NIH_SPENDING_CATS: Biomedical Imaging;Brain Disorders;Cardiovascular;Clinical Research;Epilepsy;Machine Learning and Artificial Intelligence;Neurodegenerative;Neurosciences;Prevention

ORG_DEPT: NEUROLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Project Narrative One in 1000 people with epilepsy die every year due to Sudden Unexpected Death in Epilepsy (SUDEP). Identifying risk factors associated with SUDEP remains challenging due to the lack of large controlled datasets enabling rigorous analyses and development of comprehensive prediction models. Our study will address this critical unmet need by screening records of >40,000 patients from >85 epilepsy centers worldwide to obtain a nearly order of magnitude more cases and controls than any prior study, and applying innovative methods to test candidate biomarkers, leading to better understanding of SUDEP mechanisms and developing individualized risk models to better target patients for counseling and interventions.

PI_NAMEs: DEVINSKY, ORRIN  (contact);FRIEDMAN, DANIEL ;LHATOO, SAMDEN

PROGRAM_OFFICER_NAME: WHITTEMORE, VICKY R

PROJECT_TERMS: Affect;Age;Amygdaloid structure;awake;Bayesian Modeling;Biological Markers;biomarker identification;biomarker performance;Bradycardia;brain magnetic resonance imaging;Brain Stem;candidate marker;Cardiopulmonary;case control;Case/Control Studies;Central Sleep Apnea;Cerebral Decortication;Characteristics;Clinic;Clinical;clinical care;clinical practice;clinical risk;cost;Counseling;Data;Data Collection;data harmonization;Data Set;Decerebration procedure;deep learning;Development;Disease;Electrocardiogram;Electroencephalography;Electrophysiology (science);epidemiology study;Epilepsy;Exhibits;Factor Analysis;follow-up;Frequencies;Functional disorder;Goals;Heart Arrest;heart rate variability;high risk;Hippocampus;Image;Individual;innovation;Intervention;Knowledge;Machine Learning;machine learning method;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;magnetic resonance imaging/electroencephalography;Measures;Methods;Modeling;Monitor;Multicenter Studies;National Institute of Neurological Disorders and Stroke;neuroimaging marker;novel;novel marker;Outcome;Patients;Performance;personalized predictions;personalized risk prediction;Persons;Physiological;Posture;potential biomarker;predictive modeling;predictive tools;Premature Mortality;Prevention strategy;Probability;prospective;Prospective Studies;random forest;Records;Research;research clinical testing;Retrospective cohort;Risk;Risk Factors;risk prediction;risk prediction model;Sample Size;Scalp structure;screening;Seizures;Selection Bias;Severities;sex;Site;statistical and machine learning;Sudden Death;sudden unexpected death in epilepsy;Supervision;Techniques;Testing;Time;Tonic - clonic seizures;tool;United States National Institutes of Health

PROJECT_TITLE: Advancing SUDEP Risk Prediction Using a Multicenter Case-Control Approach

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


ADMINISTERING_IC: HD

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Social Determinants of Health

ORG_CITY: MADISON

ORG_COUNTRY: UNITED STATES

ORG_DEPT: SOCIAL SCIENCES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Project Narrative Individual and household debt has played an increasingly important role in the dynamics of economic inequality and insecurity in the United States in recent decades. However, limitations of current data impede scientific understanding of the role of indebtedness in reducing or exacerbating economic insecurity for low-income families. This project consists of a multi-pronged data collection and analysis effort aimed at building a stronger data infrastructure, more adequate and accurate measures of indebtedness, and best practices for analyzing various forms of indebtedness and their relation to economic hardship and financial strain for low-income families.

PI_NAMEs: BERGER, LAWRENCE M (contact);DWYER, RACHEL E

PROGRAM_OFFICER_NAME: CAPPS, RANDOLPH CHRISTOPHER

PROJECT_TERMS: Adult;Behavior;Characteristics;Child;Child Support;Cognitive;cognitive interview;cost;COVID-19 impact;COVID-19 pandemic;Data;Data Analyses;Data Collection;data infrastructure;data quality;Data Reporting;Demographic Analyses;Development;Disadvantaged;Disparity population;economic evaluation;economic impact;Economics;Education;Employment;Equipment and supply inventories;experience;experimental study;Family;Family Demographies;Financial Hardship;financial literacy;Friends;Goals;Health;health assessment;Heterogeneity;Household;improved;Income;Individual;Inequality;instrument;Intervention;Interview;Knowledge;Legal;Link;Low income;Low Income Population;lower income families;Mainstreaming;Measures;Middle Class Populations;Modeling;Patient Self-Report;Performance;Personal Satisfaction;Pilot Projects;Play;Policies;Population Analysis;population health;Poverty;programs;Qualitative Research;Questionnaires;Race;racial disparity;Randomized;Reporting;Research Design;Respondent;Role;Sampling;Security;social;Social Welfare;Social Work;sociodemographics;Source;Student Loan;Surveys;United States;Wisconsin;Work

PROJECT_TITLE: Improving Data Collection of Debt and Financial Strain to Assess Health Impacts of Economic Insecurity

STUDY_SECTION: SSPA

STUDY_SECTION_NAME: Social Sciences and Population Studies A Study Section[SSPA]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Lung;Orphan Drug;Rare Diseases;Tuberculosis

ORG_CITY: NOTRE DAME

ORG_NAME: UNIVERSITY OF NOTRE DAME

ORG_STATE: IN

PI_NAMEs: MILLER, MARVIN J (contact)

PROGRAM_OFFICER_NAME: BOYCE, JIM P

PROJECT_TERMS: Amides;animal efficacy;antibiotic tolerance;Antitubercular Agents;aqueous;Award;bactericide;Cessation of life;Clinical;clinical candidate;Collaborations;Communities;comparative efficacy;Complex;cost effective;cost effectiveness;Cytochromes;design;Development;Disease;Dose;Drug Combinations;drug development;Drug Interactions;Drug Kinetics;Drug resistance;Drug resistant Mycobacteria Tuberculosis;effective therapy;Evaluation;experience;extensive drug resistance;Genus Mycobacterium;global health;Goals;Growth;Human;Hypoxia;In Vitro;in vivo;Infection;inhibitor;Instruction;isoniazid;laboratory experience;Lead;Legal patent;Lung;Maximum Tolerated Dose;Metabolism;Microbe;Mitochondria;Molecular Weight;Monkeys;mouse model;Multi-Drug Resistance;Mus;Mycobacterium tuberculosis;nanomolar;novel;novel therapeutics;Nutrient;Oxidases;Oxidative Phosphorylation;pathogen;Persons;Pharmaceutical Preparations;Pharmacotherapy;Plasma;pre-clinical;Preparation;Primates;Property;Publishing;pyridine;Qualifying;rational design;Research;resistant strain;respiratory;Rifampin;Risk;Sampling;scaffold;Series;small molecule inhibitor;Solubility;Starvation;Thiazoles;Toxic effect;Tuberculosis;tuberculosis drugs;tuberculosis treatment

PROJECT_TITLE: Design, Syntheses and Studies of Novel Antituberculosis Agents

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Electronic Nicotine Delivery Systems;Lung;Lung Cancer;Prevention;Social Determinants of Health;Tobacco;Tobacco Smoke and Health

ORG_CITY: Bloomington

ORG_NAME: HEALTHPARTNERS INSTITUTE

ORG_STATE: MN

PHR: Project Narrative The popularity of e-cigarettes and other electronic nicotine delivery systems (ENDS), especially among youth, is compelling policymakers to reengineer tobacco control policy and is reigniting the debate on whether to accept ENDS for tobacco harm reduction or to apply the precautionary principle to ENDS. The level of reduction in population level harms conferred by ENDS may depend on the policy context, and likewise, the presence of ENDS in the marketplace may alter the impact of tobacco control policies on population level harm. This study will develop the first state-level microsimulation model to estimate the health and economic impact of intensive tobacco control policies, under scenarios with and without ENDS in the marketplace, in order to: 1) estimate the magnitude of the effect that ENDS presence has on a policy’s effect in reducing population harms of tobacco and 2) estimate the variation in population level harms attributable to ENDS over alternative policy contexts.

PI_NAMEs: MACIOSEK, MICHAEL V (contact)

PROGRAM_OFFICER_NAME: MAYNE, RACHEL G

PROJECT_TERMS: Adolescent;Adoption;Adult;Attenuated;Behavior;Binding;Biological Markers;Cardiovascular Diseases;Cigarette;combustible cigarette;cost effectiveness;Cost Savings;Country;Data Set;Disease;economic impact;economic outcome;Economics;Electronic cigarette;Electronic Nicotine Delivery Systems;Engineering;evidence base;Expenditure;experience;experimental study;former smoker;Funding;Future;Goals;Harm Reduction;Health;health assessment;health economics;Health Status;Individual;Knowledge;Literature;Malignant Neoplasms;Manufacturer;Medical Care Costs;Mental Health;Modeling;models and simulation;Nicotine;nicotine use;Pattern;Policies;Policy Maker;Population;population health;premature;Prevalence;Probability;programs;Public Health;public policy on tobacco;Recommendation;Research Personnel;residence;Respiratory Disease;Risk;simulation;Smoker;Smoking;statistics;Taxes;Time;timeline;Tobacco;tobacco control;tobacco products;Tobacco use;tool;Toxic effect;United States Food and Drug Administration;uptake;vaping;Variant;young adult;Youth

PROJECT_TITLE: The Interplay of ENDS and Tobacco Control Policy: Impact on the Population Harms of Tobacco


ADMINISTERING_IC: AR

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Chronic Pain;Clinical Research;Mental Health;Neurosciences;Pain Research;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: PORTLAND

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Project Narrative Identifying risk factors for persistent pain and disability in the context of acute musculoskeletal pain is key to preventing the development of chronic musculoskeletal pain in adolescence. Understanding neurobiological features and circuits that are underlying the risk for transition to chronic pain is particularly important in this developmental period, when brains are still developing and may be more amenable to intervention. The long- term goal of this research program is to identify risk and protective factors that contribute to chronic musculoskeletal pain, which will directly inform the development of preventative interventions for youth at increased risk.

PI_NAMEs: NAGEL, BONNIE J (contact);WILSON, ANNA CAMILLE

PROGRAM_OFFICER_NAME: WASHABAUGH, CHARLES H

PROJECT_TERMS: Acute;Acute Pain;Address;Adolescence;Adolescent;Adult;Age;age effect;Ankle;Back;Biological Factors;biopsychosocial;Brain;brain control;Characteristics;Childhood;Chronic disability;chronic musculoskeletal pain;chronic pain;Chronic pain syndrome;Cognition;Complex;cost;critical period;Data;Development;disability;Disabling;Disease remission;early adolescence;Emotional;emotional stimulus;Environmental Risk Factor;executive function;experience;Female;foot;Functional Magnetic Resonance Imaging;Goals;gray matter;Growth;Health Care Costs;Heterogeneity;Incidence;Individual;Intervention;Knee;Learning;Lower Extremity;Magnetic Resonance Imaging;Maintenance;Measures;Medial;Mental Health;Modeling;Moods;multimodal neuroimaging;multimodality;Musculoskeletal;Musculoskeletal Pain;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;neural;neural circuit;Neurobiology;neuroimaging;novel;novel therapeutic intervention;Nucleus Accumbens;Pain;pain catastrophizing;pain chronification;Pain Free;Pain Measurement;pain processing;pain symptom;Parents;Participant;Pathway interactions;Persistent pain;Phenotype;physical conditioning;Physicians;Population;Prefrontal Cortex;prevent;preventive intervention;Process;programs;prospective;protective factors;Proxy;Psychological Factors;psychosocial;Public Health;Quality of life;Recording of previous events;recruit;Regulation;Remittance;Reporting;Research;response;Rest;Risk;Risk Assessment;Risk Factors;Risk Reduction;Sampling;sex;societal costs;Strategic Planning;structural imaging;Structure;Subgroup;Symptoms;therapy design;Thick;Time;time use;United States National Institutes of Health;Vertebral column;Visit;Youth

PROJECT_TITLE: Neurobiological and psychosocial risk for transition from acute to chronic musculoskeletal pain in adolescence

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


NIH_SPENDING_CATS: Cystic Fibrosis;Infectious Diseases;Lung;Microbiome;Pediatric;Rare Diseases

ORG_CITY: AMHERST

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

ORG_STATE: NY

PHR: PROJECT NARRATIVE Culture-independent sequencing has revealed that strict and facultative anaerobic bacteria are both prevalent and abundant in in the CF airways, but their mechanistic contribution(s) to disease pathophysiology and long-term clinical outcomes are poorly understood. The focus of this project is to define how individual anaerobes interact with one another, the host, and traditional CF pathogens and to test our hypothesis that anaerobic microbiota set the stage for consequent disease trajectories. By understanding how anaerobes contribute to the development of early CF airway environment, we can identify new therapeutic strategies for more effective disease management and improved long-term patient outcomes.

