NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_DEPT: OPHTHALMOLOGY

PHR: PROJECT NARRATIVE: Rod and cone photoreceptor cells die-off in multiple diseases, causing permanent vision loss. A comprehensive understanding of how multipotent progenitor cells choose to become photoreceptors versus other neurons is needed to enable audacious new regenerative therapies to restore vision through rod and cone replacement. To determine how the nascent retina generates photoreceptors and related neuronal cell types, the investigators perform a combination of genetic, molecular, and developmental experiments in mice.

PI_NAMEs: BRZEZINSKI, JOSEPH A (contact)

PROGRAM_OFFICER_NAME: FORTRESS, ASHLEY

PROJECT_TERMS: 3-Dimensional;Age related macular degeneration;American;Architecture;Blindness;Cell Cycle;Cell Fate Control;cell fate specification;cell type;Cells;chromosome conformation capture;Clustered Regularly Interspaced Short Palindromic Repeats;Compensation;Competence;Cone;CRISPR interference;CRISPR/Cas technology;Data;Development;Disease;DNA;Dominant-Negative Mutation;Enhancers;Equilibrium;Event;experimental study;Face;Gene Expression;gene regulatory network;Genes;Genetic;genetic approach;Genetic Enhancer Element;Genome;Goals;Human;Impairment;Individual;Interneurons;Knowledge;loss of function;Methods;Molecular;Multipotent Stem Cells;Mus;Mutagenesis;mutant;Mutant Strains Mice;Mutate;Natural regeneration;Neurons;Other Genetics;Persons;Photoreceptors;Physiologic pulse;Population;prevent;progenitor;promoter;regenerative approach;regenerative therapy;Regulation;Regulatory Element;Research Personnel;Resolution;Retina;Retinal Cone;Retinal Diseases;retinal progenitor cell;Rod;sight restoration;Source;stem cells;Testing;Therapeutic;three dimensional structure;Time;tool;transcription factor;Transplantation;Undifferentiated;Untranslated RNA;Vertebrate Photoreceptors;Visual impairment

PROJECT_TITLE: Mechanisms of cell fate specification and competence regulation in photoreceptors


ADMINISTERING_IC: CA

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: BOSTON

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: Narrative  Accurate insertion of a thin, long needle is crucial for successful biopsy and focal treatment of prostate cancer, though it is a challenging task for physicians as the needle can be easily deflected from the target due to bending in the tissue. This project aims to improve needle placement accuracy by developing a novel shape- sensing needle and needle-guiding manipulator, which adaptively compensates for deflection while a physician inserts a needle. These new technologies will reduce the error in targeting abnormal lesions with the needle and improve outcomes of prostate biopsy and focal treatment.

PI_NAMEs: HATA, NOBUHIKO ;IORDACHITA, IULIAN IOAN;TOKUDA, JUNICHI  (contact)

PROGRAM_OFFICER_NAME: BEIER, HOPE THOMAS

PROJECT_TERMS: 3D Print;Achievement;Address;Algorithms;Anatomy;Biopsy;Calibration;cancer care;Clinical;clinical practice;clinical translation;Collaborations;Compensation;Complex;Core Biopsy;Data;design;Development;Devices;Diagnosis;Effectiveness;Feedback;Fiber;Freedom;image guided;improved;improved outcome;in vivo;Intervention;Knowledge;Lesion;Location;machine learning model;Magnetic Resonance Imaging;Malignant neoplasm of prostate;Manuals;Measures;Mechanics;Methods;model design;Molds;Needles;new technology;novel;optical fiber;optimal treatments;Outcome;Patients;phantom model;Phase;Physicians;Play;porcine model;predictive modeling;Procedures;Process;Prostate;prostate biopsy;Prostate Cancer therapy;Research;Role;Safety;sensor;Shapes;Structure;success;System;Technology;Testing;Thinness;Time;Tissue Sample;Tissues;Training;Translating;Treatment outcome;United States;Validation;Work

PROJECT_TITLE: Adaptive Percutaneous Prostate Interventions using Sensorized Needle

STUDY_SECTION: IGIS

STUDY_SECTION_NAME: Imaging Guided Interventions and Surgery Study Section[IGIS]


ED_INST_TYPE: SCHOOLS OF MEDICINE

NIH_SPENDING_CATS: Breast Cancer;Cancer;Genetics;Women's Health Research

ORG_CITY: IOWA CITY

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Project Narrative  This project aims to elucidate how a poorly studied CTLH E3 ubiquitin ligase targets the epigenetic tumor suppressor SNF5 to drive breast cancer development and drug response. This study has the potential to uncover novel therapies that overcome drug resistance and prevent tumor recurrence.

PI_NAMEs: CHEN, SONGHAI  (contact);WEIGEL, RONALD J

PROGRAM_OFFICER_NAME: LUO, RUIBAI

PROJECT_TERMS: Automobile Driving;breast cancer progression;Breast Carcinoma;cancer initiation;cancer therapy;Cell Line;clinically relevant;Complex;Data;Development;Drug resistance;Effectiveness;Enhancers;Epigenetic Process;ERBB2 gene;G Protein-Coupled Receptor Signaling;G-Protein-Coupled Receptors;Gene Deletion;Genetic;Genetic Transcription;Glucose;Go Alpha Subunit;Growth;GTP-Binding Proteins;improved;Knowledge;lapatinib;Malignant Breast Neoplasm;mammary;Mammary Neoplasms;Mediating;Metastatic Neoplasm to the Lung;Modeling;molecular subtypes;mouse model;Neoplasm Metastasis;neoplastic cell;new therapeutic target;novel;novel therapeutics;Nuclear;Nuclear Translocation;Oncogenic;Orthologous Gene;overexpression;Pathway interactions;patient derived xenograft model;Pharmaceutical Preparations;PI3K/AKT;prevent;Prognosis;programs;Proteins;recruit;Recurrent tumor;Resistance;response;Role;scaffold;Scaffolding Protein;Signal Transduction;Signaling Protein;SMARCB1 gene;SRC gene;Subgroup;targeted treatment;Testing;therapy resistant;Transgenic Mice;Trastuzumab;tumor;tumor growth;tumor initiation;tumor progression;Tumor Promotion;Tumor Suppressor Proteins;tumorigenesis;tumorigenic;Ubiquitin;ubiquitin ligase;ubiquitin-protein ligase;Ubiquitination;Up-Regulation;Yeasts

PROJECT_TITLE: Role of the CTLH E3 ubiquitin ligase in breast cancer progression

STUDY_SECTION: BCO

STUDY_SECTION_NAME: Biochemical and Cellular Oncogenesis Study Section[BCO]


ADMINISTERING_IC: GM

ED_INST_TYPE: UNIVERSITY-WIDE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding

ORG_CITY: HAMPTON

ORG_NAME: HAMPTON UNIVERSITY

ORG_STATE: VA

PHR: The acquisition of Time of Flight -Mass Spectrometer will invigorate biomedical research in Hampton University. In addition, the student in degree program in Pharmaceutical Sciences and other biomedical related area will benefit from a hand on research-based education from this instrument, and that will contribute to our institutional mission in increasing the talent pool from underrepresented minority on which the U.S. biomedical research enterprise can draw. Project Narrative

PI_NAMEs: DU, CHENGAN  (contact)

PROGRAM_OFFICER_NAME: BECKETT, DOROTHY

PROJECT_TERMS: Address;Advisory Committees;Area;Award;Bachelor's Degree;Behavioral;Biomedical Research;career;Clinical;Collaborations;Data;Dedications;Degree program;disparity reduction;Education;Enrollment;Equipment;faculty research;Funding;Germination;Goals;hands on research;Human Resources;Individual;innovation;Institution;instrument;Laboratories;Maintenance;mass spectrometer;Mission;molecular mass;Nature;operation;Outcome;Pharmacologic Substance;Productivity;programs;Protocols documentation;Publications;Research;Research Activity;Research Personnel;Research Proposals;Resolution;Science;Scientist;Students;success;Talents;Time;Training;Underrepresented Minority;Universities;web site

PROJECT_TITLE: Time-of -Flight Mass Spectrometer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CDB-L (30)]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Childhood Injury;Infectious Diseases;Maternal Health;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Women's Health Research

ORG_CITY: PORTLAND

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE Premature birth is a significant obstetrical problem that is associated with fetal brain injury and a high risk of later-life neurological and behavioral deficits. This proposal will expand our understanding antibiotic treatment of premature labor and mechanisms of fetal neuroinflammation in response to intrauterine Ureaplasma infection that causes premature birth.

PI_NAMEs: KELLEHER, MEREDITH ANNE (contact)

PROGRAM_OFFICER_NAME: GIRARDI, GUILLERMINA

PROJECT_TERMS: 16S ribosomal RNA sequencing;Amniotic Fluid;animal data;Animal Model;antenatal;Antibiotic Therapy;Antibiotics;antimicrobial;Astrocytes;Azithromycin;Behavioral;Birth;Blood;Blood flow;Brain;Cardiac;Catheterization;Cell Culture Techniques;Cells;Central Nervous System;Cerebellum;Cerebral Palsy;Cervical Ripening;chemokine;Chronic;Clinical Management;clinically relevant;Cognitive deficits;Complex;cytokine;Data;Detection;Development;diagnostic technologies;Diagnostic tests;diagnostic tool;digital;Discipline of obstetrics;Dose;Enzyme-Linked Immunosorbent Assay;Etiology;Evaluation;experience;Exposure to;extracellular vesicles;fetal;fetal blood;fetal brain injury;Fetal Lung;Fetal Membranes;Fetal Monitoring;Fetus;Gestational Age;glial activation;Gliosis;gray matter;Health;hemodynamics;high risk;Hippocampus;Histologic;Human;human data;Hyaluronic Acid;Hypoxia;Immune;immune modulating agents;Immune response;Immunologics;Immunology;improved;In Vitro;in vivo;in vivo monitoring;Infection;Inflammasome;Inflammation;Inflammation Mediators;Inflammatory Response;Injury;Interleukins;intraamniotic infection;intrauterine infection;intrauterine inflammation;intraventricular hemorrhage;late life;Lesion;Macaca mulatta;maternal serum;Mediating;Membrane;Microglia;MicroRNAs;Modeling;Molecular;Monitor;Mothers;Myelin;myelination;nano-string;Neonatal;neonate;neural;neurodevelopment;Neurodevelopmental Impairment;Neuroglia;neuroinflammation;Neurologic;Neurologic Effect;Neurological outcome;Neuronal Injury;Neurons;nonhuman primate;noninvasive diagnosis;novel;novel diagnostics;oligodendrocyte lineage;Oligodendroglia;Outcome;Patients;Perinatal Brain Injury;Phenotype;Physiologic Monitoring;Physiological;Physiology;Placenta;placental membrane;polarized cell;Pregnancy;pregnant;premature;Premature Birth;Premature Infant;Premature Labor;Premature Rupture Fetal Membranes;preterm premature rupture of membranes;Prostaglandins;protein expression;Proteins;Proteomics;Regimen;reproductive tract;response;Risk;Role;Safety;Sampling;Sensory;Serum;Signal Transduction;synaptogenesis;Techniques;Testing;Therapeutic;Transcript;transcriptomics;Treatment Efficacy;treatment response;ultrasound;Ureaplasma;Ureaplasma Infections;Ureaplasma parvum;uterine contractility;vaginal microbiome;Ventricular;Virulence;Virus Diseases;white matter

PROJECT_TITLE: Neuroinflammation in response to ascending reproductive tract ureaplasma infection

STUDY_SECTION: PN

STUDY_SECTION_NAME: Pregnancy and Neonatology Study Section[PN]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Biotechnology;Eye Disease and Disorders of Vision;Genetics;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

ORG_STATE: CA

PHR: Project Narrative Age-Related meibomian gland dysfunction (ARMGD) is a common eyelid disorder having a widespread prevalence of 39-50% in the US population and is a major cause of evaporative dry eye disease in the aging population. Our studies suggest a 'meibocyte centric' hypothesis for the development of ARMGD involving mechanisms that regulate meibocyte stem/progenitor cell renewal and differentiation lead to acinar atrophy, while only secondarily affecting the ductal epithelium. 1) That direct loss of Pparg signaling leads to an age and sex dependent loss of meibocyte differentiation, acinar atrophy and dry eye disease; 2) That Pparg signaling transcriptionally regulates meibocyte differentiation that when lost leads to up-regulation of ductal epithelial differentiation in progenitor meibocytes; 3) That loss of meibocyte progenitor cells recapitulates loss of Pparg leading to loss of meibocyte differentiation, acinar atrophy, and dry eye disease.

