ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Assistive Technology;Behavioral and Social Science;Bioengineering;Brain Disorders;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Dissemination and Implementation Research;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Palliative Care

ORG_CITY: Nashville

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: Project Narrative As an increasing number of older adults are suffering from Mild Cognitive Impairment (MCI), Alzheimer's disease (AD) and AD-related dementias (ADRD); providing them with quality care in long term care (LTC) facilities is becoming problematic due to resource limitations, nursing shortage and high turnover among LTC nursing personnel. A novel approach to utilize socially assistive robotic systems that can meaningfully engage this group of older adults through physical, cognitive and social activities is proposed in the hope that such smart technology will be able to augment, and not replace, the current system of care. This study will contribute to the development of improved intelligent technology as an effective approach to engage older persons with dementia with the long- term goal of enhancing their function and quality of life as well as improving LTC staff satisfaction.

PI_NAMEs: SARKAR, NILANJAN  (contact);TATE, JUDITH ANN

PROGRAM_OFFICER_NAME: KIM, THERESA YOUNGJOO

PROJECT_TERMS: adaptive robot;Address;age-related disease;algorithm development;Alzheimer's Disease;Alzheimer's disease related dementia;Animals;Applications Grants;Architecture;Assisted Living Facilities;assistive robot;care systems;Caregivers;Caring;Clinical;Clinical Trials;Cognitive;cognitive function;Crossover Design;Data;Dementia;design;Development;Discipline of Nursing;effective intervention;Elements;Family;Family member;Focus Groups;Formal caregiver;Fostering;Frustration;Future;future implementation;Goals;Grant;Health care facility;Human;Human Resources;humanoid robot;Impaired cognition;implementation evaluation;implementation trial;improved;Individual;informal caregiver;information gathering;innovation;Intervention;Interview;Libraries;Long-Term Care;Long-Term Care Nursing;Mediating;Mediation;Medicare/Medicaid;Methods;mild cognitive impairment;Mission;mortality;Multi-Institutional Clinical Trial;multimodality;Nature;new technology;novel;novel strategies;Nursing Homes;Nursing Staff;older adult;Older Population;Participant;Personal Satisfaction;Persons;pharmacologic;Phase;Physical Function;physical impairment;Prevalence;Procedures;Quality of Care;Quality of life;Randomized;Randomized, Controlled Trials;Research;Resources;Robot;robotic system;Robotics;satisfaction;Science;Site;smart technologies;social;social assistive robot;Social Functioning;Social intelligence;Social Interaction;Social isolation;software development;Stress;System;Technology;Testing;Time;treatment as usual;Trust;United States Centers for Medicare and Medicaid Services;user centered design;usual care arm;virtual;virtual environment;Work

PROJECT_TITLE: Impact of a Novel Socially Assistive Robotic Architecture on Engaging Older Adults with Mild Cognitive Impairment, Alzheimer's Disease, and Related Dementia in Long Term Care Settings

STUDY_SECTION: NRCS

STUDY_SECTION_NAME: Nursing and Related Clinical Sciences Study Section[NRCS]


ADMINISTERING_IC: HG

ARRA_FUNDED: N

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

ORG_CITY: BOSTON

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: DANA-FARBER CANCER INST

ORG_STATE: MA

PHR: Project Narrative De no!ID haplotype-resolved genome assembly is the most comprehensive solution to understand genomic sequences. This proposal aims to develop cost-effective computational methods for high-quality haplotype-resolved assemblies by utilizing multiple sequencing technologies. The new assembly algorijhms in this proposal not only could be used by large-scale sequencing consortiums such as the Human Pangenome Reference Consortium (HPRC) and the Genome in a Bottle (GIAB), but also could pave the way to personal genome assembly for genomic research and clinical applications.

PI_NAMEs: CHENG, HAOYU  (contact)

PROGRAM_OFFICER_NAME: WETTERSTRAND, KRIS A

PROJECT_TITLE: Robust and cost-effective computational methods for haplotype-resolved genome assemblies

STUDY_SECTION: GNOM

STUDY_SECTION_NAME: Genome Research Study Section[GNOM-G]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Pediatric;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: Chicago

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative The purpose of this grant is to study a model of mental health navigation for African American and Latinx children in high poverty urban communities focused on reducing key parental attitudinal barriers to care. The study will examine the effectiveness of two types of navigators: paraprofessionals who have strong community knowledge, and case managers who are trained to access formal community services. Two community boards, one focused on promoting inter-agency communication and support to enhance navigators’ effectiveness, and the other focused on implications for state and federal policy, will meet annually with the goal of identifying key findings with the potential to influence local, state, and national priorities for children’s mental health.

PI_NAMEs: ATKINS, MARC STEVEN;MEHTA, TARA  (contact)

PROGRAM_OFFICER_NAME: MARRO, MARY ACRI

PROJECT_TERMS: Accounting;Address;African American;Age;Attitude;barrier to care;Caregivers;Caring;Case Manager;Chicago;Child;Child Care;Child Mental Health;child mental health service;cohort;Communication;Communities;Community Mental Health Services;Community Services;Computerized Medical Record;Consensus;Data;design;disparity reduction;Effectiveness;effectiveness evaluation;Elements;Equation;ethnic disparity;ethnic minority;Familiarity;Family;family support;federal policy;Focus Groups;Goals;Grant;health disparity;health service use;Health Services;Health system;Healthcare;insight;Intake;Knowledge;Latinx;Mediating;Mental Health;mental health policy;Mental Health Services;Methods;Modeling;optimism;Outcome;Parents;patient navigation;patient navigator;Policies;poor communities;Poverty;Procedures;Psyche structure;Public Policy;racial disparity;racial minority;Randomized;Recommendation;recruit;Reporting;Research;Resources;Services;social capital;Social Network;social stigma;Social support;Social Work;success;System;Testing;theories;Training;Transportation;Urban Community;urban poverty;Waiting Lists

PROJECT_TITLE: Patient Navigators for Children's Community Mental Health Services in High Poverty Urban Communities

STUDY_SECTION: SERV

STUDY_SECTION_NAME: Mental Health Services Study Section[SERV]


NIH_SPENDING_CATS: Mental Health;Neurosciences

ORG_CITY: WORCESTER

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: Project Narrative As an organism experiences its world, neural circuits remodel such that a subset of synaptic connections between neurons are removed, while others are maintained and strengthened. The current proposal will shed new light on how glial cells (astrocytes and microglia), another 50% of brain cell types, communicate to selectively remove a subset of synapses, while sparing others. Long-term, these findings have important implications for understanding why some synapses are more susceptible to aberrant removal in a broad range of neuropsychiatric disorders, such as schizophrenia, to neurodegenerative diseases, such as Alzheimer’s disease.

PI_NAMEs: SCHAFER, DOROTHY PATRICIA (contact)

PROGRAM_OFFICER_NAME: TONELLI, LEONARDO HERALDO

PROJECT_TERMS: Ablation;Adult;Age;Alzheimer's Disease;animal old age;Astrocytes;barrel cortex;Brain;brain cell;Cauterize;cell type;Cells;Central Nervous System;Communication;Complement;CX3CL1 gene;Data;density;Development;Disease;Electron Microscopy;Excision;experience;Face;Fractalkine;fractalkine receptor;Funding;Genetic;genetic approach;Goals;Immune;Left;Lesion;Ligands;Macrophage;Maintenance;Maps;Mediating;Microglia;Microscopy;Modeling;Molecular;Mus;neonate;neural;neural circuit;Neurodegenerative Disorders;Neurodevelopmental Disorder;Neuroglia;neuroligin 2;Neurons;neuropsychiatric disorder;neurotransmission;novel;Organism;overexpression;Predisposition;prevent;Process;receptor;Receptor Signaling;Research;response;retinogeniculate;Schizophrenia;Sensory;Shapes;Side;Signal Transduction;Synapses;Testing;Thinking;tool;Touch sensation;transcriptome sequencing;translating ribosome affinity purification and RNA-sequencing;Vibrissae;Vision;WNT Signaling Pathway;Work

PROJECT_TITLE: Microglia-Astrocyte Crosstalk Regulating SynapseRemodeling

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative As you walk, you coordinate movements in your arms and legs. Neurons with long connections up and down the spinal cord are responsible for this coordination. In this proposal, we will map the connections between different types of spinal neurons to understand how local and long-range connections are different. With computational models based on these results, this work will help explain coordination along the spinal cord.

PI_NAMEs: BAGNALL, MARTHA W (contact)

PROGRAM_OFFICER_NAME: OSBORNE, LESLIE CAROL

PROJECT_TERMS: Ablation;Animals;Anterior Horn Cells;arm;Axon;Behavioral;Biological;Biological Assay;Charge;Clinical;Computer Models;Contralateral;Data;dorsal horn;Ensure;Exhibits;experimental study;GATA3 gene;Head;Home;Horns;in vivo;inhibitory neuron;Injury;Ipsilateral;Leg;Locomotion;Logic;Mammals;Maps;Measures;Modeling;Morphology;Motor;Motor Neurons;Movement;Muscle Contraction;Natural regeneration;Neurons;optogenetics;Organism;Output;Pattern;Physiological;Population;Positioning Attribute;postsynaptic;predictive modeling;Publishing;Sensory;Slice;Spinal;Spinal Cord;spinal cord repair;spine bone structure;Stimulus;Structure;Synapses;Synaptic Potentials;Tail;Target Populations;Testing;Translating;V1 neuron;Walking;Whole-Cell Recordings;Work;Zebrafish

PROJECT_TITLE: Longitudinal structure of spinal premotor circuits

STUDY_SECTION: SMN

STUDY_SECTION_NAME: Sensory-Motor Neuroscience Study Section[SMN]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Brain Disorders;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Depression;Dissemination and Implementation Research;Health Services;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Pediatric;Prevention;Primary Health Care;Serious Mental Illness;Sleep Research;Suicide;Suicide Prevention

ORG_CITY: EUGENE

ORG_NAME: KSANA HEALTH, INC.

ORG_STATE: OR

PHR: PROJECT NARRATIVE  Despite efforts to prevent suicide, US rates are climbing, and suicide is the second leading cause of death amongst youth. Digital tools, especially personal smartphones, are promising avenues to address these issues and can be used to provide a unique understanding of proximal risk factors, including psychological distress, anhedonia and behavioral withdrawal, and sleep disturbance amongst high-risk individuals. This Fast-Track SBIR proposal will enhance the effectiveness of the delivery of preventative health care to youth at risk for suicide by developing and testing a comprehensive digital platform that allows practitioners to integrate objective mobile sensing and HIPAA compliant client communication tools into their management of these young people.

