NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Mental Illness;Post-Traumatic Stress Disorder (PTSD);Sleep Research;Substance Misuse;Violence Research

ORG_CITY: VERMILLION

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF SOUTH DAKOTA

ORG_STATE: SD

PHR: Public Health Narrative This research will increase understanding of factors maintaining AUD and PTSD among veterans, an important public health concern. It will advance knowledge of regulatory processes underlying comorbid AUD and PTSD and associated problems with interpersonal functioning (e.g., violence). Whereas previous research has studied emotional and behavioral dysregulation as person-level correlates of PTSD and AUD, this study shifts the focus to advance knowledge of the temporal dynamics of these processes to identify time-varying precursors of health outcomes.

PI_NAMEs: SIMONS, JEFFREY S (contact);SIMONS, RALUCA M

PROGRAM_OFFICER_NAME: TUMA, FARRIS KEITH

PROJECT_TERMS: actigraphy;Acute;Acute Post Traumatic Stress Disorder;Address;Affect;Affective;alcohol comorbidity;Alcohol consumption;alcohol effect;alcohol use disorder;Alcoholic beverage heavy drinker;Alcohols;Area;Arousal;Attenuated;Behavior;behavior influence;Behavioral;behavioral disinhibition;Cognition;Cognitive;common symptom;comorbidity;Consumption;Cues;daily functioning;Data;Data Analytics;Data Set;design;Disinhibition;Emotional;Exhibits;experience;Experimental Designs;experimental study;follow-up;Health;Impairment;implicit bias;Individual;Informal Social Control;innovation;interpersonal conflict;Intervention;Intoxication;Knowledge;Link;Literature;Measures;Mediating;Methods;Modeling;Modification;Neurosciences;Nightmare;Outcome;Participant;Pathway interactions;Persons;poor sleep;Post-Traumatic Stress Disorders;Process;Protocols documentation;Public Health;Randomized;Regulation;Research;Research Subjects;response;Risk Behaviors;Risk Factors;Role;Sampling;Sampling Studies;Self Medication;sensor;Severities;sexual trauma;Site;Sleep;Sleep disturbances;sleep quality;Social Functioning;Surveys;Symptoms;Testing;Time;Training;Trauma;traumatic stress;Treatment outcome;Veterans;Violence

PROJECT_TITLE: PTSD, AUD, and Interpersonal Conflict: Within-person associations


ADMINISTERING_IC: AR

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: ITHACA

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOCHEMISTRY

ORG_FIPS: US

ORG_NAME: CORNELL UNIVERSITY

ORG_STATE: NY

PHR: Epidermal stem/progenitor cells of the adult skin are highly active and their response to normal and injury-generated signals is essential for organismal survival. Although it is a rapidly developing area of research, the heterogeneity, hierarchical lineage relationship, and the spatial distribution of diverse epidermal stem/progenitor cell populations in the mouse and human skin are poorly understood. Our laboratory has identified heterogeneity of the basal skin cells, containing stem/progenitor cells, and suggested a spatial patterning of distinct stem cell distribution that has the potential to advance our understanding in the area of human skin regeneration and wound healing.

PI_NAMEs: TUMBAR, TUDORITA  (contact)

PROGRAM_OFFICER_NAME: KOCH, PETER

PROJECT_TERMS: 3-Dimensional;Acute;Adult;Architecture;Area;Basal Cell;Behavior;behavior change;Biological;Cell Lineage;Cell model;Cell Proliferation;Cell Survival;cell type;Cells;Complex;Data;Development;Epidermal Ridges;epidermal stem cell;Epidermis;Extinction;Genetic;Growth;Heterogeneity;Homeostasis;Human;in vivo;Injury;injury and repair;Label;Laboratories;Light;Link;Lymphatic;Modeling;Molecular;molecular domain;mouse genetics;Mus;Natural regeneration;novel;Pattern;Phase;Physiological;Population;Proliferating;regeneration potential;regenerative;Regenerative capacity;regenerative cell;regenerative healing;Research;response;Science;Shapes;Signal Transduction;Skin;skin organogenesis;skin regeneration;SOX6 gene;Spatial Distribution;stem;stem cell population;stem cells;Stratum Basale;Structure;Study models;Tail;Time;Tissues;tool;transcription factor;transcriptomics;UV induced;UV Radiation Exposure;UV response;Work;wound healing

PROJECT_TITLE: Defining the heterogeneity of cell lineages in the inter-follicular epidermis


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Substance Misuse

ORG_CITY: LUBBOCK

ORG_DEPT: CHEMISTRY

ORG_NAME: TEXAS TECH UNIVERSITY

ORG_STATE: TX

PHR: K+ channels and chemokine G protein-coupled receptors are involved in progression of diverse diseases, from Parkinson’s and Alzheimer’s to drug addiction and autoinflammatory conditions. Yet, molecular mechanisms by which disease development and severity occurs is not well understood. Our goal is to gain insight into human pathophysiology through biochemical characterization of these complicated systems.

PI_NAMEs: WYLIE, BENJAMIN JAMES (contact)

PROGRAM_OFFICER_NAME: NIE, ZHONGZHEN

PROJECT_TERMS: Affinity;Alzheimer's Disease;autoinflammatory;Bartter Disease;Binding;Biochemical;Biological;Biological Assay;CC chemokine receptor 3;CCL11 gene;Chemicals;chemokine;chemokine receptor;Chimera organism;Cholesterol;Complement;Complex;COVID-19 cytokine storm;Data;Development;dimer;Dimerization;Disease;Docking;Dose;Drug Addiction;Environment;Epilepsy;Event;Family;Fluorescence;Freezing;Functional disorder;G-Protein-Coupled Receptors;GIRK2 subunit, G protein-coupled inwardly-rectifying potassium channel;Goals;GTP-Binding Proteins;HIV;Human;Hypoglycemia;insight;interfacial;Ligand Binding;ligand gated channel;Lipid Bilayers;Lipids;Long QT Syndrome;Measurement;Measures;Membrane;Membrane Lipids;Membrane Proteins;Molecular;Molecular Conformation;molecular dynamics;Neoplasm Metastasis;Nuclear;Parkinson Disease;periodic paralysis;Phosphatidylinositol 4,5-Diphosphate;Phosphatidylinositols;Potassium Channel;protein structure;Proteins;proteoliposomes;receptor;Role;Severities;Signal Transduction;solid state nuclear magnetic resonance;Structure;Substance abuse problem;System;targeted therapy trials;Techniques;voltage;Water

PROJECT_TITLE: The Functional Interplay of Lipid Membrane Components: Activation, Inhibition, and Raft Formation.


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_CITY: KANSAS CITY

ORG_NAME: STOWERS INSTITUTE FOR MEDICAL RESEARCH

ORG_STATE: MO

PHR: 8. Public Health Relevance.  Interneuronal connection in the nervous system is essential for the proper function of the brain. Cognitive deficits in many psychiatric disorders arise from disruptions in neural connectivity, including disruptions within sensory circuits. The proposed study investigates the role of intercortical neuronal connections in in regulating sensory information processing and perceptual experience. Results from this study will reveal how brain function can deteriorate because of disruptions in the normal connection patterns among neurons. This information is important to provide deep understanding of normal and pathological function of the nervous systems.

PI_NAMEs: CLELAND, THOMAS A;LIN, YINGXI ;YU, CONGRONG RON (contact)

PROGRAM_OFFICER_NAME: SABRI, MERAV

PROJECT_TERMS: Affect;Anatomy;Animal Model;Animals;Architecture;Area;Axon;Behavior;Behavioral Assay;Brain;Categories;Cells;Code;Cognitive deficits;Detection;Deterioration;Discrimination;Discrimination Learning;experience;experimental study;Funding;Genetic;genetic approach;Goals;Habitats;Image;information processing;insight;interdisciplinary approach;Interneurons;Label;Learning;Light;Maps;Memory;Mental disorders;Molecular;Mus;Nervous System;Nervous System Physiology;neural;Neurons;Odorant Receptors;Odors;olfactory bulb;olfactory bulb glomeruli;Olfactory Cortex;Olfactory Pathways;olfactory sensory neurons;optogenetics;Output;Pathologic;Pattern;Perception;piriform cortex;Play;Population;Process;public health relevance;receptor;Resolution;response;Role;segregation;Sensory;sensory system;Signal Transduction;Smell Perception;Stable Populations;Stereotyping;Stimulus;Structure;Testing;Tetanus Toxin;Theoretical model;tool;Training

PROJECT_TITLE: Circuit architecture and dynamics in odor representation and perception


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Aging;Biomedical Imaging;Cancer;Clinical Research;Genetic Testing;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Prevention;Prostate Cancer;Racial and Ethnic Minority Health Research;Urologic Diseases

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE The premise of this proposal is that an optimal early detection strategy to identify clinically relevant prostate cancer will involve a two-tiered algorithm that leverages inherited genetic information to determine who is at risk for prostate cancer followed by MRI imaging to determine which of these high risk patients has clinically relevant disease. We propose to test this premise by implementing a polygenic risk score in men and conducting a prospective trial among 1,500 men with MRI to prove the two-tiered algorithm works.

PI_NAMEs: KIBEL, ADAM S (contact)

PROGRAM_OFFICER_NAME: MARQUEZ, GUILLERMO

PROJECT_TERMS: Address;Age;age group;age stratification;Age Years;Algorithms;Artificial Intelligence;artificial intelligence algorithm;biobank;Biological Markers;Biopsy;black men;Black race;Cancer Etiology;Cessation of life;Clinical;clinical center;clinical practice;clinical risk;clinically relevant;clinically significant;cohort;Data;deep learning;Diagnosis;Disease;disorder risk;DNA Repair;Early Diagnosis;Ensure;Evaluation;evidence based guidelines;follow-up;gene repair;General Population;Genetic;genetic information;Genetic Risk;genetic testing;genetic variant;genome wide association study;Genotype;Germ Lines;Gleason Grade for Prostate Cancer;Goals;Heritability;high risk;high risk men;Hospitals;Human;Image;improved;Incidence;Inherited;Institution;Knowledge;Lesion;Life;Magnetic Resonance Imaging;Malignant neoplasm of prostate;Malignant Neoplasms;man;Medical center;men;Military Personnel;mortality;MRI Scans;multi-ethnic;National Cancer Institute;novel;overtreatment;Pathway interactions;patient population;Patients;polygenic risk score;Population;population based;Populations at Risk;premalignant;Primary Care;programs;Prophylactic treatment;prospective;Prospective cohort;prostate cancer prevention;prostate cancer risk;Public Health Schools;racial disparity;racial diversity;radiologist;rare variant;recruit;Resources;Risk;risk prediction;risk stratification;Role;screening;Screening for Prostate Cancer;serial imaging;Serial Magnetic Resonance Imaging;Single Nucleotide Polymorphism;stem;Testing;Time;tool;Translating;Translations;trial design;tumor;United States;United States National Institutes of Health;Universities;University Hospitals;Variant;wasting;Woman;Work

PROJECT_TITLE: Polygenic risk stratification combined with mpMRI to identify clinically relevant prostate cancer


ADMINISTERING_IC: TR

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities

ORG_CITY: INDIANAPOLIS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Project Narrative The primary objective of this new K12 Mentored Research Career Development Program at the Indiana Clinical and Translational Sciences Institute is to provide a diverse group of early career faculty Scholars intensive mentored career development experiences that lead to research independence and prepare them for leadership positions in clinical and translational science. Our K12 program is designed to provide: 1) mentored research experience, 2) research project support, and 3) career development training in clinical and translational science, with directed attention to diversity, equity, and inclusion. We are confident that we will attract diverse, high caliber applicants and mentor them toward impactful careers in clinical and translational research.

