NIH_SPENDING_CATS: Clinical Research;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Liver Disease;Organ Transplantation;Social Determinants of Health;Transplantation

ORG_CITY: BIRMINGHAM

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Narrative The current system of liver transplant allocation assigns candidates a score based on laboratory testing (known as the Model for End Stage Liver Disease, or MELD) that is meant to estimate the risk of dying while awaiting transplant, and patients who are thought to have a higher risk of mortality than reflected in their calculated MELD score are assigned a higher exception or allocation MELD score that is meant to better reflect risk. A critical flaw in this policy is that it does not account for regional variation in social determinants of health and access to care which likely have significant effects on waitlist mortality; rather, the risk associated with a given MELD score is assumed to be the same everywhere in the nation. Understanding and accounting for the role of geographic location in the risk of waitlist mortality has the potential to ameliorate this flaw and inform a more equitable liver transplant allocation system.

PI_NAMEs: CANNON, ROBERT M. (contact)

PROGRAM_OFFICER_NAME: LOH, KATRINA SHUEH WEN

PROJECT_TERMS: Accounting;Address;advanced simulation;analytical method;Area;Award;career;Communities;Country;County;Cox Proportional Hazards Models;Data;Diagnosis;differences in access;Disparity;disparity reduction;Distant;end stage liver disease;Equity;Face;Fostering;Funding;geographic difference;geographic disparity;Geographic Locations;Geography;Goals;Growth;Health;health care availability;Health Service Area;high risk;Knowledge;Laboratories;Literature;Liver;liver transplantation;Location;Mentors;Methods;Modeling;mortality;mortality risk;novel;Outcome;Paint;Patients;personalized approach;Play;Policies;Population;Predictive Factor;Prevalence;Regional Disease;Regression Analysis;Research;Research Personnel;Rest;Risk;Risk Estimate;Role;role model;Running;Rural Appalachia;Scientist;Side;simulation;social health determinants;Standardization;Surgeon;System;Techniques;Testing;Training;Transplantation;Variant;Waiting Lists

PROJECT_TITLE: Geographic Variation in Non-HCC MELD Exceptions and Its Effect on Liver Transplant Waitlist Outcomes

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


ADMINISTERING_IC: GM

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics;Neurosciences

ORG_CITY: ROCHESTER

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF ROCHESTER

ORG_STATE: NY

PHR: PROJECT NARRATIVE The following project will decipher the functions of a key tRNA modification enzyme required for proper neurodevelopment in humans. These discoveries will provide a foundation for understanding the molecular roles of a widespread tRNA modification linked to brain development.

PI_NAMEs: FU, DRAGONY  (contact)

PROGRAM_OFFICER_NAME: VATAKIS, DIMITRIOS NIKOLAOS

PROJECT_TERMS: Affect;Age;Aminoacylation;Area;Biogenesis;Biological;Brain;brain abnormalities;Cell Count;cell type;Cells;Charge;Chemical Structure;Codon Nucleotides;Cognitive deficits;Complement;Defect;density;Development;Developmental Delay Disorders;Disease;Ensure;Enzymes;Eukaryota;Exhibits;forging;Foundations;Genes;Genetic study;Goals;Growth;Growth and Development function;Guanosine;Health;Human;human disease;Impaired cognition;Impairment;Individual;insight;Intellectual functioning disability;Knockout Mice;Knowledge;Link;loss of function;Mammalian Cell;Measures;Modeling;Modification;Molecular;Mouse Strains;Mus;Mutation;neurodevelopment;Neurodevelopmental Disorder;Neurons;novel;Nucleotides;Pathogenicity;Pathology;Pathway interactions;Play;Process;Proliferating;Protein Biosynthesis;protein folding;Proteins;proteostasis;Research;ribosome profiling;Ribosomes;RNA;RNA Splicing;Role;spatiotemporal;System;Technology;Testing;Tissues;Transfer RNA;Transfer RNA Aminoacylation;translational impact;Translations;tRNA Methyltransferases;Tyrosine-Specific tRNA;Up-Regulation;Variant

PROJECT_TITLE: Molecular functions of the TRMT1 tRNA modification enzyme

STUDY_SECTION: MGA

STUDY_SECTION_NAME: Molecular Genetics A Study Section[MGA]


NIH_SPENDING_CATS: Biotechnology

ORG_CITY: UNIVERSITY PARK

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

ORG_STATE: PA

PHR: Project Narrative The proposed research is directed towards understanding the mechanisms of purinosome formation in human cells. This work represents a pioneering effort to demonstrate how metabolic pathways organize through metabolons within a cell for increased metabolic flux as well as spatial regulation.

PI_NAMEs: BENKOVIC, STEPHEN J (contact)

PROGRAM_OFFICER_NAME: BARSKI, OLEG

PROJECT_TERMS: 3-Dimensional;Animal Model;Biochemical;Biological Assay;Biophysics;Cell Culture Techniques;cell growth;Cell Line;Cell Proliferation;Cell Survival;Cells;cellular imaging;Characteristics;Chemicals;cofactor;crosslink;Diagnostic;Diffuse;Dihydrofolate Reductase;Diphosphates;DNA;Environment;enzyme pathway;Enzymes;Evaluation;fluorescence imaging;Gases;Genetic;Growth;Heat-Shock Proteins 70;Heat-Shock Proteins 90;Hot Spot;Human;Human Cell Line;Hydroxymethyltransferases;imaging capabilities;imaging modality;In Situ;in vivo;insight;Invaded;ionization;Ions;Isotope Labeling;Label;Mass Spectrum Analysis;Metabolic;Metabolic Pathway;Metabolism;Microtubules;Mitochondria;mitochondrial membrane;Molecular Chaperones;Movement;Multienzyme Complexes;novel;Organelles;Pathway interactions;Pattern;pharmacologic;Phosphorylation;Positioning Attribute;Post-Translational Protein Processing;Proteins;Purine Nucleotides;Purines;Regulation;Research;Resort;RNA;Role;Series;Signal Pathway;Signal Transduction;stoichiometry;Structure;Surface;Surveys;Techniques;Tubular formation;tumor progression;Visualization;Work;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Transformylase Enzymes Dihydrofolate Reductase

STUDY_SECTION: MSFA

STUDY_SECTION_NAME: Macromolecular Structure and Function A Study Section[MSFA]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Emerging Infectious Diseases;HIV/AIDS;Immunization;Infectious Diseases;Lung;Nanotechnology;Orphan Drug;Prevention;Rare Diseases;Tuberculosis;Tuberculosis Vaccine;Vaccine Related

ORG_CITY: SEATTLE

ORG_NAME: HDT BIO CORPORATION

ORG_STATE: WA

PHR: Project Narrative We now know that effective tuberculosis vaccines can be developed with defined antigens, properly adjuvanted, and three decades of antigen discovery has made it possible to focus on a short list of vaccine candidates. We have developed a third generation RNA vaccine platform capable of inducing potent T cells in small animals and non-human primates, as well as new formulation/delivery technologies that enable a new generation of RNA adjuvants. We will test the RNA vaccine platform as well as RNA-based adjuvants, alone and in combination, to optimize protective immunity against tuberculosis, with an emphasis on mucosal immune responses.

PI_NAMEs: REED, STEVEN GREGORY (contact)

PROGRAM_OFFICER_NAME: SINGH, ANJALI

PROJECT_TERMS: adaptive immune response;Address;Adjuvant;Aerosols;Agonist;Alpha Virus;Animals;Antigens;Area;Brazil;Businesses;Cellular Immunity;Clinical;clinical development;Clinical Trials;clinically relevant;Collaborations;Combined Vaccines;Communicable Diseases;cost;cost effective;Coupled;COVID-19 vaccine;design;Development;disorder prevention;Dose;Formulation;Generations;Goals;Human;Immune response;Immunization;immunogenicity;improved;in vivo;India;Innate Immune Response;innovation;Intellectual Property;Intramuscular;Kinetics;large scale production;Lipids;Lung;manufacture;Measures;Mind;Mucosal Immune Responses;Mucosal Immunity;Mucous Membrane;Mus;Mycobacterium tuberculosis;Mycobacterium tuberculosis antigens;nanoparticle;Natural Products;nonhuman primate;novel;Pathway interactions;Phase;Phase I Clinical Trials;Phase II Clinical Trials;prevent;Process;Production;Protein Subunits;Proteins;Recombinant Proteins;Regimen;Replicon;response;Risk;RNA;RNA replication;RNA vaccination;RNA vaccine;Route;Safety;Signal Transduction;Subunit Vaccines;success;System;T-Lymphocyte;Technology;Testing;TLR3 gene;TLR4 gene;Tuberculosis;tuberculosis immunity;Tuberculosis Vaccines;vaccination strategy;vaccine candidate;vaccine delivery;vaccine development;vaccine discovery;vaccine distribution;vaccine platform;Vaccines

PROJECT_TITLE: RNA Vaccine Innovations for TB: Targeting the Mucosa


NIH_SPENDING_CATS: Genetics

ORG_CITY: ATHENS

ORG_NAME: UNIVERSITY OF GEORGIA

ORG_STATE: GA

PHR: PROJECT NARRATIVE Many cell types have hundreds of important structures (organelles) that are arranged into complex patterns (for example the respiratory epithelial cells carry fields of motile cilia and the cells in the inner ear have rows of sensory stereocilia). These patterns are physiologically important but the mechanisms of their formation are largely unknown. Here we will be using the protist model that assembles unusually complex patterns, Tetrahymena, and genetic tools, to uncover and study novel genes whose products regulate the intracellular pattern formation.

PI_NAMEs: GAERTIG, JACEK  (contact)

PROGRAM_OFFICER_NAME: RIGAS, MARC

PROJECT_TERMS: airway epithelium;Alleles;analog;Animals;antagonist;Anterior;Apical;Armadillo Repeat;Biochemical;Calcium-Binding Proteins;Calmodulin-Binding Proteins;causal variant;CCNE1 gene;cell assembly;Cell division;Cell Polarity;cell type;Cells;Centrosome;Cilia;cilium motility;Complex;Cues;Cytoskeleton;Daughter;Epithelial Cells;Generations;Genes;Genetic;Genetic Models;Genetic Screening;Goals;Image;Inner Hair Cells;Interphase;Joubert syndrome;kinetosome;Labyrinth;Left;Link;Maintenance;Malaria;Maps;Modeling;Molecular;molecular domain;Morphogenesis;mutant;Mutation;Natural regeneration;novel;Oral;Organelles;Orthologous Gene;Outcome;Parasites;Pathway interactions;Pattern;Pattern Formation;Phenocopy;Phenotype;Phosphotransferases;Physiological;Plasmodium;polarized cell;Population;Positioning Attribute;Property;Proteins;Resolution;reverse genetics;Role;scaffold;Sensory;Side;Signal Transduction;Structure;Surface;synergism;Tertiary Protein Structure;Testing;Tetrahymena;Tetrahymena thermophila;tool;Trauma;Work

PROJECT_TITLE: Intracellular pattern formation

STUDY_SECTION: NCSD

STUDY_SECTION_NAME: Nuclear and Cytoplasmic Structure/Function and Dynamics Study Section[NCSD]


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Diabetes;Genetics;Human Genome;Kidney Disease

ORG_CITY: PHILADELPHIA

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative Diabetic nephropathy is the leading cause of end-stage renal disease and a major contributor to morbidity and mortality. Despite antihypertensive therapy and glycemic control, an estimated 40% of patients ultimately develop chronic kidney disease. Single cell sequencing of early diabetic kidney samples can reveal the cell types and pathways that contribute to disease progression and help to identify novel treatment targets.

