NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Clinical Research;Dementia;Genetics;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research

ORG_CITY: PHILADELPHIA

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: In the US, 5.7 million people have AD. By 2050, this number will be 13.8 million. In 2017, AD costs the US $277 billion in medical and out of pocket expenses and $232 billion for the economic value of unpaid caregiving1. Presently, no treatments are available and additional drug targets are needed. Genetic studies described here can provide those new targets.

PI_NAMEs: SCHELLENBERG, GERARD DAVID (contact)

PROGRAM_OFFICER_NAME: YAO, ALISON Q

PROJECT_TERMS: Abbreviations;Affect;African American;African American population;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease risk;Alzheimer's disease therapy;Amyloid;Amyloid beta-Protein;Amyloid beta-Protein Precursor;Asian population;asymptomatic Alzheimer's disease;ATAC-seq;beta secretase;beta-site APP cleaving enzyme 1;biobank;Biochemical;Bioinformatics;Biological;Biological Assay;Biology;Cardiovascular system;Caribbean Hispanic;Caucasians;cell repository;chromosome conformation capture;clinical center;Cluster Analysis;Cognitive;cohort;Collaborations;Copy Number Polymorphism;cost;Cost of Illness;Country;Data;data enclave;Data Set;Data Storage and Retrieval;design;Development;Disease;disease phenotype;DNA;Drug Targeting;economic value;Environmental Risk Factor;Epigenetic Process;Episodic memory;Ethnic Origin;Ethnic Population;European;exome;exome sequencing;functional genomics;Funding;Gene Cluster;gene discovery;Genes;Genetic;genetic analysis;Genetic Diseases;Genetic Risk;Genetic study;genetic variant;genome wide association study;genome-wide;genome-wide analysis;Genomic approach;Genomics;Genotype;Goals;Haplotypes;Hispanic;Image;in silico;India;insertion/deletion mutation;International;Korea;Late Onset Alzheimer Disease;Link;Magnetic Resonance Imaging;Medical;Methods;Mexico;mild cognitive impairment;multi-ethnic;Neurofibrillary Tangles;neuropathology;new therapeutic target;next generation sequencing;Not Hispanic or Latino;novel;Pathway interactions;Peptides;Persons;Phenotype;phenotypic data;polygenic risk score;Positron-Emission Tomography;presenilin-1;presenilin-2;prevent;protein aggregation;Proteins;Quality Control;rare variant;Regulatory Element;Reporter;Research;Research Personnel;Resources;Risk;risk variant;Sample Size;Sampling;Senile Plaques;Signal Transduction;Single Nucleotide Polymorphism;South America;Spain;statistics;Taiwan;targeted therapy trials;targeted treatment;tau Proteins;Texas;therapeutic target;trait;Uninsured Medical Expense;Variant;whole genome;Work

PROJECT_TITLE: Alzheimer's Disease Genetics Consortium

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Basic Neuroscience of Aging Study Section[NIA-N]


ADMINISTERING_IC: DK

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: BAR HARBOR

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: JACKSON LABORATORY

ORG_STATE: ME

PHR: RELEVANCE TO PUBLIC HEALTH Type 1 diabetes (T1D) is a life threatening disease that results when T lymphocytes mount an aberrant autoimmune response that destroys insulin producing cells within the pancreas. However, it is now clear that B lymphocytes play an important role in supporting the activation of T1D inducing T lymphocyte responses. A B lymphocyte targeting strategy tested in a previous clinical trial was only partially effective as a possible T1D intervention approach, thus, the goal of the present proposal is to further identify developmental characteristics of T1D relevant B lymphocytes which may help identify a means to pharmaceutically eliminate or inactivate such cells.

PI_NAMEs: SERREZE, DAVID V (contact)

PROGRAM_OFFICER_NAME: SPAIN, LISA M

PROJECT_TERMS: Ablation;Acceleration;Address;anti-CD20;Antibodies;Antigen-Presenting Cells;Attenuated;Autoantibodies;Autoantigens;Autoimmune;Autoimmune Diabetes;autoimmune pathogenesis;Autoimmune Responses;Autoimmunity;autoreactivity;B-Lymphocytes;Beta Cell;Binding;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cell membrane;Cells;Characteristics;Clinical Trials;clinically relevant;Data;Defect;Development;diabetes risk;diabetogenic;Disease;Finding by Cause;Future;Genes;Genetic;genetic variant;Goals;Human;Immunoglobulin Class Switching;Immunoglobulin Somatic Hypermutation;Immunoglobulin Switch Recombination;Immunoglobulins;Immunosuppression;Inbred NOD Mice;insight;Insulin;insulin dependent diabetes mellitus onset;Insulin-Dependent Diabetes Mellitus;interest;Interleukin-10;Intervention;Islets of Langerhans;Life;Lymphocyte Depletion;Mediating;mouse model;MS4A1 gene;Multiple Sclerosis;Mus;Neuritis;Neurons;Onset of illness;Pancreas;Pathogenicity;Pathology;Patients;peripherin;Pharmacologic Substance;Phenotype;Play;Population;Predisposition;Process;protective effect;Public Health;Reagent;receptor;response;rituximab;Role;Specificity;Structure of beta Cell of islet;Surface Immunoglobulins;Syndrome;T cell response;T-Cell Activation;T-Lymphocyte;targeted treatment;Testing

PROJECT_TITLE: B-lymphocyte Targeting Therapies for Autoimmune Diabetes

STUDY_SECTION: HAI

STUDY_SECTION_NAME: Hypersensitivity, Autoimmune, and Immune-mediated Diseases Study Section[HAI]


ORG_CITY: La Jolla

ORG_NAME: SALK INSTITUTE FOR BIOLOGICAL STUDIES

ORG_STATE: CA

PHR: Exercise stimulates robust changes in skeletal muscle transcriptional programs, resulting in complex physiological outputs that elicit improvements in body health and performance. PGC1a, a focus of previous studies, is the transient ‘on switch‘ promoting nuclear receptors PPARd and ERRg to activate the oxidative transcriptional program. In contrast, this renewal proposa l focuses on the missing ‘off switch‘ program mediated by the corepressor BCL6, a conserved exercise regulated cofactor, that restores the basal metabolic states that precede and follow exercise.

PI_NAMEs: EVANS, RONALD M (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Acute;Address;Antioxidants;BCL6 gene;Bilateral;Binding;Binding Sites;Biotinylation;Cell Physiology;cell type;Chromatin;chromatin modification;Chronic;Cleavage Under Targets and Release Using Nuclease;cofactor;Complex;Cues;Data;Dependence;Development;Energy Metabolism;Epigenetic Process;epigenomics;Exercise;exercise capacity;Exercise Physiology;exercise regimen;exercise training;Fatty Acids;functional outcomes;gain of function;Gene Expression;Gene Expression Profile;gene network;gene repression;Genetic;genetic corepressor;Genetic Transcription;Glutathione Metabolism Pathway;Health;High Fat Diet;Histone Acetylation;Histone Deacetylation;Histones;Homeostasis;hormone regulation;Human;Immunoprecipitation;improved;inhibitor;Knock-out;Knockout Mice;Knowledge;Label;Laboratories;large cell Diffuse non-Hodgkin's lymphoma;Ligands;loss of function;Maps;Mediating;Metabolic;Metabolism;Modeling;Molecular;mouse model;Mus;Muscle;Muscle Fibers;muscle physiology;novel;Nuclear Receptors;Outcome;Output;Oxidative Stress;Performance;pharmacologic;Physiological;Physiology;postmitotic;PPAR delta;Process;programs;Proteins;Repression;response;Rest;Role;Running;sedentary;Skeletal Muscle;skeletal muscle metabolism;small molecule;targeted agent;Techniques;Technology;Testing;Tissues;Transcription Coactivator;Transcription Repressor;Transcriptional Activation;Transcriptional Regulation;transcriptomics

PROJECT_TITLE: Hormonal Regulation of Mammalian Gene Expression

STUDY_SECTION: MCE

STUDY_SECTION_NAME: Molecular and Cellular Endocrinology Study Section[MCE]


ADMINISTERING_IC: NS

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Cerebral Palsy;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Physical Rehabilitation;Rehabilitation

ORG_CITY: SEATTLE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Narrative The processes by which people with cerebral palsy adapt and learn to coordinate their muscles in order to move and explore the world remain unclear. To improve movement and function, new methods are needed to probe these processes and develop targeted treatments. The purpose of this research is to use feedback training to quantify walking adaptation and improve walking function for people with cerebral palsy.

PI_NAMEs: SCHWARTZ, MICHAEL HART;STEELE, KATHERINE M (contact)

PROGRAM_OFFICER_NAME: CHEN, DAOFEN

PROJECT_TERMS: Aftercare;Age;Ankle;Bilateral;Birth;Brain Injuries;Caring;Cerebral Palsy;Characteristics;Child;comparison control;Data;design;Diagnosis;Dorsal;Electromyography;Europe;Exhibits;experimental analysis;experimental study;Exposure to;Feedback;Flexor;gait examination;gait rehabilitation;Impairment;improved;Individual;Intervention;Joints;Knowledge;Learning;Leg;Length;Life;light weight;Measures;Methods;Modality;Motor;motor control;motor impairment;motor learning;Movement;multimodality;Muscle;Nervous System Trauma;neuromuscular;Operative Surgical Procedures;Orthopedic Surgery;Orthotic Devices;Outcome;Participant;Patients;Pattern;peer;Performance;Persons;Process;Quality of life;Randomized;rate of change;recruit;Research;Resistance;response;Rhizotomy procedure;Robot;robotic device;sex;Soleus Muscle;Speed;Symptoms;synergism;System;Time;Training;treadmill;Treatment outcome;treatment response;Visual;Walking;walking speed;wearable device;Work

PROJECT_TITLE: Quantifying patient-specific changes in neuromuscular control in cerebral palsy

STUDY_SECTION: MRS

STUDY_SECTION_NAME: Musculoskeletal Rehabilitation Sciences Study Section[MRS]


ED_INST_TYPE: SCHOOLS OF MEDICINE

NIH_SPENDING_CATS: Autoimmune Disease;Digestive Diseases;Inflammatory Bowel Disease

ORG_CITY: CLEVELAND

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: Public Health Relevance  Inflammatory bowel disease (IBD) affects more than a million people in the United States, alone, and there is presently no cure, with limited preventive measures for this condition. We recently discovered that the inflamed mouse and human colonic epithelium produces extracellular vesicles containing IL-1 family cytokines, including IL-1 and IL-18, that exacerbate T cell-mediated colitis and cause anti-TNF therapy failure. This application aims to provide mechanistic insight into this pathogenic cross-talk between intestinal epithelial cells and T cells, and to identify potential targets to address anti-TNF therapy failure using murine colitis models and clinical specimens from IBD patients.

PI_NAMEs: PIZARRO, THERESA TORRES (contact)

PROGRAM_OFFICER_NAME: PERRIN, PETER J

PROJECT_TERMS: adaptive immune response;Address;Affect;Anti-Tumor Necrosis Factor Therapy;Area;autocrine;Binding Proteins;Biogenesis;Biological Response Modifiers;Biopsy;Caspase;CDC37 gene;Cells;Cellular Stress;Chronic;Clinical;Colitis;Colon;Colonic inflammation;Communications Media;Complex;cytokine;Data;Detection;dextran sulfate sodium induced colitis;Disease;Environment;Environmental Risk Factor;Epithelial Cells;Epithelium;Etiology;exosome;extracellular vesicles;Family;Family member;gastrointestinal epithelium;Granulocyte-Macrophage Colony-Stimulating Factor;gut inflammation;Human;IL18 gene;Immune;Immune response;Inflammasome;Inflammation;Inflammatory;Inflammatory Bowel Diseases;Inflammatory Response;injured;insight;Interferon Type II;Interferons;Interleukin-1;Intestinal Content;intestinal epithelium;Knockout Mice;Length;Lipid Binding;Lytic;Macrophage;Mediating;member;Modeling;Molecular;Molecular Chaperones;Mucous Membrane;murine colitis;Mus;N-terminal;Nonlytic;novel;Organoids;Pathogenesis;Pathogenicity;Pathway interactions;Patients;Persons;Play;Polyubiquitination;pre-clinical research;Preventive measure;Production;Proteomics;public health relevance;recruit;Resistance;response;Role;Signal Transduction;Source;Specimen;Stimulus;success;Surface;T-Cell Activation;T-Lymphocyte;Testing;Therapeutic;Tissues;TNF gene;Treatment Failure;ubiquitin-protein ligase;United States;Vesicle

PROJECT_TITLE: The pathogenic roles of GSDMD-dependent gut epithelium extracellular vesicles in IBD

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-P(02)]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Services;Kidney Disease;Networking and Information Technology R&D (NITRD);Patient Safety

ORG_CITY: PITTSBURGH

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative Patients at high risk for acute kidney injury are often identified late and often do not receive recommended diagnostic and therapeutic interventions, with drugs being the most common cause; yet are potentially preventable. Clinical decision support to physicians in the form of automated alerts and pharmacist guidance for high-risk patients with drug-associated acute kidney injury (D-AKI) could dramatically improve risk assessment, medication use, and drug dosing in even non-drug-associated acute kidney injury. In this randomized control trial application, we will test whether adult hospitalized patients with D-AKI, cared for by physicians randomized to receive clinical decision support with an advanced pharmacist-led intervention, will have a lower risk for dialysis and premature death.