PI_NAMEs: JESTER, JAMES V (contact)

PROGRAM_OFFICER_NAME: MCKIE, GEORGE ANN

PROJECT_TERMS: 3-Dimensional;Ablation;Acinus organ component;Address;Affect;Age;age effect;age related;age related changes;Aging;aging population;aqueous;Atrophic;Cell Culture Techniques;Cells;ChIP-seq;Cholesterol Esters;clinical biomarkers;conditional knockout;Confusion;Cornea;design;Development;differential expression;Disease Management;Down-Regulation;Dropout;Dry Eye Syndromes;Dryness;Duct (organ) structure;Ductal Epithelial Cell;Ductal Epithelium;Epithelial Cells;Esters;evaporation;Event;Excretory function;experimental study;Eye;eye dryness;Eyelid Diseases;Eyelid structure;Female;Film;Fluorescein;Gene Expression Profile;Genes;Genetic Transcription;Gland;Goals;Growth Factor;Homeostasis;Human;immunocytochemistry;Incidence;Individual;inducible Cre;Inflammation;keratin 5;knock-down;Knockout Mice;Knowledge;Label;Lead;Lipids;male;meibomian gland;meibomian gland dysfunction;Methods;Molecular;Mus;Natural regeneration;novel strategies;novel therapeutics;Nuclear Receptors;ocular surface;Ophthalmologist;Optometrist;palliative;Patients;Pharmaceutical Preparations;Population;PPAR gamma;Prevalence;progenitor;Progress Reports;Proliferating;Regulation;Reporting;research clinical testing;self-renewal;sex;Signal Transduction;single cell ATAC-seq;spheroids;Stains;stem;stem cell biomarkers;stem cell division;stem cell population;stem cells;Surface;System;Tamoxifen;Tarsal plate;Telomerase;Testing;Time;Transcriptional Regulation;transcriptomics;Transgenic Mice;Up-Regulation;Waxes;Western Blotting

PROJECT_TITLE: Age-Related Meibomian Gland Dysfunction

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: SAINT LOUIS

ORG_DEPT: GENETICS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative:  Diseases like diabetic and chemotherapy-induced peripheral neuropathy, and Amyotrophic lateral sclerosis (ALS), involve the dysfunction and loss of axons, connections with the spinal cord that allow for muscle control and sensation. The cellular machinery that regulates axon destruction also affects nerve inflammation, which contributes to disease. We will explore the relationships between this machinery and cells that participate in inflammation with a goal of developing disease treatments.

PI_NAMEs: DIANTONIO, AARON ;MILBRANDT, JEFFREY D (contact)

PROGRAM_OFFICER_NAME: GUBITZ, AMELIE

PROJECT_TERMS: ABHD12 gene;Acceleration;Acute;Address;Affect;Amyotrophic Lateral Sclerosis;Anti-Inflammatory Agents;Apoptotic;Automobile Driving;Axon;axon injury;axonal degeneration;cell dedifferentiation;cell injury;Cells;Charcot-Marie-Tooth Disease;chemokine;Chemotactic Factors;Chemotherapy-induced peripheral neuropathy;Chronic;CX3CR1 gene;Development;diabetic;Disease;disease model;Disease Progression;early onset;Eating;Esthesia;Excision;experimental study;Exposure to;Extracellular Matrix Proteins;Failure;Functional disorder;Gene Expression Profile;Gene Knock-Out Model;Genes;genetic manipulation;Goals;human disease;Hydrolase;immunoregulation;in vivo;Inflammation;Inflammatory;Injury;Integrins;Ligands;Link;Lipase;lysophosphatidylserine;Macrophage;Macrophage Activation;Maintenance;Mediating;Metabolic;Microglia;Modeling;Molecular;Motor;motor disorder;motor function improvement;mouse model;Mus;Muscle;Mutation;Nerve;Nerve Degeneration;Neurodegenerative Disorders;Neuroglia;neuroinflammation;Neurons;novel;overexpression;Pathologic;Pathology;Pathway interactions;Patients;periostin;Peripheral;peripheral nerve regeneration;Peripheral Nerves;Peripheral Nervous System Diseases;Phagocytes;Phase;Phenotype;phosphatidylserine receptor;Phosphatidylserines;Play;Polyneuropathy;Process;programs;Rare Diseases;receptor;Recovery;recruit;repaired;response;response to injury;Role;Schwann Cells;Shapes;Signal Transduction;Signaling Protein;Spinal Cord;Stress;Symptoms;Tenascin;Testing;Therapeutic;Trauma;Viral

PROJECT_TITLE: The role of SARM1 in neuroinflammation-mediated axonal damage

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


ADMINISTERING_IC: OD

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

ORG_CITY: WASHINGTON

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF THE DISTRICT OF COLUMBIA

ORG_STATE: DC

PHR: Narra�ve for Instrumenta�on Grant The Zeiss AXIO Observer 7 Inverted LED Phase Contrast Fluorescence Microscope will give Faculty and Students at the University of the District of Columbia an opportunity to conduct research using a biomedical tool that can localize or detect in situ, molecules, point measurements and �ssue including changes in these areas that may have major eﬀects on the cell and its surrounding environment. This occurrence plays a major role on public health both locally and na�onally, for the general popula�on in that it is the beginning a pool of diverse health professionals.

PI_NAMEs: COUSIN, CAROLYN EVANS (contact)

PROGRAM_OFFICER_NAME: LI, XIANG-NING

PROJECT_TITLE: The Acquisition of a Zeiss Flourance Phase Contrast Inverted Microscope


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infertility;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: Aurora

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative Given the persistently stark racial/ethnic disparities in perinatal health outcomes in the U.S. and the increasing utilization of fertility treatment to achieve pregnancy, the overall goal of the MOSART EQUITY study is to apply a health equity framework to investigate the experiences and outcomes of minoritized women who receive fertility treatment and achieve a live birth. Utilizing an explanatory sequential mixed-methods study design, we will employ both quantitative and qualitative methodology to investigate the population-level prevalence and factors associated with racial/ethnic disparities in maternal and infant outcomes after fertility treatment among those who have experienced a live birth in Massachusetts.

PI_NAMEs: DIOP, HAFSATOU ;HWANG, SUNAH S (contact)

PROGRAM_OFFICER_NAME: POPKIN, RONNA

PROJECT_TERMS: Accident and Emergency department;Accounting;Address;Asian;Assisted Reproductive Technology;Attitude;Birth;Birth Certificates;Black race;black women;Caring;Centers for Disease Control and Prevention (U.S.);Cesarean section;Child Health;Clinic;Cohort Studies;Communities;community-level factor;Data;Data Sources;Death Records;Development;Discrimination;Equity;ethnic disparity;Ethnic Origin;experience;Female;Fertility;Fertilization in Vitro;Future;Gender;Goals;Grant;health equity;Healthcare;Hispanic;Hispanic Women;hospital readmission;hospital utilization;Hospitalization;indexing;Individual;Infant;Infant Care;Infant Health;infant outcome;Infertility;infertility treatment;Information Systems;Interview;Investigation;Language;Life;Link;Live Birth;Massachusetts;Maternal Health;maternal morbidity;maternal outcome;Methodology;Methods;Minority Women;Monitor;Morbidity - disease rate;mortality;Not Hispanic or Latino;Outcome;Outcome Study;Parents;Peer Review;perinatal health;perinatal period;Persons;Policies;Population;Population Analysis;population based;post pregnancy;Postpartum Period;Pregnancy;Pregnancy Outcome;pregnancy related death;premature;Prevalence;programs;Publications;Publishing;Qualitative Methods;Race;racial disparity;racism;Reporting;Reproductive Sciences;Research;Research Design;Risk;Risk Assessment;Services;social;social determinants;Societies;subfertility;System;Technology;Testing;White Women;Woman;women of color;women's outcomes;Work

PROJECT_TITLE: Massachusetts Outcomes Study of Assisted Reproductive Technology Equity

STUDY_SECTION: HHD

STUDY_SECTION_NAME: Healthcare and Health Disparities Study Section[HHD]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Food Allergies;Health Services;Pediatric

PHR: Project Narrative Eosinophilic Esophagitis is a chronic immune-mediated disorder of the esophagus affecting all ages that has emerged as a common cause of problematic swallowing. Patients with markers of severe disease including stricture/narrowing and esophageal fibrosis have worse symptoms and are more resistant to current treatments. This pilot study aims to compare two available treatments, dupilumab and swallowed fluticasone, in their ability to treat fibrostenotic EoE so as to establish essential data to apply towards pivotal comparative trials with the ensuing goal of informing patients and providers on the comparative benefits and downsides of alternative treatment strategies.

PI_NAMEs: MENARD-KATCHER, CALIES D (contact)

PROGRAM_OFFICER_NAME: UNALP-ARIDA, AYNUR

PROJECT_TERMS: Adaptive Behaviors;Address;Adolescent;Adolescent and Young Adult;adolescent patient;Adult;Affect;Age;Allergens;alternative treatment;Appearance;associated symptom;biobank;Biological Markers;Biological Products;Biological Specimen Banks;Biopsy;Caring;Characteristics;Child;Chronic;Clinical;clinical care;clinical phenotype;Clinical Trials;cohort;comparative;comparative effectiveness;comparative effectiveness trial;Comparative Study;comparative trial;Data;Deglutition;Deglutition Disorders;Disease;disease phenotype;Effectiveness;eosinophil;Eosinophilic Esophagitis;Esophageal Diseases;Esophageal mucous membrane;Esophagus;Feasibility Studies;Fibrosis;fluticasone;Food;Foundations;Goals;Guidelines;health care service utilization;Histologic;human monoclonal antibodies;Immune;improved;Inflammation;Inflammatory;innovation;insight;instrument;Interleukin 4 Receptor;Interleukin-13;Interleukin-4;Intervention;Link;Longitudinal, observational study;Measures;Mediating;meetings;Methods;Mission;Modeling;Mucous Membrane;National Institute of Diabetes and Digestive and Kidney Diseases;novel;Outcome;Outcome Measure;Pathologic;Pathway interactions;patient subsets;Patients;Pharmaceutical Preparations;Phase;Phenotype;Pilot Projects;placebo controlled study;Prevalence;primary endpoint;Provider;Quality of life;Randomized;randomized trial;randomized, clinical trials;recruit;Reporting;repository;Research Design;Resistance;response;Risk;Safety;Sampling;secondary endpoint;Severities;Severity of illness;side effect;Signal Transduction;Stenosis;Surrogate Markers;Symptom Burden;Symptoms;Testing;Therapeutic;Therapeutic Trials;Topical Corticosteroids;treatment response;treatment strategy

PROJECT_TITLE: Comparative study of dupilumab and fluticasone in management of fibrostenotic Eosinophilic Esophagitis; a pilot and feasibility clinical trial.

STUDY_SECTION: DNPD

STUDY_SECTION_NAME: Digestive and Nutrient Physiology and Diseases Study Section [DNPD]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Eye Disease and Disorders of Vision;Genetics;Neurosciences

ORG_CITY: La Jolla

ORG_NAME: SALK INSTITUTE FOR BIOLOGICAL STUDIES

PHR: Project Narrative Understanding the detailed organization of cortical circuits involving specific neuron types is necessary to obtain a mechanistic understanding of the function of the cerebral cortex. Understanding the specific roles of genetically accessed neuron types in cortical function has important implications for human health, as these cell types and their activities are implicated in the cortical mechanisms that regulate attention and their disruption is implicated in schizophrenia and autism.

