FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Epilepsy;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: NEW YORK

ORG_DEPT: PATHOLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE Nearly all glioma patients experience seizures. The brain tumor microenvironment has been shown to be a crucial regulator of cancer initiation and progression, specifically neuronal activity has been shown to impact glioma cell proliferation. The interaction between neurons, microglia, and glioma cells is poorly understood. This proposal aims to investigate the cohesive interactions between neuronal activity, microglia, and glioma cells.

PI_NAMEs: GOLDBERG, ALEXANDER  (contact)

PROGRAM_OFFICER_NAME: PURI, ANU

PROJECT_TERMS: Acceleration;Acute;angiogenesis;antagonist;anti-epileptic agents;Automobile Driving;barrel cortex;Binding;Brain;Brain Neoplasms;Calcium;Calcium ion;Calcium Signaling;cancer initiation;CCL3 gene;Cell Density;cell growth;Cell Proliferation;Cells;Chronic;Communication;CXCL2 gene;cytokine;Data;design;Electroencephalography;Epilepsy;epileptiform;Epileptogenesis;Event;Exhibits;experience;Family;Frequencies;glial activation;Glioma;Gliosis;Growth;Histologic;Image;In Situ Hybridization;in vivo calcium imaging;in vivo imaging;Infiltration;Inflammatory;Inflammatory Response;inhibitor;Injections;Interleukin-1 beta;Interleukin-6;Link;Measurement;Measures;Mediating;Microglia;migration;Monitor;mRNA Expression;Mus;Neuroglia;Neurons;neurotransmission;P2X-receptor;Pathologic;Patients;PDGFA gene;Penetrance;Process;Proliferating;Purines;Purinoceptor;receptor;receptor expression;Reporting;Resected;response;Role;Seizures;Sensory;Severities;Signal Transduction;Stimulus;Testing;TNF gene;TP53 gene;tumor;tumor microenvironment;tumor progression;Tumor Promotion;Vibrissae

PROJECT_TITLE: Targeting Neuron-Microglia Interactions at the Margin of Glioma


ADMINISTERING_IC: NS

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Neurosciences;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: BLACKSBURG

ORG_COUNTRY: UNITED STATES

ORG_DEPT: OTHER BASIC SCIENCES

ORG_FIPS: US

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

ORG_STATE: VA

PHR: PROJECT NARRATIVE Limited information exists pertaining to the physiological relevance of innate immune regulation across the age spectrum following TBI. Completion of these studies will advance our understanding of the key regulators involved in monocyte/macrophage responses and neurovascular health in TBI pathophysiology. Exploiting the pro-resolving phenotype of juvenile- derived PDMs may provide a novel restorative intervention aimed at improving TBI outcomes and reveal novel targets for drug discovery.

PI_NAMEs: THEUS, MICHELLE LEE (contact)

PROGRAM_OFFICER_NAME: AWWAD, HIBAH OMAR

PROJECT_TERMS: Acceleration;Acute;Adolescent;Adult;Affect;Age;age difference;age related;age related changes;aged;Attenuated;Behavior;Behavioral;behavioral phenotyping;Biochemical;Blood - brain barrier anatomy;Blood brain barrier dysfunction;Blood Vessels;Brain Injuries;Cells;central nervous system injury;Cerebrovascular Circulation;Chronic;Data;disability;drug discovery;Endothelial Cells;EphA4 Receptor;epigenomics;Female;Functional disorder;functional outcomes;genome-wide;genome-wide analysis;Goals;Health;Hippocampus;Histologic;IL4 gene;Immune;Immunologics;immunoregulation;improved;In Vitro;in vivo;Infiltration;Inflammation;Inflammatory;inflammatory milieu;Injury;Innate Immune Response;innovation;Intervention;Lesion;Macrophage;male;Mediating;Microglia;Molecular;monocyte;mouse model;Mus;neuroinflammation;neuron loss;neuroprotection;neurotoxic;neurovascular;neurovascular injury;neutrophil;new therapeutic target;novel;novel strategies;Outcome;Pathogenesis;Pathogenicity;Patients;Peripheral;Phagocytes;pharmacologic;Phenotype;Physiological;porcine model;postnatal;pre-clinical;preclinical study;Process;protective effect;Publishing;Receptor Cross-Talk;Recovery;Recovery of Function;repaired;Reporter;Research;response;response to injury;restoration;Rodent Model;Role;Technology;Testing;Time;Tissues;tool;transcriptomics;Transgenic Mice;Transgenic Organisms;Traumatic Brain Injury;Traumatic Brain Injury recovery

PROJECT_TITLE: Divergent age-dependent peripheral innate immune response following TBI

STUDY_SECTION: BINP

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Building Research Capacity at Institutions with Limited NIH Funding;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: FULLERTON

ORG_DEPT: BIOLOGY

ORG_NAME: CALIFORNIA STATE UNIVERSITY FULLERTON

ORG_STATE: CA

PHR: Project Narrative Acinetobacter baumannii has posed a serious threat to human health worldwide. This project further expands our observation that Human Serum Albumin (HSA) plays a role in the ability of A. baumannii to emerge as a hard pathogen to be treated and will determine the mechanistic aspect of this host pathogen interaction. Knowledge gained from this study would potentially identify new/alternative targets much needed for the development of novel approaches to control A. baumannii antibiotic resistance.

PI_NAMEs: RAMIREZ, MARIA SOLEDAD (contact)

PROGRAM_OFFICER_NAME: BERNAL, FEDERICO

PROJECT_TERMS: Acinetobacter;Acinetobacter baumannii;Acinetobacter Infections;Address;Affinity;Agreement;anti-microbial drug;Antibiotic Resistance;Bacteria;Bacterial Antibiotic Resistance;base;Biotin;Categories;Cell Communication;Cell Surface Proteins;Cell Surface Receptors;Cells;Centers for Disease Control and Prevention (U.S.);Characteristics;ChIP-seq;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Code;Competence;Complementary RNA;Complex;Conjugating Agent;crosslink;Data;Development;differential expression;DNA;DNase-I Footprinting;Drops;EMSA;Enterobacteriaceae;Environment;extracellular;Funding;Future;Gene Expression;Genes;Genetic;Genetic Transcription;Genome;Genomics;Gram-Positive Bacteria;Health;Human;Infection;insight;Integration Host Factors;Knowledge;Ligands;Link;Liquid substance;Mass Spectrum Analysis;Mediating;Membrane;Methodology;Molecular;Multi-Drug Resistance;Multidrug-resistant Acinetobacter;mutant;Nosocomial Infections;novel strategies;opportunistic pathogen;pathogen;pathogenic bacteria;Pathway interactions;Physiology;Play;Process;promoter;receptor;Reporting;Repression;Resistance;resistance gene;response;Role;Serum Albumin;Signal Transduction;Signaling Molecule;Streptavidin;Surface;System;Techniques;Testing;Therapeutic;tool;trait;transcription factor;transcriptome sequencing;treatment strategy;uptake;Virulence

PROJECT_TITLE: Identifying host human products responsible for natural transformation of resistance traits in Acinetobacter spp


ADMINISTERING_IC: ES

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: American Indian or Alaska Native;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: CAMBRIDGE

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

ORG_STATE: MA

PHR: PROJECT NARRATIVE This R25 Short Course program will impact public health by teaching environmental health and genetics to nurses and health care professionals serving Indigenous and marginalized populations. Utilizing the courses’ teachings on communication, nurses will translate public health messages to community members. The scientific workforce will also be broadened as the Short Course promotes careers in environmental public health research.

PI_NAMEs: VANDIVER, KATHLEEN MEAD (contact)

PROGRAM_OFFICER_NAME: GARTON, AMANDA E

PROJECT_TERMS: Advisory Committees;Attention;Award;Awareness;Care given by nurses;career;Cheyenne;Collaborations;college;Communication;Communities;community building;Community Health;Community Healthcare;Complex;Critiques;Development;Discipline of Nursing;Distance Learning;DNA;Education;education research;Educational Curriculum;Educational process of instructing;Environmental Exposure;Environmental Health;environmental justice;environmental toxicology;Evaluation;Familiarity;Feedback;follow-up;Follow-Up Studies;formative assessment;Foundations;Funding;gene environment interaction;Genes;Genetic;Genetic Predisposition to Disease;Genomics;Grant;Growth;Hand;Health;health communication;health disparity;Health education;health practice;Health Professional;Health Resources;health training;improved;Institution;Instruction;Internships;Knowledge;Lead;Learning;Learning Skill;lectures;Legal patent;Lenape Tribal Nation;marginalized community;marginalized population;Measures;member;Methods;Modeling;Molecular;Molecular Biology;multidisciplinary;Mutation;National Institute of Environmental Health Sciences;Native-Born;New Jersey;novel;Nurses;Nursing Education;Nursing Students;Outcome;Participant;peer;Persons;Process;programs;project-based learning;Proteins;prototype;Public Health;public health research;Quality of life;Research;Research Personnel;Research Project Grants;Resources;response;Rural;Series;Set protein;Sioux Indians;skills;South Dakota;Structural Models;Structure;success;symposium;Techniques;Testing;Training;Translating;tribal college;tribal community;Tribes;Vulnerable Populations;web site;Work

PROJECT_TITLE: Short Courses for Teaching Gene-Environment Interactions with a focus on Environmental Justice Communities


ADMINISTERING_IC: HL

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular

ORG_CITY: SHREVEPORT

ORG_NAME: LOUISIANA STATE UNIV HSC SHREVEPORT

ORG_STATE: LA

PHR: While new classes of drugs and advances in surgical interventions has reduced the cardiovascular mortality rate, cardiovascular disease incidence has begun to rise again in recent years, suggesting a continued investment in biomedical research will be critical to further reduce residual cardiovascular disease risk. Due to the complexity of cardiovascular disease and advanced research techniques used to understand these disease processes, it is imperative that the next generation of research scientists receive training across a variety of disciplines, including cardiovascular physiology, cellular and molecular biology, and disease pathogenesis. The goal of the Multidisciplinary Training in Cardiovascular Pathophysiology (MCTP) Training Program is to establish a research program to meet the need for advanced interdisciplinary training for Predoctoral Fellows and to provide a diverse pool of scientists to the study of cardiovascular disease.

PI_NAMEs: ORR, ANTHONY WAYNE (contact);STOKES, KAREN Y

PROGRAM_OFFICER_NAME: LIDMAN, KARIN FREDRIKSSON

STUDY_SECTION: NITM

STUDY_SECTION_NAME: NHLBI Institutional Training Mechanism Study Section[NITM(JA)]


ORG_CITY: DURHAM

ORG_DEPT: PHARMACOLOGY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: This proposal seeks to uncover new mechanisms, pathways, and targets for addressing neuroinflammation and neurodegeneration associated with Parkinson's disease and Lewy-body dementias.