PI_NAMEs: BIHORAC, AZRA ;KANE-GILL, SANDRA L (contact)

PROGRAM_OFFICER_NAME: SCHULMAN, IVONNE HERNANDEZ

PROJECT_TERMS: Acute Renal Failure with Renal Papillary Necrosis;Address;Adopted;Adult;Adverse drug event;aging population;care providers;Caring;Cessation of life;Chronic;Clinical;clinical decision support;Clinical Decision Support Systems;Clinical Practice Guideline;clinical risk;comorbidity;Computerized Medical Record;cost;Cost Analysis;cost effectiveness;Coupled;Data;Death Rate;Decision Support Systems;Dependence;design;detection platform;Development;Diagnostic;Dialysis procedure;Dose;Drug Modelings;Early Diagnosis;Effectiveness;effectiveness evaluation;Electronics;Equipment;Etiology;Event;experience;Goals;group intervention;Guidelines;Health system;high risk;Hospitalists;Hospitalization;Hospitals;imaging agent;implementation cost;implementation intervention;improved;Incidence;Injury to Kidney;innovation;Institution;Intervention;Kidney Diseases;Laboratories;Length of Stay;Light;Machine Learning;Measures;Medical center;mortality;nephrotoxicity;non-drug;Operative Surgical Procedures;Outcome;Patient Care;Patient-Focused Outcomes;Patients;Perception;Performance;Pharmaceutical Preparations;Pharmacists;Physicians;post intervention;Predictive Analytics;Predictive Value;premature;Provider;Publishing;Randomized;Randomized, Controlled Trials;rate of aging;Recommendation;Recovery;renal damage;Reporting;Research;Residual state;Risk;Risk Assessment;risk prediction model;Series;Services;Site;Specificity;Staging;standard of care;Surveys;System;Testing;Therapeutic Intervention;Time;Training;United States;Universities;Update

PROJECT_TITLE: (MEnD-AKI) Multicenter Implementation of an Electronic Decision Support System for Drug-associated AKI

STUDY_SECTION: HSOD

STUDY_SECTION_NAME: Health Services Organization and Delivery Study Section[HSOD]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety

ORG_CITY: CORAL GABLES

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: Project Narrative We develop computationally efﬁcient hazard trees and forests for real-time risk prognostication for large scale time varying survival data.

PI_NAMEs: ISHWARAN, HEMANT  (contact)

PROGRAM_OFFICER_NAME: LIU, SONGTAO

PROJECT_TERMS: adverse outcome;Affect;American;Benchmarking;Cessation of life;Code;comorbidity;Computer software;cost;Data;data complexity;demographics;Devices;Dialysis procedure;Disease;Electronic Health Record;Ensure;Event;flexibility;forest;Goals;hazard;Hazard Models;health data;Heart;Heart failure;Heart Transplantation;hemodynamics;implantation;improved;Individual;Information Technology;innovation;Kidney Failure;Learning;left ventricular assist device;Libraries;Machine Learning;machine learning method;Measurement;mechanical circulatory support;Methodology;Methods;Modeling;Modernization;mortality;Multicenter Studies;novel strategies;open source;Organ failure;Patients;Performance;personalized risk prediction;platform-independent;population health;portability;predictive modeling;Procedures;Prognosis;prognostication;Risk;Risk Assessment;risk prediction;risk prediction model;statistics;success;Survival Analysis;System;Time;tool;Trees;Update;user friendly software;user-friendly;wearable device;web page;Writing

PROJECT_TITLE: Real time risk prognostication via scalable hazard trees and forests

STUDY_SECTION: ASPA

STUDY_SECTION_NAME: Analytics and Statistics for Population Research Panel A Study Section[ASPA]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Clinical Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research

ORG_CITY: NEW HAVEN

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Although increasing racial and ethnic diversity in the biomedical research workforce is a national priority, there is a dearth of evidence-based strategies to promote diversity. To address this important knowledge gap, we propose utilizing a positive-deviance methodology to identify strategies to promote the development of physician- scientist professional identity among medical students historically underrepresented in medicine by race/ethnicity. Results from our study have the potential to influence how medical schools train minoritized physician-scientists to build a more diverse biomedical research workforce.

PI_NAMEs: BOATRIGHT, DOWIN ;CHAUDHRY, SARWAT I (contact)

PROGRAM_OFFICER_NAME: STAMM, JOYCE CHIN-CHIN NG

PROJECT_TERMS: Accreditation;Address;Alaska Native;American;American Indians;aspirate;Association of American Medical Colleges;Attention;Behavior;Belief;Biomedical Research;Black Populations;Black race;career;Career Choice;Characteristics;Clinical;Clinical Medicine;Clinical Sciences;Communication;Data;Development;Disparity;Doctor of Philosophy;Ensure;Equity;ethnic diversity;Ethnic Origin;Ethnic Population;evidence base;Exclusion;experience;Funding;General Population;Generations;graduate school;Hispanic;improved;Individual;Influentials;innovation;Institution;interest;Interview;Knowledge;Latinx;Leadership;matriculation;Medical Education;medical schools;Medical Students;Medicine;Methodology;Methods;Minority;Native Americans;Native Hawaiian or Other Pacific Islander;Organizational Culture;Physicians;Play;podcast;Policies;Population;primary outcome;Process;programs;Publications;Questionnaires;Race;racial diversity;racial population;Research;Research Personnel;research study;Resources;Role;Sampling;Schools;Scientist;Shapes;Signal Transduction;Structure;Students;success;Surveys;Time;Training;United States;United States National Institutes of Health;uptake;Variant;web site;Work

PROJECT_TITLE: Developing Evidence to Improve Racial and Ethnic Diversity in the MD-Scientist Workforce

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HSS-W(02)M]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

ORG_CITY: RICHMOND

ORG_DEPT: CHEMISTRY

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: Narrative This project aims to develop catheter lock solutions containing a natural prodrug, S-nitrosoglutathione, to generate nitric oxide, a natural drug with potent antimicrobial and antithrombogenic properties. Nitric oxide releases from the catheter lumen as well as the exterior catheter surface, protecting the entire catheter from infectious and thrombotic complications. Our advanced formulations of S-nitrosoglutathione deliver safe and effective levels of nitric oxide to meet the locking needs of central venous catheters in applications such as hemodialysis and chemotherapy.

PI_NAMEs: WANG, XUEWEI  (contact)

PROGRAM_OFFICER_NAME: THAKAR, RAHUL GAUTAM

PROJECT_TERMS: Adoption;Animal Experiments;Animal Testing;Anti-Bacterial Agents;anti-microbial drug;Antibiotics;Anticoagulants;antimicrobial;aqueous;Bacteria;bacterial resistance;bactericide;Blood;Blood specimen;Catheters;Cells;Chemistry;chemotherapy;Chronic;Citrates;clinical application;clinical practice;combat;Complex;controlled release;Cyclodextrins;cytotoxicity;Data;design;diazeniumdiolate;Diffuse;Distal;Drug resistance;Drug usage;Endothelial Cells;Erythrocytes;Ethanol;Exhibits;experimental study;Family suidae;Formulation;Frequencies;Gases;Generations;Growth;Hemodialysis;Hemorrhage;Heparin;high risk;Human body;hydrophilicity;In Vitro;in vitro testing;Infection;infection risk;innovation;Kinetics;Legal patent;Length of Stay;Liquid substance;Lytic;Metals;Microbe;Microbial Biofilms;Modernization;Morbidity - disease rate;mortality;Multi-Drug Resistance;nano;nanocrystal;Nitric Oxide;Nitric Oxide Donors;novel strategies;Parenteral Nutrition;pathogen;Permeability;Pharmaceutical Preparations;Physiological;Polymers;Polyurethanes;porcine model;prevent;Prevention;Procedures;Prodrugs;Property;Propylene Glycols;Protocols documentation;Regimen;resistant strain;Risk;S-Nitrosoglutathione;S-Nitrosothiols;Safety;Saline;side effect;Silicone Elastomers;Solubility;Solvents;success;Surface;Suspensions;Testing;thrombogenesis;Thrombosis;thrombotic;thrombotic complications;Thrombus;Time;Tissues;tool;Toxic effect;Venous

PROJECT_TITLE: Antibacterial and Antithrombotic Catheter Lock Solutions Based on Controlled Release of Nitric Oxide

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;Immunization;Infectious Diseases;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Vaccine Related;Women's Health Research

ORG_CITY: NEW YORK

ORG_DEPT: PEDIATRICS

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: PUBLIC NARRATIVE Congenital cytomegalovirus (cCMV) infection is the leading infectious cause of birth defects in the US, causing long-term neurologic deficits, most commonly hearing loss, in up to 5,000 births each year in the US alone. This common infection, most dangerous to the fetus when acquired for the first time during pregnancy, is the cause of up to 25% of infant hearing loss. This project will use a unique cohort of 399 mothers acutely infected with CMV during pregnancy to define immune correlates associated with reduced fetal transmission and disease and define mechanistic impact of these responses in mathematical and placental organoid models.

PI_NAMEs: PERMAR, SALLIE R. (contact)

PROGRAM_OFFICER_NAME: DUPUY, LESLEY CONRAD

PROJECT_TERMS: Acute;Address;Antibodies;antibody-dependent cell cytotoxicity;Binding;Biological Assay;Birth;Blood donor;Brain Injuries;CD4 Positive T Lymphocytes;Cells;Child;Chronic;cohort;Complex;Computer Simulation;Congenital Abnormality;congenital cytomegalovirus;Cytomegalovirus;Cytomegalovirus Infections;Cytomegalovirus Vaccines;Dangerousness;Demographic Factors;design;Disease;disease transmission;Double-Blind Method;Enrollment;Enzyme-Linked Immunosorbent Assay;fetal;Fetal Diseases;fetal infection;Fetal Reduction;Fetus;Futility;Glycoproteins;Goals;hearing impairment;high risk;Human;Immune;Immune response;Immune Targeting;Immunity;immunogenicity;Immunoglobulin G;Immunologic Factors;Immunological Models;Impairment;in silico;Infant;Infection;Infusion procedures;Knowledge;Label;Licensing;Lifelong disability;Long term disability;Maps;Maternal-Fetal Medicine Units Network;Maternal-Fetal Transmission;Maternally-Acquired Immunity;Mathematics;Measures;Mediating;Minority Groups;Modeling;Molecular Conformation;Monkeys;Mothers;National Institute of Child Health and Human Development;Natural Killer Cells;Neurologic;Neurologic Deficit;nonhuman primate;novel;Organoids;Outcome;Placebos;Placenta;Population;predicting response;Predictive Factor;Pregnancy;pregnant;Pregnant Women;prevent;Prevention;Primary Infection;randomized trial;Randomized, Controlled Trials;response;Risk;Risk Factors;risk prediction;Risk Reduction;seroconversion;Signal Transduction;Speed;T cell response;T-Lymphocyte Subsets;Time;Tissue Model;Transfection;transmission process;trial design;Umbilical Cord Blood;United States National Institutes of Health;vaccine candidate;vaccine development;vaccine efficacy;vaccine trial;Vaccines;Viral;viral transmission;Virion;Virus;women's diagnosis;γδ T cells

PROJECT_TITLE: Identifying and modeling immune correlates of protection against congenital CMV transmission after primary maternal infection

STUDY_SECTION: IHD

STUDY_SECTION_NAME: Immunity and Host Defense Study Section[IHD]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

ORG_CITY: COLUMBIA

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

ORG_STATE: SC

PHR: Minority groups are generally under-represented among scientists who are conducting biomedical research. However, research benefits from interactions among scientists with diverse perspectives. Therefore, the success of UofSC PREP at increasing the pool of well-trained minority scientists will greatly benefit biomedical research.

