NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Rehabilitation

ORG_CITY: WOOSTER

ORG_NAME: PRENTKE ROMICH COMPANY

PHR: NARRATIVE:  The proposed project is relevant to public health because it will establish brain-computer interface (BCI) access to an existing line of augmentative and alternative communication (AAC) systems providing a voice to those who otherwise are isolated from their family members and society. The combined AAC-BCI system will provide precise language production supported by a broad network of clinical support personnel for those who cannot communicate through physical movements. This will fulfill the mission of the NIH to reduce disability and enhance health by improving the quality-of-life for those with the most extreme physical impairments by creating an AAC-BCI device designed for compatibility with established communication, product delivery, and funding mechanisms.

PI_NAMEs: HILL, KATYA J;HUGGINS, JANE E;MALCOMSON, SHAWN  (contact)

PROGRAM_OFFICER_NAME: MILLER, ROGER

PROJECT_TERMS: Adopted;Algorithms;alternative communication;Amyotrophic Lateral Sclerosis;Augmentative and Alternative Communication;automated algorithm;brain computer interface;Calibration;Cerebral Palsy;Characteristics;Clinical;Clinical Competence;Clinical Services;Clinical Trials;commercial prototype;commercialization;commercialization readiness;Communication;Competence;Complex;Computer software;Country;Data;Degenerative Disorder;design;Detection;Development;Device Designs;disability;Documentation;dosage;efficacy testing;Electroencephalography;Engineering;Ensure;European;experience;Eye;Family member;Funding Mechanisms;Future;gaze;Goals;Hand;Head;Health;Home;Human Resources;Impairment;improved;Individual;innovation;International;Interview;Laboratories;Language;life span;Maintenance;Medical Device;Methods;Mission;Monitor;Movement;online resource;Participant;Pathway interactions;Peripheral;Persons;Phase;physical impairment;Population;power consumption;preference;prevent;Production;programs;prototype;Public Health;Qualifying;Quality of life;Readiness;Regulation;Resources;Risk;Safety;satisfaction;screening;Services;Small Business Innovation Research Grant;Small Business Technology Transfer Research;Societies;software development;support network;Support System;Surveys;System;Techniques;Testing;Text;touchscreen;Trainers Training;Training;Training Support;United States Centers for Medicare and Medicaid Services;United States National Institutes of Health;User-Computer Interface;virtual;Voice;Work

PROJECT_TITLE: Compatibility Between Brain-Computer Interface and High Efficiency Augmentative and Alternative Communication Systems: Commercial Readiness


ADMINISTERING_IC: MH

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Prevention;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC

ORG_STATE: NY

PI_NAMEs: WAINBERG, MILTON L (contact)

PROJECT_TERMS: access disparities;Address;Affect;AIDS prevention;Area;behavioral and social science;behavioral study;career;Caring;clinical center;Clinical Research;community based participatory approach;community partners;COVID-19;Data;data dashboard;design;Diagnosis;digital technology;Discipline;Disparity;disparity reduction;effective intervention;Epidemic;Equity;evidence base;Evidence based intervention;Failure;Goals;Health;health disparity;health equity;health inequalities;Health system;HIV;HIV diagnosis;HIV disparities;implementation framework;implementation science;implementation strategy;Improve Access;improved;Inequity;innovation;intersectionality;Intervention;lens;low and middle-income countries;marginalization;marginalized population;Measurement;Mediating;member;Mental Health;Mental Health Services;Methods;Minority;Minority Groups;Modeling;Monkeypox;Online Systems;Outcome;Patients;Phase;poor health outcome;Population;Prevention;programs;Provider;Public Health;Readiness;Research;Research Personnel;Research Support;Resource-limited setting;Resources;response;Role;scale up;Science;screening;Services;Shapes;social determinants;social health determinants;social science research;Substance abuse problem;substance misuse;surveillance data;Technology;Time;Underrepresented Populations;Vulnerable Populations;Work

PROJECT_TITLE: HEALTH EQUITY CORE


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: SEATTLE

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative This study will contribute to the understanding of the causes of the most common form of neurodegeneration: Alzheimer’s disease. If the hypothesis of this project is true, somatic mitochondrial mutations will be supported as a link between aging, neurodegeneration and mitochondrial dysfunction and that will contribute to elucidate how external factors contribute to Alzheimer’s disease and how to prevent it. Understanding the contribution of mitochondrial mutation to Alzheimer’s disease can be applied to develop preventive strategies that enhance mitochondrial function, promote successful aging, and improve early detection and quality of life of Alzheimer’s disease patients.

PI_NAMEs: SANCHEZ-CONTRERAS, MONICA YICETTE (contact)

PROGRAM_OFFICER_NAME: HAAKENSON, CHELSEA MARIE

PROJECT_TERMS: adeno-associated viral vector;Age;aged;Aging;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease patient;amyloid pathology;apoB mRNA editing catalytic subunit;Apoptosis;Area;Automobile Driving;Autopsy;Biogenesis;Biology;Biology of Aging;Brain;Brain region;brain tissue;career development;Cell Death;Cell Differentiation process;Cells;Collaborations;Country;Data Analyses;Data Science;Dementia;design;Development;Development Plans;Disease;disease stressor;DNA;Doctor of Philosophy;Early Diagnosis;early onset;Electron Transport;Ensure;entorhinal cortex;Evaluation;Event;Faculty;Foundations;Functional disorder;Genes;Genetic;Genome;Goals;Health;heteroplasmy;Hippocampus;Human;Impaired cognition;improved;in vivo Model;Institution;instructor;Knowledge;Laboratories;Lead;Link;Measures;Medicine;Mentored Research Scientist Development Award;Mentors;Mentorship;Metabolic Pathway;Mitochondria;Mitochondrial DNA;mitochondrial DNA mutation;mitochondrial dysfunction;mitochondrial genome;Modeling;Molecular;mouse model;Mus;Mutagenesis;Mutation;Natural regeneration;Nerve Degeneration;neurogenetics;neuron loss;Neurons;neuropathology;Neurosciences;normal aging;Nuclear;Oxidative Phosphorylation;Pathogenesis;Pathogenicity;Pathologic;pathological aging;Pathology;Patients;Pattern;Performance;Physiology;Population;Positioning Attribute;pre-clinical;prevent;Prevention strategy;Procedures;Process;Productivity;programs;Protocols documentation;Publishing;Quality of life;Recycling;repaired;Research;Research Personnel;Resolution;response;Role;Scientist;Signal Transduction;skill acquisition;skills;Somatic Mutation;Structure;Synapses;synaptic function;Synaptosomes;Tauopathies;Testing;Training;Transfection;Transgenes;Universities;Washington

PROJECT_TITLE: Contribution of somatic mitochondrial DNA mutation to the transition from normal aging to Alzheimers disease

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development For Early Career Investigators Study Section [AGCD-2]


FUNDING_MECHANISM: NON-SBIR/STTR RPGS

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Genetics;Hearing Loss;Human Genome;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Mounting evidence suggests that age-related hearing loss (presbycusis) is linked to cognitive decline and de- mentia risk in older adults, yet the underlying mechanisms are unknown. By identifying specific shared genetic and environmental influences on age-related changes in hearing abilities, cognition, and putative blood bi- omarkers for dementia, our study will reveal novel biological candidates for the determinants of aging.

PI_NAMEs: BLANGERO, JOHN ;GLAHN, DAVID C;MATHIAS, SAMUEL ROBERT (contact)

PROGRAM_OFFICER_NAME: ST  HILLAIRE-CLARKE, CORYSE

PROJECT_TERMS: 18 year old;Age;age effect;age related;age related changes;Aging;aging brain;aging mechanism;aging population;Alzheimer's disease related dementia;Alzheimer's disease risk;American;Amyloid beta-42;Animals;Audiology;Auditory Threshold;Biological;Biological Markers;Blood;Blood specimen;Boston;Brain;Case/Control Studies;cochlear synaptopathy;Cognition;Cognitive;cognitive ability;cognitive skill;cohort;comorbidity;cost effective;Data;Dementia;dementia risk;design;Diagnosis;Elderly;endophenotype;Environmental Risk Factor;Ethnic Origin;Family history of;Follow-Up Studies;Future;Genes;Genetic;genetic pedigree;Genetic study;Genetic Variation;genome wide association study;Genomic Segment;Genomics;Genotype;Health;Health Sciences;Hearing;hearing impairment;Hearing Tests;Heritability;Human;Image;Impaired cognition;improved;indexing;Individual;insight;late life;Lead;Life;Link;Measures;Medical;Mental Health;Mexican Americans;Neurofilament-L;normal hearing;novel;older adult;Participant;Pathogenesis;pathological aging;Pathway interactions;Pediatric Hospitals;Pharmaceutical Preparations;Phenotype;physical conditioning;Physiological;pleiotropism;Population;Presbycusis;Prevalence;Principal Investigator;Quality of life;Random Allocation;Research;Research Personnel;Resources;Role;Sample Size;Sampling;Sensorineural Hearing Loss;Structure;tau Proteins;tau-1;Testing;Texas;trait;Universities;Variant;whole genome

PROJECT_TITLE: Shared Genetic and Environmental Influences on Age-Related Hearing Loss, Cognitive Decline, and Dementia Risk

STUDY_SECTION: NMBH

STUDY_SECTION_NAME: Neurological, Mental and Behavioral Health Study Section[NMBH]


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Aphasia;Assistive Technology;Behavioral and Social Science;Bioengineering;Brain Disorders;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Depression;Disability Research;Health Services;Mental Health;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Palliative Care;Prevention;Rehabilitation;Social Determinants of Health;Telehealth

ORG_CITY: MIAMI

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: FLORIDA INTERNATIONAL UNIVERSITY

ORG_STATE: FL

PHR: Project Narrative Alzheimer’s disease and related dementias (ADRD) are leading causes of disability and often result in communication deficits that can complicate ADRD caregiving and clinical care. The study team will work with stakeholders to develop and design a personalizable Assistive and Alternative Communication (AAC) device that relies on information technology (IT) and touchscreens to promote communication and personhood for persons with dementia. This study will integrate the AAC into an existing health IT intervention that already facilitates clinical communication between caregivers and healthcare providers and will evaluate use of the modified IT among triads of dementia caregivers, persons with dementia, and healthcare providers.

