NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Cardiovascular;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Human Genome;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: PROJECT NARRATIVE We propose to conduct a longitudinal epigenomic study of SDH in relation to cardiovascular diseases (CVD) in a large bi-racial cohort, the CARDIA cohort. Our investigation of epigenomic biomarkers associated with long- term exposure to both individual- and neighborhood-level social determinants of health in combination with genomic data and longitudinal CVD risk factors and subclinical and clinical CVD measures will provide important information for the development of a robust CVD prediction algorithm, and enhance our ability to identify at-risk individuals and molecular targets for CVD prevention and to lessen CVD disparity.

PI_NAMEs: HOU, LIFANG  (contact);LIU, LEI ;ZHANG, KAI

PROGRAM_OFFICER_NAME: FU, YI-PING

PROJECT_TERMS: Address;Adult;Affect;Age;Biological;Biological Markers;biracial;Black race;Cardiovascular Diseases;cardiovascular disorder prevention;cardiovascular disorder risk;cardiovascular health;cardiovascular risk factor;Cardiovascular system;Cause of Death;Censuses;Characteristics;Childhood;Cities;Clinical;clinical development;cohort;Communities;Computer software;coronary artery calcification;Coronary Artery Risk Development in Young Adults Study;cost;cost effective;Cost of Illness;Crime;Cross-Sectional Studies;Data;Development;dimensional analysis;Disease;disease disparity;Disease Outcome;Disparity;DNA;DNA Methylation;Economic Factors;Education;Elderly;Enrollment;Environmental Risk Factor;epigenetic aging;epigenetic marker;Epigenetic Process;epigenomics;ethnic minority population;Exposure to;Funding;Gene Expression;Genetic;genome sequencing;genomic data;Health;Health care facility;health disparity;Health Personnel;high dimensionality;High Prevalence;indexing;Individual;Intervention;Investigation;Knowledge;late life;Life;Life Cycle Stages;life span;Link;longitudinal database;Longitudinal Studies;Measures;Mediating;Mediation;Mediator;member;Methods;Methylation;methylation biomarker;middle age;modifiable risk;Modification;Molecular Target;National Heart, Lung, and Blood Institute;Nature;Neighborhoods;novel;older adult;Outcome;Participant;Patient Self-Report;Physical activity;Physicians;Play;Population;Poverty;prediction algorithm;Process;Quantitative Trait Loci;Race;racial disparity;racial minority population;Research Personnel;Resources;Risk;Risk Factors;Role;Sampling;social;social disparities;social factors;social health determinants;social vulnerability;Socioeconomic Status;Testing;Time;Trans-Omics for Precision Medicine;user-friendly;Variant;Visualization;web app;web interface;whole genome

PROJECT_TITLE: Epigenomic landscape of individual- and neighborhood-level social disadvantages and cardiovascular health disparity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-G(55)]


ADMINISTERING_IC: AI

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Orphan Drug;Patient Safety;Prevention;Rare Diseases;Vector-Borne Diseases;West Nile Virus

ORG_CITY: FORT COLLINS

ORG_COUNTRY: UNITED STATES

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_FIPS: US

ORG_NAME: COLORADO STATE UNIVERSITY

ORG_STATE: CO

PHR: Project Narrative This project is designed to develop endectocide-treated birdfeed as a novel, safe and scientifically-validated way to control the risk of West Nile virus transmission to humans.

PI_NAMEs: FOY, BRIAN DAVID (contact)

PROGRAM_OFFICER_NAME: COSTERO-SAINT DENIS, ADRIANA

PROJECT_TERMS: absorption;Adverse effects;Animals;Anthelmintics;arboviral disease;Arboviruses;Area;Biological Assay;Birds;Bite;Blinded;Blood;California;Cessation of life;Chickens;Colorado;Columbidae;Columbiformes;Communities;comparison control;Conduct Clinical Trials;cost;Culex (Genus);Culicidae;design;Development;Disease;Dose;Drug Kinetics;Eating;Environment;enzootic;Epidemic;epidemiological model;Excipients;experimental study;feeding;field study;Flavivirus;Formulation;Future;Galliformes;Goals;Home;Human;Incidence;indexing;Individual;Ingestion;Insecticides;Intervention;Ivermectin;Marketing;Methods;Modeling;mosquito-borne;mosquitocidal;Neighborhoods;North America;novel;Passeriformes;Persons;Pharmaceutical Preparations;preference;prevent;primary outcome;Probability;Property;Randomized;Randomized, Controlled Trials;Risk;risk minimization;Safety;safety testing;Site;Sparrows;suburban communities;success;System;Technology;Testing;tool;Toxic effect;transmission process;Treatment Efficacy;treatment site;United States;Urban Community;Vaccines;vector;vector control;vector mosquito;viral transmission;Virus Diseases;West Nile virus;wild bird;Work

PROJECT_TITLE: West Nile virus control through mosquitocidal avian bloodmeals

STUDY_SECTION: VB

STUDY_SECTION_NAME: Vector Biology Study Section[VB]


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Digestive Diseases;Genetics;Inflammatory Bowel Disease

ORG_CITY: ANN ARBOR

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE Inflammatory Bowel Disease (IBD) is a chronic and debilitating inflammatory disease of the gastrointestinal tract in urgent need of new therapeutic approaches. The project proposed in this application will reveal an important role for the epithelial-expressed tight junction protein Claudin-23 in the regulation of intestinal barrier function during homeostasis and inflammation. Successful completion of the proposed studies will identify new targets for the treatment of inflammation in IBD and will be pivotal to my development as an independent scientist with interdisciplinary training in cell biology and physiology.

PI_NAMEs: LOZADA-SOTO, KRISTEN MICHELLE (contact)

PROGRAM_OFFICER_NAME: DENSMORE, CHRISTINE L

PROJECT_TERMS: Actins;Active Sites;Adherent Culture;Antigens;Apical;base;Binding Sites;Biochemical;Biological Assay;Biopsy;career;Cell Line;Cell membrane;Cell Physiology;Cells;Cellular biology;chromatin immunoprecipitation;Chronic;Colon;colonic crypt;Complex;Cytoplasm;Cytoskeleton;Data;Development;differential expression;Digestive System Disorders;Disease;disease mechanisms study;DNA Binding;Down-Regulation;Economic Burden;Environmental Risk Factor;Epithelial Cells;Epithelium;Etiology;Event;Family;Family member;fluorescein isothiocyanate dextran;Functional disorder;Gastrointestinal Diseases;gastrointestinal symptom;Genetic Predisposition to Disease;Genetic Transcription;Goals;gut homeostasis;Health;Healthcare Systems;HIF1A gene;Homeostasis;Human;Hypoxia;Hypoxia Inducible Factor;Immune;in silico;In Vitro;in vivo;Inflammation;Inflammatory;Inflammatory Bowel Diseases;Integral Membrane Protein;Intercellular Junctions;intestinal barrier;intestinal crypt;intestinal epithelium;Intestines;Investigation;knock-down;Knock-out;Knockout Mice;Knowledge;Lateral;Link;member;Membrane;Messenger RNA;Modeling;Molecular;monolayer;mRNA Expression;Mucous Membrane;murine colitis;Mus;normoxia;novel;novel therapeutic intervention;Nutrient;Oral;overexpression;Pathologic;Patients;Permeability;Physicians;Physiological;Positioning Attribute;promoter;Property;protein expression;Proteins;Quality of life;Reagent;Regulation;Role;Scaffolding Protein;Scientist;seal;Signal Transduction;Spatial Distribution;Specificity;Stimulus;Techniques;Therapeutic Intervention;Tight Junctions;Tissues;tool;Training;transcription factor;uptake;villin

PROJECT_TITLE: Deciphering the role of Claudin-23 in regulation of the intestinal epithelial barrier


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Genetics;Human Genome;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: PROJECT NARRATIVE Medulloblastoma is the most common malignant brain tumor in children. While patients have tumor histology with a primitive embryonal phenotype with poor prognosis, some medulloblastomas show foci of spontaneous maturation with a brain-like phenotype with improved survival. The objective of this proposal is to dissect the mechanism of medulloblastoma tumor cell maturation and identify targets to induce maturation therapeutically.

PI_NAMEs: RAJU, PRAVEEN B.;SNUDERL, MATIJA  (contact)

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: Adult;Affect;Animal Model;Area;Attentional deficit;Benign;Biology;Blood - brain barrier anatomy;Brain;Brain Neoplasms;brain tissue;Cell Maturation;Central Nervous System;chemotherapy;Child;Childhood Brain Neoplasm;Classification;Clinic;Clinical;cognitive disability;Complex;Deposition;Development;Diagnosis;differential expression;Dissection;DNA Sequence Alteration;Drug Delivery Systems;efficacy evaluation;Endocrine;Epigenetic Process;epigenetic regulation;epigenomics;exome sequencing;EZH2 gene;Functional disorder;gain of function;gene repression;Genes;Genetic;Genetic Transcription;genome-wide analysis;Genomics;Goals;Growth;Histology;Histone H3;Human;human disease;human tissue;improved;Infertility;inhibitor;International;Learning Disabilities;Leptomeninges;Lesion;loss of function;Malignant - descriptor;Malignant neoplasm of brain;Malignant Neoplasms;Medulloblastoma;Memory;Meta-Analysis;Methylation;Modeling;Molecular;Molecular Profiling;Morbidity - disease rate;mouse model;Mus;nanoparticle drug;neoplastic cell;neural;neuroblast;Neuronal Differentiation;Neuropil;novel;novel therapeutics;Pathologist;Pathway interactions;Patient-Focused Outcomes;Patients;Pattern;Pediatric Neoplasm;Pediatric Oncology Group;Penetration;Phenotype;Polycomb;preclinical study;primary endpoint;Process;Prognosis;Proliferating;prospective;Proteins;Radiation therapy;Recurrence;Regimen;Reporting;Resolution;Role;Second Primary Cancers;SHH gene;side effect;Signal Pathway;Sonic Hedgehog Pathway;standard of care;Subgroup;Survival Rate;Survivors;synergism;targeted treatment;Techniques;Testing;Therapeutic;therapy outcome;therapy resistant;Thyroid Gland;Time;Tissue Sample;Tissues;Toxic effect;transcriptome;transcriptome sequencing;transcriptomics;treatment strategy;tumor;Tumor Biology;tumor heterogeneity;Undifferentiated

PROJECT_TITLE: Inducing Neural Maturation in Medulloblastoma by Targeting EZH2

STUDY_SECTION: CAMP

STUDY_SECTION_NAME: Cancer Molecular Pathobiology Study Section[CAMP]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Drug Abuse (NIDA only);Eye Disease and Disorders of Vision;Neurosciences;Substance Misuse

ORG_NAME: COLUMBIA UNIV NEW YORK MORNINGSIDE

PI_NAMEs: WITTEN, ILANA  (contact)

PROJECT_TERMS: Affect;Animals;Authorization documentation;Behavior;Behavioral;Brain;brain cell;Brain region;cell type;Cells;cholinergic;Code;Communication;Computer Models;Computing Methodologies;Contralateral;Corpus striatum structure;Data Analyses;data sharing;Decision Making;Dependence;Environment;experimental study;Goals;Infrastructure;interest;International;Ipsilateral;Laboratories;Left;Linear Models;markov model;Measurement;Mediating;Methods;Midbrain structure;Modeling;Mus;neural;neural circuit;neural correlate;neuromechanism;Neurons;optogenetics;Pathway interactions;Population;response;Role;Sensory;Standardization;Statistical Models;Structure;superior colliculus Corpora quadrigemina;System;Task Performances;Testing;Training;ultrasound;Ventral Striatum;Visual Cortex

PROJECT_TITLE: Causal brainwide interactions underlying internal states and decisions


ADMINISTERING_IC: CA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: KANSAS CITY

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: OVERALL: PROJECT NARRATIVE The University of Kansas Cancer Center (KUCC) aims to leverage unique regional scientific assets to build a nationally significant cancer research center that will become a leading institution for transforming discoveries in the laboratory into new therapeutic approaches. KUCC will expand its depth, breadth and impact and strive to become an NCI-designated comprehensive cancer center that meets the needs of the more than 4.5M Americans who live within the 92,000 square miles of the KUCC catchment area.

