ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Data Science;Mental Health;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative We propose a renewal of support for the OpenNeuro data archive, which provides a platform for the storage, processing, and sharing of neuroimaging data collected as part of the BRAIN Initiative. OpenNeuro enables researchers to easily share a broad range of neuroscience data types, based on the Brain Imaging Data Structure standard for organizing datasets. Ongoing support for the platform as well as a set of improvements will sustain the success of the OpenNeuro archive and provide neuroscientists with increasingly usable data to address fundamental problems of brain function and health.

PI_NAMEs: POLDRACK, RUSSELL A (contact)

PROGRAM_OFFICER_NAME: JANES, DANIEL ERIC

PROJECT_TERMS: Address;Adoption;Agreement;Architecture;Archives;Brain;Brain imaging;BRAIN initiative;Client;Collaborations;Computer software;Custom;Data;data archive;data integration;data management;data modeling;data reuse;Data Set;data sharing;data structure;Databases;Dedications;Development;digital object identifier;distributed archives;Electroencephalography;Electromagnetics;Ensure;FAIR principles;flexibility;Funding;Funding Agency;Goals;Grant;Growth;Health;Human;human subject;improved;Informatics;Investments;Licensing;Link;Magnetic Resonance Imaging;Manuals;Measures;Metadata;Modality;neuroimaging;neurophysiology;Neurosciences;Neurosciences Research;Ontology;open data;Performance;permissiveness;Policies;Positron-Emission Tomography;Process;programs;Public Domains;Quality Control;Reporting;repository;Reproducibility;Request for Proposals;Research;Research Personnel;Retrieval;sharing platform;Side;Site;software development;Specific qualifier value;Standardization;Statistical Models;success;System;Testing;United States National Institutes of Health;usability;web site;Work

PROJECT_TITLE: OpenNeuro: An open archive for analysis and sharing of BRAIN Initiative data


ADMINISTERING_IC: NS

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: WASHINGTON

ORG_COUNTRY: UNITED STATES

ORG_DEPT: NEUROSCIENCES

ORG_FIPS: US

ORG_NAME: GEORGETOWN UNIVERSITY

ORG_STATE: DC

PHR: Project Narrative This research training program is focused on the scientific and professional development of advanced predoctoral thesis students in the area of neural injury and responses to injury. With respect to public health, this program will create a cadre of neuroscientists trained for research and/or management of research programs, through which new and more effective treatments for acute and degenerative disorders of the nervous system can be implemented.

PI_NAMEs: BURNS, MARK P;MAGUIRE-ZEISS, KATHLEEN ANNE (contact)

PROGRAM_OFFICER_NAME: WEIGAND, LETITIA ALEXIS

PROJECT_TERMS: nerve injury;Neuronal Plasticity

PROJECT_TITLE: Neural Injury & Plasticity


ADMINISTERING_IC: AI

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;Genetics;Infectious Diseases;Social Determinants of Health;Tickborne Diseases;Vector-Borne Diseases

ORG_CITY: HOUSTON

ORG_DEPT: PEDIATRICS

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: Project Narrative Relapsing fever spirochetes are a significant yet understudied disease impacting impoverished communities in low-income countries. Developing a cost effective and practical system to propagate relapsing fever spiro- chetes and study the pathogen’s transmission cycle is needed.

PI_NAMEs: LOPEZ, JOB E (contact)

PROGRAM_OFFICER_NAME: BOWDEN, NADINE

PROJECT_TERMS: Address;Asia;Bacteria;Bacterial Genome;Blood;Borrelia;chicken egg;Child;Chromosomes;Climate;Comparative Genomic Analysis;Complex;cost effective;Country;Data;Development;Disease;egg;epidemiology study;Gene Rearrangement;Genes;Genetic Recombination;Genome;genome annotation;genome resource;Genome Stability;genomic tools;Genomics;Goals;Growth;Health;improved;In Vitro;Knowledge;Life Cycle Stages;life span;Literature;low income country;Maintenance;Mammals;Middle East;model development;Modeling;Molecular;Molecular Probes;Morbidity - disease rate;mortality;Natural Source;neglect;novel;Order Spirochaetales;Ornithodoros;pathogen;pathogen genomics;Pathogenesis;Phylogenetic Analysis;Plasmids;Politics;poor communities;Positioning Attribute;Public Health;Publications;Publishing;Relapsing Fever;relapsing fever borrelia;Replicon;Reporting;Research;Resource-limited setting;Resources;Southern Blotting;System;Testing;tick bite;tick transmission;Ticks;Time;transmission process;Ukraine;vector;vector competence;vector tick;vector-borne pathogen

PROJECT_TITLE: Development of a novel multipurpose model to propagate and study the tick transmission cycle of relapsing fever spirochetes from Eurasia.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DCAI-J(03)]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

ORG_CITY: DAVIS

ORG_DEPT: PHYSICAL MEDICINE & REHAB

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

ORG_STATE: CA

PHR: This proposal contributes to the NINDS Network for Excellence in Neuroscience (NeuroNEXT) by renewing a clinical research site at the University of California Davis Health System located in Sacramento, CA, the capital of the most populous state in the country and one of the most diverse and integrated cities in the U.S. The UC Davis NeuroNEXT clinical research site will continue to contribute to public health by supporting the mission of NINDS and reducing the burden of neurologic diseases. It will add to infrastructure that expands the NINDS capability to test promising new therapies, increase the efficiency of clinical trials, and respond quickly as new opportunities arise to test promising treatments for people with neurological disorders.

PI_NAMEs: MCDONALD, CRAIG M. (contact)

PROGRAM_OFFICER_NAME: OHAYON, JOAN M

PROJECT_TERMS: Address;Adult;Affect;Biological Markers;biomarker validation;burden of illness;California;Capital;career;Cell Therapy;Characteristics;Childhood;Cities;Clinic;Clinical;Clinical Investigator;clinical outcome measures;Clinical Research;clinical research site;Clinical Trials;Clinical Trials Cooperative Group;Clinical Trials Network;Community Outreach;community partners;Country;Data;design;Development;digital health;Disease;Disease Management;drug development;drug discovery;Electronics;Environment;experience;Faculty;Foundations;Functional disorder;functional improvement;Funding;Future;gene therapy;gene therapy clinical trial;Gene therapy trial;Goals;Health system;improved;Industry;Infrastructure;innovation;Institution;Link;Medicine;Mission;National Institute of Neurological Disorders and Stroke;Natural History;Nervous System Disorder;Neurology;Neurosciences;Neurosciences Research;new therapeutic target;novel therapeutics;Outcome;outreach;Patient Recruitments;patient retention;Patients;Personal Satisfaction;Persons;Phase II Clinical Trials;Population;Population Scientist Supplement (R25);Positioning Attribute;Preparation;programs;Protocols documentation;Public Health;Public Health Informatics;Quality of life;recruit;Regenerative Medicine;Research;Research Infrastructure;Research Personnel;Research Training;Resource Informatics;Resources;response;Scientist;Site;skills;sound;Standardization;success;supportive environment;System;telehealth;Testing;Therapy Clinical Trials;Time;Training;Translational Research;translational research program;United States National Institutes of Health;Universities;Vision;Work

PROJECT_TITLE: NINDS Network for Excellence in Neuroscience: Clinical Research Site at UC Davis


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Biotechnology;Brain Disorders;Genetics;HIV/AIDS;Human Genome;Infectious Diseases;Mental Health;Neurodegenerative;Neurosciences

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

PHR: The research will utilize single cell RNA sequencing technology to examine brain autopsy specimens from individuals who were HIV-1-infected and treated with suppressive antiviral therapy prior to death. The research will focus on mechanisms that regulate HIV-1 replication, latency, and neuropathogenesis in the brain. The project will inform therapeutic strategies to tackle the HIV-1 infection of the brain.

PI_NAMEs: COARFA, CRISTIAN ;RICE, ANDREW P (contact);WALSS-BASS, CONSUELO

PROGRAM_OFFICER_NAME: RAO, VASUDEV RAMACHANDRA

PROJECT_TERMS: Anti-viral Therapy;antiretroviral therapy;Autopsy;Bioinformatics;Blood;Brain;CD4 Positive T Lymphocytes;Cell Line;Cell Nucleus;cell type;Cells;Cessation of life;Chromatin;Cognition;Cognitive;Cognitive deficits;Collection;Data;Dementia;Diagnosis;Effectiveness;Epigenetic Process;experimental study;Gene Expression;gene network;Genetic Transcription;Goals;High Prevalence;Hippocampus;HIV-1;HIV-associated neurocognitive disorder;Human;In Vitro;Individual;induced pluripotent stem cell;Infection;insight;Knock-out;latent virus activation;Lymphoid Tissue;Messenger RNA;Microglia;MicroRNAs;Minor;miRNA expression profiling;motor disorder;neuroAIDS;Neurocognitive Deficit;neurocognitive disorder;Neuropathogenesis;neurotropic;novel;novel therapeutic intervention;overexpression;Persons;Prefrontal Cortex;Prior Therapy;reactivation from latency;Research;Role;Sample Size;Sampling;single cell analysis;single nucleus RNA-sequencing;single-cell RNA sequencing;Site;Specimen;Technology;Therapeutic;Toxic effect;transcriptome sequencing;United States;Untranslated RNA;Validation;Viral;Viral reservoir;Virus;Virus Latency;Virus Replication;Work

PROJECT_TITLE: Single Cell Analysis of Epigenetic Mechanisms that Regulate HIV-1 CNS Latency and Neuropathogenesis


NIH_SPENDING_CATS: Autoimmune Disease;Fibromyalgia;Infectious Diseases;Lyme Disease;Pain Research;Precision Medicine;Tickborne Diseases;Vector-Borne Diseases

ORG_CITY: BOSTON

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: TUFTS UNIVERSITY BOSTON

ORG_STATE: MA

PHR: NARRATIVE Borrelia burgdorferi, the causative agent of Lyme disease, appears to steal elements of host cells which may shroud it from the host immune system. One consequence of this is the development of “auto” antibodies which recognize host components during the course of Lyme disease. We will study the role of the auto- antibodies in the development of disease, including in patients who have prolonged symptoms after treatment and determine whether they are involved as the cause of these symptoms and also if they can be used to develop better diagnostic tests for Lyme disease.

PI_NAMEs: HU, LINDEN T (contact)

PROJECT_TERMS: acute infection;Affinity;Aftercare;Animal Model;Animals;Antibiotic Therapy;Antibodies;Anticardiolipin Antibodies;Antigen-Antibody Complex;Antigens;Antiphospholipid Antibodies;Area;Arthralgia;Autoantibodies;Autoimmune;Autoimmune Diseases;Autoimmune Process;Autoimmunity;autoreactivity;Bacteria;Bacterial Proteins;behavioral study;Binding;biomarker identification;Borrelia burgdorferi;brain tissue;Cardiolipins;cell injury;Cells;Communicable Diseases;Complement Activation;cost;cross reactivity;Defect;Deposition;derepression;Development;Diagnostic tests;Disease;Elements;Environment;Fatigue;Fibromyalgia;fibromyalgia patients;Generations;Genome;histological studies;Human;Hypersensitivity;Immune response;Immune system;Immunoglobulin G;Immunologic Stimulation;Infection;Injections;Laboratories;Link;Lipids;Locomotion;Long COVID;Lyme Disease;lyme pathogenesis;Macrophage;Membrane;Memory B-Lymphocyte;Memory Loss;Metabolic;Modeling;Mus;Myalgia;Nerve Block;neural;Neurologic;Neurons;Nutrient;Organism;Pain;Pathogenesis;pathogenic autoantibodies;Pathogenicity;patient subsets;Patients;persistent symptom;Persons;Phospholipids;Plasmin;Post Treatment Lyme Disease Syndrome;predictive marker;Process;Production;Reagins;Receptor Activation;Residual state;Resolution;response;Role;Serum;Signal Transduction;Symptoms;Synaptic Transmission;Syphilis;Testing;Theft;Time;Tissues;treatment response

PROJECT_TITLE: Auto-antibodies as predictive markers for Post treatment Lyme Disease Syndrome


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Depression;Mental Health;Mental Illness;Patient Safety;Pediatric;Pediatric Cancer;Prevention;Rare Diseases;Urologic Diseases

ORG_CITY: IRVINE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: Project Narrative The majority of young adult cancer survivors experience impairing, distressing, and modifiable physical, behavioral, and psychosocial adverse outcomes that persist long after the completion of primary medical treatment including psychological distress and poor psychosocial adjustment, impairment in the navigation and pursuit of life goals, persistent treatment side effects, elevated risk of secondary malignancies and chronic illness, and biobehavioral burden (e.g., enhanced inflammation, dysregulated diurnal stress hormones). Yet, few targeted, effective interventions exist to assist young survivors in re-negotiating life goals and regulating cancer-related emotions and none focus on reducing the burden of morbidity via biobehavioral mechanisms. Responsive to the need for feasible, effective, and scalable interventions, this study will utilize a randomized, controlled, repeated measures design to investigate the efficacy of a novel intervention (Goal-Focused Emotion Regulation Therapy or “GET”) vs. Individual Supportive Listening (ISL) to improving depressive symptoms (primary outcomes) as well as emotion regulation, goal attainment skills, and career confusion (secondary outcomes) in young adult testicular cancer patients, whether GET is associated with reductions in biological markers of stress and inflammation, and evaluate whether gains in emotion regulation and goal attainment skills reflect mechanisms of underlying change at baseline, post-treatment, 3-month follow-up, and 6-months follow-up.