PI_NAMEs: WILSON, PARKER C. (contact)

PROGRAM_OFFICER_NAME: RANKIN, TRACY L

PROJECT_TERMS: Adrenal Cortex Hormones;Adult;Advisory Committees;Albuminuria;Anti-Hypertensive Agents;ATAC-seq;Atlases;Basic Science;Binding Sites;Bioinformatics;Biological Markers;Blood Glucose;Body Weight;candidate identification;career development;Cell Nucleus;cell type;Cells;ChIP-seq;Chromatin;chromatin modification;Chronic;Chronic Kidney Failure;Clinical Services;clinical training;Communication;computer program;Crossbreeding;Data;Data Set;db/db mouse;Dexamethasone;Diabetes Mellitus;diabetic;Diabetic mouse;Diabetic Nephropathy;differential expression;Disease;Disease Progression;Dissociation;DNA;End stage renal failure;Enhancers;Enterobacteria phage P1 Cre recombinase;Epithelial Cells;Exons;experience;Foundations;Funding;Gene Expression;Genes;Genetic Transcription;genome wide association study;Glucocorticoid Receptor;Glucocorticoids;Gluconeogenesis;Glucose;glycemic control;Goals;Grant;Human;human data;human model;Hyperglycemia;Immunofluorescence Immunologic;Immunohistochemistry;Impairment;In Vitro;in vitro Model;in vivo;Individual;Inflammation;Injury;Injury to Kidney;Insulin;insulin sensitivity;K-Series Research Career Programs;Kidney;kidney cortex;Knock-out;knowledgebase;Laboratories;LoxP-flanked allele;Manuscripts;Measures;Memory;Mentors;Metabolic;Metabolism;Methods;Modeling;Molecular Biology;Molecular Conformation;molecular pathology;Morbidity - disease rate;mortality;mouse model;multimodality;multiple omics;Mus;Nature;non-diabetic;novel;Nuclear;Output;Pathway interactions;Patients;Physicians;Principal Investigator;Process;promoter;Promoter Regions;public database;Publishing;receptor binding;Recording of previous events;Regulation;Reproducibility;Research;Research Ethics;Resources;response;Response Elements;risk variant;Sampling;Scientist;Signal Transduction;single cell sequencing;single nucleus RNA-sequencing;Site;skills;Solid;Tamoxifen;Testing;Time;TNF gene;Transcript;transcription factor;transcriptome sequencing;Universities;Up-Regulation;Urine;Washington;Work;Writing;XCL1 gene

PROJECT_TITLE: The Single Cell Landscape of Early Human Diabetic Nephropathy

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Depression;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Pediatric;Serious Mental Illness

ORG_CITY: BOSTON

ORG_DEPT: PSYCHOLOGY

ORG_NAME: NORTHEASTERN UNIVERSITY

ORG_STATE: MA

PHR: PROJECT NARRATIVE In the United States, adolescents experience alarmingly high rates of major depression, and gold-standard treatments are only effective for approximately half of patients. Rumination may be a promising treatment target, as it is well-characterized at the neural level and contributes to depression onset, maintenance, and recurrence as well as predicts treatment non-response. Accordingly, the proposed research will investigate whether an innovative mindfulness-based real-time fMRI neurofeedback intervention successfully elicits change in the brain circuit underlying rumination to improve clinical outcomes among depressed adolescents.

PI_NAMEs: AUERBACH, RANDY PATRICK;WHITFIELD-GABRIELI, SUSAN  (contact)

PROGRAM_OFFICER_NAME: GARVEY, MARJORIE ANN

PROJECT_TERMS: Address;Adolescent;adolescent mental health;Adult;Affect;Aftercare;Age;Attention;Attenuated;Brain;child depression;Childhood;cingulate cortex;Clinical;clinical care;Coupled;depressive symptoms;Diagnosis;Disease;Dose;Double-Blind Method;Ecological momentary assessment;Emergency Situation;emotional distress;Environment;Exhibits;experience;Functional Magnetic Resonance Imaging;Health Benefit;health organization;improved;inattention;innovation;instrument;Intervention;Interview;Magnetic Resonance Imaging;Maintenance;Major Depressive Disorder;Medial;Mental Depression;Mental Health;mindfulness;mindfulness meditation;Mindfulness Training;Motivation;Network-based;neural;neural circuit;Neuroanatomy;neurofeedback;novel;Onset of illness;Outcome;Patient Self-Report;Patients;Pattern;perceived stress;Perception;Persons;Phase;Precision Medicine Initiative;Prediction of Response to Therapy;Prefrontal Cortex;primary outcome;Questionnaires;Randomized;randomized, clinical trials;Randomized, Controlled Trials;Recurrence;reduce symptoms;Relapse;Research;Rest;rumination;Sampling;Schizophrenia;secondary outcome;Self Efficacy;skills;standard care;suicidal risk;Surgeon;sustained attention;symptomatic improvement;Symptoms;Techniques;Testing;Therapeutic;Thinking;Time;Training;Treatment Efficacy;United States;Visual

PROJECT_TITLE: Targeting adolescent depression symptoms using network-based real-time fMRI neurofeedback and mindfulness meditation


ORG_DEPT: BIOCHEMISTRY

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: PROJECT NARRATIVE G protein-coupled receptors (GPCRs) are the largest family of cell surface receptors in the human genome, and they are also the proteins most widely targeted by clinically used drugs. GPCRs are implicated in many different biomedical areas, including neuropsychiatric disorders, cardiovascular disease, cancer, allergy, asthma, or pain management. The goal of this application is to develop new state-of-the-art assay technology to improve and accelerate the study and pharmacological targeting of GPCR signaling.

PI_NAMEs: GARCIA-MARCOS, MIKEL  (contact)

PROGRAM_OFFICER_NAME: LEWIS, MECHELLE MAYLEBEN

PROJECT_TERMS: Acceleration;Achievement;Area;Asthma;Astrocytes;Biological;Biological Assay;Bioluminescence;Biosensor;Breeding;Cardiovascular Diseases;Cell Communication;Cell Line;Cell model;Cell Surface Receptors;cell type;Cells;Clinical;Cytoplasm;design;Detection;dimer;Disease;Dissociation;drug discovery;Drug usage;druggable target;Energy Transfer;Event;expectation;Experimental Models;extracellular;Family;Future;G Protein-Coupled Receptor Signaling;G-Protein-Coupled Receptors;Gene Delivery;Goals;GTP Binding;GTP-Binding Proteins;Guanosine Triphosphate;Heterotrimeric G Protein Subunit;Heterotrimeric GTP-Binding Proteins;Hormones;Human Genome;Hypersensitivity;improved;In Vitro;in vivo;interest;Malignant Neoplasms;Marketing;Measurement;Measures;Mediating;Membrane;Membrane Proteins;Methodology;Molecular;Mus;Names;Neurons;neuropsychiatric disorder;Neurotransmitters;novel;novel therapeutics;Opioid Analgesics;optical sensor;Optics;Pain management;Pathway interactions;Pharmaceutical Preparations;pharmacologic;Pharmacology;Physiological;Physiological Processes;Physiology;Primary Cell Cultures;Process;Protein Family;Proteins;prototype;receptor;Reporting;Reproducibility;Research;Research Personnel;Resources;response;sensor;Signal Transduction;stoichiometry;success;System;Technology;technology development;tool;Transfection;Transgenic Mice;Translations;vector;Viral Packaging;virtual

PROJECT_TITLE: Versatile and high-fidelity optical biosensor platforms for GPCR signaling

STUDY_SECTION: MCNP

STUDY_SECTION_NAME:
Molecular and Cellular Neuropharmacology Study Section
[MCNP]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Bioengineering;Genetics

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE Methods to inactivate specific genes in zebrafish are essential for uncovering basic insights into life, which translates into a better understanding of human development and disease. Existing methods for inactivating genes in zebrafish have limitations, including slow inactivation kinetics and the lack of combined spatial and temporal control. To overcome these problems, we propose to develop a set of protein depletion tools for zebrafish that will allow rapid protein inactivation with combined spatial and temporal control.

PI_NAMEs: KNAUT, HOLGER  (contact)

PROGRAM_OFFICER_NAME: STEIN, KATHRYN K

PROJECT_TERMS: Address;Binding;Biological;Biological Process;Body part;Cell Survival;Cells;Communities;Complex;Engineering;Event;F Box Domain;Fishes;fly;gene function;Gene Proteins;Gene Silencing;Genes;Genetic;Heat-Shock Response;Hormones;Hour;Human Development;human disease;improved;insight;interest;Investigation;Kinetics;Life;Light;loss of function;Mediating;Messenger RNA;Methods;model organism;Modification;nanobodies;Phenotype;promoter;protein degradation;protein function;Proteins;recruit;Research;Research Personnel;Role;Set protein;spatiotemporal;System;Tissues;tool;Transcription Coactivator;Translating;ubiquitin-protein ligase;Variant;Water;Work;Zebrafish

PROJECT_TITLE: Engineering Tools for Rapid Loss of Protein Function with Spatio-Temporal Control in Zebrafish

STUDY_SECTION_NAME: Development - 1 Study Section[DEV1]


ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative The Ras signaling network mediates diverse cellular functions and is often overactivated in diseases, such as developmental disorders and cancer. By studying its spatiotemporal dynamics, we will provide insights into the regulation of this signaling network in various cellular processes. The knowledge will facilitate the development of strategies to effectively reduce Ras signaling activity for disease treatment.

PI_NAMEs: HUANG, CHUAN-HSIANG  (contact)

PROGRAM_OFFICER_NAME: XU, JIANHUA

PROJECT_TERMS: Bar Codes;Biochemical;Biosensor;cancer cell;cell behavior;cell motility;Cell Nucleus;Cell Physiology;Cell Proliferation;cell type;Cells;Characteristics;Chemicals;Chemotactic Factors;Chemotaxis;Clinical;Complex;Cytoplasm;Cytoskeleton;Data;Development;developmental disease;Disease;Drug Combinations;EGF gene;Environment;Event;experimental study;fascinate;Feedback;Fluorescence Resonance Energy Transfer;Foundations;Goals;GTP-Binding Proteins;Guanosine Triphosphate Phosphohydrolases;Hela Cells;Image;Individual;insight;Knowledge;live cell imaging;Malignant Neoplasms;MAP Kinase Gene;mechanical stimulus;Mediating;Metabolic Diseases;Metabolism;Methods;migration;Modeling;Molecular;Monitor;Pathway Analysis;Pathway interactions;pharmacologic;Phosphatidylinositols;Phosphotransferases;Physiologic pulse;PIK3CG gene;Play;Population;Proliferating;Property;Proteins;PTK2 gene;real time monitoring;Refractory;Regulation;Reporting;Research;response;Role;self organization;sensor;Series;Signal Transduction;Signaling Molecule;Signaling Protein;SKOV3 cells;small molecule inhibitor;spatiotemporal;Stimulus;Structure;success;System;Techniques;Testing;Therapeutic Agents;Time;tool;Travel

PROJECT_TITLE: Deciphering the network structure of signaling dynamics

STUDY_SECTION: MIST

STUDY_SECTION_NAME: Molecular and Integrative Signal Transduction Study Section[MIST]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Social Determinants of Health

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

ORG_STATE: CA

PHR: PROJECT NARRATIVE  This K24 Mid-Career Development Award proposes to expand our current program of research by investigating the associations between financial fraud and Alzheimer’s Disease and Related Dementias (ADRD) in the Health and Retirement Study (HRS) and the Rush Alzheimer’s Disease Center (RADC) cohorts. A mentoring team consisting of USC and RADC faculty will provide the PI and trainees guidance in mentorship, professional development, and current research approaches with large datasets. Trainees will be provided with a wide range of research opportunities focused on financial vulnerability and cognitive/behavioral considerations in ADRD research.

PI_NAMEs: HAN, DUKE  (contact)

PROGRAM_OFFICER_NAME: NOVAK, PRISCILLA JOY

PROJECT_TERMS: Address;Age;age related decline;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Amyloid beta-Protein;Award;Behavioral;blood-based biomarker;Brain region;career;career development;Categories;Cognitive;cognitive ability;cognitive testing;cohort;Cohort Studies;Communities;contextual factors;Data;Data Set;Death Rate;density;Development;diverse data;Education;Elder Abuse;Enrollment;Episodic memory;equity, diversity, and inclusion;experience;Extramural Activities;Faculty;financial decision making;financial exploitation;Fraud;Functional Magnetic Resonance Imaging;Funding;gray matter;Health;Health and Retirement Study;Hippocampus;human old age (65+);Impaired cognition;Insula of Reil;K-Series Research Career Programs;large datasets;Link;literacy;Measures;Mediating;Mentors;Mentorship;Methods;mild cognitive impairment;Modeling;Neurobehavioral Manifestations;neurobiological mechanism;Neurobiology;Neuroepidemiology;neuroimaging;non-demented;older adult;Participant;Patients;Personal Satisfaction;pre-clinical;Predisposition;processing speed;programs;Protocols documentation;Psyche structure;Public Health;Race;racial difference;Research;Research Project Grants;Resources;Rest;Risk;Risk Factors;sex;Socioeconomic Factors;Structure;Surveys;tau Proteins;Training;United States;Work

PROJECT_TITLE: Mid-Career Development and Mentoring on Financial Vulnerability and Alzheimer's Disease

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development for Clinicians/Health Professionals Study Section [AGCD-3]


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Intellectual and Developmental Disabilities (IDD);Nutrition;Orphan Drug;Pediatric;Rare Diseases

ORG_CITY: PITTSBURGH

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Disorders of amino acid metabolism are identified by newborn screening and cause serious disease. This grant studies several of these disorders including isovaleric acidemia, maple syrup urine disease, propionic acidemia, and methylmalonic acidemia and attempt to identify promising new drugs to treat these disorders for clinical testing.

