ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Chronic Pain;Clinical Research;Drug Abuse (NIDA only);Mental Health;Opioid Misuse and Addiction;Opioids;Pain Research;Prescription Drug Misuse;Prevention;Substance Misuse

ORG_CITY: BALTIMORE

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: PROJECT NARRATIVE  In the current proposal, I devised a mixed-methods study to expedite the development of interventions addressing the negative consequences of opioid or cannabis use among patients with chronic pain. This project involves advanced secondary quantitative analyses of real-time smartphone-based ecological momentary assessment data from my primary sponsor’s NIDA R21 (DA048175; PI: Thrul), followed by an original semi-structured interview-based qualitative study of local expert substance use clinicians working with patients with chronic pain who use cannabis and opioids for their analgesic properties. This proposed project establishes a foundation for developing interventions for patients with chronic pain at risk of consequences from their cannabis or opioid use.

PI_NAMEs: STONE, BRYANT MICHAEL (contact)

PROGRAM_OFFICER_NAME: SU, SHELLEY

PROJECT_TERMS: Address;adverse outcome;Affect;Affective;Analgesics;anxious;Arousal;Cannabinoids;Cannabis;Cellular Phone;chronic pain;chronic pain management;chronic pain patient;Clinical;Clinical Trials;Cognitive;Cross-Sectional Studies;Data;Data Analyses;Depressed mood;design;Development;Diabetes Mellitus;Ecological momentary assessment;Effectiveness;emotion regulation;Emotional;epidemiology study;Exhibits;Family;Foundations;Fright;Funding;Future;General Population;Goals;Growth;Guidelines;Health;Heart Diseases;Heroin;Incidence;Individual;informant;information organization;insight;Intervention;Intervention Studies;Interview;Investigation;Legal;Literature;longitudinal design;Longitudinal Studies;Malignant Neoplasms;marijuana use;Mediating;Mediator;Medical;Mental Processes;Mentors;Methods;Modeling;Moods;National Institute of Drug Abuse;non-opioid analgesic;novel;Opioid;opioid epidemic;opioid use;opioid use disorder;Outcome;Outcome Study;overdose death;Pain;Pain management;Patients;Pattern;peer;Placebos;prescription opioid;prescription opioid misuse;Prevalence;Prevention strategy;Property;protective factors;Psychophysiology;Public Health;Recreation;Research;research and development;response;Risk;Risk Factors;risk mitigation;rumination;Sampling;Societies;stem;Structure;Substance Addiction;substance use;Surveys;synthetic opioid;Testing;therapy development;Time;trend;United States;Variant;Work

PROJECT_TITLE: Exploring Reactivity Among Patients with Chronic Pain Using Cannabis and Opioids: Mixed-Method Evidence of Promising Intervention Strategies

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F16-T (20)]


ADMINISTERING_IC: HL

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Lung;Pulmonary Hypertension

ORG_CITY: ALBUQUERQUE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR

ORG_STATE: NM

PHR: PROJECT NARRATIVE Pulmonary hypertension (PH) due to chronic lung disease and/or conditions causing hypoxia is a major cause of mortality and morbidity in the United States. With these diseases, enhanced pulmonary arterial constriction and remodeling cause increased resistance that leads to right heart failure and mortality in humans. The proposed studies are relevant to the mission of the National Heart, Lung, and Blood Institute because they will mechanistically examine the novel role of a molecular chaperone in an ion channel signaling cascade, which is required for the development of PH, thereby providing potential therapeutic targets to enhance the quality of life and prevent death in patients with these diseases.

PI_NAMEs: TUINEAU, MEGAN  (contact)

PROGRAM_OFFICER_NAME: SUTLIFF, ROY L

PROJECT_TERMS: Address;Agonist;antagonist;Apoptosis;Arteries;ASIC channel;Binding;Blood Vessels;CASP3 gene;Caspase;Cations;Cell Death;Cell membrane;Cell Physiology;Cessation of life;Chronic;Chronic lung disease;Communication;Complex;constriction;Data;Development;Disease;Endoplasmic Reticulum;Etiology;Fellowship;Functional disorder;Gene Expression;Genetic;Human;Hypoxia;hypoxia-induced pulmonary hypertension;improved;Ion Channel;Knockout Mice;Laboratories;lentivirally transduced;Lung;Membrane Potentials;Methods;Mission;Mitochondria;mitochondrial dysfunction;mitochondrial membrane;Molecular Chaperones;Molecular Target;Morbidity - disease rate;mortality;Mus;Muscle Mitochondria;National Heart, Lung, and Blood Institute;Neurons;new therapeutic target;novel;Pathogenicity;Pathway interactions;Patients;pharmacologic;Physiological;Physiology;Plasma Enhancement;Postdoctoral Fellow;prevent;protein expression;Proteins;Protons;pulmonary arterial pressure;Pulmonary arterial remodeling;Pulmonary Hypertension;Quality of life;Rattus;Research;Resistance;right ventricular failure;Rodent;Rodent Model;Role;sigma-1 receptor;Signal Transduction;skills;Smooth Muscle;Smooth Muscle Myocytes;Specificity;Tamoxifen;Testing;therapeutic target;Thinking;trafficking;Training;Transcript;treatment effect;United States;verbal;World Health Organization;Writing

PROJECT_TITLE: The Role of Mitochondrial Acid-Sensing Ion Channel 1 in Pulmonary Hypertension

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F10A-R (08)]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Breast Cancer;Cancer;Immunotherapy;Women's Health Research

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: PROJECT NARRATIVE The dysfunctional tumor vasculature worsens disease by preventing drug delivery and promoting metastasis and immune evasion. I propose to identify mechanisms of tumor vascular dysfunction and determine how an FDA- approved cell cycle inhibitor used to treat breast cancer affects tumor endothelial cells, which is currently not known. We hypothesize that cell cycle inhibition will normalize the tumor vasculature, expanding its therapeutic use to other cancer types and other prevalent diseases characterized by pathological angiogenesis.

PI_NAMEs: CAIN, SHELBY  (contact)

PROGRAM_OFFICER_NAME: ODEH, HANA M

PROJECT_TERMS: adduct;advanced breast cancer;Affect;Aftercare;angiogenesis;Angiogenic Factor;Antineoplastic Agents;Area;Biological Assay;Blood capillaries;Blood Vessels;Breast Cancer Treatment;Cadaverine;cancer cell;cancer type;CDK4 gene;Cell Cycle;Cell Cycle Arrest;Cell Cycle Inhibition;Cell Cycle Regulation;Cell Nucleus;Cell Proliferation;cell type;Cells;chemotherapy;comparison control;Confocal Microscopy;Contrast Media;Defect;density;Desmin;Development;Digestion;Disease;Drug Delivery Systems;Drug Modelings;Drug usage;EF5;Endothelial Cells;Endothelium;EO771;Exhibits;Fatty acid glycerol esters;FDA approved;Fluorescence-Activated Cell Sorting;G1 Arrest;Gene Expression;Genes;Hypoxia;Image;immune cell infiltrate;immune checkpoint blockade;Immune Evasion;Immunofluorescence Immunologic;Immunotherapy;Impairment;improved;inhibitor;intercellular communication;Light;Magnetic Resonance Imaging;malformation;Malignant Breast Neoplasm;Malignant Neoplasms;mammary;Mammary Neoplasms;Maps;Measures;Melanoma;Melanoma Tumor;Microscopy;molecular subtypes;Mus;Neoplasm Metastasis;Neoplasms in Vascular Tissue;neoplastic cell;novel strategies;Pathologic Neovascularization;PECAM1 gene;Perfusion;Permeability;pharmacologic;Population;prevent;Proteins;PTPRC gene;Resistance;response;Role;single-cell RNA sequencing;Skin;SOX17 gene;Specific qualifier value;Stains;Structure;Testing;Therapeutic;Therapeutic Uses;Time;Tissues;tomography;tumor;tumor hypoxia;tumor microenvironment;tumor progression;Tumor Promotion;Ubiquitination;Validation;Vascular Diseases;Venous

PROJECT_TITLE: Endothelial Cell Cycle Control to Normalize the Tumor Vasculature

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F09B-Z (20)]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Genetics;Human Genome;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: MINNEAPOLIS

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative Osteoclasts, the cells responsible for bone resorption, participate in craniofacial site-specific processes such as tooth eruption, orthodontic tooth movement, and skull modeling. Mandibular derived osteoclasts have been observed to have increased differentiation potential, as well as increased expression of key osteoclastogenic genes however no mechanism has been proposed for these observable differences. This proposal will work to identify potential genetic pathway differences between osteoclasts derived from the mandible and the femur bone marrow in a mouse model as well as work to better understand the involvement of these cells in mandibular bone healing which may aid in the future development of regenerative therapies for the craniofacial region.

PI_NAMEs: PHILLIPS, RACHEL BLEVINS (contact)

PROGRAM_OFFICER_NAME: FUQUA, CHANTEL FAYSAN

PROJECT_TERMS: Adult;Anatomy;ATAC-seq;bone cell;bone healing;Bone Injury;Bone Marrow;Bone Marrow Cells;Bone necrosis;Bone Regeneration;bone repair;Bone Resorption;Breeding;Cell Separation;Cells;Characteristics;Chromatin;clinical application;cortical bone;craniofacial;craniofacial bone;cranium;cytokine;Data;Development;differential expression;Disease;disease model;Embryo;experimental study;face bone structure;Femur;Future;Gene Expression;Generations;Genes;Genetic;Genetic Transcription;Goals;Growth;Head and neck structure;healing;Histology;Impairment;improved;Inflammatory;Injury;ITGAM gene;Jaw;knock-down;Knowledge;Learning;Literature;Location;long bone;Malignant Neoplasms;Mandible;Marrow;microCT;Minerals;Minnesota;Modeling;Molecular Profiling;monocyte;mouse model;Mus;Myelogenous;Myeloid Cells;Neoplasm Metastasis;Orthodontic;osteoclast progenitor;Osteoclasts;Osteomyelitis;Pathologic;Pathway interactions;Pharmaceutical Preparations;Physiological;Population;Process;Proliferating;Protocols documentation;Quantitative Reverse Transcriptase PCR;recruit;regenerative therapy;regenerative treatment;Regulation;repaired;Reporter;Research;RNA analysis;Role;School Dentistry;single cell sequencing;single-cell RNA sequencing;Site;skeletal;Skeletal bone;Skeleton;Small Interfering RNA;stem cell population;Techniques;Tissues;Tooth eruption;Tooth Movement;Training;transcriptome sequencing;transcriptomics;TREM2 gene;Universities;Work

PROJECT_TITLE: Characterization of mandible derived osteoclasts under physiological and bone healing conditions

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


NIH_SPENDING_CATS: Drug Abuse (NIDA only);Substance Misuse

ORG_CITY: CHAPEL HILL

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE The proposed project involves a fully integrated program of rigorous training and research in quantitative methods and dynamic theories of substance use. Through a simulation study and empirical data analysis of a high-value ecological momentary assessment dataset, I will examine the conditions under which DSEM and MLM perform optimally and test a novel edge-on, edge-off theory of substance use. Ultimately, the goal of the proposed fellowship is to provide guidance that allows substance use researchers to fully integrate their theories and hypotheses with complex methodological approaches.

