ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Bioengineering;Infectious Diseases;Lung

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: NARRATIVE: There is an urgent need for finding more effective drug delivery methods and treatments for respiratory tract infections, such as COVID-19. Nitric oxide (NO) gas is an inhalable, extremely potent and FDA approved medicine used to increase oxygen levels of blood and has a very strong antimicrobial effect, but its therapeutic application is very limited due to its very high costs. Herein, we propose to develop a novel, safe and very inexpensive electrochemical method for generating gas phase NO from nitrite solution that can be attached to a noninvasive high flow nasal cannula (HFNC) delivery system for very precise and controlled administration of NO to patients.

PI_NAMEs: LAUTNER, GERGELY  (contact)

PROGRAM_OFFICER_NAME: SHENOY, SIDDHARTH KAUP

PROJECT_TERMS: acute hypoxemic respiratory failure;Acute Respiratory Distress Syndrome;Adult;Air;analytical method;Animals;Antimicrobial Effect;Bacterial Infections;Blood;Breathing;Cannulas;Chronic;Clinical;Clinical Treatment;Clinical Trials;cost;cost effective;Coupled;COVID-19;COVID-19 complications;COVID-19 patient;Custom;Disease;Drug Delivery Systems;endotracheal;Ensure;FDA approved;feasibility testing;Frequencies;Future;Gases;Generations;Goals;health care settings;hemodynamics;High Pressure Liquid Chromatography;Histopathology;Hypoxemia;Hypoxemic Respiratory Failure;improved;improved outcome;In Vitro;in vivo Model;Inductively Coupled Plasma Mass Spectrometry;Inhalation;Inhalation Drug Administration;Inhalation Therapy;inhaled nitric oxide;Intensive Care Units;Intubation;Ions;Local Anti-Infective Agents;Lung;lung failure;Masks;Mass Fragmentography;Mechanical ventilation;Medical;Medicine;Methemoglobin;Methods;Modeling;Monitor;new technology;Nitric Oxide;Nitrites;Nitrogen Dioxide;Nose;novel;operation;Oxygen;Oxygenators;Ozone;Patients;Pattern;Performance;pharmacologic;Phase;porcine model;portability;pre-clinical;prevent;prototype;Pulmonary Fibrosis;Pulmonary Hypertension;Reaction;Refractory;research clinical testing;respiratory;Respiratory Disease;Respiratory distress;Respiratory Tract Infections;Risk;Safety;safety assessment;Sedation procedure;Sheep;sheep model;Sodium Nitrite;Spectroscopy, Fourier Transform Infrared;System;Technology;Testing;Therapeutic;Tidal Volume;Tube;Vasodilator Agents;ventilation;virtual;Virus Diseases;water vapor

PROJECT_TITLE: Electrochemically Generated Inhaled Nitric Oxide (iNO) delivery via High Flow Nasal Cannula (HFNC)

STUDY_SECTION: ISD

STUDY_SECTION_NAME: Instrumentation and Systems Development Study Section[ISD]


ADMINISTERING_IC: CA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Breast Cancer;Cancer;Cancer Genomics;Estrogen;Genetics;Human Genome;Precision Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Women's Health Research

ORG_CITY: MADISON

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE Resistance to endocrine therapy is the major challenge in the management of ER+ BC. Endocrine therapy is designed to target ER in luminal tumors. However, if luminal tumors lose ER expression, a process called “de- differentiation”, tumors lose responsiveness to endocrine therapy, and become resistant. This project aims to understand the underlying molecular mechanism controlling transition from ER+ breast cancers to stem-like cells (SLCs) and target SLCs using epigenetic drugs (i.e., EZH2 inhibitors).

PI_NAMEs: XU, WEI  (contact)

PROGRAM_OFFICER_NAME: MERCER, NATALIA

PROJECT_TERMS: addiction;Adjuvant;Animal Model;Biological Markers;Breast Cancer Cell;Breast Cancer cell line;Breast Cancer Model;Breast Cancer Patient;Catalytic Domain;Cell Fate Control;Cell Line;Cell Maintenance;Cell Proliferation;Cells;Chromatin;Clinical;Clinical Trials;Complex;Data;Deposition;design;Enzymes;epigenetic drug;Epigenetic Process;Estrogen decline;Estrogen receptor negative;Estrogen receptor positive;Estrogen Receptors;Estrogen Therapy;Estrogens;EZH2 gene;FDA approved;Follicular Lymphoma;Gene Expression;Genes;Genetic;Genetic Transcription;genome-wide;Histone H3;histone methylation;Histones;hormone therapy;Human;in vivo;inhibitor;knock-down;Malignant Breast Neoplasm;MCF7 cell;Measures;Methyltransferase;Molecular;mutant;novel therapeutics;Outcome;patient derived xenograft model;Patients;Phenotype;predictive marker;Process;Prognostic Marker;Property;Proteins;receptor expression;Recurrence;Relapse;Resistance;restoration;Role;single cell ATAC-seq;single-cell RNA sequencing;Specimen;stem cells;stem-like cell;Testing;Therapeutic;Transcription Coactivator;transcription factor;triple-negative invasive breast carcinoma;tumor;tumor growth;Writing

PROJECT_TITLE: Ctr9 as a Predictive Biomarker for EZH2 Inhibitor Sensitivity

STUDY_SECTION: CBSS

STUDY_SECTION_NAME: Cancer Biomarkers Study Section[CBSS]


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Bioengineering;Genetics

ORG_CITY: IRVINE

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

ORG_STATE: CA

PHR: PROJECT NARRATIVE Disrupted enhancer activity is associated with a wide variety of pathologies, from congenital disorders to cancer, however, the mechanisms which regulate enhancer activity are still poorly understood. In this proposal, I seek to characterize a newly identified regulatory element that has been shown to be necessary and sufficient for long-range enhancer activity. My findings should provide insight into a new mechanism of gene regulation during development.

PI_NAMEs: BOWER, GRACE CABOT (contact)

PROGRAM_OFFICER_NAME: TOYAMA, REIKO

PROJECT_TERMS: 3-Dimensional;Address;Affect;Architecture;Area;Automobile Driving;Base Pairing;Binding;Bioinformatics;Biological Assay;career development;Cell Nucleus;Chromatin;chromosome conformation capture;Clustered Regularly Interspaced Short Palindromic Repeats;Colon Carcinoma;Communication;Complex;Congenital Disorders;craniofacial disorder;Data;Data Set;design;Development;Developmental Gene;developmental genetics;Disease;Distal;DNA;DNA Sequence;DNA Structure;Elements;Embryo;Enhancers;Environment;Fluorescent in Situ Hybridization;Gene Activation;Gene Expression;Gene Expression Profile;Gene Expression Regulation;Gene Transfer Techniques;Genes;Genetic Enhancer Element;genomic locus;Genomics;Goals;Homeobox;homeodomain;in vivo;insight;Investigation;Knock-out;Limb structure;Link;Malignant Neoplasms;Mediating;Mentors;Methods;Modeling;Multiomic Data;Mus;Mutagenesis;Mutagens;Mutation;novel;Nuclear;Other Genetics;Pathogenesis;Pathology;Play;promoter;Property;Protein Family;Regulatory Element;remote control;Reporter;Research;Resolution;response;Role;superresolution microscopy;System;Technical Expertise;Techniques;Testing;tool;Training;transcription factor;Transgenes;Transplantation;Untranslated RNA;Visualization;Work

PROJECT_TITLE: Characterizing a mechanism of enhancer-promoter interaction in vivo

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-D(21)]


ADMINISTERING_IC: EY

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Eye Disease and Disorders of Vision;Mental Health;Mental Illness;Neurosciences

ORG_CITY: SALT LAKE CITY

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE Humans move their eyes several times a second, and each of these eye movements is accompanied by changes in our visual perception, including distortions of location and duration. The proposed series of electrophysiological, psychophysical, and statistical modeling experiments will identify neuronal changes and brain areas involved in changes in perception around the time of saccades, with direct implications both for understanding normal vision and for disorders involving impaired integration of information across eye movements, such as schizophrenia, attention deficit hyperactivity disorder, dyslexia, and autism spectrum disorders.

PI_NAMEs: NATEGH, NEDA  (contact)

PROGRAM_OFFICER_NAME: FLANDERS, MARTHA C

PROJECT_TERMS: Area;Attention deficit hyperactivity disorder;autism spectrum disorder;Behavioral;Brain;Computer Models;Computing Methodologies;Data;data-driven model;Disease;Dyskinetic syndrome;Dyslexia;Electrophysiology (science);Exhibits;Experimental Models;extrastriate;extrastriate visual cortex;Eye;Eye Movements;frontal eye fields;Generations;Hour;Human;Impairment;insight;Link;Location;Measures;Memory;Mental disorders;Methods;Modeling;Monkeys;Motion;Nature;neural;neural circuit;neural patterning;neuromechanism;Neurons;neurophysiology;nonhuman primate;novel;oculomotor;Parkinson Disease;Perception;pharmacologic;Physiological;Positioning Attribute;Prefrontal Cortex;Process;Psychophysics;Reading;receptive field;response;Retina;retinal imaging;Role;Saccades;Schizophrenia;screening;Sensory;Series;Signal Induction;Source;Statistical Models;Stimulus;System;Techniques;Temporal Lobe;Testing;Time;Vision;Visual;visual information;Visual Motion;Visual Perception;visual processing;visual stimulus;Visual System;Visuospatial

PROJECT_TITLE: Extrastriate Mechanisms of Visuospatial Perception During Eye Movements

STUDY_SECTION: SPC

STUDY_SECTION_NAME: Mechanisms of Sensory, Perceptual, and Cognitive Processes Study Section[SPC]


ADMINISTERING_IC: DK

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Bioengineering;Microbiome;Networking and Information Technology R&D (NITRD);Nutrition;Precision Medicine

ORG_CITY: LA JOLLA

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative The proposed Microbiome and Metagenomics Center is relevant to human health because we anticipate results can be used by the Nutrition for Precision Health Consortium to understand the relationship between the microbiome, nutrition, and human health. Data and technologies developed will be widely available to the community to promote further scientific advances. The Center is relevant to NIH and NIDDK’s mission because it seeks to produce high quality metagenomic and metatranscriptomic data that will help determine how nutrition and the microbiome can be used to improve people’s health and quality of life.

PI_NAMEs: GILBERT, JACK ANTHONY (contact);KNIGHT, ROB

PROGRAM_OFFICER_NAME: MARUVADA, PADMA

PROJECT_TERMS: Acceleration;Address;Agreement;Algorithms;American;Archaea;Area;Artificial Intelligence;Bacteria;Benchmarking;beta diversity;biobank;Bioinformatics;bioinformatics infrastructure;Biological Markers;California;Collaborations;Collection;Communication;Communities;Community Outreach;Computer software;Consensus;Core Facility;cost;Cost efficiency;cost efficient;Data;data access;Data Analyses;data format;data management;Data Provenance;data sharing;data visualization;Dedications;Democracy;density;Detection;detection sensitivity;Development;DNA;Elements;Ensure;Eukaryota;experience;Faculty;Feces;Feedback;Fellowship;Generations;Goals;Health;Human;improved;Infrastructure;innovation;innovative technologies;Institution;interest;International;Investments;Laboratory Research;laptop;Leadership;Libraries;metagenome;Metagenomics;metaproteomics;metatranscriptomics;Microbe;microbial;microbiome;microbiome analysis;microbiome research;Mission;multidisciplinary;National Institute of Diabetes and Digestive and Kidney Diseases;nutrition;Nutritional Study;open source;operation;Participant;Persons;Pilot Projects;Planet Earth;Positioning Attribute;Postdoctoral Fellow;Precision Health;precision nutrition;Preparation;Procedures;Process;Production;Protocols documentation;Quality Control;Quality of life;Recording of previous events;recruit;Reproducibility;Research;Research Design;Research Support;Resolution;RNA;sample collection;Sampling;Scientific Advances and Accomplishments;Scientist;Services;statistics;stool sample;success;Supercomputing;synthetic construct;System;Taxonomy;Technology;Time;tool;ultra high resolution;undergraduate student;United States National Institutes of Health;Universities;Virus;Visualization

PROJECT_TITLE: The UCSD Microbiome and Metagenomics Center


NIH_SPENDING_CATS: Breast Cancer;Cancer;Women's Health Research

ORG_CITY: WASHINGTON

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: GEORGE WASHINGTON UNIVERSITY

ORG_STATE: DC

PHR: Project Narrative Despite CDK4/6 inhibitors significantly improve overall survival of advanced ER+ breast cancer, not all patients respond to these drugs and most patients whose tumors initially respond to CDK4/6 inhibitors eventually develop acquired resistance. In this application, we will determine a novel mechanism regulating resistance to CDK4/6 inhibitors and evaluate effects of potential new drug combination treatments to overcome resistance in ER+ breast cancer. This study can lead to development of an innovative therapeutic strategy for treatment of CDK4/6 inhibitor resistant breast cancer patients.

