ED_INST_TYPE: OTHER SPECIALIZED SCHOOLS

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Assistive Technology;Bioengineering;Biotechnology;Brain Disorders;Dementia;Nanotechnology;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: CAMBRIDGE

ORG_DEPT: MISCELLANEOUS

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

PHR: Bioelectronic implants provide powerful tools for healthcare as well as basic research but their implantation require invasive surgery which is associated with pain and adverse physical as well as psychological effects. We are developing a technology in which ultra-miniaturized bioelectronic devices can get implanted in target regions and provide localized sensing and treatment without the need for surgery. This administrative supplement will extend our technology to Alzheimer’s disease which can lead to a novel therapeutics for preventing the spread and even development of this disease.

PI_NAMEs: SARKAR, DEBLINA  (contact)

PROGRAM_OFFICER_NAME: AGRAWAL, NITIN

PROJECT_TERMS: abeta accumulation;Administrative Supplement;Alzheimer's Disease;Alzheimer's disease therapeutic;Alzheimer's disease therapy;Area;Basic Science;bioelectronics;Biological;Biological Transport;biomaterial compatibility;Biotechnology;Blood;Body part;body sense;Brain;Brain Diseases;Brain region;calcium indicator;Cardiovascular system;Cells;Circulation;Computers;Confidential Information;Data Analyses;Decision Making;Development;Devices;Diagnosis;Dimensions;Disease;Dryness;Early Intervention;electric field;electronic stimulator;Electronics;energy efficiency;Environment;Evaluation;Feedback;FOS gene;Foundations;Funding;Future;Government;Harvest;Healthcare;Hybrids;Image;Impaired cognition;Implant;implantable device;implantation;improved;In Vitro;in vivo evaluation;Inflammation;Intervention;Metabolism;miniaturize;Mus;Names;nano;nanoelectronics;nanosized;neural implant;neural stimulation;Neurodegenerative Disorders;neuroinflammation;neuron loss;Neurons;neuroregulation;novel;novel therapeutics;Operative Surgical Procedures;Optics;Outcome;Pacemakers;Pain;parent project;Parents;Pathologic;Patients;Performance;Peripheral Nervous System;Persons;Physics;prevent;Procedures;Process;Property;psychologic;Regenerative Medicine;Regional Disease;Research;Resolution;response;Silicon;simulation;Site;spatiotemporal;Stream;Surface;synthetic biology;System;tau Proteins;Techniques;Technology;Testing;Therapeutic;Thinness;Time;Tissue Engineering;Tissues;tool;Travel;tumor;voltage;wireless;Wireless Technology;Work

PROJECT_TITLE: Circulatronics: A New Paradigm for Biomedical Implants


ADMINISTERING_IC: AI

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Immunization;Immunotherapy;Infectious Diseases;Rare Diseases;Vaccine Related

ORG_CITY: ROCHESTER

ORG_COUNTRY: UNITED STATES

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF ROCHESTER

ORG_STATE: NY

PHR: PROJECT NARRATIVE This research aims to establish robust mouse models for cryptosporidiosis and investigate the complexities of IFN-γ responses, ultimately contributing to innovative strategies for combatting this pressing global health threat.

PI_NAMEs: YAROVINSKY, FELIX  (contact)

PROGRAM_OFFICER_NAME: PESCE, JOHN T

PROJECT_TERMS: Abdominal Cramps;Acute;Address;Affect;Animal Model;Animals;Applications Grants;Area;Body Weight decreased;cell type;Cells;Child;combat;Complex;Consumption;Cryptosporidiosis;Cryptosporidium;Cryptosporidium parvum;Dangerousness;Data;Developing Countries;Development;Diarrhea;Disease;Disease Outbreaks;effective therapy;Epithelial Cells;Epithelium;experience;Family;Fever;Food Contamination;gastrointestinal;global health;Health;Host Defense;Host resistance;Human;Immune;Immune response;Immune system;Immunity;Immunocompromised Host;immunopathology;in vivo;Individual;Infection;innate immune mechanisms;innovation;insight;Interferon Gamma Receptor Complex;Interferon Type II;Interferons;Interleukin-12;intestinal epithelium;Intestines;Knowledge;Life;Malaria;Mediating;Molecular;mouse model;Mucosal Immunity;mucosal site;Mucous Membrane;Mus;Natural Immunity;Nausea;novel therapeutics;Outcome;Parasites;pathogen;Pathogenesis;Pathologic;Pathology;Pathway interactions;Play;prevent;Production;profilin;Proteins;Regulation;Reporting;Research;Research Proposals;response;Role;Severities;Signaling Molecule;Structure;Symptoms;Toll-like receptor 11;tool;Toxoplasma gondii;United States;vaccine candidate;vaccine development;Vaccine Therapy;Vaccines;Vomiting;waterborne illness

PROJECT_TITLE: Understanding Innate Immune Recognition and IFN-g-Mediated Immunity in Cryptosporidiosis

STUDY_SECTION: IHD

STUDY_SECTION_NAME: Immunity and Host Defense Study Section[IHD]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics

ORG_CITY: HADLEY

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF MASSACHUSETTS AMHERST

ORG_STATE: MA

PHR: Project Narrative This is relevant to public health because abnormal shape of the cell nucleus is a hallmark of human disease. A weaker nucleus leads to abnormal shape and eventual rupture resulting in disruptions of normal cell functions. We will determine how the changes to genome compaction, reading, and division cause abnormal shape of the cell nucleus, a dysfunction that contributes to human disease.

PI_NAMEs: STEPHENS, ANDREW DANIEL (contact)

PROGRAM_OFFICER_NAME: VATAKIS, DIMITRIOS NIKOLAOS

PROJECT_TERMS: Actins;Address;Bulla;Cell Nucleus;Cell Physiology;Cell Shape;Chromatin;Data;diagnostic biomarker;Disease;Disease Progression;Functional disorder;Genetic Transcription;Genome;Genomics;Goals;Heterochromatin;histone modification;human disease;innovation;Interphase;Knowledge;Lamins;live cell microscopy;Measures;Mechanics;Micromanipulation;Mitotic;Morphology;Motion;Normal Cell;Nuclear;Pathway interactions;physical property;programs;Public Health;Qualifying;Reading;Research;Role;Rupture;segregation;Shapes;Techniques;therapeutic target;Work

PROJECT_TITLE: Role of chromatin mechanics in nuclear shape and integrity

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


ED_INST_TYPE: SCHOOLS OF MEDICINE

ORG_CITY: NEW YORK

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE Metabolites inside cells can directly regulate chromatin, the mixture of DNA and proteins in the cell nucleus. Polyamines are abundant metabolites essential for multiple biological processes, but their mechanisms of action remain poorly understood. In this proposal, we explore the hypothesis that polyamines concentrate in specific areas of the nucleus, where they bind and regulate chromatin and ultimately control cell identity.

PI_NAMEs: SCHVARTZMAN, JUAN MANUEL  (contact)

PROGRAM_OFFICER_NAME: CHOW, CHI-WING

PROJECT_TERMS: Affect;Anabolism;Area;Binding;Biological Process;Biology;Cell Differentiation process;cell growth;Cell Nucleus;Cell Reprogramming;Cells;Charge;Chemicals;Chromatin;chromatin modification;cofactor;Deposition;DNA;DNA biosynthesis;Enzyme Inhibitor Drugs;Enzymes;Epigenetic Process;Eukaryotic Cell;Excision;extracellular;Generations;Genetic Transcription;Growth;Histones;Homeostasis;In Vitro;in vivo;infancy;macromolecule;Metabolic;metabolic abnormality assessment;Metabolism;Methods;National Institute of General Medical Sciences;Nuclear;Nuclear Structure;Polyamines;progenitor;programs;Proliferating;Proteins;Reaction;Research;RNA;Role;Stress;tool;transcription factor;Work

PROJECT_TITLE: Effects of polyamines on chromatin function

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MGG-D (55)]


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Biotechnology;Kidney Disease;Orphan Drug;Pediatric;Rare Diseases

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE S1P lyase insufficiency syndrome (SPLIS) is a rare inborn error of metabolism associated with kidney failure and a high rate of mortality. SPLIS is caused by inherited defects in a critical enzyme needed to break down sphingolipids. In this study, we will test whether enzyme replacement therapy using a bacterial form of S1P lyase given intravenously can prevent kidney disease and prolong survival in two different mouse models of SPLIS.

PI_NAMEs: SABA, JULIE D (contact)

PROGRAM_OFFICER_NAME: PITTENGER, STEVEN THEODORE

PROJECT_TERMS: Adrenal gland hypofunction;Adult;Affect;Biochemistry;Biological Markers;Biology;Blood;Catabolism;Cause of Death;Child;Clinical Trials;Coenzymes;cohort;comparison intervention;Complex;cost;curative treatments;Death Rate;Defect;Dependovirus;Development;Diagnostic;Diet;Disease;Dose;Drug Kinetics;Edema;efficacy study;enzyme replacement therapy;Enzymes;Exhibits;Failure;Failure to Thrive;Familiarity;Functional disorder;Future;gene therapy;Genes;glomerulosclerosis;Goals;Growth;Hypothyroidism;Immune response;immunodeficiency;Impairment;Inborn Errors of Metabolism;infancy;Inherited;Intervention;Intraperitoneal Injections;Intravenous;Intravenous infusion procedures;Investigation;Investments;Kidney;Kidney Diseases;Kidney Failure;kidney preservation;Kidney Transplantation;Knock-in Mouse;Knock-out;Knockout Mice;Life;Lipids;Lyase;manufacture;Measures;Mediating;Medical;Metabolic Diseases;Metabolism;Modeling;Monitor;Morbidity - disease rate;mouse model;Mus;Mutation;Natural History;Nephrosis;Nephrotic Syndrome;neurodevelopment;Neurologic;novel;Organ;Patients;Pharmacodynamics;pharmacokinetics and pharmacodynamics;Plasma;Positioning Attribute;pre-clinical;Pre-Clinical Model;pre-clinical therapy;preclinical efficacy;prenatal;prevent;programs;prospective;Protein Biosynthesis;Proteinuria;pup;Rare Diseases;Renal function;Resources;Saccharomycetales;Skin;Sphingolipids;sphingosine 1-phosphate;sphingosine phosphate lyase insufficiency syndrome;sphingosine-1-phosphate lyase;Supplementation;Syndrome;System;targeted treatment;Tay-Sachs Disease;Testing;Therapeutic;Therapeutic Agents;therapeutic evaluation;Time;tool;Toxic effect;treatment strategy;Variant;Vitamin B6;Weaning;Weight;Weight Gain;Wild Type Mouse;working group

PROJECT_TITLE: Proof-of-concept for the use of enzyme replacement therapy as a lifesaving treatment for sphingosine phosphate lyase insufficiency syndrome

STUDY_SECTION_NAME: Special Emphasis Panel[ZTR1 RD-1 (01)]


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF EDUCATION

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Parkinson's Disease

ORG_CITY: LOGAN

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UTAH STATE UNIVERSITY

ORG_STATE: UT

PHR: PROJECT NARRATIVE Neurodegenerative disorders such as Parkinson’s Disease, Huntington’s Disease, and Alzheimer’s Disease are characterized by drastic impairments in planning and decision making, some of which stem from deficits in estimating durations. By investigating timekeeping we aim to understand the circuits involved in planning and decision making. The project will enhance our understanding of the role of these circuits in cognitive control, and will help assessing potential treatment strategies in animal models with subsequent impact on clinical treatments.

