ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Behavioral and Social Science;HIV/AIDS;Infectious Diseases;Pediatric;Pediatric - AIDS;Prevention

ORG_CITY: NAIROBI

ORG_COUNTRY: KENYA

ORG_FIPS: KE

ORG_NAME: UNIVERSITY OF NAIROBI

PHR: PROJECT NARRATIVE The proposed program, “Research Training on HIV Prevention and Treatment in Children and Adolescents,” will build research capacity in Kenya for emerging health professionals with clinical backgrounds who wish to continue in clinical practice as well as build a research career in academic settings. The University of Nairobi (UoN) will collaborate with the University of Washington (UW), providing training to improve capacity in epidemiology and biostatistics, towards a goal of strengthening evidence-based approaches to prevent and treat pediatric and adolescent HIV and conduct locally relevant research in Kenya.

PI_NAMEs: FARQUHAR, CAREY ;NDUATI, RUTH WANJIRU;WAMALWA, DALTON CHEKOKO (contact)

PROGRAM_OFFICER_NAME: BANSAL, GEETHA PARTHASARATHY

PROJECT_TERMS: Address;Adolescent;Advisory Committees;Agriculture;AIDS prevention;Biometry;career;career development;Child;Clinical;clinical practice;Collaborations;dalton;Educational process of instructing;Educational Status;Educational workshop;Ensure;Epidemic;Epidemiology;evidence base;experience;Faculty;Female Adolescents;Goals;HIV;HIV Infections;HIV-infected adolescents;Individual;Infant;Institution;interest;Kenya;member;Nurses;Pattern;pediatric human immunodeficiency virus;Persons;Pharmacists;Play;Population;prevent;Principal Investigator;programs;Research;Research Personnel;Research Training;response;Role;scale up;Scientist;success;Technology;Training;training opportunity;Training Programs;transmission process;Universities;Washington;Work;young woman

PROJECT_TITLE: Research Training on HIV Prevention and Treatment in Children and Adolescents (UO

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 DCAI-S (55)]


ADMINISTERING_IC: VA

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: Veterans Affairs

ORG_CITY: CINCINNATI

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: CINCINNATI VA MEDICAL CENTER RESEARCH

ORG_STATE: OH

PHR: The VA Health Care System has done a magnificent, under-appreciated job in the COVID-19 pandemic. The US Veterans served by the health care system are enriched for older men with co-morbid conditions who are especially vulnerable for serious morbidity and mortality from COVID-19 infection. The problems with serious lung injury in SARS infections are mediated by specific antibodies, which are enabling a destructive inflammatory response that makes normal breathing impossible and brings death by suffocation. Antibodies are proteins that our body makes to defend us against infectious organisms. In this situation some of the antibodies appear to have the potential to make the infection more deadly instead of defending the infected Veteran. We propose to identify these specific and dangerous antibodies and then work to understand their structural characteristics and behavior of these so that we can change the clinical outcome for our many Veterans at risk of contracting this deadly infection.

PI_NAMEs: KAUFMAN, KENNETH M (contact)

PROJECT_TERMS: 2019-nCoV;Amino Acids;Antibodies;Antibody Response;Antibody Specificity;Antigenic Specificity;Antigens;Asphyxia;B-Lymphocyte Epitopes;Behavior;Binding;Biological Assay;biosafety level 3 facility;Breathing;Cessation of life;Characteristics;Clinical;comorbidity;Contracts;Coronavirus;COVID-19;COVID-19 mortality;COVID-19 pandemic;current pandemic;Dangerousness;Development;Diagnostic tests;Disease;disease model;Disease Outcome;Donor Selection;Enzyme-Linked Immunosorbent Assay;Epidemiology;Epitope spreading;Epitopes;experience;experimental study;Formulation;Functional disorder;glycosylation;Healthcare Systems;Human;Human Herpesvirus 4;Immune response;Individual;Infection;Infectious Agent;Inflammatory Response;Knowledge;Ku70 protein;Learning;Libraries;Lung Diseases;lung injury;Lupus;Maps;Mediating;Middle East Respiratory Syndrome;military veteran;Minor;Morbidity - disease rate;mortality;Occupations;older men;Outcome;Passive Immunotherapy;Pathogenicity;Patient Care;Patients;Peptides;Persons;Phage Display;Phase;Plasma;Polyethylenes;Population;prevent;Property;Proteins;Public Health;Reagent;Recombinant Proteins;Research Personnel;Resolution;Risk;SARS coronavirus;SARS-CoV-2 antibody;SARS-CoV-2 antigen;SARS-CoV-2 infection;Scourge;Serum;Severe Acute Respiratory Syndrome;Severities;Severity of illness;Solid;Source;Specificity;Structure;Techniques;Testing;theories;Therapeutic;therapy design;Time;Vaccination;Vaccine Design;vaccine response;Veterans;Virus;Western Blotting;Work

PROJECT_TITLE: COVID19: Anti-SARS-CoV-2 Antibodies and Infection Severity


FUNDING_MECHANISM: OTHERS

ORG_CITY: Aurora

ORG_NAME: VA EASTERN COLORADO HEALTH CARE SYSTEM

ORG_STATE: CO

PHR: Chronic Kidney Disease (CKD) is major burden to global health systems and responsible for a disproportionate amount of patient morbidity, mortality, and strain within the Veterans Health Administration. Increasing knowledge of the basic biology of CKD holds the promise to unlock new therapies to halt or reverse kidney fibrosis, a pathologic finding that is responsible for CKD progression in humans. Our proposal seeks to better define the role of eicosanoids, which are potent inflammatory molecules that appear to play a major role in driving chronic inflammation that is directly linked to kidney fibrosis and CKD progression. We plan to use animal models of CKD, genetically altered mice, drug therapies, advanced imaging technology, and other highly sophisticated tools in order to determine how we can exploit certain eicosanoid targets for future drug therapy development in humans.

PI_NAMEs: MONTFORD, JOHN ROSS (contact)

PROJECT_TERMS: Acids;Acute;Acute Renal Failure with Renal Papillary Necrosis;Allergic Reaction;Animal Model;Animals;Anti-Inflammatory Agents;Arachidonate 15-Lipoxygenase;Atherosclerosis;Autacoids;Autoimmune Diseases;Automobile Driving;Back;Biology;Bone Marrow;Bone Marrow Involvement;Bone Marrow Transplantation;Cell Culture Techniques;Cell Differentiation process;cell injury;Cell Separation;cell type;Cells;Chemical Agents;Chronic;Chronic Kidney Failure;Collection;cytokine;Data;Diabetes Mellitus;Dinoprostone;Disease;Disease Progression;Eicosanoids;Enzymes;Epithelial Cells;epithelial injury;Equilibrium;experimental study;Fibrosis;Flow Cytometry;Folic Acid;Future;Gene Expression Profiling;General Population;Genetic;global health;Goals;Health system;Histologic;Human;Hydroxyeicosatetraenoic Acids;Imaging technology;Immune;In Vitro;in vitro Model;in vivo;Infection;Infiltration;Inflammation;Inflammatory;Inflammatory Infiltrate;inhibitor;Injury;Injury to Kidney;interest;Kidney;Kidney Diseases;Kidney Failure;kidney fibrosis;Knock-out;Knowledge;Leukocytes;Light;Link;lipidomics;Lipids;Macrophage;Mediating;Mediator;Microscopic;Microscopy;Microsomes;Modeling;Molecular;monocyte;Morbidity - disease rate;mortality;Mus;Natural regeneration;novel;novel therapeutic intervention;novel therapeutics;Pathogenesis;Pathologic;Pathway interactions;Patients;pharmacologic;Pharmacotherapy;Phenotype;Phospholipid Metabolism;Play;PPAR gamma;Production;Prostaglandin-Endoperoxide Synthase;Proteinuria;Publishing;receptor;Receptor Signaling;recruit;Regulation;renal damage;renal epithelium;Renal function;Renal Tissue;response;Role;Series;Solid;Sorting;Standardization;Stimulus;Stress;Techniques;Testing;therapy development;tissue injury;tool;Translating;Transplantation;Tubular formation;Ureteral obstruction;Veterans;Veterans Health Administration

PROJECT_TITLE: The Role of Bone Marrow Derived Eicosanoids in Renal Disease Progression

STUDY_SECTION: NEPH

STUDY_SECTION_NAME: Nephrology[NEPH]


ADMINISTERING_IC: AI

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;Complementary and Integrative Health;Immunization;Infectious Diseases;Malaria;Malaria Vaccine;Nutrition;Orphan Drug;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases

ORG_CITY: SEATTLE

ORG_NAME: LUMEN BIOSCIENCE, INC.

ORG_STATE: WA

PHR: NARRATIVE Low‐cost, easily delivered vaccines are urgently needed to combat malaria parasites worldwide. To achieve this goal, Lumen Bioscience and the University of Washington will continue development of a spirulina (Arthrospira)‐based, needle‐free, cold chain‐independent, intranasally‐ and/or orally‐delivered Plasmodium vaccine designed to protect against sporozoite challenge.

PI_NAMEs: KHUONG, NHI  (contact);MURPHY, SEAN C

PROGRAM_OFFICER_NAME: MO, ANNIE X  Y

PROJECT_TERMS: Acceleration;Antibodies;Antibody Response;Antigens;Attenuated;Biological Sciences;Blocking Antibodies;booster vaccine;Capital Financing;Capsid Proteins;circumsporozoite protein;Clinic;clinical development;clinical trial protocol;Clinical Trials;Cloning;Cold Chains;combat;Complex;Consumption;cost;cost effective;Cyanobacterium;Department of Defense;Department of Energy;design;Development;Development Plans;disability;Dose;Dryness;Dyes;Engineering;Epitopes;Falciparum Malaria;Female;first-in-human;Fishes;Food;Formulation;Foundations;Future;Genetic;Genetic Engineering;Goals;Grant;Health Personnel;Hepatitis B Virus;Human;Human Papillomavirus;Immune response;immunogenic;immunogenicity;Immunoglobulin G;improved;Inbred Strains Mice;Infection prevention;inhibiting antibody;Intervention;Intranasal Administration;Invaded;Laboratories;Legal patent;Logistics;Malaria;Malaria Vaccines;male;Medical;Medical Waste;Methodology;Modeling;Morbidity - disease rate;mouse model;Mucous Membrane;Mus;Needles;non-compliance;nonhuman primate;Nutritional;Oral;Oral Administration;Oral Poliovirus Vaccine;oral vaccine;Pain;Parasites;parenteral administration;pathogen;Phase;Plasmodium;Plasmodium falciparum;Plasmodium vaccine;pre-clinical;pre-Investigational New Drug meeting;Process;Production;protein expression;Proteins;Recombinants;Regimen;response;Rodent;Role;Route;Safety;safety assessment;Series;Small Business Technology Transfer Research;Source;Spirulina preparation;Sporozoites;Subunit Vaccines;success;Syringes;System;Technology;Training;Universities;Vaccination;vaccine delivery;Vaccine Design;vaccine evaluation;vaccine platform;vaccine strategy;Vaccines;Viral;Virus-like particle;Washington;Woodchuck Hepatitis B Virus

PROJECT_TITLE: Phase II STTR development of an intranasal/oral Spirulina-based PfCSP malaria vaccine.


ORG_CITY: COLUMBIA

ORG_NAME: HARRY S. TRUMAN MEMORIAL VA HOSPITAL

ORG_STATE: MO

PHR: PROJECT NARRATIVE  The prevalence of type 2 diabetes (T2D) continues to increase in the US, with 26.8 million adults carrying a diagnosis. Importantly, T2D is widespread in the Veteran population, and the VA administration spends $1.5 billion annually in diabetes care. This epidemic of T2D also contributes to the staggering rates of cardiovascular disease and cardiovascular mortality. Lifestyle modifications, including increased physical activity, are recommended as first-line therapy for the management of T2D. Unfortunately, patients with T2D exhibit diminished vascular adaptations to exercise. The proposed project will test the overall hypothesis that degradation of the endothelial glycocalyx, a characteristic feature of T2D, precludes shear stress mechanotransduction and consequent exercise-induced vascular adaptations. As such, we pose that restoration of the endothelial glycocalyx via dietary supplementation of glycocalyx precursors will potentiate vascular adaptations to exercise in Veterans with T2D.