PI_NAMEs: JENSEN, ROY A. (contact)

PROGRAM_OFFICER_NAME: SHAFIK, HASNAA

PROJECT_TERMS: Achievement;Advocacy;Advocate;Agreement;American;anti-cancer research;anti-cancer therapeutic;Basic Science;Behavior Therapy;Biometry;Breast;Cancer Biology;Cancer Burden;Cancer Center;Cancer Center Support Grant;Cancer Control;cancer prevention;cancer stem cell;cancer therapy;Caring;Catchment Area;Child;Cities;Clinic;Clinical;clinical care;Clinical Pharmacology;Clinical Research;Clinical Trials;Collaborations;Communities;Comprehensive Cancer Center;Development;Diagnosis;drug development;drug discovery;early phase clinical trial;early phase trial;Education;Ensure;Environment;experience;FDA approved;fighting;Flow Cytometry;Fostering;Funding;Gene Targeting;Goals;Grant;health equity;Health Personnel;Heme;Image;improved;Incidence;Informatics;innovation;Institution;interdisciplinary collaboration;International;Intervention;Investigational New Drug Application;Investigational Therapies;investigator-initiated trial;Kansas;Knowledge;Laboratories;Lead;Leadership;Malignant Neoplasms;Medical center;Medical Research;member;Microscopy;Morbidity - disease rate;morphogens;mortality;multidisciplinary;NCI Center for Cancer Research;NCI-Designated Cancer Center;next generation;novel therapeutic intervention;novel therapeutics;nutrition;Oncology;Outcome;outreach;Patients;Pediatric Oncology;Persons;Physicians;population health;Positioning Attribute;precision medicine;Prevention;programs;Publications;Quality of life;recruit;Research;Research Infrastructure;Research Personnel;Resource Sharing;rural setting;Science;Scientist;stem cell biology;Surveys;survivorship;Technology;Therapeutic;Therapeutic Agents;therapeutic development;tobacco control;Training;Training and Education;Transgenic Organisms;Underserved Population;Universities;urban setting;Vision

PROJECT_TITLE: The University of Kansas Cancer Center

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

ORG_CITY: LA JOLLA

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

ORG_STATE: CA

PHR: This proposal will provide new understanding of the progenitor cell function in homeostatic and diseased LGs. Our study will provide new information how lacrimal gland epithelial and progenitor cells sense inflammation and contribute to development of dry eye condition. We are confident that our new approach targeting inflammasome pathway and lacrimal gland progenitor cells will lead to development of a new therapies that improve lacrimal gland function during chronic inflammation.

PI_NAMEs: MAKARENKOVA, HELEN P. (contact)

PROGRAM_OFFICER_NAME: MCKIE, GEORGE ANN

PROJECT_TERMS: Acinar Cell;Acinus organ component;Acute;Adult;Affect;American;Anti-Inflammatory Agents;aqueous;Autoimmune;Blurred vision;Caspase;Cell Differentiation process;Cell Lineage;Cell Physiology;Cell Polarity;cell replacement therapy;Cell Transplantation;Cells;Chronic;cytokine;Data;density;Development;diphtheria toxin fragment A;Disease;disease model;donor stem cell;Dry Eye Syndromes;Dryness;effective therapy;endogenous stem cells;Engraftment;Epithelial Cells;epithelial stem cell;Etiology;experimental study;Eye diseases;eye dryness;Eye Infections;Film;Fluids and Secretions;Functional disorder;functional improvement;functional restoration;Gene Expression;Genes;Genetic;Gland;Glycoproteins;Human;IL18 gene;Impairment;improved;in vivo;Infection;Inflammasome;Inflammation;Inflammatory;Inflammatory Response;injured;Injury;Interleukin-1 beta;Ion Channel;Label;Lacrimal gland structure;Link;Lymphocytic Infiltrate;Maintenance;Mediating;Molecular;mouse model;Multiprotein Complexes;Mus;Myoepithelial cell;Natural regeneration;Nature;novel strategies;novel therapeutics;Organ;Pathway interactions;postnatal;Production;progenitor;promoter;Publishing;Recovery of Function;regenerative cell;repaired;Reserve Cell;Reserve Stem Cell;response;Risk;RNA Interference;Role;Sjogren's Syndrome;stem;stem cell biology;stem cell function;stem cell niche;stem cell therapy;Stem cell transplant;stem cells;symptom treatment;Symptoms;System;targeted treatment;Testing;Therapeutic;Thrombospondin 1;Time;Tissues;Transplantation;United States

PROJECT_TITLE: Lacrimal Gland Repair Using Progenitor Cells


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Drug Abuse (NIDA only);Eye Disease and Disorders of Vision;Machine Learning and Artificial Intelligence;Neurosciences;Substance Misuse

PI_NAMEs: FIETE, ILA R. (contact)

PROJECT_TERMS: Accounting;Anatomy;Animals;Architecture;Attention;Bar Codes;Behavior;Behavioral;Benchmarking;Biological;Brain;Brain region;cell type;Collaborations;Communication;Coupled;Data;Data Analyses;data sharing;Decision Making;design;Development;Dimensions;Electrophysiology (science);Environment;Experimental Designs;Experimental Models;experimental study;Future;Genetic Markers;Goals;Infrastructure;International;Laboratories;Learning;learning strategy;Left;Link;Measurement;Methods;Modeling;Mus;network models;neural;neural circuit;neural model;Neural Network Simulation;neuromechanism;novel;operation;Output;Performance;Population;predictive modeling;Process;projectin;recurrent neural network;Regional Anatomy;Research Personnel;Rewards;Running;Sensory;sensory input;Standardization;Statistical Data Interpretation;Statistical Models;Stimulus;Structure;Synapses;synergism;Task Performances;Testing;theories;tool;Training;Work

PROJECT_TITLE: Mechanistic neural circuit models and principles


ED_INST_TYPE: SCHOOLS OF PHARMACY

ORG_CITY: Columbus

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Narrative The proposed research is relevant to public health because an improved understanding of which cancer patients are most likely to benefit from immune checkpoint inhibitor therapy and why some patients do not respond to treatment will lead to meaningful improvements in therapy selection and new strategies for overcoming therapeutic resistance. Research shows a clear link between elevated immune checkpoint inhibitor clearance and poor response that is decoupled from circulating levels of therapeutic in some patients. A better mechanistic understanding of patient factors governing elevated immune checkpoint inhibitor clearance could have a major impact on cancer related mortality by improving utilization of immune checkpoint inhibitor therapy.

PI_NAMEs: COSS, CHRISTOPHER C.;MACE, THOMAS A;OWEN, DWIGHT H.;PHELPS, MITCH A (contact)

PROGRAM_OFFICER_NAME: OLKHANUD, PUREVDORJ BALJINNYAM

PROJECT_TERMS: advanced disease;Affect;Albumins;Animal Model;anti-PD1 therapy;anti-tumor immune response;antigen processing;Antitumor Response;Biological Markers;biomarker selection;Body Weight decreased;Bone Marrow;Bone Marrow Cells;Cachexia;Cancer Cachexia;cancer cell;Cancer Etiology;Cancer Patient;Catabolism;Cells;Cessation of life;checkpoint therapy;Clinical;Clinical Pharmacology;Clinical Trials;Colon Carcinoma;Combined Modality Therapy;CTLA4 gene;cytokine;Data;Dendritic Cells;Homeostasis;Hypoalbuminemia;IgG1;IgG4;Immune;Immune checkpoint inhibitor;Immune Evasion;Immune system;Immunoglobulin G;Immunologic Surveillance;Immunosuppression;improved;in vivo evaluation;Laboratories;Link;Liver;Macrophage;Malignant neoplasm of lung;Malignant neoplasm of pancreas;Malignant Neoplasms;Mediating;Mediator;Melanoma;Methods;Monoclonal Antibodies;monocyte;mortality;mouse model;Mus;Myelogenous;Myeloid Cells;neonatal Fc receptor;neoplastic cell;Non-Small-Cell Lung Carcinoma;Organ;Outcome;Patient Selection;Patients;pembrolizumab;Phenotype;Play;Population;Probability;programmed cell death ligand 1;programmed cell death protein 1;Proteins;Public Health;Publishing;receptor;Recycling;Research;Resistance;response;Role;Selection for Treatments;Serum;Signal Transduction;standard of care;T-cell receptor repertoire;Testing;Therapeutic;therapeutic target;therapy resistant;Tissues;treatment response;tumor;Tumor Immunity;United States;Variant

PROJECT_TITLE: Cachexia-mediated FcRn Modulation and Its Impact on Anti-PD1 Therapy in Lung Cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-D(08)F]


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Eye Disease and Disorders of Vision;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Substance Misuse

PI_NAMEs: CHURCHLAND, ANNE KATHRYN (contact)

PROJECT_TERMS: Affect;Animals;Area;association cortex;autism spectrum disorder;Behavior;Behavioral;behavioral impairment;behavioral study;Brain;Brain region;Communication;Corpus striatum structure;Cues;Data Analyses;data integration;Data Science Core;Decision Making;Dimensions;Disease;Environment;Equilibrium;expectation;experimental study;flexibility;Future;Genetic;genetic manipulation;Goals;Hand;Harvest;Histology;Image;Individual;Infrastructure;insight;International;Investments;Laboratories;large datasets;Lead;Learning;Left;Location;Mathematics;Measurement;Measures;Memory;model of autism spectrum disorder;Modeling;Molecular;mouse model;Movement;Mus;neural;neural circuit;neural correlate;neural patterning;neuromechanism;Neurons;Pattern;Perception;Population;Probability;Property;Reporting;Research;Resolution;Resources;response;Rewards;Sensory;Shapes;Specific qualifier value;Standardization;statistics;Stimulus;Structure;Surveys;Synapses;Techniques;Testing;Time;tool;Training;Update;Visual;Work

PROJECT_TITLE: Learning as a window into how internal states influence decision-making


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences

ORG_CITY: PASADENA

ORG_NAME: CALIFORNIA INSTITUTE OF TECHNOLOGY

PHR: PROJECT NARRATIVE This project focuses on understanding how brain circuits critical for memory formation balance the need to preserve prior knowledge with the necessity to continuously learn new information. The balance between stability and plasticity may be disrupted in aging and in brain disorders such as Alzheimer's disease, and this project will provide a quantitative basis for studying such imbalance and its consequences.

PI_NAMEs: DOYLE, JOHN C;LOIS, CARLOS ;LUBENOV, EVGUENIY VASSILEV;SIAPAS, ATHANASSIOS  (contact)

PROGRAM_OFFICER_NAME: DAVID, KAREN KATE

PROJECT_TERMS: Address;Affect;Aging;Alzheimer's Disease;Animal Behavior;Animals;Area;artificial neural network;Behavior;Behavioral;Biological;Brain;Brain Diseases;Brain region;Cells;Characteristics;Code;Cognition;Cognitive;Computer Models;dynamical evolution;Electrophysiology (science);Environment;Episodic memory;Equilibrium;Evolution;experience;experimental study;Face;Fire - disasters;Gene Expression;Goals;hippocampal pyramidal neuron;Hippocampus;Image;Immediate-Early Genes;indexing;Individual;Knowledge;Learning;learning progression;Location;Maintenance;Maps;Measures;Memory;memory consolidation;memory encoding;Modality;Modeling;Nature;neural;Neuronal Plasticity;Neurons;novel;novel strategies;optogenetics;Pattern;Physical environment;Physiological;Physiology;place fields;Play;Population;preservation;Process;Property;Resources;Rest;Rodent;Role;Sleep;Study models;System;Technology;theories;Time;Training;Visit;Wakefulness;Work

PROJECT_TITLE: Stability and Robustness of Hippocampal Representations of Space


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: MORGANTOWN

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: WEST VIRGINIA UNIVERSITY

ORG_STATE: WV

PHR: West Virginia has the lowest life expectancy in the nation and ranks at or near the bottom in many chronic disease categories. The overarching goal of the West Virginia Clinical and Translational Science Institute is to grow research that accelerates delivery of solutions to health disparities in West Virginia.

