NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;HIV/AIDS;Immunotherapy;Infectious Diseases;Lung;Natural Products;Orphan Drug;Rare Diseases;Tuberculosis

ORG_CITY: SAN ANTONIO

ORG_NAME: TEXAS BIOMEDICAL RESEARCH INSTITUTE

PHR: PROJECT NARRATIVE Co-infection with Human Immunodeficiency Virus (4) and tuberculosis (TB) causes extensive mortality. Identifying the molecular mechanisms that drive progression to TB disease following HIV co-infection is critical for developing improved treatment strategies. Using our well-established and faithful nonhuman primate model, we propose to test our hypothesis that both TB as well as HIV infection result in the expression of deleterious pathways /production of deleterious metabolites for immunity, and that blocking these pathways can prevent disease progression.

PI_NAMEs: MEHRA, SMRITI  (contact)

PROJECT_TERMS: antiretroviral therapy;Antitubercular Agents;attributable mortality;B-Cell Activation;Caring;Cause of Death;CD4 Positive T Lymphocytes;Cell Count;Cells;Cessation of life;Chronic;Clinical;co-infection;cytokine;Data;Dendritic Cells;Development;Dioxygenases;Disease;Disease Progression;Equilibrium;Exhibits;experimental study;Flow Cytometry;Granuloma;HIV;HIV Infections;HIV/TB;Human;human tissue;Image;Immune;immune activation;Immune Evasion;Immune response;Immune system;Immunity;Immunocompetent;Immunologic Markers;immunosuppressed;Immunosuppression;improved;improved outcome;Incidence;Individual;indoleamine;Indoles;Infection;Infection Control;Inflammatory;insight;interdisciplinary approach;Interferons;interstitial;Kinetics;Kynurenine;Lung;Macaca;Macaca mulatta;Macrophage;Measures;Mediating;microbial;Modeling;Molecular;mortality;Mycobacterium tuberculosis;Nature;nonhuman primate;novel;Outcome;Pathology;Pathway interactions;Persons;PET/CT scan;prevent;Production;programmed cell death ligand 1;protein expression;Proteins;Public Health;recruit;Regulatory T-Lymphocyte;response;Risk;Role;Sampling;single-cell RNA sequencing;Site;SIV;T-Lymphocyte;targeted treatment;Testing;Therapeutic Intervention;therapeutic vaccine;Tissues;Transcript;Treatment Protocols;treatment strategy;Tryptophan;Tryptophan 2,3 Dioxygenase;Tuberculosis;tuberculosis granuloma;tuberculosis immunity;tuberculosis treatment;Tuberculosis Vaccines;Viral Proteins

PROJECT_TITLE: Modulating Indoleamines to Optimize Immunity in the Setting of Mtb/HIV Co-infection


ADMINISTERING_IC: AA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Infectious Diseases;Prevention;Screening and Brief Intervention for Substance Misuse;Substance Misuse

ORG_CITY: SAN FRANCISCO

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: This is a study to develop strategies and pilot test adding testing for and providing results for a blood biomarker of prior month alcohol consumption, phosphatidylethanol (PEth), to a standard brief intervention for unhealthy alcohol use. The brief intervention is being rolled out by the Uganda Ministry of Health (MOH) in HIV care, and the research will be conducted via focus group discussions with persons with HIV, HIV clinic staff, a community advisory board, meetings with MOH members, and field testing and pilot testing the protocols. We will determine the acceptability, appropriateness, and feasibility of adding PEth results to alcohol brief interventions, and decide if a large scale trial is warranted.

PI_NAMEs: HAHN, JUDITH ALISSA (contact)

PROGRAM_OFFICER_NAME: ROACH, DEIDRA

PROJECT_TERMS: Address;Adherence;Age;Alcohol consumption;alcohol intervention;alcohol measurement;alcohol misuse;alcohol risk;alcohol screening and brief intervention;Alcohols;antiretroviral therapy;arm;behavior change;Behavior Therapy;Biological Markers;Blood;blood-based biomarker;brief alcohol intervention;brief intervention;Caring;Clinic;clinical care;Clinical Psychology;co-infection;Cohort Studies;Collaborations;Communication;Communities;community advisory board;comorbidity;cost;Counseling;Country;Diabetes Mellitus;Disease;experience;Feedback;field study;Focus Groups;Future;Glycosylated hemoglobin A;Goals;Government;Health;Health behavior;High Prevalence;high risk;HIV;HIV/TB;Hour;Immunoassay;Impairment;improved;Inflammation;Intervention;Intervention Trial;Interview;Learning;Measurement;Measures;Medical;medication compliance;meetings;member;men;Methods;Monitor;Morals;Morbidity - disease rate;Motivation;Nurses;Outcome;Participant;Patient Self-Report;Patients;Persons;phosphatidylethanol;pilot test;point of care testing;Positive Reinforcements;pre-exposure prophylaxis;Professional counselor;Protocols documentation;Provider;Randomized;Randomized, Controlled Trials;Readiness;recruit;reduced alcohol use;Research;Research Methodology;Research Personnel;Risk;Role playing therapy;routine care;screening;screening and brief intervention;Self Perception;Series;Social Desirability;social stigma;Tenofovir;Testing;Training;Tuberculosis;Uganda;Urine;Viral;Visual;Woman;Work;Writing

PROJECT_TITLE: The Phosphatidylethanol (PEth) Results Communication (PERC) Study

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_CITY: MINNEAPOLIS

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE By capitalizing on recent new insights into brain neurovascular coupling, the goal of this project is to establish and validate a transformative neuroimaging approach that quantifies non-invasively physiological metrics fundamental to brain function, such as oxygen availability, pH and carbon dioxide accumulation in tissue. The project represents a novel direction of research for Dr. Mangia, who will conduct pioneering studies using the proposed novel neuroimaging approach to explore an innovative conceptual framework linking loss of brain function to abnormal accumulations of metabolic waste products.

PI_NAMEs: MANGIA, SILVIA  (contact)

PROGRAM_OFFICER_NAME: BARRETT, PAUL JOHN

PROJECT_TERMS: Award;Biosensor;Blood capillaries;Brain;brain metabolism;brain tissue;Carbon Dioxide;Cerebrovascular Circulation;clinical investigation;Collaborations;Communities;Coupling;Electroencephalography;Excision;flexibility;Foundations;Functional Magnetic Resonance Imaging;Goals;high risk;Homeostasis;imaging modality;imaging platform;Implant;innovation;insight;Institution;Link;Magnetic Resonance Imaging;Maps;mathematical model;Measurement;Measures;Metabolic;Metabolism;Methodology;Microscopic;neuroimaging;Neurons;neurotransmission;neurovascular coupling;novel;novel strategies;optical imaging;Oxygen;Pathologic;Patient Care;Physiological;Physiology;Positron-Emission Tomography;Property;Protons;Regulation;Research;respiratory;Scheme;Study models;Techniques;Theoretical model;Time;Tissues;translational neuroscience;Validation;validation studies;Waste Products;wasting

PROJECT_TITLE: Obtaining brain pCO2, pH and pO2 maps via measurements of neurovascular coupling: a novel non-invasive approach to identify the culprits of loss of brain function

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MBBC-J (70)]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;Gene Therapy;Genetics;HIV/AIDS;Immunization;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: CORAL GABLES

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: Project Narrative Delivery of broadly neutralizing antibodies by viral vectors has the potential to a) mediate long-term protection against HIV acquisition and b) strongly and durably suppress HIV replication in infected individuals; both after a single vector administration. However, naturally preexisting antibodies to such viral vectors in the human population can compromise the applicability of this approach. In this project we propose a set of easy-to-apply approaches to overcome this critical issue and advance the use of the antibody/vector approach against HIV for human use.

PI_NAMEs: MARTINEZ-NAVIO, JOSE MARIA (contact)

PROGRAM_OFFICER_NAME: CASTLEMAN, MORIAH JOVITA

PROJECT_TERMS: Acceleration;adeno-associated viral vector;Affinity;Animals;Anti-Retroviral Agents;Anti-viral Agents;Antibodies;antiretroviral therapy;Berlin;Bypass;Capsid;Capsid Proteins;cellular transduction;Circulation;Clinical Trials;Code;Communicable Diseases;Cost efficiency;cross reactivity;Data;delivery vehicle;detection limit;Development;Dose;effectiveness evaluation;enzyme replacement therapy;experimental study;Exposure to;fighting;Future;Gene Delivery;gene product;gene therapy;Geographic Locations;Goals;Half-Life;HIV;HIV Antibodies;HIV Infections;Human;Immune system;Immunoglobulin G;in vivo;Individual;Infection;Injections;Macaca;Macaca mulatta;Measures;Mediating;Methods;Monkeys;Mus;Neonatal;neonatal Fc receptor;neutralizing antibody;Pathogenicity;Patients;Performance;Persons;Pharmaceutical Preparations;Plasma;Population;prevent;Prevention;prophylactic;Prophylactic treatment;receptor;Recombinant adeno-associated virus (rAAV);Recombinants;Recycling;Reporting;response;Safety;safety and feasibility;Sampling;Satellite Viruses;seropositive;Seroprevalences;Serotyping;Serum;SIV;Sterility;Testing;Time;transduction efficiency;transgene expression;Vaccines;vector;Viral Load result;Viral Vector;Viremia;Virus

PROJECT_TITLE: Overcoming preexisting antibodies to recombinant AAV vectors in rhesus macaques

STUDY_SECTION: HIVD

STUDY_SECTION_NAME: HIV Immunopathogenesis and Vaccine Development Study Section[HIVD]


ADMINISTERING_IC: DA

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cocaine;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: PHILADELPHIA

ORG_DEPT: PHARMACOLOGY

ORG_NAME: DREXEL UNIVERSITY

ORG_STATE: PA

PHR: Project Narrative Human immunodeficiency virus (HIV) and cocaine use disorders (CUDs) are persistent public health concerns within the United States and worldwide. Cocaine use can facilitate the pathophysiology of HIV and preclinical studies suggest that HIV may promote addiction-related behaviors, highlighting the unique biobehavioral interaction underlying the comorbidity of HIV and CUDs. This proposal will employ a cutting-edge combination of preclinical rodent modeling of HIV and CUDs along with quantitative cellular imaging and circuit-specific, closed-loop optogenetics to reveal corticolimbic circuit and neuroimmune contributions to HIV-induced dysregulation of reward-seeking behavior, which will further our understanding of the neurobehavioral underpinnings of comorbid HIV and CUDs.

PI_NAMEs: NAMBA, MARK D (contact)

PROGRAM_OFFICER_NAME: LIN, YU

PROJECT_TERMS: Abstinence;addiction;Animal Model;Animals;antiretroviral therapy;Behavior;Behavioral;biobehavior;Blood;brain tissue;Cd68;cell type;cellular imaging;Central Nervous System;Chemosensitization;Clinical;Cocaine;Cocaine misuse;cocaine relapse;cocaine seeking;cocaine self-administration;cocaine use;Cocaine use disorder;comorbidity;Corpus striatum structure;cortico-limbic circuits;Coupled;Data;designer receptors exclusively activated by designer drugs;Development;Dose;Drug Receptors;effective therapy;experimental study;Extinction;FDA approved;Female;Fiber Optics;Functional disorder;Genetic;genetic manipulation;Goals;HIV;HIV risk;HIV-associated neurocognitive disorder;Immediate-Early Genes;Immune signaling;Impairment;improved;Individual;infected vector rodent;Infection;injection drug use;Invaded;learned behavior;Learning;learning extinction;Light;long term abstinence;male;Mediating;Microglia;Modeling;Morphology;morphometry;motivated behavior;Mus;neurobehavioral;Neurocognitive;Neurocognitive Deficit;Neuroimmune;Neuroimmunomodulation;Neurons;neuropathology;novel;Nucleus Accumbens;Operative Surgical Procedures;opioid epidemic;Opsin;optogenetics;Oral;Outcome;overdose death;Pathway interactions;Peripheral;Persons;Pharmaceutical Preparations;pharmacologic;pre-clinical;preclinical study;Prefrontal Cortex;Procedures;promoter;Proteins;psychostimulant;Public Health;quantitative imaging;Relapse;Research;response;Rewards;Risk Behaviors;Rodent Model;Role;Saccharin;Self Administration;Signal Transduction;stimulant misuse;Stimulant overdose;synaptic function;Techniques;Testing;Therapeutic Intervention;therapeutically effective;Training;United States;Viral;Viral Load result;Viral reservoir;Virus;Virus Replication;Work

PROJECT_TITLE: Corticolimbic circuit and neuroimmune mechanisms of comorbid HIV and cocaine use

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F17A-F (20)]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Clinical Research;Dental, Oral, and Craniofacial Disease;HIV/AIDS;Infectious Diseases;Microbiome

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Periodontal infection (periodontitis) causes loss of the alveolar bone anchoring the teeth and is common in people infected with the human immunodeficiency virus (HIV). Antiretroviral therapy (ART) suppresses HIV replication, ameliorating HIV-disease severity; however, ART-induced immune recovery, is associated with an inflammatory reaction (immune reconstitution bone loss (IRBL)) that causes severe skeletal deterioration. Whether IRBL also degrades alveolar bone in the jaws, promoting tooth loss is unknown, and our studies will hence examine the effects of IRBL on the alveolar bone and the intersection of IRBL with periodontitis in people infected with HIV initiating ART, and in animal models.

