ORG_DEPT: CHEMISTRY

PHR: PROJECT NARRATIVE The UCLA Cell and Molecular Biology (CMB) Training Program endeavors to train and prepare the next generation of diverse cell and molecular biology PhD students for biomedical careers. The underpinnings of the CMB Training Program come from the interdisciplinary state-of-the-art research training in cellular and molecular biology provided by the CMB student-centered curriculum, structured-activities, and faculty mentors. Additionally, the CMB Training Program provides training in resilience, skill development, and career development, while supporting trainees through mentoring and cohort-building activities.

PI_NAMEs: TORRES, JORGE  (contact)

PROGRAM_OFFICER_NAME: AIYEGBO, MOHAMMED S

PROJECT_TERMS: Cellular biology;Molecular Biology;Research Training

PROJECT_TITLE: Research Training in Cell and Molecular Biology

STUDY_SECTION_NAME: Training and Workforce Development Study Section - A[TWD-A]


ADMINISTERING_IC: DA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Mental Health;Neurosciences;Substance Misuse

ORG_CITY: SAINT LOUIS

ORG_COUNTRY: UNITED STATES

ORG_DEPT: NEUROSCIENCES

ORG_FIPS: US

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Economic choice is the behavior observed when individuals choose between multiple available options based on subjective preference -- for example out of a restaurant menu. It is specifically impaired in various clinical conditions including schizophrenia and drug addiction. The overarching goal is to dissect the neural circuit underlying economic decisions using genetic tools in mice. 1

PI_NAMEs: PADOA-SCHIOPPA, CAMILLO  (contact)

PROGRAM_OFFICER_NAME: MOORE, HOLLY MARIE

PROJECT_TERMS: Address;Anatomy;Animals;Anterior;Area;Behavior;Brain;Brain region;Calcium;calcium indicator;cell type;Cells;Choice Behavior;Clinical;Clinical Data;Collaborations;Computer Models;Contralateral;Corpus striatum structure;Data;Decision Making;Disease;Dorsal;Drug Addiction;Economic Models;Economics;Etiology;experimental study;Fluorescence;Frontotemporal Dementia;Functional Imaging;Genetic;Genetic Markers;Goals;Head;Human;Image;Impairment;Individual;Interneurons;Investigation;Juice;Lateral;lens;Lesion;Link;Liquid substance;Major Depressive Disorder;Medial;Mental disorders;Monkeys;Motor;mouse model;Mus;Nervous System Disorder;neural;neural circuit;Neurons;neurophysiology;nonhuman primate;olfactory stimulus;optical imaging;optogenetics;Output;Parvalbumins;piriform cortex;Play;Population;preference;Preparation;Primates;Procedures;Process;Protocols documentation;Publishing;Pyramidal Cells;Reporting;Research;Restaurants;Rewards;Role;Schizophrenia;Sensory;sensory input;Series;Serotonin;Side;Signal Transduction;Smell Perception;Somatostatin;Subcellular Anatomy;success;Synapses;Testing;Time;tool;two-photon;Viral;Virus;With laterality;Work

PROJECT_TITLE: Mechanisms of Economic Decisions in Mice

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


ADMINISTERING_IC: HL

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Congenital Structural Anomalies;Genetics;Lung;Pediatric;Rare Diseases

ORG_CITY: ATHENS

ORG_NAME: UNIVERSITY OF GEORGIA

ORG_STATE: GA

PHR: Elastic microfibrils are what give lungs and other tissues elasticity and recoil and are essential for their development and function. We have recently identified two novel enzymes (POGLUT2 and POGLUT3) that add glucose to the major structural protein of microfibrils called Fibrillin, and mice lacking these enzymes die shortly after birth with lung defects. The studies described here investigate why addition of glucose to Fibrillin1 (and related proteins) is important for proper lung function.

PI_NAMEs: HALTIWANGER, ROBERT S. (contact);HOLDENER, BERNADETTE C

PROGRAM_OFFICER_NAME: LIN, SARA

PROJECT_TERMS: Address;Affect;Affinity;Alanine;Amino Acids;Aorta;autosome;Binding;Binding Proteins;Binding Sites;Biological Assay;Birth;Bone Growth;Calcium;Calcium Binding;Cell Differentiation process;Cells;Cessation of life;Consensus;Consensus Sequence;Cysteine;Data;Databases;Defect;Deposition;Dermal;Development;Disease;Dissection;Elastic Tissue;Elasticity;Elastin;Electron Microscopy;Endoplasmic Reticulum;Ensure;Enzymes;Epidermal Growth Factor;Extracellular Matrix;Eye;FBN1;fibrillin;fibrillin-2;Fibroblasts;Genetic;Glucose;Glucosyltransferases;glycoproteomics;glycosylation;Heart;Histologic;Homeostasis;Human;Impairment;In Vitro;in vitro Assay;in vivo;Knock-out;Knockout Mice;Label;Ligand Binding;Ligands;Link;Location;Lung;lung development;Marfan Syndrome;Mediating;Methods;Microfibrils;Modification;Molecular;mouse model;Mus;mutant;Mutate;Mutation;N-terminal;notch protein;novel;Patients;Peptide Hydrolases;Perinatal;Perinatal mortality demographics;Phenotype;Play;protein function;Protein Secretion;Proteins;pulmonary function;Recombinants;response;Role;scaffold;Serine;Signal Transduction;Site;Structural defect;Structural Protein;Structure;Survivors;Syndactyly;Tensile Strength;Testing;Tissues;trafficking;Transforming Growth Factor beta

PROJECT_TITLE: Role of POGLUT2 and POGLUT3 in regulating microfibril structure and function

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-H(80)S]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases;Influenza;Lung;Lymphatic Research;Pneumonia and Influenza

ORG_CITY: BOSTON

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

ORG_STATE: MA

PHR: PROJECT NARRATIVE The overall goal of our grant is to understand the basic biology of cells that line the lung’s lymphatic system. These cells are termed lymphatic endothelial cells and to date, very little is known regarding the origin of these as new lymphatics arise in adult life and whether these cells represent a homogeneous population or a set of cell subtypes each with distinct functions in health and diseases, in particular infections. Our hope is that these studies will provide important information that can be used to develop new and effective treatment strategies for respiratory viral infections.

PI_NAMEs: FINE, ALAN FINE (contact);JONES, MATTHEW ROBERT

PROJECT_TERMS: Acute;Address;Adult;Alleles;Anatomy;Attenuated;biological systems;Biology;Blood Vessels;Cell Count;Cell Line;Cell Nucleus;Cell Proliferation;Cells;Cellular biology;Contralateral;Cre lox recombination system;Data;Deoxyuridine;Derivation procedure;Disease;Distal;effective therapy;experimental study;fetal;flu;Fluid Balance;Gases;Genetic Engineering;genetic information;Genetic Transcription;Goals;Grant;Health;Heart;Heterogeneity;Homeobox;Homeostasis;Immune;immune function;Immune response;Infection;Inflammation;Influenza;influenza infection;insight;Knowledge;Label;Left;Life;Liver;Lobe;Location;Lung;lung health;lung lobe;Lymphangiogenesis;Lymphatic;Lymphatic Endothelial Cells;Lymphatic System;mechanical signal;Messenger RNA;Microanatomy;Modeling;Molecular Analysis;Mus;Myelogenous;Nuclear;Nuclear Protein;Nuclear RNA;Pathway interactions;Phase;Phenotype;Physiological;Play;Population;postnatal;Process;Proliferating;Property;protein expression;pulmonary function;Reaction;Regulation;response;RNA;Role;Signal Pathway;Signal Transduction;single nucleus RNA-sequencing;Site;Source;System;Systems Biology;Time;tissue injury;Tissues;trafficking;transcription factor;transcriptome sequencing;treatment strategy;Venous;Viral;Viral Load result;Viral Respiratory Tract Infection;Virus

PROJECT_TITLE: Biology of Lymphangiogenesis in the Adult Lung

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


ADMINISTERING_IC: NR

ED_INST_TYPE: SCHOOLS OF NURSING

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Autoimmune Disease;Behavioral and Social Science;Clinical Research;Digestive Diseases;Inflammatory Bowel Disease;Neurosciences;Sleep Research;Social Determinants of Health

ORG_CITY: SEATTLE

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE This proposed study provides information on the influence of sleep-wake cycles on Inflammatory Bowel Disease (IBD), a chronic autoimmune disease, that impacts the quality of life of an estimated 3 million Americans. The proposed study presents insights on the social and societal factors that impact sleep-wake cycles of those with IBD as well as the relationships between 24-hour rest-activity rhythms and social jetlag with IBD health outcomes, such as fatigue, and disease activity. The findings from this project will assist in future research on interventions that promote stable sleep-wake cycles for persons with IBD.

PI_NAMEs: YOO, LINDA  (contact)

PROGRAM_OFFICER_NAME: HUSS, KAREN

PROJECT_TERMS: Abdominal Pain;actigraphy;Address;Adult;Adverse effects;American;Animal Model;Animals;Arousal;Award;Behavior;behavior influence;Behavior Therapy;Biologic Characteristic;Biological;Biological Markers;care costs;Characteristics;Chronic;chronic autoimmune disease;Circadian Dysregulation;circadian pacemaker;Circadian Rhythms;Clinic;Constipation;Crohn's disease;Data;design;Development;diaries;Diarrhea;Disease;Disease Outcome;Disease remission;doctoral student;dysbiosis;Electronics;Environment;experience;Family;Fatigue;Fellowship;Financial Hardship;Functional disorder;Gases;Gastroenterology;Gastrointestinal Diseases;gastrointestinal symptom;gastrointestinal system;Genetic;Goals;gut dysbiosis;Health;Healthcare;Hospitalization;Hour;Human;improved;Individual;Individual National Research Service Award;Inflammatory;Inflammatory Bowel Diseases;insight;Intervention;Interview;intestinal barrier;Intestines;Investigation;Jet Lag Syndrome;Knowledge;Lead;lens;Leukocyte L1 Antigen Complex;Life;Life Style;Link;Measurement;Measures;Medical center;Metabolic;Methods;minority patient;Minority Status;Modeling;mortality;Nausea;Nursing Research;Outcome;Participant;Patients;Persons;Pittsburgh Sleep Quality Index;Population;pre-doctoral;Prevalence;Principal Investigator;Productivity;programs;Progressive Disease;prospective;Qualitative Methods;Quality of life;Questionnaires;recruit;Reporting;Research;Research Personnel;Research Project Grants;Research Training;Rest;Risk;Role;Sampling;Schedule;Schools;Self Management;skills;Sleep;Sleep Disorders;Sleep disturbances;Sleep Fragmentations;sleep quality;Sleep Wake Cycle;social;social factors;social health determinants;Societal Factors;stool sample;Structure;symptom science;Symptoms;System;Testing;Time;Training;Ulcerative Colitis;United States;Universities;Washington;Work;Wrist

PROJECT_TITLE: Sleep-Wake Cycles of Individuals with Inflammatory Bowel Disease

STUDY_SECTION: NRRC

STUDY_SECTION_NAME: Nursing Science Review Committee[NRRC(84)]


ADMINISTERING_IC: DK

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative This program trains physician-scientists and postdoctoral scientists in many areas of endocrinology research. The major themes are the hormonal regulation of metabolism and energy balance as well as the development and regulation of endocrine glands, hormone production, and endocrine tumors. Our mission is to prepare the next generation of academic endocrinologists and selected PhD scientists for successful careers in basic, translational, and patient-oriented research in endocrinology.

PI_NAMEs: AUCHUS, RICHARD J. (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Endocrinology;Training Programs

PROJECT_TITLE: Training Program in Endocrinology and Metabolism

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

ORG_STATE: CA

PHR: This grant will support a program at UC Davis that will provide pre-doctoral cross training at the chemistry/biology interface. Program activities will prepare students for careers in the biomedical workforce where they can effectively communicate and direct research programs that integrate approaches across these two disciplines.

