NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Diabetes;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: CHAPEL HILL

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: Narrative Diabetes mellitus is a metabolic disorder affecting about 8.8% of the world’s adult population, and these patients frequently suffer with skin and soft tissue infections, usually caused by Staphylococcus aureus. We find that S. aureus are more difficult to kill with antibiotics in diabetic mice and resistance evolves more rapidly. Here we will determine how diabetes contributes to antibiotic tolerance and resistance in S. aureus during infection.

PI_NAMEs: CONLON, BRIAN PATRICK (contact);THURLOW, LANCE R.

PROGRAM_OFFICER_NAME: HUNTLEY, CLAYTON C

PROJECT_TERMS: Acetic Acids;Acids;Address;Adult;Affect;Antibiotic Resistance;Antibiotic susceptibility;Antibiotic Therapy;antibiotic tolerance;Antibiotics;assault;Automobile Driving;Bacteremia;Bacterial Antibiotic Resistance;bactericide;Bioinformatics;Blood Glucose;Carbon;Cells;Chronic;chronic infection;Clinical Data;Clinical Research;Complication;Consumption;Data;Defect;Development;Diabetes Mellitus;diabetic;Diabetic mouse;diabetic patient;DNA Damage;Environment;Evolution;experimental study;fitness;Frequencies;Genetic;Glucose;Glycolysis;Goals;Growth;Immune;Immune response;Immune system;Immunosuppression;In Vitro;in vivo;Individual;Infection;Infectious Skin Diseases;Inpatients;Lactic acid;Metabolic Diseases;Metabolism;methicillin resistant Staphylococcus aureus;Microbial Biofilms;Modeling;mortality;multidisciplinary;Mus;Mutagenesis;Mutation;Nutrient;Organism;Osteomyelitis;pathogen;Patients;Phagocytes;Phenocopy;Phenotype;Population;Positioning Attribute;Predisposition;pressure;prevent;Production;Proliferating;Relapse;Research Personnel;Resistance;resistant strain;Respiratory Burst;Role;Sepsis;Severities;Sirolimus;Soft Tissue Infections;Source;Staphylococcus aureus;Staphylococcus aureus infection;Time;Treatment Failure;Treatment outcome;Vancomycin;Vancomycin Resistance;Virulent

PROJECT_TITLE: Diabetes and Antibiotic Treatment Failure


ADMINISTERING_IC: AR

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Dietary Supplements;Eye Disease and Disorders of Vision;Nutrition

ORG_CITY: BIRMINGHAM

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOCHEMISTRY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: The correct cellular concentration of the bioactive vitamin A derivative, all-trans-retinoic acid (RA) is critical for optimal performance of adult organs and tissues. The enzymes called retinol dehydrogenases are important because they determine the rate of RA biosynthesis, but not all retinol dehydrogenases have yet been identified. The proposed studies will show whether the candidate enzymes, retinol dehydrogenase 2 and retinol dehydrogenase-similar, contribute to RA biosynthesis and homeostasis in mammals in vivo.

PI_NAMEs: KEDISHVILI, NATALIA Y (contact)

PROGRAM_OFFICER_NAME: BELKIN, ALEXEY

PROJECT_TERMS: Acceleration;Adult;All-Trans-Retinol;Anabolism;Antibodies;Area;Beta Carotene;Binding;Cell Nucleus;cell type;Cells;circadian pacemaker;Complex;Cues;Custom;Cytoplasm;Darkness;Data;Development;Disease;Embryo;embryo tissue;Embryonic Development;Enzymes;Exhibits;Eyelid structure;Funding;Future;Gambling;Genes;gland development;Goals;Growth;Hair;Hair follicle structure;Health;Homeostasis;improved;In Vitro;in vivo;infancy;Knock-out;knockout gene;Knockout Mice;Knowledge;Laboratories;Light;Maintenance;malformation;Mammals;meibomian gland;meibomian gland dysfunction;Metabolism;Molecular;mouse model;Mus;Natural regeneration;novel;novel strategies;Nuclear;Organ;oxidation;Oxidoreductase;Pathway interactions;Pattern;Performance;Periodicity;Peripheral;Phase;Phenotype;Physiological;Physiological Processes;Production;Proteins;Publishing;Recycling;Regulation;Reporting;Research;Research Personnel;response;Retinaldehyde;Retinoids;Retinol dehydrogenase;Role;RXR;Signal Transduction;Skin;spatiotemporal;Statistical Data Interpretation;Sterols;Supplementation;Testing;Texas;Therapeutic Intervention;therapeutically effective;Time;Tissues;transcription factor;Tretinoin;Vitamin A;Woman

PROJECT_TITLE: Short-Chain Dehydrogenases in Retinol/Sterol Metabolism


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Clinical Research;Digestive Diseases;Food Allergies;Genetics;Human Genome

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: Project Narrative: The T helper lymphocyte type 2 (Th2) is a type of white blood cell that is capable of producing Th2 cytokines and that supports accumulation of another type of white blood cell, eosinophils. Eosinophilic esophagitis is a type of food allergy in which eosinophils build up in the tissue of the esophagus and cause inflammation and gastrointestinal symptoms. We found that certain human gastrointestinal bacteria metabolites (short-chain fatty acids) could enhance the Th2 cytokine production by Th2 lymphocytes, potentially causing EoE, and our proposed studies are expected to provide a detailed understanding of the regulatory role of short-chain fatty acids to Th2 cytokine production by Th2 lymphocytes in the Th2-inflamed tissue.

PI_NAMEs: ROTHENBERG, MARC E. (contact)

PROGRAM_OFFICER_NAME: MINNICOZZI, MICHAEL

PROJECT_TERMS: Acetylation;Agonist;Allergic;Allergic Disease;Allergic inflammation;Asthma;ATAC-seq;Binding;Biopsy;Blood;Butyrates;CD3 Antigens;Cell Line;Cells;Characteristics;ChIP-seq;Chromatin;Chromatin Structure;Chronic;Clinical;clinical care;cohort;cytokine;Data;Diet;Dietary Fiber;Disease;Enhancers;eosinophil;Eosinophilic Esophagitis;Epigenetic Process;Esophageal mucous membrane;Esophageal Tissue;Esophagus;Exhibits;FFAR3 gene;Food;Food Hypersensitivity;G-Protein-Coupled Receptors;gastrointestinal;gastrointestinal bacteria;gastrointestinal symptom;GATA3 gene;Gene Chips;Gene Expression;Genes;Genetic Transcription;genetic variant;genome-wide;Genomic DNA;Grant;Helper-Inducer T-Lymphocyte;Histones;Human;Human Cell Line;human tissue;IL5 gene;Immune;Immune response;Immunity;immunoregulation;improved;in vivo;Inflammation;Inflammatory;innovation;interest;Interleukin-13;Interleukin-4;Interleukin-5;knockout gene;Knowledge;Leukocytes;Ligands;Ligation;Lymphocyte;Lysine;Measures;Mediating;Messenger RNA;microbiome;microbiota;Modeling;Molecular;Mouse Cell Line;mouse model;Mus;novel;overexpression;Pathogenesis;Pathogenicity;Patients;Population;Production;Proteins;receptor;Regulation;Regulatory Element;Resolution;response;Rodent;Role;selective expression;single-cell RNA sequencing;Source;T-Cell Receptor;T-Lymphocyte;Testing;Therapeutic;therapeutic target;Tissues;Transcript;transcription factor;Volatile Fatty Acids

PROJECT_TITLE: Roles of FFAR 3-SCFA axis in Th2 cytokine production by tissuelymphocytes in EoE

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IMM-T(57)]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases;Orphan Drug;Rare Diseases;Tuberculosis

ORG_CITY: NEW YORK

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: Project Narrative: Pyrazinamide is an antibiotic used to treat tuberculosis, an infectious disease caused by the bacterium Mycobacterium tuberculosis, that kills more than 1 million persons every year worldwide. The bactericidal activity of pyrazinamide in vitro is poor which prevents the full understanding of its mode of action and diminishes our capacity to fight against pyrazinamide-resistant tuberculosis. Here, we show that pyrazinamide is highly active against M. tuberculosis when grown in a condition that recapitulates the infection settings and we will use this in vitro model to elucidate the mode of action of pyrazinamide to help the fight against pyrazinamide-resistant tuberculosis.

PI_NAMEs: GOUZY, ALEXANDRE  (contact)

PROGRAM_OFFICER_NAME: LAUGHON, BARBARA E

PROJECT_TERMS: Affect;Alveolar Macrophages;Animal Model;Animals;Antibiotics;antimicrobial;Antitubercular Agents;Bacteria;bactericide;Carbon;Cause of Death;Citric Acid Cycle;Coenzyme A;Coenzymes;Communicable Diseases;CRISPR interference;Culture Media;Cytochrome c Reductase;Cytochromes;Drug resistance in tuberculosis;Drug usage;Electron Transport;Environment;Enzymes;Etiology;fighting;Gene Deletion;Gene Expression;Genes;Genetic Determinism;Genetic Screening;Genetic study;Genus Hippocampus;Glycolysis;Goals;Growth;Human;Immune;improved;In Vitro;in vitro activity;in vitro Model;Infection;inhibitor;knock-down;Knock-out;Knowledge;Link;Lipids;Macrophage;Measures;Membrane Potentials;Metabolic Pathway;Metabolism;metabolome;metabolomics;Minimum Inhibitory Concentration measurement;Modeling;mutant;Mycobacterium tuberculosis;NADH;Nutrient;Oleic Acids;Oxidases;oxidation;Oxygen;Oxygen Consumption;pathogen;pathogenic bacteria;Pathway interactions;Patients;Persons;Phagolysosome;Pharmaceutical Preparations;Predisposition;prevent;Process;Proton-Motive Force;Protons;Pyrazinamide;Pyrazinamide resistance;pyrazinoic acid;Reporting;Resistance;resistance frequency;resistant strain;Respiration;Respiratory Chain;Supplementation;synergism;Technology;Testing;Tuberculosis;tuberculosis drugs;tuberculosis treatment

PROJECT_TITLE: Determination of the mode of action of the antibiotic pyrazinamide

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DDR-C(01)]


ADMINISTERING_IC: HL

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Genetics;Heart Disease

ORG_CITY: BLACKSBURG

ORG_DEPT: MISCELLANEOUS

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

ORG_STATE: VA

PHR: PROJECT NARRATIVE The heart constantly requires energy to work. Mitochondria, which are renowned as being “the powerhouse of the cell”, supply continuous energy to the cardiac cells. Mitochondria malfunction is closely linked to development defects and dysfunction in the heart. This application seeks to advance our understanding of metabolic reprogramming of the heart through mitochondrial signaling pathways during postnatal development and pathological development. Specifically, this proposal will utilize a genetic model and state-of-the-art multisystems approach to determine the role of the novel muscle-specific mitochondrial regulator Perm1 in mitochondrial biogenesis and energetics in the healthy and diseased hearts.

PI_NAMEs: DRAKOS, STAVROS GEORGE;WARREN, JUNKO SHIBAYAMA (contact)

PROGRAM_OFFICER_NAME: WONG, RENEE P

PROJECT_TERMS: Ablation;Acceleration;Adult;Anabolism;Animal Genetics;Animal Model;Bioenergetics;Biogenesis;Biological Assay;Cardiac;Cardiac Myocytes;Cell Nucleus;Cells;chromatin immunoprecipitation;Citric Acid Cycle;cofactor;Complex;Congestive Heart Failure;Crista ampullaris;Data;Defect;density;Development;Down-Regulation;EFRAC;energy balance;Epigenetic Process;ERR1 protein;Exercise;Exhibits;Fatigue;Feedback;functional adaptation;Functional disorder;Gene Delivery;Gene Expression;Genes;Genetic Models;Genetic Transcription;Global Change;Heart;Heart Diseases;Heart failure;heart function;heart metabolism;Heterozygote;histone methyltransferase;Human;human induced pluripotent stem cells;Impairment;induced pluripotent stem cell derived cardiomyocytes;interdisciplinary approach;knock-down;Knock-out;Knowledge;Link;Luciferases;Maintenance;Metabolic;Mitochondria;Mitochondrial Myopathies;Mus;Muscle;Muscular Atrophy;Myocardial;Myocardial dysfunction;novel;novel therapeutic intervention;Oxidative Phosphorylation;Pathologic;Pathway interactions;Patients;peer;Phenotype;Physiological;postnatal development;PPAR gamma;pressure;Production;promoter;Proteins;Recovery;Regulation;Regulatory Pathway;Reporter Genes;Resistance;Respiration;response;Response Elements;Role;Shortening Fraction;Signal Pathway;Skeletal Muscle;Stimulus;Stress Tests;System;Testing;therapeutic target;Time;Transcription Coactivator;transcription factor;Work

PROJECT_TITLE: Perm1 is a Novel Regulator of Cardiac Energetics and Function

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CVRS-A(05)]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Hematology;Human Genome;Infectious Diseases;Lymphatic Research;Lymphoma;Rare Diseases

ORG_CITY: BETHESDA

ORG_NAME: HENRY M. JACKSON FDN FOR THE ADV MIL/MED

ORG_STATE: MD

PHR: By elucidating how human T cell leukemia virus type 1 (HTLV-1) causes adult T cell leukemia/ lymphoma, we will understand the basic mechanisms underlying the development of T- and B-cell malignancies and uncover treatment targets and therapeutic approaches hitherto unrecognized.

