NIH_SPENDING_CATS: American Indian or Alaska Native;Building Research Capacity at Institutions with Limited NIH Funding;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research

PI_NAMEs: GREENSKY, CRYSTAL DAWN, (contact)

PROJECT_TERMS: Advisory Committees;American Indian Population;Chippewa;Collaborations;Communication;Communities;community involvement;Data;Data Protection;Development;Documentation;Education;Employment Opportunities;empowerment;Ensure;Evaluation;Event;Fond du Lac;Fostering;Goals;Grant;Health;health disparity;Human Subject Research;Infrastructure;Institution;Institutional Review Boards;Interview;Knowledge;Leadership;member;Monitor;Procedures;Productivity;Program Development;Protocols documentation;Research;Research Activity;research and development;Research Institute;Research Project Grants;Resources;Role;Safety;Services;Social Well-Being;Strategic Planning;Structure;Students;Surveys;synergism;System;Training;Training Activity;training project;Travel;tribal community;Tribes;Universities;web site;Work

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BDCN-N]


ADMINISTERING_IC: GM

ARRA_FUNDED: N

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: CLOQUET

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: FOND DU LAC RESERVATION

ORG_STATE: MN

PROJECT_TERMS: Address;adverse outcome;Agreement;biomedical resource;Chippewa;Clinic;Code;Collaborations;Communication;Communities;community building;community clinic;community partners;community research;Copyright;cultural competence;Data;data management;data repository;data sharing;Development;Educational Curriculum;Educational process of instructing;Educational workshop;Ensure;epidemiologic data;Epidemiology;Ethics;Exercise;experience;Faculty;Fond du Lac;Fostering;Foundations;Funding;Health;health data;health disparity;health training;Housing;human subject;Human Subject Research;improved;Indigenous;indigenous community;innovation;Institutional Review Boards;Intellectual Property;Intervention;Knowledge;member;Mentors;Mentorship;Modeling;Native American community;Native American Research Center for Health;Outcome;Ownership;Perception;Persons;Policies;Population;Prevention;Privacy;Procedures;Property Rights;Publications;Recording of previous events;Regulation;Reporting;Research;Research Ethics;Research Infrastructure;Research Institute;Research Personnel;Research Project Grants;Research Support;Security;Site;social;Students;Surveys;System;Training;training data;tribal community;tribal institution;tribal organization;Tribes;webinar

PROJECT_TITLE: Capacity-Building


ADMINISTERING_IC: CA

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Immunotherapy;Radiation Oncology

ORG_CITY: BUFFALO

ORG_NAME: ROSWELL PARK CANCER INSTITUTE CORP

ORG_STATE: NY

PHR: PROJECT NARRATIVE Radiation therapy is one of the pillars of cancer treatment as approximately half of all cancer patients receive radiation therapy. The overarching goal of this R35 research program is to widen the therapeutic window of radiation therapy by using sophisticated genetically engineered mice, human sarcoma cell lines, and sarcoma patient samples. By dissecting mechanisms of sarcoma development, normal tissue injury from radiation, and tumor response to radiation therapy alone and in combination with immunotherapy, I anticipate that our studies will not only reveal fundamental mechanisms of radiation and cancer biology but will also lead to improved treatment for sarcomas and other cancers.

PI_NAMEs: KIRSCH, DAVID GUY (contact)

PROGRAM_OFFICER_NAME: BUCHSBAUM, JEFFREY

PROJECT_TERMS: acute toxicity;Advanced Malignant Neoplasm;Area;Biological Models;Biology;Cancer Biology;Cancer Patient;cancer therapy;Cell Line;checkpoint inhibition;Chimeric Proteins;Chromatin Remodeling Factor;Clinical Trials;CRISPR/Cas technology;design;Development;DNA Damage;Funding;Future;Genetically Engineered Mouse;Goals;Human;Immune;Immunotherapy;improved;improved outcome;in vitro Model;innovation;Knowledge;Late Effects;Maintenance;Malignant Neoplasms;Mediating;Modeling;Mus;Mutation;Myxoid Liposarcoma;Neoplasm Metastasis;Normal tissue morphology;novel;palliating symptoms;Patient-Focused Outcomes;Patients;Phosphorylation;prion-like;programs;Quality of life;Radiation;radiation carcinogenesis;radiation effect;Radiation Injuries;Radiation Oncologist;radiation response;Radiation therapy;Radiation Tolerance;Radiobiology;randomized, clinical trials;Research;Resistance;response;Sampling;Sarcoma;success;Testing;Therapeutic;tumor;tumor progression;Work

PROJECT_TITLE: Advancing Cancer Therapy through Groundbreaking Research in Radiation Biology


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: HOUSTON

ORG_NAME: METHODIST HOSPITAL RESEARCH INSTITUTE

ORG_STATE: TX

PHR: OVERALL PROJECT NARRATIVE Bladder cancer is the second most common urologic malignancy; yet, remained a significantly underfunded and understudied cancer type. Major clinical gaps in early bladder lesions [defined as non-muscle invasive bladder cancer (NMIBC)] include 1) lack of mechanistic insights defining NMIBC progression, and 2) lack of platform for risk stratifying NMIBC that recur but never progress, from those that progresses into MIBC and consequently demonstrate poor prognosis. The knowledge gained by our Center will inform future NIMBC management through 1) the development of novel urinary profiling strategies that could risk stratify aggressive NMIBC (Project 1-3); 2) the identification of targets for future precision intervention, either by enhancing/sustaining the tumor- restraining mechanisms (Project 1) and/or inhibiting the tumor-promoting mechanisms (Project 2).

PI_NAMEs: CHAN, KEITH SYSON  (contact);THEODORESCU, DAN

PROGRAM_OFFICER_NAME: KAI, MIHOKO

PROJECT_TERMS: Address;Affect;anti-cancer research;Antitumor Response;B-Lymphocytes;Basic Science;Benchmarking;Bioinformatics;Biological;Biological Markers;Biology;biomarker development;biomarker validation;Bladder;Cancer Biology;Cancer Patient;cancer recurrence;cancer type;candidate marker;carcinogenesis;Carcinogens;Cell Communication;cell type;Cells;Clinical;clinical practice;cohort;Coin;Communication;Communities;Data;Development;Diagnosis;Disease;driving force;Ensure;fibroblast-activating factor;Fibroblasts;Fingerprint;functional genomics;Funding;Future;Genes;Genomics;Goals;Human;Immune;Immunoassay;Individual;induced pluripotent stem cell;innovation;insight;Knowledge;knowledge integration;Lesion;Lymphoid Tissue;lymphotoxin beta receptor;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Maps;Mediating;Medical center;Modeling;mouse model;Multi-Institutional Clinical Trial;multidisciplinary;Muscle;neoplastic cell;non-muscle invasive bladder cancer;novel;Organ;Outcome;Paracrine Communication;Pathologic;Pattern;personalized intervention;Persons;Pilot Projects;Population;Primary Lesion;progenitor;Prognosis;programs;Property;prospective;Protein Secretion;Proteins;Proteomics;recombinase;recruit;Recurrence;Reporting;Research;Research Personnel;Resource Sharing;restraint;risk stratification;Role;Sampling;Side;single cell technology;single-cell RNA sequencing;success;T-Lymphocyte;tertiary lymphoid organ;transcriptomics;translational oncology;tumor;tumor growth;tumor progression;Tumor Promotion;understudied cancer;urinary;Urine;urologic;Urothelial Cell;Validation;Yin

PROJECT_TITLE: The stromal microenvironment as a co-organizer of bladder carcinogenesis  and progression


NIH_SPENDING_CATS: Cancer;Urologic Diseases

PI_NAMEs: CHAN, KEITH SYSON  (contact)

PROJECT_TERMS: Animals;Annual Reports;Area;Bioinformatics;Biometry;Bladder;Budgets;carcinogenesis;Collaborations;Communication;Communities;data management;Data Reporting;Ensure;Ethics;Evaluation;Experimental Designs;Feedback;Funding;General Population;Goals;high standard;improved;Individual;Infrastructure;Institution;Institutional Review Boards;Leadership;Malignant neoplasm of urinary bladder;Manuscripts;Medical center;meetings;multidisciplinary;Organ;Participant;patient advocacy group;Patients;Press Releases;Program Evaluation;Program Research Project Grants;Program Reviews;programs;Proteomics;Protocols documentation;Publications;Recommendation;Research;Research Personnel;Resource Sharing;Rotation;Services;synergism;Training;transcriptomics;Update;Work

PROJECT_TITLE: Administrative Core


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: ANN ARBOR

ORG_NAME: VETERANS HEALTH ADMINISTRATION

ORG_STATE: MI

PHR: The large number of Veterans with chronic low back pain who seek care at the Veterans Health Administration (VHA) are being asked to try non-drug options before higher-risk pain medications. Although there are effective non-drug options, including complementary and integrative health treatments, they can be challenging to access. This research will examine self -administered acupressure for pain relief for Veterans with chronic low back pain. It is a low-risk treatment shown to be effective for people with other pain conditions and can be done virtually anywhere with an app for guidance. This study will engage Veterans an d other stakeholders to help [determine strategies to best integrate acupressure into VHA if effective and offer the app through a Whole Health class at three VA sites and virtually]. This study will contribute to evidence for self-administered acupressure as a treatment for chronic low back pain and begin to examine how it can be sustained system- wide using established resources.

PI_NAMEs: KREIN, SARAH  (contact)

PROJECT_TERMS: active duty;Acupressure;Acupuncture Therapy;Address;Adherence;Age;Ambulatory Care Facilities;Analgesics;arm;Back Pain;biopsychosocial;care seeking;Caring;Cessation of life;Characteristics;Chinese Traditional Medicine;chronic back pain;Chronic low back pain;chronic pain;chronic pain management;chronic painful condition;Clinical effectiveness;Clinical Practice Guideline;common treatment;Communities;Complementary Health;Complex;Control Groups;cost;Country;design;disability;Education;Educational Curriculum;Educational process of instructing;Effectiveness;effectiveness evaluation;effectiveness/implementation design;effectiveness/implementation study;efficacy study;ethnic minority population;Evaluation;evidence base;Evidence based intervention;experience;Fatigue;Female;future implementation;Geography;Goals;Health;Health Services Accessibility;Health system;Healthcare;high risk;Home;implementation barriers;implementation determinants;implementation efforts;implementation facilitators;improved;Infrastructure;innovation;Integrative Medicine;interest;Intervention;intervention effect;Interview;Knowledge;knowledge base;Low Back Pain;Measures;Medical;Medical center;member;Mental Depression;Methodology;Methods;Michigan;multimodality;non-drug;non-opioid analgesic;Nonpharmacologic Therapy;Opioid;opioid epidemic;opioid user;Outcome;Overdose;Pain;Pain interference;Pain management;pain outcome;pain reduction;pain relief;pain symptom;Participant;Patients;Persons;Pharmaceutical Preparations;Population;post intervention;preference;Primary Care;Process;Protocols documentation;Provider;racial minority population;Randomized;Reach, Effectiveness, Adoption, Implementation, and Maintenance;recruit;Replicating Effective Programs;Reporting;Research;Resources;response;Risk;Self Administration;Self Management;sex;side effect;Site;Sleep;Sleep disturbances;sleep quality;Statutes and Laws;Structure;symptom treatment;symptomatic improvement;System;systematic review;Techniques;Testing;Time;Training;treatment risk;trial planning;uptake;Veterans;Veterans Health Administration;virtual;Waiting Lists;whole health;Work

PROJECT_TITLE: Self-Administered Acupressure for Veterans with Chronic Back Pain: A Multisite Evaluation of Effectiveness and Implementation

STUDY_SECTION_NAME: HSR-1 Health Care and Clinical Management[HSR1]


