NIH_SPENDING_CATS: Aging;Osteoporosis;Pediatric

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Project Narrative Bone is highly vascularized. Chronic, high doses of glucocorticoids reduce bone vasculature, which is a unifying histologic feature of glucocorticoid-induced osteoporosis and osteonecrosis. Basic and translational research dissecting the mechanism how glucocorticoids impair bone vasculature will identify potential biomarkers and drug targets to diagnose and treat people with glucocorticoid-induced skeletal side effects.

PI_NAMEs: CRANE, JANET  (contact)

PROGRAM_OFFICER_NAME: NICKS, KRISTY

PROJECT_TERMS: Acute Pain;Adult;Affect;angiogenesis;Animal Model;Arthritis;Asthma;Basic Science;Binding;Blood;Blood capillaries;Blood flow;Blood Vessels;bone;Bone Growth;Bone necrosis;Cell Line;Cell Lineage;cell type;Cells;Child;Chronic;Chronic Obstructive Pulmonary Disease;chronic pain;Clinical;Deformity;Diagnosis;Distal;Dose;Drug Targeting;efficacy evaluation;Endothelium;Epiphysial cartilage;Exceptional Child;FDA approved;Femur;Functional disorder;Future;Genetic;Genetic Transcription;Glucocorticoid Receptor;Glucocorticoids;Graft Rejection;Growth;Health;Histologic;Hypersensitivity;Impairment;in vivo;Incidence;Inflammatory Bowel Diseases;insight;Knock-out;Knowledge;life span;long bone;Longevity;Lung Transplantation;Maintenance;Malignant Neoplasms;Mediating;Medical;Metabolic;Metaphysis;mouse model;Mus;Neck;NF-kappa B;Nutrient;Osteoblasts;Osteoclasts;Osteogenesis;Osteoporosis;overexpression;Patients;Persons;Pharmaceutical Preparations;Pharmacotherapy;Phenotype;Platelet-Derived Growth Factor;potential biomarker;precursor cell;prednisolone;Prevalence;prevent;promoter;recruit;Replacement Arthroplasty;Reporting;Role;Shunt Device;side effect;Signal Pathway;Signal Transduction;Site;skeletal;Skeleton;Speed;Steroids;targeted treatment;therapeutic development;Therapeutic Intervention;tibia;Tissues;Transgenic Mice;Translational Research;Tube;Up-Regulation;Vascularization;Vulnerable Populations;wasting;Wild Type Mouse;Work

PROJECT_TITLE: Role of glucocorticoid-suppression of preosteoclast PDGF-BB in skeletal angiogenesis

STUDY_SECTION: SBDD

STUDY_SECTION_NAME: Skeletal Biology Development and Disease Study Section[SBDD]


ADMINISTERING_IC: HL

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Lung;Sleep Research

ORG_CITY: NEW YORK

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: Narrative Obstructive sleep apnea (OSA), a condition that affects a quarter of American adults, triples the risk for cardiovascular diseases and increases all-cause mortality. Standard therapy with continuous positive airway pressure (CPAP) does not improve cardiovascular risk. Based on our mechanistic observation that the abnormal cycle of endothelial inflammation can be disrupted with statin therapy, we now propose randomized clinical trial of statins vs. placebo to determine its effects on endothelial dysfunction in OSA patients treated with CPAP, which may provide the basis for practical clinical trials of statins for reducing cardiovascular risk in OSA.

PI_NAMEs: JELIC, SANJA  (contact)

PROGRAM_OFFICER_NAME: LAPOSKY, AARON D

PROJECT_TERMS: Address;Adherence;Adult;Affect;Alternative Therapies;American;Angiogenic Factor;Angiopoietin-2;atorvastatin;Blood Vessels;cardiovascular disorder risk;cardiovascular risk factor;Cardiovascular system;Cell Adhesion;Cell Adhesion Molecules;Cell surface;Cholesterol;Cholesterol Homeostasis;cholesterol trafficking;Clinical Trials;cohort;Complement;Complement Inactivators;Complement Membrane Attack Complex;Continuous Positive Airway Pressure;Cytoplasmic Granules;Data;Deposition;Double-Blind Method;E-Selectin;Endoplasmic Reticulum;endoplasmic reticulum stress;Endothelial Cells;endothelial dysfunction;Endothelium;epithelial injury;Epithelium;Esterification;experience;glycoprotein 340;Harvest;Hypoxia;Impairment;improved;in vitro Model;Inflammation;Inflammatory;inflammatory marker;inflammatory milieu;Intercellular adhesion molecule 1;late endosome;Lipids;Lung;lung volume;Mechanical ventilation;Mediating;Membrane Proteins;Minority;Molecular;mortality;Newly Diagnosed;NF-kappa B;novel therapeutic intervention;Nuclear Translocation;Observational Study;Obstructive Sleep Apnea;Outcome;oxysterol binding protein;Patients;placebo controlled study;Placebos;Plasma;pressure;Process;protein B;Proteins;Pulmonary Surfactant-Associated Protein D;Random Allocation;Randomized;randomized placebo controlled trial;randomized trial;randomized, clinical trials;receptor for advanced glycation endproducts;Research Design;Residual state;response;Risk Factors;Running;Sampling;Sleep Apnea Syndromes;Sleep Fragmentations;Specific qualifier value;vascular endothelial dysfunction;vascular injury;vesicle-associated membrane protein;von Willebrand Factor;VWF gene;Weibel-Palade Bodies

PROJECT_TITLE: Vascular endothelial dysfunction in sleep apnea

STUDY_SECTION: CHSA

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology A Study Section[CHSA]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: LONG BEACH

ORG_NAME: VETERANS HEALTH ADMINISTRATION

ORG_STATE: CA

PHR: Notwithstanding recent success in immunotherapy, Merkel cell carcinoma (MCC) is often lethal, especially if not diagnosed and treated at an early stage. Moreover, MCC disproportionately affects Veterans and imposes a growing impact on Veteran healthcare. This project aims to ascertain a potential new therapeutic paradigm for advanced MCC in the emerging field of antibody-drug conjugates (ADCs). Leveraging our unique and highly clinically relevant biological resources, we are ideally positioned to determine the safety and efficacy of a novel ADC, m276-SL-PBD, and lend insights to biomarkers of response and resistance. Successful completion of proposed studies will validate and accelerate a therapeutic paradigm shift, helping Veterans and others who become resistant to immunotherapy, or to serve as definitive treatments for MCC patients who are ineligible for immunotherapy due to comorbidities.

PI_NAMEs: GAO, LING  (contact)

PROJECT_TERMS: Acceleration;advanced disease;Affect;anti-cancer;Antibodies;Antibody-drug conjugates;base;Biological;Biological Markers;Biology;biomarker identification;Blocking Antibodies;cancer cell;Cancer Model;cancer stem cell;cancer therapy;CAR T cell therapy;Caucasians;Cause of Death;CD276 gene;Cell Line;Certification;Clinical;Clinical Trials;clinically relevant;cohort;Collaborations;comorbidity;confirmatory clinical trial;cost effective;cost effectiveness;Couples;cytotoxic;Data;Death Rate;design;Diagnosis;DNA Binding Agent;drug discovery;efficacy evaluation;Endowment;established cell line;Evaluation;Fruit;Future;Health;Healthcare;Healthcare Systems;Human;human old age (65+);Immune;Immune system;Immunotherapy;Improve Access;in vivo;insight;Inter-tumoral heterogeneity;Investigation;male;Malignant Neoplasms;Medical center;Melanoma;Merkel cell carcinoma;Modeling;mouse model;Mus;National Cancer Institute;Neoplasm Metastasis;neuroendocrine cancer;novel;novel strategies;novel therapeutics;Outcome;overexpression;patient derived xenograft model;Patients;Pharmaceutical Preparations;Positioning Attribute;pre-clinical;Pre-Clinical Model;preclinical study;Prediction of Response to Therapy;prevent;Productivity;rare cancer;reconstitution;Reporting;Resistance;Resources;response;response biomarker;Role;Safety;Skin;Skin Cancer;Solid Neoplasm;Stromal Cells;Stromal Neoplasm;subcutaneous;success;Survival Rate;targeted treatment;Testing;Therapeutic;therapy resistant;Treatment Efficacy;treatment response;tumor;tumor microenvironment;Tumor-Derived;Up-Regulation;Veterans;Visceral;Work;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Unravel the role of CD276 and determine efficacy of CD276-targeted therapy on Merkel cell carcinoma progression and metastasis


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF PHARMACY

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: Fort Lauderdale-Davie

ORG_NAME: NOVA SOUTHEASTERN UNIVERSITY

ORG_STATE: FL

PHR: Project Narrative This T34 U-RISE@NSU program at NSU aims to provide an enhanced training experience to STEM undergraduate students from underrepresented populations, supporting them to enter and complete biomedical graduate programs. The program stands on two key pillars necessary for this kind of proposal: an excellent research infrastructure and an extensive minority population of Hispanics and other underrepresented minorities, with doctoral career aspirations. The program will achieve its objectives by development and implementation of 1) a foundational education program in the biomedical sciences, 2) a collaborative laboratory-based research experience, 3) a summer research experience, and 4) a career development program.

PI_NAMEs: GANNETT, PETER M. (contact)

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TERMS: Bachelor's Degree;Biological Sciences;career;career development;college;Degree program;design;Doctor of Philosophy;Education;Educational process of instructing;Educational workshop;Enrollment;experience;faculty mentor;Funding;Goals;Graduation Rates;Grant;hands on research;Hispanic;laboratory experience;matriculation;Mentors;Mission;Nature;Population;programs;Records;recruit;Reproducibility;Research;Research Activity;research facility;Research Institute;Research Personnel;Research Training;Science;skills;Source;stem;Students;summer internship;Thinking;Training;undergraduate student;Underrepresented Minority;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: U-RISE at Nova Southeastern University

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - D[TWD-D]


ADMINISTERING_IC: AI

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Genetics;Infectious Diseases

ORG_CITY: ATLANTA

ORG_DEPT: PEDIATRICS

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: NARRATIVE The bacterial pathogen Pseudomonas aeruginosa causes life-threatening infections in immunocompromised and hospitalized individuals, and a better understanding of how it causes infections will be instrumental for the development of new treatments. This research aims to understand how P. aeruginosa senses its environment during an infection in order to produce a toxic molecule that degrades human tissue and subverts the immune system in lung, wound, and eye infections. Findings from this research could support the development of new treatments for P. aeruginosa infections.

PI_NAMEs: ROBINSON, RACHEL EVANS (contact)

PROGRAM_OFFICER_NAME: ERNST, NANCY L

PROJECT_TERMS: Acute;Affect;Animal Model;Antibiotic Resistance;Bacteria;Binding;Biochemical;Body Temperature;Caring;Chronic;cost;Cystic Fibrosis;Development;Disease;Environment;Environmental Risk Factor;Enzymes;Equilibrium;experience;Eye Infections;Fluorescence;Gene Expression;Genetic;Genetic Diseases;Genetic Transcription;Goals;Green Fluorescent Proteins;Growth;Hospitalization;Human;Human body;human tissue;Immune system;Immunocompromised Host;Immunoprecipitation;improved;Individual;Infection;Innate Immune System;insight;Iron;Knowledge;Laboratory Finding;Larva;Lead;Life;Lung infections;Measures;mortality;Moths;Nosocomial Infections;novel;novel therapeutic intervention;opportunistic pathogen;pathogen;Pathogenesis;pathogenic bacteria;Patients;Persons;Physiologic Thermoregulation;Principal Investigator;Production;promoter;Protein Secretion;Pseudomonas aeruginosa;Pseudomonas aeruginosa infection;Pseudomonas serine proteinase;Regulation;Reporter;Research;response;Role;Sepsis;Serine Protease;Sigma Factor;Stimulus;Temperature;Testing;Therapeutic;Tissues;Training;transcription factor;Up-Regulation;ventilator-associated pneumonia;Virulence;Virulence Factors;Wound Infection

PROJECT_TITLE: Regulation of the Pseudomonas aeruginosa protease PrpL by temperature and iron


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cocaine;Drug Abuse (NIDA only);Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: WINSTON-SALEM

ORG_DEPT: NEUROSCIENCES

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

ORG_STATE: NC

PHR: Project Narrative Of the estimated 5.2 million Americans reporting cocaine use in the year of 2020, 1.3 million met the criteria for cocaine use disorder (CUD) – a disease for which there are no FDA-approved treatments. Cocaine-induced disruptions of circadian (24-hour) and diurnal (night/day) rhythms are significant risk factors for the development of CUD and relapse. The proposed studies will examine the influence of chronic cocaine intake patterns on diurnal rhythms of acetylcholine and DA release to provide new mechanistic targets and pose times throughout the day that may be most effective in treating CUD.

