NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: LA JOLLA

ORG_NAME: SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

PHR: PROJECT NARRATIVE APOE4 is the greatest known genetic risk factor for sporadic Alzheimer's and there exists a high unmet medical need for therapeutics that could prevent disease associated with this variant. We have developed an innovative split luciferase assay that can detect the binding of compounds to ApoE4 in cells. We propose to leverage this breakthrough to both discover new and optimize known ApoE4 correctors into drugs that can generate in vivo proof of concept that they can functionally correct ApoE4 pathobiology in murine models and ultimately be developed into a therapeutic for AD.

PI_NAMEs: HYMAN, BRADLEY T.;JACKSON, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: GROTHAUS, PAUL G

PROJECT_TERMS: Alleles;Alzheimer's Disease;Alzheimer's disease risk;Alzheimer's disease therapeutic;Amino Acids;Amyloid deposition;analog;Apolipoprotein E;apolipoprotein E-3;apolipoprotein E-4;Arginine;Astrocytes;Automobile Driving;Binding;Binding Sites;Biological;Biological Assay;Biological Markers;Biology;biophysical analysis;Blood - brain barrier anatomy;blood-brain barrier crossing;blood-brain barrier function;blood-brain barrier penetration;Brain;C-terminal;Cell model;Cells;Chemistry;Clinical Trials;Complex;Cysteine;Data;Defect;design;Development;Disease;DNA Sequence Alteration;Docking;Dose;Drug Kinetics;effective therapy;Emerging Technologies;Engineering;experimental study;Functional disorder;gain of function;Genetic;Genetic Risk;genetic risk factor;Genotype;high throughput screening;Human;human induced pluripotent stem cells;improved;in silico;In Vitro;in vivo;Individual;induced pluripotent stem cell;Inherited;innovation;insight;Laboratories;Lead;Length;Libraries;Lipid Binding;Lipids;loss of function;Luciferases;Mediating;Medical;melting;Membrane;Modeling;Molecular Conformation;mouse model;Mus;Mutate;Mutation;N-terminal;nanoluciferase;Neurofibrillary Tangles;novel;Pathway interactions;Patients;Pharmaceutical Chemistry;Pharmaceutical Preparations;Pharmacodynamics;Phenotype;Positioning Attribute;prevent;Property;Protein Conformation;Protein Isoforms;Proteins;Public Health;Publishing;Recombinants;Relative Risks;response;Risk;Route;scaffold;Scientist;small molecule;Structure;Synapses;Temperature;Testing;Therapeutic;Tissues;Toxic effect;Transfection;Transgenic Animals;Transgenic Mice;Transgenic Model;Transgenic Organisms;Variant

PROJECT_TITLE: Discovery and development of apoE4 correctors for the treatment of Alzheimer's disease

STUDY_SECTION: DMPB

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology B Study Section[DMPB]


ADMINISTERING_IC: HL

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Bioengineering;Biotechnology;Brain Disorders;Cerebrovascular;Dementia;Disability Research;Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: LIVERMORE

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: LAWRENCE LIVERMORE NATIONAL SECURITY, LLC

ORG_STATE: CA

PHR: PROJECT NARRATIVE Lasting impacts: dynamic, fully natural bioprinted 3d human neurovascular biomimetic to study traumatic  brain injury pathophysiology Traumatic brain injury (TBI) is a significant concern for military personnel and global public health, as patients who experience TBI often develop memory and behavioral impairments and are at heightened risk for developing neurodegenerative diseases later in life. The lack of adequate in vitro models that capture the complexity of neurovascular coupling is a key challenge to understanding mechanism and possible therapeutic approaches to improve the effects of TBI on cerebral vasculature. This research focuses on developing a biofidelic neurovascular unit to test the hypothesis that biomechanics of TBI (i.e., shear from trauma of the primary injury and variations in cerebral “blood flow”—a secondary injury of TBI) spatially and temporally influence vascular and neural pathology.

PI_NAMEs: GOLDSTEIN, LEE E.;MOYA, MONICA LIZET (contact)

PROGRAM_OFFICER_NAME: LUNDBERG, MARTHA

PROJECT_TERMS: 3-Dimensional;3D Print;Acute;Address;Affect;Alzheimer's Disease;Animal Experiments;Animals;Astrocytes;behavioral impairment;biofabrication;Biological Assay;Biological Models;biomaterial compatibility;Biomechanics;Biomimetics;biophysical properties;bioprinting;Blood;Blood - brain barrier anatomy;Blood brain barrier dysfunction;Blood Coagulation Disorders;Blood Vessels;blood-brain barrier disruption;Boston;Brain;Brain Injuries;Brain Pathology;Cell Maturation;cell type;Cerebrovascular Circulation;Cerebrovascular system;Chronic;chronic traumatic encephalopathy;Coagulation Process;Cognitive deficits;Collaborations;Companions;Computer Simulation;Defect;dementia risk;disability;Economics;Endothelium;Engineering;experience;fluid flow;Functional disorder;Funding;Goals;Human;human induced pluripotent stem cells;Impairment;implantation;improved;in silico;In Situ;In Vitro;in vitro Model;in vivo;Incubated;indexing;Individual;induced pluripotent stem cell;Injury;innovation;instrument;instrumentation;interest;interstitial;Investigation;Laboratories;Life;Link;Liquid substance;Location;Long term disability;Maps;Measurement;Mechanics;medical schools;Membrane;Memory impairment;Microscopic;Microvascular Dysfunction;Military Personnel;Modeling;Molecular;molecular pathology;Morbidity - disease rate;mortality;multidisciplinary;Nerve Degeneration;Nervous System Trauma;neural;Neurodegenerative Disorders;Neurons;neuropathology;neuropsychiatry;neurovascular;neurovascular coupling;neurovascular unit;Optics;Outcome;Pathology;Patients;Percussion;Pericytes;Permeability;Persons;Phase;Phenotype;Physiological;Plasma;Preparation;programs;Property;psychosocial;Public Health;Research;response;response to brain injury;response to injury;Risk;Role;Severities;shear stress;simulation;Site;Slice;spatiotemporal;Specimen;Structure;Survivors;tau Proteins;tau-1;Tauopathies;Testing;Therapeutic;Time;Tissues;Trauma;Traumatic Brain Injury;United States National Institutes of Health;Universities;Variant;vascular contributions;Vascular Diseases;vascular injury;Visualization;Work

PROJECT_TITLE: Lasting Impacts: Dynamic, Fully Natural Bioprinted 3D Human Neurovascular Biomimetic Model to Study Traumatic Brain Injury Pathophysiology


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF EDUCATION

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Suicide;Suicide Prevention

ORG_CITY: EUGENE

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF OREGON

ORG_STATE: OR

PHR: Narrative Adolescence is a developmental period of significant risk for anxiety, depressive symptoms, and suicidality, and we propose to target key peer-based risk and protective factors using Cooperative Learning (CL). CL is a small-group instructional approach that can enhance peer relations and reduce peer-related risks, as well as promote academic engagement and achievement and reduce racial disparities. CL will be delivered with the aid of technology that automates the design and delivery of CL lessons, promoting rapid implementation, scalability, high fidelity, accessibility, and sustainability.

PI_NAMEs: VAN RYZIN, MARK J (contact)

PROGRAM_OFFICER_NAME: ROONEY, MARY

PROJECT_TERMS: Academic support;access disparities;Achievement;Active Learning;Address;Adolescence;Adolescent;adolescent mental health;Anxiety;anxious;Award;black men;bullying;Cognitive Therapy;Computer software;coronavirus pandemic;cost;cost effectiveness;COVID-19 pandemic;Data;Depressed mood;depressive symptoms;design;Development;Disadvantaged;Discrimination;Disparity;dosage;Education;Emotional;Ensure;Equity;ethnic disparity;Ethnic Origin;experience;Feeling;Feeling hopeless;Feeling suicidal;Female;Friendships;Fright;Geography;Healthcare;help-seeking behavior;Heterogeneity;high school;High School Student;Hispanic;implementation fidelity;innovation;insight;Instruction;interest;intervention effect;Latina Population;Link;Loneliness;Mental Depression;Meta-Analysis;Minority Groups;Minority Men;Monitor;Outcome;pandemic disease;peer;Performance;Population;prevent;Prevention approach;Prevention program;prevention service;Prevention strategy;Primary Prevention;Problem behavior;programs;protective factors;Public Health;Race;racial disparity;Racial Equity;randomized trial;Recommendation;Reporting;Research;Risk;Risk Factors;risk minimization;Rural;scale up;Schools;Services;Social isolation;Stigmatization;Stress;Students;substance use;suicidal;Suicide;Suicide attempt;Suicide prevention;Surveys;Symptoms;teacher;Teaching Method;Technology;Testing;Time;Training;trend;universal prevention;uptake;validation studies;Victimization;web based software;willingness;Youth

PROJECT_TITLE: Transforming adolescent mental health through accessible, scalable, technology-supported small-group instruction

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-J(70)R]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Comparative Effectiveness Research;Dental, Oral, and Craniofacial Disease;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: NASHVILLE

ORG_DEPT: DENTISTRY

ORG_NAME: MEHARRY MEDICAL COLLEGE

ORG_STATE: TN

PHR: Meharry Medical College (MMC) is a historically black college that routinely oversees the healthcare needs of underserved populations and patients with low socioeconomic status affected by multiple medical and dental comorbidities. Enhancing clinical research skills at MMC, School of Dentistry may enhance the interest of minority dental-physician scientists in engaging with academia in research across the USA.

PI_NAMEs: GANGULA, PANDU R (contact)

PROGRAM_OFFICER_NAME: BACCAGLINI, LORENA

PROJECT_TERMS: Academia;Academic Medical Centers;Acquired Immunodeficiency Syndrome;Affect;African American;Automobile Driving;Biological;biomarker identification;Black American;Caring;Case Study;Clinic;Clinical;Clinical and Translational Science Awards;clinical investigation;Clinical Research;clinical training;Collaborations;Communities;comorbidity;Computational Science;Critical Thinking;Dental;Dental Faculty;Dentists;design;Disease;disorder risk;education research;Educational Curriculum;Evaluation;evidence base;experience;Faculty;Feedback;Genomics;Goals;Healthcare;high risk;Historically Black Colleges and Universities;HIV;HIV Seronegativity;HIV Seropositivity;Immersion;Immune mediated destruction;Immunologics;improved;Incidence;Inflammation;Inflammatory;Institution;inter-institutional;interest;Journals;Knowledge acquisition;Learning;Letters;Literature;low socioeconomic status;Mediating;Medical;medical schools;metabolomics;Minority;Minority Groups;minority trainee;Modeling;multidisciplinary;Oral;Oral health;Outcome;pathogenic microbe;patient population;Patients;peer coaching;Peer Review;Periodontal Diseases;Periodontium;Persons;Physicians;Population;Positioning Attribute;Postdoctoral Fellow;Practice based research;pre-doctoral;Process;programs;Prosthodontic specialty;Proteomics;Public Health;Publishing;recruit;Research;Research Infrastructure;Research Personnel;Research Training;Resources;Rotation;Rural Community;Saliva;School Dentistry;Scientist;Severities;Signal Pathway;skill acquisition;skills;socioeconomics;Specimen;Structure;student mentoring;Students;Surveys;symposium;Training;Training Programs;transcriptomics;Underinsured;Underrepresented Minority;underserved area;underserved community;Underserved Population;Uninsured;United States;vulnerable community;Wellness Center

PROJECT_TITLE: Multidisciplinary Practice-Based Research Training in Meharry Medical College, School of Dentistry


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: DETROIT

ORG_DEPT: PHYSIOLOGY

ORG_NAME: WAYNE STATE UNIVERSITY

ORG_STATE: MI

PHR: The goal of this proposal is to develop and evaluate an “in-line and just in time” filtration platform composed of ß-cyclodextrin-based adsorbents, beads and micro/ultra-filtration membranes, that will preserve tissue integrity, and mitigate dermal pathologies associated with subcutaneous insulin administration (SIA)-devices by removing tissue cytotoxic and pro-inflammatory insulin phenolic preservatives and insulin derived fibrils present in commercial insulin formulations. This filtration platform can be easily integrated into current drug delivery devices without the need for the preparation of new insulin formulations, which will save time, money, and effort to advance the development of more effective and specific SIA-devices that will optimize future diabetes therapies.