PI_NAMEs: BUHUSI, CATALIN V. (contact)

PROGRAM_OFFICER_NAME: SIEBER, BETH-ANNE

PROJECT_TERMS: Address;Administrative Supplement;Agonist;alertness;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease patient;Animal Model;Arousal;Association Learning;Behavioral;Biochemical;C57BL/6 Mouse;Clinical Treatment;Cognition;Cognitive;cognitive control;Cognitive deficits;cognitive function;Corpus striatum structure;Data;Decision Making;Diurnal Rhythm;Dopamine;Episodic memory;executive function;frontal lobe;Genetic;Grant;Huntington Disease;hypocretin;Hypothalamic structure;Impairment;improved;innovation;Investigation;Lateral;Memory;memory recognition;Methods;migration;Modeling;motivated behavior;Motor;motor control;mouse model;Mus;neural circuit;Neurodegenerative Disorders;neuronal circuitry;Neurons;novel;novel therapeutic intervention;novel therapeutics;object recognition;parent grant;Parkinson Disease;Parkinsonian Disorders;Patients;Performance;Pharmaceutical Preparations;pharmacologic;Process;Production;Protocols documentation;Reaction Time;Reproduction;response;Role;Sleep;Sleep Wake Cycle;spatial memory;stem;sustained attention;Time;treatment strategy;United States National Institutes of Health;vigilance;Wakefulness

PROJECT_TITLE: Arousal and Timekeeping in a Mouse Model of Parkisonism (Supplement)


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Congenital Structural Anomalies;Dissemination and Implementation Research;Pediatric;Prevention;Urologic Diseases

ORG_CITY: CHAPEL HILL

ORG_DEPT: UROLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE About 1 in 250 newborn boys has a birth defect known as hypospadias in which the opening of the penis is on the underside instead of at the tip. Parents of boys with this condition frequently experience decisional conflict when deciding upon treatment and regret their decision after treatment. The goals of this project are to a) test whether a tool, the Hypospadias Hub, can reduce the amount of parental conflict and regret and improve parental knowledge by increasing parental involvement in complex decisions regarding their child’s treatment and to b) improve the quality of decisions in pediatric urology and overall child health and quality of life.

PI_NAMEs: SCHILLING, SAMANTHA S (contact)

PROGRAM_OFFICER_NAME: GIPSON, DEBBIE SUE

PROJECT_TERMS: 2 arm randomized control trial;Adoption;Adult;Affect;Aftercare;Appearance;arm;boys;Caring;Centers for Disease Control and Prevention (U.S.);Child;Child Health;Childhood;Clinic;Clinical;Complex;Conflict (Psychology);Congenital Abnormality;Consolidated Framework for Implementation Research;Consultations;Control Groups;Cosmetics;cost;Decision Aid;Decision Making;design;Effectiveness;effectiveness/implementation study;Epidemiology;ethnic diversity;Evaluation;evidence base;experience;Fertility;Fistula;Fostering;future implementation;Goals;Health;Hypospadias;implementation evaluation;implementation strategy;improved;insight;Intervention;intervention delivery;Interview;Knowledge;Left;literacy;long-term sequelae;Measures;Newborn Infant;Nurses;Online Systems;Operative Surgical Procedures;Outcome;parental influence;parental involvement;Parents;Patients;penis;Pilot Projects;pilot test;Postoperative Complications;Postoperative Period;preference;primary outcome;Process;Provider;Quality of life;Questionnaires;racial diversity;Randomized;Randomized, Controlled Trials;Recommendation;Reconstructive Surgical Procedures;Regrets;Reporting;Sampling;satisfaction;secondary outcome;Severity of illness;Sex Functioning;shared decision making;Signal Transduction;Site;Testing;tool;tool development;Transcript;Uncertainty;Urethra;Urethral Meatus Stenosis;Urination;urologic;Urology;usability;user centered design

PROJECT_TITLE: A type I hybrid effectiveness-implementation study of a parent-centered tool to promote shared decision-making in hypospadias care

STUDY_SECTION: HSQE

STUDY_SECTION_NAME: Health Services: Quality and Effectiveness Study Section[HSQE]


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Networking and Information Technology R&D (NITRD);Pediatric;Pediatric Cancer;Rare Diseases;Telehealth

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

PHR: PROJECT NARRATIVE Communication that includes the child’s perspective and can be understood and acted upon by parents and clinicians is key to managing symptoms associated with childhood cancer and its treatment. The proposed project will develop and test an intervention to improve symptom communication during early childhood cancer treatment using Color Me Healthy, a game-based symptom assessment app for children. We will develop and test a clinician-facing version of the app that allows children’s data to be included in the electronic health record to improve communication about children’s symptoms during clinic visits.

PI_NAMEs: LINDER, LAURI A (contact)

PROGRAM_OFFICER_NAME: D'ANGELO, HEATHER

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;Adoption;Advisory Committees;Area;assessment application;associated symptom;Attention;Behavior Therapy;cancer therapy;caregiving;Caring;Characteristics;Child;Child Health;Childhood Cancer Treatment;Clinic Visits;Clinical;clinical care;Clinical Data;clinical research site;Color;common symptom;Communication;Complement;Consensus;Data;data exchange;data interoperability;Data Reporting;Data Security;data standards;design;Development;Diagnosis;digital health;Disease;Documentation;early childhood;efficacy evaluation;Electronic Health Record;electronic health record system;Emerging Technologies;evidence base;Evidence based intervention;Family;Fast Healthcare Interoperability Resources;Feedback;Feeling;Foundations;Goals;Health;health communication;health data;health information technology;Health Priorities;health record;improved;Individual;innovation;insight;Institution;interoperability;Intervention;Interview;Malignant Childhood Neoplasm;Malignant Neoplasms;Measures;Medical;Methods;mhealth interventions;Mobile Health Application;National Cancer Institute;Online Systems;Outcome;Parents;patient oriented;Patient Self-Report;Patients;Pediatric Oncology Group;Phase;Population;Process;Public Health Informatics;Quality of life;Recommendation;reduce symptoms;Reporting;School-Age Population;Science;Self Efficacy;Self Management;Severities;Site;Structure;symposium;symptom management;symptom self management;symptomatic improvement;Symptoms;System;Technology;Testing;theories;therapy development;Time;tool;treatment duration;trend;usability;user centered design;verbal;Work

PROJECT_TITLE: mHealth Intervention to Support Symptom Communication for Children with Cancer

STUDY_SECTION: CIDH

STUDY_SECTION_NAME: Clinical Informatics and Digital Health Study Section[CIDH]


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_CITY: HANOVER

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: Project Narrative Common genetic variation contributes substantially to human diseases. A deep understanding of the functional impact of common genetic variants is required to identify disease-causal variants and decipher disease mechanisms. We propose to bridge the gap from genetic variants to diseases by integrative analysis of functional genomics and genome-wide association studies (GWAS) data.

PI_NAMEs: ZHAO, SIMING  (contact)

PROGRAM_OFFICER_NAME: MASKERI, BAISHALI

PROJECT_TERMS: Address;Affect;Area;causal variant;Cells;Chromatin;Communities;Data;Data Set;Disease;epigenomics;Etiology;functional genomics;Gene Expression;Generations;Genes;Genetic;Genetic Diseases;Genetic study;genetic variant;Genetic Variation;genome wide association study;genomic data;Genomic Segment;Goals;human disease;Human Genetics;Individual;insight;Maps;Methods;novel;novel strategies;open source tool;programs;Property;Quantitative Trait Loci;Research;Research Personnel;Resolution;response;Role;Statistical Data Interpretation;Statistical Methods;Statistical Models;Tissues;tool;transcriptomics;Untranslated RNA;Variant;Work

PROJECT_TITLE: Statistical methods and analyses to study genetic variants and their roles in diseases leveraging functional genomics data.

STUDY_SECTION: MRAF

STUDY_SECTION_NAME: Maximizing Investigators' Research Award - F Study Section[MRAF]


ORG_CITY: HOUSTON

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: PROJECT NARRATIVE Many RNA species within a cell are spatially localized and locally translated into proteins, and previous studies in embryos, neurons, and highly-dynamic tissues have demonstrated the vital importance of RNA subcellular location in development and cellular function. However, it has been challenging to study localization transcriptome-wide, which has hampered understanding of the extent and role of such processes in normal and diseased tissues. The proposed work will apply a newly-developed tool for the RNA community to investigate spatial transcriptomics and use it to provide new insights into RNA biology by determining the contribution and regulation of cytoskeletal motor proteins and associated factors to actively transport specific RNAs to their destinations.

PI_NAMEs: FAZAL, FURQAN  (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TERMS: Active Biological Transport;Atlases;Biochemical;Biological Models;Biology;Cell Physiology;Cells;Cellular biology;Chemicals;cofactor;Communities;Cytoplasm;Cytoskeleton;Destinations;Development;Disease;Dynein ATPase;Elements;Embryo;Enzymes;experimental study;Genes;Genetic;Human;In Vitro;Individual;insight;Kinesin;Label;Link;Location;Maintenance;Malignant Neoplasms;Messenger RNA;Microfilaments;Microtubules;Mitochondria;Molecular Motors;Motor;Mutation;Myosin ATPase;Nerve Degeneration;Neurons;Organelles;Organism;Outer Mitochondrial Membrane;Pattern;Peroxidases;Postdoctoral Fellow;Process;programs;Protein Isoforms;Proteins;reconstitution;Regulation;Research;Research Personnel;RNA;RNA Splicing;RNA Transport;RNA-Binding Proteins;Role;Specificity;System;Technology;temporal measurement;Time;Tissues;tool;Transcript;transcriptome;transcriptome sequencing;transcriptomics;Translating;Translations;Walking;Work

PROJECT_TITLE: Role of Cytoskeletal Motor Proteins in Subcellular RNA Localization

STUDY_SECTION: MRAD

STUDY_SECTION_NAME: Maximizing Investigators' Research Award - D Study Section[MRAD]


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Wound Healing and Care

ORG_CITY: Chicago

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative Healthy individuals have a tremendous ability to heal after injury, which involves complex and coordinated actions of various cell types acting across sequential healing phases in space and time. This project aims to understand how oral wounds, which heal better and faster than skin wounds, optimize the healing process, and how chronic diseases such as diabetes and cancer corrupt the healing process. We will focus on studying these differential healing outcomes using an innovative analytical approach that takes into account cellular dynamics across the healing continuum in both space and time, with the goal of identifying important gene signatures in cells that may lead to new targeted therapies for chronic wounds and tumors.

PI_NAMEs: WIETECHA, MATEUSZ S (contact)

PROGRAM_OFFICER_NAME: CHAO, CHIEN-CHUNG

PROJECT_TERMS: Animal Model;carcinogenesis;Cell Communication;Cell model;cell type;Cells;Chronic Disease;chronic wound;Complex;Data Set;Diabetes Mellitus;diabetic;diabetic ulcer;diabetic wound healing;Diagnostic;disease model;Disease Progression;Gene Expression Profile;gene regulatory network;genetic signature;Goals;healing;Homeostasis;Human Pathology;Individual;Inflammatory;injured;Injury;innovation;malignant mouth neoplasm;Malignant Neoplasms;Methods;Modeling;mouse model;Network-based;new therapeutic target;novel;Oral;oral carcinogenesis;Oral cavity;Outcome;Pathologic;Pathway interactions;Phase;Population Dynamics;Process;prognostic;regenerative;reparative healing;Research Proposals;Resolution;Skin;Skin Carcinogenesis;skin healing;Skin injury;skin wound;spatiotemporal;Surgical wound;Technology;Therapeutic;Time;Tissues;traumatic wound;tumor;tumor progression;wound;wound healing;Wound models

PROJECT_TITLE: Spatio-temporal cellular dynamics regulating differential healing outcomes


ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE Metabolite damage and repair is a widespread and universal reality of life and disruption of repair systems causes metabolic diseases that can be fatal, yet metabolite damage remains largely unrecognized and understudied. I have identified and laid the groundwork for full characterization of a universal metabolite damage repair enzyme that is critical for operation of the TCA cycle. By characterizing this enzyme in model organisms with biochemical, genetic, and metabolomics/ fluxomics techniques, I will redefine one of the most universal core metabolic pathways in biology, providing mechanistic insights into aerobic respiration that are likely to impact human health and disease.