PROJECT_TERMS: Address;Agonist;Antitumor Response;B-Cell Neoplasm;B-Lymphocytes;Benchmarking;Biological;Biological Markers;biomarker evaluation;Bladder;Cancer Model;Cancer Patient;cancer subtypes;candidate marker;carcinogenesis;Carcinogens;Cells;chemokine;Chronic;Clinical;clinically relevant;clinically significant;cohort;CXCR4 gene;Data;Disease;Fibroblasts;follow-up;Frequencies;Future;Helper-Inducer T-Lymphocyte;Homing;Human;Image;Immune;in vivo;Inflammation;innovation;insight;Investigation;Knock-out;lead candidate;Lesion;Ligands;lymph nodes;Lymphoid Tissue;lymphotoxin beta;lymphotoxin beta receptor;Malignant neoplasm of urinary bladder;Mediating;Modeling;Molecular;mouse model;Mus;Muscle;Myelogenous;neutralizing antibody;neutrophil;non-muscle invasive bladder cancer;novel;Organogenesis;Patients;personalized intervention;Phenotype;Pilot Projects;Population;pre-clinical;Pre-Clinical Model;preclinical study;Process;Production;Prognosis;Progression-Free Survivals;Protein Secretion;Publishing;Receptor Activation;Receptor Signaling;recruit;Regulation;Research;restraint;risk stratification;Role;S100A8 gene;Signal Transduction;single-cell RNA sequencing;Stromal Cell-Derived Factor 1;Study models;success;T-Lymphocyte;tertiary lymphoid organ;Tissues;tool;tumor;Tumor Immunity;Tumor Necrosis Factor-Beta;Tumor Promotion;tumorigenesis;Urothelium

PROJECT_TITLE: Project 1


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Urologic Diseases

PI_NAMEs: THEODORESCU, DAN  (contact)

PROJECT_TERMS: 3-Dimensional;Address;Appearance;Automobile Driving;Basal Cell;Benchmarking;Biological Assay;Bladder;Bladder Tissue;C3 gene;cancer cell;Cancer cell line;Cancer Patient;carcinogenesis;Cell Communication;Cell surface;Cells;Characteristics;Clinical;Coculture Techniques;Communication;Data;data fusion;Defect;Detection;Development;Disease;Epithelium;Evolution;Exhibits;fibroblast-activating factor;Fibroblasts;follow-up;functional genomics;Gene Expression Profile;Genes;genetic signature;Genomic Library;Growth;Heritability;Human;Immunocompetent;Immunocompromised Host;Implant;In Vitro;in vivo;indexing;induced pluripotent stem cell;innovation;intravesical;Invaded;Knockout Mice;Lesion;Ligands;Literature;Malignant - descriptor;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Maps;Modeling;mouse model;Mus;Muscle;muscle invasive bladder cancer;Names;neoplastic cell;non-muscle invasive bladder cancer;Normal Cell;novel;novel marker;Outcome;overexpression;Patients;personalized intervention;Phenotype;Population;population based;Portraits;Prevalence;prevent;Prevention;Process;progression marker;Property;protein protein interaction;Proteomics;Protocols documentation;receptor;Research;Risk;risk stratification;RNA;Role;Semaphorin-3A;single nucleus RNA-sequencing;spatiotemporal;stem cells;subcutaneous;success;Testing;The Cancer Genome Atlas;Time;transcriptomics;translational impact;tumor;Tumor Cell Invasion;tumor growth;tumor microenvironment;tumor progression;Urothelium;Work;Xenograft Model

PROJECT_TITLE: Project 2


PI_NAMEs: FURUYA, HIDEKI  (contact)

PROJECT_TERMS: Address;Affect;Benchmarking;Biological Assay;Biological Markers;Biology;biomarker panel;Bladder;Cancer Death Rates;Cancer Model;cancer recurrence;candidate marker;carcinogenesis;Carcinogens;case control;Cells;Cessation of life;Classification;Clinical;clinical diagnosis;clinically relevant;cohort;combat;Data;Derivation procedure;Development;Diagnostic;Disease;Early Diagnosis;Educational workshop;Epithelium;Fibroblasts;Fingerprint;Goals;high risk;IL8 gene;Image;Immune;Immunoassay;innovation;insight;Lesion;Longitudinal Studies;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Methods;MMP9 gene;Modality;Modeling;mortality;mouse model;Mus;Muscle;non-muscle invasive bladder cancer;novel;novel marker;overexpression;Pathologic;Patient Care;Persons;Phase;Plasminogen Activator Inhibitor 1;Prognosis;prospective;Prospective Studies;Protein Fingerprints;restraint;risk stratification;Role;Sampling;single-cell RNA sequencing;Stromal Cells;stromelysin 2;success;Survival Rate;Testing;Tissues;tumor;tumor microenvironment;tumor progression;Tumor Promotion;Urine;urologic;Urothelium;validation studies;VEGFA gene

PROJECT_TITLE: Project 3


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Urologic Diseases

PI_NAMEs: LEWIS, MICHAEL STANLEY (contact)


ED_INST_TYPE: SCHOOLS OF MEDICINE

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Hematology;Infectious Diseases;Lung;Neurosciences;Pneumonia;Pneumonia and Influenza;Sepsis

ORG_CITY: SAINT LOUIS

ORG_DEPT: SURGERY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE  The current biological evidence suggests that light profoundly influences the physiologic capacity with which an organism responds to stress; yet, the ramifications of light on human health and disease remain to be convincingly defined. Our published data highlight that a short exposure to bright blue light can be used to favorably modify the biology and outcome of sepsis. We will now examine the biological and circadian mechanisms underlying our observation that acute exposure to high illuminance blue light during sepsis enhances immune competence and control of the infection, attenuates inflammation, and protects against organ injury. We will then confirm the biological relevance of these mechanisms and blue light therapy in patients with pneumonia. Our characterization of the biological mechanisms through which blue light beneficially alters the cellular response to sepsis provides conceptual and translational innovation to develop a potential therapeutic for the treatment of many diseases.

PI_NAMEs: ROSENGART, MATTHEW RANDALL (contact)

PROGRAM_OFFICER_NAME: ZHAO, XIAOLI

PROJECT_TERMS: Actins;Acute;adaptive immunity;Agonist;Antibody Formation;Antigen Presentation;Attention;Attenuated;Autonomic nervous system;B cell differentiation;B-Cell Development;B-Lymphocytes;Bacteria;Biological;Biology;blue light therapy;Bone Marrow;Cell Respiration;Cells;Cellular biology;Central Nervous System;cholinergic;circadian;circadian biology;circadian pacemaker;Clock protein;Complex;Cues;Data;Development;Dimensions;Disease;Evolution;Exposure to;Eye;fitness;FRAP1 gene;Gene Cluster;Genes;Health;Histocompatibility Antigens Class II;Hour;Human;hypothalamic-pituitary-adrenal axis;Immune;immune function;Immune response;Immune system;Immunity;Immunocompetence;Immunoglobulins;improved outcome;In Vitro;in vivo;Individual;Infection;Infection Control;Inflammation;Inflammatory;innovation;Interferon Type I;Intra-abdominal;Invaded;Ischemia;Kidney;Klebsiella pneumoniae;Leukocytes;Light;Liver;Mammalian Cell;Mediating;Metabolic;microbial;Mitochondria;Modeling;Molecular;monocyte;Mononuclear;mouse model;Mus;Natural Immunity;neurophysiology;Ontology;Optics;Organ;organ injury;Organism;Outcome;pathogen;Pathway interactions;Patients;Peripheral;Phagocytes;Phenotype;Physiological;Physiology;PIK3CG gene;Pineal gland;Pneumonia;Population;Process;Production;programs;Proteins;Proto-Oncogene Proteins c-akt;Publishing;recruit;Reperfusion Therapy;Research;response;rev Protein;Role;Sepsis;septic;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Spleen;Splenectomy;Stress;suprachiasmatic nucleus;System;systemic inflammatory response;Therapeutic;tissue injury;Tissues;Travel;Work

PROJECT_TITLE: The role of circadian clock proteins in innate and adaptive immunity

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Pediatric

ORG_CITY: LEICESTER

ORG_COUNTRY: UNITED KINGDOM

ORG_FIPS: UK

ORG_NAME: UNIVERSITY OF LEICESTER

ORG_ZIPCODE: LE7 9HR

PHR: Project Narrative Repeated hypoglycemia can blunt the usual protective physiological symptomatic and hormonal responses to hypoglycemia, leading to impaired awareness of hypoglycemia that affects up to a third of people living with type 1 diabetes and puts them at increased risk of the morbidity and mortality associated with severe hypoglycemia. Advances in patient education and technology, including continuous glucose monitoring systems and hybrid closed loops can reduce the exposure to hypoglycemia, but have demonstrated limited ability to restore impaired protective counter regulatory and symptom responses to hypoglycemia. The overall objective of this project is to provide a better understanding of demographic, glycaemic and behavioural factors that contribute to restoration of awareness of hypoglycemia, including normalisation of symptomatic and hormonal responses to hypoglycemia, and develop better tools for allowing us to assess awareness and changes in awareness status.

PI_NAMEs: CHOUDHARY, PRATIK  (contact)

PROGRAM_OFFICER_NAME: ARREAZA-RUBIN, GUILLERMO

PROJECT_TERMS: Address;Affect;Age;Awareness;Behavioral;Belief;Biochemical;Caring;Categories;Clinical;Closure by clamp;Cognition;Continuous Glucose Monitor;Defect;Demographic Factors;Diabetes Mellitus;Diagnostic;Education;Electronics;Epinephrine;Exposure to;Glucose;Gold;Heterogeneity;Hormonal;Hybrids;Hypoglycemia;Impairment;improved;Individual;Insulin;Insulin-Dependent Diabetes Mellitus;Intervention;Measurement;Measures;Morbidity - disease rate;mortality;Names;novel;outcome prediction;Outcome Study;Participant;Patient Education;Patient Self-Report;Persons;Physiological;Predictive Factor;programs;psychoeducation;Questionnaires;Research Design;response;restoration;Review Literature;Risk;Screening procedure;Symptoms;System;Technology;Thinking;Time;tool;Variant

PROJECT_TITLE: Elucidating the heterogeneity of impaired awareness of hypoglycaemia in type 1 diabetes


ORG_CITY: BIRMINGHAM

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: The IRACDA-MERIT Program is designed to address the growing demand for future faculty who can conduct cutting-edge research and teach effectively. By providing outstanding postdoctoral scholars with formalized research instruction at the Host Institution and teaching instruction at the Partner Institutions, which serve undergraduates from underrepresented groups within the state of Alabama, the IRACDA-MERIT Program meets this need while positively impacting and promoting diversification of the future biomedical workforce.

PI_NAMEs: SCHNEIDER, DAVID ALAN (contact)

PROGRAM_OFFICER_NAME: NELSON, SHAKIRA M

PROJECT_TERMS: Alabama;Award;Behavioral Research;Biomedical Research;Collaborations;community college;course development;curriculum development;Educational process of instructing;Elements;experience;Faculty;Funding;Grant;improved;Institution;Instruction;Laboratories;Mentors;Mission;Occupations;Postdoctoral Fellow;Preparation;Productivity;programs;Radial;recruit;Research;research and development;Research Ethics;Research Personnel;Research Project Grants;Resources;Schools;Science;Series;skill acquisition;summer research;Time;Training;undergraduate student;Underrepresented Populations;Universities;Writing

PROJECT_TITLE: Mentored Experiences in Research, Instruction and Teaching (MERIT) Program

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - C[TWD-C]


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Chronic Pain;Clinical Research;Dental, Oral, and Craniofacial Disease;Disability Research;Neurosciences;Pain Research;Precision Medicine;Prevention;Temporomandibular Muscle/Joint Disorder (TMJD)

ORG_CITY: BALTIMORE

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: Narrative Because of the difficulty in treating chronic pain, development of brain signal predictive biomarkers is of growing interest. Here we propose to develop a predictive biomarker signature of pain severity and duration using two commonly available techniques – electroencephalogram (EEG) and transcranial magnetic stimulation (TMS) – and perform initial clinical validation in first onset temporomandibular disorder (TMD). The biomarker could have utility in identifying patients at high risk of transitioning from acute to chronic pain, and has additional potential for clinical application in the treatment and prevention of chronic pain.