PI_NAMEs: KLUEH, ULRIKE  (contact);SHARAFIEH, ROSHANAK

PROGRAM_OFFICER_NAME: ARREAZA-RUBIN, GUILLERMO

PROJECT_TERMS: absorption;Achievement;Acute;Advanced Development;Air;Architecture;beta-Cyclodextrins;Binding;Binding Sites;Biological;Blood Glucose;blood glucose regulation;Cell Line;Cell-Mediated Cytolysis;Cells;Characteristics;Chemicals;Chronic;clinically relevant;Continuous Glucose Monitor;Cresol;Cyclodextrins;cytotoxic;cytotoxicity;cytotoxicity test;Data;Dermal;design;Devices;diabetes management;diabetes mellitus therapy;Dose;drinking water;Drug Delivery Systems;euglycemia;Excision;extend lifespan;Failure;Family suidae;Fibrosis;Filtration;Food Processing;Formulation;Future;Glucose;Goals;Human;Hydrophobicity;In Vitro;in vivo;Inflammation;Inflammatory;Inflammatory Response;Infusion procedures;Infusion Pumps;Injections;Insulin;Insulin Infusion Systems;Insulin-Dependent Diabetes Mellitus;Legal patent;Life;Literature;Location;Macrophage;manufacture;Mechanics;Membrane;Molecular Conformation;mouse model;Mus;novel;Pathology;Pharmaceutical Solutions;pharmacokinetics and pharmacodynamics;Phenols;Physiological;Plant Resins;polymerization;Polymers;porcine model;Practice Management;pre-clinical;Predisposition;Preparation;preservation;pressure;Proteins;Publishing;Reaction;Recommendation;Recurrence;Reporting;Rotation;sensor;Serum;Site;Skin;Solvents;Sterility;stressor;Structure;subcutaneous;Subcutaneous Tissue;System;Technology;Testing;Time;Tissue Preservation;Tissues;Toxic effect;Ultrafiltration;wasting;water treatment;wound healing;Zeolites

PROJECT_TITLE: A novel inline platform provides an advanced drug delivery device foroptimized diabetes therapy

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]


ADMINISTERING_IC: HD

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Contraception/Reproduction;Infertility

ORG_CITY: CHAMPAIGN

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

ORG_STATE: IL

PHR: Project Narrative After semen deposition, sperm form a reservoir in the oviduct, which supplies sperm to the site of fertilization. Research in this proposal will study sperm binding to the oviduct wall, how binding to the wall increases sperm lifespan, and determine if this fundamental research may be translated to improve the health of offspring produced by a modified in vitro fertilization technique. This fundamental knowledge may lead to simpler, more effective, and less expensive methods to improve the fertility and health of offspring from humans and many species.

PI_NAMEs: MILLER, DAVID JOEL (contact)

PROGRAM_OFFICER_NAME: KENT, TRAVIS JOHN

PROJECT_TERMS: Abnormal placentation;Adhesions;Affect;Affinity;Affinity Chromatography;Assisted Reproductive Technology;Binding;CatSper;Cells;Characteristics;Cholesterol;Citric Acid Cycle;Coenzyme A;Complex;cost;CpG Islands;CRISPR/Cas technology;cytotoxic;Deposition;Development;differential expression;diminished oxidative phosphorylation;Electron Transport;Embryo;Embryonic Development;Epithelial Cells;Family suidae;Fertility;fertility improvement;Fertilization;Fertilization in Vitro;Frequencies;Fumarates;fundamental research;Funding;Genes;Genetic;Germ Cells;Glycocalyx;Goals;Health;Human;Immobilization;improved;In Vitro;in vivo;Infertility;Insemination;insight;Intracytoplasmic Sperm Injections;Knowledge;Lead;life span;Low Birth Weight Infant;Mammalian Oviducts;Membrane;Metabolic;Metabolism;Methods;methylome;methylomics;Microscope;Modeling;Molecular;Motility;Mus;Mutate;Mutation;offspring;Oocytes;Ovary;Oxidative Phosphorylation;Phosphotransferases;Polysaccharides;Premature Birth;Process;Production;Progesterone;promoter;Proteins;Reactive Oxygen Species;receptor;Research;response;Risk;Seminal fluid;sialylation;Signal Transduction;Site;Slide;sperm cell;Sperm Count Procedure;sperm viability;Sperm-Ovum Interactions;stillbirth;success;Sulfate;System;Techniques;Tissues;tool;transcriptome;transcriptomics;Translating;Trisaccharides;Ubiquinone;Ubiquitin;Uterus

PROJECT_TITLE: Accumulation, Storage, and Release of Sperm in the Oviduct

STUDY_SECTION: CMIR

STUDY_SECTION_NAME: Cellular, Molecular and Integrative Reproduction Study Section[CMIR]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Adolescent Sexual Activity;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Pediatric;Prevention

ORG_CITY: GOLDEN

ORG_NAME: KLEIN BUENDEL, INC.

ORG_STATE: CO

PHR: PROJECT NARRATIVE The proposed research will fill a gap by completing the adaptation of iTRAC, a web-based emotion regulation sexual health intervention, and testing its efficacy in promoting safer sexual cognitions and delaying sexual initiation among early adolescents. This application addresses the Office of Disease Prevention and Health Promotion's Healthy People 2030 indicator FP-08, to increase the proportion of adolescents who get formal sex education before age 18 years (currently less than 53%). It also uses a novel approach, emotion regulation skills training, to address indicator FP-04, to increase the proportion of adolescents who have never had sexual intercourse, and indicator FP-06, to increase the proportion of adolescents who used condoms at last sexual intercourse.

PI_NAMEs: HOUCK, CHRISTOPHER D. (contact)

PROGRAM_OFFICER_NAME: POPKIN, RONNA

PROJECT_TERMS: 18 year old;academic standard;acceptability and feasibility;Address;Adolescence;Adolescent;adolescent health;Adolescent Risk Behavior;adolescent sexual health;Affect;after-school program;Age;Assertiveness;Attention;Awareness;behavior change;Behavioral;Biological;Cognition;Coitus;Collaborations;community advisory board;community partners;comparison group;Competence;condoms;critical developmental period;Data;Decision Making;design;Development;digital;digital intervention;disorder prevention;distress tolerance;early adolescence;Education;Educational process of instructing;efficacious intervention;efficacy evaluation;emotion regulation;Emotional;emotional factor;Emotions;Exhibits;Feedback;Female;Female Adolescents;follow-up;Future;group intervention;Health;Health behavior change;health communication;Health education;health knowledge;Health Professional;Health Promotion;high risk behavior;HIV;Hospitals;improved;innovation;Internet;Intervention;Interview;Link;male;Male Adolescents;Marketing;Measures;Mediating;Methods;novel;novel strategies;online delivery;Online Systems;Outcome;Parents;Participant;Patient Self-Report;Pattern;Performance;Persons;Phase;Pilot Projects;prevent;Prevention;preventive intervention;Professional Education;programs;prototype;Puberty;Public Health;Randomized;randomized trial;Randomized, Controlled Trials;Recording of previous events;Reporting;Research;Rhode Island;Risk;school health;Schools;Self Efficacy;sex;Sex Behavior;Sex Education;Sexual Health;sexual health intervention;sexual initiation delay;sexual risk taking;Sexually Transmitted Diseases;skills;skills training;Small Business Technology Transfer Research;social;System;Tablets;technological innovation;Technology;Teenagers;tenth grade;Testing;Time;Training;Translating;Translations;unintended pregnancy;uptake;Waiting Lists;web-based intervention;Work;Youth

PROJECT_TITLE: An Interactive Education Program to Reduce High Risk Behavior in Adolescents

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-RPHB-D(16)]


ADMINISTERING_IC: NR

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Adolescent Sexual Activity;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Pediatric;Prevention;Sexually Transmitted Infections;Social Determinants of Health;Teenage Pregnancy;Women's Health Research

ORG_CITY: SAN CLEMENTE

ORG_NAME: CENTER FOR INNOVATIVE PUBLIC HEALTH RESEARCH

PHR: Youth who are assigned female at birth (AFAB) and identify as transgender (e.g., as non-binary or as trans boys), not as girls, are at risk for negative sexual health outcomes yet are effectively excluded from sexual health programs because gender-diverse youth do not experience the cisgender, heteronormative teen sexual education messaging available to them as salient or applicable. This lack of programming is likely contributing to obstacles to sexual health: Data suggest that AFAB trans-identified youth may be less likely to use condoms when having sex with people who have penises and are at least as likely as cisgender girls to be pregnant. #TranscendentHealth aims to address this health inequity.

PI_NAMEs: YBARRA, MICHELE L. (contact)

PROGRAM_OFFICER_NAME: WILLIS, LEIGH ANDREW

PROJECT_TERMS: 18 year old;abortion;Address;Adolescence;Adolescent;adolescent health;Adult;Advisory Committees;Affect;Age;Alabama;assigned female at birth;Behavior;birth control;boys;Caring;cisgender;cohort;condoms;Data;Decision Making;design;Discrimination;dysphoria;Education;Equity;Exclusion;experience;Feedback;Focus Groups;Foundations;Gender;gender affirming care;gender diverse;girls;healing;Health;Health education;health equity;health inequalities;Health Promotion;Health Resources;Health Services;Health Status;HIV;HIV/STD;Laws;lens;Lesbian Gay Bisexual;Lesbian Gay Bisexual Transgender;Los Angeles;Measures;Methods;National Institute of Nursing Research;nonbinary;Nursing Research;Outcome;Outcome Measure;penis;Persons;post intervention;pre-exposure prophylaxis;Pregnancy;Pregnancy in Adolescence;Pregnancy Rate;pregnant;pressure;Prevalence;Prevention;Prevention program;Preventive;Process;programs;Protocols documentation;Public Health;recruit;Research;Research Personnel;Resources;Risk;Rural;Safe Sex;scale up;secondary outcome;sex;Sex Behavior;Sexual Health;sexual minority girls;Signal Transduction;social;social media;social stressor;Statutes and Laws;suburb;Supreme Court Decisions;Surveys;Technology;Teenagers;Test Result;Testing;Text Messaging;transgender;transsexual;Update;uptake;urban setting;Vagina;Woman;Work;Youth

PROJECT_TITLE: #TranscendentHealth - Adapting an LGB+ inclusive teen pregnancy prevention program for transgender boys

STUDY_SECTION: SPIP

STUDY_SECTION_NAME: Social Psychology, Personality and Interpersonal Processes Study Section[SPIP]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Comparative Effectiveness Research;Dental, Oral, and Craniofacial Disease;Infectious Diseases;Machine Learning and Artificial Intelligence;Microbiome;Networking and Information Technology R&D (NITRD);Prevention

ORG_CITY: PHILADELPHIA

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

ORG_STATE: PA

PHR: PROJECT NARRATIVE Prediction models to assess periodontal disease (PD) risk have been developed. However, their clinical use is rare because of their suboptimal performance and absence of oral microbiome data, social determinants and behavioral factors, and accurate medical history. This application seeks to use real-time medical data from a health share exchange to develop a continuity of care report for oral health care, to build a risk prediction models for PD using machine learning approaches including subgingival and salivary microbiome data and to identify potential high resolution biomarkers of PD progression for better disease control and prevention.

