NIH_SPENDING_CATS: Aging;Bioengineering;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Social Determinants of Health

PI_NAMEs: BANERJEE, SAMPRIT  (contact)

PROJECT_TERMS: aging and technology;Archives;Artificial Intelligence;Attitude;Biometry;Cellular Phone;Center for Translational Science Activities;Clinical Sciences;Cognitive;cognitive ability;Collaborations;Collection;Computer Assisted;Computer software;Computers;Consultations;cyber security;Data;Data Collection;data exchange;data library;data management;data sharing;data standards;design;Development;Documentation;Education;Electronics;Enhancement Technology;Ensure;experience;Florida;Guidelines;handheld mobile device;Health;health management;Human Resources;Illinois;Impaired cognition;Industry;Infrastructure;instrument;integration site;intelligent personal assistant;Internet;Leadership;Machine Learning;Maintenance;Manuals;Manuscripts;Measures;Medicine;member;Methods;Monitor;new technology;novel;Occupations;older adult;Participant;Pharmaceutical Preparations;Pilot Projects;Play;Preparation;Privacy;Procedures;programs;Progress Reports;Protocols documentation;psychosocial;Publications;Quality Control;Recommendation;Recording of previous events;recruit;Reporting;repository;Research;Research Activity;Research Design;Research Personnel;Research Project Grants;research study;Research Support;Resource Sharing;Resources;Role;Safety;Sampling;Security;Side;Site;Social isolation;Social support;sociodemographics;software development;Source;Statistical Data Interpretation;Structure;structured data;Surveys;System;Tablets;Technical Expertise;Techniques;Technology;technology development;Telephone Interviews;Testing;tool;Training;United States National Institutes of Health;Universities;Update;Vendor;virtual reality;Work

PROJECT_TITLE: Data and Technical Development Core


ADMINISTERING_IC: AG

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biotechnology

ORG_CITY: NEW YORK

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PI_NAMEs: ROGERS, WENDY A (contact)

PROJECT_TERMS: Achievement;Adult;Age;Aging;aging and technology;American Psychological Association;Award;Awareness;Benchmarking;Book Chapters;Books;Businesses;career;Categories;Communication;Communication Tools;Communities;Creativeness;design;Development;digital divide;Discipline;Disparity;dissemination strategy;Education;Educational workshop;Effectiveness;Elements;Emerging Technologies;Enhancement Technology;Ensure;ergonomics;Evaluation;Family;Family member;Federal Government;General Population;Gerontology;Goals;Government Agencies;Guidelines;Health;health disparity;Health Personnel;Healthcare;Human;Human Resources;Illinois;Impaired cognition;implementation facilitation;improved;Individual;Industry;Influentials;innovation;innovative technologies;Interdisciplinary Study;interest;International;Internet;Internships;journal article;Journals;Knowledge;Local Government;Mentors;Methodology;Methods;Mission;Monitor;news;novel;older adult;Older Population;Outcome;outreach;Paper;Peer Review;Personal Satisfaction;podcast;Policies;Policy Maker;Prize;Procedures;Productivity;Professional Organizations;programs;Protocols documentation;Psychology;Publications;Publishing;Quality of life;Recommendation;Research;Route;Safety;Science;Scientist;Series;social;social engagement;social media;Societies;Stereotyping;Structure;Students;success;symposium;Techniques;technological innovation;Technology;tool;Translating;Translations;web site;webinar;Woman;Work;Workplace

PROJECT_TITLE: Dissemination Core


ADMINISTERING_IC: AA

ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Racial and Ethnic Minority Health Research;Rehabilitation;Rural Health;Social Determinants of Health;Substance Misuse

ORG_CITY: WALTHAM

ORG_DEPT: MISCELLANEOUS

ORG_NAME: BRANDEIS UNIVERSITY

ORG_STATE: MA

PHR: This study will examine Medicaid health plan policies related to delivery and management of alcohol use disorder treatment and their relationship with access to and outcomes of care for racial/ethnic minorities, women and rural Americans. Findings from this study will help health plan administrators as they develop and implement plan policies, state Medicaid directors as they contract with health plans, and federal policy makers making decisions about Medicaid policy, to help improve access to alcohol treatment.

PI_NAMEs: STEWART, MAUREEN T (contact)

PROGRAM_OFFICER_NAME: WHITAKER, DAMIYA EVE

PROJECT_TERMS: access disparities;addiction;Address;Administrator;alcohol abuse therapy;alcohol availability;Alcohol consumption;alcohol misuse;alcohol use disorder;alcohol-related death;Alcohols;American;Area;barrier to care;Behavior Therapy;behavioral health;binge drinking;care outcomes;Caring;Contracts;cost;COVID-19;Data;Decision Making;design;Disparity;District of Columbia;Emergency department visit;Equilibrium;ethnic minority;Ethnic Origin;Evidence based treatment;experience;FDA approved;federal policy;follow-up;Gender;Geography;Goals;Health;health care service;health disparity;Health Insurance;health management;health plan;Health Services;Health Services Accessibility;Hospitalization;Improve Access;improved;innovation;Insurance Benefits;Link;Mainstreaming;Managed Care;Managed Care Programs;Medicaid;Medical;Morbidity - disease rate;mortality;Organizational Policy;Outcome;outcome disparities;Patients;Pharmaceutical Preparations;Pharmacotherapy;Police;Policies;Policy Maker;Population;programs;provider networks;Qualifying;Race;racial difference;racial minority;Regulation;Reporting;response;Rural;rural Americans;rural area;rural setting;social health determinants;social stigma;success;Surveys;tool;Treatment Cost;Treatment outcome;treatment services;United States;waiver;Woman

PROJECT_TITLE: Alcohol treatment in Medicaid managed care plans: Disparities in policies and outcomes


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Dementia;Networking and Information Technology R&D (NITRD);Neurodegenerative;Rehabilitation

PI_NAMEs: CHARNESS, NEIL  (contact)

PROJECT_TERMS: Adult;Aging;aging and technology;aging population;Alzheimer's Disease;Alzheimer's disease related dementia;Area;Attitude;Cognition;Cognitive;cognitive ability;cognitive rehabilitation;Communication;Controlled Study;COVID-19 pandemic;Creativeness;cybersickness;Data;design;Development;Education;Emotional;Enhancement Technology;Ethnic Origin;Evaluation;evidence base;experience;Exposure to;Focus Groups;Fostering;Guidelines;Health;Healthcare;heuristics;Home;Immersion;Impaired cognition;impression;improved;Individual Differences;information gathering;innovation;Instruction;Life;Link;Loneliness;Marketing;Measures;Mediating;Mediator;mild cognitive impairment;Modeling;mortality risk;Museums;older adult;Outcome;Participant;Personal Satisfaction;Phase;phase 1 designs;Physical Function;Population;Population Heterogeneity;preference;prevent;programs;Protocols documentation;Quality of life;Randomized;randomized trial;Rehabilitation therapy;Research;Research Personnel;Resources;Risk;Safety;Sampling;Services;Site;social;social engagement;Social Interaction;Social isolation;Social support;Socialization;structured data;System;Tablets;Technology;technology development;Testing;therapy development;Time;Training;United States National Institutes of Health;usability;virtual;virtual reality;virtual reality environment;virtual reality intervention;virtual reality system;virtual technology

PROJECT_TITLE: Project 1: Virtual Reality to Support Cognitive Health and Engagement and Socialization Among Aging Adults


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Neurosciences;Post-Traumatic Stress Disorder (PTSD)

ORG_CITY: STANFORD

ORG_DEPT: PSYCHIATRY

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: PROJECT NARRATIVE The utilization of brain biomarkers for the diagnosis and treatment planning of PTSD is hindered by the inaccessibility of affordable brain imaging technology. Access to cost effective and portable brain imaging technology would represent a transformative step for PTSD research and clinical work. I propose to develop novel brain imaging methods that enable the assessment of PTSD brain biomarkers in an affordable, portable, and repeated manner.

PI_NAMEs: BALTERS, STEPHANIE  (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: 3-Dimensional;accurate diagnosis;acute stress;Address;Adult;Affect;American;Amygdaloid structure;Area;Assessment tool;Behavioral;Biological Markers;Brain;Brain imaging;Brain region;Breathing;career;career development;Career Mobility;career preparation;Characteristics;Chronic stress;Clinical;cohort;Collaborations;Complex;cost;cost effective;Cross-Sectional Studies;Data Set;Development;Development Plans;Diagnosis;Disease;Doctor of Philosophy;emotion regulation;Emotional;Emotions;Engineering;Environment;experience;feasibility testing;forging;Foundations;Functional disorder;Functional Magnetic Resonance Imaging;functional near infrared spectroscopy;Funding;Future;Galvanic Skin Response;Gaussian model;Goals;heart rate variability;Hippocampus;Hydrocortisone;imaging biomarker;imaging modality;Imaging technology;improved;Individual;innovation;Intervention;Interview;Knowledge;Laboratories;Licensing;machine learning algorithm;Magnetic Resonance Imaging;Measurement;Measures;men;Methods;Monitor;multidisciplinary;Neurobiology;neuroimaging;Neurosciences;novel;optimal treatments;Outcome;Pathogenesis;Pathway interactions;Pattern;Persons;Population;portability;Positioning Attribute;post-doctoral training;Post-Traumatic Stress Disorders;Precision Health;precision medicine;Prefrontal Cortex;Prognosis;Psychophysiology;Research;research and development;research faculty;Research Personnel;response;Salivary;Science;Scientist;Secure;sensor;Severities;Signal Transduction;skills;Stimulus;Stress;success;symptomatic improvement;Symptoms;Technology;Testing;Training;trait;Trauma;trauma exposure;Treatment outcome;treatment planning;United States National Institutes of Health;Universities;Validation;Woman;Work

PROJECT_TITLE: Towards elucidating PTSD pathogenesis with ultra-portable and low-cost neuroimaging


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics

ORG_CITY: Columbus

ORG_DEPT: CHEMISTRY

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative This MIRA application seeks to uncover the specific functions of a growing family of trans-editing proteins that play a universal role in maintaining the fidelity of protein synthesis. Our knowledge of the broader physiological functions of these proteins, especially in eukaryotes, will be addressed in this work. The therapeutic potential of trans-editing domains has not been exploited and represents another major gap in the field that we hope to address by our planned studies.

PI_NAMEs: MUSIER-FORSYTH, KARIN M (contact)

PROGRAM_OFFICER_NAME: CZAPLINSKI, KEVIN

PROJECT_TERMS: Address;Amino Acids;Amino Acyl-tRNA Synthetases;Aminoglycosides;Area;Bacteria;Cell Survival;Cells;deacylation;design;Drug Combinations;Eukaryota;Family;Genes;Genetic Code;Goals;Homologous Gene;In Vitro;infancy;knock-down;Knowledge;knowledge base;Lead;new therapeutic target;novel;pathogen;Physiological;Play;Process;proline-tRNA;Protein Biosynthesis;protein function;Protein Synthesis Inhibitors;Proteins;Quality Control;Research;Ribosomes;Role;Shapes;Solid;Structure;Therapeutic;therapeutically effective;Transfer RNA;Work

PROJECT_TITLE: Translational quality control by trans-editing domains

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-S(55)R]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: MIDDLETOWN

ORG_NAME: WESLEYAN UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative: The proposed research is relevant to the public health because more than 6 million Americans are currently living with Alzheimer's disease and desperately need life-improving therapeutics. Upon conclusion, we will provide the Alzheimer's research community with a new source of disease-causing Ab and tau oligomers and direct new targeting therapies by defining the structural components of a toxic oligomer. Additionally, we will build a tool to describe complex intercellular network responses to Ab and tau oligomers opening yet another line of therapeutic discovery.

