NIH_SPENDING_CATS: Prevention

PHR: Project Narrative: Project 4 Project 4 is researching the formation of the pollutants called EPFRs, which are associated with the emission of PM from TT of Superfund site materials. We are focused on revealing the mechanism of EPFR activation in biological media and the generation of hydroxyl radicals, which are responsible for health effects associated with PM exposure. We are also developing methods for EPFR emission control during TT of Superfund site wastes, as well as methods for detection of EPFRs in communities residing near TT sites.

PI_NAMEs: LOMNICKI, SLAWO M (contact)

PROJECT_TERMS: absorption;Acceleration;Address;Affect;Air;airway surface liquid;Alveolar;Anions;aqueous;Biological;Biological Models;biological systems;Blood;Cardiac health;Cardiopulmonary;Chemicals;Collaborations;Color;Communities;Complex;Computing Methodologies;Copper;Detection;detection method;Development;Devices;dibenzo(1,4)dioxin;diphenyl;electron density;Electronics;Ensure;Environment;experimental study;Foundations;Free Radical Formation;Free Radicals;Furans;Gases;Generations;Goals;Hazardous Waste;Health;Hydrolysis;Hydroxyl Radical;In Situ;Ionic Strengths;Iron;Laboratories;Liquid substance;Measurement;Medial;Metals;Methods;Methylene blue;Modeling;Nickel;Oxidation-Reduction;particle;Particulate Matter;pollutant;Population;portability;prevent;Prevention;Preventive;Process;Property;Protons;Pump;rapid detection;Reaction;remediation;Research;respiratory health;Sampling;sensor;Sensory;Serum;Signal Recognition Particle;Soil;Spectrometry;Study models;Sulfides;Sulfur Compounds;Superfund;superfund site;System;Technology;technology development;Testing;Time;timeline;tool;Toxicity Tests;treatment site;Visible Radiation;wasting;Work;Zinc

PROJECT_TITLE: Activation, Sensing, and Prevention of Formation of EPFRs in Thermal Treatment of Superfund Wastes


ADMINISTERING_IC: ES

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

ORG_CITY: BATON ROUGE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PHYSICS

ORG_FIPS: US

ORG_NAME: LOUISIANA STATE UNIV A&M COL BATON ROUGE

ORG_STATE: LA

PHR: Project Narrative: Project 5 The researchers in Project 5 are determining the microscopic identity of a new chemical species, an interfacial pollutant called an EPFR. As well as understanding the microscopic structure of these new chemical species, we are studying the elementary processes that are responsible for their formation (e.g., charge and spin transfer) as well as their decay. In so doing, we will be able to design rational and effective approaches for limiting the production of EPFRs and also for neutralizing them once formed, thereby ameliorating their dangerous health effects.

PI_NAMEs: SPRUNGER, PHILLIP  (contact)

PROJECT_TERMS: Address;Adsorption;Affect;Air;base;Binding;Biochemical;Charge;Chemicals;Chemistry;clay;Complex;computer studies;Computing Methodologies;Dangerousness;Degradation Pathway;Dependence;Development;Dust;Electron Transport;electronic structure;Electronics;Electrons;Environment;Environmental Risk Factor;Environmental Science;experimental study;Exposure to;fly ash;Free Radical Formation;Free Radicals;Generations;Goals;Hazardous Substances;Hazardous Waste;Hazardous Waste Sites;Health;Humidity;Individual;insight;interfacial;Joints;Knowledge;Laboratories;Longevity;Magnetic Resonance;metal oxide;Metals;Methods;Microscopic;Minerals;Modeling;Molecular;nanocluster;nanoparticle;Neutrons;oxidation;Oxidation-Reduction;Oxides;particle;Particulate Matter;Pathway interactions;Photochemistry;Photons;pollutant;Powder dose form;Prevention;Prevention strategy;Process;Production;programs;Property;Radiation;rational design;Reactive Oxygen Species;remediation;Research;Research Personnel;Risk Assessment;Roentgen Rays;Route;Sampling;Signal Recognition Particle;Soil;Soot;Spectrum Analysis;Structure;Superfund;superfund site;Surface;System;Techniques;Temperature;Toxic effect;Translating;trend;ultrafine particle;Variant;Work

PROJECT_TITLE: Microstructural Pathway of EPFR Formation and their Decay Mechanisms


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Digestive Diseases;Liver Disease

ORG_CITY: CHARLESTON

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: Project Narrative - MUSC Gastroenterology (GI) and Hepatology Medical Student (MUSC-GIHMS) Training Program The pool of physicians engaged in research is shrinking, and there is a need for physician researchers. The goal of the MUSC Gastroenterology (GI) and Hepatology Medical Student (MUSC-GIHMS) Training Program is to engage, inspire, and excite talented medical students in the area of biomedical research on digestive, pancreatic, and liver disease through a focused program specifically designed to facilitate and enhance a research experience for them. We anticipate that students who are exposed to GI research through this program will be motivated to pursue a career in GI and liver disease oriented research.

PI_NAMEs: ROCKEY, DON C. (contact)

PROGRAM_OFFICER_NAME: SASLOWSKY, DAVID E

PROJECT_TERMS: Academic Medical Centers;Address;Area;Biomedical Research;career;Clinical Investigator;Credentialing;Dedications;design;Development;didactic education;Digestive System Disorders;Disease;Education;Educational Curriculum;Educational workshop;Ensure;Evaluation;experience;Exposure to;Fostering;Funding Opportunities;Future;Gastroenterology;gastrointestinal;Gastrointestinal Diseases;Goals;Hepatology;improved;Infrastructure;innovation;Institution;interest;Knowledge;Lead;Liver;Liver diseases;Medical;medical schools;Medical Students;Medicine;Mentors;Mentorship;Mission;Motivation;National Institute of Diabetes and Digestive and Kidney Diseases;Needs Assessment;novel;Pancreatic Diseases;Patient Care;Physicians;Positioning Attribute;programs;Publications;Recommendation;recruit;Reporting;Research;Research Personnel;Research Project Grants;Research Training;research vision;Residencies;Resources;Scholarship;scientific organization;Scientist;skills;South Carolina;Strategic Planning;Structure;Students;success;Talents;Testing;Time;Training;Training Programs;United States National Institutes of Health;Universities;Vision;Work;Workforce Development

PROJECT_TITLE: MUSC GI and Hepatology Medical Student Training Program

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-7 (O1)]


ADMINISTERING_IC: GM

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: DURHAM

ORG_DEPT: PHARMACOLOGY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE Retrotransposons are the most abundant elements in animal genome and their activation has fundamental impact on host biology. Our proposed study aims to understand how retrotransposons achieve their DNA replication to shape host biology via a process of circular DNA production. This research will have the potential to provide new insights on controlling retrotransposons and on harnessing them to improve human health.

PI_NAMEs: ZHANG, ZHAO  (contact)

PROGRAM_OFFICER_NAME: MACARTHUR, LINDA

PROJECT_TERMS: Aging;Animals;Area;Automobile Driving;Biogenesis;Biological Process;biological systems;Biology;Biomedical Research;Circular DNA;computational pipelines;Conflict (Psychology);Data;Development;Disease;DNA;DNA biosynthesis;DNA Integration;DNA Repair;DNA Repair Pathway;DNA Sequence;Docking;Drosophila genus;ds-DNA;Elements;Embryonic Development;Event;Gametogenesis;Genetic;genetic information;Genetic Screening;Genome;Genomic Instability;genomic RNA;genomic variation;Genomics;Goals;Health;Human;human embryonic development;Human Genome;improved;insight;Knowledge;Life Cycle Stages;Malignant Neoplasms;manufacture;Measures;Mediating;Messenger RNA;Molecular;Monitor;mouse genome;Mus;Names;nanopore;Neurodegenerative Disorders;novel strategies;Oocytes;Oogenesis;Paste substance;Pathologic;Pathology;Pathway interactions;Physiological;Physiology;Play;prevent;Process;Production;Replication-Associated Process;Research;Retrotransposon;RNA;RNA-Directed DNA Polymerase;Shapes;Source;Sterility;System;Testing;tool;tumorigenesis;Virus Diseases;Work;Writing

PROJECT_TITLE: Biogenesis and function of retrotransposon-derived circular DNA

STUDY_SECTION: GVE

STUDY_SECTION_NAME: Genetic Variation and Evolution Study Section[GVE]


ORG_CITY: CHAPEL HILL

ORG_DEPT: GENETICS

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: NARRATIVE While U.S. demographics are becoming increasingly diverse, individuals from historically underrepresented groups are lacking in the biomedical workforce. As studies indicate that diverse teams outperform homogeneous teams, this underrepresentation compromises the capacity to build high-performing scientific research teams. Thus, the goal of UNC PREP in the Biomedical Sciences is to address this need by equipping, encouraging, and empowering talented undergraduates from groups that have been historically underrepresented in the biomedical workforce to pursue and succeed in top biomedical graduate programs and careers through immersive, mentored research experiences, comprehensive relevant professional development, and a continued support network upon program completion.

PI_NAMEs: ROBINSON, DONITA L (contact);RODRIGUEZ-ROMAGUERA, JOSE

PROGRAM_OFFICER_NAME: AKACEM, LAMEESE DANA

PROJECT_TERMS: Academia;Address;Area;Biological;Biomedical Research;career;Career Choice;Career Exploration;Communities;demographics;design;Development;Development Plans;Doctor of Philosophy;Educational Curriculum;Educational process of instructing;Elements;empowerment;Equity;Evolution;expectation;experience;Faculty;Foundations;Funding;Future;Goals;Government;graduate school;graduate student;Health;improved;Individual;Industry;Institution;Laboratories;Laboratory Research;Lead;Leadership;Literature;matriculation;Measures;member;Mentors;Mentorship;Mind;Outcome;Outcome Assessment;Population;Positioning Attribute;Postbaccalaureate;Postdoctoral Fellow;Productivity;programs;Publications;Research;Research Personnel;Research Project Grants;Research Training;Resources;Science;Scientist;Self Efficacy;skills;social engagement;stem;STEM career;Students;success;support network;Talents;Time;Training;undergraduate student;Underrepresented Populations

PROJECT_TITLE: UNC PREP in the Biomedical Sciences

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - D[TWD-D]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: BOSTON

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

ORG_STATE: MA

PHR: Project Narrative We have discovered highly active, orthogonal sortase mutants that recognize unique peptide sorting motifs, enabling repeated covalent assembly and disassembly of surface bound biomolecular constituents, thereby providing a means to regenerate anti-thrombotic constituents on blood contacting films after device implantation. We have also developed new chemoenzymatic schemes leading to the discovery of a synthetic heparin that is resistant to heparanase mediated biodegradation, forming the basis of a novel family of highly durable and rechargeable heparin thin films. We believe that breakthroughs by the investigative team in protein engineering, carbohydrate synthesis, heparin structural biology, and materials science offer an opportunity to extend the lifetime of anti-thrombotic blood contacting films with a commensurate improvement in the clinical performance of a variety of implanted cardiovascular devices.

PI_NAMEs: CHAIKOF, ELLIOT  (contact)

PROGRAM_OFFICER_NAME: WARREN, RONALD Q

PROJECT_TERMS: analog;Anticoagulants;Automobile Driving;Binding;Biodegradation;Blood;Carbohydrates;Cardiopulmonary Bypass;Cardiovascular system;Charge;Clinical;computer studies;computerized tools;de-immunization;design;Development;Devices;Diameter;Directed Molecular Evolution;Drug Kinetics;Enzymes;experimental study;fabrication;Family;Film;Generations;heparanase;Heparin;Heparin Binding;Human;immunogenic;immunogenicity;Implant;implant coating;implantation;improved;In Situ;In Vitro;in vivo;innovation;Investigation;lead candidate;Legal patent;Ligation;Maintenance;Maps;materials science;Mediating;Molecular Target;mutant;Natural regeneration;New Zealand;novel;Oryctolagus cuniculus;Outcome;Pathway interactions;Peptides;Performance;Peripheral Blood Mononuclear Cell;Phase;Process;Property;Protein Engineering;Proteins;Recombinants;Reporting;Research Personnel;Resistance;respiratory assist;response;Risk;Scheme;Self-Help Devices;sortase;Sorting;Stents;structural biology;Surface;surface coating;T-Lymphocyte Epitopes;Therapeutic Uses;Thinness;Thrombin;thrombogenesis;Thrombomodulin;thrombotic;Thrombus;tool;Transgenic Mice;transpeptidation;Variant;Vascular Graft;Venous;Ventricular

PROJECT_TITLE: Rechargeable Anti-thrombogenic Films for Blood Contacting Applications

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


NIH_SPENDING_CATS: Aging;Cardiovascular;Estrogen;Heart Disease;Menopause;Women's Health Research

ORG_CITY: TUCSON

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: The proposed work aims to investigate the sex-specific myofilament-based alterations that underlie diastolic dysfunction in HFpEF and the role of female androgens in postmenopausal HFpEF. Understanding sex-based differences in HFpEF is essential for achieving personalized therapeutic approaches. Understanding HFpEF from a myofilament standpoint will provide potential insight into targeting myofilaments to alleviate diastolic dysfunction and limit disease progression.

