NIH_SPENDING_CATS: Aging;Chronic Obstructive Pulmonary Disease;Eye Disease and Disorders of Vision;Lung;Macular Degeneration;Neurodegenerative;Neurosciences

ORG_CITY: CHARLESTON

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: Studies have shown that oxidative stress, elastin-layer breakdown, antibody production and complement activation are fundamental components of age-related macular degeneration (AMD). Our preliminary studies in cell and animal models of disease, suggest that elastase activity might be involved in complement activation, potentially playing a role in the pathobiology of AMD. We have designed experiments to explore the roles of elastase and elastin-fragments as well as the elastase inhibitor alpha-1 anti trypsin in RPE function and health.

PI_NAMEs: ROHRER, BAERBEL  (contact)

PROJECT_TERMS: Acceleration;Acute;Age;Age of Onset;Age related macular degeneration;Air;alpha 1-Antitrypsin;Animal Disease Models;Animal Model;Antibodies;Antibody Formation;antibody-dependent cell cytotoxicity;Autoimmune Responses;B-Lymphocytes;Basement membrane;Binding;Blindness;Bruch's basal membrane structure;Cell model;cell motility;Cell surface;Choroidal Neovascularization;Complement;Complement 1q;Complement Activation;complement system;Complement-Dependent Cytotoxicity;Data;Databases;design;Disease;Disease Progression;elastase inhibitor;Elastases;Elasticity;Elastin;Endothelial Cells;Enzymes;Epithelium;Event;Exhibits;Experimental Designs;exposure to cigarette smoke;Extracellular Matrix;Eye;gene complementation;Goals;Health;Homeostasis;human subject;Immunize;immunogenic;Immunoglobulin G;Inflammation;Injury;innovation;intraperitoneal;Lasers;Lectin;Lesion;Ligands;Lung;lung injury;macula;man;Modeling;Modification;Molecular Abnormality;mouse model;Mus;neoantigens;Ocular Pathology;Oxidative Stress;Pathologic;Pathology;Pathway interactions;Patients;Peptides;preservation;Process;Production;Proteins;Pulmonary Emphysema;Rag1 Mouse;receptor;Reporting;response;Role;Serum;Signal Transduction;Smoke;Stress;Surface;T-Lymphocyte;Testing;Therapeutic;therapeutic development;Therapeutic Effect;Thick;Thinness;Transgenic Mice;Vascular Endothelial Growth Factors;Vision

PROJECT_TITLE: Elastase and Elastin Peptide Activity in Age-Related Macular Degeneration

STUDY_SECTION: DPVS

STUDY_SECTION_NAME: Diseases and Pathophysiology of the Visual System Study Section[DPVS]


ADMINISTERING_IC: EY

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF OPTOMETRY/OPHT TECH

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision

ORG_CITY: BLOOMINGTON

ORG_COUNTRY: UNITED STATES

ORG_DEPT: OPHTHALMOLOGY

ORG_FIPS: US

ORG_NAME: TRUSTEES OF INDIANA UNIVERSITY

ORG_STATE: IN

PHR: Project Narrative Despite decades of study, cataracts, defined as any opacity in the eye lens, remain the leading cause of blindness in the world while unaddressed presbyopia, caused by an age-related reduction in the lens’ ability to change shape during focusing (accommodation), is the leading cause of visual impairment globally. Recent work and our new data have linked dysfunction of Eph-ephrin bidirectional signaling pathway to age-related changes in lens transparency and biomechanical properties. The goal of this project is to elucidate the role for Eph-ephrin signaling in maintaining life-long lens transparency and homeostasis and to understand how these molecules regulate cell-cell adhesion, cytoskeletal structures and cell-cell communication in lens epithelial and fiber cells.

PI_NAMEs: CHENG, CATHERINE KEHSIN (contact)

PROGRAM_OFFICER_NAME: ARAJ, HOUMAM H

PROJECT_TERMS: Affect;Age;age related;age related changes;Aging;Agonist;antagonist;Anterior;Biochemical;Biomechanics;Blindness;Cataract;Cell Adhesion Molecules;Cell Communication;Cell Differentiation process;Cell Maturation;Cell membrane;Cell Nucleus;Cell-Cell Adhesion;Cells;Confocal Microscopy;Crystalline Lens;Cytoskeleton;Data;Development;Disease;Electron Microscopy;Eph Family Receptors;EphA2 Receptor;Ephrin-A5;Ephrins;Epithelial Cells;epithelial to mesenchymal transition;Fiber;fiber cell;Functional disorder;Glass;Goals;Growth;Homeostasis;Human;Immunofluorescence Immunologic;In Vitro;in vitro Model;Knock-out;Lead;lens;lens cortex;Lens development;Lens Opacities;lens transparency;Ligand Binding;Ligands;Link;Maps;Mass Spectrum Analysis;Measures;Mediating;Molecular;Morphology;mouse model;Mus;Mutation;normal aging;Normal Cell;Nuclear;Nutrient;Optics;Pathology;Pathway interactions;Patients;Pattern;Peptides;Peripheral;Phosphorylation;Phosphotransferases;Play;Population;Presbyopia;prevent;Property;Reading;receptor;Refractive Indices;Reporting;Role;segregation;Serine;Shapes;Signal Pathway;Signal Transduction;Signaling Molecule;Structure;superresolution microscopy;Tissues;Tyrosine;ultra high resolution;Vision;Visual impairment;wasting;Work;World Health Organization

PROJECT_TITLE: Eph-ephrin signaling in the lens

STUDY_SECTION: BVS

STUDY_SECTION_NAME: Biology of the Visual System Study Section[BVS]


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Obesity;Clinical Research;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Obesity;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: WINSTON-SALEM

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

ORG_STATE: NC

PHR: NARRATIVE Youth-onset type 2 diabetes (T2D) is associated with a more severe disease phenotype, with reduced responsiveness to adult-onset T2D treatment approaches and increased risk of earlier onset disease- associated complications. Identifying pathophysiologic factors associated with the development of youth-onset T2D is critical to identifying opportunities for disease prevention. This study includes operational and scientific aims designed to support recruitment and retention of youth at high risk of developing T2D, in support of a common protocol for a Consortium-based, multisite longitudinal cohort study of youth-onset T2D.

PI_NAMEs: JENSEN, ELIZABETH T (contact);TURLEY, CHRISTINE B.

PROGRAM_OFFICER_NAME: BROADNEY, MIRANDA MARGUERITE

PROJECT_TERMS: 13 year old;Acceleration;Address;Adolescence;Adolescent;Adult;American Indians;Ancillary Study;arterial stiffness;Behavioral;biobank;Black race;blood glucose regulation;Body mass index;Childhood;Clinical;clinical center;Clinical Research;clinical research site;Clip;cohort;Collection;Communities;community organizations;comorbidity;Data;Data Collection;Dedications;design;Development;Diabetic Nephropathy;Diet;Disease;Disease Pathway;disease phenotype;disorder prevention;Dissemination and Implementation;early onset;Enrollment;Environmental Risk Factor;Epigenetic Process;ethnic diversity;ethnic minority population;Ethnic Origin;euglycemia;experience;Family;Feces;Functional disorder;Future;gene environment interaction;Genetic;Genetic Predisposition to Disease;Genotype;Hair;health determinants;Health Services Accessibility;Health system;high risk;Hypertension;Impairment;Incidence;Individual;insulin sensitivity;Life;Life Cycle Stages;Lived experience;Longitudinal cohort study;marginalization;Mediator;medical specialties;member;Minority Groups;Non-Insulin-Dependent Diabetes Mellitus;Not Hispanic or Latino;Obesity;Onset of illness;Overweight;Participant;Pathogenesis;Patients;Peripheral Nervous System Diseases;Phenotype;Physical activity;Physiological;Plasma;Population;Population Heterogeneity;Prediabetes syndrome;Predisposition;prepuberty;Prevalence;Prevention approach;Primary Care;protective factors;Protocols documentation;Puberty;puberty transition;Race;racial diversity;racial minority population;racism;Recording of previous events;recruit;Reporting;Research;Research Design;Research Infrastructure;Research Personnel;Resources;retention rate;Retinal Diseases;Risk;Risk Factors;Sampling;SEARCH for Diabetes in Youth;Serum;Site;social;Southeastern United States;Specimen;Stigmatization;Structure of nail of toe;therapeutic target;Tooth structure;Underrepresented Minority;Urine;Weight;Work;Youth

PROJECT_TITLE: Illuminating the path(ophysiology) to development of youth-onset type 2 diabetes (PATH-NC)


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: Aurora

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Pulmonary hypertension (PH) is a progressive disease with a high mortality rate due to ultimate right ventricular (RV) dysfunction and failure. The overall hypothesis of this project is that a cascade of RV fiber re-orientation and changes in LV contractile mechanics are potential targets to halt or reverse functional decline, which have not been explored. The successful completion of this project would confirm that these are targets worth pursuing and reveal the potential transcriptional and structural changes that could be exploited.

PI_NAMEs: KHEYFETS, VITALY  (contact)

PROGRAM_OFFICER_NAME: LIN, SARA

PROJECT_TERMS: Adopted;Animals;aorta constriction;Biological;Cardiac;Cardiac Myocytes;Catheterization;Cause of Death;Characteristics;Child;clinical practice;Collagen;Computer Models;connectin;Contracts;coping;Coupling;Data;Data Set;Death Rate;Deterioration;Diffusion;Energy Transfer;Failure;Female;Fiber;Fibrosis;Focal Adhesions;functional decline;Future;Gender;Gene Expression;Genes;Genetic Transcription;Geometry;Heart;Image;improved;improved outcome;in silico;innovation;Interruption;Left;Left ventricular structure;Lung;Machine Learning;Magnetic Resonance Imaging;male;Matrix Metalloproteinases;mechanical energy;mechanical stimulus;Mechanical Stress;Mechanics;Modeling;mouse model;Mus;Myocardial;Myosin Heavy Chains;Observational Study;Operative Surgical Procedures;Pathway interactions;Patient-Focused Outcomes;Physiologic intraventricular pressure;preservation;pressure;Process;Progressive Disease;protein expression;Protein Isoforms;Pulmonary Heart Disease;Pulmonary Hypertension;pulmonary vascular disorder;Pump;Research;response;Right Ventricular Dysfunction;right ventricular failure;Right Ventricular Function;right ventricular remodeling;Right ventricular structure;Role;Signal Transduction Pathway;simulation;Stress;Systole;targeted treatment;therapeutic target;Time;Tissues;Torsion;Ventricular;Ventricular Ejection Fractions

PROJECT_TITLE: What triggers RV Fiber Re-Orientation in response to RV pressure overload, and what is its Consequence on Inter-Ventricular Decoupling?

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Immunization;Immunotherapy;Neurosciences;Orphan Drug;Prevention;Rare Diseases;Vaccine Related

ORG_CITY: CHICAGO

ORG_DEPT: NEUROSURGERY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Immunotherapy is a promising approach to treat glioblastoma patients, yet its efficacy so far has been very limited. Our work provides an opportunity to explore the B-cell-based vaccine as immunotherapy to treat deadly tumors, including glioblastoma. Our approach utilizes 4-1BBL+ B cells as a cellular platform to promote anti-tumor immunity.

