ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

ORG_CITY: PHILADELPHIA

ORG_DEPT: BIOLOGY

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

PHR: NARRATIVE This proposal seeks to sustain and accelerate the development of HyPhy – a widely-used versatile software platform for comparative genetic sequence analysis in a phylogenetic framework. This effort will improve the software, enhance biological realism, relevance, accessibility, and interpretability of the methods, design novel approaches to address outstanding problems in evolutionary data analysis, and further lower access barriers to evolutionary comparative analyses through integration with the Galaxy ecosystem.

PI_NAMEs: MUSE, SPENCER V.;NEKRUTENKO, ANTON ;POND, SERGEI L KOSAKOVSKY (contact)

PROGRAM_OFFICER_NAME: WANG, PEGGY

PROJECT_TITLE: Hypothesis Testing using Phylogenies for the 21st century

STUDY_SECTION: BDMA

STUDY_SECTION_NAME: Biodata Management and Analysis Study Section[BDMA]


ADMINISTERING_IC: MH

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Microbiome;Neurosciences;Pediatric;Prevention

ORG_CITY: Columbus

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PSYCHIATRY

ORG_FIPS: US

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Narrative: Stress exposure during pregnancy is common and disrupts neurodevelopment, increasing the risk of psychiatric disorders in the next generation. How stress is transmitted from peripheral changes in maternal microbes to the developing brain in utero is an open question, and maternal microbes are a tantalizing target for intervention. This interdisciplinary study will focus on this critical window to determine the ability of a tryptophan metabolizing microbe to prevent early inflammatory abnormalities in the developing brain which result in long term behavioral changes.

PI_NAMEs: GUR, TAMAR  (contact)

PROGRAM_OFFICER_NAME: TONELLI, LEONARDO HERALDO

PROJECT_TERMS: Adult;Adult Children;Adult women;Affect;Amino Acids;Antiinflammatory Effect;Anxiety;Aromatic Amino Acids;Attention;autism spectrum disorder;Automobile Driving;Bacteria;bacterial metabolism;Behavioral;Blood Circulation;blood-brain barrier crossing;Brain;commensal microbes;Data;Development;Diet;Dietary intake;Equilibrium;experimental study;Exposure to;fetal;Fetal Development;Fetus;Gastrointestinal tract structure;gut microbiome;gut microbiota;gut-brain axis;Health;Impairment;improved;in utero;indoleacetic acid;Indoles;Inflammation;Inflammatory;Injections;Interdisciplinary Study;Intervention;Intestines;intrauterine environment;Link;Literature;Mediating;Mental Depression;Mental disorders;Metabolism;Methods;Microbe;microbial;microbiome;Microglia;Modeling;Mothers;mouse model;Mus;neurodevelopment;neuroinflammation;Neurons;neuroregulation;next generation;novel;offspring;Outcome;Peripheral;Physiology;Placenta;Play;Pregnancy;prenatal stress;prevent;Process;Production;replication stress;restraint stress;Risk;Shapes;Signal Transduction;Social Behavior;Stress;stress reduction;success;Testing;transmission process;Tryptophan;Tryptophan Metabolism Pathway

PROJECT_TITLE: Orchestrating tryptophan metabolites to protect neurodevelopment from prenatal stress

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


ADMINISTERING_IC: VA

FUNDING_MECHANISM: OTHERS

IC_NAME: Veterans Affairs

ORG_CITY: ANN ARBOR

ORG_NAME: VETERANS HEALTH ADMINISTRATION

ORG_STATE: MI

PHR: Kara Zivin, PhD, MS, MA serves as a productive Department of Veterans Affairs Health Services Researcher, consistently recognized nationally and internationally as a leader in behavioral health (BH) services research and policy. She demonstrates persistent dedication to improving care for Veterans with BH conditions. Her work aims to enhance clinical and functional outcomes through evaluation of intended and unintended consequences of policies and health system initiatives on overall access to, quality of, and costs of care for those with BH conditions, to mitigate BH provider burnout, and to address gaps and unmet needs for perinatal BH care. The proposed Research Career Scientist Award will support her continued research to promote care for Veterans, as well as an expanded role in service, mentorship, and training early career scientists in the next generation of VHA health services researchers and leaders.

PI_NAMEs: ZIVIN, KARA  (contact)

PROJECT_TERMS: Address;Adverse event;Affect;Area;Award;behavioral health;Budgets;burnout;care costs;career;career life balance;Caring;child bearing;Clinic;Clinical;clinical center;Clinical Management;Collaborations;Communities;Complex;Data;Dedications;design;disability;Doctor of Philosophy;Employee Engagement;Employment;Epidemiologist;Evaluation;experience;Foundations;functional outcomes;Funding;Grant;Health;Health Personnel;Health Policy;Health Priorities;health service use;Health Services;Health Services Administration;Health Services Research;Health system;Healthcare;high risk;improved;Individual;innovation;Institution;International;Knowledge;Lead;Leadership;Learning;Mental Depression;Mental Health;Mental Health Services;Mentors;Mentorship;Methods;Michigan;next generation;Outcome;Overdose;Patient Care;Patients;Peer Review;Perinatal;Personal Satisfaction;Pharmaceutical Preparations;pharmacy benefit;Physicians;Policies;Policy Maker;Policy Making;Postpartum Women;Pregnant Women;Primary Care;Principal Investigator;Productivity;programs;Provider;Psychologist;Publications;Quality of Care;Research;research and development;Research Methodology;Research Personnel;Research Priority;Resources;Role;Scientist;Services;severe mental illness;State Government;Substance Use Disorder;Suicide;Suicide prevention;System;therapy development;Training;Treatment outcome;United States Dept. of Health and Human Services;United States Food and Drug Administration;United States National Institutes of Health;Veterans;Veterans Health Administration;Women's Health;Work

PROJECT_TITLE: HSR&D Research Career Scientist Award

STUDY_SECTION_NAME: HSR-7 Capacity Building[HSR7]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Rare Diseases

ORG_CITY: CHICAGO

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Elaborate strategies are used by bacteria to deliver toxic proteins into host cells to manipulate cell signaling and promote infection. Multifunctional-Autoprocessing Repeats-in-Toxins (MARTX) toxins simultaneously deliver two to five effectors into the same cell and thus have been called “cluster bombs”. This study will investigate how the multiple effectors can work in combination to promote infection by Vibrio cholerae, which causes cholera, and Vibrio vulnificus, which causes severe fatal sepsis and necrotizing fasciitis.

PI_NAMEs: SATCHELL, KARLA J F (contact)

PROGRAM_OFFICER_NAME: ZEITUNI, AMIR E

PROJECT_TERMS: Actins;Adenylate Cyclase;Bacteria;Bacterial Proteins;Binding;Biochemical Reaction;biological adaptation to stress;Biological Models;Caspase;Cell membrane;Cells;cellular targeting;Cessation of life;Cholera;Clinical;Complement;Consumption;crosslink;Cues;Cytosol;Data;Death Rate;Dehydration;Diarrhea;Disease;Disease Progression;Endopeptidases;endoplasmic reticulum stress;enteric infection;Epithelial Cells;Event;G Actin;Global Warming;Horizontal Gene Transfer;Hybrids;Immune response;Immune signaling;Immunologic Stimulation;Incidence;Individual;Infection;Inflammation;Ink;insight;intestinal epithelium;Link;Mediating;Membrane;Mitogen-Activated Protein Kinases;Modeling;Molecular;Mutation;Necrotizing fasciitis;novel;pathogen;Pathogenesis;pathogenic bacteria;Pathogenicity;Pattern;Phytic Acid;Plasma Cells;polypeptide;programs;Protease Domain;Protein Secretion;Proteins;rho GTP-Binding Proteins;Seafood;Sepsis;Signal Induction;Signal Transduction;synergism;System;Testing;Time;Toxic effect;Toxin;Variant;Vibrio;Vibrio cholerae;Vibrio cholerae infection;Vibrio vulnificus;Virulence;Virulence Factors;Virulent;Water;Work;Wound Infection

PROJECT_TITLE: Vibrio MARTX toxin effectors in signaling and pathogenesis

STUDY_SECTION: HIBP

STUDY_SECTION_NAME: Host Interactions with Bacterial Pathogens Study Section[HIBP]


ORG_CITY: PROVIDENCE

ORG_NAME: PROVIDENCE VA  MEDICAL CENTER

ORG_STATE: RI

PHR: Nearly 25% of Veterans are estimated to be food insecure, experiencing limited access to nutritionally adequate foods. Food insecurity is associated with a wide range of poor health outcomes as well as higher healthcare costs and utilization. In 2017 the VA launched a national initiative to screen all Veterans in the VA for food insecurity and help connect them with resources. Little is known about variation in screening implementation across VA sites; how sites respond when a Veteran screens positive for food insecurity; or what VA practices following a positive screen best improve Veteran food security status, experiences of care, and health outcomes. This study will address these knowledge gaps by examining the scope of Veteran food insecurity in the VA, variation and site-level innovations in how the screener is being implemented, and Veteran experiences of screening and follow-up. Findings will help optimize screening and referral processes for connecting food insecure Veterans to relevant VA and community resources.

PI_NAMEs: COHEN, ALICIA  (contact)

PROJECT_TERMS: acceptability and feasibility;Acute;Address;Advisory Committees;Area;career;Caring;Chronic;Clinical;clinical encounter;clinical implementation;clinical practice;cohort;Communities;community engaged intervention;community partnership;Consolidated Framework for Implementation Research;Country;data warehouse;design;Dietitian;effective intervention;Eligibility Determination;Emotional;Evaluation;evidence base;experience;Family health status;Family Practice;feasibility testing;Feedback;follow-up;Food;Food Access;food insecurity;food security;Fostering;Foundations;Future;Goals;Health;Health Care Costs;Health Services Research;high risk;Homelessness;implementation science;improved;informant;innovation;Intervention;Intervention Trial;Interview;Investments;Knowledge;Literature;Manuals;Medical;member;Mental Health;Methodology;Methods;Modeling;multi-site trial;novel;Nutritional;Outcome;Patients;Phase;Physicians;pilot test;pilot trial;poor health outcome;Process;prospective;Protocols documentation;Reporting;Research;Research Methodology;Research Personnel;Research Training;Resources;Sampling;Scientist;screening;Services;Site;skills;social health determinants;Social Workers;stressor;Structure;therapy design;Time;Training;Variant;Veterans;Visit;Work

PROJECT_TITLE: Implementing a Clinical-Community Partnered Intervention to Address Food Insecurity Among High-Risk Veterans

STUDY_SECTION_NAME: Research Career Scientist[MRA0]


ORG_CITY: BEDFORD

ORG_NAME: EDITH NOURSE  ROGERS MEMORIAL VETERANS HOSPITAL

ORG_STATE: MA

PHR: Community Living Centers (CLCs) provide care for over 40,000 vulnerable Veterans every year and serve as a safety net setting for many Veterans who cannot find care in non-VA nursing homes. This award will support Dr. Hartmann's research on measuring and improving the quality of CLC care, helping Veterans who live in CLCs have better outcomes. Dr. Hartmann's work to date with CLCs across the nation shows this is possible. CLCs that use techniques she developed have, for example, improved care and risen in their quality rankings. This award will expand this type of research, helping the VA system better provide high-quality Veteran care.