PI_NAMEs: ARMSTRONG, ALISSA RICHMOND;ELY, BERT  (contact);HUNT, RICHARD C

PROGRAM_OFFICER_NAME: STEPANEK, LAURIE ELIZABETH

PROJECT_TERMS: Academia;Address;Admission activity;Award;Bachelor's Degree;Biomedical Research;career;Credentialing;Disadvantaged;Doctor of Philosophy;Education;education research;Employee;Employment;Environment;Equipment;Ethics;Evolution;experience;Exposure to;Faculty;falls;Family;Feedback;Financial Support;Funding;Goals;Government;graduate student;improved;Journals;Laboratories;Laboratory Research;Learning;matriculation;meetings;Mentored Research Scientist Development Award;Methods;Minority Groups;minority scientist;Participant;Pathway interactions;Peer Review;Perception;Postbaccalaureate;Postdoctoral Fellow;Poverty;programs;Publishing;Qualifying;recruit;Research;Scholars Program;Schools;Science;Scientist;skills;South Carolina;Students;success;support network;symposium;Training;Transcript;undergraduate student;Underrepresented Minority;underrepresented minority student;Underrepresented Students;United States;United States National Institutes of Health;Universities;verbal;Work

PROJECT_TITLE: UofSC Postbaccalaureate Research Education Program

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - D[TWD-D]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Neurosciences

ORG_CITY: BALTIMORE

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Narrative We investigate the brain mechanisms that underlie the ability of normal-hearing listeners to navigate complex acoustic environments, shift their attention between different sources of sound, and comprehend conversations in noisy environments. A clearer understanding of the mechanisms underlying these abilities will reveal the origin of selective- listening difficulties, and may inspire the design of more effective hearing aids and cochlear implants. Furthermore, malfunctions of both the prefrontal and auditory cortex are associated with neurological diseases such as tinnitus, dyslexia, and schizophrenia; and therefore, our research contributes to the basic understanding of cognitive control and pathways underlying neurological disorders.

PI_NAMEs: KANOLD, PATRICK O (contact)

PROGRAM_OFFICER_NAME: POREMBA, AMY

PROJECT_TERMS: Acoustics;Aging;Animals;Area;Attention;Auditory;Auditory area;Auditory Perception;auditory stimulus;awake;Behavior;behavior influence;Behavioral;Brain;Cells;Central Auditory Processing Disorder;Cochlear Implants;cognitive control;Complex;Computer Analysis;design;Detection;Deterioration;discrimination task;Disease;Dyslexia;Environment;Etiology;experimental study;frontal lobe;Genetic;Goals;Hearing Aids;Image;improved;in vivo;Individual;Label;Language;Measures;Motor;Mus;Nature;Nervous System Disorder;neural;Neurons;Noise;normal hearing;Optics;optogenetics;Output;Pathway interactions;Perception;Performance;Play;Population;Population Control;preference;Prefrontal Cortex;Property;receptive field;Recording of previous events;recruit;Research;response;Response to stimulus physiology;Schizophrenia;sensory input;Shapes;signal processing;Signal Transduction;sound;Source;Speech Perception;Stimulus;Structure;Symptoms;Task Performances;Testing;Thalamic structure;Tinnitus;two-photon;vocalization;Work

PROJECT_TITLE: Dynamic processing of sound in auditory cortex

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Nutrition;Obesity;Physical Activity;Prevention

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: Project Narrative  Increasing numbers of studies have indicated that, most fast food and common grocery items, contain large amount of phosphate-based food additives, which are highly absorbable. Our recent study in mice demonstrated that dietary phosphate loading that mimic the level of US consumption leads to reduced spontaneous locomotor activity, exercise capacity, and resting metabolic rate in normal mice by impairing skeletal muscle mitochondrial function and fat oxidation. Our current proposal aims to determine the relevance of animal observation in otherwise healthy humans, which may have a major public health implication in regard to optimal level of phosphate intake to maintain cardiovascular health.

PI_NAMEs: BERRY, JARETT D;VONGPATANASIN, WANPEN  (contact)

PROGRAM_OFFICER_NAME: SHIROMA, ERIC JITSUO

PROJECT_TERMS: Accelerometer;Adult;adverse outcome;Ancillary Study;animal data;Animals;ATP Synthesis Pathway;Attenuated;Basal metabolic rate;Bread;carbohydrate metabolism;cardiometabolic risk;cardiometabolism;cardiorespiratory fitness;cardiovascular health;Chronic Kidney Failure;Circulation;clinical practice;Consumption;Cross-Over Studies;Cross-Over Trials;Data;Diet;dietary;dietary excess;Dietary intake;Dietary Practices;Dietary Questionnaires;Down-Regulation;Energy Intake;Etiology;evidence based guidelines;Excretory function;Exercise;exercise capacity;exercise intolerance;fast food;Fatty acid glycerol esters;fatty acid oxidation;Fatty Acids;fibroblast growth factor 23;Food;Food Additives;food preparation;Freezing;Funding;Gene Expression Profile;General Population;Genes;Health;Heart;Human;Impairment;in vivo;inorganic phosphate;Insulin Resistance;Intake;Knowledge;Liver;Magnetic Resonance Imaging;Magnetic Resonance Spectroscopy;Meat;Metabolic;Metabolism;Mitochondria;mitochondrial dysfunction;Motor Activity;Mus;Muscle;Muscle Mitochondria;Nutritional;Obesity;oxidation;Oxygen;Participant;Pathogenicity;Physical activity;Pilot Projects;primary outcome;Process;prospective;Public Health;Randomized;Recommendation;Recommended Daily Allowances;respiratory;Rest;Risk Factors;secondary outcome;Series;Serum;Skeletal Muscle;soft drink;Testing;Theoretical model;translational study;trend;uptake;urinary;Visceral;Visceral fat;Work

PROJECT_TITLE: Impact of Dietary Phosphate Excess on Exercise Capacity and Visceral Adiposity

STUDY_SECTION: KNOD

STUDY_SECTION_NAME: Kidney, Nutrition, Obesity and Diabetes Study Section[KNOD]


NIH_SPENDING_CATS: Diabetes

ORG_CITY: Nashville

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: The goal of this study is to investigate how, in pancreatic islet beta cells, the networks of cytoskeletal polymers microtubules are built and regulated to optimize insulin vesicle biosynthesis, transport, and secretion. Deregulating microtubule networks causes abnormal insulin secretion in response to glucose stimulation and diabetes, which is indicative of their high physiological significance. We expect to uncover fundamental molecular mechanisms to help improve beta-cell function in our fight against diabetes.

PI_NAMEs: GU, GUOQIANG ;HOLMES, WILLIAM ;KAVERINA, IRINA  (contact)

PROGRAM_OFFICER_NAME: HWA, ALBERT J

PROJECT_TERMS: Active Biological Transport;Address;Affect;Alpha Cell;Anabolism;Architecture;Beta Cell;Binding Proteins;Biogenesis;Biological Assay;blood glucose regulation;Cell Communication;Cell membrane;Cell Nucleus;Cell Physiology;Cells;Centrosome;Complex;Computer Models;Cyclic AMP;Cytoplasm;Cytoskeleton;Data;Diabetes Mellitus;Dynein ATPase;Enhancers;Ensure;fighting;GLP-I receptor;Glucagon;Glucose;Goals;Golgi Apparatus;Grant;Human;Hyperinsulinism;Hypoglycemia;improved;Insulin;insulin granule;insulin secretion;intercellular communication;Intracellular Transport;islet;Islet Cell;Islets of Langerhans;Joints;Kinesin;mathematical model;Mediating;Metabolic Diseases;Microscopy;Microtubule Bundle;Microtubule Polymerization;Microtubule-Associated Proteins;Microtubules;Minus End of the Microtubule;Modeling;Molecular;Molecular Motors;Motor;Movement;Mus;Negative Finding;paracrine;Paracrine Communication;Peripheral;Physiological;Physiology;Population;Positioning Attribute;prevent;Production;Radial;Regulation;response;Role;Secretory Cell;Signal Transduction;Site;Slide;Stimulus;Structure;Structure of beta Cell of islet;tau Proteins;tau-1;Testing;Tissues;Vesicle;vesicle transport

PROJECT_TITLE: Microtubule Regulation of Pancreatic Beta Cell Function and Diabetes


NIH_SPENDING_CATS: Aging;Biotechnology;Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE Atrial and ventricular cardiac arrhythmias are a major cause of morbidity and mortality. Reactive oxidative stress, mitophagy, fibrosis and electrophysiological abnormalities are known to contribute to cardiac arrhythmias, however, there currently is no imaging to visualize and understand their mechanisms in arrhythmogenesis. The overall objective of this proposed project is to use a 3D panoramic imaging system to visualize these processes in transgenic murine hearts with atrial and ventricular arrhythmias to develop new treatment strategies for humans with arrhythmias.

PI_NAMEs: WAN, ELAINE Y (contact)

PROGRAM_OFFICER_NAME: BALIJEPALLI, RAVI C

PROJECT_TERMS: 3-Dimensional;Action Potentials;Address;adenovirus mediated delivery;Aging;aging population;Anatomy;Animal Model;Area;Arrhythmia;Atrial Fibrillation;Atrial Flutter;Atrial Tachycardia;Attenuated;Cardiac;Cardiac Myocytes;catalase;Cations;Clinical;Complex;Dependovirus;Detection;Diabetes Mellitus;DNA Sequence Alteration;effective therapy;Electrophysiology (science);Excision;experimental study;Fibrosis;Gene Transfer;Genes;Goals;grasp;Health;Heart;Heart Atrium;Heart failure;Heterogeneity;Human;Hypertension;Image;imaging system;Individual;innovation;Light;Maps;Mediating;Methodology;Mitochondria;mitochondrial dysfunction;Modeling;Modification;Morbidity - disease rate;mortality;mouse model;Multimodal Imaging;Mus;Mutation;Myocardial Infarction;novel;novel therapeutic intervention;Optics;optogenetics;Oxidative Stress;Pathway interactions;Pattern;Physiologic pulse;preservation;prevent;Process;Proteins;Reactive Oxygen Species;Reporter;Research;Resolution;Risk Factors;Role;Satellite Viruses;Sinus;Stroke;sudden cardiac death;System;Testing;Transgenic Mice;Transgenic Organisms;treatment strategy;Variant;Ventricular;Ventricular Arrhythmia;Ventricular Fibrillation;Ventricular Tachycardia;Visualization

PROJECT_TITLE: Understanding the role of mitochondrial dysfunction in cardiac arrhythmias using a novel 3D panoramic optical mapping system

STUDY_SECTION: ESTA

STUDY_SECTION_NAME: Electrical Signaling, Ion Transport, and Arrhythmias Study Section[ESTA]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative – MDRC Center Overview The MDRC oversees and provides research cores, enrichment activities and pilot and feasibility grant programs to support and enhance the national research effort related to diabetes. The MDRC promotes new discoveries and enhances scientific progress through the support of cutting-edge basic and clinical research by its highly interactive research base, which comprises 148 members at the University of Michigan (U-M) and regional partner institutions (Michigan State University (MSU), Ohio State University (OSU), the University of Toledo (UT), the Van Andel Institute (VAI), and Wayne State University (WSU).

PI_NAMEs: SOLEIMANPOUR, SCOTT  (contact)

PROGRAM_OFFICER_NAME: LYNCH, CHRISTOPHER

PROJECT_TERMS: Area;Awareness;base;Basic Science;bench to bedside;Biology;Clinical;Clinical Research;Communication;Complications of Diabetes Mellitus;Core Facility;Diabetes Mellitus;Diagnosis;Direct Costs;Disease;education research;empowerment;Endocrine System Diseases;Environment;Epidemic;experience;Fostering;Functional disorder;Funding;genetic approach;Genetic Research;Goals;Grant;Health Expenditures;Image Analysis;improved;Individual;innovation;Institution;interdisciplinary collaboration;interest;islet;Islets of Langerhans;Learning;member;Metabolic Diseases;Metabolism;Michigan;Microscopy;Mission;Molecular Genetics;Morbidity - disease rate;mortality;multidisciplinary;Nature;novel therapeutics;Ohio;Paper;Patients;Physiology;Prevalence;Productivity;programs;Public Health;Publishing;recruit;Research;Research Personnel;Research Project Grants;Research Support;Resources;Scientist;Secure;Services;Training;training opportunity;Translational Research;Translations;United States;Universities;web site

PROJECT_TITLE: Michigan Diabetes Research Center (MDRC)


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Bioengineering;Biomedical Imaging;Brain Disorders;Chronic Liver Disease and Cirrhosis;Dementia;Digestive Diseases;Epilepsy;Liver Disease;Neurodegenerative;Neurosciences;Rare Diseases

ORG_NAME: HUGO W. MOSER RES INST KENNEDY KRIEGER

PHR: NARRATIVE There is an ongoing effort to develop therapies for glycogen storage disease (GSD) but currently there is a lack of biomarkers to assess GSD progression and/or treatment efficacy non-invasively. We propose to develop a quantitative test for reporting glycogen load in muscle and brain using standard MRI equipment. This approach will result in a non-invasive tool for imaging glycogen changes in vivo with high spatial resolution and applicable to all glycogen storage diseases.