PI_NAMEs: LEE CHANG, CATALINA  (contact)

PROGRAM_OFFICER_NAME: CARDONE, MARCO

PROJECT_TERMS: Animals;anti-PD-L1;Antibodies;Antibody Formation;Antigen Presentation;Antigens;APC Vaccine;Authorization documentation;Autologous;B cell differentiation;B-Cell Activation;B-Cell Antigen Receptor;B-Cell Development;B-Lymphocytes;Brain;cancer immunotherapeutics;CD8-Positive T-Lymphocytes;CD86 gene;CD8B1 gene;Cell Therapy;Cells;Cellular Immunity;Characteristics;Circulation;Clinic;clinical application;cost;Cross Presentation;cytokine;cytotoxic;cytotoxicity;Data;Dendritic Cells;design;efficacy study;Ensure;Evaluation;experimental study;Future;Generations;Glioblastoma;Glioma;Goals;Humoral Immunities;IgG1;Immune;immune checkpoint blockade;Immunity;Immunologics;Immunosuppression;Immunotherapeutic agent;Immunotherapy;in vivo;Infiltration;Interferon Type II;Interleukin-15;Investigational New Drug Application;Knowledge;Mediating;Memory;Metabolic;MHC Class I Genes;migration;Mus;Myelogenous;novel;Patients;PD-L1 blockade;peripheral blood;phase 1 designs;Phase I Clinical Trials;preclinical efficacy;preclinical study;preclinical toxicity;prevent;Prevention;Process;Production;Radiation;Research;research clinical testing;Research Proposals;secondary lymphoid organ;Specificity;T cell infiltration;T memory cell;T-Cell Activation;T-Lymphocyte;Testing;Therapeutic;Therapeutic antibodies;TNFRSF5 gene;Toxicology;Translating;Treatment Protocols;tumor;Tumor Antigens;tumor eradication;tumor growth;Tumor Immunity;vaccine immunotherapy;Vaccine Production;Vaccines;Work

PROJECT_TITLE: Development of B-cell-based vaccine for Glioblastoma

STUDY_SECTION: CII

STUDY_SECTION_NAME: Cancer Immunopathology and Immunotherapy Study Section[CII]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: DURHAM

ORG_DEPT: CHEMISTRY

ORG_NAME: DUKE UNIVERSITY

PHR: Nedd4 is an enzyme that transfers ubiquitin to protein targets, a modification that recently emerged as a significant regulator of a-synuclein proteotoxicity in addition to its previously known function in cancer. A recently discovered small molecule has been shown to reverse this toxicity in a Nedd4-dependent manner. In this proposal we wish to gain insight into the molecular basis of the small molecule interaction with Nedd4, which may inspire the development of new therapeutics to treat synucleinopathies like Lewy body dementia and Parkinson’s disease.

PI_NAMEs: MCCAFFERTY, DEWEY G (contact)

PROGRAM_OFFICER_NAME: BARSKI, OLEG

PROJECT_TERMS: Address;alpha synuclein;Binding;Binding Sites;Biology;Brain;Cell model;Cell Physiology;Chemicals;Communication;Development;Disease;enzyme activity;Enzymes;Family;Future;gain of function;Glues;Golgi Apparatus;Induced Neurons;insight;Knowledge;Label;Lewy Body Dementia;Ligase;Location;Malignant Neoplasms;member;Methods;Modification;Molecular;Multienzyme Complexes;Neurodegenerative Disorders;Neuroglia;Neurons;novel therapeutics;Parkinson Disease;Pathway interactions;Phenotype;Play;Post-Translational Protein Processing;precursor cell;Process;Proteins;proteostasis;proteotoxicity;response;Role;screening;Signal Transduction;small molecule;Structure;Substrate Specificity;synucleinopathy;Testing;therapeutic development;Toxic effect;trafficking;Ubiquitin;ubiquitin-protein ligase;Ubiquitination

PROJECT_TITLE: Chemical Biology of the E3 Ubiqutin Ligase Nedd4

STUDY_SECTION: SBCB

STUDY_SECTION_NAME: Synthetic and Biological Chemistry B Study Section[SBCB]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Brain Disorders;Complementary and Integrative Health;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: NEW YORK

ORG_DEPT: NEUROLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: Narrative Coenzyme Q (CoQ), a lipophillic molecule present in virtually all cell membranes, is synthetized through the mevalonate pathway, which is also responsible for the synthesis of cholesterol. Alterations in cholesterol metabolism result in neuronal dysfunction. CoQ deficiency has been associated with multiple system atrophy (MSA), the most common cause of adult-onset neurodegenerative ataxia. In this application, we aim to establish the role of CoQ deficiency and consequent alterations in cholesterol metabolism in the pathogenesis of MSA, to unveil novel pathways of neurodegeration, and discover potential therapeutic targets for MSA and other neurodegenerative diseases.

PI_NAMEs: QUINZII, CATARINA M. (contact)

PROGRAM_OFFICER_NAME: FU, YI-PING

PROJECT_TERMS: Adult;Affect;Anabolism;Astrocytes;Ataxia;Biochemical;Biology;Cell Death;Cell membrane;Cell model;Cells;Chemicals;Cholesterol;cholesterol biosynthesis;Cholesterol Homeostasis;Coenzyme Q10;cofactor;Data;Defect;Disease;Down-Regulation;Enzymes;Equilibrium;Etiology;extracellular;Functional disorder;Genes;Homeostasis;Human;hydroxybenzoate;Impairment;Induced pluripotent stem cell derived neurons;Link;Lipids;Lipoproteins;Measures;Membrane;membrane activity;Membrane Microdomains;Metabolic Pathway;mevalonate;Mitochondria;Molecular;Morphology;Multiple System Atrophy;Mutation;Nerve Degeneration;Neurodegenerative Disorders;Neuronal Dysfunction;Neurons;new therapeutic target;novel;overexpression;Oxidative Phosphorylation;Pathogenesis;Pathogenicity;Pathway interactions;Patients;prevent;Production;Proteins;Publishing;Regulation;Reporting;Role;Supplementation;therapeutic target;trafficking;Transferase;Ubiquinone;ultra high resolution;Up-Regulation;virtual;Yeasts

PROJECT_TITLE: Abnormalities of cholesterol metabolism in multiple system atrophy

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: PHILADELPHIA

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: NARRATIVE – mVACS PROGRAM C. difficile infection is a global health problem, but fully effective vaccines are not available. The "mRNA Vaccines for C. difficile Suppression” program (mVACS) seeks to engineer vaccines based on modified mRNA technology that effectively prevents C. difficile infection and disease. Already program members, working with our corporate partner, have produced promising multivalent vaccines that are highly active in mice—research in the program will fully optimize and implement this exceptionally promising platform.

PI_NAMEs: BUSHMAN, FREDERIC D (contact);WEISSMAN, DREW

PROGRAM_OFFICER_NAME: RANALLO, RYAN

PROJECT_TERMS: 2019-nCoV;adaptive immune response;anti-toxin;Antibiotics;Antigens;archive data;Bioinformatics;Biological Response Modifier Therapy;Biology;Cessation of life;Clinical;Clostridioides difficile vaccine;Clostridium difficile;Colitis;Collaborations;Data;data archive;Dedications;design;Development;Diarrhea;Disease;Dose;Ecology;Engineering;Environment;Formulation;Gastrointestinal Diseases;Genomics;global health;Goals;gut colonization;Human;Immune;Immune response;Immunize;Immunology;improved;Individual;industry partner;Infection;insight;Intervention;Intestines;Lead;Lipids;Literature;member;Membrane Proteins;Messenger RNA;Metadata;Methods;microbial;Microbiology;microbiota;mouse model;Mucosal Immune Responses;Mucosal Immunity;Mucous Membrane;Mus;nanoparticle;novel;novel therapeutic intervention;novel vaccines;Nucleic acid sequencing;Nutrient;pathogen;Pathogenesis;patient population;Phase I Clinical Trials;prevent;Primary Infection;Primary Prevention;Production;programs;Public Health;rational design;Recurrence;recurrent infection;Reporting;Research;response;Risk;RNA vaccine;sample archive;Sampling;Series;Severities;Shapes;skills;System;Technology;Testing;Toxin;transmission process;United States;Vaccinated;Vaccination;vaccine candidate;vaccine delivery;Vaccine Design;vaccine development;vaccine efficacy;vaccine formulation;vaccine platform;Vaccines;Work

PROJECT_TITLE: mVACS--mRNA Vaccines for C. difficile Suppression


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Digestive Diseases;Emerging Infectious Diseases;Immunization;Infectious Diseases;Prevention;Vaccine Related

PI_NAMEs: WEISSMAN, DREW  (contact)

PROJECT_TERMS: Academia;Acceleration;adaptive immune response;Antigens;Budgets;career development;Clinical;Clostridioides difficile vaccine;Clostridium difficile;cohort;Communication;COVID-19 vaccine;Data;data exchange;data integration;Data Set;deep sequencing;design;Disease;Ecology;Electronics;Elements;Ensure;experience;experimental study;Faculty;Feedback;Florida;Fostering;Funding;Genomic approach;Genomics;Goals;Growth;Guidelines;Immune response;Immunization;Immunology;industry partner;Infection;Institution;International;Lead;Leadership;Letters;Measures;meetings;member;Mentors;Messenger RNA;microbial;Monitor;mouse model;Mucous Membrane;North Carolina;novel;Patients;Pediatric Hospitals;Pennsylvania;Persons;Philadelphia;prevent;programs;recruit;Research Activity;Research Personnel;Resource Sharing;Resources;RNA vaccine;Sampling;Structure;Supervision;symposium;Technical Expertise;Testing;Toxin;Training;United States National Institutes of Health;Universities;vaccine development;vaccine platform;Vaccines;vaccinology;virtual;Work

PROJECT_TITLE: Core A: Administrative


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Attention Deficit Hyperactivity Disorder (ADHD);Autism;Behavioral and Social Science;Brain Disorders;Clinical Research;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Prevention

ORG_CITY: SAINT LOUIS

ORG_DEPT: PSYCHIATRY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative Previous research strongly suggests that most autistic syndromes in the population arise from permutations and combinations of a discrete group of independent neurodevelopmental liabilities, some specific to autism, some not. Interventions which target these contributing neurodevelopmental liabilities in an individual before autism develops may offer the greatest opportunity for high-impact, personalized early intervention. In this program, we will validate novel, sensor-based methods for first-year-of-life measurement of two major liabilities: hyperactivity and impairment in motor coordination, which account for over a third of recurrence risk for autism in families, but which are not yet reliably measurable in infancy in a manner that can be implemented in general population screening or in developmental research.

PI_NAMEs: LANG, CATHERINE ;LIMPEROPOULOS, CATHERINE ;MARRUS, NATASHA  (contact)

PROGRAM_OFFICER_NAME: GILOTTY, LISA

PROJECT_TERMS: Accelerometer;Age;Age Months;aged;Attention deficit hyperactivity disorder;Attentional deficit;autism spectrum disorder;autism symptoms;autistic;autistic children;Basal Ganglia;behavioral outcome;behavioral phenotyping;Bilateral;Brain;Cerebellar Diseases;cerebellar lesion;Cerebellum;Child;Clinical;cohort;comorbidity;Data;data analysis pipeline;Data Collection;de novo mutation;Development;developmental disease;Developmental Therapeutics Program;Diagnosis;early childhood;Early Intervention;endophenotype;Family;First Degree Relative;Future;General Population;Genes;Genetic;Genetic Risk;Goals;Heritability;high risk;Hyperactivity;Image;Impairment;indexing;Individual;infancy;Infant;Inherited;Injury;insight;Intervention;Intervention Studies;Joints;Life;Measurable;Measurement;Measures;Mediating;Methodology;Methods;model of autism spectrum disorder;Modeling;Motor;motor behavior;Motor Cortex;motor deficit;Movement;neuroimaging;novel;Outcome;Parents;Performance;personalized intervention;Phenotype;Population;premature;Premature Infant;Prevalence;programs;Publishing;Recurrence;Reporting;Research;Rest;Risk;Risk Factors;Sampling;School-Age Population;screening;secondary analysis;segregation;sensor;social;Social Behavior;Social outcome;Specific qualifier value;Structure;symptomatology;Syndrome;Testing;Time;Toddler;trait;Transgenic Animals;Twin Multiple Birth;Upper Extremity;Variant;Visual;visual tracking;wearable device;wearable sensor technology;Work;Wrist

PROJECT_TITLE: Variation in early motor function in autism, cerebellar injury and normal twins

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Digestive Diseases;Emerging Infectious Diseases;Genetics;Human Genome;Immunization;Infectious Diseases;Microbiome;Prevention;Vaccine Related

PI_NAMEs: BUSHMAN, FREDERIC D (contact)