PI_NAMEs: BROWN, ELLEN LESLIE (contact);RUGGIANO, NICOLE

PROGRAM_OFFICER_NAME: GERALD, MELISSA S

PROJECT_TERMS: Address;African American;Alabama;alternative communication;Alzheimer's disease related dementia;American;Anomia;Aphasia;associated symptom;Attention;Attentional deficit;Behavior;Behavioral;bilingualism;biopsychosocial;care preference;Caregiver support;Caregivers;caregiving;Caring;Clinic;Clinical;Clinical assessments;clinical care;clinical decision-making;Collection;Communication;communication device;Communities;Compensation;Complex;Computer software;Conflict (Psychology);cost efficient;Data;data integration;Decision Making;Dementia;dementia care;Dementia caregivers;dementia caregiving;Depression screen;design;Desire for food;Devices;disability;Disadvantaged;dosage;Early Diagnosis;Education;Electronics;experience;Family;Family member;Feedback;flexibility;Friends;Funding;Future;Goals;Habits;health information technology;Health Personnel;Hispanic;Home;improved;Information Technology;Infrastructure;Institutionalization;Interactive Communication;Internet;Interpersonal Relations;Intervention;Knowledge;Measures;Medical;member;Memory;Memory Loss;Mental Depression;Mental Health;mobile application;Monitor;Moods;Multimedia;novel;older adult;Outcome;Patients;Periodicals;person centered;Personhood;Persons;Pilot Projects;Population;premature;Primary Progressive Aphasia;Provider;provider communication;psychosocial;psychosocial outcome;Quality of Care;Quality of life;Recommendation;recruit;Regimen;Research;Retrieval;rural residence;Secure;Self Efficacy;Services;skills;Sleep;sleep quality;Social isolation;Spanish;Spanish/English;Technology;technology intervention;Testing;Text;theories;Time;touchscreen;Training;Translating;trend;United States Agency for Healthcare Research and Quality;Work

PROJECT_TITLE: Integration of Health Information Technology and Promotion of Personhood in Family-Centered Dementia Care

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-D(56)R]


ADMINISTERING_IC: GM

ED_INST_TYPE: GRADUATE SCHOOLS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: BLOOMINGTON

ORG_DEPT: BIOLOGY

ORG_NAME: TRUSTEES OF INDIANA UNIVERSITY

ORG_STATE: IN

PHR: Project Narrative Faithful segregation of chromosomes underlies genome integrity in all organisms. This proposed research aims to identify the mechanisms by which broadly conserved structural maintenance of chromosomes (SMC) complexes organize and compact replicated chromosomes in the cell. Our studies have the potential to uncover the general principles of chromosome packaging and segregation relevant to all domains of life.

PI_NAMEs: WANG, XINDAN  (contact)

PROGRAM_OFFICER_NAME: VATAKIS, DIMITRIOS NIKOLAOS

PROJECT_TERMS: Address;ATP Hydrolysis;ATP phosphohydrolase;Bacillus subtilis;Bacteria;Bacterial Genome;Binding;Binding Sites;Cell Cycle;Cells;Centromere;chromatin immunoprecipitation;Chromatin Loop;Chromosome Arm;chromosome conformation capture;chromosome replication;Chromosome Segregation;Chromosome Structures;Chromosomes;cohesin;Complex;condensin;Cytology;Data;deep sequencing;dimer;DNA;DNA biosynthesis;Engineering;Eukaryota;Exhibits;experimental study;Genetic Transcription;Genome;genome integrity;genomic profiling;Goals;Growth;Head;In Vitro;in vivo;Interphase;Left;Life;Maintenance;Measures;Methods;Modeling;Molecular;novel;Organism;Plasmids;Play;Polymers;Process;Proteins;Reagent;recombinase;repaired;Replication Origin;Replicon;Reproductive Process;Research;Resolution;Rhizobium radiobacter;Rod;Role;segregation;Shapes;simulation;single molecule;Sister;Sister Chromatid;Site;Structure;System;Tail;Time;time use;tool;Work

PROJECT_TITLE: How bacterial SMC complexes organize chromosomes

STUDY_SECTION: PCMB

STUDY_SECTION_NAME: Prokaryotic Cell and Molecular Biology Study Section[PCMB]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Clinical Research;Emerging Infectious Diseases;Genetics;Infectious Diseases;Microbiome

ORG_CITY: PALO ALTO

ORG_NAME: PALO ALTO VETERANS INSTIT FOR RESEARCH

ORG_STATE: CA

PHR: PROJECT NARRATIVE  Antimicrobial resistance (AMR) is an increasingly prevalent and serious problem worldwide. A more detailed understanding of how AMR develops and spreads within the human gut microbiota in response to antibiotic exposure would enhance strategies for antibiotic stewardship. We will characterize the evolution and dissemination of antimicrobial resistance genes in the human gut microbiota before, during and after antibiotic exposure in vivo, as well as in complex microbial communities derived from stool samples of the same individuals in vitro, with the goal of identifying factors and conditions that will reduce the spread of AMR, leading to optimized antibiotic use and preservation of efficacy.

PI_NAMEs: RELMAN, DAVID A. (contact)

PROGRAM_OFFICER_NAME: RANALLO, RYAN

PROJECT_TERMS: Address;Adult;Affect;Antibiotics;antimicrobial;Antimicrobial Resistance;Bacteriophages;Biological Assay;chromosome conformation capture;Ciprofloxacin;Communicable Diseases;Communities;Complex;Data;de novo mutation;Development;Elements;emerging antimicrobial resistance;Environment;Event;Evolution;Feces;Genes;Genetic;Genome;Genomics;Goals;gut microbiome;gut microbiota;Horizontal Gene Transfer;Human;improved;In Vitro;in vivo;Individual;Infection;innovation;Knowledge;Laboratories;Link;metagenomic sequencing;Metagenomics;Methods;Microbe;microbial community;microbial genome;microbial host;Mobile Genetic Elements;Modernization;Monitor;mortality;pathogen;Pathogenicity;Plasmids;preservation;pressure;Prevalence;Protocols documentation;Recording of previous events;Resistance development;resistance gene;Resolution;response;Sampling;Source;stool sample;temporal measurement;tool;trend;Work

PROJECT_TITLE: Antimicrobial Resistance and Horizontal Gene Transfer in the Human Gut Microbiome in Response to an Antibiotic

STUDY_SECTION: GVE

STUDY_SECTION_NAME: Genetic Variation and Evolution Study Section[GVE]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

ORG_CITY: BERKELEY

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: Project Narrative The catalysts and reactions that are the subject of the proposed research will improve methods to prepare pharmaceutical candidates. New reactions, new applications of the catalytic reactions, and a mechanistic understanding of these systems will result from the proposed research. Thus, the successful development of the proposed research will continue the PI’s studies that have significantly increased the accessibility of compounds that improve human health.

PI_NAMEs: HARTWIG, JOHN F (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TITLE: Discovery and Development of Organic Reactions Catalyzed by Transition Metals Valuable for Medicinal Chemistry

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Genetics;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research

ORG_CITY: NEW HAVEN

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE The proposed project examines for the first time whether traditional Samoan age beliefs and a newly-identified CREBRF gene variant predict greater cognitive resilience including lower risk of dementia. To accomplish this, we will interview older Samoans because there is evidence that they tend to have a high level of cognitive resilience, traditional age beliefs are still prevalent among them, and close to half have the CREBRF gene variant, whereas less than 1% of non-Samoans have it. Our research is relevant to the National Institute on Aging’s mission of improving the cognitive health of older persons by examining novel determinants of cognitive resilience in diverse cohorts.

PI_NAMEs: LEVY, BECCA R (contact)

PROGRAM_OFFICER_NAME: BRAUDT, DAVID BRUCE

PROJECT_TERMS: Acculturation;Adherence;Age;aged;Ageism;Aging;Alzheimer's disease related dementia;Alzheimer’s disease biomarker;American;American Samoa;Attention;Belief;Biological;Blood Glucose;Brain;California;Cognition;Cognitive;Cognitive aging;cognitive benefits;cohort;community organizations;Country;Data;Data Set;Dementia;dementia risk;Development;Elderly;Environment;Environmental Risk Factor;Epidemiology;ethnic identity;ethnic minority population;Fasting;fasting blood glucose level;Future;gene interaction;Genes;Genetic;genetic variant;Health;Hippocampus;improved;Individual;Infrastructure;Intervention;Interview;Knowledge;Link;Location;low and middle-income countries;Measures;member;Memory;Meta-Analysis;mild cognitive impairment;Mission;Modeling;National Institute on Aging;Neuronal Plasticity;Non-Insulin-Dependent Diabetes Mellitus;novel;Older Population;Participant;Pathway interactions;Population;Principal Investigator;Property;psychologic;Qualifying;recruit;Reporting;Research;Research Personnel;Research Support;resilience;Risk;Samoa;Samoan;San Francisco;social;Stress;Time;United States;United States National Institutes of Health

PROJECT_TITLE: Cognitive Resilience among Older Samoans

STUDY_SECTION: SPIP

STUDY_SECTION_NAME: Social Psychology, Personality and Interpersonal Processes Study Section[SPIP]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Genetics;Human Genome;Mental Health;Neurosciences

ORG_CITY: BELMONT

ORG_NAME: MCLEAN HOSPITAL

PHR: Fear-related disorders such as Post-Traumatic Stress Disorder (PTSD) are often characterized by an inability to inhibit and extinguish fear memories leading to pathological expression of fear-related behaviors. For progress to occur with targeted rationally-designed therapeutic approaches, a greater understanding of the neural circuitry mediating fear inhibition and extinction is needed. This proposal uses cell-type specific modulation of cells within the amygdala to advance our understanding of circuitry underlying fear behaviors and will provide unique avenues for therapeutics.

PI_NAMEs: BOLSHAKOV, VADIM ;RESSLER, KERRY J. (contact)

PROGRAM_OFFICER_NAME: VICENTIC, ALEKSANDRA

PROJECT_TERMS: Affect;Amygdaloid structure;anxiety-related disorders;Behavior;Behavior Therapy;Calcium;Cell Nucleus;Cell Physiology;cell type;Cells;Chronic stress;conditioned fear;CRH gene;designer receptors exclusively activated by designer drugs;Disease;Dissection;Electrophysiology (science);Emotions;Exhibits;Exposure to;Extinction;fear memory;Fiber;Fright;Functional disorder;Future;Genes;Genetic;Genomics;Hippocampus;Impairment;Implant;in vivo;innovation;learning extinction;lens;Medial;Mediating;Memory;Methodology;Modeling;Modification;Molecular;Molecular Profiling;Molecular Target;Mus;National Institute of Mental Health;neural circuit;Neural Pathways;Neuronal Plasticity;Neurons;Neurosciences;novel;Nuclear RNA;Outcome;Pathologic;Pathway interactions;Pattern;pharmacologic;Photometry;Physiological;Pilot Projects;Population;Post-Traumatic Stress Disorders;Prefrontal Cortex;prevent;promoter;rational design;Refractive Indices;Regulation;Reporter;Research Domain Criteria;Research Priority;response;RNA;Role;Signal Transduction;Slice;Strategic Planning;Stress;Synapses;Synaptic plasticity;System;Testing;Therapeutic;tool;transcriptome sequencing;translational approach;translational study;Trauma;United States National Institutes of Health;Viral;Work

PROJECT_TITLE: Cell Type Specific Genomic and Functional Dissection of Fear-Off Amygdala Pathways

STUDY_SECTION: PMDA

STUDY_SECTION_NAME: Pathophysiological Basis of Mental Disorders and Addictions Study Section[PMDA]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Neurosciences;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

PHR: PROJECT NARRATIVE This proposal is responsive to the announcement NOT-DA-20-060, as the overarching goal of the study is to identify and characterize mechanistic pathways in astrocytes responsible for changes in drug-evoked structural and synaptic plasticity that underlie the maladaptive behavior in opioid drug abuse. To this end, we will examine how dysfunction in Beclin1-driven autophagic processes in astrocytes promotes opioid addiction, in HIV infection.

PI_NAMEs: EL-HAGE, NAZIRA  (contact);MCLAUGHLIN, JAY P.