PI_NAMEs: HUNTER, RYAN COULSON (contact)

PROGRAM_OFFICER_NAME: UPADHYAY, MEENU MISHRA

PROJECT_TERMS: Acute Disease;acute infection;Address;Aerobic;Aerobic Bacteria;Affect;Age;age group;Airway Disease;airway epithelium;Anaerobic Bacteria;Anoxia;Antibiotic susceptibility;Antimicrobial Resistance;Bacteria;bacterial community;Biological Models;bronchial epithelium;Bronchoalveolar Lavage Fluid;cell type;Cells;Childbirth;children with cystic fibrosis;Chronic;Chronic Obstructive Pulmonary Disease;chronic respiratory disease;Clinical;Clinical Research;Coculture Techniques;Complex;Coupled;Cystic Fibrosis;cystic fibrosis airway;cystic fibrosis patients;Data;density;Development;Disease;Disease Management;Disparate;early cystic fibrosis;Environment;Epidemiology;Epithelial Cells;Etiology;Evolution;experimental study;feeding;Flare;Fluorescent in Situ Hybridization;Functional disorder;Future;genome sequencing;Growth;Image;Immune response;Immunologics;Immunology;improved;In Vitro;in vitro Model;in vivo;Individual;Inflammation;Inflammatory;Inflammatory Response;innovation;insight;interdisciplinary approach;Knowledge;Laboratories;Lung;Lung Diseases;Lung infections;Mediating;Metabolism;microbial;Microbiology;microbiome;microbiota;microbiota composition;Modeling;Morbidity - disease rate;Mucins;Mutation;novel therapeutic intervention;Nutritional;Organism;Outcome;Oxygen;pathogen;Pathogenicity;Patient-Focused Outcomes;Patients;polymicrobial disease;Population;Prevalence;Prevotella;Process;Pseudomonas aeruginosa;Publishing;Pulmonary Cystic Fibrosis;pulmonary function;Reporting;respiratory colonization;respiratory microbiota;Respiratory Tract Infections;Role;Shapes;single-cell RNA sequencing;Sinusitis;Staphylococcus aureus;Streptococcus;Structure;System;targeted treatment;Testing;Therapeutic;Veillonella;ventilator-associated pneumonia;Virulence;whole genome;Work

PROJECT_TITLE: The role of anaerobic microbiota in cystic fibrosis airway disease trajectory

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IMII-U(01)]


ADMINISTERING_IC: NS

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Pediatric;Rare Diseases;Rural Health

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: The Network for Excellence in Neuroscience Clinical Trials (NeuroNEXT) aims to improve the efficiency and quality of clinical trials in order to enhance the translation of neuroscience discoveries into effective treatments for patients. The Utah regional site (UR-NEXT) provides access to NeuroNEXT trials to the diverse and rural population of the 5-state Intermountain West region. UR-NEXT strengthens NeuroNEXT network by providing leadership and clinical trial expertise in rare neurological disorders and genetic therapies for both pediatric and adult disease as well as a broad spectrum of collaborative programs and centers that can support the larger network. A training component provides structured mentorship and skill development to early stage clinical investigators.

PI_NAMEs: BONKOWSKY, JOSH LEITCH;SINGLETON, JOHN ROBINSON (contact)

PROGRAM_OFFICER_NAME: OHAYON, JOAN M

PROJECT_TERMS: Address;Adopted;Adult;Affect;Agreement;Autoimmune encephalitis;Award;biomarker development;biomarker validation;career;career development;Childhood;Cities;Clinical;clinical investigation;Clinical Investigator;clinical research site;Clinical Sciences;Clinical Trials;Clinical Trials Design;Clinical Trials Network;cohort;Collaborations;Communities;community engagement;Complex;Contracts;cost effective;COVID-19;Data;density;design;Development;Disease;disease phenotype;effective therapy;Enrollment;Environment;Ethnic Origin;experience;Face;Faculty;Feedback;Fellowship;frontier;Funding;gene therapy;Genome;Grant;Health;Health system;Healthcare;Home;Hospital Administration;Human Resources;improved;Infrastructure;innovation;Inpatients;Institution;Institutional Review Boards;interest;Leadership;leukodystrophy;life span;Master of Science;Measures;Medical;member;Mentorship;Multi-Institutional Clinical Trial;Multicenter Trials;N-Methyl-D-Aspartate Receptors;National Center for Advancing Translational Sciences;National Institute of Neurological Disorders and Stroke;nerve conduction study;Nerve Fibers;Nervous System Disorder;Neurobiology;Neurologic;Neurologist;Neurology;Neuropsychology;Neurosciences;Neurosciences Research;neurosurgery;novel;Only Child;Participant;participant retention;patient population;Patient Recruitments;Patients;Pediatric Hospitals;Pediatric Neurology;peer;Performance;Play;Population;Population Database;Population Heterogeneity;Positioning Attribute;primary endpoint;programs;protocol development;Protocols documentation;Race;Randomized;Randomized, Controlled Trials;Rare Diseases;recruit;Research;Research Personnel;Resource Development;Resources;retention rate;Role;Rural;Rural Population;rurality;Scholars Program;Secure;Services;Site;skill acquisition;skills;Sodium Chloride;Structure;success;System;Techniques;Therapeutic;Therapy trial;Training;Training Programs;translational neuroscience;Translational Research;trial design;Universities;Utah;Veterans Health Administration;Writing

PROJECT_TITLE: The Utah Regional Network for Excellence in Neuroscience Clinical Trials (UR-NEXT)


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Social Determinants of Health

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

PHR: Narrative IPUMS DHS opens the door to the richest source of health data on low- and middle-income countries, revealing new opportunities for over-time and cross-national comparative investigations of population health. Only with intuitive, online access to integrated data like IPUMS DHS can scientists and policymakers address the world’s most pressing population health issues, make progress toward international development goals, and shift the balance toward greater global health equity in the face of ongoing challenges.

PI_NAMEs: BOYLE, ELIZABETH H (contact);KING, MIRIAM L

PROGRAM_OFFICER_NAME: JEKIELEK, SUSAN

PROJECT_TERMS: Address;Africa;African;application programming interface;Area;Aridity;Asia;Asian;Caribbean region;Central Asia;Characteristics;Child;Code;Communities;comparative;Conflict (Psychology);Contraceptive methods;cost;Country;Coupled;Data;Data Analyses;Data Discovery;data integration;data management;Data Sources;Databases;Democracy;Demographic and Health Surveys;Desertification;Development;Diarrhea;Documentation;Eastern Europe;Educational workshop;empowerment;Equilibrium;Far East;Fertility;Food Safety;Funding;Geography;global health;Goals;Health;health care availability;health data;health determinants;health disparity;health equity;Health trends;high risk sexual behavior;Human Development;improved;indexing;Individual;innovation;International;interoperability;intimate partner violence;Intuition;Investigation;Investments;Latin America;Link;low and middle-income countries;Low Birth Weight Infant;Maternal Mortality;Mission;mortality;National Institute of Child Health and Human Development;Neonatal;Neonatal Mortality;new technology;novel;nutrition;Obesity;Oceania;online tutorial;Peer Review;Persons;Phase;Policy Maker;Population;Population Dynamics;population health;Publishing;Records;remote sensing;Reproducibility;reproductive;Reproductive Health;Research;Research Personnel;Resources;Respondent;Running;Sampling;Sanitation;Scientist;sea level rise;Series;social;Source;Surveys;symposium;System;Time;tool;UNICEF;Vaccination;wasting;Water;webinar;Woman

PROJECT_TITLE: Integrated Demographic and Health Survey Data for Population Health Research


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: Project Narrative. Patients with Alzheimer’s disease go through years of predementia disease stages when many biological processes in the brain become progressively dysregulated. It is critical to understand this complex pathophysiology that culminates in malfunction of β-amyloid and tau proteins that are believed to cause neurodegeneration and cognitive decline. Interestingly, these proteins normally participate in the function of the brain, and hence, we aim to study if specific disruptions in the natural patterns of neural cells performance and in the vascular maintenance for their activity may be the pathology that predisposes to mishandling of proteins in the cells.

PI_NAMEs: SITNIKOVA, TATIANA  (contact)

PROGRAM_OFFICER_NAME: HSIAO, JOHN

PROJECT_TERMS: Address;Affect;Aging;Alleles;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease risk;Amyloid beta-42;Amyloid beta-Protein;Animal Model;Apolipoprotein E;Area;Attention;beta amyloid pathology;Biological Markers;Biological Process;Blood;blood oxygen level dependent;blood oxygenation level dependent response;Blood Vessels;Brain;brain cell;Brain region;Cells;Cerebrovascular Circulation;Clinical;Cognition;Cognitive;Cognitive deficits;cohort;Complex;cost effective;cost estimate;Coupling;Data;Dementia;density;Deposition;Disease;Dorsal;Early Intervention;effective therapy;Electroencephalography;Enrollment;Episodic memory;Event;executive function;Exhibits;follow-up;Functional disorder;Functional Magnetic Resonance Imaging;functional magnetic resonance imaging/electroencephalography;Future;genetic risk factor;Hematological Disease;High Prevalence;Homeostasis;Human;Image;imaging modality;Imaging Techniques;Imaging technology;Impaired cognition;in vivo;Individual;interest;invention;Investigation;Link;Longitudinal cohort;Machine Learning;Maintenance;Measurement;Measures;Mediating;Memory;Metabolic;Metabolism;Methods;mild cognitive impairment;Multivariate Analysis;Nerve Degeneration;neural;neural network;neural patterning;Neurodegenerative Disorders;Neurofibrillary Tangles;Neurons;neurophysiology;Neurophysiology - biologic function;neurovascular;neurovascular coupling;novel;older adult;Pathologic;Pathology;Patients;Performance;pharmacologic;Physiological;Population;Predisposition;prevent;Preventive therapy;Process;Property;Proteins;Public Health;Records;Recurrence;Regional Disease;Regulation;Reporting;response;Rest;Scanning;Senile Plaques;Signal Transduction;source localization;Structure;Symptoms;System;tau Proteins;Techniques;Technology;Testing;Time;Work

PROJECT_TITLE: Simultaneous EEG/fMRI to disentangle neural and vascular mechanisms of Alzheimer's disease pathology


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Genetics;Orphan Drug;Pancreatic Cancer;Precision Medicine;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_DEPT: SURGERY

ORG_NAME: THOMAS JEFFERSON UNIVERSITY

ORG_STATE: PA

PHR: PROJECT NARRATIVE Tumor heterogeneity and limited chemotherapeutic efficacy in pancreatic ductal adenocarcinoma underscores the need to find new targets and molecular interactions for PDAC diagnosis and therapy. In this proposal, we will determine the molecular interaction between a DNA repair protein, BARD1 and a cell cycle regulator, PLK- 1 using biochemical assays and determine if this interaction plays a role in regulating therapeutic efficacy of PARP inhibitors and platinums. Completion of this project would advance our understanding of pancreatic ductal adenocarcinoma and provide new possibilities for targeted therapeutic interventions.