PI_NAMEs: TELLEZ MERCHAN, MARISOL  (contact)

PROGRAM_OFFICER_NAME: GRISIUS, MARGARET

PROJECT_TERMS: 16S ribosomal RNA sequencing;Address;Adult;Affect;American;Applications Grants;Artificial Intelligence;Assessment tool;Behavioral;Biological Markers;Biometry;Caring;certificate program;Classification;Clinical;Clinical Decision Support Systems;clinical practice;Clinical Research;Cohort Studies;Collaborations;college;Consent;Continuity of Patient Care;Coupled;Data;Data Analyses;Data Set;Decision Making;Dental;Dental Education;Dental Epidemiology;Dental General Practice;Dental Schools;Dental Students;Dentists;Development;diagnostic accuracy;disability;Disease;disease diagnosis;disease model;Disease Progression;disorder control;disorder prevention;disorder risk;dysbiosis;Early Diagnosis;Electronic Health Record;empowerment;Faculty;Funding;Genes;Goals;Grant;Health;Health Status;Healthcare;improved;Incidence;indexing;Individual;innovation;Knowledge;Laboratories;Learning;Machine Learning;Medical;Medical History;Medical Records;medical schools;meetings;metagenomic sequencing;Metagenomics;microbial;microbial signature;microbiome;microbiome analysis;Modeling;multiple data sources;Nested Case-Control Study;novel;novel strategies;Nursing Faculty;Oral;Oral health;oral microbiome;Pain;Pathway interactions;patient oriented research;Patient Self-Report;Patients;Pennsylvania;Performance;Periodontal Diseases;Periodontitis;Physicians;Population;Postdoctoral Fellow;potential biomarker;Practice based research;practice-based research network;pre-doctoral;predictive marker;predictive modeling;Prevention;programs;Prospective, cohort study;psychologic;Public Health;Public Health Informatics;Quality of life;Records;recruit;Reporting;Research;Research Activity;Research Project Grants;research study;Research Support;Resolution;response;Risk Assessment;Risk Factors;risk prediction model;Saliva;saliva sample;Salivary;Sampling;School Dentistry;Schools;Science;Shotguns;skills;social determinants;Statistical Models;student mentoring;student training;Students;subgingival microbiome;Teacher Professional Development;Testing;Time;tool;Tooth Loss;Training;Universities

PROJECT_TITLE: Sequential Modeling for Prediction of Periodontal Diseases: an intra-Collaborative Practice-based Research study (ICPRS)


NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Infectious Diseases

ORG_CITY: BOSTON

ORG_NAME: HARVARD MEDICAL SCHOOL

ORG_STATE: MA

PHR: Periodontitis is a common human mucosal chronic inflammatory disease characterized by destruction of tooth supporting structures, where severe and debilitating periodontitis affects 8-10% of the U.S. population. While it is well appreciated that host-susceptibility is a controlling factor of periodontitis development, a key knowledge gap is the identification of molecular determinants of host susceptibility that mediate severe periodontal disease. The goal of this research proposal is to understand how local fibrin-neutrophil engagement, a novel molecular determinant of periodontitis, mediates periodontitis pathogenesis in the context of both normal and compromised fibrinolysis.

PI_NAMEs: SILVA, MUNASINGHAGE LAKMALI (contact)

PROGRAM_OFFICER_NAME: CHANDER, PREETHI

PROJECT_TERMS: Adolescence;Advisory Committees;Affect;alveolar bone;Alveolar Bone Loss;Animal Model;Area;Binding;Biological Assay;Biology;Blood coagulation;Blood Vessels;bone;bone loss;career;Cells;chronic inflammatory disease;Circulation;Communication;Computers;Data;Dentition;Deposition;Development;Disease;Educational workshop;Environment;Enzyme Precursors;Enzymes;Equipment;extracellular;Fibrin;Fibrinogen;Fibrinolysis;Foundations;Genes;Genetic;Gingiva;Goals;Grant;Growth;Heterozygote;Homeostasis;Human;Image Analysis;Immunity;Immunology;immunopathology;improved;In Vitro;in vivo;Inflammation;Inflammatory;Integrins;Intercellular Fluid;Knowledge;Laboratories;Lead;Leadership;Lesion;Leukocytes;Life;Link;live cell imaging;Liver;Mediating;Mendelian disorder;Mentors;Molecular;Mouth Diseases;Mucosal Immune Responses;Mucosal Immunity;mucosal site;Mucositis;Mucous Membrane;Mus;Mutation;National Institute of Dental and Craniofacial Research;neutrophil;Neutrophil Infiltration;novel;Oral health;Oral mucous membrane structure;oral tissue;Pathogenesis;Pathway interactions;Patients;Peptide Hydrolases;Periodontal Diseases;Periodontitis;Periodontium;pharmacologic;Phase;Physiological;Plasmin;Plasminogen;PLG gene;Population;Predisposition;prevent;Production;Publications;receptor;Regulation;Research;Research Personnel;Research Proposals;Research Training;Role;Signal Transduction;skills;Small Interfering RNA;soft tissue;Teenagers;Testing;Therapeutic;Tissues;Training;Training Activity;Treatment Efficacy;United States National Institutes of Health;Writing

PROJECT_TITLE: Fibrin-neutrophil interaction in periodontitis immunopathology

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Emerging Infectious Diseases;Genetics;HIV/AIDS;Infectious Diseases;Nanotechnology;Orphan Drug;Rare Diseases;Tuberculosis

PHR: Project Narrative: Successful treatment of tuberculosis infections requires the prompt and accurate diagnosis of resistance to the full panel of antibiotics in clinical use. Here we propose a novel approach to diagnose antibiotic resistance to bedaquiline, pretomanid, linezolid, pyrazinamide, and moxifloxacin using RNA hybridization detecting a transcriptomic signature of antibiotic response. This approach circumvents the delays and biohazard of bacterial growth-based tests and the difficulties in interpretation of DNA based methods.

PI_NAMEs: FARHAT, MAHA  (contact)

PROGRAM_OFFICER_NAME: ESPY, NICOLE JOY

PROJECT_TERMS: accurate diagnosis;accurate diagnostics;Address;Antibiotic Resistance;Antibiotic susceptibility;Antibiotics;Antitubercular Agents;Antitubercular Antibiotics;Archives;bactericide;Benchmarking;biobank;Biohazardous Substance;Bioinformatics;Biological Assay;Cells;Cellular Stress;Ciprofloxacin;Clinic;Clinical;cost;Country;COVID-19 diagnosis;Culture Media;Data;design;Detection;detection limit;Development;Diagnosis;Diagnostic;Diagnostic Sensitivity;Diagnostic Specificity;diagnostic strategy;Diagnostic tests;DNA;Dose;Drug Exposure;drug mechanism;Drug resistance;Evaluation;Evolution;Experimental Designs;Exposure to;fluoroquinolone resistance;Fluoroquinolones;Foundations;Genes;Genetic;genetic resistance;Genetic Transcription;Genome;genome sequencing;Geography;Growth;Heat-Shock Response;Hospitals;Hour;In Vitro;Incubated;innovation;isoniazid;Knowledge;Linezolid;Measurement;Messenger RNA;Methods;Molecular Biology;Monitor;Moxifloxacin;Multidrug-Resistant Tuberculosis;Mutation;mycobacterial;Mycobacterium tuberculosis;nano-string;nanosensors;Newly Diagnosed;novel;novel strategies;Participant;pathogen;Patients;Performance;Pharmaceutical Preparations;Phase;Phenotype;point of care;Positioning Attribute;predictive signature;Predisposition;pressure;prospective;prototype;Public Health;Publishing;Pyrazinamide;Rapid diagnostics;rapid test;recruit;Regimen;Research;Resistance;resistance mechanism;resistance mutation;Resistance profile;response;Ribosomal RNA;Rifampicin resistance;Rifampin;Risk;RNA;RNA Probes;Sampling;Sensitivity and Specificity;Signal Transduction;Site;South Africa;South African;Specimen;Sputum;Streptomycin;success;targeted sequencing;Technology;Testing;Time;Transcript;transcriptome sequencing;transcriptomics;Treatment outcome;Tuberculosis;tuberculosis drugs;tuberculosis treatment;Untranslated RNA;whole genome;Work

PROJECT_TITLE: An RNA Nanosensor for the Diagnosis of Antibiotic Resistance in M. Tuberculosis


ADMINISTERING_IC: EB

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_CITY: ITHACA

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: CORNELL UNIVERSITY

ORG_STATE: NY

PHR: Point of Care Technologies for Nutrition, Infection and Cancer for Global Health (PORTENT)  1.0 Overall Narrative Focusing on the largest clinical needs where access to better diagnostics can have the largest worldwide impact, we propose the formation of PORTENT – “Point-of-Care Technologies for Nutrition, Infection and Cancer for Global Health” centered at Cornell University in partnership with Columbia and McGill Universities. At full capacity we will advance between 6 and 7 parallel PoC technology teams through: human validation at one of our network of clinical sites spread across four continents, user and developer training and rotations, and commercialization. The PORTENT Center is differentiable from others as it (1) focuses on primary health care globally; (2) addresses the needs of the most vulnerable in the US and internationally; and (3) enable a broad range of diagnostic technologies to be validated on a global scale while simultaneously developing expertise and building capacity internationally to have the most impact.

PI_NAMEs: ERICKSON, DAVID CARL (contact);MEHTA, SAURABH

PROGRAM_OFFICER_NAME: LASH, TIFFANI BAILEY

PROJECT_TERMS: Address;Africa;Anemia;Area;Asia;Biological Sciences;Businesses;Capital;Cervical Cancer Screening;Clinical;clinical research site;college;commercialization;Communicable Diseases;Consensus;COVID-19 pandemic;Development;Device or Instrument Development;Devices;Diagnostic;diagnostic technologies;Diagnostic tests;Direct Costs;Disparate;early screening;Ecology;Ecuador;Educational workshop;Elements;Engineering;Entrepreneurship;Event;experience;Funding;Generations;global health;health care disparity;Health Personnel;Healthcare Systems;HIV;Human;Incubators;India;Industrialization;Infection;Infrastructure;Institution;interest;International;Iron;Knowledge;Leadership;Letters;low and middle-income countries;Low income;Malaria;Malignant Neoplasms;marginalization;marginalized population;Marketing;Mind;Modeling;multiplex detection;Needs Assessment;Network-based;New York City;next generation;Nongovernmental Organizations;North America;nutrition;Patients;Persons;point of care;Point of Care Technology;point-of-care diagnostics;Population;Population Heterogeneity;Positioning Attribute;Primary Care;Primary Health Care;programs;Qualifying;Regulatory Affairs;Reporting;research and development;Rotation;screening;Sexually Transmitted Diseases;Site;South America;statistics;System;Technology;technology development;technology validation;Testing;Therapeutic;Training;training opportunity;Translations;Travel;Uganda;United States;United States National Institutes of Health;Universities;Validation;Veterans

PROJECT_TITLE: Point of Care Technologies for Nutrition, Infection, and Cancer for Global Health (PORTENT)


NIH_SPENDING_CATS: Bioengineering;HIV/AIDS;Nutrition

PI_NAMEs: ERICKSON, DAVID CARL (contact)