PI_NAMEs: LI, SHUNQIANG ;MA, CYNTHIA X;ZHU, WENGE  (contact)

PROGRAM_OFFICER_NAME: GREENBERG, WILLIAM A

PROJECT_TERMS: Affect;Aromatase Inhibitors;atovaquone;Breast Cancer Cell;Breast Cancer Patient;Cancer Biology;cancer cell;cancer drug resistance;CDK4 gene;Cell Nucleus;clinical application;Clinical Oncology;Clinical Research;Combined Modality Therapy;Cyclin-Dependent Kinases;Cytoplasm;Data;Development;Disease;Drug Combinations;drug discovery;Drug resistance;Drug Screening;Estrogen receptor positive;FDA approved;follow-up;Gene Expression;glycosylation;improved;In Vitro;in vivo;inhibitor;innovation;Investments;Link;Malignant Breast Neoplasm;Malignant Neoplasms;Mediating;melanocyte;Melanoma Cell;Metastatic breast cancer;migration;Modeling;Molecular;Monosaccharides;mouse model;multidisciplinary;Neoplasm Metastasis;novel;novel drug combination;novel strategies;Nuclear Translocation;O-GlcNAc transferase;Pathway interactions;Patients;Pharmaceutical Preparations;Pharmacotherapy;Physiological;prevent;Proliferating;Protein Conformation;protein function;Protein Isoforms;Proteins;Regulation;Regulatory Pathway;Resistance;resistance mechanism;response;Role;Sampling;senescence;Serine;Signal Transduction;Structure;Testing;Therapeutic;therapy resistant;Threonine;tool;transcription factor;treatment strategy;tumor;virtual

PROJECT_TITLE: Regulation of resistance to CDK4/6 inhibitor in breast cancer

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 1 Study Section[MCT1]


NIH_SPENDING_CATS: Congenital Structural Anomalies;Genetics;Neurosciences;Pediatric;Rare Diseases;Spina Bifida

ORG_NAME: CHILDREN'S RESEARCH INSTITUTE

PHR: PROJECT NARRATIVE Neural tube defects are among the most common structural birth defects and can lead to long-term disability and death. These malformations result from a failure of the flat neural plate to roll into a neural tube during embryogenesis, a complex process involving morphogenesis of not only the neural plate but the underlying cranial mesenchyme. This project aims to elucidate the molecular mechanisms that drive cranial mesenchyme morphogenesis contributing to neural fold elevation.

PI_NAMEs: MORAN, CLAIRE MARIE (contact)

PROGRAM_OFFICER_NAME: KOSTER, MARANKE IRENE

PROJECT_TERMS: Address;Anencephaly;Anterior;Behavior;Bioinformatics;Biological Assay;career;career development;cell behavior;Cell Lineage;cell motility;Cell Surface Receptors;Cells;Cellular biology;cellular imaging;Cephalic;Cessation of life;Child;Client;Complex;Core Facility;Data;Defect;Developmental Biology;differential expression;Doctor of Philosophy;Dorsal;Dyskinetic syndrome;Embryo;embryo tissue;Embryonic Development;Exencephaly;Experimental Genetics;experimental study;extracellular;Extracellular Matrix;Failure;Fibronectins;Foundations;Gene Expression;Genes;Genetic Models;Genetic Transcription;Genomics;Heat-Shock Proteins 90;Image;Image Analysis;In Situ;In Situ Hybridization;In Vitro;innovation;Laboratories;Learning;Light;Long term disability;malformation;Maps;Measures;Mediator;Mentors;Mentorship;Mesenchyme;Metalloproteases;Methods;Microscope;migration;Modeling;Molecular;Molecular Chaperones;Morphogenesis;Motility;mouse genetics;Movement;mutant;mutant mouse model;Mutant Strains Mice;Mutation;Neural Crest;Neural Fold;neural plate;Neural tube;Neural Tube Closure;Neural Tube Defects;novel;Paraxial Mesoderm;Play;Process;Proteins;Publishing;Research Institute;Research Training;Role;Scientist;Shapes;Spinal Dysraphism;Structural Congenital Anomalies;System;Testing;Time;Tissue Expansion;Tissue-Specific Gene Expression;Training;transcriptome sequencing;ubiquitin ligase;Ubiquitination;Validation;Visualization;Work

PROJECT_TITLE: Mechanisms of Abnormal Cranial Mesenchyme Morphogenesis in the Hectd1 mutant


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Genetics;Mental Health;Neurosciences;Pediatric;Social Determinants of Health

ORG_CITY: ITHACA

ORG_DEPT: PSYCHOLOGY

ORG_NAME: CORNELL UNIVERSITY

ORG_STATE: NY

PHR: Project Narrative Neglect, abandonment, abuse, and other forms of early life adversity significantly increase risk for psychiatric disorders, such as depression, by shifting developmental brain trajectories and sensitizing individuals to subsequent stress. This proposal tests the hypothesis that paternal deprivation alters the lateral septum to respond to social stress experienced later in life via neural, epigenetic, and transcriptomic mechanisms that act on the function of the oxytocin and vasopressin systems. This work will contribute to a novel understanding of stress susceptibility and can provide insight to better inform new therapeutic strategies to understand the developmental differences in how sociality is altered by early life adversity.

PI_NAMEs: SAILER, LINDSAY L (contact)

PROGRAM_OFFICER_NAME: MILLER, BRETT

PROJECT_TERMS: 3' Untranslated Regions;Acceleration;Adolescence;Adolescent;Adult;Age;Aggressive behavior;Animal Model;antagonist;avoidance behavior;AVPR1A gene;Behavioral;behavioral phenotyping;biological adaptation to stress;Biological Markers;Birth;Brain;brain behavior;Buffers;Caring;Cells;Child;Chronic;Code;Communication;Complex;coping;Coping Behavior;designer receptors exclusively activated by designer drugs;Development;differential expression;DNA Methylation;early experience;early life adversity;Epigenetic Process;epigenetic regulation;Exhibits;experience;experimental study;Fathers;Female;FOS Protein;Fright;Gene Expression;gene function;gene repression;Genes;Genetic;Genetic Transcription;Individual;insight;late life;Lateral;Life;Life Stress;male;Measures;Mediating;Mental Depression;Mental disorders;Messenger RNA;Methylation;Microtus;Modeling;Modification;mRNA Expression;Mus;neglect;neural;Neurobiology;Neurons;Neuropeptides;neuropsychiatric disorder;neuroregulation;Neurosecretory Systems;novel;novel therapeutic intervention;offspring;Output;Oxytocin;Oxytocin Receptor;Pair Bond;Parent-Child Relations;Paternal Deprivation;Personal Satisfaction;Phenotype;Population;prairie vole;Predisposition;Process;promoter;Promoter Regions;protective effect;protein profiling;receptor expression;Receptor Gene;Reporting;Research;response;Risk;RNA;Rodent;Role;sex;Sex Differences;skills;social;Social Behavior;social defeat;Social Development;social stress;Stress;Stress and Coping;stress resilience;Stressful Event;stressor;System;Testing;Transcriptional Regulation;transcriptomics;Translating;Untranslated RNA;Vasopressin Receptor;Vasopressins;Weaning;Withdrawal;Work

PROJECT_TITLE: Impact of paternal care on stress-coping behaviors and neuropeptide systems


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Dementia;Neurodegenerative;Neurosciences;Palliative Care;Telehealth

ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: PROJECT NARRATIVE Of the 13 million US older adults admitted to the hospital each year, nearly half will require a surrogate decision maker due to Alzheimer’s disease (AD) and other conditions that cause cognitive impairment. The process of decision making and the experiences of the surrogates are therefore central to the care of older adults. Findings from this research will improve the quality of medical decisions for older adults with AD and other causes of cognitive impairment and will improve the well-being of family surrogates.

PI_NAMEs: TORKE, ALEXIA MARY (contact)

PROGRAM_OFFICER_NAME: GERALD, MELISSA S

PROJECT_TERMS: Address;Admission activity;Advance Care Planning;Age;Aging;Alexia;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease related dementia;Amber;Anxiety;Appointment;Asian;Award;Belief;career;Caring;Cessation of life;Chaplain;Clinical;clinical investigation;Clinical Sciences;clinical translation;Communication;Communication difficulty;Country;COVID-19;COVID-19 outbreak;COVID-19 pandemic;Critical Illness;Decision Making;Dementia;Distress;Doctor of Philosophy;early experience;Education;Effectiveness;Emotional;Enrollment;Ethics;Ethnic Origin;experience;Faculty;Family;Family member;family support;Funding;Future;future pandemic;Goals;Grant;Health;Heart failure;Hispanic;Home;Hospitalization;Hospitals;Impaired cognition;improved;Indiana;Infrastructure;innovation;Intervention;intervention delivery;Intervention Studies;K-Series Research Career Programs;Latinx;Learning;Life;Location;Manuscripts;Medical;Medical center;Mental Depression;Mentors;Mentorship;Methods;Midwestern United States;Multicenter Trials;new technology;older adult;Outpatients;Palliative Care;pandemic disease;patient oriented research;Patients;Personal Satisfaction;Persons;Pilot Projects;Population;post-traumatic symptoms;Pragmatic clinical trial;Preparation;Process;programs;Publishing;Race;Randomized, Controlled Trials;Religion;Reporting;Research;Research Methodology;Research Personnel;research study;Research Training;Resources;Risk;Schedule;Skilled Nursing Facilities;Source;Spiritual care;Spirituality;Stress;Stroke;success;surrogate decision maker;surrogate decision making;symposium;Technology;Telephone;telephone delivery;Testing;Time;Translational Research;Universities;Videoconferencing;volunteer;Work

PROJECT_TITLE: Communication in the Hospital: Impact on Patients with Alzheimer's Disease and Other Causes of Cognitive Impairments and their Surrogate Decision Makers

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Behavior and Social Science of Aging Study Section[NIA-S]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Arthritis;Behavioral and Social Science;Bioengineering;Biotechnology;Chronic Pain;Gene Therapy;Genetics;Human Genome;Nanotechnology;Neurosciences;Opioids;Pain Research;Rehabilitation

ORG_CITY: WINSTON-SALEM

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

ORG_STATE: NC

PHR: PROJECT NARRATIVE The development of non-narcotic (non-opioid) therapeutics is urgently needed in light of the current opioid epidemic. Pain that results from surgeries or from arthritis is linked to prolonged inflammation and is typically treated with opiates, which places million of patients with these conditions at higher risks for opioid abuse problems. The proposed studies will validate a specific target to promote a faster resolution of inflammation as a new non-narcotic therapeutic strategy that has the potential to prevent or treat surgical or inflammatory pain.