PI_NAMEs: HODDER, SALLY LYNN (contact)

PROGRAM_OFFICER_NAME: BISSONETTE, GREG

PROJECT_TERMS: 2019-nCoV;Academic Medical Centers;Acceleration;addiction;Address;Alzheimer's Disease;Appalachian Region;Award;Cardiovascular Diseases;Categories;Chronic Disease;Chronic lung disease;Clinical;Clinical Research;Clinical Sciences;cohort;Cohort Studies;Collaborations;Color;Communication;Communities;community engagement;Community Outreach;County;COVID-19;COVID-19 pandemic;COVID-19 patient;Death Rate;Development;Environmental Hazards;equity, diversity, and inclusion;Exposure to;Funding;Goals;Grant;Health;health care service organization;health disparity;Health Resources;HIV;Human;Human Resources;improved;Incidence;Institution;Lead;Leadership;Life Expectancy;Malignant Neoplasms;Medical center;medical schools;National Institute for Occupational Safety and Health;new epidemic;next generation;Osteopathic Medicine;Outcome;Policies;Positioning Attribute;Post-Acute Sequelae of SARS-CoV-2 Infection;practice-based research network;predictive modeling;Primary Care;Productivity;programs;Public Health;Publications;Registries;reproductive;Research;Research Infrastructure;Research Personnel;Rural Community;Rural Health;Rural Population;Science;Scientist;Site;substance use;Substance Use Disorder;success;Testing;Training;Translational Research;translational scientist;Trust;United States;United States Department of Veterans Affairs;United States National Institutes of Health;West Virginia;Work

PROJECT_TITLE: West Virginia Clinical and Translational Science Institute: A Statewide Organization Building Research Excellence and Engaging Communities to Improve Health


ORG_CITY: PORTLAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Narrative We recently discovered a new way of how signalling lipids are transported in cells. We will fully characterize the components of this exciting new mechanism and will expand the investigations to many other cellular lipids. This work will be the basis for determining the relevance of our findings for cellular signalling and will ultimately identify new drug targets for treating diseases such as cancer and multiple sclerosis.

PI_NAMEs: SCHULTZ, CARSTEN  (contact)

PROGRAM_OFFICER_NAME: ASLAN, KADIR

PROJECT_TERMS: Address;Agonist;Alkynes;Binding;Binding Proteins;Biochemical;Biology;Biophysics;cancer biomarkers;Carrier Proteins;Cell membrane;Cell Physiology;Cells;Cellular Assay;Cellular biology;Charge;Chemicals;Chemistry;Communities;comparative;crosslink;Cytosol;Data;Diazomethane;Disease;Epidermal Growth Factor Receptor;Exhibits;experimental study;Fatty Acids;Funding;Future;Genes;Genetic;Glycerol;Glycerophospholipids;Goals;Head;hydrophilicity;Hydrophobicity;Image;improved;In Vitro;insight;Interphase;Investigation;knock-down;Learning;Light;Lipid Binding;lipid transport;lipidomics;Lipids;lipophilicity;Location;Malignant Neoplasms;Mass Spectrum Analysis;Membrane;Membrane Proteins;Metabolism;metastatic colorectal;Methods;Microscopy;Monitor;Multiple Sclerosis;myelination;new therapeutic target;optogenetics;Outcome;Parents;Pathology;PH Domain;Phenotype;phosphatidylinositol 3,4,5-triphosphate;phosphatidylinositol 3,4-diphosphate;Phosphatidylinositols;Play;Point Mutation;Positioning Attribute;protein purification;Proteins;Proteomics;Publishing;receptor;Receptor Cell;Recombinant Proteins;Resources;retrograde transport;Role;Series;Signal Transduction;Site;Small Interfering RNA;Specificity;success;Techniques;Testing;tool;Travel;Vertebral column;Work

PROJECT_TITLE: Cellular lipid transport determined with multifunctional lipid derivatives

STUDY_SECTION: SBCB

STUDY_SECTION_NAME: Synthetic and Biological Chemistry B Study Section[SBCB]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Contraception/Reproduction;Genetics;Human Genome;Infertility;Pediatric;Pregnancy

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: NARRATIVE This project will apply innovative new techniques on very large existing datasets to help discover novel genetic contributors to spontaneous and recurrent pregnancy loss. We will bring together a remarkable team of leaders across maternal fetal medicine and genomics to assemble the largest cohort of pregnancy loss samples in the field and use high-resolution genomics methods to identify genes and variants that are incompatible with life. We will integrate genes associated with PL to those discovered in other developmental disorders to find key putative drivers of normal development and perform lethality screens of the most compelling novel discoveries using CRISPR genome editing in developing mouse embryos.

PI_NAMEs: TALKOWSKI, MICHAEL E (contact);WAPNER, RONALD ;WILKINS-HAUG, LOUISE

PROGRAM_OFFICER_NAME: ILEKIS, JOHN V

PROJECT_TERMS: aggregation database;algorithm development;analytical method;Architecture;autism spectrum disorder;Bayesian Modeling;Bioinformatics;case control;Child;Chromosome abnormality;Classification Scheme;Clinical;clinical database;clinically relevant;cloud based;Clustered Regularly Interspaced Short Palindromic Repeats;Code;cohort;Comparative Genomic Analysis;Complex;Computer Models;Conceptions;Couples;CRISPR screen;CRISPR/Cas technology;Data;Data Aggregation;data integration;Data Set;de novo mutation;Development;developmental disease;Disease;dosage;early pregnancy loss;Embryo;Emerging Technologies;Engineering;Enhancers;Etiology;Family;fetal;fetal loss;Funding;Future;gene discovery;Generations;Genes;Genetic;genetic architecture;Genetic Predisposition to Disease;Genome;genome editing;Genome engineering;genome sequencing;genomic data;genomic predictors;Genomic Segment;genomic variation;Genomics;Gestational Age;Goals;Heterozygote;Human;Human Development;Human Genome;improved;in vivo;in vivo Model;Individual;innovation;Institution;Intellectual functioning disability;International;Joints;Life;Live Birth;Manuals;Maternal-fetal medicine;Measures;Mediating;Medical Genetics;Mendelian disorder;Methods;Modeling;Molecular;mouse genome;Mus;Mutation;Neurodevelopmental Disorder;non-genetic;novel;Pathogenicity;Penetrance;Phenotype;pleiotropism;Point Mutation;Population;Pregnancy;Pregnancy loss;Process;promoter;Property;prospective;Proteins;Recurrence;Relative Risks;Resolution;Risk Estimate;Sampling;screening;Site;Source;Statistical Models;stillbirth;Structural defect;Tail;Techniques;Technology;technology development;transmission process;Untranslated RNA;Validation;Variant;Work

PROJECT_TITLE: The Genomic Architecture of Pregnancy Loss


NIH_SPENDING_CATS: Drug Abuse (NIDA only);Eye Disease and Disorders of Vision;Genetics;Neurosciences;Substance Misuse

PI_NAMEs: ZADOR, ANTHONY M (contact)

PROJECT_TERMS: anatomical tracing;Anatomy;Animals;Area;Auditory area;Axon;Bar Codes;Behavioral;Brain;Brain region;cell type;Cells;Communication;Complex;Data;Data Analyses;data management;Decision Making;design;DNA;Evaluation;experimental study;Gene Expression;Gene Expression Profiling;Genes;Genetic Markers;Genetic Transcription;Goals;Image;In Vitro;in vivo;in vivo calcium imaging;in vivo two-photon imaging;Individual;insight;International;Knowledge;Laboratories;Light;Measures;Mediating;member;Methods;Modeling;multi-electrode arrays;Mus;neural circuit;Neuroanatomy;neuromechanism;Neurons;novel;Pattern;Physiological;Property;Resolution;Structure;Synaptic Transmission;Techniques;Testing;Tissues;transcriptome;transcriptomic profiling;transcriptomics;transmission process;two-photon;Work

PROJECT_TITLE: Cell-type-specific control of information flow between brain regions


ED_INST_TYPE: HOSPITALS

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Cancer;Uterine Cancer;Women's Health Research

ORG_CITY: HOUSTON

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: PROJECT NARRATIVE This program is especially relevant to Public Health as it gives gynecologic oncology fellows the opportunity to train to become physician-scientists or population-based investigators. As the population ages and the number of oncologists declines, this program is critical to help meet future demands for oncology services and training the next generation of academic gynecologic oncologists.

PI_NAMEs: SCHMELER, KATHLEEN ;SOLIMAN, PAMELA ;SOOD, ANIL K (contact)

PROGRAM_OFFICER_NAME: BOULANGER-ESPEUT, CORINNE A

PROJECT_TERMS: Gynecologic Oncologist;Training

PROJECT_TITLE: Training of Academic Gynecologic Oncologists

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Estrogen;Neurosciences;Prevention;Substance Misuse;Women's Health Research

ORG_DEPT: PSYCHIATRY

PHR: PROJECT NARRATIVE The findings from this project will determine sex differences and the influence of sex hormones on neural function underlying risk for Alcohol Use Disorder (AUD), as well as how sex differences in neural function influence current and future alcohol consumption. The results will identify novel brain-based targets for sex- specific prevention and treatment efforts for AUD, and will provide information on the optimal timing of intervention for women, based on fluctuating sex hormones. As such, the project is a critical step towards the development of biologically-based, sex-specific interventions for AUD.

PI_NAMEs: WEAFER, JESSICA J (contact)

PROGRAM_OFFICER_NAME: GRAKALIC, IVANA

PROJECT_TERMS: addiction;Alcohol abuse;alcohol abuse therapy;Alcohol consumption;alcohol cue;alcohol intervention;alcohol risk;alcohol use disorder;Alcohols;Amygdaloid structure;Anterior;Area;Brain;brain based;career;cingulate cortex;Corpus striatum structure;cue reactivity;Data;design;Development;disorder risk;drinking;Emotional;Estradiol;executive function;Female;follow-up;Functional Magnetic Resonance Imaging;functional MRI scan;Future;Goals;Gonadal Steroid Hormones;hazardous drinking;Heavy Drinking;Hormonal;incentive salience;Inferior frontal gyrus;innovation;Insula of Reil;Intervention;Intravenous;Laboratories;Link;Luteal Phase;Maintenance;male;Measures;Medial;men;Menstrual cycle;Modeling;Motor;negative affect;Negative Finding;neural;neural circuit;neural correlate;Neurobiology;Neurophysiology - biologic function;novel;Participant;Patient Self-Report;Pattern;Pharmacotherapy;Phase;Prefrontal Cortex;Prevention;Progesterone;proliferative phase Menstrual cycle;prospective;Research;Research Personnel;Risk;Risk Factors;Scanning;Self Administration;sex;Sex Differences;Signal Transduction;skills;Smoker;stimulant user;Transcranial magnetic stimulation;Woman;women versus men;young woman

PROJECT_TITLE: Sex Differences in Risk for Alcohol Use Disorder: Neural and Hormonal Influences


NIH_SPENDING_CATS: Kidney Disease

ORG_CITY: DAYTON

ORG_DEPT: PHYSIOLOGY

ORG_NAME: WRIGHT STATE UNIVERSITY

PHR: Project Narrative As our understanding of calcineurin signaling grows, we are able to elucidate the molecular mechanisms contributing to CNI-induced renal fibrosis. Our project goal is to test the hypothesis that renal CnAα inhibition upregulates NFκB signaling which promotes irreversible renal damage. These findings have clinical relevance and advance the field of renal physiology and pharmacology and pursues the idea that newer CNIs can be developed that effectively blunt the immune response while reducing or preventing kidney damage.