PI_NAMEs: ALLEN, NICHOLAS B (contact)

PROGRAM_OFFICER_NAME: HAIM, ADAM J

PROJECT_TERMS: 18 year old;Address;Adherence;Administrator;Adolescent;Adoption;Anhedonia;arm;Behavioral;behavioral health;Businesses;care providers;Caring;Cause of Death;Cellular Phone;Child;Client;Clinic;Clinical Management;Clinical Services;Communication Tools;Computer software;Continuity of Patient Care;Data;Development;Devices;digital;digital mental health;digital platform;digital tool;Distal;Effectiveness;effectiveness clinical trial;effectiveness evaluation;electronic health record system;emotional distress;experience;feasibility trial;Feedback;Feeling suicidal;Gatekeeping;Grant;Health;health care service organization;Health Insurance Portability and Accountability Act;Health Services;Healthcare;Healthcare Systems;high risk;high risk population;high-risk adolescents;Hospitals;implementation fidelity;implementation framework;improved;indicated prevention;Individual;Intervention;intervention effect;Licensing;Literature;Medical center;Mental Health Services;Methods;mobile application;mobile sensing;New York;Oregon;Outcome;outpatient programs;Outpatients;Patients;Persons;Phase;Pragmatic clinical trial;Presbyterian Church;Prevention;Prevention approach;Prevention program;Prevention strategy;Preventive healthcare;preventive intervention;Process;Program Evaluation;Psyche structure;psychological distress;Random Allocation;randomized, clinical trials;reducing suicide;Research;research study;Risk;Risk Factors;Risk Reduction;selective prevention;sensor;service delivery;Services;Sleep;Sleep disturbances;Small Business Innovation Research Grant;smartphone application;Source;Special Equipment;Substance Use Disorder;suicidal;suicidal behavior;suicidal risk;Suicide;Suicide prevention;System;Technology;technology development;technology research and development;Technology Transfer;Testing;tool;Training;Transfer Agreement;treatment as usual;United States National Institutes of Health;Universities;usability;user centered design;Withdrawal;Youth

PROJECT_TITLE: Development and testing of a digitally assisted risk reduction platform for youth at high risk for suicide


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Neurosciences;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: PHILADELPHIA

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Narrative The proposed research is relevant to public health, because although memory dysfunction is a frequent and persistent symptom of traumatic brain injury (TBI), there are currently no effective treatments available for this persistent deficit. In addition, the neurophysiological basis of these deficits remains unknown, making rational treatment design difficult. The project is relevant to the NINDS mission because knowledge of why TBI induced memory disorders persist, and how neuromodulation alleviates them in animal models, will allow for clinical treatment development that will reduce the burden of these deficits.

PI_NAMEs: WOLF, JOHN ALLEN (contact)

PROGRAM_OFFICER_NAME: AWWAD, HIBAH OMAR

PROJECT_TERMS: Affect;Animal Model;Animals;Area;Behavioral;behavioral outcome;Brain;Brain region;Clinical Treatment;Code;Cognition;cognitive function;Communication;Complex;Contralateral;Coupling;Data;debilitating symptom;density;design;effective therapy;Electrophysiology (science);Episodic memory;Event;experimental study;Functional disorder;functional restoration;Future;Goals;Hippocampus;Human;improved;Injury;Interneurons;Knowledge;Learning;Measures;Medial;Memory;memory consolidation;Memory Disorders;memory encoding;Memory impairment;memory recall;Mission;National Institute of Neurological Disorders and Stroke;network dysfunction;Neurons;neurophysiology;neuroregulation;novel;Outcome Measure;persistent symptom;Phase;Play;Population;Prefrontal Cortex;Public Health;rational design;Rattus;Research;restoration;Rodent;Series;Short-Term Memory;spatial memory;Structure;therapy design;therapy development;Translating;Traumatic Brain Injury;treatment strategy

PROJECT_TITLE: Network Dysfunction and Neuromodulation following TBI

STUDY_SECTION: BINP

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Breast Cancer;Cancer;Women's Health Research

ORG_CITY: GENT

ORG_COUNTRY: BELGIUM

ORG_FIPS: BE

ORG_NAME: FLANDERS INTERUNIV INST BIOTECHNOLOGY

PHR: NARRATIVE Each year, 50,000 women are diagnosed with ductal carcinoma in situ (DCIS) in the US; and although DCIS is classified as non-invasive, some DCIS will progress to invasive breast cancer. Currently, it is impossible to predict this progression meaning all DCIS patients are treated with the same invasive therapy, causing thousands of women with DCIS to be overtreated and undergo surgery and therapy they do not need. These overtreatment measures risk harmful side effects and add a significant psychological burden to patients, while using valuable resources in healthcare systems. This project aims to identify biomarkers to predict whether DCIS stays non-invasive or becomes invasive and life-threatening by studying the dynamic behavior of DCIS cells using advanced microscopy technologies and labelling techniques.

PI_NAMEs: SCHEELE, COLINDA  (contact)

PROGRAM_OFFICER_NAME: OSSANDON, MIGUEL

PROJECT_TERMS: 3-Dimensional;Bar Codes;Behavior;biobank;Biological Markers;Biological Models;biomarker identification;Breast;Cells;Classification;Clinical;Clinical Pathology;cohort;Collaborations;Data;Disease;Excision;Gene Expression;Generations;Genetic Markers;Gland;Goals;Growth;Healthcare Systems;Heterogeneity;high risk;Histologic;Histopathology;Human;image guided;Imaging Techniques;Imaging technology;In Situ Lesion;Indolent;infiltrating duct carcinoma;Injections;intravital imaging;Invaded;Knowledge;Label;Lesion;Life;Location;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Gland Parenchyma;Manuscripts;Maps;Measures;Metastatic breast cancer;Microdissection;Microscopy;Minority;Modeling;Molecular;molecular subtypes;Morphology;Netherlands;Noninfiltrating Intraductal Carcinoma;novel;Operative Surgical Procedures;Optics;Outcome;overtreatment;patient derived xenograft model;patient population;Patients;Pattern;potential biomarker;Predictive Factor;predictive marker;Prognostic Factor;psychologic;Research;Resolution;Resources;Risk;Sampling;side effect;spatiotemporal;Systemic Therapy;Techniques;Technology;Three-Dimensional Imaging;Time;Tissues;transcriptome sequencing;transcriptomics;Uncertainty;Woman;women's diagnosis

PROJECT_TITLE: Mapping ductal carcinoma in situ in space and time to reveal biomarkers that can predict invasive risk

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-A (O1)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Caregiving Research;Childhood Injury;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Neurosciences;Pediatric;Social Determinants of Health;Violence Research;Youth Violence

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: 2. PROJECT NARRATIVE Though childhood victimization is an endemic phenomenon, our collective knowledge of how and why such experiences translate into enduring mental health difficulties remains stubbornly underdeveloped, particularly in relation to the underlying neural mechanisms. In children, neural maturation of brain function manifests as a progressive reorganization of networked brain regions exhibiting correlated (or anti-correlated) activation, and alterations in this developmental process may be a biomarker of the protective or potentiating effects of ecolog- ical influences such as victimization or parenting practices. Establishment of functional network dynamics and development as a malleable mechanism linking adversity to impairment in transdiagnostic biobehavioral domains (e.g., difficulties with emotion regulation) can inform development of targeted, evidence-based clinical ap- proaches for vulnerable populations of victimized youth.

PI_NAMEs: RUSSELL, JUSTIN D (contact)

PROGRAM_OFFICER_NAME: BECHTHOLT, ANITA JEAN

PROJECT_TERMS: Accounting;Address;Adolescent;Adverse event;Affective;Anterior;Area;Behavior;Behavioral;Big Data;biobehavior;Biological;Biological Markers;Brain;Brain region;career;career development;Caregivers;caregiving;Characteristics;Child;child and adolescent victimization;Child Rearing;Childhood;childhood adversity;Clinical;cognitive development;Cross-Sectional Studies;Data;deep learning;deep learning model;Development;Developmental Process;Diagnostic;Diagnostic Factor;Dimensions;Dorsal;early life adversity;emotion regulation;Emotional;Emotions;Environment;Equation;Evaluation;evidence base;Exhibits;experience;Exposure to;Family;Foundations;functional MRI scan;Future;Goals;Impairment;Influentials;insight;Insula of Reil;Investigation;Knowledge;Limbic System;Link;Machine Learning;Mediating;Mediation;Mediator;Mental disorders;Mental Health;Mentors;Mentorship;Modeling;multimodality;Nature;neural;neural circuit;neural correlate;neural network;Neural Network Simulation;neurobehavioral;neurodevelopment;neuromechanism;neuroregulation;Neurosciences;Outcome;Parents;Pathway Analysis;Pathway interactions;Pattern;Phenotype;predictive modeling;Prefrontal Cortex;Psychiatric therapeutic procedure;Psychiatry;Psychopathology;Research;Research Personnel;Research Project Grants;Rest;Risk;Scientist;skills;Social Development;Source;System;Theoretical model;theories;Time;Training;Translating;trend;Universities;Victimization;Vulnerable Populations;Wisconsin;Work;Youth

PROJECT_TITLE: Impacts of Victimization and Caregiving on the Neurodevelopment of Emotion Regulation

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Aging;Biodefense and Related Countermeasures;Brain Disorders;Cerebrovascular;Emerging Infectious Diseases;Infectious Diseases;Neurosciences;Rare Diseases;Tickborne Diseases;Vector-Borne Diseases

ORG_CITY: STONY BROOK

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

ORG_STATE: NY

PHR: Powassan virus (POWV) is a tick-borne virus that causes a 10% fatal brain disease, and a new tick POWV isolate, LI9, was found to cause highly lethal brain damage in aged mice, a finding that mimics POWV disease in elderly patients. In contrast, an attenuated POWV, LI9-P, fails to cause brain damage in mice and is a potential vaccine that differs in its ability to regulate antiviral responses of cells that form brain barriers. Paired lethal and attenuated POWVs, and our unique ability to modify POWVs, permit us to propose defining determinants and mechanisms of POWV entry into the brain and antiviral interferons as potential inhibitors of brain damage applicable to elderly POWV patients.

PI_NAMEs: MACKOW, ERICH R (contact)

PROGRAM_OFFICER_NAME: ALARCON, RODOLFO M

PROJECT_TERMS: Acute;age related;American;Anti-viral Response;Attenuated;attenuation;Black-legged Tick;Blood - brain barrier anatomy;blood cerebrospinal fluid barrier;Brain;brain control;Brain Diseases;brain endothelial cell;Brain Injuries;C57BL/6 Mouse;Cell-Matrix Junction;Cells;chemokine;Chimera organism;Choroid Plexus Epithelium;Coma;COVID-19 patient;Cytoprotection;Data;Disease;Elderly;emerging virus;Encephalitis;Epithelial Cell Junction;Epithelial Cells;Fever;Health;Hepatitis;Histopathology;Hospitalization;Human;IFNGR1 gene;immune cell infiltrate;immunoregulation;In Vitro;in vivo;Incidence;Infection;Inflammatory;inhibitor;Interferon alpha;Interferon Type II;Interferons;Licensing;Link;Long Island;Mammals;Modeling;mouse model;Mus;mutant;Natural Immunity;Nervous System Trauma;neuroinflammation;neurovascular;neurovirulence;novel;old mice;older patient;Pathology;Pathway interactions;Patients;Peripheral;Phase;Powassan virus;prevent;prophylactic;Proteins;Rationalization;Recombinants;Regulation;repaired;Repression;Respiratory Tract Infections;response;reverse genetics;Role;Seizures;single-cell RNA sequencing;Skin;Slice;Stains;Structure of choroid plexus;System;Therapeutic;Therapeutic Uses;tick bite;tick saliva;tick-borne flavivirus;tick-borne virus;Ticks;Tight Junctions;Vaccines;Vascular Endothelial Cell;Viral;Viral Load result;Virus;Virus Diseases

PROJECT_TITLE: Innate Immune Regulation of Powassan Virus Neurovirulence

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 VDT-Q (01)]


ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Narrative Gut Bacteroides require an array of cell surface lipoproteins to survive in the host, yet how lipoproteins are synthesized in these bacteria is poorly understood. Here we will determine how a newly discovered N- acyltransferase plays a key role in lipoprotein maturation and fitness in the model gut symbiont Bacteroides thetaiotaomicron. This work will reveal molecular details of a conserved lipoprotein synthesis pathway that is unique to Bacteroides and provide new and selective ways to manipulate these host-associated bacteria.

