NIH_SPENDING_CATS: Brain Disorders;Down Syndrome;Genetics;Intellectual and Developmental Disabilities (IDD)

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE. This project will test the transformative hypothesis that dysregulated DNA rereplication in response to cellular stress contributes to the development of Trisomy 21 (T21) and subsequent pathophysiology of Down syndrome (DS). This project arises from the observation the interferon receptor cluster encoded on chromosome 21 undergoes DNA rereplication and targeted transient site-specific gene amplification in response to viral infection in healthy cells; however, this process is impaired in T21 cells. To test our hypothesis, we will employ a combination of human and mouse culture models and a mouse in vitro fertilization model to define the extent of DNA rereplication dysregulation in T21 and how DNA rereplication could contribute to the development of T21 and comorbidities associated with DS.

PI_NAMEs: BLACK, JOSHUA CRANSTON (contact);SULLIVAN, KELLY D.

PROGRAM_OFFICER_NAME: SINGLETON, KENTNER L

PROJECT_TERMS: Address;Affect;Alzheimer's Disease;Area;Autoimmune;Automobile Driving;biological adaptation to stress;Biological Models;Biology;Black race;Body System;Celiac Disease;Cell Culture Techniques;Cell Line;Cell model;Cells;Cellular Stress;Chromatin Structure;Chromosome 21;chromosome missegregation;chromosome replication;Clustered Regularly Interspaced Short Palindromic Repeats;comorbidity;Development;Disease;DNA;Down's Syndrome;Elements;Epigenetic Process;Event;experience;extrachromosomal DNA;Fertilization in Vitro;Functional disorder;Gene Amplification;Gene Targeting;Genetic;Germ Cells;Heavy Metals;Homeostasis;Human;Human Cell Line;Hypoxia;Immune;immune activation;Immune signaling;Impairment;Individual;Inflammatory;Interferon Receptor;Interferons;leukemia;Mediating;Metal exposure;Modeling;Molecular;mouse model;Mus;novel;Oxidation-Reduction;Oxidative Stress;pathogen;Pathway interactions;Process;programs;Proteins;Receptor Gene;Regulation;response;Role;Site;Stress;Technology;Testing;Time;Viral;Virus Diseases;Work

PROJECT_TITLE: Defining the Role of DNA Rereplication of Chromosome 21 in the Development and Pathophysiology of Down Syndrome

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-L(51)R]


ADMINISTERING_IC: DK

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Cancer;Chronic Liver Disease and Cirrhosis;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Liver Cancer;Liver Disease;Prevention;Rare Diseases;Social Determinants of Health

ORG_CITY: SAN FRANCISCO

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PUBLIC HEALTH RELEVANCE Liver cirrhosis is a serious chronic condition that leads to liver cancer and death. Prevention of complications of cirrhosis is key as once complications arise, the only medically viable option for improved survival is liver transplantation. The mechanisms of disease progression, clinical risks, and therapies to prevent progression are important to reducing cirrhosis burden. The Liver Cirrhosis Network and its proposed studies will enhance understanding of strategies important to prevention of cirrhosis progression including the utility of a commonly prescribed lipid lowering medication, statin, that if beneficial will translate into improved patient care and reduction of the cirrhosis disease complication burden.

PI_NAMEs: HAMEED, BILAL ;KHALILI, MANDANA  (contact)

PROGRAM_OFFICER_NAME: DOO, EDWARD

PROJECT_TERMS: Address;adverse outcome;Anti-Inflammatory Agents;Antiinflammatory Effect;barrier to care;Biological Markers;Biological Specimen Banks;California;cancer risk;Cause of Death;Cessation of life;Cholesterol;Chronic;chronic liver disease;chronic liver injury;Chronic viral hepatitis;Cirrhosis;Clinical;clinical efficacy;Clinical Research;clinical risk;Clinical Trials;clinically significant;cohort;Communities;comorbidity;Compensation;Complication;Conduct Clinical Trials;Country;Data;Diagnostic;Disease;Disease Progression;Disparity;double-blind placebo controlled trial;Double-blind trial;efficacy testing;end stage liver disease;epidemiology study;Epithelium;ethnic minority;Etiology;Evaluation;Failure;fatty liver disease;fibrogenesis;Fibrosis;genetic signature;Genetic Variation;Goals;Health;health care availability;Hepatic;Hepatic Stellate Cell;high risk;HIV Infections;Image;improved;Individual;Injury;Intervention;Knowledge;Link;Lipids;Liver;liver biopsy;Liver Cirrhosis;Liver diseases;Liver Failure;Liver Fibrosis;liver injury;liver transplantation;Longitudinal cohort;low socioeconomic status;Malignant neoplasm of liver;Measurement;Measures;Medical;Monitor;Morbidity - disease rate;mortality;Myofibroblast;non-alcoholic;novel;Obesity;Observational Study;Organ;Outcome;oxidized low density lipoprotein;Pathogenesis;Pathway interactions;Patient Care;Patients;Pharmaceutical Preparations;Placebos;Population;Population Heterogeneity;Populations at Risk;Portal Hypertension;Prevalence;prevent;Prevention;Prevention strategy;Preventive measure;Primary carcinoma of the liver cells;problem drinker;Process;prognostic;prospective;Proteins;public health relevance;Quality of life;racial minority;Randomized;Randomized, Controlled Trials;response;Risk;Risk Factors;Role;rosuvastatin;Safety;safety testing;San Francisco;screening;Serology;Signal Pathway;Signal Transduction;Site;social health determinants;Substance Use Disorder;Testing;Therapeutic;Tissues;Transcription Coactivator;Transcriptional Coactivator with PDZ-Binding Motif;Translating;Translational Research;United States;United States National Institutes of Health;Universities;Venous Pressure level

PROJECT_TITLE: Liver Cirrhosis Network: Longitudinal and Clinical Trial Studies


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

ORG_CITY: PHILADELPHIA

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative Genetic variation is now understood to contribute to complex disease through disruption of gene regulatory networks. However, our limited understanding of the nature of these networks makes it difficult to find mechanistic links between the genome and disease. In this proposal we will combine perturbation-response data with sophisticated causal inference algorithms to build large-scale networks integrating gene expression with complex traits, enabling improved understanding of the mechanisms underlying disease.

PI_NAMEs: BROWN, BRIELIN  (contact)

PROGRAM_OFFICER_NAME: GILCHRIST, DANIEL A

PROJECT_TERMS: Algorithms;Award;biobank;Biological;Biological Markers;Biology;Blood;causal model;causal variant;cell immortalization;Cell Line;Cell model;Cell Physiology;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;comparative;Complex;Complex Genetic Trait;Computer Analysis;Computing Methodologies;CRISPR screen;CRISPR/Cas technology;Data;Data Set;denoising;design;Development;Disease;Disease Pathway;Distal;Enhancers;Etiology;Factor Analysis;Future;Gene Expression;Gene Expression Regulation;gene network;gene regulatory network;Generations;Genes;Genetic;Genetic Structures;genetic variant;Genetic Variation;Genome;genome wide association study;genome wide screen;genome-wide;genomic data;Genomics;Goals;Graph;Heritability;Human;human tissue;Immune;improved;In Vitro;Individual;Inflammatory;insight;K-562;K562 Cells;Knowledge;large scale data;Lead;learning strategy;Link;Mediating;Methods;Modality;Modeling;Molecular;Molecular Profiling;multimodal data;Multiomic Data;Nature;network models;novel;novel strategies;Nucleic Acid Regulatory Sequences;Pathway interactions;Phase;Population;Privatization;promoter;Quantitative Trait Loci;Regulatory Element;response;Role;Sampling;Signal Transduction;statistics;Structure;System;Systems Biology;targeted treatment;trait;Transcript;transcription factor;transcriptome sequencing;Work

PROJECT_TITLE: Perturbation-response approaches to determining the regulatory networks underlying human complex traits

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: SAINT LOUIS

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Stroke remains a common cause of death and disability worldwide. Neutrophils are circulating white blood cells that mediate many aspects of stroke. We will study whether targeting platelet-mediated neutrophil extracellular trap formation reduces neurological damage from stroke, and improves outcomes.

PI_NAMEs: CAMPBELL, ROBERT A (contact)

PROGRAM_OFFICER_NAME: WARREN, RONALD Q

PROJECT_TERMS: 3-Dimensional;Acute;acute stroke;adverse outcome;Affect;Animals;antimicrobial;Aspirin;Binding;Biological Assay;Blood Platelets;Blood Vessels;Brain;Brain Infarction;Brain Ischemia;brain tissue;Cause of Death;Cerebrovascular Circulation;Chromatin;circulating biomarkers;Clinical;cognitive disability;cognitive function;Data;Development;disability;Event;experience;extracellular;Feedback;Female;fighting;Genetic;HMGB1 gene;Human;Impairment;improved;improved outcome;In Vitro;in vivo;Infarction;Infection;Inflammation;Inflammatory;inhibitor;Injury;innovation;Ischemia;Ischemic Stroke;Leukocytes;Location;long term recovery;Longitudinal Studies;male;Mediating;Microbe;microbicide;Middle Cerebral Artery Occlusion;Modeling;Molecular;mortality;Motor;Mus;Nervous System Physiology;Nervous System Trauma;Neurologic;Neurologic Deficit;Neurological outcome;neutrophil;Neutrophil Activation;Neutrophil Infiltration;novel;novel therapeutics;Outcome;pathogen;Pathologic;Patients;Pattern;Persons;pharmacologic;physically handicapped;Plasminogen;Platelet Activation;Play;post stroke;Public Health;Reaction;Recovery;recruit;response;Role;scaffold;Site;Stroke;stroke model;stroke outcome;stroke patient;stroke therapy;System;Techniques;Testing;Therapeutic;Thrombectomy;thrombolysis;Thrombosis;thrombotic;thrombotic complications;Thrombus;Tissues;Venous Thrombosis

PROJECT_TITLE: Platelet-Mediated Neutrophil Extracellular Traps Regulate Ischemic Stroke Injury

STUDY_SECTION: HTBT

STUDY_SECTION_NAME: Hemostasis, Thrombosis, Blood Cells and Transfusion Study Section[HTBT]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Firearms Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Physical Injury - Accidents and Adverse Effects;Prevention;Social Determinants of Health;Violence Research

ORG_CITY: CHICAGO

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: Project Narrative: Hospital-Based Violence Intervention Programs (HVIPs) affiliated with trauma centers in the US focus on individual behavior modification for a reduction in re-victimization. There is a lack of reproducible evidence that has demonstrated effectiveness, given the exclusion of addressing inequities in the Social and Structural Determinants of Health (SSDOH), often the root cause of violent injury and preventable homicide. We propose the creation of a novel Medical-Legal Trauma Partnership to offer legal support to improve the SSDOH, reduce stress, improve the health-related quality of life in patients, families and HVIP providers alike while collaborating with the CLIF-VP Coordinating Center for broad trauma center distribution for public health impact.

PI_NAMEs: TUNG, ELIZABETH LUNJUN;ZAKRISON, TANYA L (contact)

PROGRAM_OFFICER_NAME: GILBERT, LEAH KAYE

PROJECT_TERMS: acceptability and feasibility;Address;Adoption;Affect;American College of Surgeons;Behavior Therapy;black patient;burnout;Caring;Chicago;Clinical;Collaborations;Communities;community advisory board;Complex;Consultations;Country;Data;data handling;demographics;Development;Education;Effectiveness;Employment;Equipment and supply inventories;Equity;evidence base;Exclusion;Family;Financial Support;Firearms;Future;Geographic Factor;Gun injury;gun violence;Gunshot wound;Health;health related quality of life;Homicide;Hospitals;Housing;implementation outcomes;improved;Income;Individual;Inequality;Inequity;Injury;injury prevention;Intervention;intervention program;Interview;Legal;Legal Status;Link;Measurement;Measures;Medical;member;Mental Health;Methodology;Modeling;Moral injury;Nature;novel;Outcome;Patient Self-Report;Patients;Perception;Phase;physical conditioning;Population;Pragmatic clinical trial;Prevention;Prevention program;Process;programs;Proliferating;prospective;Provider;Public Health;recidivism;Recommendation;Recovery;Reproducibility;revictimization;Sampling;screening;Side;social;social determinants;social health determinants;sociodemographic factors;Specialist;standard of care;Standardization;Stress;stress reduction;structural determinants;structural health determinants;success;Surveys;theories;Time;Trauma;trauma centers;Trauma patient;treatment as usual;Violence;violence prevention;Violent injury;Vulnerable Populations;Work

PROJECT_TITLE: Harmonizing Hospital-Based Violence Intervention Programs with a Novel Medical-Legal Partnership for Equity in the Social and Structural Determinants of Health – the HVIP-MLP Model

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CCHI-B(50)]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Chronic Pain;Clinical Research;Mental Health;Neurosciences;Pain Research;Substance Misuse

ORG_CITY: NEW HAVEN

ORG_DEPT: PSYCHIATRY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE  The proposed research and career development plans seek to investigate maladaptive avoidance learning as the principal mechanism of alcohol use disorders (AUD), a condition suffered by 15 million adults in the United States alone. Avoidance learning is complex, involving multiple neural, physiological, behavioral, and psychological processes, and currently under-explored as a pathophysiological pathway to AUD. The study proposes to directly examine these processes and identify the risk factors for the maintenance and relapse of AUD, thus potentially offering implications for the diagnosis, treatment, and ultimately the prevention of alcoholism.