PI_NAMEs: JAIN, ADITI  (contact)

PROGRAM_OFFICER_NAME: SHARMAN, ANU

PROJECT_TERMS: acquired drug resistance;Affect;Animal Model;BARD1 gene;Binding;Biochemical;Biological Assay;brca gene;BRCA mutations;BRCA1 gene;cancer therapy;cancer type;cdc Genes;Cell Aging;Cell Cycle;Cell Cycle Progression;Cell Cycle Proteins;Cell Cycle Regulation;Cell Line;Cell Physiology;Cell Proliferation;Cells;Clinic;Clinical;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;conventional therapy;Critical Pathways;Data;Defect;design;Development;Diagnosis;Disease;DNA biosynthesis;DNA Damage;DNA Repair;DNA Repair Gene;Drug Combinations;drug development;effective therapy;experimental study;Future;Genetic;Genetic Heterogeneity;Goals;Growth;homologous recombination;homologous recombination deficiency;In Vitro;in vivo;inhibitor;inhibitor therapy;knock-down;Link;Malignant neoplasm of pancreas;Malignant Neoplasms;Mitosis;Molecular;mouse model;new therapeutic target;novel therapeutic intervention;novel therapeutics;Oncogenic;overexpression;oxaliplatin;PALB2 gene;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;patient population;Patients;personalized medicine;Pharmaceutical Preparations;Phenotype;Phosphorylation;Platinum;Play;pleiotropism;PLK1 gene;Poly(ADP-ribose) Polymerase Inhibitor;Polymerase;Predisposition;Prognosis;Property;Protein-Serine-Threonine Kinases;Proteins;Publishing;recombinational repair;Regulation;response;Role;success;Survival Rate;synergism;System;targeted treatment;Testing;Therapeutic Effect;Therapeutic Intervention;therapy resistant;Toxic effect;transcriptomic profiling;Treatment Efficacy;treatment response;Treatment-related toxicity;tumor;tumor growth;tumor heterogeneity;tumorigenesis;Up-Regulation

PROJECT_TITLE: Elucidating the relevance of BARD1-PLK1 interaction in PDAC and response to therapy


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Digestive Diseases;Infectious Diseases;Microbiome;Neurodegenerative;Neurosciences

ORG_CITY: HOUSTON

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: Alzheimer’s Disease is a significant threat to public health as it is the only one of the top 10 causes of death in the United States that cannot be effectively prevented, treated, or cured. This proposal aims to determine if infections due to fungi and bacteria can be implicated as causes of Alzheimer’s Disease and involves creating a mouse model of gut yeast infection that then spreads to the brain to cause Alzheimer’s-like disease. Success with creating this new model will allow us to further understand how Alzheimer’s Disease progresses and how to diagnose and treat this devastating illness.

PI_NAMEs: BIMLER, LYNN  (contact)

PROGRAM_OFFICER_NAME: HAAKENSON, CHELSEA MARIE

PROJECT_TERMS: 16S ribosomal RNA sequencing;Affect;Alleles;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease therapeutic;Amyloid beta-Protein;Amyloid beta-Protein Precursor;anti-fungal agents;Anxiety;apolipoprotein E-4;Aspartic Endopeptidases;Bacteria;Bacterial Adhesins;Behavior;behavior test;Biological Response Modifiers;Blocking Antibodies;Blood - brain barrier anatomy;Blood Circulation;blood-brain barrier penetration;Brain;brain size;C57BL/6 Mouse;Candida albicans;candidemia;Cause of Death;Cells;Cerebrum;Characteristics;Chronic;cognitive function;Complement;cytokine;Data;Dementia;Deposition;Development;Diagnosis;Disease;disease phenotype;Dose;Enteritis;Enterobacteriaceae;Enzyme-Linked Immunosorbent Assay;Filament;Fright;fungus;Gastritis;Gastrointestinal tract structure;Genes;Genotype;Genus staphylococcus;Granuloma;gut bacteria;gut colonization;gut inflammation;Harvest;Histologic;Histology;Human;Immune;Immune Evasion;Immune response;Infection;Inflammatory;Interferons;Intestines;Intravenous;intravenous administration;Invaded;Link;Lytic;Memory impairment;Memory Loss;migration;Modeling;Monitor;Morphology;mouse model;Mus;mutant;Neoplasm Metastasis;Neurofibrillary Tangles;Neuroimmune;Neuroimmunomodulation;Neurologic Dysfunctions;novel;Oral;Pathogenesis;Pathogenicity;Pathologic;Peptides;Physiological;prevent;Proteolysis;Proteome;Public Health;Publishing;Recurrence;Research;response;Role;Sampling;Senile Plaques;Site;stool sample;Structure;success;Surface;synthetic polymer Bioplex;tau-1;Tauopathies;Testing;Tissues;Toxin;Transgenic Mice;translational model;transmission process;United States;Virulence Factors;Western Blotting;yeast infection;Yeasts

PROJECT_TITLE: Chronic Murine Cerebral Mycosis: Pathogenesis, Neuroimmune Response, and Relevance to Alzheimer's Disease

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development For Early Career Investigators Study Section [AGCD-2]


PHR: Narrative Molecular mechanisms regulating B cell maturation and activation are essential for function of the immune system. Here we will study the role of ubiquitin E3 ligase, UBR5 and the spliceosome during B cell maturation. Deciphering role of UBR5 in B cell development and provide clues to novel pathways regulating immunity.

PI_NAMEs: BUCKLEY, SHANNON  (contact)

PROGRAM_OFFICER_NAME: CASTLEMAN, MORIAH JOVITA

PROJECT_TERMS: adaptive immunity;Alternative Splicing;Antibodies;B-Cell Activation;B-Cell Development;B-Lymphocyte Subsets;B-Lymphocytes;C-terminal;Cell Cycle;Cell Maturation;cell motility;Cell Physiology;Cells;Complex;conditional mutant;Cysteine;Data;Defect;Development;DNA Damage;DNA Repair;Down-Regulation;Genetic;Genetic Transcription;Goals;Hematopoietic Neoplasms;Immune system;immune system function;Immunity;immunodeficiency;Immunoglobulin Class Switching;Immunoglobulin D;Immunoglobulin Somatic Hypermutation;Immunoglobulin Switch Recombination;Immunologic Stimulation;Immunoprecipitation;improved;insight;Length;leukemia/lymphoma;Ligase;Lymphomagenesis;Lymphopoiesis;Malignant Neoplasms;Mantle Cell Lymphoma;Mediating;Messenger RNA;Molecular;mutant;Mutant Strains Mice;Mutate;Natural Immunity;novel;overexpression;Pathway interactions;Patients;peripheral blood;Phenotype;plasma cell differentiation;Plasma Cells;Play;Population;Process;protein expression;Proteins;Proteomics;PTPRC gene;Regulation;RNA Splicing;Role;scaffold;Signal Pathway;Signal Transduction;Spleen;Spliceosomes;Structure of germinal center of lymph node;Testing;tool;Transcript;Transcriptional Regulation;Translations;tumor;Ubiquitin;ubiquitin ligase;ubiquitin-protein ligase;Up-Regulation;V(D)J Recombination;Variant

PROJECT_TITLE: Role of E3 Ligase UBR5 in Alternative Splicing during B Cell Development and Activation

STUDY_SECTION: CMIB

STUDY_SECTION_NAME: Cellular and Molecular Immunology - B Study Section[CMIB]


ORG_CITY: SHREVEPORT

ORG_NAME: LOUISIANA STATE UNIV HSC SHREVEPORT

ORG_STATE: LA

PHR: This project investigates how human cytomegalovirus (HCMV) cloaks itself in a “sugar shield” to escape from antibodies and other immune defenses. HCMV causes life-threatening opportunistic infections in immune compromised people and is the #1 viral cause of birth defects that lead to permanent hearing loss and other neurodevelopmental disabilities in young children. The studies proposed in this project will generate new information that can be harnessed toward the development of effective vaccines and therapies against HCMV and other persistent enveloped viruses.

PI_NAMEs: KAMIL, JEREMY PHILLIP (contact)

PROGRAM_OFFICER_NAME: GAUTAM, RAJEEV

PROJECT_TERMS: 3-Dimensional;acute infection;adaptive immunity;Address;Amino Acids;analog;Antibodies;Antibody Response;Antibody titer measurement;Antigens;Binding;Binding Proteins;Biogenesis;Biological;biological adaptation to stress;Biological Process;Carbohydrates;cell type;Cells;Cellular Stress;Charge;Child;chronic infection;Complex;Congenital Abnormality;congenital infection;Consensus;Cysteine;Cytomegalovirus;Cytomegalovirus Infections;Cytomegalovirus Vaccines;Data;Development;DNA Viruses;Endothelial Cells;env Gene Products;Environment;Enzymes;Epithelial Cells;Epithelium;Exhibits;Fabaceae;Fibroblasts;Generations;Genes;Genetic;genetic approach;Glycobiology;Glycocalyx;Glycoproteins;glycosylation;Goals;Herpesviridae;Homologous Gene;Human;Immune;Immune Evasion;Immune response;Immunity;Immunize;immunodeficiency;immunogenicity;Immunoglobulins;Infection;Ions;Knowledge;Lectin;Life;Link;Lymphocyte;Malignant Neoplasms;Maps;Mass Spectrum Analysis;Measures;Mediating;Membrane;Membrane Proteins;Messenger RNA;Metals;Modification;Molecular;mouse model;Mus;Mutagenesis;mutant;Mutation;Neuraminidase;Neurodevelopmental Disability;Neuropilin-2;Neutralization Tests;neutralizing antibody;Neutralizing antibody assay;nonhuman primate;Oligosaccharides;Opportunistic Infections;Orthologous Gene;Pathway interactions;Patients;Pattern;permanent hearing loss;Persons;pharmacologic;Platelet-Derived Growth Factor alpha Receptor;Play;polyclonal antibody;Polysaccharides;prevent;Production;programs;Protein Glycosylation;protein structure;Proteins;Proteomics;Quality Control;Reagent;receptor;Recombinants;Research;Resistance;response;Role;sialic acid binding Ig-like lectin;Sialic Acids;sialylation;Sialyltransferases;Structural Models;Structure;sugar;Surface;Testing;Tissues;treatment strategy;Tropism;vaccination strategy;Vaccines;Viral;Viral Envelope Proteins;Viral Proteins;Virion;Virus;virus host interaction

PROJECT_TITLE: Roles of the UL148 glycoprotein in human cytomegalovirus infection

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IIDA-G(02)]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology;Genetics;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: NEW YORK

ORG_DEPT: PATHOLOGY

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: NARRATIVE When cells mature or respond to changes in their environment, they turn on some genes, turn off others, and destroy gene products that are no longer needed. When this process goes awry, cancer and other diseases can occur. This proposal focuses on identifying how cells destroy two classes of gene products—microRNAs and circular RNAs—that are important for controlling the expression of other genes.

PI_NAMEs: KLEAVELAND, BENJAMIN MONTEVERDE (contact)

PROGRAM_OFFICER_NAME: CZAPLINSKI, KEVIN

PROJECT_TERMS: Area;Binding;Binding Sites;Cell Line;cell type;Cells;Child;circular RNA;cis acting element;Code;Complex;Dedications;Development;Disease;Engineering;Environment;Gene Expression;gene product;Genes;genome-wide;improved;infancy;Knowledge;Malignant Neoplasms;Mediating;MicroRNAs;Modeling;Molecular Biology Techniques;multicatalytic endopeptidase complex;Neurons;Organism;Outcome;Pathway interactions;Postdoctoral Fellow;posters;posttranscriptional;Process;Production;Proteins;recruit;Regulation;Regulator Genes;Research;Resistance;response;RNA;Role;Site;Slice;Stimulus;Synaptic Vesicles;Transgenic Mice;ubiquitin-protein ligase;Ubiquitination;Untranslated RNA;vesicular release;Viral;Work

PROJECT_TITLE: Destruction of noncoding RNAs

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


ADMINISTERING_IC: AA

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Substance Misuse

ORG_CITY: ALBUQUERQUE

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF NEW MEXICO

ORG_STATE: NM

PHR: PROJECT NARRATIVE This early career development grant includes training in alcohol use disorder recovery research, advanced quantitative methods, and professional development by a strong mentoring team to help the principal investigator transition to an independent investigator in the alcohol field. The proposed research examines recovery from alcohol use disorder as defined by NIAAA from the perspectives of self-determination theory and behavioral economics by leveraging two periods of voluntary temporary abstinence. Training and research activities are carefully sequenced to maximize knowledge gains.