PI_NAMEs: HOYT, MICHAEL A (contact)

PROGRAM_OFFICER_NAME: MOLLICA, MICHELLE A

PROJECT_TERMS: Address;Adverse effects;adverse outcome;Aftercare;Age;anakinra;anxiety symptoms;Behavior Therapy;Behavioral;biobehavior;Biological Factors;Biological Markers;Biological Sciences;California;cancer diagnosis;Cancer Patient;Cancer Survivor;cancer therapy;career;Chronic Disease;Clinic;Cohort Studies;comparative;Comprehensive Cancer Center;Confusion;County;depressive symptoms;design;Disease;Distress;DNA Methylation;Economics;Education;effective intervention;efficacy evaluation;emerging adulthood;emotion regulation;Emotional;Emotions;Epigenetic Process;experience;Family;follow-up;General Population;Genes;Glucocorticoid Receptor;Goals;Hormones;Hydrocortisone;Impairment;improved;Individual;Inflammation;Informal Social Control;Interleukin-6;Interruption;Intervention;Late Effects;Life;life span;Malignant neoplasm of testis;Malignant Neoplasms;Measures;Mediation;Medical;Memorial Sloan-Kettering Cancer Center;Mental Depression;mood regulation;Morbidity - disease rate;neoplasm registry;novel;NR3C1 gene;Oncology;Oranges;Outcome;Participant;Pattern;Pediatric Hospitals;pilot test;Population;Positioning Attribute;post intervention;Prevalence;primary outcome;Production;psychologic;psychological distress;Psychological Factors;psychosocial;psychosocial adjustment;Race;Random Allocation;Randomized;Receptor Gene;recruit;Reproductive Health;Research;Resolution;response;Risk;Salivary;Second Primary Cancers;secondary outcome;serotonin transporter;Sexuality;side effect;skills;Stress;stress reactivity;success;Survivors;survivorship;systemic inflammatory response;Testing;therapy design;Time;Treatment Side Effects;Urologic Oncology;Value of Life;video chat;Videoconferencing;Work;young adult

PROJECT_TITLE: A Biobehavioral Intervention to Reduce Adverse Outcomes in Young Adult Testicular Cancer Survivors

STUDY_SECTION: BMHO

STUDY_SECTION_NAME: Biobehavioral Medicine and Health Outcomes Study Section[BMHO]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Infectious Diseases;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Prevention;Vaccine Related;Women's Health Research

ORG_CITY: LOS ANGELES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE There are limited data on SARS-CoV-2 hybrid immunity, defined as vaccine-induced immunity before or after natural infection, in pregnant women. As SARS-CoV-2 becomes endemic, this proposal will address a gap in the literature by examining the long-term clinical sequelae, systemic inflammatory changes, and immunologic responses to SARS-CoV-2 hybrid immunity in pregnancy, a state marked by tightly regulated T cell control and immune modulation. This study will inform knowledge on the immunopathogenesis of SARS-CoV-2 and other viral pathogens in pregnancy, which can be translated to improve maternal-fetal health through optimal vaccine strategies, the development of biomarkers for maternal risk stratification, and therapeutics in the future.

PI_NAMEs: CAMBOU, MARY CATHERINE (contact)

PROGRAM_OFFICER_NAME: BOZICK, BROOKE ALLISON

PROJECT_TERMS: 2019-nCoV;Adult;Age Months;Biological Assay;biomarker development;biomarker identification;Birth;career;CD8-Positive T-Lymphocytes;Childhood;Clinical;Communicable Diseases;COVID-19;COVID-19 complications;COVID-19 diagnosis;COVID-19 severity;COVID-19 treatment;COVID-19 vaccine;cytokine;Data;Diagnosis;Discipline of obstetrics;Disease;emerging pathogen;emerging virus;env Gene Products;Enzyme-Linked Immunosorbent Assay;Fetal health;Foundations;Funding;Future;Hybrids;Immune;Immune response;Immunity;Immunoglobulin G;Immunology;immunoregulation;improved;Infant;Infection;Inflammatory;Inflammatory Response;insight;Interdisciplinary Study;Interferon Type II;Knowledge;Life;Literature;Longitudinal cohort;Maternal Health;maternal morbidity;maternal outcome;maternal risk;Measures;Mentors;Mentorship;Messenger RNA;Mothers;Neonatal;neonatal health;neonate;Neutralization Tests;neutralizing antibody;Nucleocapsid;Only Child;Outcome;pandemic disease;Participant;Passive Immunity;pathogenic virus;Perinatal;Perinatal Infection;Peripheral Blood Mononuclear Cell;Phase;placental transfer;Population;post SARS-CoV-2 infection;postpartum complications;Postpartum Period;Pregnancy;Pregnant Women;Prevalence;prevent;Proteins;receptor binding;Recommendation;Records;Research Personnel;response;Risk;Risk Factors;risk stratification;RNA vaccination;Role;SARS-CoV-2 antibody;SARS-CoV-2 infection;SARS-CoV-2 spike protein;Scientist;Serology;Seroprevalences;Site;skills;Societies;sociodemographics;stem;systemic inflammatory response;T cell response;T-Lymphocyte;Testing;Therapeutic;therapeutic development;Time;Translating;translational physician;treatment guidelines;United States National Institutes of Health;Vaccination;vaccine development;vaccine strategy;vaccine-induced immunity;Vaccines;Viral;Virus Diseases

PROJECT_TITLE: SARS-CoV-2 in Pregnancy: Comparison of Natural Infection and Hybrid Immunity in Mother-Infant Pairs

STUDY_SECTION: AITC

STUDY_SECTION_NAME: Allergy, Immunology, and Transplantation Research Committee[AITC]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_DEPT: GENETICS

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

PHR: Project Narrative Mitochondria are responsible for generating the majority of the energy and building blocks in cells, and alterations in mitochondrial function are linked to many diseases, including cancer, diabetes, and neurodegenerative disorders. Little is known about how mitochondria take up nicotinamide adenine dinucleotide (NAD) – a cofactor in redox metabolism and metabolic signaling – and adjust this uptake in response to metabolic demands. Our studies will elucidate the mechanisms of cellular NAD compartmentalization, identify new modes of metabolic regulation, and unravel how modulation of NAD levels contributes to human physiology and disease.

PI_NAMEs: KORY, NORA  (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TERMS: Age related pathologies;Aging;Area;axonal degeneration;Biochemical;Biological Assay;Cells;cofactor;Consumption;Diabetes Mellitus;Disease;DNA Repair;driving force;Electrons;Genes;Goals;Health;healthspan;Homeostasis;Human;human disease;Inner mitochondrial membrane;insight;Laboratories;Link;Liver;loss of function;Malignant Neoplasms;Metabolic;Metabolic Control;Metabolism;Mitochondria;mitochondrial dysfunction;mouse model;Neurodegenerative Disorders;Nicotinamide adenine dinucleotide;Organelles;Oxidation-Reduction;Physiology;Process;programs;Proteins;proteoliposomes;Regulation;Research;Respiration;response;Role;Signal Pathway;Signal Transduction;Signaling Molecule;Signaling Protein;Sirtuins;Stress;transcription factor;uptake

PROJECT_TITLE: Dissecting metabolic control by cytosolic-mitochondrial NAD compartmentalization

STUDY_SECTION: MRAD

STUDY_SECTION_NAME: Maximizing Investigators' Research Award - D Study Section[MRAD]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Dementia;HIV/AIDS;Infectious Diseases;Neurodegenerative;Neurosciences;Stroke;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: CORAL GABLES

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: PROJECT NARRATIVE This application will evaluate the mechanistic events underlying the impact of HIV infection on cerebral small vessel disease (CSVD) in relationship to transient ischemic attack (TIA) outcome and recovery (Aim 1) and HIV reactivation in the CNS and its egress into the periphery (Aim 2). The central hypothesis of the proposal is that HIV-induced cerebral vascular pathology drives neuroimmune activation, predisposing HIV-infected brains to the development of CSVD and more severe TIA outcomes. The obtained results will have a potential to be a major breakthrough by its focus on novel mechanisms underlying vascular comorbidities in the HIV- infected brains.

PI_NAMEs: TOBOREK, MICHAL  (contact)

PROGRAM_OFFICER_NAME: WARREN, RONALD Q

PROJECT_TERMS: Anti-Retroviral Agents;antiretroviral therapy;Autopsy;Bioenergetics;Black Populations;Blood Vessels;blood-brain barrier disruption;Brain;Brain Ischemia;Brain Pathology;Cerebral small vessel disease;cerebrovascular;Cerebrovascular system;Cerebrum;comorbidity;comparison control;Data;Development;efavirenz;Event;Exposure to;Funding;Generations;Goals;HIV;HIV Infections;HIV Seropositivity;Impaired cognition;Incidence;Individual;Inflammatory Response;innovation;insight;Ischemia;ischemic injury;ischemic lesion;Ischemic Stroke;Lesion;Link;Mitochondria;mitochondrial dysfunction;National Heart, Lung, and Blood Institute;neuroAIDS;Neuroimmune;Not Hispanic or Latino;novel;occludin;Outcome;Pathology;Patients;Pharmaceutical Preparations;Phase;Population Control;Process;Proteins;Publishing;Recovery;Recurrence;Research;Risk;Role;Severities;statistics;Stroke;Therapeutic Intervention;Tight Junctions;Time;Transient Ischemic Attack;Vascular Diseases;vascular risk factor;Woman;Work

PROJECT_TITLE: Role of cerebral vasculature in brain ischemia in HIV infection

STUDY_SECTION: HVCD

STUDY_SECTION_NAME: HIV Molecular Virology, Cell Biology, and Drug Development Study Section[HVCD]


NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Lung Cancer;Prevention;Social Determinants of Health

ORG_CITY: GAINESVILLE

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: NARRATIVE Currently, it is unclear whether guideline-recommended CT imaging surveillance among patients with early-stage lung cancer improves survival. Our proposed study has direct value for advancing public health by examining real-world, timely data on the outcomes of lung cancer surveillance. The project will combine multimodal real- world data with simulation modeling to fill critical clinical and policy gaps regarding lung cancer surveillance.

