NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Infectious Diseases;Natural Products

ORG_CITY: ST LOUIS

ORG_NAME: INTACT GENOMICS, INC.

ORG_STATE: MO

PHR: PROJECT NARRATIVE Unfortunately, we are losing the fight against both infectious and chronic diseases due to ongoing pandemics, the alarming increase in the number of multi-drug resistant microbes, and our inability to find drug leads with novel mechanisms of action. To assist in the ongoing search for new drugs and drug leads, this proposed research further develops Fungal Artificial Chromosomes (FACs) into an advanced FAC-NGS-AI technology and tool for drug discovery that allows access to the majority of fungal biosynthetic gene clusters for high yields of natural products from environment filamentous fungi. For this Phase II proposal, our functional metagenomic approach will be used to synthesize, identify and characterize novel antibiotics, and produce them in high yield from dedicated fungal FAC-transformants to aid in the fight against drug-resistant microorganisms.

PI_NAMEs: WU, CHENGCANG CHARLES (contact)

PROGRAM_OFFICER_NAME: LIU, BAOYING

PROJECT_TERMS: Address;Anabolism;anti-fungal agents;Anti-Infective Agents;Anti-Inflammatory Agents;Antibiotics;antimicrobial;Applications Grants;Artificial Chromosomes;Artificial Intelligence;Bacterial Artificial Chromosomes;Bioinformatics;bioinformatics pipeline;Biological Assay;Businesses;Chemicals;Chronic Disease;clinical development;Coculture Techniques;Communicable Diseases;cost;Coupled;COVID-19 pandemic;Crude Extracts;Data;Dedications;Development;Dissection;DNA;drug discovery;drug resistant microorganism;Economics;Engineering;Environment;Fermentation;fighting;Fungal natural products;fungus;Gene Cluster;Genetic Variation;Genomics;Goals;High Pressure Liquid Chromatography;improved;in silico;Infectious disease threat;infectious disease treatment;innovation;Length;Libraries;Metagenomics;methicillin resistant Staphylococcus aureus;Methodology;microbial;Molds;Montana;Multi-Drug Resistance;Natural Compound;Natural product discovery;Natural Products;next generation sequencing;novel;novel antibiotic class;novel therapeutics;Nuclear Magnetic Resonance;pandemic disease;Pathway interactions;Pharmaceutical Preparations;Phase;phase 2 study;Preparation;Production;Proliferating;Public Health;Publishing;Research;research and development;Research Proposals;Science;secondary metabolite;Services;Small Business Innovation Research Grant;social;Source;Structure;Technology;Therapeutic;tool;Universities;vector;virtual;Work;Workplace

PROJECT_TITLE: Rapid dissection of the biosynthesis of antiMRSA antibiotics produced in co-culture by extremophilic fungi through the development of Fungal Artificial Chromosomes


ADMINISTERING_IC: AA

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Clinical Research;HIV/AIDS;Infectious Diseases;Prevention;Substance Misuse

ORG_CITY: PROVIDENCE

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PI_NAMEs: KAHLER, CHRISTOPHER W. (contact)

PROJECT_TERMS: Address;Advisory Committees;AIDS prevention;Alcohol consumption;alcohol intervention;alcohol misuse;alcohol research;Alcohols;biobehavior;Boston;Caring;Collaborations;Communication;comorbidity;Cost efficiency;Ensure;Evaluation;Evolution;Extramural Activities;Financial Support;Fostering;Funding;Goals;Grant;high risk;high risk population;HIV;HIV Infections;HIV/AIDS;implementation framework;implementation intervention;Incidence;innovation;insight;interdisciplinary approach;International;Intervention;Leadership;Mentors;Mission;Monitor;operation;organizational structure;Outcomes Research;Participant;Persons;Phase;Pilot Projects;Policies;Postdoctoral Fellow;Procedures;programs;Research;Research Methodology;Research Personnel;Resources;Role;Science;Scientist;sound;Structure;Teleconferences;Training;United States National Institutes of Health;Universities;Viral;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Bioengineering;Clinical Research;Dissemination and Implementation Research;HIV/AIDS;Health Services;Infectious Diseases;Networking and Information Technology R&D (NITRD);Prevention;Substance Misuse;Telehealth

PI_NAMEs: LIU, TAO  (contact)

PROJECT_TERMS: Acceleration;addiction;Address;Adopted;AIDS prevention;Alcohol consumption;alcohol intervention;alcohol misuse;alcohol research;alcohol screening;Alcohols;archive data;archived data;Archives;Area;Biometry;Caring;Collaborations;Collection;Consultations;cost;Data Analyses;data archive;Data Collection;data harmonization;data management;Data Management Resources;Data Set;design;digital;digital health;Documentation;Education;Effectiveness;Ensure;Epidemic;experience;Faculty;follow-up;Goals;Health Sciences;Healthcare;HIV;home test;Human Resources;implementation framework;implementation science;implementation strategy;Improve Access;improved;Individual;Information Systems;innovation;instrument;Intervention;intervention program;Lead;Manuscripts;Measures;Methods;Monitor;National Institute on Alcohol Abuse and Alcoholism;novel;Online Systems;Participant;patient home care;Pilot Projects;Population;practice setting;programs;Public Health;Recording of previous events;Reproducibility;Research;Research Design;Research Methodology;Research Personnel;Resource Sharing;Resources;Retrieval;Risk;Sales;screening;Source;Statistical Data Interpretation;Statistical Methods;Strategic Planning;Surveys;synergism;System;Tablets;Technology;technology intervention;telehealth;Text Messaging;tool;Training;Training and Education;Translating;Translations;United States National Institutes of Health;Universities;Videoconferencing;web-based intervention;Work

PROJECT_TITLE: Research Methods Core


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Prevention;Sexually Transmitted Infections;Social Determinants of Health;Substance Misuse;Telehealth

PI_NAMEs: WRAY, TYLER BLAKE (contact)

PROJECT_TERMS: Address;Adopted;Adoption;African American;AIDS prevention;Alcohol abuse;Alcohol consumption;alcohol misuse;alcohol related problem;alcohol research;Alcoholic beverage heavy drinker;Alcohols;Anal Sex;Area;Baltimore;behavior change;binge drinking;brief intervention;brief motivational intervention;Caring;Chlamydia;Cities;Clinic;Communities;comparison control;condomless anal sex;Counseling;Data;design;Diagnostic Reagent Kits;District of Columbia;drinking;Effectiveness;Ensure;Event;evidence base;Focus Groups;follow-up;Future;Genitalia;Goals;Guidelines;Heavy Drinking;high risk;high risk men;Hispanic;HIV;HIV diagnosis;HIV Infections;HIV risk;HIV Seronegativity;Home;Hour;Human immunodeficiency virus test;Hybrids;implementation outcomes;implementation questions;implementation/effectiveness;improved;Incidence;Infection;infection risk;innovation;Intervention;Interview;Latino;Link;Los Angeles;men who have sex with men;Methods;Modeling;mortality;motivational enhancement therapy;Online Systems;outreach program;Participant;pharyngeal gonorrhea;phosphatidylethanol;Population;Populations at Risk;pre-exposure prophylaxis;prevent;Prevention;Prevention approach;Prevention program;programs;Randomized;Randomized, Controlled Trials;Recommendation;recruit;Rectum;Reporting;response;Risk;Risk Factors;Risk Reduction;sample collection;satisfaction;screening;self testing;Services;sex;Sex Behavior;sex risk;Sexual Partners;sexual risk behavior;Sexually Transmitted Diseases;Site;Surveys;Syphilis;Testing;theories;Time;tool;transmission process;United States;Universities;Unsafe Sex;uptake;Viral;virtual;web app;web-based intervention;Work

PROJECT_TITLE: Brief, web-based intervention to reduce heavy drinking and encourage prevention among high-risk men completing HIV/STI self-testing


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Bioengineering;Dental, Oral, and Craniofacial Disease

ORG_CITY: PITTSBURGH

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: NARRATIVE In this proposal the University of Pittsburgh School of Dental Medicine will establish a new Research Training Program aimed at preparing the next generation of Craniofacial/Dental focused scientists. Major research foci at Pitt Dental are Craniofacial/Dental Genetics and Craniofacial/Dental Tissue Regeneration as well as translational research. Trainees will be included at both the pre-doctoral and post-doctoral levels.

PI_NAMEs: SFEIR, CHARLES  (contact)

PROGRAM_OFFICER_NAME: MCGUIRL, MICHELE

PROJECT_TERMS: Address;Admission activity;Artificial Intelligence;Award;Biomedical Engineering;Caliber;Clinic;Clinical Research;Clinical Sciences;craniofacial;Data Science;Dental;Dental Research;Dental Schools;Doctor of Philosophy;doctoral student;Ecosystem;education research;Engineering;Enrollment;experience;Faculty;Funding;Generations;Genetic Medicine;Goals;graduate school;Health Sciences;Human Genetics;Human Resources;Individual;Institution;International;Investments;Journals;Laboratories;Leadership;Medicine;Mentors;Methods;National Institute of Dental and Craniofacial Research;Oral;post-doctoral training;Postdoctoral Fellow;programs;Prosthodontic specialty;Public Health Schools;Regenerative Medicine;Reproducibility;Research;research faculty;Resources;responsible research conduct;Schools;Science;Scientist;Series;Students;symposium;Training;Training Programs;Translational Research;United States National Institutes of Health;Universities;University resources;Work

PROJECT_TITLE: Pittsburgh Craniofacial Sciences Training Program


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;HIV/AIDS;Health Services;Infectious Diseases;Networking and Information Technology R&D (NITRD);Prevention;Primary Health Care;Substance Misuse;Telehealth

PROJECT_TERMS: Address;Adherence;Administrator;Aging;AIDS prevention;Alcohol consumption;alcohol effect;alcohol intervention;alcohol misuse;alcohol research;Alcohols;antiretroviral therapy;Behavior Therapy;Belief;Biochemical;Biological Markers;brief intervention;Cardiovascular Diseases;care providers;Caring;Characteristics;cigarette smoking;Clinical;Cohort Studies;comorbidity;condoms;Consumption;Counseling;Data;drinking;Ecosystem;Effectiveness;effectiveness-implementation randomized trial;Enrollment;Ethnic Origin;Evaluation;Federally Qualified Health Center;Feedback;follow-up;Frequencies;Functional disorder;Future;Gender Identity;Geography;Health;Health behavior;Heavy Drinking;HIV;hybrid type 1 trial;Hybrids;implementation evaluation;implementation measures;implementation outcomes;Implementation readiness;improved;indexing;Individual;Intervention;Interview;live text;Liver;Malignant Neoplasms;Measures;motivational enhancement therapy;Neighborhood Health Center;Neurocognitive;Outcome;Participant;Patient Self-Report;Patients;Persons;phosphatidylethanol;Physiological;Population Characteristics;practice setting;Proctor framework;Professional counselor;Protocols documentation;Provider;psychiatric comorbidity;Race;Randomized;Randomized, Controlled Trials;recruit;reduced alcohol use;Reporting;Resources;scale up;secondary outcome;Services;Severities;sexual identity;Specialist;substance use;Surveys;sustainability framework;systemic inflammatory response;telecoaching;telehealth;Telephone;Testing;Text Messaging;therapy adherence;Training;treatment as usual;Universities;Unsafe Sex;Veterans;video coaching;Videoconferencing;Viral;Viral Load result;Work

PROJECT_TITLE: Using Telehealth to Address Alcohol Misuse in HIV Care


ADMINISTERING_IC: HG

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human

ORG_CITY: CHICAGO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: Narrative We propose to continue to develop, and freely share with the community, panels of matched induced pluripotent stem cell (iPSCs) and established organoids, from humans and chimpanzees as a new transformative model system for comparative functional genomic studies in primates.