PI_NAMEs: YADAV, NIRBHAY NARAYAN (contact)

PROGRAM_OFFICER_NAME: LEENDERS, MIRIAM

PROJECT_TERMS: Adolescence;Affect;Aftercare;Age;Animal Diseases;Animals;Antibodies;Anticonvulsants;Astrocytes;Automobile Driving;autosome;Behavioral;Biochemical;Biological Markers;Biological Models;Brain;brain metabolism;Calibration;Cells;Cessation of life;Childhood;Clinical;Cognitive;computerized data processing;Cytoplasm;Data;Dementia;design;Detection;Deterioration;Diagnosis;Disease;Disease Progression;Enzymes;Epilepsy;Equipment;Etiology;Euthanasia;Feedback;Funding;Genes;Glucose;Glycogen;Glycogen Storage Disease;Grant;Human;Hydroxyl Radical;imaging approach;Imaging Device;imaging modality;Imaging Techniques;in vivo;instrumentation;Label;Lafora Disease;Liver;Liver Glycogen;Longitudinal Studies;Magnetic Resonance Imaging;Magnetism;Maps;Measures;Methods;molecular imaging;Monitor;mouse model;Mus;Muscle;Mutation;Neurodegenerative Disorders;neuroimaging;Neurons;Noise;non-invasive imaging;nonhuman primate;novel strategies;Nuclear;Organ;patient population;Phosphoric Monoester Hydrolases;Physiologic pulse;Predisposition;Protocols documentation;Protons;Publishing;radio frequency;Reporting;Resolution;Signal Transduction;Skeletal Muscle;soft tissue;solute;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;stem;Techniques;Technology;Testing;Therapeutic Intervention;therapy development;Tissues;Translations;Treatment Efficacy;ubiquitin-protein ligase;United States National Institutes of Health;Water;Work

PROJECT_TITLE: Non-Invasive Imaging of Neurological Glycogen Storage Disease

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]


PI_NAMEs: MYERS, MARTIN G (contact)

PROJECT_TERMS: Address;Advisory Committees;Advocate;Applications Grants;Appropriateness Review;Area;Award;Awareness;bench to bedside;Biomedical Research;Clinical Research;Collaborations;Communication;Consult;Data;Decision Making;Diabetes Mellitus;Disease;Effectiveness;empowerment;Endocrine System Diseases;Ensure;Environment;Equipment;Faculty;Funding;Goals;Grant;Individual;Infrastructure;Institution;interest;Laboratories;Leadership;Link;Maintenance;meetings;member;Metabolic Diseases;Michigan;multidisciplinary;National Institute of Diabetes and Digestive and Kidney Diseases;operation;Productivity;programs;prospective;Publications;Records;recruit;Reporting;Research;Research Personnel;Research Support;Resources;Secure;Services;Site;Source;Structure;Surveys;Training;Translations;web site

PROJECT_TITLE: Administrative Core


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

ORG_CITY: STORRS-MANSFIELD

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF CONNECTICUT STORRS

PHR: The proposed research aims to assess the multiple forms and paths of stigma and substance use as they relate to pre-exposure prophylaxis (PrEP) use for HIV prevention. How stigma and an evolving public health landscape impact PrEP use among BMSM who use substances is unknown. The current application focuses on addressing critical and novel questions to improving the essential building blocks of biomedical prevention approaches by providing crucial information for enhancing interventions to lower HIV prevalence among substance using BMSM.

PI_NAMEs: EATON, LISA A (contact)

PROGRAM_OFFICER_NAME: JENKINS, RICHARD A

PROJECT_TERMS: Address;Adherence;Affect;AIDS prevention;Awareness;Behavior;Behavioral;Biological;Biological Markers;black men who have sex with men;Blood;Caring;Cocaine;Connecticut;Continuity of Patient Care;Counseling;COVID-19;COVID-19 impact;Data;Disparity;Drug abuse;Dryness;ecstasy;efficacy testing;Eligibility Determination;Enrollment;Ethnic Origin;evidence base;Failure;follow-up;Guidelines;health care availability;Healthcare;Heroin;HIV;HIV Infections;HIV risk;HIV Seronegativity;HIV Seropositivity;HIV/AIDS;HIV/STD;Human immunodeficiency virus test;improved;Incidence;Individual;Infrastructure;Inhalant dose form;insight;interest;intersectionality;Intervention;Left;Longitudinal Studies;marijuana use;Measures;Mediating;men who have sex with men;Methamphetamine;Modeling;Nitrates;novel;Opioid;Outcome;Participant;participant enrollment;Pathway interactions;Population;Positioning Attribute;pre-exposure prophylaxis;Prevalence;prevent;Prevention approach;Procedures;Process;Prospective cohort;Psychosocial Assessment and Care;Public Health;Race;racial disparity;recruit;Reporting;Research;response;Risk;Role;Sex Behavior;sexually active;Site;social stigma;social structure;Southeastern United States;Spottings;substance use;substance user;Testing;Toxicology;Translating;transmission process;Treatment Efficacy;United States National Institutes of Health;Universities;uptake;Vulnerable Populations;Work

PROJECT_TITLE: Stigma and Substance Use as Barriers to PrEP Linkage, Uptake, Adherence, and Persistence among BMSM

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


NIH_SPENDING_CATS: Cardiovascular;Heart Disease

ORG_CITY: CHARLESTON

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

PHR: Recent studies in the mouse have shown that during development, epicardially-derived cells (EPDCs) contribute to the formation of the atrioventricular valves. When this process is perturbed, mice develop abnormal valves, that are very similar to those seen in humans with Myxomatous Valve Disease (MVD). Increasing our insight into how EPDCs contribute to the developing valves in health and disease may further our understanding of the pathogenesis of valve disease in humans.

PI_NAMEs: WESSELS, ARNO  (contact)

PROGRAM_OFFICER_NAME: EVANS, FRANK

PROJECT_TERMS: Area;Birth;BMPR1A gene;bone morphogenetic protein receptors;Bone Morphogenetic Proteins;Cell Lineage;Cells;Collagen Type IV;Compensation;Development;Disease;Embryo;Endocardium;Epicardium;Event;Extracellular Matrix;Goals;Growth Factor;Health;Heart;Human;insight;Integrin alpha4;Knock-out;Lateral;Life;Mesenchymal;migration;Mitral Valve;Mitral Valve Insufficiency;Mitral Valve Prolapse;MMP2 gene;Modeling;Mus;Parietal;Pathogenesis;Pathway interactions;Patients;Pattern;Phenotype;postnatal;Process;Proliferating;Publications;Publishing;Reporting;Research Proposals;Role;Series;Signal Transduction;Testing;Time;transcription factor;Vascular Cell Adhesion Molecule-1

PROJECT_TITLE: Role of the Epicardium in Valve Development and Valve Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CVRS-C(02)]


NIH_SPENDING_CATS: Clinical Research;Diabetes

PI_NAMEs: HERMAN, WILLIAM H (contact)

PROJECT_TERMS: Acceleration;Address;Animals;Basic Science;bench to bedside;Biomedical Research;Biometry;Clinical;clinical center;Clinical Data;Clinical Investigator;Clinical Research;Collaborations;comorbidity;cost;Data;Data Analyses;data management;design;Devices;Diabetes Mellitus;diabetic;Effectiveness;Electronic Health Record;Endocrine System Diseases;Environment;Equipment;Experimental Designs;Goals;Health;Human;human subject;Laboratories;Metabolic Diseases;Michigan;Molecular;multidisciplinary;Nature;novel therapeutics;Patients;Personal Satisfaction;Persons;Populations at Risk;preclinical development;Process;Quality Control;recruit;Research;Research Design;Research Personnel;Research Subjects;Resources;Risk;Services;Testing;treatment program;Universities

PROJECT_TITLE: Clinical Core


ORG_CITY: IOWA CITY

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Project Narrative Developing a functional cure for HIV/AIDS requires further studies of HIV-1 and host interactions. We will investigate how HIV-1 RNA modifications regulate viral latency and persistence in CD4+ T cells from HIV-1- infected individuals on antiretroviral therapy. Understanding mechanisms of post-transcriptional regulation of HIV-1 RNA will help develop therapeutic strategies to target RNA modifications for inhibiting HIV-1 replication.

PI_NAMEs: WU, LI  (contact)

PROGRAM_OFFICER_NAME: LACOURCIERE, GERARD

PROJECT_TERMS: Address;Adult;Anti-viral Agents;antiretroviral therapy;CD4 Positive T Lymphocytes;Cell Line;Cells;cellular targeting;Critical Pathways;design;Development;Drug Targeting;epitranscriptomics;Funding Opportunities;Gene Expression;Genetic Transcription;HIV;HIV 1 Envelope Protein gp120;HIV-1;HIV/AIDS;Immune response;In Vitro;in vivo;Individual;Infection;inhibitor;Innate Immune Response;knock-down;Knock-out;Knowledge;latent HIV reservoir;Macrophage;Memory;Modification;multidisciplinary;Natural Immunity;novel;novel strategies;novel therapeutic intervention;Pathway interactions;Patients;Peripheral Blood Mononuclear Cell;Phase;Play;Post-Transcriptional Regulation;Post-Transcriptional RNA Processing;posttranscriptional;power analysis;Proteins;Proviruses;Reader;Regulation;Reporting;Rest;RNA;Role;small molecule;T cell therapy;T-Lymphocyte Subsets;Testing;Therapeutic;therapeutic development;therapeutic target;transcriptome sequencing;Translating;Up-Regulation;Viral;Viral reservoir;Virus Diseases;Virus Latency;Virus Replication

PROJECT_TITLE: Targeting HIV-1 RNA modifications in latently infected CD4+ T cells for therapeutic development


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Eye Disease and Disorders of Vision;Hearing Loss;Neurosciences

ORG_CITY: DURHAM

ORG_DEPT: PSYCHOLOGY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: HEALTH RELEVANCE STATEMENT Understanding how active mechanisms in the ear participate in signaling the occurrence of eye movements will shed light on how vision contributes to hearing. This work is relevant to both hearing disorders (e.g. sensorineural and age-related hearing loss), as well as a broad array of conditions involving communication deficits more generally (e.g. dyslexia, autism, and age-related cognitive impairments).

PI_NAMEs: GROH, JENNIFER M (contact)

PROJECT_TERMS: Affect;Age-associated memory impairment;Animal Model;Auditory;Auditory area;auditory pathway;Auditory Perception;auditory processing;Auditory system;autism spectrum disorder;Bell Palsy;Brain;brain control;Cochlea;Cognition Disorders;Communication;Compensation;Complex;design;Dyslexia;Ear;ear muscle;Elements;evaluation/testing;experimental study;External auditory canal;Eye;Eye Movements;Facial nerve structure;Functional disorder;Head;Health;Hearing;hearing impairment;Hearing problem;Human;Injections;Inner Hair Cells;Interruption;Intervention;Investigation;Kanamycin;Labyrinth;Macaca mulatta;microphone;middle ear;Monkeys;Motion;Motor;multimodality;Muscle;Nature;normal hearing;novel;oculomotor;Operative Surgical Procedures;otoacoustic emission;ototoxicity;Outer Hair Cells;Participant;Patients;Perception;Performance;Peripheral;Pharmaceutical Preparations;Population;Presbycusis;Process;Reflex action;retinal imaging;Role;Sensorineural Hearing Loss;Sensory;Shapes;Signal Transduction;sound;Stapedectomies;stapedius muscle;Stream;Structure;System;tensor tympani muscle;Testing;Tympanic membrane;Vestibular function;Vision;Visual System;Work

PROJECT_TITLE: Mechanisms of Oculomotor Influences on Hearing


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_CITY: BERKELEY

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: Narrative This project will reveal how neural coding, plasticity and selective attention are organized within intermixed, non-topographic representations in cerebral cortex. Mouse somatosensory cortex is used as a model system. This basic research on cerebral cortex function will enable future investigation of neural circuit and coding deficits in neurodevelopmental disorders such as autism and ADHD.