PI_NAMEs: BRAITHWAITE, DEJANA K (contact);GOULD, MICHAEL K;GUO, YI ;JEON, JIHYOUN

PROGRAM_OFFICER_NAME: MARCUS, PAMELA M

PROJECT_TERMS: Adopted;Age;Alabama;American Society of Clinical Oncology;black patient;Body Weight decreased;Cancer Etiology;Cancer Intervention and Surveillance Modeling Network;Cancer Patient;Catalogs;Cessation of life;Characteristics;Chest Pain;Clinical;Clinical Research;clinical trial enrollment;Clinical Trials;Collaborations;Community Networks;Community of Practice;Community Practice;comorbidity;comparative effectiveness;compare effectiveness;Coughing;Data;data integration;Data Sources;Decision Analysis;Decision Making;Detection;Diagnostic Imaging;electronic health data;Electronic Health Record;electronic structure;Ethnic Origin;European;evidence based guidelines;Excision;Florida;Funding;Future;Geography;Goals;Guidelines;Image;improved;Infrastructure;innovation;Knowledge;Lead;lung cancer screening;Malignant neoplasm of lung;Malignant Neoplasms;Modeling;models and simulation;mortality;multimodality;Natural Language Processing;Non-Small-Cell Lung Carcinoma;Operative Surgical Procedures;Outcome;participant enrollment;patient oriented;patient population;Patients;Pattern;Policies;Population;Population Heterogeneity;Prognosis;Prospective cohort;Public Health;pulmonary function;Race;Radiology Specialty;randomized, clinical trials;Recommendation;Recurrence;Registries;Reporting;repository;Research;Retrospective cohort;rurality;Scanning;screening;Shortness of Breath;Smoking Status;social health determinants;sociodemographics;Socioeconomic Status;socioeconomics;study population;surveillance data;surveillance imaging;surveillance strategy;Survival Rate;Symptoms;System;Thoracic Radiography;unstructured data;uptake;X-Ray Computed Tomography

PROJECT_TITLE: Advancing Precision Lung Cancer Surveillance and Outcomes in Diverse Populations (PLuS2)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HSS-P(90)S]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Contraception/Reproduction;Genetics;Human Genome;Neurosciences;Women's Health Research

ORG_DEPT: PSYCHIATRY

PHR: PROJECT NARRATIVE Females of diverse species exhibit flexible changes in behavior in order to maximize their reproductive success and survival of their progeny. How particular neural circuits in the brain enable such flexible changes in behaviors is poorly understood but of vital importance to further well-being of mothers and their newborns. We have identified a group of neurons in the female mouse brain that may mediate flexible changes in behavior and have proposed a series of experiments to characterize their contribution to behavioral flexibility.

PI_NAMEs: SHAH, NIRAO MAHESH (contact)

PROGRAM_OFFICER_NAME: RAVINDRANATH, NEELAKANTA

PROJECT_TERMS: 4-Hydroxy-Tamoxifen;Aggressive behavior;Animals;Architecture;Behavior;Behavioral;Brain;Candidate Disease Gene;Caring;Cell Nucleus;Cells;Childbirth;Conceptions;cost;Cues;Data;Discipline of Nursing;Disease;Ejaculation;Embryo;Event;Exhibits;experience;experimental study;Female;Fiber;flexibility;Fluorescent in Situ Hybridization;genetic approach;Genomics;Goals;Halorhodopsins;Health;Heterogeneity;Human;Human Biology;Image;implantation;in vivo;insight;Kinetics;Label;Light;male;Mammals;Maps;Mediating;Molecular;Molecular Genetics;Mothers;Mus;Nervous System;neural circuit;Neural Pathways;Neurons;Neurosciences;Newborn Infant;optogenetics;Organism;Outcome;Partner in relationship;Peripheral;Personal Satisfaction;Photometry;Physiological;Physiology;Population;postsynaptic;Pregnancy;presynaptic;Process;Rabies;Reproduction;reproductive;Reproductive Behavior;reproductive organ;reproductive success;Resolution;response;sensor;Sensory;Series;Sexual Abstinence;Sexual Reproduction;single nucleus RNA-sequencing;Social Behavior;Social Interaction;Specificity;Structure of terminal stria nuclei of preoptic region;success;Territoriality;Testing;Transgenes;Uterus;Viral;Viscera;Visceral;Well in self;Woman;women's outcomes;Work

PROJECT_TITLE: Genomic and neural circuit characterization of interoceptive experience-modulated female behavior in mice

STUDY_SECTION: NIC

STUDY_SECTION_NAME: Neuroscience of Interoception and Chemosensation Study Section[NIC]


ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE Quantitative literacy incorporates mathematical knowledge, statistics, reasoning and attitudes to assign meaning to numerical data. Being proficient in quantitative literacy is a vital skill in scientific research, contributing to a thorough understanding of one’s field of study, appropriateness in one’s experimental design, and one’s ability to report data clearly. We propose an innovative and interactive training program that will provide users at multiple experience levels with a broader knowledge base of quantitative literacy skills in order to best promote scientific rigor in their work.

PI_NAMEs: GOMBASH LAMPE, SARA ELIZABETH (contact)

PROGRAM_OFFICER_NAME: CRAWFORD, DEVON CHRISTINE

PROJECT_TERMS: Active Learning;Address;Adult;Advisory Committees;Area;Attitude;Behavioral;Competence;complex data;Critiques;Data;Data Analyses;data literacy;Data Reporting;Data Set;Decision Making;design;Development;Discipline;Doctor of Philosophy;Education;education research;education resources;Educational Curriculum;Educational Materials;Educational process of instructing;Educational Status;Educational workshop;equity, diversity, and inclusion;Evaluation;experience;Experimental Designs;Failure;field study;Foundations;Funding;Generations;high school;higher education;improved;innovation;interest;Internships;Knowledge;Knowledge acquisition;knowledge base;Learning;Life;literacy;Literacy Programs;literate;Logic;mathematical ability;Mathematics;Mission;Molecular;National Institute of Neurological Disorders and Stroke;Nervous System Disorder;Neurosciences;novel;Ohio;pedagogical content;Performance;Postbaccalaureate;preservation;Process;Program Accessibility;programs;Publications;Reading;Reporting;Research;Resources;Role;Science;Scientific Advances and Accomplishments;scientific literacy;simulation;skills;Solid;Statistical Methods;statistics;student training;Students;Training;training opportunity;Training Programs;undergraduate student;United States National Institutes of Health;Universities;Visual Literacy;wasting;Work

PROJECT_TITLE: Understanding the Numbers: Quantitative Literacy for Experimental Rigor


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse;Women's Health Research

ORG_CITY: NEW ORLEANS

ORG_NAME: LSU HEALTH SCIENCES CENTER

ORG_STATE: LA

PHR: PROJECT NARRATIVE HIV infection among cisgender women who use drugs (WWUD) in the US South is a significant public health issue; WWUD with diverse marginalized identities (e.g., Black heterosexual, White sexual minority), have complex proximal (e.g., syringe sharing) and distal (e.g., intersectional stigma experiences in healthcare settings) HIV risk/resilience experiences that require further examination to develop effective interventions. Through the proposed mixed-method research we will 1) describe HIV risk and PrEP continuum disparities among WWUD in the US South by identifying subgroups of WWUD based on intersectional identity (e.g., Black heterosexual woman) and contextual factors (e.g., sex exchange); 2) explore multi-level barriers/facilitators (e.g., intersectional stigma, social support) in HIV prevention-related healthcare, HIV risk, and the PrEP continuum among WWUD sub-populations; and 3) explore institutional practices related to WWUD identified multi-level barriers/facilitators to HIV prevention-related healthcare seeking, HIV risk, and the PrEP continuum. Successful completion will yield empirical evidence regarding unique HIV risk/resilience experiences experienced by WWUD sub-groups critical insights to inform multi-level intersectional stigma-reduction, HIV prevention, and PrEP promotion initiatives.

PI_NAMEs: GLICK, JENNIFER L (contact)

PROGRAM_OFFICER_NAME: LEE-WINN, ANGELA EUNJI

PROJECT_TERMS: AIDS prevention;alcohol misuse;Attention;Awareness;barrier to care;Behavioral;Bioethics;Black Populations;Black race;care seeking;career;career development;cis-female;Cities;Clinic;cohort;Complement;Complex;contextual factors;coping;Data;Data Sources;design;Development Plans;Discrimination;disparities in women;Disparity;Distal;drug misuse;Drug usage;effective intervention;ethnographic method;Ethnography;experience;Fostering;Funding;German population;Goals;Grant;Health;health care settings;Health Disparities Research;health equity;Healthcare;Heterosexuals;HIV;HIV disparities;HIV Infections;HIV risk;housing instability;illicit drug use;Incidence;injection drug use;innovation;insight;Institution;Institutional Practice;intersectionality;Intervention Studies;Interview;lens;maladaptive behavior;marginalization;Mentors;Methodology;Methods;Needle Sharing;non-heterosexual;Outcome;Pattern;Personal Satisfaction;Play;Policies;Positioning Attribute;pre-exposure prophylaxis;Prevalence;Prevention Research;protective behavior;protective factors;Provider;Public Health;Qualitative Methods;Race;racial disparity;racism;Research;Research Activity;Research Design;Research Methodology;Research Personnel;Research Proposals;resilience;resilience factor;Resources;Risk;Risk Behaviors;Risk Reduction;Sampling;sex;Sex Behavior;Sex Orientation;sexual minority;sexual minority women;sexual risk behavior;skills;Social Processes;social stigma;Social support;Stress;structural determinants;Subgroup;substance use;surveillance data;Techniques;theories;therapy development;Time;Training;United States National Institutes of Health;Unsafe Sex;uptake;Violence;Vulnerable Populations;Woman;Writing

PROJECT_TITLE: HIV risk, PrEP disparities, and stigma among Women who use Drugs in the U.S. South, with attention to race and sexual orientation: A mixed-method intersectionality study


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics;Infertility;Pediatric;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

ORG_CITY: PASADENA

ORG_NAME: CALIFORNIA INSTITUTE OF TECHNOLOGY

PHR: Project Narrative How cells acquire their identities must be tightly coordinated with how tissues develop to their proper shapes in early mammalian embryos as they increase complexity from the implantation stages. Defects in this coordination often leads to embryonic lethality, which is one of the major causes of early pregnancy loss. My proposed work will reveal how the extracellular cues coordinate these processes required for early embryonic patterning and could inspire novel therapeutics to prevent early pregnancy loss.

PI_NAMEs: CHEN, DONG-YUAN  (contact)

PROGRAM_OFFICER_NAME: MUKHOPADHYAY, MAHUA

PROJECT_TERMS: 3-Dimensional;Anterior;Applied Skills;Architecture;Atlases;Award;Basement membrane;blastocyst;cell behavior;cell fate specification;Cell Lineage;cell motility;Cells;Chromosome Mapping;Cues;Death Rate;Defect;Development;Distal;early pregnancy;early pregnancy loss;Embryo;Embryonic Development;Endoderm;Epiblast;Epithelium;Event;extracellular;Extracellular Matrix;Failure;Fertilization;Fluorescent in Situ Hybridization;Foundations;gastrulation;Gene Expression Profile;gene function;Genes;genetic manipulation;Genetic Markers;genome-wide;Genomic approach;Genomics;Germ Layers;Heterogeneity;Human;Image;image processing;imaging approach;implantation;in silico;In Situ;In Situ Hybridization;In Vitro;in vivo;Individual;Learning;loss of function;mammalian embryology;Maps;mathematical model;Mechanics;Mentors;Mesenchymal;migration;Modeling;Molecular;molecular asymmetry;Morphogenesis;Mus;natural Blastocyst Implantation;new technology;New Territories;novel therapeutic intervention;novel therapeutics;Pattern;Pattern Formation;Phase;Play;Pregnancy;preimplantation;prevent;Primitive Streaks;Process;programs;quantitative imaging;Reaction;Regulation;Research;Resolution;Role;Shapes;skills;Specific qualifier value;stem cell model;stem cells;System;Techniques;Technology;Testing;Time;Tissues;tool;Training;transcriptomics;Visceral;Work

PROJECT_TITLE: Integrating cell identities and morphodynamics through extracellular cues


NIH_SPENDING_CATS: Bioengineering;Cancer;Genetics;Immunotherapy;Machine Learning and Artificial Intelligence

ORG_CITY: CAMBRIDGE

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: HARVARD UNIVERSITY

PHR: Project Narrative. T-cells and macrophage immune cells can promote or restrain tumor progression. Mounting evidence suggests that their spatiotemporal co-dependency and physical properties of the environment dictate their pro- or anti- tumor characteristic. I propose a multipronged approach to elucidate the mechanisms by which these variables shape their behavior.