PI_NAMEs: SNOW, ANDREW L (contact)

PROGRAM_OFFICER_NAME: PARK, EUN-CHUNG

PROJECT_TERMS: Ablation;activating transcription factor;Acute;Address;Adult T-Cell Leukemia/Lymphoma;B lymphoid malignancy;Biological;c-myc Genes;CD4 Positive T Lymphocytes;Cell Cycle;Cell Cycle Arrest;Cell Line;Cell Proliferation;cell transformation;Cells;Characteristics;Chronic;clastogen;Clonal Expansion;Complex;Copy Number Polymorphism;CRISPR/Cas technology;Data;Development;DNA cassette;DNA Damage;DNA Double Strand Break;DNA Sequence;endonuclease;Evolution;Excision;experimental study;Feedback;G1/S Transition;gain of function;gain of function mutation;Gene Combinations;Genes;Genetic Transcription;Genome;genome-wide;Genomic Instability;Genomics;Human;Human Genome;Human T-lymphotropic virus 1;Hypersensitivity;Immune response;Individual;Infection;inhibitor;insertion/deletion mutation;IRF4 gene;Latent virus infection phase;Leucine Zippers;Light;Lymphoma cell;Malignant Neoplasms;Maps;Measures;Mediating;Messenger RNA;Mitotic;Molecular;Mutation;NF-kappa B;nucleic acid structure;Oncoproteins;Pathogenesis;Pathway interactions;Persons;prevent;Process;Productivity;Proliferating;promoter;Proviruses;Recurrence;Regulation;repair enzyme;Resistance;response;Retroviridae;senescence;Signal Transduction;Survivors;synergism;T-Cell Development;T-Lymphocyte;Taxes;Techniques;Testing;Therapeutic;Time;Trans-Activators;Transcript;transcription factor;Transcription Factor AP-1;Transcription-Coupled Repair;transmission process;Tumor Suppressor Proteins;ultraviolet irradiation;Up-Regulation;Variant;Viral;Viral Regulatory Proteins;Virus Diseases;Virus Replication;Xeroderma Pigmentosum

PROJECT_TITLE: HTLV-1 Replication/Reactivation-Induced DNA Damage: Mechanisms and Pathogenesis

STUDY_SECTION: VIRA

STUDY_SECTION_NAME: Virology - A Study Section[VIRA]


ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF CINCINNATI

PHR: Lipoproteins in the circulation are important for the body’s ability to utilize fat. When these lipoproteins are thrown out of balance, they can contribute to cardiovascular disease and other inflammatory disorders. This work is aimed at understanding how a protein called apolipoprotein A-II works to maintain lipoprotein balance, a question that has plagued scientists for nearly 5 decades.

PI_NAMEs: DAVIDSON, W SEAN (contact)

PROGRAM_OFFICER_NAME: LIU, LIJUAN

PROJECT_TERMS: Affect;Agreement;Animal Model;Animals;Apolipoprotein A-I;Apolipoprotein A-II;Apolipoproteins;atherogenesis;atheroprotective;ATP-Binding Cassette Transporters;Cardiovascular Diseases;cardiovascular disorder risk;Cell Surface Receptors;Cells;Chemosensitization;Cholesterol;Cholesterol Homeostasis;Chylomicrons;Circulation;cofactor;Complex;Consensus;Cryoelectron Microscopy;Data;design;Development;Disease;Equilibrium;Experimental Models;experimental study;Fatty acid glycerol esters;Genetic;Genetic Polymorphism;Goals;Hepatocyte;High Density Lipoprotein Cholesterol;High Density Lipoproteins;Human;Hypertriglyceridemia;improved;in vivo;Incubated;Inflammatory;innovation;Knowledge;Ligands;Lipids;Lipolysis;Lipoprotein (a);Lipoprotein Binding;lipoprotein lipase;Lipoproteins;Literature;Low-Density Lipoproteins;Mediating;Metabolic Diseases;Metabolic syndrome;Metabolism;Molecular;Molecular Conformation;Mus;Nature;Non-Insulin-Dependent Diabetes Mellitus;novel;overexpression;particle;Physiological;Plasma;Plasma Proteins;Play;Predisposition;Process;Proteins;Proteome;Proteomics;Public Health;receptor;residence;Resolution;Risk Factors;Role;Scaffolding Protein;Scientist;Structure;Techniques;Technology;Testing;Therapeutic;Time;Triglyceride Metabolism;Triglycerides;uptake;Vascular Diseases;Very low density lipoprotein;Work

PROJECT_TITLE: The molecular basis for the role of apolipoprotein A-II in cholesterol and triglyceride metabolism

STUDY_SECTION: AICS

STUDY_SECTION_NAME: Atherosclerosis and Inflammation of the Cardiovascular System Study Section[AICS]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Infectious Diseases;Microbiome;Nutrition

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: Narrative Clostridioides difficile has a complex metabolism that supports gut colonization as well as capacity to rapidly expand after antibiotic ablation of the commensal microbiota promotes host-based release of nutrient sources via toxin-mediated damage to mucosal surfaces. Using novel methods in nuclear magnetic resonance (NMR) we will clearly define the real-time metabolism of living C. difficile cells, under anaerobic and reducing conditions, to inform metabolic targets in carbon and nitrogen metabolism. Findings will inform functional studies to identify therapeutic targets.

PI_NAMEs: BRY, LYNN  (contact)

PROGRAM_OFFICER_NAME: RANALLO, RYAN

PROJECT_TERMS: Ablation;Acids;Address;Alanine;Alanine Transaminase;Amines;amino acid metabolism;Amino Acids;Anaerobic Bacteria;Antibiotic Therapy;Antibiotics;Bile Acids;Biomass;Carbohydrates;Carbon;Cells;Clinical;Clostridium difficile;commensal microbes;Complex;computer framework;Consumption;defined contribution;Disease;Ecosystem;energy balance;Enzymes;Equilibrium;Ethanolamines;Fermentation;Ferredoxin;Formates;Genes;Genetic;genome-wide;Glutamate Dehydrogenase;Glycolysis;Growth;gut colonization;Hospitals;improved;in vivo;Infection;L Forms;Label;Lyase;Magic;Mediating;Metabolic;metabolic abnormality assessment;Metabolic Pathway;Metabolism;metabolomics;metatranscriptomics;Methods;microbiota;Modeling;Molecular;Mucous Membrane;mutant;Nitrogen;nitrogen metabolism;Nosocomial Infections;novel;Nuclear Magnetic Resonance;Nutrient;Nutrient availability;Outcome;Oxidases;Oxidation-Reduction;pathogen;Pathway interactions;Phase;Phenotype;Physiology;preventive intervention;Production;programs;Pyruvate;rapid growth;recruit;Regulon;resident commensals;Resolution;Role;Serine;small molecule;Source;Surface;System;Therapeutic Intervention;therapeutic target;Time;tool;Toxin;Transaminases;transamination;Virulence

PROJECT_TITLE: NMR-resolved dynamics of C. difficile metabolism

STUDY_SECTION: BACP

STUDY_SECTION_NAME: Bacterial Pathogenesis Study Section[BACP]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences

ORG_CITY: PASADENA

ORG_NAME: CALIFORNIA INSTITUTE OF TECHNOLOGY

ORG_STATE: CA

PHR: Project Narrative  The proposed research is relevant to public health because our ability to diagnose and treat brain disorders is currently limited by our understanding of the fundamental neurobiological mechanisms underlying complex behaviors, and associated brain states such as motivation and arousal. Because of the evolutionary conservation of mammalian brain structures, an understanding of the neural circuitry controlling these processes in the laboratory mouse should yield fundamental concepts and details that are relevant to understanding the human brain. The research described in this proposal will develop innovative new tools that will aid in the functional dissection of neural circuit mechanisms, and is therefore relevant to NIMH's mission of achieving a deeper understanding of fundamental neurobiology and its dysfunction in brain disorders.

PI_NAMEs: ANDERSON, DAVID J (contact)

PROGRAM_OFFICER_NAME: KIM, DOUGLAS SUN-IL

PROJECT_TERMS: Aggressive behavior;anatomical tracing;Animals;Antibodies;Arousal;Atlases;Axon;Behavior;Behavior assessment;Behavior Control;Behavioral;biomarker identification;Brain;Brain Diseases;BRAIN initiative;Calcium;candidate identification;cell type;Cells;Chromosome Mapping;Classification;Cognition;Complex;Data;Diagnosis;Dissection;Electrophysiology (science);emotional behavior;Emotions;ESR1 gene;experimental study;fighting;FOS gene;Functional disorder;Genetic;Goals;Human;Hypothalamic structure;Image;Immediate-Early Genes;improved;in vivo;innovation;interest;Knowledge;Laboratory mice;Link;Maps;Measures;Mediating;Mental disorders;Methods;Mission;Molecular;Motivation;Motor output;National Institute of Mental Health;neural circuit;Neuroanatomy;neurobiological mechanism;Neurobiology;Neurons;Neurosciences;new technology;novel;novel strategies;Opsin;optogenetics;Outcome;patch sequencing;Perception;postsynaptic;Process;Public Health;redshift;Research;Research Personnel;Resolution;response;Role;sensory input;single-cell RNA sequencing;social;Social Behavior;Social Controls;spatiotemporal;Stains;Structure;System;Techniques;Technology;Time;tomography;tool;Tracer;transcriptomics;two-photon;ventromedial hypothalamic nucleus;Viral;Work

PROJECT_TITLE: Region-Specific, Inducible Axonal Tract-Tracing in the Brain

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Genetics;Infectious Diseases;Pediatric

ORG_CITY: BURLINGTON

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE

ORG_STATE: VT

PHR: PROJECT NARRATIVE: Cryptosporidium species are important causes of diarrhea in AIDS patients and children for which improved treatments are needed and under development. However, drug resistance developed in a dairy calf drug efficacy study for one drug lead in under a week, stressing the need for a basic understanding of Cryptosporidium drug resistance. This project will use a suite of novel methods and three lead compounds to develop and validate methods to study the evolution of Cryptosporidium drug resistance and approaches to prevent its occurrence.