PI_NAMEs: IACINO, MELODY COURTNEY-LYNN (contact)

PROGRAM_OFFICER_NAME: FALCON-MORALES, EDGARDO

PROJECT_TERMS: Acetylcholine;Affect;American;Animals;Architecture;Behavior;Biological Rhythm;Cells;cholinergic;Cholinergic Receptors;Chronic;Circadian Dysregulation;Cocaine;Cocaine Abuse;cocaine exposure;cocaine seeking;cocaine self-administration;cocaine use;Cocaine use disorder;Consumption;Corpus striatum structure;Cues;Darkness;Data;Development;Disease;Diurnal Rhythm;Dopamine;Drug usage;Electrophysiology (science);Exhibits;FDA approved;Fiber;fluorescence imaging;Hour;insight;Intake;Interneurons;Intravenous;Light;Link;Long-Term Effects;Mediator;meetings;mesolimbic system;Modeling;motivated behavior;neural;neural circuit;neurochemistry;Neurons;Nicotinic Receptors;novel;Nucleus Accumbens;patch clamp;Pathway interactions;Pattern;Periodicity;Persons;Phase;Photometry;Rattus;Recording of previous events;Relapse;relapse risk;Reporting;Research;response;reuptake;Rewards;Risk Factors;Rodent;Role;Self Administration;Signal Transduction;Time;United States;Variant

PROJECT_TITLE: Diurnal Variation in Acetylcholine Modulation of Dopamine Dynamics Following Chronic Cocaine Intake


FUNDING_MECHANISM: OTHERS

ORG_CITY: ANN ARBOR

ORG_STATE: MI

PHR: Patients with rheumatoid arthritis frequently use glucocorticoids (GCs) despite their known toxicity and the risk of adverse symptoms when they are tapered. Clinicians cannot predict how a given patient will respond to GC dose reduction, as existing studies do not examine taper-related symptoms as predictors of taper success, or evaluate how patient factors may affect such symptoms. The proposed research will a) prospectively evaluate tolerance to GC dose reduction among RA patients; b) develop multi-dimensional phenotypes of GC taper response that can be used to design tailored GC tapering strategies.

PI_NAMEs: WALLACE, BETH ILENE (contact)

PROJECT_TERMS: Adrenal gland hypofunction;Adrenal Glands;Affect;American;arm;Asthma;Autoimmune;Autoimmune Diseases;Award;Biological;brain fog;care providers;career;career development;Central Nervous System;central sensitization;Cessation of life;Chronic Obstructive Pulmonary Disease;Classification;Clinical;clinical phenotype;Clinical Sciences;Clinical Trials;Clinical Trials Design;cohort;Data;design;Dimensions;Dose;Endocrine;Etiology;experience;Fatigue;Female;Fracture;functional improvement;Funding;Future;Glucocorticoids;Goals;Gout;Guidelines;high risk;Hyperalgesia;Immune;immune activation;immunomodulatory therapies;improved;Individual;Infection;Inflammatory Arthritis;innovation;joint injury;Linear Regressions;Link;Logistic Regressions;Measures;medical specialties;Mentors;Mentorship;Methodology;Methods;military veteran;Minor;Moods;multimodality;Myalgia;Myocardial Infarction;Neurologic;Opioid;opioid use disorder;Oral;patient response;patient tolerability;Patients;personalized approach;personalized medicine;Pharmaceutical Preparations;Phenotype;Physicians;Population;predicting response;predictive signature;Prednisone;primary outcome;programs;prospective;Prospective cohort;Protocols documentation;Publications;Publishing;Qualifying;randomized trial;randomized, clinical trials;Recommendation;Research;research and development;Research Personnel;Research Priority;response;Rheumatoid Arthritis;rheumatologist;Risk;Running;Scientist;Sequential Treatment;Statistical Models;Steroids;Stroke;success;symposium;Symptoms;Techniques;Testing;Toxic effect;Training;treatment optimization;Treatment outcome;Treatment Protocols;treatment response;treatment strategy;Uncertainty;United States;Veterans;Veterans Health Administration;Work;Writing

PROJECT_TITLE: Using SMART Design to Develop Dynamic Treatment Regimens for Glucocorticoid Tapering


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric

ORG_CITY: WEST LAFAYETTE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: Public Health Relevance (Project Narrative) This project is relevant to NIH’s mission by providing fundamental knowledge regarding cellular and circuit mechanisms underlying behavioral abnormalities associated with Scn2a deficiency. Knowledge gained through the completion of this project provides the basis for the developmental of novel therapeutic interventions to treat autism spectrum disorder related to Scn2a deficiency.

PI_NAMEs: YANG, YANG  (contact)

PROGRAM_OFFICER_NAME: DOSS, ARGENIA LANISHA NECOLE

PROJECT_TERMS: Address;Adult;Affect;Agonist;Animal Behavior;anxiety-like behavior;autism spectrum disorder;awake;Behavior;Behavioral;behavioral impairment;behavioral outcome;behavioral response;behavioral study;Brain;Characteristics;Child;clinically relevant;Data;density;Development;Disease;Disparate;efficacy evaluation;Electrodes;Electrophysiology (science);Elements;Equilibrium;excitatory neuron;Frequencies;gamma-Aminobutyric Acid;Genes;Genetic;Genetic study;Heterozygote;hippocampal pyramidal neuron;Human;Impairment;in vivo;innovation;insight;interest;Interneurons;Intervention;Knock-out;Knockout Mice;Knowledge;Length;loss of function mutation;Maps;Medial;Mission;Modeling;mouse model;Mus;Mutate;Mutation;Neurodevelopmental Disorder;Neurons;neuropathology;novel;novel therapeutic intervention;optogenetics;Outcome;patch clamp;Pathway interactions;Perinatal;pharmacologic;Pharmacology;postsynaptic;Predisposition;Prefrontal Cortex;Property;Protein Truncation;public health relevance;receptor;Research Personnel;Resolution;response;Rest;restoration;SCN2A protein;Signal Transduction;Slice;social;Social Behavior;social communication impairment;social deficits;Social Interaction;Sodium Channel;spatiotemporal;Synapses;synaptic function;Technology;Testing;therapeutic development;therapy development;TNFSF5 gene;transcriptome sequencing;United States;United States National Institutes of Health;voltage;Work

PROJECT_TITLE: Neuronal and Behavioral Deficits Associated with Scn2a Deficiency in Autism Spectrum Disorder

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Breast Cancer;Cancer;Women's Health Research

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: Project Narrative Invasive lobular carcinoma (ILC) is the second most common subtype of breast cancer and demonstrates unique features supporting its highly invasive and metastatic nature. Despite this, lack of effective models has left ILC largely understudied with no insight into the mechanics underlying its invasive potential. This proposal aims to dissect the tumor-extracellular matrix interactions of invading ILC cells, in search of novel therapeutic targets.

PI_NAMEs: OLSON, ADAM WALLACE (contact)

PROGRAM_OFFICER_NAME: ODEH, HANA M

PROJECT_TERMS: Accounting;Address;Affect;Alleles;arm;Behavior;Binding;Biological;cancer cell;Carcinoma;cell type;Cells;chemotherapy;Clustered Regularly Interspaced Short Palindromic Repeats;Collagen;Collagen Type I;Complex;Cre driver;Data;density;Deposition;Diffuse;ductal breast carcinoma;E-Cadherin;Early Diagnosis;Engraftment;experimental study;Extracellular Matrix;Fibroblasts;Gene Expression Profile;Genetic Transcription;Growth;Housing;Human;improved;in vivo;Individual;individualized medicine;inducible Cre;insight;Invaded;Invasive Lesion;Laboratories;Left;Lobular Carcinoma;LoxP-flanked allele;Malignant Breast Neoplasm;Malignant Epithelial Cell;Malignant Neoplasms;mammary epithelium;Matrix Metalloproteinases;Mechanics;mechanotransduction;Mediating;Membrane;Mesenchymal;migration;MMP14 gene;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;Mutation;Nature;Neoplasm Metastasis;Neoplasms;neoplastic cell;new therapeutic target;Normal Cell;novel;Patients;Pattern;Peptide Hydrolases;PIK3CG gene;Play;Process;programs;Radiation therapy;recruit;Research;Resistance;Role;Signal Transduction;single-cell RNA sequencing;Stromal Cells;System;therapeutic target;Tissues;transcriptomics;tumor;tumor progression;tumorigenic;Xenograft Model

PROJECT_TITLE: Extracellular Matrix Remodeling and the Control of Invasive Lobular Carcinoma Progression


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Parkinson's Disease

ORG_CITY: CINCINNATI

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF CINCINNATI

ORG_STATE: OH

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because alpha-synuclein pathology is linked to various neurological diseases including Parkinson’s disease and Lewy body dementia, and understanding the underlying disease mechanisms will allow us to develop a novel intervention therapy. Thus, this research is relevant to the NIH’s mission that pertains to supporting the ongoing basic research, foster research that has immediate medical relevance, and encourage translational research that links the discoveries from basic research into therapeutic interventions for treating neurological disorders such as Parkinson’s disease and Lewy body dementia.

PI_NAMEs: BURRE, JACQUELINE ;DIAO, JIAJIE  (contact)

PROGRAM_OFFICER_NAME: SARRAF, SHIREEN AKHAVAN

PROJECT_TERMS: Affect;alpha synuclein;Amino Acids;Animal Model;Basic Science;Behavioral;Binding;Biochemical;Biological;Biological Assay;Biophysics;Cell Line;Cells;Collaborations;Communication;Complex;Data;Dementia;detection assay;Development;Disease;early onset;experimental study;Fluorescence Resonance Energy Transfer;Fostering;Functional disorder;functional improvement;FYN gene;Goals;Heterozygote;In Vitro;in vivo;innovation;insight;interdisciplinary approach;Kinetics;Knockout Mice;Label;Lewy Bodies;Lewy Body Dementia;Life;Link;Mediating;Medical;Membrane;Membrane Fusion;Methods;Missense Mutation;Mission;Molecular;Molecular Chaperones;Molecular Conformation;monomer;Mus;mutant;Mutation;nanopore;Nervous System Disorder;Neurons;NMR Spectroscopy;novel;Outcome;Parkinson Disease;particle;Pathologic;Pathology;Phospholipids;Physiological;preservation;Presynaptic Terminals;prevent;Property;Proteins;Public Health;Recombinants;Research;Role;single molecule;SNAP receptor;solid state;Synapses;Synaptic Transmission;Synaptic Vesicles;synuclein;synucleinopathy;Techniques;Testing;Therapeutic Intervention;Toxic effect;Translational Research;United States National Institutes of Health;VAMP-2;Variant;Vesicle;vesicle-associated membrane protein

PROJECT_TITLE: The role of VAMP2 in alpha-synuclein function and pathology

STUDY_SECTION: BBM

STUDY_SECTION_NAME: Biochemistry and Biophysics of Membranes Study Section[BBM]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: Aurora

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative The proposed studies will elucidate action potential firing mechanisms in different types of afferent neurons in the peripheral vestibular system using a combination of electrophysiological, immunohistochemical and mathematical modeling approaches. Understanding how vestibular information is relayed to the brain has important implications for developing new therapies involving pharmacological approaches and design of implants for patients with vestibular dysfunction.