PI_NAMEs: O'NEIL, ALISON LINSLEY (contact)

PROGRAM_OFFICER_NAME: YANG, AUSTIN JYAN-YU

PROJECT_TERMS: 3-Dimensional;abeta accumulation;abeta oligomer;Affect;alpha synuclein;Alzheimer's Disease;Alzheimer's disease patient;American;Amyloid beta-Protein;Animals;Astrocytes;Autopsy;Bar Codes;Biochemical;Biological Assay;Brain;brain cell;brain tissue;Cell Survival;cell type;Cells;Circular Dichroism Spectroscopy;Clinic;Communities;Complementary DNA;Complex;Data Set;design;Development;Disease;Dissociation;Drops;Drug Screening;Early Intervention;early onset;Economic Burden;Elements;experimental study;Exposure to;Genetic;Genetic Transcription;Goals;Grant;gray matter;Health;Human;human disease;Human Genetics;hyperphosphorylated tau;Image;imaging modality;improved;In Vitro;in vitro Model;indexing;induced pluripotent stem cell;Induced pluripotent stem cell derived neurons;induced pluripotent stem cell technology;innovation;insight;intercellular communication;Interneurons;Length;Life;light scattering;Link;Lipids;Mass Spectrum Analysis;Measures;Mentorship;Methodology;Methods;Microglia;Modeling;Molecular Sieve Chromatography;Mutation;Nerve Degeneration;Neurites;Neurodegenerative Disorders;Neuroglia;neuronal cell body;Neurons;neurotoxic;new therapeutic target;Nucleotides;operation;Organoids;Parkinson Disease;Pathologic;patient - derived stem cells;patient derived induced pluripotent stem cells;Patients;Population;Post-Translational Protein Processing;Production;protein aggregation;protein oligomer;Proteins;Public Health;Reproducibility;Research;Research Personnel;research study;response;RNA;screening;single-cell RNA sequencing;socioeconomics;Source;stem cell model;stem cells;Structure;Structure-Activity Relationship;success;Symptoms;System;targeted treatment;tau aggregation;tau Proteins;Techniques;Testing;Therapeutic;therapeutic development;Therapeutic Intervention;Tissues;tool;Toxic effect;transcriptomics;uptake

PROJECT_TITLE: Exploiting Alzheimer's disease patient-derived stem cells to biochemically define tau and amyloid-beta oligomer toxic features and their downstream cellular effects


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Prevention;Rehabilitation;Social Determinants of Health

PI_NAMEs: BOOT, WALTER RICHARD (contact)

PROJECT_TERMS: Acceleration;Activities of Daily Living;Adult;Age;Aging;aging and technology;Alzheimer's Disease;Alzheimer's disease related dementia;Area;Attitude;Behavioral Model;care providers;Cognition;Cognitive;cognitive ability;cognitive function;cognitive performance;cognitive rehabilitation;cognitive testing;cognitive training;Communities;Computer software;Data;Dementia;design;Deterioration;diagnostic algorithm;Education;effective intervention;Electronic Mail;Emotional;Enhancement Technology;Evaluation;experience;Feeling;Focus Groups;functional improvement;functional independence;Goals;hands-on learning;Health;human old age (65+);Impaired cognition;implementation barriers;improved;Individual;information gathering;innovation;innovative technologies;insight;instrumental activity of daily living;Interview;iterative design;Knowledge;Language;Link;Measures;Memory;Methods;mild cognitive impairment;Modeling;multi-component intervention;normal aging;older adult;Older Population;Outcome;Perception;Performance;Personal Satisfaction;Persons;Pharmacological Treatment;Phase;phase 1 study;pilot test;Population;post intervention;preference;prevent;preventive intervention;Production;Protocols documentation;Quality of life;Randomized;Research;Research Personnel;Resources;Risk;Sampling;Secondary Prevention;Site;social;social engagement;Social isolation;Social support;Speech;Surveys;System;Systems Development;Tablets;Technology;technology intervention;technology validation;Testing;therapy development;Time;tool;Training;Training Programs;United States National Institutes of Health;usability;user centered design;Videoconferencing;Waiting Lists

PROJECT_TITLE: Project 2: Technology Support for Cognition and Social Engagement for Aging Adults with Mild Cognitive Impairment (MCI)


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Congenital Structural Anomalies;Genetics;Kidney Disease;Pediatric;Polycystic Kidney Disease

ORG_CITY: CHICAGO

ORG_DEPT: PHARMACOLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Mutations in PKD2 cause many forms of autosomal dominant polycystic kidney disease (ADPKD). PKD2 forms an ion channel in primary cilia of the collecting duct and aberrant cilia Ca2+ is proposed to initiate cyst formation. We propose Ca2+ regulates PKD2 function though sites commonly mutated in the ADPKD population. We have developed novel tools to study the structural and functional biophysics of cilia PKD2— which yield results in real-time, at super and atomic resolution– thereby providing the most accurate description of the disease- causing mechanism involved in cilia Ca2+-dependent gene expression changes during cyst formation.

PI_NAMEs: DECAEN, PAUL GREGORY (contact)

PROGRAM_OFFICER_NAME: MARIC-BILKAN, CHRISTINE

PROJECT_TERMS: Affinity;Attenuated;Autosomal Dominant Polycystic Kidney;Binding;Binding Sites;Biological Assay;Biophysical Process;Biophysics;Body System;C-terminal;Calcium;Cell Maintenance;Cell Polarity;Cell Separation;Cells;Charge;Cilia;ciliopathy;comorbidity;Confocal Microscopy;CRISPR/Cas technology;Cryoelectron Microscopy;Cyst;Cystic kidney;Data;desensitization;design;Development;Disease;Disease Progression;disease-causing mutation;Disparate;Duct (organ) structure;Ductal Epithelium;EF Hand Motifs;Electrophysiology (science);Exhibits;experimental study;Family;Future;Gene Expression;Genes;Genetic;Genetic Transcription;Germ-Line Mutation;Hand;Human;Human body;in vivo;innovation;Ion Channel;Kidney;Kidney Failure;Measurement;Measures;Mediating;member;Mendelian disorder;Methodology;Modality;Molecular;Molecular Conformation;Movement;mutant;Mutate;Mutation;Nephrectomy;novel;Organ;Organelles;Outcome;Pathogenicity;Patients;Pharmaceutical Preparations;Physiological;PKD2 gene;Polycystic Kidney Diseases;Population;Probability;Process;Publishing;receptor;Regulation;Reporting;Resolution;sensor;Signal Transduction;Site;Structure;superresolution imaging;superresolution microscopy;Testing;Time;Tissues;tool;trafficking;treatment strategy;Visceral;voltage

PROJECT_TITLE: Cilia calcium dysregulation in polycystic kidney disease

STUDY_SECTION: CSRS

STUDY_SECTION_NAME: Cellular Signaling and Regulatory Systems Study Section[CSRS]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Machine Learning and Artificial Intelligence;Neurodegenerative

PI_NAMEs: SHARIT, JOSEPH  (contact)

PROJECT_TERMS: Adopted;Adult;Age;Aging;aging and technology;archived data;Area;Artificial Intelligence;behavior observation;care costs;Caregiver support;Cognitive;cognitive ability;cognitive load;cognitive task;comparative;Comprehension;cost;Data Set;Decision Aid;Decision Making;design;Development;disability;Disease Management;Drug Prescriptions;Education;Effectiveness;efficacy evaluation;Enhancement Technology;Ensure;Environment;Ethnic Origin;Evaluation;Expenditure;experience;Face;Goals;Health;health care cost/financing;Health Expenditures;health literacy;health management;Health system;Healthcare;Human;human old age (65+);Illinois;Impaired cognition;Improve Access;Individual;Individual Differences;innovation;Insurance;intelligent personal assistant;Internet;Interview;Investments;iterative design;Knowledge;Long-Term Care;low socioeconomic status;mathematical ability;Mediation;Mediator;medical appointment;Medicare;Methods;mild cognitive impairment;novel;older adult;Older Population;online resource;Participant;Performance;Personal Satisfaction;Persons;Phase;Population Heterogeneity;preference;prevent;Process;Protocols documentation;Race;Randomized;Reporting;Research;Resources;Rights;Sampling;Self Management;Services;Site;skills;sound;Source;Specific qualifier value;Structure;System;task analysis;Task Performances;Techniques;Technology;tool;Training;usability;user centered design;web site;Work

PROJECT_TITLE: Project 3: Technology Tools for Cognitive Support for Health Management Activities for Aging Adults with and without Mild Cognitive Impairment


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research

ORG_DEPT: NEUROLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: NARRATIVE The NIA-Alzheimer’s Disease Family Based Study (NIA-AD FBS) has created a resource of 1,756 well- characterized families, 42.4% of whom are from under-represented race/ethnic group and that includes 8,697 consented family members and 1,096 unrelated controls with regular follow up. We have expanded sample acquisition to meet the changing needs of research on Alzheimer’s disease and related disorder, store all biological samples at the National Centralized Repository for Alzheimer's Disease at Indiana University and share all clinical, biomarker and genetic data acquired or generated through the National Institute on Aging Genetics of Alzheimer’s Disease Storage. The central goal of the NIA-AD FBS is to support research by making clinical data, samples and data generated from the samples broadly available to the AD research community.

PI_NAMEs: BEECHAM, GARY WAYNE;FOROUD, TATIANA M.;GOATE, ALISON M;MAYEUX, RICHARD P (contact);REITZ, CHRISTIANE

PROGRAM_OFFICER_NAME: BENNANI-BAITI, MICHAEL

PROJECT_TERMS: 3-Dimensional;Adult Children;Affect;African American;African American population;Age;Aliquot;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer’s disease biomarker;Asian;Asian Americans;Autopsy;Biological;Biological Assay;Biological Markers;Blood;blood-based biomarker;Brain;brain tissue;C9ORF72;Caribbean Hispanic;Cells;Cellular Phone;Central America;Cerebrovascular Disorders;Clinical;Clinical Data;clinical diagnosis;clinical research site;cohort;Collection;Communities;Consent;COVID-19 pandemic;Data;data sharing;data sharing networks;Diagnosis;DNA;DNA Methylation;Drug Targeting;Early Onset Alzheimer Disease;Early Onset Familial Alzheimer's Disease;Elderly;Ethics;ethnic diversity;Ethnic Population;exome;Family;Family member;Family Study;follow up assessment;follow-up;Freezing;functional genomics;Future;Genetic;Genetic Counseling;Genetic Diseases;genetic information;Genetic study;genetic variant;genome sequencing;genome wide association study;genome-wide;Genotype;Geography;Goals;Grant;Heritability;improved;Indiana;Individual;International;Late Onset Alzheimer Disease;Latinx;Light;Medical;Methods;Mexican Americans;Molecular Profiling;multi-ethnic;multiple omics;Mutation;Names;National Institute on Aging;neurofilament;neuropathology;non-demented;Not Hispanic or Latino;novel strategies;offspring;Onset of illness;outreach;Participant;Penetrance;Peripheral Blood Mononuclear Cell;Persons;phenotypic data;Plasma;predictive modeling;Prefrontal Cortex;presenilin-1;presenilin-2;Principal Investigator;Protocols documentation;Publications;racial diversity;racial population;Recommendation;recruit;Reporting;repository;Research;research clinical testing;Research Personnel;research study;Research Support;Resources;Risk;Risk Factors;Sampling;screening;Services;Site;SNP array;social media;South America;tau Proteins;tau-1;Technology;Telecommunications;Tissues;transcriptome sequencing;Travel;U-Series Cooperative Agreements;Universities;Variant;Venous blood sampling;virtual visit;Visit;web app;whole genome;Work;working group

PROJECT_TITLE: National Institute on Aging Alzheimer's Disease Family-Based Study (NIA-AD FBS)


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Data Science;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Social Determinants of Health

ORG_CITY: GAINESVILLE

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE To comprehensively understand the causes of diseases and prevent them, environmental exposures, especially the spatial and contextual exposome—social and ecological contexts in which the person lives their life (e.g., social capital, climate) or external agents to which the one is exposed (e.g., environmental pollutants), need to be systematically explored. There is also an increasing interest in spatiotemporally linking spatial and contextual exposome data, especially contextual social determinants of health (SDoH), to real-world observational data including electronic health records (EHRs) and administrative claims data, to answer various questions on how exposures to environmental factors affect health status, disease development and outcomes, and health disparities and equity. Responding to RFA-ES-23-002, the objective of this proposal is to develop an innovative SPATIAL AND CONTEXTUAL EXPOSOME SEMANTIC DATA INTEGRATION SYSTEM (SPACESCANS) with (1) an ontology-annotated knowledge graph of existing publicly available high-quality spatial and contextual exposome data from heterogeneous sources, along with (2) a user-friendly data integration tool.