PI_NAMEs: HARTMANN, CHRISTINE W (contact)

PROJECT_TERMS: Acceleration;Address;Adopted;Adoption;American;Applications Grants;Area;Attention;Award;care outcomes;career;career development;Caring;Cladribine;Clinical;clinical care;clinical center;clinical practice;Collaborations;combat;Communities;community living;Congresses;cost;Dementia;Development;evidence base;Evidence based intervention;Face;faculty mentor;Foundations;Frontline worker;Funding;Geriatrics;Goals;Grant;Grant Review;Health;Health Services;Health Services Research;Health system;high risk;high risk population;Home Nursing Care;Homogeneously Staining Region;Hybrids;implementation framework;implementation intervention;implementation science;implementation strategy;implementation study;improved;improved outcome;improvement on sleep;Interest Group;Intervention;Investigation;Investments;Journals;Lead;Long-Term Care;Massachusetts;Measurement;Measures;medical specialties;Mentors;Mentorship;Methodology;Methods;Mission;Modeling;multiple chronic conditions;neglect;news;Nursing Homes;Outcome;Peer Review Grants;person centered;Policies;Positioning Attribute;Pragmatic clinical trial;professor;Publications;Publishing;Quality of Care;Recording of previous events;recruit;Research;Research Personnel;Research Support;Resources;response;Role;safety net;Scientist;Services;Site;Societies;Specialist;Structure;success;System;Techniques;tool;Training;Translating;Underrepresented Populations;United States National Institutes of Health;Universities;uptake;Veterans;Vulnerable Populations;Work


ORG_CITY: LOS ANGELES

ORG_NAME: VA GREATER LOS ANGELES HEALTHCARE SYSTEM

ORG_STATE: CA

PHR: This career award focuses on partnered research about women Veterans’ health and health care as well as approaches to strengthening the healthcare system by supporting providers and staff. The current and planned research portfolio focuses on understanding women Veterans’ healthcare utilization and needs, and implementing flexible, patient-centered care models. Engaging stakeholders (e.g., leaders, staff, Veterans) in the care transformation process is central to the research. The career award enables continuing service to VA as well as mentoring and training early-stage and established investigators in designing, conducting, and disseminating high impact research that will result in improved quality of care for Veterans.

PI_NAMEs: HAMILTON, ALISON B. (contact)

PROJECT_TERMS: Acceleration;Address;Anxiety;Appointment;Area;Award;barrier to care;Behavioral Medicine;biobehavior;cardiovascular risk factor;career;Caring;clinical center;Collaborations;Communication;Community Health;Community Healthcare;Decision Making;design;Development;disability;Dissemination and Implementation;editorial;Education;Educational workshop;Effectiveness;Employee Engagement;ethnographic method;evidence base;Evidence based practice;experience;Fellowship Program;flexibility;Funding;Gender;Goals;Health;health care service utilization;Health Personnel;Health Policy;Health Priorities;Health Sciences;Health Services Research;Healthcare;Healthcare Systems;Homelessness;Homogeneously Staining Region;implementation research;implementation science;implementation strategy;implementation trial;improved;innovation;Internal Medicine;International;Investigation;Journals;K-Series Research Career Programs;Lead;Leadership;learning network;Medical;medical schools;member;Mental Depression;Mental disorders;Mental Health;Mentors;Mentorship;Methodology;Methods;Modeling;National Institute of Drug Abuse;operation;Paper;Pathway interactions;Patient-Centered Care;Peer Review;phenomenological models;Policies;Policy Maker;Population;Prediabetes syndrome;Preventive care;Primary Care;Process;Productivity;professor;Provider;Psychiatry;Public Health;Publications;Published Comment;Publishing;Qualitative Methods;Quality of Care;rapid technique;Research;Research Personnel;residence;rurality;Science;Scientist;Services;severe mental illness;Special Population;Support System;symposium;Testing;Training;United States National Institutes of Health;Veterans;Vulnerable Populations;Woman;Women's Health;Women's Health Services;Women's study;Work


ORG_CITY: PITTSBURGH

ORG_STATE: PA

PHR: Unhealthy alcohol use is common among Veterans and a significant risk factor for numerous negative health consequences, including chronic disease, injury, mortality, and suicide. It is also linked to increased financial and societal costs (e.g., higher healthcare utilization, criminal justice expenses). Due to these burdens, effective, evidence-based care for Veterans with unhealthy alcohol use was implemented in VA primary care settings. However, significant gaps in this care have been identified, indicating that a substantial proportion of Veterans in need of help are not receiving it. Improving the implementation of alcohol-related care in primary care settings has the potential to increase access to both preventive care (e.g., brief counseling interventions) and treatment (e.g., medications for alcohol use disorder), thereby significantly decreasing the harmful health and societal consequences associated with drinking.

PI_NAMEs: BACHRACH, RACHEL LAUREN (contact)

PROJECT_TERMS: acceptability and feasibility;addiction;Address;Adoption;Adult;adverse outcome;Alcohol consumption;alcohol misuse;alcohol screening;alcohol use disorder;Alcohols;Area;care delivery;career;Caring;Centers of Research Excellence;Cessation of life;Chronic Disease;Clinic;Clinical;Clinical Psychology;Consolidated Framework for Implementation Research;Counseling;Criminal Justice;Data;disability;Doctor of Philosophy;drinking;Effectiveness;effectiveness outcome;effectiveness/implementation trial;Ensure;Evaluation;evidence base;Evidence based treatment;experience;Fellowship;Financial cost;financial incentive;Goals;Guidelines;Health;health care service utilization;Health equity research;Health Services;Health Services Accessibility;high risk;implementation evaluation;implementation intervention;implementation outcomes;implementation process;implementation science;implementation strategy;Improve Access;improved;Incentives;Individual;Injury;innovation;Intervention;intervention refinement;Interview;Investments;Knowledge;Leadership;Link;Measures;Medical;Medical Care Costs;medical specialties;meetings;Mental Health;Mentorship;Methodology;Methods;mortality;Opioid;Outcome;patient screening;Patients;Performance;Persons;Pharmaceutical Preparations;Pharmacotherapy;pilot test;Population;population based;Positioning Attribute;Postdoctoral Fellow;Prevention;Preventive care;Primary Care;primary care clinic;primary care provider;primary care setting;process improvement;Provider;Psychologist;Public Health;Qualitative Evaluations;Qualitative Methods;Quality of Care;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;recruit;Reporting;Research;Research Personnel;Research Project Grants;Risk;Risk Factors;Sampling;Scientist;screening;Services;societal costs;suicidal;suicidal risk;Suicide;Suicide prevention;Techniques;Testing;theories;therapy design;therapy development;Time;tool;Training;United States Preventative Services Task Force;Veterans;Work

PROJECT_TITLE: Implementation Intervention to Improve Care for Unhealthy Alcohol Use


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Orphan Drug;Rare Diseases;Tuberculosis

ORG_CITY: UNIVERSITY PARK

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

PHR: NARRATIVE  Drug-resistant strains of Mycobacterium tuberculosis present a critical challenge to world health, and new antibiotic targets must be identified to limit the toll of tuberculosis. This project will establish whether trans- translation can be targeted in M. tuberculosis and test the efficacy of lead compounds in vivo. New antibiotics are expected to be developed from the results of the proposed experiments.

PI_NAMEs: BAUGHN, ANTHONY D;KEILER, KENNETH C (contact)

PROGRAM_OFFICER_NAME: BOYCE, JIM P

PROJECT_TERMS: Acute;acute infection;Animals;Antibiotics;Antimycobacterial Agents;Antitubercular Agents;Bacillus;Bacteria;Binding;Biochemical;Biology;Cells;Cessation of life;Chemical Structure;Chemicals;Chronic;chronic infection;design;Development;Dose;drug candidate;drug development;Drug Kinetics;Drug resistance;Drug Targeting;Drug usage;Drug-resistant Neisseria Gonorrhoeae;efficacy evaluation;efficacy testing;Escherichia coli;Eukaryota;Experimental Genetics;experimental study;Future;Genetic;genetic approach;Goals;Growth;Impairment;In Vitro;in vivo;Individual;Infection;inhibitor;Knowledge;Lead;lead optimization;Libraries;Macrophage;Metabolic Clearance Rate;Modeling;Molecular;Molecular Probes;Molecular Target;mouse model;Multi-Drug Resistance;Mus;mutant;Mycobacterium tuberculosis;Mycobacterium tuberculosis complex;novel;Oral;Organism;Pathway interactions;Pharmaceutical Chemistry;Pharmaceutical Preparations;Physiological;Physiology;Population;Predisposition;Property;Research;Resistance;resistant strain;Ribosomes;Role;side effect;small molecule inhibitor;Sterilization;Stress;structural biology;Structure;Testing;therapeutic development;Tissues;tool;Translations;Tuberculosis;tuberculosis drugs;tuberculosis treatment;Validation;Work;World Health

PROJECT_TITLE: Targeting trans-translation to kill M. tuberculosis non-replicating persister cells

STUDY_SECTION: DDR

STUDY_SECTION_NAME: Drug Discovery and Mechanisms of Antimicrobial Resistance Study Section[DDR]


ORG_CITY: PORTLAND

ORG_NAME: PORTLAND VA MEDICAL CENTER

ORG_STATE: OR

PHR: As an accomplished research health scientist and nurse, my research focuses on improving chronic disease management, including access to services, quality of care, and economic outcomes related to Veterans’ health and healthcare. Understanding the modifiable factors that improve health outcomes and healthcare continues to be highly relevant to the VA and to Veterans. My research contributions have positively impacted clinical practice, health care processes, and establishment of critical resources. I have contributed substantially to training the next generation of scientists. Most importantly, I have engaged patients and families in my research. A VA HSR&D Senior Research Career Scientist Award would enable me to enhance my research and scholarship, mentoring, service, and engagement contributions in addressing the potential for care coordination to improve Veterans’ health and healthcare across VA and community-based care.

PI_NAMEs: HYNES, DENISE M. (contact)

PROJECT_TERMS: Address;Adverse effects;Anemia;Appointment;Award;Awareness;biocomputing;care coordination;care costs;care outcomes;career;Caring;Case Management;Chronic;Chronic Disease;Chronic Kidney Failure;Clinical;clinical practice;Clinical Practice Guideline;Collaborations;college;community based care;Community Healthcare;Congresses;copayment;cost;Cost Savings;COVID-19;Data;Data Analyses;data resource;Data Science;Depression screen;Dialysis procedure;Discipline of Nursing;Disease Management;Doctor of Philosophy;Dose;economic outcome;Erythropoietin;Evaluation;experience;Faculty;Family;Fellowship;Funding;General Population;Genome;Geography;Goals;Grant;Health;health data;health management;Health Policy;Health Services;Health Services Accessibility;Health system;Healthcare;Healthcare Systems;Hearing;Hemodialysis;high risk;Homogeneously Staining Region;Human;implementation efforts;implementation research;implementation science;implementation study;improved;Information Resources;Information Systems;innovation;Institution;Intervention;Joints;Journals;Kidney;Kidney Diseases;Knowledge;Lead;Leadership;Link;Managed Care;Measurement;Medical Economics;Medicare;Medicare/Medicaid;Medication Management;Medicine;meetings;Mentors;Methods;military veteran;Modeling;next generation;Nurses;Oregon;Outcome;Outcome Measure;patient engagement;Patients;Peer Review;Policies;Positioning Attribute;post-doctoral training;Postdoctoral Fellow;Primary Care;Private Sector;Process;Professional Organizations;professor;programs;Provider;Public Health;Public Health Informatics;Publications;Quality of Care;Quality of life;Renal Carcinoma;Research;Research Activity;Research Personnel;Research Training;Resources;Role;routine practice;Saran;Savings;Scholarship;School Nursing;Science;Scientist;Seminal;Services;skill acquisition;Social Work;socioeconomics;Speed;subcutaneous;symposium;System;Technical Expertise;Training;Training Activity;Training Programs;Translations;Universities;Veterans;Vision;Work;working group


ORG_CITY: HINES

ORG_NAME: EDWARD HINES JR VA HOSPITAL

PHR: Over the past 19 years, I have been conducting research in health services, epidemiology, and implementation science in VA. My primary area of research has been focused on prevention and management of infections in Veterans with spinal cord injury/disorder (SCI/D), who are at high risk for infections. Many of these infections are due to multidrug resistant organisms (MDROs); but little research had been conducted in this patient population, particularly in the VA which is the single largest source of care for persons with SCI/D in the U.S. Highlights of my research impacts include developing and disseminating a toolkit on prevention of methicillin-resistant Staphylococcus aureus (MRSA) colonization/infection for patients with SCI/D and educating clinicians about the modifiable risk factors of MDROs and impacts on morbidity and mortality in this population. This award will support my research in this area, collaborations, mentoring, and service activities.