PI_NAMEs: FELDMAN, DANIEL  (contact)

PROGRAM_OFFICER_NAME: OSBORNE, LESLIE CAROL

PROJECT_TERMS: Anatomy;Attention;Attention deficit hyperactivity disorder;attentional modulation;autism spectrum disorder;Basic Science;Biological Models;Calcium;Capsicum;Cells;Cerebral cortex;Code;cognitive process;Cues;Data;Detection;discrimination task;Equilibrium;experience;flexibility;Future;Image;improved;Interneurons;Investigation;Learning;Maps;Measures;Modeling;Mus;Nature;Neighborhoods;neural;neural circuit;Neurodevelopmental Disorder;Neurons;novel;optogenetics;Output;Pattern;Performance;Property;Psychological reinforcement;Pyramidal Cells;Recording of previous events;response;Rewards;Rodent;Role;Sampling;segregation;selective attention;Sensory;sensory cortex;Site;Sodium Chloride;Somatosensory Cortex;Specificity;Stimulus;Structure;Testing;two-photon;Vibrissae;whisker discrimination

PROJECT_TITLE: Organization of neural coding and plasticity in L2/3 of mouse S1 cortex

STUDY_SECTION: SMN

STUDY_SECTION_NAME: Sensory-Motor Neuroscience Study Section[SMN]


NIH_SPENDING_CATS: Biotechnology;Diabetes;Genetics

PI_NAMEs: OLSON, DAVID P (contact)

PROJECT_TERMS: Animal Model;Animals;Biomedical Research;blastocyst;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;complex biological systems;Consultations;CRISPR/Cas technology;Custom;design;Development;Diabetes Mellitus;Doctor of Philosophy;Effectiveness;Embryo;empowerment;Endocrine System Diseases;Functional disorder;gene editing technology;Generations;Genetic;Genetic Engineering;Genetic Models;Genetic Techniques;Genotype;Grant;Guide RNA;Human;human disease;human model;improved;in vivo evaluation;Individual;Injections;innovation;insight;Knock-out;Laboratories;Laboratory Personnel;Learning;Marketing;member;Metabolic Diseases;method development;Methodology;Methods;Michigan;model development;model organism;Modeling;Modernization;Molecular;Molecular Genetics;molecular modeling;Mus;new technology;novel;novel strategies;Physiological;Physiology;programs;Protocols documentation;Rattus;Reagent;Research;Research Personnel;Research Project Grants;Rodent;Rodent Model;Running;screening;Services;success;System;Techniques;Technology;tool;Training;Transgenic Animals;vector;Viral;Viral Vector;viral vector development;Work

PROJECT_TITLE: Molecular Genetics Core


NIH_SPENDING_CATS: Clinical Research;Diabetes;Stem Cell Research;Stem Cell Research - Embryonic - Human

PI_NAMEs: HUSSAIN, MEHBOOB A (contact)

PROJECT_TERMS: Acceleration;Applications Grants;Area;Award;Biomedical Research;career;Clinical;Clinical Research;Collaborations;Communication;Cost Sharing;Data;Diabetes Mellitus;Discipline;Eligibility Determination;Endocrine System Diseases;Equilibrium;Expenditure;Extramural Activities;Faculty;follow-up;Fostering;Funding;Goals;Grant;Grant Review;innovation;Institution;Instruction;interdisciplinary collaboration;Interdisciplinary Study;interest;Manuscripts;member;Metabolic Diseases;Michigan;Monitor;Paper;Peer Review;prevent;Process;programs;Progress Reports;Publications;Publishing;Recording of previous events;recruit;Reporting;Research;research faculty;Research Personnel;Research Support;Resources;Review Committee;Schools;Science;Time;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Pilot and Feasibility Program


PROJECT_TERMS: Acceleration;Agreement;Applications Grants;Area;Award;Biomedical Research;career;Clinical Research;Collaborations;Communication;Cost Sharing;Data;Diabetes Mellitus;Eligibility Determination;Endocrine System Diseases;Expenditure;Extramural Activities;Faculty;Funding;Goals;Grant;innovation;Institution;Instruction;interdisciplinary collaboration;interest;Metabolic Diseases;Michigan;Monitor;National Institute of Diabetes and Digestive and Kidney Diseases;Ohio;Paper;Peer Review;prevent;Process;programs;Progress Reports;Publications;Publishing;Recording of previous events;recruit;Reporting;Research;research faculty;Research Personnel;Research Support;Resources;Science;success;United States National Institutes of Health;Universities

PROJECT_TITLE: Expanded (Regional) Pilot and Feasibility Program


NIH_SPENDING_CATS: Autoimmune Disease;Brain Disorders;Clinical Research;Neurosciences;Orphan Drug;Rare Diseases

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PI_NAMEs: BENAVIDES, DAVID ROGER (contact)

PROGRAM_OFFICER_NAME: REZAIZADEH, KAVON PAUL

PROJECT_TERMS: Address;Agitation;Antibodies;Area;Autoimmune encephalitis;Binding;Brain;Brain Diseases;career;career development;Cell Surface Proteins;Central Nervous System;Clinical;Coma;Data;Development Plans;Dissociation;Doctor of Medicine;Doctor of Philosophy;Drug usage;Educational workshop;Encephalitis;experience;Fc Receptor;Functional disorder;Genetic Predisposition to Disease;Glutamate Receptor;Glutamates;Goals;Hippocampus;Human;immunoregulation;in vivo;Individual;innovation;Instruction;live cell microscopy;Maryland;medical schools;Memory impairment;Mentors;Molecular;Morbidity - disease rate;mortality;Movement Disorders;N-Methyl-D-Aspartate Receptors;Nervous System Disorder;neuroimmunology;Neurology;neuronal circuitry;Neurons;Neurophysiology - biologic function;Neurosciences;Neurosciences Research;neurotransmission;Neurotransmitter Receptor;new therapeutic target;novel therapeutics;Physicians;Positioning Attribute;Principal Investigator;professor;Program Development;Proteomics;Psychoses;Receptor Signaling;release of sequestered calcium ion into cytoplasm;Research;Research Personnel;Research Project Grants;Research Training;Rodent;Scientist;Seizures;Signal Pathway;Signal Transduction;skills;Synaptic plasticity;Synaptic Transmission;Technology;Training;translational neuroscience;Translational Research;Universities;Work

PROJECT_TITLE: Impact of human anti-NMDA receptor antibodies on glutamate receptor signaling, calcium mobilization, and hippocampal neuronal circuits in autoimmune encephalitis

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-1 Study Section[NST-1]


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Liver Disease;Neurodegenerative;Rare Diseases

ORG_DEPT: PHYSIOLOGY

PHR: PROJECT NARATIVE This project will determine how different cell types in the liver, intestine, and bone marrow respond to Atp7b inactivation and how they work together to produce the Wilson disease phenotype. The results of this project will help to better understand the pathogenesis of Wilson disease and identify new approaches to treatment.

PI_NAMEs: HAMILTON, JAMES P;LUTSENKO, SVETLANA  (contact)

PROGRAM_OFFICER_NAME: BURGESS-BEUSSE, BONNIE L

PROJECT_TERMS: Affect;Attenuated;Bile Acids;Bone Marrow;Calories;Carrier Proteins;Cell Communication;Cell Differentiation process;cell type;Cells;Characteristics;chelation;Cirrhosis;Clinical;Copper;Cytoplasmic Granules;Data;Development;Diagnosis;Diet;Dietary Fats;Disease;disease phenotype;Disease Progression;disease-causing mutation;DNA Sequence Alteration;Enterocytes;Evaluation;Experimental Models;Extrahepatic;Fatty Liver;Female;Fibrosis;Funding;Genetic;Genetic Transcription;Goals;Hematology;Hepatic;Hepatic Tissue;Hepatitis;Hepatocyte;Hepatolenticular Degeneration;Homeostasis;Immune;Immune response;In Situ;Inflammation;Inflammatory Response;Injections;Interruption;Intervention;Intestines;islet;Kidney;Knockout Mice;Label;Leukocytes;Ligands;Link;lipidome;Liver;Liver diseases;liver function;liver inflammation;male;Measures;Messenger RNA;Metabolic;Metabolic Diseases;Metallothionein;Metals;Methodology;Modeling;Mouse Strains;Mus;Mutation;Myelogenous;Myeloid Cells;Myeloid Progenitor Cells;Neurologic;Neutropenia;neutrophil;nonalcoholic steatohepatitis;novel strategies;Nuclear Receptors;Onset of illness;Oxidative Stress Induction;Pathogenesis;Patients;Phenotype;progenitor;Prognosis;programs;Protocols documentation;receptor expression;Receptor Inhibition;response;Role;secretory protein;Sex Differences;side effect;Signal Transduction;single cell sequencing;standard of care;stellate cell;Sterols;Testing;Time;Tissues;Transcript;transcriptome;Treatment outcome;Update;Western Blotting;Wilson disease protein;Work

PROJECT_TITLE: Copper Homeostasis and Liver Function

STUDY_SECTION: NMHD

STUDY_SECTION_NAME: Nutrition and Metabolism in Health and Disease Study Section[NMHD]


NIH_SPENDING_CATS: Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Neurosciences;Pediatric

ORG_CITY: WASHINGTON

ORG_NAME: CHILDREN'S RESEARCH INSTITUTE

ORG_STATE: DC

PHR: PROJECT NARRATIVE To bring neurosciences to the forefront of STEM and health care research, Mentored Experiences to Expand Opportunities in Research version 3 (“METEOR v. 3”) will provide hands-on research experiences for local high school students and STEM teachers-in-training during the summer academic break with continued activities through the school year. METEOR v. 3 will immerse Washington, DC metro area high schoolers and future STEM teachers from diverse cultural, ethnic, and socioeconomic backgrounds into inquiry-based biomedical, behavioral, and clinical research at Children’s National Hospital and its Research Institute. With a comprehensive mentorship program and core curriculum, METEOR v. 3 will employ unique, research-based educational practices designed to stimulate interest and advance knowledge in the neurosciences, neurobiology, and related fields.

PI_NAMEs: LUBAN, NAOMI L (contact);TRIPLETT, JASON

PROGRAM_OFFICER_NAME: MATTHEWS, MARGUERITE

PROJECT_TERMS: Advisory Committees;Animal Experimentation;Area;Basic Science;behavioral health;Behavioral Research;Biomedical Research;Brain;brain based;Brain Diseases;Career Choice;Child;Child Health;Childhood;Clinical Research;Community Health;community research;Competence;computer program;Data;design;Development;Education;Educational Curriculum;Educational Models;Educational process of instructing;Ensure;Ethics;Ethnic Origin;Evaluation;experience;Faculty;Future;hands on research;Health;health care disparity;Health Care Research;health equity;Healthcare;Hearing;high school;High School Student;Hospitals;Human;Human Characteristics;improved;innovation;Instruction;Interdisciplinary Study;interest;K-12 Education;Knowledge;Laboratories;Laboratory Research;Lead;Learning;lens;Link;literacy;Mentors;Mentorship;Methods;Modeling;Nature;Nervous System;Neurobiology;neurodevelopment;Neurodevelopmental Disability;Neurosciences;Neurosciences Research;next generation;Oncology;pandemic disease;patient engagement;peer;Peripheral Nerves;Play;Professional Competence;programs;Research;Research Institute;Research Personnel;Research Project Grants;Role;Safety;Schools;Science;Science, Technology, Engineering and Mathematics;Science, Technology, Engineering and Mathematics Education;Signal Transduction;Site;Sleep;socioeconomics;Speech;Spinal Cord;Students;teacher;teacher mentor;Time;Training;Translational Research;Trauma;Underrepresented Populations;Vaccines;Washington

PROJECT_TITLE: Mentored Experience to Expand Opportunities in Research version 3 (METEOR v. 3)

STUDY_SECTION_NAME: Special Emphasis Panel[ZNS1 SRB-D (27)]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: HOUSTON

ORG_NAME: METHODIST HOSPITAL RESEARCH INSTITUTE

PHR: Project Narrative Mitochondrial bioenergetics and oxidative phosphorylation can influence all key processes linked to early oncogenesis. This proposal will investigate whether enhanced delivery of phenethyl isothiocyanate (PEITC) to mitochondria via mitochondria-targeting strategy will help to define the mitochondrial mechanisms and efficacy of Mito-PEITC on lung oncogenesis and metastasis.

