ORG_CITY: Aurora

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF COLORADO DENVER

PHR: The goal of this project is to engineer tumor-specific T cells to increase their migration into solid tumors and enhance their anti-tumor activity. The findings from this exploratory project have the potential to enable new approaches to improve T cell-based anti-tumor therapies such as chimeric antigen receptor (CAR) T cell and tumor-infiltrating lymphocyte (TIL) therapy for solid tumors.

PI_NAMEs: JACOBELLI, JORDAN  (contact)

PROGRAM_OFFICER_NAME: BOURCIER, KATARZYNA

PROJECT_TERMS: Address;Adoptive Transfer;anti-CTLA4;anti-PD-L1;antigen-specific T cells;Antitumor Response;Biomedical Engineering;cancer therapy;capsule;CAR T cell therapy;cell motility;Cellular immunotherapy;checkpoint therapy;chimeric antigen receptor;chimeric antigen receptor T cells;Collagen;comparison control;Cytoskeleton;Data;engineered T cells;Engineering;Environment;Exclusion;exhaustion;experience;experimental study;Extracellular Matrix;Extravasation;Failure;Flow Cytometry;FMNL1 gene;follow-up;Future;Goals;Histology;Image;Immune checkpoint inhibitor;Immunotherapy;Implant;improved;In Situ;in vivo;in vivo imaging;Infiltration;interstitial;Knowledge;Location;Malignant Neoplasms;Melanoma;Melanoma Tumor;migration;Modeling;Motility;mouse model;Mus;mutant;neoplasm immunotherapy;neoplastic cell;novel strategies;overexpression;Patients;Prognosis;Proteins;recruit;Site;Solid Neoplasm;Specificity;Structure;System;T cell infiltration;T cell regulation;T cell therapy;T-Lymphocyte;Testing;Time;Tissues;trafficking;tumor;Tumor Antigens;tumor microenvironment;Tumor-Associated Vasculature;tumor-immune system interactions;Tumor-Infiltrating Lymphocytes;two photon microscopy;Work

PROJECT_TITLE: Engineered T cells for improved migration into solid tumor sites

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-K (J2)]


ADMINISTERING_IC: AI

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: Chicago

ORG_COUNTRY: UNITED STATES

ORG_DEPT: CHEMISTRY

ORG_FIPS: US

ORG_NAME: NORTHWESTERN UNIVERSITY

ORG_STATE: IL

PHR: Project Narrative: Proteoforms play key roles in human health and disease and are effective markers for differentiating cell types and heterogeneous cell populations. The proposed research develops a suite of high-throughput technologies for enhanced proteoform profiling of tissue-contained single cells particularly rare cells. This proposal will uncover novel molecular signatures for tissue-resident innate immune cells and expand our knowledge on their roles to furnish novel therapeutic strategies in relevant diseases.

PI_NAMEs: SU, PEI  (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Address;Algorithms;animal tissue;Anti-Inflammatory Agents;Bioinformatics;Biological;Biological Models;biological systems;biomedical scientist;Biomedical Technology;Biopsy;blind;career;Cell Differentiation process;cell preparation;cell type;Cells;Collaborations;combinatorial;Communities;Complex;Coupled;Data;data acquisition;Dendritic Cells;Detection;Development;Diagnosis;diagnostic tool;Differentiation Antigens;Digestion;Disease;disease diagnostic;Dissociation;drug development;Electrons;Enhancement Technology;Foundations;Goals;Health;Heterogeneity;high throughput technology;Hippocampus;Human;human tissue;Image;Immune;Immunobiology;Immunohistochemistry;Immunophenotyping;Inflammatory;Innate Immune System;innovation;instrumentation;interest;Kidney;kidney allograft;kidney biopsy;kidney cell;Knowledge;knowledgebase;Libraries;Macrophage;mass spectrometric imaging;Mass Spectrum Analysis;Medical;Mentors;Modification;Molecular;Molecular Profiling;Molecular Weight;nanolitre scale;new technology;novel;novel therapeutic intervention;Nucleic Acids;Pathology;Pattern;personalized approach;Phenotype;Play;Population;Post-Translational Protein Processing;Preparation;Proteins;Proteome;Proteomics;Protocols documentation;Publishing;Rattus;Research;Role;Sampling;Science;Series;single molecule;Site;Solid;Speed;Surface;Techniques;Technology;technology development;Testing;therapeutic target;Tissue Sample;Tissues;tool;tool development;Training;Validation;Variant;Work

PROJECT_TITLE: Single Cell Proteoform Profiling using Top-Down Mass Spectrometry

STUDY_SECTION: AITC

STUDY_SECTION_NAME: Allergy, Immunology, and Transplantation Research Committee[AITC]


ADMINISTERING_IC: VA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: Veterans Affairs

ORG_NAME: VA EASTERN COLORADO HEALTH CARE SYSTEM

ORG_STATE: CO

PHR: This project is relevant to all aspects of VA healthcare for it will test the feasibility and acceptability of a novel Relational Playbook combined with a leadership coaching implementation strategy for frontline managers to cultivate supportive learning environments. This work will inform national efforts to enhance employee well- being due to crisis levels of employee burnout and turnover. The Playbook consists of research-based re- sources and 50 evidence-based practices for teams, including how to assess team well-being, address difficult relationships, and implement hiring best practices. We will pilot the Playbook with 1:1 virtual leadership coach- ing to inspire nurse managers to improve their team culture. We will conduct a mixed methods process evalua- tion to inform a pragmatic adaptive effectiveness trial. We expect this study to demonstrate the Playbook com- bined with coaching is a feasible and acceptable approach to create supportive learning environments that im- prove employee well-being and address factors contributing to employee burnout and turnover.

PI_NAMEs: GILMARTIN, HEATHER M. (contact)

PROJECT_TERMS: Academy;acceptability and feasibility;Address;Adopted;Area;Behavior;burnout;Cardiac Catheterization Procedures;Cardiology;Caring;Clinical;Communication;Complex;cost;Data;design;educational atmosphere;Educational Curriculum;effectiveness testing;effectiveness trial;Employee;empowerment;Enrollment;Ensure;Environment;Equity;Evaluation;Evidence based intervention;Evidence based practice;feasibility testing;frontier;Goals;Habits;Health system;Healthcare;Hip region structure;implementation barriers;implementation facilitators;implementation intervention;implementation strategy;improved;innovation;Intervention;Interview;Investments;Job Satisfaction;Laboratories;Leadership;leadership development;Learning;Literature;Measures;Medicine;Methodology;Methods;Modeling;novel;Nurses;nursing intervention;Nursing Services;Office Nursing;Personal Satisfaction;Procedures;process evaluation;Randomized;randomized trial;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Research;Research Priority;Resources;Science;Site;Speed;Surveys;System;Testing;tool;Training;trial design;Veterans;Veterans Health Administration;virtual;Work

PROJECT_TITLE: A Pilot Feasibility and Acceptability Study of a Relational Playbook and Coaching Intervention for Cardiology Teams to Enhance Employee Well-being and Veteran Care

STUDY_SECTION_NAME: HSR-1 Health Care and Clinical Management[HSR1]


ADMINISTERING_IC: AR

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Genetics

ORG_CITY: STANFORD

ORG_DEPT: DERMATOLOGY

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: GLUCOSE BINDS RBPs TO REGULATE EPIDERMAL HOMEOSTASIS  Project Narrative The maintenance of epithelial tissue is orchestrated by an interplay of regulatory factors that control transcription, RNA processing, translation and protein modification that together balance the decisions to divide, differentiate or enter senescence. Breakdowns in this regulatory system lead to skin diseases, such as psoriasis or cancer. In this proposal, we aim to elucidate the molecular mechanisms by which glucose regulates the activity of RNA- binding proteins and their interacting targets in the context of epidermal differentiation, with the ultimate goal of developing new therapeutic strategies for the treatment of skin diseases.

PI_NAMEs: MIAO, WEILI  (contact)

PROGRAM_OFFICER_NAME: KOCH, PETER

PROJECT_TERMS: Affect;Affinity;Affinity Chromatography;American;Area;Binding;Bioinformatics;Biology;blood glucose regulation;career;Categories;Cell Nucleolus;Cells;Chemistry;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;Coupled;Cytosine;Data;Dermatology;Differentiated Gene;dimer;Dimerization;Dissociation;DNA Binding;Environment;Epidermis;Epithelium;Equilibrium;Event;Flow Cytometry;Fluorescent in Situ Hybridization;gene induction;Gene Proteins;Genes;Genomics;Glucose;Glucose Transporter;Goals;helicase;Homeostasis;Human;insight;interest;Investigation;keratinocyte;Knock-out;Laboratories;Lead;Maintenance;Malignant Neoplasms;Mass Spectrum Analysis;Mediating;Messenger RNA;Metabolic;Metabolism;Modeling;Molecular;Molecular Biology;monomer;novel;novel therapeutic intervention;Nucleoplasm;Ontology;Physiological;Play;Population;Post-Translational Protein Processing;Proliferating;protein function;Proteins;Proteomics;Psoriasis;Regulation;Research;RNA;RNA Binding;RNA Helicase;RNA Processing;RNA Splicing;RNA-Binding Proteins;RNA-Protein Interaction;Role;S-Adenosylhomocysteine;S-Adenosylmethionine;Scientist;screening;senescence;Set protein;Skin;skin disorder;Specificity;statistics;System;Techniques;Testing;Tissues;Training;transcription factor;Transcriptional Regulation;Translations;treatment strategy;whole genome

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

ORG_CITY: BALTIMORE

ORG_DEPT: PSYCHIATRY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Schizophrenia (SZ) is a chronic mental disease in which specific clinical domains [e.g., negative symptoms (the lack of motivation and inability to feel pleasure) and social cognitive deficits] are particularly least responsive to treatment, making patients’ prognosis and functionality even more devastating. Based on promising pilot studies in our group, we hypothesize a significant contribution of the olfactory system in these clinical domains. We will elucidate the mechanism of how the pathology of the olfactory epithelium alters the olfactory system and, in turn, higher brain function in animal models, and then we will validate the notion in patients with early-stage SZ.

PI_NAMEs: SAWA, AKIRA  (contact)

PROGRAM_OFFICER_NAME: ZALCMAN, STEVEN J

PROJECT_TERMS: Address;Adolescence;Animal Model;associated symptom;Basic Science;Behavior;Behavioral;Biopsy;Brain;Brain imaging;Cells;Chronic;Clinical;Cognitive deficits;cranium;critical developmental period;Data;Disease;Education;Functional disorder;hippocampal pyramidal neuron;Human;imaging study;Immune;Inflammation;Inflammatory;insight;interest;Intervention;Knowledge;Leadership;Link;Molecular;Motivation;mouse model;Mus;neural;Neurons;Nose;Olfactory Epithelium;Olfactory Pathways;outreach;Oxidation-Reduction;Pathologic;Pathology;patient prognosis;patient stratification;Patients;Pharmaceutical Preparations;Pilot Projects;pleasure;Positive Valence;pre-clinical;Prefrontal Cortex;Psyche structure;recruit;Refractory;Reporting;Reproducibility;research study;Schizophrenia;secondary outcome;Signal Transduction;Smell Perception;social;Social Processes;Symptoms;System;Tissues;translational potential;young adult

PROJECT_TITLE: Impact of the olfactory system on higher brain function and schizophrenia

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-E (01)]


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Mental Health;Mental Illness;Neurosciences;Schizophrenia;Serious Mental Illness

PROJECT_TERMS: Administrator;Animal Behavior;Animals;Attention;Awareness;Behavior assessment;Brain;Brain Diseases;Charge;Clinical assessments;Collaborations;Communication;Confusion;Country;data management;data resource;Data Set;data sharing;Databases;Decision Making;Development Plans;Education;Education and Outreach;Educational workshop;equity, diversity, and inclusion;Family;Family member;Future;General Population;Goals;Grant;Group Meetings;Human;human subject;improved;Individual;innovation;Institution;Internet;Lead;Leadership;Link;Maintenance;Medical;meetings;member;Mind;multidisciplinary;Mus;Olfactory Epithelium;Olfactory Pathways;open data;operation;Pathology;Patients;peer;Pennsylvania;Periodicals;Physicians;Play;programs;Protocols documentation;public education;Recording of previous events;recruit;Research;Research Design;Research Personnel;Schizophrenia;Science;scientific organization;Series;Services;Site;Societies;Standardization;Students;Subgroup;symposium;Translations;Universities;Update;Validation;web page