PI_NAMEs: MARTIN, THOMAS JEFFREY;ROMERO-SANDOVAL, E. ALFONSO (contact)

PROGRAM_OFFICER_NAME: MOHAPATRA, DURGA PRASANNA

PROJECT_TERMS: 3-Dimensional;Acute Pain;addiction;Address;Anti-Inflammatory Agents;Arthritis;Attention;Behavior;Behavior assessment;Behavioral;Bioinformatics;Biological Assay;Cell Reprogramming;Cells;Chronic;Chronic inflammatory pain;chronic pain;chronic pain management;Clinical;clinically relevant;Complementary DNA;Complex;Critical Pathways;cytokine;Data;design;Development;Dimensions;Disease Progression;Dose;Dose Limiting;Drug abuse;Freund's Adjuvant;gain of function;Gene Expression;gene induction;gene-targeted therapy;Genes;genetic signature;Genetic Transcription;genome-wide;high risk;Human;human data;Immune response;Immune system;Immunobiology;Immunologics;improved;Infiltration;Inflammation;Inflammation Mediators;Inflammatory;inflammatory pain;injured;Injury;innovation;insight;Interleukin-1 beta;Intervention;Knee;knock-down;Light;Link;loss of function;Macrophage;Measures;Mechanics;Mediator;Modeling;Molecular;Morphine;multidisciplinary;Muscle;nanoparticle;Nanotechnology;non-opioid analgesic;novel;Nucleic Acids;Operative Surgical Procedures;Opioid;opioid abuse;opioid epidemic;opioid sparing;Outcome;overexpression;Pain;pain behavior;Pain management;pain model;pain reduction;Patients;Peripheral;Pharmaceutical Preparations;Phenotype;Plasmids;Polyethyleneimine;Positioning Attribute;Postoperative Pain;postoperative recovery;prevent;Process;Production;programs;Rattus;Recovery;Recovery of Function;Research;Resolution;response;side effect;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Skin;Skin Tissue;Small Interfering RNA;Speed;Surgical incisions;Surgical Models;surgical pain;Technology;Testing;Therapeutic;therapeutic target;tissue repair;Tissues;TNF gene;tool;transcriptome sequencing;transcriptomics;translational potential;Trauma;Weight-Bearing state;wound;wound healing

PROJECT_TITLE: Cell-directed gene therapy for pain recovery after surgery and inflammation

STUDY_SECTION: NPI

STUDY_SECTION_NAME: Neurobiology of Pain and Itch Study Section [NPI]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cocaine;Drug Abuse (NIDA only);Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: PORTLAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Project Narrative Exposure to cues associated with drugs of abuse can provoke craving and precipitate relapse long after the last drug experience. This reflects an increased ability of these cues to energize behavior, which is a hallmark of dopaminergic activity. Using a rodent model of vulnerability to cocaine relapse after protracted abstinence, I will measure dopamine and test for its functional significance in this behavior.

PI_NAMEs: WEBER, SOPHIA JIAHN (contact)

PROGRAM_OFFICER_NAME: BABECKI, BETH

PROJECT_TERMS: Abstinence;AMPA Receptors;Animal Model;Behavior;Biosensor;Calcium;Clinical;Cocaine;cocaine craving;cocaine exposure;cocaine relapse;cocaine seeking;cocaine self-administration;Complex;craving;Cue-induced relapse;Cues;design;Development;Dopamine;Dopamine Antagonists;Dopamine D1 Receptor;Dopamine D2 Receptor;Dopamine Receptor;dopamine system;drug abstinence;drug of abuse;Environment;experience;Experimental Designs;experimental study;Exposure to;falls;Fellowship;Fiber;Fiber Optics;Fluorescence;Future;Glutamate Receptor;Glutamates;Goals;Home;Human;Implant;improved;Incubated;Individual;Infusion procedures;Knowledge;Learning;Light;Literature;Manuscripts;Measures;Mentors;Modeling;motivated behavior;Motivation;mutant;neuromechanism;Neurosciences;Nose;Nucleus Accumbens;oral communication;Permeability;Pharmaceutical Preparations;pharmacologic;Phase;Photometry;Play;post-doctoral training;Postdoctoral Fellow;Pre-Clinical Model;Procedures;Rattus;receptor;Receptor Activation;Relapse;Reporting;Research Personnel;response;Rewards;Rodent Model;Role;Scientific Advances and Accomplishments;Scientist;Self Administration;sensor;Signal Transduction;skills;Study models;Substance Use Disorder;symposium;Synapses;Synaptic Transmission;Technical Expertise;Techniques;Testing;Time;Training;transmission process;Viral;Work;World Health Organization;Writing

PROJECT_TITLE: The role of nucleus accumbens dopamine in incubation of cocaine craving


NIH_SPENDING_CATS: Digestive Diseases;Liver Disease

ORG_CITY: NEW YORK

ORG_DEPT: GENETICS

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: The proposed studies will help advance our understanding of how heme homeostasis is maintained in the mammalian liver. The knowledge gained may have direct clinical relevance, as it may improve our understanding of the disease pathogenesis of the acute hepatic porphyrias, which are four inherited liver diseases associated with hepatocyte heme deficiency.

PI_NAMEs: YASUDA, MAKIKO  (contact)

PROGRAM_OFFICER_NAME: ROY, CINDY

PROJECT_TERMS: Ablation;Acute;Adult;Aminolevulinic Acid;Biological Process;Candidate Disease Gene;candidate identification;cell type;Cells;clinically relevant;Coculture Techniques;cofactor;cytotoxic;Disease;Endothelial Cells;Enzymes;Equilibrium;Erythrocytes;Feline Leukemia Virus;Funding;Genes;Genetic;Goals;Grant;Health;Heme;heme a;heme biosynthesis;Heme Iron;Hemeproteins;Hemopexin;Hepatic;Hepatic Porphyrias;Hepatocyte;Homeostasis;Hydrophobicity;improved;In Vitro;in vivo;Inherited;Iron;Knockout Mice;Knowledge;Life;Liver;Liver diseases;Macrophage;Maintenance;Mammalian Cell;Mammals;Mediating;Membrane;Molecular;mouse model;Mus;novel;overexpression;Pathogenesis;Pathway interactions;Process;Proteins;Proteomics;receptor;Recycling;RNA Interference;senescence;Signal Transduction;Signaling Molecule;single-cell RNA sequencing;Subgroup;System;Testing;trafficking

PROJECT_TITLE: Mechanisms of Intercellular Heme Homeostasis in Liver

STUDY_SECTION: HTBT

STUDY_SECTION_NAME: Hemostasis, Thrombosis, Blood Cells and Transfusion Study Section[HTBT]


NIH_SPENDING_CATS: Atherosclerosis;Biotechnology;Cancer;Cardiovascular;Heart Disease;Immunotherapy;Precision Medicine;Skin Cancer

ORG_CITY: FARMINGTON

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT

ORG_STATE: CT

PHR: Project Narrative Anti-LAG3 in combination with anti-PD-1 (OpdualagTM) is a new drug to treat skin cancer that belongs to a class of drugs that activate the immune system to target tumors. Our current project will analyze how LAG3 deficiency (a frequent condition in humans associated with high cholesterol and heart attack risk) impacts both beneficial anti-tumor effects as well as adverse cardiovascular pathology in a mouse model for skin cancer.

PI_NAMEs: ADLER, ADAM J;RODRIGUEZ, ANNABELLE  (contact)

PROGRAM_OFFICER_NAME: HARRIS, RAYMOND D

PROJECT_TERMS: Address;Adverse event;Age;anti-CTLA4;anti-PD-1;anti-PD-L1;Antigen Presentation;antitumor effect;Aorta;Autoimmune;autoimmune toxicity;Biological Markers;Biology;biomarker identification;Bone Marrow;cancer immunotherapy;cancer therapy;Cardiovascular Diseases;cardiovascular disorder risk;Cardiovascular Pathology;Cardiovascular system;CD4 Positive T Lymphocytes;cell type;Cells;checkpoint therapy;Cholesterol;Clinical;clinical development;clinically relevant;CTLA4 gene;cytokine;Dendritic Cells;Dimensions;effector T cell;Event;Exhibits;experience;FDA approved;Future;Gene Activation;genome editing;Glean;High Density Lipoprotein Cholesterol;high risk;Human;hypercholesterolemia;Immune;Immune checkpoint inhibitor;Immune system;Immunotherapeutic agent;Immunotherapy;improved;Inflammation;Inflammatory;insight;Interleukin-10;ITGAX gene;Knock-in;Knock-in Mouse;Knock-out;Knockout Mice;Knowledge;Lipids;Lymphocyte Activation;Malignant Neoplasms;Melanoma;Metastatic Melanoma;Modality;Modeling;Monoclonal Antibodies;mortality risk;mouse model;Multi-Ethnic Study of Atherosclerosis;Mus;Myocardial Infarction;Myocarditis;neoplastic cell;Nivolumab;novel;novel therapeutics;Oncology;Participant;Pathologic;patient biomarkers;patient response;patient subsets;Patients;Pharmaceutical Preparations;Plasma;Play;potential biomarker;pre-clinical;predicting response;programmed cell death ligand 1;Proliferating;Protein Deficiency;Proteins;Regulatory T-Lymphocyte;Reporting;Risk;Role;Serious Adverse Event;Skin Cancer;Smoking;T cell infiltration;T cell therapy;T-Lymphocyte;Testing;Therapeutic;therapeutic target;TNF gene;Transplantation;Treatment Efficacy;Treatment outcome;tumor;tumor growth;Tumor Immunity;Unresectable;Variant;vascular inflammation;virtual;Wild Type Mouse

PROJECT_TITLE: Understanding how the interaction between Lag3 deficiency and hypercholesterolemia impact anti-tumor immunity and cardiovascular disease in a melanoma model


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Cancer Genomics;Genetics;Human Genome;Women's Health Research

ORG_CITY: DALLAS

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: Project Narrative/Relevance Understanding the molecular mechanisms that drive cancer formation and responses to therapeutic interventions will improve our ability to diagnose and treat cancer, which is one of the leading causes of death in the U.S. We have proposed an integrative set of studies that will provide new information about the role of transcription factor ADP-ribosylation by nuclear PARPs in breast cancers, as well as their role in determining the unique biology and therapeutic responses of different breast cancer subtypes to PARP inhibitors. We anticipate that these studies will suggest new avenues for the therapeutic potential of PARP inhibitors in cancers beyond DNA repair pathways.

PI_NAMEs: KRAUS, WILLIAM LEE (contact)

PROGRAM_OFFICER_NAME: LIU, ZHIHUI

PROJECT_TERMS: Address;ADP ribosylation;ADP-Ribosylation Factors;Affect;analog;Biochemical;Biological Assay;Biology;brca gene;Breast Cancer Cell;Cancer Biology;cancer cell;cancer heterogeneity;cancer subtypes;cancer type;Cause of Death;Cell Culture Techniques;cell type;Cells;Clinical;clinically relevant;cohort;computational pipelines;Data;data integration;Diagnosis;DNA Binding;DNA Repair;DNA Repair Pathway;drug discovery;Enhancers;Enzymes;epigenomics;ESR1 gene;Exhibits;Family;FDA approved;Gene Activation;Gene Expression;Gene Expression Profile;Gene Expression Regulation;Genetic Enhancer Element;Genetic Transcription;Genomics;Growth;improved;inhibitor;inhibitor therapy;insight;Invaded;Malignant Breast Neoplasm;Malignant Neoplasms;Maps;Mediating;Methods;migration;Modeling;Molecular;molecular subtypes;Monitor;Mus;Mutate;Mutation;Neoplasm Metastasis;Nuclear;Outcome;Patients;Phenotype;Play;Polymerase;Post-Translational Protein Processing;Process;Proliferating;Proteins;Proteome;Proteomics;Regulation;response;Role;Sampling;Site;Testing;Therapeutic;Therapeutic Intervention;transcription factor;Transcriptional Regulation;treatment response;tumor;Xenograft procedure

PROJECT_TITLE: Role of Transcription Factor ADP-ribosylation in Breast Cancer Biology

STUDY_SECTION: CG

STUDY_SECTION_NAME: Cancer Genetics Study Section[CG]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Autoimmune Disease;Bioengineering;Biotechnology;Diabetes;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Embryonic - Human;Transplantation

ORG_DEPT: BIOMEDICAL ENGINEERING

PHR: PUBLIC HEALTH RELEVANCE The presence and function of vasculature is critical to the success of islet cell replacement therapies for type I diabetes that utilize hydrogel-based scaffolds. The proposed work will use novel techniques to control hydrogel structure with the goal of driving the controlled formation of vasculature around stem cell-derived pancreatic islets. Results from the proposed studies will improve the survival and function of engineered pancreatic islet grafts and help bring these emerging technologies closer to a translational endpoint.

