NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Cardiovascular;Heart Disease;Hematology;Lung;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Physical Injury - Accidents and Adverse Effects;Pregnancy;Pulmonary Hypertension

ORG_CITY: Aurora

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: R01 ES035431_Administrative Supplement PI: Veress PROJECT NARRATIVE Inhalation of toxic chemicals often causes lung and heart abnormalities that develop and worsen over time after initial exposure in adult patients, while impacts of these exposures on children is not well characterized. In this project, we will study the long-term effects of in utero mustard gas and chlorine gas exposures on offspring born to inhalation exposed mother rats. The findings of this application will improve our understanding of heart and lung problems in a developing pediatric rat after in utero chemical exposure.

PI_NAMEs: VERESS, LIVIA AGNES (contact)

PROGRAM_OFFICER_NAME: NADADUR, SRIKANTH

PROJECT_TERMS: Acute;Administrative Supplement;Adolescence;Adult;Age;airway obstruction;Alveolar;Angiopoietin-2;Animal Model;Animals;Aorta;Award;Biochemical;Biological Assay;Birth;Blood coagulation;Blood gas;Blood Vessels;Body Weight Changes;Calcium;Cardiac;cardiogenesis;Cardiopulmonary;Cardiovascular Diseases;Cardiovascular system;Chemical Exposure;Chemicals;Child;Childhood;Chlorine;chlorine gas;Chronic;Chronic lung disease;Coagulation Process;Data;Defect;Development;Dextrans;Dose;Echocardiography;Edema;Endothelial Cells;Endothelin-1;Endothelium;Event;Exposure to;Failure;Female;Fibrin;First Pregnancy Trimester;Functional disorder;Gases;Gene Expression Profile;Growth;Heart;Heart Abnormalities;Heart Rate;hemodynamics;Histology;Histopathology;Human;Hypertension;Hypertrophy;improved;in utero;in vivo;Infant;Inhalation;Inhalation Exposure;inhibitor;Injury;Lethal Dose 50;Long-Term Effects;Longitudinal Studies;Lung;lung development;Measurement;Modeling;Molecular;Morbidity - disease rate;Mothers;Muscle Cells;Mustard Gas;Myocardial dysfunction;National Institute of Environmental Health Sciences;neonate;Nervous System;Occupational Accidents;offspring;Organ;Outcome;Oxygen;Pathway interactions;Patients;pediatric patients;Permeability;Poison;Population;postnatal;Pregnancy;pregnant;prenatal exposure;protein expression;Proteomics;Pulmonary Hypertension;Pulse Oximetry;pup;rate of change;Rattus;Recovery;Reporting;Respiratory Failure;Rodent;Second Pregnancy Trimester;Signal Transduction;Sprague-Dawley Rats;Structure;Survivors;Tenascin;Third Pregnancy Trimester;Thrombosis;Time;time use;transcriptome sequencing;United States National Institutes of Health;Vascular Diseases;Vascular Endothelial Growth Factors;Vascularization;Ventricular Dysfunction;War;Weight;Western Blotting

PROJECT_TITLE: Development of pregnant animal model to evaluate sulfur mustard exposure in pediatric population


ADMINISTERING_IC: NS

ARRA_FUNDED: N

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Dementia;HIV/AIDS;Infectious Diseases;Neurodegenerative;Neurosciences

ORG_CITY: WASHINGTON

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: GEORGETOWN UNIVERSITY

ORG_STATE: DC

PHR: Lay Abstract A collection of cognitive abnormalities is seen in people living with HIV, despite antiretroviral therapy. Yet, the underlying causes of such impairments are not completely understood. This proposal intends to test the novel hypothesis that HIV causes cognitive impairments by promoting the accumulation of amyloid beta through the envelope protein gp120. The main mechanisms that we will examine is the ability of gp120 to target the neurotrophin receptor p75, which has been shown to mediate amyloid beta accumulation.

PI_NAMEs: MOCCHETTI, ITALO  (contact)

PROGRAM_OFFICER_NAME: DALEY, WILLIAM PATRICK

PROJECT_TERMS: abeta accumulation;Address;Adjuvant;Affect;Alleles;Amyloid beta-Protein;Amyloid beta-Protein Precursor;Anti-Retroviral Agents;antiretroviral therapy;Applications Grants;Area;Attention;Automobile Driving;Autopsy;Axon;behavioral impairment;Biological Markers;Brain;Brain Diseases;Brain-Derived Neurotrophic Factor;brain-derived neurotrophic factor precursor;Central Nervous System;Cerebrospinal Fluid;Cerebrum;Clinical;Clinical Research;Cognition;Cognitive;Collection;comorbidity;Complex;Data;Dendritic Spines;Disease;Endoplasmic Reticulum;endoplasmic reticulum stress;env Gene Products;Excision;Exhibits;experimental study;Functional disorder;Generations;Golgi Apparatus;Grant;gray matter;HIV;HIV Envelope Protein gp120;HIV Infections;HIV Seronegativity;HIV Seropositivity;HIV-1;HIV-associated neurocognitive disorder;Human;Impaired cognition;Impairment;In Vitro;Individual;Inflammation;Investigation;Knowledge;Ligands;Mediating;Messenger RNA;Microtubule-Associated Protein 2;Molecular;motor impairment;Mus;Nerve Degeneration;Neurocognitive Deficit;Neurodegenerative Disorders;neuroinflammation;Neurologic;Neurologic Dysfunctions;neuron loss;Neurons;neuroprotection;Neuropsychology;neurotoxic;neurotoxicity;NGFR Protein;novel;Pathologic;Pathology;Persons;Pharmacotherapy;Population;postsynaptic;presynaptic;Prevalence;Process;Protein Biosynthesis;Proteins;receptor;Reporting;Research Priority;Resistance;Risk Factors;Role;Sampling;Severities;Subgroup;symptomatology;Symptoms;Synapses;Testing;Toxic Actions;Transgenic Mice;United States;Up-Regulation;Viral Load result;Viral Proteins;white matter

PROJECT_TITLE: Role of proBNDF and p75NTR in HIV-mediated Axonal/Dendritic Degeneration

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


ADMINISTERING_IC: GM

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Childhood Injury;Mental Health;Mental Illness;Neurosciences;Pediatric;Prevention;Sleep Research;Suicide;Suicide Prevention

ORG_CITY: Riverside

ORG_NAME: EMMA PENDLETON BRADLEY HOSPITAL

ORG_STATE: RI

PI_NAMEs: KUDINOVA, ANASTACIA Y. (contact)

PROGRAM_OFFICER_NAME: GARTRELL, KYUNGSOOK

PROJECT_TERMS: 17 year old;Address;adolescent mental health;Affect;age group;Ambulatory Care;Behavioral Mechanisms;Biological Clocks;brain behavior;Cause of Death;Centers of Research Excellence;Child;circadian;Circadian Rhythms;Communities;critical developmental period;Day Care;Drowsiness;Ecological momentary assessment;experience;Feeling;Feeling suicidal;Functional Magnetic Resonance Imaging;innovation;Inpatients;Intervention;Life;Link;Measures;Methodology;neural;neural correlate;novel;Process;Public Health;recruit;reducing suicide;Research;Role;rumination;Sleep;sleep behavior;suicidal behavior;suicidal risk;Suicide;suicide rate;Techniques;Teenagers;Thinking;time interval;Youth

PROJECT_TITLE: Sleep and circadian timing and suicidal thoughts and behavior in youth: The role of self-referential processing and its neural correlates


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Nutrition;Obesity

ORG_CITY: CHAPEL HILL

ORG_DEPT: NUTRITION

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative – Overall Component The Nutrition Obesity Research Center (NORC) at the University of North Carolina at Chapel Hill (UNC) takes as its central theme “Interdisciplinary Nutrition Research: From Molecules to Public Health.” We propose an Administrative Core and four biomedical research cores: the Animal Metabolism Phenotyping Core, the Clinical and Community Human Assessment and Interventions Core, the Metabolism and Metabolomics Core, and the Precision Nutrition Core. As an integrated whole, the UNC NORC will provide the framework, tools, and expertise investigators need to engage in the interdisciplinary research required to improve health outcomes.

PI_NAMEs: MAYER-DAVIS, ELIZABETH J (contact);SHAIKH, SAAME R

PROGRAM_OFFICER_NAME: EVANS, MARY

PROJECT_TERMS: analytical tool;Animals;Assessment tool;Award;base;Basic Science;Behavior;behavior change;Behavior Therapy;Biochemical;Biological Markers;Biomedical Research;career;Clinical;Clinical Research;Clinical Sciences;Collaborations;Communication;Communities;community based research;Complex;cost effective;Data Analyses;Diet;digital intervention;Discipline;Doctor of Philosophy;Education;Effectiveness;Epidemiology;epidemiology study;Equipment;Fostering;Funding;General Population;genetic makeup;Grant;Health;Health Professional;Human;improved;Individual;Infrastructure;innovation;interdisciplinary approach;interdisciplinary collaboration;Interdisciplinary Study;Intervention;Intervention Studies;Investments;Laboratory Finding;Language;Leadership;member;Mentors;Metabolic;Metabolic Diseases;Metabolic Pathway;metabolic phenotype;Metabolism;metabolomics;Methodology;Methods;microbiome analysis;Mission;Molecular;mouse model;National Institute of Diabetes and Digestive and Kidney Diseases;North Carolina;novel strategies;nutrition;nutrition related genetics;Nutritional Study;Obesity;Outcome;Peer Review;Phenotype;Physicians;Policy Maker;Population;population based;precision nutrition;Problem Solving;programs;Public Health;public health research;Publications;Research;Research Methodology;Research Personnel;Resources;Risk;role model;Scientist;Services;Social Sciences;success;synergism;Techniques;tool;Training;Translating;Translation Process;Translational Research;United States National Institutes of Health;Universities;Variant;Work


ED_INST_TYPE: SCHOOLS OF MEDICINE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Brain Disorders;Genetics;HIV/AIDS;Infectious Diseases;Neurodegenerative;Neurosciences

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: GEORGE WASHINGTON UNIVERSITY

PHR: Narrative Chronic inflammation underlies pathogenesis of HIV-associated neuropathology, but it remains unclear why it persists when HIV replication is suppressed by anti-retroviral treatment. Our studies suggest that HIV can induce a pro-inflammatory epigenetic memory in peripheral myeloid cells. In the proposed study, we will test whether this memory extends to brain cells and can explain neuroinflammation.

PI_NAMEs: BUKRINSKY, MICHAEL ILYA (contact);SVIRIDOV, DMITRI

PROJECT_TERMS: Address;Affect;antiretroviral therapy;Astrocytes;ATAC-seq;Bioinformatics;blood-brain barrier penetration;Brain;brain cell;Cell Nucleus;cell type;Cells;Cholesterol Homeostasis;Chromatin;Chronic;Collaborations;comorbidity;Data Set;Development;Drug usage;Elements;epigenetic memory;Epigenetic Process;Exploratory/Developmental Grant;Exposure to;extracellular vesicles;Foundations;Future;Genes;Genetic Transcription;Goals;high reward;high risk;HIV;HIV Infections;HIV-1;HIV-associated neurocognitive disorder;humanized mouse;Immunity;Immunology;In Vitro;Individual;Inflammation;Inflammatory;Inflammatory Response;Innate Immune Response;innovation;Investigation;Memory;Metabolic;Methodology;Microglia;Modeling;Modification;Molecular;monocyte;mouse model;Myeloid Cells;nef Protein;Neurobiology;Neuroglia;neuroinflammation;neuropathology;novel;Oligodendroglia;Outcome;pathogen;Pathogenesis;Pathogenicity;Pathway interactions;Peripheral;Phenotype;Quality of life;Research Personnel;response;RNA;Stimulus;Testing;Therapeutic;therapy development;Training;Viral Proteins;virology;Virulence Factors;Virus

PROJECT_TITLE: Epigenetic mechanisms of HAND pathogenesis


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Hematology;Kidney Disease

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: Project narrative It is imperative to train researchers in clinical, scientific and technological areas to advance the fields of Kidney, Urology and Hematology (KUH) towards bringing better understanding and management to KUH conditions and diseases. This program in North Carolina combines expertise and novel concepts in Training, Research, Innovation, and Outreach to form the NC KUH TRIO Program, bringing together six institutions across the state; 3 academic medical centers and 3 historically black universities that have strong science, technology, and engineering programs. TRIO will support pre- and post-doctoral trainees, providing them with innovative research tools and a professional development foundation to launch KUH research careers.