PI_NAMEs: TRAVER, JENNIFER MARIE (contact)

PROGRAM_OFFICER_NAME: DEPADILLA, LARA MIREILLE

PROJECT_TERMS: addiction;Address;Affect;Applied Research;Back;Characteristics;Code;Complex;Data;Data Analyses;Data Analytics;Data Science;Data Set;data structure;design;Disadvantaged;Drug usage;Ecological momentary assessment;Ensure;Equation;Fellowship;flexibility;frontier;Funding;Future;Goals;Growth;Guidelines;Health;Hybrids;improved;innovation;interest;Joints;Link;Literature;Maximum Likelihood Estimate;Measurement;Methodology;Methods;model building;Modeling;multilevel analysis;National Institute of Drug Abuse;Nature;novel;Outcome;Parameter Estimation;Performance;Persons;Population;Process;programs;Property;Psychologist;Public Health;rapid growth;Recommendation;Reproducibility;Research;Research Personnel;Resources;Risk;Risk Assessment;Risk Behaviors;Sample Size;simulation;Smiling;Strategic Planning;substance use;Testing;theories;Time;time interval;Time Series Analysis;tool;Training;Validity of Results;Variant;virtual

PROJECT_TITLE: Modeling dynamic relations in substance use research: Challenges and opportunities.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F18-E (20)]


ADMINISTERING_IC: DK

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Hepatitis;Liver Disease;Neurosciences;Nutrition

ORG_CITY: IOWA CITY

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Project Narrative There are currently no approved pharmacological therapies for metabolic dysfunction-associated steatohepatitis (MASH). FGF21 and FGF21 analogs have shown tremendous pre-clinical and clinical efficacy for reversing MASH, at least partially by acting on the central nervous system (CNS). The proposed research seeks to determine the direct tissue targets of FGF21 that mediate the reversal of MASH and characterize how FGF21 action in the CNS affects liver metabolism.

PI_NAMEs: POTTHOFF, MATTHEW JOSEPH (contact)

PROGRAM_OFFICER_NAME: COOKE, BRAD

PROJECT_TERMS: Address;Affect;analog;Back;Biopsy;Body Weight;Brain;brain tract;Cell Death;cell type;Central Nervous System;Cholesterol;chronic liver disease;Cirrhosis;clinical efficacy;Data;Development;Diet;dietary;Disease;Disease Progression;Energy Metabolism;experimental study;Fatty acid glycerol esters;Fatty Liver;FDA approved;fibroblast growth factor 21;Fibroblast Growth Factor Receptors;Fibrosis;Functional disorder;Future;Genes;Genetic;Glutamates;Goals;Health;Hepatic;Hepatocyte;Homeostasis;improved;Incidence;Inflammation;innovation;Investigation;lipid metabolism;Lipids;Liver;Liver Cirrhosis;Liver diseases;Liver Failure;Liver Fibrosis;liver function;liver metabolism;Mediating;Metabolic;Metabolic Diseases;Metabolic dysfunction;Metabolism;Modeling;mouse model;Nerve;Neurons;Non-Insulin-Dependent Diabetes Mellitus;novel;Nucleus solitarius;Nutrient;Obesity;Obesity Epidemic;Pathologic;Pathology;Pathway interactions;Patients;Persons;pharmacologic;Pharmacologic Substance;Pharmacotherapy;Physiological;Population;Pre-Clinical Model;preclinical efficacy;Primary carcinoma of the liver cells;progression risk;Public Health;receptor;Regulation;Research;Research Proposals;Resolution;response;Risk;Rodent;Signal Transduction;simple steatosis;stable isotope;Steatohepatitis;Stress;Testing;Therapeutic;Tissues;tool;Tracer;Triglycerides;United States;Work

PROJECT_TITLE: Regulation of Metabolism by FGF21

STUDY_SECTION: POMD

STUDY_SECTION_NAME: Pathophysiology of Obesity and Metabolic Disease Study Section[POMD]


NIH_SPENDING_CATS: Asthma;Genetics;Health Effects of Indoor Air Pollution;Lung;Neurosciences

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: The research proposal addresses a critical issue in public health by investigating the molecular mechanisms underlying asthma, a chronic respiratory disease affecting over 339 million people globally. This study will focus on the role of muscarinic acetylcholine receptors in the airway epithelium (M1 and M3) and their involvement in asthmatic allergen uptake, inflammation, and remodeling of the lungs. Understanding the specific functions of each receptor subtype may lead to the development of targeted therapeutic options for the roughly 10% of asthma patients who do not respond well to standard treatments, potentially improving outcomes and reducing side effects on a significant scale.

PI_NAMEs: ZWICK, STEVEN MICHAEL (contact)

PROGRAM_OFFICER_NAME: LU, JINING

PROJECT_TERMS: Acetylcholine;Acute;Address;Adrenal Cortex Hormones;Affect;Affinity;Agonist;Air Movements;airway epithelium;Allergens;allergic response;Animal Experimentation;antagonist;Anti-Cholinergics;Antigen Presentation;Antigen-Presenting Cells;Antigens;Area;Asthma;asthma model;asthmatic;asthmatic airway;asthmatic patient;Binding;Biomedical Engineering;Cell Separation;cell type;Cells;Characteristics;chelation;cholinergic;Cholinergic Agents;Cholinergic Receptors;chronic respiratory disease;Clinical;Clinical Trials;clinically relevant;Communication;Communities;Complication;conditional knockout;constriction;Curiosities;cytokine;Data;Development;Disease;Drug usage;Environment;Enzyme-Linked Immunosorbent Assay;eosinophil;Eosinophilia;Epithelial Cells;Epithelium;extracellular;Face;Flow Cytometry;Funding;Genetic;Goals;Goblet Cells;House Dust Mite Allergens;Hypersensitivity;Image;Immune;Immunofluorescence Immunologic;Immunology;improved;improved outcome;Individual;Inflammation;Inflammation Mediators;Inflammatory;inflammatory marker;Inflammatory Response;Inhalation;Interleukin-13;Interleukin-4;Interleukin-5;Interleukin-9;Intestines;Kinetics;Knockout Mice;Label;Laboratories;Learning;Lung;Lung Diseases;Measures;Mediating;Mentorship;Metaplasia;Molecular;Molecular Target;mouse genetics;mouse model;Mucous body substance;Mus;Muscarinic Acetylcholine Receptor;Muscarinic M1 Receptor;Muscarinic M3 Receptor;new therapeutic target;Oral Ingestion;Output;Ovalbumin;Pathology;Persons;Pharmaceutical Preparations;Phenotype;Physiology;promoter;Public Health;Pulmonary Inflammation;Pyroglyphidae;Quality of life;receptor;receptor function;Reporting;Research Personnel;Research Proposals;respiratory smooth muscle;response;Role;Scientist;Secretory Cell;Secretory Rate;side effect;Signal Transduction;Site;skills;Smooth Muscle;standard care;Structure;success;Surface;Symptoms;targeted treatment;Technical Expertise;Techniques;Testing;Th2 Cells;Therapeutic;Therapeutic Uses;Trachea;Training;two photon microscopy;uptake;Visualization;Work

PROJECT_TITLE: Dissecting the functions of muscarinic receptor subtypes in the airway epithelium for asthmatic allergen uptake, inflammation, and remodeling


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: CHICAGO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative Patients with traumatic spinal cord injuries (SCI) risk irreversible functional decline if they do not undergo a timely program of supervised rehabilitation at an inpatient rehabilitation facility (IRF). However, recent work published by our group demonstrates that publicly-insured SCI patients are often not triaged to IRFs in comparison to privately-insured peers, even after controlling for risk factors such as age, comorbidities, and injury severity. The study here aims to quantify the economic costs and clinical complications associated with lack of IRF access and uses novel statistical and machine learning methods to predict the cost effectiveness of policy interventions for improving the care of this vulnerable population.

PI_NAMEs: RAO, SAIEESH ALAN (contact)

PROGRAM_OFFICER_NAME: CHANLONGBUTRA, AMORNRAT

PROJECT_TITLE: Long Term Outcomes and Cost-Implications of Inequitable Access to AcuteInpatient Rehabilitation

STUDY_SECTION: HCRT

STUDY_SECTION_NAME: Healthcare Research Training [HCRT]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Obesity

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Intellectual disability, characterized by an I.Q. less than 70 and significant impairments in intellectual and adaptive behaviors, affects approximately 1-3% of the world population. Despite the heterogeneous and genetically complex nature of this condition, recent studies have led to the discovery that many genes linked to intellectual disabilities are unified by common underlying molecular dysfunctions. In these proposed studies, I use the fruit fly Drosophila as a system to model a heritable form of intellectual disability, which allows me to explore the brain-metabolism connection in development and disease.

PI_NAMEs: GOLDY, JORDAN  (contact)

PROGRAM_OFFICER_NAME: MATTHEWS, MARGUERITE

PROJECT_TERMS: 3' Untranslated Regions;Adaptive Behaviors;Adipose tissue;Affect;Animals;autosome;axon guidance;Biochemical;Blood Glucose;Body fat;Brain;brain metabolism;career development;Catalytic Domain;Cell Survival;cell type;Cells;Central Nervous System;Communication;Complex;Coupled;Cysteine;Data;Deamination;Defect;Deposition;Development;Diagnosis;Disease;Distant;Drosophila genus;Drosophila melanogaster;experience;Fat Body;Fatty acid glycerol esters;fly;Functional disorder;Gene Expression;General Population;Genes;Genetic;Genetic Techniques;Goals;Hemolymph;Heritability;Histidine;Human;Hypertriglyceridemia;Impairment;Individual;Inherited;insight;Insulin;insulin signaling;insulin-like peptide;Intellectual functioning disability;Larva;Link;lipidomics;Lipids;Locomotion;Maps;Mediating;Memory;Mentors;Messenger RNA;Metabolic;Metabolic dysfunction;Metabolic Pathway;Metabolism;Methylation;Methyltransferase;Modeling;Modification;Molecular;mRNA Expression;mRNA Translation;mutant;Mutation;Nature;nervous system development;Neuroglia;Neurologic;Neuronal Dysfunction;neuronal metabolism;Neurons;novel;Nuclear Export;Nutritional;Obesity;obesity risk;Organ;Orthologous Gene;Pathway interactions;Patients;Pattern;peptide hormone;Peripheral;Phenotype;Physiological;PIK3CG gene;Play;polyadenosine;Polyadenylation;Population;posttranscriptional;Protein Family;Proteins;Regulation;Repression;Research;Risk;RNA;RNA Interference;RNA Processing;RNA Splicing;RNA-Binding Proteins;Role;Scientist;Site;Site-Directed Mutagenesis;System;Techniques;Testing;Tissues;Training;Transcript;transcriptome sequencing;Translations;Travel;Work;Zinc Fingers

PROJECT_TITLE: An Evolutionarily Conserved RNA Binding Protein Critical for Proper Neuronal Function Regulates Lipid Storage and Metabolic Pathways

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F03A-E (20)]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: HADLEY

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF MASSACHUSETTS AMHERST

PHR: Project Narrative Nature has evolved sophisticated mechanisms to ensure proteins fold into their functional forms and prevent accumulation of potentially toxic misfolded species. Many physiologically important proteins, including enzymes and antibodies, are secreted from the cell via the endoplasmic reticulum (ER). This project will determine the structural basis of quality control activity of the ER gatekeeper of secretory protein folding, UGGT, through studies of its interaction with protein clients and its co-chaperone, the 15-kDa selenoprotein (SEP15).

PI_NAMEs: WILLIAMS, ROBERT V (contact)

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TERMS: Adopted;Alzheimer's Disease;Amino Acids;analog;Analytical Chemistry;Antibodies;Binding;Biochemical Process;Biochemistry;Biological Assay;Biological Process;Biophysics;career;Cell Culture Techniques;Cell secretion;Cellular biology;Client;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Complex;crosslink;Disease;Disulfides;Endoplasmic Reticulum;Ensure;Enzymes;experimental study;Gatekeeping;Genes;Glucose;Glucosyltransferase;Glycoproteins;glycoproteomics;Hepatocyte;Hong Kong;Human;insight;Lectin;Mammalian Cell;mannosyl(9)-N-acetylglucosamine2;Mass Spectrum Analysis;Mediating;Methods;misfolded protein;Modeling;Molecular Chaperones;Molecular Conformation;Monitor;Nature;non-Native;Organism;Oxidation-Reduction;Oxidoreductase;Parkinson Disease;Pathway interactions;Physiological;Polysaccharides;prevent;Process;Productivity;protein folding;Proteins;Proteome;proteostasis;Quality Control;Research;risk mitigation;Role;secretory protein;Selenocysteine;selenoprotein;Signal Transduction;structural biology;Structure;Substrate Interaction;Techniques;Therapeutic;therapeutic development;Therapeutic Intervention;three dimensional structure;Training;Trypsin;TXN gene;Variant;Work

PROJECT_TITLE: Demystifying the interaction of UGGT, the ER folding gatekeeper, with its substrates and co-chaperone

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F04B-S (20)]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cannabinoid Research;Endocannabinoid System Research;Mental Health;Neurosciences;Social Determinants of Health

ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

ORG_STATE: CA

PHR: PROJECT NARRATIVE  Early life adversity is extremely common and is highly associated with a wide variety of neuropsychiatric disorders later in life. The proposed research will test the impact of a potential endocannabinoid therapy by targeting the underlying synaptic and behavioral dysfunction associated with early life adversity. Results from this study will reveal mechanisms of synaptic impairments caused by early life adversity and potential targets for intervention.