PI_NAMEs: WEST, ANDREW B (contact)

PROGRAM_OFFICER_NAME: SULLIVAN, LUIS FLANAGAN

PROJECT_TERMS: Address;Affect;AGFG1 gene;alpha synuclein;Alzheimer's Disease;Alzheimer's disease related dementia;American;Attention;Attenuated;Autopsy;Binding;Biochemical;Bone Marrow;Bone Marrow Cells;Bone Marrow Transplantation;Brain;brain cell;Catalytic Domain;Cells;chemokine;Chemotaxis;Clinic;Clinical;Complement;Crohn's disease;Cryoelectron Microscopy;Cytoplasm;Dementia;Disease;disease model;Disparate;dopaminergic neuron;Excision;experimental study;Future;Gene Expression;gene function;Gene Modified;Gene Mutation;Gene Targeting;Genes;Genetic;genetic risk factor;genetic variant;Guanosine Triphosphate;Guanosine Triphosphate Phosphohydrolases;Immune;Immune response;Immune system;Impaired cognition;In Vitro;Inflammatory;Inflammatory Response;inhibitor;Knock-out;knockout gene;Label;Lewy Body Dementia;Lewy Body Disease;Life;Link;Longitudinal Studies;LRRK2 gene;Macrophage;Maps;Mass Spectrum Analysis;Measures;Mediating;Membrane;Microtubules;Missense Mutation;Modeling;Modification;Molecular Conformation;molecular sequence database;monocyte;motor impairment;mouse model;mouse synuclein alpha;Mus;mutant;Mutation;mutation carrier;Mycobacterium Infections;Myeloid Cells;Nerve Degeneration;neuroinflammation;Neurons;neurotoxicity;novel;Onset of illness;Output;overexpression;Parkinson Disease;Pathogenicity;Pathway interactions;Peripheral;pharmacologic;Phenotype;Phosphorylation;Phosphotransferases;Predisposition;protein complex;recruit;Resolution;response;Role;Safety;Series;Signal Transduction;single cell sequencing;Structure;Structure-Activity Relationship;Substrate Interaction;success;synuclein;synucleinopathy;targeted treatment;tau aggregation;Techniques;Testing;Time;Tissues;tool;Variant;Vesicle;virulence gene;Work

PROJECT_TITLE: Mechanisms of LRRK2 Mediated Neurotoxicity

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


ADMINISTERING_IC: AI

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Infectious Diseases;Malaria;Neurosciences;Rare Diseases;Vector-Borne Diseases

ORG_CITY: MOSCOW

ORG_NAME: UNIVERSITY OF IDAHO

ORG_STATE: ID

PHR: Project Narrative Nearly 60% of the global population is at risk for malaria, a disease caused by mosquito-borne parasites that circulate in human blood. These studies focus on two molecules, histamine and serotonin, which circulate in blood, are associated with dangerous symptoms of malaria, and are ingested by mosquitoes when they feed on blood. We hypothesize that ingested histamine and serotonin alter mosquito physiology to favor malaria parasite transmission, suggesting that future interventions to block these small molecules in humans would reduce both disease and mosquito transmission.

PI_NAMEs: LUCKHART, SHIRLEY  (contact);RIFFELL, JEFFREY A

PROGRAM_OFFICER_NAME: COSTERO-SAINT DENIS, ADRIANA

PROJECT_TERMS: Abdomen;Aedes;Anopheles Genus;antagonist;Behavior;behavior influence;Behavioral;Biogenic Amine Receptors;Biogenic Amines;Biological Assay;Biology;Bite;Blood;Body Size;Brain;Brain region;Cerebral Malaria;Clinical;Clutch Size;Collaborations;Coma;Culicidae;Dangerousness;Data;Development;Disease;Disease Progression;Enzymes;Falciparum Malaria;feeding;Feeding behaviors;Fertility;Future;Genes;Goals;Head;Histamine;Histamine Receptor;Histamine Release;Human;human disease;Hyperphenylalaninaemias;improved;Infection;Ingestion;innovation;Insecta;insulin-like peptide;Interruption;Intervention;Investments;Knowledge;life history;life span;Liver diseases;Malaria;Maps;mathematical model;Mediating;Metabolism;Midgut;Modeling;mosquito-borne;Mus;Neuromodulator;Neurons;neurophysiology;neurotransmission;novel;olfactory stimulus;Parasite Control;Parasites;Parasitic infection;Pathology;Pattern;Pharmacotherapy;Physiological;Physiology;Plasma;Plasmodium berghei;Plasmodium falciparum;Plasmodium yoelii;Population;Publishing;receptor;receptor expression;Reporting;Reproduction;reproductive;Resistance;response;Retina;Risk;Sensory;Serotonin;serotonin receptor;Severities;Signal Transduction;small molecule;Sporozoites;success;Symptoms;trait;Transcript;transmission process;treatment effect;Tryptophan;Tyrosine;vector mosquito;vector transmission;Vectorial capacity;Visual;visual stimulus

PROJECT_TITLE: Biogenic amines, malaria and manipulation of mosquito physiology and behavior.

STUDY_SECTION: VB

STUDY_SECTION_NAME: Vector Biology Study Section[VB]


ORG_CITY: COLLEGE STATION

ORG_DEPT: CHEMISTRY

ORG_NAME: TEXAS A&M UNIVERSITY

ORG_STATE: TX

PHR: PROJECT NARRATIVE  This proposal will use high-level calculations and experiments to improve our knowledge of the factors controlling reactivity and selectivity and to develop new sustainable catalytic reactions. New reagents, catalysts, and chemical reactions are expected to provide rapid access to untapped chemical space and synthesis of compounds with desirable properties for applications to human health.

PI_NAMEs: GUTIERREZ, OSVALDO  (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TITLE: Merging Computation and Experiment to Understand and Develop Asymmetric Open-Shell Radical Cross- Couplings

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-P(55)R]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Nanotechnology;Neurosciences;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: PITTSBURGH

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Narrative Hydrogels derived from extracellular matrix induce brain tissue regeneration by attracting brain cells into the stroke cavity. However, little is known about the spatio-temporal characteristics of neural progneitors migrating from the subventricular zone to the bioscaffold. A major limitation to map and understand the contribution of neurogenesis to brain tissue regeneration is the lack of in vivo imaging tools that can be utilized to visualize this process. We here described a novel method in which we inject gadolinium- gold nanoparticles into the lateral ventricle to tag newly born neural progenitors and track their migration using T1-weighted MRI. The positive signal emanating from these cells can unequivocally be attributed to labeled cells and allow us to increase spatial resolution to resolve a very detailed brain anatomy, specifically the tissue-bioscaffold interface. We further here propose to conduct experiments that will exploit this in vivo MR imaging to study the role neurogenesis plays in brain tissue regeneration. These studies will dramatically improve our ability to further develop bioscaffold for tissue regeneration.

PI_NAMEs: MODO, MICHEL M. (contact)

PROGRAM_OFFICER_NAME: LAVAUTE, TIMOTHY M

PROJECT_TERMS: Ablation;Adult;adult neurogenesis;analytical tool;Anatomy;bioscaffold;Brain;brain cell;brain tissue;cell motility;Cells;Characteristics;Complex;Contrast Media;Control Groups;Data;Date of birth;design;Detection;Development;Engineering;Ensure;experimental study;Extracellular Matrix;Fluorescence Microscopy;Gadolinium;Generations;Histologic;histological studies;Histology;Hydrogels;Imaging Device;Immunohistochemistry;Implant;implantation;improved;in vivo;in vivo imaging;Infarction;Injections;Injury;insight;Invaded;Label;Lateral;lateral ventricle;Magnetic Resonance Imaging;Mammals;Maps;meter;Methods;migration;Modality;Modification;nanoGold;Natural regeneration;nerve stem cell;neural;neurogenesis;Neurons;Noise;novel;novel strategies;Outcome;Play;Process;progenitor;Regenerative Medicine;Resolution;response;Role;Route;Signal Transduction;Site;Source;spatiotemporal;Specificity;Speed;stem cell migration;Stroke;subventricular zone;Testing;Time;tissue regeneration;Tissues;tool;Up-Regulation;Visualization

PROJECT_TITLE: MR Imaging of Bioscaffold-Induced Neural Progenitor Migration

STUDY_SECTION: IPCA

STUDY_SECTION_NAME: Imaging Probes and Contrast Agents Study Section[IPCA]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Cost Effectiveness Research;Dissemination and Implementation Research;Emergency Care;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Mental Illness;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Suicide;Suicide Prevention

ORG_NAME: NEW YORK UNIVERSITY

ORG_STATE: NY

PHR: PROJECT NARRATIVE  The challenges of suicide prevention among Black youth are manifold. Many suicidal Black youth are unidentified, fewer than half are referred to treatment following an emergency department visit, and many referred youth do not adhere to treatment. Yet, prior research has not examined the effectiveness of a system of care for Black youth that combines suicide risk screening with an intervention to enhance linkage to quality mental health services.

PI_NAMEs: KING, CHERYL A.;LINDSEY, MICHAEL A. (contact);MORRIS-PEREZ, PAMELA A

PROGRAM_OFFICER_NAME: BURSTEIN, MARCY ELLEN

PROJECT_TERMS: acceptability and feasibility;Accident and Emergency department;Address;Administrator;Adolescent;Advisory Committees;Age;Attitude;Black race;boys;care systems;Caregivers;Caring;Communities;computerized;Cost Effectiveness Analysis;Detection;Development;Effectiveness;effectiveness clinical trial;effectiveness evaluation;effectiveness trial;Emergency department visit;Emergency medical service;Emergency Situation;Enrollment;Equity;evidence base;experience;Family;Feeling suicidal;follow-up;gender minority status;Goals;high risk;high school;Hospitalization;Hospitals;implementation facilitation;implementation framework;implementation science;improved;Intervention;intervention refinement;Knowledge;Male Adolescents;Manuals;Mediating;Mediator;Medical Records;Mental Health;Mental Health Services;National Institute of Mental Health;New York City;Parents;Perception;Policies;Population;prevent;Prevention;Prevention strategy;Probability;Protocols documentation;Psyche structure;psychologic;Randomized;Recommendation;reducing suicide;Reporting;Research;Risk;School-Age Population;screening;Self Efficacy;Services;sex;sexual minority;suicidal;suicidal adolescent;suicidal behavior;suicidal risk;Suicide;Suicide attempt;Suicide prevention;Surveys;System;Technology;Testing;Text Messaging;Training;user-friendly;Work;Youth

PROJECT_TITLE: Answering the Alarm:  A System of Care for Black Youth at Risk for Suicide


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Attention Deficit Hyperactivity Disorder (ADHD);Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Mental Health;Osteoporosis;Pediatric;Stimulant Use and Misuse

ORG_CITY: HOUSTON

ORG_DEPT: PSYCHIATRY

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE  Psychostimulants, which are the second most prescribed medication class for long-term use in children and adolescents with attention deficit hyperactivity disorder (ADHD), increase osteoclast differentiation and activity, promoting bone resorption. This observational study in 7 to 16 year-olds starting treatment for ADHD will be the first to prospectively examine whether psychostimulants impair bone microarchitecture and mineral accrual during this critical developmental period, increasing one's risk for low bone mass later in life.

PI_NAMEs: CALARGE, CHADI A. (contact)

PROGRAM_OFFICER_NAME: REN, ZHAOXIA

PROJECT_TERMS: 11 year old;16 year old;17 year old;19 year old;Accounting;Adolescent;Adolescent and Young Adult;Affect;Aftercare;Age;age group;Amphetamines;Antipsychotic Agents;Attention deficit hyperactivity disorder;bone;Bone Density;bone fragility;bone mass;Bone Mineral Contents;bone quality;Bone Resorption;bone strength;boys;calcium intake;Child;Chronic;clinically significant;comparison group;Confounding Factors (Epidemiology);Control Groups;cortical bone;critical developmental period;Data;Data Set;design;Development;Diagnosis;Distal;Dose;Drug Prescriptions;Dual-Energy X-Ray Absorptiometry;Enrollment;Exclusion;Failure;Family;Female;Femur;Fracture;fracture risk;Funding;girls;Growth;Height;Hip region structure;Impairment;Intervention;Knowledge;Life;Longitudinal Studies;Longitudinal, observational study;male;Mediating;Medical;medication safety;Minerals;Monitor;National Health and Nutrition Examination Survey;Neck;Observational Study;Osteoclasts;Outcome;Participant;Patients;Peripheral;Pharmaceutical Preparations;Physical activity;Polypharmacy;pre-clinical research;preference;prepuberty;Prevalence;prospective;Prospective Studies;Psychopathology;psychostimulant;Puberty;Publishing;Race;Radial;Rattus;Resolution;Risk;risk mitigation;Risperidone;Ritalin;Scanning;secondary analysis;Selective Serotonin Reuptake Inhibitor;sex;skeletal;stimulant use;substantia spongiosa;tibia;Vertebral column;Vitamin D;X-Ray Computed Tomography;young adult

PROJECT_TITLE: Examining the Skeletal Effects of Psychostimulants


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Aging;Bioengineering;Biomedical Imaging;Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Precision Medicine;Prevention;Women's Health Research

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: PROJECT NARRATIVE Despite improvements in screening and treatment, breast cancer remains the 2nd most common cause of cancer related death among U.S. women. With current EDRN funding we conducted successful Phase 2 and 3 validation studies of breast cancer biomarkers for clearly defined clinical applications. Herein we propose Phase 2, 3, and 4 validation studies, development of clinical grade assays, and integration of imaging data with the goal of implementing a novel strategy to improve the early detection of breast cancer.

