NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Digestive Diseases;Gene Therapy;Genetics;Nanotechnology;Orphan Drug;Pancreatic Cancer;Rare Diseases

ORG_CITY: TOLEDO

ORG_NAME: UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS

PHR: This project proposes novel, genetically engineered smart exosomes that will overcome obstacles currently preventing the effective use of nanodelivery technologies in cancer treatment. Our proposed studies aim to advance a safe, efficient, and stable nanodelivery system that actively targets pancreatic cancer (PDAC). The knowledge generated by this work will contribute to the development of an innovative smart exosome nanocarrier-based platform for applications ranging from diagnostic medicine to novel therapeutic strategies for treating cancers such as PDAC.

PI_NAMEs: LIU, SHI-HE  (contact)

PROGRAM_OFFICER_NAME: AVULA, LEELA RANI

PROJECT_TERMS: 3-Dimensional;Adjuvant Therapy;Binding;biomaterial compatibility;Cancer Biology;cancer cell;cancer therapy;CD47 gene;Cells;Cessation of life;chemotherapy;Circulation;clinically relevant;cytotoxic;Data;delivery vehicle;Development;Diagnostic;Disease;DNA;Drug Carriers;Drug Delivery Systems;Eating;efficacy evaluation;efficacy validation;engineered exosomes;Engineering;Epidermal Growth Factor Receptor;Exhibits;exosome;extracellular;extracellular vesicles;Future;Gene Delivery;Genetic Engineering;Genetically Engineered Mouse;Goals;Heterogeneity;Homing;Human;immunogenicity;improved;In Vitro;in vitro Model;in vivo;in vivo Model;innovation;Integrins;Knowledge;Lead;Lipids;Liposomes;Liver;macromolecule;Macrophage;Malignant neoplasm of pancreas;Malignant Neoplasms;Medicine;Metabolic Clearance Rate;Modeling;Mononuclear;mouse model;nanocarrier;Nanodelivery;nanoparticle;nanoscale;neoplastic cell;novel;novel therapeutic intervention;Operative Surgical Procedures;Outcome;overexpression;pancreas xenograft;pancreatic cancer cells;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;pancreatic PDX models;Patients;Penetration;Peptides;Phagocytes;Phagocytosis;Pharmaceutical Preparations;prevent;Property;Proteins;receptor binding;Regimen;Research;RNA;SHPS-1 protein;Signal Transduction;Site;small molecule;Solid;spheroids;Spleen;success;Surface;System;targeted cancer therapy;targeted treatment;Techniques;Technology;Testing;Therapeutic;Therapeutic Effect;translational potential;tumor;Tumor Escape;United States;uptake;Work

PROJECT_TITLE: Engineering Exosome for Pancreatic Cancer Targeting Therapies

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]


ADMINISTERING_IC: NR

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF NURSING

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Adolescent Sexual Activity;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Homelessness;Infectious Diseases;Mental Health;Pediatric;Prevention;Sexually Transmitted Infections;Social Determinants of Health

ORG_CITY: HOUSTON

ORG_COUNTRY: UNITED STATES

ORG_DEPT: MISCELLANEOUS

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: Youth experiencing homelessness (YEH) are at heightened risk for HIV and experience extreme challenges to accessing HIV prevention care, compounded by substance use and stress. The goal is to conduct a randomized trial of a promising digital intervention among YEH 18-25 to examine the HIV prevention impact.

PI_NAMEs: SANTA MARIA, DIANE M. (contact)

PROGRAM_OFFICER_NAME: GODETTE, DIONNE

PROJECT_TERMS: Accounting;adaptive intervention;Address;aged;AIDS prevention;Attention;attentional control;Behavioral;Caring;children of color;Communities;condoms;cost;Counseling;County;Data;design;Detection;digital health;digital intervention;Discrimination;Drug usage;Ecological momentary assessment;Eligibility Determination;emotion dysregulation;Epidemic;experience;Face;Feedback;Geography;Goals;Health;Health Care Costs;health care service utilization;health equity;Health Insurance;Health Services Accessibility;Health Technology;Healthcare;Heterosexuals;high risk;HIV;HIV disparities;HIV risk;Homelessness;Housing;housing instability;Hybrids;implementation trial;improved;individualized prevention;Infection;innovation;Intervention;Investments;Lead;Life Experience;marginalization;meetings;men;mental disorder diagnosis;Mental Health;Mental Health Services;mhealth interventions;mobile computing;mobile delivery;Modeling;Motivation;motivational enhancement therapy;Nurses;Personal Satisfaction;Pharmaceutical Preparations;Population;pre-exposure prophylaxis;Prevalence;prevent;Prevention;prevention service;Prevention strategy;preventive intervention;Prophylactic treatment;Randomized;randomized trial;Reporting;Risk;Risk Factors;screening;service delivery;Services;sex;sexual exploitation;Sexual Partners;shared decision making;skills;social determinants;social health determinants;social stigma;Stress;substance use;technology intervention;Testing;Time;time use;Transcend;transgender;Transportation;Unsafe Sex;uptake;Wait Time;willingness;young adult;young men who have sex with men;young woman;Youth

PROJECT_TITLE: Assessing the use of MY-RIDE, a just-in-time adaptive intervention, to Improve HIV prevention and Substance Use in Youth Experiencing Homelessness

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Breast Cancer;Cancer;Clinical Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Racial and Ethnic Minority Health Research;Social Determinants of Health;Telehealth;Women's Health Research

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: Project Narrative Disparities in breast cancer-related outcomes are pervasive and have been widely documented among racial and ethnic minorities, especially Black women. Substantial evidence demonstrates that routine patient-reported outcome (PRO) data collection using health information technology (HIT) results in improved cancer care delivery; however, PRO reporting remains low among Black patients and within the community cancer care (CCC) settings where they often receive care, and this increases disparities. The objectives of this project, in partnership with the Association of Community Cancer Centers, are to use implementation science and health equity frameworks to develop and implement routine HIT-assisted collection of PRO data at CCCs serving a high proportion of Black patients with breast cancer to produce and disseminate generalizable knowledge that can be used to unlock the benefits of PRO reporting to historically underserved patients and advance equitable cancer care and hence, is directly relevant to public health.

PI_NAMEs: EDELEN, MARIA ORLANDO;PUSIC, ANDREA LOUISE (contact)

PROGRAM_OFFICER_NAME: JENSEN, ROXANNE ELAINE

PROJECT_TERMS: Address;Advocate;Association of Community Cancer Centers;Baltimore;Baptist Church;Benchmarking;black patient;Black race;black women;Boston;Breast Cancer Patient;Cancer Biology;cancer care;Cancer Center;Cancer Patient;care delivery;Caring;clinical care;clinical practice;Collection;Communities;community organizations;community setting;Continuity of Patient Care;Data;Data Collection;Diagnosis;Disparity;disparity reduction;Equity;ethnic minority;Evaluation;experience;Failure;Feedback;flexibility;Fostering;Future;Geography;Goals;Health;health care disparity;Health Disparities Research;health equity;health information technology;health outcome disparity;Healthcare;Healthcare Systems;Hospitals;implementation outcomes;implementation science;improved;improved outcome;inattention;innovation;Institutional Racism;Intervention;Knowledge;Malignant Breast Neoplasm;Malignant Neoplasms;Maryland;Medical center;member;Methodist Church;Methods;Modeling;mortality;multidisciplinary;National Institute on Minority Health and Health Disparities;Neighborhood Health Center;Oncology;Outcome;Outcome Measure;patient engagement;Patient Outcomes Assessments;patient population;patient-clinician communication;Patients;Phase;Positioning Attribute;preference;Privacy;programs;Public Health;Quality of life;racial minority;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Reduce health disparities;Reporting;Research;Resources;response;Science;Structural Racism;success;symptom management;technology platform;Time;tool;Training;United States;Universities;Woman;Work

PROJECT_TITLE: Increasing Engagement in Patient Reported Outcome Measurement to Address Breast Cancer Care Disparities using Health Information Technology in Community Cancer Settings

STUDY_SECTION: ODHS

STUDY_SECTION_NAME: Organization and Delivery of Health Services Study Section[ODHS]


ED_INST_TYPE: SCHOOLS OF MEDICINE

NIH_SPENDING_CATS: Cancer;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Genetics;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hepatitis;Liver Cancer;Liver Disease;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases;Social Determinants of Health

ORG_CITY: CORAL GABLES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: Non-alcoholic fatty liver disease (NAFLD), commonly known as fatty liver, is a leading cause of liver cancer and disproportionately affects Latinos in the United States and worldwide. The proposed study will determine how genetic differences lead to increased risk of NAFLD and NAFLD-related complications, such as cirrhosis (scarring of the liver) and hepatocellular carcinoma, the most common form of liver cancer. Understanding how these genetic differences interact with environmental risk factors will allow us to (1) identify which individuals have the highest risk of developing liver cancer, (2) implement personalized treatment strategies aimed at reducing the risk of NAFLD-related complications, and (3) create personalized screening programs that target those individuals before cancer develops.

PI_NAMEs: FLORES, YVONNE NICOLE;JONES, PATRICIA DENISE (contact)

PROGRAM_OFFICER_NAME: MOMIN, BEHNOOSH RAMJI

PROJECT_TERMS: Affect;Aflatoxins;Alanine Transaminase;All of Us Research Program;Behavioral;Biological Markers;Black race;burden of illness;California;Candidate Disease Gene;Case/Control Studies;Characteristics;Chronic Hepatitis B;Cicatrix;Cirrhosis;Clinical;clinical risk;cohort;Collaborations;Community Health;Comprehensive Cancer Center;Country;Data;Detection;Diabetes Mellitus;Diet;disease phenotype;disease prognosis;disorder risk;Disparate;Disparity;Enrollment;Ensure;Environmental Risk Factor;Epidemiology;epidemiology study;Ethnic Population;Fatty Liver;gene environment interaction;Genetic;genetic association;Genetic Polymorphism;Genetic Risk;Genetic study;genome wide association study;Goals;Hepatic;Hepatitis C;high risk;HIV;improved;Incidence;Indigenous American;Individual;Institution;Insulin Resistance;Latino;Latino Population;Lead;Liver;Liver Cirrhosis;Liver Fibrosis;liver transplantation;Los Angeles;Malignant neoplasm of liver;Malignant Neoplasms;Medical;member;Metabolic syndrome;Mexico;modifiable risk;Neighborhoods;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;novel;Nucleotides;Obesity Epidemic;Participant;participant enrollment;Patient Recruitments;Patients;personalized approach;personalized medicine;personalized screening;Persons;phenome;polygenic risk score;population based;Poverty;precision medicine;Prevalence;Primary carcinoma of the liver cells;Principal Investigator;Progressive Disease;prospective;Prospective cohort;Puerto Rico;Race;racial diversity;racial population;recruit;Research;Research Personnel;Resources;Risk;Risk Factors;risk prediction model;Risk Reduction;risk stratification;Sampling;screening program;Severities;simple steatosis;Single Nucleotide Polymorphism;Site;social;social culture;STAT4 gene;Steatohepatitis;treatment strategy;United States;United States National Institutes of Health;Universities;Vulnerable Populations;Work

PROJECT_TITLE: Genetic and Environmental risk of NAFLD-related HCC In All Latinos: the GENIAL Study


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: Canton

ORG_NAME: HARVARD PILGRIM HEALTH CARE, INC.

PHR: PROJECT NARRATIVE Temporary, pandemic-related emergency allotments for the Supplemental Nutrition Assistance Program (SNAP) ended universally in March 2023, leading to a major decline in benefits for participants. This policy could have a large impact on participating households’ food purchase quality, especially for historically underserved populations with worse food access and pre-pandemic inequities in nutrition-related chronic disease. This project will evaluate the effects of the expiration of SNAP emergency allotments on the healthfulness of participant food purchases, identify potential inequities in these effects by rurality, race/ethnicity, and economic stability, and explore how concurrent economic, social, community, and retail factors influenced food choice after this policy change.