PI_NAMEs: DA SILVA, JOYCE TEIXEIRA (contact);SCHABRUN, SIOBHAN ;SEMINOWICZ, DAVID

PROGRAM_OFFICER_NAME: ARUDCHANDRAN, RAMACHANDRAN NMN

PROJECT_TERMS: Acute;Affective;Automation;Biological Markers;biomarker development;biomarker signature;biomarker validation;Brain;candidate marker;chronic musculoskeletal pain;chronic pain;chronic pain management;Clinical;clinical application;cost;Data;Detection;Development;diaries;disability;Disabling condition;Disease Outcome;Early Intervention;Economic Burden;Economics;effective therapy;Electroencephalography;experience;Frequencies;Future;Health;high risk;high risk population;Human;human model;Individual;interest;Intramuscular Injections;Investigation;Laboratories;Malignant Neoplasms;Measures;Methods;Modeling;Musculoskeletal Pain;Nerve Growth Factors;neuroimaging;Neurosciences;non-opioid analgesic;novel;Opioid;Pain;pain chronification;Pain Measurement;pain model;pain sensitivity;Participant;Patients;performance tests;Persistent pain;Phase;predictive marker;predictive signature;Predisposition;Prevalence;Prevention;prospective;Psychosocial Factor;Recovery;Recurrence;resilience;Rest;Rheumatism;Risk;Severities;Signal Transduction;Sleep;social;Specificity;Standardization;Stress;Techniques;Temporomandibular Joint Disorders;temporomandibular pain;Test Result;Testing;Time;Transcranial magnetic stimulation;Validation;validation studies;Vulnerable Populations;Work

PROJECT_TITLE: Validation of a novel cortical biomarker signature for pain


NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Chronic Pain;Clinical Research;Fibromyalgia;Lupus;Neurosciences;Opioids;Pain Research;Precision Medicine

ORG_CITY: AUSTIN

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

PHR: Fibromyalgia (FM) is a chronic non-malignant pain disorder that results from abnormalities in central pain processing and accounts for a major percentage of opioid prescriptions thus contributing to the opioid epidemic. An objective marker identifying FM could confirm the presence of disease and mitigate opiate prescribing for this condition that does not respond to them. We will evaluate the potential of vibrational (infrared and Raman) spectroscopy technology and supervised pattern recognition analysis (“chemometrics”) coupled with complementary metabolomics analyses by LC-MS/MS to differentiate FM subjects from other conditions and identify potential pharmacologic targets of interest for this condition that suffers from a lack of reliable therapeutic options.

PI_NAMEs: HACKSHAW, KEVIN VICTOR (contact);RODRIGUEZ-SAONA, LUIS E

PROJECT_TERMS: accurate diagnosis;addiction;Adult;Adverse event;Affect;Age;Alternative Therapies;American;Assessment tool;Biological;Biological Assay;Biological Markers;biomarker identification;Blood;Calibration;central pain;Cessation of life;Chronic;Chronic low back pain;chronic pain;chronic pain patient;chronic widespread pain;Clinical;Clinical Medicine;cohort;college;cost;Cost Analysis;Coupled;Data Set;Degenerative polyarthritis;Development;Diagnosis;Diagnostic;Diagnostic tests;disability;Disease;Economic Burden;Etiology;evidence base;Exposure to;Fibromyalgia;fibromyalgia patients;Fingerprint;Flare;follow-up;Goals;Guidelines;Health Care Costs;health related quality of life;Healthcare;Healthcare Systems;Individual;innovation;interest;Interstitial Cystitis;Intervention;Knowledge;Life;Lupus;Medical;Medicine;metabolic profile;metabolomics;Methodology;Methods;Modeling;Monitor;Nervous System Disorder;Neuropathy;Non-Malignant;Opioid;opioid epidemic;opioid use;Outcome;Pain;Pain Disorder;pain processing;Pathogenesis;Patients;Pattern;Pattern Recognition;pharmacologic;Phase;Population;Populations at Risk;prescription opioid;Productivity;Prognosis;Recommendation;Resources;Rheumatoid Arthritis;rheumatologist;Rheumatology;Role;Sampling;screening;Severities;Severity of illness;Spectrum Analysis;Spottings;success;Symptoms;Syndrome;Systemic Lupus Erythematosus;Techniques;Technology;Testing;Therapeutic;tool;United States;Visit;Woman;Work

PROJECT_TITLE: Objective tests utilizing Vibrational Spectroscopy for Diagnosis and Severity of Fibromyalgia and Related Pain Syndromes

STUDY_SECTION: NSD

STUDY_SECTION_NAME: Neurological Sciences and Disorders A Study Section[NSD-A]


ORG_CITY: Decatur

ORG_STATE: GA

PHR: As many as 75% of people with Parkinson’s disease (PD), including many veterans, complain that their PD medications do not work well for them all the time, resulting in "OFF-time". We want to look at how different types of exercise might improve veteran satisfaction with their PD medications. Our data show that patients with PD who did partnered dance aerobic exercise (PDAE) reported less OFF-time. These patients also improved in spatial cognition, endurance and mental quality of life. Although the PD community recognizes exercise as helpful, no one has shown that it actually slows down neurodegeneration in the brains of people with PD. In veterans with PD, we will determine if PDAE reduces OFF-time, and improves cognition. Also, using cutting-edge, new and robust imaging techniques, we will determine if PDAE or another type of aerobic exercise slows neurodegeneration in PD.

PI_NAMEs: HACKNEY, MADELEINE EVE (contact)

PROJECT_TERMS: active method;Address;Aerobic Exercise;Behavioral;Biological Assay;Biological Markers;Brain;Brain region;Clinical;Clinical Sciences;Cognition;Cognitive;Cognitive deficits;cognitive function;cognitive task;Communities;comparative efficacy;Dancing;Data;Diagnosis;Disease;drug efficacy;efficacy study;Exercise;Exercise Therapy;exercise training;experience;follow-up;Functional Magnetic Resonance Imaging;Healthcare;Hour;Human;Image;Imaging Techniques;Impaired cognition;improved;innovation;Intervention;Iron;Magnetic Resonance Imaging;Maintenance;Measures;Medical;mental training;mode of exercise;Modeling;Motor;motor impairment;motor symptom;Movement Disorder Society Unified Parkinson's Disease Rating Scale;Nerve Degeneration;neural;Neurobehavioral Manifestations;neuromelanin;neurophysiology;neuroprotection;Newly Diagnosed;Nonpharmacologic Therapy;novel;Operative Surgical Procedures;Outcome;Outcome Measure;Parkinson Disease;Parkinsonian Disorders;pars compacta;Participant;Pathway interactions;patient oriented;Patient Self-Report;Patients;Persons;Pharmaceutical Preparations;Phase;Physical activity;Physiological;post intervention;primary outcome;Process;Psyche structure;psychosocial;Psychosocial Factor;Quality of life;Randomized;Randomized, Controlled Trials;Rehabilitation therapy;Reporting;Sampling;satisfaction;Schedule;social;social attention;Social support;Standardization;Substantia nigra structure;Testing;Time;tool;Touch sensation;Training;Veterans;Walking

PROJECT_TITLE: Partnered Dance Aerobic Exercise as a neuroprotective, motor and cognitive intervention in Parkinson's disease

STUDY_SECTION_NAME: Musculoskeletal Health & Function[RRD2]


ORG_CITY: LOS ANGELES

ORG_NAME: VA GREATER LOS ANGELES HEALTHCARE SYSTEM

ORG_STATE: CA

PHR: Inner ear hypofunction is characterized by subtle compromise without that escape detection by traditional measures of cochlear and vestibular function. They may be associated with loss of synaptic components within sensory structures, but occur without overt loss of sensory cells or neurons. These synaptopathies can be induced by mild ototoxicity resulting in the hypofunction and not complete loss of function. US service personnel and Veterans are exposed to various conditions representing risk factors for vestibular hypofunction, including jet fuel vapors and treatments with known ototoxic agents including aminoglycoside antibiotics. There is recent evidence indicating that it may be associated with dizziness secondary to traumatic brain injury. The proposed research plan represents a comprehensive investigation of peripheral vestibular hypofunction in an animal model through which direct cellular, electrophysiologic, and behavioral correlates will be obtained. In particular, we will test whether vestibular hypofunction is associated with loss of synaptic structures as has been found in the cochlea. Through this research will emerge a novel behavioral test of vestibular function that can be readily translated to the clinical vestibular evaluation, and be implemented as a rehabilitative tool. Hence, the outcomes of this investigation will serve as a foundation for diagnosis and therapy to improve alleviate functional decline.

PI_NAMEs: HOFFMAN, LARRY F (contact)

PROJECT_TERMS: Acoustic Trauma;Address;Affect;Afferent Neurons;Afferent Pathways;age related;Aging;Aminoglycoside Antibiotics;Aminoglycosides;Animal Model;Animals;Architecture;Attenuated;Behavior;behavior test;Behavioral;Bilateral;Cells;Characteristics;Clinical;Cochlea;cochlear synaptopathy;Code;cohort;Confocal Microscopy;Country;Crista ampullaris;Data;density;Detection;Development;Diagnosis;Diagnostic;Dizziness;Dose;effective therapy;efficacy testing;Electrophysiology (science);Epithelium;Etiology;Evaluation;Exhibits;Experimental Designs;Exposure to;Foundations;functional decline;Functional disorder;Future;Gentamicins;Hair Cells;Head;Head Movements;Human Resources;Immunohistochemistry;improved;Incubated;Investigation;Ipsilateral;kinematics;Knowledge;Label;Labyrinth;Liquid substance;Locomotion;loss of function;Measures;Morphology;multimodality;Mus;Neurobiology;Neurons;Noise;novel;ototoxicity;Outcome;Outcome Measure;Penetrance;Performance;Peripheral;Physiological;Physiology;Population;postsynaptic;rehabilitation research;rehabilitation strategy;Rehabilitation therapy;Research;research and development;response;Response to stimulus physiology;Rewards;ribbon synapse;Risk;Risk Factors;Running;Secondary to;sedentary;Sensory;Services;Signal Transduction;Stimulus;Structure;Synapses;Testing;Time;tool;Training;Translating;transmission process;Traumatic Brain Injury;treadmill;Treadmill Tests;ultra high resolution;Uncertainty;vapor;Vestibular function;Vestibular Function Tests;Vestibular Hair Cells;vestibular system;vestibulo-ocular reflex;Veterans

PROJECT_TITLE: Neurobiology and Behavioral Consequences of Peripheral Vestibular Synaptopathy andRehabilitation

STUDY_SECTION_NAME: Sensory Systems & Communication Disorders[RRD3]


FUNDING_MECHANISM: OTHERS

ORG_CITY: BOSTON

ORG_NAME: VA BOSTON HEALTH CARE SYSTEM

ORG_STATE: MA

PHR: Heart disease and diabetes are leading causes of death and disability in the US, especially among Veterans. Posttraumatic stress disorder (PTSD) is a disabling condition that also affects many Veterans. New research suggests that PTSD further increases the risk of developing heart disease and diabetes. What causes this increased risk is unknown. However, individuals with PTSD are often less physically active and make more unhealthy dietary choices than individuals without PTSD. Maintaining a physically active lifestyle, staying physically fit, and eating a healthy diet may be important for reducing the PTSD related risk for heart disease, diabetes and disability. The proposed research seeks to assess how important these lifestyle factors are for reducing the risk of heart disease, diabetes and disability in Veterans with and without PTSD. A better understanding of these lifestyle factors and cardiometabolic health in Veterans will help to clarify how lifestyle interventions can best be applied to the prevention and treatment of long-term disability in Veterans.