PI_NAMEs: DE CARVALHO, GREGORY  (contact)

PROGRAM_OFFICER_NAME: PINARD, COURTNEY ROSE

PROJECT_TERMS: addiction;Address;Adult;adverse childhood events;Adverse effects;Adverse event;Affect;antagonist;Anterior;Anxiety;Basic Science;Beds;Behavior;behavior influence;behavior test;Behavioral;behavioral response;Binding;Biochemistry;Biotin;Brain;Brain region;Cannulas;cell type;Cells;cingulate cortex;CNR1 gene;Cognition;Cognitive deficits;comparison control;Corpus striatum structure;Data;Dedications;density;Dependence;Development;Dorsal;early life adversity;Early treatment;Electrophysiology (science);Elements;Emotional;endocannabinoid signaling;Endocannabinoids;endogenous cannabinoid system;Ensure;Environment;Exhibits;Exposure to;Female;Functional disorder;Functional impairment;Gender;Genetic Transcription;Glutamates;Goals;Health;Human;Immunohistochemistry;Impairment;Infusion procedures;Intervention;late life;learned behavior;Life;Link;male;Measures;Mediating;Mental Depression;Mental disorders;Mentors;Messenger RNA;metabotropic glutamate receptor 5;Midbrain structure;Mission;Mus;N-Methylaspartate;National Institute of Mental Health;Neurons;neuropsychiatric disorder;neurotransmitter release;new therapeutic target;Operant Conditioning;optogenetics;patch clamp;Pilot Projects;Play;Population;postsynaptic;presynaptic;Prevention;Process;protein expression;Proteins;Publishing;Quality of life;Quantitative Reverse Transcriptase PCR;Rattus;Reporting;Research;Research Personnel;Risk Behaviors;risk mitigation;Rodent;Role;Sensory;sex;Signal Transduction;socioeconomics;Specificity;Stress;Stressful Event;Synapses;Synaptic Transmission;targeted treatment;Testing;Tissues;transmission process;traumatic event;United States;Western Blotting;Work

PROJECT_TITLE: The Impact of Early Life Adversity on mGluR5-driven Endocannabinoid Signaling and Behavioral Adaptability

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F01B-M (20)]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Clinical Research;Health Services;Networking and Information Technology R&D (NITRD);Nutrition;Obesity;Patient Safety;Prevention

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

PHR: Project Narrative Electronic health records (EHR) include rich data on large populations over long periods of time and are available at relatively low cost, but data in EHR are not collected for research purposes. Missing data is extremely common in EHR and analyses that exclude patients on the basis of incomplete data are subject to selection bias. The focus of this proposal is the development of statistical methods to adjust for selection bias due to missing data in EHR-based research, with a particular focus on settings where the incomplete data informs eligibility criteria for inclusion in the analysis population.

PI_NAMEs: BENZ, LUKE S (contact)

PROGRAM_OFFICER_NAME: DENSMORE, CHRISTINE L

PROJECT_TERMS: Address;Adoption;Adult;Adverse event;American;bariatric surgery;Body mass index;Body Weight decreased;Clinical;clinical database;clinical practice;Clinical Trials;clinically significant;cohort;Cohort Studies;Comparative Effectiveness Research;Complex;Computer software;Consumption;conventional therapy;cost;Data;Data Sources;Databases;design;Development;Diabetes Mellitus;EHR research;Electronic Health Record;Eligibility Determination;Event;Exclusion;experience;flexibility;Funding;Future;Guidelines;Health;Health system;Healthcare;Hyperglycemia;Individual;Infrastructure;interest;Kidney Diseases;Knowledge;Literature;Longitudinal Studies;machine learning method;macrovascular disease;Medical Research;Methodology;Methods;Mind;Modeling;Modernization;Morbid Obesity;Non-Insulin-Dependent Diabetes Mellitus;novel;obese patients;Obesity;Observational Study;Operative Surgical Procedures;Outcome;Paper;patient population;Patients;Persons;Population;Population Analysis;pre-doctoral;Prevalence;Probability;Procedures;Property;Public Health;Randomized;randomized, clinical trials;Research;Research Design;Research Personnel;Risk Factors;risk selection;Safety;Selection Bias;simulation;Site;skills;software development;Source;Specific qualifier value;Statistical Data Interpretation;Statistical Methods;study population;success;Time;tool;treatment planning;United States;United States National Institutes of Health;user-friendly;Weight;weight loss intervention;Work

PROJECT_TITLE: Adjusting for selection bias due to missing eligibility data in electronic health records-based observational studies

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Fellowships in Diabetes Endocrinology and Metabolic Diseases [DDK-E]


ADMINISTERING_IC: HD

ED_INST_TYPE: GRADUATE SCHOOLS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Mental Health;Neurosciences;Pediatric

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIV NEW YORK MORNINGSIDE

ORG_STATE: NY

PHR: PROJECT NARRATIVE  We seek to understand the precise neural oscillatory dynamics that support attention development, and their impact on memory representations over the first two years of life. We hypothesized that increases in phase- amplitude coupling between top-down (anterior, low-frequency) and bottom-up (posterior, high-frequency) oscillations would increase over infancy, increased coupling would lead to more consistent patterns of neural activity, and more consistent neural activity would lead to specific memory representations. These findings will mechanize the ways in which oscillatory dynamics, age, and experience interact to support early learning, and suggest that alongside ongoing development of brain regions typically attributed to specific memory, interactions with attention explain some early memory changes.

PI_NAMEs: FOREST, TESS  (contact)

PROGRAM_OFFICER_NAME: MILLER, BRETT

PROJECT_TITLE: Discovering how emerging oscillatory dynamics interact with attention to shape memory representations in infancy


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cannabinoid Research;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Drug Abuse (NIDA only);Mental Health;Neurosciences;Pain Research;Substance Misuse

ORG_DEPT: PSYCHIATRY

PHR: Project Narrative Despite millions of active prescriptions for medical cannabis in the United States, relatively little is known about impacts on behavior, neural function, and pharmacology. This project measures neurobehavioral function and drug exposure with an emphasis on learning, memory, and executive functions at two timepoints, pre- treatment and four months post-treatment initiation, in adult-onset medical cannabis users who are prescribed cannabis products for the treatment of chronic pain. Behavioral and neuroimaging findings, as well as assessments of efficacy, are expected to inform public health and policy-based initiatives regarding impacts of THC- versus CBD-dominant forms of cannabis in adult initiates who are otherwise cannabis naive.

PI_NAMEs: BIRNBAUM, ANGELA K;LUCIANA, MONICA  (contact)

PROGRAM_OFFICER_NAME: FEDOTA, JOHN RAPHAEL

PROJECT_TERMS: addiction;Adolescent and Young Adult;Adult;Advertisements;Aftercare;Age;age group;aged;Aging;alternative treatment;Behavior;Behavior assessment;Behavior Therapy;Behavioral;behavioral outcome;Blood;Brain;Brain imaging;Brain region;Brain scan;brain volume;Cannabinoids;Cannabis;Categories;chronic pain;chronic pain management;chronic pain patient;Clinical;Cognition;Cognitive;cognitive control;cognitive testing;Cohort Effect;Collaborations;comorbidity;connectome;Data;Data Set;demographics;Diagnosis;diaries;diffusion weighted;Dose;Drug Exposure;effective therapy;efficacy evaluation;Enrollment;Epilepsy;executive function;Exposure to;externalizing behavior;Formulation;Frequencies;Functional Magnetic Resonance Imaging;Goals;Health;Hippocampus;HIV;Hour;Human;Impaired cognition;Impairment;Impulsivity;Individual;Ingestion;innovation;interest;Interview;Learning;Legal;life span;Literature;Magnetic Resonance Imaging;marijuana use;marijuana user;Measures;Medical;Medical Marijuana;Memory;Mental Health;Methods;middle age;Minnesota;Modeling;MRI Scans;multimodality;neural;neurobehavioral;neuroimaging;Neurologic;Neurophysiology - biologic function;neuroprotection;Observational Study;older adult;Older Population;Opioid;opioid use;Outcome;Pain;pain patient;Paired-Associate Learning;Parents;Participant;Patients;Pattern;Personality Traits;Persons;Pharmaceutical Preparations;Pharmacology;Population;prescription opioid;Process;Public Health;public health research;Public Policy;Publishing;Qualifying;Recreation;recruit;Research;Resources;response;Rest;Risk;Sampling;Scanning;sex;sex as a biological variable;Structure;substance misuse;substance use;success;Telephone;Testing;THC concentration;Time;treatment adherence;United States;Universities;Visit;white matter;Work;young adult

PROJECT_TITLE: Neurobehavioral Impacts of Medical Cannabis Use: An Observational Study

STUDY_SECTION: ARM

STUDY_SECTION_NAME: Addiction Risks and Mechanisms Study Section[ARM]


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Genetics;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Radiation Oncology;Rare Diseases

ORG_NAME: DANA-FARBER CANCER INST

PHR: Project Narrative Diffuse midline gliomas (DMG) are the most common malignant brain tumors of children. Radiotherapy is the only treatment known to prolong patient survival but DMGs inevitably recur following radiotherapy and are uniformly fatal. The goal of the work proposed here is to build on our identification of conditional synthetic lethal vulnerabilities in DMGs to test a pair of drugs that have potential to greatly enhance the clinical benefit of radiotherapy for children with DMG.

PI_NAMEs: CHOWDHURY, DIPANJAN  (contact);HAAS-KOGAN, DAPHNE A.

PROGRAM_OFFICER_NAME: BUCHSBAUM, JEFFREY

PROJECT_TERMS: Agar;Amino Acid Substitution;Animals;antagonist;Architecture;Biopsy;Brain;cell transformation;Cells;Chemicals;chemotherapy;Child;Child Care;Childhood;Childhood Glioma;Chromans;Chromatin;Chromatin Structure;Clinical;clinical care;Clinical Research;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Combined Modality Therapy;Conduct Clinical Trials;CRISPR screen;Dana-Farber Cancer Institute;Daphne plant;Dependence;design;Diagnostic;diffuse midline glioma;DNA;DNA biosynthesis;DNA Damage;DNA Double Strand Break;DNA Polymerase Inhibitor;DNA Repair;DNA replication fork;DNA-Directed DNA Polymerase;Doctor of Medicine;Doctor of Philosophy;Drug Combinations;drug distribution;Equilibrium;Excision;experience;Gene Transfer;Genetic Suppression;Genetic Transcription;genome-wide;Goals;H3 K27M mutation;Histone H3;Immune;improved;inhibitor;International;Knock-out;Leadership;Malignant - descriptor;Malignant neoplasm of brain;Mass Spectrum Analysis;Measures;member;Molecular;molecular marker;Monitor;neuro-oncology;Nucleosomes;Oncogenic;Oncoproteins;Operative Surgical Procedures;patient derived xenograft model;patient response;Patients;Pediatric Neoplasm;Penetrance;personalized approach;Pharmaceutical Preparations;Phosphoproteins;Phosphotransferases;Polymerase;pre-clinical;predictive modeling;premature;progenitor;Radiation;Radiation Oncology;radiation response;Radiation therapy;Reaction Time;recruit;Recurrence;Relapse;repaired;replication stress;Research Personnel;Resources;response;Role;Scientist;skills;Specificity;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;spectroscopic imaging;standard of care;stem;Sum;synergism;Testing;Therapeutic;Time;treatment response;Work;Xenograft procedure

PROJECT_TITLE: Enhanced radiotherapy for pediatric glioma via synthetic lethal vulnerabilities

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


ADMINISTERING_IC: DC

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Clinical Research;Complementary and Integrative Health;Pediatric

ORG_CITY: RICHARDSON

ORG_NAME: UNIVERSITY OF TEXAS DALLAS

ORG_STATE: TX

PHR: Project Narrative Developmental language disorder (DLD) is highly prevalent, affecting over 7% of children and is associated with poor academic and mental health outcomes. While language deficits are the hallmark of this disorder, children with DLD show co-occurring deficits in other domains, including music. In the present project, linkages across language and music, specifically in the grouping of rhythmic sequences, will be assessed in children with DLD and their typical peers, with a long-term aim of developing new avenues for identification and treatment of DLD across the lifespan.