PI_NAMEs: GILAD, YOAV  (contact)

PROGRAM_OFFICER_NAME: WETTERSTRAND, KRIS A

PROJECT_TERMS: Address;Adult;Affect;ATAC-seq;Autopsy;Biocompatible Materials;Biological Assay;Biological Models;Cardiac;Catalogs;Cell Differentiation process;Cell Line;cell type;Cells;Chromatin;clinically relevant;Collection;Communities;comparative;comparative genomics;Comparative Study;Complex;Data;Data Set;Development;differential expression;differentiation protocol;Disease;Embryoid bodies;Ethics;experience;Fibroblasts;Foundations;Freezing;functional genomics;Future;Gene Expression;Gene Expression Regulation;Genes;genetic architecture;Human;human induced pluripotent stem cells;Individual;induced pluripotent stem cell;insight;Letters;lymphoblastoid cell line;Maps;Mesenchymal;Molecular;Mutation;nonhuman tissue;Organoids;Pan Genus;Phenotype;Pilot Projects;Pongidae;Population;Primates;Process;Property;Research;Research Personnel;Resources;response;Risk;Sampling;Series;single-cell RNA sequencing;Tissue Sample;Tissues;tool;trait;transcriptome sequencing;virtual

PROJECT_TITLE: Development of iPSCs for comparative genomics in primates

STUDY_SECTION: GVE

STUDY_SECTION_NAME: Genetic Variation and Evolution Study Section[GVE]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Dissemination and Implementation Research;HIV/AIDS;Health Services;Infectious Diseases;Prevention;Screening and Brief Intervention for Substance Misuse;Substance Misuse

PI_NAMEs: BECKER, SARA  (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Adherence;AIDS prevention;Alcohol consumption;alcohol effect;alcohol misuse;alcohol research;alcohol use disorder;Alcohols;antiretroviral therapy;Attitude;Automobile Driving;Behavioral;Biological;care systems;Caring;CD4 Positive T Lymphocytes;Charge;Code;Communities;Consultations;Country;Data;Dedications;Development;Disease;effective therapy;Effectiveness;effectiveness evaluation;effectiveness testing;Emergency Situation;Ensure;Epidemic;Evaluation;evidence base;experience;Funding;Goals;Government;Health;Health Professional;health service use;Heavy Drinking;HIV;HIV/AIDS;immune function;implementation outcomes;implementation science;improved;Individual;integrated care;Intervention;Knowledge;Link;low and middle-income countries;Manuals;Measures;Mental disorders;Mental Health;Meta-Analysis;Modeling;Needs Assessment;novel;Outcome;Outcome Measure;pandemic disease;Pathway interactions;Patients;Performance;Persons;Phase;Policies;Policy Maker;Population;Prevalence;prevent;Principal Investigator;programs;Provider;provider factors;Psychiatrist;Psychologist;Quality of life;Reporting;Research;response;Review Literature;Risk;satisfaction;screening, brief intervention, referral, and treatment;Self Efficacy;Services;Site;Social Development;Social Workers;South Africa;Specialist;Stream;System;theories;tool;Trainers Training;Training;transmission process;treatment adherence;treatment organization;United States Substance Abuse and Mental Health Services Administration;Universities;Unsafe Sex;uptake;Virus Replication

PROJECT_TITLE: Advancing Integrated Alcohol-HIV Training of Frontline Providers in a Global Priority Setting


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Regenerative Medicine

ORG_CITY: HOUSTON

ORG_DEPT: PHYSIOLOGY

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: Project Narrative The Hippo-signaling pathway (HSP), a kinase cascade, inhibits nuclear localization and transcriptional activity of YAP, a transcription co-factor via post-translational modifications. Disruption of the HSP 1) reverses established ischemic cardiomyopathy and heart failure and 2) improves heart function in mouse and pig cardiomyocytes due to increased nuclear YAP and activation of YAP target genes. We will explore the mechanism(s) through which YAP Lysine acetylation and phosphorylation regulates heart regeneration, and how these mechanisms can be leveraged in HF therapies.

PI_NAMEs: MARTIN, JAMES F (contact)

PROGRAM_OFFICER_NAME: SHI, YANG

PROJECT_TERMS: Acetylation;Acetyltransferase;Adult;Alleles;Binding;Cardiac Myocytes;cardiac regeneration;Cardiomyopathies;Cell Cycle;Cell Nucleus;Characteristics;Clinical;cofactor;Complex;conditional knockout;Cues;Cytoplasm;Cytoskeleton;Data;Deacetylase;Deacetylation;Development;Disease;Dystrophin;Environment;Environmental Risk Factor;Family;Family suidae;Fibrosis;Gene Expression;gene therapy;Genes;Genetic Transcription;Genomics;Glycolysis;Glycoproteins;Goals;Heart failure;heart function;Homeostasis;Hypoxia;Immunoprecipitation;improved;Inflammation;innovation;insight;ischemic cardiomyopathy;Knock-in;Label;Lysine;Mass Spectrum Analysis;Mediating;Metabolic;Metabolism;Methods;Microfilaments;Microtubule Stabilization;Mitochondria;Modeling;Molecular;mouse model;Mus;Myocardial;Myocardial Infarction;Myocardial Ischemia;Neonatal;novel therapeutics;Nuclear;Oxidative Phosphorylation;Pathogenesis;Pathologic;Pathology;Pathway interactions;Patients;pediatric heart failure;Phase;Phosphorylation;Phosphotransferases;Physiological;Physiology;Post-Translational Protein Processing;Process;programs;Proliferating;Protein Acetylation;Proteins;Quality Control;Regulation;Research;Role;Sarcomeres;Serine;Signal Pathway;single nucleus RNA-sequencing;Stress;Structure;Testing;Therapeutic;transcription factor;transcriptomics;Treatment Failure;Work

PROJECT_TITLE: Cytoskeletal Control of Yap in Heart Regeneration

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-RCCS-Q(02)]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Chronic Pain;Drug Abuse (NIDA only);Neurosciences;Opioids;Pain Research;Substance Misuse

ORG_CITY: GAINESVILLE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Project Narrative: Our goal is to parse apart opioid-induced side effects from opioid-induced pain relief by developing new drugs that act differently at the opioid binding site on cells, the mu opioid receptor. The compounds that we have developed bind to the mu opioid receptor in a different way than morphine and fentanyl; moreover, they produce pain relief in rodents and primates at doses that do not produce respiratory suppression, the primary cause of opioid overdose. Herein we propose to understand how these new compounds interact with the receptor from a mechanistic perspective and how they will act in combination with known opioids such as fentanyl and morphine.

PI_NAMEs: BOHN, LAURA M. (contact)

PROGRAM_OFFICER_NAME: ANANTHAN, SUBRAMANIAM

PROJECT_TERMS: Absence of pain sensation;Acute;Adverse effects;Adverse event;Affinity;Agonist;allodynia;Analgesics;antinociception;Behavior;Binding;Binding Sites;Biochemical;Biological;Biological Assay;Cells;Cellular Membrane;Chemicals;Chronic;Detection;Development;Dose;drug action;drug structure;Fentanyl;Funding;G-Protein-Coupled Receptors;Goals;GTP-Binding Proteins;Hyperactivity;in vivo;Laboratories;Libraries;Ligands;Measurement;Measures;Molecular;Morphine;Motor Activity;mouse model;mu opioid receptors;Mus;Naloxone;Narcotics;novel strategies;novel therapeutics;Opioid;Opioid agonist;Opioid Analgesics;opioid overdose;Oxycodone;Paclitaxel;Pain;pain model;pain relief;painful neuropathy;Pharmaceutical Preparations;pharmacologic;Pharmacology;Physiological;Pre-Clinical Model;preference;prescription opioid;preservation;Primates;Property;radioligand;receptor;Receptor Signaling;recruit;Reporting;Resistance;respiratory;response;Rodent;scaffold;Scaffolding Protein;Series;side effect;Signal Pathway;Signal Transduction;Signaling Protein;Site;Site-Directed Mutagenesis;System;Testing;Therapeutic;therapeutic development;treatment response

PROJECT_TITLE: Biasing Mu Opioid Receptor Signaling in vivo

STUDY_SECTION: MCNP

STUDY_SECTION_NAME:
Molecular and Cellular Neuropharmacology Study Section
[MCNP]


NIH_SPENDING_CATS: Asthma;Lung;Natural Products;Neonatal Respiratory Distress;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: NARRATIVE  Babies born prematurely who are exposed to oxygen in the neonatal intensive care unit are at increased risk of airway diseases such as asthma, which makes it important to understand how oxygen detrimentally impacts the developing airways. The goal of this proposal is to use human cell and mouse models to investigate a novel, targetable mechanism (senescence) that we believe plays important roles in making developing airways more reactive and fibrotic (thus contributing to asthma). The importance of our work lies in the potential application of novel drugs that can target senescent cells (senolytics) for improving airway function in preterm infants and reduce the risk of developing asthma later in life.

PI_NAMEs: PRAKASH, Y. S.  (contact)

PROGRAM_OFFICER_NAME: LIN, SARA

PROJECT_TERMS: 3 year old;Adult;Adult asthma;Affect;Aging;Airway Disease;Airway Fibrosis;airway hyperresponsiveness;airway remodeling;Asthma;Bronchodilation;Cell Aging;Cell Count;Cell Cycle Arrest;Cell model;Cell secretion;cell type;Cells;Child;clinically relevant;clinically significant;Dasatinib;Data;Elements;endoplasmic reticulum stress;Exposure to;Extracellular Matrix;fetal;Fetal Lung;Fibrosis;fisetin;Flavonoids;Functional disorder;Future;Goals;Growth;Histology;Human;Hyperoxia;immune clearance;Impairment;improved;In Vitro;in vivo;Inflammation;Inflammatory;kinase inhibitor;Life;Lung;Mediating;Mesenchyme;Mitochondria;Modeling;mouse model;Mus;Neonatal;neonatal airway;Neonatal Hyperoxic Injury;Neonatal Intensive Care Units;neonatal mice;Newborn Infant;novel;novel therapeutics;Obstruction;Oxygen;paracrine;Pathway interactions;Perinatal;Pharmaceutical Preparations;Play;Pregnancy;premature;Premature Infant;Proliferating;Pulmonary Fibrosis;pup;Quercetin;repaired;respiratory smooth muscle;Risk;Risk Reduction;Role;senescence;senescence associated secretory phenotype;senescent cell;senolytics;Slice;Strawberries;Structure;Telomerase;Testing;Therapeutic;therapeutic target;Tissues;Vulnerable Populations;Work

PROJECT_TITLE: Cellular Senescence in Neonatal Airways

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


ADMINISTERING_IC: NS

ED_INST_TYPE: OVERALL MEDICAL

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Aging;Assistive Technology;Bioengineering;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Neurodegenerative;Neurosciences;Parkinson's Disease;Rehabilitation

ORG_CITY: CLEVELAND

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

ORG_STATE: OH

PHR: PROJECT NARRATIVE Parkinson’s disease (PD) is a progressive neurological disorder that alters the brain circuitry involved in movement control and affects more than ten million people worldwide. This project will help to establish a new closed-loop deep brain stimulation (DBS) tool that we can use in humans to characterize the role of frequency- specific neural activity in PD as well as other brain conditions, and to determine if controlled suppression or amplification of synchronized oscillations in the subthalamic nucleus of PD patients influences the severity of bradykinesia and rigidity. If the studied influence is causal, our DBS approach could become an alternative treatment of PD that can be programmed based on patient-specific neurophysiological data, relevant to reducing health care costs associated with tuning traditional (open-loop) DBS therapies using a trial-and-error process.

