ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Digestive Diseases;Orphan Drug;Pancreatic Cancer;Patient Safety;Prevention;Rare Diseases

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: Project Narrative The proposed study is highly relevant to public health because chronic pancreatitis, despite its relatively low incidence rate, is associated with significant disease burden and poor quality of life—worse than many other chronic conditions. Pancreatic cancer is the fourth largest killer among all cancers, yet there is no effective prevention or detection method at a curable stage. Understanding the complex relationships between chronic pancreatitis, new-onset diabetes, and pancreatic cancer is key to finding effective interventions, making such knowledge imperative for public health.

PI_NAMEs: LI, LIANG ;MAITRA, ANIRBAN ;YUAN, YING  (contact)

PROGRAM_OFFICER_NAME: UNALP-ARIDA, AYNUR

PROJECT_TERMS: Address;Adherence;Adopted;Amendment;Ancillary Study;Biological Specimen Banks;biomarker development;biomarker discovery;biomarker validation;burden of illness;Chronic;chronic pancreatitis;clinical center;Clinical Trials Data Monitoring Committees;Collaborations;Communication;Complex;Contracts;cost;Data;Data Collection;data communication;Data Coordinating Center;data management;Data Management Resources;data quality;data submission;design;detection method;Development;Diabetes Mellitus;Discipline;disorder prevention;Documentation;Educational workshop;effective intervention;Electronic Mail;Evaluation;follow-up;Incidence;Infrastructure;innovation;Institution;Institutional Review Boards;Intervention;Investigation;Knowledge;Leadership;Logistics;Longitudinal cohort study;Maintenance;Malignant neoplasm of pancreas;Malignant Neoplasms;Manuals;Manuscripts;meetings;Methodology;Monitor;novel;operation;organizational structure;Participant;Patients;Persons;Phase;Policies;Preparation;Prevention;Procedures;protocol development;Protocols documentation;Public Health;quality assurance;Quality Control;Quality of life;Reporting;Research;Research Design;Research Infrastructure;Research Personnel;Rest;sample collection;Scientist;screening;Secure;service providers;Site;Statistical Data Interpretation;success;symposium;System;Testing;Therapeutic Trials;Time;Training;United States National Institutes of Health;Update;validation studies;web site;working group

PROJECT_TITLE: Consortium for the Study of Chronic Pancreatitis, Diabetes and Pancreatic Cancer: Coordinating and Data Management Center (CSCPDPC-CDMC)


ADMINISTERING_IC: AG

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging

ORG_CITY: ANN ARBOR

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PI_NAMEs: YUNG, RAYMOND L (contact)

PROJECT_TITLE: Leadership/Administrative Core


NIH_SPENDING_CATS: Aging;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Health Services;Liver Disease;Neurodegenerative;Prevention

PI_NAMEs: MODY, LONA  (contact)

PROJECT_TERMS: African American;age related changes;age-related disease;aged;Aging;Alzheimer's Disease;American;Antibiotics;Award;Behavioral;Biological;Biological Markers;Biology;Biomechanics;Biostatistics Core;Capsicum;Cardiovascular system;care outcomes;career development;Cirrhosis;Clinical;Clinical Services;Collaborations;college;comorbidity;Core Facility;Data;delivered meals;design;diabetes self-management;Discipline;Disease-Modifying Second-Line Drugs;education research;Engineering;Faculty;functional status;Funding;Genetic;Geriatrics;Goals;Grant;Health;Health Policy;Health Services Research;Healthcare Systems;Hepatic Encephalopathy;Home;human subject;Immune;improved;Infection prevention;Inflammation;Inflammation Mediators;innovation;Interdisciplinary Study;interest;Intervention;Leadership;leadership development;Measures;medical schools;member;men;Mentors;Mentorship;Metabolic;Michigan;Modeling;mouse model;Non-Insulin-Dependent Diabetes Mellitus;older adult;Outcome;Paper;Pathway interactions;patient oriented research;peer;Pharmaceutical Preparations;Pilot Projects;Population;pre-clinical;prevent;pro-aging;Productivity;programs;Proteins;Public Health Schools;Publishing;Randomized, Controlled Trials;recruit;Recurrence;Research;Research Activity;research and development;Research Design;Research Personnel;Research Project Grants;Research Proposals;research study;Research Support;Resources;Rheumatoid Arthritis;Rodent;School Nursing;Schools;Scientific Evaluation;Scientist;social;Social Work;success;System;Testing;translational approach;Translations;Universities;Work

PROJECT_TITLE: Pilot and Exploratory Studies Core


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Breast Cancer;Cancer;Women's Health Research

ORG_CITY: GAINESVILLE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Therapeutics effective against metastatic and drug resistant breast cancers are desperately needed to improve patient survival. The objective of the present project is to characterize the pharmacokinetic and pharmacodynamic properties and evaluate the safety of a new class of anticancer drugs, termed Disulfide bond Disrupting Agents (DDAs), and select an optimal candidate for future IND-enabling studies. DDAs are the first identified active site inhibitors of the protein disulfide isomerases ERp44, AGR2, and act through a unique mechanism involving downregulation of EGFR, HER2, and HER3 and activation of Death Receptors 4 and 5, resulting in selective killing of EGFR+ or HER2+ breast cancer cells.

PI_NAMEs: LAW, BRIAN K. (contact)

PROGRAM_OFFICER_NAME: COVELL, DAVID G

PROJECT_TERMS: Active Sites;advanced breast cancer;Advanced Malignant Neoplasm;Adverse effects;Affect;African American Women;Agonist;AGR2 gene;American;Animal Model;Animals;anti-cancer;Antineoplastic Agents;Apoptosis;Apoptotic;Autopsy;Binding;Biological Markers;biomarker validation;Blood Cell Count;Breast;Breast Cancer Cell;Breast Cancer Patient;breast cancer survival;cancer cell;cancer subtypes;cancer survival;carcinogenesis;CASP8 gene;Cell Death;Cell surface;Cessation of life;Chemicals;Client;Clinical;Clinical Trials;clinically relevant;Dependence;Disseminated Malignant Neoplasm;disulfide bond;Disulfides;dosage;Dose;Down-Regulation;Drug Kinetics;Drug resistance;Epidermal Growth Factor Receptor;ERBB2 gene;ERBB3 gene;Ethnic Population;Exhibits;Family;Formulation;Future;Health;Heterodimerization;Histologic;Human;IGF1R gene;improved;in vivo;Induction of Apoptosis;inhibitor;Kidney;Knock-out;Ligands;Link;Liver;Malignant Breast Neoplasm;Malignant Neoplasms;Mediating;Medicine;Metabolism;Modeling;Monitor;mortality;Mus;Muscle;Needle biopsy procedure;Neoplasm Metastasis;Normal Cell;Normal tissue morphology;Oncogenic;Oncoproteins;overexpression;Pathway interactions;patient stratification;Patients;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;pharmacologic;Plasma;preclinical efficacy;preclinical study;predictive marker;Preparation;prevent;Primary Neoplasm;Property;Protein Disulfide Isomerase;protein folding;Protein Inhibition;Proteins;Publishing;receptor;Receptor Protein-Tyrosine Kinases;Refractory;refractory cancer;Resistance;response;Role;Route;Safety;Sampling;Signal Transduction;Structure;targeted agent;Therapeutic;therapeutically effective;therapy resistant;TNFRSF10A gene;TNFRSF10B gene;Toxic effect;treatment effect;triple-negative invasive breast carcinoma;tumor;Tumor Escape;Tumor Necrosis Factor Receptor;Tumor Necrosis Factors;Up-Regulation;Woman;Work

PROJECT_TITLE: HER1-3 and Death Receptor protein folding as therapeutic vulnerabilities


NIH_SPENDING_CATS: Aging;Bioengineering;Networking and Information Technology R&D (NITRD);Prevention;Urologic Diseases

PI_NAMEs: ASHTON-MILLER, JAMES ANTHONY (contact)

PROJECT_TERMS: Affect;age-related disease;Aging;American;American Heart Association;Applications Grants;Award;bench to bedside;Biological Markers;Biomechanics;black men;Blood Vessels;Blood Volume;Calibration;Capsicum;Cardiac;career development;Collaborations;comorbidity;Computer Models;Computer Simulation;computerized data processing;Data;data acquisition;decubitus ulcer;design;Development;Diabetes Mellitus;Diagnosis;Disease;Economics;Elderly;Encephalopathies;Engineering;Equilibrium;Equipment;Excretory function;Extramural Activities;Extravasation;Faculty;fall injury;falls;Functional disorder;functional status;Geriatrics;Goals;Grant;Health;hip replacement arthroplasty;improved;Individual;Indwelling Catheter;Inflammation;insight;Institution;Interdisciplinary Study;interest;Internal Medicine;Intervention;invention;investigator training;Kidney Failure;Laboratory Research;Life Style;Liver Cirrhosis;mathematical model;Measurement;Measures;Mechanics;Mentored Clinical Scientist Development Program;Mentorship;Metabolic Diseases;Methods;microsensor;Mobility decline;Modeling;Modification;motion sensor;Non-Insulin-Dependent Diabetes Mellitus;novel;older adult;Older Population;older women;Outcome;Outcome Measure;Output;pathomechanics;Patients;Peer Review;pelvic organ prolapse;Physical activity;physical impairment;Physicians;Physiological;prevent;Prevention;processing speed;Productivity;programs;Ptosis;Renal function;Research;research clinical testing;Research Personnel;Research Project Grants;Risk Reduction;Self Management;Services;Severities;Smooth Muscle;Sodium;software systems;sphincter ani muscle structure;Striated Muscles;Structure;success;System;Technology Transfer;Testing;Time;Training;Urethra;Urethral sphincter;Urinary Incontinence;Urine;Validation;wearable device;wearable sensor technology

PROJECT_TITLE: Biomechanics Core


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: ROCHESTER

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF ROCHESTER

ORG_STATE: NY

PHR: Project Narrative The goal of this competitive renewal application of a 35 year T32 Predoctoral Training Program in Immunology is to build a mentorship-network based, autonomy motivated, and supportive educational program fostering trans-disciplinary, collaborative, and inclusive interactions that can support our trainees’ goals and enrich their scientific, professional and leadership competencies toward impactful biomedical research careers that will ultimately improve human health.

PI_NAMEs: GERBER, SCOTT ANDREW;ROBERT, JACQUES  (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TITLE: The T32 Predoctoral Training Program in Immunology (PTPI)

STUDY_SECTION: AITC

STUDY_SECTION_NAME: Allergy, Immunology, and Transplantation Research Committee[AITC]


NIH_SPENDING_CATS: Aging;Genetics;Nutrition

PI_NAMEs: MILLER, RICHARD A (contact)

PROJECT_TERMS: Adipose tissue;Adult;Age;aged;Aging;American;anti aging drug;Antioxidants;Award;Binding Proteins;biogerontology;Birds;Breeding;Caenorhabditis elegans;cancer cell;Capsicum;Cell Line;Collaborations;Consultations;Core Facility;Data;Development;Diet;Dietary Intervention;Disease;DNA Methylation;Dwarfism;Enzymes;epigenetic clock;extend lifespan;Extramural Activities;Faculty;fly;follow-up;Funding;Gene Expression Profile;Genes;Goals;Growth Hormone Receptor;Health;IGF1 gene;Incidence;indexing;Inflammation;Inflammatory;innovation;Institution;interest;Intestinal Polyps;late life;Leadership;life span;Link;Malignant Neoplasms;Melanoma;Messenger RNA;Metabolic;Mitochondria;Modeling;mouse model;mRNA Translation;Mus;mutant;Mutant Strains Mice;Mutation;neoplastic;novel;overexpression;overexpression analysis;Oxidation-Reduction;oxidative damage;Pathology;Pathway interactions;Pattern;Peptide Hydrolases;Pharmaceutical Preparations;Physiological;Primates;Professional Education;Proteins;rate of aging;Research;Research Personnel;Resources;Rodent;Rodent Model;Role;Scientist;serotonin receptor;Sirolimus;Students;System;Tamoxifen;Testing;Thermogenesis;thioredoxin reductase 2;Tissues;Training;transcriptome;Translations;Work

PROJECT_TITLE: Core Facility for Aged Rodents


NIH_SPENDING_CATS: Genetics;Infectious Diseases;Women's Health Research

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: PROJECT NARRATIVE Sex differences in outcomes following viral infections are well-described and may reflect sexual dimorphism in NK cell composition and effector function. This proposal will define how an X chromosome-linked epigenetic regulator, UTX, controls natural killer (NK) cell effector responses to viral infection and is responsible for NK cell sex differences. A deeper understanding of the cellular and molecular mechanisms of NK cell sex differences will lead to new insights into NK cell function and strategies for optimizing anti-viral immune responses.