PI_NAMEs: BAKER, BRENDON M (contact)

PROGRAM_OFFICER_NAME: FEHR, TUBA HALISE

PROJECT_TERMS: Address;Adhesives;Adopted;angiogenesis;Artificial Endocrine Pancreas;Automobile Driving;Beds;Behavior;Biocompatible Materials;Blood Vessels;cell motility;Cell Physiology;Cell Proliferation;cell replacement therapy;Cells;clinical translation;Confocal Microscopy;crosslink;Cues;Decision Making;density;design;Diabetic mouse;Emerging Technologies;Endothelial Cells;Endothelium;Engineering;Engraftment;Equilibrium;Event;Fatty acid glycerol esters;Fiber;Geometry;Glucose;Goals;graft function;Graft Survival;Hydrogels;Implant;implantation;improved;In Vitro;in vitro Model;in vivo;in vivo Model;Insulin;Insulin-Dependent Diabetes Mellitus;Invaded;Investigation;islet;Islet Cell;Islets of Langerhans;Kinetics;Lead;Mechanics;Mediating;Mesenchymal;Metabolic;Methods;migration;Modeling;Modulus;mouse model;Mus;nanoscale;novel;Nutrient;Organoids;Oxygen;Phenotype;Porosity;porous hydrogel;Postoperative Period;programs;Proliferating;Property;public health relevance;Regulation;Replacement Therapy;response;Role;scaffold;Series;Site;spatiotemporal;Specific qualifier value;stem cells;Streptozocin;Structure;success;Techniques;Technology;Testing;Tissue Model;tissue repair;Tissues;trait;Transplantation;type I diabetic;Vascular blood supply;Work

PROJECT_TITLE: Angiogenic hydrogel composites for microvascular integration of organoid grafts

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]


ORG_CITY: ATLANTA

ORG_DEPT: PHARMACOLOGY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative Inflammation of the brain accompanies many chronic neurologic disorders including epilepsy. A major inflammatory pathway, that mediated by activation of the EP2 receptor for prostaglandin E2, appears to exert a dual role during the development of epilepsy, both promoting and opposing neuropathology. We will identify the cell types underlying these opposing roles with the aim of developing more targeted anti-inflammatory therapies.

PI_NAMEs: VARVEL, NICHOLAS  (contact)

PROGRAM_OFFICER_NAME: LEENDERS, MIRIAM

PROJECT_TERMS: Ablation;Address;Agonist;Amygdaloid structure;Animal Model;antagonist;Anti-Inflammatory Agents;Antiepileptogenic;Appearance;Astrocytes;Autoimmune;Behavioral Assay;beta-arrestin;Biology;Blood - brain barrier anatomy;Brain;Brain Injuries;butaprost;Cell Survival;cell type;Cells;Chronic;Cognitive deficits;Convulsants;Coupled;Cre driver;CX3CL1 gene;Cyclic AMP;Cyclic AMP-Dependent Protein Kinases;cyclooxygenase 2;cytokine;Development;Dimensions;Dinoprostone;Disease;Electroencephalography;Elements;Encephalitis;Epilepsy;Epileptogenesis;Event;excitotoxicity;Fractalkine;Frequencies;genetic approach;Hemin;Hippocampus;Hour;Human;In Vitro;in vivo;Incidence;Induced Neurons;Infection;Infiltration;Inflammation;Inflammatory;Interleukin-6;Interruption;Invaded;kainate;Knock-out;Ligands;man;Mediating;Membrane;Microglia;Modeling;Modification;Molecular;monocyte;Mus;Myelogenous;Myeloid Cells;N-Methylaspartate;Nerve Degeneration;Nervous System Disorder;neuroinflammation;Neuronal Injury;Neurons;neuropathology;neuroprotection;neurotoxicity;novel;Open Reading Frames;Oral;Outcome;Pathway interactions;Peptides;pharmacologic;Pilocarpine;Play;prevent;primary outcome;Process;Prosencephalon;Prostaglandin E Receptor;Prostaglandin Receptor;Proteins;Quantitative Reverse Transcriptase PCR;Reaction;receptor;Reporting;Rodent;Role;Seizures;Series;Status Epilepticus;Technology;Testing;Transgenes;virtual;Western Blotting;Work

PROJECT_TITLE: Exploiting EP2 receptor biology to target seizure-related neuroinflammation selectively

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;HPV and/or Cervical Cancer Vaccines;Immunization;Infectious Diseases;Pediatric;Prevention;Sexually Transmitted Infections;Social Determinants of Health;Vaccine Related

ORG_CITY: PHILADELPHIA

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Narrative This project seeks to address misinformation on social media contributing to vaccine hesitancy and low rates of HPV vaccine uptake among adolescents. Achieving the goals of this project has the potential to both improve HPV vaccine uptake in the US and provide replicable methods for rapidly identifying and correcting misinformation surrounding other public health concerns such as COVID19 or childhood vaccinations.

PI_NAMEs: KORNIDES, MELANIE LYNN (contact)

PROGRAM_OFFICER_NAME: VANDERPOOL, ROBIN CLINE

PROJECT_TERMS: 11 year old;Address;Adolescent;Age;arm;Attitude;Belief;booster vaccine;cancer prevention;Child;Childhood;Communication;comparative efficacy;Control Groups;COVID-19;Data;Deception;Education;efficacy evaluation;efficacy testing;English Language;Enrollment;Environment;Exposure to;Facebook;falls;Female;financial incentive;follow-up;Fostering;Frequencies;Geographic Locations;Goals;Health;Health behavior;Hearing;HPV vaccine acceptance;Human Papilloma Virus Vaccination;Human Papilloma Virus Vaccine;Human Papillomavirus;improved;Individual;Industry;Injury;innovation;Intervention;male;Media Campaign;media use;Methods;Misinformation;Movement;Natural Language Processing;novel strategies;pandemic disease;Parents;Participant;Prevention;Prevention strategy;primary outcome;Protocols documentation;Public Health;Randomized;Randomized, Controlled Trials;rapid technique;recruit;Recruitment Activity;Reporting;Risk;Safety;Sampling;Screening for cancer;Series;sex;side effect;social media;Surveys;Testing;theories;three-arm study;TikTok;tool;treatment strategy;Tube;Twitter;United States;unvaccinated;Vaccinated;Vaccination;vaccine acceptance;vaccine hesitancy;vaccine refusal;Vaccines;Vendor;Work

PROJECT_TITLE: An inoculation theory-based messaging intervention addressing misinformation about HPV vaccine on social media: The Inoculate for HPV Vaccine randomized controlled trial

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-V(90)]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Genetics;Hematology;Human Genome;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: PROJECT NARRATIVE The myelodysplastic syndromes (MDS) are a group of blood cancers which reduce the ability of the bone marrow to produce normal blood cells while increasing the risk of patients developing a related aggressive form of blood cancers. While a lot has been learned about how mutations alter hematopoietic stem cells to drive MDS development, our ability to analyze the cells responsible for initiation of MDS has been hampered by the fact that these cells are rare in number, which presents a technical challenge for their study. In this proposal we will focus on identifying the abnormalities in DNA, RNA, and protein level within individual cells from the bone marrow of MDS patients, to provide our first ever look into how mutations in MDS perturb each individual cell to drive disease.

PI_NAMEs: ABDEL-WAHAB, OMAR ;LANDAU, DAN  (contact)

PROGRAM_OFFICER_NAME: BAI, C BRIAN

PROJECT_TERMS: Address;Admixture;Adopted;Affect;Automobile Driving;Bar Codes;Blood Cells;Blood typing procedure;bone cell;Bone Marrow;Cell Physiology;Cell surface;cell type;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Characteristics;Chromatin;chromatin modification;Clonal Expansion;cohort;Complementary DNA;Data;Development;Disease;DNA;driver mutation;Dysmyelopoietic Syndromes;Epigenetic Process;Erythroid;Frequencies;Gene Expression;Genetic;Genetic Transcription;Genomics;Genotype;Growth;Hematological Disease;Hematology;Hematopoiesis;Hematopoietic;hematopoietic differentiation;Hematopoietic Neoplasms;Hematopoietic stem cells;Human;Individual;insight;interest;Knowledge;Lead;Learning;Length;Lesion;Link;Maps;Mediating;Methods;methylome;Minority;mouse model;multiple omics;mutant;Mutate;Mutation;mutational status;Nature;Patients;Pattern;Phenotype;Play;progenitor;programs;protein expression;Protein Isoforms;Proteins;Recurrence;Resolution;Risk;RNA;RNA analysis;RNA Splicing;RNA-Binding Proteins;Role;Sampling;self-renewal;Signal Transduction;single cell ATAC-seq;single cell genomics;single cell technology;single-cell RNA sequencing;Somatic Mutation;Spliceosomes;stem cell population;System;Techniques;Technology;Testing;transcriptome;Trees;Validation;Variant

PROJECT_TITLE: Charting the differentiation topology of SF3B1 mutated clonal hematopoiesis (CH) and myelodysplastic syndromes (MDS) via a multi-omics single-cell toolkit

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-VH-C(02)M]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics;Prevention

ORG_CITY: GALVESTON

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

PHR: In humans, mutations in ATR cause Seckel syndrome, characterized by growth retardation and other aging features. The elucidation of ATR’s roles in TLS process in preventing DNA damage induced mutagenesis, chromosomal instability, and apoptotic cell death, will be important for understanding how these ATR roles contribute to genome stability and cellular homeostasis, and aid in protection against aging.

PI_NAMEs: PRAKASH, SATYA  (contact)

PROGRAM_OFFICER_NAME: REDDY, MICHAEL K

PROJECT_TERMS: Active Sites;adduct;adverse outcome;Aging;Apoptotic;Base Excision Repairs;Base Pairing;Biochemical;BRCT Domain;Carcinogens;Cell Death;Cell Physiology;Cells;Chromosomal Instability;Chromosome abnormality;Complex;DNA;DNA Adducts;DNA biosynthesis;DNA Damage;DNA lesion;DNA replication fork;DNA-Directed DNA Polymerase;Genetic;Genetic study;Genome Stability;Genomic Instability;Genomics;Growth;Homeostasis;Human;Impairment;irradiation;Kinetics;Lesion;Link;Mediating;Molecular Conformation;Mutagenesis;Mutation;novel;Nucleotide Excision Repair;nucleotide metabolism;Nucleotides;Pathway interactions;Phosphorylation;Phosphotransferases;Play;pollutant;Polymerase;prevent;Prevention;Process;Purines;Pyrimidine Dimers;Reaction;reconstitution;replication stress;restraint;Role;scaffold;Seckel syndrome;Site;Specificity;Structure;tumorigenesis;ubiquitin ligase;Ubiquitination;ultraviolet lesions;UV induced

PROJECT_TITLE: Impact of ATR's role in translesion synthesis on prevention of DNA damage induced mutagenesis and chromosomal instability

STUDY_SECTION: MG

STUDY_SECTION_NAME: Molecular Genetics Study Section[MG]


ADMINISTERING_IC: NR

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Biotechnology;Cancer;Cancer Genomics;Clinical Research;Colorectal Cancer;Digestive Diseases;Genetics;Human Genome;Nutrition;Physical Activity;Precision Medicine;Prevention;Sleep Research

ORG_CITY: LOS ANGELES

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

PHR: PROJECT NARRATIVE Fatigue is a persistent problem affecting up to 90% of cancer patients, yet treatment options are limited. Advances in metabolomics and genomics offer an unprecedent opportunity to unravel the underlying biological mechanisms and to identify novel biomarkers of fatigue, which may be targets for therapeutic intervention. We will use the 3-P (Predisposing, Precipitating, Prepetuating) model to combine genomics, metabolomics, inflammatory markers and behaviors to comprehensively examine contributors of cancer- related fatigue in ColoCare, a large cohort of colorectal cancer patients.

PI_NAMEs: FIGUEIREDO, JANE C. (contact);JIM, HEATHER S.L.