PI_NAMEs: KOROPATKIN, NICOLE M (contact)

PROGRAM_OFFICER_NAME: ERNST, NANCY L

PROJECT_TERMS: Active Sites;Acylation;Acyltransferase;Affect;Alkaline Phosphatase;Architecture;ATP phosphohydrolase;Bacteria;bacterial fitness;Bacteroides;Bacteroides fragilis;Bacteroides thetaiotaomicron;Biochemical;Bioinformatics;Biological Assay;Cell Communication;cell envelope;Cell Shape;Cell surface;cell type;Cells;Cellular Morphology;Co-Immunoprecipitations;Communication;Complement;Coupled;cytokine;Defect;Development;enteric infection;enteric pathogen;Environment;Enzymes;Epithelium;Escherichia coli;experience;fitness;Fractionation;gene conservation;Genes;Genetic;Genetic Screening;genome analysis;Goals;Growth;gut microbiota;Homologous Gene;Human;immune activation;Immune response;Immune system;In Vitro;Interleukin-10;Intestines;Libraries;Lipoproteins;Location;Macrophage;Mass Spectrum Analysis;Measures;Membrane;Membrane Proteins;Microscopy;model organism;Modeling;Molecular;Morphology;mutant;N acylation;novel;novel therapeutics;Nutrient;Pathway interactions;Pattern;Penetration;Phospholipids;Physiology;Play;Polysaccharides;Production;Proliferating;protein structure;Proteins;Quantitative Microscopy;Reporter;Research;Role;Shapes;signal peptidase;Signal Transduction;Structure;Substrate Specificity;Surface;symbiont;Symbiosis;TLR2 gene;Toll-like receptors;tool;trafficking;Transferase;Transmembrane Domain;uptake;Vesicle;Virulence Factors;Visualization;Work

PROJECT_TITLE: Bacteroides use a novel N-acyltransferase for lipoprotein synthesis and survival

STUDY_SECTION: PCMB

STUDY_SECTION_NAME: Prokaryotic Cell and Molecular Biology Study Section[PCMB]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Cardiovascular;Cerebrovascular;Clinical Research;Dementia;Hypertension;Neurodegenerative;Neurosciences;Obesity;Prevention;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE Vascular risk factors (particularly hypertension and obesity) are important contributors to Alzheimer’s disease, working with amyloid pathology in individuals without symptoms to accelerate the buildup of abnormal tau proteins and drive cognitive decline. This study will provide important missing knowledge about how early and over what age range this interaction takes place and therefore can be intervened upon, and whether imaging or blood measures of tau pathology can detect this early and silent partnership between vascular risk and Alzheimer’s disease in midlife. Outcomes from this project will inform the design of prevention trials targeting both amyloid and hypertension or obesity in asymptomatic Alzheimer’s disease, by identifying individuals who are at risk and are most likely to benefit from early intervention, and by determining whether we can use blood measures of tau pathology to improve accessibility and diversity of these clinical trials.

PI_NAMEs: YAU, WAI-YING WENDY (contact)

PROGRAM_OFFICER_NAME: HAAKENSON, CHELSEA MARIE

PROJECT_TERMS: abeta accumulation;Acceleration;Address;Adult;Advisory Committees;Age;age effect;age group;Aging;aging brain;Alzheimer's Disease;Alzheimer's disease risk;Alzheimer’s disease biomarker;Amyloid;Amyloid beta-Protein;amyloid pathology;asymptomatic Alzheimer's disease;Biological Assay;Biological Markers;Blood;Blood Pressure;Blood Vessels;Body mass index;Brain;career;causal model;clinical practice;Clinical Trials;Clinical Trials Design;Cognitive;cohort;cost;critical period;Data;data harmonization;design;Early Diagnosis;Early Intervention;Epidemiology;epidemiology study;Foundations;Framingham Heart Study;Funding;Generations;Goals;Hypertension;Image;Impaired cognition;improved;Individual;innovation;Intervention;K-Series Research Career Programs;Knowledge;late life;Measures;Medial;Mediating;Mediation;Mentored Patient-Oriented Research Career Development Award;Mentorship;Methodology;middle age;multimodality;Neocortex;neocortical;Neurologist;novel;Obesity;Outcome;Parietal;Participant;Pathogenesis;Pathologic;Pathology;Physicians;Pittsburgh Compound-B;Plasma;Populations at Risk;Positron-Emission Tomography;pre-clinical;Prevalence;Prevention;Prevention trial;prospective;Research;research study;Risk;Scientist;sex;skills;Statistical Methods;Surrogate Endpoint;Symptoms;synergism;tau aggregation;tau mutation;tau Proteins;tau-1;Tauopathies;Techniques;Testing;Therapeutic;therapeutic target;Training;Translating;United States National Institutes of Health;vascular cognitive impairment and dementia;vascular contributions;vascular risk factor;Work;β-amyloid burden

PROJECT_TITLE: Elevated systolic blood pressure, body mass index, and amyloid as drivers of tau and cognitive decline in preclinical Alzheimers disease: critical windows in mid- to late-life

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development for Clinicians/Health Professionals Study Section [AGCD-3]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Digestive Diseases;Neurosciences;Nutrition;Obesity;Prevention

ORG_CITY: DURHAM

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE The objective of the proposed mentored research career development award is to facilitate the transition of the application to an independent scientist career investigating the physiologic processes regulating food intake to better treat obesity. The proposed studies will identify the role of a specialized sensory cell in the small intestine in reward-driven food intake and obesity. These studies will provide a novel therapeutic site for obesity treatment.

PI_NAMEs: RUPPRECHT, LAURA ELOISE (contact)

PROGRAM_OFFICER_NAME: CUMMINGS, DIANA M

PROJECT_TERMS: American;Anti-Obesity Agents;Automobile Driving;Behavior;behavior test;Behavioral Assay;behavioral response;Body Weight;Brain;Brain Stem;Bypass;Calories;career;Cells;Cessation of life;Cholecystokinin;Chronic;conditional knockout;Consumption;Data;design;Desire for food;Diet;Dopamine;dopaminergic neuron;drug action;Duodenum;Eating;Esthesia;experience;experimental study;Fatty acid glycerol esters;feeding;Feeding behaviors;Feeling;Fiber;Food;food consumption;Food Intake Regulation;Gastroenterology;gastrointestinal epithelium;glutamatergic signaling;Glutamates;Goals;gut endocrine cell;Health;Hormones;Hyperphagia;Ingestion;Intestines;K-Series Research Career Programs;Knock-out;Knockout Mice;Label;Link;Maps;Measures;Mediating;Mentored Research Scientist Development Award;Mentors;Metabolic Diseases;Metabolism;Midbrain structure;millisecond;Modeling;mouse model;Mus;Nature;neural;Neurons;Neurosciences;Neurotransmitters;novel;novel therapeutics;Nutrient;obese patients;Obesity;obesity prevention;obesity treatment;optogenetics;Persons;Pharmacologic Substance;Pharmacotherapy;Physiological;Physiological Processes;pleasure;Positioning Attribute;Positive Valence;preference;promoter;Reporting;Research;Research Personnel;Rewards;Role;Scientist;sensor;Sensory;side effect;Signal Transduction;Simplexvirus;Site;Small Intestines;Stimulus;sugar;Sweetening Agents;Synapses;Taste Perception;Training;United States;United States National Institutes of Health;Weight Gain;Weight maintenance regimen;wireless;Work

PROJECT_TITLE: Gut epithelial control of nutrient reward

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Genetics;Hematology;Human Genome;Lymphatic Research;Lymphoma;Prevention;Rare Diseases;Skin Cancer

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Narrative Lack of specific markers for malignant lymphocytes prevents early diagnosis of mycosis fungoides (MF), the most common subtype of cutaneous T-cell lymphomas. This proposal investigates the potential for IL13Rα1 expression by T cells in the diagnosis of early MF, allowing appropriate treatment to be instituted, benefiting disease management over many years, and greatly improving quality of life in this debilitating disease

PI_NAMEs: FUSCHIOTTI, PATRIZIA  (contact);GESKIN, LARISA J

PROGRAM_OFFICER_NAME: WANG, WENDY

PROJECT_TERMS: Affect;anti-tumor immune response;Antibodies;Atypical lymphocyte;autocrine;Benign;Biopsy;candidate marker;cell type;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Clinical;Clinical Data;clinically relevant;Clonal Expansion;Clone Cells;cohort;Color;Cutaneous;Cutaneous T-cell lymphoma;cytokine;data repository;Development;Diagnosis;Diagnostic tests;Disease;Disease Management;Disease Progression;Early Diagnosis;Evaluation;Exfoliative Dermatitis;Fatal Outcome;Gene Expression;Gene Expression Profile;Histologic;Human;IL-13Ralpha1;Immune;Immunofluorescence Immunologic;Immunohistochemistry;Immunophenotyping;improved;Individual;Indolent;Infiltration;Inflammatory;innovative technologies;Interleukin-13;Invaded;leukemia;lymph nodes;Lymphocyte;Malignant - descriptor;malignant lymphocyte;Malignant Neoplasms;Measures;Methods;Molecular;Mycosis Fungoides;neoplastic;neoplastic cell;Nodal;Outcome;Pathogenesis;Pathway interactions;Patients;Pattern;peripheral blood;Phase;Population Heterogeneity;prevent;Production;Prognostic Marker;Proliferating;prospective;Quality of life;receptor;repository;Resolution;Running;Sampling;Signal Transduction;Site;Skin;skin disorder;skin lesion;Skin Neoplasms;STAT6 Transcription Factor;Survival Rate;Symptoms;T-Lymphocyte;Testing;Time;tissue resident memory T cell;transcriptome;tumor;tumor microenvironment;tumorigenesis;Visceral;Work

PROJECT_TITLE: Develop IL13Ra1 for diagnosis of early-stage mycosis fungoides

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-K (O1)]


ADMINISTERING_IC: LM

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Networking and Information Technology R&D (NITRD);Patient Safety;Rural Health;Social Determinants of Health

ORG_CITY: SALT LAKE CITY

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Not Applicable. Not part of the original application or solicitation.

PI_NAMEs: JARVIS, CHRISTY  (contact)

PROGRAM_OFFICER_NAME: YOON, SUNG SUG

PROJECT_TERMS: Academic Medical Centers;access disparities;Access to Information;Address;Affect;Area;Caring;Clinical;clinical care;clinical decision support;clinical decision-making;clinical practice;Collection;Communities;Competence;cost;Data;Decision Making;Democracy;Disparity;disparity reduction;evidence base;Evidence based practice;experience;Feedback;Geography;Goals;Health;health care availability;Health Care Costs;health disparity;health disparity populations;Health Personnel;Health Science Library;Hospitals;improved;improved outcome;Information Resources;Journals;Licensing;Literature;Location;marginalization;Medical;Medical Libraries;Medication Errors;Nature;Operative Surgical Procedures;Outcome;Participant;Pathway interactions;Patient Care;Patient Preferences;patient safety;Patient-Focused Outcomes;Patients;peer;Peer Review;Persons;Physicians;preference;Prevalence;Problem Solving;Provider;Publishing;PubMed;Race;Reporting;Research;Research Design;Resources;Rural;rural area;rural setting;service delivery;socioeconomics;Source;Stratification;Surveys;Text;underserved area;United States National Library of Medicine;Universities;Unnecessary Surgery;usability;Utah;Variant;Workplace

PROJECT_TITLE: Reducing Disparities in Physician Access to Information in Support of Evidence-Based Practice

STUDY_SECTION_NAME: Special Emphasis Panel[ZLM1 ZH-G (01)]


ADMINISTERING_IC: HL

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Congenital Heart Disease;Heart Disease;Pediatric;Rare Diseases

ORG_CITY: GAINESVILLE

ORG_DEPT: NUTRITION

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Project Narrative Cardiac arrhythmias (abnormal heart rhythms) remain a leading cause of death in the United States in part due to abnormal calcium cycling in the heart. This project seeks to gain new insights into how mitochondria impact calcium cycling to contribute to arrhythmogenesis. Information learned from these studies will provide useful guidelines for the development of new therapies for the treatment of heart disorders, especially calcium- dependent arrhythmias.

