NIH_SPENDING_CATS: Bioengineering;Biotechnology;Clinical Research;Contraception/Reproduction;Maternal Health;Nanotechnology;Pediatric;Pregnancy;Women's Health Research

ORG_CITY: Pittsburgh

ORG_NAME: MAGEE-WOMEN'S RES INST AND FOUNDATION

PHR: Our proposal centers on the discovery and analysis of previously unrecognized nanovesicle subpopulations that are produced by placental cells and are released to the maternal-fetal circulation. By studying these nanovesicle subpopulations in health and diseases of human pregnancy and by innovating new technologies to efficiently, rapidly, and reproducibly purify these nanovesicles from the blood and other biological media, we enable pioneering tools to interrogate the placenta in real time and improve clinical care during pregnancy.

PI_NAMEs: HUANG, TONY JUN ;SADOVSKY, YOEL  (contact)

PROGRAM_OFFICER_NAME: WEINBERG, DAVID H

PROJECT_TERMS: Address;Animal Model;Anti-viral Response;Apoptotic;Bathing;bioinformatics tool;Biological;Biological Process;Biology;biomaterial compatibility;Blood;Blood Tests;Blood Vessels;Bulla;Cell Culture Techniques;cell type;Cells;Circulation;Clinical;clinical care;clinically relevant;Communication;Culture Media;Data;data complexity;design;Devices;Diagnostic;differential expression;Dimensions;Discipline of obstetrics;Disease;epigenomics;exosome;extracellular vesicles;fetal;Fetal Development;Fetal Growth;Fetal Growth Retardation;Field Flow Fractionation;first responder;Functional disorder;Funding;Genomics;Glean;Grant;Growth and Development function;Health;Health Status;Homeostasis;Human;human disease;Image;improved;in vivo;Inherited;Injury;innovation;insight;Investigation;Lipoproteins;liquid biopsy;Location;machine learning pipeline;Magnetic Resonance Imaging;Manuscripts;Maternal-Fetal Exchange;Medicine;Metabolic;MicroRNAs;microvesicles;MLLT2 gene;Modification;Molecular;molecular diagnostics;nanosized;nanovesicle;National Institute of Child Health and Human Development;Nature;new technology;noninvasive diagnosis;novel;Pathologic;Pathway interactions;peripheral blood;Physiological;Placenta;Placenta Diseases;Placental Biology;placental trophoblasts;Plasma;Population;Positioning Attribute;Postpartum Period;Pre-Eclampsia;Pregnancy;Pregnancy Complications;pregnancy health;Production;Proteins;Proteome;Proteomics;Reporting;Reproducibility;Research;Research Personnel;Resolution;response;RNA;Role;Signal Transduction;Somatotropin-Releasing Hormone;Source;Subgroup;Surface;System;Technology;Therapeutic;Time;Tissues;tool;trait;transcriptome;transcriptomics;trophoblast;Ultrasonography;Uterus;Vesicle;vesicular release;Woman

PROJECT_TITLE: Acoustofluidic Separation of Placental Nanovesicle Subpopulations in Obstetrical Diseases

STUDY_SECTION: PN

STUDY_SECTION_NAME: Pregnancy and Neonatology Study Section[PN]


ADMINISTERING_IC: NS

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Genetics;Neurosciences

ORG_CITY: Aurora

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Habituation is a simple form of learning that is disrupted in a wide diversity of heritable brain disorders. Habituation provides a disease-relevant, and accessible model for examining how proteins, synapses, and circuits change in real time to modify behavior. Here, I propose to establish a system that unifies molecular genetic, circuit-level, and behavioral approaches to understand how post-translational palmitoylation influences learning in vivo.

PI_NAMEs: NELSON, JESSICA C (contact)

PROGRAM_OFFICER_NAME: JOHNSON, KARI ANNE

PROJECT_TERMS: Ablation;Acoustic Nerve;Acoustics;Acute;Affect;Age;Anatomy;Animals;Auditory;autism spectrum disorder;awake;Axon;Behavior;Behavioral;Behavioral Genetics;Biochemical;Biological;Biological Assay;Biological Process;Brain;Brain Diseases;BRAIN initiative;Calcium;career;Cells;Cognition;cognitive task;Communication;Complex;Data;Decision Making;Depressed mood;Disease;drug of abuse;Electrophysiology (science);examination questions;Exhibits;experimental study;Fiber;Food;Foundations;Genes;Genetic;Genetic Screening;habituation;Hair Cells;Heritability;Hip region structure;Human;human disease;Huntington Disease;Image;Imaging Techniques;Impairment;in vivo;Individual;insight;interest;Invertebrates;knockout gene;Knowledge;Laboratories;Larva;Lasers;Learning;Maps;member;Microscopy;Modeling;Molecular;Molecular Genetics;Molecular Target;mutant;neural circuit;Neurobehavioral Manifestations;neuronal cell body;Neurons;novel;optogenetics;palmitoylation;Pathway interactions;Pennsylvania;Play;Population;Post-Translational Protein Processing;Potassium Channel;Process;Protein Dynamics;Proteins;Research;response;Role;Schizophrenia;screening;sound;Source;Startle Reaction;Stimulus;Synapses;synaptic function;Synaptic plasticity;System;Testing;Time;Training;Transgenic Organisms;Universities;Vertebrates;Visualization;Zebrafish

PROJECT_TITLE: Understanding how post-translational palmitoylation influences in vivo molecular and circuit dynamics during learning


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Child Abuse and Neglect Research;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Mental Illness;Pediatric;Post-Traumatic Stress Disorder (PTSD);Prevention;Social Determinants of Health;Violence Against Women;Violence Research;Women's Health Research;Youth Violence

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY

ORG_STATE: NY

PHR: Project Narrative Repeated exposure to abuse and neglect substantially increases the likelihood of poor child and adult life outcomes, yet current Child Welfare (CW) family preservation services do not reduce maltreatment recidivism. We propose to determine whether our Parenting Skills Training in Affect and Interpersonal Regulation (P- STAIR), an intervention targeting maternal PTSD-related parenting deficits, would reduce recidivism. If demonstrated efficacious, P-STAIR will reduce maltreatment recidivism among high-risk CW involved mothers, thus ameliorating lives of children and families and reducing maternal stigma, while offering an intervention that is ready for CW dissemination to alter real-world clinical practice.

PI_NAMEs: LINDSEY, MICHAEL A. (contact)

PROGRAM_OFFICER_NAME: GILBERT, LEAH KAYE

PROJECT_TERMS: 2 arm randomized control trial;Abbreviations;abuse neglect;active method;Adult;Adverse effects;Affect;Aftercare;attentional control;Attitude;behavior observation;Blinded;Brain;Case Management;Child;Child Abuse;Child Abuse and Neglect;Child Rearing;Child Welfare;Clinical;clinical practice;Code;Cognitive deficits;Contingent Negative Variation;cost;Counseling;Crime;Crisis Intervention;Data;data registry;depressive symptoms;Development;Diabetes Mellitus;diagnostic criteria;disability;Disease;Disease remission;Dropout;economic cost;efficacy evaluation;efficacy testing;emotion regulation;Enrollment;Ensure;Excision;Exposure to;Family;follow-up;foster care;Health;High Prevalence;high risk;Imprisonment;improved;Injury;intergenerational;Intervention;Investments;Learning;Letters;Life;life span;maltreatment;Measures;Mediating;meetings;Mental Depression;Mental Health;Monitor;Mothers;neglect;New York;New York City;novel strategies;Nursery Schools;Outcome;Parent-Child Relations;parenting intervention;Participant;Phase;physical conditioning;Population;Post-Traumatic Stress Disorders;preservation;prevent;Probability;programs;Randomized, Controlled Trials;recidivism;reduce symptoms;Registries;Regulation;Reporting;Research;Risk;Risk Reduction;Safety;School-Age Population;service programs;Services;skills;social stigma;Standardization;Stroke;suicidal risk;Symptoms;Trauma;Work;young adult

PROJECT_TITLE: Treating Maternal PTSD to Enhance Parenting and Reduce Maltreatment Recidivism: Safe Mothers, Safe Children

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: BOSTON

ORG_NAME: VA BOSTON HEALTH CARE SYSTEM

ORG_STATE: MA

PHR: Due to the COVID-19 pandemic, social distancing guidelines have recommended that individuals stay at home and limit noncritical social contact, which has led to increased feelings of loneliness and social isolation—especially amongst older Veterans. Importantly, social isolation is considered a risk factor for Alzheimer’s disease dementia and may carry consequences for cognitive function. The goal of this grant is to analyze how the pandemic has and continues to engender social and emotional factors that contribute to cognitive decline over time to better understand the long-term effects of the COVID-19 pandemic in older Veterans with and without Alzheimer’s disease, as well as techniques that can be leveraged to correct misconceptions related to social isolation and health. Understanding these complex relationships represents the first step in designing effective interventions to improve the lives of our older Veterans, including those with Alzheimer’s disease.

PI_NAMEs: BUDSON, ANDREW  (contact)

PROJECT_TERMS: Address;Affect;Alzheimer's Disease;Alzheimer's disease risk;Anxiety;Behavior;behavior change;Belief;built environment;Cessation of life;Cognition;Cognitive;cognitive function;Cognitive Science;cognitive testing;Complex;coping;COVID-19 pandemic;Data;Dementia;dementia risk;design;effective intervention;emotional factor;Environment;experience;Feeling;follow-up;Future;Goals;Grant;Guidelines;Health;Hippocampus;Home;human old age (65+);Impaired cognition;improved;Individual;Light;Loneliness;long term COVID-19 pandemic impacts;Measures;Memory Loss;Mental Depression;mild cognitive impairment;military veteran;Misinformation;Modernization;Moods;Neighborhoods;neuroinflammation;Neuropsychological Tests;older adult;Outcome;pandemic disease;pandemic response;Participant;Personality;Personality Character;Persons;physical conditioning;Procedures;Prospective Studies;protective effect;Psyche structure;psychosocial;Questionnaires;Recommendation;recruit;Reporting;Research;Resources;Sampling;SARS-CoV-2 variant;Security;Shapes;Social Behavior;social cognition;social contact;Social Distance;social factors;Social isolation;social relationships;Social support;Stereotyping;Surveys;Techniques;Testing;Time;time interval;United States;Veterans;video chat

PROJECT_TITLE: Consequences of social isolation during the COVID-19 pandemic in older adults with and without Alzheimer's disease


ADMINISTERING_IC: AG

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Sarcopenia

ORG_CITY: SALT LAKE CITY

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Narrative Poor muscle recovery following disuse is frequent amongst older adults leading to low muscle mass, weakness and increased disability. We have proposed to test specific mechanisms of a disrupted macrophage metabolic state during recovery from disuse in aged mice and humans. These findings will produce new knowledge of macrophage metabolism that will aid in the development of therapeutic strategies to promote muscle recovery in aged individuals.