PI_NAMEs: EVANS, CHARLESNIKA T (contact)

PROJECT_TERMS: Address;Admission activity;Antibiotics;Antimicrobial Resistance;Area;Australia;Award;Biometry;Canada;career;Caring;Catheters;China;Chronic;Collaborations;Communicable Diseases;compare effectiveness;Complex;Country;data warehouse;Discipline of Nursing;Disease;Doctor of Philosophy;Engineering;Epidemiologist;Epidemiology;France;Germany;Goals;Government;Guidelines;Health Services;Healthcare;healthcare-associated infections;high risk;Homogeneously Staining Region;Hospitalization;implementation science;improved;Infection;Infection Control;infection management;infection risk;innovation;Journals;Master of Science;Medical center;Medicine;member;Mentors;methicillin resistant Staphylococcus aureus;Methodology;Methods;Mission;modifiable risk;Monitor;Morbidity - disease rate;mortality;Multi-Drug Resistance;multi-drug resistant pathogen;multidisciplinary;Netherlands;Outcome;Paper;Patient Care;patient population;Patients;Peer Review;Persons;Policies;Population;Prevention;Principal Investigator;programs;Publications;Publishing;Registries;Research;Research Activity;Research Design;Research Personnel;research study;Research Support;Risk Factors;Science;Scientist;Services;Source;Spain;Spinal Cord;Spinal cord injury;Statistical Data Interpretation;student mentoring;Students;Switzerland;Techniques;Technology;tool;Training;treatment and outcome;United Kingdom;United States;Universities;urinary;Veterans;Work


ORG_CITY: WEST HAVEN

ORG_NAME: VA CONNECTICUT HEALTHCARE SYSTEM

ORG_STATE: CT

PHR: Intimate partner violence (IPV) is a major public health concern with significant consequences. Veterans experience and perpetrate IPV at rates higher than their civilians counterparts. Although VHA currently recommends routine screening of IPV experiences among women Veterans, no guidelines or tools exist for IPV perpetration screening, and intervention development for IPV perpetration is in its infancy. In order to reduce rates of IPV and improve Veterans' health outcomes, effective and acceptable screening and treatment must exist. The goals of the proposed research are to validate a previously developed IPV perpetration screening instrument and to complete the necessary steps for developing an acceptable, safe, and feasible individual IPV perpetration intervention and manual for Veterans. Research proposed will provide the necessary groundwork for developing and implementing a comprehensive response to IPV and informing VHA policy.

PI_NAMEs: PORTNOY, GALINA ALEXANDRA (contact)

PROJECT_TERMS: acceptability and feasibility;Address;Area;Assessment tool;Behavior Therapy;brief screening;career;Caring;Child;Clinical;clinical practice;Communities;Comprehensive Health Care;Conflict (Psychology);Connecticut;Consensus;Data;design;Detection;effective intervention;effectiveness/implementation trial;evidence base;experience;Family;Feedback;Focus Groups;Funding;Goals;Guidelines;Health;Health Services;Health Services Needs;Healthcare;Healthcare Systems;Home;Homogeneously Staining Region;Hybrids;implementation science;improved;Individual;infancy;innovation;instrument;Intervention;intervention refinement;intimate partner violence;Knowledge;male;Manuals;Measurement;Medical center;men;Mentorship;Methodology;Modeling;Outcome;Patients;Pilot Projects;Policies;Population;Positioning Attribute;post-traumatic stress;Predictive Value;prevent;Prevention;primary outcome;Procedures;Process;programs;Property;Protocols documentation;Provider;psychological violence;Psychologist;Psychometrics;psychosocial;Public Health;Receiver Operating Characteristics;Recommendation;Reference Standards;relationship violence;Reporting;Research;Research Methodology;Research Personnel;research study;response;Risk;routine screening;Safety;Sampling;satisfaction;screening;Screening procedure;secondary outcome;Services;sexual violence;Specificity;substance use;Testing;therapy development;tool;Training;trial design;Validation;Veterans;Veterans Health Administration;violence perpetration;violence victimization;Woman;Women's Health;Women's Health Services;Work

PROJECT_TITLE: Developing Comprehensive Screening and Treatment for Intimate Partner Violence Perpetration


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Cannabidiol Research;Cannabinoid Research;Drug Abuse (NIDA only);Endocannabinoid System Research;Natural Products;Neurosciences;Pediatric;Prevention;Social Determinants of Health;Substance Misuse;Therapeutic Cannabinoid Research

ORG_CITY: OMAHA

ORG_DEPT: PSYCHOLOGY

ORG_NAME: CREIGHTON UNIVERSITY

ORG_STATE: NE

PHR: Project Narrative While the rodent environmental enrichment model has been shown to be protective against various drugs of abuse, the developmental onset of this enrichment has not been elucidated nor have the effects of enrichment on cannabinoid drugs been investigated. The purpose of this study is to determine if the length of exposure to environmental enrichment during adolescence differentially alters brain density of the cannabinoid receptors (CB1R) or the rewarding effects of vaped delta-8 tetrahydrocannabinol, cannabidiol, and mixtures of these compounds. The results of the current proposal will be important in determining whether enrichment during development protects against the rewarding effects of popular vaped cannabinoids.

PI_NAMEs: STAIRS, DUSTIN JEFFREY (contact)

PROGRAM_OFFICER_NAME: MOORE, HOLLY MARIE

PROJECT_TERMS: abuse liability;Adolescence;Adolescent;Adult;Amygdaloid structure;Animals;Area;Autoradiography;Awareness;Behavioral;behavioral phenotyping;Brain;Cannabidiol;cannabinoid drug;cannabinoid receptor;Cannabinoids;Cannabis;CNR1 gene;conditioned place preference;conditioning;Control Groups;density;Development;Dose;Drug abuse;drug abuse vulnerability;Drug Combinations;drug of abuse;drug reward;Drug usage;early adolescence;Endocannabinoids;endogenous cannabinoid system;Environment;environmental enrichment for laboratory animals;Esthesia;experimental study;Exposure to;Farm;Female;Goals;Harvest;Hemp;Hypothalamic structure;Individual Differences;Investigation;Length;Link;Lung;male;Marijuana;marijuana use;Minor;Modeling;neurobiological mechanism;Personality Traits;Persons;Pharmaceutical Preparations;Plants;postnatal;Poverty;Pre-Clinical Model;Predisposition;Prevention strategy;Procedures;protective effect;Publishing;Rattus;receptor density;receptor expression;Recording of previous events;Research;response;Rewards;Rodent;Rodent Model;social;Stress;Structure;Testing;Tetrahydrocannabinol;Time;treatment strategy;vaping;young adult

PROJECT_TITLE: The Developmental Effects of Environmental Enrichment on the Minor Cannabinoid Drug Reward and Cannabinoid Receptor Levels

STUDY_SECTION: BRLE

STUDY_SECTION_NAME: Biobehavioral Regulation, Learning and Ethology Study Section[BRLE]


NIH_SPENDING_CATS: Biotechnology;Gene Therapy;Genetics;HIV/AIDS;Immunization;Immunotherapy;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: ATLANTA

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Adeno-associated viruses (AAV) can be used as gene therapy vectors to deliver and express broadly neutralizing antibodies (bNAbs). One current setback is the host immune response to the vector and expressed bNAb that limits the protective efficacy of the bNAb. Here we use novel strategies to limit the host immune response against AAV-expressed bNAbs, allowing us to optimize expression and evaluate bNAb protective efficacy from SHIV challenges.

PI_NAMEs: GARDNER, MATTHEW RYAN (contact)

PROGRAM_OFFICER_NAME: ZHOU, YAN

PROJECT_TERMS: Address;adeno-associated viral vector;adenovirus mediated delivery;AIDS prevention;Antibodies;Antibody Formation;Antibody Response;Antibody-Producing Cells;antiretroviral therapy;Area;Binding;Capsid;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;cellular transduction;Clinical;Clinical Trials;Combined Modality Therapy;cost;CTLA4-Ig;Data;Dependovirus;detection limit;Development;Disease;DNA cassette;Dose;Effectiveness;Engineering;Evaluation;Foundations;Future;gene therapy;Gene Transduction Agent;Goals;HIV-1;HIV-1 vaccine;Immune;immune checkpoint;Immune response;Immune system;Immune Targeting;Immunity;improved;Individual;Infection;Infusion procedures;inhibitor;Intramuscular;Investigation;Lead;Macaca;Macaca mulatta;Measurement;Mediating;Monoclonal Antibodies;Mus;Muscle;Muscle Cells;neutralizing antibody;nonhuman primate;novel;novel strategies;Ovalbumin;Participant;Pathway interactions;Patients;Pharmaceutical Preparations;Pilot Projects;Plasma;Populations at Risk;prevent;Prevention;Production;programmed cell death ligand 1;programmed cell death protein 1;promoter;protective efficacy;Recombinants;Rectum;Regulatory T-Lymphocyte;research clinical testing;Serum;simian human immunodeficiency virus;SIV;System;T-Lymphocyte;Therapeutic;transgene expression;Transgenes;transmission process;Update;Vaccines;Variant;vector

PROJECT_TITLE: Optimizing AAV delivery of bNAbs for HIV prevention

STUDY_SECTION: HIVD

STUDY_SECTION_NAME: HIV Immunopathogenesis and Vaccine Development Study Section[HIVD]


ADMINISTERING_IC: AG

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: Nashville

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: PROJECT NARRATIVE Functional magnetic resonance imaging (fMRI) signal variations linked with vigilance states, and the subcortical- cortical networks that underlie these fluctuations in vigilance, are being increasingly recognized as fMRI signals of interest both for neuroscience and in studying disease. The F99 phase of this proposal will look at characterizing the influence of vigilance in young healthy adults with an emphasis on subcortical arousal networks as well as initial application of our methods to older adults with mild cognitive impairment. Completion of the F99 phase will provide technical and professional training, in preparation for the transition to an aging focused K00 phase, where the candidate will extend her training to incorporate structural imaging to characterize the impact of structural degeneration on functional networks with respect to age-related cognitive decline.

PI_NAMEs: GOODALE, SARAH E (contact)

PROGRAM_OFFICER_NAME: SUTTERER, MATTHEW

PROJECT_TERMS: Address;Adult;age related;age related neurodegeneration;Age-associated memory impairment;age-related disease;Aging;aging related;alertness;Alzheimer's Disease;Arousal;basal forebrain;behavioral response;Behavioral trial;Biological Markers;Brain;Brain imaging;career;cholinergic;Clinical;clinical biomarkers;Collaborations;common symptom;Data;Data Analyses;design;Detection;Development;Disease;Drowsiness;Electroencephalography;Environment;Faculty;falls;Fatigue;Foundations;Functional disorder;Functional Magnetic Resonance Imaging;functional magnetic resonance imaging/electroencephalography;Goals;healthy aging;Human;Image;image guided;imaging biomarker;Imaging Device;Impaired cognition;improved;independent component analysis;indexing;Institution;interest;Interruption;Knowledge;Laboratories;large datasets;Link;Magnetic Resonance Imaging;Maps;Measures;Mentorship;Methodology;Methods;mild cognitive impairment;Modeling;Neuroanatomy;Neurodegenerative Disorders;neuroimaging;Neurosciences;older adult;pathological aging;Pathway interactions;patient population;Patients;Pattern;Phase;Physiology;Play;Positioning Attribute;Postdoctoral Fellow;potential biomarker;pre-doctoral;Predisposition;Preparation;Research;Research Personnel;Research Training;Resources;Rest;Role;Scientist;sensory stimulus;Signal Transduction;sleep difficulty;Source;Statistical Methods;structural imaging;Structure;System;Training;Universities;Variant;Vascular Cognitive Impairment;vigilance;white matter;Work;young adult

PROJECT_TITLE: Characterizing vigilance in fMRI data and its relation to age-related cognitive impairment.


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Biotechnology;Brain Disorders;Chronic Liver Disease and Cirrhosis;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Emerging Infectious Diseases;Harm Reduction for Substance Misuse;Hepatitis;Hepatitis - C;Immunization;Infectious Diseases;Liver Disease;Opioid Misuse and Addiction;Opioids;Prevention;Social Determinants of Health;Substance Misuse;Vaccine Related

ORG_CITY: MAYWOOD

ORG_NAME: LOYOLA UNIVERSITY CHICAGO

PHR: PROJECT NARRATIVE We propose to develop comprehensive, empirical, data-driven agent-based models for persons who inject drugs (PWID) using Chicago and San Francisco PWID populations, contrasting geographies for high and low hepatitis C incidence. The models would assist hepatitis C vaccine-trial sponsors in designing and evaluating clinical trials and enable policy makers to identify the most effective vaccine-based combination intervention strategies for elimination of hepatitis C that includes direct-acting antivirals and engagement in harm reduction such as medications for opioid use disorder and syringe service programs.