PI_NAMEs: NIEHAUS, THOMAS D (contact)

PROGRAM_OFFICER_NAME: BARSKI, OLEG

PROJECT_TERMS: amino acid metabolism;Attenuated;Biochemical;Biochemical Pathway;Biology;Carbon;catalyst;Cell Respiration;Cells;Chemicals;Citric Acid Cycle;cofactor;Disease;empowerment;enol;Enzymes;flexibility;gene repair;Genetic;Health;Human;inhibitor;insight;Life;Malates;Metabolic;Metabolic Diseases;Metabolic Pathway;Metabolism;metabolomics;mitochondrial metabolism;model organism;Nature;operation;organic acid;Oxaloacetates;Pathway interactions;Physiological;Physiology;Proteins;Reaction;repair enzyme;repaired;Side;skills;Source;Succinate Dehydrogenase;synthetic biology;System;Techniques;Toxic effect;Training;Vitamins;Work

PROJECT_TITLE: Unraveling the physiological and metabolic impacts of a universal metabolite repair enzyme that removes a strong inhibitor of the TCA cycle

STUDY_SECTION: MRAE

STUDY_SECTION_NAME: Maximizing Investigators' Research Award - E Study Section[MRAE]


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Basic Behavioral and Social Science;Behavioral and Social Science;Childhood Injury;Disability Research;Lung;Neurosciences;Orphan Drug;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Rare Diseases;Unintentional Childhood Injury

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Project Narrative Low oxygen delivery (hypoxia) to the developing brain is the leading cause of life-long neurological disabilities in preterm babies and is linked to learning disabilities and memory problems. This proposal focuses on the impact of a single exposure to mild hypoxia in the newborn period on long-term disturbances in the maturation of neurons responsible for mechanisms of learning and memory in adults. We will employ novel approaches to define cellular and molecular mechanisms that disrupt the establishment of learning and memory circuitry during a critical window in brain development and will test potential new therapies to improve learning and memory disturbances caused by Hx in the newborn period.

PI_NAMEs: BACK, STEPHEN ARTHUR (contact);MAYLIE, JAMES G

PROGRAM_OFFICER_NAME: DOPERALSKI, ADELE ELIZABETH

PROJECT_TERMS: Abbreviations;Action Potentials;Acute;acute hypoxemic respiratory failure;Acute respiratory failure;Adolescent;Adult;Agonist;AMPA Receptors;Animal Model;Behavioral;Brain;Brain Hypoxia-Ischemia;Brain Injuries;Calcium-Activated Potassium Channel;Cell Death;Cell Nucleus;cell type;Cerebral Palsy;Cerebrum;Chronic;Clinical Management;clinically relevant;cognitive disability;Complication;conditioned fear;Critical Illness;Data;density;Development;Developmental Disabilities;diagnostic strategy;Elements;Epigenetic Process;Event;Excitatory Postsynaptic Potentials;Exposure to;Feedback;fetal;fetus hypoxia;Gene Expression;Genetic Transcription;Glutamate Receptor;Glutamates;gray matter;Growth;Hippocampus;Hypoxia;hypoxia neonatorum;Impairment;improved;In Vitro;in vivo;Inflammation;innovation;Ischemia;Learning;Learning Disabilities;Life;light microscopy;Link;Long-Term Potentiation;Lung;Magnetic Resonance Imaging;mature animal;Mediating;Memory;Memory impairment;Molecular;mouse model;Mus;N-Methyl-D-Aspartate Receptors;Neonatal;neonatal care;neonatal resuscitation;neonate;Nerve Degeneration;neurobehavioral test;Neuroglia;Neurological disability;neuron loss;Neurons;neurotransmission;Newborn Infant;novel;novel diagnostics;novel strategies;novel therapeutics;Nuclear;Oligodendroglia;Outcome;Oxygen;Pathway interactions;postnatal;Potassium Channel;Predisposition;premature;Premature Birth;Premature Infant;preterm newborn;prevent;Property;Protein-Serine-Threonine Kinases;response;Risk;Role;School-Age Population;Severities;Short-Term Memory;single nucleus RNA-sequencing;Survivors;Synapses;Synaptic plasticity;Synaptic Transmission;Testing;therapy development;transcriptome sequencing;transcriptomics;ultra high resolution;Uterus;verbal;Vertebral column;white matter injury;young adult

PROJECT_TITLE: Mechanisms of hypoxia-mediated memory impairment in an animal model of acute respiratory failure in preterm survivors

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


ORG_CITY: COLLEGE STATION

ORG_NAME: TEXAS A&M UNIVERSITY

PHR: Project Narrative  The proposed research aims to understand the diversity of strategies used by the natural predators of bacteria, the bacteriophages, to kill their host targets. By studying how phage kill bacteria in depth, we can formulate new strategies to eliminate problematic pathogens that cause human disease. Thus, this proposal supports the NIGMS mission to fund research laying the foundation for advances in human disease treatment and prevention.

PI_NAMEs: RAMSEY, JOLENE  (contact)

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TERMS: alternative treatment;anti-microbial peptide;Bacteria;Bacterial Antibiotic Resistance;Bacterial Infections;Bacteriophage mu;Bacteriophage T4;Bacteriophages;Behavior;Biochemical;Bioinformatics;Biological Assay;Biological Models;cell envelope;Cells;Characteristics;Cytolysis;Educational process of instructing;endolysin;Escherichia coli;Event;fitness;Foundations;Funding;Genetic;Goals;Gram-Negative Bacteria;gut microbiota;Human;human disease;Individual;Life;Medical;Membrane;microbial;Microbial Biofilms;Microscopy;Mission;Molecular;National Institute of General Medical Sciences;novel;Nutrient;pathogen;Pathway interactions;Peptidoglycan;Planets;Population;Population Dynamics;Prevention;Process;Proteins;Regulation;Research;Sequence Analysis;System;Tail;Time;Toxin;Virion

PROJECT_TITLE: Bacteriophage strategies to lyse bacterial cells


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_DEPT: GENETICS

PHR: Narrative Microglia and the complement pathway play critical roles in Alzheimer’s disease. The proposal seeks to understand the role of complement and associated metabolic pathways and identify novel cell-surface receptors in microglia regulation in vitro and in AD mouse models. It will provide novel pathophysiological insights and uncover potential therapeutic targets.

PI_NAMEs: ZHENG, HUI  (contact)

PROGRAM_OFFICER_NAME: OPANASHUK, LISA A

PROJECT_TERMS: Acceleration;age related;Alleles;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease patient;Amyloid;Amyloid beta-Protein;amyloid pathology;Behavioral;Binding;Biochemical;Brain;candidate identification;CD36 gene;Cell surface;Cell Surface Proteins;Cell Surface Receptors;cell type;Cells;Chronic;Cognition;Complement;Complement 3a;complement C3 precursor;complement pathway;conditional knockout;Dependence;Development;extracellular;Flow Cytometry;functional decline;Functional disorder;genome wide association study;Goals;HIF1A gene;Hippocampus;Homeostasis;Horseradish Peroxidase;Hypoxia Inducible Factor;Image;Immune;Immunomodulators;Immunotherapeutic agent;Impairment;In Situ;In Vitro;in vivo;in vivo evaluation;Inflammatory;inhibitor;Injections;insight;Knock-in;Knock-in Mouse;Label;Ligands;Link;lipidomics;Lipids;loss of function;Mass Spectrum Analysis;Measures;Mediating;Medicine;Membrane;Metabolic;metabolic fitness;Metabolic Pathway;Metabolism;Methods;Microglia;Molecular Profiling;mouse model;Mus;mutant;Neurofibrillary Tangles;neuroinflammation;Neurons;neuropathology;Neuropeptides;novel;Nuclear RNA;Oxygen;Pathogenesis;Pathology;Pathway interactions;Phagocytes;Phagocytosis;Phenotype;Play;Process;Property;Proteome;Proteomics;receptor;receptor expression;Receptor Signaling;Recycling;Regulation;Reporter;response;Role;Sampling;Senile Plaques;Signal Transduction;Tamoxifen;Testing;Therapeutic;therapeutic target;trafficking;transcriptome sequencing;transcriptomics;TREM2 gene;uptake;Work

PROJECT_TITLE: The Role of the Complement Pathway in Alzheimer's Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 AN-Z (55)]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Infectious Diseases;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Urologic Diseases;Women's Health Research

ORG_CITY: RESEARCH TRIANGLE PARK

ORG_NAME: RESEARCH TRIANGLE INSTITUTE

PHR: Project Narrative More than 20 million newborns worldwide each year are considered to have low birth weight (weighing less than 2,500 grams or approximately 5.5 pounds) and experience a higher rate of complications than those whose birth weight is considered normal. Prior studies have suggested that screening for asymptomatic bacteria in the mother’s urine during pregnancy and treating with antibiotics (nitrofurantoin) may reduce the incidence of low birth weight. This study explores the impact of treating asymptomatic bacteria in the urine of pregnant individuals in low- and middle-income countries, where the burden of low birth weight is the highest and the potential impact of intervention is the greatest.

PI_NAMEs: CHISHOLM, CHRISTIAN A;MCCLURE, ELIZABETH M (contact)

PROGRAM_OFFICER_NAME: CHAKHTOURA, NAHIDA ABDO

PROJECT_TERMS: Address;Antibiotic Therapy;Antibiotics;Applications Grants;arm;Bacteria;Bacteriuria;Bangladesh;Birth Weight;Child Health;Clinical Treatment;Clinical Trials;Collaborations;Conduct Clinical Trials;Data;Data Coordinating Center;development policy;diarrheal disease;Discipline of obstetrics;Double-Blind Method;double-blind placebo controlled trial;Enrollment;Epidemiologist;experience;Foundations;Health Policy;Incidence;Individual;Infectious Diseases Research;Infrastructure;innovation;International;international center;Intervention;Investigation;kidney infection;Lead;Leadership;Literature;low and middle-income countries;Low Birth Weight Infant;Maternal and Child Health;maternal morbidity;Maternal-fetal medicine;member;Morbidity - disease rate;Mothers;National Institute of Child Health and Human Development;neonatal health;neonatal morbidity;Neonatal Mortality;Newborn Infant;Nitrofurantoin;Outcome Measure;Participant;Patient Recruitments;Perinatal;Placebo Control;Placebos;Population;Postpartum Period;Practice Guidelines;Pre-Eclampsia;Pregnancy;pregnant;Pregnant Women;Premature Birth;primary outcome;Principal Investigator;Professional Organizations;prospective;Ramp;Randomized;Randomized, Controlled Trials;Registries;Research;Research Personnel;Risk;screening;secondary outcome;Site;Testing;Training;treatment effect;United States Preventative Services Task Force;Universities;Urine;Virginia;Woman;Work;World Health Organization

PROJECT_TITLE: A Prospective Randomized Controlled Trial to Evaluate the Impact of Treatment of Asymptomatic Bacteriuria on Low Birth Weight

STUDY_SECTION_NAME: Special Emphasis Panel[ZHD1 DSR-C (55)]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Disorders;Breast Cancer;Cancer;Nanotechnology;Neurosciences;Women's Health Research

ORG_DEPT: PHARMACOLOGY

PHR: PROJECT NARRATIVE Brain metastasis is a prevalent and deadly condition for patients with metastatic breast cancer currently with no effective pharmacological interventions or cures. Our recent work suggests that Yes Associated Protein (YAP) promotes breast cancer cells’ metastatic growth in the brain through its interaction with TEAD family transcription factors; the use of YAP inhibitors to disrupt YAP-TEAD association can be a promising therapeutic approach for brain metastasis, but its practical untility is hindered by the limited accumulation of these drugs to multi-focal metastatic lesions because of multiple biological barriers such as the blood-brain and blood-tumor-barriers. Here, we propose to engineer drug nanoparticle-coated macrophages to target “hard-to-reach” brain metastatic lesions for efficiently disrupting YAP-TEAD interactions in metastatic cells, which can potentially revolutionize how brain metastasis is targeted and pharmacologically treated.