PI_NAMEs: ADEBOWALE, KOLADE  (contact)

PROGRAM_OFFICER_NAME: GIBBS, KENNETH D

PROJECT_TERMS: 3-Dimensional;Adopted;Adoptive Cell Transfers;advanced disease;Alginates;Alzheimer's Disease;Arthritis;Atherosclerosis;Basement membrane;Behavior;Biochemical;Biological Assay;biophysical properties;Biophysics;cancer cell;cancer immunotherapy;cancer infiltrating T cells;CD8-Positive T-Lymphocytes;cell behavior;Cell Communication;cell killing;Cell Physiology;Cell Shape;Cells;Cessation of life;Characteristics;Cholesterol;Clinical;Computer Analysis;computerized tools;confocal imaging;Cues;cytokine;Data;Dependence;Diabetes Mellitus;Disease;Disease Progression;Elasticity;Encapsulated;Environment;Epigenetic Process;Evolution;exhaustion;Exhibits;Extracellular Matrix;fighting;Flow Cytometry;Genetic;Genetic Transcription;global health;Harvest;Heterogeneity;Homing;human disease;Hydrogels;Image;Immune;Immune response;Immune signaling;Immunofluorescence Immunologic;Immunology;Immunophenotyping;Immunotherapy;in vivo;Inflammation;Inflammation Mediators;Inflammatory;inflammatory modulation;insight;Liquid substance;machine learning algorithm;Macrophage;Malignant Neoplasms;Mammary Neoplasms;Measurement;Mechanics;Membrane Lipids;Modification;Monitor;Morphology;Mus;Myeloid Cells;nanobodies;novel;novel therapeutics;Nuclear Translocation;Pathology;Pharmaceutical Preparations;Phenotype;physical property;programmed cell death protein 1;programs;Property;receptor;reconstitution;Research;Resolution;response;restraint;Role;Series;Shapes;Signaling Molecule;single cell analysis;single-cell RNA sequencing;small molecule inhibitor;Solid;spatiotemporal;spheroids;Surface;System;T-Lymphocyte;Time;Tissues;tool;trafficking;transcription factor;transcriptome sequencing;translational impact;tumor;tumor microenvironment;tumor progression;Tumor-associated macrophages;two-dimensional;unsupervised learning;viscoelasticity;Viscosity

PROJECT_TITLE: BIOPHYSICAL CUES SHAPING MACROPHAGE AND T-CELL FUNCTIONS


NIH_SPENDING_CATS: Autoimmune Disease;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Disability Research;Multiple Sclerosis;Neurodegenerative;Neurosciences

ORG_CITY: SAINT LOUIS

ORG_DEPT: NEUROLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Narrative Despite highly effective medications for the initial treatment of relapsing remitting multiple sclerosis (MS), many patients develop progressive MS wherein neurological disability accumulates despite medical treatment. We plan to investigate how brain inflammation and metabolic stress combine to contributes to MS pathophysiology using a combination of positron emission tomography (PET) and magnetic resonance imaging (MRI). Further understanding of the contributors to MS may uncover new treatment targets or allow for more precise monitoring of disease activity.

PI_NAMEs: BRIER, MATTHEW RYAN (contact)

PROGRAM_OFFICER_NAME: REZAIZADEH, KAVON PAUL

PROJECT_TERMS: Affect;Age;anti-CD20;Atrophic;Axon;B cell therapy;B-Lymphocytes;Binding;Biological Markers;blood-brain barrier crossing;brain tissue;Cell Death;Cells;Central Nervous System Degenerative Diseases;Cerebrum;chronic demyelination;Clinical;Clinical assessments;cohort;comparison control;Data;Demyelinating Diseases;Demyelinations;disability;Disability status;Disease;Disease remission;Drug Modulation;effective therapy;efficacious treatment;Encephalitis;Equilibrium;Evaluation;Failure;FDA approved;fluorodeoxyglucose;Functional disorder;Glucose;glucose uptake;Glycolysis;gray matter;Homeostasis;Image;imaging agent;Immune;Immunologics;Inflammation;Inflammatory;inflammatory marker;Inflammatory Response;Injury;interest;K-Series Research Career Programs;kinetic model;Knowledge;Lesion;lymphocyte trafficking;Magnetic Resonance Imaging;Measurement;Measures;Mediating;Medical;Mentors;Metabolic;metabolic imaging;metabolic rate;Metabolic stress;Metabolism;Modeling;Monitor;Morbidity - disease rate;Multiple Sclerosis;Multiple Sclerosis Lesions;multiple sclerosis patient;multiple sclerosis treatment;Mus;Myelin;Nature;Nerve Degeneration;nerve injury;neuroimaging;Neurological disability;novel;Outcome;overexpression;Oxygen;Participant;Pathology;Patients;Persons;Pharmaceutical Preparations;Positioning Attribute;Positron-Emission Tomography;Process;radiotracer;recruit;Refractory;Relapse;Relapsing-Remitting Multiple Sclerosis;repaired;response;Scanning;Signal Transduction;Sphingosine-1-Phosphate Receptor;Stress;Testing;Therapeutic;Tissues;treatment effect;treatment strategy;uptake;white matter

PROJECT_TITLE: PET and MRI Evaluation of Cerebral Inflammation and Metabolic Stress in Relapsing Multiple Sclerosis

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-1 Study Section[NST-1]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Depression;Mental Health;Mental Illness;Neurosciences;Serious Mental Illness

ORG_CITY: BLACKSBURG

ORG_DEPT: MISCELLANEOUS

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

ORG_STATE: VA

PHR: PROJECT NARRATIVE (RELEVANCE) Dopamine and serotonin jointly influence a broad range of healthy cognition and changes in their delivery or action are thought to underpin a variety of pathological conditions including major depressive disorder, drug addiction, attention-deficit-hyperactivity disorder, and Parkinson's Disease. During the window-of-opportunity afforded by deep brain stimulating (DBS) electrode implantation, we will make the first recordings of joint dopamine and serotonin dynamics in the striatum of conscious humans during the execution of inter-personal social exchange games. This work will address for the first time how these important neuromodulators encode social processes important for healthy cognition and affected by disease and injury.

PI_NAMEs: GU, XIAOSI ;KISHIDA, KENNETH TUCKER;MONTAGUE, P READ (contact)

PROGRAM_OFFICER_NAME: VAZIRI, SIAVASH

PROJECT_TERMS: Action Potentials;Affect;American Psychiatric Association;Antisocial Personality Disorder;arm;Attention deficit hyperactivity disorder;autism spectrum disorder;Behavior;Behavioral;Brain;Catecholamines;Cognition;cognitive function;Collaborations;Computer Models;Conscious;Consensus;Corpus striatum structure;Decision Making;Deep Brain Stimulation;Detection;Diagnostic;diagnostic criteria;Disease;Dopamine;dopamine system;Drug Addiction;Electrodes;Emotional;Emotions;Essential Tremor;Failure;Functional disorder;Goals;Health;Human;human model;implantation;information processing;Injury;Interpersonal Relations;Investments;Joints;Learning;Machine Learning;Major Depressive Disorder;Measurement;Measures;Mental Depression;Mental disorders;mental state;Methodology;Methods;Modeling;Moods;neural;neurochemistry;Neuromodulator;neuroregulation;Neurotransmitters;Norepinephrine;novel;Obsessive-Compulsive Disorder;Operative Surgical Procedures;Parkinson Disease;Pathologic;Patients;Perception;Persons;Play;Positive Valence;psychologic;putamen;Research Domain Criteria;Rewards;Risk;Role;Safety;Serotonergic System;Serotonin;Signal Transduction;Site;social;social communication;social deficits;Social Interaction;social norm;Social Perception;Social Processes;social relationships;System;Time;Ventral Striatum;Withdrawal;Work

PROJECT_TITLE: Computational and electrochemical substrates of social decision-making in humans


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Bioengineering;Neurosciences

ORG_NAME: MASSACHUSETTS EYE AND EAR INFIRMARY

PHR: Project Narrative The proposed research will help to address the needs of the millions of people with sensorineural hearing loss, by providing a better understanding of how the microscopic cellular and acellular structures of the cochlea work together to produce both the sensation of hearing and clinically useful otoacoustic emissions (OAEs) that can be measured non-invasively in the ear canal. By measuring the motions of cochlear structures in animals using state-of-the-art high-resolution optical coherence tomography (OCT), we will be able to create anatomically realistic 3D finite-element computational models of the inner ear and these models will, in turn, allow us to predict how a patient’s hearing and OAEs would be affected by specific types of structural damage or genetic mutations, thus providing a powerful way of diagnosing hearing problems in terms of their structural basis. These models may also accelerate the development of biological interventions centered around the regeneration of cochlear structures, by providing ways of predicting and comparing the hearing outcomes of various therapeutic strategies, or by providing understanding of the structural changes in the cochlea arising from noise damage; and such computer models may reduce the need for animal experimentation in the future.

PI_NAMEs: PURIA, SUNIL  (contact)

PROGRAM_OFFICER_NAME: CYR, JANET

PROJECT_TERMS: 3-Dimensional;Acceleration;Acoustic Stimulation;Address;Affect;Anatomic Models;Anatomy;Animal Experimentation;Animals;Apical;Area;Basal Plate;base;Basilar Membrane;biological development;Bulla;Cell Adhesion Molecules;Cell membrane;Cell Physiology;Cells;Clinical;Cochlea;Cochlear duct;Complex;Computer Models;Data;Diagnosis;DNA Sequence Alteration;Elements;Environment;Esthesia;experimental study;External auditory canal;flexibility;Frequencies;Funding;Future;Gerbils;Goals;hair cell regeneration;Hair Cells;Hearing;Hearing problem;hearing range;histological slides;Human;Image;In Situ;in vivo;Individual;Inner Hair Cells;Intercellular Junctions;Intervention;Knowledge;Labyrinth;Lead;Liquid substance;Location;machine learning algorithm;Measurement;Measures;Mechanics;meter;Microanatomy;Microscopic;Modeling;mosaic;Motion;Mus;Mutation;Natural regeneration;Noise;Optical Coherence Tomography;Organ of Corti;otoacoustic emission;Outcome;Outer Hair Cells;Pathology;Patients;Persons;Phalanx;Phase;Pillar Cell;pressure;Process;Property;Publishing;Radial;Research;Resolution;response;Role;Sensorineural Hearing Loss;sound;Specific qualifier value;Stereocilium;Stretching;Structure;System;Techniques;tectorial membrane;Tectum Mesencephali;Testing;Therapeutic;Thinking;Translating;Travel;two-photon;Viscosity;Wild Type Mouse;Work

PROJECT_TITLE: Measuring and Modeling the Cochlear Organ-of-Corti Motions Responsible for Inner-and Outer-Hair-Cell Drives and Amplification

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Cancer;Brain Disorders;Cancer;Gene Therapy;Genetics;Immunotherapy;Neurosciences;Nutrition;Orphan Drug;Rare Diseases

ORG_DEPT: NEUROSURGERY

PHR: NARRATIVE The metabolic switch observed in GBM leads to increased glycolysis in tumor cells and impacts the tumor microenvironment, which in turn acts as a major barrier for successful targeting of cancer by anti-tumor immune cells like T cells. The tremendous increase in tumor glucose consumption imposes a great metabolic pressure on T cells, which experience glucose restriction. The overarching goal of this project is to manipulate the metabolic fitness of chimeric antigen receptor (CAR) modified T cells to ameliorate their tumoricidal activity in the context of immunotherapy to treat GBM

PI_NAMEs: DELEYROLLE, LOIC PIERRE (contact)

PROGRAM_OFFICER_NAME: SINGH, ANJU

PROJECT_TERMS: Adoptive Transfer;Adult;aerobic glycolysis;Animals;Bioenergetics;Brain Neoplasms;cancer cell;cancer immunotherapy;cancer therapy;cancer type;CAR T cell therapy;Cell Line;Cells;Cellular Metabolic Process;Central Nervous System;Characteristics;Child;chimeric antigen receptor T cells;Clinical;clinical application;Clinical Trials;Consumption;design;Disease;effector T cell;engineered T cells;Engineering;Environment;Evaluation;experience;flexibility;Glioblastoma;Glioma;Glucose;glucose metabolism;Glucose Transporter;GLUT-3 protein;Glycolysis;Goals;Human;Immune;Immune Evasion;Immune response;Immune system;Immune System Diseases;Immunotherapeutic agent;Immunotherapy;improved;in vivo;Infiltration;innovation;interest;Laboratories;Link;Malignant neoplasm of brain;Malignant Neoplasms;Metabolic;metabolic engineering;metabolic fitness;Metabolic Pathway;Metabolism;Methods;Modeling;mouse model;Mutant Strains Mice;Nature;neoplastic cell;NF1 gene;Nutrient;Nutrient availability;overexpression;Pathway interactions;Patients;Phenotype;pressure;prognostic;programs;Proliferating;Protein Isoforms;Regulation;Reporting;Resistance;restraint;Role;Safety;SLC2A1 gene;Solid Neoplasm;success;Surveys;Survival Rate;T cell therapy;T-Cell Activation;T-Cell Receptor Therapy;T-Lymphocyte;Testing;Therapeutic;therapy resistant;thymocyte;tumor;Tumor Immunity;tumor microenvironment;Tumor-infiltrating immune cells;uptake

PROJECT_TITLE: Optimizing CAR T therapy via metabolic engineering for thetreatment of GBM


PHR: PROJECT NARRATIVE The proposed research is relevant to public health because Sonogenetics 2.0 provides the neuroscience community with a long-awaited tool for noninvasive and spatially precise manipulation of selected populations of neurons on a brain-wide scale. The noninvasiveness of this technique offers the potential to translate Sonogenetics 2.0 from rodent studies to large animal and human applications.