PI_NAMEs: BEAL, PETER A. (contact)

PROGRAM_OFFICER_NAME: HARTON, MARIE DEBORAHGAYNELLE

PROJECT_TERMS: Biology;Chemicals;programs

PROJECT_TITLE: UC Davis Chemical Biology Program

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - B[TWD-B]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Anxiety Disorders;Brain Disorders;Genetics;Human Genome;Mental Health;Mental Illness;Neurosciences;Post-Traumatic Stress Disorder (PTSD)

ORG_CITY: ATLANTA

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: EMORY UNIVERSITY

PHR: Narrative Multiple studies report DNA methylation differences that distinguish PTSD cases from symptom-free controls after exposure to a traumatic event. The purpose of this study is to identify replicable patterns of DNA methylation that associate with PTSD, characterize cross-tissue similarities between blood and brain, and determine the degree to which these patterns change in response to effective PTSD treatment.

PI_NAMEs: LOGUE, MARK W;NIEVERGELT, CAROLINE M;SMITH, ALICIA K (contact);UDDIN, MONICA

PROGRAM_OFFICER_NAME: PRICE, AMANDA JOY

PROJECT_TERMS: Acceleration;Age;Autopsy;Bioinformatics;Biological;Biological Markers;bisulfite;Blood;Brain;Brain region;brain tissue;Cells;Clinical;cohort;Collaborations;Complement;Country;Data;DNA analysis;DNA Methylation;Ensure;Environmental Exposure;epigenetic marker;Epigenetic Process;epigenome-wide association studies;Exhibits;Exposure to;Freezing;Genes;Genetic;genetic variant;genome-wide;Genotype;insight;Longitudinal Studies;Measures;Mendelian randomization;Meta-Analysis;Methylation;methylation pattern;methylome;Military Personnel;Neuroglia;Neurons;Paper;Pathway interactions;Patients;Pattern;pediatric trauma;Peripheral;Persons;Post-Traumatic Stress Disorders;Productivity;prospective;Prospective Studies;psychiatric genomics;Quantitative Trait Loci;Reporting;Reproducibility;Research Personnel;resilience;responders and non-responders;response;risk mitigation;risk prediction;Role;Sampling;Severities;Signal Transduction;Site;Sorting;stress related disorder;Symptoms;Testing;therapeutic target;therapy development;Tissues;Trauma;trauma exposure;traumatic event;traumatic stress;treatment response;whole genome;Work

PROJECT_TITLE: The Impact of Traumatic Stress on the Methylome: implications for PTSD

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-K(02)]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Immunization;Immunotherapy;Orphan Drug;Ovarian Cancer;Prevention;Rare Diseases;Vaccine Related;Women's Health Research

ORG_CITY: JACKSONVILLE

ORG_NAME: MAYO CLINIC  JACKSONVILLE

ORG_STATE: FL

PHR: PROJECT NARRATIVE This project will evaluate the clinical efficacy and mechanism of action of a novel Th17-inducing vaccine in combination with pembrolizumab in the setting of disease recurrence in ovarian cancer patients. The overall goal is development of a vaccine to eradicate recurrent disease and death in ovarian cancer.

PI_NAMEs: BLOCK, MATTHEW STEPHEN;KNUTSON, KEITH L. (contact)

PROGRAM_OFFICER_NAME: SONG, MIN-KYUNG H

PROJECT_TERMS: Adaptive Immune System;Address;Adverse event;analytical tool;Antibodies;Antibody Activation;antibody-dependent cell cytotoxicity;Antigens;B-Lymphocytes;bevacizumab;biomarker identification;Cancer Etiology;cancer infiltrating T cells;Cancer Patient;Cellular Immunity;Cessation of life;Characteristics;Clinical;Clinical effectiveness;clinical efficacy;clinical outcome assessment;Combined Modality Therapy;Combined Vaccines;Data;dendritic cell vaccination;Dendritic Cell Vaccine;Dendritic Cells;Development;Disease Progression;Disease remission;eosinophil;Epithelial ovarian cancer;Evaluable Disease;follow-up;FOLR1 gene;Funding;Goals;Grant;Human;Humoral Immunities;Hyperthermia;IL17 gene;immune checkpoint;immune checkpoint blockade;Immune response;Immune system;Immunity;Immunologic Tests;Immunosuppression;improved;Innate Immune System;Interleukin-15;intraperitoneal therapy;Macrophage;Malignant neoplasm of ovary;Malignant Neoplasms;Mitogen-Activated Protein Kinase Inhibitor;mouse model;Mus;Mutation;Myelogenous;Neoadjuvant Therapy;neoantigens;novel;objective response rate;Outcome;Outcome Measure;ovarian neoplasm;p38 Mitogen Activated Protein Kinase;Pathologic;Patient-Focused Outcomes;Patients;pembrolizumab;Phagocytes;Phase;Phase I Clinical Trials;Phase I/II Clinical Trial;Phenotype;Poly(ADP-ribose) Polymerase Inhibitor;pre-clinical;preclinical study;prevent;primary outcome;Production;profiles in patients;prognostic value;programmed cell death ligand 1;programs;recruit;Recurrence;Recurrent disease;Regulatory T-Lymphocyte;Resistance;resistance mechanism;response;response biomarker;Safety;standard of care;success;T cell infiltration;T-Lymphocyte;therapeutically effective;Therapeutically Targetable;therapy design;therapy resistant;Time;Tissues;trafficking;treatment response;tumor;tumor microenvironment;tumor progression;tumor-immune system interactions;Vaccinated;Vaccination;vaccine development;Vaccines;Woman;Work

PROJECT_TITLE: A phase I/II study of combined therapy with Th17-inducing dendritic cells and pembrolizumab in patients with recurrent epithelial ovarian cancer

STUDY_SECTION: CONC

STUDY_SECTION_NAME: Clinical Oncology Study Section[CONC]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Neurosciences;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: PROJECT NARRATIVE GBM is the most aggressive primary brain tumor with a two-year survival rate of less than 50% following surgical resection, radiation and chemotherapy. It is characterized by extensive hypoxia-induced, mitochondria-dependent phenotypic changes such as a glycolytic respiration, decreased ability to undergo apoptosis and extensive invasiveness which are linked to GBM's resistance to radiation and chemotherapy. Mitochondrial LonP1 is an ATP-stimulated protease, directly up-regulated by HIF-1α. LonP1 is overexpressed in human malignant gliomas and its elevated expression levels are associated with high glioma tumor grade and poor patient survival. Therefore, regulation of mitochondrial function by inhibiting LonP1 protease could represent a novel approach for GBM and potentially other fast-growing malignancies which heavily depend on hypoxic adaptation. The proposed project is based on our preliminary results obtained from in vitro (cell-based) studies with our LonP1 inhibitor compound BT317 and in vivo LonP1-overexpression xenograft models studies. BT317 is a small molecule compound and highly effective against multiple GBM cell lines – identifying BT317 as a potentially new therapy for this universally fatal disease.

PI_NAMEs: BOTA, DANIELA ANNENELIE (contact);DAS, BHASKAR CHANDRA

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: Adult;Animal Model;anti-cancer;Apoptosis;Automobile Driving;Binding;Biochemical;Bioenergetics;Biogenesis;Biological;Biology;blood-brain barrier crossing;Brain;Brain Neoplasms;Cell Culture Techniques;Cell Cycle;Cell Death Induction;Cell Line;Cell Survival;Cells;Cervical;chemotherapeutic agent;chemotherapy;Chemotherapy and/or radiation;clinical application;Clinical Trials;Colorectal;CRISPR/Cas technology;Cues;cytotoxic;Development;Disease;DNA biosynthesis;Drug Targeting;endopeptidase La;epithelial to mesenchymal transition;Equilibrium;Excision;FDA approved;gene therapy;Glioblastoma;Glioma;glioma cell line;Goals;Growth;Heat shock proteins;Homeostasis;Human;Hypoxia;Immunodeficient Mouse;In Vitro;in vivo;in vivo Model;Inbred BALB C Mice;inhibitor;interest;knock-down;Knock-out;Lead;Libraries;Link;Malignant Glioma;Malignant Neoplasms;Maximum Tolerated Dose;Measures;Melanoma;Mesenchymal;Metabolic;meter;Mitochondria;Mitochondrial DNA;mitochondrial DNA mutation;mitochondrial dysfunction;mitochondrial metabolism;Mitochondrial Proteins;Modeling;Molecular;Molecular Chaperones;Neoplasm Metastasis;Normal Cell;novel;novel strategies;novel therapeutics;nutrient deprivation;Operative Surgical Procedures;Oral;overexpression;Pathway interactions;Patients;Peptide Hydrolases;pharmacologic;Phenotype;Primary Brain Neoplasms;Process;Prognosis;Prognostic Factor;protein degradation;Proteins;Publishing;Radiation therapy;Recurrence;Recurrent tumor;Regulation;Resistance;Respiration;response;RNA;Role;Small Interfering RNA;small molecule;stable cell line;standard of care;stem cells;stem-like cell;Structure-Activity Relationship;Study models;Survival Rate;synergism;System;temozolomide;Testing;Therapeutic;therapy resistant;Toxic effect;tumor;tumor growth;tumor initiation;Up-Regulation;Xenograft Model

PROJECT_TITLE: Targeting of Mitochondrial Lon Protease as a Novel Therapy for Glioblastoma

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


FUNDING_MECHANISM: RESEARCH CENTERS

PHR: The UC Davis Comprehensive Cancer Center discovers new knowledge that leverages and translates the best of UC Davis science to generate innovation and impact on its catchment area and beyond. The Center takes advantage of a cadre of cancer-focused investigators and unique resources to address the cancer burden through cutting-edge research, community outreach and engagement, clinical trials, and education/training of the next generation of cancer investigators. The Center works collaboratively and purposefully to improve the lives and well-being of people with cancer or at risk of developing cancer.

PI_NAMEs: LARA, PRIMO N. (contact)

PROGRAM_OFFICER_NAME: ROBERSON, SONYA

PROJECT_TERMS: Address;Affect;agricultural region;Agriculture;Antineoplastic Agents;Area;authority;Behavior;Biological Sciences;Biomedical Engineering;Businesses;California;Cancer Biology;Cancer Burden;cancer care;Cancer Center Support Grant;Cancer Control;cancer education;cancer health disparity;Cancer Model;cancer research center director;cancer risk;career development;Catchment Area;Center Core Grants;Cities;Clinical;Clinical Services;Clinical Trials;Communities;community engagement;Community Outreach;comparative;Comprehensive Cancer Center;Country;County;Diagnostic;Disadvantaged;Discipline;Disease;disparity reduction;Distributed Systems;DNA Repair;Early Diagnosis;early phase clinical trial;Education;Engineering;Enrollment;Environmental Science;Funding;Geographic Locations;Grant;Health;Health behavior;Health Sciences;Home;Human;Image;Imaging Device;Immunology;improved;innovation;Institution;Intervention;invention;investigator-initiated trial;Journals;Knowledge;Leadership;Malignant Neoplasms;Medical center;Medical Imaging;medical schools;member;Metabolism;Microscopic;Mission;Molecular;NCI-Designated Cancer Center;new technology;next generation;novel;Oncology;outreach;Palpable;Patients;Personal Satisfaction;Persons;Population;Positioning Attribute;Positron-Emission Tomography;prevent;Productivity;programs;Publications;Publishing;Radio;Recording of previous events;Research;Research Personnel;Resource Sharing;Resources;Risk;risk mitigation;rural area;School Nursing;Science;Scientist;Screening for cancer;screening guidelines;Secure;Signal Transduction;Solid;Techniques;Technology;Time;tobacco control;Training;Training and Education;Translating;treatment trial;tumor;United States National Institutes of Health;Universities;Veterinary Medicine;Veterinary Schools;Vision;Vulnerable Populations;Work;Workforce Development

PROJECT_TITLE: Cancer Center Support Grant P30


NIH_SPENDING_CATS: Cancer

PI_NAMEs: DAYTON, GINA M (contact)

PROJECT_TERMS: Address;Cancer Burden;Cancer Center;Cancer Center Support Grant;career development;Catchment Area;Center Core Grants;Clinical;Clinical Research;Collaborations;Communication;community engagement;Community Outreach;Comprehensive Cancer Center;Development;Education;Ensure;Fostering;Foundations;Funding;Goals;Growth;Guidelines;Information Technology;Infrastructure;Institution;Leadership;Malignant Neoplasms;Mission;Occupational activity of managing finances;operation;Organization administrative structures;Population Research;Positioning Attribute;Process;Productivity;programs;Research;Resource Allocation;Resource Sharing;Resources;Strategic Planning;Training;Universities;Vision

PROJECT_TITLE: Cancer Center Administration


ORG_DEPT: NEUROSURGERY

PHR: Overall: Project Narrative The overarching theme of this Program Project Proposal, submitted by the Park-Reeves Chiari & Syringomyelia Center at Washington University, is “Redefining Chiari Type I Malformation and its Impact on Brain Development.” This program will leverage leading edge imaging, genomics, and the largest and most refined cohort of Chiari I malformation patients in the world to determine the relationships between the dynamic pathophysiology at the interface of the cerebellum, brainstem, and spinal cord and brain development, neurological outcome, and quality of life. A novel data-driven framework for Chiari I malformation will be created to enhance treatment response, minimize complications, and maximize neurological outcomes and quality of life.

