NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Prevention;Social Determinants of Health

PI_NAMEs: PACHANKIS, JOHN EDWARD (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;AIDS prevention;anti-racism;Applications Grants;Area;career;career development;career networking;Collaborations;Communities;community engaged research;comorbidity;Dedications;Development;digital health;education research;Ensure;environmental enrichment for laboratory animals;Epidemic;Equity;Feedback;Fostering;Funding;Grant;Grant Review;health determinants;health equity;Health Services Research;high risk;HIV;HIV disparities;HIV Infections;implementation science;Incidence;Inequity;innovation;Interdisciplinary Study;International;Lived experience;Locales;low and middle-income countries;Malaysia;Manuscripts;marginalization;marginalized population;Mental Health;Mentors;Mentorship;Methods;Mission;New England;next generation;Outcome;peer;Peer Review;Pilot Projects;Policies;Population;Postdoctoral Fellow;pre-doctoral;Prevalence;Prevention;Program Reviews;programs;Public Health Schools;Research;research and development;Research Personnel;Research Priority;Research Support;Research Training;Resources;Role;scale up;Scholars Program;Science;Scientist;Services;social health determinants;Social Justice;Structure;Substance Use Disorder;Support System;System;Training;Training Programs;Uganda;urban area;Vision;Visit

PROJECT_TITLE: Development Core


ADMINISTERING_IC: DK

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Kidney Disease;Patient Safety;Prevention

ORG_CITY: NEW YORK

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: PROJECT NARRATIVE Patients initiating hemodialysis are at significantly higher risk of morbidity and mortality than age- and sex- matched patients from the general population. Empagliflozin, a sodium-glucose co-transporter 2 inhibitor, has been shown to reduce cardiovascular risk, heart failure, and to slow kidney function decline in patients with kidney disease, but the safety and efficacy of this therapy among patients with kidney failure initiating hemodialysis is not clear. We propose a pilot randomized placebo-controlled clinical trial to evaluate the safety and efficacy of empagliflozin in patients initiating hemodialysis and thereby inform the design of a larger multi- center study to evaluate hard clinical outcomes.

PI_NAMEs: CHARYTAN, DAVID M (contact);MCCAUSLAND, FINNIAN R

PROGRAM_OFFICER_NAME: CHAN, KEVIN E

PROJECT_TERMS: absorption;Acute;Address;Adult;Adverse effects;Adverse event;Age;Albumins;Attenuated;Binding Proteins;Biological;Blood Pressure;Body Water;Cardiovascular Diseases;cardiovascular risk factor;Cardiovascular system;Cause of Death;Cessation of life;Chronic Kidney Failure;Clinical;Clinical Trials;clinically relevant;Coronary Arteriosclerosis;Creatinine clearance measurement;Data;Death Rate;Dedications;design;Development;Diabetes Mellitus;Disease Progression;Diuresis;End stage renal failure;Equipoise;Event;Exclusion;Excretory function;experience;Feedback;Fluid overload;Frequencies;functional decline;Functional disorder;General Population;Genitalia;Genitourinary System Infection;Glucose;glycemic control;Guidelines;Heart failure;heart rate variability;Hemodialysis;hemodynamics;High Prevalence;high risk;high risk population;Hospitalization;Hour;Hypertension;Hypoglycemia;Hypotension;improved;Incidence;Individual;Infection;inhibitor;innovation;Kidney;Kidney Diseases;Kidney Failure;Knowledge;Literature;Maintenance;Mediating;Metabolism;Morality;Morbidity - disease rate;mortality;mortality risk;Multicenter Studies;Nephrology;novel therapeutic intervention;novel therapeutics;Outcome;Patient Care;Patient Readmission;Patients;Performance;Pharmaceutical Preparations;Phase;Physiological;Pilot Projects;pilot trial;Placebo Control;Placebos;Population;preservation;prevent;protein distribution;Proteinuria;Proximal Kidney Tubules;Randomized;randomized placebo-controlled clinical trial;Renal function;Renin-Angiotensin System;Reporting;Residual state;Risk;Risk Factors;Risk Reduction;Safety;safety testing;sex;Sodium;symporter;Testing;Treatment Efficacy;United States;Urea;urinary;Urine;Weight

PROJECT_TITLE: Safety and Efficacy of Empagliflozin Main intenance HD (SEED)

STUDY_SECTION: KUFD

STUDY_SECTION_NAME: Kidney and Urological Systems Function and Dysfunction Study Section[KUFD]


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Hepatitis;Liver Disease;Nutrition;Obesity

ORG_CITY: LEXINGTON

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: With the epidemic burden of obesity and metabolic diseases, non-alcoholic fatty liver disease (NAFLD) is becoming one of the most common hepatic diseases worldwide. Our project proposes to study the mechanisms underlying liver macrophage pro-inflammatory activation and the contribution of this process to NAFLD development and progression. Knowledge gained from our studies may lead to novel therapeutic strategies in the treatment of obesity-associated NAFLD/NASH.

PI_NAMEs: WANG, SHUXIA  (contact)

PROGRAM_OFFICER_NAME: LOH, KATRINA SHUEH WEN

PROJECT_TERMS: 3-Dimensional;Acids;Affect;Animal Model;Animals;Attenuated;Back;Binding;CD36 Antigens;CD36 gene;Cell membrane;Ceramides;chronic liver disease;cytokine;Data;Development;Diet;Disease;Disease Progression;Down-Regulation;Epidemic;Fatty Liver;Feedback;Feeds;Fibrosis;GPI Membrane Anchors;Human;In Vitro;in vitro Model;in vivo;Infiltration;Inflammation;Inflammatory;knock-down;Knock-out;Knowledge;Kupffer Cells;Lipids;Liver;Liver diseases;Liver Fibrosis;Macrophage;Macrophage Activation;Maps;Mediating;Membrane Lipids;Membrane Microdomains;Membrane Proteins;Metabolic Diseases;Modeling;Modification;monocyte;mouse model;nanoparticle;new therapeutic target;non-alcoholic fatty liver;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;novel;novel therapeutic intervention;novel therapeutics;Obesity;obesity treatment;Organoids;overexpression;Pathogenesis;Pathway interactions;Patients;Peptides;peripheral blood;Phenotype;Process;Production;Proteins;receptor;recruit;Reducing diet;Risk Factors;Rodent;Role;Signal Transduction;Sphingomyelinase;targeted treatment;Testing;Therapeutic;therapy development;Thrombospondin 1;TLR4 gene;Western World

PROJECT_TITLE: Role of SMPDL3B in obesity-associated  non-alcoholic fatty liver disease

STUDY_SECTION: XNDA

STUDY_SECTION_NAME: Xenobiotic and Nutrient Disposition and Action Study Section[XNDA]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biomedical Imaging;Cardiovascular;Clinical Research;Heart Disease;Lung;Neonatal Respiratory Distress;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Pulmonary Hypertension

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: Project Narrative: Children and adults born extremely premature (<28 weeks gestational age) are 17 times more likely to develop heart failure by early adulthood, yet the reasons and rate of progression are poorly understood. This study will develop cardiac growth and function trajectories, with the expectation to identify poor cardiac growth and accelerated rates of functional decline in children and adults born preterm. Study results will provide justification for future early intervention studies to promote cardiac growth and preserve cardiac function after preterm birth.

PI_NAMEs: GOSS, KARA N (contact)

PROGRAM_OFFICER_NAME: PEMBERTON, VICTORIA

PROJECT_TERMS: Acceleration;Adolescence;Adolescent;Adult;Affect;Age;age group;age related decline;Biological Markers;Blood Vessels;Bronchopulmonary Dysplasia;Cardiac;cardiac magnetic resonance imaging;Cardiopulmonary;cardiovascular effects;cardiovascular health;Cardiovascular system;Characteristics;Child;Childhood;Chronology;Cohort Studies;coronary fibrosis;Coupling;Data;Databases;Disease;disease natural history;Early Intervention;Echocardiography;EFRAC;emerging adult;Equation;Evaluation;Exercise;expectation;extreme prematurity;Failure;falls;Female;Fibrosis;functional decline;Future;Gadolinium;Gestational Age;Growth;Heart;heart dimension/size;Heart failure;heart function;heart preservation;High Prevalence;high risk;Impairment;improved;indexing;Individual;Injury;Intervention;Intervention Studies;Knowledge;Left;Left Ventricular Mass;life span;Live Birth;Lung;Magnetic Resonance Imaging;male;Maps;Measures;Modeling;Myocardium;Neonatal;neonatal exposure;Neonatal Intensive Care Units;neonatal resuscitation;novel;Population Heterogeneity;preclinical study;Pregnancy;Premature Birth;Process;prospective;Pulmonary artery structure;Pulmonary function tests;Pulmonary Hypertension;pulmonary vascular disorder;Race;recruit;Registries;Research;Right Ventricular Dysfunction;Right Ventricular Function;Risk;Risk Factors;screening;Serum;sex;socioeconomics;Stroke Volume;Structure;Systemic hypertension;Time;Vascularization;Ventricular;Ventricular End-Diastolic Volumes;young adult

PROJECT_TITLE: Cardiac Growth and Function Trajectories after Preterm Birth

STUDY_SECTION: CCHS

STUDY_SECTION_NAME: Clinical Integrative Cardiovascular and Hematological Sciences Study Section[CCHS]


ADMINISTERING_IC: AG

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Physical Activity;Prevention;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: NARRATIVE Progressive difficulty in performing everyday functional activities is a key diagnostic feature of dementia syndromes, but little is known about the neural signature of functional decline, particularly during the very early stages of dementia. We apply a novel neurophysiological approach to measure brain activation during complex gait based functional tasks to establish a biomarker and predictor of functional decline during the preclinical dementia period before overt impairment is observed. Establishing the clinical relevance and biological basis of the neural signature of functional decline will improve early detection and maintain functional abilities, independence, and quality of life in older adults at-risk for dementia.

PI_NAMEs: DE SANCTIS, PIERFILIPPO  (contact)

PROGRAM_OFFICER_NAME: ST  HILLAIRE-CLARKE, CORYSE

PROJECT_TERMS: Accelerometer;Activities of Daily Living;Affect;Alzheimer's Disease;Alzheimer’s disease biomarker;Amyloid beta-Protein;Behavior;Biological;Biological Markers;Blood Vessels;Brain;Brain Pathology;brain volume;clinical predictors;clinically relevant;Cognition;Cognitive;cognitive performance;cognitive testing;cohort;Communities;Complex;daily functioning;Dementia;dementia risk;Diagnostic;Early Diagnosis;Early Intervention;Eating;Elderly;Electroencephalography;Enrollment;Exercise;Frequencies;functional decline;Gait;Goals;imaging biomarker;Impaired cognition;Impairment;improved;in vivo;Incidence;Individual;Intervention;Link;Magnetic Resonance Imaging;magnetic resonance imaging/electroencephalography;Maps;Measures;Medial;Medication Management;mental state;mild cognitive impairment;motor control;neural;neural patterning;neurophysiology;novel;novel marker;observational cohort study;older adult;Participant;Pathology;Patient Self-Report;Patients;Pattern;Physical activity;Physical activity scale;Physical Exercise;physical inactivity;Plasma;Population;portability;pre-clinical;Prevalence;prospective;Protocols documentation;Quality of life;Questionnaires;recruit;Reporting;Research;Risk;Self Assessment;Source;Sterile coverings;Syndrome;Testing;walking speed;White Matter Hyperintensity;Work

PROJECT_TITLE: Linking dementia pathology and alteration in brain activation to complex daily functional decline during the preclinical dementia stage

STUDY_SECTION: ASG

STUDY_SECTION_NAME: Aging Systems and Geriatrics Study Section[ASG]


ADMINISTERING_IC: MH

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Prevention;Social Determinants of Health