PI_NAMEs: ESCOBAR SANABRIA, DAVID  (contact)

PROGRAM_OFFICER_NAME: SIEBER, BETH-ANNE

PROJECT_TERMS: Address;Affect;Algorithms;alternative treatment;Animal Model;Basal Ganglia;Bradykinesia;Brain;brain circuitry;Clinical;clinical translation;Clinical Trials;clinically relevant;Computer Models;Data;Dedications;Deep Brain Stimulation;Development;Devices;electric field;Electric Stimulation;Electroencephalography;Electrophysiology (science);Elements;Engineering;Etiology;Feedback;Frequencies;Functional disorder;Future;Generations;Health Care Costs;Human;Image;Implant;Incidence;Infrastructure;insight;Knowledge;Lead;Levodopa;Link;Magnetic Resonance Imaging;Measures;Mediating;Modeling;Motor;Motor Cortex;motor disorder;Motor Manifestations;Movement;National Institute of Neurological Disorders and Stroke;Nervous System Disorder;neural;neural circuit;Neurons;neurophysiology;neuroregulation;novel therapeutics;Parkinson Disease;Parkinsonian Disorders;Pathway interactions;Patients;Persons;Pharmaceutical Preparations;Physiology;Population;Predisposition;Process;programmed cell death protein 1;Recommendation;Research;Resolution;response;Role;sensor;sensor technology;Severities;Shapes;STN stimulation;Structure of subthalamic nucleus;System;Techniques;Technology;theories;Time;tool;treatment optimization;Variant

PROJECT_TITLE: Identifying Circuit Dynamics Underlying Motor Dysfunction in Parkinsons Disease Using Real-Time Neural Control

STUDY_SECTION: BNVT

STUDY_SECTION_NAME: Bioengineering of Neuroscience, Vision and Low Vision Technologies Study Section[BNVT]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: Project Narrative    Chromatin  is  a  dynamic  structure  that  requires  constant  assembly  and  disassembly.  Histone  proteins  are  the  subunits of chromatin and require dedicated chaperone to orchestrate their function. This application will define  a  novel  histone  chaperone  pathway  for  new  and  evicted  histone  ad  define  a  new  mode  of  crosstalk  between  chromatin assembly and nucleotide synthesis.

PI_NAMEs: FOLTZ, DANIEL RICHARD (contact)

PROGRAM_OFFICER_NAME: CHOW, CHI-WING

PROJECT_TERMS: Acetylation;Binding;Biology;Cells;Chromatin;Chromatin Modeling;Coupled;Coupling;Data;Dedications;Deposition;Disease;DNA;DNA Adducts;DNA biosynthesis;DNA replication fork;Drops;Elements;Enzymes;Gene Expression;Genetic Transcription;Genome;Histone Acetylation;histone acetyltransferase;Histone H3;Histone H4;histone methylation;histone modification;Histones;Knowledge;Mentored Clinical Scientist Development Program;Metabolic Control;Metabolic Pathway;Metabolism;Methylation;Modification;Molecular;Molecular Chaperones;novel;Nuclear;Nucleosomes;Nucleotide Biosynthesis;nucleotide metabolism;Nucleotides;Outcome;Pathway interactions;Population;Post-Translational Protein Processing;prevent;Process;Proliferating;Protein Isoforms;Protein Subunits;Proteins;Regulation;replication stress;Role;Slide;Somatic Cell;Source;Specificity;Structure;Time;Transferase;Variant;Work

PROJECT_TITLE: Histone chaperone networks for new and evicted histones

STUDY_SECTION: MGB

STUDY_SECTION_NAME: Molecular Genetics B Study Section[MGB]


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: CHAPEL HILL

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: NARRATIVE Large genetic studies are important for understanding disease risk, including for obesity, but further work is needed to understand the processes affected by genetic factors. This study will combine multiple types of biological measures to identify genetic variations contributing to obesity, evaluate their medical utility, and confirm their functional role through experimentation. In the end, this project will lead to a more complete knowledge of obesity.

PI_NAMEs: JUSTICE, ANNE ;LIU, CHING-TI ;NORTH, KARI E. (contact)

PROGRAM_OFFICER_NAME: PAWLIKOWSKA, LUDMILA SYLWIA

PROJECT_TERMS: Adipose tissue;Affect;Aging;American;biobank;Biological;Biological Markers;Blood;Body mass index;Brain;Candidate Disease Gene;Cardiometabolic Disease;causal variant;Cells;Clinical;clinically relevant;clinically significant;cohort;Collaborations;Collection;Community Health;cost;CRISPR/Cas technology;Critical Pathways;Data;Databases;Disease;disorder risk;DNA Sequence Alteration;efficacy evaluation;Electronic Health Record;epigenomics;Etiology;exome sequencing;follow-up;Foundations;Frequencies;Gene Expression;Genes;Genetic;genetic architecture;Genetic Predisposition to Disease;Genetic study;Genetic Variation;genome editing;genome sequencing;genome wide association study;genome-wide;genomic epidemiology;Genomics;Health;Health Care Costs;Heart;improved;In Vitro;Individual;individualized prevention;innovation;insight;Investigation;Knowledge;Link;Liver;Maps;Measures;Medical;Meta-Analysis;metabolomics;Methods;methylomics;Molecular;Morbidity - disease rate;mortality;multiple omics;novel;Obesity;Obesity associated disease;obesity risk;Outcome;Participant;Pathogenesis;Pathway interactions;Penetrance;phenome;Phenotype;Physiological;polygenic risk score;precision medicine;Precision therapeutics;Prevention;Procedures;Process;programs;Public Health Applications Research;rare variant;Regulation;Regulatory Element;Reporting;Research;risk variant;Role;Scanning;Signal Transduction;Susceptibility Gene;Tissues;trait;Transcript;transcriptomics;Translating;Translations;Untranslated RNA;Variant;waist circumference;Waist-Hip Ratio;whole genome;Work

PROJECT_TITLE: Integrative Approaches to Identifying Function and Clinical Significance of Adiposity Susceptibility Genes

STUDY_SECTION: KNOD

STUDY_SECTION_NAME: Kidney, Nutrition, Obesity and Diabetes Study Section[KNOD]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Neurosciences;Pediatric;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: Aurora

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative The olfactory epithelium is one of only three prominent regions within the mammalian nervous systems where new neurons are incorporated throughout life, but a major challenge remains to understand how olfactory sensory neuro- genesis is regulated and maintained. In humans, the failure of persistent olfactory sensory neurogenesis is strongly linked to olfactory dysfunction, which can adversely affect health and quality of life, and for which treatment options are currently limited and often ineffective. The proposed studies are expected to provide insights into fundamental aspects of persistent olfactory sensory neurogenesis, including how it is regulated, how it functions, and how it may be manipulated to enhance human health.

PI_NAMEs: SANTORO, STEPHEN  (contact)

PROGRAM_OFFICER_NAME: SULLIVAN, SUSAN L

PROJECT_TERMS: Acceleration;Adult;Affect;Age;Bar Codes;Birth;Birth Rate;Cell division;Cell Proliferation;Daughter;Development;developmental neurobiology;experience;experimental study;Exposure to;Failure;Female;Gene Expression;Genes;Genetic;Genome;Goals;Health;Hippocampus;Human;in situ sequencing;Individual;insight;Knockout Mice;Knowledge;Laboratories;Learning;Life;life span;Link;male;Mammals;Maps;Memory;Mitotic;Modeling;Nature;nerve stem cell;Nervous System;Nervous System Disorder;neurogenesis;Neuronal Differentiation;Neurons;Odorant Receptors;Odors;olfactory bulb;Olfactory dysfunction;Olfactory Epithelium;olfactory sensory neurons;olfactory stimulus;Play;Population;postmitotic;postnatal;Probability;Process;progenitor;Proliferating;Quality of life;receptor expression;Receptor Gene;Regulation;Role;selective expression;Sensory;sex;Signal Transduction;single cell sequencing;single-cell RNA sequencing;stem cell fate;stem cell proliferation;Stimulus;Testing;Work

PROJECT_TITLE: The olfactory stimulation-dependent birth of neurons that express specific odorant receptors

STUDY_SECTION: NIC

STUDY_SECTION_NAME: Neuroscience of Interoception and Chemosensation Study Section[NIC]


ADMINISTERING_IC: TW

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Clinical Research;Health Effects of Indoor Air Pollution;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Social Determinants of Health

ORG_CITY: CHENNAI

ORG_COUNTRY: INDIA

ORG_FIPS: IN

ORG_NAME: SRI RAMACHANDRA INSTITUTE OF HIGHER EDUCATION AND RESEARCH TRUST

PHR: PROJECT NARRATIVE Impacts from air pollution exposures on adverse pregnancy outcomes can have serious consequences for populations in low and middle income countries (LMICs) struggling to improve maternal and child health in the face of multiple risk factors. The proposed research will use novel exposure assessment tools to generate extensive (environmental and biomarker based) pregnancy period exposure information for PM2.5 and PAHs in relation birth outcomes in India. Evidence from the study will inform monitoring and evaluation efforts directed at maternal and child health in India and other LMICs.

PI_NAMEs: PUTTASWAMY, NAVEEN  (contact)

PROGRAM_OFFICER_NAME: JESSUP, CHRISTINE

PROJECT_TERMS: Acute;Address;Adult;Adverse effects;adverse pregnancy outcome;Air;air contaminant;Air Pollution;ambient air pollution;Ambulatory Care Facilities;Annual Reports;Anthropometry;Aromatic Polycyclic Hydrocarbons;Assessment tool;attributable mortality;Automobile Driving;Binding;Biological Assay;Biological Markers;Birth;Birth Rate;Birth Weight;burden of illness;Capital;career development;Cessation of life;Chemicals;Child;Cities;cohort;Deoxyguanosine;Devices;Enrollment;Environmental Exposure;Evaluation;experience;Exposure to;Fetal Development;fine particles;Gases;Grant;Guidelines;Health;High Prevalence;Hospitals;Hour;improved;India;Individual;Institution;Length;Leukocytes;Link;Live Birth;low and middle-income countries;Low Birth Weight Infant;Low Prevalence;Lower Respiratory Tract Infection;Manuscripts;Mass Spectrum Analysis;Maternal and Child Health;Measurement;Measures;Methods;Modeling;Monitor;Naphthols;Neonatal;Neonatal Mortality;novel;Outcome;oxidative damage;Participant;particle;Persons;pollutant;Population;Predisposition;Pregnancy;pregnant;Pregnant Women;Premature Birth;prenatal;Public Health;recruit;Regression Analysis;Reporting;Research;Research Personnel;response;Risk Factors;Role;Rural;Sampling;secondary analysis;skills;Source;Study models;Techniques;telomere;Third Pregnancy Trimester;Training;Umbilical Cord Blood;United States National Institutes of Health;urban setting;urinary;Variant;wearable device;Work;World Health Organization;wristband;Writing

PROJECT_TITLE: PRENATAL FINE PARTICULATE MATTER (PM2.5) AND POLYCYCLIC AROMATIC HYDROCARBON (PAH) EXPOSURES AND THEIR ASSOCIATION WITH BIRTHWEIGHT IN SOUTHERN INDIA

STUDY_SECTION_NAME: International and Cooperative Projects - 1 Study Section[ICP1]


ADMINISTERING_IC: LM

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: PROJECT NARRATIVE There is an urgent need to train obstetrics and gynecology (Ob/Gyn) health professionals on structural and social determinants of health, and the role of health care bias in perpetuating and exacerbating sexual, reproductive, and maternal health disparities. We will design, implement, and evaluate a curriculum for medical student learners about the intersection of race, ethnicity, sex, and gender in Ob/Gyn health care equity, including didactic modules and a reflective learning community app to provide space for active learning and peer exchange. We will implement the course with 140 medical school learners completing mandatory Ob/Gyn clerkship and elective didactics and conduct longitudinal surveys following the Kirkpatrick model to evaluate learner experience, understanding, ability, and growth.