PROJECT_TERMS: academic program;Administrative Coordination;Advisory Committees;Biomedical Technology;Businesses;Clinical;clinical practice;clinical research site;Collaborations;college;commercialization;Conflict (Psychology);Consensus;cost efficient;Development;Diagnostic;Direct Costs;Domestic Partners;Ecology;Ecuador;Elements;Engineering;Ensure;Evaluation;experience;Foundations;Funding;Future;global health;Goals;Human;Human Resources;India;Industry;Infection;Infrastructure;innovation;Institution;Institutional Review Boards;International;Knowledge;Lead;Letters;Malignant Neoplasms;Manufacturer;Medical Device;meetings;multidisciplinary;Nature;Needs Assessment;new technology;New York;Nongovernmental Organizations;nutrition;operation;Point of Care Technology;Positioning Attribute;programs;Recommendation;Recording of previous events;Request for Applications;Request for Proposals;Research;Research Personnel;Resources;response;Scientist;Site;Structure;success;synergism;Technology;technology development;Training;Uganda;United States National Institutes of Health;Universities;Validation


NIH_SPENDING_CATS: Bioengineering;Cancer;Cervical Cancer;HIV/AIDS;Infectious Diseases;Nutrition;Prevention;Sexually Transmitted Infections;Women's Health Research

PROJECT_TERMS: Address;Anemia;C-reactive protein;Cancer and Nutrition;Cervical Cancer Screening;Clinical;clinical research site;Collaborations;commercialization;Consensus;Consultations;Decentralization;Detection;Development;Devices;Diagnostic;Direct Costs;DNA;early screening;Ecuadorian;Engineering;Evaluation;experience;Ferritin;Funding;Funding Opportunities;General Hospitals;global health;HIV;HPV-High Risk;Human Papillomavirus;Incubated;India;Infection;Information Dissemination;International;Iron;Lead;Leadership;Licensing;Malaria;Malignant Neoplasms;Marketing;Massachusetts;meetings;minimally invasive;multiplex detection;Needs Assessment;nutrition;Participant;point of care;Point of Care Technology;portability;Process;programs;prototype;Ramp;Readiness;Research Institute;Resource Allocation;Resources;Rotation;screening;Secure;Series;Serum;Sexually Transmitted Diseases;Structure;Technology;technology development;Testing;TFRC gene;Training;training opportunity;training project;Universities;Validation;Viral load measurement

PROJECT_TITLE: Technology Core


PI_NAMEs: MEHTA, SAURABH  (contact)

PROJECT_TERMS: Adoption;Area;biobank;Biometry;Budgets;Businesses;Clinical;Clinical Investigator;clinical practice;Clinical Research;clinical research site;clinical translation;Collaborations;commercialization;Communicable Diseases;Communities;Consensus;Coupled;Data Analyses;Data Management Resources;Databases;design;Development;Devices;Ecuador;experience;Funding;global health;Goals;Health;Human;improved;Incubators;India;Infection;International;Leadership;Learning;low and middle-income countries;Malignant Neoplasms;Needs Assessment;New York;New York City;Nongovernmental Organizations;nutrition;Nutritional status;Outcome;Outpatients;Participant;patient population;Patients;Phase;point of care;Point of Care Technology;point of care testing;point-of-care diagnostics;Population;prototype;Research Design;Research Infrastructure;Research Personnel;Research Support;Resources;Role;Rotation;Sample Size;Sampling;Site;Structure;success;Technology;technology development;Testing;tool;Training;training opportunity;Translations;Uganda;United States National Institutes of Health;Universities;Validation;validation studies;Work

PROJECT_TITLE: Clinical Core


PI_NAMEs: PAI, NITIKA  (contact)

PROJECT_TERMS: Address;Area;Clinical;Clinical assessments;clinical research site;Collaborations;commercialization;Communities;Consensus;Country;COVID-19 pandemic;design;Development;Devices;Diagnostic;diagnostic technologies;Disparate;Educational workshop;Elements;Engineering;experience;Focus Groups;global health;Goals;Health Personnel;Healthcare;Infection;Infrastructure;interest;International;Interview;Knowledge;low and middle-income countries;Malignant Neoplasms;Marketing;Methods;Modeling;Needs Assessment;New York City;Nongovernmental Organizations;novel;nutrition;Nutritionist;Outcome;Patients;point of care;Point of Care Technology;point-of-care diagnostics;Policy Maker;Process;program dissemination;programs;prototype;Qualifying;Qualitative Methods;Resources;Rotation;Scientist;Series;skills;Structure;Surveys;Technology;technology development;technology validation;Training;training opportunity;Universities;Validation;Vision

PROJECT_TITLE: Dissemination Core


ADMINISTERING_IC: AA

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Mental Illness;Prevention;Serious Mental Illness;Substance Misuse;Suicide;Suicide Prevention;Telehealth

ORG_CITY: DURHAM

ORG_DEPT: PSYCHIATRY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Recently discharged psychiatric inpatients who misuse alcohol are at high risk for suicide. The proposed project involves the development of a novel intervention that would enhance care for these individuals by pairing inpatient-based emotion regulation skills training with a mobile health application that extends this treatment into the post-discharge period. Through acquisition and eventual utilization of emotion regulation skills to replace maladaptive, stress-induced emotion-driven behaviors (e.g., heavy drinking, suicide attempts), this approach could reduce post-discharge risk for a suicide crisis and costly rehospitalization.

PI_NAMEs: GROVE, JEREMY  (contact)

PROGRAM_OFFICER_NAME: ROACH, DEIDRA

PROJECT_TERMS: acceptability and feasibility;Acute;acute care;Address;Admission activity;Adult;Alcohol consumption;alcohol misuse;alcohol related consequences;Alcohols;Ambulatory Care;Area;arm;Back;Behavior;Behavior Therapy;Behavioral;care seeking;career;Caring;Cessation of life;Client satisfaction;Clinical;Clinical Trials;Clinical Trials Design;Cognitive;cohort;cost;cost effective;Coupled;Dangerousness;Data;design;Development;Ecological momentary assessment;Educational Intervention;emotion regulation;Emotions;Environment;Evaluation;experience;Feedback;Feeling suicidal;follow-up;Goals;Health Services Accessibility;Heavy Drinking;high risk;high risk population;hospital readmission;Hospitalization;Individual;innovation;inpatient psychiatric treatment;inpatient service;Inpatients;Intervention;Life;Long-Term Care;Mentored Patient-Oriented Research Career Development Award;Mentors;Methodology;mHealth;Mobile Health Application;Modeling;Modification;National Institute of Mental Health;National Institute on Alcohol Abuse and Alcoholism;novel;novel strategies;Outcome;Outpatients;Participant;Patient Discharge;Patients;Persons;Phase;Prevalence;primary outcome;programs;Protocols documentation;psychiatric inpatient;Psychiatric therapeutic procedure;Public Health;public health priorities;Randomized;Randomized, Controlled Trials;Recommendation;Recovery;recruit;Reporting;Research;Research Personnel;Resolution;Risk;Risk Factors;Risk Reduction;Role;secondary outcome;skills;skills training;Societies;standard care;Statistical Models;Stress;suicidal;suicidal behavior;suicidal risk;Suicide;Suicide attempt;Suicide prevention;suicide rate;sustained recovery;therapy development;Time;tool;Training;treatment as usual;Treatment Efficacy;trial comparing;Underserved Population

PROJECT_TITLE: Development of mHealth-Supported Skills Training for Alcohol and Related Suicidality (mSTARS): Emotion Regulation Skills Training to Enhance Acute Psychiatric Care and Recovery

STUDY_SECTION: AA

STUDY_SECTION_NAME: Clinical, Treatment and Health Services Research Study Section[AA-3]


ADMINISTERING_IC: AT

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Complementary and Integrative Health;Dissemination and Implementation Research;Health Services;Neurosciences;Pain Research;Primary Health Care

ORG_CITY: SALT LAKE CITY

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Project Narrative Improving care for persons with chronic musculoskeletal pain is a priority in the Military Health System. The Military Health System is supporting a shift towards more holistic approaches to pain management. In this project we will evaluate two different interventions that provide holistic pain care; Empowered Relief and Move to Health. We will compare these two interventions and examine the effectiveness of a stepped care approach that sequences the two interventions based on a patient’s response. The results of this project will provide critical information and strategies to provide holistic pain management in the Military Health System.

PI_NAMEs: FRITZ, JULIE M (contact);RHON, DAN

PROGRAM_OFFICER_NAME: MURRAY, PETER DANIEL

PROJECT_TERMS: active duty;Address;Advocate;Articulation;Awareness;biopsychosocial;brief intervention;care delivery;Caring;Chronic Care;Chronic disability;chronic musculoskeletal pain;chronic pain;chronic pain management;chronic painful condition;Clinical Trials;comorbidity;compare effectiveness;comparison intervention;Complex;cost;Data Collection;Department of Defense;Dimensions;Disease;Educational process of instructing;effectiveness evaluation;effectiveness measure;Electronic Health Record;empowerment;Environment;Ethics;evidence base;Evidence based intervention;Future;Gender;Goals;Guidelines;Habits;Health;health management;Health Services;Health system;Healthcare;holistic approach;Holistic Health;Human Resources;Hybrids;implementation outcomes;implementation/effectiveness;improved;Individual;Integrative Medicine;Intervention;intervention cost;Manuals;Methods;military health system;Military Personnel;Modeling;Movement;Musculoskeletal;Nature;Nonpharmacologic Therapy;Outcome Study;Pain;Pain interference;Pain management;Pain Measurement;pain self-management;Patient Care;patient response;patient subsets;Patients;Persons;Phase;Policies;Pragmatic clinical trial;Preparation;primary care clinic;primary outcome;Procedures;programs;Provider;Randomized;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;Reporting;Research;Resources;response;Risk;Schedule;secondary outcome;Self Management;Service delivery model;service member;Site;skills;Societies;Surgeon;System;team-based care;Testing;Time;Training;treatment as usual;trial comparing;unhealthy lifestyle;uptake;Vision;whole health

PROJECT_TITLE: Holistic Pain Care in Military Health System

STUDY_SECTION_NAME: Special Emphasis Panel[ZAT1 MH (06)]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Fentanyl Misuse and Addiction;Lung;Neurosciences;Opioid Misuse and Addiction;Opioids;Prescription Drug Misuse;Substance Misuse

ORG_CITY: CHICAGO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CHICAGO

PHR: NARRATIVE This proposal seeks to establish hitherto unexplored role of carotid body activation by κ-opioid receptors and assess therapeutic potential of CB activation with co-application of κ-OR agonist(s) with fentanyl mitigated opioid-induced respiratory depression (OIRD), a major health problem in the USA.

