NIH_SPENDING_CATS: Bioengineering;Building Research Capacity at Institutions with Limited NIH Funding;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

PI_NAMEs: REDDA, KINFE KEN (contact)

PROJECT_TERMS: Address;Adopted;Affect;Agriculture;Artificial Intelligence;Attenuated;Behavioral;Behavioral Research;Bioinformatics;Biological;Biomedical Research;Biotechnology;Communities;community engagement;Consultations;cytokine;Data;data acquisition;data management;data privacy;Dedications;Disease;drug discovery;Educational workshop;Equipment;Ethics;ethnic minority;experience;Experimental Designs;Extramural Activities;Face;Facility Designs;Florida;Flow Cytometry;Funding;Goals;graduate student;health data;Health Disparities Research;health disparity;high-throughput drug screening;imaging facilities;improved;indexing;innovative technologies;investigator training;Journals;Laboratories;Mechanics;medically underserved population;Methodology;Methods;Minority Groups;minority health;minority health disparity;minority scientist;Mission;molecular modeling;Morbidity - disease rate;mortality;multidisciplinary;multiple omics;National Institute on Minority Health and Health Disparities;Nuclear Magnetic Resonance;Outcomes Research;Pilot Projects;Polishes;Procedures;Process;Productivity;programs;Proteomics;Public Health;Publishing;racial minority;Recycling;remediation;Research;Research Activity;Research Design;research facility;Research Infrastructure;Research Personnel;Research Project Grants;Research Support;Research Training;Resources;Risk Management;Rural;Services;skills;statistics;success;Techniques;Technology;Therapeutic;tool;Training;Training Activity;training opportunity;United States National Institutes of Health;Universities;Writing

PROJECT_TITLE: Research Capacity Core


ADMINISTERING_IC: MD

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: TALLAHASSEE

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: FLORIDA AGRICULTURAL AND MECHANICAL UNIV

ORG_STATE: FL

PI_NAMEs: LEE, EUN SOOK YU (contact)

PROJECT_TERMS: Address;African American;anti-cancer research;Applications Grants;Area;Award;Basic Science;Behavioral;Behavioral Research;Biomedical Research;career;Clinic;community engagement;Comprehensive Cancer Center;Core Facility;cost;Credentialing;Data;Development;disability;Disparity;Disparity population;Economics;Educational workshop;Ensure;Environment;ethnic minority population;Ethnic Origin;Ethnic Population;Evaluation;experience;Extramural Activities;Faculty;Florida;Funding;Goals;Grant;Health;Health Disparities Research;health disparity;health inequalities;Health Services Accessibility;Health Status;Hispanic;improved;indexing;Individual;innovation;interest;Journals;K-Series Research Career Programs;Knowledge;Mainstreaming;medically underserved;Mentors;Methodology;Minority;minority health;minority health disparity;minority scientist;Monitor;Native Americans;novel;Oral;Outcome;Outcomes Research;Pilot Projects;Population;Postdoctoral Fellow;Procedures;Process;Program Development;programs;Publishing;Qualifying;Quality of Care;Race;racial minority population;racial population;recruit;Research;Research Personnel;Research Project Grants;Research Support;Resources;Scientist;Secure;Series;skills;socioeconomics;Solid;Structure;success;Technology;Training;Translational Research;underserved community;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Investigator Development Core


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Cervical Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Lung Cancer;Machine Learning and Artificial Intelligence;Nutrition;Patient Safety;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Women's Health Research

PI_NAMEs: SUTHER, SANDRA G (contact)

PROJECT_TERMS: Address;Adoption;Advocacy;Affect;African American;African American population;African American Women;anti-cancer research;Artificial Intelligence;Beauty;Behavior;Bioethics;black men;Black Populations;black women;cancer clinical trial;cancer education;cancer health disparity;cancer prevention;cancer risk;cancer type;Capital;Censuses;Cervical Cancer Screening;Chronic Disease;Clinical Trials;Collaborations;Communities;community collaboration;community engagement;community organizations;Community Outreach;Community Participation;community partners;Complex;County;Death Rate;Depressed mood;Diagnosis;Disparity;drug discovery;Drug Interactions;Early Diagnosis;early screening;economic disparity;education research;education resources;Educational Activities;Environment;Equity;Ethnic Population;Event;evidence base;Faith;Family;Florida;Focus Groups;Food;Fruit;General Population;Geographic Locations;Goals;Hair;Health;Health Disparities Research;Health Fairs;health inequalities;health literacy;Health Promotion;Health Services Accessibility;Healthcare;Healthcare Systems;healthy lifestyle;Heavy Drinking;Herb;hispanic community;Hispanic Women;Home;improved;Incidence;Individual;Inequality;Inequity;Knowledge;Longevity;Malignant Breast Neoplasm;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Measures;medication safety;member;men;minority communities;Minority Groups;Mission;mortality;Names;nutrition;nutrition education;Outcome;outreach;Pamphlets;Participant;patient oriented;Persons;physical inactivity;Population;Population Group;prevent;Quality of life;racial population;Research;Research Personnel;Research Project Grants;research study;Resources;rural counties;Saliva;Sampling;satisfaction;Science;Scientist;screening;Screening for cancer;Services;skills;social;social disparities;socioeconomics;State Government;Students;Surveys;Tobacco use;Training;underserved minority;Underserved Population;United States;Universities;Vegetables;Voice;volunteer;webinar;Weight

PROJECT_TITLE: Community Engagement Core


NIH_SPENDING_CATS: Breast Cancer;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Estrogen;Genetics;Social Determinants of Health;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Women's Health Research

PI_NAMEs: TILGHMAN, SYREETA L (contact)

PROJECT_TERMS: 3-Dimensional;Apoptosis;Aromatase Inhibitors;Basic Research Breast Cancer;Biology;Breast Cancer Cell;Cancer Biology;Cancer Prognosis;cancer stem cell;Cell Cycle;Cell Cycle Progression;Cell Proliferation;Cells;Clinical;Critical Pathways;Data;Death Rate;Development;Disease;DNA Damage;Emergency Department patient;Endocrine;Equilibrium;ESR1 gene;Estrogen receptor positive;Estrogens;expectation;Foundations;Genetic;genetic signature;Genetic Transcription;Genomic Instability;Goals;Growth;Health Disparities Research;hormone sensitivity;hormone therapy;Hormones;improved;In Vitro;in vivo;inhibitor;innovation;knock-down;Knowledge;Letrozole;Ligand Binding Domain;Malignant Breast Neoplasm;Mammospheres;MCF7 cell;Measures;Modality;Molecular Chaperones;Motility;Mutation;Neoplasm Metastasis;novel;novel marker;novel strategies;novel therapeutics;Nuclear Export;Outcome;overexpression;Pathway interactions;pharmacologic;Phenotype;Point Mutation;prevent;programs;Proliferating;Proteins;Proteomics;Publishing;recruit;Refractory;Refractory Disease;Relapse;Research;Research Personnel;Research Project Grants;Resistance;Resistance development;Ribosomes;Role;screening;Selective Estrogen Receptor Modulators;Series;stemness;synergism;targeted treatment;Testing;Therapeutic;therapy outcome;tissue/cell culture;transcriptional reprogramming;treatment strategy;tumor;two-dimensional;vector;Woman;Work

PROJECT_TITLE: Research Project-1: Midasin, A Novel Biomarker for Endocrine Resistant Breast Cancer


NIH_SPENDING_CATS: Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Chronic Pain;Neurodegenerative;Neurosciences;Opioids;Pain Research;Peripheral Neuropathy;Social Determinants of Health

PI_NAMEs: ABLORDEPPEY, SETH Y (contact)

PROJECT_TERMS: abuse liability;addiction;Address;Affinity;Agonist;Alcohol abuse;Analgesics;analog;antagonist;antinociception;beta-arrestin;Binding;Biological Availability;Brain;Brain region;Central Nervous System Diseases;Characteristics;chronic neuropathic pain;clinical candidate;Cognition;Collaborations;cytotoxic;cytotoxicity;design;Development;Drug abuse;effective therapy;efficacy evaluation;enantiomer;endogenous opioids;Environment;Evaluation;evaluation/testing;Functional disorder;functional group;General Population;Goals;GTP-Binding Proteins;Health Disparities Research;Hepatocyte;HepG2;Hydroxylation;Hyperalgesia;improved;In Vitro;in vivo;Inflammatory;Laboratories;Lead;lead optimization;Ligands;Literature;Mechanical Stimulation;Memory;Metabolic;metabolic profile;Metabolism;neurochemistry;New Agents;Opioid;Opioid Analgesics;Oral;Pain;pain behavior;Pain Measurement;pain sensation;painful neuropathy;Paper;Pathology;Pathway interactions;Penetration;Permeability;Pharmaceutical Preparations;pharmacokinetic characteristic;pharmacologic;Pharmacologic Actions;Pharmacology;prevent;process optimization;protein-tyrosine kinase c-src;Psychotropic Drugs;receptor;recruit;Reporting;Research Project Grants;response;Rodent;Role;scaffold;screening program;Sequence Homology;serotonin 7 receptor;side effect;Signal Pathway;Signal Transduction;Sleep Disorders;System;Testing;Tetrahydroisoquinolines;Texas;Therapeutic;therapeutic evaluation;United States National Institutes of Health;Universities

PROJECT_TITLE: Research Project-2: Functionally Selective Ligands Targeting 5-HT7 Receptor as Potential Antinociceptive Agents


NIH_SPENDING_CATS: Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Cervical Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Networking and Information Technology R&D (NITRD);Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health;Telehealth;Women's Health Research

PI_NAMEs: LUQUE, JOHN S. (contact)

PROJECT_TERMS: Address;Adherence;Adult;Affect;attentional control;Attitude;barrier to care;Behavior;Belief;cancer education;cancer health disparity;cancer prevention;cervical cancer prevention;Cervical Cancer Screening;Child Care;Clinic;Communities;community academic partnership;community engagement;Community Health Aides;community intervention;community partnership;community research;comparison intervention;Control Groups;cost effective;Cost Effectiveness Analysis;cost estimate;cost-effectiveness ratio;Counseling;Death Rate;design;Development;Diagnosis;digital;Disparity;Education;education research;Educational Intervention;Effectiveness;Effectiveness of Interventions;effectiveness testing;eHealth;Evaluation;evidence base;Exclusion;Florida;follow-up;Follow-Up Studies;Fright;Future;Goals;group intervention;Health;health care availability;Health Disparities Research;health disparity;health disparity populations;Health Insurance;Healthcare;Hispanic;Hispanic Populations;Hispanic Women;Hour;Human Papillomavirus;Immigrant;Immigration;improved;Incidence;incremental cost-effectiveness;Individual;innovation;Intervention;intervention refinement;Intervention Studies;Knowledge;Language;Latino Population;Link;Malignant neoplasm of cervix uteri;Media Intervention;Not Hispanic or Latino;nutrition education;Outcome;Pamphlets;Participant;peer;perceived discrimination;personalized approach;Policies;Population;post intervention;Prevention program;programs;Puerto Rican;Randomized, Controlled Trials;Recommendation;Reporting;Research;Research Infrastructure;Research Project Grants;Research Project Summaries;risk perception;rural setting;Sampling;screening;Screening for cancer;screening guidelines;Self Efficacy;Series;Site;Slide;social stigma;Southeastern United States;Spanish;Telephone;Testing;theories;Time;Transportation;transportation access;treatment as usual;trial design;Uninsured;Update;uptake;White Women;Woman;Work

PROJECT_TITLE: Research Project-3: Effectiveness of an eHealth intervention for uptake of cervical cancer screening in Hispanic women


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering

ORG_CITY: CHICAGO

ORG_DEPT: PHYSICS

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE A fundamental challenge in modern cell biology is to understand how cells sense and process mechanical signals to alter their physiology. We propose a multi-disciplinary strategy to reveal the mechanism by which LIM domain proteins control mechanotransduction pathways in epithelial tissue. These experiments will elucidate the mechanism by which LIM domains bind to mechanically stressed actin filaments, the force-dependent sorting of LIM proteins to within adherent cells and control ofYAP/TAZ. mechanotransduction signaling by the LIM protein LIMD1 in epithelia.