PI_NAMEs: LIMBRICK, DAVID DELMAR;LU, CHENYANG  (contact)

PROGRAM_OFFICER_NAME: RIDDLE, ROBERT D

PROJECT_TERMS: Address;Affect;behavioral outcome;Biological;Brain;Brain Stem;Cerebellar tonsil;Cerebellum;Clinical;clinical practice;Cognition;Cognitive;cohort;Complex;Data;Data Set;deep learning;Development;Diagnosis;Dimensions;endophenotype;Environment;Etiology;experience;Experimental Models;Expert Opinion;foramen magnum;Functional disorder;Funding;Genetic;genetic variant;Genomics;Genotype;Image;Impairment;improved;Incidental Discoveries;Individual;Injury;International;Investigation;Lead;Magnetic Resonance Imaging;malformation;Maps;Mediating;Methods;Motion;multidimensional data;Nervous System Physiology;neurobehavioral;Neurologic Deficit;Neurologic Effect;Neurological outcome;novel;Outcome;Pain;pain-related disability;Participant;Pathologic;Pathology;Pathway interactions;Patient-Focused Outcomes;Patients;Pattern;Phenotype;Population;Posterior Fossa;Precision therapeutics;predictive modeling;programs;Quality of life;Radiology Specialty;Randomized, Controlled Trials;Research;Scheme;Scientific Advances and Accomplishments;skull base;Spinal Cord;Sum;synergism;Syringomyelia;Tonsil;translational genomics;translational neuroscience;Treatment outcome;treatment response;Universities;Variant;Vertebral column;Washington;Work


NIH_SPENDING_CATS: Congenital Structural Anomalies;Neurosciences;Pediatric;Rare Diseases

PI_NAMEs: LIMBRICK, DAVID DELMAR (contact)

PROJECT_TERMS: Achievement;Advisory Committees;Arbitration;Area;Binding;Biological;Brain;Budgets;Charge;Clinical;Communication;Communities;conflict resolution;Consensus;Data;data access;data sharing;Department chair;Development;Doctor of Medicine;Doctor of Philosophy;Education;Ensure;Event;Funding;Future;Genetic;Goals;Grant;Growth;Guidelines;Human Subject Research;Individual;innovation;Institution;interest;International;Investigation;Lead;Leadership;malformation;meetings;Methods;Mission;Monitor;neurobehavioral;Neurologic;Neurology;neurosurgery;Outcome;Output;Patient-Focused Outcomes;Patients;Performance;Practice Management;Process;Productivity;Progress Reports;psychologic;Quality of life;Radiology Specialty;Reporting;Research;Research Institute;Research Personnel;Resources;Review Committee;Sampling;Schedule;Science;Strategic Planning;Structure;success;synergism;Syringomyelia;Time;Trust;United States National Institutes of Health;Universities;Update;Washington

PROJECT_TITLE: Admin Core


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Congenital Structural Anomalies;Genetics;Human Genome;Neurosciences;Pediatric;Rare Diseases

PI_NAMEs: CRUCHAGA, CARLOS  (contact)

PROJECT_TERMS: Back;Biocompatible Materials;Bioinformatics;Biological Assay;Biological databases;biomarker signature;Blood specimen;Brain;Clinical;Clinical/Radiologic;Collection;Communication;Communities;Complex;Data;Data Analyses;data repository;Data Set;data sharing;Data Storage and Retrieval;data submission;Databases;Dedications;design;Development;DNA;DNA Library;endophenotype;Ensure;exome sequencing;experimental study;Feedback;follow-up;Functional disorder;Future;Genes;Genetic;Genetic Databases;genetic information;genetic variant;Genetic Variation;genome wide association study;genomic data;Genomics;Genotype;Goals;Human Genetics;Human Resources;Image;improved;Link;malformation;Measurement;Measures;meetings;Neurological outcome;next generation sequencing;novel;Operative Surgical Procedures;Outcome;Participant;Pathologic;Patients;Phenotype;phenotypic data;Policies;precision medicine;Procedures;Process;Qualifying;Quality Control;Quality of life;Radiogenomics;Radiology Specialty;repository;Research;Research Personnel;Risk;Saliva;Secure;Specimen;Standardization;Statistical Data Interpretation;Syringomyelia;trait;United States National Institutes of Health;user-friendly;Variant;web site;web-based tool;Work

PROJECT_TITLE: Genetics Core


PI_NAMEs: MEYERS, FREDERICK J. (contact)

PROJECT_TERMS: Academy;Accountability;anti-cancer research;Award;Basic Science;Cancer Center;Cancer Center Support Grant;cancer education;Cancer Science;career;career development;Center Core Grants;Clinical Research;Collaborations;Communication;Communities;community engagement;comparative;Comprehensive Cancer Center;Country;curriculum development;Data Science;Databases;Development;disability;Disadvantaged;Diverse Workforce;Education;Educational workshop;Evaluation;Extramural Activities;Faculty;Fostering;Funding;Future;Future Generations;Grant;Healthcare Systems;Hearing;high school;High School Faculty;improved;innovation;Institution;Laboratories;Leadership;lectures;Malignant Neoplasms;member;Mentors;Mentorship;Multilingualism;NCI Center for Cancer Research;next generation;Oncology;organizational structure;Pathway interactions;Persons;Postdoctoral Fellow;Process;Program Evaluation;programs;recruit;Research;Resource Sharing;Resources;Schools;Science;skills;Strategic Planning;success;Supervision;The Jackson Laboratory;Training;Training Activity;Training and Education;training opportunity;Training Programs;Translational Research;undergraduate student;United States National Institutes of Health;Universities;Vision;Voice;Wages;web site;Work;Workforce Development

PROJECT_TITLE: Cancer Research Training and Education Coordination


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: CHICAGO

ORG_DEPT: DERMATOLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative Technological innovation has dramatically improved our understanding of skin biology and skin disease. To effectively harness such knowledge and bring it to the bedside, there is a dramatic need for well-trained skin- focused physician-scientists and PhD scientists. The Northwestern Postgraduate Training Program in Cutaneous Biology provides a mechanism to address this critical need by nurturing the next generation of leaders in dermatology and skin biology/engineering.

PI_NAMEs: PALLER, AMY S (contact)

PROGRAM_OFFICER_NAME: VINCENT, ISAAH S

PROJECT_TERMS: Biology;Cutaneous;programs

PROJECT_TITLE: Post Graduate Program in Cutaneous Biology


PI_NAMEs: HEYER, WOLF-DIETRICH  (contact)

PROJECT_TERMS: Acceleration;Address;anti-cancer research;Area;Award;base;Basic Cancer Research;Basic Science;Behavior;Biochemistry;Biological Models;Biology;Cancer Biology;Cancer Burden;Cancer Center Support Grant;cancer recurrence;Cancer Science;Catchment Area;Center Core Grants;Chromosomes;Clinic;Clinical Investigator;Clinical Trials;Collaborations;college;Communities;Comprehensive Cancer Center;Critical Pathways;design;Development;Direct Costs;Doctor of Philosophy;Fostering;Funding;Genetic;Genome Stability;Genomics;Goals;Hormone Receptor;Individual;innovation;Institution;Journals;Laboratories;Leadership;Malignant Neoplasms;member;Metabolism;Mission;Molecular;Molecular and Cellular Biology;molecular oncology;Neoplasm Metastasis;new technology;next generation;novel;oncology program;Pathologist;Pathway interactions;Peer Review;Pilot Projects;Pre-Clinical Model;preclinical study;prevent;Productivity;programs;Publications;Publishing;recruit;Research;Research Personnel;Resource Sharing;Resources;Role;Schools;Scientist;Signal Transduction;Strategic Planning;Therapeutic;Training;Translating;translational impact;translational pipeline

PROJECT_TITLE: Molecular Oncology Program


PROJECT_TERMS: Adolescent;aged;Brain;Cervical;Clinic;Clinical;Clinical Data;clinical database;clinical practice;Code;cognitive development;cohort;Cohort Studies;Collaborations;Communities;comorbidity;Consent;Data;Data Set;Databases;design;Development;Diffusion Magnetic Resonance Imaging;disease natural history;Elements;eligible participant;Enrollment;follow up assessment;follow-up;follower of religion Jewish;Fostering;Foundations;Genetic;Genetic Databases;Goals;health related quality of life;Hospitals;Individual;innovation;instrument;International;Investigation;Lead;Leadership;Longterm Follow-up;malformation;Mission;neurobehavioral;Neurological outcome;Outcome Measure;Participant;Patient advocacy;Patient Outcomes Assessments;Patient-Focused Outcomes;Patients;Pediatric Hospitals;Posterior Fossa;Predictive Value;Procedures;Process;Prospective cohort;Quality Control;Radiology Specialty;randomized, clinical trials;recruit;Registries;Reproducibility;Research;Research Personnel;Research Priority;Resources;Scientific Advances and Accomplishments;Scientific Inquiry;Scientist;screening;Services;Site;Spinal Cord Diseases;Support Groups;Syringomyelia;Telephone;treatment and outcome;United States National Institutes of Health;Universities;video visit;Washington

PROJECT_TITLE: Clinical Core


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Project Narrative Up to 65% of adults age 65 and over will lose their ability to independently ambulate during their hospital stay, creating a substantial public health concern due to significant declines in older adult functional status, increased burden on caregivers, decreased quality of life, and major increases in costs to the healthcare system. Limited patient ambulation is the norm of care for older adults during hospital stay and is directly related to the loss of independent ambulation that occurs in hospital settings. To address this problem, our proposal will test an innovative model of care, which will improve independent ambulation of older adults both during hospital stay and post discharge, improve healthcare utilization post discharge, and identify ongoing barriers that may impact translation of the intervention across different hospital systems.