PI_NAMEs: RICHARDS, DYLAN K (contact)

PROGRAM_OFFICER_NAME: HAGMAN, BRETT THOMAS

PROJECT_TERMS: Abstinence;Adult;alcohol abstinence;Alcohol consumption;alcohol free;alcohol use disorder;Alcohols;Area;Behavior;behavior change;behavioral economics;Behavioral Mechanisms;biopsychosocial;career development;clinical practice;cohort;Costs and Benefits;craving;Decision Making;design;Development;Disease remission;Disparate;drinking;Dryness;DSM-V;ethnic difference;ethnic diversity;Ethnic Origin;Facebook;follow up assessment;Goals;Grant;hazardous drinking;Heavy Drinking;improved;Individual;innovation;Intervention;Knowledge;Literature;Longitudinal, observational study;Mentors;Methodology;Methods;Motivation;National Institute on Alcohol Abuse and Alcoholism;novel;Participant;Patient Care;Personal Satisfaction;Persons;Population;Postdoctoral Fellow;precision medicine;preference;Principal Investigator;Process;prospective;Prospective Studies;psychologic;Public Health;Publishing;Quality of life;racial difference;racial diversity;Recovery;recruit;reinforcer;Research;Research Activity;Research Design;Research Personnel;Sampling;Self Determination;Self Direction;Self Efficacy;sex;Sex Differences;skills;sobriety;Surveys;sustained recovery;Symptoms;Testing;theories;TikTok;Training;Training Activity;training opportunity

PROJECT_TITLE: Understanding recovery from alcohol use disorder: Longitudinal observation of two voluntary temporary abstinence periods

STUDY_SECTION: AA

STUDY_SECTION_NAME: Clinical, Treatment and Health Services Research Study Section[AA-3]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: LEXINGTON

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: PROJECT NARRATIVE Obesity is paradoxically associated with improved survival during sepsis and other critical illnesses; however, the mechanistic basis for this protection is not understood. This project will investigate whether circulating lipids, which are elevated in the obese, are associated with improved outcomes in sepsis patients. The obtained data will allow for future mechanistic studies to further understand the processes at play.

PI_NAMEs: SHRIDAS, PREETHA ;STARR, MARLENE ELENA (contact)

PROGRAM_OFFICER_NAME: ZHOU, GUOFEI

PROJECT_TERMS: Abbreviations;Acceleration;Acute;Acute Lung Injury;Acute-Phase Proteins;Adipose tissue;anorexic;Biological;Biological Specimen Banks;Body mass index;Carbohydrates;Cardiovascular Diseases;Categories;Characteristics;Cholesterol;Citric Acid Cycle;Clinical;Clinical Data;Clinical Research;Clinical Trials;Critical Illness;Data;data repository;Development;diet-induced obesity;Energy Supply;Energy-Generating Resources;Fatty Acids;Fever;Functional disorder;Funding Opportunities;Future;Glucose;Goals;healthy weight;Human;Human Biology;human disease;immune activation;Impairment;improved;improved outcome;Inflammation;Ketone Bodies;Length of Stay;Life;lipid metabolism;Lipids;Lipolysis;Malignant Neoplasms;Measures;Mediating;Medical;Metabolic;Mission;Modeling;mortality;mouse model;National Heart, Lung, and Blood Institute;Non-Insulin-Dependent Diabetes Mellitus;Nonesterified Fatty Acids;novel therapeutic intervention;Obese Mice;Obesity;Organ;Outcome;Pathology;Pathway interactions;Patients;Phagocytosis;Pharmaceutical Preparations;Physiological;Placebos;Plasma;Play;pre-clinical;Process;Production;protective effect;Proteins;Recommendation;Reporting;Research;response;Risk Factors;Role;rosuvastatin;Sampling;Science;Sepsis;septic;septic patients;Tachycardia;therapeutic development;Therapeutic Intervention;translational potential;Translational Research;treatment group;Triglycerides;Up-Regulation;Work

PROJECT_TITLE: The Role of Lipids in Obesity-mediated Protection in Sepsis


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: Project Narrative Previous studies of eosinophils, which are white blood cells that contribute to the regulation of immunity, have historically focused on allergic responses and parasitic helminth infections, and are found to be associated with type II inflammatory settings. However, our understanding of the role of eosinophils in persistent bacterial infections is incomplete. In this application, we will elucidate mechanisms of eosinophil control of persisting Salmonella within systemic granulomas, which will provide new insights into how to treat and irradicate chronic intracellular bacterial infections.

PI_NAMEs: MONACK, DENISE M (contact)

PROGRAM_OFFICER_NAME: ALEXANDER, WILLIAM A

PROJECT_TERMS: Acute;Affect;allergic response;Anti-Bacterial Agents;antimicrobial;Antimicrobial Effect;B-Lymphocytes;Bacteria;Bacterial Infections;bactericide;Biochemical;CCL11 gene;Cells;chemokine;Chemotactic Factors;Chronic;chronic infection;Citrobacter rodentium;Complex;Cues;Cytoplasmic Granules;Data;Disease;DNA;Environment;eosinophil;Eotaxin;extracellular;Future;Gastroenteritis;Genetic;Goals;Granuloma;Growth;Health;Helicobacter pylori;helminth infection;Helminths;Homeostasis;Host resistance;Hypersensitivity;IgG2;Immune;Immune response;Immunity;immunoregulation;in vivo;Infection;Infectious granuloma;Inflammatory;insight;Interferon Type II;Knowledge;Leukocytes;Lung;Macrophage;mesenteric lymph node;Modeling;Mus;Mycobacterium tuberculosis;nonhuman primate;Oranges;pathogen;pathogenic bacteria;Patients;persistent bacterial infection;pharmacologic;Phase;Predisposition;Preventive;Production;Property;Proteins;Pseudomonas aeruginosa;Publishing;Regulation;Reporting;response;Role;Salmonella;Salmonella enterica;Salmonella infections;Salmonella typhimurium;Staphylococcus aureus;Stomach;Systemic infection;T-Lymphocyte;T-Lymphocyte Subsets;Testing;Therapeutic;Tissues;Tuberculosis;tuberculosis granuloma;Typhoid Fever;Virulence Factors;Virus;wound healing

PROJECT_TITLE: Role of eosinophils during bacterial infection

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IIDB-K(90)]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Neurosciences;Pain Research;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: The goal of these studies is to understand how nerves in the nasal epithelium may detect fungal allergens and interact with other cells to initiate allergic inflammation. We think that nerves become activated by fungal allergens and secrete specific proteins that cause specialized cells in the epithelium to proliferate and initiate the early stages of inflammation. We also think that both neurons and inflammation worsen sneezing.

PI_NAMEs: HERBERT, DE'BROSKI R (contact);ROSSI, HEATHER L

PROGRAM_OFFICER_NAME: DONG, GANG

PROJECT_TERMS: Ablation;Address;Adrenal Cortex Hormones;Affect;Afferent Neurons;airway epithelium;Allergens;Allergic;Allergic Disease;Allergic inflammation;Alternaria;analog;Aspergillus fumigatus;associated symptom;Automobile Driving;Basal Cell;Behavior;Bone Marrow;Capsaicin;Cell Differentiation process;Cell Lineage;Cell secretion;cell type;Cells;Characteristics;Chimera organism;Chronic;chronic rhinosinusitis;clinically relevant;Cre driver;Curiosities;cysteinyl-leukotriene;cytokine;cytotoxic;Data;Development;Disease;Ensure;eosinophil;Eosinophilia;Epithelial Cells;Epithelium;Evaluation;Excision;Exposure to;Facial Pain;Feedback;Functional disorder;Genetic;Goals;healthcare burden;high reward;high risk;Immune;Inflammation;Inflammatory;Inflammatory Response;Innate Immune Response;insight;Interleukins;Intranasal Administration;Knowledge;Liquid substance;loss of function;Lymphoid Cell;Macrophage;Mediator;Modeling;Molecular;mouse model;Mucous body substance;Mucous Membrane;Mus;Nasal cavity;Nasal Epithelium;Nerve;Neuroglia;Neuroimmune;Neurons;Neuropeptides;new therapeutic target;Nociceptors;novel;Operative Surgical Procedures;Outcome;Patients;Peptide Initiation Factors;Population;postmitotic;Process;Proliferating;Proteins;Proteolysis;Quality of life;receptor;recruit;Regulation;release factor;Resistance;response;rhinosinusitis;Role;Signal Transduction;single-cell RNA sequencing;Sneezing;Specialized Epithelial Cell;stem cell expansion;stem cells;Structure of trigeminal ganglion;Substance P;TACR1 gene;Testing;therapeutic target;Tissues;transcriptome;Transgenic Mice;Trigeminal System;TRPV channel;TRPV1 gene;Vanilloid

PROJECT_TITLE: Neuronal regulation of sinonasal Type 2 inflammation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-RCCS-B(03)]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Brain Disorders;Genetics;Human Genome;Mental Health;Neurosciences;Pediatric;Schizophrenia;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: ATLANTA

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE The schizophrenia-associated copy number variants 3q29 deletion and 22q11.2 deletion produce strikingly similar clinical phenotypes, but it is not known whether these high-risk alleles have convergent effects at cellular and molecular levels. Our studies strongly indicate that 3q29 deletion produces mitochondrial phenotypes in the central nervous system, which aligns with previous reports of mitochondrial phenotypes in 22q11.2 deletion. This career development project is aimed at understanding the extent of these phenotypes in genetically controlled human iPSC and mouse experimental model systems, with the goal of testing the hypothesis of phenotypic convergence at mitochondria.

PI_NAMEs: PURCELL, RYAN HERNDON (contact)

PROGRAM_OFFICER_NAME: DRISCOLL, JAMIE DANIELLE

PROJECT_TERMS: 22q11;22q11.2;3q29;Address;Alleles;Astrocytes;Biological;Biological Assay;Biological Models;Biology;biomarker panel;Brain;career development;Cell Line;Cell Respiration;Cells;Central Nervous System;clinical phenotype;cohort;comparison control;Complex;Copy Number Polymorphism;Data;design;differential expression;Disease;disorder risk;Engineering;experience;Experimental Models;experimental study;Female;Flow Cytometry;Formulation;Foundations;Future;Galactose;Genes;Genetic;genomic locus;Genus Hippocampus;Glycolysis;Goals;high risk;Human;Human Cell Line;human induced pluripotent stem cells;Immunofluorescence Immunologic;Impairment;induced pluripotent stem cell;knock-down;Lentivirus;Link;male;Measures;media use;Mentors;Metabolic;Metabolic stress;Mitochondria;Mitochondrial Proteins;Modeling;Molecular;mouse model;Mus;National Institute of Mental Health;Neocortex;neonatal mice;nerve stem cell;Nervous System;neural;Neurobiology;Neurodevelopmental Disorder;neurogenesis;neuron development;Neurons;neuropsychiatry;Organoids;Oxidative Phosphorylation;Oxygen Consumption;Pathway interactions;Perinatal;Phenotype;Postdoctoral Fellow;postnatal;premature;Process;programs;Proteins;Proteome;Proteomics;psychiatric genomics;Psychiatry;psychogenetics;Reporting;Research;Research Support;Respiration;Ribosomes;risk variant;Same-sex;Schizophrenia;schizophrenia risk;screening;single-cell RNA sequencing;Site;skills;stem;stoichiometry;Stress;System;Testing;Therapeutic;Tissues;Titrations;tool;Training;transcriptomics;Validation;Work

PROJECT_TITLE: Phenotypic convergence at mitochondria in copy number variant disorders

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD]


NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Pediatric

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: The University of Colorado Rocky Mountain NeuroNEXT Clinical Research Consortium (UNCOMON CRC) comprises a large group of adult and pediatric physicians from multiple hospitals across the Rocky Mountain region who are experienced leaders in the field of clinical neuroscience. The UNCOMON CRC possesses the infrastructure, clinical research personnel, and patient population to be a leading contributor to the network and help further our understanding and advance therapies for rare and genetic neurological across the age spectrum.