PI_NAMEs: MANRIQUE ACEVEDO, CAMILA MARGARITA  (contact);PADILLA, JAUME

PROJECT_TERMS: Adjuvant;Adult;Arteries;Biochemical;Blood flow;Blood Vessels;Cardiovascular Diseases;Cardiovascular system;Caring;Cause of Death;Characteristics;Charge;Chronic;Clinical Trials;db/db mouse;design;Diabetes Mellitus;diabetic;Diagnosis;Dietary Supplementation;Double-Blind Method;Endothelium;Epidemic;Exercise;exercise training;Exhibits;Exposure to;fucoidan;Glucosamine Sulfate;Glycocalyx;Glycoproteins;hemodynamics;Hyaluronan;Impairment;improved;Individual;Inflammation;Left;Life Style Modification;lifestyle intervention;mechanical force;mechanotransduction;Mediating;Methodology;military veteran;Molecular Weight;Morbidity - disease rate;mortality;mouse model;Mus;Non-Insulin-Dependent Diabetes Mellitus;novel;Patients;permissiveness;Phase;Physical activity;Placebos;Population;Prevalence;prevent;prospective;Proteoglycan;Randomized;randomized placebo controlled trial;Recommendation;Research;restoration;Role;shear stress;Side;Signal Transduction;Stimulus;Structure;Superoxide Dismutase;Supplementation;Testing;Therapeutic;Thick;Veterans

PROJECT_TITLE: Targeting the Endothelial Glycocalyx to Enhance Vascular Function and Exercise-Induced Vascular Adaptations in Type 2 Diabetes


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Conditions Affecting the Embryonic and Fetal Periods;Digestive Diseases;Infectious Diseases;Lung;Maternal Health;Microbiome;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Women's Health Research

ORG_CITY: BIRMINGHAM

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE Cesarean delivery, the most common major surgical procedure in the US, is the strongest risk factor for maternal infection (a top 3 cause of death during childbirth). Adjunctive azithromycin compared to standard antibiotic prophylaxis alone is proven (through our large C/SOAP trial and other studies) to be highly effective in preventing infection after cesarean - with authorities now recommending consideration of its use while calling for more information on long-term health outcomes after exposure at birth. We propose a US multi-center long-term follow- up study of children from the parent C/SOAP trial at age 6-8 years to evaluate childhood respiratory and gastrointestinal health effects after perinatal exposure to adjunctive azithromycin; findings from this study will be used to inform and strengthen national and global health care policy regarding the use of adjunctive azithromycin to reduce maternal infection after cesarean delivery.

PI_NAMEs: SUBRAMANIAM, AKILA  (contact)

PROGRAM_OFFICER_NAME: TAYLOR-ZAPATA, PERDITA

PROJECT_TERMS: 7 year old;Accounting;Adoption;Adverse effects;Affect;Age;aged;American College of Obstetricians and Gynecologists;Amniotic Fluid;Antibiotic Prophylaxis;Antibiotics;antimicrobial;Asthma;atopy;authority;Azithromycin;biobank;Birth;Cause of Death;Cefazolin;Cephalosporins;Cesarean section;Child;Childbirth;Childhood;cohort;Cohort Studies;Cost Savings;Data;Development;Diagnosis;Disease;Dose;dysbiosis;Endometritis;Enrollment;environmental allergy;Eosinophilic Esophagitis;Exposure to;follow-up;Follow-Up Studies;Food;Functional disorder;Funding;Future;gastrointestinal;Gastrointestinal Diseases;gastrointestinal function;global health;Half-Life;Health;Health Care Costs;Health Policy;hospital readmission;Human Milk;Immune;Impairment;Incidence;infant gut microbiome;Infection;Infection prevention;Inferior;Inflammatory;Inflammatory Bowel Diseases;Intervention;Intestines;intrapartum;Longitudinal Studies;Longterm Follow-up;Lung;Maternal Mortality;Measures;Mediating;Methods;microbiome;Morbidity - disease rate;Mothers;nasal swab;neonatal outcome;Newborn Infant;offspring;Operative Surgical Procedures;Oral;Outcome;Parents;Pathway interactions;Perinatal Exposure;Pharmaceutical Preparations;Physicians;Physiological;Placebos;Placenta;placental transfer;Population;prenatal;prevent;Prophylactic treatment;pulmonary function;Pulmonary function tests;Questionnaires;randomized trial;Recommendation;Rectum;Reporting;Research Design;respiratory;respiratory morbidity;Respiratory physiology;Risk;Risk Factors;Rome;Safety;Site;Surgical incisions;Surgical Wound Infection;Time;trial design;Umbilical Cord Blood;Visit;Wheezing;Woman;Wound Infection

PROJECT_TITLE: Childhood Pulmonary and Related Outcomes after Perinatal Exposure to Adjunctive Azithromycin Prophylaxis for Cesarean Delivery (C/SOAP Follow-Up Study)

STUDY_SECTION: IRAP

STUDY_SECTION_NAME: Infectious Diseases, Reproductive Health, Asthma and Pulmonary Conditions Study Section[IRAP]


ORG_CITY: NEW YORK

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: The Programming Long-lasting Immunity to Coronaviruses (PLUTO) program project will identify B cell responses and immune histories that lead to long-lasting antibody responses to coronaviruses to inform the design of vaccines that protect from SARS-CoV-2 variants, as well as pandemic, zoonotic and seasonal coronaviruses. The efficacy of interventions will be demonstrated in pre-immune preclinical models. The assembled multi-disciplinary team of investigators has extensive expertise in virology, immunology, pathogenesis, universal vaccine development and structural biology as well as a well-established track record of successful collaborations.

PI_NAMEs: ELLEBEDY, ALI HASSAN;SIMON, VIVIANA A (contact)

PROGRAM_OFFICER_NAME: GORDON, JENNIFER L

PROJECT_TERMS: 2019-nCoV;Achievement;Address;Affinity;Animal Model;Animals;Anti-viral Agents;Antibodies;Antibody Response;Antigens;B-Lymphocytes;betacoronavirus;betacoronavirus vaccine;Binding;Blood specimen;Bone Marrow;cell motility;Cessation of life;climate change;clinical development;Collaborations;Coronavirus;Coronavirus Infections;Coronavirus spike protein;coronavirus vaccination;COVID-19 pandemic;COVID-19 prevention;COVID-19 vaccine;cross reactivity;design;draining lymph node;efficacy evaluation;efficacy testing;emerging virus;Environment;Epitopes;Exposure to;Ferrets;Funding;Future;future pandemic;Generations;Global Change;Goals;Hamsters;Human;human model;Humoral Immunities;Immune;Immune response;Immunity;Immunology;imprint;Individual;Infection;influenzavirus;Institution;Intervention;Knowledge;lymph nodes;member;Messenger RNA;Methods;Modeling;Molecular;Monoclonal Antibodies;multidisciplinary;Mus;National Institute of Allergy and Infectious Disease;neutralizing antibody;new outbreak;next generation;novel;Nucleosides;pandemic coronavirus;pandemic potential;pandemic preparedness;Pathogenesis;pathogenic virus;Persons;Plasma Cells;Pre-Clinical Model;prevent;programs;Public Health;rational design;Recombinants;Recording of previous events;Research;Research Personnel;Research Project Grants;Resistance;Resources;response;risk mitigation;RNA vaccine;Role;Sarbecovirus;SARS-CoV-2 B.1.617.2;SARS-CoV-2 variant;Scientist;seasonal coronavirus;Solid;Specificity;Specimen;structural biology;Structure;success;synergism;Tissues;Treatment Efficacy;universal coronavirus vaccine;universal influenza vaccine;universal vaccine;Vaccinated;Vaccination;vaccination strategy;vaccine candidate;Vaccine Design;vaccine development;vaccine strategy;Vaccines;Variant;Viral;virology;World Health;zoonotic coronavirus


ORG_CITY: BOSTON

ORG_NAME: VA BOSTON HEALTH CARE SYSTEM

ORG_STATE: MA

PHR: The opioid epidemic is a serious public health crisis, with an alarming increase in the rates of opioid use disorder (OUD) and overdose in both the Veteran and general population in the United States over the past two decades. The COVID-19 pandemic is likely to have a short- and long-term impact on the opioid epidemic. It is important to be able to reliably predict which individuals might be more susceptible to developing an OUD or overdose to improve intervention and treatment of high-risk individuals. Post-9/11 Veterans, who were deployed to Iraq, Afghanistan, and other regions in this era of conflicts, have unique risk factors that may predispose them to OUD and overdose related to their history of repeated deployments and deployment- related trauma, including posttraumatic stress disorder, traumatic brain injury and depression. This study will use VA electronic medical record data to build Veteran-specific risk models to understand how the combination of these conditions along with other known and novel risk factors can increase the risk of OUD and overdose.

PI_NAMEs: FONDA, JENNIFER R (contact)

PROJECT_TERMS: addiction;advanced analytics;Adverse event;Afghanistan;aged;Amalgam;Anxiety;Area Under Curve;Behavioral;Biological;blast exposure;career;Caring;chronic pain;classification algorithm;classification trees;cohort;Complex;Computerized Medical Record;COVID-19 pandemic;COVID-19 pandemic effects;Data;Data Science;Databases;Development;Disease;disorder risk;Distal;Domestic Violence;Early Intervention;Epidemiology;epidemiology study;Ethnic Origin;Event;Funding;Gender;General Population;Generations;Goals;gradient boosting;health data;Health Services Accessibility;High Prevalence;high risk;high risk population;improved;Individual;Intervention;Iraq;Lead;long term COVID-19 pandemic impacts;Machine Learning;machine learning algorithm;machine learning classification;machine learning method;machine learning prediction;Measures;Mediating;Mental Depression;Mental disorders;Mental Health;military veteran;Modeling;novel;Opioid;opioid epidemic;opioid misuse;opioid use disorder;Outcome;Overdose;overdose risk;pandemic disease;Performance;Population;post 9/11;Post-Traumatic Stress Disorders;precision medicine;predictive modeling;Predisposition;programs;psychiatric comorbidity;psychologic;Public Health;Race;random forest;Recording of previous events;Recurrence;regression trees;Research;Research Design;Research Methodology;Research Personnel;Risk;Risk Assessment;Risk Factors;Sampling;Sensitivity and Specificity;Social Distance;sociodemographics;study population;Subgroup;Substance Use Disorder;suicidal behavior;Symptoms;targeted treatment;Techniques;Testing;Training;Trauma;trauma exposure;Traumatic Brain Injury;United States;United States Department of Veterans Affairs;Veterans;Veterans Health Administration;Work

PROJECT_TITLE: Predictor Profiles of Opioid Use Disorders and Overdose Among Post-9/11 Veterans


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Coronaviruses;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Infectious Diseases;Prevention;Vaccine Related

PI_NAMEs: SIMON, VIVIANA A (contact)

PROJECT_TERMS: Achievement;Animal Model;Antibodies;B-Lymphocytes;betacoronavirus vaccine;Collaborations;Communication;conflict resolution;Coronavirus;Coronavirus Infections;Coronavirus spike protein;coronavirus vaccination;cost;COVID-19 pandemic;cross reactivity;dashboard;Data;data access;data harmonization;data management;data quality;Databases;Decision Making;design;efficacy evaluation;efficacy testing;Ensure;Environment;Evaluation;experimental study;flexibility;future pandemic;Goals;human model;Humoral Immunities;Immune;Immune response;Immunity;Immunologist;imprint;Infection;Infrastructure;Institution;Interdisciplinary Study;Laboratories;Leadership;Manuscripts;material transfer agreement;medical schools;meetings;Monitor;Monoclonal Antibodies;multidisciplinary;National Institute of Allergy and Infectious Disease;Occupational activity of managing finances;Office of Administrative Management;pandemic coronavirus;Pennsylvania;Performance;Philadelphia;Physicians;Policies;Pre-Clinical Model;Preparation;Principal Investigator;Procedures;programs;Progress Reports;Public Health;quality assurance;Reagent;Recombinants;Recording of previous events;Reporting;Research;Research Institute;Research Personnel;Research Project Grants;Resource Allocation;Resource Sharing;Resources;response;risk mitigation;Sampling;Sarbecovirus;Scientist;seasonal coronavirus;Services;social media;Specificity;Strategic Planning;Structural Biologist;symposium;synergism;Transfer Agreement;United States National Institutes of Health;Universities;Vaccination;vaccine candidate;vaccine development;Vaccines;Variant;Viral;ward;Washington;web page;zoonotic coronavirus

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Coronaviruses;Coronaviruses Therapeutics and Interventions;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Infectious Diseases;Prevention;Vaccine Related

PI_NAMEs: ELLEBEDY, ALI HASSAN (contact)