PI_NAMEs: LIU, BIN  (contact)

PROGRAM_OFFICER_NAME: BALIJEPALLI, RAVI C

PROJECT_TERMS: Ablation;absorption;Animals;Anti-Arrhythmia Agents;Arrhythmia;Biological Assay;Buffers;Calcium;Cardiac;Catecholaminergic Polymorphic Ventricular Tachycardia;Cause of Death;Cell Death;Cell Physiology;Complex;Data;Defect;Dependovirus;design;Development;disease model;disease phenotype;Gene Transfer;Genetic;genetic approach;Guidelines;Heart;Heart Abnormalities;Heart Diseases;Heart failure;heart rhythm;Homeostasis;Hyperactivity;in vivo;inorganic phosphate;insight;Learning;Link;Literature;Mediating;Membrane;Metabolic;Methods;Mitochondria;Modeling;Molecular;mouse model;Muscle Cells;Mutation;Myocardial dysfunction;novel;novel therapeutics;overexpression;Pathologic;Pathology;pharmacologic;Play;Post-Translational Protein Processing;Process;Production;Protein Biochemistry;Proteins;Reactive Oxygen Species;Role;Ryanodine Receptor Calcium Release Channel;Sarcoplasmic Reticulum;Shapes;Signal Transduction;Syndrome;Testing;therapy development;Translating;United States;uptake;Work

PROJECT_TITLE: Role of SR-mitochondria interplay in calcium-dependent arrhythmias

STUDY_SECTION: MPPB

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology B Study Section[MPPB]


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Brain Disorders;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Depression;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Mental Illness;Patient Safety;Pediatric;Precision Medicine;Racial and Ethnic Minority Health Research;Social Determinants of Health;Suicide

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE: Despite high and rising rates of adolescent depression and suicidal thoughts and behaviors, racial and ethnic minoritized (REM) youth are significantly less likely to remain in mental health services than their White peers. Measurement-based care (MBC) is an evidence-based practice that holds promise to promote mental health treatment engagement, but has not been tailored for REM youth. Scientific discovery about how to retain REM youth with depressive symptoms and/or suicide risk in treatment by using a culturally-tailored approach to MBC could reduce disparities in mental health treatment access and outcomes, reducing suffering among this vulnerable population.

PI_NAMEs: ARORA, PRERNA ;CONNORS, ELIZABETH HALSTED (contact)

PROJECT_TERMS: active control;Address;Administrator;adolescent patient;Age;Attitude;Caregivers;Caring;child depression;Clinic;Clinical;Clinical Protocols;Clinical Services;Cognitive;Communities;Consultations;cultural competence;Data;depressive symptoms;design;Development;Disparity;disparity reduction;Dropout;Effectiveness;effectiveness/implementation hybrid;ethnic minority;Evidence based practice;expectation;experience;Feedback;Feeling suicidal;Future;Goals;Guidelines;health care delivery;Health Services Accessibility;hybrid type 2 trial;improved;improved outcome;inclusion criteria;innovation;instrumentation;Intervention;Knowledge;Measurement;Measures;Mental Depression;Mental Health;Mental health promotion;Mental Health Services;minority children;Modeling;National Institute of Mental Health;Outcome;patient oriented;Patient-Focused Outcomes;Patients;peer;personalized approach;personalized medicine;pilot test;Population;premature;Preparation;primary outcome;Procedures;Progress Reports;Protocols documentation;prototype;Public Health;Quality of Care;racial minority;Randomized;recruit;Research;Risk;secondary outcome;Services;Site;skills;suicidal;suicidal adolescent;suicidal behavior;suicidal risk;Suicide;suicide rate;targeted treatment;Testing;Therapeutic;Time;Training;Training Support;treatment as usual;treatment disparity;treatment optimization;Treatment outcome;treatment planning;usability;user centered design;Vulnerable Populations;Youth

PROJECT_TITLE: Strategic Treatment Assessment with Youth (STAY): A measurement-based care approach to promote treatment retention among racial and ethnic minoritized youth with depression or suicide risk


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Biotechnology;Brain Disorders;Clinical Research;Genetics;Human Genome;Mental Health;Mental Illness;Neurosciences;Pediatric;Prevention

PHR: PROJECT NARRATIVE Externalizing disorders are a leading cause of morbidity and mortality in the United States, and the development of novel prevention and therapeutic intervention efforts for these illnesses will require a deeper understanding of their etiological bases. Motivated by recent discoveries implicating early life as a critical risk window, the proposed research will characterize the developmental neurogenomic pathways that confer liability for externalizing psychopathology by combining cutting-edge methods from genomics, neuroscience, and informatics. Findings will provide an integrated, systems-level understanding of the complex molecular underpinnings of externalizing disorders, thus laying the foundation for improved risk stratification, drug discovery, and other translational efforts.

PI_NAMEs: MALLARD, TRAVIS T (contact)

PROGRAM_OFFICER_NAME: VAN'T VEER, ASHLEE VICTORIA

PROJECT_TERMS: Adolescence;Advisory Committees;Affect;Architecture;Atlases;Attention deficit hyperactivity disorder;Award;base;behavioral disinhibition;biobank;Bioinformatics;Biological;Biological Process;Biology;Brain;brain tissue;career;causal variant;Childhood;Clinical;Clinical Data;Clinical Psychology;cognitive development;Communities;Complex;Complex Genetic Trait;Conduct Disorder;cost;Data;Data Set;Development;Diagnosis;Diffusion Magnetic Resonance Imaging;Dimensions;Disease;drug discovery;early adolescence;effective therapy;Environment;Equation;Etiology;experience;Fostering;Foundations;functional genomics;Future;Gene Cluster;Genes;Genetic;genetic architecture;Genetic Predisposition to Disease;Genetic Risk;Genetic study;genome wide association study;genomic locus;Genomics;Genotype;Goals;Heritability;Human;imaging genetics;improved;Individual;Informatics;insight;Jordan;K-Series Research Career Programs;knowledge translation;Life;Link;Mental disorders;Mentorship;Methods;Modeling;Molecular;Morbidity - disease rate;morphometry;mortality;multiple omics;Nature;Neuroanatomy;Neurobiology;neurodevelopment;neurogenomics;Neurosciences;novel;Outcome;Pathway interactions;Pattern;phenome;phenomics;Phenotype;pleiotropism;prenatal;preventive intervention;Process;programs;Psychiatry;psychogenetics;Psychopathology;Qualifying;Research;Resources;Risk;risk stratification;risk variant;Scientist;software development;Spatial Distribution;Statistical Methods;Structure;Substance Use Disorder;System;Technical Expertise;Therapeutic;Therapeutic Intervention;therapeutically effective;Training;training opportunity;Training Programs;trait;transcriptomics;United States;Work

PROJECT_TITLE: Understanding developmental neurogenomic mechanisms in externalizing disorders

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


ORG_DEPT: PATHOLOGY

PHR: PROJECT NARRATIVE Although cancer immunotherapy has drastically changed the course of the disease and favored a durable remission in many patients, some tumors remain resistant to immunotherapy. We propose to study a novel target for cancer immunotherapy called ILT3 (LILRB4) that is highly enriched in macrophages that infiltrate the tumor. Since ILT3 inhibits macrophages, we have developed a blocking antibody that will release macrophages from inhibition, promoting their response and tumor regression.

PI_NAMEs: COLONNA, MARCO  (contact)

PROGRAM_OFFICER_NAME: SINGH, ANJU

PROJECT_TERMS: anti-CTLA4 antibodies;anti-PD-1;anti-tumor immune response;Antibody Therapy;Applications Grants;Area;Bacterial Artificial Chromosomes;Binding;Blocking Antibodies;cancer immunotherapy;cancer type;Cause of Death;Cell Physiology;Cells;checkpoint therapy;Chromosome 19;Clinic;Clinical;Data;Dendritic Cells;design;Disease;Disease remission;Distant;draining lymph node;Engraftment;Exploratory/Developmental Grant;Extracellular Matrix;Fibronectins;Flow Cytometry;Foundations;Genes;Homologous Gene;Human;Human Chromosomes;Immune;immune activation;Immune response;Immunohistochemistry;Immunological Models;Immunooncology;Immunosuppression;Immunotherapy;improved;In Vitro;in vitro Assay;in vivo;in vivo Model;Infiltration;Inflammatory;insight;Knowledge;Laboratories;Large Intestine Carcinoma;Ligands;Lung;Macrophage;Malignant Neoplasms;MC38;Melanoma;Metastatic Neoplasm to the Lung;Modeling;Monoclonal Antibodies;monocyte;Mus;Myeloid Cells;Names;neoplasm immunotherapy;Neoplasm Metastasis;neoplastic cell;novel;Nucleic Acid Regulatory Sequences;Oncology;Patients;Pattern;peripheral blood;personalized medicine;Phagocytes;Phase;Phenotype;Play;predicting response;Primary Neoplasm;Process;Prognosis;programs;receptor;Regulation;Resistance;response;Rhabdomyosarcoma;Role;Sampling;Sarcoma;single-cell RNA sequencing;Site;standard care;T-Cell Activation;T-Lymphocyte;telomere;Testing;Therapeutic Agents;therapeutic target;Time;Tissues;Transgenic Mice;tumor;tumor growth;Tumor Immunity;tumor microenvironment;Tumor Promotion;Tumor Tissue;Tumor-associated macrophages;tumor-immune system interactions;Tumor-infiltrating immune cells

PROJECT_TITLE: ILT3 (LILRB4) in anti-tumor immunity and immunotherapy


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Aging;Breast Cancer;Cancer;Immunotherapy;Prevention;Women's Health Research

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: Project Narrative  New strategies to prevent breast cancer are urgently needed because: i) breast cancer incidence rates keep rising by half percent per year and about 13%, or 1 in 8, of US women are going to develop invasive breast cancer in their life time; ii) prevention strategies for estrogen receptor-positive breast cancer do not reduce patient mortality and prevention strategy for estrogen receptor-negative breast cancer is still not available. Our proposed study aims to intercept breast cancer development by reinforcing antitumor immune response via H1-antihistamines, many of which are over-the-counter drugs to treat seasonal allergies. If the results are promising, our findings could be rapidly translated into clinic trials for immunoprevention of breast cancer, especially, in women at high-risk.