PI_NAMEs: METHAWASIN, MEI  (contact)

PROGRAM_OFFICER_NAME: TJURMINA, OLGA A

PROJECT_TERMS: 4-vinylcyclohexene diepoxide;Androgen Antagonists;androgen excess;Androgens;Animal Model;Biological Assay;Cardiac;Cardiac Myocytes;cardiovascular risk factor;Cardiovascular system;Cell Membrane Permeability;Cells;Chemicals;Clinical Research;connectin;Cyclic GMP;Data;Development;Diastole;Disease Progression;Disparate;EFRAC;Estrogen deficiency;Estrogen Replacement Therapy;Estrogens;Excision;Exhibits;experience;Extracellular Matrix;Female;Functional disorder;Goals;Heart Atrium;Heart failure;High Fat Diet;in vivo;Injections;insight;Kinetics;Knowledge;Lead;Left ventricular structure;male;Measures;Mechanics;Mediating;men;Menopause;Metabolic stress;Microfilaments;Microtubules;Modeling;mouse model;Mus;Myocardial;Myocardium;Myosin ATPase;Natriuretic Peptides;novel;Organ;Ovarian;Ovariectomy;Ovary;Oxidoreductase;Pathogenesis;Pathologic;Patients;Pattern;personalized therapeutic;Phenotype;Phosphorylation;Post-Translational Protein Processing;Postmenopause;preclinical study;Premenopause;preservation;Prevalence;Production;Prognosis;Property;Proteins;Proteomics;Publishing;Regimen;Relaxation;Reporting;Research;Residual state;Resistance;reuptake;RNA;Role;Sarcomeres;sex;Sex Differences;sexual dimorphism;sexual disparity;Signal Pathway;Signal Transduction;Therapeutic Intervention;therapeutic target;transcriptomics;translational progress;treatment response;Woman;Women's Role;Women's study;Work

PROJECT_TITLE: Sex-specific myofilament dysfunction in postmenopausal HFpEF

STUDY_SECTION: MPPA

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology A Study Section [MPPA]


NIH_SPENDING_CATS: Genetics

ORG_CITY: CHAMPAIGN

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

ORG_STATE: IL

PHR: This work will uncover cues that integrate DNA replication with cell cycle progression and genome stability and will entail comprehensive analyses on the role of pre-replicative proteins in interconnecting these events. The proposed research is relevant to public health because the accomplishment of the proposal will provide fundamental mechanistic insights into the mechanism of genome inheritance. Thus, the project is relevant to NIH’s mission of studying the molecular basis of the proper functioning of a cell, and this would have direct implications for biomedical research.

PI_NAMEs: PRASANTH, SUPRIYA G (contact)

PROGRAM_OFFICER_NAME: REDDY, MICHAEL K

PROJECT_TERMS: ATP phosphohydrolase;Binding;Biochemical;Biological;Biomedical Research;biophysical techniques;Cell Cycle;Cell Cycle Progression;cell growth;Cells;Chromatin;combat;Cues;Cytokinesis;Data;DNA biosynthesis;DNA Damage;DNA Integration;Event;experience;experimental study;Genome;Genome Stability;Genotoxic Stress;Goals;Heterochromatin;Histones;Human;Individual;innovation;innovative technologies;insight;Laboratories;Lasers;Licensing;Maintenance;Malignant Neoplasms;Mismatch Repair;Mission;Mitosis;Molecular;novel;ORC1L gene;origin recognition complex;Pathway interactions;Play;Positioning Attribute;Pre-Replication Complex;prevent;Process;programs;Proliferating;Proteins;Public Health;Replication Initiation;Replication Licensing;Research;response;Role;S phase;single molecule;Site;superresolution imaging;Techniques;therapeutic target;therapeutically effective;tool;tumorigenesis;United States National Institutes of Health;unpublished works;Work

PROJECT_TITLE: Mechanisms of Genome Stability

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MRAF-C (01)]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Infectious Diseases;Prevention

ORG_CITY: STANFORD

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: PROJECT NARRATIVE Many enteric pathogens that cause high levels of morbidity and mortality are spread via the fecal oral route. Thus, an increased understanding of the molecular mechanisms that influence pathogen persistence within granulomas and their impact on host-to-host transmission will have a large impact on human health.

PI_NAMEs: MONACK, DENISE M (contact)

PROGRAM_OFFICER_NAME: ALEXANDER, WILLIAM A

PROJECT_TERMS: Anti-Inflammatory Agents;Bacteria;Bacterial Infections;Biochemical;Carrier State;Cells;Chronic;chronic infection;Clinical;Critical Pathways;Data;Disease Progression;Disease Reservoirs;disease transmission;enteric pathogen;Gene Expression Profiling;Genetic;Goals;Granuloma;Health;Human;Immune;Immune response;Immunity;Immunologics;immunopathology;Infection;Inflammatory;Inflammatory Response;innovation;insight;Knowledge;Macrophage;man;MAPK8 gene;Mediating;Metabolic;microbial;Molecular;Monitor;Morbidity - disease rate;Morphology;mortality;Mus;Nature;NF-kappa B;novel marker;Oral;pathogen;Pathogenesis;Pathway interactions;persistent bacterial infection;pharmacologic;Phenotype;Preventive;preventive intervention;Publishing;Regulation;Research;Risk;Role;Route;Salmonella;Salmonella enterica;Salmonella infections;Salmonella typhimurium;Signal Pathway;Signal Transduction;Sorting;STAT3 gene;System;Systemic infection;Testing;Therapeutic;Therapeutic Intervention;Time;Tissues;TLR4 gene;TNF gene;transcription factor;transcriptomics;transmission process;Type III Secretion System Pathway;Virulence Factors;Visualization

PROJECT_TITLE: Mechanisms of persistent Salmonella infection

STUDY_SECTION: HIBP

STUDY_SECTION_NAME: Host Interactions with Bacterial Pathogens Study Section[HIBP]


NIH_SPENDING_CATS: Antimicrobial Resistance;Infectious Diseases;Machine Learning and Artificial Intelligence

ORG_CITY: Nashville

ORG_DEPT: PHYSIOLOGY

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: Steady emergence of microbes displaying acquired drug resistance phenotypes has prompted health organizations to declare multidrug resistance a global public health concern. In addition, multidrug resistance compromises the efficacy of cancer treatment. The proposed studies will yield a structural dynamic blueprint for transporters underlying basic multidrug resistance phenomena in bacteria and humans, knowledge which can be exploited to develop strategies to inhibit these transporters.

PI_NAMEs: MCHAOURAB, HASSANE S (contact)

PROGRAM_OFFICER_NAME: TAYLOR, VERONICA

PROJECT_TERMS: acquired drug resistance;Address;ATP Hydrolysis;Bacteria;Bacterial Infections;Binding;Binding Sites;cancer therapy;Cell membrane;Cells;Clinical;Coupled;Coupling;Cryoelectron Microscopy;cytotoxic;Drug resistance;efflux pump;Electrons;Elements;Environment;Family;Free Energy;Goals;health organization;Human;innovation;Investigation;Ions;Isomerism;Knowledge;Lipid Bilayers;Lipids;Machine Learning;Mediating;Membrane;Microbe;Molecular Conformation;Multi-Drug Resistance;Mycoses;neoplasm chemotherapy;overexpression;Pharmaceutical Preparations;Phenotype;Productivity;programs;protein structure prediction;Public Health;Research;Resolution;Shapes;solute;spectral energy;Spectrum Analysis;Structure;Tertiary Protein Structure;tool;Toxin

PROJECT_TITLE: Structural Dynamics of Active Transporters

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MBBC-R (55)]


NIH_SPENDING_CATS: Biomedical Imaging;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Genetics;Human Genome;Liver Disease;Pediatric;Prevention

PHR: PROJECT NARRATIVE The association between early life exposures and development of non-alcoholic fatty liver disease (NAFLD) in children and young adults may be mediated by epigenetic mechanisms; however, the specific epigenetic modifications implicated in NAFLD risk remain largely unknown. We recently identified 1,488 novel putative human imprinted gene control regions throughout the genome and our goal is to identify aberrant methylation in those imprint control regions that is associated with the development of NAFLD. We propose one of the most rigorous investigations of this association, leveraging a large, multi-ethnic birth cohort with longitudinal data and specimens from birth to young adulthood, state of the art imaging of liver fat content and fibrosis, and a novel array able to systematically measure methylation at all imprint control regions – mechanistically linking early life to NAFLD and laying the foundation for improved early detection.

PI_NAMEs: HOYO, CATHRINE ;MOYLAN, CYNTHIA A (contact)

PROGRAM_OFFICER_NAME: PAWLIKOWSKA, LUDMILA SYLWIA

PROJECT_TERMS: Adolescence;Adolescent;Adult;Affect;aged;American;Birth;Blood specimen;Blood Tests;Cell division;Characteristics;Child;Childhood;chronic liver disease;Circulation;Cirrhosis;Clinical;Clinical Research;cohort;combat;CpG dinucleotide;Data;Development;Diagnosis;Disease;Disease Marker;disease natural history;disorder risk;DNA Methylation;early detection biomarkers;Early Diagnosis;early life exposure;elastography;end stage liver disease;Enrollment;Environmental Exposure;Enzymes;Epidemic;Epigenetic Process;Ethnic Origin;Etiology;Exhibits;Fatty acid glycerol esters;Fibrosis;follow-up;Foundations;Gametogenesis;Gene Dosage;Gene Expression;gene function;gene network;Genes;Genome;Genomic Imprinting;Germ Cells;Goals;Growth;Growth and Development function;Health;Heritability;Human;Image;imprint;improved;Inflammation;inter-individual variation;Investigation;Knowledge;Leukocytes;Life;Life Cycle Stages;Link;Lipids;Liver;Liver Dysfunction;Liver Fibrosis;liver imaging;Longitudinal cohort;Magnetic Resonance Imaging;Maps;Measurement;Measures;Mediating;Metabolic;Metabolic Diseases;Metabolic dysfunction;Metabolism;Methylation;Mitotic;Modification;Morbidity - disease rate;mortality;multi-ethnic;Newborn Infant;non-alcoholic fatty liver disease;Non-Insulin-Dependent Diabetes Mellitus;nonalcoholic steatohepatitis;novel;Nucleic Acid Regulatory Sequences;Obesity;Outcome;pediatric non-alcoholic fatty liver disease;peripheral blood;Play;Positioning Attribute;Pregnant Women;Promoter Regions;Public Health;Publishing;Questionnaires;recruit;Regulation;Regulator Genes;Resources;response;Risk;Role;sex;Somatic Cell;Specimen;Technology;Testing;Therapeutic;Time;Tissues;tool;transmission process;Triglycerides;ultrasound;Umbilical Cord Blood;waist circumference;Work;young adult

PROJECT_TITLE: Genomic Imprinting in the Development of NAFLD

STUDY_SECTION: KEDD

STUDY_SECTION_NAME: Kidney Endocrine and Digestive Disorders Study Section[KEDD]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Genetics;Women's Health Research

ORG_CITY: ANN ARBOR

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative We plan to develop potent and selective small molecule inhibitors of NSD3 histone methyltransferase activity as novel chemical probes to evaluate oncogenic activity of NSD3 in breast cancer models with 8p11-12 amplifications.