PI_NAMEs: ALMEIDA-PORADA, GRACA DUARTE;CROWLEY, STEVEN D;HOGAN, SUSAN LYNN (contact)

PROGRAM_OFFICER_NAME: MARIC-BILKAN, CHRISTINE

PROJECT_TERMS: Academic Medical Centers;Address;Agriculture;Area;career;Career Mobility;Clinical;Clinical and Translational Science Awards;cohort;Collaborations;Development;disability;Disadvantaged;Discipline;Disease;Education Projects;empowerment;Engineering;experience;Exposure to;Faculty;Fostering;Foundations;Funding;Future;Goals;Grant;Growth;Hematological Disease;Hematology;high school;Historically Black Colleges and Universities;Infrastructure;innovation;Institution;Interdisciplinary Study;Kidney;Leadership;Learning;member;Mentors;multidisciplinary;National Institute of Diabetes and Digestive and Kidney Diseases;North Carolina;novel;outreach;Patients;peer coaching;Positioning Attribute;Postdoctoral Fellow;pre-doctoral;Principal Investigator;Process;programs;Research;Research Personnel;Research Training;Resources;Running;Science;skills;technological innovation;Technology;TNFSF15 gene;tool;Training;Training Programs;undergraduate student;Underrepresented Minority;Universities;university student;Urology

PROJECT_TITLE: Pre-doctoral Diversity Supplement to TLDK139567


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Biotechnology;Complementary and Integrative Health;Natural Products

ORG_CITY: ATLANTA

ORG_DEPT: CHEMISTRY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative This project utilizes synthetic chemistry, microbiology, genetics, and proteomic methods to develop novel compounds to combat bacteria. This research will develop narrow-spectrum and antivirulence tool compounds as potential therapeutic agents that either inhibit growth or biofilm processes within pathogenic bacteria. The compounds are derived from natural product scaffolds isolated from regions rich in chemical diversity and bioactivity, which will undoubtedly shed light on the chemical underpinnings of these complex microbial communities.

PI_NAMEs: WUEST, WILLIAM M (contact)

PROGRAM_OFFICER_NAME: BOND, MICHELLE RUEFFER

PROJECT_TERMS: Affect;analog;Area;Bacteria;Biochemical;Biological;Biological Assay;chemical property;chemical synthesis;Chemical Warfare;Chemicals;combat;Complex;design;Development;Disease;Endowment;Environment;Evaluation;fungus;Genetic;Goals;Growth;Health;Human;improved;inhibitor;interest;Invaded;Lead;medical implant;Methods;Microbial Biofilms;microbial community;Microbiology;Molecular Genetics;natural product derivative;natural product inspired;Natural Products;Nature;novel;novel strategies;novel therapeutics;Organic Synthesis;pathogenic bacteria;physical property;Plants;polymicrobial biofilm;prevent;Process;Property;Proteins;Proteomics;Reporting;Research;Resistance development;scaffold;Source;Synthesis Chemistry;Techniques;Testing;Therapeutic;Therapeutic Agents;therapeutic target;tool;transcriptomics;Translations;Virulence

PROJECT_TITLE: Natural Product-Inspired Approaches Toward The Development Of Antivirulence And Species-Specific Inhibitors

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-P(55)R]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: PITTSBURGH

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE  In the proposed research we will examine the mechanisms by which memantine, one of the few drugs approved for treatment of Alzheimer's disease, protects nerve cells from damage. We will study how memantine works physiologically, use computer modeling and medicinal chemistry to design and synthesize new neuroprotective drugs, and use the new drugs to deepen understanding of neuroprotective strategies. The proposed research will examine a new approach for developing therapeutic drugs and will produce lead compounds for future development of improved medications to treat Alzheimer's disease.

PI_NAMEs: JOHNSON, JON W. (contact)

PROGRAM_OFFICER_NAME: RUNKO, ALEXANDER PETER

PROJECT_TERMS: Acetylcholinesterase;Acetylcholinesterase Inhibitors;Activities of Daily Living;Address;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease therapeutic;American;antagonist;Area;Binding;Binding Sites;Biological Assay;Brain;cell injury;Cerebrovascular Disorders;channel blockers;Chemical Models;cholinergic neuron;chronic pain;Clinical;clinical efficacy;Clinical Trials;cognitive function;Communication;Compensation;Comprehension;Computer Models;Dementia with Lewy Bodies;Dependence;desensitization;design;Development;Disease;Docking;Drug Addiction;Drug Design;drug development;drug modification;effective therapy;Effectiveness;Epilepsy;Excitatory Synapse;excitotoxicity;Exhibits;experimental study;Exposure to;FDA approved;Functional disorder;Future;Glutamate Receptor;Goals;improved;in silico;inhibitor;innovation;Ketamine;Lead;Learning;Link;Mediating;Memantine;Memory;Methods;Modeling;molecular dynamics;Molecular Mechanisms of Action;Mutagenesis;mutant;N-Methyl-D-Aspartate Receptors;N-Methylaspartate;Nerve Degeneration;nerve supply;Nervous System Disorder;Nervous System Physiology;Neurobehavioral Manifestations;Neurodegenerative Disorders;neuron loss;Neurons;neuroprotection;Neuroprotective Agents;NMDA receptor A1;novel strategies;novel therapeutic intervention;novel therapeutics;Parkinson's Dementia;Pathologic;Pathology;Patients;Permeability;Pharmaceutical Chemistry;Pharmaceutical Preparations;Physiological;predictive modeling;Preparation;Probability;Process;programs;Property;rational design;receptor;Recombinants;Research;Role;Safety;side effect;Signal Transduction;simulation;Site-Directed Mutagenesis;Slice;Stroke;Synaptic plasticity;Testing;Therapeutic;Therapeutic Agents;therapeutically effective;Time;tool;Toxic effect;Traumatic Brain Injury;United States National Institutes of Health;vascular cognitive impairment and dementia;Vascular Dementia;Work

PROJECT_TITLE: Ca2+-Dependent Block by Mematine and Selective Inhibition of Overactive NMDA Receptors

STUDY_SECTION: BPNS

STUDY_SECTION_NAME: Biophysics of Neural Systems Study Section[BPNS]


ADMINISTERING_IC: AI

FUNDING_MECHANISM: NON SBIR/STTR CONTRACTS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: BETHESDA

ORG_NAME: TECHNICAL RESOURCES INTERNATIONAL, INC.

ORG_STATE: MD

PI_NAMEs: ELLIS, JESSICA  (contact)

PROJECT_TERMS: Clinical Research;clinical research site;Clinical Trials;Data;Monitor;Operations Research;programs;Research Personnel;Resources;Safety;Services;Site;Training

PROJECT_TITLE: DMID Clinical Research Operations & Management Support (CROMS)


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Nutrition;Obesity;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: We have little or no knowledge on how impaired adipogenesis in obesity develops leading to adipose tissue dysfunction. This grant proposes studies to identify the novel role of Lipocalin 2 in senescence and adipogenesis of adipose stem and progenitor cells through extracellular vesicle-mediated intercellular communication mechanism in high fat diet-induced obesity. This project will provide new insights into the pathogenesis of obesity-related metabolic disorders and pave the way for the development of new therapeutic approaches.    Figure 1. The role of Lcn2 in senescence & adipogenesis in adipose tissue during chronic overnutrition

PI_NAMEs: CHEN, XIAOLI  (contact)

PROGRAM_OFFICER_NAME: BLONDEL, OLIVIER

PROJECT_TERMS: Address;Adipocytes;adipose derived stem cell;Adipose tissue;Affect;Aging;Anabolism;Binding Proteins;Bioenergetics;Blood Vessels;Brown Fat;Cell Separation;Cells;Chronic;combat;Defect;design;Development;diet-induced obesity;Exhibits;extracellular;extracellular vesicles;Female;Functional disorder;Grant;Health;High Fat Diet;Homeostasis;Human;Hyperplasia;Impairment;Inflammatory;insight;intercellular communication;Investigation;Knockout Mice;Knowledge;LCN2 gene;Link;lipid biosynthesis;Mediating;Metabolic;Metabolic Diseases;Metabolic stress;Metabolic syndrome;Mitochondria;Mus;neutrophil;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutic intervention;Obese Mice;Obesity;overexpression;Overnutrition;Pathogenesis;Phosphatidic Acid;Phospholipase;Phospholipid Metabolism;Play;Population;preservation;prevent;Process;Production;progenitor;Regulation;response;Role;senescence;single-cell RNA sequencing;stem;stem cells;Therapeutic

PROJECT_TITLE: Lipocalin 2 as a Regulator of Phospholipid Metabolism in Adipose Mitochondrial Bioenergetics

STUDY_SECTION: BMDM

STUDY_SECTION_NAME: Basic Mechanisms of Diabetes and Metabolism Study Section[BMDM]


ORG_CITY: WORCESTER

ORG_DEPT: BIOLOGY

ORG_NAME: WORCESTER POLYTECHNIC INSTITUTE

ORG_STATE: MA

PHR: PROJECT NARRATIVE The principal goal of this project is to dissect and study the machinery that modulates RNA tailing and its effects on RNA stability and translation. These mechanisms will be explored during C. elegans oogenesis and early embryogenesis, taking advantage of the window of transcriptional inactivity when post-transcriptional regulation of gene expression is critical. In the process, this project will also identify essential genes for oogenesis and shed light on how their regulation is critical to their physiological function in the oocyte.