PI_NAMEs: DRUMMOND, MICAH J (contact);O'CONNELL, RYAN M

PROGRAM_OFFICER_NAME: BOYCE, AMANDA T

PROJECT_TERMS: Acceleration;Adopted;age related;aged;Aging;aging population;Anti-Inflammatory Agents;Attenuated;Automobile Driving;bone aging;Bone Marrow;Bone Marrow Cell Transplantation;Bone Marrow Cells;Bone Marrow Transplantation;cell age;Cell Physiology;Cells;Characteristics;Chemicals;Citric Acid Cycle;Classification;Coupled;cytokine;Data;Defect;Development;disability;Disuse Atrophy;Enzymes;Event;Exhibits;experimental study;extracellular;fall risk;falls;Fibrosis;Functional disorder;Future;Genetic;Genetic Transcription;Glycolysis;Growth;Growth Factor;Health;Hematopoietic;Hindlimb Suspension;Human;hypoxia inducible factor 1;Immobilization;Immune system;Impairment;In Vitro;in vivo;Inflammation;Inflammatory;Inflammatory Response;Interleukin-1 beta;Interruption;Invaded;Knowledge;Limb structure;Literature;Long term disability;Macrophage;Macrophage Activation;Mediating;Metabolic;Metabolic Diseases;Metabolism;Methodology;mitochondrial dysfunction;mouse genetics;mouse model;Mus;Muscle;muscle aging;muscle progenitor cell;muscle regeneration;novel;old mice;older adult;Operative Surgical Procedures;Oxidative Phosphorylation;Phenotype;pre-clinical;precursor cell;prevent;programs;Recovery;Recovery Support;reduced muscle mass;Regulation;Resolution;response;restoration;Rodent;Role;sarcopenia;Serum;single-cell RNA sequencing;Skeletal Muscle;stem;stem cell function;Stimulus;Succinates;Testing;Therapeutic;therapeutic development;Transcript;transcription factor;transcriptome;Translating;young adult

PROJECT_TITLE: Regulation of macrophage metabolism in aged muscle during recovery

STUDY_SECTION: ASG

STUDY_SECTION_NAME: Aging Systems and Geriatrics Study Section[ASG]


NIH_SPENDING_CATS: Brain Disorders;Genetics;Neurodegenerative;Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: ANN ARBOR

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Relevance to public health:  The relevance of the proposed studies to public health is that they will define mechanisms triggering neuromuscular degeneration in SBMA. This work is expected to test a novel model of disease pathogenesis, thereby setting the stage for future discovery efforts to develop new therapeutic strategies.

PI_NAMEs: LIEBERMAN, ANDREW P (contact)

PROGRAM_OFFICER_NAME: RANGANATHAN, SRIKANTH

PROJECT_TERMS: 1 year old;Androgen Receptor;Antisense Oligonucleotides;AR gene;Atrophic;Biochemical;Biological Assay;Cell Differentiation process;cell type;Cells;chaperone machinery;Chronic;Data;Defect;Development;Disease;disease model;Exercise Tolerance;experimental study;extend lifespan;Foundations;functional restoration;Future;Gene Targeting;Genetic;Genetic Transcription;Glutamine;Goals;Histologic;Hormones;Human;human embryonic stem cell line;in vivo;induced pluripotent stem cell;innovation;insight;knock-down;Laboratories;men;Metabolic;Modeling;Molecular Chaperones;motor neuron degeneration;Motor Neurons;Mus;Muscle Weakness;Muscular Atrophy;neuromuscular;Neuromuscular Diseases;neuromuscular system;neuron loss;novel;novel therapeutic intervention;Nuclear Translocation;overexpression;Pathogenesis;Pathogenicity;Pathology;Patients;Peripheral;Phenotype;polyglutamine;proteotoxicity;Public Health;Publishing;receptor expression;Receptor-Interacting Protein;Research Design;Skeletal Muscle;skeletal muscle wasting;small molecule;Spinal;spinal and bulbar muscular atrophy;Spinal Cord;targeted treatment;Testing;therapy development;Time;Tissues;Toxic effect;transcription factor;Translating;treatment duration;Ubiquitination;uptake;Work

PROJECT_TITLE: Mechanisms of neuromuscular degeneration in SBMA

STUDY_SECTION: CDIN

STUDY_SECTION_NAME: Chronic Dysfunction and Integrative Neurodegeneration Study Section[CDIN]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Stem Cell Research;Stem Cell Research - Embryonic - Non-Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: CAMBRIDGE

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

PHR: The proposed research explores new mechanisms involved in the assembly and function of ribosomes and their role in stem cells and vertebrate development. These mechanisms will provide valuable insights into the role of the translational apparatus in development and disease. The proposed research is relevant to the part of the NIGMS’s mission that pertains to understanding how living systems work: from molecules and cells to whole organisms.

PI_NAMEs: CALO-VELAZQUEZ, ELIEZER  (contact)

PROGRAM_OFFICER_NAME: VATAKIS, DIMITRIOS NIKOLAOS

PROJECT_TERMS: Address;Biogenesis;Biological Models;Biology;Cell Physiology;cell type;Cells;Defect;design;Development;Disease;DNA-dependent protein kinase;Embryonic Development;Ensure;Gene Expression;Goals;Growth;Hematopoietic stem cells;Heterogeneity;Human;in vivo;in vivo Model;insight;Label;Link;Mission;mRNA Translation;National Institute of General Medical Sciences;Organism;programs;Proliferating;Protein Biosynthesis;protein expression;Regulation;Research;Ribosomes;ribosomopathy;RNA;Role;self-renewal;stem cells;Tissues;tool;Transgenic Organisms;Whole Organism;Work;Zebrafish

PROJECT_TITLE: Mechanisms regulating ribosome assembly and function in stem cells and vertebrate development.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-I(55)R]


NIH_SPENDING_CATS: Aging;Climate-Related Exposures and Conditions;Genetics

ORG_CITY: GALVESTON

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

ORG_STATE: TX

PHR: PUBLIC HEALTH RELEVANCE UV radiation causes a large spectrum of lesions on mitochondrial DNA. We propose to study impact of the UV lesions on mitochondrial genome replication and integrity. The results of the proposed study will lay a solid foundation in understanding UV lesion on aging and human diseases.

PI_NAMEs: YIN, YUHUI  (contact)

PROGRAM_OFFICER_NAME: REDDY, MICHAEL K

PROJECT_TERMS: Active Sites;Aging;Base Pairing;Binding;Binding Sites;Bioinformatics;biophysical techniques;Biophysics;blind;Bypass;Cell Aging;Cell Nucleus;Cells;Code;Complex;Cryoelectron Microscopy;Cyclobutanes;Dermis;dimer;DNA;DNA biosynthesis;DNA Primers;DNA-Directed DNA Polymerase;Elasticity;Electron Transport;Energy Metabolism;Energy Supply;Enzyme Kinetics;Enzymes;Evolution;Exhibits;Family;Foundations;Genes;genome integrity;hallmarks of aging;Health;Human;human disease;in vivo;insight;Introns;Investigation;Ions;Kinetics;Knowledge;Lesion;life span;Location;Longevity;magnesium ion;Maintenance;Manganese;Mediating;member;Memory;Metabolism;Metals;Methods;Mitochondria;Mitochondrial DNA;mitochondrial genome;Mutation;Nuclear;Nucleotide Excision Repair;Nucleotides;Nutrient;Organism;Oxidative Phosphorylation;Oxidative Stress;Physiological;Polymerase;postmitotic;Proliferating;Property;Proteins;public health relevance;Pyrimidine Dimers;repaired;replicase;response;Role;Skin;skin disorder;Solid;Specific qualifier value;stoichiometry;Structure;Sun Exposure;Testing;Tissues;ultraviolet damage;ultraviolet lesions;Ultraviolet Rays;Work;X-Ray Crystallography

PROJECT_TITLE: Mitochondrial translesion DNA synthesis

STUDY_SECTION: MSFB

STUDY_SECTION_NAME: Macromolecular Structure and Function B Study Section[MSFB]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Childhood Leukemia;Genetics;Hematology;Human Genome;Pediatric;Pediatric Cancer;Precision Medicine;Rare Diseases

ORG_CITY: DUARTE

ORG_NAME: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE

ORG_STATE: CA

PHR: Project Narrative  Personalized medicine based on patients' genomic information holds incredible promise for selecting less toxic and more effective cancer treatment. However, there are significant limitations with existing approaches to analyzing the large volume of complex and changing genomic data over the course of disease progression. The goal of this research is to develop and validate a mathematical theory and geometrical method to interpret changes in multidimensional genomic data over time that may eventually be used to predict cancer evolution and response to therapy in the clinic.

PI_NAMEs: KUO, YA-HUEI ;MARCUCCI, GUIDO ;ROCKNE, RUSSELL CHRISTIAN (contact)

PROGRAM_OFFICER_NAME: JOHNSON, ERIC MICHAEL

PROJECT_TERMS: 1q22;Acute Myelocytic Leukemia;behavior prediction;biobank;Biological;Biological Process;Cancer Biology;cancer cell;cancer therapy;CBFbeta-MYH11 fusion protein;Cells;Chromosomal Rearrangement;Clinic;clinical phenotype;Collection;combinatorial;Communities;Complex;Data;design;Development;Dimensions;Disease;Disease Progression;DNA;DNA Methylation;DNA Sequence Alteration;Epigenetic Process;epigenome;Event;Evolution;Experimental Models;experimental study;Explosion;fusion gene;Gene Expression Profile;Genes;Genome;genome-wide;genomic data;Genomics;geometric methodologies;Goals;Health;Hematopoiesis;high dimensionality;High-dimensional Modeling;Human;Immune system;information model;insight;Institution;leukemia;leukemia treatment;Leukemic Cell;Malignant - descriptor;Malignant Neoplasms;Maps;mathematical methods;mathematical model;mathematical theory;Mathematics;Measures;Messenger RNA;Methylation;MicroRNAs;Modeling;Modification;mouse model;Mutation;new therapeutic target;novel;Oncogenic;Onset of illness;Pathogenesis;Pathway interactions;Patients;peripheral blood;personalized medicine;Potential Energy;predicting response;Prediction of Response to Therapy;Probability;Process;Published Comment;Relapse;Research;Rest;RNA;Sampling;Series;System;Systems Biology;targeted treatment;theories;Time;tool;transcriptome;Transgenes;treatment response;tumor progression;Untranslated RNA;Work

PROJECT_TITLE: Information flow and state transitions at the system and multi-dimensional scales in leukemia progression


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Genetics;Hematology;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: MINNEAPOLIS

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PUBLIC HEALTH RELEVANCE STATEMENT MDS-associated RNA splicing perturbations cause aberrant accumulation of R-loops, a group of transcription intermediates consisting of RNA:DNA hybrids and displaced single-stranded DNA. In this proposal, we will investigate how PARP1 senses R-loops in the genome, how it suppresses R-loop-associated DNA damage, and whether the aberrant R-loop accumulation caused by MDS-associated splicing factor mutants can be targeted by PARP inhibition. Successful completion of our studies will provide the mechanistic basis to potentially repurpose PARP inhibitors as targeted therapy for MDS patients harboring splicing factor mutations.

PI_NAMEs: NGUYEN, DANG HAI (contact)

PROGRAM_OFFICER_NAME: DI FRONZO, NANCY L

PROJECT_TERMS: acquired bone marrow failure;Address;ADP ribosylation;Biological Markers;Biology;Blood;Blood typing procedure;Bone Marrow;bone marrow failure syndrome;CD34 gene;Cell Death;Cells;Clinic;Clonal Hematopoietic Stem Cell;cytopenia;Data;Disease;DNA;DNA Damage;Dysmyelopoietic Syndromes;efficacy evaluation;Enzymes;established cell line;FDA approved;Genes;Genetic Predisposition to Disease;Genetic Transcription;Genome;genome-wide;Genomic Instability;Genomics;Hematological Disease;Hematopoietic;Heterozygote;high risk;Human;Hybrids;In Vitro;in vivo;Ineffective Hematopoiesis;Laboratories;Lead;Link;Modality;Modeling;Molecular;Monitor;Mononuclear;mouse model;Mus;mutant;Mutate;Mutation;Myelogenous;novel therapeutics;overexpression;Patients;peripheral blood;Play;Poly(ADP-ribose) Polymerase Inhibitor;Poly(ADP-ribose) Polymerases;pre-clinical;Prevalence;Production;Prognosis;progression risk;Proteins;Proteomics;PTPRC gene;public health relevance;recruit;Regulation;replication factor A;response;RNA;RNA Splicing;Route;Secondary acute myeloid leukemia;Secondary to;sensor;Signal Transduction;Single-Stranded DNA;Site;Source;Spliceosomes;SRSF2 gene;SS DNA BP;stem cell expansion;stem cells;Structure;targeted treatment;Testing;Therapeutic;Translating;Transplantation

PROJECT_TITLE: Implications of PARP1 in myelodysplastic syndromes and targeted therapy

STUDY_SECTION: HTBT

STUDY_SECTION_NAME: Hemostasis, Thrombosis, Blood Cells and Transfusion Study Section[HTBT]


ADMINISTERING_IC: DA

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Drug Abuse (NIDA only);Substance Misuse

ORG_CITY: RICHMOND

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: Project Narrative The objective of this training grant is to continue to educate the future generation of researchers who will concentrate on elucidating the actions of abused substances, understand the behavioral causes and consequences of addiction, and contribute to the development of medications for the prevention and treatment of this disease. Progress in this area requires a work force of researchers with a solid knowledge of the biological processes affected by these substances and by this disease. Those who complete this program will be prepared to have an impact on the health of millions of individuals affected by this disease, their families and all society who currently spend billions of dollars a year on this medical and social problem.