PI_NAMEs: CHEN, HONG  (contact)

PROGRAM_OFFICER_NAME: KUMSA, DOE WONDWOSSEN

PROJECT_TERMS: 3D Print;Acoustics;Address;adeno-associated viral vector;Animals;Area;Benchmarking;Biological;Biomedical Engineering;Brain;brain control;Brain Diseases;Brain region;Cell membrane;Cell Physiology;cell type;Collaborations;Communities;Corpus striatum structure;Data;Dependovirus;Development;Device Designs;Devices;Dopamine D1 Receptor;Drug Delivery Systems;efficacy evaluation;Engineering;Exhibits;Focused Ultrasound;free behavior;Gene Delivery;Genetic;Genetic Engineering;genetic manipulation;Goals;Human;improved;infancy;Injections;innovation;Intranasal Administration;Investigation;Ion Channel;Ions;Laboratories;lens;Light;Location;Mediating;Microbubbles;millisecond;Modality;Molecular Probes;Motor;motor control;multidisciplinary;Mus;Mutagenesis;mutant;neural;neural circuit;Neurons;neuroregulation;Neurosciences;Neurosciences Research;next generation;Operative Surgical Procedures;optogenetics;Penetration;Performance;Population;Process;Property;Public Health;Publishing;Research;Research Personnel;Research Project Grants;Resolution;response;Rodent;Safety;Serotyping;Sonication;Structure;Techniques;Technology;technology development;Tissues;tool;Transducers;Translating;translational potential;TRPV1 gene;Ultrasonic Therapy;Ultrasonic Transducer;Ultrasonics;ultrasound;Validation;Variant;Viral Vector;wearable device

PROJECT_TITLE: Sonogenetics 2.0

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-NV-Q(91)S]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Bioengineering;Building Research Capacity at Institutions with Limited NIH Funding;Emerging Infectious Diseases;Infectious Diseases;Nanotechnology

ORG_CITY: CHARLOTTE

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF NORTH CAROLINA CHARLOTTE

ORG_STATE: NC

PHR: Narrative Antimicrobial resistant bacteria (ARB) and genes (ARGs) are one of the biggest public health issues of the 21st century. In this project; we propose to develop a light-activated silver nanoparticulate system for the effective treatment of ARB and ARGs. The proposed research is relevant to public health because it will develop reliable technologies for the effective elimination of ARB and ARGs.

PI_NAMEs: VIVERO-ESCOTO, JUAN LUIS (contact)

PROGRAM_OFFICER_NAME: CUPIT, PAULINE

PROJECT_TERMS: Aerobic;Anti-Bacterial Agents;anti-microbial drug;Antibiotic Resistance;antibiotic resistant infections;Antibiotics;antimicrobial;Antimicrobial Resistance;Area;Award;Bacteria;Bacterial Antibiotic Resistance;bacterial resistance;Biological;career;Cell Death;Cells;Chemicals;Chemistry;cytotoxic;cytotoxicity;Data;daughter cell;design;Development;DNA;Dyes;effective therapy;efflux pump;Environment;Environmental Engineering technology;Evaluation;extracellular;Formulation;Friends;Generations;Genes;Goals;graduate student;Grant;Horizontal Gene Transfer;innovation;Ions;irradiation;Kinetics;Light;Mammalian Cell;Membrane;Metabolic Pathway;microbial;Minimum Inhibitory Concentration measurement;Modality;Mutation;nanomaterials;nanoparticle;nanoparticulate;nanotechnology platform;novel;Outcomes Research;oxidation;pathogen;Pathway interactions;Persons;Photosensitizing Agents;Production;Property;protoporphyrin IX;Public Health;Pump;rational design;Reactive Oxygen Species;Reporting;Research;Resistance;Resistance development;resistance gene;resistance mechanism;Silver;Students;success;Surface;Surface Properties;System;Technology;Testing;Therapeutic;Therapeutic Effect;Training;Translating;Translations;undergraduate student;Visible Radiation

PROJECT_TITLE: Light-Activated Silver Nanoparticles to Eliminate Antibiotic Resistant Bacteria and Genes


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Emerging Infectious Diseases;Genetics;Infectious Diseases;Influenza;Pneumonia and Influenza

ORG_CITY: BOZEMAN

ORG_NAME: MONTANA STATE UNIVERSITY - BOZEMAN

ORG_STATE: MT

PHR: NARRATIVE Avian influenza A virus (IAV) infections in humans have high rates of morbidity and mortality rates but remain infrequent because host restrictions limit efficient viral replication and human to human transmission. However, rapid accumulation of mutations within the IAV genome can lead to extensive viral genetic diversity, thus increasing host adaptation, fitness, and transmissibility. We will quantify the extent and development of the adaptive mutations that can lead to enhanced IAV infections and explore how these mutations contribute to viral genetic diversity produced from different primary cell types.

PI_NAMEs: LOVEDAY, EMMA KATE (contact)

PROJECT_TERMS: A549;Address;airway epithelium;Avian Influenza A Virus;Bar Codes;biosafety level 3 facility;Birds;bronchial epithelium;Cell Differentiation process;cell immortalization;cell type;Cells;Death Rate;Development;digital;Drops;Emerging infection;emerging virus;Epithelial Cells;Evolution;experimental study;extracellular;fitness;gain of function;Gene Expression;Genetic Drift;Genetic Heterogeneity;Genetic Variation;Genomics;Heterogeneity;high throughput analysis;Human;Immune response;Individual;Infection;Influenza A virus;Influenza A Virus, H1N1 Subtype;Influenza A Virus, H3N2 Subtype;Influenza A Virus, H5N1 Subtype;Influenza A Virus, H5N2 Subtype;Influenza A Virus, H7N9 Subtype;Influenza A Virus, H9N2 Subtype;influenzavirus;insight;Laboratories;Messenger RNA;Methods;Microfluidics;Modeling;Morbidity - disease rate;mortality;Mutate;Mutation;Nasal Epithelium;Natural Selections;new pandemic;Nose;novel;Pathogenicity;pathogens of pandemic potential;Play;Population;Population Sizes;pressure;Process;Production;receptor binding;recombinant virus;Research;Resolution;Respiratory System;Risk;RNA Viruses;Role;Seasons;Serial Passage;single cell analysis;single-cell RNA sequencing;System;Testing;Therapeutic;transmission process;Vaccines;Variant;Viral;Viral Genome;viral genomics;viral RNA;viral transmission;virology;Virulence;Virulent;Virus;Virus Diseases;virus genetics;Virus Replication;Zoonoses;zoonotic spillover

PROJECT_TITLE: Single cell heterogeneity of influenza A virus genetic diversity and host adaptation using drop-based microfluidics

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-VDT-Q(01)]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Clinical Research;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Immunization;Infectious Diseases;Lymphatic Research;Prevention;Vaccine Related

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE Parasites infect millions of people every year, but there are no effective vaccines against food or waterborne parasite. We will generate 3D gut-vasculature lumen models, where parasites are introduced into the intestinal epithelium and human immune cells into the vasculature to monitor immune response and parasitic disease. For this proposal, we will use the orally infectious stages of the protozoan parasites Toxoplasma gondii and Entamoeba histolytica, and determine that human immune response that controls these infections.

PI_NAMEs: BEEBE, DAVID J;KERR, SHEENA CATHERINE;KNOLL, LAURA J (contact)

PROGRAM_OFFICER_NAME: PESCE, JOHN T

PROJECT_TERMS: 3-Dimensional;Address;Apical;Architecture;Binding;Biological Models;Biomimetics;Blood;Blood Vessels;Cell Communication;Cell Culture Techniques;Cells;Cessation of life;Clostridium difficile;Coculture Techniques;Congenital Abnormality;Cyst;cytokine;Data;Development;Devices;Disease;Disease Progression;Endothelium;Entamoeba histolytica;Enteral;enteric infection;Environment;Epithelial Cells;Epithelium;experimental study;Food;Food Contamination;Gene Expression;Goals;Growth;Helper-Inducer T-Lymphocyte;Human;human disease;human migration;human model;human pathogen;Hypoxia;Immune;Immune response;Immunity;Immunocompromised Host;Immunologic Monitoring;Immunology;improved;in vitro Model;Individual;Infant;Infection;Infection Control;Inflammation;Innate Immune Response;intestinal epithelium;Intestinal parasite;Intestines;Investigation;Knowledge;Lymphatic;Lymphatic Endothelial Cells;lymphatic vasculature;Malignant Neoplasms;Measures;Mediating;member;Microbiology;Microfluidic Microchips;Microfluidics;microphysiology system;migration;model development;Modeling;Monitor;monocyte;Morbidity - disease rate;mortality;mouse model;Mucous body substance;Mus;neutrophil;Nutrient;Oocysts;Oral;oral infection;Organoids;Parasite Control;Parasites;Parasitic Diseases;Parasitic infection;pathogen;pathogenic bacteria;Pathway interactions;Persons;Phagocytosis;Physiological;Population;Pregnant Women;Production;recruit;Research;response;Role;Route;S100 Proteins;S100A11 gene;Side;Small Intestines;System;Tissues;Toll-like receptor 11;Toxoplasma gondii;Toxoplasmosis;transmission process;Trees;vaccine access;vaccine development;Vaccines;Vascular Endothelial Cell;Water;waterborne;Work

PROJECT_TITLE: Development of a human intestinal microphysiological system for the study of immune responses to protozoan parasites

STUDY_SECTION: CMT

STUDY_SECTION_NAME: Cellular and Molecular Technologies Study Section[CMT]


NIH_SPENDING_CATS: Cancer;Clinical Research;Digestive Diseases;Genetics;Immunotherapy;Orphan Drug;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: NARRATIVE We propose to investigate the role of a particular type of immune cell that infiltrates a gastrointestinal cancer. We will define its biology, understand how it is altered by tumor therapy, and activate it for anti- tumor efficacy. The findings may lead to novel approaches to treat patients with cancer.

PI_NAMEs: DEMATTEO, RONALD P. (contact)

PROGRAM_OFFICER_NAME: HOWCROFT, THOMAS K

PROJECT_TERMS: Affect;anti-tumor immune response;Antibodies;Biology;Blood;CD8-Positive T-Lymphocytes;Cell Separation;Cells;cytokine;Cytotoxic Chemotherapy;Data;effective therapy;Exons;experimental study;Gastrointestinal Stromal Tumors;Genes;Genetic Engineering;Genetic Transcription;Germ Lines;Human;IL17 gene;Imatinib;Imatinib mesylate;immune cell infiltrate;Immune response;Immunocompetent;Immunotherapeutic agent;In Vitro;in vivo;Infiltration;Insulin-Like Growth Factor I;interleukin-18 receptor;Intestines;Knock-in Mouse;Macrophage;Malignant neoplasm of gastrointestinal tract;Malignant Neoplasms;Molecular;molecular targeted therapies;monocyte;mouse model;Mus;Mutate;Mutation;neoplastic cell;novel;novel strategies;novel therapeutic intervention;novel therapeutics;Oncoproteins;Operative Surgical Procedures;Patients;PDGFRA gene;Platelet-Derived Growth Factor alpha Receptor;Play;Production;Protein Tyrosine Kinase;Proto-Oncogenes;receptor;Resistance;Resistance development;RNA;Role;Sarcoma;single-cell RNA sequencing;Small Intestines;small molecule;Sorting;Specimen;Spleen;Stomach;T cell receptor repertoire sequencing;Testing;Time;Translating;Treatment Efficacy;tumor;tumor growth;Tumor-infiltrating immune cells;Tyrosine Kinase Inhibitor;unsupervised clustering;Work

PROJECT_TITLE: Molecular Mechanisms in Gastrointestinal Stromal Tumor

STUDY_SECTION: CII

STUDY_SECTION_NAME: Cancer Immunopathology and Immunotherapy Study Section[CII]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative A novel platform for genetically targeting specific types of glial cells in vivo, as proposed here, will enable the first time to study and treat pathologies shown to be driven by glia, which were thus far inaccessible to gene therapy and targeted manipulation. This novel gene therapy platform will enable to upregulate, downregulate, knock-out or replace faulty glia genes that play roles in diseases of the nervous system, among them neurodegeneration, pain disorders, affective disorders, autism, and brain cancers.

