ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Infectious Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: INDIANAPOLIS

ORG_DEPT: DENTISTRY

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Project Narrative The goal of this project is to identify the novel role of osteocytes as inflammatory cells and determine the mechanism by which osteocyte inflammation regulates immune cell activation and bone resorption. Successful investigation will bring new therapies for bone destruction in bacterial bone diseases, such as osteomyelitis and periodontitis.

PI_NAMEs: UEKI, YASUYOSHI  (contact)

PROGRAM_OFFICER_NAME: WAN, JASON

PROJECT_TERMS: Affect;alveolar bone;Alveolar Bone Loss;Animals;Antibiotics;Bacteria;Bacterial Infections;bone;Bone Diseases;Bone Resorption;Bone Surface;Bone Tissue;Calvaria;CCL2 gene;CCL3 gene;cell motility;cell type;Cells;chemokine;curative treatments;CXCL1 gene;Data;dentin matrix protein 1;Disease;Drug Targeting;Etiology;Excision;Exhibits;Genes;Gingiva;Goals;Immune;immune activation;In Vitro;in vivo;Infection;Inflammation;Inflammation Mediators;Inflammatory;Inflammatory Infiltrate;inhibitor;Interleukin-1 beta;Interleukin-6;Investigation;Lesion;Macrophage;Mediating;Molecular;Mus;Myelogenous;neutrophil;novel;novel therapeutic intervention;novel therapeutics;Oral;Osteitis;osteoclast progenitor;Osteoclasts;Osteocytes;Osteolysis;Osteomyelitis;Osteoporosis;pathogen;Pathway interactions;Periodontitis;pharmacologic;Porphyromonas gingivalis;Reaction;Regulation;response;restoration;Role;Signal Pathway;Signal Transduction;Skeleton;stem cells;subcutaneous;Surface;Testing;therapeutic target;TLR2 gene;TNF gene;TNFSF11 gene

PROJECT_TITLE: Mechanisms of osteocyte induction and regulation of pathogen-induced osteolysis

STUDY_SECTION: SBDD

STUDY_SECTION_NAME: Skeletal Biology Development and Disease Study Section[SBDD]


ADMINISTERING_IC: GM

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Cannabinoid Research;Cardiovascular;Endocannabinoid System Research;Kidney Disease;Lung;Nanotechnology;Neurosciences

ORG_CITY: BERKELEY

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOCHEMISTRY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

ORG_STATE: CA

PHR: PROJECT NARRATIVE Ion channel proteins underlie neuronal communication, organ function, environmental sensation, and many other physiological processes. The specific ion channels being investigated here are involved in breathing control, kidney function, and heart rate regulation; are disrupted genetically in inherited forms of renal failure, cardiac arrythmias, and pulmonary hypertension; and are targets of anesthetics, antiarrhythmics, and drugs to treat sleep apnea. Studying how these channels operate and are regulated will lead to a better understanding of their physiological roles and the development of more potent and specific therapeutics that target ion channels to promote health and treat disease.

PI_NAMEs: BROHAWN, STEPHEN GRAF (contact)

PROGRAM_OFFICER_NAME: NIE, ZHONGZHEN

PROJECT_TERMS: Acids;Address;anandamide;Anesthesia procedures;Anesthetics;Anti-Arrhythmia Agents;Architecture;base;Binding Sites;Biological;Biological Assay;Biology;blood pressure control;blood pressure regulation;Breathing;Bupivacaine;Cardiac;Cell membrane;Cells;Cellular Membrane;Chemicals;Communication;comparative;Complex;Coupled;Cryoelectron Microscopy;Cytoplasm;design;Development;Diffusion;Disease;Drug Targeting;Electrophysiology (science);Endocannabinoids;Environment;Esthesia;extracellular;Family;Feedback;Generations;Goals;GTP-Binding Proteins;Health Promotion;Heart Rate;heart rhythm;Human;Hypertension;Hypokalemia;Inherited;insight;Investigation;Ion Channel;Ion Channel Protein;Ions;Kidney Diseases;Kidney Failure;Lipid Binding;Lipids;Mammals;Mediating;member;Membrane;Membrane Potentials;Membrane Proteins;Methodology;Modeling;Molecular;Molecular Conformation;mutant;Mutation;nanodisk;Nature;Neurons;Obstructive Sleep Apnea;Organ;pH Homeostasis;Pharmaceutical Preparations;pharmacologic;Phosphatidylinositols;physical model;Physiological;Physiological Processes;Play;Potassium Channel;Process;programs;Property;Protein Subunits;Proteins;Protons;Pulmonary Hypertension;receptor;Receptor Signaling;reconstitution;Regulation;Renal function;Research;respiratory;Rest;Role;Side;Signal Transduction;Sleep Apnea Syndromes;small molecule;Stimulus;Structure;targeted agent;Testing;therapeutic target;Volatilization;voltage;Work

PROJECT_TITLE: Structural basis for K2P channel gating and modulation

STUDY_SECTION: BBM

STUDY_SECTION_NAME: Biochemistry and Biophysics of Membranes Study Section[BBM]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF EDUCATION

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Clinical Research;Mental Health;Neurosciences;Pediatric

ORG_CITY: COLLEGE PARK

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

ORG_STATE: MD

PHR: Project Narrative Behavioral inhibition is a type of infant temperament that predisposes children to future anxiety difficulties. This project seeks to understand what and how 9- to 11-year-old children’s self-regulation skills and related brain activity may increase or decrease this future anxiety risk. Such knowledge will allow the identification of children who may benefit from intervention and will allow the development of new prevention and treatment options for these children.

PI_NAMEs: VALADEZ, EMILIO ALEJANDRO (contact)

PROGRAM_OFFICER_NAME: BECHTHOLT, ANITA JEAN

PROJECT_TERMS: 11 year old;Acceleration;Adolescence;Adult;age group;analytical method;Anxiety;behavior influence;Behavioral;Behavioral inhibition;Brain;Brain region;career;Child;Childhood;Clinical;Cognitive;cognitive control;Conflict (Psychology);control theory;Coupled;Data;design;Detection;Development;Dissociation;Distress;Electroencephalography;Emotional;Emotional disorder;Environment;experience;follow-up;Fostering;Functional Magnetic Resonance Imaging;functional magnetic resonance imaging/electroencephalography;Funding;Future;Goals;high risk;improved;individual variation;Infant;infant temperament;Informal Social Control;Intercept;Intervention;Knowledge;Learning;Life;longitudinal design;Measurement;Measures;middle childhood;Modeling;neural;Neurocognitive;neuroimaging;neuromechanism;novel;novel therapeutics;Outcome;Parietal Lobe;Participant;Population;predictive modeling;prevent;Prevention;Process;programs;prospective;Questionnaires;Recording of previous events;recruit;Research;Research Personnel;Research Proposals;Resources;Risk;risk prediction;Sampling;Short-Term Memory;skills;Source;source localization;Specificity;Statistical Data Interpretation;Techniques;Temperament;temporal measurement;Testing;Time;Toddler;Training;Training Programs;United States National Institutes of Health;Work;Youth

PROJECT_TITLE: Neurocognitive Predictors of Anxiety Risk Among Behaviorally Inhibited Children

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


ADMINISTERING_IC: AR

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Arthritis;Chronic Pain;Clinical Research;Osteoarthritis;Pain Research;Physical Injury - Accidents and Adverse Effects;Rehabilitation

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE There is a poor understanding of tendon healing in humans, which has led to a disconnect between the way treatments are designed for overuse tendon injuries and their use in clinical practice, placing patients at risk for long-lasting impairments, injury recurrence, impaired function, and decreased quality of life. Graft harvest (removing a portion of the tendon to use in another area of the body) provides an opportunity to improve our understanding of tendon healing and narrow the gap between research and clinical practice. Long-term, this will allow us to design better treatments and measures of treatment effectiveness, which will accelerate and enhance recovery from overuse tendon injuries.

PI_NAMEs: SPRAGUE, ANDREW L (contact)

PROGRAM_OFFICER_NAME: WASHABAUGH, CHARLES H

PROJECT_TERMS: Acceleration;Address;Adoption;Animal Model;anterior cruciate ligament reconstruction;Area;Autologous Transplantation;Basic Science;Biology;career;Clinic;Clinical;clinical examination;clinical practice;Clinical Research;Clinical Trials;cohort;Cumulative Trauma Disorders;Data;design;Development;Development Plans;dosage;elastography;Evaluation;experience;Goals;Harvest;healing;high risk;Hip Osteoarthritis;Human;Impairment;improved;Injury;innovation;Intervention;Investigation;Isometric Exercise;Knee Osteoarthritis;Knowledge;Lateral;Lead;Lower Extremity;Measures;mechanical properties;Mentorship;Methods;Modeling;Multicenter Studies;Outcome;Outcome Measure;Pain;Participant;Patient Outcomes Assessments;Patients;Performance;preservation;prevent;Property;prospective;Prospective, cohort study;Proxy;quadriceps muscle;Quality of life;Randomized;Recovery;Recurrence;Rehabilitation therapy;Research;Research Activity;Residual state;Resolution;Risk;Scientist;sedentary;Severities;Site;Societies;Speed;Standardization;Structure;Study models;Symptoms;tendon development;tendon graft;Tendon Injuries;Tendon structure;Testing;therapy design;Thick;Time;Tissues;Training;Treatment Effectiveness;treatment optimization;Treatment outcome;Ultrasonography;unethical;Universities

PROJECT_TITLE: Graft harvest as a model of tendon injury; Trajectory of recovery and clinical outcomes

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Hematology

ORG_CITY: SAINT LOUIS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Blood diseases like leukemia, sickle cell disease, anemia, venous thrombosis, and stroke affect millions of peo- ple in the U.S. The goal of this grant is to train a new generation of scientists who will make discoveries that enable us to diagnose, treat, and perhaps cure these diseases.

PI_NAMEs: OH, STEPHEN TRACY (contact)

PROGRAM_OFFICER_NAME: HILL-PRYOR, CRYSTAL DARLEANE-ROBIN

PROJECT_TERMS: molecular hematology;Training

PROJECT_TITLE: Pre-and Postgraduate Training in Molecular Hematology

STUDY_SECTION: NITM

STUDY_SECTION_NAME: NHLBI Institutional Training Mechanism Study Section[NITM(OA)]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Mental Health;Neurosciences

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC

ORG_STATE: NY

PHR: BDNF and other neurotrophins have widespread and powerful roles in the mammalian nervous system, and are thought to be involved in a number of psychiatric and neurological disorders. However, how neurotrophins function at the cellular and synaptic levels is not well understood. This project will explore the hypothesis that a BDNF ortholog and its Trk receptor are key components in two synaptic feedback loops that underly consolidation of long-term synaptic plasticity and memory, and may suggest how dysfunctions of those loops could contribute to psychiatric and neurological disorders.