PROJECT_TERMS: 2019-nCoV;Acceleration;Achievement;Activities of Daily Living;Animal Model;Antibodies;Antigens;B-Lymphocytes;Bacillus anthracis;betacoronavirus;betacoronavirus vaccine;Binding;Blood;Bone Marrow;Cell Separation;Chronic;Circulation;Clinical;Clinical Trials;Clostridium difficile;cohort;Collaborations;Coronavirus;Coronavirus Infections;Coronavirus spike protein;coronavirus vaccination;coronavirus vaccine;COVID-19;COVID-19 pandemic;COVID-19 therapeutics;cross reactivity;design;Development;Diagnostic tests;Dose;efficacy evaluation;efficacy testing;Enterotoxins;Environment;Epitope Mapping;Epitopes;FDA approved;flexibility;future pandemic;Generations;Goals;Human;human coronavirus;human disease;human model;human monoclonal antibodies;Humoral Immunities;Immune;Immune response;Immunity;Immunize;Immunologics;imprint;improved;Infection;Inflammatory;insight;Institution;Knowledge;Life;lymph nodes;Malignant Neoplasms;Maps;Metabolic Diseases;Methodology;Middle East Respiratory Syndrome Coronavirus;Moderna COVID-19 vaccine;Monoclonal Antibodies;multidisciplinary;murine monoclonal antibody;Mus;natural antibodies;Neurons;neutralizing antibody;novel;Nucleosides;pathogenic microbe;Peripheral Blood Mononuclear Cell;Pfizer-BioNTech COVID-19 vaccine;Pharmaceutical Preparations;Pre-Clinical Model;Productivity;programs;Proteins;Public Health;Publishing;Recombinants;Recording of previous events;Research;Research Project Grants;Resources;Respiratory syncytial virus;response;risk mitigation;RNA vaccination;RNA vaccine;Sarbecovirus;SARS coronavirus;SARS-CoV-2 antibody;SARS-CoV-2 spike protein;SARS-CoV-2 variant;Scientist;Screening procedure;single cell technology;single-cell RNA sequencing;Specificity;Specimen;Structure;synergism;Technology;technology platform;Therapeutic;Time;United States;Universities;Vaccination;vaccine candidate;Vaccine Design;vaccine development;Vaccinee;Vaccines;Variant;variants of concern;Viral;Virus;ward;Washington;Work

PROJECT_TITLE: Antibody Core


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Coronaviruses;Coronaviruses Therapeutics and Interventions;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Immunotherapy;Infectious Diseases;Prevention;Vaccine Related

PI_NAMEs: TOMPKINS, STEPHEN MARK (contact)

PROJECT_TERMS: 2019-nCoV;animal coronavirus;Animal Experimentation;Animal Model;animal resource;Animals;Antibodies;Antibody Therapy;B-Lymphocytes;betacoronavirus;betacoronavirus vaccine;Biological Assay;Cattle;college;Communities;Coronavirus;coronavirus disease;Coronavirus Infections;coronavirus vaccination;coronavirus vaccine;Data;Disease;Doctor of Philosophy;effectiveness evaluation;efficacy evaluation;efficacy study;experience;Ferrets;Goals;Hamsters;Health;high risk;Housing;Human;human disease;Immune;Immunity;immunological diversity;Immunological Models;imprint;improved;Individual;Infection;innovation;lead candidate;meetings;Merbecovirus;Middle East Respiratory Syndrome Coronavirus;Modeling;Monoclonal Antibodies;Mus;National Institute of Allergy and Infectious Disease;neutralizing monoclonal antibodies;novel;novel coronavirus;Outcome;pathogen;Pliability;pre-clinical assessment;prevent;Productivity;programs;Protocols documentation;Research;Research Personnel;Research Project Grants;Resources;Respiratory Tract Infections;respiratory virus;response;RNA vaccination;Running;Sampling;Sarbecovirus;SARS coronavirus;SARS-CoV-2 variant;seasonal coronavirus;Serum;Services;success;synergism;Testing;Therapeutic antibodies;therapeutic candidate;Therapeutic Monoclonal Antibodies;tool;training opportunity;Transgenic Mice;transmission process;universal coronavirus vaccine;Universities;Vaccination;vaccine candidate;vaccine development;vaccine efficacy;Vaccine Therapy;vaccine-induced antibodies;Vaccines;Variant;Veterinary Medicine;Viral;Virus;virus resource;Work

PROJECT_TITLE: Animal Core


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Coronaviruses;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Infectious Diseases;Prevention;Vaccine Related

PROJECT_TERMS: 2019-nCoV;Achievement;Activities of Daily Living;Address;Affect;Affinity;Anatomy;Animal Model;Antibodies;Antibody Response;Antibody Specificity;B-Lymphocytes;betacoronavirus vaccine;Blood;Bone Marrow;Cell Separation;Cells;Clinical;Clone Cells;cohort;Collaborations;Complex;Coronavirus;Coronavirus Infections;Coronavirus spike protein;coronavirus vaccination;coronavirus vaccine;COVID-19 pandemic;COVID-19 vaccination;COVID-19 vaccine;cross reactivity;Data;design;Development;draining lymph node;efficacy evaluation;efficacy testing;Environment;Epitope Mapping;Event;experience;Exposure to;flexibility;Funding;Future;future pandemic;Goals;Human;human model;Humoral Immunities;Immune;Immune response;Immune system;Immunity;Immunization;immunogenic;imprint;improved;Individual;Infection;innovation;Institution;Institutional Review Boards;Knowledge;Licensing;Longevity;lymphoid organ;Memory B-Lymphocyte;Microanatomy;Monoclonal Antibodies;multidisciplinary;Mus;New York City;novel;pandemic coronavirus;pandemic disease;pandemic potential;participant enrollment;Peripheral Blood Mononuclear Cell;Plasma Cells;polyclonal antibody;Pre-Clinical Model;programs;Public Health;Recombinants;Recording of previous events;Research;Research Project Grants;Resolution;Resources;respiratory pathogen;response;risk mitigation;RNA vaccination;RNA vaccine;Sarbecovirus;SARS-CoV-2 B.1.1.529;SARS-CoV-2 B.1.351;SARS-CoV-2 B.1.617.2;SARS-CoV-2 infection;SARS-CoV-2 variant;Scientist;seasonal coronavirus;Series;Serology;Specificity;Specimen;Structure;Structure of germinal center of lymph node;Surface;synergism;universal coronavirus vaccine;Vaccination;vaccine candidate;Vaccine Design;vaccine trial;Vaccinee;Vaccines;Variant;variants of concern;Viral;ward

PROJECT_TITLE: Understanding antibody responses and defining correlates of protection for endemic and pandemic coronavirus strains


PI_NAMEs: KRAMMER, FLORIAN  (contact)

PROJECT_TERMS: 2019-nCoV;Achievement;Administrative Coordination;Animal Model;Animals;Antibodies;Antibody Response;Antigens;B-Lymphocytes;betacoronavirus;betacoronavirus vaccine;Binding;Clinical;cohort;Collaborations;Coronavirus;Coronavirus Infections;Coronavirus spike protein;coronavirus vaccination;COVID-19 pandemic;COVID-19 vaccine;Cross Reactions;cross reactivity;design;Development;Disease;Disease Outbreaks;efficacy evaluation;efficacy testing;emerging virus;Environment;Epidemic;Epitopes;experience;Ferrets;Funding;Future;future pandemic;Goals;Human;human model;Humoral Immunities;Immune;Immune response;Immunity;imprint;Infection;Institution;Knowledge;Learning;member;Messenger RNA;Methodology;Middle East Respiratory Syndrome Coronavirus;Modeling;Monoclonal Antibodies;multidisciplinary;National Institute of Allergy and Infectious Disease;neutralizing monoclonal antibodies;novel;pandemic disease;pandemic potential;Pathogenicity;Phenotype;Population;programs;Proteins;Public Health;rational design;Readiness;receptor binding;Recombinants;Recording of previous events;Regimen;Research;Research Project Grants;Resources;response;risk mitigation;Role;Sarbecovirus;sarbecovirus vaccine;SARS coronavirus;SARS-CoV-2 B.1.1.529;SARS-CoV-2 B.1.351;SARS-CoV-2 B.1.617.2;SARS-CoV-2 infection;SARS-CoV-2 spike protein;SARS-CoV-2 variant;Scientist;seasonal coronavirus;Services;Specificity;spillover event;Structure;synergism;Testing;Time;universal coronavirus vaccine;universal influenza vaccine;Update;Vaccination;vaccination strategy;vaccine candidate;Vaccine Design;vaccine development;vaccine effectiveness;vaccine-induced immunity;Vaccines;Variant;Viral;Virus;Work;Zoonoses

PROJECT_TITLE: Development of a pan-betacoronavirus vaccine


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: CLEVELAND

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

PHR: Penicillin-binding proteins (PBPs) are a proven drug target, yet resistance to β-lactam antibiotics, such as carbapenems and cephalosporins, has resulted in a global health problem. We aim to overcome the resistance mechanisms often associated with β-lactam antibiotics, such as β-lactamases, by developing non-β-lactam pyrazolidinone PBP inhibitors to develop novel antibiotics against four ESKAPE pathogens, including Pseudomonas aeruginosa and Acinetobacter baumannii.

PI_NAMEs: VAN DEN AKKER, FOCCO  (contact)

PROGRAM_OFFICER_NAME: XU, ZUOYU

PROJECT_TERMS: Acceleration;Acinetobacter baumannii;Affinity;Amines;analog;Anti-Bacterial Agents;Antibiotic Resistance;Antibiotics;Antimicrobial Resistance;Autolysis;Aztreonam;Bacteria;Bacterial Antibiotic Resistance;Bacterial Counts;beta-Lactam Resistance;beta-Lactamase;beta-Lactams;Binding;Biological Testing;Biophysics;Bypass;carbapenem resistance;Carbapenems;Ceftazidime;Cell Death;Cell division;Cell Wall;Cephalosporins;Chemicals;Colony-forming units;combat;crosslink;Crystallography;design;Development;Dose;Drug Kinetics;Drug Targeting;efflux pump;Electrons;Enzymes;Escherichia coli;ESKAPE pathogens;flexibility;genome sequencing;global health;Goals;Gram-Negative Bacteria;high reward;high risk;Horizontal Gene Transfer;Hydrophobic Interactions;Hydrophobicity;hydroxyl group;Hydroxyl Radical;improved;Individual;Infection;inhibitor;Iron;Iron Chelating Agents;Iron Chelation;Klebsiella pneumoniae;Lactams;Length;Measures;Mechanics;Mediating;Membrane;Meropenem;Modeling;molecular dynamics;Multi-Drug Resistance;Mus;Mutation;novel;novel therapeutic intervention;Penicillin-Binding Proteins;Peptidoglycan;Periodicity;Predisposition;Property;Proteins;Pseudomonas aeruginosa;Reporting;Resistance;resistance gene;resistance mechanism;resistance mutation;resistant Klebsiella pneumoniae;resistant strain;Shapes;Side;Siderophores;Site-Directed Mutagenesis;Structure;Tazobactam;Testing;Thigh structure;trend;uptake;VDAC1 gene;whole genome

PROJECT_TITLE: Developing novel pyrazolidinone antibiotics targeting PBP3 to overcome resistance mechanisms

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DDR-C(01)]


ORG_CITY: PALO ALTO

ORG_NAME: VETERANS ADMIN PALO ALTO HEALTH CARE SYS

ORG_STATE: CA

PHR: Women are a growing share of the VA population, especially among younger veterans. While there have been some limited evaluations of maternal health/pregnancy care and outcomes among women veterans, to date there hasn’t been a comprehensive assessment of this care. The VA provision of this care is complicated by the fact that VA purchases virtually all pregnancy-related care, which effects the coordination of care in both directions (VA sending information to obstetrics providers and receiving back information about the pregnancy). VA has made significant efforts to address care coordination for pregnant veterans. A comprehensive assessment is needed to inform VA of possible gaps and guide continued improvement of this care, especially around factors that veterans are at elevated risk for, such as post-traumatic stress disorder (PTSD). The study team is closely linked with Women’s Health Services (WHS) and will feed results to WHS to allow rapid diffusion of policy relevant findings.