PI_NAMEs: SHEMESH, OR  (contact)

PROGRAM_OFFICER_NAME: DARINGER, NICHOLE MARIE

PROJECT_TERMS: 3' Untranslated Regions;5' Untranslated Regions;Acute;Address;Affect;Alzheimer's Disease;analog;Antibodies;aptamer;Astrocytes;autism spectrum disorder;Binding;Biomedical Engineering;Brain;Brain Diseases;cancer therapy;cell type;Cells;Cholesterol;Clinical;clinical application;Code;delivery vehicle;Dependovirus;design;Development;Disease;Engineering;Ependymal Cell;Exhibits;Gene Delivery;Gene Expression;Gene Targeting;gene therapy;Gene Transduction Agent;Genes;Green Fluorescent Proteins;healing;Hela Cells;Human;Image;Immune response;immunogenicity;in vivo;interest;Intervention;Knock-out;Lentivirus;lipid nanoparticle;Lipids;Luciferases;Luminescent Proteins;Malignant neoplasm of brain;Malignant Neoplasms;Medical;Methods;Microglia;Modeling;Modification;Molecular;Mood Disorders;Mus;Mutagenesis;Mutation;Nerve Degeneration;Nervous System Disorder;Neurodegenerative Disorders;Neuroglia;Neurons;non-viral gene delivery;novel;Oligodendroglia;Optics;Pain;Pain Disorder;Pathology;Play;Poly(A) Tail;prevent;Process;Proteins;Rapid screening;Reporter Genes;Research;RNA;RNA Stability;Role;screening;Specificity;Surface Antigens;Tail;targeted delivery;Technology;Testing;Therapeutic;Time;transmission process;Vaccination;Vascular Diseases;vector;Viral Vector;Virus

PROJECT_TITLE: Glia Exclusive Gene Therapy

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Opioid Misuse and Addiction;Opioids;Pediatric;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: UNIVERSITY PARK

ORG_DEPT: PSYCHOLOGY

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

PHR: Project Narrative  Various adverse and protective environments may affect child development. The Healthy Brain and Child Development National Consortium (HBCD-NC) will follow 7,500 mothers and their children from 24 locations across the U.S. from before birth to 10 years of age to better understand which harmful and protective environments exert the greatest impact on child development. This study will help to improve the health and development of children across the nation.

PI_NAMEs: PEREZ-EDGAR, KORALY E (contact);ZGIERSKA, ALEKSANDRA EWA

PROGRAM_OFFICER_NAME: PRABHAKAR, JANANI

PROJECT_TERMS: 10 year old;Address;Adverse event;Affect;Alcohols;Behavioral;Biological;Birth;Brain;Caregivers;caregiving;Child;child bearing;Child Development;cohort;Communities;Conceptions;COVID-19;critical period;Data;Data Collection;Data Coordinating Center;data integrity;Data Set;data standards;design;Development;DNA;early experience;early life exposure;Electroencephalography;Enrollment;Environment;Environmental Exposure;Environmental Hazards;Epigenetic Process;Ethics;Ethnic Origin;Event;experience;Exposure to;Feedback;General Population;Genes;Goals;hazard;Health;Helping to End Addiction Long-term;Human;improved;Infant;Infection;innovation;insight;Life;Link;Location;Magnetic Resonance Imaging;Malnutrition;maltreatment;Marijuana;Maternal Health;maternal stress;Measures;Methods;Modality;Monitor;Mothers;multidimensional data;multimodality;neurodevelopment;neuroimaging;Newborn Infant;novel;Opiate Addiction;Opioid;opioid misuse;Outcome;Participant;Persons;Physiological;Population;postnatal;Pregnancy;pregnant;Pregnant Women;prenatal;prenatal exposure;Process;protective factors;Protocols documentation;psychologic;Psychopathology;Public Health;Public Policy;Race;recruit;remote assessment;Research;Research Design;Research Personnel;Sampling;Second Pregnancy Trimester;Severities;Shapes;Site;socioeconomics;sound;Speed;stem;Stress;Structural Racism;substance use;Time;Time Study;Tobacco;tool;Toxicant exposure;Training;United States;United States National Institutes of Health;Woman;Work

PROJECT_TITLE: 13/24 The Healthy Brain and Child Development National Consortium

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-D(51)R]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Congenital Structural Anomalies;Hematology;Neurosciences;Pediatric

ORG_CITY: SCOTTSDALE

ORG_NAME: MAYO CLINIC ARIZONA

ORG_STATE: AZ

PHR: Narrative Arteriovenous malformation (AVM) is an abnormal connection between an artery and a vein that bypasses the normal capillary circulation, often resulting in a tangle of vessels called a nidus. Overstressed veins may enlarge, stretch, and eventually rupture leading to catastrophic bleeding. We propose a bioengineered gel embolic material (GEM) as a minimally invasive biomaterial-based platform to fill AVM vasculature using microcatheters with groundbreaking shear-thinning biomaterials.

PI_NAMEs: OKLU, RAHMI  (contact);ZHANG, Y. SHRIKE

PROGRAM_OFFICER_NAME: LIU, SONGTAO

PROJECT_TERMS: Ablation;Acute;age group;Age Years;Angiography;Animals;Anticoagulants;Anticoagulation;Arteries;Arteriovenous fistula;Arteriovenous malformation;Atrial Fibrillation;Biocompatible Materials;biomaterial compatibility;Biomedical Engineering;Blood;Blood capillaries;Brain;Bypass;Catheters;Central Nervous System;Circulation;Coagulation Process;comorbidity;Coupled;Data;Dimensions;Ensure;Etiology;Excision;experience;Extravasation;Family suidae;FDA approved;femoral artery;Formulation;Gel;Geometry;Hematology;Hemorrhage;Hemostatic Agents;Histologic;Human;Image;Immune response;Impairment;In Vitro;in vitro Model;in vitro testing;in vivo;Injectable;Injections;Label;Left;Liquid substance;Liver;Location;Lung;Mechanics;Medical;Methods;microCT;minimally invasive;Modeling;Modification;Morbidity - disease rate;mortality;Necrosis;Neurofibrillary Tangles;Operative Surgical Procedures;Patients;Pelvis;Performance;perfusion imaging;Persons;Physicians;polymerization;Polymers;Positioning Attribute;pressure;Prevalence;Property;Rattus;repaired;Resected;Risk;Risk Factors;Rodent;Roentgen Rays;Rupture;Safety;Series;Serology;Stress;Stretching;Structure;Symptoms;Testing;Therapeutic Effect;Therapeutic Embolization;Thinness;Time;ultrasound;Veins;Venous;Vertebral column;Visualization;Warfarin;Writing;X-Ray Computed Tomography

PROJECT_TITLE: Biomaterials for embolization and ablation of arterio-venous malformations

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Biotechnology

ORG_CITY: RICHARDSON

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF TEXAS DALLAS

PHR: PROJECT NARRATIVE More than a third of all known proteins that cells produce are secreted, but we fundamentally do not know how secreted proteins are assembled and processed due to the lack of appropriate biological systems and tools. The proposed research described here will (1) illuminate the molecular mechanisms our cells use to coordinate the assembly of secreted signaling protein complexes; and (2) build a library of novel proteases as a tool to dissect the function of secreted peptides derived from a single polyprotein, and as a potential therapeutic to degrade disease-causing proteins.

PI_NAMEs: DINGAL, POLIMYR CAESAR DAVE PELISCO (contact)

PROGRAM_OFFICER_NAME: PHILLIPS, ANDRE W

PROJECT_TERMS: Animal Behavior;Animals;arm;Behavior;Binding;Biochemical;biological systems;Blood;bone;cell type;Cells;Complex;Computer Models;Directed Molecular Evolution;Disease;Embryo;Endoderm;Evolution;Family;Genes;Goals;In Vitro;Libraries;Ligands;Mediating;Mesoderm;Molecular;Molecular Chaperones;Muscle;Nodal;novel;Peptide Hydrolases;Peptides;Physiological;Polyproteins;Process;programs;protein complex;Protein Precursors;Protein Secretion;Proteins;reconstitution;Research;secretion process;Signal Transduction;Signaling Protein;System;Therapeutic;Time;Tissues;tool;Transforming Growth Factor beta;Work

PROJECT_TITLE: Natural and synthetic mechanisms of ligand formation


NIH_SPENDING_CATS: Clinical Research;Eczema / Atopic Dermatitis;Genetics

ORG_CITY: BETHESDA

ORG_NAME: HENRY M. JACKSON FDN FOR THE ADV MIL/MED

ORG_STATE: MD

PHR: PROJECT NARRATIVE PI: Snow, Andrew L. The proposed research will better explicate the prevalence of pathogenic mutations in CARD11, BCL10, and MALT1 (CBM) in rare patients and common cohorts with allergic disease, and elucidate underlying intrinsic defects in lymphocyte function that contribute to pathology. Defining these mechanisms will help us better understand, predict, and potentially correct aberrant immune responses in atopic individuals with impaired CBM-dependent signaling in lymphocytes. Hence this research is highly relevant to research interests of the Division of Allergy, Immunology and Transplantation within NIAID, for which “the development, history, genetics, diagnosis, management and prevention” of allergic diseases is paramount.

PI_NAMEs: MILNER, JOSHUA D.;SNOW, ANDREW L (contact)

PROGRAM_OFFICER_NAME: DONG, GANG

PROJECT_TERMS: adaptive immune response;Affect;Allergic;Allergic Disease;allergic response;Antigen Receptors;Asthma;Atopic Dermatitis;atopy;Attenuated;Automobile Driving;B-Lymphocytes;BCL10 gene;Biochemical;Biochemical Pathway;Cell Line;Cell Physiology;Cell Signaling Process;Cell surface;Cells;Child;Chronic;clinical phenotype;Code;cohort;Collection;Communication;Complex;Coupled;cytokine;Data;Defect;Developed Countries;Development;Diagnosis;Diagnostic;Disease;Dominant-Negative Mutation;Eczema;Effector Cell;Essential amino acids supplementation;Food Hypersensitivity;gain of function mutation;Gene Mutation;Genes;Genetic;genetic analysis;Genetic Predisposition to Disease;genome wide association study;Glean;Glutamine;Heterozygote;Human;Hypersensitivity;IgE;Immune;Immune response;Immune System Diseases;Immunology;Impairment;In Vitro;in vivo;Individual;Infectious Skin Diseases;Inflammatory;innovation;insight;interest;Interferon Type II;Interleukin-13;Interleukin-4;Intervention;Investigation;Knowledge;Lesion;Leukocytes;Ligation;Link;Lymphocyte;Lymphocyte Activation;Lymphocyte Function;Lymphoma;Maintenance;MAPK8 gene;Metabolic Pathway;Molecular;Molecular Abnormality;Mucosa- associated lymphoid tissue lymphoma translocation protein-1;Mus;Mutant Strains Mice;Mutation;National Institute of Allergy and Infectious Disease;new therapeutic target;novel;null mutation;Pathogenesis;Pathogenicity;Pathology;Pathway interactions;Patients;Phenotype;Play;Population;Predisposition;Prevalence;Prevention;Process;Production;Proliferating;Proteins;Receptor Signaling;Recording of previous events;Research;Resources;Respiratory Tract Infections;Role;scaffold;Severe Combined Immunodeficiency;Signal Pathway;Signal Transduction;Signaling Protein;Skin;skin barrier;STAT3 gene;STAT5B gene;Structure;Supplementation;System;T cell differentiation;T-Cell Receptor;T-Lymphocyte;Testing;Therapeutic;tool;Transfection;Transplantation;treatment strategy;uptake;Validation;Variant;Work

PROJECT_TITLE: Mechanistic elucidation of pathogenic CBM complex mutations associated with atopic disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IIDB-K(57)]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Antimicrobial Resistance;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: NEW YORK

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: PROJECT NARRATIVE CRISPR-Cas systems influence bacterial evolution as barriers to horizontal gene transfer, but how they modulate bacterial virulence remains poorly defined. This proposal seeks to (1) investigate the molecular mechanisms by which CRISPR inhibits the dissemination of virulence gene-encoding Staphylococcus aureus Pathogenicity Islands (SaPIs) and (2) establish proof-of-concept for targeting SaPIs with CRISPR as a viable antimicrobial approach to reduce the burden of SaPI-harboring bacteria. Completion of this project will provide insight into the biological consequences of CRISPR on S. aureus virulence and lay the foundation for the development of virulence-targeting therapeutics to treat multidrug-resistant pathogens.

