ADMINISTERING_IC: OH

IC_NAME: NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH

ORG_CITY: WEST LAFAYETTE

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: Project Narrative Despite advances in automation, manual material handling (MMH) tasks continue to be commonplace in the workplace. Poorly designed and controlled MMH tasks present a substantial health and safety burden in the United States (US) and worldwide. The proposed research will develop novel materially engineered triboelectric wearable and real-time based system that can be widely implemented for 1) accurately identifying both hand activity level and hand force exertions during MMH task performance and 2) predicting the worker threshold limit values (TLV) for upper extremity injury risk during repetitive MMH tasks.

PI_NAMEs: YU, DENNY  (contact)

PROGRAM_OFFICER_NAME: CHIOU, SHARON

PROJECT_TITLE: Skin-interfaced triboelectric sensors continuously monitor worker forceexertions to prevent workplace injuries

STUDY_SECTION: SOH

STUDY_SECTION_NAME: Safety and Occupational Health Study Section[SOH]


ADMINISTERING_IC: EB

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_CITY: LA JOLLA

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: Project Narrative The microbes in our guts, our microbiome, intimately affect our health, wellness, disease states, and even response to medicines. Unfortunately, microbiomes are difficult to measure; the easily obtained samples that emerge from the ends of our guts do not accurately represent what's inside, nor do they tell us anything about the microbiome's spatial structure across the intestinal tract. This work will develop biosensors that continuously sample free DNA, thus preserving a record of what they see on their way through the gut.

PI_NAMEs: COOPER, ROBERT M (contact)

PROGRAM_OFFICER_NAME: CHEN, JERMONT

PROJECT_TERMS: Affect;Antibiotics;Bacteria;Benign;Biosensor;Cells;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;colon microbiota;Colorectal Neoplasms;Competence;Confounding Factors (Epidemiology);CRISPR interference;Detection;Diagnostic;Diagnostic Procedure;Disease;DNA;DNA Integration;DNA Sequence;drug development;Drug usage;ds-DNA;dysbiosis;Electroporation;Elements;Enzymes;Escherichia coli;experimental study;extracellular;Feces;Frequencies;Future;Gastrointestinal tract structure;Genes;Genetic Transcription;Genome;Genomics;Goals;gut microbes;gut microbiome;gut microbiota;Health;Health Promotion;homologous recombination;Human;In Vitro;in vivo;Individual;innovation;Integrase;Intestinal Cancer;Intestines;Malignant Neoplasms;Measurement;Measures;Medicine;Mental Health;Metabolic;Metabolic Diseases;Metabolism;metagenomic sequencing;Methods;Microbe;microbial;microbial composition;microbiome;microbiome alteration;microbiota;Mobile Genetic Elements;mouse model;Mus;novel diagnostics;Oral;overexpression;Pathogenicity;personalized medicine;Pharmaceutical Preparations;Plasmids;preference;preservation;Records;response;Risk;Sampling;Single-Stranded DNA;Site;Source;Stimulus;stool sample;Structure;System;Techniques;Testing;treatment planning;Work

PROJECT_TITLE: DNA Recorder: Living biosensor for arbitrary DNA

STUDY_SECTION: EBIT

STUDY_SECTION_NAME: Enabling Bioanalytical and Imaging Technologies Study Section[EBIT]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Lung;Networking and Information Technology R&D (NITRD);Pediatric;Physical Activity;Physical Rehabilitation;Prevention;Pulmonary Hypertension;Rare Diseases;Rehabilitation;Telehealth

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Narrative Pulmonary arterial hypertension patients have reduced exercise capacity and quality of life, both of which improve with physical activity. We recently demonstrated that smartphone-based mobile health interventions lead to increased activity, capacity, and quality of life in adults with this condition. Given the unique needs of adolescents and their caregivers, we propose a clinical trial to test the feasibility of a mobile health intervention to increase step counts, quality of life, and other metrics in adolescents with pulmonary arterial hypertension.

PI_NAMEs: AUSTIN, ERIC DOUGLAS (contact);BRITTAIN, EVAN L;JASER, SARAH SANDERS

PROGRAM_OFFICER_NAME: LACHOWICZ-SCROGGINS, MARRAH ELIZABETH

PROJECT_TERMS: Activities of Daily Living;Adipose tissue;Adolescent;Adult;Adverse event;Affect;Age;arm;Award;Behavior Therapy;Behavioral;Brain natriuretic peptide;Cardiopulmonary rehabilitation;caregiver stress;Caregivers;Cellular Phone;Child;Childhood;Clinical;Clinical Trials;Communication;Communities;Coping Skills;cost effective intervention;Data;data exchange;design;Development;Devices;diabetes management;Diabetes Mellitus;Dropout;Effectiveness;Effectiveness of Interventions;Enrollment;Environment;Equipment and supply inventories;Exercise;exercise capacity;experience;feasibility testing;Feedback;Feeling;fitbit;Focus Groups;Functional impairment;Funding;Goals;gratitude;Habits;Happiness;Health Technology;Impairment;improved;Inpatients;interest;Intervention;Lead;Link;Measures;Medical;mHealth;mhealth interventions;Monitor;Morbidity - disease rate;mortality;muscle strength;off-label use;parental influence;Participant;Patient Self-Report;Patients;pediatric patients;Persons;Pharmaceutical Preparations;phase II trial;Physical activity;pilot trial;Population;primary endpoint;Protocols documentation;Psychology;Publishing;pulmonary arterial hypertension;Qualifying;Quality of life;Randomized;Rehabilitation therapy;Resources;Right Ventricular Function;secondary analysis;secondary endpoint;sex;SF-36;Skeletal Muscle;Stress;Stress and Coping;stress management;tailored text messaging;Text;Text Messaging;text messaging intervention;Theory of Change;therapy adherence;Time;tool;treatment arm;treatment as usual;United States;United States National Institutes of Health;Visceral;Visit;Walking;Work;Youth

PROJECT_TITLE: MhOVE-PPH Study: Mobile health interventiOn to improVe Exercise in Pediatric PH

STUDY_SECTION: SSPT

STUDY_SECTION_NAME: NHLBI Single-Site and Pilot Clinical Trials Study Section[SSPT (JA)]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Chronic Liver Disease and Cirrhosis;Coronaviruses;Digestive Diseases;Emerging Infectious Diseases;Genetics;Hepatitis;Infectious Diseases;Liver Disease;Lung;Nutrition;Obesity

ORG_CITY: PHILADELPHIA

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: NARRATIVE Preexisting cirrhotic liver disease is strongly associated with severe COVID-19 outcome, including long COVID and death. Recently strong evidence has emerged that senescence, a physiological state of cells that is characterized by cell cycle arrest and pro inflammatory responses, is a functional feature of both cirrhotic liver disease and also is directly induced by SARS-CoV-2 in infected cells. We aim at testing if specific removal of senescent cells will alleviate severe COVID-19 symptoms in SARS-CoV-2 infected mice with preexisting NASH, or in SARS-CoV-2 infected NASH patient liver- derived organoids.

PI_NAMEs: RAABE, TOBIAS D. (contact)

PROGRAM_OFFICER_NAME: PLIMACK, MARY KATHERINE BRADFORD

PROJECT_TERMS: 2019-nCoV;Adipocytes;Adipose tissue;Aftercare;Air;airway epithelium;Alveolar;Animals;CCL4 gene;Cell Cycle Arrest;Cell Survival;cell type;Cells;Cessation of life;Chemicals;chemokine;Cirrhosis;Clinic;Clinical;Collaborations;COVID-19;COVID-19 cytokine storm;COVID-19 patient;COVID-19 treatment;CXCL10 gene;cytokine;Dasatinib;Diet;diet-induced obesity;Dose;Enzyme-Linked Immunosorbent Assay;Epithelial Cells;Excision;Exhibits;experience;Fibrosis;Ganciclovir;Genetic;Hamsters;Hepatocyte;Hepatology;High Fat Diet;Human;human model;Infection;Inflammation;Inflammatory;Inflammatory Response;Insulin Resistance;Interferons;knock-down;Liquid substance;Liver;Liver diseases;Liver Fibrosis;Long COVID;Lung;Macrophage;Measures;Metabolic Diseases;Modeling;Morbid Obesity;mouse model;Mus;nonalcoholic steatohepatitis;novel;obese person;Obesity;Organoids;Outcome;Pathology;Patients;Pennsylvania;phenotypic biomarker;Physiological;Play;Quercetin;response;Role;SARS-CoV-2 infection;senescence;senescence associated secretory phenotype;senescent cell;senolytics;senomorphic;severe COVID-19;small hairpin RNA;Symptoms;synergism;Testing;Time;Tissues;transcriptome sequencing;Transgenes;Transgenic Mice;Translating;Universities;Virion;Virus;Virus Inactivation

PROJECT_TITLE: The role of senescence in severe COVID-19

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


ORG_CITY: WORCESTER

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

ORG_STATE: MA

PHR: PROJECT NARRATIVE Cell death pathways are essential to several aspects of biological pathways—from development to disease to immune responses to pathogens. The final step in the cell death pathway is plasma membrane rupture, a process which involves a protein known as Ninjurin 1 (Ninj1), which forms large pores on the membrane surface. This proposal will elucidate the mechanisms of Ninj1-mediated membrane rupture and assess its role in the immune response to pathogens using a Yersinia infection model.

PI_NAMEs: LIEN, EGIL  (contact)

PROGRAM_OFFICER_NAME: SINGLETON, KENTNER L

PROJECT_TERMS: Address;alpha helix;Anti-Bacterial Agents;Apoptotic;Automobile Driving;Bacteria;Bacterial Infections;Biological;Biological Process;Bone Marrow;CASP1 gene;CASP8 gene;Cell Death;Cell membrane;Cell Physiology;Critical Pathways;cytokine;Data;Development;Disease;Event;experimental study;Family;Family member;Host Defense;Hybrids;Immune response;Immune signaling;Immunity;In Vitro;in vivo;Infection;Inflammation;Inflammatory;inhibitor;Innate Immune Response;Knowledge;Macrophage;Mediating;Membrane;Modeling;mouse model;Mus;Mutation;Myeloid Cells;N-terminal;novel;pathogen;Pathway interactions;Perforation;Process;Proteins;Regulation;response;RIPK1 gene;Role;Rupture;Signal Pathway;Signal Transduction;Surface;System;TNF gene;Toll-like receptors;tool;VDAC1 gene;Yersinia;Yersinia infections

PROJECT_TITLE: Regulation of Ninj1 oligomerization and cell membrane ruptures during cell death

STUDY_SECTION: BHI

STUDY_SECTION_NAME: Bacterial-Host Interactions Study Section [BHI]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Mental Health;Neurodegenerative;Neurosciences;Patient Safety;Prevention

ORG_CITY: SAINT LOUIS

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Postoperative delirium is a debilitating and potentially preventable neurological complication in aged adults at risk for Alzheimer's disease and related dementias. While there is currently no pharmacologic agent to prevent delirium, fluvoxamine is an antidepressant that may reduce systemic and neuroinflammation involved in the pathogenesis of this costly disorder. The proposed investigation will establish biological plausibility and infrastructure required for a multisite clinical trial evaluating the repurposing of fluvoxamine to mitigate delirium risk and potential progression of long-term cognitive decline towards Alzheimer's disease.