PI_NAMEs: LI, CHRISTOPHER I (contact);PARTRIDGE, SAVANNAH CORRINA

PROGRAM_OFFICER_NAME: FU, SIDNEY WANG

PROJECT_TERMS: Algorithms;Area;Artificial Intelligence;artificial intelligence algorithm;Biological Assay;Biological Markers;Biological Specimen Banks;biomarker development;biomarker panel;Biometry;Blood;Blood specimen;blood-based biomarker;Breast;Breast Cancer Detection;Breast Cancer Early Detection;Breast Cancer Risk Factor;breast imaging;Breast Magnetic Resonance Imaging;Cancer Biology;cancer biomarkers;Cancer Etiology;cancer type;candidate marker;Cessation of life;CLIA certified;Clinical;clinical application;clinical development;cohort;Collaborations;Colorectal;Colorectal Cancer;computer scientist;Data;design;design verification;Development;Diagnostic;early detection biomarkers;Early Detection Research Network;Epidemiology;Estrogen receptor positive;Funding;Future;Goals;good laboratory practice;high risk;High Risk Woman;Image;improved;industry partner;Lead;Leadership;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of ovary;Malignant neoplasm of prostate;Mammographic screening;Mammography;Mass Spectrum Analysis;Methodology;multidisciplinary;multimodality;novel;novel strategies;Oncology;Ovary;Paper;patient screening;Patients;Performance;Phase;phase 2 study;phase 3 study;phase 3 testing;phase 4 study;Positioning Attribute;pre-clinical;predictive modeling;prospective;Prospective cohort;protein biomarkers;Public Health;Research Design;Research Personnel;Resources;Sampling;screening;Series;Techniques;Testing;Tissue Sample;tool;Tumor Tissue;Universities;Validation;validation studies;Washington;Woman;Women's cohort;Women's Health;Work

PROJECT_TITLE: Fred Hutchinson Breast Cancer Clinical Validation Center


NIH_SPENDING_CATS: Nutrition

ORG_CITY: DETROIT

ORG_NAME: WAYNE STATE UNIVERSITY

ORG_STATE: MI

PHR: PROJECT NARRATIVE The dynamic regulation of metabolic pathways is critical for cellular adaptation to stress and starvation and ultimately cell survival. We found that inter-organelle contact sites are hotspots for spatially coordinating the interplay between lipids and methionine metabolism. By understanding how changes in methionine metabolism influence the lipidome, we will make important insights into the mechanisms underlying various human pathologies including cancers, liver diseases, and cardiovascular diseases.

PI_NAMEs: HARIRI, HANAA  (contact)

PROGRAM_OFFICER_NAME: NIE, ZHONGZHEN

PROJECT_TERMS: Aging;Biological Models;Cardiovascular Diseases;Cell Physiology;Cell Survival;Coupling;deprivation;Endoplasmic Reticulum;Enzymes;epigenetic regulation;Equilibrium;Goals;Human Pathology;insight;Link;Lipid Binding;lipid biosynthesis;lipid metabolism;lipid transport;lipidome;Lipids;Liver diseases;Lysosomes;Malignant Neoplasms;Membrane;Membrane Lipids;Metabolic Diseases;Metabolic Pathway;Metabolism;Methionine;Methionine Metabolism Pathway;methyl group;Methylation;Molecular;Neurodegenerative Disorders;Nutrient;Organelles;Oxidation-Reduction;Pathway interactions;Phospholipids;recruit;Regulation;response;Role;S-Adenosylhomocysteine;S-Adenosylmethionine;Signal Transduction;Site;Starvation;Stress;Testing;Yeasts

PROJECT_TITLE: Subcellular mechanisms coupling lipid synthesis and methionine metabolism

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CDB-B(55)R]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;HIV/AIDS;Health Services;Infectious Diseases;Precision Medicine

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE The optimal strategy for management of people who experience treatment failure on tenofovir, lamivudine, and dolutegravir (TLD), the preferred first-line antiretroviral therapy regimen for over 25 million people in sub- Saharan Africa, is unknown. In this project, we will respond to this critical knowledge gap by conducting a randomized clinical trial in Uganda and South Africa to determine the most effective management strategy for people with treatment failure on TLD and will leverage data from the clinical trial to conduct a modeling analysis, which will compare the cost-effectiveness of each approach. Our results will inform regional HIV guidelines by identifying the most clinically effective and cost-effective strategy for the management of treatment failure on TLD in sub-Saharan Africa.

PI_NAMEs: MCCLUSKEY, SUZANNE  (contact)

PROGRAM_OFFICER_NAME: HUEBNER, ROBIN E

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Adherence;Adolescent;Adult;Africa South of the Sahara;antiretroviral therapy;arm;Attention;Biological Assay;Caring;Clinic;Clinical;Clinical Data;Clinical Trials;comparative cost effectiveness;cost;cost effective;cost effectiveness;Data;Dose;drug intolerance;Drug resistance;Eligibility Determination;Enrollment;Ensure;epidemic response;Epidemiologist;experience;Failure;Fumarates;Funding;Genotype;Goals;Guidelines;Health system;HIV;improved;Individual;Infrastructure;innovation;International;Knowledge;Lamivudine;Leadership;life time cost;Maintenance;Modeling;models and simulation;non-nucleoside reverse transcriptase inhibitors;novel;optimal treatments;Outcome;Participant;patient oriented;Patient Preferences;Patients;personalized approach;personalized care;personalized management;Persons;pill;point of care;Policies;Positioning Attribute;Pragmatic clinical trial;prevent;primary outcome;Protease Inhibitor;Public Health;Public Sector;Randomized;randomized trial;randomized, clinical trials;Recommendation;recruit;Regimen;Reporting;Research Personnel;Research Priority;Resistance;response;Scientist;South Africa;South African;Technology;Tenofovir;Testing;Time;Treatment Failure;treatment response;Uganda;United States National Institutes of Health;Urine;Viral;Viral Load result

PROJECT_TITLE: A Randomized Clinical Trial to Evaluate Solutions for the Management of Virologic Failure for Individuals on TLD in Sub-Saharan Africa

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


NIH_SPENDING_CATS: Mental Health;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_NAME: BROAD INSTITUTE, INC.

PHR: PROJECT NARRATIVE The Scalable Molecular Pipelines for FAIR and Reusable BICAN Molecular Data CUBIE will develop common FAIR data processing pipelines, quality control measures, and process BICAN data in an open scalable environment to support the building of BRAIN Initiative Cell Atlas Network consortium brain atlases.

PI_NAMEs: GILLIS, JESSE ;TICKLE, TIMOTHY L (contact);WHITE, OWEN R

PROGRAM_OFFICER_NAME: YAO, YONG

PROJECT_TERMS: Agreement;Archives;Atlases;Biological Assay;Brain;BRAIN initiative;cell type;Cells;Charge;cloud based;Cloud Computing;Collaborations;Communities;Community Networks;Computer software;computerized data processing;cost;Data;Data Analyses;data analysis pipeline;Data Set;data standards;Development;Documentation;Ecosystem;Educational workshop;Elasticity;Engineering;Environment;FAIR principles;Funding;Generations;improved;Infrastructure;Institution;interoperability;Joints;Libraries;Measurement;Measures;member;Molecular;Output;Process;programs;Publications;Publishing;Quality Control;Reproducibility;Resources;Running;tool;Update;usability;Visualization;Visualization software;Work;working group


NIH_SPENDING_CATS: Aging;Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE Autism spectrum disorder (ASD) is a lifelong condition that affects a growing number of adults. This project will establish one of the largest and most comprehensive cohorts of autistic adults to provide critical foundations for understanding the clinical, health, neurobiological, and genetic processes associated with aging in autism and investigate whether aging is accelerated in autistic individuals. Results will provide new information identifying ways to best support and promote health, well-being, and resilience in autistic adults and provide critical information that can be used to plan appropriate services and resources for these adults.

PI_NAMEs: ALEXANDER, ANDREW L;LAINHART, JANET ELIZABETH (contact);ZIELINSKI, BRANDON A.

PROGRAM_OFFICER_NAME: GILOTTY, LISA

PROJECT_TERMS: Acceleration;Adult;adult with autism spectrum disorder;Adult women;Affect;Age;age acceleration;age effect;age related changes;age related decline;Age Years;Aging;aging related;autism spectrum disorder;autism symptoms;autistic;Biological Aging;Brain;Brain imaging;candidate identification;Clinical;Cognitive aging;cognitive function;cohort;Communities;comorbid depression;comorbidity;Data;Data Coordinating Center;data curation;Data Set;Databases;Dementia;Disease;DNA;DNA Methylation;Enrollment;Epigenetic Process;Family history of;Foundations;functional disability;Genetic;Genetic Processes;Goals;Health;Health Promotion;healthy aging;human old age (65+);imaging study;Impaired cognition;improved;improved outcome;Individual;Individual Differences;individuals with autism spectrum disorder;innovation;Learning;Life Expectancy;Life Style;Lifelong disability;Longitudinal cohort study;Longitudinal Studies;longitudinal, prospective study;male;Measurement;Measures;Mental Health;Motor;motor disorder;multidimensional data;multimodality;Nerve Degeneration;Neurobiology;Neurocognition;neuroimaging;Neurologic;older adult;Older Population;Outcome;Participant;Personal Satisfaction;Persons;physical conditioning;polygenic risk score;population health;Predictive Factor;Prevalence;prospective;Protocols documentation;Psyche structure;psychiatric comorbidity;Psychiatric Diagnosis;Psychopathology;recruit;Reporting;Research;research study;resilience;Resources;Role;Sampling;Science;Services;Severities;sex;Siblings;Statistical Data Interpretation;Structure;therapy development;Time;Universities;Utah;Variant;Visit;Wisconsin;young adult

PROJECT_TITLE: Toward Healthy Aging in Adults with Autism: A Longitudinal Clinical and Multimodal Brain Imaging Study


PHR: Project narrative The preparation of small organic molecules in efficient, concise, and convenient manner is critical for the discovery, development, and eventual production of pharmaceutical agents and other bioactive molecules for biomedical research. In this proposal, new organic reaction methodologies that employ simple and readily available alkene and alkyne containing starting materials are proposed for the expedited synthesis of molecules with direct relevance to the preparation of bioactive molecules. Thus, the successful development of these strategies will have a substantially positive impact on the achievement of public health goals.