PI_NAMEs: YOU, MING  (contact);ZIELONKA, JACEK M

PROGRAM_OFFICER_NAME: CLIFFORD, JOHN LEO

PROJECT_TERMS: A/J Mouse;Adenocarcinoma Cell;analog;animal imaging;Animal Model;Apoptosis;Biochemical;Bioenergetics;Biological Assay;Biological Markers;bioluminescence imaging;blood-brain barrier crossing;Brain;Breast Cancer Cell;breast cancer metastasis;cancer cell;cancer type;Cancerous;carcinogenesis;Cations;cell growth;Cells;Chemistry;Chemoprevention;Chemopreventive Agent;cold temperature;Complex;cruciferous vegetable;Data;design;Development;Disease;disorder control;Dose;efficacy evaluation;Electron Spin Resonance Spectroscopy;Electron Transport;Energy Metabolism;Engraftment;Event;former smoker;Gene Modified;Glutathione;Growth;Homeostasis;Human;Imaging technology;implantation;In Vitro;in vivo;in vivo fluorescence imaging;in vivo imaging;in vivo monitoring;Individual;Induction of Apoptosis;inhibitor;Injections;innovation;insight;Invaded;Ions;Left ventricular structure;Link;lipophilicity;Lung;Lung Adenocarcinoma;lung cancer cell;lung carcinogenesis;Lung Neoplasms;lung tumorigenesis;Magnetic Resonance Imaging;Malignant neoplasm of lung;Mediating;member;Membrane Potentials;Metastatic malignant neoplasm to brain;Metastatic Neoplasm to the Lung;Mitochondria;mitochondrial membrane;Monitor;mortality;mouse model;Mus;NADH dehydrogenase (ubiquinone);Natural Compound;Neoplasm Metastasis;neoplastic cell;NOD/SCID mouse;Non-Small-Cell Lung Carcinoma;Normal Cell;novel;Oncogenic;Oxidants;oxidation;Oxidation-Reduction;Oxidative Phosphorylation;Oxygen Consumption;Parents;Patients;Pattern;peroxiredoxin;Phenethyl Isothiocyanate;Phosphorylation;Populations at Risk;premalignant;prevent;Prevention;Preventive;Preventive treatment;Primary Neoplasm;Process;Production;Proteomics;Rattus;Reactive Oxygen Species;Reporting;Respiration;response;Risk;Role;Safety;side effect;Signal Pathway;Signal Transduction;single-cell RNA sequencing;STAT3 gene;targeted agent;Testing;Time;treatment strategy;tumor;tumor initiation;tumor progression;tumor-immune system interactions;tumorigenesis;ultrasound;United States

PROJECT_TITLE: Targeting phenethyl isothiocyanate to mitochondria in lung carcinogenesis

STUDY_SECTION: CPSS

STUDY_SECTION_NAME: Cancer Prevention Study Section[CPSS]


ORG_CITY: PITTSBURGH

ORG_DEPT: PHYSICAL MEDICINE & REHAB

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE Humans with stroke lesion invading the cortico-spinal tracts (CST) suffer from the most severe and permanent motor deficits, which include loss of finger dexterity and muscle weakness. Here, we aim at designing a new deep brain stimulation therapy to treat post-stroke muscle weakness and motor paresis by targeting the motor thalamus, i.e., a subcortical relay with outgoing excitatory connectivity to sensory/motor cortices. For this, we will demonstrate that motor thalamus stimulation increases the excitability of the motor cortex and that these excitatory inputs can potentiate motor output in intact animals and animals with chronic lesions of the CST both when anesthetized and during behaving motor tasks.

PI_NAMEs: GONZALEZ-MARTINEZ, JORGE ALVARO;PIRONDINI, ELVIRA  (contact)

PROGRAM_OFFICER_NAME: DOPERALSKI, ADELE ELIZABETH

PROJECT_TERMS: Affect;Anesthesia procedures;Animals;Anterolateral;Area;awake;Behavioral;Brain;Cell Nucleus;Cervical;Chemosensitization;Chronic;chronic stroke;Clinical;Clinical Trials;clinically relevant;conditioning;Corticospinal Tracts;Data;Data Analyses;Deep Brain Stimulation;design;Development;dexterity;disability;Electrocoagulation;Electrodes;Electrophysiology (science);Essential Tremor;Evoked Potentials;experience;experimental study;FDA approved;Fingers;follow-up;Forearm;Frequencies;functional improvement;Future;Goals;Hand;Human;Impairment;Implant;implantation;improved;Individual;Internal Capsule;Intervention;Invaded;Lateral;Lead;Length;Lesion;Measures;Modeling;Monkeys;Motivation;Motor;Motor Cortex;motor deficit;Motor disability;Motor Evoked Potentials;motor impairment;Motor Neurons;Motor output;motor recovery;motor symptom;Movement Disorders;Muscle;Muscle Weakness;neural;Neuronal Plasticity;Neurons;neuroregulation;neurosurgery;neurotransmission;novel;Paralysed;Paresis;patient population;Patients;Pattern;Performance;Persons;Physical therapy;Population Sizes;Positioning Attribute;post stroke;pre-clinical;Protocols documentation;Recovery;robot assistance;Sensory;sensory cortex;Severities;Source;spasticity;Specificity;spinal pathway;Stroke;stroke model;stroke patient;Structure;Synapses;Techniques;Technology;Testing;Thalamic structure;therapeutically effective;Training;Translations;United States;Upper Extremity;white matter;Work

PROJECT_TITLE: Deep brain stimulation of the motor thalamus to improve cortico-spinal control of muscles after stroke

STUDY_SECTION: BNVT

STUDY_SECTION_NAME: Bioengineering of Neuroscience, Vision and Low Vision Technologies Study Section[BNVT]


ADMINISTERING_IC: EY

ED_INST_TYPE: PRIMATE CENTERS

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: SEATTLE

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: PROJECT NARRATIVE  In humans and in other primate species, binocular coordination of the eyes is crucial for normal visual perception. Our studies are designed to investigate the contribution of the vergence system to the unequal eye movements that occur between targets that differ in both direction and distance.

PI_NAMEs: WALTON, MARK M (contact)

PROGRAM_OFFICER_NAME: ARAJ, HOUMAM H

PROJECT_TITLE: Neurophysiology of Disjunctive Saccades

STUDY_SECTION: NBVP

STUDY_SECTION_NAME: Neuroscience of Basic Visual Processes Study Section[NBVP]


ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: Project Narrative Our research goal is to understand how neuronal dendrites in the mammalian retina compute motion signals. A comprehensive understanding of motion detection at the dendritic level is a critical first step towards understanding normal visual motion detection, and treating visual dysfunction that occurs in diseased states. Furthermore, the knowledge gained from the proposed study will have broader implications as it will address the general principles of neural computation in the brain.

PI_NAMEs: WEI, WEI  (contact)

PROGRAM_OFFICER_NAME: WRIGHT, CHARLES BAKER

PROJECT_TERMS: Affect;Algorithms;Behavior;Behavioral Assay;biophysical properties;Brain;Calcium;Calcium Spikes;cell type;Complement;Coupling;Dendrites;Detection;Disease;Distal;Ensure;ganglion cell;Glutamates;Goals;Image;insight;Knowledge;Link;Location;Mammalian Cell;Measurement;Membrane;metabotropic glutamate receptor 2;Modeling;Monitor;Morphology;Motion;Mus;neural;neuronal cell body;Neurons;Output;patch clamp;Pattern;Photic Stimulation;postsynaptic;Prevalence;Process;Property;Radial;receptor;Reflex action;Research;response;Retina;retinal neuron;Role;Signal Transduction;spatiotemporal;starburst amacrine cell;Stimulus;Structure;Synapses;Synaptic plasticity;Synaptic Transmission;Testing;two-photon;Visual;visual dysfunction;Visual Motion;voltage

PROJECT_TITLE: Dynamic interactions between synaptic and intrinsic properties of starburst amacrine cells for robust motion detection

STUDY_SECTION: BDE

STUDY_SECTION_NAME: Biology and Development of the Eye Study Section[BDE]


ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: NARRATIVE Skilled movement is believed to emerge from the learned dynamical patterns of neural activity in motor control brain regions. However, movement related activity in the cerebellar neurons is best understood at the cellular level. Therefore, we will test the hypothesis that cerebellar Purkinje cells also employ a population code that synergizes spike rate modulation and synchronous firing to produce robust disinhibition of recipient neurons in the cerebellar nuclei leading to kinematic alterations of learned, dexterous motor behaviors.

PI_NAMEs: CHRISTIE, JASON M;PERSON, ABIGAIL L (contact)

PROGRAM_OFFICER_NAME: CHEN, DAOFEN

PROJECT_TERMS: Acute;Affect;Animals;Architecture;Behavior;Behavior Control;Behavioral;Brain;Brain region;Cell Nucleus;Cells;Cerebellar Cortex;Cerebellar Diseases;Cerebellar Nuclei;Cerebellum;Closure by clamp;Code;Communication;Disinhibition;Dysmetria;Fiber;flexibility;Functional disorder;Future;Goals;granule cell;improved;Interneurons;kinematics;Knowledge;learned behavior;Learning;learning engagement;Limb structure;Location;Measures;Mediating;Modeling;Molecular;Motor;motor behavior;motor control;Motor Cortex;motor learning;Motor output;Movement;Mus;Nature;neural;neural correlate;neural patterning;neuronal excitability;Neurons;Nuclear;optogenetics;Output;Pattern;Performance;Physiological;Population;Population Dynamics;Process;Property;Public Health;Purkinje Cells;response;Signal Transduction;skills;Slice;Structure;Synapses;synergism;targeted treatment;Task Performances;Testing;Time;transmission process;Work

PROJECT_TITLE: Circuit mechanisms of cerebellar control of reaching movements

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 ICN-S (02)]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Neurosciences

ORG_CITY: Newark

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: Project Narrative Studies on the development, regulation, and maintenance of neural circuits yield insights into mechanisms underlying various neurological disorders. The multidisciplinary training efforts of our faculty working with undergraduate student participants will focus on neurological disorders including Alzheimer's, Parkinson's, autism, multiple sclerosis, traumatic brain injury, spinal cord injury, sensory loss, epilepsy, and stroke, which are of clear relevance to NINDS.

PI_NAMEs: ALDER, JANET ;RASIN, MLADEN ROKO ;ZHANG, HUAYE  (contact)

PROJECT_TERMS: Academia;Admission activity;Alder plant;Alzheimer's Disease;autism spectrum disorder;biological research;Black race;career;Career Choice;career development;career networking;Clinical;design;Development;disadvantaged background;Doctor of Philosophy;doctoral student;economic disparity;Educational Activities;Epilepsy;Etiology;Event;experience;Faculty;faculty mentor;Feedback;field trip;Funding;Future;General Population;Genetic Processes;Genomics;Goals;graduate school;graduate student;hands on research;Hispanic;improved;Infrastructure;insight;Instagram;Interdisciplinary Study;interest;Knowledge;LinkedIn;Maintenance;Manuscripts;meetings;member;Mental disability;Mentors;Molecular;multidisciplinary;Multiple Sclerosis;National Institute of Mental Health;National Institute of Neurological Disorders and Stroke;Native Americans;Nervous System;Nervous System Disorder;neural circuit;Neurosciences;Oral;Outcome;Pacific Islander;Paper;Parkinson Disease;Participant;Pathogenesis;Pharmacologic Substance;physically handicapped;Physicians;Postdoctoral Fellow;programs;prospective;Reading;recruit;Regulation;Reproducibility;Research;research faculty;Research Project Grants;responsible research conduct;Scientist;Sensory;social disparities;spinal cord and brain injury;Statistical Data Interpretation;Stroke;Students;summer research;Supervision;symposium;Training;Traumatic Brain Injury;undergraduate research experience;undergraduate student;Underrepresented Minority;underrepresented minority student;United States National Institutes of Health;Universities;Work;Writing

PROJECT_TITLE: Summer Undergraduate Research Program (NEUROSURP) in Neuroscience


ORG_CITY: GAINESVILLE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: PROJECT NARRATIVE Early detection of HIV using a self-testing kit at home can save lives of millions of HIV-infected patients and their partners by enabling early intervention and treatment options preventing spreading and maturation to AIDS. This project defines a novel approach to detect HIV RNA based on engineered CRISPR/Cas12a system coupled with an automated microfluidic-based device. To make it amenable to the resource-constrained settings, our proposed diagnostic approach will follow the ASSURED (Affordable, Sensitive, Specific, User-friendly, Rapid and robust, Equipment-free and Deliverable to end-users) criteria as recommended by the World Health Organization.