PI_NAMEs: PALANCA, BEN JULIAN (contact);SANDERS, ROBERT D

PROGRAM_OFFICER_NAME: ROBERTS, LUCI

PROJECT_TERMS: Accounting;Adult;Adverse event;Age;aged;aging population;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Animal Model;Animals;anti-depressive agents;Antiinflammatory Effect;arm;axon injury;Biological;Biological Markers;Blinded;Blood;Brain;Case Series;Case Study;Clinical;Complication;Confidence Intervals;confusion assessment method;cost;COVID-19;Critical Illness;cytokine;Data;Delirium;density;Deterioration;Diarrhea;Disease;Dose;Drops;Drug Interactions;efficacy trial;Electroencephalography;Eligibility Determination;Enrollment;Evaluation;Exclusion Criteria;Failure;feasibility trial;Fluvoxamine;follow-up;Future;General Anesthesia;Goals;Half-Life;Headache;Healthcare Systems;Hospitalization;Hospitals;Human;Impaired cognition;improved;improved outcome;Incidence;Inflammation;Infrastructure;insight;Intensive Care Units;Interleukin-6;Intervention;Investigation;Investments;Learning;Light;Lipopolysaccharides;Measures;Mediating;Multi-Institutional Clinical Trial;Multicenter Trials;Mus;Nausea;neurofilament;neuroinflammation;Neurologic;Neuronal Dysfunction;neuroprotection;older adult;Operative Surgical Procedures;Oral;Outcome;Outcome Measure;Participant;participant enrollment;Pathogenesis;Pathway interactions;Patient Recruitments;Patients;Performance;Perioperative;Pharmaceutical Preparations;pharmacologic;Phase;phase III trial;Physiological;pilot trial;placebo controlled trial;Placebos;Plasma;Populations at Risk;postoperative delirium;Postoperative Period;precision medicine;prevent;primary outcome;Prostaglandins;Protocols documentation;Public Health;Quality of life;Randomized;Randomized, Controlled Trials;Regression Analysis;Risk;risk mitigation;safety and feasibility;safety outcomes;Sample Size;Sampling;Schedule;secondary outcome;Sepsis;septic;Severities;side effect;sigma-1 receptor;Site;Sleeplessness;social stigma;Synaptic plasticity;systemic inflammatory response;Testing;treatment arm;trial enrollment;Width;Work

PROJECT_TITLE: Mitigating Delirium with Fluvoxamine Treatment for Non-Cardiac Surgery (MD FluNCS): Feasibility Trials & Mechanistic Insights

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Social Determinants of Health

ORG_CITY: Los Angeles

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Project Narrative Parenting interventions that promote responsive caregiving can help remediate early disadvantages for the 43% of children under five in low- and middle-income countries (LMICs) who experience compromised early childhood development (ECD), but very few programs examine their sustained effects, and the only LMIC evidence of long-term impacts stems from two very tiny and intensive pilot ECD studies in Jamaica. Our study will conduct a five-year follow-up survey of a longitudinal sample of households across 60 villages in rural Kenya that demonstrated positive impacts from a scalable and cost-effective ECD program up to two years later. Our proposed survey extension can help fill a gap regarding long-term evidence on the effectiveness of ECD programs, as well as shed light on any mechanisms explaining how such impacts were sustained or dissipated to inform the design of future ECD programs.

PI_NAMEs: LOPEZ GARCIA, ITALO  (contact)

PROGRAM_OFFICER_NAME: MILLER, BRETT

PROJECT_TERMS: 8 year old;Adult;African;Age;Automobile Driving;Behavior;Behavioral;Belief;caregiving;Child;Child Development;Child Rearing;Cognitive;Cohort Studies;Communities;cost effective;cost effectiveness;Cost-Benefit Analysis;COVID-19 pandemic;Data;Data Set;design;Development;Disadvantaged;early childhood;Effectiveness;Emotional;Enrollment;executive function;experience;Exposure to;Family;follow up assessment;follow-up;Future;Goals;Group Meetings;Home visitation;Household;human capital;improved;Individual;Intervention;Investments;Jamaica;Kenya;Knowledge;Language;Life Cycle Stages;low and middle-income countries;Low Birth Weight Infant;Measures;Mediating;Mediation;Mediator;middle childhood;Modeling;National Institute of Child Health and Human Development;Neuronal Plasticity;novel;Outcome;parenting intervention;Parents;Pathway interactions;peer learning;Performance;Pilot Projects;Play;Policies;Poverty;Primary Schools;Production;Program Development;programs;psychosocial;Publishing;Records;remediation;Research Personnel;Resources;Role;Rural;Sampling;School-Age Population;Schools;Siblings;skills;Social Network;social norm;Social support;stem;Surveys;Testing;therapy development;Time;Update;urban children;Work

PROJECT_TITLE: Can Successful Early Childhood Interventions Sustain Impacts into Middle Childhood? A test from Kenya

STUDY_SECTION: SSPA

STUDY_SECTION_NAME: Social Sciences and Population Studies A Study Section[SSPA]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Lung;Lung Cancer;Prevention;Racial and Ethnic Minority Health Research;Tobacco;Tobacco Smoke and Health

ORG_DEPT: SURGERY

PHR: Black/African American men have the highest rate of lung cancer morbidity and mortality among all groups, with a 12% higher lung cancer incidence rate and a 15% higher lung cancer death rate than White/European men. We have identified a small genetic difference (called a single nucleotide polymorphism or “SNP”), that is rare in White/European individuals but is present in one third of Black/African American individuals. The SNP might affect the function of a protein involved in detoxification responses to tobacco smoke, and may thereby affect the lung cancer risk of smokers carrying this SNP. If true, this will be important information supporting lung cancer screening and tobacco cessation efforts in the Black/African American community.

PI_NAMEs: OFFRINGA, ITE A (contact)

PROGRAM_OFFICER_NAME: WALLACE, TIFFANY A

PROJECT_TERMS: Affect;African American;African American population;Alleles;alveolar epithelium;Amino Acids;ARNT gene;Aromatic Polycyclic Hydrocarbons;Aryl Hydrocarbon Receptor;ATAC-seq;Binding;Biochemical;Biosensor;Black American;Black race;Cancer Death Rates;cancer risk;Carcinogens;Cell Line;Cell Nucleus;Cells;Cessation of life;chromatin immunoprecipitation;cigarette smoke;Cleavage Under Targets and Release Using Nuclease;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;Communities;Complex;Data;dimer;Dimerization;Dissociation;Drug Metabolic Detoxication;Engineering;European;European ancestry;Exons;experience;Gene Frequency;Genes;Genetic;genetic association;Genetic Transcription;Genetic Variation;Genome;genome editing;genome wide association study;Genotype;Heterodimerization;Heterozygote;Human;improved;In Vitro;Incidence;Individual;insight;instrument;Kinetics;Leucine;lung cancer screening;male;Malignant neoplasm of lung;Measures;men;Metabolism;Minor;Modeling;Molecular Conformation;Morbidity - disease rate;mortality;Outcome;Pilot Projects;Population;Positioning Attribute;Proline;Protein Dynamics;protein function;Proteins;receptor binding;Recombinant Proteins;response;Response Elements;Role;Single Nucleotide Polymorphism;Site;Smoker;Smoking;smoking-related cancer;Structure;Techniques;Testing;Tobacco smoke;tobacco smoke exposure;Tobacco Use Cessation;transcriptome sequencing;Variant;Xenobiotics

PROJECT_TITLE: Analysis of a missense SNP in the aryl hydrocarbon receptor repressor gene that may disproportionately increase lung cancer risk in Black Americans

STUDY_SECTION: BMCD

STUDY_SECTION_NAME: Basic Mechanisms of Cancer Health Disparities Study Section[BMCD]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Physical Activity;Physical Injury - Accidents and Adverse Effects;Physical Rehabilitation;Rehabilitation;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_CITY: CHICAGO

ORG_NAME: REHABILITATION INSTITUTE OF CHICAGO D/B/A SHIRLEY RYAN ABILITYLAB

ORG_STATE: IL

PHR: Project Narrative: Current locomotor training programs result in limited improvements in walking ability in individuals with chronic incomplete spinal cord injury (SCI). Here, we propose to assess the contribution of the reticulospinal tract (RST), a major but largely under investigated descending motor tract in humans, to the control of lower limb muscles during locomotion and to apply a novel paradigm aiming to engage RST projections to lower limb muscles in combination with locomotor training to improve walking ability in individuals with chronic SCI. The results of this work will contribute to understand RST contributions to lower limb muscles and might contribute to developing new non-invasive techniques to improve locomotor function in individuals living with SCI.

PI_NAMEs: DE SANTIS, DALIA  (contact)

PROGRAM_OFFICER_NAME: NITKIN, RALPH M

PROJECT_TERMS: Acceleration;Acoustic Stimulation;Acoustics;auditory stimulus;Bilateral;Body Weight;Chronic;Clinical Trials;Communities;Compensation;daily functioning;Electric Stimulation;Electromyography;equilibration disorder;Fiber;Future;Goals;hamstring;Human;Impairment;improved;Individual;Intervention;Investigation;Leg;Life Expectancy;Locomotion;Locomotor Recovery;Locomotor training;Loudness;Lower Extremity;Measures;Motor;Motor output;Motor Pathways;Muscle;muscle strength;Muscle Weakness;Musculoskeletal Equilibrium;Neurologic;neuroregulation;novel;Outcome;Output;Paralysed;Pathway interactions;Persons;Pilot Projects;Play;post stroke;Predisposition;Protocols documentation;quadriceps muscle;Quality of life;Randomized;Recovery;response;reticulospinal tract;Role;Running;Sensory;Skeletal Muscle;Soleus Muscle;Spinal cord injury;Stimulus;Techniques;Testing;tibialis anterior muscle;Toes;Training;Training Programs;treadmill;treadmill training;Upper Extremity;walker;Walking;walking speed;Work

PROJECT_TITLE: Engaging reticulospinal inputs to improve walking

STUDY_SECTION_NAME: Special Emphasis Panel[ZHD1 DSR-G (02)]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Coronaviruses;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: Aurora

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative/Public Health Relevance COVID-19 has affected all aspects of life resulting in significant loss of life, productivity, and economic growth. The world does not want to face another COVID pandemic. This proposal aims to understand the evolution of SARS-CoV-2 mutations and potential future coronaviruses that can infect humans.

PI_NAMEs: MALLELA, KRISHNA M.G. (contact)

PROJECT_TERMS: 2019-nCoV;ACE2;Affect;Affinity;Affinity Chromatography;Antibodies;Binding;Binding Proteins;Bioinformatics;Biological Assay;Cataloging;Cell Culture Techniques;Cell Surface Receptors;Cells;Cessation of life;Chimeric Proteins;Chiroptera;Communication;Computer Models;computer studies;Coronavirus;coronavirus receptor;Coronavirus spike protein;COVID-19;COVID-19 outbreak;COVID-19 pandemic;Cryoelectron Microscopy;Data;Death Rate;Diagnosis;Disease;Disease Outbreaks;Distant;Economics;effective therapy;Embryo;Evolution;Experimental Designs;Face;Flow Cytometry;Fluorescence;Fluorescence Resonance Energy Transfer;Fluorescence-Activated Cell Sorting;Future;Grant;Growth;Human;human coronavirus;Immune;Immune system;Individual;infection rate;Kidney;kidney cell;Knowledge;Lead;Length;Life;Lung;Mammalian Cell;Mass Spectrum Analysis;Measures;Methods;Molecular;Molecular Conformation;monomer;mortality;mutant;Mutation;N-terminal;Natural Selections;neutralizing antibody;novel coronavirus;pandemic disease;Pathway interactions;Patients;Persons;Population;Productivity;Proteins;public health relevance;Publishing;Readiness;receptor;receptor binding;Recombinants;respiratory;Respiratory System;Role;SARS coronavirus;SARS-CoV-2 spike protein;Sequence Analysis;Sequence Homology;Structure;Surface;Surface Plasmon Resonance;Techniques;Testing;therapeutically effective;trend;Variant;Virus;Yeasts

PROJECT_TITLE: Structure-Function Analysis of Human and Bat Coronavirus Spike Proteins

STUDY_SECTION: MSFC

STUDY_SECTION_NAME: Macromolecular Structure and Function C Study Section[MSFC]


NIH_SPENDING_CATS: Biotechnology;Duchenne/ Becker Muscular Dystrophy;Gene Therapy;Genetics;Muscular Dystrophy;Orphan Drug;Pediatric;Rare Diseases

ORG_CITY: LOS ANGELES

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative Duchenne muscular dystrophy (DMD) is a lethal pediatric neuromuscular disorder resulting from loss of dystrophin protein. To restore dystrophin production, we will develop a new type of antisense oligonucleotide drugs that recognizes not only the sequence but also the structure of dystrophin's precursor messenger RNA. We expect these “3D” drugs to be more potent, more efficacious, and of fewer side effects than the existing drugs.