PI_NAMEs: CIERPICKI, TOMASZ  (contact)

PROGRAM_OFFICER_NAME: AGYIN, JOSEPH KOFI

PROJECT_TERMS: 8p11;Affect;Allosteric Site;Animal Model;Binding;Biology;Breast Cancer Cell;Breast Cancer Model;Breast Cancer Patient;breast cancer progression;breast cancer survival;Breast Carcinoma;Cancer Biology;cancer cell;Cells;Chemicals;Chromatin;Complex;Cysteine;design;Development;Disease;Distant;Drug Kinetics;efficacy testing;Epigenetic Process;Family;Gene Expression;Genes;Genetic Transcription;genomic locus;Goals;Growth;Head and neck structure;Histone H3;histone methyltransferase;Histones;Human;Impairment;improved;in vivo;Induction of Apoptosis;inhibitor;knock-down;Length;Literature;Lung;Lysine;Malignant Breast Neoplasm;Malignant neoplasm of pancreas;Malignant Neoplasms;member;Mus;novel;novel therapeutics;Nuclear Family;Nuclear Receptors;Oncogenic;Outcome;overexpression;Pathologist;patient derived xenograft model;Patient-derived xenograft models of breast cancer;Patients;Pharmaceutical Chemistry;Pharmacology;Play;preclinical study;Prognosis;Proliferating;Property;Protein Family;Protein Isoforms;Proteins;receptor binding;Recurrence;Reporting;Resolution;Role;screening;SET Domain;small molecule;small molecule inhibitor;Solubility;structural biology;Structure;Tertiary Protein Structure;Toxic effect;tumor;tumorigenesis;Xenograft Model

PROJECT_TITLE: Development of chemical probe targeting NSD3 SET domain in breast cancer

STUDY_SECTION: CBP

STUDY_SECTION_NAME: Chemical Biology and Probes Study Section[CBP]


NIH_SPENDING_CATS: Clinical Research;Emerging Infectious Diseases;Hematology;Infectious Diseases;Pediatric;Prevention;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: PROJECT NARRATIVE Small vessel injury leads to multi-organ impairment and death in children undergoing bone marrow transplant through the development of thrombotic microangiopathy or TMA. The proposed research project will test the hypothesis that TMA is triggered by dysregulation of components of the immune system, namely complement and interferon. Examining longitudinal blood samples from children with and without TMA will identify key initiators of TMA, allowing for the future study of targeted treatments to prevent organ damage and death.

PI_NAMEs: BLACKARD, JASON T;JODELE, SONATA  (contact);LASKIN, BENJAMIN LEWIS

PROGRAM_OFFICER_NAME: NEIDERT, LESLIE EAVES

PROJECT_TERMS: 1-Phosphatidylinositol 4-Kinase;Acute Graft Versus Host Disease;Adopted;Allogenic;Award;BK Virus;Blood;Blood specimen;Blood Vessels;Bone Marrow Transplantation;Calcineurin inhibitor;Cell Therapy;Cessation of life;chemotherapy;Child;Clinical;clinical care;Clinical Trials;cohort;Collaborations;Complement;Complement Activation;Complement Inactivators;conditioning;Consensus;Cox Models;CXCL9 gene;Cystitis;Data;design;Detection;Development;Diagnosis;diagnostic criteria;differential expression;druggable target;Endothelium;Enrollment;evidence base;Freezing;Functional disorder;Funding;Future;gene complementation;gene panel;Genetic Complementation Test;genetic signature;Genomics;Genotype;Goals;Graft versus host disease prophylaxis/therapy;graft vs host disease;Hematopoietic Stem Cell Transplantation;Hemorrhage;high risk;high risk population;Immune system;Impairment;improved;improved outcome;Infection;Infusion procedures;inhibitor;Injury;Interferon Activation;Interferon Type II;Interferons;International;Intervention Studies;Intervention Trial;Investigation;Knowledge;Measures;Mediating;Mediation;Membrane;Modeling;Morbidity - disease rate;mortality;mortality risk;Natural History;novel;novel strategies;Organ;Pathway interactions;Patients;Pediatric Hospitals;Performance;Phenotype;Philadelphia;Polyomavirus Infections;Predisposition;prevent;Prevention;Prophylactic treatment;prospective;protein expression;Proteins;Proteomics;Publishing;Qualifying;Research;Research Project Grants;Resolution;response;Risk;Risk Factors;Role;Sampling;Severities;Signal Transduction;Signaling Protein;soluble complement C5b-9;Standardization;System;T-Lymphocyte;Testing;Therapeutic;thrombotic;Time;time use;Transplant Recipients;Transplantation;transplantation therapy;treatment strategy;Universities;Up-Regulation;Viral;Viremia;Virus;Virus Replication;young adult

PROJECT_TITLE: Initiators of thrombotic microangiopathy

STUDY_SECTION: CCHS

STUDY_SECTION_NAME: Clinical Integrative Cardiovascular and Hematological Sciences Study Section[CCHS]


NIH_SPENDING_CATS: Cancer;Clinical Research;Hematology;Infectious Diseases;Lymphatic Research;Lymphoma;Malaria;Pediatric;Pediatric Cancer;Rare Diseases;Vector-Borne Diseases

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Endemic Burkitt's lymphoma (BL), the most prevalent childhood cancer in Equatorial Africa, is a rapidly growing B-cell malignancy that is ultimately fatal if untreated. The knowledge gained by this study will improve the understanding of the etiology of endemic BL which will ultimately allow for the design of tools aimed at the prevention of BL.

PI_NAMEs: SAMAYOA REYES, GABRIELA M (contact)

PROGRAM_OFFICER_NAME: ALARCON, RODOLFO M

PROJECT_TERMS: activation-induced cytidine deaminase;Acute;Africa;Africa South of the Sahara;African Burkitt's lymphoma;B lymphoid malignancy;B-Cell Activation;B-Lymphocyte Subsets;B-Lymphocytes;BACH2 gene;Binding;Biology;Burkitt Lymphoma;C-Myc Translocation;cancer cell;Cell Line;Cell Nucleus;Cell Separation;Cells;Cellular biology;Characteristics;Child;Childhood;Circulation;Clinical;cofactor;Complex;cytokine;Cytolysis;Cytoplasm;Data;design;Disease;DNA;EBV reactivation from latency;Enzyme Activation;Epstein-Barr Virus latency;Epstein-Barr Virus-Related Malignant Neoplasm;Etiology;Event;Falciparum Malaria;Flow Cytometry;Frequencies;Genetic Transcription;Genome;Goals;Heme;hemozoin;high risk;Human Herpesvirus 4;IGH@ gene cluster;improved;Individual;infected B cell;Infection;Kenya;Knowledge;Life;Ligands;Link;Lymphocyte;Lytic;Lytic Virus;Malaria;malaria infection;Malignant Childhood Neoplasm;Malignant Neoplasms;Mediating;Memory B-Lymphocyte;Methylation;methylome;Modeling;Molecular;MYC gene;nanopore;pathogen;Peripheral Blood Mononuclear Cell;Phenotype;Plasma;plasma cell differentiation;Plasma Cells;Plasmodium falciparum;Population;Prevention;Research;Risk;RNA;Role;Sampling;Site;Structure of germinal center of lymph node;synergism;Testing;Time;Tonsil;tool;Transcript;transcription factor;tumorigenesis;Variant;Viral;Viral Load result;Viremia;Virus

PROJECT_TITLE: The synergistic contributions of EBV and malaria to the etiology of Burkitt lymphoma

STUDY_SECTION: VIRB

STUDY_SECTION_NAME: Virology - B Study Section[VIRB]


ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Public Health Relevance Blood pressure is higher in males than it is in females. We discovered that a receptor known as OLFR558 is responsible for this sex difference, but we don’t understand how OLFR558 is regulated. In this proposal, we will study activators (‘ligands’) for OLFR558 to reveal how it regulates blood pressure differently in males and females, and to determine if modulating OLFR558 is a potential therapy in hypertension.

PI_NAMEs: PLUZNICK, JENNIFER L (contact);SLEPAK, VLADLEN Z

PROGRAM_OFFICER_NAME: MARIC-BILKAN, CHRISTINE

PROJECT_TERMS: Affect;Age;Agonist;Agreement;Angiotensin II;antagonist;Antibiotics;Attenuated;Blood Pressure;blood pressure elevation;blood pressure reduction;blood pressure regulation;Blood Vessels;Cells;Communication;Data;Diastolic blood pressure;DOCA;Exhibits;Female;follow-up;G-Protein-Coupled Receptors;Gene Family;Genes;Genetic;Genome;Germ-Free;Gonadal Hormones;gut microbes;gut microbiota;high throughput screening;Human;Hypertension;hypertensive;improved;In Vitro;in vitro Assay;in vivo;Juxtaglomerular Apparatus;Juxtaglomerular Cell;Kidney;Knock-out;Knockout Mice;Ligands;male;Measures;Mediating;Mediator;microbial;microbiome;microbiota;Molecular Probes;Mus;normotensive;Nose;novel;olfactory receptor;Oral;Orthologous Gene;Pathway interactions;pharmacokinetics and pharmacodynamics;pharmacologic;Phenotype;Physiologic pulse;Physiological;Physiology;Plasma;Play;Premenopause;Property;public health relevance;rare variant;receptor;Regulation;Renin;Reporting;Research;resident commensals;response;Role;Sensory;sex;Sex Differences;Signal Transduction;Smooth Muscle Myocytes;Sodium Chloride;Specificity;success;Telemetry;Therapeutic;Time;Tissues;tool;Vascular Smooth Muscle;Volatile Fatty Acids;Wild Type Mouse;Woman;Work

PROJECT_TITLE: Olfactory Receptor 558 (OLFR558) Ligands and Blood Pressure Regulation

STUDY_SECTION: IVPP

STUDY_SECTION_NAME: Integrative Vascular Physiology and Pathology Study Section[IVPP]


NIH_SPENDING_CATS: Kidney Disease

ORG_CITY: TAMPA

ORG_NAME: UNIVERSITY OF SOUTH FLORIDA

ORG_STATE: FL

PHR: The nephrology workforce in the Unites States is declining, despite a significant prevalence of kidney diseases and hypertension. There is an unmet need to engage undergraduate medical students in nephrology early in their career decision-making process. The goal of this proposal is to engage rising second-year medical students at the University of South Florida and the University of Florida in a 10-week summer program that will stimulate interest in the field of nephrology by allowing participants to (i) gain depth and better understanding of renal physiology, (ii) engage in experimental methods to elucidate kidney function, and (iii) see first-hand how basic science and clinical research translates to the patient bedside.

PI_NAMEs: DOMINGUEZ RIEG, JESSICA A (contact);RIEG, TIMO

PROJECT_TERMS: Acids;Address;Adult;Applications Grants;Area;Award;base;Basic Science;Bioethics;career;Caring;Chronic Kidney Failure;Clinical;Clinical Research;Decision Making;Development;Drops;Economic Burden;Education;education research;effective therapy;Electrolytes;Enrollment;Expenditure;experience;Exposure to;Florida;Fostering;glomerular function;Goals;hands on research;Healthcare;Homeostasis;Hypertension;interest;Journals;Kidney;Kidney Diseases;Knowledge;learning community;Life;Medical Education;medical schools;medical specialties;Medical Students;Medicare;Mentors;Mentorship;Methods;Mission;Names;National Institute of Diabetes and Digestive and Kidney Diseases;Nephrology;novel;Outcome;Participant;patient population;Patient-Focused Outcomes;Patients;Physicians;Physiology;pre-clinical;Prevalence;Process;programs;Public Health;recruit;Renal function;Research;Research Methodology;Research Project Grants;role model;Scientist;Structure;Students;summer program;Surveys;symposium;Time;Training;Training Activity;Translating;Tubular formation;undergraduate student;United States;United States National Institutes of Health;Universities;university student

PROJECT_TITLE: Research and Education in Nephrology for Undergraduate Medical Students-Florida (RENUM-FL)

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


PHR: PROJECT NARRATIVE C1 inhibitor is a multifunctional serine protease inhibitor that serves as a major endogenous inhibitor of the contact pathway of coagulation. This proposal will evaluate how endogenous C1 inhibitor regulates coagulation and thrombosis. This proposal will also evaluate the therapeutic potential of exogenous C1 inhibitor as a novel hemostasis sparing anticoagulant.