PI_NAMEs: PHIBBS, CIARAN S. (contact)

PROJECT_TERMS: Address;Admission activity;Affect;Age;Age Distribution;Area;Back;Birth;California;care coordination;Caring;Cesarean section;Characteristics;Communities;Complication;Data;Diffusion;Discipline of obstetrics;Disparity;Enrollment;Equity;Ethnic Origin;Evaluation;experience;Feedback;General Population;Geography;Growth;Health;health disparity;Healthcare;high risk;High-Risk Pregnancy;Hospitals;improved;Individual;Infant;infant outcome;innovation;International;Learning;Life;Link;Literature;Maternal Age;Maternal complication;Maternal Health;Maternal Mortality;maternal outcome;maternal risk;Medicaid;Mental Health;Mental Health Services;Methodology;Methods;Military Personnel;mortality;Neonatal;Neonatal Mortality;neonatal outcome;Newborn Infant;Outcome;Patients;Perinatal Care;Policies;Population;Population Heterogeneity;Positioning Attribute;Post-Traumatic Stress Disorders;Postpartum Period;Pre-Eclampsia;Pregnancy;Pregnancy Complications;Pregnancy Outcome;pregnant;premature;Premature Birth;Prenatal care;Process;Provider;Quality Indicator;Race;racial disparity;racial diversity;rapid growth;Records;Regression Analysis;reproductive;Reproductive Health;Research;Research Priority;Risk;Risk Factors;Rural;rural disparities;rurality;severe maternal morbidity;Techniques;Time;Time trend;Translating;Translations;trend;urban disparity;Veterans;virtual;Woman;Women's Health Services;women's outcomes;Work

PROJECT_TITLE: A comprehensive assessment of maternal health and pregnancy outcomes among women veterans

STUDY_SECTION_NAME: HSR-2 Behavioral, Social, and Cultural Determinants of Health and Care[HSR2]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics;Ovarian Cancer;Rare Diseases;Women's Health Research

ORG_CITY: SAINT LOUIS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: WASHINGTON UNIVERSITY

PHR: PROJECT NARRATIVE Hypomorphic mutant BRCA1 proteins support DNA repair and limit the efficacy of PARP inhibitors in a subset of BRCA1 mutant cancer patients. RNF168 is a major driver of BRCA1 localization for the repair of DNA damage, however its role in BRCA1 mutant cancers is not clear. In this proposal, we explore the BRCA1 mutation-specific roles of RNF168 in cancer cell survival, DNA repair, and PARP inhibitor response while also laying the groundwork for future development of RNF168-targeted therapeutics.

PI_NAMEs: KRAIS, JOHN  (contact)

PROGRAM_OFFICER_NAME: JAKOWLEW, SONIA B

PROJECT_TERMS: addiction;Address;Alleles;Automobile Driving;Back;BARD1 gene;Biological;Biological Assay;Biological Models;BRCA1 gene;BRCA1 Mutation;BRCT Domain;C-terminal;Cancer Biology;cancer cell;Cancer cell line;Cancer Patient;cancer risk;cancer therapy;career;Cell Line;Cell Proliferation;Cell Survival;Cells;Clinical;Coiled-Coil Domain;CRISPR/Cas technology;Data;Defect;Dependence;Development;DNA Damage;DNA Double Strand Break;DNA Repair;DNA Repair Gene;drug development;effective therapy;Embryo;Embryonic Development;Exons;Foundations;Funding;Future;Genetic;Goals;Growth;homologous recombination;Immunofluorescence Immunologic;Impairment;inhibitor therapy;insight;Knock-out;Knowledge;Malignant neoplasm of ovary;Malignant Neoplasms;Mediating;Modeling;mouse model;mutant;Mutant Strains Mice;Mutation;N-terminal;Nonhomologous DNA End Joining;PARP inhibition;Pathogenicity;Pathway interactions;patient derived xenograft model;Phenotype;Poly(ADP-ribose) Polymerase Inhibitor;Positioning Attribute;Process;programs;Proteins;recruit;refractory cancer;repaired;Reporter;Research;Research Personnel;Resistance;Resistance development;response;restoration;Role;Secure;Signal Transduction;success;System;targeted treatment;Testing;therapeutic target;Transgenic Mice;Transgenic Organisms;treatment response;treatment strategy;tumor;tumor growth;tumor progression;tumorigenesis;ubiquitin-protein ligase;Work;Xenograft procedure

PROJECT_TITLE: Examining the Role of RNF168 Activity in BRCA1 Mutant Cancers


ORG_CITY: NASHVILLE

ORG_NAME: VETERANS HEALTH ADMINISTRATION

ORG_STATE: TN

PHR: Rheumatoid arthritis (RA) is a chronic disabling inflammatory autoimmune disease which affects nearly 1% of Veterans and increases all-cause mortality more than two-fold. Early and aggressive treatment of RA improves likelihood of remission and reduces disability. Biomarkers identifying patients with high likelihood of developing disease could identify those who would benefit from early interventions aimed at preventing disease and reducing disability. Small RNAs (sRNAs) are novel markers and mediators of disease that have potential for elucidating mechanisms and providing accurate diagnosis and new therapies; thus, this proposal focuses on the role of both human and microbial small RNAs in the development of RA.

PI_NAMEs: ORMSETH, MICHELLE JANE (contact)

PROJECT_TERMS: 2'-Deoxythymidine;accurate diagnosis;Affect;aggressive therapy;antagonist;Autoimmune Diseases;Autoimmunity;Bacteria;Basic Science;Bioinformatics;Biological Assay;Biological Markers;biomarker identification;cell type;Chronic;Clinical;Clinical Data;clinical development;cohort;comparison control;Data;Department of Defense;Development;Diagnosis;disability;Disabling;Disease;Disease Marker;Disease remission;drug response prediction;Early Intervention;Early treatment;Etiology;Feces;First Degree Relative;gene function;Goals;Hepatitis C Therapy;high risk;Human;human disease;Human Genome;human microbiota;immune function;improved;In Vitro;Individual;Inflammatory;innovation;insight;Interferons;Length;Link;machine learning method;Malignant Neoplasms;Maps;Measures;Mediator;member;Membrane;Messenger RNA;metagenomic sequencing;Microbe;microbial;microbial genome;microbiome;microbiome alteration;microbiome specimens;MicroRNAs;mimetics;mortality;next generation sequence data;novel marker;novel therapeutics;Nucleotides;Onset of illness;outcome prediction;Pathway interactions;Patient Care;Patients;Pharmaceutical Preparations;Phase;Plasma;pre-clinical;Prediction of Response to Therapy;prevent;prospective;Regulator Genes;Reporter Genes;repository;Research;response;Rheumatoid Arthritis;Risk;RNA;RNA marker;Role;Sampling;screening;Serology;Serum;Shotguns;Site;Small RNA;Specimen;Structure;Testing;therapeutic RNA;Time;Transfer RNA;Translating;Translations;Untranslated RNA;Validation;Vesicle;Veterans;Virulence Factors

PROJECT_TITLE: Small RNAs and risk of rheumatoid arthritis


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Eye Disease and Disorders of Vision;Lung;Machine Learning and Artificial Intelligence;Neurosciences;Patient Safety

ORG_CITY: BROOKLYN

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: SUNY DOWNSTATE MEDICAL CENTER

PHR: PROJECT NARRATIVE There are 25-32 million perceptual errors in radiological case studies worldwide each year, contributing to med-ical error, the third most common cause of death in the US. We seek to reduce detection errors in radiology with four innovations: (1) we will empirically and objectively determine the visual textures used by expert radiologists to identify abnormalities within medical images; (2) we will determine the ways in which expert radiologists use their eyes, and especially their peripheral vision, to scan images and target informative regions; (3) we will de-velop a perceptual learning paradigm to optimally train residents in both texture perception and oculomotor per-formance domains; and (4) we will construct a deep learning model bestowed with simulated human visual and oculomotor capabilities, to create a normative model of human radiological expertise. The combined results from these studies will quantify peak expert performance and be employed to track and enhance individual expertise acquisition during radiology training; thus, the proposed research will help reduce medical error and moreover provide objective fitness-for-duty measurement tools—based on quantified biomarkers—to evaluate and ame-liorate the effects of fatigue on radiologic performance.

PI_NAMEs: MACKNIK, STEPHEN LOUIS;MARTINEZ-CONDE, SUSANA  (contact);WAITE, STEPHEN

PROGRAM_OFFICER_NAME: MARQUEZ, GUILLERMO

PROJECT_TERMS: Assessment tool;Benchmarking;Biological Markers;Brain;Cancer Detection;cancer diagnosis;cancer imaging;Case Study;Cause of Death;Cessation of life;Characteristics;Clinical/Radiologic;cohort;Collection;Conscious;COVID-19;Data;Data Analyses;Databases;deep learning;deep learning model;design;Detection;Diagnostic;Dimensions;Disease;Elements;Ensure;Entropy;experience;Exposure to;Eye;Eye Movements;Fatigue;Film;fitness;Foundations;Frequencies;heuristics;Human;human error;human model;Image;improved;Incentives;Individual;innovation;Knowledge;Learning;learning network;Location;lung imaging;Measurement;Measures;Medical Errors;Medical Imaging;Medicine;meetings;Modeling;Nature;North America;novel;oculomotor;oculomotor behavior;Outcome;pandemic disease;Participant;Pathway interactions;patient safety;Perception;Perceptual learning;Performance;Peripheral;Positioning Attribute;programs;Radiologic Finding;radiological imaging;radiologist;Radiology Specialty;Reading;Research;Residencies;Resolution;Rest;Retina;sample fixation;Scanning;shift work;skills;Societies;Speed;Sports;statistics;Stress;System;Testing;Texture;Thoracic Radiography;Time;tool;tool development;Training;Unconscious State;Vision;Visual;Workload;X-Ray Computed Tomography

PROJECT_TITLE: Novel Perceptual and Oculomotor Heuristics for Enhancing Radiologic Performance

STUDY_SECTION: CP

STUDY_SECTION_NAME: Cognition and Perception Study Section[CP]


ORG_CITY: BEDFORD

ORG_NAME: EDITH NOURSE  ROGERS MEMORIAL VETERANS HOSPITAL

PHR: Poorly coordinated healthcare increases patient and provider dissatisfaction, health risks, and resource waste. Coordination of specialty care is a particular challenge which is growing as Veterans receive more care from outside VA under the MISSION Act. To optimize specialty care coordination, we must account for the perspectives of Veteran patients. We will use surveys to compare VA primary care patients' experience of coordination for VA specialty care vs. community-based specialty care (CC); examine how clinicians' experience of coordination relates to that of their patients; and examine how patients' experience of coordination in VA and CC relates to test duplication, medication problems, A1C control (in diabetes), self- efficacy, and patient satisfaction. Results will be actionable by VA management, contribute to new scientific knowledge, and form the foundation of future work to better understand and coordinate specialty care, and ultimately improve satisfaction, health, and costs.

PI_NAMEs: VIMALANANDA, VARSHA  (contact)

PROJECT_TERMS: Address;Affect;Agreement;Annual Reports;care coordination;care systems;Caring;Case Management;Case Mixes;Chronic;Chronic Obstructive Pulmonary Disease;Cladribine;Client satisfaction;Clinical;Collaborations;Communities;community based care;Community Care Networks;Community Healthcare;Congestive Heart Failure;Contracts;Coordinated Specialty Care;cost;Data;data exchange;Databases;Diabetes Mellitus;Electronic Health Record;Ensure;evidence based guidelines;experience;Foundations;Funding;Future;Health;health care settings;Healthcare;Homogeneously Staining Region;improved;innovation;Intervention;Knowledge;Measurement;Measures;Medical;medical specialties;Methodology;Methods;Mission;Modeling;novel;Outcome;patient subsets;Patients;Pharmaceutical Preparations;Policies;primary care patient;primary care provider;prospective;Prospective Studies;Provider;provider networks;Quality of Care;Resources;Respondent;Risk;Role;satisfaction;Science;Scientific Advances and Accomplishments;Selection Bias;Self Efficacy;Specialist;stakeholder perspectives;Statutes and Laws;Surveys;System;Testing;Veterans;wasting;Work;Writing

PROJECT_TITLE: Patient Experience of Specialty Care Coordination under the MISSION Act

STUDY_SECTION_NAME: HSR-5 Health Care System Organization and Delivery and Women's Health[HSR5]


ORG_CITY: TAMPA

ORG_NAME: JAMES A. HALEY VA MEDICAL CENTER

ORG_STATE: FL

PHR: The VA system has approved 800,000 disability claims from Veterans which include chronic outcomes of wounds such as increased risk of infections, scars, limited mobility, strained joints and a growing evidence of psychological impact. COVID19 and infection at surgical site, as well as aging, diabetes are significant contributors of slow and delayed wound healing affecting the Veterans’ quality of life. Hence, there is a dire need to develop agents that significantly promote wound closure and support positive long- term outcomes following injury which restore quality of life of US Veterans. Timely treatment also reduces the economic burden. The data shows tremendous potential of hASCexo mediating tissue repair and regeneration for recalcitrant dermal wound related sequelae. Treatment of wounds with hASCexo is an undeniable positive advancement of wound treatment in Veterans. Enhanced treatment of wounds is consistent with the priorities outlined by Department of Veterans Affairs (2018-2024 Strategic plan).