PI_NAMEs: GARDEL, MARGARET LISE (contact)

PROGRAM_OFFICER_NAME: RIGAS, MARC

PROJECT_TERMS: Actins;Atherosclerosis;Binding;Biochemistry;Biophysics;cell behavior;Cell Physiology;Cells;Cellular biology;Communication;Cytoskeleton;Defect;Disease;Environment;Epithelium;Exhibits;experimental study;Heart failure;innovation;instrument;LIM Domain;LIM Domain Protein;live cell imaging;Malignant Neoplasms;mathematical model;mechanical force;mechanical signal;mechanical stimulus;Mechanical Stress;Mechanics;mechanotransduction;Methodology;Microfilaments;Modernization;Molecular;Movement;multidisciplinary;novel strategies;organ regeneration;Pathway interactions;Physiological;Physiology;Process;Protein Family;Proteins;recruit;Shapes;Signal Transduction;Sorting;Specificity;Tissues;transmission process

PROJECT_TITLE: Instrument Supplement: Mechanisms of Mechanotransduction by LIM Domain Proteins

STUDY_SECTION_NAME: Cell Structure and Function 1 Study Section[CSF1]


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Genetics;Human Genome;Neurosciences;Prevention;Substance Misuse

ORG_CITY: PITTSBURGH

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project Narrative Substance use disorders affect more than 100 million people worldwide and are influenced by the genetic makeup of the individual, in humans as well as rodent models. In this proposal, I will investigate how genetic differences in humans and mice could influence sets of brain cell types shared across human, monkey, and rodents. These results will provide a foundation to link the power of rodent models to specific features of SUDs in humans.

PI_NAMEs: PHAN, BADOI NGUYEN (contact)

PROGRAM_OFFICER_NAME: LIN, YU

PROJECT_TERMS: addiction;Affect;Alcohol consumption;Alcohols;Animals;Area;ATAC-seq;Atlases;Automobile Driving;Autopsy;base;Behavior;Brain;brain cell;Brain region;brain tissue;Cannabis;Cell Nucleus;cell type;Cells;Chromatin;Clinical;Clinical Research;Collaborations;Communities;Comparative Genomic Analysis;comparative genomics;Complex;Corpus striatum structure;Data;Development;Dopamine D1 Receptor;Dorsal;Drug Addiction;Enhancers;Epigenetic Process;epigenomics;experience;experimental study;Fellowship;Foundations;Future;Gene Expression Profile;Genes;Genetic;genetic makeup;Genetic Markers;Genetic Variation;Genome;genome wide association study;genomic data;Heritability;Human;human disease;Human Genetics;Individual;insight;interest;leadership development;Letters;Link;Macaca;Machine Learning;machine learning algorithm;mammalian genome;Maps;Medicine;Mentors;model organism;Modeling;Molecular;Monkeys;mouse genetics;Mus;neural circuit;neurobehavioral;Neurons;neuropsychiatry;Nicotine;nonhuman primate;novel;Nucleus Accumbens;personalized medicine;Persons;Pharmaceutical Preparations;Phenotype;Physicians;pre-clinical research;Predisposition;prevent;Primates;programs;Quantitative Trait Loci;Rattus;Research;Research Training;Resolution;Rewards;Risk;Risk Behaviors;risk variant;Rodent;Rodent Model;Scientist;single cell genomics;single nucleus RNA-sequencing;skills;Specificity;Speed;Substance Addiction;substance use;Substance Use Disorder;System;Testing;Training;trait;transcriptomics;Variant;Work

PROJECT_TITLE: Integrating primate-rodent cell types and epigenomics to identify conservation in substance addiction

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F08-M(20)L]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Radiation Oncology

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: The proposed activities will enhance the incorporation of patient-reported outcomes into national clinical trials, both through supporting the incorporation of patient-reported outcomes in protocols in development and through the development of my own trial concept through ECOG-ACRIN’s Cancer Care Delivery Research Committee. This work will increase our ability to include patient voices into the interpretation of clinical trials, improving our ability to engage in shared decision-making with cancer patients.

PI_NAMEs: PLATANIAS, LEONIDAS C. (contact)

PROGRAM_OFFICER_NAME: PTAK, KRZYSZTOF

PROJECT_TERMS: American College of Radiology Imaging Network;Award;cancer care;Cancer Patient;care delivery;career;Clinic;Clinical Investigator Award;Clinical Research;Clinical Trials;Collaborations;design;Development;Eastern Cooperative Oncology Group;improved;Institution;Malignant Neoplasms;Methodology;multidisciplinary;Patient Outcomes Assessments;Patients;programs;prospective;Protocols documentation;Radiation Oncologist;Research;shared decision making;Surveys;Training;Treatment-related toxicity;Voice;Work

PROJECT_TITLE: Early Career Cancer Clinical Investigator Award for Fiscal Year (FY) 2024


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Health Services;Mental Health;Mental Illness;Neurosciences;Pediatric

ORG_CITY: Los Angeles

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

ORG_STATE: CA

PHR: PROJECT NARRATIVE Up to 42% of children experience dental fear and anxiety (DFA), which predicts negative behaviors in the clinic, irregular appointment attendance, need for general anesthesia, and poor oral health and oral health- related quality of life. This proposed study, which is based on promising pilot results, will be the first full-scale randomized clinical trial of a sensory adapted intervention to modify the dental environment in treating typically developing children. If successful, the intervention has the potential to improve clinic-based dental care for countless children who are prone to experiencing physiological anxiety, behavioral distress, and pain in the dental clinic.

PI_NAMEs: STEIN DUKER, LEAH I. (contact)

PROGRAM_OFFICER_NAME: MATTIA, JILL

PROJECT_TERMS: acceptability and feasibility;aged;Anxiety;anxiety reduction;anxious;Appointment;arm;Auditory;autistic children;Behavior;Behavioral;Caring;Child;Child Behavior;Child Care;Childhood;Clinic;Clinical Trials;Consumer Satisfaction;Dental;Dental Anxiety;Dental Care;Dental Clinics;Dentists;Distress;effectiveness trial;Elements;Environment;ethnic diversity;Exhibits;experience;Fluorides;Fright;Funding;Galvanic Skin Response;General Anesthesia;Goals;health related quality of life;improved;innovation;Intervention;intervention cost;intervention effect;Los Angeles;Mediating;Mediator;Methodology;Modeling;Modification;National Institute of Dental and Craniofacial Research;Noise;novel;Oral;oral care;Oral cavity;Oral Examination;Oral health;Outcome;Pain;Participant;Pediatric Hospitals;Phase;Physiological;Pilot Projects;Population;primary outcome;procedure cost;Procedures;Prophylactic treatment;Protocols documentation;Quality of Care;Randomized;randomized, clinical trials;Reaction;recruit;Research;Research Design;response;Risk Factors;Role;Root Canal Therapy;satisfaction;secondary analysis;secondary outcome;Sedation procedure;Sensory;sensory stimulus;Services;Site;Smell Perception;social observations;sound;Tactile;Taste Perception;Techniques;Testing;Touch sensation;Treatment Efficacy;trial planning;U-Series Cooperative Agreements;video delivery;Visual;Well in self;Work

PROJECT_TITLE: Sensory Adapted Dental Environments to Enhance Oral Care for Children with and without Dental Fear and Anxiety


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Lung;Neurosciences

ORG_CITY: STORRS-MANSFIELD

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF CONNECTICUT STORRS

ORG_STATE: CT

PHR: Project Narrative In the past several years, important progress has been made in identifying genes implicated in neurodevelopmental disorders. It is now recognized that KCNQ2 loss and gain of function mutations lead to developmental epileptic encephalopathy that might also include respiratory dysfunction and severe central hypoventilation syndrome. Therefore, the goal of this application is to understand the essential role of KCNQ2 in control of breathing that may explain both the origins and developmental progression of symptoms, as well as to propose strategies for effective therapeutic interventions.

PI_NAMEs: MULKEY, DANIEL K (contact);TZINGOUNIS, ANASTASIOS

PROGRAM_OFFICER_NAME: LAPOSKY, AARON D

PROJECT_TERMS: Affect;Animals;autism spectrum disorder;Binding;Brain;Breathing;Carbon Dioxide;Cell Nucleus;Chemoreceptors;Chronic;cofactor;Coupled;Development;developmental epileptic encephalopathy;Electrophysiology (science);epileptic encephalopathies;Foundations;gain of function;gain of function mutation;Genes;genetic manipulation;Goals;Hydrolysis;Hypoventilation;improved;knock-down;Lead;Link;loss of function;Mediating;Modeling;Mus;Mutation;Myoclonus;myoinositol;neonatal brain;neural;Neurodevelopmental Disorder;Neurons;Neurotransmitters;novel;parent grant;Patients;pharmacologic;Phosphatidylinositol 4,5-Diphosphate;Phosphatidylinositols;Potassium Channel;Production;Property;receptor;Recurrence;Reflex action;Regulation;Research;Respiration Disorders;respiratory;Respiratory Center;response;Role;Signal Transduction;Slice;symporter;Symptoms;Synapses;Syndrome;Testing;Therapeutic Intervention;therapeutic target;therapeutically effective;Tissues;Variant;Viral;Work

PROJECT_TITLE: Role of KCNQ2 Channels in Control of Breathing

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Drug Abuse (NIDA only);Mental Health;Mental Illness;Opioid Misuse and Addiction;Opioids;Pain Research;Prevention;Screening and Brief Intervention for Substance Misuse;Substance Misuse

ORG_CITY: Columbus

ORG_DEPT: PSYCHIATRY

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE Heavy, problematic alcohol use is highly prevalent within individuals receiving medication for opioid use disorder (MOUD) and contributes to increased risk of opioid overdose and poorer OUD treatment outcomes. Emerging research suggests that two individual difference factors that interact to amplify the negative reinforcement cycle of addiction and facilitate alcohol use during MOUD are anxiety sensitivity (AS) and intolerance of uncertainty (IU). The goal of the current study is to refine and adapt a brief digitally-enhanced, psychotherapeutic intervention that targets AS and IU for heavy alcohol users engaged in MOUD and explore how changes in AS/IU targets are related to changes in heavy drinking and medication adherence to inform a large-scale mechanistic clinical trial.