PI_NAMEs: GUPTA, SAMIR KUMAR (contact)

PROGRAM_OFFICER_NAME: NAGEL, JOAN DAVIS

PROJECT_TERMS: Acceleration;Address;Area;Award;Caliber;career;career development;Clinical Research;Clinical Sciences;Companions;design;Development;early-career faculty;Ensure;equity, diversity, and inclusion;evidence base;experience;faculty mentor;Funding;Goals;Grant;Indiana;Individual;Institution;Knowledge;Leadership;Mentored Clinical Scientist Development Program;Mentors;Population;Positioning Attribute;Principal Investigator;Program Development;programs;Recording of previous events;recruit;Research;Research Activity;Resources;Science;Scientist;Secure;skills;Time;Training;Translational Research;Universities;Work;Workforce Development

PROJECT_TITLE: CTSA K12 Program at Indiana University


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Sleep Research

ORG_CITY: Columbus

ORG_DEPT: NEUROSCIENCES

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Alzheimer’s disease is an irreversible neurodegenerative disorder that affects over 35 million people worldwide and is the fifth leading cause of death in the elderly. Currently, limited clinical interventions are available, and as such, there is an urgent need to further our understanding of the molecular mechanisms that underlie AD, and in turn, to utilize these findings to develop novel therapeutic approaches. In line with these goals, the work proposed here explores an understudied and potentially critical connection between dysregulation of the circadian timing system and the cognitive deficits that are a defining feature of Alzheimer’s disease.

PI_NAMEs: HOYT, KARI RENE;OBRIETAN, KARL H (contact)

PROGRAM_OFFICER_NAME: MACKIEWICZ, MIROSLAW

PROJECT_TERMS: abeta oligomer;Affect;Alzheimer like pathology;Alzheimer's Disease;Alzheimer's disease model;Amyloid beta-Protein;amyloidogenesis;Animals;Basic Science;Behavioral;Brain;Brain region;Cause of Death;Cell Culture Techniques;Cells;Cephalic;circadian;Circadian Dysregulation;circadian pacemaker;Circadian Rhythms;Clinical;Clinical Research;Cognition;Cognitive deficits;Complex;Confocal Microscopy;cortico-limbic circuits;CREB1 gene;Data;Dendritic Spines;design;Disease;Disease Progression;Elderly;experimental study;frontal lobe;Functional disorder;functional plasticity;Gene Expression;Generations;Genes;Genetic;Goals;Hippocampus;Hour;Image;imaging modality;Immunofluorescence Immunologic;in vivo;Individual;innovation;Intervention;Learning;MAP Kinase Gene;Modeling;Molecular;mouse model;Multiphoton Fluorescence Microscopy;multiphoton microscopy;Mus;neural;Neurodegenerative Disorders;Neurons;novel therapeutic intervention;overexpression;Pathogenesis;Pathology;Pathway interactions;Persons;Phase;Population;Prosencephalon;Reporter;Reporter Genes;research study;Role;Series;Signal Pathway;Signal Transduction;Slice;Structure;suprachiasmatic nucleus;Synaptic plasticity;System;Testing;transcriptomic profiling;Transgenic Mice;Transgenic Organisms;Venus;Work

PROJECT_TITLE: Alzheimer's disease pathogenesis and the desynchronization of cortico-limbic circadian rhythms

STUDY_SECTION: NNRS

STUDY_SECTION_NAME: Neuroendocrinology, Neuroimmunology, Rhythms and Sleep Study Section[NNRS]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

ORG_CITY: Los Angeles

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

ORG_STATE: CA

PHR: Project Narrative In the current proposal, we will examine whether adults from Black, Indigenous and Persons of Color communities, who have been and are still impacted by health disparities, increase their use of two or more substances (cigarettes, e-cigarettes, marijuana and/or alcohol) when they experience discrimination. Using daily questionnaires via a smartphone application, we will study in real-time the specific factors that influence substance use by these adults to cope with discrimination-related stress. Our results will reveal the burden of daily discrimination on addiction and the aspects of cultural resilience that can reduce this burden.

PI_NAMEs: HUH, JIMI  (contact)

PROGRAM_OFFICER_NAME: DUNSTON, SHEBA KING

PROJECT_TERMS: Acculturation;Acute;addiction;Address;Adult;adult of color;Adverse effects;Affect;African American;African American population;aged;Alcohols;American;Asian Americans;assessment application;Attention;Black, Indigenous, People of Color;Cellular Phone;Cessation of life;Cigarette;Color;combustible cigarette;Communities;comorbidity;coping;coping mechanism;Coping Skills;COVID-19 pandemic;Data;design;digital;Discrimination;Disparity;Ecological momentary assessment;Electronic cigarette;Electronic Nicotine Delivery Systems;Environment;Ethnic Origin;Etiology;Event;experience;Focus Groups;Future;Gender;hate crimes;Health;health disparity;high risk;Hispanic Americans;Immigration;improved;Individual;Inequity;infection rate;Intercept;intersectionality;Intervention;Life Expectancy;Logistic Regressions;Marijuana;Measurement;Measures;Methods;microaggression;Minority Groups;Modeling;Nature;novel;Outcome;Pacific Islander;Pain;pandemic disease;pandemic impact;Participant;people of color;perceived discrimination;Personal Satisfaction;Persons;Phase;Play;Police;Policies;polysubstance use;Population;post-pandemic;prevent;Process;prospective;psychologic;Public Health;Questionnaires;Race;Racial injustice;racial population;racism;Recovery;recruit;Reporting;Research;resilience;resilience factor;Resources;response;Risk;Role;smartphone application;social;social stress;social stressor;Stress;stress management;stressor;Structural Racism;Subgroup;Substance Addiction;substance use;Testing;theories;Time;Tobacco use;United States;Variant

PROJECT_TITLE: The role of momentary acute discrimination and cultural resilience in polysubstance use among adults from communities of color

STUDY_SECTION: ARM

STUDY_SECTION_NAME: Addiction Risks and Mechanisms Study Section[ARM]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: NEW YORK

ORG_DEPT: PEDIATRICS

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: PROJECT NARRATIVE – Overall The goals of this proposal are to 1) compare immune responses to two of the most promising contemporary HIV vaccination strategies (SOSIP trimer and mRNA) using highly relevant infant and adolescent nonhuman primate models, and 2) define strategies that harness unique aspects of infant immune development to produce protective anti-HIV immune responses, such as broad neutralizing antibodies. This work has strong potential to identify the age group that should be targeted future human clinical vaccine trials in order to provide HIV protection prior to adolescence and provide insight into immune and microbial factors relevant to vaccine design.

PI_NAMEs: DE PARIS, KRISTINA ;PERMAR, SALLIE R. (contact)

PROGRAM_OFFICER_NAME: SINGH, ANJALI

PROJECT_TERMS: Achievement;Adjuvant;Adolescence;Adolescent;Adult;Adult women;Age;age group;Antibodies;Antibody Response;Antibody-mediated protection;Antigens;Autologous;B-Lymphocytes;Biological;Cell Communication;Cell Lineage;Cells;Childhood;Clinical Research;Collaborations;design;Development;Dose;Epidemic;Evolution;Funding;Future;Germ Lines;Goals;HIV;HIV envelope protein;HIV Infections;HIV vaccine;HIV-1;HIV/AIDS;Human;Human Milk;Immune;Immune response;Immune system;Immunity;Immunization;Immunize;immunogenicity;Immunoglobulin Somatic Hypermutation;Immunologics;Immunology;infancy;Infant;Infection;Infrastructure;insight;Life;lipid nanoparticle;Macaca mulatta;Mediating;Messenger RNA;microbial;microbial signature;microbiome;microbiota;microorganism interaction;Modeling;Molecular;Monkeys;mRNA lipid nano particle vaccine;neutralizing antibody;nonhuman primate;novel;Passive Immunization;Pathway interactions;Plasma;Population;preadolescence;preclinical study;predictive signature;prevent;Prevention;programs;Rectum;Regimen;response;Rhesus;Risk Reduction;RNA vaccine;sexual debut;Sexual Transmission;simian human immunodeficiency virus;System;Systems Biology;Target Populations;Testing;Time;transcriptome;transcriptomics;Translations;transmission process;Vaccination;vaccination strategy;vaccine candidate;Vaccine Clinical Trial;Vaccine Design;vaccine immunogenicity;vaccine platform;vaccine response;vaccine strategy;vaccine-induced antibodies;Vaccines;Vertical Disease Transmission;Virus;Work;young adult;Youth

PROJECT_TITLE: Early Life Vaccination to Prevent HIV acquisition during Adolescence


NIH_SPENDING_CATS: Asthma;Infectious Diseases;Lung

ORG_CITY: DENVER

ORG_NAME: NATIONAL JEWISH HEALTH

ORG_STATE: CO

PHR: Project Narrative Our proposal addresses a significant clinical problem of rhinovirus-mediated exacerbation of asthma. By assembling a multidisciplinary team of scientists, we propose to study a new mechanism of lung defense against rhinoviruses in airways of asthma patients. Our research findings obtained from the state-of-the-art experiments will significantly improve our understanding about host defense mechanisms against rhinovirus infection, and likely provide a new opportunity to treat rhinovirus infection in patients with asthma and other diseases.

PI_NAMEs: CHU, HONG W (contact)

PROGRAM_OFFICER_NAME: DONG, GANG

PROJECT_TERMS: Abbreviations;Acute;Address;Air;airway epithelium;airway hyperresponsiveness;airway inflammation;Allergens;Anti-Inflammatory Agents;Anti-viral Agents;Anti-viral Response;Anti-viral Therapy;Asthma;asthma exacerbation;asthmatic;asthmatic patient;Biological Response Modifiers;Cells;chronic infection;Chronic Obstructive Pulmonary Disease;Clinical;Common Cold;CRISPR/Cas technology;cytokine;Data;Disease;Dose;effective therapy;efficacy evaluation;eosinophil;Eotaxin;Epithelial Cells;experimental study;exposed human population;Exposure to;Genes;Goals;healthcare burden;Host Defense Mechanism;Human;IFNAR1 gene;Immune;Impairment;improved;in vivo;Infection;Inflammation;Inflammatory;innovation;Interferon Receptor;Interferon Type II;Interferons;Interleukin-13;Investigation;Knock-out;knockout gene;Knockout Mice;Liquid substance;Lung;Lung Diseases;Measures;Mediating;Molecular Weight;multicatalytic endopeptidase complex;multidisciplinary;Mus;novel;novel strategies;novel therapeutics;Oxidative Stress;Pathologic;Patients;Peptide Hydrolases;Production;Proteins;Pulmonary Inflammation;Pyroglyphidae;Regulation;Research;Resolution;Respiratory Disease;Rhinovirus;Rhinovirus infection;Role;Scientist;Signal Transduction;Slice;STAT1 gene;STAT1 protein;System;T-Lymphocyte;Testing;Tracheobronchial;Viral;Viral Load result;Viral Physiology;Viral Respiratory Tract Infection;Virus;Virus Diseases;Wild Type Mouse;Work

PROJECT_TITLE: Role of immunoproteasome in airway viral infection

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IMM-T(57)R]


NIH_SPENDING_CATS: Behavioral and Social Science;Social Determinants of Health

ORG_CITY: GALVESTON

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

PHR: PROJECT NARRATIVE The University of Texas Medical Branch (UTMB) PREP scholars program, PREPing for SUCCESS, addresses an important national need to increase the number of PhD-level scientists from groups that are underrepresented in the biomedical sciences to enhance the diversity of our research workforce and indicated by a growing body of research to heighten scientific innovation, discovery and global competitiveness. Working closely with partner universities in Texas and beyond, each year we will recruit 8 talented scholars having an aptitude for research to participate in an individually customized and mentored research and skills development program preparing them to enroll in and complete a PhD in the sciences at a top-tier research intensive graduate school.