PI_NAMEs: DEWEY, WILLIAM L. (contact)

PROGRAM_OFFICER_NAME: FALCON-MORALES, EDGARDO

PROJECT_TERMS: drug of abuse;Pharmacology;Training

PROJECT_TITLE: Training in the pharmacology of abused drugs


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Infectious Diseases;Nutrition;Prevention

ORG_CITY: ATLANTA

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative The experiments in this proposal are designed to uncover the nutrients and nutritional pathways that are important for C. difficile to form an infectious spore. The project is relevant to the NIH's mission of understanding and preventing bacterial infections and digestive diseases.

PI_NAMEs: MCBRIDE, SHONNA M. (contact)

PROGRAM_OFFICER_NAME: RANALLO, RYAN

PROJECT_TERMS: Affect;Atmosphere;Bacteria;Bacterial Infections;bile salts;Biochemical;Biological Process;Cells;Clostridium;Clostridium difficile;Complex;Cues;Data;design;Development;Diarrhea;diarrheal disease;Dietary Intervention;Digestive System Disorders;Disease;Disinfectants;Energy-Generating Resources;enteric pathogen;Environment;experience;Experimental Designs;experimental study;Exposure to;Feces;Foundations;Gene Expression Regulation;genetic approach;Germination;Goals;Growth;in vivo;Infection Control;Inflammatory;Influentials;Ingestion;innovation;Intestines;Investigation;Knowledge;Life Cycle Stages;Link;Mediating;Metabolic;Metabolism;Mission;Molecular Genetics;Nutrient;Nutrient availability;nutrient deprivation;nutrition;Nutritional;Oxygen;pathogen;Pathogenesis;pathogenic bacteria;Pathway interactions;Play;Potential Energy;preference;prevent;Process;Production;rational design;Regulation;Regulator Genes;Reproduction spores;Research;Resistance;response;Role;Signal Transduction;System;Testing;Toxin;transmission process;United States National Institutes of Health;Virulence;Work

PROJECT_TITLE: Mechanisms Underlying Nutrient-Mediated Sporulation in C. difficile

STUDY_SECTION: BACP

STUDY_SECTION_NAME: Bacterial Pathogenesis Study Section[BACP]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Child Abuse and Neglect Research;Childhood Injury;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Maternal Health;Maternal Morbidity and Mortality;Opioid Misuse and Addiction;Opioids;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Social Determinants of Health;Substance Misuse;Violence Research;Women's Health Research

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Project Narrative The rapid rise in prenatal exposure to prescription and other opioids over the last decade mirrors dramatic trends in opioid use across the general population of the US and in some states nearly one in four pregnancies are exposed to prescription opioids. However, the impact of prenatal opioid exposure on pregnancy and child outcomes, independent of co-occurring factors, remains unclear. This study will support a multilevel examination of individual factors, and the influence of health care and community characteristics, needed to better understand and address the effects of the opioid epidemic on women and their children.

PI_NAMEs: BERGER, LAWRENCE M (contact);EHRENTHAL, DEBORAH BETH

PROGRAM_OFFICER_NAME: CHINN, JUANITA JEANNE

PROJECT_TERMS: addiction;Address;Affect;Age;Alcohols;Automobile Driving;Behavior;Behavior Therapy;Big Data;Binding;Biological;Birth;Birth Records;Caring;Characteristics;Child;Child Abuse and Neglect;Child Development;child protective service;Child Welfare;Clinical;cohort;combat;Communities;community-level factor;Complex;Criminal Justice;Data;Demography;Diagnosis;economic outcome;Education;Employment;Epidemic;Exposure to;Family;Fertility;fetal;fetal opioid exposure;fetal substance exposure;foster care;General Population;Health;Healthcare;improved outcome;Individual;Infant;Knowledge;Life;Link;Live Birth;Low Birth Weight Infant;Maternal and Child Health;maternal cocaine use;maternal opioid use;maternal outcome;Medicaid;medication-assisted treatment;Minority;Mothers;Multiple Partners;Neonatal Abstinence Syndrome;Newborn Infant;Opioid;opioid epidemic;opioid exposure;opioid use;opioid use disorder;Outcome;Pathway interactions;Phase;Policies;Population;Positioning Attribute;Postpartum Period;Pregnancy;Pregnant Women;prenatal;prenatal exposure;prescription opioid;Prevalence;Public Policy;Quasi-experiment;Recommendation;Reporting;reproductive;Research;Research Support;Resources;service programs;Shapes;Siblings;social;Social Environment;Social Welfare;Social Work;socioeconomics;Source;Time;Tobacco;treatment strategy;trend;United States National Institutes of Health;Update;Vulnerable Populations;Wisconsin;Woman

PROJECT_TITLE: Prenatal Opioid Exposure: Birth, health, socioeconomic, and educational outcomes of mothers and their children

STUDY_SECTION: SSPA

STUDY_SECTION_NAME: Social Sciences and Population Studies A Study Section[SSPA]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Aging;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Neurodegenerative;Neurosciences;Parkinson's Disease

ORG_CITY: TYLER

ORG_NAME: UNIVERSITY OF TEXAS TYLER

PHR: PROJECT NARRATIVE The number of Parkinson's disease patients in the USA is increasing at an alarming rate that necessitates the discovery of a more effective treatment that slows the progression of this debilitating disease and replaces currently used symptomatic treatments (e.g., L-DOPA supplement). In this proposal, we are initiating a continuum of research that likely to lead to the development of nicotinic acetylcholine receptors positive allosteric modulators that possess neuroprotective, anti-inflammatory, and precognitive properties that counteract the underlying pathologies of Parkinson's disease. In addition, the proposed research project will also optimize a zebrafish model for screening novel compounds for the above-mentioned therapeutic benefits and thus facilitate the development of novel therapeutics for the treatment of motor symptoms and cognitive decline associated with Parkinson's disease.

PI_NAMEs: HAMOUDA, AYMAN K. (contact)

PROGRAM_OFFICER_NAME: SULLIVAN, LUIS FLANAGAN

PROJECT_TERMS: acetylcholine receptor agonist;Affinity;Agonist;alpha synuclein;American;analog;Anatomy;Animal Model;Animals;Anti-Inflammatory Agents;associated symptom;Award;Behavioral;Binding;Biological;Biomedical Research;Brain;Characteristics;Chemosensitization;Clinical;clinical development;clinically relevant;Cognitive;Cognitive deficits;Communities;cost;Data;Development;Disease;disease phenotype;Disease Progression;Dopamine;dopaminergic neuron;drug development;Drug Screening;Drug Targeting;effective therapy;Effectiveness;Electrophysiology (science);Ensure;experimental study;Future;Goals;high throughput screening;Human;Impaired cognition;improved;In Vitro;in vivo;in vivo evaluation;in vivo Model;insight;Interleukin-1 beta;Isoxazoles;Knowledge;Laboratories;Lead;Lewy Bodies;Ligands;Measurable;Measures;Mission;Modeling;Molecular;Motor;Motor Activity;motor symptom;Mutation Analysis;Neurobehavioral Manifestations;Neurons;neuroprotection;Neurotransmitters;Nicotinic Receptors;novel;novel strategies;novel therapeutics;Oxidopamine;Parkinson Disease;Pathology;Pathway interactions;Patients;Pharmaceutical Preparations;pharmacologic;Pharmacology;pharmacophore;Phenotype;positive allosteric modulator;pre-clinical;Production;programs;Property;Reproducibility;Research;Research Project Grants;Research Training;response;screening;Students;symptom treatment;Symptoms;Testing;Texas;Therapeutic;therapy outcome;Time;undergraduate student;United States National Institutes of Health;Universities;Zebrafish

PROJECT_TITLE: In vitro pharmacology and In vivo neuroprotective effects of CMPI analogues in an optimized Zebrafish model of Parkinsons disease


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Hepatitis;Liver Disease

ORG_CITY: BLACKSBURG

ORG_DEPT: CHEMISTRY

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

PHR: PROJECT NARRATIVE In this project, we will develop novel small molecule mitochondrial uncouplers as therapeutics for the treatment of non-alcoholic steatohepatitis (NASH), a type of fatty liver disease. Key features of these compounds are their selectivity for mitochondria and safety by virtue of their self-limiting properties.

PI_NAMEs: HOEHN, KYLE LEE;SANTOS, WEBSTER L (contact)

PROGRAM_OFFICER_NAME: GARCIA, MARTHA

PROJECT_TERMS: 2,4-Dinitrophenol;Acceleration;Address;Affect;Animal Model;Benchmarking;Biological Assay;Biological Availability;Biopsy;Bypass;Caymans;Cell membrane;Characteristics;Chemicals;Cirrhosis;Clinic;Clinical;Clinical Trials;clinically relevant;Data;design;Diet;Drug Kinetics;drug-like compound;efficacious treatment;efficacy validation;Ensure;Environment;Etiology;Fatty acid glycerol esters;Fatty Liver;fatty liver disease;FDA approved;Fibrosis;Functional disorder;Goals;Hepatic;hepatocyte injury;High Fat Diet;Human;Hyperthermia;Image;improved;In Vitro;in vivo;in vivo evaluation;Inflammation;Inner mitochondrial membrane;innovation;islet amyloid polypeptide;Laboratories;Liver;Liver diseases;Liver Failure;Mediating;mesoxalonitrile;metabolic rate;Mitochondria;Mitochondrial Matrix;mitochondrial therapeutics;Modeling;mouse model;Mus;Nature;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;novel;novel therapeutics;Oral;oxidation;Oxidative Stress;Pathology;Pathway interactions;Patients;Persons;Pharmaceutical Chemistry;Pharmaceutical Preparations;Phase III Clinical Trials;phase III trial;phenylhydrazone;Physiological;Population;preservation;prevent;Primary carcinoma of the liver cells;Process;Production;programs;Property;protein transport;Proteins;Protons;Reactive Oxygen Species;Research;Research Personnel;response;Rodent Model;Safety;scaffold;screening;side effect;small molecule;Source;Specificity;Streptozocin;Structure-Activity Relationship;success;Testing;Therapeutic;Therapeutic Effect;Tissues;tool;Toxic effect

PROJECT_TITLE: Therapeutic Mitochondrial Uncouplers

STUDY_SECTION: SBCB

STUDY_SECTION_NAME: Synthetic and Biological Chemistry B Study Section[SBCB]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Cardiovascular;Clinical Research;Lung;Pediatric;Pulmonary Hypertension;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE Pulmonary hypertension and right ventricular dysfunction can result from the pathophysiology of and therapies used for pediatric acute respiratory distress syndrome (ARDS), a common and deadly syndrome in critically ill children. Morbidity and mortality from pediatric ARDS is primarily driven by cardiovascular failure which can be a direct result of pulmonary hypertension and right ventricular dysfunction. Through serial echocardiographic and plasma biomarker assessments, the goal of this research is to determine the roles of pulmonary hypertension and right ventricular dysfunction in pediatric ARDS outcomes and to identify high risk patients that may benefit from targeted interventions to treat different types of ARDS-associated cardiovascular failure.