PI_NAMEs: GROVER, STEVEN P. (contact)

PROGRAM_OFFICER_NAME: GOLDBERG, ILANA GRACE

PROJECT_TERMS: Anticoagulants;Blood Vessels;Bradykinin;Case/Control Studies;Clinical;Coagulation Process;Complement;Complement component C1r;complement system;Contact Inhibition;Data;Data Set;Deep Vein Thrombosis;Development;Disease;epidemiologic data;Event;factor V Leiden;Factor XI;Factor XII;Factor XIIa;FDA approved;Functional disorder;Hemostatic function;hereditary angioneurotic edema;Human;Inherited;inhibitor;insight;Intervention;Kininogenase;Life;Mediating;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;novel;Pathogenesis;Pathologic;Pathway interactions;Patients;Permeability;pharmacologic;Phenotype;Plasma;Play;Population;preclinical study;Preparation;prevent;Pulmonary Embolism;Rare Diseases;Regulation;Reporting;Risk;Role;Sampling;Serine Proteinase Inhibitors;Swelling;Testing;Therapeutic;Thrombin;Thrombophilia;Thrombosis;thrombotic;translational potential;United States;Variant;Venous;venous thromboembolism;Venous Thrombosis;Work

PROJECT_TITLE: Regulation of coagulation and thrombosis by C1 inhibitor

STUDY_SECTION: HTBT

STUDY_SECTION_NAME: Hemostasis, Thrombosis, Blood Cells and Transfusion Study Section[HTBT]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Contraception/Reproduction;Genetics;Infertility;Neurosciences;Urologic Diseases;Women's Health Research

PHR: This proposal will use fruit flies to investigate how the testis and reproductive neurons distinctively interpret the genetic code of life. Our approach takes a distinctive look at genetic code interpretation in the context of reproduction and fertility. Our preliminary findings in fruit flies closely parallel genetic code interpretation in humans, and so our studies are highly likely to impact human reproductive health.

PI_NAMEs: FOX, DONALD T. (contact)

PROGRAM_OFFICER_NAME: KENT, TRAVIS JOHN

PROJECT_TERMS: Amino Acids;Binding Proteins;Biochemistry;Bioinformatics;Biology;Brain;cell type;Cells;Code;Codon Nucleotides;Complex;Courtship;Data;Drosophila genus;Ensure;Female;Fertility;fly;Gametogenesis;Genes;Genetic;genetic approach;Genetic Code;Genetic Screening;Germ Cells;Human;Infertility;innovation;insight;Life;Link;male;male fertility;mating behavior;Messenger RNA;Modeling;Molecular;Molecular Biology;mRNA Decay;mRNA Stability;mRNA Transcript Degradation;mRNA Translation;nerve stem cell;Neurons;Oogenesis;Organism;Ovary;Partner in relationship;Process;progenitor;protein expression;Proteins;Proteome;Proteomics;Regulation;Reporter;Reproduction;reproductive;Reproductive Behavior;Reproductive Biology;Reproductive Health;Ribosomal Proteins;ribosome profiling;Ribosomes;RNA-Binding Proteins;Role;Spermatids;Spermatogenesis;Testis;Time;Tissues;Transcript;transcriptome sequencing;Transfer RNA;Translating;Translations;Work

PROJECT_TITLE: Regulation of fertility and reproduction by codon usage: a Drosophila model

STUDY_SECTION_NAME: Development - 2 Study Section[DEV2]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

ORG_CITY: ATHENS

ORG_NAME: UNIVERSITY OF GEORGIA

ORG_STATE: GA

PHR: Diversity in the biomedical research workforce elevates scientific innovation and impact to levels necessary to impact human health and well-being. Underrepresented minorities and persons with disabilities face systemic issues that impede their research training, which limits this diversity. This renewal of PREP@UGA builds on the program’s successes to date and continues to advance the diversity of the biomedical research workforce by recruiting recent post-baccalaureate underrepresented minority and disabled students and providing research-intensive training and professional development to facilitate their transition to and success in biomedical PhD programs.

PI_NAMEs: DOLAN, ERIN L;KLONOWSKI, KIMBERLY D. (contact)

PROGRAM_OFFICER_NAME: STEPANEK, LAURIE ELIZABETH

PROJECT_TERMS: Academia;Address;Awareness;Biological Sciences;Biomedical Research;career;Career Choice;career development;career networking;Characteristics;cohort;Communication;Communities;community building;Complement;Development;disability;Disabled Persons;disabled students;Discipline;diversity and inclusion;Doctor of Philosophy;Education;education research;ethnic diversity;Ethnic Origin;Evaluation;experience;Face;Faculty;faculty mentor;Feedback;Fellowship;Funding;Gender;gender diversity;Goals;Government;Graduate Education;graduate school preparation;Group Meetings;Health;Hispanic-serving Institution;Historically Black Colleges and Universities;Human;improved;Individual;Industry;innovation;Institution;Institutional Policy;Institutional Practice;Instruction;interest;International;Investments;journal article;Justice;Knowledge;Literature;matriculation;meetings;Mentors;Mentorship;Mission;National Institute of General Medical Sciences;Oral;Outcome;Paper;Personal Satisfaction;Positioning Attribute;Postbaccalaureate;Postdoctoral Fellow;programs;Publications;Publishing;Race;racial diversity;Reading;recruit;Reporting;Reproducibility;Research;Research Training;response;Science;Services;skills;social;Social Justice;social media;Social Sciences;Statistical Data Interpretation;Strategic Planning;Students;success;summer research;Surveys;symposium;synergism;Time;Training;Translations;Underrepresented Minority;underrepresented minority student;Underrepresented Populations;Underrepresented Students;United States National Institutes of Health;Universities;web site;Work;Writing

PROJECT_TITLE: PREP at University of Georgia


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Cancer;Climate-Related Exposures and Conditions;Clinical Research;Genetics;Health Effects of Indoor Air Pollution;Prevention

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

PHR: NARRATIVE There is limited information on health effects from wildland-urban interface (WUI) fires, which burn a mixture of vegetation, structures, and vehicles. The proposed research will work in partnership with firefighters to evaluate their exposures and toxic effects from WUI fires, and evaluate the effectiveness of exposure-reduction interventions. The proposed research will provide a more complete measure of chemical exposures from WUI fires and associated health effects, and inform exposure prevention measures.

PI_NAMEs: BURGESS, JEFFEREY L. (contact)

PROGRAM_OFFICER_NAME: O'FALLON, LIAM

PROJECT_TERMS: Acute;acute toxicity;Aldehydes;Animals;Aromatic Polycyclic Hydrocarbons;Back;Benzene;Biological Markers;biomass smoke;Blood;Blood specimen;Burn injury;cancer risk;Carcinogens;Characteristics;Chemical Exposure;chemical reduction;Chemicals;Child;Chronic;climate change;Cohort Studies;Colon Carcinoma;Communication;community engaged research;comparison intervention;Complex Mixtures;Congenital Abnormality;Control Groups;County;Data;Decontamination;Dermal;dermal exposure;Development;Disease;disorder risk;DNA Methylation;Dose;effective intervention;Effectiveness;effectiveness evaluation;Enrollment;Epigenetic Process;Equipment;exposure reduction interventions;Exposure to;Female;Fire - disasters;fire fighter;General Population;Goals;Health;Health Services Research;Human;Hydroxylation;improved;Incidence;Infertility;interest;Intervention;Knowledge;Lead;Los Angeles;male;Malignant neoplasm of prostate;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Measurement;Measures;Melanoma;Mesothelioma;Metabolic;metabolome;metabolomics;MicroRNAs;Monitor;Municipalities;Non-Hodgkin's Lymphoma;novel;Occupational;Occupational Exposure;Oranges;Outcome;ovarian reserve;Particulate;personal protective equipment;Pilot Projects;Population;Premature Birth;Prevention Measures;Public Health;Reporting;reproductive outcome;Research;Research Personnel;response;Risk;Silicones;Smoke;sperm cell;Spontaneous abortion;steroid hormone;Structure;Taurine;Testing;Testis;Time;Toxic effect;Trust;Tryptophan;United States;urinary;Urine;Volatilization;Wildfire;wood smoke;Work;Wrist;wristband

PROJECT_TITLE: Wildland-Urban Interface Fire Exposures, Effects, and Interventions: A Collaborative Research-to-Action Partnership with Firefighters

STUDY_SECTION: SEDH

STUDY_SECTION_NAME: Social and Environmental Determinants of Health Study Section[SEDH]


NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: PROJECT NARRATIVE Mount Sinai PREP seeks to increase the participation of individuals from underrepresented minority groups and socioeconomically disadvantaged individuals at the cutting-edge levels of biomedical research, and seeks to accommodate individuals with disabilities. Research shows that diverse groups function more effectively and innovatively than groups lacking diversity. Major benefits to public health will result from further diversification of the biomedical work-force and a diverse work-force will increase engagement and expert focus on problems related to health and health care disparities, which are in need of such focus.

PI_NAMEs: CAMPBELL, KIRK N (contact);SLY, JAMILIA RAKI;SOBIE, ERIC A

PROJECT_TERMS: Advisory Committees;Area;Award;Awareness;Biological Sciences;Biomedical Research;biomedical scientist;Brothers;career;career development;career networking;cohort;college;Communicable Diseases;Communication;Communities;Data;design;Development;Development Plans;disability;Disabled Persons;disadvantaged background;Discipline;Diverse Workforce;Doctor of Philosophy;drug development;Economically Deprived Population;Education;education research;Educational workshop;Electronic Mail;Engineering;Enrollment;Evaluation;experience;Faculty;faculty research;Feedback;Fellowship;Funding;Goals;graduate school;Grant;Health;health care disparity;improved;Individual;innovation;Institution;interest;Journals;Kidney;Laboratories;laboratory experiment;Life;Logic;Maintenance;Medical;medical schools;meetings;member;Mentors;Mentorship;Minority Groups;Mission;Modeling;Monitor;multidisciplinary;National Institute of Allergy and Infectious Disease;National Institute of General Medical Sciences;novel;Occupational activity of managing finances;Outcome;outreach;Participant;peer;peer coaching;Personal Satisfaction;Positioning Attribute;Postbaccalaureate;Postdoctoral Fellow;pre-doctoral;Process;Program Development;Program Evaluation;programs;prospective;psychosocial wellbeing;Public Health;recruit;Research;Research Training;Residencies;Resources;Scholars Program;Science;Scientist;Self-Examination;Services;Sister;skills;social;socioeconomic disadvantage;Structure;Students;success;symposium;Technical Expertise;technological innovation;tool;Touch sensation;Traineeship;Training;Training Activity;Training Programs;undergraduate research experience;Underrepresented Minority;United States National Institutes of Health;Universities;Visit;Work;Writing;Youth

PROJECT_TITLE: Postbaccalaureate Research Education Program (PREP)

STUDY_SECTION_NAME: Training and Workforce Development Study Section - C[TWD-C]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Chronic Liver Disease and Cirrhosis;Clinical Research;Dietary Supplements;Digestive Diseases;Liver Disease;Prevention;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PHR: PROJECT NARRATIVE Drug-induced liver injury (DILI) is a serious adverse drug reaction that can occur with the use of many prescription and non-prescription medications and lead to mild-to-severe liver damage. DILI is a leading cause of acute liver failure and the most common reason for drug recalls. This project seeks to develop a next- generation, animal-free human DILI risk prediction platform through human liver tissue engineering and the development of a microfluidic organ-on-a-chip. Results from this study could improve DILI risk prediction and may ultimately lead to the development of safer and more effective medications and identify potential strategies to treat DILI.