PI_NAMEs: UMEIZUDIKE, KEHINDE ADESOLA;WEITZMANN, MERVYN NEALE (contact)

PROGRAM_OFFICER_NAME: BACCAGLINI, LORENA

PROJECT_TERMS: 3-Dimensional;Acquired Immunodeficiency Syndrome;Acute;Adaptive Immune System;Alveolar;alveolar bone;Alveolar Bone Loss;Animal Model;Antibiotics;antiretroviral therapy;Bacteria;Bacterial Antigens;Basic Science;Bioinformatics;bone;Bone Density;bone loss;Bone Marrow;bone mass;CD4 Positive T Lymphocytes;Cell secretion;Cells;Cervical lymph node group;Characteristics;chronic inflammatory disease;Clinical;Clinical Research;Complication;cone-beam computed tomography;Country;cytokine;Data;Deterioration;Disease remission;Drug usage;dysbiosis;Etiology;Event;Flow Cytometry;Fumarates;Generations;Goals;gut bacteria;Health;HIV;HIV anti-retroviral;HIV Infections;IL17 gene;Immune;immune reconstitution;Immunity;Immunoassay;Immunocompromised Host;immunodeficiency;Immunologic Surveillance;immunosuppressed;Impairment;Inflammatory;insight;International;Intervention;Jaw;Ligature;long bone;Mastication;Measures;metagenomic sequencing;microbial;microbiota;microCT;Modeling;Morbidity - disease rate;mouse model;Mouth Diseases;Mus;nano-string;Natural regeneration;Nigeria;novel;nutrition;Oral;oral bacteria;Oral health;oral immunity;oral microbial community;oral microbiome;oral pathogen;oral tissue;Outcome;Pain;Panoramic Radiography;pathogenic bacteria;Periodontal Diseases;Periodontal Infection;Periodontitis;periodontopathogen;Persons;Pharmaceutical Preparations;Porphyromonas gingivalis;prevent;Prophylactic treatment;Prospective cohort;Quality of life;Reaction;reconstitution;Recovery;Reporting;Risk;Role;Running;Scientist;Self Perception;Serum;Severity of illness;Shotguns;side effect;skeletal;soft tissue;Source;standard of care;T-Cell Activation;T-Lymphocyte;Tenofovir;Time;Tissues;TNF gene;TNFSF11 gene;Tooth Loss;Tooth Mobility;Tooth root structure;Tooth structure;Vertebral column;Virus;Work;Zoledronic Acid

PROJECT_TITLE: Intersection of Periodontitis with HIV-Antiretroviral Therapy-Induced Immune Reconstitution Bone Loss, on Alveolar Bone and Tooth Loss, in People Living with HIV

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


PHR: PROJECT NARRATIVE Finding a cure for HIV-1 is challenging since the virus can remain hidden and inactive (latent) inside CD4+ T- cells for years, meanwhile the immune system does not recognize that these cells as infected. Among HIV-1 research, several approaches have been used in combination with existing cART, yet People Living With HIV (PLWH) need to currently maintain life-long daily administration of combination antiretroviral drug therapy (cART) that suppress plasma viremia to undetectable levels, which does not eliminate the viral reservoir. Thus, a niche for new therapies is warranted to achieve an HIV-1 cure.

PI_NAMEs: CORREA, NATALIE SHERECE (contact)

PROGRAM_OFFICER_NAME: MOITRA, KAROBI

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;adeno-associated viral vector;AIDS prevention;Anti-Retroviral Agents;antibody-dependent cell cytotoxicity;Apoptosis;Automobile Driving;Binding;Binding Proteins;CD4 Positive T Lymphocytes;Cell Culture System;Cell Line;Cell membrane;Cell Separation;cell type;Cells;Cessation of life;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;CRISPR/Cas technology;Cytolysis;Data;delivery vehicle;Dependovirus;DNA cassette;DNA Packaging;Engineering;experimental study;gag Gene Products;Gene Expression;gene therapy;Genes;Genetic Transcription;Genome;HIV;HIV-1;HIV-1 integrase;Human;Immune;Immune system;improved;Individual;Induction of Apoptosis;Infection;inhibitor;interest;Interruption;Life;Ligands;Luciferases;Measurable;Mediating;Membrane;Methods;Molecular;Murine leukemia virus;neutralizing antibody;novel;novel strategies;novel therapeutics;pandemic disease;Penetration;Peptide Hydrolases;Peripheral Blood Mononuclear Cell;Persons;Pharmaceutical Preparations;Pharmacotherapy;Plasma;prevent;Production;Proliferating;Property;protein expression;Proteins;Proviruses;Reagent;Recombinants;repaired;Research;Rest;Sampling;Sequence Homology;Shock;side effect;Signal Transduction;Site;small molecule;System;Testing;Therapeutic;Therapeutic Agents;therapeutic protein;TNF gene;tool;Trans-Activators;Transcription Coactivator;Treatment Efficacy;Viral;Viral Genome;Viral Load result;Viral reservoir;Viremia;Virion;Virus;Virus Integration;Virus Replication;Virus-like particle;Vorinostat;Work

PROJECT_TITLE: Developing Virus like Particles for HIV-1 Cure Strategy


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: BRONX

ORG_NAME: JAMES J PETERS VA  MEDICAL CENTER

ORG_STATE: NY

PHR: The Million Veteran Program (MVP) is the largest and most diverse biobank in the world, containing genetic and electronic health record (EHR) data for more than 650,000 Veterans. As a result, the MVP presents a unique opportunity to perform statistical genetic analyses that advance our understanding of biological mechanisms for serious mental illness (SMI) related traits. Nevertheless, a growing body of literature has demonstrated that genomic research is not equitable, in part due to sample size differences and heterogeneity in EHR data quality, obscuring our ability to identify new treatments for SMIs. This proposal mitigates disparities in genomic research by quantifying data quality heterogeneity and aggregating multiple related traits in the EHR to perform meta-analyses that boost power in detecting genetic risk factors for SMI related traits. Since Veterans with SMIs have increased mortality risks, this study is aimed at improving detection and identifying novel genetic targets for improving healthcare outcomes for Veterans from all backgrounds.

PI_NAMEs: BURSTEIN, DAVID  (contact)

PROJECT_TERMS: Affect;Benchmarking;biobank;Biological;Bipolar Disorder;care outcomes;Characteristics;Code;cohort;Communities;Data;Data Aggregation;data integration;data quality;Detection;Diagnosis;Disparity;disparity reduction;Electronic Health Record;Equity;European ancestry;Face;Female;Future;gene environment interaction;Genetic;genetic analysis;Genetic Risk;genetic risk factor;genetic variant;genome wide association study;genome-wide;Genomics;Goals;health care disparity;Heterogeneity;improved;innovation;Laboratories;Lead;Life Expectancy;Link;Literature;Machine Learning;Major Depressive Disorder;male;Measurement;Measures;Meta-Analysis;Methodology;military veteran;mortality risk;novel;Outcome;Outcomes Research;Performance;Pharmaceutical Preparations;Phenotype;phenotypic data;phenotyping algorithm;polygenic risk score;Prevalence;programs;Protocols documentation;Psychiatry;Qualifying;Research;risk prediction;risk stratification;risk variant;Sample Size;Schizophrenia;severe mental illness;sex;Signal Transduction;Subgroup;Techniques;Testing;trait;transcriptome;translational potential;Translational Research;Variant;Veterans;Weight;Work;X Chromosome

PROJECT_TITLE: Mitigating Genomic Research Disparities in the Million Veteran Program

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 MHBA-U (01)]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Infectious Diseases;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Obesity;Pediatric;Pediatric - AIDS;Prevention;Women's Health Research

ORG_CITY: PROVIDENCE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: PROJECT NARRATIVE/PUBLIC HEALTH IMPACT STATEMENT The co-occurrence of HIV infection and obesity has substantial implications for maternal and child health. Given the role of HIV stigma in HIV viral suppression and postpartum weight retention among women living with HIV, an integrated intervention approach is ideal for addressing these dual outcomes among a critical population, postpartum women. This study seeks to refine and test an integrated HIV treatment and postpartum weight retention intervention for postpartum women living with HIV.

PI_NAMEs: KNIGHT, LUCIA ;PELLOWSKI, JENNIFER ANN (contact)

PROGRAM_OFFICER_NAME: STIRRATT, MICHAEL JAMES

PROJECT_TERMS: Address;adverse outcome;Africa South of the Sahara;AIDS diagnosis;antenatal;antiretroviral therapy;Area;Behavior Therapy;Behavioral;Birth Rate;Body mass index;Body Size;Body Weight decreased;Cardiovascular Diseases;Caring;Cesarean section;child bearing;Clinic;Clinical;combat;Communities;Data;Data Collection;design;efficacy testing;efficacy trial;Evaluation;excessive weight gain;experience;Face;Family member;Feedback;Fetus;Focus Groups;follow up assessment;Future;gestational weight gain;Goals;Health;Health behavior;Healthy Eating;High birth weight infant;HIV;HIV Infections;HIV Seronegativity;HIV Seropositivity;Hypertension;improved;Individual;Infant Care;Intervention;Interview;Life;Maternal and Child Health;Maternal Health;Methods;Modeling;Mothers;Non-Insulin-Dependent Diabetes Mellitus;Obesity;obesity in children;Outcome;Outcome Assessment;Participant;patient population;Perception;Physical activity;pilot trial;Policy Maker;Population;post intervention;Postpartum Period;postpartum weight;Postpartum Women;preference;Pregnancy;Pregnant Women;Prevention;Production;Public Health;Randomized, Controlled Trials;Research;Risk;Role;Self Care;social stigma;South Africa;South African;Special Population;Techniques;Testing;therapy adherence;therapy design;treatment adherence;trend;Viral;Weight;Weight Gain;Woman;Work

PROJECT_TITLE: HIV viral suppression and prevention of postpartum weight retention in South Africa: A pilot trial


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Mental Health;Pediatric;Pediatric - AIDS;Prevention;Social Determinants of Health

PHR: PROJECT NARRATIVE The HIV/AIDS epidemic continues to be one of the world’s most serious public health challenges. Restrictions in population movements and suspensions in health services due to the COVID-19 pandemic caused widespread disruption to HIV service utilization in many HIV endemic settings, including South Africa. Using harmonized data from multiple national surveillance systems across South Africa, we will employ an agent- based modeling approach to establish applied methods for estimating disruptions in progress towards ending HIV/AIDS and identifying social and psychological factors that hypothetical interventions can target to alleviate individual-level risk factors for poor HIV prevention and care outcomes in the context of a disruptive event.