PROGRAM_OFFICER_NAME: TSAI, SHANG-YI ANNE

PROJECT_TERMS: Acute;addiction;Address;Agonist;Anti-Inflammatory Agents;Antibodies;Area;Astrocytes;Autophagocytosis;Autopsy;Behavior;Behavioral;Behavioral Model;behavioral response;Binding Proteins;Binding Sites;Biochemical;Biological Assay;Brain;brain cell;brain tissue;Buprenorphine;C57BL/6 Mouse;cannabinoid receptor;Cells;chemokine;Chronic;Clinical;Coculture Techniques;comorbidity;conditioned place preference;cryostat;cytokine;Degradation Pathway;density;Detection;Development;Disease;dopaminergic neuron;Drug Addiction;drug seeking behavior;Drug usage;Electron Microscopy;energy balance;Energy Metabolism;Enzyme-Linked Immunosorbent Assay;experience;Exposure to;Flow Cytometry;Freezing;Functional disorder;Glutamate Metabolism Pathway;Glutamate Transporter;Glutamates;Goals;Golgi Apparatus;Growth Factor;Harvest;Health;Hematoxylin and Eosin Staining Method;High Pressure Liquid Chromatography;Histology;HIV;HIV Infections;Homeostasis;human disease;Imaging Techniques;Immune system;Immunoassay;Immunohistochemistry;Impairment;In Vitro;in vivo;Individual;Inflammation;insight;Interneurons;Investigation;Knowledge;Label;lens;Ligands;liquid chromatography mass spectrometry;Liquid substance;long term abstinence;Lysosomes;maladaptive behavior;Maps;Measures;Mediating;Methadone;Morphine;mouse model;mu opioid receptors;Mus;Naltrexone;neuroadaptation;Neuroanatomy;neurochemistry;Neuroglia;Neuroimmune;neuroinflammation;neuronal circuitry;Neuronal Dysfunction;Neurons;Neurotransmitters;new therapeutic target;Nitrogen;Opiate Addiction;Opioid;opioid abuse;Opioid Antagonist;opioid exposure;opioid injection;Opioid Receptor;opioid use;opioid use disorder;opioid withdrawal;Pain;painful neuropathy;Pathology;Pathway interactions;Pharmaceutical Preparations;Physiology;Population;postsynaptic neurons;prevent;Process;Production;Proteins;Proteomics;Recycling;Regulation;Relapse;release factor;Resolution;response;Rewards;Risk;Role;Self Administration;Series;Signal Transduction;Structure;Synapses;synaptic function;Synaptic plasticity;synaptogenesis;System;Testing;Tissue Harvesting;Tissues;trafficking;uptake;Vertebral column;Western Blotting;Withdrawal

PROJECT_TITLE: Function of astrocytes autophagy in brain homeostasis and opioid-induced maladaptive behavior and addiction, in the context of HIV

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Immunotherapy;Lewy Body Dementia;Neurodegenerative;Neurosciences;Parkinson's Disease

ORG_CITY: ATHENS

ORG_NAME: UNIVERSITY OF GEORGIA

ORG_STATE: GA

PHR: NARRATIVE The pathological hallmark of Lewy body diseases is the presence of Lewy bodies (LBs), which are composed of abnormal aggregates of the alpha-synuclein (α-syn) protein. We propose to investigate whether natural killer (NK) cells have the capacity to protect neurons by clearing α-syn aggregates and modulating inflammation. The completion of our study will yield ample novel data to interrogate NK cell function in age-related neurodegenerative diseases and provide a rationale for potential immune cell target strategies.

PI_NAMEs: LEE, JAE KYUNG  (contact)

PROGRAM_OFFICER_NAME: SULLIVAN, LUIS FLANAGAN

PROJECT_TERMS: Address;Age;age related neurodegeneration;Allogenic;alpha synuclein;antimicrobial;Attenuated;Autopsy;B-Lymphocytes;Blood;Brain;Cancerous;Cell Count;Cell Physiology;Cells;Cellular Immunity;chemokine;Corpus striatum structure;Data;Disease Progression;Enteric Nervous System;extracellular;Extracellular Fluid;gamma-Chemokines;gastrointestinal system;gut homeostasis;Immune;Immune response;Immune system;Immunotherapeutic agent;In Vitro;in vivo;Infiltration;Inflammation;Infusion procedures;innovation;interest;Leukocytes;Lewy Bodies;Lewy Body Dementia;Lewy Body Disease;Lewy body pathology;Ligands;Lymphocyte;Mediating;member;Microglia;migration;Monitor;Motor;mouse model;Multiple System Atrophy;Mus;Natural Killer Cells;Nerve;Nerve Degeneration;Nervous System Disorder;neuroinflammation;Neurons;neuropathology;neuroprotection;neurotoxicity;novel;Outcome;Parkinson Disease;Pathogenesis;Pathologic;Pathology;Patients;Peripheral;peripheral blood;Phenotype;Physiological;Play;pre-clinical;Proteins;receptor;receptor binding;receptor expression;repaired;Reporting;Research;Role;Scheme;senescent cell;Severity of illness;Substantia nigra structure;Surface;synuclein;synucleinopathy;T-Lymphocyte;Testing;Tissues;Travel;Virus;Work

PROJECT_TITLE: Elucidating the role of NK cells in Lewy body diseases

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Rehabilitation;Rural Health;Social Determinants of Health

ORG_CITY: PORTLAND

ORG_DEPT: PEDIATRICS

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE Up to 1 in 5 US children experiences a communication disorder before age 6, causing long-term social, emotional, behavioral, academic, physical health, and mental health risks. Early Intervention improves outcomes; however, children from racial, ethnic, and/or linguistic minority populations, including those living in rural areas and/or poverty, have less access to timely, accurate identification and high-quality communication disorder treatment. Using stakeholder engagement methods and data from over 100,000 children in five states, we will identify key sources of structural racism and discrimination for children with communication disorders in the Early Intervention system and use findings to develop actionable practice and policy recommendations.

PI_NAMEs: CYCYK, LAUREN M.;ZUCKERMAN, KATHARINE ELIZABETH (contact)

PROGRAM_OFFICER_NAME: STORKEL, HOLLY LYNN

PROJECT_TERMS: Address;Administrator;Adult;Advocate;Affect;Age;Attitude;autism spectrum disorder;Behavioral;Belief;Big Data;Caring;Characteristics;Child;Child Care;Child health equity;child services;Child Support;Childhood;children of color;Clinical;Color;Communication;Communication impairment;Communities;community-level factor;Complex;Consensus;Criminal Justice;Data;Development;disability;Discrimination;Disparity;early childhood;Early identification;Early Intervention;early satiety;Early treatment;Education;Eligibility Determination;Emotional;Equity;Ethnic Origin;Evaluation;Evidence based intervention;Exclusion;experience;Face;Family;Family Characteristics;Focus Groups;Foundations;Funding;Goals;Health;Health Care Costs;Health Disparities Research;health disparity;health inequalities;Health Services Accessibility;hearing impairment;Home;Human;improved;improved outcome;Individual;Individuals with Disabilities Education Act;inequitable distribution;Information Systems;innovation;Intervention;Interview;Language;Language Disorders;Leadership;Linguistics;Locales;marginalized population;member;Mental Health;Methods;Minority Groups;National Institute on Deafness and Other Communication Disorders;Organizational Policy;Outcome;Parents;Pathologist;Personal Satisfaction;physical conditioning;Policies;policy recommendation;Population;Poverty;Poverty Areas;Primary Care Physician;Process;programs;Provider;provider intervention;Race;Recommendation;Regulation;Reproducibility;Research;Resources;Risk;Rural;rural area;rural poverty;School-Age Population;service intervention;service providers;Services;social;Source;Specialist;Speech;Speech Disorders;stakeholder perspectives;structural determinants;Structural Racism;Structure;Surveys;Symptoms;System;Techniques;US State;Variant

PROJECT_TITLE: Addressing Structural Disparities for Children with Early Communication Disorders (ASCEND)


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Contraception/Reproduction;Dissemination and Implementation Research;HIV/AIDS;Health Services;Infectious Diseases;Mental Health;Pediatric;Pediatric - AIDS;Prevention;Women's Health Research

PHR: PROJECT NARRATIVE Pre-exposure prophylaxis (PrEP) is a highly effective user-controlled HIV prevention strategy, with tremendous potential for high impact to reduce incident HIV infections among at-risk African women if delivered with high coverage and taken with sufficient adherence. In this highly innovative study, we propose to catalyze integration of optimized universal screening and counseling for HIV risk behaviors and PrEP provision for at-risk women accessing public health family planning clinics in Kisumu, Kenya – a region with an HIV prevalence of up to 28% among young women– using step-wedged randomized design. We hypothesize that family planning clinics will offer a cost- and time-efficient, less stigmatizing, and sustainable woman-centered ‘one-stop’ access point for PrEP and FP services, with culminating in great reach and impact for PrEP of reducing incident HIV infection in this setting.

PI_NAMEs: MUGWANYA, KENNETH KIGGUNDU (contact)

PROGRAM_OFFICER_NAME: SENN, THERESA ELAINE

PROJECT_TERMS: Address;Adherence;Adolescent;Adoption;Africa;African;African Women;AIDS prevention;Area;Benchmarking;Blood;budget impact;Budgets;Caring;Characteristics;Client;Clinic;clinic ready;Clinical Research;Clinical Trials;Cluster randomized trial;Collaborations;Consolidated Framework for Implementation Research;Contraceptive methods;Contraceptive Usage;cost;cost estimate;Counseling;Country;County;Data;Dedications;design;disability-adjusted life years;Dryness;Effectiveness;Epidemic;Evaluation;Face;Family Planning;feasibility testing;Feedback;Financial cost;Formulation;Future;Health;Health system;High Risk Woman;HIV;HIV Infections;HIV risk;Human immunodeficiency virus test;implementation barriers;implementation evaluation;implementation framework;implementation strategy;implementation/effectiveness;improved;Incidental Findings;incremental cost;infection risk;informant;innovation;Institutionalization;Intervention;Interview;Kenya;Left;Location;Maintenance;Maps;Methods;microcosting;Modeling;multidisciplinary;next generation;opportunity cost;Oral;organizational readiness;Outcome;Pilot Projects;Policies;Population;Populations at Risk;pre-exposure prophylaxis;Prevalence;Prevention;prevention service;Prevention strategy;Process;programs;Protocols documentation;Provider;Public Health;Randomized;randomized trial;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Readiness;Reproductive Health Services;Research;Resource-limited setting;Risk;Risk Behaviors;Risk Factors;Safety;scale up;screening;secondary analysis;Service provision;Services;sexual and reproductive health;sexually active;Sexually Transmitted Diseases;social stigma;Spottings;Stigmatization;Supervision;supply chain;System;Tenofovir;Testing;Time;Time and Motion Studies;tool;Training;trial design;Trust;uptake;Visit;Woman;Work;young woman

PROJECT_TITLE: Integrating PrEP delivery in family planning clinics in Kenya

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Data Science;Drug Abuse (NIDA only);Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Precision Medicine;Prevention;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: MADISON

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Project Narrative Precision mental health offers a way to optimize therapeutic benefit of existing treatments by using individual difference characteristics to select the treatment predicted to work best for a given patient. Existing precision mental health research has been unable to capture the complexity of clinical phenomena like treatment response and produces models that do not generalize well to new data; however, contemporary machine learning approaches are well-suited to overcome these limitations. The project at the center of this training grant will apply machine learning to build a precision mental health model from clinical and genetic individual differences that guides treatment selection for cigarette smoking cessation, reducing the personal and public health burden of cigarette smoking.