PI_NAMEs: VARGAS, GRACIE  (contact)

PROGRAM_OFFICER_NAME: AKACEM, LAMEESE DANA

PROJECT_TERMS: Academic skills;Address;Admission activity;African American;Aptitude;Area;Biomedical Research;career;Communities;Complement;Counseling;Creativeness;design;Development;Development Plans;disabled;Disabled Persons;disadvantaged student;Doctor of Philosophy;Economically Deprived Population;Education;Educational Curriculum;Educational workshop;Enrollment;Ethnic Population;Evaluation;experience;Faculty;faculty mentor;family support;flexibility;Fostering;Funding;Goals;graduate school;graduate student;Graduation Rates;hands on research;Health;health disparity;Hispanic;Human;Immunity;Individual;Infection;innovation;interest;Intervention;Laboratories;laboratory experience;Laboratory Research;matriculation;Medical;Mentors;Minority;Mission;Motivation;Native Americans;Outcome;peer coaching;Postbaccalaureate;Postdoctoral Fellow;Program Development;programs;recruit;Research;research and development;Research Personnel;responsible research conduct;Scholars Program;Science;Scientific Advances and Accomplishments;Scientific Inquiry;Scientist;skill acquisition;skills;socioeconomic disadvantage;student training;Students;success;support network;System;Talents;Texas;therapy design;Training;Training Programs;Translational Research;Underrepresented Minority;Underrepresented Populations;Underrepresented Students;Underserved Population;Universities

PROJECT_TITLE: PREPing for SUCCESS

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - D[TWD-D]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cerebrovascular;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Neurodegenerative;Neurosciences;Prevention;Sleep Research;Vascular Contributions to Cognitive Impairment and Dementia (VCID);Women's Health Research

ORG_CITY: ANN ARBOR

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative Approximately 5.7 million Americans have dementia, but treatments to prevent, cure, or slow dementia progression are lacking. Recent research suggests a link between obstructive sleep apnea (OSA) and incident dementia, but this relationship and the potential protective effect of OSA treatment on dementia risk have been insufficiently studied. This study will utilize longitudinal data from a nationally representative, multi-ethnic longitudinal cohort study of older adults, linked with Medicare claims datasets, to examine pathways between OSA, OSA treatment and cognitive decline among women and men.

PI_NAMEs: BRALEY, TIFFANY JOY (contact);DUNIETZ, GALIT LEVI

PROJECT_TERMS: Abeta clearance;Address;Affect;Alleles;Alzheimer's Disease;Alzheimer's disease risk;American;apolipoprotein E-4;Attention;beneficiary;Biological Markers;Cells;clinical practice;Code;Cognition;Cognitive;cognitive function;cohort;cost effective;Coupled;Data;Data Set;Dementia;dementia risk;Development;Diagnosis;Disease;Disease Progression;disparities in women;effective therapy;Evaluation;Event;follow-up;Fostering;Frequencies;Future;Genotype;Goals;Health;Health and Retirement Study;Heterogeneity;Hypoxia;ICD-9;Immune;Immunologic Markers;Impaired cognition;Impairment;improved;Incidence;Individual;Inflammation;Inflammatory;insight;Interleukin-6;Joints;Knowledge;large datasets;Link;Longitudinal cohort;Longitudinal cohort study;Measures;Mediating;Mediator;Medicare;Medicare claim;Memory;men;mild cognitive impairment;Mission;modifiable risk;Morbidity - disease rate;multi-ethnic;Nerve Degeneration;Neurocognitive;Obstructive Sleep Apnea;older adult;older men;Older Population;older women;Outcome;Outcome Measure;Participant;Pathologic;Pathway interactions;Population;Population Study;positive airway pressure;pressure;Prevalence;prevent;Probability;prospective;protective effect;Public Health;randomized, clinical trials;Reporting;Research;Research Personnel;Risk;Risk Factors;Role;sex;Sex Differences;sex disparity;Sleep;Sleep Deprivation;Sleep Disorders;Sleep disturbances;Sleep Fragmentations;therapy adherence;Time;TNF gene;treatment disparity;Vascular Dementia;Woman;Work

PROJECT_TITLE: Pathways between OSA and cognitive decline in older women and men: a longitudinal population-based study

STUDY_SECTION: NAME

STUDY_SECTION_NAME: Neurological, Aging and Musculoskeletal Epidemiology Study Section[NAME]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza;Vector-Borne Diseases

ORG_CITY: LITTLE ROCK

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIV OF ARKANSAS FOR MED SCIS

ORG_STATE: AR

PHR: Narrative Inhalation of the bacterium Yersinia pestis results in pneumonic plague, a highly lethal infection with mortality rates approaching 100%. The proposed work seeks to understand the interaction of Y. pestis with host cells in the lung by characterizing the function of a well-established mediator of pathogenesis in the early events that establish pneumonic plague.

PI_NAMEs: PECHOUS, ROGER D (contact)

PROGRAM_OFFICER_NAME: MUKHOPADHYAY, SUMAN

PROJECT_TERMS: Adherence;Alveolar Macrophages;Attenuated;Bacteria;Bacterial Adhesins;bacterial resistance;cell type;Cells;Data;Death Rate;Disease;Epithelial Cells;Event;Feedback;Flow Cytometry;Fluorescence-Activated Cell Sorting;Growth;Human;Immune;Immune signaling;In Vitro;in vivo;Infection;Inflammation;Inflammatory;Inflammatory Response;Inhalation;innate immune mechanisms;Innate Immune Response;insight;Laboratories;Lung;Lung infections;Maps;Mediating;Mediator;Mus;mutant;neutrophil;Neutrophil Infiltration;novel;pathogen;Pathogenesis;Peptide Hydrolases;Phase;Phosphotransferases;Plague;Plasminogen Activator;Play;Pneumonic Plague;Population;Population Dynamics;prevent;Proteome;Proteomics;Reporter;Research;response;Role;sensor;Surface;Surveys;Symptoms;System;Testing;Time;Tissues;transcriptomics;Virulence Factors;Work;Yersinia;Yersinia pestis

PROJECT_TITLE: Defining the Role of the Plasminogen Activator Protease in the Early Events that Establish Primary Pneumonic Plague

STUDY_SECTION: HIBP

STUDY_SECTION_NAME: Host Interactions with Bacterial Pathogens Study Section[HIBP]


NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative We will study the ubiquitin pathway in human cells and yeast, with an emphasis on identify roles for poorly understood ubiquitin ligases. This work will have a large emphasis on identifying substrates and determining the repercussions of not targeting those substrates.

PI_NAMEs: TOCZYSKI, DAVID PAUL (contact)

PROGRAM_OFFICER_NAME: MACARTHUR, LINDA

PROJECT_TERMS: Affinity;Alkylating Agents;Biological;Biological Process;CDK4 gene;Cell Cycle Progression;Cells;Chemicals;Complex;CRISPR library;CRISPR screen;CUL5 gene;Cytoskeleton;Dedications;DNA Damage;F-Box Proteins;FBXW7 gene;Genes;Genetic;Genetic Screening;Genetic Transcription;genome integrity;Human;Individual;inhibitor;Laboratories;Ligase;Mammalian Cell;Mass Spectrum Analysis;Metabolic Pathway;Methods;Mitochondria;Mitosis;mutant;Nuclear Export;Pathway interactions;Phenotype;Phosphorylation;Post-Translational Protein Processing;Post-Translational Regulation;protein folding;response;RNA Processing;Role;Signal Transduction;Specificity;Stress;System;Translations;Ubiquitin;ubiquitin ligase;Ubiquitination;Work;Yeasts

PROJECT_TITLE: Regulation by post-translation modifications in response to stress

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-D(55)R]


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Clinical Research;Genetics;Hematology;Human Genome;Infectious Diseases;Lung;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Rare Diseases;Sepsis

ORG_CITY: PROVIDENCE

ORG_NAME: RHODE ISLAND HOSPITAL

ORG_STATE: RI

PHR: Project Narrative Despite the use of state-of-the-art supportive care and a variety of novel anti-inflammatory agents in critically ill/injured patients, multiple organ failure continues to be a major cause of morbidity/mortality in the surgical intensive care unit. This study is designed to determine if a family of novel checkpoint proteins, expressed on immune and non-immune cells, can be used to block the development of organ injury in the critically ill patient.

PI_NAMEs: AYALA, ALFRED  (contact)

PROGRAM_OFFICER_NAME: ZHAO, XIAOLI

PROJECT_TERMS: Accounting;Acute Lung Injury;Adoptive Transfer;Age;Animals;Anti-Inflammatory Agents;Apoptosis;Area;ATAC-seq;Automobile Driving;bisulfite;Cause of Death;cecal ligation puncture;Cell surface;Cells;Cessation of life;Clinical Research;comparative;Consensus;Cre-LoxP;Critical Illness;Defect;design;Developed Countries;Development;Endothelium;Epigenetic Process;epigenomics;Epithelial Cells;Etiology;Event;examination questions;Family;Frustration;Genetic;Hemorrhagic Shock;Hospitals;Immune;immune function;Immune system;Immune System Diseases;Immunoglobulin Domain;Immunologic Memory;Incidence;inhibitor;injured;Injury;Intensive Care Units;Intestines;kidney dysfunction;Leukocytes;Ligands;Liver;Lung;Lymphoid Cell;member;microbiota;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;Multiple Organ Failure;Myelogenous;neonatal sepsis;neonate;novel;organ growth;organ injury;Outcome;patient population;Patients;Population;Predisposition;Prognostic Marker;programs;protein expression;Protein Family;Proteins;pyrosequencing;receptor;Reporting;response;Role;SARS-CoV-2 infection;Sepsis;septic;Shock;single-cell RNA sequencing;Supportive care;Suppressor-Effector T-Lymphocytes;Surgical Intensive Care;Survivors;T-Cell Activation;T-Lymphocyte;therapeutic target;transcriptome sequencing;transcriptomics

PROJECT_TITLE: Mechanism of Immune Dysfunction and Morbid Outcomes in Response to Shock/Sepsis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-T(55)R]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Drug Abuse (NIDA only);Mental Health;Neurosciences;Substance Misuse

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE Recent research demonstrates a novel role for midbrain dopamine neurons in model-based learning. Here, we will reveal the model-based function of two non-canonical dopamine circuits, filling gaps in the knowledge of the particular dopamine circuits that are necessary for this model-based decision making. Given substance use disorders (SUDs) are characterized by ill-informed decisions that lack consideration of future consequences, the very essence of model-based decision making, in the longer term this work could lead to novel targets for treating pathological decision making present in SUDs.

PI_NAMEs: SHARPE, MELISSA ;WASSUM, KATE M (contact)

PROGRAM_OFFICER_NAME: NAIR, SUNILA GOPI

PROJECT_TERMS: Adaptive Behaviors;Address;Algorithms;Amygdaloid structure;Automobile Driving;Basic Science;Behavior;Behavior assessment;Behavioral;Brain region;catalyst;cell type;Clinical;Coupled;Cues;Data;Decision Making;Desire for food;Development;Diagnosis;directional cell;Dissection;Distal;Dopamine;dopaminergic neuron;Emotional;Environment;Event;Exposure to;feeding;flexibility;Fright;Functional disorder;Future;Genetic;Goals;Hypothalamic structure;Individual;innovation;interest;Knowledge;Lateral;Learning;Link;Measurement;Mediating;Memory;Mental disorders;Methods;Midbrain structure;model development;Modeling;Modernization;neural;neural circuit;Neural Pathways;Neurobehavioral Manifestations;Neurons;Neurosciences;next generation;novel;optical imaging;Optics;optogenetics;Outcome;Pathologic;Pathway interactions;Phase;Policies;prevent;Process;prospective;Psyche structure;Psychological reinforcement;Research;response;Rewards;Role;sensor;Sensory;Signal Transduction;Stimulus;Structure;Substance Use Disorder;System;Techniques;Testing;theories;tool;Ventral Tegmental Area;Work

PROJECT_TITLE: Contribution of non-canonical dopamine pathways to model-based learning


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Genetics;Macular Degeneration;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: BAR HARBOR

ORG_NAME: JACKSON LABORATORY

ORG_STATE: ME

PHR: PROJECT NARRATIVE/RELEVANCE TO PUBLIC HEALTH  The retinal pigment epithelium (RPE), a cell layer at the back of the eye, is essential for retinal function and normal vision and disruptions of the RPE underlie many heritable retinal diseases and age-related macular degeneration (AMD), the leading cause of blindness in aging western populations. The proposed project will identify therapeutic targets by elucidating pathological pathways disrupted in mouse models of the human disease butterfly macular dystrophy, which shares phenotypic characteristics with a broader range of human RPE-related diseases.