PI_NAMEs: ALLAN, NICHOLAS PAUL;GORKA, STEPHANIE  (contact)

PROGRAM_OFFICER_NAME: WANG, JIA BEI

PROJECT_TERMS: Academic Medical Centers;active control;addiction;Adherence;Alcohol abuse;Alcohol consumption;alcohol measurement;alcohol use disorder;Alcohols;Anxiety;anxiety sensitivity;arm;Arousal;Blinking;bodily sensation;brief intervention;Cellular Phone;Chemosensitization;Clinical Trials;Cognitive Therapy;community partners;Consensus;coping;craving;Data;Development;digital;digital technology;digital tool;Disease;Distress;drinking;drinking behavior;Ecological momentary assessment;Electroencephalography;Emotional;emotional experience;Emotions;Event-Related Potentials;Exhibits;Expectancy;General Population;Goals;Health Professional;Health Promotion;Heavy Drinking;implementation protocol;Implementation readiness;Individual;Individual Differences;Infrastructure;insight;Intervention;Link;Measures;medication compliance;medication for opioid use disorder;Mental Health;Methods;mobile application;Modeling;modifiable risk;multimodality;negative affect;Negative Reinforcements;Opioid;opioid overdose;opioid use;opioid use disorder;Outcome;Outcome Study;Outpatients;Pain;Participant;Pathway interactions;Patient Self-Report;Patients;Perception;personalized medicine;Phase;Play;Probability;Process;Protocols documentation;psychological distress;Randomized, Controlled Trials;Reaction;reduced alcohol use;Research;Risk;Risk Factors;Role;Self Medication;Standardization;Stimulus;stressor;substance use;Surveys;theories;treatment center;Treatment outcome;Uncertainty;Universities;university student;usability;virtual;Withdrawal

PROJECT_TITLE: Brief Digitally-Enhanced Intervention for Managing Emotional Pain and Reducing Alcohol Use during Medication for OUD

STUDY_SECTION_NAME: Special Emphasis Panel[ZAA1 DD (06)]


NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: DAVIS

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Narrative Concerns of permanent undesirable off-target DNA edits has hampered acceptance of genomic editing tools to treat genetic disorders. The long-term goal of this proposal aims to treat these disorders by selectively editing the RNA transcripts to produce functional protein. Guide oligonucleotides will be screened and optimized to target mRNA mutations that can be repaired by the cell’s RNA editing enzymes.

PI_NAMEs: FISHER, ANDREW J (contact)

PROGRAM_OFFICER_NAME: SIMONOVIC, MILJAN

PROJECT_TERMS: ADAR1;Adenosine;Binding;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Code;Codon Nucleotides;Complex;Cryoelectron Microscopy;Deamination;design;Disease;DNA;Double-Stranded RNA;DRADA2b protein;dsRNA adenosine deaminase;Enzymes;experience;Genetic Diseases;genome editing;Goals;Guanosine;Guide RNA;high throughput screening;improved;Inosine;Knowledge;Lead;Length;Messenger RNA;Metabolic;Methods;Mutation;Nonsense Mutation;nucleobase;nucleotide analog;Oligonucleotides;Point Mutation;Proteins;rational design;Reaction;repaired;Resolution;RNA;RNA Editing;Site;Structure;Techniques;Terminator Codon;tool;Transcript;Translations;X-Ray Crystallography

PROJECT_TITLE: Supplement: High-throughput screening and structure-guided optimization of oligonucleotides for site-directed RNA editing by ADARs.

STUDY_SECTION: SBCB

STUDY_SECTION_NAME: Synthetic and Biological Chemistry B Study Section[SBCB]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Cervical Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;HIV/AIDS;HPV and/or Cervical Cancer Vaccines;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Immunization;Infectious Diseases;Pediatric;Pediatric - AIDS;Prevention;Primary Health Care;Sexually Transmitted Infections;Social Determinants of Health;Vaccine Related;Women's Health Research

ORG_CITY: NEW YORK

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: NEW YORK UNIVERSITY

ORG_STATE: NY

PHR: Public Health Relevance Cervical cancer burden represents a major global health disparity, and women living with HIV are particularly affected. High coverage of HPV vaccine will be necessary to substantially reduce incidence and ultimately achieve cervical cancer elimination in high-burden settings like Eastern Africa; however, uptake of the HPV vaccine in the region is low despite national programs that offer HPV vaccine for free to preadolescent girls. This study will identify optimized implementation strategies – effective, implementable, and sustainable – for increasing clinician recommendation of HPV vaccination for girls and young women living with HIV in Malawi; these findings will have immediate relevance in Malawi, the country with the second-highest cervical cancer burden globally, and for other low-resource settings struggling to achieve high HPV vaccine coverage.

PI_NAMEs: HOFFMAN, RISA M.;MOUCHERAUD, CORRINA  (contact);PHIRI, SAM

PROGRAM_OFFICER_NAME: ALARO, JAMES R

PROJECT_TERMS: Acceleration;Adoption;Affect;African;Age;aged;Attention;Behavioral;Cancer Burden;Cancer Control;Caring;Cessation of life;Clinical;cost;Cost Measures;Country;Decision Making;design;Dose;Drug Prescriptions;Eastern Africa;Effectiveness;Eligibility Determination;Evidence based intervention;Experimental Designs;Female Adolescents;fighting;Focus Groups;girls;global health;Health;Health care facility;health disparity;Health Personnel;Health system;high risk;HIV;HPV vaccine acceptance;Human Papilloma Virus Vaccination;Human Papilloma Virus Vaccine;Immunization Programs;implementation cost;implementation science;implementation strategy;improved;Incidence;Income;innovation;insight;Institution;Intervention;Knowledge;Life;low and middle-income countries;low income country;Malawi;Malignant neoplasm of cervix uteri;Measures;Medical Records;Memory;multidisciplinary;multiphase optimization strategy;Nurses;Parents;Performance;Phase;pilot test;Policies;preadolescence;prevent;primary outcome;Process;programs;Provider;provider adoption;public health relevance;Qualifying;Randomized;Recommendation;Research;Research Personnel;Resource-limited setting;Resources;scale up;screening services;secondary outcome;Site;skills;social;Subgroup;Surveys;System;Testing;Theoretical Domains framework;therapy design;therapy development;Time;Training;translational framework;treatment services;Update;uptake;Vaccination;vaccine acceptance;vaccine hesitancy;Visit;Woman;Work;World Health Organization;young woman

PROJECT_TITLE: Kupewa: Optimizing strategies to implement provider recommendation of HPV vaccination for adolescent girls and young women with HIV in Malawi

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 RPRB-M (M2)]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Cervical Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;HIV/AIDS;Health Services;Infectious Diseases;Prevention;Primary Health Care;Sexually Transmitted Infections;Women's Health Research

ORG_CITY: WACO

ORG_NAME: BAYLOR UNIVERSITY

ORG_STATE: TX

PHR: PROJECT NARRATIVE Evidence-based HPV self-sampling coupled with the 3R (reframe, reprioritize, and reform) communication model increases cervical cancer screening and is effective in minimizing the cervical cancer burden among women living with HIV (WLWH) in Ghana. Implementation strategies to translate the efficacy of HPV self-sampling and 3R model into women’s healthcare in Ghana are needed. We propose to develop and adapt implementation strategies to maximize the success of the HPV self-sampling and 3R model in increasing its health system adoption, patient uptake, and the sustainment of cervical cancer screening among WLWH.

PI_NAMEs: ASARE, MATTHEW  (contact);OBIRI-YEBOAH, DORCAS ;SAM-AGUDU, NADIA A.

PROJECT_TERMS: 2 arm randomized control trial;Acquired Immunodeficiency Syndrome;Address;Adoption;arm;Behavior;Behavioral;Cancer Burden;cervical cancer prevention;Cervical Cancer Screening;Clinic;Clinical;Collaborations;Communication;Communities;Control Groups;cost;Cost Analysis;Country;Coupled;Data;Effectiveness;effectiveness evaluation;effectiveness research;effectiveness-implementation RCT;effectiveness/implementation study;effectiveness/implementation trial;efficacy study;Eligibility Determination;Enrollment;Evaluation;evidence base;Exploration, Preparation, Implementation, and Sustainment;Family;Feedback;Funding;Ghana;group intervention;Health care facility;Health Personnel;Health system;Healthcare;High Prevalence;HIV;Home;Hospitals;HPV-High Risk;Human Papillomavirus;hybrid type 2 trial;Hybrids;implementation intervention;implementation measures;implementation outcomes;implementation research;implementation strategy;implementation/effectiveness;Indigenous;Individual;Infrastructure;innovation;interest;Intervention;Interview;Leadership;low and middle-income countries;Malignant neoplasm of cervix uteri;Measurement;medically underserved;Methods;Modeling;Outcome;Participant;participant enrollment;Patient Representative;Patients;Penetration;Phase;Population;Preparation;Prevention education;primary outcome;programs;Provider;Randomized;Randomized, Controlled Trials;recruit;Reporting;Research;research to practice;Resources;response;Risk;routine practice;Sampling;scale up;screening;Screening for cancer;Self Efficacy;Sensitivity and Specificity;Site;Social support;success;Surveys;System;Teaching Hospitals;Techniques;Testing;Training;Translating;Translations;two-arm trial;uptake;Variant;Woman;Women's Health

PROJECT_TITLE: The Impact of an Evidence-Based, Behavioral Cervical Cancer Screening Intervention among Women Living with HIV in Ghana (HOPE-inG): A Type 2 Hybrid Effectiveness Implementation Trial


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Patient Safety

ORG_CITY: PHILADELPHIA

ORG_NAME: THOMAS JEFFERSON UNIVERSITY

PHR: Narrative The Lead Academic Participating Site (LAPS) funding opportunity is intended to provide infrastructure support for the conduct of national clinical trials through the National Clinical Trials Network (NCTN). The overall objective and goal of this proposal is to enable SKCC to participate as a Lead Academic Participating Site (LAPS) in the NCI National Clinical Trial Network (NCTN) Clinical Research Program. This goal will be achieved through providing scientific leadership for development and execution of NCTN trials complemented by an integrated and collaborative research program.

PI_NAMEs: COHEN, STEVEN ;JOHNSON, JENNIFER  (contact);SCHILDER, RUSSELL J;SHAHIN, MARK ;WERNER-WASIK, MARIA

PROGRAM_OFFICER_NAME: MOONEY, MARGARET M

PROJECT_TERMS: Address;Advanced Malignant Neoplasm;American College of Radiology Imaging Network;Basic Science;bench to bedside;Cancer Biology;cancer care;Cancer Center;career development;Catchment Area;Characteristics;Cities;Clinical assessments;Clinical Research;Clinical Trials;Clinical Trials Network;Collaborations;Communities;community engagement;County;data quality;Delaware;design;Discipline;Eastern Cooperative Oncology Group;Education;Faculty;Fostering;Funding Opportunities;Goals;Health;health equity;Health system;Hospitals;Incidence;Industry;Infrastructure;innovation;Institution;Knowledge;Laboratories;Laboratory Research;Lead;Leadership;leadership development;Malignant Neoplasms;member;mortality;National Clinical Trials Network;NCI Center for Cancer Research;NCI-Designated Cancer Center;New Jersey;Oncology;Oncology Group;outreach;Outreach Research;Participant;Patients;Pennsylvania;performance site;Philadelphia;population based;Population Heterogeneity;Population Research;Positioning Attribute;Process;programs;Protocols documentation;Race;Radiation Therapy Oncology Group;rare cancer;Research;Research Personnel;Research Priority;research study;Role;Shapes;Site;socioeconomics;symptom management;System;Technology;Time;Translational Research;Underserved Population;United States National Institutes of Health

PROJECT_TITLE: Sidney Kimmel Cancer Center LAPS Institutional Collaboration


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Genetics

ORG_CITY: SAINT LOUIS

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Nucleoli are the cellular centers of ribosome biogenesis, and disruptions to nucleolar proteins cause inherited ribosomopathies and contribute to proliferative diseases like cancer and degenerative diseases like muscular dystrophy. I propose to determine a quantitative and predictive mechanism of the assembly-line-like handoff of newly synthesized mature ribosomal RNA that leads to ribosome biogenesis. This knowledge will advance our fundamental understanding of nucleolar physiology and can be leveraged to generate therapeutics to treat this process, which remains untargeted clinically.