PI_NAMEs: HIMEBAUCH, ADAM S. (contact)

PROGRAM_OFFICER_NAME: SUTLIFF, ROY L

PROJECT_TERMS: Acute Respiratory Distress Syndrome;Admission activity;Adult;Affect;Award;Biological Markers;Biometry;Body System;Brain natriuretic peptide;Cardiac Output;Cardiovascular Abnormalities;Cardiovascular system;Cessation of life;Child;Childhood;Childhood Injury;Classification;Clinical;Clinical Research;clinically significant;Cluster Analysis;comorbidity;Critical Care;Critical Illness;Critically ill children;Data;Death Rate;design;Development;Diagnosis;Echocardiography;Endothelium;Epidemiology;Etiology;experience;extracellular vesicles;Failure;Fluid overload;Foundations;Functional disorder;Future;Goals;Heterogeneity;high risk;Hypercapnia;Hypoxemia;imaging modality;Impairment;improved;improved outcome;Infrastructure;inhaled nitric oxide;Injury;Intervention;Intervention Studies;Knowledge;Laboratories;Logistics;Longitudinal cohort study;Lung;lung injury;lung vascular injury;Measures;Mechanical ventilation;Mediating;Mentors;Mentorship;Methods;Morbidity - disease rate;mortality;mortality risk;Multiple Organ Failure;Myocardial dysfunction;N-terminal;novel;novel marker;Organ;Organ failure;Outcome;outcome prediction;Patient-Focused Outcomes;Patients;Pediatric Acute Respiratory Distress Syndrome;Pediatric Hospitals;Pennsylvania;Peptidyl-Dipeptidase A;permissiveness;pharmacologic;Philadelphia;Plasma;Positive-Pressure Respiration;predictive marker;Prevalence;Probability;prospective;Pulmonary Edema;Pulmonary Hypertension;pulmonary vascular disorder;Research;Research Design;Research Personnel;Respiratory Failure;Retrospective Studies;Right Ventricular Dysfunction;Risk Factors;risk prediction model;risk stratification;Role;Scientist;severe injury;Syndrome;targeted treatment;Testing;Training;Translational Research;two-dimensional;United States;Universities;Ventilator;Ventricular

PROJECT_TITLE: The Roles of Pulmonary Hypertension and Right Ventricular Dysfunction in Pediatric Acute Respiratory Distress Syndrome

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(JA)]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Genetics;Mental Health;Mental Illness;Neurosciences;Psychosis;Schizophrenia;Serious Mental Illness

ORG_CITY: Newark

ORG_DEPT: PSYCHIATRY

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: Narrative 3q29 deletion syndrome is associated with a high risk for schizophrenia and other neurodevelopmental and psychiatric disorders, but the reasons for this heterogeneity are not well understood. We will evaluate these phenotypes in 200 individuals with 3q29 deletion syndrome, and assess how sex and background genetic factors may influence the phenotype. We will also compare our data with >2,000 samples from other genomic disorders, to understand how the 3q29 deletion compares to the broader landscape of rare genetic disorders associated with developmental brain disorders.

PI_NAMEs: EPSTEIN, MICHAEL PHILIP;MULLE, JENNIFER GLADYS (contact)

PROGRAM_OFFICER_NAME: PACHECO, JENNIFER LYNN

PROJECT_TERMS: 1q21;22q11.2;3q29;Address;Anxiety Disorders;Articulation;Attention deficit hyperactivity disorder;Attenuated;autism spectrum disorder;Basic Science;behavioral phenotyping;Biological;Biology;Brain Diseases;burden of illness;Caring;clinical phenotype;clinical translation;clinically significant;cognitive ability;cognitive disability;cohort;Collaborations;Collection;Communities;comorbidity;cost;Data;database of Genotypes and Phenotypes;Development;Dimensions;Disease;DNA;Enrollment;Ensure;Evaluation;Executive Dysfunction;executive function;Exhibits;experience;Feasibility Studies;Frequencies;Genes;Genetic;genetic architecture;genome sequencing;Genomics;Genotype;Goals;Heterogeneity;high risk;high risk population;improved;Individual;Investigation;Knowledge;Lesion;Mental disorders;Mental Health;National Institute of Mental Health;Neurodevelopmental Disorder;neuropsychiatric disorder;neuropsychiatry;pandemic disease;Parents;patient mobility;Phenotype;phenotypic data;Population;Prevalence;proband;Protocols documentation;Psychoses;psychosis risk;Psychotic Disorders;public database;rare genetic disorder;rare variant;recruit;Registries;remote assessment;Risk;Sampling;Sampling Studies;Schizophrenia;schizophrenia risk;Severities;sex;Side;Site;Social Behavior;Social disability;Social Functioning;Study Subject;Surveys;Symptoms;Syndrome;Testing;Travel;Universities;whole genome;Work

PROJECT_TITLE: The schizophrenia-associated 3q29 deletion: genetic architecture of behavioral phenotypes

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


NIH_SPENDING_CATS: Bioengineering

ORG_CITY: BETHLEHEM

ORG_DEPT: PHYSICS

ORG_NAME: LEHIGH UNIVERSITY

PHR: PROJECT NARRATIVE This project is relevant to human health because cells detect and respond to flow in order to regulate cardiovascular health, neural growth, and angiogenesis in development and in cancer. The proposed research will determine how fundamental fluid mechanics and membrane biophysics contribute to flow sensing in cells. This work will contribute to the part of the NIH's mission that seeks to understand general principles that underly biological functions.

PI_NAMEs: HONERKAMP-SMITH, AURELIA R (contact)

PROGRAM_OFFICER_NAME: TAYLOR, VERONICA

PROJECT_TERMS: Affect;angiogenesis;aqueous;Arterial Fatty Streak;Atherosclerosis;Biochemical;Biological Models;Biological Process;biophysical properties;Biophysics;Blood flow;Blood Pressure;Blood Vessels;Bone Density;cardiovascular health;Cell Line;Cell membrane;cell motility;Cell Physiology;Cells;Communication;Complex;Confocal Microscopy;Coupling;Development;drug discovery;Endothelial Cells;Environment;experience;experimental study;extracellular;Extracellular Domain;fluid flow;fluidity;Friction;Glass;Glypican;Goals;healing;Health;Heparan Sulfate Proteoglycan;Homing Behavior;Human;Individual;interest;Label;Lateral;lens;Lesion;link protein;Lipids;Liquid substance;Malignant Neoplasms;Measures;mechanical stimulus;Mechanics;mechanotransduction;Mediating;Membrane;Membrane Lipids;membrane model;Membrane Proteins;Membrane Transport Proteins;Methodology;Microfluidics;Mission;Modeling;Molecular;monolayer;Motility;Motion;Movement;Neoplasm Metastasis;neural growth;Nitric Oxide;Nitric Oxide Synthase;novel therapeutics;Oncogenes;Pathology;Physics;Physiological;Plasma Cells;Play;Process;Production;Property;protein function;Protein Sortings;protein transport;Proteins;Proteoglycan;Publishing;reconstitution;Reporting;Research;response;Role;self-renewal;shear stress;Signal Pathway;Signal Transduction;Signaling Molecule;Solid;Sorting;Surface;Tertiary Protein Structure;Testing;Tissues;Translating;Transmembrane Transport;transmission process;tumor;United States National Institutes of Health;Visualization;Work

PROJECT_TITLE: Full Sail Ahead: How Membranes Move and Respond to Flow

STUDY_SECTION: BBM

STUDY_SECTION_NAME: Biochemistry and Biophysics of Membranes Study Section[BBM]


ADMINISTERING_IC: NR

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Prevention;Rural Health;Social Determinants of Health;Telehealth

ORG_CITY: MILWAUKEE

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

PHR: Engagement in HIV medical care and adherence to HIV medications are both essential in improving health outcomes among people living with HIV (PLH), but PLH living in rural areas—who suffer higher mortality rates than their urban counterparts—can confront multiple barriers to care engagement and adherence, especially as they face the logistical, medical, and social challenges associated with aging. This project will test the efficacy of two interventions—supportive-expressive peer social support groups and strengths-based case management—to determine their impact on health outcomes and quality of life among rural older PLH in the Southern U.S. If efficacious, these interventions could be disseminated by organizations serving rural PLH throughout the U.S. and result in improved health outcomes and quality of life in this population.

PI_NAMEs: PETROLL, ANDREW E;WALSH, JENNIFER LYNN (contact)

PROGRAM_OFFICER_NAME: WILLIS, LEIGH ANDREW

PROJECT_TERMS: acceptability and feasibility;Adherence;Advertisements;Age;age acceleration;Aging;antiretroviral therapy;barrier to care;Baseline Surveys;Blood;Caring;Case Management;cognitive ability;Collection;Communities;comorbidity;Complex;Death Rate;Dependence;depressive symptoms;design;Diagnosis;Discrimination;Dryness;efficacy evaluation;efficacy testing;efficacy trial;eHealth;Enrollment;Epidemic;epidemic preparedness;Evidence based intervention;Face;follow-up;Food Access;Formal caregiver;Gender;Goals;Health;health disparity;health equity;health related quality of life;Healthcare Systems;HIV;HIV diagnosis;Housing;improved;Individual;informal caregiver;Insurance;Intervention;intervention cost;intervention delivery;intervention effect;Manuals;Mediating;Mediator;Medical;medication compliance;Morbidity - disease rate;mortality;Motivation;Newly Diagnosed;older adult;Older Population;Outcome;Participant;peer;Personal Satisfaction;Persons;Pharmaceutical Preparations;Population;primary outcome;Provider;Quality of life;Race;Randomized;recruit;remote assessment;remote delivery;remote intervention;Reporting;Research;Resources;Rural;rural area;rural counties;rural dwellers;rural environment;Rural Population;rural residence;rural setting;Sampling;scale up;secondary outcome;Self Efficacy;service utilization;Services;social;social interventions;Social isolation;social stigma;Social support;Spottings;success;Support Groups;Surveys;Technology;Telephone;Testing;therapy adherence;tool;transmission process;Transportation;Viral;Viral Load result;Work

PROJECT_TITLE: Testing the Efficacy of Two Interventions to Improve Health Outcomes and Quality of Life among Rural Older Adults Living with HIV

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


NIH_SPENDING_CATS: Aging;Diabetes;Nutrition

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: PROJECT NARRATIVE Given the increased burden of diabetes, diabetes-related risk factors and diabetes-associated complications in the US population, advanced research training of physicians and scientists in enhancing metabolic health is increasingly imperative. This training program will provide high quality mentorship, a supportive and nurturing environment, and rigorous preparation for a diverse group of physicians and scientists to develop their research portfolio in enhancing metabolic health.

PI_NAMEs: BERNLOHR, DAVID A;CHOW, LISA SENYE (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TITLE: Training Grant in Diabetes and Endocrinology to Enhance Metabolic Healthspan

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


ORG_CITY: PALO ALTO

ORG_NAME: VETERANS ADMIN PALO ALTO HEALTH CARE SYS

PHR: Over 700,000 Veterans are regularly admitted to one of over 120 VHA hospitals providing inpatient acute medical-surgical, psychiatric and long-term care. Staffing by over 98,000 nursing personnel is a vital part of inpatient services. A significant body of literature demonstrates that both the amount of nurse staffing and the characteristics of the nurses available to provide care effects patient outcomes. The study we propose fills a gap in our understanding of system level decisions on patient outcomes, specifically this will be the first large- scale study that matches nurses to the patients that they care for each shift, allowing for more precise estimates of the effects of nurse staffing on patient outcomes.