PI_NAMEs: VIEUX, KARL-FREDERIC  (contact)

PROGRAM_OFFICER_NAME: VATAKIS, DIMITRIOS NIKOLAOS

PROJECT_TERMS: Age Years;Aneuploidy;Animal Model;Biological Models;Biology;Caenorhabditis elegans;Cell division;cofactor;Data;Deterioration;Development;Embryo;Embryonic Development;Enzymes;Epigenetic Process;Essential Genes;Excision;Exonuclease;Female;Fertility;Fertilization;Foundations;Functional disorder;Gametogenesis;Gene Expression;Gene Expression Regulation;Genetic Transcription;Genome;Genomics;Germ Cells;Germ Lines;Goals;Gonadal structure;Growth;Impairment;Incidence;Laboratories;Length;Maternal Age;Mediating;Mediator;Meiosis;Mentors;Messenger RNA;Metabolic;Methods;MicroRNAs;Mitotic;model organism;Modeling;Molecular;molecular marker;mutant;nanopore;novel;Nucleotides;older women;oocyte maturation;oocyte quality;Oocytes;Oogenesis;Organelles;Oxidative Stress;Pathology;Pathway interactions;Pattern;Phase;Physiological;Population;post-doctoral training;Post-Transcriptional Regulation;posttranscriptional;Process;Qualifying;Reagent;recruit;Regulation;Reproduction;reproductive;Research;RNA;RNA Processing;RNA Stability;RNA, Messenger, Stored;Role;Sexual Reproduction;spatiotemporal;Tail;Techniques;Training;Transcript;Transcription Process;transcriptome;transcriptomics;Transferase;Translational Regulation;Translations;Work;zygote

PROJECT_TITLE: Studying the modulators and the physiological functions of RNA tailing in the C. elegans oocyte

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Genetics;Hydrocephalus;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: NEW YORK

ORG_DEPT: PATHOLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: Program Director/Principal Investigator (Last, First, Middle): Teich, Andrew, Franklin Project Narrative Alzheimer’s disease (AD) is the number one cause of dementia in the western world, and is a major cause of mortality and morbidity. Brain inflammation involving cells called microglia has recently been recognized as an important component of AD, although how microglia contribute to dementia is not completely clear. This proposal will lead to a better understanding of the types of microglia that are active in brain tissue from patients with early AD pathology, and link this to biomarkers in cerebral spinal fluid that may be useful for predicting clinical outcomes. OMB No. 0925-0001/0002 (Rev. 03/16 Approved Through 10/31/2018) Page Continuation Format Page

PI_NAMEs: MCKHANN, GUY M;TEICH, ANDREW FRANKLIN (contact)

PROGRAM_OFFICER_NAME: OPANASHUK, LISA A

PROJECT_TERMS: Age;aging population;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease patient;Amyloid;Autopsy;Biological Markers;Biopsy;Blood;Brain;Brain Pathology;brain tissue;Categories;Cells;Cerebrospinal Fluid;Chronic;Clinical;clinical outcome measures;Cognitive;comorbidity;Data;Dementia;density;Deposition;Elderly;Encephalitis;Enzyme-Linked Immunosorbent Assay;Etiology;Frequencies;Future;Gene Cluster;Gene Expression;Genes;Genetic;Genetic Markers;genome wide association study;Goals;Grant;Histologic;Human;Hydrocephalus;Image;Immune response;Impaired cognition;Investigation;Link;Literature;Measures;Microglia;Morbidity - disease rate;Morphologic artifacts;mortality;Mus;Normal Pressure Hydrocephalus;older patient;Operative Surgical Procedures;Outcome;Pathology;Patients;Physiology;Population;potential biomarker;predict clinical outcome;predictive marker;predictive signature;Predictive Value;Principal Investigator;programs;Proteins;Proteomics;reduce symptoms;Reporting;response;Senile Plaques;Shunt Device;spatial relationship;Specimen;Symptoms;tau Proteins;tau-1;Testing;Time;Tissues;transcriptome sequencing;Ventricular;Visualization;Western World;Work

PROJECT_TITLE: An investigation of Alzheimer's Disease pathology, microglial immune response, and CSF proteomics in normal pressure hydrocephalus patients

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Regenerative Medicine

ORG_CITY: PHILADELPHIA

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

PHR: PROJECT NARRATIVE This proposal will investigate the therapeutic role of small Cajal body-specific RNAs in ischemic cardiac repair. Therefore, this proposal will be significantly relevant for progressing public health and enhancing the length and quality of life of millions of patients with cardiovascular diseases.

PI_NAMEs: GARIKIPATI, VENKATA NAGA SRIKANTH (contact)

PROGRAM_OFFICER_NAME: SHI, YANG

PROJECT_TERMS: Accounting;Acute;adeno-associated virus 9 delivery;Alternative Splicing;angiogenesis;Angiogenic Proteins;Apoptosis;Attenuated;Binding Sites;Biochemical;cadherin 5;Cardiac;Cardiac Myocytes;cardiac repair;cardiogenesis;cardioprotection;Cardiovascular Diseases;cardiovascular disorder therapy;Cardiovascular system;Cause of Death;Cell Death;Cell Physiology;Cell Proliferation;Cell Survival;Cells;Cessation of life;Data;Development;Diagnosis;effective therapy;Endothelial Cells;extracellular vesicles;gain of function;Guide RNA;Heart;Heart failure;heart function;Heart Injuries;Hypoxia;Impairment;improved;In Vitro;in vivo;induced pluripotent stem cell;induced pluripotent stem cell derived cardiomyocytes;Induction of Apoptosis;Infarction;injury and repair;innovation;Innovative Therapy;insight;Ischemia;knock-down;Knowledge;Left Ventricular Function;Length;Mass Spectrum Analysis;Mediating;Messenger RNA;Methylation;migration;Modeling;Modification;Molecular;Mus;mutant;Myocardial dysfunction;Myocardial Infarction;myocardial injury;Myocardial Ischemia;neovascularization;Nephroblastoma;new therapeutic target;novel;novel diagnostics;novel therapeutics;Nucleotides;Outcome;overexpression;paracrine;Patients;Pattern;Play;Post-Transcriptional Regulation;posttranscriptional;preservation;Process;Prognosis;promoter;Public Health;Quality of life;Regimen;repaired;reparative capacity;Reperfusion Injury;Ribose;RNA;Role;Small Nuclear RNA;Small Nucleolar RNA;Small RNA;Spliceosomes;Stress;Testing;Therapeutic;therapeutic angiogenesis;therapeutic RNA;tissue repair;tool;transcriptome sequencing;treatment strategy;Tube;U4 Small Nuclear Ribonucleoproteins;U4 small nuclear RNA;United States;Untranslated RNA;WT1 gene

PROJECT_TITLE: Role of small RNAs in ischemic tissue repair

STUDY_SECTION: MPPB

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology B Study Section[MPPB]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Assistive Technology;Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Data Science;Dementia;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Primary Health Care

ORG_CITY: Millbrae

ORG_NAME: CARE.COACH CORPORATION

ORG_STATE: CA

PHR: NARRATIVE This commercialization readiness pilot will deliver a scalable, state-of-the-art consumer-facing conversational agent and virtual health assistant that is overseen by humans and was developed with and for older adults, especially those aging with Alzheimer’s disease (AD) and related dementias (ADRD). This commercially-viable product has the potential to improve the health and wellbeing of millions of Americans within 5 years, including those aging with ADRD.

PI_NAMEs: KERSSENS, CHANTAL M (contact)

PROGRAM_OFFICER_NAME: HOROWITZ, TODD S

PROJECT_TERMS: accountable care organization;adjudication;Adopted;age related;Aging;Alzheimer's disease related dementia;American;Architecture;arm;Artificial Intelligence;Artificial Intelligence platform;automated speech recognition;Automation;Benchmarking;Brain Pathology;Businesses;California;care costs;Caring;chatbot;Clinical Decision Support Systems;clinical implementation;commercialization readiness;Communities;Community Health;Consumer Satisfaction;cost;data exchange;Data Reporting;Databases;design;Development;digital health;Drooling;Effectiveness;Elderly;Electronic Health Record;Ensure;Equity;Family Caregiver;Funding;Goals;Health;health care delivery;Health Insurance;Health Personnel;health plan;Healthcare;Home;Human;Human Resources;improved;industrial production;Industry;information organization;Infrastructure;innovation;Insurance Carriers;insurance claims;interest;Knowledge;knowledge integration;knowledge of results;large language model;Loneliness;manufacture;Marketing;Medical;meetings;Methods;Modeling;Neurologic;older adult;operation;Outcome;Patients;Performance;performance tests;Personal Satisfaction;Persons;Phase;Population;Preparation;Privacy;Process;Production;promoter;Provider;rapid growth;Recommendation;Reporting;research and development;Risk;Running;Security;social assistive robot;Speech;speech recognition;success;System;Technology;technology platform;Testing;Time;Training;usability;virtual health;Visit;web app;Work;Workload

PROJECT_TITLE: A State-of-the-Art Automatic Speech Recognition and Conversational Platform to Enable Socially Assistive Robots for Persons with Alzheimer's Disease and Related Dementias


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Digestive Diseases;Liver Cancer;Liver Disease;Orphan Drug;Rare Diseases

ORG_CITY: LEXINGTON

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PI_NAMEs: ALI, EUNUS  (contact)

PROJECT_TERMS: Applications Grants;Award;cancer cell;Cancer Center;Cancer Etiology;cancer type;Carbon;career;cell growth;Cells;chemotherapy;Data;Drug resistance;Enzymes;Growth;improved;innovation;Isotopes;Kentucky;KRAS2 gene;Light;Link;Malignant Epithelial Cell;Malignant neoplasm of liver;Malignant Neoplasms;MAP Kinase Gene;Messenger RNA;Metabolic Pathway;Metabolism;metabolomics;Modeling;Molecular;mortality;mutant;new therapeutic target;novel;overexpression;Pathway interactions;Patients;Primary carcinoma of the liver cells;Prognosis;Protein Overexpression;Proteins;Purine Nucleotides;Purines;Regulation;Research;Role;Therapeutic;TP53 gene;Transfer RNA;tumor;tumor growth;tumor metabolism;Tumor Promotion;United States;United States National Institutes of Health;Universities;Up-Regulation;Work

PROJECT_TITLE: Regulation of one-carbon metabolism and purine synthesis by YRDC in hepatocellular carcinoma


NIH_SPENDING_CATS: Biotechnology;Climate-Related Exposures and Conditions;Immunization;Prevention;Vaccine Related

ORG_CITY: OSWEGO

ORG_NAME: COLLEGE AT OSWEGO

PHR: Project Narrative: This project supports purchasing an ultralow freezer crucial for storing biological materials to achieve aims of developing thermostable viral vaccine formulations, improving vaccine distribution globally.

PI_NAMEs: MIRJAFARI, ARSALAN  (contact)

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TERMS: Biocompatible Materials;Cell Line;Funding;Grant;Hurricane;improved;National Institute of General Medical Sciences;Parents;Solvents;thermostability;vaccine distribution;vaccine formulation;Vaccines;Viral Vaccines;Virus

PROJECT_TITLE: Enhancing Vaccine Thermostability with Natural Deep Eutectic Solvents


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Infectious Diseases;Wound Healing and Care

ORG_NAME: COLUMBIA UNIV NEW YORK MORNINGSIDE

PHR: Contact PD/PI: CORNISH, VIRGINIA W Project Narrative The goal of this application is to develop broadly enabling synthetic biology tools and strategies for engineering yeast biosensors, yeast therapeutics, and yeast sense-respond communities. To meet this goal, we plan to develop yeast that can sense different bacterial infections in wounds, secrete different antibiotics in wounds, and finally can secrete specific antibiotics in response to the bacteria present in the wound. Project Narrative Page 7

PI_NAMEs: CORNISH, VIRGINIA W (contact)

PROGRAM_OFFICER_NAME: SIMONOVIC, MILJAN

PROJECT_TERMS: Antibiotics;arm;Bacteria;Bacterial Infections;Biosensor;Cells;cellular engineering;Communities;Disease;Engineering;Genetic;Goals;human disease;In Situ;Mammalian Cell;Methods;Pharmaceutical Preparations;Positioning Attribute;protein purification;Research;response;Saccharomyces cerevisiae;Site;small molecule;synthetic biology;Technology;Therapeutic;Therapeutic community technique;tool;Virginia;wound;wound healing;Yeasts

PROJECT_TITLE: Living Yeast Sense-Respond Therapeutic Communities Engineered with Synthetic Biology


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Neurodegenerative;Neurosciences;Rare Diseases

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: NARRATIVE Leukodystrophies are inherited diseases that affect the white matter of the brain due to the loss or absence of myelin, the lipid membrane that insulates axons in the nervous systems. In collaboration with advocacy partners, we have successfully formed a research-based consortium, the Global Leukodystrophy Initiative Clinical Trials Network (GLIA-CTN), representing industry partners, advocacy groups and research scientists. The GLIA-CTN is developing a clinical trial readiness infrastructure across the leukodystrophies, enabling transformation of the field.