PI_NAMEs: NAGGERT, JUERGEN K. (contact)

PROGRAM_OFFICER_NAME: SHEN, GRACE L

PROJECT_TERMS: absorption;Actins;Affect;Age related macular degeneration;Aging;Alleles;alpha catenin;Area;Back;Binding Proteins;Biochemical;Blindness;Butterflies;Cell Adhesion;Cell Nucleus;Cells;Characteristics;Clinical;Communities;Complex;Computing Methodologies;Cytoskeleton;Defect;Deposition;Disease;disease model;disease phenotype;disorder of macula of retina;druggable target;Elderly;end stage disease;Environmental Risk Factor;Exhibits;Extracellular Matrix;Eye;Functional disorder;gene augmentation therapy;Genes;Genetic;genome wide association study;genomic data;Genomics;Goals;Heritability;Histologic;Homeostasis;Human;human model;Individual;Induced Mutation;inherited retinal degeneration;Ions;Lead;Leber's amaurosis;Lesion;Light;Lipids;macular dystrophy;Maps;mass spectrometric imaging;Measurement;Metabolic;metabolomics;Modeling;Molecular;Morphology;mouse model;Mouse Strains;Mus;mutant;Mutation;novel;Nuclear;Nutrient;Online Mendelian Inheritance In Man;Other Genetics;Pathogenesis;Pathogenicity;Pathologic;Pathology;Pathway interactions;Patients;pattern dystrophies;Phenotype;phenotypic data;phosphoproteomics;Photoreceptors;Pigment Epithelium;Play;Population;pre-clinical;prevent;Process;programs;Proteomics;Public Health;Recycling;Reporting;Research;Resources;Retina;Retinal Defect;Retinal Degeneration;Retinal Diseases;retinal rods;Role;Severities;Shapes;Signal Transduction;structural determinants;Structure of retinal pigment epithelium;Testing;Therapeutic;therapeutic evaluation;therapeutic target;therapy development;Tissues;transcriptomics;Variant;Vision;Vision research;visual cycle;Visual impairment;Water

PROJECT_TITLE: Identifying mechanistic pathways underlying RPE pathogenesis in models of pattern dystrophy

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Genetics

ORG_DEPT: PHARMACOLOGY

PHR: PROJECT NARRATIVE We seek to understand the molecular mechanisms controlling mRNA decapping, the penultimate, irreversible step committing an mRNA to destruction. The expression of thousands of human genes is regulated by the coordinated destruction of messenger RNA which is thought to occur in biological condensates called mRNA processing bodies (P-bodies). The biochemical and structural details provided by this work may pave the way to treat intellectual disability or cancer. More broadly, like mRNA decay, numerous additional biochemical pathways are organized in biological condensates, and the principles of how condensation affects active site geometry are poorly understood. Our proposal will shed light on how the formation of a biological condensate affects enzyme conformation, a critical but poorly understood parameter for the discovery and design of therapies that target enzymes in condensates that are dysregulated during human disease.

PI_NAMEs: GROSS, JOHN D (contact)

PROGRAM_OFFICER_NAME: CZAPLINSKI, KEVIN

PROJECT_TERMS: 7-methylguanosine;Active Sites;Address;Affect;Binding;Binding Sites;Biochemical;Biochemical Pathway;Biochemical Reaction;Biological;Biological Assay;Bypass;C-terminal;Cells;Complex;Conceptions;Coupled;Couples;Cytoplasm;Data;decapping enzyme;Digestion;Dimerization;Disease;Enhancers;enzyme activity;Enzymes;Eukaryota;Excision;Exhibits;Exoribonucleases;Fission Yeast;Fluorescence;Gene Expression;Genes;Geometry;Human;human disease;In Vitro;Intellectual functioning disability;Lesion;Licensing;Liquid substance;Major Core Protein;Malignant Neoplasms;Mediating;Membrane;Messenger RNA;Modeling;Molecular;Molecular Conformation;Molecular Genetics;monomer;mRNA decapping;mRNA Decay;mRNA Transcript Degradation;Multienzyme Complexes;mutant;novel;Organelles;Outcome;Pathway interactions;Phase;Physical condensation;Physiologic pulse;Physiological;Property;Proteins;Publishing;reconstitution;Regulation;Reporting;Repression;RNA Binding;RNA Degradation;Signal Transduction;Structure;targeted treatment;Testing;therapy design;Transcript;Work;Yeasts

PROJECT_TITLE: Molecular Mechanisms that Control mRNA Decapping in Biological Condensates

STUDY_SECTION: MSFC

STUDY_SECTION_NAME: Macromolecular Structure and Function C Study Section[MSFC]


ORG_CITY: CORDOBA

ORG_COUNTRY: ARGENTINA

ORG_FIPS: AR

ORG_NAME: NATIONAL RESEARCH COUNCIL OF ARGENTINA

PHR: PROJECT NARRATIVE - RELEVANCE This project will provide information about the role of early Extrafollicular plasmablast response in the development of protective B and T cell response to Trypanosoma cruzi, the parasite that causes Chagas disease. This initial response of B cells, that start outside the B-cell follicle, responsible of first wave of antibodies and able to produce cytokines and to function as antigen-presenting cell could be key in the outcome of the infection. Results will be of great significance for the identification of new targets aimed at enhancing protective immunity in Chagas disease and other chronic infections which course with strong polyclonal B cell activation and early Extrafollicular plasmablast response.

PI_NAMEs: GRUPPI, ADRIANA  (contact)

PROGRAM_OFFICER_NAME: PESCE, JOHN T

PROJECT_TERMS: Acute;adaptive immunity;Adenosine;Adjuvant;Affect;Affinity;Anatomy;Antibodies;Antibody Affinity;Antibody Formation;Antibody-mediated protection;Antigen Presentation;Antigen-Presenting Cells;Antigens;antimicrobial;Appearance;Autoantibodies;B-Cell Activation;B-Lymphocyte Subsets;B-Lymphocytes;Bacterial Infections;Biological Assay;Bone Marrow;CD8-Positive T-Lymphocytes;CD80 gene;CD86 gene;Cells;Chagas Disease;Characteristics;Chimera organism;Chronic;chronic infection;Clinic;Clinical;Coculture Techniques;Comprehension;conditioning;COVID-19;Cues;cytokine;Cytometry;Data;design;Detection;Development;Disease;Disease Outcome;Disease Progression;economic impact;Enzyme-Linked Immunosorbent Assay;Evaluation;Exhibits;Experimental Models;experimental study;extracellular;Flow Cytometry;Frequencies;Functional disorder;Gene Modified;Generations;Helper-Inducer T-Lymphocyte;Heterogeneity;Humoral Immunities;IgG1;IgG2;IL17 gene;Image;Immune;Immune response;Immunity;Immunofluorescence Immunologic;Immunoglobulin Class Switching;Immunoglobulin G;Immunoglobulin M;Immunoglobulin Somatic Hypermutation;Immunoglobulin Switch Recombination;Immunoglobulin-Secreting Cells;Immunology;immunoregulation;Immunosuppression;improved;In Vitro;in vivo;Infection;Inflammatory;influenzavirus;innovation;Interleukin-6;Knowledge;Latin America;Link;Lymphocyte Activation;Lymphocytic choriomeningitis virus;Measures;Microbe;migration;Modeling;mortality;Mus;Mutant Strains Mice;novel;novel therapeutics;Nucleosides;Outcome;Parasite Control;Parasitemia;Parasites;Parasitic infection;pathogen;Pathogenesis;Pathogenicity;Pathway interactions;Persons;Phase;physically handicapped;Plasmablast;Plasmodium;Play;Population;programmed cell death ligand 1;Public Health;Publishing;Reaction;Regulation;Reporting;response;Role;Salmonella;Side;Signal Transduction;single-cell RNA sequencing;Source;Specificity;Structure of germinal center of lymph node;T cell response;T-Lymphocyte;Testing;therapeutic target;TNF gene;Trypanosoma cruzi;Vaccines;Virus Diseases

PROJECT_TITLE: Antibody-secreting Cells in the Outcome of Trypanosoma cruzi Infection

STUDY_SECTION: PTHE

STUDY_SECTION_NAME: Pathogenic Eukaryotes Study Section[PTHE]


NIH_SPENDING_CATS: Cancer;Colorectal Cancer;Digestive Diseases;Genetics;Nutrition;Obesity;Prevention;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Project Narrative Obesity is associated with increased colorectal cancer incidence and mortality, in part by activation of the Wnt signaling pathway. However, efforts to therapeutically target Wnt signaling have been unsuccessful in the vast majority of colorectal cancers. We found that specific components of the Wnt signaling pathway are highly upregulated in high fat diet-induced obesity, and therefore hypothesize that disrupting this mechanism of Wnt activation will successful treat obesity-associated colorectal cancer.

PI_NAMEs: ROPER, JATIN  (contact)

PROGRAM_OFFICER_NAME: YASSIN, RIHAB R

PROJECT_TERMS: Affect;Agonist;American;APC gene;beta catenin;Biological Assay;Biotechnology;Body mass index;cancer initiation;Cancer Model;cancer stem cell;cancer type;Cells;chromatin immunoprecipitation;Clinical Trials;cohort;Colon;colon cancer patients;colon carcinogenesis;Colon Carcinoma;colon tumorigenesis;Colonic Neoplasms;Colorectal Cancer;colorectal cancer progression;colorectal cancer treatment;Colorectal Neoplasms;CRISPR screen;CRISPR/Cas technology;Data;Development;diet-induced obesity;dietary control;Disease;Family;Genes;Genetic Transcription;Genetically Engineered Mouse;Goals;Guanine Nucleotide Exchange Factors;Guanosine Triphosphate;Guanosine Triphosphate Phosphohydrolases;High Fat Diet;In Vitro;in vivo;Incidence;inhibitor;innovation;Intestinal Cancer;Intestinal Neoplasms;Intestines;KRASG12D;LGR5 gene;loss of function;Maintenance;Malignant Neoplasms;Mediating;member;Metastatic Neoplasm to the Liver;mortality;mortality risk;mouse model;Mus;Nature;Neoplasm Metastasis;novel;novel therapeutic intervention;Nuclear Translocation;obese person;Obesity;Organoids;Patients;Population;PPAR delta;pre-clinical;Prevention strategy;programs;Protocols documentation;Research;restoration;rho;rho GTP-Binding Proteins;Risk Factors;Role;Signal Transduction;single-cell RNA sequencing;stem cell expansion;stem cell function;stem cell proliferation;stem cell self renewal;stem cells;Testing;Therapeutic;therapeutic target;Thinness;Tissue Sample;Transducers;transplant model;Transplantation;treatment strategy;tumor initiation;tumor progression;Tumor Suppressor Genes;tumorigenesis;Weight;WNT Signaling Pathway

PROJECT_TITLE: Wnt signaling in obesity-associated colorectal cancer

STUDY_SECTION: MONC

STUDY_SECTION_NAME: Molecular Oncogenesis Study Section[MONC]


NIH_SPENDING_CATS: Bioengineering;Neurosciences

ORG_DEPT: OTOLARYNGOLOGY

PHR: Project Narrative Mammals hear when the highly-organized organ of Corti vibrates in response to sound pressure waves and stimulates hair cells. Herein, we propose image these vibrations non-invasively and understand how these structures work together to create high auditory sensitivity and sharp frequency tuning. This question remains unsolved and is clinically important because while hearing aids can compensate for the loss of sensitivity, we have no treatments for the loss of frequency tuning.