PI_NAMEs: GIOVENCO, DANIELLE  (contact)

PROGRAM_OFFICER_NAME: SCOTT-SHELDON, LORI ANN JENNIFER

PROJECT_TERMS: Accounting;Acquired Immunodeficiency Syndrome;Affect;Africa South of the Sahara;African;AIDS prevention;antiretroviral therapy;Applications Grants;Asian;Award;Back;burden of illness;care outcomes;career;Collaborations;Communities;Conflict (Psychology);contextual factors;Country;COVID-19;COVID-19 impact;COVID-19 pandemic;COVID-19 pandemic effects;Data;data harmonization;Data Science;Data Sources;Databases;design;Diagnosis;Drops;Economics;Education;Educational workshop;Ensure;Environment;Epidemic;Epidemiologic Methods;Epidemiology;epidemiology study;Event;experience;Foundations;Funding;Future;Generations;global health;Goals;Health care facility;health care quality;health determinants;health disparity;Health Services;HIV;HIV diagnosis;HIV Infections;HIV risk;HIV/AIDS;Household;Human immunodeficiency virus test;Incidence;Individual;International;Interruption;Intervention;intervention program;Knowledge;Language;Longitudinal trends;Manuscripts;meetings;Mental Health;Mentors;Methods;Modeling;Modification;mortality;multidisciplinary;national surveillance;Natural Disasters;new epidemic;Outcome;pandemic disease;Persons;Policies;Policy Maker;Population;population movement;Predictive Factor;Prevalence;prevent;programs;Psychological Factors;Public Health;public health emergency;Reporting;Research;research data dissemination;response;Risk Estimate;Risk Factors;Role;Secure;Series;service utilization;skills;social determinants;social factors;social health determinants;South Africa;South African;Southern Africa;Surveys;Suspensions;symposium;System;Techniques;Time;Time Series Analysis;Training;Training Activity;Training Programs;treatment program;Viral;Work

PROJECT_TITLE: Preventing disruptions in progress towards ending HIV/AIDS: Lessons from the COVID-19 pandemic

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Mental Illness;Pediatric;Pediatric - AIDS;Prevention;Social Determinants of Health

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE A majority of mental health care needs in Africa continue to go unmet despite existence of evidence-based interventions such as problem-solving therapy that can circumvent resource-related challenges to the provision of care— a reality that is particularly harmful for people with comorbid HIV and depression who are more likely to experience delays in diagnosis, treatment initiation, and viral suppression compared to their mentally well counterparts. The proposed study will draw from patient and provider preferences regarding the distinct features of mental health care implementation to formulate and pilot test a stepped problem-solving therapy implementation approach comprised of one lower- and higher-resource implementation strategy. Ultimately, I aim to engage in the training and research necessary to understand the feasibility of using adaptive mental health care implementation approaches in KwaZulu-Natal Province, South Africa, thereby supporting equitable physical and mental health outcomes for people with HIV in resource-constrained settings.

PI_NAMEs: FILIATREAU, LINDSEY  (contact)

PROGRAM_OFFICER_NAME: SENN, THERESA ELAINE

PROJECT_TERMS: Achievement;Address;Africa;care outcomes;Caring;Client;Cognitive Therapy;Collaborations;Communicable Diseases;Communities;community advisory board;community setting;comorbidity;Complex;Country;Data;Depressed mood;depressive symptoms;design;Development;Diagnosis;efficacy outcomes;Ensure;Epidemiologic Methods;Equity;Evaluation;evidence base;Evidence based intervention;Evidence based treatment;experience;Focus Groups;Foundations;Friendships;Funding;Future;gaps in access;Goals;Health;health care delivery;health disparity;Health Personnel;HIV;Home;Human;implementation evaluation;implementation outcomes;implementation strategy;improved;innovation;insight;Intervention;Intervention Studies;Interview;Life;Maps;medical schools;meetings;Mental Depression;Mental disorders;Mental Health;Mental Health Services;mental set;Mentored Research Scientist Development Award;Mentors;Mentorship;Methodology;Methods;multidisciplinary;National Institute of Mental Health;Outcome;Participant;Patient-Focused Outcomes;Patients;Persons;physical conditioning;pilot test;pilot trial;preference;Prevention;Problem Solving;problem solving therapy;Process;programs;Protocols documentation;Provider;Province;Psyche structure;Public Health;Quality of life;Randomized;randomized trial;referral services;Research;Research Personnel;Resource-limited setting;Resources;response;Risk;scale up;Science;screening;Seasons;Services;Site;skills;South Africa;South African;Specific qualifier value;Time;tool;Training;treatment as usual;Treatment Efficacy;Treatment outcome;treatment response;Universities;Variant;Viral;Washington;Work

PROJECT_TITLE: Designing adaptive implementation strategies for mental health care in persons living with HIV in South Africa (DASH-SA)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 SCIL-A (03)]


ADMINISTERING_IC: HL

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Assistive Technology;Atherosclerosis;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Kidney Disease

ORG_CITY: Houston

ORG_NAME: VENOSTENT, INC.

ORG_STATE: TX

PHR: Project Narrative Hemodialysis (HD) is the primary mode of survival for half a million Americans with failed kidneys (i.e. stage 5 chronic kidney disease (CKD) or end-stage renal disease (ESRD); millions more globally die each year because they lack access to dialysis. Arteriovenous fistulas (AVFs), or surgical connections of veins to arteries in the arm, are considered the gold standard for HD treatment, but 39% of the AVFs created in the United States fail to ever be used for dialysis and 50% are abandoned within 12 months because the vein that connects to the artery maladapts, greatly contributing to 1- and 5-year HD mortality rates of 21% and 60%, respectively. To address this, VenoStent has developed the SelfWrap Bioabsorbable Perivascular Wrap, a wrap that helps the vein adapt favorably to its new high pressure, high flow AVF environment, thereby improving the quality and length of life of CKD patients and potentially millions of others undergoing similar vascular surgeries.

PI_NAMEs: BOIRE, TIMOTHY C (contact)

PROGRAM_OFFICER_NAME: FENTON, KATHLEEN NELLE

PROJECT_TERMS: Achievement;Address;Affect;American;Animal Model;arm;Arteries;Arteriovenous fistula;arteriovenous graft;Award;Blinded;Blood;Blood flow;Blood Vessels;Breakthrough device;Bypass;Cannulations;Cardiovascular Diseases;Cardiovascular system;Catheters;Cell Proliferation;Cessation of life;Chronic;Chronic Kidney Failure;Circulation;Clinical;Clinical Research;Coronary;Coronary Artery Bypass;Death Rate;Devices;Dialysis patients;Dialysis procedure;Disease;Effectiveness;effectiveness outcome;Elasticity;End stage renal failure;Endothelium;Environment;Event;Excision;Exposure to;Failure;FDA approved;Feasibility Studies;Female;Fistula;Food and Drug Administration Device Approval;Funding;Growth;Hemodialysis;Hour;Hyperplasia;improved;Infection;Injury;Institutional Review Boards;Intervention;Kidney;Legal patent;Life;Longevity;male;Mechanics;migration;Modeling;Morbidity - disease rate;mortality;Needles;Operative Surgical Procedures;Oryctolagus cuniculus;Participant;patient population;Patients;Peripheral;Phase;Physiological;Polymers;pre-clinical;pressure;primary outcome;prospective;Randomized;Safety;Sepsis;Sheep;Single-Blind Study;Small Business Innovation Research Grant;Small Business Technology Transfer Research;standard of care;success;Thick;Thinness;Time;Toxin;United States;United States National Institutes of Health;vascular smooth muscle cell migration;vascular smooth muscle cell proliferation;Veins;Venous

PROJECT_TITLE: SAVE-FistulaS: A Pivotal Study of SelfWrap-Assisted ArterioVEnous FistulaS

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 ISB-W (12)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Dementia;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Neurodegenerative;Neurosciences;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: RICHMOND

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: Abnormally phosphoryated Tau protein (pTau) is implicated as causative in Alzheimer's Disease and certain other cognitive disorders, and is also commonly observed in persons with cognitive changes in opioid use disorder (OUD) and in HIV/HAND. Both gain-of-function (AAV/Cre techniques) and loss-of-function (Tau knockout mice crossed to HAND models; Tau aggregation reduced pharmacologically) studies test the hypothesis that pTau production and aggregation cause/escalate cognitive dysfunction in OUD, in HIV/HAND, and to opiate-induced exacerbation of HAND. Neuron activity, pathology, biochemistry are measured in mice that are studied behaviorally so that direct correlations can be made; miniscopes are used to measure activity of individual hippocampal neurons over 12 weeks of behavioral testing.

PI_NAMEs: HAUSER, KURT F;KNAPP, PAMELA E (contact)

PROGRAM_OFFICER_NAME: BORGMANN, KATHLEEN RUTH

PROJECT_TERMS: abnormally phosphorylated tau;Affect;Alzheimer's Disease;Alzheimer's disease model;Amyloid;Animal Model;Area;Automobile Driving;Autopsy;awake;Behavior;behavior test;Behavioral;behavioral study;Biochemical;Biochemistry;biocytin;Blood;Brain region;brain tissue;Cell Physiology;Cells;clinically relevant;Cognition;Cognition Disorders;Cognitive;cognitive ability;cognitive change;Cognitive deficits;cognitive process;Color;comorbidity;Cre driver;Dementia;density;Deposition;design;Development;Disease;disease model;Drops;Electrophysiology (science);Exhibits;Exposure to;gain of function;Hippocampus;Histologic;HIV;HIV-associated neurocognitive disorder;Human;Hybrids;Image;Impaired cognition;improved;In Situ;Individual;Internal Ribosome Entry Site;Interneuron function;Interneurons;Knockout Mice;Link;Longitudinal Studies;loss of function;Measures;Modeling;Morphine;Morphology;Motor;motor disorder;mouse model;Mus;mutant;Naltrexone;Nerve Degeneration;neuroAIDS;Neurobehavioral Manifestations;Neuronal Dysfunction;Neurons;Opioid;Opioid Receptor;opioid use disorder;Outcome;Output;patch clamp;Pathologic;Pathology;Persons;Pharmaceutical Preparations;pharmacologic;Phase III Clinical Trials;phase III trial;Physiological;Physiology;Preparation;presynaptic;Process;Production;Property;protein expression;protein function;Proteins;Publishing;Pyramidal Cells;Reporter;Role;sex;Slice;symptomatology;Symptoms;System;tau aggregation;tau Proteins;tau-1;Tauopathies;Techniques;Testing;Time;Tissues;Transgenic Model;Transgenic Organisms;Vertebral column;Viral;Work

PROJECT_TITLE: pTau-related neuron and cognitive dysfunction in opioid-HIV comorbidity: Longitudinal and functional studies


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Brain Disorders;Cardiovascular;Clinical Research;Diabetes;HIV/AIDS;Infectious Diseases;Neurosciences;Pediatric;Pediatric - AIDS;Prevention

ORG_CITY: INDIANAPOLIS

ORG_DEPT: PEDIATRICS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Project Narrative With antiretroviral treatment (ART), children living with perinatal HIV achieve viral suppression, but inflammation persists, and may lead to early onset cardiovascular, metabolic and neurocognitive disorders. The goal of this study is to determine the durability of inflammation in persons with perinatal HIV after prolonged ART, its pathogenesis and the clinical consequences of sustained inflammation in a 10 year follow up study of the Pediatric Immune Activation cohort. Understanding long-term outcomes for the 2.7 million children living with HIV globally is of important public health relevance in order to develop early screening biomarkers and preventative interventions so they can thrive as adults.