PI_NAMEs: PETIMAR, JOSHUA  (contact)

PROGRAM_OFFICER_NAME: HUSS, KAREN

PROJECT_TERMS: Affect;Black race;Characteristics;Chronic Disease;cohort;Communities;cooking;coping;COVID-19 pandemic;Data;economic disparity;Economics;Emergency Situation;Employment;Enrollment;Ensure;Ethnic Origin;experience;expiration;Food;Food Access;Food Preferences;food security;Future;good diet;Health;health disparity;health disparity populations;Health Food;Hispanic;Household;indexing;Individual;Inequity;interest;Interruption;Intervention;Interview;large datasets;Link;longitudinal analysis;Low income;Low Income Population;Measures;Methods;Natural experiment;Not Hispanic or Latino;nutrition;Nutritional;pandemic disease;Participant;Pattern;Persons;Policies;Policy Maker;Population;Poverty;pre-pandemic;Price;Process;programs;Quasi-experiment;Race;Research;Research Design;response;Rural;rural residence;rurality;Sales;Series;social;Source;Stress;Structure;study population;Supermarket;supply chain;Surveys;System;Time;underserved community;Underserved Population;Unemployment

PROJECT_TITLE: Impact of the expiration of temporary pandemic SNAP benefits on the healthfulness of supermarket food purchases


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Orphan Drug;Rare Diseases;Tuberculosis

ORG_CITY: MENANDS

ORG_NAME: WADSWORTH CENTER

ORG_STATE: NY

PHR: Project Narrative There is an urgent need for a shorter treatment regimen for tuberculosis (TB), an infectious disease caused by Mycobacterium tuberculosis (Mtb). To accomplish this challenge, it is necessary to understand the molecular principles underlying antibiotic tolerance in Mtb. In this proposal, we will investigate the significance of ribosome remodeling and hibernation in antibiotic tolerance of Mtb.

PI_NAMEs: AGRAWAL, RAJENDRA K;OJHA, ANIL KUMAR (contact)

PROGRAM_OFFICER_NAME: ROBINSON, RICHARD THOMAS

PROJECT_TERMS: Aminoglycoside resistance;Aminoglycosides;Animal Model;Antibiotic Resistance;antibiotic tolerance;Antibiotics;Bacterial Proteins;Binding;Binding Proteins;Biochemical;Cells;Cessation of life;Chronic;chronic infection;clinically relevant;Communicable Diseases;Complex;Drug resistance;Drug Targeting;Ensure;Environment;Family;Funding;Genetic;Genus Mycobacterium;Growth;Hibernation;Human;improved;in vivo;insight;Investigation;Kanamycin;Linezolid;Lung;Lung infections;member;Methods;Molecular;mouse model;Multidrug-Resistant Tuberculosis;Mus;mutant;mycobacterial;Mycobacterium smegmatis;Mycobacterium tuberculosis;novel;Nutrient;paralogous gene;Pathway interactions;Pharmaceutical Preparations;Physiological;Proteins;Public Health;recruit;Regimen;Reporting;Resistance;resistance mechanism;response;Resuscitation;Ribosomal Proteins;Ribosomes;Starvation;Streptomycin;Structure;Testing;Therapeutic;Treatment Protocols;Tuberculosis;tuberculosis treatment;Visualization;Y protein;Zinc

PROJECT_TITLE: Alternative Ribosomes & Antibiotic Tolerance in Mycobacteria

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AIRT-J(01)]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Brain Cancer;Brain Disorders;Cancer;Gene Therapy;Genetics;Immunotherapy;Neurosciences;Rare Diseases

ORG_CITY: SAN FRANCISCO

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE: This proposal describes a new T cell-based imaging strategy, namely, SNIPR-PET to directly visualize molecular markers of disease with great sensitivity and precision. Additionally, this proposal seeks to leverage the same technology to visualize the on-target and off-target activation of therapeutic T cells, enabling monitoring of treatment effectiveness and ensuring patient safety.

PI_NAMEs: ROYBAL, KOLE T (contact);WILSON, DAVID M

PROGRAM_OFFICER_NAME: LIN, CHARLES

PROJECT_TERMS: Address;Antibodies;Antigen Targeting;antigen-specific T cells;Antigens;Binding;Biological Monitoring;biomedical imaging;blood-brain barrier disruption;brain tissue;Cancer Detection;cancer therapy;CAR T cell therapy;CD8B1 gene;Cell Nucleus;Cells;Cessation of life;chimeric antigen receptor;chimeric antigen receptor T cells;Clinical Trials;Companions;cytokine;cytotoxicity;detection limit;Disease Marker;engineered T cells;Engineering;Ensure;epidermal growth factor receptor VIII;experimental study;Extracellular Domain;Focused Ultrasound;Genomics;Glioblastoma;Glioma;Goals;Growth Factor;Health;Histologic;Human;human disease;Image;imaging approach;imaging biomarker;imaging modality;imaging platform;Imaging technology;Immune;Immune response;Immunology;improved;In Vitro;in vivo;innovation;interdisciplinary collaboration;Interleukins;Intervention;leukemia/lymphoma;Malignant Neoplasms;Medical;Methods;migration;Modeling;Modern Medicine;Molecular;Molecular Biology;molecular imaging;molecular marker;Monitor;Monoclonal Antibodies;Mus;neoplastic cell;neurosurgery;non-invasive monitor;novel;Operative Surgical Procedures;overexpression;patient safety;Patients;Penetration;Performance;Pharmaceutical Preparations;Positioning Attribute;Positron-Emission Tomography;potential biomarker;pre-clinical;Proteins;Proteolysis;radiologist;Radiology Specialty;receptor;Reporter;Reporter Genes;Resistance;response;Safety;Screening for cancer;Sensitivity and Specificity;Shapes;Signal Transduction;Solid Neoplasm;Specificity;synthetic biology;System;T cell therapy;T-Cell Receptor;T-Lymphocyte;targeted treatment;Technology;Therapeutic;Thymidine Kinase;tomography;tool;transcription factor;Treatment Effectiveness;Treatment Efficacy;tumor;Visualization;Work;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Engineered T cell-based imaging for glioblastoma and CAR-T cell tracking

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ISB-C(03)M]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Chronic Pain;Clinical Research;Digestive Diseases;Neurosciences;Pain Research;Precision Medicine;Transplantation

ORG_CITY: MINNEAPOLIS

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE In chronic pancreatitis (CP), inflammation and fibrosis of the pancreas lead to significant pain and disability for many affected patients. In the most severely affected patients with CP, the complete removal of the pancreas called total pancreatectomy with islet autotransplantation (“TPIAT”) may be considered but does not always lead to significant pain relief. We will use data and specimens already collected from a rigorous, well-phenotyped, multicenter cohort of TPIAT patients to develop plasma and urine biomarkers that may predict responsiveness (e.g. pain relief) to TPIAT.

PI_NAMEs: BELLIN, MELENA D. (contact);STEEN, HANNO

PROGRAM_OFFICER_NAME: ANDERSEN, DANA K

PROJECT_TERMS: Abdominal Pain;acute pancreatitis;Affect;Autologous Transplantation;Back;biobank;Biological Markers;biomarker discovery;biomarker identification;biomarker validation;Blood;Blood specimen;candidate identification;Central Nervous System;central sensitization;Child;Chronic;chronic pain;chronic pancreatitis;Climacteric;Clinical;clinical center;cohort;Complex;Consent;Conventional Surgery;Cross-Sectional Studies;daily functioning;Data;Databases;design;disability;Disabling condition;Disease;disease phenotype;Duct (organ) structure;Enrollment;Excision;Fibrosis;follow-up;Funding;Genetic;Health;Healthcare;IL6ST gene;Immunoassay;Impairment;improved;Inflammation;Infrastructure;Infusion procedures;Insulin;intervention cost;Investigation;islet;Lead;Liver;Measures;Medical;Multicenter Studies;National Institute of Diabetes and Digestive and Kidney Diseases;Nociception;Observational Study;Operative Surgical Procedures;Opioid;opioid use;Pain;Pain interference;Pain management;pain outcome;pain reduction;pain relief;pain score;pain symptom;painful neuropathy;Pancreas;Pancreatectomy;Pancreatitis;Participant;participant enrollment;Patient Outcomes Assessments;Patient Selection;Patients;Pattern;Peripheral;Persistent pain;Persons;Phenotype;Plasma;Population;predicting response;predictive marker;preservation;Procedures;Production;Prognostic Marker;prospective;protein biomarkers;Proteins;Proteomics;Quality of life;Recurrence;Reporting;Resected;Resolution;response;Sampling;Source;Specimen;Stimulus;Symptoms;Syndrome;Time;Tissues;TNF gene;Total Pancreatectomy;Transforming Growth Factor beta;United States National Institutes of Health;urinary;Urine;Validation;Visceral;Visit;Work;young adult

PROJECT_TITLE: Protein biomarkers to predict pain outcomes after total pancreatectomy with islet autotransplant


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Patient Safety;Pediatric;Physical Activity;Prevention

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: MoTrPAC Narrative While there are many important health benefits of physical activity, how exercise exerts its effects is not fully understood. A more comprehensive understanding of the molecular mechanisms underlying the responses to exercise would significantly impact public health. Continuation of the Molecular Transducers of Physical Activity Consortium (MoTrPAC) will achieve its objective of generating a comprehensive map of the molecular responses to acute exercise and exercise training with the long-range goal of elucidating the mechanisms by which exercise improves health.

PI_NAMEs: HOUMARD, JOSEPH A;KRAUS, WILLIAM E (contact)

PROGRAM_OFFICER_NAME: CARIFI, EMILY FORAN

PROJECT_TERMS: 17 year old;18 year old;Acute;Adipose tissue;Adult;Age;age group;Age Years;Ancillary Study;Animals;Attention;Award;Bioinformatics;Biological Process;Blood;California;Categories;Charge;Chemicals;Child;Childhood;Chronic;Clinical;clinical center;Clinical Protocols;Clinical Research;clinical research site;Clinical Trials Data Monitoring Committees;cohort;Collaborations;Collection;Communication;Communities;COVID-19;COVID-19 pandemic;Data;design;Development;Disease Outcome;disorder risk;endurance exercise;Enrollment;Ensure;ethnic minority;Exercise;exercise intervention;exercise training;falls;follow-up;Frequencies;Funding;Gender;Goals;Health;Health Benefit;Heterogeneity;Human;improved;Individual;innovation;insight;Institutional Review Boards;Intervention;Manuals;Manuscripts;Maps;Measurement;men;Minority Groups;Molecular;Multi-site clinical study;multiple omics;Muscle;novel;Observational Study;operation;pandemic disease;Participant;Pathway interactions;Pediatric cohort;Phase;Phenotype;phenotypic data;Physical activity;physical conditioning;Physiological;pre-clinical;Procedures;Protocols documentation;public database;Public Health;quality assurance;Race;racial minority;Randomized;Randomized, Controlled Trials;recruit;Recruitment Activity;Research;Research Personnel;Resistance;resistance exercise;Resources;response;Rest;sedentary;sex;Site;Suspensions;Testing;Time;Tissues;Training;Training Programs;Transducers;United States National Institutes of Health;Universities;Visit;Woman;working group;Youth

PROJECT_TITLE: Molecular Transducers of Physical Activity and Health: NC Consortium Clinical Site


ADMINISTERING_IC: AA

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences;Sleep Research;Substance Misuse

ORG_CITY: SAN DIEGO

ORG_NAME: CAMINO PHARMA, LLC

PHR: PROJECT NARRATIVE Alcohol use disorder (AUD) is a significant problem in the United States with limited treatment options to reduce alcohol dependence and relapse. Based on the localization and signal transduction mechanism of metabotropic glutamate 2 (mGlu2) receptors, there is a strong rationale that positive allosteric modulators (PAMs) of mGlu2 will effectively treat multiple symptoms that contribute to alcohol dependence and relapse, including attenuation of ethanol self-administration and sleep disturbances. The overarching goal of this application is to assess the potential of mGlu2 PAMs as a novel pharmacological treatment for AUD.