PI_NAMEs: FRONK, GAYLEN E (contact)

PROGRAM_OFFICER_NAME: LAO, GUIFANG

PROJECT_TERMS: Abstinence;Acceleration;Address;career;Caring;Characteristics;cigarette smoking;Clinical;Clinical Data;clinical practice;Clinical Trials;Complex;cost;Data;Data Sources;Development;Effectiveness;Engineering;experience;FDA approved;Fellowship;Genetic;genetic analysis;Genetic Models;Goals;Grant;health goals;high dimensionality;improved;Individual;Individual Differences;Interdisciplinary Study;Knowledge;knowledge integration;Machine Learning;machine learning model;Mental Health;Mentorship;Methods;model building;Modeling;non-genetic;novel;Outcome;Patients;Performance;Persons;Pharmaceutical Preparations;Phenotype;Population;precision medicine;Prediction of Response to Therapy;Prevalence;prevent;Probability;programs;prospective;psychologic;Public Health;Randomized, Controlled Trials;Recovery;Research;Sampling;Selection for Treatments;Signal Transduction;skills;Smoke;Smoking;smoking abstinence;smoking cessation;Smoking Cessation Intervention;Substance Use Disorder;success;Techniques;Therapeutic;Training;Treatment Effectiveness;Treatment outcome;treatment response;Validation;Work

PROJECT_TITLE: Machine learning-assisted precision mental health for cigarette smoking cessation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F16-L(20)L]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Dental, Oral, and Craniofacial Disease;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Primary Health Care;Social Determinants of Health

ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: PROJECT NARRATIVE The study will provide evidence on how changes in access to dental services affect overall health status of low-income adults who became recently eligible for Medicaid with dental benefits. The evidence is useful for understanding how oral health and access to care affect health more broadly, and will inform national discussions about other policies to cover dental services.

PI_NAMEs: WEHBY, GEORGE L (contact)

PROGRAM_OFFICER_NAME: IIDA, HIROKO

PROJECT_TERMS: access restrictions;Accounting;Adult;Affect;Affordable Care Act;Age;Cardiovascular Diseases;care providers;Caring;Childhood;Community Dentistry;Complex;Cost Analysis;Costs and Benefits;Data;Data Set;Data Sources;Dental;Dental Care;Dental caries;Dentists;Diabetes Mellitus;Disease;Effectiveness;effectiveness evaluation;Elderly;Emergency Situation;Employment;Enrollment;Ethnic Origin;Evaluation;federal poverty level;Goals;Health;health care availability;health economics;Health Personnel;Health Services;Health Services Research;Health Status;Heterogeneity;High-Income Populations;Improve Access;improved;Income;Individual;Insurance;Knowledge;Low Birth Weight Infant;Low income;Medicaid;Medicaid eligibility;Medical;Medicare;Mental Health;Natural experiment;Neighborhoods;older adult;Oral health;Periodontal Diseases;Personal Satisfaction;physical conditioning;Policies;Policy Maker;Policy Research;Population;Positioning Attribute;preference;Premature Birth;Preventive;Preventive dental care;Preventive Dentistry;Preventive service;Privatization;programs;psychosocial;Quality of life;Quasi-experiment;Race;Research Personnel;Science;Services;sex;skills;Socioeconomic Status;Surveys;Time;United States;Variant;Visit

PROJECT_TITLE: Spillover Effects of Medicaid Dental Coverage Expansions on Health Status


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Physical Activity;Prevention;Racial and Ethnic Minority Health Research

ORG_CITY: COLUMBIA

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

ORG_STATE: SC

PHR: The escalating number of older adults suffering from Alzheimer's disease and related dementias (ADRD) has existed as an urgent public health crisis worldwide. This project applies novel methodology to determine if day- to-day variability and volume of lower-intensity lifestyle activities are joint intervention targets to sustain cognitive function in vulnerable older adults. Verifying these putative lifestyle behavioral targets is essential to establish evidence-based foundations for developing achievable, sustainable, and ecologically-valid strategies to sustain optimal cognition and reduce ADRD risks in late life.

PI_NAMEs: YANG, CHIH-HSIANG  (contact)

PROGRAM_OFFICER_NAME: KING, JONATHAN W

PROJECT_TERMS: Accelerometer;Adult;Aerobic Exercise;Age;age difference;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Behavioral;Behavioral Model;Cellular Phone;Cognition;Cognitive;cognitive benefits;cognitive function;cognitive testing;Data;Data Set;Dementia;dementia risk;demographic disparity;demographics;Devices;Dimensions;disease registry;Distal;Economic Burden;efficacy trial;eligible participant;Enrollment;ethnic difference;ethnic diversity;Ethnic Origin;evidence base;Exercise;Expenditure;experience;Family;follow-up;Foundations;Funding;Future;Gender;gender difference;Goals;Guidelines;Health;Health Care Costs;Heterogeneity;high risk;human old age (65+);Impaired cognition;Incidence;Individual;Intervention;Joints;Knowledge;late life;Life Style;Light;light intensity;Literature;longitudinal design;Masks;Measurement;Measures;Medical;Medicine;Mental Health;Methodology;Methods;mobile computing;Modeling;Monitor;Motivation;Noise;novel;older adult;Older Population;Outcome;Participant;Pattern;pedometer;Persons;Phase;Physical activity;Population;pre-clinical;prevent;Prevention strategy;programs;prospective;Prospective, cohort study;Public Health;Race;racial difference;Recommendation;recruit;Reliability of Results;Reporting;Research;Resources;Risk;Role;Sampling;sex;Sex Differences;Sleep;sleep quality;social;social engagement;Societies;Statistical Methods;statistics;Stress;Subgroup;success;Surveys;Testing;therapy development;Time;tool;Uncertainty;United States National Institutes of Health;Variant;Walking

PROJECT_TITLE: Variability and Volume of Day-to-Day Lifestyle Activity in Sustaining Cognitive Function among Insufficiently Active Older Adults at Risk for Alzheimer's Disease and Related Dementias

STUDY_SECTION: LCBH

STUDY_SECTION_NAME: Lifestyle Change and Behavioral Health Study Section[LCBH]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Biomedical Imaging;Breastfeeding, Lactation and Breast Milk;Neurosciences;Nutrition;Pediatric

ORG_CITY: Nashville

ORG_DEPT: PHYSIOLOGY

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: Nutrition, hormones and other environmental factors act during development to affect individual susceptibility to obesity throughout life. As the master regulator of energy balance, the hypothalamus plays a central role in such ‘programming’ of obesity; maternal nutrition impacts energy balance in the offspring, effects that persist throughout life. In this project we propose to carry out a brain-wide analysis of how maternal exposure to high fat diet during lactation impacts the organization and function of neural circuits that are known to regulate energy balance, with direct implications for environmental modification of body weight and metabolic health.

PI_NAMEs: SIMERLY, RICHARD B (contact)

PROGRAM_OFFICER_NAME: COOKE, BRAD

PROJECT_TERMS: Address;Adult;Affect;Architecture;awake;Behavioral;Body Weight;Brain;Brain imaging;Brain region;Calcium;Cell Nucleus;cell type;Cerebral cortex;Cues;Data;Development;developmental neurobiology;Endocrine;energy balance;Environmental Risk Factor;Esthesia;Exposure to;feeding;Feeding behaviors;fluorescence imaging;Health;High Fat Diet;Hormones;Hypothalamic structure;Image;in vivo;in vivo imaging;Individual;insight;Label;Lactation;Lateral;Leptin;Life;Light;Maternal Exposure;Mediating;Metabolic;metabolic phenotype;microendoscopy;Modification;mother nutrition;Mus;neural;neural circuit;neural network;Neural Pathways;neurobiological mechanism;Neurons;Neurophysiology - biologic function;Nucleus solitarius;nutrition;Obesity;offspring;Output;paraventricular nucleus;Pathway interactions;perinatal environment;Play;Population;postnatal;postsynaptic neurons;Predisposition;Process;Property;Prosencephalon;Recommendation;Regulation;response;Role;Sensory;Signal Transduction;Stimulus;Structure;Structure of nucleus infundibularis hypothalami;System;Testing;Text;Tissues;transmission process;Vagus nerve structure;Viral

PROJECT_TITLE: Developmental Programming of Neural Circuits Impacting Hypothalamic Integration

STUDY_SECTION: BNRS

STUDY_SECTION_NAME: Behavioral Neuroendocrinology, Neuroimmunology, Rhythms, and Sleep Study Section [BNRS]


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Neurosciences;Sleep Research

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: NARRATIVE Sleep-wake disturbances are associated with important adverse outcomes in older persons, including cognitive and functional decline. These disturbances are under-diagnosed in older persons due to the poor sensitivity of existing sleep questionnaires, the frequent co-occurrence of multiple disturbances, and the burdensome nature of objective sleep testing. We propose to develop and test age-appropriate, comprehensive subjective and objective sleep assessment tools to facilitate identification of older persons with sleep-wake disturbances.

PI_NAMEs: MINER, BRIENNE  (contact)

PROJECT_TERMS: Academy;actigraphy;Address;Adverse effects;adverse outcome;Age;Aging;aging related;American;Assessment tool;Award;Awareness;Capsicum;career;career development;circadian biology;clinical epidemiology;clinical training;cohort;Data;Detection;Development;Device or Instrument Development;Diagnosis;Drowsiness;Elderly;Electroencephalography;Environment;epidemiology study;Etiology;expectation;experience;flexibility;Foundations;functional decline;Functional impairment;Future;Geriatrics;Gills;Goals;Grant;Health;Home environment;human old age (65+);Hypersomnias;Impaired cognition;Impairment;improved;improvement on sleep;Institutionalization;instrument;International;Intervention;Interview;K-Series Research Career Programs;Laboratories;leadership development;Measures;medical schools;Medicine;Mentors;Methods;Minority Groups;Morbidity - disease rate;mortality;Nature;Nocturia;Normal Range;novel;Older Population;Outcome;Patient Self-Report;Perception;Persons;Phase;Physical Performance;Physicians;pilot test;Polysomnography;poor sleep;Population;prevent;programs;Publications;Qualitative Methods;Questionnaires;Reference Standards;Reporting;Research;research and development;Research Design;Research Methodology;Research Personnel;Research Project Grants;Research Training;Resources;response;Schedule;screening;Sleep;Sleep Apnea Syndromes;Sleep Deprivation;Sleep Disorders;Sleep disturbances;sleep health;sleep quality;Sleeplessness;Societies;Specialist;standard measure;success;Symptoms;Testing;therapeutic target;tool;training opportunity;Training Programs;United States National Institutes of Health;Universities;vigilance;Work

PROJECT_TITLE: Evaluating Sleep Deficiency in Aging Populations


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: CORAL GABLES

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

PHR: Project Narrative This is a proposal for a hybrid 2 implementation-effectiveness randomized controlled trial (RCT) of FINISHING HIV, an implementation strategy bundle of a social network support component and a one-stop-shop PrEP component to improve PrEP initiation of Latino men who have sex with men (LMSM). Our use of a social network support, one-stop-shop PrEP, and community and national pharmacy chain partners is a promising model that can be replicated in other EHE priority areas nationwide.