PROJECT_TITLE: Core A


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Mental Illness;Neurosciences;Schizophrenia;Serious Mental Illness

PI_NAMEs: LANE, ANDREW P (contact)

PROJECT_TERMS: Address;Adolescence;Adult;Affect;Anterior;Basal Cell;Behavior;Behavioral;behavioral outcome;behavioral phenotyping;Brain;Brain region;Cell Cycle;cell type;Cells;Cerebral cortex;Chronic;clinical phenotype;Clinical Research;Cognitive deficits;cognitive process;Collaborations;critical period;Data;experimental study;genetic manipulation;Human;Immune;Immunohistochemistry;Impairment;in vivo;Inflammation;Inflammatory;insight;inward rectifier potassium channel;Medial;Modeling;Molecular;molecular pathology;Motivation;mouse model;Mus;neural;neurobehavioral;Neuronal Dysfunction;Neurons;neurotransmission;olfactory bulb;Olfactory Cortex;Olfactory dysfunction;Olfactory Epithelium;olfactory nuclei;Olfactory Pathways;olfactory sensory neurons;Outcome;overexpression;Oxidation-Reduction;Pathologic;Pathology;Pathway interactions;Patients;Phenotype;piriform cortex;Positive Valence;Prefrontal Cortex;Psychopathology;Reporting;Reproducibility;response;Schizophrenia;Sensory;single-cell RNA sequencing;Smell Perception;social;social cognition;Social Processes;stem cells;Structure;Symptoms;Synapses;System;young adult

PROJECT_TITLE: Project 1


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Neurosciences;Pediatric;Schizophrenia;Serious Mental Illness

PI_NAMEs: MA, MINGHONG  (contact)

PROJECT_TERMS: Adolescence;Adult;Affect;Anhedonia;Anterior;awake;Axon;Behavior;Behavior assessment;Behavioral;Brain;Chronic;Clinical;Cognition;Cognitive deficits;Collaborations;Complement;Consultations;critical period;Data;Delusions;Disease;Electrophysiology (science);Event;Fiber;Functional disorder;Functional Magnetic Resonance Imaging;Genetic;Genus Tenia;Hallucinations;hippocampal pyramidal neuron;Human;human study;Immune;Impairment;in vivo;Incidence;Inflammation;Inflammatory;insight;Knowledge;Link;Medial;Molecular;Motivation;mouse model;Mus;neural;neural circuit;Neurobiology;Neurons;novel;olfactory bulb;Olfactory Cortex;Olfactory Epithelium;olfactory nuclei;Olfactory Pathways;olfactory sensory neurons;Oxidation-Reduction;patch clamp;Pathologic;Pathology;Patients;Photometry;piriform cortex;Positive Valence;Prefrontal Cortex;Process;Property;Refractory;Reinforcement Schedule;Reporting;Reproducibility;Rest;Role;Schizophrenia;Smell Perception;social;social cognition;social deficits;Social Interaction;Social Processes;Symptoms;Synapses;System;Testing;Time;transmission process;young adult

PROJECT_TITLE: Project 2


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Neurosciences;Schizophrenia;Serious Mental Illness

PROJECT_TERMS: Address;Adult;Affect;Air Pollution;Anatomy;Anhedonia;Animal Model;Attention;Back;Basal Cell;Behavioral;Biopsy;Brain;cell type;Cells;Characteristics;Chronic;Clinical;Clinical Data;Cognitive deficits;cranium;Data;Delusions;Disease;environmental stressor;First Degree Relative;Functional disorder;Genes;Hallucinations;hippocampal pyramidal neuron;Human;human data;Immune;Immunohistochemistry;Individual;Inflammation;Inflammatory;interest;Knowledge;Longitudinal cohort;Maintenance;Measures;Mediating;Mediation;Molecular;molecular pathology;mouse model;multimodal data;Mus;Neurobehavioral Manifestations;neuron regeneration;Neurons;olfactory bulb;Olfactory Epithelium;Olfactory Pathways;olfactory sensory neurons;Oxidation-Reduction;Pathologic;Pathology;Pathway interactions;patient stratification;Patients;Peripheral;Pharmaceutical Preparations;Positive Valence;Prefrontal Cortex;Protocols documentation;Psychophysics;Publishing;Reporting;Reproducibility;Research;Role;Schizophrenia;secondary outcome;single-cell RNA sequencing;Smell Perception;social;Specificity;stem cells;Study models;Symptoms;System;Tissues;transcriptome sequencing;Translating;transmission process;Virus Diseases

PROJECT_TITLE: Project 3


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biodefense and Related Countermeasures;Biomedical Imaging;Brain Disorders;Clinical Research;Coronaviruses;Emerging Infectious Diseases;Infectious Diseases;Mental Health;Mental Illness;Neurosciences;Psychosis;Schizophrenia;Serious Mental Illness

PI_NAMEs: MILLER, MICHAEL I (contact)

PROJECT_TERMS: Address;Anhedonia;Animal Model;Anterior;Applications Grants;Appointment;area striata;Attention;Behavioral;behavioral health;Biopsy;Blood specimen;Brain;Brain imaging;Brain Mapping;Cells;cingulate cortex;Clinic;Clinical;Clinical assessments;clinical imaging;Clinical Research;Cognitive deficits;cohort;Collaborations;Collection;COVID-19;COVID-19 diagnosis;COVID-19 impact;COVID-19 vaccination;Data;data acquisition;Data Analyses;data analysis pipeline;data management;data modeling;Delusions;Disease;Enrollment;Exclusion;Exclusion Criteria;experience;Faculty;first episode psychosis;Foundations;Functional disorder;Functional Magnetic Resonance Imaging;Generations;Goals;Hallucinations;Health;Hospitals;Human;human data;Image;imaging facilities;imaging science;imaging study;inclusion criteria;Infrastructure;innovation;interest;Lead;Long COVID;Magnetic Resonance Imaging;Maryland;Medial;Mediating;member;Molecular;Monitor;multimodal data;Mus;National Institute of Mental Health;Neurobiology;Neurons;Nose;olfactory bulb;Olfactory Epithelium;Olfactory Pathways;Outcome;Participant;Patient Recruitments;Patients;Pharmaceutical Preparations;Physicians;Positive Valence;Prefrontal Cortex;Process;Productivity;Psychiatric Diagnosis;Psychiatrist;Psychiatry;Psychoses;recruit;Reproducibility;Research;Research Design;Research Domain Criteria;Research Personnel;Rest;Schizophrenia;secondary outcome;Services;Sinus;Smell Perception;social;Social Processes;Statistical Data Interpretation;structural imaging;Symptoms;System;Time;Training;Translational Research;Universities

PROJECT_TITLE: Core B


NIH_SPENDING_CATS: Brain Disorders;Data Science;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Neurosciences;Schizophrenia

PI_NAMEs: YOUNES, ELIE LAURENT (contact)

PROJECT_TERMS: Address;Affect;Anatomy;Attention;Behavior;Biological;Biological Markers;Brain;Brain imaging;Cells;Clinical;comparison group;Computational Biology;Data;Data Analyses;Data Science;Disease;Electrophysiology (science);Ensure;Graph;Guidelines;Heterogeneity;Human;human data;Immune;Immunohistochemistry;Inflammatory;innovation;Instruction;invention;Longitudinal Studies;Malignant Neoplasms;Mediating;Mediation;Medical Research;Mental disorders;Methods;Minority;Molecular;multimodal data;Mus;neuroimaging;Neurons;novel;Olfactory Epithelium;Olfactory Pathways;Oxidation-Reduction;Pathologic;Pathology;patient stratification;Patients;Population;power analysis;predict clinical outcome;Protocols documentation;Psychiatry;random forest;Reproducibility;Research;Role;Sample Size;Sampling;Schizophrenia;single-cell RNA sequencing;Solid;Standardization;Statistical Data Interpretation;Techniques;Testing;transcriptome sequencing;Visit

PROJECT_TITLE: Core C


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Infectious Diseases;Prevention;Social Determinants of Health

ORG_CITY: SEATTLE

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE Multiplex molecular panels have facilitated the diagnosis of patients presenting with acute diarrhea and enabled the rapid detection of diarrheagenic E. coli which were previously overlooked by conventional clinical laboratory methods. Enteropathogenic (EPEC) and enteroaggregative (EAEC) E. coli are now among the most common pathogens detected by these panels. Yet, although both are established as causes of diarrhea in infants living in developing countries, little is known about their clinical relevance in adult patients living in high-income countries. The proposed research will examine the clinical features, epidemiology, and antimicrobial resistance of EPEC/EAEC infections in U.S. adults to better understand their importance and to inform strategies for their prevention and management.

PI_NAMEs: TANSARLI, GIANNOULA  (contact)

PROGRAM_OFFICER_NAME: BAQAR, SHAHIDA

PROJECT_TERMS: Acute Diarrhea;Adult;Anti-microbial susceptibility;Antimicrobial Resistance;Area;Bacterial Infections;Bioinformatics;Calendar;career development;Characteristics;Child;Chronic diarrhea;Clinical;clinical epidemiology;clinically relevant;clinically significant;Communicable Diseases;Country;Developing Countries;Development Plans;Diagnosis;Diarrhea;Diarrheagenic E. coli;Disease Resistance;Electronic Health Record;enteroaggregative Escherichia coli;enteropathogenic Escherichia coli;Epidemiology;epidemiology study;European;Exhibits;experience;FDA approved;Feces;Gastroenteritis;gastrointestinal;gastrointestinal symptom;General Population;genome sequencing;Genomics;Goals;HIV Seropositivity;Homelessness;Income;Infant;Infection;Infectious Disease Epidemiology;insight;Institution;International;Laboratories;low and middle-income countries;men who have sex with men;Mentors;Methods;Molecular;Molecular Epidemiology;Morbidity - disease rate;mortality;Multicenter Studies;Natural History;next generation sequencing;novel;Organism;Outcome;pathogen;Pathogen detection;Patients;Pattern;Persons;Phenotype;Population;Populations at Risk;Prevalence;Prevalence Study;Prevention;Productivity;prospective;Prospective Studies;rapid detection;repository;Research;Research Personnel;Residual state;Retrospective cohort study;Retrospective Studies;Risk Factors;Sampling;Sanitation;Scientist;Shigella;Statistical Data Interpretation;stool sample;Technology;Testing;Time;Training;Training Activity;transmission process;Travel;Universities;Urban Hospitals;Virulence Factors;Washington;whole genome

PROJECT_TITLE: The molecular epidemiology of enteropathogenic (EPEC) and enteroaggregative (EAEC) Escherichia coli among adult patients in Seattle

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases B Research Study Section[MID-B]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Mental Health;Pediatric;Pediatric Cancer;Physical Rehabilitation;Prevention;Rare Diseases;Rehabilitation;Social Determinants of Health;Telehealth;Women's Health Research

ORG_CITY: BOSTON

ORG_NAME: DANA-FARBER CANCER INST

ORG_STATE: MA

PHR: Project Narrative Although treatment-related sexual dysfunction is one of the most prevalent and distressing side effects for young adult female cancer survivors, help for sexual dysfunction remains largely unavailable. To address this pressing need, we propose to test SHAREonline, a synchronous online educational intervention delivered by a trained presenter. SHAREonline has the potential to improve sexual function and quality of life for thousands of young adult survivors by delivering sexual health rehabilitation in a format that is brief, efficient and easily accessible.