PI_NAMEs: ER, EKREM EMRAH ;ZHAO, ZONGMIN  (contact)

PROGRAM_OFFICER_NAME: WU, YICONG

PROJECT_TERMS: Address;Apoptosis;Artificial nanoparticles;Biocompatible Materials;Biodistribution;Biological;Blood;blood-brain tumor barrier;Brain;Breast Cancer Cell;breast cancer metastasis;Breast Cancer Patient;cancer cell;Cause of Death;Cell Adhesion;Cell Proliferation;Cell Therapy;Cells;Chemotherapy and/or radiation;Clinical;Clinical Research;clinical translation;design;Drug Delivery Systems;Drug Targeting;Drug usage;effective therapy;efficacy evaluation;Engineering;Evolution;Family;Genes;Goals;Growth;Human;in vivo;Inflammation;inhibitor;innovation;Intervention;Lead;Lesion;Macrophage;Malignant Breast Neoplasm;mechanotransduction;Metastatic breast cancer;Metastatic malignant neoplasm to brain;migration;Modeling;Mus;nano;nanoparticle;nanoparticle delivery;nanoparticle drug;Neoplasm Metastasis;novel;novel strategies;novel therapeutic intervention;Nuclear;Organ;Pathway interactions;Patients;Performance;Pharmaceutical Preparations;pharmacologic;Phenotype;Preclinical Testing;Primary Neoplasm;Proliferating;Proteins;radioresistant;Resistance;Resistance development;Signal Transduction;Surface;targeted delivery;targeted treatment;Technology;Therapeutic;therapeutically effective;Tissues;Transcription Coactivator;transcription factor;tumor;tumor growth;Work

PROJECT_TITLE: Nanoparticle-coated macrophages for targeted disruption of YAP/TEAD interactions in breast cancer brain metastasis

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-A (M1)]


ORG_CITY: BETHESDA

ORG_NAME: U.S. NATIONAL INST DIABETES/DIGST/KIDNEY

ORG_STATE: MD

PHR: PROJECT NARRATIVE The family of anti-obesity drugs called glucagon-like-peptide 1 receptor agonists (GLP1RAs) have contributed revolutionary strides in combatting obesity—a growing epidemic that is estimated to affect approximately 40% of adults and 20% of adolescents and children in the US. Despite an emerging consensus that these peripherally administered GLP1RAs exert their effects on appetite suppression through the central nervous system, knowledge of the neural pathways and intracellular signaling mechanisms by which they act and how these may change over long-term usage remains limited. Given the continued prevalence and chronic nature of GLP1RA medications, my work to elucidate the intracellular and circuit-level processes of GLP1RAs in a longitudinal manner will provide foundational insights toward the improvement of pharmacological therapeutics to treat obesity.

PI_NAMEs: GAO, CLAIRE  (contact)

PROGRAM_OFFICER_NAME: NELSON, SHAKIRA M

PROJECT_TERMS: Ablation;Acute;Adolescent;Adult;Affect;Agonist;Anti-Obesity Agents;Appetite Regulation;Area;Axon;Biosensor;Blood - brain barrier anatomy;Body Weight;Body Weight decreased;Brain;Brain region;Brain Stem;Calcium;calcium indicator;Central Nervous System;Child;Chronic;Circulation;Complex;conditional knockout;Consensus;cost;Cyclic AMP;Data;Desire for food;detector;Dorsal;dorsal motor nucleus;Eating;Epidemic;Family;FDA approved;Fiber;G Protein-Coupled Receptor Signaling;G-Protein-Coupled Receptors;Genes;Genetic;global health;GLP-I receptor;Goals;GTP-Binding Protein alpha Subunits;GTP-Binding Protein alpha Subunits, Gs;Hour;Human;Image;improved;in vivo;in vivo calcium imaging;in vivo monitoring;in vivo two-photon imaging;Injections;insight;Intracellular Signaling Proteins;Knock-out;Knowledge;Lateral;Long-Term Effects;Measures;Mediating;Methods;Modernization;Morbidity - disease rate;mortality;Mus;Nature;neural;neural circuit;Neural Pathways;neuromechanism;neuronal circuitry;Neurons;Nucleus solitarius;Obesity;obesity treatment;optical imaging;optogenetics;Organ;parabrachial nucleus;Pathway interactions;Patients;Pattern;Peripheral;Peripheral Nervous System;Pharmaceutical Preparations;pharmacologic;Pharmacological Treatment;Pharmacotherapy;Photometry;Prevalence;prevent;Process;Proteins;receptor;Receptor Activation;receptor-mediated signaling;recruit;redshift;Reporting;Research;Resolution;response;Rodent;Rodent Model;Role;Satiation;Signal Pathway;Signal Transduction;Site;Slice;subcutaneous;Testing;Tetanus Toxin;Therapeutic;Time;tool;Toxin;Training;two photon microscopy;two-photon;Vagus nerve structure;Viral;Withdrawal;Work

PROJECT_TITLE: The role of Parabrachial nucleus and its inputs from Area prostrema in signaling Semaglutide-mediated weight loss and regulation of appetite

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 TWD-B (MK)]


NIH_SPENDING_CATS: Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Genetics;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza;Rare Diseases

ORG_CITY: BOWLING GREEN

ORG_NAME: WESTERN KENTUCKY UNIVERSITY

ORG_STATE: KY

PHR: Project Narrative Emerging pathogens are continuously evolving their infective mechanisms to alter host cellular responses to establish a niche and successful infection. In the wake of increase in Legionnaires outbreaks, the ability of Legionella pneumophila, to modulate diverse number of eukaryotic cell processes to survive and multiply in macrophages, is of public health concern. Thus, in-depth understanding of infection strategies from Legionella studies can help to design effective therapeutic strategies and preventive measures against intracellular bacterial pathogens.

PI_NAMEs: BANGA, SIMRAN  (contact)

PROGRAM_OFFICER_NAME: ERNST, NANCY L

PROJECT_TERMS: Alveolar;Alveolar Macrophages;Antibodies;Bacteria;Binding;Biochemical Pathway;Biological Assay;Biomedical Research;bisulfite;Cell Nucleus;Cell Physiology;Cells;Cellular biology;Centers for Disease Control and Prevention (U.S.);ChIP-seq;Chromatin;Co-Immunoprecipitations;Cytoplasm;Data;Data Analyses;design;differential expression;Disease Outbreaks;DNA;DNA analysis;DNA Methylation;Education;emerging pathogen;Engineering;Environment;Epigenetic Process;Eukaryotic Cell;European;Event;Exclusion;experience;experimental study;Functional disorder;Gene Expression;Gene Expression Alteration;Gene Expression Profile;Gene Expression Regulation;Genes;Genetic Transcription;Growth;histone modification;Histones;Host Defense Mechanism;Immune;Immune Evasion;Immune response;Immunoprecipitation;Infection;Inflammatory;Kentucky;Legionella;Legionella pneumophila;Legionnaires' Disease;Lung;Macrophage;Mammalian Cell;Mediating;Medicine;Methods;Methylation;methylation pattern;Microbiology;Modification;Molecular Biology;Mus;mutant;next generation sequencing;non-histone protein;Normal Cell;Notification;novel therapeutic intervention;Nuclear Extract;Nuclear Proteins;Organ;pathogen;Pathogenesis;pathogenic bacteria;Pathway interactions;Pneumonia;Population;Preventive measure;Process;protein expression;protein protein interaction;Proteins;Public Health;Research;response;RNA;RNA analysis;RNA Sequence Analysis;Role;Signal Transduction;Sorting;Structure of parenchyma of lung;System;Testing;therapeutically effective;Tissue-Specific Gene Expression;Tissues;transcriptome;transcriptome sequencing;Type IV Secretion System Pathway;undergraduate student;United States;United States National Academy of Sciences;Universities;Up-Regulation;Work

PROJECT_TITLE: Role of epigenetic changes in intracellular survival and replication of Legionell pneumophila

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 SPJ-D (M1)]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Neurodegenerative;Neurosciences;Physical Activity;Prevention;Regenerative Medicine;Rehabilitation;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_CITY: OMAHA

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: PROJECT NARRATIVE The number of older adults who are 60 years and older undergoing hematopoietic cell transplantation as part of cancer treatment has more than doubled in the past decade. Older adults undergoing transplants are at high risk of experiencing a decline in cognitive function afterwards that can affect day-to-day function and quality of life. Our project seeks to understand the relationship between cancer-related cognitive decline and Alzheimer’s Disease.

PI_NAMEs: KOLL, THUY  (contact)

PROGRAM_OFFICER_NAME: SERRA, MONICA CHRISTINE

PROJECT_TERMS: Affect;Age;aging process;Alzheimer's Disease;Alzheimer's disease risk;Alzheimer’s disease biomarker;Behavioral Sciences;Biological;Biological Markers;Brain;brain volume;Cancer Survivor;cancer therapy;cancer-related cognitive impairment;cardiorespiratory fitness;chemotherapy;Clinical;Cognitive;Cognitive aging;cognitive benefits;cognitive function;cognitive recovery;cognitive testing;Control Groups;cytokine;Data Collection;Diagnosis;Disease;Elderly;Exercise;exercise intervention;experience;Funding Opportunities;Future;Geriatrics;Goals;Hematologic Neoplasms;Hematopoietic Stem Cell Transplantation;high risk;human old age (65+);Impaired cognition;improved;Inflammation;Inflammatory;insight;Intervention;Intervention Studies;Knowledge;Life;Magnetic Resonance Imaging;Malignant Neoplasms;Measures;Methods;modifiable behavior;neuropathology;Neurosciences;neurotoxic;novel;older adult;older patient;Oncology;parent project;Pathway interactions;patient population;Patients;Performance;Phase;Physical activity;Physical Function;Play;Population;Prevalence;Prevention;Process;Quality of life;Recovery;Regimen;Research;Risk;Risk Factors;Role;Sampling;Structure;Testing;Transplantation;transplantation therapy;United States;Waiting Lists;Whole-Body Irradiation

PROJECT_TITLE: Promoting physical activity to improve cognitive function in older adults undergoing hematopoietic cell transplantation


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PHR: PROJECT NARRATIVE Nearly half of adults in the United States have or are at risk of developing type 2 diabetes. The overall goal of this community-engaged research is to examine the efficacy of an innovative couple-based lifestyle intervention to prevent type 2 diabetes that is applicable to a broad range of partnered adults in the United States. By simultaneously targeting lifestyle and perceived support from romantic partners, there is a high likelihood of creating lasting changes in both.

PI_NAMEs: BAUCOM, KATHERINE JANE WILLIAMS (contact)

PROGRAM_OFFICER_NAME: CENTER, MAUREEN MONAGHAN

PROJECT_TERMS: Acceleration;Address;Adult;Affect;Area;Behavior;Behavior Therapy;Behavioral;Body Weight decreased;Clinical;clinically significant;Collaborations;Communities;community advisory board;community engaged approach;community engaged research;Community Healthcare;cost;Couples;design;Diabetes Mellitus;Diabetes prevention;diabetes prevention program;diabetes risk;Disparity;Educational Curriculum;efficacy evaluation;efficacy trial;Ensure;Environment;ethnic minority population;Ethnic Population;experience;Family;Feasibility Studies;follow-up;Funding;Glycosylated hemoglobin A;Goals;Health;health care settings;health disparity;health inequalities;high risk;high risk population;Home environment;improved;Individual;Information Dissemination;innovation;Intervention;intervention program;Intervention Trial;Life Style;lifestyle factors;lifestyle intervention;Maintenance;Measures;Mediating;Medical;member;Methods;Modeling;moderate-to-vigorous physical activity;National Institute of Diabetes and Digestive and Kidney Diseases;Non-Insulin-Dependent Diabetes Mellitus;nutrition;Obesity;Outcome;Participant;participant retention;patient oriented;Phase;Physical activity;pilot trial;Positioning Attribute;prevent;Prevention;Preventive;primary outcome;Primary Prevention;programs;Protocols documentation;Quality of life;racial minority population;racial population;Randomized;randomized, clinical trials;recruit;Reporting;Research;retention rate;Risk;Risk Factors;Sampling;satisfaction;secondary outcome;Signal Transduction;Site;Sleep;social;Social Environment;Stress;therapy design;therapy development;Time;United States;Weight;Work

PROJECT_TITLE: PreventT2 Together: Examing the efficacy of couple-based lifestyle intervention to prevent type 2 diabetes

STUDY_SECTION: LCBH

STUDY_SECTION_NAME: Lifestyle Change and Behavioral Health Study Section[LCBH]


ADMINISTERING_IC: HL

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cardiovascular;Heart Disease;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: IRVINE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: PROJECT NARRATIVE (of Parent Grant: R01HL164348)  Stem cell-based regenerative therapies or in vitro investigations of cardiovascular disease pathophysiology, drug screening, and toxicology studies heavily rely on stem cell quality. Here, peptide nanostructures will be engineered to enable cells to be light responsive in a wireless and non-genetic manner, which can ultimately be utilized as a strategy for converting optical cues to stimulatory signals that can improve the structural and functional maturity of human stem cell-derived cardiomyocytes. With this new approach, we hope to alleviate the major technical barrier of CM immaturity, and therefore, better enable stem cell-based cardiovascular research and related fields to flourish.