PI_NAMEs: VOCKLEY, GERARD  (contact)

PROGRAM_OFFICER_NAME: EGGERMAN, THOMAS L

PROJECT_TERMS: Acids;amino acid metabolism;Antioxidants;Architecture;Automobile Driving;Bioenergetics;Branched-Chain Amino Acids;Cardiolipins;Catabolism;Cells;chaperonin;Chemicals;Citric Acid Cycle;Co-Immunoprecipitations;Complex;Data;Defect;Disease;Distal;Electron Microscopy;Energy Metabolism;Enzyme Interaction;Enzymes;Fibroblasts;Functional disorder;Goals;Grant;Higher Order Chromatin Structure;Immunofluorescence Immunologic;improved;In Situ;Individual;inhibitor;Isoleucine;isovaleric acidemia;Isovaleryl-CoA dehydrogenase;Keto Acids;ketotic hyperglycinemia;Leucine;light microscopy;Maple Syrup Urine Disease;Metabolism;methylmalonic aciduria;methylmalonyl-CoA decarboxylase;Methylmalonyl-CoA Mutase;Mitochondria;mitochondrial dysfunction;Mitochondrial Matrix;mutant;Mutation;nanometer resolution;Nature;Neonatal Screening;novel;novel therapeutics;Oxidoreductase;Pathology;Pathway interactions;Patients;Peptides;Preclinical Drug Development;Production;protein complex;protein crosslink;Proteins;research clinical testing;Respiratory Chain;small molecule;small molecule inhibitor;Structure;Techniques;Therapeutic Agents;therapeutic development;therapy development;ultra high resolution;Valine;Visualization

PROJECT_TITLE: Characterization of Branched Chain Amino Acid Metabolism and Its Deficiency

STUDY_SECTION: TAG

STUDY_SECTION_NAME: Therapeutic Approaches to Genetic Diseases Study Section[TAG]


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Social Determinants of Health;Substance Misuse

ORG_CITY: PROVIDENCE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: PROJECT NARRATIVE Prescription medications are vital for the treatment of opioid use disorder (OUD) and comorbid medical and mental health conditions, which differentially affect people living with OUD. State prescription cap policies imposed on our most vulnerable populations, such as low-income Medicaid beneficiaries with OUD may force these populations to go without treatments or decide between treatments – a decision that may be particularly challenging for people with OUD who taking multiple medications, including medications for opioid use disorder (MOUD). In this mixed-methods study, we will analyze national Medicaid data to evaluate the impact of prescription cap policies on initiation and continuity of MOUD use among individuals diagnosed with OUD; determine the impact of prescription cap policies on health services utilization, overdoses, and all-cause mortality among individuals diagnosed with OUD; and contextualize our quantitative findings via interviews with patients with OUD and providers who practice in states impacted by cap policies to elucidate their experiences with caps and identify best practices for navigating these policies.

PI_NAMEs: DOW, PATIENCE MOYO;HUGHTO, JACLYN WHITE (contact)

PROGRAM_OFFICER_NAME: HAEGERICH, TAMARA

PROJECT_TERMS: access restrictions;Address;Adoption;Affect;Arkansas;Attention;beneficiary;Budgets;Buprenorphine;Caring;Characteristics;Chronic;chronic pain;Clinic;Clinical;comorbidity;cost;Cost Control;Data;Diagnosis;disability;Drug Prescriptions;Effectiveness;Enrollment;Epidemiologist;Equilibrium;evidence base;experience;General Population;Goals;Health;Health Care Costs;health goals;Health Policy;health service use;Health Services;HIV;Hospitalization;Hospitals;Improve Access;improved;Individual;Interview;Knowledge;Low income;marginalized population;Medicaid;Medical;medically necessary care;medication for opioid use disorder;Mental disorders;Mental Health;Methadone;methadone treatment;Methods;Morbidity - disease rate;mortality;Naltrexone;Names;novel;older adult;Opioid;opioid epidemic;opioid mortality;opioid use disorder;Outcome;Overdose;overdose death;Overdose reduction;Patients;Persons;Pharmaceutical Preparations;Pharmacists;Policies;Population;population health;Prevalence;Process;programs;Provider;Public Health;Qualitative Methods;Recommendation;Research;Research Personnel;response;Risk;severe mental illness;skills;Source;Subgroup;Tennessee;Texas;Time;Treatment Failure;Treatment outcome;United States National Institutes of Health;uptake;Vulnerable Populations;young adult

PROJECT_TITLE: Impact of Medicaid Prescription Cap Policies on Treatment Outcomes for Opioid Use Disorder: A National Mixed Methods Study

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HSS-B(90)S]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Genetics;Immunotherapy;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza

ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: Project Narrative Innovative treatment strategies are central to addressing the critical and growing problem of antibiotic resistance. One such strategy is to repurpose drugs (such as β-lactamase inhibitors) that can sensitize multidrug-resistant bacteria to killing by antimicrobial peptides of the innate immune system. The goal of this study is to investigate the mechanistic underpinnings for such synergy with the vision of harnessing these underappreciated therapeutic interactions to improve treatment outcomes for patients with multidrug-resistant infections.

PI_NAMEs: ULLOA, ERLINDA ROSE (contact)

PROGRAM_OFFICER_NAME: XU, ZUOYU

PROJECT_TERMS: Address;Affinity;Anti-Bacterial Agents;anti-microbial peptide;Antibiotic Resistance;Antibiotic Therapy;Antibiotics;antimicrobial;Award;bacterial genetics;Bacterial Infections;bacterial resistance;bactericide;beta-Lactamase;Binding;Binding Proteins;Biological Assay;Blood Platelets;Boston;California;career;Cell Death;Cell membrane;Cell surface;Cell Wall;Cells;Characteristics;Childhood;Clinical;combat;Combating Antibiotic Resistant Bacteria;Communicable Diseases;Complement;cytokine;Cytolysis;Development;DNA;Dose;drug discovery;drug repurposing;Drug resistance;drug resistant pathogen;Electrostatics;emerging antimicrobial resistance;Epithelial Cells;extracellular;Faculty;FDA approved;Fellowship;fitness;Fluorescence Microscopy;Foundations;Genetic;genome sequencing;Genomics;Goals;Hemophilus;Histopathology;Immune;immune clearance;Immunity;Immunology;immunoregulation;Immunotherapy;improved;In Vitro;in vivo;Infection;Inflammation;inhibitor;Innate Immune System;innovation;Investigational Therapies;Klebsiella;Klebsiella pneumoniae;Knock-out;Life;Lipids;Logic;Manuscripts;medical schools;Membrane;Mentors;Microbe;Microscopy;Modeling;Modern Medicine;Morphology;mouse model;Multi-Drug Resistance;multi-drug resistant pathogen;Multiple Bacterial Drug Resistance;Mus;mutant;Natural Immunity;neutrophil;novel;novel therapeutic intervention;novel therapeutics;pathogen;Pathogenesis;Patient-Focused Outcomes;Patients;Pattern;Pediatric Hospitals;Pediatrics;Penicillin Binding Protein 2;Penicillin-Binding Proteins;Peptide Antibiotics;Peptides;Peptidoglycan;Peptidyltransferase;Phagocytosis;Pharmaceutical Preparations;pharmacologic;Pharmacologic Substance;Philadelphia;Physicians;pneumonia model;Predisposition;Prevalence;Production;professor;Proteins;Pseudomonas;Public Health;Research;Research Personnel;Residencies;Resistance;resistance mutation;resistant Klebsiella pneumoniae;Resolution;Resources;Respiratory Burst;response;RNA;Rod;Safety;Scientist;Serial Passage;Shapes;skills;Surface Properties;synergism;Teacher Professional Development;Therapeutic;therapeutic target;Toxic effect;Training;Training Programs;Treatment outcome;treatment strategy;Universities;Vision;Vocational Guidance;whole genome;working group

PROJECT_TITLE: Beta-Lactamase Inhibitors Sensitize Multidrug-Resistant Gram-negative Pathogens to Innate Immune Clearance

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases B Research Study Section[MID-B]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Brain Disorders;Endocrine Disruptors;Neurodegenerative;Neurosciences;Parkinson's Disease;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human

ORG_CITY: EAST LANSING

ORG_DEPT: NEUROSCIENCES

ORG_NAME: MICHIGAN STATE UNIVERSITY

ORG_STATE: MI

PHR: Project Narrative Polyfluoroalkyl substances (PFAS) are anthropogenic chemicals and prominent soil and water contaminants with inherent resistance to environmental degradation, which warrants increased human exposure in decades to come. There exists mounting evidence pertaining to PFAS neurotoxicity, particularly dopaminergic cell loss, a central feature of Parkinson’s disease. The elucidation of underlying mechanism of neurotoxicity, alongside the development of an independent career, is expected to have a significant public health benefit.

PI_NAMEs: SAMMI, SHREESH RAJ (contact)

PROGRAM_OFFICER_NAME: HOLLANDER, JONATHAN

PROJECT_TERMS: Address;adverse outcome;Advisory Committees;alpha synuclein;Analytical Chemistry;Animals;anthropogenesis;Antioxidants;Biochemical;Bioenergetics;Biological;Biological Models;Brain;Caenorhabditis elegans;Carbon;career;career development;Carpet;Carrier Proteins;Cell Culture Techniques;Cells;Characteristics;Chemicals;comparative;Complex;Data;Defect;Dependence;Derivation procedure;Development;Development Plans;DNA Sequence Alteration;dopamine toxicity;Dopaminergic Cell;dopaminergic neuron;Dose;Environmental Health;Equipment;Etiology;Evaluation;Event;experimental study;exposed human population;Feedback;Fluorine;Future;gene environment interaction;Gene Expression;Genes;Genetic;Genus Hippocampus;Goals;Half-Life;Health;Health Benefit;Health Hazards;Human;human induced pluripotent stem cells;Impairment;In Vitro;in vitro Model;in vivo;Individual;induced pluripotent stem cell;Industrialization;Intervention;knock-down;Knowledge;Laboratories;Learning;Light;LRRK2 gene;Mediating;meetings;Mentors;Metals;Methods;Mitochondria;Nematoda;Nerve Degeneration;Neurodegenerative Disorders;neurodevelopmental effect;Neurons;neuropathology;neurotoxic;neurotoxicity;Oils;Organelles;Outcome;overexpression;Oxygen Consumption;Parkinson Disease;Pathologic;Pathology;Pathway interactions;Patients;perfluorooctane sulfonate;Pesticides;Phase;Poly-fluoroalkyl substances;Program Development;programs;Protein Import;Protons;Public Health;Publishing;Reactive Oxygen Species;Research;Resistance;Respiration;response;Risk;Risk Factors;Role;Series;skill acquisition;Soil;sporadic Parkinson's Disease;Stains;Structure;Structure-Activity Relationship;substance use;Sulfonic Acids;System;Techniques;Teratogenic effects;Testing;therapy design;Time;Toxic effect;toxicant;toxicant interaction;Training;Transgenic Organisms;translational impact;United States National Institutes of Health;uptake;Validation;Water;Water Pollutants;Whole Organism;Work

PROJECT_TITLE: Elucidation of mitochondrial mechanisms critical to mediating PFAS neurotoxicity

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: NARRATIVE Peru is a global center of training in public health and research in tropical medicine and the study of emerging diseases, but training and leadership is exclusively concentrated in the capital city of Lima and access to the training has largely bypassed academic institutions and professionals in Loreto, the largest department in the Peruvian Amazon. This D43 grant renewal seeks to continue to build research capacity to correct this disparity in opportunity by offering a collaborative research training program in partnership with the Universidad Nacional de La Amazonia Peruana (UNAP) complemented by skills training and research mentorship provided by the University of Virginia, Tulane University, and Universidad Peruana Cayetano Heredia. The goal of this training program is to train health researchers capable of leading research to diminish the burden of endemic and emerging infectious diseases in one of the highest burden areas for tropical and neglected diseases in the Americas.