PI_NAMEs: KING, MATTHEW R (contact)

PROGRAM_OFFICER_NAME: TAYLOR, VERONICA

PROJECT_TERMS: Architecture;Binding;Biochemical;Biogenesis;Bioinformatics;biophysical properties;Biophysics;cell growth;Cell Nucleolus;Clinical;Complex;Computer Models;Coupled;Data;Degenerative Disorder;density;Disease;Electron Microscopy;Equilibrium;Genetic Transcription;Goals;Grain;In Vitro;in vivo;Inherited;Investigation;Knowledge;Lead;Life;Link;Literature;Malignant Neoplasms;Mandibulofacial Dysostosis;Measures;Mediating;Membrane;Methods;Microscopy;Modeling;Molecular;molecular scale;Muscular Dystrophies;Names;Nature;new therapeutic target;Nucleic Acids;Nucleolar Proteins;nucleolin;nucleophosmin;Organelles;Phase;Physiology;Play;Process;Production;Proteins;reconstitution;Ribosomal Proteins;Ribosomal RNA;Ribosomes;ribosomopathy;RNA;RNA Splicing;Role;Series;Set protein;Structure;System;Testing;Therapeutic;therapeutic target;Thermodynamics;Work

PROJECT_TITLE: Uncovering mechanisms of rRNA flux through the nucleolus


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: NEW HAVEN

ORG_DEPT: NEUROLOGY

ORG_NAME: YALE UNIVERSITY

PHR: Through comprehensive analyses of brain proteomic data, we recently identified the ERK signaling pathway, specifically within microglia, as a central feature of Alzheimer's disease (AD) and a likely pathogenic mechanism. In this proposal, we will use a novel cell type-specific in-vivo proteomic labeling approach together with drugging and gene deletion studies to systematically define the distinctive roles of ERK signaling within neurons and microglia on AD pathogenesis. If successful, our studies will lead to identifying novel treatment targets and biomarkers for AD.

PI_NAMEs: RANGARAJU, SRIKANT  (contact);SEYFRIED, NICHOLAS THOMAS;WOOD, LEVI BENJAMIN

PROGRAM_OFFICER_NAME: YANG, AUSTIN JYAN-YU

PROJECT_TERMS: Age;Aging;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer’s disease biomarker;Amyloid beta-Protein;asymptomatic Alzheimer's disease;attenuation;Autopsy;Behavioral;Biological;Biological Markers;biomarker discovery;Biotin;Biotinylation;BRAF gene;Brain;brain cell;brain control;Cell Separation;cell type;Cells;Cerebrospinal Fluid;Characteristics;Coupled;cytokine;Data;Dementia;Disease;Disease associated microglia;Dominant-Negative Mutation;Dose;Evolution;Exhibits;Family;Gene Deletion;Gene Expression;genetic approach;genetic manipulation;Human;Impaired cognition;In Vitro;in vivo;Individual;inducible Cre;Inflammatory;Inflammatory Response;inhibitor;innovation;interest;Knock-in Mouse;Label;Ligase;LoxP-flanked allele;MAP2K1 gene;MAPK1 gene;MAPK3 gene;Maps;Mass Spectrum Analysis;Measures;Mediating;MEKs;member;Microglia;Mitogen-Activated Protein Kinases;mouse model;Mouse Protein;multidisciplinary;Mus;Nerve Degeneration;Neurodegenerative Disorders;neuroinflammation;Neurons;neuropathology;new technology;novel;novel strategies;Pathogenesis;Pathogenicity;Pathologic;Pathology;Pathway interactions;Pharmaceutical Preparations;Pharmacogenetics;Phenotype;Phosphoproteins;Phosphorylation;Physiological;Plasma;Play;Positioning Attribute;Predisposition;Proliferating;Protein Secretion;Proteins;Proteome;proteomic signature;Proteomics;Resolution;response;Role;sex;Signal Pathway;Signal Transduction;small molecule;small molecule inhibitor;spatiotemporal;Synaptic plasticity;Systems Biology;Testing;Therapeutic;Tissues;Toxic effect

PROJECT_TITLE: Neuron and microglia-specific proteomic signatures of ERK mediated mechanisms of Alzheimer's disease.


ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE/RELEVANCE To reduce the impact of cancer on people by uniting a broad community of scientists and clinicians from many disciplines, committed to discovering, validating and disseminating effective strategies for the prevention and treatment of cancer.

PI_NAMEs: GALANIS, EVANTHIA ;HAHN, OLWEN ;PIANTADOSI, STEVEN  (contact)

PROJECT_TERMS: Biological;Breast;cancer clinical trial;Cancer Control;cancer therapy;Central Nervous System;clinical practice;Clinical Research;Clinical Trials;Clinical Trials Cooperative Group;Communities;community setting;Consensus;control trial;Discipline;experience;gastrointestinal;Genitourinary system;Hematologic Neoplasms;Infrastructure;innovation;Institution;Malignant Neoplasms;member;Mission;multidisciplinary;Oncology;operation;Patients;Persons;Prevention strategy;Prevention trial;Process;rare cancer;Reporting;Research;respiratory;response;Scientist;Translational Research;treatment trial;Validation

PROJECT_TITLE: Alliance for Clinical Trials in Oncology Operations Center - GY11 BIQSFP Supplements


ADMINISTERING_IC: NS

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Estrogen;Genetics;Machine Learning and Artificial Intelligence;Neurosciences;Prevention;Women's Health Research

ORG_CITY: SANTA BARBARA

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF CALIFORNIA SANTA BARBARA

PHR: Project Narrative Mammalian cognition is fundamentally shaped by steroid hormones, which in turn have major effects on neurological disorders such as epilepsy, schizophrenia, and Alzheimer’s disease, the underlying mechanisms of which remain poorly understood. To address the mechanistic action of hormones in the brain, we will use novel multiphoton imaging, viral gene editing, and ethological behavioral analysis to determine how cyclic endocrine fluctuations across the estrous cycle modulate hippocampal and olfactory plasticity. These results will provide critical insight into the role of steroid hormones in memory function and improve our understanding of sex-specific contributions to neurological disease.

PI_NAMEs: WOLCOTT, NORA SEEMAN (contact)

PROGRAM_OFFICER_NAME: ULLRICH, LAUREN ELIZABETH

PROJECT_TERMS: 3-Dimensional;Address;Affect;Algorithms;Alzheimer's Disease;Apical;Automobile Driving;Award;Behavior;Behavioral;Brain;Calcium;calcium indicator;Cells;Code;Cognition;Computational Technique;Computer Analysis;Coupled;CRISPR/Cas technology;Cues;Data;deep learning;Dendrites;Dendritic Spines;density;Development;early detection biomarkers;Endocrine;Endocrinology;entorhinal cortex;Environment;Epilepsy;Estradiol;Estrogen Receptors;Estrous Cycle;Estrus;Ethology;Etiology;Evaluation;excitatory neuron;Exhibits;experimental study;flexibility;functional plasticity;gene-editing approach;Genetic;Genetic Techniques;Goals;hippocampal pyramidal neuron;Hippocampus;Hormonal;Hormonal Change;Hormone Receptor;Hormones;Image;improved;in vivo;insight;knock-down;Laboratories;Lateral;Location;Maps;Measures;Memory;Mentors;Microscope;miniaturize;Molecular;Morphology;Motility;multiphoton imaging;Mus;Nature;Nervous System Disorder;neural;neural circuit;neuromechanism;Neuromodulator;Neurons;neuroregulation;Neurosciences;novel;Odors;olfactory bulb;Olfactory Pathways;Ovarian hormone;Perception;Perimenopause;Periodicity;Phase;place fields;Play;Postdoctoral Fellow;prevent;Progesterone;Property;receptor;Research;Research Personnel;Research Project Grants;response;Rewards;Risk Factors;Role;Schizophrenia;Sensory;sex;Shapes;Site;skills;steroid hormone;Structure;Synapses;System;Techniques;Training;Training Programs;Transgenic Mice;two photon microscopy;two-photon;unsupervised learning;Vertebral column;Viral Genes;way finding;Wild Type Mouse;women versus men;Women's Health;Work

PROJECT_TITLE: Cyclic endocrine neuromodulation shapes sensory and spatial representations

STUDY_SECTION: NST

STUDY_SECTION_NAME: Neurological Sciences Training 3 Study Section[NST-3]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Mental Health;Opioid Misuse and Addiction;Opioids;Precision Medicine;Substance Misuse

ORG_CITY: MAYWOOD

ORG_NAME: LOYOLA UNIVERSITY CHICAGO

PHR: Project Narrative Our study addresses the critical intersection of Opioid Use Disorder (OUD) and Alcohol Use Disorder (AUD) in clinical settings, a significant public health challenge. Leveraging the Oracle Cerner EHR Real-World Data (CRWD) of over 100 million patients, we aim to analyze treatment patterns, outcomes, and predictive factors for patients with co-occurring OUD and AUD. This innovative research, exploring the potential of glucagon-like peptide-1 receptor agonists (GLP-1 RA) alongside traditional pharmacotherapies, seeks to significantly advance addiction medicine and inform effective, personalized treatment strategies.

PI_NAMEs: QEADAN, FARES  (contact)

PROGRAM_OFFICER_NAME: SENEVIRATNE, CHAMINDI

PROJECT_TERMS: Abstinence;acamprosate;addiction;Addictive Behavior;Address;Adherence;Affect;Agonist;alcohol use disorder;Alcoholic Intoxication;Anxiety;Appointment;Behavior;Buprenorphine;Characteristics;Clinical;clinical practice;comorbidity;Counseling;Data;Databases;Development;Diagnosis;Disease;Disulfiram;dosage;Drug Metabolic Detoxication;drug testing;dual diagnosis;effective therapy;Effectiveness;effectiveness evaluation;Emergency Situation;Event;Exhibits;FDA approved;GLP-I receptor;Guidelines;Health Policy;Hospitalization;hospitalization rates;improved;Individual;innovation;insight;liver function;Liver Function Tests;long term recovery;longitudinal analysis;Measures;Medicine;Mental Depression;Mental Health;Metabolic Diseases;Methadone;Minority Status;Naltrexone;novel;novel strategies;opioid overdose;Opioid replacement therapy;opioid use;opioid use disorder;Outcome;Patients;personalized medicine;Pharmaceutical Preparations;Pharmacotherapy;physical conditioning;Policies;poor health outcome;Predictive Factor;primary outcome;Procedures;Process;Prognosis;Public Health;Race;reduced substance use;Relapse;Research;Services;Severities;Structure;substance use;Symptoms;Therapeutic Agents;Translating;treatment adherence;Treatment outcome;treatment pattern;Treatment Protocols;treatment strategy;Update;Use Effectiveness;Variant;Visit

PROJECT_TITLE: Advancing Integrated Treatment for Co-Occurring Opioid and Alcohol Use Disorders: A Comprehensive Analysis of GLP-1 Receptor Agonists and Traditional Pharmacotherapies in Real-World Settings


ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

PHR: PROJECT NARRATIVE Chronic psychiatric disorders are the leading cause of disabilities worldwide, imposing substantial economic and societal burdens. Despite rises in psychiatric medications, >30% patients are treatment resistant, underscoring an urgency for innovative therapeutics. In this grant, we will systematically examine the acute and chronic effects of different psychedelics on murine neurophysiology.