PI_NAMEs: WHITWORTH, JAMES W (contact)

PROJECT_TERMS: Accelerometer;active lifestyle;Address;Affect;Blood Glucose;blood glucose regulation;blood lipid;Blood Pressure;blood pressure reduction;Body mass index;Boston;Cardiometabolic Disease;cardiometabolic risk;cardiometabolism;cardiorespiratory fitness;Cardiovascular Diseases;Cardiovascular system;career;Caring;Cause of Death;Center for Translational Science Activities;Clinical;cohort;Collection;Data;Development;Diabetes Mellitus;Diagnosis;Diet;dietary;Dietary intake;disability;disability risk;Disabling condition;Dyslipidemias;Eating;Exercise;exercise rehabilitation;Family;Future;Glucose;good diet;Health;Healthcare Systems;heart disease risk;Heart Diseases;Hypertension;improved;Individual;K-Series Research Career Programs;Lead;Life Style;lifestyle factors;lifestyle intervention;Link;Lipids;Long term disability;Longitudinal cohort study;Longitudinal Studies;Measurement;Measures;Mediating;Mentorship;Metabolic;modifiable lifestyle factors;mortality;Non-Insulin-Dependent Diabetes Mellitus;Nonpharmacologic Therapy;novel;Obesity;Oxygen;Participant;Pathway interactions;Patient Self-Report;Physical activity;physical inactivity;post 9/11;post-trauma exposure;Post-Traumatic Stress Disorders;Premature Mortality;Prevention;Provider;Rehabilitation therapy;Research;Risk;Risk Factors;Risk Reduction;sedentary;Series;Severities;Skeletal Muscle;stress disorder;Symptoms;Therapeutic Effect;Time;Training;Unhealthy Diet;United States;Veterans

PROJECT_TITLE: Impact of Lifestyle on Cardiovascular and Metabolic Risk Factors in Trauma Exposed Post-9/11 Veterans

STUDY_SECTION_NAME: Career Development Program - Panel II[RRD9]


PHR: Chronic Obstructive Pulmonary Disease (COPD) is prevalent and debilitating chronic disease in Veterans. COPD is highly co-morbid with depression and anxiety conferring greater morbidity and mortality risk. Physical activity is a modifiable behavior that can improve COPD outcomes. However, to date, interventions targeting physical activity have not addressed the high comorbidity between COPD and depression and/or anxiety symptoms (“emotional distress”) despite emotional distress predicting poorer response to physical activity interventions. This CDA-2 proposal will develop and test the feasibility and limited-efficacy of an integrative physical activity and mental health intervention for Veterans with COPD, emotional distress, and low physical activity. The intervention will be delivered via VA Video Connect enabling access to care among Veterans with substantial barriers to hospital-based outpatient care.

PI_NAMEs: BAMONTI, PATRICIA  (contact)

PROJECT_TERMS: Aging;Ambulatory Care;Anxiety;anxiety symptoms;Area;Behavior;behavior change;Boston;burden of illness;Bypass;care systems;career development;Caring;Cause of Death;Cessation of life;Chronic Disease;Chronic Obstructive Pulmonary Disease;clinically significant;Cognition;Cognitive Therapy;comorbid depression;comorbidity;Complex;COVID-19 pandemic;Data;depressive symptoms;design;Development;Diabetes Mellitus;Diagnostic;disability;Disease;Disease Outcome;Distress;Dyspnea;efficacy testing;Emotional;emotional distress;Emotions;Enrollment;Exercise;exercise intervention;experience;Fatigue;feasibility testing;Future;Goals;Health Services Accessibility;Health Technology;Heart failure;Home;Home environment;Hospitalization;Hospitals;improved;innovation;Intervention;Interview;Label;Language;Life;Literature;Lived experience;Longitudinal Studies;Maintenance;Manuals;Measures;Mental Depression;Mental Health;Methodology;Methods;modifiable behavior;Modification;Monitor;Morbidity - disease rate;mortality risk;multidisciplinary;Outcome;participant retention;patient oriented;Patient Self-Report;Patients;Pattern;pedometer;Periodicity;Persons;Physical activity;Physical Function;physically handicapped;primary outcome;Problem Solving;Process;Protocols documentation;psychoeducation;psychologic;pulmonary rehabilitation;Quality of life;Randomized;recruit;rehabilitation research;Rehabilitation therapy;Reporting;Research;research and development;Research Personnel;response;Risk;Running;SARS-CoV-2 infection;Science;screening;secondary outcome;Self Management;Services;severe COVID-19;Social Interaction;standard care;statistics;Strategic Planning;symptomatology;telehealth;Testing;Therapeutic Intervention;Thinking;Training;Training and Education;treatment adherence;treatment as usual;treatment guidelines;Treatment Protocols;treatment response;Veterans

PROJECT_TITLE: The Development of an Integrated Physical Activity and Mental Health Intervention for Veterans with COPD, Emotion Distress, and Low Physical Activity


ORG_CITY: MATHER

ORG_NAME: VA NORTHERN CALIFORNIA HEALTH CARE SYS

PHR: As Veterans transition to community, success in achieving school, work and other goals are top priorities. However, difficulties with concentration, memory, irritability and other symptoms of cognitive-emotional dysregulation can ‘derail’ the life paths of Veterans with traumatic brain injury (TBI), post-traumatic stress disorder (PTSD), and related issues. Many Veterans are interested in approaches to building their personal strengths – approaches that help them help themselves. Barriers to care leave gaps for many Veterans. Our overall mission is to help Veterans build strengths for regulating attention, keeping key information in mind, staying on track, and following through despite challenges in order accomplish goals. This project will provide access to learning experiences to improve brain functioning via tele-rehabilitation. The project will inform Veteran-centered care that Veterans can access at home, in school, and in other settings.

PI_NAMEs: CHEN, ANTHONY  (contact)

PROJECT_TERMS: Active Learning;Address;Advanced Development;Age;Attention;barrier to care;Brain;Caring;Clinical;Cognitive;Collaborations;Communities;Complex;Data;design;digital applications;distraction;Education;Educational Intervention;emotion dysregulation;Enrollment;experience;falls;Feedback;follow-up;Foundations;Fright;functional improvement;Goals;Home;improved;indexing;information processing;innovation;interest;Intervention;Knowledge;Label;Learning;Left;Life;Location;Measurement;Measures;Memory;Methods;Mission;Modality;Neurobehavioral Manifestations;Neurocognitive;neurocognitive test;neurological rehabilitation;Nonpharmacologic Therapy;novel;online resource;Participant;Pathologic;Pathway interactions;Performance;post 9/11;Post-Traumatic Stress Disorders;preference;Procedures;programs;Protocols documentation;Randomized;Recording of previous events;Regulation;remote grading;Research;resilience;Running;Rural;Schools;Services;Short-Term Memory;skills;skills training;social stigma;Standardization;success;Technology;telerehabilitation;Testing;theories;therapy design;therapy development;Time;tool;Training;Translating;Traumatic Brain Injury;Veterans;Work

PROJECT_TITLE: Strengthening neuro-cognitive skills for success in school, work and beyond

STUDY_SECTION_NAME: Brain Health and Injury[RRD1]


ORG_CITY: Aurora

ORG_NAME: VA EASTERN COLORADO HEALTH CARE SYSTEM

ORG_STATE: CO

PHR: Multiple sclerosis (MS) is a common neurologic disease that is often more aggressive in men than women. As Veterans are mostly men, a higher proportion of Veterans with MS have more advanced disability (i.e., need assistance to walk or use a wheelchair) compared with non-Veterans with MS. Unfortunately, there currently is a lack of evidence to support exercise interventions in people with advanced disability due to MS. This project proposes to study a strength training program using blood flow restriction (BFR) in people with advanced disability due to MS. BFR uses a device that partially blocks blood flow to the exercising limb and causes a response in the muscle which can replicate the effects of high-intensity training using much lower intensities. This is ideal for people with MS who have advanced disability, as they often cannot tolerate higher intensity exercise due to severe weakness and fatigue. By studying BFR training in people with advanced disability due to MS, we hope to help improve strength, mobility, fatigue, and quality of life in Veterans with MS.

PI_NAMEs: MANAGO, MARK M (contact)

PROJECT_TERMS: Address;Affect;American;Ankle;Area;Award;Biological Markers;Blinded;Blood flow;Cell Proliferation;Chronic;Clinical;clinical center;clinical translation;Clinical Trials;Colorado;comparative effectiveness study;comparison control;Control Groups;Data;Devices;disability;Disability scale;Disease Progression;education research;efficacy evaluation;efficacy study;efficacy trial;Elderly;Exercise;exercise intensity;exercise intervention;experimental group;Fatigue;follow-up;functional group;Future;Goals;Health;Healthcare Systems;Hip region structure;Human Resources;Hypertrophy;Hypoxia;improved;improved mobility;Infrastructure;innovation;Intervention;Knee;Laboratories;Leadership;Limb structure;Measures;Mechanical Stress;Mechanics;men;Mentorship;Metabolism;Mobility decline;Morphology;Multiple Sclerosis;multiple sclerosis patient;Muscle;Muscle Fatigue;muscle form;muscle hypertrophy;Muscle satellite cell;muscle strength;Muscle Weakness;Musculoskeletal;Nervous System Disorder;novel;Outcome;Outcome Assessment;Participant;Patient Self-Report;Performance;Persons;Phase;Phase II Clinical Trials;physical conditioning;Population;post intervention;pressure;prevent;primary endpoint;primary outcome;Protein Biosynthesis;quadriceps muscle;Quality of life;Randomized;Randomized, Controlled Trials;rehabilitative care;Research;Research Personnel;Research Project Grants;Resistance;resistance exercise;Resources;response;Role;Safety;Science;screening;Single-Blind Study;skills;strength training;Symptoms;Thick;Time;Training;Training Programs;Ultrasonography;Veterans;Walking;Wheelchairs;Woman

PROJECT_TITLE: Low-Load Resistance Training with Blood Flow Restriction in People with Multiple Sclerosis and Advanced Disability: A Randomized Control Trial


ORG_CITY: CLEVELAND

ORG_NAME: LOUIS STOKES CLEVELAND VA MEDICAL CENTER

ORG_STATE: OH

PHR: Upper extremity limb loss disproportionately affects veterans compared to the general public. Loss of a limb robs the veteran of both function, and equally important, the sense of touch. The loss of touch comes with significant deficits in quality of life and connection to others. Significant investment over the past decade, however, has resulted in advanced prostheses that have significantly greater function than has ever been available and with a sense of touch such that the user feels the prosthesis as though it is their hand. These advances, however, have only been available in the lab. This project is the first randomized clinical trial to evaluate the if these new prostheses provide a better quality of life compared to prior devices. This project is the next critical step toward making advanced prostheses available as standard of care to veterans and to give them a prosthesis option that effectively replaces their lost hand.

PI_NAMEs: TYLER, DUSTIN J. (contact)

PROJECT_TERMS: Accelerometer;Adverse event;Affect;afferent nerve;Amputees;arm;Bluetooth;Case Series;Clinical;Country;Cross-Over Studies;Data;Data Set;Development;Devices;Electrodes;Emotional;Esthesia;experience;Feedback;Fingers;Freedom;functional improvement;functional outcomes;Funding;General Population;Hand;Hand functions;Home;Human;Implant;Implanted Electrodes;improved;improved outcome;indexing;Individual;Intramuscular;Intuition;Investments;Life;limb loss;Limb structure;Location;Longitudinal Studies;Marketing;Measures;Motion;Movement;Muscle;Nerve;new technology;Noise;Operative Surgical Procedures;Outcome;Peripheral;pilot trial;Population;Prosthesis;prosthesis control;prosthesis wearer;psychosocial outcome;Quality of life;Randomized;randomized, clinical trials;Readiness;Research;Research Project Grants;restoration;Ring Finger Domain;secondary analysis;sensor;Sensory;sensory feedback;Services;Signal Transduction;Skin;social deficits;Social outcome;Source;standard of care;Surveys;System;Technology;Testing;Thumb structure;Touch sensation;Training;treatment comparison;trial comparing;Upper Extremity;Veterans;Wrist

PROJECT_TITLE: Peripheral Interfaces in Amputees for Sensorimotor Integration

STUDY_SECTION_NAME: Rehabilitation Engineering & Prosthetics/Orthotics [RRD5]


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Patient Safety

ORG_CITY: HERSHEY

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: PENNSYLVANIA STATE UNIV HERSHEY MED CTR

ORG_STATE: PA

PHR: PROJECT NARRATIVE Individuals with Type 1 Diabetes (T1D) are susceptible to repeated episodes of hypoglycemia, which can result in impaired awareness of hypoglycemia (IAH). As a consequence, IAH contributes to diminished recognition of the need for external glucose. This can be a very risky situation for T1D individuals with IAH, possibly leading to coma and in some circumstances, death. The NIDDK is forming the IAH Consortium, which will conduct studies to determine if the most up-to-date management strategies using diabetes technology will restore awareness of hypoglycemia.