PI_NAMEs: XIAO, YI  (contact);YU, DIHUA

PROGRAM_OFFICER_NAME: VLAD, ANDA MIOARA

PROJECT_TERMS: Address;American Society of Clinical Oncology;anti-tumor immune response;Antihistamines;Blood;Breast Cancer Model;Breast Cancer Patient;Breast Cancer Prevention;Breast Epithelial Cells;Cancer Burden;cancer cell;Cancer Control;Cancer Etiology;cancer immunotherapy;cancer initiation;cancer prevention;cancer type;Cell Physiology;Cells;Cessation of life;chemotherapy;Clinic;Clinical;cohort;cost effective;cytotoxic;cytotoxic CD8 T cells;Data;Death Rate;Development;Early Intervention;Electronic Health Record;Endocrine;Estrogen receptor negative;Estrogen receptor positive;Estrogen Receptors;Exclusion;Functional disorder;Genetically Engineered Mouse;Granzyme;Guidelines;High Risk Woman;Histamine;Histamine H1 Receptors;hormone therapy;imaging system;Immune;immune cell infiltrate;immune-related adverse events;Immunity;Immunologic Surveillance;Immunoprevention;Immunotherapy;improved;Incidence;Intercept;Intervention;Knock-out;Life;Link;Macrophage;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Neoplasms;Mediating;Medicine;Modeling;mortality;mouse model;Mus;neoantigens;Non-Prescription Drugs;novel strategies;Operative Surgical Procedures;Outcome;Patients;Plasma;Play;Population;pre-clinical;prevent;Prevention;Prevention strategy;preventive intervention;Primary Prevention;progesterone receptor positive;Progesterone Receptors;Publishing;Radiation therapy;Raloxifene;Recurrence;Recurrent tumor;Regimen;response;restraint;Role;Safety;seasonal allergies;side effect;Stains;T-Lymphocyte;Tamoxifen;targeted agent;Testing;theories;Time;Translating;treatment response;triple-negative invasive breast carcinoma;tumor;Tumor Immunity;Tumor stage;Tumor Tissue;tumor-immune system interactions;United States;University of Texas M D Anderson Cancer Center;uptake;Woman;Women's mortality

PROJECT_TITLE: Exploring new strategy for breast cancer immunoprevention by targeting histamine receptor H1


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Comparative Effectiveness Research;Cost Effectiveness Research;Diabetes;Health Services

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: PROJECT NARRATIVE Innovative diabetes technologies may offer substantial benefits to older adults with diabetes, yet they remain underutilized. This proposal seeks to generate high-quality, real-world evidence for the use of continuous glucose monitoring (CGM) in adults ≥65 years with diabetes requiring insulin. The study will leverage medical record data linked to Medicare claims to (1) describe patterns of CGM use in routine care; (2) characterize the clinical effects of long-term use; and (3) evaluate the economic impacts of scaling CGM in this age group, propelling new strategies to increase uptake and realize the benefits of CGM for older adults.

PI_NAMEs: KAHKOSKA, ANNA RACHEL (contact)

PROGRAM_OFFICER_NAME: SALIVE, MARCEL

PROJECT_TERMS: Address;Adoption;Adult;age group;Aging;Award;Blood Glucose;Calibration;Cardiovascular Diseases;career;Caring;Caucasians;Characteristics;Chronic Disease;Clinical;clinical effect;cohort;Complement;Complex;Continuous Glucose Monitor;cost;cost effectiveness;cost estimate;cost-effectiveness evaluation;cost-effectiveness ratio;Dangerousness;Data;Data Linkages;Data Sources;Databases;Dehydration;Devices;diabetes management;Diabetes Mellitus;Drops;economic evaluation;economic impact;Economic Models;Economics;Effectiveness;Elderly;Electronic Health Record;Eligibility Determination;Emerging Technologies;Endocrinology;Event;evidence base;experience;falls;frailty;Funding;Future;Geriatrics;Glucose;glucose monitor;Glycosylated hemoglobin A;Goals;Guidelines;Health;health care service utilization;health service use;Health system;Healthcare;Hospitalization;human old age (65+);Hypoglycemia;Impaired cognition;improved;incremental cost-effectiveness;Infection;innovation;insight;Insulin;Insulin-Dependent Diabetes Mellitus;insurance claims;K-Series Research Career Programs;Length;Life;Link;Literature;Long-Term Effects;Longevity;Medical Records;medical specialties;Medical Technology;Medicare;Medicare claim;Mentored Research Scientist Development Award;Mentorship;Methods;Modeling;Morbidity - disease rate;mortality;multiple chronic conditions;Non-Insulin-Dependent Diabetes Mellitus;North Carolina;Notification;older adult;Older Population;Outcome;Patient Care;Patient Selection;Patients;Pattern;Pharmacoepidemiology;Policies;Population;Positioning Attribute;prevent;Provider;Quality of life;Quality-Adjusted Life Years;randomized, clinical trials;Recurrence;Registries;Research;Research Infrastructure;Resources;Risk;routine care;Safety;Sampling;skills;social health determinants;standard of care;Subgroup;System;Technology;technology intervention;Testing;Time;Training;training opportunity;Translations;type I and type II diabetes;Underrepresented Populations;Universities;uptake;Work;World Health;young adult

PROJECT_TITLE: Building a Real-World Evidence Base for Continuous Glucose Monitoring in Older Adults with Diabetes

STUDY_SECTION_NAME: Career Development For Early Career Investigators Study Section [AGCD-2]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Diabetes;Heart Disease;Nutrition;Precision Medicine;Prevention

ORG_CITY: BOSTON

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: PROJECT NARRATIVE People spend most waking time within a few hours of eating, and how efficiently the body metabolizes nutrients is an emerging marker of overall health. We will study the blood’s chemical response to a standardized meal that was administered to a large population of individuals in a community setting. Our research may offer novel biological insights into the body’s response to food that will spur future work in precision nutrition.

PI_NAMEs: MI, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: SMITH, SHARON M

PROJECT_TERMS: Accounting;acylcarnitine;Aftercare;Age;Award;Bile Acids;biobank;Biochemical;Bioinformatics;Biological;Biometry;Blood;Cardiometabolic Disease;cardiometabolic risk;cardiometabolism;Cardiomyopathies;Cardiovascular Diseases;cardiovascular disorder prevention;cardiovascular disorder risk;career;career development;Cessation of life;Chemicals;Cities;Clinical;cohort;Communities;community setting;Continuous Glucose Monitor;Development;Diabetes Mellitus;Disease;Disease Marker;disorder risk;Dyslipidemias;Eating;EFRAC;Epidemiology;ethnic diversity;Failure;Fasting;Food;Framingham Heart Study;Functional disorder;Future;Genetic;Genetic Determinism;genomic data;Genomics;Glucose;Goals;Health;Heart failure;Homeostasis;Hospitals;Hour;Human;human data;Human Genetics;improved;improved outcome;Individual;individual response;inhibitor;inhibitor therapy;insight;Insulin Resistance;International;Investigation;Kansas;Keto Acids;Liquid Chromatography;Measurement;Measures;Mendelian randomization;Mentors;Metabolic;Metabolic dysfunction;metabolic phenotype;Metabolism;metabolomics;Methods;Modification;mortality;Nonesterified Fatty Acids;novel;novel marker;Nutrient;nutrition;Nutritional Science;Obesity;Participant;patient oriented research;Patients;Persons;Phenotype;Physiological;Pilot Projects;Population;population based;precision nutrition;Prediabetes syndrome;premature;Preparation;preservation;Preventive;pro-brain natriuretic peptide (1-76);prospective;Publishing;Questionnaires;Race;racial diversity;Records;recruit;Regulation;Research;Research Personnel;response;Rest;Risk Factors;routine care;Sampling;Scientist;Severity of illness;sex;skills;Sodium;Standardization;symporter;tandem mass spectrometry;Techniques;Technology;Testing;theories;Time;Training;trait;Translating;translational physician;Triglycerides;Unhealthy Diet;Variant;Walking;Work

PROJECT_TITLE: Mixed meal tolerance test elicited metabolite responses as novel markers of cardiometabolic risk

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-G (O1)]


ORG_CITY: VALHALLA

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: NEW YORK MEDICAL COLLEGE

PHR: Narrative Ultra-high dose rate radiation therapy has the potential to reduce the radiation damage seen in normal tissues, but most studies have been done with mice with the delivered plan drastically different from that in clinical treatments. The main goals of this study are to develop treatment planning system for the Mobetron® FLASHIQ for clinical and advanced FLASH-RT planning and evaluation, with deliveries validated via UHDR dosimetry for realistic cases. This study will advance the state-of-the-art in FLASH-RT by bridging the extensive gap between the basic science of FLASH and the clinical needs of FLASH for translation to human trials.

PI_NAMEs: ZHANG, RONGXIAO  (contact)

PROGRAM_OFFICER_NAME: OBCEMEA, CEFERINO H

PROJECT_TERMS: 3-Dimensional;Address;Anatomy;Animal Model;Animals;Basic Science;beamline;Biological Assay;Brain;Breast;cancer therapy;Canis familiaris;Clinical;clinical research site;clinical translation;Clinical Treatment;clinically relevant;Colon;commercialization;Communities;Complication;Computer software;conventional therapy;Cutaneous Lymphoma;Data;design;Development;Dose;Dose Rate;dosimetry;Effectiveness;electron energy;Electrons;Evaluation;Exploratory/Developmental Grant;field study;Fostering;Fractionation;Future;Geometry;Goals;Grant;high risk;Human;Industrialization;Informatics;insight;Interruption;invention;irradiation;Lung;Melanoma;Modeling;Monte Carlo Method;Mus;Nature;Normal tissue morphology;Organ;Penetration;phenomenological models;Photons;Physiologic pulse;pilot trial;pre-clinical;preclinical study;Probability;Protons;prototype;quality assurance;Radiation;radiation delivery;Radiation induced damage;Radiation Oncology;Radiation Physics;Radiation therapy;Radiation Toxicity;radioresistant;Research;Resources;response;Risk;Running;simulation environment;Site;Skin;Soft tissue sarcoma;Statistical Models;Structure;System;Technology;Therapeutic;Therapy Clinical Trials;Time;Tissues;translation to humans;translational study;Translations;treatment optimization;treatment planning;tumor;Tumor Tissue;Work

PROJECT_TITLE: Treatment Planning System for Electron FLASH radiation therapy

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-X (O1)]


NIH_SPENDING_CATS: Autoimmune Disease;Bioengineering;Data Science;Digestive Diseases;Genetics;Human Genome;Inflammatory Bowel Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

PHR: Project Narrative Cell-cell interaction plays a crucial role in many biological processes, including cell differentiation, inflammation, wound repair and oncogenesis. Current methods for identifying cell-cell interactions are mainly through low-throughput manual techniques, leaving a disconnect between advancements in high-throughput methods and the identification of biologically meaningful interactions. This proposal aims to bridge this gap by creating computational frameworks that comprehend the impact of external signals on a cell's internal transcription factor activity using a combination of single-cell multiome and spatial transcriptomics data.

PI_NAMEs: CHU, TIN YI  (contact)

PROGRAM_OFFICER_NAME: GILCHRIST, DANIEL A

PROJECT_TERMS: Address;Adult;Affect;Algorithms;Benchmarking;Biological;Biological Process;Cell Communication;Cell Count;Cell Differentiation process;Cell model;cell type;Cells;Chromatin;Communities;Complex;computer framework;Computer Models;Computing Methodologies;Data;deep learning model;Disease;DNA Sequence;Epigenetic Process;Event;Gene Expression;Genes;Genetic Transcription;Genomics;Goals;Heterogeneity;improved;Individual;Inflammation;Inflammatory Bowel Diseases;Infrastructure;insight;Intestines;Learning;learning strategy;Ligands;Manuals;Maps;Mentors;Methods;Modeling;Multiomic Data;multiple omics;Natural Language Processing;new therapeutic target;novel;Performance;Phase;physical separation;Play;Prevalence;Proteins;receptor;Receptor Cell;Regulatory Element;Research;Resolution;Role;Series;Signal Transduction;single-cell RNA sequencing;Spatial Distribution;Techniques;Testing;Tissues;tool;transcription factor;transcriptome sequencing;transcriptomics;tumorigenesis;Work;wound healing;XCL1 gene

PROJECT_TITLE: Computational Modeling of the Interplay between External Signaling and Transcription Rewiring using Spatial Transcriptomics and Single Cell Multiome Data

STUDY_SECTION_NAME: Genome Research Study Section[GNOM-G]


NIH_SPENDING_CATS: Biotechnology;Gene Therapy;Genetics;Neurodegenerative;Neurosciences;Orphan Drug;Pediatric;Rare Diseases;Spinal Muscular Atrophy

PHR: Narrative Despite all progress in the neuromuscular field, there is no permanent cure for spinal muscular atrophy (SMA), and all current available therapies have important limitations. This study will develop strategies to permanently edit the SMN2 gene to produce full-length Survival Motor Neuron (SMN) protein by applying CRISPR technologies. The study will provide pre-clinical evidence towards the development of a lasting single-dose genetic treatment for SMA.