PI_NAMEs: PADAWER-CURRY, JONAH  (contact)

PROJECT_TERMS: Acceleration;Acute;Address;Adolescent;Adult;Affect;antagonist;Antipsychotic Agents;Area;awake;Blood;Bolus Infusion;Brain;BRAIN initiative;Calcium;career;Chronic;Clinical Trials;cost;critical period;design;disability;Dissociation;Doctor of Philosophy;Dose;Drug Prescriptions;Economics;Exhibits;experimental study;Functional Magnetic Resonance Imaging;Future;Goals;Grant;Hallucinogens;hemodynamics;Hour;Human;imaging study;Immediate-Early Genes;indexing;Infusion procedures;Injections;innovation;interest;International;Intoxication;Length;Link;Maps;Measures;Mental disorders;Mentors;Modality;Molecular;monocular deprivation;Moods;Mus;N,N-Dimethyltryptamine;neural;Neuronal Plasticity;Neurons;neurophysiology;neurovascular coupling;novel;optical imaging;Outcome;Oxygen;Patients;Peer Review;Pharmaceutical Preparations;Phase;Postdoctoral Fellow;Process;Property;Psilocybin;Psychiatric therapeutic procedure;receptor;Reporting;Research;Research Personnel;Resistance;Rest;reward circuitry;Rewards;Risperidone;Serotonin;serotonin receptor;Serotonin Receptor 5-HT2A;Signal Transduction;social;Structure;Substance Use Disorder;symposium;symptomatic improvement;Synaptic plasticity;System;Testing;Therapeutic;Time;Training;treatment strategy;United States National Institutes of Health;Universities;vasoconstriction;Visual;Visual System;Washington;Work

PROJECT_TITLE: Effects of Psychedelics on Brain Function and Neuroplasticity


ORG_CITY: Chicago

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: PROJECT NARRATIVE The enclosed project aims to develop new therapeutic approaches for the fatal disorder, Niemann-Pick Type C. We will investigate the role of endogenous peptides as modulators of a newly identified receptor that can regulate cholesterol level as a means to develop treatments for this devastating disease.

PI_NAMEs: AAKALU, VINAY ;COLOGNA, STEPHANIE M (contact)

PROGRAM_OFFICER_NAME: MORRIS, JILL A

PROJECT_TERMS: Address;autosome;Biochemical;Biochemistry;Biological Markers;Central Nervous System;Cholesterol;clinical phenotype;Disease;emerging adult;extend lifespan;FDA approved;Functional disorder;Lipids;Mass Spectrum Analysis;Molecular Biology Techniques;Neimann-Pick's Disease Type C;Niemann-Pick Diseases;novel therapeutic intervention;Nuclear Pore Complex;Patients;Peptides;Peripheral;Phenotype;Proteins;receptor;Role

PROJECT_TITLE: Novel Therapeutic Approaches for NPC Disease

STUDY_SECTION: DDNS

STUDY_SECTION_NAME: Drug Discovery for the Nervous System Study Section[DDNS]


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Eye Disease and Disorders of Vision;Genetics;Neurosciences;Rare Diseases

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative Elucidating the dynamic relationship between increased experience-dependent neuronal activity and astrocyte transcriptional responses and their subsequent regulation of synaptic plasticity will offer a greater understanding of brain homeostasis. The proposed project investigates astrocyte transcriptional regulation in response to increased neuronal activity and how altering it may lead to increased plasticity in the adult brain. This offers the potential of gaining further understanding of the regulatory molecular and cellular mechanisms of cell-cell interactions in a healthy brain, and how when altered, these may contribute to diseases where alterations in synapse stability have been observed, such as glioma and schizophrenia.

PI_NAMEs: CONTRERAS, MINERVA  (contact)

PROJECT_TERMS: Adolescent;Adult;Age;age related;Astrocytes;Bioinformatics;Brain;cancer cell;career;Cell Communication;cell type;Cells;Central Nervous System Diseases;Code;critical period;Data;Dendrites;design;Development;Disease;disease model;Doctor of Philosophy;Environment;Excision;experience;experimental study;FOS gene;FOS Protein;Gene Expression;Genes;Genetic Transcription;Glioblastoma;Glioma;Goals;Health;Homeostasis;Immediate-Early Genes;Immunohistochemistry;in vivo imaging;in vivo two-photon imaging;Induced Neurons;Light;Malignant neoplasm of brain;Mediating;Mentors;Messenger RNA;Molecular;Molecular Biology;mRNA Expression;Mus;Nervous System Disorder;neural circuit;Neuroglia;Neuronal Plasticity;Neurons;Operative Surgical Procedures;Phase;Photic Stimulation;Play;Postdoctoral Fellow;Principal Investigator;Prognosis;Proliferating;Proteins;Regulation;Regulator Genes;Research;response;Role;Schizophrenia;Shapes;Signal Induction;single nucleus RNA-sequencing;skills;Synapses;Synaptic plasticity;synaptogenesis;targeted treatment;Techniques;Time;Training;transcription factor;Transcriptional Regulation;transcriptome;transcriptomics;tumor;tumor progression;Tumor Promotion;Vision;Visual;Visual Cortex;Visual Pathways;visual stimulus;Work

PROJECT_TITLE: Astrocyte experience-dependent regulation of synapse stability in the adult mouse visual cortex

STUDY_SECTION_NAME: Special Emphasis Panel[ZNS1 SRB-L (02)]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Maternal Health;Microbiome;Nutrition;Pediatric;Women's Health Research

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: PROJECT NARRATIVE Childhood undernutrition is a pervasive problem worldwide, resulting in reduced linear growth (stunting), increased risk of disease and cognitive defects that persist into adulthood. Maternal health profoundly influences fetal and childhood development, and mothers that are stunted are more likely to give birth to stunted children. Because gut microbes influence growth and immune function, we propose to investigate the role of the maternal microbiota in shaping offspring health, with the goal of identifying specific microbial species and immune pathways for targeted intervention to ameliorate the global burden of undernutrition.

PI_NAMEs: COWARDIN, CARRIE ADELINE (contact)

PROGRAM_OFFICER_NAME: RUSSO, DENISE

PROJECT_TERMS: Adult;Age;Birth;bone;Breeding;Cells;Cessation of life;Child;Child Health;Childbirth;Childhood;Cognitive;Cognitive deficits;cognitive function;Communicable Diseases;Complication;Data;Development;disorder risk;Education;Environment;experience;experimental study;fetal;Goals;Growth;gut microbes;gut microbiome;gut microbiota;Health;Immune;immune function;Immunity;Immunotherapeutic agent;improved;Infrastructure;insight;intergenerational;Intervention;Life;Malnutrition;Maternal Health;maternal immune system;maternal microbiome;maternal microbiota;member;Metabolic;Metabolic Diseases;Microbe;microbial;microbial community;microbiome;microbiota;Modeling;Mothers;mouse model;Mus;Neonatal;novel strategies;offspring;Pathway interactions;Phenotype;Play;Probiotics;Research;Risk;Role;Shapes;Signal Pathway;Syndrome;targeted treatment;Therapeutic Intervention;transmission process;Universities;Virginia;Vulnerable Populations;Weight

PROJECT_TITLE: The maternal microbiome in childhood growth and immunity during undernutrition


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Cervical Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Dissemination and Implementation Research;HIV/AIDS;Health Services;Infectious Diseases;Prevention;Primary Health Care;Sexually Transmitted Infections;Women's Health Research

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE This implementation science study examines integration of human papillomavirus (HPV) testing using self- sampling with routine HIV care in antiretroviral therapy (ART) clinics of Ethiopian public hospitals, describes opportunities for improved implementation of the integrated cervical cancer screening service, intervenes to enhance the screening, triage, and treatment cascade for women living with HIV (WLHIV) by engaging key implementers and stakeholders in a virtual peer learning community using Project ECHO, and evaluates effects of doing so. After building knowledge, awareness, and expertise of health professionals in five hospitals, technical support will be provided to select hospitals to catalyze implementation momentum. Approximately 30% of WLHIV test positive for HPV in Ethiopia; this study measures how successfully hospitals are able to move screen-positive individuals to triage and treatment and generates implementation information to inform scale-up of an integrated, patient-centered, point-of-care cancer screening model for WLHIV.

PI_NAMEs: HAILEMARIAM, DAMEN ;LOTT, BREANNE  (contact);MADHIVANAN, PURNIMA

PROJECT_TERMS: Acetic Acids;Address;Adherence;Advanced Malignant Neoplasm;Affect;Africa South of the Sahara;AIDS prevention;Algorithms;antiretroviral therapy;Awareness;Bilateral;Cancer Burden;Cancer Control;cancer prevention;Caring;Case Study;cell growth;Cervical;Cervical Cancer Screening;Cessation of life;Clinic;Clinics and Hospitals;Communities;Community Health;comorbidity;contextual factors;cost;Cost Analysis;cost comparison;Cost Effectiveness Analysis;cost-effectiveness evaluation;Costs and Benefits;Data;Decision Making;design;DNA;Early Diagnosis;effectiveness evaluation;Effectiveness of Interventions;effectiveness outcome;Ethiopia;Ethiopian;Evaluation;evidence base;experience;follow-up;Funding Opportunities;General Population;Goals;Guidelines;Health;Health care facility;Health Personnel;Health Professional;Health system;HIV;Hospitals;HPV positive;HPV screening;HPV-High Risk;Human immunodeficiency virus test;Human papilloma virus infection;Human Papillomavirus;implementation barriers;implementation cost;implementation efforts;implementation outcomes;implementation science;implementation strategy;implementation study;improved;Incidence;Individual;informant;Infrastructure;insight;International;Intervention;Interview;Knowledge;learning community;Lesion;Link;low and middle-income countries;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Measures;Methodology;Methods;microcosting;Modeling;Monitor;mortality;Needles;Notification;Outcome;Participant;patient oriented;Patients;peer learning;Persons;point of care;Policies;Population;premalignant;Prevalence;prevent;Preventable cancer cause;Prevention;Professional Practice;Provider;Public Health;Public Hospitals;Readiness;Reporting;Research Personnel;Resource-limited setting;Sampling;satisfaction;scale up;screening;Screening for cancer;screening guidelines;screening program;screening services;Services;Site;success;Surveys;Target Populations;Test Result;Testing;theories;Time;Tissues;tool;Training;Triage;Update;uptake;virtual;Visit;Visual;Woman;women's diagnosis;women's outcomes;World Health Organization

PROJECT_TITLE: Leveraging Project ECHO for improved cervical cancer screening in Ethiopia: An implementation study of integrated HPV selfsampling in HIV care centers


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Congenital Structural Anomalies;Genetics;Human Genome;Mental Health;Mental Illness;Neurosciences;Pediatric;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: BALTIMORE

ORG_DEPT: NEUROSCIENCES

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative: F99 Phase Cortical development is a complex and spatiotemporally sensitive process, that when gone awry, has been linked to a wide array of neuropsychiatric and neurodevelopmental disorders. Strict regulation of when, where, and how the cell division of neural progenitors occurs is crucial for typical cortical development. This research uses molecular biology techniques, spatial transcriptomics, and single cell sequencing on temporally labeled cells from mutant mouse models to better characterize how progenitor signaling, division time, and localization affect fate determination and cortical structure.

PI_NAMEs: NICHOLAS, ZACHARY BRYANT (contact)

PROJECT_TERMS: Affect;Alleles;Apical;autism spectrum disorder;Bar Codes;base;Binding;Bipolar Disorder;Brain;Cell Cycle;Cell Cycle Regulation;Cell division;cell type;Cells;Centrosome;Cerebral cortex;Cilia;cilium biogenesis;Complex;computerized tools;Coupling;Cues;Databases;Defect;Destinations;Development;diverse data;Ensure;Environment;Gene Expression;gene function;Genes;genetic epidemiology;genetic manipulation;genetic variant;genome wide association study;Genomics;gray matter;Individual;Induction of Apoptosis;Inherited;insight;Investigation;Knock-out;Knockout Mice;Knowledge;Label;Length;Link;Location;Macrocephaly;Measures;Mental disorders;Methodology;Methods;Microcephaly;Microgyria;Microtubules;Mitosis;Mitotic;Modeling;Molecular;Molecular Biology Techniques;Morphology;mouse model;mutant;mutant mouse model;Mutation;Neocortex;neocortical;nerve stem cell;neurodevelopment;Neurodevelopmental Disorder;Neuronal Differentiation;Neurons;neuropsychiatric disorder;Neurosciences;novel;Pathway interactions;Phase;Population;Population Genetics;Postdoctoral Fellow;Principal Investigator;Process;Production;progenitor;Proliferating;Regulation;Research;response;Role;Schizophrenia;Signal Transduction;single cell sequencing;single-cell RNA sequencing;skills;spatiotemporal;Specific qualifier value;Speed;stem cell division;stem cell fate;stem cell function;Structure;Surface;Techniques;Testing;Time;TP53 gene;Training;Transcript;transcriptome;transcriptomics;Variant;Ventricular;Visualization;Work

PROJECT_TITLE: Neural Progenitor Environmental Sense, Mitotic Time, and Mitotic Location and their Effects on Corticogenesis


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Clinical Research;Drug Abuse (NIDA only);Mental Health;Neurosciences;Opioids;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Substance Misuse

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

PHR: PROJECT NARRATIVE Children exposed to opioids antenatally can have behavioral problems, lower school achievement, and changes seen on brain MRI scans compared to unexposed children. In this multicenter study, Cincinnati is one of four centers enrolling a total of 200 exposed infants and 100 unexposed controls. We will follow this cohort to age 2 to evaluate brain structure and function, examine development and behavior, and determine the relative effects of opioid exposure versus other environmental factors on outcomes.