PI_NAMEs: BIAN, JIANG  (contact);HU, HUI ;TAO, CUI

PROGRAM_OFFICER_NAME: DUNCAN, CHRISTOPHER GENTRY

PROJECT_TERMS: Adopted;Adoption;Advisory Committees;Affect;Age;aging related disease;Alzheimer's Disease;Alzheimer's disease related dementia;analytical method;Artificial Intelligence;Automobile Driving;Catalogs;Characteristics;Chronic;Climate;clinical data warehouse;Clinical Research;Collection;Communities;Complex;computerized data processing;Confusion;Data;Data Discovery;data integration;data registry;data resource;Data Set;Data Sources;data standards;design;Development;Diabetes Mellitus;Disease;Electronic Health Record;electronic health record system;Ensure;Environment;Environmental Exposure;Environmental Pollutants;Environmental Risk Factor;Equity;Exposure to;gene environment interaction;Genetic;Goals;Health;health disparity;health equity;Health Insurance Portability and Accountability Act;Health Status;Heterogeneity;heterogenous data;Individual;Infrastructure;innovation;interest;knowledge graph;Life;Link;Machine Learning;Manuals;metadata standards;Methods;Modeling;multidisciplinary;novel;Online Systems;Ontology;operation;Outcome;outcome disparities;parallelization;patient oriented;Patient-Focused Outcomes;Patients;Persons;Phenotype;prevent;Process;Research;Research Infrastructure;Research Personnel;Resources;Semantics;social;social capital;social health determinants;Software Engineering;Source;spatial integration;spatiotemporal;Standardization;success;System;Systems Integration;Testing;Texas;tool;Universities;usability;user centered design;user-friendly;web based interface;Work

PROJECT_TITLE: Semantics Standards and Tools for Spatial and Contextual Exposome Data

STUDY_SECTION_NAME: Special Emphasis Panel[ZES1 BWD-D (HS)]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: SEATTLE

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE The goal of the UW MSTP is to train a diverse cohort of physician-scientists capable of bridging the gap between basic scientific research and its translation to clinical practice. During their training, students have made important contributions to medical science, helping to improve the health of all people. After graduation, trainees continue to advance medical knowledge and its application, as they assume leadership positions distributed throughout the biomedical research workforce.

PI_NAMEs: HORWITZ, MARSHALL S. (contact)

PROGRAM_OFFICER_NAME: AKACEM, LAMEESE DANA

PROJECT_TITLE: University of Washington Medical Scientist Training Program

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - A[TWD-A]


NIH_SPENDING_CATS: Biotechnology;Genetics;Physical Injury - Accidents and Adverse Effects

ORG_CITY: BALTIMORE

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: PROJECT NARRATIVE Trauma-associated inflammation and organ injuries remain a leading cause of death each year in the United States. In this research program, we seek to investigate the function and mechanism of extracellular RNAs in innate immunity activation and organ injury after trauma. We expect that our research will provide a new type of therapeutic target for trauma treatment.

PI_NAMEs: ZOU, LIN  (contact)

PROGRAM_OFFICER_NAME: ZHAO, XIAOLI

PROJECT_TERMS: Adoptive Cell Transfers;antagonist;Attenuated;Blunt Trauma;Cause of Death;cell injury;Cessation of life;chemokine;clinical care;cytokine;Data;disability;extracellular;Foundations;Future;Genetic;Genetically Modified Animals;Human;Immune;immune activation;improved;Inflammation;inhibitor;insight;Intervention;Literature;locked nucleic acid;Macrophage;MicroRNAs;Modeling;Molecular;mortality;Mus;Natural Immunity;Necrosis;novel;novel therapeutic intervention;Nucleic Acids;Oligonucleotides;organ injury;Organ Preservation;Pattern;pharmacologic;Plasma;Production;programs;receptor;Research;RNA;Role;secondary infection;sensor;Signal Transduction;Small RNA;Testing;therapeutic target;Tissues;TLR7 gene;transcriptome sequencing;Trauma;trauma care;Trauma patient;Traumatic injury;United States

PROJECT_TITLE: Extracellular nucleic acids in trauma innate immunity

STUDY_SECTION: MRAD

STUDY_SECTION_NAME: Maximizing Investigators' Research Award - D Study Section[MRAD]


NIH_SPENDING_CATS: Bioengineering;Data Science;Networking and Information Technology R&D (NITRD);Social Determinants of Health

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE To better understand the effects environmental exposures such as air pollution on health, scientists must bring together varied types of data from sensors, along with information about where and when it was collected. Currently, we lack informatics tools that enable researchers to share, find, assess, and re-use environmental exposure data. Here, we will create tools that help research teams more easily conduct health research related to environmental exposures, using sensors.

PI_NAMEs: CUMMINS, MOLLIE R.;GOURIPEDDI, RAMKIRAN  (contact)

PROJECT_TERMS: Air Pollution;Architecture;Collection;Communication;Communities;Community Developments;community engagement;Companions;Consensus;Data;Data Collection;Data Discovery;data harmonization;data library;data management;data reuse;Data Set;data sharing;Data Sources;design;Devices;Documentation;Ecosystem;Environmental Exposure;Environmental Health;Event;experience;Extensible Markup Language;Generations;Goals;Health;health data;Human;Informatics;informatics infrastructure;informatics tool;insight;Metadata;metadata standards;Methods;Modeling;open source;operation;Outcome;Process;Property;prototype;Public Health Informatics;Published Comment;Publishing;Records;repository;Reproducibility;Research;research and development;Research Personnel;Sampling;Scientist;Semantics;sensor;spatiotemporal;Specific qualifier value;System;tool;Universities;usability;user centered design;Utah;Work

PROJECT_TITLE: Community-Driven Sensor Metadata Ecosystem for Exposure Health


NIH_SPENDING_CATS: Data Science;Foodborne Illness;Networking and Information Technology R&D (NITRD);Social Determinants of Health

ORG_CITY: NEW HAVEN

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: YALE UNIVERSITY

PHR: Project Narrative There is a great desire by the exposure science, epidemiology, and data science communities to use data and metadata standards to accelerate environmental research workflow, gain new knowledge, and increase data reuse. Bringing this desire to fruition requires the development of a set of community-driven standards for describing environmental exposures and linking them to human health and disease related data. Although our proposal focuses on the water contamination domain, the proposed approach is transferrable to other environmental health sciences domains.

PI_NAMEs: CHEUNG, KEI-HOI  (contact)

PROJECT_TERMS: Acceleration;Adopted;Adoption;Biological;Chemicals;Chronic;Classification;Collaborations;Common Data Element;Communities;community setting;complex data;contaminated drinking water;contaminated water;Data;data harmonization;data integration;data modeling;data reuse;Data Science;Data Scientist;data standards;design;Development;Disease;drinking water;Educational workshop;Electronics;Environment;Environmental Engineering technology;Environmental Exposure;Environmental Health;Environmental Science;Epidemiology;Evaluation;exposed human population;Exposure to;FAIR principles;Feedback;Foundations;Graph;Guidelines;Health;health data;health science research;Human;human disease;implementation tool;interest;Journals;Knowledge;knowledge graph;Link;Literature;Malignant Neoplasms;Maps;Measurable;Measures;meetings;Metadata;metadata standards;Modeling;multidisciplinary;National Institute of Environmental Health Sciences;Natural Language Processing;Neurologic;Ontology;personal care products;Persons;Pesticides;Plastics;Population;programs;Public Health;Published Comment;Publishing;PubMed;Questionnaires;Readability;Reporting;repository;reproductive;Research;Research Personnel;Science;Social Network;Software Tools;Structure;Surveys;systematic review;Techniques;Teleconferences;tool;United States National Institutes of Health;usability;Vertebral column;Water Pollutants;Work

PROJECT_TITLE: Accelerating Data and Metadata Standards in the Environmental Health Sciences Study of Emerging Water Contaminants


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Fentanyl Misuse and Addiction;Neurosciences;Opioid Misuse and Addiction;Opioids;Precision Medicine;Substance Misuse

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project Narrative New treatments are desperately needed for the persistent symptoms of opioid use disorder (OUD), including changes in mood, motivation, and cravings. This proposal is designed to improve our understanding of how discrete aspects of prefrontal cortex neural circuit function are related to behavioral changes following long- term fentanyl self-administration. Our goal is to develop translational metrics that will guide the development and utility of next-generation treatments for OUD.

PI_NAMEs: JOFFE, MAX E (contact)

PROGRAM_OFFICER_NAME: NAIR, SUNILA GOPI

PROJECT_TERMS: Abstinence;Address;Affect;affective disturbance;Area;Attenuated;Behavior;Behavioral;behavioral outcome;behavioral phenotyping;behavioral study;Biological Markers;Brain;Brain region;Calcium;Cannulas;Capsaicin;cell type;Cells;Chronic;Clinic;Clinical Research;Clozapine;combat;cost;craving;Data;design;Development;Disease;efficacious treatment;Electrodes;Electroencephalography;Electrophysiology (science);Elements;Equipment;Etiology;Exhibits;experience;Female;Fentanyl;fentanyl seeking;fentanyl self-administration;fentanyl use;Fiber;Fiber Optics;Foundations;Frequencies;Functional Magnetic Resonance Imaging;Gene Transfer;Genetic;Goals;Human Resources;Image;Implant;improved;Incubated;Individual;Individual Differences;individualized medicine;inhibitory neuron;innovation;Inpatients;Intake;inter-individual variation;Interneurons;Maintenance;maladaptive behavior;male;Maps;Mediating;Membrane;Modeling;Moods;Motivation;Mus;neural;neural circuit;Neurons;neurophysiology;neuroregulation;next generation;Operative Surgical Procedures;Opioid;opioid use;opioid use disorder;optogenetics;Outcome;Oxides;Parvalbumins;patch clamp;persistent symptom;personalized biomarkers;personalized medicine;Pharmaceutical Preparations;Phenotype;Photometry;Physiological;Physiology;Population;portability;Positron-Emission Tomography;Pre-Clinical Model;preclinical study;Prefrontal Cortex;Property;Pyramidal Cells;Recording of previous events;Refractory;Rehabilitation therapy;Relapse;Research Personnel;Resistance;Rest;Risk;Rodent;Rodent Model;Schedule;Self Administration;Signal Pathway;Signal Transduction;Slice;Somatostatin;Structure;Surface;Symptoms;Synapses;Testing;Training;transmission process;vapor;vector control;Viral

PROJECT_TITLE: Targeting PFC interneurons for personalized treatments in OUD

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


ED_INST_TYPE: SCHOOLS OF PHARMACY

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Faulty or dysregulated RNA levels have been linked to many human diseases such as cancer, neurodegeneration, and viral infections; yet drug discovery efforts targeting RNA molecules has proved challenging. In the cell, RNAs are often bound by RNA-binding proteins. Because dysregulation of these RNA- protein interactions has been implicated in many human diseases, in this project we describe our plans to expand the tools and technologies applicable to the study of RPIs to enable future drug discovery efforts for treating human disease.