PI_NAMEs: GUO, FENG  (contact);MICELI, M CARRIE

PROGRAM_OFFICER_NAME: SURPRIS, MARIPIERRE PAYEN

PROJECT_TERMS: 3-Dimensional;Address;Affect;Affinity;Animal Model;Antisense Oligonucleotide Therapy;Antisense Oligonucleotides;Automobile Driving;base;Base Pairing;Binding;Binding Sites;Biochemical;Biological Assay;boys;Calorimetry;Cardiac;Cell Culture Techniques;Cell Line;Cell Membrane Permeability;Cells;Cellular Assay;Chemicals;Chemistry;Childhood;clinical efficacy;Clinical Trials;Competitive Binding;Complex;Crystallization;Data;design;Development;Disease;Disease Progression;Duchenne muscular dystrophy;Dystrophin;Effectiveness;Endosomes;Engineering;exon skipping;Exons;Extracellular Matrix;FDA approved;Future;Genes;Glycoproteins;Heart failure;improved;in vitro testing;innovation;Life;Link;Major Groove;Measurement;Measures;Messenger RNA;Modality;Molecular;Molecular Conformation;mRNA Precursor;Muscle Cells;Muscle Fibers;muscle progenitor cell;Muscular Atrophy;Mutation;Myoblasts;Natural regeneration;Neuromuscular Diseases;novel;Oligonucleotides;Patients;Penetrance;Penetration;Peptide Library;Peptides;Pharmaceutical Preparations;Precision therapeutics;Production;protein aminoacid sequence;Proteins;Rare Diseases;rational design;Reading Frames;Resolution;Respiratory Failure;Reverse Transcriptase Polymerase Chain Reaction;RNA;RNA Splicing;side effect;Site;Specificity;Structure;Structure-Activity Relationship;Surveys;Testing;therapeutic target;Tissues;Titrations;Transfection;United States Food and Drug Administration;Vertebral column;virtual

PROJECT_TITLE: Structure-based antisense therapeutics targeting dystrophin exons 44 and 45 for Duchenne Muscular Dystrophy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-M (81)]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric

ORG_DEPT: NEUROSCIENCES

PHR: PUBLIC HEALTH RELEVANCE Published estimates indicate that 1 in 44 children are diagnosed with Autism Spectrum Disorder (ASD) (https://www.cdc.gov/), and while many genetic causes of ASD and related neurodevelopmental disorders have now been discovered, these discoveries have not yet been translated into gene-based treatments for these disorders. This project will use a newly developed mouse strain to test the feasibility of reinstating the function of the DNMT3A gene in order to treat neurodevelopmental disorders caused by mutation of this gene. This work will establish new tools to study therapeutics for DNMT3A-associated disorders and provide fundamental insights into the feasibility of treating an entire class of neurodevelopmental disorders caused by disruption of “epigenetic writer” genes that are related to DNMT3A.

PI_NAMEs: GABEL, HARRISON W (contact)

PROGRAM_OFFICER_NAME: RIDDLE, ROBERT D

PROJECT_TERMS: Address;Adult;Alleles;Anatomy;Angelman Syndrome;Anxiety;Association Learning;autism spectrum disorder;Behavioral;behavioral phenotyping;Birth;bone;Brain;Brain region;brain size;cell type;Cells;Chemicals;Child;Chromatin;clinical development;Cognitive;Defect;Deposition;Development;Diagnosis;Disease;disease model;DNA;DNA Methylation;DNA Modification Methylases;Dose;Early Intervention;Enzymes;Epigenetic Process;Exploratory Behavior;feasibility testing;Future;Gene Expression;Gene Mutation;Gene Targeting;gene therapy;gene-targeted therapy;Genes;Genetic;Genetic Predisposition to Disease;Genetic Recombination;Genetic Transcription;genomic locus;Growth;Heterozygote;Human;human DNA;improved;in utero;in vivo;insight;Intervention;Knock-out;Life;loss of function mutation;Loss of Heterozygosity;Mediating;Methylation;Molecular;mouse genetics;mouse model;Mouse Strains;Mus;mutant;Mutant Strains Mice;Mutation;Nervous System;Neurocognitive;Neurodevelopmental Disorder;Neurons;Obesity;Patients;Pattern;Phenotype;Physiological;postnatal;postnatal development;public health relevance;Publishing;Reagent;Research Design;restoration;Rett Syndrome;Role;Site;Social Hierarchy;somatosensory;success;Tamoxifen;targeted treatment;Technology;Testing;Therapeutic;therapeutic development;Therapeutic Intervention;Therapeutic Research;Therapeutic Studies;Time;Tissues;tool;Transgenic Mice;Translating;Work

PROJECT_TITLE: Exploring Feasibility of Gene-Targeted Therapeutics for Epigenetic Neurodevelopmental Disorders

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunization;Infectious Diseases;Orphan Drug;Prevention;Rare Diseases;Rural Health;Vaccine Related

ORG_CITY: HOUSTON

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: RICE UNIVERSITY

ORG_STATE: TX

PHR: PROJECT NARRATIVE Despite the existence of a highly potent vaccine that can be administered after exposure, rabies still kills an estimated 59,000 people each year. 99% of these deaths occur in low- and middle-income countries due to both an increased exposure risk and the difficulty accessing rabies post-exposure prophylaxis (PEP), which typically requires 3 or 4 doses delivered over 1-2 weeks to be effective. To overcome healthcare accessibility challenges that disproportionally affect individuals in poor and rural communities, this project will develop a single-injection rabies vaccine for PEP in which microparticles engineered to exhibit delayed pulsatile release will mimic the antigen exposure kinetics known to be safe and effective, thereby conferring protection.

PI_NAMEs: MCHUGH, KEVIN JAMES (contact)

PROGRAM_OFFICER_NAME: PARK, EUN-CHUNG

PROJECT_TERMS: Affect;Africa;Antibody Response;Antibody titer measurement;Antibody-mediated protection;Antigens;Architecture;Area;Asia;barrier to care;Body Temperature;Caring;Case Fatality Rates;CD4 Positive T Lymphocytes;Cessation of life;Clinical;Communicable Diseases;controlled release;copolymer;Country;deamidation;Development;Disease;Dose;Dryness;Encapsulated;Engineering;Excipients;Exhibits;Exposure to;fabrication;Formulation;Glass;Glycolates;Goals;health care availability;Health Care Visit;Healthcare;Heating;Human;Immune response;Immunoglobulins;Improve Access;in vivo;Individual;Infrastructure;Injections;interest;Kinetics;low and middle-income countries;Methods;Modeling;Modification;Molecular Conformation;Molecular Weight;mortality;Nature;neutralizing antibody;Nucleosome Core Particle;particle;Patient Compliance;Persons;Pharmaceutical Preparations;Play;poor communities;prevent;preventable death;Process;Production;Prognosis;Property;prophylactic;Prophylactic treatment;Rabies;Rabies Vaccines;Rabies virus;Rattus;Recommendation;Refrigeration;Regimen;Risk;Role;rural area;Rural Community;Schedule;seal;standard of care;stressor;Survival Rate;Technology;Temperature;Time;Vaccination;vaccination schedule;vaccination strategy;vaccine delivery;Vaccines;Vial device;virtual;Virus;World Health Organization

PROJECT_TITLE: Leveraging Controlled Release to Create a Single-Injection Post-Exposure Prophylactic for Rabies

STUDY_SECTION: DBTD

STUDY_SECTION_NAME: Drug and Biologic Therapeutic Delivery Study Section[DBTD]


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

PHR: PROJECT NARRATIVE In this proposal, we will use artificial intelligence and natural language processing to extract social determinants of health, an area of high importance by healthcare systems who care for at risk patient populations. In contrast to prior work on SDH that focused on processing existing EHR data, we will use patient generated data in the form of a narrative. We will process this data using NLP and integrate it into the EHR as structured data that can be used to trigger clinical decision support to bring community resources to those in need.

PI_NAMEs: GOSS, FOSTER R (contact);ZHOU, LI

PROGRAM_OFFICER_NAME: TERAN, MARIO

PROJECT_TITLE: Using Large Language Models to identify social determinants of health to enhance healthcare services and equity

STUDY_SECTION: HITR

STUDY_SECTION_NAME: Healthcare Information Technology Research[HITR]


ADMINISTERING_IC: MD

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Liver Disease;Mental Health;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases

ORG_CITY: TUCSON

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: Public Health Relevance Statement Rates of non-alcoholic fatty liver disease (NAFLD) are high among Mexican-origin adults. Efforts to elucidate the complex interplays between acculturative stress, pro-inflammatory biomarkers, modifiable lifestyle behaviors (e.g., diet), and NAFLD are warranted. The proposed research will identify key pathophysiological and psychosocial mechanisms that will inform an R01 proposal for NAFLD stress management risk reduction intervention for Mexican-origin adults.

PI_NAMEs: GARCIA, DAVID O. (contact);MALDONADO, ADRIANA

PROGRAM_OFFICER_NAME: HERREN, OLGA MARINA

PROJECT_TERMS: Acceleration;Acculturation;Adult;Arizona;Attitude;Automobile Driving;Behavior;Behavioral;Belief;Biological Markers;biopsychosocial;Black Populations;burden of illness;C-reactive protein;cancer risk;carcinogenesis;Cause of Death;Chronic;Chronic stress;Cicatrix;Communities;Complex;Data;Development;Diet;Disease;disease disparity;Disease Management;Disparity;Environmental Risk Factor;experience;Fatty acid glycerol esters;Fibrosis;Future;Genetic;Goals;Health;High Prevalence;high risk population;indexing;Individual;Inflammation;Inflammatory;inflammatory marker;Inflammatory Response;innovation;Interleukin-6;Interleukins;Intervention;Intervention Trial;Interview;Knowledge;life span;Life Style;Link;Literature;Liver;Liver diseases;Low Prevalence;Malignant neoplasm of liver;Malignant Neoplasms;Mediating;Methods;Mexican;Mexico;Minority;minority health;Modeling;modifiable behavior;multidisciplinary;non-alcoholic fatty liver disease;Not Hispanic or Latino;Participant;Pathology;Pathway interactions;Patient Self-Report;perceived stress;Play;Population;Positioning Attribute;Prevalence;Primary carcinoma of the liver cells;Process;psychosocial;Questionnaires;Reporting;Research;Research Personnel;Risk;Risk Factors;Risk Reduction;Role;Sampling;Scientific Advances and Accomplishments;Severity of illness;socioenvironmental factor;Spanish;Stress;stress management;stressor;Structure;TNF gene;Work

PROJECT_TITLE: Acculturative stress and pro-inflammatory markers among Mexican-Origin adults with NAFLD

STUDY_SECTION: LHB

STUDY_SECTION_NAME: Lifestyle and Health Behaviors Study Section[LHB]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Cardiovascular;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Human Genome;Machine Learning and Artificial Intelligence;Pediatric;Pediatric Cancer;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases;Social Determinants of Health

ORG_CITY: MEMPHIS

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

PHR: PROJECT NARRATIVE Survivors of childhood cancer treated with anthracycline chemotherapy or chest-directed radiation are at substantially increased risk for developing cardiomyopathy that progresses to heart failure (HF), but this risk is disproportionately higher (2.5-fold) in African American (AA) survivors than Non-Hispanic Whites (NHWs). There is an urgent need to address this disparity by formulating novel solutions that support effective cardiovascular follow-up care for AA survivors. Leveraging the world’s largest sample of AA survivors of childhood cancer with exceptional clinical and genetic (next-generation sequencing) data, we propose to address this need by: (1) developing and independently validating race-specific clinical risk prediction models for cardiomyopathy; (2) identifying and assessing novel genetic cardiomyopathy predictors; and (3) contextualizing the performance of newly developed race-specific risk algorithms through extensive generalizability and comparative analyses, critically informing future efforts to integrate race-specific cardiomyopathy prediction models into survivorship care clinical workflows.