PI_NAMEs: PRABHAKAR, NANDURI R (contact)

PROGRAM_OFFICER_NAME: LAPOSKY, AARON D

PROJECT_TERMS: Ablation;Affect;afferent nerve;Agonist;Analgesics;Animals;antagonist;Biochemical;Biological Assay;Blood Pressure;Brain Stem;Breathing;Carotid Body;cell type;Chemicals;Chemoreceptors;chronic pain;Clinic;Co-Immunoprecipitations;Data;delta opioid receptor;Exclusion;Exhibits;Fentanyl;fentanyl abuse;Gene Modified;Glomus Cell;Health;immunocytochemistry;indexing;inhibitor;innovation;insight;kappa opioid receptors;Knockout Mice;Measures;Messenger RNA;Molecular;mortality;Mus;neural;Neurons;novel therapeutic intervention;Opioid;Opioid Receptor;opioid use;Pain;Persons;Physiological;prevent;Proteins;Rattus;receptor;Receptor Activation;Research;respiratory;response;Role;sensory feedback;Signal Transduction;Site;System;Testing;Thapsigargin;Therapeutic;transcriptome sequencing;Ventilatory Depression;Western Blotting

PROJECT_TITLE:  opioid receptor activation of the carotid body mitigates OIRD by fentanyl

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Hematology;Immunization;Immunotherapy;Infant Mortality;Infectious Diseases;Orphan Drug;Pediatric;Primary Immunodeficiencies;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation;Vaccine Related

ORG_CITY: MINNEAPOLIS

ORG_NAME: NATIONAL MARROW DONOR PROGRAM

ORG_STATE: MN

PHR: Project Narrative Babies with severe combined immunodeficiency (SCID), a genetic disorder resulting in absence of T lymphocytes, die of infection by 2 years of age unless treatment with blood or bone marrow transplant is performed. This study will test whether transplantation with a low dose chemotherapy regimen will normalize the immune system of patients with common genetic subtypes of SCID identified at birth safely and effectively, avoiding the toxicity of high dose regimens currently in use. Results of this study can set a new standard for treatment of infants with SCID identified at birth, such that in the future, all babies with this otherwise fatal disease may live normal lives.

PI_NAMEs: AULETTA, JEFFERY J (contact);PULSIPHER, MICHAEL A

PROGRAM_OFFICER_NAME: MORRIS FEARS, MARGARET A

PROJECT_TERMS: 2 year old;adaptive immune response;Adoptive Transfer;Affect;Age;Allogenic;Antibody Response;Antigens;Antithymoglobulin;Area Under Curve;arm;B-Cell Development;B-Lymphocytes;Biological Markers;Biology;Birth;Blood;Bone Marrow Transplantation;Busulfan;CD19 gene;Cell Compartmentation;Cell Therapy;Chemotherapy-Oncologic Procedure;Childhood;Chimerism;Clinical;clinical outcome assessment;Clinical Trials;cohort;conditioning;COVID-19;curative treatments;Cytokine Signaling;Data;design;Development;Disease;dosage;Dose;efficacy testing;Elements;Engraftment;Enrollment;Ensure;exhaustion;Exhibits;fludarabine;follow-up;Funding;Future;gene therapy;Genetic;Genetic Diseases;Genotype;Goals;Graft Rejection;Grant;Hematopoietic;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;high risk;Host vs Graft Reaction;IGH@ gene cluster;IL2RG gene;Immune;immune reconstitution;Immune system;Immune Tolerance;Immunity;Immunoglobulins;improved;In Vitro;Infant;Infection;interleukin-21;JAK3 gene;Joints;Life;Lymphocyte;Mature T-Lymphocyte;Measures;Myelogenous;Myeloid Cells;Neonatal Screening;North America;novel;Opportunistic Infections;Oryctolagus cuniculus;Outcome;Output;Participant;Patients;Peripheral;Pharmacodynamics;pharmacokinetics and pharmacodynamics;primary endpoint;primary outcome;Process;progenitor;Prophylactic treatment;prospective;Protocols documentation;Rag1 Mouse;Randomized;randomized trial;Rare Diseases;Regimen;Regulation;Replacement Therapy;response;Risk;Safety;Sampling;Science;Severe Combined Immunodeficiency;Siblings;Source;standard care;standard of care;stem cell engraftment;stem cells;Subgroup;Survival Rate;Suspensions;T cell reconstitution;T-Cell Development;T-Cell Receptor;T-Lymphocyte;targeted treatment;Testing;Tetanus;Tetanus Vaccine;Therapy trial;Thiotepa;Thymus Gland;Toxic effect;Transplantation;transplantation therapy;trial design;vaccine immunogenicity;vaccine response

PROJECT_TITLE: Clinical and mechanistic studies defining optimal preparative approaches to infants with IL2RG/JAK3/RAG1/RAG2 SCID: a randomized trial of busulfan dosage

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 JTS-I (M3)]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: WEST HAVEN

ORG_NAME: VA CONNECTICUT HEALTHCARE SYSTEM

ORG_STATE: CT

PHR: The intersecting problems of high-impact chronic pain and the opioid overdose crisis continue to be major public health concerns that disproportionately impact veterans, and to address chronic pain and ineffective and potentially unsafe opioid use, interdisciplinary teams are recommended. While a biopsychosocial approach using non-pharmacological pain management strategies is becoming more common, an extension of this approach is the Whole Health Model of care, which promotes a whole-person approach emphasizing multiple determinants of health including the environment, emotional health, and social health, with a broader goal of overall well-being. In this proposal, we will evaluate the benefit of adding components of the Whole Health model, including Whole Health coaching to interdisciplinary pain care teams in a multisite pragmatic effectiveness-implementation hybrid type 2 trial, evaluating these approaches on the primary composite outcome of pain-related interference and opioid safety.

PI_NAMEs: BECKER, WILLIAM C;EDMOND, SARA  (contact);SEAL, KAREN H

PROJECT_TERMS: addiction;Address;Adult;Affect;American;Behavioral;Behavioral Medicine;biopsychosocial;budget impact;Buprenorphine;Caring;Centers for Disease Control and Prevention (U.S.);chronic pain;chronic pain patient;Clinic;Combined Modality Therapy;comorbidity;compare effectiveness;Connecticut;cost;cost comparison;Data;Development;Disparity;Effectiveness;effectiveness evaluation;effectiveness/implementation hybrid;effectiveness/implementation trial;Electronic Health Record;Emotional;Environment;Evaluation;Exhibits;experience;formative assessment;functional improvement;Goals;Guidelines;Health;health care model;health determinants;Healthcare Systems;high risk;hybrid type 2 trial;Hybrids;implementation cost;implementation evaluation;implementation facilitation;improved;Individual;Intervention;Interview;life span;Maintenance;Medicine;Methods;Modeling;multidisciplinary;multimodality;non-opioid analgesic;Opiate Addiction;Opioid;opioid overdose;Opioid Rotation;opioid tapering;opioid therapy;opioid use;Outcome;Pain;Pain management;Pain Measurement;pain outcome;participant enrollment;patient engagement;patient oriented;Patient Self-Report;Patients;Personal Satisfaction;Persons;Pharmaceutical Preparations;Phase;Physical Function;Physical Medicine;pragmatic randomized trial;pragmatic trial;Preparation;prescription opioid;Prevalence;Provider;Public Health;Randomized;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;Recovery;Research;Safety;safety outcomes;secondary outcome;Site;social;team-based care;Testing;Training;treatment as usual;Treatment Effectiveness;treatment planning;Veterans;Veterans Health Administration;whole health;Work

PROJECT_TITLE: Pain management teams using Whole Health to optimize function and safety in veterans: The TEAMWORK trial


ADMINISTERING_IC: OD

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Women's Health Research

ORG_CITY: WINSTON-SALEM

ORG_DEPT: PATHOLOGY

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative There is a national shortage of veterinarians in research. This renewal application seeks to provide five veterinary students per year with a summer fellowship designed to teach them about research methods, ethics, and the broad career opportunities in biomedical research.

PI_NAMEs: KAVANAGH, KYLIE  (contact)

PROGRAM_OFFICER_NAME: TANDON, RITESH

PROJECT_TERMS: Animals;Biology of Aging;Biomedical Research;Cardiovascular Diseases;career;comparative;Data Analyses;Dedications;Diabetes Mellitus;Educational process of instructing;Elements;Environment;Ethics;experience;Exposure to;Faculty;Fellowship;Grant;Health;Human;Hypertension;Immunology;improved;Journals;Malignant Neoplasms;medical schools;Medicine;Mentors;Neurobiology;nutrition;Operative Surgical Procedures;Oral;Pathology;Pharmacology;Physiology;Positioning Attribute;Productivity;programs;Publishing;radiation countermeasure;Reporting;Reproductive Medicine;Research;Research Methodology;Research Personnel;Research Project Grants;Research Proposals;Rheumatology;school environment;Scientist;skills;Structure;Students;summer research;Training;Training Programs;translational medicine;translational model;Universities;Veterinarians;Veterinary Education;Veterinary Schools;Women's Health;Writing

PROJECT_TITLE: Summer Veterinary Student Research Fellows at Wake Forest University

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-J (80)]


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Social Determinants of Health

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: NARRATIVE As part of our proposal for a “Consortium for Translational Precision Health”, this K12 program seeks to train early-career faculty members in translational science, to help bring the benefits of scientific discoveries into clinical practice and the health of communities. Scholars in our two-year training program, with an optional third year, will conduct mentored research and obtain training in precision health, translational science, leader- ship, and professional skills, aimed at developing the next generation of academic leaders.

PI_NAMEs: BRUCE, MARINO A;GRIGORENKO, ELENA L;PEREIRA, FRED A;RUMBAUT, ROLANDO E (contact)

PROGRAM_OFFICER_NAME: GOPAL-SRIVASTAVA, RASHMI

PROJECT_TERMS: Artificial Intelligence;Behavioral Sciences;Bioinformatics;Biomedical Engineering;Biotechnology;Businesses;career development;Cities;college;Common Core;Communities;Companions;Competence;computer science;Devices;digital health;Discipline;Doctor of Philosophy;early-career faculty;Educational Curriculum;Enrollment;Environment;Faculty;Genetic;Geography;Health;health determinants;health disparity;health equity;Health Promotion;Health Sciences;Human;implementation science;innovation;Institution;Machine Learning;Mathematics;Medical Research;Medicine;member;Mentored Clinical Scientist Development Program;Mentors;Minority-Serving Institution;multiple omics;next generation;Pharmacy facility;Physicians;population health;Precision Health;programs;Qualifying;Recording of previous events;recruit;Research;research and development;Scientist;Surgeon;synergism;Time;Training;Training Programs;Translational Research;Universities

PROJECT_TITLE: CTSA K12 Program at Baylor College of Medicine and University of Houston

STUDY_SECTION_NAME: Special Emphasis Panel[ZTR1 CI-7 (01)]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: The Advancing Cancer Control Engaged Research Through Transformative Solutions in Patient Navigation (ACCERT PN) Center will develop community-engaged interventions, measures and methods for process and outcomes assessment, and researcher and community partner capacity and engagement centered around the theme of innovative multilevel Patient Navigation approaches and implementation science to address language accessibility, health literacy, and other determinants of health – with the goal of mitigating low access to care and poor cancer health outcomes experienced by individuals from many Chicago area communities. The ACCERT PN Center’s research program will be supported by an Administrative Core and a Research Methods, Measures, and Data Management Core.