PI_NAMEs: RENNIE, KATHERINE JANET (contact)

PROGRAM_OFFICER_NAME: CYR, JANET

PROJECT_TERMS: 3-Dimensional;Action Potentials;Adult;afferent nerve;Afferent Neurons;analog;Artificial Implants;Axon;Biophysics;Brain;Cell Separation;cell type;Cells;Characteristics;Code;combat;Crista ampullaris;Custom;cyclic-nucleotide gated ion channels;Data;Dendrites;density;Development;Dissociation;effective therapy;Electric Stimulation;electrical property;Electrophysiology (science);Epithelium;equilibration disorder;Equilibrium;Exhibits;extracellular;Face;Fiber;Frequencies;Functional disorder;Future;Generations;Geometry;Gerbils;Goals;Hair;Hair Cells;Implant;implant design;Individual;insight;Ion Channel;Kinetics;Label;Laboratories;mathematical model;Mediating;Membrane Potentials;Modeling;Motion;Nature;Nerve Fibers;neural;novel;novel therapeutics;Organ;otoconia;patch clamp;Patients;Pattern;Peripheral;pharmacologic;Pharmacologic Substance;Pharmacotherapy;Phase;Physiologic pulse;Physiological;Population;postnatal;postsynaptic;Potassium Channel;Preparation;Process;Property;Prosthesis;Protocols documentation;receptor;regional difference;Regulation;response;Rodent;Role;SCN8A gene;segregation;Sensory;Shapes;Signal Transduction;Slice;Stimulus;Synapses;Testing;Tetrodotoxin;therapeutic target;Tissues;tool;Type I Hair Cell;Type II Hair Cell;Utricle structure;Variant;Vestibular dysfunction;Vestibular epithelia;Vestibular function;Vestibular Hair Cells;vestibular prosthesis;vestibular system;voltage;voltage clamp;Work;Writing

PROJECT_TITLE: Ion Channels and Excitability in the Peripheral Vestibular System

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_CITY: LITTLE ROCK

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIV OF ARKANSAS FOR MED SCIS

ORG_STATE: AR

PHR: Project Narrative The most common forms of congenital birth defects (e.g., Down’s syndrome) and about 35% of miscarriages are caused by defects in chromosome segregation during meiosis in one of the parents. Dr. Wahls and his colleagues are using fission yeast as a model organism to determine what regulates the positioning of meiotic recombination, which is essential for proper chromosome segregation. This work will help us to understand the causes of Down’s syndrome and miscarriage and will identify targets of potential diagnostic value.

PI_NAMEs: WAHLS, WAYNE P (contact)

PROGRAM_OFFICER_NAME: MACARTHUR, LINDA

PROJECT_TERMS: Affinity;Alleles;Aneuploidy;Base Pairing;Binding;Binding Proteins;Biological;Biological Assay;Biological Models;candidate identification;Catalysis;chromatin remodeling;Chromosome Mapping;Chromosome Segregation;Code;Complex;Congenital Abnormality;Coupled;Couples;Defect;diagnostic value;DNA;DNA biosynthesis;DNA Sequence;DNA sequencing;Down's Syndrome;ds-DNA;Elements;Etiology;experimental study;Fission Yeast;forward genetics;Frequencies;fungus;Genetic Recombination;Genetic Transcription;Genetic Variation;Genome;Goals;Haploidy;Histones;Homologous Gene;improved;in vivo;innovation;Insecta;insight;Length;Mass Spectrum Analysis;Measures;Meiosis;Meiotic Recombination;model organism;Molecular;Natural Selections;next generation;Nucleosomes;Nucleotides;Organism;Parents;Pathway interactions;Population;Positioning Attribute;precise genome editing;Process;Proteins;Randomized;Regulation;Regulatory Element;Research;Resolution;Sampling;segregation;Sequence-Specific DNA Binding Protein;Site;Specificity;SPO11 gene;Spontaneous abortion;Technology;Testing;tool;Vertebrates;Work;yeast genome;Yeast Model System

PROJECT_TITLE: Systematic elucidation of DNA sequence codes that regulate meiotic recombination

STUDY_SECTION: MGA

STUDY_SECTION_NAME: Molecular Genetics A Study Section[MGA]


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Aging;Climate-Related Exposures and Conditions;Clinical Research;Diabetes;Endocrine Disruptors;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Prevention;Social Determinants of Health;Women's Health Research

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because given the widespread exposure to metabolism disrupting chemicals and the burden of T2D and MetS in the United States and globally, the public health impact would be substantial if these modifiable exposures are reduced. The findings of this project will highlight the clinical and public health utility of exposome for risk assessment, prevention, and precision health which will effectively reduce metabolic disease risk.

PI_NAMEs: PARK, SUNG KYUN  (contact)

PROGRAM_OFFICER_NAME: CUI, YUXIA

PROJECT_TERMS: Address;Age Years;Air Pollutants;Air Pollution;Area;Biological;Biological Markers;Blood;Blood Glucose;Blood specimen;Body mass index;Chemicals;Clinical;cohort;Communities;cost;demographics;Diagnosis;Diagnostic;diagnostic signature;Diet;Discrimination;Disease;Disease Progression;disorder risk;Early Diagnosis;Early Intervention;effective intervention;environmental chemical;Environmental Exposure;Environmental Health;Environmental Risk Factor;epidemiology study;Ethnic Origin;Evaluation;Evolution;Exposure to;Family;Fasting;fine particles;Future;Genotype;Goals;health data;Human;improved;Individual;inorganic phosphate;insight;late life;Life Style;Link;Longitudinal cohort;machine learning method;Mass Spectrum Analysis;Measures;Metabolic;Metabolic Diseases;metabolic phenotype;Metabolic syndrome;Metabolism;metabolome;metabolomics;Metals;middle age;Midlife women;multi-ethnic;multi-racial;Natural History;Newly Diagnosed;Nitrogen Dioxide;Non-Insulin-Dependent Diabetes Mellitus;novel;Organophosphates;Outcome;Ozone;Parabens;Particulate Matter;Pathogenesis;Perimenopause;Pesticides;Phenols;phthalates;Play;Poly-fluoroalkyl substances;Population;Precision Health;Predisposition;Prevalence;Prevention;Process;Prospective Studies;Public Health;Recording of previous events;Research;Resolution;response;Risk;Risk Assessment;Risk Factors;Risk Marker;risk prediction;risk prediction model;risk stratification;Role;Sampling;Serum;Study of Women's Health Across the Nation;Testing;Toxic effect;United States;Vulnerable Populations;Woman;Women's study

PROJECT_TITLE: Integrated exposome profiling to identify environmental risk factors of metabolic disease in mid- and late-life

STUDY_SECTION: KEDD

STUDY_SECTION_NAME: Kidney Endocrine and Digestive Disorders Study Section[KEDD]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Digestive Diseases;Inflammatory Bowel Disease;Prevention

ORG_CITY: BOSTON

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

ORG_STATE: MA

PHR: Project Narrative  We have recently discovered a new class of highly potent and drug-like aryl hydrocarbon receptor (AHR) immune modulator derived from an indole-pyridine scaffold, which are suitable for oral administration and display promising pharmacokinetic and pharmacodynamic profiles. We have confirmed that these compounds potently increase IL-22 production, accelerate gut mucosal healing, and restore intestinal integrity in a murine model of colitis, as well as induce IL-22 expression in human T cells from healthy adults and adults with active inflammatory bowel disease (IBD). Significantly, we have identified stringent structural requirements for ligand- induced activation of AHR that provides a framework for the rational design of intestine-selective agonists, which we believe will represent an important advance for the treatment of IBD.

PI_NAMEs: CHAIKOF, ELLIOT  (contact);SUN, LIJUN

PROGRAM_OFFICER_NAME: SHEA-DONOHUE, TEREZ

PROJECT_TERMS: Acceleration;Adaptor Signaling Protein;Adult;Agonist;Antibodies;Aryl Hydrocarbon Receptor;aryl hydrocarbon receptor ligand;Bacterial Translocation;Biodistribution;Cells;Chemicals;Coculture Techniques;Colitis;computer studies;cost;design;dietary;disorder risk;Dose;drug candidate;Drug Design;dysbiosis;Effectiveness;Ensure;Enteritis;epithelial repair;Epithelium;Exhibits;experimental study;Functional disorder;gastrointestinal epithelium;Generations;Genetic Polymorphism;genome wide association study;genotoxicity;Gut Mucosa;healing;Human;Immune;Immune system;Immunity;Immunologic Receptors;Immunomodulators;in vivo;Indoles;Infection;infection risk;Inflammatory Bowel Diseases;Inflammatory Response;Innate Immune System;interleukin-22;Intervention;intestinal epithelium;Intestines;Invaded;Investigation;Lead;lead optimization;Ligands;Maintenance;Malignant Neoplasms;Mediating;microbial;microbial homeostasis;microorganism;Modeling;mouse model;Mucosal Immune Responses;Mucosal Immune System;Mucous Membrane;murine colitis;Mus;Oral Administration;Organoids;Parents;Pathogenicity;Pathway interactions;Patients;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;Phase;plant metabolites;Predisposition;Prevention;Process;Production;Protocols documentation;pyridine;rational design;repaired;Reporting;restoration;Risk;Safety;scaffold;Science;Signal Transduction;Structure;Susceptibility Gene;T-Lymphocyte;Therapeutic;Tissues;Toxic effect;Treatment Efficacy

PROJECT_TITLE: Structure-Guided Design of Intestine-Selective AHR Agonists for Restoration of Gut Barrier Integrity in IBD

STUDY_SECTION: SBCB

STUDY_SECTION_NAME: Synthetic and Biological Chemistry B Study Section[SBCB]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Neurosciences

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

PHR: NARRATIVE There remains a major unmet need for developing novel imaging platforms to visualize network-scale activity dynamics during complex, unrestrained behaviors. We propose to develop a novel head-mounted computational miniature mesoscope that applies computational imaging principle to enable recording cortex-wide Ca2+ dynamics with single-cell resolution of neural activities in freely behaving mice. We will apply this new technology to visualize the cross-area, network-scale activity dynamics that guide social interactions between familiar partners - one of the most integrative, multi-sensory, and cognitively demanding forms of neural processing.

PI_NAMEs: TIAN, LEI  (contact)

PROGRAM_OFFICER_NAME: KUMSA, DOE WONDWOSSEN

PROJECT_TERMS: Address;Algorithms;Animals;Area;Behavior;Behavioral;Benchmarking;Biological;Brain;Brain region;brain tissue;Cells;Cognition;Cognitive;Complex;Data;deep learning;design;experimental study;Fluorescence Microscopy;Goals;Head;Histologic;Image;imaging capabilities;imaging platform;improved;in vivo;in vivo imaging;Individual;innovation;Joints;lens;Lighting;long term memory;Measurement;Measures;meetings;Mental disorders;Miniaturization;Motivation;Motor;multidisciplinary;multisensory;Mus;neural;neural circuit;Neurodegenerative Disorders;Neurons;Neurophysiology - biologic function;Neurosciences;neurotransmission;new technology;novel;olfactory bulb;Optics;Perception;Performance;preservation;prototype;Public Health;real-time images;Recovery;Resolution;Sensory;social;Social Behavior;Social Interaction;Structure;System;Techniques;Technology;Testing;Three-Dimensional Imaging;Tissues;Training;Visualization;wearable device;Weight;Work

PROJECT_TITLE: Computational Miniature Mesoscope for Cortex-wide, Cellular resolution Ca2+ Imaging in Freely Behaving Mice


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF OSTEOPATHIC MEDICINE

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Breastfeeding, Lactation and Breast Milk;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Lung;Nutrition;Pediatric;Physical Rehabilitation;Rehabilitation

ORG_CITY: ATHENS

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: OHIO UNIVERSITY ATHENS

PHR: Project Narrative Otherwise healthy children who have been introduced to complementary foods outside of a critical developmental window can develop structural abnormalities of the orofacial region and aberrant chewing behaviors. While a sustained liquid diet can safely provide nutrition to these children, how to best remediate and safely facilitate maturation of their chewing patterns is not known. This project will test two treatment strategies on the recovery of oral function in an animal model to guide clinical decisions about feeding rehabilitation in healthy children and lay the groundwork for clinical decision-making for healthy preterm infants and children with underlying physical and/or neurological disabilities that delay the acquisition of oral skills.