PI_NAMEs: KOSEK, MARGARET N (contact);PAREDES OLORTEGUI, MARIBEL

PROGRAM_OFFICER_NAME: SINA, BARBARA J

PROJECT_TERMS: Address;Arizona;Biomedical Research;Bypass;Cities;Collaborations;Communicable Diseases;Communication;Communities;Counseling;data management;data visualization;design;Disparity;doctoral student;Educational Curriculum;Faculty;Fellowship;Field Workers;Fogarty International Center;Funding Agency;Future;global health;Goals;Grant;Health education;human subject;Infectious Diseases Research;Institution;Laboratories;Master of Science;Mentors;Peru;Peruvian;Physicians;programs;Public Health;public health research;Reproducibility;Research;Research Training;Role;Science;skills;Specialist;Students;technological innovation;Technology;Training;Training Activity;Training Programs;United States Department of Agriculture;Universities;Virginia;Writing

PROJECT_TITLE: Enabling Infectious Disease Research Capacity in the Peruvian Amazon

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DCAI-D(55)]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: TAMPA

ORG_NAME: H. LEE MOFFITT CANCER CTR & RES INST

ORG_STATE: FL

PHR: Project Narrative  KIR2DL2 is an inhibitory receptor whose role in T cell biology has been poorly characterized. The proposed research aims to validate KIR2DL2 as a new T cell immune checkpoint and to elucidate the signaling mechanism underlying its modulatory functions. The knowledge acquired through this project will be used to design novel and more efficient immunotherapies, including TIL, TCR-transgenic, and CAR-T cells, through manipulation of KIR2DL2 expression or function.

PI_NAMEs: ABATE-DAGA, DANIEL  (contact)

PROGRAM_OFFICER_NAME: CARDONE, MARCO

PROJECT_TERMS: Ablation;Adoptive Immunotherapy;Animal Model;Autoimmunity;Binding;Biological;Biological Assay;Biology;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Communication;Cell Death Induction;Cells;Cellular biology;chimeric antigen receptor;chimeric antigen receptor T cells;Clinical;Clonal Expansion;Clustered Regularly Interspaced Short Palindromic Repeats;Conditioned Reflex;cytokine;cytotoxic;Data;design;Docking;Education;effector T cell;Elements;engineered T cells;Event;General Population;Genes;Genetic;Genetic Transcription;genome editing;Genomics;Goals;HLA-C Antigens;Human;Immune;immune cell checkpoints;immune checkpoint;Immunoglobulins;Immunologic Surveillance;Immunoprecipitation;Immunotherapy;Impairment;improved;in vivo;Infusion procedures;Interferon Type II;ITIM;Killer Cells;killer immunoglobulin-like receptor;Knowledge acquisition;Ligands;Link;Liquid substance;Lymphocyte;Malignant neoplasm of pancreas;Malignant Neoplasms;manufacture;Measures;Mediating;Melanoma patient;Memory;Methods;Modeling;Modification;Molecular;Molecular Mechanisms of Action;mouse model;mutant;Natural Killer Cells;neoplastic cell;novel;Outcome;overexpression;pancreatic cancer model;Pathway interactions;Patient observation;Patients;Performance;pharmacologic;Pre-Clinical Model;prevent;Proteomics;Protocols documentation;PTPN6 gene;receptor;receptor binding;receptor expression;Research;Role;Shapes;Signal Pathway;Signal Transduction;Solid;Solid Neoplasm;T cell therapy;T-Cell Activation;T-Cell Receptor;T-Lymphocyte;Testing;Time;Transgenic Organisms;translational potential;tumor;tumor growth;Tyrosine;Up-Regulation;Virus Diseases;Western Blotting;Xenograft Model;γδ T cells

PROJECT_TITLE: KIR2DL2 Immune Checkpoint as Modulator of T-Cell Effector Function


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: Project narrative Computational modeling is a crucial tool to better understand how the brain produces cognition and behavior, and how individuals differ, both in healthy and psychiatric populations. However, a wide range of highly relevant models goes unexplored because our existing tools cannot apply to them. This project will develop widely applicable tools that will broadly extend the theories neuroscience researchers can explore quantitatively.

PI_NAMEs: COLLINS, ANNE G.E. (contact)

PROGRAM_OFFICER_NAME: KIM, EUNYOUNG

PROJECT_TITLE: Developing artificial neural network tools for cognitive modeling

STUDY_SECTION: HCMF

STUDY_SECTION_NAME: Human Complex Mental Function Study Section[HCMF]


ORG_DEPT: GENETICS

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: The genetic analysis of rare diseases across multiple studies has the potential to reveal novel causes of disease that might be missed in isolated study-speciﬁc analyses. Although the Gabriella Miller Kids First (KF) cohort has genetic and clinical data on almost 20,000 people who have, or who are related to someone who has, a birth defect or pediatric cancer, the cohort has not been analyzed jointly. We will develop and deploy a set of computationally efﬁcient and statistically powerful methods for discovering novel causes of rare diseases in KF and validate our results in other rare disease cohorts to which we have access.

PI_NAMEs: TURRO, ERNEST  (contact)

PROJECT_TERMS: Affect;Authorization documentation;Bioinformatics;Bite;Child;Clinical Data;clinical phenotype;cohort;Collaborations;Collection;Complex;Computing Methodologies;Congenital Abnormality;Congenital Disorders;Credentialing;Data;data access;Data Set;database schema;Databases;Discipline;Disease;Etiology;experience;forging;Foundations;Gene Frequency;Genes;Genetic;genetic analysis;genetic association;genetic pedigree;Genetic Predisposition to Disease;genetic variant;Genome;genome sequencing;genome wide association study;Genotype;Germ Lines;Hereditary Disease;Heterozygote;Human;indexing;Individual;insertion/deletion mutation;light weight;Malignant Childhood Neoplasm;Methods;Minor;Molecular;Natural Selections;Nature;novel;Ontology;Participant;Pathogenicity;Patients;Pediatric Cardiac Genomics Consortium;Persons;Phenotype;portability;Probability;proband;programs;Rare Diseases;rare variant;relational database;Research;Resources;Sampling;Side;Statistical Data Interpretation;Statistical Methods;Transcript;Validation;Variant;web app;web interface;whole genome;Work

PROJECT_TITLE: Bayesian genetic association analysis of all rare diseases in the Kids First cohort


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Social Determinants of Health

ORG_CITY: WASHINGTON

ORG_NAME: GERONTOLOGICAL SOCIETY OF AMERICA

ORG_STATE: DC

PHR: PROJECT NARRATIVE This R13 Research Conference application seeks funding to support pre- and post-doctoral level trainees from under-represented and diverse backgrounds to participate in a mentoring and career development pre-conference technical assistance workshops (MCDTAWS) at the annual scientific meetings of the Gerontological Society of America (GSA) from 2021 to 2025. This unique mentoring and career development training program is tailored to suit the needs of URM trainees interested in pursuing a career in gerontology. We are requesting support from the NIA to assist with the recruitment, inclusion, and training of talented trainees from URM backgrounds to participate in the GSA MCDTAW series.

PI_NAMEs: D'ANTONIO, PATRICIA M (contact);HEYN, PATRICIA C.;WHITFIELD, KEITH E.

PROGRAM_OFFICER_NAME: HARRELL, ERIN

PROJECT_TERMS: Address;Aging;aging population;Alzheimer's Disease;Applications Grants;Area;Award;Behavioral;Biological;Black race;career;career development;Caring;Child Care;Chronic Disease;Communication;design;Development;Disadvantaged;disadvantaged background;Discrimination;Disease;Education;Educational Curriculum;Educational workshop;Electronic Mail;empowerment;Ensure;Evaluation;Event;experience;Faculty;Family;Fellowship;Focus Groups;Funding;Gerontology;Goals;Grant;Growth;Health;health inequalities;Hispanic;Human;Human Rights;Infrastructure;innovation;interest;Lead;Leadership;Learning;lectures;Life;life span;meetings;Mentors;Methodology;Minority Groups;minority investigator;minority scientist;minority trainee;multidisciplinary;next generation;novel;Older Population;Outcome;Output;Paper;Pathway interactions;Peer Review;Policies;Population;Postdoctoral Fellow;pre-doctoral;Professional Organizations;programs;psychologic;psychosocial;Publications;Questionnaires;Readiness;recruit;Reporting;Research;Research Personnel;Resources;Risk;Role;Science;Scientist;Series;skills;social;social culture;social media;Societies;Students;Surveys;symposium;Talents;Terminal Disease;Time;tool;Training;Training Programs;Translations;Transportation;Travel;Underrepresented Minority;United States National Institutes of Health;webinar;welfare

PROJECT_TITLE: GSA MENTORING AND CARREER DEVELOPMENT TECHNICAL ASSISTANCE WORKSHOP

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Behavior and Social Science of Aging Study Section[NIA-S]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Networking and Information Technology R&D (NITRD);Prevention;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_NAME: FRED HUTCHINSON CANCER CENTER

PHR: PUBLIC HEALTH RELEVANCE STATEMENT The overall aim of this project is to determine the effectiveness of a conversational agent for smoking cessation. If successful, this intervention can be cost-effectively scaled on a population level, thereby making a high public health impact.

PI_NAMEs: BRICKER, JONATHAN B (contact)

PROGRAM_OFFICER_NAME: RODITIS, MARIA LEIA

PROJECT_TERMS: Abstinence;Address;Adopted;Adult;American;Antismoking;arm;behavior change;Cellular Phone;Cessation of life;chatbot;cigarette smoking;Cloud Computing;Communication;Communities;comparative effectiveness;Computers;cost;cost effective;cost effectiveness;Cost Measures;cost per quality-adjusted life year;demographics;design;diaries;digital;digital technology;Dissemination and Implementation;Effectiveness;effectiveness evaluation;Emotional;Feeling;follow-up;Goals;Health behavior change;improved;innovation;Internet;Intervention;Judgment;Knowledge;Language;Life;Machine Learning;Malignant Neoplasms;Measures;Mediating;Mediator;Medical;Modeling;Natural Language Processing;new technology;Outcome;Participant;patient engagement;Policy Maker;Policy Making;Population;premature;Prevalence;Process;programs;Public Health;public health relevance;Randomized;randomized effectiveness trial;randomized trial;Randomized, Controlled Trials;Research;response;Sample Size;sex;smartphone application;Smoker;Smoking;smoking cessation;Smoking Cessation Intervention;social;Social support;success;Technology;Testing;Text Messaging;text messaging intervention;Therapeutic;Time;Trust;web site;Work

PROJECT_TITLE: Full Scale Randomized Trial of an Innovative Conversational Agent for Smoking Cessation


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Liver Disease;Regenerative Medicine

ORG_DEPT: ANATOMY/CELL BIOLOGY

PHR: Narrative Liver transplantation is the only effective treatment for patients with end-stage liver diseases; however, the shortage of donor livers makes this therapy very limited. Comprehensive and detailed understanding of innate liver regeneration in diseased livers will provide significant insights into developing therapeutic strategies to promote liver regeneration in the patients. Our studies will delineate the molecular mechanisms underlying hepatocyte-to-cholangiocyte reprogramming-mediated biliary regeneration and suggest HDAC1/2 inhibitors as promising therapeutic drugs to promote the reprogramming-mediated regeneration in patients with cholestatic liver diseases.