PI_NAMEs: EICHLER, FLORIAN S;FATEMI, S. ALI ;VANDERVER, ADELINE LUCIE (contact)

PROGRAM_OFFICER_NAME: MORRIS, JILL A

PROJECT_TERMS: Administrative Supplement;Advocacy;Affect;Axon;Bioinformatics;Brain;clinical outcome assessment;clinical trial readiness;Clinical Trials Design;Clinical Trials Network;Collaborations;Communities;Computerized Medical Record;Data;data integration;data sharing;Disease;Epidemiologist;Hereditary Disease;industry partner;Infrastructure;Knowledge;leukodystrophy;Membrane Lipids;Methodology;Molecular;Myelin;Natural History;Nervous System;novel;Pathway interactions;Patient advocacy;Patient Outcomes Assessments;Pediatric Hospitals;Philadelphia;preclinical development;programs;Reproducibility;Research;Scientist;sharing platform;Time;Translating;white matter

PROJECT_TITLE: Global Leukodystrophy Initiative Clinical Trials Network Gap Year Administrative Supplement


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases

PROJECT_TERMS: Antibiotic Resistance;Antimicrobial Resistance;Clinical Research;clinical research site;Clinical Trials;Combating Antibiotic Resistant Bacteria;Data;Gram-Negative Bacteria;Monitor;Operations Research;programs;Research;Research Personnel;Resources;Safety;Services;Site;Training

PROJECT_TITLE: Clinical Research Operations and Management Support (CROMS) for Antimicrobial Resistant Research


PROJECT_TERMS: Clinical Research;clinical research site;Clinical Trials;Data;Monitor;Monkeypox;Operations Research;programs;Research Personnel;Resources;Safety;Services;Site;Training

PROJECT_TITLE: DMID Clinical Research Operations & Management Support (CROMS): mpox activities


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Coronaviruses;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Infectious Diseases;Vaccine Related

PROJECT_TERMS: 2019-nCoV;Clinical Research;clinical research site;Clinical Trials;Data;Monitor;Operations Research;programs;Research Personnel;Resources;Safety;Services;Site;Training

PROJECT_TITLE: DMID Clinical Research Operations & Management Support (CROMS), SARS-CoV-2


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cardiovascular;Clinical Research;Comparative Effectiveness Research;Cost Effectiveness Research;Dementia;Depression;Heart Disease;Infectious Diseases;Mental Health;Neurodegenerative;Neurosciences;Palliative Care;Prevention

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE Almost half of all people diagnosed with HIV in the United States are older than 50 years and are expected to live near normal life expectancies given effective antiretroviral therapy; however, people aging with HIV are at increased risk for dementia, as well as depression and cardiovascular disease. In this project, we will develop a multimorbidity simulation model for dementia, depression, cardiovascular disease, and HIV and will use the model to project chronic disease outcomes, quality of life, and costs associated with aging. The overall goal is to investigate the long-term clinical and economic consequences of different strategies to reduce dementia and multimorbidity among people aging with HIV.

PI_NAMEs: HYLE, EMILY PARKER (contact)

PROGRAM_OFFICER_NAME: SALIVE, MARCEL

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Advocate;Age;Age Years;aged;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;American;antiretroviral therapy;Area;Cardiovascular Diseases;cardiovascular disorder prevention;care costs;Caring;Chronic Disease;Clinical;clinical care;Clinical Trials;clinically relevant;cohort;Cohort Studies;Collaborations;comorbidity;cost;Cost Analysis;cost effective;cost effectiveness;Cost Effectiveness Analysis;cost of dementia;Cost of Illness;cost outcomes;Data;Dementia;dementia risk;depression model;design;Development;Diagnosis;Disease;disease model;Disease Outcome;economic outcome;Economics;effective therapy;Epidemiology;Etiology;Event;evidence base;experience;Functional disorder;Future;General Population;Goals;Guidelines;Health Care Costs;Heart;high risk;HIV;Impaired cognition;improved;Incidence;Individual;innovation;interest;International;Intervention;Life Expectancy;life time cost;Major Depressive Disorder;Mental Depression;Mental Health;Methods;Modeling;models and simulation;modifiable risk;Morbidity - disease rate;mortality;mortality risk;multidisciplinary;multiple chronic conditions;National Institute on Aging;Neurocognitive;novel;Outcome;Patients;Persons;Policies;Population;prevent;Prevention;Prevention strategy;Public Health;Quality of life;Recording of previous events;Research;Resources;Risk;Risk Factors;Strategic vision;Structure;synergism;Time;Treatment Effectiveness;United States;Update;Vulnerable Populations

PROJECT_TITLE: The CHARMED model: a multimorbidity simulation model for people aging with HIV

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


ADMINISTERING_IC: EB

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Clinical Research;Social Determinants of Health

ORG_CITY: WEST LAFAYETTE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: PROJECT NARRATIVE The development of innovative medical devices and technologies depends on a biomedical engineering workforce capable of identifying unmet clinical needs and working in teams to develop design solutions. Clinics in urban environments present unique health care issues, and this clinical immersion and team-based design program will challenge students to engage in engineering design in this context, with socioeconomic considerations in mind. The project will implement the novel INdiana Summer Clinical Residency in Innovation for Biomedical Engineers [(IN)SCRIBE] Program at Indiana University–Purdue University Indianapolis, in collaboration with the IU School of Medicine, to prepare biomedical engineering students for clinically-relevant, team-based design in an urban setting.

PI_NAMEs: MILLER, SHARON JANELL (contact)

PROGRAM_OFFICER_NAME: GUTEKUNST, DAVID JOSEPH

PROJECT_TERMS: Academia;Achievement;Address;Affect;Area;Articulation;Awareness;Biomedical Engineering;Chronic Disease;Cities;Clinic;Clinical;clinically relevant;Collaborations;Communication;Complex;Death Rate;Decision Making;design;Development;Documentation;Education;Educational Curriculum;Engineering;engineering design;Environment;ethnic diversity;experience;Faculty;Health;health care delivery;health care disparity;Health Professional;Health Sciences;Healthcare;Human Resources;Immersion;improved;Indiana;Industry;Infant Mortality;innovation;Instruction;Knowledge;Legal patent;Literature;Medical;Medical Device;medical schools;Medical Technology;Medicine;Mentors;Mind;Mission;Modeling;multidisciplinary;novel;Nurses;Obesity;Organism;Patients;people of color;Persons;Physicians;Plague;Population;Positioning Attribute;Poverty;programs;racial diversity;real world application;Research;Research Personnel;Residencies;Resources;Rotation;Schools;Self Efficacy;skills;Smoking;social;social consciousness;Societies;socioeconomic disparity;Socioeconomic Factors;socioeconomics;student participation;Students;Technology;Training;Translating;Translations;undergraduate student;United States National Institutes of Health;Universities;Urban Health;urban setting

PROJECT_TITLE: A Clinical Immersion Program to Train Biomedical Engineers to Identify Indiana's Urban Health Needs


ORG_CITY: DETROIT

ORG_DEPT: PHARMACOLOGY

ORG_NAME: WAYNE STATE UNIVERSITY

ORG_STATE: MI

PHR: Narrative Although a strikingly similar spectrum of disease symptoms, including blindness and neurodegeneration, are associated with the misregulation of protein complexes critical for controlling gene expression and cytoskeletal organization, the mechanisms linking the regulation of these complexes are not well understood. Here, we leverage a newly identified regulatory axis between the gene regulatory complex “SAGA” and the cytoskeletal regulatory complex “WRC” to understand the molecular components involved in this regulatory pathway, the basic mechanisms of their co-regulation, and the major biological functions that depend on their interplay. These experiments will provide new insight into the underlying mechanisms contributing to blindness and neurodegeneration and inform the search for new therapeutics to treat these devastating diseases.

PI_NAMEs: MOHAN, RYAN DAVID (contact)

PROGRAM_OFFICER_NAME: RANGANATHAN, SRIKANTH

PROJECT_TERMS: Actins;Affinity Chromatography;Antibodies;Binding;Biological Process;Blindness;Cell Nucleus;Cells;Characteristics;Column Chromatography;Communication;Complex;Coupled;Cytoplasm;Cytoskeletal Modeling;Cytoskeleton;Defect;Disease;DNA Repair Pathway;Dominant-Negative Mutation;Ensure;Enzymes;experimental study;Eye;F-Actin;fly;Functional disorder;Gene Expression;Genes;Genetic Transcription;Genome;Homologous Protein;Image;Immunoprecipitation;In Situ Hybridization;in vivo;insight;Knowledge;Lamins;Lead;life span;Link;Location;Mass Spectrum Analysis;Measures;Membrane;Messenger RNA;Molecular;mRNA Export;mutant;Mutate;Mutation;Nerve Degeneration;Nervous System;novel;novel therapeutics;Nuclear;Nuclear Inner Membrane;Nuclear Pore;Nuclear Pore Complex;Nuclear Protein;Pathway interactions;Phenotype;polyglutamine;polymerization;Polymers;prevent;promoter;protein complex;Proteins;Publishing;recruit;Regulation;Regulatory Pathway;repaired;Reporter;Retina;Role;SAGA;SCA7 protein;Shapes;Site;spatiotemporal;Symptoms;System;Tail;Testing;Tissues;Transcript;Transcription Coactivator;ubiquitin isopeptidase;Visualization;WAVE protein

PROJECT_TITLE: Mechanism and effects of communication between actin and gene regulatory complexes

STUDY_SECTION: SYN

STUDY_SECTION_NAME: Synapses, Cytoskeleton and Trafficking Study Section[SYN]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Prevention;Social Determinants of Health

PHR: PROJECT NARRATIVE This five-year study aims to understand how social and structural determinants of health influence mobility patterns among adolescents and young adults living with HIV (AYA-HIV) in Tennessee, and how these patterns influence HIV care outcomes. Through a mixed-methods approach – integrating geospatial monitoring, in-depth interviews, population-level data, and clinical data – we will examine how personal and residential mobility affects HIV care outcomes. Elucidating these relationships will inform the development of targeted interventions to address disparities among mobile AYA-HIV and contribute to efforts to end the HIV epidemic.

PI_NAMEs: AHONKHAI, AIMALOHI  (contact);CLOUSE, KATE

PROGRAM_OFFICER_NAME: MUJURU, PRISCAH

PROJECT_TERMS: Accounting;Acquired Immunodeficiency Syndrome;Address;Adolescent and Young Adult;Affect;Age;age group;aged;Attention;Automobile Driving;care outcomes;Caring;Case Manager;Categories;Cellular Phone;Censuses;Chronic;Clinical Data;cohort;Communities;Continuity of Patient Care;County;Data;design;Development;Disparity;Environment;Epidemic;Ethnic Origin;Ethnography;Exhibits;experience;Face;falls;Family;follow-up;Food Access;Foundations;Frequencies;General Population;Geography;Global Positioning System;Health;health care availability;HIV;Home;Housing;Incidence;Individual;Inequity;Infection;innovation;Intervention;Interview;Link;Literature;Measures;Mediator;member;Methods;Minority Groups;Modeling;Monitor;Movement;multidisciplinary;Neighborhoods;novel;Outcome;Pathway interactions;Pattern;Persons;Phenotype;Population;Prevalence;Prospective cohort;Public Health;Publishing;Qualitative Methods;Race;Recurrence;Research;Residential Mobility;response;Role;Sexual and Gender Minorities;social;social determinants;social factors;social stigma;Statistical Methods;structural determinants;structural health determinants;Structural Racism;Subgroup;surveillance data;Tennessee;Testing;United States;Viral;Work

PROJECT_TITLE: Understanding the relationship between individual, social, and structural determinants of health, mobility, and HIV outcomes among adolescents and young adults living with HIV in Tennessee


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Clinical Research

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: The fellows and mentors trained by this program will contribute to short- and long-term improvements in global health. In collaboration with 21 low- and middle-income country institutions, fellows’ research will help develop clear and effective programs and policies to advance global public health, including care for HIV, other infectious diseases, noncommunicable diseases, global surgery, cancer, mental health and addiction, sexual and reproductive health, and planetary health.