PI_NAMEs: KREIDLER, KATHRYN V (contact)

PROGRAM_OFFICER_NAME: SCHURMAN, JACLYN REBECCA

PROJECT_TERMS: 8 year old;Affect;Age;Area;Characteristics;Child;Child Support;Complex;design;Disease;Early identification;Elements;experimental study;foot;Genetic Transcription;Goals;Group Structure;Grouping;Hand;Impairment;Individual;Intervention;kinematics;Language;Language Development Disorders;Language Disorders;Learning;Learning Disorders;lexical;life span;Linguistics;Lip structure;Manuals;Maps;Measurement;Measures;Mental Health;Methodology;Motion;Motor;Movement;movement analysis;Music;Nature;novel;Oral cavity;Outcome;Pattern;peer;Performance;Periodicity;Phenotype;phrases;Process;Production;Property;Research;School-Age Population;Series;skills;Speech;Speech Sound;Structure;Testing;word learning;Work

PROJECT_TITLE: Rhythmic Grouping in Developmental Language Disorder

STUDY_SECTION_NAME: Special Emphasis Panel[ZDC1 SRB-N (35)]


NIH_SPENDING_CATS: Genetics;Neurosciences;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: FARMINGTON

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT

ORG_STATE: CT

PHR: NARRATIVE Modification of RNA can regulate neuronal development by altering RNA structure and, in the case of ribosomal RNA modifications, by altering translation patterns of the ribosome. This project will investigate the function of fibrillarin-like 1 (FBLL1) to regulate translation through neuronal differentiation as a neuron-specific ribosomal RNA methyltransferase. This may reveal a novel ribosome biogenesis pathway controlling developmental neuronal gene expression and functions.

PI_NAMEs: ALSHAWI, SARAH ANN (contact)

PROGRAM_OFFICER_NAME: STEIN, KATHRYN K

PROJECT_TERMS: Adult;Affect;Binding;Binding Proteins;Binding Sites;Biochemical;Biogenesis;Biological;Brain;Cell Nucleolus;Cell Physiology;cell type;Cells;Chemicals;Clustered Regularly Interspaced Short Palindromic Repeats;Co-Immunoprecipitations;Complex;Consensus Sequence;Data;Development;embryonic stem cell;Enzymes;fibrillarin;Gene Expression;gene function;Genes;Genetic;Goals;Heterogeneity;Human;knock-down;Knock-out;Link;Location;Mass Spectrum Analysis;Mediating;Messenger RNA;Methods;Methylation;Methyltransferase;Modeling;Modification;Molecular;Mouse Embryonic Stem Cells;nanopore;nerve stem cell;neurogenesis;neuron development;Neuronal Differentiation;Neurons;novel;Ontology;Outcome;overexpression;paralogous gene;Pattern;Phenotype;Pituitary Gland;pluripotency;programs;Proteins;Regulation;Ribosomal Biogenesis Pathway;Ribosomal RNA;ribosome profiling;Ribosomes;RNA;RNA Binding;RNA Recognition Motif;Role;S-Adenosylhomocysteine;S-Adenosylmethionine;Shapes;Site;Small Nucleolar Ribonucleoproteins;Small Nucleolar RNA;Specificity;stem cell biomarkers;stem cell differentiation;Stem cell pluripotency;stem cells;stemness;Structure;Testis;Tissues;Transcript;transcriptome;transcriptome sequencing;Translating;Translation Alteration;Translational Regulation;Translations;Variant;Work

PROJECT_TITLE: Elucidating the role of FBLL1 in ribosome function during neuronal differentiation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F08-L (20)]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Cancer;Clinical Research

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

PHR: This document is not required per guidelines for this supplement.  No PHR

PI_NAMEs: HERBST, ROY S (contact)

PROGRAM_OFFICER_NAME: MOONEY, MARGARET M

PROJECT_TERMS: American College of Radiology Imaging Network;Award;Biology;Cancer Hospital;Caring;Chemicals;clinical center;Connecticut;drug development;Eastern Cooperative Oncology Group;Epidermal Growth Factor Receptor;Faculty;Grant;Guidelines;hospital care;Infrastructure;Lead;Leadership;patient population;Phase;pilot trial;Program Development;programmed cell death protein 1;programs;Randomized;Recording of previous events;Research Personnel;Resistance;Rewards;Role;santin;Science;Signal Transduction;Solid;Southwest Oncology Group;Support Groups;Time;translational potential;Translational Research;Vision;Work;Yale Cancer Center

PROJECT_TITLE: Yale Cancer Center NCTN LAPS


NIH_SPENDING_CATS: Aging;Contraception/Reproduction;Genetics;Infertility;Maternal Health;Maternal Morbidity and Mortality;Women's Health Research

ORG_CITY: KANSAS CITY

ORG_NAME: STOWERS INSTITUTE FOR MEDICAL RESEARCH

ORG_STATE: MO

PHR: Project Narrative  An escalating number of women are postponing childbirth to their later reproductive years, leading to a rise in age-dependent fertility challenges and adverse pregnancy outcomes. Despite being a central factor in age-dependent fertility decline, the deterioration of oocyte quality remains insufficiently explored. This proposal aims to address this research gap by examining the age-dependent alterations in translation, a vital molecular process in oocyte development and maturation, that could serve as a potential pathway for future therapeutic advancements.

PI_NAMEs: GALLIGOS, ANNA  (contact)

PROGRAM_OFFICER_NAME: TAYMANS, SUSAN

PROJECT_TERMS: Address;advanced maternal age;adverse pregnancy outcome;Affect;Age;age related;age related changes;age related decline;Age Years;Aging;Area;Binding;Biogenesis;cell type;Cells;child bearing;Childbirth;Chromosome abnormality;Competence;Complement;Conceptions;Congenital Abnormality;Cytoplasm;Data Set;Delayed Childbearing;Deterioration;Development;DNA-Directed RNA Polymerase;Embryo;Embryonic Development;experience;experimental study;Female;female reproductive system;Fertility;fertility improvement;fertility preservation;Fetal health;Fetus;folliculogenesis;Fractionation;Frequencies;Future;Genome;Goals;Healthcare;Human;Immunofluorescence Immunologic;improved;In Vitro;in vivo;insight;Investigation;Lipids;Mammals;Maternal Health;maternal outcome;Measures;Menopause;Messenger RNA;Methylation;methylation pattern;Molecular;mouse model;Mus;new therapeutic target;novel;Nutritional Requirements;old mice;oocyte quality;Oocytes;Outcome;Ovary;Pathway interactions;Play;Polyribosomes;polysome profiling;Population;Pre-Eclampsia;Pregnancy;Premature Birth;Process;Production;Protein Biosynthesis;Proteins;Regulation;Reporter;reproductive;reproductive function;reproductive longevity;reproductive senescence;Reproductive Technology;Research;Ribosomal Biogenesis Pathway;Ribosomal DNA;Ribosomal RNA;Ribosomes;Risk;RNA;RNA chemical synthesis;Role;senescent cell;single-cell RNA sequencing;Societies;Source;Spontaneous abortion;System;Terminator Codon;Testing;Therapeutic;Time;Transcript;transcription factor;Transcriptional Regulation;translation assay;Translation Process;Translational Repression;Translations;Vesicle;Woman;Work

PROJECT_TITLE: Investigating ribosome biogenesis and function in the aging mammalian oocyte.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F06-J (20)]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Aging;Atherosclerosis;Biotechnology;Cardiovascular;Gene Therapy;Genetics;Orphan Drug;Pediatric;Rare Diseases;Regenerative Medicine

ORG_CITY: DURHAM

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: DUKE UNIVERSITY

PHR: PROJECT NARRATIVE Hutchinson-Gilford Progeria Syndrome (HGPS) is a fatal genetic disease that currently has no cure and very few treatment options, with the primary cause of death resulting from severe fibrotic atherosclerosis. The proposed research will investigate the contributions of different vascular cells to HGPS-induced atherosclerosis and will evaluate the efficacy of a new genetic therapy in an in vitro human vascular model of the disease. This work will provide invaluable information for the design and clinical translation of future HGPS therapies, as well as demonstrate the utility of microphysiological systems for studying disease and testing novel therapeutics.

PI_NAMEs: SHORES, KEVIN  (contact)

PROGRAM_OFFICER_NAME: NEILSON, KAREN MARY

PROJECT_TERMS: Abate;Adenine;Affect;Age;age acceleration;aging related disease;Animal Model;Atherosclerosis;base editing;base editor;Blood Vessels;calcification;Cardiovascular system;Cause of Death;cell type;Cells;Characteristics;Clinic;Clinical;clinical translation;defined contribution;Dependovirus;Deposition;design;Disease;disease model;disease phenotype;Disease Progression;Disease regression;DNA sequencing;Dose;efficacy evaluation;efficacy testing;Endothelial Cells;Environment;Event;Exhibits;Extracellular Matrix;Fibroblasts;Fibrosis;Functional disorder;Future;gene therapy;Generations;Genes;Genetic Diseases;Genetic Engineering;Genetic Variation;Goals;Human;Human Genetics;human model;improved;In Vitro;in vivo;Individual;Inflammation;Lamin Type A;Life Expectancy;Longevity;microphysiology system;Modeling;mouse model;Mutation;mutation correction;Myocardial Infarction;new technology;new therapeutic target;next generation;novel therapeutics;Nuclear;Paracrine Communication;Pathologic;Pathology;Patients;Physiological;Play;Point Mutation;Premature aging syndrome;Production;Progeria;Proteins;Research;Role;Signal Transduction;Smooth Muscle Myocytes;Stroke;Syndrome;System;targeted treatment;Testing;Therapeutic;Tissue Engineering;Tissues;Translating;Tunica Adventitia;Vascular calcification;Vascular Diseases;Vascular Smooth Muscle;Work

PROJECT_TITLE: Investigating the Effects of Hutchinson-Gilford Progeria Syndrome Mutation Correction in Tissue-Engineered Blood Vessels

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F10C-B (20)]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Genetics;Lewy Body Dementia;Neurodegenerative;Neurosciences;Parkinson's Disease

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Project Narrative Parkinson’s Disease (PD) arises from a complex interaction between age, genetic composition, and environmental factors that ultimately lead to the loss of cellular identity and death in the dopaminergic cells of the substantia nigra pars compacta (SNpc), leading to altered SNpc signaling to striatal and various cortical and limbic system brain regions. This project will employ a combination of cutting-edge biochemical, molecular, and behavioral techniques to examine the novel role dopamine plays as an epigenetic modification of histone 3 in the SNpc and post-synaptic BA25 prefrontal cortex of PD. The new mechanistic insights on how histone 3 dopaminylation impacts transcriptional identity, cell survival, and motor and cognitive functioning will offer enormous potential on novel targets for therapeutics.