PI_NAMEs: PHIBBS, CIARAN S. (contact)

PROJECT_TERMS: Acute;Address;Admission activity;Adverse effects;Advisory Committees;Affect;Bachelor's Degree;Care given by nurses;Caring;Characteristics;Charge Nurses;Clinical Data;Collaborations;Computerized Medical Record;Data;data format;Databases;decubitus ulcer;Development;Discipline of Nursing;Education;Educational Status;Ensure;Environment;Equilibrium;experience;Failure;falls;Hospital Mortality;Hospitalization;Hospitals;Human Resources;improved;Individual;individual patient;Information Systems;innovation;inpatient service;Inpatients;Investigation;Joints;Leadership;Length of Stay;Link;Literature;Long-Term Care;Measures;Medical;Methodology;Methods;Modeling;Nosocomial Infections;novel;Nurse Administrator;Nurses;Nursing Assessment;Nursing Education;Nursing Services;Nursing Staff;Office Nursing;Operative Surgical Procedures;Outcome;Patient Care;patient oriented;Patient-Focused Outcomes;Patients;personalized approach;Process;professional atmosphere;Recommendation;Research Personnel;Risk;Risk Adjustment;risk minimization;Sample Size;shift work;Site;System;Testing;Text;tool;Translations;Veterans;virtual;ward;Work;Workload

PROJECT_TITLE: Understanding the relationship between nurse staffing and outcomes: impact of individual nurse education, expertise, and effort level on individual patient outcomes

STUDY_SECTION_NAME: HSR-5 Health Care System Organization and Delivery and Women's Health[HSR5]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: OVERALL - PROJECT NARRATIVE We are all familiar with some of the components of biological systems – DNA, proteins, cells, organs, individuals – but understanding biological systems involves more than just cataloging its component parts. It is critical to understand the many interactions of these parts within systems, and how these systems give rise to biological functions and responses and determine states of health and disease. The National Resource for Network Biology provides the scientific community with a broad platform of computational tools for the study of biological networks and for incorporating network knowledge in biomedical research.

PI_NAMEs: IDEKER, TREY  (contact)

PROGRAM_OFFICER_NAME: WANG, PEGGY

PROJECT_TERMS: algorithm development;Area;Automobile Driving;Beds;Behavior;Binding;Bioinformatics;Biological;Biological Markers;Biological Process;Biological Sciences;biological systems;Biology;Biomedical Research;Biomedical Technology;Cataloging;Cell Communication;Cell model;Cell Physiology;Cells;Cellular Structures;clinical phenotype;Clinical Trials;cloud storage;Code;Collaborations;Collection;Communities;Complex;computational platform;Computer Hardware;Computer software;computerized tools;Conceptions;Data;Data Set;Databases;deep learning;deep learning model;Developmental Cell Biology;Diabetes Mellitus;Disease;Disease stratification;DNA;Drug Modelings;Ecosystem;Educational workshop;Event;Expert Systems;explainable machine learning;Feedback;Funding;gene function;Generations;Genes;Genetic Risk;Genomics;genomics cloud;Genotype;Goals;Health;improved;Individual;Infrastructure;innovation;International;interoperability;Knowledge;Lead;lens;Life;machine learning model;Malignant Neoplasms;Maps;Mathematics;meetings;Mentors;method development;Methodological Studies;Methods;Mission;Modeling;Molecular Biology;multi-scale modeling;National Institute of General Medical Sciences;Network-based;neuropsychiatric disorder;next generation;novel;Ontology;Organ;Pathway Analysis;Patients;Pharmaceutical Preparations;Phase Transition;Phenotype;pleiotropism;Positioning Attribute;Procedures;programs;Proteins;Proteomics;Protocols documentation;Research;Research Personnel;Resource Development;Resources;response;Running;scaffold;Science;Scientist;Services;single cell analysis;Social Network;software infrastructure;Software Tools;Structure;Students;symposium;System;Technology;technology development;technology research and development;Testing;Tissues;tool;Training;training opportunity;transcriptome;transcriptomics;Visual;Visualization;Work

PROJECT_TITLE: National Resource for Network Biology (NRNB)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-T(40)P]


NIH_SPENDING_CATS: Bioengineering;Biotechnology

PROJECT_TERMS: Advisory Committees;Automobile Driving;bioinformatics resource;Biology;Collaborations;Communication;Communities;community engagement;Databases;Development Plans;Ensure;Event;Funding;Home;Human Resources;Infrastructure;Institution;Internet;Measures;meetings;member;Methods;organizational structure;outreach;Performance;Preparation;Principal Investigator;programs;Progress Reports;Protocols documentation;Publications;Reporting;Research;Resources;Role;Site;software development;Software Tools;Surveys;Technology;technology development;technology research and development;Training;Triage;Vision;web site

PROJECT_TITLE: Administration and Management

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-T]


ORG_CITY: CHICAGO

ORG_NAME: JESSE BROWN VA MEDICAL CENTER

ORG_STATE: IL

PHR: Narrative Respiratory problems are a common cause pain, disability and death of US military veterans and soldiers. Since there are no long-term effective treatments to restore airway function when long segments of the trachea are damaged, we propose to engineer a functional neotrachea using autologously sourced individual cell-only bioinks within a three-dimensional printing platform. The engineered neotrachea will be comprised of cartilaginous, vascular and epithelial tissue that will provide mechanical rigidity, the ability to anastomosis with the native vasculature, and protection from outside exposure, respectively, to support airway function. This new strategy to create functional trachea tissue through a scaffold-free cell printing platform may represent a therapeutic advance to treat veterans and soldiers suffering from airway damage.

PI_NAMEs: ALSBERG, EBEN  (contact)

PROJECT_TERMS: 3-Dimensional;3D Print;Ablation;Address;Affect;airway epithelium;Anastomosis - action;Animals;Autologous;Bacterial Infections;Bathing;Benign;Biochemical;Biocompatible Materials;bioink;biomechanical test;bioprinting;bioscaffold;Blood Vessels;bronchial epithelium;Cartilage;cartilaginous;Cell Communication;Cell Density;Cell Physiology;Cell Proliferation;cell type;Cells;Cessation of life;Chondrogenesis;clinically relevant;combat;Complex;crosslink;Defect;design;Devices;disability;effective therapy;endothelial stem cell;Engineering;Epithelial Cells;Epithelium;Extracellular Matrix;flexibility;Gel;Gelatin;Geometry;Growth Factor;Gunshot wound;healing;Histologic;Histology;Human;Immune response;Implant;in vivo;Individual;Inflammatory Response;Intubation;Lasers;Legal patent;Life;Maintenance;Malignant Neoplasms;Manuals;manufacture;mechanical properties;Mechanics;Mesenchymal Stem Cells;Military Personnel;military veteran;Modeling;Mucous Membrane;Nutrient;Organ;Oryctolagus cuniculus;Pain;particle;Patients;Penetration;Performance;Phenotype;Physical condensation;physical property;Physiological;Polymers;prevent;Printing;Production;Quality of life;Radial;Resolution;respiratory;Respiratory Failure;restenosis;Role;scaffold;self assembly;Soldier;Source;Stents;Structure;Technology;Testing;Therapeutic;Tissue constructs;Tissue Differentiation;Tissue Engineering;tissue regeneration;Tissues;Trachea;Tracheal Stenosis;Tracheostomy procedure;Trauma;Tube;Tubular formation;Vascular System;Vascularization;Vasculogenic;Veterans;Work

PROJECT_TITLE: Multi-tissue type condensations for trachea tissue regeneration via individual cell bioprinting

STUDY_SECTION_NAME: Regenerative Rehabilitation[RRD0]


PI_NAMEs: SANDER, CHRIS  (contact)

PROJECT_TERMS: Adoption;Automobile Driving;Biological;biological systems;Biology;cancer therapy;Cell model;cell type;Cells;Cellular biology;Clinical;combinatorial;Complex;cost;Data;data portal;Databases;design;Development;Disease;Drug Combinations;Ecosystem;Engineering;Fractionation;gene function;Genes;Genetic Transcription;Goals;Human;Individual;Machine Learning;Maps;Mass Spectrum Analysis;Measurement;Measures;Methods;Modeling;Molecular;network models;Network-based;new technology;Normal tissue morphology;novel;Ontology;Organism;Pathway Analysis;Pathway interactions;Pharmaceutical Preparations;Phosphorylation;Positioning Attribute;predictive modeling;programs;protein expression;Protein Interaction Mapping;Proteins;Proteomics;Regenerative Medicine;Resolution;Resources;response;Sampling;single cell genomics;single-cell RNA sequencing;Speed;Techniques;Technology;technology research and development;Time;tissue repair;Tissues;tool;Visualization;Work

PROJECT_TITLE: TR&D 1 - Generating Differential and Dynamic Networks


NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Mental Health;Opioid Misuse and Addiction;Opioids;Prescription Drug Misuse;Substance Misuse

ORG_CITY: JACKSON

ORG_NAME: UNIVERSITY OF MISSISSIPPI MED CTR

ORG_STATE: MS

PHR: Valium and related drugs, referred to as “benzodiazepines” are prescribed widely for the treatment of anxiety disorders, one of the most common psychiatric disorders in the U.S. Benzodiazepines are considered to be among the safest prescription drugs in modern medicine, but they unfortunately are also drugs of abuse. The overall goal of this application is to uncover mechanisms that control the beneficial effects as well as the abuse of benzodiazepines, with the hope of developing drugs for treating BZ addiction.

PI_NAMEs: ROWLETT, JAMES K (contact)

PROGRAM_OFFICER_NAME: MOORE, HOLLY MARIE

PROJECT_TERMS: abuse liability;addiction;Affinity;Agonist;antagonist;Anti-Anxiety Agents;Anticonvulsants;Anxiety Disorders;Aversive Stimulus;Behavior;Behavioral;behavioral economics;benzodiazepine abuse;benzodiazepine misuse;Benzodiazepine Receptor;Benzodiazepines;buprenorphine treatment;Communities;comorbidity;Conflict (Psychology);Data;Development;Diazepam;Dimensions;Disease;drug of abuse;Drug Prescriptions;effective therapy;Effectiveness;epidemiology study;Food;Goals;Grant;Health Personnel;hypnotic;in vivo;Individual;innovation;Knowledge;Lead;Ligands;Light;Macaca mulatta;Mediating;Medical;medication-assisted treatment;Mental disorders;Modeling;Modern Medicine;Muscle relaxants;Naltrexone;nonhuman primate;novel;opioid epidemic;opioid use disorder;Patients;Pharmaceutical Preparations;pharmacologic;Pharmacotherapy;Play;Prevalence;prevent;Primates;Procedures;programs;Property;receptor;Research;response;Role;Schedule;Self Administration;side effect;Substance Use Disorder;Therapeutic;Therapeutic Effect;treatment of anxiety disorders;treatment strategy;Work

PROJECT_TITLE: Anxiolytic Effects and Abuse of BZ Receptor Ligands

STUDY_SECTION: BRLE

STUDY_SECTION_NAME: Biobehavioral Regulation, Learning and Ethology Study Section[BRLE]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Data Science;Genetics;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

PROJECT_TERMS: Address;Algorithms;Amino Acids;autoencoder;Automobile Driving;Biological;Biological Models;Biological Process;biological systems;Biology;Cardiac;Cell Communication;cell community;Cell Cycle Regulation;Cell model;Cells;Chemicals;Communities;Community Networks;Computer software;Data;Data Set;Databases;deep learning model;Detection;Development;Dimensions;Ecosystem;gene function;gene interaction;Genes;Genetic;Human;innovation;lens;Literature;Maps;method development;Methodology;Methods;Modeling;Molecular;multi-scale modeling;network architecture;network models;novel;Ontology;Organelles;Pathway Analysis;Pathway interactions;Population;protein complex;Proteins;Regenerative Medicine;Research Personnel;Resources;scalable algorithms;Scientist;Services;Software Tools;Source;Structure;System;Systems Integration;Technology;technology research and development;Tissues;Training;transcriptome sequencing;Validation;Visualization;Yeasts

PROJECT_TITLE: TR&D 2 - Modeling Multi-Scale Network Architecture


NIH_SPENDING_CATS: Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: ANN ARBOR

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: Building on recent discoveries in polyglutamine-mediated neurodegeneration and brain-expressed ubiquilins, this proposal will use multi-scalar approaches to define disease mechanisms, emphasizing intersections with ubiquitin-dependent pathways in the search for novel therapeutic targets for a group of currently untreatable diseases.

