NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Biotechnology;Brain Disorders;Hydrocephalus;Neurosciences;Pediatric;Rare Diseases

ORG_CITY: ORANGE

ORG_NAME: CHILDREN'S HOSPITAL OF ORANGE COUNTY

PHR: NARRATIVE Cerebrospinal fluid (CSF) shunt treatments for hydrocephalus malfunction at an unacceptably high rate, and Cellular/tissue catheter obstruction is the leading cause of this failure. Therefore, we are developing a unique bioreactor system with the incorporation of ventricular zone (VZ) cells and Choroid plexus (ChP) cultures that mimic the cytopathology, CSF flow, and intracranial pressure (ICP) linked to hydrocephalus. Thus, our approach is the only system considering ICP, CSF flow, VZ glial activation, and the adhesion and proliferation of ChP to mimic the clinical conditions associated with shunt obstruction reliably.

PI_NAMEs: CASTANEYRA RUIZ, LEANDRO  (contact)

PROGRAM_OFFICER_NAME: KUMSA, DOE WONDWOSSEN

PROJECT_TERMS: absorption;Adhesions;Air;Antibiotics;Astrocytes;biological systems;Bioreactors;Body System;Bypass;Catheters;Cell Culture Techniques;Cell Membrane Permeability;Cells;Cephalic;Cerebral Ventricles;Cerebrospinal Fluid;Cerebrospinal fluid shunts procedure;Childhood;Clinical;clinically relevant;Communicating Hydrocephalus;Cytopathology;Derivation procedure;design;Devices;Disease;Distal;Engineering;experience;experimental study;Failure;Foreign-Body Giant Cells;glial activation;Hour;Hydrocephalus;Hydrogels;immunocytochemistry;Impairment;implantation;In Vitro;in vitro Model;Inflammation;Inflammatory;Intracranial Hypertension;Intracranial Pressure;Link;Lymphocyte;Measures;migration;monitoring device;Neurosurgeon;Obstruction;Operative Surgical Procedures;Organ;Organ Culture Techniques;Pathologic;Pathology;Patients;pediatric patients;Peritoneum;Play;Positioning Attribute;Predisposition;pressure;Process;Production;Proliferating;Pump;Reaction;Research;Role;Shunt Device;Silicon;Structure of choroid plexus;Symptoms;System;Testing;Tissues;Vascularization;Ventricular

PROJECT_TITLE: New Bioreactor System to Test the Mechanisms that Underlay Catheter Malfunction Under Hydrocephalic Conditions.

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


ADMINISTERING_IC: MH

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Rehabilitation;Serious Mental Illness;Suicide

ORG_CITY: SALT LAKE CITY

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: We propose to test a neuroplasticity-based computerized cognitive remediation intervention (nCCR) (a non-invasive form of targeted brain training) against an active control intervention to improve cognitive control deficits (CCD) in patients with late life major depression (LLD) who have not responded to antidepressant treatment (SSRI/SNRI). CCD are indicative of abnormalities in the cognitive control network (CCN), a brain network whose degeneration is associated with poor clinical outcomes in LLD including, poor response to SSRI/SNRI antidepressants, severe course, relapse, disability, suicide and all-cause mortality. If successful at improving CCD and related cognitive deficits in LLD, nCCR has the potential to improve mood and cognitive impairments, and increase the number of LLD patients who are able to attain and sustain remission. nCCR is designed to be cost effective and easily disseminated and thus could reduce public health costs and have a wide-spread impact on disability and suffering in a group at high risk poor clinical outcomes

PI_NAMEs: MORIMOTO, SARAH SHIZUKO (contact);STEFFENS, DAVID C.

PROGRAM_OFFICER_NAME: EVANS, JOVIER D

PROJECT_TERMS: active control;Address;Adopted;Adoption;Affective;affective neuroscience;aging brain;Animal Model;Animals;Anterior;anti-depressive agents;Attention;behavior measurement;Behavioral;Brain;California;Cerebrum;cingulate cortex;Clinical;Clinical Trials;Clinical Trials Design;Cognitive;cognitive control;Cognitive deficits;cognitive neuroscience;Cognitive remediation;cognitive training;Communities;Computational algorithm;computerized;confirmatory trial;Corpus striatum structure;cost effective;Data;Data Analytics;depressive symptoms;design;digital medicine;digital tool;disability;Disabling;Disease;Disease remission;Doctor of Philosophy;Dorsal;dosage;Dose;Double-Blind Method;effectiveness trial;Emerging Technologies;Evidence based treatment;experience;flexibility;functional improvement;Future;geriatric depression;geriatric major depression;Health Care Costs;high risk;Impaired cognition;Impairment;improved;indexing;inhibitor;Internet;Intervention;iterative design;late life;Learning;Major Depressive Disorder;Measures;Mediating;Mediation;Medical;Mental Depression;Methodology;Methods;model design;Modeling;Moods;mortality;Multicenter Trials;multisensory;National Institute of Mental Health;Neurobiology;Neuronal Plasticity;Norepinephrine;novel;older adult;older patient;Outcome;Parietal Lobe;Participant;Patients;Performance;Pharmaceutical Preparations;Prefrontal Cortex;Procedures;Process;Public Health;Randomized;recruit;Relapse;Research Domain Criteria;Resistance;response;reuptake;Rewards;Risk;Sampling;Science;Selective Serotonin Reuptake Inhibitor;Semantics;Serotonin;Site;Structure;suicidal;suicidal risk;Suicide;symptomatic improvement;System;Technology;Testing;theories;Therapeutic;therapy resistant;Training;Translating;treatment as usual;treatment group;Utah;Verbal Learning;Work