PI_NAMEs: KHAITAN, ALKA  (contact)

PROGRAM_OFFICER_NAME: MAJJI, SAI PRASANNA

PROJECT_TERMS: 13 year old;Adolescence;Adult;Affect;Africa South of the Sahara;Age;age effect;Age related comorbidities;antiretroviral therapy;arterial tonometry;Beta Cell;Biological Markers;Biological Response Modifiers;Blood Pressure;C-Peptide;Cardiac;cardiometabolism;Cardiovascular Diseases;Cardiovascular system;Caring;Cell Physiology;Cells;Cellular Stress;Child;Childhood;Chronic;Clinical;Clinical Research;cohort;Cohort Studies;comorbidity;Competence;Cross-Sectional Studies;Development;early childhood;early onset;early screening;Echocardiography;EFRAC;endothelial dysfunction;Endothelium;Exposure to;FABP2 gene;Face;Fasting;fasting glucose;follow-up;Follow-Up Studies;GDF15 gene;Goals;Gut Mucosa;Health;HIV;HLA-DR Antigens;Hospitals;Immune;immune activation;immune health;Immunologic Markers;Immunologics;improved;Incidence;indexing;Infection;Inflammation;Inflammation Mediators;Inflammatory;inflammatory marker;Insulin;Insulin Resistance;Interleukin-6;Intestinal permeability;Kenya;Knowledge;Leadership;Life Expectancy;Link;Lipids;Measures;Metabolic;Metabolic Diseases;microbial;Modeling;monocyte;multidisciplinary;Myocardial;Neurocognitive;neurocognitive disorder;Neurologic;Neuropsychology;Outcome;Pathogenesis;Pathogenicity;Pathologic;perinatal HIV;Peripheral;Persons;Plasma;preventive intervention;Proinsulin;public health relevance;reactive hyperemia;Reporting;Research;Risk;Role;screening;sex;Structure of beta Cell of islet;T-Lymphocyte;Tablets;TNF gene;tool;Viral;Viral reservoir;Viremia;Virus;zonulin

PROJECT_TITLE: Long-term clinical and immunologic consequences of inflammation in perinatal HIV


FUNDING_MECHANISM: OTHERS

PHR: Project Narrative My current research is focused on understanding molecular mechanisms and pathophysiology that may be at the basis of stress-induced mood disorders, including depression, anxiety, and other neuropsychiatric disorders, and their influence on cognitive dysfunction and neurodegenerative disorders. These studies are investigating the role of psychological stress and toxin exposures in influencing novel neuro-inflammatory mechanisms driving immune-brain interactions to test causal hypotheses regarding neurovascular damage and the active recruitment of peripheral immune signals related to neuropathology and mood-related brain structures which control depression-like behavior, cognitive functioning, and neurodegeneration. The outcomes aim to further characterize and develop targeted therapeutics for conditions that severely impact the veteran population.

PI_NAMEs: PASINETTI, GIULIO MARIA (contact)

PROJECT_TERMS: Acceleration;Address;Adult;aging process;Alzheimer's Disease;Alzheimer's disease related dementia;anti-depressive agents;Anxiety;Automobile Driving;Award;Basic Science;Behavior;Biological;Biomedical Research;blood-brain barrier permeabilization;Botanicals;Brain;career;Cells;Chronic;clinical center;clinical investigation;Clinical Trials;Cognitive;Cognitive deficits;cognitive disability;cognitive function;Collaborations;Complex;cytokine;Data;Dementia;Department of Defense;depression model;depression prevention;design;Development;Dietary Formulations;Dietary Polyphenol;dietary supplements;Disease;dosage;Dose;drug discovery;Drug Kinetics;Education;Elderly;Endowment;experience;Exposure to;Family;Fatigue;Flavonoids;forging;Frontotemporal Dementia;frontotemporal lobar dementia amyotrophic lateral sclerosis;Functional disorder;Funding;Future;Genomics;Geriatrics;Goals;Grant;Grapes;Gulf War;gut microbiome;Health;Human;human monoclonal antibodies;Immune;immune depression;immune modulating agents;Immune signaling;Immune system;Immune System Diseases;Immune Targeting;Immunotherapy;Impaired cognition;Impairment;improved;in vivo;indexing;Individual;Inflammation;Inflammation Mediators;Inflammatory;inflammatory marker;Inflammatory Response;Infrastructure;Innate Immune Response;insight;Investigation;Journals;Juice;Long-Term Effects;Manuscripts;Medical center;medical schools;Mental Depression;Mental health promotion;Microglia;military service;military veteran;Modeling;Molecular;Mood Disorders;Moods;mouse model;Natural Products;Nerve Degeneration;Nervous System Disorder;Neurodegenerative Disorders;neuroinflammation;Neurology;Neurons;neuropathology;neuropsychiatric disorder;Neurosciences;Neurotoxins;neurovascular injury;novel;novel therapeutics;Outcome;Pathogenesis;Pathway interactions;Peer Review;Peripheral;Persian Gulf Syndrome;Pharmaceutical Preparations;phase I trial;Physiological;Plasma;polyphenol;pre-clinical;preclinical study;Predisposition;Preparation;prevent;professor;programs;promote resilience;Psychiatry;psychologic;Psychological Stress;psychological trauma;Publications;Recruitment Activity;Research;resilience;resilience biomarker;response;Risk Factors;Role;Safety;Scientist;Seminal;Stress;Stressful Event;Structure;Symptoms;targeted treatment;Testing;Therapeutic;therapeutic evaluation;therapeutic target;Toxic Environmental Substances;Toxin;Training;translational study;Traumatic Brain Injury;United States Department of Veterans Affairs;United States National Institutes of Health;Up-Regulation;Validation;validation studies;Veterans

PROJECT_TITLE: BLR&D Research Career Scientist Award Application

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 RCSR-N (01)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;HIV/AIDS;Infectious Diseases;Mental Health;Mental Illness;Neurosciences;Pediatric;Pediatric - AIDS;Serious Mental Illness

ORG_DEPT: PSYCHIATRY

PHR: PROJECT NARRATIVE Chronic inflammation that persists in people with HIV is thought to impact the brain and elicit depressive behaviors, including motivational deficits like anhedonia that promote poor disease outcomes and are difficult to treat. The pathophysiologic mechanisms of HIV-associated CNS and behavioral dysfunction are not fully understood, but may involve peripheral blood monocytes and the cellular metabolic mechanisms that enable their activation and migration to the brain. The proposed research will examine monocyte glycolysis and migration as pathways to HIV-associated inflammation, reward circuit dysfunction, and symptoms of anhedonia while exploring immunomodulators that may therapeutically target monocyte mechanisms in HIV.

PI_NAMEs: BEKHBAT, MANDAKH  (contact)

PROGRAM_OFFICER_NAME: RAO, VASUDEV RAMACHANDRA

PROJECT_TERMS: Adherence;Anhedonia;Anti-Inflammatory Agents;antiretroviral therapy;Applications Grants;astrogliosis;Behavior;Behavioral;Behavioral Symptoms;Bioenergetics;Biological Assay;Biological Markers;Blood - brain barrier anatomy;Brain;Brain region;C-reactive protein;career;career development;cell motility;Cells;Cerebrospinal Fluid;chemokine;Chronic;Clinical;Clinical Research;Cognitive deficits;Corpus striatum structure;cytokine;Data;depressed patient;depression model;depressive behavior;depressive symptoms;design;Development;Disease Outcome;Drug Design;drug development;drug discovery;experience;Functional disorder;Functional Magnetic Resonance Imaging;Funding;Future;Genus Hippocampus;Glycolysis;Goals;HIV;HIV Seronegativity;Human;Immune;Immunomodulators;immunomodulatory therapies;immunoregulation;Impairment;In Vitro;Inflammation;Inflammatory;inflammatory marker;Inflammatory Response;inhibitor;innovation;Measures;Medial;Medical;Mental Depression;Mental disorders;Mentors;Mentorship;Metabolic;Metabolism;Microglia;migration;monocyte;Motivation;Myeloid Cells;National Institute of Mental Health;Neurocognitive Deficit;neuroimaging;Neuroimmune;neuroinflammation;neuropsychiatric symptom;neuropsychiatry;novel;novel strategies;Nutrient;Outcome;Parents;Pathology Report;Pathway interactions;Patients;Peripheral;Peripheral Blood Involvement;Persons;Pharmaceutical Preparations;Placebos;Plasma;Pre-Clinical Model;Process;programs;psychiatric comorbidity;psychiatric symptom;Psychiatric therapeutic procedure;Psychiatry;Research;research and development;Resources;Rest;reward circuitry;reward dysfunction;reward processing;Rewards;Role;Signal Transduction;symptom cluster;Symptoms;Testing;Therapeutic;therapeutic target;trafficking;Training;translational approach;treatment strategy

PROJECT_TITLE: The role of monocyte metabolism and migration in inflammation-related reward circuit deficits and symptoms of anhedonia in people with HIV


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Emergency Care;HIV/AIDS;Health Services;Infectious Diseases;Mental Health;Pediatric;Pediatric - AIDS;Prevention;Sexually Transmitted Infections

ORG_CITY: NEW YORK

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: PROJECT NARRATIVE Dr. Solnick's K23 research addresses critical gaps in HIV prevention and care by developing, implementing, and testing the Telephone Initiated PrEP Post-Emergency Department Discharge (TIPPED) protocol, a comprehensive and pragmatic approach for initiating PrEP in STI-diagnosed patients who visit Emergency Departments. Using implementation science methodology, stakeholder engagement, interrupted time series analysis, and a nested pilot RCT, this study will evaluate the implementation of a novel TIPPED protocol as well as a persuasive health communication intervention (PHCI) and ultimately improve PrEP initiation rates for patients at risk of HIV. This research will not only deliver important implementation science and clinical findings but also lay the foundation for larger-scale implementation and study across multiple emergency departments.

PI_NAMEs: SOLNICK, RACHEL EMILY (contact)

PROJECT_TERMS: Accident and Emergency department;Address;Adherence;Administrator;AIDS prevention;Ally;Appointment;Behavior Therapy;Callback;career development;Caring;Clinic;Clinical;clinical care;clinical outcome assessment;Clinical Trials Design;Communicable Diseases;Consolidated Framework for Implementation Research;Continuity of Patient Care;Counseling;Data;Development Plans;Diagnosis;Educational Intervention;electronic health data;Electronic Health Record;Eligibility Determination;Emergency Department patient;Emergency department visit;Emergency Medicine;Ensure;Epidemic;experience;Face;follow-up;Foundations;Future;health care availability;health communication;Health system;Healthcare;HIV;HIV Infections;HIV risk;HIV/AIDS;HIV/HCV;implementation determinants;implementation evaluation;implementation science;implementation strategy;improved;improved outcome;Individual;innovation;Interdisciplinary Study;Interruption;Intervention;Interview;Knowledge;Laboratories;Link;Maintenance;Maps;Measures;medication compliance;Mentors;Mentorship;Methodology;Methods;Modeling;novel;Outcome;Outpatients;Participant;patient engagement;Patient Participation;patient-level barriers;Patients;Physician Assistants;Physicians;pilot test;pre-exposure prophylaxis;prevent;Principal Investigator;Procedures;Process;protocol development;Protocols documentation;provider-level barriers;Public Health;Publishing;Radiology Specialty;Randomized;Randomized, Controlled Trials;Recommendation;Research;research and development;Research Personnel;Research Project Grants;Resources;Risk;Risk Factors;Role;Scientist;Series;sexual health intervention;Sexually Transmitted Diseases;Site;Statistical Data Interpretation;Statistical Methods;success;Surveys;system-level barriers;Telephone;Test Result;Testing;Time;Time Series Analysis;tool;trial design;United States;uptake;Washington;Work

PROJECT_TITLE: Telephone Initiated PrEP Post-ED Discharge (TIPPED)


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Mental Health;Pediatric;Pediatric - AIDS;Prevention;Rare Diseases;Sexually Transmitted Infections;Social Determinants of Health;Women's Health Research

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: NARRATIVE In South Africa (SA), as many as 45.5% of transgender women (TW) may be living with HIV, and an estimated 1/3 are not in care; estimates of prevention behaviors, such as HIV testing, and pre-exposure prophylaxis (PrEP) use are also low (20.5% and 11%, respectively) and prevalence of syphilis, which drastically increases HIV risk and viral load, is ~9%. This study uses the Mensch Model to fill 3 critical information domains necessary to develop a dual HIV/syphilis (via INSTI Multiplex) self-testing and linkage-to-care intervention for SA TW, including needs/preferences on: self-test access/uptake, logistical support to use/interpret tests, and linkage to and uptake of PrEP and/or HIV/syphilis treatment. In 3 stages, we will: 1) conduct in-depth interviews (IDIs) with SA TW (N=15), and healthcare workers who care for SA TW (HCW; N=15) to understand preferences on the domains (Stage 1); send web-based surveys to SA TW's mobile phones (N=80), to identify the most popular strategies address each domain, and converge qualitative and quantitative data to draft the intervention using the 4 COM-B Intervention Function Matrix (Stage 2); and 3) convene an intervention development workgroup consisting of at least n=5 members from each our CAB, TW, and HCW groups (total of at least N=15 workgroup group participants) to further develop/refine the intervention to be pilot tested in a future R34 (Stage 3).