PI_NAMEs: O'SULLIVAN, TIMOTHY E;SU, MAUREEN A (contact)

PROGRAM_OFFICER_NAME: JOFFE, AARON MICHAEL

PROJECT_TERMS: Ablation;Anti-viral Response;antiviral immunity;Apoptosis;Apoptotic;BCL2 gene;Binding;Biological Assay;Cell Count;Cell Maturation;Cell Physiology;cell type;Cell-Mediated Cytolysis;Cells;Chromatin;Chromatin Remodeling Factor;CRISPR/Cas technology;cytokine;Cytomegalovirus;Cytomegalovirus Infections;cytotoxic;cytotoxicity;Data;Development;differential expression;Disease;Disparity;Effector Cell;EP300 gene;Epigenetic Process;epigenomic profiling;Female;fitness;Gene Expression;Genes;Genetic Transcription;genomic locus;Genomics;Gonadal Hormones;Granzyme;Health;histone demethylase;Homeostasis;Hormones;Human;Immune;Immune response;Immunotherapy;Impairment;improved outcome;In Vitro;in vivo;Inflammatory;insight;Interferon Type II;Intervention;Knowledge;Link;Lymphocyte;male;Mammals;Mediating;Methyltransferase;Molecular;mouse model;Murid herpesvirus 1;Mus;Natural Killer Cells;new therapeutic target;Outcome;p300/CBP-Associated Factor;perforin;personalized therapeutic;Phenocopy;Positioning Attribute;Predisposition;Production;programs;recruit;Regulation;Resistance;response;Role;Sampling;sex;Sex Bias;Sex Chromosomes;Sex Differences;sexual dimorphism;System;Testing;Viral;Viral Cancer;Virus Diseases;women versus men;X Chromosome;X Inactivation

PROJECT_TITLE: Sex Differences in NK Cells Mediated by X-linked UTX

STUDY_SECTION: III

STUDY_SECTION_NAME: Innate Immunity and Inflammation Study Section[III]


NIH_SPENDING_CATS: Aging;Clinical Research

PROJECT_TERMS: Acceleration;Affect;Aging;American;Animals;Award;Basic Science;bench to bedside;Biological;Biological Specimen Banks;Capsicum;Clinical;clinical practice;Clinical Research;clinical translation;Clinical Trials;Cognitive;cognitive function;Collaborations;Communities;community engagement;comorbidity;Consultations;Data;Data Set;data sharing;Databases;Dimensions;disability;Disease;disorder risk;education research;Electronic Health Record;Ethnic Origin;Experimental Designs;Faculty;functional outcomes;functional status;Funding;Gerontology;Goals;Health;Health and Retirement Study;Health Surveys;Human;human subject;improved;Inflammation;Inflammation Mediators;Inflammatory;Infrastructure;Institutional Policy;Institutional Review Boards;Leadership;Logistics;Mediator;Mentors;Metabolic;Methods;Michigan;Minority;Modeling;Monitor;older adult;Outcome;Outcome Measure;Outcomes Research;Participant;Patient Self-Report;Play;population based;Predisposing Factor;Prevalence;Process;Race;recruit;Registries;Research;Research Activity;Research Personnel;Research Project Grants;Resources;Role;Safety;Sampling;Source;Subjects Selections;Symptoms;Techniques;Testing;Training;Translational Research;Translations;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Human Subjects and Assessment Core


PI_NAMEs: GALECKI, ANDRZEJ T (contact)

PROJECT_TERMS: Address;age-related disease;Aging;American;analytical method;Archives;Area;Biometry;Biostatistics Core;Capsicum;care recipients;career;Code;Collaborations;community center;comorbidity;Consultations;Data;Data Analyses;Data Collection;data management;Data Set;Databases;design;Development;Disease;education research;Elderly;Faculty;Fostering;Foundations;functional status;Future;genetic analysis;Gerontology;Goals;Health;Health and Retirement Study;Home;improved;Inflammation;instrument;Interdisciplinary Study;Intervention;late life;Literature;Long-Term Care;meetings;Mentors;Metabolic;Metabolism;Methodology;Methods;Michigan;Names;novel;older adult;Outcome;Persons;Population Research;Principal Investigator;Process;Productivity;Randomized;Recommendation;Recording of previous events;Research;research and development;Research Design;Research Personnel;Research Project Grants;research study;response;Rodent Model;Sampling;Schedule;Secondary to;Site;Software Tools;Statistical Models;Survey Methodology;Surveys;Techniques;Technology;Training;trend;Visualization;Writing

PROJECT_TITLE: Design, Data and Biostatistics Core


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: SAINT LOUIS

ORG_DEPT: BIOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PUBLIC HEALTH RELEVANCY STATEMENT / NARRATIVE Epigenetic modifications (the layer of chemical information sitting on top of the genome) that switch genes ‘on’ or ‘off’ play critical roles in many biological processes, including genome expression, genome integrity, development, environmental responses, and diseases. Its correct deposition and maintenance are critical for the development and function of cells, tissues, and organisms and are often disturbed in developmental disorders and diseases. The proposed research programs are relevant to public health because in-depth mechanistic knowledge of epigenetic regulation will lead to the development of innovative tools to correct aberrant epigenetic modifications and ultimately enable new applications for medicine and human health.

PI_NAMEs: ZHONG, XUEHUA  (contact)

PROGRAM_OFFICER_NAME: CHOW, CHI-WING

PROJECT_TERMS: Acceleration;Arabidopsis;Biochemical;Biological Process;Cell Physiology;Chemicals;Correlative Study;CRISPR/Cas technology;Cues;Deposition;Development;developmental disease;Disease;DNA Sequence;Engineering;Epigenetic Process;epigenetic regulation;epigenome;epigenome editing;Eukaryota;functional outcomes;Gene Expression;Genes;Genetic;Genome;genome integrity;genome-wide;Genomics;Health;Human;Imaging Techniques;innovation;Knowledge;live cell imaging;Maintenance;Mediating;Medicine;Modification;Molecular;Organism;Pathologic;Pattern;Phase Transition;Physiological;Play;programs;Proteomics;Public Health;Research;Resolution;response;Role;Shapes;Stress;Switch Genes;System;Technology;Tissues;tool

PROJECT_TITLE: Renewal: MIRA: Epigenetic regulation of genome integrity, environmental interaction, and inheritance

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Breastfeeding, Lactation and Breast Milk;Emerging Infectious Diseases;Infectious Diseases;Microbiome;Nutrition;Pediatric;Prevention

ORG_CITY: CHICAGO

ORG_NAME: LURIE CHILDREN'S HOSPITAL OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE The rapid spread of extended spectrum beta-lactamase producing Escherichia coli (ESBL E. coli) is a growing public health concern across the world. Neonates are an especially vulnerable population for both symptomatic disease and asymptomatic carriage of ESBL E. coli, due to their age and unique gut microbial composition and physiology. We now aim to utilize a murine model to gain insights into the impact of early life acquisition of ESBL E. coli on the developing gut microbiome, especially in the setting of varying nutritional intake and age of acquisition.

PI_NAMEs: ARSHAD, MEHREEN  (contact)

PROGRAM_OFFICER_NAME: BAQAR, SHAHIDA

PROJECT_TERMS: Adult;Age;age related;Animal Model;Antibiotics;Antimicrobial Resistance;Bacteremia;Biological;Birth;Calorimetry;Characteristics;Childhood;clinically relevant;Collaborations;colonization resistance;commensal bacteria;commensal microbes;Communicable Diseases;Communities;Culture Media;Development;Dietary Intervention;Disease;dysbiosis;Enterobacteriaceae;Environment;Escherichia coli;experimental study;Extended spectrum Beta lactamase producing Escherichia coli;Extended-spectrum β-lactamase;Feces;fitness;Genomics;Growth;gut colonization;gut microbiome;gut microbiota;Health Care Costs;high risk;high risk infant;Immune system;In Vitro;in vivo;infancy;Infant;Infant Development;infant gut microbiome;Infant Health;infant nutrition;infant outcome;Infection;insight;Intake;Integration Host Factors;Knowledge;Laboratories;Length of Stay;Life;Malnutrition;Meningitis;Metabolic;Metabolism;Metagenomics;Methods;Microbe;Microbial Physiology;microbiome;microbiome alteration;modifiable risk;Molecular;Morbidity - disease rate;mortality;mouse model;Multi-Drug Resistance;Mus;Neonatal;neonatal period;neonate;next generation sequencing;Nutrient;nutrition;Nutritional;Nutritional status;Pathogenesis;pathogenic Escherichia coli;Pediatric Hospitals;Perinatal transmission;Physiology;postnatal;Prevalence;prevent;Probiotics;Public Health;pup;Research Personnel;Resistance development;Ribosomal RNA;Risk;Risk Factors;Role;rRNA Genes;Shotguns;Testing;Time;Universities;Urinary tract infection;Vulnerable Populations;Wisconsin;Work

PROJECT_TITLE: Investigating the impact of ESBL E. coli colonization on infant microbiome

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IMII-U(01)]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE This research aims to develop technologies to engineer proteins with new functions, and to dissect functions of natural proteins in their cellular context by integrating genome-scale data with studies of molecular mechanism. We seek to advance practical applications in biomedical research and biological engineering, and to uncover principles of cellular regulation to lead to new ways to counteract misregulation in disease.

PI_NAMEs: KORTEMME, TANJA  (contact)

PROGRAM_OFFICER_NAME: GERSHENSON, ANNE

PROJECT_TERMS: Address;Allosteric Site;Area;Behavior;Biological;Biological Process;Biology;Biomedical Engineering;Biomedical Research;Biophysics;Bioremediations;cell growth regulation;Cell Physiology;Cells;cellular engineering;Data;design;Development;Diagnostic;Disease;Engineering;Future;Genetic;genetic regulatory protein;genome-wide;Geometry;Goals;Grant;Guanosine Triphosphate Phosphohydrolases;Maps;Measurement;metabolic engineering;Methods;Modeling;Molecular;Mutagenesis;Mutation;National Institute of General Medical Sciences;practical application;Protein Engineering;protein function;Proteins;Regulation;Research;response;Shapes;Signal Transduction;Signaling Molecule;Site;small molecule;System;Technology;Testing;Work

PROJECT_TITLE: Computational design of proteins and protein functions

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


ADMINISTERING_IC: MH

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Anxiety Disorders;Biotechnology;Brain Disorders;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Mental Health;Mental Illness;Prevention;Racial and Ethnic Minority Health Research;Serious Mental Illness

ORG_CITY: NEW YORK

ORG_DEPT: PSYCHIATRY

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Project Narrative Obsessive-compulsive disorder (OCD) is a debilitating psychiatric disorder, yet its etiology is largely unknown and treatment could be improved, and perhaps even personalized, if biological targets could be identified. Our goal in this study is to learn more about what precise genetic factors influence risk for OCD. We propose to do this by investigating both common and rare genetic variants in a large OCD cohort including samples of admixed and diverse ancestrally.