PI_NAMEs: HUSTON, CHRISTOPHER D (contact)

PROGRAM_OFFICER_NAME: MO, ANNIE X  Y

PROJECT_TERMS: Acceleration;Acquired Immunodeficiency Syndrome;Address;Amino Acids;Amino Acyl-tRNA Synthetases;Animals;Anti-malarials;Antimicrobial Resistance;Backcrossings;Biological Assay;Cells;Chemicals;Child;Chloroquine;Clustered Regularly Interspaced Short Palindromic Repeats;Code;Combination Drug Therapy;Combined Modality Therapy;Communicable Diseases;Computer Simulation;Cryptosporidiosis;Cryptosporidium;Cryptosporidium parvum;curative treatments;Dairying;Data;Defect;Development;Diarrhea;diarrheal disease;Disease Outbreaks;disorder risk;DNA;Dose;Drug Combinations;drug development;drug efficacy;Drug resistance;drug resistance development;Drug usage;efficacy study;efficacy trial;Engineering;Evolution;experimental study;Failure;fitness;Future;Genes;Genetic;Genetic Epistasis;Genomics;Glean;Goals;Grant;Growth;Immunocompromised Host;improved;In Vitro;in vivo;Infant;Infection;inhibitor;Iowa;Knowledge;Lead;lead series;Life;Link;Malaria;Measurement;Measures;Methionine-tRNA Ligase;Methods;microbial;Modeling;models and simulation;Mus;mutant;Mutation;nitazoxanide;novel;parasite genome;Parasite resistance;Parasites;Patients;Pharmaceutical Preparations;Pharmacology;Pharmacotherapy;Piperazines;Placebos;Positioning Attribute;Predisposition;prevent;Public Health;Recrudescences;reproductive fitness;Resistance;resistance mutation;resistant strain;Resources;response;Risk;Series;Speed;Stress;Suicide;Testing;Time;Transgenic Organisms;Tuberculosis;United States;vector;waterborne;Work

PROJECT_TITLE: Methods to study Cryptosporidium drug resistance

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AIDC-B(83)]


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Bipolar Disorder;Brain Disorders;Clinical Research;Depression;Mental Health;Mental Illness;Neurosciences;Serious Mental Illness

PHR: PROJECT NARRATIVE Major mood disorders are characterized by an inability to regulate one’s emotions; an impairment that can be mapped onto abnormalities in brain circuits that underlie the salience of affectively-laden material and higher- order cognitive control. These deficits contribute to maintenance of the illness as well as functional disability, and they may worsen with age; a pattern which is in contrast to the improvement in emotion regulation noted in healthy older adults. A better understanding of these complex age-related brain changes could point toward novel targets for intervention to promote improved well-being in patients suffering from disabling mood dysregulation.

PI_NAMEs: BURDICK, KATHERINE ELIZABETH (contact);GUNNING, FAITH M

PROGRAM_OFFICER_NAME: LYONS, ELIZABETH ANNE

PROJECT_TERMS: Address;Adult;Affect;Affective;Age;age difference;age related;age related changes;Aging;aging brain;Amygdaloid structure;Attention;attentional bias;Attenuated;Behavior;Biological Assay;Bipolar Disorder;Brain;brain based;Clinical;clinically relevant;Cognition;Cognitive;cognitive control;Cognitive deficits;Complex;Coping Skills;critical period;Depressive disorder;design;Development;Diagnostic;Disabling;Disease remission;Elderly;emotion regulation;Emotional;emotional experience;Emotions;Enrollment;executive function;flexibility;functional disability;Goals;heuristics;Impairment;improved;Intervention;late life;Learning;life span;Maintenance;Major Depressive Disorder;Maps;Measures;Mediating;Memory;Mental Depression;Mental disorders;middle age;Mood Disorders;Moods;National Institute of Mental Health;negative affect;Negative Valence;network dysfunction;novel;older adult;Onset of illness;Outcome;Patient Self-Report;Patients;Pattern;Performance;performance based measurement;Personal Satisfaction;Process;Recurrence;Relapse;Reporting;Research Domain Criteria;Rest;Risk;Sampling;Services;sex as a biological variable;social;social deficits;Social Functioning;Stimulus;Strategic Planning;Structure;Symptoms;therapy design;therapy resistant;Thinking;trait;Well in self;white matter change;Work

PROJECT_TITLE: Brain-based Mechanisms of Emotion Regulation in Aging and Mood Disorders


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences;Women's Health Research

ORG_CITY: ATLANTA

ORG_DEPT: NEUROSCIENCES

ORG_NAME: GEORGIA STATE UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative Behavioral disorders that have a strong social component, such as autism spectrum disorders, are often more common and severe in males than in females. Sexual differentiation of the brain likely contributes to these differences. This research explores the behavioral consequences of sex differences in neural systems implicated in social behavior.

PI_NAMEs: DE VRIES, GEERT J. (contact);PETRULIS, ARAS T

PROGRAM_OFFICER_NAME: BREEDEN, ANDREW LEE

PROJECT_TERMS: Ablation;Acute;Adult;Affect;Amygdaloid structure;Anatomy;autism spectrum disorder;Behavior;Behavior Disorders;Behavioral;Brain;brain control;CASP3 gene;Cell Physiology;Cells;Data;designer receptors exclusively activated by designer drugs;Enterobacteria phage P1 Cre recombinase;Excision;Female;Foundations;Functional disorder;Genetic;genetic approach;Grant;Human;Injections;interest;knock-down;Laboratories;male;mature animal;Medial;Morbidity - disease rate;Mus;nerve supply;neural;neural circuit;Neurons;neuroregulation;Neurotransmitters;Output;pharmacologic;Play;prevent;Production;Research;Rodent;Sex Differences;Sex Differentiation;sexual dimorphism;social;Social Behavior;Social Behavior Disorders;social communication;Social Controls;Steroids;Structure of terminal stria nuclei of preoptic region;System;Testing;theories;tool;Tracer;Translating;Vasopressins;vector control;Vertebrates;Viral Vector;women versus men;Work

PROJECT_TITLE: Sex Differences in the Neural Control of Social Behavior

STUDY_SECTION: NNRS

STUDY_SECTION_NAME: Neuroendocrinology, Neuroimmunology, Rhythms and Sleep Study Section[NNRS]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases;Orphan Drug;Rare Diseases;Tuberculosis

PHR: Project narrative Tuberculosis remains a leading cause of mortality and morbidity. The goal of this proposal is to subvert Mycobacterium tuberculosis adaptation to a fatty acid rich diet. Specifically, we will assign a function to a universal stress protein that is essential to avoid fatty acid toxicity.

PI_NAMEs: EHRT, SABINE  (contact);RODRIGUES BEITES, TIAGO

PROGRAM_OFFICER_NAME: ROBINSON, RICHARD THOMAS

PROJECT_TERMS: Acetylcysteine;Acute;Address;adenosine cyclic-3',5'-monophosphate binding proteins;Affect;Affinity;alpha Tocopherol;Antibiotic Therapy;Antioxidants;Antitubercular Antibiotics;attenuation;Bacillus;bactericide;Biology;Bone Marrow;C3HeB/FeJ Mouse;Carbon;caseating granulomas;Catabolism;Cell Physiology;Cholesterol;Chronic;Clinical;Clinical Trials;Complement;Culture Media;Cyclic AMP;Cytochrome c Reductase;Data;Desire for food;Diet;Doxycycline;Drug Targeting;Drug Tolerance;Electrons;Energy Metabolism;Environment;Enzymes;Etiology;Fatty Acids;folic acid metabolism;Gene Expression;Genes;Genetic;Genetic Determinism;Genus Mycobacterium;Goals;Growth;Heat shock proteins;host colonization;improved;Infection;inhibitor;knock-down;Knock-out;Knowledge;Label;Laboratories;Lead;Lesion;Libraries;Lipid Peroxidation;Lipids;long chain fatty acid;Macrophage;Malate Synthase;Measures;Membrane;Metabolism;metabolomics;minimal inhibitory concentration;Modeling;Morbidity - disease rate;mortality;mouse model;Mus;mutant;Mutate;Mutation;Mycobacterium tuberculosis;NADH;NADH oxidase;Names;new therapeutic target;novel strategies;nucleotide metabolism;Oleic Acids;Operon;Outcome Measure;oxidation;Oxidative Stress;Oxidoreductase;Oxygen Consumption;pathogen;Pathogenesis;Pathogenicity;Pathway interactions;Persons;Pharmaceutical Preparations;Phase;Phenotype;Physiological;Physiology;Play;Predisposition;prevent;Proteins;Protons;Reactive Oxygen Species;Regimen;Research;Respiration;Respiratory Chain;response;Role;screening;Serine;Signal Transduction;Source;Supplementation;System;Testing;Therapeutic;Time;Toxic effect;transposon sequencing;Treatment Protocols;Tuberculosis;tuberculosis drugs;uptake;Work

PROJECT_TITLE: Turning Mycobacterium tuberculosis appetite for fatty acids against itself


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Nanotechnology;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Current vaccines against IAV are designed to largely induce IAV-specific antibodies, and by their design, do not induce the lung resident memory T and B cells that occurs during natural IAV infections and has been shown to be critical for protection against heterologous IAV infections. The H5N1 avian IAV viruses, which have poor immunogenicity, are listed by the CDC as viruses of special concern due their high mortality rate in humans. This project tests our promising biocompatible nanoparticle based IAV vaccine (IAV-nanovax) which induces immunity in the upper and lower airways as well as systemically to determine if it can provide superior, long-term broadly protective immunity and protection against homologous and heterologous IAV strains.

PI_NAMEs: LEGGE, KEVIN L (contact)

PROGRAM_OFFICER_NAME: GORDON, JENNIFER L

PROJECT_TERMS: 1918 influenza pandemic;Animals;Antibodies;Antibody Response;Antigens;Appearance;Avian Influenza;Avian Influenza A Virus;B-Lymphocytes;biomaterial compatibility;Birds;Cessation of life;Cold Chains;combat;Data;Death Rate;design;Development;Dose;Economics;efficacy evaluation;Epidemic;experience;Ferrets;flu;Future;Generations;Goals;Health;Hospitalization;Human;Humoral Immunities;Immunity;Immunization;immunogenic;immunogenicity;Influenza;Influenza A virus;Influenza A Virus, H1N1 Subtype;Influenza A Virus, H5N1 Subtype;Influenza A Virus, H5N2 Subtype;Influenza vaccination;influenza virus strain;influenza virus vaccine;innovation;interest;Lead;Licensing;Lung;Maintenance;Medical Care Costs;Memory;Memory B-Lymphocyte;Morbidity - disease rate;mortality;Mus;nanoparticle;National Institute of Allergy and Infectious Disease;Needles;new pandemic;Nose;novel;novel strategies;pandemic potential;pandemic virus;Pathogenesis;Pathogenicity;Polyanhydrides;Population;Pre-Clinical Model;pre-pandemic;Productivity;Public Health;Research;Research Personnel;respiratory;response;seasonal influenza;Strategic Planning;Structure of mucous membrane of nose;T cell response;T-Lymphocyte;Testing;tissue resident memory T cell;Tissues;Toxic effect;United States;United States National Institutes of Health;universal influenza vaccine;universal vaccine;Vaccination;vaccination strategy;Vaccine Design;vaccine strategy;Vaccines;Variant;Virus;Virus Diseases;Virus Replication;Work

PROJECT_TITLE: Protection and Immunity after Polyanhydride Nanoparticle Vaccination against Avian Influenza A Virus

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AIDC-S(02)]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Infectious Diseases;Microbiome

ORG_CITY: Nashville

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: PROJECT NARRATIVE  The gut microbiota protects against infection by invading pathogens (colonization resistance), such as Salmonella enterica. The proposed research will investigate if propionate, a short-chain fatty acid predicted to mediate colonization resistance, is metabolized by Salmonella in the inflamed gut to regulate invasion and fuel intestinal growth. This work will describe a novel mechanism by which Salmonella overcomes the inhibitory effects of propionate and provide a deeper understanding of how Salmonella thrives in the gut.

PI_NAMEs: SHELTON, CATHERINE  (contact)

PROGRAM_OFFICER_NAME: ALEXANDER, WILLIAM A

PROJECT_TERMS: Ablation;bacterial community;Bacteroides;Bacteroides thetaiotaomicron;Carbon;Catabolism;Cessation of life;Colon;colonization resistance;commensal bacteria;Complex;Data;diarrheal disease;enteric pathogen;Epithelial Cells;experimental study;Exposure to;Fermentation;Fluorescence Microscopy;Gastroenteritis;Gastrointestinal tract structure;Genes;Germ-Free;Growth;gut colonization;gut inflammation;gut microbiota;In Vitro;in vivo;Infection;Inflammation;Inflammatory Response;innovation;insight;Intestines;Invaded;Literature;Measures;Mediating;member;Metabolism;microbiota;Modeling;mouse model;Mus;mutant;Nitrates;non-typhoidal Salmonella;novel;Nutrient;Operon;Oxidants;Oxygen;pathogen;pathogenic bacteria;Pilot Projects;Production;Propionates;Pyruvate;Research;resident commensals;Respiration;Role;Salmonella;Salmonella enterica;Salmonella typhimurium;Series;Signal Transduction;Source;Testing;Toxic effect;Training;usability;Volatile Fatty Acids;Work

PROJECT_TITLE: Mechanism of Salmonella-dependent disruption of propionate-mediated colonization resistance


NIH_SPENDING_CATS: Behavioral and Social Science;Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Emerging Infectious Diseases;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunization;Infectious Diseases;Pediatric;Prevention;Rare Diseases;Social Determinants of Health;Tuberculosis;Vaccine Related;Vaccine Related - AIDS;Women's Health Research

ORG_CITY: SAN FRANCISCO

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative This award will support the CTU to continue its third decade of high impact, globally relevant HIV and TB prevention and therapeutic research, aligned with Network scientific objectives, and in support of Zimbabwe Ministry of Health policy goals, and designed to advance progress toward UNAIDS 95-95-95 targets. The CTU will help to develop future research aims and disseminate lessons learned to inform local, regional, and international efforts and best practices aimed at changing the trajectory of the HIV pandemic, and ultimately, result in its control.