PI_NAMEs: HAWKINS, ROBERT D (contact)

PROGRAM_OFFICER_NAME: TYLER, WILLIAM A

PROJECT_TERMS: Address;Afferent Neurons;Alzheimer's Disease;Animals;Aplysia;Association Learning;autocrine;Autocrine Communication;Behavioral;Brain-Derived Neurotrophic Factor;Cell Culture System;Cell Culture Techniques;Cell Separation;Disease;Drug Addiction;Feedback;Functional disorder;Gene Expression Regulation;Growth;habituation;Huntington Disease;Learning;Ligands;Mammals;Memory;Mental Depression;Mental disorders;Molecular;Motor Neurons;Nervous System;Nervous System Disorder;Neurodevelopmental Disorder;Neurons;neurotrophic factor;novel;Orthologous Gene;Parkinson Disease;Physiological;Play;postsynaptic;postsynaptic neurons;Preparation;presynaptic;Protein Isoforms;receptor;Reflex action;Rett Syndrome;Role;Schizophrenia;Sensory;Signal Transduction;Source;Synapses;Synaptic plasticity;System;Testing;tool;Varicosity;Withdrawal

PROJECT_TITLE: Neurotrophins and Consolidation of Learning-Related Synaptic Plasticity

STUDY_SECTION: LAM

STUDY_SECTION_NAME: Neurobiology of Learning and Memory Study Section[LAM]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Health Services;Neurodegenerative;Neurosciences;Palliative Care

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE Millions of Americans have late-stage Alzheimer’s and related dementias (ADRD), causing suffering due to loss of awareness of self and family, progressive dependency, physical and neuropsychiatric symptoms, and physical, emotional and financial strain for caregivers. We now propose a multi-site randomized clinical trial of the ADRD Palliative Care (ADRD-PC) program for persons with late-stage ADRD and their family caregivers, triggered during hospitalization. We aim to learn if this program of dementia-specific palliative care, standardized caregiver education, and transitional care is effective to reduce burdensome hospital transfers, improve symptom treatment and control, augment supportive services, and reduce nursing home transitions for patients, and to improve caregiver outcomes of communication, shared decision-making and distress.

PI_NAMEs: HANSON, LAURA C (contact)

PROGRAM_OFFICER_NAME: FAZIO, ELENA

PROJECT_TERMS: Acute;Address;advanced dementia;advanced directive;Affect;Alzheimer's Disease;Alzheimer's disease related dementia;American;arm;Awareness;caregiver education;caregiver strain;Caregivers;Caring;case finding;Colorado;Communication;Communities;comorbidity;cost;Decision Making;Dehydration;Dementia;Dementia caregivers;dementia caregiving;Dependence;design;Distress;Education;Educational Materials;Elderly;Emergency department visit;Emotional;end of life;Enrollment;Equipment and supply inventories;experience;fall injury;Family;Family Caregiver;Financial Hardship;General Hospitals;Geography;Goals;Health care facility;Healthcare;Home;hospice environment;hospice utilization;Hospitalization;Hospitals;improved;improved outcome;indexing;Indiana;Infection;Intervention;Learning;Length of Stay;Massachusetts;member;neuropsychiatric symptom;neuropsychiatry;Nomads;North Carolina;novel;Nursing Homes;Outcome;palliative;Palliative Care;patient oriented;Patient-Focused Outcomes;Patients;Persons;physical symptom;primary outcome;Prognosis;prognostic;programs;Quality of Care;Quality of life;Questionnaires;Randomized;randomized, clinical trials;Rapid screening;Reporting;Research;Science;secondary outcome;Self Perception;Services;shared decision making;Site;Standardization;symptom management;symptom treatment;symptomatic improvement;Symptoms;System;Testing;treatment arm;Universities

PROJECT_TITLE: Palliative Care for Persons with Late-stage Alzheimer's and Related Dementias and their Caregivers: a Randomized Clinical Trial

STUDY_SECTION: CMPC

STUDY_SECTION_NAME: Clinical Management of Patients in Community-based Settings Study Section[CMPC]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Genetics;Infectious Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Substance Misuse

ORG_CITY: LEXINGTON

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: PROJECT NARRATIVE/RELEVANCE Approximately 7% of alcohol users engage in chronic heavy drinking (CHD), which is associated with increased risk of bacterial and viral infections as well as decreased tissue repair ability. These observations suggest a failure of innate immune cells to perform their functions. The proposed research aims to identify CHD-mediated functional, transcriptomic, and epigenetic alterations in monocytes and their progenitors in the bone marrow, with the goal of better understanding the etiology of reduced immune fitness.

PI_NAMEs: MESSAOUDI, ILHEM  (contact)

PROGRAM_OFFICER_NAME: LIN, LI

PROJECT_TERMS: Abstinence;Address;Adverse event;alcohol availability;Alcohol consumption;alcohol effect;Alcoholic Liver Diseases;Alcohols;Animals;antimicrobial;Area;ATAC-seq;Bacterial Infections;Biological Assay;Biological Response Modifiers;Biology;Blood;Blood specimen;Bone Marrow;cancer type;Cardiovascular Diseases;Categories;Cell Line;Cells;Chromatin;Chronic;chronic alcohol ingestion;Chronic Disease;Communicable Diseases;comparison control;Complex;cytokine;Data;data integration;Defect;Development;Dose;drinking behavior;Environment;Epigenetic Process;epigenome;Ethanol;Etiology;Event;experimental study;Failure;Female;fitness;Gene Expression;Genetic Transcription;Goals;Health;Heavy Drinking;Hematopoietic;Hematopoietic stem cells;Heterogeneity;histone modification;Homeostasis;Host Defense;Housing;Human;Immune;immune activation;Immune Tolerance;Immunity;Immunocompetence;Immunologics;Immunology procedure;Impaired wound healing;improved;In Vitro;in vivo;in vivo Model;Individual;Infection;Inflammation Mediators;Inflammatory;Inflammatory Response;insight;Intercistronic Region;Intervention;Knowledge;Link;Macaca;Macaca mulatta;Macrophage;male;Mediating;Metabolic;Metabolism;migration;Modeling;monocyte;Myeloid Cells;Myeloid Progenitor Cells;Myelopoiesis;Natural Immunity;next generation sequencing;nonhuman primate;novel;Outcome;pathogen;Patients;Peripheral;peripheral blood;Peripheral Blood Mononuclear Cell;Phenotype;Physiology;Population;Postoperative Period;Predisposition;progenitor;programs;Promoter Regions;Reporting;Research;Respiratory Tract Infections;response;Risk;Sampling;Self Administration;single cell analysis;single-cell RNA sequencing;stem cells;Testing;therapy design;tissue repair;Tissues;transcriptome;transcriptomics;Virus Diseases;wound healing

PROJECT_TITLE: Impact of chronic alcohol consumption on the functional and epigenetic landscapes of monocytes and their progenitors

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: ATLANTA

ORG_NAME: GEORGIA STATE DEPARTMENT OF AGRICULTURE

ORG_STATE: GA

PHR: Georgia Department of Agriculture Project Title: Maintenance of the Animal Feed Regulatory Program Standards and the Coordinated Preventive Control Regulatory Activities and Capacity Building Project Period: September 1, 2020 – August 31, 2025 Project Narrative The mission of the Georgia Department of Agriculture (GDA) is to protect consumers, promote agriculture both locally and globally and assist our customers using education, technology, and a professional workforce. The GDA will use the Animal Feed Regulatory Program Standards (AFRPS) Maintenance Phase Track and the Preventive Controls for Animal Food (PCAF) funding option to continue development of a prevention-based animal food safety system to reduce the risk-factors that are known to cause or contribute to animal and human illness.

PI_NAMEs: WEAVER, REBECCA  (contact)

PROGRAM_OFFICER_NAME: CLARK, JACOB

PROJECT_TITLE: Maintenance of the Animal Feed Regulatory Program Standards and the Coordinated Preventive Control Regulatory Activities and Capacity Building (U18)


ORG_CITY: DES MOINES

ORG_NAME: IOWA DEPT AGRICULTURE/LAND STEWARDSHIP

ORG_STATE: IA

PHR: Iowa Department of Agriculture and Land Stewardship LFFM - Expanding Capabilities and Capacities Narrative This proposal supports an integrated food safety system through expanded microbiological and chemical testing of human and animal food. In addition to expanded testing, new methods will be implemented to add new capabilities and new equipment will be purchased to increase testing capacity. These activities will improve human and animal health by decreasing exposure to foodborne hazards.

PI_NAMEs: BANTA, MELANIE D (contact)

PROGRAM_OFFICER_NAME: LI, MEI-YING


ADMINISTERING_IC: VA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: Veterans Affairs

ORG_CITY: Decatur

ORG_NAME: VETERANS HEALTH ADMINISTRATION

PHR: Veterans bear a disproportionate burden of disability as a result of chronic limb threatening ischemia (CLTI) compared to their age-matched non-Veteran counterparts, often culminating in limb loss. Restoring of blood flow through surgery is the ideal treatment, however, not all Veterans are able to successfully undergo surgery to achieve this. New therapies aimed at local vascular regeneration to restore perfusion and function of the ischemic leg are paramount. This study aims to generate and embed clinical grade stem cell-derived endothelial cells in a resorbable platelet lysate hydrogel, and to implant these cells into ischemic mouse hindlimbs to quantify the restoration of perfusion and function. This is a critical step toward applying induced pluripotent stem cells to vascular regeneration to improve therapies for Veterans with CLTI.

PI_NAMEs: HEKMAN, KATHERINE ELIZABETH (contact)

PROJECT_TERMS: adult stem cell;Adverse event;adverse outcome;Affect;Age;allodynia;Amputation;Anatomy;Animal Model;Blood flow;Blood Platelets;Blood Vessels;Cell Aging;Cell Line;Cell Therapy;cell type;Cells;Chronic;Clinical;comorbidity;directed differentiation;disability;disability burden;Disease;Endothelial Cells;experience;Gait;Hindlimb;Human;Hydrogels;Immunosuppression;Implant;implantation;improved;In Vitro;in vivo;Inbred BALB C Mice;induced pluripotent stem cell;induced pluripotent stem cell technology;innovation;Ischemia;Isolated limb perfusion;Lasers;Leg;limb ischemia;limb loss;Limb structure;Lower Extremity;military veteran;Modality;Morbidity - disease rate;Mus;Neuronal Dysfunction;novel therapeutics;Nude Mice;old mice;Onset of illness;Operative Surgical Procedures;Pain;Pain management;Pain Measurement;pain reduction;palliation;patient derived induced pluripotent stem cells;Patients;Perfusion;perfusion imaging;Peripheral arterial disease;Persistent pain;Phenotype;Population;pre-clinical;Pre-Clinical Model;premature;prevent;Recovery;regenerative cell;regenerative therapy;Reproducibility;Rest;restoration;revascularization;Risk;Sampling;Serial Passage;Source;stem cell therapy;stem cells;Tactile;Technology;Testing;Therapeutic;Tissues;tool;Translating;Vascular Diseases;Vascular regeneration;Veterans;Walking;Work

PROJECT_TITLE: Applying induced pluripotent stem cell derived endothelial cells to regenerative therapy in chronic limb threatening ischemia

STUDY_SECTION: RRDS

STUDY_SECTION_NAME: Rehabilitation Research and Development SPiRE Program[RRDS]


ORG_CITY: IRVINE

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: PROJECT NARRATIVE    Heavy  metal  homeostasis  is  essential  for  normal  physiology,  whose  deregulation  is  associated  with  multiple  human  diseases.  Understanding the elaborate  response  system that  sequesters and  expels  overdosed heavy  metals  is  significant  for  human  health.  Our  proposed  research  will  focus  on  the  molecular  mechanisms  underlying  heavy  metal  response,  which  will  shed  lights  on  various  physiological  and  pathological  processes  involving heavy metals.