PI_NAMEs: BOODRAM, BASMATTEE ;DAHARI, HAREL  (contact);OZIK, JONATHAN

PROGRAM_OFFICER_NAME: GAUTAM, RAJEEV

PROJECT_TERMS: Advisory Committees;Affect;Anti-viral Agents;Anti-viral Therapy;Area;attenuation;Behavioral;Caring;Chicago;Chronic;Chronic Hepatitis C;chronic infection;Cities;clinical trial recruitment;Clinical Trials;Clinical Trials Design;combination intervention strategy;Communities;Complex;Computer Models;Country;COVID-19;COVID-19 vaccine;Data;design;Diagnosis;Disease;Disparate;Drug usage;Epidemic;epidemic virus;Epidemiologist;follow-up;Future;Geographic Factor;Geography;global health;Goals;Harm Reduction;Health;Hepatitis C;Hepatitis C Antiviral;Hepatitis C Incidence;Hepatitis C Prevalence;Hepatitis C Therapy;Hepatitis C Transmission;Hepatitis C Vaccine;Hepatitis C virus;high risk population;Illinois;Immunity;Immunologist;in silico;Incidence;Individual;Infection;Injecting drug user;injection drug use;Injections;interdisciplinary collaboration;Intervention;Kinetics;Licensing;Literature;Location;mathematical model;medication for opioid use disorder;metropolitan;Modeling;Modification;Needle-Exchange Programs;Outcome;pathogen;Patients;Persons;Pharmaceutical Preparations;placebo group;Policy Maker;Population;Predisposition;Prevalence;prevent;Public Health;randomized, clinical trials;recruit;Research;Research Personnel;Risk;Risk Behaviors;San Francisco;SARS-CoV-2 transmission;Site;social;Social Network;social norm;Statistical Data Interpretation;structural determinants;success;successful intervention;transmission process;trial design;United States;United States Dept. of Health and Human Services;uptake;vaccination outcome;Vaccine Clinical Trial;Vaccine Design;vaccine development;vaccine efficacy;vaccine trial;Vaccines;Viral;Viral hepatitis;Viral Load result;viral RNA;Work;World Health

PROJECT_TITLE: Computational modeling for HCV vaccine trial design and optimal vaccine-based combination interventions

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-N(90)]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

ORG_DEPT: OTHER BASIC SCIENCES

PHR: Project Narrative: Due to the requirement of millions of cells for conventional proximity ligation-based methods, enhancer- promoter interaction data in sensory hair cells is not available, making it difficult to understand enhancer- mediated transcription regulation. We propose to establish a new method to interrogate enhancer-promoter interactions with a small number of cells utilizing the “cut-and-paste” transposition activity of Tn5 transposase, and then to use such method to profile enhancer-promoter interactions in sensory hair cells in the organ of Corti. The results from the proposed project will provide enriched information for us to understand the regulatory networks governing hair cell-specific gene expression and help us identify potential targets to stimulate hair cell regeneration.

PI_NAMEs: TAO, LITAO  (contact)

PROGRAM_OFFICER_NAME: WATSON, BRACIE

PROJECT_TERMS: 3-Dimensional;Address;Cell Count;Cell Differentiation process;Cell Maturation;Cell Nucleus;cell type;Cells;Chromatin;chromosome conformation capture;Clustered Regularly Interspaced Short Palindromic Repeats;Cochlea;Coin;CRISPR interference;Data;Data Set;deafness;Development;Disease;Distal;Enhancers;Epigenetic Process;EZH2 gene;Gene Expression;gene regulatory network;Genes;genetic manipulation;Genetic Transcription;genome-wide;genome-wide analysis;GFI1 gene;Guide RNA;hair cell regeneration;Hair Cells;hearing loss treatment;Investigation;K562 Cells;Knowledge;Labyrinth;Ligation;Mediating;Methods;Modification;next generation sequencing;novel;Organ;Organ of Corti;Paste substance;permanent hearing loss;Persons;promoter;Protocols documentation;Quality Control;Regenerative Medicine;Research;Resolution;restraint;Sensory Hair;System;Techniques;Technology;Testing;Therapeutic;Tissues;Tn5 transposase;tool;transcription factor;transcription regulatory network;Transcriptional Regulation;transcriptome;transcriptomics;United States;Validation

PROJECT_TITLE: Dissecting the sensory hair cell nucleus: Development of a novel method for investigating chromatin interactions (Tn5-Capture) in small cell numbers

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


ADMINISTERING_IC: HD

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Clinical Research;Contraception/Reproduction;Genetics;Maternal Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Women's Health Research

ORG_CITY: LA JOLLA

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative Proper interaction of placental cells with the maternal immune system is required for induction of tolerance and a successful pregnancy, but this process goes awry in spontaneous preterm birth. We propose to characterize decidual natural killer (dNK) cell heterogeneity and function in both term and preterm birth. We will then apply these findings from primary dNK cells to induced pluripotent stem cells in order to establish a renewable resource for optimal study of these cells and their interactions with placental cells at the maternal-placental interface.

PI_NAMEs: CHEUNG, VIRGINIA CHU (contact)

PROGRAM_OFFICER_NAME: ILEKIS, JOHN V

PROJECT_TERMS: Alloantigen;Animal Model;Apoptosis;Basal Plate;Biological Assay;Biological Models;Blood;Blood flow;Catalogs;Cell Communication;Cell Physiology;Cell Separation;Cells;Chemicals;Coculture Techniques;cytokine;cytotoxicity;Data;Decidua;Decidua Basalis;Decidual Cell;Decidual Cell Reactions;differentiation protocol;Disease;Endometrial;Endometrium;Environment;Equilibrium;fetal;Fetus;Fibroblasts;First Pregnancy Trimester;Flow Cytometry;Galactose Binding Lectin;Gene Expression;gene function;Gestational Age;Growth and Development function;healthy pregnancy;Heterogeneity;Human;human model;Hypoxia;IL8 gene;Immune;Immune Evasion;in vitro Model;Individual;induced pluripotent stem cell;Inflammatory;insight;Invaded;Ionomycin;K562 Cells;Labor Onset;Leukocytes;Location;Maintenance;maternal immune system;Maternal-Fetal Exchange;Measures;Membrane;Methods;Modeling;Natural Killer Cells;Nature;pathogen;patient derived induced pluripotent stem cells;Patients;peripheral blood;Phenotype;Placenta;Placentation;pluripotent stem cell differentiation;Population;Pregnancy;Pregnancy Outcome;Premature Birth;Premature Labor;Process;Protocols documentation;Publishing;Resources;response;segregation;Series;single-cell RNA sequencing;Staging;Stromal Cell-Derived Factor 1;Surface;Time;Tissues;transcriptome;transcriptome sequencing;transcriptomics;trophoblast;Uterus;Vascular Endothelial Growth Factors;Vascular remodeling;Villous;Work

PROJECT_TITLE: Probing and modeling decidual natural killer cells in preterm birth

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F06-B(20)L]


NIH_SPENDING_CATS: Biotechnology;Coronaviruses;Coronaviruses Vaccines;Data Science;Emerging Infectious Diseases;Genetics;Immunization;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Vaccine Related

ORG_CITY: COLLEGE STATION

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: TEXAS ENGINEERING EXPERIMENT STATION

ORG_STATE: TX

PHR: Messenger RNA (mRNA)-based vaccines have emerged as rapid and versatile candidates to quickly respond to virus pandemics such as coronavirus disease 2019 (COVID-19). However, mRNA vaccines face key limitations, one of which is the inherent chemical instability of RNA. This project will facilitate the prediction and experimental validation of mRNA secondary structure and stabilities, which forms the basis for an efficient platform to design stable mRNA vaccine to fight against infectious diseases including COVID-19.

PI_NAMEs: SUN, QING  (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Adopted;Anti-Bacterial Agents;Chemicals;Code;Cold Chains;Communicable Diseases;Computer Vision Systems;cost;COVID-19;COVID-19 vaccine;Data;Data Set;data-driven model;deep learning;deep learning model;Dependence;design;Developing Countries;Engineering;Enzyme-Linked Immunosorbent Assay;experimental study;Face;Feedback;fighting;Fluorescence;Genetic Transcription;Half-Life;Hydrolysis;Immunogenetics;improved;In Vitro;in vivo;Knowledge;Learning;Length;Mammalian Cell;Messenger RNA;Methods;Modeling;Natural Language Processing;Natural Sciences;novel;Nucleic Acids;pandemic disease;pandemic virus;Performance;Physics;Preparation;Process;Production;Property;protein folding;Proteins;Research;research and development;Research Personnel;response;Rest;RNA;RNA Degradation;RNA Instability;RNA Sequences;RNA Stability;RNA vaccine;Role;rural area;self-attention;Structure;supervised learning;synthetic data;System;Techniques;Temperature;Testing;therapeutic RNA;Training;transfer learning;Translations;tumor;unsupervised learning;Untranslated RNA;Update;vaccine development;Vaccine Production;Vaccines;Validation;Variant;Vertebral column;Viral;Viral Physiology;Western Blotting;Work

PROJECT_TITLE: A deep learning and experiment integrated platform for stable mRNA vaccines development

STUDY_SECTION: MSFD

STUDY_SECTION_NAME: Macromolecular Structure and Function D Study Section[MSFD]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Immunotherapy;Infectious Diseases;Prevention;Rare Diseases

ORG_CITY: COLUMBIA

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

ORG_STATE: MO

PHR: PROJECT NARRATIVE  Brucella infections can cause debilitating disease with relapses of an undulating fever and lifelong complications even with antibiotic treatment; however, mechanisms underlying Brucella’s ability to cause chronic infection remain largely unknown. We have found B cells enhance susceptibility to Brucella by skewing CD4+ T cell responses, and in the proposed studies we will investigate the mechanisms by which B cells modulate CD4+ T cell responses to enhance susceptibility to Brucella infection. Collectively, our results will enhance our knowledge of the pathogenesis of chronic brucellosis and should also have implications for future rational design of Brucella vaccines.

PI_NAMEs: SKYBERG, JEROD  (contact)

PROGRAM_OFFICER_NAME: MUKHOPADHYAY, SUMAN

PROJECT_TERMS: Adoptive Transfer;Affect;Animals;Antibiotic Therapy;Antibodies;Antibody Formation;Antigen Presentation;Antigen-Presenting Cells;Antigens;B-Cell Antigen Receptor;B-Lymphocytes;BLR1 gene;Bone Marrow;Brucella;Brucella Vaccine;Brucellosis;CD4 Positive T Lymphocytes;Cell Communication;Cell Physiology;Cellular Immunity;Chimera organism;Chronic;chronic infection;conditional mutant;Data;Development;Disease;effector T cell;Fever;FOXP3 gene;Future;Goals;Homing;Human;humoral immunity deficiency;Immunity;Immunoglobulin Class Switching;Immunoglobulin G;Immunoglobulin M;immunomodulatory strategy;Impairment;improved;in vivo;Infection;Infection Control;Interleukin-10;Knowledge;Licensing;Mediating;Mus;Mutant Strains Mice;neglect;Pathogenesis;Phenotype;Predisposition;preservation;prevent;Production;Public Health;rational design;Receptor Signaling;Regulatory T-Lymphocyte;Relapse;Resistance;Role;Signal Transduction;Sterility;T cell response;T-Cell Activation;T-Cell Development;T-Lymphocyte;Testing;uptake;vaccine efficacy;Vaccines;Zoonoses

PROJECT_TITLE: B Cell/T Cell Interactions in Brucellosis

STUDY_SECTION: IHD

STUDY_SECTION_NAME: Immunity and Host Defense Study Section[IHD]


NIH_SPENDING_CATS: Bioengineering

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: PROJECT NARRATIVE Activation of T cells by dendritic cells is essential for the initiation of adaptive immunity to pathogens. This proposal addresses a poorly understood aspect of this process, the mechanisms through which forces exerted by cytoskeletal elements coordinate signaling events at the cell-cell contact site. The knowledge gained from these studies will be important for optimizing vaccine development, and for modulating immune responses in patients with immunodeficiency and autoimmune disease.