PI_NAMEs: MERHAR, STEPHANIE L (contact)

PROGRAM_OFFICER_NAME: CHAKHTOURA, NAHIDA ABDO

PROJECT_TERMS: 2 year old;Achievement;Age;antenatal;anxiety symptoms;Area;Behavior;Behavioral;Birth;Brain;brain magnetic resonance imaging;brain volume;Cerebrum;Certification;Child;Child Rearing;Childhood;clinical center;Clinical Research;clinical research site;cohort;Collaborations;connectome;Data;Data Coordinating Center;depressive symptoms;Development;Diffusion Magnetic Resonance Imaging;Enrollment;Environment;Environmental Risk Factor;experience;Exposure to;fetal opioid exposure;follow-up;Funding;Goals;Grant;gray matter;Healthcare;high risk infant;Home environment;Impairment;improved;Infant;Infrastructure;International;Life;Longitudinal Studies;Magnetic Resonance Imaging;Manuscripts;marijuana use;Measures;Medical;Mental Health;Methodology;Mothers;MRI Scans;Multicenter Neonatal Research Network;Multicenter Studies;National Institute of Child Health and Human Development;Neonatal;neurodevelopment;neuroimaging;Newborn Infant;nicotine use;Opioid;opioid exposure;opioid use;Outcome;participant retention;Patient Self-Report;Population;postnatal;Pregnancy;Problem behavior;Process;Productivity;Psychotropic Drugs;Publications;Publishing;Questionnaires;Research;Research Design;response;Rest;Sample Size;Schools;Site;social stigma;Standardization;Structure;success;Surface;Tissues;Training;Umbilical cord structure;Visit;white matter injury

PROJECT_TITLE: Outcomes of Babies with Opioid Exposure -- Cincinnati site renewal

STUDY_SECTION_NAME: Special Emphasis Panel[ZHD1 DSR-N (55)]


ED_INST_TYPE: SCHOOLS OF PHARMACY

ORG_CITY: PITTSBURGH

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PI_NAMEs: ZHANG, WEI  (contact)

PROGRAM_OFFICER_NAME: CHAO, CHIEN-CHUNG

PROJECT_TERMS: Absence of pain sensation;Acute Pain;addiction;Adhesions;Adhesives;Anesthesia procedures;Award;Benzodiazepines;Binding;Biocompatible Materials;Biodistribution;biomaterial compatibility;cancer therapy;career;career development;Cessation of life;chemical binding;chemical bond;chemical conjugate;Chemicals;Chemistry;chronic pain;Cicatrix;Constipation;crosslink;Crosslinker;design;Development;Devices;Drug Delivery Systems;Drug Kinetics;Drug Prescriptions;Economic Burden;efficacy study;empowerment;Encapsulated;Excision;experience;Formulation;functional group;Glues;Goals;Hematoxylin and Eosin Staining Method;improved;In Vitro;in vivo;in vivo imaging;Inflammation;innovation;interest;irradiation;Lasers;Light;light emission;Local anesthesia;Local Anesthetics;mechanical properties;Medical;Medicine;Mentors;Methods;Modeling;Nausea;Nerve;Nerve Block;novel;Operative Surgical Procedures;Opioid;Opioid Analgesics;overdose death;Pain;Pain management;pain relief;Particulate;Patients;Pattern;Pharmaceutical Preparations;Phase;physical property;Polymers;Positioning Attribute;prevent;Property;Pruritus;Quality of life;Rattus;Reaction;response;safety study;sciatic nerve;Science;Series;side effect;skills;Social Problems;Source;Stains;System;Testing;Tetrazolium;Time;Tissue Adhesives;Tissues;Training;Work;wound healing

PROJECT_TITLE: Light triggered materials for on-demand local anesthesia and tissue adhesive dissolution

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Genetics;Hematology;Neurosciences

ORG_CITY: NOTRE DAME

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF NOTRE DAME

ORG_STATE: IN

PHR: PROJECT NARRATIVE Constructing the brain requires the coordination of several different cell types that permanently reside within the central nervous system. One of these cell types, microglia, is the resident immune cell of the CNS and must be produced during embryogenesis to maintain brain homeostasis throughout life. We are studying gene regulatory networks governing microglia production during embryogenesis to help identify novel genes that can expand the knowledge of genetic risk factors and therapeutic targets for diseases where microglia are the cause.

PI_NAMEs: HOOVER, CAMDEN  (contact)

PROJECT_TERMS: Adult;Age;Alzheimer's Disease;autism spectrum disorder;Blood;Blood Vessels;Bone Marrow;Brain;brain cell;brain parenchyma;Cell Physiology;cell type;Cells;Central Nervous System;Cephalic;Clinic;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;cranium;CRISPR screen;Data;Development;developmental disease;Diagnosis;Diagnostic tests;Disease;Embryo;Embryonic Development;Endoderm;Endothelium;Functional disorder;gene regulatory network;Gene Transfer Techniques;Genes;Genetic;genetic manipulation;genetic risk factor;Genetic Screening;Genetic study;Genetic Transcription;genetic variant;Goals;Hematopoietic;Heterogeneity;Homeostasis;Human;human disease;Image;Immune;Immune system;Immunity;Immunofluorescence Immunologic;In Situ Hybridization;in vivo;in vivo imaging;Infiltration;Injury;intravital imaging;Investigation;Knowledge;Label;Learning;Life;Link;Lymphatic;lymphatic vessel;mannose receptor;Maps;Membrane;Meninges;Messenger RNA;Microglia;model organism;monocyte;Multiple Sclerosis;Mus;Mutagenesis;mutant;Mutation;Myelogenous;myeloid cell development;Myeloid Cells;Nervous System Disorder;Nervous System Physiology;network architecture;Neurodegenerative Disorders;Neurodevelopmental Disorder;neuronal circuitry;Neurons;neutrophil;novel;Pathway interactions;Phase;Play;Population;postnatal;postnatal development;Process;Production;programs;pup;receptor;Regulation;Regulatory Element;Research;response to injury;Role;Site;skills;Source;source localization;SOX17 gene;Stains;Testing;theories;Therapeutic;therapeutic target;timeline;transcription factor;transdifferentiation;Variant;Venous;Visualization;Work;Zebrafish

PROJECT_TITLE: Investigating novel gene regulatory networks for development of myeloid cells


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Diabetes;Mental Health;Neurosciences;Nutrition;Prevention;Social Determinants of Health

ORG_CITY: Newark

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: PROJECT NARRATIVE Social isolation is an independent risk factor for diabetes and dementia. However, the neural mechanism underlying the relationship between social connection, glucose homeostasis, and dementia is poorly understood. This combined F99/K00 research strategy bears public health significance and will contribute neurobiological insight underlying the relationship between loneliness, glucose regulation and cognitive function.

PI_NAMEs: LAMONT, HANNAH  (contact)

PROJECT_TERMS: Address;Affect;Age-associated memory impairment;Aging;Alzheimer's Disease;Area;behavior test;Biochemical;Biological Assay;blood glucose regulation;Brain;Calcium;career development;Cells;Clinical;Cognitive;Cognitive aging;cognitive function;cognitive testing;comparison control;CRISPR/Cas technology;Data;Databases;Dementia;dementia risk;Development Plans;Diabetes Mellitus;Electrophysiology (science);energy balance;Epidemic;experimental study;extracellular;Fellowship;Female;Fiber;Foundations;frailty;Glucose;glycemic control;Health;Health and Retirement Study;high risk population;Homeostasis;House mice;human model;Hyperglycemia;Hyperglycemic Mice;Hypoglycemia;Hypothalamic structure;In Vitro;in vivo;insight;knock-down;Link;Literature;Loneliness;male;Mediating;Memory;Metabolic;Metabolic Diseases;Methods;Mus;Neurobiology;Neurohormones;neuromechanism;Neurons;Neurosciences;Nitric Oxide Synthase Type I;older adult;optogenetics;Oxytocin;Oxytocin Receptor;patch clamp;patient subsets;Pattern;Performance;Peripheral;Phase;Phenotype;Photometry;Population;pre-clinical;prevent;Property;Public Health;receptor;Receptor Cell;receptor expression;Reporting;Research;response;Risk Factors;Rodent Model;Role;secondary analysis;Sex Differences;skills;Slice;social;Social Behavior;Social Environment;Social Interaction;Social isolation;social relationships;Surgeon;Training;Transportation;United States

PROJECT_TITLE: Social Isolation and Metabolic Homeostasis: Investigating the Role of Oxytocin in Modulating Hypothalamic Glucose Sensing


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Drug Abuse (NIDA only);Mental Health;Neurosciences;Opioid Misuse and Addiction;Opioids;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Substance Misuse

ORG_CITY: RESEARCH TRIANGLE PARK

ORG_NAME: RESEARCH TRIANGLE INSTITUTE

ORG_STATE: NC

PHR: PROJECT NARRATIVE Limited data are available on the effects of in utero opioid exposure beyond the newborn period. The Outcomes of Babies with Opioid Exposure (OBOE) Study will examine longitudinal advanced MRI imaging and developmental and behavioral outcomes of infants exposed to opioids in utero and unexposed infants from birth to 2 years of age. As the Data Coordinating Center, RTI International will maximize the productivity of the OBOE Study by ensuring rigorous and consistent standards for study design, implementation, data collection, quality assurance, monitoring, and statistical analysis and by providing logistical support for day-to-day functioning and for meetings and conference calls, fostering effective communication, facilitating collaboration, coordinating external services, developing and maintaining a Consortium website, and managing Clinical Center capitation through the implementation of an efficient and accurate payment system.