PI_NAMEs: WANG, WENQI  (contact);WARRIOR, RAHUL

PROGRAM_OFFICER_NAME: RIGAS, MARC

PROJECT_TERMS: Affect;Affinity;Apoptosis;Binding;Binding Sites;Biochemistry;Biological Assay;Blood;Cadmium;cell growth;Cell Physiology;Cell Survival;Cells;Cellular biology;Cessation of life;Child;Copper;cysteine rich protein;Cytoprotection;Data;Defect;Development;Disease;DNA Binding;Drosophila genus;Drug Metabolic Detoxication;Environment;experimental study;fly;Foundations;Functional disorder;Genes;Genetic Diseases;Genetic Transcription;Goals;Health;Heart;Heavy Metals;Homeostasis;Human;human disease;In Vitro;in vivo;Intestines;Intoxication;Ions;Iron;Kidney;Knock-out;Knowledge;Lead;Learning;Literature;Liver;Malignant Neoplasms;Mass Spectrum Analysis;Mediating;Memory;Mercury;Metallothionein;Metals;Methods;Molecular;Mutagenesis;mutant;Names;Nerve Degeneration;Nervous System;novel;novel therapeutic intervention;nuclear factor 1;Nuclear Translocation;Nucleic Acids;Organ;Organ Size;Overdose;Pathologic Processes;Pathway interactions;Phosphorylation;Phosphorylation Inhibition;Phosphorylation Site;Phosphotransferases;Physiological Processes;Physiology;Planet Earth;Play;Process;Proteins;reconstitution;Regulation;Research;response;Role;Series;Signal Pathway;Signal Transduction;Stimulation of Cell Proliferation;Stress;System;Testing;therapeutically effective;Tissues;Toxic effect;Toxic Environmental Substances;transcription factor;transcription factor MTF-1;Zinc

PROJECT_TITLE: Interplay of heavy metal homeostasis and cell growth-related signaling networks

STUDY_SECTION: CSRS

STUDY_SECTION_NAME: Cellular Signaling and Regulatory Systems Study Section[CSRS]


NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: In this project, we will provide an atomic level view, and mechanistic insights into the lytic transglycosylase peptidoglycan degrading multi-enzyme machines in the human pathogen Neisseria meningitidis. This project will use a multifaceted approach, that will apply tools of biochemistry, bacterial physiology, genetics, and structural biology; to define the dynamic interactions of these enzymatic machineries and elucidate their role in peptidoglycan formation as well as organelle assembly and insertion across the bacterial cell wall. We aim to define molecular interactions that could be used to develop the next generation of antibiotics aimed at treating infections caused by drug-resistant bacterial pathogens.

PI_NAMEs: WILLIAMS, ALLISON H (contact)

PROGRAM_OFFICER_NAME: BOND, MICHELLE RUEFFER

PROJECT_TERMS: Acetylesterase;Affinity Chromatography;analog;Antibiotics;antimicrobial;Bacteria;Bacterial Physiology;Binding;Binding Proteins;Biochemical;Biochemical Reaction;biochemical tools;Biogenesis;Biological;Biological Assay;Biophysics;Cell division;cell envelope;Cell Wall;Cells;Communication;Complement;Complex;Coupled;Cryoelectron Microscopy;Data;Development;drug development;Drug resistance;Enzymes;fighting;Future;Genetic;Goals;Gram-Negative Bacteria;Hot Spot;human pathogen;Hydrolysis;Infection;insight;Intracellular Transport;Lytic;macromolecule;Maps;Mass Spectrum Analysis;member;Membrane;Metabolic;Metabolism;Microbe;Modification;Molecular;Molecular Conformation;Motility;Multienzyme Complexes;nanobodies;nanomachine;Nature;Neisseria;Neisseria gonorrhoeae;Neisseria meningitidis;new therapeutic target;next generation;Organelles;particle;pathogen;pathogenic bacteria;Penicillin-Binding Proteins;Peptidoglycan;Peptidoglycan glycosyltransferase;Pilum;Polymerase;Polysaccharides;Positioning Attribute;Process;Productivity;protein complex;Protein-Protein Interaction Map;Proteins;Public Health;Resistance;Resolution;Role;Site;structural biology;Structure;Testing;Time;tool;Validation;Visualization;Work;X-Ray Crystallography

PROJECT_TITLE: Atomic-level probing of the peptidoglycan biosynthetic machinery in bacterial cell wall biogenesis

STUDY_SECTION: PCMB

STUDY_SECTION_NAME: Prokaryotic Cell and Molecular Biology Study Section[PCMB]


NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

ORG_CITY: Rockville

ORG_NAME: AMERICAN SOCIETY FOR CELL BIOLOGY

PHR: Project Narrative  The demographics of tenure-track biomedical faculty at research universities do not closely match those of the general US population, as women, some racial groups and disabled scientists are under-represented in the professoriate. Broadening participation by these groups is a national priority because it will ensure that the US captures as much of the research talent pool as possible and because it will make universities more equitable. To address this need, the American Society for Cell Biology’s AMP program will combine skills development workshops, mentor training and institutional culture-change initiatives at universities to support postdoctoral researchers from under-represented groups as they attain and thrive in tenure-track faculty positions.

PI_NAMEs: ALVANIA, REBECCA  (contact);BOYCE, MICHAEL S;MUNSON, MARY

PROGRAM_OFFICER_NAME: GIBBS, KENNETH D

PROJECT_TERMS: Address;Adopted;American;Biomedical Research;biomedical scientist;broadening participation research;career;Cellular biology;cohort;Communities;Country;demographics;design;Development;disabled;disparity elimination;educational atmosphere;Educational workshop;Ensure;Equity;evidence base;experience;Exposure to;Faculty;Funding;Future;Future Teacher;geographically distant;Goals;Grant;health disparity;Home;improved;Individual;innovation;Institution;interest;International;Intervention;Leadership;Measurable;Mentors;Modeling;Occupations;Outcome;Participant;Patient Self-Report;Population;Positioning Attribute;Postdoctoral Fellow;Preparation;Productivity;Program Development;programs;psychosocial;public trust;Publications;racial minority;racial population;Recording of previous events;Research;research faculty;Research Personnel;Resources;Scholars Program;Scholarship;Science;Scientific Societies;Scientist;senior faculty;Site Visit;skill acquisition;skills;social influence;Societies;STEM career;STEM field;success;Talents;tenure track;Training;Training Programs;undergraduate student;Underrepresented Populations;Universities;Woman

PROJECT_TITLE: ASCB's MOSAIC Program (AMP)


NIH_SPENDING_CATS: Bioengineering;Biotechnology

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: There is mounting evidence that proteins at the cell membrane, which allow cells to sense and respond to the external environment, are highly organized. The goal of the proposed studies is to investigate the nature of this organization, how it comes about, and how it affects the proteins’ functions, focusing on processes that regulate blood vessel formation and immune cell function. This will be achieved by developing innovative live-cell imaging and computational image and data analysis approaches to quantitatively probe molecules in their native cellular environment and dissect their complex behaviors and interrelationships.

PI_NAMEs: JAQAMAN, KHULOUD  (contact)

PROGRAM_OFFICER_NAME: PHILLIPS, ANDRE W

PROJECT_TERMS: Actins;Affect;analytical tool;Angiogenesis Promoter;Antigen-Presenting Cells;Behavior;Biological Models;Biophysical Process;Biosensor;blood vessel development;Blood Vessels;Cell membrane;Cell Physiology;Cell Surface Receptors;Cells;Complex;Data Analyses;Disease;Endothelial Cells;Environment;Exhibits;experimental study;Family;Focal Adhesions;Goals;Heterogeneity;Image;Image Analysis;imaging modality;Immune;immune function;In Vitro;innovation;Integral Membrane Protein;Integrins;interest;KDR gene;Knowledge;Ligand Binding;Ligands;Liquid substance;live cell imaging;mathematical analysis;Membrane;Microscopy;Molecular;Molecular Probes;Nature;novel;Pathway interactions;Phase;Physiology;Process;Proteins;receptor;Receptor Cell;Receptor Protein-Tyrosine Kinases;reconstitution;Regulation;Research;Resolution;Role;Signal Transduction;Signaling Protein;single molecule;spatiotemporal;Specificity;Statistical Data Interpretation;System;T-Lymphocyte;tool;ultra high resolution;Work

PROJECT_TITLE: Mechanisms and Functional Consequences of Signaling Protein Organization at Membranes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-D(55)R]


NIH_SPENDING_CATS: Genetics

ORG_CITY: SAN DIEGO

ORG_DEPT: BIOLOGY

ORG_NAME: SAN DIEGO STATE UNIVERSITY

PHR: PROJECT NARRATIVE Morphological plasticity is fundamental to bacterial fitness and survival in a variety of environmental and host- associated niches. Filamentation is an example of this plasticity, as bacteria can dramatically increase in length to survive a variety of insults, including predation, phagocytosis, and exposure to antimicrobial compounds. This proposal will characterize a novel, nutrient-based mechanism for induction of filamentation whereby an intracellular bacterium detects invasion of a host cell to initiate filamentation for spreading into neighboring cells.

PI_NAMEs: LUALLEN, ROBERT J (contact)

PROGRAM_OFFICER_NAME: BLATCH, SYDELLA ANNE

PROJECT_TERMS: Animals;antimicrobial;Bacteria;bacterial fitness;Bacterial Genes;Biological Models;Bordetella;Caenorhabditis elegans;Cell Shape;Cell Size;Cells;Dependence;detection of nutrient;Environment;Epithelial Cells;Exposure to;Filament;fitness;Genes;Genetic;Genetic Models;Glucose;Growth;innovation;intestinal epithelium;Invaded;Lead;Length;member;model organism;Morphology;Mutagenesis;novel;Nutrient;Pathway interactions;Phagocytosis;Phenotype;Play;Predatory Behavior;response;Role;SOS Response;Testing;Work

PROJECT_TITLE: Understanding the mechanisms of intracellular filamentation by bacteria

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-GGG-X(55)R]


NIH_SPENDING_CATS: Bioengineering

ORG_CITY: MOUNTAIN VIEW

ORG_NAME: SETI INSTITUTE

PHR: Project Narrative  The element iron plays an enormous role in biology, and we plan to study how iron contributes to catalysis (in hydrogenases), to pH and small molecule sensing (in NEET proteins), and to electron transport reactions (in rubredoxins). Using very bright x-ray beams from synchrotron radiation sources, we will study the vibrations of iron in the above systems, and this will provide structural information about how these proteins work. Information and insights gained from this project will help us better understand the biological chemistry of iron, so that we can learn from Nature to create a more efficient and healthier society and perhaps alleviate the damage from cancer and other diseases that occurs when some of these enzymes fail.

PI_NAMEs: CRAMER, STEPHEN P. (contact)

PROGRAM_OFFICER_NAME: SIMONOVIC, MILJAN

PROJECT_TITLE: Spectroscopy of Fe-S Cluster Proteins -- Information for Structure and Function

STUDY_SECTION: MSFA

STUDY_SECTION_NAME: Macromolecular Structure and Function A Study Section[MSFA]


ORG_CITY: SALT LAKE CITY

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Narrative We will analyze whole-genome and RNA sequence data in a unique collection of multigenerational Utah pedigrees to answer fundamental questions about the causes and consequences of germline mutation, somatic mutation, and DNA repair. We will correlate these with measured phenotypes. We will also develop analytic tools and apply them in large pedigrees to identify and characterize disease-causing genes.

PI_NAMEs: JORDE, LYNN  (contact)

PROGRAM_OFFICER_NAME: MASKERI, BAISHALI

PROJECT_TERMS: Adult;Age;Amyotrophic Lateral Sclerosis;analytical tool;Blood;Blood specimen;Chronic Childhood Arthritis;Collection;Data;de novo mutation;Detection;Disease;DNA;DNA Insertion Elements;DNA Repair;DNA Repair Gene;Event;Family;Funding;Generations;Genes;Genetic Diseases;genetic information;genetic pedigree;Genetic Variation;Genome;Germ Lines;Germ-Line Mutation;Human;Human Genetics;improved;In Vitro;in vivo;life span;Longitudinal Studies;Measurement;Measures;member;Methods;Mosaicism;Mutation;Participant;Pattern;Phenotype;Population Database;Premature Menopause;public repository;Resources;RNA Sequences;Sampling;Sequence Analysis;Somatic Mutation;System;Testing;Time;transcriptome sequencing;transmission process;Utah;Variant;Whole Blood;whole genome;Work

PROJECT_TITLE: Human Genetic Variation and Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-S(55)R]


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

PHR: Project Narrative Secure messaging (SM) via patient portals is an effective health IT platform that can enable patients and providers to reach shared understanding, an intermediate communication outcome, which has been linked to improved adherence, better disease control, and safer outcomes. For patients with communication barriers, advanced age or severe illness, SM also has potential to engage caregivers in facilitating patients’ ability to reach shared understanding with their healthcare providers. The goal of the research proposed in this career development award is to (a) understand the value and attributes of caregiver involvement in SM exchange between diverse T2D patients and their providers, and (b) apply this knowledge to develop a pilot portal intervention in the safety-net targeting diverse T2D patients (at high risk for hypoglycemia, a patient safety event) and their caregivers to promote shared understanding and safety.