PROJECT_TERMS: Affect;Antigens;archive data;Archives;Bacteriophages;Bioinformatics;Canis familiaris;Cattle;Cells;Clinical;Clostridioides difficile vaccine;Clostridium difficile;Collaborations;Comparative Study;Data;data archive;data management;design;diverse data;DNA;DNA Modification Process;DNA Sequence Alteration;fascinate;Gene Expression Profiling;Genes;Genetic Variation;Genome;Genomics;Human;Hybrids;Immune response;Immunodeficient Mouse;Immunology;in vivo;Infection;interest;Intestines;Investigation;Membrane Proteins;Messenger RNA;metatranscriptomics;Methods;microbiome;microbiome composition;microbiome sequencing;model organism;Mus;Outcome;Population;Population Heterogeneity;Protein Analysis;protein structure;Proteins;Reporting;Resources;response;RNA vaccine;Sampling;Sequence Analysis;Statistical Data Interpretation;statistics;stool sample;Structure;System;transcription factor;transcriptome sequencing;transposon/insertion element;Vaccinated;vaccine candidate;vaccine efficacy;Vaccines;Variant;Work

PROJECT_TITLE: Core B. Genomics and Bioinformatics Core


NIH_SPENDING_CATS: Asthma;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Dietary Supplements;Genetics;Lung;Natural Products;Nutrition;Pediatric;Prevention;Social Determinants of Health

ORG_NAME: LURIE CHILDREN'S HOSPITAL OF CHICAGO

PHR: Narrative: Pediatric asthma, against which there are no proven prevention strategies, results in significant cost to families and society ($5.92 billion annually) with increased risks emergency department visits, hospitalization, and missed work/school. Soy Isoflavones for Inner City Infants at Risk for Asthma (SIRA) is a precision medicine study, directed to a functional genetic variation in the PAI-1 gene which is present in 60% of the population, that seeks to determine if soy genistein, a safe and inexpensive nutritional product given in the same doses found in soy formula, can decrease the risk of developing allergic airway inflammation and allergies in young infants with this genetic variant. If the study confirms these effects, it would lead into intervention trials focused on asthma prevention, and has the potential to benefit a large number of children at risk of developing asthma.

PI_NAMEs: KUMAR, RAJESH  (contact)

PROGRAM_OFFICER_NAME: DONG, GANG

PROJECT_TERMS: Absenteeism;Absenteeism at work;active method;Affect;Age;Age Months;aged;airborne allergen;airway epithelium;airway inflammation;airway remodeling;Alleles;Allergic;allergic airway inflammation;Anti-viral Response;Asthma;asthma exacerbation;asthma prevention;asthmatic airway;Attenuated;Canis familiaris;CCL17 gene;CCL24 gene;Cells;chemokine;Child;Childhood Asthma;Clinical;cohort;cost;crosslink;cytokine;Dendritic Cells;Development;Dictyoptera;Dietary Administration;Dose;Emergency department visit;Enrollment;eosinophil;Eosinophil cationic protein;Eosinophilia;Epithelial Cells;experimental study;Family;Feedback;Felis catus;gain of function;Gene Expression;Gene Proteins;Genes;Genetic Polymorphism;genetic variant;Genetic Variation;Genistein;Genotype;Heterozygote;high risk infant;Homo;Hospitalization;Human;Hypersensitivity;IgE;Immunoglobulin Class Switching;improved;Individual;indoor allergen;Infant;Inflammation;Influentials;Ingestion;inhibitor;inner city;Interferon alpha;Interferon Type I;Interruption;Intervention;Intervention Trial;Lead;Life;Masks;mast cell;Measures;Medical;nasal swab;Nose;Nutritional;omalizumab;Outcome;Pathway interactions;Pattern;periostin;Peripheral Blood Mononuclear Cell;placebo group;Placebos;Plasma;Plasminogen Activator Inhibitor 1;Population;precision medicine;Prevention;Prevention strategy;primary outcome;Production;promoter;prospective;pulmonary function;Randomized;recruit;Research Project Grants;respiratory;respiratory morbidity;response;restoration;Rhinovirus;Risk;risk variant;Sampling;Schools;Seasons;secondary outcome;Serum;Small inducible cytokine A24;Societies;soy;soy protein isolate;Supplementation;Surface;Th2 Cells;Time;TLR3 gene;TSLP gene;Viral;Viral Load result;Virus;Visit;Work


NIH_SPENDING_CATS: Brain Disorders;Cerebrovascular;Congenital Structural Anomalies;Genetics;Neurosciences;Pediatric;Stroke

ORG_CITY: NEW HAVEN

ORG_DEPT: PATHOLOGY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE About 1 in 100 to 200 people have cerebral cavernous malformations (CCM) with increased risk for stroke, seizures and focal neurological deficits. We will employ genetic, biochemical, cell biology, two-photon microscopy imaging and single cell transcriptome analyses to test the role of intracellular caveolae vesicle and Tie2 receptor signaling in cerebral vascular malformation. Successful completion of our aims will facilitate our understanding of the pathogenesis and molecular mechanisms involved in acquisition of CCM, and help in defining more effective therapies.

PI_NAMEs: ZHOU, JENNY HUANJIAO (contact)

PROGRAM_OFFICER_NAME: CHARETTE, MARC F

PROJECT_TERMS: Adult;Affect;angiogenesis;Angiopoietin-2;Angiopoietins;autosome;Binding;Biochemical;Blood - brain barrier anatomy;Blood brain barrier dysfunction;Blood capillaries;Blood Vessels;blood-brain barrier function;Brain;brain endothelial cell;Brain Vascular Malformation;Caveolae;caveolin 1;Cavernous Malformation;CCM1 gene;Cells;Cellular biology;cerebral cavernous malformations;cerebrovascular;Cerebrovascular system;Chronic;Clathrin;Core Protein;Data;Defect;Disease;Disease Progression;effective therapy;Endocytosis;Endothelial Cells;Endothelial Growth Factors;Endothelium;Exhibits;Exocytosis;experimental study;Focal Neurologic Deficits;Gene Expression;General Population;Genes;Genetic;germinal center kinases;Human;Image;in vitro Model;Inherited;inhibitor;Intercellular Junctions;Lesion;loss of function mutation;malformation;Mediating;Mesenchymal;microscopic imaging;Molecular;mouse model;Mus;Mutation;Nature;neurovascular unit;novel;Pathogenesis;Pathologic;Pathway interactions;Patients;Pericytes;Perinatal;Permeability;Persons;Phenotype;postcapillary venule;prevent;Primary Lesion;protein transport;Proteins;Receptor Signaling;Role;Seizures;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Stress Fibers;stroke risk;Structure;Supporting Cell;Surface;Surgical Replantation;Testing;Therapeutic Effect;therapeutic evaluation;TIE-2 Receptor;Tissues;trafficking;transcriptome;transcytosis;two photon microscopy;two-photon;Vesicle;Visualization;Work

PROJECT_TITLE: Investigating the intracellular vesicle-mediated mechanism contributing to cerebral cavernous malformation

STUDY_SECTION: VCMB

STUDY_SECTION_NAME: Vascular Cell and Molecular Biology Study Section[VCMB]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Brain Disorders;Genetics;Neurosciences

ORG_CITY: STANFORD

ORG_DEPT: BIOLOGY

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: Narrative Understanding how neural circuits are assembled during normal development is a prerequisite for understanding many human neurological and psychiatric disorders that disrupt this assembly process. Some of the human versions of genes that we have discovered in flies to play important roles in neural circuit wiring are implicated in disorders of the brain, including peripheral neuropathy, bipolar disorders, and intellectual disabilities. In addition, knowledge of insect olfactory system organization and development can be used to design strategies to combat malaria, which is transmitted by mosquitos that primarily utilize olfaction to find both their mates and human hosts.

PI_NAMEs: LUO, LIQUN  (contact)

PROGRAM_OFFICER_NAME: SULLIVAN, SUSAN L

PROJECT_TERMS: alpha-latrotoxin receptor;Animals;Axon;Behavior;Biological Assay;Bipolar Disorder;Brain;Brain Diseases;Cell surface;Cell Surface Proteins;Cell Surface Receptors;cell type;Cells;Color;combat;Culicidae;Cytoplasm;Data;Dendrites;design;Development;differential expression;Drosophila genus;Etiology;Event;fly;Genes;Genetic;genetic manipulation;Grant;Hippocampus;Horns;Human;Image;in vivo;Individual;Insecta;insight;Intellectual functioning disability;Invaded;Knowledge;Label;Lateral;Lead;Ligands;Lobe;Malaria;Mammals;Maxilla;Mediating;Mental disorders;Methods;Modeling;Molecular;Mus;Mushroom Bodies;mutant;Nervous System Disorder;neural circuit;Neurobiology;neuromechanism;neuronal cell body;Neurons;Olfactory Learning;Olfactory Pathways;olfactory receptor;Olfactory Receptor Neurons;Organ;Partner in relationship;Pattern;Peripheral;Peripheral Nervous System Diseases;Play;Positioning Attribute;presynaptic;Presynaptic Terminals;Process;Proteomics;receptor;Resolution;Role;segregation;Sensory;Signal Transduction;Signaling Molecule;Smell Perception;spatiotemporal;Specificity;Stains;Stereotyping;Synapses;Testing;Tissue-Specific Gene Expression;tool;transcription factor;transcriptome;transmission process;Work

PROJECT_TITLE: Assembly of the Central Olfactory Networks in Drosophila

STUDY_SECTION: NDPR

STUDY_SECTION_NAME: Neurodifferentiation, Plasticity, Regeneration and Rhythmicity Study Section[NDPR]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Digestive Diseases;Emerging Infectious Diseases;Immunization;Infectious Diseases;Microbiome;Prevention;Vaccine Related

PI_NAMEs: KELLY, BRENDAN JOSEPH (contact)

PROJECT_TERMS: Academic Medical Centers;adaptive immune response;Adult;Affect;Age;age group;Animal Model;Antigens;biobank;Biological Assay;Biological Specimen database;Blood specimen;Childhood;Clinical;Clinical Data;clinical database;clinically relevant;Clostridioides difficile vaccine;Clostridium difficile;cohort;Colitis;Collaborations;Collection;Communities;comorbidity;Data;Development;Diagnosis;Disease;Ecology;Elderly;Enrollment;Ensure;fecal transplantation;Feces;Genomics;Goals;gut microbiota;Health system;Healthcare;Human;human subject;Hypotension;Ileus;Immune;Immune response;Immunologics;Immunology;In Vitro;Incidence;Individual;Infection;Infection prevention;Infrastructure;innovation;Lead;Longitudinal cohort;Megacolon;Metadata;Microbe;microbial;microorganism interaction;Morbidity - disease rate;mortality;novel;novel vaccines;older patient;Operative Surgical Procedures;Outcome;participant enrollment;patient population;Pediatric cohort;Pediatric Hospitals;Pennsylvania;Philadelphia;Play;Population;Population Heterogeneity;Predictive Factor;prevent;programs;Public Health;Recurrence;Recurrent disease;recurrent infection;Research Project Grants;Risk;Risk Factors;risk mitigation;RNA vaccine;Role;sample collection;Sampling;Severities;Severity of illness;Shock;Specimen;Specimen Handling;stool sample;success;Symptoms;Testing;Time;Universities;Vaccination;vaccination strategy;Vaccine Antigen;vaccine development;Vaccines;Validation;Work

PROJECT_TITLE: Core C. Clinical Core/Human subjects


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: SCOTTSDALE

ORG_NAME: MAYO CLINIC ARIZONA

ORG_STATE: AZ

PHR: Project Narrative Glioblastoma (GBM) is among the most heterogeneous, treatment resistant, and lethal of all human cancers. Despite this heterogeneity, the underlying commonality of GBM is brain invasion, tumor recurrence, and the inherent difficulty in targeting therapeutic agents to brain-invading cancer cells. The central goal of this project is to define the STAT5/OLIG2 signaling axis and its role in promoting GBM invasion and therapeutic resistance.