PI_NAMEs: CAPPI, CAROLINA  (contact)

PROGRAM_OFFICER_NAME: VAN'T VEER, ASHLEE VICTORIA

PROJECT_TERMS: Acceleration;Address;Algorithms;Architecture;Attention deficit hyperactivity disorder;autism spectrum disorder;Biological;Bipolar Disorder;cell type;Code;cohort;Collaborations;Collection;Communities;comparative;Complex;Data;Data Aggregation;Data Set;de novo mutation;Development;Diagnosis;Disabling;Disease;disorder risk;Ensure;Etiology;European ancestry;exome sequencing;Explosion;Faculty;Focus Groups;Functional disorder;Future;gene discovery;Gene Expression;Genes;Genetic;genetic architecture;Genetic Diseases;Genetic Research;Genetic Risk;Genetic study;genetic variant;Genetic Variation;genome wide association study;genome-wide;genomic data;Genomics;Genotype;Goals;Grant;improved;Inherited;insight;Intervention;Investigation;Knowledge;Laboratories;Latin American;Latinx;Latinx population;Lead;Learning;Manuscripts;Maps;medical specialties;Mental Depression;Mental disorders;Mentors;Meta-Analysis;Methods;multiple omics;Neurobiology;Neurons;novel therapeutics;Obsessive-Compulsive Disorder;Parents;Pathway interactions;Phase;Phenotype;polygenic risk score;Population;Population Heterogeneity;Positioning Attribute;Post-Traumatic Stress Disorders;programs;psychiatric genomics;psychogenetics;Reporting;Reproducibility;Research;Risk;risk sharing;risk variant;Role;Sample Size;Sampling;Schizophrenia;Scoring Method;Severities;skills;Symptoms;Techniques;tenure track;Training;Variant;Work;working group;Writing

PROJECT_TITLE: Genomics of OCD in Latin American Communities


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

ORG_STATE: PA

PHR: Project Narrative Neutrophils are crucial immune system cells that act as a first line of defense against infections, and an absence of neutrophils places patients at increased risk of death due to uncontrolled infection. We have identified a new genetic cause for severe congenital neutropenia (SCN), a rare disorder characterized by an inability to generate mature, functional neutrophils. Studying the mechanisms underlying this disorder will allow us to make significant advances into basic neutrophil biology, subsequently leading to new therapies aimed at both SCN patients and patients who have decreased neutrophil numbers in the setting of chemotherapy treatment.

PI_NAMEs: WARREN, JULIA THERESE (contact)

PROGRAM_OFFICER_NAME: WELNIAK, LISBETH A

PROJECT_TERMS: Address;Affect;Apoptosis;Area;Biogenesis;Bioinformatics;biological adaptation to stress;Biology;Biometry;Birth;Bone marrow failure;career development;CD34 gene;Cell model;Cells;cellular engineering;cellular transduction;Cessation of life;chemotherapy;Chronic;Clinical;cohort;Core Facility;CRISPR/Cas technology;Cytoplasmic Granules;Data;Defect;Disease;Educational workshop;Endoplasmic Reticulum;endoplasmic reticulum stress;Environment;Equilibrium;exome sequencing;experience;experimental study;Functional disorder;Genes;Genetic;Genetic Models;Genotype;Glycolysis;Goals;granulocyte;Granulopoiesis;Hematological Disease;Hematopoiesis;Heterozygote;HL-60 Cells;Homologous Gene;Human;Immune system;Impairment;Induction of Apoptosis;Infection;Inner mitochondrial membrane;insight;Institution;interest;Knock-out;Knowledge;Laboratories;Laboratory Research;Lentivirus;Link;Malignant - descriptor;Mediating;Mentors;Mentorship;misfolded protein;Missense Mutation;Mitochondria;Modeling;Molecular;Molecular Chaperones;Morphology;mortality risk;mutant;Mutate;Mutation;Myeloablative Chemotherapy;Myelogenous;Myeloid Cells;Myeloid Progenitor Cells;Myeloproliferative disease;Neutropenia;neutrophil;novel therapeutic intervention;novel therapeutics;Nuclear;nutrient deprivation;overexpression;Oxidative Phosphorylation;Pathogenesis;Patients;Peptide Hydrolases;pharmacologic;Physicians;premature;prevent;Production;Productivity;Progranulocytes;Proteins;Publishing;Rare Diseases;Research;Research Personnel;Resources;response;Running;Scientist;Secondary to;Severe congenital neutropenia;skills;Source;stem cell biology;Stress;System;Testing;Training;Universities;Vocational Guidance;Washington

PROJECT_TITLE: Mechanisms of Impaired Granulopoiesis Due to CLPB Mutations


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Headaches;Health Services;Mental Health;Neurosciences;Pain Research;Pediatric;Physical Injury - Accidents and Adverse Effects;Primary Health Care;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury;Unintentional Childhood Injury

ORG_CITY: SEATTLE

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

ORG_STATE: WA

PHR: PROJECT NARRATIVE More than one million US youth sustain a concussion each year and one in three have symptoms like headache and trouble concentrating lasting longer than a month, described as persistent post-concussive symptoms or PPCS. We developed a collaborative care (CC) treatment approach for youth with concussion, finding benefit from wraparound care including cognitive-behavioral therapy, parenting skills training and care management (including advising families regarding medications). We are now proposing to optimize the CC approach, streamlining it to only include components that are effective, in order to maximize accessibility of this approach as we work towards larger scale implementation and dissemination.

PI_NAMEs: CHRISMAN, SARA P.D.;MC CARTY, CAROLYN A (contact)

PROGRAM_OFFICER_NAME: NURMINSKAYA, MARIA

PROJECT_TERMS: Address;Adolescent;Adolescent Development;Affect;aged;Ambulatory Care Facilities;Brain Concussion;care delivery;Caring;Child;child depression;Child Rearing;Clinical;Cognitive Therapy;collaborative care;Combined Modality Therapy;comorbidity;Computer software;concussive symptom;design;Dissemination and Implementation;Distal;Distress;Educational Status;Effectiveness;Effectiveness of Interventions;effectiveness/implementation trial;Emotional;emotional distress;Ethnic Origin;evidence base;Evidence based intervention;Evidence based treatment;experience;Failure;Family;Fatigue;Functional disorder;Funding;Future;Geographic Locations;group intervention;Headache;Health Care Costs;health related quality of life;improved;Individual;Intervention;intervention effect;intervention refinement;Link;Managed Care;Measures;Mediation;Mediator;Medical;Mental Health;Mental Health Services;Modeling;Moods;multiphase optimization strategy;Outcome;Pain;parenting intervention;Parents;Participant;Persons;Pharmaceutical Preparations;Post-Concussion Syndrome;primary outcome;Psychologist;Quality of life;Race;Randomized;Randomized, Controlled Trials;recruit;Research;response;Sample Size;Sampling;Schools;secondary outcome;Self Efficacy;Services;sex;skills;Sleep;Sleep disturbances;social;standard of care;Structure;Surveys;Symptoms;targeted treatment;Testing;treatment as usual;treatment effect;treatment group;Videoconferencing;virtual;Work;Youth

PROJECT_TITLE: Optimizing Collaborative Care for Youth with Persistent Post-Concussive Symptoms

STUDY_SECTION: CMGC

STUDY_SECTION_NAME: Clinical Management in General Care Settings Study Section[CMGC]


ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative Inhibitory synapses are crucial for controlling neuron and circuit excitability, neuronal firing and synaptic plasticity. Inhibitory synaptic function is altered in numerous neuropsychiatric and neurodevelopmental brain disorders. A better understanding of the molecular mechanisms that drive inhibitory synaptic plasticity and function will have the potential to direct novel therapeutic strategies for management of these conditions.

PI_NAMEs: SMITH, KATHARINE RACHEL (contact)

PROGRAM_OFFICER_NAME: DRISCOLL, JAMIE DANIELLE

PROJECT_TERMS: Behavior;Brain;Brain Diseases;Chemosensitization;Cognition;Data;Dendrites;Disease;Electrophysiology (science);Equilibrium;experience;experimental study;gene repression;Genetic Transcription;gephyrin;Glutamates;Health;Hippocampus;Image;In Vitro;in vivo;Inhibitory Synapse;insight;Learning;Long-Term Potentiation;Mediating;Memory;Messenger RNA;Methods;MicroRNAs;Molecular;N-Methyl-D-Aspartate Receptors;neural;neuronal circuitry;Neurons;neuropsychiatry;neurotransmission;novel;novel therapeutic intervention;nuclear factors of activated T-cells;Pathology;Pathway interactions;Phase;Play;postsynaptic;Process;protein expression;Proteins;receptor;Regulation;Role;Scaffolding Protein;Sensory;Signal Repression;Signal Transduction;Site;Slice;Structure;Synapses;synaptic function;synaptic inhibition;Synaptic plasticity;Testing;trafficking;Translating;Translational Regulation;Translations;Up-Regulation;Work

PROJECT_TITLE: Local translation mechanisms to control inhibitory synaptic plasticity

STUDY_SECTION: NC

STUDY_SECTION_NAME: Neuronal Communications Study Section[NC]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Clinical Research;Neurosciences

ORG_DEPT: BIOMEDICAL ENGINEERING

PHR: PROJECT NARRATIVE While it is well established that low frequency cortical activity tracks the dynamics of natural speech, the precise mechanisms that produce this tracking are unknown, greatly limiting our interpretation of experiments on this essential human ability, including in clinical populations. Two specific theories have been advanced to explain this tracking: one that proposes that intrinsic cortical oscillations entrain to the rhythms of speech in an anticipatory manner, and a second that assumes that neural measures of speech processing reflect transient evoked responses in cortex. This project aims to use computational modeling of scalp and intracranial EEG to test the hypothesis that both mechanisms play a role, but that their relative contributions differ depending on the characteristics of the stimuli and the nature of the task.

PI_NAMEs: LALOR, EDMUND  (contact)

PROGRAM_OFFICER_NAME: POREMBA, AMY

PROJECT_TITLE: Characterizing the generative mechanisms underlying the cortical tracking of natural speech

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Genetics;Human Genome;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_DEPT: GENETICS

PHR: NARRATIVE Skull growth is a complex process dependent on differentiation of mesenchyme-derived cells to osteoblasts within the sutures that lie between the developing bones. We will use various RNA sequencing strategies and mouse models to establish in vivo the organization of cell types during normal and abnormal development of the coronal suture, and determine the roles of suture mesenchyme and of the hedgehog signaling pathway within this mesenchyme. This will increase our understanding of normal craniofacial development and disease.

PI_NAMEs: HOLMES, GREG PETER (contact);JABS, ETHYLIN WANG;VAN BAKEL, HARM

PROGRAM_OFFICER_NAME: SAIFUDEEN, ZUBAIDA

PROJECT_TERMS: Ablation;Affect;Age;Apert syndrome;Biological Assay;bone;bone repair;Calvaria;cell type;Cells;Chotzen Syndrome;Complex;coronal suture;craniofacial development;Craniosynostosis;cranium;Defect;Development;Disease;early embryonic stage;Embryo;Embryonic Development;Erinaceidae;experimental study;FGFR2 gene;Frontal bone structure;Gene Expression;Gene Expression Profile;Genes;genetic manipulation;Genetic Transcription;Goals;Growth;Health;Histologic;Human;Human Pathology;Impairment;In Vitro;in vivo;inhibitor;insight;Joints;Knock-out;Label;Ligands;Location;Maintenance;Maps;Mesenchyme;Mesoderm;migration;Modeling;Molecular;mouse model;Mus;mutant;mutant mouse model;Mutate;Mutation;Neural Crest;Neurologic;novel;Operative Surgical Procedures;Osteoblasts;Osteogenesis;osteogenic;osteoprogenitor cell;Parietal bone structure;Pathogenesis;Pathway interactions;Perinatal;Phenotype;Population;Population Study;postnatal;premature;preservation;prevent;Process;programs;Proliferating;receptor;Role;single-cell RNA sequencing;Site;skeletal stem cell;smoothened signaling pathway;Source;spatial integration;spatiotemporal;stem cell niche;stem cell population;stem cells;Surgical sutures;suture fusion;Tamoxifen;Techniques;Time;Tissues;transcriptome sequencing;transcriptomics;TWIST1 gene;Wild Type Mouse

PROJECT_TITLE: Coronal Suture Development in Health and Disease

STUDY_SECTION: SBDD

STUDY_SECTION_NAME: Skeletal Biology Development and Disease Study Section[SBDD]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Crohn's Disease;Digestive Diseases;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Inflammatory Bowel Disease;Racial and Ethnic Minority Health Research;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_DEPT: PATHOLOGY

PHR: PROJECT NARRATIVE The Icahn School of Medicine at Mount Sinai has a long and storied tradition of service to patients with inflammatory bowel disease. The proposed Genetics Research Center will leverage institutional strengths in genetics, immunology, and new technologies. Full institutional and investigator commitment to reducing health disparities via genetics and genomics research is affirmed.