PI_NAMEs: GADIENT, RETO ANDREAS (contact);GOULD, ROBERT WARREN;SHEFFLER, DOUGLAS J

PROGRAM_OFFICER_NAME: FALK, DANIEL EVAN

PROJECT_TERMS: Abstinence;acamprosate;Acute;Adult;Adverse event;Affect;Agonist;Alcohol consumption;Alcohol dependence;alcohol effect;alcohol relapse;alcohol seeking behavior;alcohol use disorder;Alcohol withdrawal syndrome;alcoholism therapy;Alcohols;Amygdaloid structure;anxiety-related disorders;associated symptom;Attenuated;attenuation;Basal Ganglia;Behavior;binge drinking;Blinded;Brain region;Cause of Death;Cessation of life;Chronic;chronic alcohol ingestion;clinical development;Clinical Research;Corpus striatum structure;Coupled;Cues;Data;Development;Devices;Disulfiram;Dose;Double-Blind Method;Down-Regulation;drug action;Drug Kinetics;drug misuse;Drug usage;Economic Burden;effective therapy;effectiveness validation;Electroencephalography;Emergency Situation;Ethanol;Ethanol dependence;Exclusion;experience;Exposure to;Glutamates;Goals;GTP-Binding Proteins;Health;Hippocampus;Homeostasis;Human;Implant;in vivo;Intoxication;Investigational New Drug Application;Maximum Tolerated Dose;Medical;medical schools;Medicine;metabotropic glutamate receptor 2;Metabotropic Glutamate Receptors;Modeling;multidisciplinary;Mus;Naltrexone;negative emotional state;Neurons;Neurotransmitters;non-smoker;novel;novel drug class;novel therapeutic intervention;Outcome;Pathology;Patients;Pharmaceutical Preparations;Pharmacological Treatment;Phase;Placebo Control;Plasma;Play;positive allosteric modulator;pre-clinical;preclinical development;preclinical study;Prefrontal Cortex;presynaptic;Randomized;Rattus;Relapse;relapse prevention;Reporting;Research;Research Personnel;Rodent;Rodent Model;Self Administration;Serious Adverse Event;Severities;Signal Transduction;Sleep;Sleep disturbances;Sleep Fragmentations;small molecule;Smoker;smoking cessation;Societies;Stress;Substance Use Disorder;Surveys;Symptoms;System;Testing;Toxic effect;United States;United States Food and Drug Administration;Universities;Validation;vapor;Visit;wireless;Withdrawal

PROJECT_TITLE: Preclinical validation of mGlu2 PAMs in alcohol use disorder


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: PHILADELPHIA

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative PHLHousing+ -- a housing-focused guaranteed income experiment – provides a unique opportunity to test whether unconditional monthly cash payments reduce health disparities for minoritized groups who, historically, experience high rates of insecure and unhealthy housing. Data from randomized controlled trials of housing programs are sorely needed to evaluate effects on health outcomes and to inform efforts to translate temporary supports introduced during the pandemic into permanent ones. Study findings will have immediate implications for the City of Philadelphia's model for providing housing assistance, will inform efforts to establish similar programs in other cities, and will inform federal approaches to rental assistance.

PI_NAMEs: ABELLA, BENJAMIN S;JAFFEE, SARA R (contact);REINA, VINCENT J.

PROJECT_TERMS: 16 year old;Accident and Emergency department;Address;Adult;Affective;Age;anxiety symptoms;Area;authority;Behavior;Black race;Censuses;Child;Cities;Competence;Control Groups;COVID-19 pandemic;Crime;Data;depressive symptoms;Dimensions;Disease;Economics;Education;Effectiveness;Electronic Health Record;Eligibility Determination;Emergency department visit;Emergency Situation;Emotional;Evaluation;experience;experimental study;Exposure to;Family Sizes;Future;Goals;Health;health disparity;health equity;Health Promotion;Home;hospital utilization;Hospitalization;Hospitals;Household;Household Heads;Housing;Income;indexing;Injury;Link;Low income;Marketing;Measures;Medical;Mental Health;Minority Groups;minority health disparity;Modeling;Molds;Moods;Neighborhoods;Neurodevelopmental Problem;novel;Outcome;pandemic disease;participant retention;Pathway interactions;Patient Self-Report;payment;Pennsylvania;perceived stress;Philadelphia;physical conditioning;Police;Policies;Positioning Attribute;Problem behavior;programs;Property;Psyche structure;Random Allocation;Randomized;Randomized, Controlled Trials;Reduce health disparities;reduce symptoms;Respondent;Risk;Role;Sampling;Section 8;Secure;Security;social health determinants;socioeconomics;Surveys;Testing;Time;Translating;Trauma;U.S. Department of Housing and Urban Development;voucher;Waiting Lists;Woman;World Health Organization

PROJECT_TITLE: Evaluating the impact of PHLHousing+ on reducing health disparities


NIH_SPENDING_CATS: Breast Cancer;Cancer;Digestive Diseases;Pancreatic Cancer;Rare Diseases;Women's Health Research

ORG_DEPT: PHARMACOLOGY

PHR: My long-term goal is measuring how metabolism is altered in cancer so we can target cancer metabolism while sparing healthy tissues. Tumors are made up of a mix of cancer, immune, and connective tissue cells, which all play a role in supporting tumor growth, but the field has lacked approaches to measure metabolism in these different cell populations. I will use metabolic flux measurement techniques I have developed to measure the metabolism of each of the cell types living within the tumor, and to test whether targeting altered fluxes in cancer cells could slow tumor growth.

PI_NAMEs: BARTMAN, CAROLINE  (contact)

PROGRAM_OFFICER_NAME: WILLIS, KRISTINE AMALEE

PROJECT_TERMS: Address;Breast Cancer cell line;Breast Cancer Model;Burn injury;cancer cell;cancer therapy;Carbohydrates;CD8-Positive T-Lymphocytes;Cell Separation;cell type;Cells;chemotherapy;Citric Acid Cycle;Connective Tissue Cells;Consumption;Dichloroacetate;Diet;drug metabolism;Energy Metabolism;experimental study;Fatty acid glycerol esters;feeding;Fellowship;Fibroblasts;fighting;Genetic;genetically modified cells;Glycolysis;Goals;Growth;Immune;immune checkpoint blockade;Immune response;In Vitro;in vivo;Infiltration;Infusion procedures;Isotope Labeling;ketogenic diet;kinase inhibitor;Kinetics;Knock-out;Knowledge;Lung;Malignant neoplasm of pancreas;Malignant Neoplasms;Mammary Neoplasms;Measurement;Measures;Melanoma;Metabolic;Metabolism;Methods;Modeling;Monitor;Mus;Myeloid Cells;NADH;Neoplasm Metastasis;neoplastic cell;Normal tissue morphology;Nutrient;overexpression;oxidative damage;Oxidative Phosphorylation;Pancreatic Adenocarcinoma;Pathway interactions;PDH kinase;pharmacologic;Phase;Play;Population;Postdoctoral Fellow;Primary Neoplasm;Production;Productivity;Proteins;pyruvate dehydrogenase;restraint;Role;Sorting;stressor;Supporting Cell;synergism;System;Techniques;Testing;Therapeutic;Tissues;Tracer;tumor;tumor growth;tumor metabolism;tumor microenvironment;Up-Regulation

PROJECT_TITLE: Measuring and manipulating metabolic fluxes in the tumor microenvironment

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Transition to Independence Study Section (I)[NCI-I]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: PROJECT NARRATIVE The composition of cells in tissues evolves over time as changes to DNA alter a cell’s ability to adapt, expand, or die— a process called somatic evolution. Here, the proposed research will develop new genomics approaches to study somatic evolution in human tissues at single-cell resolution. As somatic evolution plays an important role in the predisposition to many diseases, including cancer, the successful completion of this research will reveal basic biological insights that may enable earlier detection of disease and unlock new opportunities for therapeutic intervention.

PI_NAMEs: LAREAU, CALEB ANDREW (contact)

PROGRAM_OFFICER_NAME: FUFA, TEMESGEN D

PROJECT_TERMS: Address;Adult;age-related disease;analytical tool;Antigens;Area;assay development;ATAC-seq;Bioinformatics;Biological;Biological Assay;biomarker identification;cancer cell;Cancerous;career;career development;Cell Differentiation process;Cell Ontogeny;Cell Physiology;cell type;Cells;Chromatin;Clonal Evolution;Clonal Expansion;Clonality;combinatorial;Complex;Computer Analysis;Constitution;cost;Cues;Data;Development;Disease;DNA;Doctor of Philosophy;early detection biomarkers;Early Diagnosis;Endometrial Neoplasms;Environment;Epigenetic Process;Evolution;Faculty;Funding;Future;Generations;genome sequencing;genome-wide;Genomic approach;Genomics;Goals;Growth;Gynecologic;Hematopoietic;Human;Human body;human genomics;human tissue;Immune;Immune system;Immunology;improved;indexing;Innate Immune System;innovation;insight;Libraries;Link;Macrophage;Malignant Neoplasms;Measurement;Measures;medical schools;Membrane Proteins;Mentors;method development;Methodology;Methods;Mitochondrial DNA;mitochondrial DNA mutation;Modality;Molecular;Molecular Profiling;multimodality;Multiomic Data;multiple omics;Mutation;National Human Genome Research Institute;new technology;novel;Nuclear;ovarian neoplasm;Pathogenesis;Pathology;patient stratification;Phase;Phenotype;Physiology;Play;Ploidies;Population;Positioning Attribute;post-doctoral training;Postdoctoral Fellow;Predisposition;premalignant;Preparation;Prevalence;Process;Program Development;Property;Proteins;Protocols documentation;Reaction;Records;Regulation;Research;Research Design;Research Infrastructure;Research Personnel;Resolution;Resources;response;RNA;Role;single cell genomics;single cell sequencing;single-cell RNA sequencing;skill acquisition;skills;Software Tools;Somatic Mutation;Specific qualifier value;Technical Expertise;Technology;technology development;tenure track;Therapeutic Intervention;Time;Tissues;tool;Training;Training Programs;transcriptome;Transposase;tumor;Universities;Vertebral column;whole genome;Work;XCL1 gene;Yolk Sac

PROJECT_TITLE: Charting somatic evolution via single-cell multiomics

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Adolescent Sexual Activity;Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Drug Abuse (NIDA only);Emergency Care;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Mental Illness;Opioid Misuse and Addiction;Opioids;Pediatric;Physical Injury - Accidents and Adverse Effects;Post-Traumatic Stress Disorder (PTSD);Prevention;Social Determinants of Health;Substance Misuse;Violence Against Women;Violence Research;Women's Health Research

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Project Narrative Sexual violence is a significant public health problem associated with elevated risk for posttraumatic stress disorder (PTSD) and opioid misuse and disorder; however, few, if any, early interventions to address PTSD and opioid use exist. The emergency department (ED) may represent an important, and in some cases, the only contact with medical care systems where early interventions can be implemented. In response to NOSI DA-23-007, HEAL Initiative: Opioid Use Disorder Care Pathways for Individuals with Histories of Exposure to Violence, this R61/R33 proposal seeks to develop and test a brief video and text messaging intervention to deliver in the ED to prevent the onset or escalation of posttraumatic stress disorder (PTSD) and opioid misuse and disorder among survivors of sexual assault.