PI_NAMEs: BURKHARDT, JANIS K. (contact)

PROGRAM_OFFICER_NAME: MALLIA, CONRAD M

PROJECT_TERMS: Actins;adaptive immunity;Adaptor Signaling Protein;Address;Adhesions;Agonist;Antigens;Autoimmune Diseases;Award;Binding;Biochemical;Biochemistry;Biological;Biological Assay;biophysical analysis;biophysical properties;Biophysics;Cell Surface Receptors;Cells;Characteristics;Complex;Consensus;Cues;Cytoplasm;Cytoskeleton;Data;Dendritic Cells;Discrimination;DNA;dynamic system;Elements;Environment;Event;experience;Feedback;genetic approach;Glass;Hydrogels;IL2 gene;Immobilization;Immune response;immunodeficiency;immunological synapse;immunoregulation;Integrins;Kinetics;Knowledge;Lead;Ligands;Lipid Bilayers;Mass Spectrum Analysis;Measures;mechanical force;mechanical signal;Mechanics;mechanotransduction;Microscopy;Modeling;Molecular Genetics;Monitor;Output;pathogen;Pathway interactions;Patients;Pattern;Peptide/MHC Complex;pharmacologic;Phosphorylation;Physiological;polymerization;Polymers;Process;Property;prototype;response;Role;Sampling;sensor;Signal Pathway;Signal Transduction;Signaling Molecule;single molecule;Site;Stretching;Surface;System;T cell response;T-Cell Activation;T-Lymphocyte;Testing;Thymus Gland;Transcriptional Regulation;Translations;Tyrosine Phosphorylation;vaccine development;Video Microscopy;Work

PROJECT_TITLE: Mechanobiology of the immune synapse: signal integration via actin dynamics

STUDY_SECTION: CMIA

STUDY_SECTION_NAME: Cellular and Molecular Immunology - A Study Section[CMIA]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences

ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Narrative Neuroplasticity is essential for chemosensory-mediated behavior in social animals. Ants are highly social and provide a new platform to study chemosensory neural development and complex social behavior. We have developed genetic tools in ants to study how neural development and plasticity are modulated for their social communication.

PI_NAMEs: YAN, HUA  (contact)

PROGRAM_OFFICER_NAME: SULLIVAN, SUSAN L

PROJECT_TERMS: Address;Adult;Afferent Neurons;Age;Aggressive behavior;Alzheimer's Disease;Animal Model;Animals;Anosmia;Ants;Apoptosis;autism spectrum disorder;Behavior;Brain;Caspase;Cell Death;Cells;Complex;Defect;Dendrites;Development;Drosophila genome;Drosophila genus;experimental study;Failure;Fluorescent in Situ Hybridization;G-Protein-Coupled Receptors;Gene Expression;Genes;Genetic;Genome;Human;Immune Response Genes;In Situ Nick-End Labeling;injury recovery;Insecta;Lead;Learning;Lobe;Mammals;Mediating;Memory;Modeling;Molecular;mRNA Differential Displays;Mus;mutant;Mutation;Nervous System Disorder;neural circuit;neurodevelopment;neuron development;neuron loss;neuronal circuitry;Neuronal Plasticity;neuronal survival;Neurons;novel;Nurses;Odorant Receptors;Odors;olfactory bulb;Organism;Parkinson Disease;Partner in relationship;Pattern;Quality of life;Reaction;receptor;receptor expression;Receptor Gene;response;Role;Schizophrenia;Sensory;Sensory Receptors;sensory system;Series;Shapes;single-cell RNA sequencing;Smell Perception;social;Social Behavior;social communication;social deficits;Social Environment;Social isolation;Stains;Structure;System;Testing;Time;tool;trafficking;transcriptome;transcriptome sequencing

PROJECT_TITLE: Neuroplasticity in chemosensory-mediated social behaviors

STUDY_SECTION: NIC

STUDY_SECTION_NAME: Neuroscience of Interoception and Chemosensation Study Section[NIC]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Pediatric;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF HOUSTON

PHR: PROJECT NARRATIVE These exploratory studies are relevant to public health for two reasons. First, they provide proof- of-concept evidence for the existence of dialect mismatch effects that hampers learning in Black children. Secondly, they may demonstrate that dialect mismatch is itself related to individual differences in the general language ability of Black children. .

PI_NAMEs: MILLS, MONIQUE T (contact)

PROGRAM_OFFICER_NAME: STORKEL, HOLLY LYNN

PROJECT_TERMS: 7 year old;Academic achievement;African American;Age;American;bilingualism;Black race;Child;Clinical;clinical practice;Collaborations;Comprehension;Data;density;Detection;Development;Diagnostic;Economics;Education;education cost;educational atmosphere;Equation;Evaluation;evidence base;Exposure to;Goals;indexing;Individual;Individual Differences;Inequality;insight;Interruption;Language;Language Development Disorders;language processing;Laws;Lead;Learning;Linguistics;Link;Mainstreaming;Maps;Measures;Mental Health;Methods;Modeling;ophthalmic examination;Outcome;Participant;Pattern;Performance;Personal Satisfaction;phonology;physical conditioning;Positioning Attribute;processing speed;Production;Public Health;Publications;racial disparity;Reading;reading ability;Research;Risk;School-Age Population;Schools;screening;skills;social;Stimulus;Substance abuse problem;substance use;Technology;Testing;Time;Underachievement;Variant;Visual;visual tracking;Washington

PROJECT_TITLE: Dialect Detection in School-age Black Children: An Eye-tracking Study

STUDY_SECTION: LCOM

STUDY_SECTION_NAME: Language and Communication Study Section[LCOM]


NIH_SPENDING_CATS: Neurosciences

ORG_CITY: BALTIMORE

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative This program will provide research and professional development training in otolaryngology to residents and medical students. The research education planned as part of this award is critical for their development as clinician-scientists who will ultimately contribute to the understanding and treatment of conditions that affect communication and the senses of hearing, balance, taste, and smell.

PI_NAMEs: CAREY, JOHN PATRICK (contact);LAUER, AMANDA M.

PROGRAM_OFFICER_NAME: RIVERA-RENTAS, ALBERTO L

PROJECT_TERMS: Academic achievement;Affect;Area;Auditory;Award;Biomedical Research;career;clinical practice;Communication;Communication impairment;Creativeness;Dedications;Development;Dizziness;Ecosystem;education planning;education research;Educational Curriculum;Enrollment;Environment;Equilibrium;experience;Exposure to;Faculty;Feedback;Foundations;Funding;Future;Goals;graduate medical education;graduate student;Head and Neck Cancer;Head and Neck Surgery;Health Professional;Hearing;improved;Individual;innovation;Institution;interest;Knowledge;Laboratories;Leadership;medical schools;medical specialties;Medical Students;member;Mentors;Mission;Molecular Biology;Molecular Epidemiology;National Institute on Deafness and Other Communication Disorders;Nervous System;Operative Surgical Procedures;Otolaryngology;Outcome;Papillomatoses;Participant;Pathogenesis;peer;Physicians;programs;Public Health;Recording of previous events;recruit;Reproducibility;Research;research facility;Research Personnel;Research Training;Residencies;Resources;respiratory;Robotics;Safety;Scientist;Sinusitis;skills;Smell Perception;Solid;Stenosis;Student recruitment;Students;Taste Perception;Therapeutic;tool;Training;Underrepresented Populations;Universities

PROJECT_TITLE: Research Training in Otolaryngology Program

STUDY_SECTION_NAME: Special Emphasis Panel[ZDC1 SRB-X (27)]


ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative Cryptococcus neoformans is an opportunistic fungal pathogen that is the causative agent of cryptococcal meningitis, a severe HIV-associated infection of the central nervous system. In healthy individuals, C. neoformans establishes latent infections that reactivate and cause clinical symptoms upon immunosuppression. Insights gained from this study will improve our understanding of the host immune conditions required to control latent C. neoformans infection, and may lead to new therapeutic targets that prevent reactivation of latent infection and mitigate disease progression in HIV/AIDS patients with cryptococcal meningitis.

PI_NAMEs: DING, MINNA  (contact)

PROGRAM_OFFICER_NAME: LOVE, DONA

PROJECT_TERMS: Acute;adaptive immune response;Address;AIDS-Related Opportunistic Infections;Autopsy;Biopsy;Caring;CD4 Positive T Lymphocytes;Cell Count;Cells;Cellular Immunology;Central Nervous System Infections;Clinical;Communicable Diseases;Containment;Cryptococcal Meningitis;Cryptococcosis;Cryptococcus neoformans;Cryptococcus neoformans infection;Data;Defect;Desiccation;design;Development;Disease;disease model;Disease Progression;Doctor of Philosophy;early childhood;experimental study;Exposure to;Fostering;Goals;Granuloma;Granulomatous;Growth;Histologic;HIV;HIV/AIDS;Human;Immune;immune function;immune reconstitution;Immune response;Immune system;Immunocompetent;Immunocompromised Host;Immunology;immunomodulatory strategy;Immunosuppression;improved;Individual;Infection;Inflammatory;Inhalation;insight;Interferon Type II;Kinetics;laser capture microdissection;latent infection;Life;Link;logarithm;Lung;Lung infections;Macrophage Activation;Mediating;Meningitis;Modeling;mortality;mouse model;Mus;new therapeutic target;novel;opportunistic pathogen;pathogenic fungus;Patients;Phenotype;Physicians;Population;prevent;Production;programs;Proliferating;pulmonary granuloma;Rattus;reactivation from latency;Regimen;Reproduction spores;Research;Research Personnel;response;Risk;RNA analysis;Scientist;Signal Transduction;Structure;Structure of parenchyma of lung;Supplementation;Symptoms;Syndrome;T cell response;T cell therapy;T-Cell Depletion;T-Lymphocyte Subsets;targeted treatment;Techniques;Testing;Th1 Cells;Therapeutic;therapy development;Time;Tissue-Specific Gene Expression;Training;transcription factor;transcriptome sequencing;Translational Research;Yeasts

PROJECT_TITLE: The adaptive host response to latent cryptococcosis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F17-M(20)L]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biotechnology;Clinical Research;Genetics;Immunization;Immunotherapy;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_CITY: NEW ORLEANS

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: NARRATIVE Pneumocystis remains a significant cause of pneumonia with a high death rate in the US among HIV+ patients well as in other immunocompromised hosts. The estimated annual costs of PJP approximate $1B annually in the US. This grant will identify novel targets to improve treatment outcomes as well as improve diagnostics for this pneumonia in patients lacking CD4+ T-cell immunity such as advanced AIDS.