PI_NAMEs: WANG, YIMING  (contact)

PROJECT_TERMS: Acceleration;Achievement;Alkenes;Alkynes;Area;Biomedical Research;Carbon;catalyst;Chemistry;Complex;Development;drug development;drug discovery;Electrons;functional group;Generations;health goals;Iron;Methodology;Methods;Pharmacologic Substance;pi bond;Positioning Attribute;Preparation;Production;Public Health;Reaction;Reagent;Research;Series

PROJECT_TITLE: New Strategies and Reactions for the α-C–H Functionalization and Hydrofunctionalization of Carbon–Carbon Multiple Bonds

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-Q(55)R]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Brain Disorders;Cancer;Chronic Pain;Neurodegenerative;Neurosciences;Orphan Drug;Ovarian Cancer;Pain Research;Peripheral Neuropathy;Prevention;Rare Diseases;Women's Health Research

ORG_CITY: IRVINE

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: PROJECT NARRATIVE Ovarian cancer affects only women for which cisplatin is a commonly used chemotherapeutic drug but it causes neurotoxicity leading to painful neuropathy, cognitive decline, called `chemobrain' and alterations in gait with increased propensity to fall/fractures, which may continue even after the discontinuation of treatment. We hypothesize that the activation of p38 mitogen-activated protein kinase and c-Jun N-terminal kinase plays a critical role in cisplatin-induced damage to the nervous system and that inhibition of these pathways will attenuate cisplatin-induced neurotoxic side effects in female mice with ovarian cancer. We expect that the results of our study will lead to the development of novel therapeutics to reduce the debilitating sequelae of cisplatin in women with ovarian and other cancers.

PI_NAMEs: BOTA, DANIELA ANNENELIE (contact);GUPTA, KALPNA

PROGRAM_OFFICER_NAME: CHEN, WEIWEI

PROJECT_TERMS: Adverse effects;Affect;Aftercare;Alzheimer's Disease;anticancer activity;Antineoplastic Agents;Attention;Attenuated;attenuation;Axon;axon injury;Behavioral;Bioenergetics;blood-brain barrier crossing;Brain;Breast;Breast Cancer Model;C57BL/6 Mouse;Cancer Model;Cancer Patient;cancer therapy;Cell Line;chemobrain;chemotherapeutic agent;chemotherapy;Chemotherapy-induced peripheral neuropathy;Cisplatin;Clinical;Clinical Trials;Cognitive;Cognitive deficits;cognitive testing;Data;Dendritic Spines;density;Development;Diagnosis;disability;Disease Progression;DNA Damage;Dose;druggable target;Electrophysiology (science);Epithelial ovarian cancer;Excitatory Synapse;executive function;experience;falls;FDA approved;Female;Fracture;Gait;health disparity;Hippocampus;Impaired cognition;Impairment;improved;In Vitro;in vivo;Individual;Induced Neurons;Induction of Apoptosis;Inflammation;information processing;inhibitor;Injury;Intervention;Kidney;kinase inhibitor;Length;male;Malignant Breast Neoplasm;Malignant neoplasm of ovary;Malignant Neoplasms;MAPK8 gene;Memory;men;Mitochondria;Mitochondrial DNA;Mitogen-Activated Protein Kinase Kinases;Mitogen-Activated Protein Kinases;Mitogens;Molecular;Morphology;Motor;multidisciplinary;Mus;N-terminal;Nerve;Nerve Fibers;nerve stem cell;Nervous System;neural;Neurologic;neuron apoptosis;Neurons;Neuropathy;neurotoxic;neurotoxicity;neurotransmission;novel;novel strategies;novel therapeutics;Nuclear;Numbness;ototoxicity;Ovarian;Oxidative Stress;Oxygen;p38 Mitogen Activated Protein Kinase;Pain;painful neuropathy;Painful Paresthesias;Pathway interactions;patient mobility;Patients;Performance;Peripheral;Peripheral Blood Stem Cell;peripheral nerve damage;Peripheral Nervous System;Peripheral Nervous System Diseases;Pharmaceutical Preparations;pharmacologic;Phosphotransferases;Platinum Compounds;Play;prevent;Preventive treatment;Process;processing speed;Proto-Oncogene Proteins c-jun;Quality of life;Rattus;Reporting;Rodent Model;Role;Sensory;side effect;Signal Pathway;Signal Transduction;Skin;Small Interfering RNA;small molecule inhibitor;SP600125;Spinal Ganglia;Symptoms;taxane;Testing;Therapeutic;Time;Toxic effect;Transgenic Organisms;translational potential;United States;Vinca Alkaloids;Woman

PROJECT_TITLE: Targeting p38/JNK MAPK to ameliorate cisplatin-induced adverse sequelae on the nervous system


ADMINISTERING_IC: EB

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Autoimmune Disease;Bioengineering;Biotechnology;Digestive Diseases;Genetics;Inflammatory Bowel Disease;Microbiome;Prevention

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: NORTHEASTERN UNIVERSITY

PHR: PROJECT NARRATIVE It is increasingly recognized that certain molecules produced by microbes living in the human gut play important roles in host health and disease. Controlling the concentration of these metabolites within a target window could provide new therapeutic modalities for a variety of diseases - including irritable bowel disease - but achieving this degree of control in the chemically complex, temporally variable gut environment is challenging with existing technologies. This project seeks to overcome this challenge and provide a new control strategy based on engineering commensal microbes programmed to dynamically sense and respond to the level of a target metabolite in their local environment, restoring the desired level by either degrading the compound or producing more of it.

PI_NAMEs: WOOLSTON, BENJAMIN MICHAEL (contact)

PROGRAM_OFFICER_NAME: FEHR, TUBA HALISE

PROJECT_TERMS: Anti-Inflammatory Agents;Architecture;Biological Assay;Butyrates;Chemicals;Clinical;commensal microbes;Complex;Consensus;Consumption;Crohn's disease;Data;design;design,build,test;Directed Molecular Evolution;Disease;disorder control;Electron Transport;Engineered Probiotics;Engineering;Ensure;Environment;Enzymes;Epithelium;Equilibrium;Escherichia coli;Gel;Genetic;genotoxicity;gut microbiota;Health;high reward;high risk;Human;human tissue;Hydrogen Sulfide;In Situ;In Vitro;Individual;Inflammation;inflammatory marker;Integration Host Factors;interest;Intestines;Kinetics;Link;Logic;mathematical model;Measurement;Metabolic Pathway;Metabolism;Microbe;microbial;Mitochondria;Modality;Modeling;mucosal microbiota;Mucous body substance;Mucous Membrane;novel;novel therapeutics;operation;Organ;Output;oxidation;Oxygen;Pathway interactions;Patients;Performance;Physiological;Physiology;Play;Probiotics;Production;promoter;Property;Publishing;Reactive Oxygen Species;Research;Resolution;response;Rheology;Role;sensor;small molecule;spatiotemporal;Structure;Sulfides;synthetic biology;System;Technology;Therapeutic;therapy outcome;Thick;transcription factor;Transcriptional Regulation;Tube;Ulcerative Colitis;Validation;Work

PROJECT_TITLE: Engineered Probiotics for Closed-Loop Control of Disease-Associated Gut Metabolites in Gut-On-Chip Models

STUDY_SECTION: CMT

STUDY_SECTION_NAME: Cellular and Molecular Technologies Study Section[CMT]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cardiovascular;Clinical Research;Heart Disease;Organ Transplantation;Pediatric;Prevention;Transplantation

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PROJECT NARRATIVE Acute rejection remains a major cause of morbidity and mortality in pediatric patients after heart transplant. In order to screen for rejection, most centers perform heart catheterizations with endomyocardial biopsies frequently in the first year post transplant and then every 1-2 years thereafter; these biopsies are associated with complications, can cause significant anxiety in patients and family members, and are a significant cost for the healthcare system. This project will evaluate non-invasive methods of detecting rejection using cardiac magnetic resonance imaging and blood testing with a goal to reduce the required number of cardiac catheterizations.

PI_NAMEs: DAMON, BRUCE M.;SAMYN, MARGARET MARY;SOSLOW, JONATHAN HARVEY (contact)

PROGRAM_OFFICER_NAME: BURNS, KRISTIN

PROJECT_TERMS: Acute;Address;Adoption;Algorithms;anesthesia complication;Anxiety;Biological Markers;Biopsy;Blood;Blood Tests;Blood Vessels;Cardiac;Cardiac Catheterization Procedures;cardiac magnetic resonance imaging;Cardiomyopathies;Cardiovascular system;Caring;Catheterization;Cause of Death;Cell Fraction;cell free DNA;Child health care;Childhood;Clinical;clinical decision-making;clinical practice;Clinical Trials;Collaborations;Complication;coronary fibrosis;cost;Cost Analysis;cost efficient;Data;detection method;Diagnosis;Disease;Edema;Eligibility Determination;Ensure;Exclusion;extracellular;Family member;Frequencies;Goals;graft dysfunction;Grant;Health Care Costs;Healthcare Systems;Heart Transplantation;Histologic;Image;Image Analysis;imaging scientist;imaging study;Immunosuppression;Impairment;improved;Inflammation;Injury;innovation;insight;interest;Left;Magnetic Resonance;magnetic resonance imaging biomarker;Maps;Measurement;Measures;Methods;MicroRNAs;Modeling;Morbidity - disease rate;mortality;Multicenter Studies;Myocardial;Myocardium;Non-Invasive Detection;parametric imaging;Pathologic;Patients;Pattern;pediatric patients;Pediatric Research;Perforation;Physiological;Population;post-transplant;predictive modeling;Predictive Value;Preparation;Probability;Property;prospective;Quality of life;Radiation;Resolution;Risk;Risk Reduction;Sampling;screening;Sedation procedure;Severities;Societies;Specificity;standard of care;System;Testing;Texture;Tissues;Transplant Recipients;United States;Ventricular;Work

PROJECT_TITLE: Predictive modeling of acute rejection in pediatric heart transplant recipients

STUDY_SECTION: CHSB

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology B Study Section[CHSB]


ADMINISTERING_IC: TW

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Depression;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Pediatric;Pediatric - AIDS;Prevention;Social Determinants of Health;Violence Research;Youth Violence

ORG_CITY: BALTIMORE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE The proposed study will address the intersecting stigmas of HIV, violence and depression among adolescents and young adults (15-24) living with HIV (AYALHIV) in Zambia. The study will integrate a problem management-based mental health approach into an existing HIV-stigma-reducing intervention, and refine measures of internalized and intersecting stigmas, to create and test the feasibility of Project YES+- a combined youth peer mentoring and lay mental health intervention. This research aims to shift HIV care and treatment for AYALHIV by addressing the multiple internalized and intersecting stigmas that impeded antiretroviral adherence and HIV viral suppression.

PI_NAMEs: DENISON, JULIE ANNE (contact)

PROGRAM_OFFICER_NAME: BANSAL, GEETHA PARTHASARATHY

PROJECT_TERMS: 19 year old;acceptability and feasibility;Address;Adherence;Adolescence;Adolescent;Adolescent and Young Adult;Adolescent Health Services;Adult;Africa South of the Sahara;Age;age group;AIDS prevention;Anti-Retroviral Agents;antiretroviral therapy;Anxiety;anxiety symptoms;Caring;Cause of Death;Childhood;Chronic Disease;Clinic;Cognitive;cognitive interview;Complex;Data;Data Collection;depressive symptoms;design;Development;emotional abuse;Emotions;Ensure;Evidence based intervention;experience;Failure;feasibility testing;Feeling;Frequencies;Future;Goals;Guilt;Health;health training;HIV;HIV/AIDS;improved;internalized stigma;Interruption;Intervention;Link;Literature;low and middle-income countries;Measurement;Measures;medication compliance;Mental Depression;Mental Health;Mentors;Odds Ratio;Outcome;Participant;Pathway interactions;Pediatric Hospitals;peer;peer coaching;PF4 Gene;Population;Process;programs;psychologic;psychological violence;Randomized;Randomized, Controlled Trials;reduce symptoms;Research;response;Risk;Services;sexual violence;Shame;skills;social;Social Identification;social stigma;South African;standard of care;success;System;systematic review;Testing;Thailand;therapy adherence;transition to adulthood;United States National Institutes of Health;Victimization;Violence;violence victimization;Viral;Viral Load result;World Health Organization;Youth;Zambia

PROJECT_TITLE: Reducing the intersecting stigmas of HIV, violence victimization, and mental health: a randomized controlled pilot integrating Project YES! Youth Engaging for Success and Problem Management Plus amon

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;HIV/AIDS;Infectious Diseases;Liver Disease

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: 8. NARRATIVE In this application, we propose to determine the effect of the newly identified neutrophil subpopulations on the progression of liver and gastrointestinal disease in ART-treated HIV-1-infected individuals. Since functional dysregulation of the neutrophil population and its impact on the innate immune balance can be pharmacologically targeted, understanding the underlying pathogenic mechanisms will lead to novel treatment approaches in HIV-1 infection and other chronic inflammatory conditions.