PI_NAMEs: OGHALAI, JOHN S (contact)

PROGRAM_OFFICER_NAME: CYR, JANET

PROJECT_TERMS: 3-Dimensional;Affect;Air;Anatomy;Anesthesia procedures;Animals;Arousal;Auditory;auditory stimulus;Auditory system;awake;Back;Basic Science;Basilar Membrane;Biomechanics;Biomedical Engineering;Biophysical Process;bone;Brain;capsule;Characteristics;Clinical;Cochlea;Cochlear duct;Compensation;Complex;Data;Dependence;design;Diameter;Environment;experimental study;External auditory canal;Frequencies;Hair Cells;Head;Hearing;Hearing Aids;hearing impairment;Image;in vivo;indexing;innovation;Left;Mammals;Measurement;Measures;Mechanics;Medial;Mediating;Motion;Mus;Optical Coherence Tomography;Optics;Organ of Corti;otoacoustic emission;Outer Hair Cells;Painless;peer;Physiology;pressure;Process;Production;Pupil;Reflex action;Research Project Grants;Resolution;response;restraint;Role;sound;Speech;stem;Structure;Supporting Cell;System;Technology;tectorial membrane;Testing;Time;Travel;treadmill;vector;vibration;Walking;walking speed;Wild Type Mouse;Work

PROJECT_TITLE: Cochlear mechanics in the mouse

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Kidney Disease;Liver Disease;Prevention

PHR: PROJECT NARRATIVE The burden of kidney dysfunction in cirrhosis patients continues to increase; however, the tools we employ to identify a patient’s risk for acute kidney injury are limited. This proposal—through the use of a large longitudinal cohort and novel biomarkers—aims to earlier identify cirrhosis patients at risk for AKI in an effort to implement preventative strategies and reduce kidney-related morbidity and mortality.

PI_NAMEs: CULLARO, GIUSEPPE  (contact)

PROGRAM_OFFICER_NAME: GREER, RAQUEL CHARLES

PROJECT_TERMS: Acceleration;Acute Renal Failure with Renal Papillary Necrosis;Address;Adult;Affect;Age;aging population;Albumins;American;Award;Biological Markers;Biological Specimen Banks;biomarker driven;biomarker selection;biomarker validation;Biometry;Calibration;California;career;career development;Cause of Death;Cessation of life;Chronic Kidney Failure;Cirrhosis;Clinical;clinical predictors;Clinical Research;clinical risk;cohort;Collaborations;Communities;Complication;cost;Coupled;Creatine;Creatinine;Data;Data Analyses;demographics;Development;Development Plans;Discrimination;Early identification;Early Intervention;Enrollment;Equation;Etiology;Evaluation;Fibrosis;Filtration;Foundations;Future;Globulins;Glomerular Filtration Rate;Goals;Health;hemodynamics;Hepatic;Hepatology;Hospitalization;Hour;Impairment;implementation intervention;Incidence;Inflammation;Injury;Injury to Kidney;Inpatients;K-Series Research Career Programs;Kidney;kidney dysfunction;Laboratories;Lead;Leadership;Learning;Liver diseases;liver transplantation;Longitudinal cohort;Machine Learning;Measurement;Measures;Methodology;Methods;Modeling;Morbidity - disease rate;mortality;multidisciplinary;National Institute of Diabetes and Digestive and Kidney Diseases;Nephrology;Nephrons;non-alcoholic fatty liver disease;novel;novel marker;Outcome;Patient risk;Patients;Permeability;Population;post gamma-globulins;predictive tools;Prevalence;prevent;Prevention strategy;Preventive therapy;proenkephalin;programs;Property;Publications;rat KIM-1 protein;Renal function;Research;Research Personnel;Risk;risk prediction;risk stratification;San Francisco;Serum;Severities;Skeletal Muscle;skills;Statistical Data Interpretation;statistics;Structure;Supervision;support vector machine;Techniques;tool;Training;trend;United States;Universities;Urokinase Plasminogen Activator Receptor

PROJECT_TITLE: Application of Novel Biomarkers of Renal Health in Cirrhosis Patients to Stratify Risk of Acute Kidney Injury Occurrence and Reversibility

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK(M1)-1-D]


NIH_SPENDING_CATS: Biotechnology;HIV/AIDS

ORG_CITY: WASHINGTON

ORG_NAME: GEORGE WASHINGTON UNIVERSITY

ORG_STATE: DC

PHR: NARRATIVE There is a clear association between the neutralization sensitivity of virus and how effective bNAbs are in suppressing virus replication during clinical trials; however, there are two main obstacles that limit the use of this assay: length of assay time and difficulty in obtaining the correct samples to test. We propose an ultra-sensitive Env binding assay whose results will correlate to neutralization assay results but will take hours, and that can directly measure translationally competent virus directly in cells lysates, increasing the sampling depth. Our multi- disciplinary team has all the expertise necessary to achieve these aims that, when completed, result in an ultra- sensitive binding assay for Env protein to screen clinical trial participants that is time efficient, accurate and qualified.

PI_NAMEs: BOSQUE, ALBERTO ;LYNCH, REBECCA MARIE (contact)

PROGRAM_OFFICER_NAME: JANCI, ELIZABETH WONDERLICH

PROJECT_TERMS: Address;Aliquot;Antibodies;antibody detection;Binding;Biological;Biological Assay;Cells;CLIA certified;clinical development;clinical efficacy;clinical predictors;clinical trial participant;Clinical Trials;clinically relevant;Cloning;Combined Modality Therapy;Consumption;Data;Detection;detection assay;detector;Documentation;Enrollment;env Gene Products;env Genes;Epitopes;Equipment;gag Gene Products;HIV;HIV Antibodies;HIV-1;Hour;Immunotherapy;improved;In Vitro;Individual;Infusion procedures;Length;Measurement;Measures;Methodology;Methods;Minority;multidisciplinary;Nature;neutralizing antibody;novel;Participant;Performance;Peripheral Blood Mononuclear Cell;Persons;Phase;Phenotype;Plasma;Proviruses;Publishing;Qualifying;Quality Control;Reagent;Reporting;Resistance;resistant strain;Sampling;screening;Signal Transduction;Specific qualifier value;System;Technology;Testing;Therapeutic;Time;treatment strategy;Variant;Viral;Virion;Virus;Virus Replication

PROJECT_TITLE: Ultrasensitive Env Detection Assay for Broadly Neutralizing Antibody Screening


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Dental, Oral, and Craniofacial Disease;Infectious Diseases;Rare Diseases

ORG_CITY: MINNEAPOLIS

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Human T-cell leukemia virus type 1 (HTLV-1) is a cancer-causing human retrovirus that infects about 15-20 million individuals worldwide. While virus particle assembly at cell-cell contacts are required for efficient virus transmission (both within and between individuals), many fundamental aspects involved in this critical mode of virus spread are poorly understood, including the nature of virus spread and particle morphology of released particles. Development of experimental workflows to enable new cutting-edge technologies will improve understanding of this distinct mode of virus transmission, which has broad relevance to other viruses capable of spread via cell-cell contacts – including transmission events

PI_NAMEs: MANSKY, LOUIS M. (contact)

PROGRAM_OFFICER_NAME: MCNEALY, TAMARA L

PROJECT_TERMS: 2019-nCoV;Address;Adult T-Cell Leukemia/Lymphoma;Behavior;Biogenesis;Biomedical Engineering;Capsid;Cell Communication;Cell Culture Techniques;Cells;Cellular biology;Cryoelectron Microscopy;Development;Disease;Electron Microscope;Electron Microscopy;Engineering;Etiology;Event;experimental study;Eye;fluorescence imaging;Fluorescence Microscopy;Goals;high resolution imaging;Human;Human Characteristics;human imaging;Human T-Cell Leukemia Viruses;Human T-lymphotropic virus 1;Image;imaging study;Imaging technology;improved;Individual;Infection;Inflammatory;insight;instrument;Knowledge;Lasers;light microscopy;live cell imaging;Malignant Neoplasms;microscopic imaging;Morphology;mutant;Nature;new technology;novel;Oral;Organ;particle;Pattern;permissiveness;Preparation;Proteins;Pulmonary Pathology;quantitative imaging;Reproducibility;Research;Resolution;Retroviridae;Role;Sampling;Skin;Spinal Cord Diseases;success;superresolution microscopy;Syndrome;Technology;Testing;Thyroid Gland;Tissues;transmission process;Tropical Spastic Paraparesis;Viral;viral transmission;Virion;virological synapse;virology;Virus;Virus Assembly;Virus Diseases;Virus Replication

PROJECT_TITLE: Imaging of HTLV-1 by cryo-CLEM

STUDY_SECTION: VIRA

STUDY_SECTION_NAME: Virology - A Study Section[VIRA]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cardiovascular;Cerebrovascular;Dementia;Hypertension;Neurodegenerative;Neurosciences;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: ITHACA

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: CORNELL UNIVERSITY

PHR: NARRATIVE Blood flow in brain of Alzheimer’s disease mice and patients is reduced relative to healthy counterparts. In Alzheimer’s disease mice, increasing brain blood flow leads to rapid improvements in memory performance. This grant examines the changes in brain tissue oxygenation, cellular metabolism, and neural activity that underlie improved performance on short term memory tasks observed after increasing cerebral blood flow.

PI_NAMEs: SCHAFFER, CHRIS B (contact)

PROGRAM_OFFICER_NAME: NEWMAN, ELIZABETH

PROJECT_TERMS: Acceleration;Address;Aftercare;Age;Alleles;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease related dementia;Amyloid beta-Protein;Amyloid beta-Protein Precursor;Animals;Antibodies;Apolipoprotein E;apolipoprotein E-4;Behavior;Biological Markers;Blood;Blood capillaries;Blood flow;Blood Vessels;Brain;brain dysfunction;brain metabolism;Brain Pathology;brain tissue;cardiovascular risk factor;Cardiovascular system;cell injury;Cell Physiology;Cellular Metabolic Process;cerebral capillary;Cerebrovascular Circulation;Cerebrum;Cessation of life;cognitive function;cognitive recovery;dementia risk;Dependence;Disease;Disease Progression;Drops;Electrodes;Electrophysiology (science);excitatory neuron;Exhibits;functional outcomes;Future;Genes;Genetic Models;genetic risk factor;Goals;Grant;Hippocampus;Hour;Human;Hyperactivity;Hypertension;hypertensive;Hypoxia;Impaired cognition;improved;in vivo calcium imaging;Incidence;inhibitory neuron;Injections;insight;Investigation;Label;Link;Measurement;Measures;Memory;memory consolidation;Memory impairment;Metabolic;metabolic rate;Metabolism;middle age;Modeling;mouse model;Mus;Nerve Degeneration;neural;neural circuit;neural network;Neurobehavioral Manifestations;Neurodegenerative Disorders;neuronal patterning;Neurons;Neurophysiology - biologic function;neutrophil;Nutrient;Obstruction;Optics;Oxygen;Pathogenicity;Pathologic Processes;Patients;Pattern;Performance;Perfusion;Platelet Inhibitors;Predictive Factor;Process;Protein Overexpression;Proteins;Receptor Cell;Recovery;Recovery of Function;Research Personnel;response;restoration;Secondary to;Severities;sex;Short-Term Memory;Silicon;spatial memory;Speed;Stimulus;stressor;Stroke;Symptoms;Techniques;Testing;Therapeutic;Time;tissue oxygenation;Tissues;vascular risk factor;Viral;Visual Cortex;Wild Type Mouse;Work

PROJECT_TITLE: Metabolic and neural activity normalization by cerebral blood flow increase in AD/ADRD models


ED_INST_TYPE: OTHER SPECIALIZED SCHOOLS

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: Princeton

ORG_DEPT: MISCELLANEOUS

ORG_NAME: PRINCETON UNIVERSITY

ORG_STATE: NJ

PHR: Project Narrative: Vibrio cholerae is an important human pathogen whose curved cell shape is important for its pathogenesis, and we previously identified the first two curvature determinants in Vibrio cholerae, CrvA and CrvB. CrvA and CrvB assemble in the cell periplasm into a higher-order structure that promotes curvature; here we propose to determine how CrvA and CrvB assemble with one another, how they interact with the cell wall and other factors to curve V. cholerae, and how curved shapes affect important bacterial behaviors like motility, biofilm interactions, and surface interactions. Together these studies will provide fundamental new insights into how bacterial proteins form copolymers, how periplasmic structures assemble, how curved cell shapes are generated, and the selective benefits that such shapes confer.