PI_NAMEs: FONTANA, ROBERT J;SEXTON, JONATHAN ZACHARY (contact)

PROGRAM_OFFICER_NAME: KODURI, SAILAJA

PROJECT_TERMS: 3-Dimensional;acute liver disease;Acute Liver Failure;adverse drug reaction;Amoxicillin;Amoxicillin-Potassium Clavulanate Combination;Animals;biobank;Biological Assay;Biological Markers;Blinded;Cell Communication;Cell Line;Cell Physiology;cell type;Cells;Cessation of life;cholangiocyte;chronic liver disease;Clavulanate;clinical risk;clinical trial participant;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;Coculture Techniques;Coupled;CRISPR interference;cytokine;deep learning;Development;dietary supplements;disease phenotype;Dose;drug development;Drug Exposure;drug induced liver injury;Drug Modelings;Drug Prescriptions;Drug Recalls;Drug Screening;Drug usage;Endothelial Cells;Endothelium;Engineering;Enrollment;ethnic diversity;Etiology;experience;exposed human population;Exposure to;Failure;FDA approved;gender diversity;Gene Expression Profile;genetic risk factor;genome editing;Genotype;Hepatocyte;Hepatotoxicity;Herbal supplement;Human;human induced pluripotent stem cells;Immune;improved;In Vitro;induced pluripotent stem cell;insight;Link;Liver;Liver Failure;liver injury;Macrophage;Marketing;Metabolism;metabolomics;Methods;Microfluidic Microchips;Microfluidics;microphysiology system;Modeling;Molecular;Morphology;National Institute of Diabetes and Digestive and Kidney Diseases;next generation;novel;organ on a chip;Organoids;Paint;participant enrollment;Pathogenesis;patient derived induced pluripotent stem cells;Patients;peripheral blood;Peripheral Blood Mononuclear Cell;Pharmaceutical Preparations;Phenotype;Physiological;Predisposition;Prospective Studies;Public Health;Qualifying;Reporting;response;Risk;risk prediction;Sensitivity and Specificity;single-cell RNA sequencing;stellate cell;Symptoms;System;Technology;Testing;Tissue Engineering;Tissues;transcriptomics;Transplantation;Trimethoprim-Sulfamethoxazole;United States;Withdrawal

PROJECT_TITLE: Modeling Drug Induced Liver Injury with Patient-Derived Liver Organoids and Microfluidic Chips

STUDY_SECTION: DBDT

STUDY_SECTION_NAME: Drug and Biologic Disposition and Toxicity Study Section[DBDT]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Genetics;Human Genome;Mental Health;Neurosciences;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: DALLAS

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: Project Narrative This project will generate three atlases that describe the molecular signatures, anatomical phenotypes, and three-dimensional distribution of mouse spinal cord cell types over developmental time. These rich datasets will serve as a fundamental resource for the spinal cord field and address a long-standing gap in knowledge linking adult cell types to their developmental lineage. The atlases will focus on cell types that mediate somatosensation and thus, lay important groundwork for cataloging spinal cell types in native states that can be compared to injured or diseased states, referenced to other species, and used for cell-type regeneration and engineering efforts of spinal cord tissue.

PI_NAMEs: LAI, HELEN  (contact)

PROGRAM_OFFICER_NAME: YAO, YONG

PROJECT_TERMS: 3-Dimensional;Address;Adult;analysis pipeline;Anatomy;Animals;Archives;Area;ATAC-seq;Atlases;Biological Assay;body position;Cataloging;Catalogs;Cell Nucleus;Cell Physiology;Cell Separation;cell type;Cells;Cerebellum;Cervical;Chest;Chromatin;Communities;Coupled;Data;Data Set;Databases;Development;Disease;Dorsal;Embryo;Embryonic Development;embryonic stem cell;Engineering;Epigenetic Process;epigenome;epigenomics;Fluorescence-Activated Cell Sorting;Foundations;Genes;Genetic;Genetic Transcription;Genomics;Goals;Histologic;Histological Techniques;Human;Image;Imaging technology;Immunohistochemistry;Individual;injured;innovative technologies;insight;Knowledge;Limb structure;Link;Location;Mediating;Modeling;Molecular;Molecular Profiling;mouse Cre recombinase;multiple omics;Mus;Natural regeneration;Neurons;Neurosciences;Nociception;Nuclear;Nuclear RNA;Organism;parabrachial nucleus;Phenotype;progenitor;Proprioception;Pruritus;Research Personnel;Resources;Sampling;single nucleus RNA-sequencing;somatosensory;Spatial Distribution;Specific qualifier value;Spinal;Spinal Cord;Stimulus;success;Technical Expertise;Techniques;Temperature;Thalamic structure;Time;time use;Tissues;Touch sensation;Transcript;transcription factor;transcriptome sequencing;transcriptomics

PROJECT_TITLE: Molecular and anatomical atlases from progenitors to adult neurons in the mouse spinal cord

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-L (06)]


ED_INST_TYPE: SCHOOLS OF PHARMACY

PHR: PROJECT NARRATIVE Despite the rapid growth of antibody-based drugs, challenges limiting their success as a therapeutic class persist, including the development challenges of high attrition rates and the therapeutic challenge of heterogeneous benefit across patient populations. A key driver of these issues is our poor understanding of antibody pharmacology across biological contexts, and antibody therapeutics frequently fail in translation when their mechanism of action cannot keep up with the diverse and dynamic biological contexts and tissue environments. Our research has focused on developing systems modeling methods and spatiotemporally-resolved molecular imaging tools to investigate antibody pharmacology across biological contexts and resolve issues that hinder the development and application of antibody drugs.

PI_NAMEs: CAO, YANGUANG  (contact)

PROJECT_TERMS: Address;Animals;Antibodies;Antibody Therapy;Binding;Biological;Biological Models;Bioluminescence;Biophysics;Cell Communication;Cell model;Cells;cellular imaging;Coupled;Data;design;Development;Dimensions;Disease;drug development;Drug Kinetics;Energy Transfer;Environment;Exhibits;imaging approach;Imaging Device;Imaging technology;Immune;Immunoglobulin Constant Region;immunological status;in vivo;insight;Mathematics;Measures;Mediating;Methods;Modeling;molecular imaging;neglect;Pathology;patient population;patient subsets;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;Pharmacologic Actions;Pharmacology;Physiological;Physiology;Process;rapid growth;Research;Role;spatiotemporal;success;System;Therapeutic;Therapeutic antibodies;therapeutic development;Tissues;tool;Translations;Variant;Work

PROJECT_TITLE: Quantitative Systems Pharmacology of Antibody Therapeutics across Diverse Biological Contexts

STUDY_SECTION: MRAD

STUDY_SECTION_NAME: Maximizing Investigators' Research Award - D Study Section[MRAD]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

ORG_CITY: PHILADELPHIA

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: THOMAS JEFFERSON UNIVERSITY

ORG_STATE: PA

PHR: Project Narrative  Dynamic RNA modifications have emerged as an exciting new mechanism of post-transcriptional regulation of gene expression. We propose a nanopore RNA sequencing strategy that will read an RNA modification twice, first through the copied strand and then the template strand, where the copied strand provides the “ground truth” for the modification in the template strand. This 2-read strategy will improve reading RNA modifications with accuracy and quantification to facilitate investigation of their important roles in human health and disease.

PI_NAMEs: HOU, YA-MING  (contact)

PROGRAM_OFFICER_NAME: NOVA, IAN CURTIS

PROJECT_TERMS: Address;algorithm development;Anti-sense RNA;Area;Back;Biological;Biology;Cells;Collaborations;Complementary DNA;Data;Data Set;deep learning model;Disease;DNA-Directed RNA Polymerase;Endowment;Enzymatic Biochemistry;Enzymes;flexibility;Gene Expression;Gene Expression Regulation;Generations;Genetic Transcription;Genome;Goals;Health;Human;Human poliovirus;improved;In Vitro;insight;interest;Investigation;Libraries;Link;Machine Learning;Maps;Measures;Messenger RNA;Modification;nanopore;Nucleic acid sequencing;Nucleotides;Positioning Attribute;Post-Transcriptional Regulation;Pseudouridine;Reader;Reading;Reagent;Replication Initiation;Reporting;Research;Resolution;RNA;RNA analysis;RNA replication;RNA-Directed DNA Polymerase;RNA-Directed RNA Polymerase;Role;sequencing platform;Series;Site;Speed;Structure;Technology;technology platform;telomere;Testing;Time;tool;Transcript;transcriptome;transcriptome sequencing;Untranslated RNA;Validation;Variant;viral RNA;Work

PROJECT_TITLE: Twice reading of RNA by direct nanopore sequencing

STUDY_SECTION_NAME: Special Emphasis Panel[ZHG1 HGR-M (O2)]


NIH_SPENDING_CATS: Behavioral and Social Science

ORG_CITY: CHICAGO

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF CHICAGO

PHR: PROJECT NARRATIVE The long-range goal of the University of Chicago Post-Baccalaureate Research Education Program (PREP) is to help diversify the scientific workforce. The PREP provides mentored research experiences and academic enhancements in the form of skill-building workshops and courses, with the aim of preparing members of groups underrepresented in the biomedical and behavioral sciences for admission to PhD (or MD/PhD) programs at competitive research institutions. To assess the success of this endeavor, the participants’ progress will be followed throughout their graduate programs and subsequent career path.

PI_NAMEs: CARRILLO, ROBERT ARNULFO;RANDALL, GLENN C;SCHWARTZ, NANCY B (contact)

PROJECT_TERMS: Achievement;Address;Admission activity;Area;Articulation;aspirate;Attitude;Behavioral Sciences;Biomedical Research;biomedical scientist;career;Career Choice;Career Mobility;Chicago;college;Communication;Communities;Competence;Credentialing;Critical Thinking;Data Analyses;Decision Making;design;Development;Development Plans;Doctor of Philosophy;Education;education research;Educational Curriculum;Educational workshop;effectiveness evaluation;effectiveness measure;Eligibility Determination;empowerment;Enrollment;Environment;Ethics;Evaluation;experience;Exposure to;faculty mentor;Familiarity;Feedback;flexibility;Fostering;Future;Goals;graduate school;graduate student;Growth;improved;Individual;Institution;interest;Intervention;Investments;Journals;Laboratories;Learning;matriculation;Measures;member;Mentors;Mentorship;Mission;operation;Oral;oral communication;Outcome;Participant;peer;peer coaching;Postbaccalaureate;Preparation;programs;Qualifying;Readiness;Records;Research;Research Personnel;Research Training;Scholars Program;Science;Scientist;Self Efficacy;skills;Societies;Structure;Student recruitment;success;symposium;Testing;Time;Training;Training and Education;Training Programs;undergraduate student;Underrepresented Populations;United States National Institutes of Health;Universities;Visualization;Work;Writing

PROJECT_TITLE: The University of Chicago PREP


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cystic Fibrosis;Gene Therapy;Genetics;Lung;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: The proposed research is relevant to public health because genetic and acquired diseases affecting the airways pose major disease and economic burdens. Small molecule CFTR potentiators or correctors have provided groundbreaking improvements in the quality of life for most people with CF; however, these drug treatments are not cures and provide no benefit to the ~10% of CF patients with nonsense CFTR mutations. Unlike small molecule potentiators or correctors, a CFTR gene editing approach is potentially a single dose, life-long curative therapeutic strategy for many people with CF.

PI_NAMEs: MCCRAY, PAUL B;SINN, PATRICK L (contact)

PROGRAM_OFFICER_NAME: LACHOWICZ-SCROGGINS, MARRAH ELIZABETH

PROJECT_TERMS: Address;Adenine;adeno-associated viral vector;adenosine deaminase;Affect;Air;airway epithelium;Animals;Area;Basal Cell;base editing;base editor;bioelectricity;bioluminescence imaging;Bronchi;burden of illness;Capsid;Categories;cell type;Cells;Chlorides;Clustered Regularly Interspaced Short Palindromic Repeats;Control Animal;CRISPR/Cas technology;curative treatments;cystic fibrosis airway;cystic fibrosis patients;Cystic Fibrosis Transmembrane Conductance Regulator;Data;Daughter;delivery vehicle;Dependovirus;Disease;DNA cassette;DNA Double Strand Break;Dose;Economic Burden;Electroporation;Endonuclease I;Engineering;Epithelial Cells;Ethmoid sinus structure;Event;Exons;experimental study;Family suidae;functional restoration;Gene Delivery;gene editing technology;Gene Modified;gene repair;gene therapy;gene-editing approach;Genes;Genetic;Genome;Glycoproteins;Goals;Goblet Cells;Guanine;Guide RNA;Head;homologous recombination;Human;improved;In Situ;In Vitro;in vivo;in vivo Model;Inbred CFTR Mice;Inflammation;intein;Interleukin-13;Interphase Cell;Knock-in;Knowledge;Length;Liquid substance;Lung;Lung Diseases;Mediating;Mendelian disorder;Metaplasia;methacholine;Methods;Microscopy;Modeling;mouse model;Mucins;Mucolytics;Mucous body substance;Mus;Mutation;next generation sequencing;Nonsense Codon;Nonsense Mutation;Nose;nuclease;Organ;particle;Persons;Pharmaceutical Preparations;Pharmacotherapy;porcine model;Production;Proteins;Public Health;Quality of life;Reagent;repair strategy;repaired;Reporter;Reporter Genes;Reporting;Research;Ribonucleoproteins;Rodent;Site;small molecule;stem;stem cells;Study models;success;Surface;Testing;Therapeutic;tool;Trachea;Transgenic Organisms;Tropism;uptake;Variant;vector;Viral;Viral Vector;Virus-like particle;Western Blotting;Zinc Fingers

PROJECT_TITLE: Adenine Base Edited Correction of Cystic Fibrosis Airways

STUDY_SECTION: DBTD

STUDY_SECTION_NAME: Drug and Biologic Therapeutic Delivery Study Section[DBTD]


ORG_CITY: CAMBRIDGE

ORG_DEPT: CHEMISTRY

ORG_NAME: HARVARD UNIVERSITY

PHR: Project Narrative In this project, we propose to develop and apply spatially resolved single-cell transcriptomics and epigenomics methods to classify cell types and states, map their spatial organization, and determine cell-type-specific cell- cell interactions in the human brain. Our results will provide fundamental insights into the structure and function of the human brain at the molecular and cellular level. The technological innovations and scientific results obtained from this project can also be applied to understand brain diseases and aging.