PI_NAMEs: BOBER, SHARON L. (contact)

PROGRAM_OFFICER_NAME: ETON, DAVID T

PROJECT_TERMS: Address;Adherence;Adult women;advocacy organizations;Age;Anxiety;arm;Arousal;Atrophic;attentional control;Awareness;behavior change;behavior test;Behavioral;behavioral health intervention;biopsychosocial;Body Image;Breast Cancer survivor;Cancer Burden;cancer diagnosis;Cancer Intervention;Cancer Patient;cancer risk;Cancer Survivor;Cancer Survivorship;cancer therapy;Caring;Chronic;Clinical;clinically significant;Collaborations;Competence;Control Groups;cost;Data;Development;Distress;Dropout;E-learning;Education;Educational Intervention;Educational Materials;efficacy trial;Elements;Ensure;Ethnic Origin;Evaluation;evidence base;Female;follow-up;Future;Goals;Health;Home;Hour;Impairment;improved;Individual;Intervention;Malignant Neoplasms;Materials Testing;Mental Depression;mindfulness based cognitive therapy;Modeling;novel;online delivery;online intervention;Ovariectomy;Pain;Participant;Patients;Persons;Phase;pilot trial;post intervention;preference;Preparation;primary outcome;Provider;psychologic;psychological distress;Quality of life;Race;Randomized;Randomized, Controlled Trials;Recovery;Regimen;Rehabilitation therapy;Reporting;Research;response;Risk Reduction;Sampling;satisfaction;secondary outcome;Self Determination;Self Efficacy;self esteem;Self Management;Sex Behavior;Sex Functioning;Sexual Dysfunction;Sexual Health;sexual identity;side effect;skills;sociodemographics;success;Survivors;survivorship;Telephone;Testing;theories;Time;Training;Travel;treatment as usual;Treatment Side Effects;uptake;videoconference;Videoconferencing;Well in self;Woman;Work;young adult;young cancer survivor;young woman

PROJECT_TITLE: Sexual Health and Rehabilitation (SHARE): An Online Educational Intervention for Young Adult Female Cancer Survivors

STUDY_SECTION: BMHO

STUDY_SECTION_NAME: Biobehavioral Medicine and Health Outcomes Study Section[BMHO]


ORG_CITY: HOUSTON

ORG_NAME: MICHAEL E DEBAKEY VA MEDICAL CENTER

ORG_STATE: TX

PHR: Oropharyngeal cancer (OPC) incidence in the Veteran population is increasing at a rate 3 times that of the general US population and survival lags that of the US population by >20% due to a disproportionate burden of aggressive, treatment resistant disease. These factors combine to make rapid development of precision oncology approaches to OPC a categorical imperative for the VHA. In the current proposal we will utilize machine learning approaches to develop the Artificial Intelligence for Risk Stratification of Oropharyngeal Carcinoma (AIROC) algorithm which will predict chemo-radiation response in patients with OPC with a sensitivity and specificity greater than 95% using clinically generated data readily available across the VHA that can be easily deployed across VHA facilities for utilization in clinical practice and planned clinical trials for this deadly disease.

PI_NAMEs: MADABHUSHI, ANANT ;SANDULACHE, VLAD C (contact)

PROJECT_TERMS: active duty;Acute;Aftercare;Algorithms;Anatomy;Artificial Intelligence;Biological Markers;Biopsy;Blinded;Cancer Biology;Cancer Patient;cancer survival;Categories;chemoradiation;chemotherapy;Clinical;Clinical Data;Clinical Management;clinical practice;Clinical Trials;Clinical Trials Cooperative Group;Clinical Trials Network;cohort;Complex;Computer Vision Systems;contrast enhanced computed tomography;Data;data repository;Databases;design;Development;Diagnostic;Disease;Disease Resistance;disorder risk;Epidemic;Event;Eye;Future;Hematoxylin and Eosin Staining Method;high risk;HPV oropharyngeal cancer;Human;Human papilloma virus infection;Human Papilloma Virus Vaccination;Image;imaging study;Incidence;individual patient;Institution;lymph nodes;Machine Learning;machine learning model;malignant oropharynx neoplasm;Measurement;military veteran;Morbidity - disease rate;mortality;multidimensional data;multimodal data;Network Infrastructure;Oncogenic;Oncologist;Outcome;Outcome Measure;Pathologic;Pathology;patient stratification;Patients;Pattern;Population;precision oncology;predicting response;prediction algorithm;Primary Neoplasm;primary outcome;prognostic;Progression-Free Survivals;Prospective cohort;radiation response;Radiation therapy;radiomics;Recurrence;Refractory Disease;Resistance;response;Risk;risk stratification;secondary outcome;Selection for Treatments;Sensitivity and Specificity;service member;Site;Slide;Specificity;Stains;standard of care;Stratification;success;Testing;Therapeutic;tool;translational potential;Treatment Efficacy;treatment optimization;treatment response;tumor;Tumor Volume;user-friendly;Validation;Veterans

PROJECT_TITLE: An imaging AI-driven predictive chemoradiation response tool for Veterans with oropharyngeal cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 SPLP-Y (01)]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: CHICAGO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CHICAGO

PHR: OVERALL COMPONENT – PROJECT NARRATIVE The Rare and Atypical Diabetes Network (RADIANT) enrolls and deeply characterizes individuals with rare and atypical forms of diabetes. Whole-genome sequencing could help identify new genetic variants and metabolomics and transcriptomics analysis novel pathogenic mechanisms and biomarkers for atypical forms of the disease. Its ultimate goal is to enable a more precise, etiologically based clinical classification of diabetes.

PI_NAMEs: PHILIPSON, LOUIS H. (contact);UDLER, MIRIAM SARGON

PROGRAM_OFFICER_NAME: WANG, XUJING

PROJECT_TERMS: Address;Autoantibodies;Biochemical;Biological;Biological Markers;Biological Specimen Banks;candidate identification;Case Study;causal variant;Cell Physiology;Chicago;Classification;Clinical;clinical center;clinical practice;Collection;college;Colorado;Communities;Data;Data Analyses;Data Collection;Data Coordinating Center;data science infrastructure;Data Set;data standards;Data Storage and Retrieval;Databases;Derivation procedure;Diabetes Mellitus;Diagnosis;Disease;disease model;DNA;endocrine pancreas development;Enrollment;Ensure;Etiology;Family;Family member;Florida;Functional disorder;Funding;Future;General Hospitals;Genes;genetic variant;genome sequencing;genomic data;Genotype;Goals;Grant;Health Sciences;human induced pluripotent stem cells;In Vitro;Indiana;Individual;Institutional Review Boards;interest;Investigation;Laboratories;Learning;Maryland;Massachusetts;Medicine;Metabolic;metabolomics;Methods;Michigan;monocyte;multiple omics;Newly Diagnosed;North Carolina;novel;Participant;Pathogenicity;Pediatric Hospitals;Phenotype;phenotypic data;Plasma;pluripotent stem cell differentiation;Pluripotent Stem Cells;precision medicine;preservation;proband;Protocols documentation;rare variant;Recording of previous events;Resources;RNA;Sampling;Signal Transduction;success;Testing;Tissues;transcriptome;transcriptome sequencing;transcriptomics;United States National Institutes of Health;Universities;Utah;Variant;variant of interest;Washington;whole genome

PROJECT_TITLE: Center for Identification and Study of Individuals with Atypical Diabetes Mellitus

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-9 (J1)]


NIH_SPENDING_CATS: Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

PI_NAMEs: PHILIPSON, LOUIS H. (contact)

PROJECT_TERMS: adjudication;Adverse event;Affect;Ancillary Study;Antibodies;Area;Beta Cell;cohort;Collaborations;Communication;Data;data access;Data Analyses;design;Diabetes Mellitus;Enrollment;Ensure;Expenditure;Functional disorder;Funding;genetic variant;Genome;Goals;health disparity;IGF1R gene;Individual;INSR gene;Institution;Insulin;Insulin deficiency;Laboratories;Lead;Leadership;Manuscripts;meetings;Modeling;Molecular;Non obese;operation;Outcome Study;Pathway interactions;Phenotype;Population;programs;Protocols documentation;Publications;recruit;Reporting;Resources;Review Committee;sample collection;Services;special interest group;Structure;success;System;Testing;Variant;web portal;web site

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Diabetes;Networking and Information Technology R&D (NITRD)

PI_NAMEs: WASSERFALL, CLIVE H (contact)

PROJECT_TERMS: biobank;Biological Specimen Banks;Case Report Form;Clinical Medicine;Communities;computerized data processing;Computerized Medical Records Systems;Data;Data Collection;data integration;Data Management Resources;data sharing;data standards;Databases;Development;Diabetes Mellitus;Diagnosis;Electronics;Environment;experience;Extensible Markup Language;Family;Future;Genomics;Goals;Guidelines;Health Personnel;Image;Individual;Institution;Internet;Laboratories;Manuals;metabolomics;Mitochondria;Modeling;National Institute of Diabetes and Digestive and Kidney Diseases;Object Relations;Ontology;participant enrollment;Persons;Pharmaceutical Preparations;Phenotype;Procedures;Programming Languages;Protocols documentation;repository;Research Personnel;RNA;Sampling;Services;Side;Software Design;System;Terminology;Testing;United States National Institutes of Health;Visit;web interface;web services

PROJECT_TITLE: Data and Repository Core


PROJECT_TERMS: adjudication;Age;Autoantibodies;Autoimmune;Categories;Cell model;Characteristics;Classification;Clinical;Confusion;Data;Databases;Descriptor;Diabetes Mellitus;Diagnosis;Diagnostic;diagnostic criteria;Disease;Drug Targeting;Elements;eligible participant;Enrollment;Etiology;falls;Family;Family member;Functional disorder;Funding;Genes;genetic variant;Genome;genome sequencing;Genomics;Genotype;Glucose;Goals;Human;Hyperglycemia;improved;Individual;induced pluripotent stem cell;Infrastructure;Insulin;Insulin deficiency;Insulin Resistance;Insulin-Dependent Diabetes Mellitus;lean body mass;loss of function mutation;Mediating;metabolomics;Modeling;Molecular;multidisciplinary;Mutation;neonatal diabetes mellitus;Non-Insulin-Dependent Diabetes Mellitus;Obesity;Participant;participant enrollment;Pathogenicity;Pathologic;Pathway interactions;Patients;personalized diagnostics;Persons;Phenotype;Physiological;Physiology;Plasma;Process;recruit;repository;Research Personnel;response;screening;segregation;Source;Structure of beta Cell of islet;Subgroup;Syndrome;T-Lymphocyte;Therapeutic;transcriptome;transcriptome sequencing;transcriptomics;Variant;whole genome;Work

PROJECT_TITLE: Discovery and Analysis Project


ORG_CITY: BRONX

ORG_NAME: JAMES J PETERS VA  MEDICAL CENTER

ORG_STATE: NY

PHR: Veterans are at higher risk than non-Veterans of falling ill with amyotrophic lateral sclerosis (ALS). As we await a cure for ALS in the future, we need more treatments now. We have shown that pairing electrical stimulation over the cervical spinal cord synchronized with magnetic stimulation over the brain can temporarily strengthen weakened nerve circuits between the brain and hand muscles in people with ALS. The current proposal will take the next step of customizing this intervention for each individual, then applying it repetitively in an attempt to achieve direct clinical benefit on hand strength and function. We will compare the effects of two-week programs of hand exercise versus paired brain-spinal stimulation versus the combination of exercise and stimulation. Not only will this project improve understanding of paired brain-spinal cord stimulation in ALS, but its eligibility criteria will also be more inclusive than most ALS studies, giving more Veterans an opportunity to participate in research aimed at treating this service-connected condition.

PI_NAMEs: HAREL, NOAM Y. (contact)

PROJECT_TERMS: ALS patients;Amyotrophic Lateral Sclerosis;Award;Biological Markers;Brain;Brain-Derived Neurotrophic Factor;Cervical;Cervical spinal cord structure;Cervical spine;Clinic;Clinical;Clinical Research;Clinical Trials;combinatorial;Data;design;dexterity;Disease;Dorsal;efficacy testing;Electric Stimulation;Electromyography;Eligibility Determination;excitotoxicity;Exclusion;Exercise;exercise intervention;exercise program;falls;Fatigue;Frequencies;Frustration;Funding;Future;Glutamates;grasp;Hand;Hand functions;Hand Strength;high risk;improved;Individual;Inflammation Mediators;Inflammatory;Intervention;Isometric Exercise;Knowledge;Light;Magnetism;Measures;Mediating;Methods;millisecond;Modality;Motor;Motor Evoked Potentials;Motor Neurons;Motor output;Muscle;Muscle Cramp;Nerve;Nerve Degeneration;neural circuit;neurofilament;neurological rehabilitation;Neuronal Plasticity;neurophysiology;neuroregulation;Neurostimulation procedures of spinal cord tissue;neurotropic;novel;novel strategies;Outcome;Pain;paired stimuli;Participant;Pathway interactions;Pattern;Persons;Phase;Physical Exercise;Physiologic pulse;Physiological;post intervention;primary outcome;programs;Randomized;Reproducibility;Research;respiratory;response;Rest;Safety;Serum;Services;spasticity;Spinal;Spinal Cord;Spinal cord injury;Stimulus;Symptoms;Synapses;Synaptic plasticity;Synaptic Transmission;Techniques;Testing;Time;Transcranial magnetic stimulation;Upper Extremity;Variant;Veterans

PROJECT_TITLE: Spinal Cord Associative Plasticity for Amyotrophic Lateral Sclerosis

STUDY_SECTION: RRDA

STUDY_SECTION_NAME: Spinal Cord Injury/Disorders & Neuropathic Pain[RRDA]


NIH_SPENDING_CATS: Cancer;Immunotherapy;Skin Cancer

ORG_CITY: MIAMI

ORG_NAME: FLORIDA INTERNATIONAL UNIVERSITY

ORG_STATE: FL

PHR: The overall objective of the grant is to understand how the melanoma glycome, which is the repertoire of cellular glycans and glycan-binding proteins, impacts metastatic progression. Our proposed studies seek to investigate whether a newly-described glycome pathway in metastatic melanoma cells is critical for melanoma metastasis and a potential target for effective anti-metastatic therapy. These findings will help illuminate the value of novel human melanoma glycome features as clinical biomarkers for diagnosing melanoma development or for prognosticating clinical outcome and treatment strategies.