PI_NAMEs: SEMERE, WAGAHTA  (contact)

PROGRAM_OFFICER_NAME: WILLIS, TAMARA

PROJECT_TITLE: Promoting Safety by Engaging Diverse Diabetes Patients and their Caregivers in Secure Messaging

STUDY_SECTION: HCRT

STUDY_SECTION_NAME: Healthcare Research Training [HCRT]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: NARRATIVE The advent of molecular imaging has prompted a paradigm shift in medical imaging as a whole, from its foundations in purely anatomical imaging towards techniques aimed at probing tissue phenotype and function. We have for many years exploited aberrant targets associated with cancer in order to better diagnose, stage and monitor this disease. In this R35, we plan to highlight three highly integrated areas within the context of our expertise and insights that will have a significant impact on cancer treatment outcomes.

PI_NAMEs: LEWIS, JASON S. (contact)

PROGRAM_OFFICER_NAME: WANG, YISONG

PROJECT_TERMS: Address;anatomic imaging;Area;Biology;Cancer Biology;cancer imaging;cancer therapy;Chemicals;Chemistry;Clinic;clinical translation;detector;Development;Diagnosis;Discipline;Disease;Engineering;Foundations;Genomics;Human;Image;imaging agent;Imaging technology;improved;in vivo imaging;insight;Label;Laboratories;Malignant Neoplasms;Measures;Medical Imaging;Methodology;Methods;Molecular;molecular imaging;Monitor;new therapeutic target;non-invasive imaging;novel;Organism;Pathway interactions;Pharmacology;Phenotype;pre-clinical;predicting response;programs;Radiochemistry;response;Techniques;theranostics;Time;Tissues;Translating;translational research program;Treatment outcome;tumor heterogeneity;Visualization;Work

PROJECT_TITLE: Annotating Cancer Biology through Non-Invasive Molecular Imaging


ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

PHR: PROJECT NARRATIVE – Overall The Duke Pepper Older Americans Independence Center (OAIC) will advance knowledge of reserve and resilience in older adults and develop and evaluate strategies to improve the ability of older adults to withstand or recover from health stressors. Aging is associated with increasing exposure and vulnerability to multiple stressors that threaten independence; so, research on resilience in older adults is essential to bolster independence. The Duke OAIC will train promising new investigators through a comprehensive multidisciplinary program and support pilot studies to lead to innovative larger grants investigating reserve and resilience in older adults.

PI_NAMEs: COLON-EMERIC, CATHLEEN S;SCHMADER, KENNETH E (contact)

PROGRAM_OFFICER_NAME: SERRA, MONICA CHRISTINE

PROJECT_TERMS: 2019-nCoV;Accelerometer;Achievement;Address;Adult;Adverse effects;Aging;American;Biological;Biometry;Caliber;Capsicum;career development;circulating microRNA;Clinical;Clinical Research;Collaborations;Communities;Counseling;dashboard;Data;data integration;Data Science;design;Development;education research;Educational Activities;Educational Curriculum;Educational workshop;Elderly;Electronic Health Record;Event;experience;extracellular vesicles;Feedback;Financial Support;forging;Foundations;Funding;Geriatrics;Goals;Grant;Growth;Health;health care disparity;health data;health determinants;Hip Fractures;improved;Inflammatory;innovation;insight;Institution;Interdisciplinary Study;Intervention;Knowledge;late life;Lead;Leadership;life span;Maintenance;Measurement;Measures;Mentors;Metabolic;Methodology;Methods;MicroRNAs;Modeling;Molecular;molecular marker;Molecular Profiling;Molecular Target;multidisciplinary;next generation;novel;older adult;Older Population;Operative Surgical Procedures;Outcome;Pathway interactions;peer support;Persons;Phenotype;Physical activity;Physical Function;Physiological;Pilot Projects;Positioning Attribute;Process;programs;promote resilience;psychosocial;Recovery;Research;research and development;Research Personnel;research study;Research Support;resilience;resilience research;Resources;response;restoration;Science;Scientific Advances and Accomplishments;Secure;sensor;stressor;success;synergism;Systems Analysis;Talents;Techniques;Testing;therapy development;Training;translational approach;Translational Research;Work;working group

PROJECT_TITLE: Duke Claude D. Pepper Older Americans Independence Center


NIH_SPENDING_CATS: Aging

PI_NAMEs: SCHMADER, KENNETH E (contact)

PROJECT_TERMS: Administrator;Aging;aging population;American;Anesthesiology;Area;Bioinformatics;Biometry;Capsicum;Centers for Population Health;Clinical;Clinical and Translational Science Awards;Clinical Research;Collaborations;Core Facility;data integration;Decision Making;Development;Education;education research;Ensure;Environment;Faculty;Fostering;Funding;Funding Opportunities;Future;Geriatrics;Goals;Grant;Health;Healthcare Systems;improved;Infrastructure;innovation;Institution;Interdisciplinary Study;interest;Leadership;Malignant Neoplasms;Measures;Medical center;Medicine;meetings;member;Molecular;Monitor;older adult;operation;Operative Surgical Procedures;Orthopedics;Performance;Persons;Physiology;Pilot Projects;Process;programs;Progress Reports;Research;Research Activity;Research Institute;Research Personnel;resilience;Resource Allocation;Resource Sharing;Resources;Scientist;Secure;Strategic Planning;Structure;success;Teacher Professional Development;Translating;Translational Research;United States National Institutes of Health;Universities;working group

PROJECT_TITLE: Leadership and Administrative Core (LAC)


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Brain Disorders;Genetics;Human Genome;Multiple Sclerosis;Neurodegenerative;Neurosciences

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: NARRATIVE Autoimmune tissue inflammation is dictated by a balance between proinflammatory effector T cells and tissue protective FoxP3+ regulatory T cells. The factors besides cytokines that regulate the balance between Tregs and Th17 are beginning to be elucidated. By developing a novel computational algorithm Compass, we have identified polyamine pathway as a major metabolic driver the dictates the balance between Treg and Th17 cells. The proposal will focus on understanding the role of polyamine metabolism, mitochondrial respiration, and demethylase Jmjd3/Kdm6b at a molecular level by analyzing changes in transcriptome, metabolome, and epigenome.

PI_NAMEs: KUCHROO, VIJAY K. (contact)

PROGRAM_OFFICER_NAME: GUERAU, MIREIA

PROJECT_TERMS: Address;Affect;Algorithms;Anabolism;Atlases;Autoimmune;Autoimmune Responses;autoreactivity;Binding;Binding Sites;Biochemical Pathway;Cell Count;Cell Physiology;Cells;Cellular Assay;Cellular biology;Cellular Metabolic Process;Central Nervous System;Chemicals;Chromatin;CNS autoimmunity;Co-Immunoprecipitations;Complex;Computational algorithm;Cues;cytokine;Cytokine Signaling;Data;Development;dimer;Distant;DNA Binding;effector T cell;Electron Transport;Elements;Environment;Enzymes;Epigenetic Process;epigenome;epigenomics;Equilibrium;Experimental Autoimmune Encephalomyelitis;FOXP3 gene;Generations;Genes;Genetic;Genome;Glycolysis;histone demethylase;histone modification;human disease;Hypoxia;Immune;in vivo;Inflammation;Inflammatory;inhibitor;Interleukin-10;Investigation;Mediating;Metabolic;metabolic profile;Metabolism;metabolome;Mitochondria;Modification;Molecular;Multiple Sclerosis;Mus;neuroinflammation;novel;Nuclear;Ornithine Decarboxylase;Outcome;Oxidative Phosphorylation;Oxygen;Oxygen Consumption;Pathogenicity;Pathway interactions;Phenotype;Play;Polyamines;Post-Translational Protein Processing;Process;programs;Proliferating;Proteins;Reaction;recruit;Regulatory T-Lymphocyte;Resolution;Respiration;risk variant;Role;Severities;Shapes;single-cell RNA sequencing;Spermidine/Spermine N1-Acetyltransferase;System;T cell differentiation;T cell infiltration;T-Cell Development;T-Lymphocyte;Techniques;Testing;Tissues;tool;transcription factor;transcriptome;transcriptome sequencing;transcriptomics

PROJECT_TITLE: Metabolic regulators of Treg/Th17 balance in CNS autoimmunity

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


NIH_SPENDING_CATS: Behavioral and Social Science;Breast Cancer;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Networking and Information Technology R&D (NITRD);Patient Safety;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: Oakland

ORG_NAME: KAISER FOUNDATION RESEARCH INSTITUTE

PHR: NARRATIVE Social support, a social determinant of health (SDoH), is a definitive predictor of breast cancer (BC) treatment and mortality outcomes and is critical to racial/ethnic disparities in breast cancer (BC) treatment and mortality outcomes. This study will develop and validate an Electronic Health Record Social Support Patient Risk Tool (EHR-SUPPORT) in 44,348 women diagnosed with BC from Kaiser Permanente Northern California. Developing this measure is central to identifying patients at risk of low social support and to enhancing social support-cancer research needed to improve clinical care and reduce BC disparities.

PI_NAMEs: KROENKE, CANDYCE H (contact)

PROGRAM_OFFICER_NAME: CHOU, WEN-YING

PROJECT_TERMS: Academy;Address;African American;analytical method;anti-cancer research;Area;Asian;Asian Women;Black race;Breast Cancer Patient;Breast Cancer Treatment;California;cancer care;cancer health disparity;Cancer Research Network;Caring;chemotherapy;Clinical;clinical care;clinically relevant;Code;cohort;Cohort Studies;Data;Data Collection;Development;Diagnosis;Documentation;Electronic Health Record;Emergency Situation;ethnic disparity;ethnic diversity;Ethnic Minority Women;Ethnic Origin;Ethnic Population;Funding;hazard;Health;health care settings;Healthcare Systems;high risk;Hispanic;hormone therapy;improved;improved outcome;Information Technology;Intervention;Language;Linear Regressions;Link;Literature;Logistic Regressions;Logistics;Malignant Breast Neoplasm;Marital Status;Measures;Medical;Medical Care Team;Medical Records;Medicine;mortality;Natural Language Processing;Newly Diagnosed;Not Hispanic or Latino;Operative Surgical Procedures;Outcome;Pacific Islander;Pathway interactions;patient response;Patient risk;Patient-Focused Outcomes;Patients;Perception;Pilot Projects;Population;Provider;Publishing;Questionnaires;Race;racial disparity;racial diversity;racial minority women;racial population;Recommendation;Research;Research Personnel;Resources;Risk;ROC Curve;Services;social;social computing;Social Conditions;social health determinants;Social Network;social relationships;social structure;Social support;Source;Structure;structured data;Text;theories;tool;treatment and outcome;Treatment outcome;unstructured data;White Women;Woman;women's diagnosis;Work

PROJECT_TITLE: An Electronic Health Record-Based Tool to Identify Newly Diagnosed Breast Cancer Patients at Risk of Low Social Support

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-K(56)]


NIH_SPENDING_CATS: Aging;Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Coronaviruses;Emerging Infectious Diseases;Genetics;Infectious Diseases

PI_NAMEs: KRAUS, VIRGINIA  (contact)