PI_NAMEs: CALLAWAY, EDWARD M (contact)

PROGRAM_OFFICER_NAME: DAVID, KAREN KATE

PROJECT_TERMS: adeno-associated viral vector;Adopted;Animals;Antibodies;area striata;Attention;autism spectrum disorder;Autopsy;Behavior;Brain;calcium indicator;cell cortex;cell type;Cells;Cerebral cortex;Chloride Channels;Cognition;Communities;Complex;D Cells;design;Disease;Electrodes;Enhancers;Epilepsy;experimental study;Future;Gene Expression;Genes;Genetic Enhancer Element;Health;Histology;Human;imaging approach;in vivo;in vivo imaging;inhibitory neuron;insight;Interneurons;Light;light scattering;Location;Macaca;Maps;Measures;Mediating;Mental Depression;Methods;Monkeys;Mus;Nervous System;Nervous System Disorder;Nervous System Physiology;Neurons;nonhuman primate;Optics;optogenetics;Parvalbumins;Perception;Primates;Property;Proteins;Reagent;red fluorescent protein;response;RNA;Rodent;Role;Schizophrenia;selective expression;sensor;Somatostatin;Stains;Stimulus;Surface;System;Target Populations;Testing;Thick;tool;transgene expression;Transgenes;two-photon;V1 neuron;Virus;Vision;Visual;Visual Cortex;visual stimulus

PROJECT_TITLE: Cross-species conservation of inhibitory cell type contributions to visual cortical function

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 ICN-W (55)]


NIH_SPENDING_CATS: Diabetes;Eye Disease and Disorders of Vision;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: WINSTON-SALEM

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

ORG_STATE: NC

PHR: PROJECT NARRATIVE  Diabetic retinopathy is a common complication of diabetes and the leading cause of blindness in the working age population. Fenofibrate is the first oral drug ever with proven effects on diabetic retinopathy in type 2 diabetic patients by two independent clinical studies. This project will elucidate the mechanism responsible for the therapeutic effect of fenofibrate on diabetic retinopathy and facilitate the FDA approval of this oral drug treatment for diabetic retinopathy.

PI_NAMEs: MA, JIAN-XING  (contact)

PROGRAM_OFFICER_NAME: GORDIYENKO, NATALIYA

PROJECT_TERMS: 3-hydroxy-3-methylglutaryl-coenzyme A;Ablation;Address;Age;Agonist;Animal Model;Astrocytes;Attenuated;Biological Assay;Blindness;Blood capillaries;Blood Vessels;Blood-Retinal Barrier;Carnitine Palmitoyltransferase I;Cell Separation;Cells;cellular targeting;Clinical;Clinical Research;Coculture Techniques;Complications of Diabetes Mellitus;conditional knockout;Coupling;Cytosol;density;Diabetes Mellitus;diabetic;diabetic patient;Diabetic Retinopathy;Down-Regulation;Dyslipidemias;Endothelial Cells;Exclusion;fatty acid oxidation;fatty acid-binding proteins;Fatty Acids;Fenofibrate;Flow Cytometry;Functional disorder;Genes;Genotype;Genus Hippocampus;glial activation;Glycolysis;Grant;Immune;Impairment;In Situ Nick-End Labeling;Inflammation;Inflammatory;intercellular communication;Ketones;Knock-out;Ligands;lipid metabolism;Lipids;Measures;Metabolic;metabolic profile;Metabolism;metabolomics;Microglia;migration;Mitochondria;Mitochondrial DNA;mitochondrial dysfunction;Modeling;Molecular;Morphology;mtTF1 transcription factor;Mus;Neonatal;neurotrophic factor;novel;Nuclear Receptors;Oral;Oral Administration;overexpression;paracrine;Pathogenicity;Pericytes;Permeability;Pharmaceutical Preparations;Pharmacotherapy;Play;Population;PPAR alpha;Production;prospective;Proteins;Proteomics;Regulation;Reporting;Retina;Retinal Degeneration;Role;senescence;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Stains;Stimulator of Interferon Genes;Structure;Therapeutic Effect;Tight Junctions;transcription factor;Transgenic Mice;Transgenic Organisms;Type 2 diabetic;Vascular Permeabilities

PROJECT_TITLE: A new pathogenic mechanism for diabetic retinopathy


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Clinical Research;Heart Disease;Organ Transplantation;Rare Diseases;Transplantation

ORG_CITY: LOS ANGELES

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: R01 – PROJECT NARRATIVE A central objective of this project is to characterize the signal transduction pathways activated by the binding of antibodies to HLAI and HLAII in human primary endothelial cells (ECs) and assess their contribution to the proliferation, migration of these cells and in promoting the recruitment of leukocytes in the context of transplant rejection. The mechanistic studies with ECs will be complemented using a novel mouse model of chronic antibody-mediated rejection (cAMR) and human cardiac allografts with transplant vasculopathy.

PI_NAMEs: FAIRCHILD, ROBERT L;REED, ELAINE F (contact);ROZENGURT, JUAN ENRIQUE

PROGRAM_OFFICER_NAME: KULKARNI, SHILPA S

PROJECT_TERMS: Adherence;Adhesions;Allografting;antagonist;Antibodies;antibody-mediated rejection;Binding;Blood Vessels;Cardiac;Cations;cell injury;cell motility;Cell Proliferation;Cell Survival;Characteristics;Chronic;Clinical;Complex;crosslink;Development;donor-specific antibody;Endothelial Cells;Endothelium;Exhibits;Exocytosis;Exocytosis Induction;Fibrosis;Gene Expression;Genetic;Graft Rejection;Growth;heart allograft;Heart Transplantation;Histocompatibility Antigens Class II;Human;In Vitro;in vivo;Inflammation;Inflammatory;inhibitor;Injury;Integrin beta4;Ion Channel;Knowledge;Lesion;Leukocytes;Ligation;Macrophage;Mediating;Membrane;migration;Molecular;monocyte;mouse model;novel;Organ;organ transplant recipient;Organ Transplantation;Outcome;P-Selectin;Pathogenesis;Pathogenicity;Pattern recognition receptor;Perivascular Fibrosis;pharmacologic;PI3K/AKT;Piezo 1 ion channel;Piezo ion channels;Play;prevent;Process;Proliferating;PTK2 gene;Publishing;receptor;recruit;response;Risk;Role;Signal Pathway;Signal Transduction;Signal Transduction Pathway;Solid;Surface;Testing;Therapeutic;therapeutic target;TLR4 gene;Transducers;Transplantation;Vascular Diseases;Weibel-Palade Bodies

PROJECT_TITLE: The role of HLA and its coreceptors in endothelial cell activation and leukocyte recruitment in antibody-mediated transplant rejection

STUDY_SECTION: TTT

STUDY_SECTION_NAME: Transplantation, Tolerance, and Tumor Immunology Study Section[TTT]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Dental, Oral, and Craniofacial Disease;Genetics;Infectious Diseases

ORG_CITY: Los Angeles

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: PROJECT NARRATIVE Dental caries is a complex infectious disease with multiple genetic and environmental risk factors posing a major health burden globally. The goal of this proposal is to provide insight into the structure, dynamic interactions and multifunctionality of ameloblastin protein, and hence to contribute to the fundamental knowledge as relevant to enamel formation, and to understanding of inherited diseases of enamel and genetic factors that affect caries susceptibility. Insight gained from the proposed studies will contribute to biomimetic efforts to regenerate and reconstruct dental hard tissues.

PI_NAMEs: OLDAK, JANET  (contact)

PROGRAM_OFFICER_NAME: WAN, JASON

PROJECT_TERMS: 3-Dimensional;Adhesions;Affect;ameloblastin;Ameloblasts;Amelogenesis;amelogenin;Apatites;Binding;Biological;Biomimetics;biomineralization;biophysical model;Cell Adhesion;Cell Communication;Cell Culture Techniques;Cell Differentiation process;Cell Line;Cell membrane;Cell model;Cell-Matrix Junction;Cells;Cellular Structures;Chemical Models;Chemicals;Communicable Diseases;Complex;CRISPR/Cas technology;Crystal Formation;Data;Deletion Mutation;Dental;Dental caries;Dental Enamel;Disease;Enamel Formation;Environmental Risk Factor;Exhibits;Exons;Extracellular Matrix;Gene Expression;Genes;Genetic;genetic risk factor;Goals;Growth;Health;Hereditary Disease;In Vitro;in vitro Model;in vivo;in vivo Model;Inherited;insight;Interruption;Investigation;Knowledge;Laboratories;Liposomes;Longevity;Mediating;Membrane;mineralization;Minerals;Modeling;Molecular;Morphology;mouse model;mutant mouse model;Mutant Strains Mice;Natural regeneration;novel;Outcome;Peptides;Phenotype;Play;polarized cell;Predisposition;Process;Property;Proteins;Publishing;Recombinant Proteins;Regulation;Reporting;Role;self assembly;Severities;Structure;Testing;three dimensional cell culture;Tissues;Tooth structure;unilamellar vesicle;Variant

PROJECT_TITLE: MATRIX BASED MINERAL ENAMEL-BIOMIMETICS

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]


NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Neurosciences;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

PHR: PROJECT NARRATIVE The tooth root is essential for the proper function of the dentition because it anchors the tooth within the jaw bone, transmits occlusal forces, and provides a passageway for nerves and vasculature. However, little is known about how tooth root patterning and development are regulated. We have designed studies to uncover the signaling mechanism that regulates the fate of progenitor cells during tooth root development and patterning, which will advance stem cell-mediated tooth root regeneration.

PI_NAMEs: CHAI, YANG  (contact)

PROGRAM_OFFICER_NAME: SAIFUDEEN, ZUBAIDA

PROJECT_TERMS: Anatomy;Animal Model;Atlases;Bite Force;bone;Cell Cycle Progression;Cell Cycle Regulation;Cell Physiology;Cells;Cephalic;Craniofacial Abnormalities;Crowns;Data;Defect;Dental;Dentition;Development;Epigenetic Process;Equilibrium;Esthesia;Face;Fibroblast Growth Factor;Genes;Genetic Transcription;inhibitor;Jaw;Knowledge;Mandible;Mastication;Maxilla;Mechanics;Mediating;Mediator;Mesenchymal Stem Cells;Mesenchyme;Modeling;Molecular;Natural regeneration;Nerve;nerve supply;Neural Crest;Neural Crest Cell;neurovascular;Organogenesis;Pathway interactions;Pattern;Periodontal Ligament;Piezo 1 ion channel;Piezo 2 ion channel;Play;Positioning Attribute;Process;progenitor;Proteins;Regulation;Research Design;Role;sensor;Shapes;Signal Pathway;Signal Transduction;single-cell RNA sequencing;spatiotemporal;Specificity;Speech;stem cell fate;stem cells;Testing;Tooth Crowns;Tooth root structure;Tooth structure;transcription factor;transmission process;Trigeminal nerve structure;Vascular blood supply;WNT Signaling Pathway;Work

PROJECT_TITLE: The Molecular Regulatory Mechanism of Tooth Root Development

STUDY_SECTION: SBDD

STUDY_SECTION_NAME: Skeletal Biology Development and Disease Study Section[SBDD]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: NARRATIVE: In this project, we will investigate how health disparities may affect immunotherapy for breast cancer. The Research Project will use a combination of registry data, clinical trials data, matched gene expression and genotype data and single nuclear analysis to investigate various ways that disparities can affect response to immune checkpoint inhibitors across populations. The Administrative Core will support interactions among the investigators and plan future projects leveraging the results from the research project.