PI_NAMEs: SHIN, DONGHUN  (contact)

PROGRAM_OFFICER_NAME: BURGESS-BEUSSE, BONNIE L

PROJECT_TERMS: beta catenin;Bile fluid;Biliary;biliary tract;Cell model;Cell Reprogramming;Characteristics;Chemicals;cholangiocyte;Cholestasis;Cirrhosis;Data;derepression;effective therapy;end stage liver disease;EP300 gene;Epithelial Cells;Exhibits;Fibrosis;gain of function;Gene Expression Regulation;Genes;Genetic;Genetic study;Goals;HDAC1 gene;Hepatic;Hepatocyte;Histone Acetylation;Image;inhibitor;Injury;innovation;insight;Intrahepatic bile duct;Life;Liver;Liver diseases;Liver Failure;liver injury;Liver Regeneration;liver transplantation;loss of function;Mediating;Modeling;Molecular;Morbidity - disease rate;mortality;MS-275;Mus;mutant;Natural regeneration;notch protein;novel;Obstruction;Pathway interactions;Patients;Pharmaceutical Preparations;pharmacologic;Pharmacology Study;Phenocopy;Process;Receptor Gene;Research;Role;Signal Transduction;small molecule;Stat3 protein;Testing;Therapeutic;tool;transdifferentiation;Zebrafish

PROJECT_TITLE: Delineating the molecular mechanisms of hepatocyte-to-cholangiocyte reprogramming

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


NIH_SPENDING_CATS: Cancer;Hematology;Rare Diseases

ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Project Narrative Although Multiple Myeloma (MM) causes devastating bone destruction and protracted suppression of bone formation, which increase mortality and contribute to MM cell drug resistance, there are no safe effective bone anabolic agents currently approved for MM. We identified p62 ( sequestosome1) as an important contributor to MM, and developed XRK, a small molecule that targets the p62-ZZ domain, which caused dramatic new bone formation in MM-bearing mice, induced MM cell death and enhanced the anti-MM effects of proteasome inhibitors (PIs) used for MM treatment in vitro. This proposal will investigate the mechanisms responsible for XRK’s effects in MM as a means to build bone, decrease tumor growth and develop new mechanism-based therapeutic agents for MM.

PI_NAMEs: CHIRGWIN, JOHN M (contact)

PROGRAM_OFFICER_NAME: HOWCROFT, THOMAS K

PROJECT_TERMS: Affinity;Anabolic Agents;antitumor effect;Apoptosis;Apoptotic;Autophagocytosis;Binding;bisphosphonate;bone;Bone Diseases;bone healing;Bone Marrow;Bone Pain;Bortezomib;Caspase;Cell Death;cell growth;Cells;Clinical;Collaborations;cytokine;Cytoprotection;Cytosol;Degradation Pathway;Drug resistance;Exposure to;Fracture;fracture risk;Goals;GRP78 gene;GTF2H1 gene;healing;improved;In complete remission;In Vitro;in vivo;Inflammatory;inhibitor;Lesion;Malignant Neoplasms;MAP Kinase Gene;Mediating;misfolded protein;Molecular;Molecular Chaperones;mortality;multicatalytic endopeptidase complex;Multiple Myeloma;Mus;N-terminal;New Agents;novel;osteoblast differentiation;Osteoblasts;Osteoclasts;Osteocytes;Osteogenesis;p38 Mitogen Activated Protein Kinase;Pathway interactions;Patients;Play;prevent;pro-apoptotic protein;Process;Proteasome Inhibitor;protein complex;protein degradation;Protein Fragment;Proteins;Proteolysis;proteotoxicity;receptor;recognins;Regulation;Resistance;Resistance development;RIPK1 gene;Signal Pathway;Signal Transduction;small molecule;Stress;Stromal Cells;System;Tertiary Protein Structure;Therapeutic Agents;therapeutic target;tumor growth;Ubiquitin;Universities

PROJECT_TITLE: Manipulating the N-end Rule Protein Degradation Pathway to Build Bone and Decrease Tumor Growth in Multiple Myeloma Bone Disease

STUDY_SECTION: SBDD

STUDY_SECTION_NAME: Skeletal Biology Development and Disease Study Section[SBDD]


PHR: NARRATIVE Cells control which proteins they synthesize in response to internal and external signals. We propose to learn the different ways that cells can initiate translation, and how these different pathways allow cells to regulate protein production. By learning how cells control protein synthesis, we will better understand how cells control growth and respond to stresses.

PI_NAMEs: INGOLIA, NICHOLAS T (contact)

PROGRAM_OFFICER_NAME: VATAKIS, DIMITRIOS NIKOLAOS

PROJECT_TERMS: Address;Automobile Driving;biological adaptation to stress;Cells;Choices and Control;Complement;Complex;Data;Development;Event;FRAP1 gene;Gene Expression;Genes;Growth;Human;in vivo;Individual;Initiator Codon;innovation;interest;Internet;Label;Learning;Link;link protein;MAP Kinase Gene;MAP Kinase Modules;MCT-1 gene;Mediating;messenger ribonucleoprotein;Messenger RNA;mRNA Stability;mRNA Translation;Pathway interactions;Peptide Initiation Factors;Phosphorylation;Phosphotransferases;Physiological;Physiology;PIK3CG gene;Poly A;Production;programs;Protein Biosynthesis;Protein Isoforms;protein protein interaction;Proteins;recruit;Regulation;response;Ribosomes;RNA;RNA-Binding Proteins;Role;Scanning;Signal Pathway;Signal Transduction;Site;Stress;Surveys;Tail;Transcript;transcriptome;translation factor;Translation Initiation;Translational Regulation;Translations

PROJECT_TITLE: Diverse and dynamically regulated mRNP composition regulating translation

STUDY_SECTION: GCAT

STUDY_SECTION_NAME: Genomics, Computational Biology and Technology Study Section[GCAT]


ORG_CITY: LA JOLLA

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative We propose to develop a systematic and high-throughput method for the engineering of specific and sensitive biosensors based on fluorescence resonance energy transfer (FRET). These biosensors will be applied to visualize the spatiotemporal patterns of histone methylations and chromatin structures at specific loci in single cells undergoing embryonic differentiation. The results should advance our fundamental understanding of stem cell regulation and embryonic development.

PI_NAMEs: WANG, YINGXIAO  (contact);ZHONG, SHENG

PROJECT_TERMS: 3-Dimensional;Acetylation;Affect;Architecture;Atlases;Biological Sciences;Biosensor;Cell Cycle;Cell Differentiation process;Cell Physiology;Cells;Cellular biology;cellular imaging;Chromatin;chromatin remodeling;Chromatin Remodeling Factor;Chromatin Structure;Code;Development;Directed Molecular Evolution;DNA biosynthesis;Embryo;embryo cell;Embryonic Development;encryption;endonuclease;Engineering;Epigenetic Process;Event;Evolution;Fluorescence Resonance Energy Transfer;Gene Expression;Gene Expression Profile;Gene Expression Regulation;Genetic Transcription;Genome;genomic locus;Genomics;Guide RNA;high throughput screening;Histone Acetylation;Histone Code;histone methylation;histone modification;Histones;Image;insight;Lead;Life;Light;Mammalian Cell;Maps;Masks;Methods;Methylation;Mitotic;Modeling;Modification;Molecular;Monitor;Mus;Mutagenesis;next generation sequencing;novel;Nuclear;Outcome;Pattern;Phenotype;Phosphorylation;Play;Population;Positioning Attribute;Pre-implantation Embryo Development;Process;programs;Proteins;recruit;Regenerative Medicine;Regulation;repaired;Reporting;Reproducibility;Resolution;RNA;Role;Signal Transduction;Site;spatiotemporal;stem cells;success;Technology;Testing;tool;Transcript;transcriptome;transcriptomic profiling;Visualization;Work

PROJECT_TITLE: Single Cell Tracking of 3D Epigenetic Landscape Evolution During Embryonic Development

STUDY_SECTION: CMT

STUDY_SECTION_NAME: Cellular and Molecular Technologies Study Section[CMT]


ADMINISTERING_IC: HL

ED_INST_TYPE: UNIVERSITY-WIDE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Aging;Cancer;Genetics;Hematology;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE The role of donor Clonal Hematopoiesis (CH) on hematopoietic cell transplant recipient outcomes and risk of future malignancies is poorly understood, as are the in vivo evolutionary dynamics that dictate the progression of CH to leukemia. Additionally, the patterns of CH clone distribution in stem and mature populations are unclear, limiting our insights into how to perform effective screening and risk assessment. Using a combination of cell phenotypic and genetic analysis, we will assay a unique longitudinal post-transplant and matched donor sample resource, focusing on cases with donor CH to examine the changes in clonal architecture over time, allowing us to gain insights into the risks in donor CH and leukemogenesis in general.

PI_NAMEs: STAUBER, JACOB  (contact)

PROGRAM_OFFICER_NAME: GILLASPY, ALLISON

PROJECT_TERMS: Acceleration;Affect;Age;Aging;Allogenic;Architecture;Biological Assay;Blood;Blood Cells;Blood specimen;Bone Marrow;Cardiovascular Diseases;cardiovascular disorder risk;Case Study;Cell Aging;Cell Differentiation process;Cell Separation;Cells;chronic graft versus host disease;Clonal Evolution;Clonal Expansion;Clonal Hematopoietic Stem Cell;Complication;conditioning;cytopenia;deep sequencing;Development;DNA;Donor Selection;dynamical evolution;Elderly;Environment;Epigenetic Process;Evolution;experience;follow-up;Future;Genes;genetic analysis;Genetic Transcription;Genotype;Goals;graft vs leukemia effect;Hematologic Neoplasms;Hematological Disease;Hematopoiesis;Hematopoietic;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;Hematopoietic System;in vivo;Individual;Inflammatory;inflammatory milieu;insight;interest;Label;Length;leukemia;Leukemic Cell;leukemogenesis;Malignant Neoplasms;mortality;mutant;Mutate;Mutation;Myeloproliferative disease;older patient;Older Population;Outcome;Pattern;peripheral blood;Persons;Phenotype;Population;post-transplant;premature;pressure;Prevalence;Process;progression risk;Proliferating;protein expression;Recording of previous events;Regimen;Relapse;relapse risk;Reporting;Residual state;Resources;response;Risk;Risk Assessment;Role;Sampling;screening;segregation;self-renewal;Siblings;Somatic Mutation;Sorting;stem;stem cell population;stem cells;Stimulus;Stress;Surface;System;telomere;Testing;Time;Transplant Recipients;Transplantation

PROJECT_TITLE: UNDERSTANDING STEM-CELL EVOLUTION DYNAMICS OF DONOR CLONAL HEMATOPOIESIS IN ALLOGENEIC HEMATOPOIETIC CELL TRANSPLANTATION AT A SINGLE-CELL LEVEL


NIH_SPENDING_CATS: Chronic Obstructive Pulmonary Disease;Clinical Research;Emphysema;Genetics;Human Genome;Lung;Prevention;Tobacco;Tobacco Smoke and Health

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Project Narrative Cigarette smoking causes variable degree of inflammation in the lung that only some smokers will develop chronic obstructive pulmonary disease (COPD). Genetic factors that increases the risk to develop COPD have been identified, but how genetic factors increase COPD risk and whether genetic factors contribute to inflammation is not well understood. We propose to investigate genetic mouse models and lung tissue samples and genetic data from COPD patients to understand how genetic factors influence inflammation in COPD. This study will help to identify novel therapeutic targets and provide insight into the pathology of COPD.