PI_NAMEs: BENKE, TIMOTHY A;BENNETT, JEFFREY L (contact);PIQUET, AMANDA L

PROJECT_TERMS: Acceleration;Adult;Advocacy;Age;Algorithms;Area;Behavioral;biobank;care systems;career;Childhood;Clinic;Clinical;Clinical Protocols;Clinical Research;clinical research site;Clinical Trials;Clinical Trials Network;Colorado;Communication;community academic partnership;community engagement;Community Outreach;Contracts;Data;Databases;demographics;design;Disease;education resources;eHealth;Enrollment;Ensure;Equity;Ethics;experience;Faculty;Funding;Genetic;Geography;Goals;hospital care;Hospitals;Immunologics;Individual;Informatics;Infrastructure;Institutional Review Boards;investigator training;Leadership;Managed Care;Medical;medical specialties;Minority;Minority Groups;Monitor;Movement Disorders;Multi-Institutional Clinical Trial;Native-Born;Nervous System Disorder;neurogenetics;neuroimaging;Neurologic;Neurology;neuromuscular;Neuropsychology;Neurosciences;neurosurgery;next generation;operation;Operations Research;outreach;patient advocacy group;patient population;Patient Recruitments;Patient Representative;patient retention;Patients;pediatric department;Pediatric Hospitals;Pediatric Neurology;Pediatric Research;Physicians;Population;programs;Protocols documentation;Qualifying;Rare Diseases;Recording of previous events;recruit;Research;Research Infrastructure;Research Personnel;Research Training;Resources;Rural Population;Site;skills;Source;Specialist;support network;Therapeutic;therapeutic development;Training;Training Support;Underserved Population;Universities;Work

PROJECT_TITLE: University of Colorado Rocky Mountain NeuroNEXT (UNCOMON) Clinical Research Consortium.


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Patient Safety;Physical Injury - Accidents and Adverse Effects;Prevention;Rehabilitation

ORG_CITY: TUCSON

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: Falls are a leading cause of injury and death and every year, nearly 25-50% of older adults fall. The vestibular system, part of the inner ear, is a known contributor to fall risk; however, recent evidence suggests that cognition and vestibular function may interact to contribute to falls as almost 2 out of 3 patients with Alzheimer’s disease (AD) fall and those with vestibular function exhibit changes in cognition. In this study, we will investigate multiple domains of vestibular function, cognition, and sensorimotor behaviors in patients with AD and vestibular loss to further understanding of mechanisms contributing to falls.

PI_NAMEs: KOBEL, MEGAN  (contact)

PROGRAM_OFFICER_NAME: RIVERA-RENTAS, ALBERTO L

PROJECT_TERMS: Address;Adult;Aging;aging population;Alzheimer's Disease;Alzheimer's disease patient;Area;Award;Behavior;Biological Assay;Cessation of life;Clinical;clinical practice;Cognition;Cognitive;cognitive function;Data;Development;diagnostic strategy;Disease;Equilibrium;Exhibits;experience;Eye Movements;Fall prevention;fall risk;falls;Foundations;functional outcomes;Future;Gait;Goals;Health;Impaired cognition;improved;Individual;Injury;insight;Intervention;Investments;Laboratories;Labyrinth;Link;Measures;Medical Care Costs;Mentored Research Scientist Development Award;Mentorship;Methodology;Motion Perception;Musculoskeletal Equilibrium;National Institute on Deafness and Other Communication Disorders;Neural Pathways;novel;Ohio;older adult;Organ;otoconia;Pathogenesis;Pathology;Pathway interactions;patient population;Patients;Perception;Performance;Peripheral;Physiology;Prevalence;Prevention;preventive intervention;Recording of previous events;Research;Research Personnel;Role;Science;Sensory;Strategic Planning;Structure;System;Techniques;Training;Training Activity;Translational Research;United States;Universities;Vestibular dysfunction;Vestibular function;Vestibular loss;vestibular reflex;vestibular system;visual-vestibular;Work

PROJECT_TITLE: Elucidating links between vestibular function, cognition, and sensorimotor behavior

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Dissemination and Implementation Research;Lung;Rare Diseases

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE There is incomplete penetration of proven-effective, evidence-based practices for the nearly 1 million Americans experiencing acute respiratory failure (ARF) every year. Empirical evidence to guide selection of implementation strategies with the greatest potential impact in critical care settings is urgently needed. This study will demonstrate how established multilevel modeling techniques can be used in innovative ways to analyze existing multicenter datasets to inform selection of implementation strategies for patients with ARF and evaluate their effectiveness.

PI_NAMEs: TURNBULL, ALISON  (contact)

PROGRAM_OFFICER_NAME: POSTOW, LISA

PROJECT_TERMS: acute care;Acute Respiratory Distress Syndrome;Acute respiratory failure;Address;Adherence;Adoption;American;Biostatistical Methods;Characteristics;clinical epidemiology;clinical practice;Clinical Research;Cohort Studies;Complex;concept mapping;Consolidated Framework for Implementation Research;Critical Care;Data;Data Set;Dedications;design;Disease;effective intervention;Effectiveness;Electronic Health Record;Environmental Risk Factor;Epidemiologic Methods;Evaluation;Evidence based practice;Evidence based treatment;experience;Funding;Goals;Health;Hospitals;implementation evaluation;implementation research;implementation science;implementation strategy;improved;Individual;innovation;Intensive Care Units;Intervention;Intubation;Knowledge;Life;Maps;Masks;Measures;Mechanical ventilation;Modeling;Motivation;multilevel analysis;Organizational Culture;Outpatients;Patient Care;patient population;Patients;Penetration;Phase;preference;prevent;Process;programs;provider factors;Qualitative Methods;randomized trial;recruit;Research Personnel;Resources;response;SET Domain;stakeholder perspectives;standard of care;success;Techniques;Tidal Volume;treatment comparison;uptake;Variant;Vent;ventilation;Work

PROJECT_TITLE: Strengthening implementation science in Acute Respiratory Failure using multilevel analysis of existing data

STUDY_SECTION: SIHH

STUDY_SECTION_NAME: Science of Implementation in Health and Healthcare Study Section[SIHH]


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;HIV/AIDS;Hepatitis;Hepatitis - B;Infectious Diseases;Liver Disease

ORG_DEPT: PEDIATRICS

PHR: Project Narrative HIV co-infection accelerates liver cirrhosis and liver cancer in chronic hepatitis B virus (HBV) carriers. Our proposed work will establish robust and physiologically relevant primary cell culture systems to study HIV/HBV co-infections. These systems will provide a platform to develop novel antiviral strategies that may lead to a functional HBV cure.

PI_NAMEs: MICHAILIDIS, ELEFTHERIOS  (contact)

PROGRAM_OFFICER_NAME: RADKE, JOSHUA BRYAN

PROJECT_TERMS: 3-Dimensional;Acceleration;Affect;Antigens;antiretroviral therapy;Area;biomarker identification;CD4 Positive T Lymphocytes;Cell Culture System;Cell Line;Cell Separation;Cells;Chronic;Chronic Hepatitis B;chronic infection;Circular DNA;co-infection;Coculture Techniques;curative treatments;Detection;drug development;drug resistance development;e Antigens;Exhibits;Genetic Transcription;Goals;Health;Hepatitis B Infection;Hepatitis B Surface Antigens;Hepatitis B Vaccines;Hepatitis B Virus;Hepatocyte;hepatoma cell;high risk;HIV;HIV Infections;Human;humanized mouse;Immune response;In Vitro;Individual;Infection;innovation;insight;Interferon alpha;Investigation;Knowledge;Life;Life Cycle Stages;Link;Liver;Liver Cirrhosis;Liver diseases;Maintenance;Malignant neoplasm of liver;Measurement;Messenger RNA;Modeling;Mus;Nature;novel;Nuclear;nucleoside analog;overexpression;Patients;Persons;Physiological;predictive marker;Primary carcinoma of the liver cells;Primary Cell Cultures;prophylactic;Research;response;Risk;RNA;RNA-Directed DNA Polymerase;spheroids;System;Time;transcriptome;transcriptome sequencing;transcriptomics;Viral;Viral Genome;viral rebound;Virus;virus core;Virus Diseases;Virus Receptors;Virus Replication;Withholding Treatment;Work

PROJECT_TITLE: Primary cell culture models of HIV/HBV co-infection

STUDY_SECTION: HCAC

STUDY_SECTION_NAME: HIV Coinfections and HIV Associated Cancers Study Section[HCAC]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cardiovascular;Clinical Research;Emergency Care;Health Services;Heart Disease;Lung;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Project Narrative Since the start of the pandemic, patients, including very sick heart failure patients, are having to remain in the Emergency Department for hours or even days longer than necessary because there are no beds available in the wards where they need transfer for specialized treatment. Emergency physicians need new tools that help them keep up with these ever increasing demands on their time and attention. The novel tools proposed in this grant could help Emergency Department physicians rapidly re-examine heart failure patients every few hours, assess improvements in their lungs, and adjust their treatment as needed.

PI_NAMEs: GOLDSMITH, ANDREW ;KAPUR, TINA  (contact)

PROGRAM_OFFICER_NAME: SHABESTARI, BEHROUZ

PROJECT_TERMS: Accident and Emergency department;Acute;Address;Admission activity;Algorithms;Attention;Automation;Beds;Biological Markers;Blood Tests;care outcomes;Caring;Clinical;Clinical assessments;clinical care;clinical examination;Clinical Markers;Clinical Research;Clip;cognitive load;cohort;computerized tools;Computing Methodologies;Congestive Heart Failure;Correlation Studies;COVID-19;COVID-19 pandemic;Critical Illness;Data;Decision Making;deep learning;Dependence;Detection;Devices;Diagnosis;Emergency Care;Emergency Department Physician;Etiology;Evaluation;experience;Functional disorder;Funding;Goals;Grant;Heart failure;Hospitalization;Hospitals;Hour;Human;Image;improved;inpatient service;Inpatients;Laboratories;Length;Length of Stay;Lung;Manuals;Measures;Methods;Modeling;mortality;Multi-Institutional Clinical Trial;new technology;novel;novel therapeutics;Nursing Staff;Observational Study;Outcome;pandemic disease;participant enrollment;Patient Admission;Patient Care;Patient-Focused Outcomes;Patients;Performance;Physical Examination;Physicians;point of care;prevent;prognostic value;prospective;Provider;Public Health;Recording of previous events;research study;Role;Sensitivity and Specificity;Severities;Severity of illness;skills;Specialist;Standardization;Therapeutic Intervention;Thoracic Radiography;Time;tool;Training;Ultrasonography;ultrasound;United States National Institutes of Health;Variant;ward

PROJECT_TITLE: Deep Learning Assisted Scoring of Point of Care Lung Ultrasound for Acute Decompensated Heart Failure in  the Emergency Department

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;Infectious Diseases;Prevention;Rare Diseases

ORG_CITY: GREENVILLE

ORG_NAME: EAST CAROLINA UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE Brucellosis is one of the world’s leading zoonotic diseases, and Brucella abortus, B. melitensis and B. suis strains are of additional public health concern based on their potential use as agents of biowarfare or bioterrorism. Completing the objectives of the proposed research will improve our understanding of how Brucella strains produce disease in their mammalian hosts. Such knowledge can be used for the development of improved strategies to prevent and treat brucellosis in humans.