PI_NAMEs: ZHUANG, XIAOWEI  (contact)

PROJECT_TERMS: 3-Dimensional;Age;Aging;aging brain;Architecture;area striata;Atlases;Basal Ganglia;Binding;Brain;Brain Diseases;BRAIN initiative;Brain Mapping;Brain region;Cell Communication;cell type;Cells;Centenarian;Classification;Complement;Complex;DNA Modification Process;Elderly;epigenomics;Fluorescent in Situ Hybridization;Gene Expression;Gene Expression Profiling;Genes;Genetic Fingerprintings;Genetic Transcription;Genomics;Globus Pallidus;Goals;histone modification;Human;Hypothalamic structure;Image;imaging modality;improved;In Situ;Individual;Inflammatory Response;insight;Maps;Measurement;Measures;meter;Methods;Molecular;Motor Cortex;Multimodal Imaging;multimodality;multiple omics;Nature;Nerve Degeneration;Neuroglia;Neurons;Pattern;Prefrontal Cortex;Preoptic Areas;single cell genomics;Slice;Speed;Structure;Structure of middle temporal gyrus;Structure of subthalamic nucleus;Substantia nigra structure;technological innovation;Technology;technology development;Thick;Thinness;Tissue Sample;Tissues;transcriptome;transcriptomics;two-dimensional

PROJECT_TITLE: Spatial genomics and cell atlas of the human brain


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cardiovascular;Clinical Research;Comparative Effectiveness Research;Dementia;Health Services;Hypertension;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Patient Safety;Prevention

PHR: PROJECT NARRATIVE Despite their low cost and high level of safety, it is still unclear whether antihypertensive and statin therapy prevent Alzheimer’s disease and related dementias because randomized trials have provided mixed results and were often limited by short follow-up times, low statistical power, and a lack of representativeness for the broader population and routine care. Along with machine-learning techniques for heterogeneous treatment effect estimation, this project will apply a novel and well-validated method in large-scale electronic health record data from the US, UK, and Denmark to obtain causal evidence on the effects of antihypertensive and statin therapy on the incidence of Alzheimer’s disease and related dementias. In doing so, we aim to inform clinical and public health guidelines as well as directions for research on dementia prevention, and ultimately encourage similar efforts in other areas of medicine where our approach can be applied.

PI_NAMEs: GELDSETZER, PASCAL  (contact)

PROGRAM_OFFICER_NAME: GHALEH, MARYAM X

PROJECT_TERMS: Adherence;Affect;Alzheimer's disease diagnosis;Alzheimer's disease related dementia;Alzheimer's disease risk;Anti-Hypertensive Agents;Area;Attenuated;Award;Behavior assessment;Behavioral;Blood Pressure;Body mass index;Cardiovascular Diseases;cardiovascular disorder risk;Characteristics;Clinical;clinical practice;Clinical Trials;cost;Data;Data Set;Decision Making;Dementia;dementia risk;Denmark;Development;Diagnosis;dietary;Dose;Effectiveness;Electronic Health Record;Event;follow-up;Future;Glycosylated Hemoglobin;Guidelines;Habits;Health Care Visit;Health system;Incidence;innovation;Integrated Health Care Systems;Intervention;Knowledge;Lead;Low-Density Lipoproteins;Machine Learning;Measurement;Medicare claim;Medicine;Methods;Modernization;Nature;novel;novel strategies;Observational Study;Outcome;patient subsets;Patients;Pharmaceutical Preparations;Pharmacy facility;Physical activity;Population;prevent;Prevention;preventive intervention;Probability;Provider;Public Health;Randomized;randomized trial;Records;Research;Risk;routine care;Safety;Sample Size;Subgroup;Techniques;treatment effect;Triglycerides;United States National Institutes of Health;validation studies

PROJECT_TITLE: The effect of antihypertensive and statin therapy on dementia incidence: a novel analytical approach in large electronic health record datasets with long follow-up times and minimal loss to follow-up

STUDY_SECTION: NMBH

STUDY_SECTION_NAME: Neurological, Mental and Behavioral Health Study Section[NMBH]


ORG_CITY: SANTA CRUZ

ORG_NAME: UNIVERSITY OF CALIFORNIA SANTA CRUZ

PHR: Narrative The biomedical research community at UC Santa Cruz has played a leading role in broadening participation in pre-graduate and graduate research training programs. Through extensive programming and various support services based on best practices, we create an inclusive and equitable environment for underrepresented students to succeed in attaining higher degrees in the biomedical field. With this PREP proposal, we will broaden training opportunities for recent graduates so that they will be able to gain admission to and complete a top-ranked Ph.D. program.

PI_NAMEs: SULLIVAN, WILLIAM T. (contact)

PROJECT_TERMS: Academia;Admission activity;African American;aluminum sulfate;Applications Grants;Area;Award;Bachelor's Degree;Biological Sciences;Biomedical Research;broadening participation research;career;cohort;Collaborations;Communication;Communities;Country;Development;Development Plans;Discipline;Doctor of Philosophy;Educational process of instructing;Educational workshop;Engineering;Enrollment;Ensure;Environment;Equity;Ethical Issues;experience;Experimental Designs;Faculty;faculty mentor;falls;Feedback;Fellowship;Female;First Generation College Students;Fostering;Future;Goals;Government;graduate school;graduate school preparation;Grant;hands on instruction;Hispanic;improved;Industry;Instruction;interest;Interview;Leadership;Learning;lectures;Letters;Literature;male;marginalization;marginalized population;matriculation;member;Mentors;Minority Groups;Mission;Native Americans;Oral;oral communication;Paper;peer;Peer Review;Personality;physical science;Play;Positioning Attribute;Postbaccalaureate;posters;Preparation;Program Development;programs;Publications;Reading;Recommendation;recruit;Research;Research Ethics;Research Institute;Research Personnel;Research Project Grants;Research Training;Resources;responsible research conduct;Role;Schedule;Schools;Science;Secure;Services;skills;southeast Asian;student training;Students;success;Technology;Training;training opportunity;Training Programs;undergraduate student;Underrepresented Minority;Underrepresented Students;underserved minority;United States National Institutes of Health;Universities;Visit;Work;Writing

PROJECT_TITLE: UC Santa Cruz PREP


FUNDING_MECHANISM: SBIR-STTR RPGS

ORG_CITY: SAN DIEGO

ORG_NAME: ELECTRONIC BIOSCIENCES, INC.

PHR: Project Narrative The technology developed during this project will enable direct, true single-molecule, high-accuracy RNA sequencing, including the ability to identify specific modifications thereof, all via the unprecedented ability to iteratively read a given RNA molecule. Enabling accurate transcriptomic and epitranscriptomic investigations via a single technology will be a significant advancement relative to current state-of-the-art technology in the field, which presently requires a combination of techniques and/or chemical reactions that even then cannot fully access the range of nucleotide modifications. Ultimately, an ultra-high-accuracy RNA sequencing technology that can reliably distinguish canonical and modified nucleotides within a RNA strand will propel transcriptomics and epitranscriptomics research and developments into the future and directly enable the associated RNA-based diagnostics, prognostics, and therapeutic intervention.

PI_NAMEs: SCHIBEL, ANNA  (contact)

PROJECT_TERMS: Back;base;Benchmarking;Biological;chemical reaction;ChIP-seq;Computer software;Consensus Sequence;cost;Data;Detection;Diagnostic;Diameter;Diffusion;DNA sequencing;Enzymes;epitranscriptomics;Evaluation;Exclusion;Future;Goals;Hemolysin;Individual;instrumentation;Investigation;Length;Ligation;Lipid Bilayers;Magnetism;Measurement;meter;Methodology;Methods;Modification;Motion;Motor;nanoparticle;nanopore;Nucleotides;particle;Phase;prevent;Procedures;Process;prognostic;programs;Proteins;Pseudouridine;Reader;Reading;research and development;Reverse Transcription;Risk Reduction;RNA;RNA Sequences;Sampling;Scheme;Sequence Determination;sequencing platform;single molecule;Small Business Innovation Research Grant;Stretching;System;Systems Integration;Techniques;Technology;Therapeutic Intervention;Third Generation Sequencing;Time;transcriptome sequencing;transcriptomics;voltage

PROJECT_TITLE: Re-Reading RNA to Obtain High Accuracy


ADMINISTERING_IC: MD

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Patient Safety;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: CORAL GABLES

ORG_NAME: UNIVERSITY OF MIAMI CORAL GABLES

PHR: Project Narrative This proposed training program will address HD by diversifying the pipeline of HD researchers and by increasing this workforce’s competencies in implementing culturally informed, rigorous, and ethically responsible approaches to research. Ultimately, this training program aims to contribute to HD science by helping to prepare a new generation of ethnically diverse HD scientists who will make discoveries that can be translated into interventions to eliminate HD locally and globally.

PI_NAMEs: ORTEGA, JOHIS  (contact)

PROGRAM_OFFICER_NAME: BICKHAM-WRIGHT, UTIBE RONALD

PROJECT_TERMS: Address;Agreement;career;career preparation;Collaborations;Colombia;Costa Rica;Country;Discipline of Nursing;Doctor of Philosophy;Dominican Republic;Educational workshop;experience;Funding;Future;global health;Goals;graduate school;Health;Health Disparities Research;health disparity;health disparity populations;Health Professional;Human Resources Development;improve minority health;Individual;Institution;Jamaica;Journals;Latino;Manuscripts;Mentors;Mexico;minority health;minority health disparity;minority student;National Institute on Minority Health and Health Disparities;Outcome;Pan American Health Organization;patient safety;Peer Review;Peru;Positioning Attribute;Process;programs;Publications;Reduce health disparities;Research;research data dissemination;Research Institute;Research Personnel;Research Project Grants;Research Training;School Nursing;Science;Scientist;Students;success;summer research;Time;Training;Training Programs;Universities;Work;Writing

PROJECT_TITLE: Training Future Scientists to Address Global Health Disparities


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Mental Health;Neurodegenerative;Neurosciences;Prevention;Rehabilitation

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

PHR: NARRATIVE Most delirium treatments developed to date have been ineffective in improving outcomes such as accelerated cognitive decline, because they modify risk factors for delirium development and are uniformly administered to all patients 24 to 48 hours after admission. We propose this randomized control trial to determine if early (<24 hours) cognitive training and rehabilitation improve 6-month global cognition in older delirious patients with and without Alzheimer’s disease and related dementias. To identify patients who may benefit more from the cognitive intervention, we will also perform latent class analysis to identify novel delirium phenotypes, and determine if they modify the relationship between the cognitive intervention and 6-month global cognition.

PI_NAMEs: HAN, JIN HO (contact);JACKSON, JAMES C.