PI_NAMEs: PATEL, NIKETA A. (contact)

PROJECT_TERMS: Acceleration;adipose derived stem cell;Adult;Affect;Aging;Amputation;Biochemical;Biological;Cell Death;Cells;Chemicals;Chronic;chronic wound;Cicatrix;Clinic;comorbidity;Complement;COVID-19;COVID-19 patient;Data;Dermal;Diabetes Mellitus;Economic Burden;Evaluation;exosome;experience;experimental study;Fibroblasts;genome-wide;Genomics;Goals;Harvest;healing;Homeostasis;Human;Impaired wound healing;improved;improved outcome;In Vitro;in vivo;in vivo Model;Infection;infection risk;Inflammation;Inflammatory;Injury;injury recovery;interdisciplinary approach;Intervention;Ischemia;Joints;keratinocyte;knock-down;Laceration;Learning;Lesion;Measures;Mechanics;Mediating;Molecular Target;Natural regeneration;novel;Operative Surgical Procedures;Outcome;overexpression;Pathway interactions;Patients;Pharmacodynamics;Physiological;pre-clinical;Probability;Process;Proliferating;Psychological Impact;Quality of life;Readiness;Recovery of Function;regenerative approach;Regenerative pathway;repaired;Research;Research Design;response;Risk Factors;Rodent;Safety;Severities;Site;Skin;Skin repair;skin wound;Small Interfering RNA;Smoking;stem cell exosomes;Strategic Planning;Structure;Surgical incisions;Surgical Wound Infection;System;Therapeutic;tissue regeneration;tissue repair;Tissues;Topical application;Transcriptional Activation;transcriptome sequencing;Translating;treatment response;United States Department of Veterans Affairs;Untranslated RNA;Veterans;Veterans Disability Claims;wound;wound closure;wound dressing;wound healing;Wound models;wound treatment

PROJECT_TITLE: Cell-free regenerative approach in wound healing


ORG_CITY: BRONX

ORG_NAME: JAMES J PETERS VA  MEDICAL CENTER

PHR: Narrative There is strong sexual dimorphism in the prevalence, symptom presentation and in response to antidepressant treatment in major depressive disorder (MDD). The proposed study will use a recently established female social defeat mouse model to investigate the role of CCL5 and CCR5 in the pathogenesis of depression and to repurpose maraviroc as a novel therapeutic for treating depression. A successful outcome of the application will fill the gap of knowledge in female social stress and provide experimental evidence and supporting data for targeting CCL5/CCR5 axis as novel antidepressant therapy.

PI_NAMEs: WANG, JUN  (contact)

PROJECT_TERMS: Address;Adenylate Cyclase;Adopted;Affect;antagonist;anti-depressive agents;Anxiety Disorders;Astrocytes;Beds;Behavior;biological adaptation to stress;Blood - brain barrier anatomy;blood-brain barrier permeabilization;Brain;Brain region;CCR1 gene;CCR5 gene;cell type;Cells;Central Nervous System;chemokine;Chemotactic Factors;Chronic;Clinical Research;comparison control;cytokine;Data;depression model;Depressive disorder;Disease;Exhibits;Experimental Models;Extravasation;FDA approved;Female;Fluoxetine;Freedom;Functional disorder;Gene Expression Profiling;General Population;Genetic;Glutamates;Health;Human;human female;human subject;Immune;Immunologics;improved;Infiltration;Inflammation;Inflammatory;information gathering;Interleukin-6;Intervention;Investigation;Knowledge;Laboratories;Ligands;Major Depressive Disorder;male;MAP Kinase Gene;Mediating;men;Mental Depression;Mental disorders;Mental health promotion;Microglia;Modeling;Molecular;Monoclonal Antibodies;monocyte;mouse model;Mus;Natural Killer Cells;neurobehavioral test;Neurons;neurovascular;neurovascular injury;novel;novel therapeutics;operation;Oral;Outcome;Pathogenesis;Pathology;Patients;Peripheral;Personal Satisfaction;pharmacologic;Phenotype;PI3K/AKT;Plasma;Play;Population;Post-Traumatic Stress Disorders;Predisposition;Prefrontal Cortex;Prevalence;promote resilience;Protocols documentation;RANTES;receptor;Reporting;resilience;response;Role;seven-transmembrane G-protein-coupled receptor;sex;Sex Differences;sexual dimorphism;Signal Transduction;social defeat;social stress;Stress;stress disorder;stress resilience;Symptoms;Synapses;synaptic function;Synaptic plasticity;T-Lymphocyte;Techniques;Testing;Therapeutic;Therapeutic Agents;transcriptome sequencing;Translating;Translations;Treatment Efficacy;Up-Regulation;Veterans;Woman;women versus men

PROJECT_TITLE: Sex-specific role of CCL5/CCR5 axis in depression and its therapeutic implication


ORG_CITY: WASHINGTON

ORG_NAME: U.S. DEPT/VETS AFFAIRS MEDICAL CENTER

ORG_STATE: DC

PHR: Tobacco use disorder (TUD) remains the leading cause of preventable death in the world. The majority of adult cigarette smokers want to quit and more than half make an attempt but fewer than 1 in 10 smokers successfully quit at the end of 1 year. Rates of cigarette smoking are higher and cessation rates are lower in the veteran population in the United States compared to the nonveteran population. Using noninvasive techniques to change the function of brain areas that are involved in TUD is one approach to developing treatments for TUD. A small area of the brain called the insula is involved in the urge to smoke. This study tests a new noninvasive technique called low intensity focused ultrasound (LIFU) as a way to inhibit the insula and determine whether this causes smokers to have less of an urge to smoke when they see cues that remind them of smoking and whether activity in the insula is decreased after LIFU. Results from this study could provide important information on how the brain becomes addicted to smoking.

PI_NAMEs: LEE, MARY  (contact)

PROJECT_TERMS: addiction;Adult;Affect;Anatomy;Animal Model;Anterior;Area;Behavior;Behavioral;blood oxygen level dependent;Brain;Brain region;cigarette craving;Cigarette Smoker;cigarette smoking;Clinical;Clinical assessments;cost;cranium;craving;Cues;Data;Dorsal;effective therapy;Emotional;experience;Exposure to;Focused Ultrasound;Functional Magnetic Resonance Imaging;Hour;Human;Individual;Insula of Reil;Lateral;Left;Lesion;Link;Magnetic Resonance Imaging;Measures;Methods;military veteran;millimeter;multimodal data;neural;Neurologic;neuroregulation;Neurosurgical Procedures;nicotine craving;Nicotine Dependence;noninvasive brain stimulation;Patient Self-Report;Patients;Pharmaceutical Preparations;Physiological;Population;preventable death;Relapse;Resolution;response;Rest;Role;Safety;safety assessment;Severities;Site;Smoke;Smoker;Smoking;Smoking Behavior;smoking cessation;smoking cue;Somatosensory Cortex;Specificity;Spottings;stem;Stimulus;Structure;Substance Use Disorder;Techniques;Temporal Lobe;Testing;Therapeutic;Tobacco Use Disorder;Transcranial magnetic stimulation;United States;United States Food and Drug Administration

PROJECT_TITLE: Low Intensity Focused Ultrasound for Tobacco Use Disorder:  High Resolution Targeting of the Human Insula


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: CAMBRIDGE

ORG_DEPT: CHEMISTRY

ORG_NAME: HARVARD UNIVERSITY

PHR: Through combination of experimentation and multiscale biophysical modeling this research will provide tools to predict antibiotic escape and other drug resistance dynamics. It will pave the path to develop new approaches to counter drug resistance in evolving pathogens.

PI_NAMEs: SHAKHNOVICH, EUGENE I (contact)

PROGRAM_OFFICER_NAME: NGUYEN, HAN

PROJECT_TERMS: Antibiotic Resistance;Antibiotics;biophysical analysis;biophysical model;biophysical properties;Biophysics;Cell model;Codon Nucleotides;Cytoplasm;Development;Dihydrofolate Reductase;Drug resistance;Enzymes;Escherichia coli;Evolution;experimental study;fighting;fitness;Foundations;genome editing;Genotype;Goals;Immune response;laboratory experiment;Maps;Messenger RNA;Metabolic;metabolomics;Metaphor;model organism;Modeling;Molecular;multi-scale modeling;novel strategies;Nucleic Acids;Outcome;pathogen;Pharmaceutical Preparations;Phenotype;Population;Property;Protein Engineering;protein folding;Proteins;Proteomics;rational design;Reproducibility;Research;Resistance;response;Robotics;Route;Stress;stressor;System;theories;tool;trait;Viral

PROJECT_TITLE: Biophysical foundations of evolutionary dynamics

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-Q(55)R]


ORG_CITY: SAN DIEGO

ORG_NAME: VA SAN DIEGO HEALTHCARE SYSTEM

PHR: Roughly half of all treatment seeking Veterans with PTSD have problems with alcohol, however, the impact of excessive alcohol use on fear extinction and contextual fear processing—processes central to trauma recovery— is unknown. A clear understanding of how ongoing, problematic alcohol use interferes with the mechanisms of fear extinction and contextual fear processing could provide new targets for treatment development and help clinicians and Veterans alike understand how continued problematic drinking may impact exposure-based treatment gains. We propose to use gold-standard and innovative physiological and functional neuroimaging measures to determine the impact of current, heavy alcohol use versus abstinence on the mechanisms of fear extinction and contextual fear processing in Veterans with PTSD and alcoholism. The proposed study will identify critical alcohol-specific mechanisms of impairment to provide a roadmap for the development of targeted interventions to increase efficacy of PAUD treatments.

PI_NAMEs: SPADONI TOWNSEND, ANDREA  (contact)

PROJECT_TERMS: Abstinence;Accounting;Affect;Alcohol abuse;Alcohol consumption;alcohol exposure;alcohol use disorder;Alcoholism;Alcohols;Amygdaloid structure;analog;Anterior;Brain imaging;Chronic;cingulate cortex;Clinical;Clinical Trials;conditioned fear;Coping Skills;Data;design;Development;Discrimination;Disparity population;Dorsal;drinking;Dropout;Environment;expectation;Extinction;Failure;Fright;Functional Magnetic Resonance Imaging;Galvanic Skin Response;Heavy Drinking;Hippocampus;Human;Hyperactivity;Impairment;Individual;innovation;Insula of Reil;Intervention;Investigation;Learning;learning extinction;Link;Maintenance;Measures;Mediating;Molecular;neural;neural circuit;neural correlate;neural network;neural patterning;neuroimaging;neuromechanism;neuroregulation;novel;Outcome;Pattern;pharmacologic;Physiological;Play;Population;Post-Traumatic Stress Disorders;pre-clinical;Pre-Clinical Model;predictive modeling;Prefrontal Cortex;Process;prolonged abstinence;Protocols documentation;Psychophysiology;Recovery;Research;response;Role;Safety;Signal Transduction;Structure;Symptoms;therapy development;Trauma recovery;Veterans;Work

PROJECT_TITLE: Neural correlates of fear conditioning and extinction in veterans with PTSD and alcohol use disorder


ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Project Narrative In this proposal, we will study the role of self stress-peptides in mobilizing an antigen specific CD8 regulatory T cell subtype, restricted to HLA-E, and controlling allo-immunity. We will study in particular, the synthetic FL9 peptides and their role in suppressing T follicular helper cells and donor specific antibody generation. These findings open the possibility of HLA-E-targeted vaccine strategies that exploit the limited polymorphism of this MHC class Ib gene and avoid problems of class Ia MHC diversity.