PI_NAMEs: WILLIAMS, SUSAN H (contact)

PROGRAM_OFFICER_NAME: CHAKHTOURA, NAHIDA ABDO

PROJECT_TERMS: Adolescent;Affect;Age;Age Months;Age Years;Animal Model;Animals;Behavior;Behavioral;Biological Assay;Biomechanics;Bottle feeding;Breastfed infant;Child;Clinical;clinical decision-making;clinical practice;Complex;Control Animal;Coupling;critical period;Data;Deglutition;Development;Diet;dietary;early childhood;Electromyography;Exhalation;Exposure to;Family suidae;feeding;Feeding behaviors;Fluoroscopy;Food;Foundations;Frequencies;Functional disorder;Funding;Future;Growth;Growth and Development function;Health;Human;Human Subject Research;Impairment;improved;Infant;Ingestion;Inhalation;Jaw;juvenile animal;kinematics;Length;Liquid substance;Longitudinal Studies;Mastication;Modeling;Motor;motor control;Movement;Muscle;Neurological disability;neuromuscular;nutrition;Nutritional;Nutritional Support;Oral;Oral Stage;orofacial;Oropharyngeal;Outcome;Pattern;Performance;Pharyngeal structure;Phase;physically handicapped;Physiological;Physiology;Population;Premature Infant;Probability;Process;Property;rapid growth;Recovery;rehabilitation strategy;Rehabilitation therapy;remediation;Research;Respiration;respiratory;Risk;School-Age Population;Sensory;sensory input;sensory integration;skills;Solid;Speed;Structural defect;Structure;suckling;System;Testing;Texture;Tongue;Tooth structure;treatment comparison;treatment strategy;Variant;Weaning;Work

PROJECT_TITLE: A Comparison of Treatment Strategies for Recovery of Swallow and Swallow-Respiratory Coupling Following a Prolonged Liquid Diet in a Young Animal Model

STUDY_SECTION: MFSR

STUDY_SECTION_NAME: Motor Function, Speech and Rehabilitation Study Section[MFSR]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Conditions Affecting the Embryonic and Fetal Periods;Depression;Fetal Alcohol Spectrum Disorders (FASD);Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Mental Illness;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention;Substance Misuse

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: NARRATIVE: The proposed research study will investigate the relationship between the timing of prenatal alcohol exposure (PAE), DNA methylation at birth, and longitudinally-measured depressive symptoms across development in youth from two large population-based cohorts (the Avon Longitudinal Study of Parents and Children; ALSPAC; and Generation R; GenR), consistent with a discovery and replication approach. This research will identify the specific trimesters in pregnancy when prenatal exposure to alcohol may have greater influences on child DNA methylation and subsequent depressive symptoms in childhood and adolescence, as well as the role of DNA methylation in linking PAE to increased risk for depression. These findings will highlight key sensitive periods and potential therapeutic targets that might explain the multiple adverse outcomes linked to PAE and that can be harnessed in interventions and treatments aimed at reducing mental illness in people with fetal alcohol spectrum disorder.

PI_NAMEs: DUNN, ERIN CATHLEEN;LUSSIER, ALEXANDRE A (contact)

PROGRAM_OFFICER_NAME: POWELL, ELIZABETH

PROJECT_TERMS: Address;Adolescence;Adolescent;adverse outcome;Affect;Age;Age Years;alcohol exposure;alcohol measurement;Animals;Applications Grants;Behavioral;Biological;Biological Factors;Birth;Brain;Child;Childhood;Cognitive;Cognitive deficits;cohort;Conceptions;Cross-Sectional Studies;Data;depressive symptoms;Development;disorder risk;DNA Methylation;drinking;early life exposure;Environmental Risk Factor;Epigenetic Process;epigenome;experience;falls;Fetal Alcohol Exposure;Fetal Alcohol Spectrum Disorder;Future;General Population;Generations;Genetic;genetic risk factor;genome-wide;Growth;Health;Heterogeneity;high risk;Human;human data;improved;Individual;Intervention;Knowledge;Life Cycle Stages;life span;Link;Long-Term Effects;Longitudinal Studies;Measurable;Measures;Mediating;Mediation;Mendelian randomization;Mental Depression;Mental disorders;Mental Health;Methods;methylation pattern;Modeling;Modification;novel;offspring;Outcome;parental influence;Parents;Pathway interactions;Pattern;Personal Satisfaction;Persons;phenotypic data;Population;population based;Predisposition;Pregnancy;prenatal exposure;Prevention;programs;prospective;Psyche structure;Reporting;Research;Research Project Grants;research study;Residual state;Risk;Role;Sampling;Shapes;Signal Transduction;Structure;Symptoms;Testing;Therapeutic;therapeutic target;Time;Youth

PROJECT_TITLE: Sensitive periods for prenatal alcohol exposure: a longitudinal study of DNA methylation and subsequent mental health

STUDY_SECTION: AA

STUDY_SECTION_NAME: Neuroscience and Behavior Study Section[AA-4]


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Heart Disease;Neurosciences;Nutrition;Pediatric;Physical Activity;Prevention;Sleep Research

ORG_CITY: IRVINE

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: NARRATIVE This study will evaluate the complex relationships and interactions between sleep and aerobic fitness as they impact cardiovascular disease risk factors early in life. We will include state-of-the-art assessments of sleep along with neurocognitive assessment to the pediatric arm of the NIH Common Fund Molecular Transducers of Physical Activity Consortium (MoTrPAC) study. Results will direct future clinical trials focused on improving sleep and aerobic fitness in developing youth to improve cardiovascular disease risk factor and ultimately improve prevention of disabling disease.

PI_NAMEs: BENCA, RUTH M;NEIKRUG, ARIEL BOAZ (contact)

PROGRAM_OFFICER_NAME: SHIROMA, ERIC JITSUO

PROJECT_TERMS: 17 year old;actigraphy;Acute;Adolescence;Adolescent;Adult;Aerobic Exercise;Ancillary Study;arm;Attention;Autonomic nervous system;biobehavior;biopsychosocial;Blood Pressure;blood pressure elevation;Body mass index;Cardiovascular Diseases;cardiovascular disorder risk;Cardiovascular system;Child;Childhood;circadian;Clinical Trials;Cognitive;cohort;Complex;COVID-19;critical period;Cross-Sectional Studies;Data;data repository;Data Set;density;design;Development;Diet and Nutrition;disabling disease;disorder risk;Electroencephalography;endurance exercise;Epidemic;Ethnic Origin;Ethnic Population;Evolution;executive function;Exercise;exercise intervention;exercise regimen;exercise training;falls;fitness;Funding;Future;Genomics;Goals;Growth and Development function;Guidelines;Health;Health Benefit;Heart Rate;heart rate variability;Homeostasis;Hormonal;Human;improved;improvement on sleep;Inflammation;Intervention;Knowledge;Laboratories;Life;life span;Link;Lipids;Maps;Measures;Medical;Memory;Mental Health;Metabolic;Metabolic syndrome;metabolomics;Molecular;Neurobiology;Neurocognitive;Non obese;novel;Obesity;Participant;Pathway interactions;Pattern;Phase;Phenotype;Physical activity;physical conditioning;Physical Fitness;physical inactivity;Physiological;Polysomnography;poor sleep;Population;Populations at Risk;Prevention;Process;prospective;Proteomics;Protocols documentation;psychologic;Puberty;Race;Randomized;recruit;response;Risk;Risk Factors;Role;Serum;sex;Sexual Development;Sleep;Sleep Deprivation;Surveys;Testing;therapy design;Transducers;United States National Institutes of Health;Youth

PROJECT_TITLE: Interacting mechanisms of sleep and aerobic fitness: Implications for health in the growing child

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


NIH_SPENDING_CATS: Cancer;Genetics;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: STONY BROOK

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

PHR: Project Narrative Rhabdomyosarcoma (RMS) is a pediatric cancer long overdue for potent treatments that target pathways specific to the disease. Myogenic differentiation factor 1 is a strong growth dependency specific to RMS, and this study aims to understand the molecular mechanisms underlying this relationship. Knowledge gained from this proposal will advance understanding of RMS pathophysiology and provide a foundation for investigation of novel therapeutics.

PI_NAMEs: CLEARY, CRISTIAN RYAN (contact)

PROGRAM_OFFICER_NAME: ADAMS, GREGORY

PROJECT_TERMS: anti-cancer research;BHLH Protein;Binding;Biological Assay;Cancer cell line;Caring;Cell Line;Cells;Cephalic;chemotherapy;Childhood;ChIP-seq;clinical care;clinical diagnosis;Complementary DNA;CRISPR interference;Dactinomycin;Data;Data Set;Dependence;Diagnosis;differential expression;Disadvantaged;Disease;Drug toxicity;Environment;experimental study;Failure;Family;fitness;Foundations;Functional disorder;functional genomics;Future;Genes;Genetic;Genetic Screening;genetic selection;Genetic Transcription;Goals;Growth;Helix-Turn-Helix Motifs;Incidence;insight;Investigation;Knock-out;Knowledge;Laboratories;Light;Malignant Childhood Neoplasm;Malignant Neoplasms;Mediating;Medical;member;Mentorship;Molecular;morphogens;Muscle;Muscle Fibers;myogenesis;Neoplasms;novel strategies;novel therapeutics;Pathway interactions;Patients;pediatric patients;Phenotype;Population;programs;Proliferating;Regulation;Research;Research Proposals;Resolution;Resources;Rhabdomyosarcoma;Role;science education;Scientist;Skeletal Myoblasts;skills;small molecule inhibitor;Solid Neoplasm;Sorting;Stains;standard of care;Survival Rate;Systemic Therapy;targeted treatment;Therapeutic;Toxic effect;Training Programs;transcription factor;transcriptome sequencing;tumor;tumor growth;United States;Universities;Vincristine

PROJECT_TITLE: The Dependency on MYOD for Growth in Rhabdomyosarcoma


ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: Local mechanisms within target cells modulate TH signaling. These mechanisms involve transmembrane transporters of TH, intracellular deiodinases, and TRs, and explain cellular customization of TH signaling. Here we will explore how T4 levels affect TH signaling in cells that can transform T4 to T3.

PI_NAMEs: BIANCO, ANTONIO C (contact);GEREBEN, BALÁZS

PROGRAM_OFFICER_NAME: SECHI, SALVATORE

PROJECT_TERMS: Affect;Area;Astrocytes;Axon;Binding;Brain;brain cell;Cell membrane;cell type;Cells;Circulation;Cognition;Cytoplasm;deiodination;Dense Core Vesicle;Development;Disease;Down-Regulation;Elements;Exhibits;Exposure to;Extracellular Fluid;Face;Family;Feedback;Gene Modified;Genes;Genetic Transcription;Growth;Health;hormonal signals;Hormones;Hypothalamic structure;Impaired cognition;Impairment;improved;In Vitro;Iodide Peroxidase;Life;Light;Maps;median eminence;Mediating;Membrane Transport Proteins;Mental Depression;Metabolic;Metabolic Pathway;Metabolism;Modification;multicatalytic endopeptidase complex;Mus;Neurons;Organ;Paracrine Communication;paraventricular nucleus;Pathway interactions;Patients;Pituitary Gland;Plasma;Play;prevent;Production;prohormone;Reaction;Regulation;Role;Serum;Signal Pathway;Signal Transduction;Structure;System;targeted treatment;Thalamic structure;thyroid disruption;Thyroid Gland;Thyroid Hormone Receptor;Thyroid Hormones;Thyronines;Thyroxine;Time;Tissues;Triiodothyronine;type 2 deiodinase (D2);Ubiquitination

PROJECT_TITLE: Selenodeidinase Processing by the Proteasome System

STUDY_SECTION: MCE

STUDY_SECTION_NAME: Molecular and Cellular Endocrinology Study Section[MCE]


ADMINISTERING_IC: TR

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Clinical Research;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Rural Health

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: The Institute of Translational Health Sciences (ITHS) seeks to improve the quality and efficiency of clinical and translational research across Washington, Wyoming, Alaska, Montana, and Idaho and beyond. The Institute will achieve this goal through education and training, team building, community engagement, continuous process improvement, and advanced informatics.