PI_NAMEs: JANEVIC, TERESA ;STERN, TONI  (contact)

PROGRAM_OFFICER_NAME: BARR, ELIZABETH ANNE

PROJECT_TERMS: Active Learning;Advocate;anti-racism;Area;Awareness;Behavior;Biological;care outcomes;career;Caring;Categories;Clinical;clinical care;Clinical Clerkship;clinical training;Collaborations;Communities;community advisory board;community engagement;Competence;Creativeness;curriculum development;Data;design;Dimensions;Discipline of obstetrics;Discrimination;diversity and inclusion;Education;Educational Activities;Educational Curriculum;Equitable healthcare;Equity;Ethnic Origin;Evidence based practice;experience;Faculty;Family;Focus Groups;Foundations;Gender;gender diverse;Goals;Growth;Gynecologic;Gynecology;Health;health care delivery;health care quality;health communication;health disparity;health equity;health inequalities;Health Professional;Health Services Research;Health system;health training;Healthcare;Immigration;improved;Individual;Instruction;intersectionality;Intervention;Justice;Knowledge;Learning;learning community;lectures;Left;Life Cycle Stages;Longitudinal Surveys;Maternal Health;Medical;medical schools;Medical Students;Medicine;Mission;Modeling;next generation;novel;Obesity;Outcome;outcome disparities;Patient-Centered Care;Patient-Focused Outcomes;Patients;peer;Physicians;portability;programs;Quality of Care;Race;racism;Reaction;reproductive;Reproductive Health;Reproductive Sciences;Research;research in practice;Research Institute;Role;sex;Sex Orientation;sexual and reproductive health;Sexual Health;skills;social determinants;social health determinants;structural determinants;structural health determinants;Structural Racism;Students;Surveys;systems research;Testing;tool;Training;Training Programs;woman health professional;women faculty;Women's Health;women's outcomes;Work

PROJECT_TITLE: Developing a curriculum in obstetric, gynecologic, and reproductive health care equity to bridge research and practice

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-EMS-K(50)R]


NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Gene Therapy;Genetics;Heart Disease;Orphan Drug;Rare Diseases

ORG_CITY: NEW ORLEANS

ORG_NAME: LSU HEALTH SCIENCES CENTER

ORG_STATE: LA

PHR: Nerrative The successful implementation of this proposed study will fill knowledge gaps and provide new insights into the regulatory mechanisms of myocardial energetics and metabolism, providing novel therapeutic targets for effective treatment of heart failure.

PI_NAMEs: YANG, QINGLIN  (contact)

PROGRAM_OFFICER_NAME: DESVIGNE-NICKENS, PATRICE

PROJECT_TERMS: Acute;adeno-associated virus 9 delivery;Adult;advanced disease;Aerobic;Animals;Aortic Valve Stenosis;ascending aorta;Biogenesis;Cardiac;Cardiac Myocytes;Cardiomyopathies;Cause of Death;Congestive Heart Failure;Cytosol;Death Rate;Defect;Development;Diabetes Mellitus;Dilated Cardiomyopathy;Disease;effective intervention;effective therapy;efficacy testing;embryo culture;Energy consumption;Etiology;experimental study;Fatty Acids;Fibroblasts;Foundations;Functional disorder;gene therapy;gene-targeted therapy;Glucose;Heart;Heart failure;heart function;Heart Hypertrophy;Homeostasis;Hypertension;Hypertrophy;Impairment;improved;Inherited;innovation;insight;Ketone Bodies;Knowledge;Lead;Left;Left ventricular structure;Mediating;Metabolic;Metabolism;Mitochondria;Mitochondrial Diseases;Modeling;Molecular Machines;Morphology;Multienzyme Complexes;Mus;Mutation;Myocardial;Myocardial dysfunction;Neuromuscular Diseases;new therapeutic target;novel;oligomycin sensitivity-conferring protein;oxidation;Oxidative Phosphorylation;Pathologic;Patient Care;Patients;Performance;Physiologic intraventricular pressure;Play;pre-clinical;preference;pressure;Production;protective effect;Pump;Rattus;Respiration;Risk Factors;Role;Side;Stress;Structure;System;Testing;Therapeutic;therapeutic development;Virulence Factors

PROJECT_TITLE: Energetic State and Metabolic Remodeling in Cardiac Hypertrophy and Failure

STUDY_SECTION: MPPA

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology A Study Section [MPPA]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;HIV/AIDS;Health Services;Pediatric;Pediatric - AIDS;Prevention;Social Determinants of Health

ORG_CITY: BOSTON

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

ORG_STATE: MA

PHR: PROJECT NARRATIVE A culturally-relevant, theoretically and empirically sound, patient-centered, standardized disclosure intervention that can be integrated into routine clinical pediatric HIV care that has the potential to prevent transmission and improve the welfare of children and their caregivers in low- and middle-income countries. We aim to build upon the successful Sankofa study by conducting a pragmatic, stepped wedge cluster randomized trial in high prevalence regions in Ghana to inform the benefits of pediatric HIV disclosure.

PI_NAMEs: PAINTSIL, ELIJAH  (contact);REYNOLDS, NANCY R

PROGRAM_OFFICER_NAME: ESBER, ALLAHNA LAUREN

PROJECT_TERMS: 18 year old;Academy;Adherence;Adolescent;Africa South of the Sahara;Age;American;Anti-Retroviral Agents;Appointment;Area;Behavioral;Caregivers;Caring;Child;Child Welfare;Childhood;Clinic;Clinical;Cluster randomized trial;community advisory board;Control Groups;coping;cost;cost effectiveness;cost outcomes;Counseling;Data;Development;Diagnosis;Disclosure;effective intervention;effectiveness evaluation;Elements;Ethics;Family;Family Relationship;Fright;Future;Ghana;Health;health assessment;Health behavior change;Health Benefit;Health Care Costs;Health Personnel;Health Services;High Prevalence;HIV;HIV diagnosis;HIV Seropositivity;Home;Immunologics;improved;Individual;Intervention;intervention delivery;Investigation;Knowledge;low and middle-income countries;Maintenance;medication compliance;member;Modeling;Motivation;novel;Outcome;Parents;patient oriented;pediatric human immunodeficiency virus;Pediatrics;post intervention;Predictive Factor;prevent;primary endpoint;primary outcome;Probability;Process;Psychological adjustment;psychosocial;randomized trial;Recommendation;recruit;Research;Research Personnel;Risk;routine care;scale up;School-Age Population;secondary outcome;sexually active;Site;skills;social;social culture;social stigma;sound;Standardization;Structure;Systems Theory;Testing;Time;Training;transmission process;treatment group;Uncertainty;Universities;World Health Organization

PROJECT_TITLE: Pediatric HIV Disclosure Intervention and Benefits Study-(PH-DIBS)

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Digestive Diseases;Inflammatory Bowel Disease;Microbiome;Prevention

ORG_CITY: BIRMINGHAM

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE: The immune system deploys a coordinated set of mechanisms that collectively enable peaceful co-existence with the bacteria that occupy various niches of the gastrointestinal tract. The absence of several of these pathways is associated with an increased risk of intestinal inflammation. This project will explore potential mechanisms whereby spontaneous inflammatory responses to bacteria that inhabit the mucus lining of the large intestine may be averted.

PI_NAMEs: MAYNARD, CRAIG L (contact)

PROGRAM_OFFICER_NAME: HUDSPETH, KELLY

PROJECT_TERMS: Adult;Affinity;Antibodies;Antibody Response;Antigens;antimicrobial;Ascending colon;Bacteria;bacterial community;Benign;CD4 Positive T Lymphocytes;Cells;cohort;Colitis;Colon;Colonic inflammation;commensal microbes;Communities;Complex;cytokine;Dendritic Cells;Disease;draining lymph node;Epithelial Cells;Epithelium;Etiology;Family member;Flagellin;gastrointestinal epithelium;Gastrointestinal tract structure;Gnotobiotic;gut inflammation;Homeostasis;host microbiota;IgG1;Immune;Immune response;Immune system;Immunity;immunogenicity;Immunoglobulin A;Immunoglobulin G;immunoregulation;Impairment;Inflammation;Inflammatory Bowel Diseases;Inflammatory Response;Interleukin-10;intestinal epithelium;Intestines;Invaded;Knowledge;Large Intestine;Life;Maintenance;Mastigophora;Mediating;Microbe;microbial;microbiota;microbiota composition;Modeling;Mucous body substance;Mucous Membrane;Mus;mutualism;Normalcy;novel;Organism;pathogen;Pathogenicity;Pathway interactions;Penetration;Phylogenetic Analysis;prevent;Prevention;Production;Regulation;resident commensals;response;Risk;risk mitigation;Role;synergism;Testing;Thymus Gland

PROJECT_TITLE: Immune Interactions with the Mucus-Associated Microbiota

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIB-E(91)]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Dental, Oral, and Craniofacial Disease;Infectious Diseases;Nanotechnology;Regenerative Medicine;Transplantation

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: PROJECT NARRATIVE Alveolar bone is essential for supporting teeth and dental implants, but its loss commonly occurs in chronic inflammatory oral diseases, causing severe reductions in quality of life due to the impairment of many basic daily functions such as eating and speaking. Despite its high prevalence, there is no effective treatment in the clinic to reverse alveolar bone loss associated with excessive inflammation. To address this significant unmet public health need, we aim to bioengineer an innovative 3D printed biomimetic and immunomodulatory alveolar bone implant that can effectively resolve periodontal inflammation and promote alveolar bone tissue regeneration.

PI_NAMEs: JANG, HAE LIN  (contact)

PROGRAM_OFFICER_NAME: VERBRIDGE, SCOTT SPENCER

PROJECT_TERMS: 3-Dimensional;3D Print;Acute;Address;Affinity;Age;aging population;Allografting;alveolar bone;Alveolar Bone Loss;American;Architecture;Area;Autologous Transplantation;Binding;Biological Factors;Biomedical Engineering;Biomimetics;bone;Bone Cements;Bone Formation Stimulation;bone loss;Bone Regeneration;Bone Transplantation;Cementation;Childhood;Chronic;chronic inflammatory disease;Clinic;Clinical;Clinical Research;Complex;Cytoplasmic Granules;daily functioning;Data;Defect;Dental Implants;Development;Disease;disease transmission;dysbiosis;early childhood;Eating;effective therapy;Effectiveness;Exhibits;experience;Failure;Feedback;fetal;Growth;Harvest;High Prevalence;Homeostasis;Human;Human body;Hydroxyapatites;Immune;Immunologics;immunoregulation;Impairment;Implant;implantation;improved;in utero;In Vitro;Infection;infection risk;Inflammation;Inflammatory;inflammatory bone loss;Inflammatory Response;Injectable;Ink;innovation;lipid mediator;Mandible;Mediating;Mediator;Medical;Methods;microbiome;mimetics;Minerals;Modeling;Morbidity - disease rate;Mouth Diseases;nanoparticle;Natural regeneration;neutrophil;next generation;novel;novel strategies;Operative Surgical Procedures;Organ;Osteitis;Osteogenesis;osteogenic;Pain;particle;pathogen;Pathway interactions;Patients;peri-implantitis;Periodontitis;Persons;Pharmaceutical Preparations;preclinical study;prevent;Procedures;Process;Production;Prognosis;Property;Public Health;Quality of life;Rattus;Regenerative capacity;Research;Research Project Grants;Resolution;Safety;Shapes;Site;skeletal;Structure;Surface;therapeutic effectiveness;tissue regeneration;Tissues;Tooth Loss;Tooth structure;Translating;tricalcium phosphate;Viscosity;Xenograft procedure

PROJECT_TITLE: A novel bioengineering approach to restoring permanent periodontal inflammatory bone loss

STUDY_SECTION: MTE

STUDY_SECTION_NAME: Musculoskeletal Tissue Engineering Study Section[MTE]


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Endocrine Disruptors;Genetics

ORG_CITY: ALBANY

ORG_DEPT: BIOLOGY

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT ALBANY

PHR: NARRATIVE  Our research program in Environmental Epitranscriptomics has demonstrated that the levels of over 23 RNA modifications are altered in response to toxicants to regulate the translation of stress response transcripts. Here we will define mechanistic details of codon-biased translation in response to different xenobiotics, and identify toxicant-, cell- and organ-specific epitranscriptomic response programs in rat tissue and human cell models. Our studies will define the biomarker potential for RNA modifications to asses exposures to arsenite and other toxicants, and then test the idea that whole blood and white blood cells (WBCs) serve as an accessible sampling compartment for human epitranscriptome biomarker studies.

