obesity;Pathologist;Pathology;patient oriented;patient oriented research;Persons;Physicians;Physiological;Placebo Control;Placebos;Population;Prevention strategy;primary endpoint;prospective;Radiology Specialty;Randomized;randomized placebo controlled trial;randomized trial;Research;Research Personnel;research study;Residual state;Risk;RNA;Role;Scientific Advances and Accomplishments;Scientist;skills;teduglutide;Time;Tissue Sample;Training;treatment strategy;United States National Institutes of Health;Woman

PROJECT_TITLE: Effects of Targeting Immune Activation and Intestinal Barrier on Comorbidities in People with HIV

STUDY_SECTION: AIDS

STUDY_SECTION_NAME: Acquired Immunodeficiency Syndrome Research Study Section[AIDS]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Breastfeeding, Lactation and Breast Milk;Clinical Research;Clinical Trials and Supportive Activities;Depression;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Major Depressive Disorder;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Mental Illness;Nutrition;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Serious Mental Illness;Social Determinants of Health;Women's Health Research

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative This project aims to develop and test a perinatal depression intervention using a couple-based approach that involves male partners to provide social support for depression and to prevent transmission of HIV to infants. Our goal is to demonstrate a proof-of-concept for the proposed intervention, which if shown to be feasible and acceptable, may have the potential to reduce depressive symptoms and ultimately, improve adherence to prevention-of-mother-to-child transmission of HIV outcomes for mothers and infants in sub-Saharan Africa.

PI_NAMEs: CONROY, AMY ANNE (contact)

PROGRAM_OFFICER_NAME: SENN, THERESA ELAINE

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;Affect;Africa South of the Sahara;antenatal;antenatal care;antiretroviral therapy;arm;Attention;Attenuated;Breast Feeding;care providers;Caring;Child;Clinic;Communication;Companions;Conflict (Psychology);Contracts;Couples;Data;Data Collection;depressive symptoms;Economics;efficacy trial;Emotional;Enrollment;evidence base;Exclusive Breastfeeding;experience;Family health status;Feedback;Focus Groups;Food;food insecurity;Future;global health;Goals;HIV;implementation evaluation;improved;Individual;Infant;instrument;Intervention;intervention effect;intervention refinement;Intervention Trial;Interview;intimate behavior;intimate partner violence;Kenya;Malawi;male;Manuals;maternal outcome;Mediating;meetings;men;Men's Role;Mental Depression;Mental Health;Methods;Modification;Mother-to-child HIV transmission;Mothers;nutrition;Nutritional;Outcome;perinatal depressive symptom;perinatal women;peripartum depression;Pilot Projects;pilot trial;Postpartum Period;Pregnancy;Pregnant Women;Preparation;prevent;Prevention;primary outcome;Problem Solving;problem solving therapy;Procedures;Process;Prophylactic treatment;Public Health;Randomized;Randomized, Controlled Trials;recruit;Reporting;Research;Resource-limited setting;retention rate;satisfaction;scale up;Series;Services;skills;social;Social support;Source;standard of care;Stress;stressor;successful intervention;Support System;Symptoms;Target Populations;Testing;Therapeutic Intervention;transmission process;Treatment Efficacy;Vertical Disease Transmission;Viremia;virtual;Woman;women's treatment;Work;World Health Organization

PROJECT_TITLE: Addressing Perinatal Depression and PMTCT Adherence in Malawi: A Couple-based Approach


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Immunization;Infectious Diseases;Prevention;Vaccine Related

PHR: Project Narrative We aim to quantify how traditional HIV therapy (ART) and antibodies against HIV (bnAbs) lose efficacy during treatment interruption in people with HIV, for bnAbs, distinguishing between antiviral and potential "vaccine"- like effects. The study will analyze ART levels in plasma, blood cells, and tissues as it relates to viral rebound and changes in reservoirs during ATI, and assess bnAb antiviral activity in human tonsil tissue cells. This research will guide the design of future HIV cure trials, providing essential insights into cure treatment efficacy with broader implications for HIV treatment and prevention.