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PI_NAMEs: NELSON, LARON EARNEST (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Advocacy;AIDS prevention;anti-racism;Area;Black race;Caring;Church;Clinic;cohort;Collaborations;Communities;community engaged research;community organizations;community partners;community partnership;community research;Consultations;County;Critical Race Theory;Dedications;design;Development;Discrimination;Educational Curriculum;Effectiveness;Epidemic;epidemic response;Equity;Ethics;Evidence based intervention;Fostering;Gays;Goals;Health;health equity;High Prevalence;HIV;HIV prevention trials network;HIV/AIDS;Housing;Human;implementation determinants;implementation research;implementation science;implementation strategy;Individual;innovation;Interdisciplinary Study;intersectionality;Intervention;Justice;Knowledge;Leadership;Learning;lens;men who have sex with men;Methods;Mission;Movement;New England;outreach;Participant;Policies;Population;Positioning Attribute;prevent;prevention service;Prisons;Process;programs;Public Health;queer;Research;Research Personnel;Research Priority;response;Science;Scientific Advances and Accomplishments;Scientist;service organization;Services;skills;Social Justice;social norm;Social Sciences;social stigma;theories;tool;Training;treatment services;urban area;urban setting;Work

PROJECT_TITLE: Justice, Community, Capacity & Equality


ADMINISTERING_IC: HG

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Data Science;Genetics;Human Genome

ORG_CITY: BALTIMORE

ORG_DEPT: GENETICS

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Now in its 55th year, Online Mendelian Inheritance in Man (OMIM) is a foundational resource, a knowledgebase of human genes and genetic disorders and traits that is accessed annually by over 2.7 million unique users worldwide. Its core mission is (1) describing, naming, and classifying genetic diseases, and (2) providing easily accessible and computable information on gene-disease relationships through rich, structured text, brief clinical synopses, and a table that tracks the progress of disease-gene discovery. Expert MD- and PhD- biocurators review and summarize information from the biomedical literature to create this authoritative, comprehensive and timely resource that is essential for the practice of medicine, and directly advances basic, translational, and clinical research, as well as therapeutic discovery.

PI_NAMEs: HAMOSH, ADA  (contact)

PROGRAM_OFFICER_NAME: MINEAR, MOLLIE A

PROJECT_TERMS: Aloral;analysis pipeline;Basic Science;Bibliography;Bioinformatics;Catalogs;Chromosome Deletion;Classification;Clinical;Clinical Medicine;Clinical Research;ClinVar;Collaborations;Communication;Communities;Complex;Computerized Patient Records;Controlled Vocabulary;cost effective;Data;data access;data harmonization;data integration;data mining;data resource;data visualization;Databases;Discipline;Disease;disease classification;Doctor of Philosophy;Documentation;Ensure;Evaluation;experience;Fast Healthcare Interoperability Resources;Feedback;FlyBase;gene discovery;Genes;Genetic;Genetic Diseases;Genome;genome resource;genome sciences;Genomics;Goals;Health Personnel;Human;Human Biology;human disease;Human Genetics;human genomics;improved;Industry;International;Internet;Knowledge;knowledgebase;Literature;man;Maps;Medical Genetics;Medicine;Mendelian disorder;Mission;model organism;model organisms databases;Molecular;Names;Online Mendelian Inheritance In Man;Ontology;Peer Review;Persons;Phenotype;Pilot Projects;Process;Production;Protein Databases;Publishing;Reporting;Research;Research Personnel;Resource Informatics;Resources;Science;Scientist;search engine;Series;software development;Structure;Students;Surveys;Syndrome;Systematized Nomenclature of Medicine;teacher;Technology;Terminology;Text;Therapeutic;tool;Training;trait;Translational Research;Unified Medical Language System;Universities;Update;Variant;web services;web site;WormBase

STUDY_SECTION: GNOM

STUDY_SECTION_NAME: Genome Research Study Section[GNOM-G]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Lung;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Radiation Oncology

ORG_CITY: ATLANTA

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative Stereotactic body radiotherapy (SBRT) highly requires precise radiation delivery in the presence of tumor motion to eradicate tumors with highly potent dose while minimizing normal tissue dose to reduce treatment toxicity. Our proposed study aims to develop a real-time volumetric imaging-based tumor tracking and dose verification system for lung photon SBRT that will substantially improve treatment accuracy and precision and guarantee high treatment quality throughout the entire treatment course. This system is expected to revolutionize the current clinical practice of lung radiotherapy, and can be adopted for a wide range of clinical applications and easily adapted for liver and pancreas SBRT.

PI_NAMEs: TIAN, ZHEN ;YANG, XIAOFENG  (contact)

PROGRAM_OFFICER_NAME: WANG, YISONG

PROJECT_TERMS: 3-Dimensional;Abdomen;Address;Adopted;Algorithms;Anatomy;Area;Articular Range of Motion;Artificial Intelligence;automated segmentation;Biometry;cancer radiation therapy;cancer site;cancer therapy;Clinical;clinical application;Clinical Data;clinical practice;Collimator;Compensation;convolutional neural network;cost;cost effective treatment;Data;deep learning;Development;Dose;dosimetry;Ensure;falls;generative adversarial network;Geometry;Image;imaging Segmentation;Implant;improved;Inferior;Inhalation;innovation;Interdisciplinary Study;Linear Accelerator Radiotherapy Systems;Liver;Location;long short term memory;Lung;Malignant neoplasm of lung;Masks;Medical;Methods;migration;Modernization;Monitor;Monte Carlo Method;Motion;Normal tissue morphology;novel;Organ;Pancreas;patient safety;Patients;Performance;Photons;Physicians;Physics;Plant Leaves;Radiation;radiation delivery;Radiation Dose Unit;Radiation Oncology;Radiation therapy;Reproducibility;Respiration;respiratory;Risk;simulation;Site;success;Supervision;System;Techniques;Technology;Testing;Three-Dimensional Image;Time;Tissues;Treatment outcome;Treatment-related toxicity;tumor;tumor eradication;Tumor Volume;Uncertainty;X-Ray Computed Tomography;X-Ray Medical Imaging

PROJECT_TITLE: Real-time Volumetric Imaging for Motion Management and Dose Delivery Verification

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Mental Health;Prevention;Social Determinants of Health

PI_NAMEs: EDELMAN, E. JENNIFER (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;AIDS prevention;anti-racism;Attention;Behavioral;Buprenorphine;Caring;Clinical;Clinical effectiveness;Clinical Services;Collaborations;Communities;community based participatory research;comorbidity;Continuity of Patient Care;COVID-19;Criminal Justice;Development;digital health;disability;Disparity;dissemination science;Ensure;Epidemic;Equity;Ethnic Origin;Evaluation;experience;flexibility;fluidity;Formulation;Fostering;Gender;Health;health equity;Health Promotion;Health Services;Health Services Research;HIV;HIV/AIDS;Household;Housing;Human;implementation intervention;implementation research;implementation science;improved;Individual;Injectable;innovation;insight;Interdisciplinary Study;International;Intervention;Intervention Studies;Justice;Labor Forces;lens;marginalization;Mental disorders;Mental Health;Methods;Movement;multidisciplinary;National Institute of Mental Health;New England;novel;opioid use disorder;Persons;Population;Poverty;pre-exposure prophylaxis;prevention service;Process;Race;Research;Research Methodology;Research Personnel;Research Support;response;Risk;rural-urban migration;sex trafficking;sexual exploitation;sexual identity;social;social health determinants;substance use;substance use treatment;System;Time;treatment services;uptake;Vulnerable Populations

PROJECT_TITLE: Clinical Health Services and Research Core


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Drug Abuse (NIDA only);Electronic Nicotine Delivery Systems;Harm Reduction for Substance Misuse;Health Services;Lung;Lung Cancer;Opioid Misuse and Addiction;Opioids;Prevention;Substance Misuse;Telehealth;Tobacco;Tobacco Smoke and Health

PHR: PROJECT NARRATIVE Persons with opioid use disorder in methadone and buprenorphine treatment programs are a very vulnerable population with exceptionally high combustible cigarettes smoking burden and yet limited success in achieving meaningful clinical outcomes in tobacco treatment. We propose an open-label, randomized controlled trial to compare the effect of electronic cigarettes to combination nicotine replacement therapy on combustible cigarettes smoking reduction. If effective, electronic cigarettes would provide an additional tool for tobacco harm reduction among this difficult-to-treat vulnerable population.

PI_NAMEs: EL-SHAHAWY, OMAR  (contact)

PROGRAM_OFFICER_NAME: HERRMANN, EVAN SULLIVAN

PROJECT_TERMS: 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol;Abstinence;Address;Adherence;Adult;arm;Behavior;Behavioral;buprenorphine treatment;Carbon Monoxide;Caring;cigarette smoke;Cigarette Smoker;cigarette smoking;Clinical;combustible cigarette;Counseling;Databases;Dependence;Ecological momentary assessment;Effectiveness;Effectiveness of Interventions;effectiveness testing;Electronic cigarette;electronic cigarette use;Electronic Health Record;evidence base;Exhalation;experience;follow-up;Goals;Harm Reduction;Health;health related quality of life;improved;interest;Intervention;Long-Term Care;Measures;Mediating;meetings;methadone treatment;Modeling;Motivation;National Institute of Drug Abuse;New York City;Nicotine;nicotine replacement;Nicotine Withdrawal;novel;open label;Opioid;opioid use disorder;Outcome;Participant;Patient Recruitments;Patient Self-Report;Pattern;Perception;Persons;Pharmaceutical Preparations;Policies;preference;Premature Mortality;primary outcome;Protocols documentation;Provider;pulmonary function;Quality of life;Randomized, Controlled Trials;recruit;Regulation;Relapse;Research;Respiratory Signs and Symptoms;Ritual compulsion;Sampling;secondary outcome;Self Efficacy;skills;Smoker;Smoking;smoking cessation;smoking exposure;success;Surveys;Target Populations;telehealth;Time;Tobacco;Tobacco use;Tobacco-Associated Carcinogen;tool;Toxicant exposure;Training;treatment arm;treatment program;Urine;Variant;Vulnerable Populations

PROJECT_TITLE: Effectiveness and impact of counseling enhanced with electronic cigarettes for harm reduction in smokers with opioid use disorder

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Breast Cancer;Cancer;Clinical Research;Lymphatic Research;Lymphedema;Prevention;Women's Health Research

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: Project Narrative Lymphedema, which is symptomatic swelling caused by damage of the lymphatic system commonly caused by cancer treatment, can have devastating and permanent clinical and financial consequences for patients. We propose developing a noninvasive, MRI-based, clinically- translational technique that can provide anatomic maps of the lymphatic system in vivo, enabling surgeons to plan surgery to avoid lymphatic damage. If successful, this method would potentially shift the entire paradigm of lymphedema management, from a current focus on therapy to one of prevention.