PI_NAMEs: ZIV, ELAD  (contact)

PROGRAM_OFFICER_NAME: WALLACE, TIFFANY A

PROJECT_TERMS: Accreditation;adaptive immune response;Address;advanced breast cancer;Adverse event;Affect;African ancestry;African Women;Age;Area;Asian;Asian Women;Automobile Driving;Biological Markers;Black race;black women;Breast Cancer Patient;California;cancer health disparity;cancer type;cell type;Clinical;Clinical Trials;comorbidity;Data;Data Analyses;data registry;Data Set;Diagnosis;Disease;Disparity;drug action;environmental stressor;epidemiologic data;Estrogen Receptors;ethnic difference;Ethnic Origin;Ethnic Population;Future;Gene Expression;Gene Expression Profile;Gene Frequency;Genetic;genetic variant;Genotype;Geography;Germ Lines;health disparity;high risk;Hispanic;Immune;Immune checkpoint inhibitor;Immune response;Immunooncology;immunoreaction;Immunotherapy;improved;In complete remission;Individual;Infiltration;Insurance;Interferons;Investigation;Latina;Lymphocytic Infiltrate;Macrophage;Malignant Breast Neoplasm;Mammary Neoplasms;Marital Status;Mediator;mortality risk;Neighborhoods;neoplasm registry;neoplastic cell;Not Hispanic or Latino;Nuclear;Nuclear RNA;organizational structure;Outcome;Pathologic;Pathway interactions;Patient Selection;Patient Self-Report;Patients;PD-1 inhibitors;pembrolizumab;phase III trial;Population;Population Analysis;population based;Progesterone Receptors;Prognosis;Prognostic Factor;Race;racial difference;racial population;Recurrence;Research Personnel;Research Project Grants;responders and non-responders;response;social;social determinants;social factors;social stressor;Stratification;T-Lymphocyte;Testing;The Cancer Genome Atlas;transcriptome sequencing;treatment response;triple-negative invasive breast carcinoma;tumor;tumor immunology;tumor-immune system interactions;White Women;Woman;women's outcomes;Women's trial

PROJECT_TITLE: Race and ancestry as predictors of the tumor immune microenvironment and response to immunotherapy

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-F (J1)]


NIH_SPENDING_CATS: Behavioral and Social Science;Breast Cancer;Cancer;Cancer Genomics;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Immunotherapy;Precision Medicine;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

PROJECT_TERMS: Accreditation;adaptive immune response;Address;advanced breast cancer;Adverse event;Affect;African ancestry;African Women;Age;Area;Asian;Asian Women;Automobile Driving;Biological Markers;Black race;black women;Breast Cancer Patient;California;cancer health disparity;cancer type;cell type;Clinical;comorbidity;Data;Data Analyses;Data Set;Diagnosis;Disease;Disparity;drug action;environmental stressor;epidemiologic data;Estrogen Receptors;ethnic difference;Ethnic Origin;Ethnic Population;Gene Expression;Gene Expression Profile;Gene Frequency;Genetic;genetic variant;Genotype;Geography;Germ Lines;health disparity;high risk;Hispanic;Immune;Immune checkpoint inhibitor;Immune response;Immunooncology;immunoreaction;Immunotherapy;improved;In complete remission;Individual;Infiltration;Insurance;Interferons;Investigation;Latina;Lymphocytic Infiltrate;Macrophage;Malignant Breast Neoplasm;Mammary Neoplasms;Marital Status;Mediator;mortality risk;Neighborhoods;neoplasm registry;neoplastic cell;Not Hispanic or Latino;Nuclear RNA;organizational structure;Outcome;Pathologic;Pathway interactions;Patient Selection;Patient Self-Report;Patients;PD-1 inhibitors;pembrolizumab;phase III trial;Population;Population Analysis;population based;Progesterone Receptors;Prognosis;Prognostic Factor;Race;racial difference;racial population;Recurrence;Research Project Grants;responders and non-responders;response;social;social determinants;social factors;social stressor;Stratification;T-Lymphocyte;Testing;The Cancer Genome Atlas;transcriptome sequencing;treatment response;triple-negative invasive breast carcinoma;tumor;tumor immunology;tumor-immune system interactions;White Women;Woman;women's outcomes;Women's trial

PROJECT_TITLE: Admin Core


NIH_SPENDING_CATS: Behavioral and Social Science;Breast Cancer;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Immunotherapy;Precision Medicine;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

PROJECT_TITLE: Project-Race and ancestry as predictors of the tumor immune microenvironment and response to immunotherapy


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Liver Disease;Nutrition;Pediatric

PHR: PROJECT NARRATIVE This application conducts basic and translational research aimed at the identification of therapeutic strategies to reduce intestinal failure-associated liver disease (IFALD) that occurs after resection of long stretches of bowel, which may arise in children, for example, that present with necrotizing enterocolitis after birth. Specifically, we will evaluate whether intestinal epithelial activation of the transcription factor LXRα may provide therapeutic benefit toward treating IFALD and, if so, we aim to identify its mechanism of action.

PI_NAMEs: ELGENDY, BAHAA ;JAIN, AJAY K.;RANDOLPH, GWENDALYN J (contact);WARNER, BRAD WAYNE

PROGRAM_OFFICER_NAME: GREENWEL, PATRICIA

PROJECT_TERMS: Address;Agonist;ATP binding cassette transporter 1;Basic Science;Binding;Biogenesis;Birth;Blood;Cells;Child;Childhood;Clinical;clinical development;Complication;Data;design;Disease;Dose;Drug Kinetics;Enteral Nutrition;Enterocytes;Evidence based treatment;Excision;Failure;Fibrosis;Funding;Gene Expression;Genes;Genetic Models;Grant;Growth;Hepatic;high density lipoprotein receptor;High Density Lipoproteins;Human;ileum;Image;infancy;intestinal epithelium;Intestinal Secretions;Intestines;Kupffer Cells;Length;Lipids;Liver;Liver diseases;Liver Failure;Liver Fibrosis;liver injury;Liver X Receptor;LXRalpha protein;microbiome;Modeling;mortality;mouse model;Mus;Necrotizing Enterocolitis;novel;Nutrient;nutrient absorption;Operative Surgical Procedures;Oral;Parenteral Nutrition;particle;Patients;Pharmaceutical Preparations;polypeptide;porcine model;Portal vein structure;Principal Investigator;Production;Protein Isoforms;Proteins;Recycling;response;Role;Short Bowel Syndrome;Signal Transduction;Small Intestines;Stretching;Therapeutic;therapy design;TLR4 gene;transcription factor;Transcriptional Activation;translational potential;Translational Research;Work

PROJECT_TITLE: Intestinally restricted LXR agonism in ameliorating liver failure in short gut syndrome

STUDY_SECTION: NMHD

STUDY_SECTION_NAME: Nutrition and Metabolism in Health and Disease Study Section[NMHD]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Mental Health;Neurodegenerative;Neurosciences;Nutrition

ORG_CITY: NOVATO

ORG_NAME: BUCK INSTITUTE FOR RESEARCH ON AGING

PHR: PROJECT NARRATIVE Delirium is a devasting acute confusional state that is common in older adults after surgery or in the hospital, especially with Alzheimer’s disease. This project investigates the molecular mechanisms that link inflammation to impaired metabolism in delirium and Alzheimer’s disease, and how small molecule metabolites with roles in aging might lead to metabolic therapies for delirium.

PI_NAMEs: NEWMAN, JOHN C (contact)

PROGRAM_OFFICER_NAME: ROBERTS, LUCI

PROJECT_TERMS: Acute;Affect;Age;Aging;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease related dementia;analog;APP-PS1;Area;Attention;Basic Science;Behavior;Behavioral;beta-Hydroxybutyrate;Biological Markers;Biology;Biology of Aging;Brain;Cells;Cerebrospinal Fluid;Cerebrum;Chronic;Clinical;clinical development;Clinical Research;Cognitive deficits;cohort;Cohort Studies;Compensation;Confusion;Conscious;Consumption;Cultured Cells;Data;Delirium;Dementia;Development;disability;drug discovery;Elderly;Encephalitis;Energy Metabolism;Energy-Generating Resources;Enzyme Induction;Enzymes;Failure;Fasting;Functional disorder;Genetic Models;Geroscience;glial activation;Glucose;glucose metabolism;Goals;high risk;Hospitalization;Hospitals;Human;Hypoxia;Impairment;improved;In Vitro;in vitro Model;in vivo;Induced Neurons;Infection;Inflammasome;Inflammation;Inflammatory;Injections;innovation;Intervention;ketogenic diet;Ketone Bodies;Ketones;Knock-out;Knockout Mice;Link;Lipopolysaccharides;Macrophage;Macrophage Activation;Mediator;Memory;Metabolic;Metabolic dysfunction;Metabolism;Microglia;Modeling;Molecular;mortality risk;mouse model;Mus;NAD+ Nucleosidase;neuroinflammation;Neuronal Dysfunction;Neurons;Nicotinamide adenine dinucleotide;older adult;Operative Surgical Procedures;Oxidative Stress;Pathway interactions;Patients;Peripheral;Persons;Pharmaceutical Preparations;Pharmacological Treatment;Phenotype;physiologic stressor;postoperative delirium;Postoperative Period;Predisposition;prevent;Prevention;resilience;Risk;Role;Sampling;sedative;Signal Transduction;small molecule;Surgical complication;Syndrome;System;Testing;theories;Work

PROJECT_TITLE: Geroscience metabolites beta-hydroxybutyrate and NAD+ linking inflammation and neuroenergetic failure in delirium


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Health Services;Neurodegenerative;Neurosciences;Patient Safety;Prevention

ORG_CITY: PALO ALTO

ORG_NAME: PALO ALTO VETERANS INSTIT FOR RESEARCH

PHR: PROJECT NARRATIVE The risk to benefit ratio of cardiovascular medications can change as people age and develop chronic conditions like Alzheimer's disease and related dementias. Nursing home admission, expected in over half of U.S. adults, is commonly accompanied by medication changes. This research will evaluate the frequency and outcomes of cardiovascular medication changes among people with and without dementia who enter nursing homes.

PI_NAMEs: ODDEN, MICHELLE CHRISTINA (contact)

PROGRAM_OFFICER_NAME: SALIVE, MARCEL

PROJECT_TERMS: acute coronary syndrome;Address;Admission activity;Adult;Adverse event;adverse event risk;Age;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease related dementia;Anti-Hypertensive Agents;Anticoagulants;Aspirin;Atrial Fibrillation;Bar Codes;Blood Platelets;cardioprotection;Cardiovascular Diseases;Cardiovascular system;career;Caring;Characteristics;Chronic;Clinical;Clinical Trials;Cognitive;cohort;coronary event;Data;decision-making capacity;Dementia;Descriptive Epidemiology;Dose;Epidemiology;Event;Frequencies;functional outcomes;Glucose;Goals;Grant;Hemorrhage;high risk;human old age (65+);Impaired cognition;Impairment;Incidence;Inpatients;Laboratories;Link;Long-Term Care;Measurement;Medicare/Medicaid;medication administration;Medication Management;Mentors;Methods;mortality;Myocardial Infarction;novel;Nursing Homes;Observation in research;Outcome;Outpatients;Paper;Patients;Persons;Pharmaceutical Preparations;Physical Function;Population;Preventive;Primary Prevention;Process;Provider;Publications;Randomized, Controlled Trials;Recording of previous events;Regimen;Research;Risk;Science;Scientist;Secondary Prevention;statistics;Stroke;Structure;success;symposium;Uncertainty;Veterans Health Administration;Work

PROJECT_TITLE: Deprescribing Cardiovascular Medications among Persons with and without Alzheimer's Disease and Related Dementias in Long-Term Care

STUDY_SECTION: ASG

STUDY_SECTION_NAME: Aging Systems and Geriatrics Study Section[ASG]


NIH_SPENDING_CATS: Cancer;Genetics;Human Genome

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Narrative My research program is devoted to understanding fundamental mechanisms of genome integrity control and how they impact cancer etiology and response to therapy. We will continue to approach these central questions in cancer biology by utilizing unique systems that we have developed to investigate the molecular basis underlying (1) DNA damage recognition, (2) genomic lesions that activate classical and alternative forms of homology directed DNA repair, and (3) response to targeted agents. These pursuits will provide invaluable insights into cancers that arise as a consequence of altered usage of DNA repair pathways, and their adaptive responses to DNA damaging therapies.