PI_NAMEs: DEITCHMAN, AMELIA N (contact)

PROJECT_TERMS: Address;Aftercare;AIDS clinical trial group;Anti-Retroviral Agents;Anti-viral Agents;antiretroviral therapy;Binding;Biological Assay;Blood;Blood Cells;booster vaccine;Cells;Clinical;Clinical Trials;Complement;curative treatments;Data;design;DNA;Dose;Drug Kinetics;Evaluation;experimental study;Feedback;Future;Goals;HIV;HIV Antibodies;HIV therapy;Hour;Human;Immune;immune function;Immune response;Immune Targeting;Immunomodulators;in vivo;Inflammatory;insight;Interruption;Intervention;Intervention Studies;Kinetics;Knowledge;Leukapheresis;Link;lymph nodes;Lymphoid Tissue;Measurement;Measures;Mediating;Methods;Microdialysis;Modeling;models and simulation;Monitor;neutralizing antibody;novel;Participant;Peripheral Blood Mononuclear Cell;Persons;Pharmaceutical Preparations;Pharmacodynamics;pharmacologic;Pharmacology;Plasma;Prevention;Publishing;Research;RNA;Sampling;Technology;Therapeutic;Therapeutic Trials;therapy development;Tissue Model;Tissue Sample;Tissues;Tonsil;Tonsillar Tissue;tool;treatment effect;Treatment Efficacy;vaccine-induced antibodies;Vaccines;Viral;Viral Antibodies;Viral Physiology;viral rebound;Viral reservoir;Viral Vaccines;Virus;Work

PROJECT_TITLE: Characterizing Antiviral Washout and Viral Rebound during Analytic Treatment Interruption Studies


ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Finding a cure for HIV/AIDS is challenging because we lack the tools to identify the cells that contain latent proviruses. This proposal seeks to understand how non-productive infections are generated by dissecting viral as well as host contributions using a new technique, which help us find potential markers for HIV latency and targets for a cure.

PI_NAMEs: SIMON, VIVIANA A (contact)

PROGRAM_OFFICER_NAME: REFSLAND, ERIC WILLIAM

PROJECT_TERMS: Automobile Driving;Awareness;Biological Markers;Biology;CD4 Positive T Lymphocytes;Cells;Chronic;Collection;Consensus;cytokine;Data;Data Set;Detection;differential expression;Environment;Epigenetic Process;Frequencies;Gene Expression Profile;Genes;Genetic Transcription;genome editing;Genomic Segment;Goals;Greek;Highly Active Antiretroviral Therapy;HIV;HIV Infections;HIV/AIDS;Human;Immune;Immune system;Immunologic Stimulation;improved;in vivo;Infection;Inflammation;Innate Immune Response;innovation;insight;integration site;Interferons;Invaded;Knowledge;latent infection;Maps;memory CD4 T lymphocyte;Molecular;multidisciplinary;mutant;Names;Outcome;overexpression;Pathway interactions;Patients;Persons;Positioning Attribute;prevent;Productivity;programs;Protein Isoforms;prototype;Proviruses;Refractory;Reporter;Research Priority;Role;Sensitivity and Specificity;Sleep;Sorting;stem cells;Structure;System;T-Lymphocyte;T-Lymphocyte Subsets;Techniques;Testing;Therapeutic Intervention;tool;Transcript;transcriptome;Variant;vector;Viral;viral RNA;Virus;Work

PROJECT_TITLE: Determinants of HIV latency in CD4+ T lymphocytes


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Neurosciences;Orphan Drug;Prevention;Rare Diseases;Tuberculosis

ORG_NAME: UNIVERSITY OF MINNESOTA

PHR: 8. Project Narrative Infections of the central nervous system are a leading cause of HIV-related opportunistic infections globally, resulting in substantial disability and death. This K24 Midcareer Investigator Award in Patient-Oriented Research is focused on the clinical and translational research of neuroinfectious diseases to improve their diagnosis, treatment, and prevention in the United States and abroad.

PI_NAMEs: BOULWARE, DAVID R (contact)

PROGRAM_OFFICER_NAME: MAHON III, ROBERT N

PROJECT_TERMS: Accounting;Acquired Immunodeficiency Syndrome;Adult;Africa;Africa South of the Sahara;Age;aged;AIDS-Related Opportunistic Infections;anti-fungal agents;antimicrobial;Area;Award;biobank;Biological Assay;Biological Markers;brain tissue;career;Caring;Central Nervous System Infections;Cerebrum;Cessation of life;Clinical;clinical care;Clinical Research;clinical trial protocol;clinically relevant;cohort;Communicable Diseases;Country;COVID-19;Creativeness;Cryptococcal Meningitis;Cryptococcosis;Cryptococcus;Decentralization;Detection;Diagnosis;Diagnostic;disability;Disease;Doctor of Philosophy;doctoral student;Educational workshop;Electrolytes;Encephalitis;Enrollment;Faculty;Fire - disasters;Future;Goals;Guidelines;health economics;HIV;HIV therapy;HIV/AIDS;Hospitals;Human;Immune;Immune response;Immune system;Immunologics;improved;Income;innovation;International;Internet;Intracranial Pressure;Leadership;Liquid substance;Manuscripts;Medical;Medicine;Meningeal Tuberculosis;Meningitis;Meningoencephalitis;Mentors;Mentorship;Midcareer Investigator Award in Patient-Oriented Research;Monitor;mortality;multidisciplinary;Nature;neglect;Nervous System Disorder;Neurocognitive;New Agents;novel;novel therapeutics;Organism;Outcome;Outpatients;patient oriented research;Perfusion;Persons;Phase II/III Clinical Trial;Phase III Clinical Trials;phase III trial;Policies;Population;prevent;Prevention;Productivity;programs;prospective;Prospective cohort;Publishing;randomized trial;randomized, clinical trials;Regimen;Research;Research Personnel;Research Proposals;RNA;screening;Seminal;single-cell RNA sequencing;Site;skills;standard of care;Steroids;Students;Supportive care;Testing;tool;Training;transcriptome;Translational Research;Translations;Trust;Tuberculosis;Uganda;Underrepresented Minority;United States;United States National Institutes of Health;Validation;Work