PI_NAMEs: CHEN, WINNIE  (contact)

PROGRAM_OFFICER_NAME: ST  HILLAIRE-CLARKE, CORYSE

PROJECT_TERMS: Active Sites;Affect;Age;Aging;Alanine;Alzheimer's disease pathology;Alzheimer's disease related dementia;Amygdaloid structure;Architecture;attenuation;Autopsy;Behavior;Behavioral;Biochemical;Biological Assay;Bradykinesia;Brain;Brain region;Cell Death;Cell Nucleus;Cell Survival;Cells;Cessation of life;Chemicals;ChIP-seq;Chromatin;Chromatin Structure;Cognition;Cognitive;cognitive function;Complex;conditioned fear;Corpus striatum structure;Coupled;Data;data integration;Dementia;Diagnosis;disease model;Disease Progression;Dominant-Negative Mutation;Dopamine;Dopaminergic Cell;dopaminergic neuron;Emotions;Environmental Risk Factor;enzyme activity;Enzymes;epigenetic marker;Epigenetic Process;epigenetic regulation;Equilibrium;Functional disorder;Gene Expression;Gene Targeting;Genetic;Genetic Transcription;genome-wide;Glutamine;Goals;Hippocampus;Histone Deacetylase Inhibitor;histone demethylase;histone methylation;histone modification;Histones;Human;in vivo;Incidence;inhibitor;innovation;insight;Institution;interest;Lateral;Learning;Limbic System;Link;Lysine;Medial;Mediating;Medical;medical schools;Memory;Methylation;Mitochondria;Modeling;Modification;Molecular;Motor;motor deficit;mouse model;Movement;Multiplexed Analysis of Projections by Sequencing;Mus;Mutate;Nerve Degeneration;Nervous System;Neurodegenerative Disorders;neuroprotection;Neurotransmitters;new therapeutic target;novel;Nuclear;object recognition;Output;Oxidative Stress;Parkinson Disease;Parkinson's Dementia;pars compacta;Pathology;Patients;Persons;Pharmaceutical Preparations;Phenotype;Physicians;Play;Positioning Attribute;Post-Translational Protein Processing;postsynaptic;Prefrontal Cortex;preservation;prevent;Process;programmed cell death protein 1;Proteins;proteostasis;Rattus;Regulation;Research;Rest Tremor;Rewards;Role;Rotarod Performance Test;Sampling;Science;Severities;Signal Transduction;Site;skills;Sorting;Source;Structure;Substantia nigra structure;symptom treatment;Symptoms;Techniques;Testing;theories;Therapeutic;Tissues;Training;transcriptome sequencing;transcriptomics;transglutaminase 2;Translating;Transposase;Tyrosine 3-Monooxygenase;United States;vector;vector control;Ventral Tegmental Area;Viral;Work

PROJECT_TITLE: Investigating Histone 3 Dopaminylation in Parkinson's Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F03C-K (20)]


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Genetics;Orphan Drug;Pancreatic Cancer;Rare Diseases

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: PROJECT NARRATIVE Pancreatic ductal adenocarcinoma (PDA) is currently the third leading cause of death from cancer in men and women and is projected to be the second leading cause of cancer deaths by 2030. This proposal aims to provide critical insights into how SIRT6 regulates cellular response to transcriptional inhibitors in PDA. Ultimately, we hope that our research will inform the design of future clinical trials, providing new options and hope for patients with this devastating disease.

PI_NAMEs: WALLACE-POVIRK, ADRIANNE  (contact)

PROGRAM_OFFICER_NAME: ODEH, HANA M

PROJECT_TERMS: Acceleration;activating transcription factor 4;Affect;Aging;anti-cancer research;Apoptosis;ATF6 gene;attenuation;Basal Cell;beta-Transducin Repeat-Containing Proteins;Binding;biological adaptation to stress;Cancer Center;Cancer Etiology;career;Cause of Death;CDK4 gene;Cells;Cellular Stress;Cessation of life;chemotherapy;Classification;Clinic;clinical translation;Clinical Trials;clinically relevant;Collaborations;collaborative environment;Complex;cost effective;Coupled;Cyclin-Dependent Kinase Inhibitor;Cyclin-Dependent Kinases;Data;design;Disease;DNA Damage;Dose;Epigenetic Process;Eukaryotic Initiation Factors;Fellowship;Future;gemcitabine;Genes;Genetic Engineering;Genetic Transcription;Genetically Engineered Mouse;Genome Stability;Goals;Growth;high-throughput drug screening;Histone Deacetylase;Homeostasis;Immunocompetent;in vivo;Induction of Apoptosis;inhibitor;insight;KRAS oncogenesis;Laboratories;Malignant neoplasm of pancreas;Malignant Neoplasms;Mediating;men;Mentors;Minor;Modeling;Molecular;mouse model;neoplastic cell;Newly Diagnosed;novel;overexpression;Pancreas;pancreatic cancer patients;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma model;pancreatic neoplasm;Pathway interactions;patient derived xenograft model;Patients;Pharmaceutical Preparations;Phosphorylation;Phosphotransferases;Population;Postdoctoral Fellow;Prevention Measures;Prognosis;Prognostic Factor;programs;promoter;Protein Dephosphorylation;Protein phosphatase;Proteins;Regulation;Research;Resistance;resistance mechanism;response;Role;screening;sensor;Sirtuins;Stress;Survival Rate;targeted agent;targeted treatment;Therapeutic;Training Support;Transcript;transcription factor;Translating;Translational Regulation;Translations;tumor;Tumor Biology;tumor microenvironment;Tumor Suppressor Proteins;ubiquitin-protein ligase;Weather;Woman;Work

PROJECT_TITLE: Exploring the molecular mechanisms controlling CDK7i sensitivity in pancreas cancer


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Social Determinants of Health

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Clinical notes can be leveraged to understand how adverse social drivers/determinants of health impact the health outcomes of infants discharged from the neonatal intensive care unit (NICU). Natural language processing (NLP) offers a major opportunity to efficiently identify and extract social risk factors from NICU clinical notes. This study aims to: 1) use Bidirectional Encoder Representations from Transformer (BERT) based NLP models to identify and extract social risk factors from NICU clinical notes; and 2) use both structured (ICD diagnosis codes) and unstructured (clinical notes) electronic health record data to understand how social risk factors are associated with hospital readmissions among infants discharged from the NICU.

PI_NAMEs: MEHTA, SHIVANI  (contact)

PROGRAM_OFFICER_NAME: PADGETT, LYNNE SLAUGHTER

PROJECT_TERMS: Academy;Address;Admission activity;American;career;Caring;Classification;Clinical;Clinical Data;clinical decision-making;Clinical Informatics;clinical practice;Clinical Research;Clinical Services;Code;Competence;Consumption;Data;Data Collection;Data Science;Diagnosis;disparity reduction;electronic health data;Electronic Health Record;electronic health record system;electronic structure;Emergency department visit;Ethnic Origin;experience;Exposure to;Face;Family;Food;Goals;Health;health determinants;health disparity;health equity;health inequalities;Health Services Research;hospital readmission;Hospitals;Housing;improved;Income;Inequity;Infant;Infant Care;Infant Health;infant outcome;Knowledge;Length of Stay;Literature;Lived experience;Manuals;Measurement;Measures;Mentors;Mentorship;Methodology;Methods;model generalizability;Modeling;National Institute on Minority Health and Health Disparities;Natural Language Processing;Neonatal Intensive Care;Neonatal Intensive Care Units;Ontology;Outcome;patient population;Patients;Pediatric Hospitals;Pediatrics;Performance;poor health outcome;pre-trained transformer;Predictive Factor;prevent;primary outcome;Process;Race;readmission rates;Recommendation;Research;Research Personnel;Risk;Risk Factors;screening;Screening procedure;self supervised learning;Semantics;skills;social;social epidemiology;social health determinants;social skills;Statistical Data Interpretation;Structure;structured data;Time;Training;United States;unstructured data;Validation;Vocabulary

PROJECT_TITLE: A natural language processing approach to identify social risk factors from neonatal intensive care unit patients’ (NICU) electronic health records


NIH_SPENDING_CATS: Microbiome;Nutrition

ORG_CITY: LA JOLLA

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE The microbiome plays a large role in host health and physiological functioning but the mechanisms by which hosts recruit microbes is largely unknown. This study leverages the microbiomes of unicellular algae as a model system to assess the main drivers of microbiome assembly and the resulting physiological effect that these microbiomes have on host organisms. By approaching this question from an evolutionary perspective, the results of this study will have implications for all eukaryotic organisms, ultimately leading to new insights as to why microbiomes might fail in disease and how we might generate new microbiome-based therapeutics.

PI_NAMEs: BROE, TARYN  (contact)

PROJECT_TERMS: 16S ribosomal RNA sequencing;Address;Affect;Algae;Bacteria;Biological Availability;Biological Models;Carbon;Cell Physiology;Cells;Cellular Morphology;Cellular Stress;Characteristics;climate change;Communities;Data;Diet;Disease;Distant;Eating;Ecosystem;Environment;Esters;Eukaryota;Evolution;expectation;experimental study;Fatty Acids;Feeds;fitness;Food;Fresh Water;Gastrointestinal Diseases;Genetic;Health;Hominidae;host microbiome;Human;insight;Knowledge;Life;Lipids;Measurement;Measures;Membrane;Metagenomics;Microbe;microbial;microbial community;microbiome;microbiome composition;microbiome therapeutics;Mucous body substance;Neurodevelopmental Disorder;Nitrogen;Nutrient;Nutritional;Nutritional Requirements;Organism;Phosphorus;Phylogenetic Analysis;Phylogeny;Physiological;Physiology;Phytoplankton;Plants;Play;Population;Prokaryotic Cells;Recording of previous events;recruit;Regulation;response;Ribosomal RNA;Role;sample archive;Sampling;Shotgun Sequencing;Shotguns;Skin;Specificity;Taxonomy;Testing;trait;Translating;Transplantation;Vitamins;Water;Work;Zooplankton

PROJECT_TITLE: Identifying the Drivers and Consequences ofHost-Microbiome Composition and Function

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F07A-B (20)]


ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE The ability of neurons to process information underlies every one of our sensations, decisions, and actions, but the specific operations neurons can compute in vivo are unknown. Leveraging cutting-edge technologies, this study will characterize and model the diverse set of computations that individual neurons in living organisms perform. As genes coding for proteins involved in the computational properties of neurons have been implicated in several neurological diseases, including autism spectrum disorder and schizophrenia, deeper insights into how neurons compute will revolutionize our understanding of how these diseases affect cognitive function in patients.

PI_NAMEs: XIE, MICHAEL EVEREST (contact)

PROGRAM_OFFICER_NAME: VAN'T VEER, ASHLEE VICTORIA

PROJECT_TERMS: 3-Dimensional;Action Potentials;Affect;Afferent Neurons;Algorithms;autism spectrum disorder;Automobile Driving;Behavior;behavioral study;Biological;Bipolar Disorder;Brain;brain machine interface;Cells;Code;Cognitive;cognitive function;cognitive process;Complex;Data;Dendrites;Diffuse;Disease;doctoral student;Esthesia;Event;experimental study;Functional Imaging;Future;Generations;Genes;Glutamates;Imaging Techniques;in vivo;Individual;information processing;insight;Learning;Maps;Measurement;Measures;Mediating;meter;Microscope;millisecond;Modeling;Mus;Nature;Nervous System Disorder;neural;neural circuit;neural model;neural network;Neurons;neuropsychiatric disorder;neurotransmission;neurotransmitter release;Neurotransmitters;novel;novel imaging technology;novel strategies;operation;Organism;Output;Patients;Pattern;Physicians;Process;Property;Proteins;Research;Resolution;Rewards;Schizophrenia;sensor;Signal Transduction;skills;Source;spatiotemporal;Speed;Synapses;Technology;Testing;Thinking;Training;two photon microscopy;two-photon;Vesicle;Work

PROJECT_TITLE: STUDYING SINGLE NEURON COMPUTATIONS WITHIN BRAIN-WIDE CIRCUITS

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F03B-L (20)]


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Genetics;Lung;Pediatric

ORG_CITY: BIRMINGHAM

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Project Narrative Alveolar bone and periodontal bone loss and tooth fractures are common and require costly repairs. Low alveolar bone mass often results in tooth loss, implant failure, difficulty with chewing and speaking, and psychological insecurities. Elucidating the molecular mechanism by which odontoblasts and osteoblasts contribute to the mineralized matrix in the teeth and jaw bones may open new therapeutic targets for patients with dentin and alveolar bone defects.