PI_NAMEs: COHEN, CRAIG R (contact);LEE, SUNG-JAE ;MARTIN, NATASHA ;MARTÍNEZ-LÓPEZ, BEATRIZ

PROGRAM_OFFICER_NAME: HAYES, UNJA

PROJECT_TERMS: burden of illness;California;career;career development;Collaborations;Country;Dentistry;design;Discipline;Discipline of Nursing;Ensure;Environmental Science;Equity;Evaluation;experience;faculty mentor;Faculty Recruitment;Fellowship;Fostering;Funding;global health;Goals;hands on research;Health;improved;Income;innovation;Institution;Instruction;Interdisciplinary Education;Leadership;Los Angeles;Medicine;Mentors;Mentorship;Modeling;National Institute of Biomedical Imaging and Bioengineering;online course;Personal Satisfaction;Postdoctoral Fellow;pre-doctoral;programs;Public Health;Race;recruit;Research;Research Methodology;Resources;response;San Francisco;Site;Social Sciences;success;Training;Training and Education;Training Programs;Underrepresented Minority;Universities;veterinary science;Work

PROJECT_TITLE: GloCal - NIBIB - Wambi

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(58)-R]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention

ORG_CITY: HANOVER

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PI_NAMEs: KARAGAS, MARGARET RITA (contact)

PROGRAM_OFFICER_NAME: KRASNOVA, IRINA N

PROJECT_TERMS: Acceleration;Achievement;Address;Adherence;Adoption;Advisory Committees;biobank;biomedical scientist;Cancer Center;career development;Centers of Research Excellence;Collaborations;commercialization;Communication;Communities;community advisory board;Decision Making;design;Disease;Disease Pathway;driving force;Early identification;Educational workshop;Ensure;Epidemiologist;equity, diversity, and inclusion;Etiology;Evaluation;Fostering;Funding;Future;Generations;Goals;Health;health care delivery;health inequalities;Health system;Human;human disease;Human Resources;human subject protection;improved;Infrastructure;Institution;International;Leadership;Measures;medical schools;member;Mentors;Mission;Molecular;Molecular Epidemiology;Monitor;operation;Pathogenesis;Performance;Pilot Projects;Policies;Procedures;Productivity;programs;Recommendation;recruit;Reporting;Research;research and development;Research Personnel;Research Priority;Resource Development;resource guides;Resource Sharing;Resources;Safety;Scientist;Services;Strategic Planning;Structure;symposium;synergism;Talents;Technology;Training;Translations;United States National Institutes of Health;Work

PROJECT_TITLE: Core A: Administrative, Career Development, and Research  Integration Core


ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: MADISON

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Project Narrative This research project aims to study 180 persons from families with the rare genetic disease named CADASIL. Images of the retina will be obtained and analyzed using both traditional and novel methods to develop new potential measures of CADASIL that would be useful in clinical trials to select participants for study, to determine whether and when a treatment is working, and to better understand the underlying mechanisms of CADASIL.

PI_NAMEs: PAULSEN, JANE S (contact)

PROGRAM_OFFICER_NAME: XU, LEI

PROJECT_TITLE: Retinal biomarkers in monogenic vascular cognitive impairment and dementia

STUDY_SECTION_NAME: Special Emphasis Panel[ZFD1 OC-Z (04)]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: DURHAM

ORG_NAME: DURHAM VA MEDICAL CENTER

PHR: The COVID-19 pandemic presents fundamental threats to dialysis patients. Over 16,000 of enrolled Veterans with ESKD receive VA-financed dialysis, 80% of whom receive this life-sustaining treatment through VA Community Care providers. Prior work found lower rates of survival among Veterans receiving dialysis exclusively in non-VA settings compared to VA dialysis, which may be due to fragmented and siloed care structures in community compared to the VA’s integrated healthcare system. Patients with kidney failure are particularly vulnerable to COVID-19 infection and related morbidity and mortality, are already prone to fragmented care, and especially susceptible to disrupted care. This study addresses an urgent need to examine the extent and impact of pandemic-related disruptions in care on disparities in outcomes among Veterans receiving dialysis treatment in VA and VA Community Care settings. Findings will inform how VA manages care for Veterans in disaster scenarios for this vulnerable and uniquely healthcare reliant population of patients.

PI_NAMEs: TRIVEDI, AMAL N.;WANG, VIRGINIA  (contact)

PROJECT_TERMS: access disparities;Acute;acute COVID-19;Address;Affect;Ambulatory Care;Area;Authorization documentation;Blood Vessels;care delivery;care fragmentation;care providers;care systems;Caring;Chronic;Clinic;Clinical;cohort;Collaborations;Communities;Community Financing;Community Healthcare;community setting;Comparative Study;Complex;Computerized Medical Record;COVID-19;COVID-19 impact;COVID-19 morbidity;COVID-19 pandemic;COVID-19 susceptibility;COVID-19 vaccination;Critical Care;Data;Dedications;Diagnostic;Dialysis patients;Dialysis procedure;Disasters;Disease Management;Disparity;Economically Deprived Population;Emergency Situation;End stage renal failure;Enrollment;ethnic disparity;ethnic minority;Evaluation;experience;Frequencies;Future;Health;health equity;Health Personnel;Health Services Accessibility;Health Services Administration;Healthcare;Immunocompromised Host;Improve Access;improved;Integrated Health Care Systems;Intervention;Kidney;Kidney Diseases;Kidney Failure;Life;Longitudinal cohort study;Maintenance;Managed Care;medical specialties;Medicare;Methodology;military veteran;Morbidity - disease rate;mortality;multiple chronic conditions;Nature;Neighborhoods;Outcome;outcome disparities;pandemic disease;pandemic disruption;pandemic impact;participant enrollment;patient population;Patient Transfer;Patients;Patterns of Care;Phase;Policies;Predisposition;Primary Care;Private Sector;Procedures;Process;programs;Provider;Public Health;racial disparity;racial minority;Recovery;Renal function;Research;Resources;Risk Factors;SARS-CoV-2 exposure;SARS-CoV-2 infection;Services;Shapes;social;social health determinants;Social Work;socioeconomic disadvantage;socioeconomic disparity;Socioeconomic Status;Structure;Survival Rate;System;tertiary care;Time;treatment adherence;Vaccines;Veterans;Veterans Health Administration;Work

PROJECT_TITLE: Impact of COVID-era Disrupted Care on Disparities in Outcomes among Veterans with Kidney Failure

STUDY_SECTION_NAME: HSR-5 Health Care System Organization and Delivery and Women's Health[HSR5]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Mental Health;Neurodegenerative;Neurosciences;Substance Misuse;Tobacco;Tobacco Smoke and Health

PHR: PROJECT NARRATIVE  Persons living with HIV (PLWH) are 2-3 times more likely than the average population to use nicotine- containing products, and although nicotine use may improve HIV-associated neurocognitive disorders (HAND), it may also exacerbate neurobiological sequelae induced by HIV infection such as neuroinflammation despite use of anti-retroviral therapies (ART). The proposed research has the potential to uncover novel neurobiological mechanisms by which nicotine use alleviates some of the cognitive dysfunction associated with HIV infection but exacerbates neuroimmune dysregulations utilizing the EcoHIV virus in a rat model of nicotine use.

PI_NAMEs: GIPSON-REICHARDT, CASSANDRA D (contact)

PROGRAM_OFFICER_NAME: BORGMANN, KATHLEEN RUTH

PROJECT_TERMS: addiction;Adherence;Age;Amygdaloid structure;Animals;antiretroviral therapy;Anxiety;anxiety-like behavior;Brain;Cells;Chronic;Clinical;Cognition;Cognitive;cognitive change;cognitive enhancement;cognitive function;cognitive performance;cognitive task;comorbidity;Consequences of HIV;coping;Coping Skills;cytokine;Cytokine Suppression;Data;Drug usage;experience;Female;field study;Genes;Goals;HIV;HIV Infections;HIV-associated neurocognitive disorder;Immune;Immune system;Impaired cognition;Impairment;improved;Infection;Inflammation;Inflammatory;Intake;Macrophage;Measures;Memory;Mental Depression;Microglia;Modeling;motivated behavior;Motivation;neurobehavioral;neurobiological mechanism;Neurobiology;Neurocognition;Neurocognitive;Neurocognitive Deficit;Neuroimmune;Neuroimmune system;neuroinflammation;Nicotine;Nicotine Dependence;nicotine exposure;nicotine seeking behavior;nicotine self-administration;nicotine use;novel;Nucleus Accumbens;Outcome;Pathway interactions;Performance;Peripheral;Persons;Pharmacotherapy;Population;Pre-Clinical Model;preclinical evaluation;Prefrontal Cortex;Rattus;Reporting;Research;Rewards;Rodent;Rodent Model;Role;Saline;Sampling;Self Administration;Serum;sex;Shapes;Signal Transduction;Smoking;smoking cessation;smoking initiation;Testing;Ventral Striatum;Viral;Viral reservoir;Virus;Withdrawal;Woman;Work;years of life lost

PROJECT_TITLE: Neuroimmune and Cognitive Consequences of Nicotine Use in a Rodent Model of HIV: Implications for Anti-Retroviral Therapies


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: RELEVANCE (See instructions): Understanding the continuity of visual experience is a fundamental problem in the fields of vision, visual perception and visual consciousness. The proposed research will elucidate both local computations and communication between distributed brain networks supporting sustained visual perception The work will provide tools and theory for studying both normal and disordered visual processing and guidance for development of novel rehabilitation methods.

PI_NAMEs: BRUNNER, PETER ;SOMMER, FRIEDRICH T (contact)

PROGRAM_OFFICER_NAME: CLAYTON, EDWIN C

PROJECT_TERMS: Address;Affect;Area;Attention;Awareness;Brain;Brain region;Categories;Clinical;Cognition;Communication;computational basis;Computing Methodologies;Conscious;Consciousness Disorders;Coupling;Data;Data Analyses;Detection;Development;Dimensions;Electrocorticogram;Electrodes;Electroencephalography;Electrophysiology (science);experience;Fostering;Frequencies;Goals;graduate student;Human;Image;Implant;Individual;Instruction;Lateral;Measures;Medial;medial temporal lobe;Methods;Modeling;neglect;Nervous System Disorder;neural;neural model;neural patterning;neuromechanism;Neurons;neurotransmission;novel;novel strategies;Patients;Pattern;Perception;Phase;Process;Rehabilitation therapy;Research;response;sensory input;Site Visit;Software Tools;spatiotemporal;Stimulus;Structure;support network;Techniques;Temporal Lobe;Testing;theories;Time;tool;Training;undergraduate student;Vision;Vision Disorders;Visual;Visual Perception;visual processing;visual stimulus;Work

PROJECT_TITLE: CRCNS: Computations and Neural Mechanisms in Sustained Perception in Humans

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BN-P (50)]


ORG_CITY: GALVESTON

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

ORG_STATE: TX

PI_NAMEs: BUKREYEV, ALEXANDER  (contact)

PROGRAM_OFFICER_NAME: DUPUY, LESLEY CONRAD

PROJECT_TITLE: Research Project 1: Role of Epigenetic and Transcriptional Mechanisms in the Pathogenesis of Ebola Virus Disease


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Dental, Oral, and Craniofacial Disease;Neurosciences;Nutrition

ORG_CITY: WALTHAM

ORG_DEPT: PSYCHOLOGY

ORG_NAME: BRANDEIS UNIVERSITY

PHR: Project Narrative When a taste is placed on our tongues, we must recognize that a taste is on the tongue, identify that taste, decide whether it’s palatable or not, and then either swallow it or expel it. This thought process can be observed to play out in the firing of neurons in taste cortex, but evidence suggests that cortex doesn’t work alone. We will rigorously test how the amygdala (the seat of emotion in the brain) and hypothalamus (the center that controls hunger and thirst) work with cortex, and with one another, to make taste decisions happen, and how these decisions get implemented by motor circuits—adding to a systemic understanding of taste that will help us fight against a spectrum of feeding-related disorders.