PROJECT_TERMS: 2019-nCoV;Affect;Aging;aging related;American;analytical tool;Apoptosis;Area;Autophagocytosis;Back;Basic Science;beta-Galactosidase;Biochemical;Biochemical Markers;Biological;biological age;Biological Models;Biological Process;Body System;Capsicum;career development;Cell Culture Techniques;Cell Proliferation;Cells;Clinical Research;cohort;Collaborations;Consultations;Coronavirus;COVID-19 pandemic;Data;Data Analytics;data integration;data management;design;Development;DNA Damage;education research;Elements;Ensure;Epigenetic Process;epigenomics;Evaluation;extracellular vesicles;Funding;genomic data;Genomics;Health;Human;human coronavirus;Immune;In Vitro;in vitro Model;Individual;Inflammation;Inflammatory;inflammatory marker;inhibitor;insight;Intervention;Investigator-Initiated Research;Knowledge;Leadership;life span;Link;Liquid substance;Longevity;longitudinal dataset;Measures;Mentors;Mentorship;Metabolic;Metabolic Marker;metabolomics;Methods;MicroRNAs;Mission;Molecular;Molecular Analysis;molecular array;molecular marker;Molecular Profiling;novel;Organ;Outcome;Output;Pathway Analysis;Pathway interactions;Patients;Persons;Phenotype;Physiological;Plasma;post SARS-CoV-2 infection;Primates;promote resilience;Proteomics;regenerative;Research;Research Personnel;Research Project Grants;resilience;Resistance;Resources;response;Review Literature;Sampling;SARS-CoV-2 antigen;senescence;Serology;Serology test;Serum;Services;stressor;System;Testing;theories;Tissue Extracts;Tissues;Training;Translations;Work;working group

PROJECT_TITLE: Research Core 1: Molecular Measures Core (RC1)


NIH_SPENDING_CATS: Aging;Nutrition

ORG_NAME: DANA-FARBER CANCER INST

PHR: PROJECT NARRATIVE: Tissue aging is associated with a remodeling of redox signaling processes, and we recently developed a technology to map the protein targets of these signals comprehensively for the first time. We will apply this technology to systematically map the signaling landscape of these modifications, and investigate the mechanisms that link these processes to aging and lifespan regulation.

PI_NAMEs: CHOUCHANI, EDWARD THOMAS (contact)

PROGRAM_OFFICER_NAME: FU, YI-PING

PROJECT_TERMS: Age;age related;age-related disease;aged;Aging;aging related disease;alpha ketoglutarate;Biochemical;Biological;biological age;Biological Process;Caenorhabditis elegans;Chronology;Complex;Cysteine;Data;Data Set;Dietary Intervention;dietary restriction;Disease;Evolution;extend lifespan;Genetic;healthspan;in vivo;Intervention;life span;Link;Liver;Longevity;Mammals;Maps;Mediating;Metabolic;Metabolism;Methods;Modeling;Modification;Molecular;Mus;old mice;oxidation;Oxidation-Reduction;Pathology;Peripheral;pharmacologic;Physiological;Physiology;Play;Post-Translational Protein Processing;Process;protein complex;Protein Family;protein function;Proteins;Proteome;Proteomics;Reactive Oxygen Species;Regulation;Role;sex;Signal Transduction;Site;Technology;Testing;Time;Tissues;Translations

PROJECT_TITLE: Defining the landscape and mechanisms of protein redox regulation during aging


NIH_SPENDING_CATS: Aging;Bioengineering;Clinical Research

PI_NAMEs: HALL, KATHERINE SHEPHERD (contact)

PROJECT_TERMS: Aging;American;Applications Grants;Area;Biological Markers;biomarker performance;Capsicum;Clinical Research;Cognitive;cognitive reserve;Communities;community engagement;Consultations;dashboard;Data;Data Collection;data dashboard;data integration;Data Science;Data Set;Data Sources;design;Development;Devices;Doctor of Philosophy;education research;Educational workshop;Elderly;Electronic Health Record;Ensure;Equipment;Exercise;experience;Funding;Future;Grant;Health;health data;Healthcare;Human Resources;improved;innovation;interactive visualization;International;Intervention;Investigation;life span;Manuscripts;Measurement;Measures;meetings;member;Mentors;Mission;Molecular;Monitor;multidisciplinary;Outcome;Patient Self-Report;Performance;Personal Satisfaction;Persons;Phase;Physical Performance;Physiological;Pilot Projects;population based;predictive modeling;Preparation;Protocols documentation;psychosocial;Publishing;Reproducibility;Research;Research Design;research faculty;Research Personnel;Research Training;resilience;resilience in aging;Resources;Science;Services;smart technologies;social;social health determinants;Standardization;standardize measure;symposium;synergism;Testing;therapy development;Training;translational pipeline;Translational Research;wearable device;web site;whole health;Work;working group

PROJECT_TITLE: Research Core 2: Health and Mobility Measures Core (RC2)


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Social Determinants of Health

PHR: This project will leverage and pivot UCSF’s significant expertise, experience, and capacity in community-engaged research, disparities research, program implementation experience with populations that are underserved and vulnerable, data science, and major chronic diseases to create a nationwide research coordinating center and technical assistance center to support a network of NIMHD funded P50 centers to reduce multiple chronic disease related disparities in underserved and vulnerable populations.

PI_NAMEs: CHARLEBOIS, EDWIN DUNCAN;GANSKY, STUART A (contact);RHOADS, KIM FELDER

PROGRAM_OFFICER_NAME: STINSON, NATHANIEL

PROJECT_TERMS: Acceleration;Affect;African American;Alaska Native;Asian;biomedical informatics;California;Chronic;Chronic Disease;Cities;Clinical Trials Data Monitoring Committees;Clinical Trials Design;Collaborations;Collection;Common Data Element;Communication;Communities;community advisory board;community engaged research;community engagement;Community Networks;Community of Practice;community partners;community partnership;comorbidity;Country;COVID-19;Data;data management;Data Science;data sharing;data standards;data warehouse;design;Development;disease disparity;Disparity;disparity reduction;Education;education research;Educational workshop;Evaluation;experience;flexibility;Funding;Geography;Goals;Health;Health Disparities Research;Health Sciences;Hispanic;Homelessness;human subject;implementation science;Individual;instrument;Integrated Health Care Systems;Intervention;Intervention Trial;Latino;meetings;member;Mentors;Methods;minority health;minority health disparity;Minority-Serving Institution;Monitor;National Institute on Minority Health and Health Disparities;Native Americans;operation;Pacific Islander;Persons;PhenX Toolkit;Population;Prevention;programs;Race;Records;Research;Research Design;Research Personnel;Resource Sharing;Resources;response;San Francisco;Secure;Sexual and Gender Minorities;Site;skill acquisition;skills;social health determinants;socioeconomics;Standardization;Statistical Data Interpretation;tool;Underserved Population;United States National Institutes of Health;Universities;Vulnerable Populations;web site;webinar;working group

PROJECT_TITLE: Research Coordinating Center to Reduce Disparities in Multiple Chronic Diseases (RCC RD-MCD)


NIH_SPENDING_CATS: Aging;Genetics;Human Genome;Prevention

ORG_CITY: Los Angeles

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: PROJECT NARRATIVE As we age, mutations accumulate inside our cells that limit energy production, contributing to various forms of age-related pathology, including muscle wasting and neurodegeneration. In this application, we propose to determine when these mutations arise, what happens to them as we grow older and whether they can be selectively removed from our cells. Together, these experiments will help us gain a deeper understanding of the aging process itself, guide the development of treatments that are aimed at treating age-related disease, and help us determine when these treatments should be administered.

PI_NAMEs: VERMULST, MARC  (contact)

PROJECT_TERMS: Acceleration;Address;Affect;Age;age acceleration;Age Months;age related;Age related pathologies;age-related disease;Aging;aging process;Alleles;Animals;Autophagocytosis;Biology;Brain;Cell Aging;Cells;Childhood;Clonal Expansion;combat;detection method;Development;Disease;DNA biosynthesis;DNA polymerase gamma;driving force;Enzymes;Event;experimental study;Genetic;Genome;Health;Heart;Human;Induced Mutation;Inherited;insight;Intestines;Life;life span;Liver;Malignant Neoplasms;Mammalian Cell;Mediating;Mitochondria;Mitochondrial DNA;mitochondrial DNA mutation;mitochondrial genome;Modeling;Molecular;Motion;mouse model;Mus;Muscular Atrophy;Mutagenesis;Mutation;Mutation Detection;Natural History;Nerve Degeneration;normal aging;novel;Pathogenicity;Pathology;Predisposition;Premature aging syndrome;prevent;Process;Production;Rejuvenation;Risk Factors;single cell sequencing;Skeletal Muscle;Societies;Somatic Cell;Testing;therapy development;Time;Tissues;tool

PROJECT_TITLE: Temporal control of mitochondrial mutagenesis

STUDY_SECTION: CMAD

STUDY_SECTION_NAME: Cellular Mechanisms in Aging and Development Study Section[CMAD]


NIH_SPENDING_CATS: Aging;Bioengineering;Clinical Research;Data Science;Networking and Information Technology R&D (NITRD)

PI_NAMEs: PIEPER, CARL F (contact)

PROJECT_TERMS: Address;American;analytical method;Award;Awareness;Bioinformatics;Biological;Biometry;Capsicum;Clinical;clinical care;Code;Collaborations;Consultations;Data;Data Analyses;Data Analytics;Data Collection;data integration;data management;Data Management Resources;Data Science;data standards;design;Detection;Development;education research;Educational Technics;Ensure;Event;experience;Faculty;Funding;Genetic;Goals;graduate student;Group Meetings;Health;high dimensionality;Individual;Information Dissemination;innovation;insight;Instruction;interest;Intervention;Investigation;Joints;Knowledge;longitudinal analysis;Measurement;Measures;Mediation;meetings;Mentors;metabolomics;Methodology;Methods;Modeling;Modification;Molecular;Monitor;multidimensional data;Online Systems;Outcome;Parents;Pathway interactions;Performance;personalized predictions;programs;Property;Proteomics;Protocols documentation;Psychometrics;Publishing;Recovery;Reproducibility;Research;Research Design;Research Personnel;resilience;Resources;Science;Secure;Security;senior faculty;Standardization;Statistical Data Interpretation;Statistical Methods;Structure;synergism;Techniques;Time;Training;Training Support;Translating;Update;Validity and Reliability;Work;working group

PROJECT_TITLE: Research Core 3: Analysis Core (RC3)


NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Duchenne/ Becker Muscular Dystrophy;Heart Disease;Muscular Dystrophy;Pediatric;Rare Diseases

ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

PHR: PROJECT NARRATIVE: The proposed research is relevant to public health because Duchenne muscular dystrophy (DMD) causes muscle wasting, heart disease, and ultimately death. In this application, we will test a novel mechanism through which cardiac fibroblasts produce FGF23 to promote cardiac myocyte remodeling and functional defects in DMD hearts. The proposed research is relevant to NHLBI’s mission to identify specific pathogenic mechanisms that promote cardiomyopathy for the development of targeted therapeutics to preserve heart function so that patients can live longer and more fulfilling lives.