PI_NAMEs: AZZI, JAMIL  (contact);CANTOR, HARVEY

PROGRAM_OFFICER_NAME: KEHN, PATRICIA J

PROJECT_TERMS: Address;Agonist;Alloantigen;Allografting;Antibodies;Antibody Formation;Antigens;B-Lymphocytes;C-Type Lectins;CD4 Positive T Lymphocytes;CD8 receptor;CD8-Positive T-Lymphocytes;CD8B1 gene;Cells;Chronic;clinical application;Clinical Data;cohort;combinatorial;Complex;Data;donor-specific antibody;Engineering;Generations;Genes;Genetic;Genetic Polymorphism;Graft Rejection;Graft Survival;Heart;heart allograft;Heart Transplantation;Helper-Inducer T-Lymphocyte;Homologous Transplantation;Human;Immune response;improved;Infection;Injury;insight;Isoantibodies;isoimmunity;Kidney;Kidney Transplantation;Knockout Mice;Libraries;Lymphocytic choriomeningitis virus;Major Histocompatibility Complex;Mediating;Membrane Glycoproteins;Modeling;mouse model;Mus;Mutagenesis;Mutation;Natural Killer Cells;NK cell receptor NKB1;novel;novel strategies;Organ Transplantation;Outcome;pathogen;Pathogenicity;Peptide Hydrolases;Peptide Library;Peptides;Positioning Attribute;Production;Proteins;Publishing;Qa-1 Antigen;Reaction;receptor;receptor expression;Regulation;Regulatory T-Lymphocyte;Research;response;Role;selective expression;Signal Transduction;Solid;Specificity;Stress;Study models;Surface;synthetic peptide;T cell response;T-Cell Activation;T-Lymphocyte;Testing;Tissue Grafts;Tissues;transplant model;treatment strategy;vaccine strategy;Variant;Yeasts

PROJECT_TITLE: Peptide-dependent mobilization of CD8 regulatory cells in cardiac transplantation

STUDY_SECTION: TTT

STUDY_SECTION_NAME: Transplantation, Tolerance, and Tumor Immunology Study Section[TTT]


ORG_CITY: IOWA CITY

ORG_NAME: IOWA CITY VA MEDICAL CENTER

ORG_STATE: IA

PHR: Antimicrobial use is one of the strongest risk factors for the emergence of antimicrobial resistance. Antimicrobial stewardship programs (ASPs) can minimize unnecessary antimicrobial use and are thus an essential tool for addressing the crisis of antimicrobial resistance. The VHA has mandated that every VHA hospital have an ASP, but ASPs tend to focus on antimicrobial use administered to patients while hospitalized without addressing antimicrobial use in the 20% of patients who are discharged on an antimicrobial. This proposal will identify hospitals that are having good clinical outcomes while prescribing less antimicrobials to patients both while they are hospitalized and at the time of discharge. The project team will study the processes these high-performing hospitals are using to improve antimicrobial use at discharge. Across all VHA sites, the team will evaluate whether a specific stewardship process at discharge is beneficial.

PI_NAMEs: LIVORSI, DANIEL  (contact)

PROJECT_TERMS: acute care;Address;Admission activity;Adverse drug event;Advisory Committees;antimicrobial;Antimicrobial Resistance;Attitude;Case Mixes;Characteristics;Clinical;Clostridium difficile;Communicable Diseases;Communities;dashboard;Data;Dedications;design;Development;Dose;emerging antimicrobial resistance;evidence base;Feedback;Fostering;Funding;Future;Goals;Health Priorities;Healthcare;Home;Hospital Administration;hospital care;Hospitalization;Hospitals;improved;Infection;Infrastructure;innovation;Inpatients;Intervention;Interview;Knowledge;Length of Stay;Literature;Manuals;Measurement;Methodology;Modeling;Monitor;Outcome;Paper;Patient Admission;Patient Discharge;patient oriented;patient safety;patient subsets;Patients;Perception;Performance;Pharmaceutical Preparations;pilot test;Process;programs;Promoting Action on Research Implementation in Health Services framework;Public Health;Qualitative Methods;Resources;Risk Adjustment;Risk Factors;Safety;Services;Site;Site Visit;Standardization;Structure;Surveys;Targeted Research;Time;tool;Variant;Veterans;Veterans Health Administration;Visit;Work

PROJECT_TITLE: Leveraging inpatient antimicrobial stewardship infrastructure to improve antimicrobial-prescribing at hospital discharge


ORG_CITY: SAN FRANCISCO

ORG_NAME: VETERANS AFFAIRS MED CTR SAN FRANCISCO

PHR: Apnea, the transient cessation of respiration, is one of the most common sleep disorders among U.S. military Veterans. Obstructive sleep apnea (OSA) is characterized by recurrent episodes of partial and complete airway obstruction during sleep with resulting apneas and hypopneas (shallow breathing). The objective of this proposal is to conduct a pragmatic, prospective, observational study that compares a health care delivery model, Direct Referral for Apnea Monitoring (DREAM), with initial in-person (IP) clinic encounters for Veterans at risk for obstructive sleep apnea (OSA). The central hypothesis of the proposed research is that the DREAM clinical pathway can improve Veterans’ access to sleep services by reducing wait times for home sleep apnea testing (HSAT) and OSA treatment while maintaining prognostic accuracy that is comparable to IP assessments. If DREAM demonstrates efficacy in the proposed study, it will facilitate significant improvements in the delivery of VA sleep care services.

PI_NAMEs: SARMIENTO, KATHLEEN FUMIKO;SARMIENTO, KATHLEEN FUMIKO (contact)

PROJECT_TERMS: Adherence;airway obstruction;Apnea;Appointment;Area;arm;Breathing;Cardiovascular Diseases;Cardiovascular system;care providers;care systems;Caring;Cessation of life;Client satisfaction;Clinic;Clinical;Clinical Pathways;comorbidity;Computerized Medical Record;Consultations;Consumption;Continuous Positive Airway Pressure;cost;Data;design;Detection;Diabetes Mellitus;Diagnosis;Diagnostic;Diagnostic tests;diagnostic tool;Disease;Drowsiness;Evaluation;experience;functional outcomes;Gastroenterology;Guidelines;Health;health care availability;Health Care Costs;health care service utilization;Healthcare Systems;high risk;Home;home test;Hypertension;implementation strategy;Improve Access;improved;indexing;Inferior;innovation;Laboratories;Longterm Follow-up;Measures;Medical center;Medicine;Methods;military veteran;Modeling;Monitor;Morbidity - disease rate;mortality;novel;Obesity;Observational Study;Obstructive Sleep Apnea;Outcome;Pathway interactions;Patient Outcomes Assessments;Patient-Focused Outcomes;Patients;Persons;Polysomnography;Population;positive airway pressure;pragmatic study;Predictive Factor;Predictive Value;Predictive Value of Tests;premature;Prevalence;Probability;Procedures;prognostic;programs;prospective;Provider;Publishing;Quality of Care;Questionnaires;Race;Recurrence;Reporting;Research;Resources;Respiration;Risk;Risk Factors;satisfaction;screening guidelines;Service delivery model;Services;Severities;sex;Sleep;Sleep Apnea Syndromes;Sleep Disorders;Sleeplessness;Specialist;Stroke;System;Technology;telehealth;Test Result;Testing;Time;tool;Triage;uptake;Veterans;Wait Time;wireless sensor

PROJECT_TITLE: Improving Access to Sleep Apnea Care: A Pragmatic Study of New Consultation Models


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Dental, Oral, and Craniofacial Disease;Genetics;Infectious Diseases;Nanotechnology;Regenerative Medicine

ORG_CITY: ROCHESTER

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: MicroRNAs are small RNAs that control the formation and loss of bone. For the present application we have conducted experiments showing that microRNAs from the miR 27~23~24 microRNA cluster have great promise as a treatment agent against bone loss. Using this microRNA as an active ingredient in new tissue engineering strategies will help to repair bone and form additional and new bone. We hope that our studies will benefit the health of Americans suffering from bone loss, and result in advanced methodologies for bone regeneration.

PI_NAMEs: LUAN, XIANGHONG  (contact)

PROGRAM_OFFICER_NAME: VERBRIDGE, SCOTT SPENCER

PROJECT_TERMS: Affect;Alkaline Phosphatase;Alveolar;American;angiogenesis;Angiogenesis Inhibitors;Animal Model;Animals;antagonist;BCL2L11 gene;Binding Sites;Biomedical Engineering;blood vessel development;Blood Vessels;bone;bone cell;bone engineering;bone loss;Bone Marrow;Bone Regeneration;Bone remodeling;bone repair;Bone Resorption;Calvaria;Cell Culture Techniques;Cell Proliferation;controlled release;Coupled;Coupling;Craniofacial Abnormalities;craniofacial bone;Data;Defect;Deposition;efficacy evaluation;Endothelial Cells;Engineering;Equilibrium;experimental study;Family;Gene Expression;Genes;Genetic Markers;Growth;Health;Health Benefit;Height;Homeostasis;Implant;implantation;improved;In Vitro;in vitro Model;in vivo;Inflammation;Inflammatory;Laboratories;Mediating;member;Methodology;MicroRNAs;mineralization;Minerals;Molecular;monocyte;nanoparticle;Natural regeneration;Notch Signaling Pathway;novel;novel therapeutics;Oral;osteoclastogenesis;Osteogenesis;osteogenic;overexpression;Periodontal Diseases;Periodontitis;Physiology;progenitor;Reagent;restoration;Role;scaffold;Small RNA;subcutaneous;Testing;therapeutic miRNA;Tissue Engineering;Tissues;tool;Tube;Untranslated Regions;Vascularization

PROJECT_TITLE: New craniofacial bone engineering through miR-23-27-24 cluster mediated osteogenic angiogenic coupling

STUDY_SECTION: MTE

STUDY_SECTION_NAME: Musculoskeletal Tissue Engineering Study Section[MTE]


ADMINISTERING_IC: HL

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Prevention;Primary Health Care;Rural Health;Sleep Research;Social Determinants of Health

ORG_CITY: MORGANTOWN

ORG_NAME: WEST VIRGINIA UNIVERSITY

ORG_STATE: WV

PHR: Rural communities suffer significant healthcare disparities from many common illnesses including respiratory diseases such as obstructive sleep apnea. Obstructive sleep apnea is of particular importance in Appalachia given the high incidence of obesity, cardiovascular and respiratory disease in this population. This research will identify barriers to effective care delivery in obstructive sleep apnea and use the information to better train health care providers in rural communities to more effectively identify and treat the disease.

PI_NAMEs: STANSBURY, ROBERT CALLAWAY (contact)

PROGRAM_OFFICER_NAME: DIXIT, SHILPY

PROJECT_TERMS: acceptability and feasibility;Address;Administrator;Appalachian Region;Appointment;Area;Awareness;barrier to care;Cardiovascular Diseases;care coordination;care delivery;career;career development;Caring;Characteristics;Chronic;Clinical;Clinical Sciences;Clinics and Hospitals;Collaborations;community engaged research;Conduct Clinical Trials;Consolidated Framework for Implementation Research;Critical Care;Data;Data Collection;Diagnosis;Disease;Disease Outcome;Doctor of Medicine;Drowsiness;Education;Educational Intervention;effectiveness/implementation study;Elements;Ensure;evidence base;Faculty;Federally Qualified Health Center;Feedback;Focus Groups;Foundations;Funding;Future;Generations;Goals;Guidelines;Health;health care disparity;health care service organization;health care settings;health disparity;Health Personnel;health training;High Prevalence;implementation evaluation;implementation science;implementation study;improved;Incidence;Injury;interest;Intervention;K-Series Research Career Programs;Knowledge;Lead;Location;Lung;Measures;Medical center;Medicine;member;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Metabolic;Methods;Mood Disorders;multidisciplinary;next generation;novel;Obesity;Obstructive Sleep Apnea;Outcome;Output;Patient-Focused Outcomes;Patients;Physicians;Pilot Projects;Population;Poverty;Preparation;primary care practice;primary care provider;Primary Health Care;primary health center;programs;Protocols documentation;Provider;Pulmonary Heart Disease;Quality of life;Questionnaires;Randomized;randomized effectiveness trial;Research;Research Infrastructure;Research Methodology;Research Personnel;Research Training;Resources;respiratory;Respiratory Disease;respiratory health;Respiratory physiology;Risk;Role;Rural;rural area;Rural Community;Rural Health;rural health clinic;rural health disparities;rural healthcare;Rural Population;rural setting;satisfaction;Scientist;screening;skills;Sleep;Sleep Apnea Syndromes;Sleep disturbances;Social Characteristics;Specialist;suburb;symposium;tertiary care;tool;Training;Translating;Translational Research;Translations;Universities;University Hospitals;West Virginia;Work

PROJECT_TITLE: A Novel Training Intervention to Improve Provider Management of Sleep Apnea in Rural Communities

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(OA)]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Biotechnology

ORG_CITY: ANN ARBOR

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative Chemokines are molecules secreted and sensed by normal cells to control their movements in our body, but chemotaxis also drives multiple diseases, including cancer, atherosclerosis, and neurodegeneration. The project will develop artificial cell-like systems to detect and control local concentrations of chemokines establishing a new technology that may be used in the future to regulate trafficking of cells into or out of a target tissue.