PI_NAMEs: UME, ADAKU  (contact)

PROGRAM_OFFICER_NAME: MARIC-BILKAN, CHRISTINE

PROJECT_TERMS: Advocate;Applications Grants;Atopic Dermatitis;Biological Assay;Calcineurin;Calcineurin inhibitor;Calmodulin;Catalytic Domain;Cell Physiology;Cell Survival;clinically relevant;Communication;Complex;Critical Thinking;Cyclosporine;Data;Development;Drug Screening;Drug toxicity;End stage renal failure;Event;experience;experimental study;Fibroblasts;Fibronectins;Fibrosis;Future;Genes;Goals;Immune response;Immunity;Immunosuppression;improved;in vivo;Inflammatory;inhibitor;inhibitor therapy;Injury;Injury to Kidney;insight;interest;interstitial;Kidney;kidney cortex;kidney dysfunction;Kidney Failure;kidney fibrosis;Kidney Transplantation;Knowledge;Lupus Nephritis;Measures;Mediating;Mediator;Methods;Molecular;Morphology;Mus;mutant;Nephrology;nephrotoxicity;NF-kappa B;NF-kappaB-inducing kinase;novel;Organ Transplantation;Outcome;Pathogenesis;Pathway interactions;Patient Care;Patients;Persons;Pharmaceutical Preparations;pharmacologic;Pharmacologic Substance;Pharmacology;Phosphorylation;Phosphotransferases;Physiology;Plasmids;post-transplant;PPP3CA gene;prevent;Process;Protein Dephosphorylation;Protein Isoforms;Proteins;Regulation;renal damage;Renal function;Research;Research Personnel;Role;side effect;Signal Pathway;Signal Transduction;skills;success;Tacrolimus;Testing;Therapeutic;Therapeutic immunosuppression;Tissues;Toxic effect;transcription factor;Transforming Growth Factor beta;Up-Regulation;virtual;Work;Writing

PROJECT_TITLE: The role of NFkB in calcineurin inhibitor-induced renal fibrosis


NIH_SPENDING_CATS: Bioengineering;Biotechnology

ORG_CITY: Princeton

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: PRINCETON UNIVERSITY

ORG_STATE: NJ

PHR: PROJECT NARRATIVE Cell signaling proteins such as the Erk kinase play a crucial role in embryo development, cancer, and the developmental defects known as RASopathies. A major hypothesis in the field is that cell adopt different fates depending on whether Erk is activated in a short pulse or a long plateau, but studying these dynamics remains extremely difficult. We propose to develop a new class of biosensors for detecting signaling pulses from Erk and other pathways, opening the door to a better understanding of their role in development and disease.

PI_NAMEs: TOETTCHER, JARED E (contact)

PROGRAM_OFFICER_NAME: YEH, ALVIN TIEN-WEI

PROJECT_TERMS: Address;Adopted;Adult;Animals;Awareness;Biochemical;Biological Models;Biosensor;Cell Differentiation process;cell fixing;Cell Surface Receptors;cell type;Cells;Chemicals;combinatorial;Communication;Complex;Coupled;Cues;Cultured Cells;Defect;design;Detection;detection platform;detector;Development;Discrimination;Disease;dynamic system;Embryonic Development;Environment;Exhibits;extracellular;Genes;Genetic Screening;Goals;Growth;Growth Factor;Homeostasis;Human Cell Line;human disease;Image;improved;in vivo;Individual;invention;Label;Lead;Ligands;live cell microscopy;Malignant Neoplasms;Mammalian Cell;Maps;Measurement;Measures;Membrane;Microscopy;Modality;Monitor;Mouse Cell Line;Mouse Strains;Mutation;network architecture;new technology;NF-kappa B;Nutrient;Organ;Organogenesis;Output;Pathway interactions;Pattern;Phenotype;Phosphotransferases;Physiologic pulse;Physiology;Play;prevent;promoter;Proteins;prototype;ras Proteins;recombinase;Research Personnel;Resolution;response;Role;Signal Pathway;Signal Transduction;Signaling Protein;Stress;success;Syndrome;System;Technology;Testing;Time;tissue regeneration;Tissues;tool;TP53 gene;Transcriptional Activation;Transgenic Animals;Translational Repression;Travel;tumor;tumorigenesis;Variant;Work;wound healing

PROJECT_TITLE: A new class of biosensors for detecting signaling dynamics without live-cell microscopy

STUDY_SECTION: CMT

STUDY_SECTION_NAME: Cellular and Molecular Technologies Study Section[CMT]


NIH_SPENDING_CATS: Cancer

PI_NAMEs: CHRISTENSON, TERESA  (contact)

PROJECT_TERMS: Agreement;Budgets;Calendar;Cancer Center;Cancer Center Support Grant;Child;Cities;Clinical Trials;Collaborations;Communication;Contracts;cost effective;Development;Education;Ensure;Evaluation;Event;experience;Fostering;Funding;Grant;Human Resources;Information Dissemination;Information Technology;Kansas;Leadership;Malignant Neoplasms;Medical center;Medical Research;member;outreach;Pilot Projects;Productivity;programs;Public Policy;Public Relations;Publications;recruit;Reporting;Research;Resource Sharing;Resources;social communication;social media;Strategic Planning;Trademark;Universities;Vision;web site

PROJECT_TITLE: Cancer Center Administration Core


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Substance Misuse

ORG_CITY: COLUMBIA

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

ORG_STATE: MO

PHR: Project Narrative “Extreme” drinking (roughly a “double” binge) is a significant public health concern, especially among young adults, but almost all information on these behaviors is based on self‐report, which can be particularly unreliable given the memory impairments associated with this level of alcohol consumption. This project will collect data from high risk young adults during drinking events using mobile technology, including real‐time smartphone assessments and portable alcohol breathalyzers, and will be combined with information from other sources (e.g., alcohol outlet density, laboratory collected data). Results of this study can provide unique information critical to developing public health messages and interventions aimed at reducing extreme drinking.

PI_NAMEs: MCCARTHY, DENIS M;SHER, KENNETH JAMES;TRULL, TIMOTHY J (contact)

PROGRAM_OFFICER_NAME: ZHA, WENXING

PROJECT_TERMS: absorption;addiction;Adult;adverse outcome;Age;alcohol behavior;Alcohol consumption;alcohol exposure;alcohol measurement;alcohol outlet density;alcohol poisoning;alcohol related consequences;Alcohols;Attention;Behavior;Behavior assessment;binge drinker;binge drinking;Blood alcohol level measurement;Cellular Phone;Chronic;Consumption;contextual factors;craving;Cross-Sectional Studies;Cues;Data;Databases;density;design;Diagnosis;Dimensions;Dose;drinking;drinking behavior;Ecological momentary assessment;Economic Burden;Electrophysiology (science);Elements;Environment;Epidemiology;Ethics;Event;Frequencies;Genetic;Genotype;Health;Heavy Drinking;high intensity drinking;high risk;high risk drinking;Hour;Impulsivity;incentive salience;indexing;Individual;Individual Differences;Intervention;Investigation;Knowledge;Laboratories;Laboratory Study;Legal;Life;Limb structure;Longitudinal Studies;Measures;Memory impairment;men;Methods;Minority;mobile computing;Modality;Modeling;Moods;negative affect;new technology;Participant;Patient Self-Report;Personality;Phenotype;polygenic risk score;portability;Process;prospective;Public Health;Questionnaires;recruit;Recurrence;Research;Rewards;Risk;Sampling;Severities;Societies;Source;substance use;Surveys;Testing;Theoretical model;therapeutic target;Time;trait;Woman;young adult

PROJECT_TITLE: A Multi-Method Study of Extreme Alcohol Drinkers in the Lab and in Real-Life: Increasing Precision of Assessments of Extreme Drinking Determinants


NIH_SPENDING_CATS: Biotechnology;Hematology;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

PHR: Project Narrative Hematopoietic stem cells (HSCs) are the self-renewing population of cells that generate all the blood lineages throughout the life of an organism and are biomedically important as the basic units of bone marrow transplantation, which is used to treat a myriad of malignant and non-malignant hematological diseases. This proposal aims to characterize a family of novel regulators (GPRASPs) of HSCs and their role in HSC transplantation, which will illuminate a new set of molecular candidates that might be targeted for improving current therapies.

PI_NAMEs: MORALES-HERNANDEZ, ANTONIO  (contact)

PROGRAM_OFFICER_NAME: HATTANGADI, SHILPA MANOHAR

PROJECT_TERMS: Affect;B cell differentiation;B-Lymphocytes;Behavior;Binding;Blood;Bone Marrow Transplantation;Cell Compartmentation;Cell Count;Cell Cycle;Cell Lineage;cell stroma;Cells;curative treatments;CXCR4 gene;Data;differential expression;Disparate;Engraftment;Ensure;Environment;Erythrocytes;Family;Family member;G-Protein-Coupled Receptors;Gene Expression;Gene Expression Profile;gene therapy;Genetic;Goals;Hematological Disease;Hematopoiesis;Hematopoietic;Hematopoietic Stem Cell heterogeneity;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;Hematopoietic System;Heterogeneity;High Dose Chemotherapy;Homing;Immunofluorescence Immunologic;Impairment;improved;in vivo;Individual;Institution;leukemia;Leukocytes;Life;Link;Lymphoid;Malignant - descriptor;Mediating;Mentors;Modeling;Molecular;Molecular Target;Natural regeneration;Non-Malignant;novel;novel marker;Organism;Patients;pharmacologic;Phase;Phenocopy;Phenotype;Population;post-transplant;Procedures;Production;progenitor;Proliferating;Protein Family;Protein Sortings;reconstitution;Regulation;Reporter;Resources;Role;Safety;Saint Jude Children's Research Hospital;self renewing cell;Signal Transduction;single cell analysis;stem cell engraftment;stem cell function;stem cells;stemness;Stress;Stromal Cell-Derived Factor 1;success;therapeutic target;tool;trafficking;Transplantation;transplantation therapy;Umbilical Cord Blood;Work

PROJECT_TITLE: GPRASP family as novel regulators in hematopoietic stem cells

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


PI_NAMEs: WELCH, DANNY R. (contact)

PROJECT_TERMS: Advocate;anti-cancer research;Area;Award;Basic Science;Biometry;Cancer Biology;Cancer Burden;cancer care;Cancer Center;cancer education;care providers;career;career development;Catchment Area;certificate program;Child;Cities;Clinical;Clinical Sciences;Collection;Communities;community engagement;Community Outreach;Continuing Education;continuing nursing education;Dedications;Development;Discipline;Discipline of Nursing;Doctor of Philosophy;Education;Education and Outreach;education research;Educational Curriculum;Ensure;Environment;Equity;experience;Extramural Activities;Faculty;Family;Fellowship;Funding;graduate student;Grant;health care delivery;Health Occupations;Health Professional;Healthcare;Healthcare Systems;high school;improved;Infrastructure;Institution;Kansas;Knowledge;Laboratory Research;Leadership;life-long learning;Malignant Neoplasms;Manuscripts;Medical;Medical center;Medical Research;Medical Students;member;Mentors;metropolitan;novel therapeutic intervention;Nurses;Outcome;Participant;Patients;peer;Physicians;population based;Population Heterogeneity;Population Sciences;Postdoctoral Fellow;pre-doctoral;Preparation;Prevention strategy;programs;Publications;Research;Research Personnel;Resource Sharing;Science;Science, Technology, Engineering and Mathematics Education;success;summer program;Systems Integration;teacher;Training;Training and Education;Translational Research;Translations;Travel;undergraduate research;undergraduate student;Underrepresented Populations;Underrepresented Students;Universities;Vision;Work