PROGRAM_OFFICER_NAME: TYUS, NADRA

PROJECT_TERMS: Adherence;Affect;Aftercare;Age;Behavior;Behavioral;Behavioral Mechanisms;biobehavior;Biological;biological sex;Biology;Blood specimen;Cancer Biology;cancer biomarkers;Cancer Etiology;Cancer Patient;Cancer Survivor;Catabolism;Ceramides;Characteristics;chemotherapy;Chronic;Chronic Fatigue Syndrome;Circadian Dysregulation;Circadian Rhythms;Clinical;cohort;Cohort Studies;Collaborations;colon cancer patients;Colorectal Cancer;comorbidity;Complex;cytokine;Data;Diagnosis;Diet;Energy Metabolism;Epidemiology;Evaluation;Exercise;experience;Fatigue;Functional disorder;Genes;genetic variant;Genetic Variation;Genome;genomic variation;Genomics;Guidelines;high risk;Individual;Inflammasome;Inflammation;Inflammatory;inflammatory marker;innovation;International;Intervention;Life;lipid mediator;Malignant Neoplasms;Measures;Mediating;Metabolic;Metabolic Pathway;Metabolism;metabolome;metabolomics;Modeling;multiple omics;National Comprehensive Cancer Network;Neurosecretory Systems;novel marker;novel strategies;Omega-3 Fatty Acids;Operative Surgical Procedures;Pathway interactions;Patient Self-Report;Patients;Pattern;personalized medicine;Physical activity;physical inactivity;Precipitating Factors;Predisposing Factor;Predisposition;Prevention;Production;prospective;psychosocial;Quality of life;Recommendation;Reporting;Research;risk prediction;Ritalin;Role;Science;Site;Sleep;Sleep disturbances;small molecule;Survivors;survivorship;Symptoms;System;targeted treatment;Technology;Therapeutic Intervention;Time;Treatment-Related Cancer;Tryptophan;Unhealthy Diet;uptake;Work

PROJECT_TITLE: Novel Biomarkers for Cancer-Related Fatigue: Integrating Metabolomics, Genomics and Behaviors

STUDY_SECTION: CHSB

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology B Study Section[CHSB]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Depression;Major Depressive Disorder;Mental Health;Mental Illness;Neurodegenerative;Neurosciences;Serious Mental Illness

ORG_CITY: SAINT LOUIS

ORG_DEPT: NEUROLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Our overall long-term goal is to accurately identify who is at risk of decline in driving, to forecast when decline will occur, and to intervene before decline, thereby reducing the numbers of crashes, injuries, and death in older adults. By 2050, 1 in 4 drivers will be 65 or more years of age, and currently, motor vehicle crashes are a leading cause of injury and death in older adults, with depression and symptomatic Alzheimer disease (AD) independently increasing the risk of a crash. Driving data continuously collected from the natural environment are needed to more accurately evaluate daily behavior and can allow us to determine how preclinical AD, depression, and antidepressant use affect driving decline and crash risk over time.

PI_NAMEs: BABULAL, GANESH M (contact)

PROGRAM_OFFICER_NAME: HARRELL, ERIN

PROJECT_TERMS: Acceleration;Accelerometer;Affect;Age Years;Aging;aging brain;Alzheimer's Disease;Alzheimer’s disease biomarker;Amyloid;amyloid imaging;anti-depressive agents;Area;Automobile Driving;Behavior;Biological Markers;Biostatistical Methods;Cerebrospinal Fluid;Cessation of life;Clinical;Cognition;Cognitive;cohort;Data;Dementia;depressive symptoms;Destinations;Diagnosis;Disease Progression;driving behavior;driving performance;Enrollment;Environment;Evaluation;Event;Exclusion Criteria;Exhibits;follow-up;Goals;Habits;Health;health care availability;human old age (65+);Image;imaging biomarker;Individual;Infrastructure;Injury;International;Interview;Knowledge;Left;Licensing;longitudinal, prospective study;Major Depressive Disorder;Measures;Mental Depression;Methodology;Motor;multidisciplinary;neuroimaging marker;neuropsychiatry;Neuropsychological Tests;older adult;older driver;Outcome;Participant;Patient Self-Report;Patients;Persons;Pharmaceutical Preparations;Population;pre-clinical;Proxy;Psychometrics;Questionnaires;Recording of previous events;recruit;Research;Risk;Risk Behaviors;Safety;self-reported depression;social engagement;Speed;Standardization;synergism;System;tau Proteins;Testing;Time;trend;United States;unsafe driving;Vehicle crash;Visit

PROJECT_TITLE: The Impact of Depression and Preclinical Alzheimer Disease on Driving Among Older Adults


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Genetics;Human Genome;Infertility;Prevention

ORG_CITY: MANHASSET

ORG_NAME: FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH

PHR: PROJECT NARRATIVE Recent progress in complex trait genetics, coupled with the technical ability to generate accurate genome-wide genotypes from single-cell input, has made it possible to genetically screen embryos for common polygenic traits and disease risk. However, little empirical work has been done to quantify the utility of polygenic embryo screening (PES), examine its ethical implications, and assess stakeholder perspectives. The proposed study is designed to provide the necessary empirical basis for informed ethical discussion.

PI_NAMEs: CARMI, SHAI ;LAZARO-MUNOZ, GABRIEL ;LENCZ, TODD  (contact)

PROGRAM_OFFICER_NAME: LOCKHART, NICOLE C

PROJECT_TERMS: Alleles;Aneuploidy;Assisted Reproductive Technology;Attitude;Cells;clinical application;Complex Genetic Trait;Confidence Intervals;Coupled;Data;Data Set;Decision Making;design;Diabetes Mellitus;Disease;disorder risk;Embryo;Endocrinologist;Ethical Analysis;ethical, legal, and social implication;Ethics;evidence base;Future;General Population;genetic counselor;genome-wide;Genotype;Heart Diseases;Height;Individual;Industry;Intelligence;interest;Interview;Investigation;Knowledge;Malignant Neoplasms;Mendelian disorder;Mental disorders;Methodology;Modeling;Motivation;natural Blastocyst Implantation;Noise;Outcome;Partner in relationship;Patients;Phase;pleiotropism;Policy Maker;polygenic risk score;Polygenic Traits;preference;Preimplantation Diagnosis;prenatal;Prevalence;Privatization;Property;Publishing;Reporting;reproductive;Reproductive Medicine;Research;Research Project Grants;Risk;Risk Reduction;screening;Screening procedure;Services;Shapes;simulation;stakeholder perspectives;Stigmatization;Surveys;Technology;theories;Time;trait;Uncertainty;willingness;Work

PROJECT_TITLE: Polygenic Embryo Screening: Towards Informed Decision-Making


NIH_SPENDING_CATS: Aging;Estrogen;Genetics;Human Genome;Neurosciences;Women's Health Research

ORG_CITY: TUCSON

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: Public Health Statement Nationally and globally the aging population continues to grow. In the US and elsewhere, the predominant face of aging will be female as aged women will outnumber men by two to one. Understanding how estrogen, the predominant feminizing hormone, acts to promote and sustain the energy producing system of the brain is critical to revealing changes that occur in the aging female brain that can increase the risk of age-associated neurodegenerative diseases in postmenopausal women such as Alzheimer's, depression and multiple sclerosis.

PI_NAMEs: BRINTON, ROBERTA EILEEN (contact)

PROGRAM_OFFICER_NAME: BARRETT, PAUL JOHN

PROJECT_TERMS: Address;age related;age related neurodegeneration;aged;Aging;aging brain;aging population;Alzheimer's Disease;Bioenergetics;Brain;brain control;cell growth regulation;Cell membrane;Cell Nucleus;cell type;Clinical;clinically significant;Cytoplasm;Data;design;disorder risk;Elements;Energy Metabolism;ESR1 gene;Estradiol;Estrogen decline;Estrogen Receptor 2;Estrogen Receptors;estrogenic;Estrogens;Face;Feedback;Female;Feminization;functional outcomes;Gene Expression;Gene Expression Profile;Generations;Genetic Transcription;Genomics;Glucose;glucose metabolism;glucose transport;Goals;GPER gene;Hormones;IGF1 gene;insight;Insulin;men;Menopause;Mental Depression;Metabolic;Mitochondria;mitochondrial genome;Monitor;Multiple Sclerosis;Nervous System Disorder;Neurologic;Neurons;Nuclear;Outcome;Oxidation-Reduction;Pathway interactions;Pattern;Performance;Perimenopause;Post-Transcriptional Regulation;Postmenopause;Prevalence;Process;programs;Protein Isoforms;Public Health;Regulation;Regulatory Pathway;reproductive;Research;Respiration;response;Risk;Role;Series;Signal Transduction;Starvation;System;Systems Biology;Testing;therapeutic target;Time;Transcriptional Regulation;Woman;Women's Health

PROJECT_TITLE: Aging and Estrogenic Control of the Bioenergetic System in Brain

STUDY_SECTION: ASG

STUDY_SECTION_NAME: Aging Systems and Geriatrics Study Section[ASG]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Autism;Brain Disorders;Depression;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Mental Health;Mental Illness;Neurosciences;Prevention;Schizophrenia;Serious Mental Illness

ORG_CITY: BALTIMORE

ORG_NAME: LIEBER INSTITUTE, INC.

ORG_STATE: MD

PHR: Project Narrative Converging evidence suggests that impairments in the formation or maintenance of synapses that are localized to specific cortical layers may be involved in schizophrenia and other debilitating brain disorders. In this application, we propose to generate transcriptome-scale spatial maps of the human DLPFC to identify layer-specific and cell type-specific expression associations to the molecular causes and consequences of prevalent neuropsychiatric disorders.

PI_NAMEs: MARTINOWICH, KERI  (contact)

PROGRAM_OFFICER_NAME: PRICE, AMANDA JOY

PROJECT_TERMS: Aging;Area;autism spectrum disorder;Autopsy;Biological Assay;Brain;Brain Diseases;Brain region;brain tissue;Cell Count;Cell Nucleus;cell type;Cells;Data;Data Analyses;depressive symptoms;Development;differential expression;Dissection;Freezing;Gene Expression;Genes;Genetic Risk;Genetic Transcription;Genetic Variation;Genome Mappings;genome wide association study;Genomics;Histologic;Histology;Human;Image;imaging Segmentation;Immunofluorescence Immunologic;Impairment;In Situ Hybridization;Individual;Maintenance;Maps;Measurement;Measures;Mental disorders;Molecular;Molecular Profiling;Morphology;Neocortex;neocortical;Neurons;Neuropil;neuropsychiatric disorder;Patients;Pattern;Physiology;Play;Population;Prefrontal Cortex;Prevention;Process;Quantitative Trait Loci;Resolution;Risk;risk variant;RNA;Role;Sampling;Schizophrenia;schizophrenia risk;Signal Transduction;single nucleus RNA-sequencing;Specificity;Spottings;Structure;Synapses;Techniques;Tissues;transcriptome;transcriptome sequencing;transcriptomics;white matter;Work

PROJECT_TITLE: Laminar dissection of cortical human brain gene expression in neuropsychiatric disorders

STUDY_SECTION: PMDA

STUDY_SECTION_NAME: Pathophysiological Basis of Mental Disorders and Addictions Study Section[PMDA]


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Data Science;Genetics;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurofibromatosis;Neurosciences;Pediatric;Precision Medicine;Prevention;Rare Diseases

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

PHR: Project Narrative This study will utilize a set of artificial intelligence methods to evaluate large quantities of data derived from individuals with Neurofibromatosis Type 1 (NF1), a complex genetic disease with the potential to affect every organ system, in order to develop clinical decision support tools that can predict disease risk at the individual patient level. The knowledge gained from such studies will enable physicians and patients (or their family members) to better manage the treatment of NF1 over a lifespan, thus increasing the timeliness and safety of care, as well as the quality of life of those individuals and their care providers. Further, given the similarity of NF1 to many other diseases that involve a complex interaction of genes, clinical features, and other measurable characteristics, the methods we develop should be applicable to a broad variety of conditions beyond NF1 and improve our ability to deliver precision medicine, with ensuing benefits in terms of the costs, quality, and outcomes of healthcare.

PI_NAMEs: GUPTA, ADITI  (contact);PAYNE, PHILIP R.O.