PI_NAMEs: LIU, ALLEN PO-CHIH (contact);LUKER, GARY D

PROGRAM_OFFICER_NAME: MALLIA, CONRAD M

PROJECT_TERMS: Address;Architecture;Atherosclerosis;Binding;Biological Models;Biology;Biomedical Research;Biosensor;CCL21 gene;cell behavior;cell motility;cell type;Cells;cellular engineering;cellular imaging;chemokine;chemokine receptor;Chemotaxis;clinical translation;Complex;Custom;CXCR4 gene;cytokine;design;Development;Disease;Encapsulated;Engineering;Environment;Fibroblasts;Future;G-Protein-Coupled Receptors;Growth Factor;Heterogeneity;Human;Hydrogels;imaging modality;Imaging technology;improved;In Situ;In Vitro;in vivo;innovation;Intervention;Ligands;Lipid Bilayers;Malignant Neoplasms;Mammalian Cell;mammary;Measures;Mediating;Methods;Microfilaments;migration;Molecular;Monitor;Movement;Neoplasm Metastasis;Nerve Degeneration;new technology;Normal Cell;Normal tissue morphology;notch protein;novel;novel therapeutic intervention;Output;Pathologic;Pathway interactions;Peptide Hydrolases;Pharmacologic Substance;Phosphotransferases;Physiological;Physiology;prevent;Proliferating;quantitative imaging;real time monitoring;receptor;Receptor Signaling;reconstitution;recruit;Regenerative Medicine;regenerative therapy;Reporter;Reporting;Research;Research Personnel;response;Signal Transduction;Site;source localization;Specificity;spheroids;Stromal Cell-Derived Factor 1;synthetic biology;System;targeted agent;Testing;Therapeutic;Time;tissue repair;Tissues;tool;tool development;trafficking;Vesicle;Visualization;Work

PROJECT_TITLE: Sensing and modulating the chemokine environment with synthetic cells

STUDY_SECTION: CMT

STUDY_SECTION_NAME: Cellular and Molecular Technologies Study Section[CMT]


ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI VA MEDICAL CENTER RESEARCH

PHR: Rheumatoid Arthritis (RA) is a devastating systemic disease, which without intensive medical attention and often very expensive therapeutics, often results in joint destruction and virtually complete physical incapacity. We have developed new results that suggest Epstein-Barr virus (EBV) may be a possible cause of RA and have shown that this virus can infect cells from the joints and alter the expression of RA genes. We identified a protein from the virus that potentially alters gene expression in ways that encourage the development of RA and propose to explore its actions in cells, which if our suspicions are established, will provide the basis to change how RA is diagnosed, treated, and, perhaps, even prevented.

PI_NAMEs: KAUFMAN, KENNETH M (contact)

PROJECT_TERMS: Alleles;Arthritis;Autoantibodies;Award;B-Lymphocytes;CD8-Positive T-Lymphocytes;Cell Line;Cells;ChIP-seq;Chronic;Complex;cyclic citrullinated peptide;Data;Degenerative polyarthritis;Dependence;design;Development;Diagnosis;differential expression;disorder control;DNA;DNA Binding;Elements;Environment;Epstein-Barr Virus Infections;Epstein-Barr Virus latency;Epstein-Barr Virus Nuclear Antigens;Etiology;experience;experimental study;Fibroblasts;Foundations;Frequencies;Future;Gene Expression;Gene Expression Profile;Gene Expression Regulation;gene product;Genes;Genetic;Genetic Risk;genomic locus;Human;Human Herpesvirus 4;Immune;Immune response;Immunoprecipitation;Individual;infected B cell;Infection;Inflammatory;Inflammatory Response;insight;Investigation;joint destruction;Joints;Learning;Lytic Virus;medical attention;microbiome;Modeling;morphogens;Nature;novel therapeutic intervention;Nuclear Antigens;Pathogenesis;Pathology;Patients;Peptides;Population;prevent;Prevention strategy;Probability;Process;programs;Property;Publications;PubMed;Quantitative Trait Loci;Relative Risks;response;Rheumatoid Arthritis;Risk;risk variant;single-cell RNA sequencing;Site;small molecule libraries;Specificity;Synovial Membrane;Systemic disease;T cell response;Testing;Therapeutic;Tissues;transcription factor;transcriptome sequencing;Variant;Viral;Viral Antigens;viral DNA;Viral Proteins;virtual;Virus;Virus Diseases;Work

PROJECT_TITLE: DNA Binding of Human and Viral Transcription Factors is Associated with Rheumatoid Arthritis Risk Loci

STUDY_SECTION: IMMA

STUDY_SECTION_NAME: Immunology and Dermatology A[IMMA]


PHR: Technology holds the potential to aid in understanding the real-world phenomenology of risk for suicide, including identifying potential targets for early intervention. This project will employ smartphone-delivered tests of specific cognitive variables and examine real-time relationships between cognitive dysfunction, negative emotions and social contexts, and suicide risk in Veterans. This pilot project implements mobile health tools for understanding the cognitive mechanisms underlying suicidal ideation outside of the laboratory, setting the stage for future mechanistic and intervention research.

PI_NAMEs: BOMYEA, JESSICA  (contact)

PROJECT_TERMS: Address;Adopted;Affective;Behavior;Behavioral;behavioral outcome;Belief;Cellular Phone;Classification;Clinical;Cognition;Cognitive;cognitive control;cognitive function;cognitive performance;cognitive process;cognitive rehabilitation;cognitive testing;common symptom;Computerized Medical Record;contextual factors;coping;Coping Skills;Coupling;Data;Data Set;design;Diagnostic;Distal;Distress;Early Intervention;Ecological momentary assessment;emotion regulation;Emotional;Emotions;experience;Feeling suicidal;follow-up;Foundations;Functional disorder;Future;health assessment;Health Technology;high risk;ideation;Impaired cognition;Individual;individual variation;innovation;inpatient psychiatric treatment;Intervention;Intervention Studies;Knowledge;Laboratories;Life;Link;longitudinal dataset;Longitudinal Studies;Measurement;Measures;Medical Records;Mental Depression;Methods;mHealth;Modification;Monitor;Outcome;Participant;Pattern;performance tests;Pharmacotherapy;phenomenological models;physical state;Pilot Projects;Populations at Risk;Predictive Factor;predictive tools;Prevalence;prospective;Prospective Studies;psychiatric symptom;Reporting;Research;Research Priority;response;Risk Factors;Risk Reduction;Role;Sampling;Services;Severities;Sleep;sleep quality;social;social cognition;Social Environment;statistics;Stress;Subgroup;suicidal;suicidal behavior;suicidal risk;Suicide;Suicide prevention;Symptoms;Technology;telehealth;Testing;Theoretical model;Time;tool;United States Department of Veterans Affairs;urgent care;Veterans;Visit;Work

PROJECT_TITLE: Application of a mobile health platform for assessing cognition and psychiatric symptoms in Veterans


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Coronaviruses;Infectious Diseases;Lung;Prevention;Rare Diseases

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Acute respiratory distress syndrome (ARDS) affects 200,000 in the US annually with 40% mortality and no known cure. Mortality attributable to Covid-19 infection often occurs through the development of viral pneumonia-induced ARDS. Lung inflammation leads to increases in lysolipid concentrations that inhibit normal lung surfactant performance, leading to mechanical instabilities causing non-uniform lung inflation, exacerbating the inflammation, possibly leading to ARDS.

PI_NAMEs: ZASADZINSKI, JOSEPH ANTHONY (contact)

PROGRAM_OFFICER_NAME: LIN, SARA

PROJECT_TITLE: Lipid and Protein Effects on Monolayer Stability

STUDY_SECTION: BBM

STUDY_SECTION_NAME: Biochemistry and Biophysics of Membranes Study Section[BBM]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Neurosciences;Radiation Oncology;Rare Diseases

ORG_CITY: BOSTON

PHR: Narrative There is an unmet need for patient-specific, personalized mapping of tumor margins in order to improve clinical treatment of glioblastomas, the most prevalent and deadly primary brain tumor in adults. We propose to investigate and validate novel diffusion-relaxation MRI methods for mapping tumor margins and infiltration. This is expected to provide important information for glioblastoma treatment planning, with the potential of improving patient survival and quality of life.

PI_NAMEs: GOLBY, ALEXANDRA J;WESTIN, CARL-FREDRIK  (contact)

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: Adult;Anisotropy;Area;Biopsy;Brain;Brain imaging;Brain Neoplasms;brain parenchyma;brain tissue;Cell Density;Cell Size;Cells;chemotherapy;Chemotherapy and/or radiation;Clinical;clinical application;clinical imaging;Clinical Treatment;Data;Data Set;design;Diffuse;Diffusion;Diffusion Magnetic Resonance Imaging;digital;Discrimination;Drug Delivery Systems;Excision;Glioblastoma;Glioma;Goals;Histologic;Histology;Histopathology;Human;human subject;Image;imaging modality;Implant;improved;in vivo;Infiltration;Joints;Magnetic Resonance Imaging;Maps;Measures;meetings;Methods;Microscopic;Modeling;Motion;mouse model;Mus;neoplastic cell;neuroimaging;Neurosurgeon;neurosurgery;novel;Operative Surgical Procedures;Outcome Study;Patient Care;patient derived xenograft model;Patients;Phenotype;Physiologic pulse;pre-clinical;Price;Primary Brain Neoplasms;Quality of life;Radiation;Radiation Oncologist;Radiation therapy;Radiology Specialty;Relaxation;Scanning;Shapes;Structure;success;Time;tissue mapping;Tissue Sample;Tissues;Translating;treatment planning;tumor;tumor growth;Tumor Tissue;Uncertainty;Validation;Water;Work

PROJECT_TITLE: Quantitative Glioblastoma Margin and Infiltration Mapping with advanced diffusion-relaxation MRI


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Lung;Lung Cancer;Prevention

ORG_CITY: TALLAHASSEE

ORG_DEPT: PSYCHOLOGY

ORG_NAME: FLORIDA STATE UNIVERSITY

PHR: PROJECT NARRATIVE Behavioral interventions hold promise for the promotion of health and the reduction of healthcare costs. By training 100 investigators from the behavioral and social sciences in the key design questions and range of methodologies that can be used to develop and refine behavioral interventions their early phases of development, we can improve the quality of health behavior trials for cancer prevention and treatment and related health beahviors. Ongoing training, evaluation, and dissemination will promote both innovation and reach and ultimately translation of effective treatments into clinical practice for public health impact.

PI_NAMEs: NAAR, SYLVIE  (contact)

PROGRAM_OFFICER_NAME: RADAEV, SERGEY

PROJECT_TERMS: Acceleration;Address;Adult;aged;Attention;attributable mortality;Basic Behavioral and Social Science Research;Basic Science;Behavior Therapy;Behavioral;behavioral and social science;Behavioral Research;bench to bedside;cancer prevention;Cancer Prevention Trial;cancer therapy;Cardiovascular Diseases;career;Chronic Disease;clinical practice;Clinical Trials Design;Consultations;Control Groups;Course Content;course development;Creativeness;curriculum development;Dedications;design;Development;Diabetes Mellitus;Discipline;Dose;Drops;drug development;Educational Curriculum;Educational process of instructing;Educational workshop;effective therapy;efficacy testing;Ensure;Evaluation;Exposure to;Faculty;follow-up;Goals;Grant;Health;Health behavior;Health Care Costs;Health Promotion;improved;innovation;interest;Intervention;Intervention Studies;investigator training;Knowledge;Learning;lectures;Link;literacy;Malignant Neoplasms;Mentors;Methodology;Methods;Minority;Modeling;modifiable risk;mortality;Participant;Persons;Phase;premature;prevent;Process;programs;Public Health Practice;public health priorities;Publications;Qualitative Evaluations;Quantitative Evaluations;Questionnaires;recruit;Research Personnel;Risk Factors;Sampling;Scientist;sedentary lifestyle;skill acquisition;skills;Smoking;social science research;Specific qualifier value;success;Surveys;Techniques;Technology;therapy design;therapy development;Time;Trainers Training;Training;Translational Research;Translations;treatment optimization;Unhealthy Diet;United States National Institutes of Health;Video Recording;web site;webinar;Work

PROJECT_TITLE: Methods for Early Phase Translation of Basic Science into Behavioral Treatments to Improve Health


ADMINISTERING_IC: MH

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Mental Health

ORG_CITY: NEW YORK

ORG_DEPT: PSYCHIATRY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: People in Low and Middle Income Countries and in low-resource areas of the U.S. do not receive proper mental health care. This Global Mental Health Implementation Science Fellowship will train scientists to enhance access and implementation of effective, feasible, sustainable and scalable mental health interventions that are adapted to the culture and context of each setting, making more efficient use of less specialized human resources available in various systems of care.