PI_NAMEs: WELC, STEVEN S (contact)

PROGRAM_OFFICER_NAME: LI, HUIQING

PROJECT_TERMS: Acute;Affect;Attenuated;Binding;Calcineurin;Cardiac;Cardiac Myocytes;Cardiomyopathies;cardioprotection;Cardiovascular Diseases;Cell Culture Techniques;Cells;cellular targeting;Cessation of life;Cicatrix;Clinical;Coculture Techniques;Complex;Data;Defect;Development;Disease;Disease Progression;Duchenne cardiomyopathy;Duchenne muscular dystrophy;dystrophic cardiomyopathy;Dystrophin;Event;experimental study;Extracellular Domain;Extracellular Matrix;FGFR4 gene;fibroblast growth factor 23;fibroblast growth factor receptor 4;Fibroblast Growth Factor Receptors;Fibroblasts;Fibrosis;Functional impairment;gain of function;General Population;Genes;Genetic;genetic approach;Goals;Heart;Heart Diseases;heart function;heart preservation;Hormones;Hypertrophy;Image;Impairment;improved;Inflammation;Injury;innovation;inorganic phosphate;Investigation;Kidney;Kidney Diseases;Knock-in;Knowledge;Life Expectancy;Longevity;loss of function;mdx mouse;Mechanics;Mediating;Mission;Morbidity - disease rate;mortality;mouse model;Muscle;Muscle Cells;Muscular Atrophy;Mutation;Myocardium;Myopathy;National Heart, Lung, and Blood Institute;new therapeutic target;novel;nuclear factors of activated T-cells;Onset of illness;Outcome;paracrine;Pathogenicity;Pathologic;Pathology;Patients;Phospholipase;Production;Public Health;receptor;Research;Research Personnel;Respiratory Insufficiency;Signal Transduction;Skeletal Muscle;System;targeted treatment;Testing;Therapeutic;therapeutic target;transgene expression;Ventricular Dysfunction;Work

PROJECT_TITLE: Paracrine actions of fibroblasts promote pathologic cardiac myocyte remodeling in Duchenne muscular dystrophy

STUDY_SECTION: MPPA

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology A Study Section [MPPA]


ED_INST_TYPE: GRADUATE SCHOOLS

ORG_CITY: LOS ANGELES

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: The proposal seeks to provide those in the biomedical community with research tools and new knowledge allowing to create selective binders to biomolecules and conceptually new probes for modern and emerging imaging techniques. These developments will allow to better understand biologically-relevant processes and ultimately formulate multimodal therapeutics and diagnostic agents to combat diseases.

PI_NAMEs: SPOKOYNY, ALEXANDER MICHAEL (contact)

PROGRAM_OFFICER_NAME: SALVADOR MORALES, CAROLINA

PROJECT_TITLE: Inorganic Chemistry Tools for Bioconjugation, Recognition and Imaging


NIH_SPENDING_CATS: Behavioral and Social Science;Biotechnology;Clinical Research;Estrogen;Genetics;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Infectious Diseases;Prevention;Sexually Transmitted Infections;Social Determinants of Health;Women's Health Research

ORG_NAME: EMORY UNIVERSITY

PHR: Project Narrative Many transgender people have an increased risk of HIV acquisition compared to the general population, yet little is known about how the use of gender-affirming hormones may impact mucosal HIV transmission. In this proposal, we will examine the effects of biological sex and sex hormone treatment on rectal mucosal epithelial and immune cell transcriptomic diversity and function, and we will assess the impact of sex hormone treatment on rectal mucosal immune responses and HIV susceptibility. A better understanding of rectal HIV transmission among transgender people utilizing gender-affirming hormone therapy could contribute to the development of sex- and gender-specific biomedical HIV prevention interventions.

PI_NAMEs: GRIMSLEY ACKERLEY, CASSIE  (contact)

PROGRAM_OFFICER_NAME: DEY, BARNA

PROJECT_TERMS: Achievement;Address;AIDS prevention;Anal Sex;Androgens;Anti-Inflammatory Agents;Antigen-Presenting Cells;Attention;B-Cell Activation;B-Lymphocytes;Bioinformatics;Biological;Biological Assay;Biological Factors;Biological Response Modifiers;biological sex;Biology;Biology of HIV Transmission;Biometry;Biopsy;career;career development;Cell Physiology;Cell Proliferation;Cells;Chromosome Mapping;cis-female;cis-male;Clinic;clinical translation;Colon;CXCL10 gene;CXCR3 gene;cytokine;Data;Data Analyses;Development;Effectiveness;Environment;Epithelial Cells;epithelial repair;epithelial stem cell;Epithelium;Estrogen Therapy;Estrogens;Event;experience;experimental study;Exposure to;Feminization;Fortification;Foundations;Funding;Future;gastrointestinal epithelium;Gender;gender affirming hormone therapy;gender affirming hormones;gender minority;Gene Expression;Gene Expression Profile;Gene Expression Regulation;gene repression;General Population;Genes;Genetic;Genetic Transcription;Genomics;Goals;Gonadal Steroid Hormones;Gut Mucosa;HIV;HIV Infections;HIV Seronegativity;hormone therapy;Hormone use;Hormones;Human;Immune;immune activation;Immune response;Immunologic Factors;Immunologics;Immunology;improved;Individual;Inflammatory;Influentials;innovation;Interferon Type II;Interleukin-10;Interleukin-2;Interleukin-6;Knowledge;Left;Mediating;men who have sex with men;Mentors;Mentorship;Methodology;Modality;Modeling;Mucins;Mucosal Immune Responses;Mucositis;Mucous body substance;Mucous Membrane;multidisciplinary;Natural Killer Cells;Pathway interactions;Persons;Pilot Projects;Population;pre-exposure prophylaxis;Predisposition;Prevention Research;preventive intervention;Primates;programs;Public Health;receptor;rectal HIV transmission;rectal mucosa;Rectum;Research;research study;Research Training;Resolution;Resources;response;Risk;Science;sex;Sex Chromosomes;Sex Differences;Sexual and Gender Minorities;sexual minority group;single-cell RNA sequencing;Site;T-Lymphocyte;Techniques;Technology;Testosterone;therapeutic development;therapeutic target;Tissues;Training;transcriptome;transcriptomics;transgender;transgender men;transgender women;Translational Research;transmission process;United States National Institutes of Health;Universities;Up-Regulation;vaccine response;Vaccines;Virus Replication;women's treatment

PROJECT_TITLE: Sex, Gender, and HIV Transmission: Defining the Impact of Biological Sex and Sex Hormones on Epithelial and Immune Cell Transcriptomics and HIV Transmission in Human Rectal Tissues

STUDY_SECTION: AIDS

STUDY_SECTION_NAME: Acquired Immunodeficiency Syndrome Research Study Section[AIDS]


NIH_SPENDING_CATS: Aging;Cardiovascular;Clinical Research

PI_NAMEs: WHITSON, HEATHER E. (contact)

PROJECT_TERMS: Aging;American;Animal Model;Apolipoprotein E;Apoptotic;Area;Award;Biological Models;bone aging;bone healing;bone repair;Budgets;Caliber;Capsicum;Cardiac Surgery procedures;career;career development;Career Mobility;Cells;Cellular biology;Clinical;clinical investigation;Clinical Sciences;Collaborations;Communities;community engagement;Data;design;Development;Discipline;education research;Ensure;Environment;Equity;Ethnic Population;Experimental Models;Funding;Geriatrics;Health;Heart failure;Heart Transplantation;Human;improved;Individual;Information Dissemination;Institution;Interleukin-15;Intervention;late life;Leadership;left ventricular assist device;Measures;Mentors;Mentorship;Molecular;novel;older adult;Organ;Outcome;Oxidative Stress;Patients;Persons;Pharmacologic Substance;Physiological;Pilot Projects;podocyte;Population;Primates;Process;promote resilience;Publications;racial population;Request for Proposals;Research;Research Personnel;resilience;Resources;Role;Schools;Science;Signal Transduction;stressor;success;synergism;Testing;Tissues;Training;Translating;Translational Research;Translations;Universities;Variant;Work

PROJECT_TITLE: Pilot/Exploratory Studies Core (PESC)


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: GEORGIA INSTITUTE OF TECHNOLOGY

PHR: PROJECT NARRATIVE  This project analyzes the mechanoreception of and between two major proteins on the platelet surface. These molecules is crucial in the initiation of the adhesion and signaling cascade in the hemostatic and thrombotic processes; thus the proposed work helps provide insights to these bleeding and thrombotic disorders.

PI_NAMEs: ZHU, CHENG  (contact)

PROGRAM_OFFICER_NAME: QASBA, PANKAJ

PROJECT_TERMS: adhesion receptor;Adhesions;Affinity;Agonist;Antiplatelet Drugs;Arteries;Binding;Biochemical;Biomechanics;Blood Coagulation Disorders;Blood flow;Blood Platelets;Blood Vessels;Clinical;Cytoplasm;Cytoplasmic Tail;Data;design;Fibrinogen;filamin;Functional disorder;G13 Protein;Glycoprotein Ib;Grant;Hemorrhage;Hemostatic Agents;Hemostatic function;Impairment;in vivo;insight;Integrins;Knock-in Mouse;Knowledge;Ligand Binding;Ligands;mechanical signal;Mechanoreceptors;mechanotransduction;Mediating;Membrane;Molecular Conformation;Mutation;Participant;Pathology;Physiology;Platelet Activation;Platelet aggregation;Process;Proteins;Publishing;receptor;Regulation;Reporting;Role;side effect;Signal Induction;Signal Pathway;Signal Transduction;Surface;synergism;Talin;Testing;Therapeutic;Thrombosis;thrombotic;Thrombus;von Willebrand Factor;Work

PROJECT_TITLE: Mechanotransduction of platelet receptors GPIb and GPIIb-IIIa

STUDY_SECTION: ICI

STUDY_SECTION_NAME: Intercellular Interactions Study Section[ICI]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: COLON-EMERIC, CATHLEEN S (contact)

PROJECT_TERMS: Acceleration;Address;Adult;Aging;aging related;American;Award;biobehavior;Body System;Capsicum;career;Climate;Collaborations;Communities;comorbidity;Competence;Complex;constructivism;Department chair;design;Development;Discipline;Education;education research;Educational Curriculum;Educational workshop;Equitable healthcare;ethnic minority population;Ethnic Population;Evaluation;evidence base;experience;Faculty;Feedback;Foundations;Funding;Gerontology;Geroscience;Goals;health disparity;Health Services;Historically Black Colleges and Universities;implementation intervention;Individual;Institution;Intervention;K-Series Research Career Programs;Learning;Mediating;Mediator;medical schools;medical specialties;Mentors;North Carolina;older adult;outreach;peer support;Persons;physical model;Physiological;population health;Population Heterogeneity;Productivity;programs;psychologic;racial minority population;racial population;recruit;Reduce health disparities;Research;Research Personnel;Research Project Summaries;Research Training;resilience;Resources;Scholars Program;skills;social;success;theories;Training;translational pipeline;Translational Research;Underrepresented Populations;Universities;virtual;Work

PROJECT_TITLE: Research Education Component (REC)


NIH_SPENDING_CATS: Cachexia;Cancer;Colorectal Cancer;Digestive Diseases;Liver Disease;Osteoporosis

ORG_CITY: Aurora

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Musculoskeletal complications associated with the occurrence of cachexia afflict up to 80% of patients diagnosed with colorectal cancer, and equally impact the quality of life in cancer survivors. By using in vitro and in vivo experimental models, we will define new pathological mechanisms responsible for bone resorption and muscle wasting in a context of elevated liver-derived IGFBP1. This study will shed light on novel mechanisms of cachexia and identify IGFBP1 as a therapeutic target for the treatment of musculoskeletal deficits in colorectal cancer.