PI_NAMEs: BANH, DALTON VAN (contact)

PROGRAM_OFFICER_NAME: XU, ZUOYU

PROJECT_TERMS: adaptive immunity;Affect;Antibiotic Resistance;Antibiotics;antimicrobial;Antimicrobial Resistance;Automobile Driving;Bacteria;Bacterial Chromosomes;Bacterial Infections;Bacteriophages;Biological;Biological Assay;career;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;colonization resistance;commensal microbes;Communities;Complex;Data;design;Development;Disease;Doctor of Philosophy;Elements;Enterotoxins;Evolution;Excision;experimental study;Fellowship;Foundations;Genes;Genetic;genetic approach;Genetic Transcription;Genome;Genus staphylococcus;global health;Goals;Horizontal Gene Transfer;Immunity;Immunization;in vivo;Infection;insight;Institution;Invaded;Laboratories;Larva;Life Cycle Stages;Measures;Mediating;Medical;Mobile Genetic Elements;Modeling;Molecular;Multi-Drug Resistance;multi-drug resistant pathogen;Multiple Bacterial Drug Resistance;mutant;Nosocomial Infections;novel therapeutic intervention;nuclease;particle;pathogen;Pathogenesis;Pathogenicity Island;Physicians;Plasmids;Population;prevent;Principal Investigator;programs;reproductive;Research;resistance gene;Ribonucleases;RNA;Scientist;staphylococcal enterotoxin;Staphylococcus aureus;Superantigens;System;targeted treatment;Testing;Tetracycline Resistance;Therapeutic;Toxic Shock Syndrome;Toxin;Training;transmission process;Virulence;Virulence Factors;virulence gene;Virulent;Work

PROJECT_TITLE: Elucidating how CRISPR-Cas Modulates the Spread of S. aureus Pathogenicity Islands


NIH_SPENDING_CATS: Chronic Obstructive Pulmonary Disease;Lung;Pulmonary Hypertension;Rare Diseases

ORG_CITY: ALBUQUERQUE

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR

ORG_STATE: NM

PHR: PROJECT NARRATIVE  Chronic obstructive pulmonary diseases (COPD), including emphysema and chronic bronchitis, are established major causes of morbidity and mortality in the U.S. population. Such disease states cause poor oxygenation of the blood (hypoxia), and the resultant pulmonary hypertension [World Health Organization (WHO) Group 3 class of pulmonary hypertension] can lead to right heart failure. Similar clinical manifestations are common in patients with severe pulmonary arterial hypertension (PAH; WHO Group 1), a rare and progressive disease that is usually fatal if untreated. The planned studies are relevant to the mission of the NHLBI and the National Center on Sleep Disorders Research because they will mechanistically examine the contribution of a novel intracellular signaling pathway to pulmonary hypertension in animal models of COPD and severe PAH and have potential to reveal new therapeutic targets for treatment of these disorders.

PI_NAMEs: RESTA, THOMAS C (contact)

PROGRAM_OFFICER_NAME: SUTLIFF, ROY L

PROJECT_TERMS: Acute;Agonist;Airway Disease;Altitude;Animal Model;arterial remodeling;Blood;caveolin 1;Cell membrane;Cell model;Cell Proliferation;Cholesterol;Cholesterol Homeostasis;cholesterol trafficking;Chronic;Chronic Bronchitis;Chronic Obstructive Pulmonary Disease;Clinical;constriction;Couples;Coupling;Data;Disease;Distal;Edema;effective therapy;Electron Transport;Epidermal Growth Factor Receptor;Functional disorder;G-Protein-Coupled Receptors;Generations;genetic approach;Heart;human model;Hypoxia;hypoxia-induced pulmonary hypertension;Impairment;innovation;Knowledge;Laboratories;Link;Lung;Lung Diseases;lung hypoxia;Maintenance;Mechanics;Mediating;Membrane;Microfilaments;Mission;Mitochondria;mitochondrial dysfunction;mitochondrial membrane;Morbidity - disease rate;mortality;Mus;NADPH Oxidase;National Heart, Lung, and Blood Institute;new therapeutic target;novel;novel strategies;novel therapeutic intervention;Oxidants;Pathway interactions;Patients;Peripheral;pharmacologic;Pilot Projects;Population;Preparation;Preventive measure;Process;Production;Progressive Disease;Proliferating;pulmonary arterial hypertension;Pulmonary arterial remodeling;Pulmonary Circulation;Pulmonary Emphysema;Pulmonary Heart Disease;Pulmonary Hypertension;pulmonary vascular disorder;pulmonary vasoconstriction;Rare Diseases;Reactive Oxygen Species;Regulation;Research;response;right ventricular failure;Rodent Model;Role;Scaffolding Protein;Signal Pathway;Signal Transduction;Sleep Apnea Syndromes;Sleep Disorders;Smooth Muscle Myocytes;Source;src-Family Kinases;Stimulus;Stretching;Testing;Tissue Model;uptake;Vascular Diseases;Vascular resistance;vasoconstriction;Vasoconstrictor Agents;World Health Organization

PROJECT_TITLE: Oxidant Signaling in Pulmonary Hypertension

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-RCCS-Q(03)]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: Nashville

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: Nurr1 is a transcription factor implicated as a therapeutic drug target in aging-associated neurodegenerative and dementia disorders characterized by a loss of neuron function including including Parkinson's and Alzheimer's diseases. Little is known mechanistically how Nurr1 is regulated by drug-like small molecules, a knowledge gap that we aim to resolve as a long-term goal of this project. Successful outcomes from our work will aid in the rational design of novel Nurr1 therapeutics.

PI_NAMEs: KOJETIN, DOUGLAS  (contact)

PROGRAM_OFFICER_NAME: YANG, AUSTIN JYAN-YU

PROJECT_TERMS: abeta accumulation;Adjuvant;Affect;age related neurodegeneration;aging related;Agonist;Alzheimer's Disease;Alzheimer's disease model;Amyloid beta-Protein;Animal Model;antagonist;Binding;Biochemical;Biological Assay;Brain;brain tissue;Cell model;Cells;Cellular Assay;Chemicals;Complex;Coupled;crosslink;Data;Dementia;design;Deuterium;Development;Disease;Dissociation;Docosahexaenoic Acids;dopaminergic neuron;Drug Targeting;Endocannabinoids;Excretory function;Genetic Transcription;Goals;Heterodimerization;Homeostasis;Hydrogen;improved;Knowledge;Ligand Binding;Ligand Binding Domain;Ligands;Maintenance;Mass Spectrum Analysis;Molecular;Molecular Conformation;monomer;Movement;multidisciplinary;Nerve Degeneration;neuroinflammation;neuron loss;Neurons;neuroprotection;new therapeutic target;NMR Spectroscopy;novel;NR4A2 gene;Nuclear Orphan Receptor;Nuclear Receptors;Outcome;Parkinson Disease;Pathogenesis;permissiveness;Pharmaceutical Preparations;PPAR gamma;Publishing;rational design;Regulation;Reporting;Repression;Roentgen Rays;RXR;small molecule;Specificity;structural biology;Structure;Surface;Therapeutic;Therapeutic Agents;Thyroid Hormones;Tissues;transcription factor;Unsaturated Fatty Acids;Work;X-Ray Crystallography

PROJECT_TITLE: Molecular basis of activation of the orphan nuclear receptor Nurr1

STUDY_SECTION: BPNS

STUDY_SECTION_NAME: Biophysics of Neural Systems Study Section[BPNS]


ORG_CITY: WINSTON-SALEM

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

PHR: This renewal application requests funds to continue a predoctoral Program for graduate training in Immunology and Pathogenesis. The goal of this long standing Program is to provide value added training to prepare students for productive careers in academia, industry, or other science-related careers.

PI_NAMEs: ALEXANDER-MILLER, MARTHA ANN (contact)

PROGRAM_OFFICER_NAME: SASTALLA, INKA I

PROJECT_TITLE: Training Program in Immunology and Pathogenesis

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases B Research Study Section[MID-B]


NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Heart Disease;Nanotechnology;Neurosciences;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE: Cardiac action potentials are crucial for their physiological functions in the human heart. This proposal aims to develop an electrophysiology platform that enables robust, scalable and long-term monitoring of cardiac action potentials. The instrument to be developed will bring new capabilities to end users in both academia and industry.

PI_NAMEs: CUI, BIANXIAO  (contact)

PROJECT_TERMS: 3-Dimensional;Academia;Action Potentials;Adopted;Affect;Amplifiers;Biomedical Research;Cardiac;Cardiac Myocytes;Cardiotoxicity;Cell membrane;Cells;Chemistry;Chronic;Communities;Coupled;Custom;Data;design;Detection;Development;Diagnosis;drug mechanism;Drug Screening;Electrodes;Electrophysiology (science);Electroporation;extracellular;fabrication;flexibility;frontier;Funding Opportunities;Goals;Heart;Heart Atrium;heart function;Human;human pluripotent stem cell;improved;In Situ;Incubators;Industrialization;Industry;industry partner;instrument;interest;Ion Channel;Manuals;Measurement;Mediating;Membrane;Methods;miniaturize;minimally invasive;Monitor;monolayer;nanoelectrode array;Nature;Neurons;Nodal;Organoids;patch clamp;Patch-Clamp Techniques;Performance;Pharmaceutical Preparations;Pharmacologic Substance;Physiologic pulse;Physiological;pre-clinical;Process;Relaxation;Research;Research Personnel;Risk;screening;solid state;stem cell technology;stem cells;System;Techniques;Technology;three dimensional structure;Time;tool;Translating;Translations;usability;Ventricular;voltage

PROJECT_TITLE: An electrophysiology platform that enables robust, scalable and long-term intracellular recording of cardiomyocytes

STUDY_SECTION: ISD

STUDY_SECTION_NAME: Instrumentation and Systems Development Study Section[ISD]


NIH_SPENDING_CATS: Cancer;Cervical Cancer;Clinical Research;HIV/AIDS;Infectious Diseases;Prevention;Sexually Transmitted Infections;Women's Health Research

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative HIV infection leads to persistent immune activation and T cell exhaustion in the circulation and intestinal mucosa, though this has largely been studied in men. Globally, more than half of all people living with HIV are women and girls, and there is an increased severity and frequency of many female genital tract disorders associated with HIV infection (e.g. persistent HPV, cervical cancer, bacterial vaginosis, HSV reactivation), highlighting an important gap in our understanding of how HIV impacts immunity in women in both the circulation and female genital tract tissues. Here, we propose to profile T cell activation and exhaustion in the circulation and female genital tract of women with HIV, leveraging a well-characterized cohort of women in Mombasa, Kenya.