PI_NAMEs: ROOP, ROY M (contact)

PROGRAM_OFFICER_NAME: MUKHOPADHYAY, SUMAN

PROJECT_TERMS: abortion;Animal Feed;Antibiotics;Area;AT Rich Sequence;Attenuated Vaccines;attenuation;Bacteria;Bacterial Adhesins;Bacterial Chromosomes;Bacterial Genome;Binding;Binding Sites;Biochemical;Biological Warfare;Biology;Bioterrorism;Brucella;Brucella abortus;Brucella melitensis;Brucella suis;Brucellosis;chemotherapeutic agent;ChIP-seq;chromosome conformation capture;Chronic;Consensus;Cues;Data;Defect;Development;Disease;DNA;EMSA;Fever;Filament;Fingers;fitness;Gene Expression;Gene Expression Regulation;gene repression;Gene Silencing;Genes;Genetic;genetic approach;Genetic Transcription;Genome;Genus Mycobacterium;Human;improved;Infertility;Knowledge;Laboratories;Link;Mammalian Cell;Microarray Analysis;Molecular;Mus;mutant;novel;pathogen;pathogenic bacteria;Play;prevent;promoter;Property;Proteins;Proteobacteria;Pseudomonas;Public Health;quorum sensing;Regulation;Reporting;Repression;Research;Role;Route;Salmonella;Site;Site-Directed Mutagenesis;Structure;Testing;Transcription Coactivator;Transcription Repressor;transcriptome sequencing;Type IV Secretion System Pathway;Vaccines;Vibrio;Virulence;virulence gene;Work;Zinc Fingers;Zoonoses

PROJECT_TITLE: Determining the molecular basis of  gene silencing by MucR and defining its role in Brucella virulence

STUDY_SECTION: BV

STUDY_SECTION_NAME: Bacterial Virulence Study Section [BV]


NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Precision Medicine;Psoriasis

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PROJECT NARRATIVE Despite an increasing number of therapeutic options for psoriatic arthritis (PsA), a chronic progressive inflammatory disease of the skin and musculoskeletal system affecting over half a million Americans, less than a third of patients respond to therapy. This is, in part, because PsA is studied and managed as if it were a single disease. In this proposal, we will use two unique real-world PsA cohorts to better understand clinical and genetic heterogeneity in PsA and to identify those who are more likely or less likely to respond to therapy.

PI_NAMEs: KARMACHARYA, PARAS  (contact)

PROGRAM_OFFICER_NAME: WANG, YAN Z

PROJECT_TERMS: Academic Medical Centers;Active Learning;Address;Affect;Algorithms;American;Anxiety;arthritis therapy;Artificial Intelligence;biobank;Bioinformatics;biomedical informatics;career;career development;CCL18 gene;Characteristics;Chronic;Clinical;clinical data warehouse;clinical heterogeneity;Clinical Investigator;Clinical Research;Clinical Sciences;clinical training;Clinical Trials Design;Cluster Analysis;cohort;comorbidity;Complement;Computational Science;Data;Databases;design;Development;Development Plans;Disease;Disease Progression;Disease remission;effective therapy;Electronic Health Record;Electronics;Environment;epidemiology study;experience;follow-up;Fostering;Foundations;Funding;Future;Genetic;Genetic Heterogeneity;Genetic Risk;Genetic study;Genetic Variation;Genotype;Goals;Immunology;improved;Individual;Inflammatory;innovation;Institution;instructor;International;International Classification of Disease Codes;Knowledge;Link;Longitudinal cohort;Measures;Mental Depression;Mentors;Methods;Mission;Musculoskeletal;Musculoskeletal Diseases;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;novel;Obesity;Outcome;patient oriented;patient population;patient subsets;Patients;personalized approach;personalized medicine;phenome;Phenotype;polygenic risk score;Positioning Attribute;Postdoctoral Fellow;pragmatic trial;precision medicine;Prediction of Response to Therapy;predictive marker;predictive modeling;Probability;Prognosis;prospective;Psoriatic Arthritis;Publishing;Recommendation;Records;Research;Research Personnel;Research Project Grants;research study;Resources;response;Rheumatology;Sample Size;Sampling;Severities;side effect;skills;Skin;skin disorder;Statistical Methods;Stratification Factors;Subgroup;System;Techniques;Therapeutic;Training;Translational Research;treatment responders;treatment response;treatment strategy;Work

PROJECT_TITLE: Association of Phenotypes and Genotype with Treatment Response in Psoriatic Arthritis


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Clinical Research;Physical Rehabilitation;Rehabilitation

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: PROJECT NARRATIVE As one of the most prevalent behavioral voice disorders, phonotrauma (e.g., vocal fold nodules, polyps, etc.) can have devastating impacts on an individual’s ability to function in their daily life, but it continues to be unclear what factors cause and/or perpetuate these disorders. Thus, it is vital to determine factors related to the development and recovery of phonotrauma in order to prevent and adequately treat these disorders. The goal of this research is to longitudinally assess the role that psychosocial and behavioral factors play in the development and persistence of phonotrauma in a group of high-risk individuals with the long-term objectives of improving early identification of individuals at risk for phonotrauma and reforming treatment paradigms to improve outcomes.

PI_NAMEs: TOLES, LAURA ELIZABETH (contact)

PROJECT_TERMS: Address;Adherence;Affect;Ambulatory Monitoring;Behavior;Behavioral;Benign;career;clinically relevant;cohort;college;Decision Making;Development;Diagnosis;Disease;Dose;Early identification;Emotional Stress;Equipment and supply inventories;Etiology;experience;Frequencies;Funding;Goals;Grain;high risk population;improved;improved outcome;Impulsivity;Individual;Investigation;kinematics;Knowledge;Larynx;Lesion;Life;Literature;longitudinal analysis;Measurement;Measures;Mediating;Methods;Monitor;Music;Nodule;Participant;Pathology;Patients;Pattern;Personality;Personality Assessment;Personality inventories;Personality Traits;Phase;Play;Polyps;pressure;prevent;Prevention;Procedures;Production;Prognosis;programs;prospective;psychosocial;Recommendation;Recovery;Rehabilitation therapy;Research;Research Methodology;response;Risk;Risk Assessment;risk mitigation;Risk Taking;Role;Signal Transduction;skills;Social Dominance;sound;Speed;Statistical Data Interpretation;stem;Therapeutic;Time;Training;trait;vocal cord;Voice;Voice Disorders;voice therapy;Work

PROJECT_TITLE: Longitudinal Investigation of Factors Impacting the Development and Rehabilitation of Phonotrauma


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Gene Therapy;Gene Therapy Clinical Trials;Genetics;Immunotherapy;Neurosciences;Orphan Drug;Precision Medicine;Rare Diseases

ORG_CITY: CORAL GABLES

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: PUBLIC HEALTH RELEVANCE Glioblastoma is a uniformly fatal disease afflicting over 12,000 new patients yearly with a poor prognosis despite maximal safe resection and chemoradiation. To improve outcomes, we are conducting a clinical trial using a virus to deliver gene therapy to gliomas and make them sensitive to chemotherapy. We are trying to use a novel biomarker to identify patients who would maximally benefit from this treatment.

PI_NAMEs: DE LA FUENTE, MACARENA I;SHAH, ASHISH HARISH (contact)

PROGRAM_OFFICER_NAME: OLKHANUD, PUREVDORJ BALJINNYAM

PROJECT_TERMS: Adjuvant Therapy;Adult;Aftercare;Anaplastic astrocytoma;anti-tumor immune response;Attention;Biological Products;biomarker driven;biomarker identification;Biopsy;Blood;Blood specimen;Bystander Effect;CD8-Positive T-Lymphocytes;Cell Nucleus;chemoradiation;chemotherapy;Clinical;clinical candidate;clinical translation;Clinical Trials;Complex;cytokine;Cytosine deaminase;digital;Disease;E-Selectin;efficacy evaluation;Enzyme-Linked Immunosorbent Assay;Excision;Exposure to;Flucytosine;Fluorouracil;Foundations;gene therapy;Genes;Genotype;Glioblastoma;Glioma;Goals;hazard;Immune;Immune response;Immunocompetent;Immunophenotyping;improved;improved outcome;in vivo;Infiltration;Interferon Activation;Interferon Type II;Interleukin-6;Intravenous;Isocitrate Dehydrogenase;Mediating;Modality;Modeling;mutant;mutational status;Myeloid-derived suppressor cells;Names;neoplastic cell;neuro-oncology;Normal Cell;novel marker;patient prognosis;patient stratification;patient subsets;Patients;Phase;Phase III Clinical Trials;phase III trial;Primary Brain Neoplasms;Prodrugs;Prognosis;Prognostic Marker;Progression-Free Survivals;prospective;public health relevance;randomized, clinical trials;recruit;Recurrence;Resectable;responders and non-responders;response;RNA;secondary endpoint;Serum;Single Nucleotide Polymorphism;single nucleus RNA-sequencing;standard care;standard of care;Survival Rate;T cell infiltration;T cell response;Therapeutic;Time;TNF gene;transcriptomics;Transgenes;tumor;Tumor Immunity;Untranslated RNA;vector;Viral;Virotherapy;Virus

PROJECT_TITLE: A Phase 2 biomarker driven, Study of DB107, a Retroviral Replicating Vector, Combined With 5-FC in Patients with Recurrent Glioblastoma or Anaplastic Astrocytoma


NIH_SPENDING_CATS: Coronaviruses;Emerging Infectious Diseases;Infectious Diseases;Lung

ORG_CITY: Newark

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: NARRATIVE: Lung infections affect billions of individuals and cause significant morbidity and mortality. Although lung macrophages are known to be necessary to clear infectious pathogens, our understanding of the mechanisms that regulate macrophage responses and how the activity of these cells influence subsequent infections remains poorly understood. This proposal will interrogate how infection history alters outcomes from heterologous infections via trained immunity of macrophage subsets.

PI_NAMEs: GAUSE, WILLIAM CLARK;RIVERA, AMARILIZ  (contact);SIRACUSA, MARK CHRISTOPHER

PROGRAM_OFFICER_NAME: VAZQUEZ-MALDONADO, NANCY

PROJECT_TERMS: 2019-nCoV;Address;Affect;Alveolar Macrophages;anti-fungal agents;Antigens;antimicrobial;Basic Science;Biology;Cells;Cessation of life;chronic infection;Communicable Diseases;COVID-19;COVID-19 pandemic;Data;Defect;Embryo;embryo cell;Epigenetic Process;Event;experience;Experimental Models;Exposure to;extracellular;fungus;gain of function;Gene Targeting;Goals;Health;helminth infection;Helminths;human disease;IFNAR1 gene;Immune;Immune response;Immunity;Impairment;In Vitro;in vivo;Individual;Infection;Inflammation;innate immune function;insight;instructor;Interferons;Knowledge;Literature;loss of function;Lower Respiratory Tract Infection;Lung;Lung infections;lung pathogen;Macrophage;Maintenance;Maps;Mediating;Mediator;Memory;Modification;Molecular;monocyte;Morbidity - disease rate;mortality;mouse model;Mus;Mycoses;Natural Immunity;Nature;neutrophil;novel;Ontology;Outcome;Parasites;pathogen;pathogenic fungus;pathogenic virus;Pathway interactions;Play;Population;Primary Infection;programs;Publishing;pulmonary function;Recording of previous events;recruit;response;Role;Shapes;Signal Transduction;Specificity;Standardization;STAT1 gene;Stimulus;Testing;Therapeutic;tissue injury;Tissue Preservation;Tissues;Training;transcriptome;Viral;Virus;Virus Diseases

PROJECT_TITLE: The role of pathogen-experienced macrophage subsets in mediating lung immunity and heterologous protection


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Immunotherapy;Women's Health Research

ORG_CITY: INDIANAPOLIS

ORG_DEPT: GENETICS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Project Narrative Cancer immunotherapy makes great potential as a valid approach for cancers with no or limited specific targeted therapies. We identified MAL2 reduces antigen presentation and promotes immune evasion in triple negative breast cancer. We propose that targeting tumor antigen presentation is a feasible approach to enhance the efficacy of breast cancer immunotherapy.