PI_NAMEs: LE, THANG MANH (contact)

PROGRAM_OFFICER_NAME: EGLI, MARK

PROJECT_TERMS: addiction;Address;Admission activity;Adult;Affective;Aftercare;Alcohol abuse;alcohol abuse therapy;alcohol consequences;Alcohol consumption;alcohol craving;Alcohol dependence;alcohol relapse;alcohol seeking behavior;alcohol use disorder;alcoholism prevention;Alcohols;Analgesics;Anti-Anxiety Agents;Arousal;Avoidance Learning;Bayesian Modeling;Behavioral;behavioral impairment;Biological;biomarker identification;Brain;brain dysfunction;career;career development;Cessation of life;Characteristics;Chronic;chronic alcohol ingestion;Classification;Clinical;Clinical assessments;cognitive control;cognitive neuroscience;Complex;connectome based predictive modeling;Consumption;coping;Coping Behavior;Coping Skills;Cues;Data;Development;Development Plans;Diagnosis;Diagnostic;diagnostic accuracy;Dimensions;Distress;drinking;Emotional;Environment;Esthesia;Etiology;follow-up;Functional disorder;Functional Magnetic Resonance Imaging;Goals;Heavy Drinking;Image;improved;Individual;individualized medicine;innovation;Inpatients;Intervention;Investigation;Learning;Link;Machine Learning;Maintenance;maladaptive behavior;Medial;meetings;Mentors;midbrain central gray substance;Modeling;Motivation;Negative Reinforcements;neural;Neurobiology;neuroimaging;Neurosciences;Neurosciences Research;novel;Outcome;Pain;Pain management;Participant;Pathway interactions;Patients;Performance;Phase;Physiological;Play;Prediction of Response to Therapy;Prefrontal Cortex;problem drinker;Process;Property;psychologic;Psychophysiology;Publishing;Punishment;recruit;Relapse;relapse patients;relapse prediction;Reporting;Research;research and development;Research Personnel;Resources;response;Rewards;Risk Factors;Role;Severities;Shock;social;social deficits;Statistical Algorithm;Structure;substance abuse treatment;Techniques;Time;Training;Treatment outcome;treatment program;United States;Universities

PROJECT_TITLE: Avoidance learning and pain circuit dysfunction in alcohol use disorders


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

ORG_CITY: LAWRENCE

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF KANSAS LAWRENCE

ORG_STATE: KS

PHR: Congenital Disorders of Glycosylation (CDGs) are rare diseases of glycosylation pathways with few therapeutic options. CDGs can cause developmental delay, seizures, or early death. This research will better define the mechanisms of these diseases and identify potential therapeutics using disease modelling, genetic perturbation, and a repurposed drug screen.

PI_NAMEs: DALTON, HANS MARTIN (contact)

PROGRAM_OFFICER_NAME: BARDHAN, SUJATA

PROJECT_TERMS: Advisory Committees;Affect;Apoptosis;Biological;Biological Assay;Candidate Disease Gene;career;Cell Culture Techniques;Cell Line;Cell model;Cell Proliferation;Cells;Cellular Metabolic Process;Cessation of life;Clinical Trials;common symptom;Congenital disorders of glycosylation;Defect;Development;Developmental Delay Disorders;developmental disease;Disease;disease model;disease phenotype;Down-Regulation;Drosophila genus;drug repurposing;Drug Screening;drug use screening;endoplasmic reticulum stress;Ensure;Enzymes;Epilepsy;Eye;Faculty;fly;Future;Gene Expression;Genes;Genetic;genetic manipulation;Glycobiology;glycosylation;Goals;Health;Human;Human Cell Line;improved;In Vitro;in vivo;in vivo Model;Inborn Errors of Metabolism;Individual;Institution;Intervention;Learning;Link;loss of function;loss of function mutation;Mass Spectrum Analysis;member;Mentors;Mentorship;Metabolism;metabolomics;Microscopy;Modeling;Molecular;Molecular Biology;Mutation;new therapeutic target;novel therapeutics;Organism;Pathway interactions;patient population;Patients;Pharmaceutical Preparations;Pre-Clinical Model;Process;Proliferating;protein expression;Proteins;Rare Diseases;reduce symptoms;Research;RNA Interference;Seizures;small molecule;small molecule libraries;Stress;sugar;Techniques;Testing;Therapeutic;therapeutic evaluation;Therapeutic Uses;tool;Training;Translating;Universities;Utah;Work;Writing;Yeasts

PROJECT_TITLE: Identifying New Therapeutics and Molecular Mechanisms in Congenital Disorders of Glycosylation.


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Bioengineering;Diabetes;Kidney Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: GAINESVILLE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Limited treatment options for diabetic nephropathy, the most common cause of end-stage renal disease, urge the development of novel therapeutics for the currently incurable disease. The work will generate novel artificial intelligence (AI) methods for drug discovery and will yield potential heparanase inhibitors for the prevention and treatment of diabetic nephropathy.

PI_NAMEs: CUI, LINA  (contact);LI, CHENGLONG

PROGRAM_OFFICER_NAME: NIHALANI, DEEPAK

PROJECT_TERMS: Affect;Albuminuria;analog;Animal Model;Artificial Intelligence;artificial intelligence method;artificial intelligence model;Beta-glucuronidase;Binding;Binding Proteins;Biological;Biological Assay;Biological Availability;Cells;Chemical Structure;Clinical Trials;Coagulation Process;deep learning model;Development;diabetes management;Diabetes Mellitus;diabetic;Diabetic Nephropathy;Disease;drug discovery;Drug Kinetics;End stage renal failure;Enzymes;Evaluation;experimental study;Extracellular Matrix;Failure;Feedback;Functional disorder;Funding;Future;glomerular basement membrane;glomerular filtration;Glomerular Filtration Rate;Heparan Sulfate Proteoglycan;heparanase;Heparanase inhibitors;Heparitin Sulfate;high throughput screening;Human;Hypertension;improved;in vitro testing;Inflammatory Response;inhibitor;innovation;Insulin-Dependent Diabetes Mellitus;Investigation;Kidney Diseases;Lead;Libraries;Link;Machine Learning;machine learning model;Maximum Tolerated Dose;Methods;Modeling;Molecular;mouse model;Mus;Nature;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutics;Oral;Outcome;Patients;Pharmaceutical Preparations;Pharmacology;Phase;Play;Population;Prediabetes syndrome;Prevention;Renal function;Renin-Angiotensin-Aldosterone System;Risk;Role;screening;Side;small molecule;Structure;Symptoms;Testing;Therapeutic;Therapeutic Effect;therapeutically effective;Tissues;Training;Variant;virtual screening;Work

PROJECT_TITLE: AI-directed discovery of heparanase inhibitors

STUDY_SECTION: DMPB

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology B Study Section[DMPB]


NIH_SPENDING_CATS: Cancer;Chronic Liver Disease and Cirrhosis;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hepatitis;Hepatitis - C;Infectious Diseases;Liver Cancer;Liver Disease;Microbiome;Orphan Drug;Prevention;Rare Diseases

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE The rise in number of cirrhosis-related deaths and rates of liver cancer create an urgent need to identify better predictors of mortality in cirrhosis and develop better treatments for this disease. Here, we propose to study and monitor a group of patients with cirrhosis to better understand progression of the disease. We will also investigate whether atorvastatin is an effective treatment for cirrhosis patients.

PI_NAMEs: LOOMBA, ROHIT  (contact)

PROJECT_TERMS: Address;adjudication;Alcoholic Liver Diseases;Ancillary Study;Antineoplastic Agents;Area;Ascites;atorvastatin;California;Cardiovascular system;Cause of Death;Cessation of life;Chemopreventive Agent;Chronic Hepatitis C;Cirrhosis;Clinical;clinical infrastructure;Clinical Research;Clinical Trials Design;cohort;Cohort Studies;Compensation;Consent;County;Data;Development;Diagnosis;Disease;Disease Progression;Dose;Double-Blind Method;effective therapy;efficacy evaluation;Etiology;Event;Fibrosis;Future;General Population;Genetic Risk;genetic risk factor;gut microbiome;HCV Liver Disease;health disparity;Hemorrhage;Hepatic;Hepatic Encephalopathy;Hepatitis B Virus;Hepatitis C virus;Hepatology;Hepatorenal Syndrome;high risk;Hispanic;Hispanic Populations;HIV;Hospitalization;imaging biomarker;Institution;Intervention;lipophilicity;Liver;Liver Cirrhosis;liver stiffness;liver transplantation;Malignant neoplasm of liver;Measures;Medical;men;Meta-Analysis;microbiome;microbiome signature;Monitor;mortality;mortality risk;multi-ethnic;Multi-Institutional Clinical Trial;Natural History;non-invasive imaging;nonalcoholic steatohepatitis;Not Hispanic or Latino;novel therapeutics;Outcome;Outcome Measure;Participant;patient population;Patient Recruitments;Patients;Peritonitis;Pharmacogenetics;Phase;Placebo Control;Placebos;pleiotropism;Positioning Attribute;Prevalence;Primary carcinoma of the liver cells;primary endpoint;primary outcome;Property;prospective;Protocols documentation;randomized placebo controlled trial;Randomized, Controlled Trials;Recommendation;recruit;Research;Research Infrastructure;response;Risk;Risk Reduction;Safety;secondary outcome;Site;Testing;Time;treatment response;United States;United States National Institutes of Health;Virus Diseases;Work

PROJECT_TITLE: San Diego Cirrhosis Clinical Research Network


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Cancer;Chronic Liver Disease and Cirrhosis;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Liver Cancer;Liver Disease;Orphan Drug;Patient Safety;Prevention;Rare Diseases;Substance Misuse

ORG_CITY: NEW YORK

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: Project Narrative The proposed research is relevant to human health because patients with cirrhosis of the liver are at risk of liver disease progression, liver cancers and death, and treatments as well as the ability to identify patients at the highest risk of complications are lacking. In this application to be a clinical center in the Liver Cirrhosis Network, we propose to develop a prospective cohort to identify new ways to determine the risk of disease progression in patients with cirrhosis, and to test whether the medications pravastatin or alirocumab decrease this risk. The execution of these studies collaboratively throughout the Liver Cirrhosis Network will be crucial to understanding how patients with liver disease progress and how we can improve outcomes in this population in need.