PI_NAMEs: LUND, JENNIFER M;MCCLELLAND, RAYMOND SCOTT (contact)

PROGRAM_OFFICER_NAME: RUSSO, DENISE

PROJECT_TERMS: acquired immunity;Acquired Immunodeficiency Syndrome;Affect;Antigens;antiretroviral therapy;B-Lymphocytes;Bacterial Vaginosis;Biological Assay;Blood;CD4 Positive T Lymphocytes;Cell Compartmentation;Cell Surface Proteins;Cells;Cervical;cervical biopsy;Cessation of life;chemokine;Chronic;chronic infection;circulating biomarkers;Circulation;Clinical;Cohort Analysis;cost;Country;cytokine;Data;Diagnosis;Disease;Disease Progression;effective therapy;Enrollment;Epidemic;exhaust;exhaustion;Face;Female;female reproductive tract;female reproductive tract infection;Flow Cytometry;Frequencies;Functional disorder;genital infection;Genitalia;girls;Goals;Health;HIV;HIV diagnosis;HIV Infections;HIV Seropositivity;Human papilloma virus infection;Human Papilloma Virus Vaccine;Human Papillomavirus;Immune;immune activation;Immune System Diseases;Immunity;Immunologic Surveillance;immunological status;Immunology;immunoregulation;Impairment;improved;Incidence;Individual;Inflammatory;inflammatory marker;Interruption;Intervention;Intestinal Mucosa;Investigation;Kenya;Lymphocytic choriomeningitis virus;Malignant neoplasm of cervix uteri;Measures;Mediating;men;Morbidity - disease rate;mortality;Mucous Membrane;Newly Diagnosed;novel strategies;Outcome;pathogen;Pathway interactions;Persons;Pharmaceutical Preparations;Phenotype;Predisposition;Prevalence;Prevention;preventive intervention;programmed cell death protein 1;Proliferating;Proxy;Regulatory T-Lymphocyte;Reporting;Research;Risk;Sampling;Severities;sex;Sex Distribution;Simplexvirus;single cell analysis;Site;standard of care;T cell response;T-Cell Activation;T-Lymphocyte;Testing;Tissues;tumor;uptake;Viral;viral rebound;Virus Diseases;Virus Replication;Vulvovaginal Candidiasis;Woman;Women's cohort;Women's Health;Work

PROJECT_TITLE: T-cell activation and exhaustion in the HIV-positive female genital tract

STUDY_SECTION: HIVD

STUDY_SECTION_NAME: HIV Immunopathogenesis and Vaccine Development Study Section[HIVD]


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Biomedical Imaging;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Digestive Diseases;Neurosciences;Pain Research

ORG_CITY: CHARLESTOWN

ORG_NAME: SPAULDING REHABILITATION HOSPITAL

PHR: PROJECT NARRATIVE Somatosensory autonomic reflexes, which allow stimulation at specific body regions to modulate physiologic response at distant sites, have been linked to acupuncture and acupoint specificity, a particularly relevant concept for the modulation of the gastrointestinal (GI) tract. In this proposal, we will apply advanced, non-invasive imaging approaches to comprehensively investigate acupoint-specific effects on central (brainstem) and peripheral (gastric) function, as well as placebo/nocebo effects generated by expectancy manipulation, in patients with functional dyspepsia (FD). Our study will answer an important translational neuroscience question as to whether rodent acupoint specific responses generalize to humans, and will offer new insights into the role of expectancy for cutaneous stimulation as a therapeutic option for FD.

PI_NAMEs: SCLOCCO, ROBERTA  (contact)

PROGRAM_OFFICER_NAME: CHEN, WEN G

PROJECT_TERMS: Abdomen;Acupuncture Points;Acupuncture Therapy;Adrenal Glands;Afferent Neurons;Anatomy;Animal Model;Anti-Inflammatory Agents;Atmosphere;autonomic reflex;Award;Biomedical Engineering;biomedical imaging;Body Regions;Brain;brain magnetic resonance imaging;Brain Stem;Breathing;career;career development;Cell Nucleus;Cine Magnetic Resonance Imaging;Clinical;clinical efficacy;clinical translation;Conduct Clinical Trials;contextual factors;contrast enhanced;Cutaneous;Data;Diagnosis;disorders of gut-brain interaction;Dissociation;Distant;dorsal motor nucleus;Dyspepsia;Efferent Neurons;Electroacupuncture;Ensure;Environment;Expectancy;expectation;Fascia;Food;Four-dimensional;Functional Magnetic Resonance Imaging;Gastroenterology;gastrointestinal;Gastrointestinal Diseases;gastrointestinal symptom;Gastrointestinal tract structure;Goals;gut-brain axis;Health;Hindlimb;Hospitals;Human;Image;imaging approach;insight;Institution;Intake;Integrative Medicine;Intervention;kinematics;Leg;Link;Location;Longitudinal Studies;Magnetic Resonance Imaging;Mediating;medical schools;Mentors;Mentorship;Motility;motility disorder;multidisciplinary;nerve supply;neural circuit;Neuroanatomy;neuroimaging;neuroregulation;non-invasive imaging;Nonpharmacologic Therapy;Nucleus solitarius;Outcome;Pain;Pathway interactions;Patient Self-Report;Patients;Peripheral;Peristalsis;Physiological;Physiology;Pilot Projects;Placebo Effect;Placebos;psychological outcomes;Publications;Publishing;Randomized;Rehabilitation therapy;Research;Research Personnel;Resolution;response;Response Generalization;Rodent;Rodent Model;Role;Site;skills;somatosensory;spatiotemporal;Specificity;Stomach;success;Supervision;Symptoms;Technical Expertise;Therapeutic;tool;Training;translational neuroscience;Translational Research;translational research program;Upper digestive tract structure;Visceral;Work

PROJECT_TITLE: Body Region Specificity for Neuromodulation of the Gut-Brain Axis in Functional Dyspepsia


ED_INST_TYPE: OTHER SPECIALIZED SCHOOLS

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Estrogen;Menopause;Neurodegenerative;Neurosciences;Women's Health Research

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

ORG_STATE: CA

PHR: Project Narrative Women make up two-thirds of Alzheimer’s disease (AD) cases in the US, and, once diagnosed, have steeper rates of episodic memory decline, the hallmark clinical symptom of AD. Despite the established greater risk in women, models of AD pathogenesis have not adequately accounted for such a sex difference. This project proposes and investigates a GABAergic model in humans, testing the impact of sex on GABA, brain activity, and episodic memory in middle-aged and older adults at genetic risk for developing AD.

PI_NAMEs: EICH, TEAL S (contact)

PROGRAM_OFFICER_NAME: WAGSTER, MOLLY V

PROJECT_TERMS: abeta accumulation;Accounting;Affect;Age;age related;Aging;Alleles;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease risk;American;Amyloid beta-Protein;Animal Experimentation;Animals;apolipoprotein E-4;Apolipoproteins;Area;Behavioral;Biological Assay;Brain;Brain imaging;Clinical;Clinical Trials;Cognitive;Communities;Dementia;Development;Diagnosis;Disparity;Disproportionately impacts women;Elderly;Episodic memory;episodic memory impairment;Estradiol;Estrogen decline;Estrogens;Event;Female;Functional disorder;gamma-Aminobutyric Acid;Genetic Risk;genetic risk factor;Gonadal Steroid Hormones;hippocampal pyramidal neuron;Hippocampus;Hormones;Human;human female;human male;human model;Hyperactivity;Impaired cognition;Impairment;improved;Individual;Individual Differences;Inhibitory Synapse;Interneurons;Intervention;late life;life span;male;Mediating;Memory;memory consolidation;Memory impairment;Memory Loss;men;Menopause;middle age;Modeling;Morphology;neural model;Neurobehavioral Manifestations;Neurobiology;Neurodegenerative Disorders;Neurons;neurotoxicity;new therapeutic target;older adult;Pathogenesis;Pathology;Pattern;Perimenopause;Play;Positron-Emission Tomography;Postmenopause;precision medicine;Premenopause;Progesterone;Quality of life;receptor;Risk;Role;Sampling;sex;Sex Differences;steroid hormone;symposium;Symptoms;System;Techniques;Testing;theories;Woman;Work

PROJECT_TITLE: The role of sex in GABAergic-mediated, Alzheimer’s disease-related episodic memory impairments from mid to late life


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Clinical Research;Digestive Diseases;Food Allergies

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

PHR: PROJECT NARRATIVE Eosinophilic esophagitis (EoE) is an allergic disease of the esophagus partially mediated by epithelial barrier breach, resulting in normally harmless antigens penetrating the underlying tissues, encountering immune cells, and initiating allergic responses. We uncovered that the low-density lipoprotein receptor–related protein 1 (LRP1) is responsible for shutting down pro- inflammatory signaling pathways and promoting epithelial homeostasis and that LRP1 is under excessive processing during EoE. We suggest that LRP1 is a therapeutic target in EoE.

PI_NAMEs: AZOUZ, NURIT P (contact)

PROGRAM_OFFICER_NAME: GREENWEL, PATRICIA

PROJECT_TERMS: Affect;Agonist;Allergens;Allergic;Allergic Disease;allergic response;Anti-Inflammatory Agents;Antigens;Antiinflammatory Effect;Attenuated;Binding;Biopsy;C-terminal;Calpain;Caspase;Cells;Child;Childhood;Chronic;Complex;Deglutition Disorders;Dependence;Detergents;Development;Disease;encryption;Environment;Enzymes;Eosinophilia;Eosinophilic Esophagitis;Epithelial Cells;Epithelium;Equation;Equilibrium;Esophageal Diseases;Esophagus;Etiology;Food;Foundations;Functional disorder;Gene Expression;Genes;genetic signature;Genetic Transcription;Goals;Homeostasis;human subject;Immune;Immune Tolerance;Immunity;improved;In Vitro;in vivo;Individual;Inflammation;Inflammatory;Inflammatory Response;insight;Interleukin-13;Knockout Mice;Knowledge;LDL-Receptor Related Protein 1;Length;Ligands;Lipoprotein Receptor;Location;Mediating;Mediator;Modeling;Molecular;Molecular Weight;mouse model;Nuclear;Pain;Pathogenesis;Pathology;Patients;Penetration;Peptide Hydrolases;Peptides;Pharmaceutical Preparations;Phenotype;Phosphorylation;Physiological;Play;pre-clinical;preservation;Process;Production;Protease Inhibitor;Proteins;Quality of life;Reaction;receptor mediated endocytosis;Resolution;response;Role;scavenger receptor;Series;Serine Proteinase Inhibitors;Serpins;Signal Pathway;Signal Transduction;Site;small molecule inhibitor;STAT6 gene;Stimulus;Testing;Therapeutic;Therapeutic Effect;therapeutic target;Tissues;Translating;TSLP gene

PROJECT_TITLE: The role of serpins and LRP1 in the esophageal epithelium during eosinophilic esophagitis

STUDY_SECTION: DNPD

STUDY_SECTION_NAME: Digestive and Nutrient Physiology and Diseases Study Section [DNPD]


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Gene Therapy;Genetics;Immunotherapy;Lung;Lung Cancer

ORG_CITY: TAMPA

ORG_NAME: H. LEE MOFFITT CANCER CTR & RES INST

PHR: PROJECT NARRATIVE Advances in cancer immunotherapies have improved survival of patients with several types of cancers. However, many patients do not receive any significant clinical benefit from current immunotherapies. In this study, we will test the mechanism of action of a newly developed immune stimulatory agent in laboratory studies and on immune cells in patient tumors along with the ability to generate antitumor responses.

PI_NAMEs: BEG, AMER AZIZ (contact)

PROGRAM_OFFICER_NAME: SOMMERS, CONNIE L

PROJECT_TERMS: Agonist;Antitumor Response;Biopsy;Blood;cancer cell;cancer immunotherapy;Cancer Patient;cancer therapy;cancer type;CD40 Ligand;CD8-Positive T-Lymphocytes;Cell surface;cell type;Cells;Clinical;clinical development;Clinical Research;Clinical Trials;conditionally replicative adenovirus;Cross-Priming;Cytolysis;Dendritic cell activation;Dendritic Cells;Development;Dose;draining lymph node;effector T cell;Engineering;falls;FDA approved;first-in-human;gain of function;Generations;Genetic Transcription;Goals;Growth;Human;IFNAR1 gene;Immune;immune activator;Immune checkpoint inhibitor;immune stimulatory agent;Immunity;Immunotherapy;improved;In Situ;Inflammatory;Injections;insight;Interferons;Knockout Mice;Laboratory Study;Lead;loss of function;Lung Neoplasms;Malignant neoplasm of lung;Malignant Neoplasms;Melanoma;Melanoma Tumor;Membrane;Memory;migration;Modality;Modeling;mouse model;Mus;Natural Immunity;neoantigens;neoplastic cell;Non-Small-Cell Lung Carcinoma;Normal Cell;novel;oncolytic adenovirus;Oncolytic viruses;participant enrollment;Pathway interactions;Patients;Phase;preclinical study;programs;Refractory;Resources;response;Signal Transduction;Solid;Solid Neoplasm;stem;synergism;T cell receptor repertoire sequencing;T cell response;T-Cell Activation;T-Lymphocyte;targeted treatment;Testing;Therapeutic;TNFRSF5 gene;Toxic effect;trafficking;tumor;tumor growth;Tumor Immunity;tumor microenvironment;Up-Regulation;Validation;Viral Physiology

PROJECT_TITLE: Defining impact of in situ activation of CD40 and type 1 interferon signaling on theTME and systemic T cell immunity in murine models and cancer patients

STUDY_SECTION: TIO

STUDY_SECTION_NAME: Translational Immuno-oncology Study Section[TIO]