PI_NAMEs: IM, CINDY ;SAPKOTA, YADAV  (contact)

PROGRAM_OFFICER_NAME: COADY, SEAN

PROJECT_TERMS: Address;African American;Age;Algorithms;Anthracycline;Area;Biological Markers;cancer therapy;Cardiac;Cardiomyopathies;Cardiotoxicity;Cardiovascular Diseases;cardiovascular risk factor;Cardiovascular system;Caring;chemotherapy;Chest;childhood cancer survivor;Chronic;Clinical;clinical care;clinical risk;cohort;Collaborations;comparative;Consensus;cost;Data;Development;Diabetes Mellitus;Disparity;Echocardiography;Enrollment;ethnic disparity;ethnic minority;Ethnic Origin;Evaluation;exome sequencing;experience;Exposure to;Face;follow-up;Future;General Population;Genetic;genetic analysis;genetic predictors;Genetic Predisposition to Disease;Genetic Risk;Grant;Guidelines;Health;Heart failure;Hypertension;improved;Influentials;Informatics;inherited cardiomyopathy;innovation;Institution;Left Ventricular Dysfunction;Life;Life Style;machine learning prediction;Malignant Neoplasms;Minority Recruitment;model building;Modeling;Morbidity - disease rate;mortality;mortality risk;next generation sequencing;Not Hispanic or Latino;novel;Observational Study;Participant;Performance;personalized risk prediction;Persons;Phenotype;Policies;polygenic risk score;Population;precision medicine;Predictive Factor;predictive modeling;Prevalence;prevent;Publishing;Race;racial difference;racial disparity;racial minority;Radiation;Research Design;Risk;Risk Estimate;Risk Factors;risk prediction;risk prediction model;risk stratification;risk variant;Saint Jude Children's Research Hospital;Sampling;Scientist;social health determinants;statistical and machine learning;Statistical Models;Structure;Survivors;survivorship;Testing;tool;Training;training data;Treatment-Related Cancer;usability;Validation;Variant;whole genome;Work

PROJECT_TITLE: Developing and validating race-specific cardiomyopathy risk prediction models in African American survivors of childhood cancer

STUDY_SECTION: CHD

STUDY_SECTION_NAME: Cancer and Hematologic Disorders Study Section[CHD]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Childhood Obesity;Chronic Liver Disease and Cirrhosis;Complementary and Integrative Health;Dietary Supplements;Digestive Diseases;Genetics;Human Genome;Liver Disease;Microbiome;Nutrition;Obesity;Pediatric;Pregnancy;Prevention;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Women's Health Research

ORG_CITY: OKLAHOMA CITY

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PHR: PROJECT NARRATIVE Infants born to obese (OB) mothers are at higher risk for development of pediatric nonalcoholic fatty liver disease (NAFLD), with accelerated rates of obesity, diabetes and liver transplant. During OB pregnancy, maternal oxidative stress, metabolic inflammation and microbiome dysfunction affect placental function, as well as the offspring’s immune system, metabolic health and gut microbiome development. We seek to test the therapeutic potential of a dietary antioxidant that reduces inflammation in OB dams, pyrroloquinoline quinone (PQQ), to interrupt the transgenerational cycle of NAFLD in a highly translatable non-human primate, the olive baboon.

PI_NAMEs: JONSCHER, KAREN R (contact);MYERS, DEAN

PROGRAM_OFFICER_NAME: LOH, KATRINA SHUEH WEN

PROJECT_TERMS: 1 year old;Acceleration;Address;Adolescent;Adult;Affect;Anti-Inflammatory Agents;Antioxidants;Ascorbic Acid;Attenuated;Automobile Driving;Biochemical;Biological Markers;Blood flow;Bone Marrow;CD14 gene;Cells;Cesarean section;chemokine;Cholesterol;Chromatin;Clinical;cofactor;cytokine;Data;Defect;density;Development;Diabetes Mellitus;Diet;dietary antioxidant;Disease Marker;disease phenotype;Disease susceptibility;disorder risk;DNA Methylation;Doppler Ultrasound;Dose;Endotoxemia;Epigenetic Process;epigenomics;Exhibits;Feces;Female;fetal;Fetal Liver;fetal programming;Fetus;Food Supplements;Functional disorder;Genetic Transcription;Genus Hippocampus;Glucose;gut microbiome;gut microbiota;Health;Health Promotion;Hematopoietic stem cells;Hepatocyte;hepatoprotective;High Density Lipoproteins;high risk;Histopathology;Human;Hypoxia;Immune;Immune system;Immunofluorescence Immunologic;Immunophenotyping;immunoregulation;Impairment;improved;in utero;In Vitro;Infant;Inflammation;Inflammatory;Insulin;Interruption;Intervention;intravenous glucose tolerance test;Kupffer Cells;Large-Scale Sequencing;Link;lipid metabolism;lipidomics;Lipids;Liver;Liver diseases;liver transplantation;Low-Density Lipoproteins;Macrophage;maternal obesity;Measures;Mediator;Metabolic;Metabolic Diseases;Metabolism;Metagenomics;metaproteomics;meter;methylation pattern;microbial;microbiome;microbiome alteration;microbiome composition;MicroRNAs;Mitochondria;Modeling;Molecular;monocyte;Mus;next generation;non-alcoholic fatty liver disease;nonhuman primate;Nonpharmacologic Therapy;novel;Nutrient;obese mothers;Obesity;obesity in pregnancy;offspring;offspring obesity;Oxidative Stress;Oxidoreductase;Papio;Papio anubis;Pathway interactions;pediatric non-alcoholic fatty liver disease;pharmacologic;Phenotype;Placenta;Plasma;polyphenol;PQQ Cofactor;Pre-Clinical Model;Predisposition;Pregnancy;prevent;Primates;Production;programs;Property;Publishing;Recommendation;response;Rodent;Safety;Serum;Signal Transduction;single-cell RNA sequencing;Structure;Supplementation;System;systemic inflammatory response;Testing;Text;Therapeutic;therapeutic evaluation;therapeutically effective;Thiobarbituric Acid Reactive Substances;Tissues;transcriptome;transcriptome sequencing;transcriptomics;Translations;transmission process;trophoblast;Umbilical Cord Blood;Umbilical cord structure;Update;Venous;Very low density lipoprotein;Vulnerable Populations;western diet;Woman;Youth

PROJECT_TITLE: Evaluating PQQ for preventing maternal obesity-induced fetal programming of juvenile NAFLD in Papio anubis

STUDY_SECTION: NMHD

STUDY_SECTION_NAME: Nutrition and Metabolism in Health and Disease Study Section[NMHD]


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Mental Health;Rehabilitation;Sleep Research

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Insomnia is a leading cause of disability, and although the first-line treatment cognitive behavioral therapy for insomnia (CBT-I) is effective, many patients have residual insomnia symptoms, suggesting room for improvement. Passive body heating (PBH), which heats the body using infrared blankets, hot baths, or other heat sources, has been observed to improve sleep; yet to date, researchers have not tested whether adding PBH to CBT-I leads to greater treatment outcomes. We will therefore test the feasibility and acceptability of an integrated “mind” (CBT-I) and “body” (PBH) intervention for the treatment of insomnia, and will pilot RCT procedures using the integrated intervention in preparation for a future clinical efficacy trial.

PI_NAMEs: MASON, ASHLEY E. (contact)

PROGRAM_OFFICER_NAME: CHIDEYA-CHIHOTA, SEKAI RUTENDO

PROJECT_TERMS: 2 arm randomized control trial;acceptability and feasibility;Adult;American College of Physicians;arm;Bathing;Behavior Therapy;Behavioral;Biological Factors;Body Temperature;cardiometabolism;Clinical;Clinical Trials;Cognitive Therapy;cost effective;Data;Dependence;design;Devices;digital;disability;efficacy clinical trial;Enrollment;experience;falls;feasibility testing;Feedback;follow-up;Frequencies;Future;Goals;Health;Heating;Home;Hour;Household;improved;improvement on sleep;Individual;Infection;Intervention;Laboratories;light weight;Mental Depression;Mental Health;Mind;Mind-Body Intervention;mind/body;National Center for Complementary and Integrative Health;Nonpharmacologic Therapy;Participant;participant enrollment;Patients;Persons;pharmacologic;Pharmacotherapy;pilot test;post intervention;Predisposition;Preparation;Prevalence;Procedures;Process;programs;Protocols documentation;psychologic;Randomized;Recommendation;recruit;remote delivery;Research;Research Personnel;Residual state;Risk;Sauna;side effect;Skin;Skin Temperature;Sleep;Sleep Disorders;sleep onset;sleep quality;Sleeplessness;Source;Symptoms;Testing;Therapeutic heat application;Time;Treatment outcome;Vasodilation;Water

PROJECT_TITLE: Optimizing an integrated passive body heating and behavioral intervention for insomnia

STUDY_SECTION_NAME: Special Emphasis Panel[ZAT1 BH (01)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_NAME: SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

PHR: Project Narrative Recent evidence links synaptic dysfunction in Alzheimer’s disease (AD) to increased activity of the phosphatase STEP. Genetic deletion as well as pharmacological inhibition of STEP activity attenuates the cognitive impairment in an AD mouse model, validating STEP as a novel drug target for the treatment of AD. We propose to utilize an innovative fragment-based drug discovery approach to develop first-in-class potent, drug-like, and selective STEP proteolysis targeting chimeras (PROTACs), and to provide proof-of-concept for a STEP-targeted protein degradation strategy for the treatment of AD.

PI_NAMEs: COSFORD, NICHOLAS DAVID;TAUTZ, LUTZ  (contact)

PROGRAM_OFFICER_NAME: GROTHAUS, PAUL G

PROJECT_TERMS: 3xTg-AD mouse;Acids;Active Sites;Affinity;Allosteric Site;Alzheimer's Disease;Alzheimer's disease model;AMPA Receptors;Animals;Attenuated;Behavioral;Binding;Biochemical;Biochemical Markers;Biological Assay;blood-brain barrier crossing;blood-brain barrier penetration;Brain;Cell Membrane Permeability;Characteristics;Charge;Chemicals;Cognition;Cognitive;Cognitive deficits;Communities;Complex;Computer Models;Corpus striatum structure;Crystallography;Data;design;Deuterium;Digit structure;Disease;DNA;drug discovery;Drug Kinetics;drug metabolism;Drug Targeting;drug-like compound;Early treatment;Emerging Technologies;Endocytosis;Enzymes;Event;experimental study;Family member;Fragile X Syndrome;Functional disorder;Genetic;Glutamate Receptor;Glutamates;Goals;Human;Hydrogen;Impaired cognition;improved;in vivo;inhibitor;innovation;Knock-out;Knockout Mice;lead series;Length;Ligands;Link;MAPK3 gene;Mass Spectrum Analysis;Mitogen-Activated Protein Kinases;Modeling;Molecular Weight;mouse model;Mus;N-Methyl-D-Aspartate Receptors;Nature;Neurodegenerative Disorders;Neurons;neuropsychiatric disorder;new therapeutic target;novel;novel therapeutic intervention;novel therapeutics;Organism;p38 Mitogen Activated Protein Kinase;Parkinson Disease;Pharmaceutical Chemistry;Pharmaceutical Preparations;Pharmacodynamics;pharmacologic;phosphatase inhibitor;Phosphoric Monoester Hydrolases;Phosphotransferases;Physiological;postsynaptic;preclinical development;preclinical study;Presynaptic Terminals;Property;Protac;protein degradation;Protein Dephosphorylation;Protein Tyrosine Phosphatase;Proto-Oncogene Proteins c-fyn;Reaction;receptor;Reporting;Research;Safety;Schizophrenia;screening;Series;Signal Transduction;Site;small molecule;Specificity;Structure-Activity Relationship;Study models;Sulfhydryl Compounds;Surface;Synapses;synaptic function;targeted treatment;Technology;Testing;Therapeutic;tool;Toxic effect;Transgenic Mice;treatment strategy;ubiquitin-protein ligase;validation studies;X-Ray Crystallography

PROJECT_TITLE: Fragment-based discovery of STEP modulators in Alzheimer's disease

STUDY_SECTION: DMPB

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology B Study Section[DMPB]


ED_INST_TYPE: UNIVERSITY-WIDE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

ORG_CITY: ATLANTA

ORG_NAME: GEORGIA INSTITUTE OF TECHNOLOGY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Type 1 diabetes (T1D) is a chronic, debilitating disease that arises from the autoimmune destruction of insulin- producing β-cells located within pancreatic islets. Pancreatic islet transplantation has shown promise as a potential T1D treatment but is severely limited in clinical settings due to instant blood-mediated inflammatory reaction and delayed re-vascularization of transplanted islets within the intrahepatic site. The objective of this project is to engineer a synthetic biomaterial platform to induce successful vascularization and engraftment of islets in the subcutaneous space, an attractive alternative transplant site with high clinical potential for cell therapies to treat T1D.