PI_NAMEs: YUN, JEONG H (contact)

PROGRAM_OFFICER_NAME: LU, QING

PROJECT_TERMS: Activated Lymphocyte;Address;Adoptive Transfer;Advisory Committees;Animal Genetics;Animal Model;Area;Award;biobank;Biometry;Candidate Disease Gene;candidate validation;Cause of Death;CD8-Positive T-Lymphocytes;Cells;chronic inflammatory lung disease;Chronic Obstructive Pulmonary Disease;cigarette smoking;Clinical;cohort;cytokine;Cytoprotection;Data;Data Set;Development;Disease;Disease susceptibility;disorder risk;Erinaceidae;exposure to cigarette smoke;Fibroblasts;follow-up;Frequencies;functional genomics;Gene Expression;Genes;Genetic;genetic epidemiology;Genetic Risk;genetic risk factor;Genetic Variation;genome wide association study;Genomics;Genotype;Goals;Heterogeneity;Histologic;Human;human subject;IL18 gene;Immune;immune activation;Immune response;Immune System Diseases;Immunologics;Immunology;In Vitro;in vivo;Individual;Infiltration;Inflammation;Inflammation Mediators;Inflammatory;Inflammatory Response;insight;Interferon Type II;Knockout Mice;Knowledge;Lead;Lung;Lung Diseases;Lymphocyte;Lymphocyte Activation;Lymphoid Follicle;Matrix Metalloproteinases;Mediating;Mentors;Mentorship;migration;Molecular;mouse model;Mus;new therapeutic target;Outcome;overexpression;Pathogenesis;Pathology;Patients;Phenotype;Physicians;Play;Predisposition;Process;Protein Deficiency;protein expression;Proteins;Pulmonary Emphysema;Pulmonary Inflammation;Reporting;Research;Research Proposals;response;Risk;risk variant;Role;Sampling;Scientist;Shapes;single cell sequencing;single-cell RNA sequencing;skills;Slice;Smoke;Smoker;Smoking;smoking exposure;Smoking History;Structure of parenchyma of lung;System;T cell infiltration;T-Cell Activation;therapy development;Tissue Sample;TNF gene;Training;Training Programs;transcriptome;United States;Validation;Variant;Work

PROJECT_TITLE: The role of COPD genetic risk factor HHIP on lymphocytic inflammation

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(OA)]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics

ORG_CITY: PALO ALTO

ORG_NAME: ENUMERIX, INC.

PHR: PROJECT NARRATIVE Currently, quantitative PCR (qPCR) is one of the most abundant DNA quantification tools available and is widely used in molecular diagnostics, such as COVID-19 test. The drawback to qPCR is that the data is not digitized and requires more test controls in order to interpret the results. Enumerix aims to circumvent this limitation by developing the next generation DNA quantification tool called direct count PCR (dcPCR) where the DNA data is digitized and rivals the sensitivity and dynamic range of qPCR in a cost effective manner.

PI_NAMEs: SHUM, ELEEN YEE LAM (contact)

PROGRAM_OFFICER_NAME: YU, GUOQIN

PROJECT_TERMS: 3-Dimensional;Architecture;Centrifugation;Chemistry;cost;cost effective;Coupled;COVID-19 test;Data;Deposition;design;Detection;Development;Device or Instrument Development;digital;DNA;Emulsions;Gene Expression Profiling;Goals;imager;improved;Industry;instrument;Laboratories;Light;liquid biopsy;manufacturability;Measurement;Methods;Molecular Biology;molecular diagnostics;multiplex detection;Mutation Detection;next generation;next generation sequencing;Noise;Oligonucleotides;Optics;Phase;Positioning Attribute;Production;prototype;rapid technique;rare variant;Reagent;RNA;Sampling;Scanning;Signal Transduction;software development;Speed;stability testing;Surveys;System;Techniques;Technology;Testing;tool;Tube;usability;web-based tool;Work

PROJECT_TITLE: Development of a high precision and high order DNA counting platform


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Prevention;Racial and Ethnic Minority Health Research

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PHR: Narrative Cardiometabolic diseases are on the increase worldwide, contributing to high levels of morbidity and mortality, with limited resources among lower-resource populations in North America and Africa to prevent disease, make diagnosis and clinically manage patients. In this study we bring together ~50,000 African-ancestry participants (African American, Jamaicans and continental African) to form the CARDINAL study to assess and develop polygenic risk scores for cardiometabolic diseases and traits, and to develop analytic approaches for multi-ethnic cohorts leveraging the increased genetic diversity and lower linkage disequilibrium in African genomes. This research will lead to a better understanding of the transferability of polygenic risk scores from discovery to target populations of different ethnicities, informing prevention and diagnostic strategies that could contribute to the development of effective public health policies.

PI_NAMEs: ADEBAMOWO, SALLY NNEOMA (contact);TAYO, BAMIDELE OLUSEGUN

PROGRAM_OFFICER_NAME: MINEAR, MOLLIE A

PROJECT_TERMS: Admixture;Affect;Africa;African;African American;African American population;African ancestry;Algorithms;Alleles;American;Biological;Blood Pressure;Body mass index;burden of chronic illness;Cardiometabolic Disease;cardiometabolism;Cardiovascular Diseases;Cause of Death;Clinical Management;clinical risk;cohort;Cohort Studies;Communicable Diseases;Complex;Country;Creatine;dashboard;Data;Data Collection;data harmonization;data integration;Data Set;data standards;Development;Diabetes Mellitus;Diagnosis;diagnostic strategy;Disease;disorder risk;diverse data;Dyslipidemias;Environment;Environmental Risk Factor;Ethnic Origin;Etiology;European;European ancestry;Funding;Gene Frequency;Genetic;Genetic Risk;Genetic Variation;Genome;genome wide association study;genomic data;Genomic Segment;genomic variation;Genomics;Genotype;Glucose;Guidelines;Health;health disparity;health inequalities;Health Policy;Heart Diseases;Heredity;Heterogeneity;Human;Hypertension;improved;Individual;insight;Insulin;interactive tool;Jamaican;Joints;Kidney Diseases;Knowledge;Lead;Life Style;lifestyle data;Linkage Disequilibrium;Lipids;machine learning method;member;Methods;Modeling;Morbidity - disease rate;mortality;multi-ethnic;North America;Northern Africa;novel;Obesity;Participant;Patients;Performance;Persons;Phenotype;phenotypic data;polygenic risk score;Population;Population Analysis;Population Heterogeneity;population stratification;Population Study;prevent;Prevention strategy;Process;Protocols documentation;Public Health;Publications;Quality Control;Research;Resources;Risk;Risk Factors;Scientist;Scoring Method;Signal Transduction;Site;Stroke;Structure;Target Populations;tool;trait;Translating;Trust;United States National Institutes of Health;Variant;Work;working group

PROJECT_TITLE: Polygenic Risk Score (PRS) Methods and Analysis for Populations of Diverse Ancestry - Study Sites


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Assistive Technology;Behavioral and Social Science;Bioengineering;Brain Disorders;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Dissemination and Implementation Research;Intellectual and Developmental Disabilities (IDD);Pediatric;Rehabilitation;Telehealth

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE In this proposal we will develop and pilot test a hybrid telehealth augmentative and alternative communication (AAC) intervention for toddlers with intellectual and developmental disabilities (IDD). Findings from this research have the potential to improve early communication interventions available to toddlers with IDD and their families.

PI_NAMEs: QUINN, EMILY DAYLE (contact)

PROGRAM_OFFICER_NAME: KOPF, LISA MARIE

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;Adoption;alternative communication;Augmentative and Alternative Communication;Behavior;Caregiver support;Caregivers;Child;Child Language;clinical practice;Clinical Trials;Communication;Communication impairment;community based treatment;Comprehension;critical period;Data;design;Development;Educational Activities;Educational process of instructing;effective intervention;effectiveness/implementation trial;elementary school;experience;Experimental Designs;experimental study;Exposure to;Family;Future;Geography;Goals;Home;Hybrids;implementation science;implementation strategy;improved;innovation;Instruction;Intellectual functioning disability;Intervention;intervention effect;Interview;Language;Language Development;language impairment;language outcome;Language Therapy;Learning;Learning Difficulty;literacy;Methods;Modeling;Modification;National Institute on Deafness and Other Communication Disorders;novel;Nursery Schools;Outcome;Parents;Participant;Pathologist;Persons;pilot test;Population;post intervention;preference;Preparation;primary outcome;Procedures;Qualitative Methods;Questionnaires;Research;Research Priority;secondary outcome;service delivery;Service delivery model;skills;social;Speech;telehealth;Testing;Text Messaging;therapy design;therapy development;Toddler;Transportation;treatment adherence;underserved community;Visual;Vocabulary;Work

PROJECT_TITLE: Early Augmentative and Alternative Communication (AAC) Intervention Delivered via Hybrid Telehealth

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Coronaviruses;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Infectious Diseases;Lung;Vaccine Related

ORG_CITY: BOSTON

PHR: Viral infections in the lung are cleared through a combination of humoral and cellular mediated immunity. Despite a large amount of effort, the cellular and molecular mechanisms controlling humoral and cellular mediated immunity to viruses is still unclear. The proposed studies will identify cellular and molecular mechanisms of how Follicular CD8 T cells control anti-viral immunity and vaccine efficacy to influenza and SARS-CoV-2.

PI_NAMEs: SAGE, PETER THE (contact)

PROGRAM_OFFICER_NAME: ARNOLD, MICHELLE MARIE

PROJECT_TERMS: 2019-nCoV;acute infection;Acute respiratory infection;Antibodies;Antibody Formation;Antibody Response;antiviral immunity;arm;Attenuated Vaccines;B-Lymphocytes;BLR1 gene;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Physiology;Cells;Cellular Immunity;Chronic;chronic infection;COVID-19 vaccination;Data;Development;effector T cell;Environment;Equilibrium;Evolution;genetic approach;Goals;Humoral Immunities;Immune response;Immune system;Immunity;Immunologic Memory;immunoregulation;in vivo;Individual;Infection;Influenza;influenza infection;inhibiting antibody;innovation;Intrinsic factor;Link;Lung;Lung infections;lymph nodes;Mediating;Memory;migration;Modeling;Molecular;Mus;novel;novel therapeutics;Outcome Study;Positioning Attribute;Property;reconstitution;Regulation;response;restraint;Role;SARS-CoV-2 antiviral;Signal Transduction;stem;Structure of germinal center of lymph node;T cell regulation;T memory cell;T-Lymphocyte Subsets;Testing;tool;transcription factor;Vaccination;vaccine efficacy;Viral Pathogenesis;Virus;Virus Diseases

PROJECT_TITLE: Control of Humoral and Cellular Immunity to Viral Infections of the Lung by Follicular CD8 T Cells

STUDY_SECTION: IHD

STUDY_SECTION_NAME: Immunity and Host Defense Study Section[IHD]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Chronic Pain;Neurosciences;Pain Research;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn

ORG_CITY: CINCINNATI

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF CINCINNATI

ORG_STATE: OH

PHR: Project Narrative  Projection neurons (PNs) in the spinal superficial dorsal horn are essential for nociceptive transmission to the brain and the generation of chronic pain after injury, and the long-term potentiation (LTP) of sensory synapses onto these neurons has been strongly linked to increased pain sensation. The expected outcomes of the proposed research will have a positive impact on public health by providing valuable insight into novel interventional strategies to disrupt spinal LTP as a means to alleviate chronic pain. In addition, by showing that neonatal surgical injury persistently facilitates LTP in adult PNs via changes in spinal dopamine signaling, these studies will provide much needed information regarding the potential mechanisms by which tissue damage in infants and children can alter pain sensitivity throughout life.

PI_NAMEs: BACCEI, MARK L (contact)

PROGRAM_OFFICER_NAME: GREENWELL, THOMAS

PROJECT_TERMS: Adult;Agonist;antagonist;behavior measurement;Brain;Child;chronic pain;Data;design;Dopamine;Dopamine Receptor;dorsal horn;druggable target;Electric Stimulation;Electrophysiology (science);Environment;Extracellular Signal Regulated Kinases;Fostering;G Protein-Coupled Receptor Signaling;G-Protein-Coupled Receptors;Generations;Genetic;genetic manipulation;Human;Immunohistochemistry;In Situ Hybridization;In Vitro;Infant;inhibitor;Injury;innovation;insight;Intervention;Investigation;Knowledge;Learning;Life;Link;Long-Term Potentiation;MAPK3 gene;Mediating;metabotropic glutamate receptor 5;Molecular;multidisciplinary;Mus;Neonatal;neonatal injury;neonatal surgery;Neuromodulator;Neurons;neuroregulation;Nociception;novel;Outcome;Output;Pain;Pain Measurement;pain perception;pain sensation;pain sensitivity;Pathway interactions;permissiveness;Persistent pain;Pharmaceutical Preparations;pharmacologic;postsynaptic;presynaptic;prevent;Protocols documentation;Public Health;receptor;Receptor Activation;Regulation;Relaxation;Research;Rodent;Sensory;Shapes;Signal Pathway;Signal Transduction;Spinal;Surgical incisions;Surgical Injuries;Synapses;Synaptic plasticity;Testing;Time;tissue injury;Tissues;transmission process;Work

PROJECT_TITLE: Neuromodulatory regulation of synaptic plasticity in spinal nociceptive circuits

STUDY_SECTION: NPI

STUDY_SECTION_NAME: Neurobiology of Pain and Itch Study Section [NPI]


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Women's Health Research

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: Project Narrative Triple-Negative breast cancer (TNBC) represents the subtype of breast cancer with worst prognosis and there is a lack of valuable therapeutic targets in this lethal disease. Here we provide evidence from unbiased screens that BBOX1 is a new therapeutic target in TNBC and genetic knockdown or pharmacological inhibition of BBOX1 leads to decreased TNBC cell fitness. The studies, if successful, will provide a new therapeutic avenue for TNBC and also provide a foundation for developing effective BBOX1 inhibitors for this lethal disease.