PI_NAMEs: BROWN, ROBERT S (contact);VERNA, ELIZABETH CLARICE

PROJECT_TERMS: Alcoholic Liver Diseases;Behavior;Behavioral;Biological Markers;biomarker discovery;Cessation of life;Cholestasis;chronic liver injury;Cirrhosis;Clinical;clinical center;Clinical Data;clinical predictors;Clinical Trials;Clinical Trials Design;clinically relevant;cohort;Cohort Studies;comorbidity;Compensation;Complex;Cryptogenic cirrhosis;Data;Data Set;Development;Disease Progression;disorder risk;Effectiveness;efficacy evaluation;Electronic Health Record;Electronics;endothelial dysfunction;Etiology;Fatty acid glycerol esters;fibrogenesis;Future;Generations;Health;Hepatic;Hepatotoxicity;high risk;Human;improved;improved outcome;Incidence;Individual;Inflammation;inflammatory marker;inhibitor;innovation;insight;Intervention;Intervention Trial;Knowledge;Life;lipid metabolism;Lipids;Lipoproteins;Liver;liver allograft;Liver Cirrhosis;Liver diseases;liver transplantation;Low-Density Lipoproteins;Malignant neoplasm of liver;Measurement;Mediating;Meta-Analysis;Metabolic;Metabolism;microbiome;Morbidity - disease rate;mortality;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;novel;novel therapeutics;Outcome;Pathway interactions;Patients;Persons;Pharmaceutical Preparations;Phase;Phenotype;Placebos;Play;Population;Portal Hypertension;Pravastatin;predictive modeling;prevent;Prevention;Primary carcinoma of the liver cells;Proprotein Convertases;prospective;Prospective cohort;Prospective Studies;Prospective, cohort study;Randomized;Randomized, Controlled Trials;Reporting;Research;Resources;Retrospective Studies;Risk;Risk Factors;Role;Safety;safety study;Serum;Subtilisins;Testing;therapy outcome;Translational Research;United States;Validation;virtual;virtual world

PROJECT_TITLE: Strategies and Therapies for Outcomes Prevention in Cirrhosis: The STOP-C Liver Cirrhosis Network


ADMINISTERING_IC: LM

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Biomedical Imaging;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_DEPT: OPHTHALMOLOGY

PHR: The proposed research is relevant to public health because it involves new strategies to develop accurate and generalized computer assisted disease diagnosis models that include multi-modality data (different medical imaging modalities, free-text clinical notes and structured information), benchmark the models via multi-center external validations, and explore solutions to improve the downstream capability. The research will provide a foundation to advance ophthalmic disease diagnosis applications and a refinement

PI_NAMEs: CHEN, QINGYU  (contact)

PROGRAM_OFFICER_NAME: REDDY, GOUTHAM

PROJECT_TERMS: Computer-Assisted Diagnosis;Disease;Medical Imaging;multimodality;Natural Language Processing

PROJECT_TITLE: Natural language processing and medical imaging analysis for multi-modality computer assisted diagnosis of ophthalmic diseases


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_DEPT: CHEMISTRY

PHR: Komor – Project Narrative – “Development and Application of New Genome Editing Tools for the Functional Investigation of Genetic Variants of Uncertain Significance”  Our inability to interpret the clinical consequences of genetic variants discovered by sequencing remains a critical obstacle to the progress of precision medicine: out of the 4.6 million missense variants identified in the Genome Aggregation Database, over half are admitted to be variants of uncertain significance (VUS). New methods capable of interpreting VUS would not only enhance the efficacy of current therapies by better informing patient selection strategies, but also accelerate the development of new approaches to combat diseases with a genetic component. Here we propose the development of new genome editing tools and platforms that will allow researchers to functionally interrogate thousands of VUS individually, in combination, and in aggregate, to produce clinically-relevant information on how genetic variations cause human disease.

PI_NAMEs: KOMOR, ALEXIS C. (contact)

PROGRAM_OFFICER_NAME: MASKERI, BAISHALI

PROJECT_TERMS: Acceleration;Adenine;Admission activity;aggregation database;Area;base editing;base editor;Base Pairing;Bioinformatics;Cells;Chemicals;Chemistry;Clinical;clinically relevant;combat;Communities;CRISPR/Cas technology;Cytosine;Deamination;design;Development;Directed Molecular Evolution;Disease;DNA Double Strand Break;Enzymes;Gene Mutation;Genetic;Genetic Diseases;genetic variant;Genetic Variation;Genome;genome editing;Genomic DNA;human disease;Human Genetics;Individual;interest;Investigation;Methodology;Methods;Modification;novel strategies;nucleobase;Pathogenicity;Patient Selection;Point Mutation;precision medicine;programs;Research;Research Personnel;Single-Stranded DNA;Time;tool;Variant;variant of unknown significance;Work

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-K(55)R]


NIH_SPENDING_CATS: Aging;Chronic Liver Disease and Cirrhosis;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Infectious Diseases;Liver Disease;Microbiome;Prevention;Sarcopenia

ORG_CITY: CLEVELAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

ORG_STATE: OH

PHR: As one of the largest hospital systems nationally with a consistent referral pattern of patients with cirrhosis, we propose to be a part of the Liver Cirrhosis Network. We will establish a longitudinal cohort of cirrhotic patients with and without human immunodeficiency virus infection to enhance our mechanistic understanding of progression of disease, development of complications and predictors of clinical outcomes. We will also participate in a randomized placebo controlled trial to evaluate the benefits/safety of simvastatin in cirrhosis.

PI_NAMEs: DASARATHY, SRINIVASAN  (contact)

PROJECT_TERMS: adverse outcome;Affect;Age;Alcohol consumption;Alcoholic Liver Diseases;Alcohols;Amines;Ammonia;Angiogenesis Inhibitors;Anti-Inflammatory Agents;Antioxidants;Architecture;Ascites;biobank;Biological Markers;Cause of Death;Cessation of life;Child;chronic liver disease;Cirrhosis;Clinic;Clinical;clinical center;clinical practice;Clinical Trials;clinically significant;Cohort Studies;comorbidity;Complication;Computerized Medical Record;cost;Cross-Sectional Studies;Data;Databases;Development;Diagnosis;Diagnostic;digital applications;digital health;Disease;Disease Outcome;Disease Progression;Encephalopathies;end stage liver disease;Enrollment;Ethnic Origin;Etiology;Evaluation;Event;Fibrosis;follow-up;frailty;Functional disorder;Gender;gut microbiome;health management;Health system;Hemorrhage;Hepatic;High Prevalence;high risk;HIV;HIV Infections;Hospitals;Human;human data;Hydroxymethylglutaryl-CoA Reductase Inhibitors;Icterus;immunodeficiency;Impairment;improved;improved outcome;Infection;Injury;innovation;interest;Liver;Liver Cirrhosis;Liver diseases;Liver Fibrosis;liver inflammation;liver injury;liver transplantation;Lobular;Long-Term Care;Longitudinal cohort;Longitudinal cohort study;Longitudinal Studies;Measures;metabolomics;microbial;Modeling;mortality;Muscle;Muscular Atrophy;Myopathy;new technology;new therapeutic target;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;novel;novel marker;novel therapeutics;Organ;Outcome;participant enrollment;Pathogenesis;Patient Care;patient population;Patients;Pattern;pharmacologic;Pilot Projects;Placebos;Plasma;Play;Portal Pressure;predict clinical outcome;Prevalence;prevent;Primary carcinoma of the liver cells;primary outcome;Productivity;profiles in patients;programs;progression marker;progression risk;prospective;Prospective Studies;Prospective, cohort study;Proteomics;Public Health;Publishing;Quality of life;Randomized;randomized placebo controlled trial;randomized, clinical trials;Randomized, Controlled Trials;Reporting;research clinical testing;response;Risk;Risk Factors;Role;Safety;sarcopenia;Severities;Severity of illness;Simvastatin;Syndrome;System;Telemedicine;televisit;Testing;therapeutic target;United States;United States National Institutes of Health;Virus;Virus Diseases;young adult

PROJECT_TITLE: Prospective evaluation of outcomes in cirrhosis of different etiologies: impact of HIV infection and simvastatin therapy


ADMINISTERING_IC: AI

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: HIV/AIDS;Immunization;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PI_NAMEs: ACHARYA, PRIYAMVADA  (contact)

PROGRAM_OFFICER_NAME: MCDONALD, DAVID JOSEPH

PROJECT_TITLE: Core 1 - Structural Biology Core


ACTIVITY: ZIA

FUNDING_MECHANISM: INTRAMURAL RESEARCH

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Chronic Liver Disease and Cirrhosis;Diabetes;Digestive Diseases;Gene Therapy;Genetics;Kidney Disease;Liver Cancer;Liver Disease;Nanotechnology;Orphan Drug;Rare Diseases

ORG_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

PI_NAMEs: CHOU, JANICE  (contact)

PROJECT_TERMS: 3' Splice Site;Active Sites;Acute Renal Failure with Renal Papillary Necrosis;Adenine;adeno-associated viral vector;Age;Albumins;Animal Model;Attenuated;Autophagocytosis;Autophagosome;base editing;base editor;beta catenin;Blood;Blood Glucose;blood glucose regulation;Carcinoma;Caucasians;Childhood;Chronic Kidney Failure;Clinical;Clinical Data;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Collagen Type IV;Compensation;Complex;Complication;Cooperative Research and Development Agreement;Couples;CRISPR therapeutics;CRISPR/Cas technology;Cytoplasm;Development;Diet therapy;Disease;disease-causing mutation;Dose;Down-Regulation;ds-DNA;efficacy evaluation;Endoplasmic Reticulum;Etiology;Excretory function;Exhibits;Exons;Extracellular Matrix Proteins;Face;Family member;Fatty Liver;Fibrosis;Functional disorder;Future;gene augmentation therapy;gene correction;gene editing technology;gene therapy;Genes;Genetic Diseases;genetic technology;Genetic Transcription;Genomic DNA;genomic locus;Gluconeogenesis;Glucose;glucose production;glucose-6-phosphatase;Glucose-6-Phosphate;Glycogen;Glycogen Storage Disease Type I;Goals;Hepatic;Hepatocarcinogenesis;Heritability;Homeostasis;Human;Hydrolysis;hypercalciuria;Hypoglycemia;Impairment;in vivo;inhibitor;inorganic phosphate;Inorganic Phosphate Transporter;Integral Membrane Protein;Intestines;Kidney;Kidney Diseases;kidney fibrosis;Knock-in;Laboratories;Legal patent;Licensing;Link;lipid nanoparticle;Liver;Liver Cell Adenoma;Liver neoplasms;Mediating;Mediator;Messenger RNA;Metabolic;metabolic phenotype;Molecular;Molecular Genetics;Monitor;Mouse Strains;Mus;Mutation;Neonatal;Nonhomologous DNA End Joining;novel therapeutic intervention;novel therapeutics;Nuclear Translocation;Oligonucleotides;Outcome;overexpression;Pathogenicity;Pathologic Processes;Pathway interactions;Patients;Pharmacologic Substance;Phase;Phase III Clinical Trials;Phenotype;Phosphorylation;Physiological;preclinical study;Proteins;Proximal Kidney Tubules;Reagent;Recombinant adeno-associated virus (rAAV);renal damage;Renin;Renin-Angiotensin System;repair strategy;repaired;Risk;RNA Splicing;Seizures;Signal Transduction;SIRT1 gene;Snails;STK11 gene;System;Technology;Therapeutic;therapeutically effective;transcription factor;transgene expression;Triglycerides;Up-Regulation;urinary;Variant;vector

PROJECT_TITLE: Molecular Genetics Of Heritable Human Disorders


PI_NAMEs: OZATO, KEIKO  (contact)

PROJECT_TERMS: adaptive immunity;Adult;Alzheimer's Disease;Antigens;ATAC-seq;Autoimmune Diseases;Autophagocytosis;Binding;Binding Sites;bisulfite;Brain;Cardiovascular Diseases;Cell Lineage;cell type;Cells;Central Nervous System;Characteristics;Chromatin;Chromosome Pairing;Chronic Disease;Cleavage Under Targets and Release Using Nuclease;CpG Islands;Dendritic Cells;Development;Diabetes Mellitus;Disease associated microglia;Distant;DNA;DNA Methylation;Elements;Embryo;Enhancers;epigenome;Family;Gene Expression Regulation;Gene Silencing;Genes;Genome;genome wide association study;Histones;Host resistance;Immune system;Infection;Inflammatory;Inflammatory Response;innate immune function;insight;Interferons;Knockout Mice;Lymphoid Cell;Macrophage;Malignant Neoplasms;Mediating;Methods;methylome;Microglia;migration;monocyte;Morphology;Myelogenous;Myeloid Cells;Natural Immunity;Neuroglia;neuroinflammation;Neurons;neutrophil;pathogen;Pattern;Peripheral;Phagocytosis;Play;postnatal;Production;progenitor;programs;Reactive Oxygen Species;Regulation;Resistance;Shapes;single-cell RNA sequencing;Site;transcription factor;transcriptome;Yolk Sac