PI_NAMEs: AMORY, JOHN K. (contact)

PROGRAM_OFFICER_NAME: RADMAN, THOMAS C

PROJECT_TERMS: Alaska;Benchmarking;Big Data;Career Choice;Career Mobility;Child;Clinic;Clinical;Clinical and Translational Science Awards;Clinical Data;Clinical Research;Clinical Sciences;clinical training;Clinical Trials;cohort;Collaborations;collaboratory;Communities;community academic partnership;community engagement;Community Health;Competence;data exploration;Data Science;data sharing;Disparity;diversity and equity;doctoral student;early-career faculty;Education;Educational Curriculum;Electronic Health Record;Ensure;Environment;Equity;evidence based guidelines;Faculty;Fostering;Fred Hutchinson Cancer Research Center;Funding;Future;Goals;Growth;Guidelines;Health;health training;Healthcare;Idaho;improved;Individual;Informatics;informatics tool;Infrastructure;innovation;Institution;Investments;Laboratories;Leadership;Learning;life span;Location;Machine Learning;Methods;Minority Groups;Montana;novel;outreach;Pathway interactions;Patients;Performance;Persons;Phase;Policies;pre-doctoral;Predictive Analytics;Process;process improvement;professional students;programs;Publications;Relationship-Building;remote technology;Research;Research Personnel;Research Project Grants;research to practice;Resources;Rewards;Role;Rural Community;Rural Health;Rural Population;Science;Services;skills;Special Population;success;System;Testing;Time;TNFSF15 gene;tool;Training;Training and Education;translational health science;Translational Research;translational scientist;Universities;Vision;Washington;Workforce Development;Wyoming


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Depression;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Mental Illness;Patient Safety;Physical Injury - Accidents and Adverse Effects;Prevention;Rehabilitation;Social Determinants of Health

ORG_CITY: AUSTIN

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

ORG_STATE: TX

PHR: Project Narrative / Public Health Significance This study aims to find an effective and sustainable approach to reducing disparities in accessing depression treatment and fall prevention services for an underserved and growing population group of low-income, racially diverse, homebound older adults. It will compare integrated approach to treat depression and prevent falls utilizing bachelor’s-level lay providers collocated in aging service agencies. The findings are expected to provide research evidence to guide implementation of a care delivery model that is scalable in the real world.

PI_NAMEs: CHOI, NAMKEE G (contact)

PROGRAM_OFFICER_NAME: PADGETT, LYNNE SLAUGHTER

PROJECT_TERMS: Acceleration;access disparities;Address;Admission activity;Adoption;Aging;aging population;arm;attentional control;Behavioral;budget impact;care coordination;care systems;Case Management;Chronic Disease;chronic pain;Clinic;Clinical;Clinical effectiveness;Clinical Trials;Communities;community living;Consent;cost;cost effective;cost effectiveness;Cost Effectiveness Analysis;COVID-19 sequelae;Data;delivered meals;depressive symptoms;disability;Disability Evaluation;Disparity;disparity reduction;Education;Effectiveness;Emergency department visit;EuroQOL;evidence base;Exercise;fall injury;Fall prevention;falls;fear of falling;follow-up;frailty;Frequencies;geriatric mental health;Hamilton Rating Scale for Depression;Health;Health Care Costs;health care service;health service use;Healthcare;Home;Hospitals;human old age (65+);Hybrids;Improve Access;improved;Income;incremental cost;Infrastructure;Institutionalization;Intervention;intervention delivery;Lead;Left;Licensing;Link;Low income;Low Income Population;Managed Care;Measures;Mediation;Medicare;Medicare/Medicaid;Mental Depression;Mental Health;Modeling;mortality;Nursing Homes;older adult;Outcome;Participant;peer;Pharmacotherapy;Physical therapy;Pilot Projects;Polypharmacy;Population;Population Group;Pragmatic clinical trial;pragmatic trial;premature;Prevention program;prevention service;primary outcome;problem solving therapy;Professional counselor;programs;Provider;psychosocial;Psychotherapy;Public Health;Quality of life;Quality-Adjusted Life Years;racial diversity;Randomized;Research;Risk;Risk Factors;Role;satisfaction;Schedule;secondary outcome;Self Care;Service delivery model;Services;skills;social;social engagement;Social isolation;Social Work;socioeconomic disadvantage;Source;success;Suicide;symposium;System;Telephone;Texas;Training;Transportation;Underserved Population;United States Centers for Medicare and Medicaid Services;uptake;World Health Organization Disability Assessment Schedule

PROJECT_TITLE: Integrated Tele-Behavioral Activation and Fall Prevention for Low-income Homebound Older Adults with Depression

STUDY_SECTION: CMPC

STUDY_SECTION_NAME: Clinical Management of Patients in Community-based Settings Study Section[CMPC]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Congenital Structural Anomalies;Genetics;Osteoporosis;Pediatric;Women's Health Research

ORG_CITY: PHILADELPHIA

ORG_DEPT: ORTHOPEDICS

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative  Osteoporosis and low bone mass are major public health problems, often accompanied by diminished bone formation, increased bone resorption, and impaired marrow vasculature. This proposal will investigate the multifaceted roles of a newly identified bone marrow adipose cell (MALP) in regulating bone development, homeostasis, aging, and injury repair. Discoveries from this study will be important for understanding the disease mechanism of osteoporosis and other bone disorders and identifying new therapies.

PI_NAMEs: QIN, LING  (contact)

PROGRAM_OFFICER_NAME: WILLIAMS, JOHN

PROJECT_TERMS: 3-Dimensional;Ablation;Address;Adipocytes;adiponectin;Adipose tissue;Adult;Age;Aging;Albers-Schonberg disease;Angiogenic Factor;Animal Model;Bacterial Infections;Biology;Blood capillaries;Blood Vessels;bone;Bone Development;Bone Diseases;bone loss;Bone Marrow;Bone Marrow Cells;bone mass;bone repair;Bone Resorption;Bone Resorption Inhibition;Bone Surface;Cell Lineage;Cell Physiology;cell type;Cells;Chondrocytes;Chronic Disease;Clinical;conditional knockout;Coupled;Coupling;CSF1 gene;Data;Development;diabetic bone disease;Disease;Environment;Fluorescent in Situ Hybridization;Fracture;Future;Gene Modified;Genetic study;Health Care Costs;Homeostasis;human old age (65+);Impairment;improved;in vivo;Injections;injury and repair;innovation;Intervention;Knockout Mice;Knowledge;Label;Lead;Lipids;long bone;LoxP-flanked allele;Malignant Neoplasms;Marrow;Mesenchymal;Mesenchymal Stem Cells;Modeling;Morbidity - disease rate;Morphology;Mus;Names;Nature;Normal tissue morphology;novel;novel therapeutics;Obesity;Osteoblasts;Osteoclasts;Osteocytes;Osteogenesis;osteogenic;Osteolysis;Osteoporosis;Ovariectomy;Pathologic;Pericytes;Phenotype;Physiologic pulse;Physiology;Play;Population;Postmenopausal Osteoporosis;postnatal development;Process;Proliferating;Property;Public Health;Radiation;Reporter;Research;response;response to injury;RNA;Role;Route;single nucleus RNA-sequencing;Skeletal Development;skeletal disorder;Source;spatiotemporal;spine bone structure;Stromal Cell-Derived Factor 1;Stromal Cells;Structure;Three-Dimensional Imaging;Tissues;TNFSF11 gene;transcriptome;transcriptomics;translational impact;VEGFA gene

PROJECT_TITLE: Control of bone physiology by a novel type of adipose cells


ORG_CITY: HOUSTON

ORG_NAME: MICHAEL E DEBAKEY VA MEDICAL CENTER

PHR: Almost 15% of Americans have chronic kidney disease (CKD), with an even higher rate in Veterans due to common risk factors such as high blood pressure and diabetes. People with CKD have a high risk of cardiovascular (CV) diseases, such as heart attacks, heart failure, and strokes. Extra fluid in the body, called volume overload, may lead to CV disease in people with CKD. It is unknown if volume overload develops in the earliest stages of CKD, when treating it with common, inexpensive medicines called diuretics may improve long-term CV outcomes. The first study will lay important groundwork to answer this question in Veterans with early CKD by comparing two ways to measure volume overload and studying the change in common symptoms like fatigue and short-term CV function after treatment with diuretic medicines. The second study will look at past medical records to determine if lowering blood pressure with diuretic medicines was associated with less CV disease in Veterans with CKD, which could affect choices of blood pressure medicine in patients with CKD.

PI_NAMEs: GREGG, LUCILE PARKER (contact)

PROJECT_TERMS: Active Learning;Address;Adult;Affect;Aftercare;American;Angiotensin Receptor;Angiotensin-Converting Enzyme Inhibitors;Animal Disease Models;Animals;Anti-Hypertensive Agents;Aspirin;Blood Pressure;blood pressure elevation;blood pressure medication;Body Weight;Brain natriuretic peptide;burden of illness;Cardiac;Cardiac Output;Cardiovascular Diseases;cardiovascular disorder risk;Cardiovascular Physiology;cardiovascular risk factor;Cardiovascular system;career;career development;Chest;Chronic Kidney Failure;Clinical;Clinical Trials;common symptom;coronary fibrosis;Data;Data Set;data warehouse;Databases;Dedications;design;Diabetes Mellitus;Dialysis procedure;Disease;Disease Outcome;Disease Progression;Diuretics;Dose;Echocardiography;Effectiveness;End stage renal failure;Ensure;Environmental Wind;Equipment;Event;extracellular;Fatigue;Functional disorder;Goals;Heart failure;hemodynamics;high risk;Human;Hypertension;improved;indexing;Individual;Informatics;Information Systems;Infrastructure;innovation;Intervention;Kidney;kidney fibrosis;Knowledge;Left Ventricular Mass;Link;Liquid substance;Measurement;Measures;Medical center;Medical Records;Medicare/Medicaid;Medicine;Mental Depression;Mentors;Mentorship;Modeling;Monitor;Myocardial Infarction;Natriuretic Peptides;novel;Outcome;Outpatients;Painless;Participant;patient oriented;Patient-Focused Outcomes;Patients;Peripheral Resistance;Persons;Pharmaceutical Preparations;Physical Examination;Physiology;Plasma;Population;population based;prevent;preventive intervention;pro-brain natriuretic peptide (1-76);Pulse Pressure;Quality of life;Questionnaires;Reporting;Research Design;Research Personnel;Retrospective cohort study;Risk;Risk Factors;Safety;Scientific Advances and Accomplishments;secondary analysis;Spectrum Analysis;standard of care;Stroke;symposium;Symptom Burden;Symptoms;targeted treatment;thiazide;tool;Training;translational model;Translational Research;United States;United States Department of Veterans Affairs;Veterans;Visit

PROJECT_TITLE: Association of diuretics with change in extracellular volume, natriuretic peptides, symptoms, and cardiovascular outcomes in CKD


NIH_SPENDING_CATS: Atherosclerosis;Biotechnology;Digestive Diseases;Gene Therapy;Genetics;Liver Disease

ORG_DEPT: PHYSIOLOGY

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: CRISPR/Cas9 based genome editing is a transformative technology that has the potential to cure some of the most severe human diseases. In this proposal we will develop new gene editing approaches to treat homozygous Familial Hypercholesterolemia. A major thrust of this work involves strategies for promoting the survival and growth of cells harboring therapeutic transgenes in the liver- which will be broadly applicable many monogenic diseases.

PI_NAMEs: LAGOR, WILLIAM RAYMOND (contact)

PROGRAM_OFFICER_NAME: LIU, LIJUAN

PROJECT_TERMS: Acids;adverse outcome;Alleles;Apolipoprotein E;Apolipoproteins B;Apoptosis;Atherosclerosis;autosome;Blood;Blood Component Removal;Catabolism;cell growth;Cells;Cessation of life;Cholesterol;Clustered Regularly Interspaced Short Palindromic Repeats;Codon Nucleotides;CRISPR/Cas technology;curative treatments;Data;Dialysis procedure;dietary manipulation;Disease;DNA;DNA cassette;Ensure;Essential Genes;ezetimibe;Failure;Familial Hypercholesterolemia;Family;fatty liver disease;gene correction;Gene Targeting;gene therapy;Gene therapy trial;gene-editing approach;gene-targeted therapy;Genes;Genetic;Genome;genome editing;Genomics;Goals;Grant;Hepatocyte;Human;human disease;hypercholesterolemia;Hyperlipidemia;Immune response;in vivo;inhibitor;Knockout Mice;LDLR gene;Length;Life;Lipoproteins;Liver;Liver diseases;liver transplantation;Location;loss of function mutation;Low Density Lipoprotein Receptor;Low-Density Lipoproteins;Macaca;Mendelian disorder;Morbidity - disease rate;mortality;mouse model;mRNA Stability;Mus;Mutation;novel;novel strategies;particle;Patients;Pharmaceutical Preparations;Physiology;Plasma;pre-clinical;preservation;Procedures;Process;promoter;Protein Region;Proteins;Quality of life;Rare Diseases;Receptor Gene;Regenerative capacity;repaired;Reproducibility;Site;standard of care;System;Technology;Testing;therapeutic genome editing;therapeutic protein;therapeutic transgene;Time;Transcriptional Regulation;Transgenes;tumorigenesis;Tyrosine;uptake;Viral;western diet;Work;Xanthomas

PROJECT_TITLE: Genetic Repair of Familial Hypercholesterolemia

STUDY_SECTION: NMHD

STUDY_SECTION_NAME: Nutrition and Metabolism in Health and Disease Study Section[NMHD]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric

ORG_CITY: SAINT LOUIS

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative The difﬁculties faced by individuals with autism to recognize the faces of others and read emotional and social cues from facial expressions can pose signiﬁcant challenges that negatively impact their quality of life by increasing anxiety and furthering social isolation. This study aims to use functional neuroimaging to investigate the underlying neural mechanisms of facial processing in individuals with autism to ascertain the precise contribution of the face processing regions to this core deﬁcit by combining the latest engineering modeling techniques and cognitive neuroscience. Our goal is to elucidate aberrant functional brain mechanisms that may underly facial processing differences and identify how this information may contribute to our understanding of the trajectory of autism, potentially add to autism screening criteria, and facilitate reﬁnement of interventions.