PI_NAMEs: PAULSON, HENRY L (contact)

PROGRAM_OFFICER_NAME: RANGANATHAN, SRIKANTH

PROJECT_TERMS: age related neurodegeneration;Biological;Brain;Cell Nucleus;cell type;Complex;Disease;Elements;Environment;Homeostasis;Impairment;Induced Mutation;innovation;Knowledge;Link;Mediating;Modeling;multicatalytic endopeptidase complex;Nerve Degeneration;Nervous System;Nervous System Disorder;Neurodegenerative Disorders;new therapeutic target;Pathogenesis;Pathogenicity;Pathway interactions;Phase;Phase Transition;polyglutamine;Principal Investigator;Proteins;Quality Control;Research;response;Role;Signal Transduction;success;System;therapeutic target;therapy development;tool;Toxic effect;ubiquilin;Ubiquitin

PROJECT_TITLE: Mechanisms of neurodegenerative diseases: intersections with ubiquitin pathways


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Data Science;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Precision Medicine

PI_NAMEs: BADER, GARY D. (contact)

PROJECT_TERMS: Adoption;Automobile Driving;Biological;Biological Models;biological systems;Biology;Black Box;Cancer cell line;cancer clinical trial;cancer survival;Cell Line;Cells;Classification;Clinic;Clinical Trials;Clinical Trials Design;clinically relevant;cloud based;Collaborations;Complex;Computer software;Data;Data Set;Databases;deep learning;Diagnosis;Disease;Drug Modelings;drug response prediction;Environment;explainable machine learning;Failure;genetic association;Genetic Diseases;genetic risk assessment;genome wide association study;genomic profiles;Genotype;Human;human disease;Image Analysis;improved;Industrialization;innovation;Knowledge;Learning;learning strategy;Machine Learning;machine learning method;machine learning model;Major Depressive Disorder;Malignant Neoplasms;Measures;Medical;Methods;Modeling;neural network;Neurons;open source;Outcome;patient response;Patient-Focused Outcomes;Patients;Pattern;Performance;Persons;Pharmaceutical Preparations;Phenotype;polygenic risk score;precision medicine;Precision therapeutics;predicting response;Predictive Cancer Model;predictive marker;predictive modeling;Process;Proteins;repaired;Resources;response;risk prediction;Saccharomycetales;Sampling;Scientist;Series;Signal Transduction;Statistical Data Interpretation;Structure;supervised learning;System;Techniques;tool;Training;transfer learning;Translating;tumor;Xenograft procedure

PROJECT_TITLE: TR&D 3 - Network Guided Machine Learning


PROJECT_TERMS: Applications Grants;Area;Automobile Driving;Beds;Benchmarking;Bioinformatics;Biological;Biology;biomedical ontology;Biomedical Research;Cardiovascular Diseases;Cell Communication;Cells;Clinical;Clinical Trials;Cloud Computing;Collaborations;Collection;Communities;Community Networks;Data;data portal;design;Detection;Diabetes Mellitus;Disease;Ensure;Feedback;Foundations;Funding;gene function;genome wide association study;Genomics;Goals;Human Resources;Institution;Instruction;Investments;Link;Malignant Neoplasms;Maps;Mathematics;member;Mental disorders;Mission;Neurodegenerative Disorders;new technology;Pathway Analysis;Positioning Attribute;programs;Proteins;Proteomics;Research;Research Personnel;Resources;Running;synergism;Technology;technology development;technology research and development;Testing;Time;tool;transcriptomics;United States National Institutes of Health;Validation

PROJECT_TITLE: Driving Biomedical Projects Portfolio


ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE: Federal regulatory decisions restricting the sale of flavored e-cigarettes are being made without critical evidence and may have adverse, unintended public health consequences. The proposed nationwide randomized controlled trial will be the first to provide the US FDA with critical and definitive information as to the impact of non-tobacco e-cigarette flavors on switching among adult smokers.

PI_NAMEs: SMITH, TRACY TAYLOR;WAGENER, THEODORE LEE (contact)

PROGRAM_OFFICER_NAME: KAUTZ, MARY A

PROJECT_TERMS: Abstinence;Adult;Advocate;Authorization documentation;Basic Science;Behavior;Biochemical;Carbon Monoxide;Cigarette;cigarette craving;cigarette smoke;cigarette smoking;combustible cigarette;cost;Cost Analysis;Costs and Benefits;Data;Decision Making;Dependence;Electronic cigarette;electronic cigarette use;electronic cigarette user;Engineering;Evaluation;Excision;Exhalation;Failure;FDA approved;Future;improved;innovation;Investigation;Legal;Longitudinal cohort study;Manufacturer;Medicine;nicotine craving;Nicotine Dependence;nicotine replacement;Nicotine Withdrawal;Outcome;Participant;Patient Self-Report;Pattern;Policy Maker;Public Health;Randomized;randomized trial;randomized, clinical trials;Randomized, Controlled Trials;Reading;Regulation;Reporting;Research;Risk;Sales;Smoke;Smoker;Smoking;Smoking Behavior;surveillance study;Surveys;Symptoms;Testing;Therapy trial;tobacco flavor;Tobacco use;United States National Academy of Sciences;uptake;vaping;week trial;Withdrawal Symptom;Youth

PROJECT_TITLE: A Comprehensive Evaluation of Tobacco-Flavored vs. Non-Tobacco Flavored E-cigarettes on Smoking Behavior

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-RPHB-P(56)]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Networking and Information Technology R&D (NITRD)

PI_NAMEs: PICO, ALEXANDER R (contact)

PROJECT_TERMS: Algorithms;Automation;Automobile Driving;Bioinformatics;bioinformatics resource;Biology;Biomedical Research;cancer genome;career;Clinical;Code;Collaborations;collaboratory;Communities;community center;community engagement;Computer software;Consumption;Data;Databases;Dedications;Development;Documentation;Ecosystem;Education and Outreach;Educational process of instructing;Educational workshop;Ensure;Event;Fostering;Funding;Goals;Infrastructure;Interest Group;lecturer;Life;LinkedIn;Manuals;Mentors;Methods;migration;Modeling;Online Systems;open source;Paper;Persons;Productivity;programs;Protocols documentation;Provider;Publishing;Research;Research Personnel;Resources;Services;Slide;social media;software development;Software Tools;Stream;Students;symposium;Technology;technology research and development;tool;Training;Training Activity;training opportunity;Training Programs;Twitter;Universities;Visualization;web site;Work

PROJECT_TITLE: Community Engagement


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Ovarian Cancer;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human;Women's Health Research

ORG_CITY: ITHACA

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CORNELL UNIVERSITY

PHR: Project Narrative The proposed study will establish roles of epithelial damage and stromal changes in determining cancer-prone states of the Fallopian tubal epithelium. Our findings will provide an essential basis for identification of unique diagnostic and prognostic biomarkers and development of new therapeutic modalities.

PI_NAMEs: NIKITIN, ALEXANDER Y. (contact)

PROGRAM_OFFICER_NAME: KAI, MIHOKO

PROJECT_TERMS: Biological;Breast Carcinoma;cancer cell;cancer type;Carcinoma;Cell Lineage;cell type;Cells;cellular development;Characteristics;Charge;Clinical;Consensus;Data;Development;Diagnosis;diagnostic biomarker;Disease;Dissociation;Distal;Epithelial Cells;Epithelial ovarian cancer;Epithelium;Frequencies;genetic signature;Genetic Transcription;Genomics;Growth Factor;Heterogeneity;Human;immunoreactivity;Implant;Inflammatory;insight;Malignant - descriptor;Malignant neoplasm of ovary;Malignant Neoplasms;Mammalian Oviducts;Mechanics;Mesenchymal;Modality;Molecular Abnormality;Molecular Profiling;Morphology;Mus;mutant;Mutation;Natural regeneration;Neoplasm Metastasis;novel therapeutics;Organoids;Ovarian;Ovarian Carcinoma;Patients;Population;Predisposition;Prognostic Marker;Prostate carcinoma;re-epithelialization;Reporting;response;Role;Serous;Signal Transduction;stem cell biomarkers;stem cells;Stromal Cells;Stromal Change;Surface;Survival Rate;Symptoms;System;Testing;transcriptome;transcriptomics;treatment response;tumor;Uterus;Woman

PROJECT_TITLE: Cancer-prone cell states of the fallopian tubal epithelium

STUDY_SECTION: MONC

STUDY_SECTION_NAME: Molecular Oncogenesis Study Section[MONC]


ORG_CITY: FORT COLLINS

ORG_NAME: COLORADO STATE UNIVERSITY

PHR: Project Narrative The ability to rapidly and selectively prepare targeted chemical structures is vital for the discovery and production of new medicines. The aim of this project is to provide chemists with new synthetic capabilities that improve access to compounds highly desired in the pharmaceutical industry. Specifically, inexpensive bases are used to promote reactions that streamline the synthesis of functionalized arenes and difluorobenzylic compounds.

PI_NAMEs: BANDAR, JEFFREY S (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TERMS: Address;aryl halide;base;catalyst;Chemical Structure;Chemicals;Coupling;Derivation procedure;drug candidate;Drug Industry;Electron Transport;functional group;Goals;Halogens;Improve Access;improved;Isomerism;manufacture;Medicine;Methodology;Methods;novel;novel therapeutics;operation;Organic Synthesis;Pharmaceutical Preparations;Process;Production;programs;promoter;Reaction;Research;Route;Series;Structure;Work

PROJECT_TITLE: New Synthetic Methodology Enabled by Base-Promoted Halogen and Electron Transfer Processes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-P(55)R]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Genetics;Mental Health

ORG_CITY: BOSTON

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

PHR: 8. Narrative Scientific advances in genetics require complex and novel methods and their application in the complex setting of psychiatric disorders. To reduce the suffering and disability related to mental illness in society, clinical research needs to translate findings from genetics and ongoing developments in the neurosciences into better treatment, prevention, and healthcare strategies. Both psychiatric genetics and translational research need to address underrepresented populations and the impact of health disparities in order to improve population mental health.