PI_NAMEs: JAIN, PIYUSH K (contact)

PROGRAM_OFFICER_NAME: LAWRENCE, DIANE M

PROJECT_TERMS: 2019-nCoV;Acquired Immunodeficiency Syndrome;alcohol research;Antibodies;Binding;Biological Assay;Blood specimen;Blood Volume;Cells;Cellular Phone;Cessation of life;Clinic;Clinical;Clinical assessments;Clustered Regularly Interspaced Short Palindromic Repeats;Cohort Studies;cost;Coupled;COVID-19 detection;Cytolysis;Data;Detection;detection limit;detection platform;Development;Devices;Diagnostic;diagnostic platform;Diagnostic Reagent Kits;diagnostic strategy;Disease Outbreaks;DNA;DNA amplification;Early Diagnosis;Early Intervention;Early treatment;Engineering;Enrollment;env Genes;Equipment;experience;Eye;Feedback;Fingers;Fluorescence;Fluorescence Resonance Energy Transfer;Freeze Drying;Genes;Goals;Hepatitis C virus;high reward;high risk;HIV;HIV-1;Home;Human immunodeficiency virus test;improved;Infection;innovation;instrumentation;Intervention;lateral flow assay;magnetic beads;Magnetism;Methods;Microfluidic Microchips;Microfluidics;Monitor;mortality risk;novel strategies;nuclease;nucleic acid detection;Nucleic Acids;Orthologous Gene;Paper;Participant;Patient Compliance;Patients;Performance;Persons;Phase;Pilot Projects;Plasma;point of care;point-of-care diagnostics;Preparation;prevent;Reaction;Reagent;Recommendation;recruit;Reporter;Reporting;research clinical testing;Resource-limited setting;Resources;Risk Reduction;RNA;Saliva;Sampling;self testing;Sensitivity and Specificity;Serum;Services;Specificity;Surveys;System;Technology;Temperature;Testing;thermophilic organism;transmission process;usability;user-friendly;validation studies;viral RNA;World Health Organization

PROJECT_TITLE: A rapid CRISPR-based self-testing platform for early detection of HIV

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 JBS-A (S1)]


NIH_SPENDING_CATS: Biotechnology;Drug Abuse (NIDA only);Gene Therapy;Genetics;HIV/AIDS;Human Fetal Tissue;Immunotherapy;Infectious Diseases;Prevention;Substance Misuse

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: Project Narrative  Adeno associated virus (AAV) vectors can be used to deliver broadly neutralizing antibodies (bNAbs) against human immunodeficiency virus (HIV) to permanently suppress virus in animal models, making them promising candidates for HIV prevention and therapy. In this proposal, we will determine which aspects of AAV vectors cause the development of immune responses against the delivered bNAbs and engineer new AAV vectors to avoid this. This work will enhance our understanding of the mechanisms vector immunogenicity and contribute to the development of future HIV cure strategies.

PI_NAMEs: BALAZS, ALEJANDRO BENJAMIN (contact)

PROGRAM_OFFICER_NAME: POON, BETTY

PROJECT_TERMS: Activities of Daily Living;adeno-associated viral vector;Advanced Development;AIDS prevention;Amino Acid Sequence;Animal Model;Animals;Antibodies;Antibody Response;Antigen-Presenting Cells;Automobile Driving;Biodistribution;Capsid;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;cellular transduction;Cellular Tropism;Clinical Research;Clinical Trials;cytokine;Data;design;Development;Directed Molecular Evolution;Disease remission;Doctor of Philosophy;Dose;Elements;Engineering;Engraftment;Exhibits;experimental study;Future;Gene Expression;Gene Transfer;Genetic Transcription;Grant;HIV;HIV Antibodies;HIV Infections;HIV therapy;Human;human subject;humanized mouse;Immune;Immune response;Immune signaling;Immune system;immunoengineering;immunogenicity;Immunologic Stimulation;Immunologics;Immunology;immunoprophylaxis;improved;in vivo;in vivo Model;Individual;Intramuscular;Intramuscular Injections;Knockout Mice;Libraries;Link;Macaca;Measures;Mediating;medical schools;Modeling;multimodality;Mus;Muscle;neutralizing antibody;next generation;nonhuman primate;novel;Outcome;Participant;participant enrollment;Patients;Pattern;Pharmaceutical Preparations;Phase;phase 1 study;Principal Investigator;professor;programs;receptor;Research;Resolution;Role;Safety;Satellite Viruses;Serotyping;Signal Pathway;simian human immunodeficiency virus;single-cell RNA sequencing;Testing;Tissues;transduction efficiency;transgene expression;Transgenes;Tropism;vector;Viral;Virus;Work

PROJECT_TITLE: Eliminating the Immunogenicity of AAV Vectored HIV Antibody Delivery

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 BJM-A (S1)]


ORG_NAME: VANDERBILT UNIVERSITY

PHR: Project Narrative  Critical for maintaining blood glucose homeostasis, G6PC1 activity lies in the pathological crosshairs of diabetes and glycogen storage disease type 1a. Our methodological approach seeks to define the mechanistic underpinnings of G6PC1 activity as well as the consequences of disease-associated mutations on the functional cycle and enzyme stability. Completion of the proposed aims will lead to the most comprehensive description of G6PC1 functional dynamics to date, which will inform the rational design of targeted therapeutic strategies that alleviate the complications arising from metabolic disease.

PI_NAMEs: CLAXTON, DEREK P (contact)

PROGRAM_OFFICER_NAME: TAYLOR, VERONICA

PROJECT_TERMS: Active Sites;Address;Algorithms;Architecture;Automobile Driving;Benchmarking;Binding;Biochemical;Biological Assay;Biology;biophysical analysis;biophysical techniques;Biophysics;Blood Glucose;blood glucose regulation;Carrier Proteins;Catalysis;Catalytic Domain;Cell membrane;Cholesterol;Code;computational pipelines;computational suite;Computational Technique;computer framework;Computer Models;conformer;Cryoelectron Microscopy;Data Set;Detergents;Diabetes Mellitus;Disease;DNA Sequence Alteration;Drug Design;drug discovery;electron density;Electrons;Endoplasmic Reticulum;Engineering;Enzymatic Biochemistry;enzyme activity;Enzyme Stability;Enzymes;Equilibrium;Experimental Designs;experimental study;Failure;Fasting;Future;Gatekeeping;glucose metabolism;glucose production;glucose-6-phosphatase;Glucose-6-Phosphate;Glucosephosphates;Glycogen Storage Disease;Goals;Hepatic;holistic approach;Hot Spot;Hydrolysis;Hypoglycemia;Impairment;improved;in silico;In Vitro;inorganic phosphate;Integral Membrane Protein;Kinetics;Knowledge;Laboratories;Link;Lipid Bilayers;Lipid Binding;Liver;Mediating;member;Membrane;Membrane Proteins;Metabolic Diseases;Methodology;Micelles;Missense Mutation;Modeling;Molecular;Molecular Biology;Molecular Conformation;molecular dynamics;molecular modeling;mouse model;Mus;Mutagenesis;mutant;Mutation;novel;Orthologous Gene;particle;Pathologic;Pathology;Pattern;Phosphatidate Phosphatase;Phosphoric Monoester Hydrolases;Physiological;prediction algorithm;predictive modeling;programs;Protein Isoforms;Publishing;rational design;Rationalization;Request for Proposals;Research;Resolution;Rest;restraint;Role;screening;spectroscopic survey;Spectrum Analysis;Spin Labels;structural biology;Structure;targeted treatment;Testing;therapeutic target;Thermodynamics;three-dimensional modeling;Time;tool;type I and type II diabetes;Variant;Work

PROJECT_TITLE: Structure and Mechanism of the Glucose-6-Phosphatase Catalytic Subunit 1

STUDY_SECTION: MSFA

STUDY_SECTION_NAME: Macromolecular Structure and Function A Study Section[MSFA]


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

NIH_SPENDING_CATS: Clinical Research;Genetics;Kidney Disease;Precision Medicine

ORG_CITY: ROCHESTER

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: Project Narrative The common deletion variant of the GSTM1 gene has been associated with kidney disease progression in several human cohorts. Deletion of the gene augments kidney disease in mouse models. The current proposal will investigate the transsulfuration metabolic pathway that governs the effect of GSTM1 deletion in both mice and humans, and has therapeutic implications in an individualized and precision medicine approach.

PI_NAMEs: LE, THU H. (contact)

PROGRAM_OFFICER_NAME: PARSA, AFSHIN

PROJECT_TERMS: African American;Alleles;American;Angiotensin II;antioxidant enzyme;Apolipoproteins;Atherosclerosis Risk in Communities;Biological Markers;Biosensor;Blood Vessels;Bone Marrow;cadherin 5;cancer risk;Cardiovascular Diseases;CCL2 gene;Cell Physiology;Cells;Cellular Metabolic Process;Cessation of life;Child;Chronic Kidney Failure;Classification;Clinical;cohort;Cohort Studies;comparison control;Creatinine;CXCL1 gene;Cystathionine;Cysteine;Data;Data Correlations;Dialysis procedure;Diet;dietary;Disease;disease model;Disease Progression;Dose;double-blind placebo controlled trial;End stage renal failure;Endothelium;enzyme deficiency;Enzymes;Equilibrium;Event;Gene Deletion;Genes;Genotype;Glutathione S Transferase A;glutathione S-transferase M1;high risk;Homocysteine;Human;Hydrogen Sulfide;Hypertension;Immune;individualized medicine;Inflammation;inhibitor;Injury;Isoprostanes;Kidney;Kidney Diseases;Knockout Mice;LoxP-flanked allele;Lyase;Malignant Neoplasms;Metabolic;Metabolic Pathway;Methionine;Modeling;mouse model;Mus;MYH11 gene;neutrophil;novel;Nuclear;nuclear factor-erythroid 2;Outcome;Oxidative Stress;p65;Participant;Pathway interactions;Patient Recruitments;Patients;Phase;Phenotype;Phosphoenolpyruvate Carboxylase;Plasma;Population;precision medicine;Production;Randomized;Reactive Oxygen Species;Regulation;renal epithelium;Renal tubule structure;Reporting;response;risk variant;Role;segregation;Serum;Signal Transduction;Site;Smooth Muscle Myocytes;Specificity;Sulfate;Sulforaphane;Survival Analysis;Testing;Therapeutic;therapeutic target;Transplantation;urinary;Validation;Variant;Vascular Endothelium;Vascular Smooth Muscle;Wild Type Mouse

PROJECT_TITLE: GSTM1-Transsulfuration metabolic axis in kidney disease: therapeutic target in precision medicine

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Aging;Arthritis;Behavioral and Social Science;Chronic Pain;Clinical Research;Comparative Effectiveness Research;Cost Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pain Research;Physical Activity;Prevention;Racial and Ethnic Minority Health Research

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: The overall goal of this proposal is to plan and prepare a well-powered randomized optimization trial evaluating the initiation and maintenance of physical activity (PA) through an enhanced Camine con Gusto, an evidence- based walking program for Spanish speaking adults with arthritis. The developed trial will reduce PA disparities among Latinos with arthritis, an understudied population in arthritis research.