PI_NAMEs: SIMON, MELISSA A. (contact);YANEZ, BETINA

PROGRAM_OFFICER_NAME: TESAURO, GINA M

PROJECT_TERMS: Address;Adult;Advanced Malignant Neoplasm;anti-racism;Artificial Intelligence;Artificial Intelligence enhanced;Behavioral Sciences;Black race;black women;cancer care;Cancer Control;Cancer Etiology;Cancer health equity;Cancer Survivorship;care delivery;Caring;Chicago;Chinese;Chinese population;Cities;Clinical;Communication;Communities;community academic partnership;community based participatory research;community engaged intervention;community engagement;community partners;community setting;computer human interaction;data management;design;Development;digital;Disadvantaged;Discrimination;effectiveness-implementation randomized trial;Engineering;Equity;Ethnic Origin;Evaluation;Evidence based intervention;experience;Goals;health equity;health inequalities;health literacy;Health Personnel;Health system;Healthcare;Hybrids;implementation science;implementation strategy;improved;Incidence;Inequity;innovation;intelligent agent;Intervention;Intervention Studies;Language;Latinx;Learning;Link;literacy;Lived experience;Low income;Malignant Neoplasms;Measures;Methods;mortality;Oncology;Outcome;Outcome Assessment;Pathway interactions;Patient advocacy;Patient Education;patient engagement;patient navigation;Patients;Process;Process Assessment;programs;Provider;Race;racism;Recording of previous events;Records;recruit;Research;Research Methodology;Research Personnel;Research Project Grants;Resources;response;segregation;Sexuality;social assistive robot;social health determinants;social influence;Structural Racism;System;Testing;tool;Training;Underrepresented Populations;Work

PROJECT_TITLE: Advancing Cancer Control Equity Research Through Transformative Solutions in Patient Navigation (ACCERT PN)

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 RTRB-F (M1)]


NIH_SPENDING_CATS: Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention

PI_NAMEs: SIMON, MELISSA A. (contact)

PROJECT_TERMS: Advanced Malignant Neoplasm;anti-cancer research;Black race;Cancer Control;Cancer health equity;career;career development;Chicago;Chinese;Clinical;Collaborations;Communication;Communities;community advisory board;community center;community collaboration;community engaged research;community engagement;community engagement process;Community Participation;community partners;community research;Comprehensive Cancer Center;conflict resolution;Data Analyses;design;Doctor of Philosophy;Ecosystem;Ensure;Environment;Equity;Evaluation;experience;Fostering;Goals;Grant;Growth;health inequalities;infrastructure development;innovation;Institution;Intervention;Latinx;Leadership;Low income;Malignant Neoplasms;Measures;medical schools;meetings;member;Mission;novel;Office of Administrative Management;operation;patient navigation;Pilot Projects;Procedures;Process;Productivity;programs;recruit;Reporting;Research;Research Activity;Research Personnel;Research Project Grants;Resource Allocation;Resource Sharing;Resources;Scientist;skills;Structure;tool;Universities

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: YANEZ, BETINA  (contact)

PROJECT_TERMS: Address;Adoption;Advanced Malignant Neoplasm;anti-racism;Asian;Black race;Cancer Control;Cancer Control Research;Cancer Survivorship;Chicago;Chinese;Chinese American;Clinical;Collaborations;Communication Tools;Communities;community based participatory research;community collaboration;community engagement;community engagement process;community partners;Comprehensive Cancer Center;cost;Data;Data Analyses;Data Collection;data management;data sharing;design;Development;digital health;Discrimination;Doctor of Philosophy;Effectiveness of Interventions;effectiveness outcome;Ensure;Environment;Equity;Ethics;Evaluation;Foundations;Future;Goals;Health;health equity;health equity promotion;health inequalities;health literacy;Health system;Healthcare Systems;implementation determinants;implementation efforts;implementation framework;implementation outcomes;implementation science;Incubators;innovation;Intervention;Latina;Latinx;Learning;Low income;Maintenance;Malignant neoplasm of prostate;Malignant Neoplasms;Measurement;Measures;Medical;medical schools;Methods;Midwestern United States;Modeling;Outcome;patient navigation;Phase;Policies;Preventive service;Process;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Research;Research Activity;Research Methodology;Research Project Grants;Research Support;Resource Sharing;Resources;Running;Science;Scientific Advances and Accomplishments;Sexual Health;social health determinants;Sum;synergism;Training;United States National Institutes of Health;Woman;Work

PROJECT_TITLE: Research Methods, Measures, and Data Management Core


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Machine Learning and Artificial Intelligence;Palliative Care;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

PROJECT_TERMS: Address;Adult;Advanced Malignant Neoplasm;Artificial Intelligence;Artificial Intelligence enhanced;barrier to care;Black race;cancer care;Cancer Control;Cancer Etiology;cancer health disparity;Cancer Patient;cancer type;care delivery;Caring;case-by-case basis;Cause of Death;chatbot;Chicago;Chinese;clinical encounter;Communication;Communities;community academic partnership;community center;community organizations;community partners;compare effectiveness;Decision Making;design;Diagnostic;Discrimination;distrust;effectiveness-implementation randomized trial;effectiveness/implementation trial;Eligibility Determination;Engineering;Equity;ethnic disparity;Ethnic Origin;Evaluation;Event;Evidence based intervention;experience;Face;Feedback;follow-up;Goals;Health care facility;health care service;health inequalities;health literacy;Health Services;Health system;Healthcare;Hybrids;implementation determinants;implementation evaluation;implementation outcomes;implementation science;implementation strategy;implicit bias;improved;Individual;innovation;intelligent agent;Intervention;Language;Latinx;Learning;Low income;Malignant Neoplasms;maltreatment;Medical;Methods;Minority Groups;Modeling;Neighborhoods;novel;Oncology;Outcome;Patient Education;patient navigation;patient oriented;patient-clinician communication;Patients;Preventive screening;Preventive service;Provider;Quality of Care;Race;racial disparity;racism;Recommendation;recruit;Reporting;Research;Research Project Grants;Right to Treatments;screening;Services;Site;social;social health determinants;Social Work;Spanish;Structural Racism;Supportive care;System;team-based care;Technology;Testing;Time;tool;Touch sensation;Trust;United States Preventative Services Task Force;verbal

PROJECT_TITLE: Advancing Innovations in Patient Navigation and Implementation Science to Address Structural Racism and Social Determinants of Health


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Prevention;Racial and Ethnic Minority Health Research;Rehabilitation;Social Determinants of Health

PI_NAMEs: LEWIS, MARQUITA W. (contact)

PROJECT_TERMS: access disparities;Access to Information;Address;Advanced Malignant Neoplasm;Area;arm;Artificial Intelligence;Black race;black women;cancer care;Cancer Control;cancer health disparity;Cancer Patient;Cancer Survivor;cancer survivorship care;cancer therapy;care delivery;Caring;CEBPE gene;Chicago;Chinese;Chinese American;Clinical;Communication;Communities;community advisory board;community center;community engaged intervention;community engagement process;community partners;community setting;Computers;Data;data management;digital;digital divide;digital health;digital technology;Doctor of Philosophy;Ecosystem;Educational workshop;Emotional;Empathy;empowerment;Equilibrium;Equity;experience;Fostering;Foundations;Funding;Funding Mechanisms;Goals;Grant;Health behavior;Health equity research;health inequalities;health literacy;Health Personnel;Health Services Accessibility;Health system;Human;human centered design;implementation science;improved;innovation;Intervention;iterative design;Knowledge;Language;Latinx;Learning;literacy;Literature;Lived experience;Low income;Malignant Neoplasms;Measures;Methods;Minority-Serving Institution;Modeling;neglect;outreach;Participant;patient engagement;patient navigation;patient navigator;patient-clinician communication;Patients;Peer Review;Pilot Projects;preference;Process;programs;Provider;recruit;Research;Research Methodology;Research Personnel;Research Project Grants;Resources;Role;satisfaction;Scientist;Self Disclosure;Sexual Health;Side;social assistive robot;social health determinants;Social support;Structural Racism;Survivors;Testing;therapy design;three-arm trial;Time;tool;Training;United States National Institutes of Health;Universities;willingness;Woman

PROJECT_TITLE: Advancing Cancer Control Equity Research Through Transformative Solutions in Patient Navigation - Community Responsive Projects


NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Mental Illness;Pediatric;Post-Traumatic Stress Disorder (PTSD);Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PUBLIC HEALTH RELEVANCE Maternal mental illness can adversely modify the developmental trajectory of the child and is a significant contributor to maternal mortality in the U.S. A significant portion of women can experience traumatic childbirth, and some will develop posttraumatic stress disorder (PTSD), although this condition remains underdiagnosed and undertreated. This study will define the course and predictors of maternal childbirth-related PTSD and its effects on the child and lay the foundation for preventive and holistic care for both mother and child.

PI_NAMEs: DEKEL, SHARON  (contact)

PROGRAM_OFFICER_NAME: CHAKHTOURA, NAHIDA ABDO

PROJECT_TERMS: Accidents;Address;Affect;American;American College of Obstetricians and Gynecologists;Animal Model;antenatal;assault;Behavioral;Biological;Biological Markers;Birth;Breast Feeding;candidate identification;Caring;Child;Child Development;Child Welfare;Childbirth;Chronic;Clinical;Cognition;Cognitive;cohort;combat;Communication;cost;Data;Development;Diagnosis;Dimensions;Discipline of obstetrics;Disease;DSM-V;Early Intervention;early screening;Emotional;emotional distress;Enhancers;Epigenetic Process;ethnic disparity;ethnic health disparity;Ethnic Origin;experience;Exposure to;Foundations;Goals;Growth;Health;health disparity;Hour;Imagery;Impairment;improved;Infant;infant temperament;insight;intergenerational;Investigation;Knowledge;Knowledge acquisition;Life;longitudinal, prospective study;low socioeconomic status;Maternal Deprivation;Maternal Health;maternal morbidity;Maternal Mortality;Measurement;Measures;Mediating;Medical;Medical Records;Mental Depression;Mental disorders;Mental Health;Mental Health Services;mental imagery;Military Personnel;Minority Women;Mission;Modification;Morbidity - disease rate;Mother-Child Relations;Mothers;Motor;National Institute of Child Health and Human Development;neonatal period;Neurotic Disorders;obstetrical complication;Outcome;patient stratification;Perception;Perinatal;Physiological;Post-Traumatic Stress Disorders;Postpartum Depression;Postpartum Period;Pregnancy;Pregnant Women;prepregnancy;prevent;Preventive;Procedures;Productivity;programs;prospective;protective factors;Provider;Psyche structure;psychologic;Psychometrics;Psychopathology;Psychophysiology;public health relevance;Quality of Care;racial discrimination;racial disparity;racial health disparity;Recommendation;Reduce health disparities;Reproductive Process;response;Risk;Risk Factors;Role;Schedule;screening;Security;social determinants;Social support;societal costs;Standardization;stem;Stress;stressor;Symptoms;Testing;Therapeutic Intervention;Third Pregnancy Trimester;Time;tool;Trauma;trauma exposure;traumatic event;traumatic stress;Validation;welfare;Well in self;Woman;Work

PROJECT_TITLE: Childbirth trauma and maternal PTSD: Examining racial and ethnic disparities in maternal mental health

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

ORG_CITY: MILWAUKEE

ORG_NAME: NANOAFFIX SCIENCE, LLC

ORG_STATE: WI

PHR: PROJECT NARRATIVE The NanoAffix Science, LLC Commercialization Readiness Pilot (CRP) Program project aims to continue the development of a handheld lead tester for accurate and low-cost onsite detection of total lead in drinking water by non-technical experts, based on the success of the Phase II project. The project will further NanoAffix’s mission to increase the accessibility of quantitative water quality monitoring with strategic development and refinement of the product. NanoAffix will continue product development to improve performance and ease of use, scale up manufacturing beyond pilot scale production, obtain product and method certifications from relevant organizations, and engage in market research and planning to better understand our target markets.