PI_NAMEs: RAEL, CHRISTINE TAGLIAFERRI (contact)

PROGRAM_OFFICER_NAME: GREENWOOD, GREGORY LOUIS

PROJECT_TERMS: Address;Adoption;Affect;Africa South of the Sahara;AIDS prevention;Appointment;Awareness;Behavior;Blood;Caring;Cellular Phone;Clinic;clinical center;clinical research site;Collaborations;Communities;community advisory board;cost;Cost Savings;Country;Data;Discrimination;Economics;effective intervention;Employment;Enrollment;Ensure;Epidemic;experience;Exploratory/Developmental Grant;Face;Feedback;Funding;Future;gender diverse;General Population;Health;Health Personnel;Health system;high risk;HIV;HIV risk;Home;Housing;Human immunodeficiency virus test;improved;Incidence;Infrastructure;Institution;Instruction;Intervention;intervention refinement;Interview;Knowledge;Life;Link;marginalization;Medical;medical specialties;meetings;member;Methods;Modeling;observational cohort study;Online Systems;Outcome;Package Insert;Participant;peer;Persons;pilot test;Policy Maker;Population;pre-exposure prophylaxis;preference;Prevalence;Prevention;prevention service;Privacy;Process;Public Health;recruit;Research;response;Risk;scale up;Screening procedure;Self Administration;self testing;Services;Sexual and Gender Minorities;sexual and reproductive health;Site;social;social determinants;social stigma;South Africa;South African;Surveys;Syphilis;Syphilis Serodiagnosis;telehealth;Testing;testing access;testing uptake;Text;therapy development;transgender;transgender women;transphobia;treatment services;uptake;Viral Load result;Vulnerable Populations;Wit;Work

PROJECT_TITLE: Formative work for the development of an intervention to support combined HIV/syphilis self-testing and linkage to prevention and treatment services for transgender women in South Africa


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Clinical Research;Genetics;HIV/AIDS;Human Genome;Infectious Diseases;Neurosciences

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Narrative Up to half of people with HIV (PWH) develop HIV-associated neurocognitive disorders (HAND), even on effective antiretroviral therapy (ART). Little is known about the pathologic mechanism behind this group of disorders, including what exact role the virus plays in its their development. Using tissues from the unique Last Gift cohort, we will examine the epigenetic context of the integrated provirus guiding HIV expression in microglia, which are the primary reservoir for HIV in the brain. We will also examine the inflammatory cells in the brains in PWH on effective ART using cutting edge single cell sequencing techniques

PI_NAMEs: LAMERE, SARAH ADRIANNE (contact)

PROGRAM_OFFICER_NAME: DALEY, WILLIAM PATRICK

PROJECT_TERMS: Affect;Agonist;antiretroviral therapy;Astrocytes;Autopsy;Basal Ganglia;Brain;brain tissue;CD4 Positive T Lymphocytes;cell immortalization;Cell Line;Cell Separation;cell type;Cells;Cellular Assay;Characteristics;Chromatin;Chromatin Remodeling Factor;Chronic;Clinical;cohort;Cohort Studies;Data;Deposition;Development;Disease;DNA Methylation;Environment;Epigenetic Process;epigenetic profiling;epigenetic regulation;epigenetic silencing;epigenomics;Evaluation;EZH2 gene;frontal lobe;Generations;Genetic Transcription;Gifts;Goals;histone modification;HIV;HIV Infections;HIV-1;HIV-associated neurocognitive disorder;Human;Immune;In Vitro;Inflammation;Inflammatory;inflammatory milieu;inhibitor;integration site;Knowledge;Length;lonely individuals;Mediator;member;Methods;Microglia;Modality;Modernization;Modification;Myeloid Cells;Neurocognitive Deficit;Neurodegenerative Disorders;neuroinflammation;Neurons;novel;NR4A2 gene;Nucleic Acids;Participant;Pathogenesis;Pathologic;Peripheral;Persons;Phenotype;Play;Population;preservation;Process;prospective;Provirus Integration;Proviruses;receptor;Role;Severities;single cell ATAC-seq;single cell sequencing;single nucleus RNA-sequencing;Sorting;Techniques;therapy development;Tissue Sample;Tissues;transcriptomics;transmission process;Viral Proteins;viral RNA;Virus;Virus Replication;Work

PROJECT_TITLE: Epigenetic profiling of HIV-associated neuroinflammation and proviral expression in the brain

STUDY_SECTION: HVCD

STUDY_SECTION_NAME: HIV Molecular Virology, Cell Biology, and Drug Development Study Section[HVCD]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

ORG_CITY: PEMBROKE PINES

ORG_NAME: ENGINEERING RESOURCES GROUP, INC.

PHR: PROJECT NARRATIVE DNA damage, caused by environmental agents and the body’s normal processes, plays a critical role in the development of many major human diseases; in the U.S. alone, this potentially impacts one in two adults (~125 million people). While the comet assay is one of the most widely used and versatile methods for detecting cellular DNA damage, it is a time-consuming and labor intensive method. This proposal aims to develop a novel device for automating the comet assay, facilitating the simple and rapid measurement of DNA damage; advancing our knowledge of the role of DNA damage in health and disease, and hence promoting mitigation strategies and therapeutic interventions.

PI_NAMEs: COOKE, MARCUS STANLEY;ROSS, CHRISTOPHER  (contact)

PROGRAM_OFFICER_NAME: SHAUGHNESSY, DANIEL

PROJECT_TERMS: Academia;Acceleration;Address;Adoption;Adult;Advanced Development;Aging;assessment application;authority;Authorization documentation;automated analysis;Automation;Award;Behavior;Benchmarking;Biological Assay;Biological Models;biomarker development;Buffers;Cardiovascular Diseases;Cell Line;Cells;Chemicals;Collection;Comet Assay;commercialization readiness;Computer software;Consumption;cost;Custom;detection method;Development;Devices;digital;disability;Disease;DNA;DNA Damage;Documentation;Drainage procedure;Economics;Engineering;environmental agent;European;Evaluation;Exposure to;flexibility;Florida;Food Safety;Gel;Genomic Instability;Goals;good laboratory practice;Guidelines;Hand;Health;HepG2;high volume manufacturing;Human;human disease;improved;Individual;Industrialization;Industry;Instruction;instrument;International;Knowledge;Laboratories;Laboratory Research;Legal patent;Life;Life Cycle Stages;Link;Malignant Neoplasms;manufacture;Marketing;Measurement;Measures;Medicine;Methods;Mission;Modification;National Institute of Environmental Health Sciences;National Toxicology Program;Nature;Nerve Degeneration;novel;operation;Organism;Outcome;Pathogenesis;Performance;Persons;Pharmacologic Substance;Phase;Play;Procedures;Process;Production;programs;prototype;Public Health;Reagent;Recommendation;Recording of previous events;Regulation;Reproducibility;Resources;Risk;Risk Assessment;Risk Factors;Role;Running;Sampling;scale up;Science;screening;screening guidelines;Slide;Small Business Technology Transfer Research;Source;Stains;supply chain;symposium;System;Technology;Testing;Therapeutic Intervention;three-dimensional modeling;Time;Toxicity Tests;Toxicology;United States National Institutes of Health;Universities;Validation;Variant;wasting;Work

PROJECT_TITLE: An automated device for quantifying DNA damage

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-G (15)]


PHR: For over a decade, Dr. Stella Dracheva's research has focused on deciphering the molecular underpinnings of brain disorders prevalent among U.S. military Veterans. Her work encompasses psychiatric and neurological disorders such as major depressive disorder, suicide, schizophrenia, opioid addiction, as well as amyotrophic lateral sclerosis and spinal cord injury. Current treatments for these conditions are limited and often ineffective for many patients, underlining the urgent need for a deeper biological understanding to facilitate novel therapeutic development. Dr. Dracheva's track record of federal funding and impactful publications in high-ranking journals demonstrate her substantial contributions to these research areas. The RCS Award will enhance Dr. Dracheva's VA research, fostering new investigations, collaborations, and mentorship opportunities.

PI_NAMEs: DRACHEVA, STELLA  (contact)

PROJECT_TERMS: Acceleration;Address;Adopted;Advanced Development;Amyotrophic Lateral Sclerosis;Animal Model;Applications Grants;Appointment;Area;Autopsy;Award;Biological;Bipolar Disorder;Brain;brain cell;Brain Diseases;Brain region;C9ORF72;career;causal variant;cell type;Cells;Central Nervous System Diseases;Collaborations;Communication;Communities;Complex;Comprehension;Data;Data Set;data sharing;Disease;DNA;DNA Modification Process;editorial;Epigenetic Process;epigenetic regulation;epigenetic variation;epigenomics;Evolution;Exhibits;Extramural Activities;Fostering;Foundations;frontier;frontotemporal lobar dementia amyotrophic lateral sclerosis;Functional disorder;Funding;Gene Expression;General Population;Genes;Genetic;Genetic Risk;Genetic Transcription;Genomics;Grant;Histones;Human;human disease;Incentives;Incidence;inhibitory neuron;innovation;insight;Interdisciplinary Study;Investigation;Journals;Laboratories;Major Depressive Disorder;member;Mental disorders;Mentorship;Methodology;Methods;Methylation;Microglia;military service;military veteran;Molecular;Molecular Biology;molecular marker;mortality;multidisciplinary;Mutation;Nature;Nerve Degeneration;Nervous System Disorder;Neurobiology;neurodevelopment;Neuroglia;neuron development;Neurons;Neurosciences;novel;novel therapeutics;Opiate Addiction;opioid overdose;Paper;patient subsets;Patients;Pattern;Pharmaceutical Preparations;Post-Traumatic Stress Disorders;prevent;Principal Investigator;Psychiatry;Publications;Regulatory Element;Reporting;Research;Research Personnel;risk variant;Role;Schizophrenia;Science;Scientist;Spinal cord injury;Stream;Suicide;suicide brain;suicide rate;suicide victim;System;therapeutic development;therapeutic target;Tissues;Training;transcriptomics;United States National Institutes of Health;Untranslated RNA;Veterans;Work


ORG_CITY: DURHAM

ORG_NAME: DURHAM VA MEDICAL CENTER

ORG_STATE: NC

PHR: The rate of suicide among Veterans increased by 57% from 2001 to 2019; however, prospective prediction of suicidal behaviors remains a major challenge. Moreover, whereas heritability estimates for suicidal thoughts and behaviors range from 30-55%, the genetic basis of suicide remains largely unknown. Dr. Kimbrel’s program of research aims to address these gaps and to promote a precision medicine-based approach to suicide prevention in Veterans by: (1) Identifying the genetic, epigenetic, and environmental factors that underlie risk for suicide and other closely-related conditions in Veterans; (2) Developing improved risk algorithms that utilize state-of-the-art machine learning techniques and novel data sources to identify Veterans at risk for suicide; and (3) Creating practical clinical tools that enhance clinicians’ ability to identify and intervene with Veterans at risk for attempting suicide.