PI_NAMEs: MEHTA, SHWETAL ;TRAN, NHAN L (contact)

PROGRAM_OFFICER_NAME: FORRY, SUZANNE L

PROJECT_TERMS: Affect;Animals;Brain;cancer cell;Cell Line;Cell model;Cells;Clinical;clinically significant;combinatorial;Complex;Data;dimer;EGFR gene;EGFR Gene Amplification;Epidermal Growth Factor Receptor;epidermal growth factor receptor VIII;Exhibits;Extracellular Domain;Gene Amplification;Genes;Genetic;Genetic Heterogeneity;genetic manipulation;genetic resistance;Glioblastoma;Glioma;Goals;Heterogeneity;Hot Spot;Human;Immunocompetent;in vivo Model;Infiltration;Invaded;JAK1 gene;knock-down;Malignant Neoplasms;Mediating;Modeling;Molecular;mouse model;mutant;Mutation;Oncogenic;patient derived xenograft model;Patients;Phosphorylation;Point Mutation;Property;Protein Isoforms;Receptor Protein-Tyrosine Kinases;Recurrence;Recurrent tumor;Regimen;Regulation;Resistance;Resistance profile;response;Role;Signal Pathway;Signal Transduction;Specimen;Stat5 protein;stem cell exhaustion;stem cell model;stem cell self renewal;stem cells;stemness;success;targeted treatment;temozolomide;Testing;Therapeutic Agents;Therapeutic Intervention;therapeutic target;therapy resistant;transcription factor;Treatment Efficacy;tumor;tumor progression;upstream kinase;Variant

PROJECT_TITLE: STAT5/OLIG2 regulation of GBM therapeutic resistance and recurrence - Resubmit 3.22

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 2 Study Section[MCT2]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Clinical Research;Emerging Infectious Diseases;Immunization;Infectious Diseases;Orphan Drug;Pediatric;Prevention;Rare Diseases;Vaccine Related

ORG_CITY: LA JOLLA

ORG_NAME: LA JOLLA INSTITUTE FOR IMMUNOLOGY

PHR: Narrative This project will develop computational models of the immune responses triggered by B. pertussis booster vaccination. Better understanding of immune responses against B. pertussis will help elucidate what factors might be involved in the recent increase in cases of whooping cough, which is caused by B. pertussis infections. Moreover, establishing such computational models will help understand vaccine-induced immunity in general, and can help in the development and evaluation of new vaccines.

PI_NAMEs: PETERS, BJOERN  (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Address;Adult;Age;age group;Antibodies;Antigen-Antibody Complex;antigen-specific T cells;Antigens;B-Lymphocytes;Bacteria;Biological Assay;booster vaccine;Bordetella pertussis;Case Study;CCL3 gene;Cell Communication;Cell surface;cell type;Cells;Child;Code;cohort;Communities;Computer Models;Country;Coupled;Data;Demographic Impact;Development;Educational workshop;Eligibility Determination;Epidemiology;Evaluation;Event;Feedback;Fine needle aspiration biopsy;Frequencies;Gene Expression;Gene Expression Profile;Generations;Grant;IgG4;Immune;Immune response;Immune system;Immunity;improved;Individual;individual response;infancy;Infant;Infection;lymph nodes;Measurement;Measures;model building;Modeling;Morbidity - disease rate;novel vaccines;Outcome;outreach;peripheral blood;Peripheral Blood Mononuclear Cell;Pertussis;Pertussis Vaccine;Phenotype;Plasma;predictive modeling;Process;Protocols documentation;Proxy;Publications;recruit;Reporting;Research Personnel;response;Sampling;Secondary Immunization;sex;side effect;single-cell RNA sequencing;Specificity;Stains;Structure of germinal center of lymph node;success;T-Lymphocyte;Teaching Materials;Teenagers;Testing;Time;transcriptome sequencing;United States National Institutes of Health;Vaccination;vaccination outcome;vaccine immunogenicity;Vaccine Research;vaccine response;vaccine-induced immunity;Vaccines;web platform;web site

PROJECT_TITLE: Developing computational models to predict the immune response to B. pertussis booster vaccination


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Digestive Diseases;Emerging Infectious Diseases;Immunization;Infectious Diseases;Nanotechnology;Prevention;Vaccine Related

PROJECT_TERMS: Adhesions;Adjuvant;Alginates;Animal Model;Antibiotics;Antibodies;Antigens;Artificial nanoparticles;Bacterial Proteins;Cell Wall;Cells;Cessation of life;Charge;Chemistry;Chitosan;Clinical;clinically relevant;Clostridioides difficile vaccine;Clostridium difficile;Cohort Studies;Collaborations;cytokine;Data;design;Disease;Economic Burden;Elderly;Encapsulated;Engineering;Epithelial Cells;experience;Exposure to;Ferritin;Filament;Formulation;Gastrointestinal Diseases;Genes;Genomics;Gut Mucosa;Homing;Human;Hydrogels;IL17 gene;Immune;Immune Evasion;Immune response;Immune Targeting;immunogenicity;Immunoglobulin A;Immunology;Immunomodulators;immunoregulation;improved;improved outcome;Individual;Infection;inhibitor;innovation;insight;integrin alpha4beta7;interleukin-22;interleukin-23;Interleukin-6;Intestinal Mucosa;Intestines;Intramuscular;Knowledge;Laboratories;Libraries;Life Cycle Stages;Ligands;lipid nanoparticle;Lipids;Maleimides;Mediating;Membrane Proteins;Messenger RNA;microbiota;Microspheres;Morbidity - disease rate;mortality;mRNA delivery;mRNA lipid nano particle vaccine;mucosal addressin cell adhesion molecule-1;Mucosal Immune Responses;Mucosal Immunity;mucosal vaccination;Mucous Membrane;multidisciplinary;multiple omics;Mus;nanoparticle;novel;novel therapeutics;novel vaccines;Nucleosides;Oral;Organ;pathogen;Pediatric Hospitals;Penetration;Philadelphia;prevent;Primary Infection;primary outcome;Production;Property;prophylactic;Proteins;rational design;Recurrence;recurrent infection;Reproduction spores;Resources;response;RNA vaccine;Science;secondary infection;Severity of illness;Stomach;success;Sulfhydryl Compounds;Surface;Testing;Therapeutic;Time;Toxin;Transforming Growth Factor beta;Tropism;vaccine development;vaccine efficacy;vaccine platform;vaccine response;vaccine trial;Vaccines;Work

PROJECT_TITLE: Project 1: Neutralizing and decolonizing Clostridioides difficile using mRNA vaccines


ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PROJECT NARRATIVE The objective of this proposal is to determine how host characteristics impact the localization and abundance of bacterial and host analytes in tissue abscesses during invasive Staphylococcus aureus infection. The proposed studies will deploy cutting-edge imaging tools and spatially resolved proteomics to determine how tissue niche, innate immune responses, and host comorbidities alter bacterial physiology and molecular abscess architecture in situ. This work has the potential to identify new bacterial factors that facilitate S. aureus infection, and to elucidate how host biology alters the expression of antimicrobial and vaccine targets.

PI_NAMEs: CASSAT, JAMES E (contact);SKAAR, ERIC P;SPRAGGINS, JEFFREY M

PROGRAM_OFFICER_NAME: HUNTLEY, CLAYTON C

PROJECT_TERMS: 3-Dimensional;Abscess;Address;Animals;Anti-Bacterial Agents;antimicrobial;Appearance;Architecture;Attention;Bacteria;Bacterial Infections;Bacterial Physiology;Bacterial Proteins;Binding;Biology;Body System;cell type;Cells;Characteristics;comorbidity;Complex;Cues;Data;Detection;Development;Diabetes Mellitus;Disease;Effector Cell;Evolution;experimental study;Fluorescence Microscopy;Fluorescent in Situ Hybridization;Genus staphylococcus;Heterogeneity;Histologic;Histology;human pathogen;Hyperglycemia;Image;Imaging Device;imaging platform;Immune;Immune response;Immunohistochemistry;In Situ;in vivo;Individual;Infection;Inflammatory;Innate Immune Response;innovation;Integration Host Factors;Knowledge;laser capture microdissection;Lesion;Link;Macrophage;Maintenance;mass spectrometric imaging;Mass Spectrum Analysis;Medical;Methods;Microbe;microbial;microbial host;Modeling;Molecular;molecular imaging;mouse model;Murine Tissue Type;Myelosuppression;neutrophil;novel;novel therapeutics;Organ;Osteomyelitis;Outcome;pathogen;Pathogenesis;Pathology;Patients;Peptides;Physiology;Population;Predisposition;preservation;Proteomics;Publishing;Reagent;response;Role;Shapes;Space Perception;Spatial Distribution;Staphylococcal Infections;Staphylococcus aureus;Staphylococcus aureus infection;Techniques;Technology;Testing;Therapeutic;therapeutic candidate;Therapeutic Intervention;Time;Tissue imaging;tissue processing;Tissue Sample;Tissues;transcriptome sequencing;translational medicine;Translational Research;Vaccines;Work

PROJECT_TITLE: Defining the impact of host factors on the molecular architecture and bacterial physiology of Staphylococcus aureus abscesses

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDM-T(02)M]


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Cannabidiol Research;Cannabinoid Research;Epilepsy;Genetics;Intellectual and Developmental Disabilities (IDD);Neurodegenerative;Neurosciences;Pediatric;Rare Diseases;Therapeutic Cannabinoid Research

ORG_CITY: BOSTON

ORG_DEPT: PHARMACOLOGY

ORG_NAME: NORTHEASTERN UNIVERSITY

ORG_STATE: MA

PHR: PROJECT NARRATIVE Dravet Syndrome (DS) causes frequent and prolonged seizures in children, multiple health problems and sudden death. The cause is the loss of function of a Na+ ion channel protein expressed in inhibitory interneurons. We test whether activators of an associated K+ channel can correct for the Na+ channel defect. OMB No. 0925-0001/0002 (Rev. 03/2020 Approved Through 02/28/2023) Page Continuation Format Page

PI_NAMEs: LOGOTHETIS, DIOMEDES E. (contact)

PROGRAM_OFFICER_NAME: UMANAH, GEORGE KWABENA ESSIEN

PROJECT_TERMS: 2 year old;Address;Affect;Age Months;Agonist;Animal Model;Animals;anti-epileptic agents;Ataxia;Brain;Cannabidiol;Cardiac;Cause of Death;Cells;Child;Classification;CNR1 gene;Compensation;Computer Models;Coupled;Defect;density;Developmental Delay Disorders;dimer;Disease;dosage;dravet syndrome;drug discovery;Electroencephalography;Ensure;Epidiolex;Epilepsy;epileptiform;Excision;Experimental Designs;experimental study;FDA approved;Febrile Convulsions;Fenfluramine;Frequencies;Future;G-Protein-Coupled Receptors;gamma-Aminobutyric Acid;Genes;Genetic;GIRK1 subunit, G protein-coupled inwardly-rectifying potassium channel;GTP-Binding Proteins;Health;Heterozygote;Hippocampus;HTR2A gene;Hyperthermia;Impairment;Infant;Interneurons;inward rectifier potassium channel;Ion Channel;Ion Channel Protein;ketogenic diet;Knock-out;Knowledge;Life;loss of function;loss of function mutation;Mediating;Membrane;Membrane Potentials;Modeling;Molecular;Monitor;mouse model;Mus;Muscle hypotonia;Mutation;Nerve;Nervous System Disorder;neuronal circuitry;Neurons;Neurotransmitters;Patients;Pattern;Pharmaceutical Preparations;pharmacologic;Phenotype;Phosphatidylinositols;Plants;Population;Potassium;Potassium Channel;Predisposition;Prefrontal Cortex;prevent;Proteins;Pyramidal Cells;receptor;Recurrence;Resort;Rest;Rodent Model;SCN1A protein;Seizures;side effect;Signal Transduction;Sleep;Sleep disturbances;Slice;small molecule;Speech;Sudden Death;sudden unexpected death in epilepsy;Synapses;synergism;Temperature;Testing;two photon microscopy;two-photon;voltage;voltage gated channel;Work

PROJECT_TITLE: Dravet Syndrome Anti-Epileptic Control by Targeting GIRK Channels

STUDY_SECTION: BBM

STUDY_SECTION_NAME: Biochemistry and Biophysics of Membranes Study Section[BBM]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Digestive Diseases;Emerging Infectious Diseases;Genetics;Immunization;Infectious Diseases;Microbiome;Prevention;Vaccine Related