PI_NAMEs: BEGLEY, THOMAS J (contact);DEDON, PETER C

PROGRAM_OFFICER_NAME: TYSON, FREDERICK L

PROJECT_TERMS: Acids;Amino Acids;Arsenates;Arsenic;Arsenic Trioxide;Arsenites;base;Behavior;biological adaptation to stress;Biological Markers;Biology;biomarker signature;Blood;Cacodylic Acid;Cell Line;Cell model;Cell Survival;Cells;Codon Nucleotides;Data;Databases;Defect;Detection;Diethylnitrosamine;Dose;Drug Metabolic Detoxication;Environmental Exposure;epitranscriptome;epitranscriptomics;Exposure to;Foundations;Gene Expression;Genes;glutathione peroxidase;Heart;Hepatocyte;HepG2;Human;human model;In Vitro;in vivo;Kidney;knock-down;Leukocytes;Lipopolysaccharides;Liver;Lymphocyte;Mitochondria;Modeling;Modification;Mus;Nucleoside Q;Organ;Pharmaceutical Preparations;Population;programs;Proteins;Proteome;Proteomics;Rattus;Reactive Oxygen Species;Research;response;RNA;Role;Sampling;Selenocysteine;Sodium;sodium arsenite;Technology;Testing;Therapeutic;Time;Tissues;toxicant;Toxicant exposure;Transcript;Transfer RNA;Translating;translational model;Translational Regulation;Translations;usability;Whole Blood;Xenobiotics;Yeasts

PROJECT_TITLE: Translational regulation in exposure biology - Xenobiotic-induced reprograming of tRNA modifications and selective translation of codon-biased response genes in rat and human models

STUDY_SECTION: SIEE

STUDY_SECTION_NAME: Systemic Injury by Environmental Exposure[SIEE]


NIH_SPENDING_CATS: Nutrition;Obesity

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

ORG_STATE: CA

PHR: PROJECT NARRATIVE Obesity is an important health problem in the U.S. This project will study proteins that control energy balance in the body, which can lead to new approaches for obesity therapy.

PI_NAMEs: YOON, JOHN C (contact)

PROGRAM_OFFICER_NAME: LYNCH, CHRISTOPHER

PROJECT_TERMS: Adipocytes;Adipose tissue;Adrenergic Agents;Adrenergic Receptor;Affect;Alanine;Anti-Obesity Agents;Area;ATP Hydrolysis;Back;Binding;Biological Assay;blood glucose regulation;Body Composition;Body Weight;Brown Fat;Ca(2+)-Transporting ATPase;Chemicals;Child;combat;Creatine;Data;Desire for food;Ectopic Expression;Endoplasmic Reticulum;endoplasmic reticulum stress;energy balance;Energy consumption;Energy Metabolism;Exhibits;Extravasation;Fatty acid glycerol esters;Fluorescence Resonance Energy Transfer;fluorodeoxyglucose positron emission tomography;Future;gain of function;Genes;Genetic Polymorphism;Health;Health Care Costs;High Fat Diet;Human;improved;in vivo;Indirect Calorimetry;inhibitor;insight;Knock-out;Knockout Mice;Link;Lipids;Lipolysis;Marketing;Measures;Mediating;medical complication;Membrane Proteins;Metabolic;Modeling;Monitor;mouse model;Mus;Mutagenesis;novel;novel strategies;novel therapeutic intervention;Obesity;obesity treatment;overexpression;Parents;pharmacologic;phospholamban;Physiological;Play;Positron-Emission Tomography;Process;Proteins;Pump;Reagent;Regulation;Reporting;Resistance;Respiration;response;Role;sarcolipin;Signal Transduction;Site;small molecule;Stimulus;Temperature;Testing;Therapeutic;Thermogenesis;Tissues;trafficking;uncoupling protein 1;United States;uptake;warm temperature;wasting;Work

PROJECT_TITLE: NNAT in metabolic regulation

STUDY_SECTION: POMD

STUDY_SECTION_NAME: Pathophysiology of Obesity and Metabolic Disease Study Section[POMD]


ADMINISTERING_IC: EY

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL EYE INSTITUTE

ORG_CITY: SALT LAKE CITY

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Project Narrative Vision research spans a vast range of basic science areas (cell biology, molecular biology, neurobiology, chemistry, biochemistry, computer science, human and mouse genetics, optics, physiology) with strong traditional links to neuroscience and newly evolving dimensions in translational research on ocular diseases. The principle underlying the Vision Research Core (VRC) at the University of Utah is that research excellence is best served by ready access to resources outside the scope of individual R01 awards, ready access to technical expertise outside the scope a single laboratory, and staff training to remove barriers to efficient translational research and collaboration.

PI_NAMEs: BERNSTEIN, PAUL STEVEN (contact)

PROGRAM_OFFICER_NAME: GOVER, TONY DOUGLAS

PROJECT_TERMS: Animal Model;Anterior;Area;Award;Basic Science;behavior test;Biochemistry;Cellular biology;Chemistry;Collaborations;computer science;confocal imaging;Cryoultramicrotomy;Databases;design;developmental disease;Dimensions;Disease;Electrophysiology (science);Evolution;Eye;eye center;Eye diseases;Faculty;Gel;Genes;Genotype;Glaucoma;Grant;High Pressure Liquid Chromatography;Human Genetics;Image;Imaging Device;immunocytochemistry;In Situ Hybridization;In Vitro;in vivo;Individual;Knowledge;Laboratories;Ligands;Link;Mass Fragmentography;Mathematics;metabolomics resource;Molecular;Molecular Biology;mouse genetics;Mus;Neurobiology;Neurosciences;ocular imaging;Optics;Physiology;Preparative Centrifugation;Proteins;Proteomics;Research;Research Personnel;Research Project Grants;Resources;Retina;Retinal Degeneration;Scanning;Schools;Science of genetics;Services;Silicon;Software Tools;Surface Plasmon Resonance;System;Technical Expertise;Technology;Tissues;tool;Training;Translational Research;two-photon;Ultracentrifugation;Universities;Utah;Validation;Vision research;Western Blotting;working group

PROJECT_TITLE: University of Utah Core Vision Research Grant


NIH_SPENDING_CATS: Bioengineering;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences

PI_NAMEs: JONES, BRYAN WILLIAM (contact)

PROJECT_TERMS: Anatomy;Architecture;Area;Award;Basic Science;Biology;Collaborations;Computer software;confocal imaging;Data Storage and Retrieval;Databases;developmental disease;Disease;Evolution;experience;Glaucoma;Image;Imagery;Individual;Laboratories;large scale data;Maps;Mathematics;Metabolic;metabolomics;Microscopy;Molecular;Molecular Computations;molecular phenotype;Normal tissue morphology;novel;operation;optical imaging;Optics;petabyte;Research;Research Personnel;Research Project Grants;Resources;Retinal Degeneration;Scanning;Schools;Services;Silicon;software repository;Software Tools;Speed;statistics;System;Technical Expertise;Tissues;Training;Translational Research;Universities;Utah;Vision research;Visual System;web app;working group

PROJECT_TITLE: Imaging


NIH_SPENDING_CATS: Biotechnology;Eye Disease and Disorders of Vision;Genetics;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human;Stem Cell Research - Nonembryonic - Non-Human

PI_NAMEs: YANG, JUN  (contact)

PROJECT_TERMS: Area;Award;Basic Science;Cell Culture Techniques;Cells;Cellular biology;Collaborations;Consultations;Cryopreservation;Cryoultramicrotomy;developmental disease;Disease;Evolution;eye center;Faculty;Future;Generations;Genotype;Glaucoma;immunocytochemistry;Individual;induced pluripotent stem cell;Laboratories;mouse genetics;Mus;Organoids;Paraffin Embedding;preservation;Research;Research Personnel;Research Project Grants;Resources;Retina;Retinal Degeneration;Services;System;Technical Expertise;tissue culture;Training;Translational Research;Universities;Utah;Vision research;working group

PROJECT_TITLE: Cell Biology


NIH_SPENDING_CATS: Biomedical Imaging;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences

PI_NAMEs: KRIZAJ, DAVID  (contact)

PROJECT_TERMS: Administrative Supplement;Animal Model;Area;Award;Basic Science;Behavior;Behavior assessment;behavior test;Collaborations;developmental disease;Diabetic Retinopathy;Diagnostic;Disease;Electroretinography;Evolution;Faculty;Floor;Funding;Glaucoma;Human;Image;image guided;Imaging Device;imaging system;In Vitro;in vivo;in vivo imaging;Individual;Ischemia;Laboratories;Laser injury;Microscope;Microscopy;Mus;ocular imaging;Ophthalmology;Phenotype;Physiology;Research;Research Personnel;Research Project Grants;Resolution;Resources;Retina;Retinal Degeneration;Retinal Diseases;Structure;System;Systems Biology;Technical Expertise;Therapeutic Intervention;tool;Training;Translational Research;two-photon;Universities;Utah;Validation;vestibular system;Vision research;Visual;Visual System;working group

PROJECT_TITLE: Physiology


NIH_SPENDING_CATS: Biotechnology;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences

PROJECT_TERMS: Antibodies;archive data;Area;Award;Basic Science;Biochemical;Biochemistry;Biosensor;Carotenoids;Cells;Cholesterol;Collaborations;data archive;Detection;developmental disease;Disease;DNA;Electroporation;Evolution;Faculty;Fatty Acids;Flavonoids;Gel;Genes;Glaucoma;High Pressure Liquid Chromatography;Image;in vivo;Individual;instrumentation;interest;intermolecular interaction;Laboratories;Ligands;Lipids;Lipofuscin;Mass Fragmentography;metabolomics resource;Molecular Biology;Neonatal;Nucleic Acids;Oligonucleotides;Organelles;Photoreceptors;plasmid DNA;Plasmids;Protein Analysis;protein expression;Proteins;Proteomics;Radioactivity;Research;Research Personnel;Research Project Grants;Resources;Retinal Degeneration;Retinoids;Services;Shuttle Vectors;small molecule;Sucrose;Surface Plasmon Resonance;Technical Expertise;Technology;Training;Transfection;Translational Research;Ultracentrifugation;Universities;Utah;Vision research;Western Blotting;working group;X-Ray Film

PROJECT_TITLE: Biochemistry


NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Neurosciences;Physical Injury - Accidents and Adverse Effects;Rehabilitation;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_DEPT: OTHER BASIC SCIENCES

PHR: Project Narrative Spinal cord injury resulting in paralysis affects more than 250,000 people nationwide. Implant technology is now available to infer one's desired movement from signals recorded from microelectrode arrays implanted in the brain areas that control movement. Implanted stimulation technology can now reanimate paralyzed muscles, and combining these technologies has the potential to restore reaching movements by thought after paralysis. The goal of this study is to improve stimulation control algorithms to optimize limb motion and stability while also minimizing fatigue and conserving battery power.