PI_NAMEs: GARNER, AMANDA  (contact)

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TERMS: Affinity;Binding;Biochemical;Biological;Biological Assay;Biology;Cells;Cellular Assay;Cellular biology;cellular targeting;Chemicals;Code;Complement;Complex;Dependence;detection assay;Development;drug discovery;frontier;Future;human disease;inhibitor;insight;Laboratories;Link;Malignant Neoplasms;Mediating;Medicine;Natural Products;Nerve Degeneration;Nuclear Export;Peptides;Play;Proteins;Regulation;Research;RNA;RNA Binding;RNA Processing;RNA Recognition Motif;RNA-Binding Proteins;RNA-Protein Interaction;RNA-targeting therapy;screening;small molecule;Technology;tool;tool development;Transcript;Untranslated RNA;Validation;Virus Diseases;Work

PROJECT_TITLE: Chemical Biology Approaches for Investigating RNA-Protein Interactions

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


NIH_SPENDING_CATS: Genetics;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Embryonic - Non-Human

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: To develop properly, mammalian cells must express master regulatory genes only in the proper cell lineages. This requires that both repressive states and active states of these genes be ‘remembered’ throughout the lifetime of the organism, functions carried out by gene products from the Polycomb-Group and trithorax-Group. This application continues our longstanding characterization of the functional mechanisms of these complexes.

PI_NAMEs: KINGSTON, ROBERT  (contact)

PROGRAM_OFFICER_NAME: CHOW, CHI-WING

PROJECT_TERMS: Amino Acid Sequence;Animals;Behavior;Biological;Biological Process;Cell Lineage;Chemicals;Chromatin;Complex;conditional knockout;Core Protein;Development;Dimerization;Drosophila genus;embryonic stem cell;Epigenetic Process;experience;experimental study;Family;fly;gene product;Genes;Genetic Screening;Genetic Transcription;Genome;Histone H2A;Human;In Vitro;in vivo;knockout gene;Laboratories;Lysine;Maintenance;Mammalian Cell;Measures;member;Memory;mutant;Neurons;Nucleosomes;Organism;Organoids;paralogous gene;Pathway interactions;Pattern;Phase;Physical condensation;Play;Polycomb;PRC1 Protein;Property;Protein Region;Proteins;Protocols documentation;Regulator Genes;Repression;Research;Role;Specific qualifier value;stoichiometry;System;Testing;Time;tissue/cell culture;Total Internal Reflection Fluorescent;Vertebrates;Visualization

PROJECT_TITLE: Functional Analysis of Epigenetic Complexes

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

PHR: NARRATIVE Signal transduction, a process by which chemical and physical signals are transmitted through a cell, has a profound impact on human health and signal transduction pathways in bacteria and in humans are attractive targets for drug design. Understanding how signal transduction pathways function in bacterial and human cells is thus vital for our progress towards understanding and treating various diseases ranging from bacterial infections to cancer. We will use comparative genomics to better understand fundamental principles and molecular mechanisms of signal transduction in bacteria and elements of signal transduction in humans that are conserved throughout the Tree of Life.

PI_NAMEs: JOULINE, IGOR B. (contact)

PROGRAM_OFFICER_NAME: WANG, PEGGY

PROJECT_TERMS: Address;Bacteria;Bacterial Infections;Biological Process;Cells;Chemicals;Communities;comparative genomics;Databases;Disease;Drug Design;Drug Targeting;Elements;Genomics;Goals;Health;Human;innovation;Knowledge;Life;Ligands;Malignant Neoplasms;microbial;Modeling;Molecular;Organism;pathogenic bacteria;predictive modeling;Process;Property;public database;Research;Role;Signal Transduction;Signal Transduction Pathway;small molecule;System;tool;transmission process;Trees

PROJECT_TITLE: Computational Genomics of Signal Transduction

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

ORG_CITY: BLACKSBURG

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

ORG_STATE: VA

PHR: It is challenging to design drugs that target the proteins and nucleic acids that are central to many human diseases due to the complexity of their structures or their propensity to adopt many different structures. We seek to leverage cutting-edge simulation techniques to understand which states of amyloidogenic proteins and G- quadruplexes can be targeted and to design small molecules that will bind them. Outcomes of this work are important for new therapeutics against Alzheimer’s and Parkinson’s diseases, and many types of cancer.

PI_NAMEs: LEMKUL, JUSTIN ALAN (contact)

PROGRAM_OFFICER_NAME: GERSHENSON, ANNE

PROJECT_TERMS: Adopted;Affinity;Alzheimer's Disease;aqueous;Automobile Driving;base;Behavior;Binding;biophysical techniques;cancer type;Computer Assisted;design;Disease;Drug Design;Drug Targeting;electric field;Electronics;Free Energy;G-Quartets;Goals;human disease;insight;Investigation;Laboratories;Ligand Binding;Ligands;Malignant Neoplasms;Membrane;Methods;Modeling;Molecular;Molecular Conformation;molecular dynamics;monomer;novel therapeutics;Nucleic Acids;Outcome;Parkinson Disease;Peptides;Pharmaceutical Preparations;Phospholipids;programs;Proteins;Research;Role;Shapes;simulation;small molecule;small molecule therapeutics;Specificity;Structure;System;Techniques;Therapeutic;Validation;virtual screening;Virus Diseases;Vision;Work

PROJECT_TITLE: Exploring Electronic Polarization in Biomolecular Folding and Interactions

STUDY_SECTION: MRAE

STUDY_SECTION_NAME: Maximizing Investigators' Research Award - E Study Section[MRAE]


ADMINISTERING_IC: CK

IC_NAME: National Center for Emerging and Zoonotic Infectious Diseases

ORG_CITY: PONCE

ORG_NAME: PONCE SCHOOL OF MEDICINE

ORG_STATE: PR

PHR: PUBLIC HEALTH RELEVANCE  The public health significance of the proposed project is high given the considerable burden of disease due to dengue, the importance of other infectious agents, and the impending threat of arboviruses' introduction in Puerto Rico that include most recently, chikungunya and Zika. The current proposal also includes close collaboration with the Puerto Rico Vector Control Unit, which will allow a better understanding of the vector and local epidemiological conditions that impact dengue and arboviruses transmission. This study will enhance the understanding of the etiology, epidemiology, and severity of arboviral diseases, allowing the United States to be better prepared and respond to critical vector-borne disease outbreaks that can lead to devastating morbidity and mortality. Through a better understanding of these disease threats, and their control and prevention, morbidity and mortality may be decreased and global health security increased.

PI_NAMEs: RIVERA-AMILL, VANESSA  (contact)

PROJECT_TITLE: PUERTO RICO ENHANCED SURVEILLANCE AND CONTROL OF ARBOVIRUSES (PRESCA) PROGRAM


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Genetics;Human Genome;Neurosciences;Substance Misuse

ORG_CITY: WINSTON-SALEM

ORG_DEPT: NEUROSCIENCES

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

ORG_STATE: NC

PHR: NARRATIVE This study investigates the epigenetic mechanisms orchestrating the enduring alcohol-induced neuroadaptations of the brain following repeated cycles of abstinence/relapse. A combination of epigenetic, transcriptomic, pharmacological, gene editing and behavioral strategies will identify novel genes and pathways that hold promise as potential new therapeutic targets to curb alcohol abuse and prevent relapse.

PI_NAMEs: CERVERA JUANES, RITA P (contact)

PROGRAM_OFFICER_NAME: LORANG-LEINS, DOMINIQUE

PROJECT_TERMS: Abstinence;Advanced Development;Affect;Alcohol abuse;alcohol abuse therapy;Alcohol consumption;alcohol exposure;alcohol relapse;alcohol use disorder;Alcohol withdrawal syndrome;Alcoholic beverage heavy drinker;alcoholism therapy;Alcohols;Attention;Behavioral;bisulfite;Brain;brain tissue;Cause of Death;Chronic;chronic alcohol ingestion;Data;design;Development;differential expression;Disease remission;DNA Methylation;drinking;drinking behavior;Drug Metabolic Detoxication;effective therapy;Electrophysiology (science);Epigenetic Process;Ethanol;Exposure to;FDA approved;Female;gamma-Aminobutyric Acid;gene editing technology;Gene Expression;Gene Proteins;Gene Targeting;Genes;genetic manipulation;genome-wide;Glutamates;Goals;Heavy Drinking;Intoxication;Link;Macaca;male;Maps;Measures;Mediating;Modeling;Molecular;Mus;Nature;negative emotional state;neural circuit;neuroadaptation;neurotransmission;new therapeutic target;novel;Nucleus Accumbens;Outpatients;patch clamp;Pathway interactions;Persons;Pharmaceutical Preparations;pharmacologic;Pharmacology;Population;preference;preventable death;Primates;Progressive Disease;Proteins;Publishing;Relapse;relapse prevention;relapse risk;Reporting;Rodent;Rodent Model;Sampling;Self Administration;Sequence Analysis;sex;Signal Transduction;success;Support Groups;synaptic function;Synaptic plasticity;Testing;Time;Tissues;tool;Transcript;transcriptome sequencing;transcriptomics;Translations;transmission process;United States;Up-Regulation;Variant

PROJECT_TITLE: Identifying new targets for the treatment of alcohol dependence and relapse: epigenetic analysis of the abstinent brain

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: NORTHEASTERN UNIVERSITY

PHR: Project Narrative: Public Health Relevance: Monocytes and macrophages play major roles in many human diseases including infection, atherosclerosis, and cancer (tumor associated macrophages). In these different contexts, they have different polarizations that are incompletely understood. Here I propose experiments that can help us better understand their polarization and thus inform future therapeutic modalities.

PI_NAMEs: SLAVOV, NIKOLAI  (contact)

PROJECT_TERMS: aerobic glycolysis;Algorithms;Atherosclerosis;Automobile Driving;Biomedical Research;Cells;Data;Data Analyses;Environment;experimental study;Future;Genetic;Genetic Transcription;Goals;Human;human disease;Immune response;Infection;Macrophage;Macrophage Activation;Maintenance;Malignant Neoplasms;Masks;Measurement;Mediating;Metabolic;Metabolism;Methods;Modality;Molecular;monocyte;pathogen;Pattern;pharmacologic;Physiological;Play;Population;Population Analysis;Positioning Attribute;Process;Property;Proteins;public health relevance;Research;Resolution;response;Role;Shapes;Signal Transduction;single cell analysis;System;Testing;Therapeutic;tissue regeneration;transcriptomics;Tumor-associated macrophages;Variant

PROJECT_TITLE: Molecular and metabolic influences on the activation of monocytes and macrophages at single-cell resolution


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cardiovascular;Heart Disease;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Transplantation

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative Ischemic cardiovascular diseases are the leading cause of morbidity and mortality in the USA; however, clinical therapies that can grow blood vessels in the ischemic organs are currently lacking. Over the years, we have generated both endothelial cells and smooth muscle cells, which are essential components of the vessels, from human pluripotent stem cells (hPSCs) and have developed a novel composite biomaterial to enhance transplanted cell survival. In this proposal, we will determine the neovascularization and therapeutic effects of a combination of hPSC-derived endothelial cells and smooth muscle cells encapsulated in a new injectable biomaterial on tissue ischemia models.