PI_NAMEs: GREENBERG, ROGER A (contact)

PROGRAM_OFFICER_NAME: WITKIN, KEREN L

PROJECT_TERMS: adduct;Affect;ATP phosphohydrolase;ATRX gene;base;Binding;Biochemical;BRCA mutations;BRCA1 gene;BRCA2 gene;Bypass;Cancer Biology;Cancer Etiology;cancer genome;cell type;Cells;Chromatin;chromatin modification;Complement;DNA biosynthesis;DNA Damage;DNA lesion;DNA Repair;DNA Repair Pathway;Elements;Enzymes;Event;Excision;Exonuclease;Funding;Genetic Predisposition to Disease;Genetic Recombination;genome integrity;Genome Stability;Genomics;Goals;helicase;homologous recombination;homologous recombination deficiency;Human;Hypersensitivity;Immunoglobulin Switch Recombination;In Vitro;insight;Lesion;Malignant Neoplasms;Molecular;mutant;Mutate;Mutation Analysis;Nucleosomes;Okazaki fragments;Outcome;Pathway interactions;Poly(ADP-ribose) Polymerase Inhibitor;Polymerase;Process;programs;Proteins;reconstitution;recruit;repaired;Reporting;Research;response;Role;S phase;Single Strand Break Repair;Single-Stranded DNA;Slide;Structure;System;targeted agent;telomere;telomere damage;Telomere Maintenance;Telomere Recombination;Testing;treatment response

PROJECT_TITLE: Roles of Chromatin Modification in BRCA1 Dependent DNA Repair

STUDY_SECTION: MG

STUDY_SECTION_NAME: Molecular Genetics Study Section[MG]


ADMINISTERING_IC: OH

FUNDING_MECHANISM: OTHERS

IC_NAME: NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH

ORG_CITY: BATON ROUGE

ORG_NAME: LOUISIANA STATE OFFICE OF PUBLIC HEALTH

ORG_STATE: LA

PHR: PAR-20-312: State Occupational Health and Safety Surveillance Louisiana Occupational Health and Injury Surveillance Program Project Narrative Work-related injuries and illnesses in Louisiana have significant economic and human consequences. The proposed occupational health surveillance programs aim to track the extent of work-related injuries, illnesses, and fatalities in Louisiana, and to develop and disseminate prevention strategies to reduce their impact.

PI_NAMEs: REILLY, ANNA DUNNE (contact)

PROGRAM_OFFICER_NAME: O'NEILL, EDUARDO

PROJECT_TITLE: Occupational Health and Injury Surveillance in Louisiana


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

ORG_CITY: BIRMINGHAM

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Program Director/Principal Investigator (Last, First, Middle): Lungu, Claudiu T. Narrative: The Deep South Center for Occupational Health and Safety (DSC) was established in 1982 as an Education and Research Center with the participation of two major Universities, University of Alabama at Birmingham (UAB) and Auburn University (AU). The mission of the DSC is to Train and develop professionals who protect and promote the health and safety of workers through interdisciplinary education, training, research and outreach. Recognizing the OSH burden that affects disproportionally racial and ethnic minority groups as well as disadvantaged communities and individuals, the DSC will focus on minimizing this burden while striving to eliminate disparities showing our commitment to DEI. OMB No. 0925-0001/0002 (Rev. 03/2020 Approved Through 02/28/2023) Page Continuation Format Page

PI_NAMEs: LUNGU, CLAUDIU T (contact)

PROJECT_TITLE: Deep South Occupational Safety and Health Education and Research Center


ADMINISTERING_IC: TS

IC_NAME: AGENCY FOR TOXIC SUBSTANCES AND DISEASE REGISTRY

ORG_CITY: BOSTON

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

PHR: Project Narrative We will take advantage of a new extremely large linked Department of Defense and Veterans Administration database to examine the association between military experience and both incidence of and survival with amyotrophic lateral sclerosis (ALS). We will also assess how use of statins relates to ALS incidence and survival and whether their use protects against adverse effects of any military exposures.

PI_NAMEs: WEISSKOPF, MARC G (contact)

PROJECT_TITLE: Military exposures and ALS in a large veteran population


ORG_CITY: COLLEGE STATION

ORG_NAME: TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR

ORG_STATE: TX

PHR: PROJECT NARRATIVE Occupational safety and health specialists are critical to ensuring the safety and health of the nation’s worksites and workforce. This program addresses the shortage of qualified occupational safety and health professionals by delivering a high-quality program and successful graduates who meet the ever-growing industry demand. Program faculty integrate emerging issues related to workplace health and safety in the training of future OHS leaders.

PI_NAMEs: BENDEN, MARK EDWARD (contact)

PROJECT_TITLE: Texas A&M University Health Science Center Occupational Safety and Health Training Program


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Infectious Diseases;Microbiome

ORG_CITY: HOUSTON

ORG_NAME: METHODIST HOSPITAL RESEARCH INSTITUTE

PHR: PUBLIC HEALTH RELEVANCE Antimicrobial resistance (AMR) is a top public-health priority. Training the next generation of clinician scientists and translational scholars is critical to tackle the dire consequences of AMR. After building a successful patient-oriented and translational program on AMR with a major training component, I plan to leverage these resources to expand my training, research and leadership capabilities in AMR, contributing to solve this major public health crisis.

PI_NAMEs: ARIAS, CESAR AUGUSTO (contact)

PROGRAM_OFFICER_NAME: HUNTLEY, CLAYTON C

PROJECT_TERMS: academic standard;anti-microbial peptide;Antibiotic Resistance;Antimicrobial Resistance;Area;Award;Bacteremia;base;Basic Science;Biological;career;career development;Cefazolin;Cell membrane;Cessation of life;Clinical;clinical epidemiology;clinical practice;Clinical Sciences;clinically relevant;Collaborations;commensal microbes;Communicable Diseases;Complex;Country;Critical Illness;Dedications;Development;Diagnostic;Doctor of Pharmacy;Doctor of Philosophy;Enterococcus;Evolution;feasibility testing;Fortification;Fostering;Foundations;Funding;Future;Generations;genomic epidemiology;Genomics;Goals;Grant;gulf coast;host microbiota;Immunocompromised Host;Infection;infection management;Infrastructure;insight;Institution;inter-institutional;Lead;Leadership;Machine Learning;Medical center;Mentors;Mentorship;Metagenomics;microbial genomics;microbiome research;microbiota;Mid-Career Clinical Scientist Award (K24);Midcareer Investigator Award in Patient-Oriented Research;Mission;Molecular;Molecular Epidemiology;multi-drug resistant pathogen;Multiple Bacterial Drug Resistance;Names;next generation;novel;novel therapeutic intervention;Organism;Outcome;pathogen;patient oriented;patient oriented research;Patients;Phenotype;Physicians;Population;Positioning Attribute;Postdoctoral Fellow;Predisposition;Program Research Project Grants;programs;Public Health;public health priorities;public health relevance;Publications;rapid test;recruit;Research;Research Personnel;Resistance;Resources;response;Scientist;Secure;Sepsis;skills;Structure;System;Talents;Testing;Texas;Therapeutic;tool;Training;Training Programs;Translational Research;translational study;Translations;United Nations;United States National Institutes of Health;Vancomycin resistant enterococcus;Vision

PROJECT_TITLE: POR and Training Program on Multidrug-Resistant Organisms

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases B Research Study Section[MID-B]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Mental Health;Neurosciences

ORG_DEPT: PSYCHIATRY

PHR: PROJECT NARRATIVE Social attachments form the basis of human relationships at every level of social organization, and disruptions in attachment occur across the spectrum of mental illness, with severe neuropsychiatric disorders often manifesting with a dramatic collapse of social attachment and cognition. While pioneering work identified the peptide hormones vasopressin (Avp) and oxytocin (Oxt) as critical mediators of pair bonding in socially monogamous prairie voles, and of social cognition and behaviors in humans, until now, we have been unable to understand how the receptors for Oxt (OxtR) and Avp (V1aR) facilitate long term social attachments. We propose to investigate how these receptors control social attachment behaviors, and neuronal activity and gene expression in regions of the brain that mediate social attachment, providing neural and molecular insights that, eventually, will inform new therapeutic approaches across the spectrum of mental illness.

PI_NAMEs: MANOLI, DEVANAND SADANAND (contact)

PROGRAM_OFFICER_NAME: BREEDEN, ANDREW LEE

PROJECT_TERMS: Adult;Aggressive behavior;Amygdaloid structure;Animals;Behavior;Behavioral;Behavioral Assay;Brain;Brain region;Child;Child Rearing;Clinical Trials;Comparative Study;Complex;CRISPR/Cas technology;Fiber;Gene Expression;Gene Expression Profiling;gene function;Genetic;genetic analysis;Germ Lines;Group Affiliation;Heterozygote;Hormone use;Human;in vivo;insight;Lateral;Medial;Mediating;Mediator;Memory;Mental disorders;Microtus;model organism;Molecular;Molecular Profiling;mouse genetics;mutant;Mutation;neural;neural patterning;Neurons;neuropsychiatric disorder;neuropsychiatry;neuroregulation;novel;novel therapeutic intervention;Nucleus Accumbens;object recognition;Optics;Other Genetics;Oxytocin;Oxytocin Receptor;Pair Bond;Parents;Partner in relationship;Pathway interactions;Pattern;peer;peptide hormone;Photometry;Population;prairie vole;preference;receptor;receptor function;response;Rodent;Role;sex;Siblings;Signal Transduction;social;social attachment;Social Behavior;social cognition;Social Controls;Social Interaction;social organization;species difference;System;Territoriality;Testing;Transcript;transcriptome sequencing;Vasopressins;Work

PROJECT_TITLE: Understanding the neural basis of social attachment

STUDY_SECTION: NNRS

STUDY_SECTION_NAME: Neuroendocrinology, Neuroimmunology, Rhythms and Sleep Study Section[NNRS]


NIH_SPENDING_CATS: Biotechnology;HIV/AIDS;Infectious Diseases;Prevention;Sexually Transmitted Infections;Women's Health Research

ORG_CITY: CHICAGO

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: RELEVANCE (See instructions): Developing interventions to prevent HIV infections requires a more complete understanding of how transmission is initiated and progresses to cause systemic infection. The studies proposed here will leverage state-of-the-art methodologies that can identify foci of viral replication that can be defined and characterized to guide optimization of HIV prevention approaches.