PROJECT_TITLE: Cancer Research Training & Education Coordination CRTEC


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Rural Health

PROJECT_TERMS: Accountability;Agreement;Award;Clinical;Clinical Research;Clinical Sciences;Clinical Trials;Collaborations;Communication;Communities;community engagement;Coordination and Collaboration;Creativeness;Data Analytics;Decision Making;driving performance;empowerment;Ensure;Environment;Event;experience;Faculty;flexibility;Funding;Goals;Health;health disparity;improved;Infrastructure;Institution;Leadership;Link;Medical center;member;operation;organizational structure;Performance;Policies;Problem Solving;Procedures;Process;Productivity;programs;Provider;Publications;Research;Research Infrastructure;Research Personnel;Resources;Rural;Seasons;Services;Site;sound;Structure;Translational Research;translational scientist;United States Dept. of Health and Human Services;Universities;Veterans;West Virginia;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Rural Health

PI_NAMEs: DEVRIES, ANNE COURTNEY (contact)

PROJECT_TERMS: academic program;Academy;Address;Applications Grants;Area;Award;Biomedical Engineering;Businesses;career;career development;Clinical;Clinical Investigator;Clinical Psychology;Clinical Research;Clinical Sciences;Clinical Trials;Communication;Communities;community engagement;computer science;COVID-19;COVID-19 pandemic;Degree program;Development;digital;Discipline;Doctor of Pharmacy;Doctor of Philosophy;Economics;editorial;Educational workshop;empowerment;Ensure;experience;Faculty;Fellowship;Female;Fostering;Foundations;Funding;Goals;Graduate Degree;Grant;Health;health disparity;Health Occupations;Hybrids;improved;Individual;Institution;interest;Knowledge;Leadership;learning community;Manuscripts;medical specialties;medically underserved;meetings;member;Mentors;Mentorship;Modeling;next generation;Participant;Peer Review;Persons;Principal Investigator;Productivity;programs;Publications;Recruitment Activity;Research;Research Activity;research and development;Research Institute;Research Personnel;Research Project Grants;Research Support;Rural Appalachia;Rural Community;Scholars Program;Schools;Science;Series;service programs;Services;Site;skill acquisition;skills;Solid;Structure;success;Support System;symposium;Talents;Time;Training;Training Programs;Translational Research;translational scientist;underserved community;virtual;webinar;West Virginia;working group;Writing

PROJECT_TITLE: Professional Development Core


NIH_SPENDING_CATS: Cancer;Prevention;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

PI_NAMEs: NEUFELD, KRISTI L (contact)

PROJECT_TERMS: Affect;Basic Science;Behavior;bench to bedside;Biochemical;Biochemistry;Biological;Biological Markers;Bladder;Breast;Cancer Biology;cancer cell;Cancer Center;Cancer Center Support Grant;cancer prevention;cancer therapy;cancer type;Catchment Area;cell behavior;cell growth;Cell Proliferation;Cell Survival;Cells;Cellular biology;cellular targeting;Cessation of life;Child;Clinical;clinical development;cohesion;Collaborations;Communities;Development;diagnostic strategy;Discipline;Disease;Distant;DNA Damage;experience;Fostering;Funding;gastrointestinal;Genes;Genetic;Genotoxic Stress;Goals;Hematologic Neoplasms;Hematopoietic System;improved;Institution;interdisciplinary collaboration;International;Invaded;Journals;Kansas;Kidney;Leadership;Liver;Malignant - descriptor;Malignant neoplasm of gastrointestinal tract;Malignant Neoplasms;Medical center;Medical Research;meetings;member;Methods;model organism;Molecular;multidisciplinary;NCI-Designated Cancer Center;Neoplasm Metastasis;neoplastic cell;Normal Cell;novel;novel strategies;Organ;Outcome;Pancreas;Paper;Pathway interactions;Peer Review;preclinical development;Prevention strategy;Process;programs;Publications;Publishing;Quality of life;recruit;Regulation;repaired;Research;Research Personnel;response;Signal Pathway;Signal Transduction;stem cell biology;stem cells;Strategic Planning;symposium;Therapeutic;therapy development;therapy resistant;Tissues;Tobacco-Related Carcinoma;Translating;Translational Research;translational research program;tumor;Tumor Cell Biology;tumor growth;tumor initiation;tumor microenvironment;tumor progression;Tumor Stem Cells;United States National Institutes of Health;Universities

PROJECT_TITLE: Cancer Biology Program


ADMINISTERING_IC: EB

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Clinical Research;Pediatric

ORG_CITY: FAYETTEVILLE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF ARKANSAS AT FAYETTEVILLE

ORG_STATE: AR

PHR: PROJECT NARRATIVE  We are transforming our biomedical engineering education by introducing series of courses as part of an educational toolkit for bioengineering design, entrepreneurship, and service learning into our curriculum. This toolkit will consist of four courses, in which students will engage with our local healthcare community to identify healthcare gaps and disparities, learn about entrepreneurship in collaboration with the business school, acquire essential engineering design skills already in their junior year, and inspire the next generation of engineers by mentoring high school pre-engineering students. Our aim is to graduate biomedical engineers who are outstanding stewards of their education, serving their communities, and translating healthcare innovations for a broader impact.

PI_NAMEs: RAO, RAJ RAGHAVENDRA (contact)

PROGRAM_OFFICER_NAME: GUTEKUNST, DAVID JOSEPH

PROJECT_TERMS: Address;Bachelor's Degree;Biology;Biomedical Engineering;Businesses;career;career development;Clinic;Clinical;Collaborations;commercialization;Communities;community engagement;Computer software;computerized tools;Dedications;Degree requirements;design;Development;Disparity;Economic Development;Education;Educational Curriculum;Educational process of instructing;effectiveness evaluation;Engineering;engineering design;Ensure;Entrepreneurship;Environment;Ethics;Evaluation;experience;faculty support;Future;Generations;Geography;Goals;Graduate Degree;graduate student;health disparity;Health Insurance Portability and Accountability Act;Healthcare;healthcare community;high school;Human;ideation;Immersion;innovation;insight;Institution;Intellectual Property;Knowledge;Learning;learning engagement;lectures;Legal patent;Life Experience;Medical;Medicine;Mentors;Mentorship;Modernization;next generation;novel;Output;peer networks;Population;programs;Protocols documentation;prototype;recruit;Research;Role;School-Age Population;Schools;Science;Series;service learning;skills;Social Interaction;student mentoring;Student recruitment;student retention;Students;Technical Expertise;Technology;Technology Assessment;Technology Transfer;tool;Training;Translating;Underrepresented Minority;Universities

PROJECT_TITLE: Educational Toolkit for Bioengineering Design, Entrepreneurship and Service Learning


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Lung Cancer;Obesity;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

PI_NAMEs: ELLERBECK, EDWARD F. (contact)

PROJECT_TERMS: Address;Advocacy;Affect;African American;American Indian community;anti-cancer research;Area;Award;Behavior;Behavioral;behavioral clinical trial;Behavioral Sciences;Biological Markers;Biology;biomarker driven;biomarker identification;Biometry;Breast;cancer biomarkers;Cancer Burden;cancer care;Cancer Center;Cancer Center Support Grant;cancer complication;Cancer Control;Cancer Control Research;Cancer Control Research Program;cancer health disparity;Cancer Patient;cancer prevention;cancer recurrence;cancer risk;Cancer Survivorship;cancer therapy;care delivery;Caring;Catchment Area;Clinical;clinical practice;Collaborations;Communication;Communities;community engagement;Community Outreach;Community Practice;Criminal Justice;Data Science;design;Detection;Development;Diagnosis;Discipline of Nursing;Disease;Disease Marker;Disease Progression;Economics;effective intervention;Ensure;Epidemiology;Equity;evidence base;Evidence based intervention;Exclusion;Extramural Activities;Faculty;Fostering;Funding;gastrointestinal;Grant;Guidelines;Health Services Research;Hereditary Malignant Neoplasm;hereditary risk;high risk;high risk population;Hispanic;Immunization;implementation science;improved;Incidence;Individual;Infrastructure;innovation;Intervention;Intervention Studies;Kansas;Lesion;life span;Malignant Neoplasms;member;Mentorship;Methods;minority communities;Mission;Modeling;Molecular;Morbidity - disease rate;multidisciplinary;National Cancer Institute;neighborhood disadvantage;Neurosciences;novel;nutrition;Nutritional;Obesity;Observational Study;Oncology;Pain management;Pathway interactions;Patients;Persons;pharmacologic;Pharmacology;Phase;Physical activity;physical inactivity;Pilot Projects;Policies;Population;population health;Population Sciences;Populations at Risk;Positioning Attribute;practice setting;Pragmatic clinical trial;pragmatic study;pragmatic trial;premalignant;prevent;Prevention;Primary Cancer Prevention;Primary Care;Primary Prevention;Principal Investigator;Productivity;programs;Provider;Public Health;Publishing;Research;Research Design;Research Personnel;Research Project Grants;Risk;Risk Factors;Rural;Rural Community;Rural Minority;Scholars Program;Schools;Scientific Advances and Accomplishments;Screening for cancer;Services;Smoking;student mentoring;success;support network;survivorship;System;telehealth;Testing;tobacco control;Training;Translating;translational pipeline;Translational Research;Translations;underserved minority;Universities;visiting scholar;Work;working group;Writing

PROJECT_TITLE: Cancer Prevention and Control Program


NIH_SPENDING_CATS: Bioengineering;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Rural Health

PI_NAMEs: WEN, SIJIN  (contact)

PROJECT_TERMS: Achievement;Address;Area;Artificial Intelligence;artificial intelligence algorithm;Attention;Big Data;Bioinformatics;Biometry;centralized portal;certificate program;Certification;Clinical;Clinical Data;clinical imaging;Clinical Research;Clinical Sciences;cluster computing;Code;Collaborations;community engagement;Complex;Computer Systems;Custom;Data;Data Analyses;Data Set;design;Digital Libraries;Documentation;Educational workshop;empowerment;Environment;Epidemiology;Equipment;Funding;Genomics;Geographic Information Systems;Goals;Health;health disparity;Health Insurance Portability and Accountability Act;High Performance Computing;Image;imaging capabilities;improved;Infrastructure;innovation;Institution;Knowledge;Link;Machine Learning;machine learning algorithm;Medical center;Medicine;meetings;Methodology;Methods;Mission;Neighborhoods;next generation;North America;novel;Osteopathic Medicine;Outcome;Patients;personalized medicine;predictive modeling;Process;Productivity;Research;Research Design;Research Infrastructure;Research Personnel;Resources;Running;Rural Population;Sample Size;Schools;Secure;sensor;service learning;Services;Site;spatial integration;Statistical Models;statistics;System;Technology;Time;tool;Training;Training Programs;Translational Research;trend;Universities;Vulnerable Populations;West Virginia

PROJECT_TITLE: Biostatistics, Epidemiology, and Research Design


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Aggregation of the RNA binding protein TDP-43 is found in almost every age-dependent neurodegenerative disease, including the major dementias. We propose to determine how age-dependent decrease in protein folding chaperone and protein degradation activities contribute to TDP-43 loss of function, cytoplasmic mislocalization, phase separation, and aggregation. We will also develop and refine an approach to generate new/replacement neurons in the aged adult brain by transiently suppressing expression of a single protein, the RNA binding protein PTB. We will develop and use single cell spatial transcriptomics to identify the functionality, localization, cell origin, timing, and molecular pathways of the newly developing neurons.