PROGRAM_OFFICER_NAME: ROBERTS, LUCI

PROJECT_TERMS: Acceleration;Accident and Emergency department;Acute;Acute Brain Injuries;acute coronary syndrome;Address;Admission activity;Adult;adverse outcome;Affect;Alzheimer's disease patient;Alzheimer's disease related dementia;Arousal;Biological Markers;Blood brain barrier dysfunction;Brain;Central Nervous System;Classification;Cognition;Cognitive;cognitive control;Cognitive deficits;cognitive rehabilitation;cognitive task;cognitive training;Complex;Data;Delirium;design;Development;Early identification;Effectiveness of Interventions;efficacious intervention;endothelial dysfunction;Enrollment;Etiology;Exercise;Failure;Family;Foundations;Functional disorder;Functional Magnetic Resonance Imaging;Future;Goals;Heterogeneity;high risk;Hospitalization;Hospitals;Hour;Impaired cognition;improved;improved outcome;Injury;innovation;Intervention;Metabolic;Methods;Modification;neuronal survival;Neurons;novel;novel strategies;older patient;Outcome;Patients;Phenotype;Pilot Projects;Play;preservation;prevent;Randomized;Randomized, Controlled Trials;Rehabilitation therapy;Reporting;Risk Factors;Role;Sample Size;Sepsis;Serum;Severities;skill acquisition;Stroke;Symptoms;Syndrome;systemic inflammatory response;Techniques;treatment as usual;trial design;Work

PROJECT_TITLE: Early Cognitive Training and Rehabilitation to Prevent Cognitive Decline in Older Hospitalized Adults with Delirium


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Brain Cancer;Brain Disorders;Cancer;Neurosciences;Rare Diseases

ORG_CITY: BLACKSBURG

ORG_DEPT: MISCELLANEOUS

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

ORG_STATE: VA

PHR: Narrative Invasion in glioblastoma is a major contributor to poor prognosis. We have identified interstitial fluid flow across the invasive edge of tumors to stimulate glioma cell invasion through effects on cancer cells and the surrounding microenvironment. Here we will probe the nature and effects of interstitial fluid flow in glioma invasion and identify new targets and strategies against this deadly disease

PI_NAMEs: MUNSON, JENNIFER M (contact)

PROGRAM_OFFICER_NAME: ZHANG, HUIMING

PROJECT_TERMS: 3-Dimensional;Affect;Algorithmic Analysis;Angiogenesis Inhibitors;Area;Astrocytes;Autologous;Automobile Driving;Brain;Brain Neoplasms;brain parenchyma;Brain region;brain tissue;cancer cell;CCL21 gene;Cell Line;Cells;chemokine;chemokine receptor;Chemotaxis;clinically relevant;Coculture Techniques;Computer Models;computerized tools;contrast enhanced;Contrast Media;Correlative Study;CXCL5 gene;CXCR4 gene;Disease;experimental study;Extracellular Matrix;Fibroblasts;fluid flow;Gene Expression;Genetic Engineering;Glioblastoma;Glioma;Grant;Image;Imaging Device;Implant;In Vitro;in vitro Assay;in vivo;in vivo Model;inhibitor;Intercellular Fluid;interstitial;Invaded;Knock-out;Liquid substance;Magnetic Resonance Imaging;Malignant Breast Neoplasm;Malignant neoplasm of brain;Maps;Measurement;Measures;mechanical force;Mediating;Methodology;Methods;Microarray Analysis;Microfluidics;Microglia;Modality;Modeling;mouse model;Mus;Nature;neoplastic cell;Neuroglia;novel;Outcome;overexpression;Pathway interactions;Patients;Pattern;Physiological;Population;pressure;Prevalence;Prognosis;Radiation therapy;receptor;Recurrence;Reporter;Reporting;response;Role;Route;Signal Transduction;small molecule;Sphingosine-1-Phosphate Receptor;stem cells;Stromal Cell-Derived Factor 1;Stromal Cells;System;Techniques;Testing;Therapeutic;Time;Tissue Engineering;Tissues;treatment response;tumor;tumor growth;tumor microenvironment;Up-Regulation;Work;Xenograft procedure

PROJECT_TITLE: Interstitial Fluid Flow Regulates Glioma Cell Invasion


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Endocrine Disruptors;Estrogen;Health Effects of Indoor Air Pollution;Mental Health;Mental Illness;Neurosciences;Pediatric

ORG_CITY: PISCATAWAY

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: RUTGERS, THE STATE UNIV OF N.J.

ORG_STATE: NJ

PHR: Project Narrative Developmental exposure to endocrine disrupting compounds such as organophosphate flame retardants (OPFRs) may disrupt cognitive processing in the adult offspring. It is well known that chronic stressful experiences can result in maladaptive states that impair learning and memory processes in both rodents and humans. The combination of developmental OPFR exposure and adult chronic stressors may further exacerbate cognitive impairment.

PI_NAMEs: WIERSIELIS, KIMBERLY ROBYN (contact)

PROGRAM_OFFICER_NAME: HOLLANDER, JONATHAN

PROJECT_TERMS: Acetylcholine;Adolescent;Adult;Adult Children;Animal Model;Animals;approach/avoidance behavior;Award;Beds;behavior measurement;behavior test;Behavioral;behavioral response;Brain;Brain Diseases;Brain region;Chemical Exposure;Chronic;Chronic stress;Cognition;Cognitive;cognitive testing;Corticotropin-Releasing Hormone;CRH gene;Decision Making;Dendritic Spines;density;Development;Disease;Dopamine;Electrophysiology (science);Endocrine Disruptors;environmental chemical;Estrogen Receptors;Exposure to;Faculty;Female;Flame Retardants;Gene Expression;Genes;Goals;Golgi Apparatus;High Pressure Liquid Chromatography;Hippocampus;hormonal signals;Human;human model;Hypothalamic structure;Immunohistochemistry;Impaired cognition;Impairment;Individual;Institution;Interneurons;Knowledge;Learning;Life;Link;Literature;Long-Term Potentiation;Major Depressive Disorder;male;Maternal Exposure;Measurement;Measures;Memory;memory process;Mental Depression;Mental disorders;Modeling;Moods;Morphology;Motor Activity;mouse development;Mus;Muscarinics;Neonatal;neural circuit;Neurologic;Neurons;Neurotransmitters;Norepinephrine;novel;Nuclear;Nuclear Receptors;object recognition;offspring;optogenetics;Organophosphates;Pathology;Perinatal;Perinatal Exposure;Phase;Positioning Attribute;postnatal;Prefrontal Cortex;Pregnancy;programs;Receptor Signaling;Research;Rodent;Role;Schizophrenia;Secure;Signal Transduction;sound;Steroid Receptors;Stress;Stressful Event;stressor;Symptoms;Synaptic Transmission;Testing;Toxic effect;toxicant;Training;Training Programs;Vertebral column;Work

PROJECT_TITLE: The interaction of perinatal organophosphate flame retardant exposure and adult chronic stress on cognitive processing


NIH_SPENDING_CATS: Breast Cancer;Cancer;Women's Health Research

ORG_CITY: CLEVELAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

PHR: PROJECT NARRATIVE Triple Negative Breast Cancer (TNBC) is a highly aggressive disease that has limited treatment options. This proposal focuses on determining if a protein called YES1 may underlie the malignancy associated with TNBC and the molecular pathways it uses to cause poor patient outcomes. This work will also provide a proof-of- concept in model systems testing the possibility of inhibiting YES1 with drugs that may ultimately lead to a more effective approach for treating TNBC.

PI_NAMEs: KERI, RUTH A. (contact)

PROGRAM_OFFICER_NAME: XU, WANPING

PROJECT_TERMS: Adhesions;Architecture;Automobile Driving;Biological Models;Breast Cancer Cell;Breast Cancer Patient;cancer initiation;cell growth;Cell Nucleus;Cell Survival;chemotherapy;Chromosomal Instability;Collection;Coupled;Cytotoxic Chemotherapy;Data;Defect;differential expression;Disease;drug efficacy;Drug Targeting;Ensure;Epidermal Growth Factor Receptor;Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor;ERBB2 gene;Estrogens;Event;expectation;extracellular;Family;Family member;Functional disorder;Gamma-H2AX;Genome Stability;Genomic Instability;Genomics;Goals;Growth;Heat-Shock Proteins 70;Heterogeneity;improved;Individual;inhibitor;innovation;insight;live cell imaging;Malignant Breast Neoplasm;Malignant Neoplasms;Mediating;Metastatic/Recurrent;micronucleus;Mitosis;Mitotic;Molecular;Molecular Chaperones;Motility;neoplastic cell;new therapeutic target;novel;novel therapeutic intervention;Nuclear;Oncogenic;Outcome;overexpression;Pathway interactions;patient derived xenograft model;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;Phosphotransferases;Play;Precision therapeutics;Process;Progesterone;Proliferating;Protein Tyrosine Kinase;Proteins;receptor;receptor expression;Receptor Signaling;refractory cancer;Reporting;Resistance;response;restoration;Role;Signal Pathway;Signal Transduction;src-Family Kinases;survivorship;targeted treatment;taxane;Testing;Therapeutic;therapeutic target;Toxic effect;transcription factor;transcriptomics;triple-negative invasive breast carcinoma;tumor;tumor progression;Work;YES1 gene

PROJECT_TITLE: Discovering the role of YES1 in triple negative breast cancer

STUDY_SECTION: TCB

STUDY_SECTION_NAME: Tumor Cell Biology Study Section[TCB]


NIH_SPENDING_CATS: Cancer;Hematology;Lymphatic Research;Lymphoma;Orphan Drug;Rare Diseases

PHR: Narrative Dysregulation of the anti-apoptotic BCL2 family of proteins allows cancer cells to survive. Results from the proposed studies will significantly increase understanding of an understudied BCL2 family member and its contribution to lymphoma survival and resistance to targeted therapies. Our studies will ultimately lead to improved therapeutic targeting for the treatment of lymphomas and likely other malignancies.

PI_NAMEs: EISCHEN, CHRISTINE M. (contact)

PROGRAM_OFFICER_NAME: JHAPPAN, CHAMELLI

PROJECT_TERMS: Apoptosis;Apoptotic;B-Cell Leukemia;B-Cell Lymphomas;B-Lymphocytes;BCL2 gene;BCL2L1 gene;Biological Markers;biomarker identification;Burkitt Lymphoma;cancer cell;Cancer Etiology;cancer therapy;Cell Line;Cell Survival;Clinic;Clinical Trials;Combined Modality Therapy;Development;Diagnostic;experimental study;Family;Family member;Family psychotherapy;FDA approved;Follicular Lymphoma;Genomic approach;Genomics;Hematologic Neoplasms;Human;Human Cell Line;improved;inhibitor;innovation;Investigation;Knowledge;large cell Diffuse non-Hodgkin's lymphoma;leukemia;Link;Lymphoid;Lymphoma;Lymphoma cell;Lymphomagenesis;Malignant Neoplasms;MCL1 gene;Molecular;Monitor;mouse model;Mus;non-genomic;novel;overexpression;Pathway interactions;patient derived xenograft model;Patients;Population;pressure;prognostic;prognostic indicator;Protein Family;Proteins;Resistance;resistance mechanism;Role;Sampling;Scientist;single cell analysis;Spermatogenesis;System;targeted treatment;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;therapy resistant;treatment response;tumor;tumorigenesis

PROJECT_TITLE: BCLW in lymphoma survival and resistance to targeted BCL2 family therapies

STUDY_SECTION: CAMP

STUDY_SECTION_NAME: Cancer Molecular Pathobiology Study Section[CAMP]


ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PUBLIC HEALTH RELEVANCE STATEMENT – Abramson Cancer Center Cancer is the second leading cause of death in the United States and prevalent in the ethnically diverse catchment area of the Abramson Cancer Center (ACC), which consists of 12 contiguous counties in Pennsylvania, New Jersey, and Delaware, in which 81.4% of ACC's patients reside. Through our Research Programs and Community Outreach and Engagement, the ACC addresses the burden imposed by highly prevalent cancers in the catchment area, including breast, prostate, lung, colorectal, melanoma, and lymphoma. ACC basic, clinical, and population science research – along with Community Outreach and Engagement Activities – are integrated to prevent, diagnose, and treat these cancers and address cancer risk factors to promote healthy living.