PROJECT_TITLE: Gene Regulation In The Immune System


NIH_SPENDING_CATS: Cancer;Genetics;Human Genome

PROJECT_TERMS: Acetylation;Antineoplastic Agents;Behavior;Binding;Biological Assay;Bromodomain;cancer cell;cdc Genes;Cell Cycle;Cell Cycle Progression;Cell Cycle Stage;cell growth;Cell Proliferation;cell type;Cells;Centromere;Chromatin;chromatin immunoprecipitation;Deposition;DNA Damage;Embryo;epigenetic memory;Epigenetic Process;epigenetic regulation;Exhibits;Fibroblasts;Fluorescence Recovery After Photobleaching;Gene Expression;Genes;Genetic Transcription;Genome;Growth;Heterochromatin;Histone Acetylation;Histone H3;Histone H3.3;Histones;Hour;inhibitor;insight;interest;Kinetics;Kinetochores;Knock-out;live cell imaging;Malignant Neoplasms;Mediating;Methods;Mitosis;Mus;Natural Immunity;Normal Cell;Nuclear;Nucleosomes;prevent;Proteins;Repression;response;Role;segregation;Shapes;System;Testing;Variant

PROJECT_TITLE: Chromatin and epigenetic memory


NIH_SPENDING_CATS: Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Maternal Health;Maternal Morbidity and Mortality;Nutrition;Obesity;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Women's Health Research

PI_NAMEs: GRANTZ, KATHERINE  (contact)

PROJECT_TERMS: Abdomen;Adopted;African American Women;Age;American;antenatal;Asian Women;Birth;Cesarean section;Child;Chronic Disease;Classification;Clinical;clinical care;clinical practice;clinical research site;cohort;Data;Diabetes Mellitus;dietary;Discipline of obstetrics;Disease;Endocrinology;Enrollment;epidemiology study;fetal;Fetal Growth;Fetal Growth Retardation;Fetal Monitoring;Fetal Weight;Fetus;follow-up;Gestational Age;Goals;Growth;Gynecologic;Gynecology;Health;Hispanic Women;improved;Infant;Intake;Journals;Life;Maternal and Child Health;maternal obesity;maternal risk;Methodology;Morbidity - disease rate;mortality;multi-ethnic;National Institute of Child Health and Human Development;neonatal morbidity;Neonatal Mortality;Non obese;Nutritional;Obesity;Observational epidemiology;Pattern;Pediatrics;perinatal morbidity;Perinatal mortality demographics;Physiological;Population;population health;Pre-Eclampsia;Pregnancy;Pregnancy Complications;pregnancy disorder;Pregnant Women;Printing;recruit;reproductive;Research;Research Personnel;Risk;Societies;Twin Multiple Birth;two-dimensional;Ultrasonography;United States;Urologic Diseases;Weight;White Women;Woman;Work

PROJECT_TITLE: NICHD Fetal Growth Studies


NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Nutrition;Obesity;Pediatric;Pregnancy;Racial and Ethnic Minority Health Research;Women's Health Research

PROJECT_TERMS: 3-Dimensional;Adolescence;adverse outcome;African American;Agreement;American;Anatomy;Area;arm;Asian Women;Biological Markers;Biometry;Body Composition;Body mass index;body volume;Characteristics;Childhood;Clinical Management;cohort;Collection;Data;Discipline of obstetrics;Disease;Enrollment;Ensure;Epidemiology;Ethnic Origin;Ethnic Population;Fat Body;Fatty acid glycerol esters;fetal;Fetal Growth;Fetus;Genetic;Gestational Diabetes;Goals;Gravid;Growth;Gynecology;Health;healthy pregnancy;Hispanic;Hypertension;Image;Infant;Journals;lean body mass;lifestyle factors;Limb structure;Measurement;Measures;Metabolic;Methods;National Institute of Child Health and Human Development;Not Hispanic or Latino;nutrition;Nutritional;Obesity;Organ;Organ Size;Paper;Pathologic;Pattern;Personal Satisfaction;Predisposition;Pregnancy;Pregnancy Complications;Printing;Prospective cohort;Publishing;Race;racial population;Reproducibility;Research;Research Design;Risk;Second Pregnancy Trimester;soft tissue;subcutaneous;Subcutaneous Tissue;Thick;Thigh structure;Thinness;Third Pregnancy Trimester;Training;Twin Multiple Birth;two-dimensional;Ultrasonography;ultrasound;Visceral;Weight;Weight Gain;Woman;women's outcomes;Work

PROJECT_TITLE: Fetal 3D Study


NIH_SPENDING_CATS: Aging;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Maternal Health;Pediatric;Pregnancy;Prevention;Women's Health Research

PI_NAMEs: TEKOLA-AYELE, FASIL  (contact)

PROJECT_TERMS: accelerated epigenetic aging;Adult;Aging;Cardiometabolic Disease;cardiometabolic risk;cardiometabolism;Childhood;Decidua Basalis;depressive symptoms;disease disparity;Disparity;DNA Methylation;Early Intervention;early pregnancy;Energy Metabolism;Environmental Risk Factor;Epigenetic Process;epigenome;fetal;Fetal Growth;First Pregnancy Trimester;Focus Groups;Gene Expression;Genes;Genetic;genetic epidemiology;Genetic Risk;genetic variant;Genomics;Goals;Growth;Human;late life;Life;Link;Lipids;Mental Health;Methylation;neurodevelopment;Non-Insulin-Dependent Diabetes Mellitus;novel;Outcome;Pathway interactions;Placenta;Population;Pregnancy;Pregnancy Complications;Pregnancy Outcome;prenatal;Research;Second Pregnancy Trimester;sex;Site;Small for Gestational Age Infant;Social support;transcriptome;Variant

PROJECT_TITLE: Genetic epidemiology of early growth and cardiometabolic diseases


NIH_SPENDING_CATS: Aging;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Genetics;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Women's Health Research

PI_NAMEs: YEUNG, EDWINA  (contact)

PROJECT_TERMS: adverse pregnancy outcome;Affect;African American population;age acceleration;Aging;Alabama;Anthropometry;Biological;Birth;Birth Weight;Body Composition;Cardiac health;cardiovascular risk factor;Clinical;clinical research site;cohort;Data;delivery complications;Development;Disease;epigenetic clock;Epigenetic Process;father role;fetal;Fetal Growth;Fetal Monitoring;Gene Expression;Genetic;genetic approach;genome wide association study;genomic locus;Gestational Diabetes;Goals;Health;insight;Link;Louisiana;male;Measures;Neonatal;neonatal health;neonatal morbidity;North Carolina;Pathway interactions;Pennsylvania;Perinatal mortality demographics;Placenta;Population;Pregnancy;pregnancy health;Pregnancy Outcome;Pregnant Women;Randomized;recruit;Research;Sampling;SARS-CoV-2 infection;Scanning;secondary analysis;Seminal fluid;Time;ultrasound;Utah;Variant;Virginia;Visit;Woman

PROJECT_TITLE: Study of Pregnancy And Neonatal Health (SPAN)


PROJECT_TERMS: Aging;Antioxidants;Biological Assay;Biological Markers;Child;Circulation;Data Analyses;early pregnancy;epigenetic aging;Excretory function;Fetal Growth;Goals;Health;Inflammation;Link;Monitor;National Institute of Child Health and Human Development;oxidative DNA damage;Oxidative Stress;Pathologic;Placenta;Plasma;Pregnancy;Pregnant Women;Premature aging syndrome;Signal Transduction;Strategic Planning;Testing

PROJECT_TITLE: Oxidative DNA damage markers and epigenetic aging of placenta


NIH_SPENDING_CATS: Childhood Obesity;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Nutrition;Obesity;Pediatric;Prevention;Racial and Ethnic Minority Health Research

PROJECT_TERMS: Address;Adult;African;African American;African American population;African ancestry;Age;American;Anthropometry;Barker Hypothesis;Biological;Birth;Blood specimen;Cardiometabolic Disease;Child;Childhood;Chronic;clinical translation;cohort;Communities;Data;design;Development;Disease;DNA;early childhood;early pregnancy;Enrollment;Environmental Risk Factor;Equity;Ethnic Origin;Etiology;European;European ancestry;follow-up;Follow-Up Studies;Functional disorder;Future;Genes;Genetic;Genetic Databases;genome resource;genome wide association study;genome-wide;genomic locus;Genomics;Genotype;Growth;Health;health inequalities;Healthcare;improved;Individual;infancy;Intervention;late life;Light;Link;Longitudinal cohort;Measurement;Measures;Medical center;Metabolic;Molecular;Monitor;Neonatal;Newborn Infant;non-genetic;novel;Obesity;obesity in children;offspring;Pathway interactions;Perinatal;Phenotype;Population;Pregnancy;Pregnant Women;Prenatal care;prevent;prospective;Puerto Rican;Research;risk variant;Sampling;School-Age Population;Serum;Testing;Time;trait;Umbilical Cord Blood;United States;Visit;Whole Blood;whole genome;Woman

PROJECT_TITLE: Genetics of early childhood longitudinal growth and obesity among African- and European- Americans in the Collaborative Perinatal Project


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering

ORG_CITY: NOTRE DAME

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF NOTRE DAME

ORG_STATE: IN

PHR: NARRATIVE Mechanical properties and forces the body are often modulated during disease initiation and progression. However, little is known about the response of immune cells to these mechanical cues, particularly at the tissue- length scale, and even in normal physiological settings. Establishing an omics-based understanding of functional immunological changes in response to mechanical perturbations will broaden our knowledge of “mechano- immunology” – a burgeoning subfield in basic biomedical sciences that in the near future will reveal new pathophysiological insights and targetable vulnerabilities for human disease.

PI_NAMEs: DATTA, MEENAL  (contact)

PROGRAM_OFFICER_NAME: ZHAO, XIAOLI

PROJECT_TERMS: Affect;Animal Model;Antigens;Artificial Intelligence;Behavior;Biophysics;cell behavior;Cell Communication;Cells;cellular engineering;Disease;Disease Progression;Engineering;Future;Generations;Genetically Engineered Mouse;human disease;Image;Immune;Immune response;Immunocompetent;immunogenic;Immunologics;Immunology;in vivo;Inflammatory Response;insight;Knowledge;Laboratories;Length;mechanical force;mechanical properties;mechanical signal;Mechanics;Mediating;Motility;multiphoton microscopy;National Institute of General Medical Sciences;Organ;Pathologic;Phenotype;Physiological;programs;Research;Research Personnel;response;Science;single-cell RNA sequencing;Site;System;Testing;therapy resistant;Tissues;tool;trafficking;Transgenic Organisms;Translational Research;wound

PROJECT_TITLE: Establishing an immune mechanome

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CDB-B(55)R]


FUNDING_MECHANISM: NON SBIR/STTR CONTRACTS

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Emerging Infectious Diseases;Genetics;Immunization;Infectious Diseases;Influenza;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PI_NAMEs: CROWE, JAMES E (contact)

PROJECT_TERMS: Animals;Antibodies;Antibody Response;antibody-dependent cell cytotoxicity;antibody-dependent cellular phagocytosis;Antibody-mediated protection;Antigens;B-Lymphocyte Epitopes;Binding;Biological;Biological Assay;Complement;Computer software;Contracts;Coupled;Crystallography;Data;Databases;Deposition;Deuterium;Development;Electron Microscopy;Epitope Mapping;Epitopes;Evaluation;Future;Genetic;Goals;Human;human monoclonal antibodies;Hydrogen;Immune;In Vitro;Influenza;Influenza Hemagglutinin;Mass Spectrum Analysis;Mediating;Monitor;Mutagenesis;Neuraminidase;neutrophil;Pathogenesis;Pathologic;Phagocytosis;prophylactic;Proteins;rational design;Resources;response;Sampling;Site;Structure;Support Contracts;Testing;Therapeutic;tool development;Translating;vaccine trial;Vaccines;Validation

PROJECT_TITLE: B-Cell Epitope Discovery and Mechanisms of Antibody Protection: Genetic and Structural Basis for Influenza Neutralization


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Coronaviruses;Emerging Infectious Diseases;Immunization;Infectious Diseases

PROJECT_TERMS: 2019-nCoV;Antibody-mediated protection;B-Lymphocyte Epitopes;Epitope Mapping;Human;human monoclonal antibodies;Modification;Research;Support Contracts

PROJECT_TITLE: B-CELL EPITOPE DISCOVERY AND MECHANISMS OF ANTIBODY PROTECTION: Modification for SARS-CoV2 Research