PI_NAMEs: WAINBERG, MILTON L (contact)

PROGRAM_OFFICER_NAME: KAMATH, SUSANNAH M A

PROJECT_TITLE: Global Mental Health (GMH) Research Fellowship: Interventions that Make a Difference


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Digestive Diseases;Liver Disease

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: PROJECT NARRATIVE / RELEVANCE TO PUBLIC HEALTH Digestive and liver diseases have a significant impact on public health: according to data curated by NIDDK, 60-70 million Americans suffer from digestive and liver disorders, resulting in substantial direct healthcare costs (estimated at $97.8 billion in 2004). Thus, significant research into disease prevention and treatment for this group of disorders is a major public health priority. This grant will support a training program aimed at preparing the next generation of scientists focused on digestive and liver disorders.

PI_NAMEs: BURSTEIN, EZRA  (contact)

PROGRAM_OFFICER_NAME: SERRANO, KATRINA JANE

PROJECT_TITLE: UT Gastroenterology/Hepatology Research Training Program


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Mental Health;Networking and Information Technology R&D (NITRD);Neurosciences;Opioid Misuse and Addiction;Opioids;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: RICHMOND

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: PROJECT NARRATIVE The computational methods we propose to use in this application have the potential to increase the efficiency and informativeness of neuropsychiatric assessment batteries, while reducing their burden of administration. This may increase the diagnostic and prognostic precision of available neuropsychiatric assessment instruments and facilitate their wider implementation in clinical practice.

PI_NAMEs: AHN, WOO-YOUNG ;VASSILEVA, JASMIN L (contact)

PROGRAM_OFFICER_NAME: MOLLICK, JESSICA ANN

PROJECT_TERMS: addiction;Address;alcohol use disorder;Alcohols;Assessment tool;Attention;Bayesian Modeling;Behavior;Behavioral Model;Behavioral Paradigm;Biological Assay;biomarker discovery;biomarker performance;Brain;Bulgaria;Classification;clinical practice;Cocaine use disorder;Cognition;cognitive function;cognitive process;Computational Science;Computer software;computerized tools;Computing Methodologies;cost;Country;Data;Data Collection;Decision Making;design;Diagnostic;Dimensions;discounting;Disease;disease classification;Effectiveness;Emotional;endophenotype;Etiology;executive function;Feedback;Goals;Heterogeneity;heuristics;Hour;improved;incentive salience;indexing;Individual;Influentials;Infrastructure;Intervention;Knowledge;machine learning algorithm;Measures;Methods;mobile application;Modeling;Monitor;neurobehavioral;Neurobiology;Neurocognitive;neuroimaging;neuropsychiatry;Neurosciences;novel;open source;Opioid;opioid use disorder;Outcome;Participant;Pathway interactions;Patient Self-Report;patient subsets;Patients;Phenotype;Population Heterogeneity;prevent;Procedures;Prognosis;prognostic;rapid test;Research;response;Sampling;Smoking Cessation Intervention;software development;South Korea;Stimulant;Substance Use Disorder;Testing;Time;Tobacco;tobacco smokers;trait;treatment response;undergraduate student;Validation;Veterans;web platform

PROJECT_TITLE: Utility of adaptive design optimization for developing rapid and reliable behavioral paradigms for substance use disorders

STUDY_SECTION: ARM

STUDY_SECTION_NAME: Addiction Risks and Mechanisms Study Section[ARM]


ORG_CITY: CHAPEL HILL

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE We are in the midst of a rapidly moving and dynamic era of biomedical research, where the gap between basic biology and medical practice is growing. The quickening pace of scientific discovery demands a new generation of scientists who are able to understand the languages spoken both in the research setting and in the clinic at the bedside, and communicate effectively with each. The overarching objective of this application is to generate a cadre of translational Ph.D. researchers with the knowledge and skills necessary to appreciate and address clinically-relevant biological problems from the perspective of basic science.

PI_NAMEs: BAE-JUMP, VICTORIA LIN;WEISSMAN, BERNARD E. (contact)

PROGRAM_OFFICER_NAME: JONES, LATAISIA CHERIE

PROJECT_TERMS: Doctor of Philosophy;next generation;Scientist;Training

PROJECT_TITLE: Enhancement training for the next generation of translational Ph.D. scientists

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - A[TWD-A]


ORG_NAME: VA BOSTON HEALTH CARE SYSTEM

PHR: More than 300,000 Veterans have been exposed to blast or concussive injury, a number that grows larger every year. Veterans experience multiple mild traumatic brain injuries (mTBI) through military-related activities, contact sports participation (including American football, hockey, or boxing) and other recreational activities. Veterans exposed to concussive or blast mTBI are at risk for developing the progressive neurodegenerative disease, chronic traumatic encephalopathy or CTE. CTE cannot yet be diagnosed during life and there are no treatments. Very little is known about how CTE is triggered in the brain and how it progresses, although our previous studies suggest that neuroinflammation and neurodegenerative cells play a pivotal role. We propose to comprehensively identify the inflammatory proteins and cell types involved in the onset of CTE. The results generated by this study will lead to new ways to identify CTE in living Veterans, and to develop effective therapies.

PI_NAMEs: CHERRY, JONATHAN D (contact)

PROJECT_TERMS: Advisory Committees;American;Amyloid beta-Protein;Area;Astrocytes;Autopsy;Behavioral;behavioral impairment;Bioinformatics;biomarker identification;Blood Vessels;Boston;Boxing;Brain;brain cell;Brain Concussion;Brain region;brain tissue;career;cell type;Cells;chronic traumatic encephalopathy;Clinical;Cognitive;cohort;Collaborations;Color;Consensus;contact sports;Craniocerebral Trauma;Data;Deposition;design;Development;Diagnosis;differential expression;Disease;Dissection;effective therapy;Endothelial Cells;Environment;experience;Exposure to;Fluorescent in Situ Hybridization;Foundations;Freedom;Freezing;frontal lobe;Genes;Genomics;Goals;Heterogeneity;Hippocampus;Hockey;Hospitals;Human;Human Resources;hyperphosphorylated tau;Immune;Immunohistochemistry;immunoregulation;Individual;Inflammation;Inflammatory;Inflammatory Response;injured;Injury;interest;Jamaica;Knowledge;Laboratory Research;Lesion;Life;Location;Manufactured football;Measures;meetings;Memory;Mentors;Methods;Microglia;mild traumatic brain injury;Military Personnel;military service;military veteran;Motor;Nerve Degeneration;Neuroanatomy;Neurodegenerative Disorders;neurodegenerative phenotype;neuroinflammation;Neuronal Dysfunction;Neurons;neuropathology;novel diagnostics;novel marker;novel therapeutics;Oligodendroglia;operation;Pathogenesis;Pathologic;Pathology;Patients;Phenotype;Play;Population;Postdoctoral Fellow;Process;protein TDP-43;Proteins;Recording of previous events;Recreation;Research;Research Personnel;Resolution;Resources;Risk;Risk Factors;RNA;Role;Senior Scientist;Severities;Severity of illness;Shapes;Single Nucleotide Polymorphism;single nucleus RNA-sequencing;single-cell RNA sequencing;Soldier;Stains;tau aggregation;therapeutically effective;therapy design;Tissues;Training;United States Department of Veterans Affairs;Universities;Veterans;Visualization;Work

PROJECT_TITLE: Identification of the neuroinflammatory signature for CTE using single nucleus RNA sequencing


ORG_CITY: BAY PINES

ORG_NAME: BAY PINES VA MEDICAL CENTER

PHR: Traumatic brain injury (TBI) is a serious public health problem with approximately 69 million individuals estimated to sustain a TBI each year. TBI is a regarded as a signature wound for many Veterans, with the rate of TBI among troops reported to be as high as 33%. Furthermore, the propensity for head injuries sustained in combat has placed our Veterans at even greater risk for developing neurodegenerative disorders such as Alzheimer’s disease (AD), highlighting the urgency to understand the causal factors that can be targeted to prevent or treat affected Veterans. At the moment, there are no effective disease-modifying therapies available for TBI or AD, and there is a clear, unmet need for novel strategies to treat these disorders. The current proposal will investigate a critical biological mechanism that contributes to disease progression following TBI, with the purpose of identifying new treatment strategies for this disorder, which will improve the welfare of our Veteran population.

PI_NAMEs: BACHMEIER, CORBIN  (contact)

PROJECT_TERMS: Acute;Affect;Agonist;Alzheimer's Disease;Animals;Appearance;Atrophic;Automobile Driving;Axon;Behavior;Biological;Blood Vessels;Brain;Brain Injuries;brain pericytes;Cell Count;Cell Differentiation process;Cells;Cerebrum;Chronic;Chronic Phase;Cognitive;combat;Craniocerebral Trauma;Deterioration;Disease;Disease Progression;Encephalitis;extracellular;fluid percussion injury;Functional disorder;Health;Homeostasis;Human;immunoregulation;Impaired cognition;improved;Individual;Inflammation;Inflammatory;Injury;Laminin;Ligands;Mediating;Mediator;mild traumatic brain injury;military veteran;Modeling;mouse model;Mus;Myelin;neurobehavior;Neurodegenerative Disorders;neuroinflammation;neurovascular unit;novel strategies;novel therapeutic intervention;oligodendrocyte progenitor;Oligodendroglia;Pathologic;Pathology;Pathway interactions;Pericytes;Phenotype;Phenytoin;Platelet-Derived Growth Factor;platelet-derived growth factor BB;Platelet-Derived Growth Factor beta Receptor;Population;precursor cell;prevent;Public Health;receptor;remyelination;Reporting;residence;response;Risk;Role;Signal Transduction;Specimen;Stimulus;tau aggregation;tau mutation;tau Proteins;Testing;Thinness;Time;Transgenic Organisms;Traumatic Brain Injury;treatment strategy;uptake;Veterans;welfare;white matter;Work;wound

PROJECT_TITLE: Effect of pericyte stimulation on traumatic brain injury pathophysiology


ORG_CITY: Decatur

ORG_NAME: VETERANS HEALTH ADMINISTRATION

ORG_STATE: GA

PHR: Overall, our proposal is conceptually novel in that it seeks to implicate a membrane transporter in essential pathophysiological functions that are not directly dependent on its transport activities. In addition, the proposed research will also facilitate the development of therapeutic strategies targeting intestinal inflammatory conditions, including colitis and may prevent colitis associated cancer. Impact on Veterans Health care: Over one million adults in the US, including members of the VA population, suffer from IBD, and about 50,000 new cases are diagnosed each year (according to the Crohn’s and Colitis Foundation of America. The VA IBD patients have a much higher rate of colorectal cancer compared to the general population (2.9% vs. 0.1%; from National Center for Health Statistics data). Thus, attaining an understanding of the etiology of IBD and the relevant pathological mechanisms are major aims of research seeking to develop effective future treatments will directly benefit the veteran population.

PI_NAMEs: MERLIN, DIDIER  (contact)

PROJECT_TERMS: Adult;Affect;Alginates;Anti-Inflammatory Agents;Bacteria;Cell Physiology;cell type;Cells;cellular targeting;Colitis;colitis associated cancer;Colon;Colorectal Cancer;Crohn's disease;Data;dextran sulfate sodium induced colitis;Diagnosis;Down-Regulation;Drug Delivery Systems;Engraftment;Epithelial Cells;Etiology;experimental study;fecal transplantation;Foundations;Funding;Future;gain of function;General Population;Genetic;genome-wide;Goals;gut inflammation;Healthcare;Hydrogels;Immune system;in vivo;Inflammation;Inflammatory;intestinal epithelium;intestinal homeostasis;Intestinal permeability;Intestines;Large Intestine;loss of function;Mediating;member;Membrane Transport Proteins;Metabolic;metabolome;microbiota;microbiota transplantation;MicroRNAs;military veteran;Modification;mouse model;Mucosal Immune Responses;Mucous body substance;murine colitis;Mus;nanoparticle;novel;Oligopeptides;Oral;Oral Administration;Oral Examination;Pathologic;Patients;Peptides;Phenotype;Population;Predisposition;prevent;Prevention;Proteomics;Protons;Research;response;Role;Severities;Small Intestines;Testing;therapeutic development;tumorigenesis;United States National Center for Health Statistics;Up-Regulation;Variant;Veterans;Wild Type Mouse

PROJECT_TITLE: PepT1-/- microbiota therapy as a treatment for colitis