PI_NAMEs: YOON, YOUNG-SUP  (contact)

PROGRAM_OFFICER_NAME: LUNDBERG, MARTHA

PROJECT_TERMS: adult stem cell;Alginates;American;Area;arteriole;Biocompatible Materials;Biological;Biomedical Engineering;Blood capillaries;blood vessel development;Blood Vessels;Cardiac Myocytes;Cardiovascular Diseases;Cell Culture System;Cell Differentiation process;Cell Lineage;Cell Physiology;Cell Survival;Cell Therapy;Cell Transplantation;cell type;Cells;Clinical;clinical application;Clinical Trials;copolymer;Dependence;design;Disease;disease prognosis;Effectiveness;Encapsulated;Endothelial Cells;Engineering;expectation;Functional disorder;Gel;Gelatin;Generations;Goals;Hindlimb;Histologic;Human;human embryonic stem cell;human induced pluripotent stem cells;human pluripotent stem cell;Hybrids;Hydrogels;Impairment;improved;in vivo;induced pluripotent stem cell;Inflammatory Response;Injectable;Injections;Intervention;Ischemia;Magnetic Resonance Imaging;Measurement;Methacrylates;microCT;Microspheres;Modeling;Molecular;Morbidity - disease rate;mortality;Mus;Myocardial Ischemia;nano;neovascularization;next generation;novel;Operative Surgical Procedures;Organ;Outcome;paracrine;Patients;peptide amphiphiles;Pericytes;Peripheral arterial disease;poly(glycerol-sebacate);Polymers;Population;preclinical study;Protocols documentation;regenerative therapy;Research;Research Personnel;revascularization;Smooth Muscle Myocytes;stem cells;System;Technology;Therapeutic;Therapeutic Effect;Tissues;Vascular Diseases;Vascular regeneration;Vascularization;virtual;Virus

PROJECT_TITLE: Vascular Regeneration with Human Pluripotent Stem Cell-derived Vascular Cells and Engineering Approaches

STUDY_SECTION: IVPP

STUDY_SECTION_NAME: Integrative Vascular Physiology and Pathology Study Section[IVPP]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Liver Disease;Substance Misuse

PHR: Alcohol-related liver disease (ALD) is a prevalent clinical problem, with many knowledge gaps in the pathogenesis of ALD, including the role and regulation of inflammatory and tissue reactions. The extracellular matrix (ECM) is known to be important in ALD, is produced by resident cells in the tissue/organ and contains diverse components, including newly-described matrix-bound nanovesicles (MBV) that contain biologically active signaling molecules known to regulate and affect normal and diseased tissues. We hypothesize that MBV are important in regulating ALD pathogenesis and disease progression, and in this grant we will identify key changes in liver MBV during ALD/fibrosis, understand mechanisms of liver MBV effects in ALD, and test the ability of MBV to treat experimental ALD.

PI_NAMEs: ARTEEL, GAVIN E;SCOTT, MELANIE J. (contact)

PROGRAM_OFFICER_NAME: WANG, JOE

PROJECT_TERMS: acute liver injury;Affect;alcohol exposure;Alcoholic Hepatitis;Alcoholic Liver Diseases;Alcohols;Binding;Biodistribution;Biology;Biotin;Calpain;cell behavior;Cell Death;cell injury;Cell Proliferation;cell regeneration;cell type;Cells;Cirrhosis;Clinical;Data;Development;Disease;Disease Marker;Disease Progression;Dose;endoplasmic reticulum stress;experimental study;Exposure to;Extracellular Matrix;Extracellular Matrix Degradation;Fibrosis;Goals;Grant;Hepatic;Hepatocyte;hepatoprotective;Homeostasis;Human;human disease;immunoregulation;in vivo;Inflammation;Inflammatory;Inflammatory Response;Intervention;Knowledge;Label;Liver;Liver diseases;Liver Fibrosis;liver inflammation;liver injury;Liver Regeneration;Macrophage;Maintenance;Mediating;Messenger RNA;MicroRNAs;microvesicles;Mitochondria;mouse model;Mus;nanoscale;nanovesicle;novel;Organ;Pathogenesis;Patients;Peptide Hydrolases;Phenotype;Play;pre-clinical;Process;Production;Proteins;Proteome;Proteomics;Reaction;Regulation;response;response to injury;RNA;Role;Signal Transduction;Signaling Molecule;Source;stem cell differentiation;targeted treatment;Testing;Therapeutic;Therapeutic Effect;Therapeutic Uses;tissue biomarkers;Tissues;Translating;Translations;Vesicle;vesicular release;Work

PROJECT_TITLE: The role of matrix-bound microvesicles in alcohol-related liver disease

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Digestive Diseases;Genetics;Pancreatic Cancer;Rare Diseases

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: PROJECT NARRATIVE Metabolic pathways support cancer cell proliferation, but whether common cancer-associated metabolic alterations drive epigenetic changes that contribute to malignant progression remains poorly understood. We propose to investigate the hypothesis that metabolic control of the chromatin landscape is a major mechanism of p53-mediated tumor suppression in pancreatic cancer. These studies will provide fundamental insight into how metabolic reprogramming driven by the most commonly mutated gene in human cancer contributes to tumor progression and suggest metabolism-targeted strategies to activate tumor suppressive pathways in malignant cells.

PI_NAMEs: FINLEY, LYDIA  (contact)

PROGRAM_OFFICER_NAME: WILLIS, KRISTINE AMALEE

PROJECT_TERMS: Address;Affect;alpha ketoglutarate;Binding;cancer cell;cancer initiation;Cell Differentiation process;Cell Proliferation;Cell Survival;Chemicals;Chromatin;Citric Acid Cycle;Consumption;Data;Deposition;Dioxygenases;DNA;DNA Modification Process;Down-Regulation;enzyme substrate;Enzymes;Epigenetic Process;experimental study;Family;Gene Expression;Gene Expression Profile;Gene Expression Profiling;Genes;genetic manipulation;Genetic Transcription;glucose metabolism;Goals;Growth;histone modification;Histones;Human;inhibitor;insight;KRAS oncogenesis;KRAS2 gene;Maintenance;Malignant - descriptor;Malignant neoplasm of pancreas;Malignant Neoplasms;malignant phenotype;malignant state;Maps;Measures;Mediating;Metabolic;Metabolic Control;Metabolic Pathway;Metabolism;Modification;Molecular;mouse model;mutant;Mutate;Mutation;neoplastic cell;novel;Oncogenes;Oncogenic;Output;Oxidases;pancreatic cancer cells;pancreatic cancer model;pancreatic tumorigenesis;Pathologic;Pathway interactions;Phenocopy;Precancerous Conditions;premalignant;programs;Proliferating;Regulation;response;Stress;Succinates;Testing;TP53 gene;tumor;tumor progression;Tumor Suppression;Tumor Suppressor Proteins;tumorigenesis;Work

PROJECT_TITLE: Regulation of tumor suppression by alpha-ketoglutarate

STUDY_SECTION: TCB

STUDY_SECTION_NAME: Tumor Cell Biology Study Section[TCB]


NIH_SPENDING_CATS: Cancer;Patient Safety

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: The Chesapeake-Ohio Pharmacokinetics Core (ChOP-KC) will continue its long-standing contribution to the drug development efforts of the NCI through the Experimental Therapeutics Clinical Trials Network (ETCTN). We will apply clinical pharmacology principles to characterize relationships between drug exposure and clinical outcomes to aid in determining the optimal drug dose and schedule in current and future cancer clinical trials.

PI_NAMEs: BEUMER, JAN HENDRIK (contact);PHELPS, MITCH A

PROGRAM_OFFICER_NAME: HENDERSON, LORI A

PROJECT_TERMS: Acceleration;Adult;AIDS Malignancy Consortium;Analytical Chemistry;analytical method;Antineoplastic Agents;appropriate dose;assay development;Beds;Biological;Brain Neoplasms;cancer clinical trial;Cancer Patient;cancer therapy;career;Clinical;clinical care;Clinical Drug Development;Clinical Investigator;Clinical Pharmacology;Clinical Protocols;clinical trial protocol;Clinical Trials;Clinical Trials Design;Clinical Trials Network;Collaborations;Conduct Clinical Trials;Data;Data Analyses;Decision Making;demographics;design;Development;Dose;drug development;Drug Exposure;Drug Interactions;Drug Kinetics;early phase clinical trial;Ensure;Environment;Evaluation;experience;Foundations;Funding;Future;Generations;Genetic;Genetic Polymorphism;Goals;good laboratory practice;Individual;Infrastructure;Institution;Investigational Therapies;investigator-initiated trial;Liquid substance;Malignant Neoplasms;Maryland;Mediating;method development;novel;Ohio;Outcome;Pharmaceutical Preparations;Pharmacodynamics;Pharmacology;Pharmacology Study;pharmacometrics;protocol development;Recommendation;Reporting;Research Design;Resource Sharing;Risk;sample collection;Sampling;Schedule;Services;Solid;Source;Specific qualifier value;Specimen;Testing;therapeutic development;Toxic effect;translational medicine;translational study;trial design;U-Series Cooperative Agreements;Universities;Validation;Variant

PROJECT_TITLE: The Chesapeake-Ohio Pharmacokinetics Core for The ETCTN


NIH_SPENDING_CATS: Diabetes

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Diabetes affects 30 million people in the US, and another 50-80 million have metabolic syndrome or pre-diabetes, indicating that 1/3 of the US population has, or is at risk of getting, diabetes. Inadequate numbers of insulin- producing pancreatic beta cells underlie all forms of diabetes, an observation that has focused NIH efforts on developing drugs that will enable replacement or regeneration of human beta cells for people with diabetes. This application describes our progress to date in the development of human beta cell regenerative drugs, and our plans for further advancing this process to translational stages.

PI_NAMEs: DEVITA, ROBERT J;GARCIA-OCANA, ADOLFO ;STEWART, ANDREW F. (contact)

PROGRAM_OFFICER_NAME: HWA, ALBERT J

PROJECT_TERMS: Adult;Affect;Agonist;Animal Model;Automobile Driving;Beta Cell;Binding;Cell Differentiation process;Cell Physiology;Cell Proliferation;cell regeneration;chemical synthesis;Chemicals;Data;design;Development;Diabetes Mellitus;diabetic;euglycemia;exenatide;Family;GCG gene;Goals;Grant;Harmine;Human;In Vitro;in vivo;inhibitor;Insulin;Insulin-Dependent Diabetes Mellitus;Islets of Langerhans Transplantation;Learning;Legal patent;Ligands;Location;Medicine;Metabolic syndrome;Modeling;Mus;National Institute of Diabetes and Digestive and Kidney Diseases;Natural regeneration;next generation;Non-Insulin-Dependent Diabetes Mellitus;novel;Persons;Pharmaceutical Chemistry;Pharmaceutical Preparations;Phosphotransferases;Population;pre-clinical;Pre-Clinical Model;preclinical toxicity;Prediabetes syndrome;Process;Proliferating;prototype;receptor;regenerative cell;Reproducibility;Risk;Running;S-Phase Fraction;Safety;Signal Pathway;small molecule;Structure of beta Cell of islet;Structure-Activity Relationship;targeted delivery;Therapeutic;Transforming Growth Factor beta;Translating;Transplantation;type I and type II diabetes;United States National Institutes of Health;Vertebral column;Work

PROJECT_TITLE: DYRK Inhibitors for Human Beta Cell Expansion

STUDY_SECTION: BMDM

STUDY_SECTION_NAME: Basic Mechanisms of Diabetes and Metabolism Study Section[BMDM]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Clinical Research;Data Science;Digestive Diseases;Infectious Diseases;Pediatric;Precision Medicine

PHR: Project Narrative Diarrheal infections are a top cause of death and illness in young children worldwide. We propose to use new epidemiological and big data methods to identify data sources, including biomarkers, that could help with the clinical management of children with diarrhea. Through these projects, we will build the capacity of Dr. Leung to mentor patient-oriented researchers in pediatric diarrhea.