PI_NAMEs: QUIZON, MICHELLE  (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Affect;Allogenic;Animal Model;Animals;arm;Autoimmune Diseases;autoimmune pathogenesis;Beta Cell;Biocompatible Materials;Blood;Blood Coagulation Factor;Blood Glucose;blood glucose regulation;Blood Vessels;Calcium Signaling;Cardiovascular Diseases;Cell Therapy;Cells;Cessation of life;Chronic;Clinical;Collagen;complement system;Data;delivery vehicle;Development;Devices;Diabetes Mellitus;diabetic;diabetic rat;Disease;Dose;Encapsulated;Endothelial Cells;Engineering;Engraftment;ethylene glycol;Extrahepatic;Family suidae;Fatty acid glycerol esters;Formulation;Foundations;Functional disorder;Future;Gel;Glucose;Glucose tolerance test;glycemic control;graft function;Growth;Healthcare;Hepatic;Hour;Hydrogels;Hypoxia;immunomodulatory strategy;Immunosuppression;Implant;In Vitro;in vivo;Inflammatory;Infusion procedures;Injectable;innovation;Insulin;Insulin-Dependent Diabetes Mellitus;intrahepatic;islet;Islets of Langerhans;Islets of Langerhans Transplantation;Kinetics;Maleimides;Mediating;Metabolic;Microfluidic Microchips;Modeling;Monitor;Neonatal;neovascularization;Neuropathy;Newly Diagnosed;non-diabetic;novel;novel strategies;Nutrient;Omentum;Organ;Outcome;Patients;Perfusion;Persons;Platelet Activation;Portal vein structure;Prevalence;Procedures;Rattus;Reaction;release factor;Research;Retrieval;revascularization;Rodent;Rodent Model;scaffold;screening;Site;Solid;subcutaneous;Technology;Testing;Time;Tissues;Transplant Recipients;Transplantation;Validation;vascular bed;Vascular Endothelial Growth Factors;Vascularization;Vasculogenic;Work

PROJECT_TITLE: Synthetic Hydrogels for Islet Vascularization and Engraftment


NIH_SPENDING_CATS: Clinical Research;Contraception/Reproduction;Health Services;Patient Safety;Prevention;Telehealth;Women's Health Research

ORG_DEPT: OBSTETRICS & GYNECOLOGY

PHR: Project Narrative The COVID-19 pandemic brought about an increase in the use of telehealth for sexual and reproductive health services. However, the role of follow-up protocols in identifying adverse events among telehealth patients is not well understood. This study will evaluate the performance of telehealth sexual and reproductive health follow- up protocols in identifying adverse events. These results will inform the development of telehealth clinical protocols that are cost-effective, patient-centered, and safe.

PI_NAMEs: KOENIG, LEAH REN-AI (contact)

PROGRAM_OFFICER_NAME: POPKIN, RONNA

PROJECT_TERMS: abortion;Address;Adverse event;adverse event monitoring;adverse event risk;Blood Transfusion;California;career;Caring;Childbirth;Clinical;Clinical Protocols;Clinical Services;Cohort Studies;Contraceptive methods;cost effective;cost effectiveness;Cost Savings;COVID-19 pandemic;Data;Data Analyses;Data Collection;data management;Data Set;Data Sources;design;Development;Diagnosis;Doctor of Philosophy;doctoral student;efficacy study;Electronic Health Record;Ensure;Epidemiology;Evaluation;Event;experience;Fellowship;follow-up;Foundations;Future;Goals;health care delivery;Health Personnel;Health Services;Health Services Research;Health Surveys;Health system;Healthcare;Home;Hospitalization;improved;Incidence;Incomplete spontaneous abortion;Individual;innovation;insight;Knowledge;Mentors;Methodology;Methods;Mission;Monitor;National Institute of Child Health and Human Development;National Research Service Awards;Outcome;Participant;patient oriented;Patient Outcomes Assessments;Patient Participation;patient safety;patient screening;patient subsets;Patient-Centered Care;Patient-Focused Outcomes;Patients;Performance;Persons;Pharmaceutical Preparations;Positioning Attribute;Pregnancy;Probability;Process;Proliferating;prospective;Protocols documentation;Provider;remote screening;reproductive;Reproductive Health;Reproductive Health Services;Reproductive Process;Research;Research Personnel;Role;Safety;safety study;Schedule;secondary analysis;Sepsis;service delivery;Services;sexual and reproductive health;Sexually Transmitted Diseases;skills;Statistical Methods;Surveys;telehealth;Testing;Time;Training;United Kingdom;United States;United States Food and Drug Administration;Woman;Work

PROJECT_TITLE: Protocols to ascertain adverse events after telehealth sexual and reproductive health services

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F18-D(20)L]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: MINNEAPOLIS

ORG_NAME: MINNEAPOLIS VA  MEDICAL CENTER

ORG_STATE: MN

PHR: Enhancing access and use of evidence-based tobacco cessation treatments and eliminating tobacco-related health disparities are top national and VA health services priorities. The prevalence of tobacco use is greater among Veterans compared to non-Veterans. From 2010-2015, 29% of women and 21% of male Veterans reported current cigarette smoking. Evidence-based cessation treatments (EBCTs) such as, tobacco quitlines, behavioral counseling, and pharmacotherapy, are greatly underutilized by Veteran smokers. The role of social network influences and social support on successful smoking cessation is established. This project is innovative for evaluating social support networks as a proactive outreach approach to enhance cessation treatment utilization among Veteran smokers. We will conduct a pragmatic randomized controlled trial (RCT) within the national VHA health system to evaluate the effectiveness of a social support intervention compared with a control condition on utilization of EBCTs among a national sample of VHA-enrolled smokers.

PI_NAMEs: FU, STEVEN  (contact)

PROJECT_TERMS: Address;Adoption;Adult;Behavioral;Biochemical;cigarette smoking;Collaborations;Communication;Communities;comparison intervention;Counseling;Databases;Development;effectiveness evaluation;effectiveness trial;efficacy trial;Electronic Health Record;Enrollment;evidence base;Family;Family member;follow-up;Fostering;Foundations;Friends;Future;Gender;General Population;group intervention;health disparity;Health Services;Health Services Accessibility;Health system;Healthcare;implementation evaluation;implementation outcomes;innovation;interest;Intervention;intervention effect;Literature;male;men;Methodology;motivational enhancement therapy;non-smoking;Outcome Study;outreach;Participant;patient oriented;peer support;Persons;Pharmacotherapy;Population;Prevalence;process evaluation;Professional counselor;programs;Public Health;quitline;Randomized;Randomized, Controlled Trials;Readiness;Recommendation;recruit;Reporting;Research;Resources;Role;Sample Size;Sampling;Smoker;Smoking;smoking abstinence;smoking cessation;Smoking Status;Smoking treatment;social;Social Network;Social support;telephone coaching;theories;Tobacco;tobacco cessation intervention;Tobacco use;tobacco user;trial enrollment;Veterans;Woman;Women's Health;Work;Writing

PROJECT_TITLE: Veteran Social Support Intervention for Enhancing Smoking Treatment Utilization and Cessation

STUDY_SECTION_NAME: HSR-2 Behavioral, Social, and Cultural Determinants of Health and Care[HSR2]


PHR: Patients who complete prolonged exposure and cognitive processing therapy, the treatments for posttraumatic stress disorder (PTSD) with the most empirical support, continue to express a need for mental health treatment. A therapist-assisted self-management program for patients who have completed one of these two treatments and achieved symptom improvement has the potential to meet patients' stated treatment needs, maintain or build upon their PTSD symptom reductions, increase their confidence in managing their symptoms, and reduce the number of mental health appointments that they need to attend. Further, reducing the number of mental health sessions attended by completers of these time and resource intensive psychotherapies will increase the likelihood that their implementation in regular-practice clinics will be maintained.

PI_NAMEs: KEHLE-FORBES, SHANNON M. (contact)

PROJECT_TERMS: Appointment;Area;Behavior;Caring;Clinic;Clinical;Cognitive;cohort;Data;Dependence;design;effective therapy;Effectiveness;empowerment;Evaluation;experience;feasibility testing;feasibility trial;Fright;future implementation;Goals;health care service utilization;Health Personnel;health service use;Health Services Accessibility;Health system;Hour;Hybrids;implementation barriers;impression;Improve Access;improved;improved outcome;innovation;interest;Intervention;Interview;Learning Skill;Maintenance;Manuals;Measures;meetings;Mental Depression;Mental Health;Mental Health Services;Methodology;Methods;Modeling;Outcome;Outpatients;Participant;Patient Discharge;Patient Self-Report;Patient-Focused Outcomes;Patients;Perception;Personal Satisfaction;post-trauma;Post-Traumatic Stress Disorders;Preparation;primary outcome;Probability;Provider;Psychotherapy;Randomized;Randomized, Controlled Trials;reduce symptoms;Relapse;Reporting;Resources;Role;Sample Size;satisfaction;Self Efficacy;Self Management;Self Perception;self-management program;service utilization;Services;Signal Transduction;Site;Structure;success;Suicide prevention;symptom management;symptomatic improvement;Symptoms;Time;Trauma;treatment as usual;Treatment Effectiveness;Treatment outcome;treatment planning;Veterans;Work;work-study

PROJECT_TITLE: Empowering Veterans to Self-Manage PTSD Symptoms Following Completion of Trauma-Focused Therapy

STUDY_SECTION_NAME: HSR-4  Mental and Behavioral Health[HSR4]


ADMINISTERING_IC: CK

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: National Center for Emerging and Zoonotic Infectious Diseases

ORG_CITY: GAINESVILLE

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: The goal of the CDC Southeastern Center of Excellence in Vector-Borne Diseases: Gateway Program (SECVBD) is to maintain our established, comprehensive, applied, and basic research program that fully addresses the epidemiological triad to underpin our understanding of vector-borne disease transmission in the continental U.S. and territories. The SECVBD’s primary Public Health Outcomes include: (i) Diversity, equity, and inclusion (DEI) in accessing training opportunities in public health entomology (PHE); (ii) Higher resolution of tick vector distribution and tick-borne illness (TBI) prevalence in vector populations; (iii) Enhanced vector surveillance and control operations; (iv) Strengthened PHE Community of Practice in the Southeastern U.S. and U.S. Territories in the Caribbean; (v) Exploration of strategies for proactive vector control; (vi) New delivery modalities for novel chemical active adulticides against insecticide-resistant mosquitoes; and (vii) Socio- behavioral modifications viz. clinical TBI diagnoses, personal protective measures, and adoption of tick- encounter reduction technology.