PI_NAMEs: KANAMORI NISHIMURA, MARIANO JUAN (contact)

PROGRAM_OFFICER_NAME: DEJLI, JAMAL

PROJECT_TERMS: Address;Adherence;Affect;Area;Attitude;Awareness;bilingualism;Blood;Caring;Charge;Client;Collaborations;Collection;Communities;community engagement;community partners;compare effectiveness;Consolidated Framework for Implementation Research;Consultations;contagion;contextual factors;Counseling;County;design;Diffusion;Diphosphates;Dryness;Effectiveness;effectiveness evaluation;effectiveness-implementation RCT;Emotional;empowerment;Enrollment;Environment;Epidemic;epidemic preparedness;Event;evidence base;Evolution;Florida;Fostering;Frequencies;Friends;Friendships;Funding;Gays;Health;Health behavior;Health Promotion;Hearing;high risk population;HIV;HIV diagnosis;Hybrids;implementation science;implementation strategy;improved;Information Services;Infrastructure;innovation;Insurance;Intervention;intervention effect;Knowledge;Latino;Latino Population;Logic;male;Mediator;men who have sex with men;Methods;Modeling;Network-based;Newly Diagnosed;Participant;patient assistance;peer;Penetration;personalized approach;Pharmacy facility;Population;pre-exposure prophylaxis;preference;Prevention;primary outcome;programs;Randomized;Randomized, Controlled Trials;rapid testing;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Reaction;recruit;Research;Respondent;Risk Reduction;Running;Sampling;Science;secondary outcome;Services;sex;social;social cohesion;social culture;Social Environment;Social Network;Social support;Spottings;support network;telehealth;Tenofovir;theories;transmission process;Visit;Visualization;Work

PROJECT_TITLE: FINISHING HIV: An EHE model for Latinos Integrating One-Stop-Shop PrEP Services, a Social Network Support Program and a National Pharmacy Chain


ADMINISTERING_IC: NR

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Biodefense and Related Countermeasures;Clinical Research;Dissemination and Implementation Research;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Lung;Prevention;Rare Diseases;Tuberculosis

ORG_CITY: CHESTNUT HILL

ORG_NAME: BOSTON COLLEGE

PHR: Project Narrative South Africa estimates 80% of their population has TB infection, and 14% of the population lives with HIV, with an estimated 5-15% of South Africans at high risk of developing TB disease from recent infection or immunocompromised status. Therefore, utilization of routinely collected data to optimize the comprehensive TB care cascade – screening, evaluation, diagnosing, linkage to care, treatment, and TB-free survival – is important to assess at the clinic level to improve clinic flow and patient outcomes. The proposed study will leverage an evidence-based implementation science strategy, the Systems Analysis and Improvement Approach (SAIA), and recent TB cascade analyses piloted in the proposed site, to adapt and evaluate the effectiveness of SAIA-TB using a stepped wedge crossover cluster randomized trial across 12 clinics in rural Eastern Cape, South Africa.

PI_NAMEs: VAN DE WATER, BRITTNEY JAYNE (contact)

PROGRAM_OFFICER_NAME: GODETTE, DIONNE

PROJECT_TERMS: acceptability and feasibility;Affect;Africa South of the Sahara;Area;Attitude;Award;Belief;Caring;Clinic;Clinical;clinical care;Cluster randomized trial;Collaborations;Communicable Diseases;Consolidated Framework for Implementation Research;cost;Country;Cross-Over Trials;Data;Data Analyses;design;Development;Diagnosis;Diagnostic;Disease;Drug resistance;drug-sensitive;Effectiveness;effectiveness evaluation;Eligibility Determination;Engineering;Evaluation;evidence base;evidence based guidelines;Family;Focus Groups;follow-up;global health;Health;Health Personnel;Health Services Accessibility;high risk;HIV;HIV Infections;HIV/TB;Home;Home visitation;Household;Immunocompromised Host;implementation process;implementation science;implementation strategy;improved;Individual;Infection;informant;innovation;insight;Intervention;Interview;Knowledge;Literature;Maps;Mentored Patient-Oriented Research Career Development Award;Methods;Modeling;patient engagement;Patient-Focused Outcomes;Patients;Performance;Persons;Policies;Population;Populations at Risk;Positioning Attribute;prevent;Prevention;Prevention program;Preventive therapy;Process;programs;Reporting;Research;Resource-limited setting;Rural;rural area;rural health clinic;rural South Africa;scale up;screening;Site;South Africa;South African;success;System;system-level barriers;Systems Analysis;testing access;Thoracic Radiography;tool;Translating;treatment guidelines;Tuberculosis;Tuberculosis diagnosis;tuberculosis treatment;Update;uptake;Viral;Visit;Work

PROJECT_TITLE: SAIA-TB: Using the Systems Analysis and Improvement Approach (SAIA) to prevent TB in rural South Africa


ORG_CITY: NEW YORK

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: We propose a Tri-Institutional Tuberculosis (TB) Research Advancement Center (TRAC) at Weill Cornell Medicine, Memorial Sloan-Kettering Cancer Center and Rockefeller University which are adjacent to each other in New York City. The purpose of the proposed Tri-I TRAC is to pool the expertise and resources of an outstanding team of 20 senior TB investigators at the three institutions to expand the number of investigators in the field of TB research and to promote innovative multidisciplinary TB research.

PI_NAMEs: FITZGERALD, DANIEL W (contact);RHEE, KYU Y

PROGRAM_OFFICER_NAME: MENDEZ, SUSANA

PROJECT_TERMS: Address;Animal Model;Area;Award;Basic Science;biobank;Biochemistry;career;Clinical;Clinical Research;clinical research site;Clinical Sciences;Clinical Trials;Collaborations;Communication;Development;Discipline;drug discovery;Educational workshop;Environment;experience;Faculty;Fostering;Funding;Gene Modified;Genetic;Goals;Haiti;Human Genetics;Immunology;implementation science;improved;innovation;Institution;Interdisciplinary Study;International;Leadership;Libraries;Maps;Medicine;member;Memorial Sloan-Kettering Cancer Center;Mentorship;Microbiology;Morbidity - disease rate;mortality;multidisciplinary;mycobacterial;National Institute of Allergy and Infectious Disease;New York City;organizational structure;Postdoctoral Fellow;Prevention;Program Evaluation;programs;recruit;Research;Research Personnel;Research Priority;Research Project Grants;Research Training;Resources;Sampling;Science;Scientist;Site;Strategic Planning;Structure;symposium;Tanzania;Technical Expertise;Technology;Translational Research;Travel;Tuberculosis;tuberculosis diagnostics;Underrepresented Minority;United States National Institutes of Health;Universities;Woman

PROJECT_TITLE: Tri-Institutional Tuberculosis Research Advancement Center (TRAC)


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Pediatric;Pediatric Cancer;Prevention;Primary Health Care;Rare Diseases;Social Determinants of Health

ORG_CITY: DURHAM

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE The burden of cancer among children disproportionally affects low- and middle-income countries, which accounts for over 80% of global childhood cancer cases and deaths. One of the main reasons impacting these poor outcomes is the lack of a strong health system, which impacts timely access to care along the care continuum, including timely diagnoses, referrals, and reaching care. The purpose of this project is to identify barriers and facilitators to access to cancer care for children in Tanzania and design a tailored intervention through implementation science methods.

PI_NAMEs: SMITH, EMILY  (contact)

PROGRAM_OFFICER_NAME: LEVINTOVA, MARYA

PROJECT_TERMS: Accounting;Address;Affect;Award;Cancer Burden;cancer care;cancer diagnosis;career;Caring;Cessation of life;Child;Child Care;Child Health;Child health care;child health care service;clinical care;clinical infrastructure;clinical practice;Clinical Trials Design;Communities;Community Actions;Competence;Complement;Comprehensive Health Care;Consolidated Framework for Implementation Research;Continuity of Patient Care;Country;Data;design;Diagnosis;diagnosis quality;Diagnostic;Disease;Ensure;epidemiologic data;Epidemiologist;Epidemiology;evidence base;Evidence based intervention;experience;Family;Foundations;Geography;global health;Goals;Grant;Health;Health Benefit;Health Services Accessibility;Health Services Research;Health system;Hospital Referrals;Hospitals;Human Resources;implementation research;implementation science;Improve Access;improved;improved outcome;Income;Infrastructure;interest;Intervention;intervention mapping;Interview;Leadership;Literature;low and middle-income countries;Low income;Malignant Childhood Neoplasm;Malignant Neoplasms;Maps;Measures;Medical center;member;Mentors;Mentorship;Methods;mortality;neoplasm registry;Newly Diagnosed;Oncology;Operative Surgical Procedures;Outcome;Pattern;Policy Maker;Process;programs;Provider;Proxy;Research;Research Infrastructure;Research Methodology;Research Personnel;Resources;Science;skill acquisition;skills;success;Surveys;Tanzania;Testing;therapy development;Training;Translating;Work;World Health Organization

PROJECT_TITLE: Improving access to cancer care for children in Tanzania: Designing a health-systems intervention

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ICP-G(55)R]


ORG_CITY: BALTIMORE

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: We have found that intra-arterial route seems to be very effective in delivery of antibodies to the brain and here we propose to perform mechanistic studies focused on better understanding of the process of antibody extravasation, which will provide a key knowledge toward widespread implementation of this technique to clinical setting.

PI_NAMEs: JANOWSKI, MIROSLAW  (contact)

PROGRAM_OFFICER_NAME: HEWETT, SANDRA JEANNE

PROJECT_TERMS: Address;Adoption;Animal Model;Antibodies;Binding;Biodistribution;Biotechnology;Blood;Blood - brain barrier anatomy;Brain;Brain Neoplasms;Catheters;Central Nervous System;Central Nervous System Diseases;Cerebrovascular system;Cerebrum;chelation;Chronic;Clinical;clinical translation;Country;Cyclotrons;Data;Dependence;Deposition;design;Disease;Distal;Dose;Drug Kinetics;Extravasation;Goals;Guidelines;Half-Life;Healthcare;Image;image guided;improved;Infusion procedures;Injections;insight;Intra-Arterial Infusions;Intra-Arterial Injections;Intravenous;intravenous administration;intravenous injection;Intuition;Knowledge;Learning;macromolecule;Magnetic Resonance Imaging;Malignant neoplasm of brain;Methodology;Modeling;Molecular Target;Mus;Neurologic;Oncology;Osmosis;Patients;Penetration;Perfusion;Pharmaceutical Preparations;Plasma;Play;Positioning Attribute;Positron-Emission Tomography;prevent;procedure safety;Procedures;Process;Production;protective effect;Proteomics;Radioimmunoconjugate;Radioisotopes;Radiolabeled;Reporting;response;Role;Route;Safety;safety study;Site;small molecule;Specificity;stem cells;Suspensions;Techniques;Technology;Testing;Therapeutic;Therapeutic Agents;Therapeutic antibodies;Therapeutic procedure;therapy outcome;Thrombosis;Time;Titrations;transcriptomics;treatment choice;uptake;Validation

PROJECT_TITLE: Image-guided, intra-arterial delivery of antibodies to the central nervous system

STUDY_SECTION: IPCA

STUDY_SECTION_NAME: Imaging Probes and Contrast Agents Study Section[IPCA]


ADMINISTERING_IC: CA

ED_INST_TYPE: HOSPITALS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Cancer;Hematology;Orphan Drug;Patient Safety;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_CITY: HOUSTON

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: Narrative The goal of this proposal is to develop statistical methods to compare different treatment options for patients with chronic myeloid leukemia (CML), to decide whether or not to receive a stem cell transplant, and if yes, what is the best time to receive it. Many different chronic diseases like CML have multiple treatment options, with some of them being aggressive and others mild. Our methods and software are widely applicable to them for conducting individual risk predictions, as well as optimizing treatment decisions for these patients to maximally prolong their survival, which will be validated through our proposed application to a study for chronic kidney disease.