PI_NAMEs: HEL, ZDENEK  (contact)

PROGRAM_OFFICER_NAME: DOO, EDWARD

PROJECT_TERMS: Adult;Animal Model;Anti-Inflammatory Agents;Automobile Driving;Bacteria;Bacterial Infections;Biopsy;Blood Circulation;Cause of Death;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Chronic;Circulation;comorbidity;Data;Disease;Disease Progression;Enrollment;Epithelium;Equilibrium;Exhibits;extracellular;firewall;Frequencies;gastrointestinal;Gastrointestinal Diseases;gastrointestinal epithelium;Gastrointestinal tract structure;Gene Expression Profile;Genes;Gut associated lymphoid tissue;Hepatitis C virus;HIV-1;IL17 gene;Immune;immune activation;Impairment;Individual;Infection;Inflammation;Inflammatory;Interferons;Intervention;Intestinal permeability;Kupffer Cells;Liver;Liver diseases;Liver Fibrosis;liver injury;Macrophage;Mediating;Methods;microbial;monocyte;Morbidity - disease rate;mortality;Mucous Membrane;NADPH Oxidase;neutrophil;Neutrophil Activation;Neutrophil Infiltration;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;novel;Pathogenesis;Pathogenicity;Pathologic;Pathway interactions;Patients;Permeability;Persons;pharmacologic;Phenotype;Play;Population;predictive marker;Prevalence;Property;Publishing;Reactive Oxygen Species;Reporting;Research;response;Role;Secondary to;Severity of illness;Structural defect;Testing;Tight Junctions;Tissues

PROJECT_TITLE: Dysregulated neutrophil subpopulations as a driving mechanism of liver and gastrointestinal disease in HIV-1-infected individuals

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cardiovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: Oakland

ORG_NAME: KAISER FOUNDATION RESEARCH INSTITUTE

PHR: PROJECT NARRATIVE People released from prison suffer poor cardiovascular health, high rates of cardiovascular mortality, and other health problems. We propose to examine organizational policies and practices in healthcare systems that affect people’s access to quality healthcare after release from prison. This project will assist healthcare systems and other organizations in addressing the health care gap for people released from prison.

PI_NAMEs: DAUGHERTY, STACIE LUTHER (contact)

PROGRAM_OFFICER_NAME: COADY, SEAN

PROJECT_TERMS: access disparities;Address;Adult;Affect;Area;Attitude;behavioral health;Black Populations;Black race;Cardiology;Cardiovascular Diseases;cardiovascular health;cardiovascular risk factor;Cardiovascular system;care outcomes;Clinic Visits;cohort;Colorado;Communities;community academic partnership;community advisory board;community organizations;Criminal Justice;Data;Databases;Disadvantaged;Discrimination;Eligibility Determination;Emergency Situation;Employment;Enrollment;Ethnic Origin;Event;Exposure to;Face;Focus Groups;follow-up;Frontline worker;Future;General Population;Goals;Health;health assessment;health care availability;health care quality;health care service organization;health care service utilization;health disparity;Health Services Accessibility;Health system;Healthcare;Healthcare Systems;High Prevalence;Hospitalization;Housing;housing instability;Imprisonment;Improve Access;improved;Indigenous;Individual;innovation;Intervention;Interview;Investigation;Link;Longitudinal cohort study;Measures;Medicaid;mortality;multidisciplinary;Observation in research;Organizational Policy;Outcome;Patients;peer;people of color;Persons;Policies;poor health outcome;Population;prevent;primary outcome;Prisons;Procedures;programs;prospective;Race;racial disparity;racism;Recommendation;Recording of previous events;Research;Research Methodology;safety net;secondary outcome;segregation;Services;social health determinants;social stigma;Structural Racism;System;Testing;Visit;Writing

PROJECT_TITLE: Healthcare Organizational Structural Conditions and the Health of People Recently Released from Prison


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Eye Disease and Disorders of Vision;Rare Diseases

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: DUKE UNIVERSITY

PHR: PROJECT NARRATIVE Meibomian gland dysfunction, a disorder of the oil glands situated in the eyelid, is the leading cause of dry eye disease and the most common reason for patients seeking professional eyecare in the U.S. Yet there are no FDA approved medicines for this condition. The focus of this grant is to understand how inflammation of the eyelid and surrounding eye tissues, which is typically accompanied by Meibomian gland dysfunction, contribute to this condition and thereby will lay the groundwork for future identification of new drug targets.

PI_NAMEs: SABAN, DANIEL RAPHAEL (contact)

PROGRAM_OFFICER_NAME: MCKIE, GEORGE ANN

PROJECT_TERMS: Ablation;Aging;Allergic;Atlases;atopy;Automobile Driving;Benign Mucous Membrane Pemphigoid;Bioinformatics;Blood;Caring;Cells;chemokine receptor;Chronic;Clinical;Color;Complex;conjunctiva;Cutaneous;Data;Data Set;Diagnosis;diagnostic biomarker;Disease;disease model;Dry Eye Syndromes;Duct (organ) structure;Epithelium;evaporation;Eye;Eye diseases;eye dryness;Eyelid structure;FDA approved;Film;Flow Cytometry;Funding;Future;Genes;Genetic;Genetic Models;genome wide association study;Gland;graft vs host disease;Grant;Human;human disease;Hypersensitivity;Image;Immune;Immune response;Immune System Diseases;Immunodiagnostics;Immunologic Markers;in vivo;Individual;Inflammation;Kinetics;Knowledge;Link;Lipids;Literature;Maps;Mediating;Medicine;meibomian gland dysfunction;Metadata;Microscopy;Mind;Modeling;mouse model;Mucous Membrane;Mus;Mutagenesis;neutrophil;Neutrophil Infiltration;new therapeutic target;novel;novel therapeutic intervention;Obstruction;Ocular cicatricial pemphigoid;ocular surface;ocular surface disease;Oils;Outcome Study;overexpression;Pathogenesis;Pathogenicity;Pathologic;Pathologic Processes;Pathology;Patients;pharmacologic;Phenotype;Play;Prevalence;Process;programs;Risk Factors;Role;Sampling;Sebaceous Glands;Severities;single-cell RNA sequencing;Sjogren's Syndrome;Skin;Stevens-Johnson Syndrome;Surface;Tissues;tool;Toxic Epidermal Necrolysis;Translating;tv watching;Work;Zinc Fingers

PROJECT_TITLE: Defining the Immune Cell Roles in Meibomian Gland Dysfunction in the Context of Ocular Surface Immune Diseases

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 1 Study Section[PED1]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Prevention;Social Determinants of Health

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: Public Health Relevance Statement Ending the HIV epidemic in America will require effective delivery of treatment to all people living with HIV. Low-barrier care improves access to HIV treatment for people with complex medical and social needs who have not done well with regular medical care. We will study the expansion of low-barrier care in Seattle/King County, Washington and prepare for scale-up of low-barrier care in other parts of the United States.

PI_NAMEs: DOMBROWSKI, JULIA COOK (contact)

PROGRAM_OFFICER_NAME: POLLARD-BRANCHARD, SUZANNE LEE

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Assessment tool;barrier to care;care coordination;Caring;Cities;Clinic;Clinic Visits;cohort;Cohort Studies;Collaborations;community organizations;Complex;cost;Country;County;Data;design;Education;Effectiveness;Electronic Health Record;Enrollment;Epidemic;epidemic preparedness;Equation;evidence base;Evidence based intervention;Focus Groups;Funding;Goals;Health;health care service organization;HIV;HIV diagnosis;housing instability;implementation strategy;Improve Access;improved;Incentives;Individual;informant;Intervention;Interview;Investigation;Maintenance;Measures;Medical;Mental disorders;Methods;microcosting;Modification;multi-component intervention;Neighborhood Health Center;Outcome;Persons;Phase;Policies;Population;population based;Primary Care;programs;prospective;Public Health;public health relevance;Reach, Effectiveness, Adoption, Implementation, and Maintenance;recruit;Reporting;Research;scale up;secondary analysis;service coordination;social;social health determinants;Structure;substance use;surveillance data;Territoriality;tool;United States;Universities;Viral;Viral Load result;Viremia;Vulnerable Populations;Walking;Washington;Work

PROJECT_TITLE: Scaling Low-Barrier Care to Engage People with Complex Needs in HIV Treatment


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Despite a heightened focus on patient safety over the past two decades, preventable harms remain excessively high with implications for mortality, morbidity, and quality of life. This innovative health services research training program focuses on patient safety in the hospital setting, with direct application to policy and patient care. This interdisciplinary postdoctoral research training program will prepare the next generation of diverse health services researchers to generate evidence to improve safety, quality, equity, and outcomes in healthcare delivery.

PI_NAMEs: ADELMAN, JASON STUART (contact);BARR, R GRAHAM

PROGRAM_OFFICER_NAME: DESOTO, MAUSHAMI

PROJECT_TITLE: Patient Safety and Health Services Research Training


ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE COVID-19 has highlighted many of the finest and poorest aspects of the U.S. health care system - new vaccines were developed and delivered in record time through joint public-private partnerships, but there have been huge inequities in hospitalization and mortality rates among racial minoritized groups. The pandemic also highlighted a lack of preparedness: having a sufficient number of well-trained public health workers who can be mobilized on short notice as well as a sufficient stockpile of equipment such as surgical-quality masks. The proposed training program will make significant and distinctive contributions to the field by shepherding new scholars who will work in academia, research organizations, health care delivery systems and industry research groups to address this and many other of the country’s ongoing health and healthcare challenges.

PI_NAMEs: EISENBERG, DANIEL  (contact)

PROJECT_TITLE: Los Angeles Area Health Services Research Training Program


ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: Project Narrative The US health care system is rapidly transforming in response to social, economic and policy changes and requires timely research designed to be informative to and actionable by health care professionals, delivery systems, policymakers, and the public. Skilled researchers are needed to assist in these changes so as to maximize the quality, equity, and efficiency of clinical care delivery, and to address current disparities in health and health care. The Sheps Center at UNC Chapel Hill proposes to train PhD and clinical investigators in the methods of health services research toward those goals.

PI_NAMEs: HOLMES, GEORGE M (contact)

PROGRAM_OFFICER_NAME: CHANLONGBUTRA, AMORNRAT

PROJECT_TITLE: UNC-CH Training Program in Health Services Research


ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE The University of Chicago And Northwestern University Predoctoral Health Services Research Program, referred to as the “UCANU Predoctoral HSR Program,” proposes to build and expand upon the first ten years of success of a unique, joint predoctoral training program to prepare social scientists and clinicians with the knowledge and methodological skills to address the most pressing issues in the US healthcare delivery system.

PI_NAMEs: KONETZKA, RITA TAMARA (contact);MELTZER, DAVID O

PROGRAM_OFFICER_NAME: WILLIS, TAMARA

PROJECT_TITLE: The University of Chicago and Northwestern University Predoctoral Health Services Research Program-Renewal


NIH_SPENDING_CATS: Clinical Research;Hematology;Infectious Diseases;Kidney Disease;Pediatric;Precision Medicine;Sepsis

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: PROJECT NARRATIVE Despite years of research, morbidity and mortality from pediatric septic shock remains unacceptably high, particularly in children who develop acute kidney injury. The heterogeneity of sepsis (and, by extension, sepsis- associated acute kidney injury) dictates that precision medicine approaches to diagnosis and management are sorely needed to identify effective therapies and improve outcomes in these children. As such, this proposal seeks to leverage large-scale clinical and biomarker data to better characterize sepsis-associated acute kidney injury through the identification of novel subphenotypes for prognostic and predictive enrichment, and identify strategies for successful implementation of personalized approaches to care at the bedside.