PI_NAMEs: AJIBOYE, ABIDEMI BOLU;TAYLOR, DAWN MARIE (contact)

PROGRAM_OFFICER_NAME: DOPERALSKI, ADELE ELIZABETH

PROJECT_TERMS: Acceleration;Activities of Daily Living;Affect;algorithm development;Algorithms;Animal Model;Animals;antagonist;Area;arm;arm function;arm movement;Brain;brain computer interface;Caregivers;Cervical;Cervical spinal cord injury;Charge;Chronic;Clinical Trials;Computer Models;Deceleration;Department of Defense;Development;Devices;Emotional;Enrollment;Ensure;Environment;family burden;Fatigue;Feedback;Financial Hardship;Freedom;functional electrical stimulation;Funding;Goals;Hand;Human;human model;human study;Impairment;Implant;Implanted Electrodes;improved;Individual;Industry;infancy;Injury;kinematics;Lead;Learning;Limb structure;Maps;Methods;Microelectrodes;Modeling;Motion;Motor;motor learning;Movement;Muscle;Muscle Fatigue;Neck;neural;Neurons;nonhuman primate;Paralysed;Participant;Pattern;Performance;Peripheral Nerves;Persons;Population;Positioning Attribute;Predisposition;Recovery;Resistance;restoration;Signal Transduction;skills;Speed;Spinal cord injury;System;Technology;Testing;Thinking;Time;Translating;Upper Extremity;wasting;Work

PROJECT_TITLE: Improving intracortical control of reaching after paralysis

STUDY_SECTION: SMI

STUDY_SECTION_NAME: Sensorimotor Integration Study Section[SMI]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

ORG_CITY: UNIVERSITY

ORG_NAME: UNIVERSITY OF MISSISSIPPI

ORG_STATE: MS

PHR: Project Narrative: Coordination of the actin and microtubule cytoskeleton through molecular motors and associated proteins is essential for performing vital large-scale cellular tasks such as cell division and motility, and, as such, deficits in these proteins lead to devastating diseases and cancer. This project aims to provide fundamental molecular- level understanding of this critical cytoskeletal crosstalk using an interdisciplinary approach -- engineering novel, physiologically relevant assays to study the cytoskeleton’s mechanistic underpinnings using powerful biophysical tools. These findings will not only facilitate deeper understanding of the molecular mechanisms that sustain life, but also be the foundation for developing screening and diagnostic tools to better predict and treat cytoskeletal- based diseases.

PI_NAMEs: REINEMANN, DANA NICOLE (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TERMS: Actins;Affect;Architecture;Binding Proteins;Biological Assay;Biophysical Process;biophysical tools;Cell division;Cell model;cell motility;Cell Physiology;Cells;Communication;Complex;crosslink;Crosslinker;Cytoskeleton;diagnostic strategy;diagnostic tool;Disease;Disparate;Elements;Engineering;Environment;Equilibrium;experimental study;Family;Filament;Foundations;Generations;Goals;Heart Diseases;Hybrids;In Vitro;Individual;innovation;interdisciplinary approach;Intracellular Transport;Kinesin;Lead;Life;Malignant Neoplasms;Mechanics;Methods;Microfilaments;Microtubules;Molecular;Molecular Motors;Motility;Motor;Myosin ATPase;novel;optic trap;optical traps;Physiological;Pliability;Polymers;Productivity;protein crosslink;protein function;Proteins;Quartz;reconstitution;Research;Screening procedure;Signal Transduction;single molecule;Site;Structure;System;Techniques;transmission process;treatment strategy;Tubulin;Work

PROJECT_TITLE: Biophysical Mechanisms of Force Transmission in Cytoskeletal Ensembles


ORG_DEPT: CHEMISTRY

PHR: PROJECT NARRATIVE  While fluorinated functional groups have become a hallmark of the modern medicinal chemist’s toolkit, there remain a number of groups – e.g., SF5, N(CF3)2, and N(CF3)(CF2H) – with demonstrated potential that are counterintuitively underemployed. The source of the problem is that all known methods to make these groups require extremely harsh reagents and reaction conditions; that is, the apparent bottleneck in realizing their utility in biological applications is overcoming the vertiginous challenge of chemical accessibility. Accordingly, the proposed research focuses on developing user-friendly synthetic methods to make the SF5, N(CF3)2, and N(CF3)(CF2H) groups more readily available to a broader community of scientists, ultimately to enable downstream applications in drug design.

PI_NAMEs: PITTS, CODY ROSS (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TITLE: Synthetic Methods to Make Emerging Fluorinated Groups More Accessible


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Narrative The goal of the Oncology Research Training Program is to teach MD cancer specialists-in-training the skills necessary to pursue careers in cancer research so that they can contribute to the development of advances in the prevention, diagnosis, and treatment of cancer.

PI_NAMEs: LI, QING  (contact)

PROGRAM_OFFICER_NAME: LIM, SUSAN E

PROJECT_TERMS: Grant;Oncology;Research Training

PROJECT_TITLE: Oncology Research Training Grant

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


NIH_SPENDING_CATS: Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: WEST LAFAYETTE

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: Narrative Interactions between human mesenchymal stem cells (hMSCs) and their environment are a main factor in the function of these cells. During cell-material interactions, there is a feedback loop between environmental cues and hMSC-mediated remodeling of the pericellular region which is poorly understood. The proposed work will use synthetic hydrogel scaffolds to mimic aspects of the native tissue environment to quantitatively characterize the change in 3D encapsulated hMSC processes and dynamic hMSC-mediated pericellular degradation and remodeling to build a fundamental understanding of the role of cell-material interactions and the inﬂuence on basic cellular processes.

PI_NAMEs: SCHULTZ, KELLY M (contact)

PROGRAM_OFFICER_NAME: RIGAS, MARC

PROJECT_TERMS: 3-Dimensional;Adhesions;Black Box;Cell Adhesion;cell motility;Cell Physiology;Cells;Complex;Controlled Environment;Cues;design;Encapsulated;Engineering;Environment;Evolution;experimental study;Feedback;Goals;Human;hydrogel scaffold;in vitro Model;in vivo;ineffective therapies;loss of function;Measurement;Measures;Mediating;Mesenchymal Stem Cells;Modeling;Outcome;particle;pharmacologic;Process;programs;Research;response;Rheology;Role;scaffold;Signaling Molecule;spatiotemporal;Stains;stem cell function;stem cell therapy;Techniques;temporal measurement;three dimensional cell culture;Time;Tissues;Treatment Efficacy;viscoelasticity;Work

PROJECT_TITLE: Characterizing the feedback loop between cells and the pericellular region during cell-material interactions


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Emerging Infectious Diseases;Genetics;Human Genome;Infectious Diseases;Lung;Orphan Drug;Rare Diseases;Tuberculosis

ORG_CITY: SAN DIEGO

ORG_NAME: SAN DIEGO STATE UNIVERSITY

PHR: Despite powerful chemotherapy, Mycobacterium tuberculosis survives in many patients' lungs and causes treatment failure or reemergence of tuberculosis, forcing clinicians into surgical intervention. It is unclear why sputum-based diagnostics fail to predict this outcome. This project aims to determine the underlying causes of diagnostic failure and create a knowledgebase enabling development of more sensitive diagnostics, powerful new antibiotics, and vaccines.

PI_NAMEs: VALAFAR, FARAMARZ  (contact)

PROGRAM_OFFICER_NAME: LACOURCIERE, KAREN A

PROJECT_TERMS: Adherence;Antibiotic Therapy;Antibiotics;Antigens;Automobile Driving;Awareness;Bacillus;Bacteria;bacterial community;Biological;Catalogs;Cells;Characteristics;chemotherapy;Clinical;Communities;comparative;comparative genomics;Day Surgery;Detection;Development;Diagnostic;Differentiation Antigens;Disease;DNA Methylation;drug repurposing;Drug resistance;Drug Tolerance;Elements;Ensure;Epigenetic Process;epigenomics;Excision;Failure;Genes;Genetic Recombination;Genetic Variation;Genome;Genomic approach;genomic biomarker;Genomics;Genotype;Goals;Heterogeneity;Human;human pathogen;Immune;In Vitro;Infection;knowledgebase;Lesion;Liquid substance;Lung;Lung infections;lung lesion;Methods;Methylation;methylation biomarker;methylome;methylomics;mosaic;Mycobacterium tuberculosis;Nature;Necrosis;new therapeutic target;next generation;novel;novel diagnostics;novel therapeutics;novel vaccines;Operative Surgical Procedures;outcome prediction;pathogen;Patient-Focused Outcomes;Patients;Penetration;Persons;Pharmaceutical Preparations;Pharmacotherapy;Phenotype;Population;Predisposition;pressure;Prevalence;Process;prognostic;Protocols documentation;Proxy;rational design;Recurrence;Reporting;Resected;Resistance;resistance mechanism;resistant strain;Sampling;Sequence Analysis;Site;Solid;South Africa;Specific qualifier value;Sputum;superinfection;Technology;Testing;Therapeutic;Time;Transposase;Treatment Failure;Tuberculosis;tuberculosis chemotherapy;tuberculosis diagnostics;tuberculosis treatment;vaccine development;Vaccines;Variant;World Health Organization

PROJECT_TITLE: Undetected Drug resistance and Tolerance in lesions of recurrent TB

STUDY_SECTION: DDR

STUDY_SECTION_NAME: Drug Discovery and Mechanisms of Antimicrobial Resistance Study Section[DDR]


NIH_SPENDING_CATS: Diabetes;Genetics;Nutrition;Obesity

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: NARRATIVE Obesity is an inflammatory condition that remains a universal contributor to type 2 diabetes. During the last grant award cycle, we defined pathways that temper the effects of inflammation on insulin sensitivity in obesity. After the next five years, we will know why certain inflammatory signals couple obesity with type 2 diabetes.

PI_NAMEs: HARTIG, SEAN  (contact)

PROGRAM_OFFICER_NAME: BASU, RAJATAVA

PROJECT_TERMS: Acetates;Adipocytes;Adipose tissue;Adverse effects;Anti-Inflammatory Agents;Aspartoacylase;Award;Binding Proteins;Binding Sites;Body Composition;Body mass index;Brain;carbohydrate metabolism;Carbon;cell type;Chronic;clinical efficacy;comorbidity;Complex;Coupled;cytokine;Cytoplasm;Data;Diabetic mouse;DNA Binding;Educational process of instructing;energy balance;Energy Metabolism;Enzymes;Exposure to;fatty acid metabolism;Feedback;Gene Expression;Genes;Genetic Transcription;Genomics;Goals;Grant;High Fat Diet;Human;Hyperglycemia;IFNGR1 gene;Immune system;Immunotherapy;improved;Inflammation;Inflammatory;Inflammatory Response;insight;Insulin Resistance;insulin sensitivity;Interferon Type II;Knock-out;Knowledge;Link;lipid biosynthesis;lipid metabolism;Lipids;Measures;Mediating;Metabolic;metabolic fitness;Metabolism;metabolomics;Methods;Mitochondria;mitochondrial dysfunction;Molecular;Mus;Non-Insulin-Dependent Diabetes Mellitus;novel;Nutrient;Obese Mice;Obesity;obesity treatment;Oligodendroglia;Outcome;Overnutrition;Oxidative Phosphorylation;Pathogenicity;Pathway interactions;Phenotype;programs;Receptor Signaling;Repression;Research;response;Rodent;Role;Signal Transduction;STAT1 gene;Stress;Testing;Therapeutic;Tissue Expansion;transcription factor;Transcriptional Activation;Transcriptional Regulation;transcriptome sequencing;transmission process;Weight Gain

PROJECT_TITLE: Metabolic Impacts of Type II Interferon Signals in Obesity

STUDY_SECTION: CSME

STUDY_SECTION_NAME: Cell Signaling and Molecular Endocrinology Study Section[CSME]


ADMINISTERING_IC: AG

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: BERKELEY

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: Project Narrative To achieve early detection of Alzheimer’s disease (AD), which is critical for effective intervention, mechanistic models of preclinical AD pathological changes must be more comprehensive, incorporating all regions affected early in AD. The current proposal will use multiple approaches to demonstrate that two key AD-vulnerable regions historically studied separately, the basal forebrain and the entorhinal cortex, are affected similarly by early AD pathology with distinct cognitive consequences. This work will help to uncover drivers of AD-vulnerability in cortical and subcortical regions and to develop a more holistic understanding of preclinical AD, including variability in early cognitive decline.