PI_NAMEs: CALLAHAN, LEIGH FLEMING (contact);SOTO, SANDRA HYATT

PROGRAM_OFFICER_NAME: ZHENG, XINCHENG

PROJECT_TERMS: Activities of Daily Living;Adherence;Adult;Affect;Analgesics;Arthralgia;arthritic pain;Arthritis;Behavior;Behavior Therapy;Behavioral;Blinded;budget impact;Budgets;Clinical Trials;Collection;Communities;community advisory board;Community Health;community organizations;Consent;cost;cost effective;cost effectiveness;cost-effectiveness evaluation;Data;data management;Degenerative polyarthritis;Development;Disparity;Effectiveness of Interventions;Electronic Mail;Enrollment;Ensure;evidence base;exercise intervention;experience;Fatigue;Feedback;Foundations;Fright;Future;Goals;Grant;improved;improved outcome;Individual;Intervention;intervention refinement;Joints;Language;Latino Population;Maintenance;Manuals;Medical;Methods;moderate-to-vigorous physical activity;Monitor;multi-component intervention;multiphase optimization strategy;Nonpharmacologic Therapy;Outcome Measure;pain reduction;Participant;Patient Self-Report;pedometer;Pharmacologic Substance;Physical activity;physical inactivity;Population;premature;primary outcome;Procedures;Professional Organizations;programs;Protocols documentation;Randomized;Recommendation;recruit;Research;Research Assistant;Resources;Safety;secondary outcome;Self Efficacy;Self Management;sleep quality;Spanish;Statistical Data Interpretation;Structure;Symptoms;Testing;theories;therapy design;timeline;Training;treatment disparity;United States;Walking;walking program;web portal;Work

PROJECT_TITLE: Evaluating the essential components needed for a physical activity initiation and maintenance intervention to improve physical activity and arthritis pain and symptoms in Latinos with arthritis

STUDY_SECTION_NAME: Special Emphasis Panel[ZAR1 FY (M1)]


NIH_SPENDING_CATS: Biomedical Imaging;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Rare Diseases

ORG_CITY: MADISON

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Relevance: The goal of this project is to develop radiomic-image (Rad-I) maps of spatial tumor extent on clinical MRI scans and histopathologically validate their efficacy in non-invasively distinguishing (a) viable/infiltrative tumor from vasogenic edema and (b) tumor recurrence from treatment-related effects, in glioblastoma tumors. Our proposed multi-institutional validation will demonstrate the clinical utility of Rad-I maps as a noninvasive alternative to stereotactic biopsies in identifying the tumor extent, ultimately paving the way for tailored surgical and post-treatment response management, thereby improving long-term outcomes in patients with glioblastoma.

PI_NAMEs: AHLUWALIA, MANMEET ;TIWARI, PALLAVI  (contact)

PROGRAM_OFFICER_NAME: ZHANG, HUIMING

PROJECT_TERMS: 3-Dimensional;Address;Adoption;Aftercare;Anatomy;Appearance;Biopsy;Brain Neoplasms;Cellularity;Characteristics;chemoradiation;Clinical;clinical decision-making;clinical research site;Clinical Trials;Clinical Trials Design;clinically actionable;cohort;Complex;cost effective;Development;Diagnosis;Disease;Edema;Enhancing Lesion;Ensure;Entropy;Feedback;Glioblastoma;Goals;Graph;Heterogeneity;Histologic;Histology;Histopathology;Image;Imaging Device;improved;in vivo;Infiltration;innovation;Institution;Left;Lesion;Letters;Magnetic Resonance Imaging;Maps;Measurement;Measures;Molecular;Morphology;MRI Scans;multidisciplinary;neoplastic cell;Neurosurgeon;novel;Operative Surgical Procedures;Organizational Change;Outcome;Pathology;Pathway interactions;Patients;Perfusion;Play;prospective;Radiation;Radiology Specialty;radiomics;Recurrence;Recurrent tumor;Reporting;Reproducibility;Resected;Role;Sampling;Sampling Errors;Scanning;Site;standard of care;success;Surveys;Tissue Sample;Tissues;tool;treatment effect;treatment response;tumor;tumor microenvironment;Validation;vasogenic edema

PROJECT_TITLE: Radiomic spatial maps for identifying viable tumor extent on multi-parametric MRI for Glioblastoma

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Gene Therapy;Genetics;Immunotherapy;Women's Health Research

ORG_CITY: WEST LAFAYETTE

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: PROJECT NARRATIVE The project is relevant to the NIH’s mission and to public health because successful completion of this work will finally unveil the two-decade-long promise of using small RNAs as anti-cancer agents. Here, using a relevant ligand and receptor pair, coupled to an endosomal escape agent and a fully modified miRNA that has increased stability and targeting, we will succeed in generating the first anti-cancer small RNA therapeutic. Indeed, the benefit to cancer therapeutics will be enormous through simply (and finally) including all these essential components into an easily synthesized, all-encompassing agent.

PI_NAMEs: KASINSKI, ANDREA L (contact)

PROGRAM_OFFICER_NAME: KONDAPAKA, SUDHIR B

PROJECT_TERMS: 2019-nCoV;Affinity;anti-cancer;Antineoplastic Agents;Binding;Biodistribution;blood-brain barrier crossing;Breast Cancer Treatment;cancer cell;cancer imaging;Cells;Central Nervous System;Central Nervous System Neoplasms;Circulation;Clinical;Clinical Trials;combinatorial;Complex;cost;Coupled;Cytosol;Data;Dedications;delivery vehicle;dietary;Disease;Dose;Drug Kinetics;Drug Targeting;Endosomes;Excision;FDA approved;folate-binding protein;Folic Acid;Funding;Generations;Goals;Half-Life;Image-Guided Surgery;in vivo;Kinetics;Ligands;Liver;Location;Malignant Neoplasms;Mediating;MicroRNAs;Mission;Modification;Nigericin;Oncology;overexpression;Paclitaxel;PDL1 inhibitors;prevent;programmed cell death ligand 1;Public Health;receptor;receptor mediated endocytosis;RNA;RNA delivery;RNA Interference;RNA vaccine;Small RNA;success;Swelling;synergism;Testing;Therapeutic;Therapeutic Agents;Therapeutic antibodies;therapeutic miRNA;therapeutic RNA;Time;tool;Toxic effect;Treatment-related toxicity;triple-negative invasive breast carcinoma;tumor;United States National Institutes of Health;Work

PROJECT_TITLE: Enhancing miRNA Therapeutics through Vehicle Free Delivery

STUDY_SECTION: ATA

STUDY_SECTION_NAME:
Advancing Therapeutics A Study Section
[ATA]


ORG_CITY: PROVIDENCE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: NARRATIVE Neuroscience is one of the fastest growing areas of biomedical research, with many unanswered questions about the basic mechanism of brain function and how dysfunction at the genetic, cellular, and systemic levels leads to neurological diseases and disorders. All of these areas of research are increasingly incorporating cutting-edge computational research techniques, yet women and other historically underrepresented groups (HUGs) are less common in computational fields. This nine-week summer training program will enhance the research career trajectories of HUG undergraduates through a coordinated set of elements focused on neuroscience research, building computational fluency, and professional skills development.

PI_NAMEs: JONES, STEPHANIE RUGGIANO (contact);RITT, JASON T;WEBSTER, KRISTIN

PROJECT_TERMS: Address;Adopted;Area;Biomedical Research;Brain;career;career preparation;Code;cohort;Collaborations;Communities;computational neuroscience;Computational Science;Computer Architectures;curriculum development;Data Analyses;design;Development;Discipline;Disease;Disparity population;Doctor of Philosophy;Early identification;Education Projects;Educational process of instructing;Educational workshop;Elements;Environment;experience;Exposure to;Faculty;faculty mentor;Functional disorder;Funding;Genetic;Goals;graduate student;Health;help-seeking behavior;Hour;Individual;innovation;Interdisciplinary Study;interest;laboratory experience;Leadership;Learning;lectures;meetings;Mentors;Mentorship;Methods;National Institute of Neurological Disorders and Stroke;Nervous System Disorder;Neurosciences;Neurosciences Research;Participant;Patient Recruitments;peer coaching;Phase;Postdoctoral Fellow;posters;Preparation;Programming Languages;programs;Readiness;Reproducibility;Research;Research Institute;Research Methodology;Research Personnel;Research Project Grants;Research Technics;role model;Scholars Program;Science;Series;skill acquisition;skills;Structure;student mentoring;Students;summer research;symposium;System;teaching assistant;Techniques;tool;Training;Training Programs;undergraduate student;Underrepresented Populations;Underrepresented Students;Universities;Woman;Women's Group;Work

PROJECT_TITLE: Brown University Summer Scholars Program in Computational Brain Science


ORG_CITY: JOHNSON CITY

ORG_DEPT: SURGERY

ORG_NAME: EAST TENNESSEE STATE UNIVERSITY

PHR: Narrative.  In the United States ~750,000 patients/year develop sepsis syndrome. In these patients, the overall mortality rate is 28.6% (~215,000 deaths/year). The proposed studies will provide a mechanistic understanding of a critical role of epigenetic modification of macrophage transcriptional factors and effectors in the development of sepsis. This is a new and novel conceptual work to elucidate how macrophage transcriptional factors and effectors regulate immune function and target these important effectors will improve the survival outcome of sepsis patients.

PI_NAMEs: LI, CHUANFU  (contact)

PROGRAM_OFFICER_NAME: MINNICOZZI, MICHAEL

PROJECT_TERMS: Address;age related;Bacteria;Biological Process;Cell Aging;Cell Cycle Arrest;cellular targeting;Cessation of life;Clinical Data;Data;Death Rate;Development;Disease;Epigenetic Process;Functional disorder;Gene Expression;Gene Expression Regulation;Genetic Transcription;Histones;HMGB1 gene;immune function;Immune response;Immune System Diseases;Immune Targeting;immunoregulation;Impairment;improved;Infection;Inflammatory;inhibitor;Innovative Therapy;Life;Macrophage;Mediating;Mediator;Modification;Morbidity - disease rate;mortality;Mus;non-histone protein;novel;Nuclear Translocation;Opportunistic Infections;Organ;p65;Pathway interactions;Patients;Phagocytes;Phagocytosis;Phenotype;Play;Pneumonia;Predisposition;Production;Reporting;response;Risk;Role;senescence;senescence associated secretory phenotype;Sepsis;Sepsis Syndrome;septic;septic patients;Severities;survival outcome;Survivors;transcription factor;transcriptome sequencing;United States;Work

PROJECT_TITLE: Novel Role of Lactate in Sepsis Impaired Immune Function

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


ED_INST_TYPE: UNIVERSITY-WIDE

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

ORG_STATE: NY

PHR: Despite years of effective suppressive antiretroviral therapy (ART), latent HIV-infected cells can persist in people with HIV (PWH) and reintroduce disseminated HIV infection after cessation of ART, preventing the functional cure of PWH. The anti-HIV immune response in most PWH is inadequate to effectively eliminate reactivated latent infected cells, necessitating the development of strategies to boost the anti-HIV immune response to enable it to clear the reservoir after reactivation. We propose to develop cell-specific lentivector particles that can be injected into PWH to direct in vivo generation of T cells expressing anti-HIV therapeutic genes (CAR- chimeric antigen receptor and/or bNAb-broadly neutralizing antibodies, respectively) in PWH to provide them with sustained and robust anti-HIV CAR-T cell and antibody responses which will enable them to achieve sustained ART-free remission.

PI_NAMEs: GOLDSTEIN, HARRIS  (contact)

PROJECT_TERMS: Adverse effects;Animal Model;Antibody Response;antiretroviral therapy;Binding;Brain;CD3 Antigens;CD4 Positive T Lymphocytes;Cell secretion;Cells;cellular transduction;chimeric antigen receptor;chimeric antigen receptor T cells;Clinical Trials;Collaborations;Complex;cytokine;Cytomegalovirus;design;design and construction;Development;Disease remission;Distal;engineered T cells;Engineering;Engraftment;Epitopes;exosome;FDA approved;Gene Delivery;gene-targeted therapy;Generations;Genes;Goals;Heart Diseases;HIV;HIV Envelope Protein gp120;HIV Infections;humanized mouse;IgG1;IL7 gene;Immune;Immune response;Immunologic Surveillance;In Vitro;in vivo;Incidence;Infection;Infrastructure;Infusion procedures;inhibitor;Injectable;innovation;Interleukin-15;interleukin-21;Interruption;Lentivirus Vector;Light;Link;liver injury;Logistics;manufacture;Membrane;mouse model;Mus;neuropsychiatry;neutralizing antibody;next generation;novel;particle;Patients;Peptide/MHC Complex;Peptides;Peripheral Blood Mononuclear Cell;Persons;Phenotype;pre-clinical;preclinical study;prevent;Recurrence;Research;Resistance;Resource-limited setting;Safety;side effect;Signal Transduction;Surface;synergism;T cell therapy;T memory cell;T-Cell Activation;T-Lymphocyte;Technology;Therapeutic;therapeutic gene;Transforming Growth Factor beta;Treatment Efficacy;Variant;vector;Vertebral column;Vesicular stomatitis Indiana virus;Vesiculovirus;Viral;Viremia;Virus

PROJECT_TITLE: Developing and evaluating cell-specific lentivectors capable of selective in vivo generation of anti-HIV T cells to cure HIV