PI_NAMEs: CHINCHILLI, VERNON M (contact)

PROJECT_TERMS: Accountability;acute pancreatitis;Adherence;Adult;Adverse event;Advocacy;Ancillary Study;Awareness;Biological Assay;biomarker selection;Biometry;Blood Glucose;Caregivers;Cessation of life;clinical center;Clinical Research;Clinical Trials;Clinical Trials Data Monitoring Committees;Collaborations;Collection;college;Coma;Communication;Conduct Clinical Trials;Conflict of Interest;Continuous Glucose Monitor;cost;Data;Data Analyses;Data Coordinating Center;data exchange;data management;Data Management Resources;data submission;design;Development;Devices;Diabetes Mellitus;Digestive System Disorders;drug distribution;Enrollment;Ensure;Evaluation;Exclusion;experience;Family member;Funding;Glucose;Glycosylated hemoglobin A;Health Sciences;Healthcare Systems;Heterogeneity;Hypoglycemia;Impairment;improved;Individual;Institutional Review Boards;Insulin-Dependent Diabetes Mellitus;Internet;Investigational New Drug Application;Kidney Diseases;Laboratories;Lead;Manuals;Manuscripts;Measures;Medical;Medicine;member;Monitor;National Institute of Diabetes and Digestive and Kidney Diseases;participant enrollment;Patient Self-Report;Patients;Pennsylvania;Predisposition;Preparation;Procedures;Process;programs;Protocols documentation;Psychometrics;Public Health;Publications;quality assurance;Quality Control;Questionnaires;Randomized;recruit;Reporting;repository;Request for Applications;Research;Research Design;response;restoration;Safety;Safety Management;Sample Size;Security;Site Visit;Statistical Data Interpretation;Support System;System;Technology;Time;United States Food and Drug Administration;United States National Institutes of Health;Universities;Validation;Vendor;Visit;web site

PROJECT_TITLE: The Biostatistics Research Center for the Impaired Awareness of Hypoglycemia Consortium


ORG_CITY: HINES

ORG_NAME: EDWARD HINES JR VA HOSPITAL

ORG_STATE: IL

PHR: Relevance to the VA: The VA cares for nearly one million veterans with COPD at a cost of more than $5.5 billion annually. COPD profoundly impairs quality of life as it limits ability to work, to maintain physical exertion and to engage in social activities. Hospital-based rehab can decrease the need for inpatient and outpatient medical care and can improve exercise capacity, quality of life and, possibly, decrease mortality. Unfortunately, access to hospital-based VA rehab is insufficient and, over time, the few veterans who attend experience progressive loss of functional gains. We reason that our proposed home-based exercise program augmented by patient-tailored, RAS-enhanced music will overcome the many limitations of hospital-based rehab. Through our innovative program, we expect to enhance the benefits of rehab and better maintain them over time. The easy applicability of our innovative, accessible and economical program has the potential to modify the spiraling pattern of increasing disability and reduce health-care cost and mortality in veterans with COPD.

PI_NAMEs: LAGHI, FRANCO  (contact)

PROJECT_TERMS: Acoustic Stimulation;actigraphy;Adherence;airway obstruction;Analysis of Variance;Anxiety;Caring;Chronic Obstructive Pulmonary Disease;Clinic;Clinical;comparative efficacy;Control Groups;cost;Coupling;Data;Dimensions;disability;Dyspnea;efficacy evaluation;Eligibility Determination;Emergency department visit;emotional reaction;Enrollment;Ensure;Equipment;Exercise;exercise capacity;exercise intensity;exercise program;Exercise Tolerance;exercise training;Exertion;experience;experimental group;Fatigue;femoral nerve;follow-up;Foundations;Fright;functional gain;functional improvement;functional loss;functional status;Gait;group intervention;Health;Health Care Costs;Health Professional;health related quality of life;Home;Hospitalization;Hospitals;Impairment;improved;innovation;Inpatients;interest;Intervention;Linear Regressions;Lung;Magnetism;Measurement;Measures;Medical;Mental Depression;Methods;Modeling;mortality;Motor;Music;novel;Outcome Measure;Outpatients;participant enrollment;Patients;Pattern;Periodicity;Peripheral arterial disease;Phenotype;Physical activity;Physically Challenged;Physicians;Physiological;primary outcome;programs;Protocols documentation;psychologic;Psychological Factors;Pulmonary function tests;pulmonary rehabilitation;quadriceps muscle;Qualifying;Quality of life;Randomized;Randomized Controlled Clinical Trials;recruit;rehabilitation strategy;Rehabilitation therapy;response;Self Efficacy;Severities;social;Solid;success;symptomatic improvement;Symptoms;systemic inflammatory response;Testing;Time;Training;Transportation;Treadmill Tests;Ultrasonography;Veterans;Visit;Walking;walking speed;Work

PROJECT_TITLE: Increasing Physical Activity in COPD Through Rhythmically Enhanced Music


NIH_SPENDING_CATS: Autoimmune Disease;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Pediatric;Physical Activity

ORG_CITY: MELBOURNE

ORG_COUNTRY: AUSTRALIA

ORG_FIPS: AS

ORG_NAME: UNIVERSITY OF MELBOURNE

PHR: Project Narrative Impaired hypoglycemia awareness (IAH), present in 25% of people with type 1 diabetes, increases the risk of severe hypoglycemia, which adversely effects their physical and psychological well-being and productivity and impacts their families and communities. Furthermore, the consequent fear of hypoglycemia may lead to reluctance by the person with diabetes and their carers to target optimal glucose levels, thus increasing their risk of long-term diabetes complications. Interventions proposed herein, utilizing widely available tools, will improve our understanding of IAH, should improve hypoglycemia awareness and substantially benefit many people with type 1 diabetes and society.

PI_NAMEs: JONES, TIM ;O'NEAL, DAVID NORMAN (contact)

PROJECT_TERMS: Adolescence;Adrenergic Agents;Adult;Adverse effects;Affect;American;Awareness;Benchmarking;blood glucose regulation;Carbohydrates;Child;Childhood;Closure by clamp;cohort;Communities;Complications of Diabetes Mellitus;Continuous Glucose Monitor;Data;Defect;Diabetes Mellitus;Dose;Education;effective intervention;Eligibility Determination;Epinephrine;Evolution;Exercise;exercise program;Family;Fright;Funding;Glucagon;Glucose;glucose production;Gold;high risk;Hormones;Hypoglycemia;Immunosuppression;Impairment;improved;Individual;insight;Insulin;Insulin-Dependent Diabetes Mellitus;Intervention;Islets of Langerhans Transplantation;Knowledge;Manuals;Modernization;mortality;new technology;Outcome;Participant;Pediatric cohort;Persons;population based;preservation;primary outcome;Productivity;programs;psychoeducation;psychological outcomes;Randomized;Randomized, Controlled Trials;Recurrence;Reporting;Research;Resources;response;restoration;Risk;Risk Reduction;Role;Site;Societies;Structure;success;Symptoms;Syndrome;System;Technology;Time;tool;treatment as usual;Well in self

PROJECT_TITLE: Characterizing the evolution of impaired hypoglycemia awareness in people with type 1 diabetes and the impact of automated insulin delivery and exercise on restoring hypoglycemia awareness


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Genetics;Orphan Drug;Pediatric;Primary Immunodeficiencies;Rare Diseases

ORG_DEPT: PEDIATRICS

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE Primary Immunodeficiency Disorders (PIDD), like other rare diseases, have suffered from a lack of clinical trials to study new therapies because of the relatively small number of patients affected with each specific disorder. To address this barrier, we plan to take a new approach to clinical trial design in PIDD, namely the use of a basket clinical trial to study patients with multiple genetic immune disorders that share related mechanistic underpinnings (STAT1 gain of function (STAT1 GOF), STAT3 GOF, STAT5b GOF, and JAK1 GOF) that will be treated with a single, targeted therapy (Itacitinib, a second-generation JAK1 inhibitor) in a phase I/II safety and efficacy trial. Clinical evaluation will be paired with deep profiling of the immune system before and after treatment to judge efficacy in each different disease.

PI_NAMEs: FORBES, LISA  (contact);TORGERSON, TROY R

PROGRAM_OFFICER_NAME: BROOKS, PJ

PROJECT_TERMS: Address;Affect;Aftercare;ATAC-seq;atopy;Autoimmunity;autoinflammation;Binding;Biological;Biological Markers;biomarker identification;Bone Marrow Transplantation;Cell Nucleus;Cells;Clinical;Clinical assessments;clinical development;Clinical Research;clinical trial protocol;Clinical Trials;Clinical Trials Design;Collaborations;congenital immunodeficiency;cytokine;Data;Defect;Dimerization;Disease;DNA;DNA Binding;Dose;early onset;effective therapy;efficacy trial;Exhibits;experience;FDA approved;Flow Cytometry;Future;gain of function;gain of function mutation;Gene Expression;Generations;Genes;Genetic;Growth Factor;Heterozygote;Homeostasis;Immune;immune function;Immune response;Immune signaling;Immune system;Immune System Diseases;Immunologic Deficiency Syndromes;Immunologist;inhibitor therapy;innovation;interest;JAK1 gene;Janus kinase;kinase inhibitor;member;Mission;Modeling;Molecular;Molecular Profiling;Mutation;Natural History;novel strategies;novel therapeutics;off-label use;Outcome;Pathway interactions;Patient Care;patient population;Patients;Pharmaceutical Preparations;Pharmacologic Substance;Phase;Phase I/II Clinical Trial;Phenotype;Phosphorylation;Phosphotransferases;Plasma Proteins;Precision therapeutics;Preparation;Proteins;Provider;Publishing;Rare Diseases;rare genetic disorder;recurrent infection;Regulation;Research;research clinical testing;Research Design;response;Safety;safety assessment;Shapes;Signal Pathway;Signal Transduction;Signaling Protein;single-cell RNA sequencing;small molecule;STAT protein;STAT1 gene;STAT3 gain of function;STAT3 gene;STAT5B gene;targeted treatment;Testing;Therapeutic;therapeutic target;Therapeutic Trials;therapeutically effective;transcription factor;Treatment Efficacy;treatment response;treatment trial;Treatment-related toxicity;TYK2;Tyrosine;United States National Institutes of Health;Work

PROJECT_TITLE: Safety and Efficacy of Itacitinib in treatment of JAK/STAT pathway disorders with activating mutations


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Down Syndrome;Intellectual and Developmental Disabilities (IDD);Neurodegenerative;Neurosciences

ORG_CITY: TUCSON

ORG_NAME: ILUMINOS THERAPEUTICS, LLC

ORG_STATE: AZ

PHR: Project Narrative Down syndrome (DS) is the most common genetic form of intellectual and cognitive disability, occurring in ~1 in 700 live births. DS patients also experience age-related progressive cognitive decline, neurodegeneration, and the development of Alzheimer's disease (AD)-like pathology, for which there are no therapeutic options. The chromosome 21 gene, Dyrk1a, is associated with this progressive cognitive decline and AD-like neuropathology and Iluminos Therapeutics’ unique small molecule inhibitor, which we propose to test in in vivo DS mice and to progress through IND-enabling studies herein, holds significant promise as a first-in-class treatment approach in Down syndrome.