PI_NAMEs: TSAI, LEO LEE (contact)

PROGRAM_OFFICER_NAME: BARRY, ROBERT LEO II

PROJECT_TERMS: 3-Dimensional;Acceleration;Adoption;Affect;Agreement;Algorithms;Anatomy;Back;Breast Cancer survivor;Bypass;Cadaver;Cancer Etiology;cancer surgery;cancer therapy;Categories;Clinical;clinical application;clinical training;clinical translation;Cost of Illness;Data;deep learning;design;detection method;Development;Diagnostic radiologic examination;Diameter;Dissection;draining lymph node;Edema;Excision;Exclusion;experimental study;Goals;Hand;healthy volunteer;Human;Image;Imaging Techniques;in vivo;in vivo evaluation;Incidence;Individual;Indocyanine Green;Injections;Interdisciplinary Study;Knowledge;Label;Lead;Limb structure;Location;Lower Extremity;Lymph;Lymph Node Mapping;lymph nodes;Lymphangiography;Lymphatic;lymphatic drainage;lymphatic imaging;Lymphatic System;lymphatic vessel;Lymphedema;Lymphography;lymphoscintigraphy;Magnetic Resonance;Magnetic Resonance Imaging;Malignant Breast Neoplasm;Malignant Neoplasms;Maps;Measures;Medical Care Costs;Methods;multidisciplinary;novel;Operative Surgical Procedures;Pathway interactions;Patients;Penetration;Peripheral;Persons;Physiologic pulse;Positioning Attribute;Prevalence;prevent;Prevention;Preventive measure;programs;Progressive Disease;Protocols documentation;Quality of life;Reference Standards;repaired;Research;Research Personnel;Resolution;Risk;Scanning;Schedule;Scientist;Severities;Signal Transduction;simulation;Site;Surgeon;Swelling;targeted imaging;Techniques;Testing;Therapeutic;Time;Tissues;tool;trial design;ultrasound;Upper Extremity;Validation;Variant

PROJECT_TITLE: High-Resolution Lymphatic Mapping of the Upper Extremities with MRI

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: Program Narrative (Relevance) The DNA of our cells is frequently broken and must be faithfully repaired for life to continue. Failure of faithful DNA break-repair by genetic recombination leads to birth defects, infertility, and cancer. Inhibitors of DNA break-repair in bacteria can be developed into novel, sorely needed antibiotics to combat the ever-threatening emergence of drug-resistant bacteria.

PI_NAMEs: SMITH, GERALD R (contact)

PROGRAM_OFFICER_NAME: MACARTHUR, LINDA

PROJECT_TERMS: Achievement;Antibiotics;Area;Bacteria;Bacteriophage lambda;Biochemical;biophysical analysis;Cells;Centenarian;Chromosomal Rearrangement;Chromosome Segregation;Chromosomes;combat;Complex;Congenital Abnormality;Data;DNA;DNA analysis;DNA Double Strand Break;DNA Repair;drug resistant bacteria;Ensure;Enzymes;Escherichia coli;Exodeoxyribonuclease V;Failure;Fission Yeast;Fluorescence Microscopy;Generations;Genetic;genetic analysis;Genetic Recombination;Goals;Human;Infertility;inhibitor;Life;Malignant Neoplasms;Meiosis;Meiotic Recombination;model organism;Molecular;Molecular Analysis;mutant;novel;nuclease;Organism;Pathway interactions;programs;Protein Analysis;Proteins;repaired;Research;Site;three dimensional structure;Time

PROJECT_TITLE: Molecular analysis of genetic recombination and DNA break repair

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-S(55)R]


PI_NAMEs: HERNANDEZ, RAUL ULISES (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;AIDS prevention;anti-racism;Area;career;Caring;Cluster randomized trial;comorbidity;Consultations;Data;design;Development;Disparity;disparity reduction;Dissemination and Implementation;dissemination science;economic evaluation;effectiveness/implementation design;Epidemic;Equity;Ethnic Origin;Evaluation;Funding;Gender;Goals;health economics;health equity;HIV;HIV disparities;HIV/AIDS;implementation framework;implementation science;improved;Individual;Inequity;innovation;Interdisciplinary Study;interest;Knowledge;Learning;lens;Location;longitudinal analysis;marginalized population;mathematical model;Measures;Mental Health;Mentors;Methodology;Methods;multidisciplinary;multilevel analysis;multiphase optimization strategy;New England;next generation;novel;Operations Research;Peer Review;Pilot Projects;Play;Prevention;prevention service;Process;Program Acceptability;Public Health;Quasi-experiment;Race;Research;Research Design;Research Methodology;Research Personnel;Role;satisfaction;Science;Scientist;Sequential Multiple Assignment Randomized Trial;Services;Sexuality;substance use;Survival Analysis;Technical Expertise;Technology;theories;tool;Training;treatment services;Underrepresented Populations;urban area;webinar;Work

PROJECT_TITLE: Dissemination and implementation Science Methods


NIH_SPENDING_CATS: Cancer;Immunotherapy

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Project Narrative Targeting RAS/MAPK oncogenic signaling using RAF and MEK inhibitors has shown significant activity in cancer patients, but the antitumor effectiveness of these drugs is limited by adaptive resistance. Further, the effects of RAS/MAPK-targeted therapies on normal tissue, including the immune system, are largely unknown. Our goal is to study mechanisms of RAS regulation and adaptive resistance to MAPK inhibition, develop more effective pharmacologic combinatorial strategies for MAPK-dependent tumors and identify molecular determinants of response to these strategies that can be used as predictive biomarkers.

PI_NAMEs: POULIKAKOS, POULIKOS I (contact)

PROGRAM_OFFICER_NAME: FORRY, SUZANNE L

PROJECT_TERMS: Accounting;Adaptor Signaling Protein;Affect;Attenuated;Biochemical;BRAF gene;Breast Cancer Model;Cancer Patient;cancer type;cell killing;Cell Line;Cell Physiology;Cells;Cessation of life;checkpoint therapy;Clinical;Clinical effectiveness;Coculture Techniques;combinatorial;Combined Modality Therapy;Complex;Data;Dependence;design;Development;effective therapy;Effectiveness;engineered T cells;experimental study;Feedback;FGFR1 gene;Fibroblast Growth Factor Receptors;follow-up;Goals;growth factor receptor-bound protein 2;Human;Immune;Immune response;Immune system;Immunotherapy;improved;In Vitro;in vivo;inhibitor;insight;Knowledge;Malignant Neoplasms;MAP Kinase Gene;Mediating;MEKs;Melanoma;Methods;Mitogen-Activated Protein Kinase Inhibitor;Modeling;Molecular;mutant;Mutation;neoplastic cell;new technology;Normal Cell;Normal tissue morphology;novel;Oncogenic;Outcome;Pathway interactions;patient derived xenograft model;Patients;Pharmaceutical Preparations;pharmacologic;Phosphoric Monoester Hydrolases;Phosphorylation;PI3K/AKT;potential biomarker;pre-clinical;predictive marker;prevent;Protein Tyrosine Phosphatase;Proto-Oncogene Proteins c-akt;PTPN11 gene;RAS inhibition;Ras/Raf;rational design;Receptor Protein-Tyrosine Kinases;Regulation;Research Personnel;Resistance;response;Role;Signal Transduction;small molecule;small molecule inhibitor;Surrogate Markers;System;T-Lymphocyte;targeted treatment;Technology;Testing;Therapeutic;Therapeutic Index;treatment response;triple-negative invasive breast carcinoma;tumor;Tumor Tissue;Up-Regulation;Xenograft Model

PROJECT_TITLE: REGULATION AND ADAPTIVE MECHANISMS OF ONCOGENIC RAS/ERK SIGNALING

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 1 Study Section[MCT1]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

ORG_STATE: CA

PHR: PROJECT NARRATIVE Our proposed project will develop a novel teixobactin-lipopeptide hybrid antibiotic for the inhalation treatment of lung infections caused by bacterial `superbugs' which are resistant to all current antibiotics. The future outcomes of this innovative project will significantly advance medicine and directly benefit patients by developing urgently needed new treatments for otherwise untreatable bacterial lung infections.

PI_NAMEs: MALONEY, SARA ELIZABETH;RAO, GAURI G (contact);VELKOV, TONY

PROGRAM_OFFICER_NAME: XU, ZUOYU

PROJECT_TERMS: Acinetobacter baumannii;acute toxicity;Address;analog;Animal Model;Anti-Infective Agents;Antibiotic Resistance;Antibiotic Therapy;Antibiotics;antimicrobial;Antimicrobial Resistance;Bacteria;bacterial resistance;candidate selection;Cavia;Chemistry;Clinical;comparative efficacy;cost;Dangerousness;Data;design;Development;Disease Outbreaks;dosage;Drug Exposure;Drug Kinetics;Drug resistance;drug resistant bacteria;Dryness;economic value;efficacy study;Engineering;Evaluation;experience;Formulation;Future;Goals;Gram-Positive Bacteria;Grant;Healthcare;Hospitals;Human;Hybrids;Image;improved;In Vitro;in vivo;Individual;Infection;Inhalation;innovation;interdisciplinary approach;International;Klebsiella pneumoniae;Laboratories;lead candidate;Lung;Lung infections;Medical;Medicine;methicillin resistant Staphylococcus aureus;Minimum Inhibitory Concentration measurement;Modeling;Modern Medicine;non-Native;Non-Rodent Model;novel;novel antibiotic class;Outcome;parenteral administration;particle;pathogen;Patients;Pharmaceutical Chemistry;Pharmacodynamics;pharmacokinetics and pharmacodynamics;Pharmacology;Powder dose form;preclinical development;prevent;Property;Pseudomonas aeruginosa;Race;Rattus;Records;Regimen;Reporting;Resistance;Resistance development;resistant Klebsiella pneumoniae;resistant strain;Rodent Model;Site;Societies;Staphylococcus aureus;Streptococcus pneumoniae;Superbug;System;systemic toxicity;Techniques;Therapeutic;therapeutic development;Time;Toxic effect;Treatment Efficacy

PROJECT_TITLE: Development of a broad spectrum teixobactin-lipopeptide hybrid for the treatment of lung infections caused by pan-drug resistant ‘superbugs’

STUDY_SECTION: DDR

STUDY_SECTION_NAME: Drug Discovery and Mechanisms of Antimicrobial Resistance Study Section[DDR]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_CITY: HOUSTON

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: PROJECT NARRATIVE The overall goal of this proposal is to achieve a quantitative understanding of key biochemical cascades that determine the efficacy of different training protocols to induce and consolidate long-term synaptic plasticity and memory. An extension of that goal is to use knowledge of these molecular processes and their dynamics to develop novel learning protocols for enhancing synaptic plasticity and memory.

PI_NAMEs: BYRNE, JOHN H (contact)

PROGRAM_OFFICER_NAME: OSBORNE, LESLIE CAROL

PROJECT_TERMS: Affect;Aftercare;Animals;Aplysia;ATF2 gene;Back;Behavior Control;Biochemical;Biological Models;CCAAT-Enhancer-Binding Proteins;Computer Models;CREB1 gene;Cyclic AMP-Dependent Protein Kinases;Data;design;Development;efficacy evaluation;Elements;Extracellular Signal Regulated Kinases;Feedback;Goals;Hour;Human;Immunofluorescence Immunologic;improved;insight;Knowledge;Learning;long term memory;Maintenance;MAPK3 gene;Memory;Methyl-CpG-Binding Protein 2;Mitogen-Activated Protein Kinases;Modeling;Molecular;molecular dynamics;neuroregulation;novel;p38 Mitogen Activated Protein Kinase;Pattern;pharmacologic;Phosphorylation;Phosphotransferases;Physiologic pulse;Probability;Process;protein activation;Protein Kinase;protein kinase inhibitor;Protocols documentation;Ribosomal Protein S6 Kinase;ribosomal protein S6 kinase kinase;Ribosomes;RNA Interference;Role;Seminal;Serotonin;Signal Transduction;Signaling Molecule;stimulus interval;success;Synapses;Synaptic plasticity;System;Techniques;Testing;Time;Training;transcription factor;Transforming Growth Factor beta Receptors;Vertebrates;Work

PROJECT_TITLE: Analysis of the Neural Control of Behavior

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ICN-W(03)M]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human

ORG_CITY: WOODS HOLE

ORG_NAME: MARINE BIOLOGICAL LABORATORY

PHR: Narrative – Public Health Relevance The use of pluripotent stem cells for regenerative medicine holds enormous potential for understanding the root causes of diseases, as well as designing innovative strategies for treating a host of human disorders. However, this rapidly growing field is in need of highly trained scientists with expertise in stem cell biology, regeneration, and the technological methods for their applications in regenerative biology and medicine. The Frontiers in Stem Cells and Regeneration Course at the Marine Biological Laboratory in Woods Hole, MA promotes advances in the field by bringing together scientific experts and students in an advanced, hands-on training course, thus enhancing the training of the next generation of highly skilled stem cell scientists.