PI_NAMEs: KING, BARBARA  (contact);STEEGE, LINSEY M

PROGRAM_OFFICER_NAME: IGNACZAK, AARTEE

PROJECT_TITLE: Preventing Hospital-Acquired Disability: An Intervention to Improve Older Adult Patient Ambulation

STUDY_SECTION: HSQR

STUDY_SECTION_NAME: Healthcare Patient Safety and Quality Improvement Research[HSQR]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Congenital Structural Anomalies;Neurosciences;Pediatric;Rare Diseases

PI_NAMEs: SHIMONY, JOSHUA S (contact)

PROJECT_TERMS: Adherence;Anatomy;Archives;Board Certification;Brain;Calibration;career development;Clinical;clinical center;clinical imaging;Code;Cohort Studies;Complex;Computer software;computerized data processing;Data;data access;data acquisition;data archive;Data Set;Databases;Development;Diameter;Diffusion;Documentation;early-career faculty;Elements;Ensure;follow-up;Functional Magnetic Resonance Imaging;Funding;Future;Genetic;Goals;Grant;Horns;Human;Human Resources;Image;image archival system;imaging science;Individual;innovation;Interdisciplinary Study;Length;Magnetic Resonance Imaging;malformation;Measurement;Measures;member;Methods;Mission;MRI Scans;neural network;neuroimaging;Neurological outcome;Outcome Measure;Output;Participant;Pathway Analysis;Patient Outcomes Assessments;Pediatric Hospitals;Performance;Phenotype;Population;Positioning Attribute;Procedures;Process;Protocol Compliance;Protocols documentation;Quality Control;radiological imaging;Radiology Specialty;repository;Reproducibility;Research;Research Personnel;research study;Rest;Scanning;Schedule;Secure;Services;Side;Site;spectrograph;Spinal Cord;Standardization;Stream;Structure;Syringomyelia;Testing;Tonsil;translational scientist;Universities;Vertebral column;Washington;Work

PROJECT_TITLE: Radiology Core


NIH_SPENDING_CATS: Cancer;Immunotherapy;Prevention

PI_NAMEs: CHEN, XINBIN  (contact)

PROJECT_TERMS: Acceleration;Address;Animal Model;Animals;anti-cancer research;Area;Basic Science;Biological Models;Biology;Cancer Burden;Cancer Center Support Grant;Cancer Diagnostics;Cancer Patient;cancer therapy;Canis familiaris;Catchment Area;Center Core Grants;Clinical;Clinical Investigator;Collaborations;college;companion animal;comparative;Comprehensive Cancer Center;Development;Direct Costs;Early Intervention;first-in-human;Fostering;Funding;Genetic;Genetic Engineering;Genetic Induction;Goals;Human;Immunologics;Immunology;Immunotherapy;In Vitro;Individual;innovation;insight;Institution;Investigation;Journals;Knowledge;Leadership;Malignant Neoplasms;member;Metabolic;Mission;Molecular;Mus;Neoplasm Metastasis;Neoplastic Processes;new technology;next generation;novel;Oncogenic Viruses;Oncology;oncology program;Patient-Focused Outcomes;Peer Review;Pilot Projects;pre-clinical;Pre-Clinical Model;preclinical trial;prevent;Productivity;programs;Proto-Oncogenes;Publications;Publishing;Reporting;Research;Research Personnel;Resource Sharing;Resources;Risk;Schools;Science;Scientist;Signal Pathway;Signal Transduction;Therapeutic;Training;Training Programs;Translating;translational pipeline;Translational Research;Translations;Tumor Biology;tumor heterogeneity;tumor initiation;tumor microenvironment;Tumor Suppressor Genes;Veterinarians;Viral Oncogene

PROJECT_TITLE: Comparative Oncology Program


ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE Distinct fibroblast subsets are critical regulators of tissue homeostasis and tissue repair. Although recent discoveries have highlighted the diversity of fibroblast subsets within different tissues, it remains unclear how upstream signals trigger fibroblast activation and how this activity regulates tissue immunity. The research program supported by this funding, will investigate the molecular mechanisms of fibroblast activation and how intercellular signaling controls wound healing and tissue immunity in the pulmonary alveolus.

PI_NAMEs: ZEPP, JAROD  (contact)

PROGRAM_OFFICER_NAME: CHAO, CHIEN-CHUNG

PROJECT_TERMS: Allergens;anti-microbial drug;Cells;Chemicals;Epithelial Cells;epithelial stem cell;Exposure to;Fibroblasts;Foundations;Funding;Future;Genetic;Goals;Homeostasis;Human;Immune;Immunity;immunological status;in vivo Model;Inflammation;Inflammatory Response;influenza infection;Inhalation;Injury;injury and repair;insight;Length;Lung;Lung Diseases;lung injury;lung repair;Mediating;Mesenchyme;Modeling;Molecular;mouse model;Mucous body substance;novel;Organ;Organoids;Outcome;Particulate;Pathway interactions;Program Description;programs;Pulmonary alveolar structure;Research;Resolution;Respiration Disorders;respiratory pathogen;response;Sentinel;Shapes;Signal Transduction;Smooth Muscle;Testing;tissue repair;Tissues;wound healing

PROJECT_TITLE: Lung repair mechanisms mediated by the immune-fibroblast interface

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


NIH_SPENDING_CATS: Congenital Structural Anomalies;Genetics;Neurosciences;Pediatric;Rare Diseases

PI_NAMEs: HALLER, GABRIEL E (contact)

PROJECT_TERMS: 3-Dimensional;accurate diagnosis;Affect;Animal Model;Bioinformatics;Biological;Body System;Brain;brain overgrowth;Brain Stem;brain volume;Cerebellar tonsil;Cerebellum;Cerebrospinal Fluid;cerebrospinal fluid flow;Cerebrospinal fluid shunts procedure;Childhood;Classification;Clinical;Clinical Treatment;cohort;Collaborations;comorbidity;Complex;Craniosynostosis;cranium;Cyst;Data;Data Set;de novo mutation;Development;Disease;Disparate;Engineering;Etiology;exome sequencing;Fishes;foramen magnum;gene discovery;Genes;Genetic;Genetic Models;genetic risk factor;genetic variant;Genetic Variation;genome wide association study;Genotype;Goals;Head circumference;hindbrain;Human;Hydrocephalus;imaging biomarker;Individual;insight;Knock-out;Lead;Liquid substance;Macrocephaly;Magnetic Resonance Imaging;malformation;Measurement;Methods;Microsurgery;Modeling;Mutation;Natural History;Neurologic;Neurologic Symptoms;Neurosurgeon;neurosurgery;NF1 gene;Obstruction;Operative Surgical Procedures;Outcome;Pathology;Pathway interactions;Patients;Phenotype;Physiology;Positioning Attribute;Predictive Factor;Proteins;Radiology Specialty;rare variant;repaired;Risk;Role;Severities;Skeletal system;Spinal Canal;Spinal Fusion;Spine surgery;Stents;Syringomyelia;System;Testing;Time;Tonsil;trait;Variant;venous sinus;ventricular system;Vertebral column;Zebrafish

PROJECT_TITLE: Genetic Underpinnings of CM and SM and Effect on Brain Development


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Diabetes;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: Nashville

ORG_DEPT: PHARMACOLOGY

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: PROJECT NARRATIVE Diabetic retinopathy, the leading cause of blindness in working-age Americans, currently lacks therapies that target early stages of disease before severe damage to the retina has occurred. NSAID drugs such as ibuprofen have exhibited some capacity to limit the retinal inflammation that occurs early in diabetic retinopathy, but chronic use of these drugs can cause severe side effects that outweigh any benefits. I propose to identify the specific receptor(s) of prostanoids, the lipid signaling molecules downstream of NSAID targets, that can be inhibited by small molecules to prevent inflammation in the retina, identifying a novel therapeutic option for diabetic retinopathy that acts before vision loss begins.

PI_NAMEs: STARK, AMY KATHRYN (contact)

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: Address;Adhesions;Age;American;Animals;antagonist;Anti-Inflammatory Agents;Biological Assay;Blindness;blood damage;Blood Glucose;Blood Vessels;Cardiovascular system;Cell Adhesion Molecules;cell behavior;cell injury;Cells;Chronic;Clinical Trials;Complications of Diabetes Mellitus;cytokine;Cytokine Gene;Data;Diabetes Mellitus;diabetic;Diabetic Angiopathies;Diabetic mouse;Diabetic Retinopathy;Dinoprostone;Disease;Dose;Drug Targeting;Drug usage;Dyslipidemias;Early Intervention;Electroretinography;Endothelial Cells;Endothelium;Environment;Enzymes;Event;Exhibits;Experimental Models;Functional disorder;gastrointestinal;Gene Expression;Generations;Glucose;Goals;Homeostasis;Human;Ibuprofen;ICAM1 gene;immune cell infiltrate;Impairment;In Vitro;in vivo;Individual;Inflammation;Inflammatory;Interleukin-1 beta;Laboratories;Leukocytes;Leukostasis;Lipids;Mass Spectrum Analysis;Measures;Mentors;Molecular Target;mouse model;Muller's cell;Mus;Non-Steroidal Anti-Inflammatory Agents;Nonesterified Fatty Acids;novel therapeutic intervention;novel therapeutics;pain reduction;Palmitic Acids;Pathogenicity;Pathology;Pathway interactions;Pharmaceutical Preparations;Pharmacotherapy;pre-clinical assessment;preclinical efficacy;Prevalence;prevent;Production;Prostaglandin-Endoperoxide Synthase;Prostaglandins;receptor;Recording of previous events;Research;Retina;retina blood vessel structure;retinal damage;Scientist;SELE gene;side effect;Signal Pathway;Signal Transduction;Signaling Molecule;small molecule;Stains;Stimulus;Streptozocin;targeted treatment;Testing;Therapeutic;therapeutic evaluation;Therapeutic Intervention;therapeutic target;Time;Tissues;Training;Treatment Efficacy;Triglycerides;Universities;Vascular Endothelial Cell;vascular inflammation;Vision research;Visual impairment;Work

PROJECT_TITLE: Targeted prostanoid inhibition as an anti-inflammatory therapy for diabetic retinopathy


NIH_SPENDING_CATS: Bioengineering

ORG_CITY: UNIVERSITY PARK

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

PHR: Project Narrative Non-heme-iron and 2-oxo-glutarate-dependent enzymes perform an incredible array of oxidative transformations in biosynthetic pathways of medicinal natural products. This project seeks to understand which structural factors allow the metallocofactor in these enzymes to perform various reactions. Uncovering this knowledge will unlock the opportunities for bioengineering these enzymes for novel drug synthesis and develop innovative bio-inspired chemical processes.

PI_NAMEs: SILAKOV, ALEXEY  (contact)

PROGRAM_OFFICER_NAME: SIMONOVIC, MILJAN

PROJECT_TERMS: Address;adduct;alpha ketoglutarate;analog;Anions;Architecture;Azides;Binding;Biomedical Engineering;C-terminal;Carbon;Cell Nucleus;Chemicals;cofactor;Complex;Coupling;Cyclization;Data;dehydrogenation;Drug Industry;drug synthesis;Electrons;Enzymes;experimental study;Family;ferryl iron;Frequencies;geometric structure;Geometry;Glutarates;halogenation;Halogens;Hydrogen Bonding;Hydroxylation;Implant;Individual;innovation;insight;Iron;Isomerism;Isotopes;Kinetics;Knowledge;Letters;Ligands;Location;Magnetism;Maps;Measures;Mediating;Medicine;member;Membrane Proteins;Metals;Methodology;Methods;Mixed Function Oxygenases;Natural Product Drug;Natural Products;neurotensin mimic 2;nitroxyl;novel;novel therapeutics;orientation selectivity;Outcome;oxidation;Oxygen;Oxygenases;Pathway interactions;Phenotype;Positioning Attribute;preference;Process;Proteins;Reaction;Role;Site;Spectroscopy, Fourier Transform Infrared;Spectrum Analysis;structural determinants;Structure;Synthesis Chemistry;synthetic drug;System;Vanadyl;Variant;Work;X-Ray Crystallography

PROJECT_TITLE: The role of geometric structure in avoidance of oxygen rebound to enable aliphatic halogenation and oxacyclization by non-heme Fe(IV)-oxo (ferryl) complexes


PI_NAMEs: LAM, KIT S (contact)

PROJECT_TERMS: Acceleration;anti-cancer research;Antineoplastic Agents;Award;Basic Science;Biological;Biological Markers;Biomedical Engineering;Cancer Center;Cancer Center Support Grant;Catchment Area;Center Core Grants;Clinical;Clinical Investigator;Clinical Research;clinical translation;Clinical Trials;Clinical Trials Network;college;Comprehensive Cancer Center;design;Development;Direct Costs;Doctor of Philosophy;Drug Delivery Systems;drug development;drug discovery;Early Therapeutic-Clinical Trials Network;Education and Outreach;experience;Faculty;Funding;Galectin 1;Grant;high school;Human;Immunotherapeutic agent;Industry;Infusion procedures;inhibitor;innovation;Institution;Intervention;intravital microscope;Journals;KRAS2 gene;Lead;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Mediating;member;Mentored Clinical Scientist Development Program;Mentors;Mission;Modality;molecular marker;Molecular Target;multidisciplinary;Mutate;nano;Nature;New Agents;next generation;novel;novel anticancer drug;novel imaging technique;Paper;Patient Care;patient oriented;Patients;Peer Review;Peptides;Physicians;Pilot Projects;pre-clinical;pre-clinical research;Process;Productivity;programs;Publishing;receptor;Reporting;Research;research and development;Research Personnel;Research Project Grants;Resource Sharing;RNA;Schools;Science;Scientist;Technology;Therapeutic;therapeutic target;tool;Training;Translating;translational physician;translational scientist;translational study;Translations;treatment trial

PROJECT_TITLE: Cancer Therapeutics Program


NIH_SPENDING_CATS: Neurosciences;Nutrition;Obesity

ORG_CITY: NEW YORK

ORG_DEPT: PHYSIOLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: To understand the etiology of metabolic disorders and motivated behavior it is essential that we gain better insight into the neuronal circuitry related to metabolism and behavior. We propose studies that will define and assess the role of subpopulations of melanocortin 4 receptors neurons of the Dorsal Raphe Nucleus in the regulation of energy homeostasis. The proposed studies are a logical continuation of our ongoing studies and, if successful, their completion will unmask a novel mechanistic principle in central regulation of systemic metabolism.