PI_NAMEs: BINTU, BOGDAN ;CLEVELAND, DON W (contact)

PROGRAM_OFFICER_NAME: SHEWMAKER, FRANK PAUL

PROJECT_TERMS: Acute;Adult;Affect;age related;age related neurodegeneration;aged;Aging;Alzheimer's Disease;Antisense Oligonucleotides;assay development;Behavior;Binding Proteins;Brain;C9ORF72;Cell Death;Cells;Central Nervous System;Cerebrospinal Fluid;Chronic;Cytoplasm;Cytoplasmic Granules;Cytoprotection;Dementia;dentate gyrus;Development;Disease;Elderly;Family;Fluorescent in Situ Hybridization;Frontotemporal Dementia;Generations;Glial Fibrillary Acidic Protein;Heat shock proteins;Heat-Shock Proteins 70;Hippocampus;HSPB1 gene;Induced pluripotent stem cell derived human neuron;Injections;Label;limbic-predominant age-related TDP-43 encephalopathy;Liquid substance;loss of function;Mass Spectrum Analysis;Mediating;Molecular;Molecular Chaperones;mouse model;multicatalytic endopeptidase complex;Mus;Mutation;Names;Nervous System;Neuroglia;neuronal replacement;Neurons;normal aging;Nuclear;old mice;Pathway interactions;Phase;Polypyrimidine Tract-Binding Protein;Production;Proteasome Inhibition;protein degradation;protein folding;protein TDP-43;Proteins;Radial;Reporting;RNA;RNA-Binding Proteins;solid state;Stress;Syndrome;TDP-43 aggregation;Therapeutic;Time;Toxic effect;transcriptomics;Work

PROJECT_TITLE: Disease Mechanism and Therapy in TDP-43 Proteinopathies and Dementias

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


NIH_SPENDING_CATS: Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Primary Health Care;Rural Health;Social Determinants of Health

PI_NAMEs: KENNEDY-REA, STEPHENIE KAY (contact)

PROJECT_TERMS: Active Learning;Address;Advisory Committees;Area Health Education Centers;care outcomes;Categories;Chronic Disease;Chronic lung disease;Clinical Research;Clinical Sciences;Clinical Trials;Clinical Trials Unit;cohort;Collaborations;combat;Communication;Communities;community based participatory research;community clinic;community engagement;Community Health;Community Healthcare;community involvement;Community Outreach;community research;Confusion;Consultations;Core Facility;County;COVID-19;design;Development;Emergency response;Ensure;equity, diversity, and inclusion;Event;Evidence based intervention;Evidence based practice;experience;Focus Groups;Fright;Funding;Health;health disparity;health inequalities;Health Personnel;Health Priorities;Health Promotion;Heart Diseases;implementation science;improved;Information Dissemination;Infrastructure;innovation;intersectionality;Intervention;Joints;Learning;Malignant Neoplasms;Measures;Medicaid;medical specialties;member;Mentors;Mentorship;Misinformation;mortality disparity;operation;Outcome;outreach;Patients;peer;Persons;poor health outcome;Positioning Attribute;Poverty;practice-based research network;Primary Care Physician;primary care setting;programs;Provider;Public Health;Race;RADx;Readiness;Recommendation;recruit;Research;research facility;Research Infrastructure;Research Institute;Research Personnel;Research Project Grants;Resources;Rural;rural Americans;rural area;Rural Community;rural dwellers;Rural Health;rural health clinic;Rural Population;rurality;Scholars Program;Science;Scientist;Series;Services;Site;Speed;Spottings;Stroke;Substance Use Disorder;success;Surveys;Testing;Training;Translational Research;Translations;Underserved Population;United States National Institutes of Health;uptake;urban area;Vaccination;virtual group;West Virginia

PROJECT_TITLE: Community Engagement and Outreach Core


PI_NAMEs: SHARMA, PRIYANKA  (contact)

PROJECT_TERMS: Adolescent;Adult;anti-cancer research;Antineoplastic Agents;Applied Research;Area;Basic Science;biomarker discovery;Cancer Center;Cancer Patient;cancer prevention;cancer therapy;Catchment Area;Child;Childhood;Cities;Clinical;Clinical Sciences;Clinical Trials;Collaborations;Competence;design;Detection;Development;Diagnostic;diagnostic development;Discipline;Doctor of Pharmacy;Doctor of Philosophy;Drug Delivery Systems;drug development;drug discovery;Drug Exposure;Drug Targeting;Education;Ensure;Environment;Evaluation;FDA approved;Fostering;Funding;genomic data;Goals;high throughput screening;Human Resources;improved;In Vitro;in vivo;innovation;Institution;invention;Investigational Therapies;Journals;Kansas;Knowledge;Laboratories;Leadership;Malignant Neoplasms;Medical;Medical center;member;Mentors;Mentorship;mid-career faculty;NCI Center for Cancer Research;new technology;novel;novel anticancer drug;novel strategies;novel therapeutics;older patient;patient oriented;Patients;Peer Review;Pharmaceutical Chemistry;Pharmaceutical Preparations;Pharmacogenomics;Pharmacotherapy;precision medicine;preclinical study;prevent;Prevention;Prevention strategy;Productivity;professor;Program Development;programs;Publications;Publishing;Quality of life;Records;Reporting;Research;Research Personnel;Research Project Grants;Resource Sharing;response;Science;Technology;Therapeutic;Therapeutic Agents;Therapeutic Research;Therapeutic Trials;Training;Translational Research;translational scientist;treatment strategy;Universities;Validation;Vision;Work

PROJECT_TITLE: Drug Discovery, Delivery and Experimental Therapeutics Program


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research

PI_NAMEs: RANKIN, GARY O (contact)

PROJECT_TERMS: Acceleration;addiction;Address;Alzheimer's Disease;Applications Grants;Area;bench to bedside;Cardiovascular Diseases;career development;Chronic lung disease;clinical application;Clinical Investigator;Clinical Research;Clinical Sciences;Collaborations;commercialization;community engagement;Conceptions;Data;Development;Educational workshop;Emerging Communicable Diseases;Ensure;experience;Extramural Activities;flexibility;Foundations;Funding;Funding Mechanisms;Funding Opportunities;Future;Goals;Grant;Health;Health Priorities;implementation facilitation;improved;Incentives;Infrastructure;innovation;innovative technologies;Institution;Investigator-Initiated Research;Malignant Neoplasms;Manuscripts;Medical;Medical Students;Mentors;Mission;novel;Outcome;Pathway interactions;Pilot Projects;Positioning Attribute;practice-based research network;Process;programs;Qualifying;Research;Research Personnel;response;Rural Health;Science;Secure;Site;Stroke;success;Technology;Time;Training;Translational Research;translational scientist;Trust;Universities;West Virginia;Work

PROJECT_TITLE: Pilot Projects Program


NIH_SPENDING_CATS: Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Rural Health;Social Determinants of Health

PI_NAMEs: CHEN, RONALD  (contact)

PROJECT_TERMS: Address;Advocate;Affect;anti-cancer research;Antineoplastic Agents;Area;Automobile Driving;Basic Cancer Research;Biometry;Black race;Budgets;Cancer Biology;Cancer Burden;cancer care;Cancer Center;Cancer Control;Cancer Control Research;cancer health disparity;Cancer Patient;cancer prevention;cancer therapy;care delivery;Catchment Area;Charge;Clinical;Clinical Trials;Collaborations;Collection;Communication;Communities;community advisory board;community collaboration;community engaged research;community engagement;community organizations;Community Outreach;community partners;comparative effectiveness;County;Data;data warehouse;Databases;Development;Dissemination and Implementation;drug discovery;Education;Evaluation;Evidence based intervention;experience;Fostering;Funding;Future;Goals;Grant;health equity;Health Policy;Hematologic Neoplasms;Hispanic;Hospitals;improved;Incidence;Individual;Information Systems;Infrastructure;Institution;Investigational Therapies;Kansas;Knowledge;Laboratories;Leadership;Logic;Malignant Breast Neoplasm;Malignant Childhood Neoplasm;Malignant neoplasm of gastrointestinal tract;Malignant neoplasm of prostate;Malignant Neoplasms;member;Mission;Missouri;mobile health clinic;Modeling;Monitor;mortality;NCI Center for Cancer Research;neoplasm registry;novel therapeutics;Obesity;outreach;Patients;Play;Policies;Population;population based;Prevention;Primary Care;programs;Provider;public education;Radiation Oncologist;Recommendation;Research;Research Activity;Research Personnel;Research Support;Risk Behaviors;Role;Rural;rural cancer care;rural patients;Rural Population;Science;Scientist;screening;Screening for cancer;Technology;Therapeutic Agents;Therapeutic Research;Tobacco;Tobacco-Related Carcinoma;Training;trend;Universities;Vision;Work

PROJECT_TITLE: Community Outreach and Engagement COE


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Drug Abuse (NIDA only);Genetics;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Social Determinants of Health;Substance Misuse

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Sexual and gender minority people (including but not limited to people who are LGBTQ+) are at greater risk for substance use, which is related to unique stressors such as stigma and discrimination, and both substance use and this unique stress have biological signatures, suggesting that biological markers of substance use may be developed that could improve substance use treatment. Dr. Flentje proposes to expand her research by integrating hormonal exposures and HIV status into this work, identifying mentees from a range of disciplines including hormonal biology, epigenetics, and HIV, and seeking training to support mentees through financial challenges, loan repayment applications, family building, and emotional hardships. Dr. Flentje will support patient-oriented mentees to identify hormone exposures and stressors relevant to substance use, and identify epigenetic markers of substance use, hormone exposure, and minority stress among people living with or without HIV.

PI_NAMEs: FLENTJE, ANNESA  (contact)

PROGRAM_OFFICER_NAME: LOSSIE, AMY C

PROJECT_TERMS: accelerated epigenetic aging;Accounting;Age;All of Us Research Program;American;Animal Model;Applications Grants;Area;Award;Behavioral Sciences;Bioinformatics;Biological;Biological Markers;Biology;Birth;California;career;Cessation of life;cisgender;Clinical Psychology;Cohort Studies;Community Health Systems;comorbidity;Consent;Data;Data Set;disability;Discipline;Discrimination;Emotional;Environment;epigenetic marker;Epigenetic Process;epigenome;epigenomics;Estrogens;Faculty;family building;Foundations;Funding;Gender;gender affirming hormones;gender minority group;gender minority health;Goals;Gonadal Hormones;Health;health disparity;Heterosexuals;HIV;Hormonal;Hormones;Human;Hydrocortisone;Immune response;improved;Injury;innovation;interest;K-Series Research Career Programs;Lesbian Gay Bisexual Transgender Queer;Longitudinal cohort study;marijuana use;Measures;Mentors;Mentorship;Metabolic;mid-career faculty;minority stress;minority stressor;Modeling;molecular marker;Molecular Profiling;next generation;non-heterosexual;nonbinary;Outcome;Ovariectomy;Participant;patient oriented;Persons;Phenotype;phenotypic biomarker;physical conditioning;Progesterone;programs;Proxy;Psychiatry;Reproducibility;Research;Research Personnel;research study;Resources;response;Risk;Safety;Sampling;San Francisco;sex;sex assigned;Sexual and Gender Minorities;sexual minority men;skills;social stigma;Stress;stressor;Structure;substance use;substance use treatment;Surveys;systematic review;Testing;Testosterone;Training;Training Programs;transgender;United States;United States National Institutes of Health;Universities;Variant;Work

PROJECT_TITLE: Mentoring the next generation of substance use, HIV, and epigenetic researchers in sexual and gender minority health

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Data Science;Rural Health

PI_NAMEs: CURTIS, REAGAN  (contact)