PROGRAM_OFFICER_NAME: LEE, CRYSTAL ANNE

PROJECT_TERMS: Adult;Affect;Algorithms;Artificial Intelligence;artificial intelligence method;Attention deficit hyperactivity disorder;Automobile Driving;autosome;Behavioral;behavioral phenotyping;Benign;Biological Markers;Biological Models;Birth;Body System;burden of illness;care outcomes;care providers;Caring;Central Nervous System;Characteristics;Child;Clinical;Clinical Data;clinical database;clinical decision support;clinical decision-making;clinical heterogeneity;Clinical Markers;clinical phenotype;clinical research site;clinically actionable;Collaborations;comparative;Complex;cost;Data;data harmonization;Data Set;deep learning;Development;Diagnosis;Disease;Disease Management;disease phenotype;disease prognosis;Disease Surveillance;disorder risk;Electronic Health Record;electronic structure;Environment;Ethnic Origin;Family;Family member;gene interaction;Genetic Diseases;Germ-Line Mutation;Glioma;Healthcare Systems;improved;Individual;individual patient;Informatics;Inherited;insight;Institution;inter-individual variation;interest;Knowledge;life span;Machine Learning;machine learning model;Malignant - descriptor;Manuals;Measurable;Measures;Methods;Modeling;Morbidity - disease rate;multiple data sources;multiscale data;Neurofibromatoses;Neurofibromatosis 1;NF1 gene;novel;Optics;Outcome;Pathway interactions;Patients;Pattern;Pediatric Hospitals;Performance;Peripheral Nervous System Neoplasms;Phenotype;phenotyping algorithm;Physicians;point of care;Population;precision medicine;predictive modeling;predictive tools;Predisposition;Preventive measure;prognostic;Prognostic Marker;Psychometrics;Quality of life;Race;Registries;Reproducibility;Research;response;Risk;Risk Assessment;risk stratification;Safety;scoliosis;sex;Site;Structure;structured data;success;support tools;Symptoms;Syndrome;Techniques;text searching;Time;tool;tumor;Universities;verification and validation;Washington

PROJECT_TITLE: Personalized risk assessment in Neurofibromatosis Type 1

STUDY_SECTION: CDMA

STUDY_SECTION_NAME: Clinical Data Management and Analysis Study Section[CDMA]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cerebrovascular;Childhood Injury;Clinical Research;Hematology;Neurosciences;Pediatric;Rare Diseases;Sickle Cell Disease

ORG_NAME: HUGO W. MOSER RES INST KENNEDY KRIEGER

PHR: PROJECT NARRATIVE__________________________________________ The proposed research will investigate the hypothesis that silent cerebral infarctions in young children with sickle cell disease can be predicted by a combination of neuroimaging measures and neurocognitive test scores. This data will be used to determine which measures have the most utility and accuracy in this understudied population. The knowledge gained from this research could lead to development of a predictive risk score to identify young children with sickle cell disease at highest risk for silent cerebral infarctions and other neurological complications.

PI_NAMEs: LANCE, EBONI I (contact)

PROGRAM_OFFICER_NAME: PHILP, DEBORAH

PROJECT_TERMS: 3 year old;4 year old;5 year old;6 year old;Acute;Adult;Age;Anesthesia procedures;Axon;Behavioral;Blood;Brain Injuries;brain magnetic resonance imaging;brain tissue;Case/Control Studies;Cephalic;Cerebral Infarction;Cerebrovascular Circulation;Cerebrum;Characteristics;Child;Chronic Disease;Clinical;Clinical Data;Cognition;Cognitive;Cohort Studies;Collection;Data;Data Collection;Development;Diagnosis;Diagnostic;disability;Disease;Early identification;Early treatment;Education;Educational accommodation;Enzyme-Linked Immunosorbent Assay;Evaluation;executive function;experience;Fetal Hemoglobin;Future;Goals;Guidelines;Hematological Disease;Hemoglobin concentration result;high risk;hydroxyurea;Impaired cognition;improved;Inflammatory;Inherited;Injury;Intelligence;Ischemic Stroke;Knowledge;Language;Lesion;Literature;Longitudinal Studies;Magnetic Resonance Imaging;male;Mathematics;Measures;Medical;Medical History;Metabolic;Metabolic stress;Metabolism;minimal risk;Morbidity - disease rate;multidisciplinary;multimodality;Neurocognitive;neurocognitive test;Neurodevelopmental Deficit;neuroimaging;Neurologic;Neurologic Examination;Neurologic Symptoms;Neurons;neuroprotection;Neuropsychological Tests;Outcome;Oxygen;Participant;Patients;Performance;Physical Function;Physicians;Pilot Projects;Plasma;Plasma Proteins;Population;predictive marker;prevent;prospective;Proteins;Psychologist;Reading;Recommendation;Recording of previous events;Recurrence;Research;Research Personnel;Risk;Risk Factors;risk prediction;Sample Size;Sampling;School-Age Population;screening;Sedation procedure;Sensitivity and Specificity;Services;sex;Sickle Cell Anemia;Site;skills;standard of care;Stroke;Test Result;Testing;Therapeutic Intervention;Time;Training;verbal;Vulnerable Populations;White Blood Cell Count procedure;Work

PROJECT_TITLE: Neuroimaging and Neurocognitive Markers of Brain Injury in Young Children with Sickle Cell Disease

STUDY_SECTION: HCMF

STUDY_SECTION_NAME: Human Complex Mental Function Study Section[HCMF]


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Clinical Research;Genetic Testing;Genetics;Intellectual and Developmental Disabilities (IDD);Mucopolysaccharidoses (MPS);Neurosciences;Prevention;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PHR: PROJECT NARRATIVE Diagnostic DNA testing is often inconclusive, as we cannot always determine whether a given DNA change in will cause disease. We will use cells to develop a method to determine whether specific DNA changes cause a genetic condition called Hunter syndrome or are benign DNA changes. The results can help better predict whether someone will have Hunter syndrome from DNA testing.

PI_NAMEs: BUCHSER, WILLIAM J;DICKSON, PATRICIA I (contact)

PROGRAM_OFFICER_NAME: MORRIS, JILL A

PROJECT_TERMS: A549;Affect;Attenuated;Benign;Biochemical;Biological Assay;Birth;Cell Line;cell type;Cells;Cellular Morphology;Chimeric Proteins;Classification;Clinical;Complementary DNA;Consent;Data;Dermatan Sulfate;Diagnosis;Diagnostic;diagnostic accuracy;Diagnostic tests;Discrimination;Disease;disorder risk;DNA;Enzymes;experimental study;Generations;Genes;Genetic Diseases;genetic testing;genetic variant;Genetic Variation;Genome engineering;Genomics;Glycosaminoglycans;Goals;Heparitin Sulfate;Human;iduronate-2-sulfatase;Image;Impairment;improved;In Vitro;Individual;induced pluripotent stem cell;Inherited;Intellectual functioning disability;Knock-out;Laboratories;Libraries;Link;Lysosomes;Machine Learning;Measurement;Measures;Medical;Medical Records;Membrane;Methods;Molecular;molecular diagnostics;Morphology;Mucopolysaccharidoses;Mucopolysaccharidosis II;Neonatal Screening;Neurons;novel;Pathogenicity;patient derived induced pluripotent stem cells;Patients;Phenotype;phenotypic data;polysulfated glycosaminoglycan;Population;prevent;Reporting;Research;Resolution;risk prediction;Sampling;Severities;single cell sequencing;skin biopsy;stem cells;System;Technology;Test Result;Testing;Transmembrane Domain;Universities;Variant;variant of unknown significance;Washington;Whole Blood

PROJECT_TITLE: Cellular Phenotypes of Genetic Variants in Mucopolysaccharidosis

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: HIV/AIDS;Infectious Diseases

ORG_CITY: NASHVILLE

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: MEHARRY MEDICAL COLLEGE

ORG_STATE: TN

PHR: Project Narrative Understanding the biology of HIV-1 underpins the development of high priority prevention and treatment strategies. Information gained from this study of a special host protein necessary for innate immunity evasion strategies by HIV-1 will advance current knowledge on the virus-host interactions in HIV-1 pathogenesis. This study will provide a basis for developing new therapeutic interventions.

PI_NAMEs: DONG, XINHONG  (contact)

PROGRAM_OFFICER_NAME: LAWRENCE, DIANE M

PROJECT_TERMS: antagonist;Biochemical;Biological Assay;Biology;Biophysics;Calorimetry;CD4 Positive T Lymphocytes;Cell Communication;Cell membrane;Cell surface;Cells;Confocal Microscopy;Coupled;Data;Development;Down-Regulation;Endocytosis;Exhibits;experimental study;filamin;Flow Cytometry;Fluorescence Microscopy;Fractionation;Genetic;Goals;HIV;HIV-1;HIV/AIDS;Human;Image Cytometry;insight;Knowledge;Laboratories;live cell imaging;Location;Macrophage;Mediating;Membrane;Modification;Natural Immunity;novel therapeutic intervention;particle;Pathogenesis;Pathway interactions;Patients;Play;Prevention strategy;Proteins;Recycling;Reporting;Research;Role;Site;Site-Directed Mutagenesis;Specificity;Surface;T-Lymphocyte;Testing;time use;Titrations;trafficking;transmission process;treatment strategy;United States National Institutes of Health;Viral Physiology;viral transmission;Virus;virus host interaction;Virus Replication;vpu Protein

PROJECT_TITLE: HIV interactions with host cell proteins in particle release

STUDY_SECTION: HVCD

STUDY_SECTION_NAME: HIV Molecular Virology, Cell Biology, and Drug Development Study Section[HVCD]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Machine Learning and Artificial Intelligence;Orphan Drug;Precision Medicine;Radiation Oncology;Rare Diseases;Sexually Transmitted Infections;Social Determinants of Health

ORG_CITY: STANFORD

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative The incidence of HPV-related oropharyngeal cancer has been rapidly increasing in the US. In this project, we propose to develop and validate quantitative imaging biomarkers to predict risks of locoregional relapse and distant metastasis in oropharyngeal cancer. This has the potential to optimize selection of patients who are eligible for treatment de-escalation in HPV-positive disease, paving the way for precision medicine in oropharyngeal cancer.

PI_NAMEs: LE, QUYNH-THU XUAN;LI, RUIJIANG  (contact)

PROGRAM_OFFICER_NAME: OKI, NOFFISAT

PROJECT_TERMS: Address;Anatomy;Architecture;Attention;Biological;Biological Factors;chemoradiation;Clinical;Clinical Data;clinical prognostic;Clinical Trials;cohort;Complement;Data;Data Set;deep learning;deep learning model;design;Detection;Diagnosis;Disease;Disease Progression;disorder risk;Dissection;Distant;Distant Metastasis;draining lymph node;Eligibility Determination;Epidemic;Evaluation;Exhibits;Future;Gene Expression;Goals;Habitats;Heterogeneity;Histologic;Histology;HPV negative;HPV oropharyngeal cancer;HPV positive;Human papilloma virus infection;Human Papillomavirus;Image;Image Analysis;imaging biomarker;improved;improved outcome;Incidence;Individual;innovation;Institution;Invaded;Knowledge;Lymph Node Involvement;Malignant Neoplasms;malignant oropharynx neoplasm;Modality;Modeling;Molecular;Morphology;multimodal data;multitask;neglect;Neoplasm Metastasis;novel;Oncology;oral HPV infection;oral lesion;Outcome;overtreatment;participant enrollment;Pathology;Pathway interactions;Patient Selection;Patients;Pattern;Performance;Performance Status;personalized medicine;personalized predictions;Phenotype;precision medicine;preservation;Primary Neoplasm;Prognosis;prognostic;prognostic assays;Prognostic Factor;prognostic model;prognostic signature;prognostic value;prospective;prospective test;Quality of life;quantitative imaging;Radiation Therapy Oncology Group;Radiogenomics;radiological imaging;radiomics;randomized trial;randomized, clinical trials;Reduce health disparities;Regional Disease;Relapse;Resource-limited setting;response;Risk;risk prediction;risk stratification;Smoking History;standard care;Stream;success;Testing;Texture;Therapeutic;therapy outcome;therapy resistant;Tissues;Toxic effect;Training;treatment response;treatment strategy;trial enrollment;tumor;tumor heterogeneity;Underserved Population;Validation;Variant;virtual;X-Ray Computed Tomography

PROJECT_TITLE: Precision imaging for risk stratification and personalized therapy of oropharyngeal cancer

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Infectious Diseases;Orphan Drug;Rare Diseases

ORG_CITY: NEW HAVEN

ORG_NAME: CURATIX, LLC

PHR: NARRATIVE Fungal infections are responsible for more than 1.5 million deaths worldwide each year, and within the United States, invasive fungal infections (IFIs) are a significant threat to immunocompromised patients. Only a few classes of antifungal drugs are available, and the emergence of resistance within all classes is an alarming threat to global public health. Curatix is developing a new class of antifungals that act via a novel target to provide a more effective treatment strategy for IFIs in addition to enhancing the activity of current anti-fungals to overcome resistant infections.