PI_NAMEs: KATZ, DONALD B (contact)

PROGRAM_OFFICER_NAME: SABRI, MERAV

PROJECT_TERMS: Affect;Amygdaloid structure;Automobile Driving;awake;Axon;Back;Behavior;Biological;Brain;brain circuitry;Brain region;Brain Stem;cell type;Cells;central pattern generator;Code;Complex;Consumption;Coupled;Coupling;Decision Making;Deglutition;Disease;Dissociation;Eating;Electrophysiology (science);Emotions;experimental study;feeding;fighting;Food;Generations;Green Fluorescent Proteins;Hunger;Hypothalamic structure;insight;Lateral;Lighting;Mediating;Molecular;Monitor;Motor;Movement;Nature;neural;Neurons;Nonlinear Dynamics;novel;Optics;optogenetics;Oral;Oral cavity;orofacial;Output;Pathway interactions;Perception;Periodicity;Play;Population Dynamics;Process;Production;Property;Prosencephalon;Rattus;Reporting;Research Project Grants;response;Rodent;Role;Sampling;sensorimotor system;Signal Transduction;Site;Stimulus;Structure;sugar;sweet taste perception;System;Taste Perception;taste system;Testing;Thinking;Thirst;Time;Tongue;tool;Work

PROJECT_TITLE: Temporal Coding and Palatability in Gustatory Cortex


NIH_SPENDING_CATS: Behavioral and Social Science;HIV/AIDS;Prevention

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PI_NAMEs: JOHN-STEWART, GRACE C. (contact)

PROGRAM_OFFICER_NAME: WONG, ELAINE WAI-KEN

PROJECT_TITLE: B: Developmental


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Data Science;Health Services;Intellectual and Developmental Disabilities (IDD);Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Neurosciences;Pediatric;Prevention;Primary Health Care;Telehealth

ORG_DEPT: PSYCHIATRY

ORG_NAME: DUKE UNIVERSITY

PHR: PROJECT NARRATIVE – Overall The purpose of the renewal of the Duke Autism Center of Excellence is to apply cutting-edge, translational digital health and computational methods to develop more effective tools for early autism screening and for objectively monitoring changes in children’s behavior, and to discover novel, brain-based biomarkers that can be used for stratification and to assess target engagement in clinical trials with young autistic children. Our long-term vision is to transform how clinical care is delivered by providing innovative solutions that address long-standing barriers in access to care and enhance our ability to evaluate interventions that will improve quality of life of autistic children and their families.

PI_NAMEs: DAWSON, GERALDINE  (contact)

PROGRAM_OFFICER_NAME: KAU, ALICE S

PROJECT_TERMS: 6 year old;Address;Age;Age Months;autism biomarker;autism spectrum disorder;autistic;autistic children;Automated Clinical Decision Support;Behavior;behavioral outcome;Biological Markers;biomarker discovery;Birth;Blue Cross;Blue Shield;Brain;brain based;Caregivers;Caring;Child;Child Behavior;Clinical;clinical care;clinical decision support;Clinical Trials;Code;Collaborations;computer science;Computer Vision Systems;Computing Methodologies;Data;Data Analyses;data management;Data Science;Data Set;design;Development;Devices;Diagnosis;digital applications;digital health;digital phenotyping;Discrimination;Early Diagnosis;Early identification;Electroencephalography;electronic health data;Electronic Health Record;Elements;Engineering;Equity;Ethnic Origin;Factor Analysis;Family;Future;gastrointestinal;Goals;health data;Health Services Accessibility;Health system;Home;implementation science;improved;indexing;Infant;innovation;insight;Intellectual functioning disability;Intervention;Language;literacy;Machine Learning;machine learning method;Measures;Medicaid;Medical;member;Methods;Monitor;multimodality;Natural Language Processing;Nature;neglect;neural;neural network;Neurosciences;North Carolina;novel;novel strategies;Outcome;Outcome Measure;outreach;Parent-Child Relations;Participant;Pathway Analysis;Pattern;Pediatrics;Phase;Population;Population Heterogeneity;prediction algorithm;predictive modeling;Predictive Value;Prevalence;primary care clinic;primary care provider;Provider;Psychiatry;Psychology;Qualifying;Quality of life;Questionnaires;Race;recruit;remote administration;Research;screening;Screening procedure;sex;social attention;Stratification;success;support tools;Testing;Toddler;tool;Universities;usability;Video Recording

PROJECT_TITLE: Duke Autism Center of Excellence: A translational digital health and computational approach to early identification, outcome monitoring, and biomarker discovery in autism


ORG_CITY: CORAL GABLES

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: Public Health Relevance Statement (PROJECT NARRATIVE) The proposed research will study the involvement of CCL2 in modulating monocyte recruitment to the BBB in the context of HIV infection as targets for stroke susceptibility. The central hypothesis is that that astrocyte- specific CCL2/CCR2 signaling modulates HIV-associated stroke severity and functional recovery by regulating monocyte recruitment to the BBB, inflammasome activation, and modulating innate immune responses. The findings resulting from this proposal will help to identify promising new therapeutic targets in ischemic stroke associated with HIV infection.

PI_NAMEs: TORICES, SILVIA  (contact)

PROGRAM_OFFICER_NAME: DALEY, WILLIAM PATRICK

PROJECT_TERMS: Ablation;Acceleration;Acute;Address;Astrocytes;beta-Chemokines;Blood - brain barrier anatomy;Blood Cells;blood-brain barrier disruption;blood-brain barrier permeabilization;Brain;brain cell;Brain Injuries;Brain Ischemia;Cause of Death;CCR5 gene;cell type;Cells;Cessation of life;chemokine;Chemosensitization;Chemotactic Factors;Chronic;conditional knockout;cytokine;Death Rate;Dimethyl Sulfoxide;experience;Genes;Glial Fibrillary Acidic Protein;high risk;HIV;HIV Infections;hospitalization rates;humanized mouse;Immune;Infiltration;Inflammasome;Inflammation;Inflammatory;Inflammatory Response;inhibitor;Injections;Injury;Innate Immune Response;innovation;Interferons;ischemic injury;Ischemic Stroke;Knockout Mice;Lateral;Leukocytes;Ligands;Long-Term Effects;LoxP-flanked allele;Macrophage;Microglia;Middle Cerebral Artery Occlusion;migration;Modeling;monocyte;monocyte chemoattractant protein 1 receptor;mouse model;Mus;Natural Immunity;neuroinflammation;new therapeutic target;novel;Pathway interactions;Patients;Persons;Play;post stroke;Predisposition;prevent;Production;public health relevance;RANTES;Recovery of Function;recruit;Research;response;Role;Severities;Signal Transduction;Stroke;stroke outcome;stroke recovery;Stroke Volume;Tail;targeted treatment;therapeutic target;Transgenic Mice;Up-Regulation;Veins;Viral Load result;Virus Replication

PROJECT_TITLE: CCL2/CCR2 modulates HIV-associated ischemic stroke by regulating blood brain barrier monocyte recruitment


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Disability Research;Dissemination and Implementation Research;Health Services;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric;Prevention

ORG_NAME: UNIVERSITY OF MASSACHUSETTS BOSTON

PHR: Project Narrative Despite strong consensus that early, specialized intervention for children with Autism Spectrum Disorder (ASD) can have a dramatic impact on outcomes, the public health system’s capacity to provide such services is severely challenged by the rapid rise in ASD prevalence. The goal of this research is to increase timely and equitable access to ASD-specialized early intervention during the critical first three years of life by capitalizing on the existing infrastructure of the Part C Early Intervention (EI) system, which is publicly funded and available in all U.S. States. This project will train EI providers to use an evidence-based, inexpensive, parent-mediated intervention that can improve child and family outcomes as well as mitigate the substantial economic costs associated with ASD.

PI_NAMEs: CARTER, ALICE S. (contact)

PROGRAM_OFFICER_NAME: PUGLIESE, CARA ELISABETH

PROJECT_TERMS: acceptability and feasibility;Address;Aftercare;Age;Area;autism spectrum disorder;autism symptoms;autistic children;Behavior;Behavior Therapy;Birth;Characteristics;Child;Child Language;Child Rearing;clinically relevant;Code;Consensus;Consensus Development;Consultations;Data;data management;Development;Developmental Delay Disorders;Developmental Disabilities;dosage;Early Intervention;economic cost;Educational process of instructing;Effectiveness;effectiveness evaluation;effectiveness testing;effectiveness/implementation design;effectiveness/implementation hybrid;Equity;evidence base;Evidence based intervention;Family;Family member;follow-up;Funding;Future;Goals;Health system;Heterogeneity;Home;hybrid type 1 design;Hybrids;implementation determinants;implementation evaluation;improved;improved outcome;Individuals with Disabilities Education Act;Infrastructure;innovation;Intervention;intervention program;Interview;joint attention;Language;Language Development;language outcome;Lead;Learning;Life;Measures;Mediating;member;Methods;Modification;Motor;multi-site trial;National Institute of Mental Health;Outcome;Parents;Patient Self-Report;Personal Satisfaction;Play;Population;Prevalence;Procedures;Protocols documentation;Provider;provider intervention;Public Health;quality assurance;Quality of life;Randomized;randomized, clinical trials;Randomized, Controlled Trials;Reporting;Research;Role;Sample Size;Sampling;Self Efficacy;service delivery;service intervention;Services;Site;social communication;Source;Stress;System;Technology Assessment;Testing;Training;treatment as usual;treatment effect;Variant

PROJECT_TITLE: 4/4: Improving the Part C Early Intervention Service Delivery System for Children with ASD: A Randomized Clinical Trial


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: DREXEL UNIVERSITY

PHR: PROJECT NARRATIVE Latino/a/e (“Latine”) sexual and gender minority persons (SGM), specifically men and transgender women who have sex with men, face inequities in HIV prevention and treatment outcomes. Although strategies for Ending the HIV Epidemic in the United States recognize that stigma and discrimination at multiple levels shape such inequities, research on structural stigmatization and discrimination has been hampered by measurement challenges. Our project aims to develop, validate, and apply state-level measures of structural stigmatization and discrimination for Latine and SGM populations that can be applied to health equity research across multiple conditions.