PROJECT_TERMS: Accountability;Achievement;Address;Automobile Driving;Award;Budgets;Case Study;central database;Clinical;Clinical Sciences;community engagement;Computer software;Consultations;Coupled;Creativeness;Critical Thinking;Data;Data Analyses;Data Collection;data integration;data modeling;data portal;Data Science;data science resource;data visualization;Decision Making;Diffusion;Educational workshop;empowerment;Evaluation;experience;Focus Groups;follow-up;Funding;Goals;Health;health care settings;Health Personnel;Healthcare;Human Resources;improved;Individual;Infrastructure;innovation;Institution;Interview;Knowledge;Leadership;Link;meetings;Modeling;Online Systems;Outcome;Pathway Analysis;Patients;Performance;portability;Positioning Attribute;Process;Productivity;Progress Reports;Publications;Recommendation;Recurrence;Research;Research Personnel;Resource Allocation;Resources;Rural;Rural Health;rural healthcare;service delivery;Services;Site;Social Network;Surveys;System;Time;tool;Training;Translating;Translational Research;translational scientist;transmission process;user-friendly;West Virginia;Work

PROJECT_TITLE: Tracking and Evaluation Core


NIH_SPENDING_CATS: Cancer;Prevention

PI_NAMEs: JENSEN, ROY A. (contact)

PROJECT_TERMS: Address;Advocacy;Advocate;anti-cancer research;anti-cancer therapeutic;Area;Awareness;Basic Science;Behavior Therapy;Cancer Burden;Cancer Center;Cancer Center Support Grant;Cancer Control;cancer prevention;cancer research center director;Catchment Area;Clinic;Clinical;clinical care;Clinical Research;Collaborations;Communication;Communities;Development;Diagnosis;Discipline;Doctor of Pharmacy;Doctor of Philosophy;drug development;drug discovery;Education;Elements;Ensure;Environment;Evaluation;experience;Fostering;Future;Goals;Grant;health equity;Health system;improved;Incidence;innovation;Institution;Kansas;Knowledge;Laboratories;Lead;Leadership;Malignant Neoplasms;member;Morbidity - disease rate;mortality;multidisciplinary;next generation;novel therapeutics;Outcome;Persons;Play;population health;precision medicine;Prevention;Process;programs;Published Comment;Quality of life;Research;Research Infrastructure;Research Personnel;Resource Sharing;Resources;Role;Science;Scientist;Strategic Planning;success;survivorship;Technology;Therapeutic;Therapeutic Agents;therapeutic development;Training;Training and Education;Translational Research;Universities;Update;Vision;Visit;Work

PROJECT_TITLE: Leadership, Planning & Evaluation


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Rural Health;Social Determinants of Health

PI_NAMEs: GIBSON, LAURA F. (contact)

PROJECT_TERMS: 2019-nCoV;Acute;Address;Air Pollutants;Air Pollution;Appalachian Region;Area;Basic Science;Biological Assay;Clinical;clinical application;Clinical Investigator;Clinical Sciences;Collaborations;Collection;Communities;community engagement;Containment;COVID-19 pandemic;design;Development;Diabetes Mellitus;diagnostic assay;Diffusion;Disease;Drug Targeting;Education;Elderly;Emerging Communicable Diseases;Equipment;Exposure to;flexibility;Funding;Future;Future Generations;Gases;Goals;Health;health disparity;Health Priorities;Health Sciences;high throughput screening;Human Resources;hydraulic fracturing;Immunology;improved;Individual;Industry;Infrastructure;Inhalation;Inhalation Exposure;Inhalation Toxicology;innovation;Institution;interest;Investigation;Investments;Laboratories;Lead;Malignant Neoplasms;Mining;Modeling;Molecular;Molecular Analysis;Molecular Medicine;Morbidity - disease rate;mortality;National Institute of General Medical Sciences;novel;occupational health/safety;Outcome;Outcome Measure;pathogen;Persons;pollutant;population health;Positioning Attribute;Pre-Clinical Model;programs;Proteins;Public Health;Research;Research Design;Research Infrastructure;Research Personnel;Research Support;Resources;Rural Community;Rural Health;SARS-CoV-2 infection;Study models;Technology;Time;Toxic effect;toxicant;Training;Translational Research;translational scientist;Translations;United States Dept. of Health and Human Services;Universities;vaccine development;virology;West Virginia

PROJECT_TITLE: Technologies and Resources for Core Laboratories


NIH_SPENDING_CATS: Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Rural Health

PI_NAMEs: GODWIN, ANDREW K. (contact)

PROJECT_TERMS: anti-cancer research;Appointment;Area;Basic Science;Behavior Therapy;Cancer Center;Cancer Center Support Grant;Catchment Area;Clinical;Clinical Research;Clinical Sciences;Clinical Trials;Data;Development;Doctor of Philosophy;drug development;drug discovery;early phase clinical trial;Environment;Faculty;Faculty Recruitment;flexibility;Funding;Funding Mechanisms;Goals;Grant;improved;Incidence;Individual;innovation;Institution;interdisciplinary approach;International;Intervention;Investments;Kansas;Leadership;Malignant Neoplasms;Mentors;Mind;Minority Groups;Morbidity - disease rate;mortality;outreach;Patient-Focused Outcomes;Pilot Projects;Population Research;Population Sciences;Positioning Attribute;precision medicine;programs;recruit;Research;Research Activity;research faculty;Research Personnel;Research Project Grants;Research Proposals;Resource Sharing;Rural Population;Scientist;Special Population;Testing;Therapeutic;Translational Research;Underrepresented Minority;Underrepresented Populations;Universities;Vision

PROJECT_TITLE: Developmental Funds Core


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Rural Health;Social Determinants of Health

PI_NAMEs: FEINBERG, JUDITH  (contact)

PROJECT_TERMS: Academy;Achievement;Address;Affect;Agreement;Area;certificate program;Chronic lung disease;Clinical;Clinical Research;Clinical Sciences;clinical trial implementation;Clinical Trials;Clinical Trials Unit;Collaborations;community engagement;Core Facility;Development;Discipline;Enrollment;Ensure;experience;foot;Funding;Geography;Goals;Health;health disparity;Heart Diseases;Huntington Disease;improved;Infrastructure;Laboratories;Lead;Malignant Neoplasms;Medical center;meetings;Mentors;next generation;Participant;participant safety;Performance;performance site;Persons;Principal Investigator;Qualifying;remediation;Research;research facility;Research Personnel;Research Training;Resolution;Resources;Rural;rural Americans;rural dwellers;Rural Population;SARS-CoV-2 infection;School Nursing;Site;skills;Standardization;Stroke;success;telehealth;Translational Research;trial enrollment;United States Department of Veterans Affairs;United States National Institutes of Health;Universities;urban area;West Virginia

PROJECT_TITLE: Clinical Research Resources and Facilities Core


PI_NAMEs: MAYO, MATTHEW S (contact)

PROJECT_TERMS: Address;Advocacy;Advocate;anti-cancer research;anti-cancer therapeutic;base;Basic Science;Behavior Therapy;Biometry;Cancer Biology;Cancer Burden;Cancer Center;Cancer Center Support Grant;Cancer Control;cancer prevention;cancer therapy;Catchment Area;Clinic;clinical care;Clinical Pharmacology;Collaborations;Communities;Contracts;cost effective;Development;Diagnosis;drug development;drug discovery;Education;Ensure;Environment;Feedback;Flow Cytometry;Focus Groups;Fostering;Funding;Future;Gene Targeting;Goals;Grant;Guidelines;health equity;Image;improved;Incidence;Individual;Industry;Informatics;innovation;Institution;institutional financing;Investigational Therapies;Investments;Kansas;Knowledge;Laboratories;Lead;Leadership;Malignant Neoplasms;meetings;member;Microscopy;Monitor;Morbidity - disease rate;mortality;multidisciplinary;next generation;novel therapeutics;nutrition;Outcome;outreach;Peer Review;Peer Review Grants;Persons;Play;precision medicine;Prevention;Process;programs;Quality of life;Research;Research Personnel;Research Project Grants;Resource Sharing;Resources;Role;satisfaction;Science;Services;Solid;Strategic Planning;Surveys;survivorship;System;Technology;Therapeutic;Therapeutic Agents;therapeutic development;Training;Training and Education;Transgenic Organisms;United States National Institutes of Health;Universities;Vision

PROJECT_TITLE: Shared Resources Management


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Mental Health;Social Determinants of Health;Violence Against Women;Violence Research;Women's Health Research

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE A landmark report from the National Academies of Sciences, Medicine, and Engineering demonstrated the high prevalence of sexual harassment in medicine and science, which they conclude leads to a costly loss of talent. In a cohort of NIH T32 training programs, we will test whether a multi-modal virtual intervention with video game elements, developed from the NASEM conceptual model of sexual harassment, will increase Principal Investigators’ and mentors’ confidence in their ability to intervene and improve the culture and climate of the learning environment for NIH T32 funded mentees. We will also test whether the intervention improves civility, decreases rates of microaggressions and sexual harassment, and leads to a greater sense of belonging, well-being, research productivity, and persistence in a biomedical research career among NIH T32 mentees.

PI_NAMEs: SALLES, ARGHAVAN  (contact)

PROGRAM_OFFICER_NAME: NELSON, SHAKIRA M

PROJECT_TERMS: Address;Affect;Attention;Attitude;Awareness;Behavior;Biological Sciences;Biomedical Research;career;Categories;Climate;cohort;cost;Data;Department chair;Disparity;Doctor's Degree;Education;educational atmosphere;Educational Curriculum;Educational Intervention;Effectiveness;Elements;Enabling Factors;Engineering;Enrollment;Environment;equal employment opportunity;Ethnic Population;Evaluation;expectation;experience;Extramural Activities;Face;Faculty;follow-up;Funding;Gender;gender diversity;graduate student;Grant;harassment;health care settings;Hearing;High Prevalence;Hostility;Iceberg;improved;Intervention;Knowledge;lonely individuals;male;maltreatment;medical schools;Medical Students;Medicine;member;men;Mentors;Metaphor;microaggression;Minority-Serving Institution;Modeling;multimodality;non-verbal;Perception;Personal Satisfaction;Prevalence;prevent;Principal Investigator;Productivity;programs;Publishing;racial population;Randomized;Randomized, Controlled Trials;Recommendation;recruit;Reporting;Research;Research Support;responsible research conduct;Role playing therapy;Sampling;Science;Sexual and Gender Minorities;sexual coercion;Sexual Harassment;social;Stereotyping;Surgeon;Talents;Testing;Training;Training Programs;unconscious bias;United States National Academy of Sciences;United States National Institutes of Health;verbal;Video Games;virtual;virtual intervention;virtual platform;Water;Woman;women faculty;Work;Workplace

PROJECT_TITLE: Sexual harassment Training Of Principal investigators (STOP)


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Patient Safety;Rural Health

PI_NAMEs: LIN, TARA  (contact)

PROJECT_TERMS: Achievement;Award;Cancer Center;cancer clinical trial;Catchment Area;Clinic;Clinical Data;Clinical Protocols;Clinical Research;Clinical Treatment;Clinical Trials;Collaborations;Communities;Correlative Study;Data;data integrity;data management;Dedications;Development;Disease;early phase clinical trial;Enrollment;Ensure;Failure;Grant;Growth;implementation process;Individual;Infrastructure;innovation;Intervention;investigator training;investigator-initiated trial;Kansas;Life Cycle Stages;life span;Location;Malignant Neoplasms;Manuscripts;member;Minority;Missouri;Monitor;operation;outreach;Patients;Physician Executives;Process;process optimization;programs;Protocol Compliance;Protocols documentation;Publications;Real-Time Systems;Reporting;Research;Research Activity;Research Personnel;Research Priority;Resources;Rural Population;Safety;Science;Services;Site;Time;timeline;Training and Education;Translational Research;Translations;Underserved Population;Universities;Woman;working group

PROJECT_TITLE: Clinical Protocol and Data Management


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Machine Learning and Artificial Intelligence;Neurodegenerative;Neurosciences;Patient Safety;Precision Medicine;Prevention;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_DEPT: ANESTHESIOLOGY

PHR: PROJECT NARRATIVE Perioperative neurocognitive disorders (PNCD) affect about a quarter of geriatric surgical patients and increases the risk that those patients will go on to develop dementias such as Alzheimer's disease. However, no interventions exist to prevent PNCD, mostly because the etiology is unclear. We propose to build the foundation for a precision medicine approach for geriatric surgical patients who require surgery with anesthesia – this includes construction of a novel comprehensive database and an analysis platform capable of mining this multidimensional dataset.