PI_NAMEs: DIMITROFF, CHARLES J (contact)

PROGRAM_OFFICER_NAME: MERCER, NATALIA

PROJECT_TERMS: anti-cancer research;anti-CTLA4;anti-PD-1;anti-PD1 antibodies;Antitumor Response;Binding;Binding Proteins;Biological Markers;Biology;cancer therapy;CD44 gene;Cell Adhesion;Cell surface;Cells;checkpoint inhibition;Clinical;clinical biomarkers;Clinical Investigator;Data;design;Detection;Development;Diagnosis;Disease;Disease Progression;effective therapy;Effectiveness;Enhancers;Enzymes;Family member;Galactose Binding Lectin;Galectin 3;Glycoproteins;glycosylation;glycosyltransferase;Goals;Grant;Growth;Human;Human Activities;Hypoxia;Immune Evasion;Immunity;Immunotherapeutic agent;Immunotherapy;improved;in vivo;Incubated;innovation;Integrins;Investigation;Knockout Mice;Laboratories;Lectin;Ligands;Malignant - descriptor;Malignant Neoplasms;Mediating;Melanoma;melanoma biomarkers;Melanoma Cell;Melanoma patient;Melanoma Tumor;Metastatic Melanoma;Methods;Modeling;Molecular;Mus;N-Acetylglucosaminyltransferases;N-acetyllactosamine;Neoplasm Metastasis;new therapeutic target;NGFR Protein;novel;novel therapeutics;Oncogenic;Outcome;Pathologist;Pathway interactions;Patients;personalized medicine;Play;Polysaccharides;pre-clinical;predictive marker;Predisposition;Prognostic Marker;prognostication;programs;Publishing;receptor expression;Refractory;Relapse;Research;Research Personnel;Resistance;response;Role;Sampling;Serum;Signal Transduction;Staging;success;Survival Rate;therapeutic target;therapy resistant;Tissues;trait;treatment response;treatment strategy;tumor;tumor initiation;Tumor Promotion;Tumor Tissue;Up-Regulation;Xenograft procedure

PROJECT_TITLE: Analysis of galectin-8 and its ligands in melanoma progression

STUDY_SECTION: TEHM

STUDY_SECTION_NAME: Tumor Evolution, Heterogeneity and Metastasis Study Section[TEHM]


ORG_NAME: VA PUGET SOUND HEALTHCARE SYSTEM

PHR: Stable housing is fundamental to mental and physical health, and eviction represents a major source of housing instability. The national eviction moratorium imposed during the pandemic recently ended, and housing experts are expecting a surge of evictions in the coming years. This surge could substantially imperil progress toward VA’s objective to eliminate Veteran homelessness. The proposed study fills major gaps in our understanding of how evictions affect homelessness and health for Veterans.

PI_NAMEs: HEBERT, PAUL L. (contact)

PROJECT_TERMS: Address;adjudication;Affect;Appointment;Area;Awareness;Black race;Budgets;Caring;Case Management;Characteristics;Charge;Chicago;Chronic;Clinical;cohort;Collaborations;cooking;cost;County;court;COVID-19 pandemic;Data;Data Set;Databases;design;Educational workshop;Enrollment;Etiology;experience;Face;Family;Financial Support;flexibility;follow-up;Funding;Goals;Grant;Health;health care availability;Health Care Costs;Health Care Visit;health equity;Healthcare;Hispanic;Home;Homelessness;Household;Housing;housing instability;human centered design;improved;Indiana;Individual;innovation;Intervention;Interview;Link;Literature;Marketing;Mental Health;Mental Health Services;Methodology;Minnesota;Names;Natural Language Processing;novel;Online Systems;Outcome;Outpatients;outreach;pandemic disease;Patient Outcomes Assessments;Personal Satisfaction;Persons;physical conditioning;physical health service;pilot test;poor health outcome;predictive modeling;prevent;primary outcome;Probability;programs;prospective;Records;Research;Research Personnel;Risk;Risk Factors;risk minimization;screening;Services;social;social health determinants;Socioeconomic Status;socioeconomics;sound;Source;Statistical Data Interpretation;supported housing;Surveys;System;Time;U.S. Department of Housing and Urban Development;United States Department of Veterans Affairs;Veterans;Washington

PROJECT_TITLE: Reducing Evictions, Homelessness, and Poor Health Outcomes Among Washington State Veterans: Integrating Novel State Data into Analytic and Predictive Models of Housing Insecurity

STUDY_SECTION_NAME: HSR-3 Healthcare Informatics[HSR3]


ORG_CITY: HINES

ORG_NAME: EDWARD HINES JR VA HOSPITAL

PHR: Veterans living with spinal cord injury (SCI) experience devastating and costly pressure injuries (PrI) leading to preventable long hospitalizations and surgery. PrIs are local areas of damage to the skin and underlying soft tissue caused by pressure and shear commonly located over bony prominences. Veteran Health Administration (VA) SCI clinics provide an annual preventive care visit for Veterans living with SCI, but past research has shown that risks arise throughout the year requiring on-going preventive care. In collaboration with the VA SCI National Program Office and VA Office of Connected Care, this proposed implementation study will assess the efficacy and implementation of the new VA research- funded decision support tool, called the Community Acquired Pressure Injury Prevention Field Implementation Tool (CAPP-FIT) to prevent community-acquired PrIs at seven SCI outpatient clinics across the country to support and guide national implementation.

PI_NAMEs: BURKHART, ELIZABETH  (contact)

PROJECT_TERMS: Address;Adoption;Affect;Ambulatory Care Facilities;Applications Grants;Area;Behavioral;Caring;Client satisfaction;Clinic;Clinic Visits;Clinical;clinical practice;Collaborations;Communication;Communities;Companions;Complex;complex chronic conditions;connected care;Consultations;cost;Country;decubitus ulcer;Denervation;design;efficacy evaluation;Electronic Health Record;Electronic Mail;Elements;Environmental Risk Factor;Evaluation;evidence based guidelines;experience;Funding;Geography;Health;health assessment;health care service utilization;high risk;Home;Homogeneously Staining Region;Hospitalization;Hospitals;Hybrids;Immobilization;implementation barriers;implementation evaluation;implementation study;implementation tool;improved;Incidence;injury prevention;Intervention;Intuition;Life;Maintenance;Medical;modifiable risk;mortality;Motor;nerve damage;Numbness;Nursing Homes;Office Visits;Operative Surgical Procedures;Patients;Persons;Phase;pilot test;pressure;prevent;Prevention Guidelines;Preventive;Preventive care;Printing;Problem Solving;programs;Provider;psychosocial;Quality of life;Randomized;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Readiness;Recommendation;Reporting;Research;Resources;response;Risk;Risk Assessment;Risk Factors;satisfaction;Secure;Site;Skin;soft tissue;Spinal cord injury;Standardization;success;support tools;Surveys;tool;Training;Veterans;Veterans Health Administration;Visit;Voice

PROJECT_TITLE: Implementing a Decision Support Tool to prevent Community-Acquired Pressure injury in Spinal Cord Injury (SCI) in the Spinal Cord Injury Clinic.

STUDY_SECTION_NAME: HSR-5 Health Care System Organization and Delivery and Women's Health[HSR5]


ORG_CITY: NEW YORK

ORG_NAME: VA  MEDICAL CENTER

PHR: The project will investigate the efficacy of a Veteran-peer-navigator-led decision coaching (PDC) program to promote Shared Decision Making (SDM) for prostate cancer screening among Veterans at the Veterans Health Administration (VA). Prostate cancer is commonly screen detected using PSA, a non-specific test which has led to modest population-level survival benefits at the cost of over-detection of low-risk disease. This trade off in outcomes is ideally addressed using SDM which can be challenging to implement in time constrained primary care office visits. We propose the evaluation of a PDC intervention to promote SDM for PSA screening to improve both access and quality of care for Veterans. Our results will enhance understanding of the efficacy, cost-effectiveness, and sustainability of PDC interventions for SDM promotion across communication formats in the VA. Lessons learned through this proposal will not only improve quality of care for PSA screening but also will suggest a paradigm for dissemination of SDM across preventive services.

PI_NAMEs: MAKAROV, DANIL V. (contact)

PROJECT_TERMS: Accounting;Address;Administrator;Affect;Attitude;Behavior;black men;Black race;budget impact;cancer diagnosis;Clinic;Clinical;clinical practice;Communication;Community Healthcare;Conflict (Psychology);Consumption;cost;cost effectiveness;cost outcomes;Costs and Benefits;Counseling;Data;Decision Aid;Dedications;Detection;disorder risk;efficacy evaluation;efficacy testing;Ensure;Evaluation;experience;Future;Goals;group intervention;Health;health care delivery;health care service utilization;health equity promotion;Health system;Healthcare;Healthcare Systems;improved;innovation;Intervention;intervention cost;Intervention Studies;Interview;Knowledge;Malignant neoplasm of prostate;Malignant Neoplasms;Medical Care Team;member;men;Methodology;Methods;New York;novel;Office Visits;Outcome;Participant;Patient Care;patient-clinician communication;Patients;peer;Persons;Population;preventive intervention;Preventive service;Primary Care;primary care provider;Procedures;programs;Prostate-Specific Antigen;Provider;provider communication;PSA screening;Public Health;Qualitative Methods;Quality of Care;Race;Randomized;randomized trial;Recommendation;Records;Research Priority;Resources;Role;satisfaction;screening;Screening for Prostate Cancer;screening guidelines;Self Efficacy;shared decision making;standard of care;Structure;Surveys;System;telehealth;Testing;theories;Time;Training;United States;United States Preventative Services Task Force;Veterans;Veterans Health Administration;Weighing patient

PROJECT_TITLE: Randomized trial of Veteran peer navigators to promote Shared Decision Making for PSA screening

STUDY_SECTION_NAME: HSR-2 Behavioral, Social, and Cultural Determinants of Health and Care[HSR2]


ORG_DEPT: BIOCHEMISTRY

ORG_NAME: TUFTS UNIVERSITY BOSTON

PHR: NARRATIVE: OVERALL Persistent symptoms after treatment for Lyme disease occurs in a substantial proportion of people who get infected by the bacteria that causes this widespread tick-borne disease. The cause of the persistent symptoms is controversial but we believe that there are multiple factors that contribute to its development including prior or concurrent exposures to other organisms, immune abnormalities and specific traits of the infecting bacteria. This study will provide a broad investigation into multiple possible contributing factors in patients who are enrolled before it is known whether they will resolve their symptoms or have persistent symptoms in order to better understand how these symptoms develop, how to predict them and how to prevent or treat them.