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Immunization;Infectious Diseases;Orthopoxviruses;Prevention;Rare Diseases

PROJECT_TERMS: Animal Model;Antibodies;Antibody-mediated protection;B-Lymphocyte Epitopes;Contractor;Contracts;Epitopes;extracellular;Goals;GPA33 gene;Infection;manufacture;Monkeypox;Monkeypox virus;neutralizing antibody;nonhuman primate;Poxviridae;Prevention;Prevention approach;programs;prophylactic;Proteins;public health emergency;Testing;Therapeutic;United States;Validation;Virion;Virus Diseases

PROJECT_TITLE: B-CELL EPITOPE DISCOVERY AND MECHANISMS OF ANTIBODY PROTECTION


ORG_DEPT: PATHOLOGY

PI_NAMEs: ESTERHAZY, DARIA  (contact)

PROGRAM_OFFICER_NAME: KELLY, HALONNA R

PROJECT_TERMS: Address;Allergic;allergic airway inflammation;Antigens;ATAC-seq;Autoimmune Diseases;Autoimmunity;Bioinformatics;Bone Marrow;candidate identification;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Color;CRISPR/Cas technology;cytokine;Dedications;design;Development;Enhancers;epigenetic marker;Epigenetic Process;Exposure to;Flow Cytometry;GATA3 gene;Gene Expression;Generations;Genetic;Genetic Models;genome-wide;Goals;Health;Helper-Inducer T-Lymphocyte;Homeostasis;Human;Hypersensitivity;Immune response;in vivo;Infection;insight;Instruction;Liver;Lymphocyte;Lymphoid;Maps;microbial;Modeling;mouse model;Mus;mutant;Natural Killer Cells;Nature;novel;novel strategies;pathogen;Pathway interactions;Pattern;Phase;Population;programs;Property;Reporter;Reporting;Research;Resolution;response;Role;Salivary Glands;Specificity;System;T-Lymphocyte;Th2 Cells;Thymus Gland;Tissues;tool;transcription factor;Transcriptional Regulation;transcriptome sequencing;tumor;Uterus;Virus Diseases;ZNF145 gene

PROJECT_TITLE: Transcriptional Regulation of Innate-Like T Cells


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Data Science;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

PHR: PROJECT NARRATIVE Busy hospital settings and information overload from the electronic health record (EHR) contribute to decisional shortcuts and biases by clinicians that lead to missed opportunities for timely and accurate diagnoses. The proposal aims to develop novel clinical natural language processing (NLP) models that learn and integrate multi- modal EHR data, conduct reasoning over a large-scale medical knowledge base, and test them in a clinical decision support system to mitigate diagnostic error. Completion of the aims will inform the development of NLP- driven clinical decision support tools that generate accurate diagnoses to overcome provider heuristics and improve patient outcomes.

PI_NAMEs: GAO, YANJUN  (contact)

PROJECT_TERMS: accurate diagnosis;Address;Adverse event;Affect;annotation  system;Artificial Intelligence;Artificial Intelligence enhanced;augmented intelligence;Benchmarking;Caring;Cessation of life;Clinical;clinical application;clinical care;clinical decision support;Clinical Decision Support Systems;clinical diagnostics;clinical implementation;Clinical Informatics;Clinical Research;Clinical Trials;Cognitive;cognitive load;cognitive process;Collaborations;computer scientist;computerized;Computers;computing resources;Critical Care;Critical Illness;Data;data modalities;Decision Making;Decision Support Systems;design;Development;Diagnosis;Diagnostic;diagnostic accuracy;Diagnostic Errors;Differential Diagnosis;Disease;Electronic Health Record;Engineering;Ensure;Environment;Evidence Based Medicine;experience;Fatigue;Future;Generations;generative models;Goals;Health Personnel;Health system;heuristics;hospital care;Hospitals;Human;human centered design;improved;Informatics;information organization;Information Retrieval;innovation;instrument;Intensive Care Units;Knowledge;knowledge base;Language;Learning;Medical;Medical Care Team;Medical Errors;Mentors;Mentorship;Methods;model building;model development;Modeling;multidisciplinary;multimodality;Natural Language Processing;neural;neural model;Neural Network Simulation;novel;outcome prediction;Output;patient safety;Patient-Focused Outcomes;Patients;Performance;Persons;Physicians;Pilot Projects;Process;programs;prototype;Provider;Recommendation;Research;Research Training;Science;Scientist;Source;Specialist;Speed;Structure;success;Supervision;support tools;Symptoms;System;systematic review;Testing;Text;Time;tool;Training;Unified Medical Language System;United States National Library of Medicine;Universities;Wisconsin;Work

PROJECT_TITLE: Developing and Evaluating Multi-Modal Clinical Diagnostic Reasoning Models for Automated Diagnosis Generation


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Endocrine Disruptors;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: NARRATIVE We are proposing to establish the Michigan Cancer and Research on the Environment Study (MI- CARES) which will include 100,000 participants aged 25-44 from Black, Hispanic, Middle Eastern and North African, and White racial/ethnic groups who reside in six environmental injustice hotspots in the state as there is an urgent need to fully understand the association between environmental exposures and cancer among understudied populations. We will study the impact of environmental exposures that are questionnaire-reported (e.g., personal care product use), proximity/model-based (e.g., air pollution and PFAS), and perinatal from linkage with birth records on inflammation measures (e.g., body mass index) as intermediate cancer markers in the entire cohort. We will also study laboratory-measured exposures (xenobiotics, PFAS, metals) and intermediate cancer biomarkers (cellular aging, immune function, inflammation, and metabolic pathway alteration) in a sub-cohort of cancer-free participants (n=1,000) and using a nested case- control design for those who develop cancer (n=250 cases and 250 controls).

PI_NAMEs: DOLINOY, DANA ;MUKHERJEE, BHRAMAR ;PEARCE, CELESTE LEIGH (contact)

PROGRAM_OFFICER_NAME: DELLAVALLE, CURT TAVIS

PROJECT_TERMS: Address;Adult;African race;aged;Air Pollution;Animal Feed;anti-cancer research;Area;Awareness;Behavior;Biological Aging;Biological Assay;Biological Markers;Birth Records;Black race;Blood;Body mass index;cancer biomarkers;cancer risk;carcinogenicity;Carcinogens;case control;Caucasians;Cell Aging;Chemicals;Cities;coal-fired power plant;cohort;Collection;Communication;Communities;community engagement;contaminated water;Data;Data Collection;design;Disparity;DNA Methylation;Enrollment;Environment;environment related cancer;Environmental Carcinogens;Environmental Exposure;Environmental Impact;Environmental Pollutants;epigenetic regulation;ethnic diversity;Ethnic Origin;Ethnic Population;experience;Exposure to;Faith leader;Feasibility Studies;follow-up;Garbage;Geographic Locations;Goals;Health;Health protection;Heavy Metals;Hispanic;hispanic community;immune function;Individual;Industrialization;Inflammation;Institutional Review Boards;Laboratories;Laboratory Study;Lead;lead contamination;Life Cycle Stages;Life Style;lifestyle factors;Location;Malignant Neoplasms;Measurement;Measures;Mediating;member;men;Metabolic Pathway;metabolic profile;metabolomics;Metals;metropolitan;Michigan;Middle Eastern;Modeling;Modification;Morbidity - disease rate;mortality;Nested Case-Control Study;Noise;North African;novel;Oils;Participant;Patient Self-Report;Perinatal;Perinatal Exposure;personal care products;Phase;Poly-fluoroalkyl substances;Polybrominated Biphenyls;Population;Predisposition;Private Enterprises;Procedures;Protocols documentation;Public Health;Questionnaires;Race;racial diversity;racial population;Recording of previous events;recruit;regional pollution;Reporting;Research;Risk Assessment;Safety;Saliva;Sampling;sociodemographics;Socioeconomic Status;Spottings;Steel;Testing;Toxin;Water Supply;Woman;Xenobiotics

PROJECT_TITLE: MI-CARES: The Michigan Cancer and Research on the Environment Study


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

ORG_CITY: BOCA RATON

ORG_NAME: FLORIDA ATLANTIC UNIVERSITY

PHR: NARRATIVE Substance abuse disorders including opioid dependence are characterized by an imbalance between the gen- eration and detoxification of reactive oxygen species (ROS) in the brain. In turn, ROS react with cysteine residues and these stress-related modifications often trigger changes in protein structure and function. The research pro- posed here develops and applies an innovative new chemoproteomics approach that will furnish a global portrait S-sulfenated (oxidized) cysteine ligandability in cell-based model of mu opioid receptor (MOR) signaling. The discovery of small molecules that bind to S-sulfenated (oxidized) cysteines in biological targets relevant to MOR signaling should serve as a rich resource for chemical probes and ultimately therapeutics to treat addiction and substance use disorders.

PI_NAMEs: CARROLL, KATE SUZANNE (contact)

PROGRAM_OFFICER_NAME: ANANTHAN, SUBRAMANIAM

PROJECT_TITLE: Nucleophile-Fragment Screening for Site-Specific Covalent Ligand Discovery in Opioid Receptor Signaling

STUDY_SECTION: CBP

STUDY_SECTION_NAME: Chemical Biology and Probes Study Section[CBP]


NIH_SPENDING_CATS: Cancer

ORG_CITY: HANOVER

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PI_NAMEs: GERLACH, ROBERT W (contact)

PROGRAM_OFFICER_NAME: BELIN, PRECILLA L

PROJECT_TERMS: Adopted;American Cancer Society;Applications Grants;Award;Basic Science;Budgets;Calendar;Cancer Center;Cancer Center Support Grant;Capital;career;Center Core Grants;Charge;Clinical Oncology;Clinical Trials;Collaborations;college;Communication;Communities;community engagement;Community Outreach;Data;Decision Making;Development;equipment acquisition;experience;Faculty;Faculty Recruitment;Funding;graduate school;Grant;Health system;implementation efforts;Individual;Institution;inter-institutional;Investments;Lead;Leadership;Maintenance;Malignant Neoplasms;medical schools;member;Norris Cotton Cancer Center;Oncology Group;Parents;Performance;Pilot Projects;Population Sciences;Positioning Attribute;Preparation;Principal Investigator;Process;programs;Progress Reports;recruit;Reference Document;Reporting;Research;Research Personnel;Research Project Grants;Resource Sharing;Resources;Role;Secure;Services;Specific qualifier value;Strategic Planning;System;The Jackson Laboratory;Time;Translational Research;United States National Institutes of Health;Update;Vision;web site;Work

PROJECT_TITLE: Cancer Center Administration


NIH_SPENDING_CATS: Cancer;Clinical Research;Health Services;Radiation Oncology

PI_NAMEs: BERWIN, BRENT L (contact)

PROJECT_TERMS: Address;American Cancer Society;anti-cancer research;Area;Award;Awareness;base;Businesses;cancer care;Cancer Center Support Grant;cancer therapy;career;career development;Caring;Centers of Research Excellence;Clinical;clinical practice;clinical translation;Collaborations;college;community partnership;curriculum development;Dedications;Development;disadvantaged background;Education;education resources;Educational process of instructing;Eligibility Determination;Engineering;Evaluation;experience;Exposure to;Faculty;Fostering;Foundations;Funding;Future;Generations;Goals;Grant;Health;Health system;Healthcare Systems;Honduras;improved;innovation;Institution;Joints;K-Series Research Career Programs;Knowledge;Leadership;Learning;Link;Malignant Neoplasms;Medical;Medical Residency;medical schools;Medical Students;member;Mentors;minority undergraduate;Mission;next generation;Norris Cotton Cancer Center;novel;Oncology;Operative Surgical Procedures;Physicians;Positioning Attribute;Prevention;Program Development;programs;Provider;Radiation Oncology;Radiation Physics;Reporting;Research;Research Personnel;Research Training;Residencies;Resources;Rwanda;Scholars Program;Schools;Science;Scientist;Students;teacher;Time;Training;Training and Education;Training Programs;translational medicine;translational oncology;translational physician;Translational Research;undergraduate student;Underrepresented Minority;United States National Institutes of Health;Vision;Writing

PROJECT_TITLE: Cancer Research Career Enhancement


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Data Science;Networking and Information Technology R&D (NITRD)

PI_NAMEs: TOSTESON, TOR D (contact)