PI_NAMEs: GITAI, ZEMER  (contact)

PROGRAM_OFFICER_NAME: RIGAS, MARC

PROJECT_TERMS: Address;Affect;Agar;Bacteria;Bacterial Proteins;Behavior;Behavioral;Binding;Biochemical;Biological Models;Biophysics;Caulobacter crescentus;cell behavior;Cell Physiology;Cell Shape;Cell Wall;Cells;Cellular biology;cellular imaging;Characteristics;copolymer;Cryoelectron Microscopy;Cytoplasm;Cytoskeleton;Defect;Distant;Electron Microscopy;Elements;Energy-Generating Resources;Engineering;Environment;Enzymes;Escherichia coli;experimental study;Face;Fluorescence Microscopy;follow-up;Gel;Geometry;Growth;Guanosine Triphosphate;Higher Order Chromatin Structure;human pathogen;Impairment;In Vitro;in vivo;insight;Intestines;Knowledge;Learning;Mediating;Microbial Biofilms;Microbiology;Molecular;molecular scale;Morphogenesis;Motility;Mucous body substance;Mucous Membrane;Mus;Mutagenesis;mutant;Nature;pathogen;Pathogenesis;Pattern;periplasm;Periplasmic Proteins;polymerization;Polymers;Process;Proteins;Pseudomonas aeruginosa;Reporting;Rhizobium radiobacter;Rod;Role;screening;self assembly;Shapes;Structure;Surface;System;tool;Total Internal Reflection Fluorescent;Vibrio;Vibrio cholerae;Work

PROJECT_TITLE: Formation and function of cell curvature in Vibrio cholerae

STUDY_SECTION: PCMB

STUDY_SECTION_NAME: Prokaryotic Cell and Molecular Biology Study Section[PCMB]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Services;Patient Safety;Prevention

ORG_CITY: MADISON

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE The growing aging population increasingly requires major surgery, often resulting in serious complications, functional impairment, cognitive decline, increases in healthcare utilization and death, which are all major public health burdens. Improving perioperative practices to care for this vulnerable, complex population can reduce this burden. The proposed work will utilize a novel approach to surgical care of older adults, applying systems engineering and implementation science principles to develop an implementation package for preoperative geriatric assessments that can be adapted and applied to a wide range of hospitals, serving a diverse population of older adults.

PI_NAMEs: BERIAN, JULIA ROSE (contact)

PROGRAM_OFFICER_NAME: BAKOS, ALEXIS DIANE

PROJECT_TERMS: Abdomen;Aging;aging population;American;American College of Surgeons;Behavior Therapy;behavioral and social science;care delivery;care providers;career development;Caring;Cessation of life;Clinical;clinical care;Clinical Trials;Cognition;Communities;community setting;Complex;Conduct Clinical Trials;Consensus;contextual factors;Data;design;Development;Dissemination and Implementation;Effectiveness;effectiveness clinical trial;effectiveness-implementation RCT;effectiveness/implementation hybrid;effectiveness/implementation trial;Elderly;Engineering;Environment;Equity;evidence base;experience;Eye;Fellowship;Focus Groups;Functional impairment;Future;Geriatric Assessment;Goals;Guidelines;health care service utilization;health care settings;Health Professional;Health protection;Health Services Research;Health system;Healthcare;Hospitals;Impaired cognition;implementation design;implementation evaluation;implementation intervention;implementation science;implementation strategy;implementation study;implementation trial;improved;improved outcome;Incentives;innovation;Institution;Intervention;intervention delivery;Interview;Knowledge;Length of Stay;Literature;Maps;Measures;meetings;Mental Health;Mentored Patient-Oriented Research Career Development Award;Mentors;Methodology;Methods;Minority;Modeling;Morbidity - disease rate;mortality;Multi-Institutional Clinical Trial;multiple chronic conditions;Muscle;National Institute on Aging;novel;novel strategies;nutrition;older adult;older patient;Operative Surgical Procedures;patient oriented;patient safety;Patient-Focused Outcomes;Patients;Perioperative;Physical Function;pilot test;Polypharmacy;Population;Population Heterogeneity;Positioning Attribute;Postoperative Complications;Postoperative Period;Practice Guidelines;Preparation;preservation;prevent;Process Assessment;programs;Public Health;Quality of Care;Race;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;Recovery of Function;Research;Resources;Risk;Risk Reduction;Rural;Site;skills;social;Strategic vision;surgical service;Surgical Specialties;symposium;System;Testing;tool;Training;Underrepresented Populations;United States National Institutes of Health;uptake;Vulnerable Populations;women versus men;Work

PROJECT_TITLE: Preparing older adults for major abdominal surgery: a systems engineering approach to implement preoperative comprehensive geriatric assessments

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development for Clinicians/Health Professionals Study Section [AGCD-3]


NIH_SPENDING_CATS: Chronic Pain;Interstitial Cystitis;Mental Health;Neurosciences;Pain Research;Urologic Diseases

ORG_CITY: SAINT LOUIS

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

PHR: Narrative This proposal seeks to identify changes in the brain that are lead to the development of pain, urinary urgency, and comorbid anxiety and depression that are very often observed in patients with interstitial cystitis/bladder pain syndrome (IC/BPS). IC/BPS is a serious and painful condition that affects 3-6% of women in the United States. Understanding alterations in brain circuits can help us to design new treatments for IC/BPS.

PI_NAMEs: GEREAU, ROBERT W (contact)

PROGRAM_OFFICER_NAME: MULLINS, CHRISTOPHER V

PROJECT_TERMS: Abdomen;Affect;Affective;Amygdaloid structure;Analgesics;Anatomy;Animals;antinociception;Anxiety;Behavior;Bladder;bladder pain;Brain;Cell Nucleus;Central Lateral Nucleus;Central Medial Thalamic Nucleus;central sensitization;Chronic;Clinical;comorbidity;Cyclophosphamide;Cystitis;design;Development;Disease;effective therapy;Etiology;Functional disorder;Functional Imaging;Funding;generalized anxiety;Genetic;Hyperalgesia;Hypersensitivity;imaging study;In Situ Hybridization;in vivo;Incidence;Increased frequency of micturition;Injury;insight;Interstitial Cystitis;Label;Lead;Maintenance;Maps;Mediating;Mental Depression;micturition urgency;Modeling;Mood Disorders;mouse model;Mus;negative affect;neural circuit;neuronal circuitry;Neurons;Neurosciences;Nociception;Nociceptors;Output;Pain;Patch-Clamp Techniques;Pathologic;Pathology;Patients;Persistent pain;pharmacologic;Physiology;Play;Population;pre-clinical;Prevalence;Process;Property;Quality of life;Regulation;Reporting;Resolution;response;Rodent;Role;segregation;sensory stimulus;Series;single nucleus RNA-sequencing;Slice;Symptoms;System;Testing;transcriptomics;United States;Woman;Work

PROJECT_TITLE: CNS Mechanisms of IC/BPS

STUDY_SECTION: KUFD

STUDY_SECTION_NAME: Kidney and Urological Systems Function and Dysfunction Study Section[KUFD]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Congenital Structural Anomalies;Eye Disease and Disorders of Vision;Gene Therapy;Genetics;Nanotechnology;Neurosciences;Orphan Drug;Pediatric;Rare Diseases

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF HOUSTON

PHR: PROJECT NARRATIVE We aim to expand the benefits of ocular gene therapy for RPE65-associated LCA by using a non-viral gene therapy platform to ensure long-term, physiologically-relevant levels of gene expression. Our platform enables sustained, controlled delivery of the entire therapeutic gene (including regulatory elements). We will validate this platform in RPE65-/- model of LCA, making these studies highly translationally relevant.

PI_NAMEs: NAASH, MUNA I. (contact)

PROGRAM_OFFICER_NAME: NEUHOLD, LISA

PROJECT_TERMS: adeno-associated viral vector;Affect;Biochemical;Blindness;Cells;cis acting element;Clinical;clinical application;Clinical Trials;Cloning;Cone;Cytomegalovirus Infections;cytotoxic;delivery vehicle;Dependovirus;design;Disease;disease phenotype;Distal;DNA;early childhood;Early treatment;efficacious treatment;efficacy evaluation;Elements;Engineering;Enhancers;Ensure;Equilibrium;Equipment;Exons;experience;experimental study;expression vector;extracellular;Eye;Gene Delivery;Gene Expression;Gene Expression Regulation;gene therapy;Gene Transduction Agent;Genes;Genetic;Genomic DNA;Genomics;Goals;Hereditary Disease;High Prevalence;Housing;Human;Human Cloning;improved;in vivo;Inherited;Injections;innovation;Introns;Leber's amaurosis;Longevity;Matrix Attachment Regions;Mediating;Methodology;Methods;Modeling;Molecular Biology;mouse model;Mus;nanoparticle;non-viral gene therapy;novel;Onset of illness;Outcome;Outcome Measure;Papio;Parents;Peptides;Phenotype;Physiological;Polyethylene Glycols;Polylysine;Positioning Attribute;preservation;promoter;Quantitative Reverse Transcriptase PCR;Regulation;Regulatory Element;Research;Resources;Retina;Retinal Diseases;Retinal gene therapy;Retinitis Pigmentosa;Rod;RPE65 protein;scaffold;Structure;Structure of retinal pigment epithelium;targeted treatment;Testing;Therapeutic;therapeutic gene;therapeutically effective;therapy development;tool;Toxic effect;Transcript;transduction efficiency;transgene expression;translational impact;Translations;Treatment Efficacy;Untranslated Regions;Untranslated RNA;uptake;vector;Viral;Vision;Visual;Western Blotting

PROJECT_TITLE: Vector engineering for non-viral delivery of large genomic DNA to the RPE

STUDY_SECTION: GDD

STUDY_SECTION_NAME: Gene and Drug Delivery Systems Study Section[GDD]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Congenital Structural Anomalies;Genetics;Nanotechnology;Orphan Drug;Pediatric;Prevention;Rare Diseases

ORG_CITY: CLEMSON

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: CLEMSON UNIVERSITY

ORG_STATE: SC

PHR: Project Narrative: Aneurysms are an often asymptomatic, pathological, progressive ballooning of a blood vessel and are life-threatening when present in the aorta, the largest artery in the human body. The underlying cause (e.g., connective tissue disorders) and location (i.e., thoracic or abdominal) of aortic aneurysms are diverse, and interventional surgical repairs are complicated and not without adverse events. Therefore, we are developing a universal, non-invasive, systemic, injectable therapy that targets aneurysms with nanoparticles capable of delivering drugs that regress and repair the diseased tissue to obviate surgical intervention and improve the quality of life for patients.