PI_NAMEs: HYMAN, LINDA E (contact)

PROGRAM_OFFICER_NAME: TAYMANS, SUSAN

PROJECT_TERMS: Address;adult stem cell;Aging;Animal Model;arm;Behavioral;Biological;Biology;Biomedical Research;career;Cell model;cell regeneration;cell type;Child Health;Clinical;Clinical Research;Collaborations;Complement;course introduction;design;Development;Disease;Education;Educational workshop;Environment;Ethics;experience;Fostering;frontier;fundamental research;Funding;Goals;Human;Human Development;improved;indium arsenide;innovation;Instruction;Knowledge;Laboratories;laboratory experience;laboratory experiment;Laboratory Research;lectures;Legal;marine;Mentors;Mentorship;Methods;Natural regeneration;Nervous System Disorder;next generation;novel;Participant;Physicians;pluripotency;Pluripotent Stem Cells;Population Scientist Supplement (R25);Problem Solving;Procedures;programs;public health relevance;regeneration model;regenerative biology;Regenerative Medicine;reproductive;Research;Research Personnel;research study;Research Training;Scientist;Seasons;Series;skills;skills training;stem cell biology;Stem Cell Research;stem cells;Students;success;Techniques;Technology;tissue regeneration;tool;Training;Translational Research;United States National Institutes of Health;Universities

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Reproduction, Andrology, and Gynecology Study Section[CHHD-R]


NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Clinical Research;Congenital Heart Disease;Congenital Structural Anomalies;Genetics;Heart Disease;Human Genome;Machine Learning and Artificial Intelligence;Patient Safety;Pediatric;Precision Medicine;Prevention;Rare Diseases

ORG_CITY: SALT LAKE CITY

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE This proposal will investigate the causative clinical factors, demographic variables, and genomic variants associated with bicuspid aortic valve aortopathy, a heritable condition with poorly understood pathogenesis. The proposal will use artificial intelligence methods of predictive modeling to discover clinical and demographic variables associated with BAV aortopathy as well as whole genome sequencing analysis to define the drivers of this complex disease. Successful completion of this study will allow development of precision medicine tools to predict aortic disease risk at the individual patient level. 1

PI_NAMEs: GLOTZBACH, JASON PAUL (contact)

PROGRAM_OFFICER_NAME: CHEON, YEWON

PROJECT_TERMS: Acute;Aneurysm;Aorta;Aortic Aneurysm;Aortic Diseases;aortic valve;artificial intelligence method;artificial intelligence model;Artificial Intelligence platform;Bicuspid;bicuspid aortic valve;Bioinformatics;Birth;Cardiac;Cardiovascular Diseases;Cardiovascular system;career;career development;Clinical;Clinical Medicine;clinical risk;cohort;Collaborations;comorbidity;Complex;Congenital Cardiovascular Abnormality;Data;Data Science;Demographic Factors;Dependence;Development;Diabetes Mellitus;Diagnosis;Diameter;Disease;Disease Outcome;Disease Progression;disorder risk;Dissection;Electronic Health Record;Epidemiology;experience;explainable artificial intelligence;Face;Family;Foundations;Frustration;Funding;General Population;Generations;genetic linkage analysis;genetic pedigree;Genetic Predisposition to Disease;genetic variant;Genome;genome sequencing;Genomic medicine;Genomics;Goals;Guidelines;Health system;Heritability;High Prevalence;high risk;Hospital Mortality;Hypertension;improved;improved outcome;Individual;individual patient;innovation;Investigation;K-Series Research Career Programs;Knowledge;Leadership;Logistic Regressions;Mentors;Methodology;Methods;Modeling;Morbidity - disease rate;mortality;multidisciplinary;novel;Operative Surgical Procedures;Outcome;Pathogenesis;Patient Care;Patient risk;Patients;pediatric cardiologist;Persons;Phenotype;Population;population based;Population Database;Population Study;Positioning Attribute;precision medicine;predictive modeling;Prevalence;prevent;Prevention;Preventive treatment;Principal Investigator;Procedures;professor;programs;prospective;Regression Analysis;Research;Research Personnel;Risk;risk prediction model;risk stratification;Science;Scientist;sex;skills;Statistical Methods;statistics;Surgeon;surgical risk;tenure track;Testing;Thoracic aorta;tool;Training;Translational Research;translational scientist;Universities;Unnecessary Surgery;Utah;Variant;whole genome

PROJECT_TITLE: Towards Precision Medicine for Thoracic Aortic Disease: Defining the Clinical and Genomic Drivers of Bicuspid Aortopathy

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(JA)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Congenital Structural Anomalies;Intellectual and Developmental Disabilities (IDD);Mental Health;Mental Illness;Neurosciences;Pediatric;Primary Immunodeficiencies;Rare Diseases;Schizophrenia

PHR: PROJECT NARRATIVE Extensive evidence in humans and animal models suggest that reduced long-range connectivity and disconnection between brain areas are signatures of schizophrenia. However little is about how such reduced connectivity affects specific circuit components and cortical function. The overall goal of this project is to determine how altered bottom-up and top-down connectivity in schizophrenia impacts sensory processing, and unveil the role of neurogliaform cells, a GABAergic cell type highly affected in schizophrenia, in bottom-up and top-down sensory processing in health and in the context of schizophrenia. Ultimately, such knowledge has the potential to offer new opportunities for identification of biomarkers of disease and for therapeutic interventions that target specific circuits.

PI_NAMEs: BATISTA-BRITO, RENATA  (contact)

PROGRAM_OFFICER_NAME: ROSSI, ANDREW F

PROJECT_TERMS: 22q11.2;Affect;Anatomy;Animal Model;Anterior;Apical;Area;area striata;Autopsy;Axon;Behavior;Biological Markers;Biological Models;biomarker identification;Brain;Calcium;cell type;Cells;cingulate cortex;Cognitive deficits;cognitive function;Data;Dendrites;density;DiGeorge Syndrome;Dimensions;Disease;Electrophysiology (science);Environment;extracellular;frontal lobe;Functional disorder;Functional Imaging;Goals;Health;Human;human model;Image;imaging study;Impaired cognition;Impairment;in vivo;inhibitory neuron;innovation;Interneurons;Knowledge;Measurable;Measures;Mediating;Modeling;mouse model;Mus;neural circuit;Neurodevelopmental Disorder;Neurons;neuropsychiatric disorder;neuroregulation;novel strategies;optogenetics;Patients;Phenocopy;Play;Population;Prefrontal Cortex;Process;Pyramidal Cells;Reporting;Research;response;Role;Schizophrenia;Sensory;sensory stimulus;Stimulus;structural imaging;Testing;Thalamic Nuclei;Thalamic structure;Therapeutic Intervention;Time;tool;transcriptomics;two-photon;Visual;visual stimulus;Visual System;Wild Type Mouse;Work

PROJECT_TITLE: Investigating abnormalities in top-down cortical processing and behavior in a model of the 22q11.2 deletion

STUDY_SECTION: PMDA

STUDY_SECTION_NAME: Pathophysiological Basis of Mental Disorders and Addictions Study Section[PMDA]


NIH_SPENDING_CATS: Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Prevention;Sleep Research

ORG_CITY: BINGHAMTON

ORG_NAME: STATE UNIVERSITY OF NY,BINGHAMTON

PHR: Project Narrative  Cardiometabolic (CM) diseases including cardiovascular (CV) and metabolic diseases are interconnected and positively associated with multi-domain Cardiometabolic Risk Factors (CMRFs) such as metabolic dysregulation, obesity, physical inactivity, poor nutrition, and other emerging factors (including and especially sleep disorders). CMRFs are highly and increasingly prevalent in the young population that foreshadows a future epidemic of incident CM diseases as they age, but existing studies on CM health have primarily focused on the adult and senior population with little to no knowledge on adolescents and young adults. We propose a multi-study cross-dataset secondary analysis for CM subgroup discovery and risk prediction in adolescents (11-18) and young adults (19-39) using two combined datasets from NHANES and NSRR, providing evidence-based guidelines to facilitate early and targeted interventions and help establish health promoting behaviors in adolescents and young adults, and eventually improving CM health care in their transition to adulthood and reducing CM health disparities and costs in the U.S. as the young population ages.

PI_NAMEs: SI, BING  (contact)

PROGRAM_OFFICER_NAME: ALFINI, ALFONSO JOSEPH

PROJECT_TERMS: Address;Adolescent;Adolescent and Young Adult;Adult;African American population;Age;Algorithms;American;Asian Americans;Behavior;blood-based biomarker;Cardiometabolic Disease;cardiometabolic risk;cardiometabolism;Cardiovascular Diseases;Cardiovascular system;caucasian American;Clinical;Collection;cost;Data;Data Pooling;Data Set;Diabetes Mellitus;Dimensions;Early treatment;Evaluation;evidence based guidelines;future epidemic;Health;Health Care Costs;health disparity;Health Promotion;Healthcare;Heterogeneity;Hispanic Populations;improved;Individual;insight;interest;Intervention;Knowledge;Latino Population;lifestyle intervention;Measures;Metabolic;Metabolic Diseases;Modeling;Morbidity - disease rate;mortality;multilevel analysis;National Health and Nutrition Examination Survey;novel;nutrition;Obesity;Outcome;outcome prediction;Patient risk;Patient Self-Report;Patients;physical inactivity;Population;preventable death;Prognosis;Prognostic Factor;Research;research clinical testing;Risk;Risk Factors;risk prediction;risk stratification;secondary analysis;Sleep;Sleep Deprivation;Sleep Disorders;sleep health;Subgroup;transfer learning;transition to adulthood;United States;young adult

PROJECT_TITLE: Sleep and Cardiometabolic Subgroup Discovery and Risk Prediction in United States Adolescents and Young Adults: A Multi-Study Multi-Domain Analysis of NHANES and NSRR

STUDY_SECTION: CDMA

STUDY_SECTION_NAME: Clinical Data Management and Analysis Study Section[CDMA]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Chronic Liver Disease and Cirrhosis;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Liver Disease;Nutrition;Obesity;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: Project Narrative Persons of Mexican and Central American heritage have the highest rates of nonalcoholic fatty liver disease (NAFLD), leading to rising morbidity from cirrhosis and hepatocellular carcinoma. Behavioral weight loss interventions may improve NAFLD outcomes, but little is known about how to do so effectively among this population. The proposed research will provide important insights into behavioral strategies and interventions to reduce the burden of this public health problem and health disparity.