PI_NAMEs: ALVES, CHRISTIANO  (contact)

PROGRAM_OFFICER_NAME: NUCKOLLS, GLEN H

PROJECT_TERMS: Address;Alternative Splicing;Antisense Oligonucleotides;base editing;base editor;career;career development;Collaborations;Communities;CRISPR/Cas technology;Data;Dependovirus;Development;Disease;DNA;Dose;efficacy evaluation;exon skipping;Exons;experimental study;Family;Future;gene replacement;Genes;Genetic;genome editing;Goals;Health;Human;improved;in vivo;Infant Mortality;Injections;International;Knowledge;Laboratories;Laboratory Research;Length;Life;meetings;Mentored Research Scientist Development Award;Mentors;mouse model;Mus;Mutation;neurogenetics;neuromuscular;Neuromuscular Diseases;Neuromuscular research;novel;novel strategies;novel therapeutics;paralogous gene;Pathologic;Pathway interactions;Patients;Penetrance;Phenotype;Physiology;Positioning Attribute;pre-clinical;Production;programs;protein expression;Research;RNA;Route;Severities;skills;small molecule;SMN protein (spinal muscular atrophy);SMN1 gene;SMN2 gene;Spinal Muscular Atrophy;success;symposium;System;Technology;Therapeutic;Tissues;Training Activity;Transcript;transcriptome;Translational Research;Work;Writing

PROJECT_TITLE: Development of in Vivo Base Editing as a Genetic Treatment for Spinal Muscular Atrophy

STUDY_SECTION: NST

STUDY_SECTION_NAME: Neurological Sciences Training 3 Study Section[NST-3]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Mental Illness;Neurosciences;Physical Activity;Post-Traumatic Stress Disorder (PTSD);Prevention;Social Determinants of Health;Violence Research

ORG_CITY: LEXINGTON

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: Project Narrative The proposed project would explore the viability of moderate intensity exercise, delivered following exposure therapy, as a novel means of enhancing consolidation of therapeutic safety learning and exposure therapies. This knowledge has the potential to increase therapy outcomes for patients with PTSD and related disorders.

PI_NAMEs: ADAMS, THOMAS G;BADOUR, CHRISTAL L. (contact);CISLER, JOSHUA M

PROGRAM_OFFICER_NAME: TUMA, FARRIS KEITH

PROJECT_TERMS: Acute;Adult;Aerobic Exercise;Affective;Aftercare;Amygdaloid structure;Animal Model;Anterior;Anxiety;anxiety reduction;anxious;Arousal;Biological Markers;Brain-Derived Neurotrophic Factor;candidate marker;Cardiovascular Diseases;Clinical assessments;comorbidity;Cues;data modeling;design;Diagnosis;Disease;Dorsal;Emotional;Event;Exercise;exercise intensity;Exercise Test;Exposure to;Extinction;follow-up;Fright;Functional Magnetic Resonance Imaging;Heart Rate;heart rate monitor;improved;indexing;Insula of Reil;Interpersonal Violence;Intervention;Knowledge;Learning;learning extinction;Magnetic Resonance Imaging;Measures;Mediating;Memory;Mental Depression;Monitor;neural;neural circuit;Neurobiology;novel;Participant;Patient-Focused Outcomes;Peripheral;Phase;Physical Exercise;Post-Traumatic Stress Disorders;prevent;Psyche structure;psychoeducation;psychologic;Psychopathology;Psychophysiology;Psychotherapy;Publishing;Randomized;reduce symptoms;Reporting;Safety;self-reported anxiety;Signal Transduction;Symptoms;Testing;Therapeutic;therapy outcome;Trauma;trauma exposure;traumatic event;treadmill;treatment planning;violence exposure;Visit;Walking;Writing

PROJECT_TITLE: Using Exercise to Enhance Consolidation of Exposure-Based Therapeutic Learning in PTSD

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-N (06)]


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Immunotherapy;Women's Health Research

ORG_CITY: LITTLE ROCK

ORG_NAME: UNIV OF ARKANSAS FOR MED SCIS

ORG_STATE: AR

PHR: PROJECT NARRATIVE Understanding the tumor-specific interactions that stimulate macrophages to adopt a tumor-supportive phenotype will enhance the development of novel approaches for creating a tumor-hostile environment that attenuates cancer malignancy. The proposed studies will demonstrate that the interaction of tumor-specific molecules with specific macrophage receptors induces a tumor-supportive phenotype. In addition, the studies will establish the therapeutic utility of blocking these interactions using preclinical models of breast cancer.

PI_NAMEs: KARBASSI, BEHJATOLAH MONZAVI;POST, STEVEN  (contact)

PROGRAM_OFFICER_NAME: SOMMERS, CONNIE L

PROJECT_TERMS: 4T1;Acceleration;Adopted;aggressive breast cancer;Animal Model;antagonist;anti-PD-1;anti-tumor immune response;Antibodies;Antigen Presentation;Antitumor Response;Attenuated;Binding;Biological Markers;Breast Cancer Cell;Breast Cancer cell line;Breast Cancer Model;Breast Cancer Patient;breast cancer progression;Cells;Clinical Trials;cytokine;Data;Development;Effectiveness;Environment;Excision;Exhibits;experimental study;Flow Cytometry;Gene Expression Profiling;Goals;Growth;Immune;immune activator;immune cell infiltrate;Immune checkpoint inhibitor;Immune response;Immune Targeting;Immunosuppression;improved;Infiltration;Inflammatory;innovation;Interleukin-10;Knockout Mice;Ligand Binding;Ligands;Macrophage;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Neoplasms;Mass Spectrum Analysis;Mediating;Metastatic Neoplasm to the Lung;Monoclonal Antibodies;mouse model;Mus;Neoplasm Metastasis;novel;novel strategies;orthotopic breast cancer;Palpable;patient prognosis;Pattern recognition receptor;Peptides;Phenotype;polyoma middle tumor antigen;Polysaccharides;Pre-Clinical Model;Primary Neoplasm;Process;Publishing;receptor;response;Role;single-cell RNA sequencing;SR-A proteins;synergism;T-Cell Activation;T-Lymphocyte;targeted treatment;Therapeutic;Therapeutic Intervention;therapeutic target;TNF gene;tumor;Tumor Immunity;tumor microenvironment;tumor progression;Tumor Promotion;Tumor-associated macrophages

PROJECT_TITLE: SR-A as a therapeutic target in breast cancer


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Infectious Diseases;Microbiome;Pediatric

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE Early childhood caries (ECC) is the most common pediatric disease worldwide and a major public health problem in the US. We found that Selenomonas sputigena is strongly associated with ECC and enhance caries severity in vivo, but its role on the disease etiopathogenesis is unclear. This study aims to elucidate how this motile microbe develop biofilms using biophysics/spatial-omics methods and mediate virulence to cause severe caries.

PI_NAMEs: REN, ZHI  (contact)

PROGRAM_OFFICER_NAME: THIRUMANGALATHU, SHOBA

PROJECT_TERMS: Academic Training;Acids;Address;Adhesions;Advisory Committees;Affect;analytical tool;Animal Model;Applications Grants;Area;Award;Bacteria;Biological;biophysical techniques;Biophysics;career;Career Choice;Child;Childhood;Clinical;Clinical Research;cohort;Communication;Communities;Complex;Correlation Studies;cost;Data;Data Analyses;demineralization;dental biofilm;Dental caries;Dental Enamel;Dental Plaque;Dentists;Development;Diet;Diet Habits;Dietary Sugars;Discipline;Disease;early childhood;Etiology;Event;experience;Exposure to;Fluorescent in Situ Hybridization;Foundations;Goals;Grant;Health;improved;In Situ;in vivo;in vivo Model;insight;Integration Host Factors;Knowledge;Knowledge acquisition;Laboratories;Lesion;Link;Liquid substance;Location;Measures;Mediating;Mentors;Metabolism;Methods;Microbe;microbial;Microbial Biofilms;microbial community;microbiome;microbiome research;microbiota;Modeling;Motility;multidisciplinary;multiple omics;National Institute of Dental and Craniofacial Research;oral bacteria;oral biofilm;Oral Microbiology;oral microbiome;Outcome;Pathogenicity;Pathway interactions;Patients;Phase;polymicrobial biofilm;Preschool Child;Preventive;Process;Production;programs;Proliferating;Property;Public Health;Research;Research Training;RNA;Rodent Model;Role;Saliva;Sampling;Scientist;Selenomonas sputigena;Severities;Severity of illness;single-cell RNA sequencing;Site;skills;Solid;spatiotemporal;Streptococcus;Streptococcus mutans;Structure;Sucrose;sugar;Surface;Technical Expertise;Techniques;Time;Tooth structure;tooth surface;Training;transcriptome;transcriptomics;Virulence;Vision;Writing

PROJECT_TITLE: Probing the role of Selenomonas sputigena in supragingival biofilm spatial structuring and virulence

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


ORG_CITY: NEW YORK

ORG_DEPT: UROLOGY

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Project Narrative. This project will determine whether androgen deprivation therapy (ADT) can sensitize bladder cancers to FDA approved immune checkpoint therapies. Our study will also investigate the impact of T cell specific androgen receptor (AR) deletion on tumor progression and response to therapy.

PI_NAMEs: MULHOLLAND, DAVID  (contact)

PROGRAM_OFFICER_NAME: CARDONE, MARCO

PROJECT_TERMS: androgen deprivation therapy;Androgen Receptor;androgen sensitive;Bioinformatics;Biometry;Bladder Neoplasm;cancer infiltrating T cells;Cancer Model;Cancer Patient;cancer recurrence;Carcinogens;Castration;Cell Physiology;Cells;checkpoint therapy;Clinical;Collaborations;Combined Modality Therapy;Data;Disease;Doctor of Medicine;Doctor of Philosophy;Effectiveness;Epithelium;FDA approved;functional status;Genetic;human disease;immune checkpoint blockade;immunological status;immunomodulatory therapies;Immunotherapy;inhibitor;Investigation;Laboratories;Malignant neoplasm of prostate;Malignant neoplasm of urinary bladder;Methods;mouse model;Mus;Neoplasm Metastasis;novel therapeutic intervention;Oncology;Operative Surgical Procedures;Pathologic;Patients;pre-clinical;Pre-Clinical Model;Primary Neoplasm;programmed cell death ligand 1;programmed cell death protein 1;Prostate Cancer therapy;Prostatic Neoplasms;receptor expression;Receptor Signaling;Resistance;Resistance development;response;Role;Site;standard of care;statistics;T-Lymphocyte;targeted agent;Techniques;Testing;Therapeutic;transcriptomics;Translational Research;treatment response;tumor;tumor microenvironment;tumor progression;tumor-immune system interactions;Urology

PROJECT_TITLE: Targeting the Androgen Receptor to Sensitize Bladder Cancer to Immune Check Point Blockade.

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-1 (O2)]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Mental Health

ORG_CITY: Auburn

ORG_NAME: AUBURN UNIVERSITY AT AUBURN

ORG_STATE: AL

PHR: Project Narrative Severe problem behavior (e.g., aggression, self-injury) among individuals with intellectual and developmental disabilities can greatly impair functioning, produce injury, and lead to placement in restrictive settings. Behavior-analytic treatments, which are the current gold standard for reducing severe problem behavior in this population, are predicated on identifying effective and durable reinforcers for use within behavioral interventions. The current proposal will examine a novel method for identifying reinforcers to enhance behavioral interventions by making them more effective and durable in the face of common treatment challenges.