PROJECT_TITLE: Neuroplasticity-Based Computerized Cognitive Remediation (nCCR) for Treatment Resistant Late-Life Depression


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Aging;Autoimmune Disease;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Pediatric

PHR: PROJECT NARRATIVE The proposed research is relevant to public health in its focus on improving supportive behaviors of care partners of older adults with type 1 diabetes using continuous glucose monitoring with data sharing to achieve glycemic goals. The Share plus study will be a significant step in the science of data sharing and care partner interventions to prevent age-related diabetes complications. Thus, the proposed research is relevant to part of the NIH’s mission that pertains to diabetes management in the growing population of older adults with type 1 diabetes and includes integrating a wealth of research in dyadic coping and innovative diabetes technology.

PI_NAMEs: ALLEN, NANCY ANN (contact)

PROGRAM_OFFICER_NAME: CENTER, MAUREEN MONAGHAN

PROJECT_TERMS: Address;Adopted;Adult Children;Age;age related;Behavior;benefit sharing;Caring;Cellular Phone;Chronic Disease;Clinical;Clinical Trials;clinically significant;Communication;Communication difficulty;comparison control;comparison intervention;Complications of Diabetes Mellitus;Continuous Glucose Monitor;Control Groups;control trial;coping;Dangerousness;Data;data sharing;diabetes distress;diabetes management;Diabetes Mellitus;diabetes self-management;Disease;Education;efficacy trial;Enrollment;experience;falls;Friends;Glucose;Goals;group intervention;Health;Hyperglycemia;Hypoglycemia;improved;innovation;Instruction;Insulin-Dependent Diabetes Mellitus;Intervention;Knowledge;Maintenance;Measures;Mission;mobile application;Modeling;Myocardial Infarction;National Institute of Diabetes and Digestive and Kidney Diseases;older adult;Older Population;Outcome;Persons;Phase;Pilot Projects;prevent;primary outcome;Problem Solving;Public Health;Quality of life;Randomized;Readiness;Research;response;Risk;Science;secondary outcome;Seizures;Self Care;Self Management;Signal Transduction;Spouses;Technology;telehealth;Testing;Time;tool;transmission process;trend;United States National Institutes of Health;usability;Work

PROJECT_TITLE: Share plus: Continuous Glucose Monitoring with Data Sharing in Older Adults with T1D and Their Care Partners

STUDY_SECTION: CMGC

STUDY_SECTION_NAME: Clinical Management in General Care Settings Study Section[CMGC]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Precision Medicine

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it combines computational methods for defining noncoding driver mutations in whole cancer genomes with genome editing experiments to identify their biological role in tumor development. The functional characterization of these driver events will pave the way for the development of new cancer therapies and genomic markers to select the right therapy for each patient. Hence, this project will have immediate impact on the clinical interpretation of patient sequencing data and is relevant to the NIH's mission to improve the clinical care and survival of cancer patients.

PI_NAMEs: DIETLEIN, FELIX  (contact)

PROGRAM_OFFICER_NAME: DUECK, HANNAH RUTH

PROJECT_TERMS: Accounting;Address;Advanced Malignant Neoplasm;Affect;Algorithms;Atlases;base editing;Binding;Biological;Biology;cancer gene expression;cancer genome;cancer genomics;Cancer Patient;cancer survival;cancer therapy;cancer type;career development;Cells;Chromatin Remodeling Factor;Clinical;clinical care;Clinical Markers;clinical predictors;Clustered Regularly Interspaced Short Palindromic Repeats;Code;Complex;Computer software;computerized tools;Computing Methodologies;CRISPR interference;Data;Data Set;Development;Development Plans;driver mutation;Drug Targeting;Environment;Estrogens;Event;exome;experience;experimental study;Foundations;Future;Genes;Genetics and Medicine;Genets;Genome;genome editing;genome sequencing;genomic biomarker;Genomics;Goals;Immunotherapy;improved;Individual;innovation;interdisciplinary approach;Leadership;machine learning method;Malignant Breast Neoplasm;Malignant Neoplasms;Manuals;Maps;mathematical methods;mathematical model;medical schools;Medicine;meetings;Mentors;Methods;mid-career faculty;Mission;Modeling;Mutation;new therapeutic target;novel;novel therapeutics;Oncogenic;Open Reading Frames;open source;Outcome;Pathologic Mutagenesis;Pathway interactions;Patients;precision oncology;professor;promoter;Public Health;Publications;Research;Role;Scientist;Signal Transduction;skills;Solid;Somatic Mutation;Statistical Methods;Statistical Models;Structure;symposium;System;targeted treatment;Techniques;Testing;The Cancer Genome Atlas;tool;Training;transcription factor;tumor;tumor diagnostic;tumorigenesis;United States National Institutes of Health;Untranslated RNA;whole genome