PI_NAMEs: STANSKI, NATALJA L. (contact)

PROGRAM_OFFICER_NAME: BLATCH, SYDELLA ANNE

PROJECT_TERMS: Acute Renal Failure with Renal Papillary Necrosis;Address;Admission activity;Adoption;Adult;Affect;Algorithms;Angiotensin II;Area;Award;beta-Chemokines;biobank;Biological Markers;Biology;biomarker signature;Biometry;career development;Caring;Categories;Child;Childhood;Clinical;Clinical Data;Clinical Trials;Cluster Analysis;cohort;college;Consensus;Convulsive therapy;Critical Care;Critical Illness;Critically ill children;Data;Data Set;Databases;design;Development;Development Plans;Diagnosis;Disease;Disease Outcome;effective therapy;experience;Failure;Foundations;Future;Goals;Granzyme;Heat shock proteins;Heterogeneity;high risk;Immune response;implementation science;improved outcome;Incidence;Infection;Inflammatory;Interleukin-8;Intervention;Knowledge;Ligands;Literature;Maintenance;Maps;Measures;Medical center;Medicine;Mentors;Mentorship;Metalloproteases;Methodology;Morbidity - disease rate;mortality;mortality risk;Nature;new therapeutic target;novel;Observational Study;Outcome;patient oriented;patient oriented research;patient subsets;Patients;Pediatric Hospitals;Pediatric Intensive Care Units;pediatric sepsis;personalized approach;personalized management;Pharmaceutical Preparations;Phenotype;phenotypic data;Physicians;Positioning Attribute;precision medicine;Prediction of Response to Therapy;Process;professor;Prognosis;prognostic;prospective;Qualitative Research;Recommendation;Renal Replacement Therapy;Renin;Research;Research Infrastructure;Research Methodology;Research Personnel;Residual state;response;Scientist;Sepsis;Septic Shock;Serum;Severity of illness;Subgroup;success;Supportive care;Syndrome;Techniques;theories;therapy outcome;Training;transcriptomics;translational scientist;treatment strategy;Universities;Validation;vasoactive agent;Vasopressins;Work

PROJECT_TITLE: Developing a Precision Medicine Approach to Pediatric Sepsis-Associated Acute Kidney Injury: Identification of Unique Subphenotypes and Strategies for Bedside Implementation

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

ORG_CITY: ROCHESTER

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: PROJECT NARRATIVE Electrical microstimulation may prove to be a useful technique for delivering information from neuroprosthetic devices to the cerebral cortex. Current efforts to understand how the brain uses such information have focused on the effects of stimulation on nerve cells in close proximity to the electrode tip, though electrical stimulation may influence neural activity far from the stimulation site. The proposed studies will test the hypothesis that electrical stimulation affects nerve cells in distant cortical areas as the brain learns to interpret the stimulation and quantify how those effects evolve over time with training, which will provide insights for improving the utility of electrical stimulation in neuroprosthetic devices.

PI_NAMEs: RUSZALA, BRANDON MICHAEL (contact)

PROGRAM_OFFICER_NAME: CHEN, DAOFEN

PROJECT_TERMS: Affect;Anterior;Area;Auditory;Automobile Driving;Brain;brain machine interface;Brain region;Central Nervous System;Cerebral cortex;Cochlear Implants;Cognitive;Cohort Studies;Craniocerebral Trauma;Cues;Data Analyses;Data Set;design;Devices;Distal;Distant;Dorsal;Electric Stimulation;electrical microstimulation;Electrodes;Exhibits;experimental study;Feedback;Fire - disasters;Forelimb;gray matter;Implant;improved;insight;Instruction;Knowledge;Laboratories;Learning;meter;Microelectrodes;microstimulation;Modality;Monkeys;Motor;motor control;Motor Cortex;Motor Neurons;Movement;Muscle;Nervous System Disorder;neural;Neuronal Plasticity;Neurons;neuroprosthesis;Outcome;Parietal;Parietal Lobe;Patients;Pattern;Performance;Physiologic pulse;Positioning Attribute;prevent;Process;Protocols documentation;Radial;Records;Sensory;sensory cortex;sensory neuropathy;simulation;Site;somatosensory;Somatosensory Cortex;Spinal;Stimulus;Stroke;success;Synapses;Techniques;Technology;Testing;Time;Training;Translating;Upper Extremity;Visual;Work

PROJECT_TITLE: Effects of Intracortical Microstimulation on Neural Activity in Distant Cortical Regions


NIH_SPENDING_CATS: Aging;Cardiovascular;Clinical Research;Contraception/Reproduction;Genetics;Heart Disease;Maternal Health;Maternal Morbidity and Mortality;Pregnancy;Rare Diseases;Women's Health Research

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE The proposed research seeks to elucidate the role of placental senescence in peripartum cardiomyopathy (PPCM). This research plan is relevant to public health because it is expected to provide fundamental insights into the underlying pathophysiological mechanisms driving PPCM, a leading cause of maternal heart failure. Thus, it accomplishes the NIH and NHLBI’s missions and initiatives by not only providing novel insights into our understanding of the biology underlying cardiovascular disease, but also potential therapeutic advancements that could improve the longevity and health of individuals afflicted with heart disease.

PI_NAMEs: ROH, JASON DAVID (contact)

PROGRAM_OFFICER_NAME: DESVIGNE-NICKENS, PATRICE

PROJECT_TERMS: Acceleration;activin A;age acceleration;Aging;aging biomarker;Automobile Driving;Biological;Biological Models;Biological Process;Biology;Biology of Aging;Cardiac;Cardiac Myocytes;Cardiovascular Diseases;Cardiovascular Physiology;case control;Cells;Clinical;Coculture Techniques;cohort;Data;Development;Disease;Etiology;Experimental Models;experimental study;Functional disorder;gain of function;Genetic;Genetic Predisposition to Disease;Health;Heart;Heart Diseases;Heart failure;heart function;hemodynamics;Human;Human body;human genomics;Hypertrophy;implantation;improved;in vitro Model;in vivo;Incidence;Individual;Infection;innovation;insight;Intervention;Late pregnancy;life span;Longevity;loss of function;Malignant Neoplasms;Metabolic;metabolic phenotype;Mission;Modeling;Mus;Myocardial dysfunction;National Heart, Lung, and Blood Institute;novel;Organ;Parabiosis;paracrine;Pathogenesis;Pathologic;Pathway interactions;peripartum cardiomyopathy;pharmacologic;Phenotype;Placenta;Postpartum Period;Pre-Clinical Model;Pre-Eclampsia;Pregnancy;Process;Proteins;Proteome;Proteomics;Public Health;Research;research study;Risk Factors;Role;secretory protein;senescence;senescence associated secretory phenotype;senolytics;Serum;Severities;Study models;Syndrome;System;targeted treatment;Technology;Therapeutic;therapeutic development;Tissues;transcriptome sequencing;translational potential;United States National Institutes of Health;Ventricular Remodeling;Woman;Women's study;Work;young woman

PROJECT_TITLE: Placental Senescence in Peripartum Cardiomyopathy

STUDY_SECTION: MPPA

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology A Study Section [MPPA]


NIH_SPENDING_CATS: Behavioral and Social Science;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Lung;Neurosciences;Opioids;Pain Research;Sleep Research

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative Opioid use has greatly increased in recent decades and has been characterized as a public health crisis. Even amongst those using prescription opioids under physician supervision for chronic pain, these medications may lead to adverse effects, potentially by contributing to breathing issues during sleep. The goal of this research is to understand how these breathing issues might affect patients using opioids, as well as to help identify treatments that will improve symptoms and potentially decrease the risk of poor health outcomes.

PI_NAMEs: ORR, JEREMY ELLIOT (contact)

PROGRAM_OFFICER_NAME: LAPOSKY, AARON D

PROJECT_TERMS: Acetazolamide;Address;Adverse effects;adverse outcome;Affect;American;Apnea;Ataxia;Award;Breathing;Brief Pain Inventory;California;career development;Caring;Central Sleep Apnea;Chest;Chronic;chronic pain;chronic pain patient;Clinical Research;Clinical Trials;comorbidity;comparative effectiveness;Complex;Continuous Positive Airway Pressure;Critical Care;Cross-Over Trials;Data;Development Plans;Disease;Doctor of Medicine;Dose;efficacy evaluation;Event;Excess Mortality;Faculty;Failure;Fellowship;Foundations;Funding;Goals;Health;high risk population;Hypoventilation;Impairment;improved;improvement on sleep;indexing;Individual;individualized medicine;Knowledge;Laboratories;Link;Measures;Mediating;Medical;Medicine;member;Mentored Patient-Oriented Research Career Development Award;Mentors;Moods;Morbidity - disease rate;mortality;mortality risk;National Research Service Awards;Opioid;opioid use;opioid user;Overdose;Oxygen;Pain;Pathogenesis;patient oriented;Patients;patients who use opioids;Persistent pain;personalized approach;Pharmaceutical Preparations;Pharmacotherapy;Physicians;Physiology;Placebos;Polysomnography;poor health outcome;poor sleep;prescription opioid;primary outcome;professor;prospective;Public Health;public health emergency;Pulmonology;Quality of life;Randomized;randomized trial;Recreation;Research;research and development;Research Personnel;Research Support;Respiration Disorders;respiratory;Respiratory physiology;Risk;Science;Scientist;secondary outcome;Signal Transduction;Sleep;Sleep Apnea Syndromes;Sleep disturbances;sleep physiology;sleep quality;sleep regulation;Societies;Specialist;statistics;Supervision;symptomatic improvement;Symptoms;Techniques;treatment as usual;Treatment Failure;treatment risk;treatment strategy;trial design;United States Dept. of Health and Human Services;United States National Institutes of Health;Universities;ventilation

PROJECT_TITLE: The Impact of Sleep Disordered Breathing in People who use Opioids

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(OA)]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases;Rare Diseases;Tuberculosis

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: NARRATIVE Mycobacterium tuberculosis (Mtb) is the second leading cause of death from infection today after COVID-19. Mtb’s fate in the host is largely controlled by host cells called macrophages, but Mtb eventually kills the macrophages in which it resides and goes on to infect more macrophages. Surprisingly, the Mtb-infected macrophage participates in its own death by responding to its own interferon-beta, and this proposal aims to find out how, so that future studies might develop drugs that help macrophages better control tuberculosis.

PI_NAMEs: NATHAN, CARL FRANCIS (contact)

PROGRAM_OFFICER_NAME: EICHELBERG, KATRIN

PROJECT_TERMS: Aconitic Acid;Animal Model;Antibiotics;Antimycobacterial Agents;Apoptosis;bactericide;Binding;Biochemical;Biogenesis;candidate identification;candidate validation;Carboxy-Lyases;Cathepsins;Cause of Death;Cell Death;Cell Death Induction;Cell Line;Cells;Cessation of life;Chemicals;Cods;COVID-19;CRISPR-mediated transcriptional activation;cytokine;Drug resistance;drug-like compound;Enzymes;experimental study;Future;G-Protein-Coupled Receptors;gene product;Genes;Genetic;genetic approach;Goals;GPR84 gene;Growth;IFNAR1 gene;Immune Response Genes;Impairment;improved;In Vitro;Individual;Infection;Inflammation;inhibitor;innovation;Interferon alpha;Interferon Type I;Interferon-beta;Learning;Link;lysosomal Pro-X carboxypeptidase;Lysosomes;Macrophage;Mediating;Medium chain fatty acid;Molecular;Monoclonal Antibodies;Mus;Mycobacterium tuberculosis;Necrotic Lesion;Orphan;overexpression;Participant;pathogen;Pathology;Pathway interactions;Peptide Hydrolases;Pharmaceutical Preparations;Pre-Clinical Model;Process;Proteins;receptor;Regimen;Resistance;response;Role;Signal Transduction;Speed;success;Testing;transcription factor;Tuberculosis;tuberculosis treatment;type I interferon receptor;Virulent;Virus

PROJECT_TITLE: Mechanisms of macrophage death co-dependent on M. tuberculosis and IFN-a,b receptor

STUDY_SECTION: BHI

STUDY_SECTION_NAME: Bacterial-Host Interactions Study Section [BHI]


NIH_SPENDING_CATS: Cardiovascular;Genetics;Heart Disease

ORG_CITY: DUARTE

ORG_NAME: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE

PHR: Project Narrative  Heart failure is a leading cause of death worldwide. Pathological cardiac remodeling in response to hypertension induces the unfolded protein response in cardiomyocytes, of which precise roles and mechanisms- of-action are elusive. Experiments laid out here will focus on a novel function of the unfolded protein response in pressure overload-induced cardiomyopathy and heart failure, which may provide new insights for our understanding of hypertensive heart disease and shed light on novel therapeutic approaches.