PI_NAMEs: ZACKULAR, JOSEPH PAUL (contact)

PROJECT_TERMS: Adult;Age;Anatomy;Antibiotics;Antigen Targeting;Antigenic Variation;Antigens;bioinformatics pipeline;Biological Response Modifier Therapy;Cell surface;Cells;Cessation of life;Childhood;Clinical;clinically relevant;Clostridioides difficile vaccine;Clostridium difficile;cohort;Colitis;Collaborations;combat;Combined Modality Therapy;Communities;Complex;design;Development;Diarrhea;Disease;Ecology;Ecosystem;Exposure to;fecal transplantation;fitness;Future;Gastrointestinal Diseases;Gastrointestinal tract structure;gene conservation;Genes;Genetic;Genetic Transcription;Genome;Genomics;Germ-Free;gut colonization;Healthcare;Hospitals;Immune response;Immunity;Infection;innovation;insight;Investigation;Laboratories;Libraries;Life Cycle Stages;Maps;mass spectrometric imaging;Mediating;Messenger RNA;Metabolic;Metalloproteases;microbial;microbial community;microbial composition;microbiota;mouse model;Mutagenesis;next generation;novel;novel therapeutic intervention;novel vaccines;Nutrient;Nutritional Requirements;Nutritional Study;Outcome;pathogen;Patients;Phase;Phenotype;Play;Population;prevent;Prevention;Primary Infection;Primary Prevention;Proteins;Proteome;Proteomics;Public Health;rational design;recurrence prevention;recurrent infection;Reporter;Reproduction spores;RNA vaccination;RNA vaccine;Role;Severities;success;Surface;System;targeted treatment;Therapeutic;Toxin;transcriptomics;transposon sequencing;uptake;Vaccination;Vaccine Antigen;vaccine development;vaccine efficacy;vaccine strategy;Vaccines;Validation;whole genome;Work

PROJECT_TITLE: Project 2: Leveraging microbial ecology to define novel Clostridioides difficile mRNA vaccine targets


ADMINISTERING_IC: DA

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Conditions Affecting the Embryonic and Fetal Periods;Contraception/Reproduction;Drug Abuse (NIDA only);Fetal Alcohol Spectrum Disorders (FASD);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Intellectual and Developmental Disabilities (IDD);Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Social Determinants of Health;Substance Misuse;Women's Health Research

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: SAINT LOUIS UNIVERSITY

PHR: PROJECT NARRATIVE Incarcerated women with substance use disorders (SUD) are at high risk for unintended pregnancy as well as numerous adverse outcomes for their newborn. An efficacious preventive motivational interviewing intervention delivered during the preconception period can reduce the risk of substance exposed pregnancies by promoting continued drug abstinence and reducing risky sexual behaviors in a high risk population. The innovative approach to address the devastating effects of SUD experienced by women and their children being tested in this study will have a sustained impact on the health of the families and communities impacted by illicit substance use, including the over 2 million children touched by the national opioid crisis.

PI_NAMEs: BELLO KOTTENSTETTE, JENNIFER  (contact)

PROGRAM_OFFICER_NAME: HIGHSMITH, KEISHER S

PROJECT_TERMS: addiction;Address;adverse birth outcomes;adverse outcome;Affect;Age;alcohol consequences;alcohol exposure;alcohol intervention;alcohol risk;alcohol risk reduction;alcohol use disorder;Alcohols;American;Awareness;Behavior Therapy;Behavioral Model;Birth;birth control;brief advice;Cessation of life;Child;Child Custody;clinical practice;clinically significant;Community Health;comparison control;Conceptions;condoms;contraceptive efficacy;Contraceptive methods;Contraceptive Usage;County;Coupled;court;Criminal Justice;Diagnosis;drug abstinence;drug relapse;Drug usage;education planning;efficacy outcomes;efficacy testing;Elements;Ensure;Environment;evidence base;experience;Exposure to;Family;Family health status;Family Practice;Fetal Alcohol Exposure;Fetal Growth Retardation;Focus Groups;Future;Goals;group intervention;Health;health equity;high risk;high risk drinking;high risk population;high risk sexual behavior;High Risk Woman;illicit drug use;Illicit Drugs;Imprisonment;improved;in utero;Incidence;innovation;interest;Intervention;Jail;Justice;Legal;Life;life span;Live Birth;Manuals;Medicine;Mental Depression;Mission;Mothers;Motivation;motivational enhancement therapy;National Institute of Drug Abuse;Neonatal Abstinence Syndrome;Newborn Infant;opioid epidemic;Outcome;Palpable;Parents;Patients;Pharmaceutical Preparations;pilot test;Population;post pregnancy;Pregnancy;pregnant;premature;Prevalence;Preventive;Public Health;Recommendation;Recording of previous events;recruit;reproductive;Reproductive Health;Research;Research Activity;Research Assistant;Research Personnel;Risk;Risk Reduction;sex;sexual encounter;Sexually Transmitted Diseases;Societies;Statistical Methods;substance use;Substance Use Disorder;Surveys;System;Target Populations;Testing;therapy design;therapy development;Time;Tobacco Use Cessation;Tobacco Use Disorder;Touch sensation;Training;treatment program;treatment strategy;unintended pregnancy;United States National Institutes of Health;Woman;Work

PROJECT_TITLE: A Preconception Health Intervention to Reduce Substance Exposed Pregnancies among Incarcerated Women

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


NIH_SPENDING_CATS: Cancer;Immunotherapy

ORG_NAME: UNIVERSITY OF CHICAGO

PHR: Relevance: IFN-γ-producing lymphoid cells play an important role in anti-virus, anti-bacteria and anti-cancer immune responses and therefore it is imperative that we understand the mechanisms that control their expansion and effector function. This project is focused evaluating the role of the transcription factor Helios in NK cell effector maturation and function. The results of these experiments will impact our understanding of NK cell biology and may impact our ability to manipulate the expansion and differentiation of these cells.

PI_NAMEs: KEE, BARBARA L. (contact)

PROGRAM_OFFICER_NAME: JOFFE, AARON MICHAEL

PROJECT_TERMS: Acute Myelocytic Leukemia;adaptive immune response;anti-cancer;Bacteria;Biological Assay;Biological Models;CD8-Positive T-Lymphocytes;Cell Count;Cell Differentiation process;Cell Maturation;Cell Physiology;Cells;Cellular biology;chemokine;chimeric antigen receptor;Chronic;crosslink;cytokine;cytotoxic;Data;Defect;Dendritic Cells;Development;Disease;Effector Cell;Engineering;experimental study;Family;Flow Cytometry;Foundations;functional loss;Future;Generations;Genes;Goals;graft vs leukemia effect;Grant;Half-Life;Immune response;Immunotherapeutic agent;In Vitro;in vivo;in vivo Model;Inflammatory;Interferon Type II;Interleukin-15;ITGAM gene;Laboratories;leukemia;leukemic stem cell;Lymphoid Cell;Maintenance;Malignant - descriptor;Melanoma;member;Murid herpesvirus 1;Mus;Mutate;Natural Killer Cells;Neoplasm Metastasis;neoplastic cell;pathogen;Phenotype;Play;premature;prevent;programs;receptor;Receptor Cell;receptor expression;receptor function;recruit;Regulatory T-Lymphocyte;Research;response;Role;self-renewal;stem cell self renewal;Testing;Therapeutic;Therapeutic Intervention;transcription factor;transcription regulatory network;transgene expression;tumor;Undifferentiated;Viral;Virus;Wild Type Mouse

PROJECT_TITLE: Investigating Helios as a regulator of natural killer cell effector maturation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIA-C(02)]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences;Pediatric

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative  The OSU College of Optometry T35 program has trained 164 students in 19 years. These students published 195 scientific abstracts and 59 peer-reviewed manuscripts, 82 received MS degrees, five received PhD degrees, four are currently in PhD programs, and four have participated in NIH awards. Support of the program will continue to develop optometrists who conduct independent vision research.

PI_NAMEs: ANDERSON, HEATHER ANNE (contact)

PROGRAM_OFFICER_NAME: CLAYTON, EDWIN C

PROJECT_TERMS: adaptive optics;Area;Biomechanics;Biomedical Engineering;career;Cataract;Clinical;cohort;college;Color Perception;Doctor of Philosophy;Embryonic Development;Enrollment;Eye;Faculty;Funding;Future;Goals;Grant;Health Professional;Journals;Laboratories;Literature;Master of Science;member;Mentors;Neurosciences;Ohio;Ophthalmology;Optometry;Participant;Pediatrics;Peer Review;Positioning Attribute;professional students;programs;Publications;Refractive Errors;Research;Research Ethics;Research Personnel;Research Training;Retinal Detachment;Schools;Scientist;Students;Training;Training Programs;undergraduate student;Universities;Vision;vision rehabilitation;Vision research;vision science

PROJECT_TITLE: Short Term Training: Students in Health Professional Schools


PI_NAMEs: ABT, MICHAEL C. (contact)

PROJECT_TERMS: Acute;adaptive immune response;adaptive immunity;Age;age related;Animal Model;Animals;Antibodies;Antibody Response;Automobile Driving;B-Lymphocytes;Binding;CD4 Positive T Lymphocytes;Cell Differentiation process;Cell Surface Proteins;Cells;Characteristics;Childhood;Chronic Phase;Clinical;Clostridioides difficile vaccine;Clostridium difficile;Data;Defect;Disease;DNA;draining lymph node;Elderly;Engineering;experience;fecal transplantation;Feces;Feedback;Filtration;Flow Cytometry;Generations;Genetic Transcription;Goals;Helper-Inducer T-Lymphocyte;high dimensionality;high risk;high risk population;Human;Immune;Immune Evasion;Immune response;Immune system;Immune Targeting;Immunity;Immunocompetent;Immunodeficient Mouse;Immunologic Memory;Immunoprecipitation;Impairment;In Situ;In Vitro;in vivo;Infection;Intestinal Mucosa;Intestines;Large Intestine;Mass Spectrum Analysis;Memory B-Lymphocyte;Messenger RNA;metagenomic sequencing;microbial;Microscopy;Mucosal Immunity;Mucous body substance;Mus;Natural Immunity;old mice;outcome disparities;pathogen;Pathway interactions;patient population;Patients;Physiology;Population;pressure;prevent;primary endpoint;Primary Infection;Rag1 Mouse;Recurrence;recurrent infection;Reporting;Resolution;response;Risk;RNA vaccine;Sampling;Serum;Severity of illness;Shapes;Sterility;success;System;Toxin;transcriptome;transcriptome sequencing;transmission process;unvaccinated;Vaccinated;vaccine candidate;Vaccine Clinical Trial;Vaccine Design;vaccine development;vaccine response;vaccine trial;vaccine-induced immunity;Vaccines;Virulence Factors;Visualization;young adult

PROJECT_TITLE: Project 3: Defining adaptive immune interactions that shape Clostridioides difficile infection


NIH_SPENDING_CATS: Brain Disorders;Cerebrovascular;Clinical Research;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Neurosciences;Patient Safety;Social Determinants of Health;Stroke

ORG_CITY: CINCINNATI

ORG_NAME: UNIVERSITY OF CINCINNATI

PHR: Project Narrative Subdural hematomas are a form of bleeding in the head that are becoming more common; they often require surgery and can be fatal. We want to understand how this disease affects people weeks and months after the initial event. By studying longer term outcomes, we hope to identify factors that could help future patients recover from this disease.