PI_NAMEs: BALAKRISHNAN, MAYA  (contact)

PROGRAM_OFFICER_NAME: MARTIN, IMAN

PROJECT_TERMS: Acceleration;acceptability and feasibility;Acculturation;Address;Age;Area;Behavior;behavior change;behavior test;Behavior Therapy;Behavioral;Biological Markers;Black Populations;Body Weight decreased;burden of illness;career development;Central American;chronic liver disease;Cirrhosis;Clinical;Cognitive;cohort;college;Complex;County;Coupled;Cultural Sensitivity;Data;design;diabetic;Diet;Disease Outcome;Disparity;Documentation;effective therapy;Environment;Epidemiology;ethnic minority population;Evolution;experience;Fatty acid glycerol esters;Feedback;Fibrosis;Focus Groups;Foundations;Funding;Goals;Health;Health behavior change;health disparity;Hepatology;Hispanic;Hispanic Populations;improved;improved outcome;Infrastructure;Injury;insight;Institution;Intervention;intervention effect;intervention participants;Interview;K-Series Research Career Programs;lifestyle intervention;Liver;Liver diseases;Liver Fibrosis;liver injury;Medicine;Mentors;Mentorship;Mexican;Mexican Americans;minority communities;Modeling;Modification;Morbidity - disease rate;multidisciplinary;National Institute on Minority Health and Health Disparities;non-alcoholic fatty liver disease;Not Hispanic or Latino;Obesity;Outcome;Participant;participant enrollment;patient oriented;patient population;Patients;Perception;Persons;Physical activity;Population;Positioning Attribute;Primary carcinoma of the liver cells;Primary Prevention;Process;Public Health;Qualitative Methods;Research;Research Personnel;Sampling;Scientist;Secondary Prevention;Series;sex;social;social cognitive theory;social factors;social influence;social structure;sociodemographics;Source;stem;structural determinants;Structure;Subgroup;systematic review;Target Populations;Testing;Time;Training;Training Activity;treatment arm;treatment as usual;trial design;United States National Institutes of Health;Weight;weight loss intervention

PROJECT_TITLE: Improving Outcomes Among Mexican and Central-American Patients with Nonalcoholic Fatty Liver Disease


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Breastfeeding, Lactation and Breast Milk;Childhood Obesity;Clinical Research;Eating Disorders;Mental Health;Neurosciences;Nutrition;Obesity;Pediatric;Prevention;Women's Health Research

ORG_CITY: LOS ANGELES

ORG_NAME: CHILDREN'S HOSPITAL OF LOS ANGELES

PHR: Project Narrative Identification of specific HMO’s in breastmilk that may be protective for obesity and brain development can be used to inform design of more effective supplements that could be used to boost availability for breastfed infants or added to infant formula. Identified HMOs could also be explored for potential utility in the broader population beyond infants. Findings from this cohort will also be important in terms of the design of healthier formulas to optimize growth and development

PI_NAMEs: GORAN, MICHAEL ISAAC (contact);PETERSON, BRADLEY S

PROGRAM_OFFICER_NAME: MARUVADA, PADMA

PROJECT_TERMS: Abdomen;Affect;Age;Age Months;Anatomy;Anisotropy;Appetite Regulation;Area;arterial spin labeling;Basal Ganglia;Birth;Blood flow;Body fat;Body measure procedure;Brain;Brain imaging;brain magnetic resonance imaging;Brain region;Breast;Breast Feeding;Breastfed infant;Carbohydrates;Cognitive;cognitive development;cognitive enhancement;cognitive function;cognitive performance;cognitive testing;cohort;Complex;Data;design;Development;dietary;Diffusion Magnetic Resonance Imaging;Dual-Energy X-Ray Absorptiometry;early childhood;Early identification;Eating;Eating Behavior;eating in absence of hunger;Ethics;Exposure to;Fatty acid glycerol esters;feeding;follow-up;frontal lobe;Fucose;Functional Magnetic Resonance Imaging;gray matter;Growth;Growth and Development function;gut microbiome;Hippocampus;Hispanic;Human Milk;human milk oligosaccharides;Hypothalamic structure;Image;immune function;improved;Infant;infant adiposity;Infant Food;Infant formula;infant nutrition;infant outcome;Knowledge;Laboratories;Language;Life;Link;Liver;Logistics;Magnetic Resonance;Magnetic Resonance Imaging;Measures;Mediating;Metabolic;Methods;Mothers;Motor;multimodality;myelination;Neurons;novel;Obesity;Outcome;Perfusion;Play;Population;prebiotics;Questionnaires;Radiation;reduced food intake;Rest;Role;Sampling;Series;Sialic Acids;Source;Structure;subcutaneous;Thinness;Time;Tissues;Toddler;United States National Institutes of Health;Visceral;Weight Gain;white matter;Work

PROJECT_TITLE: "Impact of Early feeding and human milk oligosaccharides on obesity and brain development".

STUDY_SECTION: HSDO

STUDY_SECTION_NAME: Human Studies of Diabetes and Obesity Study Section[HSDO]


NIH_SPENDING_CATS: Cancer;Urologic Diseases

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Project Narrative Tumor cell motility is a complex but carefully coordinated process that contributes to disease progression by enabling tumor cells to disseminate away from the primary tumor (metastasize). Extracellular vesicles (EV) have recently been identified as important contributors to tumor cell motility and cancer metastasis, however, it remains unknown how cancer can control the production of such vesicles and how this is coordinated with other mechanisms of cell motility. We will investigate how integration of cell-cell adhesion with vesicle biogenesis ultimately controls EV production and aim to show how this coordination controls tumor cell motility and metastasis.

PI_NAMEs: PUA, HEATHER H (contact);WEAVER, ALISSA M

PROGRAM_OFFICER_NAME: WOODHOUSE, ELIZABETH

PROJECT_TERMS: Activated-Leukocyte Cell Adhesion Molecule;adhesion receptor;Adhesions;Autocrine Communication;Back;Behavior;Biogenesis;Biological;Biological Process;Biology;Bladder Carcinoma;Bladder Urothelium;Cadherins;cancer cell;Cancer cell line;Cancer Patient;Cell Adhesion;Cell Line;cell motility;Cell-Cell Adhesion;Cells;Cessation of life;Chemicals;Clinical;clinical phenotype;clinically significant;Coculture Techniques;Companions;Complex;Cytoplasm;Disease Progression;DNA;Equilibrium;Event;Exhibits;experimental study;extracellular vesicles;Human;imaging probe;Immunoglobulin G;innovation;Integrins;Intervention;Invaded;Knockout Mice;Laboratories;Laboratory Study;Length;Letters;Link;Lipids;Malignant - descriptor;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Mass Spectrum Analysis;Mediating;Mediator;Melanoma differentiation associated gene-9;member;Modeling;Molecular;Motility;mouse model;Neoplasm Metastasis;neoplastic cell;novel;Papilloma;paracrine;Paracrine Communication;Pathway interactions;Phenotype;Primary Neoplasm;Process;Production;prognostic indicator;Protein Isoforms;Proteins;Proteomics;Publishing;Regulation;Reproducibility;Resistance;response;Retrospective cohort;RNA;RNA Splicing;Scaffolding Protein;Structure;success;survival prediction;synergism;System;Testing;tumor;tumor progression;Tumor-Derived;Urine;Validation;Variant;Vesicle;vesicular release;Work

PROJECT_TITLE: Regulation of extracellular vesicle biogenesis through cell adhesion

STUDY_SECTION: ICI

STUDY_SECTION_NAME: Intercellular Interactions Study Section[ICI]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Bioengineering

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: This project is focused on characterizing how stabilizing the active sites of protein kinases in specific conformations affect their biochemical and cellular properties. Kinases are highly pursued therapeutic targets for a number of diseases including cancer and chronic inflammation. Exploring how specific active site conformations affect the signaling properties of protein kinases will inform the development of new therapeutics for cancer and inflammation.

PI_NAMEs: MALY, DUSTIN J (contact)

PROGRAM_OFFICER_NAME: BARSKI, OLEG

PROJECT_TERMS: Active Sites;Affect;Architecture;Binding;Binding Sites;Biochemical;Biochemistry;Biological;cell motility;Cells;Cellular biology;chemical genetics;Chemicals;chemoproteomics;chimeric antigen receptor T cells;Chronic;Clinical;Complement;Data Set;Development;Disease;engineered T cells;Enzymatic Biochemistry;Funding;Generations;Goals;Inflammation;inhibitor;interest;intermolecular interaction;Invaded;kinase inhibitor;Logic;Lymphocyte-Specific p56LCK Tyrosine Protein Kinase;Malignant Neoplasms;Membrane;Methodology;Methods;Molecular;Molecular Analysis;Molecular Conformation;Molecular Probes;mutant;N-terminal;new technology;novel therapeutics;Output;Pharmaceutical Preparations;Phosphorylation;Phosphotransferases;Play;Property;protein function;Protein Kinase;Protein Tyrosine Kinase;Proteolysis;Receptor Signaling;recruit;Regulation;Role;scaffold;Series;Signal Transduction;Site;src-Family Kinases;Surface;System;T-Cell Receptor;Tail;therapeutic target;tool;tool development;Variant;Yeasts

PROJECT_TITLE: New Molecular Probes For Protein Kinases

STUDY_SECTION: SBCA

STUDY_SECTION_NAME: Synthetic and Biological Chemistry A Study Section[SBCA]


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Neurosciences

ORG_DEPT: PSYCHOLOGY

ORG_NAME: COLUMBIA UNIV NEW YORK MORNINGSIDE

PHR: PROJECT NARRATIVE In a complex, yet structured world, abstraction is a process that identifies the common features across past experiences in such a way that both allows for a more compact representation and can be generalized to new experiences so as guide behavioral and emotional responses. Here we develop a theoretical framework and analytic toolkit for studying how the human brain learns, represents, and utilizes abstract knowledge in a format that supports generalization, and how this process of abstraction interfaces with motivational states. Our work promises to elucidate the mechanisms of abstract learning in the human brain and lays the foundation for studying how abstraction and generalization go awry in psychiatric disease.

PI_NAMEs: SALZMAN, C. DANIEL;SHOHAMY, DAPHNA  (contact)

PROGRAM_OFFICER_NAME: RANGEL GOMEZ, MAURICIO

PROJECT_TERMS: Address;Affective;Amygdaloid structure;Area;Behavior;behavior prediction;Behavioral;Behavioral Mechanisms;Brain;Brain region;Categories;Cognitive;cognitive function;cognitive neuroscience;Complex;Corpus striatum structure;Cues;Data;Decision Making;Desire for food;Dimensions;Disease;Dorsal;emotion regulation;Emotional;emotional functioning;entorhinal cortex;Environment;Evolution;experience;experimental study;flexibility;Foundations;Functional Magnetic Resonance Imaging;Geometry;Grouping;Health;Hippocampus;Hour;Human;human subject;Impairment;Individual Differences;individual variation;insight;Knowledge;Learning;Link;Maps;Measures;medial temporal lobe;memory consolidation;Mental disorders;Methodology;Motivation;Motor Cortex;neural;neural patterning;neuromechanism;nonhuman primate;novel;Outcome;Output;Performance;performance tests;Population;Prefrontal Cortex;Process;Psychopathology;response;Response to stimulus physiology;Reversal Learning;Rewards;Role;statistics;Stimulus;Structure;System;Testing;Training;transfer learning;Visual Cortex;Work

PROJECT_TITLE: The geometry of neural representations reflecting abstraction in humans

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BP-N(02)M]


NIH_SPENDING_CATS: Assistive Technology;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Mental Health;Mental Illness;Neurosciences;Prevention;Serious Mental Illness;Suicide;Suicide Prevention

PHR: PROJECT NARRATIVE Suicide is a leading cause of death worldwide, with tragic consequences for individuals and their families. Despite major resources invested over the last decades to find strategies to reduce the incidence of suicides and suicide attempts, rates of attempted and completed suicide have increased in the last 20 years. The proposed research seeks to address the need for rapid, safe and effective treatments to prevent suicide in the most vulnerable periods (i.e. psychiatric hospitalization and post-discharge weeks) by studying individualized MRI-guided accelerated transcranial magnetic stimulation (TMS) to a novel parietal brain target and assessing both target engagement (to a new suicide biomarker) and clinical efficacy.