PI_NAMEs: LEUNG, DANIEL TED (contact)

PROGRAM_OFFICER_NAME: GLOCK, JONATHAN A

PROJECT_TERMS: Address;Advanced Development;Antibiotics;antimicrobial;Area;Award;Bangladesh;Big Data Methods;Bioinformatics;Biological Markers;biomarker discovery;biomarker identification;Biometry;candidate identification;candidate marker;care seeking;Cause of Death;Cessation of life;Child;Childhood;Cholera;Clinical;clinical care;clinical decision support;clinical decision-making;Clinical Management;clinical predictive model;clinical predictors;cohort;Collaborations;Communicable Diseases;Complement;cost;Country;Data;Data Science;Data Sources;Detection;Diagnosis;Diagnostic;diagnostic panel;Diagnostic tests;Diarrhea;diarrheal disease;Enrollment;enteric infection;epidemiologic data;Epidemiology;Etiology;experience;Foundations;Frequencies;Funding;Future;Goals;Immunology;improved;Income;Individual;Infection;Infrastructure;Knowledge;low and middle-income countries;Mentors;Mentorship;metabolomics;Methods;microbial;Microbiology;molecular diagnostics;Morbidity - disease rate;pathogen;Pathogen detection;patient oriented;patient oriented research;Physicians;Planet Earth;point of care;Population;predictive tools;Probability;Prognosis;programs;Public Health;Qualitative Methods;remote sensing;Research;Research Design;Research Personnel;Resource-limited setting;Role;Scientist;Serology;serosurveillance;spatial integration;Statistical Methods;statistics;support tools;Testing;Time;tool;Training;transcriptomics;Triage;United States National Institutes of Health;Universities;Utah;Viral;Work

PROJECT_TITLE: Mentoring patient-oriented researchers in pediatric diarrhea

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases Advisory Committee[MID]


NIH_SPENDING_CATS: Aging;Physical Injury - Accidents and Adverse Effects;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE Skeletal muscle mitochondrial dysfunction has been associated with the development of muscle atrophy and its comorbidities. Understanding the key regulators in skeletal muscle that contribute to the development of muscle atrophy are critical to improving clinical outcomes. The purpose of this study is to determine whether FGF-21 acts in an autocrine manner on skeletal muscle to inducing muscle atrophy.

PI_NAMEs: ROWE, GLENN CAMERON (contact)

PROGRAM_OFFICER_NAME: BOYCE, AMANDA T

PROJECT_TERMS: Ablation;Acute;Address;Adult;Animals;antagonist;Atrophic;Attenuated;autocrine;Bed rest;Biochemical;Biological;Body Composition;Cell Physiology;Chimeric Proteins;Chronic;Circulation;Clinical;comorbidity;Contusions;Data;Diabetes Mellitus;Disease;Effectiveness;Exercise;exercise capacity;Exhibits;Fibroblast Growth Factor;fibroblast growth factor 21;Genes;Genetic;Genetic Models;Goals;Homeostasis;Impairment;improved;Inpatients;insight;Intervention;Lead;Link;Messenger RNA;Metabolism;Mitochondria;mitochondrial dysfunction;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;mRNA Expression;Mus;Muscle;Muscle Development;muscle form;Muscle function;Muscle Mitochondria;Muscular Atrophy;new therapeutic target;novel;Obesity;Outcome;Outer Mitochondrial Membrane;overexpression;Oxidative Stress;Pathogenesis;Pathologic;Pathology;Patients;Performance;pharmacologic;Pharmacologic Substance;Physiological;Physiology;Predisposition;preservation;prevent;Protein Biosynthesis;Proteins;Publishing;Quality Control;Quality of life;receptor;Recovery of Function;reduced muscle mass;Reporting;Research;response;Signal Transduction;skeletal circulation;Skeletal Development;Skeletal Muscle;skeletal muscle wasting;skeletal preservation;Spinal Cord Contusions;Spinal cord injury;Stress;Surgical Models;Testing;Therapeutic Intervention

PROJECT_TITLE: Autocrine Action of Elevated FGF-21 Contributing to Skeletal Muscle Atrophy in Response to Mitochondrial Dysfunction

STUDY_SECTION: SMEP

STUDY_SECTION_NAME: Skeletal Muscle and Exercise Physiology Study Section[SMEP]


ORG_CITY: HOGANSBURG

ORG_NAME: SAINT REGIS MOHAWK TRIBE

ORG_STATE: NY

PHR: Project Narrative. The Akwesasne Research Center for Health (ARCH) project proposed by the St. Regis Mohawk Tribe (SRMT) will continue building on strengths for SRMT health research; identify cancer health implications as a result of local air and water quality; provide effective data on novel health promotion interventions and assessment towards advancing the fields of community health through sustainable workplace initiatives for obesity and liver disease prevention; and create new opportunities for SRMT youth to explore and better understand public health, health research, and cancer sciences. Collectively, these projects will support SRMT's strategic goals to build local health research capacity and implement data-driven decision making for the community that positively impacts health and wellness. The ARCH project contributes to SRMT's commitment to use their Indigenous Knowledge to prevent, address, and study illness today to help benefit generations to come.

PI_NAMEs: COOK, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: RICHARDS, CRYSTAL LYNETTE

PROJECT_TERMS: Address;Agreement;Air;Akwesasne;Alaska Native;Aluminum;American Indians;anti-cancer research;Area;Behavior;cancer health disparity;cancer prevention;Cancer Science;career awareness;Career Choice;Chemicals;Collaborations;Communities;community engagement;Community Health;Comprehensive Cancer Center;Consultations;Data;Data Collection;Decision Making;design;Development;Diet;disorder prevention;disparity reduction;Education;effectiveness evaluation;Ensure;Environment;Environmental Health;Epidemiology;Equipment;Evaluation;evidence base;experience;Generations;Goals;Government Officials;Health;Health behavior;Health Promotion;Health Promotion and Education;health science research;Health Sciences;Healthcare Systems;high school;Human;Human Resources;Indigenous;interest;Intervention;Knowledge;Learning;Life;Life Style Modification;Liver;Liver diseases;Malignant Neoplasms;Measures;meetings;member;Metals;Methods;Mohawk Tribe;novel;Obesity;Outcome;Paper;Pathway interactions;Persons;Physical activity;Polychlorinated Biphenyls;prevent;Principal Investigator;Productivity;programs;Public Health;Quality of life;Research;Research Personnel;Research Project Grants;Research Support;Scholars Program;school health;Schools;Science;Scientist;screening;Services;skills;Statistical Data Interpretation;Stress;stress resilience;Student recruitment;Students;summer program;summer research;symposium;Telephone;Testing;timeline;Training;tribal community;tribal health;tribal Nation;Tribes;United States Indian Health Service;university student;virtual;virtual intervention;Vision;Water;water quality;webinar;Work;Workplace;Youth

PROJECT_TITLE: Akwesasne Center for Health Research Project FY20

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-Y(55)]


NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research

PI_NAMEs: HARING, RODNEY C (contact)

PROJECT_TERMS: Adherence;Akwesasne;anti-cancer research;Area;Behavioral Sciences;Biology;Communication;Communities;community based research;Complex;cultural values;Data;data integrity;Dissemination and Implementation;Ecosystem;Elements;Ethics;Evaluation;flexibility;Health;Indigenous;indigenous community;Individual;Institutional Review Boards;interdisciplinary approach;International;intertribal;Leadership;Life;Life Style;Liver;Medicine;member;Methodology;Modeling;Mohawk Tribe;multidisciplinary;Outcome;physical science;Policies;population health;Process;Program Evaluation;programs;Protocols documentation;Quality Control;Reporting;Research;Research Ethics;Research Personnel;Research Project Grants;Resources;Schools;Science;Social Sciences;Societies;stem;Students;System;Systems Theory;timeline;tribal organization;Tribes;United States Indian Health Service;United States National Institutes of Health;Update;virtual

PROJECT_TITLE: Akwesasne Center for Health Research

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-Y]


NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: HERSHBERGER, RICHARD PAUL (contact)

PROJECT_TERMS: academic preparation;Address;Advocacy;Akwesasne;anti-cancer research;Awareness;Bachelor's Degree;behavioral health;Biological;Cancer Biology;Cancer Burden;cancer epidemiology;cancer health disparity;Cancer Science;career;Case Study;Clinical Trials;Collection;college;College Preparation;Communities;community based research;community engagement;Complement;Comprehensive Cancer Center;Data Analyses;Data Collection;Degree Completion;Development;Dropout;Education;Educational workshop;Effectiveness;Enrollment;Environment;Environmental Health;Epidemiology;experience;Faculty;Family;Family member;Feeling;Goals;Graduate Education;graduate school;graduate school preparation;Health;Health behavior;health care disparity;health disparity;Health Professional;Health Sciences;Healthcare;high school;High School Student;Indigenous;indigenous community;Instruction;interest;Knowledge;Laboratory Research;Learning;lectures;literacy;Low income;Malignant Neoplasms;medical schools;member;Mentorship;Methods;minority student;Mission;Mohawk Tribe;Native American Research Center for Health;Native Americans;Outcome;peer;Play;Population Sciences;Prevention;programs;Public Health;public health research;Research;research faculty;Research Personnel;Research Project Grants;Role;Rural Community;Saints;Sampling;Scholars Program;school health;Schools;Science;science teacher;Scientist;screening;Self Efficacy;Series;skills;social;Statistical Data Interpretation;statistics;student participation;Students;success;summer research;Surveys;symposium;Tablets;Time;Training;tribal college;tribal community;Underrepresented Minority;underrepresented minority student;university student;Youth

PROJECT_TITLE: Saint Regis Mohawk Research Scholars Program


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Dissemination and Implementation Research;Drug Abuse (NIDA only);Health Services;Mental Health;Substance Misuse

ORG_CITY: SAINT LOUIS

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative The IRI uniquely trains for mental health implementation science, a field essential to attaining objectives in NIMH’s Strategic Plan. Training new IRI Core Faculty members will boost the field’s leadership capacity. Evaluation products will demonstrate translational benefits of implementation science. Fellows’ research will accelerate innovation in implementation science and inform sustainable improvements to mental health care – thereby reducing the burden of mental illness for countless individuals and families.