PI_NAMEs: SMITH, CARIS MULHERN (contact)

PROGRAM_OFFICER_NAME: FUQUA, CHANTEL FAYSAN

PROJECT_TERMS: Adult;Affect;age related;Alveolar;alveolar bone;Alveolar Bone Loss;Ameloblasts;Apoptosis;autosome;Biology;bone;Bone Development;bone health;Bone Marrow Cells;bone mass;Bone Regeneration;bone repair;care costs;cDNA Library;Cell Communication;Cell Lineage;Cells;Cervical;Chondrocytes;clavicle;Cleavage Under Targets and Release Using Nuclease;Cleidocranial Dysplasia;Clinical;Computer Analysis;cost;craniofacial;craniofacial bone;craniomaxillofacial;Data;Data Set;Defect;Dental;Dental Enamel;Dentin;Development;differential expression;Disease;Embryo;Environment;Exhibits;experience;experimental study;Facilities and Administrative Costs;Failure;feeding;Femur;fluorexon;Fracture;Gene Deletion;Gene Expression;Gene Expression Profile;Genes;Goals;Health system;Human;Impairment;Implant;Incisor;Institution;Jaw;Knowledge;Label;Life;long bone;Mandible;Mastication;maxillofacial;mechanical force;mechanical load;microbiome;microCT;mineralization;Modeling;Molecular;mouse model;Mus;Mutation;Natural regeneration;new therapeutic target;Newborn Infant;novel therapeutics;Odontoblasts;Oral;Oral health;Organ;Orthopedics;Osteoblasts;Osteogenesis;Osteopenia;Osteoporosis;pathogen exposure;Pathway interactions;Patients;Periodontitis;Physiologic Ossification;Physiological;Population;postnatal;Proliferating;Proteins;psychologic;reconstruction;Regulation;repaired;Reporter;Research Personnel;Rest;restorative dentistry;Role;Scientist;Signal Pathway;Signal Transduction;single-cell RNA sequencing;skeletal;skeletogenesis;Structure of fontanel of skull;Supernumerary Tooth;Surgeon;Surgical sutures;targeted treatment;Testing;therapeutic target;Tissues;Tooth Fractures;Tooth Loss;Tooth structure;Training;transcription factor;Western Blotting;Work

PROJECT_TITLE: Role of Runx2 in Postnatal Dentin Synthesis and Alveolar Osteogenesis

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Digestive Diseases;Immunotherapy;Inflammatory Bowel Disease;Microbiome

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Project Narrative: This research aims to study how the body develops tolerance towards the expansive host of microbial species residing within our gut. By determining the profile and function of a newly discovered type of white blood cell observed to dampen self-harming immune responses to microbes in our intestines, targeted therapeutic strategies can be developed to prevent or reduce imbalanced inflammatory responses in the intestinal environment. Ultimately, results from our work to define the essential cells involved in this process will expand our understanding of the relationship between host and its microbiota, while spurring new approaches to preventing and treating auto-inflammatory diseases such as inflammatory bowel disease (IBD).

PI_NAMEs: CHEN, FRANCIS M (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: adaptive immune response;Address;Antigen Presentation;Antigen-Presenting Cells;Autoimmune Diseases;autoinflammatory diseases;Behavior;CD4 Positive T Lymphocytes;Cell Communication;cell type;Cells;Characteristics;commensal bacteria;commensal microbes;common symptom;Consensus;Dendritic Cells;Development;Disease;draining lymph node;dysbiosis;Ecology;efficacy evaluation;Environment;Equilibrium;Generations;Goals;gut microbes;gut microbiota;Helicobacter hepaticus;Homeostasis;Human;Image;Immune response;Immunity;immunoregulation;Inflammation;Inflammatory;Inflammatory Bowel Diseases;Inflammatory Response;intestinal homeostasis;Intestines;intravital microscopy;Lamina Propria;Leukocytes;Lymphoid Cell;Maps;mesenteric lymph node;Microbe;microbial;microbial host;microbiota;Microscopy;migration;Modeling;Monitor;mouse model;Mouse Strains;multiple omics;Nature;novel strategies;Nuclear;Nutrient;pathobiont;pathogen;Pathogenicity;Peripheral;Personal Satisfaction;Play;Population;Population Heterogeneity;prevent;Process;programs;Regulatory T-Lymphocyte;Reporting;Research;Resolution;response;Role;Self-Injurious Behavior;Sentinel;T cell response;T-Lymphocyte;targeted treatment;Techniques;therapeutic development;Thymic epithelial cell;Tissues;transcription factor;Transgenic Mice;Work

PROJECT_TITLE: Investigating a RORgt-expressing antigen presenting cell required for peripheral Treg responses to gut microbiota

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F07B-G (20)]


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Epilepsy;Neurodegenerative;Neurosciences

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

PHR: Project Narrative Overall, this proposal will investigate the functional utility of stereotyped HFOs by capturing them with a new implantable system (Brain Interchange - BIC of CorTec), which can sample neural data at higher rates >=1kHz and deliver targeted electrical stimulation to achieve seizure control. In contrast to current closed-loop systems (RNS), which wait for the seizure to start before delivering stimulation, the BIC system will monitor the spatial topography and rate of stereotyped HFOs and deliver targeted stimulation to these HFO generating areas to prevent seizures from occurring. If the outcomes of our research in acute setting become successful, we will execute a clinical trial and run our methods with the implantable BIC system in a chronic ambulatory setting. 1

PI_NAMEs: INCE, NURI FIRAT (contact)

PROGRAM_OFFICER_NAME: GROSS, BROOKS ANDREW

PROJECT_TITLE: Acute Modulation of Stereotyped High Frequency Oscillations with a Closed-Loop Brain Interchange System in Drug Resistant Epilepsy

STUDY_SECTION: NSD

STUDY_SECTION_NAME: Neurological Sciences and Disorders C Study Section[NSD-C]


NIH_SPENDING_CATS: Cardiovascular;Duchenne/ Becker Muscular Dystrophy;Muscular Dystrophy;Pediatric;Rare Diseases

ORG_CITY: MINNEAPOLIS

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF MINNESOTA

PHR: PROJECT NARRATIVE Defects in hydrogen sulfide (H2S) metabolism have been implicated in dystrophin-deficient muscular dystrophy (namely, Duchenne muscular dystrophy, DMD), but the pathomechanism is not well understood. This proposal will elucidate the contribution(s) of chronic, systemic H2S supplementation to in vivo contractility, including protection from eccentric contraction-induced force loss, in the mdx mouse model of DMD in addition to defining the effects of low H2S levels on oxidative post-translational cysteine in mdx contractile proteins. This study will thus provide further insight into the mechanisms of contractile dysfunction in dystrophin-deficient muscular dystrophies, allowing for the generation of improved DMD therapeutics.

PI_NAMEs: FALLON, KATHERINE SAGE (contact)

PROGRAM_OFFICER_NAME: CHEON, YEWON

PROJECT_TERMS: 3-Mercaptopyruvate sulfurtransferase;5 year old;Actins;Age;Animal Model;Automobile Driving;Biochemistry;Cardiac;Cardiomyopathies;Cessation of life;chemoproteomics;Chronic;Clinical;clinical care;clinical training;Contractile Proteins;Cysteine;Cytoskeleton;Data;Defect;design;Development;Disease;Doctor of Philosophy;Dose;Duchenne muscular dystrophy;Dystrophin;enzyme pathway;Enzymes;experimental study;extensor digitorum;Extracellular Matrix;Fibrosis;Functional disorder;Generations;Health;Heart;Hindlimb;Human;Hydrogen Sulfide;improved;In Vitro;in vivo;Inflammation;Inherited;insight;interest;Life Expectancy;Literature;Maintenance;mdx mouse;Measures;Metabolism;mouse model;Muscle;Muscle Weakness;Muscular Dystrophies;Myocardium;Neuromuscular Diseases;oxidation;Oxidation-Reduction;Pathway interactions;Patients;Phenotype;Physicians;Physiology;Play;Post-Translational Protein Processing;pre-clinical;Predisposition;preservation;prevent;Prevention;Production;Productivity;protein function;Proteins;Proteome;Reactive Oxygen Species;Reproducibility;Research Proposals;Research Training;Respiratory Diaphragm;Respiratory Insufficiency;Role;Sarcolemma;Scientist;Skeletal Muscle;skeletal muscle weakness;Sodium;Stress;Striated Muscles;Sulfhydryl Compounds;Supplementation;Testing;Therapeutic;Time;Tissues;Torque;Training;Translational Research;Treatment Efficacy;Work

PROJECT_TITLE: Contribution of hydrogen sulfide to Duchenne muscular dystrophy pathophysiology

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F10B-Q (20)]


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

NIH_SPENDING_CATS: Genetics;Hematology;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: Project Narrative The average adult generates >2 million red blood cells per second. The process of generating a mature red blood cell from a committed progenitor is complex, and defects in this process result in anemia. The goal of this proposal is to understand how the regulation of RNA polymerase II controls red blood cell production.

PI_NAMEs: STEINER, LAURIE A. (contact)

PROGRAM_OFFICER_NAME: HATTANGADI, SHILPA MANOHAR

PROJECT_TERMS: Adult;Anemia;Bromodomain;Cell Cycle;Cell Cycle Progression;Cell Physiology;cell type;Cells;Complex;Data;Defect;Development;Diamond-Blackfan anemia;Disease;Environment;Erythroblasts;Erythrocytes;Erythroid;Erythroid Cells;Erythropoiesis;Failure;GATA1 gene;Gene Expression;Gene Expression Profile;Gene Expression Regulation;gene function;Genes;Genetic Transcription;Genomics;Goals;Homeostasis;Hypoxia;improved;Inherited;insight;Investigation;Malignant - descriptor;Mediator;Molecular;Multipotent Stem Cells;new therapeutic target;novel;Phosphorylation;Phosphotransferases;Play;prevent;Process;Production;progenitor;programs;Proliferating;promoter;Pronormoblasts;Proteins;Publishing;recruit;Regulation;Regulator Genes;Repression;response;RNA Polymerase II;Role;self-renewal;Signal Pathway;Signal Transduction;Site;stem cell function;Stress;System;Testing;transcription factor;Transcription Initiation Site;Transcription Repressor;Transcriptional Elongation Factors;Transcriptional Regulation;transcriptome;Work

PROJECT_TITLE: Investigation into the function of RNA polymerase II promoter proximal pausing during terminal erythroid maturation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IVBH-V (03)]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Prevention

ORG_CITY: ROLLA

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: MISSOURI UNIVERSITY OF SCIENCE & TECHNOLOGY

PHR: Project Narrative - Green Solutions for Future Public Health Leaders: International PhytoScholars Program - 2024 The PhytoScholars program will train and inspire the next generation of professionals and academic researchers in public health protection as part of the 18th Annual International Phytotechnologies Conference in at the University of Calicut, Kerala, India. PhytoScholars program will increase knowledge of the broader roles of phytotechnologies in the concurrent protection of public health, risk assessment and the improvement of ecosystem function and provide students with professional skills and development opportunities and the chance to network with international professionals working in the field of phytotechnologies. The PhytoScholars will directly support student training, international engagement, mentorship and education in phytotechnologies and sustainable technologies as strategies for environmental remediation, management, and stewardship.