PROJECT_TERMS: Administrative Efficiency;anti-cancer research;Applications Grants;Award;Behavioral Research;Bioinformatics;bioinformatics resource;Bioinformatics Shared Resource;biomedical data science;Biometry;Biotechnology;Budgets;Cancer Biology;Cancer Center Support Grant;Cancer Detection;Client;Clinic;Clinical Cancer Center;Clinical Protocols;Clinical Research;Clinical Trials Design;Collaborations;Comparative Effectiveness Research;computer cluster;Computer software;Computer Systems;Consult;Consultations;Data;Data Analyses;data management;data mining;Databases;design;Development;Education;Engineering;experience;Faculty;Funding;Gene set enrichment analysis;Genetic;genomic data;Genomics;Goals;High Performance Computing;Home;image processing;Individual;Information Systems;Institution;Machine Learning;Malignant Neoplasms;Manuscripts;medical specialties;member;Mentors;Methodology;Monitor;Norris Cotton Cancer Center;novel;parallel computer;Pathway Analysis;Pathway interactions;Pediatrics;Peer Review;Population Sciences;programs;protocol development;Protocols documentation;Publications;Quality of life;Randomized;Reporting;Research Design;Research Personnel;Research Proposals;Research Support;Resource Informatics;Resource Sharing;Resources;response;Safety;Sample Size;Science;Services;Site;sound;Statistical Methods;Statistical Study;Terminal Disease;Therapeutic;Time;tool;Translational Research;United States National Institutes of Health;Walking

PROJECT_TITLE: Biostatistics and Bioinformatics (BBSR)


PI_NAMEs: LEWIS, LIONEL DAVID (contact)

PROJECT_TERMS: Biological Assay;Budgets;Cancer Center Support Grant;Cells;Clinical;Clinical Cancer Center;Clinical Oncology;Clinical Pharmacology;Clinical Research;clinical translation;Concentration measurement;Consultations;cost;Data Analyses;data modeling;design;detection method;Development;DNA;Drug Combinations;Drug Kinetics;Epidemiology;epidemiology study;Faculty;Fluorescence;Funding;High Pressure Liquid Chromatography;in vivo;Investigation;Investigational Drugs;Investigational New Drug Application;Investigational Therapies;liquid chromatography mass spectrometry;Malignant Neoplasms;member;Molecular;Norris Cotton Cancer Center;novel;Oncology;operation;Performance;Peripheral Blood Mononuclear Cell;Pharmaceutical Preparations;Pharmaceutical Services;Pharmacists;pharmacodynamic model;Pharmacodynamics;pharmacokinetics and pharmacodynamics;pharmacologic;Pharmacology;Pharmacology Shared Resource;Pharmacy facility;Phase;Plasma;pre-clinical;Pre-Clinical Model;preclinical study;programs;Protocols documentation;Research;Research Assistant;Research Design;Research Methodology;Research Personnel;Saliva;Sampling;Services;Site;Testing;Therapeutic;Therapeutic Studies;Translations;Tumor Tissue;ultraviolet;Urine

PROJECT_TITLE: Clinical Pharmacology (CP)


PI_NAMEs: TOMLINSON, CRAIG R (contact)

PROJECT_TERMS: 3-Dimensional;absorption;Antigens;ATAC-seq;Bar Codes;Bioinformatics;Bioinformatics Shared Resource;Biological Assay;Biology;Biomedical Research;Biometry;Budgets;Cancer Center;Cancer Center Support Grant;Cell Culture Techniques;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Chromium;CLIA certified;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;college;Communication;Communities;Complement;congenic;Core Facility;cost effective;cost effective measures;Data;Data Analyses;design;Detection;Dideoxy Chain Termination DNA Sequencing;digital;DNA;DNA Sequence;DNA Sequence Alteration;DNA sequencing;Ensure;epigenomic profiling;exome;experience;experimental study;Fee-for-Service Plans;Funding;Future;Gene Expression Profiling;Genome;genome-wide;Genome-wide Unbiased Identification of DSBs Enabled by sequencing;genomic data;Genomics;Genotype;Human Resources;improved;Institution;instrument;instrumentation;Investigation;Investments;Knock-in;Knock-out;Laboratories;laboratory experience;Leadership;Marketing;Measurement;member;Messenger RNA;Methodology;Microarray Analysis;MicroRNAs;Mission;Molecular Biology;Molecular Biology Shared Resource;Monitor;Mus;nano-string;new technology;Norris Cotton Cancer Center;Pathology;Patient-Focused Outcomes;Performance;Pilot Projects;prevent;Procedures;programs;Protein Analysis;protein profiling;Proteins;Proteomics;Protocols documentation;Quality Control;Radar;Reagent;recruit;Reproducibility;Research;research facility;Research Personnel;Resource Sharing;Resources;RNA;Running;Sampling;service providers;Services;single cell genomics;single cell sequencing;SNP genotyping;Speed;success;symposium;System;targeted sequencing;Technology;technology development;Time;tool;transcriptome;transcriptome sequencing;translational impact;translational medicine;whole genome;Work

PROJECT_TITLE: Genomic and Molecular Biology (GMB)


NIH_SPENDING_CATS: Cancer;Immunotherapy

PI_NAMEs: CHANNON SMITH, JACQUELINE YVONNE (contact)

PROJECT_TERMS: analysis pipeline;B-Lymphocytes;Biological Assay;Biotechnology;Blood;Budgets;Cancer Center Support Grant;cancer clinical trial;cancer immunotherapy;Cell Separation;Cells;chimeric antigen receptor T cells;Client;Clinical Trials;Collaborations;college;Color;Communities;Conduct Clinical Trials;Consent;Consultations;Cryopreservation;cytokine;Cytometry;Data;Data Analyses;design;Development;Equipment;Excision;Experimental Designs;extracellular;Flow Cytometry;Flow Cytometry Shared Resource;Fluorescence;Frequencies;Funding;Genus Hippocampus;Grant;Guidelines;Human;Immune;Immune checkpoint inhibitor;Immune system;Immunoassay;Immunologic Monitoring;Immunologics;Immunology;improved;Individual;instrument;Laboratories;laboratory experience;Lasers;Leukocytes;Maintenance;Malignant Neoplasms;Measurement;Measures;Melanoma;member;metabolic abnormality assessment;Mission;monocyte;Mus;NCI Center for Cancer Research;Norris Cotton Cancer Center;novel strategies;novel therapeutics;Operative Surgical Procedures;Patients;Peer Review;Performance;Peripheral Blood Mononuclear Cell;Phenotype;programs;Publications;Reader;Recommendation;recruit;repository;Research;Research Personnel;Resource Sharing;Running;Scientist;Services;skills;Skin;Specimen Handling;Stains;Students;success;T-Lymphocyte;Technology;Testing;Time;tissue resident memory T cell;Tissues;TNFRSF5 gene;TNFSF5 gene;Training;Translational Research;Venous blood sampling;Whole Blood

PROJECT_TITLE: Immune Monitoring and Flow Cytometry (IMFC)


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Cancer;Radiation Oncology;Rare Diseases

PI_NAMEs: HOOPES, JACK  (contact)

PROJECT_TERMS: anatomic imaging;angiogenesis;Angiography;animal imaging;Animals;anti-cancer research;Bioluminescence;biomedical imaging;Biotechnology;Brain Neoplasms;Budgets;Cancer Center;Cancer Center Support Grant;cancer surgery;cancer therapy;Cells;cellular imaging;Clinical Research;clinical translation;Communities;Complex;cost effective;Data Analyses;Dedications;Development;Diagnosis;Diagnostic Imaging;dosimetry;driving force;Electron Microscopy;Environment;Equipment;experience;Experimental Designs;Family suidae;Fluorescence Microscopy;Fluoroscopy;Frequencies;Functional Magnetic Resonance Imaging;Funding;Genetic;Head and Neck Cancer;Histopathology;Human;Image;Image Analysis;image visualization;imager;imaging agent;imaging modality;Imaging Techniques;improved;Inflammation;innovation;Institution;instrumentation;irradiation;live cell imaging;Magnetic Resonance Imaging;Maintenance;Malignant Neoplasms;member;Membrane Protein Traffic;Methods;microscopic imaging;Microscopy;Microvascular Permeability;Modality;Modeling;Molecular;Molecular Genetics;Molecular Target;multimodality;NCI Center for Cancer Research;Nerve;new technology;next generation;Norris Cotton Cancer Center;novel;Operative Surgical Procedures;Optics;Pharmacologic Substance;Positron-Emission Tomography;pre-clinical;preclinical imaging;Productivity;programs;Qualifying;Radiation Oncology;radiological imaging;Research;Research Peer Review;Research Personnel;Research Project Grants;Resource Sharing;Resources;Rodent;Scanning Electron Microscopy;Services;Techniques;Technology;Therapeutic;Time;Tissues;tool;Transmission Electron Microscopy;tumor;ultrasound;Update;Whole Organism;Workplace;Xenograft procedure

PROJECT_TITLE: Irradiation, Preclinical Imaging, & Microscopy (IPIM)


NIH_SPENDING_CATS: Breast Cancer;Cancer;Genetics;Women's Health Research

PI_NAMEs: FIERING, STEVEN  (contact)

PROJECT_TERMS: Alleles;Antibodies;Area;Award;Biology;Biomedical Research;Breast Adenocarcinoma;Breast Cancer Model;Budgets;Cancer Center;Cancer Center Support Grant;Communicable Diseases;Communities;Complex;cost effective;CRISPR/Cas technology;embryonic stem cell;Engineering;Experimental Designs;Experimental Models;experimental study;Faculty;flexibility;Funding;Gene Modified;Generations;Genes;Genetic;Genetically Engineered Mouse;Glioma;Human;Human Resources;ID2 gene;Knock-in;LoxP-flanked allele;Maintenance;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Neoplasms;member;model organism;Modeling;Modification;mouse model;Mus;NCI Center for Cancer Research;Neurosciences;Norris Cotton Cancer Center;Nursing Faculty;Pathologic;Phosphotransferases;programs;Reporting;Research;Research Personnel;Resource Sharing;Resources;Role;Schools;Services;skills;Solvents;Technology;Time;tissue culture;Update;Work;zygote

PROJECT_TITLE: Mouse Modeling (MM)


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Hematology;Human Genome;Orphan Drug;Precision Medicine;Rare Diseases

PI_NAMEs: TSONGALIS, GREGORY JAMES (contact)

PROJECT_TERMS: Accreditation;Acute Myelocytic Leukemia;Adult;biobank;Biological Assay;Biological Markers;biomarker development;biomarker discovery;Budgets;Cancer Center Support Grant;cell free DNA;Cell Therapy;Childhood;CLIA certified;Clinical;Clinical Data;Clinical Trials;Computer software;Data;data mining;data warehouse;Databases;design;Environment;Funding;fusion gene;Gastrointestinal Stromal Tumors;Gene Mutation;gene panel;gene therapy;Genes;genomic data;Genomics;Glioma;Histology;Human;Immunofluorescence Immunologic;Institution;Ions;Laboratories;Malignant Neoplasms;Medicine;member;metastatic colorectal;Metastatic Melanoma;multidisciplinary;Mutation;Myelogenous;next generation sequencing;Non-Small-Cell Lung Carcinoma;Norris Cotton Cancer Center;Oncogenes;Pathology;Patients;personalized medicine;Physicians;programs;Publications;Research;research clinical testing;Research Personnel;Resource Sharing;Role;Sampling;Sarcoma;Scientist;Services;Solid Neoplasm;Somatic Mutation;Specimen;System;targeted treatment;Technology;Testing;Translational Research;triple-negative invasive breast carcinoma;tumor

PROJECT_TITLE: Pathology (PSR)


PI_NAMEs: JACKSON, BRIAN P (contact)

PROJECT_TERMS: analytical method;Animal Organ;animal tissue;Arsenic;Beverages;bioimaging;Biological;Blood;Budgets;Cancer Center;Cancer Center Support Grant;Carcinogens;case-by-case basis;Catchment Area;Cells;Cereals;Chemicals;Chromatography;Coupled;Data;early life exposure;Elements;Ensure;Exposure to;Fishes;Funding;granite;Hair;Health Policy;Human;Individual;Inductively Coupled Plasma Mass Spectrometry;Infant;Inorganic Chemistry;Institution;instrument;instrumentation;International;Invertebrates;Iron;Link;Malignant Neoplasms;Measures;member;Methods;Micronutrients;Monitor;nanoparticle;NCI Center for Cancer Research;Norris Cotton Cancer Center;Placenta;Platinum;Play;Population Sciences;Preparation;programs;Protocols documentation;Public Health;quality assurance;Quality Control;Research;Research Personnel;Resource Sharing;Resources;Role;Running;Sampling;Selenium;Services;Soil;Structure of nail of toe;Technology;Testing;Therapeutic Effect;Therapeutic Uses;Tissues;Trace Elements;Urine;Water;Work