PI_NAMEs: DIANO, SABRINA  (contact)

PROGRAM_OFFICER_NAME: COOKE, BRAD

PROJECT_TERMS: Action Potentials;Affect;Agreement;Anatomy;Bathing;Behavior;Behavioral;Body Weight decreased;Brain Stem;Cell Nucleus;cell type;Data;designer receptors exclusively activated by designer drugs;Development;diet-induced obesity;Dopamine;Dorsal;dorsal raphe nucleus;Emotional Stress;Energy Metabolism;Etiology;experimental study;Fasting;feeding;Fiber;Food Intake Regulation;Frequencies;gamma-Aminobutyric Acid;Genetic Models;Glutamates;Homeostasis;Hypothalamic structure;immunoreactivity;Induced Neurons;Injections;insight;Lateral;Ligands;Melanocortin 4 Receptor;Metabolic Diseases;Metabolism;Midbrain structure;Molecular;Moods;motivated behavior;Mus;Nature;neuronal circuitry;Neurons;novel;Obese Mice;obesity development;pharmacologic;Phenotype;Play;postsynaptic;presynaptic;Process;Publishing;reduced food intake;Regulation;Reporting;Role;Serotonin;Signal Pathway;Signal Transduction;Slice;Thermogenesis;Weight Gain;α-Melanocyte stimulating hormone

PROJECT_TITLE: Dorsal raphe nucleus melanocortin signaling regulates energy homeostasis

STUDY_SECTION: POMD

STUDY_SECTION_NAME: Pathophysiology of Obesity and Metabolic Disease Study Section[POMD]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Autoimmune Disease;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Inflammatory Bowel Disease;Machine Learning and Artificial Intelligence;Neurosciences;Prevention

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: There are not effective strategies to identify or predict flares of ulcerative colitis (UC), which are common and result in morbidity. We aim to identify and modify readily obtainable physiological metrics, focusing on autonomic nervous system function, to recognize flares early, predict their development and improve symptomatology. This will improve management of UC, its associated morbidity, and disease outcomes.

PI_NAMEs: HIRTEN, ROBERT  (contact)

PROGRAM_OFFICER_NAME: OSGANIAN, VOULA

PROJECT_TERMS: Abdominal Cramps;Abdominal Pain;Affect;American;Apple watch;Area;Autonomic nervous system;Award;Behavior Therapy;Biofeedback;biomarker development;Blood;career;career development;chronic inflammatory disease;clinical care;Clinical Trials;Clinical Trials Design;cohort;Collection;Colon;Country;Data;Data Science;Defecation;Development;Diarrhea;digital;Digital biomarker;digital health;digital platform;digital technology;Disease;Disease Outcome;Disease remission;disorder control;Early identification;Engineering;Enrollment;Environment;Evaluation;experience;Feces;Flare;Funding;Future;Gastroenterology;Goals;Grant;heart rate variability;Hospitals;Impairment;improved;indexing;Individual;Individual Differences;Inflammation;Inflammatory Bowel Diseases;inflammatory marker;innovation;Institution;International;Intervention;Leukocyte L1 Antigen Complex;Link;Longitudinal cohort study;Machine Learning;Maps;Measurement;Measures;medical schools;Mentorship;Methodology;Methods;mobile application;model development;Modeling;Monitor;Morbidity - disease rate;Nervous System Physiology;news;novel;Participant;Patient Compliance;patient oriented;Patient Recruitments;Patients;Performance;personalized approach;Physicians;Physiologic Monitoring;Physiological;Positioning Attribute;predictive modeling;Predisposition;prevent;Prevention approach;prospective;Prospective cohort;Protocols documentation;Quality of life;Rectum;Reporting;Research;Research Personnel;Resource Allocation;Science;Scientist;skill acquisition;skills;smartphone application;Standardization;Statistical Data Interpretation;Surveys;symptomatic improvement;symptomatology;Symptoms;Techniques;Testing;Time;Training;Training Activity;Ulcerative Colitis;United States National Institutes of Health;wearable device;wearable sensor technology;Work

PROJECT_TITLE: Digital Biomarkers of Ulcerative Colitis Flare

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Mental Health;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIVERSITY OF CHICAGO

PHR: We will conduct a Hybrid Type II effectiveness-implementation randomized controlled trial of a Case Management Dyad (CM2) intervention, an evidence-based triadic social work intervention that uses a case manager dyad to engage younger Black sexual minority men (YBSMM) aged 18-35 in economic stability services. If successful, CM2 will intensify existing case management resource support systems, which will not only impact the lives and care continua of YBSMM, but also fulfill an ending the epidemic priority of revitalizing and sustaining the HIV frontline workforce.

PI_NAMEs: BOURIS, ALIDA M;SCHNEIDER, JOHN  (contact)

PROGRAM_OFFICER_NAME: POLLARD-BRANCHARD, SUZANNE LEE

PROJECT_TERMS: Accountability;Address;Adoption;aged;Attention;Black race;burnout;Caring;Case Management;Case Manager;Client;Climate;community engagement;Computerized Medical Record;Consolidated Framework for Implementation Research;Consultations;Consumption;Contact Tracing;Continuity of Patient Care;cost;Counseling;COVID-19;Data;Data Collection;design;Development;Documentation;Economics;Effectiveness;effectiveness evaluation;effectiveness testing;effectiveness-implementation RCT;Employment;Epidemic;Evaluation;Event;evidence base;experience;Food;food security;Health Insurance;Healthcare;HIV;Housing;Human;hybrid type 2 trial;Hybrids;implementation evaluation;implementation framework;implementation outcomes;implementation strategy;improved;Individual;Infrastructure;innovation;integrated care;Intervention;Intuition;Job Satisfaction;Maintenance;Mediating;member;Mental Health;Methods;Modeling;Morale;Outcome;Participant;Personal Satisfaction;pre-exposure prophylaxis;prevent;Prevention;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Reporting;Resources;Services;sexual minority men;Shelter facility;skills;Social Work;Structure;substance use;Supervision;Support System;Supported Employment;Surveys;System;Testing;Time;Trainers Training;Training;transmission process;Violence;Viral Load result;Vulnerable Populations;Work

PROJECT_TITLE: Implementation of a triadic network case management intervention for younger Black sexual minority men

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


ORG_NAME: WASHINGTON UNIVERSITY

PHR: The rapid advances in biomedical research in recent decades has resulted in a critical need for physicians who are well-trained investigators to work at the intersection of clinical medicine and laboratory science to develop innovative approaches for the diagnosis and treatment of disability and disease. The goal of the Medical Scientist Training Program at Washington University in St. Louis is to identify, train, and mentor a diverse group of outstanding scholars to become the future leaders in biomedical research, patient care and academic medicine.

PI_NAMEs: YOKOYAMA, WAYNE M. (contact)

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TERMS: Medical;National Research Service Awards;Scientist

PROJECT_TITLE: National Research Service Award-Medical Scientist


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Congenital Structural Anomalies;Neurosciences;Pediatric

PI_NAMEs: ROLAND, JAROD  (contact)

PROJECT_TERMS: Adolescent;Adult;Age;anatomic imaging;Anatomy;Anisotropy;arm;Attention;attentional control;behavior measurement;behavior test;behavioral phenotyping;Brain;Brain Stem;Cerebellar tonsil;Cerebellum;Cerebrum;Child;Child Behavior Checklist;Childhood;Clinical;Clinical Treatment;Cognition;Cognitive;cognitive development;cognitive function;cognitive testing;cohort;Data;Data Set;Development;Diffusion Magnetic Resonance Imaging;Disease;Disease Outcome;emotion regulation;Emotional;emotional symptom;Emotions;Executive Dysfunction;executive function;foramen magnum;Frequencies;Functional disorder;Functional Magnetic Resonance Imaging;Headache;Health;Image;imaging biomarker;Impaired cognition;improved;indexing;Individual;internal control;Intervention;longitudinal analysis;Longitudinal Studies;Magnetic Resonance Imaging;malformation;Maps;Measures;Moods;motor control;Needles;Neurobehavioral Manifestations;neuroimaging;novel;Operative Surgical Procedures;Outcome;outcome prediction;Paresthesia;Participant;Pathologic;Pathology;Pathway interactions;Patients;Pediatric cohort;Pediatrics;Pontine structure;Positioning Attribute;Posterior Fossa;predictive marker;Protocols documentation;Radiology Specialty;response;Rest;Role;Sampling;Scanning;Severities;sham surgery;Short-Term Memory;Signs and Symptoms;Site;Spinal Canal;Spinal Cord;Standardization;Surgical Decompression;symptomatic improvement;Symptoms;Testing;Time;Tonsil;treatment and outcome;United States National Institutes of Health;Work

PROJECT_TITLE: Functional Connectivity, Brain Development, and Outcomes in Chiari Type I Malformation


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Comparative Effectiveness Research;Cost Effectiveness Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Social Determinants of Health

ORG_CITY: MINNEAPOLIS

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE The introduction of generic dolutegravir (DTG) to resource-limited settings (RLS) raises new questions about optimum clinical management for people living with HIV for whom DTG-based regimens are failing. Conducting further clinical research can inform and improve HIV treatment guidelines; however, research funding resources are limited. This project aims to use innovative value of information analysis methods to efficiently inform the prioritization and design of potential clinical research studies related to managing virologic failure on DTG-based ART for adults (15 years and older) in Kenya, which will also have broader implications for RLS.