PI_NAMEs: VYAVAHARE, NAREN R (contact)

PROGRAM_OFFICER_NAME: DANTHI, NARASIMHAN

PROJECT_TERMS: Abdomen;abdominal aorta;Abdominal Aortic Aneurysm;Adverse event;adverse outcome;Age Months;Albumins;Aneurysm;Angiotensin II;Animal Model;Anti-Inflammatory Agents;Antibodies;Anxiety;Aorta;Aortic Aneurysm;Aortic Rupture;Apolipoprotein E;Area;Arteries;Atherosclerosis;beta Aminopropionitrile;Blood Vessels;calcification;Cardiovascular system;Cells;Cessation of life;Chest;Clinical;clinically relevant;Collagen;Collagen Fiber;collagenase;Connective Tissue;Connective Tissue Diseases;Data;Defect;Degenerative Disorder;Deposition;Detection;Deterioration;Diagnosis;Disease;Dissection;DNA Sequence Alteration;drinking water;early onset;Ehlers-Danlos Syndrome;Elastases;Elastic Fiber;Elasticity;Elastin;Elective Surgical Procedures;Etiology;Experimental Models;Exposure to;Extracellular Matrix;Extracellular Matrix Degradation;Family suidae;FBN1;Female;Funding;Genes;Genetic;Genetic Diseases;Glucose;Growth;heritable connective tissue disorder;Homeostasis;Homozygote;Human;Human body;Hypertension;improved;individual patient;Infection;Inflammation;Inflammatory;Inflammatory Infiltrate;inflammatory marker;Infusion procedures;Inherited;Injectable;Injections;Intraperitoneal Injections;Life;Location;male;Marfan Syndrome;Matrix Metalloproteinases;Medial;Mediating;Methods;Modeling;Modification;mortality;mouse model;Mus;Mutation;Names;nanoparticle;nanoparticle delivery;Natural regeneration;neutralizing antibody;novel;Operative Surgical Procedures;Pathologic;Patient observation;Patients;Peptide Hydrolases;Pharmaceutical Preparations;pharmacologic;Pharmacological Treatment;polyphenol;porcine model;pre-clinical;prevent;Principal Investigator;programs;Progress Reports;Protein-Lysine 6-Oxidase;Publishing;Pump;Quality of life;Rattus;Recommendation;regeneration potential;repaired;Residual state;response;Risk;Risk Factors;Rupture;Ruptured Abdominal Aortic Aneurysm;Ruptured Aneurysm;Ruptured Aortic Aneurysms;screening;Smoking;success;System;targeted treatment;Testing;therapeutic nanoparticles;Thoracic aorta;Thoracic Aortic Aneurysm;Tissues;Tobacco smoking behavior;Transforming Growth Factor beta;Translating;traumatic event;Unnecessary Surgery;Work

PROJECT_TITLE: Targeted therapy to reverse aortic aneurysms

STUDY_SECTION: AVI

STUDY_SECTION_NAME: Atherosclerosis and Vascular Inflammation Study Section[AVI]


ORG_DEPT: PATHOLOGY

PHR: Project Narrative This project will delineate the cellular mechanisms by which chromosomal rearrangements are formed during the cell cycle by testing the hypothesis that recently discovered modes of DNA replication and repair active in mitosis are responsible for creating many new variant junctions. It will initially focus on fragile loci in the human genome and extend results to the whole genome in cancer relevant mutants. Outcomes will be relevant to public health and NIH's mission by contributing to fundamental knowledge about the mechanisms and stresses that preserve and alter human genetic information, which are the underlying causes of many human genetic diseases.

PI_NAMEs: GLOVER, THOMAS W;WILSON, THOMAS EDWARD (contact)

PROGRAM_OFFICER_NAME: MACARTHUR, LINDA

PROJECT_TERMS: Automobile Driving;Biological Models;BRCA2 gene;Cell Culture Techniques;Cell Cycle;Cell Cycle Stage;Cell Fraction;Cell Lineage;Cells;Chemicals;Chromosomal Rearrangement;Chromosome Fragile Sites;Copy Number Polymorphism;CRISPR/Cas technology;Data;Dedications;DNA;DNA biosynthesis;DNA Repair;DNA Repair Pathway;DNA Synthesis Inhibition;Double Strand Break Repair;Event;Failure;FANCD2 protein;Frequencies;Functional disorder;Genes;Genetic Diseases;genetic information;Genetic Transcription;Genome;genome-wide;Genomic approach;genomic locus;Genomic Segment;Genomics;Germ Lines;Germ-Line Mutation;Goals;Hereditary Disease;Heritability;Human;Human Genetics;Human Genome;insight;Knock-out;Knowledge;Link;Literature;Malignant Neoplasms;Mediating;Meiosis;Methods;Mission;Mitosis;Mitotic;Mitotic M Phase;Modeling;Molecular;Monitor;Mutagenesis;mutant;Mutation;novel;Outcome;Pathway interactions;Pattern;preservation;prevent;Public Health;RAD52 gene;replication stress;Reporting;Resolution;response;Risk;Role;S phase;Sampling;small hairpin RNA;Small Interfering RNA;Sorting;stem cells;Stress;System;Technology;Testing;Time;Tissues;transmission process;United States National Institutes of Health;Variant;whole genome;Work

PROJECT_TITLE: Cell cycle timing and molecular mechanisms of structural variant formation following incomplete replication

STUDY_SECTION: MG

STUDY_SECTION_NAME: Molecular Genetics Study Section[MG]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Kidney Disease;Organ Transplantation;Transplantation

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: PROJECT NARRATIVE Kidney transplantation provides the best survival and quality of life for patients with kidney failure, but there is a shortage of kidneys available for transplantation in the United States. This organ shortage necessitates the use of some deceased donor kidneys with less-than-ideal characteristics, and the safe use of these kidneys requires accurate and reliable assessments of organ quality; however, the current presentation of clinical data leads to suboptimal decision making that discourages the use of transplantable marginal kidneys. This project aims to use decision making science to improve the way that this data is presented, starting with deceased donor kidney biopsy results, in order to improve the utilization of kidneys from the expanded donor and organ pool.

PI_NAMEs: HUSAIN, SYED ALI (contact)

PROJECT_TERMS: Accident and Emergency department;Area;Biopsy;Characteristics;Chest Pain;Clinical;Clinical Data;Cognitive;cognitive load;cohort;Communities;Consumption;cost comparison;cost effective treatment;Coupled;Data;data standards;data visualization;Decision Making;design;Development;Dialysis procedure;Digit structure;discounting;End stage renal failure;Epidemiology;Evaluation;Federal Government;Frequencies;Goals;Grant;heuristics;Histologic;human centered design;improved;Intervention Studies;Kidney;kidney biopsy;Kidney Failure;Kidney Transplantation;Label;Left;Maintenance;Mentors;multidisciplinary;Nephrosclerosis;Organ;organ allocation;organ procurement transplantation network;Organ Procurements;Outcome;Patients;Pattern;Perception;post-transplant;pressure;prognostic;Prospective Studies;Quality of life;randomized trial;Recording of previous events;Recovery;Reporting;Research;research data dissemination;Research Design;Research Personnel;response;Risk;satisfaction;Scheme;Science;skill acquisition;Standardization;Structure;Surgeon;Testing;Time;trait;transplant centers;Transplant Surgeon;Transplantation;Triage;United States;usability;Wait Time;Work

PROJECT_TITLE: Using Decision Making Science to Optimize Deceased Donor Kidney Allocation


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Aging;Biotechnology;Clinical Research;Diabetes;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Nutrition;Osteoporosis;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: PROJECT NARRATIVE Osteoporosis, associated fragility fracture, and type 2 diabetes (T2D) are major public health problems that disproportionately influence older Hispanic/Latino (H/L) populations. Using the integrative analysis of genetic and transcriptomic findings, the proposed study will identify causal pathways between T2D and metabolic risk and skeletal health among Mexican Americans, an understudied population. This study will offer better insights into skeletal health disparities in older H/L adults at risk for T2D to develop targeted interventions.

PI_NAMEs: LEE, MIRYOUNG  (contact);RIANON, NAHID J.

PROGRAM_OFFICER_NAME: JOSEPH, LYNDON

PROJECT_TERMS: Acceleration;Address;Adult;Age;aged;Aging;Black race;bone;Bone Density;bone health;bone loss;bone quality;bone turnover;causal variant;Clinical;cohort;Cohort Studies;County;Cross-Sectional Studies;Data;Deterioration;Diabetes Mellitus;differential expression;Dual-Energy X-Ray Absorptiometry;Epidemiology;Female;Femur;follow-up;Fracture;fracture risk;fragility fracture;Gene Expression;General Population;Genetic;genetic analysis;Genetic Risk;genetic risk factor;Genetic study;Genetic Variation;genome wide association study;genomic locus;Genomics;Glean;Goals;Health;health disparity;High Prevalence;high risk;Hispanic;Hispanic Populations;Image;Individual;innovation;insight;Intervention;Knowledge;Latino;Latino Population;longitudinal design;Low income;low socioeconomic status;Maps;Measures;Mediating;Mendelian randomization;Metabolic;Metabolic Bone Diseases;Metabolic dysfunction;Metabolic Pathway;Methods;Mexican Americans;Mexico;Minority Groups;Monitor;Neck;non-diabetic;Non-Insulin-Dependent Diabetes Mellitus;Not Hispanic or Latino;novel;Obesity;older adult;Older Population;Osteoporosis;Participant;Pathway interactions;Patients;Pattern;Persons;Phenotype;phenotypic data;Population;population based;Predisposing Factor;premature;Prevention;Public Health;Radiology Specialty;Reporting;Research;Risk;Risk Assessment;Risk Factors;risk variant;Role;Sampling;skeletal;Subgroup;Thinness;Time;tool;Trabecular Bone Score;trait;transcriptome sequencing;transcriptomics;United States;Vertebral column;Visit

PROJECT_TITLE: Genomic, transcriptomic, and metabolic effects on skeletal health in Mexican Americans

STUDY_SECTION: AIMR

STUDY_SECTION_NAME:
Aging, Injury, Musculoskeletal, and Rheumatologic Disorders Study
Section[AIMR]


NIH_SPENDING_CATS: Nutrition;Obesity

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE Millions of people suffer from loss of muscle protein that causes substantial health risks, including fractures and metabolic disease, but pharmacological therapies are not currently available to effectively mitigate muscle atrophy without rendering substantial side effects. Adipose tissue is an endocrine organ that responds to energetic challenges by secreting signaling proteins, which play critical roles in systemic energy metabolism and can be developed into therapeutic targets for treating metabolic diseases. This proposal aims to establish a novel mechanism of adipose-muscle crosstalk mediated by a hormone that promotes protein synthesis that has potential future therapeutic implications as a treatment for muscle atrophy.

PI_NAMEs: ZHAO, MENG  (contact)

PROGRAM_OFFICER_NAME: LINDHURST, MARJORIE JEAN

PROJECT_TERMS: Ablation;Acute;Adipocytes;adipokines;Adipose tissue;Atrophic;Biochemistry;Bioinformatics;bioinformatics tool;Biological Assay;Biology;career;career development;Chronic;Clustered Regularly Interspaced Short Palindromic Repeats;Conceptions;Data;Degradation Pathway;Development Plans;Diabetes Mellitus;Disease;Endocrine;Endocrine Glands;Endocrinologist;Endocrinology;Energy Metabolism;Environment;Enzyme-Linked Immunosorbent Assay;Equilibrium;Exercise;experimental study;Fiber;Fibroblasts;Fracture;FRAP1 gene;Future;Genes;Genetic;Genetic Transcription;glucose uptake;Goals;Growth;Health;Hormonal;Hormones;Human;improved;In Vitro;in vivo;innovation;insight;Insulin Resistance;Knock-in;Knockout Mice;Liver;Maps;Mediating;Mentors;Metabolic;Metabolic Diseases;Morbidity - disease rate;mouse model;Mus;Muscle;Muscle Cells;Muscle Fibers;muscle form;Muscle function;muscle physiology;Muscle Proteins;Muscular Atrophy;novel;Nutrient;Obesity;Organ;Pathologic;Pathway interactions;Persons;pharmacologic;Pharmacological Treatment;phosphoproteomics;Phosphorylation;Physiological;Physiology;PIK3CG gene;Play;Point Mutation;Postdoctoral Fellow;protein biomarkers;Protein Biosynthesis;protein degradation;Protein Secretion;Protein Synthesis Induction;Proteins;proteostasis;Proto-Oncogene Proteins c-akt;Publications;receptor;Regulation;Research;research and development;Research Personnel;Research Training;response;Risk;Role;sensor;side effect;Signal Pathway;Signal Transduction;Signaling Protein;Skeletal Muscle;skills;Source;stressor;Testing;Therapeutic;Therapeutic Agents;Therapeutic Intervention;therapeutic target;Training;Universities;Western Blotting;Wild Type Mouse;Work

PROJECT_TITLE: Investigating Isthmin as an adipose-to-muscle messenger that promotes muscle protein synthesis

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Heart Disease;Infectious Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PHR: NARRATIVE Cardiovascular disease continues to take more human lives than all cancer combined, prompting the need for improved research models and treatment options. We propose to study the patient- specific vascularized model of adult human myocardium, in the context of ischemic injury and acute viral myocarditis. This work is designed to advance our understanding and treatment of two forms of heart disease, which differentially affect males and females.