PI_NAMEs: CHO, JUDY H. (contact)

PROGRAM_OFFICER_NAME: SHEA-DONOHUE, TEREZ

PROJECT_TERMS: Acute;Affect;African American;African American population;Alleles;Anal Fistula;Anus;ATAC-seq;Automobile Driving;Biological Assay;Blood;Blood Cells;Blood Platelets;case control;Cell Differentiation process;Cell Maintenance;cell type;Cells;Chronic;Clinical;cohort;Collagen;comparative;Complement;cost effective;Crohn's disease;Data;data integration;Data Set;Development;Dinoprostone;Disease;Disease remission;Distal;early onset;Endoscopy;Epithelial Cells;epithelial stem cell;Epithelium;European;European ancestry;Excision;Fibroblasts;Fistula;Flare;Funding;Gene Frequency;Genes;Genetic;Genetic Diseases;Genetic Research;genetic variant;genome wide association study;Genomics;Genotype;Goals;High Prevalence;Hispanic;Hospitalization;IL6ST gene;Immunologic Surveillance;Immunology;imprint;improved;In Vitro;Inflammation;Inflammatory Bowel Diseases;insight;Institution;interest;intestinal epithelium;Leukocytes;loss of function mutation;Macrophage;Medical;medical schools;Mesenchymal;Modeling;Molecular;monocyte;Morbidity - disease rate;Multiomic Data;multiple omics;Mutation;Myelogenous;Myeloid Cells;National Institute of Diabetes and Digestive and Kidney Diseases;new technology;New York;novel strategies;Outcome;Pathway interactions;Patients;Platelet-Derived Growth Factor alpha Receptor;Play;polygenic risk score;Population;Reactive Oxygen Species;Recording of previous events;recruit;rectal mucosa;Rectum;Reduce health disparities;Reporting;Research;Research Personnel;Resolution;response;risk variant;Role;Sampling;Services;single cell analysis;stem;stem cells;Stromal Cells;System;Systemic disease;Technology;therapy resistant;Thrombosis;Time;Tissues;TNF gene;TNFSF15 gene;Transcription Factor AP-1;transcriptome;transcriptome sequencing;transcriptomics;Ulcerative Colitis;WNT2 gene;Work;XCL1 gene

PROJECT_TITLE: Mount Sinai NYC Genetics Research Center: Multi-omic integration across data-types, cell niches and populations


ADMINISTERING_IC: AA

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Biotechnology;Diabetes;Genetics;HIV/AIDS;Infectious Diseases;Substance Misuse

ORG_CITY: NEW ORLEANS

ORG_DEPT: PHYSIOLOGY

ORG_NAME: LSU HEALTH SCIENCES CENTER

ORG_STATE: LA

PHR: Narrative This NRSA F30 fellowship will provide an invaluable training opportunity for a future physician scientist as she develops into an emerging leader in the field of alcohol research and endocrinology. The proposed studies will investigate the role of extracellular vesicles on alcohol-mediated decreases in skeletal muscle insulin sensitivity using a highly relevant preclinical model of HIV. The findings from these studies will provide mechanistic insight for future translational studies and therapeutic applications aiming to alleviate alcohol-induced skeletal muscle insulin insensitivity.

PI_NAMEs: BOURGEOIS, BRIANNA LEILANI (contact)

PROGRAM_OFFICER_NAME: LIN, LI

PROJECT_TERMS: Adhalin;Affect;Alcohol consumption;alcohol research;alcohol risk;Alcoholic Hepatitis;Alcohols;antiretroviral therapy;Binding;career;career development;Cells;Chronic;comorbidity;Data;Diabetes Mellitus;differential expression;Electroporation;Endocrine;Endocrinology;Ensure;experimental study;extracellular vesicles;Fellowship;Fostering;Functional disorder;Funding;Future;Gene Expression;General Population;Glucose;glucose uptake;GLUT 4 protein;Health Sciences;Hepatocyte;HIV;HIV/AIDS;Impairment;improved;In Vitro;in vivo;insight;Insulin;Insulin Resistance;insulin sensitivity;insulin signaling;Insulin Signaling Pathway;intercellular communication;interest;Laboratories;Life Expectancy;Lipid Bilayers;Lipids;Literature;Liver diseases;Louisiana;Macaca;Macaca mulatta;Measures;Mediating;Medical;Medical Research;Medicine;Mentors;Metabolic;MicroRNAs;miRNA expression profiling;Modeling;monocyte;Mus;Muscle;Muscle Fibers;Myoblasts;nanoparticle;National Institute on Alcohol Abuse and Alcoholism;National Research Service Awards;nerve stem cell;novel;paracrine;Pathologic;Pathway interactions;Persons;Phosphorylation;Physicians;Physiological;Plasma;Pre-Clinical Model;pre-clinical research;preclinical study;Prevalence;Proteins;Publishing;Regulation;Research;research study;RNA;Role;Scientist;Signal Transduction;Site;SIV;Skeletal Muscle;skeletal muscle differentiation;skeletal muscle metabolism;Skeletal Myoblasts;Structure of beta Cell of islet;Techniques;Testing;Therapeutic;Training;training opportunity;translational potential;translational study;translational therapeutics;Universities;Untranslated RNA;vesicular release;Virus Diseases;Western Blotting;Work

PROJECT_TITLE: Alcohol-induced Skeletal Muscle Insulin Insensitivity in SIV/HIV: Myotube-derived Extracellular Vesicle-mediated Mechanisms


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Orphan Drug;Prostate Cancer;Rare Diseases;Urologic Diseases

ORG_CITY: AUBURN

ORG_NAME: SYNTRIX BIOSYSTEMS, INC.

PHR: Prostate cancer (PC) is the second leading cause of cancer-related death among American men, and the vast majority of these deaths are due to metastatic, castration-resistant PC (mCRPC). SX-682 is a clinical-stage, small-molecule CXCR1/2 inhibitor validated in numerous published pre-clinical cancer models including mCRPC, and which exhibits activity in patients with melanoma, pancreatic adenocarcinoma and myelodysplastic syndromes. This project will advance SX-682 through the first ever mCRPC clinical trial of a CXCR1/2 inhibitor with enzalutamide in patients failing abiraterone, and if successful, SX-682 would be a highly valuable new addition to the existing mCRPC treatment landscape.

PI_NAMEs: SCHULER, AARON D (contact);ZEBALA, JOHN A

PROGRAM_OFFICER_NAME: EVANS, GREGORY

PROJECT_TERMS: abiraterone;Acceleration;Agonist;American;androgen deprivation therapy;androgen independent prostate cancer;Androgen Receptor;Androgen Suppression;Androgens;antagonist;arm;Binding;Binomial Distribution;Biochemical;Biopsy;Blood;burden of illness;cancer cell;cancer clinical trial;cancer diagnosis;Cancer Etiology;Cancer Model;Cancer Patient;CD8-Positive T-Lymphocytes;Cessation of life;chemokine receptor;Clinical;clinical efficacy;clinical research site;cohort;CXCL6 gene;Cyclic GMP;CYP17A1 gene;Data;design;docetaxel;Dose;Drug Kinetics;Dysmyelopoietic Syndromes;efficacy testing;efficacy trial;Enrollment;enzalutamide;Evaluable Disease;Exhibits;Genetic Engineering;hazard;Histology;Human;IL8 gene;IL8RA gene;IL8RB gene;inhibitor;Ligands;Macrophage;Malignant neoplasm of prostate;manufacture;Measurable Disease;Measurement;Mediating;Melanoma;men;Mus;Neoplasm Metastasis;neuroendocrine cancer;Oncology;open label;Pancreatic Adenocarcinoma;participant enrollment;Patients;Phagocytosis;Pharmaceutical Preparations;Phase;Population;pre-clinical;Prednisone;primary endpoint;prognostic;prostate cancer model;Prostate Cancer therapy;Protein Isoforms;Publishing;Radical Prostatectomy;randomized trial;Recurrence;Refractory;Regulatory T-Lymphocyte;research clinical testing;Resistance;Resistance development;Serum;Small Business Innovation Research Grant;small molecule;Stable Disease;standard of care;Subgroup;Surface;Testing;Testosterone;Therapeutic;therapeutic target;Time;trial design;tumor;Xenograft procedure

PROJECT_TITLE: A Phase 2, Single-Arm Study of the CXCR1/2 Inhibitor SX-682 Plus Enzalutamide in Men with Abiraterone-Resistant Metastatic Castration Resistant Prostate Cancer (mCRPC)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CTH-T(10)B]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Dental, Oral, and Craniofacial Disease;Diabetes;Digestive Diseases;Genetics;Human Genome;Infectious Diseases;Microbiome;Nutrition;Pancreatic Cancer;Prevention;Rare Diseases

ORG_DEPT: SURGERY

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: People with chronic pancreatitis and diabetes are at increased risk for getting pancreas cancer but the causes are not known. Bacteria are normally present in our mouth and gut, and recently scientists have found that changes in these bacteria can lead to cancer. We will study whether chronic pancreatitis and diabetes cause changes in bacteria in the pancreas, the mouth, and in the stool that could lead to pancreatic cancer; these investigations may lead to better ways to diagnose and treat this deadly disease.

PI_NAMEs: FISHER, WILLIAM E (contact)

PROJECT_TERMS: Affect;Bacteria;biobank;Biodiversity;biomarker discovery;Cancer Etiology;chemotherapeutic agent;chronic pancreatitis;Clinical;Clinical Data;Clinical Trials;Cohort Studies;Collaborations;college;commensal bacteria;Conduct Clinical Trials;cost;Data;Data Collection;design;Development;Diabetes Mellitus;Diagnosis;Diagnostic Procedure;Disease;Disease Marker;Disease Progression;Disease susceptibility;DNA;dysbiosis;early detection biomarkers;Early Diagnosis;Early identification;Early treatment;Enrollment;Etiology;experience;experimental study;Feces;Firmicutes;Functional disorder;Genome;Goals;Growth;gut dysbiosis;host microbiome;Human Genome;human genome sequencing;Human Microbiome;Immune response;Immunologic Receptors;Immunotherapy;Inflammation;Inflammatory;innovation;insight;Intervention;Investigation;Leadership;Malignant neoplasm of pancreas;Malignant Neoplasms;Medicine;member;Metabolism;Metagenomics;Methods;microbial;microbial signature;microbiome;microbiome research;microbiota;microorganism;Modeling;National Institute of Diabetes and Digestive and Kidney Diseases;Nature;next generation sequencing;novel strategies;nutrition;Obesity;Oral;Oral cavity;oral microbiome;oral pathogen;Organism;Pancreas;pancreas development;Pancreatic Ductal Adenocarcinoma;pancreatic neoplasm;pancreatic tumorigenesis;Pancreatitis;Pathogenesis;Pathogenicity;patient population;Patients;Pattern;Periodontitis;Persons;Porphyromonas gingivalis;Prevention;Prevention strategy;Process;Prognostic Marker;prognostic method;prospective;Proteobacteria;Protocols documentation;recruit;repository;Research;Resistance;Risk;Risk Factors;Role;Saliva;Sampling;Scientist;Site;Smoking;Streptococcus mitis;Survival Rate;systemic inflammatory response;Taxonomy;Testing;Therapeutic;Tissue Banks;Tissue Sample;Tissues;treatment strategy;tumor;Tumor Tissue;tumor-immune system interactions;United States National Institutes of Health;Variant

PROJECT_TITLE: DYSBIOTIC MICROBIOME IN PANCREATITIS, DIABETES, AND PANCREATIC CANCER


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Assistive Technology;Behavioral and Social Science;Bioengineering;Disability Research;Physical Rehabilitation;Rehabilitation;Social Determinants of Health

ORG_CITY: KENNESAW

ORG_NAME: KENNESAW STATE UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative This educational program addresses a lack of diversity issue in the engineering and science workforce, by providing undergraduates with diverse backgrounds a positive research experience that empowers and encourages them to pursue PhD degrees for careers in academia and industry. Concurrent with the program enhancing diversity, another national need can be fulfilled to train a research scientist workforce that can accelerate the biomedical advancements in assistive technology, orthotics, prosthetics, and rehabilitation. Persons with disability who use assistive technology will benefit from the new biomedical research developments through greater independence, mobility, and improved treatment outcomes.