PI_NAMEs: HU, LINDEN T (contact)

PROGRAM_OFFICER_NAME: BOWDEN, NADINE

PROJECT_TERMS: Acute;Aftercare;Agreement;Antibiotic Resistance;Area;Autoantibodies;Autoimmunity;Bacteria;Binding;Biological Specimen Banks;Biometry;Borrelia burgdorferi;Categories;cell type;Characteristics;Chronic;Clinical;clinical investigation;co-infection;cohort;Collaborations;Communities;Community Networks;Community of Practice;Complex;Consensus;Data;Development;Diagnosis;Diagnostic;Diagnostic tests;Disease;Enrollment;Entomology;Epidemiologist;Epidemiology;Event;experience;Exposure to;follow-up;Formulation;Future;Generations;Genetic;Genotype;Goals;Health;Human;Illusions;Immune;Immune response;Immunologics;Immunologist;Immunology;improved;Incidence;Inflammatory;Inflammatory Response;insight;Investigation;Long COVID;Lyme Disease;Lyme disease diagnosis;microbial;Microbiology;Minority;Modeling;Modernization;Nature;New England;new technology;North America;novel;novel marker;Order Spirochaetales;Organism;Outcome;participant enrollment;Pathogenesis;Pathogenicity;Patients;Pattern;Peptidoglycan;persistent symptom;Persons;Phenotype;Population;Post Treatment Lyme Disease Syndrome;Predictive Value;Prevalence;prevent;Prevention;preventive intervention;Process;programs;Property;prospective;Prospective Studies;Reaction;Recording of previous events;Reporting;Research;Research Personnel;Resources;Risk;Risk Factors;Role;rural area;sample collection;Sample Size;Sampling;Scientist;Study Subject;suburb;symptomatology;Symptoms;T-Lymphocyte;Technology;Testing;Therapeutic Intervention;Tick-Borne Diseases;tick-borne pathogen;Time;trait

PROJECT_TITLE: A Prospective Study of Persistent Symptoms of Lyme Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 MS-M (J1)]


NIH_SPENDING_CATS: Infectious Diseases;Lyme Disease;Tickborne Diseases;Vector-Borne Diseases

PHR: NARRATIVE: ADMINISTRATIVE CORE Crucial to any complex clinical study is coordination of all of the different parts of the team that need to function together to make the project a success. The Administrative Core will be in charge of overseeing the functioning of the project and ensuring that the different parts work well together and are communicating with each other. Communication between members of the Project as well as from the Project to the Public will use multiple different avenues including but not limited to regularly scheduled meetings/retreats, shared communication channels (e.g. Slack and group elists), social media and creation of a website.

PROJECT_TERMS: Academic Medical Centers;Achievement;Area;Charge;Clinical;Clinical Research;Communication;Communities;Complex;data exchange;design;Diagnostic;Diagnostic Trial;Disease;Enrollment;Ensure;Evaluation;Evaluation Reports;experience;Faculty;Feedback;Future;Goals;Health;Human;Human Resources;improved;Individual;Infection;Information Dissemination;Infrastructure;Institution;Knowledge;Lead;Leadership;Lyme Disease;medical schools;meetings;member;Microbiology;Misinformation;Mission;Modeling;Molecular Biology;multimodality;National Institute of Allergy and Infectious Disease;New England;Newly Diagnosed;Occupational activity of managing finances;Participant;Patients;persistent symptom;Post Treatment Lyme Disease Syndrome;Process;Productivity;programs;Progress Reports;prospective;Prospective Studies;Protocols documentation;Public Health;Publications;Recommendation;Recording of previous events;recruit;Regulation;Reporting;Research;Research Personnel;Resolution;Resource Sharing;Resources;Role;Sampling;Schedule;Seminal;social media;success;symposium;Symptoms;synergism;Tilia;Training;treatment trial;United States National Institutes of Health;Universities;vaccine trial;web site;Work


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Infectious Diseases;Lyme Disease;Tickborne Diseases;Vector-Borne Diseases

PHR: NARRATIVE: CLINICAL COORDINATION CORE Persistent symptoms following antibiotic treatment for early Lyme disease cause debilitating illness in some patients. The CCC is designed to support a series of research projects targeted to determine the causes of persistent symptoms in Lyme disease. It will accomplish this goal by enrolling the largest number of persons with early Lyme disease ever studied in North America and by ensuring that the clinical information and research samples needed to answer the questions about the causes of persistent symptoms are available to be analyzed by leading scientists using state of the art technologies.

PI_NAMEs: SMITH, ROBERT PEASE (contact)

PROJECT_TERMS: Acute;Address;Anaplasma phagocytophilum;Antibiotic Therapy;Antibodies;Area;Arthralgia;biobank;Biological;Biological Markers;biomarker identification;Black-legged Tick;Blood;Blood specimen;Borrelia burgdorferi;Borrelia miyamotoi;brain fog;Carditis;care providers;Clinical;Clinical Data;clinical database;Clinical Management;Clinical Research;clinical research site;cohort;Collaborations;Collection;Data;Data Management Resources;Databases;design;Diagnostic;Disease;Early treatment;Enrollment;Ensure;erythema migrans;experience;Exposure to;Fatigue;follow-up;Future;Generations;Geographic Distribution;Geographic Locations;Goals;Growth;high risk;Hospitals;Immunologic Markers;Impaired cognition;Incidence;Infrastructure;Institution;Investigation;Leadership;Length;Link;Lyme Disease;Maine;Massachusetts;Medical;medical schools;meetings;Meningitis;Mental Health;Molecular;Monitor;Myalgia;Neurologic;New England;North America;operation;organizational structure;Outpatients;participant enrollment;Pathogenesis;patient population;Patients;persistent symptom;Persons;physical conditioning;Population;Post Treatment Lyme Disease Syndrome;Powassan virus;Practice Management;Prevalence Study;Primary Care;programs;prospective;Prospective Studies;Protocols documentation;Recording of previous events;Research;Research Personnel;Research Project Grants;Resolution;Resources;sample collection;Sample Size;Sampling;Scientist;Series;seropositive;serosurvey;SF-36;Site;skin biopsy;Specific qualifier value;Specimen;Specimen Handling;Structure;Surveys;Symptoms;Syndrome;Systems Integration;Technology;Testing;tick transmission;Tick-Borne Infections;tick-borne pathogen;Time;Tissue Sample;Tissues;Universities;urgent care;Urine;Venous blood sampling;Visit;Work

PROJECT_TITLE: Clinical Coordination Core


NIH_SPENDING_CATS: Clinical Research;Emerging Infectious Diseases;Hematology;Infectious Diseases;Lyme Disease;Machine Learning and Artificial Intelligence;Tickborne Diseases;Vector-Borne Diseases

PHR: NARRATIVE: Diagnostic Core Crucial to any groundbreaking study of PTLDS will be the availability of properly collected and stored human samples obtained from well-characterized patients with Lyme disease and control subjects. The Diagnostics Core will assist in comprehensive subject characterization by performing a predefined battery of laboratory diagnostic tests on each enrolled subject, the results of which will be correlated with clinical findings. We will also develop and maintain a biorepository of archived human samples from each well-characterized subject, for use by the project investigators to support research aims.

PI_NAMEs: BRANDA, JOHN  (contact)

PROJECT_TERMS: Adherence;adjudication;Aliquot;Antibodies;Antibody Response;Anticoagulation;Archives;Artificial Intelligence;Bayesian Analysis;biobank;Biological Assay;Biopsy Specimen;Blood specimen;Blood Tests;Borrelia;Chemistry;CLIA certified;Clinical;clinical care;Clinical Microbiology;clinical research site;cohort;cold temperature;Complement;Data;Data Analyses;data integration;Data Set;Decision Theory;Development;Diagnostic;Diagnostic Procedure;Diagnostic Reagent Kits;Diagnostic tests;Edetic Acid;Enrollment;Ensure;erythema migrans;Evaluation;experience;Experimental Designs;falls;Freezing;General Hospitals;Goals;Hematology;Human;human subject;Immunoglobulin M;Individual;Infectious Agent;Investigation;Ixodes;Laboratories;Lesion;Lyme Disease;Machine Learning;Maps;Massachusetts;metagenomic sequencing;Methodology;Methods;Modeling;Pathogen detection;Patients;Performance;Peripheral Blood Mononuclear Cell;persistent symptom;Plasma;Positioning Attribute;Post Treatment Lyme Disease Syndrome;Powassan virus;predictive modeling;Procedures;Process;programs;prospective;Prospective Studies;Protocols documentation;Rectum;Reproducibility;Research;Research Personnel;Research Support;Running;Sampling;Serology;Serum;Services;skin biopsy;Standardization;Swab;System;Test Result;Testing;tick-borne;Tick-Borne Infections;Urine;Visit;Whole Blood

PROJECT_TITLE: Diagnostics Core


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Burden of Illness;Clinical Research;Emerging Infectious Diseases;Infectious Diseases;Lyme Disease;Pain Research;Prevention;Tickborne Diseases;Vector-Borne Diseases

PHR: NARRATIVE: Project 1, The Epidemiology of Post-Treatment Lyme Disease Syndrome The proposed project ultimately seeks to provide a biological basis for preventing and treating Post Treatment Lyme Disease Syndrome (PTLDS) by analyzing risk factors, particularly coinfections, within residents of deer tick-exposed communities. In addition, we shall place its health burden into context by comparison with that of well studied similar conditions, providing a metric for evaluating intervention methods.

PI_NAMEs: TELFORD, SAM R (contact)

PROJECT_TERMS: Acute;Address;allodynia;Anaplasmosis;Antibiotics;Autoantibodies;Babesiosis;Biological;Black-legged Tick;Borrelia burgdorferi;Borrelia miyamotoi;Categories;Chronic Disease;Chronic Fatigue Syndrome;Clinical;clinical risk;co-infection;cohort;Cohort Studies;Communities;comorbidity;debilitating symptom;Development;Diagnosis;Diagnostic;disability-adjusted life years;Disease;Early treatment;Elements;Endemic Diseases;Enrollment;Epidemiology;experience;Exposure to;flea-borne;Goals;Health;Human;Hyperalgesia;Immune;Incidence;Infection;interest;Intervention;Investigation;Irritable Bowel Syndrome;Knowledge;Literature;Lyme Disease;Measures;Methods;Modality;Morbidity - disease rate;mosquito-borne;Multiple Chemical Sensitivity;New England;Patients;persistent symptom;Positioning Attribute;Post Treatment Lyme Disease Syndrome;Powassan virus;prevent;programs;prospective;Prospective Studies;Public Health;Questionnaires;Recovery;Regimen;Reporting;Research;Resolution;Risk;Risk Factors;Role;Sampling;serosurvey;Site;Standardization;Symptoms;Syndrome;Tick Infestations;tick transmission;tick-borne;Tick-Borne Diseases;Tick-Borne Infections;Ticks;Time;transmission process;vector-borne infection;Work;Zoonoses


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Genetics;Infectious Diseases;Lyme Disease;Tickborne Diseases;Vector-Borne Diseases

PHR: NARRATIVE: Project 2, Immunology of Post-treatment Lyme Disease Syndrome The human immune response plays an important role in protecting us from disease but can also cause disease when not responding properly. In this Project, we will use new technologies to identify how immune responses may differ between people who recover from Lyme disease versus those who have persistent symptoms. Understanding the differences may lead us to new diagnostics and strategies for treating people with persistent symptoms after treatment.

PROJECT_TERMS: Acute;Acute-Phase Proteins;Aftercare;Alleles;Antibodies;Antibody Response;Antigens;Autoantibodies;Autoantigens;Autoimmune Diseases;Autoimmunity;autoreactive T cell;bacterial genetics;Binding;Bioinformatics;Biological Assay;Borrelia burgdorferi;candidate identification;Categories;CCL19 gene;CD8B1 gene;cell type;chemokine;Chronic Fatigue Syndrome;Clinical;cohort;Communicable Diseases;cytokine;Data;Development;Diagnostic;Disease;Fatigue;Fibromyalgia;Flow Cytometry;Gene Expression;Gene Expression Profile;Genes;Genetic;Goals;high dimensionality;HLA-DR Antigens;Human;Human Genetics;Immune;immune activation;Immune response;Immune system;Immunity;Immunologics;Immunology;Immunoprecipitation;Infection;Inflammatory;inflammatory marker;Inflammatory Response;Interferon alpha;interleukin-23;Joints;Lead;Libraries;Link;Long COVID;Lyme Arthritis;Lyme Disease;Mass Spectrum Analysis;Measurement;Memory Loss;Methods;Modeling;multimodal modeling;Myalgia;nano-liquid chromatography;neural;Neurons;new technology;novel diagnostics;novel marker;pathogen;Pathway interactions;patient response;Patients;Peptides;persistent symptom;Persons;Phage Display;Phospholipids;Play;Positioning Attribute;Post Treatment Lyme Disease Syndrome;Predisposition;Production;prospective;Prospective Studies;protein expression;receptor;Regulation;Regulatory T-Lymphocyte;response;Role;Sampling;screening;Serum;Stimulus;Symptoms;Syndrome;T cell response;T-Lymphocyte;tandem mass spectrometry;Technology;Testing;Tissues;transcriptome sequencing

PROJECT_TITLE: Immunology of Post-Treatment Lyme Disease Syndrome


ORG_CITY: NEW HAVEN

ORG_DEPT: GENETICS

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it will help explain why even the strongest environmental and genetic risk factors have variable effects across individuals, and enable prediction of these differences in response. A specialized mouse model will be used to determine if preexisting epigenetic risk leaves a detectable signature in tumors. Defining such a signature will guide diagnosis and personalized treatment for future cancer patients.