PROJECT_TITLE: Midcareer Mentoring for Clinical Research in HIV/AIDS-related cryptococcal and TB meningitis

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 RCU-A (J1)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cardiovascular;Cerebrovascular;Dementia;Estrogen;Heart Disease;Hypertension;Menopause;Neurodegenerative;Neurosciences;Prevention;Vascular Contributions to Cognitive Impairment and Dementia (VCID);Women's Health Research

ORG_CITY: NEW ORLEANS

ORG_DEPT: PSYCHOLOGY

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: Overall Project Narrative The Program Project will determine if and how estrogens interact with cardiovascular and metabolic health to impact the brain and cognitive aging. Understanding conditions under which administration of estrogens are beneficial or harmful is critical to developing a personalized approach in recommendations for use of menopausal hormone therapy in women.

PI_NAMEs: DANIEL, JILL M (contact)

PROGRAM_OFFICER_NAME: ROBERTS, LUCI

PROJECT_TERMS: Address;Age;Aging;Alzheimer's Disease;Alzheimer's disease risk;Angiotensin II;Animal Model;Anti-Hypertensive Agents;arterial stiffness;Attenuated;blood damage;Blood Pressure;Blood Vessels;Brain;cardiometabolism;Cardiovascular Diseases;cardiovascular disorder prevention;cardiovascular effects;Cardiovascular system;Chronology;Cognition;Cognitive;Cognitive aging;cognitive function;Collaborations;Complement;dementia risk;design;Development;Disease;Disease Progression;Early Diagnosis;Enrollment;ESR1 gene;Estradiol;Estrogen decline;Estrogen Receptors;Estrogens;experimental study;Female;Genetic;Goals;GPER gene;grasp;Health;hormone therapy;Hormones;Hypertension;Impaired cognition;improved;in vivo;innovation;Knowledge;Laboratories;Laboratory Finding;Lead;Life;Long-Evans Rats;Luciferases;menopausal hormone therapy;Menopause;Metabolic;Methods;middle age;Modeling;Molecular;Monitor;mouse model;Mus;neurovascular coupling;novel;Nurses' Health Study;older patient;Organ;Ovariectomy;Perimenopause;personalized approach;Pharmaceutical Preparations;Pharmacology;Postmenopause;pre-clinical;programs;protective effect;Publications;receptor;receptor expression;receptor function;Recommendation;Regulation;Research Personnel;Research Project Grants;Resolution;response;Rodent Model;Role;Signal Pathway;Techniques;Time;Transcript;Transgenic Mice;Transgenic Organisms;ultrasound;Vascular Dementia;Vertebral column;Woman;Women's Health

PROJECT_TITLE: Estrogens, Cardiometabolic Health, and Female Cognitive Aging


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;HIV/AIDS;Infectious Diseases;Neurosciences;Pediatric

ORG_CITY: LOS ANGELES

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Public Health Impact: Noninvasive brain imaging using novel rosette trajectories-based 5D spectroscopic imaging and myelin imaging combined with compressed sensing reconstruction will provide improved knowledge of HIV neuropathogenesis in perinatally HIV-infected young adult survivors. Our approach will reduce the duration required for MR spectroscopic and myelin imaging to a clinically feasible scan time, which will allow the implementation of these novel tools for the assessment of neurofunction in perinatally HIV-infected young adult patients. By characterizing HIV neuropathogenesis to the brain as these youth age, interventions can be developed (such as change of antiretroviral medications) to improve neurologic function, prevent central nervous system deterioration, and improve quality of life. The same technology can be useful in the investigation of neuropathogenesis in other congenital infections.