PI_NAMEs: FALLIGANT, JOHN  (contact)

PROGRAM_OFFICER_NAME: OREILLY, JULIA JIAQI

PROJECT_TERMS: Aggressive behavior;Behavior;Behavior Therapy;Behavioral;Behavioral Mechanisms;Behavioral Research;Biological Assay;Clinical;clinical application;common treatment;Complement;Data;design;Development;dimensional analysis;Dimensions;Effectiveness;Eligibility Determination;Ensure;Environment;Event;experience;Healthcare;Impairment;In complete remission;Individual;individualized medicine;Injury;Intellectual functioning disability;Intervention;Knowledge;Mathematics;Measures;Methodology;Methods;Modeling;Motivation;Multivariate Analysis;novel;Pattern;Performance;Persons;Phase;Population;preference;Property;Proxy;Psychological reinforcement;Reaction Time;real world application;Recurrence;Reinforcement Schedule;reinforcer;Research;Research Personnel;response;Satiation;Schedule;Self-Injurious Behavior;Services;severe behavior problem;standard of care;Stimulus;success;System;Technology;theories;Time;Translating;United States;Work

PROJECT_TITLE: Optimizing Dimensions of Reinforcement to Enhance Behavioral Interventions

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics

ORG_CITY: SAN ANTONIO

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

PHR: PROJECT NARRATIVE We propose a novel approach called caspase cleavage targeting chimera (CACTAC) for targeted protein cleavage by recruiting caspases. Protein function can be abruptly stopped by the one-step, CACTAC-induced protein cleavage. CACTACs that target oncoproteins could be developed as potential cancer therapies.

PI_NAMEs: LYU, DONGWEN  (contact)

PROGRAM_OFFICER_NAME: AGYIN, JOSEPH KOFI

PROJECT_TERMS: activity-based protein profiling;analog;anti-cancer;Apoptosis;Autophagocytosis;BCL2 gene;BCL2L1 gene;Binding Sites;Biological Assay;Biological Process;cancer therapy;CASP2 gene;Caspase;Cell Death;Cells;Chimera organism;Chimeric Proteins;Clustered Regularly Interspaced Short Palindromic Repeats;Computer Models;Consumption;CRISPR/Cas technology;Cysteine;Data;design;Development;dietary;experimental study;Family;flexibility;Foundations;Future;Genes;Human;In Vitro;inhibitor;interest;Knock-out;Libraries;Ligands;Lysosomes;MCL1 gene;MDM2 gene;Mediating;Modality;multicatalytic endopeptidase complex;Names;Natural Products;novel strategies;Oncoproteins;Process;Property;Protac;protein degradation;protein function;Proteins;Proteolysis;recruit;screening;senolytics;Series;Site;Site-Directed Mutagenesis;small molecule;Solid;Structure;success;System;Tacrolimus Binding Proteins;Technology;Testing;Therapeutic;Time;tool;Ubiquitin;ubiquitin-protein ligase;weapons

PROJECT_TITLE: Development of Caspase Cleavage Targeting Chimeras (CACTACs) for Targeted Protein Cleavage

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 TCRB-V (O1)]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Complementary and Integrative Health;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Methamphetamine;Networking and Information Technology R&D (NITRD);Precision Medicine;Rehabilitation;Rural Health;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: CAMBRIDGE

ORG_NAME: CHARLES RIVER ANALYTICS, INC.

PHR: Project Narrative  The proposed research aims to design and develop a virtual reality (VR)–based cognitive behavioral therapy (CBT) system for treating stimulant use disorder (StUD). StUD, which includes the misuse of drugs like methamphetamine, cocaine, and other amphetamines, is associated with serious health consequences and is the leading cause of overdose death in many western US states. Currently, there is no pharmacological treatment available for StUD and psychosocial interventions, such as CBT, are considered the standard treatment. However, traditional CBT has high relapse rates and treatment dropout, suggesting that more robust approaches are needed. The proposed VR-CBT system has the potential to improve treatment outcomes and reduce relapse rates by providing patients with a safe and immersive environment to practice coping strategies and build communication skills.

PI_NAMEs: BRACKEN, BETHANY K (contact)

PROGRAM_OFFICER_NAME: ANGELONE, LEONARDO MARIA

PROJECT_TERMS: 3-Dimensional;addiction;Address;Adherence;Amphetamines;Anxiety;associated symptom;Award;barrier to care;Cardiovascular system;Cessation of life;Chronic;Clinical;Cocaine;Cognitive Therapy;Communication;comorbidity;contingency management;Controlled Environment;Coping Skills;craving;Crime;design;Dialectical behavior therapy;digital;Disease;disease transmission;Dropout;drug misuse;Effectiveness;effectiveness validation;Elements;Emotional;Ensure;Environment;Environment Design;Evaluation;Feedback;Fentanyl;Goals;Government;Health;Health Services Accessibility;Home;Housing;Human;Improve Access;improved;Individual;individual patient;Intervention;Location;medical schools;Mental Depression;Methamphetamine;Methamphetamine misuse;Mindfulness Training;Modification;Morbidity - disease rate;mortality;Nature;Opioid;Outcome;Overdose;overdose death;Patient Self-Report;Patients;personalized approach;personalized medicine;Persons;Pharmaceutical Preparations;Pharmacological Treatment;Pilot Projects;preference;Privacy;problem solving therapy;programs;Protocols documentation;prototype;psychosocial;Recovery;recruit;reduced substance use;Relapse;Reporting;Research;research clinical testing;Risk;Risk Management;rural area;Safety;Schedule;Severities;skills;social stigma;standard care;Stimulant;stimulant dependence;stimulant use;stimulant use disorder;stressor;System;Technology;telehealth;Testing;Therapeutic;Therapeutic Uses;Time;timeline;tool;Treatment Effectiveness;Treatment outcome;underserved area;United States Food and Drug Administration;Universities;US State;usability;Use Effectiveness;virtual environment;virtual reality;virtual reality environment;Withdrawal Symptom;Work

PROJECT_TITLE: Stimulant Use Recovery Via Immersive Virtual Environments (SURVIVE)

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 SAI-S (A1)]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Behavioral and Social Science;Biodefense and Related Countermeasures;Dental, Oral, and Craniofacial Disease;Emerging Infectious Diseases;Infectious Diseases;Neurosciences;Prevention;Rare Diseases;Vector-Borne Diseases

PHR: PROJECT NARRATIVE  This proposal addresses a topic that is severely understudied, mosquito taste, in a species that is also understudied, Aedes albopictus, despite its being one of the most dangerous mosquito species. Here, we propose a multidisciplinary approach to investigate how Aedes albopictus senses tastants to guide biting behaviors. This study is designed to aid in the development of biologically and environmentally safe agents to control these mosquitoes and the diseases that they transmit including dengue, yellow fever, Zika, and Chikungunya.

PI_NAMEs: BAIK, LISA SOYEON (contact)

PROGRAM_OFFICER_NAME: RIVERA-RENTAS, ALBERTO L

PROJECT_TERMS: Address;Aedes;Affect;Antarctica;Asian;Attention;base;Behavior;Behavioral;behavioral response;Bite;Blood;career development;Chemicals;chikungunya;climate change;Code;CRISPR/Cas technology;Cues;Culicidae;Dangerousness;Dengue;design;Detection;Development;Disease;disease transmission;Disease Vectors;Electrophysiology (science);Environment;Funding;Genetic;Health;Human;Human Bites;human old age (65+);improved;Individual;interdisciplinary approach;interest;Invaded;Investigation;Machine Learning;Mentors;Methods;Molecular;Molecular Genetics;Mosquito Control;mutant;Neurons;novel;Persons;Phase;Physiological;Physiology;Planet Earth;Positioning Attribute;prevent;Prevention;professor;receptor;research and development;Research Personnel;response;Role;Secure;sensory system;Skin;Surface;System;Taste Buds;Taste Perception;taste stimuli;taste system;Techniques;Testing;Tigers;tool;Training;transcriptome sequencing;Transgenic Organisms;Universities;vector control;vector mosquito;vector-borne pathogen;virtual;Visual;Yellow Fever;ZIKA

PROJECT_TITLE: Taste perception of host cues in the invasive disease vector mosquito Aedes albopictus

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: LOS ANGELES

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

ORG_STATE: CA

PHR: Project Narrative Viral and bacterial infections result in transient neuroinflammation and are a common occurrence throughout life, yet how or why temporary inflammation increases the risk of developing neurodegenerative disease (ND) remains elusive. Similarly, despite the key role of astrocytes in neuron function and modulating the immune response, they are often overlooked in the study of ND. The proposed research will address these outstanding questions and provide fundamental insight into how transient astrocyte reactivity affects future insults and how this impacts on ND.

PI_NAMEs: MCCALLUM, SARAH  (contact)

PROGRAM_OFFICER_NAME: OPANASHUK, LISA A

PROJECT_TERMS: Acute;acute infection;Affect;age related neurodegeneration;Aging;aging population;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Antigen Presentation;Astrocytes;ATAC-seq;Attenuated;Bacterial Infections;Behavioral;Biological Response Modifiers;Brain;Cardiovascular Diseases;cell type;Cells;Cellular biology;Central Nervous System;ChIP-seq;Chromatin;Chronic;combat;Cues;Data;Dependovirus;Disease;Disease Progression;Ensure;Epigenetic Process;epigenetic silencing;epigenomics;Etiology;Exhibits;Future;gain of function;Gene Activation;Gene Expression;Gene Mutation;Genes;Genetic Transcription;Goals;human old age (65+);Immune;Immune response;Immune Tolerance;Immunity;Immunologic Memory;immunoregulation;Infection;Inflammation;Inflammatory;Inflammatory Response;Injury;Innate Immune Response;insight;knock-down;Life;Lipopolysaccharides;Maintenance;Malignant Neoplasms;Mediating;Mediator;Medicine;Memory;memory encoding;Methodology;Molecular;Morphology;mouse model;Mus;Myelogenous;Natural regeneration;Nerve Degeneration;nervous system development;neural;Neurodegenerative Disorders;neuroinflammation;Neurons;normal aging;novel;novel therapeutics;Onset of illness;Pathogenesis;Pathologic;Pathology;Peripheral;Phagocytosis;Postdoctoral Fellow;Predisposition;Process;Regulation;Research;Resolution;response;Risk;Risk Factors;Role;Signal Transduction;Stat3 protein;Stimulus;Supporting Cell;Testing;Time;Tissues;Training;transcriptome sequencing;transcriptomics;Translations;Virus Diseases;Work

PROJECT_TITLE: Establishing reactive astrocyte memory as a risk factor for aging-related neurodegenerative disease

STUDY_SECTION_NAME: Career Development Facilitating The Transition to Independence Study Section[AGCD-1]


NIH_SPENDING_CATS: Genetics;Infectious Diseases;Sexually Transmitted Infections

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: The proposed studies are directed at understanding how the replication of human papillomaviruses (HPV) is regulated by DNA repair pathways. Our previous studies show that activation of the homologous recombination repair pathway, ATM and ATR, are required for viral replication. Our recent work show that two members from the related non-homologous repair pathways are also activated in HPV positive cells and at least one of these regulates viral replication. This proposal seeks to understand how these two additional pathways contribute to replication of HPV genomes.