PI_NAMEs: HOPE, THOMAS  (contact)

PROGRAM_OFFICER_NAME: CUMMINS, JAMES E

PROJECT_TERMS: 3-Dimensional;Address;Adjuvant;Agonist;AIDS prevention;Anatomy;Animals;Antibodies;Antigens;Area;Autopsy;Award;Black Box;CD4 Positive T Lymphocytes;cell motility;cell type;Cells;Colon;Complex;Core Facility;Coupled;cytokine;Descending colon;design;draining lymph node;empowerment;env Gene Products;Environment;Event;experience;Eye;Goals;Goblet Cells;HIV;HIV Infections;HIV vaccine;Homeostasis;Image;imaging approach;Immune response;Infection;Inflammatory;Inflammatory Response;Injectable;Injections;innovation;insight;Instruction;Integration Host Factors;interest;Interferons;Intervention;Knowledge;Label;Left;Light;Luciferases;Lymph;Lymphocyte;Macrophage;Mesentery;Metabolic;meter;Methodology;Methods;Microscopy;Monkeys;Mucous Membrane;Myelogenous;Myeloid Cells;nanometer;Natural History;nef Protein;neutralizing antibody;new technology;next generation;novel;novel strategies;particle;Pathway interactions;PET/CT scan;Phase;Phenotype;Physiology;Point Mutation;Population Heterogeneity;Predisposition;prevent;Prevention approach;Prevention strategy;preventive intervention;Principal Investigator;Process;programs;Progress Reports;rapid detection;rectal transmission;Rectum;Reporter;Resolution;response;Science;sexual HIV transmission;Signal Transduction;Site;SIV;Structure;success;Surveys;System;Systemic infection;T-Lymphocyte;Techniques;Testing;Tissues;Transmission Electron Microscopy;transmission process;Tropism;Vagina;vaginal transmission;vector;Viral;Viremia;Virus;Virus Replication

PROJECT_TITLE: Identification of the Initial Targets of Transmission

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: BRONX

ORG_NAME: JAMES J PETERS VA  MEDICAL CENTER

ORG_STATE: NY

PHR: Home health aides (HHAs) are a vital lifeline for older Veterans, improving health outcomes for Veterans and caregivers and delaying or avoiding costly institutional care. This CDA addresses urgent VA and legislative priorities to improve Veterans’ access to and retention of stable HHA care by systematically identifying pathways to receiving and maintaining VA HHA benefits, and adapting and testing an evidence-based VA family caregiver support curriculum (Caregivers FIRST) to fill HHAs’ skills gaps and improve retention. My findings will generate systematic knowledge of how Veterans navigate benefit roadblocks and identify and test potential points of intervention. My extensive research and professional experience with HHAs and my qualitative training prepare me for this work. With mentorship and training in process improvement, intervention development, implementation science, and trial design, I will turn my CDA’s findings into actionable, effective, and scalable interventions that leverage existing VA resources to support high-quality HHA care.

PI_NAMEs: FRANZOSA, EMILY C. (contact)

PROJECT_TERMS: Address;Advisory Committees;Affect;Aging;aging in place;Area;Bathing;career;Caregiver Burden;caregiver strain;Caregiver support;Caregivers;caregiving;Caring;Case Management;Communities;community based service;Complex;Contracts;coping;cost;Data;design;disability;Eating;Educational Curriculum;effectiveness evaluation;Effectiveness of Interventions;Emotional;Ensure;evidence base;Evidence based intervention;experience;Family Caregiver;formative assessment;Future;Geography;Goals;Health;Health system;Home;home based service;Home Health Agency;Home Health Aides;Homogeneously Staining Region;Household;Hybrids;implementation evaluation;implementation outcomes;implementation science;Improve Access;improved;Individual;innovation;Institution;Intervention;Knowledge;Light;Loneliness;Long-Term Care;Maps;Measures;Mental Depression;Mentors;Mentorship;Methodology;Methods;mortality;Outcome;Pathway interactions;Policies;prevent;Primary Care;primary care team;Process;process improvement;Provider;Quality of life;Readiness;Research;Research Personnel;research study;Resources;Services;Site;skills;social;Standardization;Structure;System;Testing;theories;therapy design;therapy development;Training;Training Programs;trial design;Variant;Veterans;Work

PROJECT_TITLE: Maximizing the Value of VA Homemaker/Home Health Aide (H/HHA) Services to Veterans, Caregivers and VA: Supporting Older Veterans’ Pathways to Stable H/HHA Care

STUDY_SECTION_NAME: Research Career Scientist[MRA0]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: ANN ARBOR

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: The Neural Engineering Training Program (NETP) will train a new generation of scientists with both hard engineering skills and a solid understanding of the underlying biology. Trainees of this program will create the next generation of bioelectronic implants, in collaboration with clinicians, basic scientists, and industry. By exposing students to clinical practice, NETP trainees will be well prepared to solve the challenges facing neurotechnology and bioelectronics.

PI_NAMEs: WEILAND, JAMES D. (contact)

PROGRAM_OFFICER_NAME: WEIGAND, LETITIA ALEXIS

PROJECT_TERMS: Engineering;neural;Training Programs


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

ORG_CITY: PITTSBURGH

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative Hearing and balance disorders affect a large percentage of our population. About 30-35 percent of adults between the ages of 65 and 75 years have a hearing loss, and it is estimated that about 50 million US citizens experience tinnitus in their lifetime. Balance disorders are also prevalent in the population, particularly amongst the elderly. More than one in three people age 65 years or older fall each year, and falls are the leading cause of hospitalization amongst the elderly. The proposed program will train the next generation of scientists to provide cures for hearing and balance disorders.

PI_NAMEs: KANDLER, KARL  (contact);YATES, BILL J

PROGRAM_OFFICER_NAME: RIVERA-RENTAS, ALBERTO L

PROJECT_TITLE: Training in Auditory and Vestibular Neuroscience


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_CITY: COLLEGE PARK

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

ORG_STATE: MD

PHR: Narrative The phenomenon of plasticity that is the focus of the proposed research is fundamental to learning, behavioral performance, and to the repair of the nervous system after damage. Our goal is to understand how plasticity manifests itself in the responses of the auditory cortex, and how do the acoustic stimuli interact with the behavioral feedback to influence the changes in the cortex. The findings of this research could have profound consequences for the design and deployment of hearing aids and cochlear implants.

PI_NAMEs: SHAMMA, SHIHAB A (contact)

PROGRAM_OFFICER_NAME: MILLER, ROGER

PROJECT_TITLE: Spectro-Temporal Plasticity in Primary Auditory Cortex

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


NIH_SPENDING_CATS: Neurosciences;Regenerative Medicine

PHR: PROJECT NARRATIVE We propose a cross-disciplinary training program that brings together regeneration biologists, neurophysiologists, and clinician researchers to form mentorship teams within the largest medical research center in the world: The Texas Medical Center. This training program will foster a new generation of scientists who will in turn help build a new frontier of biology: neural control of organ degeneration and regeneration.

PI_NAMEs: HORNER, PHILIP J (contact)

PROJECT_TITLE: Training in Neural Control of organ Degeneration and Regeneration (NeuralCODR)


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Substance Misuse

PHR: Excessive alcohol consumption is third among the causes of preventable death in the United States. To reduce this heavy toll on the health of the nation, the next generation of alcohol researchers needs to be trained in the most current and sophisticated scientific methods to understand and to reduce alcohol abuse, dependence, and alcohol-related mortality. This proposal is to train these individuals in an ongoing program that has a history of successfully training researchers in alcohol research.

PI_NAMEs: MOLINA, BROOKE S.G. (contact)

PROGRAM_OFFICER_NAME: FREEMAN, ROBERT

PROJECT_TITLE: Developmental Alcohol Research Training Grant


NIH_SPENDING_CATS: Cancer;Dental, Oral, and Craniofacial Disease;Lymphatic Research;Rare Diseases

ORG_CITY: Nashville

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: This project will study the mechanism and impact of exosome secretion in head and neck squamous cell carcinoma progression. The project is relevant to public health because it will lead to a greater understanding of mechanisms that lead to head and neck cancer aggressiveness and identify molecular correlates of latent metastasis.

PI_NAMEs: WEAVER, ALISSA M (contact)

PROGRAM_OFFICER_NAME: WOODHOUSE, ELIZABETH

PROJECT_TERMS: Actins;angiogenesis;autocrine;Behavior;Biological Markers;Blood;Body Fluids;cancer cell;cell motility;Cells;Clinical;combinatorial;Complement;Data;Defect;Development;Distant Metastasis;Docking;EMS1 gene;Endosomes;Ephrin B Receptor;Ephrin-B2;Ephrins;exosome;extracellular vesicles;Family;Flow Cytometry;Gene Amplification;genetic regulatory protein;Head and Neck Cancer;Head and Neck Squamous Cell Carcinoma;Human;Immunofluorescence Immunologic;in vivo;intercellular communication;interest;Invaded;Ligands;Lipids;liquid biopsy;lymph nodes;Lymphangiogenesis;Malignant Neoplasms;member;Metastatic Neoplasm to Lymph Nodes;Methods;migration;Modeling;Molecular;Neck Dissection;Neoplasm Metastasis;novel;Nucleic Acids;Oncogenic;overexpression;paracrine;Pathologic;Pathological Staging;patient prognosis;Patients;Plasma;Play;Prognosis;Proteins;Proteomics;Public Health;radiological imaging;Recurrence;Recurrent tumor;Role;Signal Transduction;Signaling Protein;Site;Stains;Structure;synergism;Testing;Tissue Microarray;Tissue Sample;Tissue Stains;Tissues;tumor;Tumor Angiogenesis;tumor growth;tumor microenvironment;tumor progression;Tumor Promotion;Tumor-Derived;Work

PROJECT_TITLE: Exosomes in HNSCC Progression

STUDY_SECTION: TPM

STUDY_SECTION_NAME: Tumor Progression and Metastasis Study Section[TPM]


NIH_SPENDING_CATS: Mental Health;Neurosciences

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY

PHR: This project will train researchers in critical areas of research relevant to mental health. The program will support advances in knowledge that will improve the mental health outcomes for those suffering from developmental disabilities and mental disorders, and will advance the research priorities of the NIMH.

PI_NAMEs: KIORPES, LYNNE  (contact)

PROGRAM_OFFICER_NAME: VAN'T VEER, ASHLEE VICTORIA

PROJECT_TERMS: Neurosciences;System;Training

PROJECT_TITLE: Training Systems and Integrative Neuroscience


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Aging;Atherosclerosis;Cardiovascular;Clinical Research;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Human Genome;Precision Medicine;Prevention

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

ORG_STATE: MA

PHR: PROJECT NARRATIVE / PUBLIC HEALTH RELEVANCE Genetic analyses of lipids have yielded important clinical and therapeutic insights for cardiovascular disease, the persistent leading cause of death worldwide. We now propose genetic analyses in millions of diverse individuals to prioritize new therapeutic targets for lipids and cardiovascular disease, and characterize the diverse clinical consequences of putative targets toward pleiotropic cardiometabolic prevention. We further aim to use our results to identify individuals who are at highest risk of cardiovascular disease earlier in life with the goal of prevention by analyzing genetic data in completed clinical trials.

PI_NAMEs: NATARAJAN, PRADEEP ;PELOSO, GINA MARIE (contact)

PROGRAM_OFFICER_NAME: JAQUISH, CASHELL E

PROJECT_TERMS: Address;Adult;Age;Alleles;Atherosclerosis;Award;biobank;Biological;Biology;blood lipid;candidate identification;Cardiometabolic Disease;cardiometabolism;Cardiovascular Diagnostic Techniques;Cardiovascular Diseases;cardiovascular disorder risk;Cardiovascular system;causal variant;Cause of Death;Cholesterol;Clinical;clinical practice;Clinical Trials;cohort;Collaborations;Computing Methodologies;Coronary heart disease;Coupled;Data;Development;Disease;epidemiology study;Ethics;Familial Hypercholesterolemia;Fatty Liver;Foundations;gene discovery;Genes;Genetic;genetic analysis;genetic association;genetic predictors;Genetic Risk;Genetic study;genetic variant;Genetic Variation;genome wide association study;genomic locus;Genomics;Genotype;Goals;Guidelines;heart disease risk;Heart Diseases;Heritability;High Density Lipoprotein Cholesterol;High Density Lipoproteins;high risk;Human Genetics;improved;Individual;innovation;insight;International;Intervention;Knowledge;LDL Cholesterol Lipoproteins;Leadership;Life;Lipids;lipoprotein cholesterol;low and middle-income countries;Maps;Measures;Medicine;Mendelian randomization;Meta-Analysis;Methodology;Methods;middle age;Modality;Modeling;multi-ethnic;multidisciplinary;new therapeutic target;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutics;older adult;Online Systems;Pancreatitis;Pathway interactions;phenome;Phenotype;Plasma;polygenic risk score;Positioning Attribute;precision medicine;predictive marker;predictive modeling;prevent;Prevention;Prevention strategy;Preventive care;Preventive therapy;Productivity;public health relevance;Publishing;Randomized, Controlled Trials;Recommendation;Recording of previous events;Research;Risk;Risk Factors;risk mitigation;Risk Reduction;risk variant;Sampling;Scanning;Secure;sex;Standardization;Statistical Methods;statistics;success;Therapeutic;therapeutic development;therapeutic target;tool;Triglycerides;Variant;Veterans;Work;young adult

PROJECT_TITLE: Using genetic variation to study biology of blood lipids & coronary heart disease

STUDY_SECTION: CHSA

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology A Study Section[CHSA]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Genetic Testing;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Rural Health

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: PROJECT NARRATIVE Germline genetic testing can change a cancer patient’s treatment and how their family members are cared for, yet many patients are not able to access testing and patients, who live in rural communities, have lower literacy and who do not speak English are especially impacted. We will develop and evaluate whether a multilingual animated computer character, called a relational agent (RA), can be used to provide genetic education to help overcome these barriers at two clinical centers (including a low-resource safety-net hospital). We expect that our work will have a significant clinical impact, both increasing access to timely genetic testing for cancer patients, in cancer and more widely across disease domains.