PI_NAMEs: DROVER, DAVID RAYMOND (contact)

PROGRAM_OFFICER_NAME: ROBERTS, LUCI

PROJECT_TERMS: Acute;Address;Affect;Aging;Alzheimer's Disease;Anesthesia procedures;Appointment;Attention;Attenuated;Biological;Biological Markers;Blinded;Blood Banks;Blood specimen;Brain;Caring;Characteristics;Chronic;Clinical;Clinical Data;Clinical Research;Cluster Analysis;Cognitive;cognitive ability;cognitive testing;Collaborations;Communities;Cytometry;Data;data analysis pipeline;Data Analytics;Data Collection;Databases;Delirium;Dementia;Demographic Factors;Development;Dimensions;Disparate;Elasticity;Elderly;Electroencephalography;Electronic Health Record;Electrophysiology (science);Etiology;executive function;feasibility testing;feature selection;follow-up;Foundations;Health;human old age (65+);Immune;Immune response;Impaired cognition;improved;Incidence;Individual;Inflammatory;Inflammatory Response;Infrastructure;innovation;Interdisciplinary Study;interest;Intervention;Knowledge;large scale data;Lead;Length of Stay;Longterm Follow-up;Machine Learning;Measurement;Measures;Memory;Mining;Modeling;Morbidity - disease rate;mortality;multidimensional data;multidisciplinary;neurocognitive disorder;Neuropsychological Tests;novel;novel strategies;Operative Surgical Procedures;Outcome;participant enrollment;Pathology;patient population;patient stratification;Patients;Perioperative;Persons;Phase;Physiological;Postoperative Period;precision medicine;Precision Medicine Initiative;Predictive Factor;predictive modeling;prevent;Process;Quality of life;Questionnaires;Research;Research Project Grants;research study;response;Risk;Risk Assessment;Risk Factors;Risk Marker;risk prediction;risk stratification;Sentinel;Source;Speed;Standardization;stem;Structure;Subgroup;targeted treatment;Test Result;Testing;Therapeutic Intervention;Time;tool;verbal

PROJECT_TITLE: Building a Platform for Precision Anesthesia for the Geriatric Surgical Patient

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Behavior and Social Science of Aging Study Section[NIA-S]


NIH_SPENDING_CATS: Cancer;Patient Safety

PI_NAMEs: KHAN, QAMAR J. (contact)

PROJECT_TERMS: Area;Behavior Therapy;Biometry;Cancer Biology;Cancer Center;Cancer Center Support Grant;Cancer Control;cancer prevention;Catchment Area;Clinical Research;Clinical Trials;Collection;Communication;Data;Development;Disease;Doctor of Philosophy;drug discovery;Ensure;Evaluation;expectation;feasibility trial;Funding;Goals;Guidelines;improved;Institution;Institutional Review Boards;Intervention Trial;Investigational Therapies;Kansas;life span;Malignant Neoplasms;meetings;member;Monitor;Nature;novel;patient population;patient safety;Patients;Peer Review;probation;Process;Productivity;programs;Protocols documentation;Publications;Reporting;Research;Research Personnel;Research Priority;Resources;Review Committee;Safety;Statistical Data Interpretation;System;treatment trial;trial design;Universities;working group

PROJECT_TITLE: Protocol Review and Monitoring System


NIH_SPENDING_CATS: Biotechnology;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

PROJECT_TERMS: anti-cancer research;Antibodies;Area;Ascites;bench to bedside;Biological Specimen Banks;Biometry;Blood;Blood specimen;Body Fluids;Bone Marrow;Budgets;Cancer Center;Cancer Center Support Grant;cancer therapy;Child;Childhood;Cities;Clinical;Clinical Cancer Center;Clinical Data;clinical database;Clinical Protocols;Clinical Research;Clinical Trials;Collaborations;Collection;Communities;companion diagnostics;Computerized Medical Record;Consent;Contracts;Custom;Data;Data Set;Databases;Development;Diagnosis;Diagnostic;digital;digital imaging;Eligibility Determination;Enrollment;Ethics;Evaluation;Family Cancer History;Fees;Freezing;Funding;Future;Gene Expression Profiling;Grant;graphical user interface;Health;Health system;Histology;Histopathology;Hospitals;Human;Human Resources;imaging platform;Immunohistochemistry;Individual;informatics shared resource;Informed Consent;Institution;Institutional Review Boards;Intervention;Intuition;investigator-initiated translational research;investigator-initiated trial;Kansas;Laboratories;Latino;lifestyle factors;Liquid substance;Location;Malignant Neoplasms;Medical center;member;metropolitan;Minority Groups;Mission;Molecular;Morphology;nano-string;National Institute of General Medical Sciences;Outcome;Paper;Participant;Pathologic;Pathologist;Pathology;Patients;Play;Population;Prevention;Procedures;Process;programs;Property;protein expression;Provider;Publications;Reporting;repository;Research;Research Activity;Research Personnel;research study;Research Support;Resource Sharing;Resources;Role;safety net;Saliva;saliva sample;sample collection;Sampling;Services;Site;Slide;Specimen;Stains;System;The Cancer Genome Atlas;Tissue Microarray;Tissue Sample;Tissues;Translational Research;translational scientist;tumor registry;Tumor Tissue;Underrepresented Minority;Underserved Population;United States National Institutes of Health;Universities;Urine

PROJECT_TITLE: Biospecimen Shared Resource


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Digestive Diseases;Genetics;Human Genome;Pancreatic Cancer;Rare Diseases

ORG_CITY: HACKENSACK

ORG_NAME: HACKENSACK UNIVERSITY MEDICAL CENTER

PHR: PROJECT NARRATIVE This proposal is dedicated to novel experimental and sequencing strategies to quantify pancreatic cancer evo- lution, one aspect at a time. This approach has high potential for clinical relevance because the strategy seeks to resolve individual factors that drive the aggressive evolution of pancreatic cancer. Quantitatively defining these influences will significantly improve efforts to intervene and circumvent this typically lethal cancer.

PI_NAMEs: MAKOHON-MOORE, ALVIN  (contact)

PROGRAM_OFFICER_NAME: AULT, GRACE S

PROJECT_TERMS: Adaptive Behaviors;Automobile Driving;Autopsy;Award;Biological Assay;Breast;cancer cell;cancer genetics;Cancer Patient;career;cell motility;Cells;clinically relevant;Clonal Evolution;Colorectal;computerized tools;Dedications;deprivation;Development;Disease;Disseminated Malignant Neoplasm;DNA sequencing;Dysplasia;Endometrial;Epigenetic Process;Event;Evolution;Exhibits;experimental study;fitness;Gene Mutation;Genetic Heterogeneity;Genetic Transcription;genetic variant;Glucose;glucose metabolism;Glutamine;Growth;Heterogeneity;Histologic;Human;human tissue;improved;Individual;interest;Island;Knowledge;Lesion;Lung;Malignant neoplasm of lung;Malignant neoplasm of pancreas;Malignant neoplasm of prostate;Malignant Neoplasms;Melanoma;Mentors;Mentorship;Metabolic;metabolomics;migration;multimodality;Nature;Neoplasm Metastasis;Neoplasms;novel;novel strategies;Nutrient;Nutrient availability;Operative Surgical Procedures;Organ;Pancreas;pancreatic cancer cells;pancreatic cancer patients;Pancreatic duct;pancreatic neoplasm;Pathology;patient derived xenograft model;Patients;Pattern;Phylogenetic Analysis;Primary Neoplasm;Process;programs;Publications;Reproducibility;Research;Resected;Resolution;Resources;sample collection;Sampling;Science;Scientist;Shapes;single cell sequencing;single-cell RNA sequencing;Site;skills;Somatic Mutation;System;Technical Expertise;Time;Tissues;Training;treatment and outcome;tumor;Validation;Work

PROJECT_TITLE: Experimental evolution of pancreatic cancer

STUDY_SECTION_NAME: Transition to Independence Study Section (I)[NCI-I]


NIH_SPENDING_CATS: Neurosciences;Nutrition

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Project Narrative The human body contains metabolic microenvironments, such as the bone marrow and brain, that are low in nutrients and oxygen. Eukaryotic cells must adapt to limited nutrients to proliferate and survive in these environments. We will determine the metabolic pathways prioritized by cells in nutrient-poor and hypoxic metabolic milieus using novel techniques of our own design.

PI_NAMEs: PACOLD, MICHAEL EDWARD (contact)

PROGRAM_OFFICER_NAME: BARSKI, OLEG

PROJECT_TERMS: Acute;Amino Acids;Antioxidants;Autoimmune Diseases;Bone Marrow;Brain;Carbon;cell growth;Cell Respiration;Cell Survival;Cells;Chronic;Coenzyme Q10;Coenzymes;cofactor;Critical Pathways;design;Dioxygenases;Disease;Environment;Enzymes;Epigenetic Process;Eukaryotic Cell;extracellular;Gases;Glycine;Growth;Heart Diseases;Homeostasis;Human body;Hypoxia;Intercellular Fluid;Isotope Labeling;Laboratories;Malignant Neoplasms;Metabolic;Metabolic Pathway;Metabolism;Metastatic malignant neoplasm to brain;Neurotransmitters;Nitrogen;novel;Nucleotides;Nutrient;Nutrient availability;Nutrient Depletion;Nutritional Requirements;Organism;Oxygen;Pathogenesis;Pathway interactions;Physiological;prevent;Proliferating;Proteins;Serine;small molecule inhibitor;Source;Techniques;Therapeutic;Time

PROJECT_TITLE: Cellular Adaptations to Nutrient-Limited Metabolic Microenvironments

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-M(55)R]


NIH_SPENDING_CATS: Biotechnology;Cancer;Data Science

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

PI_NAMEs: GAJEWSKI, BYRON J. (contact)

PROJECT_TERMS: Address;Animals;anti-cancer research;Applications Grants;Area;Basic Science;Bioinformatics;Biometry;Budgets;Cancer Biology;Cancer Center;Cancer Center Support Grant;Cancer Control;cancer prevention;Clinical;Clinical Research;Clinical Trials;Collaborations;complex data;Computer Analysis;Computer software;cost effective;cost effectiveness;Custom;Data;Data Analyses;data cleaning;Data Collection;data management;Data Reporting;Data Science;Data Set;Databases;design;Development;Doctor of Philosophy;drug discovery;Education;Educational workshop;electronic data;Experimental Designs;Faculty;Frequencies;Funding;Genetic;Genomics;Goals;Grant;high dimensionality;Human;improved;Informatics;informatics shared resource;Information Systems;interest;Investigational Therapies;Investments;Kansas;Leadership;Maintenance;Malignant Neoplasms;member;Methodology;Methods;Molecular;novel;Outcome;Play;Postdoctoral Fellow;pre-clinical;programs;Quality Control;Reproducibility;Research;Research Activity;Research Design;Research Personnel;Research Project Grants;research study;Research Support;Resource Informatics;Resource Sharing;Resources;Role;Services;skills;Standardization;Statistical Data Interpretation;statistics;Students;synergism;System;Technology;tool;Training;Translational Research;trend;Universities;Visualization;Work

PROJECT_TITLE: Biostatistics & Informatics Shared Resource