PI_NAMEs: CHIRENJE, ZVAVAHERA MIKE (contact)

PROGRAM_OFFICER_NAME: GREENFIELD, TERI L

PROJECT_TERMS: Adherence;Adolescent;Adult;AIDS clinical trial group;AIDS prevention;Anti-Retroviral Agents;antiretroviral therapy;Award;Breast Feeding;California;Caring;Child;cis-female;clinical research site;Clinical Trials;Clinical Trials Unit;Collaborations;Communities;community advisory board;community engagement;comorbidity;Complex;design;Drug Delivery Systems;Economics;Effectiveness;effectiveness evaluation;empowerment;Enrollment;Ensure;Environment;Epidemiology;Evaluation;experience;Female Adolescents;female sex worker;Fortification;Funding;Goals;Health Policy;high risk;high risk population;HIV;HIV prevention trial;HIV prevention trials network;HIV Vaccine Trials Network;HIV/AIDS;HIV/TB;improved;innovation;International;International Maternal Pediatric Adolescent AIDS Clinical Trials;Intervention;investigator training;Investments;knowledge hub;Laboratories;Lead;men who have sex with men;Mentors;Mentorship;Methodology;Methods;Microbicide Trials Network;Mission;multidisciplinary;neutralizing antibody;next generation;novel;novel strategies;Outcome;pandemic disease;Participant;Pathogenesis;Performance;Pharmacy facility;Phase;Policies;Politics;Population;pre-exposure prophylaxis;pregnant;Prevention;Prevention approach;Prevention Research;Prevention strategy;Preventive vaccine;Research;Research Infrastructure;Research Priority;Role;San Francisco;social;Social Behavior;Technology;Therapeutic;Therapeutic Research;therapeutic vaccine;Training;treatment optimization;Treatment outcome;United States National Institutes of Health;Universities;uptake;vaccine candidate;vaccine trial;Woman;Work;young woman;Zimbabwe

PROJECT_TITLE: UZ-UCSF CTU


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Coronaviruses;Emerging Infectious Diseases;Genetics;Human Genome;Infectious Diseases

ORG_CITY: NEW ORLEANS

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: PROJECT NARRATIVE We will use molecular techniques to assess coronaviruses in a colony of 5,000 rhesus macaques.

PI_NAMEs: MANESS, NICHOLAS JAMES (contact)

PROGRAM_OFFICER_NAME: PLIMACK, MARY KATHERINE BRADFORD

PROJECT_TERMS: 2019-nCoV;Amino Acid Sequence Homology;Animals;betacoronavirus;Birds;Blood;Camels;Canis familiaris;Case Fatality Rates;Cessation of life;Chiroptera;Collection;Common Cold;Coronavirus;coronavirus disease;Coronavirus Infections;COVID-19;COVID-19 impact;COVID-19 pandemic;COVID-19 severity;cross reactivity;Data;Disease;Elements;epidemic potential;Exhibits;Family;Family suidae;Felis catus;Frequencies;Future;Genomics;Health;Human;human coronavirus;Immune;Immunity;Incidence;Infection;interest;Macaca;Macaca mulatta;Middle East Respiratory Syndrome Coronavirus;Modeling;Molecular;Nature;next generation sequencing;nonhuman primate;Nose;novel;novel coronavirus;novel virus;Outcome;pandemic disease;pandemic potential;Phylogenetic Analysis;Play;Primates;Publishing;Rectum;Research;Research Project Grants;response;Role;Sampling;SARS coronavirus;screening;seasonal coronavirus;Seasons;Serology;Site;Swab;Techniques;vaccine evaluation;Viral;Virus;Zoonoses;zoonotic coronavirus

PROJECT_TITLE: Pan Coronavirus Genomic Surveillance of a Large NHP Colony

STUDY_SECTION: GVE

STUDY_SECTION_NAME: Genetic Variation and Evolution Study Section[GVE]


ADMINISTERING_IC: VA

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: Veterans Affairs

ORG_CITY: RICHMOND

ORG_NAME: VA VETERANS ADMINISTRATION HOSPITAL

PHR: Project Narrative This application requests funds to purchase a Zeiss Laser Scanning Confocal Microscope 980 with AiryScan2 imaging capabilities, which will bring state-of-the-art technology not currently available at our research facility. Access to this microscope will substantially facilitate the projects of Drs. Dupree, Huizar, Zhou, Neuwelt, Tan, Ren and Baron, who are all VA-funded investigators working on cutting edge research in areas neurodegenerative disease, cancer, metabolic liver disease, heart arrythmia/disease, movement disorder and head trauma. It will also promote collaborations within the CVHCS and between CVHCS researchers and VA-funded investigators outside the CVHCS consistent with the Enterprise research model initiated by the VA research program.

PI_NAMEs: DUPREE, JEFFREY L. (contact)

PROJECT_TERMS: 3-Dimensional;animal tissue;Area;Biopsy;Carbon Dioxide;Cell Physiology;Cell Survival;Cells;Collaborations;Collection;Computer software;Core Facility;Craniocerebral Trauma;Data;detector;Devices;Dimensions;Disease;Dryness;Elements;Equipment;Extramural Activities;flexibility;fluorescence imaging;Formaldehyde;Funding;Grant;Head;Healthcare Systems;Heart;Heating;Humidity;Image;imaging capabilities;imaging facilities;imaging study;imaging system;Imaging technology;Immersion;improved;Joints;Label;Lasers;Length;lens;live cell imaging;Liver diseases;Malignant Neoplasms;Medical center;Metabolic;Microscope;Microscopy;Minor;Mission;Modeling;Motor;Movement Disorders;Neurodegenerative Disorders;Oils;Pathologic;Patients;Positioning Attribute;Productivity;Program Evaluation;programs;Reproducibility;Request for Applications;Research;research facility;Research Personnel;Research Support;Resolution;Sampling;Scanning;Series;Services;solid state;Specimen;spectrograph;Speed;System;Technology;Time;tissue fixing;translational study;ultra high resolution;United States National Institutes of Health;Veterans;Viola;Virginia

PROJECT_TITLE: The ShEEP request for a ZEISS Laser Scanning Confocal Microscope 980 with Airyscan 2

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 SPLJ-C (01)]


ORG_CITY: OKLAHOMA CITY

ORG_NAME: OKLAHOMA CITY VA MEDICAL CENTER

ORG_STATE: OK

PHR: Project Narrative: A Miltenyi MACSima instrument is requested to enable Oklahoma City VA investigators to perform single-cell, high content imaging of tissue and cells. The ability to quantify large numbers of proteins at the single cell level in tissue sections allows researchers to more deeply interrogate their scientific questions than conventional immunohistochemistry. This instrument will be used for neuroscience, aging, and cancer research studies at this station. Automated iterative fluorescent imaging and associated software produces data at a higher resolution and with tissue context than cytometry methods. This instrumentation will extend the scientific impact of ongoing VA funded studies and increase the speed and rigor of analyses.

PI_NAMEs: FREEMAN, WILLARD M (contact)

PROJECT_TERMS: Aging;anti-cancer research;Antibodies;Area;automated image analysis;Automation;Award;Bar Codes;Basic Science;career;career development;cell preparation;cell type;Cells;Cities;Clinical Sciences;Computer software;Cytometry;Data;Environment;Equipment;flexibility;fluorescence imaging;Freezing;Funding;Future;genome sciences;Grant;Human;Image;imaging system;Imaging technology;Immunohistochemistry;Immunology;Informatics;insight;instrument;instrumentation;K-Series Research Career Programs;Laboratory Animals;Maintenance;Malignant Neoplasms;Methods;Minor;Needs Assessment;Neurosciences;Neurosciences Research;new technology;Nucleic Acids;Oklahoma;programs;Proteins;Proteomics;Reporter;Research;Research Personnel;Research Project Grants;research study;Research Support;Resolution;Sampling;Sampling Studies;Scientist;senescence;senescent cell;Sheep;Shock;Speed;Surveys;System;Technology;Tissue Banks;Tissue imaging;Tissues;Training

PROJECT_TITLE: ShEEP Request for Iterative Imaging System (MACSima)


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Coronaviruses;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Immunotherapy;Infectious Diseases;Influenza;Pneumonia and Influenza;Vaccine Related

ORG_CITY: PHILADELPHIA

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE Killer T cells are mainly thought to target virus-infected cells by recognizing foreign peptides associated with major histocompatibility complex (MHC) class Ia proteins, but recent data show that killer T cells can fight influenza virus infection in mice by recognizing a viral peptide called M-SL9 bound to Qa-1, a protein not usually associated with adaptive immunity. The experiments in this proposal will explore the molecular mechanism of M-SL9 presentation on Qa-1 and will search for additional Qa-1-binding peptides from influenza virus and from a model coronavirus, mouse hepatitis virus. These studies will enhance our understanding of the generation of killer T cell responses and may guide future T cell-based therapies and vaccines against infections and cancer.

PI_NAMEs: HOGAN, MICHAEL JOHN (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: 2019-nCoV;adaptive immunity;Address;Affinity;Alleles;Animal Model;Antigen Presentation;Antigen Presentation Pathway;betacoronavirus;Binding;Biological Assay;Body Weight decreased;career;career development;Categories;CD8-Positive T-Lymphocytes;Cell Line;Cell Physiology;Cell surface;Cell Therapy;cell type;Cells;Cellular biology;Cellular Immunity;Chemicals;Clinical;Code;Communicable Diseases;Complex;Coronavirus;cytokine;Cytolysis;Cytomegalovirus;Cytotoxic T-Lymphocytes;Data;Dendritic Cells;design;Disease;Enzyme-Linked Immunosorbent Assay;Epitopes;Exhibits;experimental study;Family;Feedback;fighting;flu;follow-up;Follow-Up Studies;Foundations;Future;Generations;Genetic Techniques;Goals;Health;HLA-A gene;Homeostasis;Human;human pathogen;Hybridomas;Immune;Immune response;Immunize;immunogenic;immunogenicity;Immunoprecipitation;immunoregulation;Immunotherapy;improved;in vivo;Individual;Infection;Influenza;Influenza A virus;influenza infection;influenza virus strain;influenzavirus;inhibitor;innovation;interest;Investigation;Laboratories;Literature;Lung;Macaca mulatta;Macrophage;Major Histocompatibility Complex;Malignant Neoplasms;Mammals;Maps;Mentors;Messenger RNA;Modeling;Molecular;Monitor;mouse model;multicatalytic endopeptidase complex;Murine hepatitis virus;Mus;Names;Natural Killer Cells;novel;novel vaccines;Open Reading Frames;pathogen;Pathway interactions;Peptide Signal Sequences;Peptides;polypeptide;prevent;Primates;Process;Productivity;protein complex;Proteins;Proteolytic Processing;Publishing;Qa-1 Antigen;Reading Frames;Reagent;Refractory;Regulation;Reporter;Research;respiratory virus;response;RNA vaccine;Senior Scientist;Severities;Severity of illness;SIV;Sorting;Stains;Surveys;symposium;T cell response;T cell therapy;T-Cell Activation;T-Lymphocyte;T-Lymphocyte Epitopes;tandem mass spectrometry;Testing;vaccination strategy;Vaccine Therapy;Vaccines;vector vaccine;Viral;Viral Genome;Virus;Virus Diseases

PROJECT_TITLE: Defining antiviral T cell responses restricted to the non-classical MHC class Ib molecule, Qa-1

STUDY_SECTION: AITC

STUDY_SECTION_NAME: Allergy, Immunology, and Transplantation Research Committee[AITC]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurosciences;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

ORG_DEPT: PSYCHIATRY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE This R61/R33 study examines the impact of structural racism (SR) on substance use risk via brain structure, function and reward-related decision making in Puerto Rican adolescents living in the mainland US, mostly in New York and in Puerto Rico. During the R61 phase (n=36 in NY; n=36 in PR), we will establish a relationship between SR, between the brain structure, function and reward-related decision making; during the R33 phase, (n=80 in NY; n=80 in PR), we will determine if SR increases substance use risk via the changes brain and behavior, as well as examine neighborhood- and family-level protective factors. Findings will suggest novel structural, family and individual points of intervention by shedding light on neurocognitive mechanisms by which SR can increase substance use risk.