PI_NAMEs: BICKMORE, TIMOTHY W.;BRAUN, DANIELLE ;RICKER, CHARITE NICOLETTE (contact)

PROGRAM_OFFICER_NAME: CAGA-ANAN, EMILIE CHARLISSE F

PROJECT_TERMS: Academic Medical Centers;access disparities;Address;advanced disease;Advanced Malignant Neoplasm;Age;animation;Area;arm;Behavior;California;cancer care;cancer diagnosis;cancer genetics;cancer initiation;Cancer Patient;cancer risk;cancer type;care outcomes;Caring;chatbot;Clinic;Clinical;clinical center;Clinical Practice Guideline;cohort;Communication;Computers;contextual factors;Counseling;County;Disease;Disparity;Early Diagnosis;Education;Ensure;Epithelial ovarian cancer;Face;Family;Family history of;Family member;Focus Groups;Foundations;Future;Genetic;Genetic Counseling;Genetic Services;genetic testing;Genomics;Germ Lines;Goals;Guidelines;Health education;Health Personnel;Healthcare;Hospitals;implementation barriers;implementation context;improved;Individual;Information Technology;Inherited;innovation;Internet;Interview;Knowledge;Language;Limited English Proficiency;Linguistics;literacy;Los Angeles;Low Literacy Population;Malignant neoplasm of male breast;Malignant neoplasm of pancreas;Malignant neoplasm of prostate;Malignant Neoplasms;Measures;Medical center;Modeling;Multilingualism;neoplasm resource;non-verbal;novel;Oncology;Operative Surgical Procedures;Ovarian;Pancreas;Participant;Patient Care;patient population;patient subsets;Patients;pilot test;Population;Predisposition;Prevention;primary outcome;Prostate;Provider;randomized trial;Randomized, Controlled Trials;Readiness;Recommendation;Recording of previous events;recruit;Relative Risks;Research;Resources;Rural Community;Rural Population;rural setting;safety net;satisfaction;secondary outcome;shared decision making;Site;Spanish;Spanish/English;targeted treatment;Technology;Test Result;Testing;testing access;tool;treatment as usual;trial comparing;Universities;University Hospitals;Update;uptake;usability;verbal;Work

PROJECT_TITLE: Increasing Access to Genetic Testing in Underserved Patients Using a Multilingual Conversational Agent


NIH_SPENDING_CATS: Bioengineering;Cancer;Cervical Cancer;Clinical Research;HIV/AIDS;Health Services;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Primary Health Care;Sexually Transmitted Infections;Women's Health Research

ORG_DEPT: NEUROLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative We propose to investigate the accuracy and implementation potential of a new technology that provides an automated and almost instant classification of cervical cancer precursor lesions based on a cloud-based, machine-learning algorithm of an image of the cervix. We will investigate the clinical utility of this new technology for integrating into screen-and-treat programs for women living with and without HIV in South Africa.

PI_NAMEs: KUHN, LOUISE  (contact)

PROGRAM_OFFICER_NAME: VILLALOBOS, AUBREY VAN KIRK

PROJECT_TERMS: Acceleration;Acetic Acids;Address;Algorithms;antiretroviral therapy;automated visual evaluation;Automobile Driving;Biological Assay;Biopsy;Cellular Phone;Cervical;Cervical Cancer Screening;Cervical Intraepithelial Neoplasia;Cervix Uteri;Characteristics;Classification;Clinical;clinical research site;cloud based;Collaborations;Colposcopes;Colposcopy;cost;cost effective;cost effectiveness;Cytology;Data;Development;Diagnosis;digital;digital imaging;DNA;Effectiveness;effectiveness study;FDA approved;General Population;Generations;Goals;Health Services;High Prevalence;high risk population;Histologic;histological specimens;HIV;HPV positive;HPV screening;Human papilloma virus infection;Human Papilloma Virus Vaccine;Human Papillomavirus;Image;Imaging technology;implementation evaluation;improved;Incidence;India;Infrastructure;Investigation;Lesion;Licensing;low and middle-income countries;machine learning algorithm;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Marketing;Methods;Modeling;Morbidity - disease rate;mortality;new technology;Output;Performance;point of care;Predictive Value;Price;Primary Prevention;Procedures;programs;Provider;Qualifying;randomized, clinical trials;Recommendation;recruit;Reporting;Resources;Risk;Safety;screening;screening program;screening services;Secondary Prevention;Services;South Africa;South African;Specificity;success;Testing;Time;Triage;Universities;Visit;Visual;Woman;Women's Group;Women's prevalence;Work;World Health Organization

PROJECT_TITLE: Automated Digital Imaging for Cervical Cancer Screening

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Health Services;Palliative Care;Social Determinants of Health

ORG_DEPT: OTHER HEALTH PROFESSIONS

PHR: PROJECT NARRATIVE A priority focus in oncology and palliative care is preparing the 3.2 million U.S. family caregivers of persons with cancer to effectively partner with patients in health-related decision-making from diagnosis to the end of life, particularly in underserved settings. Over 70% of patients with cancer involve relatives, friends, and partners in healthcare decisions, including choices about cancer treatments, surgery, transitions and location of care, accessing palliative and hospice care, and many others. Patients making healthcare decisions with unprepared family caregivers may experience inadequate family decision support leading to heightened distress and receipt of care/treatments inconsistent with their values and preferences, which may in turn increase distress for family caregivers.

PI_NAMEs: ODOM, JAMES N. (contact)

PROGRAM_OFFICER_NAME: MOLLICA, MICHELLE A

PROJECT_TERMS: 2 arm randomized control trial;Address;Adult;advanced directive;Advanced Malignant Neoplasm;Anxiety;Appointment;Cancer Family;Cancer Patient;cancer therapy;caregiver interventions;Caregiver support;Caregivers;caregiving;Caring;Clinical;Communication;Comprehensive Cancer Center;Conflict (Psychology);Consumption;cost;cost effective;Decision Making;Diagnosis;Distress;Effectiveness;end of life;experience;Family;Family Caregiver;Friends;Health;health care service utilization;Healthcare;Hospice Care;Hospitals;improved;innovation;Interdisciplinary Study;Intervention;Location;Malignant Neoplasms;Measures;Mediator;Mental Depression;Methodology;multiphase optimization strategy;NCI-Designated Cancer Center;Newly Diagnosed;novel;Oncology;Operative Surgical Procedures;Outcome;Palliative Care;Patients;Persons;pilot test;preference;primary outcome;Process;Professional Practice;psychoeducation;Quality of life;Randomized;recruit;Reporting;Reproducibility;Research;Research Design;Research Methodology;response;secondary outcome;Self Efficacy;skills;Social support;sociodemographics;telehealth;Testing;theories;therapy design;Time;Training;Training Support;Underrepresented Populations

PROJECT_TITLE: Decision Support Training for Advanced Cancer Family Caregivers: The CASCADE Factorial Trial

STUDY_SECTION: CMGC

STUDY_SECTION_NAME: Clinical Management in General Care Settings Study Section[CMGC]


NIH_SPENDING_CATS: Infectious Diseases;Malaria;Rare Diseases;Vector-Borne Diseases

ORG_CITY: SEATTLE

ORG_NAME: INSTITUTE FOR SYSTEMS BIOLOGY

ORG_STATE: WA

PHR: PROJECT NARRATIVE _____ Malaria remains one of the great global health problems today, with nearly half a million deaths and millions of new infections occurring annually. This research will determine how the malaria parasite specially modifies a small number of its most important proteins in order to enhance their function. Understanding these modifications will help to improve the design of vaccines that target these proteins in order to arrest parasite development and prevent disease.

PI_NAMEs: SWEARINGEN, KRISTIAN EDWARD (contact)

PROGRAM_OFFICER_NAME: MCGUGAN, GLEN C

PROJECT_TERMS: Adhesives;Amino Acid Substitution;Anti-malarials;Binding;Catalogs;cell motility;Cell surface;Cell-Matrix Junction;Cells;Cessation of life;Chordata;Culicidae;Data;Defect;Development;Disease;Extracellular Matrix;fitness;Fucose;Fucosyltransferase;global health;glycosylation;glycosyltransferase;Goals;heparin proteoglycan;Human;improved;In Vitro;in vivo;Individual;Infection;insight;interest;Intervention;Invaded;Life Cycle Stages;Link;Malaria;Mannose;Mannosyltransferases;Mass Spectrum Analysis;Membrane Proteins;Methods;Modification;Mutation;Nematoda;Oocysts;parasite invasion;Parasites;Plasmodium;Plasmodium falciparum;Plasmodium vivax;Play;Polysaccharides;prevent;protein function;Protein Glycosylation;Proteins;Proteoglycan;Recombinant Proteins;Recombinants;Research;Rodent;Role;Serine;Site;Sporozoites;System;Tertiary Protein Structure;Testing;Threonine;Thrombospondins;Time;Transgenic Organisms;Tryptophan;Vaccine Design;Virulence;Virulence Factors;Work

PROJECT_TITLE: Elucidating the role of TSR glycosylation in Plasmodium parasites

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDM-M(02)]


ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: Project Narrative The Integrative Vascular Biology Program was established in 2002 to provide the next generation of scientists with the interdisciplinary and collaborative skills necessary to uncover the mechanisms by which genetic variation and environmental factors influence cardiovascular development and disease. Centered around UNC's McAllister Heart Institute, our 42 well-established, well-funded, and highly diverse faculty will provide state-of- the-art research training as part of a Program that requires trainees to collaborate with secondary mentors outside of their major area of interest. When combined with a well-developed academic program in Cardiovascular Science, well-developed research infrastructure at UNC, and a large pool of well-qualified applicants, our Program offers an outstanding environment for multidisciplinary pre-doctoral training.

PI_NAMEs: MACK, CHRISTOPHER P. (contact)

PROGRAM_OFFICER_NAME: LIDMAN, KARIN FREDRIKSSON

PROJECT_TITLE: Pre-doctoral Training Program in Integrative Vascular Biology

STUDY_SECTION: NITM

STUDY_SECTION_NAME: NHLBI Institutional Training Mechanism Study Section[NITM(JA)]


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Clinical Research;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases

ORG_CITY: BALTIMORE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PHR: NARRATIVE The Integrated Networks of Scholars in Global Health Research Training (INSIGHT) consortium formed between the University of Alabama at Birmingham, the Baylor College of Medicine, the University of Maryland Baltimore, and the University of Pittsburgh supports training for the next generation of global health scholars from the US and low- and middle-income countries (LMICs) through mentored research experiences at 24 established partner LMIC institutions across 19 countries in Africa, Asia, and Latin America and the Caribbean. Strong emphases are on a broad range of global health research areas, including combatting the global HIV epidemic and associated co-morbidities, emerging and re-emerging infectious diseases, non-communicable diseases, and mental health.

PI_NAMEs: CHARURAT, MANHATTAN E (contact);MANDALAKAS, ANNA M;NIMGAONKAR, VISHWAJIT LAXMIKANT;TURAN, JANET M.