PI_NAMEs: LAIMINS, LAIMONIS A. (contact)

PROGRAM_OFFICER_NAME: LINDE, AMBER SHRYER

PROJECT_TERMS: Address;Affect;arm;Ataxia Telangiectasia;ATR gene;Biological Assay;CASP3 gene;Cell Cycle Progression;Cell Cycle Regulation;cell growth;Cell Line;cell motility;Cells;chromatin immunoprecipitation;Complex;Critical Pathways;Dependence;Distal;DNA biosynthesis;DNA Repair;DNA Repair Pathway;DNA Sequence Alteration;DNA-PKcs;education pathway;Episome;Excision;Exhibits;G2 Phase;G22P1 gene;Genome;homologous recombination;HPV positive;Human Papillomavirus;Immunofluorescence Immunologic;Individual;inhibitor;insight;keratinocyte;knock-down;Lentivirus;Lesion;Life Cycle Stages;Ligase;Ligation;Link;Location;Measures;Mediating;member;Nonhomologous DNA End Joining;Nuclear;Oropharyngeal;Pathway interactions;Peptide Hydrolases;Pharmaceutical Preparations;Polymerase;Process;Productivity;promoter;Proteins;recombinational repair;recruit;Regulation;repaired;Reporter;Reporting;Repression;small hairpin RNA;Stratified Epithelium;Stratified Squamous Epithelium;Stratum Basale;System;Undifferentiated;Viral;viral DNA;Viral Genome;Viral Proteins;Virus Replication;Work;XRCC1 gene;XRCC4 gene;XRCC5 gene

PROJECT_TITLE: HPV replication and its dependence on repair pathways

STUDY_SECTION: MCV

STUDY_SECTION_NAME: Molecular and Cellular Biology of Virus Infection Study Section[MCV]


ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: Project Narrative (relevance of this research to public health): Our laboratory is studying recently discovered molecules that contribute to thrombosis—the formation of life- threatening, unwanted blood clots inside arteries or veins. These basic science studies have the potential to lead to new insights into how unwanted blood clots occur in heart attack, stroke and deep vein thrombosis. These studies may allow us to develop new treatments for diseases like thrombosis and fibrosis that are caused or influenced by improper functioning of the blood clotting system.

PI_NAMEs: MORRISSEY, JAMES H. (contact)

PROGRAM_OFFICER_NAME: WARREN, RONALD Q

PROJECT_TERMS: Area;Arteries;Basic Science;Blood;Blood coagulation;Blood Coagulation Disorders;Coagulation Process;Collagen;Complex;Deep Vein Thrombosis;Disease;Factor VIIa;Fibrosis;Goals;Grant;Hemostatic Agents;Hemostatic function;Human;immunothrombosis;Inflammation;Inflammatory;insight;Investigation;Laboratories;Life;Molecular;Myocardial Infarction;Nucleic Acids;pathogen;Pattern;Phospholipids;Polymers;Polyphosphates;Public Health;Reaction;Research;Stroke;success;System;therapeutic target;Thromboplastin;Thrombosis;vascular injury;Veins;Vision;Work

PROJECT_TITLE: Mechanisms in Blood Clotting

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-I (O1)]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Eye Disease and Disorders of Vision;Genetics;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: BALTIMORE

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative  Retinitis pigmentosa (RP) encompasses a large and heterogenous group of inherited eye diseases characterized by irreversible vision loss and blindness due to the death of the light-sensing photoreceptor cells of the retina. Despite affecting over 1.5 million individuals worldwide, treatment options for RP remain limited. This proposal uses three-dimensional stem cell-derived retinal organoids to model human retinal development and investigate why retinal cells are primarily, and often exclusively, susceptible to certain genetic mutations, particularly in genes that are universally expressed in cells throughout the body.

PI_NAMEs: KEUTHAN, CASEY  (contact)

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: 3-Dimensional;Affect;Alternative Splicing;Applied Skills;Award;bioinformatics pipeline;Blindness;Brain;career;Cell Line;cell type;Cells;Cessation of life;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;Cone;CRISPR interference;CRISPR-mediated transcriptional activation;CRISPR/Cas technology;Data;Data Set;Defect;design;Development;Disease;DNA Sequence Alteration;Engineering;Eukaryotic Cell;Event;experience;experimental study;Eye;Eye diseases;Frequencies;Functional disorder;Funding;Future;Gene Expression;Genes;Goals;Grant;Health;Human;human model;human stem cell-derived;human stem cells;in vivo;Individual;Inherited;insight;Knowledge;Learning;Length;Light;Mentors;Messenger RNA;Methods;Modeling;mRNA Precursor;multidisciplinary;mutant;Mutate;Mutation;nanopore;Nervous System;neuron development;Neurons;new therapeutic target;next generation;novel;Organoids;Pathway interactions;Patients;Pattern;Persons;Phase;Photoreceptors;Physiological;Play;Population;Predisposition;Process;Productivity;Protein Isoforms;Regulation;Research;Retina;Retinal Cone;Retinal Degeneration;Retinal Diseases;Retinal Ganglion Cells;retinal neuron;retinal rods;Retinitis Pigmentosa;RNA Helicase;RNA Splicing;Role;Specificity;Spliceosomes;stem cell organoids;stem cells;Technology;Therapeutic;Time;Tissues;Training;Transcript;transcriptome;transcriptome sequencing;transcriptomics;Variant;Vertebrate Photoreceptors;Work

PROJECT_TITLE: Investigating the Alternative Splicing Landscape of Human Retinal Development and Degeneration

STUDY_SECTION_NAME: Special Emphasis Panel[ZEY1 VSN (03)]


NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Orphan Drug;Pediatric;Pediatric Cardiomyopathy;Rare Diseases

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PROJECT NARRATIVE Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiac disorder. Cardiac fibrosis is a key feature of HCM, is associated with adverse outcomes, but there is no medical therapy that prevents fibrosis. HCM is a state of deficiency of C-type natriuretic peptide (CNP) and augmenting CNP signaling is a novel approach to target fibrosis in HCM.

PI_NAMEs: ARMSTRONG, DAVID WILLIAM JOHN (contact)

PROGRAM_OFFICER_NAME: WANG, WAYNE C

PROJECT_TERMS: Address;adverse outcome;Animal Genetics;Animal Model;Animals;antifibrotic treatment;Arrhythmia;atrial natriuretic factor receptor B;Attenuated;Award;Biological;Biological Assay;Biology;C-Type Natriuretic Peptide;Cardiac;cardiac magnetic resonance imaging;Cardiopulmonary;career;career development;Chronic;Clinical;Clinical Trials;clinically relevant;coronary fibrosis;Cyclic GMP;Data;Development;Development Plans;disability;DNA Sequence Alteration;effective therapy;Environment;Enzymes;Etiology;Evaluation;experimental study;Family;Fibroblasts;Fibrosis;Foundations;Funding;Future;Genetic Diseases;Goals;Health;Heart Diseases;Heart failure;Histologic;Human;Hypertrophic Cardiomyopathy;Hypertrophy;improved;In Vitro;in vitro Assay;in vivo;Inherited;innovation;Knowledge;Laboratory Research;Lead;Learning;Life;Magnetic Resonance Imaging;Medical;member;Mentors;Mission;Modeling;Molecular;mouse model;Mus;Myocardial;Natriuretic Peptides;Natural History;Neprilysin;new therapeutic target;novel;novel strategies;novel therapeutic intervention;Outcome;Pathway interactions;Patients;peptide analog;Peptide Signal Sequences;pharmacologic;Phase;Physicians;Positioning Attribute;Pre-Clinical Model;prevent;programs;Proliferating;Property;Research;Resistance;Risk Factors;Role;Scientist;Secure;skills;Sudden Death;targeted treatment;Testing;Therapeutic;tool;Training;United States National Institutes of Health;Wild Type Mouse

PROJECT_TITLE: C-type natriuretic peptide in hypertrophic cardiomyopathy

STUDY_SECTION: MTI

STUDY_SECTION_NAME: NHLBI Mentored Transition to Independence Study Section[MTI (OA)]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

ORG_CITY: ATLANTA

ORG_NAME: GEORGIA STATE UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE The US Food and Drug Administration (FDA) is moving forward with its groundbreaking plan to reduce tobacco-related death and disease by lowering nicotine in combusted cigarettes to minimally addictive levels. To maximize the benefits of this potentially life-saving policy, we developed messages about reduced nicotine and the health risks of using different tobacco products. We will test the effects of these messages on behavioral outcomes in priority populations in the context of using very low nicotine content cigarettes, approximating the initial implementation of a national nicotine reduction policy accompanied by a communication campaign.

PI_NAMEs: POPOVA, LYUDMILA  (contact)

PROGRAM_OFFICER_NAME: BLAKE, KELLY D

PROJECT_TERMS: Address;Behavior;behavioral outcome;Blinded;Categories;Cessation of life;Cigarette;cigarette smoke;cigarillos;clinical trial participant;Cognitive;cognitive function;combustible cigarette;Communication;Communication Research;Data Collection;Disease;Disparate;Economically Deprived Population;Education;Effectiveness;Electronic cigarette;Emotional;experience;experimental study;Exposure to;Focus Groups;former smoker;Funding;General Population;Health;health disparity;high school;Life;low nicotine content cigarette;low socioeconomic status;Mental Health;Misinformation;Motivation;Nicotine;Outcome;Participant;Persons;Physiological;Policies;Population;preventable death;primary outcome;Printing;Proliferating;psychological distress;public education;Qualitative Research;Randomized;randomized, clinical trials;Reaction;Research;Research Personnel;Risk;Savings;Science;secondary outcome;Smoke;Smoker;Smoking;Smoking Behavior;smoking cessation;social disparities;socioeconomic disadvantage;Socioeconomic Status;Special Population;Stream;success;Testing;Tobacco;Tobacco Industry;tobacco products;Tobacco use;United States Food and Drug Administration;Visit

PROJECT_TITLE: Communicating about Nicotine and Differential Risks of Tobacco Products in Priority Populations

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CCHI-X (56)]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Human Genome

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: Project Narrative Heart failure from ischemic heart disease is the leading cause of morbidity, mortality, and healthcare expenditure worldwide. The long-term goal and the clinical significance of this K08 grant is to provide the basis for the development of a novel therapeutic factor for the treatment of ischemic heart disease that promotes adult fibroblast to cardiomyocyte reprogramming following myocardial infarction. The results from these studies will deepen our understanding of mechanisms that drive reprogramming and serve as an important pre-clinical platform for the advancement of cardiac reprogramming therapies in patients suffering from heart failure and ischemic heart disease.

PI_NAMEs: BANN, GLYNNIS GARRY (contact)

PROGRAM_OFFICER_NAME: NEILSON, KAREN MARY

PROJECT_TERMS: Acute;Address;Adult;Advisory Committees;ATAC-seq;Award;Binding;Binding Sites;Biological Assay;Biology;Calcium;Cardiac;Cardiac Myocytes;cardiac regeneration;Cardiovascular system;career;career development;Cell Reprogramming;Cells;ChIP-seq;Chromatin;Chromium;Chronic;clinical application;clinical translation;clinically significant;cofactor;Data;Development;efficacy evaluation;Enhancers;Ensure;Epigenetic Process;epigenome;epigenomics;Event;Fellowship;Fibroblasts;Flow Cytometry;GATA4 gene;Gene Expression Profiling;Genes;Genetic;Genetic Transcription;genome-wide;Goals;Grant;Health Expenditures;Heart;Heart Diseases;Heart failure;heart function;Histologic;Histones;Human;immunocytochemistry;improved;in vivo;Injections;Injury;Institution;Internal Medicine;Laboratories;Mediating;Medical;Mentors;Mentorship;Modality;Modification;Molecular Biology;Morbidity - disease rate;mortality;multiple omics;Mus;Muscle;Muscle Cells;Myocardial Infarction;Myocardial Ischemia;Myocardium;Natural regeneration;novel therapeutics;overexpression;Patients;physician-scientist training program;Physicians;Positioning Attribute;Postdoctoral Fellow;pre-clinical;Productivity;programs;Reader;Research;Research Personnel;Residencies;Resources;response to injury;Role;Scientist;success;Supporting Cell;SWI/SNF Family Complex;Technology;Testing;Training;transcription factor;transcriptome;transcriptome sequencing;Treatment Factor;Universities;Work;XCL1 gene

PROJECT_TITLE: Characterization of PHF7 function in mediating cardiac reprogramming

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS (OA)]