PI_NAMEs: WALSH, KATIE L (contact)

PROGRAM_OFFICER_NAME: MITCHELL, SHANNON GWIN

PROJECT_TERMS: Accident and Emergency department;active control;Acute;acute stress;acute traumatic stress disorder;adaptive intervention;Address;Alcohol consumption;assault;care systems;Caring;chronic pain;Clip;community advisory board;comorbidity;coping;cost;Data;Disease;Distress;Early Intervention;Elements;Emergency department visit;empowerment;evidence base;experience;Feedback;Forcible intercourse;Forensic Medicine;Health;Helping to End Addiction Long-term;Individual;Intervention;marijuana use;Medical;meetings;memory encoding;Memory impairment;men;Mental Depression;Mental Health;mindfulness;nicotine use;novel;Opiate Addiction;Opioid;opioid epidemic;opioid misuse;opioid mortality;opioid use;opioid use disorder;Outcome;Participant;Pathway interactions;Personal Satisfaction;pilot test;Post-Traumatic Stress Disorders;prescription opioid;prescription opioid misuse;prevent;Prevention;programs;Public Health;Randomized;Randomized, Controlled Trials;Recording of previous events;Recovery;recruit;reduce symptoms;Reporting;Research;response;Risk;Sampling;Sequential Multiple Assignment Randomized Trial;sexual assault;sexual violence;Site;skills;skills training;Stress;Subgroup;substance misuse;suicidal;Survivors;Testing;Text Messaging;text messaging intervention;Time;tool;Training and Education;treatment as usual;trial comparing;trial design;United States;United States National Institutes of Health;usability;violence exposure;Woman

PROJECT_TITLE: "Testing a Video and Text Messaging Intervention to reduce PTSD and Opioid Misuse Among Sexual Violence Survivors"


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Arthritis;Behavioral and Social Science;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Complementary and Integrative Health;Mental Health;Neurosciences;Osteoarthritis;Pain Research;Physical Activity;Physical Rehabilitation;Prevention;Rehabilitation;Sleep Research

ORG_CITY: ANN ARBOR

ORG_DEPT: PHYSICAL MEDICINE & REHAB

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project narrative Although research has suggested that the modest and variable effects of exercise for knee osteoarthritis (KOA) pain may be partially explained by the presence of sleep disturbances, KOA exercise programs are yet to incorporate evidence-based components to improve sleep. This clinical trial will provide critical evidence on the benefit of a hybrid intervention for KOA pain management that incorporates an evidence-based sleep improvement component alongside a personalized exercise program and will identify characteristics of patients who benefit most from this approach. Granular, longitudinal psychosocial data will also be collected to describe mechanisms underlying intervention effects to guide future research into mechanisms underlying the sleep- physical activity-pain triad.

PI_NAMEs: WHIBLEY, DANIEL  (contact)

PROGRAM_OFFICER_NAME: RICE, ELISE

PROJECT_TERMS: Accelerometer;acceptability and feasibility;Address;Adherence;Adoption;Adult;Affect;Age;Algorithms;anxiety symptoms;arm;Awareness;behavior change;Behavior Therapy;Behavioral;biopsychosocial;central pain;Characteristics;chronic pain;Clinical;Clinical Practice Guideline;Clinical Trials;Cognitive;Cognitive Therapy;compare effectiveness;Data;Degenerative polyarthritis;depressive symptoms;digital;digital delivery;Disease;Ecological momentary assessment;economic impact;Education;Effectiveness;effectiveness evaluation;Effectiveness of Interventions;evidence base;Exercise;exercise program;experience;Fatigue;feasibility testing;Focus Groups;follow-up;Future;Goals;Guidelines;Health;human old age (65+);Hybrids;improved;improvement on sleep;Individual;Intervention;intervention effect;Knee Osteoarthritis;Link;Literature;Measures;Mediation;Mediator;Medicine;member;Meta-Analysis;Methods;multidisciplinary;negative affect;Observational Study;older adult;osteoarthritis pain;Pain;Pain intensity;Pain management;pain outcome;pain reduction;pain relief;Participant;Pathway interactions;Patient Outcomes Assessments;Patients;peripheral pain;Personal Satisfaction;Persons;Phenotype;Physical activity;Physical Exercise;Physical therapy;Population;precision medicine;Program Acceptability;programs;Psychological Factors;psychosocial;Publishing;Quality of life;Randomized;randomized trial;Recommendation;reduced muscle strength;remote delivery;Reporting;Research;Role;Severities;Sleep;Sleep disturbances;sleep health;Sleeplessness;Specific qualifier value;Strategic vision;Subgroup;Symptoms;Testing;United States National Institutes of Health;vigilance

PROJECT_TITLE: Move and Snooze: Adding insomnia treatment to an exercise program to improve pain outcomes in older adults with knee osteoarthritis

STUDY_SECTION: BMHO

STUDY_SECTION_NAME: Biobehavioral Medicine and Health Outcomes Study Section[BMHO]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Childhood Leukemia;Genetics;Hematology;Human Genome;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: DUARTE

ORG_NAME: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE

PHR: Project Narrative: Despite considerable improvement in treatment-adapted strategies, the five-year survival rate of acute myeloid leukemia (AML) patients, especially those with TET2 deficiency or suppression, is still lower than 30%, and thus there is an unmet medical need to identify new therapeutic target(s) and develop improved therapies. This proposal aims to determine the role of TET2 in leukemia stem/initiating cell homing, self-renewal, and bone marrow microenvironment, and delineate the molecular mechanism(s) by which TET2 loss in AML confers a more aggressive clinical prognosis. We will also develop novel effective approaches by combining CXCR4 inhibitors with hypomethylating agents and assess its therapeutic potential to cure high-risk AML patients with TET2 deficiency or suppression.

PI_NAMEs: CHEN, JIANJUN  (contact)

PROGRAM_OFFICER_NAME: SAYYED, ZULEKHA I

PROJECT_TERMS: Acute Myelocytic Leukemia;adverse outcome;Apical;Basic Science;Binding;Biological;Biological Assay;Biological Process;Biology;bisulfite sequencing;Bone Marrow;Bone Marrow Transplantation;Cells;Chemicals;chemokine receptor;Chemoresistance;clinical prognosis;Clonal Expansion;conventional therapy;Coupled;CXCR4 gene;Cytosine;Data;demethylation;Development;Dioxygenases;DNA;DNA binding protein B;DNMT3a;Drug resistance;Enzymes;epitranscriptomics;FLT3 gene;gain of function;Genetic Transcription;Hematopoietic Neoplasms;hematopoietic stem cell self-renewal;high risk;Homing;improved;In Vitro;in vivo;infancy;inhibitor;Investigation;Knock-in Mouse;Knockout Mice;Knowledge;leukemia;leukemogenesis;Ligands;loss of function;Maintenance;Mass Spectrum Analysis;Mediating;Medical;Messenger RNA;Methylation;migration;MLL-AF9;MLL-rearranged leukemia;Modeling;Modification;Molecular;mouse model;Mus;mutant;Mutate;Mutation;new therapeutic target;novel;NPM1 gene;Nucleotides;overexpression;oxidation;Pathway interactions;patient derived xenograft model;Patient-Focused Outcomes;Patients;pharmacologic;Play;Prognosis;programs;Regimen;Regulation;Relapse;Reporting;Resolution;RNA;RNA Stability;RNA-Binding Proteins;Role;RUNX1 gene;self-renewal;Signal Transduction;stem;Stromal Cell-Derived Factor 1;Survival Rate;Testing;Therapeutic;Transcript;transcriptome;transcriptome sequencing;Transfer RNA;Transgenic Organisms;translational medicine;Treatment Efficacy;tumor microenvironment;Validation

PROJECT_TITLE: TET2-mediated epitranscriptomic regulation in leukemia microenvironment

STUDY_SECTION: BCO

STUDY_SECTION_NAME: Biochemical and Cellular Oncogenesis Study Section[BCO]


ORG_CITY: CLEVELAND

ORG_DEPT: UROLOGY

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE Genetic mutations accumulate in every cell of our bodies throughout our lives, and these mutations have long been thought to be an important reason why our bodies age. However, it is not known whether some people accumulate mutations at a faster or slower rate with age, and whether differences in the rate at which mutations occur might predict how long we live and the risk for aging-related diseases. This study will answer these questions by measuring the mutation rate of a large number of people, which may allow us to predict, and understand why, people age differently.

PI_NAMEs: EVRONY, GILAD DAVID;SHOAG, JONATHAN  (contact)

PROGRAM_OFFICER_NAME: FU, YI-PING

PROJECT_TERMS: Age;Aging;aging biomarker;aging mechanism;aging process;aging related;aging related disease;Biological Aging;Blood;Blood specimen;Cancer Prevention Study II;Cells;Clinical;clinical biomarkers;cohort;Cytosine;Data;Deamination;disability;disorder risk;DNA Damage;DNA Sequence Alteration;DNA sequencing;Environmental Risk Factor;Epidemiology;epidemiology study;epigenetic aging;epigenetic clock;epigenetic marker;Epigenetic Process;epigenome;Foundations;Future;Genetic;Genome;Genomics;Germ-Line Mutation;Health;health data;healthy aging;Height;Hematopoiesis;Human;Human body;improved;Individual;Infrastructure;Intervention;Joints;life span;Life Style;lifestyle factors;Link;Longitudinal cohort;Longitudinal cohort study;Masks;Measurement;Measures;men;Methods;Methylation;methylation biomarker;molecular marker;mortality;mortality risk;Mutagens;Mutation;novel;novel marker;nutrition;Outcome;Pattern;Persons;Phenotype;Population;predictive marker;Prevalence;Preventive;Property;rate of aging;Research Design;Resources;Risk;Running;Sampling;Series;sex;Sex Differences;Somatic Mutation;Techniques;Technology;Testing;Time;Tissues;tool;United States;Weight;Woman;Women's Health

PROJECT_TITLE: Somatic mutation rates in healthy aging

STUDY_SECTION: AIMR

STUDY_SECTION_NAME:
Aging, Injury, Musculoskeletal, and Rheumatologic Disorders Study
Section[AIMR]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Biotechnology;Brain Disorders;Drug Abuse (NIDA only);Genetics;HIV/AIDS;Infectious Diseases;Methamphetamine;Neurodegenerative;Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: CHICAGO

ORG_NAME: RUSH UNIVERSITY MEDICAL CENTER

ORG_STATE: IL

PHR: PROJECT NARRATIVE A high percentage of people living with HIV/AIDS that do Methamphetamine abuse develop HIV associated neurocognitive disorders despite effective systemic antiretroviral therapy. The circumstances leading to persistent neuroinflammation, which play a part in neurocognitive disorders, are currently not defined. We will characterize mechanisms of HIV, and Methamphetamine-mediated DNA-damage detection in the brain that can trigger neuroinflammation, this knowledge can inform future therapies on NeuroHIV in the context of Methamphetamine.