PI_NAMEs: CHOI, JAE-YEON  (contact)

PROGRAM_OFFICER_NAME: LIU, BAOYING

PROJECT_TERMS: Address;Amphotericin B;Anabolism;analog;Animal Model;anti-fungal agents;Aspergillosis;Aspergillus;Aspergillus fumigatus;Azoles;Binding;Biochemical;Biological;Candida;Candida albicans;Candida glabrata;Candidiasis;Catalytic Domain;Cell Survival;Cessation of life;Chemicals;Clinical;Coenzyme A;cofactor;Complex;Cryptococcus;cytotoxicity;Data;Death Rate;Development;Disseminated candidiasis;Dose;Drug Kinetics;Drug resistance;Economic Burden;Economics;effective therapy;efficacy evaluation;Enzymes;Ergosterol;experience;Fluconazole;fungus;Generations;Genetic study;Goals;healthcare burden;high throughput screening;Hospitals;Human;Human Cell Line;Immunocompromised Host;improved;In Vitro;in vitro activity;in vivo;indexing;Infection;inhibitor;kinase inhibitor;Lead;lead candidate;Length of Stay;Libraries;Manuscripts;Maps;Metabolic;Metabolic Pathway;meter;Modeling;monomer;Morbidity - disease rate;mouse model;Multi-Drug Resistance;Mus;Mycoses;Nosocomial Infections;novel;novel drug class;Oral;Organism;Pantothenate kinase;Pantothenic Acid;pathogen;pathogenic fungus;Pathway interactions;Patient-Focused Outcomes;Patients;Permeability;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacologic;Pharmacology Study;Phase;Phosphorylation;Pneumocystis;Polyenes;programs;Property;Public Health;Regimen;Relationship-Building;research and development;Resistance;resistant strain;Saccharomyces cerevisiae;Safety;scaffold;screening;Solubility;Structure;Structure-Activity Relationship;therapeutically effective;treatment strategy;United States;Vitamins

PROJECT_TITLE: Antifungals targeting pantothenate phosphorylation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DCAI-F(12)]


ADMINISTERING_IC: MD

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

ORG_CITY: HOUSTON

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE The Overall Goal of the MIEHR Research Center is to elucidate the contributions of exposures in the biological, physical, social and built environments of the environmental riskscape to environmental health disparities in pregnant women and their infants. The MIEHR Center has two synergistic Research Projects that build on a unique ongoing, perinatal database and biospecimen repository: the BCM PeriBank, a Community Engagement and Dissemination Core (CEDC) and an Investigator Development Core (IDC). The MIEHR Center will accomplish its goals in research, career development and community engagement with multidisciplinary and diverse teams of community and academic experts, interdisciplinary collaborations between synergistic research projects, activities that develop a diverse workforce and community engagement that fosters equitable community stakeholder interactions.

PI_NAMEs: SYMANSKI, ELAINE  (contact)

PROGRAM_OFFICER_NAME: LINARES, DEBORAH ELIZABETH

PROJECT_TERMS: Affect;African American Women;American;Area;Aromatic Polycyclic Hydrocarbons;Awareness;Biological;Biological Specimen Banks;built environment;career development;Chemicals;Child;Cities;college;Communities;community building;community empowerment;community engagement;Complex;Data;Databases;deprivation;Development;Disasters;Disparity;Diverse Workforce;environmental disparity;Environmental Epidemiology;Environmental Exposure;Environmental Health;environmental health disparity;Environmental Impact;environmental justice;Epidemiology;Equity;Ethnic Population;Exposure disparity;Fetal health;Fire - disasters;Fostering;Future;Goals;Hazardous Waste Sites;Health;Health Disparities Research;health disparity;health disparity populations;health literacy;Historically Black Colleges and Universities;Hurricane;Hypertension;Individual;Industrialization;Infant;Infant Health;infant morbidity;innovation;Institution;interdisciplinary collaboration;Knowledge;Leadership;Life;Life Cycle Stages;low socioeconomic status;Maternal Health;maternal morbidity;Medicine;Metals;Mothers;multi-ethnic;multi-racial;multidisciplinary;Natural Disasters;Neighborhoods;next generation;Not Hispanic or Latino;obstetric outcomes;Outcome;Perinatal;Physical environment;Pollution;Population;Positioning Attribute;Pregnancy;pregnancy disorder;Pregnant Women;Premature Birth;Race;racial difference;racial disparity;racial population;Research;Research Activity;Research Personnel;Research Project Grants;resilience;Resources;response;Risk;Role;Sampling;Second Pregnancy Trimester;Social Environment;stressor;System;Talents;Testing;Texas;Third Pregnancy Trimester;Universities;White Women;Woman

PROJECT_TITLE: Maternal and Infant Environmental Health Riskscape (MIEHR) Research Center


NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Social Determinants of Health

PROJECT_TERMS: Administrator;Advisory Committees;Affect;African American population;Annual Reports;Area;Biological;built environment;career development;catalyst;cohesion;college;Communication;Communities;community advisory board;community building;community engagement;Databases;design;Development;digital;Diverse Workforce;Effectiveness;Ensure;Environmental Health;environmental health disparity;Equity;Evaluation;experience;Fostering;Future;Geography;Goals;Health;Health Disparities Research;health disparity populations;Historically Black Colleges and Universities;Human Subject Research;improved;Infant;Infant Health;Infrastructure;Leadership;Maternal Health;Medicine;meetings;Mentors;multidisciplinary;National Institute of Environmental Health Sciences;National Institute on Minority Health and Health Disparities;Outcome;Physical environment;Pilot Projects;Play;Policies;Policy Maker;Positioning Attribute;Pregnant Women;programs;Regulation;Reporting;Research;Research Personnel;Research Project Grants;resilience;Resources;Social Environment;Structure;symposium;synergism;Talents;Texas;Training Activity;Translating;Translations;Universities;web site;Writing

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Brain Disorders;Neurosciences

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

PHR: Project Narrative Astrocytes are critical mediators of innate immunity in the brain. Activation of innate immunity in the brain causes astrocytes to undergo astrogliosis, which contributes to the pathogenesis of neuroinflammatory and neurodegenerative diseases. The mechanisms that regulate astrogliosis are incompletely understood. Preliminary studies from our lab support a role for PARP7, an enzyme that catalyzes the post-translational modification known as mono-ADP-ribosylation (MARylation), in astrogliosis. Using unique chemical tools, we are investigating the mechanism by which PARP7-mediated MARylation regulates astrogliosis. The knowledge gained from these studies could lead to novel treatments for neuroinflammatory (e.g. multiple sclerosis) and neurodegenerative diseases (e.g. Alzheimer's disease), which are major health burdens.

PI_NAMEs: COHEN, MICHAEL S (contact)

PROGRAM_OFFICER_NAME: TYLER, WILLIAM A

PROJECT_TERMS: acute infection;Address;Adenosine Diphosphate Ribose;ADP ribosylation;Alzheimer's Disease;Amino Acids;analog;Area;Astrocytes;astrogliosis;Bacteria;Binding;Biology;Brain;Brain Injuries;Cell Membrane Permeability;Cell Physiology;cell type;Cells;Cellular biology;Central Nervous System;chemical synthesis;Chemicals;Chemistry;chronic inflammatory disease;Collaborations;Data;design;Development;Endowment;Engineering;Environment;Enzymes;Family;Family member;Funding;Generations;Goals;Growth Factor;Health;high risk;Immune response;Immune signaling;Immunooncology;immunoregulation;improved;Individual;inhibitor;Innate Immune Response;insight;Ischemic Stroke;knockout gene;Knowledge;Laboratories;Lead;Ligands;Literature;Mammalian Cell;Mammals;Mass Spectrum Analysis;Mediating;Mediator;member;Membrane;multidisciplinary;Multiple Sclerosis;Natural Immunity;Nature;Nerve Degeneration;Nervous System Trauma;Neurodegenerative Disorders;neuroinflammation;Neurosciences;Nicotinamide adenine dinucleotide;novel;novel therapeutic intervention;Nucleotides;pathogen;Pathogenesis;Pathology;Pathway interactions;Phenotype;Physiological;Poly(ADP-ribose) Polymerase Inhibitor;Post-Translational Protein Processing;Process;Protein Engineering;Proteins;response;Role;Shapes;Signal Transduction;Site;spatiotemporal;steroid hormone;Stimulus;Structure;tandem mass spectrometry;Testing;tool;Toxin;Variant;Virus;Work

PROJECT_TITLE: Decoding protein MARylation networks in astrocytes using chemical biology approaches

STUDY_SECTION: SBCA

STUDY_SECTION_NAME: Synthetic and Biological Chemistry A Study Section[SBCA]


NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

PI_NAMEs: SALIHU, HAMISU  (contact)

PROJECT_TERMS: Achievement;Address;Affect;African American;African American population;African American Women;Applications Grants;Award;base;Basic Science;Biological Sciences;career;career development;Child;Climate;Clinical;college;Communities;Coupled;Data;Death Rate;design;Development;Disadvantaged;Disasters;Discipline;Disparity;Doctor's Degree;Education;Environmental Health;environmental health disparity;Ethnic Population;Extramural Activities;Faculty;Fostering;Funding;Funding Mechanisms;Goals;Health Disparities Research;health disparity;health disparity populations;Health Professional;Health Promotion;health related quality of life;high risk;Historically Black Colleges and Universities;improve minority health;Individual;Infant;Infant Mortality;Institution;interest;Lead;Longevity;Maternal and Child Health;Maternal Mortality;Measures;Medicine;Mentors;Minority;Minority Groups;minority investigator;Mission;multidisciplinary;National Institute on Minority Health and Health Disparities;next generation;outreach;Pathway interactions;Pilot Projects;Population;population health;Postdoctoral Fellow;Pregnant Women;premature;Principal Investigator;Probability;Program Development;programs;Public Health;Quality of life;racial disparity;racial population;recruit;Reduce health disparities;Research;Research Personnel;Research Project Grants;Research Support;resilience;Secure;skills;success;Talents;Texas;Time;Training;training opportunity;Translational Research;Trust;Underrepresented Minority;United States National Institutes of Health;Universities

PROJECT_TITLE: Investigator Development Core


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences;Pediatric

ORG_CITY: ANN ARBOR

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative Convergent research finds a single overarching general factor, the “P factor”, contributes to a broad array of psychiatric symptoms, but we know very little about what factors influence the neurodevelopment of the P factor during youth. This project addresses this gap in knowledge by leveraging data from the seminal Adolescent Brain Cognitive Development (ABCD) study. Using advanced multivariate neuroimaging methods, we systematically map how social/environmental, psychological, and genetic factors shape brain structure and function during adolescence which in turn leads to the emergence of the P factor.