PI_NAMEs: ARDOÑA, HERDELINE ANN MALLARI (contact)

PROGRAM_OFFICER_NAME: THAKAR, RAHUL GAUTAM

PROJECT_TERMS: Action Potentials;Address;Adult;Animal Model;Anisotropy;Architecture;Automobile Driving;Behavior;Binding;biomaterial interface;Biophysics;Calcium;Cardiac;Cardiac Myocytes;cardiac tissue engineering;Cardiovascular Diseases;Cardiovascular system;Cell Culture Techniques;Cell Survival;Cells;Charge;Chemical Stimulation;chromophore;combinatorial;conditioning;Cues;design;disease mechanisms study;drug discovery;Drug Screening;Electric Stimulation;Electrodes;Engineering;Ensure;Epitopes;extracellular;Film;Frequencies;Functional disorder;Gene Expression;Generations;genetically modified cells;Goals;Heart Diseases;Heart Injuries;Heating;high throughput screening;human induced pluripotent stem cells;human stem cell-derived;improved;In Vitro;indexing;infection risk;innovation;instrumentation;Investigation;irradiation;Light;Measurement;Measures;Mechanics;Mediating;Metabolism;Methods;Microelectrodes;minimally invasive;Modeling;Monitor;monomer;Muscle Cells;Nanostructures;Neonatal;non-genetic;novel strategies;Optics;optogenetics;parent grant;Pattern;Peptide Library;Peptides;personalized medicine;Phenotype;Polymers;Process;Protocols documentation;Rattus;Reaction;regenerative therapy;Reporting;Research;Resolution;response;Risk Assessment;Risk Reduction;scale up;Side;Signal Transduction;Source;spatiotemporal;species difference;stem;stem cell based approach;stem cells;Stimulus;Stress;Structure;success;Surface;Technology;temporal measurement;Testing;Therapeutic;Tissues;Toxicology;Transducers;Transfection;Ventricular;wireless

PROJECT_TITLE: Diversity Supplement: Optically Promoting Cardiac Maturation Using Engineered Peptides


NIH_SPENDING_CATS: Chronic Pain;Clinical Research;Dissemination and Implementation Research;Emergency Care;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Hematology;Pain Research;Patient Safety;Rare Diseases;Sickle Cell Disease;Social Determinants of Health

ORG_CITY: ROCHESTER

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: PROJECT NARRATIVE Guidelines recommend use of individualized care plans (ICPs) as an important tool for improving sickle cell disease (SCD) care quality based on data from the emergency department. However, literature addressing ICP use for inpatient care is sparse and we do not know the best way to use ICPs for hospitalized patients with SCD. This proposal will engage adults with SCD and healthcare team members in 1) adapting ICPs from the emergency department to the inpatient care setting and 2) testing the feasibility of using ICPs for inpatient SCD care.

PI_NAMEs: JENKINS, ASHLEY  (contact)

PROGRAM_OFFICER_NAME: BRUNO, FERNANDO PEREIRA

PROJECT_TERMS: acceptability and feasibility;Accident and Emergency department;Acute;acute chest syndrome;Address;Adult;Affect;American;Analgesics;Area;arm;Attitude;Automobile Driving;Award;Black race;care episode;career;career development;Caring;Clinical;clinical care;Clinical Sciences;Communities;Community Hospitals;cost;Data;design;Development Plans;Discipline;Disease;Education;Effectiveness;effectiveness evaluation;effectiveness/implementation trial;Emergency department visit;Emergency Medicine;Equity;evidence base;experience;Feasibility Studies;feasibility testing;Fire - disasters;Funding;Goals;Guidelines;health equity;health equity promotion;health information technology;Health system;Healthcare;Hematological Disease;Hematology;hospital care;Hospitalists;Hospitalization;hospitalization rates;Hospitals;human centered design;implementation barriers;implementation facilitators;implementation framework;implementation outcomes;implementation research;implementation science;implementation strategy;improved;Inherited;inpatient service;Inpatients;Internal Medicine;Intervention;intervention mapping;Interview;Journals;K-Series Research Career Programs;Knowledge;Length of Stay;Life;Literature;marginalized population;Measures;Medical Care Team;Medical center;medical specialties;Medicine;member;Mentors;Mentorship;Methods;mortality;mortality risk;National Heart, Lung, and Blood Institute;Outcome;Output;Pain;Pain management;pain symptom;Patient Care;Patient Care Planning;patient engagement;patient oriented;Patients;Pediatrics;people of color;personalized care;Persons;Pharmaceutical Preparations;Physicians;pilot test;Poverty;preference;Process;Protocols documentation;prototype;Quality of Care;racial bias;Recommendation;Records;Research;Research Personnel;Scientist;Secure;Sickle Cell;Sickle Cell Anemia;Site;skills;social stigma;Source;Standardization;Stigmatization;Stroke;Structure;symposium;Testing;Time;tool;Training;Transfusion;Translating;Translational Research;Universities;University resources;Urban Community;usability;Wait Time;Work

PROJECT_TITLE: Formative Implementation Research on Translating Evidence to Hospital Care for People Living With Sickle Cell Disease (FIRES)

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-O (M3)]


ADMINISTERING_IC: EY

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL EYE INSTITUTE

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: NARRATIVE  The long-term mission of the Vanderbilt Vision Research Center (VVRC) is to leverage novel technologies, strategies, and partnerships to (1) understand the biological substrates of vision and mechanisms of diseases affecting the visual system and (2) leverage this knowledge to inform, develop, and test new therapeutic strategies for vision-threatening conditions. Proposed service modules will support and enhance innovative and novel approaches spanning genes and proteins to brain circuits and behavior to better understand vision and ways to preserve it in aging and disease.

PI_NAMEs: CALKINS, DAVID J. (contact)

PROGRAM_OFFICER_NAME: GOVER, TONY DOUGLAS

PROJECT_TERMS: Academic Medical Centers;Affect;Aging;animal imaging;Animal Model;Appointment;Arts;Attention;Award;Behavior;Biocompatible Materials;Bioinformatics;Biological;Biological Markers;Brain;career;Caring;catalyst;cellular imaging;Center Core Grants;Clinical;Cognition;Collaborations;college;Core Grant;Data;Data Analyses;data management;Data Management Resources;data platform;differential expression;digital;Discipline;Disease;DNA;Educational Activities;Electron Microscopy;Engineering;Ensure;Environment;Equipment;Eye;Faculty;Faculty Recruitment;Fostering;Funding;Funding Agency;Genes;Genomics;Goals;Grant;Growth;high throughput analysis;Histology;Image;Image Analysis;image processing;imaging capabilities;imaging modality;imaging science;improved;Informatics;Infrastructure;innovation;Institution;instrumentation;interdisciplinary collaboration;Investigation;Knowledge;Laboratories;Laser Scanning Confocal Microscopy;Maintenance;Mammals;Mass Spectrum Analysis;medical schools;member;Memory;Mentored Clinical Scientist Development Program;Mission;National Eye Institute;new growth;new technology;nonhuman primate;novel;novel strategies;novel therapeutic intervention;operation;Ophthalmology;Paper;Pathology;Patients;Performance;Post-Translational Protein Processing;Pre-Clinical Model;Preparation;preservation;Productivity;programs;protein protein interaction;Proteins;Proteomics;Publications;Publishing;Recording of previous events;recruit;Research;Research Activity;Research Personnel;Resolution;Resource Sharing;Resources;RNA;Schools;Science;Scientist;Secure;Services;Stains;Structure;System;Technology;Testing;Time;Tissues;Training;Training and Education;Training Programs;translational study;Universities;Vertebral column;Vision;vision development;Vision research;vision science;Visual;Visual attention;visual cognition;visual dysfunction;Visual System;web page

PROJECT_TITLE: Core Grant in Vision Research

STUDY_SECTION_NAME: Special Emphasis Panel[ZEY1 VSN (07)]


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision

PROJECT_TERMS: Academic Medical Centers;Accountability;Affect;Animal Model;Appointment;Arts;Biological;Budgets;Businesses;cellular imaging;Cognitive;college;Communication;Core Grant;data management;Databases;Disease;Education;Educational Activities;electronic data;Electronic Mail;Electronics;Engineering;Equipment and Supplies;Equity;Event;Expenditure;Eye;Faculty;Faculty Recruitment;Funding;Grant;Histology;Human Resources;Individual;Informatics;innovation;Institution;Instruction;instrumentation;interdisciplinary collaboration;Knowledge;Leadership;Link;Mass Spectrum Analysis;Mediating;medical schools;meetings;member;Mission;Modality;Monitor;new technology;novel therapeutic intervention;Paper;Pathology;Process;Proteomics;Recording of previous events;Records;Research;Research Activity;Research Personnel;Resource Allocation;Sampling;Scholarship;Schools;Science;Services;Shipping;Surveys;symposium;System;Testing;Universities;Update;Vision;Vision research;vision science;visual information;Visual System;voucher;web page;web platform;web site

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Biomedical Imaging;Eye Disease and Disorders of Vision;Neurosciences

PI_NAMEs: CONSTANTINIDIS, CHRISTOS  (contact)

PROJECT_TERMS: Anesthesia procedures;animal care;animal imaging;Animal Model;animal model development;Animal Technicians;Animals;Award;base;Behavior;Brain region;Breeding;career;Caring;Catheters;Cognitive;cohort;Consultations;Core Grant;Custom;Development;Ensure;experience;experimental study;Extramural Activities;Faculty;Fluid Therapy;Funding;Galago Genus;Gases;Grant;Human Resources;IACUC;Image;Imaging Device;imaging facilities;imaging modality;imaging science;Individual;innovation;instrument;interest;Intratracheal Intubation;Investigation;Laboratories;Laboratory Personnel;longitudinal care;Longitudinal Studies;Maintenance;Mammals;member;Modality;model development;multimodality;non-invasive imaging;nonhuman primate;novel;Operating Rooms;Operative Surgical Procedures;Optics;Perception;Physiology;Positron-Emission Tomography;Procedures;Prosimii;protocol development;Protocols documentation;Psychology;Publications;Recovery;Research;Research Personnel;Research Training;Resources;Rodent;Roentgen Rays;Schedule;Scholarship;Scientist;Service delivery model;Services;single photon emission computed tomography;skills;Sterilization;Structure;success;System;Techniques;Training;Training and Education;Tupaiidae;ultrasound;United States Department of Agriculture;United States National Institutes of Health;Universities;Vision;Vision research;Visual;Visual Pathways;Work

PROJECT_TITLE: Animal Models


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

PROJECT_TERMS: Antibodies;Area;Biochemical;career;Cells;Cognitive;Collaborations;Communities;Computer software;Core Grant;cresyl violet;cryostat;Databases;digital;Disease;Dissection;Doctor of Philosophy;electronic data;Ensure;epon;extracellular;Extramural Activities;Eye;Faculty;Freezing;Frozen Sections;Funding;Goals;Grant;Harvest;Health;Hematoxylin and Eosin Staining Method;Histologic;Histological Labelings;histological stains;Histological Techniques;Histology;Human Resources;Image;image processing;Individual;Institution;Instruction;interest;Label;Laboratories;Link;member;Methylene blue;Microscopy;Microtome - medical device;Modality;Molecular;Oils;Ophthalmology;Optics;Paraffin Embedding;Pathology;Perfusion;Plastic Embedding;Preparation;Procedures;Productivity;Protocols documentation;Publications;Research;Research Personnel;Resolution;Resources;Rotation;sample fixation;Sampling;Scholarship;Scientist;Sepharose;Services;Signal Transduction;Slide;Staining and Labeling;Stains;Structure;Structure-Activity Relationship;student training;Students;Surveys;Thick;Thinness;Tissue Embedding;tissue preparation;Tissues;Tolonium chloride;Training;Vision;Vision research;vision science;Visual Pathways;Visual System;web page;web platform