PI_NAMEs: INACIO MAMEDE, JOAO FILIPE  (contact)

PROGRAM_OFFICER_NAME: TSAI, SHANG-YI ANNE

PROJECT_TERMS: abuse victim;Animal Model;antagonist;Anti-Retroviral Agents;Antigen-Antibody Complex;antiretroviral therapy;Astrocytes;Autopsy;Binding Proteins;Biological;Biological Assay;Biological Markers;Brain;brain cell;Capsid;Cell Culture Techniques;Cerebrum;Cessation of life;Chronic;Clinical;comorbidity;Complex;Consequences of HIV;CRISPR/Cas technology;Cyclic GMP;cytokine;Cytokine Signaling;Data;Dendritic Cells;Detection;Development;DNA Damage;Drug abuse;Event;Exhibits;experience;fluorescence imaging;Fluorescence Microscopy;Functional disorder;Future;Gene Activation;Gene Expression;Genetic Markers;Genomics;Heart;High Prevalence;HIV;HIV Infections;HIV Seronegativity;HIV therapy;HIV-1;HIV-associated neurocognitive disorder;HIV/AIDS;Homeostasis;Human;Image;Immunofluorescence Immunologic;Impaired cognition;improved;Individual;induced pluripotent stem cell;Inflammation;Inflammatory;innate immune sensing;Interferons;IRF3 gene;Knowledge;long term abstinence;Machine Learning;Measures;Mediating;Methamphetamine;methamphetamine abuse;methamphetamine effect;methamphetamine use;methamphetamine user;Microglia;microscopic imaging;Microscopy;Modeling;Modification;Molecular;Morbidity - disease rate;Mus;Myeloid Cell Activation;Natural Immunity;neuroAIDS;Neurocognitive Deficit;neurocognitive disorder;Neuroglia;neuroinflammation;Neurons;neurotropic;next generation sequencing;Organoids;Outcome Assessment;particle;pathogen;Pathogenicity;Pathway interactions;Pattern;Pattern recognition receptor;Periodicity;Persons;Pharmaceutical Preparations;Phase;Phenotype;Physiological;Play;polyglutamine;Process;Production;receptor;repaired;Research;Reverse Transcription;Role;Sampling;Signal Transduction;single-cell RNA sequencing;Stimulator of Interferon Genes;Substance abuse problem;targeted treatment;Techniques;Therapeutic;Time;ultra high resolution;Viral

PROJECT_TITLE: Molecular Pathways of Innate Immunity and Substance Abuse in NeuroHIV


ADMINISTERING_IC: MD

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: BALTIMORE

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative U.S. epidemiological data indicates that Black women are a high-risk HIV disparity group, yet initiation of novel prevention strategies like pre-exposure prophylaxis (PrEP) among this group is stagnant. Socio-structural challenges like intimate partner violence and gendered racism can constrain PrEP access among Black women, but few implementation studies have mitigated these challenges to improve PrEP initiation. The proposed research aims to implement and assess the effectiveness, implementation, and sustainability of a multilevel intervention to increase PrEP initiation among Black women with and without intimate partner violence in Baltimore.

PI_NAMEs: WILLIE, TIARA C. (contact)

PROGRAM_OFFICER_NAME: MUJURU, PRISCAH

PROJECT_TERMS: Address;Adoption;Affect;AIDS prevention;arm;Baltimore;Black race;black women;Caring;cis-female;Client;Clinic;Clinical;Collaborations;Community Healthcare;community setting;Consolidated Framework for Implementation Research;Data;Data Aggregation;design;Disparity population;Education;Educational Materials;Effectiveness;effectiveness evaluation;effectiveness testing;effectiveness/implementation study;Eligibility Determination;Environment;epidemic preparedness;epidemiologic data;Ethnic Population;Evaluation;experience;Exposure to;Face;Gender;Geography;health care availability;health disparity populations;Health system;Healthcare;Healthcare Systems;high risk;HIV;HIV disparities;HIV Infections;Hybrids;implementation evaluation;implementation outcomes;implementation strategy;implementation study;improved;Infection;innovation;insight;intersectionality;Intervention;intervention cost;Interview;intimate partner violence;Knowledge;Learning;Mediator;Medical;Mississippi;Modeling;Monitor;Neighborhood Health Center;novel;Outcome;patient-clinician communication;peer;peer support;Policies;post implementation;pre-exposure prophylaxis;prevent;Prevention strategy;Process;Protocols documentation;Provider;Public Health;Race;racial disparity;racial population;racism;Randomized;Research;Sampling;screening;Self Efficacy;Sexism;social structure;Social support;Stereotyping;structural determinants;Structure;Support Groups;Surveys;System;theories;therapy design;Training;Trauma;traumatic event;treatment arm;two-arm trial;uptake;Woman

PROJECT_TITLE: A Multi-Level Trauma-Informed Approach to Increase HIV Pre-exposure Prophylaxis Initiation among Black Women


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: CAMBRIDGE

ORG_NAME: IBIS REPRODUCTIVE HEALTH

PHR: PUBLIC HEALTH RELEVANCE/PROJECT NARRATIVE Population-level data on the sexual and reproductive health (SRH) needs and experiences of transgender, nonbinary, and intersex (TNBI) people in the U.S. are virtually non-existent. To further the cross-cutting goal identified by NICHD’s Strategic Plan 2020--of addressing health disparities for sexual and gender minorities-- this study will collect rigorous, foundational, epidemiological data on SRH risk factors and outcomes among a large, diverse sample of TNBI people from across the United States; data that are essential to designing effective public health interventions informing evidence-based healthcare, and improving health outcomes. Further, this study will test and evaluate innovations in study design and survey methodology that will improve recruitment, retention, and data quality in studies of marginalized populations across disciplines.

PI_NAMEs: MOSESON LIDOW, HEIDI SERENE (contact)

PROGRAM_OFFICER_NAME: POPKIN, RONNA

PROJECT_TERMS: abortion;Address;Adopted;adverse outcome;Anatomy;arm;Birth;Caring;cis-female;cisgender;clinical care;Color;Communities;Contraceptive Agents;Contraceptive Usage;Control Groups;cost;Data;Data Collection;Data Element;data quality;design;Discipline;Disparity;Dropout;Eligibility Determination;Enrollment;epidemiologic data;Equipment and supply inventories;evidence base;Exclusion;experience;Fertility;field survey;Funding;Gender;gender affirming care;Gender Identity;gender minority group;Geography;Goals;group intervention;Health;health care service;health data;health disparity;Health Personnel;Healthcare;HIV;improved;improved outcome;Incidence;innovation;Institute of Medicine (U.S.);Intersex;Knowledge;Language;Legal Abortion;LGBT Health;Logic;marginalized population;Measures;Medical;Methodology;Methods;National Institute of Child Health and Human Development;nonbinary;novel;Organ;Outcome;Participant;Patients;Persons;Policies;Population;Population Research;Pregnancy;Pregnancy Outcome;pregnant;prevent;primary outcome;Proliferating;Provider;public health intervention;public health relevance;public health research;Quality of Care;racial diversity;Randomized;randomized trial;Randomized, Controlled Trials;recruit;Reporting;Research;Research Design;Research Methodology;Research Personnel;research study;Research Support;Respondent;response;Risk;Risk Factors;Sampling;Sampling Studies;Scientific Advances and Accomplishments;screening;Screening procedure;sex;Sex Behavior;Sexual and Gender Minorities;sexual and reproductive health;Social Network;Strategic Planning;Survey Methodology;Surveys;Testing;tool;transgender;Underserved Population;unintended pregnancy;United States;United States National Institutes of Health;Universities;virtual;Woman;Youth

PROJECT_TITLE: Advancing novel survey tools to increase participation and improve sexual and reproductive health data quality

STUDY_SECTION: SSPB

STUDY_SECTION_NAME: Social Sciences and Population Studies B Study Section[SSPB]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Liver Cancer;Liver Disease;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Narrative The project is expected to yield actionable mechanistic insights into environmental exposures, tumor immunophenotype, and genetic factors driving the atypical presentation of HCC in Blacks and may identify new targets for intervention and prevention. The study will also yield a polygenic risk score for cirrhosis for use among ancestrally diverse populations. The results will alert patients and providers to the fact that HCC risk is disproportionate to cirrhosis stage in Blacks, raising awareness and encouraging early enrollment in surveillance.

PI_NAMEs: BRANCH, ANDREA D. (contact);STERLING, RICHARD K.

PROGRAM_OFFICER_NAME: READ-CONNOLE, ELIZABETH LEE

PROJECT_TERMS: Address;Architecture;Area;Aristolochic Acids;Automobile Driving;Awareness;biobank;Black American;black patient;Black Populations;Black race;Cancer Etiology;cancer initiation;cancer predisposition;cancer risk;Chronic Hepatitis C;Cirrhosis;Coal;cohort;Collaborations;Complex;Data;Diagnosis;digital;Disease Outcome;Disparity;DNA Damage;Enrollment;Environmental Exposure;Environmental Pollutants;Environmental Risk Factor;exome sequencing;experience;Exposure to;Frequencies;Genes;Genetic;Genetic Risk;Genomics;Heavy Metals;Hepatotoxicity;High Prevalence;Histologic;Human;Immunogenomics;Immunophenotyping;innovation;insight;Interferons;Intervention;Knowledge;Liver;Liver Cirrhosis;Liver diseases;liver injury;Low Prevalence;Malignant neoplasm of liver;Malignant Neoplasms;Maps;Minority Groups;Molecular;mortality;multidisciplinary;Mutagens;Mutate;Mutation;Nature;neoplastic cell;nonalcoholic steatohepatitis;Not Hispanic or Latino;novel;Oncogenic;Oncology;Participant;Pathway interactions;Patients;people of color;Phenotype;polygenic risk score;Population Heterogeneity;Prevalence;Prevention;Prevention strategy;Primary carcinoma of the liver cells;Production;Prostatic Neoplasms;Provider;Research Personnel;Resistance;Risk;Risk Factors;risk variant;Science;Single Nucleotide Polymorphism;Slide;Smoke;socioeconomics;Special Population;Specimen;Stains;Study Subject;Susceptibility Gene;synergism;The Cancer Genome Atlas;Time;tool;Toxin;transcriptomics;treatment strategy;tumor;tumor progression;tumorigenesis;underserved minority;Variant

PROJECT_TITLE: Genomic and environmental drivers of HCC in Non-Hispanic Blacks: Nature and nurture


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: UNIVERSITY PARK

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

PHR: Project Narrative The US foreign-born Latino population is rapidly aging and includes increasing numbers who, due to a lack of legal authorization, are excluded from the nation’s key social safety net programs for older adults. This project explores how immigrant legal status impacts the health and wellbeing of older (50+) Latinos, and the degree to which they can rely on kinship networks – chiefly their middle-aged children – for daily financial and health care needs.

PI_NAMEs: VAN HOOK, JENNIFER  (contact)

PROGRAM_OFFICER_NAME: BANDIERA, FRANK

PROJECT_TERMS: Adult;Adult Children;Aging;aging in place;allostatic load;Alzheimer's Disease;American;Authorization documentation;caregiving;Characteristics;Child;Childhood;comparison group;Consultations;Data;demographics;Effectiveness;Evidence based intervention;Exclusion;experience;Exposure to;Family;Family member;Financial Hardship;Future;Geography;Goals;Growth;Health;Health and Retirement Study;health care availability;health care service utilization;Health Insurance;Health Policy;Health Promotion;Health Services Accessibility;Health Status;Healthcare;Immigrant;Immigrant community;Immigration;Impaired cognition;improved;Individual;Inequality;innovation;intergenerational;Kinship Networks;Latino;Latino Population;Legal;Legal Status;Link;Measures;Mediating;Medicare/Medicaid;Mental Depression;Mental Health;Methods;Mexican;middle age;Modeling;models and simulation;mortality risk;Natural experiment;older adult;Older Population;Outcome;Pathway interactions;Personal Satisfaction;Play;Policies;Population;population health;poverty reduction;programs;Public Health Applications Research;Puerto Rican;Research;Resources;Retirement;Return Migrations;Role;safety net;Sampling;Science;simulation;social;socioeconomics;Source;Surveys;System;Testing;Time;trend;Uncertainty;Uninsured;United States Social Security Administration

PROJECT_TITLE: Legal Status Exposure, Health, and Kinship Networks among Latino Immigrants

STUDY_SECTION: SSPA

STUDY_SECTION_NAME: Social Sciences and Population Studies A Study Section[SSPA]


NIH_SPENDING_CATS: Aging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Immunotherapy;Prevention;Prostate Cancer;Urologic Diseases

ORG_CITY: LOS ANGELES

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

PHR: PROJECT NARRATIVE The proposed study will test the hypothesis that intensive lowering of circulating cholesterol decreases prostate cancer progression by stimulating a long-term antitumor immune response. Key observations made in mouse models will be examined in a clinical trial in patients diagnosed with prostate cancer on active surveillance. Demonstration that cholesterol-lowering therapy shows activity to activate long-term anti-tumor immunity will have impact on future trial design for primary and secondary cancer prevention and for examining for cholesterol lowering strategies for other cancers where immune stimulation can improve outcomes.