PI_NAMEs: KOGLER, GEZA FRANK (contact)

PROJECT_TERMS: Academia;Acceleration;Address;Administrator;Admission activity;Advisory Committees;aging population;Basic Science;Biomedical Engineering;Biomedical Research;bridge program;career;career development;Clinic;Clinical;cohort;Competence;Dedications;disability;Disabled Persons;Disadvantaged;disadvantaged student;Diverse Workforce;Doctor of Philosophy;Doctor's Degree;economic disparity;Education;education research;Elements;Eligibility Determination;empowerment;Engineering;Ensure;Environment;experience;Faculty;faculty mentor;faculty research;Fostering;Foundations;Future;General Population;Goals;graduate school;Health;Healthcare;high school;High School Student;improved;improved outcome;Industrialization;Industry;innovation;innovative technologies;Institution;Institutional Review Boards;Instruction;Interdisciplinary Study;interest;Knowledge;laboratory experience;Leadership;Learning;Life;life span;Light;low socioeconomic status;Manuscripts;Measures;Mentors;Mentorship;Minority;Mission;new technology;next generation;Oral;Orthotic Devices;Paper;Participant;participant retention;patient oriented;Performance;Population;posters;Privatization;Problem Solving;programs;Prosthesis;Publications;recruit;Rehabilitation therapy;Research;research and development;research faculty;Research Personnel;Research Project Grants;Research Proposals;research study;Research Training;Rotation;Science;Science, Technology, Engineering and Mathematics Education;Scientist;Self-Help Devices;skills;social disparities;Societies;State Government;Statistical Data Interpretation;STEM field;STEM student;student participation;student training;Students;success;summer research;Technology;text searching;tool;Training;Training Programs;Treatment outcome;undergraduate research experience;undergraduate student;Underrepresented Minority;Underrepresented Populations;United States;United States National Institutes of Health;Universities;Vocational Guidance;Woman;Work

PROJECT_TITLE: Bioengineering Research and Interdisciplinary Training – ESTEEMED (BRITE)


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative: The goal of this proposal is to understand the coupling between cell biological and physical mechanisms that drive cell shape changes, control cell behaviors, generate forces, and establish passive tissue properties such as stiffness, active force production by convergence and extension, and how passive mechanics and active forces shape a vertebrate embryo. The significance of our work extends beyond defining the mechanical conditions and their role in early development to provide fundamental physical principles for future functional tissue engineers, allow a more complete understanding of the contribution of cell- and tissue-mechanics during tissue self-assembly, and to understand the role of tissue mechanics in oncogenesis.

PI_NAMEs: DAVIDSON, LANCE A. (contact)

PROGRAM_OFFICER_NAME: MUKHOPADHYAY, MAHUA

PROJECT_TERMS: Actins;Actomyosin;Affect;Anatomy;animal model development;Biological;Biomechanics;Biomedical Engineering;biophysical techniques;Biophysics;cell behavior;cell cortex;Cell Shape;Cells;Cellular biology;Complement;convergent extension;Coupling;Cues;Cytoskeleton;Data;Defect;density;Development;Developmental Biology;disease model;Dorsal;Drosophila genus;Ectoderm Cell;Elasticity;Embryo;Endoderm Cell;Epithelium;Event;Exposure to;Failure;Fibrosis;Future;gastrulation;Generations;genetic analysis;Germ Layers;Goals;human disease;Image;insight;knock-down;Malignant Neoplasms;Measures;mechanical behavior;mechanical force;mechanical properties;Mechanics;Memory;Mesoderm Cell;Microsurgery;Molecular;Molecular Biology Techniques;Morphogenesis;Movement;multidisciplinary;Myosin ATPase;Organ;Organogenesis;Pathway interactions;Phenotype;polarized cell;polymerization;Polymers;Process;Production;progenitor;Property;protein complex;Proteins;Rana;Regulation;Research Personnel;Role;self assembly;Shapes;Signal Pathway;simulation;Structure;success;Techniques;Testing;Tissue Engineering;Tissues;tool;transmission process;tumorigenesis;Undifferentiated;vertebrate embryos;Work

PROJECT_TITLE: Biomechanics of Morphogenesis

STUDY_SECTION_NAME: Development - 2 Study Section[DEV2]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Microbiome;Sexually Transmitted Infections;Urologic Diseases

ORG_CITY: WEST LAFAYETTE

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: PROJECT NARRATIVE Rampant resistance to frontline antibiotics has caused the CDC and the WHO each to classify N. gonorrhoeae as a superbug and a future with an untreatable gonococcal infection is a real possibility. This proposal seeks to continue drug development of a highly promising small molecule scaffold with anti-gonococcal activity that was discovered as part of a drug-repurposing screen. The project includes small molecule medicinal chemistry lead optimization, intracellular target validation, structural biology, in vitro anti-microbial assays, and in vivo safety, PK and anti-gonorrhea efficacy assays.

PI_NAMEs: FLAHERTY, DANIEL PATRICK (contact)

PROGRAM_OFFICER_NAME: CONNOLLY, KRISTIE LEE

PROJECT_TERMS: Acetazolamide;Address;Adverse effects;analog;anti-microbial drug;Antibiotic Therapy;Antibiotics;antimicrobial;Antimicrobial Effect;Anus;Arthritis;Azithromycin;Bacteria;Biochemical;Biological Assay;Biological Availability;Birth;Blindness;carbonate dehydratase;Carbonic Anhydrase Inhibitors;Case Study;Cells;Centers for Disease Control and Prevention (U.S.);Cephalosporins;Chronic;Classification;Clinical;clinical application;combat;commensal bacteria;Computer Models;Data;design;Development;Dose;drug candidate;drug development;Drug Kinetics;drug repurposing;Drug-resistant Neisseria Gonorrhoeae;dysbiosis;Ectopic Pregnancy;Endocarditis;Enzymes;Evaluation;Excretory function;Exhibits;FDA approved;Future;Generations;Genitourinary system;Goals;Gonorrhea;gut microbiota;Healthcare Systems;Human;improved;In Vitro;in vivo;in vivo evaluation;Infection;Infectious Skin Diseases;Infertility;inhibitor;innovation;International;Investigational Drugs;Knowledge;Lead;lead optimization;Left;Ligand Binding;Literature;Modeling;Modification;mouse model;Mus;Nasopharynx;Neisseria gonorrhoeae;new therapeutic target;next generation;novel;novel strategies;Oral;Orthologous Gene;pathogen;pathogenic bacteria;Pathogenicity;Pelvic Inflammatory Disease;Permeability;Pharmaceutical Chemistry;pharmacologic;Property;Protein Isoforms;Public Health;Regimen;Reporting;Resistance;resistance mechanism;resistant strain;Safety;scaffold;Sexually Transmitted Diseases;small molecule;Societies;structural biology;Structure;Superbug;Surveillance Program;Testing;Therapeutic;Therapeutic Agents;therapeutic target;Tissues;Urine;urogenital tract;vaginal microbiota;Validation;Vertical Disease Transmission;World Health;World Health Organization

PROJECT_TITLE: Development of novel anti-Neisseria gonorrhoeae therapeutic agents

STUDY_SECTION: DDR

STUDY_SECTION_NAME: Drug Discovery and Mechanisms of Antimicrobial Resistance Study Section[DDR]


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Digestive Diseases;Pancreatic Cancer;Prevention;Rare Diseases

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

PHR: This is an application to renew the “Greater Los Angeles Clinical Center of the Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer,” which consists of an expert team well-qualified to carry out studies of the Consortium in Los Angeles County, the most populous and ethnically diverse county in the United States. We plan to adjust and expand our recruitment strategies for cohort studies of the Consortium to help meet national goals; we will also continue progress on a series of ancillary studies within the Consortium designed to detect and treat pancreatic diseases. In addition, we propose new studies to develop prediction models for diabetes in chronic pancreatitis, interrogate the role of digestive enzyme insufficiency in this form of diabetes, and develop novel imaging-based methods for early pancreatic cancer detection that will, in turn, decrease the morbidity of pancreatic cancer.

PI_NAMEs: GOODARZI, MARK ;PANDOL, STEPHEN J. (contact)

PROGRAM_OFFICER_NAME: UNALP-ARIDA, AYNUR

PROJECT_TERMS: acute pancreatitis;Adult;Ancillary Study;Area;Artificial Intelligence;Biological Assay;blood glucose regulation;California;Cancer Detection;Child;Childhood;chronic pancreatitis;Chronic Phase;Clinical;clinical center;Clinical Management;Clinical Research;Clinical Treatment;Clinical Trials;Clinical Trials Data Monitoring Committees;Cohort Studies;Collaborations;Complex;County;design;Development;Diabetes Mellitus;Diagnosis;Diagnostic;Disease;Early Diagnosis;Enzymes;epidemiology study;ethnic diversity;Exocrine pancreas;Exocrine pancreatic insufficiency;Functional disorder;Future;Genetic Predisposition to Disease;Goals;Health system;Healthcare Systems;Human;imaging modality;Leadership;liquid biopsy;Los Angeles;Malignant neoplasm of pancreas;Medical center;Methods;model building;Modeling;Morbidity - disease rate;Names;National Cancer Institute;National Institute of Diabetes and Digestive and Kidney Diseases;Natural History;Non-Insulin-Dependent Diabetes Mellitus;novel;novel diagnostics;organizational structure;Pancreatic Diseases;Pancreatic Ductal Adenocarcinoma;Pancreatic enzyme;Pancreatitis;participant retention;Pathogenicity;Patients;Pharmacologic Substance;predictive modeling;premalignant;Principal Investigator;Public Health;Qualifying;recruit;Recurrence;Research;Research Personnel;Resources;response;Risk Factors;Role;Series;Site;study population;Techniques;treatment trial;United States;United States National Institutes of Health;Universities;working group;X-Ray Computed Tomography

PROJECT_TITLE: Greater Los Angeles Clinical Center of the Consortium for the Study of Chronic Pancreatitis, Diabetes and Pancreatic Cancer


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Data Science;Digestive Diseases;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Rare Diseases;Vector-Borne Diseases

ORG_NAME: PARASITE ID, CORP.

PHR: PROJECT NARRATIVE Accurate surveillance testing in the field and timely and accurate reporting of results are required for effective decision-making by soil-transmitted helminth (STH) infection and schistosomiasis control and prevention programs. This project will develop and test a mobile phone-based STH-schistosomiasis diagnostic system that employs machine learning to very accurately identify and count parasite eggs from microscopy images of stool samples. This mobile app will work in the absence of any internet connection and will streamline collection of surveillance data for integration into a cloud-based surveillance platform that increases data visibility.

PI_NAMEs: HENDERSON, KIERSTEN  (contact)

PROGRAM_OFFICER_NAME: NEWSOME, BRAD

PROJECT_TERMS: Affect;algorithm training;Algorithms;Architecture;Cellular Phone;Classification;cloud based;cloud platform;cloud storage;Collection;convolutional neural network;cost;Cost Savings;dashboard;Data;data access;Data Aggregation;Data Collection;data integration;Data Scientist;data visualization;Databases;Decision Making;deep learning;deep learning model;design;diagnostic platform;digital data;disorder control;egg;Feedback;Future;Geographic Locations;global health;Goals;Health;helminth infection;Helminths;Image;improved;Infection Control;Internet;Intervention;Location;Machine Learning;machine learning algorithm;Microscope;Microscopic;microscopic imaging;Microscopy;mobile application;Pain;Parasites;Parasitic infection;Persons;Phase;prevent;Prevention;Prevention program;Process;product development;Publishing;Reporting;Research Personnel;Schistosoma;Schistosomiasis;Soil;Speed;Standardization;stool sample;Surface;surveillance data;System;Testing;Time;tool;transmission process;usability;Validation;validation studies;Visualization;web app;Work

PROJECT_TITLE: A Machine Learning-Based Mobile Application and Cloud Platform to Enable Accurate and Streamlined Surveillance of Soil-Transmitted Helminth Infection and Schistosomiasis


NIH_SPENDING_CATS: Aging;Biotechnology;Genetics;Pain Research;Physical Injury - Accidents and Adverse Effects

ORG_CITY: New Rochelle

ORG_NAME: NEW YORK/R&D/CTR/TRANSLATIONAL MED/THER

PHR: Project Narrative  Tendinopathy is a common chronic tendon disorder, characterized by pain and impaired performance, and currently has no cure or effective treatments. Our preliminary studies suggest that a specific microRNA has therapeutic potential in healing diseased tendon tissue in rats. The proposed study will test the efficacy and safety of this microRNA in rodent and rabbit models of tendinopathy.