PI_NAMEs: ROBINSON, DAVID  (contact)

PROGRAM_OFFICER_NAME: BENSON, RICHARD T

PROJECT_TERMS: Acute;acute care;Address;adverse outcome;Affect;Attention;Benefits and Risks;Big Data;Blood Vessels;Case Fatality Rates;Case Series;Cephalic;Cerebral hemisphere hemorrhage;Cessation of life;Chronic;Clinical;Clinical Data;clinical database;Computerized Medical Record;cost;County;Craniocerebral Trauma;Data Science;Death Rate;Development;Diagnosis;disabled;Disease;Disparity;Epidemiologist;Epidemiology;Epilepsy;Ethnic Origin;Event;Fibrinolytic Agents;follow-up;Future;Goals;Head;health care availability;health care disparity;Hematoma;Hemorrhage;high risk;Hospital Mortality;hospital readmission;Hospitalization;Hospitals;improved;Incidence;Incidence Study;indexing;Informatics;Infrastructure;Insurance;Insurance Coverage;International Classification of Disease Codes;Intracranial Hemorrhages;Ischemia;Ischemic Stroke;Kentucky;large datasets;Machine Learning;machine learning algorithm;Measures;Medicaid;Mentorship;Modeling;Modernization;Myocardial Infarction;neurosurgery;novel;Operative Surgical Procedures;Outcome;Outcome Measure;outcome prediction;Patients;Persons;Pharmaceutical Preparations;Physicians;Population;Population Study;predictive modeling;Public Health;Race;Randomized, Controlled Trials;readmission rates;Recurrence;Research;Research Personnel;Resources;Risk;Scientist;Seizures;skills;social health determinants;Status Epilepticus;Stroke;stroke incidence;stroke outcome;Subdural Hematoma;Survivors;Techniques;thrombotic;Time;Trauma;United States;Work

PROJECT_TITLE: The Subdural Hematoma Outcomes in a Population (SD HOP) Study


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Cost Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Physical Activity;Prevention;Social Determinants of Health

ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: PROJECT NARRATIVE School physical education (PE) is one of the most valuable tools for increasing physical activity and fitness among youth of all backgrounds; however, compliance with existing PE laws is low (and differential by school race/ethnic and family-income composition, contributing to health disparities), and best practices for increasing compliance remain unknown. The proposed study will examine the impact of the New York City Department of Education’s multi-level school physical education (PE) intervention on PE law compliance and student cardiorespiratory fitness, as well as its cost-effectiveness for increasing student physical activity. In addition, one component of New York’s intervention – a PE audit and feedback tool – will be piloted in Oakland, CA schools to determine the effectiveness, adaptability, and scalability of this potential approach to increasing PE law compliance.

PI_NAMEs: THOMPSON, HANNAH R (contact)

PROGRAM_OFFICER_NAME: DONZE, LAURIE FRIEDMAN

PROJECT_TERMS: Accountability;Address;Adopted;Adoption;Award;California;cardiorespiratory fitness;cardiovascular disorder risk;Cardiovascular system;career;Chronic Disease;collaborative environment;community based participatory research;Complex;Coronary heart disease;cost;cost effective;cost effectiveness;Cost Effectiveness Analysis;Country;Data;design;Development;Diffusion of Innovation;Disparity;Education;education research;Educational Intervention;effectiveness evaluation;elementary school;Environment;Epidemiologic Methods;Ethnic Origin;Evaluation;experience;Family;Feedback;fifth grade;fitness;Funding;Future;Goals;Health;health disparity;health inequalities;implementation science;improved;Income;Institution;Intervention;K-Series Research Career Programs;Knowledge;Laws;Maintenance;Measures;meetings;Mentored Research Scientist Development Award;Mentors;Methods;moderate-to-vigorous physical activity;National Heart, Lung, and Blood Institute;New York;New York City;novel;novel strategies;Nutrition Policy;Outcome;Physical activity;Physical Education;Physical Fitness;physical inactivity;physical state;pilot test;Policies;Population;population health;Productivity;Public Health Schools;Race;Randomized;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Reduce health disparities;Research;Research Activity;Research Personnel;Resources;Risk;school district;Schools;skills;Solid;Students;System;Testing;theories;Time;tool;Training;United States National Institutes of Health;Work;Youth

PROJECT_TITLE: Increasing compliance with physical education laws to reduce health inequities

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(OA)]


ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: Project Narrative Interstitial fibrosis is a chronic and progressive process affecting kidneys during chronic kidney disease (CKD) progression, regardless of cause. Currently, biopsy remains the gold standard for assessing kidney fibrosis, but complications and limitations exist. This proposal is designed to develop an innovative nanoprobe to noninvasively assess kidney fibrosis in the early-stage technology development.

PI_NAMEs: XU, LEYUAN  (contact)

PROGRAM_OFFICER_NAME: RANKIN, TRACY L

PROJECT_TERMS: Acute Renal Failure with Renal Papillary Necrosis;Affect;Allografting;Apoptotic;Architecture;Atherosclerosis;Atrophic;Attenuated;Biodistribution;biomaterial compatibility;biomedical imaging;Biopsy;Cd68;Cells;Chemotactic Factors;CHI3L1 gene;Chronic;Chronic Kidney Failure;Complex;Contrast Media;Data;Dendrimers;Deposition;design;Detection;Diagnosis;Diagnostic;Disease Progression;Drug Kinetics;Engineering;Evaluation;Extracellular Matrix;Failure;Fibrosis;Fluorescein;Fluorescence;follow-up;Genes;Genetic Transcription;Heterogeneity;Histologic;Histology;Human;Image;imaging modality;imaging probe;Immune;In Vitro;in vivo;Inflammatory;Injury;innovation;interstitial;Investigation;Ischemia;Kidney;Kidney Diseases;Kidney Failure;kidney fibrosis;Kinetics;Knock-out;Label;Ligands;Macrophage;Magnetic Resonance Imaging;Malignant Neoplasms;Mannose;mannose receptor;mathematical model;Modeling;molecular imaging;mouse model;nanoparticle;nanoprobe;nanoscale;non-invasive imaging;noninvasive diagnosis;novel;optical imaging;Patients;Phenotype;Physiological;Play;Preclinical Testing;Premature Mortality;Prevalence;Process;Prognosis;prognostication;Proteins;receptor;Renal function;repaired;Reperfusion Injury;Reporting;Role;Sensitivity and Specificity;Severities;side effect;Specificity;Techniques;technology development;Testing;tissue repair;tool;Tubular formation;ultrasound;uptake;Vascular blood supply;years of life lost;zeta potential

PROJECT_TITLE: Developing imaging nanoprobes to advance prognosis of kidney fibrosis


NIH_SPENDING_CATS: Aging;Bioengineering;Biomedical Imaging;Clinical Research;Eye Disease and Disorders of Vision;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Prevention;Telehealth

ORG_DEPT: SURGERY

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE Glaucoma is the leading cause of irreversible blindness in the world. However, since the disease can be asymptomatic until later stages, many patients with glaucoma will not know they have glaucoma until they suffer substantial and irreversible visual field loss. This study seeks to refine and validate a deep learning algorithm for early diagnosis of glaucoma on optic disc photographs and subsequently test it in a pilot teleophthalmology program.

PI_NAMEs: THOMPSON, ATALIE C (contact)

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: Address;Adult;Advisory Committees;Agreement;algorithm training;Algorithms;artificial intelligence algorithm;Assisted Living Facilities;Binding;Biomedical Engineering;Biometry;Blindness;career;carina;Clinical;Clinical Research;cohort;Consumption;cost;cost effective;Data;deep learning;deep learning algorithm;deep neural network;demographics;Dependence;Detection;Development;Diabetic Retinopathy;Diagnosis;diagnostic tool;Discrimination;Disease;Early Diagnosis;Effectiveness;Environment;Epidemiology;Evaluation;experience;Eye;eye center;Eye diseases;Fellowship;Frequencies;Fundus;Fundus photography;Glaucoma;Goals;Grant;health care disparity;high risk;high risk population;Human;Image;Imaging technology;Improve Access;improved;innovation;Institution;interest;Label;learning network;Machine Learning;Manuals;Masks;Master of Science;Measurement;Medical;Medicine;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Nature;neural network;novel;novel diagnostics;ophthalmic examination;Optic Disk;Optical Coherence Tomography;optical disc;Output;Patients;Perimetry;population based;primary care clinic;programs;prospective;Public Health;public health intervention;Reference Standards;Reproducibility;Research;Research Priority;Resource-limited setting;Resources;responsible research conduct;retinal nerve fiber layer;Scientist;screening;Screening procedure;Sensitivity and Specificity;Severity of illness;Specialist;Suspect Glaucomas;Technology;teleophthalmology;Testing;Thick;Time;tonometry;tool;Training;Validation;Visual Fields;Visual impairment;Width;Work

PROJECT_TITLE: Deep learning to quantify glaucomatous damage on fundus photographs for teleophthalmology


NIH_SPENDING_CATS: Assistive Technology;Behavioral and Social Science;Bioengineering;Brain Disorders;Depression;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Neurosciences;Rehabilitation

ORG_NAME: DUKE UNIVERSITY

PHR: Project Narrative Non-invasive brain stimulation with electrical currents or magnetic fields applied to the head is a major approach for treating brain disorders. However, these approaches are sometimes ineffective or cause side effects for some patients. This project will develop software that estimates the effect of non-invasive brain stimulation on brain cells (neurons), and this tool can be used to individualize the procedure to improve clinical outcomes.

PI_NAMEs: GRILL, WARREN M.;PETERCHEV, ANGEL V (contact)

PROGRAM_OFFICER_NAME: TILGHMAN, JESSICA IRENE

PROJECT_TERMS: Anatomy;Anxiety;anxiety treatment;Axon;Brain;brain cell;Brain Diseases;Brain region;Catatonia;Cephalic;Cerebrum;Characteristics;Classification;Clinical;clinical efficacy;Clinical Trials;Cognitive;Computer software;computerized tools;computing resources;Data;Deep Brain Stimulation;Dendrites;Devices;Dose;dosimetry;electric field;Electric Stimulation;Electric Stimulation Therapy;Electroconvulsive Therapy;Elements;experimental study;Fiber;Goals;Head;improved;Individual;Individual Differences;individual patient;Intervention;Libraries;Link;Machine Learning;magnetic field;Magnetism;Membrane;Mental Depression;Mental Health;Modality;Modeling;Morphology;Motor Cortex;Muscle;neural;neural model;neuronal cell body;Neurons;neuroregulation;noninvasive brain stimulation;Obsessive-Compulsive Disorder;Operative Surgical Procedures;Outcome;Patients;Population;Prefrontal Cortex;Procedures;prospective;Psychiatric therapeutic procedure;Publishing;Research Personnel;Research Subjects;response;Safety;side effect;simulation;simulation software;single episode major depressive disorder;Sleeplessness;smoking addiction;software development;Stimulus;success;therapeutic target;tool;Transcranial magnetic stimulation;user friendly software;Visualization

PROJECT_TITLE: NeuroSimNIBS: Integrated electric field and neuronal response modeling for transcranial electric and magnetic stimulation


NIH_SPENDING_CATS: Atherosclerosis;Brain Disorders;Cardiovascular;Cerebrovascular;Clinical Research;Heart Disease;Heart Disease - Coronary Heart Disease;Neurosciences;Stroke

ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Project Narrative Utilizing platelet-specific and myeloid-specific PKM2 deficient mice as model systems, the proposed studies seek to validate a new mechanistic paradigm to understand how aerobic glycolysis regulates platelet and leukocyte function and whether targeting PKM2, a key regulator of aerobic glycolysis, will inhibit thrombosis and inflammation. In addition, the proposed studies will define the role of PKM2 in the thrombo-inflammatory condition ischemic stroke, a serious health and economic problem, and test whether therapeutic targeting of PKM2 will improve stroke outcomes in pre-clinical stroke models.