PI_NAMEs: DUARTE, HORACIO ADRIAN (contact)

PROGRAM_OFFICER_NAME: HUEBNER, ROBIN E

PROJECT_TERMS: Accounting;Adherence;Adolescent and Young Adult;Adult;Affect;Africa South of the Sahara;antiretroviral therapy;Bayesian Analysis;Bayesian Modeling;Calibration;career development;Caring;Childhood;Clinical;Clinical Management;Clinical Research;Collaborations;Communicable Diseases;Computing Methodologies;cost;cost effective;cost effectiveness;Cost Effectiveness Analysis;Data;data visualization;Decision Analysis;Decision Making;design;Diagnosis;Drug resistance;Economic Models;Environment;Epidemiology;Failure;Funding;Future;global health;Goals;Grant;Guidelines;Health;Health Benefit;health economics;Health Policy;High Prevalence;HIV;improved;Individual;innovation;insight;Institution;Investments;Kenya;Learning;mathematical model;Methodology;Methods;model development;Modeling;models and simulation;NNRTI-resistance;Nucleosides;older adult;open source;Outcome;Output;Patients;Persons;Policies;Population;Positioning Attribute;Protease Inhibitor;Recommendation;Recording of previous events;Regimen;Research;Research Design;Research Project Grants;research study;Resistance;Resource-limited setting;Resources;Reverse Transcriptase Inhibitors;Sample Size;Sampling;Statistical Methods;Statistical Models;Testing;theories;Training;treatment guidelines;Uncertainty;Universities;Update;Viral;Viral Load result;Visualization software;Washington;Work;World Health

PROJECT_TITLE: Value of Information and Cost-Effectiveness Analysis to Optimize Research and Policy Decisions for HIV Care in Resource Limited Settings

STUDY_SECTION: AIDS

STUDY_SECTION_NAME: Acquired Immunodeficiency Syndrome Research Study Section[AIDS]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention

PI_NAMEs: MARCU, LAURA  (contact)

PROJECT_TERMS: Acceleration;Address;Advanced Development;anti-cancer research;Area;Artificial Intelligence;Beds;Biomedical Engineering;Biomedical Technology;Biophotonics;Cancer Burden;Cancer Center;Cancer Center Support Grant;Cancer Detection;Cancer Diagnostics;cancer imaging;cancer therapy;Catchment Area;Center Core Grants;Clinical;clinical application;clinical implementation;Clinical Investigator;clinical translation;Clinical Trials;Collaborations;college;commercialization;Comprehensive Cancer Center;Computing Methodologies;Development;Diagnosis;Diagnostic;Diagnostic radiologic examination;diagnostic tool;Direct Costs;Doctor of Philosophy;Engineering;Ensure;fluorescence lifetime imaging;Funding;Goals;Image;imaging agent;Imaging technology;improved;Individual;Institution;Journals;Leadership;Malignant Neoplasms;Measures;medical schools;member;Microscopic;Mission;Molecular;molecular imaging;Morbidity - disease rate;mortality;neural network;new technology;next generation;novel;Optics;Peer Review;Pilot Projects;Positron-Emission Tomography;prevent;Productivity;programs;Publications;Publishing;Radiology Specialty;Radiopharmaceuticals;Reporting;Research;research clinical testing;Research Personnel;Research Project Grants;Resource Sharing;Resources;Schools;Science;Scientist;Series;Techniques;Technology;technology development;theranostics;Therapeutic;Tissues;Training;Translating;translational applications;translational pipeline;Translations;Universities;Veterinary Medicine;Veterinary Schools

PROJECT_TITLE: Biomedical Technology Program


NIH_SPENDING_CATS: Bioengineering;Nanotechnology

ORG_CITY: ITHACA

ORG_NAME: CORNELL UNIVERSITY

PHR: Project Narrative  Fluorine is a ubiquitous element in active pharmaceuticals, but its controlled installation presents a significant challenge due to the volatile reactivity of many fluorinating agents. This proposal aims to tackle this challenge by a completely new, multidisciplinary approach that borrows from materials science, namely, to stabilize reactive fluorinated species in porous, sponge-like materials and deliver them on demand. The success of the proposed research will open up new avenues in the synthesis of biologically active molecules and, more broadly, demonstrate the unrealized potential of porous materials in medicine and human health.

PI_NAMEs: MILNER, PHILLIP JOHN (contact)

PROGRAM_OFFICER_NAME: ASLAN, KADIR

PROJECT_TITLE: Taming Fluorine: Metal-Organic Frameworks for the Heterogeneous Delivery of Fluorinated Building Blocks

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-P(55)R]


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Neurosciences;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_DEPT: BIOLOGY

ORG_NAME: COLUMBIA UNIV NEW YORK MORNINGSIDE

PHR: PROJECT NARRATIVE Salamanders are the closest relatives to humans that are capable of regenerating complex body parts, such as the brain and entire limbs; however, the underlying molecular and cellular mechanisms remain poorly understood. An intact nervous system is essential for regeneration, and in this project we will compare the nerve dependency of regeneration in different body parts, to identify conserved mechanisms. This research will reveal generalizable principles of regeneration, that may inform the development of new approaches for human regenerative medicine

PI_NAMEs: TOSCHES, MARIA ANTONIETTA (contact)

PROGRAM_OFFICER_NAME: SALAZAR, DESIREE LYNN

PROJECT_TERMS: Adult;Ambystoma;Amphibia;Anatomy;Animals;Behavior;Biological Metamorphosis;Biology;Body part;Brain;Cell Communication;cell type;Cells;Comparative Study;Complement;Complex;Dependence;Development;Environment;Evolution;Foundations;Gene Transfer Techniques;Genes;Genome;genome editing;Goals;Human;Life;Life Cycle Stages;limb regeneration;Limb structure;Link;Mediating;Methods;Molecular;Natural regeneration;Nerve;Nervous System;neural;neurotransmission;Newts;novel strategies;Organ;Pathology;Physiological;Physiology;Pleurodeles;programs;Property;Protein Secretion;regeneration model;regenerative;Regenerative capacity;Regenerative Medicine;Research;rib bone structure;Salamander;Signal Induction;Spanish;stem cell proliferation;stem cells;Time;Tissue-Specific Gene Expression;Tissues;Vertebrates;Work

PROJECT_TITLE: Molecular and cellular mechanisms underlying the nerve dependence of regeneration


ORG_CITY: BALTIMORE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: Neurodevelopmental disorders have devastating and lasting consequences and are more likely in males and individuals experiencing inflammation early in life. Mast cells are an innate immune cell that reside in the brain and contribute to both normal development and inflammation, but how these roles are manifest is poorly understood and the goal of the proposed studies

PI_NAMEs: MCCARTHY, MARGARET M. (contact)

PROGRAM_OFFICER_NAME: TONELLI, LEONARDO HERALDO

PROJECT_TERMS: Affect;Allergic Reaction;Apraxia;Attention;autism spectrum disorder;Blood - brain barrier anatomy;blood-brain barrier permeabilization;Bone Marrow;Brain;brain cell;Cell Degranulation;Cell division;Cell Proliferation;Cells;Child Health;comparative;cranium;critical period;Cytoplasmic Granules;deep sequencing;density;dentate gyrus;Development;Developmental Delay Disorders;Diagnosis;Disease;Epigenetic Process;epigenetic regulation;Epilepsy;Event;Exhibits;experience;Female;Fluorescein-5-isothiocyanate;Funding;Gender;Gene Expression Profiling;Genetic Transcription;Goals;granule cell;Health;Hematopoietic;Heterogeneity;Hippocampus;Histamine;Hormones;Hyperactivity;Hypersensitivity;Hypothalamic structure;Immune;improved;Individual;Inflammation;Inflammation Mediators;Innate Immune System;Label;Laboratory Rat;Learning Disabilities;Life;male;mast cell;Measures;Mediating;member;Microglia;migration;Modeling;Morphology;Neurodevelopmental Disorder;neuroinflammation;Neurologic;Neurons;neutralizing antibody;novel;Outcome;pathogen;Peripheral;pharmacologic;Population;postnatal;Preoptic Areas;Prevention;Proliferating;Prostaglandins;Proto-Oncogene Protein c-kit;Reporting;Risk;Risk Factors;Role;Schizophrenia;sex;Sex Differences;Sex Differentiation;Short-Term Memory;Source;Speech;Stem Cell Factor;Stimulus;Synapses;Testing;Therapeutic Intervention;Tissues;transcriptome;Yolk Sac

PROJECT_TITLE: Neuroinflammation, Epigenetics and Male Vulnerability


NIH_SPENDING_CATS: Biotechnology;Genetics;Infectious Diseases;Sexually Transmitted Infections

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: PROJECT NARRATIVE Chlamydia trachomatis is the leading cause of sexually transmitted infection and elicits a major burden on reproductive health throughout the world. This project will globally define Chlamydia genes that are critical for mediating this bacterium’s ability to infect cells and establish acute and severe infections in a murine female genital tract infection model. The knowledge to be gained from these efforts will open up numerous new avenues of investigation for the field focused on determining the molecular function of proteins encoded by the essential genes, as well as potential novel therapeutics and prevention strategies.

PI_NAMEs: HEFTY, P SCOTT;HYBISKE, KEVIN  (contact)

PROGRAM_OFFICER_NAME: VINCENT, LEAH REBECCA

PROJECT_TERMS: Achievement;Acute;acute infection;Alleles;Area;Bacteria;Biological;Biological Models;Biology;Cells;Characteristics;Chimera organism;Chlamydia;Chlamydia Infections;Chlamydia muridarum;Chlamydia trachomatis;clinically relevant;cohort;Complex;Defect;design;Development;Essential Genes;experience;experimental study;female reproductive tract;female reproductive tract infection;Foundations;functional genomics;gene product;Generations;Genes;Genetic;Genetic Determinism;genetic manipulation;Genetic study;Genome;genome-wide;Goals;Growth;Growth and Development function;Horizontal Gene Transfer;Human;human pathogen;Hybrids;In Vitro;in vitro Assay;in vivo;Infection;Influentials;innovation;interest;Interferon Type II;Investigation;Knowledge;Lead;Libraries;Maps;Mediating;Medical History;Membrane;Membrane Proteins;microorganism;Modeling;Modernization;Molecular;mouse model;Mus;Mutagenesis;mutant;Natural History;Nature;novel therapeutics;Organism;Outcome;pathogen;Pathogenesis;pathogenic bacteria;Pathology;Pathway interactions;Phase;Phenotype;Play;pressure;Prevention strategy;protein function;Proteins;reproductive;Reproductive Health;reproductive tract;Research Personnel;Role;Series;Sexually Transmitted Diseases;Shapes;System;Technology;Technology Transfer;tool;Tropism;Ubiquitin;Virulence;Virulence Factors;virulence gene;With laterality;Work

PROJECT_TITLE: Functional genomics for Chlamydia


NIH_SPENDING_CATS: Biomedical Imaging;Congenital Structural Anomalies;Neurosciences;Pediatric

ORG_CITY: SAINT LOUIS

PI_NAMEs: STRAHLE, JENNIFER  (contact)

PROJECT_TERMS: Aftercare;Age;aged;Anisotropy;Axon;axon injury;Brain;Brain region;Brain Stem;Cardiac;Cellularity;Cerebellar tonsil;Cerebellum;Cerebrospinal Fluid;cerebrospinal fluid flow;Circulation;Clinical;clinical predictors;Clinical/Radiologic;cohort;Complex;Corpus Callosum;data-driven model;Demyelinations;Development;diagnostic tool;Diffusion;Disabling;Edema;Enrollment;Etiology;Fiber;foramen magnum;Functional disorder;functional outcomes;glymphatic system;Health;Image;Impairment;Incidental Discoveries;indexing;Inflammation;Injury;interest;Investigation;Japanese;Liquid substance;Lymphatic;Magnetic Resonance Imaging;malformation;Measurement;Measures;Mediating;Morbidity - disease rate;Motion;Movement;multimodality;neurobehavioral;Neurologic;Neurologic Symptoms;Neurological outcome;neurosurgery;novel;novel imaging technique;Operative Surgical Procedures;Orthopedics;Outcome;outcome prediction;Pathologic;Pathology;Pathway interactions;patient stratification;Patients;Pediatrics;Population;Postoperative Period;pre-clinical;Process;prospective;Quality of life;Radial;Radiology Specialty;response;Severities;Severity of illness;SF-36;spectrograph;Spinal Cord;Structure;Surgical Decompression;Symptoms;Techniques;Testing;Tonsil;tool;Translating;Translations;treatment response;United States National Institutes of Health;white matter;Work

PROJECT_TITLE: Microstructural Injury to the Brainstem and Spinal Cord Determines Outcomes in CM and SM


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Contraception/Reproduction;Cost Effectiveness Research;Health Services;Microbiome;Patient Safety;Urologic Diseases;Women's Health Research

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE  Pelvic Floor Disorders (PFD) negatively impact millions of women and are major a source of personal and economic burden. Identification of safe and cost-effective treatment strategies for PFD often requires large-scale, multi-centered, randomized trials to quickly and accurately assess outcomes in a diverse population. The investigators in the San Diego Pelvic Floor Consortium, in collaboration with the other sites and data coordinating center, are poised to remain leaders in development of innovative research ideas, maintenance of high levels of recruitment and retention of subjects in clinical trials, and presentation of results in prestigious venues.