PI_NAMEs: PROCTOR, ENOLA K (contact)

PROGRAM_OFFICER_NAME: SIMS, BELINDA ENITA

PROJECT_TERMS: Acceleration;Adoption;Affect;American;Bibliometrics;career;Caring;Case Study;cohort;Collaborations;Communities;Competence;Creativeness;education research;Effectiveness;empowerment;Evaluation;evidence base;Evidence based intervention;Faculty;faculty mentor;Family;Fostering;Funding;Future;Generations;Goals;Health Services Research;Home;implementation outcomes;implementation research;implementation science;improved;Individual;innovation;Institution;Investments;Knowledge;Lead;Leadership;leadership development;Learning;Maps;member;Mental disorders;Mental Health;Mental Health Services;mental training;Mentors;Methods;Modeling;National Institute of Drug Abuse;National Institute of Mental Health;next generation;Outcome;Pathway Analysis;Pathway interactions;peer;Positioning Attribute;Principal Investigator;Public Health;Reporting;Research;Research Institute;Research Personnel;Research Training;response;Role;scale up;Science;Scientific Advances and Accomplishments;Seasons;Site;skill acquisition;skills;Social Network;Strategic Planning;summer institute;Training;Training Programs;Translational Research;Translations;Travel;United States Department of Veterans Affairs;United States National Institutes of Health

PROJECT_TITLE: Implementation Research Institute for Mental Health Services IRI-MHS


NIH_SPENDING_CATS: Aging;Osteoporosis;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Women's Health Research

ORG_CITY: INDIANAPOLIS

ORG_DEPT: ORTHOPEDICS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: NARRATIVE This proposal will substantially increase understanding of the mechanisms that regulate PKA signaling and age-related bone loss. This proposal will also determine whether PKIis an exciting potential therapeutic target, either alone or in combination with iPTH, for age-related bone loss, the age-related decline in fracture healing, and/or post-menopausal bone loss. Such results would lead to more translational Future Directions targeting PKI (Section 3.4).

PI_NAMEs: GREENFIELD, EDWARD M. (contact)

PROGRAM_OFFICER_NAME: WILLIAMS, JOHN

PROJECT_TERMS: Acceleration;Adult;Adult women;Affect;Age;age related;age related decline;Age-Related Bone Loss;Apoptosis;bone;bone fracture repair;bone loss;Bone Resorption;Cyclic AMP;Cyclic AMP-Dependent Protein Kinases;Elderly man;Elderly woman;Enterobacteria phage P1 Cre recombinase;Equilibrium;Family member;FDA approved;Female;Forteo;Fracture;Future;Genetic;Goals;healing;Homeostasis;In Vitro;in vivo;Injections;knock-down;lipid biosynthesis;LoxP-flanked allele;Mediating;men;Mus;old mice;Osteoblasts;Osteocalcin;Osteogenesis;Osteoporosis;osteoprogenitor cell;Ovariectomy;Patients;Persons;Pharmaceutical Preparations;Postmenopausal Osteoporosis;Postmenopause;Process;progenitor;Proliferating;promoter;protein kinase inhibitor;PTH gene;Regulation;response;Role;senescence;sex;Signal Transduction;Site;skeletal;spine bone structure;substantia spongiosa;Testing;therapeutic target;Tissues;Woman;young adult

PROJECT_TITLE: Regulation of age-related bone loss by PKIgamma


ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE Cryptococcus neoformans is the most common cause of fungal meningitis and among the most important fungal pathogens, accounting for approximately 20% worldwide deaths from HIV/AIDS. This study will generate unique genomic resources including a whole-genome tagged strain collection and a genetic interaction map. These resources will enable the research community to develop a comprehensive understanding of how this pathogen causes disease and responds to drugs thereby laying a new foundation for combatting invasive fungal infections.

PI_NAMEs: MADHANI, HITEN D (contact)

PROGRAM_OFFICER_NAME: LOVE, DONA

PROJECT_TERMS: Acceleration;Accounting;Animal Disease Models;Animals;Biochemical;Biological;C-terminal;Cells;Cessation of life;Clinical;Code;Codon Nucleotides;Collection;Communities;Coupled;CRISPR screen;CRISPR/Cas technology;Cryptococcus;Cryptococcus neoformans;Data;Data Analyses;Databases;Defect;deletion library;Deposition;design;design and construction;Diagnosis;Disease;DNA;Electroporation;Encapsulated;fitness;Foundations;fungal genetics;Fungal Meningitis;Gene Cluster;Gene Deletion;gene gun;Gene Structure;Generations;Genes;Genetic;Genome;genome resource;genome-wide;Genomics;Growth;Haploidy;HIV/AIDS;homologous recombination;Human;Image;In Vitro;Investigation;Knock-out;knockout gene;Laboratories;Letters;Libraries;machine learning method;Maps;Medical;member;Methodology;Methods;Microscopy;Modification;Mus;Mutagens;mutant;Mycoses;next generation sequencing;novel;novel strategies;Oligonucleotides;Online Systems;Open Reading Frames;pathogen;pathogenic fungus;Pathway interactions;Pharmaceutical Preparations;Positioning Attribute;Production;Proteins;Publications;Quality Control;Research;Resources;Saccharomyces cerevisiae;Saccharomycetales;screening;Site;The science of Mycology;therapy development;tool;Update;Virulence;web-accessible;web-based informatics;whole genome;Work;Yeast Model System

PROJECT_TITLE: Cryptococcus genomic resources

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIA-H(02)]


NIH_SPENDING_CATS: Cancer;Hematology

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: Project Narrative The NU-TRIHO Training Program is designed to train academically oriented Medicine and Pediatric Hematology- Oncology fellows at Northwestern University to become successful translational researchers. It integrates an educational curriculum and a career development program with laboratory and clinical research training to prepare trainees for careers in academic medicine. A group of highly qualified laboratory and clinical preceptors will provide guidance and mentorship to the trainees in the NU-TRIHO Training Program.

PI_NAMEs: HUSSAIN, MAHA H;MUNSHI, HIDAYATULLAH G. (contact)

PROGRAM_OFFICER_NAME: LIM, SUSAN E

PROJECT_TITLE: NU-TRIHO (Northwestern University Translational Research in Hematology-Oncology) Training Program

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


NIH_SPENDING_CATS: Bioengineering;Biotechnology

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Kinase inhibitor drugs have changed the face of therapeutics and are projected to remain a major focus of drug development, however, their long-term efficacy is variable because of biological complexity and resistance. We are developing assay strategies that can be used to study kinase signaling biology, and screen new drugs and drug combinations in a way that better mimics biological complexity. These could someday also be used as companion diagnostics for the drugs they help discover, to monitor the effectiveness of treatment, finding resistance earlier so patients can try alternatives that could improve their treatment outcomes.

PI_NAMEs: PARKER, LAURIE L. (contact)

PROGRAM_OFFICER_NAME: BARNES, CHARLES ASHLEY

PROJECT_TERMS: Acetylesterase;Acidic Amino Acids;assay development;Autoimmune Diseases;base;Basic Science;Biochemical;Biological;Biological Assay;Biological Models;Biology;Cells;chelation;Clinic;Clinical;Clinical Chemistry;Collaborations;companion diagnostics;Complex;Data;design;Detection;Development;Disease;Drug Combinations;drug development;drug discovery;Drug Targeting;Enzymes;experimental study;Face;flexibility;Fluorescence;Future;genomic biomarker;Goals;Heart Diseases;high throughput analysis;high throughput screening;improved;in silico;In Vitro;inhibitor therapy;instrumentation;ionization;kinase inhibitor;Lanthanoid Series Elements;Malignant Neoplasms;Mass Spectrum Analysis;Measurement;Measures;Methods;Methyltransferase;Mixed Function Oxygenases;Monitor;Mutation;novel;novel therapeutics;overexpression;Patients;Peptides;Performance;Pharmaceutical Preparations;Phosphopeptides;phosphoproteomics;Phosphotransferases;Post-Translational Protein Processing;prediction algorithm;preference;Process;protein biomarkers;Protein Tyrosine Kinase;Proteomics;Protocols documentation;prototype;Publishing;Ramp;Reaction;Reporting;Resistance;Running;Sampling;screening;Signal Transduction;Techniques;Technology;Testing;Therapeutic;Time;tool;Translations;Treatment Effectiveness;Treatment outcome;Work

PROJECT_TITLE: Multiplexed proteomics-based kinase assay development

STUDY_SECTION: EBIT

STUDY_SECTION_NAME: Enabling Bioanalytical and Imaging Technologies Study Section[EBIT]


ADMINISTERING_IC: NS

ED_INST_TYPE: UNIVERSITY-WIDE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: PHILADELPHIA

ORG_NAME: DREXEL UNIVERSITY

PHR: PROJECT NARRATIVE: The proposed research is relevant to public health because understanding the mechanisms by which the spinal cord circuitry selectively activates motoneurons to produce a motor response underpins a significant fraction of motor control, and dysfunctions in the motor system can greatly reduce quality of life. Thus, this proposal is relevant to the part of NIH’s mission for promoting innovative and creative research strategies for applications to protecting and improving health.

PI_NAMEs: SMITH, TREVOR SHAWN (contact)

PROGRAM_OFFICER_NAME: MATTHEWS, MARGUERITE

PROJECT_TERMS: analog;Anatomy;Animals;Biology;Biomedical Engineering;career;Cells;Chronic;Clinical;clinical application;Complex;Conscious;Creativeness;density;Disease;Electric Stimulation;Electrodes;Electromyography;Elements;Engineering;Exhibits;extracellular;flexibility;Freedom;Functional disorder;Generations;Goals;Health;Hindlimb;Human;improved;Individual;innovation;insertion/deletion mutation;Interneurons;intraspinal microstimulation;Intuition;Investigation;Joints;Lampreys;Limb structure;Linear Models;Locomotion;Mathematics;Mediating;Methods;Mission;Modeling;Modification;Motor;Motor Activity;motor behavior;motor control;motor disorder;Motor Neurons;Movement;Mus;Muscle;neural correlate;Neurobiology;Neuromodulator;Neurons;neuroprosthesis;Neurosciences;Neurotransmitters;new technology;nonhuman primate;novel;Outcome;Pattern;Pattern Formation;Periodicity;pharmacologic;Phase;Physiology;Population;Process;programs;Property;Public Health;Quality of life;Rana;Rana catesbeiana;recruit;Reflex action;Research;response;restoration;Scientist;Signal Transduction;Site;skills;Spinal;Spinal Cord;Spinal cord injury;Spinal Manipulation;spinal reflex;Stereotyping;Structure;synergism;System;Techniques;Testing;Tetrapoda;Time;tool;Training;translational applications;Turtles;United States National Institutes of Health;Universities;Vertebrates;Wheelchairs;Work

PROJECT_TITLE: Independence of Spinal Motor Modules and Motoneuron Recruitment from Motor Modules: New Experimental Tests


NIH_SPENDING_CATS: Brain Disorders;Cannabinoid Research;Infectious Diseases;Neurodegenerative;Neurosciences;Therapeutic Cannabinoid Research

ORG_CITY: SAN JUAN

ORG_NAME: UNIVERSITY OF PUERTO RICO MED SCIENCES

PHR: Project Narrative Cathepsin B is a lysosomal protease that plays a significant role in the neurotoxicity caused by HIV-infected macrophages, which are the main reservoirs of HIV in the brain. Cannabinoid receptor type 2 (CB2R) activation by agonists decrease cathepsin B secretion, neurotoxicity, HIV-1 replication, and inflammation in macrophages. Therefore, understanding the mechanisms of CB2R activation in macrophages and cathepsin B neurotoxicity will permit the development of alternative strategies against HIV-associated neurocognitive disorders (HAND).