PI_NAMEs: BANN, CARLA M (contact);NEWMAN, JAMIE ELIZABETH

PROJECT_TERMS: 2 year old;Adult;Age;antenatal;behavioral outcome;Birth;Brain;Budgets;Child;Child Development;Child Rearing;clinical center;Clinical Management;clinical practice;Clinical Trials;Collaborations;Communication;Data;data acquisition;Data Analyses;Data Collection;Data Coordinating Center;data management;Data Management Resources;Data Science;design;Development;Dose;Eating;economic impact;Ensure;experience;Exposure to;Fetus;flexibility;follow-up;Follow-Up Studies;Fostering;Funding;Future;Generations;Grant;Guidelines;Health;Helping to End Addiction Long-term;Home environment;Human Resources;Image;in utero;Infant;infant outcome;Informed Consent;Infrastructure;innovation;International;Lead;Leadership;Life;Longitudinal cohort study;Longitudinal Studies;Magnetic Resonance Imaging;maternal opioid use;Medical;Medical center;medical examination;meetings;Mental Health;Monitor;Multicenter Neonatal Research Network;National Institute of Child Health and Human Development;Neonatal;Neonatal Abstinence Syndrome;neonate;neurodevelopment;neuroimaging;Newborn Infant;Observational Study;Opiate Addiction;Opioid;opioid epidemic;opioid exposure;Outcome;participant enrollment;payment;Perinatal;Pharmacological Treatment;prenatal exposure;Process;Productivity;prospective;Protocols documentation;Publications;Publishing;Qualifying;quality assurance;Recording of previous events;Regulation;Reporting;Research;Research Design;Research Personnel;Research Support;Resources;response;Role;Running;Serial Magnetic Resonance Imaging;Services;Site;Sleep;social health determinants;Social Impacts;Specific qualifier value;Standardization;Statistical Data Interpretation;Structure;success;symposium;Symptoms;System;tool;Training;United States;United States National Institutes of Health;Weaning;web site

PROJECT_TITLE: HEAL Initiative: Antenatal Opioid Exposure Longitudinal Study Consortium


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

ORG_CITY: ROOTSTOWN

ORG_NAME: NORTHEAST OHIO MEDICAL UNIVERSITY

PHR: Narrative The 10th installment of the Midwest Auditory Research Conference (MARC) will be hosted by the Hearing Research Group at Northeast Ohio Medical University (NEOMED), and take place in the NEOMED Education and Wellness Conference Center in Rootstown OH on June 19-21, 2025. Since 2005, the MARC has provided a collegial, accessible, and affordable venue for principal investigators and trainees, fostering collaboration to advance the goals of better understanding auditory and vestibular function and improving related health outcomes. The 10th MARC includes several initiatives to improve diversity and inclusivity at the conference, and to promote sustained diversity in auditory and vestibular research.

PI_NAMEs: ROSEN, MERRI J. (contact)

PROGRAM_OFFICER_NAME: CYR, JANET

PROJECT_TERMS: Academia;Achievement;American Sign Language;Animals;Anniversary;Area;Auditory;Auditory system;Automobile Driving;Award;Behavioral Research;Biomedical Research;career;Career Choice;Caring;Clinical Research;Cochlea;Coffee;Collaborations;Communication;Communities;cost;cost effective;Development;digital;Directories;Disease;diversity and inclusion;Education;Ensure;Equilibrium;Event;experience;Family;Feedback;Fostering;Friends;Goals;graduate student;Health;Hearing;Home;Human;improved;Industry;insight;Institution;Lactation;lectures;Medical;meetings;Michigan;Midwestern United States;Mission;Molecular Biology;Museums;National Institute on Deafness and Other Communication Disorders;next generation;Ohio;Otolaryngology;Outcome;Participant;peer;Postdoctoral Fellow;posters;Principal Investigator;Process;Productivity;Psychoacoustics;Relaxation;Research;Research Institute;Research Personnel;Research Training;satisfaction;Science;Scientific Advances and Accomplishments;Scientist;Seasons;Series;Services;Strategic Planning;success;Suggestion;Surveys;symposium;Techniques;Time;Training;translational potential;Translational Research;Translations;Travel;Underrepresented Populations;Universities;University Hospitals;Vestibular function;vestibular system

PROJECT_TITLE: The 10th Midwest Auditory Research Conference (MARC)

STUDY_SECTION_NAME: Special Emphasis Panel[ZDC1 SRB-K (13)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Down Syndrome;Intellectual and Developmental Disabilities (IDD);Neurodegenerative;Pediatric

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE. People with Down syndrome display increased risk of developing diverse co-occurring conditions, but the mechanisms driving this unique clinical profile are yet to be defined. This project will develop a biobanking research infrastructure that could support a wide range of investigations by a multidisciplinary team of researchers through the collection of diverse biospecimens using harmonized protocols. These activities will greatly accelerate the pace of discoveries benefiting persons with Down syndrome.

PI_NAMEs: ESPINOSA, JOAQUIN M. (contact);GALBRAITH, MATTHEW D;HEAD, ELIZABETH ;RACHUBINSKI, ANGELA LYNN

PROGRAM_OFFICER_NAME: RYAN, LAURIE M

PROJECT_TERMS: Acceleration;Alzheimer's Disease;Alzheimer’s disease biomarker;Amniotic Fluid;autism spectrum disorder;Autoimmune Diseases;Automobile Driving;Autopsy;biobank;Biopsy;Blood;brain tissue;Catalogs;Chorionic villi;Clinical;clinical risk;cohort;Cohort Studies;Collaborations;Collection;Communities;Congenital Heart Defects;Consultations;Cultural Backgrounds;Data Coordinating Center;data hub;data modeling;Data Set;Development;Diet Habits;Down's Syndrome;Epigenetic Process;Epilepsy;Ethnic Origin;Etiology;Evolution;experience;extend lifespan;Feces;Feedback;Functional disorder;Funding;Future Generations;Genetic Diseases;genetic makeup;Goals;Growth;Health;Heterogeneity;Human;Hypertension;Immune;improved;Individual;Infrastructure;Ingestion;inter-individual variation;Investigation;leukemia;Leukocytes;life span;Life Style;Malignant Neoplasms;Medical;member;metabolome;Metadata;microbiome;multidisciplinary;multiple omics;novel;Oral;Outcome;Participant;Persons;Phenotype;Plasma;Population;Principal Investigator;Procedures;Process;Program Development;Proteome;Protocols documentation;Race;Recommendation;Research;Research Infrastructure;Research Personnel;Resources;Respiratory Tract Infections;Risk;Saliva;Sampling;Services;Severities;sex;Site;Skin;Socioeconomic Status;Solid;Standardization;Swab;Tissues;Tongue;Tonsil;Training Activity;trait;transcriptome;Umbilical Cord Blood;United States National Institutes of Health;Urine;Variant;virtual;web based interface;working group

PROJECT_TITLE: The INCLUDE Project Down Syndrome Biorepository (DS-Biorepository)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IVBH-N (55)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Sleep Research

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE To understand the neurobiological basis of memory disorders, we need to first grasp how memories are encoded and consolidated under normal, healthy conditions. This proposal aims to combine new high-resolution optical, electrophysiological, and molecular approaches to characterize the cellular and subcellular mechanisms of memory formation and storage under physiological conditions. These experiments will deepen our understanding of the functional role of hippocampal dendrites in memory encoding and consolidation and will also help to identify key mechanisms behind neuronal diseases such as Alzheimer's and other memory-related disorders.

PI_NAMEs: GONZALEZ, KEVIN C (contact)

PROJECT_TERMS: Action Potentials;Address;Alzheimer's Disease;Apical;Automobile Driving;awake;Award;Axon;Behavior;Behavioral;Brain;BRAIN initiative;Cell model;Cell Physiology;Cells;Communication;Computer Analysis;Dendrites;Dendritic Spines;Disease;Distal;Electrophysiology (science);Electroporation;Environment;Episodic memory;Event;Exhibits;experience;experimental study;extracellular;Glutamates;Goals;grasp;hippocampal pyramidal neuron;Hippocampus;Image;Imaging technology;in vivo;Individual;Knowledge;Laboratories;large scale data;Link;Location;long term memory;Mammals;Measures;Membrane Potentials;Memory;memory consolidation;Memory Disorders;memory encoding;Molecular;Monitor;Mus;neural;Neurobiology;neuronal cell body;Neurons;Neurophysiology - biologic function;Neurosciences;non rapid eye movement;Opsin;Optics;optogenetics;Organism;patch clamp;Pathologic;Pattern;Phase;Physiological;Physiological Processes;place fields;Population;Postdoctoral Fellow;Research;Research Personnel;Resolution;Role;segregation;sensor;Signal Transduction;skills;Sleep;Source;spatial memory;Structure;Synapses;Synaptic plasticity;Techniques;Testing;Time;tool;Training;transmission process;two-photon;Vertebral column;way finding;Weight;Work

PROJECT_TITLE: Subcellular plasticity mechanisms of hippocampal-dependent memory formation and consolidation


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Emergency Care;Epilepsy;Neurodegenerative;Neurosciences

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Same as parent award 5K23NS116128. Early treatment is vital for patients with status epilepticus to avoid preventable morbidity and mortality but there is evidence that the majority of patients fail to receive adequate prehospital care. Identifying the causes and clinical implications of this gap is critical for improving outcomes among patient with status epilepticus and has broader implications about the delivery of prehospital medical care overall.

PI_NAMEs: GUTERMAN, ELAN  (contact)

PROGRAM_OFFICER_NAME: REZAIZADEH, KAVON PAUL

PROJECT_TERMS: Address;Affect;Benzodiazepines;Biostatistical Methods;Caring;Clinical;Computerized Medical Record;Data;Dedications;Dose;Early treatment;Emergency medical service;Ensure;evidence base;examination questions;Failure;Future;Goals;Guidelines;Hospital Administration;Hospitals;implementation science;improved;improved outcome;insight;Instruction;Medical;Mentors;Morbidity - disease rate;mortality;Outcome;parent project;Patients;Persons;Pharmaceutical Preparations;Pre-hospitalization care;prospective;Protocols documentation;Provider;Qualitative Methods;Records;Research;Research Design;Research Methodology;Research Personnel;respiratory;Risk;Seizures;skills;Status Epilepticus;treatment and outcome;Treatment Protocols;Ventilatory Depression

PROJECT_TITLE: Prehospital Management of Status Epilepticus

STUDY_SECTION_NAME: NST-1 Study Section[NST-1]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Genetics;Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: SYRACUSE

ORG_NAME: UPSTATE MEDICAL UNIVERSITY

PHR: Project Narrative Behavioral variant frontotemporal dementia (bvFTD) is a leading cause of presenile dementia and is an incurable neurodegenerative disease where loss of empathy occurs; the underlying neural mechanisms underlying are essentially unknown. This study will explore oxytocin signaling enhancement as a novel therapeutic treatment for the loss of empathy and will elucidate how neuronal activity and associated molecular signatures within empathy circuits change across the lifespan during healthy aging and bvFTD, with the overall goal to provide novel therapeutic targets to improve quality of life. Successful completion of this fellowship application will generate important insights into bvFTD pathogenesis and therapy and provide valuable training necessary to launch my career as an academic scientist.

PI_NAMEs: KOBEISSI, AYA  (contact)

PROJECT_TERMS: Age Months;age related;age related decline;aged;Aging;aging process;aging related;Arginine;Atrophic;Behavior;Behavioral Assay;behavioral variant frontotemporal dementia;Brain;C9ORF72;calmodulin-dependent protein kinase II;career;cell type;Cells;Cessation of life;Dementia;Dipeptides;Disease;Disease Progression;Disinhibition;Distress;electrical property;Electrophysiology (science);Emotional;Empathy;Exhibits;experimental study;FDA approved;Fellowship;frontal lobe;Frontotemporal Dementia;Gene Expression Profile;Gene Transfer;Genetic;genetic manipulation;Goals;healthy aging;hippocampal pyramidal neuron;Hormones;Impairment;improved;in vivo;Individual;insight;Learning;life span;Mediating;middle age;Molecular;Molecular Profiling;mouse model;Mus;Mutant Strains Mice;Nervous System;neural circuit;Neurodegenerative Disorders;neuromechanism;Neuromodulator;neuronal excitability;Neurons;neurophysiology;Neurophysiology - biologic function;new therapeutic target;normal aging;novel therapeutic intervention;novel therapeutics;optogenetics;Oxytocin;Oxytocin Receptor;patch clamp;patch sequencing;Pathogenesis;Pathogenicity;Pathology;Pattern;Personality;Phase;Postdoctoral Fellow;Prefrontal Cortex;Presenile Dementia;Process;Prosencephalon;Proteins;Pyramidal Cells;Quality of life;Research;Research Personnel;restoration;Role;Scientist;Secure;Signal Transduction;single-cell RNA sequencing;Site;skills;Slice;social engagement;Symptoms;Temporal Lobe;tenure track;Testing;Therapeutic;therapeutic development;therapeutic target;Training;transcriptomics;Transgenic Mice;treatment strategy;Untranslated RNA;Viral

PROJECT_TITLE: Prefrontal Cortical Circuits in Aging and Frontotemporal Dementia


NIH_SPENDING_CATS: Cancer;HIV/AIDS;Hematology;Hodgkin's Disease;Infectious Diseases;Lymphatic Research;Lymphoma;Orphan Drug;Rare Diseases

ORG_CITY: CHAPEL HILL

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: NARRATIVE Epstein-Barr Virus (EBV) is the etiological agent of several malignancies including Hodgkin lymphoma (HL) and multiple types of non-Hodgkin lymphoma (NHL) such as post-transplant lymphoproliferative disease (PTLD), diffuse large B cell lymphomas (DLBCL), T cell lymphomas, NK/T cell lymphoma (NKTL), and Burkitt's lymphoma (BL). We propose to determine the mechanism by which EBV drives lymphomagenesis and identify new therapeutics for EBV-associated lymphomas.