PI_NAMEs: LUKACZ, EMILY S. (contact);MENEFEE, SHAWN A

PROGRAM_OFFICER_NAME: TEPEDE, ABISOLA KAFAYAT

PROJECT_TERMS: Academic Medical Centers;Accreditation;Award;Basic Science;Behavior Therapy;Behavioral Research;California;care costs;Certification;Clinic;Clinical;Clinical and Translational Science Awards;Clinical Pathways;Clinical Research;clinical research site;Clinical Trials;Clinical Trials Network;Collaborations;collaborative approach;Communities;community engagement;Community Health;comparative cost effectiveness;comparative effectiveness;comparative effectiveness trial;Complication;cost effective treatment;Country;Creativeness;Data;Data Analyses;Data Coordinating Center;design;Development;Diagnosis;Dyspareunia;Economic Burden;Enrollment;Environment;Epidemiology;epidemiology study;Ethnic Origin;experience;Fellowship;Female;Fostering;functional outcomes;Funding;Genitourinary system;health difference;Health Maintenance Organizations;health related quality of life;Human;Human Resources;Image;imaging science;implementation science;Individual;Information Dissemination;innovation;Institution;Interdisciplinary Study;Journals;Knowledge;Leadership;Maintenance;Measures;Medical center;Medicine;member;microbiome;microbiome research;Mission;Modeling;multidisciplinary;novel;Operative Surgical Procedures;Outcome Assessment;Pain;Patient Recruitments;Patients;Pelvic Floor Disorders;Pelvic floor structure;Pelvis;Perioperative;Pharmacogenomics;Population Heterogeneity;Procedures;Productivity;Protocols documentation;Qualifying;Questionnaires;racial diversity;Randomized;randomized trial;Reconstructive Surgical Procedures;Recording of previous events;recruit;Research;Research Institute;Research Personnel;Research Project Grants;Resources;retention rate;satisfaction;Sequential Multiple Assignment Randomized Trial;Site;skills;Source;Specialist;Stress Urinary Incontinence;success;Surgical incisions;Surveys;Symptoms;Translational Research;treatment strategy;trial design;Underrepresented Populations;United States National Institutes of Health;Universities;Urethra;urinary;Urinary Retention;Urinary tract infection;Urodynamics;Urologist;Visit;Woman;Work

PROJECT_TITLE: Pelvic Floor Disorders Network Clinical Site Application: The San Diego Pelvic Floor Consortium


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Breast Cancer;Cancer;Climate-Related Exposures and Conditions;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Women's Health Research

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PI_NAMEs: MIGLIORETTI, DIANA L (contact)

PROJECT_TERMS: advanced disease;Affect;Agriculture;Air Pollution;anti-cancer research;Area;Bioinformatics;Biological Sciences;Biometry;Breast Cancer Detection;Breast Cancer Prevention;Cancer Burden;Cancer Center Support Grant;Cancer Control;cancer epidemiology;Cancer Etiology;cancer genetics;cancer health disparity;Cancer Model;cancer prevention;cancer risk;Catchment Area;Center Core Grants;Cervical;Clinical Investigator;Collaborations;college;Colon;Communication;Communities;Comprehensive Cancer Center;Databases;Development;Diagnosis;Direct Costs;Disparity;Doctor of Philosophy;Early Diagnosis;Environmental Exposure;Environmental Science;Epidemiologic Methods;Epidemiologist;Etiology;Evidence based practice;Faculty;Family;Funding;gastric cancer prevention;Goals;Grant;Health Disparities Research;health disparity;health disparity populations;Health Policy;Human;Human Papilloma Virus Vaccination;Image;implementation science;improved;Incidence;Infrastructure;innovation;Institution;Intervention;Journals;Knowledge;Latinx;Leadership;Lung;Malignant Breast Neoplasm;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Measures;medical schools;member;metabolomics;Methodology;microbiota;minority patient;Modeling;Morbidity - disease rate;mortality;next generation;Obesity;Outcome;Outcomes Research;Peer Review;Peer Review Grants;Pilot Projects;Population;population based;Population Genetics;Population Sciences;prevent;Primary Prevention;programs;Public Health;Publications;Publishing;Quality of life;Radiation exposure;recruit;Reduce health disparities;Research;Research Personnel;Resource Sharing;Risk;Risk Assessment;risk mitigation;Rural Population;Schools;Science;Scientist;screening;Screening for Prostate Cancer;screening guidelines;senior faculty;Severities;Smoke;Strategic Planning;Survivors;Technology;Therapeutic;tobacco control;tool;Training;Translating;Veterinary Medicine;Veterinary Schools;Wildfire;Work

PROJECT_TITLE: Population Sciences and Health Disparities Program


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Mental Illness;Physical Injury - Accidents and Adverse Effects;Prevention;Psychosis;Schizophrenia;Serious Mental Illness;Social Determinants of Health;Violence Research

ORG_CITY: ORANGEBURG

ORG_NAME: NATHAN S. KLINE INSTITUTE FOR PSYCH RES

PHR: PROJECT NARRATIVE The development of strategies and interventions for preventing or minimizing violent behavior in individuals with psychotic disorders has been limited, in part, by a lack of information about the effects of antipsychotic medications, and in particular clozapine, on violent acts in community settings. In this project, we will determine whether clozapine, when administered in real-world settings, decreases the risk for violent acts in individuals with schizophrenia at high risk for violence when compared to treatment with other antipsychotic medications, and investigate whether previously identified change mechanisms are operative in the effectiveness setting. Examining clozapine in this way will foster a better understanding of the effects of clozapine on violent acts in community settings and allow us to test a scalable intervention and service delivery approaches that can be broadly implemented using typically available resources, and as such has significant public health implications.

PI_NAMEs: LINDENMAYER, JEAN-PIERRE  (contact)

PROGRAM_OFFICER_NAME: RUDORFER, MATTHEW V

PROJECT_TERMS: Address;Aggressive behavior;Alcohol consumption;Alcohols;Antipsychotic Agents;antisocial behavior;Behavior;blind;Clinical;Clinical Research;clinical research site;Clinical Trials;clinically relevant;Clozapine;Collaborations;community partners;community setting;community violence;Data;Delusions;Development;Diagnostic;Disparate;Effectiveness;effectiveness outcome;effectiveness study;efficacy trial;Ensure;Fostering;Future;high risk;Hostility;Human Resources;improved;Impulsivity;Individual;individual patient;interest;Intervention;intervention delivery;Interview;Link;Measures;Multi-Institutional Clinical Trial;Murder;Neurobiology;New York;open label;Outcome;Outcome Measure;Outpatients;Pathway interactions;Patients;Persons;Pharmaceutical Preparations;Populations at Risk;Positron-Emission Tomography;prevent;primary outcome;Property;Protocols documentation;psychopathic personality;Psychoses;psychotic;Psychotic Disorders;Public Health;Randomized;randomized, clinical trials;Research;Research Domain Criteria;Resources;Risk;Risk Reduction;Running;Safety;Sample Size;Schizophrenia;Sedation procedure;Self-Injurious Behavior;service delivery;Site;social stigma;Spectrum Analysis;substance use;Symptoms;Syndrome;Testing;Time;treatment as usual;treatment effect;Violence;violence prevention;Vulnerable Populations;Work

PROJECT_TITLE: 5/7 Clozapine for the Prevention of Violence in Schizophrenia: a Randomized Clinical Trial


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Behavioral and Social Science;Brain Disorders;Cancer;Clinical Research;Genetics;Hematology;Hodgkin's Disease;Lymphatic Research;Lymphoma;Mental Health;Neurosciences;Pediatric;Pediatric Cancer;Prevention;Rare Diseases;Rehabilitation

ORG_CITY: ROCHESTER

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: Project Narrative Despite having no therapy directed to the brain, many childhood cancer survivors experience treatment-related morbidities including cancer-related neurocognitive impairment decades after treatment. Understanding the biological mechanisms driving long-term neurocognitive impairment would identify high-risk groups and inform on potential interventions to prevent or alleviate symptoms. Therefore, we propose to study several potential aging-related biomarkers and their associations with neurocognitive impairment and decline over time in long- term survivors of Hodgkin lymphoma.

PI_NAMEs: WILLIAMS, ANNALYNN  (contact)

PROGRAM_OFFICER_NAME: GREEN, PAIGE A

PROJECT_TERMS: accelerated epigenetic aging;Acceleration;Adolescent and Young Adult;adverse outcome;Aftercare;Age;age acceleration;Aging;aging process;aging related;Attention;Automobile Driving;Behavior Therapy;Biological;Biological Aging;Biological Markers;blood-brain barrier crossing;Brain;Cancer Biology;Cancer Control;Cancer Survivor;Cancer Survivorship;cancer therapy;career development;CD4/CD8 ratio procedure;Cell Aging;Central Nervous System;childhood cancer survivor;Childhood Hodgkin's Lymphoma;Chronic;Chronology;Clinical;Cognitive aging;cognitive reserve;cohort;Communities;comorbidity;Complex;critical period;cytokine;Data;design;Development;Development Plans;effective intervention;Ensure;Environment;Epidemiologist;Epigenetic age;Epigenetic Process;Exercise;experience;Exposure to;frailty;Frequencies;Future;General Population;glial activation;glutathione peroxidase;Grant;Health;high risk population;Hodgkin Lymphoma survivors;immunosenescence;Impaired cognition;Impairment;Inflammaging;Inflammation;Inflammation Mediators;inflammatory marker;Interleukin-6;International;Intervention;Intervention Trial;Length;Long-Term Survivors;Malignant Childhood Neoplasm;Malignant Neoplasms;Malondialdehyde;Mediating;Memory;Mentors;mild cognitive impairment;Modeling;modifiable risk;Modification;Molecular;Molecular Epidemiology;Morbidity - disease rate;mortality;Mortality Decline;Neurobiology;Neurocognitive;Neurocognitive Deficit;neurocognitive test;Neurodegenerative Disorders;neuroinflammation;Neurons;neuropathology;Neuropsychology;nutrition;Oxidative Stress;oxidized low density lipoprotein;Patient Self-Report;Pediatric Neoplasm;Phase;Physiological;Population;Positioning Attribute;Predisposition;premature;Premature aging syndrome;prevent;Quality of life;Recovery;recruit;reduce symptoms;Research;Research Personnel;Resources;Risk;Risk Factors;Saint Jude Children's Research Hospital;Siblings;skills;Smoking;social;Statistical Methods;Survivors;systemic inflammatory response;telomere;Telomere Shortening;therapy development;Time;TNF gene;Training

PROJECT_TITLE: Aging-Related Biomarkers of Neurocognitive Function in Long-term Hodgkin Lymphoma Survivors


NIH_SPENDING_CATS: Biomedical Imaging;Congenital Structural Anomalies;Machine Learning and Artificial Intelligence;Neurosciences;Patient Safety;Pediatric;Precision Medicine

PI_NAMEs: LIMBRICK, DAVID DELMAR (contact)

PROJECT_TERMS: Affect;Aftercare;Area;Biological;Brain;brain overgrowth;Brain Stem;Cerebellar tonsil;Cerebrospinal Fluid;Characteristics;Chiari Malformation Type 1;Classification;Clinical;clinical center;Clinical Management;clinical practice;Clinical/Radiologic;clinically relevant;Code;comorbidity;Complex;Consensus;Data;Data Set;Derivation procedure;Development;Diagnosis;Dimensions;Disease;disease heterogeneity;disease natural history;Disease Progression;endophenotype;Etiology;Expert Opinion;explainable machine learning;Feedback;foramen magnum;Foundations;Genetic;Genetic Risk;genetic signature;genomic signature;Genomics;Headache;Heterogeneity;Image;Imaging Techniques;improved;Individual;insight;Machine Learning;malformation;Measures;Methods;Modeling;Morphology;Neurological outcome;neurosurgery;novel;Operative Surgical Procedures;Outcome;Outcome Measure;outcome prediction;Pathogenesis;Pathology;patient oriented;Patient Outcomes Assessments;patient subsets;Patient-Focused Outcomes;Patients;personalized medicine;Phenotype;Population;Postoperative Complications;Practice Management;Precision therapeutics;predictive modeling;Process;Quality of life;radiological imaging;Radiology Specialty;Recommendation;Reproducibility;Research;Rest;Role;Scheme;skeletal;Spinal Cord;statistical and machine learning;Structure;surgery outcome;Surgical complication;Symptoms;Syringomyelia;Techniques;Testing;Tonsil;treatment response;treatment strategy;Universities;unsupervised learning;Variant;Vertebral column;Washington

PROJECT_TITLE: Redefining Chiari Type I Malformation through Genetically, Radiologically, and Clinically-Derived Endophenotypes that are Predictive of Long-Term Neurological Outcome


NIH_SPENDING_CATS: Cancer

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: Project Narrative: Given the important contributions made by investigator-surgeons in the past and the need to continue to address urgent questions in the future, there is a critical need to train surgeons to become scientists. The proposed program is designed for surgical residents to spend two years dedicated to training in the conduct of basic and translational research. The goal of our program is to provide a comprehensive curriculum for training surgical residents to become Surgeon Scientists in Basic and Translational Cancer Research.