PROJECT_TITLE: Histology and Pathology


NIH_SPENDING_CATS: Bioengineering;Eye Disease and Disorders of Vision;Neurosciences

PROJECT_TERMS: Behavior;Brain region;career;Collaborations;Computer software;Computer Workstations;Core Grant;cost;Custom;Data;Data Analyses;Data Collection;Databases;design;digital;Doctor of Philosophy;electronic data;Electronics;Engineering;Ensure;Equipment;experimental study;Extramural Activities;fabrication;Faculty;Funding;Goals;Hour;Human Experimentation;Human Resources;innovation;Institution;Instruction;instrumentation;interest;Investigation;Laboratories;Link;Maintenance;medical specialties;member;Methods;Modality;Modification;nonhuman primate;Perception;Physiology;Prevention;Procedures;programs;Progress Reports;Publications;repaired;Research;Research Personnel;Resources;Rodent;Scholarship;Scientist;Services;Source;Structure;Surveys;System;Time;Vision;Vision research;Visual;web page;web platform;web site;Work

PROJECT_TITLE: Instrumentation Core


NIH_SPENDING_CATS: Bioengineering;Eye Disease and Disorders of Vision;Networking and Information Technology R&D (NITRD);Neurosciences

PI_NAMEs: TONG, FRANK  (contact)

PROJECT_TERMS: Administrator;Animals;archive data;Archives;awake;Behavior;Behavioral;Bioinformatics;career;Clinical;cloud based;cloud platform;Cognitive;Collaborations;Complex;Computer Hardware;Computer Models;Computer software;Computer Systems;computerized;Computers;Core Grant;Custom;Data Analyses;data archive;Data Collection;data format;data management;data pipeline;Data Set;data sharing;Data Storage and Retrieval;Databases;design;Development;digital platform;digital solutions;Doctor of Philosophy;electronic data;Equipment;Exclusion;experimental study;Extramural Activities;Face;Faculty;Funding;Goals;Guidelines;Human;human model;Human Resources;Human Subject Research;Image;innovation;Institution;instrument;instrumentation;interest;Internet;Investigation;Laboratories;laboratory experiment;large datasets;Link;Maintenance;medical specialties;member;multi-electrode arrays;neurophysiology;nonhuman primate;Online Systems;open data;Physiological;Procedures;Productivity;Progress Reports;Publications;Research;Research Personnel;Research Support;Resources;Scholarship;Science;Scientist;Security;Services;Surveys;System;Technology;United States National Institutes of Health;Vision;Vision research;Visual;visual cognition;web app;web page;web platform;web server;web site

PROJECT_TITLE: Computation and Data Management


NIH_SPENDING_CATS: Biotechnology;Eye Disease and Disorders of Vision;Genetics;Human Genome

PROJECT_TERMS: Accounting;Animals;Bioinformatics;Biometry;career;Cells;ChIP-seq;Collaborations;Complex;Computer software;Core Grant;cost;Custom;Data;Data Analyses;Data Storage and Retrieval;Databases;discount;Disease;DNA;Doctor of Philosophy;Ensure;Equipment;exome sequencing;Experimental Designs;Extramural Activities;Faculty;Funding;Genes;Genetic;Genetic study;genome sequencing;genome wide association study;genomic data;Genomics;Genotype;genotyping technology;Goals;Grant;Health Services Accessibility;Human;Human Resources;Individual;Informatics;Institution;interest;Laboratories;Libraries;Link;Location;Measures;Medical Genetics;member;Molecular Genetics;next generation sequencing;Nucleic Acids;Patients;Pattern;pre-clinical;Publications;quality assurance;Quality Control;remote monitoring;Research;Research Design;Research Personnel;Resolution;Resources;RNA;RNA analysis;Running;Sampling;Scholarship;Science;Scientist;Secure;Security;Services;Single Nucleotide Polymorphism;Site;student training;System;Technical Expertise;Technology;Time;Tissues;transcriptome sequencing;Transgenic Animals;Translating;treatment response;Variant;Vision;Vision research;vision science;Visual Pathways;Visual System;whole genome

PROJECT_TITLE: Sequencing and Informatics


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Eye Disease and Disorders of Vision;Networking and Information Technology R&D (NITRD);Neurosciences

PROJECT_TERMS: 3-Dimensional;Accounting;archive data;Authorization documentation;Biochemical;career;Cells;Cellular biology;cellular imaging;centralized portal;Collaborations;Collection;Communication;Computer software;Consultations;Core Grant;cost;Data;data archive;Data Set;Data Storage and Retrieval;Developmental Biology;discount;Doctor of Philosophy;Documentation;Electron Microscopy;Ensure;Environment;Equipment;extracellular;Extramural Activities;Faculty;flexibility;Fluorescence;Funding;Goals;Grant;Guidelines;Histologic;Hour;Human Resources;Image;Image Analysis;imaging modality;imaging platform;Imaging technology;improved;Institution;interest;Label;Laboratories;Laser Scanning Confocal Microscopy;Leadership;Light;light microscopy;Lighting;Location;Manuals;Medical center;member;Microscope;microscopic imaging;Microscopy;Modality;Modification;Molecular;Monitor;operation;Optics;professor;Publications;reconstruction;Research;Research Personnel;Resolution;Resource Sharing;Resources;Running;Sampling;Scholarship;Scientist;Secure;Services;Signal Transduction;single molecule;Software Tools;spectrograph;Speed;Structure;Structure-Activity Relationship;student training;superresolution imaging;superresolution microscopy;Supervision;System;Technical Expertise;Testing;Time;Tissue Sample;Tissues;Training;Translating;United States National Institutes of Health;Vision;Vision research;vision science;Visual Pathways;visual processing;Visual System

PROJECT_TITLE: Cell Imaging and Analysis


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Eye Disease and Disorders of Vision

PI_NAMEs: SCHEY, KEVIN L (contact)

PROJECT_TERMS: Accounting;Bioinformatics;career;clinical infrastructure;clinical training;Collaborations;Communities;Computer software;Core Grant;cost;data acquisition;Data Analyses;discount;Disease;Doctor of Philosophy;Elements;Ensure;Equipment;Experimental Designs;experimental study;Extramural Activities;Faculty;Funding;Grant;Human Resources;Image;imaging facilities;Individual;Inductively Coupled Plasma Mass Spectrometry;Institution;Instruction;instrumentation;interest;Label;Laboratories;Lipids;liquid chromatography mass spectrometry;Liquid substance;Location;Maps;mass spectrometric imaging;Mass Spectrum Analysis;Measures;member;metabolomics;Methodology;Methods;Mission;Molecular;molecular imaging;Patients;Pattern;Peptides;Pharmaceutical Preparations;Post Translational Modification Analysis;Post-Translational Protein Processing;Preparation;professor;Protein Analysis;protein expression;protein protein interaction;Proteins;Proteomics;Protocols documentation;Publications;Research;Research Personnel;Resolution;Resources;Sampling;Scholarship;Scientist;Services;small molecule;Spatial Distribution;Stable Isotope Labeling;Statistical Data Interpretation;student training;Students;System;Technical Expertise;Techniques;Technology;Tissue imaging;Tissues;Training;Transgenic Animals;Translating;treatment response;Vision;Vision research;vision science;Visual Pathways;Visual System

PROJECT_TITLE: Mass Spectrometry and Proteomics


NIH_SPENDING_CATS: Bioengineering;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Project Narrative The Fiehn laboratory at UC Davis will collaborate with the Metz laboratory at PNNL and the Evans laboratory at University of Michigan to develop and validate the LC-BinBase database as generic workflow for liquid chromatography-mass spectrometry data in metabolomics and lipidomics. We aim to standardize metabolomics data processing across different mass spectrometry instruments, for different data acquisition methods, and across laboratories. We will validate result data for biofluids (plasma, urine, saliva), for different animal tissues and for cell cultures to yield reproducible and harmonized data sets that are easier to interpret for biomedical scientists.

PI_NAMEs: EVANS, CHARLES ROBERT;FIEHN, OLIVER  (contact);METZ, THOMAS O

PROGRAM_OFFICER_NAME: YU, GUOQIN

PROJECT_TERMS: Algorithms;Amniotic Fluid;analytical method;Animal Model;animal tissue;Automatic Data Processing;Automobile Driving;Benchmarking;Biological;Biological Assay;Biological Testing;biomedical scientist;cell type;Characteristics;Chromatography;Classification;cloud based;Collaborations;Communities;Computer software;computerized data processing;Consensus;Data;data access;data acquisition;Data Analyses;data analysis pipeline;data harmonization;data interoperability;Data Reporting;Data Set;data standards;Databases;denoising;disease phenotype;Educational workshop;Elements;Entropy;Event;Feedback;Genetic;hydrophilicity;improved;Informatics;instrument;instrumentation;interest;ion mobility;Ions;Laboratories;lipidomics;Lipids;liquid chromatography mass spectrometry;Machine Learning;Manuals;mass spectrometer;Mass Spectrum Analysis;metabolomics;Metadata;Methods;Michigan;Mus;Names;next generation;Normal Statistical Distribution;Organ;Pacific Northwest;Pathway Analysis;Pilot Projects;Plasma;Probability;Proteomics;prototype;Reporting;repository;Reproducibility;Research Personnel;Residual state;Resolution;Resources;reversed phase chromatography;Saliva;Standardization;Surveys;Testing;Time;tissue/cell culture;tool;transcriptomics;Universities;Urine;usability;Validation;Vendor;Water;Work

PROJECT_TITLE: A reproducible database for untargeted metabolomics data processing across laboratories

STUDY_SECTION: BDMA

STUDY_SECTION_NAME: Biodata Management and Analysis Study Section[BDMA]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Diabetes;Eye Disease and Disorders of Vision;Genetics;Neurosciences;Orphan Drug;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Rare Diseases

ORG_CITY: INDIANAPOLIS

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: PROJECT NARRATIVE Aberrant retinal neovascularization impairs visual function in various disease statements including retinopathy of prematurity (ROP) and proliferative diabetic retinopathy (PDR). Although intravitreal (IVT) injections of anti- VEGF treatment options exist, many patients are refractive to therapy due to the complex pathogenesis of neovascularization, and there is a high treatment burden associated with IVT injections. Thus, the proposed research will investigate the role of the redox function of Ref-1 in retinal neovascularization and investigate the effects of an orally delivered small molecule inhibitor of Ref-1 as a novel therapeutic for retinal neovascularization.