PI_NAMEs: WANG, ZHAO  (contact)

PROGRAM_OFFICER_NAME: TJURMINA, OLGA A

PROJECT_TERMS: Acute;Age;Anabolism;arm;ATF6 gene;Automobile Driving;Binding;Biological Assay;Cardiac;Cardiac Myocytes;Cardiomyopathies;cardioprotection;Cause of Death;cell growth;Collaborations;combat;Complex;conditional knockout;Consensus;Data;Defect;design;Development;Enzymes;Epidermal Growth Factor Receptor;Event;experimental study;Functional disorder;Funding;gain of function;Genetic Transcription;Goals;Growth;Heart;Heart failure;Heart Hypertrophy;hemodynamics;Hexosamines;Hypertension;hypertensive heart disease;in vivo;Inflammation;Inositol;insight;interest;knock-down;knockout animal;Knockout Mice;loss of function;Mass Spectrum Analysis;Mediating;Medical center;Membrane;Membrane Proteins;Messenger RNA;Metabolic;Molecular;molecular marker;Morbidity - disease rate;mortality;mouse model;multidisciplinary;Muscle Cells;novel;novel therapeutic intervention;Outcome;Pathologic;Physiologic pulse;pressure;Process;programs;Protein Biosynthesis;protein folding;Proteins;Proteomics;Reaction;receptor;Reporting;Research;response;restoration;ribosome profiling;Risk Factors;RNA Splicing;Role;screening;Signal Pathway;Signal Transduction;Stimulus;Stress;Structure;Testing;therapeutic target;therapeutically effective;transcription factor;transcriptome sequencing;Transducers;Transgenic Mice;Translation Initiation;Translational Regulation;Translations;Untranslated Regions;Validation;XBP1 gene

PROJECT_TITLE: Role of the unfolded protein response in pathological cardiac remodeling


NIH_SPENDING_CATS: Biomedical Imaging;Clinical Research;Digestive Diseases;Nutrition;Pediatric;Prevention

PHR: PROJECT NARRATIVE Exocrine pancreatic insufficiency (EPI), the result of inadequate secretion of digestive juice from the pancreas, results from multiple diseases including chronic pancreatitis (CP) and can have serious effects in children including malnutrition and growth failure. Unfortunately, accurate diagnosis of EPI requires invasive testing under anesthesia, and prediction of progression to CP and EPI is not currently possible. We propose to develop accurate, non-invasive imaging methods to diagnose EPI and predict progression to CP to allow early and effective intervention and improved management of pediatric pancreatic disease.

PI_NAMEs: TROUT, ANDREW TIMOTHY (contact)

PROGRAM_OFFICER_NAME: UNALP-ARIDA, AYNUR

PROJECT_TERMS: 3-Dimensional;accurate diagnosis;Acute;acute pancreatitis;Anesthesia procedures;Atrophic;Benchmarking;Blood Glucose;Child;Childhood;chronic pancreatitis;clinical decision-making;Data;decision research;Detection;Development;Diagnosis;Diagnostic;diagnostic criteria;Digestion;Disease;Early Diagnosis;Early identification;Early Intervention;effective intervention;Elastases;Endocrine;Endoscopy;Enzymes;Exocrine pancreas;Exocrine pancreatic insufficiency;Failure;Fasting;Feces;Fibrosis;Fluids and Secretions;Future;gastrointestinal;Glycosylated hemoglobin A;Growth;Health;Human;Image;imaging modality;improved;Incidence;Intravenous;Laboratories;Link;Liquid substance;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Malabsorption Syndromes;Malnutrition;Manuals;Maps;Measurement;Measures;Modeling;non-invasive imaging;noninvasive diagnosis;Normal Range;novel;nutrition;Osteoporosis;Pancreas;Pancreatic Diseases;Pancreatic enzyme;Pancreatic Function Tests;pancreatic juice;Pancreatitis;Participant;Pathology;Patients;Performance;Procedures;Protocols documentation;Recording of previous events;recruit;Recurrence;Reference Standards;Relaxation;response;Scanning;Serum;Signal Transduction;Staging;Standardization;Structure;Techniques;Testing;Time;Tissues

PROJECT_TITLE: Multi-parametric quantitative MRI for assessment of pancreas health in children

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


ORG_CITY: NEW HAVEN

ORG_DEPT: PEDIATRICS

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative Endothelial cell (EC) alterations that occur in critically ill children can cause capillary leak with severe clinical consequences, but the mechanisms by which the capillary barrier becomes disrupted are unknown, limiting the development of effective therapies. We have identified changes in human ECs isolated from children presenting with multiple organ failures who later develop capillary leak associated with para- and transcellular leak and identified specific pharmacologic inhibitors. We will elucidate the mechanisms of these changes in appropriate culture models of human capillary ECs and validate our cell culture findings using an in vivo model of human skin capillaries implanted and perfused in immunodeficient mouse hosts in ex vivo perfused human lungs.

PI_NAMEs: PIERCE, RICHARD W (contact)

PROGRAM_OFFICER_NAME: GAO, YUNLING

PROJECT_TERMS: Acute;Adrenergic Agonists;Agonist;Antibodies;Area;Biological Assay;Blood;Blood capillaries;Blood Vessels;Body System;candidate identification;Capillary Endothelial Cell;Capillary Leak Syndrome;Cardiovascular system;Caring;Cell Culture Techniques;Cell Separation;Cells;Cessation of life;Child;Clinical;Clinical Trials;Complement;Confusion;Critical Illness;Critically ill children;cytokine;Data;Data Set;Dermal;Development;disability;effective therapy;Electrical Resistance;Endothelial Cells;Endothelium;Engineering;Equipment;ex vivo perfusion;Extravasation;FDA approved;Female;formoterol;Foundations;Functional disorder;Gene Expression;Gene Expression Profiling;Genes;Genetic Transcription;GTPase-Activating Proteins;Guanine Nucleotide Exchange Factors;Guanosine Triphosphate;Guanosine Triphosphate Phosphohydrolases;Health;Heart Arrest;Human;human disease;human model;Immunodeficient Mouse;Implant;improved;In Situ;In Vitro;in vivo;in vivo Model;Individual;Inflammatory;inhibitor;Investigation;JAK3 gene;Learning;Liquid substance;Lung;male;Mediating;Mediator;Modeling;Molecular;Molecular Target;monolayer;Morphology;Multiple Organ Failure;Mus;novel;oncostatin M;Organ;Organ failure;Pathway interactions;Patient-Focused Outcomes;Patients;Perfusion;pharmacologic;Phase;Phosphotransferases;Plasma;prevent;Process;Proteins;Regulation;Research;Respiratory Failure;response;Rest;Resuscitation;rho;rho GTP-Binding Proteins;Rodent Model;Sampling;Serum;Shock;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Skin;skin xenograft;STAT3 gene;Stereotyping;Supportive care;Surface;Synaptic Vesicles;Testing;therapeutic target;Tight Junctions;Time;Tissue Sample;TNF gene;TNFRSF1A gene;tool;Tracer;transcription factor;Vascular Endothelial Cell;Vesicle

PROJECT_TITLE: Molecular regulation of the capillary barrier in acute critical illness

STUDY_SECTION: IVPP

STUDY_SECTION_NAME: Integrative Vascular Physiology and Pathology Study Section[IVPP]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Drug Abuse (NIDA only);Neurodegenerative;Neurosciences;Sleep Research;Substance Misuse

ORG_DEPT: PSYCHOLOGY

PHR: PROJECT NARRATIVE The goal of this project is to address the crucial question of how reward-based memories are encoded in the brain. It will directly test the role of spontaneous reactivation of memory-relevant neurons distributed in multiple brain regions in memory formation and consolidation. These findings will be important not only for understanding the physiological basis of reward-based memories, but also relevant to human brain disorders such as addiction and Alzheimer’s disease.

PI_NAMEs: DRIEU, CELINE  (contact)

PROGRAM_OFFICER_NAME: BERTON, OLIVIER

PROJECT_TERMS: addiction;Address;Alzheimer's Disease;Animals;Area;arm;Auditory;Auditory area;awake;Binding;Brain;Brain Diseases;Brain region;career;cell assembly;Cells;Complex;Corpus striatum structure;Cues;density;Detection;Development;Disease;Dorsal;Educational process of instructing;Environment;Episodic memory;Event;Exhibits;experience;Fire - disasters;Fund Raising;Goals;Hippocampus;Human;in vivo;insight;Laboratories;Learning;learning outcome;Left;Location;Measures;Medial;Memory;memory consolidation;memory encoding;Memory impairment;memory process;Mentors;Mentorship;Methods;Modality;Motivation;neural;neural patterning;neuromechanism;Neuronal Plasticity;Neurons;neurophysiology;optogenetics;Outcome;Pathology;Pattern;Performance;Phase;Physiological;Play;Population;Prefrontal Cortex;Process;programs;Radial;Rattus;Reporting;Research;response;Response to stimulus physiology;Rest;Retrieval;Rewards;Role;Sensory;Site;skills;Sleep;spatial memory;Stimulus;Structure;support network;System;Testing;Time;Training;Work

PROJECT_TITLE: Role of multi-regional neuronal reactivations in reward-based memories


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Eating Disorders;Mental Health;Neurosciences;Nutrition;Obesity;Prevention

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE Binge eating is a maladaptive behavior widely present in the general population that is strongly associated with obesity risk. Loss of control over eating, a core diagnostic feature, is associated with difficulties disengaging from eating, and research examining feeding offset is needed to dissect circuit abnormalities. This project will characterize neural activity patterns contributing to feeding offset to ultimately develop improved treatments for aberrant eating contributing to obesity risk.

PI_NAMEs: HILDEBRANDT, BRITNY  (contact)

PROGRAM_OFFICER_NAME: CUMMINGS, DIANA M

PROJECT_TERMS: Acceleration;Acute;Animal Model;Area;Behavior;Behavior assessment;Behavior Control;behavior measurement;Behavioral;Behavioral Paradigm;Binge Eating;Calcium;career;cell type;Cells;Chronic;Clinical Research;Complex;Corpus striatum structure;Data;Development;Diagnostic;Eating;Eating Behavior;Ensure;Event;feeding;Feeding behaviors;Fiber;Food;Food Access;food consumption;Foundations;Future;General Population;Goals;Health;Hyperphagia;Image;Impairment;improved;in vivo;in vivo calcium imaging;Intervention;Investigation;Learning;Link;loss of control over eating;maladaptive behavior;Measurement;Mediating;Mediation;Medical;Mission;Morbidity - disease rate;mortality;Motor Cortex;Mus;neural;neural correlate;neuromechanism;Neurons;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;obesity risk;optogenetics;Pathologic;Pattern;Photometry;Physiological;Population;Pre-Clinical Model;prevent;programs;Protocols documentation;Public Health;Research;Resolution;Rewards;Role;Scientist;skills;Specificity;Statistical Data Interpretation;System;Technical Expertise;Techniques;Training;translational impact;Weight Gain;Work

PROJECT_TITLE: Dissecting circuits underlying loss of control relevant to binge eating

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


PHR: This proposed technology-development study will significantly advance quantitative acoustic microscopy (QAM) systems and ultimately pave the way towards wide acceptance of the technology. QAM systems permit formation of maps of the acoustical and mechanical properties of tissues at microscopic resolutions. Data-science methods and technological advances will be applied to make new, easy-to-use, low-cost, fine-resolution, QAM systems possible. Optimal methods will be incorporated in a prototype QAM (pQAM) instrument capable of producing images with ultra-fine spatial resolution (< 2 µm), much faster (<1 min), and at a much lower cost (<$40k) than current state-of-the-art QAM systems. In addition, pQAM use will be ``turn-key'' (i.e., requiring no technical knowledge and less than 1 hour of training.)