PI_NAMEs: CAMPRODON, JOAN A (contact)

PROGRAM_OFFICER_NAME: ANKUDOWICH, ELIZABETH

PROJECT_TERMS: Acceleration;Acute;Address;Anterior;anti-depressive agents;Area;behavior measurement;Biological;Biological Markers;Brain;Cause of Death;Cellular Phone;cingulate cortex;Clinical;clinical efficacy;completed suicide;confirmatory trial;depressive symptoms;Development;Devices;Digital biomarker;effective therapy;electric field;executive function;Family;Feeling suicidal;Functional disorder;Future;Hospitalization;Incidence;Individual;Inferior;innovation;inpatient psychiatric treatment;Investments;Lobule;Magnetic Resonance Imaging;Measures;Mental Depression;Mental Health Services;Modeling;neuroregulation;novel;novel marker;Parietal;Patients;Phase;Physiologic pulse;Positioning Attribute;predictive marker;Prefrontal Cortex;Protocols documentation;Psychiatric therapeutic procedure;Psychiatry;Randomized;reducing suicide;Research;Resources;response;response biomarker;Safety;suicidal;suicidal behavior;suicidal patient;Suicide;Suicide attempt;Suicide prevention;suicide rate;Therapeutic;Transcranial magnetic stimulation;Treatment Efficacy;treatment strategy;wearable device

PROJECT_TITLE: Suicide Circuit Therapeutics: Engaging Novel Targets with Rapid and Individualized MRI-Guided Accelerated TMS


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics;Macular Degeneration;Neurodegenerative;Neurosciences

ORG_CITY: STORRS-MANSFIELD

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF CONNECTICUT STORRS

PHR: PROJECT NARRATIVE G. Zarkada Abnormal formation of new blood vessels is the fundamental cause of catastrophic vision loss during ocular neovascularization, stressing the urgent need for development of new treatments. We have identified components of the transforming growth factor-β (TGFβ) signaling pathway that strongly affect retinal angiogenesis, both in pro- and anti-angiogenic ways. We propose to selectively manipulate TGFβ signaling components in endothelial cells, in order to treat retinopathy in preclinical models of retinal vascular disease.

PI_NAMEs: ZARKADA, GEORGIA  (contact)

PROGRAM_OFFICER_NAME: GORDIYENKO, NATALIYA

PROJECT_TERMS: Ablation;Affect;Age related macular degeneration;angiogenesis;Angiogenesis Inhibitors;antagonist;arm;Award;Biology;Blindness;Blood Vessels;Cardiovascular system;cell behavior;Cell Maturation;Cell Proliferation;Cell Separation;Cellular biology;Choroidal Neovascularization;comparative;conditional knockout;Data;Defect;Development;Diabetic Retinopathy;Disease;Endothelial Cells;Endothelium;experimental study;Eye;Eye diseases;Future;Gene Expression;Gene Targeting;Genetic;genetic approach;Genetic Transcription;Goals;In Vitro;in vivo;Individual;insight;Intervention;Knockout Mice;Laboratories;Learning;lectures;Literature;loss of function;MADH2 gene;MADH3 gene;Mediating;medical schools;Medicine;Mentors;Mentorship;Messenger RNA;Methodology;Mission;Modeling;Molecular;Molecular Target;mouse model;Mus;mutant;National Eye Institute;neovascular;neovascularization;Neuropilin-1;new therapeutic target;next generation;novel;ocular neovascularization;Pathologic;Patients;Pattern;pharmacologic;Pharmacological Treatment;Phase;Phosphorylation;Physiological;Positioning Attribute;postnatal;Pre-Clinical Model;preservation;Principal Investigator;programs;Protocols documentation;Publishing;Receptor Activation;Regulation;Reporting;Research Personnel;Research Proposals;response;Retina;retinal angiogenesis;Retinal Diseases;Retinal Neovascularization;Rodent Model;Role;Series;side effect;Signal Pathway;Signal Transduction;Solid;Stress;Testing;TGFB1 gene;Therapeutic;Therapeutic Intervention;therapy outcome;Time;Training;Training Programs;transcription factor;transcriptome sequencing;transcriptomic profiling;Transforming Growth Factor beta;Transforming Growth Factor beta Receptors;translational model;Vascular Diseases;vascular factor;VEGFA gene;Vision;Work

PROJECT_TITLE: Targeting TGFB signaling to treat ocular neovascular disease

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurosciences;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse;Substance Misuse Prevention;Underage Drinking

ORG_CITY: Columbus

ORG_DEPT: PSYCHIATRY

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative The proposed project will investigate the intersection of socio-cultural determinants of alcohol use and related problems in youth, focusing on Hispanic/Latina/x/o youth, to identify factors of risk and resiliency. Given that health disparities emerge in childhood and can result from systemic inequities, this project will investigate how youth alcohol use and mental health intersect to exacerbate or buffer subsequent influences on neurocognitive and school performance in youth.

PI_NAMEs: GONZALEZ, MARYBEL ROBLEDO (contact)

PROGRAM_OFFICER_NAME: RUFFIN, BEVERLY

PROJECT_TERMS: Accidents;Adolescence;Adolescent;adolescent substance use;Adult;Affect;Age;Alcohol abuse;Alcohol consumption;alcohol related problem;alcohol risk;alcohol use disorder;Alcohols;Anxiety;Area;Brain;Buffers;Cause of Death;Childhood;Cognition;Cognitive;cognitive development;cognitive function;Communities;community engaged approach;community engaged research;community engagement;conduct problem;Country;cultural values;Data;Data Set;depressive symptoms;deter alcohol use;Development;Discrimination;Disparity;emotional functioning;Environment;Equation;ethnic identity;Ethnic Origin;experience;Exposure to;Factor Analysis;Family;Feedback;Focus Groups;Future;Gender;Health;health determinants;health disparity;Heavy Drinking;high risk;Hispanic;Homicide;Individual;Inequity;Intervention;Knowledge;Latina;Latino;Latino Population;Latinx;Link;longitudinal design;Longitudinal Studies;Mental Depression;Mental Health;Methods;Modeling;Neighborhoods;Neurobiology;Neurocognitive;novel;Outcome;Parents;Pathway interactions;peer;Performance;Policies;Prevention;Prevention Research;Problem behavior;Process;Psyche structure;psychosocial;Race;recruit;Reduce health disparities;Research;Research Methodology;resilience;Resources;response;Risk;Risk Factors;Role;Sampling Studies;Schools;Shapes;Site;Social Change;social culture;social determinants;social health determinants;Social Identification;sociocultural determinant;Specificity;Structure;Suicide;Testing;Time;Training;Translations;underage drinking;young adult;Youth

PROJECT_TITLE: Socio-cultural and community risk and resilience for alcohol related problems in youth

STUDY_SECTION: AA

STUDY_SECTION_NAME: Epidemiology, Prevention and Behavior Research Study Section[AA-2]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Genetics;Infectious Diseases

ORG_CITY: CLEVELAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

PHR: PROJECT NARRATIVE Gastrointestinal disorders caused by pathogenic bacteria represent a serious health problem worldwide by causing high mortality in infant, immunocompromised and elderly people and contributing to chronic inflammatory conditions, such as inflammatory bowel diseases. This project will improve understanding the pathogenesis of gastrointestinal bacterial infections by exploring novel mechanisms that regulate pathogen interactions with intestinal epithelium and bacterial invasion into host cells. Furthermore, it will identify novel targets for pharmacological prevention of intestinal colonization by pathogenic bacteria, which would decrease morbidity and mortality of a large cohort of patients with enteric infections.

PI_NAMEs: IVANOV, ANDREI IVANOVICH (contact)

PROGRAM_OFFICER_NAME: LUNSFORD, DWAYNE

PROJECT_TERMS: Acceleration;Actins;Adherent Invasive Escherichia coli;Antibiotic Therapy;Attenuated;Automobile Driving;Bacteria;Bacterial Adhesion;Bacterial Antibiotic Resistance;Bacterial Attachment Site;Bacterial Infections;blebbistatin;Cell Communication;Cell Line;Cell surface;Cells;Chemicals;Chronic;Citrobacter rodentium;cohort;CRISPR/Cas technology;crosslink;Cytoskeleton;Data;Disease;Economic Burden;Elderly;Enteral;enteric infection;enteric pathogen;enteropathogenic Escherichia coli;Epithelial Cells;Epithelium;Escherichia coli;Escherichia coli EHEC;Event;Filament;Gastroenteritis;gastrointestinal;Gastrointestinal Diseases;Genes;Genetic;genetic approach;genetic manipulation;gut colonization;Health;Hemolytic-Uremic Syndrome;Human;Immunocompromised Host;improved;In Vitro;in vivo;Infant Mortality;Infection;Inflammatory;Inflammatory Bowel Diseases;inhibitor;innovation;insight;Intestinal Diseases;intestinal epithelium;Intestinal Mucosa;Invaded;Knock-out;Knockout Mice;Mediating;Microfilaments;Modeling;Molecular;Molecular Chaperones;monolayer;Morbidity - disease rate;mortality;Motor;Motor Activity;Mus;mutant;Myosin ATPase;Myosin Type II;new therapeutic target;non-muscle myosin;novel;novel therapeutic intervention;novel therapeutics;Organoids;Outcome;pathogen;Pathogenesis;pathogenic bacteria;Pathogenicity;Pathway interactions;Patients;Persons;pharmacologic;Play;polymerization;Polymers;Prevention;Process;Protein Isoforms;Proteins;Public Health;receptor;Regulation;RNA Interference;Role;Route;Salmonella;Salmonella enterica;Severities;Shigella;Symptoms;Systemic disease;Testing;Therapeutic Intervention;Transgenic Mice

PROJECT_TITLE: Novel cytoskeletal mechanisms of pathogenic bacteria interactions with intestinal epithelium

STUDY_SECTION: DHMI

STUDY_SECTION_NAME: Digestive System Host Defense, Microbial Interactions and Immune and Inflammatory Disease Study Section[DHMI]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Liver Disease;Substance Misuse

ORG_CITY: NEW ORLEANS

ORG_DEPT: PATHOLOGY

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: Project Narrative: Liver cirrhosis is one of the leading causes of death worldwide, and alcoholic liver disease (ALD) accounts for half of cirrhosis-associated death. Alcohol-induced DNA damage and the consequent hepatocyte cell death have been shown to participate in ALD progression. Clarifying the involvement of ALD-induced aspartate beta- hydroxylase down-regulation in exacerbating hepatocyte DNA damage and cell death may identify the potential therapeutic approach for ALD patients.

PI_NAMEs: HUANG, CHIUNG-KUEI  (contact)

PROGRAM_OFFICER_NAME: PERRUCCIO, ELIZABETH M

PROJECT_TERMS: advanced disease;Affect;Alcohol abuse;Alcoholic Hepatitis;Alcoholic Liver Diseases;Alcoholic steatohepatitis;Alcohols;Animal Experiments;Animal Feed;Aspartate;Cause of Death;Cell Death;Cell Death Induction;cell injury;Cessation of life;Chronic;chronic alcohol ingestion;chronic liver disease;Cirrhosis;comparison control;CRISPR/Cas technology;Data;Development;dietary control;disease model;Disease Progression;DNA;DNA Damage;Down-Regulation;Ectopic Expression;effective therapy;Ethanol;feeding;Gamma-H2AX;Goals;Hepatic;Hepatocyte;Homeostasis;Human;in vivo;innovation;insight;knock-down;Knock-out;Knowledge;Laboratories;Link;Liver;Liver Cirrhosis;Liver Fibrosis;liver injury;Maintenance;Malignant neoplasm of liver;Mediating;Mediator;Microinjections;Mixed Function Oxygenases;Molecular;Mus;novel;overexpression;Patients;Phosphorylation;Pilot Projects;Plasmids;problem drinker;protective effect;Proteomics;Regulation;Research;response;Rodent;Role;Severity of illness;System;Testing;Therapeutic;therapeutic target;Toxin;Transgenic Mice;Up-Regulation;Viral

PROJECT_TITLE: Aspartate beta-hydroxylase and DNA damage in chronic liver diseases

STUDY_SECTION_NAME: Biomedical Research Study Section[AA-1]


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;HIV/AIDS;Health Services;Heart Disease;Infectious Diseases;Prevention

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE The Kingdom of eSwatini has the world’s highest prevalence of HIV, but has become a world leader in HIV treatment and achieved dramatic declines in HIV mortality. In contrast, deaths from many non-communicable diseases (NCDs) in eSwatini are increasing, including the second-leading cause of death after HIV: cardiovascular disease. This project will examine the potential efficiency of HIV/NCD care integration over the future course of the HIV epidemic, identify optimal health benefits packages produce the greatest health benefits across major communicable and non-communicable diseases, and consider potential adjustments to health benefits due to the risk of future health systems disruptions such as pandemics, conflict, and natural disasters.