PI_NAMEs: LESCH, BLUMA J (contact)

PROGRAM_OFFICER_NAME: MARQUEZ, GUILLERMO

PROJECT_TERMS: Adult;Alleles;Animal Model;Biological Assay;cancer diagnosis;Cancer Patient;cancer risk;cancer therapy;Cells;Chromatin;Classification;Clinic;comparison control;Control Animal;Development;Diagnosis;DNA Methylation;driver mutation;early onset;Embryo;Embryonic Development;Ensure;Environmental Risk Factor;epigenetic marker;Epigenetic Process;epigenomics;Experimental Models;Future;Gene Abnormality;Gene Expression;Genetic;genetic risk factor;genetic signature;Genetic Transcription;genome-wide;Germ Lines;Histologic;histone modification;Human;improved;Individual;individualized medicine;Inherited;KRAS2 gene;KRASG12D;Life;Lung;Lung Neoplasms;lung tumorigenesis;Malignant neoplasm of lung;Malignant Neoplasms;Memory;Methods;Modeling;Molecular;molecular phenotype;Molecular Profiling;mouse model;Mus;mutant;Mutation;Normal tissue morphology;novel marker;offspring;Oncogenic;Outcome;Pathway interactions;patient population;Patients;personalized medicine;Phenotype;Population;predicting response;Prediction of Response to Therapy;Predisposition;Prevention;Public Health;Recording of previous events;Reproducibility;Research;Residual state;response;Risk;Risk Factors;risk prediction;risk stratification;screening;Smoker;Structure of parenchyma of lung;targeted treatment;Testing;Tissues;tumor;Tumor Burden;tumor growth;tumor initiation;tumor progression;tumorigenesis;Work

PROJECT_TITLE: Defining signatures of epigenetic sensitization to lung cancer in a mouse model

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 RTRB-S (J1)]


ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because the results from this project will improve risk stratification of thyroid nodules using genetic data, reduce the number of invasive thyroid fine needle aspiration biopsies, and decrease the burden of a thyroid cancer diagnosis on patients and the healthcare system in the United States. Thus, the proposed research is relevant to the NIH’s mission of fostering innovative research strategies and their applications as a basis for ultimately protecting and improving health.

PI_NAMEs: GIGNOUX, CHRISTOPHER R;POZDEYEV, NIKITA  (contact)

PROGRAM_OFFICER_NAME: WANG, WENDY

PROJECT_TERMS: Adoption;Algorithms;American College of Radiology;Area;Benign;biobank;Biopsy;cancer biomarkers;cancer diagnosis;Cancer Family;cancer risk;Cancerous;Categories;Clinical;Clinical Trials;clinically relevant;cohort;Colorado;Cytology;Data;Databases;Detection;Diagnosis;diagnostic biomarker;Disease;efficacy evaluation;Endocrine;Evaluation;Female;Fine needle aspiration biopsy;Fostering;Future;General Population;Genetic;genetic architecture;genetic association;Genetic Risk;Genetic study;genetic testing;genome wide association study;genotyped patients;Germ Lines;Goals;Goiter;Health;Healthcare Systems;Heritability;Image;imaging study;improved;Incidence;Information Systems;innovation;Malignant - descriptor;Malignant neoplasm of thyroid;Malignant Neoplasms;Meta-Analysis;Methods;Mission;Nodular Goiter;Nodule;novel;Papillary thyroid carcinoma;Patients;personalized management;personalized medicine;phenome;Phenotype;Physical Examination;Physicians;polygenic risk score;Predisposition;Procedures;Public Health;Reporting;Research;Risk;Risk Estimate;risk stratification;ROC Curve;simulation;standard of care;statistics;System;Testing;Thyroid Gland;Thyroid Nodule;ultrasound;United States;United States National Institutes of Health;Variant

PROJECT_TITLE: Genetic architecture of thyroid cancer and its clinical utility

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 TCRB-J (J2)]


ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PI_NAMEs: BALASUBRAMANYAM, ASHOK  (contact);KRISCHER, JEFFREY P

PROJECT_TERMS: Address;Autoantibodies;Biochemical;Biological;Biological Markers;Biological Specimen Banks;candidate identification;Case Study;causal variant;Cell Physiology;Chicago;Classification;Clinical;clinical center;clinical practice;Collection;college;Colorado;Communities;Data;Data Analyses;Data Collection;Data Coordinating Center;data science infrastructure;Data Set;data standards;Data Storage and Retrieval;Databases;Derivation procedure;Diabetes Mellitus;Diagnosis;Disease;disease model;DNA;endocrine pancreas development;Enrollment;Ensure;Etiology;Family;Family member;Florida;Functional disorder;Funding;Future;General Hospitals;Genes;genetic variant;genome sequencing;genomic data;Genotype;Goals;Grant;Health Sciences;human induced pluripotent stem cells;In Vitro;Indiana;Individual;Institutional Review Boards;interest;Investigation;Laboratories;Learning;Maryland;Massachusetts;Medicine;Metabolic;metabolomics;Methods;Michigan;monocyte;multiple omics;Newly Diagnosed;North Carolina;novel;Participant;Pathogenicity;Pediatric Hospitals;Phenotype;phenotypic data;Plasma;pluripotent stem cell differentiation;Pluripotent Stem Cells;precision medicine;preservation;proband;Protocols documentation;rare variant;Recording of previous events;Resources;RNA;Sampling;Signal Transduction;success;Testing;Tissues;transcriptome;transcriptome sequencing;transcriptomics;United States National Institutes of Health;Universities;Utah;Variant;variant of interest;Washington;whole genome

PROJECT_TITLE: RARE and Atypical Diabetes Network(RADIANT)


NIH_SPENDING_CATS: Diabetes

PI_NAMEs: BALASUBRAMANYAM, ASHOK  (contact)

PROJECT_TERMS: adjudication;Adverse event;Affect;Ancillary Study;Antibodies;Area;Beta Cell;cohort;Collaborations;Communication;Data;data access;Data Analyses;design;Diabetes Mellitus;Enrollment;Ensure;Expenditure;Functional disorder;Funding;genetic variant;Genome;Goals;health disparity;IGF1R gene;Individual;INSR gene;Institution;Insulin;Insulin deficiency;Laboratories;Lead;Leadership;Manuscripts;meetings;Modeling;Molecular;Non obese;operation;Outcome Study;Pathway interactions;Phenotype;Population;programs;Protocols documentation;Publications;recruit;Reporting;Resources;Review Committee;sample collection;Services;special interest group;Structure;success;System;Testing;Variant;web portal;web site


PI_NAMEs: YOUNG, KENNETH  (contact)

PROJECT_TERMS: biobank;Biological Specimen Banks;Case Report Form;Clinical Medicine;Communities;computerized data processing;Computerized Medical Records Systems;Data;Data Collection;data integration;Data Management Resources;data sharing;data standards;Databases;Development;Diabetes Mellitus;Diagnosis;Electronics;Environment;experience;Extensible Markup Language;Family;Future;Genomics;Goals;Guidelines;Health Personnel;Image;Individual;Institution;Internet;Laboratories;Manuals;metabolomics;Mitochondria;Modeling;National Institute of Diabetes and Digestive and Kidney Diseases;Object Relations;Ontology;participant enrollment;Persons;Pharmaceutical Preparations;Phenotype;Procedures;Programming Languages;Protocols documentation;repository;Research Personnel;RNA;Sampling;Services;Side;Software Design;System;Terminology;Testing;United States National Institutes of Health;Visit;web interface;web services


PROJECT_TERMS: adjudication;Age;Autoantibodies;Autoimmune;Categories;Cell model;Characteristics;Classification;Clinical;Confusion;Data;Databases;Descriptor;Diabetes Mellitus;Diagnosis;Diagnostic;diagnostic criteria;Disease;Drug Targeting;Elements;eligible participant;Enrollment;Etiology;falls;Family;Family member;Functional disorder;Funding;Genes;genetic variant;Genome;genome sequencing;Genomics;Genotype;Glucose;Goals;Human;Hyperglycemia;improved;Individual;induced pluripotent stem cell;Infrastructure;Insulin;Insulin deficiency;Insulin Resistance;Insulin-Dependent Diabetes Mellitus;lean body mass;loss of function mutation;Mediating;metabolomics;Modeling;Molecular;multidisciplinary;Mutation;neonatal diabetes mellitus;Non-Insulin-Dependent Diabetes Mellitus;Obesity;Participant;participant enrollment;Pathogenicity;Pathologic;Pathway interactions;Patients;personalized diagnostics;Persons;Phenotype;Physiological;Physiology;Plasma;Process;recruit;repository;Research Personnel;response;screening;segregation;Source;Structure of beta Cell of islet;Subgroup;Syndrome;T-Lymphocyte;Therapeutic;transcriptome;transcriptome sequencing;transcriptomics;Variant;whole genome;Work

PROJECT_TITLE: RADIANT


ED_INST_TYPE: GRADUATE SCHOOLS

ORG_CITY: Princeton

ORG_DEPT: NEUROSCIENCES

ORG_NAME: PRINCETON UNIVERSITY

ORG_STATE: NJ

PHR: A variety of mental health conditions can be considered disorders of generalization, e.g., overgeneralization in anxiety and compulsion, and undergeneralization in schizophrenia. Latent cause inference is a fundamental cognitive process that lies at the heart of how we set generalization boundaries in perception, learning and decision making. We propose a comprehensive characterization of individual differences in latent cause inference and their relationship to self-reported symptom dimensions and clinical categories, as well as their underlying neural circuitry, proposing latent cause inference as a new RDoC dimension.

PI_NAMEs: NIV, YAEL  (contact)

PROJECT_TERMS: addiction;Amygdaloid structure;Animals;Anxiety;Anxiety Disorders;Area;behavior test;Behavioral;behavioral study;Brain;Categories;Classification;Clinic;Clinical;Clinical assessments;Clinical Research;clinically relevant;Cognition;Cognitive;cognitive process;Collaborations;Communication;compulsion;Computer Analysis;Computer Models;Data;data analysis pipeline;Data Collection;data harmonization;data sharing;Decision Making;density;Diagnostic;Diagnostics Research;Dimensions;Disease;drug misuse;Drug usage;Ensure;Environment;Evaluation;Event;experience;Explosion;Failure;genetic manipulation;Health;Heart;high resolution imaging;Hippocampus;Human;Human Resources;hypocretin;Image;Individual Differences;Infrastructure;interest;Interview;Investigation;knowledge integration;Learning;Loudness;Maps;Measurement;Measures;Memory;memory retrieval;Mental Depression;Mental disorders;Mental Health;Methods;Modeling;Motivation;National Institute of Mental Health;neural;neural circuit;Neurocognitive;neuroimaging;neuromechanism;Neurons;novel;novel strategies;Obsessive-Compulsive Disorder;outreach;Patient Self-Report;Perception;Post-Traumatic Stress Disorders;Process;Productivity;programs;Psychiatry;Psychoses;Rain;Rattus;Recording of previous events;recruit;Research;Research Domain Criteria;Research Personnel;Resistance;Resource Sharing;Rewards;Rodent;Role;Running;Sampling;Schizophrenia;Site;social;sound;Source;Standardization;Symptoms;Testing;tool;training project;Update;Variant;Work

PROJECT_TITLE: Conte Center: Understanding Latent Cause Inference in Health and Illness


NIH_SPENDING_CATS: Mental Health;Neurosciences

PROJECT_TERMS: Brain;Budgets;Clinical;Code;Cognitive;Collaborations;Communication;Communities;Computer Models;Consult;Data;Data Analyses;data archive;data exchange;data hub;data sharing;Development;Diagnostic;Dimensions;Education and Outreach;experimental study;Fostering;General Population;Goals;Grant;Health;Heart;Human;human subject;Individual Differences;Infrastructure;Institution;Investigation;Joints;Link;Maintenance;Maps;meetings;Mental disorders;mental function;Mental Health;multidisciplinary;National Institute of Mental Health;neural;neuropsychiatry;open data;outreach;Paper;Postdoctoral Fellow;Process;programs;Progress Reports;Publishing;Recording of previous events;Reporting;repository;Research;Research Assistant;Research Personnel;Resource Sharing;Resources;Rodent;Sampling;Secure;Structure;Students;success;Symptoms;synergism;System;Testing;Training Programs;translational approach;undergraduate research experience;Universities;videoconference;web site;Work

PROJECT_TITLE: Administrative Core (A)


NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Neurosciences;Schizophrenia;Serious Mental Illness