PI_NAMEs: HILL, JAMES CURTIS (contact)

PROGRAM_OFFICER_NAME: HENRY, HEATHER F

PROJECT_TERMS: Acute;Address;Aging;Bluetooth;Businesses;Cells;Certification;Child;Chronic;commercialization readiness;Communication;Complex;Consult;Contracts;cost;Data;Detection;detector;Development;Devices;Diagnostic Reagent Kits;drinking water;economic impact;Elbow;Equipment;Exposure to;Feedback;Film;Focus Groups;Foundations;Frequencies;graphene;hazard;Health;high risk;improved;Industry;Infrastructure;insight;Interview;Laboratories;Lead;lead contamination;Lead Poisoning;Learning;Leeches;Location;manufacture;Manufacturer;manufacturing scale-up;Market Research;Marketing;Measures;meter;Methods;Minor;Mission;nanoscale;nanosensors;Nervous System Trauma;novel;Paper;Participant;Particulate;Performance;Phase;Pilot Projects;portability;product development;Production;programs;Protocols documentation;prototype;Public Health;rapid detection;Readiness;Reporting;Research;Resources;Sales;sample collection;Sampling;Sanitation;Science;sensor;service providers;Services;Site;Small Business Innovation Research Grant;smartphone application;Source;Specialist;success;Technology;Test Result;test strip;Testing;Thinness;Toxic effect;Training;United States;United States Environmental Protection Agency;Update;Validation;virtual;Water;water testing;Work

PROJECT_TITLE: Graphene-based Nanosensor Device for Rapid, Onsite Detection of Total Lead in Tap Water

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-B (19)]


ORG_CITY: Decatur

ORG_NAME: VETERANS HEALTH ADMINISTRATION

ORG_STATE: GA

PHR: Glaucoma is the leading cause of irreversible blindness globally. Prevalence is greater among Veterans than in the general population and is increasing dramatically. Women Veterans and blast injury survivors are particularly susceptible. Current treatments work well early, but often fail over time. Given the aging Veteran population, there is thus an urgent need to develop new treatment strategies for late-stage disease. We recently developed a drug, HIOC, to protect against loss of retina ganglion cells due to blast injury. These are the same cells whose death in glaucoma causes blindness. We propose to test whether HIOC protects retina cells and vision in mouse models of glaucoma. As we have done successfully with other drugs we brought to clinical trial, this project is designed to test critical in vivo responses and mechanisms of action that will provide preclinical data in support of our proposing ophthalmic clinical trials of HIOC, a potentially inexpensive and accessible treatment for Veterans suffering from a chronic disease that results in blindness.

PI_NAMEs: BOATRIGHT, JEFFREY H (contact)

PROJECT_TERMS: Age;Aging;analog;antagonist;Anterior;Aqueous Humor;Blast Injuries;Blindness;Blood-Retinal Barrier;Brain;Brain-Derived Neurotrophic Factor;Cell Physiology;Cells;Cessation of life;Chronic;Chronic Disease;Clinic;Clinical Trials;Data;design;Disease;Disease Progression;Dose;effective therapy;epidemiology study;Etiology;experimental study;Eye;General Population;Glaucoma;Half-Life;Health;high risk;Hour;Human;human disease;in vivo;insight;Intraperitoneal Injections;Mediator;men;Microspheres;military veteran;Modeling;Monitor;Morphology;mouse model;Mus;nerve damage;neuroprotection;neurotrophic factor;Neurotrophic Tyrosine Kinase Receptor Type 2;novel strategies;novel therapeutic intervention;Ocular Hypertension;old mice;Optic Nerve;Outcome;Patient Compliance;Patients;Pharmaceutical Preparations;Phosphorylation;Phosphotransferases;Physiologic Intraocular Pressure;pigment dispersion syndrome;pre-clinical;Predisposition;Prevalence;receptor;Recombinants;Refractory;Reporting;response;Retina;retinal axon;retinal damage;Retinal Ganglion Cells;Risk Factors;small molecule;standard of care;success;Survivors;Testing;Time;Topical application;Toxicology;Translating;Veterans;Vision;Visual;Visual impairment;Woman;Work

PROJECT_TITLE: A TrkB Activator for Treatment of Glaucoma

STUDY_SECTION_NAME: Sensory Systems & Communication Disorders[RRD3]


NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Brain Disorders;Clinical Research;Disability Research;Health Services;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Prevention;Primary Health Care

ORG_CITY: ATLANTA

ORG_DEPT: PEDIATRICS

ORG_NAME: EMORY UNIVERSITY

PHR: PROJECT NARRATIVE In this project, we will measure the clinical utility of an objective and quantitative eye-tracking assay collected on a standalone, mobile investigational device to accurately screen 9-month-old infants for autism spectrum disorder and other actionable developmental delays. We will recruit a large cohort of infants from primary care pediatric practices and follow them longitudinally for clinical ascertainment at outcome. Our goal is to develop a community-viable methodology for early ASD screening, thus affording at-risk and affected children with the opportunity to access, and benefit from, early intervention services during periods of maximal neuroplasticity.

PI_NAMEs: JONES, WARREN  (contact)

PROGRAM_OFFICER_NAME: GILOTTY, LISA

PROJECT_TERMS: Affect;Age;Age Months;Agreement;autism spectrum disorder;autistic;Biological Assay;Blinded;Calibration;Child;Child health care;Childhood;Clinical;cognitive ability;cognitive skill;cohort;Communities;cost effective;Data;Data Analytics;Data Collection;design;Development;Developmental Delay Disorders;Devices;Diagnosis;diagnosis standard;Diagnostic;Diagnostic Sensitivity;Dimensions;Disability scale;Double-Blind Method;Early Intervention;Effectiveness;efficacy testing;Enrollment;Evaluation;experience;General Population;Goals;Improve Access;indexing;Individual;infancy;Infant;instrument;Language;Learning;Measurement;Measures;Methodology;Methods;Modeling;National Institute of Mental Health;Neuronal Plasticity;non-verbal;Outcome;Performance;Physicians;Population;population based;Predictive Value;Primary Care;primary care practice;Procedures;recruit;Reference Standards;Research Design;response;Risk;Risk Assessment;Sampling;screening;Screening procedure;secondary analysis;Sensitivity and Specificity;Series;service intervention;Severities;social;Social disability;Specific qualifier value;Specificity;Standardization;Symptoms;Technology;Testing;Time;tool;Translations;Validation;verbal;Visual;visual tracking;Well Child Visits

PROJECT_TITLE: Community-viable screening for ASD in 9-month-old infants using quantitative eye-tracking assays of social visual engagement


ORG_NAME: DURHAM VA MEDICAL CENTER

PHR: Posttraumatic stress disorder (PTSD) is prevalent among military Veterans and is more than just a psychological condition; PTSD has profound negative impacts on health, function, and quality of life. Older Veterans are the largest patient population served by the Veterans Health Administration (VHA), and many have lived with PTSD for 30+ years. Veterans with PTSD engage in low levels of physical activity and spend much of their time in sedentary activities, adding to their risk of physical disability. The benefits of exercise on mental health and physical well-being in older adults are well-substantiated, but the effects of exercise training on late-life PTSD symptoms is a new area of study. This study is designed to examine the effects of 6 months of supervised exercise training on PTSD symptoms and PTSD-related conditions (e.g., functional impairment, sleep) in older Veterans with chronic PTSD. This study speaks directly to VHA’s mission and emphasis on non- pharmacologic approaches to improve mental health and well-being of older Veterans with chronic PTSD.

PI_NAMEs: HALL, KATHERINE SHEPHERD (contact)

PROJECT_TERMS: Aerobic;Aerobic Exercise;Affect;Afghanistan;age acceleration;Age Years;Aging;Area;arm;attentional control;Attenuated;behavior change;Behavior Therapy;Behavioral;Bicycling;Biological;Caring;Chronic;Chronic Disease;Chronic Post Traumatic Stress Disorder;Cognition;Cognitive;cognitive function;cognitive performance;cohort;comorbidity;Complex;Control Groups;daily functioning;Data;Death Rate;deconditioning;depressive symptoms;design;disability;Disease Management;Educational Curriculum;effective therapy;Electronic Mail;Elements;endurance exercise;Equilibrium;Excess Mortality;Exercise;exercise capacity;exercise intervention;exercise prescription;exercise program;exercise training;experience;flexibility;follow-up;Functional impairment;functional outcomes;Future;Gait speed;General Population;Health;Health education;Health Promotion;Health Status;Health system;healthy aging;Impairment;improved;improvement on sleep;Individual;interest;intervention effect;Iraq;Joints;late life;Leg;Linear Models;Literature;Measures;Mediating;Mental Depression;Mental disorders;Mental Health;meter;military veteran;Mission;Modeling;modifiable risk;Monitor;mortality;Motivation;Muscle;Neck;Newsletter;Nonpharmacologic Therapy;Obesity;older adult;Outcome;Outcome Study;Participant;Pathway interactions;patient oriented;patient population;patient retention;Patients;peer;Personal Satisfaction;Physical activity;physical conditioning;Physical Function;Physical Performance;physically handicapped;Pilot Projects;Population;post intervention;Post-Traumatic Stress Disorders;preference;Prevention strategy;primary outcome;programs;Protocols documentation;psychologic;psychosocial;Publishing;Quality of life;Randomized;randomized controlled design;randomized trial;Randomized, Controlled Trials;Recording of previous events;recruit;Reporting;Research;Research Personnel;resilience;Risk;Risk Factors;Sampling;secondary outcome;sedentary activity;Series;service member;Sleep;sleep quality;Specialist;strength training;Structure;Symptoms;telehealth;Testing;Theoretical model;therapy development;Time;Training;Training Programs;treadmill;treatment arm;two-arm study;Veterans;Veterans Health Administration;Vietnam;Walking;webinar;Work

PROJECT_TITLE: Exploring the Effects of Exercise Training on PTSD Symptoms and Physical Health in Older Veterans with PTSD

STUDY_SECTION_NAME: Chronic Medical Conditions & Aging[RRD6]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: KANSAS CITY

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: PROJECT NARRATIVE  Cells adjust their protein degrading capacity to adapt to different forms of stress by upregulating, removing, or relocating proteasomes. As both the ability to degrade proteins and several of the regulatory factors have been implicated in human diseases, it is critical to obtain a molecular understanding of these processes. The proposed work will utilize the model organism S. cerevisiae, human cells, and in vitro assays to understand the molecular mechanisms that drive these conserved processes.

PI_NAMEs: ROELOFS, JEROEN  (contact)

PROGRAM_OFFICER_NAME: PHILLIPS, ANDRE W

PROJECT_TERMS: Aging;Biochemical;biological adaptation to stress;Biological Assay;Cell Physiology;Cells;Complex;Foundations;Goals;Growth;Heat Stress;Homeostasis;Human;human disease;in vitro Assay;in vivo;insight;Knowledge;Liquid substance;Malignant Neoplasms;model organism;Molecular;multicatalytic endopeptidase complex;Neurodegenerative Disorders;Oxidative Stress;Pathway interactions;Pharmaceutical Preparations;Phase;Physical condensation;Process;Proteins;Research;response;Saccharomyces cerevisiae;Saccharomycetales;Stress;Testing;Therapeutic;tissue culture;Transcriptional Regulation;Ubiquitination;Up-Regulation;Work;Yeasts

PROJECT_TITLE: Proteasome homeostasis and substrate prioritization


ORG_NAME: UNIVERSITY OF MINNESOTA

PHR: PROJECT NARRATIVE Maternal immunity and microbial experience shape fetal immune development. Mechanistic understanding of how normal microbial experiences are communicated to the developing fetus is limited by the common practice of raising animal models in artificially hygienic specific pathogen free conditions. This proposal uses an innovative microbial normalization model whereby female mice are exposed to diverse microbial communities through cohousing with pet store mice prior to conception and throughout gestation to gain critical insight into the effects of maternal microbial exposure on fetal immune development and the mechanisms by which microbial encounters are communicated between maternal and fetal immune systems.