PI_NAMEs: CHAUHAN, ANIL KUMAR (contact)

PROGRAM_OFFICER_NAME: WARREN, RONALD Q

PROJECT_TERMS: abciximab;Acute;acute coronary syndrome;aerobic glycolysis;Animal Model;Anti-Inflammatory Agents;Antiplatelet Drugs;Aspirin;bench to bedside;Biological Models;Blood Platelets;Cardiovascular Diseases;Clinical;clinical efficacy;combat;Coronary Arteriosclerosis;Data;dimer;Disease;Economic Burden;Economics;Energy Metabolism;Enzymes;Exhibits;experience;Genetic;Glucose;Glycoproteins;Goals;Guidelines;Health;Hemorrhage;high reward;high risk;Hyperlipidemia;improved;improved outcome;Industry;Inflammation;Inflammatory;inhibitor;innovation;intravital microscopy;Ischemic Stroke;Leukocytes;Macrophage;Malignant Neoplasms;monocyte;mouse model;Mus;mutant;Myelogenous;new therapeutic target;Normal Cell;novel;novel strategies;Oxidative Phosphorylation;Oxygen;Patients;Pharmaceutical Preparations;pharmacologic;Phenotype;pre-clinical;prevent;Productivity;programs;Pyruvate Kinase;Reagent;Research;Resolution;response;Rest;Risk;Role;Scientist;Stroke;stroke model;stroke outcome;stroke therapy;success;Testing;therapeutic target;thromboinflammation;Thrombosis;tool;United States;Update

PROJECT_TITLE: Targeting Pyruvate Kinase M2: A novel strategy to combat thrombo-inflammation


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Services;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: UNIVERSITY

ORG_DEPT: ADMINISTRATION

ORG_NAME: UNIVERSITY OF MISSISSIPPI

ORG_STATE: MS

PHR: PROJECT NARRATIVE  Project SCORE Project SCORE (Student Centered Outcomes Research Experience) will use a youth participatory action research approach to overcome the fact that existing education, prevention, and intervention efforts to improve health outcomes for Mississippi’s youth have been less than successful due to a lack of direct input from affected youth. Project SCORE will bring together underrepresented high school and graduate health sciences students from communities with significant health disparities in a year-long informal public health education program and mentored research experience to develop relevant health behavior and promotion research questions, provide exposure to public health concepts, training in research methods, and facilitate the development of student-conducted research projects mentored by near-peer graduate health sciences students and faculty. Participants will develop improved health and data literacy, increased science engagement and interest in STEM careers, and increased matriculation into STEM college programs.

PI_NAMEs: BARNARD, MARIE  (contact)

PROGRAM_OFFICER_NAME: BECK, LAWRENCE A

PROJECT_TERMS: access disparities;Address;Adolescent;Adopted;Advocate;Affect;after-school program;Area;Attention;Awareness;Bachelor's Degree;Behavior;biobehavior;Birth;career;career awareness;Career Exploration;Chronic Disease;college;Communication;Communities;community based participatory research;community engaged research;community engagement;COVID-19;data literacy;design;Development;Education;Engineering;Equity;Exercise;experience;Exposure to;Faculty;Future;graduate student;Health;Health behavior;health care availability;health disparity;Health education;Health Food;health literacy;Health Promotion;Health Sciences;Health Status;Healthy Eating;high risk sexual behavior;high school;High School Student;higher education;Immersion;improved;Individual;insight;interest;Intervention;intervention program;Knowledge;Leadership;Lived experience;matriculation;Mediation;Mentors;Methods;Mississippi;Modeling;next generation;novel;Occupations;Outcome;Outcomes Research;Participant;Pathway interactions;patient engagement;patient oriented;Patients;peer;peer coaching;Populations at Risk;preventable death;Prevention;programs;protective behavior;Public Health;Public Health Education;public health intervention;Public Health Schools;Published Comment;recruit;Reporting;Research;Research Methodology;Research Project Grants;Research Subjects;Role;Science;Scientist;Seat Belts;skills;social;STEM career;STEM program;student participation;Students;synergism;Time;Tobacco use;Training;Underrepresented Populations;Underrepresented Students;United States;Work;Youth

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(56)R]


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Genetics;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Microbiome;Nutrition;Obesity;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

PHR: PROJECT NARRATIVE Weight loss among overweight/obese individuals is a key component of the primary prevention of cardiovascular disease, but there is marked variability across individuals in response to lifestyle weight loss interventions, some of which could be explained by genetic, gut microbiome, and metabolomic factors. It is critical to improve our understanding of the drivers of weight loss responsiveness as this may offer new insight into causal factors in obesity and may ultimately lead to novel or more personalized prevention or treatment opportunities. In this study, I will capitalize on data collected during an ongoing 1-year lifestyle weight loss intervention trial (R01 DK068001/ PI Catenacci) in order to examine omic pathways (genetics, gut microbiota, and serum metabolites) and obesity-related health measures over the course of the intervention, which will inform an investigation into gut microbiota and metabolites as mediators of the association between genetic obesity risk and obesity-related phenotypes in larger epidemiological cohorts.

PI_NAMEs: STANISLAWSKI, MAGGIE A (contact)

PROGRAM_OFFICER_NAME: COADY, SEAN

PROJECT_TERMS: Address;Adult;Area;Bioinformatics;Biological Assay;Biometry;Blood specimen;Body mass index;Body Weight decreased;Caloric Restriction;cardiometabolism;Cardiovascular Diseases;cardiovascular disorder prevention;cardiovascular disorder risk;career;Cause of Death;Clinical;cohort;Colorado;Complex;Coronary Artery Risk Development in Young Adults Study;Data;Development;diaries;Diet;dietary;Dietary intake;Disease;Environment;Epidemiology;ethnic diversity;Ethnic Origin;follow-up;Foundations;Functional disorder;Genetic;genetic epidemiology;Genetic Risk;genetic variant;Goals;group intervention;gut microbiome;gut microbiota;Health;high risk;Hispanic Community Health Study/Study of Latinos;Human;improved;Individual;individualized prevention;innovation;insight;Institution;Intermittent fasting;Intervention;Intervention Studies;Intervention Trial;Investigation;K-Series Research Career Programs;Life Style;lifestyle intervention;Measures;Mediating;Mediation;Mediator;Medical;Mentors;Mentorship;Metabolic dysfunction;Metabolic syndrome;metabolomics;Metagenomics;Methods;Molecular Epidemiology;multi-ethnic;Multiomic Data;novel;novel strategies;obese person;Obesity;obesity genetics;obesity prevention;obesity risk;obesity treatment;Observational epidemiology;Observational Study;Outcome;Overweight;Participant;Pathway interactions;personalized approach;personalized medicine;Persons;Phenotype;Physical activity;Play;polygenic risk score;Population;predicting response;Prevention;Prevention approach;Primary Prevention;Process;Protons;racial difference;Randomized;Research;Research Personnel;Research Project Grants;Resources;response;Risk Factors;Risk Reduction;Role;Serum;Shotguns;Signal Pathway;Signal Transduction;skills;stool sample;success;symposium;Taxonomy;Training;treatment arm;Universities;waist circumference;weight loss intervention;Work

PROJECT_TITLE: The Contribution of Omic Profiles to Weight Loss and Obesity


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE – OVERALL The goal of the JHU Center for the Advancement of HIV Neurotherapeutics (JHU CAHN) is to drive high-impact science focused on developing novel treatments to reduce the impact of CNS complications in people with HIV. The Center will accomplish this by providing NeuroHIV-focused resources and expertise within JHU and with other HIV Centers including richly phenotyped clinical data, state-of the-art biomarker analyses and informatics, and integrated drug discovery services. The Center will also mentor, train, educate, and provide pilot funds to early stage investigators and those new to NeuroHIV with a focus on underrepresented populations.

PI_NAMEs: CLEMENTS, JANICE E;RUBIN, LEAH HELANE (contact);SLUSHER, BARBARA STAUCH

PROGRAM_OFFICER_NAME: RAO, VASUDEV RAMACHANDRA

PROJECT_TERMS: Address;Advisory Committees;Animals;Arousal and Regulatory Systems;assay development;Award;Biological Markers;biomarker identification;Caregivers;Central Nervous System;Clinic;Clinical;clinical center;Clinical Data;clinical phenotype;Clinical Research;Cognitive;Collaborations;Communication;Communities;community partners;comorbidity;Consultations;cost;Country;Data;Development;drug development;drug discovery;Drug Kinetics;drug metabolism;Education;Electronic Mail;Emerging Technologies;Exhibits;Faculty;Feedback;Fostering;Funding;Goals;Grant;HIV;HIV Infections;Human;Impaired cognition;Individual;Informatics;Infrastructure;innovation;interest;Intervention;investigator training;Joints;Link;Machine Learning;Medical;meetings;Mental Health;Mentors;Mentorship;Methods;Minority Groups;Mission;Modeling;Monitor;mouse model;multidisciplinary;National Institute of Mental Health;Negative Valence;neuroAIDS;neuroimaging;Neurologic;Newsletter;next generation;novel;novel therapeutics;Office of Administrative Management;outreach program;Pathway interactions;Patients;personalized medicine;Persons;Pharmaceutical Chemistry;Pharmacology and Toxicology;Phenotype;Pilot Projects;Positive Valence;pre-clinical;Program Reviews;programs;Research;Research Domain Criteria;Research Personnel;Research Priority;Resources;Science;Scientist;screening;senior faculty;Series;Services;Strategic Planning;symposium;System;Talents;Techniques;Therapeutic;Therapeutic Agents;therapeutic development;therapeutic target;Time;tool;Training;Translating;Translational Research;treatment response;twelfth grade;Underrepresented Minority;Underrepresented Populations;United States National Institutes of Health;virtual;web site;Work


PI_NAMEs: HAUGHEY, NORMAN J (contact)

PROJECT_TERMS: Accountability;Advisory Committees;Annual Reports;Award;Baltimore;base;Biological Markers;Budgets;career;Clinical;Clinical Research;Clinical Trials;Communication;comorbidity;Core Facility;dashboard;Data;Development;Education;Educational workshop;Ensure;Event;Faculty;Faculty Recruitment;Funding;Goals;Grant;Guidelines;HIV;Image;Infrastructure;Institution;interest;Joints;Leadership;Maryland;medical schools;Medicine;meetings;Mentors;Mission;Modification;Monitor;National Institute of Mental Health;neuroAIDS;Neurology;novel;operation;outreach;Persons;Policies;Productivity;programs;Progress Reports;Public Health;Research;Research Activity;Research Personnel;research study;Research Support;Resources;response;Role;Science;Senior Scientist;Series;Services;skills;Source;Structure;symposium;Time;Training;Training and Education;training opportunity;Training Programs;translational approach;United States;Universities;virtual;virtual platform;web site;Work

PROJECT_TITLE: JHU Center for the Advancement of HIV Neurotherapeutics (JHU CAHN) - Admin Core


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Neurodegenerative;Neurosciences

PI_NAMEs: HOKE, AHMET  (contact)

PROJECT_TERMS: Academia;Applications Grants;Area;Award;Behavioral Assay;Biological Assay;career;career development;Cells;Clinical;Collaborations;Communication;Communities;community advisory board;community engagement;community science;Complication;dashboard;Data;deaf;Development;Direct Costs;disability;disparity gap;drug candidate;drug development;Education;Event;Extramural Activities;falls;Feedback;follow-up;Fostering;Funding;Goals;Grant;Hand;hard of hearing;Health;high reward;high risk;HIV;Human;improved;innovation;Institution;International;Investments;Joints;Lead;Leadership;Life Cycle Stages;Link;low socioeconomic status;member;men;Mentors;Mentorship;Minority;minority trainee;Monitor;National Institute of Mental Health;neuroAIDS;Neurovirology;new technology;novel;novel therapeutics;Opportunistic Infections;Persons;Pilot Projects;Process;programs;Publishing;Research;research and development;Research Domain Criteria;Research Personnel;Resources;Retroviridae Infections;Rewards;Rodent Model;science education;Scientific Advances and Accomplishments;Scientist;screening;Series;Societies;Structure;Support Groups;symposium;System;Technology;Testing;Therapeutic;Training;Underrepresented Minority;Underrepresented Populations;United States National Institutes of Health;verbal;Viral;Woman;Work;Workforce Development;Writing

PROJECT_TITLE: JHU Center for the Advancement of HIV Neurotherapeutics (JHU CAHN) - Development Core


NIH_SPENDING_CATS: Clinical Research;Kidney Disease

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: PROJECT NARRATIVE This study will elucidate how disrupted iron homeostasis is related to the function of circulating monocytes, precursors of kidney macrophages, in patients with chronic kidney disease. Kidney macrophages, most of which originate from circulating monocytes, are critically important in progression of kidney fibrosis, the final common mechanism of all individual progressive kidney disorders leading to chronic kidney disease; and at the same time macrophages play critical role in iron metabolism, which is severely altered in chronic kidney disease. By addressing the critical knowledge gap about the connection between iron metabolism and differentiation of circulating monocytes as they invade injured kidney tissue and become macrophages, this project will enhance the capabilities of the primary investigator in attaining his long-term goal of identifying novel actionable drivers of chronic kidney disease progression due to alterations in iron homeostasis, so that they can be therapeutically targeted to improve outcomes in patients with chronic kidney disease.