PROJECT_TERMS: addiction;Anxiety;Anxiety Disorders;Behavioral;Biological Markers;Brain;Categories;Classification;Clinical;cognitive function;cognitive process;compulsion;Computer Models;Core Facility;Data;Data Set;design;Diagnosis;Diagnostic;Dimensions;Disease;Environment;Evaluation;Event;experience;experimental study;Extinction;Functional Magnetic Resonance Imaging;General Population;generalized anxiety;Goals;Health;Heart;Hippocampus;Human;Impairment;Individual;Individual Differences;Knowledge;Laboratories;Learning;Maps;Measurement;Measures;Memory;Mental disorders;Mental Health;Methods;Microbe;Modeling;movie;National Institute of Mental Health;neural;Neurophysiology - biologic function;novel;Obsessive-Compulsive Disorder;Outcome;Patient Self-Report;Patients;Pattern;Perception;Persons;Phenotype;Population;predictive modeling;preference;prevent;Process;Psychopathology;Reading;recruit;research clinical testing;Research Domain Criteria;Resistance;response;Rewards;Running;Sampling;Schizophrenia;Severities;Shapes;Stimulus;Stream;symptomatology;Symptoms;task analysis;Testing;Time;translational potential;Update;Work

PROJECT_TITLE: Project 1: Latent-cause inference as a fundamental cognitive process


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Neurosciences;Substance Misuse

PI_NAMEs: ZALD, DAVID HAROLD (contact)

PROJECT_TITLE: Project 2: Latent-cause inference in compulsivity


NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Neurosciences

PI_NAMEs: NORMAN, KENNETH A (contact)

PROJECT_TERMS: Amygdaloid structure;Anxiety;Anxiety Disorders;anxiety symptoms;Architecture;Association Learning;aversive conditioning;Behavior;Behavioral;behavioral phenotyping;Biological Markers;biomarker identification;Brain;brain based;Clinical;Cognitive;cognitive function;computational basis;computer framework;computing resources;connectome;Coupled;Data;Development;Diagnosis;Diagnostic;Dimensions;Distant;Evidence based treatment;Exhibits;experience;Extinction;Failure;flexibility;Fright;Functional Magnetic Resonance Imaging;General Population;Generalized Anxiety Disorder;Goals;Health;Hippocampus;Imaging technology;improved;Individual;Individual Differences;individual variation;individuals with autism spectrum disorder;Intervention;Laboratory Study;Learning;Link;Maps;Measures;Mediating;member;Memory;Mental Health;Methods;Modeling;neural;neural correlate;Neurocognitive;neurofeedback;Neurophysiology - biologic function;Outcome;Participant;Patient Self-Report;Pattern;Performance;Phase;Phenotype;Phobias;predictive modeling;Process;Psychopathology;Recovery;Relapse;relapse prevention;Rest;Retrieval;Rewards;Running;Safety;Sampling;social anxiety;Structure;support network;Symptoms;System;Testing;Time;tool;treatment of anxiety disorders;Update;Work

PROJECT_TITLE: Project 3: Latent-cause inference in anxiety


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences

PI_NAMEs: WITTEN, ILANA  (contact)

PROJECT_TITLE: Project 4: Neural mechanisms underlying latent-cause inference


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Neurosciences;Substance Misuse

PI_NAMEs: KONOVA, ANNA BORISOVA (contact)

PROJECT_TERMS: Address;alcohol use disorder;Animals;Anxiety;Attention;behavior test;Behavioral;behavioral health;behavioral study;Categories;Characteristics;Clinical;Clinical assessments;Clinical Research;Cognitive;cognitive ability;cognitive task;Collection;Computer software;Consult;Consultations;Custom;Data;Data Collection;data modeling;data quality;Decision Making;Dedications;Development;Differential Diagnosis;Dimensions;DSM-V;eligible participant;Ensure;Ethics;Event;experimental study;Extinction;Foundations;Future;Goals;Guidelines;handheld mobile device;Health;Human;Human Subject Research;inclusion criteria;Individual;Individual Differences;Infrastructure;Instruction;instrument;Intelligence;interest;Interview;Joints;Learning;light weight;Lived experience;Longitudinal Studies;Measures;Mental disorders;Mental Health;Modeling;Monitor;neuropsychiatry;Participant;Patient Self-Report;Persons;Phenotype;Population Heterogeneity;Process;programs;prospective;Protocols documentation;Psychiatry;Psychometrics;Psychopathology;Quality Control;Questionnaires;recruit;Registries;remote grading;Remote session;Reproducibility;Research;research clinical testing;research study;Resources;Running;Sampling;Sampling Studies;Schizophrenia;screening;Secure;Shapes;Short-Term Memory;social media;software development;Standardization;Symptoms;Testing;Time;tool;Training;web site;Work

PROJECT_TITLE: Behavioral Testing and Clinical Assessment Core (B)


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Mental Health;Networking and Information Technology R&D (NITRD)

PI_NAMEs: DAW, NATHANIEL DOUGLASS (contact)

PROJECT_TERMS: Address;Animals;Anxiety;Behavior;Behavior Control;Behavioral;Brain;Clinical;Cognitive;Collaborations;comorbidity;Complex;computer framework;Computer Models;Computer software;coping;craving;Data;Data Analyses;Data Set;Decision Making;Dimensions;Ensure;Event;experience;Experimental Designs;Experimental Models;experimental study;Factor Analysis;Fright;Functional disorder;Functional Magnetic Resonance Imaging;Goals;Health;Human;improved;Individual;Infrastructure;innovation;insight;interest;Learning;Light;Measurement;Mental Depression;Mental disorders;Methodology;Methods;model building;model development;Modeling;Modernization;Motivation;multimodality;neural;Neurosciences;Parameter Estimation;Patient Self-Report;Pattern;Process;psychiatric symptom;Psychiatry;Psychopathology;Records;Reproducibility;Rest;Series;Severities;Statistical Models;Stimulus;Structure;Symptoms;Techniques;temporal measurement;Testing;theories;tool;Update;Variant;Work

PROJECT_TITLE: Computational Modeling Core (C)


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Data Science;Mental Health;Networking and Information Technology R&D (NITRD);Neurosciences

PROJECT_TERMS: advanced analytics;Amygdaloid structure;Archives;Behavior;Behavioral Model;Brain;Brain imaging;Brain region;Characteristics;Clinical;Communication;Computer Models;Computer software;Data;data acquisition;Data Analyses;data archive;Data Collection;data harmonization;data management;data quality;Data Set;data sharing;data structure;Dedications;Development;Doctor of Philosophy;Dropout;Education;Educational workshop;Ensure;Functional Magnetic Resonance Imaging;Goals;Health;High Performance Computing;Hippocampus;Human;Image;improved;Infrastructure;insight;large-scale imaging data;Location;Magnetic Resonance Imaging;Magnetism;member;Mental Health;Methodology;Methods;Mind;Multivariate Analysis;National Institute of Mental Health;neural;neural correlate;neurofeedback;neuroimaging;Neurosciences;open data;Participant;Patients;Pattern;Play;Population;predictive modeling;Prefrontal Cortex;preservation;prisma;Process;Publishing;Quality Control;Recording of previous events;Reproducibility;Research;Rest;Role;Scanning;Signal Transduction;Site;Standardization;Technical Expertise;Techniques;Testing;Time;Training;Universities

PROJECT_TITLE: Neuroimaging Core (D)


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Disability Research

ORG_CITY: SAN ANTONIO

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF TEXAS SAN ANTONIO

PHR: Increasing the number of researchers from scientifically-underrepresented groups will promote biomedical advancement in the United States. The proposed ESTEEMED Research Program will identify high-achieving underrepresented freshmen and support them as they develop as biomedical scientists. The students will engage in meaningful year-round biomedical research projects; receive mentoring, academic assistance, and personal and professional development trainings; and develop the credentials needed to enter UTSA’s MARC Honors Research Training Program as juniors, and later complete biomedical doctoral degrees and attain leadership positions in the scientific community.

PI_NAMEs: ABU-LAIL, NEHAL IBRAHIM (contact)

PROGRAM_OFFICER_NAME: GATLIN, TINA L

PROJECT_TERMS: Academic achievement;academic program;Academic support;Achievement;Address;Admission activity;Authorship;Award;Bachelor's Degree;Basic Science;Biomedical Engineering;biomedical imaging;Biomedical Research;biomedical scientist;bridge program;career;Career Choice;CCL7 gene;Censuses;Chemical Engineering;Classification;cohort;college;Communication;Communities;Computers;Credentialing;Degree Completion;design;Development;Development Plans;disability;Disabled Persons;Diverse Workforce;Doctor of Philosophy;Doctor's Degree;Education;education research;Educational Curriculum;Educational workshop;Engineering;Ethnic Origin;evidence base;experience;Extramural Activities;Faculty;field trip;Foundations;Funding;Future;Goals;Growth;Healthcare;Hispanic;Hispanic Populations;Hispanic-serving Institution;Individual;insight;interest;Intervention;Laboratories;Laboratory Research;Leadership;leadership development;lectures;Letters;Libraries;matriculation;Measurable;Measures;Medical Device Designs;Mentors;Minority;Minority Participation;Monitor;National Institute of Biomedical Imaging and Bioengineering;next generation;Oral;Outcome;outreach;Paper;peer coaching;Population;Population Heterogeneity;Positioning Attribute;programs;Publications;Published Comment;Publishing;Race;recruit;Reporting;Research;Research Activity;Research Personnel;Research Project Grants;Research Support;Research Training;Role;role model;Running;Science;Scientist;Self Efficacy;skills;Students;Study Skills;success;summer program;summer research;symposium;Talents;Technology;Texas;Time;Training;Training Programs;tutoring;undergraduate research;undergraduate student;Underrepresented Minority;Underrepresented Populations;Underrepresented Students;United States;United States National Academy of Sciences;Universities;Update;Vision;Washington;Woman;Writing

PROJECT_TITLE: UTSA ESTEEMED Program

STUDY_SECTION_NAME: Special Emphasis Panel[ZEB1 OSR-G (J1)]


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Social Determinants of Health

ORG_CITY: BATON ROUGE

ORG_NAME: LOUISIANA STATE UNIV A&M COL BATON ROUGE

ORG_STATE: LA

PHR: LSU ESTEEMED Scholars Project Narrative  The LSU ESTEEMED Scholars program will address the critical need for individuals from underrepresented groups in biomedical sciences and bioengineering. Given that we lose students out of biomedical/bioengineering education pathways early in their undergraduate studies, we must target interventions at this level to build a strong, multicultural, and diverse biomedical and scientific research workforce. To that end, the LSU ESTEEMED Scholars program targets high-potential students at the first-year (freshman) and second-year (sophomore) levels of undergraduate study, integrates them early into a biomedical research training ecosystem that cultivates their talents through holistic, student-centered approaches and prepares them for PhDs and MD/PhDs in biomedical science and bioengineering.

PI_NAMEs: WILSON-KENNEDY, ZAKIYA  (contact)

PROJECT_TERMS: Academic support;Acute;Advisory Committees;Award;Biology;Biomedical Engineering;Biomedical Research;Black race;career;career development;Chemistry;cohort;Communities;curriculum development;Data Science;design;Development;Development Plans;disabled;Disabled Persons;Discipline;Doctor of Medicine;Doctor of Philosophy;Ecosystem;education pathway;Educational workshop;Engineering;Enrollment;Ensure;equity, diversity, and inclusion;ethnic minority;ethnic minority population;Evidence based practice;experience;Faculty;faculty mentor;field trip;Foundations;Goals;graduate student;Graduation Rates;Hour;improved;Individual;innovation;Institution;Intervention;Laboratories;Leadership;Louisiana;Low income;Mathematics;matriculation;Measurable;meetings;Mentors;Mission;Modeling;Oral;Outcome;Outcome Measure;outreach;Participant;Pathway interactions;Physics;Population;Positioning Attribute;posters;programs;Qualifying;racial minority;recruit;Research;research and development;Research Personnel;Research Training;Scholars Program;Science;Science, Technology, Engineering and Mathematics;Science, Technology, Engineering and Mathematics Education;Scientist;Self Efficacy;Site Visit;skills;skills training;Special Event;student mentoring;student-centered approach;Students;success;Talents;Time;Training;training opportunity;Training Programs;trend;undergraduate research;undergraduate student;Underrepresented Minority;Underrepresented Populations;Underrepresented Students;Universities;Work

PROJECT_TITLE: LSU ESTEEMED


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

ORG_CITY: DURHAM

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: NARRATIVE Neuropsychiatric illnesses pose a significant societal challenge. Discovering more effective treatments is difficult due to our limited understanding of the brain. DART (Drug Acutely Restricted by Tethering) has shown potential in addressing this issue by enabling targeted drug delivery to specific brain cells in behaving animals. The DART.2 evolution has further bolstered this potential, offering an unprecedented thousandfold cellular specificity (Shields, et. al., 2022). With the development of DART.3, we aim to make another leap forward, potentially transforming how we approach treatments for these illnesses. This technology focuses on a noninvasive, programmable approach that could revolutionize our strategies for dealing with neuropsychiatric diseases.