PI_NAMEs: SCHULDT, NATHAN  (contact)

PROGRAM_OFFICER_NAME: MAJJI, SAI PRASANNA

PROJECT_TERMS: Adult;Affect;Animal Model;Biological Assay;Biological Markers;Biological Models;Biometry;Birth;Breeding;Calibration;Cell secretion;Cells;Circulation;Coculture Techniques;Communication;Complex;Conceptions;congenic;coping;Data;Development;Disease;embryo/fetus antigen;Ensure;Environment;Equilibrium;experience;experimental study;Exposure to;Extracellular Space;extracellular vesicles;Failure;Female;fetal;Fetal Development;fetal infection;fetal loss;Fetal Tissues;Fetus;Flow Cytometry;Future;germ free condition;Hematopoiesis;Hematopoietic;Host Defense;Human;Immune;immune function;Immune response;Immune system;Immunity;Immunohistochemistry;Immunological Models;Immunologics;Immunology;immunoregulation;Immunosuppression;Impairment;improved;In Vitro;Infection;Inflammation;innovation;insight;Knowledge;Laboratory mice;Life;Lipid Binding;Mass Spectrum Analysis;Maternal antibody;maternal immune system;Maternal-Fetal Exchange;Maternally-Acquired Immunity;Measures;Microbe;microbial;microbial community;Microchimerism;MicroRNAs;Modeling;mortality;Mothers;mouse model;Mouse Strains;Mus;Nature;Neonatal Mortality;Newborn Infant;novel;offspring;Organ;Output;particle;pathogen;Pathology;Perinatal;Physiological;Placenta;Pre-Clinical Model;Pregnancy;pregnancy immunology;pregnant;Premature Birth;preservation;prevent;Prevention;Prevention strategy;Process;Proteins;Research;Resources;Risk;risk minimization;Shapes;Spontaneous abortion;T-Lymphocyte;Techniques;Testing;Time;tool;trafficking;transcriptome sequencing;treatment strategy;Work

PROJECT_TITLE: Microbial-induced maternal factors that influence fetal immune development

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-EMS-E(55)R]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging

ORG_CITY: Los Angeles

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

ORG_STATE: CA

PHR: Here we propose to develop a platform technology for 3-D printing of complex optical devices and engage it for the development of High Performance Functional Volumetric Snapshot OCT.

PI_NAMEs: APPLEGATE, BRIAN E. (contact);TKACZYK, TOMASZ S

PROGRAM_OFFICER_NAME: YEH, ALVIN TIEN-WEI

PROJECT_TITLE: Ultra-stable, phase sensitive, snapshot OCT system enabled by 2-Photon additive manufacturing

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-P(81)S]


ADMINISTERING_IC: MD

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: EL PASO

ORG_NAME: UNIVERSITY OF TEXAS EL PASO

PHR: Project Narrative This study will test the effectiveness of employer-based multilevel walking challenge intervention El Paso County, Texas, a predominantly Mexican American urban area. If successful this intervention could be disseminated as a primary prevention strategy to reduce cardiometabolic health disparities in this population.

PI_NAMEs: SALINAS, JENNIFER J. (contact)

PROGRAM_OFFICER_NAME: GILLMAN, ARIELLE SAMANTHA

PROJECT_TERMS: Achievement;adaptive intervention;Address;Adherence;Area;Behavior Therapy;Behavioral;Cardiometabolic Disease;cardiometabolism;compare effectiveness;cost;cost effectiveness;Cost Effectiveness Analysis;County;Disease;Disparity;Dose;Economic Burden;Economics;Effectiveness;effectiveness evaluation;effectiveness testing;Employee;ethnic minority population;Evaluation;evidence base;Evidence based intervention;Evidence based practice;Exhibits;Family;Goals;Guidelines;Health;Health Benefit;health disparity;health equity;Health equity research;Health Sciences;Hispanic-serving Institution;improved;Individual;innovation;insight;Intervention;Knowledge;Life;Malignant Neoplasms;Measures;meetings;Metabolism;Mexican Americans;Mexico;Modeling;Monitor;Motivation;Not Hispanic or Latino;Occupations;Participant;Phase;Physical activity;Population;prevent;Prevention strategy;Primary Prevention;process evaluation;Productivity;professional atmosphere;programs;Public Health;Random Allocation;Recommendation;Research Personnel;Resources;response;satisfaction;school district;Schools;Sequential Multiple Assignment Randomized Trial;Testing;Texas;Text Messaging;Time;trial design;United States;Universities;urban area;vigorous intensity;Walking;walking intervention;Wellness Program;Work;Workplace

PROJECT_TITLE: Evidence-based intervention to improve walking engagement in El Paso, Texas


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Anorexia;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Eating Disorders;Mental Health;Mental Illness;Neurosciences;Nutrition;Serious Mental Illness

ORG_DEPT: PSYCHOLOGY

PHR: Project Narrative Anorexia Nervosa (AN) is a serious and sometimes deadly psychiatric illness characterized by distortions in valuation for food that drive rigid and stereotyped food choices and lead to dangerously low body weight. We propose to examine the cognitive and neural mechanisms that underlie subjective food value construction that drive maladaptive food choices in AN using state-of-the-art cognitive neuroscience methods and computational modeling to determine how this process arises and how it can be biased to normalize decisions about what to eat. The proposed studies will develop a new pathway for understanding and treating the salient behavior of restrictive eating that contributes to the significant disease burden of Anorexia Nervosa.

PI_NAMEs: BAKKOUR, AKRAM  (contact);WILDES, JENNIFER E

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: Address;Anorexia Nervosa;Attention;attentional bias;base;Behavior;behavior measurement;Behavioral;Behavioral Research;Body Weight;Brain;burden of illness;Calories;Categories;Choice Behavior;Cognitive;cognitive neuroscience;Computer Models;Cues;Dangerousness;Death Rate;Decision Making;Development;Disease remission;Eating;Eating Disorders;Fatty acid glycerol esters;Food;Food Preferences;Fruit;Functional Magnetic Resonance Imaging;Goals;Health Food;Image;Individual;innovation;Intervention;Macronutrients Nutrition;Measures;Mental disorders;Methods;neural;neuromechanism;Neurosciences;novel;Outcome;Participant;Pathway interactions;Pattern;Persons;preference;Process;Proteins;Reaction Time;Relapse;Research;restrictive eating;Sampling;Savory;Services;Stereotyping;Symptoms;System;Testing;theories;therapy design;Training;Vegetables;visual tracking

PROJECT_TITLE: Constructing the subjective value of food in Anorexia Nervosa

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


FUNDING_MECHANISM: OTHERS

ORG_CITY: BIRMINGHAM

ORG_NAME: BIRMINGHAM VA MEDICAL CENTER

ORG_STATE: AL

PHR: Spinal cord injury (SCI) affects approximately 40,000 Veterans and leads to healthcare costs of $525,000 for the first year after SCI and $80,000 each year thereafter. This provides a strong justification to find treatments which help reduce the financial burden facing Veterans with SCI while also increasing their well-being. Skeletal muscle function and health are severely reduced after SCI and this is associated with negative health factors such as insulin resistance, inflammation and obesity. Protecting mitochondrial health after paralysis may be a way to preserve muscle health after SCI. There are no FDA-approved treatments to preserve mitochondrial health. Investigating whether the appearance of connexin hemichannels in muscle after SCI is linked to mitochondrial health may provide an avenue for future drug design. Testing current drugs for improving mitochondrial health, such as SS-31, can provide essential information regarding how best to improve the health of Veterans with SCI.

PI_NAMEs: GRAHAM, ZACHARY AARON (contact)

PROJECT_TERMS: Address;Affect;Animals;Antioxidants;Appearance;Architecture;behavior test;Biochemical;Calcium;Cellular Stress;Chronic;clinical investigation;cohort;Connexin 43;Connexins;Data;Dietary Intervention;Drug Design;drug development;Drug Targeting;Electron Microscopy;Enterobacteria phage P1 Cre recombinase;extensor digitorum;extracellular;FDA approved;Female;Financial Hardship;Future;Gastrocnemius Muscle;Gene Expression;Genotype;Health;Health Care Costs;Homeostasis;improved;Individual;Inflammation;Injections;Injury;insight;Insulin;Insulin Resistance;Intervention;Investigation;Knock-out;Link;LoxP-flanked allele;male;Measures;Medicine;Metabolic;metabolomics;Mitochondria;mitochondrial dysfunction;Morphology;Motor;mouse model;Mus;Muscle;Muscle Fibers;muscle form;Muscle function;Muscle Mitochondria;Muscular Atrophy;novel;Obesity;OPA1 gene;Outcome;Paralysed;Performance;Personal Satisfaction;Persons;Pharmaceutical Preparations;Pharmacologic Substance;Physiology;preservation;prevent;Production;protective effect;Protein Biosynthesis;protein expression;Quality of life;Reactive Oxygen Species;Regulation;Research;Role;Sampling;Sarcolemma;Skeletal Muscle;skeletal muscle metabolism;Soleus Muscle;Spinal Cord Contusions;Spinal cord injury;System;Testing;Therapeutic;tibialis anterior muscle;Time;Transgenic Mice;Transgenic Organisms;Veterans;Walking

PROJECT_TITLE: Mechanisms and treatments of mitochondrial dysfunction in paralyzed skeletal muscle after spinal cord injury

STUDY_SECTION_NAME: Career Development Program - Panel I[RRD8]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Climate-Related Exposures and Conditions

ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: Project Narrative Methane is a potent greenhouse gas that contributes significantly to global climate change, and strategies to curb atmospheric methane emissions are vital to mitigate its harmful impacts on human health. Archaea are the primary source and sink for methane in the environment, and cytochrome c proteins play an important role in methane metabolism across diverse archaeal species. Thus, investigating the molecular function of cytochrome c in the methane-metabolizing archaea will provide molecular insights into the mechanisms of methane production and consumption, which can then be used in the development of technologies to curb methane emissions.

PI_NAMEs: GUPTA, DINESH  (contact)

PROGRAM_OFFICER_NAME: JONES, LATAISIA CHERIE

PROJECT_TERMS: Anaerobic Bacteria;Archaea;Atmosphere;Binding;Biochemical;biochemical tools;Biogenesis;Biological Models;Biotechnology;citrate carrier;climate change;climate crisis;Coculture Techniques;cofactor;Complex;Consumption;Coupled;CRISPR/Cas technology;cytochrome c;Development;Electron Transport;Electrons;Engineering;Environment;Escherichia coli;Evaluation;Ferredoxin;Gene Expression;Genes;Genetic;Genetic Models;Genome;genome editing;Genomics;Goals;greenhouse gases;Growth;Health;Heme;Human;improved;In Vitro;in vivo evaluation;insight;interest;Knowledge;Mediating;Membrane;Metabolic;Methane;Methane Metabolism Pathway;Methanobacteria;methanophenazine;Methanosarcina;Methanosarcina barkeri;microorganism;Modeling;Molecular;NADH;Nature;Nitrogen Fixation;Operon;Organism;oxidation;Oxidation-Reduction;Pathway interactions;Physiological;Play;Postdoctoral Fellow;Process;Production;Proteins;Reaction;reconstitution;Research;Rhodobacter;Role;sodium ion;Source;success;sulfate reducing bacteria;Symbiosis;System;Techniques;technology development;tool

PROJECT_TITLE: Developing Methanosarcina spp. as a model system to study cytochromes c and their role in archaeal methane metabolism

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-Q(20)L]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: AMHERST

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

PHR: Project Narrative Restoring binocular vision and responsiveness to complex, naturalistic stimuli in subjects afflicted with amblyopia is a recognized challenge. By delineating the developmental trajectory of complex scene processing and identifying the circuit basis for the encoding of natural scenes, our work will ultimately lead to improved treatments for vision disorders.

PI_NAMEs: KUHLMAN, SANDRA J (contact)

PROGRAM_OFFICER_NAME: CLAYTON, EDWIN C

PROJECT_TITLE: Development and plasticity of stimulus processing in the visual cortex