PI_NAMEs: KIM, HYUNG L (contact);THOMPSON, PATRICIA ANN

PROGRAM_OFFICER_NAME: PARNES, HOWARD L

PROJECT_TERMS: adaptive immune response;Aftercare;Animal Model;Animals;anti-tumor immune response;antitumor effect;Apoptosis;Atherosclerosis;Biological;Biological Markers;Biopsy;Blood;Cancer cell line;Cancer Control;Cancer Patient;cancer type;Cardiac health;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Physiology;Cells;Cessation of life;Chemoprevention;Cholesterol;Clinical Research;Clinical Trials;Colon Carcinoma;Combined Modality Therapy;Data;Dendritic Cells;design;Diagnosis;Disease Progression;Drug Costs;Enrollment;epidemiology study;Erectile dysfunction;Experimental Models;Exposure to;ezetimibe;FRAP1 gene;Future;Genetic;Genetic study;Goals;Heat shock proteins;Hepatic;high risk men;High-Risk Cancer;Human;Immune;Immune response;Immune system;immunogenic cell death;immunogenicity;Immunologic Memory;Immunologic Stimulation;Immunologics;immunoregulation;improved outcome;In Vitro;in vivo;Incontinence;individual patient;Infiltration;Intervention;Knockout Mice;Low-Density Lipoproteins;Lymphocyte;Lymphocytic Infiltrate;Macrophage;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant Neoplasms;Measures;Memory;men;Meta-Analysis;Modeling;Monitor;mortality risk;mouse model;mTOR inhibition;mTOR Signaling Pathway;Multi-Institutional Clinical Trial;Mus;Neoplasm Metastasis;neutrophil;Newly Diagnosed;Operative Surgical Procedures;Outcome;Participant;Pathway interactions;patient response;patient subsets;Patients;Peripheral;Pharmaceutical Preparations;pharmacologic;Phase;phase change;Phase III Clinical Trials;Population;Population Study;Pre-Clinical Model;preclinical study;prevent;Prevention strategy;Primary Cancer Prevention;primary endpoint;Proliferating;prospective;Prostate;prostate biopsy;prostate cancer model;prostate cancer progression;prostate cancer risk;Prostatectomy;Radiation;rational design;Regulatory T-Lymphocyte;Reporting;Resources;response;Risk;Secondary Cancer Prevention;Secondary Prevention;Serum;Signal Transduction;Simvastatin;Solid;T memory cell;Testing;Tissues;trafficking;trial design;tumor;tumor growth;Tumor Immunity;tumor progression;Tumor Tissue

PROJECT_TITLE: Intensive cholesterol-lowering intervention and anti-tumor immunity modeled in prostate cancer

STUDY_SECTION: CPSS

STUDY_SECTION_NAME: Cancer Prevention Study Section[CPSS]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Maternal Health;Maternal Morbidity and Mortality;Palliative Care;Pediatric;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Policy solutions that center the needs, priorities, and assets of birthing people and communities are required to address the stark and longstanding social disparities in pregnancy-related deaths and disability in New York City (NYC) and elsewhere. Integrated supportive care models (ISC) that increase access to quality obstetric services and improve the social determinants of health hold significant promise but are lacking empirical evidence. Guided by our academic-governmental-community partnership, our mixed-methods project will provide critical, timely new information on the multi-level impacts and implementation of NYC’s Medicaid- supported doula programs to inform dissemination and sustainability of policy-relevant ISC interventions and improve maternal health and health equity for birthing people in the United States.

PI_NAMEs: DAW, JAMIE ROBERTA (contact);DORVAL-MOLLER, MADELEINE ;HALL, KELLI STIDHAM;WHITNEY, ALISON

PROGRAM_OFFICER_NAME: GIVENS-BRADLEY, SHANNON SHAREE

PROJECT_TERMS: access disparities;Address;Age;Birth;Black Populations;Black race;Cardiovascular system;Caring;Cities;Client;Clinical;Communities;community organizations;community partnership;comorbidity;cost;Data;Death Rate;design;disability;Ecosystem;Effectiveness;Equity;ethnic minority population;Ethnic Origin;Evaluation;evidence base;experience;Face;Focus Groups;Friends;Geography;Health;health care service utilization;health equity;health inequalities;Health Services;Health Services Accessibility;Health system;high risk;Hispanic;Hospitals;implicit bias;improved;Income;Individual;innovation;Intervention;Interview;Lead;Leadership;Link;Low income;Maternal Health;Maternal health equity;Maternal Mortality;Maternity Hospitals;Medicaid;Medicaid eligibility;member;Mental Health;Methods;Modeling;Neighborhoods;New York;New York City;novel;obstetric services;Outcome;patient oriented;Personal Satisfaction;Persons;Play;Policies;postpartum health;pregnancy related death;prenatal;Process;programs;Psyche structure;Quasi-experiment;Race;racial minority population;Research;Risk;Role;Services;severe maternal morbidity;Site;social;social determinants;social disparities;social health determinants;Social status;Social Work;Socioeconomic Status;stakeholder perspectives;Strategic Planning;structural health determinants;Structure;support network;Supportive care;Surveys;Testing;Training;Trauma;United States;United States National Institutes of Health;Universities

PROJECT_TITLE: Integrated Supportive Care Policies to Improve Maternal Health Equity: Evaluating the Multi-level Effects and Implementation of Doula Programs for Medicaid-Eligible Birthing People in New York City


NIH_SPENDING_CATS: Autoimmune Disease;Bioengineering;Biomedical Imaging;Brain Disorders;Multiple Sclerosis;Neurodegenerative;Neurosciences

ORG_CITY: SAINT LOUIS

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Although activated immune cells are key players in multiple sclerosis (MS), and glutamate dysregulation contributes to tissue degeneration, the crosstalk between immune response and glutamate dynamics is not well understood. This proposal will develop and validate new non-invasive positron emission tomography and magnetic resonance imaging approaches to improve detection of immune cells and glutamate dynamics in real time, thus providing unprecedented information about their interplay in MS. Findings from this work will validate clinically translatable neuroimaging tools to provide new ways of assessing therapy responses, understanding underlying mechanisms in MS, and potentially aid in the design of novel treatments.

PI_NAMEs: GUGLIELMETTI, CAROLINE  (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: adaptive immune response;Amides;Amyotrophic Lateral Sclerosis;Animals;Anti-Inflammatory Agents;Astrocytes;axon injury;Biochemical Reaction;Blood - brain barrier anatomy;Brain;Cancer Model;Carbon;career;Cells;Cellular Metabolic Process;Central Nervous System;Clinical;clinical translation;clinically relevant;cytokine;Demyelinations;design;Detection;Development;Diagnosis;Disease;disease model;Disease Progression;Ensure;Evaluation;Event;Excitatory Amino Acid Transporter 2;excitotoxicity;first-in-human;Functional disorder;Glutamate Metabolism Pathway;Glutamates;Goals;Human;Image;imaging agent;imaging approach;imaging biomarker;imaging modality;imaging study;Imaging Techniques;Immune;immune activation;immune imaging;Immune response;Immune system;Immune System Diseases;Immunologic Monitoring;Immunology;Immunology procedure;immunoregulation;Impairment;improved;In Situ;in situ imaging;in vivo;Inflammation;Inflammatory;Innate Immune Response;Innate Immune System;innovation;Investigation;Knowledge;Label;Lesion;Lesion by Stage;Link;Lymphoid Tissue;Macrophage;Magnetic Resonance Imaging;magnetic resonance spectroscopic imaging;Measures;Mentors;Metabolic;Methods;Modeling;molecular imaging;Monitor;mouse model;multimodality;Multiple Sclerosis;Multiple Sclerosis Lesions;neuroimaging;neuroimmunology;neuroinflammation;Neurologic;non-invasive imaging;novel;Pathogenesis;Pathologic;Peripheral Nervous System;Phase;Play;Positioning Attribute;Positron-Emission Tomography;pre-clinical;prevent;Process;Production;programs;progressive neurodegeneration;Pyruvate;radiotracer;real-time images;Reporting;Research;reuptake;Role;Scientist;serial imaging;skills;Specificity;Spinal Cord;success;T cell infiltration;T-Cell Activation;T-Lymphocyte;Techniques;Technology;Time;tissue degeneration;Tissues;tool;Tracer;Training;treatment response;tumor;Visualization;Work

PROJECT_TITLE: Real time imaging of immune cells and glutamate dynamics by PET and metabolic MRI


NIH_SPENDING_CATS: Cancer;Clinical Research;Digestive Diseases;Immunotherapy;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stomach Cancer

ORG_CITY: CAMDEN

ORG_NAME: CORIELL INSTITUTE FOR MEDICAL RESEARCH

ORG_STATE: NJ

PHR: Project Narrative Gastric adenocarcinoma patients with peritoneal carcinomatosis (PC) die miserably due to the lack effective treatments and poor understanding of molecular biology. By utilizing patient-derived PC cells and preclinical models, we will uncover the functional importance of YAP1 in mediating cancer stemness and PC and elucidate the mechanisms by which YAP1 mediated immunosuppression to develop novel therapeutic strategies of inhibiting YAP1 and TIM3/Gal-9. Upon completion of this study, we will have a strong rationale for a novel combination that could overcome the shortcomings we experience in the clinics today.