PI_NAMEs: BURKEN, JOEL G. (contact)

PROGRAM_OFFICER_NAME: TROTTIER, BRITTANY

PROJECT_TERMS: benefit sharing;Canada;career;Chemical Engineering;Chemistry;Cities;college;Committee Members;Complex;Delaware;Detection;Development;Discipline;Ecosystem;Education;Environment;Environmental Exposure;Environmental Health;Environmental Risk Factor;Exposure to;Feedback;Fees;Future;Goals;Hazardous Chemicals;Health;Health protection;Human;improved;India;Infrastructure;innovation;International;Italy;Knowledge;Learning;Link;Massachusetts;meetings;Mentors;Mentorship;mid-career faculty;Military Personnel;Mission;Missouri;multidisciplinary;Names;National Institute of Environmental Health Sciences;Nationalities;next generation;Plants;Postdoctoral Fellow;Process;professional students;professor;programs;Public Health;remediation;Research;Research Personnel;Risk Assessment;Role;Running;Scholars Program;Science;Scientist;Services;Signal Recognition Particle;skills;Societies;Specific qualifier value;STEM field;student participation;student training;Students;symposium;Technology;Training;Travel;Underrepresented Populations;Universities

PROJECT_TITLE: Education of Environmental Leaders of the Future: International Phytotechnologies Scholars Program - 2024

STUDY_SECTION_NAME: Special Emphasis Panel[ZES1 ARL-W (R)]


ED_INST_TYPE: UNIVERSITY-WIDE

ORG_CITY: STORRS-MANSFIELD

ORG_NAME: UNIVERSITY OF CONNECTICUT STORRS

PHR: PROJECT NARRATIVE Hypertension is a is a leading cause of death, and evidence suggests that disordered breathing (commonly associated with hypertension) contributes to development and maintenance of high blood pressure. Here, I will determine how respiratory neurons are disrupted in a spontaneously hypertensive rat (SHR) model of hypertension, and I will test whether treatments that improve respiratory function also improve blood pressure in this model. I expect results of this work to yield novel insight regarding therapeutic targets for treatment of cardiorespiratory function in hypertension.

PI_NAMEs: JOLLY, MICHAEL ALLEN (contact)

PROJECT_TERMS: Ablation;Acids;Animal Model;Animals;Apnea;arteriole;Astrocytes;Behavior;Blood;Blood flow;Blood Pressure;Blood Vessels;Brain;Breathing;candidate identification;Carbon Dioxide;Cardiovascular system;Cause of Death;Cell Nucleus;Chemoreceptors;Coupled;Data;Development;Disease;Disease Progression;Electrophysiology (science);Elements;Excision;Exhibits;Exposure to;Functional disorder;Goals;Heart Diseases;Heart failure;Hyperactivity;Hypertension;hypertensive;Hyperventilation;Image;imaging approach;improved;Inbred SHR Rats;insight;Maintenance;Mediating;Modeling;Molecular;Neurons;new therapeutic target;novel;Outcome;P2Y2 receptor;Patients;Periodicals;pharmacologic;Rattus;Reflex action;Regulation;Research Personnel;Respiration Disorders;respiratory;Respiratory physiology;response;Risk Factors;Site;Slice;Smooth Muscle Myocytes;Stimulus;Stroke;System;targeted treatment;Testing;therapeutic target;Tissues;Training;Vascular Smooth Muscle;vasoconstriction;Vasodilator Agents;Work

PROJECT_TITLE: Enhanced central chemoreception contributes to breathing problems in hypertension

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F10A-R (08)]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Immunotherapy;Skin Cancer

ORG_CITY: PHILADELPHIA

ORG_DEPT: PHARMACOLOGY

ORG_NAME: THOMAS JEFFERSON UNIVERSITY

ORG_STATE: PA

PHR: PROJECT NARRATIVE Melanoma is the deadliest form of skin cancer, and its incidence is rising. Following MAPK-targeted therapy, melanoma tumors often develop drug tolerance and minimal residual disease. To better understand the mechanisms behind acquired resistance in melanoma cells, this project aims to investigate altered signal transduction pathways and develop new therapeutic approaches to target drug-tolerant cells.

PI_NAMEs: OTT, CONNOR  (contact)

PROJECT_TERMS: 3-Dimensional;Antibodies;ATAC-seq;Award;Binding;Bioinformatics;Biological Assay;BRAF gene;cell growth;Cell Line;Cells;combinatorial;Communication;Complex;connective tissue growth factor;Critical Thinking;Cutaneous Melanoma;Data;Dependence;design;Drug resistance;Drug Targeting;Drug Tolerance;effective therapy;experimental study;Genetic Transcription;Goals;Growth;Human;immune checkpoint;Immune checkpoint inhibitor;In Vitro;in vitro Model;in vivo;Incidence;inhibitor;inhibitor therapy;knock-down;Knock-out;Laboratories;Learning;Luciferases;MAP Kinase Gene;Measures;Mediating;Mediator;MEKs;Melanoma;Melanoma Cell;Melanoma Tumor;minimally invasive;Modeling;Molecular;novel;novel therapeutic intervention;overexpression;Palmitates;paralogous gene;Pathway interactions;patient derived xenograft model;Population;programs;recruit;Regulation;Reporter;Residual Neoplasm;Resistance;response;RNA analysis;Science;Scientist;Signal Transduction;Signal Transduction Pathway;single-cell RNA sequencing;skills;Skin Cancer;spheroids;standard of care;targeted treatment;Techniques;Testing;Therapeutic;Training;transcription factor;Transcription Factor AP-1;transcriptome sequencing;transcriptomics;treatment strategy;tumor;tumor growth;Tumor-Infiltrating Lymphocytes;Universities;Up-Regulation;Work;Xenograft procedure

PROJECT_TITLE: Targeting TEAD in melanoma drug-tolerant persister cells

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F09B-Z (20)]


NIH_SPENDING_CATS: Brain Disorders;Cerebrovascular;Childhood Injury;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Stroke;Unintentional Childhood Injury

ORG_DEPT: PATHOLOGY

PHR: PROJECT NARRATIVE The development of the infant brain is a dynamic, intricate process that can be disrupted by oxygen deprivation, a frequent cause of long-term neurological disability. This proposal will generate gene expression profiles from normal and hypoxic human neonatal brain tissues and establish a piglet in vitro system to model effects of reduced oxygen levels on the developing infant brain. The findings from this research will enhance our understanding of neonatal hypoxic injury and guide future efforts towards therapeutic interventions.

PI_NAMEs: PODDAR, AUNOY  (contact)

PROGRAM_OFFICER_NAME: KIM, JENNY LILY

PROJECT_TERMS: Anatomy;Awareness;Behavior;Bioinformatics;Biological Models;Birth;Brain;brain cell;brain disorder therapy;brain tissue;cancer cell;career;Cell Death;cell motility;cell type;Childhood;cingulate cortex;Clinical;clinically relevant;Complement;CRISPR/Cas technology;critical period;CXCR4 gene;Data;deprivation;Destinations;Development;differential expression;Dorsal;Ensure;experience;experimental study;Exposure to;Fellowship;Foundations;Frequencies;Future;gene editing technology;Gene Expression Profile;Genes;Genetic;Genomics;Goals;Grant;Growth;Human;human disease;human model;Hypoxia;Hypoxia Inducible Factor;hypoxia neonatorum;Image;Immunohistochemistry;In Vitro;in vivo;infancy;Infant;Infant Development;Inflammatory;Injury;innovation;insight;Interneurons;knock-down;Knock-out;Knowledge;Learning;Life;Mediating;Mesenchymal Stem Cells;migration;Modeling;National Research Service Awards;Neonatal;neonatal brain;neonatal brain development;neonatal human;neuroblast;neurodevelopment;Neurodevelopmental Disorder;Neurological disability;Neurologist;neuronal survival;Neurons;neuroprotection;Neurosciences;Oligodendroglia;Outcome;Oxygen;Pathway interactions;Patients;Perinatal Brain Injury;porcine model;postnatal;postnatal period;Pregnancy;prenatal;Process;receptor;regenerative therapy;Research;response;Role;Route;Signal Pathway;Signal Transduction;single nucleus RNA-sequencing;skills;Slice;Stereotyping;Stream;Structure;System;Temporal Lobe;Testing;Therapeutic Intervention;Time;Training;transcription factor;Up-Regulation;white matter;white matter injury;Work

PROJECT_TITLE: Hypoxia-Induced Misdirection: Understanding Postnatal Inhibitory Interneuron Migration in Neonatal Hypoxic Injury

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F01A-V (20)]


NIH_SPENDING_CATS: Genetics;Infectious Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Women's Health Research

ORG_CITY: COLLEGE STATION

ORG_NAME: TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR

PHR: PROJECT NARRATIVE The dysregulation of normal reciprocal interactions between reproductive and immune systems can lead to diseases affecting one or both systems. As reproduction and immunity are energetically costly, the goal of this project is to determine the impact of sex-specific traits on metabolic responses and energetic trade-offs that define infection susceptibility. Characterizing the energetic trade-offs that underlie interactions between reproductive activity and immune responses will provide fundamental insight on how and why sexes differ when faced by similar pathogens.

PI_NAMEs: AUGUST, HEATHER  (contact)

PROGRAM_OFFICER_NAME: MOITRA, KAROBI

PROJECT_TERMS: Address;Adipose tissue;Adult;Affect;Atlases;Automobile Driving;Bacterial Infections;Behavior;Biochemical Pathway;biological sex;Cell Nucleus;cell type;Cells;Communication;Complex;Consumption;cost;Coupled;Coupling;Cues;Data;Development;Discipline;Disease;disease phenotype;Drosophila genus;Drosophila melanogaster;egg;Energy-Generating Resources;Ensure;Enteral;Event;Exhibits;Female;female sex hormone;fitness;fly;Gene Expression;Gene Expression Profiling;gene interaction;Generations;Genetic;Genetic Models;Genomic approach;Genomics;germline stem cells;Goals;Gonadal Steroid Hormones;Growth;hormonal signals;Human;Immune;Immune response;Immune system;Immunity;improved;Individual;Infection;Inflammatory;Innate Immune Response;insight;inter-individual variation;interest;Intestines;Life;life history;lipid metabolism;Lipid Mobilization;Lipids;male;male sex hormones;Maps;Men's Role;Metabolic;Metabolism;model organism;Modeling;Molds;Muscle;Natural Immunity;Nutritional;Organism;Outcome;Ovary;Partner in relationship;pathogen;pathogenic bacteria;Pathogenicity;Phenotype;Physiological;Population;Predisposition;pressure;Proteins;Regulation;Reproduction;reproductive;Reproductive Physiology;Reproductive system;Resolution;response;Role;Scientist;sex;sex linked trait;Shapes;Signal Pathway;Site;stem cell expansion;Stimulus;stressor;sugar;System;Techniques;Testing;Tissues;tool;Training;trait;transcriptomics;Variant;Whole Organism;Women's Role

PROJECT_TITLE: Genetic Modeling the Integration of Biological Sex, Immunity, and Metabolism


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Injury;Clinical Research;Emergency Care;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Mental Illness;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Suicide;Suicide Prevention;Violence Research;Youth Violence

PHR: PROJECT NARRATIVE Adolescent suicide is a growing public health problem and the rates of suicide deaths and suicidal behavior in the US have been on the rise for the last two decades. Parents play a central role in suicide prevention efforts, particularly during the critical period following ED discharge, but little is known about how to equip and support parents or address their needs while caring for an adolescent with suicidal behavior. This proposal is the first step in a research trajectory designed to address this critical gap in the field of adolescent suicide prevention research and inform the development of interventions to bolster the protective role of parents in preventing suicidal behavior and adolescent suicide.