PI_NAMEs: HARRISON, THERESA M. (contact)

PROGRAM_OFFICER_NAME: HAAKENSON, CHELSEA MARIE

PROJECT_TERMS: Acetylcholinesterase Inhibitors;Address;Affect;Alzheimer disease detection;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Amyloid beta-Protein;Anatomy;Area;Atlases;Atrophic;Automobile Driving;basal forebrain;basal forebrain cholinergic neurons;Biological Markers;Brain;career;causal model;cerebral atrophy;cholinergic;Clinical;Cognition;Cognitive;Cognitive aging;cohort;Communities;community building;comparison control;Data;Data Set;Deposition;Development;Discipline;Disease;Early Diagnosis;effective intervention;Ensure;entorhinal cortex;Environment;Episodic memory;Ethnic Population;experimental study;Faculty;Gene Expression;Genes;Genetic;genetic analysis;Goals;Human;Impaired cognition;innovation;interest;Intervention;K-Series Research Career Programs;Link;Magnetic Resonance Imaging;Measures;Mediating;Memory;Memory Loss;Modality;Modeling;multimodality;neuroimaging;neuroinflammation;novel;older adult;Ontology;Participant;Pathogenesis;Pathologic;Pathology;Pathway interactions;Pattern;Phenotype;Positron-Emission Tomography;pre-clinical;Pre-Clinical Model;Process;programs;racial population;Research;Research Project Grants;Resources;Rest;Role;Side;Site;Structure;Symptoms;Synapses;System;tau aggregation;tau Proteins;Technical Expertise;Temporal Lobe;Testing;Thick;Tracer;Training;training opportunity;Work

PROJECT_TITLE: Linking basal forebrain and entorhinal cortex vulnerability to preclinical Alzheimer's disease

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development For Early Career Investigators Study Section [AGCD-2]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: NARRATIVE The locus coeruleus, a minuscule region in the dorsal pons, is important for cognition and one of the first regions to accumulate pathologic tau proteins. The proposed study aims to apply novel methods in two large-scale longitudinal cohorts to examine whether the patterns of locus coeruleus activity contribute to the propagation of tau from the brainstem to the entorhinal cortex, the first cortical region accumulating tau, and ultimately leading to cognitive decline. This project has important public health implications and is relevant to part of the NIH’s mission as it will provide insight into the mechanisms of propagation of tau pathology during the primitive stages of Alzheimer's disease and can provide new targets for treatment before irreversible damage has occurred.

PI_NAMEs: PROKOPIOU, PROKOPIS CHRISTOU (contact)

PROGRAM_OFFICER_NAME: GRAY, ERIN EMILY

PROJECT_TERMS: abeta accumulation;abeta deposition;Accounting;Affect;Age;age effect;age related changes;age related decline;aging brain;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease risk;Amyloid beta-Protein;animal data;Animal Experimentation;animal imaging;Animals;awake;Axon;Behavior;behavior influence;beta amyloid pathology;Biological Markers;Brain;Brain Stem;Calcium;Cell Nucleus;Cells;Cessation of life;Clinical;Clinical Trials;Cognition;Cognitive;cognitive performance;coping;Data;Deposition;depressive behavior;design;Detection;detection method;Disease;Dorsal;Early Diagnosis;Early Intervention;effective therapy;entorhinal cortex;Epidemic;Equilibrium;Event;Exhibits;Face;Fiber;Fire - disasters;Frequencies;Functional Magnetic Resonance Imaging;Goals;Health;healthy aging;hemodynamics;Human;human imaging;hyperphosphorylated tau;Image;imaging study;Impaired cognition;improved;in vivo;Individual;insight;Interneurons;Intervention;Lateral;Learning;Link;locus ceruleus structure;Longitudinal cohort;Measurement;Measures;medial temporal lobe;Mediating;Memory;Memory Loss;Methodology;Methods;Mission;Modeling;Mydriasis;Names;Neocortex;Neurofibrillary Tangles;neuroimaging;Neurons;neuropathology;Norepinephrine;novel;Older Population;optogenetics;Pathologic;Pathology;Pattern;Phase;Photometry;Physiological;Pontine structure;Positron-Emission Tomography;Process;Public Health;Rattus;Reporting;response;Rest;Rodent;Senile Plaques;sex;Signal Transduction;Source;Stereotyping;Stress;success;Synapses;tau aggregation;tau Proteins;temporal measurement;Testing;Therapeutic;tool;transmission process;United States;United States National Institutes of Health;Work;β-amyloid burden

PROJECT_TITLE: Contribution of locus coeruleus activity patterns on tau deposition in Alzheimer's disease

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


NIH_SPENDING_CATS: Diabetes;Genetics;Prevention;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: NARRATIVE b-cell dysfunction is a key factor in the progression of type 2 diabetes, as well as an unmet treatment need. Studies supported by this grant have led to a reassessment of mechanisms of b-cell failure, and suggested novel alternative approaches to its treatment. Key advances in the last cycle, including the conceptual underpinning that led to the identification of diabetes-enriched islet cell types and master regulatory activities, as well as the discovery of tractable targets for drug development against b-cell failure, offer hope that the disease can be reversed and prompt a strategic reassessment of drug development.

PI_NAMEs: ACCILI, DOMENICO  (contact)

PROGRAM_OFFICER_NAME: HWA, ALBERT J

PROJECT_TERMS: Ablation;Achievement;Affect;aldehyde dehydrogenase 1;Alleles;Automobile Driving;B-Lymphocytes;BACH2 gene;Beta Cell;Biochemical;cell dedifferentiation;Cell Physiology;Cell Reprogramming;cell type;Cells;Characteristics;ChIP-seq;Chromosome 15;Clustered Regularly Interspaced Short Palindromic Repeats;Data;diabetes control;Diabetes Mellitus;diabetes mellitus genetics;diabetic;Diabetic mouse;diabetic patient;Disease;Disease Management;Disparate;drug development;Drug Targeting;Electron Transport Complex III;Endocrine;Enhancers;Ensure;Exercise;experimental study;Failure;flexibility;FOXO1A gene;Functional disorder;Gene Activation;Gene Expression;Genes;Genetic;genetic corepressor;Genetic Epistasis;Genetic Predisposition to Disease;genome wide association study;genome-wide;Glucose;glucose production;Grant;Heterogeneity;HNF4A gene;Hormonal;Human;human disease;Hypoglycemia;improved;inhibitor;insulin secretion;islet;Islet Cell;Islets of Langerhans;Laboratories;Life;Link;Lipids;loss of function;Mediating;Mediator;Metabolic;Metabolic Control;Metabolic Marker;Mitochondria;Modification;mutant;non-diabetic;Non-Insulin-Dependent Diabetes Mellitus;novel;Nutrient;Oxidoreductase;Pancreas;Pathogenicity;Pathway interactions;Patients;pharmacologic;Phenotype;Play;pre-clinical;prediction algorithm;preservation;prevent;Process;progenitor;programs;Protein Isoforms;Pyruvate;Regulation;Repression;Research;Retinaldehyde;Reverse engineering;Role;Signal Transduction;Site;Source;stem cells;stem-like cell;Susceptibility Gene;Systems Analysis;Testing;Therapeutic;therapeutic target;transcription factor;Vitamin D-Binding Protein;Work

PROJECT_TITLE: Mechanisms of Beta Cell Failure

STUDY_SECTION: BMDM

STUDY_SECTION_NAME: Basic Mechanisms of Diabetes and Metabolism Study Section[BMDM]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;HIV/AIDS;Health Services;Infectious Diseases;Mental Health;Social Determinants of Health

PHR: PROJECT NARRATIVE Behavioral HIV research depends on a nuanced understanding of culture and beliefs and calls for a diverse, informed body of researchers, which is currently lacking. This R25 grant application proposes the Fostering Diversity in HIV Research Program that will provide structured career guidance and research mentorship to underrepresented in medicine/public health trainees (residents, post-doctoral fellows, and graduate students); research will address multiple aspects of the HIV continuum of care. The program will also train a dedicated team of mentors with the specific skills needed for effectively supporting these trainees.

PI_NAMEs: HABERER, JESSICA ELIZABETH (contact)

PROGRAM_OFFICER_NAME: KAMATH, SUSANNAH M A

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Adherence;African American;AIDS prevention;antiretroviral therapy;Applications Grants;Area;Behavioral;behavioral and social science;Behavioral Sciences;Belief;Breathing;Cancer Education Grant Program;career;career development;Caring;Chronic Care;Clinical;Cognitive;Collaborations;Communicable Diseases;community based practice;Community of Practice;Competence;Continuity of Patient Care;Cultural Sensitivity;Dedications;design;Discipline of obstetrics;Diverse Workforce;Doctor of Philosophy;doctoral student;Education Projects;Educational Curriculum;Educational process of instructing;Educational workshop;Epidemic;Epidemiology;ethnic diversity;ethnic minority;Ethnic Origin;evidence base;experience;Exposure to;Face;Faculty;Fellowship Program;Fostering;Funding;gender minority;General Hospitals;global health;Goals;graduate student;Grant;Gynecology;HIV;Human immunodeficiency virus test;Immunology;implicit bias;improved;Individual;innovation;Intervention;Investments;K-Series Research Career Programs;Knowledge;Latinx;Manuscripts;Massachusetts;Master of Science;Maternal Health;Measures;Medicine;Mentors;Mentorship;Methods;National Institute of Mental Health;next generation;novel;novel strategies;Outcome;outreach;Paper;Perinatal transmission;Persons;Population;Postdoctoral Fellow;pre-exposure prophylaxis;primary outcome;Productivity;programs;Psychiatry;Public Health;Public Health Schools;Race;racial diversity;racial minority;recruit;Research;Research Activity;Research Personnel;Research Priority;Residencies;satisfaction;Scholarship;Science;Sexual and Gender Minorities;sexual minority;skills;social;Structure;success;Techniques;theories;therapy adherence;tool;Training;Training Programs;unconscious bias;United States National Institutes of Health;Vocational Guidance;Work;Writing

PROJECT_TITLE: Fostering diversity in the next generation of HIV researchers to improve the HIV continuum of care


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Genetics;Stimulant Use and Misuse;Substance Misuse

ORG_DEPT: PSYCHIATRY

PHR: ––– PROJECT NARRATIVE –––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––– Substance use disorders are a chronic human condition where initial consumption leads to long-lasting behavioral changes that are fueled by impulsive choices and changes in motivation, chiefly an increased desire for the abused substance. Substance use is also driven by genetic factors, but what genes underlie impulsivity and changes in motivation are largely unknown. The results from this proposal will isolate genetic factors affecting impulsivity and motivation, thereby illuminating critical mechanisms driving addiction and substance use.