PI_NAMEs: KIMBREL, NATHAN A. (contact)

PROJECT_TERMS: Acute;Address;aging related;alcohol misuse;Algorithms;Altitude;American;Area;Area Under Curve;artificial intelligence method;artificial intelligence model;authority;Award;Behavioral Sciences;Biography;Biological Aging;Biological Psychiatry;Book Chapters;Books;career;Childhood;Clinical;Clinical Trials;cohort;combat;Communication;Data;Data Sources;deep neural network;Department of Energy;Development;DNA Methylation;DRD2 gene;Ecological momentary assessment;Electronic Health Record;Environment;Environmental Risk Factor;Epigenetic Process;epigenome-wide association studies;ESR1 gene;evidence base;experience;Feeling suicidal;functional outcomes;Funding;gene environment interaction;Gene Expression;Genes;Genetic;genetic epidemiology;Genetic Risk;genetic risk factor;Genetic study;genome wide association study;genome-wide;Genomics;Grant;Grant Review;Health Sciences;Healthcare;Heritability;Hippocampus;improved;indexing;Individual;International;Interpersonal Violence;Intervention;Investigation;journal article;Journals;Laboratories;Machine Learning;marijuana use;Measures;Medicine;Mental Depression;Mental Health;Mentors;Methods;mid-career faculty;Military Personnel;Modeling;Molecular;mortality;Names;Natural Language Processing;Nature;Neural Network Simulation;next generation;non-suicidal self injury;novel;Participant;Pathogenesis;Peer Review;Persian Gulf Syndrome;phenomenological models;Phenotype;Play;Post-Traumatic Stress Disorders;precision medicine;Predictive Value;Prevalence;Prevention;programs;prospective;Psychiatry;psychogenetics;Psychopathology;Publications;Publishing;Research;Research Methodology;Research Personnel;Risk;Risk Factors;risk prediction;risk variant;Role;rurality;Science;Scientist;sexual trauma;social deprivation;Statistical Models;Stressful Event;Substance abuse problem;Substance Use Disorder;suicidal behavior;suicidal morbidity;suicidal risk;Suicide;Suicide attempt;Suicide prevention;suicide rate;Surface;Techniques;Testing;Thick;Time;TNF receptor-associated factor 3;tool;Training;Translating;traumatic stress;Validation;Veterans;Work

PROJECT_TITLE: BLRD Research Career Scientist Award Application


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Biotechnology;Cancer;Gene Therapy;Genetics;HIV/AIDS;Human Fetal Tissue;Immunotherapy;Infectious Diseases

ORG_CITY: LOS ANGELES

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE We propose to develop an in vivo approach to therapeutic T-cell transformation that exploits our ability to synthesize virus-like particles (VLPs) from purified mRNA and viral capsid protein and to functionalize these particles with targeting antibodies against proteins that are uniquely expressed in T cells. The mRNA that is delivered in this way encodes either a T-cell receptor (TCR) or a chimeric-antigen receptor (CAR) that is specific to the particular cancer or viral infection from which a patient is suffering. The goal of this in vivo transformation and its accompanying transient expression of TCR and CAR genes is to supplant current ex vivo immunotherapies with ones that avoid both the extraction/infusion of T cells and the disruption of T-cell chromosomes by permanent integration of new genes.

PI_NAMEs: GELBART, WILLIAM M (contact);YANG, OTTO O

PROGRAM_OFFICER_NAME: ZHOU, YAN

PROJECT_TERMS: Antibodies;Antigens;Back;Biological Assay;Biology of HIV Infection;Biotinylation;Blood;Cancerous;Capsid Proteins;CD3 Antigens;CD8-Positive T-Lymphocytes;CD8B1 gene;cell killing;cell transformation;Cells;Chemistry;chimeric antibody;chimeric antigen receptor;chimeric antigen receptor T cells;Chromium;Chromosomes;cost;Cytoplasmic Tail;cytotoxic;Dependence;DNA;Electron Microscopy;Electroporation;Esters;Flow Cytometry;gel electrophoresis;Genes;Glycoproteins;Goals;Growth;Hematopoietic stem cells;HIV;HIV Antigens;HIV therapy;Human;humanized mouse;IgG4;Immune;Immune system;Immunotherapy;In Vitro;in vivo;Incubated;Infusion procedures;Lead;Lentivirus Vector;Ligands;Lymphatic System;Malignant Neoplasms;Measures;Mediating;Membrane;Messenger RNA;Methodology;Monoclonal Antibody HuM291;mouse model;Mus;Negative Staining;Neoplasm Metastasis;neutralizing antibody;Occupations;particle;Patients;Plant Viruses;Procedures;Proteins;Protocols documentation;Publishing;receptor;receptor expression;Receptor Gene;reconstitution;Reporting;Resistance;Ribonucleases;Risk;RNA Sequences;self assembly;Streptavidin;Surface;T cell therapy;T-Cell Receptor;T-Cell Transformation;T-Lymphocyte;Tissues;Translations;Tumor Antigens;tumorigenesis;Viral;Virus;Virus Assembly;Virus Diseases;Virus Replication;Virus-like particle;Western Blotting;Work

PROJECT_TITLE: In vivo CAR-T-cell HIV therapy using in vitro reconstituted virus-like particles


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: SAN DIEGO

ORG_NAME: SAN DIEGO STATE UNIVERSITY

PHR: PROJECT NARRATIVE In fishing communities in eastern Africa and similar environments alcohol and HIV are intertwined epidemics creating challenges to optimizing HIV treatment as prevention and ending the HIV epidemic. We propose to test an intervention and its components to reduce heavy alcohol use and improve ART adherence and HIV treatment outcomes with promising preliminary efficacy in this setting. We will also explore barriers and facilitators of integrating the intervention into routine clinical care to inform future widespread implementation.

PI_NAMEs: KIENE, SUSAN MARIA (contact);MATOVU, JOSEPH KB

PROGRAM_OFFICER_NAME: FREEMAN, ROBERT

PROJECT_TERMS: Address;Adherence;Affect;Alcohol abuse;alcohol availability;Alcohol consumption;alcohol intervention;alcohol screening;Alcohols;Anti-Retroviral Agents;Area;arm;behavior change;Behavior Therapy;behavioral and social science;behavioral economics;Biological Markers;brief intervention;Caring;Chronic;Clinic;Clinical;clinical care;Communities;comorbidity;Counseling;depressive symptoms;Dimensions;discounting;Documentation;drinking;Eastern Africa;efficacy evaluation;Elements;Ensure;Environment;Epidemic;evidence base;Evidence based intervention;Exploration, Preparation, Implementation, and Sustainment;Fishes;follow-up;food security;Future;future implementation;General Population;Goals;hazardous drinking;Health;Health Services Accessibility;Heavy Drinking;high risk population;HIV;HIV/AIDS;implementation cost;implementation facilitators;implementation research;implementation science;implementation strategy;improved;Incidence;interest;Intervention;intervention cost;intervention effect;Link;Measures;Mediating;Mediator;men;Methods;Motivation;motivational enhancement therapy;Operations Research;optimal treatments;Outcome;Outcome Assessment;Personal Satisfaction;Persons;phosphatidylethanol;physical conditioning;Policies;Prevalence;Prevention Research;primary outcome;protective effect;psychologic;Psychological reinforcement;Randomized;Randomized, Controlled Trials;Research;Rewards;Risk;Risk Behaviors;Sampling;Savings;scale up;screening;socioeconomics;synergism;Testing;treatment as prevention;Treatment Efficacy;treatment optimization;Treatment outcome;Uganda;United States National Institutes of Health;Viral Load result;Work

PROJECT_TITLE: Reducing hazardous alcohol use and optimizing treatment as prevention among men living with HIV in risk environments


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Pediatric;Pediatric - AIDS;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

PHR: PROJECT NARRATIVE Black women with BW face sociostructural inequities including structural racism, HIV stigma, and medical mistrust in addition to the syndemic effects of substance use, intimate partner violence and adverse mental health, which act as barriers to health seeing behaviors that contribute to poor HIV outcomes. Additionally, BW have been historically under enrolled in HIV clinical research that does not contend with these historical circumstances. As a first-generation, Black female predoctoral student, this explanatory sequential mixed methods R36 dissertation proposal is the first to attempt to quantify and contextualize the impacts of sociostructural inequities and syndemics on BW’s participation in HIV research to inform multilevel intervention efforts to conduct equitable and diverse research.

PI_NAMEs: CAMPBELL, DANIELLE M (contact)

PROGRAM_OFFICER_NAME: KAMATH, SUSANNAH M A

PROJECT_TERMS: Address;Affect;Agreement;AIDS clinical trial group;Amphetamines;Area;Attention;Behavior;behavioral study;Biological;Black Populations;Black race;black women;California;care seeking;Caring;Child Care;Clinical;Clinical Research;clinical research site;Clinical Trials Cooperative Group;Clinical Trials Network;Cocaine;Communities;community organizations;Community Outreach;Contraceptive methods;Control Groups;curative treatments;Data;depressive symptoms;design;Disparity;doctoral student;Enrollment;Ensure;Epidemic;Equity;ethnic minority population;Exclusion;experience;Face;Gender;Generations;Goals;Grant;Health;health inequalities;health literacy;health seeking behavior;HIV;HIV diagnosis;HIV Vaccine Trials Network;Hour;Human Resources;improved;Inequity;Infrastructure;Institution;Interpersonal Violence;intersectionality;Intervention;Interview;intimate partner violence;Investigation;Literacy Programs;Medical;medication compliance;member;Menstruation;Mental Depression;Mental Health;Mentors;Methods;mHealth;minority scientist;Oklahoma;Outcome;Paint;Participant;peer;Perception;Pharmaceutical Preparations;Policies;Post-Traumatic Stress Disorders;pre-doctoral;Pregnancy;Prevalence;Prevention;Process;programs;Provider;Race;racial minority population;racism;Recording of previous events;recruit;Reporting;reproductive;Research;Research Design;research study;response;Risk;Role;Sampling;Scientific Advances and Accomplishments;Site;social;Social Behavior;social stigma;social structure;Source;Strategic Planning;structural determinants;Structural Racism;Structure;study population;substance use;Surveys;syndemic;System;theories;Underrepresented Minority;United States;United States National Institutes of Health;Vaccines;Viral;Voice;willingness;Woman

PROJECT_TITLE: The Effects of Structural Inequities and Syndemics on Willingness to Participate in HIV Research among Black Women

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F17B-H (20)]


ADMINISTERING_IC: OD

ED_INST_TYPE: PRIMATE CENTERS

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

ORG_CITY: DAVIS

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Overall Narrative The CNPRC has a long history in the production of pedigreed SPF rhesus macaques. The goal of this application is to continue and expand on the improvement and characterization of the model through a program of viral screening, genetic testing, and characterization of the enteric microbiome.