PI_NAMEs: DINGLASAN, RHOEL DAVID RAMOS (contact)


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Emerging Infectious Diseases;Genetics;Infectious Diseases;Lung;Orphan Drug;Precision Medicine;Rare Diseases;Tuberculosis

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

PHR: Project Narrative The success of the new anti-tuberculosis drug bedaquiline for the treatment of drug-resistant tuberculosis has raised hopes for shorter and more tolerable and effective treatment regimens than previously available, though outcomes with programmatic use of some bedaquiline-based regimens are unknown. South Africa has implemented bedaquiline-based, injectable-free regimens for the treatment of drug-resistant tuberculosis, but poor treatment response, defined by positive cultures for Mycobacterium tuberculosis during treatment, and poor treatment outcomes, are a concern. In the proposed studies, we aim to determine the clinical, pharmacokinetic, and mycobacterial genotypic and phenotypic predictors of programmatic poor treatment response and outcomes in South Africa, which will allow targeted interventions among high risk individuals.

PI_NAMEs: VAN DER HEIJDEN, YURI F. (contact)

PROGRAM_OFFICER_NAME: LAUGHON, BARBARA E

PROJECT_TERMS: Address;Adherence;Affect;Antimicrobial Resistance;Bacteriology;Blood;Blood specimen;Caring;Case/Control Studies;Cause of Death;Cessation of life;Clinical;Clinical Data;Clinical Trials;Communicable Diseases;Companions;Data;Diagnosis;DNA Sequence Alteration;Dose;Drops;Drug Kinetics;Drug Modelings;Drug resistance;Drug resistance in tuberculosis;effective therapy;electronic registry;Electronics;follow-up;Genes;genome sequencing;Genotype;Half-Life;Health;high risk;high risk population;improved;Individual;Infrastructure;Injectable;insight;Intervention;isoniazid;Laboratories;Levaquin;Linezolid;Measures;Methods;Minimum Inhibitory Concentration measurement;Modeling;Molecular Epidemiology;multidisciplinary;Mutation;mycobacterial;Mycobacterium tuberculosis;novel;novel strategies;novel therapeutics;Observational Study;Oral;Outcome;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;pharmacokinetic model;pharmacologic;Phenotype;Policies;Population;Predictive Factor;predictive modeling;Predisposition;programs;Province;public health priorities;Pyrazinamide;Regimen;relapse risk;Reporting;Research;Resistance;Resources;Rifampicin resistance;Rifampin;Risk;South Africa;South African;Specimen;Sputum;success;System;Testing;Time;Training;treatment duration;Treatment Failure;Treatment outcome;Treatment Protocols;treatment response;treatment stratification;Tuberculosis;Tuberculosis diagnosis;tuberculosis drugs;tuberculosis treatment;Variant;whole genome

PROJECT_TITLE: Poor Treatment Response and Outcomes in Bedaquiline-Based Treatment Regimens for Drug-Resistant Tuberculosis in South Africa

STUDY_SECTION: CRFS

STUDY_SECTION_NAME: Clinical Research and Field Studies of Infectious Diseases Study Section[CRFS]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: PROJECT NARRATIVE – GREAT PLAINS CENTER FOR AGRICULTURAL HEALTH (OVERALL) The Great Plains Center for Agricultural Health is a regional center dedicated to conducting research and providing outreach to protect the health and safety of agricultural workers across our nine-state upper Midwest region. Our research will identify risk factors, develop technology, and evaluate interventions to reduce the burden of injury and disease associated with risk factors relevant to our region’s intensive row crop and livestock production activities -- vehicle vibration, roadway hazards, indoor air quality, and cognitive declines in older workers as well as persistent safety hazards. We will share lessons learned by building expertise throughout the region by developing evidence-based curricula targeting multiple audiences (e.g., youth, college, and healthcare), communicating through storytelling using traditional and innovative multi-media platforms, and building new partner networks to collaboratively influence safety and health perceptions and behaviors of farm workers.

PI_NAMEs: ANTHONY, THERESA RENEE (contact)


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Complementary and Integrative Health;Mental Health;Neurosciences;Pediatric

ORG_CITY: CAMBRIDGE

ORG_DEPT: BIOLOGY

ORG_NAME: HARVARD UNIVERSITY

PHR: Project Narrative Attachment bonds between children and family dogs can result in positive therapeutic outcomes in both typical and clinical populations, including reduction of child stress and anxiety when the dog is present. These outcomes are likely mediated by the strength of the child-dog bond, so identifying the biological mechanisms that support the formation of strong, successful bonds is foundational to maximizing these therapeutic effects. The current proposal longitudinally examines the development of behavioral, neural, and endocrine mechanisms that underlie the stress- and anxiety-reducing effects of social bonds between children and their pet dogs.

PI_NAMEs: REILLY, OLIVIA TOMEO (contact)

PROGRAM_OFFICER_NAME: ESPOSITO, LAYLA E

PROJECT_TERMS: Adoption;Adult;Amygdaloid structure;Anesthesia procedures;Animals;Anti-Anxiety Agents;Anxiety;anxiety reduction;Area;Behavior;behavior test;Behavioral;Bilateral;Biological;biological adaptation to stress;Brain;Canis familiaris;career;Child;Child Behavior;Child Development;Child Health;Child Welfare;cingulate gyrus;Clinical;companion animal;comparative;Data;Data Analyses;Data Collection;Development;Dog family;Dorsal;Emotions;Endocrine;Endocrinology;Environment;Feeling;Foundations;Friends;Functional Magnetic Resonance Imaging;functional MRI scan;Future;Glucocorticoids;Goals;Health;Heart Rate;Hippocampus;Hormonal;Hormones;Human;Hydrocortisone;Image;improved;Insula of Reil;Learning;Link;Loneliness;Measures;Mediating;Methodology;Methods;Mission;National Institute of Child Health and Human Development;neural;neuroimaging;Neurologic;Neuropeptides;Neurosciences;Odors;offspring;Outcome;Ownership;Oxytocin;Parents;Physical activity;physically handicapped;Physiological;Population;Positioning Attribute;Prefrontal Cortex;Primates;Process;Psyche structure;Research;response;Rest;Rewards;saliva sample;Salivary;salivary assay;Sampling;Service animal;skills;social;social attachment;Social Development;Social support;Standardization;Stress;stress management;stress reduction;success;Techniques;Testing;Therapeutic;Therapeutic Effect;Therapeutic Uses;therapy outcome;Time;Training;Visual impairment

PROJECT_TITLE: A child's best friend: Behavioral, neural, and endocrinological mechanisms of longitudinal social bond formation and stress buffering effects in children and pet dogs


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Genetics;Neurosciences;Sleep Research

ORG_CITY: PHILADELPHIA

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Narrative Sleepiness is a common but poorly-understood symptom of sickness. This project exploits powerful genetic tools in a round worm to understand a signal that triggers sickness sleep.

PI_NAMEs: RAIZEN, DAVID MENASSAH (contact)

PROGRAM_OFFICER_NAME: HE, JANET

PROJECT_TERMS: Acceleration;Address;Adult;Affect;Afferent Neurons;Animals;arm;Auxins;Behavior;Behavior Control;Behavioral;Biological;Biological Models;Caenorhabditis elegans;candidate identification;Cells;Cellular Stress;Chemicals;Chronic;Clinical Treatment;cytokine;Data;Defect;deprivation;Diagnostic;Disabling;Drowsiness;environmental stressor;Epidermal Growth Factor;Epidermal Growth Factor Receptor;feeding;Fishes;fly;Functional disorder;Future;gene function;gene product;Genes;Genetic;genetic manipulation;Genetic Transcription;genome-wide;Goals;Heat-Shock Response;Human;Impairment;Induced Neurons;Infection;Inflammatory;interest;Invertebrates;Mammals;Methods;mortality;Motivation;Movement;Mus;Mutagenesis;Mutagens;mutant;Mutate;Mutation;Nematoda;Neurons;Neurosecretory Systems;paracrine;Peptides;Peripheral;Positioning Attribute;prevent;programs;Receptor Signaling;Recovery;Regulation;Signal Transduction;Signaling Molecule;Site;Sleep;sleep behavior;Sleep Deprivation;social;Source;Stream;Stress;Symptoms;System;Testing;Time;tool;Translating;Ultraviolet Rays;Uncertainty;Vertebrates;Viral;Virus Diseases;whole genome;Withdrawal

PROJECT_TITLE: Mechanistic studies of sickness sleep

STUDY_SECTION: BNRS

STUDY_SECTION_NAME: Behavioral Neuroendocrinology, Neuroimmunology, Rhythms, and Sleep Study Section [BNRS]


ORG_CITY: ANN ARBOR

ORG_NAME: VETERANS HEALTH ADMINISTRATION

ORG_STATE: MI

PHR: The proposed research is relevant to Veteran health because it focuses on improving how national prevention guidelines, which strongly influence preventive care practice in the VA, determine who is eligible for evidence- based prevention. Recent research shows that, for a diverse population, using multivariable prediction to estimate an intervention’s “individualized” net benefit, and to develop what are called tailored recommendations, is a promising alternative to conventional guideline recommendations. Once novel guideline-development methods are developed in this proposal (i.e., best practices for developing and examining tailored recommendations in guidelines), there is the potential for a significant advance toward more nuanced prevention guidelines that, in many cases, could avert more deaths, improve life-year gains, reduce racial disparities, and support more patient-centered shared decision making. Thus, the proposed research supports VA’s mission to advance scientific knowledge to help Veterans live longer, healthier lives.

PI_NAMEs: CAVERLY, TANNER J (contact)

PROJECT_TERMS: Address;Adoption;Affect;Age;Anti-Hypertensive Agents;blood lipid;Blood Pressure;cardiovascular disorder prevention;Cardiovascular system;Caring;Case Study;Cessation of life;Clinical;clinical decision support;comorbidity;comparative;Decision Making;design;Development;Disparity;disparity reduction;Eligibility Determination;Equity;Ethics;Event;evidence base;Exclusion;experience;Family;Future;geographic disparity;Goals;Guidelines;Health;Heterogeneity;improved;Individual;individualized prevention;Influentials;innovation;Intervention;Interview;Knowledge;Lead;Life;Life Expectancy;Lipids;lung cancer screening;Measures;medically underserved;method development;Methods;military veteran;Minority Groups;minority patient;Mission;Modeling;models and simulation;novel;Outcome;outcome disparities;patient oriented;Patients;personalized approach;personalized care;Population Heterogeneity;Prevention;Prevention Guidelines;Preventive care;Preventive service;Process;programs;Public Health;Publications;Race;racial disparity;Recommendation;Recording of previous events;Research;Research Support;Risk;Risk Factors;Scientific Advances and Accomplishments;Screening for cancer;shared decision making;simulation;Smoking;Structure;Study models;support tools;Target Populations;Veterans;Work

PROJECT_TITLE: Redesigning Preventive Care Recommendations for Diverse Populations of Veterans

STUDY_SECTION_NAME: HSR-1 Health Care and Clinical Management[HSR1]


ORG_CITY: BRONX

ORG_NAME: JAMES J PETERS VA  MEDICAL CENTER

ORG_STATE: NY

PHR: Veterans with Spinal Cord Injury or Disorders (SCI/D) have complex medical and caretaker treatment needs that put them at elevated risk for negative medical and mental health outcomes, including mortality. Veterans with SCI/D are also at higher risk for COVID-19 and disproportionately experience hardship from disrupted and deferred health services during the COVID-19 pandemic including loss of caregiver support and ancillary but essential services such as wheelchair repair and transportation. Many in this population have limited mobility so existing social isolation was exacerbated. The proposed project aims to identify the impact of the pandemic on the health service delivery, access to essential resources, physical and mental health consequences, and death among Veterans with SCI/D. The goal of this research is to produce knowledge that can be used by the SCI/D National Program Office to create resources to improve health services for Veterans with SCI/D during future emergency events and ultimately improve the health and mortality risk of this vulnerable population.