PI_NAMEs: HENDERSON, MARCUS DARNELL (contact)

PROGRAM_OFFICER_NAME: CORNELL, ASHLEY ROSE

PROJECT_TERMS: 17 year old;Accident and Emergency department;Acute;Address;Adolescent;adolescent suicide;Affect;African American;Anxiety;Belief;Black race;caregiving;Caring;Cause of Death;Characteristics;Child;Child Rearing;Child Welfare;Clinical;Clinical Research;Competence;contextual factors;COVID-19 pandemic;critical period;Cross-Sectional Studies;Data;design;Discharge Plannings;Economics;Emergency department visit;Emotional;Ensure;environmental stressor;experience;Exposure to;Family;Funding;Future;Goals;Growth;Health;health disparity;high school;Individual;internalized stigma;Intervention;Interview;Knowledge;Life;Linear Regressions;Medical Care Team;Mental Health;Mental Health Services;Methods;Modeling;Monitor;National Institute of Mental Health;Not Hispanic or Latino;pandemic disease;parental influence;parental role;Parents;Pediatric Hospitals;physical conditioning;Play;prevent;Prevention;Prevention Research;protective factors;Psychosocial Factor;Public Health;racial discrimination;Recurrence;Reporting;Research;Research Infrastructure;Risk;Risk Factors;Role;Safety;School-Age Population;Self Efficacy;Self-Injurious Behavior;skills;social stressor;Social support;Socialization;Strategic Planning;Stress;Stressful Event;stressor;Subgroup;suicidal;suicidal adolescent;suicidal behavior;suicidal morbidity;suicidal risk;Suicide;Suicide attempt;Suicide prevention;suicide rate;Testing;therapy development;Time;trend;Youth

PROJECT_TITLE: Psychosocial Factors Associated with Parental Self-Efficacy in Adolescent Suicide Prevention

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F16-T (20)]


ORG_CITY: CHICAGO

ORG_NAME: LURIE CHILDREN'S HOSPITAL OF CHICAGO

PHR: PROJECT NARRATIVE With an ever-growing number of individuals seeking fertility preservation and restoration options, there is a critical need for the development and advancement of reproductive technologies. This work will establish an in vitro method for elucidating matrisome-dependent mechanisms in follicle growth and survival while also designing an enhanced biomimetic hydrogel for in vitro and in vivo applications. Ultimately, what is discovered through this work will improve fertility preservation and restoration options for a variety of individuals.

PI_NAMEs: MCDOWELL, HANNAH  (contact)

PROJECT_TERMS: Alginates;Antral;Biochemical;Biocompatible Materials;Biological;Biological Assay;Biological Availability;Biomimetic Materials;Biomimetics;Bioprosthesis device;Birth Rate;Body System;Cancer Survivor;cancer therapy;Cattle;Cell Proliferation;Child;Co-Immunoprecipitations;Communities;Cryopreservation;Cryopreserved Tissue;Cues;Data;design;Development;Diameter;egg;Elastin Microfibril Interfacer 1;Endocrine;Engineering;experience;Extracellular Matrix;Family suidae;Fertility;fertility improvement;fertility preservation;folliculogenesis;Foundations;Future;Generations;Glycoproteins;Goals;granulosa cell;Growing Follicle;Growth;Hormonal;Hormones;Human;Hydrogels;Image;Implant;improved;In Vitro;in vivo;Individual;Infertility;Influentials;innovation;life span;Live Birth;Longevity;Mediating;Methodology;Methods;Molecular;Mus;new technology;oocyte quality;Ovarian;Ovarian Follicle;Ovarian hormone;Ovarian Tissue;Ovarian tissue cryopreservation;Ovary;ovary transplantation;Patients;Phenotype;Population;post-transplant;Prevalence;primary ovarian insufficiency;Primordial Follicle;Process;Production;Proliferating;Proteins;Proteolysis;Proteomics;Regulation;reproductive;reproductive function;Reproductive Sciences;Reproductive Technology;Research;restoration;Reverse engineering;Role;Signal Pathway;Signal Transduction;subfertility;Testing;TGFB1 gene;Tissue Transplantation;Tissues;transcriptome;transcriptome sequencing;United States;Woman;Work

PROJECT_TITLE: Elucidating the mechanism by which Elastin Microfibril interface-located protein 1 (EMILIN1) contributes to folliculogenesis


NIH_SPENDING_CATS: Digestive Diseases

ORG_CITY: Nashville

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: PROJECT NARRATIVE While previous studies have implicated tuft cells in sensing intestinal parasites and activating an immune response, their rarity in the intestinal epithelium has impeded investigations on mechanisms underlying these functions. This project will use state-of-the art microscopy and biochemical approaches to investigate how the core actin bundles support tuft cell morphology and the role of tuft cell enriched, cytoskeletal-binding protein LIM domain and actin binding 1 (LIMA1) in driving the formation of the tuft cell cytoskeletal structure. Tuft cells are recognized for their importance in maintaining the health of the intestinal epithelium and this project holds implications for gastrointestinal health issues caused by intestinal parasites and for inflammatory illnesses such as Crohn’s Disease.

PI_NAMEs: SILVERMAN, JENNIFER  (contact)

PROGRAM_OFFICER_NAME: DENSMORE, CHRISTINE L

PROJECT_TERMS: Actin-Binding Protein;Actins;Affect;alpha catenin;Animals;Antibodies;Apical;apical membrane;Architecture;Automobile Driving;Binding;Binding Proteins;Biochemical;Biological Models;Cartoons;Cell Count;Cell Culture Techniques;Cell Differentiation process;Cell Physiology;cell type;Cells;Cellular biology;cellular microvillus;Cellular Morphology;Crohn's disease;crosslink;Crosslinker;Cytoplasm;Cytoskeletal Proteins;Cytoskeleton;Data;Data Set;Defect;depolymerization;Development;Electron Microscopy;Enterocytes;Epithelial Cells;experimental study;F-Actin;Fluorescence Recovery After Photobleaching;gastrointestinal;Gastrointestinal Physiology;Goals;Health;Hela Cells;Human;Hyperplasia;Image;Immune;Immune response;Immunofluorescence Immunologic;immunoregulation;In Vitro;Inflammatory;insight;Interleukin-13;intestinal epithelium;Intestinal parasite;Intestines;Investigation;Knockout Mice;light microscopy;LIM Domain;LIM Domain Protein;Literature;live cell imaging;Location;loss of function;Microfilaments;Microscopy;Modeling;Molecular;monolayer;Morphology;mouse model;Mus;novel;Nuclear;nutrient absorption;Organoids;overexpression;Pathway interactions;Phenotype;Physiological;Polymers;prevent;Proteins;Publishing;recruit;Research;Role;Sensory;sensory mechanism;Small Intestines;Stains;Structure;Testing;Tissues;transcriptomics;Transmission Electron Microscopy;Visualization

PROJECT_TITLE: The Role of LIMA1 in the Formation of the Giant Core Actin Bundles in Tuft Cells

STUDY_SECTION_NAME: Fellowships in Digestive Diseases and Nutrition[DDK-F]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE This project studies how a subject learns to obtain rewards in a space by observing another subject’s actions. We will identify neural activities underlying this type of learning task and investigate how task performance can be altered by behavioral and neural circuit manipulations. The outcomes of this study will advance our understanding of neural mechanisms in observational learning and generate insights into how observational learning is impaired in mental disorders.

PI_NAMEs: JI, DAOYUN  (contact)

PROGRAM_OFFICER_NAME: RANGEL GOMEZ, MAURICIO

PROJECT_TERMS: Animals;Anterior;Area;Auditory;autism spectrum disorder;Aversive Stimulus;Behavior;behavior test;Behavioral;Behavioral Mechanisms;behavioral study;Brain;Cells;Child;cingulate cortex;Code;Cognitive;cognitive function;Data;density;Detection;Familiarity;Fire - disasters;Fright;Future;Goals;Hippocampus;Human;Impairment;insight;Knowledge;Learning;Location;Mental disorders;Modality;neural;neural circuit;neuromechanism;Neurons;novel;optogenetics;Outcome;Outcome Study;Parents;Patients;Pattern;Performance;Phase;Play;Process;Rattus;Rewards;Role;Running;Sensory;Short-Term Memory;Signal Transduction;social;Social Dominance;social factors;social learning;social relationships;Stimulus;Task Performances;Testing;Thinness;Time;Visual

PROJECT_TITLE: Neural circuit mechanisms in observational spatial working memory

STUDY_SECTION: LMDN

STUDY_SECTION_NAME: Learning, Memory and Decision Neuroscience Study Section[LMDN]


ED_INST_TYPE: HOSPITALS

FUNDING_MECHANISM: RESEARCH CENTERS

NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Colorectal Cancer;Digestive Diseases;Immunotherapy;Infectious Diseases;Rare Diseases

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: Narrative Tumoral bacterial have been shown by our group and others to be present in rectal cancers and associated with a diminished response to neoadjuvant therapies. Through this work we propose to study antibiotic therapy to eradicate these deleterious microbes and studying the effect of this therapy on tumor immune populations. We anticipate this work will provide immediate insights into how microbial modulation can improve outcomes and increase rates of complete response in rectal cancer patients.

PI_NAMEs: DRAETTA, GIULIO FRANCESCO (contact)

PROGRAM_OFFICER_NAME: SHAFIK, HASNAA

PROJECT_TERMS: Adjuvant Chemotherapy;Aftercare;Anaerobic Bacteria;Antibiotic Therapy;Award;Bacteria;Bayesian Modeling;biomarker discovery;biomarker identification;Biopsy;Cancer Center Support Grant;Cancer Patient;cancer therapy;chemoradiation;chemotherapy;Clinical;cohort;Colorectal Cancer;Coupled;Distant;Eligibility Determination;Environment;Excision;Face;Failure;Feasibility Studies;Fluorouracil;Funding;Fusobacterium;Fusobacterium nucleatum;Future;gut microbiome;high risk;Immune;immune cell infiltrate;Immune response;immunoregulation;improved;improved outcome;In complete remission;insight;Institutional Review Boards;interest;Intervention;Knowledge;Metronidazole;Microbe;microbial;microbial community;mouse model;Neoadjuvant Therapy;Operative Surgical Procedures;Outcome;Pathologic;patient subsets;Patients;Population;Pre-Clinical Model;primary endpoint;Process;prospective;Protocols documentation;Rectal Cancer;Recurrence;response;response biomarker;Role;Safety;Scientist;Signal Transduction;Specimen;Surgeon;Therapeutic;Time;Tissues;transcriptomics;translational study;Triplet Multiple Birth;tumor;tumor-immune system interactions;Validation;Work

PROJECT_TITLE: CCSG Supplement: Early-Stage Surgeon Scientist (ESSP)

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Climate-Related Exposures and Conditions;Genetics;Human Genome;Pediatric;Pediatric Cancer;Rare Diseases;Skin Cancer

ORG_CITY: ALBUQUERQUE

ORG_NAME: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR

ORG_STATE: NM

PHR: PROJECTIVE NARRATIVE DNA repair is a fundamental process to maintain the integrity of the genome. This proposal investigates the molecular mechanism of Transcription Factor IIH (TFIIH) in the development of genetic disorders using high throughput sequencing methods and protein activity assays. The successful completion of this research will provide insights into underlying mechanisms for genetic disorders and the related diseases.

PI_NAMEs: HOAG, ALLYSON LYNNE (contact)

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TERMS: Acceleration;Address;Affect;Alkylation;associated symptom;base;Biochemical;Biochemistry;Bioinformatics;Biological Assay;Biological Models;Biometry;Cancer Etiology;cancer predisposition;career;Cells;Clinical;clinical phenotype;Clinical Research;Cockayne Syndrome;Complex;Coupled;Data;Defect;Development;Disease;DNA;DNA Damage;DNA Repair;DNA Repair Gene;DNA Repair Pathway;ERCC2 gene;Fellowship;Genes;Genetic Diseases;Genetic Transcription;Genome;genome integrity;Genome Stability;genome-wide;Genomics;Goals;helicase;High-Throughput Nucleotide Sequencing;Human;Human Cell Line;human disease;Human Genetics;Impairment;In Vitro;in vitro activity;insight;interdisciplinary approach;Knowledge;Lead;Lesion;Link;Measures;Methods;methylpurine;Modification;Molecular;Molecular Biology;mutant;Mutate;Mutation;Nerve Degeneration;neuron apoptosis;novel;Nucleotide Excision Repair;Pathway interactions;Patients;Phenotype;photolesion;Play;Predisposition;Premature aging syndrome;Process;protein complex;Protein Complex Subunit;Proteins;Publishing;Pyrimidine Dimers;recruit;repair enzyme;repaired;Research;RNA Polymerase II;Role;sensor;skills;Skin Cancer;Structural Models;Surgical incisions;Symptoms;Techniques;Testing;transcription factor TFIIH;Transcription-Coupled Repair;ultraviolet damage;Ultraviolet Rays;UV sensitive;whole genome;Work;Xeroderma Pigmentosum;Yeast Protein Complex;Yeasts

PROJECT_TITLE: The Molecular Mechanism of Genetic Disorders Due to XPD Mutations

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F08-L (20)]