PI_NAMEs: VUNJAK-NOVAKOVIC, GORDANA  (contact)

PROGRAM_OFFICER_NAME: LUNDBERG, MARTHA

PROJECT_TERMS: 2019-nCoV;Acute;Acute Myocarditis;Adult;Affect;Benchmarking;Biological;biological research;Biomedical Engineering;Blood Vessels;Bone Marrow;Cardiac;Cardiac Myocytes;cardiac regeneration;cardiac tissue engineering;cardioprotection;Cardiovascular Diseases;cell type;Cells;Cellular Structures;Chronic;Clinical;conditioning;Data;Derivation procedure;design;Development;Disease;Endothelial Cells;Engineering;Environment;extracellular vesicles;Female;Fibroblasts;Genetic;Genetic Variation;Grant;Heart Diseases;Heart Injuries;high risk;Hormonal;Hormones;Human;human induced pluripotent stem cells;Immune;improved;Individual;Individual Differences;induced pluripotent stem cell;Injury;insight;Ischemia;ischemic injury;Link;Macrophage;Maintenance;male;Malignant Neoplasms;Measures;mesenchymal stromal cell;Metabolic;Methodology;MicroRNAs;Modeling;Molecular;monocyte;Muscle Cells;muscle engineering;Myocarditis;Myocardium;Natural regeneration;Nature;Outcome;Paper;Patients;Perfusion;Phenotype;Population;predictive modeling;Predisposition;Progress Reports;Property;protective effect;Protocols documentation;Publications;Reperfusion Injury;Reporting;Research;Research Design;response;response to injury;sex;Sex Differences;Source;Specificity;stem cells;Testing;Therapeutic;Therapeutic Effect;therapy outcome;Tissue Model;Tissues;translational medicine;Translational Research;Vascularization;Vasculogenic;viral myocarditis;women versus men;Work

PROJECT_TITLE: Engineering Vascularized Cardiac Muscle

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences;Pediatric;Sleep Research;Substance Misuse;Underage Drinking

ORG_CITY: TAMPA

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF SOUTH FLORIDA

ORG_STATE: FL

PHR: Teenagers are universally short on sleep, and sleep loss contributes to a host of health issues, including alcohol use disorders. The impact of adolescent circadian disruption on sleep and stress, and resultant changes in alcohol seeking, will be examined in this proposal. Our goal is to determine whether circadian rhythm sleep disorders in adolescence drive immediate or later alcohol seeking by increasing sleep disruption and stress, and whether strategies should be targeted to improving rhythmicity or sleep itself to reduce alcohol use disorder in adolescence and beyond.

PI_NAMEs: GULICK, DANIELLE  (contact)

PROGRAM_OFFICER_NAME: KUMAR, SHAILESH

PROJECT_TERMS: 20 year old;Abstinence;Academy;addiction;Address;Adenosine;Adolescence;Adolescent;adolescent alcohol abuse;adolescent alcohol effect;adolescent alcohol exposure;Adrenal Glands;Adult;Age;age group;Alcohol abuse;alcohol availability;Alcohol consumption;Alcohol dependence;alcohol effect;alcohol reward;alcohol risk;alcohol seeking behavior;alcohol use disorder;alcohol use initiation;Alcohols;American;Anxiety;Attenuated;automobile accident;Back;Beds;Behavior;behavior measurement;Behavioral;binge drinking;Biological;biological adaptation to stress;Biological Clocks;C57BL/6 Mouse;Cellular Phone;circadian;Circadian desynchrony;Circadian Dysregulation;Circadian gene expression;Circadian Rhythm Sleep Disorders;Circadian Rhythms;cognitive function;Corticosterone;Corticotropin-Releasing Hormone Receptors;cost;Cues;Delayed Sleep Phase Syndrome;drinking;Drowsiness;druggable target;Electronics;Endorphins;falls;Feeds;Female;Foundations;Goals;Habits;Health;healthcare community;high school;Homeostasis;Hour;Hypothalamic structure;improved;improved outcome;improvement on sleep;Intervention;Knowledge;Lead;Life;Light;Long-Term Effects;Male Adolescents;Measures;Melatonin;Modeling;Molecular;Mood Disorders;Motivation;Mus;Neurobiology;novel;Pathway interactions;Pattern;Pediatrics;Periodicity;Phenotype;Physiological;Pituitary Gland;Predisposition;Prevalence;Protocols documentation;Punishment;Recommendation;reduced alcohol use;Reporting;Research;Resistance;response;Rewards;Risk;Risk Reduction;Role;Schedule;Schools;sex as a biological variable;Signal Transduction;Sleep;Sleep Deprivation;Sleep Disorders;Sleep disturbances;sleep onset;sleep pattern;sleep quality;stem;Stress;stress reactivity;stressor;System;Teenagers;Testing;Time;time use;transition to adulthood;twelfth grade;underage drinking;United States;Violence;Work

PROJECT_TITLE: Effects of circadian desynchrony during adolescent alcohol exposure on immediate and long-term risk of alcohol addiction: role of sleep homeostasis and stress signaling

STUDY_SECTION: AA

STUDY_SECTION_NAME: Clinical, Treatment and Health Services Research Study Section[AA-3]


NIH_SPENDING_CATS: Biotechnology;Digestive Diseases;Infant Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: PROJECT NARRATIVE Necrotizing enterocolitis (NEC) is a devastating intestinal problem that often requires surgical resection of necrotic intestine. In this proposal, we utilize a novel hydrogen sulfide probe in conjunction with iPSC derived mesenchymal stem cells to study the hypothesis that hydrogen sulfide is a critical paracrine factor in stem cell mediated intestinal protection. A novel mouse with a mutation on endothelial nitric oxide synthase will also be used to study the ability of hydrogen sulfide to augment nitric oxide mediated mesenteric vasodilation.

PI_NAMEs: MARKEL, TROY A (contact)

PROGRAM_OFFICER_NAME: ANDERSEN, DANA K

PROJECT_TERMS: Abdomen;absorption;Angiogenesis Modulating Agents;Animals;Apoptosis;Award;Biological Assay;biological systems;Blood flow;career;Cell Culture System;cell motility;Cell Proliferation;Cell Therapy;Cells;Cessation of life;Childhood;Clinical;Clinical Trials;Collaborations;cost;critical limb Ischemia;Data;Death Rate;Degenerative polyarthritis;design;Detection;detection method;Development;Diabetic Foot Ulcer;Emergency Situation;Endothelium;Enzyme Precursors;Enzymes;Equilibrium;Esters;Evaluation;Excision;Exhibits;experimental study;Funding;Gases;Generations;Genetic;Goals;graft vs host disease;Grant;gut microbiome;Gut Mucosa;Harvest;Human;Hydrogen Sulfide;Hypoxia;Immune;immunogenicity;improved;In Situ;In Vitro;in vivo;in vivo Model;induced pluripotent stem cell;Infant;Inflammatory Response;Infrastructure;Infusion procedures;innovation;Institution;International;intestinal injury;Intestines;Intra-abdominal;Ischemia;Laboratories;Length;Measures;Mediating;Mediator;Medical;Medical Care Costs;Mentors;Mesenchymal Stem Cells;Mesentery;Methods;minimally invasive;Modality;Modeling;Mus;Mutation;Myography;nanomolar;National Institute of Diabetes and Digestive and Kidney Diseases;Necrosis;Necrotizing Enterocolitis;Neonatal;Nitric Oxide;NOS3 gene;novel;nutrition;Operative Surgical Procedures;Outcome;overexpression;paracrine;Patients;Phase;polysulfide;Population;porcine model;pre-clinical;premature;Premature Infant;pressure;Production;Property;Quality Control;Recovery;Research;Research Personnel;Role;Safety;Scientist;Sepsis;Signal Transduction;Signaling Molecule;Source;stem cell therapy;stem cells;Stress;Sulfur;Surgeon;System;systemic inflammatory response;Testing;Therapeutic Effect;therapeutically effective;Tissues;Transgenic Mice;Transplantation;Tyrosine;Universities;Vasodilation;Veterinarians;Volatilization

PROJECT_TITLE: Sulfur Based Stem Cell Therapeutics in Necrotizing Enterocolitis

STUDY_SECTION: DHMI

STUDY_SECTION_NAME: Digestive System Host Defense, Microbial Interactions and Immune and Inflammatory Disease Study Section[DHMI]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Infectious Diseases;Microbiome

ORG_CITY: RALEIGH

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: NORTH CAROLINA STATE UNIVERSITY RALEIGH

PHR: Project Narrative The work proposed here seeks to elucidate how opportunistic bacteria evolve and adapt to multiple environments, what traits are important for different environments, and how often traits are exapted. Results will have important health implications as they will reveal traits important for host colonization and virulence, which can be used for the development of new treatment strategies for combating multidrug resistant opportunistic bacterial infections.

PI_NAMEs: RAYMANN, KASIE TYLER (contact)

PROGRAM_OFFICER_NAME: KEANE-MYERS, ANDREA

PROJECT_TERMS: Address;Animals;Apis;Attenuated;Automobile Driving;Bacteria;Bacterial Genome;Bacterial Infections;Bacterial Model;Biological Assay;Biological Models;Communities;Comparative Genomic Analysis;comparative genomics;Complex;cost effective;Dangerousness;Development;driving force;Environment;Evolution;Exhibits;Exposure to;fitness;fitness test;General Practitioners;Generations;Genes;Genome;Genomic approach;Gnotobiotic;Health;host colonization;host microbiome;host microbiota;host-microbe interactions;human pathogen;in silico;In Vitro;in vivo;in vivo evaluation;insight;Libraries;Life Style;microbiota;Multi-Drug Resistance;mutant;Mutation;mutualism;Nosocomial Infections;novel strategies;novel therapeutic intervention;opportunistic pathogen;Organism;pathogen;Pathogenicity;Phenotype;Predatory Behavior;pressure;Process;programs;Pseudomonas aeruginosa;Research;Resistance;Role;Serratia marcescens;Sterility;Superbug;Symbiosis;System;Technology;Testing;trait;Virulence;Work

PROJECT_TITLE: Deciphering the processes of adaptation and exaptation driving the evolution of opportunism in bacteria

STUDY_SECTION: GVE

STUDY_SECTION_NAME: Genetic Variation and Evolution Study Section[GVE]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Aging

ORG_CITY: WORCESTER

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

ORG_STATE: MA

PHR: Project Narrative A decline in mitochondrial function occurs during aging, which is accelerated in age-associated diseases such as Alzheimer’s Disease and Parkinson’s Disease. Thus, understanding how cells establish a mitochondrial network during development and adjust that network throughout a cell’s lifetime to meet physiological needs is a necessary step to develop therapies that treat mitochondrial dysfunction and associated diseases. Here, we aim to understand the mechanisms by which the Integrated Stress Response regulates mitochondrial expansion and stress signaling to promote healthy aging.

PI_NAMEs: KIM, SOOKYUNG  (contact)

PROGRAM_OFFICER_NAME: FU, YI-PING

PROJECT_TERMS: Acceleration;activating transcription factor 1;activating transcription factor 4;age-related disease;Aging;Alzheimer's Disease;Amino Acids;animal old age;Animals;attenuation;Biogenesis;biological adaptation to stress;Biology;Caenorhabditis elegans;cell growth;Cell Nucleus;Cell Physiology;cell type;Cells;common cellular transcription factor ATF;deprivation;Development;Disease;Disease Progression;EIF-2alpha;endoplasmic reticulum stress;Ensure;Equipment;Exhibits;extend lifespan;Functional disorder;Genetic;Genetic Transcription;Growth Factor;Health;healthspan;healthy aging;human old age (65+);Impairment;improved;Individual;life span;Link;Longevity;Mediating;Metabolic;Mitochondria;mitochondrial dysfunction;mitochondrial genome;Mitochondrial Proteins;Muscle;Muscle function;mutant;Mutation;Neurodegenerative Disorders;Neurons;novel;Output;overexpression;Parkinson Disease;Pathway interactions;Peptide Initiation Factors;PERK kinase;Phosphorylation;Phosphorylation Site;Phosphotransferases;Physiological;Play;prevent;programs;Property;Protein Biosynthesis;Protein Import;Proteins;Reagent;Recovery;response;Role;Signal Pathway;Signal Transduction;Signal Transduction Pathway;Stress;stressor;Testing;Therapeutic;therapy development;transcription factor;Translations;Work

PROJECT_TITLE: Modulation of mitochondrial biogenesis by the Integrated Stress Response (ISR)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-D(21)L]