PI_NAMEs: HARTMAN, GABRIELLA  (contact)

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: Adult;Age;angiogenesis;Angiogenesis Inhibitors;Area;Biological Assay;Biological Factors;Blindness;Child;Choroidal Neovascularization;Co-Immunoprecipitations;combat;Complex;Cysteine;Data;Deoxyribonuclease I;Diabetes Mellitus;Diabetic Retinopathy;Disease;Down-Regulation;endonuclease;Endothelial Cells;Exhibits;Eye;Eye diseases;FZD1 gene;FZD4 gene;Gene Expression;Genes;Genetic;Goals;HIF1A gene;Human;human RNA sequencing;Immunofluorescence Immunologic;improved;in vitro Assay;in vivo;Inflammatory;inhibitor;insight;Insulin-Dependent Diabetes Mellitus;interest;intravitreal injection;Knowledge;Lasers;Lead;Link;Medical;Modeling;Molecular;mouse model;mRNA Expression;Mus;neovascular;neovascularization;new therapeutic target;novel;novel therapeutic intervention;novel therapeutics;Oral;Oral Administration;oxidation;Oxidation-Reduction;Oxygen;Pathogenesis;Pathologic Neovascularization;Pathology;Pathway interactions;Patients;pharmacologic;Pharmacological Treatment;preterm newborn;Prevalence;proliferative diabetic retinopathy;protein expression;Proteins;Quality of life;receptor;Regulation;Reporter;Research;Resistance;Retina;Retinal Diseases;Retinal Neovascularization;Retinopathy of Prematurity;Role;Severity of illness;Signal Transduction;small molecule;small molecule inhibitor;Societies;spatiotemporal;STAT3 gene;Testing;Therapeutic;Therapeutic Effect;therapy resistant;Tissues;transcription factor;transcriptome sequencing;Treatment Factor;Treatment Protocols;treatment response;Up-Regulation;Vascular Diseases;Vascular Endothelial Growth Factors;Vision;Visual impairment;Western Blotting;WNT Signaling Pathway

PROJECT_TITLE: Ref-1 in Retinal Neovascularization


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

ORG_CITY: EUGENE

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF OREGON

PHR: PROJECT NARRATIVE This project will study the impact that natural locomotion has on two key visual areas in the mammalian brain: primary visual cortex and superior colliculus. It will therefore have a direct impact on our understanding of how the visual system functions under natural conditions, thereby contributing to an overall greater understanding of active vision as well as visual impairment.

PI_NAMEs: SHARP, SHELBY L (contact)

PROGRAM_OFFICER_NAME: CLAYTON, EDWIN C

PROJECT_TERMS: active vision;Anesthesia procedures;Animals;area striata;Articular Range of Motion;Attention;awake;Behavior;Brain;Brain region;cell type;Cells;Chronic;Electrophysiology (science);Environment;experimental study;extrastriate visual cortex;Eye Movements;Future;gaze;Head;Head Movements;Implant;in vivo;insight;Investigation;Laboratories;Locomotion;Measures;Methods;Motion;Movement;Mus;Names;neural;neural circuit;Neurons;novel;Perception;Play;Process;Property;Resolution;response;restraint;Retina;Role;sample fixation;sensory input;Silicon;spatial integration;Stream;superior colliculus Corpora quadrigemina;Time;treadmill;Vision;Visual;Visual Cortex;Visual impairment;visual neuroscience;visual processing;visual receptive field;visual stimulus;Visual System

PROJECT_TITLE: The Impact of Natural Locomotion on Visual Processing


NIH_SPENDING_CATS: Genetics;Precision Medicine

ORG_CITY: CORVALLIS

ORG_NAME: OREGON STATE UNIVERSITY

PHR: PROJECT NARRATIVE The proposed research is relevant to public health and aligns with the NIH’s mission because understanding the biological forces that shape and underlie variation in health outcomes is a necessary step toward personalized medicine. The proposed work will combine experimental evolution, model systems, genetic sequencing, and molecular phenotyping to study what drives differences in rates of senescence and type 2 diabetes susceptibility between individuals. Moreover, findings on how the relationship between different levels of biological organization impact organismal phenotypes could be generally useful for understanding variation in health-related traits.

PI_NAMEs: PHILLIPS, MARK A (contact)

PROGRAM_OFFICER_NAME: ADKINS, RONALD

PROJECT_TERMS: 3-Dimensional;Address;Age;Aging;Biological;Biological Models;Biology;Complex;Controlled Environment;Data;Diet;Disease;Drosophila genus;Electron Microscopy;Evolution;experimental study;Generations;Genes;Genetic;Genetic Drift;Genetic Variation;Genomics;Goals;Health;Human;improved;Individual;insight;Intervention;life history;metabolomics;Mission;molecular phenotype;Non-Insulin-Dependent Diabetes Mellitus;Outcome;Pattern;personalized medicine;Phenotype;Population;Predisposition;pressure;Public Health;Research;segregation;senescence;Shapes;success;sugar;System;Testing;Time;trait;transcriptomics;Translating;United States National Institutes of Health;Variant;Work

PROJECT_TITLE: Combining experimental evolution and molecular phenotyping to understand variation in organismal phenotypes

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Biotechnology;Kidney Disease;Orphan Drug;Rare Diseases;Urologic Diseases

ORG_CITY: AUSTIN

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

PHR: Project Narrative This project will determine if human enzyme therapy is a tractable therapeutic strategy for cystinuria, and therefore has the potential to improve quality of life for the thousands of patients who suffer from this rare disease. It may also relieve a significant burden on the public healthcare system, as patients with this disease undergo numerous medical and surgical interventions throughout their lifetimes. Long term testing will be employed to ensure that this therapeutic approach is safe and well tolerated.

PI_NAMEs: GEORGIOU, GEORGE GEORGIOU (contact)

PROGRAM_OFFICER_NAME: PITTENGER, STEVEN THEODORE

PROJECT_TERMS: absorption;Adherence;Age;Amino Acids;Animal Model;Animals;Back;Behavior;behavior measurement;Blood;blood filter;Body Weight;burden of illness;checkpoint inhibition;Chronic;Chronic Kidney Failure;circulating biomarkers;Circulation;Clinical;clinical development;comparison control;Control Groups;Cyst;Cysteine;Cystine;Cystinuria;Development;Disease;Dose;drug candidate;effective therapy;Engineering;enzyme therapy;Enzymes;Event;Excision;Exhibits;experience;Exposure to;Gout;Growth;Health;health assessment;Healthcare Systems;Homeostasis;Homocysteine;Homocystinuria;Human;Human Engineering;human model;Hydration status;Impairment;improved;invention;Joints;Kidney;Kidney Calculi;Knockout Mice;Lithiasis;Longitudinal Studies;male;Malignant Neoplasms;Measures;Mediating;Medical;Metabolic;Metabolic Diseases;metabolomics;Modality;mouse model;Mus;novel;Operative Surgical Procedures;Organ;Outcome;Pathology;Patient Compliance;Patients;Phase I/II Trial;Phenotype;Physiological;Plasma;preclinical development;prevent;programs;Public Health;Quality of life;Rare Diseases;Recurrence;Regimen;Research;Research Personnel;Safety;Secondary to;side effect;Solubility;Sulfhydryl Compounds;Testing;Therapeutic;therapeutic enzyme;therapeutic evaluation;Therapeutic Intervention;Time;Tissues;Toxic effect;Toxicology;Treatment Efficacy;Urate Oxidase;Uric Acid;Urinary tract;Urine;Validation;Wild Type Mouse;X-Ray Computed Tomography

PROJECT_TITLE: Effective treatment of cystinuria with a novel engineered cyst(e)ine-degrading human enzyme therapy

STUDY_SECTION_NAME: Special Emphasis Panel[ZTR1 RD-1 (01)]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Chronic Pain;Clinical Research;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurosciences;Pain Research;Pediatric;Prevention;Rehabilitation;Sleep Research;Social Determinants of Health

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

PHR: PROJECT NARRATIVE More than 250,000 children survive pediatric intensive care unit (PICU) hospitalization each year, and many suffer persistent problems with pain and sleep that can significantly impact long-term health and well-being. Our study will be the first to longitudinally evaluate risk factors for chronic pain and sleep disturbances in PICU survivors and to determine how pain and sleep impact key long-term executive function outcomes in these children. Data from our study will inform interventions aimed at identifying and treating pain and sleep problems to optimize PICU survivorship.

PI_NAMEs: WILLIAMS, CYDNI NICOLE (contact)

PROGRAM_OFFICER_NAME: DIXIT, SHILPY

PROJECT_TERMS: Academic achievement;actigraphy;Acute;Acute Pain;Address;Adult;Affect;aged;Area;Attention;Behavior;biopsychosocial;Brain;Caregivers;Cessation of life;Child;Childhood;chronic pain;chronic pain patient;clinically significant;Cognitive;cognitive process;cognitive reappraisal;Collaborations;Critical Illness;Data;design;Development;Diagnosis;disability;Disease;emotion regulation;Enrollment;executive function;experience;flexibility;functional disability;Functional disorder;Future;Health;Hospitalization;Hospitals;Hyperalgesia;Impaired cognition;improved;Injury;Intensive Care;Interdisciplinary Study;Intervention;Knowledge;Link;long term recovery;Longitudinal cohort study;Longitudinal Studies;Maintenance;Measures;Mediating;Mediator;meetings;modifiable risk;Morbidity - disease rate;Neurologic Dysfunctions;novel;opioid misuse;Outcome;Outcomes Research;Pain;Pain intensity;Pain management;Pain Research;pain-related disability;Patients;Pediatric Intensive Care Units;Performance;Persistent pain;Personal Satisfaction;Persons;Population;Prevalence;Prevention;Process;psychologic;psychosocial;Psychosocial Factor;psychosocial wellbeing;Quality of life;Recording of previous events;Recovery;Reporting;Research;Research Priority;Risk;Risk Factors;Severity of illness;Short-Term Memory;Sleep;Sleep Disorders;Sleep disturbances;social engagement;social vulnerability;Surveys;Survivors;survivorship;System;Testing;Time;United States;United States National Institutes of Health;Well in self;Work;Youth

PROJECT_TITLE: Sleep, pain, and recovery in kids after pediatric intensive care (SPARK-PICU)

STUDY_SECTION: BMHO

STUDY_SECTION_NAME: Biobehavioral Medicine and Health Outcomes Study Section[BMHO]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Services;Pediatric;Prevention;Violence Against Women;Violence Research;Women's Health Research

ORG_DEPT: FAMILY MEDICINE

PHR: PROJECT NARRATIVE Female genital mutilation/cutting (FGM/C) affects girls and women throughout the world, with 3 million girls cut each year, and resulting in significant reproductive, sexual, and mental health needs for impacted patients. Implementation and evaluation of healthcare provider training programs are a top research priority to meet these needs while also creating systemic change. This project aims to conduct a rigorous (1) needs assessment, (2) build a training curriculum, and (3) conduct a randomized controlled trial of midwifery, nursing, and medical students in Tanzania, a high prevalence FGM/C country.

PI_NAMEs: CONNOR, JENNIFER JO (contact);MASSAE, AGNES

PROGRAM_OFFICER_NAME: AHN, HELENA HYESOOK

PROJECT_TERMS: Address;Adopted;Affect;Africa;Ally;Area;arm;Attention;Attitude;Blinded;Caring;Climate;clinical care;clinical examination;Clinical Skills;Communication;Communities;comparison control;Counseling;Country;COVID-19 pandemic;Development;Discipline;Discipline of Nursing;Dyspareunia;Educational Curriculum;Educational process of instructing;effectiveness evaluation;effectiveness study;Emergency Situation;Ethics;Evaluation;experience;Faculty;Female Genital Mutilation;Focus Groups;follow-up;Genitalia;Geographic Locations;girls;Goals;Health;health care delivery;health care needs assessment;health disparity;Health Personnel;Health Professional;health training;Healthcare;Hemorrhage;High Prevalence;improved;Individual;Infant;Infant Care;Infection;Infibulations;interest;Intervention;Interview;Knowledge;Legal;Low Prevalence;Medical;Medical Students;Mental Health;Midwifery;Modeling;Mothers;Needs Assessment;Neonatal Intensive Care;Nursing Students;obstetrical complication;Outcome;Pain;Participant;Patients;Primary Prevention;Procedures;Program Effectiveness;programs;psychologic;Published Comment;Randomized;Randomized, Controlled Trials;Recording of previous events;Reproductive Health;Research;Research Priority;Risk;Sampling;Science;screening;secondary analysis;Sex Functioning;Sexual Health;single-blind trial;skills;social;Structure;Students;Surveys;Tanzania;Testing;Trainers Training;Training;Training Programs;Universities;urinary;Waiting Lists;Woman;women's outcomes

PROJECT_TITLE: Treatment of Health Complications due to Female Genital Mutilation/Cutting in Tanzania: Curriculum Build, Implementation, and Evaluation

STUDY_SECTION: ICSC

STUDY_SECTION_NAME: Interdisciplinary Clinical Care in Specialty Care Settings Study Section[ICSC]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Nutrition;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: NEW YORK

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE Pregnancy ends in preterm birth (PTB) for approximately 1 in 10 women, though more often for Non-Hispanic Black women, with 14.12% PTB rate, compared to 9.09% for Non-Hispanic White women. Racial and ethnic differences have also been reported in dietary behaviors in response to stress and economic adversity such as food insecurity. In this project, we will identify nutritional profiles of pregnant women with food insecurity and psychosocial stress, determine racial and ethnic differences in nutritional profiles by food insecurity and psychosocial stress experiences, and evaluate whether nutritional profiles affect the pathway by which food- and psychosocial-related stress contributes to increased risk for PTB among racial and ethnic minoritized women.