PI_NAMEs: DUNCKLEY, TRAVIS  (contact);HULME, CHRISTOPHER

PROGRAM_OFFICER_NAME: GILCHRIST, FLOY ANNETTE

PROJECT_TERMS: 3xTg-AD mouse;Acute;age related;Age Years;Alzheimer like pathology;Alzheimer's Disease;Alzheimer's disease model;amyloid pathology;Behavior;Biological Assay;Brain;Canis familiaris;Chromosome 21;Chronic;Clinical Trials;Cognition;Cognitive;Cognitive deficits;cognitive disability;commercialization;Data;design;Development;disease phenotype;Down's Syndrome;Enzyme-Linked Immunosorbent Assay;Exhibits;experience;Gene Dosage;Genes;Genetic;Hippocampus;Human Chromosomes;Immunohistochemistry;Impaired cognition;improved;In Vitro;in vivo;inhibitor;Intellectual functioning disability;Laboratories;Lead;lead optimization;Learning;Link;Live Birth;Medical;Metabolic;Methods;micronucleus;Modeling;Motor;mouse model;mouse Ts65Dn;Mus;Nerve Degeneration;Neuroanatomy;neurobehavior;neurodegenerative phenotype;neuropathology;overexpression;Pathologic;Patients;Pharmaceutical Chemistry;Pharmaceutical Preparations;Pharmacology;Phase;Phosphorylation;Phosphorylation Inhibition;Phosphotransferases;Plasma;Preparation;prevent;Rattus;Roentgen Rays;Safety;Science;Services;Small Business Technology Transfer Research;small molecule inhibitor;Specificity;Structure;tau-1;Testing;Therapeutic;therapeutic target;tool;Toxic effect;Toxicogenetics;Toxicology;Translating;Tyrosine;Validation;Western Blotting

PROJECT_TITLE: Commercialization of Selective Dyrk1a Inhibitors for Down Syndrome


ORG_CITY: MIAMI

ORG_NAME: MIAMI VA HEALTH CARE SYSTEM

ORG_STATE: FL

PHR: The Veterans Health Administration (VHA) acknowledges greater need for improvement in stroke prevention and post-stroke care. Post-stroke frailty and cognitive decline are significant problems. Identifying novel neuroprotective strategies to improve post-stroke cognition remains a high priority. In the current proposal we will test the treatment efficacy of combining therapeutic hypothermia and whole body vibration on post-stroke cognitive improvement in aged rats. Our study will provide a novel therapeutic approach for rehabilitation of stroke patients.

PI_NAMEs: BRAMLETT, HELEN M;RAVAL, AMI P (contact)

PROJECT_TERMS: Acute;Adoptive Transfer;Affect;aged;Animal Model;behavioral study;Body Weight decreased;Brain;Brain hemorrhage;Caring;Cause of Death;Cerebral Ischemia;Clinic;Clinical;Clinical Trials;Cognition;Cognitive;Communication;Communities;cost;cytokine;Data;Deterioration;disability;efficacy testing;Exercise;extracellular vesicles;Fatigue;Fingerprint;frailty;Frequencies;Future;Gait speed;Genes;glucose metabolism;Goals;Hippocampus;Home;Hormone secretion;hormone therapy;Hormones;Human;Impaired cognition;improved;in vivo;indexing;Infarction;Inflammation;Inflammatory;insight;Intervention;Ischemia;Ischemic Brain Injury;Ischemic Stroke;Laboratories;Laboratory Animals;Link;Mechanics;Mediating;middle age;Middle Cerebral Artery Occlusion;Midlife women;Mitochondria;mitochondrial dysfunction;Modeling;Monitor;mortality;motor deficit;motor learning;Muscle;natural hypothermia;neurobehavior;neuroinflammation;neuronal survival;Neurons;neuroprotection;novel;novel therapeutic intervention;out-of-hospital cardiac arrest;Outcome;Patients;Physical activity;Physical Exercise;Physiological;Pilot Projects;post stroke;post stroke cognitive impairment;preclinical study;Proteomics;Quality of life;Rattus;Recovery;Research;response;Role;Serum;sex;Skeletal Muscle;spinal cord and brain injury;Stroke;stroke model;stroke outcome;stroke patient;Stroke prevention;stroke rehabilitation;stroke risk;stroke survivor;Temperature;Testing;Therapeutic;Therapeutic Effect;Therapeutic Intervention;thrombolysis;Tissues;transcriptional reprogramming;transcriptomics;Transient Ischemic Attack;Translating;translational goal;Treatment Efficacy;United States Department of Veterans Affairs;Vesicle;Veterans;Veterans Health Administration;vibration

PROJECT_TITLE: Therapeutic interventions for post-stroke rehabilitation


ADMINISTERING_IC: MD

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Cancer;Clinical Research;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Patient Safety;Rural Health;Social Determinants of Health;Uterine Cancer;Women's Health Research

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE This project will provide the preliminary data for an R01 application to test an endometrial cancer navigation intervention against usual care using a Type 1, hybrid effectiveness-implementation design. Findings from this future R01 research will contribute to reducing disparities in the treatment and outcomes of rural endometrial cancer patients. Additionally, the current proposal will provide a model for how to effectively design implementation-ready, pragmatic patient navigation interventions to reduce disparities among other medically underserved patient populations.

PI_NAMEs: SPEES, LISA PATTERSON (contact)

PROGRAM_OFFICER_NAME: PATEL, ANURADHA DIPAK

PROJECT_TERMS: Academic Medical Centers;Address;Adherence;Administrator;barrier to care;cancer care;cancer health disparity;Cancer Patient;cancer therapy;Caring;Cause of Death;Client satisfaction;Clinical Nurse Specialists;Colorectal Cancer;community engaged research;cost;cost effective intervention;Data;design;Disease;Disparity;disparity reduction;Effectiveness;effectiveness/implementation design;effectiveness/implementation trial;Endometrial Carcinoma;Ensure;Equity;evidence base;Evidence based intervention;Future;Goals;Guidelines;Gynecologic Oncologist;Gynecologic Oncology;Health;health disparity;Hospitals;implementation design;implementation evaluation;Implementation readiness;implementation science;implementation strategy;improved;Intervention;intervention mapping;Intervention Studies;Interview;Malignant Breast Neoplasm;Malignant Female Reproductive System Neoplasm;Malignant Neoplasms;Medical Oncology;medically underserved;medically underserved population;Mission;Modeling;mortality;National Institute on Minority Health and Health Disparities;novel;Oncology;Operative Surgical Procedures;Outcome;Outcome Study;patient navigation;patient population;Patients;Population;programs;Quality of Care;Radiation Oncologist;Research;Research Methodology;Research Personnel;Risk;Rural;rural area;Rural Community;rural disparities;rural dwellers;rural patients;Structure;systematic review;Testing;theories;therapy design;Time;tool;Training;Travel;treatment and outcome;treatment as usual;treatment disparity;Underserved Population;urban area;Variant;Woman

PROJECT_TITLE: Patient Navigation in Gynecologic Oncology: Improving Care among Rural Endometrial Cancer Patients


ADMINISTERING_IC: DE

ED_INST_TYPE: UNIVERSITY-WIDE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Genetics;Human Genome;Pediatric

ORG_CITY: EUGENE

ORG_NAME: UNIVERSITY OF OREGON

ORG_STATE: OR

PHR: Craniofacial disorders are among the most common birth defects in humans and are often congenital, caused by mutations in protein coding or regulatory sequences of deeply conserved developmental genes active in cranial neural crest cells. To better understand how gene regulatory networks respond to mutations in these conserved genes, we propose using pipefish, seahorses, and seadragons which not only have very unique faces but have also lost several of these genes. Our work will discover how regulatory networks can compensate for the loss of key genes that lead to alterations in craniofacial development and will improve our understanding of the developmental genetic basis of human craniofacial disorders.

PI_NAMEs: HEALEY, HOPE M (contact)

PROGRAM_OFFICER_NAME: FUQUA, CHANTEL FAYSAN

PROJECT_TERMS: Amaze;Animal Model;animal model selection;Atlases;Biological Assay;bone;Branchial arch structure;Cartilage;cartilage development;Cells;Cephalic;Chromatin;Cleft Palate;Clustered Regularly Interspaced Short Palindromic Repeats;Code;Compensation;Congenital Abnormality;craniofacial;Craniofacial Abnormalities;craniofacial bone;craniofacial development;craniofacial disorder;Craniosynostosis;cranium;Data;Deglutition Disorders;Developmental Gene;developmental genetics;Disease;Elements;Enhancers;epigenomics;Ethmoid bone structure;Etiology;Exhibits;Face;Fishes;Gasterosteidae;gene conservation;Gene Expression;Gene Expression Profile;gene function;Gene Modified;gene network;gene regulatory network;Genes;Genetic;Genetic Induction;Genetic Transcription;genome annotation;genome-wide;Genus Hippocampus;Goals;Head;Health;Human;human disease;improved;In Situ Hybridization;Induced Mutation;Knock-out;Knowledge;Laboratory Study;Libraries;member;Microcephaly;Modeling;Morphology;mutant;Mutation;Neural Crest;Neural Crest Cell;novel;Odontoma;Organism;Outcome;Pathway Analysis;Patients;Phenocopy;premature;Proteins;Regulatory Element;Research;Resolution;RNA;Role;Signal Transduction;single cell analysis;single cell ATAC-seq;single cell sequencing;single-cell RNA sequencing;Skeleton;Structure;Symptoms;Syndrome;System;Technology;Testing;tool;Tooth Loss;Tooth structure;tumor;Untranslated RNA;Variant;Vertebrates;whole genome;Work;Zebrafish

PROJECT_TITLE: Discovery of craniofacial genes capable of compensation through evolutionary mutant model

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


NIH_SPENDING_CATS: Back Pain;Behavioral and Social Science;Brain Disorders;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Mental Health;Neurosciences;Opioid Misuse and Addiction;Opioids;Pain Research;Prevention;Rehabilitation;Substance Misuse

ORG_CITY: ELKRIDGE

ORG_NAME: EVON MEDICS, LLC

PHR: NARRATIVE In contrast to acute pain, which is a common and an often-transient experience necessary for survival, chronic pain is a detrimental pathological state that drives changes in the orbitofrontal cortex (OFC) and associated prefrontal (PFC) brain regions – needed for cognitive functions, modulation of the descending inhibitory pain pathway and emotion regulation – culminating in high negative affect, cognitive impairments and amplification of pain suffering that defies current treatments. Our proposal seeks to develop a patient-centered, cost- effective alternative strategy – the chemosensory-based Computerized Orbitofrontal Cortex Training (CBOT-Pain) – for rapid and sustained relief of pain and negative affect through home-based noninvasive olfactory stimulation of the canonical secondary olfactory cortex (i.e., the OFC). Accomplishment of the Aims of this proposal would lead to a breakthrough product that closes the unmet need for treatment of more than 700 million people globally with chronic pain and high negative affect through (1) attenuation of chronic pain-associated OFC/PFC shrinkage, (2) rapid and sustained relief of pain and negative affect, and (3) improvement of OFC/PFC-dependent cognitive functions.