PI_NAMEs: MCAULIFFE, JOHN  (contact)

PROGRAM_OFFICER_NAME: LIM, SUSAN E

PROJECT_TITLE: Training of Surgeon Scientists in Basic and Translational Cancer Research

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Substance Misuse

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative There are a limited number of laboratories working in the field of alcohol and immunology, all of which benefit from the AIRIG meetings, as the meetings provide a forum for maintaining an open dialog between these research groups. The meetings are intended to be inclusive: 1) bringing research groups together to foster communication and collaboration, 2) allowing junior scientists and those who are new to the field to present their work orally, and 3) introducing alcohol trainees to senior alcohol research faculty who may be able to serve as future mentors to the trainees. The organizers feel that meeting in a friendly, non-competitive setting increases the potential for rapid scientific advancement and may help to keep alcohol and immunology trainees in the field by availing them of the opportunity to meet funded senior faculty and their trainees.

PI_NAMEs: CHOUDHRY, MASHKOOR A;KOVACS, ELIZABETH J. (contact)

PROGRAM_OFFICER_NAME: WANG, JOE

PROJECT_TERMS: Abbreviations;Acceleration;alcohol effect;alcohol exposure;alcohol research;Alcoholism;Alcohols;American;Applications Grants;Area;Baltimore;Biology;Biomedical Research;Body System;career;career development;Chicago;Collaborations;Colorado;Communication;cost;Dedications;Disabled Persons;Educational workshop;Evaluation;Faculty;Fostering;Friends;Funding;Future;Goals;Grant;Group Meetings;gut-brain axis;Home;Housing;Illinois;Immune response;Immune system;Immunity;Immunologist;Immunology;Impairment;Infection;Inflammation;Information Dissemination;Institution;Interest Group;International;Island;Laboratories;Leukocytes;Medical;medical schools;meeting reports;meetings;member;Mentors;Midwestern United States;minority scientist;National Institute on Alcohol Abuse and Alcoholism;Ontario;Oral;Participant;peer support;Postdoctoral Fellow;posters;Preparation;Program Development;programs;Publications;Research;research faculty;Research Personnel;response;Running;Schedule;Scientific Advances and Accomplishments;Scientist;senior faculty;Shock;Societies;student participation;Students;Support Groups;Surveys;symposium;Texas;Time;tissue injury;Tissues;Travel;Universities;virtual;Woman;Work;Writing

PROJECT_TITLE: Alcohol and Immunology Research Interest Group (AIRIG) Meetings

STUDY_SECTION: AA

STUDY_SECTION_NAME: Biomedical Research Study Section[AA-1]


ED_INST_TYPE: UNIVERSITY-WIDE

ORG_CITY: HONOLULU

ORG_NAME: UNIVERSITY OF HAWAII AT MANOA

ORG_STATE: HI

PHR: The project described in this application will develop and pilot test an intervention aimed to facilitate clinical trial enrollment in rural areas. This proposed research is relevant to public health as improving access to cancer clinical trials results in better quality of care, reduced cancer burdens, and lower cancer mortality in rural areas.

PI_NAMEs: OKADO, IZUMI  (contact)

PROGRAM_OFFICER_NAME: WILLIS, TAMARA

PROJECT_TITLE: Development of an electronic tool to improve access to cancer clinical trials in rural areas

STUDY_SECTION: HCRT

STUDY_SECTION_NAME: Healthcare Research Training [HCRT]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Tobacco;Tobacco Smoke and Health

ORG_CITY: DAVIS

PI_NAMEs: FEJERMAN, LAURA  (contact)

PROJECT_TERMS: Address;African American population;anti-cancer research;Area;Asian Americans;aspirate;Awareness;Basic Science;Behavior;bilingualism;California;Cancer Burden;Cancer Center;Cancer Center Support Grant;Cancer Control;Cancer Etiology;cancer health disparity;cancer prevention;cancer type;career development;Catchment Area;Center Core Grants;Clinical Research;Clinical Sciences;Clinical Trials;Collaborations;Communication;community advisory board;community engagement;community organizations;Community Outreach;Comprehensive Cancer Center;County;COVID-19 impact;Data;Data Sources;Education;ethnic minority;Ethnic Origin;Ethnic Population;Extramural Activities;Faculty;Funding;Goals;Hepatitis B Transmission;Hepatitis B Virus;Home;HPV vaccine hesitancy;Human Papilloma Virus Vaccination;Incidence;Infrastructure;Institution;Intervention;Investments;Language;Latino Population;Latinx;Lead;Leadership;life span;Logic;Malignant Breast Neoplasm;Malignant neoplasm of cervix uteri;Malignant neoplasm of prostate;Malignant Neoplasms;Minority;Mission;Modeling;mortality;Native-Born;NCI Center for Cancer Research;Outcome;outreach;patient oriented;Perinatal;Persons;Policies;Population;Population Sciences;programs;Race;racial minority;reduce tobacco use;Research;Research Priority;Resource Sharing;Risk Factors;Rural Population;Sales;screening;Screening for cancer;screening guidelines;Secure;Source;Statutes and Laws;Surveys;tobacco control;tobacco flavor;Tobacco use;Training;Translational Research;United States Preventative Services Task Force;Universities;Update;Vulnerable Populations

PROJECT_TITLE: Community Outreach and Engagement


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Genetics;Human Genome;Neurosciences;Rare Diseases

ORG_CITY: JACKSONVILLE

ORG_NAME: MAYO CLINIC  JACKSONVILLE

PHR: NARRATIVE The ability of glioblastoma to invade brain and proliferate uncontrollably makes this tumor uniformly lethal, and this highlights the need to develop new methods to block both of these components of the malignant phenotype. In this application, we propose that non muscle myosin II represents such a target, and we will investigate how to optimize therapeutic approaches that synergize with its inhibition.

PI_NAMEs: CANOLL, PETER ;KENCHAPPA, RAJAPPA ;ROSENFELD, STEVEN S (contact)

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: Address;Angiogenesis Inhibitors;Apoptosis;Automobile Driving;Brain;Categories;Cells;Complex;Development;Disease;Dose;Drug Synergism;effective therapy;Environment;Epidermal Growth Factor Receptor;falls;Family;Family member;Genetic;Genetically Engineered Mouse;Glioblastoma;Goals;Growth;Human;Impairment;In Vitro;in vivo;inhibitor;Invaded;Knock-out;malignant phenotype;Measures;Mechanics;meter;Methods;Molecular Motors;Monitor;mouse model;Mus;Myosin Type II;Newly Diagnosed;non-muscle myosin;Nonmuscle Myosin Type IIA;novel;Paralysed;Pathway interactions;Permeability;permissiveness;Pharmaceutical Preparations;Phenotype;phosphoproteomics;Polyploidy;Population;Proliferating;Protein Isoforms;Radiation;Radiosensitization;Resistance;response;Rest;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Slice;small hairpin RNA;small molecule inhibitor;synergism;Testing;Therapeutic;Thick;Tissues;Toxic effect;transcriptome sequencing;Translating;translational study;tumor;tumor growth;tumor progression;Up-Regulation

PROJECT_TITLE: Targeting Go and Grow in Glioblastoma

STUDY_SECTION: DT

STUDY_SECTION_NAME: Developmental Therapeutics Study Section[DT]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Infectious Diseases;Malaria;Orphan Drug;Pediatric;Prevention;Rare Diseases;Vector-Borne Diseases

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: NARRATIVE Malaria remains a major cause of pediatric deaths and morbidity in Africa. Intermittent preventive treatment in pregnancy (IPTp) and childhood (IPTc) have emerged as strategies to decrease childhood morbidity and mortality. The primary objective of this proposal will be to determine whether effective prevention of malaria with IPTp and IPTc can also enhance protective immunity to malaria in young children.

PI_NAMEs: JAGANNATHAN, PRASANNA  (contact)

PROGRAM_OFFICER_NAME: MCGUGAN, GLEN C

PROJECT_TERMS: 1 year old;2 year old;4 year old;adaptive immune response;Address;Affect;Africa;African;Anti-malarials;Antigens;Area;arm;Automobile Driving;Biological Assay;Birth;Blood;Cells;Cessation of life;Chemoprevention;Child;Childhood;Clinical Trials;cohort;critical developmental period;Data;Development;Directly Observed Therapy;early childhood;Enrollment;Falciparum Malaria;follow-up;Funding;Gene Expression;Guidelines;Health Benefit;Immune;Immune response;Immunity;Immunology;immunopathology;immunoregulation;improved;in utero;Incidence;infancy;Infant;Infant Health;Infection;Inflammatory;Innate Immune Response;innovation;Interleukin-10;Intervention;Investigation;Life;Malaria;malaria infection;Malaria prevention;malaria transmission;Morbidity - disease rate;mortality;Mothers;multidisciplinary;Outcome;Parents;Pharmaceutical Preparations;Policies;Population;Predisposition;Pregnancy;Pregnant Women;prenatal exposure;prevent;Prevention;Preventive treatment;primary outcome;protein expression;Pyrimethamine;Randomized;Randomized, Controlled Trials;Regimen;Research Design;response;Risk;Serology;standard of care;Sulfadoxine;System;Testing;Time;TNF gene;Toll-like receptors;Uganda;Vaccine Antigen;Vaccines;Viral Antigens;Women's study

PROJECT_TITLE: Enhancing immunity to malaria in young children with effective chemoprevention


ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project narrative This project will examine the effects of Medicare Advantage (MA) plan influence on post-acute care use and outcomes. This is important because one-third of all Medicare beneficiaries are enrolled in MA plans, nearly half of all Medicare beneficiaries use post-acute care after hospitalization, and post-acute care is a major contributor to increased health care spending but frequently has adverse outcomes. Results will provide guidance on how to alter MA or Medicare fee-for-service practices in order to inform best practice in post-acute care.

PI_NAMEs: BURKE, ROBERT EDWARD (contact)

PROGRAM_OFFICER_NAME: KARACA, ZEYNAL

PROJECT_TITLE: Use of post-acute care and outcomes among Medicare Advantage and fee-for-service beneficiaries

STUDY_SECTION: HSVR

STUDY_SECTION_NAME: Healthcare Systems and Values Research[HSVR]


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities

PI_NAMEs: LARA, PRIMO N. (contact)

PROJECT_TERMS: Address;Advisory Committees;Agreement;Attention;Award;Basic Science;biomedical imaging;Cancer Center;Cancer Center Support Grant;cancer health disparity;career;Catchment Area;Center Core Grants;clinical center;Clinical Investigator;Clinical Sciences;Clinical Trials;Collaborations;community engagement;Community Outreach;Comprehensive Cancer Center;Coupled;Data;Development;Doctor of Philosophy;Early Therapeutic-Clinical Trials Network;Education;Ensure;Evidence based intervention;Extramural Activities;Faculty;Financial Support;Fostering;Funding;Future;Goals;Grant;high risk;Immunologic Monitoring;Immunooncology;Individual;innovation;Institution;Investments;Leadership;Malignant Neoplasms;member;Mission;Molecular;nanomedicine;NCI Center for Cancer Research;pathogen;Patient Recruitments;Pharmacology;Pilot Projects;Population Sciences;programs;Publications;recruit;Renal Cell Carcinoma;Research;Research Personnel;Research Project Grants;Resource Sharing;Role;Science;Scientist;symposium;Talents;Technical Expertise;Training;Translational Research;Viral;Work

PROJECT_TITLE: Developmental Funds