PI_NAMEs: HUANG, XUELIN  (contact)

PROGRAM_OFFICER_NAME: CHEN, HUANN-SHENG

PROJECT_TERMS: Accounting;aggressive therapy;Benefits and Risks;Biological Markers;Cessation of life;Chronic Disease;Chronic Kidney Failure;Chronic Myeloid Leukemia;Computer software;Data;Decision Making;design;Development;Diabetes Mellitus;dimension reduction;Disease;Disease Progression;flexibility;follow-up;frailty;Future;Goals;graft vs host disease;Health Status;Heart Diseases;high dimensionality;improved;Individual;Kidney Diseases;leukemia;Life;Literature;Malignant Neoplasms;Mean Survival Times;Measurement;Methods;Modeling;Monitor;optimal treatments;Patient risk;Patients;Pattern;Performance;Physicians;Population;predictive modeling;Principal Component Analysis;Process;prognostic model;programs;Randomized, Controlled Trials;Research;Risk;Risk Estimate;risk prediction;Selection for Treatments;Series;simulation;software development;Statistical Methods;Statistical Models;Stem cell transplant;Techniques;temporal measurement;Testing;Time;treatment optimization;treatment strategy;user-friendly;validation studies;vector;virtual;virtual patient;Visit;Weight

PROJECT_TITLE: Optimizing treatment decision by accounting for longitudinal biomarker trajectories and competing risks of each individual

STUDY_SECTION: ASPB

STUDY_SECTION_NAME: Analytics and Statistics for Population Research Panel B Study Section[ASPB]


NIH_SPENDING_CATS: Neurosciences;Physical Injury - Accidents and Adverse Effects;Spinal Cord Injury;Traumatic Head and Spine Injury;Urologic Diseases

ORG_CITY: PITTSBURGH

ORG_DEPT: UROLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project narrative Both guarding and micturition reflexes require coordination of the bladder (BL) and external urethral sphincter (EUS) muscles, which is mediated by neural circuits in the brain and spinal cord. After complete spinal cord injury (SCI) voluntary control over micturition is eliminated. Recovery is possible if L4/L3 segments are not damaged, but suppression of the EUS guarding reflex is incomplete leading to detrusor-sphincter-dyssynergy (DSD) and inefficient voiding after SCI. Various therapeutic approaches have been employed to reduce DSD, but currently available treatments do not give fully satisfactory results and may be accompanied by side effects. Furthermore, sexual dimorphism in anatomy and function of the lower urinary tract (LUT) suggests differences in the spinal neural circuits of male and female which in turn may require different approaches to DSD treatment in males and females. Therefore, development of targeted DSD treatment requires better understanding of neural control and intimate mechanisms of intraspinal regulation of EUS and BL activity, which will help to design future therapeutic methods. This project is aiming to fill the gap in knowledge about the spinal circuit responsible for EUS relaxation during voiding and about the post-SCI involvement of a recently discovered LUT- related propriospinal circuit. New knowledge about sex-related differences in structure and function of these circuits in spinal intact (SI) and SCI animals will reveal critical points in gender- oriented therapies to cure LUT dysfunctions.

PI_NAMEs: KARNUP, SERGEI V;YOSHIMURA, NAOKI  (contact)

PROGRAM_OFFICER_NAME: MULLINS, CHRISTOPHER V

PROJECT_TERMS: 3-Dimensional;Anatomy;Anesthesia procedures;Animals;Area;Ataxia;Axon;biocytin;Bladder;Brain;C57BL/10 Mouse;Cell Nucleus;cholinergic neuron;Chronic;clinical practice;design;Development;efficacy evaluation;Electric Stimulation;Electrophysiology (science);excitatory neuron;Exhibits;experimental study;Feedback;Female;Functional disorder;Future;Gender;gender difference;Generations;Genetic;Glutamates;Goals;Horns;improved;In Vitro;in vivo;inhibitory neuron;Injections;injury recovery;insight;Interneurons;Interruption;intravesical;Knowledge;Label;Light;Lower urinary tract;mad itch virus;male;Mammals;Maps;Mediating;Methods;Micturition Reflex;Modification;Motor Neurons;mouse model;Mus;Muscle;neural;neural circuit;neuronal circuitry;Neurons;neuroregulation;Neurotransmitters;novel therapeutics;Optics;optogenetics;Pathway interactions;Periodicity;Persons;pharmacologic;Pontine structure;Population;postsynaptic;Preparation;pressure;Rattus;Reaction;Recommendation;Recovery;Recovery of Function;Recurrence;Reflex action;Regulation;Relaxation;Research Project Grants;Residual state;response;restoration;Rhodopsin;Role;sex;Sex Differences;sexual dimorphism;side effect;Slice;Sphincter;Spinal;Spinal Cord;Spinal Cord Diseases;Spinal cord injury;spinal pathway;spinal tract;Structure;Synapses;Synaptic Potentials;synergism;Techniques;Testing;Therapeutic;Therapeutic Intervention;therapeutically effective;Tracer;Transgenic Mice;Urethane;Urethral sphincter;Urinary Retention;Urination;Urine;urologic;Viral

PROJECT_TITLE: Intraspinal circuits supporting synergy between the bladder and urethral sphincter in mice

STUDY_SECTION: KUFD

STUDY_SECTION_NAME: Kidney and Urological Systems Function and Dysfunction Study Section[KUFD]


NIH_SPENDING_CATS: Aging;Arthritis;Osteoarthritis;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: PHILADELPHIA

ORG_DEPT: ORTHOPEDICS

ORG_NAME: THOMAS JEFFERSON UNIVERSITY

PHR: PROJECT NARRATIVE As people age they lose the ability to heal from injuries or diseases like osteoarthritis, partially due to a reduced ability of old stem cells to differentiate and an inhospitable tissue environment that no longer supports repair. To address this, we propose to 1) activate SIRT6, a sirtuin that can epigenetically reverse age-associated changes in stem cells and 2) inhibit apoptosis signal regulating kinase 1 (ASK1), a protein associated with cell death and inflammation, in the tissue environment. We will test the ability of this novel dual strategy to enhance stem cell differentiation and promote a more regenerative tissue environment in articular cartilage defect models of aged animals.

PI_NAMEs: COLLINS, JOHN A (contact)

PROGRAM_OFFICER_NAME: WILLIAMS, JOHN

PROJECT_TERMS: 3-Dimensional;Address;adult stem cell;Age;age related;age related changes;age related decline;age-related disease;aged;Aging;aging population;aging related;Animal Model;animal old age;Animals;anti aging;Anti-Inflammatory Agents;articular cartilage;Autologous;Body System;Cartilage;cartilage degradation;cartilage regeneration;cartilage repair;cell age;Cell Death;cell motility;Cells;Chondrocytes;Chondrogenesis;clinical translation;clinically relevant;Coculture Techniques;cytokine;Data;Defect;Degenerative polyarthritis;Disease;Disease Progression;efficacy evaluation;Environment;Epigenetic Process;epigenetic regulation;Event;Failure;Family suidae;Female;Genes;Genetic;healing;Histology;Hydrogels;Immune;In Vitro;in vivo;Inflammation;Inflammatory;Inhibition of Apoptosis;inhibitor;Injections;Injury;innovation;insight;Intervention;joint injury;Joints;Life;Macrophage;male;MAP3K5 gene;matrigel;microCT;Miniature Swine;Modeling;Mus;novel;novel strategies;old mice;Oral;Osteogenesis;Oxidative Stress;Persons;pharmacologic;pre-clinical;prevent;Probability;Production;Proliferating;Proteins;Publishing;Rattus;regenerative;regenerative repair;regenerative therapy;regenerative tissue;Rejuvenation;repaired;response;Risk Factors;Rodent;Rodent Model;Role;Signal Transduction;Sirtuins;Site;Spectroscopy, Fourier Transform Infrared;stem cell differentiation;stem cell exhaustion;stem cell population;stem cell therapy;stem cells;stress kinase;Testing;Thick;tissue culture;Tissues;translational potential

PROJECT_TITLE: Promoting regenerative repair of aged cartilage

STUDY_SECTION: SBSR

STUDY_SECTION_NAME: Skeletal Biology Structure and Regeneration Study Section[SBSR]


NIH_SPENDING_CATS: Brain Disorders;Genetics;Human Fetal Tissue;Neurosciences;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: SAN FRANCISCO

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative We seek to understand the mechanisms underlying timing of developmental events in the cerebral cortex. Our approach leverages unbiased single cell sequencing resources and innovative technologies for studying developmental lineage relationships to study the timing and mechanisms underlying the onset of astrogliogenesis in the cerebral cortex. If successfully, this project will provide understanding of when and where distinct subtypes of human astrocyte emerge, establishing a framework and identify experimental model system for studying the developmental mechanisms underlying astrocyte subtype specification from cortical progenitor cells.

PI_NAMEs: NOWAKOWSKI, TOMASZ  (contact)

PROGRAM_OFFICER_NAME: LAVAUTE, TIMOTHY M

PROJECT_TERMS: Address;Adult;Anatomy;Area;Astrocytes;Bar Codes;Biological Models;Brain;brain tissue;Categories;cell cortex;Cell Differentiation process;cell fate specification;Cell Lineage;cell type;Cells;Cerebral cortex;Characteristics;Classification;Comparative Study;Competence;CRISPR/Cas technology;Data;Development;developmental neurobiology;DNA Sequence Alteration;Event;Experimental Models;experimental study;Ferrets;Fiber;Gene Expression;Generations;Genes;Genetic;Goals;Grant;Heterogeneity;Human;human stem cells;human tissue;in silico;in vivo;Individual;innovation;innovative technologies;knock-down;Knowledge;Maps;Mental disorders;Methods;Modeling;Molecular;molecular marker;molecular subtypes;Morphology;Mus;Mutation;neonatal brain;neonatal mice;nerve stem cell;Neurodevelopmental Disorder;neuroepithelium;Neuroglia;Neurons;Newborn Infant;Oligodendroglia;Pathway interactions;Pattern;Phenotype;postmitotic;Pregnancy;Primates;Production;progenitor;Protoplasmic Astrocyte;Radial;Resources;Rodent;Second Pregnancy Trimester;segregation;Series;single cell mRNA sequencing;single cell sequencing;Slice;Specific qualifier value;stem cell differentiation;stem cells;subventricular zone;Swelling;TCF7L2 gene;Technology;Testing;Time;tool;transcription factor;transcriptomics;Transplantation;Ventricular;Viral;Work;Xenograft procedure;ZIKV infection

PROJECT_TITLE: Developmental Timing During Cortical Development

STUDY_SECTION: NCF

STUDY_SECTION_NAME: Neurogenesis and Cell Fate Study Section[NCF]


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Digestive Diseases;Dissemination and Implementation Research;Health Services;Rehabilitation

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE Chronic constipation affects 10-20% of the population and leads to 2 million gastroenterology referrals each year in the US. We will apply behavioral economics, user-centered design, and implementation science to develop a novel clinical care pathway to rapidly triage patients to effective and targeted therapy for constipation using a recently validated point-of-care diagnostic device. This work will allow more patients to receive efficient and appropriate care and will help patients avoid unnecessary tests and repeated trials of ineffective and costly laxatives.