PI_NAMEs: CHOW, CLEMENT ;ROTHENFLUH, ADRIAN  (contact)

PROGRAM_OFFICER_NAME: BORGMANN, KATHLEEN RUTH

PROJECT_TERMS: addiction;Adult;Affect;alcohol and other drug;alcohol response;Amphetamines;Animal Model;Animals;Area;Automobile Driving;Award;Basic Science;Behavior;Behavioral;behavioral response;behavioral study;Biological;Biological Assay;Candidate Disease Gene;cell type;Characteristics;Chronic;Cocaine;Conflict (Psychology);Consumption;cost;Coupled;deprivation;Development;Diagnosis;discounting;Dose;Drosophila genus;Drosophila melanogaster;drug of abuse;Drug user;Economics;Electroconvulsive Shock;endophenotype;Exanthema;experience;experimental study;Experimental Water Deprivation;Face;fly;follow-up;Food;Food deprivation (experimental);food quality;Future;gene conservation;Genes;Genetic;Genetic Models;genetic resource;genome wide association study;Glycoproteins;Goals;Heterogeneity;Human;Impulsivity;Individual;innovation;insight;knock-down;Liquid substance;Maintenance;Measures;Methods;model organism;Modeling;Motivation;Mus;mutant;Nervous System;neurogenetics;Neuroglia;Neurons;Neurotransmitters;novel;Orthologous Gene;Pathway interactions;Pharmaceutical Preparations;Phenotype;Play;Population;preference;programs;psychostimulant;Research;Research Personnel;response;Rewards;Role;Sampling;Self Administration;Serotonergic System;Shock;Societies;Substance abuse problem;substance use;Substance Use Disorder;Sucrose;Techniques;Testing;Time;Tissues;trait;Validation;Variant;vinegar fly;willingness

PROJECT_TITLE: The Genetics of Impulsivity and Motivation


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Data Science;Dementia;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences

ORG_CITY: PROVIDENCE

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: Project Narrative Identification of positron emission tomography (PET) imaging biomarkers for patients with Alzheimer’s disease (AD) that describe brain changes over time is crucial for treatment clinical trials and observational studies of AD. We propose to develop rigorous statistical methods for analyzing multi-modality, high-dimensional longitudinal PET and MRI imaging data for biomarker discovery.

PI_NAMEs: ELOYAN, ANI  (contact)

PROGRAM_OFFICER_NAME: HSIAO, JOHN

PROJECT_TERMS: Alzheimer's Disease;Alzheimer's disease patient;Amyloid;Atrophic;automated algorithm;Bayesian neural network;Binding;Biological;Biological Markers;biomarker discovery;biomarker identification;biomedical imaging;Brain;cerebral atrophy;Clinical;clinical predictors;Clinical Research;Clinical Treatment;Clinical Trials;Cognitive;cognitive performance;Complex;complex data;Data;Data Analyses;Data Collection;deep learning;design;Development;dimension reduction;Dimensions;Disease;disease diagnosis;Disease Progression;drug development;early onset;Epidemiology;Etiology;feature extraction;Future;Goals;high dimensionality;High-dimensional Modeling;Image;imaging modality;Imaging technology;Impaired cognition;improved;independent component analysis;insight;interest;Late Onset Alzheimer Disease;Learning;learning strategy;longitudinal analysis;longitudinal positron emission tomography;Magnetic Resonance Imaging;Mathematics;Measurement;Measures;Mediator;Medical Imaging;Methods;Modeling;Morphology;multimodal data;Multimodal Imaging;multimodality;Nervous System Disorder;neural network;neuroimaging;neuroimaging marker;Noise;novel;novel strategies;Observational Study;Outcome;Output;Participant;Pathology;patient biomarkers;Patients;Physiological;Population;Positron-Emission Tomography;predictive modeling;primary outcome;radiological imaging;radiomics;Research Methodology;Scanning;secondary outcome;Severities;Severity of illness;Shapes;Site;Standardization;Statistical Methods;Statistical Models;statistics;Structure;success;targeted treatment;tau Proteins;Techniques;Technology;Testing;Texture;Time;time interval;tool;Tracer;Uncertainty;uptake;Visit;Visualization

PROJECT_TITLE: High-dimensional Modeling of PET for radiomic Biomarker Discovery

STUDY_SECTION: BMRD

STUDY_SECTION_NAME: Biostatistical Methods and Research Design Study Section[BMRD]


NIH_SPENDING_CATS: Cardiovascular;Congenital Heart Disease;Congenital Structural Anomalies;Genetics;Heart Disease;Pediatric;Rare Diseases

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE Mutations in genes encoding mitochondrial proteins frequently result in congenital heart disease, highlighting the need to elucidate key molecular pathway(s) in mitochondrial homeostasis during heart development. Protein Tyrosine Phosphatase localized to the Mitochondrion 1 (PTPMT1) is a mitochondrial phosphatase, exclusively localized to mitochondria. Proposed studies will help us to understand the biological function of PTPMT1 in cardiomyocytes at the molecular, cellular, and physiological levels, and determine consequences of partial or complete loss of Activating Transcription Factor 4 (ATF4), a master transcriptional regulator of the mitochondrial stress response, on phenotypes of Ptpmt1 cardiomyocyte-specific knockout mice.

PI_NAMEs: CHEN, JU  (contact)

PROGRAM_OFFICER_NAME: SCHRAMM, CHARLENE A

PROJECT_TERMS: activating transcription factor 4;Address;Affect;Apoptosis;Attenuated;Bioinformatics;biological adaptation to stress;Biological Process;calcification;Cardiac;Cardiac Myocytes;cardiogenesis;Cell Cycle Arrest;Cells;congenital heart abnormality;Crista ampullaris;Data;Defect;Development;DNA;Embryo;embryonic stem cell;endoplasmic reticulum stress;Fibroblasts;Genes;Genetic Transcription;Heart;Heart Abnormalities;heart function;Heterozygote;Homeostasis;implantation;in vivo;inhibitor;Inner mitochondrial membrane;insight;Knock-out;Knockout Mice;lipidomics;loss of function;LoxP-flanked allele;Medial;Mitochondria;mitochondrial dysfunction;Mitochondrial Proteins;Modeling;Molecular;Morphogenesis;Morphology;mouse model;Mus;Mutation;Myocardium;novel;Nuclear;Oxygen Consumption;Pathway interactions;Phenotype;phosphatidylglycerophosphate;Phosphatidylinositol Phosphates;Phospholipids;phosphoproteomics;Phosphoric Monoester Hydrolases;Phosphorylation;Physiological;Play;Process;Proliferating;Protein Dephosphorylation;Protein Tyrosine Phosphatase;Respiration;response;Role;senescence;Signal Transduction;Smooth Muscle;Specificity;Stress;Succinate Dehydrogenase;Thinness;transcriptome sequencing;Zebrafish

PROJECT_TITLE: Novel function of a mitochondria phosphatase in cardiac development

STUDY_SECTION: CDD

STUDY_SECTION_NAME: Cardiovascular Differentiation and Development Study Section[CDD]


NIH_SPENDING_CATS: Cancer;Genetics

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

PHR: Project Narrative DNA double-strand break (DSB) repair is critical to maintain genomic stability mending DNA lesions that are induced by ionizing radiation and other common modalities of DNA damage-based anti-cancer therapies including topoisomerase I and II-targeted drugs as well as inhibitors of poly(ADP-ribose) polymerase (PARP). Homologous recombination involving BRCA2, single-strand annealing catalyzed by RAD52, and POLq-mediated end-joining are key cellular pathways for DSB repair. Our mechanistic findings are important for the understanding of the synthetic lethality network of BRCA2-defective cells, and the insights gained will help to stratify tumors that best respond to the inhibition of RAD52, POLq, and/or PARP.

PI_NAMEs: HEYER, WOLF-DIETRICH  (contact)

PROGRAM_OFFICER_NAME: WITKIN, KEREN L

PROJECT_TERMS: Abbreviations;Affect;Base Pairing;Biochemical;Biochemical Reaction;BRCA2 gene;C-terminal;Camptothecin;cancer cell;cancer therapy;Cell Cycle;Cells;Chromosomal Rearrangement;chromosome fusion;chromosome loss;Clinical;clinical application;Complex;Cyclin-Dependent Kinases;Data;Defect;DNA Binding;DNA Binding Domain;DNA biosynthesis;DNA Damage;DNA damage checkpoint;DNA Double Strand Break;DNA lesion;DNA Repair Gene;DNA replication fork;DNA-Directed DNA Polymerase;Double Strand Break Repair;Drug Targeting;Energy Transfer;Filament;Fluorescence;Fluorescence Resonance Energy Transfer;Genes;Genome;Genome Stability;Genomics;Goals;homologous recombination;homologous recombination deficiency;Human;Image;Immune checkpoint inhibitor;In Vitro;Individual;inhibitor;innovation;insight;Ionizing radiation;Knowledge;Length;loss of function;Mediating;Mediator;Mitosis;Modality;Modeling;Mutagenesis;mutant;Nonhomologous DNA End Joining;novel;Pathway interactions;Patient Selection;personalized medicine;Phase;Poly(ADP-ribose) Polymerase Inhibitor;Poly(ADP-ribose) Polymerases;Polymerase;Predisposition;Process;Productivity;Property;protein purification;Proteins;Protocols documentation;Rad51 recombinase;RAD52 gene;Radiation induced damage;Reaction;Reactive Oxygen Species;reconstitution;Regimen;Regulation;repaired;Research;Resistance;response;Role;S phase;Side;Source;Testing;Therapeutic;Topoisomerase II;translational potential;tumor;Type I DNA Topoisomerases

PROJECT_TITLE: Regulation of DNA double-strand break repair pathway choice

STUDY_SECTION: CE

STUDY_SECTION_NAME: Cancer Etiology Study Section[CE]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Digestive Diseases;Drug Abuse (NIDA only);HIV/AIDS;Harm Reduction for Substance Misuse;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Hepatitis;Hepatitis - C;Infectious Diseases;Liver Disease;Prevention;Primary Health Care;Social Determinants of Health;Substance Misuse

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project Narrative People living with HIV (PLWH) who use drugs experience significant health disparities including lower rates of retention in HIV care and higher rates of unsuppressed viral load, resulting in secondary infections and increased mortality. The proposed study will used mixed methods to explore (a) providers’ attitudes towards working with PLWH who use drugs as well as their preparedness for delivering harm reduction care; (b) patients’ experiences of stigma in healthcare settings, viewed from an intersectionality framework; and (c) the extent to which structural and relational harm reduction care buffer the effects of stigma in HIV primary care settings, contributing to improved clinical outcomes. The study will also use these findings to inform the development of an intervention to operationalize harm reduction in healthcare settings, using stakeholder- engaged and human-centered design approaches, presenting a novel path to reducing HIV health inequities for PLWH who use drugs.

PI_NAMEs: HAWK, MARY ELIZABETH (contact);KAY, EMMA SOPHIA

PROGRAM_OFFICER_NAME: ZUR, JULIA BETH

PROJECT_TERMS: acceptability and feasibility;Adherence;Affect;antiretroviral therapy;Area;Attitude;Behavior;behavioral health;Buffers;Buprenorphine;Caring;Characteristics;Clinic;Clinical;Continuity of Patient Care;Data;Drug usage;Drug user;efficacy/implementation trial;Electronic Health Record;empowerment;Evaluation;Exclusion;Exhibits;experience;Harm Reduction;Health;Health behavior;health care settings;health disparity;health inequalities;Health Personnel;Hepatitis C;Hepatitis C co-infection;Hepatitis C Incidence;HIV;HIV/HCV;human centered design;improved;improved outcome;Infection;infection rate;Injecting drug user;injection drug use;intersectionality;Intervention;Interview;lens;Literature;Measures;Medical Care Team;medication compliance;medication for opioid use disorder;member;Methods;Modeling;mortality;multidisciplinary;Needle-Exchange Programs;NIH Office of AIDS Research;novel;Nurses;Online Systems;opioid overdose;Organizational Policy;organizational structure;Outcome;Pathway interactions;patient engagement;Patients;Perception;Persons;Physicians;Policies;Population;Prevention;Primary Care;primary care setting;primary care team;Property;Provider;Psychometrics;Readiness;Research;response;retention rate;Risk;Route;secondary infection;Self Efficacy;Services;Severities;social;social stigma;Social Workers;Stigmatization;Structure;substance use;Substance Use Disorder;substance use treatment;Surveys;Syringes;Testing;therapy adherence;therapy development;transmission process;Viral;Viral Load result;Visit;Work

PROJECT_TITLE: Impact of harm reduction care in HIV clinical settings on stigma and health outcomes for PLWH who use drugs