PI_NAMEs: BERSHTEYN, ANNA  (contact);REVILL, PAUL

PROGRAM_OFFICER_NAME: VITALIS, DEBBIE

PROJECT_TERMS: 1 year old;Acquired Immunodeficiency Syndrome;Active Learning;Address;Adult;Africa South of the Sahara;African;Age;aging related;antiretroviral therapy;Binding;Budgets;Cardiovascular Diseases;cardiovascular disorder prevention;care delivery;care systems;Caring;Cause of Death;Central Africa;Cessation of life;Chronic;Chronic Care;Chronic Kidney Failure;climate change;Community Health;Conflict (Psychology);cost;Country;demographics;design;Diabetes Mellitus;Diagnosis;Disease;Eastern Africa;Enrollment;Epidemic;epidemiological model;Equilibrium;Event;Face;falls;Frequencies;Future;General Population;Generations;Goals;Health;Health Benefit;health care delivery;health data;health economics;Health Personnel;Health Policy;Health Resources;Health Services;Health system;Healthcare Systems;High Prevalence;HIV;HIV-1;HIV/AIDS;Hour;Human Resources;implementation science;improved;Incidence;Individual;interest;Interruption;Investments;Life Expectancy;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Mental disorders;Modeling;Morbidity - disease rate;mortality;Natural Disasters;Onset of illness;pandemic disease;pandemic potential;Persons;Policies;Policy Making;Population Growth;population health;prevent;Prevention;Preventive care;Preventive Health Services;Primary Prevention;promote resilience;prospective;Reading;Recommendation;Relaxation;Relaxation Therapy;Research;resilience;Resource Allocation;Resources;Risk;Self-Injurious Behavior;Services;Severities;sex;Shock;Southern Africa;supercomputer;Time;Training;Violence;Viral Load result;Work;World Health Organization

PROJECT_TITLE: Leveraging HIV care systems to improve cardiovascular disease prevention in the Kingdom of eSwatini

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Neurodegenerative;Neurosciences;Peripheral Neuropathy;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Transplantation

ORG_CITY: AUSTIN

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

PHR: PROJECT NARRATIVE  Segmental-loss peripheral nerve injuries are currently rather in-effectively treated with cadaveric nerve allografts, stimulating slow regeneration of outgrowing axons with various drugs or other substances. Our proposal seeks to investigate and develop potentially synergistic methods of axon fusion and localized immunosuppression of peripheral nerve allografts to circumvent these problems and lead to a new standard of treatment for segmental-loss peripheral nerve defects.

PI_NAMEs: BITTNER, GEORGE DAVIS (contact);BUSHMAN, JARED SHANE

PROGRAM_OFFICER_NAME: KUMSA, DOE WONDWOSSEN

PROJECT_TERMS: 3-Dimensional;Ablation;Acceleration;acronyms;Allogenic;Allografting;Animal Model;Applied Research;Autologous Transplantation;Axon;axon regeneration;Behavior;Behavioral;Biological Models;Biological Products;Biomedical Engineering;Cadaver;Cells;Clinical;clinical practice;clinical translation;clinically significant;Collaborations;cost;Cytoplasm;Defect;design;Development;Devices;Distal;Doctor of Philosophy;Esthesia;experience;Family suidae;Functional disorder;functional improvement;Funding Opportunities;Goals;Graft Rejection;Health;Human;human tissue;Hydrogels;Immune response;Immunologist;Immunosuppression;implantation;improved;improved outcome;Injury;International;Legal patent;Licensing;Malignant Neoplasms;median nerve;Methods;Microsurgery;Mission;motor behavior;Myelin;Natural regeneration;Nerve;nerve gap;Nerve Regeneration;Nervous System;novel;Operative Surgical Procedures;Organ Transplantation;Orthopedics;Outcome;pathogen;Patient-Focused Outcomes;Peer Review;Peripheral nerve injury;Peripheral Nerves;Pharmaceutical Preparations;Polyethylene Glycols;Polyethylenes;porcine model;prevent;Process;programs;Publishing;Rattus;Recovery;Regenerative Medicine;Regulatory T-Lymphocyte;reinnervation;repaired;Risk;sciatic nerve;Series;standard care;standard of care;success;supportive environment;Surgeon;Surgical sutures;Techniques;Technology;technology development;Therapeutic;Therapeutic immunosuppression;Time;Tissue Procurements;Tissues;Translating;Translations;Trauma;United States National Institutes of Health;Universities;Wallerian Degeneration

PROJECT_TITLE: Translating Novel Peripheral Nerve Allograft Technologies Toward Clinical Use

STUDY_SECTION: BNVT

STUDY_SECTION_NAME: Bioengineering of Neuroscience, Vision and Low Vision Technologies Study Section[BNVT]


NIH_SPENDING_CATS: Behavioral and Social Science;Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Immunization;Lung;Lung Cancer;Prevention;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: SYKESVILLE

ORG_NAME: ANTIDOTE THERAPEUTICS, INC.

PHR: Cigarette smoking is the leading cause of death and morbidity from any addictive drug, responsible for 400,000 deaths per year in the US, and direct healthcare costs exceeding $170 billion/yr. Only ~20% of smokers achieve long-term abstinence using standard of care pharmacotherapies and there have been no FDA authorized anti-smoking treatments with a novel mechanism of action (MOA) since 2006. Following a recent pre- IND meeting with the FDA for ATI-1013 (an anti-nicotine human monoclonal antibody with a novel MOA that has achieved pre-clinical proof-of-concept), this project is focused on completing the remaining preclinical drug development and regulatory work in accordance with the specific FDA recommendations received to obtain an approved IND and begin clinical testing.

PI_NAMEs: KALNIK, MATTHEW W (contact)

PROGRAM_OFFICER_NAME: MACDONALD, MARY THERESA

PROJECT_TERMS: Acute;addiction;Advanced Development;American;Anesthesiology;Antibodies;Antismoking;assay development;Authorization documentation;Award;Binding;Biological Assay;blood pressure elevation;Brain;Cardiovascular Diseases;Cause of Death;cell bank;Cell Culture Techniques;Cell Line;Cessation of life;cigarette smoking;Clinical;clinical development;Clinical Trials;Collaborations;Companions;Contracts;cross reactivity;Cyclic GMP;cytokine;Development;Development Plans;Disease;Disease Progression;Documentation;Dose;drug quality;experience;FDA approved;first-in-human;Formulation;Future;Goals;Half-Life;Health Care Costs;Human;human monoclonal antibodies;human study;improved;in vivo;Individual;Industry;Infusion procedures;innovation;Investigational New Drug Application;Legal patent;long term abstinence;Lung;Malignant neoplasm of lung;Malignant Neoplasms;Mammalian Cell;manufacture;manufacturing organization;manufacturing process;Marketing;Medical;medication compliance;Medicine;meetings;Monoclonal Antibodies;Morbidity - disease rate;National Cancer Institute;new product development;Nicotine;Nicotine Dependence;nicotine exposure;nicotine replacement;nicotine self-administration;nicotine treatment;Nicotinic Receptors;No-Observed-Adverse-Effect Level;non-smoker;novel;novel strategies;Orphan Drugs;Pain;Patients;Peripheral;Peripheral Blood Mononuclear Cell;Pharmaceutical Preparations;Pharmacology;Pharmacology Study;Pharmacotherapy;Phase;phase 1 study;Phase I Clinical Trials;phase I trial;Placebos;pre-clinical;preclinical development;Preclinical Drug Development;preclinical safety;Preparation;Private Sector;Process;Product Approvals;Production;Protocols documentation;Qualifying;Rattus;receptor;Recommendation;Regimen;research clinical testing;Respiratory Disease;Safety;safety study;Sampling;scale up;Serum;Smoker;Smoking;smoking cessation;Smoking Cessation Intervention;smoking exposure;Smoking treatment;standard of care;symptom treatment;Thromboangiitis Obliterans;timeline;Tissues;Tobacco;Tobacco Dependence;Tobacco smoke;Tobacco smoking behavior;Tobacco use;Toxicokinetics;Toxicology;varenicline;Vascular Diseases;Work

PROJECT_TITLE: IND-enabling Studies in Support of First in Human Safety Studies of a Novel Anti-Nicotine Human Monoclonal Antibody

STUDY_SECTION: NIDA

STUDY_SECTION_NAME: Medication Development Research Study Section[NIDA-L]


NIH_SPENDING_CATS: Diabetes

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE Insulin resistance is a key factor in the pathogenesis of type 2 diabetes, which affects more than 400 million people worldwide. This proposal aims to study the mechanism, regulation, and physiological function of spatiotemporal regulation of insulin signaling by key regulators of cell division. This research may establish uncontrolled loss of insulin receptor at the cell surface as a cause of insulin resistance in type 2 diabetes, and suggest novel therapeutic targets in treating this prevalent disease.

PI_NAMEs: CHOI, EUNHEE  (contact)

PROGRAM_OFFICER_NAME: GUPTA, DHANANJAY

PROJECT_TERMS: Affect;Animal Model;Animals;Attenuated;Binding;Biochemistry;blood glucose regulation;Cell division;Cell membrane;Cell surface;Cells;Cellular biology;Chemicals;Clathrin;Clathrin Adaptors;clinical application;clinical development;Complex;Cryoelectron Microscopy;Cultured Cells;Data;Defect;Diabetes Mellitus;Diet;Disease;DNA Sequence Alteration;Endocytosis;Endoplasmic Reticulum;enhancer-binding protein AP-2;Ensure;Feedback;FRAP1 gene;Genome Stability;Genomics;glucose metabolism;Goals;Growth;Hepatic;Homeostasis;Human;improved;in vivo;inhibitor;innovation;Insulin;Insulin deficiency;Insulin Receptor;insulin regulation;Insulin Resistance;insulin sensitivity;insulin signaling;Insulin Signaling Pathway;Knock-out;Lead;Link;lipid biosynthesis;lipid metabolism;Lipids;Liver;MAP Kinase Gene;Mediating;Mediator;Metabolic;Metabolic Control;Metabolic Diseases;metabolic phenotype;Metabolism;Mitosis;Mitotic;Molecular Target;mouse genetics;Mus;mutant;MXI1 gene;new therapeutic target;Non-Insulin-Dependent Diabetes Mellitus;Pathogenesis;Pathway interactions;Persons;Phosphorylation;Phosphotransferases;Physiological;Physiology;PIK3CG gene;Protein Tyrosine Phosphatase;Proto-Oncogene Proteins c-akt;PTPN1 gene;PTPN11 gene;Quality Control;receptor;Receptor Signaling;recruit;Regulation;Research;Resistance;Role;Signal Pathway;Signal Transduction;spatiotemporal;Structure;Testing;trafficking

PROJECT_TITLE: Spatiotemporal control of insulin signaling by mitotic regulators

STUDY_SECTION: CSRS

STUDY_SECTION_NAME: Cellular Signaling and Regulatory Systems Study Section[CSRS]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Neurosciences;Opioid Misuse and Addiction;Opioids;Pain Research;Prescription Drug Misuse;Substance Misuse

ORG_CITY: GAINESVILLE

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: NARRATIVE Oxycodone is consistently among the medications most widely prescribed for pain, but is also most widely abused and involved in overdose deaths, creating an urgent need for interventions that preserve oxycodone analgesia while curtailing its abuse potential. Research shows that the neuropeptide oxytocin has no recognized abuse potential, might reduce the abuse liability of opioids, and simultaneously has analgesic properties. The present study will determine if oxytocin will significantly reduce the abuse potential of oxycodone and experimental pain, which could lead to a novel therapeutic particularly among mid-age and older adults.