PI_NAMEs: NWAOKOBIA, CHARLES CHIEDU (contact);NWULIA, EVARISTUS A

PROGRAM_OFFICER_NAME: FORBES, JESSICA CARLENE

PROJECT_TERMS: Acute;Acute Pain;Affect;Affective;Agonist;American;Analgesics;anatomical tracing;Anatomy;Animal Model;anti-depressive agents;Anti-Inflammatory Agents;Anticonvulsants;antinociception;Anxiety;attenuation;Behavior Therapy;Beta-caryophyllene;Brain;Brain region;Businesses;central pain;Cessation of life;chronic back pain;Chronic low back pain;chronic pain;chronic pain management;chronic pain patient;chronic painful condition;Clinical;Cognition;Cognitive;cognitive function;Collaborations;combinatorial;Communities;comorbidity;computerized;cost effective;Data;Decision Making;Deep Brain Stimulation;Development;Devices;digital;disability;Dose;Drug Addiction;drug relapse;effective intervention;effective therapy;Effectiveness;effectiveness/implementation study;efficacy study;Electric Stimulation;Electrodes;emotion regulation;Emotions;Endocannabinoids;Enrollment;Evaluation;Exercise;experience;Feasibility Studies;Financial Hardship;Fortification;functional loss;Funding;gray matter;habituation;Home;Human;Impaired cognition;improved;innovation;interest;Intervention;Intractable Pain;Lateral;Long-Term Effects;Manufacturer;Marketing;Measures;Medial;Medicare/Medicaid;Mental Depression;midbrain central gray substance;Midbrain structure;Mindfulness Training;Moods;Motivation;multisensory;Narcotic Analgesics;National Institute of Drug Abuse;negative affect;nerve damage;neuromechanism;Neuronal Plasticity;neuroregulation;Neurosciences;non-opioid analgesic;Olfactory Cortex;Operative Surgical Procedures;Opioid Analgesics;opioid misuse;opioid use;opioid use disorder;Outcome;Overdose;Pain;pain chronification;Pain Clinics;Pain intensity;Pain management;pain patient;pain processing;pain reduction;pain relief;pain sensitivity;Pathologic;Pathway interactions;patient oriented;Patients;Persons;Phase;Physiologic pulse;Phytochemical;Pilot Projects;Play;Population;Prefrontal Cortex;prevent;Prevention;Process;programs;Provider;Psychophysics;Randomized;randomized trial;Randomized, Controlled Trials;receptor;Regimen;Regulation;Research;Research Personnel;response;Rewards;Role;Safety;Sensory;sensory integration;Severities;side effect;Site;Small Business Innovation Research Grant;Stimulant;Stimulus;stimulus interval;Structure;Subgroup;success;Technology;Testing;Time;Training;treatment as usual;trend;Universities;user-friendly

PROJECT_TITLE: Development and Evaluation of Computerized Chemosensory-Based Orbitofrontal Networks Training for Treatment of Pain (CBOT-P)


NIH_SPENDING_CATS: Back Pain;Behavioral and Social Science;Bioengineering;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Neurosciences;Pain Research;Physical Activity;Physical Rehabilitation;Rehabilitation

ORG_CITY: YPSILANTI

ORG_NAME: ARBOR MEDICAL INNOVATIONS, LLC

PHR: NARRATIVE Physicians struggle to assess the true influence on patients of interventions for chronic low back pain. This creates a significant barrier to their ability to help patients rapidly regain their quality of life. This application aims to provide a service for physicians, supported by a disposable and burden-free patient wearable, that can provide quantitative and objective assessments of daily physical activity to support physician decision making.

PI_NAMEs: KRUGER, GRANT H (contact)

PROGRAM_OFFICER_NAME: HUDAK, ERIC MICHAEL

PROJECT_TERMS: Absenteeism;Accelerometer;actigraphy;Address;Adopted;Adoption;Adult;Agreement;Algorithmic Analysis;Area;Back;Bluetooth;California;Charge;Chronic low back pain;chronic pain;chronic pain management;chronic painful condition;Clinic;Clinical;clinical care;clinical decision support;clinical decision-making;clinical practice;Clinical Research;clinical research site;commercialization;Computer software;Consensus;cost;Current Procedural Terminology Codes;daily functioning;Data;Data Analyses;Decision Making;design;Development;Devices;Ensure;Exhibits;experience;FDA approved;Focus Groups;functional disability;Future;Generations;Healthcare;Individual;Infrastructure;innovation;Innovation Corps;Intervention;Interview;Kansas;Laboratories;Low Back Pain;Marketing;Measures;Medical;Medical center;Memory;Methods;Michigan;Monitor;Multi-site clinical study;Notification;Output;Pain;Pain Assessment Tool;Pain Clinics;Pain management;Pain Measurement;pain patient;pain-related disability;Patient Monitoring;Patient Self-Report;Patients;Phase;Physical activity;Physical Function;Physicians;post-market;prevent;Process;Production;programs;prototype;Provider;Publishing;Quality of life;Questionnaires;Recovery;recruit;Regulation;Reporting;Research;response;Sampling;satisfaction;Self-Examination;Services;Specialist;Standardization;success;Symptoms;System;Technology;Time;Treatment Cost;treatment effect;treatment response;United States National Institutes of Health;Universities;usability;Validation;wearable device;wearable monitor;wireless fidelity;Work

PROJECT_TITLE: Actigraphy Enhanced Clinical Chronic Lower Back Pain Management


ORG_CITY: GAINESVILLE

ORG_NAME: VETERANS HEALTH ADMINISTRATION

PHR: Approximately 15,000 Veterans are hospitalized for stroke each year with new cases costing an estimated $111 million for acute inpatient, $75 million for post-acute inpatient, and $88 million for follow-up care over 6 months post-stroke. We have previously established the effectiveness of a backward walking training program to improve gait and balance in post-stroke Veterans. To best serve our Veterans in this era of personalized medicine, there is a current need to determine the appropriate training dose as well as which post-stroke Veterans would most benefit. This study addresses both needs as it will 1) test responses to two different doses (18 vs. 27 sessions) of backward walking training and 2) assess brain activity, measured by magnetic resonance imaging, before and after training intervention to determine its ability to predict rehabilitation response as well as brain mechanisms of behavioral change.

PI_NAMEs: ROSE, DORIAN K (contact)

PROJECT_TERMS: Acute;acute stroke;Address;Adopted;Ankle;Area;Balance training;Behavior Therapy;Behavioral;Behavioral Mechanisms;behavioral response;Blood flow;blood oxygen level dependent;Body Weight;Brain;Brain imaging;brain magnetic resonance imaging;Brain region;Cardiac;Caring;Cerebrovascular Disorders;Characteristics;chronic stroke;Clinical;clinical application;clinical care;clinical practice;Clinical Trials;Communities;comparison intervention;Contralateral;cost estimate;Data Analyses;Decision Making;design;dosage;Dose;Educational Intervention;Effectiveness;effectiveness study;equilibration disorder;Equilibrium;evidence based guidelines;fall risk;falls;follow-up;Functional Magnetic Resonance Imaging;Gait;gait rehabilitation;Gait speed;Hospitalization;Impairment;improved;improved mobility;indexing;Individual;Individual Differences;Infarction;Inpatients;insight;interest;Intervention;intervention program;Knowledge;Laboratories;Learning;Lesion;Lower Extremity;Magnetic Resonance;Magnetic Resonance Imaging;Measurement;Measures;Medical center;Medical Device;medical implant;Metals;Methods;Motion;Motor;motor impairment;motor recovery;neural network;Neurologic;neurological rehabilitation;neurophysiology;novel;Orthopedics;Outcome;Outcome Measure;Pain;Participant;Patients;Performance;personalized medicine;Persons;Physical Rehabilitation;post intervention;post stroke;predicting response;Prediction of Response to Therapy;primary outcome;Publishing;Randomized;Randomized, Controlled Trials;Recovery;Recovery of Function;rehabilitation research;Rehabilitation therapy;Research;Research Design;Resources;response;Rest;Sample Size;Sampling;secondary analysis;Self Efficacy;Sensory impairment;Signal Transduction;Single-Blind Study;skills;Specific qualifier value;Step training;Stroke;stroke rehabilitation;System;Testing;therapeutic effectiveness;Therapeutic Intervention;Training;Training Programs;treadmill;Veterans;Walking;walking rehabilitation;walking speed;Work

PROJECT_TITLE: Brain and Behavioral Responses to Backward Walking Training Post-Stroke


ORG_CITY: PORTLAND

ORG_NAME: PORTLAND VA MEDICAL CENTER

PHR: The purpose of the proposed research is to examine the immediate audibility effects and long- term auditory-processing effects of amplification. Use of brain and behavioral outcomes to measure the effects of hearing aids may help to clarify the positive impacts of hearing aids as a rehabilitation approach and lead to additional individualization of the treatment of hearing loss and tinnitus.

PI_NAMEs: BILLINGS, CURTIS J (contact)

PROJECT_TERMS: Acclimatization;Acoustics;Address;Affect;Age;age effect;Aging;Auditory;auditory processing;auditory rehabilitation;Auditory Threshold;Behavior;behavior test;Behavioral;behavioral outcome;Brain;candidate identification;Caring;Categories;Characteristics;Clinic;Clinical;Cognition;Cognitive;cognitive ability;cognitive testing;Communication;Complex;Cues;Data;Data Set;disability;Effectiveness;Electrophysiology (science);Goals;Hearing Aids;hearing impairment;hearing loss treatment;improved;Individual;individual variation;individualized medicine;innovation;Intervention;Life;Life Style;Long-Term Effects;longitudinal course;Longitudinal Studies;Measurement;Measures;Methods;Modality;Modeling;Modification;neural;Noise;Normal Range;Outcome;Outcome Measure;Patients;Physiological;Psychophysics;psychosocial;Quality of life;Questionnaires;Rehabilitation therapy;Research;Sampling;Services;Source;Speech;speech accuracy;Speech Perception;Stimulus;Subgroup;success;Testing;Time;Tinnitus;Veterans

PROJECT_TITLE: Hearing Aid Effects on Brain and Behavior


PHR: Over 15,000 Veterans are hospitalized for stroke annually, leading to combined costs for acute, post-acute, and follow-on care exceeding $274 million. As the baby boom generation (individuals born from 1946-1964) ages, the prevalence of stroke in Veterans is anticipated to more than double. While stroke can occur at any age, stroke risk doubles by decade after age 55. Male Veterans, who currently average 64 years of age, reveal an 81% increased stroke risk compared to non-veteran age counterparts. Due to the significant impact of stroke on quality of life, improvements in prognosis, intervention, and clinical care are therefore critical to the future of Veterans' healthcare. The large proportion of baby boom era Veterans, disproportionately represented by males with substantially elevated stroke risk, underscores the importance of accelerating discoveries that will maximize recovery, restore activity participation, and optimize quality of life for Veterans with stroke-related disability. Resulting advances in neurorehabilitation will place the VHA at the forefront of this critical healthcare need.

PI_NAMEs: PATTEN, CAROLYNN  (contact)

PROJECT_TERMS: Acceleration;Acute;acute care;Adult;Age;age related;Age Years;Aging;American Physical Therapy Association;Area;Award;Baby Booms;Behavior;Behavioral;Biological Markers;Biological Sciences;biomarker development;Biomechanics;Biomedical Engineering;Brain;Brain Injuries;California;career;Caring;central nervous system injury;Characteristics;chronic stroke;Clinical;clinical care;clinical decision-making;Clinical Medicine;Clinical Practice Guideline;clinical predictive model;Clinical Trials;cohort;Collaborations;college;Computer Models;cost;Critical Care;Cross-Sectional Studies;Data;Data Reporting;density;design;Development;disability;Discipline;Elderly;Electroencephalography;evidence base;experience;Female;Flexor;Florida;Foundations;Functional disorder;fundamental research;Future;Gait;Generations;Genetic Variation;Goals;Healthcare;Healthcare Systems;Heterogeneity;Hospitalization;Human;Hyperreflexia;Impairment;improved;Individual;Influentials;inpatient service;Intervention;Investigation;kinematics;Kinetics;Learning;Limb structure;Locomotion;male;Measures;Medical center;medical schools;Methods;Motion;Motor;motor control;motor disorder;motor impairment;motor learning;motor recovery;Movement;Nervous System;neural;Neurobiology;neuroimaging;neurological rehabilitation;Neuromechanics;neuromechanism;Neuronal Plasticity;neuropathology;neurophysiology;Neurosciences;Neurosciences Research;novel;Outcome;Paper;Pathology;Performance;Persons;Physical Medicine;Physical Rehabilitation;physical therapist;Physical therapy;Physiological;Physiology;Positioning Attribute;post stroke;potential biomarker;Prevalence;Principal Investigator;Process;Production;professor;Prognosis;programs;Quality of life;Recommendation;Recovery;Reflex action;rehabilitation research;Rehabilitation therapy;remediation;Research;research and development;Research Personnel;Research Support;responders and non-responders;response;Role;Scientist;Seminal;Series;Services;Site;statistics;Stress;Stroke;stroke intervention;stroke recovery;stroke rehabilitation;stroke risk;stroke survivor;Subgroup;Therapeutic;Therapeutic Intervention;Transcranial magnetic stimulation;translational goal;translational neuroscience;Translational Research;Universities;Veterans;Veterans Health Administration;Walking;Work

PROJECT_TITLE: RR&D Research Career Scientist Award Application

STUDY_SECTION_NAME: Research Career Scientist[RRD7]


PHR: The population of older Veterans with non-traumatic lower limb amputation is growing. Following lower limb amputation, asymmetrical movements persist during walking and likely contribute to disabling sequelae including secondary pain conditions, poor gait efficiency, impaired physical function, and compromised skin integrity of the residual limb. The proposed study seeks to address chronic gait asymmetry by evaluating the efficacy of two error-manipulation gait training programs to improve gait symmetry for Veterans with non- traumatic lower limb amputation. Additionally, this study will evaluate the potential of error-manipulation training programs to improve secondary measures of disability and residual limb skin health. Ultimately, the proposed study aims to improve conventional prosthetic rehabilitation for Veterans with non-traumatic amputation through gait training programs based in motor learning principles, resulting in improved gait symmetry and lower incidence of long-term disability after non-traumatic lower limb amputation.