PI_NAMEs: DAMANIA, BLOSSOM A (contact)

PROGRAM_OFFICER_NAME: READ-CONNOLE, ELIZABETH LEE

PROJECT_TERMS: activation-induced cytidine deaminase;Address;Animal Model;Apoptosis;B-Lymphocytes;Binding;Binding Proteins;Burkitt Lymphoma;Cell Physiology;Cell Proliferation;Cells;chemotherapy;Cytosine;Deamination;design;Development;DNA;ds-DNA;Enzymes;Epstein-Barr pathogenesis;Epstein-Barr Virus Infections;Epstein-Barr Virus-Related Lymphoma;Etiology;Gene Expression;Genes;Genomic DNA;Genomic Instability;Hematologic Neoplasms;Hematopoietic Neoplasms;Hodgkin Disease;Human;Human Herpesvirus 4;In Vitro;in vivo;infected B cell;inhibitor;knock-down;large cell Diffuse non-Hodgkin's lymphoma;Libraries;Lymphoma;Lymphoma cell;Lymphomagenesis;Lymphoproliferative Disorders;Maintenance;Malignant Neoplasms;Mediating;Morbidity - disease rate;mortality;mouse model;Mutation;new therapeutic target;Non-Hodgkin's Lymphoma;novel therapeutic intervention;novel therapeutics;overexpression;Play;Population;post-transplant;prevent;Proliferating;Protac;Proteins;Proteomics;Reporting;response;Role;small molecule inhibitor;T-Cell Lymphoma;Testing;tumor;tumor growth;Tumor Suppressor Proteins;Up-Regulation;Uracil;Viral Genes;Viral Proteins;Work

PROJECT_TITLE: Targeting EBV-associated lymphomas

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 RPRB-H (M2)]


NIH_SPENDING_CATS: Genetics

ORG_CITY: SAN ANTONIO

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

PHR: Project Narrative/Relevance Statement Our studies will make important contributions to help clarify the mechanisms of centromere maintenance and specify the role of EWSR1 in centromere function and chromosome segregation, which will lead to insights relevant to health and disease, including cancer, birth defects, and developmental disorders such as Down syndrome.

PI_NAMEs: KITAGAWA, KATSUMI  (contact)

PROGRAM_OFFICER_NAME: VATAKIS, DIMITRIOS NIKOLAOS

PROJECT_TERMS: Auxins;Binding;Biochemical;Cell Cycle;Cell Cycle Stage;Cell division;Cells;Centromere;centromere protein A;Chimeric Proteins;Chromatids;Chromatin;Chromosomal Instability;Chromosome Segregation;Chromosomes;Congenital Abnormality;Data;daughter cell;Defect;Deposition;Development;developmental disease;Disease;DNA;DNA biosynthesis;DNA Sequence;Down's Syndrome;Engineering;Ensure;Ewings sarcoma;EWSR1 gene;FLI1 gene;Functional disorder;G1 Phase;Goals;Health;Histone H3;Human;Hybrids;Impairment;insight;Interphase;Kinetochores;Maintenance;Malignant Neoplasms;Mammals;Microtubules;Mitosis;Modeling;Molecular Chaperones;mutant;Mutation;Nucleosomes;Oncogenic;Phase;Phenotype;Play;prion-like;protein complex;Proteins;RNA;RNA Binding;RNA Recognition Motif;Role;segregation;SETX gene;Signal Transduction;Sister Chromatid;Specific qualifier value;Specificity;Structure;System;TAF15 gene;Testing;transmission process;Variant

PROJECT_TITLE: THE ROLE OF EWSRI AT CENTROMERE-


NIH_SPENDING_CATS: Genetics;Infectious Diseases

ORG_CITY: CAMBRIDGE

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

PHR: PROJECT NARRATIVE Elongating RNA polymerase (RNAP) is a well-established nexus of gene regulation in bacteria, yet it is unknown why RNAP from the model gram-positive bacterium Bacillus subtilis travels much faster than RNAP from its gram-negative counterpart, Escherichia coli. The goal of my proposal is to determine why B. subtilis RNAP is faster than E. coli RNAP and how this impacts the function of B. subtilis RNAP-associated factors in co-transcriptional gene regulation. The results of these studies will establish mechanistic details of B. subtilis RNAP elongation, which will be relevant in understanding transcription in related pathogenic bacteria.

PI_NAMEs: BATTAGLIA, ROBERT A (contact)

PROGRAM_OFFICER_NAME: RIGAS, MARC

PROJECT_TERMS: Affect;Antibiotics;Area;Bacillus subtilis;Bacteria;Binding;Bioinformatics;Biological;Biology;Biophysics;career;Characteristics;Clostridium difficile;Coupling;Data Analyses;design;Development;DNA-Directed RNA Polymerase;environmental change;Enzymes;Escherichia coli;experience;Experimental Designs;experimental study;Fellowship;Firmicutes;Frequencies;Gene Expression;Gene Expression Regulation;Genes;Genetic;genetic approach;Genetic Screening;Genetic Transcription;Goals;Gram-Positive Bacteria;Growth;Guanosine Tetraphosphate;Holoenzymes;In Vitro;in vivo;Knock-out;Knowledge;lens;Life;Massachusetts;Measures;Mediating;Mentors;Messenger RNA;Microscopy;Modeling;Molecular;Mutagenesis;mutant;novel;Nucleotides;Organism;pathogen;pathogenic bacteria;Phenotype;Positioning Attribute;Postdoctoral Fellow;Process;rate of change;Regulation;Research;Research Infrastructure;Resolution;Role;Scientist;single molecule;Site;skills;Speed;Staphylococcus aureus;Technology;Testing;Training;Transcriptional Regulation;transcriptome sequencing;Translations;Travel;Work

PROJECT_TITLE: Determinants of elongation rate differences between B. subtilis and E. coli RNA polymerases


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences;Nutrition;Obesity

ORG_CITY: PULLMAN

ORG_NAME: WASHINGTON STATE UNIVERSITY

ORG_STATE: WA

PHR: PROJECT NARRATIVE Ingestion of a meal can elicit both positive (rewarding) and negative (aversion/nausea) feelings, and maladaptive changes in these feelings could have broad implications, not only for the overconsumption of food that can lead to obesity, but also for emotional disorders. It is therefore critical to understand the neuronal circuitry underlying the positive and negative valences associated with food intake. The goal of the F99 portion of this proposal is to investigate the cellular mechanisms underlying divergent activation of hindbrain neurons by positively and negatively associated signals, while the goal of the K00 portion is to learn manipulation and recording methods to interrogate neuronal pathways in-vivo.

PI_NAMEs: WINZENRIED, ERIC THOMAS (contact)

PROJECT_TERMS: Adult;Aversive Therapy;Behavior;Behavioral;Behavioral Model;Brain;Brain region;career;Cause of Death;Cells;Cholecystokinin;Communication;Computer Models;Diabetes Mellitus;Disparate;Eating;Eating Disorders;Electrophysiology (science);Emotional disorder;experimental study;Fatty acid glycerol esters;Feedback;feeding;Feeling;Fiber;food consumption;Future;Genetic;Glutamates;Goals;Health;Heart Diseases;hindbrain;Hyperphagia;Hypothalamic structure;in vivo;Ingestion;Injections;Investigation;Label;Learning;Learning Skill;Malignant Neoplasms;Mediating;Mentors;Metabolic Diseases;Methods;Modality;N-Methylaspartate;Nausea;Negative Valence;nerve supply;neural circuit;neuronal circuitry;Neurons;Nucleus solitarius;Obesity;obesity prevention;obesity treatment;optogenetics;parabrachial nucleus;Pathway interactions;Peptides;Pharmaceutical Preparations;Phase;Photometry;Physiological;Population;Positioning Attribute;Positive Valence;Postdoctoral Fellow;Potassium;Records;Reporting;Research;Research Personnel;Research Project Grants;Rewards;Satiation;Serotonin;Serotonin Receptors 5-HT-3;side effect;Signal Transduction;Site;Slice;Stomach;Stretching;Stroke;Synapses;Techniques;Testing;Therapeutic;therapy development;Training;United States;Vagus nerve structure;Work

PROJECT_TITLE: Synapse to behavior, interrogating pathways underlying the control of food intake


NIH_SPENDING_CATS: Behavioral and Social Science;Biomedical Imaging;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Drug Abuse (NIDA only);Mental Health;Neurosciences;Opioid Misuse and Addiction;Opioids;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Substance Misuse

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: PROJECT NARRATIVE Children exposed to opioids antenatally can have behavioral problems, lower school achievement, and changes seen on brain MRI scans compared to unexposed children. The CHOP/PENN site is one of 4 sites to enroll 200 exposed infants and 100 unexposed controls as part of the OBOE (Outcomes of Babies with Opioid Exposure) study. As part of this RFA, we will follow this cohort to age 2 to evaluate brain structure and function, examine development and behavior, and determine the relative effects of opioid exposure versus other environmental factors on outcomes.

PI_NAMEs: DEMAURO, SARA BONAMO (contact);LORCH, SCOTT A

PROJECT_TERMS: 2 year old;Achievement;Address;Age;American;antenatal;anxiety symptoms;Area;Behavior;Behavioral;Birth;Brain;brain magnetic resonance imaging;brain volume;Cerebrum;Certification;Child;Child Rearing;clinical center;Clinical Research;clinical research site;cohort;Collaborations;connectome;Data;Data Coordinating Center;depressive symptoms;Development;Diagnosis;Diffusion Magnetic Resonance Imaging;Enrollment;Environment;Environmental Risk Factor;experience;Exposure to;fetal opioid exposure;follow-up;Funding;Goals;Grant;gray matter;Health Expenditures;Healthcare;Helping to End Addiction Long-term;high risk infant;Home environment;Hospitals;Impairment;improved;Incidence;Infant;Infrastructure;International;Intervention;Life;Longitudinal Studies;Magnetic Resonance Imaging;Manuscripts;marijuana use;Measures;Medical;Mental Health;Methodology;Mothers;MRI Scans;Multicenter Neonatal Research Network;National Institute of Child Health and Human Development;Neonatal;Neonatal Abstinence Syndrome;neurodevelopment;neuroimaging;Newborn Infant;nicotine use;Opioid;opioid exposure;opioid use;Outcome;participant retention;Patient Self-Report;Patients;Population;postnatal;Pregnancy;Problem behavior;Process;Productivity;Psychotropic Drugs;Public Health;Publications;Publishing;Questionnaires;recruit;Reporting;Research Design;response;Rest;Sample Size;Schools;Site;social stigma;Standardization;Structure;success;Surface;Tissues;Training;Umbilical cord structure;white matter injury