PI_NAMEs: ROBERTS, JEFFREY A (contact);TIMMEL, GREGORY BRION

PROGRAM_OFFICER_NAME: SUI, YONGJUN

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Adult;animal resource;Animals;biobank;Biological Assay;Breeding;California;Censuses;Collection;COVID-19 surveillance;Cytomegalovirus;Data;Data Analyses;detection test;Development;Diagnostic;diagnostic assay;Diagnostic tests;fecal microbiome;flexibility;gastrointestinal;Genetic;genetic analysis;genetic pedigree;Genetic Services;genetic testing;Geography;Goals;gut microbiome;Haplotypes;HIV;HIV Infections;HIV/AIDS;host microbiome;Immune response;Immune system;improved;Inflammation;instrument;Knowledge;Laboratories;Light;Lymphoid Cell;Macaca mulatta;Maintenance;Major Histocompatibility Complex;Modeling;novel;novel diagnostics;Parasitic infection;pathogen;peripheral blood;Peripheral Blood Lymphocyte;pilot test;Population;Population Genetics;Primates;Production;programs;Recording of previous events;Reproducibility;Research;Research Design;Research Personnel;Research Project Grants;Resources;respiratory;Rhadinovirus;Rhesus;Sampling;screening;Simian Foamy Virus;Simian Retroviruses;simian T cell lymphotrophic virus;SIV;Testing;testing services;Trypanosoma cruzi;Tuberculosis;Viral;virology;Virus;Wisconsin;Work

PROJECT_TITLE: Production of Pedigreed SPF Rhesus Macaques

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 EMS-H (55)]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;HIV/AIDS;Infectious Diseases;Microbiome

PI_NAMEs: TIMMEL, GREGORY BRION (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Adult;Animals;biobank;Biological Assay;Breeding;California;Censuses;Collection;COVID-19 surveillance;Cytomegalovirus;detection test;fecal microbiome;flexibility;genetic analysis;genetic pedigree;Geography;Goals;gut microbiome;HIV;HIV Infections;HIV/AIDS;host microbiome;Immune response;Immune system;improved;Inflammation;Lymphoid Cell;Macaca mulatta;Maintenance;Major Histocompatibility Complex;Modeling;Parasitic infection;pathogen;peripheral blood;Peripheral Blood Lymphocyte;Population;Primates;Production;Research;Research Personnel;Research Project Grants;Resources;Rhadinovirus;Rhesus;Sampling;screening;Simian Foamy Virus;Simian Retroviruses;simian T cell lymphotrophic virus;SIV;Testing;Trypanosoma cruzi;Tuberculosis;Virus;Work

PROJECT_TITLE: Husbandry & Management Core


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Coronaviruses;Coronaviruses Diagnostics and Prognostics;Emerging Infectious Diseases;Genetics;HIV/AIDS;Infectious Diseases;Microbiome

PI_NAMEs: VAN ROMPAY, KOEN K (contact)

PROJECT_TERMS: Algorithms;Alleles;biobank;Biological Assay;Collection;COVID-19 assay;COVID-19 surveillance;COVID-19 testing;Cytomegalovirus;Data;detection test;Development;diagnostic assay;Diagnostic tests;genetic pedigree;Goals;HIV;host microbiome;Immune system;improved;Knowledge;Laboratories;Lymphocyte;Macaca mulatta;Maintenance;microbiome;Modeling;novel;novel diagnostics;Population;Primates;Production;Reagent;Research Project Grants;Rhadinovirus;Rhesus;routine screening;Sampling;screening;screening panel;Simian Foamy Virus;Simian Retroviruses;simian T cell lymphotrophic virus;SIV;Testing;testing services;Tuberculosis;Virus;virus testing;Work

PROJECT_TITLE: Viral Testing Core


PI_NAMEs: ROBERTS, JEFFREY A (contact)

PROJECT_TERMS: Adult;Alleles;Animals;biobank;Biological Assay;Breeding;complex data;Cytomegalovirus;Ensure;Exhibits;Founder Effect;Generations;Genetic;genetic analysis;Genetic Drift;Genetic Heterogeneity;genetic pedigree;Genetic Services;genetic variant;Genetic Variation;Genome;Genotype;Geography;Goals;Grant;gut microbiome;Haplotypes;Health;Heterozygote;HIV;host microbiome;Immune system;improved;Inbreeding;Individual;life history;Longevity;Macaca mulatta;Maintenance;Major Histocompatibility Complex;Migrant;Monitor;Parasitic infection;Peripheral Blood Lymphocyte;Population;Population Genetics;preservation;Production;Productivity;reproductive;Research;Research Personnel;Research Project Grants;Rhadinovirus;Rhesus;Risk;Sampling;screening;Simian Foamy Virus;Simian Retroviruses;SIV;T-Lymphocyte;Testing;Time;Trypanosoma cruzi;Tuberculosis;Virus;Work

PROJECT_TITLE: MHC Typing Core


NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Mental Health;Pediatric;Pediatric - AIDS;Post-Traumatic Stress Disorder (PTSD);Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: SAN FRANCISCO

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Given that transgender women face high levels of trauma (e.g., events that result in harmful effects), clarifying the mechanisms by which traumatic events and the mental health sequelae impact HIV prevention and HIV care engagement is needed. This proposed study will explore trauma, mental health, and trans women’s engagement in HIV prevention and HIV care, implement an evidence-based trauma intervention, and explore implementation outcomes. Findings from this study will inform a larger scale study that will implement the trauma-informed intervention across multiple clinics to improve HIV prevention and HIV care for transgender women. .

PI_NAMEs: BAGUSO, GLENDA  (contact)

PROJECT_TERMS: Address;Adoption;Affect;AIDS prevention;Anxiety;Area;assault;Black race;brief intervention;care systems;career;Caring;Clinic;Clinical Trials;community clinic;Community Health Systems;Consolidated Framework for Implementation Research;cost;Data;Department chair;design;Epidemic;Event;evidence base;experience;Face;Funding;Goals;hate crimes;health inequalities;Health Personnel;health service use;HIV;HIV risk;Human immunodeficiency virus test;implementation evaluation;implementation facilitators;implementation outcomes;implementation science;improved;Individual;Interpersonal Violence;intersectionality;Intervention;Interview;Knowledge;Latina;Leadership;Link;marginalized community;Mental Depression;Mental Health;Mental Health Services;Mentors;Methodology;morphogens;Penetration;Persons;Pilot Projects;pilot test;Population;Post-Traumatic Stress Disorders;pre-exposure prophylaxis;preference;Prevention;prevention service;Proctor framework;protective factors;Protocols documentation;Psychosocial Factor;Qualifying;racism;recruit;reduce symptoms;Reporting;Research;Research Personnel;Risk;Risk Factors;San Francisco;School Nursing;screening, brief intervention, referral, and treatment;skills;stem;stressor;structural determinants;Structure;Surveys;Symptoms;therapy development;Training;transgender;transgender women;transphobia;Trauma;trauma exposure;trauma symptom;traumatic event;Treatment outcome;Treatment Protocols;United States National Institutes of Health;uptake;Violence;Viral;Woman;women of color

PROJECT_TITLE: A trauma-informed approach to improve engagement in HIV prevention and HIV care among transgender women


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

PHR: PROJECT NARRATIVE The goals of our postdoctoral training program (Traineeships in AIDS Prevention Studies, or TAPS) are to train the next generation of HIV prevention scientists who will be skilled in diverse research methods, and to increase the number of ethnic/racial minority researchers; and thus we seek to build the skills of postdoctoral fellows to engage in research that combines biomedical, behavioral, social and structural interventions to have the biggest impact on the HIV epidemic and to train more ethnic/racial minority scientists. TAPS balances social/behavioral and biomedical/clinical sides of prevention and is housed in UCSF’s Center for AIDS Prevention Studies (CAPS) within the Division of Prevention Science, with close relationships to other institutions working in HIV prevention. Since the start of TAPS, we have trained 132 fellows who have become leaders in the field and this five-year renewal will permit training of 2-3 new fellows per year, for a total of 6 in the program.

PI_NAMEs: CHARLEBOIS, EDWIN DUNCAN (contact);SANTOS, GLENN-MILO

PROJECT_TITLE: Traineeships in AIDS Prevention Studies

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-N (03)]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Aging;Cancer

ORG_CITY: DUARTE

ORG_NAME: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE

PHR: PROJECT NARRATIVE Almost all human cancers have alterations in metabolic pathways associated with aging and cancer signaling, but undergraduates rarely receive cross-training in cancer, aging, and metabolism research. The proposed Cancer Aging and Metabolism research experience Program (CAMP) will address the need for a well-trained workforce by providing a unique 10-week hands-on learning experience for 20 undergraduates each summer. This first iteration of CAMP will also pilot the integration of school-year academic and research activities with California State University, Dominguez Hills in an effort to bolster the pipeline for undergraduates to thrive as future cancer researchers.

PI_NAMEs: ANN, DAVID K. (contact);LABARGE, MARK A

PROGRAM_OFFICER_NAME: ELJANNE, MARIAM

PROJECT_TERMS: Address;Admission activity;Advanced Malignant Neoplasm;Advisory Committees;Aging;anti-cancer research;Area;Basic Science;Behavioral Research;Big Data;Biomedical Research;California;cancer health disparity;Cancer Hospital;career;Career Choice;career development;Caring;Cell Nucleus;Cities;Clinic;Clinical;Clinical Research;cohort;Collaborations;Communication;Communities;Complement;Creativeness;Critical Thinking;cultural competence;curriculum development;Data Analyses;design;Diabetes Mellitus;disadvantaged student;Disparity population;Doctor of Philosophy;Education;Education Projects;Educational Activities;Educational Curriculum;Educational process of instructing;Educational workshop;Elderly;elementary school;equity, diversity, and inclusion;Evaluation;experience;Exposure to;Faculty;faculty mentor;Feedback;fighting;Financial Support;Flow Cytometry;Funding;Future;General Practitioners;Goals;graduate student;Growth;hands on research;hands-on learning;Home;Human;Image;improved;Incidence;Individual;Infrastructure;innovation;Institution;interest;Journals;Knowledge;Laboratory Research;Learning;Link;Literature;Malignant Neoplasms;Mass Spectrum Analysis;Mentors;Mentorship;Metabolic;Metabolic Pathway;Metabolism;Minority-Serving Institution;Mission;Modernization;Molecular;new technology;next generation;next generation sequencing;Outcome;Pathway interactions;Postdoctoral Fellow;posters;postgraduate education;Process;Productivity;Program Development;Program Evaluation;programs;Pythons;Qualifying;Readiness;recruit;Reproducibility;Research;Research Activity;research and development;Research Institute;Research Personnel;Research Project Grants;Research Training;response;responsible research conduct;Schools;Science;Science, Technology, Engineering and Mathematics;Signal Transduction;skills;Specialist;Spottings;STEM student;Structure;student mentoring;Students;summer internship;summer program;summer research;symposium;synergism;System;Techniques;Time;tool;Training;Translating;Translational Research;Treatment Cost;tumor metabolism;undergraduate research experience;undergraduate student;Underrepresented Populations;Universities;verbal;Writing

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;HIV/AIDS;Immunization;Infectious Diseases;Machine Learning and Artificial Intelligence;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: HONOLULU

ORG_NAME: UNIVERSITY OF HAWAII AT MANOA

ORG_STATE: HI

PHR: Project Narrative An effective HIV vaccine will be useful for stemming the spread of HIV worldwide and domestically. We aim to engineer an immunogen better capable of guiding the development of neutralizing antibodies against diverse HIV strains and to test the design in an established mouse model.

PI_NAMEs: MACPHERSON, IAIN SEIDO (contact)

PROGRAM_OFFICER_NAME: CHAKRABARTI, BIMAL KUMAR

PROJECT_TERMS: Affinity;Amino Acids;Animal Model;Antibodies;Antigen-Antibody Complex;Antigens;Artificial Intelligence;Avidity;B-Cell Activation;B-Cell Antigen Receptor;B-Lymphocytes;Binding;Biochemical;Biological Assay;Cell Lineage;Cells;crosslink;design;design and construction;Development;dimer;Dissociation;Effectiveness;Electrophoretic Mobility Shift Assay;Engineering;Epitopes;Evolution;Exhibits;fitness;Flow Cytometry;Frequencies;Geometry;Germ Lines;Goals;HIV;HIV Envelope Protein gp120;HIV vaccine;Human;Immune Sera;Immunization;Immunize;Immunoglobulin G;Immunologic Monitoring;In Vitro;in vitro testing;insight;Knock-in Mouse;Knock-out;Link;Measurable;Measures;meter;Methods;Modeling;Monitor;mouse model;Mus;mutant;Mutate;Mutation;neutralizing antibody;novel;pathogen;Persons;Phenotype;Polysaccharides;Population;Positioning Attribute;Process;Production;Protein Engineering;Proteins;prototype;Regimen;release of sequestered calcium ion into cytoplasm;Research;scaffold;Scaffolding Protein;Sorting;Splenocyte;stem;success;Surface Plasmon Resonance;Testing;tool;Travel;Vaccine Design;vaccine strategy;Vaccines;Variant

PROJECT_TITLE: HIV Vaccine Design Incorporating Selective Avidity


ORG_CITY: PALO ALTO

ORG_NAME: VETERANS ADMIN PALO ALTO HEALTH CARE SYS

PHR: Veterans are disproportionately susceptible to age-related skeletal muscle wasting known as sarcopenia. Identifying cost-effective interventions to treat sarcopenia is a major public health challenge for Veterans. We propose to develop and test a biomaterials-based sustained delivery of a small molecule drug, in conjunction with rehabilitative exercise, for treating sarcopenia in an aged mouse model. The critical preliminary data generated from this study will establish the feasibility of this approach, ultimately paving the way for further drug development and therapeutic testing towards clinical translation.