PI_NAMEs: FINLAY, ANDREA K;GALEA, MARINELLA  (contact)

PROJECT_TERMS: Address;Awareness;Bladder;Businesses;care delivery;care systems;Caregiver support;Caregivers;Caring;Cessation of life;Chronic;Chronic Disease;Classification;Communities;community-level factor;Complex;COVID-19;COVID-19 impact;COVID-19 mortality;COVID-19 pandemic;COVID-19 risk;COVID-19 test;Data;Decision Making;decubitus ulcer;Development;disability;Disasters;Disease;Disease Management;Economics;emergency preparedness;Emergency response;Emergency Situation;Emotional;Enrollment;Evaluation;Event;experience;Focus Groups;food insecurity;Future;Goals;Guidelines;Health;health care delivery;health care service;Health Personnel;health service use;Health Services;Health Services Accessibility;Health Services Administration;Health Services Needs;Healthcare;high risk;Home;Housing;Hurricane;Improve Access;improved;Incidence;Individual;inpatient service;International;Intestines;Knowledge;Learning;Measures;Medical;medical specialties;Mental Depression;Mental Health;Methodology;Methods;Modeling;Morbidity - disease rate;mortality;mortality risk;Natural Disasters;Nature;New York;Newly Diagnosed;operation;Outcome;pandemic disease;pandemic impact;patient home care;Patients;Pattern;Performance;Persons;physical conditioning;Policies;Population;Primary Care;primary care practice;Productivity;programs;Provider;psychosocial outcome;Quality of life;Registries;repaired;Research;research and development;Resource Allocation;Resources;response;Risk;SARS-CoV-2 positive;screening;Self-Help Devices;Services;Site;Social Distance;Social isolation;Source;Spinal cord injury;stay-at-home order;Stress;Surveys;System;Systems Integration;telehealth;Time;Transportation;Treatment/Psychosocial Effects;United States;Variant;Veterans;Veterans Health Administration;Vulnerable Populations;Wheelchairs;World Health Organization

PROJECT_TITLE: Disruption of Health Services: The Impact of COVID-19 on Veterans with SCI/D

STUDY_SECTION_NAME: HSR-5 Health Care System Organization and Delivery and Women's Health[HSR5]


NIH_SPENDING_CATS: Infectious Diseases;Lung;Neurosciences;Physical Injury - Accidents and Adverse Effects;Pneumonia;Pneumonia and Influenza;Prevention;Regenerative Medicine;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative Hospital-acquired pneumonia is predictive of enhanced disability and mortality after SCI; whereas pneumonia qualifies as a potent and targetable outcome-modifying factor, orthodox antibiotic treatments were ineffective to prevent infections or protect outcome at risk. By selecting a mechanistic approach supported by recent data from our lab, we will focus on one goal: Reducing infection susceptibility by restoring immune function. If successful, data from this grant proposal will inform the development of more effective non-antibiotic treatments for immune compromised SCI patients

PI_NAMEs: SCHWAB, JAN  (contact)

PROGRAM_OFFICER_NAME: BAMBRICK, LINDA LOUISE

PROJECT_TERMS: Acute;Acute Pneumonia;Address;Adrenal Gland Hyperfunction;Adrenal Glands;adverse outcome;Anatomy;Anti-Infective Agents;Antibiotic Resistance;Antibiotic Therapy;Antibiotics;Applications Grants;Atrophic;Autonomic Dysfunction;Bacteria;Bacterial Pneumonia;Biological Assay;Biological Markers;Catecholamines;Cause of Death;Cells;Cessation of life;Characteristics;cholinergic;Clinical;clinical application;clinically relevant;Colony-forming units;Cre lox recombination system;Data;Development;disability;Disinhibition;Drug Delivery Systems;drug repurposing;Dysautonomias;Endocrine;Experimental Models;experimental study;Failure;FDA approved;Functional disorder;gabapentin;Ganglia;Genetic;Goals;gut dysbiosis;Host Defense;Immune;immune function;Immune system;immune system function;immunodeficiency;Immunologic Deficiency Syndromes;Immunosuppression;Impairment;improved;in vivo;Individual;Infection;Infection prevention;Injury;insight;Intervention;Lesion;Life;Lung;Lymphocyte Count;Lymphoid Tissue;Lymphopenia;Methodology;modifiable risk;Molecular Target;mortality;Multicenter Studies;Nerve;Neurologic;neurological recovery;Neurons;neuroregulation;Neurosecretory Systems;Nosocomial pneumonia;novel;Outcome;Pathogenesis;Pathologic;Patients;Pharmaceutical Preparations;pharmacologic;Pneumonia;Predisposition;presynaptic;prevent;Prevention;Qualifying;Recovery;Recovery of Function;Reflex action;Regimen;restoration;Risk;Risk Factors;Sepsis;septic;Series;Severities;Site;Spinal;Spinal cord injury;Spinal cord injury patients;Spleen;Streptococcus pneumoniae;Sympathetic Nerve Block;Synaptic Transmission;T-Lymphocyte;Technology;Testing;Thymus Gland;Tissues;transmission process;treatment strategy;voltage;Whole Blood

PROJECT_TITLE: Reducing Infection Susceptibility by Immune Function Restoration in Spinal Cord Injury

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


PHR: Project Narrative The aggregation of proteins such as α-Synuclein into fibrillar aggregates plays a pivotal role in the progression of Parkinson's Disease and related neurodegenerative disorders. The proposed research will study the molecular and cellular factors related to cell-to-cell transmission of toxic α-Synuclein species to gain insight into the mechanism of disease propagation.

PI_NAMEs: RHOADES, ELIZABETH  (contact)

PROGRAM_OFFICER_NAME: SARRAF, SHIREEN AKHAVAN

PROJECT_TERMS: Acetylation;Affinity;alpha synuclein;Automobile Driving;Binding;Brain;Cell membrane;Cells;Characteristics;Coculture Techniques;Communities;Complex;Data;Deposition;design;Disease;extracellular;Fluorescence Resonance Energy Transfer;Future;Genes;Global Change;Glycoproteins;glycosylation;Goals;Grain;In Vitro;in vivo;Inherited;insight;Kinetics;Lewy Bodies;Link;live cell imaging;Mass Spectrum Analysis;Measures;Mediating;Mediator;Membrane Proteins;Modeling;Modification;Molecular;Molecular Structure;monomer;mutant;N-terminal;Neurodegenerative Disorders;Neurons;novel;Parkinson Disease;Pathologic;Pathology;Persons;pharmacologic;Physiological;Play;Polysaccharides;Post-Translational Protein Processing;presynaptic;Process;protein aggregation;Proteins;receptor;Reporting;Research;Resolution;Role;Single Nucleotide Polymorphism;small molecule;small molecule therapeutics;Specificity;Structure;success;Surface;Synapses;synaptic function;synaptogenesis;synergism;System;Testing;Therapeutic;therapeutically effective;transmission process;uptake;Variant;Work

PROJECT_TITLE: Structural basis and physiological consequences of alpha-Synuclein binding to neurexin 1beta


NIH_SPENDING_CATS: Aging;Cancer;Cancer Genomics;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Precision Medicine;Prevention;Prostate Cancer;Racial and Ethnic Minority Health Research;Urologic Diseases

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

ORG_STATE: CA

PHR: Project Narrative In this project, we will conduct genome-wide discovery efforts to identify variants and genes that contribute to risk of prostate cancer and aggressive disease in men of European, African, Asian and Latino ancestry. We expect findings from this study will make a major contribution to our understanding of genetic susceptibility to prostate cancer and will have widespread applicability and significance, leading to better risk models to more accurately predict a man's risk of developing prostate cancer.

PI_NAMEs: CONTI, DAVID V;HAIMAN, CHRISTOPHER ALAN (contact)

PROGRAM_OFFICER_NAME: DAEE, DANIELLE L

PROJECT_TERMS: African;African American;African American population;African ancestry;Age;Asian;Asian ancestry;Asian population;Biological;Biological Assay;Biology;case control;causal variant;cohort;Data;design;Disease;ethnic difference;Ethnic Origin;Ethnic Population;European;European ancestry;Freezing;Gene Expression;Genes;Genetic;genetic association;Genetic Databases;Genetic Predisposition to Disease;Genetic Risk;Genetic study;Genetic Variation;genome wide association study;genome-wide;Germ Lines;Histologic;improved;Incidence;innovation;insertion/deletion mutation;Latino;Malignant neoplasm of prostate;man;Maps;Measures;Medical;men;Modeling;multi-ethnic;novel;Phenotype;Physicians;polygenic risk score;Population;Prostate;prostate cancer risk;Race;racial difference;racial diversity;racial population;Regulator Genes;Regulatory Element;Risk;Risk Marker;risk prediction;risk variant;RNA Sequences;Sample Size;Sampling;Scanning;screening;secondary analysis;Signal Transduction;Specimen;Susceptibility Gene;Testing;Tissues;Trans-Omics for Precision Medicine;Transcript;transcriptome;transcriptome sequencing;transcriptomics;Validation;Variant;whole genome;Work

PROJECT_TITLE: Multiethnic GWAS and TWAS to Inform Risk Prediction for Prostate Cancer

STUDY_SECTION: CHSB

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology B Study Section[CHSB]


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: CITY OF INDUSTRY

ORG_NAME: PUBLIC HEALTH FOUNDATION ENTERPRISES

PHR: Trans women are highly impacted by HIV in Nepal with an HIV prevalence 22 times greater than in the general population. We found that only half of trans women have been tested for HIV recently and HIV care engagement is low relative to national targets. Building on recently-completed NIH funded research, we propose to pilot a multi-level intersectional stigma reduction intervention to increase HIV testing and engagement in HIV care among trans women in Nepal.

PI_NAMEs: MEEK, ERIN CATHERINE (contact)

PROGRAM_OFFICER_NAME: BANSAL, GEETHA PARTHASARATHY

PROJECT_TERMS: Address;Adherence;AIDS prevention;Alcohol consumption;Asia;Attitude;care delivery;Caring;Categories;Collaborations;Communities;COVID-19;Data;design;Diamond;Discrimination;Distress;Economics;Education;Employment;empowerment;evidence base;experience;Failure;forging;Frequencies;Funding;Gender;gender minority group;General Population;Geography;Health;HIV;HIV risk;HIV-2;Home;Human immunodeficiency virus test;improved;Income;Individual;innovation;internalized stigma;Interruption;Intervention;Knowledge;low and middle-income countries;low income country;marginalized population;Media Campaign;Modeling;Nepal;Nongovernmental Organizations;Occupations;Outcome;Participant;Persons;Pharmaceutical Preparations;physical assault;Policies;Population;Population Study;Positioning Attribute;Prevalence;prevent;Prevention;Prevention program;prevention service;Psyche structure;Reduce health disparities;Research;Research Personnel;response;self testing;Services;sex;sexual assault;sexual minority group;Sexual Partners;sexual risk behavior;Site;social media;social stigma;Social support;Societies;Stigmatization;System;Testing;transgender women;United States National Institutes of Health;Unsafe Sex;uptake;verbal;Violence;Viral;Viral Load result;Work

PROJECT_TITLE: Sweekar - Multi-level intersectional stigma reduction to increase HIV testing and care engagement among trans women in Nepal

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Asthma;Attention Deficit Hyperactivity Disorder (ADHD);Brain Disorders;Genetics;Lung;Mental Health;Pediatric

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: PROJECT NARRATIVE Although a rich epidemiological literature has demonstrated a high comorbidity between asthma, the most common respiratory disease worldwide, and attention-deficit/hyperactivity disorder (ADHD), the most common behavioral disorder among children, with reports of significant increases in diagnoses in recent years, no studies have interrogated the potential molecular pathobiology underlying the mutual excess risk between asthma and ADHD. This proposal aims to use integrative techniques by combining genetic and metabolomic data to characterize common and distinct mechanisms and pathways of dysregulated metabolism in the presence of comorbid asthma and ADHD and to develop multiomic profiles which can assist in predicting higher risk of ADHD among asthmatic children. The findings from this study will be instrumental in understanding the molecular underpinnings of two highly prevalent public health concerns, and this study will be the first of its kind to interrogate the molecular intersections between asthma and ADHD.