PI_NAMEs: DEL RIO-GONZALEZ, ANA MARIA ;SCHEIM, AYDEN I (contact)

PROGRAM_OFFICER_NAME: BARKSDALE, CRYSTAL

PROJECT_TERMS: Address;AIDS prevention;American;Attitude;Behavioral Risk Factor Surveillance System;Bisexual;Black race;Caring;Communities;community advisory board;community engaged approach;community engagement;community organizations;Consensus;Criminal Law;Data;Data Set;data sharing;Delphi Study;Diagnosis;Dimensions;Discrimination;Disparity;Distress;economic indicator;Ensure;Epidemic;Epidemiologic Methods;Equation;experience;Face;Gays;gender minority community;gender minority group;gender minority health;Geography;Goals;Guidelines;Health;Health equity research;HIV;HIV diagnosis;HIV Infections;Immigration;improved;Income;indexing;Individual;Inequity;Internet;intersectionality;Intervention;Knowledge;Latino;Latinx;Laws;Least-Squares Analysis;Legal;Measurement;Measures;meetings;member;men;Mental Health;Methods;Modeling;Outcome;Patient Self-Report;perceived discrimination;Persons;Policies;Policy Maker;Population;pre-exposure prophylaxis;Psyche structure;Public Health;Public Opinion;Race;racism;Reproducibility;Research;Research Personnel;Science;Sexual and Gender Minorities;sexual minority group;sexual minority men;Shapes;social;Social status;social stigma;Stigmatization;structural determinants;Surveys;systematic review;transgender;transgender women;transgender women who have sex with men;translational approach;treatment disparity;Treatment outcome;United States;Viral;Work

PROJECT_TITLE: Measures of structural stigmatization and discrimination for HIV research with Latine sexual and gender minorities


NIH_SPENDING_CATS: HIV/AIDS

PI_NAMEs: CELUM, CONNIE L (contact)

PROJECT_TITLE: A: Administrative


NIH_SPENDING_CATS: Behavioral and Social Science;Climate-Related Exposures and Conditions;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PHR: Project Narrative: This study investigates the disruptions and displacement effects of natural events and their influence on HIV treatment continuity and mental health in Puerto Rico (PR) using electronic health records. It also explores the role of social networks in HIV care and mental health continuity during natural events, aiming to develop an intervention prototype with implementation and dissemination recommendations based on findings. Dr. Casanova will acquire training in longitudinal analysis, social network analysis, and intervention design for achieving these research aims.

PI_NAMEs: CASANOVA, FELICIA  (contact)

PROGRAM_OFFICER_NAME: WHITE, DOLLY PENN

PROJECT_TERMS: Address;Affect;Appointment;Area;Automobile Driving;Black race;care providers;career;career development;Caring;Climate;climate change;Communities;community advisory board;Community Healthcare;community organizations;Community Services;Competence;Continuity of Patient Care;culturally appropriate intervention;Data;Development;Disasters;Disparity;Dissemination and Implementation;Earthquakes;Electronic Health Record;Environmental Exposure;environmental health disparity;Epidemic;Equity;Event;evidence base;experience;extreme weather;Faculty;Floods;Focus Groups;Funding;Goals;Government;Health;health assessment;health care availability;health care service;health care service utilization;Health Disparities Research;health disparity;health equity;Health Promotion;HIV;HIV disparities;Hurricane;Immigrant community;implementation science;improved;Incidence;Individual;Inequity;Intervention;Interview;Knowledge acquisition;Latinx;Link;longitudinal analysis;Mental Health;Mental Health Services;Mentors;Mentorship;Methods;minority health;minority health disparity;Modeling;mortality;Natural Disasters;novel strategies;Outcome;Pathway Analysis;Personal Satisfaction;Persons;Play;Population;Privatization;prototype;Provider;Puerto Rico;Readiness;Recommendation;Recovery;Reporting;Research;Research Personnel;Research Priority;Research Project Grants;resilience;response;Role;rural area;Secure;service delivery;service gap;skills;social;social culture;Social Network;Support System;System;tenure track;Testing;therapy design;therapy development;Training;treatment adherence;United States;urban area;Visualization;Work

PROJECT_TITLE: Addressing Disaster Displacement for Recovery with Equitable and Sustainable Systems (ADDRESS) of HIV Care in Puerto Rico

STUDY_SECTION_NAME: Special Emphasis Panel[ZMD1 DRI (O1)]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Dissemination and Implementation Research;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Opioid Misuse and Addiction;Opioids;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Newly formed probation services in Eastern Europe, where the HIV epidemic continues to expand, provide a unique opportunity to reduce HIV transmission by linking people with opioid use disorder to opioid agonist therapy (OAT) while promoting decarceration efforts. Dr. Azbel's two proposed research aims use the EPIS framework to understand the influence of the inner (clients, officers, criminal subculture) and outer contexts (probation leadership and OAT clinic staff), as organizational process changes are introduced via NIATx, on the implementation of a screening-engagement-treatment (SET) strategy for OAT scale-up among probation clients in Georgia and Moldova. This K01 seeks support for enhanced coursework, seminars, interdisciplinary mentorship, and research experience to bolster the candidate’s ability to emerge as an independent researcher, leveraging newly acquired training in ethnography, implementation science, and mixed methods to inform implementation strategies of evidence-based HIV prevention practices in community supervision settings.

PI_NAMEs: AZBEL, LYUBA  (contact)

PROGRAM_OFFICER_NAME: LEE-WINN, ANGELA EUNJI

PROJECT_TERMS: Adoption;AIDS prevention;career;career development;Central Asia;Certification;Client;Clinic;Collaborations;Communities;community setting;Complex;Country;Crime;Criminal Justice;cultural competence;Drug usage;Drug user;Eastern Europe;Ensure;Environment;Epidemic;Epidemiology;ethnographic method;Ethnography;Europe;Evaluation;evidence base;Evidence based practice;Evolution;experience;Exploration, Preparation, Implementation, and Sustainment;Foundations;Funding;global health;Goals;Health;high risk;HIV;HIV risk;Hybrids;implementation context;implementation research;implementation science;implementation strategy;implementation tool;Imprisonment;improved;Incidence;Individual;Injecting drug user;Injections;innovation;International;Interpersonal Relations;Intervention;Interview;Kyrgyzstan;Leadership;Link;medication for opioid use disorder;meetings;Mentorship;Methods;Modeling;Moldova;mortality;opioid agonist therapy;opioid use;opioid use disorder;Patients;personalized approach;Persons;Pharmaceutical Preparations;Population;prevention practice;Prevention strategy;preventive intervention;Prisons;probation;Procedures;Process;Production;Productivity;prospective;Public Health;Rapid screening;Reporting;Research;Research Methodology;Research Personnel;Research Project Grants;response;Risk;Role;Safety;scale up;screening;Secure;Services;Shapes;skill acquisition;skills;social;sociologist;Structure;substance use;success;Supervision;Surveys;Techniques;Testing;theories;Training;transmission process;treatment strategy;Trust;Ukraine;uptake

PROJECT_TITLE: Innovations in Implementing Medications for Opioid Use Disorder for HIV Prevention in Probation Settings in Eastern Europe


ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE Anti-HIV broadly neutralizing antibodies (bNAbs) demonstrate potential for effective virus suppression and reservoir depletion when used early in conjunction with combined antiretroviral therapy (cART), which provides effective treatment for infants. However, their effectiveness in deep tissue reservoirs, particularly in targeting infections within the central nervous system (CNS), is limited due to insufficient concentrations caused by the blood-brain barrier. We propose a novel nanotechnology approach, called 'nanocapsules,' designed to enhance the delivery of bNAbs directly to the CNS, potentially leading to the remission of HIV from CNS reservoirs. Page 1 of 1

PI_NAMEs: HESSELL, ANN JONES;WEN, JING  (contact)

PROJECT_TERMS: Adult;Aftercare;Anatomy;Animal Model;Antibodies;Antibody Therapy;antiretroviral therapy;antiviral immunity;Bar Codes;Binding;Bioinformatics;Birth;Blood;Blood - brain barrier anatomy;blood-brain barrier penetration;Brain;Cells;Central Nervous System;Cerebrospinal Fluid;choline analog;choline transporter;Clinical Trials;Clonal Expansion;Clone Cells;Collaborations;Complement;critical period;Data;design;Development;Disease;Disease Progression;Disease remission;Dissection;Early Intervention;Early treatment;effective therapy;Effectiveness;effectiveness evaluation;efficacy evaluation;Encapsulated;experience;Genes;Grant;HIV;HIV Infections;HIV-1;Hour;immune activator;Immune response;Immune system;Immunotherapy;improved;Incidence;Individual;Infant;Infection;integration site;Intervention;intravenous administration;Kinetics;Libraries;lymph nodes;Malignant neoplasm of brain;Medical;member;Methods;Mississippi;Modeling;Molecular Biology;Monoclonal Antibodies;mortality;nanocapsule;nanoencapsulated;Nanotechnology;neonatal immune system;Nerve;Nervous System Disorder;neurodevelopment;neuroinflammation;Neurologic Symptoms;neutralizing antibody;Newborn Infant;nonhuman primate;novel;novel therapeutic intervention;Nucleotides;Passive Immunization;Pathogenesis;Penetration;Peripheral;peripheral blood;Physiology;Polymers;Population;prevent;Research Design;Resource-limited setting;response;Shock;simian human immunodeficiency virus;success;Surface;System;Technology;Therapeutic;Thinness;Time;Tissues;Toxic effect;Treatment Efficacy;Vertical Transmission;Viral;Viremia;Virus;Virus Diseases;Virus Integration

PROJECT_TITLE: Improved delivery of bNAbs for targeting CNS infection in infants

STUDY_SECTION: HIVD

STUDY_SECTION_NAME: HIV Immunopathogenesis and Vaccine Development Study Section[HIVD]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Dissemination and Implementation Research;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Mental Health;Prevention;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative Recent literature indicates that people living with HIV are more likely to be smokers, use substances at higher rates, derive less benefit from antiretroviral therapy, report significantly poorer medication adherence, and have poorer clinical outcomes for many non-AIDS related conditions (e.g., lung cancer, cardiovascular disease). However, engagement in evidence-based behavioral interventions may work to address some of these negative outcomes. The present K24 proposal would allow me to accommodate increasing requests for mentorship from trainees and junior faculty, as well as provide an additional platform for involving my mentees in substance use bio-behavioral research in the context of HIV.

PI_NAMEs: O'CLEIRIGH, CONALL MICHAEL (contact)

PROGRAM_OFFICER_NAME: FITZ-RANDOLPH, MARCY ESTHER

PROJECT_TERMS: 3-Dimensional;Acquired Immunodeficiency Syndrome;Address;Administrator;AIDS prevention;antiretroviral therapy;Award;Behavior Therapy;Behavioral;Behavioral Medicine;biobehavior;Cardiovascular Diseases;Caring;CD4 Lymphocyte Count;Cessation Research;Clinical;Clinical assessments;Clinical Investigator;Clinical Psychology;Clinical Research;clinical research site;Clinical Treatment;cohort;Collaborations;Collection;community science;Computerized Medical Record;Country;COVID-19 pandemic;Data;Data Analyses;Data Collection;Data Sources;Discipline;Disease Management;Disease Outcome;Effectiveness;efficacy evaluation;efficacy testing;evidence base;experience;Faculty;Fellowship;Funding;General Hospitals;Grant;Health;health disparity;HIV;HIV/TB;Home;implementation facilitators;implementation intervention;implementation science;Individual;Infrastructure;Institution;interest;International;Internships;Intervention;intervention delivery;Interview;Literature;Malignant neoplasm of lung;Massachusetts;Mediator;Medical;medication compliance;Mental Health;Mentors;Mentorship;Modality;multidisciplinary;National Institute of Drug Abuse;Neighborhood Health Center;novel;Outcome;patient oriented;Patient Outcomes Assessments;Persons;Phase;Physicians;Positioning Attribute;Postdoctoral Fellow;pre-doctoral;Prevention;primary care clinic;programs;Provider;Psychiatry;Psychology;Public Health;public health priorities;Publications;recruit;Reporting;Research;research and development;Research Methodology;Research Personnel;Research Project Grants;research study;Role;Site;skills;Smoke;Smoker;Smoking;smoking cessation;Smoking Cessation Intervention;Smoking Status;South Africa;substance use;substance use treatment;syndemic;System;Testing;therapy adherence;therapy development;Thinness;Time;Tobacco smoke;Tobacco use;Training;Training Programs;treatment effect;Treatment outcome;treatment research;tuberculosis treatment;United States National Institutes of Health;Universities;viral rebound;virtual;virtual delivery;virtual intervention;Work

PROJECT_TITLE: Patient-Oriented Substance Use/Smoking Cessation Research in HIV Treatment and Prevention

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Digestive Diseases;HIV/AIDS;Infectious Diseases;Liver Disease;Lung;Substance Misuse

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

PHR: PROJECT NARRATIVE Heavy alcohol use is associated with increased respiratory symptom burden in people living with HIV (PLWH), and alcohol increases the risk of sepsis and multimorbidity of the lungs and liver in PLWH. In this proposal, the PI will determine if alcohol and HIV induce apoptosis of lung immune cells, alveolar macrophages, and promote the release of extracellular vesicles which impair alveolar epithelial barrier function, causing lung leak, and potentiate liver injury; thereby exacerbating lung injury. The findings from the study will not only identify potential treatment strategies for PLWH with AUD but also raise awareness of the impact of alcohol misuse on HIV-induced multi-organ damage.