PI_NAMEs: FUNG, DAVID T (contact);SUN, LI

PROGRAM_OFFICER_NAME: FOX, JENNIFER THERESA

PROJECT_TERMS: achilles tendon;Adverse effects;Affect;Age Years;Aging;aging population;Animal Model;Apoptosis;Attention;Binding;Bioinformatics;biological adaptation to stress;Biological Assay;Businesses;Chemicals;Chronic;chronic inflammatory disease;Cicatrix;Clinical;Clinical Pathology;Clinical Trials;collagenase;commercial application;commercialization;Data;Databases;Deterioration;Disease;Dose;Drug Kinetics;effective therapy;efficacy evaluation;efficacy testing;Equity;Exhibits;exosome;FDA approved;Formulation;Future;Gene Expression;Genes;healing;Histologic;Human;Hyaluronic Acid;Impairment;improved;Individual;Inflammation;Inflammation Mediators;Injections;Investments;loss of function;mechanical properties;Mediating;Mediator;Mesenchymal Stem Cells;Microarray Analysis;microRNA delivery;MicroRNAs;Modeling;Modification;New York;Non-Steroidal Anti-Inflammatory Agents;novel;novel therapeutic intervention;novel therapeutics;nuclease;Operative Surgical Procedures;Oryctolagus cuniculus;Outcome;Pain;pain behavior;Pathogenesis;Pathology;Pathway interactions;Performance;Pharmaceutical Preparations;Phase;phase 2 study;PKH 26;Placebos;pleiotropism;Predisposing Factor;Predisposition;Rattus;repaired;research and development;response;Ribonucleotides;RNA;Rodent;Rodent Model;Rupture;Safety;scaffold;Schedule;Site;Steroids;Swelling;Technology;Tendinopathy;tendon rupture;Tendon structure;Testing;Therapeutic;Therapeutic Effect;Tissues;Toxic effect;translational medicine;translational therapeutics;trend;two-dimensional;uptake

PROJECT_TITLE: miRNA drug for tendinopathy


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biodefense and Related Countermeasures;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Dementia;Emerging Infectious Diseases;Hematology;Infectious Diseases;Neurodegenerative;Neurosciences;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: Project Narrative Cerebral small vessel disease (CSVD) affects small penetrating arteries, arterioles, capillaries and venules, causing small subcortical infarcts, lacunae, white matter hyperintensity, enlarged perivascular spaces, cerebral microbleeds and brain atrophy. CSVD pathology is a leading cause of cognitive impairment and dementia. The goal of this project is to assess impact of SARS-CoV-2 infection on CSVD in older individuals. The results of the study will provide essential data that can be used in the future to design appropriate clinical intervention to slow down the progression of CSVD in older individuals previously infected with SARS-CoV-2.

PI_NAMEs: SCHIFITTO, GIOVANNI  (contact)

PROGRAM_OFFICER_NAME: MARIC, MAJA

PROJECT_TERMS: 2019-nCoV;Acceleration;Address;Affect;Age;age related neurodegeneration;aged;aging related;Alzheimer's Disease;Arginine;Arteries;arteriole;Autopsy;Blood - brain barrier anatomy;Blood capillaries;Blood Coagulation Disorders;Blood Vessels;Brain;Brain hemorrhage;brain parenchyma;central nervous system injury;cerebral atrophy;cerebral microbleeds;Cerebral small vessel disease;cerebrovascular;Cerebrovascular Circulation;cerebrovascular reactivity;Cerebrum;Chronic;Clinical;Cognition;Cognitive;cognitive function;cognitive performance;cohort;comparison control;Complement 3b;COVID-19;COVID-19 neurocognitive sequelae;COVID-19 patient;Critical Care;cytokine;Data;Dementia;density;Deposition;design;Diagnosis;Endothelial Cells;endothelial dysfunction;Endothelium;exosome;Fingers;Future;Glial Fibrillary Acidic Protein;Goals;gray matter;Hemorrhage;Hospitalization;Image;imaging detection;Impaired cognition;indexing;Individual;Infection;Injury;interest;Intervention;Iron;leukocyte activation;Light;Link;Long-Term Effects;Macrophage;Magnetic Resonance;Magnetic Resonance Imaging;Maps;Measurable;Measures;Microcirculation;Microglia;monocyte;Multimodal Imaging;Neurites;Neurocognitive;Neurodegenerative Disorders;neurofilament;Neurologic;neurovascular unit;older adult;Older Population;Pathogenesis;Pathology;Penetration;Peripheral;Phase;Plasma;Platelet Activation;Population;Predisposition;Process;reactive hyperemia;Recording of previous events;Recovery;Reporting;SARS-CoV-2 infection;Secondary to;Severities;sex;Structure;Subcortical Infarctions;Symptoms;Techniques;Tissues;Vascular Dementia;venule;white matter;White Matter Hyperintensity;Width

PROJECT_TITLE: Brain signature of SARS-CoV-2 Infection and its impact on long-term cognitive functioning in older adults

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Autoimmune Disease;Brain Disorders;Genetics;Human Genome;Infectious Diseases;Multiple Sclerosis;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: BURLINGTON

ORG_DEPT: OTHER CLINICAL SCIENCES

ORG_NAME: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE

ORG_STATE: VT

PHR: PROJECT NARRATIVE Multiple sclerosis is a polygenic and multifactorial chronic autoimmune disease that is the leading cause of non- traumatic neurological disability in young adults. The genetic and environmental molecular mechanisms underlying many aspects of this disease are not well understood. In this application, we propose to utilize several novel systems genetics approaches in mice to identify pathogenetic and environmental mechanisms underlying progression of this disease.

PI_NAMEs: KREMENTSOV, DIMITRY N (contact)

PROGRAM_OFFICER_NAME: GUERAU, MIREIA

PROJECT_TERMS: Address;Affect;Alleles;Animal Model;Autoimmune Diseases;Autoimmunity;Automobile Driving;Axon;Candidate Disease Gene;candidate identification;CD4 Positive T Lymphocytes;Cell Reprogramming;Cells;Central Nervous System;Chromosome Mapping;Chromosomes;Chronic;chronic autoimmune disease;Chronic Disease;chronic infection;clinical phenotype;CNS autoimmune disease;Complex;consomic;Control Locus;Data;Demyelinations;design;Disease;Disease Progression;disorder control;disorder risk;Dissection;Down-Regulation;Environment;Environmental Risk Factor;Epstein-Barr Virus Infections;Etiology;Exhibits;Experimental Autoimmune Encephalomyelitis;Experimental Designs;Failure;Funding;gene environment interaction;Gene Expression Profile;Genes;Genetic;genetic approach;genetic architecture;Genetic Determinism;Genetic Heterogeneity;Genetic Structures;Genetic Variation;genome wide association study;Genotype;Gliosis;gut microbiota;Heritability;Heterogeneity;high risk;Human;human disease;Human Herpesvirus 4;human model;Immune;Immunization;Immunologics;immunoregulation;In Vitro;Inbred Strains Mice;Incidence;Individual;Infection;Infectious Diseases Research;Knowledge;lead candidate;Machine Learning;Maps;Mediating;men;microbiota composition;model design;Modeling;Molecular;mouse genetics;mouse model;Multiple Sclerosis;Mus;Myelin;Neurologic Dysfunctions;Neurological disability;novel;Orthologous Gene;Outcome;Pathogenesis;Pathology;pharmacologic;Phenotype;Population;Predisposition;Primary Progressive Multiple Sclerosis;Publishing;Quantitative Trait Loci;Refractory;Relapsing-Remitting Multiple Sclerosis;Resources;Risk;Risk Factors;Role;Severities;sex;Sex Differences;System;Tissues;tool;trait;Transgenic Mice;Validation;Viral Load result;virtual;Virus;Virus Diseases;Virus Replication;Vitamin D;Woman;Work;young adult

PROJECT_TITLE: Novel mouse models to dissect the role of genetics, sex, and environment in heterogeneous outcomes in CNS autoimmune disease


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Aging;Brain Disorders;Genetics;Huntington's Disease;Neurodegenerative;Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: PROJECT NARRATIVE Polyglutamine (polyQ) expansion diseases are a family of inherited aging-associated diseases characterized by a failure of the cell’s protein quality control machinery and a subsequent accumulation of misfolded protein aggregates. Recent work has highlighted a potential beneficial role for the novel post-translational modification AMPylation, in regulating the aggregation and toxicity of polyQ disease proteins, but the mechanisms underlying this process remains unknown. This proposal will utilize complementary approaches to (1) uncover how AMPylation deficiency facilitates suppression of polyQ toxicity in C. elegans, and (2) determine how AMPylation levels impact polyQ dynamics in physiologically relevant in vitro models of Huntington’s disease and SCA3.

PI_NAMEs: VAN PELT, KATE MATTHYS (contact)

PROGRAM_OFFICER_NAME: MATTHEWS, MARGUERITE

PROJECT_TERMS: Adenosine Monophosphate;Affect;age related neurodegeneration;aging related disease;Alleles;Animals;arm;Attenuated;Biochemical;biological adaptation to stress;Biological Assay;Buffers;Caenorhabditis elegans;CAG repeat;Cells;Cellular Structures;Chemicals;CRISPR interference;Data;derepression;Development;Disease;disease model;Excision;Failure;Family;follow-up;General Population;Genes;Genetic;Goals;hallmarks of aging;Heat-Shock Proteins 70;Human;human embryonic stem cell;Huntington Disease;Huntington gene;In Vitro;in vitro Model;Inclusion Bodies;Individual;Inherited;knock-down;Knock-out;Knowledge;Length;Link;Machado-Joseph Disease;Maintenance;Mediating;Mediator;misfolded protein;MJD1 protein;Molecular;Molecular Chaperones;Mutagenesis;mutant;Mutation;Neurodegenerative Disorders;neuron loss;Neurons;novel;Nucleotides;Orthologous Gene;overexpression;Pathogenicity;Pathologic;Pathway interactions;Patients;Physiological;polyglutamine;Post-Translational Protein Processing;Post-Translational Regulation;Prevalence;Process;protein aggregation;protein function;protein misfolding;Proteins;proteostasis;Quality Control;Regulation;Reporting;Research;response;RNA Interference;Role;Signal Pathway;Solubility;stem cells;Stress;targeted treatment;Techniques;Testing;Therapeutic;Therapeutic Intervention;Tissues;Toxic effect;Type 1 Spinocerebellar Ataxia;Work

PROJECT_TITLE: Elucidating the impact of FIC-1/FICD-mediated AMPylation on polyglutamine aggregation dynamics and toxicity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-D(21)L]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Data Science;Drug Abuse (NIDA only);Genetics;HIV/AIDS;Human Genome;Networking and Information Technology R&D (NITRD);Neurosciences;Opioids;Substance Misuse

ORG_CITY: BALTIMORE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: PROJECT NARRATIVE The NeMO-SCORCH data center is coordination center to analyze single cell and other molecular data sets generated by Single Cell Opioid Responses in the Context of HIV (SCORCH) and other NIDA-funded HIV and substance use disorder projects.