PI_NAMEs: CHU, SU HEE (contact)

PROGRAM_OFFICER_NAME: LU, JINING

PROJECT_TERMS: Achievement;Adolescence;Adult;antenatal;Area;Asthma;asthmatic;asthmatic patient;Attention deficit hyperactivity disorder;Awareness;Behavior Disorders;Biochemical;Biological;Biological Markers;biological systems;career;career development;Child;Childhood;Childhood Asthma;Clinical;cohort;Communication;Communities;comorbidity;Complex;Data;Diagnosis;Disease;Doctor of Philosophy;Educational process of instructing;Ensure;Environmental Exposure;Epidemiologist;Epidemiology;Etiology;experience;Formulation;Genetic;genetic testing;genetic variant;Genetic Variation;Goals;high risk;Hospitals;improved;inattention;Individual;insight;Joints;Libraries;life span;Link;Literature;Longitudinal Studies;Machine Learning;Mediating;Mediation;Mediator;medical schools;Mentored Research Scientist Development Award;Mentors;Mentorship;Metabolic;Metabolic Pathway;metabolic phenotype;metabolic profile;Metabolism;metabolomics;method development;Methods;Modeling;Molecular;Multiomic Data;multiple omics;Neurodevelopmental Disorder;novel;Pathway interactions;Patients;Phenotype;predictive modeling;Prevalence;Process;Program Development;programs;prospective;Prospective cohort;Prospective Studies;psychogenetics;Public Health;Reporting;Research;research and development;Research Design;Research Personnel;Respiration Disorders;Respiratory Disease;Risk;screening;skills;small molecule;Specific qualifier value;Sphingolipids;Statistical Methods;statistics;success;System;Techniques;Testing;theories;Training;Tryptophan;Validation;Variant;Vitamin D;Woman

PROJECT_TITLE: Integrative metabolomic characterization of ADHD and asthma comorbidity

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(MA)]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Clinical Research;Neurosciences

ORG_CITY: BALTIMORE

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative Hearing and balance disorders affect millions of people worldwide, yet the underlying damage patterns in the ear are not understood well for many inner ear-related clinical problems. This project will develop a large human temporal bone collection as a resource for the scientific community to investigate the inner ear correlates of hearing and balance problems in a diverse population. The project will also refine methods for rapid processing of newly obtained temporal bones and create a multi-platform imaging and analysis pipeline for maximization of the information obtained from each specimen.

PI_NAMEs: CAREY, JOHN PATRICK;LAUER, AMANDA M. (contact)

PROGRAM_OFFICER_NAME: CYR, JANET

PROJECT_TERMS: 2019-nCoV;3-Dimensional;Academic Medical Centers;Acceleration;Address;Adopted;Affect;African American population;Age;Aging;analysis pipeline;Animal Disease Models;Arachnoid mater;Auditory;Autopsy;Baltimore;bilingualism;Biological;Brain;Brain Stem;Catalogs;Childhood;Clinical;Cochlea;Collaborations;Collection;Communication;Communities;Consent;cost;crowdsourcing;Data;Databases;Decalcification;Democracy;demographics;digital;Disease;Ear;Ear Diseases;Education;Education and Outreach;education resources;Educational Materials;Enrollment;Ensure;epidemiology study;equilibration disorder;Equilibrium;Equipment;Facial nerve structure;Faculty;Funding;Goals;Harvest;Health;Hearing;Hearing problem;Hematoxylin and Eosin Staining Method;Histology;Human;Image;imaging platform;Improve Access;Information Dissemination;Infrastructure;inner ear diseases;Intention;Knowledge;Laboratories;Laboratory Finding;Laboratory Research;Labyrinth;Longitudinal Studies;macula;Measures;Medical;Medical Illustration;meetings;Melanins;Meniere's Disease;Mentors;microCT;Modernization;Nature;nerve supply;Neurosciences;nonhuman primate;novel;Online Systems;otoconia;Otology;outreach;Participant;Pathology;Pattern;Persons;Population Heterogeneity;Population Study;Postdoctoral Fellow;pre-doctoral;Presbycusis;preservation;Prevalence;Process;programs;Proliferating;Protocols documentation;rapid technique;reconstruction;Recording of previous events;recruit;Research;Research Personnel;Resources;response;Role;Scientist;Semicircular canal structure;sex;Sickle Cell Anemia;Slide;Specimen;Stains;Students;Techniques;Temporal bone structure;Testing;Time;timeline;Tissues;tool;Training;training opportunity;transcriptomics;Uncertainty;Underrepresented Populations;Underrepresented Students;Vestibular Diseases;Vestibular function;vestibular system;Visualization;Work;working group

PROJECT_TITLE: Johns Hopkins Human Temporal Bone Resource


ORG_CITY: DOVER

ORG_NAME: DELAWARE STATE UNIVERSITY

ORG_STATE: DE

PHR: Interdisciplinary Health Equity Research Center Public Health Relevance Summary Because of the diversity of their faculty and students, and places of trust in the community, HBCUs such as Delaware State University, are strategically poised to make important scientific contributions addressing the serious problem of racial/ethnic health disparities. Support from the RCMI program to establish the Interdisciplinary Health Equity Research Center at DSU will build a capacity for biomedical, behavioral and social research targeting understanding and reducing health disparities. The Center will support early stage investigators to reach the level of research capability competitive for external funding and necessary to pursue discovery science that will translate into improvements in the health status of minority individuals and communities.

PI_NAMEs: GUPTA, SANGEETA ;HARRINGTON, MELISSA A (contact)

PROGRAM_OFFICER_NAME: PATEL, ANURADHA DIPAK

PROJECT_TERMS: Address;African American;Alzheimer's disease diagnostic;Applications Grants;Asian;Awareness;Beds;Behavioral;Behavioral Research;Biological;Biomedical Research;Biometry;burden of illness;career;career development;career networking;Caucasians;Clinical;clinical care;collaborative approach;Collection;Communities;community engagement;community organizations;community partners;contextual factors;Core Facility;COVID-19;COVID-19 pandemic;Data;Delaware;Development;Dissemination and Implementation;Economic Development;Electrophysiology (science);ethnic health disparity;Ethnic Origin;Event;experience;Faculty;falls;Fostering;Funding;Future;Goals;Grant;Health;health care disparity;health determinants;Health Disparities Research;health disparity;health equity;health equity promotion;Health equity research;Health Status;Hispanic;Historically Black Colleges and Universities;Human Resources;human subject;improved;Infrastructure;innovation;Institution;Institutional Review Boards;interdisciplinary collaboration;Interdisciplinary Study;Intervention;Lead;Link;literacy;Low income;meetings;member;Mentors;Mentorship;Microscopy;mid-career faculty;minority communities;Minority Groups;molecular diagnostics;Native Americans;Neighborhoods;next generation;Nursing Research;Outcome;outcome disparities;Outcomes Research;Patient Education;Patient-Focused Outcomes;Pilot Projects;Population;Positioning Attribute;Process;programs;public health relevance;Qualitative Methods;Qualitative Research;Race;racial diversity;racial health disparity;racial population;RADx Underserved Populations;Recording of previous events;recruit;Reduce health disparities;Reporting;Research;research and development;Research Personnel;Research Project Grants;Resources;Rural;SARS-CoV-2 infection;Science;Scientist;Scourge;Secure;social;social health determinants;Socioeconomic Status;Structure;Students;Targeted Research;Testing;Training;Translating;Translational Research;Trust;Underrepresented Minority;Underrepresented Populations;underserved community;Underserved Population;United States;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Interdisciplinary Health Equity Research (IHER) Center


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: HARRINGTON, MELISSA A (contact)

PROJECT_TERMS: Address;Advisory Committees;Applications Grants;Award;Basic Science;Behavioral;Behavioral Research;Biomedical Research;career;Center for Translational Science Activities;Clinical;clinical development;Clinical Research;Collaborations;Communities;community engagement;community organizations;Community Outreach;Data;Delaware;Development;Discipline;Discipline of Nursing;Effectiveness;Ensure;Epidemiologist;Epidemiology;Evaluation;experience;Faculty;Feedback;formative assessment;Funding;Goals;graduate student;Grant;Health;Health behavior;health determinants;Health Disparities Research;health disparity;health equity;Health equity research;health science research support;Health Status;Human Resources;IACUC;improved;Infrastructure;innovation;insight;Institution;Institutional Review Boards;Interdisciplinary Study;Leadership;Link;Measures;meetings;member;Mentors;Minority;minority health;Minority Health Research;Modeling;molecular diagnostics;Morbidity - disease rate;mortality;National Institute on Minority Health and Health Disparities;next generation;novel;operation;Outcome;outcome disparities;Outcomes Research;Patient-Focused Outcomes;Positioning Attribute;Postdoctoral Fellow;Process;Productivity;programs;Public Health;racial minority;Reduce health disparities;Regulation;Reporting;Research;Research Personnel;Research Project Grants;Research Support;Resources;Role;Scientist;social;Structure;student training;Students;success;summer research;Training;Training Support;Translational Research;undergraduate student;Underrepresented Populations;Underserved Population;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Brain Disorders;Clinical Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Prevention

ORG_CITY: NASHVILLE

ORG_STATE: TN

PHR: Project Narrative It has been proposed that differences in sensory responsiveness may emerge early in life from altered brain states and impact a child's ability to engage with their environment, thereby producing cascading effects on language acquisition in children affected by autism. The Sensory Project in Infant/Toddler Siblings of Children with Autism (Project SPIS) represents a comprehensive test of this “cascading effects” framework in infants at increased familial likelihood for a future diagnosis of autism and language disorder and infants at relatively lower, general population-level likelihood of these conditions. This innovative and interdisciplinary line of research is expected to facilitate earlier identification of language impairments and point towards novel targets of “preventative” interventions, thereby improving the long-term outcomes of children with, or at elevated likelihood of, autism and language disorder.

PI_NAMEs: WOYNAROSKI, TIFFANY  (contact)

PROGRAM_OFFICER_NAME: STORKEL, HOLLY LYNN

PROJECT_TERMS: 5 year old;Affect;Age;Age Months;Autism Diagnosis;autism spectrum disorder;autistic children;Behavioral Mechanisms;Brain;Caregivers;Child;Clinical;Clinical Trials;Communication;Development;Diagnosis;Diagnostic;Distal;Early identification;efficacy evaluation;efficacy testing;Environment;Equipment and supply inventories;experience;Foundations;Funding;Future;General Population;Growth;improved;individuals with autism spectrum disorder;infancy;Infant;innovation;Intervention;Intuition;joint attention;Language;Language Development;Language Disorders;language impairment;language outcome;Life;Linguistics;Link;Measures;Mediating;mental age;National Institute on Deafness and Other Communication Disorders;Nature;neuromechanism;novel;Outcome;Population;Predictive Value;preventive intervention;prospective;Research;Rest;Risk;scale up;Sensory;sex;Siblings;skills;social;Speech;Subgroup;success;targeted treatment;Testing;theories;Toddler;Translating;Vocation;Work

STUDY_SECTION: LCOM

STUDY_SECTION_NAME: Language and Communication Study Section[LCOM]