PI_NAMEs: ZHANG, QING  (contact)

PROGRAM_OFFICER_NAME: GHOSH-JANJIGIAN, SHARMISTHA

PROJECT_TERMS: 3-Dimensional;Affect;Agar;alpha ketoglutarate;Anabolism;Binding;Biochemical Reaction;Biological Assay;Breast;Breast Cancer Cell;Breast Cancer cell line;Breast Cancer Patient;Breast Cancer therapy;Breast Epithelial Cells;Calcium;Calcium Channel;Calcium Signaling;carcinogenesis;Carnitine;cell growth;Cell Proliferation;Cells;Clinical;clinically relevant;Custom;D Cells;Data;Death Rate;Defect;Development;Disease;Distant Metastasis;DNA;efficacy testing;Endoplasmic Reticulum;Enzyme Inhibitor Drugs;Enzymes;Epithelial Cell Proliferation;ERBB2 gene;experimental study;Family;Family member;fitness;Foundations;Genetic;Glycolysis;Growth;histone demethylase;Hydroxylation;Hypoxia;Impairment;In Vitro;in vivo;inhibitor;inorganic phosphate;Inositol;knock-down;Levocarnitine;Libraries;Malignant Breast Neoplasm;Malignant Neoplasms;Mediating;Metabolism;Mitochondria;Mixed Function Oxygenases;Molecular;new therapeutic target;novel;novel therapeutics;Oncogenic;orthotopic breast cancer;overexpression;Oxygen;Pathogenesis;Pathway interactions;patient derived xenograft model;Patient-derived xenograft models of breast cancer;Patients;pharmacologic;Phenotype;prevent;Process;Procollagen-Proline Dioxygenase;Prognosis;Proteins;receptor;Recording of previous events;Reporting;Respiration;Role;screening;Signal Transduction;Small Interfering RNA;Testing;Therapeutic;therapeutic target;Tissue Microarray;triple-negative invasive breast carcinoma;tumor growth;tumor metabolism;tumorigenesis;Ubiquitination;Xenograft Model

PROJECT_TITLE: BBOX1 is a Novel Oncogenic Driver in Triple Negative Breast Cancer

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 2 Study Section[MCT2]


NIH_SPENDING_CATS: Cancer;Immunotherapy

ORG_CITY: HOUSTON

ORG_NAME: METHODIST HOSPITAL RESEARCH INSTITUTE

PHR: Project Narrative In this project we will determine the roles of specialized white blood cells, called tumor-specific interleukin 9- producing T cells, in promoting an immune response against solid tumors in mice and determine their potential for use in cancer adoptive cell immunotherapy. We hypothesize that transfer of these tumor-specific T cells will eradicate large established tumors and prevent recurrence in vivo in both mouse and human tumor models, due to their ability to 1) directly kill the tumor cells; 2) penetration into stroma-rich solid tumors, and 3) restrain relapse caused by acquired resistance due to high heterogeneity in tumor antigen expression.

PI_NAMEs: LU, YONG  (contact)

PROGRAM_OFFICER_NAME: LIU, YIN

PROJECT_TERMS: Adoptive Cell Transfers;Adoptive Immunotherapy;Antigen Targeting;Antigens;cancer cell;Cancer Model;CD4 Positive T Lymphocytes;Cells;chimeric antigen receptor;Clinical;Clinical Trials;Data;Disease remission;Dose;effector T cell;Endogenous Retroviruses;Endowment;Ensure;Enzymes;exhaust;extracellular;Extracellular Matrix;Foundations;Future;Genes;Helper-Inducer T-Lymphocyte;Heterogeneity;Human;Immune response;Immunity;in vivo;Infiltration;innovation;Interferon alpha;Interleukin-9;Leukocytes;Malignant neoplasm of ovary;Malignant Neoplasms;Mediating;Melanoma;MME gene;Modeling;monocyte;mouse model;Mus;neoplastic cell;novel;Patients;Penetration;Phenotype;PPBP gene;pre-clinical;prevent;Production;proto-oncogene protein Spi-1;Recurrence;Relapse;Resistance;response;restraint;Role;Signal Transduction;Solid Neoplasm;stemness;T-Cell Proliferation;T-Cell Receptor;T-Lymphocyte;T-Lymphocyte Subsets;Therapeutic Index;therapy resistant;TLR3 gene;TRAF6 gene;tumor;Tumor Antigens;tumor eradication;tumor heterogeneity;Work

PROJECT_TITLE: The Unique Roles of Tumor-Specific Th9 Cells for Solid Tumor Eradication

STUDY_SECTION: CII

STUDY_SECTION_NAME: Cancer Immunopathology and Immunotherapy Study Section[CII]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Contraception/Reproduction;Endocrine Disruptors;Estrogen;Women's Health Research

ORG_CITY: WEST LAFAYETTE

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: PURDUE UNIVERSITY

PHR: PROJECT NARRATIVE This proposal will investigate the role of the sex hormone estrogen in regulating the effects of vocal fold dehydration in males and females. This proposal will determine the protective effects of estrogen in reducing adverse consequences of vocal fold dehydration, and examine the influence of estrogen on the blood supply to the voice box and vocal folds.

PI_NAMEs: COX, ABIGAIL ;SIVASANKAR, PREETI M. (contact)

PROJECT_TERMS: Acoustics;Address;Adult;adverse outcome;Affect;Air Movements;Animal Model;Animals;Automobile Driving;awake;Behavioral;behavioral outcome;Biological;biological sex;Biology;Biomechanics;Blood flow;Blood Vessels;Clinical;clinically significant;Data;Dehydration;Desire for food;Discipline;Doppler Ultrasound;Equilibrium;Estradiol;Estrogen Receptors;Estrogen Replacements;estrogenic;Estrogens;Exposure to;Female;Food;functional outcomes;Geometry;Goals;Gonadal Steroid Hormones;hemodynamics;Histologic;Histology;Hormonal;Hormone Receptor;Hormones;Hydration status;in vivo;innovation;insight;intersectionality;Investigation;Knowledge;Larynx;laser capture microdissection;Magnetic Resonance Angiography;male;Measures;Mechanical Stress;Menopause;Modeling;Modification;Molecular;Molecular Profiling;Morphology;Mucous Membrane;Muscle;National Institute on Deafness and Other Communication Disorders;Operative Surgical Procedures;Orchiectomy;Organ;Outcome;Outcome Measure;Ovariectomy;Physiological;Physiology;Placebos;Positioning Attribute;Property;protective effect;Proteome;Publishing;Rattus;Recommendation;Regulation;reproductive organ;Research;Research Design;response;Rewards;Role;sex;Strategic Planning;Study models;Tissues;transcriptome;Ultrasonics;Vascular blood supply;vocal cord;vocalization;Voice;Water;xenoestrogen

PROJECT_TITLE: Estrogenic regulation of systemic vocal fold dehydration

STUDY_SECTION: MFSR

STUDY_SECTION_NAME: Motor Function, Speech and Rehabilitation Study Section[MFSR]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: DAVIS

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: PROJECT NARRATIVE – OVERALL Despite strong links between maternal infection and neurodevelopmental disorders, little is known about why some pregnancies are susceptible, and others resilient, to this risk factor and why the susceptible pregnancies lead to a wide range of distinct disorders in humans. Using a newly discovered approach that predicts outcomes, we will measure changes in maternal immunity and cortico-striatal circuits in five highly interactive projects using mouse and NHP models of MIA and individuals with schizophrenia, to determine factors in the mother and offspring that contribute to susceptibility and resilience to different phenotypic outcomes. If successful, our results will identify causal molecular pathways in specific neural circuits critical for developing interventions optimized for the developmental age and sex of at-risk offspring following MIA, as well as biomarkers to predict pregnancies most at risk and approaches to prevent behavioral aberrations in offspring.

PI_NAMEs: BAUMAN, MELISSA DAWN (contact);CARTER, CAMERON S.

PROGRAM_OFFICER_NAME: ZALCMAN, STEVEN J

PROJECT_TERMS: Address;Adolescence;Affect;Age;Age Months;at-risk pregnancies;Behavioral;behavioral outcome;behavioral phenotyping;Biological Markers;biological sex;biomarker development;Brain;brain abnormalities;clinically relevant;cognitive control;cognitive disability;Computer Models;Corpus striatum structure;Coupled;COVID-19 pandemic;Development;Diffusion Magnetic Resonance Imaging;Disease;Dopamine;Early Intervention;Female;Functional Magnetic Resonance Imaging;Funding;Gene Expression;Heterogeneity;Human;Image;Immune;immune activation;Immune response;Immune signaling;immunoreactivity;in vivo;Incidence;Individual;Infection;Intervention;Knowledge;Lead;Link;Magnetic Resonance Spectroscopy;male;maternal immune system;Maternally-Acquired Immunity;Measures;Mediating;Mental disorders;Modeling;Molecular;Mothers;Motivation;mouse model;Mus;neural;neural circuit;Neuroanatomy;Neurodevelopmental Disorder;neuroimaging;Neuroimmune;Neuroimmunomodulation;neuromelanin;neuropsychiatric disorder;non-genetic;nonhuman primate;novel therapeutics;offspring;optogenetics;Outcome;outcome prediction;Pathway interactions;Patients;Phenotype;Poly I-C;Population;postnatal period;predictive modeling;Predisposition;Pregnancy;prevent;Psychopathology;Research;Research Personnel;resilience;response;Risk;Risk Factors;Rodent Model;Schizophrenia;schizophrenia risk;sex;Sex Differences;Signal Pathway;single cell genomics;sobriety;Symptoms;Testing;Therapeutic Intervention;therapy development;Time;transcriptomics;young adult

PROJECT_TITLE: UC Davis Conte Center: Neuroimmune Mechanisms of Psychiatric Disorders


NIH_SPENDING_CATS: Brain Disorders;Mental Health;Mental Illness;Neurosciences

PI_NAMEs: BAUMAN, MELISSA DAWN (contact)

PROJECT_TERMS: Area;Awareness;Biostatistics Core;Brain;Collaborations;Communication;Communities;continuing medical education;Development;Education;Education and Outreach;Electronic Mail;Ensure;Evaluation;Event;Face;Fostering;Goals;graduate student;Group Meetings;Health;Individual;informal learning;interest;Knowledge;lectures;Measures;meetings;member;Mental disorders;Mental Health;Mind;National Institute of Mental Health;neuroimaging;Neuroimmunomodulation;Neurosciences;next generation;Occupational activity of managing finances;organizational structure;Outcome;outreach;Persons;Play;post-doctoral training;Postdoctoral Fellow;pre-doctoral;programs;Progress Reports;Psychiatry;Psychotic Disorders;recruit;Reporting;Research;Research Personnel;Research Project Grants;Resources;Role;Schools;Series;Services;Societies;symposium;Training;Training Activity;Training Programs;Videoconferencing;web site;Work

PROJECT_TITLE: UC Davis Conte Center: Administrative Core


ORG_CITY: LOUISVILLE

ORG_NAME: UNIVERSITY OF LOUISVILLE

ORG_STATE: KY

PHR: PROJECT NARRATIVE Chronic inflammation is a central feature in the development of obesity-induced insulin resistance and type 2 diabetes. Although physical activity protects against adiposity and chronic inflammation, the cellular mechanisms remain undefined. We will assess how exercise and diet contribute to the development of adipose tissue inflammation and diet-induced insulin resistance.