PI_NAMEs: KOLLS, JAY K (contact)

PROGRAM_OFFICER_NAME: LIU, BAOYING

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Africa;anti-microbial drug;Antibodies;Antibody Response;Antigens;Antimicrobial Resistance;Asia;Aspergillosis;Biological Assay;Bronchoscopy;Candida;CD4 Lymphocyte Count;CD4 Positive T Lymphocytes;Child;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;Complement;Complication;cost;Cyst;Data;Death Rate;Detection;Diagnosis;Diagnostic;diagnostic assay;Drug Interactions;efficacy evaluation;experimental study;Far East;Funding;Fungal Proteins;fungus;Genes;Genetic Heterogeneity;Glucans;Grant;HIV;HIV Infections;HIV Seronegativity;Hospitalization;Host Defense Mechanism;Human;Humoral Immunities;immune reconstitution;Immune Sera;Immunity;Immunization;Immunize;Immunocompromised Host;immunogenicity;Immunological Models;Immunotherapy;improved;In Vitro;Infection;Label;Legal patent;Life;Ligase;Liquid substance;Lung;Metabolic;Modeling;Monoclonal Antibodies;mortality;mouse model;Mucous Membrane;Mus;North America;novel;Organism;Patients;Phagocytosis;Pharyngeal structure;Pneumocystis;Pneumocystis carinii Pneumonia;Pneumocystis Infections;Pneumonia;polyclonal antibody;prevent;Prevention;Proteins;Proteome;Pulmonary Inflammation;Resolution;Risk;Sampling;Specific qualifier value;Specimen;Stains;subcutaneous;Surface;Swab;Syndrome;Techniques;Technology;Testing;Therapeutic;therapeutic evaluation;transcriptome;transcriptome sequencing;transmission process;Treatment Efficacy;Treatment outcome;Trimethoprim-Sulfamethoxazole;Urine;Vaccines;Visualization;Western Asia;Yeasts

PROJECT_TITLE: Improved Therapeutics and Diagnostics for Pneumocystis Pneumonia

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;HIV/AIDS;Infectious Diseases;Prevention

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE The lack of an objective PrEP adherence monitoring tool has led to inefficient counseling and poor supportive care. We recently developed a novel enzymatic assay that semi-quantitatively measures the concentration of TFV-DP by measuring inhibition of reverse transcriptase, which is the cellular target of oral PrEP drugs. In this proposal, we will optimize the REverSe TRanscrIptase Chain Termination (RESTRICT) assay to measure TFV- DP concentrations in PrEP clients, validate the assay to meet CLIA requirements, and conduct a feasibility and acceptability study among PrEP clients and providers.

PI_NAMEs: DRAIN, PAUL K (contact);POSNER, JONATHAN D

PROGRAM_OFFICER_NAME: SHARMA, USHA K

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;Adult;Algorithmic Analysis;Biological Assay;Blood specimen;Calibration;cellular targeting;Client;Clinic;Clinical;clinical efficacy;clinically relevant;Counseling;Data;Data Analyses;Data Collection;Diabetes Mellitus;Diphosphates;Drug Kinetics;emtricitabine;experience;follow-up;Fumarates;Glycosylated hemoglobin A;Goals;Guidelines;Half-Life;HIV;Human;implementation science;implementation study;improved;in-vitro diagnostics;Ingestion;Interview;Laboratories;Liquid Chromatography;Measurement;Measures;Medical center;medication compliance;meetings;Monitor;novel;novel strategies;Oral;Outpatients;Patient Self-Report;Patients;Pharmaceutical Preparations;pill;Population;pre-exposure prophylaxis;Predisposition;Preparation;prevent;Procedures;prospective;Provider;Qualifying;Randomized;Reporting;Research;Resources;RNA-Directed DNA Polymerase;Sampling;Structure;Supportive care;Surveys;tandem mass spectrometry;Tenofovir;Testing;tool;Training;transmission process;Universities;Urine;Validation;validation studies;Visit;Washington;Whole Blood

PROJECT_TITLE: A novel REverSe Transcriptase Chain Termination (RESTRICT) assay for near-patient, objective monitoring of long-term PrEP adherence

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Clinical Research;Physical Injury - Accidents and Adverse Effects

ORG_CITY: NEW HAVEN

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: YALE UNIVERSITY

PHR: Public Health Relevance Statement The burden of disease caused by trauma and injury in Lebanon and the Eastern Mediterranean Region is disproportionately high compared to other regions around the world. Yale University and the American University of Beirut seek to build upon their existing successful training and research collaborations to develop a new program to address the severe public health impact of trauma and injury by strengthening capacity at multiple levels of the trauma and injury research ecosystem. We propose a comprehensive program of theoretical and applied skill development; evidence-based policy development; and research and career development mentorship to enable a new cadre of researchers to launch successful career as independent trauma and injury investigators.

PI_NAMEs: AL-HAJJ, SAMAR ;MOWAFI, HANI  (contact)

PROGRAM_OFFICER_NAME: LEVINTOVA, MARYA

PROJECT_TERMS: American;career;Cessation of life;Country;Coupled;Critical Thinking;Data;Death Rate;disability;Disparity;Doctor of Philosophy;Ecosystem;Educational workshop;Ensure;evidence base;experience;faculty mentor;Future;Government;Health;HIV;Human Resources;Income;Infrastructure;Injury;injury burden;injury surveillance;injury-related death;Institution;Knowledge;Lebanon;low and middle-income countries;Malaria;Mediterranean Region;meetings;Mentorship;mortality;Motor;novel;novel strategies;Policies;Population;prevent;Program Sustainability;programs;recruit;Research;Research Personnel;Risk Factors;Safety;Science;Scientist;skills;Structure;Training;Trauma;Universities;Urbanization;Youth

PROJECT_TITLE: Yale-American University in Beirut Program on Advanced Injury Research (Yale-AUB PAIR Consortium)


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Hearing Loss;Neurosciences;Sleep Research

ORG_CITY: JACKSON

ORG_NAME: UNIVERSITY OF MISSISSIPPI MED CTR

ORG_STATE: MS

PHR: We have discovered that: 1) Orexin peptides and receptors, typically considered to be involved with sleep-wake cycles and feeding behaviors, are also expressed in the cochlea, and 2) that ablation of the gene responsible for producing the Orexin peptides exacerbates noise-induced hearing loss. Approximately 30% of US adults report symptoms of insomnia, and while medications used to alleviate insomnia are meant to be used for a short time, many people continue taking insomnia medication for long periods. Because a relatively new insomnia medication silences the Orexin receptors, individuals using this drug long-term could be at previously unrecognized risk for cochlear dysfunction and general hearing loss.

PI_NAMEs: VETTER, DOUGLAS E (contact);YEE, KATHLEEN TRACY

PROGRAM_OFFICER_NAME: CYR, JANET

PROJECT_TERMS: Ablation;Adenylate Cyclase;Adult;age related;aging population;AMPA Receptors;antagonist;Anxiety;Attenuated;auditory stimulus;Behavior;Brain;Cells;chemokine;cholinergic;Cochlea;Code;Cyclic AMP-Dependent Protein Kinases;cytokine;Data;dorsal horn;drug clearance;Drug usage;experience;Exposure to;Family;Feeding behaviors;Fiber;Functional disorder;Genes;Genetic;genetic manipulation;Glutamate Receptor;Glutamates;Goals;Growth;Hair Cells;Health;Hearing;hearing impairment;hypocretin;Hypothalamic structure;Immune;immune cell infiltrate;Immune response;Immunohistochemistry;immunoregulation;Individual;Infarction;Inflammation;Inflammatory;Inflammatory Response;Investigation;Ion Channel;Knockout Mice;Knowledge;Ligands;Link;Macrophage;Maintenance;Marketing;Mediating;Metabolic;Mind;Morphology;Mus;Narcolepsy;Nerve Fibers;neural;Neurons;Neuropeptides;neurotransmission;neurotransmitter release;Noise;noise exposure;Noise-Induced Hearing Loss;novel;null mutation;Older Population;orexin A;orexin B;Pain;Pathway interactions;Patients;Peptides;Peripheral;permanent hearing loss;Persons;Pharmaceutical Preparations;Pharmacologic Substance;Physiological;Play;Population;Post-Traumatic Stress Disorders;postsynaptic;Predisposition;preprohormone;Process;protein expression;Proto-Oncogene Proteins c-akt;Pruritus;receptor;receptor expression;Recovery;Regulation;Reporting;Research;response;Risk;Role;Safety;Shapes;Signal Pathway;Signal Transduction;Sleep;sleep abnormalities;sleep pattern;Sleep Wake Cycle;Sleeplessness;sound;Spinal Cord;Stains;Stroke;Supporting Cell;Symptoms;Synapses;System;Techniques;theories;Time;Tissues;trafficking;Wild Type Mouse;Work

PROJECT_TITLE: Orexin Signaling in the Mouse Cochlea


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences;Women's Health Research

ORG_CITY: KANSAS CITY

ORG_NAME: STOWERS INSTITUTE FOR MEDICAL RESEARCH

PHR: 8. Public Health Relevance.  Social communications are critically dependent on the proper processing of social information. The social cues detected by the sensory systems can induce neuroendocrine responses that control multiple aspects of the nervous system and elicit innate behaviors. The proper function of these systems is crucial to the health and wellbeing of human beings. Malfunction of these sensory systems that result in the improper processing of sensory information can lead to deficit in cognitive function and psychiatric disorders. By investigating the neural circuitry that mediates social communications among animals, which has a direct influence on the endocrine control of reproductive and aggressive behaviors, we will be able to elucidate the functional logic of the circuit and provide insights into the brain mechanisms of processing sensory information, mediating social communications, and exerting endocrine control. This knowledge can be used for diagnostic and therapeutic applications.

PI_NAMEs: YU, CONGRONG RON (contact)

PROJECT_TERMS: Accessory Olfactory Bulbs;Afferent Neurons;Aggressive behavior;Amygdaloid structure;Animals;Axon;Behavior;Behavioral Assay;behavioral response;Biological Models;Brain;brain cell;Brain region;Cells;cognitive function;Complex;Cues;Detection;Diagnostic;Endocrine;Endocrine system;Estrus;Evolution;experience;experimental study;Family;Female;Functional disorder;Genetic;Goals;Health;Human;Hypothalamic structure;Immediate-Early Genes;Individual;information processing;innovation;insight;Instinct;Knowledge;Label;Link;Logic;male;Maps;mating behavior;Mediating;Mental Depression;Mental disorders;mitral cell;Modality;Molecular;molecular imaging;Mood Disorders;Mus;Nature;Nervous System;neural circuit;Neural Pathways;neuromechanism;Neurons;Neurosecretory Systems;Olfactory Pathways;optogenetics;Output;Partner in relationship;Pathway interactions;Pattern;Personal Satisfaction;Pheromone;Play;Population;Population Process;Primates;Process;public health relevance;Publishing;receptor;Reproductive Behavior;Resolution;response;Ritual compulsion;Rodent;Role;Sensory;sensory input;sensory mechanism;sensory system;sex;Sex Attractants;Sex Behavior;Sexual Dysfunction;sexual identity;Sexual Maturation;Signal Transduction;single-cell RNA sequencing;social;Social Behavior;social communication;Social Controls;System;Territoriality;Testing;Therapeutic;tool;transmission process;Vertebrates;Viral;vomeronasal organ;Vomeronasal Systems

PROJECT_TITLE: Circuit Mechanism of Pheromone Processing and Innate Behavior


NIH_SPENDING_CATS: Aging;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Project Narrative Basement membranes are conserved, complex, and specialized extracellular matrices that underlie and surround tissues to support their structure and function. Aging tissues display changes in basement membrane structure, including thickening and collagen accumulation, that may promote the decline of tissue function over time (vision, hearing, stem cell renewal). The proposed work will develop a new animal model to rigorously determine the mechanisms and consequences of these changes, thus providing new insights into the pathology of aging tissue decline.

PI_NAMEs: RAMOS-LEWIS, WILLIAM DAVID (contact)

PROGRAM_OFFICER_NAME: OROSZ, ANDRAS

PROJECT_TERMS: Adult;Affect;Age;age related;age related changes;age related deterioration;Aging;aging process;Agrin;Animal Model;animal tissue;Animals;Atlases;Atomic Force Microscopy;Automobile Driving;Basement membrane;Blood flow;Caenorhabditis elegans;Cells;Collagen;collagen scaffold;Collagen Type IV;Complex;crosslink;Defect;Deposition;Deterioration;Distal;Dystroglycan;Embryo;Epidermis;Excision;experimental study;extend lifespan;extracellular;Extracellular Matrix;feeding;Fertility;Fluorescence Microscopy;Fluorescence Recovery After Photobleaching;fluorophore;Foundations;functional decline;Genes;genome editing;germline stem cells;Goals;Gonadal structure;Growth Factor;Health;Hearing;human disease;Image;in vivo;Individual;insight;Integrins;knock-down;Laminin;life span;Link;Maintenance;Measurement;Measures;Mechanics;Mediating;Membrane;membrane assembly;Membrane Proteins;Modeling;Muscle;Muscle function;mutant;Nerve;Nidogen;oocyte quality;Organ;overexpression;Ovulation;Pathology;Pathway interactions;Peptide Hydrolases;perlecan;Pharyngeal structure;pharynx muscle;Phenotype;Photobleaching;Physiological;prevent;progenitor;Proteins;Pump;Quantitative Microscopy;Recovery;Regulation;Research;RNA Interference;Role;screening;senescence;Signal Transduction;stem cell division;stem cell niche;stem cells;Structure;System;Tensile Strength;Testing;Thick;Thinness;Time;tissue degeneration;Tissues;tool;Transmission Electron Microscopy;Vertebrates;Vision;Visualization;Work

PROJECT_TITLE: Understanding the Mechanisms and Consequences of Basement Membrane Aging in Vivo

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-Q(20)L]


NIH_SPENDING_CATS: Clinical Research;HIV/AIDS;Human Fetal Tissue;Immunotherapy;Infectious Diseases

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE The latent viral HIV reservoir remains a hurdle for the cure of chronic HIV infection, and finding a way to safely and effectively expose this reservoir has been elusive. Here we propose in vitro and in vivo studies exploring an antigen directed dendritic cell-based immunotherapeutic strategy designed to facilitate re-activation and immune elimination of the latent HIV reservoir.