PI_NAMEs: GYAMFI-BANNERMAN, CYNTHIA ;MONK, CATHERINE E (contact);PICARD, MARTIN ;TRUMPFF, CAROLINE

PROGRAM_OFFICER_NAME: ROUSSOS, GINA PATIENCE

PROJECT_TERMS: acute stress;Affect;Anxiety;Asthma;Attention deficit hyperactivity disorder;Behavior;Behavioral Mechanisms;Biological;Biological Markers;Birth;Birth Rate;Black race;black women;Cardiovascular Diseases;Chronic Kidney Failure;dietary;Dietary intake;Disparity;Economics;ethnic difference;ethnic disparity;Ethnic Minority Women;Ethnic Origin;experience;Food;food insecurity;Future;Gestational Age;Health;Hypertension;Infant;intergenerational;Intervention;Kidney Diseases;Life;Literature;Maternal Health;maternal stress;Mediating;Mediation;Mental Depression;Mothers;neonatal morbidity;Neonatal Mortality;Not Hispanic or Latino;Nutritional;Pathway interactions;Patient Self-Report;pediatric trauma;perceived stress;Physiological;Pregnancy;Pregnant Women;Premature Birth;Prenatal Nutrition;Psyche structure;psychosocial;Psychosocial Stress;Race;racial difference;racial disparity;racial minority women;Reporting;response;Risk;Sampling;Serum;Socioeconomic Status;Stress;Testing;United States;Vitamin D;Wheezing;White Women;Woman

PROJECT_TITLE: Determining the Effects of Food Insecurity and Psychosocial Stress on Racial and Ethnic Disparities in Prenatal Nutrition and Preterm Birth Risk


NIH_SPENDING_CATS: Asthma;Biotechnology;Lung

ORG_NAME: MAYO CLINIC ROCHESTER

PHR: PROJECT NARRATIVE Transmembrane protein 178 (Tmem178) mediates a novel endogenous inhibitory mechanism in asthma. This project will characterize the role of Tmem178 in bronchial epithelial cells and asthma pathogenesis. Understanding the mechanism of Tmem178 action could lead to the development of novel strategies to inhibit lung inflammation and restore homeostasis in the asthmatic airway epithelial barrier.

PI_NAMEs: CHIARELLA, SERGIO E (contact)

PROGRAM_OFFICER_NAME: LU, JINING

PROJECT_TERMS: Adenosine Triphosphate;Adrenal Cortex Hormones;Affect;airway epithelium;airway hyperresponsiveness;Allergens;Asthma;asthma exacerbation;asthma model;asthmatic;asthmatic airway;asthmatic patient;bronchial epithelium;Calcium;Cell Culture Techniques;Cell Physiology;Cellular biology;Characteristics;Chronic;Clinical;Clinical Data;clinical phenotype;cohort;Collagen;Color;CRISPR/Cas technology;cytokine;Data;Deposition;Development;diverse data;Endoplasmic Reticulum;Epithelial Cells;Flow Cytometry;Gene Expression;Genetic;genome sequencing;Goals;Health;high risk;Histologic;Homeostasis;Hospitalization;Human;Image;Immunophenotyping;In Vitro;in vivo;Individual;Inflammation;Inflammatory;inflammatory lung disease;Integral Membrane Protein;Interleukins;live cell microscopy;Lung;Lung Diseases;Mediating;Methods;mouse model;Mus;novel;novel strategies;novel therapeutics;Outcome;Pathogenesis;Pathology;Pathway interactions;Patients;Persons;Phenotype;prevent;Production;programs;pulmonary function;Pulmonary Function Test/Forced Expiratory Volume 1;Pulmonary Inflammation;Research;Resolution;Respiratory Mechanics;response;Role;Severities;Severity of illness;Signal Transduction;Small Interfering RNA;STIM1 gene;temporal measurement;Testing;Tissues;transcriptome sequencing;Transfection;Variant;whole genome

PROJECT_TITLE: Transmembrane Protein 178 as a Novel Endogenous Inhibitory Mechanism in Asthma

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Immunotherapy;Orphan Drug;Pediatric;Primary Immunodeficiencies;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_NAME: NATIONAL MARROW DONOR PROGRAM

PHR: Narrative: The PTCTC is the largest pediatric-focused hematopoietic stem cell transplantation consortium in the world. In this proposal we describe our plans and desire to continue to be a core clinical consortium (CCC) of the BMT CTN. These include (A) Detailing our unique capabilities of the PTCTC within the BMT CTN; (B) Proposing a clinical trial to optimize the conditioning regimen for children and adults with Inborn Errors of Immunity (IEI); and (C) Describing the operational and scientific approach of the PTCTC to HCT trials, and how this approach could benefit the BMT CTN. The proposed research is highly relevant to public health because it aims to improve clinical outcomes for patients that are undergoing hematopoietic stem cell transplantation, for both malignant and non-malignant hematologic diseases.

PI_NAMEs: KEAN, LESLIE S;STEFANSKI, HEATHER E (contact);VERNERIS, MICHAEL R.

PROGRAM_OFFICER_NAME: DI FRONZO, NANCY L

PROJECT_TERMS: Address;Adult;Allogenic;Area;Australia;Body Surface Area;Canada;Cell Therapy;Cells;chemotherapy;Child;Childhood;chronic graft versus host disease;Clinical;Clinical Trials;conditioning;congenital immunodeficiency;Creativeness;Cyclophosphamide;Cytotoxic Chemotherapy;Dedications;design;Diagnostic tests;Discipline;Disease;Disease-Free Survival;DNA;Dose;Drug Exposure;Drug Kinetics;Early identification;Engraftment;Enrollment;Ensure;Equilibrium;Ethnic Origin;Exhibits;Genetic Diseases;genetically modified cells;Geography;graft failure;Hematological Disease;Hematopoietic Stem Cell Transplantation;Immune;Immune response;Immune system;Immunosuppression;improved;Individual;Infrastructure;innovation;Investigational Drugs;Leadership;Life;Malignant - descriptor;member;Mentorship;Metabolism;Modeling;New Zealand;next generation;Non-Malignant;Outcome;Patient-Focused Outcomes;Patients;pediatric patients;pharmacokinetic model;Population Heterogeneity;Positioning Attribute;post-transplant;Prior Chemotherapy;Procedures;Provider;Public Health;Race;Recovery;Regimen;Research;Research Personnel;Science;screening;secondary endpoint;Site;socioeconomics;Structure;Testing;Therapeutic;Toxic effect;transplant centers;Transplant Recipients;transplantation therapy;trial enrollment;Variant;Weight;Work;young adult

PROJECT_TITLE: BMT Core - Pediatric Transplantation and Cellular Therapy Consortium (PTCTC):  Providing Clinical Trial Access For Children With Life Threatening Diseases

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-L (M1)]


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Endocrine Disruptors;Pediatric;Women's Health Research

ORG_DEPT: VETERINARY SCIENCES

PHR: PROJECT NARRATIVE The proposed supplement will investigate the contribution of extrahepatic metabolism by human and mouse cytochrome P450 enzymes influences neurotoxic outcomes in experimental animals exposed to LC-PCBs in the maternal diet throughout gestation and lactation. These outcomes are relevant to public health because they will provide data critically needed to assess the risk these emerging environmental contaminants pose to the developing brain and provide insights regarding strategies for mitigating this risk in vulnerable human populations. Therefore, the proposed research is pertinent to the part of NIH’s mission that seeks to develop fundamental knowledge about living systems to enhance health and reduce the burden of human disease.

PI_NAMEs: LEHMLER, HANS-JOACHIM ;LEIN, PAMELA J (contact)

PROGRAM_OFFICER_NAME: LAWLER, CINDY P

PROJECT_TERMS: Address;Affect;Animal Experiments;Animals;axon growth;Brain;career;Child;CREB1 gene;CYP2B6 gene;Cytochrome P450;Data;Development;developmental neurotoxicity;dietary;Endocrine Glands;Endocrine system;Environmental Pollutants;Enzymes;Estradiol;estrogenic activity;Estrogens;Exposure to;Extrahepatic;Health;Hepatic;Hepatic Tissue;Homeostasis;Hormones;Human;human disease;Hydroxylation;In Vitro;in vivo;insight;Knockout Mice;Knowledge;Lactation;Link;liver metabolism;Lung;Mediating;Metabolism;Mission;Molecular;mother nutrition;mouse model;Mus;neurodevelopment;Neurodevelopmental Disorder;neurotoxic;novel;Organism;Outcome;Outcome Study;Ovary;oxidation;parent grant;Parents;pharmacologic;Polychlorinated Biphenyls;Population;Pregnancy;Pregnant Women;Process;Proteins;Public Health;Research;Risk;Risk Assessment;risk mitigation;Role;Serum;Signal Pathway;Testing;Tissues;United States National Institutes of Health

PROJECT_TITLE: Diversity Supplement to Molecular and Cellular Basis of PCB Developmental Neurotoxicity

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


NIH_SPENDING_CATS: Genetics;HIV/AIDS;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: SAN FRANCISCO

ORG_NAME: J. DAVID GLADSTONE INSTITUTES

PHR: PROJECT NARRATIVE Stochastic fluctuations in gene expression impact cell-fate specification decisions from embryogenesis to viral infection creating barriers for effective treatment interventions. Based on therapeutic precedents in neuroscience that use fluctuations to improve sensorimotor function, this project will identify centralized molecular and cellular mechanisms of noise modulation, that can be therapeutically targeted, in embryonic stem cells (ESCs). The proposed research will lead to development of new broad-spectrum noise modulators, and propel clinical translation of noise-modulating molecules to guide new therapeutic approaches that overcome barriers to precise cell-fate control in diverse mammalian systems.

PI_NAMEs: WEINBERGER, LEOR S (contact)

PROGRAM_OFFICER_NAME: LAWRENCE, DIANE M

PROJECT_TERMS: Address;Affect;Architecture;Attenuated;Award;Bacteria;biological systems;Cell Fate Control;cell fate specification;Cells;Cellular biology;Chemosensitization;circadian;Circadian Rhythms;Clinical;clinical translation;Cytoplasm;Data;Development;Disparate;drug repurposing;effective therapy;Electrophysiology (science);Embryonic Development;embryonic stem cell;Engineering;Enhancers;Evolution;FDA approved;Feedback;Flow Cytometry;Gene Expression;Genes;Genetic;Genetic Transcription;Goals;Heterogeneity;HIV;improved;in vivo;Intervention;knock-down;Knowledge;Literature;Malignant Neoplasms;Mammalian Cell;Maps;mathematical model;Modeling;Molecular;molecular modeling;mutant;Neurosciences;Noise;novel;novel therapeutic intervention;Nuclear Export;Outcome;Pathway interactions;pharmacologic;posttranscriptional;predictive modeling;reactivation from latency;Reporter;Research;Rest;Role;Safety;Science;Sensorimotor functions;Source;Specific qualifier value;Starvation;stem cells;Stress;synergism;System;T-Lymphocyte;Testing;Therapeutic;therapeutic development;Therapeutic Effect;therapeutic target;tool;Transcription Coactivator;transcriptome;Translations;Viral;Virus Diseases;Virus Latency;Work;Yeasts

PROJECT_TITLE: Modulating Stochastic Gene Expression for Cell-fate Control and Therapeutics

STUDY_SECTION: MABS

STUDY_SECTION_NAME: Modeling and Analysis of Biological Systems Study Section[MABS]