PI_NAMEs: PENA CALDERIN, ERNESTO HECTOR (contact)

PROGRAM_OFFICER_NAME: BODDIE, THOMAS ARTIS

PROJECT_TERMS: Academia;Adipocytes;Adipose tissue;Adrenal Glands;Adrenergic Agents;Adrenergic Receptor;Anabolism;Animals;Arachidonate 5-Lipoxygenase;Arterial Fatty Streak;cardiorespiratory fitness;Catecholamines;CD59 Antigen;Cells;Cessation of life;Chronic;Chronic Disease;Consumption;Crowns;cytokine;Data;Development;Diabetes Mellitus;Diabetic mouse;Diet;diet and exercise;Enzymes;Exercise;feeding;Functional disorder;Glucose;glucose uptake;Goals;High Fat Diet;Immune;Immunohistochemistry;Immunosuppression;improved;Individual;Infiltration;Inflammation;Inflammatory;inflammatory marker;Inflammatory Response;Innate Immune Response;insight;Insulin Receptor;Insulin Resistance;insulin sensitivity;Interruption;Knowledge;Laboratories;Learning;Leukotriene B4;lipid mediator;lipidomics;Lipoxins;LTB4R gene;Macrophage;Macrophage Activation;magnetic beads;Measures;Mediating;Metabolism;Molecular;Mus;Non-Insulin-Dependent Diabetes Mellitus;Nutrient;Obesity;obesity development;Pathway interactions;Phenotype;Physical activity;physical inactivity;Polyunsaturated Fatty Acids;premature;prevent;Process;Production;Prostaglandin-Endoperoxide Synthase;receptor expression;Research Personnel;Resistance development;Resolution;response;sedentary;Signal Pathway;Signal Transduction;skills;Sorting;Structure;systemic inflammatory response;Techniques;Testing;Therapeutic;Tissue Expansion;Tissues;Weight;Work;wound healing

PROJECT_TITLE: High fat diet-induced adrenergic dysfunction and resolution of adipose inflammation


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

ORG_CITY: COLUMBIA

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

ORG_STATE: MO

PHR: PROJECT NARRATIVE: The role of cardiac vagal motor neurons in the regulation of cardiovascular function has long been established, but the contribution of this system to cardiovascular dysregulation during the consumption of foods high in fat is an understudied topic. These experiments will address the hypothesis that consumption of foods high in fat significantly elevate inhibition of brainstem vagal motor neurons responsible for the generation of vagal motor drive to the heart. This proposal develops a novel neuromechanistic model by which a microcircuit within the brainstem underpins increased vagal inhibition after the consumption of a diet high in fat.

PI_NAMEs: BOYCHUK, CARIE RENEE (contact)

PROGRAM_OFFICER_NAME: TJURMINA, OLGA A

PROJECT_TERMS: Adrenergic Receptor;Affect;American;Animals;Axon;Biological;biomarker discovery;Bradycardia;Brain Stem;Calories;Cardiac;Cardiovascular Diseases;cardiovascular disorder risk;Cardiovascular Physiology;Cardiovascular system;Cell Nucleus;Cells;Characteristics;Chemoreceptors;Complex;Consumption;Data;Dependence;Diet;Disease;Early identification;Electrocardiogram;Electrophysiology (science);experimental study;Fatty acid glycerol esters;food consumption;Functional disorder;gamma-Aminobutyric Acid;Ganglia;Generations;Genetic;Glutamates;Health;Heart;Heart failure;heart function;Heart Rate;High Fat Diet;Hypertension;Image;innovation;knock-down;Knowledge;Laboratories;Mass Spectrum Analysis;Mediating;Mediator;Modality;Modeling;Molecular;Monitor;Morbidity - disease rate;mortality;Motor;Motor Activity;motor neuron function;Motor Neurons;Mus;Myocardial dysfunction;Neuronal Dysfunction;Neurons;neurophysiology;neurotransmission;new therapeutic target;Nodal;noradrenergic;novel;nucleus ambiguus;Obesity;optogenetics;overexpression;patch clamp;pharmacologic;Pharmacology;Physiology;Play;Pressoreceptors;prevent;Protein Inhibition;Protein Isoforms;Protein Kinase C;receptor;Reflex action;Regulation;response;Rest;restraint;Reverse Transcriptase Polymerase Chain Reaction;Risk;Role;Sensory;Signal Transduction;Symptoms;Synaptic Receptors;System;Telemetry;Testing;Time;transcriptomics;Transgenic Mice;Transgenic Organisms;Viral;Work

PROJECT_TITLE: The Impact of High Fat Diet on Brainstem Vagal Regulation

STUDY_SECTION: IVPP

STUDY_SECTION_NAME: Integrative Vascular Physiology and Pathology Study Section[IVPP]


NIH_SPENDING_CATS: Brain Disorders;Immunization;Mental Health;Mental Illness;Neurosciences;Prevention;Women's Health Research

PI_NAMEs: VAN DE WATER, JUDY A. (contact)

PROJECT_TERMS: Address;Adult Children;Affect;Animal Model;Automobile Driving;Behavior;Behavioral;behavioral outcome;behavioral phenotyping;Biological Markers;biomarker identification;Brain;Brain Diseases;C57BL/6 Mouse;Cells;chemokine;Corpus striatum structure;COVID-19 pandemic;cytokine;Development;Disease;Dopamine;Dose;Early Diagnosis;Early treatment;endophenotype;Epigenetic Process;Etiology;Exhibits;experimental study;Female;Fever;Future;Goals;High Risk Woman;Human;human disease;Immune;immune activation;Immune response;Immune signaling;Immunologic Factors;Immunologic Markers;Immunologic Tests;Immunologics;immunoreactivity;Infection;Inflammatory;Injections;interest;Interleukin-6;Intrinsic factor;Knowledge;Lead;Link;Maternally-Acquired Immunity;Measures;Mediating;Mental disorders;Modeling;Modification;Molecular;Molecular Target;Monkeys;mouse model;Mus;neural circuit;neurodevelopment;Neurodevelopmental Disorder;Neuroimmunomodulation;neuropathology;nonhuman primate;offspring;Pathway interactions;Peripheral;Poly I-C;predictive marker;Predisposition;Pregnancy;prevent;Production;resilience;response;Risk;Risk Factors;Schizophrenia;Serum;sex;Signal Pathway;Signal Transduction;success;Testing;Time;Viral;Virus Diseases

PROJECT_TITLE: Project 1: Maternal Immunity in MIA susceptibility


ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

NIH_SPENDING_CATS: Behavioral and Social Science;Child Abuse and Neglect Research;Childhood Injury;Clinical Research;Drug Abuse (NIDA only);Mental Health;Pediatric;Prevention;Social Determinants of Health;Substance Misuse;Substance Misuse Prevention;Violence Research;Youth Violence

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

PHR: PROJECT NARRATIVE Child maltreatment and adolescent substance use are highly-prevalent and tightly-connected public health concerns in the United States. The current study aims to identify the pathways from child maltreatment to adolescent substance use by focusing on risky and protective attributes within youth activity spaces as critical underlying mechanisms. Findings from the proposed research will inform the development of more effective interventions to prevent substance use among high-risk youth by elucidating key contextual mechanisms and protective factors for adolescent substance use following child maltreatment.

PI_NAMEs: YOON, SUSAN H. (contact)

PROGRAM_OFFICER_NAME: VIDAL, SARAH

PROJECT_TERMS: Acceleration;Address;Adolescence;Adolescent;Adolescent Development;adolescent health;adolescent substance use;Area;Behavioral;behavioral health;Buffers;career;career development;Child;Child Abuse and Neglect;Child Welfare;Chronic;Communities;comorbidity;Complex;County;Creativeness;Data;Data Linkages;Data Sources;Development;Development Plans;diverse data;Doctor of Philosophy;Drug usage;effective intervention;Environmental Exposure;experience;Exposure to;Fostering;Gender;Goals;Health;high risk;improved;Individual;Information Systems;innovation;insight;Intervention;Investigation;Knowledge;Learning;Life Cycle Stages;Link;Location;Longitudinal cohort study;Longitudinal Studies;maltreatment;Mediating;Mental Depression;Mentored Research Scientist Development Award;Mentors;Methodology;multilevel analysis;multiple data sources;National Institute of Drug Abuse;novel;Ohio;Outcome;Pathway interactions;Pattern;pediatric trauma;person centered;Persons;Pharmaceutical Preparations;Play;polysubstance use;polyvictimization;prevent;Prevention;promote resilience;protective factors;psychosocial;Public Health;Qualifying;Records;Research;Research Activity;Research Personnel;Research Priority;Research Support;resilience;Risk;Risk Factors;Role;Scientist;Sex Differences;Shapes;Site;skills;social;Social Controls;social factors;statistics;Substance Addiction;substance use;Substance Use Disorder;substance use prevention;theories;Training;Training Activity;Trauma;trauma symptom;Trust;United States;Violence;Visit;willingness;Work;Youth

PROJECT_TITLE: Risk and Resilience to Adolescent Substance Use: The Roles of Child Maltreatment and Youth Activity Space

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


NIH_SPENDING_CATS: Genetics;Neurosciences;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE  During neural development, neuronal stem cells produce neurons that ultimately wire-up to form circuits that process somatosensory information (e.g., touch, temperature, pain). The current proposal will identify molecules that instruct neurons from a single neuronal stem cell to populate different somatosensory circuits. This knowledge is critically required to produce therapies for injuries and diseases affecting somatosensation.

PI_NAMEs: HENDERSON, JAKE  (contact)

PROGRAM_OFFICER_NAME: KIM, JENNY LILY

PROJECT_TERMS: 3-Dimensional;Adopted;Affect;Afferent Neurons;Animals;Architecture;Area;Axon;axon guidance;Biological Assay;Birth Order;cell type;confocal imaging;Confocal Microscopy;Cues;Data;Daughter;Dendrites;Development;differential expression;Disease;Disparate;Drosophila genus;Drosophila melanogaster;Environment;Family;Gene Expression;genetic manipulation;Injury;innovation;Interneurons;Knowledge;Label;Lateral;Ligands;Location;loss of function;Maps;Modeling;Molecular;Morphogenesis;Morphology;Nerve;nerve stem cell;Nervous System;neuroblast;neurodevelopment;neuron development;neuronal circuitry;Neurons;Pain;Pathology;Peripheral Nervous System;Positioning Attribute;postmitotic;Process;Proprioceptor;receptor;receptor expression;Receptor Gene;Receptor Signaling;Regulation;Role;Rosaniline Dyes;self-renewal;Signaling Molecule;single-cell RNA sequencing;somatosensory;Specific qualifier value;stem cells;Synapses;System;Temperature;Testing;therapy development;Tissue-Specific Gene Expression;tool;Touch sensation;transcription factor;Work

PROJECT_TITLE: How temporal transcription factors regulate guidance cues and dendrite morphogenesis in Drosophila somatosensory circuits


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Mental Illness;Neurosciences;Prevention;Schizophrenia

PI_NAMEs: HANKS, TIMOTHY D. (contact)

PROJECT_TERMS: Address;Adult Children;Affect;Animal Model;Behavior;Behavioral;behavioral outcome;behavioral phenotyping;Biological Assay;Brain;Brain Diseases;Clinical;cognitive control;computer framework;Computer Models;Corpus striatum structure;cytokine;Cytokine Signaling;Data;Development;Disease;Dorsal;Dose;Early Diagnosis;Early treatment;Elements;Equilibrium;executive function;Exposure to;Female;Funding;Future;Goals;Heterogeneity;Human;human disease;Immune;immune activation;Immunologic Factors;immunoreactivity;Infection;Inflammatory;Injections;Interleukin-10;Interleukin-6;Intervention;Intrinsic factor;Knowledge;Laboratories;Lead;Link;male;Measures;Mediating;Mental disorders;Modeling;Molecular;Molecular Target;Motivation;mouse model;Mus;neural circuit;Neurodevelopmental Disorder;Neuroimmunomodulation;neuropathology;neuropsychiatric disorder;nonhuman primate;novel;offspring;optogenetics;Outcome;Pathway interactions;Patients;Phase;Phenotype;Poly I-C;Predisposition;Pregnancy;prevent;Prevention;Prevention strategy;Proteins;repetitive behavior;resilience;reward processing;Rewards;Risk Factors;Schizophrenia;sensor;Shapes;side effect;success;targeted treatment;Testing;Time;treatment strategy;Ventral Striatum;Viral

PROJECT_TITLE: Project 2: Striatal circuits in MIA phenotypic heterogeneity