PI_NAMEs: WANG, SHUO  (contact)

PROGRAM_OFFICER_NAME: GILOTTY, LISA

PROJECT_TERMS: adolescent with autism spectrum disorder;Adult;adult with autism spectrum disorder;Age;Amygdaloid structure;Anterior;Anxiety;Appearance;Area;autism spectrum disorder;autistic children;Automobile Driving;Back;Behavioral;Biological;Brain;Brain region;Child;Code;cognitive neuroscience;Collaborations;comparison control;Complex;computer science;Cues;Data;deep neural network;Development;Disease;Emotional;Engineering;Eye;Eye Movements;Face;face perception;Face Processing;Facial Expression;Facial Expression Recognition;Functional Magnetic Resonance Imaging;fusiform face area;Gender;Goals;grasp;Human;improved;Individual;individuals with autism spectrum disorder;inferotemporal cortex;insight;Intervention;intervention refinement;Investigation;Judgment;Life;Literature;Modeling;Moods;neural;neural model;neuroimaging;Neurologic;neuromechanism;novel;Outcome;Participant;Perception;Persons;Population;predictive modeling;Prefrontal Cortex;Protocols documentation;Quality of life;Race;Research;response;screening;Shapes;showing emotion;skills;Skin;social;social deficits;social implication;Social Interaction;Social isolation;Spatial Distribution;Stimulus;Techniques;Testing;Texture;Time;Training;trait;trustworthiness;Variant;vector;visual stimulus;visual tracking;Visualization;Work

PROJECT_TITLE: Model-Based Investigation of Aberrant Neural Face Representation in Autism


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Clinical Research;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Mental Health;Mental Illness;Neurosciences;Psychosis

ORG_CITY: MONTREAL

ORG_COUNTRY: CANADA

ORG_FIPS: CA

ORG_NAME: SAINTE-JUSTINE UNIVERSITY HOSPITAL CTR

ORG_STATE: PQ

PHR: PROJECT NARRATIVE Neuropsychiatric manifestations are common in Rare Genetic Disorders (RGDs), affecting brain development and functioning throughout the lifespan; copy number variants (CNVs) at 22q11.2 and 16p11.2 loci are among the most common RGDs impacting developmental psychopathology. We propose to capitalize on highly informative samples and integrate prospective dimensional and categorical phenotyping with whole genome sequencing across these reciprocal CNVs. This work will identify convergent risk mechanisms for developmental neuropsychiatric disorders that have relevance to the broader population.

PI_NAMEs: JACQUEMONT, SEBASTIEN  (contact)

PROGRAM_OFFICER_NAME: MEINECKE, DOUGLAS L

PROJECT_TERMS: 16p11.2;22q11.2;adverse outcome;Affect;Algorithms;Anxiety;Anxiety Disorders;Architecture;Attention;Attention deficit hyperactivity disorder;Attentional deficit;autism spectrum disorder;Behavior;Brain;case control;Clinical;clinical diagnosis;clinical phenotype;clinical predictors;Cognition;Cognitive;cohort;Collaborations;Complement;Complex;Computing Methodologies;Copy Number Polymorphism;Data;Development;Developmental Course;Developmental Delay Disorders;Diagnosis;Dimensions;Disease;Early Intervention;Emotional;Emotions;Environment;Environmental Risk Factor;Evaluation;experience;externalizing behavior;Family;Family member;gene environment interaction;Genetic;genetic architecture;Genetic Determinism;genetic pedigree;Genetic Predisposition to Disease;Genetic study;genetic variant;genome resource;genome sequencing;genome wide association study;genomic locus;Genomics;Goals;Heterogeneity;Hyperactivity;Individual;Institution;Intellectual functioning disability;interest;International;Knowledge;large scale data;life span;Literature;Measures;Memory;Mental Depression;model building;Modeling;Molecular;National Institute of Mental Health;Nature;neurobehavioral;neurobiological mechanism;Neurocognition;neuropsychiatric disorder;neuropsychiatry;Online Systems;Outcome;Patients;personalized approach;phenomics;Phenotype;polygenic risk score;Population;Positioning Attribute;processing speed;prospective;Psychiatric Diagnosis;Psychopathology;Psychoses;Public Domains;rare genetic disorder;rare variant;recruit;Recurrence;Risk;risk prediction model;Sampling;Schizophrenia;social;Social Behavior;Specificity;symptomatology;Symptoms;Syndrome;theory of mind;tool;Variant;whole genome;Work

PROJECT_TITLE: 6/9: Dissecting the effects of genomic variants on neurobehavioral dimensions in CNVs enriched for neuropsychiatric disorders.


ORG_DEPT: OBSTETRICS & GYNECOLOGY

PHR: PROJECT NARRATIVE Aging in women is associated with diminished ovarian responses to follicle-stimulating hormone (FSH) as well as the oocyte quality. Our studies using novel genetic models expressing different age-specific FSH glycoforms will not only provide mechanistic insights but unequivocally test the role of FSH-mediated signaling pathways in vivo in the ovary which produces estrogen and eggs. Thus, our studies may lead to developing novel FSH-based therapies to preserve and enhance ovarian function in women.

PI_NAMEs: KUMAR, T. RAJENDRA  (contact)

PROGRAM_OFFICER_NAME: TAYMANS, SUSAN

PROJECT_TERMS: Age;age related;aged;Aging;Anterior Pituitary Gland;Antibodies;Antral;Binding;Biochemical;Biological Assay;Biology of Aging;Cell Culture Techniques;Cell Line;cofactor;Collaborations;Complex;Coupled;Culture Techniques;Data;design;egg;Endocrinology;Estrogens;Estrus;experimental study;Expression Profiling;Female;Follicle Stimulating Hormone;Follicle Stimulating Hormone Receptor;folliculogenesis;Foundations;Gene Expression;Gene Expression Profile;Genes;Genetic Engineering;Genetic Models;Germ Cells;Glycoproteins;glycosylation;Goals;Gonadotropins;granulosa cell;Growth;Growth and Development function;GTP-Binding Proteins;Heterogeneity;hormonal signals;Hormone Responsive;Hormones;Human;improved;In Vitro;in vivo;in vivo evaluation;Individual;Infertility;insight;Knockout Mice;Knowledge;Ligands;Link;Luteinizing Hormone;Mammalian Cell;Mass Spectrum Analysis;Mediating;Menopause;Menstrual cycle;Methods;Mission;Molecular;mouse genetics;mouse model;Mus;National Institute of Child Health and Human Development;novel;novel therapeutics;old mice;oocyte quality;Oogenesis;Ovarian;Ovarian aging;Ovarian Follicle;Ovarian Granulosa Cell;Ovarian Stimulations;Ovary;Pattern;pharmacologic;Phosphoproteins;phosphoproteomics;Pituitary Gland;Polysaccharides;Postmenopause;Preparation;preservation;Production;protein complex;protein expression;Proteins;Proteomics;Protocols documentation;receptor;Receptor Mediated Signal Transduction;Receptor Signaling;receptor-mediated signaling;Recombinant Follicle Stimulating Hormone;Recombinants;recruit;Regulation;reproductive;reproductive senescence;response;Role;Signal Pathway;Signal Transduction;Signal Transduction Pathway;Specificity;sugar;Testing;Thyrotropin;transcriptome sequencing;Variant;Woman;women's treatment;young woman

PROJECT_TITLE: FSH Glycoforms and Ovarian Signaling Pathways

STUDY_SECTION: CMIR

STUDY_SECTION_NAME: Cellular, Molecular and Integrative Reproduction Study Section[CMIR]


NIH_SPENDING_CATS: Cardiovascular;Diabetes;Heart Disease

ORG_CITY: MORGANTOWN

ORG_NAME: WEST VIRGINIA UNIVERSITY

ORG_STATE: WV

PHR: PROJECT NARRATIVE Type 2 diabetes mellitus incidence has increased dramatically, yet the prognosis for many of these subjects is poor, impacting healthcare costs, substantially. The proposed experiments are relevant to public health because they will enhance our understanding of the pathogenesis of diabetes-induced heart failure and provide information regarding targets for preventive and therapeutic interventions that will aid in the treatment of diabetes mellitus in the type 2 diabetic patient. Thus, the proposed research is relevant to the NIH’s mission that pertains to the pursuit of fundamental knowledge to extend healthy life and reduce the burden of illness.

PI_NAMEs: HOLLANDER, JOHN M (contact)

PROGRAM_OFFICER_NAME: WONG, RENEE P

PROJECT_TERMS: Address;Architecture;biological adaptation to stress;Biological Assay;burden of illness;Cardiac;Cardiovascular system;Cessation of life;db/db mouse;Development;Diabetes Mellitus;diabetes pathogenesis;diabetic;diabetic patient;Disease;Evaluation;experimental study;Functional disorder;Genome;Health Care Costs;Heart;Heart failure;Human;Impairment;Incidence;Inner mitochondrial membrane;insight;Knowledge;Life;Location;Maintenance;Mission;Mitochondria;mitochondrial dysfunction;mitochondrial heat shock protein 70;Mitochondrial Matrix;Mitochondrial Proteins;Modeling;Molecular;Molecular Conformation;Motor;mouse model;Mus;Myocardial dysfunction;Non-Insulin-Dependent Diabetes Mellitus;novel;Nuclear;Nuclear Import;Nuclear Proteins;Outcome;Outer Mitochondrial Membrane;overexpression;Pathway interactions;Patients;Peptide Hydrolases;Performance;preventive intervention;Process;Prognosis;protein aggregation;Protein Import;Proteins;Proteomics;proteostasis;Public Health;Research;Role;Set protein;Site;Stress;Structure;Testing;therapeutic development;Therapeutic Intervention;Type 2 diabetic;United States National Institutes of Health;Work

PROJECT_TITLE: Role of Protein Import in the Development of the Diabetic Heart

STUDY_SECTION: MPPB

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology B Study Section[MPPB]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Heart Disease;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_NAME: METHODIST HOSPITAL RESEARCH INSTITUTE

PHR: PROJECT NARRATIVE Atrial fibrillation, the most common cardiac arrhythmia in adults, is associated with increased morbidity and mortality. Activation of neuronal centers within the heart has been proposed to contribute to atrial fibrillation initiation and development. This application aims to elucidate how alterations in cardiac nerves increase susceptibility to atrial fibrillation.