PI_NAMEs: HUO, BING-XING ;WHITE, OWEN R (contact)

PROGRAM_OFFICER_NAME: SATTERLEE, JOHN S

PROJECT_TERMS: Archives;Atlases;Binding Sites;Brain;brain abnormalities;Brain Diseases;BRAIN initiative;brain research;cell type;Cells;Chromatin;cloud based;Cloud Computing;Communities;Computer software;computerized data processing;Cytosine;Data;Data Analyses;data archive;data centers;Data Collection;Data Coordinating Center;data dissemination;data ecosystem;data framework;data ingestion;Data Management Resources;data portal;data repository;data resource;Data Set;Data Storage and Retrieval;data submission portal;Databases;Deposition;Documentation;Educational workshop;Ensure;Environment;epigenomics;Evaluation;experience;FAIR principles;Familiarity;federated data;Funding;Generations;Genetic Transcription;Genomic Segment;Goals;histone modification;HIV;indexing;Institution;Internet;Link;Location;Logistics;Maryland;member;Metadata;Modeling;Modification;Molecular;Multiomic Data;multiple data types;multiple omics;National Institute of Drug Abuse;Neurologic;Neurosciences;next generation;operation;Opioid;outreach;Pathway Analysis;Pattern;Policies;Practice Management;programs;public repository;Publications;Quality Control;Regulatory Element;Research;Research Personnel;Research Project Grants;Resources;response;risk mitigation;single cell analysis;Substance Use Disorder;System;tool;transcription factor;United States National Institutes of Health;Universities;user-friendly;Visualization;web site;webinar;Work;working group

PROJECT_TITLE: NeMO Archive: SCORCH Support, Coordination and Outreach


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Drug Abuse (NIDA only);Pediatric;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: UNIVERSITY PARK

ORG_DEPT: PSYCHOLOGY

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

PHR: PROJECT NARRATIVE Researchers have unprecedented access to intensive data collected via smart phones and other devices; many of these datasets hold promise to reveal new information about how complex substance use behavior patterns unfold in daily life and which dynamic psychological and social characteristics confer risk for problematic use. Innovative statistical analyses of intensive data can enable prevention scientists and clinicians to design interventions that target dynamic risk factors within individuals, focusing resources on high- risk days when they are most needed. We will evaluate available approaches and compile much-needed best practices for analyzing these data, apply these approaches to diary data to characterize college students’ substance use patterns in daily life, and disseminate these approaches to facilitate broad adoption by substance use researchers nationally.

PI_NAMEs: LANZA, STEPHANIE T (contact)

PROGRAM_OFFICER_NAME: KURAMOTO-CRAWFORD, SATOKO JANET

PROJECT_TERMS: Acceleration;Acute;Adderall;Address;Adoption;advanced analytics;Affect;Age;Alcohol consumption;Alcohols;analytical method;Anxiety;Award;Behavior;Cannabis;Cellular Phone;Characteristics;Chronic;clinically relevant;Code;Collection;Complex;Complex Mixtures;Computer software;cost estimate;Data;Data Analyses;Data Set;Demographic Factors;Development;Devices;diaries;Disease;Disparity;Drug abuse;Educational workshop;Ensure;Environment;Estimation Techniques;Ethnic Origin;Etiology;Exhibits;Financial Hardship;Guide prevention;Heterogeneity;high risk;Individual;innovation;Institution;Intervention;Investigation;Knowledge;learning materials;Life;Manuscripts;Measurement;Methods;Modeling;next generation;novel;Outcome;Pattern;Performance;Persons;Policies;polysubstance use;Prevention;psychologic;psychosocial;Psychosocial Factor;Public Health;Race;repository;Research;Research Personnel;Resources;response;Risk;Risk Factors;Scientist;sex;Sexual and Gender Minorities;Site;Social Characteristics;Specific qualifier value;Statistical Data Interpretation;Stress;Subgroup;substance misuse;substance use;symposium;Techniques;therapy design;Time;trait;Translating;United States Substance Abuse and Mental Health Services Administration;university student;uptake;Urbanicity;vaping;vaping nicotine;webinar;young adult

PROJECT_TITLE: Promoting Rapid Uptake of Multilevel Latent Class Modeling via Best Practices: Investigating Heterogeneity in Daily Substance Use Patterns


ORG_CITY: CLEVELAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

ORG_STATE: OH

PHR: To improve human health, students must emerge from their scientific training with skills, which will enable them to address unmet health needs with effectiveness, efficiency and economy. To meet these needs, the Cleveland Kidney, Urology and Hematology Training Network will provide modern training for future scientists to address outcomes important to people with kidney, benign urinary and benign blood conditions and cure these diseases.

PI_NAMEs: BORON, WALTER F;SEDOR, JOHN R. (contact)

PROGRAM_OFFICER_NAME: SADUSKY, ANNA BURKART

PROJECT_TERMS: Acceleration;Address;Adopted;Advisory Committees;Advocate;Benign;Blood;career;Clinic;Clinical;Collaborations;collaborative environment;Communication;Communities;Community Networks;Community of Practice;community setting;Competence;design;Development;Diabetes Mellitus;Digestive System Disorders;Disease;diversity and inclusion;Doctor of Philosophy;Ecosystem;Education;Effectiveness;Ensure;Evaluation;Event;expectation;Face;Faculty;Foundational Skills;Future;Hand functions;Health;Health Sciences;Health system;Hematological Disease;Hematology;high school;Human;improved;Infrastructure;innovation;Institution;Interdisciplinary Education;interest;Investments;Kidney;Kidney Diseases;Knowledge;Laboratories;Learning;Medical center;meetings;Mentors;Mentorship;Methodology;migration;minority health;Mission;Modeling;Modernization;multidisciplinary;Office of Administrative Management;Outcome;outreach program;peer;Persons;Postdoctoral Fellow;pre-doctoral;Professional Practice;Program Evaluation;programs;Public Health;Recording of previous events;Research;Research Project Grants;Research Training;response;Scientific Inquiry;Scientist;Services;skills;social;Students;success;System;Teacher Professional Development;TNFSF15 gene;tool;Training;Training Programs;Translational Research;Translations;undergraduate student;Underrepresented Populations;United States Department of Veterans Affairs;Universities;University Hospitals;urinary;Urologic Diseases;Urology;virtual platform;Work


NIH_SPENDING_CATS: Hematology;Kidney Disease

PI_NAMEs: SEDOR, JOHN R. (contact)

PROJECT_TERMS: Admission activity;Advisory Committees;Applications Grants;Area;Atmosphere;authority;Basic Science;Biological Sciences;Biomedical Research;Boron;Characteristics;Clinic;Clinical Research;cohort;Collaborations;Communication;Communities;Community Networks;Community of Practice;Core Facility;Databases;Dedications;Development;Discipline;Disputes;Doctor of Philosophy;Ecosystem;Education Projects;Electronic Mail;Environment;Evaluation;experience;Faculty;Feedback;Friends;Hematology;high school;Home;improved;Institution;inter-institutional;Intervention;junior high school;Kidney;Medical;Medical center;medical schools;meetings;member;Mentors;Methods;minority student;Monitor;multidisciplinary;Names;Nephrology;novel;Oral;organizational structure;Physiology;Postdoctoral Fellow;pre-doctoral;Program Evaluation;programs;Publications;recruit;Reporting;Research;Research Personnel;Resolution;Resources;social media;Structure;TNFSF15 gene;Training;Training and Education;Training Programs;Translational Research;undergraduate student;Underrepresented Populations;United States Department of Veterans Affairs;Universities;University Hospitals;Urology;virtual platform;web site;Writing

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Aging;Bioengineering;Biotechnology;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: LOS ANGELES

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE Mesenchymal stromal cells are promising therapeutic cells that may treat many challenging diseases, yet very difficult to produce as they often rapidly age and lose their therapeutic functions during expansion. This proposal will develop an AI-based method for designing the drugs that can delay the MSC aging process by controlling the biochemical signaling of the MSCs. Upon completion, this proposal will enable us to produce highly therapeutic potent MSCs in a reproducible manner and advance fundamental understandings in aging signaling of MSCs.

PI_NAMEs: LIN, NEIL  (contact)

PROGRAM_OFFICER_NAME: WANG, PEGGY

PROJECT_TERMS: Address;Age;Aging;aging process;Algorithms;artificial intelligence method;artificial intelligence model;Artificial Intelligence platform;Biochemical;Black Box;Cell Aging;Cell Therapy;Cells;cellular engineering;Characteristics;Clinical;DDR2 gene;deep learning;deep learning model;design;Disease;Drug Design;EGF gene;Engineering;Ensure;Fibroblast Growth Factor;FRAP1 gene;Gene Expression;Genetic Transcription;Goals;improved;In Vitro;in vivo;innovation;Knowledge;mesenchymal stromal cell;Metabolic;Morphology;Outcome;Phenotype;Process;Proliferating;Rejuvenation;Reproducibility;Research;response;senescence;Signal Pathway;Signal Transduction;Technology;Therapeutic;tool;Training;training data

PROJECT_TITLE: AI-informed Signaling Factor Design for in vitro Rejuvenating Mesenchymal Stromal Cells

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


PI_NAMEs: DAMASER, MARGOT S. (contact)

PROJECT_TERMS: Academic achievement;Area;Award;Awareness;Basic Science;Big Data;career;career networking;Clinical;Clinical Research;cloud based;Communication;Community of Practice;Data Storage and Retrieval;Development;didactic education;diversity and inclusion;Doctor of Philosophy;Education;Educational Curriculum;Educational workshop;Ensure;Entrepreneurship;Environment;Evaluation;experience;Exposure to;Faculty;Fostering;Future;Goals;Grant;Growth;Hematology;Individual;innovative technologies;insight;Institution;interdisciplinary approach;interest;Kidney;Knowledge;Knowledge acquisition;Laboratories;Leadership;Learning;LinkedIn;Measurement;meetings;member;Mentors;Oral;Paper;Positioning Attribute;Procedures;Productivity;Program Evaluation;programs;Publications;Reporting;Research;Research Personnel;Resources;Scientist;Self-Evaluation Programs;Self-Examination;senior faculty;shared database;skills;social media;statistics;Structure;Technology;TNFSF15 gene;Training;Training Programs;Translational Research;translational scientist;Twitter;Urology;web site;Writing

PROJECT_TITLE: KUH-TN Professional Development Core


NIH_SPENDING_CATS: Behavioral and Social Science;Hematology;Kidney Disease;Pediatric

PI_NAMEs: DOBRE, MIRELA AURORA (contact)

PROJECT_TERMS: Address;apprenticeship;Award;Awareness;Biological Sciences;career;career networking;Clinic;Clinical Research;cohort;college;Communication;Communities;community college;Community of Practice;Community Outreach;Competence;design;Disease;Doctor of Philosophy;Education;Educational process of instructing;Ensure;Event;experience;Faculty;Fellowship;Fostering;Future;Geography;Goals;Grant;Health;Healthcare;Hematology;high school;Incubators;innovation;Institution;interest;Internal Medicine;Internet;K-Series Research Career Programs;Kidney;Knowledge;Learning;Link;Love;Medical center;member;Mentors;Mission;Modeling;Municipalities;Nephrology;novel;Outcome;outreach;outreach program;Pathway interactions;peer;peer coaching;peer networks;peer support;Persons;Problem Solving;Process;programs;recruit;Research;Research Activity;Residencies;Schedule;school district;Science;Science, Technology, Engineering and Mathematics Education;Secure;Series;skills;social;Solid;Structure;Students;summer internship;summer research;summer student;Support System;System;Technical Expertise;Technology;TNFSF15 gene;Training;Training Programs;Translational Research;Trust;undergraduate student;Underrepresented Populations;United States National Institutes of Health;Universities;University Hospitals;Urology;virtual;web page

PROJECT_TITLE: KUH-TN Networking Core


ORG_CITY: BOSTON

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

ORG_STATE: MA

PHR: Project Narrative The current epidemic of obesity and diabetes sweeping the American populace has heightened the need for well-trained academic endocrinologists who can address the problem with clinical, translational, and basic science approaches. The Endocrine Training Program at the Beth Israel Deaconess Medical Center has a long record of accomplishment in producing such scientists. The undiminished tide of metabolic disease underscores the importance of continuing the vital activities of this Training Program.