PI_NAMEs: SHAH, ERIC DINESH (contact)

PROGRAM_OFFICER_NAME: OSGANIAN, VOULA

PROJECT_TERMS: Academic Medical Centers;Adoption;Affect;Automobile Driving;behavioral economics;career;Caring;Chronic;Chronic Care;Clinic;Clinical;clinical care;clinical decision support;clinical practice;Colonoscopy;Community Practice;Constipation;Consultations;cost;Data;design;Devices;Diagnostic Equipment;Diagnostic Procedure;diagnostic technologies;Disease;effective therapy;Effectiveness;Electronic Health Record;Endoscopy;evidence base;Fiber;Funding;Gastroenterologist;Gastroenterology;Gastrointestinal Motility;Goals;Grant;Guidelines;Health;health care delivery;Health system;Image;Impairment;implementation science;implementation trial;Improve Access;improved;Intake;Intervention;laxative;learned behavior;Medical;medical specialties;Motility;motility disorder;Multicenter Trials;Needs Assessment;novel;Outpatients;Pathway interactions;Patient Care;patient population;Patient Triage;Patients;Pelvic floor structure;Pelvis;physical therapist;Physical therapy;Physiological;pilot trial;point of care;Point of Care Technology;point-of-care diagnostics;Population;Positioning Attribute;Positive Reinforcements;Practice Guidelines;practice setting;Prediction of Response to Therapy;Process;Production;prospective;Provider;provider adoption;provider behavior;Quality of life;Questionnaires;randomized trial;Recommendation;Rectum;Refractory;Rehabilitation therapy;Research;Research Personnel;response;Rotation;routine care;Specialized Center;success;support tools;Symptoms;targeted treatment;Technology;technology development;tertiary care;Testing;Training;treatment as usual;Treatment outcome;Triage;United States National Institutes of Health;usability;user centered design;Visit;Work

PROJECT_TITLE: Guideline to Implementation: A Rapid Clinical Care Pathway to Care for Patients Affected by Chronic Constipation

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


NIH_SPENDING_CATS: Genetics

ORG_CITY: NEW ORLEANS

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: PROJECT NARRATIVE Identifying the genetic basis of complex traits that affect survival and reproduction in natural populations can have important implications for human health since most diseases are genetically complex. Pinpointing individual genes responsible for variation in complex phenotypes and linking that variation to fitness in natural populations is more easily accomplished in short lived, sessile organisms than in human populations. We propose to use manipulative genetic and ecological field studies to causally link genes to variation in complex traits and fitness in natural populations of yellow Monkeyflowers, an emerging ecological genomic system. !

PI_NAMEs: FERRIS, KATHLEEN GRAY (contact)

PROGRAM_OFFICER_NAME: ADKINS, RONALD

PROJECT_TERMS: Address;Affect;Agriculture;Animals;Biology;Candidate Disease Gene;climate change;Complex;Disease;Environment;Evolution;field study;fitness;Generations;Genes;Genetic;genetic architecture;Genetic study;Genetic Variation;genome wide association study;genomic tools;Genomics;Genotype;Goals;Habitats;Health;Human;human disease;Hybrids;Individual;Link;Maps;Mimulus;Molecular;Morphology;Organism;Partner in relationship;Phenotype;Plants;Polygenic Traits;Population;Quantitative Trait Loci;Recombinants;Reproduction;Resolution;Scanning;System;Testing;Time;trait;Transplantation;Variant;Work

PROJECT_TITLE: The genetic basis and adaptive significance of divergence in quantitative traits in sympatric Mimulus species

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-D(55)R]


NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: BOSTON

ORG_NAME: HARVARD MEDICAL SCHOOL

ORG_STATE: MA

PHR: The transcription factor FoxP3 plays a key role in the differentiation and activity of T regulatory cells, which protect against autoimmune disease and immunopathology. Our recent analysis of FOXP3-deficient IPEX patients and mice brought novel insight on the mechanisms of this disease, and on molecular aspects of FOXP3 function. We will build on this foundation and dissect the molecular and functional defects of FOXP3 revealed by these mutations, furthering our understanding of IPEX disease and its determining factors, and providing molecular details on this mysterious but essential transcription factor.

PI_NAMEs: BENOIST, CHRISTOPHE O. (contact)

PROGRAM_OFFICER_NAME: JIANG, CHAO

PROJECT_TERMS: 3-Dimensional;Affect;Alanine;Appearance;Architecture;ATAC-seq;Australia;Autoimmune;Autoimmune Diseases;Autoimmunity;Back;Boston;CD4 Positive T Lymphocytes;Cell Nucleus;Cell Physiology;Cells;Characteristics;Chromatin;Chromatin Structure;Clinical;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;cofactor;Colitis;Collaborations;Complex;conditioning;Controlled Environment;Cytometry;Data;Defect;Dermatitis;Disease;Engineering;Enhancers;Environment;Family;Female;forkhead protein;Foundations;FOXP3 gene;Functional disorder;Gene Expression;Gene Expression Profile;Genes;Genetic;Genetic Transcription;Genomics;Germ Lines;Grant;Heterozygote;Homeostasis;Human;Immune Tolerance;Immunologics;immunopathology;immunoregulation;in vivo;Inflammation;insight;Internal Ribosome Entry Site;Italy;Learning;Lesion;Link;Location;Lymphoid;male;Maps;Mediator;Microbe;microbial;Missense Mutation;Modeling;Molecular;Mothers;multiple omics;Mus;mutant;Mutant Strains Mice;Mutation;novel;Nuclear;Nuclear Structure;Organ;Organism;Paris, France;pathobiont;Pathology;Patients;Phenotype;Play;Predisposition;programs;promoter;Proteins;Recording of previous events;Regulation;Regulatory T-Lymphocyte;Reporter;Repression;Resolution;response;Sampling;Scanning;Severities;single-cell RNA sequencing;Specific qualifier value;Structure;superresolution microscopy;symptomatology;Symptoms;T-Lymphocyte;Testing;Tissues;transcription factor;transcriptome;transcriptome sequencing;transcriptomics;United States National Institutes of Health;Variant;Work

PROJECT_TITLE: Specification of Treg cells: learning from FoxP3 deficiencies

STUDY_SECTION: CMIA

STUDY_SECTION_NAME: Cellular and Molecular Immunology - A Study Section[CMIA]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Cocaine;Drug Abuse (NIDA only);Neurosciences;Opioids;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: GAINESVILLE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE  There is an urgent unmet medical need for pharmacological treatments for cocaine use disorder. Novel compounds that block kappa opioid receptor activity will be synthesized, characterized and studied with the goal of identifying novel treatments for cocaine use disorder that can be advanced into development for potential clinical trials.

PI_NAMEs: ALDRICH, JANE V (contact);BIDLACK, JEAN M;MCLAUGHLIN, JAY P.

PROGRAM_OFFICER_NAME: CYWIN, CHARLES L

PROJECT_TERMS: ABCB1 gene;Acute;Affinity;Agonist;analog;Animal Model;antagonist;Behavior;Behavioral;Behavioral Assay;Binding Proteins;Biological Assay;blood-brain barrier crossing;Caco-2 Cells;candidate identification;Cell model;Cells;Chemosensitization;Chronic;Chronic Disease;clinical development;Clinical Trials;Cocaine;cocaine craving;cocaine reward;cocaine seeking;cocaine use;Cocaine use disorder;conditioned place preference;Cyclic Peptides;Data;design;Development;Disease;drug craving;drug discovery;Drug Kinetics;Drug Modulation;drug reward;Drug usage;Dynorphins;Evaluation;Exposure to;Generations;Goals;improved;In Vitro;in vitro activity;in vivo;in vivo evaluation;Individual;Intravenous;kappa opioid receptors;Lead;lead optimization;Ligands;Liver;Medical;Metabolism;mimetics;Modeling;Modification;monolayer;mouse model;Mus;Neurosciences;novel;novel therapeutics;Opioid;Opioid Antagonist;Opioid Receptor;Opioid Receptor Binding;Oral;Oral Administration;Overdose;Patients;Peptides;Permeability;Persons;pharmacologic;Pharmacological Treatment;Pharmacology;Phase;Plasma Proteins;Positioning Attribute;preclinical evaluation;Preparation;prevent;Property;Receptor Activation;Relapse;relapse prediction;Reporting;Research;Research Personnel;Rodent Model;safety study;Self Administration;Stress;Structure-Activity Relationship;success;Testing;Therapeutic;Treatment Efficacy;Work

PROJECT_TITLE: Cyclic Peptides to Treat Cocaine Use Disorder


NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Drug Abuse (NIDA only);Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Substance Misuse

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: PROJECT NARRATIVE The proposed research aims to dynamically advance understanding of American Indian (AI) culture as protective against substance use, inform future substance use interventions, lend to efforts to promote insurance coverage for traditional healing, and guide theoretical frameworks of AI health. This work will be guided by Community-based Participatory Research to 1) codify community conceptualization of one AI ceremony and its protective functions relevant to substance use; 2a) determine how cultural engagement through this ceremony confers protection against substance use; 2b) develop a menu of strategies to support community implementation of one AI ceremony; and 3) examine the neurocognitive correlates of the ceremony and associated stimuli relevant to substance use.

PI_NAMEs: GONZALEZ, MIIGIS B (contact)

PROGRAM_OFFICER_NAME: ROMBERG, ALEXA RUTH

PROJECT_TERMS: Abstinence;Adult;Affect;alcohol and other drug;American Indian community;American Indians;Behavior;Belief;Buffers;Caring;Chippewa;Chronic;Cognitive;cognitive control;Communities;community based participatory approach;community based participatory research;community engagement;community partners;comorbidity;Conceptions;Control Groups;depressive symptoms;design;Discipline;Drug usage;Elderly;Enrollment;Equity;Event;Family;Fasting;follow-up;Food;Funding;Future;Goals;Grief reaction;healing;Health;Health Services;High Prevalence;implementation science;implementation strategy;improved;Indigenous;Inequity;Insurance Coverage;intergenerational;Intervention;Knowledge;Leadership;life span;Measurement;Mediating;Medicine;member;Mental disorders;Methodology;Methods;mindfulness;Modeling;neural;Neurocognitive;Neurologic;Outcome;Personal Satisfaction;Policies;Prayers;Prevention;Process;protective factors;Protocols documentation;psychosocial;Randomized;Randomized, Controlled Trials;reduced substance use;Religion;Research;response;Rest;Risk;Risk Factors;Role;Sampling;Severities;Social Work;Spirituality;State Government;Stimulus;Structure;substance use;Substance Use Disorder;Tobacco;transmission process;Trauma;United States;Waiting Lists;Work

PROJECT_TITLE: The Protective Role of Ceremony Against Substance Use for American Indian Adults

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 SCIL-P (55)]


ORG_CITY: CINCINNATI

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF CINCINNATI

ORG_STATE: OH

PHR: PROJECT NARRATIVE The crosstalk of organelles including fusion and contact is involved in different stages of autophagy. SNAREs, vacuolar protein sorting-associated protein 33A, and Atg9 play a critical role in regulating the crosstalk of organelles, which is essential for autophagosome biogenesis.

PI_NAMEs: DIAO, JIAJIE  (contact)

PROGRAM_OFFICER_NAME: STOKES, KALYNDA K

PROJECT_TERMS: Autophagocytosis;Autophagosome;Biochemical;Biogenesis;Biological;Biological Assay;Biophysics;Cells;Data;Development;Diabetes Mellitus;Disease;drug development;Functional disorder;Future;Human;human disease;In Vitro;Investigation;life span;Malignant Neoplasms;Molecular;Neurodegenerative Disorders;novel therapeutic intervention;optogenetics;Organelles;Pathway interactions;Play;Process;protein reconstitution;Proteins;Quality Control;Recycling;response;Role;SNAP receptor;Stress;superresolution imaging;System;target SNARE proteins;Therapeutic;tool;Vacuolar Protein Sorting;Vesicle;wasting

PROJECT_TITLE: The crosstalk of organelles involved in autophagosome biogenesis

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Biotechnology

ORG_CITY: COLLEGE PARK

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

PHR: Project Narrative: The premise of this project is that acyclic CB[n] – with their high binding affinity, straightforward synthesis, and outstanding biocompatibility – are ideally suited for development as in vivo sequestration agents for toxic substances from the gut and the bloodstream, as (targeted) drug delivery agents, as components of sensing ensembles, and as model systems for the SAMPL challenges. We propose to systematically vary the structural features of acyclic CB[n]-type receptors, study their molecular recognition properties in buffered water toward selected drugs / toxic substances, and engage with chemical and biological collaborators to demonstrate their utility in biomedical applications.