PI_NAMEs: CHRISTIANSEN, CORY L (contact)

PROJECT_TERMS: Acute;Address;Amputation;Ankle;arm;Auditory;biobehavior;Characteristics;Chronic;chronic stroke;clinical translation;comorbidity;comparison control;Compensation;Control Groups;control theory;Data;Degenerative polyarthritis;Development;Diabetes Mellitus;Disabilities experience;disability;Disability outcome;Disability scale;Disabling;Educational Intervention;efficacy evaluation;Etiology;Exhibits;Feedback;follow-up;Gait;gait correction;gait rehabilitation;gait symmetry;Goals;group intervention;Health;Hip region structure;human old age (65+);Impaired healing;improved;Incidence;Individual;Intervention;Knee;Knowledge;Length;limb amputation;limb loss;limb movement;Limb structure;Long term disability;Low Back Pain;Lower Extremity;Measures;Mechanics;military veteran;Motor;motor control;motor learning;Movement;Nervous System;neuromuscular system;novel;Older Population;Outcome;Pathology;Patient Self-Report;Pattern;Performance;Peripheral arterial disease;Persons;Physical activity;Physical Function;physical impairment;Physical Performance;physically handicapped;Population;Populations at Risk;primary endpoint;primary outcome;prosthesis fitting;Prosthetic rehabilitation;prosthetic socket;Protocols documentation;Randomized, Controlled Trials;Rehabilitation therapy;residual limb;residual limb health;response;secondary outcome;Secondary pain;Secondary to;Severities;Signal Transduction;Skin;Specificity;standard of care;Testing;Training;Training Programs;Transcutaneous Oximetry;Translating;Traumatic Amputation;treadmill;Veterans;Walking;walking performance;Work;World Health Organization;wound

PROJECT_TITLE: Optimizing Gait Rehabilitation for Veterans with Non-Traumatic Lower Limb Amputation


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_CITY: ANN ARBOR

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: PROJECT NARRATIVE Hypothalamic astrocytes form a core, yet incompletely understood, component of the neural circuit underlying reproduction. This project will interrogate to what extent astrocytes regulate elements of the reproductive control circuit and the mechanisms by which astrocytes and neurons residing in this circuit communicate. The findings of this proposal will further our understanding of the mechanisms underlying typical reproduction and may point to novel therapeutic targets for treatment of infertility.

PI_NAMEs: PHILLIPS, CHRYSTIAN DAVID (contact)

PROGRAM_OFFICER_NAME: RAVINDRANATH, NEELAKANTA

PROJECT_TERMS: Address;Adult;Affect;Anterior Pituitary Hormones;Astrocytes;Back;Brain;Brain region;Calcium;Cell Culture Techniques;Central Nervous System;Communication;Contraceptive methods;Coupled;Couples;CRISPR/Cas technology;Cytoplasm;Data;Diestrus;Dinoprostone;Dynorphins;Electrophysiology (science);Elements;Etiology;Exhibits;experimental study;Feedback;Female;Fertility;Follicle Stimulating Hormone;gamma-Aminobutyric Acid;Genes;Genetic;Glial Fibrillary Acidic Protein;Glutamates;gonad function;Gonadal Steroid Hormones;Gonadotropin Hormone Releasing Hormone;Guide RNA;High Pressure Liquid Chromatography;Homeostasis;Hormone secretion;Hypothalamic structure;Image;In Vitro;in vivo;Infertility;infertility treatment;Information Networks;Investigation;KISS1 gene;knock-down;Ligands;Luteinizing Hormone;male;Mediator;Metabotropic Glutamate Receptors;Methods;Modeling;Monitor;Morphology;mouse model;Mus;Nervous System Disorder;Nervous System Physiology;neural;neural circuit;neural network;Neuroglia;Neurokinin B;Neuromuscular Diseases;Neurons;Neurosecretory Systems;neurotransmission;new therapeutic target;Optics;Output;Ovulation;Pathway interactions;Population;Preoptic Areas;Process;Production;Proestrus;receptor;Receptor Signaling;Regulation;Reproduction;reproductive;reproductive function;RNA delivery;Rodent;Role;sex;Sex Differences;Sex Differentiation;Sexual Maturation;Signal Transduction;Slice;Steroid biosynthesis;Steroids;Structure of nucleus infundibularis hypothalami;synaptic function;synaptogenesis;Testing;therapeutic target;Time;Transgenic Mice;Vertebrates;Viral Vector;Work

PROJECT_TITLE: A role for hypothalamic astrocytes in neural circuits controlling reproduction


ORG_CITY: BEDFORD

ORG_NAME: EDITH NOURSE  ROGERS MEMORIAL VETERANS HOSPITAL

PHR: Criminal justice involvement and recidivism are highly prevalent among Veterans and important social determinants of health. Few treatment options with demonstrated effectiveness are available for Justice- Involved Veterans (JIVs). New comprehensive treatments such as Maintaining Independence and Sobriety Through Systems Integration, Outreach, and Networking-Criminal Justice Edition (MISSION-CJ) are emerging and aim to reduce criminal recidivism, improve treatment access and engagement and address other health- related risk factors underlying recidivism (i.e., substance use, mental health, housing, and employment problems). This study will be run in Mental Health Residential Rehabilitation Treatment Programs, and intends to compare MISSION-CJ versus Enhanced Usual Care, the latter of which includes a structured peer support curriculum as well as community outreach and linkage support. The long-term goal is to help the VA reduce criminal recidivism among JIVs, and improve the long-term health of this vulnerable Veteran population.

PI_NAMEs: BLONIGEN, DANIEL MICHAEL;SMELSON, DAVID A (contact)

PROJECT_TERMS: Acceleration;addiction;Address;Admission activity;Adoption;anti social;antisocial behavior;Attitude;Behavior;behavioral health;Caring;Case Manager;Charge;Chronic;Cognition;Communities;community based care;Community Integration;Community Outreach;community reintegration;Community Services;Continuity of Patient Care;Criminal Justice;Disease;disparity reduction;Education;Educational Curriculum;Effectiveness;effectiveness testing;Elements;Employment;Enrollment;Equipment and supply inventories;Evidence based treatment;follow-up;formative assessment;Future;future implementation;Goals;handbook;Health;health equity;Health Services Accessibility;Homeless persons;Homelessness;Housing;hybrid type 1 design;Hybrids;implementation trial;Imprisonment;improved;Individual;innovation;Intervention;Interview;Justice;Knowledge;Learning;Legal;Legal system;Link;Manuals;Measures;Mediating;Mental Health;Mental Health Court;Mental Health Services;Methodology;military veteran;Mission;Modeling;Monitor;Needs Assessment;novel;Outcome;outreach;peer;peer support;Personal Satisfaction;Population;prevent;programs;Provider;psychosocial;Randomized;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;recidivism;Rehabilitation therapy;Research;Resources;Risk;Risk Assessment;Risk Factors;Running;service delivery;service engagement;service gap;Services;Site;sobriety;social cognition;social health determinants;Specialist;Standardization;Structure;Subgroup;substance use;Substance Use Disorder;Suicide prevention;Supervision;System;Systems Integration;tool;Trauma;treatment as usual;treatment planning;treatment program;Unemployment;Veterans;Work

PROJECT_TITLE: A Randomized Controlled Trial of MISSION-CJ for Justice-Involved Homeless Veterans with Co-Occurring Substance Use and Mental Health

STUDY_SECTION_NAME: HSR-4  Mental and Behavioral Health[HSR4]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

ORG_CITY: SEATTLE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Overall Narrative Novel treatments for opioid addiction will require a better understanding of the functional changes in the neural circuitry controlling motivated behavior. Powerful new genetic and imaging tools enable high resolution visualization in rodents of neurocircuit functions that are affected by opioids. The University of Washington Center of Excellence in Opioid Addiction research will provide a set of resources through its ‘Molecular Genetics Resource Core’ and ‘Imaging and Neural Circuits Core’ designed to facilitate opioid addiction studies by the participating research groups and to support molecular and cellular analyses of neural circuit function at the high temporal and spatial resolution necessary to advance our understanding of addicted brain function.

PI_NAMEs: CHAVKIN, CHARLES  (contact)

PROGRAM_OFFICER_NAME: VEMURI, KIRAN R V

PROJECT_TERMS: addiction;Address;Affect;Animals;Anxiety Disorders;archive data;awake;Award;Behavior;Behavioral;Brain;Brain imaging;Calcium Signaling;Canis familiaris;Cells;Cessation of life;Chronic;Collaborations;Communities;Community Outreach;comorbidity;Complex;computational neuroscience;Computer Analysis;Confocal Microscopy;Coupled;CRISPR/Cas technology;data analysis pipeline;design;design and construction;Development;Disease;Disease remission;drug abstinence;Drug Addiction;Drug usage;dysphoria;Education and Outreach;Educational workshop;Electrophysiology (science);Endoscopy;Ensure;Faculty;Fentanyl;Fiber;Fostering;Gene Expression;Generations;Genetic;genetic manipulation;genetic resource;Genetic Techniques;Goals;graduate student;Heroin;high risk;Image;imaging approach;Imaging Device;Imaging Techniques;in vivo;Infrastructure;innovation;insight;Institution;interest;Investigation;Laboratories;Light;Link;meetings;Mental Depression;Minority;Modernization;Molecular;Molecular Genetics;Monitor;motivated behavior;Mus;National Institute of Drug Abuse;neural circuit;Neurobiology;neuroimaging;Neurons;Neurosciences;North Carolina;novel;novel therapeutics;open data;Opiate Addiction;Opioid;opioid overdose;opioid use;opioid use disorder;optogenetics;outreach;overdose risk;Pain;Participant;Pharmacology;Photometry;Photons;Pilot Projects;post-doctoral training;Postdoctoral Fellow;Productivity;programs;Qualifying;Reagent;Receptor Signaling;Recording of previous events;recruit;Relapse;relapse risk;Reproducibility;Research;Research Personnel;research study;Research Training;Resolution;Resource Sharing;Resources;Risk;Rodent;Rodent Control;Science;Scientist;Self Administration;sensor;summer research;Techniques;tool;Training;Training Programs;Translations;two photon microscopy;two-photon;undergraduate research experience;undergraduate student;Universities;vector;Viral;Viral Genes;virtual;Visit;Visualization;Washington;web site

PROJECT_TITLE: University of Washington Center of Excellence in Opioid Addiction Research

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 SKP-D (M1)]


NIH_SPENDING_CATS: Brain Disorders;Drug Abuse (NIDA only);Opioid Misuse and Addiction;Opioids;Substance Misuse

PROJECT_TERMS: addiction;Address;Advisory Committees;Archives;Biomedical Research;Budgets;Collaborations;Data;Data Analyses;Data Set;Deposition;Development;Drug Addiction;Education and Outreach;Educational workshop;Ensure;Environmental Health;Epidemic;Expenditure;Genetic;Goals;graduate student;High School Student;Historically Black Colleges and Universities;IACUC;Image;interest;Laboratories;meetings;member;Monitor;National Institute of Drug Abuse;neural circuit;Opiate Addiction;opioid use;outreach;Persons;Pilot Projects;Postdoctoral Fellow;programs;Publications;Publishing;Reagent;Reproducibility;Research;Research Personnel;Research Priority;Research Project Grants;Research Support;Resource Sharing;Resources;Safety;Schedule;Science;skill acquisition;student training;Students;Training;training opportunity;Training Programs;Travel;undergraduate student;underrepresented minority student;Underrepresented Populations;Universities;Visit;Vocational Guidance;Washington;web site

PROJECT_TITLE: Administrative Core