PI_NAMEs: BONETTO, ANDREA  (contact)

PROGRAM_OFFICER_NAME: LINDHURST, MARJORIE JEAN

PROJECT_TERMS: Affect;Animals;Antibodies;Atrophic;Automobile Driving;Binding;Binding Proteins;bone;bone loss;bone mass;Bone Resorption;Cachexia;Cancer Cachexia;cancer cell;Cancer Survivor;carcinogenesis;colon cancer patients;Colorectal Cancer;colorectal cancer prevention;Communication;Development;Diagnosis;Disease;Endocrine Glands;Event;Exhibits;Experimental Models;Family;Gene Expression;Genomics;Goals;Growth;Health;Hepatic;Hepatocyte;Homeostasis;Hormones;IGFBP1 gene;Implant;improved;In Vitro;in vivo;Integrins;knock-down;Knock-out;Knockout Mice;Liver;Malignant Neoplasms;MC38;Mediating;Metabolic;metastatic colorectal;Metastatic Neoplasm to the Liver;Morbidity - disease rate;mortality;Mus;Muscle;Muscle Fibers;muscle form;Muscle function;Muscular Atrophy;Musculoskeletal;Neoplasm Metastasis;new therapeutic target;novel;Organ;osteoclastogenesis;Osteoclasts;overexpression;Pathologic;Patients;Play;prevent;Quality of life;receptor;Recombinants;Recurrent disease;reduced muscle mass;Reporting;Research;Resolution;response;Role;Signal Transduction;single-cell RNA sequencing;Skeletal Muscle;skeletal preservation;Somatomedins;subcutaneous;Surface;Symptoms;therapeutic target;Tissues;Transplantation;tumor;tumor growth;tumor initiation;Tumor-Derived;Viral Vector;wasting;Wasting Syndrome

PROJECT_TITLE: IGFBP1 mediates a liver-bone-muscle axis in colorectal cancer cachexia

STUDY_SECTION: SMEP

STUDY_SECTION_NAME: Skeletal Muscle and Exercise Physiology Study Section[SMEP]


NIH_SPENDING_CATS: Neurosciences

ORG_DEPT: NEUROSURGERY

PHR: PROJECT NARRATIVE There is a need for well-trained neurosurgeons to perform basic science, translational, and clinical research focused on understanding and treating neurological diseases. This renewal application aims to support the development/ education of neurosurgical residents who wish to pursue careers as clinician-scientists. The research training and mentorship will afford trainees the foundation to become independent investigators who are equipped to understand and treat pathologies of the brain and spinal cord.

PI_NAMEs: MACK, WILLIAM J (contact)

PROGRAM_OFFICER_NAME: WEIGAND, LETITIA ALEXIS

PROJECT_TERMS: Address;Advisory Committees;Appointment;Award;Basic Science;Benchmarking;Brain Pathology;career;career development;Clinical;Clinical Pathways;Clinical Research;Data;Dedications;design;Development;Disease;Education;Education Projects;education research;Educational Activities;Educational Curriculum;Ethics;Evaluation;expectation;experience;Extramural Activities;Faculty;Feedback;Fellowship;field study;Fostering;Foundations;Functional disorder;Funding;Generations;Goals;Grant;improved;Individual;innovation;Institution;Instruction;interest;K-Series Research Career Programs;Leadership;Learning;Measures;Medical;meetings;member;Mentored Clinical Scientist Development Program;Mentors;Mentorship;Monitor;Nervous System Disorder;Neurosciences;Neurosurgeon;neurosurgery;Performance;Physicians;Positioning Attribute;Preparation;programs;Records;recruit;Research;research and development;Research Personnel;Research Proposals;Research Training;Residencies;Resources;Schedule;Scientific Advances and Accomplishments;Scientist;Secure;Series;Spinal Cord;Structure;success;Surveys;System;Time;Training;Training and Education;training opportunity;Training Programs;Translational Research;translational study;United States National Institutes of Health;Universities

PROJECT_TITLE: USC Neurosurgery Research and Education Training Program


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Cancer;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY

PHR: Narrative The overarching goal of the Data Science for Social Determinants (DSSD) pre- and post-doctoral training program is to develop future leaders in data science who are equipped to develop and analyze data to better leverage deep and rich survey as well as internet and other digitized data sources that can help us capture information on the social determinants of health. Such data can provide unique illumination into factors on where we live, work, and play which can be used to better understand and address health disparities across noncommunicable disease, infectious disease and injuries in the Kenyan context. However, the data are often unstructured and can have complex relationships with health outcomes, making the use of modern data science approaches critical. DSSD leverages strong investment across biomedical, public health, data science and artificial intelligence investment at both partners (NYU School of Medicine is 11th in the nation for NIH funding, NYU is home of the AI-now institute and Moi University has a strong NIH funding record) as well as a broader network of academic, industrial and non-governmental organizations (IBM, Deep Learning Indaba, DataKind, AI.Kenya and Aga Khan University Nairobi and Karachi), opening a wide pool of potential, strong trainees from both data science and health backgrounds. To develop capacity, priority will be given to Moi affiliates, Kenyan citizens and then others from anywhere in Africa while also prioritizing diversity. A complementary team of 23 mentors at NYU and Moi committed to training and career development will offer resources across social determinants, biomedical sciences, statistics, epidemiology, data management, analytics and ethics. First, the program will provide long-term development of a cohort of PhD, postdoctoral and Faculty fellow trainees who will benefit from interdisciplinary training that carefully layers a core set of competencies in data science across data management and wrangling, prediction and analytics and data communication and ethics, with didactic and experiential training in social determinants as well as best practices in responsible conduct of research, reproducibility and community-engaged, ethical data science at NYU. Second, the program will leverage international standard biostatistics and informatics faculty and programming at Moi with trainees equipped in advanced data science coursework at NYU, to expand the base of local expertise and capacity in data science by developing MSc and PhD data science tracks at the Institute for Biomedical Informatics and Biostatistics programs at Moi University within 5 years. Finally, continuing education opportunities and networking will occur through workshops bringing together experts in health and data science in Kenya and surrounding areas. Programs will be evaluated annually by our Internal Advisory Board and Training Advisory Committee. As social determinants can be cross-cutting rather than disease-specific, classroom and research opportunities across social determinants and their applicability to wide range of health application domains will be available at both project sites and curricula will be relevant to research and training efforts across the entire DSI-Africa consortium.

PI_NAMEs: CHUNARA, RUMI  (contact);HOGAN, JOSEPH W;MWANGI, ANN ;VEDANTHAN, RAJESH

PROGRAM_OFFICER_NAME: POVLICH, LAURA

PROJECT_TERMS: base;curriculum development;Data;Data Science;Data Sources;deep learning;design;Doctor of Philosophy;Faculty;Future;Goals;Health;Industry;Institution;Internet;Kenya;meetings;New York;Postdoctoral Fellow;social determinants;social health determinants;Surveys;Talents;Training;Training Programs;Universities

PROJECT_TITLE: NYU-Moi Data Science for Social Determinants Training Program

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-C(70)]


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Complementary and Integrative Health;Dietary Supplements;Microbiome;Natural Products;Nutrition

ORG_CITY: SANTA CRUZ

ORG_NAME: UNIVERSITY OF CALIFORNIA SANTA CRUZ

PHR: Public Health Relevance: The proposed program aims to develop new technologies that will allow advancements in the chemical and biological understanding of botanicals and natural products that are used for the improvement of health and the potential treatment to a wide range of disorders. As part of the development of these new technologies, we aim to provide a greater understanding of how multiple constituents in a botanical or natural products work in synergy to provide a biological activity. Overall, this program will help provide greater basic understanding of the molecules that are part of a $17 billion healthcare industry that currently has a number of outstanding questions.

PI_NAMEs: CECH, NADJA B;LININGTON, ROGER G;MACMILLAN, JOHN B (contact)

PROGRAM_OFFICER_NAME: STILL, PATRICK COLBY

PROJECT_TERMS: Address;Area;Back;Belief;Bioinformatics;Biological;Biological Assay;Biology;Botanicals;Cell Line;Cells;Chemicals;Clinical Trials;Communities;Complex;Complex Mixtures;Computer Models;Constitution;Cytology;Data;Data Analytics;data integration;Databases;Development;Disease;Disparate;Epithelial Cells;experience;Generations;gut microbiome;Health;Health Benefit;Healthcare Industry;improved;In Vitro;in vivo;Informatics;innovation;interest;Link;Macrophage;Maps;Medicinal Plants;Metabolic;Metabolism;metabolomics;Modeling;Modification;Molecular Target;Natural Products;Natural Products Chemistry;Neurons;new technology;novel;Online Systems;Outcome;Phenotype;Plant natural product;Process;programs;public health relevance;Reagent;receptor;Role;screening;Signal Pathway;Speed;success;synergism;Technology;technology platform;technology validation;Text;tool;web site;Work

PROJECT_TITLE: The Center for High Content Functional Annotation of Natural Products


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Opioid Misuse and Addiction;Opioids;Pediatric;Prevention;Social Determinants of Health;Substance Misuse

ORG_DEPT: PSYCHIATRY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE Various adverse and protective environments may affect child development. The Healthy Brain and Child Development National Consortium (HBCD-NC) will follow 7,500 mothers and their children from 24 locations across the U.S. from before birth to 10 years of age to better understand which harmful and protective environments exert the greatest impact on child development. This study will help to improve the health and development of children across the nation.

PI_NAMEs: BERRY, OBIANUJU ;SHUFFREY, LAUREN CHRISTINE;THOMASON, MORIAH E (contact)

PROGRAM_OFFICER_NAME: PRABHAKAR, JANANI

PROJECT_TERMS: 10 year old;Address;Adverse event;Affect;Alcohols;Behavioral;Biological;Birth;Brain;Caregivers;caregiving;Child;child bearing;Child Development;cohort;Communities;Conceptions;COVID-19;critical period;Data;Data Collection;Data Coordinating Center;data integrity;Data Set;data standards;design;Development;DNA;early experience;early life exposure;Electroencephalography;Enrollment;Environment;Environmental Exposure;Environmental Hazards;Epigenetic Process;Ethics;Ethnic Origin;Event;experience;Exposure to;Feedback;General Population;Genes;Goals;hazard;Health;Helping to End Addiction Long-term;Human;improved;Infant;Infection;innovation;insight;Life;Link;Location;Magnetic Resonance Imaging;Malnutrition;maltreatment;Marijuana;Maternal Health;maternal stress;Measures;Methods;Modality;Monitor;Mothers;multidimensional data;multimodality;neurodevelopment;neuroimaging;Newborn Infant;novel;Opiate Addiction;Opioid;opioid misuse;Outcome;Participant;Persons;Physiological;Population;postnatal;Pregnancy;pregnant;Pregnant Women;prenatal;prenatal exposure;Process;protective factors;Protocols documentation;psychologic;Psychopathology;Public Health;Public Policy;Race;recruit;remote assessment;Research;Research Design;Research Personnel;Sampling;Second Pregnancy Trimester;Severities;Shapes;Site;socioeconomics;sound;Speed;stem;Stress;Structural Racism;substance use;Time;Time Study;Tobacco;tool;Toxicant exposure;Training;United States;United States National Institutes of Health;Woman;Work

PROJECT_TITLE: 8/24 The Healthy Brain and Child Development National Consortium

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-D(51)R]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Antimicrobial Resistance;Clinical Research;Clinical Trials and Supportive Activities;Infectious Diseases;Malaria;Microbiome;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Rare Diseases;Vector-Borne Diseases;Women's Health Research

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE  In Africa, malaria in pregnancy contributes to approximately 20% of low birthweight infants and as such, the World Health Organization recommends a malaria chemoprevention strategy in which pregnant women receive repeated doses of sulfadoxine-pyrimethamine (SP) throughout their pregnancy. However, recent evidence suggests that SP, an antimalarial with known antibiotic and anti-inflammatory properties, may be improving LBW through mechanisms independent of its antimalarial activity. Thus, the goal of the proposed research is to improve our understanding of these non-malarial mechanisms in order to inform more optimal chemoprevention drug regimens that can target both the malarial and non-malarial causes of adverse birth outcomes in Africa.