PI_NAMEs: THOMAS, MICHAEL ALBERT (contact)

PROGRAM_OFFICER_NAME: SRINIVASAN, SUDHA

PROJECT_TERMS: 3-Dimensional;Acceleration;Adult;Age;Age Years;AIDS prevention;Algorithms;Anti-Retroviral Agents;antiretroviral therapy;Applications Grants;Aspartate;Assessment tool;Axon;Brain;brain abnormalities;brain health;Brain imaging;Brain Injuries;caudate nucleus;CD4 Lymphocyte Count;Central Nervous System;Cerebrum;Child;Choline;Chronic Brain Injury;chronic infection;Clinical;clinical application;Code;Cognitive;comparison control;congenital infection;Corpus Callosum;Creatine;Data;design;Deterioration;Dimensions;Disease;effectiveness evaluation;efficacy evaluation;Epidemic;Evaluation;executive function;Exposure to;Future;Glutamates;Glutathione;Goals;gray matter;Hippocampus;HIV;HIV therapy;HIV/AIDS;Home;Image;Imaging Techniques;Imaging technology;improved;improved outcome;in vivo;Individual;Intervention;Investigation;Knowledge;lateral ventricle;Lead;Location;Long-Term Effects;Longitudinal Studies;Magnetic Resonance Imaging;magnetic resonance spectroscopic imaging;Magnetic Resonance Spectroscopy;Measurement;Measures;Medical Imaging;Metabolic;Motion;motor impairment;Myelin;Myelin Water Imaging;myelination;myoinositol;Nervous System Physiology;neurochemistry;Neurocognitive;Neurocognitive Deficit;neurocognitive test;neuroimaging;Neuropathogenesis;Neuropsychological Tests;Neuropsychology;non-invasive imaging;novel;Outcome;Pathogenesis;Patients;pediatric human immunodeficiency virus;Performance;Perinatal;perinatal brain;perinatal HIV;Peripheral;Persons;Pharmaceutical Preparations;Play;Population;preservation;prevent;prisma;Protocols documentation;Public Health;Quality of life;Radial;reconstruction;Reporting;Resolution;Role;Sampling;Scanning;Scheme;scyllo-inositol;sex;Signal Transduction;Slice;spectroscopic imaging;Spectrum Analysis;Survivors;Techniques;Technology;Testing;Thick;Time;tool;two-dimensional;Vertical Transmission;Viral;Viral Load result;Virus Diseases;Water;white matter;young adult;Youth

PROJECT_TITLE: Accelerated Rosette Trajectories- Based 5D MR Spectroscopic Imaging AND MR Imaging of Myelin Fraction in Perinatally HIV-Infected Adults

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


NIH_SPENDING_CATS: Biotechnology;HIV/AIDS;Immunization;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: LA JOLLA

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

PHR: Project Narrative. The induction of broadly neutralizing antibodies (bnAbs) by vaccination is a global health priority as a means to prevent HIV infection, and the membrane proximal external region (MPER) of the HIV-1 envelope protein is a site of particular interest. Vaccine induction of bnAbs will likely require sequential immunization with additional immunogens designed to shepherd affinity maturation of the B cell receptor (BCR) to acquire neutralization breadth and potency. This project seeks to develop soluble and membrane-bound boost immunogens that present the MPER epitope in a more native-like context with the aim of maturing primed BCRs to acquire bnAb features.

PI_NAMEs: SWANSON, OLIVIA  (contact)

PROGRAM_OFFICER_NAME: MALASPINA, ANGELA

PROJECT_TERMS: Affinity;Animal Model;Antibodies;Antibody Response;Antigens;B-Cell Activation;B-Cell Antigen Receptor;B-Lymphocytes;Binding;Biophysics;Cells;Complex;Computer Models;Conserved Sequence;design;Development;Directed Molecular Evolution;Engineering;Ensure;env Gene Products;Epitopes;Flow Cytometry;Germ Lines;Germ-Line Mutation;global health;Goals;Health Priorities;HIV;HIV envelope protein;HIV Envelope Protein gp120;HIV Infections;HIV-1;Human;Immunity;Immunization;immunogenic;immunogenicity;Immunoglobulin Somatic Hypermutation;Immunology;Individual;interest;Knock-in Mouse;Lead;Length;Mature B-Lymphocyte;Membrane;Membrane Lipids;Mentors;Messenger RNA;Modeling;mRNA delivery;Mus;Mutate;Mutation;nanoparticle delivery;neutralizing antibody;nonhuman primate;Passive Immunization;Polishes;prevent;Process;Proteins;recruit;Research;research and development;Resources;response;Route;scaffold;Site;skills;structural biology;Structure;Structure of germinal center of lymph node;Testing;Training;Vaccination;vaccine development;Vaccines;viral resistance;Work

PROJECT_TITLE: Development of soluble and membrane bound immunogens to shepherd HIV-1 MPER specific BCR maturation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F17A-F (20)]