PI_NAMEs: VONDERHEIDE, ROBERT H (contact)

PROGRAM_OFFICER_NAME: PTAK, KRZYSZTOF

PROJECT_TERMS: Abbreviations;Abramson Cancer Center at the University of Pennsylvania;acronyms;Address;Adult;anti-cancer research;Area;Automobile Driving;Basic Science;behavioral economics;Beverages;biobank;biomedical informatics;Black race;Brain Neoplasms;brca gene;Breast;Cancer Burden;cancer care;Cancer Center;Cancer Center Support Grant;Cancer Control;cancer education;cancer immunotherapy;Cancer Patient;cancer risk;cancer surgery;Capital;Caring;Catchment Area;Cause of Death;Cells;Cellular biology;Child;chimeric antigen receptor;chimeric antigen receptor T cells;Clinical;Clinical Data;clinical investigation;Clinical Investigator;clinical practice;Clinical Protocols;Clinical Research;Clinical Sciences;Clinical Trials;Collaborations;Colorectal;community advisory board;community engagement;Community Outreach;Comprehensive Cancer Center;Country;County;data management;Delaware;Development;Diagnosis;Disease;DNA Damage;Early Diagnosis;Ecosystem;Electronic Health Record;Enrollment;environmental carcinogenesis;environmental toxicology;Epigenetic Process;ethnic diversity;Ethnic Origin;Face;Fostering;Funding;gene therapy;Genetic;Geography;Germ Lines;Health behavior;health care delivery;Health Policy;Health Services Research;Hospitals;Human Papilloma Virus Vaccination;imaging program;Immunology;Immunotherapy;improved;Incidence;innovation;Institution;Intervention Trial;Journals;Laboratories;Leadership;Lung;Lymphoma;Malignant Childhood Neoplasm;Malignant Neoplasms;Manuscripts;medical schools;Medically Underserved Area;Medicine;Melanoma;member;microbiome;Mission;Modernization;molecular imaging;Monitor;Nature;New Jersey;novel strategies;novel therapeutic intervention;Oncogenes;outreach;Paper;patient oriented;Patients;Pediatric Hospitals;Pediatric Oncology Group;Pennsylvania;personalized diagnostics;Philadelphia;Population;population based;Population Research;Population Sciences;prevent;Prevention;Productivity;programs;Prostate;Protocols documentation;Proton Radiation;proton therapy;public health relevance;Publications;Publishing;Radiobiology;radiomics;Recording of previous events;Research;Research Personnel;Resource Sharing;Resources;response;Rest;Risk;Risk Assessment;Risk Factors;Science;Scientist;Services;severe mental illness;Smoking;smoking cessation;survivorship;System;T-Lymphocyte;targeted treatment;tobacco carcinogenesis;tobacco control;Training and Education;Translating;translational medicine;Translational Research;translational scientist;translational therapeutics;Translations;treatment trial;tumor metabolism;tumor microenvironment;Tumor Tissue;Underrepresented Populations;United States;United States National Institutes of Health;Universities;University Hospitals;Vision

PROJECT_TITLE: Abramson Cancer Center Support Grant

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


NIH_SPENDING_CATS: Cancer

PI_NAMEs: WYNNE, ROBERT F. (contact)

PROJECT_TERMS: Abbreviations;acronyms;anti-cancer research;Applications Grants;Cancer Burden;Cancer Center;Cancer Center Support Grant;cancer research center director;Catchment Area;Clinical Data;Clinical Protocols;Clinical Research;Communication;community engagement;Community Outreach;Complex;Comprehensive Cancer Center;data management;Decision Making;Dedications;Development;Ensure;Environment;Evaluation;Event;experience;Goals;Grant;Growth;Institution;interest;International;Lead;Leadership;Legal;medical schools;Medicine;member;Mission;Monitor;Occupational activity of managing finances;operation;Parents;Policies;Process;programs;Reporting;Research;Research Activity;Resource Sharing;Resources;Role;Services;Shapes;Strategic Planning;success;Talents;Training and Education;Universities

PROJECT_TITLE: Cancer Center Administration


NIH_SPENDING_CATS: Cancer;Genetics;Lung;Lung Cancer

ORG_CITY: Newark

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

PHR: Project Narrative Patients harboring mutations in both KRAS and LKB1, two of the most frequent mutations detected in non-small cell lung cancer (NSCLC), develop aggressive lung tumors, show a high frequency of metastases and are resistant to therapeutics. Using genetically engineered mouse models (GEMMs) of KRAS-mutant, LKB1- deficient (KL) NSCLC, we have demonstrated that autophagy is required for KL lung tumor initiation and tumor growth. In this proposal, we will explore the mechanism by which autophagy regulates lipid metabolism for KL tumorigenesis in vivo, determine how autophagy promotes KL tumor metastasis, and identify metabolic bypasses that potentially create resistance to autophagy inhibition in KL NSCLC. Our overall goal is to validate the novel concept that autophagy inhibition is a selective and powerful therapeutic strategy against primary and metastatic KL NSCLC.

PI_NAMEs: GUO, YANXIANG  (contact)

PROGRAM_OFFICER_NAME: SALNIKOW, KONSTANTIN

PROJECT_TERMS: 5'-AMP-activated protein kinase;Ablation;Accounting;Address;Adenocarcinoma;Adenocarcinoma Cell;Alleles;Autophagocytosis;Biological Models;Bypass;cancer cell;Cancer Etiology;Cancer Patient;cancer therapy;Catabolic Process;Cell Proliferation;Cell Survival;Cells;Clinical Trials;Compensation;Essential Genes;exome sequencing;extracellular;fatty acid metabolism;Frequencies;Genes;Genetic Predisposition to Disease;Genetically Engineered Mouse;genome-wide;Goals;Homeostasis;Impairment;improved;In Vitro;in vivo;inducible Cre;inhibition of autophagy;insight;K-ras mouse model;knock-down;KRAS2 gene;KRASG12D;lipid metabolism;loss of function;lung cancer cell;Lung Neoplasms;lung tumorigenesis;Malignant neoplasm of lung;Malignant Neoplasms;Mediating;Metabolic;Metabolic stress;Metabolism;Metastatic Neoplasm to the Lung;mortality;mouse model;Mus;mutant;Mutate;Mutation;Mutation Detection;Neoplasm Metastasis;neoplastic cell;Non-Small-Cell Lung Carcinoma;Normal tissue morphology;novel;Nutrient;Oncogenic;Organelles;Patients;pre-clinical;predictive marker;Process;Prognosis;Property;Proteins;Recycling;Resistance;response;Role;Squamous cell carcinoma;Starvation;STK11 gene;targeted treatment;Testing;Therapeutic;TP53 gene;transdifferentiation;Transition Career Development Award (K22);tumor;tumor growth;tumor initiation;tumor metabolism;tumorigenesis

PROJECT_TITLE: Elucidate the mechanism of autophagy in supporting Lkb1-deficient lung tumorigenesis and metastasis


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Rare Diseases;Stroke;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: Los Angeles

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Relevance to Public Health Cerebral small vessel disease (SVD) is a major cause of stroke, white matter (WM) disease and dementia, but the mechanisms underlying brain damage and cognitive decline remain largely elusive. This US-China Biomedical Research Collaboration project will apply cutting edge MRI technologies in a unique cohort of Chinese patients with genetically defined SVD (NOTCH3 mutation carriers suffering from cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy or CADASIL), to understand the role of blood-brain barrier (BBB) in the initiation and progression of SVD.

PI_NAMEs: WANG, DANNY JJ (contact)

PROGRAM_OFFICER_NAME: YIN, XILING

PROJECT_TERMS: Acceleration;Affect;Age;aging population;Arterial Disorder;arterial spin labeling;Arteries;arteriole;autosome;Biological Markers;Biomedical Research;Blood - brain barrier anatomy;Blood brain barrier dysfunction;Blood capillaries;Blood Tests;Blood Vessels;blood-brain barrier permeabilization;Brain;Brain Injuries;burden of illness;CADASIL;California;Capital;cell type;Central Nervous System;Central Nervous System Infections;Cerebral small vessel disease;cerebrovascular;Cerebrovascular Circulation;Cerebrum;China;Chinese;Clinical;Cognition;Cognitive;cohort;Collaborations;contrast enhanced;Contrast Media;Dementia;detection sensitivity;Development;diffusion weighted;Disease;Disease Progression;Elderly;Evaluation;Failure;Family member;Gadolinium;Genetic;Goals;Guidelines;Hemorrhage;Hospitals;Human;Image;imaging approach;imaging biomarker;Imaging Techniques;Impaired cognition;Infarction;innovation;Ischemia;Joints;Lacunar Infarctions;Lesion;Longitudinal Studies;Magnetic Resonance Imaging;Measurement;Measures;Medical;Microvascular Dysfunction;Mutation;mutation carrier;Nerve Degeneration;neuroimaging;Neuropsychology;Noise;NOTCH3 gene;Nutrient;Onset of illness;Oxygen;Pathogenesis;Pathology;Patients;Pericytes;Play;Prevention;Protocols documentation;Public Health;Publications;Resources;Role;Signal Transduction;Smooth Muscle Myocytes;Stroke;Subcortical Infarctions;Subcortical Leukoencephalopathy;targeted treatment;Technology;Testing;Therapeutic Intervention;Universities;vascular cognitive impairment and dementia;Vascular Diseases;Vascular Smooth Muscle;Visit;Water;white matter;White Matter Disease;White Matter Hyperintensity

PROJECT_TITLE: BBB Permeability Imaging in CADASIL

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OBT-W(50)R]


ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Project Narrative Cancer immunotherapy has shown great promise in combatting cancer, but interactions between cancer cells and the immune system or anti-tumor immune response within the tumor microenvironment remain to be explored to increase the potential of this approach as a major arsenal for cancer treatment.

PI_NAMEs: WANG, XIAO-FAN  (contact)

PROGRAM_OFFICER_NAME: KUO, LILLIAN S

PROJECT_TERMS: Adrenergic beta-Antagonists;anti-tumor immune response;beta-adrenergic receptor;Biological;Biological Markers;cancer cell;cancer immunotherapy;cancer therapy;Catecholamines;CD8-Positive T-Lymphocytes;Cells;Chemical Sympathectomy;chemokine;Clinical;combat;Combined Modality Therapy;Consensus;Cross Presentation;CTLA4 gene;cytokine;Dendritic cell activation;Dendritic Cells;Denervation;Disease;Disease remission;effector T cell;Exclusion;Foundations;Genes;immune checkpoint blockade;Immune system;Immunologic Factors;Immunologic Stimulation;Immunosuppression;Immunotherapy;improved;Individual;Infiltration;Inflammation;Interferon Type I;Interferons;Interleukin-12;knock-down;Malignant neoplasm of pancreas;Malignant neoplasm of prostate;Malignant Neoplasms;malignant stomach neoplasm;Mediating;melanocyte;Melanoma;Melanoma patient;Melanoma Tumor;Modeling;Molecular;mouse model;Natural Killer Cells;neoplastic cell;Nerve;Nerve Fibers;Nerve Growth Factors;nerve supply;neural;Neural Crest;Neurons;Neurotransmitters;Norepinephrine;novel;novel therapeutic intervention;Pancreas;Pathway interactions;Patients;pharmacologic;Physiological;Population;preclinical efficacy;programmed cell death protein 1;programs;Propranolol;Prospective Studies;Prostate;Receptor Signaling;recruit;Recurrence;Reporting;Resistance;response;Risk Reduction;Role;Sampling;Shapes;Signal Transduction;Solid Neoplasm;Source;Stomach;success;T-Cell Activation;T-cell inflamed;T-Lymphocyte;Testing;Therapeutic;tumor;Tumor Antigens;Tumor Burden;Tumor Escape;tumor growth;Tumor Immunity;tumor microenvironment;Tumor Tissue;tumor-immune system interactions

PROJECT_TITLE: NGF recruits nerve fibers to reprogram an immunosuppressive microenvironment in melanoma

STUDY_SECTION: TME

STUDY_SECTION_NAME: Tumor Microenvironment Study Section[TME]


PI_NAMEs: MANKOFF, DAVID A. (contact)

PROJECT_TERMS: Abbreviations;Acceleration;acronyms;Address;Advanced Malignant Neoplasm;anti-cancer research;Applications Grants;Area;Bioethics;cancer care;Cancer Center;Cancer Center Support Grant;cancer education;career;career development;Clinical;Clinical and Translational Science Awards;clinical epidemiology;Collaborations;community engagement;Community Outreach;continuing medical education;Data;Databases;Development;Discipline;Education;education research;Educational Activities;Educational Status;Ensure;environmental carcinogenesis;Evaluation;Faculty;faculty mentor;faculty research;Funding;Future;Genetic Counseling;Goals;graduate medical education;Grant;Health Policy;high school;imaging program;Improve Access;improved;Individual;innovation;Lead;Leadership;Malignant Neoplasms;Measures;Medical;medical schools;member;Mentored Clinical Scientist Development Program;Mentors;Mentorship;Minority;Mission;NCI Center for Cancer Research;operation;Outcome;Pediatric Hospitals;Peer Review;Pennsylvania;Philadelphia;Physics;population based;post-doctoral training;Preparation;Professional Education;programs;Radiation;Radiobiology;Research;Research Methodology;Research Personnel;Research Training;Resource Sharing;Role;Schedule;Schools;Science;Scientific Inquiry;Scientist;Students;success;Testing;tobacco carcinogenesis;tool;Training;Training Activity;Training and Education;training opportunity;Training Programs;translational medicine;Translational Research;translational therapeutics;undergraduate medical education;undergraduate student;Underrepresented Minority;Universities;Woman;Youth

PROJECT_TITLE: Cancer Research Training and Education Coordination