PI_NAMEs: BLACKER, DEBORAH L.;KOENEN, KARESTAN C (contact);ONNELA, JUKKA-PEKKA

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: Genetic Research;psychogenetics;Training Programs;Translational Research

PROJECT_TITLE: Training Program in Psychiatric Genetics and Translational Research


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Precision Medicine;Social Determinants of Health;Urologic Diseases

PHR: Project Narrative The surge of targeted therapies into the treatment of metastatic cancer has, in part, been fueled by growing enthusiasm among medical oncologists regarding their potential impact on survival for patients with very poor prognosis. Because of the potential for variations and disparities in access to and use of these high-cost, high stakes therapies, there is a critical and urgent need for population-level research about variations in use and the drivers of these variations. This study uses registry-based clinical, sociodemographic, and treatment data from a large population-based sample of diverse patients with metastatic non-small cell lung cancer, genitourinary cancer, and melanoma, as well as interviews and surveys of their treating medical oncologists, to examine potential variations and disparities in patient use of targeted therapies and to understand the contribution of clinician-level factors to these variations.

PI_NAMEs: VEENSTRA, CHRISTINE  (contact)

PROGRAM_OFFICER_NAME: CRONIN, KATHLEEN A

PROJECT_TERMS: access disparities;Address;Age;Attitude;Automobile Driving;barrier to care;Bladder;cancer care;Cancer Control;cancer diagnosis;cancer type;care delivery;Caring;Clinical;clinical development;Collaborations;cost;County;Data;Data Collection;data registry;Dependence;Development;Diagnosis;Disease remission;Disparity;Disseminated Malignant Neoplasm;Education;effective intervention;Equity;Ethnic Origin;experience;Face;Geography;Goals;Guidelines;health disparity;Immune checkpoint inhibitor;improved;Individual;innovation;Intervention;Interview;kidney cell;kinase inhibitor;Knowledge;Life;Logistic Regressions;Los Angeles;low socioeconomic status;Malignant Neoplasms;Measures;Medical Oncologist;Melanoma;Methodology;Methods;Modeling;Molecular Target;multidisciplinary;neoplasm registry;Non-Small-Cell Lung Carcinoma;novel therapeutics;Patient Care;patient population;Patient Selection;Patients;Pattern;Policies;population based;Population Heterogeneity;Population Research;Population Study;practice setting;Prognosis;provider factors;Race;racial minority;Recording of previous events;Registries;Reporting;Research;Resource-limited setting;Resources;response;rural area;Sampling;sociodemographics;Socioeconomic Status;Surveys;targeted treatment;Urogenital Cancer;Variant;Work

PROJECT_TITLE: A Registry-Based Study of Patterns of Use of Targeted Therapies for Metastatic Cancers in Diverse Populations

STUDY_SECTION: HSOD

STUDY_SECTION_NAME: Health Services Organization and Delivery Study Section[HSOD]


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Networking and Information Technology R&D (NITRD);Nutrition;Obesity;Physical Activity;Prevention;Telehealth

ORG_CITY: STORRS-MANSFIELD

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF CONNECTICUT STORRS

ORG_STATE: CT

PHR: NARRATIVE Existing behavioral weight loss programs focus almost exclusively on individuals and self-regulation, even though it is well established that weight management is a dyadic issue in married and cohabitating couples. The proposed study seeks to identify the optimal components of an innovative mHealth weight management approach for couples. Four dyadic intervention components (dyadic action planning, joint feedback on goal progress, autonomy support training, and home environment modifications) will be tested to determine which components contribute significantly to weight loss.

PI_NAMEs: GORIN, AMY A (contact);TATE, DEBORAH F.

PROGRAM_OFFICER_NAME: HALES, CRAIG MAURICE

PROJECT_TERMS: Behavior Therapy;Behavioral;Black Box;Body mass index;Body Weight decreased;Child Care;Couples;Demographic Factors;demographics;density;design;Development;Dietary intake;Enrollment;Environment;Ethnic Origin;Evaluation;evidence base;Exercise;experience;Experimental Designs;experimental study;Feedback;Food;Frequencies;Future;Geography;Goals;Health;Healthy Eating;Heterosexuals;Home environment;Household;improved;Individual;Informal Social Control;innovation;Interpersonal Relations;Intervention;intervention program;Joints;Life Style;Literature;Mediator;mHealth;mhealth interventions;Modality;Modeling;Modification;Monitor;multiphase optimization strategy;Nature;novel;Outcome;Phase;Physical activity;Preparation;primary outcome;Process;programs;prospective;Publishing;Qualifying;Race;Randomized;Randomized, Controlled Trials;recruit;Resource Sharing;risk sharing;Sampling;sex;Signal Transduction;skills training;smartphone application;Spouses;success;Testing;theories;therapy development;Time;Training Support;Travel;treatment response;Weight;Weight Gain;weight loss intervention;weight loss program;Weight maintenance regimen;Work

PROJECT_TITLE: Optimizing a couples-based mHealth intervention for weight management

STUDY_SECTION: LCBH

STUDY_SECTION_NAME: Lifestyle Change and Behavioral Health Study Section[LCBH]


ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: YORK

ORG_NAME: ASSOCIATION OF FOOD AND DRUG OFFICIALS

PHR: RFA-FD-22-021 AFDO’s System for Agriculture, Food, Health, E-Inspections and Registration (SAFHER): Project Narrative The Association of Food and Drug Officials’ (AFDO) efforts under this cooperative agreement are intended to support the planning, development, implementation, operation, and maintenance of data management system to be utilized by State, Local, Tribal, and Territorial (SLTT) partners in both human and animal food programs. AFDO will build on an already established user community of stakeholders to enhance FDA’s ORA Data Exchange capabilities by utilizing software development methodologies (i.e. Agile) to ensure a long-term sustainable data management system that is easy to use and maintain by state regulatory partners during and after this cooperative agreement. Through effective governance, vendor procurement, and resource management, this project will deliver a national regulatory data repository that will work towards achieving a national Integrated Food Safety System (IFSS) while promoting One Health and supporting domestic mutual reliance initiatives to protect the food supply and advance public health.

PI_NAMEs: MANDERNACH, STEVEN  (contact)

PROGRAM_OFFICER_NAME: LAC, ANH

PROJECT_TITLE: System for Agriculture, Food, Health, E-inspection, and Registration (SAFHER)


NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Obesity;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: SEATTLE

ORG_DEPT: ADMINISTRATION

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE This study will assess the impact of a major change to school food policy—the Community Eligibility Provision—which allows high-poverty schools to provide free meals to all children regardless of individual income. We will assess whether the universal free meals under this policy impact child obesity and obesity disparities.

PI_NAMEs: JONES-SMITH, JESSICA C (contact)

PROGRAM_OFFICER_NAME: CAPPS, RANDOLPH CHRISTOPHER

PROJECT_TERMS: Address;Adoption;Affect;Asian;Behavior;Black race;Body mass index;Body Weight;California;Calories;Censuses;Characteristics;Charge;Child;Childhood;cohort;Communities;Consumption;cost;Data;Data Aggregation;Data Sources;Disparity;Eating;Economic Factors;Economics;Eligibility Determination;Environmental Risk Factor;Ethnic Origin;experience;Exposure to;Family;fifth grade;Food;food insecurity;Food Policy;food security;Goals;Health;health data;Health Food;Health Promotion;Heterogeneity;Household;Hunger;Income;income disparities;Individual;Intervention;Latinx;Literature;Longitudinal cohort;Low income;Measures;Mediating;Medical Records;Methods;Native Americans;Natural experiment;ninth grade;Obesity;obesity in children;obesity prevention;obesity risk;Outcome;Pathway interactions;Personal Satisfaction;Physical activity;Policies;Population;Poverty;Prevalence;prevent;Price;programs;Proxy;Public Health;Race;racial disparity;safety net;Sampling;school district;Schools;seventh grade;Sleep;social;social determinants;Source;Stress;structural determinants;Structural Racism;Time;Time trend;Variant;Weight;Work

PROJECT_TITLE: Impact of Universal Free Meals on Childhood Obesity Risk and Obesity Disparities

STUDY_SECTION: SSPB

STUDY_SECTION_NAME: Social Sciences and Population Studies B Study Section[SSPB]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: The goal of this work is to apply new approaches my lab has developed for remote control of synaptic function to understand how different forms of neural plasticity relate to cognitive functions like learning and memory. These experiments will help us understand how synapses in the brain are altered during normal learning and how memory is disrupted in the context of brain diseases and disorders.

PI_NAMEs: KENNEDY, MATTHEW J (contact)

PROGRAM_OFFICER_NAME: CHURN, SEVERN BORDEN

PROJECT_TERMS: Address;Biochemistry;Brain;Brain Diseases;Cellular biology;Central Nervous System;cognitive function;Communication;Development;experimental study;Goals;in vivo;Information Storage;Knowledge;Learning;Link;Memory;Modification;Molecular;neural;Neuronal Plasticity;Neurons;novel strategies;remote control;Shapes;Structure;Synapses;synaptic function;Synaptic plasticity;Time;tool;Work

PROJECT_TITLE: Novel approaches for interrogating and manipulating synaptic function, structure and plasticity


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences;Women's Health Research

ORG_CITY: CAMBRIDGE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

ORG_STATE: MA

PHR: Narrative Alzheimer’s Disease (AD) is a devastating neurodegenerative disease that is the most common cause of dementia, and a significant healthcare burden worldwide. This condition results in progressive memory loss and cognitive decline, which lead to dramatic repercussions for affected individuals and their families. Many genetic studies have identified sex differences to be a critical factor in AD risk, progression, and severity across individuals, but precisely which sex-related mechanisms are responsible for these differences remain unknown. These studies systematically dissect the mechanisms underlying these observed differences using cutting-edge experimental and computational methods to predict sex-specific causal variants, regulatory regions, genes, and pathways; and systematic experimental characterization of predicted drivers using mouse models to better understand the mechanistic basis of sex-related differences in AD. These results will form the foundation for a deeper understanding of AD and new therapeutic development against this devastating disorder.

PI_NAMEs: KELLIS, MANOLIS  (contact);TSAI, LI-HUEI

PROGRAM_OFFICER_NAME: CHAKROBORTY, SHREAYA

PROJECT_TERMS: Address;Affect;Age;age related changes;Alleles;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease risk;Amyloid;Autopsy;Biological Assay;Blood - brain barrier anatomy;Brain;brain cell;brain control;Brain region;Categories;causal variant;cell type;Cells;Cerebrovascular system;Chromosome Mapping;cohort;Computing Methodologies;Data;Data Set;Dementia;Development;Disease;Dissection;DNA;Electronic Health Record;Enhancers;epigenomic profiling;epigenomics;Family;Female;Foundations;frontal lobe;Functional disorder;Gene Expression Profile;Genes;Genetic;Genetic Risk;genetic signature;Genetic study;Genetic Transcription;Genomics;Genotype;healthcare burden;Heterogeneity;Hi-C;Hippocampus;Homeostasis;Hormonal;Human;human induced pluripotent stem cells;Image;Impaired cognition;in vitro Model;Individual;induced pluripotent stem cell;Intervention;Life;Link;Lipids;male;Maps;Memory Loss;Metabolic;Modeling;Molecular;Molecular Mechanisms of Action;mouse model;Mus;Mutation;Neurodegenerative Disorders;novel therapeutics;Nucleic Acid Regulatory Sequences;Pathway interactions;Patients;personalized medicine;personalized therapeutic;Phenotype;Physiological;promoter;Regulatory Element;Resolution;Resources;Risk;risk variant;Sampling;Severities;Severity of illness;sex;Sex Differences;single cell ATAC-seq;single-cell RNA sequencing;Synaptic plasticity;System;Testing;therapeutic development;Transcription Alteration;Untranslated RNA;Validation;Variant;XCL1 gene

PROJECT_TITLE: Single-cell epigenomic and trancriptional dissection of sex-specific differences in Alzheimer’s Disease


NIH_SPENDING_CATS: Genetics

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Narrative To integrate chromatin remodeling and histone modifying events with the complex orchestration of transcription enzymology and reveal timescales and kinetics by which epigenetic and transcription proteins operate on chromatin substrates, this proposal aims to use using state-of-the-art single-molecule imaging techniques, biochemistry and molecular genetics, to identify key reaction intermediates, order of events, and rate-limiting steps that will advance basic, mechanistic understanding of genome expression control with high impact on other areas of eukaryotic DNA metabolism.