PI_NAMEs: MAMOU, JONATHAN  (contact)

PROGRAM_OFFICER_NAME: YEH, ALVIN TIEN-WEI

PROJECT_TERMS: Acoustic Microscopy;Acoustics;Biological;Biological Testing;Biomechanics;Cancer Patient;Cancerous;Clinical;clinical diagnostics;Code;Compensation;Computing Methodologies;cost;Data;data acquisition;Data Science;design;Development;Dictionary;Disease;Dyes;electric impedance;Electronics;Environment;expectation;experimental study;flexibility;Fostering;France;Frequencies;Generations;Goals;guinea pig model;Hour;Human;Image;image reconstruction;imaging modality;imaging properties;imaging system;Immunofluorescence Immunologic;improved;Industrialization;innovation;instrument;interest;Investigation;Knowledge;Laboratories;Laboratory Research;light microscopy;lymph nodes;Machine Learning;Maps;mechanical properties;meter;Methods;Microscope;Microscopic;microscopic imaging;Microscopy;Modality;Modeling;Modulus;Morphologic artifacts;Motor;Myopia;National Institute of General Medical Sciences;next generation;novel;novel strategies;Pathogenesis;Physics;Play;pre-clinical;prevent;Property;protein distribution;prototype;quantitative imaging;Relaxation;Research;Resolution;restoration;Sampling;Scanning;Sclera;Signal Transduction;simulation;sound;Specimen;Speed;Stains;Structure;success;System;Techniques;Technology;Technology Development Study;technology research and development;Testing;Thick;Thinness;Time;tissue mapping;Tissue Sample;Tissues;Training;ultra high resolution;Ultrafine;Ultrasonography;ultrasound;United Kingdom;Universities;user-friendly

PROJECT_TITLE: Next Generation Quantitative Acoustic Microscopy for Biomedical Application

STUDY_SECTION: ITD

STUDY_SECTION_NAME: Imaging Technology Development Study Section[ITD]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: NARRATIVE (OVERALL) The University of Michigan Rogel Cancer Center (Rogel) is committed to reducing cancer burden and improving cancer outcomes through research, innovation, transdisciplinary collaboration, education, and outreach. The Rogel vision is to be a leader in prevention, early diagnosis, optimal treatment and care for all at risk of or affected by cancer.

PI_NAMEs: FEARON, ERIC R. (contact)

PROGRAM_OFFICER_NAME: BELIN, PRECILLA L

PROJECT_TERMS: Abbreviations;Advanced Malignant Neoplasm;Advisory Committees;Affect;Animal Model;anti-cancer research;Appointment;Basic Science;Biological Sciences;Cancer Burden;Cancer Center;Cancer Center Support Grant;cancer clinical trial;Cancer Control;cancer education;cancer genetics;career;career development;Caring;Catchment Area;Cells;cellular imaging;Clinical;Clinical Research;Clinical Trials;Clinical Trials Support Unit;Collaborations;college;Communities;community advisory board;community center;community engagement;Community Outreach;Comprehensive Cancer Center;Data Science;Development;Developmental Therapeutics Program;Direct Costs;Doctor of Philosophy;Drug Kinetics;Drug Screening;Early Diagnosis;Education;Engineering;Epigenetic Process;epigenomics;equity, diversity, and inclusion;Faculty;Female;Financial Support;Flow Cytometry;Fostering;Funding;Gifts;Glossary;Grant;Growth;health communication;health equity;Health Policy;Hematopoiesis;Immunologic Monitoring;Immunology;improved;Infrastructure;innovation;Institution;inter-institutional;interdisciplinary collaboration;Intervention;Investments;irradiation;Journals;Justice;Leadership;liquid biopsy;Malignant Neoplasms;Manuscripts;medical schools;Medicine;member;Michigan;Mission;molecular imaging;molecular pathology;Names;National Cancer Institute;next generation;optimal treatments;Outcome;outreach;Patient Care;Patients;Population Sciences;pre-clinical;Prevention;Prevention program;programs;Proteomics;Public Health Schools;Publications;Publishing;Quality of life;Recording of previous events;recruit;Research;Resource Sharing;Resources;Risk;Role;Schools;Signal Transduction;Strategic Planning;Structure;Survivors;Tissue imaging;Tissues;Training;Training and Education;Transgenic Animals;Translational Research;translational research program;Translations;tumor microenvironment;United States National Institutes of Health;Universities;University of Michigan Comprehensive Cancer Center;Vision;Work

PROJECT_TITLE: University of Michigan Rogel Cancer Center Support Grant 2023-2028

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


NIH_SPENDING_CATS: Biotechnology;Cancer;Data Science;Prevention;Social Determinants of Health

PROJECT_TERMS: Affect;Animal Model;Appointment;Area;Cancer Burden;Cancer Center;Cancer Center Support Grant;Cancer Control;Cancer Family;cancer genetics;career development;Caring;Catchment Area;cellular imaging;Clinical;Clinical Research;Clinical Sciences;Collaborations;college;Committee Membership;Communities;community advisory board;community engagement;Community Outreach;Data Science;Dedications;Development;Developmental Therapeutics Program;diverse data;Drug Kinetics;Drug Screening;Early Diagnosis;Education;Ensure;Environment;equity, diversity, and inclusion;Evaluation;Evolution;Feedback;Five-Year Plans;flexibility;Flow Cytometry;Fostering;Glossary;Goals;health communication;health equity;Hematopoiesis;Immunologic Monitoring;Immunology;Infrastructure;innovation;interdisciplinary collaboration;Investments;irradiation;Justice;Laboratories;Leadership;Malignant Neoplasms;meetings;member;Michigan;Mission;molecular imaging;molecular pathology;multidisciplinary;Names;operation;optimal treatments;Patient Care;Patients;Pilot Projects;Population Sciences;Positioning Attribute;pre-clinical;Prevention;Process;Program Evaluation;programs;Proteomics;recruit;Research;Resource Allocation;Resource Sharing;Resources;response;Risk;Schools;Science;Services;Signal Transduction;single cell analysis;skills;Strategic Planning;Structure;success;Tissue imaging;Tissues;Training;Training and Education;Transgenic Animals;Translational Research;tumor microenvironment;Universities;University resources;Vision;working group

PROJECT_TITLE: Cancer Center Administration


NIH_SPENDING_CATS: Digestive Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: SEATTLE

PHR: PROJECT NARRATIVE Loss of intestinal homeostasis can occur in response to external stimuli such as allergens and worm parasites that cause Type 2 inflammation in the intestinal epithelium. Critically, bioactive lipid pathways are highly active in intestinal inflammation, but how these pathways control Type 2 inflammatory changes in the epithelium is unclear, representing a major gap in our understanding of how the intestine maintains homeostasis. Studies in this application will define how the lipid prostaglandin D2 and its receptor CRTH2 (chemoattractant receptor- homologous molecule expressed on Th2 cells) regulate intestinal epithelial biology during Type 2 inflammation to restore homeostasis, which will inform efforts to target prostaglandin pathways to treat intestinal diseases associated with a loss of homeostasis, including inflammatory bowel disease, cancer, and infection.

PI_NAMEs: TAIT WOJNO, ELIA D (contact)

PROGRAM_OFFICER_NAME: GREENWEL, PATRICIA

PROJECT_TERMS: Acute;Affect;Agonist;Allergens;antagonist;Biological;Biology;CCL4 gene;Cell Differentiation process;Cell Lineage;Cell Physiology;Cells;Chronic;cytokine;Data;Drug Targeting;Environment;Epigenetic Process;Epithelial Cells;epithelial stem cell;Epithelium;Event;Feedback;fMet-Leu-Phe receptor;Food Hypersensitivity;Gene Expression;Goblet Cells;gut homeostasis;gut inflammation;Health;helminth infection;Helminths;Homeostasis;Human;Hyperplasia;Hypersensitivity;Immune;Impairment;In Vitro;in vivo;Infection;Inflammation;Inflammatory;Inflammatory Bowel Diseases;inhibitor;Injury;Interleukin-13;intestinal barrier;Intestinal Diseases;intestinal epithelium;intestinal homeostasis;Intestinal permeability;Intestines;Knockout Mice;Laboratories;LGR5 gene;Lipids;Lung;Malignant Neoplasms;mast cell;Mediating;Morbidity - disease rate;Mus;novel;Parasites;Pathology;Pathway interactions;Patients;Permeability;Personal Satisfaction;Pharmaceutical Preparations;Physiological;Population;Positioning Attribute;prevent;programs;Prostaglandin D2;Prostaglandins;receptor;receptor expression;Recording of previous events;repaired;Reporter;Resolution;response;Role;Shapes;Single Nucleotide Polymorphism;Small Intestines;stem cell biology;stem cell differentiation;stem cell function;stem cell proliferation;Stimulus;Testing;Th2 Cells;Work

PROJECT_TITLE: Prostaglandin D2 and its receptor CRTH2 regulate intestinal inflammation and homeostasis

STUDY_SECTION: DHMI

STUDY_SECTION_NAME: Digestive System Host Defense, Microbial Interactions and Immune and Inflammatory Disease Study Section[DHMI]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: NEWMAN, ERIKA ADAMS (contact)

PROJECT_TERMS: Accountability;Address;Age;American Society of Clinical Oncology;Area;Award;Basic Science;Cancer Center;Cancer Center Support Grant;Cancer Control;cancer genetics;Cancer health equity;career development;Caring;Catchment Area;Climate;Clinical Research;Collection;college;Communities;community engagement;Community Outreach;community research;dashboard;Data Science;Databases;Developmental Therapeutics Program;Disability status;Discrimination;early-career faculty;Education;Education and Outreach;education research;Ensure;Environment;Equity;equity, diversity, and inclusion;Ethnic Origin;Evaluation;experience;Faculty;Faculty Recruitment;Fostering;Funding;Future;Gender;Gender Identity;Gifts;Glossary;Goals;harassment;health disparity;health equity;health equity promotion;Health equity research;Healthcare Systems;Hearing;Hematopoiesis;Home;Immunology;improved;Individual;Inequity;Infrastructure;Institution;Internships;Justice;K-12 student;Language;Leadership;leadership development;Lived experience;Malignant Neoplasms;Measures;member;Mentors;Mentorship;Michigan;Monitor;Names;National origin;Oncology;Outcome;outreach;Outreach Research;Pathway interactions;Patient Care;Patients;Personal Satisfaction;Persons;Politics;Population Sciences;Process;programs;Race;Rain;recruit;Religion;Research;research and development;Resource Sharing;Resources;Scholarship;Schools;Sex Orientation;Signal Transduction;Social Justice;Socioeconomic Status;Strategic Planning;Structure;Students;success;supportive environment;Surveys;System;Training;Training and Education;Translational Research;Trust;tumor microenvironment;unconscious bias;undergraduate student;Underrepresented Populations;Universities;Work

PROJECT_TITLE: Plan to Enhance Diversity