PI_NAMEs: SONG, SHUMEI  (contact)

PROGRAM_OFFICER_NAME: CARDONE, MARCO

PROJECT_TERMS: Address;Affect;Antibodies;Ascites;Binding;Carcinomatosis;CD3 Antigens;CD8-Positive T-Lymphocytes;Cell Culture Techniques;Cell model;cell type;Cells;Clinic;Clinical;Clinical Trials;Clone Cells;Coculture Techniques;Collaborations;Combined Modality Therapy;CRISPR/Cas technology;CTLA4 gene;Data;effective therapy;experience;Flow Cytometry;Galactose Binding Lectin;Gastric Adenocarcinoma;Genetic;Genetically Engineered Mouse;Growth;Health;Human Development;Immune;immune checkpoint;Immune response;Immunosuppression;Immunotherapy;Implant;In Vitro;in vitro activity;in vivo;in vivo Model;ineffective therapies;Infrastructure;innovation;Joints;Knock-out;Ligands;Macrophage;malignant ascites;Malignant Neoplasms;Mediating;Metastasis Suppression;Modeling;Molecular;Molecular Biology;mouse model;Mus;Mutation;Neoplasm Metastasis;neoplastic cell;novel;novel strategies;novel therapeutic intervention;novel therapeutics;Outcome;paracrine;Patients;Peripheral Blood Mononuclear Cell;Peritoneal;Pharmacologic Substance;Pre-Clinical Model;Primary Neoplasm;programmed cell death ligand 1;programmed cell death protein 1;Property;PTPRC gene;Quality of life;receptor;Regulatory T-Lymphocyte;Resistance;Role;Sampling;single-cell RNA sequencing;Sorting;Specimen;Stains;stem cells;stemness;Stromal Cells;T cell response;T-Lymphocyte;TACSTD1 gene;targeted treatment;Technology;Testing;trait;transcriptome sequencing;Transforming Growth Factor beta;Translating;tumor;tumor growth;Tumor Immunity;tumor initiation;tumor microenvironment;Tumor Promotion;Tumor Tissue;University of Texas M D Anderson Cancer Center;Validation

PROJECT_TITLE: Molecular dissecting and targeting YAP1 mediated cancer stemness and immune suppression in advanced gastric adenocarcinoma

STUDY_SECTION: CONC

STUDY_SECTION_NAME: Clinical Oncology Study Section[CONC]


FUNDING_MECHANISM: RESEARCH CENTERS

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;HIV/AIDS

ORG_CITY: HONOLULU

ORG_NAME: UNIVERSITY OF HAWAII AT MANOA

ORG_STATE: HI

PI_NAMEs: MOKUAU, NOREEN ;MOKUAU, NOREEN  (contact)

PROJECT_TITLE: The Role of gp120 on Cardiovascular Disease in People Living with HIV


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Hematology;Orphan Drug;Rare Diseases

ORG_NAME: SARYA, LLC

PHR: PROJECT NARRATIVE In this study, Sarya LLC (Sarya) will develop and commercialize a new specific positron emission tomography (PET) imaging agent 64Cu-LLP2A for diagnosis, staging, and treatment of the hematological cancer, multiple myeloma (MM). The development of this technology will fulfill an unmet need for molecularly targeted, sensitive and specific MM imaging agents that can accurately stage and restage MM, identify high-risk MM patients, guide personalized MM treatment, and evaluate clinical response to treatment.

PI_NAMEs: BEREZIN, MIKHAIL Y. (contact)

PROGRAM_OFFICER_NAME: ZHAO, MING

PROJECT_TERMS: Adverse effects;Amendment;Biological Markers;bone;bone imaging;Bone Marrow;Bone marrow biopsy;Cell Surface Proteins;Cells;Cessation of life;Clinical;clinical imaging;Clinical Trials;commercialization;cost effective;Data;Detection;Development;Diagnosis;Discipline of Nuclear Medicine;Disease;Disease remission;Dose;dosimetry;Female;first-in-human;fluorodeoxyglucose;fluorodeoxyglucose positron emission tomography;Goals;Hematologic Neoplasms;Hematopoietic Neoplasms;hexokinase;high risk;Human;human study;Image;imaging agent;imaging detection;Imaging technology;Immunocompetent;improved;in vivo;Individual;Inflammatory;Integrin alpha4beta1;Intravenous;Investigational Drugs;Investigational New Drug Application;Lesion;Lytic Metastatic Lesion;male;Maps;Microscopic;Modeling;Molecular;Molecular Target;Multiple Myeloma;multiple myeloma M Protein;Mus;No-Observed-Adverse-Effect Level;non-invasive imaging;novel therapeutics;Organ;Outcome;overexpression;Patients;Performance;personalized medicine;Persons;Phase;Phase II Clinical Trials;Phenotype;Positron-Emission Tomography;preclinical imaging;prospective;Publishing;quantitative imaging;Radiation Dose Unit;Radiopharmaceuticals;Recurrent disease;Reference Standards;Refractory Disease;Reporting;Safety;Scanning;Serum;Serum Markers;sex;Signal Transduction;Skeletal bone;Skeletal Survey;SLC2A1 gene;Small Business Technology Transfer Research;Specificity;Staging;standard of care;technological innovation;Technology;technology development;Time;Tissues;Toxic effect;Toxicity Tests;treatment response;tumor;Tumor Burden;United States Food and Drug Administration;Universities;uptake;volunteer;Washington

PROJECT_TITLE: Development and Commercialization of a New Molecularly Targeted Imaging Agent for Multiple Myeloma


NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Biodefense and Related Countermeasures;Clinical Research;Coronaviruses;Coronaviruses Diagnostics and Prognostics;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Vaccines;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Immunization;Infectious Diseases;Lung;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Vaccine Related

ORG_CITY: OKLAHOMA CITY

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PHR: Project Narrative American Indian/Alaska Native (AI/AN) populations were disproportionately affected by the COVID-19 pandemic compared to other racial/ethnic populations. We plan to analyze RADx-UP consortium data to evaluate the impact of the COVID-19 pandemic on AI/AN RADx-UP participants with chronic health conditions, changes in access to healthcare, and sociodemographic factors on COVID-19 testing and vaccination uptake. This study will allow for development of intervention strategies to improve COVID-19 testing and vaccination uptake in this underserved population.

PI_NAMEs: COMIFORD, ASHLEY ;JANITZ, AMANDA E (contact)

PROGRAM_OFFICER_NAME: DAGHER, RADA K

PROJECT_TERMS: Address;Alaska Native;Alaska Native population;American Indian Population;American Indians;Appointment;Area;Asthma;Cardiovascular Diseases;checkup examination;Cherokee Indian;Cherokee Nation;Choctaw;Chronic;Chronic Disease;chronic liver disease;Chronic lung disease;Clinical;Common Data Element;Communities;COVID-19 complications;COVID-19 impact;COVID-19 pandemic;COVID-19 pandemic effects;COVID-19 patient;COVID-19 risk;COVID-19 testing;COVID-19 vaccination;COVID-19 vaccine;Data;Data Collection;data harmonization;deprivation;Development;Diabetes Mellitus;disease diagnosis;effective intervention;Ensure;Ethnic Population;experience;Funding;Geography;Goals;Health;health care availability;health care service;health disparity;Health Sciences;Health Services Accessibility;Healthcare;High Prevalence;high risk population;Hospitals;implementation strategy;Improve Access;improved;Individual;Interruption;intersectionality;Intervention;Knowledge;Malignant Neoplasms;Native Americans;Obesity;Oklahoma;Outcome;pandemic disease;Participant;Preventive healthcare;Race;racial population;RADx Underserved Populations;Research;Research Personnel;residence;Resources;response;Rural;rurality;Screening for cancer;Services;Site;Smoking;Social Distance;sociodemographic factors;sociodemographics;testing uptake;therapy development;tribal community;Underserved Population;Universities;uptake;Vaccination;vaccine acceptance;Vaccines;viral transmission;Work

PROJECT_TITLE: Chronic health conditions and uptake of COVID-19 testing and vaccination among Native Americans in the RADx-UP Consortium


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Coronaviruses;Coronaviruses Diagnostics and Prognostics;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Vaccines;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Immunization;Infectious Diseases;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Vaccine Related

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE The Rapid Acceleration in Diagnostics for Underserved Population (RADx-UP) consortium recruited over 370,000 participants to generate data on COVID-19 testing, pandemic stress, and vaccination among underserved and vulnerable persons across the US. Our team of epidemiologists, and chronic disease, infectious disease, and health policy experts plans to use these data test the performance of public health resource allocation and infection surveillance tools. Our goal is to mitigate health disparities during the inevitable future pandemic.

PI_NAMEs: ANAND, SHUCHI  (contact);CHERTOW, GLENN MATTHEW;PARSONNET, JULIE

PROGRAM_OFFICER_NAME: BARKSDALE, CRYSTAL

PROJECT_TERMS: 2019-nCoV;Age;American;American Indians;Area;Black race;Censuses;Centers for Disease Control and Prevention (U.S.);Cessation of life;Chronic Disease;Classification;Clinical Trials;Communicable Diseases;Communities;Community Surveys;County;COVID-19 incidence;COVID-19 pandemic;COVID-19 stress;COVID-19 test;COVID-19 testing;COVID-19 vaccine;Data;data structure;Dialysis procedure;disability;Disease;Disease Outbreaks;Disparity population;Ebola;emerging virus;Employment;Epidemiologist;Ethnic Origin;Evaluation;evidence base;experience;Face;Food;Funding;Future;future pandemic;Goals;Health;health care availability;health disparity;Health Insurance;Health Policy;Health system;Hispanic;home test;Hospitalization;hospitalization rates;Household;Housing;Human;improved;improved outcome;Income;indexing;Infection;Influenza;Influenza A Virus, H1N1 Subtype;Infrastructure;Investments;Link;Literature;Location;medical vulnerability;Methods;Middle East Respiratory Syndrome;minority health;Monkeypox;mortality;Neighborhoods;Nephrology;new pandemic;operation;Outcome;pandemic disease;pandemic preparedness;pandemic stress;Participant;pathogen;Patients;Perception;Performance;performance tests;Persons;Phase;Population;population survey;Positive Test Result;Pragmatic clinical trial;predictive test;Prevalence;Public Health;public health emergency;Public Health Practice;Race;RADx Underserved Populations;recruit;Reduce health disparities;Resource Allocation;Resources;response;Sampling;screening;secondary analysis;Severe Acute Respiratory Syndrome;Severity of illness;sex;Site;social;social vulnerability;socioeconomics;Speed;Standardization;Stress;stressor;System;Test Result;Testing;testing access;testing uptake;Time;tool;Traction;Triage;Uncertainty;Underserved Population;United States National Institutes of Health;uptake;Vaccination;vaccine access;Vaccines;vulnerable community;Vulnerable Populations;wastewater surveillance;Work;ZIKA

PROJECT_TITLE: Pandemic preparedness for underserved persons in the US: Harnessing data from the RADx-UP consortium to assess public health tools for resource allocation


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Patient Safety;Pediatric;Physical Activity;Prevention

ORG_CITY: BATON ROUGE

ORG_NAME: LSU PENNINGTON BIOMEDICAL RESEARCH CTR

ORG_STATE: LA

PHR: MoTrPAC Narrative While there are many important health benefits of physical activity, how exercise exerts its effects is not fully understood. A more comprehensive understanding of the molecular mechanisms underlying the responses to exercise would significantly impact public health. Continuation of the Molecular Transducers of Physical Activity Consortium (MoTrPAC) will achieve its objective of generating a comprehensive map of the molecular responses to acute exercise and exercise training. with a long-range goal of elucidating the mechanisms by which exercise improves health.

PI_NAMEs: RAVUSSIN, ERIC  (contact)

PROGRAM_OFFICER_NAME: CARIFI, EMILY FORAN

PROJECT_TERMS: 17 year old;18 year old;Acute;Adipose tissue;Adult;Age;age group;Age Years;Ancillary Study;Animals;Attention;Award;Bioinformatics;Biological Process;Blood;California;Categories;Charge;Chemicals;Child;Childhood;Chronic;Clinical;clinical center;Clinical Protocols;Clinical Research;Clinical Trials Data Monitoring Committees;cohort;Collaborations;Collection;Communication;Communities;COVID-19;COVID-19 pandemic;Data;design;Development;Disease;Disease Outcome;endurance exercise;Enrollment;Ensure;ethnic minority;Exercise;exercise intervention;exercise training;falls;follow-up;Frequencies;Funding;Gender;Goals;Health;Health Benefit;Heterogeneity;Human;improved;Individual;innovation;insight;Institutional Review Boards;Intervention;Manuals;Manuscripts;Maps;Measurement;men;Minority Groups;Molecular;Multi-site clinical study;multiple omics;Muscle;novel;Observational Study;operation;pandemic disease;Participant;Pathway interactions;Pediatric cohort;Phase;Phenotype;phenotypic data;Physical activity;Physiological;pre-clinical;Procedures;Protocols documentation;public database;Public Health;quality assurance;Race;racial minority;Randomized;Randomized, Controlled Trials;recruit;Recruitment Activity;Research;Research Personnel;Resistance;resistance exercise;Resources;response;Rest;sedentary;sex;Site;Suspensions;Testing;Time;Tissues;Training;Training Programs;Transducers;United States National Institutes of Health;Universities;Visit;Woman;working group;Youth

PROJECT_TITLE: Pennington MoTrPAC Adults - Renewal


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: Project Narrative  This project will design and field a new wave of the Child Development Supplement in 2023, as part of the on-going Panel Study of Income Dynamics (PSID), collecting data on all children aged 0–17 years in PSID families through interviews with primary caregivers (typically one of the child’s parents) and with older children themselves (aged 8–17 years). These new data will support studies of health, development, and well-being in childhood; the effects of the Covid-19 pandemic; the relationship between children’s characteristics and con- temporaneous family decisionmaking and behavior; and the effects of childhood factors on subsequent social, demographic, economic, and health outcomes over the entire life course for these individuals as they are fol- lowed into the future as part of PSID.