PROJECT_TITLE: Trace Elements (TE)


NIH_SPENDING_CATS: Behavioral and Social Science;Breast Cancer;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Lung Cancer;Palliative Care;Prevention;Social Determinants of Health;Women's Health Research

PI_NAMEs: CHRISTENSEN, BROCK CLARKE (contact)

PROJECT_TERMS: advanced disease;Area;Arsenic;Award;Basic Science;Behavioral;Breast Cancer Detection;Cancer Burden;Cancer Center Support Grant;cancer epidemiology;Cancer Etiology;cancer genetics;cancer prevention;cancer risk;Cancer Science;care delivery;Catchment Area;Child;Clinic;Clinical;Clinical effectiveness;Collaborations;colon cancer screening;Data;design;Development;Direct Costs;Discipline;Educational workshop;Electronic cigarette;Epidemiologic Factors;exercise intervention;Faculty;Fostering;Funding;Future;Geography;Goals;Grant;Growth;Health;health care delivery;Healthcare;Heavy Metals;implementation research;improved;Incidence;Institution;Interdisciplinary Study;interest;Intervention;Investigator-Initiated Research;Journals;Life Cycle Stages;lung cancer screening;Malignant Breast Neoplasm;Malignant Neoplasms;Marketing;Medical center;medical schools;meetings;member;Mentors;Mentorship;Metal exposure;microbiome;Molecular;Multicenter Studies;NCI-Designated Cancer Center;new technology;next generation;Obesity;Outcome;Palliative Care;Paper;patient population;Patients;Peer Review;Persons;Physicians;Policies;Polyp Prevention Trial;Population;population health;Population Sciences;Population Study;Poverty;Prevention;Productivity;programs;Publications;Publishing;Quality of Care;Quality of life;Recording of previous events;recruit;Reporting;Research;Research Personnel;Resource Sharing;Risk;Risk Behaviors;Risk Factors;Risk Reduction;Risk Reduction Behavior;Rural;rural patients;Rural Population;Science;Scientist;screening;Screening for cancer;senior faculty;Services;severe mental illness;smoking cessation;State Government;Sum;survivorship;Testing;Tobacco;Training;Training Programs;Travel;United States Department of Veterans Affairs;Vulnerable Populations;well water;Work;working group

PROJECT_TITLE: Cancer Population Sciences (CPS)


PI_NAMEs: GERBER, SCOTT A. (contact)

PROJECT_TERMS: Acceleration;Award;Back;Basic Cancer Research;Basic Science;Biological Models;Biology;Breast;Cancer Biology;cancer cell;Cancer Center Support Grant;cancer diagnosis;cancer initiation;cancer therapy;cancer type;Catchment Area;Cell Cycle;Cellular Metabolic Process;Chromatin;Classification;Clinic;Clinical;clinical application;clinical development;Clinical Research;clinical translation;Clinical Trials;Collaborations;design;Development;Diagnosis;Diagnostic;diagnostic strategy;Direct Costs;Discipline;early phase trial;Exclusion;Extramural Activities;Faculty;Fostering;Funding;Genetic Transcription;Genome Stability;Goals;graduate school;improved;innovation;insight;Institution;interdisciplinary collaboration;Interdisciplinary Study;interest;Invaded;Investigational Therapies;Joints;Journals;Knowledge;Laboratories;Laboratory Finding;Laboratory Scientists;Lung;Malignant Neoplasms;Measures;Medical center;Medical Oncologist;medical schools;member;Mentors;Mentorship;Molecular;Molecular Target;Movement;multidisciplinary;Natural History;NCI Center for Cancer Research;Neoplasm Metastasis;New England;Norris Cotton Cancer Center;novel;novel diagnostics;novel therapeutics;Oncogenic;Pathway interactions;patient population;Peer Review;Physicians;Play;Prevention;Productivity;programs;Publications;recruit;Reporting;Research;Research Activity;Research Personnel;Resource Sharing;Role;Rural;rural patients;Schools;scientific organization;Scientist;Services;Signal Transduction;Sum;Surgical Oncologist;Therapeutic;Therapeutic Intervention;Therapeutic Research;therapeutically effective;Training;translational cancer research;Translational Research;translational scientist;translational study;Translations;Validation

PROJECT_TITLE: Cancer Biology and Therapeutics (CBT)


PI_NAMEs: PAULSEN, KEITH D. (contact)

PROJECT_TERMS: Acceleration;Advocate;anti-cancer research;Articulation;Award;base;Biomedical Engineering;Biophotonics;Biophysics;Brain;Breast;cancer care;Cancer Center;Cancer Center Support Grant;Cancer Detection;Cancer Patient;Cancer Research Project;Capital;Catchment Area;Clinical;Clinical Investigator;Clinical Oncology;clinical practice;Clinical Research;Collaborations;Computational Science;computer science;design;Detection;Development;Diagnosis;Direct Costs;dosimetry;Engineering;Environment;Evaluation;Exclusion;Extramural Activities;Faculty;Faculty Recruitment;Fostering;Funding;Future;Goals;graduate school;Grant;Head and neck structure;Health;Image;Image Enhancement;image guided;Image-Guided Surgery;imaging facilities;imaging modality;improved;Industry;industry partner;innovation;Institution;interdisciplinary collaboration;interest;Intervention;Investments;Journals;Laboratories;Legal patent;Malignant Neoplasms;Medical;Medical center;Medical Oncology;medical schools;Medicine;member;Mentors;Mission;Molecular;Monitor;multidisciplinary;new technology;Norris Cotton Cancer Center;novel;Operative Surgical Procedures;Pancreas;Pathology;Peer Review;Physicians;Physics;Point of Care Technology;Postdoctoral Fellow;pre-doctoral;Procedures;Program Development;programs;Prostate;Protocols documentation;Publications;Radiation Monitoring;Radiation Oncology;Radiation therapy;Radiology Specialty;Research;research faculty;Research Personnel;Research Project Grants;Resources;Rural;Schools;Services;Skin;Specialist;success;Sum;Surgical Oncology;Surgical Specialties;Technical Expertise;Technology;Technology Assessment;technology development;Testing;Training;Translating;translational goal;Translations;Work

PROJECT_TITLE: Translational Engineering in Cancer (TEC)


NIH_SPENDING_CATS: Biotechnology;Cancer;Immunotherapy

PI_NAMEs: TURK, MARY JO  (contact)

PROJECT_TERMS: Address;Advanced Development;Advocate;Antitumor Response;Applications Grants;Area;Award;bench to bedside;Cancer Biology;Cancer Center;Cancer Center Support Grant;cancer immunotherapy;Cancer Patient;cancer therapy;CAR T cell therapy;career;Cellular biology;chimeric antigen receptor T cells;Clinical;Clinical Research;Clinical Trials;Collaborations;Development;Direct Costs;drug efficacy;engineered T cells;Engineering;Ensure;Equipment;Exclusion;Faculty;Fostering;Funding;Future;Goals;Grant;Health;Health system;Human;Image;Immune;immune checkpoint blockade;Immune checkpoint inhibitor;Immune system;Immunologics;Immunologist;Immunology;immunoregulation;Immunotherapeutic agent;Immunotherapy;immunotherapy clinical trials;improved;innovation;Institution;interest;Intervention;Journals;Laboratories;Laboratory Finding;Leadership;Ligands;Malignant Neoplasms;medical schools;meetings;member;Mentors;Mentorship;Mission;Modality;Molecular;mosaic;novel;Patients;Peer Review;Population Sciences;pre-clinical;programs;Publications;Radiobiology;recruit;Research;Research Personnel;Research Support;Resources;Schools;Scientist;standard of care;success;Sum;T memory cell;T-Lymphocyte;Therapeutic;therapeutic nanoparticles;Training;Translating;translational immunology;tumor immunology;tumor microenvironment;United States National Institutes of Health;viral nanoparticle;Work;working group;Writing

PROJECT_TITLE: Immunology and Cancer Immunotherapy (ICI)


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Social Determinants of Health

PI_NAMEs: TOSTESON, ANNA N. A. (contact)

PROJECT_TERMS: Achievement;Address;Affect;Age;anti-cancer research;Area;Automobile Driving;base;Cancer Biology;Cancer Burden;Cancer Center;Cancer Center Support Grant;Cancer Control;Cancer health equity;cancer site;Cancer Survivor;Catchment Area;Categories;Classification;Clinical Research;Clinical Trials;Code;Collaborations;Communities;community advisory board;community collaboration;community engaged intervention;community engagement;Community Outreach;community research;Comprehensive Cancer Center;County;Data;Death Rate;Disparity;Early Diagnosis;economic determinant;Education;Ensure;Ethnic Origin;Etiology;Event;Grant;Health behavior;health equity;Health Service Area;Health Services Accessibility;Health system;Incidence;Income;Individual;Infrastructure;Intervention;Knowledge;Malignant Neoplasms;Measures;metropolitan;Mission;Monitor;mortality;NCI Center for Cancer Research;NCI-Designated Cancer Center;New England;Norris Cotton Cancer Center;Observational Study;Play;Policies;Population;population migration;Prevalence;Prevention;programs;Publications;Race;Research;research study;Resources;Risk;Risk Factors;Role;Rural;rural area;Rural Community;Rural Population;screening;social determinants;Solid;survivorship;Translating;Translations;Underserved Population;Work

PROJECT_TITLE: Community Outreach and Engagement


NIH_SPENDING_CATS: Biotechnology;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

PI_NAMEs: LEACH, STEVEN D (contact)

PROJECT_TERMS: Award;Biometry;Cancer Center Support Grant;cancer research center director;Cells;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;college;Coupled;Development;Direct Costs;Emerging Technologies;Engineering;Evaluation;Faculty;Faculty Recruitment;Funding;Funding Mechanisms;Gene Transfer;Genomics;Health;Immunooncology;Individual;Infrastructure;innovation;Investments;Malignant Neoplasms;member;Molecular Biology;mouse model;NCI Center for Cancer Research;Needs Assessment;Norris Cotton Cancer Center;novel;Pathology;patient derived xenograft model;Peer Review;Philanthropic Fund;Pilot Projects;Population Research;precision oncology;preference;Prevention;Process;programs;Publications;Radar;Recording of previous events;recruit;Registries;Reporting;Research;Research Personnel;Resource Sharing;Resources;Rural Population;Science;Secure;Service provision;Services;Strategic Planning;survivorship;System;Techniques;Translational Research;Work

PROJECT_TITLE: Developmental Funds


PROJECT_TERMS: Achievement;Applications Grants;Area;Award;Cancer Center Support Grant;Capital;career;clinical implementation;Collaborations;Communities;community engagement;Community Outreach;Development;Engineering;Environment;Evaluation;expectation;experience;Faculty Recruitment;Formulation;Funding;Future;Goals;Immunology;Individual;insight;Institution;Intellectual Property;Investments;Leadership;member;multidisciplinary;NCI Center for Cancer Research;Norris Cotton Cancer Center;Parents;peer;Peer Review;Population Sciences;Positioning Attribute;Process;programs;Qualifying;Recommendation;Research;Research Infrastructure;Resource Sharing;Role;Science;Secure;Services;Strategic Planning;Strategic vision;Training;Translations;Vision;Work

PROJECT_TITLE: Leadership, Planning and Evaluation


NIH_SPENDING_CATS: Cancer;Patient Safety

PI_NAMEs: DRAGNEV, KONSTANTIN H. (contact)