PI_NAMEs: CHAVEZ, LIGIA M.;DUARTE, CRISTIANE S.;SUSSMAN, TAMARA  (contact)

PROGRAM_OFFICER_NAME: PRABHAKAR, JANANI

PROJECT_TERMS: Address;Adolescence;Adolescent;adolescent substance use;Adult;aged;alcohol use disorder;Anterior;Area;Behavior;behavioral outcome;Belief;Brain;Brain imaging;Brain region;brain volume;Buffers;Businesses;Censuses;Child;Childhood;Church;cingulate cortex;cohort;community advisory board;Data;Decision Making;Disadvantaged;discounting;Discrimination;disorder risk;Dorsal;Education;Environment;environmental adaptation;ethnoracial;ethnoracial minority;Exclusion;Family;Female;Future;gray matter;Health;health inequalities;Home;Housing;Income;indexing;Individual;Inequity;Insula of Reil;intergenerational;Intervention;Investments;Lateral;Latinx;Laws;Light;low socioeconomic status;Magnetic Resonance Imaging;Measures;Medial;Mediating;minority children;Minority Groups;Modeling;Murder;neighborhood disadvantage;Neighborhoods;neural;Neurocognition;Neurocognitive;Neurophysiology - biologic function;Neurosciences;New York;novel;novel strategies;Outcome;parent-child communication;parental monitoring;Performance;Phase;Policies;Prefrontal Cortex;Prevalence;Prevention;Prevention approach;prospective;protective factors;Public Health;Puerto Rican;Puerto Rico;Race;racial difference;Recording of previous events;Rewards;Risk;Sampling;Shapes;social;social learning;Social Psychology;Structural Racism;Structure;substance use;Substance Use Disorder;Symptoms;System;violence exposure;Work;Youth

PROJECT_TITLE: Structural Racism, Neurocognition in Reward Related Decision Making and Substance Use Risk

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 BSW-N (M1)]


ADMINISTERING_IC: AA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

ORG_CITY: BINGHAMTON

ORG_DEPT: PSYCHOLOGY

ORG_NAME: STATE UNIVERSITY OF NY,BINGHAMTON

PHR: PROJECT NARRATIVE OVERALL COMPONENT The Developmental Exposure Alcohol Research Center (DEARC) utilizes rodent models of early life ethanol exposure to examine how early developmental exposure to alcohol makes individuals susceptible to alcohol misuse, compromises neurobehavioral function, and adversely impacts the trajectory of healthy aging. The DEARC will focus on two primary neurodevelopmental periods when ethanol exposure is most prevalent: during gestation through maternal consumption of alcohol; and during adolescent exposure, a key age for initiation of alcohol use characterized by binge and high-intensity drinking that are less common for adults. The work of the Center will contribute significantly to our understanding of the biological basis of Alcohol Use Disorders and its long-term consequences.

PI_NAMEs: DEAK, TERRENCE  (contact)

PROGRAM_OFFICER_NAME: POWELL, ELIZABETH

PROJECT_TERMS: Acceleration;Achievement;Adolescence;Adolescent;adolescent alcohol exposure;Adult;adverse outcome;Affective;Age;Aging;aging brain;Alcohol consumption;alcohol exposure;alcohol misuse;alcohol research;alcohol use disorder;alcohol use initiation;Alcohols;Area;Behavioral;Biological;Brain;career;Career Choice;Characteristics;Cognitive;Collaborations;Communities;design;Development;Dose;drinking;effective therapy;Environment;Ethanol;fetal;Functional disorder;Funding;Future;Genotype;Goals;Grant;healthy aging;high intensity drinking;Human;Impaired cognition;Individual;Leadership;Life;life span;maternal alcohol use;Measures;Mediating;Modeling;National Institute on Alcohol Abuse and Alcoholism;neurobehavioral;New York;Outcome;outreach;Pathologic;pathological aging;Pattern;Pilot Projects;Positioning Attribute;Predisposition;Pregnancy;prenatal;prenatal influence;Process;Productivity;Publications;Research;Research Personnel;Resources;Rodent Model;Route;Schools;Series;sex;Sex Differences;social media;Strategic Planning;Structure;symposium;synergism;System;Transgenic Organisms;United States National Institutes of Health;Universities;web site;Work

STUDY_SECTION_NAME: Special Emphasis Panel[ZAA1 DD (60)]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Neurosciences;Substance Misuse

PROJECT_TERMS: Acceleration;Administrator;Advisory Committees;alcohol exposure;alcohol research;Alcohols;Applications Grants;Behavioral;Brain;Budgets;career;Cognitive;Collaborations;Communication;Communities;Computer software;Development;developmental neurobiology;Educational workshop;effective therapy;Ensure;Environment;Equipment;Ethanol;Fostering;Future;Goals;Grant;Information Dissemination;International;Leadership;meetings;Mission;National Institute on Alcohol Abuse and Alcoholism;Neurobiology;organizational structure;Outcome;Participant;Periodicals;Pilot Projects;Play;Policies;Postdoctoral Fellow;pre-doctoral;Procedures;programs;Protocols documentation;Quality Control;Reproducibility;Reproducibility of Results;Research;Research Infrastructure;Research Personnel;Resources;Role;Scientist;Services;social;Societies;Standardization;Strategic Planning;Structure;success;symposium;tool;Training;Training Programs;Universities;Vision;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Neurosciences;Pediatric;Substance Misuse;Underage Drinking

PI_NAMEs: JENTSCH, J. DAVID  (contact)

PROJECT_TERMS: Adolescent;adolescent alcohol exposure;Advisory Committees;Age;alcohol exposure;alcohol research;Alcohols;Area;Automobile Driving;Award;Behavioral;Brain;Brain Stem;Budgets;career;cholinergic;Collaborations;Communities;Contracts;Creativeness;Development;differential expression;Direct Costs;Eligibility Determination;Ethanol;Extramural Activities;Faculty;Fetal Alcohol Exposure;Fiber;Fostering;Funding;Funding Mechanisms;Future;gene network;Genes;Goals;Growth;Hour;Impairment;Incubators;Individual;innovation;Institution;interest;Investments;Learning;Maintenance;member;Mentors;Mentorship;Methods;Mission;Modeling;Monitor;neuroadaptation;neurobehavioral;new technology;novel;optogenetics;peer;Photometry;Pilot Projects;Play;prenatal;Process;Productivity;professor;Program Reviews;programs;psychologic;Psychological reinforcement;Radial;Rattus;Recording of previous events;Reporting;Research;Research Personnel;Research Priority;Resources;Rewards;Role;Science;Scientific Advances and Accomplishments;Scientist;Seasons;sex;Structure;success;synergism;Talents;technology development;tenure track;Testing;Tissue-Specific Gene Expression;Tissues;transcriptome sequencing;transcriptomics;Underrepresented Populations;United States National Institutes of Health;Universities;Ventral Tegmental Area;Work

PROJECT_TITLE: Pilot Project Core


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Genetics;Neurosciences;Pediatric;Substance Misuse;Underage Drinking;Women's Health Research

PROJECT_TERMS: Acute;Adolescence;Adolescent;adolescent alcohol exposure;Adult;Adult women;Affect;Alcohol consumption;alcohol exposure;alcohol misuse;alcohol research;alcohol response;alcohol testing;alcohol use disorder;Autoreceptors;Behavior;behavior influence;Behavioral;Biological Factors;Brain;Cells;Chromosome Structures;Chronic;chronic alcohol ingestion;critical developmental period;Development;differential expression;Dopamine;dosage;Dose;drinking;drinking behavior;drinking water;Drug Kinetics;early adolescence;Estrogens;Ethanol;Exhibits;Female;Four Core Genotypes;Genes;Genetic study;Genome engineering;Goals;Gonadal Hormones;Gonadal Steroid Hormones;Health;Human;Hypothalamic structure;Impaired cognition;Intake;Karyotype;Knowledge;life span;male;Measures;Mediating;Mind;Motivation;Mus;negative affect;neuroadaptation;neurochemistry;neuroregulation;Neurotransmitters;Nucleus Accumbens;Ovary;Oxytocin;Oxytocin Receptor;Pattern;Periodicity;pharmacokinetics and pharmacodynamics;Phase;Phenotype;Ploidies;preference;Psychological Factors;Rattus;receptor expression;Regulation;Reporting;reuptake;Rodent;Role;Scanning;Schedule;segregation;sex;Sex Bias;Sex Chromosomes;Sex Differences;sexual dimorphism;sociocultural determinant;statistics;Subgroup;System;Teenagers;Testing;Testis;Testosterone;transmission process;underage drinking;Water;Work;X Chromosome;X Inactivation;Y Chromosome

PROJECT_TITLE: Sex Chromosome Complement and Mechanisms of Escalating Ethanol Intake in Adolescence


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alcoholism, Alcohol Use and Health;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Pediatric;Prevention;Substance Misuse;Underage Drinking

PI_NAMEs: SAVAGE, LISA M (contact)

PROJECT_TERMS: Acceleration;Adolescence;Adolescent;adolescent alcohol exposure;Adult;Affect;Age;age acceleration;Age Months;age related;Age related pathologies;Age-associated memory impairment;Aging;aging process;aging related disease;Alcohol consumption;alcohol exposure;alcohol research;alcohol risk;alcohol use disorder;Alcohols;Alleles;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease related dementia;Alzheimer's disease risk;Amyloid beta-Protein;Animal Model;apolipoprotein E-4;Behavioral;binge drinking;Brain;Brain Injuries;Brain Pathology;Brain region;Categories;Cell Death;Cell Death Signaling Process;Cells;cholinergic;cholinergic neuron;chronic alcohol ingestion;Classification;Cognitive;Cognitive aging;Data;decrease resilience;Dementia;Development;Diagnosis;Disease;Ethanol;Exercise;experimental study;Exposure to;Female;Functional disorder;Goals;Heavy Drinking;Hippocampus;human data;hyperphosphorylated tau;Impaired cognition;improved;Inbred F344 Rats;Individual;life span;Link;male;Mediating;Mediator;Memory impairment;Modeling;modifiable risk;Molecular;mouse model;neural;neurogenesis;neuropathology;neurotrophic factor;NGFR gene;NGFR Protein;normal aging;novel;novel therapeutics;Outcome;Pathologic;pathological aging;Pathology;Pathway interactions;Persons;Phenotype;Phosphotransferases;Play;pre-clinical;Pre-Clinical Model;Predisposition;prevent;Rattus;receptor;Recording of previous events;Recovery;resilience;response;Risk;Risk Factors;Rodent;Role;Running;Series;sex;spatial memory;Structure;tau-1;Testing;Therapeutic;therapeutically effective;therapy development;Transgenes;Tropomyosin;Water

PROJECT_TITLE: Sex Specific Acceleration of Pathological Aging After AIE


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alcoholism, Alcohol Use and Health;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Dementia;Neurodegenerative;Neurosciences;Pediatric;Substance Misuse;Underage Drinking;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