PI_NAMEs: SRIPADA, CHANDRA SEKHAR (contact)

PROGRAM_OFFICER_NAME: THOMAS, LAURA ANDERSON

PROJECT_TITLE: Building a multi-factor etiological model of the emergence of general psychopathology (the "P factor") in adolescence with multi-modal neuroimaging in ABCD

STUDY_SECTION: BGES

STUDY_SECTION_NAME: Behavioral Genetics and Epidemiology Study Section[BGES]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

PI_NAMEs: BULLARD, ROBERT D (contact)

PROJECT_TERMS: Achievement;Address;Advocacy;Affect;African American;African American population;African American Women;Area;Aromatic Polycyclic Hydrocarbons;Awareness;Biological;built environment;Chemicals;Child;Cities;Communication;Communities;community advisory board;community building;community engaged research;community engagement;community partners;community partnership;Complement;Country;Development;Disasters;Dissemination and Implementation;effectiveness evaluation;Environment;environmental disparity;Environmental Exposure;Environmental Health;environmental health disparity;environmental justice;Evaluation;evidence base;Evidence based intervention;Exposure to;Fathers;Focus Groups;Fostering;Goals;Health;Health Disparities Research;health disparity;health literacy;Health Policy;Health Priorities;Historically Black Colleges and Universities;Individual;Infant;Infant Health;Infant Mortality;infant outcome;Jordan;Lead;Leadership;Learning;lens;literacy;Maternal Health;maternal outcome;mathematical ability;Metal exposure;Methods;minority health;minority health disparity;Mothers;multimodality;National Institute on Minority Health and Health Disparities;neighborhood disadvantage;Neighborhoods;Physical environment;Pilot Projects;Play;Policies;Policy Maker;Pregnant Women;Premature Birth;Procedures;Process;Qualifying;Qualitative Research;racial disparity;Research;Research Activity;Research Methodology;Research Personnel;Research Project Grants;resilience;response;Risk;Risk Reduction;Role;Schools;Science;Social Environment;socioeconomic disadvantage;Strategic Planning;stressor;success;Texas;Translating;Universities;Vision;Work

PROJECT_TITLE: Community Engagement and Dissemination Core


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Climate-Related Exposures and Conditions;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

PROJECT_TERMS: Address;African American population;African American Women;American;Anthracenes;Area;Aromatic Polycyclic Hydrocarbons;Benzo(a)pyrene;biobank;Biological;Birth;black/white disparity;built environment;Case/Control Studies;chemical association;Chemical Exposure;Chemicals;Child;college;Color;Communities;Complex;Computerized Medical Record;Data;data repository;design;Development;Disasters;disorder risk;disparity reduction;economic cost;Environment;Environmental Health;environmental health disparity;Epidemiology;Event;experience;Exposure to;Family;Floods;Fluorine;Foundations;Future;Genetic;Goals;Hazardous Waste Sites;Health;health disparity;health disparity populations;Healthcare;Hurricane;improved;Individual;Industry;Infant;Infant Health;low socioeconomic status;Maternal and Child Health;Maternal Exposure;Maternal Health;Medicine;Metal exposure;Metals;Morbidity - disease rate;mortality;Mothers;Natural Disasters;Neighborhoods;Not Hispanic or Latino;obstetric outcomes;Outcome;Perinatal;Personal Satisfaction;Physical environment;Placenta;Play;pollutant;Population;Population Heterogeneity;Poverty;Predisposition;Pregnancy;Pregnant Women;Premature Birth;preventive intervention;Questionnaires;Race;racial disparity;Research;Research Project Grants;response;Rest;Risk;Role;Sampling;Social Environment;societal costs;Source;Statistical Methods;stressor;successful intervention;superfund site;Term Birth;Texas;White Women;Woman;Work

PROJECT_TITLE: Project 1: The Environmental Riskscape, Disasters and Obstetric Outcomes


NIH_SPENDING_CATS: Biotechnology;Cancer;Childhood Leukemia;Clinical Research;Gene Therapy;Genetics;Hematology;Immunotherapy;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_DEPT: PEDIATRICS

PHR: Project Narrative Current treatment regimens are not adequate for patients with relapsed T-cell acute lymphoblastic leukemia (T- ALL). We propose a novel approach to target T-ALL by using innate-like cytotoxic gamma delta (γδ) T cells and will test two strategies, one utilizing cellular stress modulation as a means to sensitize T-ALL to γδ T cell- mediated killing, and the other through the use of a CD5-directed chimeric antigen receptor (CAR). Research outlined in this proposal will provide invaluable preclinical data necessary to develop γδ T cell-based strategies to treat T-ALL.

PI_NAMEs: RAIKAR, SUNIL SUDHIR (contact)

PROGRAM_OFFICER_NAME: BOULANGER-ESPEUT, CORINNE A

PROJECT_TERMS: Acute T Cell Leukemia;acute T-cell lymphoblastic leukemia cell;adeno-associated viral vector;Aftercare;Allogenic;Animal Cancer Model;Antigen Presentation;Antigen Targeting;biological adaptation to stress;Biology;bisphosphonate;Bone Marrow Transplantation;Bortezomib;cancer cell;Cancerous;CAR T cell therapy;career;CD28 gene;CD95 Antigens;cell killing;Cell Line;Cell surface;Cell Therapy;Cell-Mediated Cytolysis;Cells;Cellular Stress;Cessation of life;chemotherapeutic agent;chemotherapy;Childhood Hematopoietic Neoplasm;chimeric antigen receptor;chimeric antigen receptor T cells;Clinical;cytokine;cytotoxic;cytotoxicity;Data;design;Disease;Disease remission;Down-Regulation;Effectiveness;epigenetic drug;Epigenetic Process;experience;experimental study;gene therapy;genetically modified cells;Goals;graft vs host disease;Hematopoietic Stem Cell Transplantation;Immunocompromised Host;Immunology;Immunosuppression;Immunotherapeutic agent;Immunotherapy;In Vitro;in vivo;ineffective therapies;innovation;interest;Laboratories;lentivirally transduced;Lentivirus Vector;leukemia;Life;life span;Ligands;Major Histocompatibility Complex;Malignant - descriptor;Malignant Neoplasms;Mediating;Mentorship;Methods;minimal risk;Modification;Molecular;Mus;Nature;Nelarabine;Non-Malignant;novel;novel strategies;overexpression;Pathway interactions;Patients;Pediatric Oncologist;peripheral blood;Physicians;pre-clinical;preclinical study;Predisposition;Process;Proteasome Inhibition;Proteasome Inhibitor;receptor;receptor expression;Recurrent disease;Relapse;Remission Induction;Research;Sampling;Scientist;Series;Serum;side effect;Stress;Surface;T cell therapy;T-Lymphocyte;T-Lymphocyte Subsets;Testing;therapy development;TNFRSF10A gene;TNFSF10 gene;tool;Training;transgene expression;translational immunology;Transplantation;Treatment Protocols;tumor;Viral;Viral Vector;Work;Xenograft procedure;γδ T cells

PROJECT_TITLE: Gamma delta T-cell immunotherapy for T-cell acute lymphoblastic leukemia

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cardiovascular;Clinical Research;Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hypertension;Infant Mortality;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

PROJECT_TERMS: Affect;African American Women;American;Area;Aromatic Polycyclic Hydrocarbons;Awareness;Behavior;Biological;Biological Factors;Blood;built environment;Cells;Characteristics;Chemicals;Cities;Clinical;college;Complex;County;Data;Development;Disasters;Disparity;Disparity population;disparity reduction;Eclampsia;economic cost;Economics;Enrollment;Environmental Health;environmental health disparity;Ethnic Population;Evaluation;Exposure to;Family;Goals;Hazardous Waste Sites;Health;health care quality;health disparity;health disparity populations;Home;Hypertension;improved;Individual;Industrialization;Infant;Infant Health;interest;Intervention;Maternal and Child Health;Maternal Health;maternal risk;Medicine;Metadata;Metals;microbiome;Minority;model development;Morbidity - disease rate;mortality risk;multi-ethnic;multi-racial;Neighborhoods;neonatal morbidity;Neonatal Mortality;Not Hispanic or Latino;obstetric outcomes;Outcome;Pediatric Hospitals;Personal Satisfaction;Physical environment;Populations at Risk;Postpartum Period;Poverty;Pre-Eclampsia;Pregnancy;pregnancy disorder;pregnancy hypertension;Pregnant Women;Premature Birth;Prevalence;prospective;psychosocial stressors;racial determinant;racial disparity;racial population;Reproductive History;Research;Research Project Grants;Resources;Rest;Risk;Risk Factors;risk prediction;RNA;Second Pregnancy Trimester;Social Environment;sociodemographics;socioeconomic disadvantage;Specific qualifier value;stressor;Testing;Texas;Third Pregnancy Trimester;Time;Validation;Vulnerable Populations;White Women;Woman;Women's Health

PROJECT_TITLE: Project 2: Disparities-Aware Classifiers for Maternal and Infant Health


NIH_SPENDING_CATS: Clinical Research;Genetics;HIV/AIDS;Immunization;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE The role of HIV specific HLA-E restricted CD8 T cell responses in not known for either infection or vaccination. In this study, we will determine the biological importance of these responses in both settings. In addition, we will determine their function to understand how such responses can be used to improve HIV vaccines and therapies.

PI_NAMEs: BANSAL, ANJU ;GOEPFERT, PAUL A. (contact)

PROGRAM_OFFICER_NAME: D'SOUZA, PATRICIA D

PROJECT_TERMS: Acute;acute infection;adaptive immunity;Address;Alleles;alpha-beta T-Cell Receptor;Antibodies;Antigens;Binding;Biological;CD8-Positive T-Lymphocytes;Cells;Characteristics;Chronic;chronic infection;Data;efficacy study;Epitopes;experimental study;Frequencies;Future;Gene Expression;Gene Expression Profile;Genetic;Genetic Polymorphism;Goals;Grant;HIV;HIV Infections;HIV therapy;HIV vaccine;HIV-1;HLA G antigen;HLA-A gene;Immune;Immunologic Surveillance;improved;in vitro activity;Individual;Infection;insight;Interferon Type II;KLRD1 gene;Knowledge;Macaca;Macaca mulatta;Mediating;Methodology;Modality;Molecular;Molecular Profiling;Natural Killer Cells;novel;Outcome;pathogen;Pathogenicity;Patients;Peptide Leader Sequences;Peptides;Phenotype;Prevention;Preventive vaccine;Process;Proteins;Proteome;Publishing;Reagent;receptor;Reporting;Resources;response;Role;Sampling;single-cell RNA sequencing;SIV;T cell response;T-Cell Receptor;T-cell receptor repertoire;T-Lymphocyte;T-Lymphocyte Epitopes;Therapeutic;Time;tool;Vaccinated;Vaccination;Vaccine Design;vaccine efficacy;Vaccines;Variant;vector;Viral;Viral Physiology;Virus;Virus Diseases;Work

PROJECT_TITLE: Defining the biological relevance of HIV specific HLA-E restricted CD8 T cell responses

STUDY_SECTION: HIVD

STUDY_SECTION_NAME: HIV Immunopathogenesis and Vaccine Development Study Section[HIVD]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Chronic Pain;Neurosciences;Pain Research;Pediatric;Substance Misuse;Underage Drinking

ORG_CITY: NEW ORLEANS

ORG_DEPT: PHYSIOLOGY

ORG_NAME: LSU HEALTH SCIENCES CENTER

ORG_STATE: LA

PHR: Adolescent alcohol exposure leads to long term detrimental effects on behavior, with recent evidence indicating exposure causes increased responsiveness to pain or hyperalgesia in adulthood, however the neural and biochemical alterations leading to this phenotype are not known. Here, we propose a fellowship training plan where a physician-scientist in training will investigate adolescent alcohol effects on amygdalar neuropeptide and glutamate systems, and will test the role of those systems in mediating adolescent alcohol induced hyperalgesia in adulthood. The findings from the proposed work will (1) characterize how the amygdala changes during and after adolescent alcohol exposure, (2) test and inform the development of translationally relevant therapies, and (3) foster the development of a promising M.D./Ph.D. student with training in alcohol and pain related neuroscience.

PI_NAMEs: SHARFMAN, NATHAN  (contact)

PROGRAM_OFFICER_NAME: EGLI, MARK

PROJECT_TERMS: Acids;Acute;Address;Adolescence;Adolescent;adolescent alcohol effect;adolescent alcohol exposure;Adult;Age;Air;alcohol behavior;alcohol effect;alcohol exposure;alcohol use disorder;Alcohols;Amygdaloid structure;antagonist;Bathing;Behavior;Biochemical;Brain;Brain region;Cell Nucleus;Cells;Chronic;chronic alcohol ingestion;chronic pain;chronic painful condition;cohort;comorbidity;Development;Doctor of Medicine;doctoral student;Drug Receptors;Electrophysiology (science);Ethanol;Exposure to;Fellowship;Female;Fostering;Functional disorder;Functional Magnetic Resonance Imaging;Glutamate Receptor;glutamatergic signaling;Glutamates;Human;Hyperalgesia;Infusion procedures;male;mature animal;Measures;mechanical allodynia;Mediating;Melanocortin 4 Receptor;Modeling;N-Methyl-D-Aspartate Receptors;N-Methylaspartate;neural;neuronal excitability;Neurons;Neuropeptides;Neurosciences;Nociception;Pain;Pain Disorder;pain model;pain processing;patch clamp;Phenotype;Physicians;postnatal;postsynaptic;Postsynaptic Membrane;Prevalence;protein expression;Rattus;receptor;Receptor Activation;receptor expression;receptor function;Receptor Signaling;Receptor Up-Regulation;receptor upregulation;Recording of previous events;Reporting;Rodent Model;Role;Scientist;Signal Transduction;Slice;Structure;System;Testing;trafficking;Training;transmission process;underage drinker;underage drinking;vapor;voltage clamp;Western Blotting;Wistar Rats;Withdrawal;Work;α-Melanocyte stimulating hormone

PROJECT_TITLE: Amygdala Modulation of Adolescent Alcohol Effects on Pain