PI_NAMEs: WU, CARL  (contact)

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TERMS: Architecture;Area;Biochemical;Biochemistry;Cells;Chromatin;chromatin remodeling;Complex;DNA Binding;DNA metabolism;Enhancers;Enzymatic Biochemistry;Enzymes;Epigenetic Process;Event;Gene Expression;Genes;Genetic Transcription;Genome;histone modification;Histones;Imaging Techniques;Immobilization;In Vitro;Kinetics;Knowledge;Molecular Genetics;Nucleosomes;promoter;Proteins;Reaction;single molecule;Structure-Activity Relationship;transcription factor;Yeasts

PROJECT_TITLE: Kinetic Mechanisms of Chromatin Remodeling and Transcription

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Clinical Research;Clinical Trials and Supportive Activities;Data Science;Digestive Diseases;Dissemination and Implementation Research;Health Services;Liver Disease;Patient Safety;Precision Medicine;Prevention

ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: PROJECT NARRATIVE End-stage liver disease places a disproportionately large burden on the healthcare system with certain individuals experiencing frequent repeat hospitalization and emergency room visits. Healthcare reform can improve outcomes for these individuals if targeted to their needs. The studies proposed will lead to accurate prediction of this vulnerable group by using multi-dimensional data and will establish the feasibility of using novel mobile phone program to improve healthcare use in liver disease. The proposed studies will bring the field closer to providing care that is (1) more aligned to patient goals, (2) adheres to current guidelines, (3) equitable and (4) at a lower cost.

PI_NAMEs: DESAI, ARCHITA P. (contact)

PROGRAM_OFFICER_NAME: LOH, KATRINA SHUEH WEN

PROJECT_TERMS: Admission activity;Algorithms;big data management;Biometry;Brain;Calibration;Caring;Cellular Phone;Chronic Disease;Cirrhosis;cohort;Complement;cost;Data;Data Analyses;Data Correlations;Data Sources;Databases;Dementia;design;Disease Management;Emergency department visit;end stage liver disease;Equity;evidence base;experience;Face;feasibility testing;Future;Goals;Guidelines;Health;health application;health assessment;Health Care Reform;health care service utilization;health data;Health system;Health Technology;Healthcare;Healthcare Systems;high risk;hospital readmission;Hospitalization;implementation science;improved;improved outcome;Individual;innovation;inpatient service;Intervention;Liver;Liver diseases;Measures;Medical Records;Mentors;Mentorship;Methodology;Mobile Health Application;Modeling;multidimensional data;novel;Outcome Measure;Patient Education;patient engagement;patient oriented;Patient Outcomes Assessments;patient population;Patients;Performance;performance tests;personalized medicine;Population;population health;Predictive Factor;predictive modeling;programs;prospective;Prospective cohort;Prospective Studies;readmission rates;Research;Resources;Risk;risk prediction;risk prediction model;skills;socioeconomics;success;Symptoms;Testing;Time;tool;Training;Translating;Vulnerable Populations

PROJECT_TITLE: The Intersection of Personalized Medicine and Implementation Science to Improve Healthcare Utilization in Cirrhosis

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


NIH_SPENDING_CATS: Aging;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Dietary Supplements;Heart Disease;Nutrition;Prevention

PHR: PROJECT NARRATIVE Impaired artery function is a major risk factor for cardiovascular diseases in later middle-aged and older (MA/O; ³50 years) men and women. In the proposed project, I will investigate the effectiveness and underlying molecular mechanisms of oral supplementation with acetate, a molecule derived from the digestion of dietary fiber, to improve artery function with aging in both preclinical mouse models and in humans by conducting a clinical trial in MA/O adults. Overall, the findings of this project have the potential to identify acetate as a new therapy for treating impaired artery function with aging and thereby reducing risk of cardiovascular diseases.

PI_NAMEs: BRUNT, VIENNA E (contact)

PROGRAM_OFFICER_NAME: CATANIA, SELEN MURATOGLU

PROJECT_TERMS: Acetates;Acute;Address;Adult;Advanced Glycosylation End Products;Advisory Committees;age related;Age Years;Aging;American;Aorta;arterial stiffness;Arteries;Ascorbic Acid;Award;Biological Availability;Biopsy;brachial artery;C57BL/6 Mouse;Cardiovascular Diseases;cardiovascular disorder prevention;cardiovascular disorder risk;cardiovascular risk factor;Cardiovascular system;career development;Carotid Arteries;Cause of Death;Circulation;Clinical;clinical development;Clinical Trials;Clinical Trials Design;Collagen;Data;Diet;dietary;Dietary Fiber;Digestion;Double-Blind Method;Down-Regulation;drinking water;effective intervention;Effectiveness;Elasticity;Elastin;Elderly;Endothelial Cells;Endothelium;experimental study;Extramural Activities;Faculty;Female;Femur;Fermentation;FFAR3 gene;Fiber;Functional disorder;Funding;Future;Genes;Genetic Transcription;Goals;Growth;gut microbiome;Health;Health Benefit;Human;human subject;Impairment;improved;in vivo;Incubated;Infusion procedures;innovation;Institution;Intake;International;Intervention;Knock-out;Laboratories;Learning;male;Mediating;member;men;Mentors;Mentorship;middle age;mimetics;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;National Heart, Lung, and Blood Institute;NG-Nitroarginine Methyl Ester;Nitric Oxide;Nitric Oxide Synthetase Inhibitor;Nonesterified Fatty Acids;novel;novel therapeutic intervention;novel therapeutics;old mice;older adult;Oral;oral supplementation;Oxidative Stress;Pathology;Phase;Physiologic pulse;Placebo Control;Placebos;Plasma;Population;Positioning Attribute;post intervention;Postdoctoral Fellow;pre-clinical;prevent;Production;Proteins;Public Health;Randomized;Reactive Oxygen Species;receptor;Recording of previous events;Research;Research Personnel;Research Priority;Research Project Grants;response;Risk Reduction;Role;Scientist;seal;Serum;skills;Small Interfering RNA;soluble fiber;Structural Protein;Superoxide Dismutase;Superoxides;Supplementation;Surface;Technical Expertise;tempol;tenure track;Training;transcription factor;Translating;translational approach;translational study;United States National Institutes of Health;Vascular Endothelium;Volatile Fatty Acids;Woman

PROJECT_TITLE: Translational Studies of the Short-Chain Fatty Acid Acetate for Improving Age-Associated Arterial Dysfunction

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Mental Health

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

PHR: This program provides a unique interdisciplinary training opportunity for scientists interested in the study of emotion and its relation to mental health and mental illness. Virtually every psychiatric disorder, and many physical disorders, involves a disorder of emotion and we seek to train the next generation of scientists who can make fundamental discoveries in this area and with this new knowledge, develop new empirically validated treatments. Understanding how emotion contributes to these disorders, the mechanisms by which the relevant brain circuits impact peripheral biology and organ systems, will be essential in the development of treatments that include the mind, brain and body and that are essential for optimal health.

PI_NAMEs: DAVIDSON, RICHARD J (contact)

PROJECT_TERMS: Emotions;Research;Training Programs

PROJECT_TITLE: Training Program in Emotion Research


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Nutrition;Prevention

ORG_STATE: MI

PHR: PROJECT NARRATIVE Maintaining a healthy lifestyle is central to managing type 2 diabetes, but the ideal dietary recommendations are uncertain. Building on our earlier research, we plan to compare a plate-method versus a very low- carbohydrate diet to improve the evidence base for dietary recommendations for adults with type 2 diabetes.

PI_NAMEs: SASLOW, LAURA  (contact)

PROGRAM_OFFICER_NAME: GOROSPE, RAFAEL

PROJECT_TERMS: Address;Adherence;Adult;Adverse effects;American;Area;behavior test;Behavioral;Body Composition;Body mass index;Bone Density;C-reactive protein;Carbohydrates;Chronic Disease;Clinical;comparison control;Constipation;Consumption;cost;Diabetes Mellitus;Diabetic Diet;Diet;dietary;dietary approach;Dietary Intervention;Distress;Eating;Educational process of instructing;evidence base;follow-up;fruits and vegetables;glycemic control;Glycosylated hemoglobin A;Headache;healthy lifestyle;improved;Individual;Inflammation;Insulin Resistance;Intake;interest;Knowledge;Lipids;Long-Term Effects;Macronutrients Nutrition;Measures;Medical;Meta-Analysis;Methods;Monitor;Non-Insulin-Dependent Diabetes Mellitus;nutrition;Nutritional;nutritional guideline;Outcome;Pharmaceutical Preparations;physical conditioning;Practice Guidelines;prevent;primary outcome;Randomized;Recommendation;relapse prevention;Research;Review Committee;sex;side effect;Site;Social support;Testing;Therapeutic Intervention;treatment arm;treatment guidelines;Weight

PROJECT_TITLE: Comparing Two Dietary Approaches for Type 2 Diabetes

STUDY_SECTION: BMHO

STUDY_SECTION_NAME: Biobehavioral Medicine and Health Outcomes Study Section[BMHO]


NIH_SPENDING_CATS: Biotechnology;Hematology;Immunotherapy;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: Project Narrative The ability to place and retain hematopoietic stem cells in the bone marrow after transplantation requires preparative treatments. This project aims to study the role of nanometer size vesicles released by hematopoietic stem cells to increase engraftment into niches and avoid toxic conditioning.

PI_NAMEs: KURRE, PETER  (contact)

PROGRAM_OFFICER_NAME: BAI, C BRIAN

PROJECT_TERMS: Acute Myelocytic Leukemia;Adoptive Transfer;allogeneic disease;Allogenic;Autologous;Back;Biogenesis;Biological;Blood Tests;Blood Vessels;Bone Marrow;Candidate Disease Gene;CD34 gene;Cell Cycle;Cell Physiology;Cells;cellular targeting;Complex;conditioning;CRISPR/Cas technology;Cues;Data;Defect;Development;disabled;Disease;effective therapy;Elements;Endothelial Cells;Engraftment;Event;extracellular vesicles;fitness;FRAP1 gene;functional outcomes;gene therapy;Generations;Genetic;Goals;Hematologic Neoplasms;Hematopoiesis;Hematopoietic;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;Homeostasis;Homing;Homologous Transplantation;improved;improved outcome;In Vitro;in vivo;Inflammatory;insight;Integrins;interest;Knowledge;leukemia;Measures;Mediating;Melanoma differentiation associated gene-9;Membrane;MicroRNAs;Modeling;Mus;nanoscale;Non-Malignant;novel strategies;Outcome;Output;paracrine;Pathway interactions;Patients;permissiveness;pharmacologic;Population;Process;programs;Proliferating;Property;Proteins;receptor;regenerative;Regenerative capacity;Regulation;RNA;Role;self-renewal;Shapes;side effect;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Specificity;stem cell differentiation;stem cell engraftment;stem cell function;stem cell gene therapy;stem cell migration;stem cell niche;Stimulus;Stress;Stromal Cell-Derived Factor 1;Supporting Cell;System;Testing;Tissues;Toxic effect;trafficking;trait;Transplant Recipients;Transplantation;Transplantation Conditioning;transplantation therapy;uptake;Vascularization;Vesicle;vesicular release;Work

PROJECT_TITLE: Hematopoietic stem and progenitor cell regulation of the niche through extracellular vesicles

STUDY_SECTION: HTBT

STUDY_SECTION_NAME: Hemostasis, Thrombosis, Blood Cells and Transfusion Study Section[HTBT]