PI_NAMEs: ROSARIO-RODRÍGUEZ, LESTER JOSÉ (contact)

PROGRAM_OFFICER_NAME: DALEY, WILLIAM PATRICK

PROJECT_TERMS: Academia;Adenylate Cyclase;Affect;Agonist;Agreement;antiretroviral therapy;Attenuated;Autopsy;blood-brain barrier permeabilization;Brain;brain tissue;Cathepsins B;Cell Reprogramming;Cells;Chronic;CNR2 gene;Confocal Microscopy;cytokine;Development;effective therapy;Enzymes;Flow Cytometry;Future;HIV;HIV Infections;HIV Seropositivity;HIV-1;HIV-associated neurocognitive disorder;Human;Immunohistochemistry;Immunoprecipitation;In Vitro;Individual;Induced Neurons;Infection;Infiltration;Inflammation;Inflammatory;Inositol;Knowledge;Label;Laboratories;Learning;life span;Macrophage;MAPK3 gene;Mentors;Microglia;monocyte;Neurodegenerative Disorders;neuron apoptosis;Neurosciences;neurotoxic;neurotoxicity;Nicotinic Receptors;novel therapeutics;Organoids;Pathway interactions;Patients;Peptide Hydrolases;Persons;Phase;Phospholipase C;Play;Postdoctoral Fellow;prevent;Proteins;Proteomics;receptor;Research;Research Personnel;Research Project Grants;Role;Serum Amyloid P-Component;Signal Transduction;tandem mass spectrometry;Techniques;Testing;therapy development;Training;treatment strategy;tripolyphosphate;Validation;Viral Proteins;Western Blotting;Work

PROJECT_TITLE: Modulation of alpha-7 nicotinic acetylcholine receptor in HIV-infected microglia and brain organoids


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: Project Narrative Neural circuits in the inferior colliculus contribute to speech recognition, sound localization, hearing in noise, and other computations that are essential for hearing. The proposed research is expected to determine how two novel classes of inferior colliculus neurons process identified sources of input, influence targets in other brain regions, and respond to simple and complex sounds. These results will provide a framework for understanding how defined neural circuits in the inferior colliculus support sound processing and how auditory prostheses can more effectively engage these circuits to improve hearing for the hearing impaired.

PI_NAMEs: ROBERTS, MICHAEL THOMAS (contact)

PROGRAM_OFFICER_NAME: POREMBA, AMY

PROJECT_TERMS: Anatomy;Auditory;auditory processing;Auditory Prosthesis;Auditory system;auditory thalamus;Axon;Brain;Brain region;Brain Stem;Cell Nucleus;Code;Complex;Contralateral;Data;Dendrites;Electrophysiology (science);evidence base;excitatory neuron;Excitatory Synapse;Exhibits;experimental study;falls;Family;Frequencies;Glutamates;Hearing;hearing impairment;improved;in vivo;Inferior Colliculus;inhibitory neuron;Inhibitory Synapse;insight;Intervention;Investigation;Knowledge;Label;Maps;Measures;Midbrain structure;Molecular;molecular marker;Morphology;neural circuit;Neurons;neuropeptide Y;Neurophysiology - biologic function;Noise;novel;optogenetics;Outcomes Research;Output;Pattern;Physiological;Physiology;Play;Population;postsynaptic;postsynaptic neurons;Process;Property;receptive field;Research;response;Role;Sampling;Shapes;Slice;sound;sound frequency;Sound Localization;Source;Speech;speech in noise;speech recognition;stellate cell;Stimulus;superior colliculus Corpora quadrigemina;Synapses;Synaptic Transmission;System;Testing;Time;tool;Training Activity;Vasoactive Intestinal Peptide;Viral;vocalization

PROJECT_TITLE: Circuit Mechanisms for Auditory Processing in the Inferior Colliculus

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: Project Narrative Phagocytosis is a fundamental biological process in development, tissue homeostasis, and immune defense whereby extracellular material is engulfed by phagocytes and subsequently degraded. Phagocytosis proceeds via a series of steps which begins with cargo recognition, engulfment, and phagosome maturation; however, the molecular details by which this occurs remain unclear. Our research program seeks to develop a quantitative, molecular understanding of how phagosome biology is controlled with the ultimate goal of addressing fundamental questions in cell biology and using this knowledge to advance therapies where appropriate phagosome activity is essential.

PI_NAMEs: BRYSON, BRYAN DAVID (contact)

PROGRAM_OFFICER_NAME: LEWIS, MECHELLE MAYLEBEN

PROJECT_TITLE: High-dimensional characterization of phagosome composition, control and phagocytic receptor redundancy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-H(55)R]


ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: NARRATIVE The UCSD Training Program in Experimental Endocrinology takes a multidisciplinary approach to prepare Physician and Ph.D. scientists to become the future leaders in academic medicine and in biopharmaceutical companies related to healthcare. Ph.D. and/or M.D. scholars will be trained in the fields of endocrinology and metabolism including thyroid disease, bone metabolism, diabetes, lipid metabolism and atherosclerosis through advanced basic research experiences in world-class laboratories, or by engaging in state-of-the art clinical investigation. Outstanding Faculty from the Division of Endocrinology in the Department of Medicine, and from other related basic and clinical departments, chosen to be Mentors in this program because of their proven records of fostering and encouraging careers of their Trainees, will prepare our Trainees to be future leaders in the field of Experimental Endocrinology and Metabolism.

PI_NAMEs: WEBSTER, NICHOLAS J (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Endocrinology

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


NIH_SPENDING_CATS: Genetics

ORG_CITY: STANFORD

ORG_DEPT: BIOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative Translation in eukaryotic organisms represents a final point of genetic regulation. Here we apply biochemistry, biophysics and structural biology to illuminate the mechanism of translation initiation, elongation and termination in real time, and probe the origins of regulation by RNA structure, RNA modifications and regulatory proteins. .

PI_NAMEs: PUGLISI, JOSEPH D (contact)

PROGRAM_OFFICER_NAME: REDDY, MICHAEL K

PROJECT_TERMS: Area;Binding;Binding Proteins;Biochemical;Biochemistry;Biophysics;Code;Complex;Cryoelectron Microscopy;Disease;Event;Funding;Gene Expression;Genetic;genetic regulatory protein;Grant;Health;Human;Kinetics;Messenger RNA;method development;Methods;Modification;Molecular Conformation;Nonsense Codon;Nonsense-Mediated Decay;Nucleotides;Organism;Pathway interactions;Process;protein folding;Quality Control;Reagent;Recycling;Regulation;Research;Ribosomes;RNA;Role;single molecule;structural biology;Structure;Terminator Codon;Time;Translation Initiation;Translations;Yeasts

PROJECT_TITLE: Dynamics of Translation

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: BOSTON

ORG_NAME: BOSTON MEDICAL CENTER

PHR: PROJECT NARRATIVE The goal of our study is to leverage telemedicine to improve evidence-based management of acute respiratory tract infections (ARTIs) across different healthcare settings and for patients of different racial/ ethnic and socioeconomic backgrounds. ARTIs are the most common reason for antibiotic prescriptions in ambulatory care, and half of the prescriptions are inappropriate. We will use a mixed methods approach and a multisite implementation strategy to identify patients appropriate for telehealth visits (THVs) for ARTIs, create appropriate materials for the THV in collaboration with providers and patients, and gauge implementation and effectiveness outcomes.

PI_NAMEs: BARLAM, TAMAR  (contact);DRAINONI, MARI-LYNN

PROGRAM_OFFICER_NAME: HENDERSON, SUSAN

PROJECT_TITLE: Implementing Telemedicine to Improve Appropriate Antibiotic Prescribing for Acute Respiratory Tract Infections

STUDY_SECTION: HSQR

STUDY_SECTION_NAME: Healthcare Patient Safety and Quality Improvement Research[HSQR]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Prevention

PHR: PROJECT NARRATIVE Beta-amyloid plaques and neurofibrillary tangles are characteristic of Alzheimer’s disease (AD), but white matter lesions of presumed vascular origin are an independent contributor to cognitive decline in AD patients. Capillary dysfunction has been proposed as a potential physiological mechanism contributing to white matter lesion burden, but white matter hemodynamic impairment underlying these lesions remains unclear. The goal of this work is to characterize white matter hemodynamic function in older adults at elevated risk for AD using 7 Tesla magnetic resonance imaging (MRI) protocols.

PI_NAMEs: JUTTUKONDA, MEHER R (contact)

PROGRAM_OFFICER_NAME: ROVESCALLI, ALESSANDRA C

PROJECT_TERMS: Academic Training;Address;Affect;Age;Aging;aging population;aging related;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease risk;American;Amyloid;arterial spin labeling;Award;Biological Markers;Blood capillaries;blood oxygen level dependent;Blood Vessels;career;Cerebrovascular Circulation;Cerebrovascular Disorders;cerebrovascular reactivity;Characteristics;Cognitive;cohort;Data;Dementia;Development;Diagnosis;Disease Marker;disorder risk;Early identification;Enrollment;Etiology;Foundations;Functional disorder;Funding;Future;Gases;General Hospitals;Goals;gray matter;hemodynamics;High Prevalence;high risk population;human old age (65+);human study;hypoperfusion;Image;imaging approach;imaging biomarker;imaging modality;Impaired cognition;Impairment;insight;instructor;interest;Lesion;longitudinal design;longitudinal human study;Magnetic Resonance Imaging;Massachusetts;Measures;medical schools;method development;Methods;Microvascular Dysfunction;Neurofibrillary Tangles;Noise;novel;older adult;Oxygen;Pattern;Perfusion;Pericytes;Phase;Physiological;Physiology;Play;Pre-Clinical Model;Predisposition;Prevalence;prevent;Preventive therapy;Process;Property;Protocols documentation;Publications;Radiology Specialty;Regulation;Reporting;Research;Research Design;Research Personnel;response;Role;Senile Plaques;Series;Signal Transduction;Stimulus;success;symposium;targeted treatment;Testing;theories;therapeutic development;Therapeutic Intervention;therapy development;Training;Venous;white matter;Work

PROJECT_TITLE: Microvascular mechanisms underlying white matter lesions in older adults

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Clinical and Translational Research of Aging Study Section[NIA -T]


NIH_SPENDING_CATS: Biotechnology;Eye Disease and Disorders of Vision;Genetics;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Wound Healing and Care

ORG_CITY: Chicago

ORG_NAME: NORTHWESTERN UNIVERSITY

ORG_STATE: IL

PHR: Project Narrative Mammals after injury will not be able to replace the missing tissue with new identical tissue but will form a scar which losses some of its functionality compared to the original tissue. This project will investigate how early injured induced signals and patterning during regeneration is regulated by microtubules. These studies are important in determining the how microtubules initiate regeneration, how motor proteins regulate patterning genes and could implicate roles novel roles of microtubules human regeneration.

PI_NAMEs: ANDERSON, XAVIER N (contact)

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TERMS: Adult;Animals;Anterior;beta catenin;Cell Differentiation process;Cell Maturation;cell type;Cells;Chemicals;Cicatrix;Data;Decapitation;Ectoderm;Endoderm;Event;experimental study;Eye;eye formation;eye regeneration;Fluorescent in Situ Hybridization;Fresh Water;Gene Expression;Genes;Genetic Epistasis;Germ Layers;Goals;Growth;Head;Human;In Situ Hybridization;inhibitor;injured;Injury;insight;Instruction;Kinesin;Limb structure;Mammals;Mesoderm;Microtubules;Minus End of the Microtubule;Modeling;Molecular;Motor;Muscle;Muscle Cells;Muscle Fibers;Natural regeneration;neuronal cell body;novel;Organ;Organism;Pathway interactions;Pattern;Pharmaceutical Preparations;Phenotype;Planarians;Platyhelminths;Pluripotent Stem Cells;Process;Proteins;Regenerative capacity;Regenerative pathway;Regenerative response;Regulation;response;response to injury;restoration;RNA Interference;Role;Signal Induction;Signal Transduction;Site;small molecule;Specific qualifier value;stem cells;stemness;Structure;Surgical Injuries;Surgical wound;Tail;Testing;tissue regeneration;Tissues;Transport Process;Wnt proteins;WNT Signaling Pathway;wound

PROJECT_TITLE: F31 Microtubule function in the onset of whole-body regeneration

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-Q(20)L]