PI_NAMEs: ZHANG, XINNA  (contact)

PROGRAM_OFFICER_NAME: SINGH, ANJU

PROJECT_TERMS: anti-PD-1;anti-tumor immune response;Antibodies;antigen binding;Antigen Presentation;Antigen Presentation Pathway;Antigen-Presenting Cells;Antigens;antitumor effect;Apoptosis;Architecture;Autologous;Binding;Bioinformatics;Breast Cancer Cell;Breast Cancer Model;Breast Cancer therapy;Cancer Biology;cancer cell;cancer genomics;cancer immunotherapy;cancer type;CD8-Positive T-Lymphocytes;cell mediated immune response;Cell membrane;Cells;Clathrin;Clinic;Clinical;Coculture Techniques;Complex;cytotoxic CD8 T cells;Cytotoxic T-Lymphocytes;cytotoxicity;Databases;Development;Docking;Down-Regulation;Endocytosis;Endocytosis Inhibition;Endocytosis Pathway;Endosomes;Extracellular Domain;Genes;Human;Immune;immune cell infiltrate;immune checkpoint blockade;Immune Evasion;Immune response;Immune system;Immunocompetent;Immunologic Surveillance;Immunology;Immunotherapy;improved;in silico;Infiltration;inhibitor;Lead;Major Histocompatibility Complex;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Neoplasms;Mediating;Membrane Proteins;Monoclonal Antibodies;Mus;Mutation;Natural Killer Cells;neoplastic cell;Organoids;Pathway interactions;Patients;PIK3CG gene;Play;Pre-Clinical Model;preclinical study;Predisposition;preservation;Process;Proteins;Protocols documentation;Reaction;Research Personnel;response;Role;Standardization;T-Lymphocyte;targeted treatment;Testing;Therapeutic;triple-negative invasive breast carcinoma;tumor;Tumor Antigens;tumor growth;tumor initiation;tumor microenvironment;Tumor Tissue

PROJECT_TITLE: Targeting MAL2-mediated endocytosis to enhance tumor cell antigen presentation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-TIR-W(01)Q]


NIH_SPENDING_CATS: Cancer

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

ORG_STATE: NY

PHR: PROJECT NARRATIVE Building on the laboratory’s longstanding interest in cancer metabolism, this project will examine the central role that mitochondria play in the regulation of nitrogen metabolism during cancer cell growth. The ability of mitochondria to generate a pool of glutamate from either glutamine or ammonia and utilize that glutamate for amino acid, glutathione, and polyamine biosynthesis will be analyzed. The insights gained will help shape new diagnostic and therapeutic strategies that exploit oncogene- and tumor suppressor-induced changes in tumor metabolism.

PI_NAMEs: THOMPSON, CRAIG B (contact)

PROGRAM_OFFICER_NAME: WILLIS, KRISTINE AMALEE

PROJECT_TERMS: aerobic glycolysis;Amino Acids;aminoacid biosynthesis;Ammonia;Anabolism;Aspartate;Avidity;cancer cell;Cancer Cell Growth;cancer therapy;Carbon;Catabolism;cell growth;Cell Survival;Cells;Citrates;Citric Acid Cycle;Clinic;Cytosol;Diagnosis;driver mutation;extracellular;Extracellular Fluid;fatty acid biosynthesis;Generations;Glucose;Glutamates;Glutamine;Glutathione;Growth Factor;in vivo;inhibitor;insight;interest;Knowledge;Laboratories;Lipids;Malignant Neoplasms;Metabolism;Mitochondria;Mutation;neoplastic cell;Nitrogen;nitrogen metabolism;novel diagnostics;novel strategies;novel therapeutic intervention;Nucleic Acids;Nucleotide Biosynthesis;Nutrient;Nutrient availability;Oncogenes;Oncogenic;Oxidative Phosphorylation;Play;Polyamines;Process;Production;Protein Biosynthesis;Regulation;Role;Shapes;success;Testing;Time;Translations;tumor;tumor metabolism;tumor microenvironment;Tumor Suppressor Proteins;uptake;Warburg Effect

PROJECT_TITLE: Exploring the Role of Nitrogen Metabolism in Cancer


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases;Prevention;Rare Diseases;Vector-Borne Diseases

ORG_CITY: BLACKSBURG

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

ORG_STATE: VA

PHR: Project Narrative Aedes aegpyti is a major vector of dengue, Zika, and chikungunya. We explore the sex- determination pathway and the sex-determining locus to develop new ways to separate the non- biting males from females to help control mosquito-borne infectious diseases.

PI_NAMEs: TU, ZHIJIAN JAKE (contact)

PROGRAM_OFFICER_NAME: COSTERO-SAINT DENIS, ADRIANA

PROJECT_TERMS: Aedes;Antibiotics;autosome;Binding;Biological;Biological Assay;Biology;Blood;Catalytic Domain;chikungunya;Chikungunya virus;Chromosomes;Code;Complex;Culicidae;Dengue;Dengue Vaccine;Dengue Virus;Development;disease transmission;disorder control;Distant;dsRNA adenosine deaminase;Engineering;Evolution;experimental study;Eye Color;Female;Flying body movement;Foundations;Future;Genes;genetic approach;genetic resource;Genome;genomic locus;Haplotypes;high throughput screening;Immunoprecipitation;improved;innovation;Insecticide Resistance;insight;intein;interest;Introns;Knock-out;Knowledge;Laboratories;Link;Maintenance;male;Mediating;Methods;Minor Lymphocyte Stimulatory Loci;Modeling;Mosquito Control;Mosquito-borne infectious disease;mRNA Precursor;Myosin Heavy Chains;Nonmuscle Myosin Type IIA;novel;Organism;pathogen;Pathway interactions;permissiveness;phenotypic biomarker;Population;Prevention;Production;programs;Property;Proteins;rational design;Recommendation;Research;RNA;RNA Binding;RNA Editing;RNA Splicing;RNA-Binding Proteins;scale up;screening;sex;Sex Chromosomes;sex determination;Sex Differentiation;Signal Transduction;synthetic construct;Temperature;Testing;transcription factor;transcriptome sequencing;Transgenes;Translating;transmission process;Untranslated RNA;vector;vector control;Vector-transmitted infectious disease;Vitamin B6;Work;Yellow Fever;ZIKA;Zika Virus

PROJECT_TITLE: Sex determination and the sex-determining locus in aedine mosquitoes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DCAI-J(02)]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Disability Research;Genetic Testing;Genetics;Human Genome;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE Genetic testing is increasingly used in ill neonates and holds promise to improve care, but the uncertainty of many genetic results complicates their application to clinical practice and poses an important hazard. Uncertainty can lead both clinicians and parents to misunderstand or misapply findings, resulting in biased treatment plans. The proposed research is designed to identify the potential risks that emerge as neonatologists and parents interpret and apply uncertain genetic results, and to mediate these risks by developing a tool to improve the management and communication of results.

PI_NAMEs: CALLAHAN, KATHARINE PRESS (contact)

PROGRAM_OFFICER_NAME: LOCKHART, NICOLE C

PROJECT_TERMS: ableism;Address;Affect;analog;career;career development;Caring;Childhood;Clinical;clinical practice;Collaborations;Communication;Complex;Confusion;Counseling;Critical Illness;Data;Decision Making;design;Development Plans;Diagnostic;disability;Distress;ethical, legal, and social implication;Ethicists;Ethics;exome sequencing;experience;experimental study;feasibility testing;Genetic;genetic association;genetic counselor;Genetic Diseases;genetic disorder diagnosis;genetic information;genetic technology;genetic testing;genome sciences;genome sequencing;Genomic medicine;hazard;High Prevalence;improved;individualized medicine;Infant;Information Management;innovation;Interview;Lead;Measures;Mediating;Medical;Medicine;Mentors;Mentorship;Methodology;National Human Genome Research Institute;Neonatal Intensive Care Units;neonate;Newborn Infant;Parents;Patients;Physicians;Prognosis;prognostic;Qualitative Methods;Research;Research Methodology;Research Personnel;Risk;Science of genetics;Scientist;simulation;social implication;Standardization;Structure;Taxonomy;Testing;tool;Training;treatment planning;Uncertainty;variant of unknown significance;Video Recording;Vision;Visual

PROJECT_TITLE: Managing the Uncertainty of Genetic Information in Neonates


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza;Rare Diseases;Vector-Borne Diseases

ORG_CITY: LOUISVILLE

ORG_NAME: UNIVERSITY OF LOUISVILLE

PHR: PROJECT NARRATIVE Inflammation is controlled by a cascade of signaling events which are initiated by the secretion of lipid mediators by leukocytes to recruit and activate additional immune cells to sites of infection. Our goal is to define how Y. pestis dysregulation of host lipid mediator synthesis contributes to the establishment of plague. Because the inhibition of inflammation is key to Y. pestis virulence, defining the role of host lipid mediators during plague is essential for us to understand the pathogenesis of this bacterium and provide new insights to improve current plague therapy.

PI_NAMEs: LAWRENZ, MATTHEW B (contact)

PROJECT_TERMS: Acute;Animal Model;Bacteria;Bacterial Infections;Biology;Cells;chemokine;Chemotactic Factors;cytokine;Data;defined contribution;Disease;Eicosanoids;Environment;Event;Family;Goals;host colonization;human disease;Immune;Immune Evasion;Immune response;immunoregulation;improved;in vivo evaluation;Infection;Infection Control;Inflammasome;Inflammation;Inflammation Mediators;Inflammatory;Inflammatory Response;Innate Immune System;innovation;insight;Kinetics;leukocyte mediator;Leukocytes;Leukotriene B4;lipid mediator;Lipids;Lipoxygenase;Lung;Macrophage;mast cell;Mediating;member;Molecular;Mus;mutant;neutrophil;Neutrophil Infiltration;novel;pathogen;Pathogenesis;Pathway interactions;Plague;Pneumonic Plague;Predisposition;Production;Proliferating;Prostaglandin-Endoperoxide Synthase;Proteins;recruit;response;Role;Signal Transduction;Site;System;Testing;Therapeutic Intervention;Time;Tissues;tool;Type III Secretion System Pathway;Virulence;Virulence Factors;Yersinia pestis

PROJECT_TITLE: Impact of inflammatory lipids on Yersinia pestis infection

STUDY_SECTION: BHI

STUDY_SECTION_NAME: Bacterial-Host Interactions Study Section [BHI]


NIH_SPENDING_CATS: Neurosciences

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: Mayo Clinic serves 1.3 million patients annually and operates across the Upper Midwest, Southeast, and Southwest United States. Mayo Clinic Neurology cares for >90,000 adult and pediatric patients annually, is known for diagnosing rare disorders, and has a robust clinical research enterprise. Mayo Clinic is ideally positioned to provide NeuroNEXT the diverse patients with unmet needs and the clinical trialists with expertise in these diseases.

PI_NAMEs: STAFF, NATHAN P (contact)

PROGRAM_OFFICER_NAME: OHAYON, JOAN M

PROJECT_TERMS: Acceleration;Adult;Applications Grants;Arizona;Awareness;career development;Caring;Child;Clinic;Clinical;clinical center;clinical infrastructure;Clinical Research;clinical research site;Clinical Sciences;Clinical Trials;Communities;Community Trial;Contracts;Country;Diagnosis;Disease;Education;Eligibility Determination;Enrollment;Ensure;experience;Faculty;Florida;Funding Mechanisms;Geography;Goals;Grant;improved;Infrastructure;innovation;Institution;Institutional Review Boards;Intervention;Leadership;Life Cycle Stages;member;Midwestern United States;Minnesota;Mission;Modernization;National Center for Advancing Translational Sciences;National Institute of Neurological Disorders and Stroke;Nervous System Disorder;Neurologic;Neurologist;Neurology;Neurosciences;next generation;novel therapeutics;Participant;Patients;pediatric patients;Population;Population Heterogeneity;Positioning Attribute;Principal Investigator;Process;programs;Protocols documentation;Publishing;rare condition;Rare Diseases;Recording of previous events;Research;research facility;Research Personnel;rural setting;Science;Site;Structure;synergism;Therapeutic;therapeutic development;Time;Training;Training Programs;Translational Research;Translations;trial design;United States;United States National Institutes of Health;Work

PROJECT_TITLE: The Mayo Clinic NeuroNEXT Clinical Research Site


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Eye Disease and Disorders of Vision;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences

ORG_CITY: SEATTLE

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE This research will test the hypothesis that a change in how attention is allocated forms the basis of sensory and perceptual processing differences in autism spectrum disorder (ASD). Using brain imaging and behavioral measures, the research will advance our basic understanding of the neural basis for sensory and perceptual processing differences that are commonly observed in ASD.