PI_NAMEs: TADROSS, MICHAEL R (contact)

PROGRAM_OFFICER_NAME: KIM, EUNYOUNG

PROJECT_TERMS: Acute;Address;Adoption;Agonist;Albumins;Animal Behavior;Animals;antagonist;Axon;base;Behavior;Behavioral;Binding;Blood - brain barrier anatomy;blood-brain barrier crossing;Brain;brain cell;Brain Diseases;Brain imaging;Catalogs;cell type;Cells;Clinical;CNR1 gene;Communities;Complex;Data;Dedications;design;Development;Dopamine Receptor;dopaminergic neuron;Drug Delivery Systems;drug development;drug distribution;Drug Kinetics;Drug Receptors;Drug Targeting;effective therapy;empowerment;Ensure;Evolution;flexibility;Fostering;Funding;Generations;Hallucinogens;Histology;Hydrolysis;In Vitro;in vivo;Infusion procedures;innovation;Intervention;Intravenous Bolus;Investments;Locales;Methodology;N-Methyl-D-Aspartate Receptors;Neurobiology;Neuropharmacology;neuropsychiatric disorder;neuropsychiatry;neuroregulation;Neurosciences;Nicotinic Receptors;non-invasive imaging;Operative Surgical Procedures;Opioid Receptor;Pharmaceutical Preparations;pharmacologic;Pharmacology;photoacoustic imaging;Proteins;Public Health;public health relevance;Reagent;receptor;Renal clearance function;Reproducibility;response;Scientist;Serotonin Receptor 5-HT2A;Societies;Specificity;subcellular targeting;System;targeted delivery;Techniques;Technology;Therapeutic;Time;tool;Tracer;Training;Transgenic Mice;user-friendly;Validation;Work

PROJECT_TITLE: DART.3-Revolutionizing Neuropsychiatric Treatment through   Noninvasive, Programmable Cell-Type-Specific Neuropharmacology

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-M (01)]


ORG_DEPT: PHYSIOLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: NARRATIVE - OVERALL This consortium project is based on the hypothesis that spatiotemporally-integrated neuronal small GTPase signaling at multiple organizational levels drives the formation and function of synaptic circuits that underlie cognition and behavior. We plan to map the spatiotemporal contributions of neuronal GTPase upstream regulators to cortical development, function, and behavior through a highly integrated and collaborative center framework.

PI_NAMEs: PENZES, PETER  (contact)

PROGRAM_OFFICER_NAME: DRISCOLL, JAMIE DANIELLE

PROJECT_TERMS: Adaptive Behaviors;autism spectrum disorder;Behavior;Behavior Control;Behavioral;behavioral impairment;Biological;Brain;Catalysis;cell behavior;cell growth;cell motility;Cell Physiology;cell type;Cells;Cellular biology;Cognition;Cognitive;Complex;Decision Making;Development;differential expression;DNA Sequence Alteration;Elements;experience;Future;Gene Expression;Gene Expression Profile;gene function;Genes;Genetic;Goals;Grant;Growth;Guanosine Triphosphate Phosphohydrolases;Human;human disease;Impaired cognition;In Vitro;in vivo;in vivo Model;Individual;Institution;Intellectual functioning disability;Knowledge;Link;loss of function;maladaptive behavior;Maps;Mental disorders;Mental Health;Molecular;Molecular Target;Monomeric GTP-Binding Proteins;Morphogenesis;National Institute of Mental Health;neocortical;neural circuit;Neurobiology;neurodevelopment;Neurodevelopmental Disorder;neuronal circuitry;Neurons;novel;Pathway interactions;pharmacologic;Play;pleiotropism;Process;Proteins;Regulation;Research;Research Personnel;response;rho;Risk Factors;risk variant;RNA Splicing;Role;Schizophrenia;Sensory;Shapes;Signal Pathway;Signal Transduction;small molecule;spatiotemporal;subcellular targeting;Substrate Specificity;Synapses;synaptic function;Synaptic plasticity;synergism;SYNGAP1;System;Tertiary Protein Structure;Testing;Therapeutic;Tissues;tool;Variant

PROJECT_TITLE: Control of synaptic circuits by small GTPase pathways


PROJECT_TERMS: Awareness;Collaborations;Communication;Communities;community engagement;community partners;conflict resolution;Creativeness;data dissemination;Ensure;Foundations;Information Dissemination;Institution;International;Knowledge;Lead;Leadership;Maintenance;meetings;Monomeric GTP-Binding Proteins;neural circuit;Pathway interactions;post-doctoral training;programs;Publications;Reporting;Reproducibility;Research Personnel;Research Project Grants;Resource Sharing;Schedule;scientific hub;Series;social media;Students;success;symposium;Teleconferences;United States National Institutes of Health;web site;Writing

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Genetics;Mental Health;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PROJECT_TERMS: Amino Acids;analog;Attention;Behavioral;Binding;Biochemical;Biological;Biological Assay;Biological Process;Biology;Catalysis;Catalytic Domain;Cells;Cellular biology;Chemicals;Clinical;combinatorial;Complex;critical period;Data;Decision Making;Development;drug candidate;Family;Family member;Feedback;Gene Expression;gene function;Genes;Genetic;genetic analysis;Goals;Guanosine Triphosphate Phosphohydrolases;Homeostasis;Human;human induced pluripotent stem cells;In Vitro;in vitro activity;in vivo;Individual;induced pluripotent stem cell;Induced pluripotent stem cell derived human neuron;Induced pluripotent stem cell derived neurons;inhibitor;insight;Mental disorders;Molecular;Monomeric GTP-Binding Proteins;Morphogenesis;mouse model;Mus;Mutation;neural;neural circuit;Neurobiology;Neurons;neuroregulation;novel;paralogous gene;Pathway interactions;Patients;Pharmaceutical Chemistry;pharmacologic;Protein Analysis;protein function;Protein Isoforms;Proteins;Regulation;Reporting;rho;RNA Splicing;Role;Safety;Signal Transduction;Single Nucleotide Polymorphism;small molecule;spatiotemporal;Specificity;structural determinants;Structure;subcellular targeting;Substrate Specificity;Synapses;synaptogenesis;synergism;SYNGAP1;Tertiary Protein Structure;Testing;Time;Tissues;tool;Toxic effect;Variant

PROJECT_TITLE: Structural determinants and pharmacological modulation of synaptic GEFs and GAPs


PI_NAMEs: GEORGE, ALFRED L. (contact)

PROJECT_TERMS: Affect;Alternative Splicing;Axon;Behavior;Behavioral;Biological;Biology;Brain;cell type;Cerebrum;Coculture Techniques;Collaborations;Complement;CRISPR/Cas technology;Data;Decision Making;Defect;Dendrites;Development;excitatory neuron;Exhibits;Gene Dosage;Gene Expression;gene function;Genes;genetic variant;Goals;Growth;Guanosine Triphosphate Phosphohydrolases;Heterozygote;hindbrain;Human;in vivo;Individual;induced pluripotent stem cell;Induced pluripotent stem cell derived neurons;inhibitor;inhibitory neuron;Investigation;Knock-out;Link;loss of function mutation;Loss of Heterozygosity;member;migration;Modeling;Molecular;Monomeric GTP-Binding Proteins;Morphogenesis;Morphology;mRNA Expression;Mus;Mutant Strains Mice;Mutation;neural;neural circuit;Neurites;Neurobiology;Neurodevelopmental Disorder;neuron development;Neurons;Neurophysiology - biologic function;novel;Organoids;Pathogenicity;Pathway interactions;Pattern;pharmacologic;Phenocopy;Phenotype;Physiological;Process;Prosencephalon;protein expression;Protein Isoforms;Regulation;Research Personnel;Rodent;Signal Transduction;single-cell RNA sequencing;small molecule;spatiotemporal;Structure;success;Synapses;synaptogenesis;synergism;SYNGAP1;Tertiary Protein Structure;Testing;Time

PROJECT_TITLE: Biology of synaptic GEFs and GAPs in human neurons


NIH_SPENDING_CATS: Brain Disorders;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric

PI_NAMEs: CONTRACTOR, ANIS  (contact)

PROJECT_TERMS: Acute;Adolescent;Affect;Alternative Splicing;Architecture;ARHGEF5 gene;Behavior;Behavioral;Birth;Brain;Bromodeoxyuridine;causal variant;cell type;Chronic;Complex;critical period;Decision Making;Development;Disease;Electrophysiology (science);Gene Expression;gene function;Genes;Genetic;Genetic Predisposition to Disease;Goals;Guanosine Triphosphate Phosphohydrolases;hippocampal pyramidal neuron;in vivo;information processing;innovation;insight;Interneurons;Investigation;Knock-in Mouse;Knowledge;Label;Link;loss of function;Maps;Measurement;Measures;migration;Modeling;Molecular;Monomeric GTP-Binding Proteins;Morphogenesis;mouse model;Mus;Mutant Strains Mice;Nature;Neocortex;nerve stem cell;neural circuit;Neurobiology;neurodevelopment;Neurodevelopmental Disorder;neuron component;Neurons;novel;optogenetics;Pathogenicity;Pathway interactions;pharmacologic;Phenotype;Physiological;Play;Point Mutation;postnatal development;Production;protein function;Proteins;Radial;Regulation;Role;Sensory;Series;Shapes;Signal Transduction;Signaling Molecule;Slice;small molecule;small molecule inhibitor;Somatosensory Cortex;Spliced Genes;Symptoms;Synapses;synaptic function;Synaptic Transmission;synergism;SYNGAP1;Testing;Variant

PROJECT_TITLE: Mechanisms underlying cortical local circuit regulation by synaptic GEFs and GAPs


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences

PI_NAMEs: RUMBAUGH, GAVIN R (contact)

PROJECT_TERMS: Acute;Alternative Splicing;Behavior;Behavior assessment;Behavioral;Biochemical;Biological;Brain;Cell Physiology;Cells;Chronic;Cognition;Cognitive;Data;Decision Making;Development;excitatory neuron;Gene Expression;gene function;Genes;Genetic;Germ Lines;Goals;Guanosine Triphosphate Phosphohydrolases;Heterozygote;in vivo;inhibitory neuron;insight;Investigation;Knock-in Mouse;Link;Measures;Modeling;Molecular;Monomeric GTP-Binding Proteins;mouse model;Mus;neural;neural circuit;Neurobiology;neurodevelopment;Neuronal Plasticity;Neurons;Neurophysiology - biologic function;Neurosciences;Pathway interactions;Perceptual learning;pharmacologic;Point Mutation;Property;protein expression;Proteins;Regulation;Research;Sensory;sensory stimulus;Series;Signal Transduction;Slice;small molecule;Structure;Synapses;synergism;SYNGAP1;System;Tertiary Protein Structure;Time;TRIO gene;two photon microscopy

PROJECT_TITLE: Regulation of in vivo cortical circuit function and behavior by synaptic GEFs and GAPs


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PI_NAMEs: YOON, SEHYOUN  (contact)

PROJECT_TERMS: analog;Architecture;axion;Cerebrum;Chemicals;Coculture Techniques;Communities;Computer software;cost effective;Data;Data Analyses;Dendrites;density;Development;Devices;DNA Sequence Alteration;Dose;Electrophysiology (science);Ensure;Evaluation;Frequencies;Genes;genetic variant;high throughput analysis;high throughput screening;Human;Image;imaging system;Induced pluripotent stem cell derived human neuron;Induced pluripotent stem cell derived neurons;inhibitory neuron;innovative technologies;Instruction;Measures;Modeling;Molecular;Monomeric GTP-Binding Proteins;multi-electrode arrays;Mus;mutant;Mutation;neural circuit;Neurons;novel;Organoids;Pathway Analysis;Pathway interactions;pharmacologic;Phenotype;phenotypic data;postsynaptic;presynaptic;Quality Control;Research;response;Series;Services;Standardization;SYNGAP1;System;Testing;Time;Treatment Protocols;Variant;Work

PROJECT_TITLE: High-Content Analysis Core