PI_NAMEs: BILITY, MOSES TURKLE;MAILLIARD, ROBBIE B (contact)

PROGRAM_OFFICER_NAME: POON, BETTY

PROJECT_TERMS: Affect;anti-PD-1;Antigens;antiretroviral therapy;Autologous;Binding;Brazil;CD4 Positive T Lymphocytes;Cells;Cellular immunotherapy;checkpoint inhibition;Chronic;Clinical Trials;Combined Modality Therapy;Cytomegalovirus;Cytotoxic T-Lymphocytes;Dendritic Cell Therapy;Dendritic Cells;design;Effector Cell;Epitopes;Evaluation;Event;Exposure to;Gene Modified;HIV;HIV Infections;HIV therapy;humanized mouse;Immune;immune clearance;Immunity;immunogenic;Immunotherapeutic agent;Immunotherapy;In Vitro;in vivo;Individual;Interruption;latent HIV reservoir;Link;Lymphocyte;Malignant Neoplasms;Masks;Mediating;memory CD4 T lymphocyte;MHC Class I Genes;MHC Class II Genes;monocyte;mouse model;novel;Participant;PD-1 inhibitors;PD-1/PD-L1;Peptides;Phase I Clinical Trials;Production;programmed cell death ligand 1;purge;Regulation;Research;Research Personnel;Residual state;response;Role;Sampling;Signal Transduction;Site;T-Lymphocyte;T-Lymphocyte Subsets;Testing;The Multicenter AIDS Cohort Study;Therapeutic;therapeutic evaluation;therapeutic target;TNFRSF5 gene;TNFSF5 gene;Translating;Universities;Viral;Viral Antigens;Viral reservoir;Viremia;Virus Latency

PROJECT_TITLE: Antigen-specific ‘kick and kill’ of the latent HIV reservoir using dendritic cells


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Infectious Diseases;Tickborne Diseases;Vector-Borne Diseases

ORG_CITY: GALVESTON

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

PHR: Narrative E. chaffeensis is an obligately intracellular bacterium that replicates in mononuclear phagocytes by secreting moonlighting effectors that exploit evolutionarily conserved host cell signaling pathways for infection. This investigation will define a pathogen molecular mimicry strategy that promotes host cell survival and E. chaffeensis infection by hijacking the Notch signaling pathway. Defining the role of pathogen mimicry in host cell manipulation and the pathways involved will also provide potential new therapeutic targets for intracellular bacteria.

PI_NAMEs: MCBRIDE, JERE W (contact)

PROGRAM_OFFICER_NAME: PERDUE, SAMUEL S

PROJECT_TERMS: Apoptosis;Apoptosis Inhibitor;Apoptotic;Bacteria;BCL-2 Protein;Binding;BIR Domain;CASP3 gene;Caspase;Cell Communication;Cell Physiology;Cell Reprogramming;Cell Survival;Cells;Development;Disease;Down-Regulation;Ehrlichia;Ehrlichia chaffeensis;Ehrlichiosis;Etiology;Eukaryotic Cell;Event;FBXW7 gene;Genetic Transcription;Genome;Goals;Host Defense;Host Defense Mechanism;Human;Immune;Immune Evasion;in vivo;Infection;Inflammation;Inhibition of Apoptosis;Investigation;Knowledge;Laboratories;Life;Ligands;Link;MCL1 gene;Mediating;Membrane Proteins;mimetics;mimicry;Mitochondria;Molecular;Molecular Mimicry;Mononuclear;new therapeutic target;notch protein;Notch Signaling Pathway;novel therapeutic intervention;Oncoproteins;pathogen;Pathway interactions;Phagocytes;Play;Positioning Attribute;Post-Translational Protein Processing;prevent;programs;Protein Inhibition;protein protein interaction;Proteins;receptor;receptor binding;receptor expression;Receptor Signaling;Regulation;Research;Role;Science;Signal Pathway;Signal Transduction;Surface;System;Tandem Repeat Sequences;tick-borne;TLR2 gene;Toll-like receptors;ubiquitin ligase

PROJECT_TITLE: Ehrlichia Notch SLiM-activated oncoprotein inhibition of apoptosis

STUDY_SECTION_NAME: Host Interactions with Bacterial Pathogens Study Section[HIBP]


PHR: PROJECT NARRATIVE The normal function of the immune system depends on the ability of white blood cells, or lymphocytes, to detect foreign pathogens and respond appropriately so that a pathogen is eliminated without damage to the host. This proposal is designed to expand understanding of the molecular machinery that is used by lymphocytes in this process, and uncover how the mutation or dysregulation of this machinery leads to inappropriate immune cell behavior or the growth of cancers of immune cells, including lymphomas. Our studies may reveal molecular targets for the development of new therapies designed to treat diseases that result from aberrant immune cell behavior including cancer.

PI_NAMEs: POMERANTZ, JOEL L (contact)

PROGRAM_OFFICER_NAME: CASTLEMAN, MORIAH JOVITA

PROJECT_TERMS: activated B cell like;adaptive immune response;Alleles;Antigen Receptors;Antigens;B Cell Proliferation;B-Cell Antigen Receptor;B-Cell Lymphomas;B-Lymphocytes;Behavior;Bromodomain;Bypass;cell behavior;Cell Count;Cells;cofactor;Complex;CRISPR screen;Critical Pathways;design;Development;Disease;Elements;Etiology;gain of function;Genes;Genetic;genome-wide;Growth;Human;Immune;Immune response;immune system function;improved;in vivo;Infection;inhibitor;insight;Kinetics;Knock-in Mouse;Knockout Mice;Knowledge;large cell Diffuse non-Hodgkin's lymphoma;Lesion;Leukocytes;Lymphocyte;Lymphocyte Activation;Lymphocyte Function;lymphocyte proliferation;Lymphoma;Lymphomagenesis;Malignant Neoplasms;Mediating;Molecular;Molecular Target;Mus;Mutation;novel;novel therapeutics;Oncogenic;Output;pathogen;Pathogenicity;Pathway interactions;Patients;Physiological;Predisposition;prevent;Process;Productivity;Proliferating;protein function;Proteins;receptor;Receptor Signaling;recruit;Role;Sampling;scaffold;Scaffolding Protein;Severity of illness;Signal Induction;Signal Pathway;Signal Transduction;Signaling Molecule;Signaling Protein;T-Cell Receptor;T-Lymphocyte;Testing;therapy design;transmission process;Work

PROJECT_TITLE: Mechanisms of Control of Lymphocyte Activation and Proliferation by a Critical Signaling Integrator


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Digestive Diseases;Food Allergies;Immunization;Prevention

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: Peanut allergy is increasing in prevalence and poses a significant public health risk, as patients can develop life-threatening reactions to small exposures of peanut. Clinical trials of peanut oral immunotherapy, in which peanut allergic patients are given peanut to induce tolerance, induce lasting tolerance in only a subset of patients. Our project focuses on understanding how antibodies induced in these patients with tolerance have a unique ability to bind to the allergen to suppress allergic reactions and contribute to the development of long- lived tolerance after peanut oral immunotherapy.

PI_NAMEs: PATIL, SARITA U (contact)

PROGRAM_OFFICER_NAME: DONG, GANG

PROJECT_TERMS: Address;Affect;Affinity;Allergens;Allergic;Allergic Reaction;Allergy to peanuts;Anaphylaxis;Antibodies;Antibody Binding Sites;Antibody Therapy;Antigens;B-Cell Antigen Receptor;B-Lymphocytes;Basophils;Binding;Biological Markers;Cell surface;Characteristics;Clinical;clinical efficacy;Clinical Trials;clinically relevant;Cloning;cohort;crosslink;Data;desensitization;Development;Disease;Dose;Effector Cell;Epitopes;FDA approved;fitness;Flow Cytometry;food allergen;Food Hypersensitivity;Goals;IgE;IgG4;Immunoglobulin G;In Vitro;in vivo;Individual;Life;Life Experience;Light;lonely individuals;mast cell;Mediating;Memory B-Lymphocyte;mouse model;novel therapeutic intervention;novel therapeutics;Oral Characters;oral immunotherapy;Passive Cutaneous Anaphylaxis;patient subsets;Patients;Population;Positioning Attribute;Prevalence;prevent;Public Health;Reaction;receptor;Recombinant Antibody;response;Risk;Role;Serum;Site-Directed Mutagenesis;Specificity;Supervision;Testing;Work

PROJECT_TITLE: Structural and functional characterization of protective antibodies induced in peanut oral immunotherapy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IMM-T(57)S]


NIH_SPENDING_CATS: Cancer;Emerging Infectious Diseases;Genetics;HIV/AIDS;Hematology;Infectious Diseases;Lymphatic Research;Lymphoma;Pediatric;Pediatric Cancer;Rare Diseases

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Project Narrative Kaposi’s sarcoma-associated herpesvirus (KSHV) has an etiologic role in several human cancers. KSHV infects tumor cells and persists in these cells in a latent state. This work investigates the mechanisms this virus uses to allow it to be maintained in cells since a better understanding of these mechanisms may allow development of strategies which prevent KSHV cancers.

PI_NAMEs: KAYE, KENNETH M (contact)

PROGRAM_OFFICER_NAME: ALARCON, RODOLFO M

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;adult leukemia;Africa South of the Sahara;ASH2L gene;Binding;Biochemical;Biology;Cell division;Cell Nucleus;Cell Proliferation;Cell Survival;Cells;Childhood Leukemia;ChIP-seq;Chromatin;Chromatin Remodeling Factor;Chromosomes;Complex;Daughter;daughter cell;Deposition;Development;DNA biosynthesis;Epidemic;Epigenetic Process;Episome;Etiology;experimental study;Family;gammaherpesvirus;Gene Expression;Genes;Genetic;Genetic Transcription;Genome;Herpesviridae Infections;Histone H3;histone methylation;histone methyltransferase;Human;Human Herpesvirus 8;Immunocompromised Host;in vivo;Individual;Infection;insight;Kaposi Sarcoma;Knockout Mice;latency-associated nuclear antigen;Link;Lysine;Lytic;Maintenance;Malignant Neoplasms;Mammals;Mediating;Methylation;Mitosis;Mixed-Lineage Leukemia;Modification;Multicentric Angiofollicular Lymphoid Hyperplasia;Mus;N-terminal;neoplastic cell;novel;Oral cavity;Organ;prevent;primary effusion lymphoma;Proliferating;promoter;Proteins;recruit;Regulation;Role;Saliva;segregation;SET Domain;Site;Structure;Transcriptional Regulation;transcriptome sequencing;transmission process;tumor;Viral;Viral Genes;Viral Genome;Viral Proteins;Virus;Virus Diseases;Virus Latency;Visceral;Work

PROJECT_TITLE: KSHV Latency Regulation

STUDY_SECTION: HCAC

STUDY_SECTION_NAME: HIV Coinfections and HIV Associated Cancers Study Section[HCAC]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Genetics

ORG_CITY: KINGSTON

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF RHODE ISLAND

ORG_STATE: RI

PHR: PROJECT NARRATIVE SWI/SNF plays critical roles in many cellular processes, from response to environmental stress, to differentiation and development. However, mis-regulation of this complex causes cancers. The goal of this proposal is to understand how environmental stress, specifically hypoxia which is present in tumors, mediates changes in compositional variation of SWI/SNF and uses different forms of SWI/SNF for gene expression during hypoxia. Given loss of SWI/SNF units result in many cancers that form solid tumors with hypoxic centers, our studies will help understand the underlying mechanisms of how SWI/SNF functions as a tumor suppressor.