PROJECT_TERMS: Address;Adult;Adverse event;Amendment;American College of Radiology Imaging Network;anti-cancer research;authority;Cancer Center;Cancer Center Support Grant;Cancer Patient;Catchment Area;Charge;Childhood;Clinical;Clinical Cancer Center;Clinical Data;Clinical Management;Clinical Protocols;Clinical Research;clinical trial participant;Clinical Trials;Clinical Trials Data Monitoring Committees;Data;data integrity;data management;Early Therapeutic-Clinical Trials Network;Eastern Cooperative Oncology Group;Enrollment;experience;Failure;Female;Goals;Health system;improved;Industry;Institution;Institutional Review Boards;Intervention Trial;investigator-initiated trial;Lead;Malignant Neoplasms;member;Monitor;Monitoring Clinical Trials;multidisciplinary;NCI Center for Cancer Research;Norris Cotton Cancer Center;Nursing Research;Office Management;Parents;Participant;participant safety;Patients;Pharmacy facility;Phase;Population;programs;protocol development;Protocols documentation;Qualifying;Reapplication;Recommendation;Reporting;Research;Research Personnel;research study;Resources;Review Committee;Risk;Safety;screening;Serious Adverse Event;Services;Site;Study Subject;Woman

PROJECT_TITLE: Clinical Protocol and Data Management (CPDM)


NIH_SPENDING_CATS: Cancer;Patient Safety;Prevention

PROJECT_TERMS: Advocacy;Amendment;authority;Basic Science;behavioral study;Biomedical Engineering;Biometry;Cancer Center;Cancer Center Support Grant;cancer prevention;Charge;Clinical;Clinical Oncology;Clinical Pharmacology;Clinical Research;Clinical Trials;Collection;college;Committee Members;Communication;Data;Discipline;Enrollment;falls;Funding Agency;Hematology;human subject;human subject protection;Immunology;Institutional Review Boards;Intervention;Intervention Trial;Light;Logistics;Malignant Neoplasms;Medical Oncology;member;Modification;Monitor;multidisciplinary;NCI Center for Cancer Research;Norris Cotton Cancer Center;Oncology;Oncology Group;Participant;participant safety;Pathology;Patient Outcomes Assessments;patient population;Pediatric Oncology;Peer Review;Population;Population Sciences;Principal Investigator;Process;programs;Protocols documentation;Published Comment;Quality of life;Radiation Oncology;Recommendation;Regulation;Research;Research Activity;research study;Review Committee;Safety;safety outcomes;screening;Suggestion;Surgical Oncology;survivorship;System;Time;United States National Institutes of Health

PROJECT_TITLE: Protocol Review and Monitoring System (PRMS)


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Eye Disease and Disorders of Vision;Gene Therapy;Genetics;Hearing Loss;Neurosciences;Rare Diseases;Usher Syndrome

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS EYE AND EAR INFIRMARY

ORG_STATE: MA

PHR: The advent of successful gene therapy for certain retinal disorders and our extensive knowledge of the dozens of genes involved in hereditary hearing loss, together raise hope that gene therapy can be used to treat genetic forms of hearing loss. For instance mutations in the PCDH15 gene cause Usher syndrome type 1F, a devastating deafness, blindness and balance disorder. While we and others have achieved success in mouse models using gene therapy for short genes that will fit in adeno-associated virus (AAV) vectors, PCDH15 is a long gene that does not fit into AAV; thus we propose to engineer short “mini-PCDH15” proteins, to test rescue of hearing and balance in mice, and to test localization and toxicity in nonhuman primates.

PI_NAMEs: COREY, DAVID P;INDZHYKULIAN, ARTUR  (contact);SOTOMAYOR, MARCOS

PROGRAM_OFFICER_NAME: WATSON, BRACIE

PROJECT_TERMS: adeno-associated viral vector;Binding;Blindness;C-terminal;Clinic;Code;congenital deafness;deafness;Dependovirus;Development;Disease;Ear;Engineering;equilibration disorder;Equilibrium;Eye;gene therapy;Genes;Genetic;genetic deafness;Hearing;hearing impairment;hereditary blindness;hereditary hearing loss;in silico;In Vitro;Inherited;Knockout Mice;Knowledge;Labyrinth;Love;Mechanical Stress;Mendelian disorder;Methods;mouse model;Mus;mutant;Mutate;Mutation;N-terminal;Nervous System Disorder;nonhuman primate;novel;Parents;Pathology;Patients;PCDH15 gene;Persons;preclinical evaluation;Protein Chemistry;Protein Engineering;Proteins;rapid technique;Retinal Diseases;Single-Gene Defect;structural biology;Structural Protein;Structure;success;Testing;Toxic effect;Usher Syndrome;Vestibular function

PROJECT_TITLE: Development of Gene Therapy for Hereditary Deafness using Rational Protein Engineering


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Aging;Brain Disorders;Clinical Research;Digestive Diseases;Endocrine Disruptors;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Microbiome;Neurodegenerative;Neurosciences;Parkinson's Disease;Prevention;Rural Health;Social Determinants of Health

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Narrative We will study the impact of high and chronic pesticide exposures in a rural environment on the gut microbiome of Parkinson’s disease (PD) patients, their household members and healthy community controls and its contributions to progression of PD. This research will be highly efficient due to our access to an existing cohort of PD patients and unaffected community controls - who live in a heavily agriculturally pesticide exposed area of California – and a network of rural health care providers. Our research may discovery novel etiological pathways for pesticide action through the microbiome, propose interventions to prevent PD progression, and change public policy and pesticide regulations.

PI_NAMEs: RITZ, BEATE R. (contact)

PROGRAM_OFFICER_NAME: DZIERLENGA, ANIKA LIN

PROJECT_TERMS: Address;Affect;Age;agricultural pesticide;Air Pollution;alpha synuclein;Animals;Area;Assessment tool;Behavior;Biological;Biological Models;Blood;Blood specimen;Brain;Brain Pathology;California;Chronic;Clinical;Clinical Data;Cognitive;cohort;Communities;Constipation;Cross-Sectional Studies;Data;Development;Diet;Digestive System Disorders;Disease;disease diagnosis;Disease Progression;Elderly;Enrollment;Enteric Nervous System;Environment;Environmental Exposure;Environmental Impact;Environmental Risk Factor;Etiology;experience;experimental study;Exposure to;Feces;follow-up;Funding;gastrointestinal;gastrointestinal symptom;Gastroparesis;gene environment interaction;Genes;Genetic;Geographic Information Systems;gut inflammation;gut microbiome;gut microbiota;gut-brain axis;Health Personnel;Household;Human;Human Microbiome;human microbiota;Immune system;Impaired cognition;Inflammation;insight;Intervention;Lewy Bodies;Life Style;Longitudinal Studies;Measures;Mediating;Medical;member;Metabolic Pathway;metabolomics;metagenome;Metagenomics;Metals;Microbe;microbiome;microbiome composition;microbiome research;microbiota;Motility;Motor;motor impairment;Nerve Degeneration;Nervous System Physiology;Neurodegenerative Disorders;non-motor symptom;novel;Nutrient;Onset of illness;Parkinson Disease;parkinson's disease registry;Participant;Pathologic;Pathway interactions;Patients;pesticide exposure;pesticide interaction;Pesticides;Pharmaceutical Preparations;Phenotype;Physiology;Play;Population;Population Study;prevent;Prevention;Process;protein aggregation;Public Policy;Records;recruit;Regulation;Reporting;Research;Resources;RNA, Ribosomal, 16S;Role;rural environment;rural health network;Serum;sex;Shotguns;Specificity;stool sample;Susceptibility Gene;System;Testing;Time;time use;tool;Toxin;uptake

PROJECT_TITLE: Microbiome, Environment, and Parkinsons disease (MEP) PESTICIDE EXPOSURES AND THE GUT MICROBIOME IN PARKINSONS DISEASE

STUDY_SECTION: NAME

STUDY_SECTION_NAME: Neurological, Aging and Musculoskeletal Epidemiology Study Section[NAME]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Clinical Research;Data Science;Dental, Oral, and Craniofacial Disease;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Precision Medicine;Prevention

ORG_NAME: ILLINOIS INSTITUTE OF TECHNOLOGY

PHR: The primary objective of the proposed project is to develop a saliva-based biosensor by integrating research advances in sensing elements, machine learning, data analysis, microfluidics and communications for periodontal disease prediction which has high public health relevance. We will establish predictive models for periodontitis based on data from both sensor and patient. The new device will be useful for saliva-based self-monitoring for periodontitis and other oral or systemic diseases to improve the patient's overall health.

PI_NAMEs: MATHEW, MATHEW THOPPIL;WANG, RONG R. (contact)

PROGRAM_OFFICER_NAME: OKI, NOFFISAT

PROJECT_TERMS: Address;Adult;aged;Area;Artificial Intelligence;Awareness;Bioinformatics;Biological Markers;Biology;Biosensor;bone;bone loss;care systems;Caring;Categories;Clinical;clinical decision support;clinical examination;Collection;Communication;comorbidity;Computational Biology;computerized data processing;cost;craniofacial;Data;Data Analyses;data modalities;Data Reporting;Data Science;deep learning;Dental;Dentists;design;Detection;Devices;Diagnosis;Diagnostic;diagnostic value;Dimensions;Disease;disease diagnosis;disorder control;disorder risk;diverse data;Early Diagnosis;Elements;empowerment;Future;Goals;Health;Healthcare;Home;human subject;improved;indexing;Individual;individual patient;Inflammation;Inflammatory;innovation;Intervention;Knowledge;Lab On A Chip;Label;Learning;liquid biopsy;Machine Learning;machine learning framework;machine learning method;machine learning model;Measurement;Measures;Mediator;Medical;microbial;Microfluidic Microchips;Microfluidics;miniaturize;Modality;Monitor;Mouth Diseases;multimodality;nano;nanoparticle;nanopore;National Institute of Dental and Craniofacial Research;novel;Oral;oral care;Oral health;Output;Pain;Patients;Periodontal Diseases;Periodontitis;personalized medicine;point of care;Prediabetes syndrome;predictive modeling;Privacy;procedure cost;Process;programs;prototype;public health relevance;Research;risk prediction;Saliva;Salivary;Sampling;Secure;sensor;signal processing;Signal Transduction;soft tissue;solid state;Students;System;Systemic disease;teacher;tool;Tooth structure;Training;transmission process;user protection;user-friendly

PROJECT_TITLE: SCH: Multidimensional Microfluidic Salivary Sensor with Adversarial Knowledge Distillation for Point-of-Care Assessment of Periodontitis and Comorbidities

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-VH-N(50)]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Homelessness;Social Determinants of Health

ORG_CITY: UNIVERSITY PARK

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

PHR: Project Narrative Over fifty years of punitive criminal justice policies have created a growing population of older incarcerated individuals who are now eligible for community release but lack the social or economic capital to rebuild their lives. This study will evaluate a novel peer-run program based on network principles (i.e., social support, group cohesion, and shared instrumental resources) to help older, previously incarcerated men transition from prison to the community.

PI_NAMEs: KREAGER, DEREK ALLEN (contact)

PROGRAM_OFFICER_NAME: GERALD, MELISSA S

PROJECT_TERMS: acceptability and feasibility;access restrictions;Address;Affect;Aging;Area;Attitude;Automobile Driving;Basic Science;behavioral health;behavioral outcome;Capital;Case Study;Characteristics;cohesion;Communities;community building;contextual factors;court;Criminal Justice;Data;design;Development;Economics;Educational workshop;Effectiveness;efficacy evaluation;Eligibility Determination;Employment;Ethnography;Evaluation;experience;Family;Friendships;Funding;Future;Gerontology;Health;health care availability;health data;housing instability;Iatrogenesis;implementation evaluation;implementation process;implementation science;Imprisonment;improved;Individual;infancy;innovation;Institution;Interpersonal Relations;Intervention;Interview;Label;Leadership;Life Cycle Stages;Link;Maps;Measures;Medicaid services;Medicare/Medicaid;men;Methods;Modeling;multidisciplinary;Network-based;novel;older adult;older men;Older Population;open source;Outcome;Participant;Pathway Analysis;peer;Pennsylvania;Perception;Policies;Population;Population Intervention;prison population;Prisons;Process;Program Description;Program Development;programs;Property;Psychological reinforcement;rearrest;Records;reincarceration;Research;Research Design;residence;Resources;response;Running;Sample Size;Sampling;Shapes;social;social health determinants;Social Network;Social outcome;social relationships;Social support;Social Work;Statistical Models;Surveys;therapy design;Time;transitional housing;Translations;treatment services;Trust;United States National Institutes of Health;Vulnerable Populations;Work

PROJECT_TITLE: Community Building among Older Men Returning from Incarceration: The Cumberland House Reentry Project (CHRP)