PI_NAMEs: MURRAY, SCOTT O (contact);WEBB, SARA JANE

PROGRAM_OFFICER_NAME: GILOTTY, LISA

PROJECT_TERMS: adult with autism spectrum disorder;Affect;Attention;Attentional deficit;autism spectrum disorder;autistic;Behavior;behavior measurement;Behavioral;Binding;Brain Diseases;Brain imaging;Cognitive;cognitive process;Color;Communication;Complex;computational basis;Computer Models;Development;Dimensions;Equilibrium;Etiology;experience;experimental study;Eye Movements;Face Processing;flexibility;Frequencies;Functional disorder;Functional Magnetic Resonance Imaging;Goals;Imaging Techniques;Individual;individuals with autism spectrum disorder;information processing;Measures;model of autism spectrum disorder;Modeling;Motion;Motion Perception;neural;Neurophysiology - biologic function;predictive modeling;Process;Property;Psychophysics;Quality of life;Reaction;repetitive behavior;Research;Resources;response;Sensory;sensory input;social communication;Social Interaction;Stimulus;Symptoms;Testing;Time;Visual;Visual Cortex;Visual Motion;Visual Perception;Width;Work

PROJECT_TITLE: Attention allocation as a computational mechanism for altered sensory processing in autism

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Immunotherapy;Neurosciences;Orphan Drug;Pancreatic Cancer;Rare Diseases

ORG_CITY: La Jolla

ORG_NAME: SALK INSTITUTE FOR BIOLOGICAL STUDIES

PHR: PROJECT NARRATIVE Interactions between pancreatic cancer cells and non-transformed cells in a tumor are essential for cancer growth and progression. Reprogramming these metabolic networks is a promising strategy for enhancing therapeutic efficacy in pancreatic cancer. I will use new mouse models and cutting-edge metabolomic techniques to determine how immune and nerve cells support pancreatic cancer growth through metabolic interactions.

PI_NAMEs: KERK, SAMUEL ANDREW (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: Ablation;Affect;amino acid metabolism;Amino Acids;Animals;anti-tumor immune response;Architecture;Aspartate;Biochemical Pathway;Bioenergetics;blood vessel development;Cancer Biology;cancer cell;cancer infiltrating T cells;career;career development;Cell Physiology;Cells;Chemicals;chemotherapy;Clinical Trials;Coculture Techniques;Communication;Complex;conditional knockout;Coupled;CRISPR library;cytotoxic;cytotoxicity;Data;Deoxycytidine;Desmoplastic;Disease;Doctor of Philosophy;Effector Cell;Equilibrium;Fellowship;Fibroblasts;gemcitabine;Genes;Genetic;Genetic Screening;Genome;Glutamates;Goals;GOT2 gene;graduate school;Growth;Immune;Immune system;Immunocompetent;Immunotherapy;Impairment;in vivo;in vivo Model;Infiltration;inhibitor;Investigation;Isotopes;Knock-out;Knowledge;Libraries;Macrophage;Malignant - descriptor;Malignant neoplasm of pancreas;Malignant Neoplasms;Mediating;Mentorship;Metabolic;metabolic abnormality assessment;Metabolic Pathway;Metabolism;metabolomics;Mitochondria;mitochondrial metabolism;Modeling;Molecular;mouse model;Mus;Myelogenous;Nature;Nerve;Nervous System;neural;neural network;Neurons;neurotransmission;Neurotransmitters;novel therapeutics;nucleobase;Nutrient;Oxaloacetates;Oxidation-Reduction;Oxygen;pancreatic cancer cells;pancreatic cancer model;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;pancreatic ductal adenocarcinoma model;pancreatic neoplasm;Peripheral Nerves;Phase;Physiological;Population;Postdoctoral Fellow;Production;Proliferating;Pyrimidine;Pyrimidines;Pyruvate;recruit;Regulatory T-Lymphocyte;Repression;Research Personnel;Resistance;response;Role;Signal Transduction;Support System;Supporting Cell;T-Lymphocyte;targeted treatment;Technical Expertise;Techniques;Testing;Therapeutic;therapy resistant;Tissues;Training;Transaminases;Treatment Efficacy;tumor;tumor ablation;tumor growth;tumor metabolism;tumor microenvironment;Tumor-associated macrophages;Tumor-Infiltrating Lymphocytes;tumorigenesis;tumorigenic;Vertebral column;Work

PROJECT_TITLE: Reprogramming Metabolic Networks in the Tumor Microenvironment


ORG_CITY: BOSTON

ORG_STATE: MA

PHR: NARRATIVE STATEMENT Cancer is a significant cause of morbidity and mortality worldwide. The immune system has the capacity to fight cancer, but it becomes disabled as cancer progresses. The proposed studies will advance our knowledge of how tumor cells and immune cells influence each other’s metabolism over the course of tumor progression with the goal of devising new anti-cancer therapies.

PI_NAMEs: ANDERSON, ANA C (contact);KUCHROO, VIJAY K.

PROGRAM_OFFICER_NAME: LIU, YIN

PROJECT_TERMS: Acetylation;Acetyltransferase;Affect;Algorithmic Analysis;Autoimmunity;Biochemical Pathway;cancer cell;cancer therapy;CD8-Positive T-Lymphocytes;Cell Physiology;cell type;Cells;Cellular Metabolic Process;Computing Methodologies;conditional mutant;Data;Data Set;design;disabled;Ecosystem;effector T cell;Enzymes;Equilibrium;exhaust;fighting;Genes;Goals;Immune;immune cell infiltrate;Immune system;Immune Targeting;Immune Tolerance;Immunity;in silico;In Situ;in vivo;Individual;Knowledge;longitudinal analysis;Malignant Neoplasms;Maps;Mediating;Melanoma;Melanoma Cell;Melanoma Tumor;Metabolic;metabolic profile;Metabolism;metabolomics;Methods;Modeling;Morbidity - disease rate;mortality;mouse model;Mus;Mutant Strains Mice;Myelogenous;Myeloid Cells;Myeloid-derived suppressor cells;neoplastic cell;Network-based;novel;nutrient deprivation;Outcome;Oxidative Phosphorylation;Pathway interactions;Phenotype;Polyamines;Population;pre-clinical;Production;Productivity;Proliferating;Recycling;Regulatory T-Lymphocyte;Resolution;response;Role;S100A9 gene;Shapes;single-cell RNA sequencing;Spermidine;Spermine;stemness;Symbiosis;System;targeted treatment;Therapeutic Intervention;Time;Tissue Harvesting;Tissues;tool;transcriptomics;tumor;Tumor Immunity;tumor microenvironment;tumor progression;wasting

PROJECT_TITLE: Role of metabolic crosstalk in determining immunity during tumor progression

STUDY_SECTION: CCB

STUDY_SECTION_NAME: Cancer Cell Biology Study Section[CCB]


NIH_SPENDING_CATS: Aging;Biotechnology;Brain Cancer;Brain Disorders;Cancer;Immunotherapy;Neurosciences;Radiation Oncology;Rare Diseases

ORG_CITY: MAYWOOD

ORG_DEPT: BIOLOGY

ORG_NAME: LOYOLA UNIVERSITY CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Advanced aging is the most common factor associated with a diagnosis of adult glioblastoma (GBM) with wild- type isocitrate dehydrogenase; constituting 90% of all GBM diagnoses and made famous for its association with taking the lives of notable individuals including the late U.S. Senators Ted Kennedy and John McCain. Advanced aging is also associated with increased brain-resident dendritic cells (DCs), sentinel cells of the immune system, as well as a potently immunosuppressive factor, indoleamine 2,3 dioxygenase 1 (IDO1). Here, I will investigate the novel hypothesis that, advanced aging increases brain DCs expressing immunosuppressive IDO1, which enhances the incidence and decreases the responsiveness to immunotherapy of subjects with GBM.

PI_NAMEs: WAINWRIGHT, DEREK ALAN (contact)

PROGRAM_OFFICER_NAME: HAAKENSON, CHELSEA MARIE

PROJECT_TERMS: Address;Adult;Adult Glioblastoma;Affect;Aftercare;Age;age group;age related;Aging;Animals;anti-CTLA4;anti-PD-1;anti-PD1 therapy;Bone Marrow;Brain;Cell Lineage;Cell Physiology;Cells;Central Nervous System;Central Nervous System Neoplasms;chemotherapy;Clinical Treatment;Clinical Trials;Combined Modality Therapy;Data;Death Rate;Dendritic Cells;Diagnosis;Disease;Effectiveness;Elderly;Engraftment;Enrollment;enzyme activity;Enzyme Inhibition;Enzyme Inhibitor Drugs;Enzymes;Excision;experience;Future;Gene Expression;Glial Fibrillary Acidic Protein;Glioblastoma;Goals;Human;human old age (65+);Immune response;Immune system;Immunocompetent;Immunologic Surveillance;immunosenescence;Immunosuppression;Immunotherapeutic agent;Immunotherapy;improved;Incidence;Individual;Injections;Isocitrate Dehydrogenase;juvenile animal;Malignant Neoplasms;Mediating;Metabolic;Metabolism;Modality;Modeling;Monoclonal Antibodies;Mus;neoplastic cell;Neuroimmune;Nivolumab;novel;old mice;Operative Surgical Procedures;Patients;peripheral blood;Phase III Clinical Trials;Phenotype;prevent;Prevention strategy;Primary Brain Neoplasms;Prognosis;programmed cell death protein 1;programs;Radiation therapy;Reporter;Research;response;Scientist;Sentinel;Signal Transduction;Source;standard of care;Study models;success;T-Lymphocyte;Tamoxifen;temozolomide;Therapeutic Effect;Time;Training;transcriptome sequencing;Transgenic Mice;Tryptophan 2,3 Dioxygenase;tumor;tumor growth;Tumor Tissue;Wild Type Mouse;Work

PROJECT_TITLE: Aging, immunosenescence and glioblastoma

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Biological Aging Study Section[NIA-B]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Genetics;Women's Health Research

ORG_CITY: SAN DIEGO

ORG_NAME: SAN DIEGO STATE UNIVERSITY

ORG_STATE: CA

PHR: PROJECT NARRATIVE The results of this project will generate new insight into the role of mismatch repair proteins in regulating tumor behavior beyond their impact on maintaining genome stability. It will also provide first understanding of the functional impact of heterogeneous loss of mismatch repair proteins on tumor growth and treatment response.

PI_NAMEs: HARICHARAN, SVASTI  (contact)

PROGRAM_OFFICER_NAME: BERA, TAPAN K

PROJECT_TERMS: Affect;Antibodies;behavior influence;betacellulin;Breast Cancer Cell;cancer cell;cancer diagnosis;carcinogenesis;Cell Communication;Cell Culture Techniques;Cells;Clinical;cytokine;Cytosol;Data;Dependence;Diagnosis;digital;Dimerization;DNA;DNA Repair;DNA Sequence Alteration;ERBB2 gene;ErbB4 gene;Estrogen receptor positive;Experimental Models;Family member;FDA approved;Genome Stability;Goals;Growth;heparin-binding EGF-like growth factor;Heterodimerization;hormone therapy;Impairment;In Situ;In Vitro;in vivo;Inflammatory;inhibitor;insight;interest;Ligand Binding;Ligand Binding Domain;Ligands;Link;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Neoplasms;Mediating;Metastatic breast cancer;Mismatch Repair;MLH1 gene;Mutagenesis;Mutate;Mutation;neoplastic cell;Neuregulin 1;novel;novel therapeutic intervention;overexpression;Pathway interactions;Patients;Pattern;Phenotype;predicting response;Predictive Value;Predisposition;prognostic value;Proteins;Publishing;Receptor Protein-Tyrosine Kinases;Regulation;Research;Resistance;resistance mechanism;RNA Interference;Role;Seminal;Signal Transduction;Stimulator of Interferon Genes;Testing;Therapeutic;therapy resistant;treatment response;tumor;tumor behavior;tumor growth;tumor microenvironment;Tumor Suppressor Proteins;Woman;women's diagnosis;Work

PROJECT_TITLE: Regulation of the tumor microenvironment by DNA damage repair proteins