PROJECT_TERMS: abeta deposition;Abstinence;Acute;Adolescence;Adolescent;Adult;age difference;age group;Age Months;Alcohol consumption;alcohol effect;alcohol exposure;alcohol research;alcohol use disorder;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease related dementia;Amyloid beta-Protein;angiogenesis;Anxiety;Architecture;Autopsy;Biological;Blood - brain barrier anatomy;Blood Vessels;Blood-Borne Pathogens;blood-brain barrier disruption;blood-brain barrier permeabilization;brain parenchyma;Brain region;cell type;Cells;Central Nervous System;Cerebral Amyloid Angiopathy;Chronic;Compensation;Deposition;Development;drinking;emerging adult;Ethanol;familial Alzheimer disease;Family;Female;Functional disorder;Gene Expression Profiling;Genetic Transcription;glial activation;Goals;Hemorrhage;Human;hyperphosphorylated tau;Immune;Immunologics;inhibitor;insight;Knowledge;Life;macromolecule;male;Mental Depression;Microglia;Minocycline;Nervous System Physiology;Neuroglia;neuroinflammation;Neurons;neurovascular;novel;occludin;Outcome;Pathologic;Pattern;Pericytes;Permeability;Phenotype;Play;postnatal;prenatal;prevent;Proteins;psychological distress;Rat Transgene;Rattus;Recording of previous events;Regulation;Reporting;response;Role;seal;sex;Source;suicidal;Testing;Tight Junctions;Transgenes;Transgenic Mice;underage drinking;vascular cognitive impairment and dementia;Vascular Dementia;VEGFA gene;Waxes;Work

PROJECT_TITLE: AIE, Blood-Brain Barrier Regulation, and Neurovascular Integrity in Amyloidopathy


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Depression;Mental Health;Mental Illness;Neurosciences;Pediatric;Substance Misuse;Underage Drinking;Women's Health Research

PI_NAMEs: WERNER, DAVID F (contact)

PROJECT_TERMS: Acceleration;Acute;Adolescence;Adolescent;Adult;adverse outcome;Affect;Affective;aged;Agonist;Alcohol consumption;alcohol exposure;alcohol research;alcohol sensitivity;alcohol use disorder;alcohol use initiation;Alcohol withdrawal syndrome;Alcohols;Amygdaloid structure;Anatomy;Anhedonia;antagonist;Anti-Anxiety Agents;Anxiety;anxiety-like behavior;associated symptom;Behavior;Behavioral;binge drinking;boys;Brain;Brain region;Cells;Chronic;critical period;depressive symptoms;design;Development;Diagnosis;Down-Regulation;drinking;dysphoria;early adolescence;early alcohol use;Electrophysiology (science);Ethanol;Female;Female Adolescents;Functional disorder;gamma-Aminobutyric Acid;Gene Expression;girls;high risk;Human;Individual;LacZ Genes;male;Male Adolescents;Measures;negative affect;negative emotional state;neural;neuroadaptation;neuromechanism;Neurons;Neuropeptides;novel;Oxytocin;Oxytocin Receptor;pharmacologic;Population;postnatal;preservation;Rat Transgene;Rattus;reduce symptoms;Regulation;Rodent;sex;Sex Differences;sexual dimorphism;Signal Transduction;Spiders;Stress;Synapses;System;Testing;TP53 gene;underage drinking;Up-Regulation;Vasopressin Receptor;Vasopressins;Withdrawal;women's diagnosis;Work;young adult

PROJECT_TITLE: Sex-specific Mechanisms of Ethanol Withdrawal During Adolescence


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Chronic Pain;Conditions Affecting the Embryonic and Fetal Periods;Fetal Alcohol Spectrum Disorders (FASD);Intellectual and Developmental Disabilities (IDD);Neurosciences;Pain Research;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Substance Misuse;Underage Drinking

PI_NAMEs: DIAZ, MARVIN RAFAEL (contact)

PROJECT_TERMS: Abstinence;Acute;addiction;Adolescence;Adolescent;adolescent alcohol exposure;Adult;adverse outcome;Affect;Affective;Age;Alcohol consumption;alcohol effect;alcohol exposure;alcohol misuse;alcohol research;alcohol use disorder;Alcohols;Anterior;anxiety-like behavior;Attention;Automobile Driving;Behavior;Behavioral;behavioral outcome;cell cortex;Cells;Chronic;chronic pain;chronic painful condition;cingulate cortex;Clinical;critical developmental period;critical period;Data;Development;Dopamine;Dopamine D1 Receptor;dopamine system;dopaminergic neuron;early pregnancy;Electrophysiology (science);Equilibrium;Ethanol;Female;Fetal Alcohol Exposure;Functional disorder;Future;Genetic;Glutamates;Health;hippocampal pyramidal neuron;Individual;Light;Link;male;mechanical allodynia;Mechanics;Midbrain structure;Modeling;negative affect;Nervous System;neural;neural circuit;neuroadaptation;Neurobiology;neurodevelopment;neurogenesis;neuromechanism;Neurons;Neurophysiology - biologic function;Nociception;novel;Nucleus Accumbens;optogenetics;Pain;pain perception;patch clamp;Pathologic;Pattern;Periodicity;postsynaptic;pre-clinical;prenatal;presynaptic;Rattus;Receptor Activation;response;Risk;Risk Factors;Role;Scanning;sex;Slice;social anxiety;Societies;synaptic function;synaptogenesis;synergism;System;Testing;transmission process;Ventral Tegmental Area

PROJECT_TITLE: Anterior Cingulate Dysfunction in a PAE-AIE Combined Model During Protracted Abstinence


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Genetics;Neurosciences;Opioid Misuse and Addiction;Opioids;Prescription Drug Misuse;Substance Misuse

ORG_CITY: SAINT LOUIS

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Oxycodone is the 3rd highest contributor to opioid overdose deaths behind heroin and fentanyl in the United States and remains widely prescribed. Avoiding oxycodone withdrawal has been citied as a reason for misuse and relapse amongst opioid-dependent individuals. In the present proposal the central amygdala will be evaluated for its contributions to oxycodone withdrawal with goal of generating a more targeted approach to treat opioid use disorder.

PI_NAMEs: SLIVICKI, RICHARD  (contact)

PROGRAM_OFFICER_NAME: LIN, YU

PROJECT_TERMS: Acute;Address;affective disturbance;Affective Symptoms;Agreement;Amygdaloid structure;Award;Behavior;behavior influence;Behavioral;Brain region;career;Cell Nucleus;cell type;Collaborations;common treatment;Data Analyses;Data Set;Dependence;Development;drug craving;drug relapse;drug seeking behavior;experimental study;Exposure to;Fentanyl;Fluorescent in Situ Hybridization;Foundations;Future;Generations;Genes;Genetic;Genetic Recombination;Genetic Transcription;Goals;Heroin;Incubated;Individual;Intake;Knowledge;Lead;Lesion;Maintenance;Mentors;Modeling;Molecular;Morphine;Mus;negative affect;neuronal excitability;Neurons;Operative Surgical Procedures;Opiate Addiction;Opioid;opioid mortality;opioid overdose;opioid use disorder;opioid withdrawal;Oral;overdose death;Oxycodone;oxycodone seeking;Pain Disorder;Pharmaceutical Preparations;Pharmacology;Phase;Phenotype;physical symptom;Physiological;Population;Predisposition;Preparation;prescription opioid;prevent;programs;promoter;recombinase;Relapse;Research;Rodent Model;Role;Sampling;Scientist;Self Administration;single-cell RNA sequencing;skills;Symptoms;synthetic opioid;System;Tamoxifen;Technical Expertise;Techniques;Therapeutic;therapy development;Tissue imaging;Training;transcriptome sequencing;transcriptomics;United States;Withdrawal;Withdrawal Symptom;Work

PROJECT_TITLE: Functional and molecular characterization of the central amygdala in the context of oxycodone withdrawal

STUDY_SECTION: NIDA

STUDY_SECTION_NAME: Career Development Education and Training Study Section[NIDA-K]


NIH_SPENDING_CATS: Brain Disorders;Comparative Effectiveness Research;Dissemination and Implementation Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

PHR: PROJECT NARRATIVE The Learning for Early Careers in Addiction and Diversity (LEAD) Program at the University of California, San Francisco continues its mission to address the racial gap in NIH funding. The Program provides training to early- stage researchers from historically underrepresented groups (URG) to increase the number who conduct behavioral or pharmacological substance use and substance use disorders research. The ultimate goal is to improve diversity in addiction research leadership and strengthen the research and training network of NIH and the scientific community.

PI_NAMEs: MASSON, CARMEN L (contact);ST.HELEN, GIDEON

PROGRAM_OFFICER_NAME: HIGHSMITH, KEISHER S

PROJECT_TERMS: addiction;Address;Applications Grants;Award;Behavioral;California;career;career development;Career Mobility;Clinical;Clinical Research;Clinical Sciences;Clinical Trials;Clinical Trials Design;Clinical Trials Network;Communities;Data;design;Development;Disparity;education research;Educational Curriculum;Educational process of instructing;Educational workshop;Effectiveness;Ethics;ethnic minority;ethnic minority population;Evaluation;Evidence based treatment;experience;Face;Faculty;Fostering;Funding;Goals;Grant;health care service organization;health disparity;Health Policy;implementation research;implementation science;improved;Infrastructure;innovation;Institution;K-Series Research Career Programs;Leadership;Learning;meetings;Mentors;Mentorship;Methodology;Methods;Mission;National Clinical Trials Network;National Institute of Drug Abuse;next generation;Outcome Measure;Pharmacologic Substance;Pilot Projects;Postdoctoral Fellow;professor;programs;Race;racial minority;racial minority population;recruit;Research;research and development;research based treatment;research data dissemination;Research Methodology;Research Personnel;Resources;San Francisco;Science;Scientist;Secure;Senior Scientist;Site;skills;sound;Structure;substance use;Substance Use Disorder;support network;Testing;tool;Training;Training Programs;Translational Research;treatment research;Underrepresented Populations;United States National Institutes of Health;Universities;Work;Writing

PROJECT_TITLE: Mentoring Emerging Scientists for Careers in Substance Use Research

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 MXS-T (M3)]


NIH_SPENDING_CATS: Genetics;Nutrition;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: HOUSTON

ORG_DEPT: GENETICS

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: PROJECT NARRATIVE Systemic inflammation is necessary for effective disease response mechanisms but has significant harmful effects to human health in chronic or dysregulated settings, such as clonal hematopoiesis, the overrepresentation of mutant hematopoietic clones. Hematopoietic stem and progenitor cells govern the response to these diseases and are responsive to cues associated with inflammation, therefore it is necessary to identify new inflammatory signals that influence these cells’ behavior. Here, we found that acetate, a diet-associated metabolite which rises during systemic inflammation, may regulate the inflammatory response in these stem cells which we will test using a combination of functional, gene expression, and phenotypic studies of HSPCs in response to acetate during inflammation.

PI_NAMEs: TIESSEN, JONATHAN  (contact)

PROGRAM_OFFICER_NAME: GILLASPY, ALLISON

PROJECT_TERMS: Acetate-CoA Ligase;Acetates;Acetyl Coenzyme A;Adult;ATP Citrate (pro-S)-Lyase;Bacterial Infections;Biological Assay;Bolus Infusion;cell behavior;Cells;Cellular biology;ChIP-seq;Chronic;Citrates;Combined Modality Therapy;Consumption;Cues;cytokine;Data;Diet;dietary;Dietary Component;Disease;epigenetic profiling;epigenetic regulation;Fructose;Gene Expression;Gene Expression Profiling;Genes;Genetic;Goals;Health;Hematopoiesis;Hematopoietic;Hematopoietic stem cells;Hematopoietic System;Histone Acetylation;Human;Immune;immune function;Immune response;Immunophenotyping;immunoregulation;Inflammation;Inflammation Mediators;Inflammatory;inflammatory modulation;Inflammatory Response;Interferons;Interleukins;Link;Lipopolysaccharides;Literature;Maintenance;Measures;Mediator;Metabolic;Metabolism;Modeling;mouse model;Mus;mutant;Mutant Strains Mice;Mutation;Natural regeneration;novel;Phenotype;Production;Proteomics;Public Health;Publishing;response;Role;Serum;Signal Transduction;single molecule;Sorting;Source;stem cell biology;stem cell expansion;stem cell function;stem cells;Stimulus;Supplementation;systemic inflammatory response;Testing;transcriptome sequencing;Transplantation;Work

PROJECT_TITLE: Acetate as a Mediator of Hematopoietic Stem Cell Inflammatory Response and Clonal Hematopoiesis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F07C-K(20)]


ADMINISTERING_IC: NS

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: Project Narrative The cortex is made up of two main classes of cells, excitatory pyramidal cells and inhibitory interneurons, however, there exists a cell type that is dissimilar from both. The long-range inhibitory neuron is remarkable in its unique morphology and gene expression profile, and this cell type likely plays a similarly unique role in cortical circuit function. Here, I set out to characterize this cell type and test the hypothesis that it regulates the generation of low-frequency oscillations in the cortex.