PI_NAMEs: BERRY, MEREDITH  (contact);CRUZ-ALMEIDA, YENISEL ;EBNER, NATALIE C

PROGRAM_OFFICER_NAME: RAMEY, TANYA S

PROJECT_TERMS: Absence of pain sensation;abuse liability;Acute Pain;addiction;addiction liability;Address;Adult;Age;Aging;Analgesics;analog;Animal Model;Animals;antinociception;behavioral economics;Behavioral Mechanisms;Biochemistry;Brain;Brain region;Cardiovascular system;chronic pain;conditioned place preference;Dose;Double-Blind Method;Drug Prescriptions;endogenous opioids;experience;Future;Health;Heroin;high risk;Hour;Human;human model;human old age (65+);Individual;Inflammation;Intervention;Intranasal Administration;Intravenous;Laboratory Study;Link;Literature;Mechanics;Mediator;medication for opioid use disorder;Methadone;middle age;Morbidity - disease rate;Morphine;mortality;multidisciplinary;multimodality;Mus;neurobiological mechanism;Neurons;Neuropeptides;novel;novel therapeutics;older adult;Older Population;Operative Surgical Procedures;Opioid;opioid abuse;opioid misuse;opioid mortality;opioid sparing;opioid use;opioid use disorder;Oral;overdose death;Oxycodone;Oxytocin;Pain;Pain management;Pain Measurement;pain model;pain reduction;pain sensitivity;Pathway interactions;Patients;Percocet;Pharmaceutical Preparations;Pharmacotherapy;Placebo Control;Placebos;Plasma;Population;pre-clinical;prescription opioid;prescription opioid addiction;preservation;Prevalence;prevent;Property;Public Health;Randomized;Rattus;Reducing Agents;Research;respiratory;response;Rewards;Scientific Advances and Accomplishments;Self Administration;Sensory;Source;Standardization;Stimulus;Stress;Structure;Substance Abuse Detection;substance use treatment;System;Testing;trend;volunteer

PROJECT_TITLE: The potential of oxytocin to reduce opioid abuse liability and pain among older adults

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Neurosciences;Substance Misuse

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE  This project seeks to increase our ability to accurately and reliably assess the clinically important construct of alcohol craving. Potential psychobiologic correlates of alcohol craving will be investigated which, if deemed reliable, may provide a much needed objective marker of craving to the field of addiction science. Further, the development of an ecologically valid virtual reality cue-exposure paradigm will advance our ability to induce craving in the laboratory and provide a platform by which future craving-related interventions can be tested.

PI_NAMEs: COURTNEY, KELLY ELIZABETH (contact)

PROGRAM_OFFICER_NAME: KERRIDGE, BRADLEY TOWNSEND

PROJECT_TERMS: addiction;Adult;alcohol abuse therapy;Alcohol consumption;alcohol craving;alcohol cue;alcohol exposure;Alcoholic beverage heavy drinker;Alcohols;Attention;attentional bias;Awareness;Basic Science;Biological Markers;Blinking;Clinical;Clinical Sciences;Clinical Trials;clinically relevant;Cognitive;Conscious;Corpus striatum structure;craving;cue reactivity;Cues;Development;Dopamine;effective therapy;Environment;Exhibits;experience;feasibility testing;follow-up;Foundations;Future;Goals;Guidelines;improved;innovation;interest;Intervention;Investigation;Laboratories;Maintenance;Measurement;Measures;Methods;National Institute on Alcohol Abuse and Alcoholism;Nature;novel;Participant;Pathogenesis;Patient Self-Report;Pharmaceutical Preparations;Pharmacological Treatment;Phenotype;Process;psychobiologic;psychologic;Psychophysiology;Reporting;Research;response;Sampling;Science;smartphone based assessment;substance use;Technology;Telephone;Testing;therapy development;Time;Treatment outcome;Validation;virtual reality;virtual reality environment;Visual;visual tracking

PROJECT_TITLE: The Use of Virtual Reality to Discover Objective Correlates of Alcohol Craving


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Social Determinants of Health

ORG_CITY: BLOOMINGTON

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: TRUSTEES OF INDIANA UNIVERSITY

ORG_STATE: IN

PHR: PROJECT NARRATIVE Despite significant investment in biomedical research to reduce the burden of Alzheimer’s disease and related dementias (ADRD) on individuals, their families, and society, most innovations generated have not been designed for scalability or implementation outside of research settings and are poorly diffused across the various healthcare delivery organizations. Over the past decade, an interdisciplinary team of scientists at Indiana University (IU) has developed and tested agile methods to design, implement, and diffuse evidence- based behavioral and social science interventions. In response to the NIA RFA-AG-22-010, the IU team is proposing to leverage its expertise in agile science to train the ADRD research workforce on agile methodologies for designing (Agile Innovation), implementing (Agile Implementation), and diffusing (Agile Diffusion) “nudges” to influence the behaviors of patients living with ADRD and both their care professionals and informal caregivers.

PI_NAMEs: BOUSTANI, MALAZ ;HOLDEN, RICHARD J (contact)

PROGRAM_OFFICER_NAME: NOVAK, PRISCILLA JOY

PROJECT_TERMS: Address;Adult;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease related dementia;anti-racism;Behavior;behavior change;behavior influence;Behavioral;behavioral and social science;behavioral economics;Biomedical Research;career;Caregivers;Caring;cohort;Collaborations;Complex;cost;Dementia;dementia care;design;Development;Diffuse;Diffusion;Disease;Diverse Workforce;E-learning;economic cost;education research;Educational Activities;Educational Curriculum;Engineering;Ethnic Origin;Evaluation;evidence base;experience;Family;Geography;Goals;graduate student;health care delivery;health disparity populations;health equity;Healthcare;Healthcare Systems;Human;human centered design;implementation intervention;improved;Indiana;Individual;informal caregiver;innovation;insight;interest;Intervention;Investments;Learning;Libraries;Medicine;Mentors;Methodology;Methods;Minority Groups;National Institute on Aging;open source;Patients;Performance;Persons;Postdoctoral Fellow;Problem Solving;Process;programs;Public Health;Publishing;Race;real world application;recruit;Reporting;Research;Research Personnel;Research Priority;Research Training;response;Science;Scientist;senior faculty;Services;skill acquisition;skills;skills training;social;Social Network;social organization;social science research;societal costs;Societies;Surveys;symposium;System;Techniques;Testing;theories;tool;Training;Underrepresented Minority;United States Centers for Medicare and Medicaid Services;United States Dept. of Health and Human Services;United States National Academy of Sciences;United States National Institutes of Health;Universities;virtual;Woman

PROJECT_TITLE: The Agile Nudge University Program


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Cancer;Immunotherapy;Lung;Nanotechnology;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: Cell-based immunotherapies have emerged as an exciting new approach to cancer therapy, but they remain limited by an inability to visualize the biodistribution of cells after administration. In this project, we will develop new methods for labeling and imaging Natural Killer (NK) cells that will permit accurate characterization of their biodistribution in the lungs with high sensitivity.

PI_NAMEs: BANKSON, JAMES A;SOKOLOV, KONSTANTIN V (contact)

PROGRAM_OFFICER_NAME: LIN, CHARLES

PROJECT_TERMS: absorption;Address;Adoptive Transfer;Affect;Allogenic;amphiphilicity;anatomic imaging;Anatomy;Animals;Antigens;Biodistribution;biomedical imaging;Biopsy;cancer therapy;Cell Culture Techniques;Cell Therapy;Cells;cellular imaging;Cellular immunotherapy;Chemicals;Child;Childhood Cancer Treatment;Clinic;Clinical;clinical translation;cost;cytotoxicity;density;detection sensitivity;Development;electronic cigarette use;Erythrocytes;Excision;FDA approved;feasibility testing;Fluorocarbons;Foundations;Gases;Goals;Image;imaging approach;imaging biomarker;Imaging Device;imaging modality;Immune;immune imaging;Immunotherapy;improved;in vivo;Infusion procedures;Inhalation;innovation;insight;interest;iron oxide nanoparticle;Kinetics;Label;Logistics;Lung;lung imaging;Magnetic Resonance Imaging;Malignant Neoplasms;metabolic imaging;Metastatic Neoplasm to the Lung;Methods;migration;Modality;Modeling;Monitor;mortality;nanoDroplet;Natural Killer Cell Immunotherapy;Natural Killer Cells;Neoplasm Metastasis;NK cell therapy;non-invasive imaging;novel strategies;nuclear imaging;Osteosarcoma;Patients;pediatric patients;Phase I Clinical Trials;Physiology;Plasma;Positron-Emission Tomography;Protocols documentation;Radiation;Radiation Dose Unit;Recurrence;Refractory;Reporting;Resolution;respiratory gas;respiratory imaging;Respiratory physiology;response;Safety;Sensitivity and Specificity;serial imaging;soft tissue;Solid Neoplasm;Structure of parenchyma of lung;success;superparamagnetism;T-Lymphocyte;Technology;Therapeutic;Time;Tissues;Tracer;translatable strategy;Treatment Failure;tumor;Validation;Visualization;volunteer;Water

PROJECT_TITLE: Hyperpolarized 129Xe MRI for imaging NK cell therapy of lung metastasis

STUDY_SECTION: IPCA

STUDY_SECTION_NAME: Imaging Probes and Contrast Agents Study Section[IPCA]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Aging;Atherosclerosis;Cardiovascular;Climate-Related Exposures and Conditions;Heart Disease;Social Determinants of Health

ORG_CITY: LOUISVILLE

ORG_NAME: UNIVERSITY OF LOUISVILLE

PHR: Chronic exposure to ambient particulate matter (PM) leads to systemic inflammation and cardiovascular disease. Promoting the endogenous active mechanisms of resolution may interrupt persistent inflammatory inputs induced by PM. Here, we will assess the impacts of PM exposure on the cellular facilitators of resolution and determine whether their response to PM governs systemic immunity.

PI_NAMEs: SANSBURY, BRIAN EDWARD (contact)

PROGRAM_OFFICER_NAME: NADADUR, SRIKANTH

PROJECT_TERMS: Acceleration;Address;Adoptive Transfer;Affect;Air Pollution;Apolipoprotein E;Applied Research;Arachidonate 15-Lipoxygenase;Atherosclerosis;Biological;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;cell type;Cells;Chronic;Complex;Contracts;Coronary Arteriosclerosis;cytokine;Development;Disease;Disease Progression;Engraftment;Enzymes;Erythrocytes;Erythrophagocytosis;Event;Excision;exhaustion;Exposure to;fine particles;FPR2 gene;fundamental research;Genetic Transcription;Goals;Hematologic Neoplasms;Hematopoiesis;Hematopoietic;Hematopoietic stem cells;Heme;Homeostasis;Homing;immune function;Immune response;Immunity;Impairment;in vivo;Individual;Infection;Inflammation;Inflammation Process;Inflammatory;interest;Interruption;Investigation;Iron;Knockout Mice;Lead;Leukocytes;Life;life span;Link;lipid mediator;Macrophage;Maintenance;Maps;Measures;Mediating;Mediator;Metabolism;monocyte;multiorgan injury;Mus;Myelogenous;Myelopoiesis;Organ;oxidative damage;Particulate;Particulate Matter;Pathology;Pathway interactions;Patients;Phase;Play;Population;Premature aging syndrome;prevent;Process;Production;programs;Property;receptor;Resolution;response;Risk;Role;senescence;Signal Transduction;single-cell RNA sequencing;Site;Spleen;spleen transplantation;Splenectomy;Splenic Red Pulp;Stimulus;Systemic disease;Testing;Tissues;Up-Regulation;uptake;vascular inflammation;Work

PROJECT_TITLE: Role of Splenic Pro-Resolving Mediators During Exposure to Particulate Air Pollution

STUDY_SECTION: SIEE

STUDY_SECTION_NAME: Systemic Injury by Environmental Exposure[SIEE]