PI_NAMEs: KAHN, BARBARA B. (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Endocrine;Metabolic;Research Training

PROJECT_TITLE: Integrated Endocrine and Metabolic Research Training

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE Violence imposes huge risk to our society and our inability to control excessive aggression stems from our ignorance of its generation and modulation. The goal of our study is to understand how social experiences alter the brain’s aggression circuit and lead to changes in aggressive behaviors. A better understanding of the neural underpinnings of natural variation in aggression may lead to novel strategies to specifically treat excessive aggression.

PI_NAMEs: LIN, DAYU  (contact)

PROGRAM_OFFICER_NAME: BREEDEN, ANDREW LEE

PROJECT_TERMS: Address;Aggressive behavior;Amygdaloid structure;Animals;Automobile Driving;Behavior;biophysical properties;Biophysics;Brain;Brain region;Cells;Chemosensitization;Communication;Cues;Data;Development;ESR1 gene;Event;experience;experimental study;Fiber;fighting;Future;Generations;Genetic;Glutamates;Goals;Gonadal Steroid Hormones;Homosynaptic Depression;Hormonal;Human;Hypothalamic structure;Immediate-Early Genes;In Vitro;in vivo;in vivo monitoring;Inbred Mouse;Individual;individual variation;insight;Instinct;Investigation;Ions;Learning;Long-Term Depression;Long-Term Potentiation;male;Mediating;Motor;Motor Pathways;Mus;Mutagenesis;neural;neuromechanism;Neurosciences;novel strategies;Output;patch clamp;Pathway interactions;Patients;pharmacologic;Phase;Population;Property;Protocols documentation;Readiness;Research;Resources;response;Risk;Role;Secure;Sensory;Series;Site;Slice;social;Social Behavior;Social Interaction;Societies;stem;Stereotyping;Synapses;Synaptic plasticity;Synaptic Transmission;Testing;Variant;Violence;willingness

PROJECT_TITLE: The Neural Mechanisms of Winner and Loser Effect

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


NIH_SPENDING_CATS: Aging;Biotechnology;Physical Activity;Regenerative Medicine;Sarcopenia;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: PROJECT NARRATIVE Elderly individuals are susceptible to injury and have reduced capacity to repair injured muscle, ultimately leading to muscle weakness and loss of physical activity. By using biochemistry, cell and molecular biology, genome editing, and in vivo animal models, our proposed studies shall provide critical insights into the biology underlying diminished myokine function of MG53 in muscle aging and the potential of rejuvenating muscle satellite cells with inducible secretion of MG53 to enhance muscle repair and regeneration for treating aging-related muscle dysfunction.

PI_NAMEs: MA, JIANJIE  (contact);PARK, KI HO ;ZHOU, JINGSONG ;ZHU, HUA

PROGRAM_OFFICER_NAME: BOYCE, AMANDA T

PROJECT_TERMS: Adverse effects;Age;Age Months;age related;age-related muscle loss;aged;Aging;aging related;Animal Model;animal old age;Anti-Inflammatory Agents;Area;Attenuated;Benefits and Risks;Biochemistry;Biology;Blood Circulation;Cell Physiology;Cellular biology;Chronic;Circulation;Clustered Regularly Interspaced Short Palindromic Repeats;Data;Dose;Doxycycline;Elderly;Exercise;exosome;Foundations;Functional disorder;gene editing technology;Genes;genome editing;Goals;Human;Impairment;improved;in vivo;Individual;Inflammation;Injury;injury and repair;insight;Knock-in Mouse;life span;live cell imaging;Manuscripts;Measurable;Mediating;member;microvesicles;Molecular;Molecular Biology;mouse model;Mus;Muscle;muscle aging;Muscle function;muscle regeneration;muscle repair;Muscle satellite cell;muscle transplantation;Muscle Weakness;Muscular Atrophy;muscular system;Nature;normal aging;old mice;Organ;Outcome Study;Oxidative Stress;Pathology;Persons;Physical activity;Physical Function;Pilot Projects;Play;Post-Translational Protein Processing;Predisposition;preservation;Proliferating;Protein Family;Proteins;Proteomics;Publishing;Recombinants;regeneration following injury;Regenerative capacity;Regenerative Medicine;regenerative tissue;Rejuvenation;repair function;repaired;Research;Research Design;response;Role;Sarcolemma;Sentinel;Serum;Skeletal Muscle;Skeletal Muscle Satellite Cells;Stains;Stress;Testing;Therapeutic;tissue injury;tissue regeneration;tissue repair;Tissues;Transgenic Mice;Translating;TRIM Gene;Wild Type Mouse;wound healing

PROJECT_TITLE: MG53 function in muscle aging


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Bioengineering;Biotechnology;Chronic Liver Disease and Cirrhosis;Complementary and Integrative Health;Dietary Supplements;Digestive Diseases;Genetics;Hepatitis;Liver Disease;Microbiome;Nutrition;Substance Misuse

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

PHR: The goals of this project are to investigate the mechanisms of gut-derived microRNA in liver bile acid and lipid synthesis. This study will have a major impact on the development of a probiotics-based new therapeutic strategy for the prevention and treatment of alcohol-associated liver disease.

PI_NAMEs: FENG, WENKE  (contact)

PROGRAM_OFFICER_NAME: WANG, JOE

PROJECT_TERMS: absorption;alcohol abuse therapy;Alcoholic Hepatitis;Alcoholic Liver Diseases;Alcohols;Animal Model;Attenuated;Bile Acid Biosynthesis Pathway;Bile Acids;Binding;Biological Markers;Biological Process;Cessation of life;Cholestasis;Clinical Research;Clinical Trials;Communities;Data;Detergents;Development;Down-Regulation;Enzymes;Epithelial Cells;Evaluation;Exhibits;exosome;Fatty acid glycerol esters;Fatty Liver;FDA approved;Feces;feeding;FGF19 gene;Fibroblast Growth Factor;Fibroblast Growth Factor Receptors;Genetic Transcription;Goals;gut microbiome;gut microbiota;Hepatic;Hepatitis;Hepatocyte;Homeostasis;Hormones;Human;improved;interest;intestinal epithelium;Intestines;Knock-out;Knowledge;Lactobacillus casei rhamnosus;Ligands;lipid biosynthesis;Lipids;Liver;Liver diseases;liver injury;Mediating;Medical;MicroRNAs;Molecular;mouse model;mRNA Expression;Mus;nanoparticle;novel therapeutic intervention;Nuclear Receptors;overexpression;Pathology;Pathway interactions;Patients;pharmacologic;Play;posttranscriptional;Prevention strategy;probiotic supplementation;probiotic therapy;Probiotics;Property;protective effect;receptor;Receptor Activation;Regulation;Reporting;Role;Sampling;Serum;Signal Transduction;Signaling Molecule;stool sample;Supplementation;Testing;Therapeutic;Transcriptional Activation;Translating;Treatment Efficacy;Urine

PROJECT_TITLE: Intestine FXR activation by LGG-derived nanoparticles in alcohol-associated liver disease

STUDY_SECTION: XNDA

STUDY_SECTION_NAME: Xenobiotic and Nutrient Disposition and Action Study Section[XNDA]


ORG_CITY: IRVINE

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: Project Narrative Our proposed project will expand our existing viral production facility at the UCI Center for Neural Circuit Mapping (CNCM) to support the production and distribution of BRAIN Initiative Armamentarium project reagents to the broad neuroscience community. We will advance the scientific and technical merit of the proposed project through expanded inclusivity.

PI_NAMEs: FISHELL, GORDON J;XU, XIANGMIN  (contact)

PROGRAM_OFFICER_NAME: KIM, DOUGLAS SUN-IL

PROJECT_TERMS: adeno-associated viral vector;Aliquot;Asian Americans;Award;Brain;brain cell;brain circuitry;BRAIN initiative;California;Capsid;cell community;cell type;Cells;Cerebral cortex;Charge;Collaborations;Communities;cost;Custom;Dependovirus;design;designer receptors exclusively activated by designer drugs;Development;diversity and inclusion;Enhancers;Ensure;excitatory neuron;Exclusion;experience;Faculty;Funding;Gene Delivery;Gene Expression;Genes;Genetic;Goals;Grant;Hand;Health Sciences;Hispanic-serving Institution;Human;improved;In Vitro;in vivo;inhibitory neuron;Institution;Interneurons;Maps;member;minority communities;minority trainee;Minority-Serving Institution;Modeling;Molecular;Monkeys;Morehouse School of Medicine;Mus;Native Americans;neural circuit;Neurons;Neurosciences;neurotropic virus;nonhuman primate;novel;Pacific Island Americans;Participant;Production;Qualifying;Quality Control;Reagent;Recombinant adeno-associated virus (rAAV);Recovery;recruit;Regulatory Element;Reporter;Reproducibility;Research;Research Personnel;Research Project Grants;Resolution;Resources;response;Rodent;scale up;Scientific Advances and Accomplishments;Scientist;screening;Serotyping;Services;Students;Technology;tool;Underrepresented Minority;underrepresented minority student;United States National Institutes of Health;Universities;Validation;vector;Viral;Viral Vector;Virus;virus genetics;Work

PROJECT_TITLE: UC Irvine Center for the production and distribution of cell-type-specific viral targeting reagents


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Clinical Research;Hematology;Infectious Diseases;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Sepsis

ORG_CITY: Boxborough

ORG_NAME: HELIXBIND, INC.

PHR: PROJECT NARRATIVE Neonatal sepsis, induced by a microbial infection of the bloodstream, is a serious and life-threatening disease. Timely diagnosis, identification of the etiological agent supporting administration of appropriate antimicrobials is critical for successful outcomes for these vulnerable patients. Unfortunately, current best practices are far too slow in identifying the infection and often fail due to the presence of maternal antibiotics. HelixBind has developed a diagnostic test allowing the detection and identification of the infection’s etiological agent both days faster than currently possible as well as in the presence of common antimicrobials. The efforts described in this proposal will advance the maturity of the product culminating in an in-hospital study mirroring that which will be completed for FDA clearance. Success in this program will result in a critically needed diagnostic device, ready for manufacturing scale up as required for FDA trials and market launch.

PI_NAMEs: SINGER, ALON  (contact)

PROGRAM_OFFICER_NAME: MINNICOZZI, MICHAEL

PROJECT_TERMS: Accounting;accurate diagnosis;Address;Adopted;Adult;Affect;Antibiotics;antimicrobial;Antimicrobial Resistance;assay development;Biological Assay;Birth;Blood;Blood specimen;Blood Volume;Breakthrough device;Budgets;Chicago;Childhood;Clinic;Clinical;Clinical assessments;Clinical Microbiology;Clinical Research;commercialization;Communicable Diseases;cost;cross reactivity;Data;design;Detection;Development;Diagnosis;Diagnostic;diagnostic assay;Diagnostic Equipment;diagnostic platform;diagnostic strategy;Diagnostic tests;Disease;DNA sequencing;Early Diagnosis;Ensure;Etiology;Evidence based treatment;Exhibits;experience;Feedback;Hospitals;Hour;in-vitro diagnostics;Infection;innovation;instrument;instrumentation;Intervention;intrapartum;Laboratories;Life;Live Birth;manufacture;manufacturing scale-up;Marketing;Medical center;meetings;member;Methods;microbial;microbiome;Molecular;Morbidity - disease rate;mortality;Neonatal Mortality;neonatal sepsis;neonate;Newborn Infant;Outcome;outcome prediction;pathogen;pathogenic bacteria;pathogenic fungus;patient population;Patients;Pediatric Hospitals;Performance;performance tests;Phase;Population;Positioning Attribute;Preparation;Process;product development;programs;Regulatory Pathway;Resistance;Resistance development;resistance gene;Risk;Sampling;Sensitivity and Specificity;Sepsis;side effect;Specific qualifier value;Specificity;Stress;success;System;systemic inflammatory response;Technology;Temperature;Testing;Time;timeline;University Hospitals;Whole Blood;Work

PROJECT_TITLE: Direct from blood identification of bloodstream infections in newborns