PI_NAMEs: RATLIFF, JACOB  (contact)

PROGRAM_OFFICER_NAME: HE, JANET

PROJECT_TERMS: Address;Affect;Animals;Area;area striata;Arousal;Attention;Axon;Behavioral;Brain;Cell Shape;cell type;Cells;Cerebral cortex;Code;Cognition;D Cells;Data;Electroencephalography;Electrophysiology (science);excitatory neuron;experimental study;extracellular;Frequencies;Gene Expression;Gene Expression Profile;Generations;Genetic;imaging modality;Impairment;in vivo;inattention;inhibitory neuron;Interneurons;Knowledge;Light;Locomotion;Maintenance;Measures;Memory;Mental disorders;Microscopy;millimeter;Minority;Modeling;Morphology;Mus;Muscle;Neocortex;neocortical;Neurons;neuropsychiatric disorder;Nitric Oxide Synthase Type I;Opsin;optogenetics;Output;Pattern;Play;Positioning Attribute;postsynaptic;prevent;Pyramidal Cells;Recurrence;response;Role;Sensory;sensory input;Signal Transduction;Sleep;Slice;Slow-Wave Sleep;Somatostatin;Specificity;Synaptic plasticity;Task Performances;Test Result;Testing;Tissues;tool;two photon microscopy;two-photon;Work

PROJECT_TITLE: The Role of Long-Range Inhibitory Neurons in Cortical Circuits


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: American Indian or Alaska Native;Biomedical Imaging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Lung Cancer;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Rural Health

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

PHR: Project Narrative Lung cancer is the leading cause of cancer death among American Indians and Alaska Natives (AI/AN), who experience disparities in lung cancer incidence, stage at diagnosis, survival, and mortality. The advent of lung cancer screening (LCS) is an evidence-based intervention to reduce mortality from lung cancer, but the implementation of LCS has not adequately performed or evaluated in healthcare settings serving AI/AN patients. The TEALS tribal-academic collaboration will implement an effective community-centered LCS delivery system for AI/AN, and lay the foundation for future patient-level research on LCS.

PI_NAMEs: NAGYKALDI, ZSOLT J (contact)

PROGRAM_OFFICER_NAME: CROSWELL, JENNIFER

PROJECT_TERMS: Address;Administrator;Affect;aged;Alaska;Alaska Native;American Indians;Attention;authority;Behavior Therapy;Breast Cancer Detection;Cancer Center;Cancer Etiology;cancer health disparity;care coordination;care delivery;Caring;Cessation of life;Choctaw Nation of Oklahoma;cigarette smoke;clinical practice;Communities;community based participatory research;community engagement process;Community Health Systems;Community Healthcare;community involvement;community setting;community-centered;comparison control;Complex;Consultations;Control Groups;Country;Coupling;design;Detection;Development;Diagnosis;Disparity;Dissemination and Implementation;dissemination science;early screening;Eligibility Determination;Evaluation;Evidence based intervention;experience;Feedback;Focus Groups;Foundations;Future;General Population;Goals;group intervention;Guidelines;Health;health care delivery;health care settings;Health Professional;Health Sciences;Health Services;Health system;Healthcare Systems;implementation evaluation;implementation process;implementation science;implementation trial;improved;Incidence;Individual;Infrastructure;Intervention;Interview;Knowledge;Link;Location;low dose computed tomography;Lung;lung cancer screening;Malignant neoplasm of lung;Malignant Neoplasms;Mammography;Measures;member;men;mortality;Names;Native Americans;Native-Born;novel;Oklahoma;Outcome;Participant;Patient Care;patient navigation;Patients;Persons;pilot test;Population;preference;Preventive service;Primary Care;primary care practice;Process;programs;Protocols documentation;Randomized;randomized, clinical trials;Recommendation;Research;Research Personnel;Resource-limited setting;Running;Rural;screening;screening guidelines;screening participation;screening program;Services;smoking cessation;Stage at Diagnosis;Structure;System;system-level barriers;Testing;theories;tribal community;tribal health;tribal member;Tribal-academic partnership;Tribes;United States Centers for Medicare and Medicaid Services;United States Preventative Services Task Force;Universities;uptake;Woman;Work

PROJECT_TITLE: Tribally Engaged Approaches to Lung Screening (TEALS)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-V(51)R]


NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Neurosciences

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Anxiety disorders are characterized by problems learning about potentially dangerous situations, particularly when possible outcomes in a situation are uncertain. The present application proposes to use neural and computational approaches to understand why people high in anxiety have difficulties learning about uncertainty and why uncertain situations are avoided in and outside of the laboratory. The goal of this application is to determine what learning difficulties are present in anxiety in order to develop more effective treatments that target these learning difficulties.

PI_NAMEs: BROWN, VANESSA  (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: Anxiety;Anxiety Disorders;anxiety treatment;anxious;Arousal;Association Learning;avoidance behavior;Behavior;Behavior assessment;behavior measurement;Behavioral;Brain;career;Clinical;clinical predictors;clinically relevant;Complex;computer framework;Computer Models;Dangerousness;depressive symptoms;Diagnosis;Diagnostic;Disease;Ecological momentary assessment;effective therapy;experience;Fright;Functional Magnetic Resonance Imaging;functional MRI scan;Future;Goals;Impairment;improved;Individual Differences;individual variation;Interview;Laboratories;Learning;Learning Difficulty;Link;Maps;Measures;Mental disorders;Mentors;Modeling;National Institute of Mental Health;neural;Neurobiology;neuroimaging;neuromechanism;novel;Outcome;Participant;Patient Recruitments;Performance;Persons;Play;prevent;Process;Psychiatry;Psychologist;Questionnaires;remediation;Reporting;Research;response;Role;Sampling;Scientist;Signal Transduction;Specificity;Stimulus;Symptoms;Task Performances;Testing;theories;tool;Training;Training Activity;Uncertainty;Universities;Update;Visit

PROJECT_TITLE: Neurocomputational substrates of maladaptive uncertainty learning and avoidance in anxiety

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


NIH_SPENDING_CATS: Autoimmune Disease;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Multiple Sclerosis;Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Narrative  We recently developed a PET radioligand for K+ channels in the brain that can detect demyelinated lesions in animal models non-invasively. Here, we propose to examine this tracer in rodents, monkeys and humans to further understand the applications and performance of this tracer.

PI_NAMEs: BRUGAROLAS, PEDRO  (contact)

PROGRAM_OFFICER_NAME: UTZ, URSULA

PROJECT_TERMS: 4-Aminopyridine;Alzheimer's Disease;Animal Model;Architecture;Area;Axon;Binding;Biochemical;Blood - brain barrier anatomy;Blood specimen;Brain;Brain imaging;Brain Ischemia;Central Nervous System;Clinical;Clinical Research;Complement;Craniotomy;Data;Demyelinating Diseases;Demyelinations;design;Diagnosis;Disease;Drug usage;Evaluation;experimental study;FDA approved;Fiber;first-in-human;Future;Genetic;Goals;Histologic;Human;Image;Imaging Device;imaging properties;Immunologics;Inflammation;information gathering;injured;Injury;Ischemia;kinetic model;Kinetics;Lesion;leukodystrophy;Macaca mulatta;Magnetic Resonance Imaging;Measures;Metabolic;Metabolism;Methods;microPET;Minor;Modeling;Monitor;Monkeys;Motor;Multiple Sclerosis;Myelin;Myelin Sheath;Myelin Water Imaging;Neurobehavioral Manifestations;Neurons;nonhuman primate;normal aging;novel;Nutrient;overexpression;Pathologic Processes;Penetration;Performance;Pharmaceutical Preparations;Positron-Emission Tomography;Potassium Channel;Primates;Procedures;Process;Property;quantitative imaging;radioligand;radiotracer;Rattus;remyelination;Rodent;Rodent Model;Role;Scanning;Sensory;Severity of illness;Signal Transduction;Speed;spinal cord and brain injury;Stroke;Target Populations;Testing;therapy development;Time;Tracer;Traumatic Brain Injury;Voltage-Gated Potassium Channel;Walking

PROJECT_TITLE: Can [18F]3F4AP Detect Brain Demyelination? Evaluation of Novel PET Tracer in Nonhuman Primates and Humans

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


NIH_SPENDING_CATS: Complementary and Integrative Health;Immunotherapy;Microbiome;Organ Transplantation;Rare Diseases;Transplantation;Wound Healing and Care

ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE The strength of an immune response against a transplanted organ depends on the extent of genetic disparities between the donor and the host. We have shown that the microbiota, the community of microbes that colonize the body, is an additional novel factor that can modulate this response. We will investigate both how microbial location in the body differentially impacts transplant outcome, as well as delineate the mechanism by which select taxa either promote or delay transplant rejection.

PI_NAMEs: ALEGRE, MARIA-LUISA  (contact)

PROGRAM_OFFICER_NAME: KEHN, PATRICIA J

PROJECT_TERMS: Acceleration;Affect;allograft rejection;Allografting;Animals;Antibiotics;Bacteria;Bacteroides thetaiotaomicron;Cell Physiology;Clinical;clinically relevant;Collection;Data;Dendritic Cells;Disparity;Distal;draining lymph node;engineered T cells;Etiology;experimental study;fecal microbiome;fecal microbiota;Feces;Funding;Genetic;genetic signature;germ free condition;Germ-Free;Gnotobiotic;Graft Rejection;Graft Survival;gut colonization;gut microbiota;Half-Life;Heart;heart allograft;Heart Transplantation;host colonization;Immune;Immune response;Immune system;Immunosuppression;Immunosuppressive Agents;improved;Individual;Individual Differences;insight;Interferons;Intervention;Intestines;isoimmunity;Kidney Transplantation;Kinetics;Location;Lung;Lung Transplantation;MHC Class II Genes;Microbe;microbial;microbial community;microbiota;migration;Minor;Mus;novel;Organ;Organ Donor;Organ Transplantation;Outcome;pharmacologic;Phase;prebiotics;Probiotics;Proliferating;reconstitution;response;Role;side effect;Site;Skin;skin allograft;Skin colonization;Skin graft;Skin Transplantation;Small Intestines;Staphylococcus aureus;Staphylococcus epidermidis;Sterility;Stomach;synergism;System;T-Lymphocyte;Therapeutic;Tissue Donors;Tissues;Transplantation

PROJECT_TITLE: Impact of Microbiota on Alloimmune Responses in Transplantation

STUDY_SECTION: TTT

STUDY_SECTION_NAME: Transplantation, Tolerance, and Tumor Immunology Study Section[TTT]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: Project Narrative Accurate chromosome segregation critically depends on the effective attachment between kinetochores of the chromosomes and microtubules of the mitotic spindle. Defective kinetochore-microtubule attachments lead to chromosome mis-segregation and aneuploidy. Our work will examine new mechanisms that control kinetochore- microtubule attachments to prevent chromosome mis-segregation. Our long-term goal is to understand how defects in these mechanisms lead to the biogenesis and progression of cancer generated by aneupoidy.

PI_NAMEs: VARMA, DILEEP  (contact)

PROGRAM_OFFICER_NAME: MILLER, RITA K

PROJECT_TERMS: Aneuploidy;aurora B kinase;Binding;Binding Proteins;Binding Sites;Biogenesis;Biological Models;cell assembly;Cellular Structures;Centromere;chromosome conformation capture;chromosome missegregation;Chromosome Segregation;Chromosomes;Complex;Data;daughter cell;Defect;Distal;Dynein ATPase;Goals;Human;Individual;Kinetochores;Lateral;Lead;Mediating;Metaphase;Microtubule Stabilization;Microtubule-Associated Proteins;Microtubules;Mitosis;Mitotic;Mitotic spindle;Molecular;Motor;Multiprotein Complexes;N-terminal;novel;Pathway interactions;Phosphorylation;Phosphotransferases;prevent;Process;Prometaphase;protein function;Proteins;Publishing;recruit;Regulation;Replication Licensing;Role;segregation;Sister;Site;Slide;synergism;Testing;tumor progression;Work

PROJECT_TITLE: Molecular mechanisms controlling kinetochore-microtubule attachments during mitosis

STUDY_SECTION: NCSD

STUDY_SECTION_NAME: Nuclear and Cytoplasmic Structure/Function and Dynamics Study Section[NCSD]


NIH_SPENDING_CATS: Hematology;Rare Diseases

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE Colony stimulating factor 3 receptor (CSF3R) is the primary regulator of neutrophil production. Mutations in CSF3R are associated with poor-prognosis myeloproliferative neoplasms. This proposal investigates a novel mechanism of CSF3R-driven MAPK pathway activation and its role in the biogenesis of myeloproliferative neoplasms.