PI_NAMEs: ROH, MICHELLE  (contact)

PROGRAM_OFFICER_NAME: ESBER, ALLAHNA LAUREN

PROJECT_TERMS: adverse birth outcomes;Affect;Africa;Anti-Inflammatory Agents;Anti-malarials;Antibiotics;arm;Automobile Driving;Birth;Birth Weight;career;Characteristics;Chemoprevention;Clinical Trials;Communicable Diseases;Conduct Clinical Trials;Data;Dose;Epidemiologist;Epidemiology;Falciparum Malaria;Goals;gut microbiome;Health Policy;Heterogeneity;improved;Individual;Infant Mortality;Inflammation;Intervention;intervention effect;Investigation;Low Birth Weight Infant;Malaria;Malaria prevention;Maternal and Child Health;Mediating;Mediation;Mediator;Mentorship;Meta-Analysis;Methods;Modeling;novel;Outcome;Parasite resistance;personalized approach;Pharmaceutical Preparations;Plasmodium falciparum;policy recommendation;Population;Positioning Attribute;Pregnancy;Pregnant Women;prevent;Prevention strategy;Preventive treatment;Property;Pyrimethamine;Randomized, Controlled Trials;Recommendation;Regimen;Reproductive Tract Infections;Research;Research Personnel;Risk;Safety;Sexual Transmission;Site;Statistical Methods;statistics;Sulfadoxine;Sulfadoxine-pyrimethamine resistance;Testing;Training;Translating;vaginal microbiome;Woman;World Health Organization

PROJECT_TITLE: Examining the mechanisms and optimization of malaria chemoprevention strategies to improve birth outcomes in Africa

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Obstetrics and Maternal-Fetal Biology Study Section[CHHD-B]


NIH_SPENDING_CATS: Chronic Pain;Clinical Research;Genetics;Neurodegenerative;Neurosciences;Pain Research;Pediatric;Peripheral Neuropathy

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: This is an application to renew current R01 award that has funded our research on small-fiber neuropathy (SFN), which is increasingly linked to fibromyalgia and mysterious multi-symptom illnesses that include unexplained widespread pain, intolerance of exertion and gastrointestinal discomfort. We now propose to revise and optimize the tools we developed for SFN diagnosis for use by doctors and patients around the world and to work with the U.S. Food and Drug Administration to get their Qualification recommendations on how to improve the skin biopsies used globally to confirm SFN diagnoses. We will also collaborate with a leading neuropathy geneticist to sequence the genes of SFN patients we select with our tools that have genetic mutations likely to contribute fundamental knowledge about SFN.

PI_NAMEs: OAKLANDER, ANNE LOUISE  (contact)

PROGRAM_OFFICER_NAME: GREENWELL, THOMAS

PROJECT_TERMS: 21 year old;Address;Adult;Age;Age Reporting;aged;Analgesics;Award;Biological Markers;Biopsy;Blood Tests;Candidate Disease Gene;Cellular Phone;chemotherapy;Child;Childhood;chronic pain;chronic widespread pain;Clinical;Clinical Trials;cohort;Collaborations;Communities;Complement;Computerized Medical Record;Data;density;Development;Diabetes Mellitus;Diagnosis;diagnostic accuracy;diagnostic tool;Disease;Distress;DNA Sequence Alteration;early onset;effective therapy;Epidemiology;Epigenetic Process;ethnic diversity;Etiology;Evaluation;evidence base;Examinations and Diagnoses;Exertion;Family;Family member;Fiber;Fibromyalgia;foot;Funding;Future;gastrointestinal;Genes;Genetic;Genetic Risk;Genome;genome wide screen;genome-wide;Genomics;Genotype;Goals;health disparity;healthy volunteer;Hereditary Sensory and Autonomic Neuropathies;Immune;Immunoglobulins;improved;Individual;Internet;Knowledge;lectures;Leg;Letters;Life;Link;Manuscripts;Maps;Measurement;Measures;Medical;meetings;Modeling;Monitor;Names;Natural History;Nerve Endings;Nerve Fibers;neurogenetics;neuropathology;Neuropathy;older adult;Outcome;Pain;Pain Measurement;Pain Research;painful neuropathy;Participant;Pathogenicity;Pathway interactions;Patient Care;Patient Recruitments;patient registry;Patient Selection;Patients;Peripheral Nerves;Peripheral Nervous System Diseases;Persons;Pharmacodynamics;Phenotype;Physicians;Polyneuropathy;Population;Predictive Value;Prevalence;Probability;Procedures;Productivity;programs;Public Health;Publishing;PubMed;Qualifying;Recommendation;recruit;Registries;relational database;Reporting;Research;Research Personnel;research study;response;Risk;risk variant;Safety;Sampling;Schools;Secure;Site;skin biopsy;Source;Specificity;Standardization;Surveys;Symptoms;Testing;tool;Toxicant exposure;treatment effect;United States Food and Drug Administration;United States National Institutes of Health;Untranslated RNA;Variant;Visit;web site;whole genome;Withdrawal;Work;young adult;Youth

PROJECT_TITLE: Evaluation of Small-Fiber Polyneuropathy in Youth

STUDY_SECTION: SPS

STUDY_SECTION_NAME: Somatosensory and Pain Systems Study Section[SPS]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases;Rare Diseases

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Filoviruses such as Ebola virus and Marburg virus are among the most lethal viral pathogens, but our understanding of their biology is incomplete. Our studies will clarify how expression of filoviral proteins is regulated and how these viruses evade antiviral responses of the host, thereby providing insight into what makes these viruses such deadly pathogens..

PI_NAMEs: BASLER, CHRISTOPHER F (contact)

PROGRAM_OFFICER_NAME: DUPUY, LESLEY CONRAD

PROJECT_TERMS: 3' Untranslated Regions;5' Untranslated Regions;Address;Adenosine;adenosine deaminase;Africa;Angola;Anti-viral Response;Biological Assay;Biological Models;Biology;Case Fatality Rates;Cell Culture Techniques;Cells;Cessation of life;Code;Containment;Data;Deamination;Detection;Disease;Disease Outbreaks;Double-Stranded RNA;dsRNA adenosine deaminase;Ebola virus;EIF-2alpha;Elements;emerging pathogen;Enzyme Induction;experimental study;Family;Fatality rate;Filoviridae Infections;Filovirus;follow-up;Gene Expression;Genes;Genetic Transcription;Genome;Growth;Guanosine;Health;Homeostasis;Hot Spot;Hour;Human;Immune Evasion;Immune response;Immune signaling;Immunologic Stimulation;In Vitro;in vivo;Infection;Innate Immune Response;Inosine;insight;interest;Interferon Activation;Interferons;Knock-out;Knockout Mice;Knowledge;Laboratories;Life Cycle Stages;Marburgvirus;Messenger RNA;MicroRNAs;Modeling;Molecular Biology;mRNA Translation;Mus;mutant;Mutation;Natural Immunity;Nucleoproteins;Open Reading Frames;pathogen;Pathogenesis;pathogenic virus;Pattern recognition receptor;Peptide Initiation Factors;Periodicals;Phosphorylation;Phosphotransferases;Protein Isoforms;Proteins;Public Health;Recombinants;Regulation;Regulatory Element;Reporting;Research;response;reverse genetics;RNA;RNA Viruses;Role;sensor;Site;Testing;Transfection;Translating;Translation Initiation;Translational Repression;Translations;Untranslated Regions;Viral;viral fitness;Viral Genes;Viral Genome;Viral Physiology;Virus;Virus Replication;Wild Type Mouse;Work;Zoonoses

PROJECT_TITLE: Intersection Between Viral Translation and Innate Immunity in the Context of Filovirus Infection

STUDY_SECTION: VIRA

STUDY_SECTION_NAME: Virology - A Study Section[VIRA]


PHR: Project Narrative These studies will address the unanswered fundamental question as to how androgen receptor (AR)-expressing cells recognize and respond to different doses of physiological/synthetic androgens. They will also formally test the “coregulator hypothesis” by exploring the relationship between hormone-induced changes in AR structure, differential recruitment of functionally distinct coregulators, and biological response. The insights from this work will be informative with respect to the pharmacology of existing AR-modulators and will direct approaches to develop the next generation of modulators for use in the treatment of prostate cancer (PCa) and other androgenopathies.

PI_NAMEs: MCDONNELL, DONALD P (contact)

PROGRAM_OFFICER_NAME: KAI, MIHOKO

PROJECT_TERMS: Affinity;Androgen Analogues;Androgen Receptor;Androgens;Andrology;Anemia;Architecture;associated symptom;Binding;Biochemical;Biological;Biological Models;Biology;Biosensor;bone;Cachexia;cancer therapy;Castration;Cell Cycle Proteins;Cell Proliferation;Cells;Chemicals;Chromatin;Climacteric;Complex;Cryoelectron Microscopy;Crystallography;Data;Development;dimer;Dimerization;Dose;E2F transcription factors;Exhibits;FOXM1 gene;FRAP1 gene;Gene Expression;Genetic;Global Change;Hormones;Hypogonadism;In Vitro;in vivo;insight;Ligand Binding;Ligands;Liver;Malignant Breast Neoplasm;Malignant neoplasm of prostate;Menopause;Metabolic;Molecular;monomer;mouse model;mRNA Translation;Muscle;next generation;non-genomic;Nuclear Receptors;Osteoporosis;Output;Ovarian;Pathologic;Pathway interactions;Pharmacology;Phenocopy;Phenotype;Physiological;preference;Process;programs;Prostate;Prostate Cancer therapy;Protein-Protein Interaction Map;receptor;Receptor-Interacting Protein;recruit;response;RNA Helicase;RNA-Binding Proteins;Role;sarcopenia;small molecule;Specificity;Stimulation of Cell Proliferation;Structure;Surface;Syndrome;Testing;Tissues;tool;transcription factor;tumor growth;Work

PROJECT_TITLE: Elucidation of the mechanisms by which cells recognize and respond to different levels of androgens

STUDY_SECTION: CSME

STUDY_SECTION_NAME: Cell Signaling and Molecular Endocrinology Study Section[CSME]


FUNDING_MECHANISM: SBIR-STTR RPGS

ORG_NAME: IT BIO, LLC

PHR: Narrative This proposal will pursue an HIV functional cure by developing a new generation of anti-HIV CD4 CARs that are resistant to exhaustion, enhanced for reactivation for improved immune surveillance and rendered infection-proof to maintain the pool of activated CD4 CAR-T cells without depletion. Testing will be conducted in non-human primates (monkeys) for the closest to human validation that is available.

PI_NAMEs: JUNGHANS, RICHARD P (contact)

PROGRAM_OFFICER_NAME: SANDERS, BRIGITTE E

PROJECT_TERMS: Address;Affect;Antibodies;Antigens;Antisense Technology;Area;B-Lymphocytes;base;Boston;cancer cell;CCR5 gene;CD28 gene;CD4 Antigens;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Physiology;Cell Therapy;Cells;checkpoint receptors;chimeric antigen receptor;chimeric antigen receptor T cells;Chronic;chronic infection;Clinical;Clinical Trials;Collaborations;Contract Services;cytokine;cytotoxic;Cytotoxic T-Lymphocytes;design;Down-Regulation;effector T cell;Engineering;Ensure;env Gene Products;Environment;exhaust;exhaustion;experimental study;Failure;Fee-for-Service Plans;Generations;Goals;HIV;HIV drug resistance;HIV Envelope Protein gp120;HIV Infections;HIV therapy;HIV-1;Human;Immune;Immunity;Immunologic Surveillance;improved;In Vitro;in vitro Assay;in vivo;in vivo evaluation;Infection;Inflammatory;Infusion procedures;Interferon Type II;Interleukin-2;Intervention;Investigation;knock-down;Knock-out;Laboratories;Ligands;Malignant Neoplasms;Mediating;Methods;Modeling;Molecular;Monkeys;neoplastic cell;nonhuman primate;novel;Patients;PD-1 blockade;Phase;pre-clinical;Preclinical Testing;preservation;Prevention;Primates;Process;Production;programmed cell death protein 1;rational design;receptor;receptor expression;Research;Resistance;response;Rest;RNA Interference;Side;Signal Transduction;Small Business Innovation Research Grant;small hairpin RNA;Structure;success;Surveys;T-Lymphocyte;Tars;Techniques;Technology;Testing;Text;Therapeutic;Therapeutic Agents;Universities;Up-Regulation;Validation;vector;Viral;Viral Proteins;Virus Latency;Virus Replication;Work;YY1 Transcription Factor

PROJECT_TITLE: Advanced generation infection-proof anti-HIV CAR-T with YY1 RNAi to block T cell exhaustion in NHP model