PI_NAMEs: SASTRY, NARAYAN  (contact)

PROGRAM_OFFICER_NAME: CAPPS, RANDOLPH CHRISTOPHER

PROJECT_TERMS: Achievement;Address;Adult;African American;aged;Behavior;Black race;Characteristics;Charge;Child;Child Behavior;Child Development;Childhood;Cognitive;cohort;Collection;COVID-19;COVID-19 impact;COVID-19 pandemic effects;Data;data centers;Data Collection;Data Sources;Decision Making;design;Development;diaries;Documentation;Economics;Education;experience;Family;Family dynamics;Family member;follow-up;Funding;Future;Generations;genetic analysis;Genetic Markers;Goals;grandparent;Grant;Health;Health Status;high school;Household;human capital;Immigrant;Immigrant family;Individual;insight;interest;intergenerational;Interview;Life Cycle Stages;Link;Longitudinal Surveys;Mathematics;Measures;media use;member;Movement;Neighborhoods;next generation;Nursery Schools;offspring;Outcome;pandemic disease;panel study of income dynamics;Parents;Participant;Personal Satisfaction;Policies;Population;Positioning Attribute;primary caregiver;Process;prospective;Racial injustice;Reading;Research;Research Personnel;Resources;Respondent;saliva sample;Sampling;Schools;Scientist;skills;social;social capital;Social Change;social science research;Social Sciences;Social Well-Being;statistics;Technology;Time;transmission process;welfare

PROJECT_TITLE: Transition from Preschool through High School: Family, Schools & Neighborhoods


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Biotechnology;Cancer;Chronic Pain;Dental, Oral, and Craniofacial Disease;Hematology;Orphan Drug;Pain Research;Prevention;Radiation Oncology;Rare Diseases

ORG_CITY: AURORA

ORG_NAME: ALLANDER BIOTECHNOLOGIES, INC.

ORG_STATE: CO

PHR: Narrative Oral mucositis, a painful oral ulceration, is one of the most debilitating toxicities of cancer therapy. Our proprietary drug targets multiple processes of oral mucositis thus delivering a more effective oral mucositis treatment in cancer patients. Our proposed studies will allow us to obtain IND approval by the FDA to initiate the first-in- human clinical trial after completion of this grant, thus bring a new therapy to clinic. Meeting this unmet need will improve cancer patient outcomes and quality of life by enabling optimal RT regimens, reducing pain and preventing other sequelae.

PI_NAMEs: WANG, XIAO-JING ;YOUNG, CHRISTIAN  (contact)

PROGRAM_OFFICER_NAME: LOPEZ, ORLANDO

PROJECT_TERMS: Acceleration;Adverse effects;Animals;antagonist;Antibodies;Autopsy;Biological;Biological Assay;biomarker driven;Biotechnology;Bone Marrow Transplantation;cancer cell;Cancer Cell Growth;Cancer Patient;cancer therapy;Canis familiaris;carcinogenesis;Cells;Certification;Cessation of life;Chemistry;chemoradiation;Chemotherapy and/or radiation;Chronic;Clinic;Clinical;Clinical Chemistry;Clinical Trials;Coagulation Process;commercialization;commercialization readiness;Data;Development;Dose;drug candidate;drug development;Drug Kinetics;drug production;Drug Targeting;Drug usage;efficacy study;Engineering;Ensure;Failure;Feedback;first-in-human;Food;Food and Drug Administration Drug Approval;Formulation;Funding;Future;Gel;Goals;Good Manufacturing Process;Grant;Head and Neck Cancer;head and neck cancer patient;Head and Neck Squamous Cell Carcinoma;healing;Hematology;Hematopoietic Neoplasms;high risk;Histopathology;HIV-1;Human;immunogenic;immunogenicity;improved;Inflammation;inhibitor;Institution;Intensity-Modulated Radiotherapy;Investigational Drugs;keratinocyte growth factor;Lead;Malignant Neoplasms;manufacture;manufacturing process;manufacturing test;meetings;mouse model;Mucositis;Mus;Names;New Drug Approvals;Normal tissue morphology;novel therapeutics;Oncogenic;Oral;Oral Administration;Oral cavity;oral mucositis;Oral mucous membrane structure;Oral Ulcer;Pain;pain reduction;Pathogenesis;Pathogenicity;Pathway interactions;Patient-Focused Outcomes;Patients;Penetration;Peptides;Pharmaceutical Preparations;pharmacodynamic biomarker;Pharmacodynamics;Pharmacology Study;Phase;Phase I Clinical Trials;phase I trial;Phase II/III Trial;Populations at Risk;prevent;Process;Production;programs;prophylactic;Proteins;quality assurance;Quality Control;Quality of life;Radiation;Radiation Dose Unit;Radiation therapy;Radio;Rattus;re-epithelialization;Readiness;Recommendation;Reference Standards;Regimen;Research;Risk;Rodent;Safety;scale up;Self Administration;side effect;Signal Transduction;Small Business Innovation Research Grant;Specific qualifier value;Squamous cell carcinoma;standard of care;targeted treatment;tat Protein;Testing;Therapeutic;Therapeutic Effect;Topical application;Toxic effect;Toxicokinetics;Toxicology;Treatment Protocols;Ulcer;United States Food and Drug Administration;Urinalysis

PROJECT_TITLE: IND-enabling toxicology studies to reach IND approval for a proprietary biologic to treat oral mucositis in cancer patients


ADMINISTERING_IC: NS

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences;Social Determinants of Health

ORG_DEPT: PHYSIOLOGY

PHR: Project Narrative Animals have evolved sophisticated sensory systems that allow them to sense and respond to environmental cues, optimizing their health and survival. The goal of this project is to identify the neuronal mechanisms that underlie sensory perception of harmful stimuli, such as the presence of dead conspecifics, and how these mechanisms elicit physiological changes that regulate lifespan in an invertebrate model, Caenorhabditis elegans. By identifying the specific mechanisms involved in this process will provide insight to exploit neural signaling in the treatment of aging-related physiologies.

PI_NAMEs: HERNANDEZ, MIRELLA  (contact)

PROGRAM_OFFICER_NAME: ULLRICH, LAUREN ELIZABETH

PROJECT_TERMS: Ablation;Address;Adult;Adverse effects;Adverse event;Affect;Afferent Neurons;Aging;aging related;Animal Model;Animals;Award;Behavior;Behavioral;Biology;Caenorhabditis elegans;Calcium;career;Cessation of life;Communication;Complex;Cues;Cyclic AMP-Dependent Protein Kinases;Cyclic GMP;Data;Detection;Disease;early life adversity;early life stress;emotion dysregulation;Environment;experimental study;Exposure to;Faculty;follow-up;Functional Imaging;G Protein-Coupled Receptor Signaling;G-Protein-Coupled Receptors;Gene Expression;Genetic;Glutamates;Goals;Guanylate Cyclase;Health;healthspan;Human;imaging approach;Impairment;improved;insight;Interneurons;Invertebrates;Knowledge;Leadership;Learning;Life Expectancy;life span;Link;Longevity;loved ones;Mediating;Mental Depression;Mental Health;Mentors;Modeling;Moods;Motor Neurons;Mus;Nematoda;Nervous System;neural circuit;neuronal circuitry;Neurons;neuropsychiatric disorder;neurotransmission;Neurotransmitters;Perception;Peripheral;Phase;physical conditioning;Physiological;Physiology;Positioning Attribute;Postdoctoral Fellow;prevent;Process;programs;Publications;Publishing;receptor;Regulation;release of sequestered calcium ion into cytoplasm;Reporter;Reporting;Research;Research Project Grants;response;Role;Sensory;sensory system;Signal Transduction;skills;Smell Perception;Stimulus;Stress;stress resilience;Stressful Event;Taxes;Technical Expertise;tenure track;Testing;Training;Work;Writing

PROJECT_TITLE: Perception of Dead Conspecifics modulates neural signaling and lifespan in Caenorhabditis elegans

STUDY_SECTION: NST

STUDY_SECTION_NAME: Neurological Sciences Training 3 Study Section[NST-3]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Networking and Information Technology R&D (NITRD);Prevention;Primary Health Care;Rural Health;Social Determinants of Health;Telehealth

ORG_CITY: NEW YORK

PHR: PROJECT NARRATIVE To achieve the Ending the HIV Epidemic: A Plan for America, better strategies are needed to promote antiretroviral (ART) adherence and viral suppression in persons living with HIV (PWH) from health disparity populations to engage them in HIV care and to reduce HIV risk behaviors during periods of non- suppression. In response, our study team has developed and demonstrated evidence for components of the CHAMPS+ intervention which will promote ART adherence and suppressed viral load for PWH who live in the Deep South, a geographic area of the US with high rates of new HIV infections and PWH who are virally unsuppressed.

PI_NAMEs: BATEY, DAVID S.;SCHNALL, REBECCA  (contact)

PROGRAM_OFFICER_NAME: FERNANDEZ, ANGELA R

PROJECT_TERMS: Address;Adherence;Adult;Alabama;Anti-Retroviral Agents;antiretroviral therapy;Area;Black Populations;Caring;Cessation of life;Chronic;Clinic;Clinical assessments;Clinical effectiveness;clinical efficacy;Communities;Community Health Aides;community organizations;Complex;Continuity of Patient Care;Counseling;Country;Data;Deep South;Development;Diagnosis;Disease;Disparity;effectiveness evaluation;Epidemic;epidemic preparedness;ethnic minority;Evaluation;evidence base;experience;Focus Groups;future implementation;General Population;Geographic Locations;Geography;Health;health disparity;health disparity populations;health literacy;Health Services Accessibility;Health Technology;Healthcare;Healthcare Systems;HIV;HIV Infections;HIV risk;HIV/AIDS;Human immunodeficiency virus test;Human Resources;implementation determinants;improved;Individual;innovation;Intervention;Intervention Trial;Life Expectancy;Literature;Location;Louisiana;Manuals;marginalized population;Medical;medication compliance;men who have sex with men;mHealth;Mississippi;Mobile Health Application;Modeling;multi-component intervention;New York City;Outcome;Patient Monitoring;Persons;Population;premature;prevent;primary outcome;Principal Investigator;Public Health;racial minority;Randomized;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;recruit;Regimen;Research;Research Design;resistance mutation;Resources;response;retention rate;Risk;Risk Behaviors;Risk Reduction;Rural;Sampling;scale up;secondary outcome;Self Management;Services;Sex Behavior;social;standard of care;substance use;success;Target Populations;Testing;Therapeutic;therapy adherence;Time;transgender women;Translations;transmission process;Treatment Protocols;United States;Viral;Viral Load result;Work

PROJECT_TITLE: Promoting Viral Suppression through the CHAMPS+ Intervention in the Deep South