PI_NAMEs: DUTTA, ARNOB  (contact)

PROGRAM_OFFICER_NAME: CHOW, CHI-WING

PROJECT_TERMS: 3-Dimensional;Acute;Address;Affect;Architecture;ARID1A gene;Attention;Biochemical;Biological;Biological Process;Cancer Etiology;Cell Hypoxia;Cell Physiology;Cells;Chromatin;Chromatin Remodeling Factor;Chromatin Structure Alteration;Complement;Complex;Cues;Data;Dependence;deprivation;Development;Disease;disease-causing mutation;Down-Regulation;Enhancers;environmental change;Equilibrium;Event;Family;Gene Expression;Gene Expression Regulation;Genes;Genetic Transcription;Genomics;Goals;Human;Hypoxia;innovation;insight;Investigation;Knowledge;Maintenance;Malignant Neoplasms;Mediating;member;Modeling;Molecular;Multienzyme Complexes;Mutate;Mutation;Normal Cell;Nuclear;Nuclear Protein;Output;Oxygen;Pathway interactions;Physiological;Play;promoter;Protein Isoforms;Proteins;Regulation;Research;response;Role;Signal Transduction;skills;Solid Neoplasm;spheroids;stem cell niche;Stimulus;stoichiometry;Stress;SWI/SNF Family Complex;three dimensional cell culture;Time;tumor;Tumor Suppressor Proteins;Variant

PROJECT_TITLE: Regulation of SWI/SNF chromatin remodeler composition and function.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MGG-X (81)]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biotechnology;Immunization;Infectious Diseases;Malaria;Malaria Vaccine;Orphan Drug;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases

PHR: The proposal aims to dissect and define the correlates of immunity that track with protection from malaria infection following irradiated sporozoite vaccination as well as dissect the role of pre-existing immunity in shaping these vaccine-induced immune responses.

PI_NAMEs: BATISTA, FACUNDO DAMIAN (contact)

PROGRAM_OFFICER_NAME: MO, ANNIE X  Y

PROJECT_TERMS: Affinity;African;Anti-malarials;Antibodies;Antibody Formation;Antibody-mediated protection;Antigen Targeting;Antigens;antimicrobial;Binding;Blood group antigen S;Cells;Cellular Immunity;Cessation of life;Child;Clinical;Complement;Complement Receptor;Complex;Data;design;Development;Disease;disorder risk;Dissection;drug distribution;Drug resistance;Effector Cell;efficacy study;Fc Receptor;field study;follow-up;Hepatic;Human;Immune;Immune response;Immunity;Immunization;In Vitro;Individual;Infant;Infection;Infection prevention;Innate Immune System;Insecticides;insight;Knowledge;Liver;Macrophage;Malaria;malaria infection;Malaria Vaccines;Mediating;Modeling;Monoclonal Antibodies;mortality;Mosquito Control;Mosquito-borne infectious disease;Natural Killer Cells;Nature;neutrophil;next generation;novel;novel vaccines;Parasite resistance;Parasites;pathogen;Pattern;Phagocytosis;phase II trial;phase III trial;Plasmodium;Play;Populations at Risk;programs;recruit;response;Role;Sampling;Serology;Shapes;Specificity;Sporozoite vaccine;Sporozoites;synergism;System;Vaccination;Vaccine Design;vaccine development;vaccine evaluation;vaccine immunogenicity;vaccine platform;vaccine response;vaccine trial;vaccine-induced immunity;Vaccinee;Vaccines

PROJECT_TITLE: Defining functional humoral correlates of immunity to guide vaccine design

STUDY_SECTION: VMD

STUDY_SECTION_NAME: Vaccines Against Microbial Diseases Study Section[VMD]


ORG_CITY: CANANDAIGUA

ORG_NAME: VETERANS AFFAIRS, UNITED STATES DEPARTMENT OF

ORG_STATE: NY

PHR: Romantic relationship distress is a common impairment for Veterans screening positive for depression, posttraumatic stress disorder, or alcohol misuse in primary care. Relationship distress also serves as a prominent suicide risk factor. The Brief Relationship Checkup (BRC) is a three 30-minute session treatment that helps couples make concrete commitments to improve their relationships. We propose a pilot randomized controlled trial of BRC in 72 distressed couples (N=144 individuals) where at least one partner is a Veteran screening positive on a primary care mental health screen. Couples will be randomized to BRC or to three sessions of the Co-Located Collaborative Care model (CCC; the standard of care for primary care mental health). Couples will be re-assessed at post-treatment, 3-months, and 6-months. The results will provide the foundations for a larger trial by determining BRC’s efficacy in improving relationship-level and individual-level risk/protective factors for suicide. Finally, we will develop a fidelity codebook to operationalize BRC adherence and competence.

PI_NAMEs: CRASTA, DEV J (contact)

PROJECT_TERMS: acceptability and feasibility;active duty;Address;Adherence;Aftercare;Air;alcohol misuse;associated symptom;career;Caring;checkup examination;Clinical Trials;collaborative care;community clinic;Competence;Couples;Couples Therapy;Data;depressive symptoms;design;Distress;Elements;experience;Family;Feeling suicidal;Foundations;Functional disorder;Funding;Goals;help-seeking behavior;high risk;Impaired health;Impairment;improved;indexing;Individual;innovation;Intervention;Learning;Manuals;Marriage;Measures;Mental Depression;Mental Health;Mental Health Services;Modeling;motivational enhancement therapy;open label;Participant;pilot trial;Policies;Population;Post-Traumatic Stress Disorders;Prevention;Prevention approach;Prevention strategy;Primary Care;programs;protective factors;Psychotherapy;Randomized;Randomized, Controlled Trials;recruit;reducing suicide;Reporting;Research;Research Project Grants;Risk;Risk Factors;Risk Management;Sampling;satisfaction;Science;screening;selective prevention;service member;standard of care;Strategic Planning;Structure;suicidal morbidity;suicidal risk;Suicide;Suicide prevention;Symptoms;Techniques;Telephone;Testing;Time;Training;treatment effect;Validation;Value of Life;Veterans;Veterans Health Administration

PROJECT_TITLE: Supporting Relationships to Reduce Suicide Risk: A Randomized Control Trial of the Brief Relationship Checkup

STUDY_SECTION_NAME: Career Development Program - Panel II[RRD9]


ORG_NAME: VETERANS HEALTH ADMINISTRATION

PHR: Veterans with mild traumatic brain injury (mTBI) and post-traumatic stress disorder (PTSD) commonly experience cognitive impairments including attention and executive function deficits that interfere with their ability to engage in productive personal and social activities. Of the limited interventions available to address cognition, none rigorously train attention beyond strategy management. This study will evaluate an innovatively combined strategy training known as Goal Management Training plus computerized attention training in Veterans with mTBI/PTSD. Preliminary testing suggests an effectiveness in improving problem solving, attention and functional tasks in a small number of Veterans. Considering these promising results, cost effectiveness, and the demand for access to care from Veterans living in rural areas, a Randomized Controlled Trial will determine and compare the effects of this treatment, administered either in-person or via telehealth, on executive function, attention, other aspects of cognition and real life functional tasks.

PI_NAMEs: WAID-EBBS, JULIA KAY (contact)

PROJECT_TERMS: Address;Aftercare;Attention;Awareness;brain control;brain health;Caring;Clinical;clinical practice;Cognition;Cognitive;cognitive control;cognitive process;cognitive rehabilitation;Combined Modality Therapy;comorbidity;compare effectiveness;Complex;computerized;Control Groups;cost effectiveness;Cost Savings;COVID-19 pandemic;current pandemic;Data;Department of Defense;directed attention;Disabling;Dissociation;Educational workshop;Effectiveness;Evaluation;Executive Dysfunction;executive function;experience;flexibility;Goals;health goals;Health Services Accessibility;Healthcare Systems;Hour;Impaired cognition;Impairment;improved;indexing;innovation;instrument;Intervention;Life;Measures;Methods;mild traumatic brain injury;Military Personnel;military veteran;neurobehavioral;Neuropsychology;novel;Outcome;pandemic disease;Performance;Persons;Pilot Projects;Population;Post-Traumatic Stress Disorders;Prediction of Response to Therapy;Problem Solving;Process;Productivity;Protocols documentation;Psyche structure;Quality of Care;Quality of life;Randomized;randomized, controlled study;Randomized, Controlled Trials;Recommendation;Regimen;Rehabilitation therapy;Reporting;Research;Research Design;response;rural area;Services;Shapes;Short-Term Memory;skills;social;systematic review;Task Performances;telehealth;Testing;Training;Translating;Translations;treatment effect;Treatment outcome;treatment response;treatment strategy;United States Department of Veterans Affairs;United States National Institutes of Health;Veterans;Veterans Health Administration;Work

PROJECT_TITLE: Comparing the effectiveness of telehealth to in-person delivery of a combined metacognitive and attention training in Veterans with mTBI/PTSD

STUDY_SECTION_NAME: Brain Health and Injury[RRD1]


ORG_CITY: BEDFORD

ORG_NAME: EDITH NOURSE  ROGERS MEMORIAL VETERANS HOSPITAL

PHR: As Veterans age, chronic health conditions increase their risk of functional limitations, or difficulty completing day-to-day activities independently. Older adults with functional limitations are more likely to be hospitalized or admitted to long-term care facilities. Maintaining independence at home and in the community is a high priority for many older Veterans. However, there are few existing interventions focused on helping older Veterans maintain their independence, and they rarely target multiple areas of functioning (e.g. physical, cognitive, and social). The goal of this CDA-2 proposal is to support the physical, cognitive, and social functioning of older Veterans by developing a program based on behavioral activation, an evidence-based brief psychosocial intervention that helps individuals increase their engagement in activities aligned with their values (i.e. what matters most to them). This project will simultaneously support the career development of the candidate into an independent VA researcher focused on promoting functional independence in older Veterans.

PI_NAMEs: KENNEDY, MEAGHAN A. (contact)

PROJECT_TERMS: Activities of Daily Living;acute care;Address;Adherence;Admission activity;adverse outcome;Age;age related chronic disease;Aging;Area;attentional control;Award;Behavioral;behavioral health;Behavioral Model;Behavioral Sciences;behavioral study;brief intervention;Cancer Survivor;career;career development;Caring;Chronic;Clinical;Clinical Trials Design;Cognition;Cognitive;cognitive function;Communities;Complex;Data;design;Development;diagnostic strategy;disability;Disease;Education;effective intervention;efficacy trial;Elderly;Enrollment;Etiology;evidence base;Evidence based intervention;experience;Feedback;follow-up;functional decline;functional independence;Funding;Future;Geriatric Psychiatry;Geriatrics;Goals;Grant;Growth;Health;Health care facility;Home;Hospitalization;human old age (65+);Impaired cognition;improved;Individual;innovation;Intervention;Interview;Leadership;Life;Linear Regressions;Long-Term Care;Manuals;Measures;Mental Depression;Mentors;Methodology;Methods;mild cognitive impairment;Mission;Modeling;mortality;multiple chronic conditions;novel;Occupational Therapist;Occupational Therapy;older adult;Outcome;Participant;Physical Function;Physicians;Pilot Projects;pilot test;pilot trial;preservation;Primary Care;primary outcome;programs;Prospective Studies;Protocols documentation;Psychologist;psychosocial;Psychosocial Assessment and Care;Randomized;recruit;rehabilitation science;Rehabilitation therapy;Reporting;Research;Research Personnel;Risk;Role;Rural;Sampling;satisfaction;social;Social Controls;Social Functioning;Social isolation;Structure;Surveys;Target Populations;Techniques;telehealth;Testing;therapy development;Training;trend;United States National Institutes of Health;Veterans;Work;Writing

PROJECT_TITLE: Development and Feasibility of a Behavioral Activation Intervention to Support Independence in Older Veterans at Risk for Functional Decline