PI_NAMEs: ISAACS, LYLE D (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TERMS: Affinity;American Association for the Advancement of Science;Antibodies;aqueous;Binding;Biological;Biological Models;biomaterial compatibility;Blinded;Blood Circulation;Buffers;career;Cessation of life;Chemicals;Chemistry;Collaborations;college;community building;Complex;computational chemistry;Data Set;design;Development;Disease;Doctor of Philosophy;Drug Delivery Systems;Drug Kinetics;Event;Exhibits;Faculty;faculty mentor;Feedback;Fellowship Program;Free Energy;glycoluril;Goals;Graduate Education;High School Student;Illicit Drugs;in vivo;International;Journals;Leadership;Maryland;meetings;Methods;Molecular;molecular recognition;Nature;Peer Review;Pharmaceutical Chemistry;Pharmaceutical Preparations;Pharmacodynamics;Poison;Positioning Attribute;Postdoctoral Fellow;Prize;professor;programs;Property;Proteins;receptor;Research;Running;Series;Services;small molecule inhibitor;Societies;Solubility;Structure;symposium;Toxin;Training;undergraduate student;United States National Institutes of Health;Universities;Vision;Washington;Water

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BBBT-H (56)]


NIH_SPENDING_CATS: Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_NAME: NORTH CAROLINA CENTRAL UNIVERSITY

PHR: 8. Project Narrative Two human herpesviruses, Epstein- Barr virus (EBV) and Kaposi’s sarcoma herpesvirus (KSHV/HHV8) are known to cause several human cancers. Effective antiviral therapeutics are needed for the treatment of KSHV infection. By using specialized electron microscopy (EM) to directly visualize protein-DNA structures and protein- protein conformations our goal is to identify novel anti-viral targets.

PI_NAMEs: COSTANTINI, LINDSEY M (contact)

PROGRAM_OFFICER_NAME: CUPIT, PAULINE

PROJECT_TERMS: Address;Amino Acid Sequence Homology;Anti-viral Agents;Antibody Formation;Architecture;Binding;Binding Proteins;Binding Sites;Biochemical;Biological;Biology;Cell Culture System;Cell Culture Techniques;Cell Line;Cell Physiology;cell type;Cells;Data;Data Set;dimer;DNA;DNA Binding;DNA biosynthesis;DNA mapping;DNA Structure;DNA-Directed DNA Polymerase;DNA-Protein Interaction;effective therapy;Electron Microscopy;Engineering;Exhibits;Foundations;Future;gammaherpesvirus;Gel;Genes;Genetic Transcription;Genome;Goals;graduate student;helicase;Herpesviridae;Heterogeneity;HIV;HIV Envelope Protein gp120;Human;Human Cell Line;Human Herpesvirus 4;Human Herpesvirus 8;In Vitro;in vitro activity;Individual;Infection;inhibitor;Insect Proteins;Insecta;insight;Knowledge;Learning;Legal patent;Location;Lytic;Malignant Neoplasms;Mammalian Cell;manufacture;Methodology;Methods;Modeling;Modification;Molecular;Molecular Biology;Molecular Conformation;molecular size;monomer;mutant;new therapeutic target;novel;novel therapeutics;Nucleotides;Physiological;Positioning Attribute;Post-Translational Protein Processing;preservation;prevent;Production;Productivity;protein complex;Protein Conformation;protein expression;protein function;protein purification;Proteins;Publications;Publishing;reconstitution;Replication Initiation;Replication Origin;Research;Sequence Homology;single molecule;System;Techniques;Technology;therapeutic target;Translational Protein Modification;Translations;undergraduate student;Vaccines;vector;Viral;viral DNA;Viral Proteins;Virus;Virus Diseases;Virus Replication;Visualization;Work

PROJECT_TITLE: Single Molecule analysis of KSHV/HHV8 DNA replication proteins

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 RCB-X (SU)]


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Digestive Diseases;Immunotherapy;Liver Disease;Organ Transplantation;Precision Medicine;Prevention;Transplantation

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative The objective of this proposal is to design a randomized clinical trial to test whether a non- invasive miRNA rejection profile can guide lowering immunosuppression in liver transplant recipients, and that reducing immunosuppression is not associated with rejection.

PI_NAMEs: SHAKED, ABRAHAM NA (contact)

PROGRAM_OFFICER_NAME: HAYES, DEBORAH

PROJECT_TERMS: Acute;Allografting;arm;B-Lymphocytes;biobank;Biological Assay;Biological Markers;Biology;CD8B1 gene;cell determination;cell type;Cells;cholangiocyte;Clinical;Clinical Protocols;Clinical Research;Clinical Trials;Clinical Trials Data Monitoring Committees;Clinical Trials Design;Consent Forms;Data;Data Analyses;Data Collection;data management;Data Management Resources;design;Development;Diagnosis;Diagnostic;dosage;Dose;dynamic system;Early Diagnosis;Early identification;Enrollment;Ensure;Evaluation;Exhibits;Functional disorder;Hepatocyte;Immune;immune activation;Immune response;Immune Tolerance;Immunologic Markers;Immunosuppression;Immunosuppressive Agents;improved;Incidence;Inflammatory;Injury;insight;Institutional Review Boards;Intention;Light;Liver;liver injury;liver transplantation;Maintenance;Manuals;Mediating;Methods;Methylation;methylation pattern;MicroRNAs;Modification;Molecular;Monitor;monocyte;new technology;operation;Outcome;Outcome Assessment;Outcome Measure;Pathology;Pathway interactions;Patients;Personal Satisfaction;personalized management;personalized medicine;Pharmaceutical Preparations;Phase;phase 3 study;phase I trial;phase II trial;potential biomarker;predicting response;predictive marker;Preparation;prevent;Procedures;prognostic;prospective;Protocols documentation;Randomized;randomized trial;randomized, clinical trials;recruit;Reporting;Research Design;Research Personnel;response;Risk;Risk Reduction;Sampling;Serum;side effect;Site;Specimen;Statistical Data Interpretation;Technology;Testing;Therapeutic immunosuppression;Tissues;Training;Transplant Recipients;Transplantation;United States National Institutes of Health;Writing

PROJECT_TITLE: miRNA profiling for monitoring and adjustment of immunosuppression in liver transplant recipients

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 VSR-I (J1)]


NIH_SPENDING_CATS: Bioengineering;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

PHR: Project Narrative  The research supported by this award will develop new computational methods and tools for drug discovery so that novel therapeutics can be discovered more quickly and with less expense. The de- veloped methods will be evaluated prospectively in drug discovery projects of high relevance to human health. The resources developed will be readily accessible through open-access web sites and open-source software.

PI_NAMEs: KOES, DAVID RYAN (contact)

PROGRAM_OFFICER_NAME: GERSHENSON, ANNE

PROJECT_TERMS: 3-Dimensional;Acceleration;Actins;Address;Amino Acid Sequence;antiangiogenesis therapy;Area;Autoimmune Diseases;Award;Binding;Biological Assay;Biotechnology;candidate identification;career development;Chemicals;Chronic;Code;Commercial Catalogs;Computer software;computerized tools;Computing Methodologies;Data;deep learning;deep neural network;Development;Development Plans;Diabetic Retinopathy;Differential Equation;Disease;Docking;Drug Design;drug discovery;Evaluation;Event;Evolution;Feedback;Generations;generative models;Goals;Health;Human;improved;inhibitor;innovation;Knowledge;large language model;Lead;lead candidate;lead optimization;Leadership;Learning;Libraries;Ligands;Malignant Neoplasms;meetings;method development;Methods;Minority;Modeling;Molecular;molecular dynamics;Molecular Structure;Molecular Target;Motion;Neural Network Simulation;novel;novel therapeutics;open source;open source tool;Paper;parent grant;parent project;Parents;Pharmaceutical Preparations;Physiology;Positioning Attribute;Process;Productivity;profilin;Property;prospective;Protein Dynamics;protein function;protein structure;Proteins;Publications;Pythons;Recording of previous events;Research;research clinical testing;Research Support;Resources;Sampling;screening;simulation;skills;small molecule;Structure;success;System;Time;tool;Training;Training Support;Update;usability;user-friendly;Vacuum;virtual screening;web app;web site;Work;Writing

PROJECT_TITLE: New Methods and Tools for Computational Drug Discovery: Diversity Supplement

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(55)-R]


ORG_CITY: PORTLAND

ORG_DEPT: GENETICS

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

PHR: Project Narrative Ribosome biogenesis is essential for normal cell growth and proliferation. Its defects are associated with a group of human diseases called ribosomopathies. This study aims at elucidating the role and mechanism of the nucleolar SUMOylation and deSUMOylation dynamics regulated by USP36 SUMO ligase and SUMO protease SENP3 in ribosome biogenesis.

PI_NAMEs: DAI, MU-SHUI  (contact)

PROGRAM_OFFICER_NAME: VATAKIS, DIMITRIOS NIKOLAOS

PROJECT_TERMS: Address;Biogenesis;cell growth;Cell Nucleolus;Cell Physiology;Cell Proliferation;Cells;Complex;Defect;Disease;Dissection;endonuclease;exosome;Goals;Homeostasis;human disease;insight;Laboratories;Ligase;Mediating;Molecular Biology;molecular imaging;Normal Cell;novel;Nucleolar Proteins;Peptide Hydrolases;Play;Post-Translational Protein Processing;programs;Regulation;Research;response;Ribosomal RNA;Ribosomes;ribosomopathy;RNA;Role;Small Nucleolar Ribonucleoproteins;Stress;structural biology;Sumoylation Pathway;ubiquitin-specific protease;Work

PROJECT_TITLE: SUMOylation regulation of ribosome biogenesis


ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: PROJECT NARRATIVE Infectious bacteria are becoming more widespread and resistant to most existing antibiotics. Therefore, the study of how bacterial cells regulate their growth and division, a process essential for bacteria to colonize their host and proliferate, is relevant to public health because regulators of the cell wall synthesis machinery represent novel targets for new therapeutics.

PI_NAMEs: MARGOLIN, WILLIAM  (contact)

PROGRAM_OFFICER_NAME: MILLER, RITA K

PROJECT_TERMS: Actins;Antibiotics;Bacillus;Bacteria;Binding;biological adaptation to stress;Cell division;Cell Physiology;Cell Wall;Cells;cellular imaging;Chromosome Segregation;Cities;Collaborations;crosslink;Cytoskeletal Proteins;Escherichia coli;Genetic;Genetic Materials;Grant;Growth;In Vitro;in vivo;Infrastructure;insight;Investigation;L Forms;Licensing;Liquid substance;Maps;medical specialties;Membrane;Modeling;Molecular;Molecular Conformation;Molecular Genetics;molecular scale;nanomachine;new therapeutic target;novel;Phase;Physical condensation;Physiological;Polymers;Process;Proliferating;Protein Biochemistry;Protein Conformation;protein protein interaction;Proteins;Public Health;reconstitution;Regulation;Resistance;Structure;superresolution imaging;Time;tool;Tubulin;Variant;Visualization;Work

PROJECT_TITLE: Mechanisms and Regulation of Cell Division in Bacteria

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]