PI_NAMEs: AKCHURIN, OLEH  (contact)

PROJECT_TERMS: Acceleration;Address;Adult;Affect;American;Anemia;Animal Model;Antioxidants;Award;Behavior;biobank;Cells;Characteristics;chemokine;chemokine receptor;Chemotactic Factors;Chemotaxis;Child;Chronic;Chronic Kidney Failure;Clinical;Collecting Cell;Color;CX3CL1 gene;Data;Dialysis procedure;Disease Progression;End stage renal failure;Etiology;Evaluation;Excretory function;Exhibits;experience;experimental study;Fibrosis;Flow Cytometry;Functional disorder;Funding;Genes;Goals;Homeostasis;Human;human data;improved outcome;Individual;Inflammatory;Injury to Kidney;Invaded;Iron;iron deficiency;iron metabolism;Kidney;Kidney Diseases;Kidney Failure;kidney fibrosis;Kidney Transplantation;Knowledge;Life Cycle Stages;Macrophage;migration;Molecular;monocyte;Mus;Myelogenous;Myeloid Cells;novel;Pathogenicity;Pathologic;Patients;Peripheral;peripheral blood;Peripheral Blood Mononuclear Cell;Persons;Phenotype;Play;Population;preclinical study;Proteins;receptor;Renal function;repository;Research Personnel;response;Role;Serum;systemic inflammatory response;Techniques;Testing;Therapeutic;therapeutic target;Time;Tissues;transcriptomics;Urine;Work

PROJECT_TITLE: Iron homeostasis and monocyte differentiation in patients with chronic kidney disease

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;HIV/AIDS;Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Precision Medicine

PROJECT_TERMS: Anhedonia;Arousal and Regulatory Systems;Bayesian Analysis;Behavior;Biological Assay;Biological Markers;Biological Models;biomarker development;biomarker discovery;biotypes;career development;Charge;Chemicals;Classification;Clinical;Clinical Trials;Cognition;Communication;Communities;Consultations;Coupled;Data;Data Analyses;Databases;Development;Dimensions;Discriminant Analysis;Drug Targeting;effectiveness evaluation;Encyclopedias;experimental group;extracellular vesicles;Faculty;field study;Fright;Genes;Genome;Goals;Grant;HIV;Impaired cognition;Individual;Informatics;Institution;interest;Intervention;Least-Squares Analysis;Lipids;Machine Learning;machine learning algorithm;Mass Spectrum Analysis;Measures;Mentorship;Metabolic;Mission;Modeling;Modification;Molecular Target;molecular targeted therapies;multidimensional data;National Institute of Mental Health;Negative Valence;neuroAIDS;Neurobiology;Outcome Measure;Pathway Analysis;Pathway interactions;personalized medicine;Persons;Pharmaceutical Preparations;pharmacodynamic biomarker;Positive Valence;Pre-Clinical Model;Principal Component Analysis;Proteins;Research;Research Design;Research Domain Criteria;Research Personnel;Resource Informatics;Resources;Sampling;sensorimotor system;Series;Services;Signal Pathway;Site;Sleep;small molecule;social;Social Processes;System;Techniques;Therapeutic;therapeutic development;therapeutic target;tool;Training;training opportunity;virtual;Work

PROJECT_TITLE: JHU Center for the Advancement of HIV Neurotherapeutics (JHU CAHN) - Biomarker Core


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Dental, Oral, and Craniofacial Disease;Emerging Infectious Diseases;Infectious Diseases;Microbiome;Nanotechnology;Prevention;Regenerative Medicine

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE Dental resin composites have been widely used clinically due to their bonding potential to the tooth tissues, good mechanical properties, and lower cost compared to other indirect restorations. While successful, long-term survival of a restoration can be compromised by secondary caries at the tooth-composite margins mainly due to the microleakage of bacteria and their acid by-products. We propose to develop new antibiofilm dental composites that inhibit biofilm accumulation as well as dislodging surface-adhered microbes on restorative materials using enhanced electric potential at the interface generated by oral motion.

PI_NAMEs: HWANG, GEELSU  (contact)

PROGRAM_OFFICER_NAME: MCNEALY, TAMARA L

PROJECT_TERMS: Acids;Address;Adhesions;Adhesives;Antimicrobial Resistance;Bacteria;Bacterial Adhesion;bactericide;Barium;Binding;Biocompatible Materials;biomaterial compatibility;Bite Force;Candida albicans;Cells;Characteristics;Clinical;clinical application;clinically relevant;Composite Dental Resin;cost comparison;cytotoxicity;Data;Dental;Dental caries;design;Development;efficacy evaluation;Electric Stimulation;electrical potential;electrical property;Electron Transport;Electrostatics;Environment;Exhibits;experimental study;Failure;Fluorescence;functional restoration;fungus;Future;Goals;Histologic;Homeostasis;Human;Hydrophobicity;Impairment;In Vitro;in vivo;in vivo Model;Incubated;Individual;Infection;innovation;Long-Term Effects;Mastication;mathematical model;Measures;mechanical force;mechanical properties;metallicity;Methodology;Microbe;microbial;Microbial Biofilms;microbial colonization;microbiota;microbiota composition;Microfluidics;microleakage;microorganism;Modality;Modeling;Motion;nanocomposite;nanoparticle;novel;Oral;Oral cavity;oral microbial community;Outcome;pathogenic bacteria;Performance;polymicrobial biofilm;Population;prevent;Prevention strategy;Property;real-time images;response;restoration;restorative material;Risk Reduction;Rodent;Rodent Model;Streptococcus gordonii;Streptococcus mutans;Surface;Surface Properties;System;Testing;Thick;Tooth structure;Tooth Tissue;Toothbrushing;Work;zeta potential

PROJECT_TITLE: Bacterial Adhesion Inhibition and Biofilm Disruption by Adaptive Piezoelectric Biomaterial

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]


NIH_SPENDING_CATS: Behavioral and Social Science;HIV/AIDS;Mental Health

PI_NAMEs: SLUSHER, BARBARA STAUCH (contact)

PROJECT_TERMS: Academia;Acceleration;Achievement;Address;Anhedonia;Animals;Anxiety;Architecture;arm;Arousal and Regulatory Systems;assay development;Awareness;Basic Science;Behavioral;Biological;Biological Assay;Biological Markers;Capital;CD34 gene;Clinical;Clinical Research;Clinical Trials;Cognition;Cognition Disorders;Collaborations;Commercial Sectors;Communities;comorbidity;Dedications;design;Development;drug candidate;drug discovery;Drug Kinetics;drug metabolism;Education;efficacy evaluation;experience;Faculty;Fellowship;forced swim test;Funding;Glutamates;Goals;HIV;HIV-1;holistic approach;humanized mouse;in vivo;Individual;Industrialization;Industry;innovation;Insulin;interest;Internships;Joints;lipid metabolism;Measures;Medicine;member;Mission;Modeling;mouse model;multidisciplinary;Mus;National Institute of Mental Health;Negative Valence;neuroAIDS;neurobehavioral;neuropsychiatry;novel;novel therapeutics;Persons;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;pharmacologic;Pharmacology;Pharmacology and Toxicology;Phenotype;Play;Positioning Attribute;Positive Valence;Postbaccalaureate;Postdoctoral Fellow;Pre-Clinical Model;preclinical efficacy;preference;programs;Radial;Regulation;Research;Research Activity;Research Domain Criteria;Research Personnel;Resources;Role;Scientist;screening;Series;Services;Severities;Sleep;social;Social Processes;Structure;Students;Sucrose;symposium;System;Testing;Therapeutic;Therapeutic Agents;therapeutic target;Training;Training and Education;Translating;Translational Research;treatment center;Underrepresented Minority;Veterans;water maze;web site

PROJECT_TITLE: JHU Center for the Advancement of HIV Neurotherapeutics (JHU CAHN)- Therapeutic Core


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Data Science;HIV/AIDS;Infectious Diseases;Mental Health;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Precision Medicine

PI_NAMEs: RUBIN, LEAH HELANE (contact)

PROJECT_TERMS: Acceleration;Address;Affective;Affective Symptoms;AIDS clinical trial group;Algorithms;Anhedonia;Anxiety;anxiety symptoms;Attention;Behavior assessment;Behavioral;Big Data;Bioinformatics;Brain;Caring;Central Nervous System;Charities;Clinical;Clinical Data;clinical phenotype;Clinical Trials;Cognition Disorders;Cognitive;Cognitive Therapy;cohort;Cohort Studies;Collaborations;Communities;Critical Pathways;Data;Data Analyses;Data Collection;data harmonization;data management;data quality;Dedications;Endowment;Epidemiologist;experience;Fright;Functional disorder;Funding;Genetic;Growth;Health Sciences;Heterogeneity;HIV;HIV-associated neurocognitive disorder;human data;Image;Impaired cognition;improved;Individual;innovation;insight;Insulin;International;Knowledge;Laboratories;Learning;Life Experience;Machine Learning;maladaptive behavior;Matched Group;mathematical model;Measurement;Measures;member;Memory;Mentors;Mentorship;Modeling;Molecular;mood symptom;Moods;multidimensional data;multidisciplinary;National Institute of Mental Health;neuroAIDS;neuroimaging;neuropsychiatry;next generation;novel therapeutics;outreach program;Patient Self-Report;Patients;Pattern;personalized medicine;Persons;Phase;Phenotype;pilot trial;Placebos;Positioning Attribute;Postdoctoral Fellow;precision medicine;programs;Psychiatrist;Research;Research Domain Criteria;Research Personnel;Resources;response;Scientist;Services;Sleep;social;student mentoring;Support Groups;Symptoms;System;therapeutic development;therapeutic target;therapeutically effective;Time;treatment response;Underrepresented Minority;United States National Institutes of Health;Viral;Withdrawal

PROJECT_TITLE: JHU Center for the Advancement of HIV Neurotherapeutics (JHU CAHN)- Clinical Core


NIH_SPENDING_CATS: Infectious Diseases;Nutrition

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: PROJECT NARRATIVE At any given time, humans are infected with multiple pathogens. The interaction of more than one pathogen in an infected host is poorly understood, because most experimental systems focus on single infections with individual pathogens. This work will examine how co-infections with a gammaherpesvirus and an intestinal parasite are different than single infections in mice.

PI_NAMEs: REESE, TIFFANY ANNE (contact)

PROGRAM_OFFICER_NAME: ALARCON, RODOLFO M

PROJECT_TERMS: Acids;Address;Animals;Biology;Bone Marrow;Breeding;Cell Physiology;chronic infection;co-infection;cytokine;Data;Deposition;Diet;dietary;Distal;embryonic stem cell;Epigenetic Process;gammaherpesvirus;Genome;Goals;Grant;helminth infection;Helminths;Herpesviridae;Herpesviridae Infections;Histones;Human;Immune;Immune response;Immune system;immunoregulation;Individual;Infection;insight;Interleukin-4;Intestinal parasite;Intestines;Macrophage;Maintenance;Modification;mouse model;Mus;Nematospiroides dubius;Parasites;Parasitic infection;pathogen;Peritoneal;Peritoneal Macrophages;Peritoneum;Persons;Phenotype;Population;progenitor;reactivation from latency;Reporting;response;Role;Science;Signal Transduction;System;Time;Tissues;Tretinoin;Viral Genome;virtual;Virus;Virus Activation;Virus Diseases;Virus Latency;Vitamin A;Vitamin A Deficiency;Work

PROJECT_TITLE: Defining Mechanisms for Parasite-Driven Effects on Gamma-Herpesvirus Latency

STUDY_SECTION: VIRB

STUDY_SECTION_NAME: Virology - B Study Section[VIRB]