PI_NAMEs: ALTAMIRANO, FRANCISCO ;VALDERRABANO, MIGUEL  (contact)

PROGRAM_OFFICER_NAME: SOPKO, GEORGE

PROJECT_TERMS: Ablation;Acute;Adult;Affect;Afferent Neurons;Animal Model;Animals;antagonist;Apnea;Arrhythmia;Atrial Fibrillation;Atrial Function;Automobile Driving;Autonomic nervous system;Basic Science;Blood;Blood Circulation;Blood specimen;Blood Vessels;canine model;Canis familiaris;Cardiac;Cardiac ablation;Cardiac Myocytes;cardiac tissue engineering;Chronic;Chronic Disease;Clinical assessments;Clinical Sciences;Clinical Trials;Coculture Techniques;Congestive Heart Failure;Coronary Circulation;Coronary sinus structure;Data;Dementia;Development;Diagnostic;diagnostic tool;Economic Burden;effective therapy;Electrophysiology (science);Engineering;Epidemic;FDA approved;Ganglia;Gene Expression;Genomics;Goals;Guidelines;healthcare burden;Heart;Heart Atrium;Heart failure;Human;human induced pluripotent stem cells;human pluripotent stem cell;improved;innovation;Innovative Therapy;insight;Knowledge;Longevity;Maintenance;Measures;Mediating;Methods;MicroRNAs;Molecular;Morbidity - disease rate;mortality;Myocardial;Nerve;neural;Neurons;neuroregulation;novel;Output;paracrine;Pathogenesis;Patients;Peptide Initiation Factors;peripheral blood;Play;Positioning Attribute;Predisposition;Prevalence;prevent;Prevention strategy;Procedures;Recurrence;Refractory;Reporting;Research;Research Priority;response;Risk;Risk Factors;Role;Route;Sampling;sensory system;Sleep Apnea Syndromes;stroke risk;Substance P;Syncope;System;targeted treatment;Technology;temporal measurement;Testing;Therapeutic;Tissues;treatment strategy;United States National Institutes of Health;Veins

PROJECT_TITLE: Cardiac Autonomic Activation In Atrial Fibrillation Triggers And Substrate


NIH_SPENDING_CATS: Bioengineering;Neurosciences

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative Information in the nervous system is relayed at synapses, where neurotransmitter is released with great precision from a presynaptic terminal on to a post-synaptic cell via the fusion of membrane bound synaptic vesicles with the cell membrane. The components of these vesicles are subsequently retrieved and recycled for reuse. This grant aims to understand how fusion and retrieval of vesicles influences membrane tension in these small structures and conversely how the speed with which the cell membrane flows influences synaptic function. PHS 398/2590 (Rev. 06/09) Page Continuation Format Page

PI_NAMEs: KARATEKIN, ERDEM  (contact);MACHTA, BENJAMIN BROOKS;ZENISEK, DAVID PAUL

PROGRAM_OFFICER_NAME: MATOS GALICIA, HEIDI YANICE

PROJECT_TERMS: Adrenal Glands;Area;Behavior;Binding;Biological Assay;Bipolar Neuron;Cell membrane;cell motility;Cell surface;Cells;Cellular biology;Charge;Chromaffin Cells;confocal imaging;Coupled;Coupling;Cytoskeleton;Drops;Electric Capacitance;Electron Microscopy;Electrophysiology (science);Endocytosis;Endocytosis Inhibition;Exocytosis;experimental study;F-Actin;Feedback;Fishes;Fluorescence Microscopy;Grant;Intervention;Knowledge;laser tweezer;live cell imaging;Maps;Measurement;Measures;Membrane;Membrane Fusion;Membrane Potentials;Methods;Modeling;Molecular;Nature;Nerve;Nervous System;Neuroendocrine Cell;neuronal cell body;Neurons;Neurotransmitters;optic tweezer;Optics;Osmosis;Pattern;pharmacologic;postsynaptic;presynaptic;presynaptic neurons;Presynaptic Terminals;Process;Property;Recovery;Recycling;Regulation;Reporting;Resistance;Resolution;response;retinal bipolar neuron;Retrieval;Signal Transduction;Site;Slide;spatiotemporal;Speed;Structure;Synapses;synaptic function;Synaptic Membranes;Synaptic Transmission;Synaptic Vesicles;System;Testing;Thinness;trafficking;Tube;ultra high resolution;Vesicle;viscoelasticity;Visualization;voltage;Work;Zebrafish

PROJECT_TITLE: Dynamics of membrane tension and synaptic vesicle recycling

STUDY_SECTION: BPNS

STUDY_SECTION_NAME: Biophysics of Neural Systems Study Section[BPNS]


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Liver Disease;Nutrition

ORG_CITY: DETROIT

ORG_DEPT: GENETICS

ORG_NAME: WAYNE STATE UNIVERSITY

PHR: Project Narrative  Non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes are two major metabolic disorders that affect up to 30% of the population in the United States. In this project, we will characterize a newly-identified metabolic regulator, named mitochondrial NAD kinase (MNADK), which plays key roles in preserving energy homeostasis and insulin sensitivity and thus mitigating the risk of NAFLD and type 2 diabetes caused by overnutrition. The proposed studies on the function and mechanism of MNADK in metabolism will have important implications in the prevention and treatment of human metabolic disease.

PI_NAMEs: ZHANG, KEZHONG ;ZHANG, REN  (contact)

PROGRAM_OFFICER_NAME: LYNCH, CHRISTOPHER

PROJECT_TERMS: Acetylation;Address;Affect;Anabolism;Antioxidants;Bioinformatics;burden of illness;Carnitine;cofactor;Development;Electrons;Energy Metabolism;Enzymes;Equilibrium;Fatty Liver;Generations;Genes;Genetic Transcription;Genetically Engineered Mouse;Goals;Hepatic;High Fat Diet;Homeostasis;Human;in vivo;Insulin Resistance;insulin sensitivity;Knockout Mice;Knowledge;Link;Liver;Liver Mitochondria;Lysine;Maintenance;Mechanics;Metabolic;Metabolic Diseases;Metabolism;Mitochondria;Mitochondrial Diseases;mitochondrial membrane;Modification;Molecular;Mus;Names;new therapeutic target;Nicotinamide adenine dinucleotide;non-alcoholic fatty liver disease;Non-Insulin-Dependent Diabetes Mellitus;nonalcoholic steatohepatitis;novel;Nutritional;Organelles;Overnutrition;Oxidation-Reduction;Pathology;Pathway interactions;Patients;Phenocopy;Phosphorylation;Phosphotransferases;Physiology;Plasma;Play;Population;preservation;prevent;Prevention;Production;Protein Acetylation;Protein Kinase;Protein S;reconstitution;Reducing diet;Repression;Research;Resistance;risk mitigation;Role;Shapes;Signal Transduction;Sirtuins;Stress;Symptoms;Testing;United States

PROJECT_TITLE: Mitochondrial NAD kinase: function and mechanism in metabolism


ORG_CITY: NASHVILLE

ORG_NAME: VETERANS HEALTH ADMINISTRATION

ORG_STATE: TN

PHR: Since 1999, 9% of all Veterans nationwide have been diagnosed with skin cancer. Unlike other cancer types, patients will often develop multiple skin cancers, and half of skin cancer-related deaths occur among those with 10 or more skin cancers, and these patients with 10 or more skin cancers have a 25% risk of metastasis. Skin cancer risk is thus heterogeneous, but little progress has been made in determining which patient will develop numerous skin cancers. This study will address the critical knowledge gap of how to identify a priori Veterans at high risk of skin cancer morbidity and mortality, starting with a high-incidence population. Organ transplant recipients (OTR) have up to 100-fold greater rates of skin cancer than non-OTR. We will examine clinical pharmacogenetic, and genomic factors associated with the development of 10 or more skin cancers within 10 years after transplant. These factors can provide clues to the relative importance of mechanisms of carcinogenesis of skin cancer and have the potential to be generalizable to the broader Veteran population.

PI_NAMEs: WHELESS, LEE E (contact)

PROJECT_TERMS: Address;Affect;Azathioprine;Basal cell carcinoma;biobank;Bioinformatics;bioinformatics infrastructure;cancer risk;cancer type;Carcinogenesis Mechanism;career development;Caring;Cessation of life;Clinical;cohort;cost estimate;Cyclosporine;Cytochrome P450;Data;Data Sources;Dermatology;Development;Diagnosis;Disease;DNA;DNA Repair;DNA Repair Gene;Environment;Exposure to;Funding;Genetic;genetic association;genetic epidemiology;genetic risk factor;genetic variant;Genomics;Genotype;Goals;hands-on learning;Healthcare Systems;High Prevalence;high risk;Hospitals;Immunosuppression;Immunosuppressive Agents;improved;Incidence;Individual;Informatics;Infrastructure;Institution;International;Keratinocyte cancer;Knowledge;learning strategy;Logistic Models;Malignant Epithelial Cell;Malignant Neoplasms;Measures;Mentors;Metabolism;military veteran;Morbidity - disease rate;mortality;Neoplasm Metastasis;neoplasm registry;organ transplant recipient;Organ Transplantation;Patients;Pattern;personalized management;Pharmaceutical Preparations;Pharmacogenetics;Pharmacogenomics;Phenotype;Physicians;Population;precision medicine;Primary Prevention;programs;prospective;rare variant;Records;Reporting;Risk;Role;Scientist;Skin Cancer;Squamous cell carcinoma;study population;Sun Exposure;sun protection;Sunburn;Tacrolimus;Tennessee;Testing;thiopurine;Time;Training;Transferase;transplant centers;Transplantation;United States;Variant;Veterans

PROJECT_TITLE: Identifying clinical and genetic factors for risk of multiple skin cancers in organ transplant recipients


ORG_CITY: WEST HAVEN

ORG_NAME: VA CONNECTICUT HEALTHCARE SYSTEM

PHR: There is an urgent need to develop more effective medications for addictive and psychiatric disorders, especially for veterans with these disorders. This Career Development Transition Award will help VA psychiatric researchers to invest in their research activities, while also participating in clinical care activities. This award will also allow them to participate in training activities to develop more effective treatments for addictive and psychiatric disorders.

PI_NAMEs: YOON, GIHYUN  (contact)

PROJECT_TERMS: addiction;Alcohol consumption;alcohol use disorder;antidepressant effect;Applications Grants;Area;Attention;Award;Biometry;Buprenorphine;Clinical;clinical care;clinical development;clinical practice;Clinical Research;clinical translation;Clinical Trials;Cognitive remediation;Collaborations;Communities;cost;Data;design;Disease;donepezil;double-blind placebo controlled trial;drug discovery;effective therapy;Eszopiclone;Excitatory Amino Acid Antagonists;Funding;gabapentin;Goals;Growth and Development function;High Prevalence;Human;Injectable;innovation;Insulin;Intervention;Investments;K-Series Research Career Programs;Ketamine;Lead;Legal patent;Major Depressive Disorder;Mental Depression;Mental disorders;Mental Health;military veteran;Mission;Morbidity - disease rate;mortality;N-Methylaspartate;Naltrexone;neuroimaging;Neurosciences;novel;novel strategies;Opioid Antagonist;Opioid Receptor;opioid use disorder;Paper;Patients;Pharmaceutical Preparations;Pharmacogenomics;pharmacologic;Pilot Projects;Policies;Post-Traumatic Stress Disorders;pre-clinical research;preventive intervention;Protocols documentation;Psychiatrist;Publishing;Randomized;Research;Research Activity;Research Methodology;Research Peer Review;Research Personnel;Research Priority;Research Project Grants;Research Technics;Research Training;Risk;Sleeplessness;Substance abuse problem;suicidal;Suicide prevention;Targeted Research;Testing;Therapeutic;Time;Training Activity;Transition Career Development Award (K22);Translating;Translational Research;Trazodone;United States National Institutes of Health;Universities;Veterans;Wages

PROJECT_TITLE: CSR&D Research Career Development Transition Award Application


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Lung;Lung Cancer

ORG_CITY: RICHMOND

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: PROJECT NARRATIVE Until now, researchers have focused on examining the genetic mutations that drive lung cancer. At present, thanks to innovative sequencing technologies and computational tools, it is possible to investigate the molecular mechanisms that trigger lung cancer more deeply. By leveraging these modern tools, we aim to study the altered non-coding RNA post-transcriptional modifications, specifically A-to-I editing, in lung cancer progression and drug resistance with the scope of identifying new molecular targets and possibly new future therapies.