PI_NAMEs: HUANG, NGAN F. (contact)

PROJECT_TERMS: age related;aged;Aging;aging population;American;Animal Model;Animals;Arachidonic Acids;Area;Biocompatible Materials;Biological Assay;biomaterial compatibility;Cell-Mediated Cytolysis;Cells;Censuses;clinical translation;combat;Community Surveys;cost effective intervention;cytotoxicity;Data;Dinoprostone;dosage;Drug Delivery Systems;drug development;Drug Exposure;Drug Implants;Drug Screening;efficacy study;efficacy testing;efficacy validation;Electric Stimulation;Enzyme-Linked Immunosorbent Assay;Enzymes;ethylene glycol;Euthanasia;Exercise;exercise rehabilitation;Exposure to;Fatty Acids;FDA approved;Fiber;Functional disorder;gait examination;Generations;Glycolates;Histologic;Human;human old age (65+);Immunofluorescence Immunologic;Impairment;implantation;improved;In Vitro;in vivo;indexing;Individual;Injections;International;Intramuscular Injections;Knowledge;Laminin;Length;Measures;microsphere delivery;Microspheres;military veteran;Modeling;mouse model;Mus;Muscle;muscle engineering;Muscle Fibers;muscle form;Muscle function;muscle physiology;muscle progenitor cell;Muscle satellite cell;muscle strength;Muscular Atrophy;muscular structure;myogenesis;Myosin Heavy Chains;old mice;Pharmaceutical Preparations;Pharmacotherapy;Physiological;Population;Predisposition;Public Health;Randomized;Recommendation;reduced muscle mass;Rehabilitation therapy;response;sarcopenia;Site;Skeletal Muscle;Skeletal Muscle Myosins;skeletal muscle wasting;small molecule;small molecule inhibitor;space station;Stains;System;Testing;therapeutic evaluation;tibialis anterior muscle;transcriptome sequencing;treadmill;Treatment Efficacy;Veterans;Visualization;volumetric muscle loss;Width

PROJECT_TITLE: Combining Prostaglandin E2 Modulation and Rehabilitation for Treatment of Volumetric Muscle Loss

STUDY_SECTION: RRDS

STUDY_SECTION_NAME: Rehabilitation Research and Development SPiRE Program[RRDS]


ADMINISTERING_IC: OH

IC_NAME: NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE  Although air-purifying respirators protect against occupational exposure to harmful particulate matter, in- cluding wildfire smoke or COVID-19, industry-standard filtering facepiece air-purifying respirators can cause con- tact dermatitis, discomfort, and bruising after prolonged wear, obstruction of visual communication, significant environmental waste, and insufficient or unknown filtration capabilities. The proposed design uses electrostatic filtration to overcome many of the barriers of traditional respirators while providing a high degree of protection. The perimetral gap filter removes particles even though the mask does not come in contact with the skin of the wearer’s face.

PI_NAMEs: MAMISHEV, ALEXANDER V;SIMPSON, CHRISTOPHER D (contact)

PROGRAM_OFFICER_NAME: GARRETT, BRIDGETTE E

PROJECT_TITLE: Comfortable Face Mask for Long-Term Wear

STUDY_SECTION: SOH

STUDY_SECTION_NAME: Safety and Occupational Health Study Section[SOH]


ORG_CITY: TUCSON

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: The more than one million firefighters in the United States provide critical emergency medical services in communities they serve and are on the front lines of healthcare delivery, including in the post-pandemic world. As a result of exposure to occupational stressors, a high proportion of firefighters experience considerable stress-related burden including psychological distress (i.e., anxiety and depression). To address this need, this project will test the efficacy of an app-based meditation intervention to improve well-being among career firefighters.

PI_NAMEs: PACE, THADDEUS  (contact)

PROGRAM_OFFICER_NAME: LIOCE, MARIA

PROJECT_TITLE: Reducing Psychological Distress in Fire Fighters with an Asynchronous App-based Meditation Intervention


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Cystic Fibrosis;Emerging Infectious Diseases;Genetics;Infectious Diseases;Lung;Orphan Drug;Pneumonia;Pneumonia and Influenza;Rare Diseases

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: Project Narrative Antibiotic resistance among gram-negative bacterial pathogens is becoming increasingly frequent. This is particularly true in patients who suffer from chronic infections or are immunocompromised, such as in those with cystic fibrosis. One pathogen that causes significant morbidity and mortality is Pseudomonas aeruginosa. We have developed antisense molecules that effectively kill this pathogen, including in drug-resistant isolates. We will further characterize our lead antisense molecules and nominate an ultimate lead for IND submission.

PI_NAMEs: GREENBERG, DAVID ELIHU (contact)

PROGRAM_OFFICER_NAME: XU, ZUOYU

PROJECT_TERMS: analytical method;Anti-Bacterial Agents;anti-microbial drug;Antibiotic Resistance;Antibiotics;antimicrobial;Antisense Oligonucleotides;Automobile Driving;Bacteremia;Bacterial Infections;Biological;Cells;Centers for Disease Control and Prevention (U.S.);chronic infection;Clinical;Clinical Trials;Collaborations;Collection;combat;comparison control;Cystic Fibrosis;cystic fibrosis patients;Development;Dose;drug discovery;Drug Kinetics;Drug resistance;Duchenne muscular dystrophy;Effectiveness;efficacy evaluation;efficacy study;Enzyme-Linked Immunosorbent Assay;Enzymes;Essential Genes;fatty acid biosynthesis;FDA approved;Formulation;Frequencies;Gene Silencing;Gene Targeting;Genes;Goals;healthcare-associated infections;Immunocompromised Host;improved;In Vitro;in vivo;indexing;Infection;innovation;interest;Investigation;Lead;Libraries;Life;Lipid A;loss of function;Lung;Lung infections;Marketing;Messenger RNA;Methods;Minimum Inhibitory Concentration measurement;Modeling;Morbidity - disease rate;mortality;Multi-Drug Resistance;multidrug-resistant Pseudomonas aeruginosa;Mus;Mutation;Nosocomial Infections;novel;novel therapeutics;Organism;pathogen;pathogenic bacteria;Pathogenicity;Patients;Penetration;Peptides;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;Pharmacologic Substance;Phase;Phase I Clinical Trials;phosphorodiamidate morpholino oligomer;Pneumonia;pneumonia model;Positioning Attribute;pre-clinical;preclinical development;Preclinical Testing;prevent;Process;Production;Protein Subunits;Proteins;Pseudomonas;Pseudomonas aeruginosa;Pseudomonas aeruginosa infection;Regimen;Research;Resistance;Resistance development;resistance frequency;resistant strain;Ribosomes;Risk;Rodent;Safety;safety study;screening;Sepsis;Site;small molecule;Specificity;success;technology platform;Therapeutic;Therapeutic Agents;Tissues;Toxic effect;Toxicology;Transcript;Translational Repression;Translations

PROJECT_TITLE: Development of Gene-Silencing Therapeutics for Pseudomonas aeruginosa


ORG_CITY: LOUISVILLE

ORG_NAME: LOUISVILLE VA MEDICAL MEDICAL CENTER

ORG_STATE: KY

PHR: The project aims to validate new genetic models for studying the mechanisms underlying painful neuroma which occurs after nerve injury and seriously impacts Veterans’ quality of life, engagement with rehabilitation, and use of prosthetics. The causes of painful neuroma are not known, which hinder development of treatments and preventions. The proposed work will take a basic science approach to enable new types of experiments to answer some of the fundamental questions which will directly influence the design of translational strategies.

PI_NAMEs: PETRUSKA, JEFFREY C (contact)

PROJECT_TERMS: activating transcription factor 3;Address;Afferent Neurons;Amputation;Amputees;Animal Model;Animals;Automobile Driving;Axon;axon injury;axon regeneration;Basic Science;Biological;Biological Factors;Biological Models;Breeding;Cell Proliferation;cell type;Cells;Chronic;Clinical;Communities;comorbidity;Country;Coupling;Data;Dependence;design;Development;Devices;Diabetes Mellitus;Disease;Etiology;Excision;Experimental Designs;experimental study;Future;Genes;Genetic Models;Goals;Growth;Health;Image;Immune;improved;improved outcome;Injury;innovation;Investigation;Knock-out;knockout gene;Knockout Mice;Local Anesthetics;loss of function;Methods;model design;Modeling;Motor;motor axon regeneration;Mus;Natural regeneration;Nerve;nerve injury;Nerve Pain;Nerve Tissue;Neuroma;Neurons;Normal tissue morphology;novel;Operative Surgical Procedures;optogenetics;Pain;Patients;Peripheral;Peripheral nerve injury;Pharmacogenetics;Physical Rehabilitation;Physical therapy;Population;prevent;Prevention;Preventive therapy;Property;Prosthesis;Proteins;Quality of life;recruit;Recurrence;regenerative;Rehabilitation therapy;Reporter;Research;Resources;response;Schwann Cells;Self-Help Devices;Sensory;Signal Transduction;standard of care;Structure;Study models;Testing;Therapeutic;therapy design;therapy development;three dimensional structure;Time;tool;Transgenic Mice;translational approach;Trauma;tumor;Validation;Veterans;Visualization;Work

PROJECT_TITLE: Developing Novel Models for Assessing Fundamental Mechanisms of Neuroma


NIH_SPENDING_CATS: Biotechnology;Cystic Fibrosis;Genetics;Human Genome;Lung;Orphan Drug;Rare Diseases

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE Despite the many exciting advances in gene editing technologies since the advent of CRISPR-Cas9, the field has been hampered by an inability to catalyze programmable and predictable insertion of large DNA payloads without generating double-strand breaks. The recent discovery and development of CRISPR-associated transposons offers an exciting new strategy to insert large genetic cargos (>10kb) with high integration efficiencies and virtually no off-target events. This proposal aims to systematically optimize CRISPR- associated transposons in human cells to achieve therapeutically relevant editing efficiencies, and to apply them for the universal correction of CFTR gene mutations that cause cystic fibrosis.

PI_NAMEs: KING, REBECA TERESA (contact)

PROGRAM_OFFICER_NAME: REYES, MADELYN

PROJECT_TERMS: Affect;Age;Alleles;autosome;Biological Assay;bronchial epithelium;Candidate Disease Gene;Caucasians;Cell Separation;Cells;Cessation of life;Chloride Channels;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Code;Complementary DNA;Complex;CRISPR-associated transposons;CRISPR/Cas technology;Cystic Fibrosis;cystic fibrosis patients;Cystic Fibrosis Transmembrane Conductance Regulator;Development;Disease;DNA;DNA Integration;DNA Transposable Elements;Doctor of Philosophy;Epithelial Cells;Escherichia coli;Event;Exhibits;functional restoration;gene editing technology;Gene Expression Regulation;Gene Mutation;Genes;Genetic;Genetic Diseases;genetic payload;Genome;genome-wide;genomic locus;Guide RNA;Human;Human Genome;improved;Individual;insertion/deletion mutation;Introns;Ion Channel;Length;lipofection;Messenger RNA;Methods;Modification;Molecular Target;Mutation;Nonhomologous DNA End Joining;novel therapeutics;nucleofection;Other Genetics;Pathway interactions;Patients;Persons;Pharmaceutical Preparations;Phenotype;Physiological;Plasmids;Population;Positioning Attribute;Production;Proteins;reconstitution;Regulator Genes;repaired;Respiratory Failure;restoration;Ribonucleoproteins;RNA;RNA Splicing;Safety;Sequence Deletion;Specificity;survival prediction;System;Technology;Therapeutic;tool;Transcript;Transfection;Transposase;United States;virtual;Western Blotting

PROJECT_TITLE: Leveraging CRISPR RNA-guided DNA Transposases for Gene Insertion at the CFTR Locus

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F08-M(20)L]