PI_NAMEs: MANIACI, BREANNA NICOLE (contact)

PROJECT_TERMS: Adaptor Signaling Protein;Automobile Driving;Biogenesis;Biology;Biotinylation;Bone Marrow Transplantation;career;Cell Line;Cell surface;Cells;Colony Stimulating Factor Activation;cost;Cytoplasm;Cytoplasmic Tail;Data;design;Development;Disease;Disease Progression;drug development;Equilibrium;experimental study;extracellular;Fellowship;Flow Cytometry;Genetic Transcription;granulocyte;Granulocyte Colony-Stimulating Factor Receptors;Granulopoiesis;Growth;Growth Factor Receptors;Hematological Disease;Hematology;Hematopoiesis;Hematopoietic;In Vitro;in vivo;in vivo Model;insight;knock-down;Knowledge;Ligand Binding;Link;Maintenance;MAP Kinase Gene;MAPK Signaling Pathway Pathway;MAPK3 gene;Maps;Marrow;Mass Spectrum Analysis;Mediating;Mentors;Monitor;mouse model;Mus;mutant;Mutate;Mutation;Myelogenous;Myeloid Cells;Myeloproliferative disease;National Research Service Awards;Neoplasms;neutrophil;new therapeutic target;novel;overexpression;Pathway interactions;Phenylalanine;Phosphorylation;Phosphotransferases;Play;Point Mutation;precursor cell;Production;Prognosis;programs;Proliferating;protein protein interaction;receptor;Receptor Activation;Receptor Signaling;Recurrence;Regulation;RIPK3 gene;Role;Signal Pathway;Signal Transduction;skills;small hairpin RNA;Stains;STAT3 gene;Surface;targeted treatment;Testing;transcriptome sequencing;transcriptomics;Tyrosine;Western Blotting;Work

PROJECT_TITLE: The role of NCK1 in CSF3R-driven myeloproliferative neoplasms


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: EMORY UNIVERSITY

PHR: PROJECT NARRATIVE The proposed project seeks to adapt and pilot test an intervention to build resilience among young Black gay, bisexual and other men who have sex with men (YB-GBMSM) who are living with HIV. This intervention is designed to improve young men’s perceptions of their own identities, while also enhancing social connections and ultimately improving engagement in care. This project is relevant to public health because YB-GBMSM are disproportionately impacted by HIV, but face many barriers to care.

PI_NAMEs: HUSSEN, SOPHIA A. (contact)

PROGRAM_OFFICER_NAME: KAMATH, SUSANNAH M A

PROJECT_TERMS: acceptability and feasibility;Address;Age;Area;barrier to care;behavior change;Belief;Bisexual;Black race;Brothers;Buffers;care outcomes;Caring;Clinical;Collaborations;Communities;community based participatory research;community organizations;community partners;Consolidated Framework for Implementation Research;Continuity of Patient Care;Control Groups;County;design;Development;Discrimination;Disparity;Disparity population;disparity reduction;effectiveness/implementation trial;efficacy trial;Epidemic;Evaluation;evidence base;Evidence based intervention;Face;Future;Gays;Geography;Goals;HIV;HIV disparities;HIV/AIDS;Home;homonegativity;improved;Incidence;Individual;Institution;Intervention;intervention effect;Intervention Studies;Lead;medication compliance;men;men who have sex with men;Methods;Morbidity - disease rate;mortality;multidisciplinary;NIH Office of AIDS Research;novel;online resource;Outcome;Perception;Persons;pilot test;pilot trial;Positioning Attribute;Prevalence;Prevention Research;Process;process improvement;promote resilience;psychosocial;Public Health;Race;racism;Randomized;Randomized, Controlled Trials;recruit;Research;Research Methodology;resilience;resilience factor;Resources;Safety;satisfaction;Series;Sexuality;Site;social;social capital;Social Environment;Social Network;social stigma;Structural Racism;Structure;Sum;telehealth;Testing;theories;therapy design;Translating;transmission process;United States National Institutes of Health;videoconference;Viral;Waiting Lists;Work;young man;Youth

PROJECT_TITLE: Brothers building brothers by breaking barriers (B6): A resilience-focused intervention for young Black gay and bisexual men living with HIV

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


NIH_SPENDING_CATS: Cancer;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Genetics;Prevention;Rare Diseases

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: NARRATIVE. For a cell to become cancerous, it must reprogram its metabolism in order to fuel unrestrained growth and progression to metastasis. Head and neck cancer is one of the most common cancers – with low survival and treatment regimens that can leave patients (sometimes quite young) disfigured and unable to swallow or speak. As experts on a human protein known as “DEK,” we have performed experiments that strongly suggest that DEK controls metabolic reprogramming in order to promote cancer development and metastatic dissemination. The proposed studies will determine whether this is the case, while also revealing and testing new metabolism-based strategies for head and neck cancer prevention and treatment.

PI_NAMEs: WELLS, SUSANNE I (contact)

PROGRAM_OFFICER_NAME: WILLIS, KRISTINE AMALEE

PROJECT_TERMS: 3-Dimensional;aerobic glycolysis;Alanine;beta catenin;Binding Proteins;Biochemical;Biochemical Pathway;Bioenergetics;Biological Markers;biomarker identification;biomarker validation;Breast Cancer Cell;cancer cell;Cancer Cell Growth;cancer type;Cancerous;Cell Nucleus;Cell Proliferation;cell transformation;cell type;Cells;Cholesterol;cholesterol biosynthesis;Cholesterol Homeostasis;Chromatin;Citric Acid Cycle;Confocal Microscopy;Coupled;Data;Deglutition;DEK gene;Development;diagnostic biomarker;drinking;Drug Targeting;Early Diagnosis;Early identification;Energy Supply;Enzyme Activation;enzyme biosynthesis;Enzymes;Epidermis;Epithelium;experimental study;extend lifespan;Fermentation;Fibroblasts;Fractionation;gain of function;Genetic Transcription;Genus Hippocampus;Glucose;Glycolysis;Growth;Head and Neck Cancer;head and neck cancer prevention;Head and Neck Squamous Cell Carcinoma;HPV-negative head and neck cancer;Human;Human Activities;human model;Human papilloma virus infection;Hyperplasia;improved outcome;inhibitor;innovation;Intervention;Invaded;keratinocyte;knock-down;Knock-out;Laboratories;leukemia;Literature;loss of function;macromolecule;Malignant Neoplasms;Maps;Mass Spectrum Analysis;Messenger RNA;Metabolic;Metabolic Control;Metabolic Pathway;Metabolism;metabolomics;Mitochondria;Modeling;Molecular;mutant;Neoplasm Metastasis;Neoplastic Cell Transformation;new therapeutic target;Normal Cell;novel;Nuclear;Nuclear Pore Complex Proteins;nucleic acid binding protein;Oncogenes;Oncogenic;oral HPV-positive head and neck cancers;Outcome;overexpression;Oxidative Phosphorylation;Pathway interactions;Patients;Phenotype;prevent;Prevention strategy;Process;Production;programs;Proliferating;protein expression;Proteins;reconstitution;Reporting;Resolution;Role;Signal Transduction;Smoking;Source;Specimen;stable isotope;targeted biomarker;Technology;Testing;Therapeutic;three-dimensional modeling;Time;transcriptome sequencing;Treatment Protocols;treatment strategy;tumor;tumor growth;tumor progression;Tumor Promotion;tumorigenesis;Xenograft procedure

PROJECT_TITLE: New activities of the human DEK oncogene

STUDY_SECTION: CPSS

STUDY_SECTION_NAME: Cancer Prevention Study Section[CPSS]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_CITY: CAMBRIDGE

ORG_DEPT: BIOLOGY

ORG_NAME: HARVARD UNIVERSITY

PHR: PROJECT NARRATIVE The neural basis of learning is complex, which likely involves the activities of many brain areas whose malfunctions are associated with impaired learning ability in various neurological diseases that adversely affect communication. This project studies how learning is encoded by the dynamic activity of the nervous system at the scale of whole brain with the resolution of individual neurons. The outcome of the proposed study will contribute to our integrative understanding of how learning is regulated by the brain function across scales, inform learning studies in more complex brains, and guide potential design of therapeutic strategies.

PI_NAMEs: LU, HANG ;ZHANG, YUN  (contact)

PROGRAM_OFFICER_NAME: BABCOCK, DEBRA J

PROJECT_TERMS: Acute;Address;Affect;Anatomy;Animal Model;Animals;Area;Behavior;behavior test;Behavioral;Biochemical;Brain;Brain imaging;Brain region;Caenorhabditis elegans;Cells;Characteristics;Communication;Complex;connectome;Data;Defect;design;Development;Dimensions;Engineering;Exhibits;experience;Food;Foundations;Genetic;Genetic Identity;genetic makeup;Glean;Goals;Head;Human;Image;Impairment;in vivo calcium imaging;Individual;innovation;insight;Interneurons;Intervention;Invertebrates;learned behavior;Learning;learning ability;learning engagement;Learning Module;Maps;Measures;Methods;Mission;Modeling;Molecular;Molecular Genetics;Nematoda;Nervous System;Nervous System Disorder;Nervous System Physiology;neural;neuron component;Neurons;Neurosciences;Olfactory Learning;Optics;Organism;Outcome;pathogenic bacteria;Pattern;Play;prevent;Process;Property;Psychophysics;Regulation;Research;Resolution;Role;Sensory;sensory input;Sensory Process;Smell Perception;spatiotemporal;Structure;System;Systems Analysis;Taste Perception;Techniques;temporal measurement;Testing;Therapeutic;therapy design;Time;tool;Training;Work

PROJECT_TITLE: Functional Analysis of Whole-Brain Dynamics in Learning

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


NIH_SPENDING_CATS: Autism;Brain Disorders;Clinical Research;Genetic Testing;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric;Prevention

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE This study focuses on two genetic risk factors of autism—structural variation and ultra-rare, single-nucleotide mutation—to pinpoint likely disease-causing genes. We will test the significance of rare, gene-disruptive mutations by examining large numbers of families with autism and discover more complex variants by applying cutting-edge sequencing technologies. We will select a subset of genes and families for clinical follow-up to determine if carriers manifest more subtle features and whether the mutations are necessary and sufficient to cause disease.

PI_NAMEs: EICHLER, EVAN  (contact)

PROGRAM_OFFICER_NAME: PEVSNER, JONATHAN ABRAM

PROJECT_TERMS: Affect;Age;autism spectrum disorder;Candidate Disease Gene;Child;Clinical;Clinical assessments;clinical diagnostics;cohort;Complex;Copy Number Polymorphism;Data;de novo mutation;Detection;detection sensitivity;Disease;dosage;Etiology;Event;Exclusion;exome;exome sequencing;Family;Family history of;Female;follow-up;Future;Gene Mutation;Genes;Genetic;genetic architecture;genetic disorder diagnosis;Genetic Models;Genetic Predisposition to Disease;Genetic Risk;genetic risk factor;genetic variant;Genetic Variation;Genome;genome sequencing;Genomics;Genotype;Goals;Hereditary Disease;Individual;Inheritance Patterns;Inherited;insight;interest;Large-Scale Sequencing;loss of function mutation;Maps;Methods;Micro Array Data;Missense Mutation;Modeling;Morbidity - disease rate;Mutation;neuropsychiatry;novel;Nucleotides;Parents;Pathogenicity;Pathway interactions;Patients;Penetrance;Phenotype;Point Mutation;Population Control;Privatization;proband;rare variant;Recontacts;Recurrence;research clinical testing;Resolution;Risk;Risk Factors;risk variant;Sample Size;Sampling;sequencing platform;Single Nucleotide Polymorphism;Technology;Testing;Therapeutic;transmission process;Validation;Variant;variant detection;whole genome;Whole-Genome Shotgun Sequencing;Work

PROJECT_TITLE: Rare Mutations and Autism Spectrum Disorders

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]