PI_NAMEs: ACUNZO, MARIO  (contact)

PROGRAM_OFFICER_NAME: MAAS, STEFAN

PROJECT_TERMS: Adenosine;Affect;Apoptosis;Asian population;Bioinformatics;Biological;Cancer Biology;Cancer cell line;cancer drug resistance;Cancer Etiology;Cancer Patient;Cancerous;Cell Line;Cells;Cessation of life;Chemoresistance;Circulation;Code;combat;computerized tools;Coupled;Dedications;Disease;Disease Progression;DNA Sequence Alteration;DRADA2b protein;Drug resistance;dsRNA adenosine deaminase;Epidermal Growth Factor Receptor;Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor;Event;Extracellular Signal Regulated Kinases;Future;Gefitinib;gene repression;Genes;Genetic Transcription;Glioblastoma;Human Genome;in vivo;innovation;Inosine;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of urinary bladder;Malignant Neoplasms;malignant stomach neoplasm;MAPK3 gene;member;Messenger RNA;MET gene;MicroRNAs;Modernization;Modification;Molecular;Molecular Target;mouse model;mRNA Precursor;mutant;Mutate;Mutation;Names;next generation sequencing;Non-Small-Cell Lung Carcinoma;novel;novel therapeutics;Nucleotides;objective response rate;Pathogenesis;Pathway interactions;patient response;Patients;Pharmaceutical Preparations;Phenotype;Play;Positioning Attribute;Post-Transcriptional RNA Processing;posttranscriptional;Protein Family;Receptor Protein-Tyrosine Kinases;Regulation;Reporting;Repression;Research Personnel;Resistance;Resistance development;response;RNA;RNA Editing;RNA Primary Transcript;Role;Signal Repression;Signal Transduction;Somatic Mutation;Structure;Structure of parenchyma of lung;Technology;Testing;Therapeutic Uses;therapy development;Tissues;tool;transcriptome;transcriptome sequencing;Transfection;tumor progression;Tyrosine Kinase Inhibitor;Untranslated RNA

PROJECT_TITLE: The Role of Non-Coding RNA Editing in MET Signaling in NSCLC

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 2 Study Section[MCT2]


ORG_CITY: SAN DIEGO

ORG_NAME: VA SAN DIEGO HEALTHCARE SYSTEM

ORG_STATE: CA

PHR: The proposed CDA-2 will provide Dr. Malaktaris with the training and data to advance research aimed at improving psychological comorbidities and chronic pain (CP) disability among Veterans. The proposed study will include a randomized controlled trial to investigate the efficacy of Cognitively-Based Compassion Training for CP with Psychological Comorbidity (CBCT-CP+) compared to Health Education while Living with Pain (H.E.L.P.) using a sample of 126 Veterans with comorbid mental health symptoms and CP. This will be the first study of a compassion meditation intervention targeting comorbid mental health symptoms and CP disability within the VA, which would further the VA's commitment to improving the mental health and well-being of Veterans detailed in the 2018-2024 VHA Strategic Plan. Results from this study will directly inform patient care among Veterans with chronic pain and psychological comorbidity, and will be used to inform development of future clinical trial and implementation studies that seek to improve the lives and functioning of Veterans.

PI_NAMEs: MALAKTARIS, ANNE  (contact)

PROJECT_TERMS: Affect;Aftercare;Anger;Anxiety;Anxiety Disorders;anxiety symptoms;Area;Attention;Biometry;career;Caring;Chronic;chronic pain;chronic pain management;chronic painful condition;Clinic;Clinical;clinical effect;clinical implementation;clinical practice;Clinical Trials;Cognitive;Cognitive Therapy;comorbidity;comparison control;Compassion;Complementary Health;Complex;Control Groups;cost;Data;Data Analyses;Depressive disorder;depressive symptoms;Development;disability;Disease;Drops;economic cost;Educational Status;efficacy evaluation;Enrollment;epidemiology study;evidence base;experience;Feeling suicidal;follow-up;Future;Goals;Health;Health Care Costs;Health education;health related quality of life;Healthcare Systems;Immune response;implementation study;improved;Institution;Integrative Medicine;interest;Intervention;Intervention Studies;Lead;Life;Manuals;medical schools;Meditation;Mental Depression;Mental Health;Mentors;Mentorship;Mind-Body Intervention;mindfulness;Musculoskeletal;Musculoskeletal Pain;negative affect;negative mood;Non-Malignant;novel;Opioid;opioid misuse;Outcome;Pain;pain catastrophizing;Pain interference;Pain management;Pain Measurement;pain relief;Patient Care;Patients;Personal Satisfaction;Pharmaceutical Preparations;physical conditioning;Physical Function;Policies;Population;positive emotional state;Post-Traumatic Stress Disorders;Protocols documentation;psychoeducation;psychologic;psychological distress;psychosocial;Psychotherapy;Public Health;Quality of life;Randomized, Controlled Trials;recruit;reducing suicide;Reporting;Research;Research Personnel;Safety;Sampling;satisfaction;scaffold;Scientist;Severities;Site;social;Social Functioning;societal costs;Strategic Planning;stress reduction;suicidal risk;Suicide;Suicide prevention;Symptoms;Syndrome;Theoretical model;Training;training opportunity;treatment effect;Treatment outcome;treatment response;trial design;underserved area;Veterans;Veterans Health Administration;Work

PROJECT_TITLE: Efficacy of Mind-Body Approaches for the Treatment of Chronic Pain with Psychological Comorbidity


NIH_SPENDING_CATS: Congenital Structural Anomalies;Digestive Diseases;Genetics;Infant Mortality;Lung;Nutrition;Pediatric;Rare Diseases

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: The diaphragm is an essential mammalian skeletal muscle, as it is vital for respiration and serves as a barrier between the thoracic and abdominal cavities. Development of the diaphragm requires the integration of multiple tissues that derive from several embryonic sources, and defects in diaphragm development are the cause of congenital diaphragmatic hernia (CDH) a common birth defect (1 in 3000 births) that results in severe morbidity and 50% mortality. Our research will elucidate the genetic, molecular, cellular, and environmental mechanisms regulating development of the diaphragm and CDH and provide important insights into CDH's phenotypic and clinical variability.

PI_NAMEs: KARDON, GABRIELLE  (contact)

PROGRAM_OFFICER_NAME: TOYAMA, REIKO

PROJECT_TERMS: Abdominal Cavity;Affect;All-Trans-Retinol;Alleles;Birth;Cells;Cervical;Characteristics;Clinical;Code;Complex;conditional mutant;Congenital Abnormality;Congenital diaphragmatic hernia;Connective Tissue;Data;Defect;Development;Diet;Dose;Embryo;Embryonic Structures;Enhancers;Environmental Monitoring;Etiology;Extracellular Matrix;Fibroblasts;Frequencies;GATA4 gene;Genes;Genetic;Genetic study;Genotype;Heart;Hernia;Human;Human Characteristics;Human Genetics;insight;Introns;Left;Location;Modeling;Molecular;Morbidity - disease rate;mortality;mouse genetics;Mouse Strains;Mus;Muscle;Mutagenesis;Mutant Strains Mice;Mutation;novel;Outcome;Patients;Penetrance;Perinatal mortality demographics;Phenotype;Play;Prevalence;Proliferating;Protocols documentation;Regulation;Reporter;Research;Respiration;Respiratory Diaphragm;Retinoids;Role;Series;Severities;Signal Transduction;Skeletal Muscle;Somites;Source;Teratogens;Testing;Thoracic cavity structure;Tissues;Tretinoin;Vitamin A;Vitamin A Deficiency

PROJECT_TITLE: Genetic and Environmental Regulation of Diaphragm Development and Congenital Diaphragmatic Hernias

STUDY_SECTION: SMEP

STUDY_SECTION_NAME: Skeletal Muscle and Exercise Physiology Study Section[SMEP]


NIH_SPENDING_CATS: Digestive Diseases;Hematology;Liver Disease;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn

ORG_CITY: OMAHA

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: Project Narrative Anemia is a nearly universal diagnosis in preterm infants and is associated with increased morbidity and mortality worldwide. When severe enough to be treated with RBC transfusion, critical adverse effects can be seen; one such consequence is necrotizing enterocolitis (NEC), an inflammatory bowel necrosis of preterm infants characterized by monocyte infiltration and activation. In this application, the investigators propose sequential studies to investigate the ontogeny of implicated monocytes, the mechanism(s) involved in their recruitment, and potential strategies to prevent their activation in the progression to NEC.

PI_NAMEs: KRISHNAN, MOHAN KUMAR (contact)

PROGRAM_OFFICER_NAME: HAILU, BENYAM

PROJECT_TERMS: Adoptive Cell Transfers;Adult;Adverse effects;Anemia;Antibody Therapy;Attenuated;Awareness;Bacterial Translocation;Bone Marrow;Caring;Cells;Communication;Data;Diagnosis;Dose;Embryo;Endothelium;Enterobacteria phage P1 Cre recombinase;Environment;Epithelium;Erythropoietin;fetal;Fetus;Growth;Gut Mucosa;gut-liver axis;Hematopoiesis;Heme;Hepatic;Human;Immunity;In Situ;inducible Cre;Infiltration;Inflammatory;Inflammatory Response;inhibitor;Injury;innate immune mechanisms;Intervention;intestinal hypoxia;intestinal injury;Intestinal Mucosa;Intestinal permeability;Intestines;intravenous administration;Investigation;ITGAM gene;Leaky Gut;Leukocytes;Lipopolysaccharides;Liver;Macrophage;Maps;Medical;migration;monocyte;Morbidity - disease rate;mortality;mouse model;Mucous Membrane;Mus;Myelogenous;Myeloid Cells;Natural Immunity;Necrosis;necrotic tissue;Necrotizing Enterocolitis;Neonatal;Neonatal Anemia;neonatal mice;neonate;novel;Oxygen;Pathologic;Peptides;Phenotype;Physiological;Population;Portal vein structure;postnatal;pre-clinical;Pregnancy;Premature Infant;preterm newborn;prevent;Probability;receptor;recruit;Research Personnel;response;Risk;Role;Sampling;Signal Transduction;Site;Source;Spleen;Surface;Testing;therapeutic target;therapeutically effective;Transact;Transfusion;Venous blood sampling

PROJECT_TITLE: Liver-Gut Axis in Neonatal Anemia and Its Role in RBC Transfusion Associated Gut Injury

STUDY_SECTION: HTBT

STUDY_SECTION_NAME: Hemostasis, Thrombosis, Blood Cells and Transfusion Study Section[HTBT]


NIH_SPENDING_CATS: Cancer;Genetics;Skin Cancer

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative The cell cycle regulator p16 is deleted or silenced in >30-40% of melanomas, but no current treatment strategies exist to target this patient population. In this study, we will investigate the role of p16 loss in upregulating pro- tumorigenic nucleotide metabolism by a newly-defined ATR-mTORC1 axis and evaluate inhibition of this signaling pathway in p16-low melanomas alone or in combination with current standard-of-care treatment. The results will have a direct impact on the development of novel therapeutic strategies to obtain a therapeutic response in melanoma patients with low p16 expression.

PI_NAMEs: AIRD, KATHERINE MARIE (contact)

PROGRAM_OFFICER_NAME: WILLIS, KRISTINE AMALEE

PROJECT_TERMS: Address;Benign;BRAF gene;Bypass;cancer cell;cancer type;Cell Cycle;Cell Cycle Arrest;Cell Cycle Inhibition;Cell Line;Cells;Couples;Data;Development;Disease;Down-Regulation;enzyme pathway;Event;experimental study;Future;Goals;Human;improved;inhibitor;inorganic phosphate;insight;Isomerase;knock-down;Knowledge;Malignant Neoplasms;Mediating;Mediator;melanocyte;Melanoma;Melanoma Cell;Melanoma patient;melanomagenesis;Metabolic;Metabolism;Modeling;Molecular;mutant;Mutation;Nevus;new therapeutic target;novel;novel therapeutic intervention;novel therapeutics;Nucleosides;Nucleotide Biosynthesis;nucleotide metabolism;Nucleotides;Oncogene Activation;Oncogenes;Pathway interactions;patient derived xenograft model;patient population;patient subsets;Patients;Pentosephosphate Pathway;Phenotype;Phosphorylation;Publishing;replication stress;Repression;Research;Resistance;Ribose;Role;senescence;Signal Pathway;Signal Transduction;Skin;standard of care;stress tolerance;Supplementation;synergism;targeted treatment;Testing;Therapeutic;therapy outcome;Translations;treatment response;treatment strategy;TSC1 gene;Tumor Suppressor Proteins;tumorigenesis;tumorigenic;Up-Regulation

PROJECT_TITLE: Investigating p16 Loss in Pro-tumorigenic Metabolism

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OBT-D(02)M]