PROGRAM_OFFICER_NAME: HAYES, UNJA

PROJECT_TERMS: Africa South of the Sahara;Applications Grants;Area;Asia;Behavioral;career;Caribbean region;Clinical;cohort;Collaborations;Disease;Emerging Communicable Diseases;Ensure;Environment;Epidemic;equity, diversity, and inclusion;Faculty;Foundations;Generations;global health;HIV;innovation;Institution;interdisciplinary collaboration;Laboratories;Latin America;Leadership;Link;low and middle-income countries;member;Mental Health;Mentors;Mentorship;Minority-Serving Institution;Monitor;multidisciplinary;Outcome;outreach;Postdoctoral Fellow;pre-doctoral;Process;Program Evaluation;programs;Publishing;Research;Research Personnel;Research Training;Role;Schools;Science;Shapes;Strategic Planning;student participation;Training;Training Programs;Underrepresented Minority;Underrepresented Populations;Universities;Vision;Woman;Work


NIH_SPENDING_CATS: Atherosclerosis;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_CITY: MILWAUKEE

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: Sphingolipids can promote or prevent microvascular endothelial dysfunction, which precedes large artery atherosclerosis. We hypothesize that formation of ceramide, although detrimental following chronic exposure, is necessary for proper microvascular function. The results of this study could greatly expand our understanding of local tissue perfusion and provide novel targets for the treatment of cardiovascular disease.

PI_NAMEs: FREED, JULIE K (contact)

PROGRAM_OFFICER_NAME: GAO, YUNLING

PROJECT_TERMS: acute stress;Address;Adipose tissue;Antiinflammatory Effect;Arteries;arteriole;Atherosclerosis;Blood Vessels;Cardiac;Cardiovascular Diseases;caveolin 1;Ceramides;Chronic;Coronary;Coronary Arteriosclerosis;Data;Development;Dilator;Disease;EFRAC;endothelial dysfunction;Endothelium;Event;Exposure to;Fatty acid glycerol esters;Generations;Goals;Health;Heart failure;Human;Hydrogen Peroxide;in vivo;Individual;inflammatory milieu;Knowledge;Mediating;Mediator;Metabolism;Microcirculation;Microvascular Dysfunction;Mitochondria;NADPH Oxidase;new therapeutic target;Nitric Oxide;NOS3 gene;novel;novel strategies;Pathogenicity;Pathologic;Pathway interactions;Patients;Perfusion;Peripheral;Phenotype;Plasma;Play;preservation;pressure;prevent;Production;Research;response;Risk;Risk Factors;Role;shear stress;Signal Transduction;Sphingolipids;sphingosine 1-phosphate;Sphingosine-1-Phosphate Receptor;Stress;targeted treatment;theories;Therapeutic Intervention;Tissues;translational approach;translational study;vascular endothelial dysfunction;Vascular Endothelium;volunteer

PROJECT_TITLE: Dual Functionality of Ceramide in Human Microvascular Endothelial Function

STUDY_SECTION: IVPP

STUDY_SECTION_NAME: Integrative Vascular Physiology and Pathology Study Section[IVPP]


NIH_SPENDING_CATS: Cancer;Hematology;Obesity;Rare Diseases

ORG_CITY: PORTLAND

ORG_NAME: MAINEHEALTH

ORG_STATE: ME

PHR: The overall goal of this application is to change how multiple myeloma, an incurable blood cancer, is understood and treated. We will discover new forms of cancer drug resistance that are driven by fat cell- derived factors. Thus, we will expose new interventions to overcome drug resistance to improve survival and quality of life for myeloma patients and patients with other cancers that grow in the bone.

PI_NAMEs: REAGAN, MICHAELA R. (contact)

PROGRAM_OFFICER_NAME: FORRY, SUZANNE L

PROJECT_TERMS: 3-Dimensional;Address;Adipocytes;adipokines;Adipose tissue;Adult;Affect;Aging;autocrine;Automobile Driving;B-Cell Neoplasm;Biological;bone;Bone Diseases;Bone Marrow;Bone Marrow Cells;cancer cell;cancer drug resistance;Cancer Model;Cell Culture Techniques;Cell Proliferation;Cell Survival;Cells;Clinical;Coculture Techniques;Compensation;Data;Development;dietary;Dimensions;Disease Progression;Disease Resistance;drug development;Drug resistance;drug resistance development;Energy Metabolism;Energy-Generating Resources;Environment;Exhibits;experience;Exposure to;FABP4 gene;FABP5 gene;Fatty acid glycerol esters;fatty acid-binding proteins;Fatty Acids;Feedback;Feeds;Fracture;Gene Expression;Generations;Genes;Genetic;Genetic Models;Goals;Growth;Hematopoietic Neoplasms;high body mass index;High Fat Diet;Homing;Human;Human body;IL6 gene;improved;In Vitro;in vivo;in vivo Model;Individual;Inflammatory;instrument;Intervention;Laboratory Finding;lipid metabolism;Lipids;Malignant - descriptor;Malignant Neoplasms;MAP Kinase Gene;Mediator;Messenger RNA;Modeling;mouse model;Multiple Myeloma;Mus;Mutation;Nature;neoplastic cell;new therapeutic target;Nonesterified Fatty Acids;novel;novel therapeutics;Obesity;Older Population;Osteolysis;Osteoporosis;paracrine;Pathway interactions;Patients;Pattern;pharmacologic;Pharmacotherapy;Phenotype;physiologic model;PI3K/AKT;PIK3CG gene;Plasma Cells;PPARG gene;prevent;Process;Proliferating;protein expression;Proteins;Quality of life;Research;resistance mechanism;Resources;response;Risk;Risk Factors;Role;scaffold;Signal Induction;Signal Transduction;Silk;Soil;Source;survival outcome;Symptoms;targeted treatment;Testing;Therapeutic;therapy resistant;Tissue Engineering;Tissue Model;tumor;tumor growth;two-dimensional;uptake

PROJECT_TITLE: Defining the Roles of Bone Marrow Adipocytes and FABP4/5 Signaling in Multiple Myeloma Drug Resistance

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 1 Study Section[MCT1]


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

PHR: NARRATIVE The CTSA K12 Program at UNC is a three-year training program for faculty research Scholars that has a goal of training the next generation of translational scientists in how to design, conduct and disseminate research that benefits all individuals and promotes health equity. The Scholars conduct a research project and obtain training focused on research methods, professional skills, mentoring, well-being and leadership of inclusive teams.

PI_NAMEs: HERNANDEZ, MICHELLE  (contact);JULIANO, JONATHAN J

PROGRAM_OFFICER_NAME: BOUGH, KRISTOPHER J

PROJECT_TERMS: Acceleration;Active Learning;Address;career;career development;Characteristics;Clinic;cohort;Collaborations;Communities;Companions;Dedications;Discipline;Disease;empowerment;Equity;equity, diversity, and inclusion;experience;Faculty;Fostering;Genes;Grant;Health;health disparity;health equity;health equity promotion;Health Policy;Infrastructure;K-Series Research Career Programs;Language;Lead;Leadership;lens;Mentored Clinical Scientist Development Program;Mentors;Methods;Modeling;North Carolina;peer;Personal Satisfaction;Productivity;Program Development;programs;recruit;Research;research and development;resilience;Science;Scientific Advances and Accomplishments;Scientist;Services;skill acquisition;skills;Support System;System;Time;Training;Translational Research;translational scientist;Translations;Underrepresented Populations;Universities

PROJECT_TITLE: CTSA K12 Program at UNC


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Digestive Diseases;Genetics;Human Genome;Liver Cancer;Liver Disease;Rare Diseases

ORG_CITY: SAN ANTONIO

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

PHR: The objective of our research is to find potential molecular mechanisms that contribute to increased incidence of hepatocellular carcinoma (HCC) in the US with approaches involving the use of novel HCC cell lines and mouse models. Our proposed research may uncover novel molecular pathways driving liver carcinogenesis and potential targets for the development of novel preventive and therapeutic strategies.

PI_NAMEs: SUN, LUZHE  (contact)

PROGRAM_OFFICER_NAME: COUCH, JENNIFER A

PROJECT_TERMS: Acceleration;adduct;Affect;Agar;Automobile Driving;Binding;Binding Sites;Biochemical;Biological Assay;Biological Process;Biophysics;C-terminal;Cancer Cell Growth;Cancer Etiology;cell growth;cell motility;Cells;Cessation of life;Code;Copper;cuprous ion;Data Set;Development;Diet;differential expression;DNA;DNA Damage;Elements;Engineering;Family;Family member;Flavins;Genes;Goals;Growth;Heme;Hemochromatosis;Hepatic;Hepatocarcinogenesis;hepatocellular carcinoma cell line;Hepatolenticular Degeneration;Homeostasis;Human;Hydrogen Peroxide;Hydroxyl Radical;In Vitro;in vivo;Incidence;Intake;Ions;Iron;Iron Overload;knock-down;Lipid Peroxidation;Liver;liver cancer model;Malignant - descriptor;Malignant Epithelial Cell;Malignant Neoplasms;MAPK8 gene;Mediating;Membrane;Metals;Mitogen-Activated Protein Kinases;Molecular;Motility;mouse model;Mutation;N-terminal;NADP;NADPH Oxidase;neoplastic cell;novel;Oncogenic;Organelles;Organoids;overexpression;Oxidation-Reduction;Oxidative Stress;Oxidoreductase;p38 Mitogen Activated Protein Kinase;Pathway interactions;Patients;Preventive;Primary carcinoma of the liver cells;Production;Property;Protein Family;Proteins;Publishing;Research;Reverse Transcriptase Polymerase Chain Reaction;Risk Factors;RNA;Role;Sampling;Site;six transmembrane epithelial antigen of the prostate 2;Stains;Stress;Testing;The Cancer Genome Atlas;Therapeutic;Time;Tissues;transcriptome sequencing;tumor;Tumor Promotion;Tumor Tissue;tumorigenesis;tumorigenic;Up-Regulation;Validation;Western Blotting;whole genome;Xenograft procedure

PROJECT_TITLE: Role of STEAP2 protein in hepatocarcinogenesis


NIH_SPENDING_CATS: Neurosciences;Sleep Research

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Sleep and circadian rhythm disorders, which are highly prevalent and have a major impact on physical and behavioral health, safety, quality of life and longevity, disrupt the lives of an estimated 50-70 million Americans. At the core of the strategic goals laid out in the 2021 NIH Sleep Research Plan is the recognition of the critical need to foster a strong and diverse workforce required to accelerate fundamental scientific discoveries and translate these to clinical practice and population health to advance public health and safety, transform health care and advance well-being for our nation’s diverse population. Our NHLBI-supported Training Program in Sleep, Circadian and Respiratory Neurobiology directly addresses this need by training a diverse generation of investigators, many of whom are already successfully tackling critical questions in biomedical research aimed to understand the pathophysiology, prevention and treatment of sleep and circadian disorders.

PI_NAMEs: CZEISLER, CHARLES A (contact)

PROGRAM_OFFICER_NAME: BAIZER, LAWRENCE

PROJECT_TITLE: Training in Sleep, Circadian, and Respiratory Neurobiology

STUDY_SECTION_NAME: NHLBI Institutional Training Mechanism Study Section[NITM(OA)]


NIH_SPENDING_CATS: Lung

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Project Narrative Lung disease is a leading cause of death and disability in the United States. Despite an expanding understanding of the causes of lung disease, treatments that cure these disorders are lacking and most treatments are symptomatic or supportive. The goal of this program is to train highly qualified individuals in the research disciplines that are necessary to find better treatment and prevention of these disorders.

PI_NAMEs: HANSEL, NADIA N;SHIMODA, LARISSA A. (contact)

PROGRAM_OFFICER_NAME: KALANTARI, ROYA

PROJECT_TITLE: Multidisciplinary Training Program in Lung Disease