PI_NAMEs: NEW-AARON, MOSES O (contact)

PROGRAM_OFFICER_NAME: LIN, LI

PROJECT_TERMS: Acetaldehyde;Acquired Immunodeficiency Syndrome;Address;adduct;Alcohol consumption;alcohol effect;alcohol exposure;alcohol misuse;alcohol research;alcohol testing;alcohol use disorder;Alcohols;Alveolar;alveolar epithelium;Alveolar Macrophages;Alveolus;antiretroviral therapy;Apoptosis;Apoptotic;Applications Grants;Award;Awareness;career;Career Mobility;Caring;Cell Death;Cells;chronic alcohol ingestion;Chronic Disease;Circulation;Communicable Diseases;Communication;Consumption;cytokine;Data;Epithelial Cells;Epithelium;Ethanol Metabolism;Event;exosome;extracellular vesicles;Financial Hardship;Functional disorder;Funding Mechanisms;Goals;Grant;Health;healthcare burden;Healthcare Systems;Heavy Drinking;Hepatic;Hepatic Stellate Cell;Hepatocyte;HIV;HIV Infections;Immune;Immune System Diseases;Impairment;in vivo;Individual;Induction of Apoptosis;Infection;Inflammation Mediators;Inflammatory Response;Injury;Knowledge;Laboratories;Link;Lipopolysaccharides;Liver;liver inflammation;liver injury;Longevity;Lung;lung injury;Lysosomes;Malondialdehyde;MAPK3 gene;Mediating;meetings;Molecular;Molecular Target;mortality;mouse model;multiorgan damage;multiple chronic conditions;National Institute on Alcohol Abuse and Alcoholism;National Research Service Awards;non-smoking;Organ;pathogen;Pathway interactions;Pattern;Persons;Phase;post-doctoral training;pre-doctoral;preclinical study;programs;Proteins;Public Health;Pulmonary Inflammation;Reactive Oxygen Species;Reporting;Research;Research Personnel;Respiratory Signs and Symptoms;response;Risk;Role;Sepsis;skills;Source;Stress;substance misuse;Symptom Burden;systemic inflammatory response;Techniques;Testing;Training;Transcript;treatment strategy;vesicular release;Viremia

PROJECT_TITLE: Alcohol metabolism potentiates HIV-induced lung and liver multimorbidity via inter-organ crosstalk


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Mental Health;Mental Illness;Neurosciences

ORG_STATE: NC

PHR: We propose to create an approach for directly regulating the transfer of electrical information across neural circuits that encode emotions. After creating this new method for rewiring synapses, we will deploy it in animal models of psychiatric disorders. Thus, our high-risk research has the potential to yield a new therapeutic strategy for treating mental illnesses such as depression, anxiety, and addiction.

PI_NAMEs: DZIRASA, KAFUI  (contact)

PROGRAM_OFFICER_NAME: DRISCOLL, JAMIE DANIELLE

PROJECT_TERMS: addiction;Address;Animal Model;Anxiety;Behavior;Brain;brain cell;cell type;Cells;Connexins;designer receptors exclusively activated by designer drugs;Docking;Electrical Engineering;Electrical Synapse;Emotional;emotional behavior;Emotions;Engineering;Exhibits;experimental study;Future;high risk;Individual;member;Mental Depression;Mental disorders;Methods;model organism;neural circuit;neuroregulation;novel;novel strategies;novel therapeutic intervention;optogenetics;Physiology;Pre-Clinical Model;prevent;Property;Proteins;Research;Synapses;Testing;tool;translation to humans;Viral

PROJECT_TITLE: Precision editing of neural circuits using engineered electrical synapses


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;HIV/AIDS;Infectious Diseases;Neurosciences;Prevention

ORG_CITY: MIAMI

ORG_NAME: FLORIDA INTERNATIONAL UNIVERSITY

PHR: PROJECT NARRATIVE Over 45% of people living with HIV (PLWH) in the United States are over 50 years old and at heightened risk of aging-related comorbidities. The goal of this exploratory grant is to investigate whether the hyperactivation of the autophagy pathway can delay age-related phenotypes and cognitive decline in HIV-infected adult and old mice.

PI_NAMEs: EL-HAGE, NAZIRA ;RODRIGUEZ, MYOSOTYS  (contact)

PROGRAM_OFFICER_NAME: MARIC, MAJA

PROJECT_TERMS: Adult;Aftercare;Age Months;age related;Age related comorbidities;aged;Aging;aging population;aging related;AIDS prevention;Alzheimer's Disease;Amyloid;Animals;antiretroviral therapy;Apoptotic;Autophagocytosis;Autopsy;BCL2 gene;behavior test;Behavioral;BH3 Domain;Binding;Biological Markers;Brain;Cardiac;CCL2 gene;Cell Culture Techniques;Cell Death;Cerebral hemisphere;Chronic;Cognition;Cognitive;cognitive performance;comorbidity;Complex;cyclooxygenase 2;Degradation Pathway;Deposition;Development;Enzyme-Linked Immunosorbent Assay;experimental study;extend lifespan;Family;Family member;Female;Flow Cytometry;Functional disorder;Glial Fibrillary Acidic Protein;Glutamates;Goals;Grant;Health;healthspan;Hematoxylin and Eosin Staining Method;HIV;HIV Infections;HIV-associated neurocognitive disorder;immune activation;Immunohistochemistry;Impaired cognition;Impairment;improved;Individual;Infection;Inflammaging;Inflammation;Inflammatory;inflammatory marker;inhibition of autophagy;inhibitor;Interleukin-6;Kidney;Knock-in;Knock-in Mouse;Knowledge;Life Expectancy;life span;Location;Longevity;male;Mammals;Measures;Mediating;member;metabotropic glutamate receptor 2;model organism;mouse model;Mus;N-Methyl-D-Aspartate Receptors;Nerve Degeneration;Neurocognitive;Neuroglia;neuroinflammation;Neurologic;neuronal cell body;neurotransmission;Nitric Oxide Synthase;novel;nuclear factor-erythroid 2;object recognition;old mice;older adult;Older Population;Organelles;Outcome;Oxidative Stress;Pathogenesis;Pathologic;Pathology;Pathway interactions;Patients;Persons;Phenotype;Play;Premature aging syndrome;prevent;Prevention;Proteins;Public Health;Reporting;Risk;Role;Saline;Scientist;Stains;Stress;success;superoxide dismutase 1;Synaptic plasticity;Testing;Therapeutic;Time;Tissues;TNF gene;tumorigenesis;United States;Virus Replication;Western Blotting

PROJECT_TITLE: Reduction of the Beclin1-BCL2 complex in the prevention of HIV and comorbidities associated with aging


ED_INST_TYPE: SCH OF HOME ECON/HUMAN ECOLOGY

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Pediatric;Prevention;Rural Health;Social Determinants of Health;Substance Misuse

ORG_CITY: ATHENS

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF GEORGIA

ORG_STATE: GA

PHR: Project Narrative: This research will examine how early hormonal changes during childhood, influenced by socioeconomic hardships, can increase the risk of developing drug use problems in adolescence. Understanding these connections can inform prevention and targeted interventions to protect vulnerable children and ultimately reduce future addiction rates, particularly in underserved rural communities.

PI_NAMEs: OSHRI, ASSAF  (contact)

PROGRAM_OFFICER_NAME: PARIYADATH, VANI

PROJECT_TERMS: addiction;Adolescence;Affect;Age;Biology;career;Child;Child Health;Childhood;Data;Data Analyses;dehydroepiandrosterone;Development;Disparity;doctoral student;Drug usage;drug use vulnerability;early life adversity;empowerment;Face;Functional Magnetic Resonance Imaging;Future;Hormonal;Hormonal Change;Intervention;Low income;Measures;Modeling;neurobehavioral;Neurosciences;Neurosecretory Systems;Prevention;Process;promote resilience;Puberty;Research;resilience;Resources;Rewards;Risk;Rural;rural area;Rural Community;rural environment;rural underserved;Scientist;skills;socioeconomics;Stress;Testing;Training;Universities;Work

PROJECT_TITLE: Early Adversity and Drug Use Vulnerability Among Low Income Rural Children: Testing a Neuro-ecological Model of Resilience


NIH_SPENDING_CATS: Genetics;Lung;Pulmonary Fibrosis;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: NEW ORLEANS

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: Idiopathic pulmonary fibrosis (IPF) is the most common and lethal form of the fibrotic lung diseases that is associated with loss/dysfunction of lung stem cells. The proposed study aimed to explore the molecular mechanisms by which stem cells are dysregulated in lung fibrosis. The ultimate goal of this work is to provide new interventions and therapeutic approaches to prevent, treat, and potentially reverse fibrotic lung diseases.

PI_NAMEs: ZHOU, YONG  (contact)

PROGRAM_OFFICER_NAME: LIN, SARA

PROJECT_TERMS: 3-Dimensional;Ablation;Adverse effects;Alternative Splicing;Alveolar;Atomic Force Microscopy;Basement membrane;Biomechanics;Cell Communication;Cell Lineage;Cells;Couples;Cues;Cytoplasm;Cytoplasmic Tail;Data;differential expression;Ectopic Expression;epithelial stem cell;ethylene glycol;Extracellular Matrix;Fibroblasts;fibrotic lung;fibrotic lung disease;Fluorescent in Situ Hybridization;Functional disorder;Genetic;Goals;Homeostasis;Human;Hydrogels;idiopathic pulmonary fibrosis;Impairment;Injury;injury and repair;Integrin alpha6;Integrins;Intervention;Invaded;Label;Lung;lung injury;lung repair;Mechanics;Mediating;Mesenchymal;Mesenchyme;Microscopy;Molecular;mRNA Precursor;Mus;Natural regeneration;novel therapeutic intervention;Organoids;Pathologic;Platelet-Derived Growth Factor alpha Receptor;prevent;Property;Protein Isoforms;Pulmonary Fibrosis;pulmonary function;repaired;RNA;RNA Splicing;stem cell niche;stem cell self renewal;stem cells;Structure;Supporting Cell;System;Testing;Therapeutic;Tissues;Transcript;Variant;Work

PROJECT_TITLE: Mechano-niche in Lung Repair after Injury

STUDY_SECTION: LIRR

STUDY_SECTION_NAME: Lung Injury, Repair, and Remodeling Study Section[LIRR]


NIH_SPENDING_CATS: Drug Abuse (NIDA only);Substance Misuse

ORG_CITY: CINCINNATI

ORG_NAME: UNIVERSITY OF CINCINNATI

ORG_STATE: OH

PI_NAMEs: WINHUSEN, T JOHN (contact)

PROGRAM_OFFICER_NAME: DOBBINS, RONALD