PROJECT_TITLE: A pan-cancer atlas of driver mutations in >100,000 patients based on a hypothesis-driven combined computational and experimental approach

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Transition to Independence Study Section (I)[NCI-I]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: ATLANTA

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Narrative Using genetic mouse models, we have identified POU6F2 as a genetic link between central corneal thickness and glaucoma. Our central hypothesis is that POU6F2 is a necessary part of a transcriptional network in novel RGC subtypes that are uniquely susceptible to glaucomatous insult. We will define the role of POU6F2 in the response of retinal ganglion cells to glaucoma and will also identify the molecular cascades associated with irreversible early death of ganglion cells.

PI_NAMEs: GEISERT, ELDON E (contact)

PROGRAM_OFFICER_NAME: SONG, HONGMAN

PROJECT_TERMS: Activities of Daily Living;Acute;Adult;Age;American;Anatomy;Antibodies;Binding;Biological Markers;Birth;Blindness;cell injury;Cell Survival;cell type;Cells;Cessation of life;chromatin immunoprecipitation;Classification;Collaborations;Collection;Contrast Sensitivity;Cornea;Data;Dendrites;Detection;Development;Disease;Drops;Electroretinography;Embryo;Experimental Models;experimental study;Eye;Eye Development;ganglion cell;Genes;Genetic;Genetic Transcription;genome wide association study;Glaucoma;High-Throughput Nucleotide Sequencing;Human;improved;Injections;Injury;Intervention;Knock-out;Knockout Mice;Label;Link;magnetic beads;Measures;Mediating;Metadata;Microspheres;Modeling;Molecular;Monitor;Morphology;mouse model;Mouse Strains;Mus;Nature;Nerve Crush;novel;Optic Nerve;outcome prediction;Partner in relationship;Pathway interactions;Patients;Pattern;pharmacologic;Phase;Physiologic Intraocular Pressure;Population;Predisposition;Proteins;rational design;Research Design;Resistance;response;Retina;Retinal Ganglion Cells;retinal progenitor cell;Risk;Risk Factors;Role;Structure;Technology;Testing;Thick;Thinness;transcription factor;Variant;Visual;Visual Acuity

PROJECT_TITLE: Modulators for Retinal Ganglion Cell Injury

STUDY_SECTION: BVS

STUDY_SECTION_NAME: Biology of the Visual System Study Section[BVS]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: DALLAS

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: PROJECT NARRATIVE  The major goal of this application is to implement a novel chemical genetics approach to target prioritized host chromatin regulators to assess their roles in HIV-1 proviral latency maintenance and reactivation towards efforts for a functional HIV-1 cure. We will first endogenously tag these factors in CD4+ T cell models of latency that recapitulate the biology of viral persistence in patients. We will then prioritize candidates for cross-validation in primary CD4+ T cell models of latency and aviremic patient samples.

PI_NAMEs: D'ORSO, IVAN  (contact)

PROGRAM_OFFICER_NAME: LAWRENCE, DIANE M

PROJECT_TERMS: Acute;antiretroviral therapy;Applications Grants;Attention;Basic Science;Biology;Bypass;CD4 Positive T Lymphocytes;Cell model;Cells;chemical genetics;Chromatin;Chronic;Clinic;Clinical;clinically relevant;Clonal Expansion;Clustered Regularly Interspaced Short Palindromic Repeats;Deposition;Detection;Development;Epigenetic Process;epigenetic silencing;Euchromatin;Event;extend lifespan;Family;Future;genetic approach;Genetic Transcription;Genome;Genome engineering;Goals;Growth;Heterochromatin;histone modification;Histones;HIV-1;Immune system;Immunologic Stimulation;Immunologic Surveillance;Integration Host Factors;Intervention;Knowledge;Lysine;Maintenance;Methylation;Modeling;Molecular;novel;novel strategies;Outcome;Patients;Physiological;Precision therapeutics;Proliferating;Provirus Integration;Proviruses;reactivation from latency;Refractory;Regulation;Research;RNA Interference;Role;Sampling;Shock;Source;success;targeted treatment;Therapeutic;Therapeutic Intervention;therapeutic target;Transcriptional Activation;Transferase;translational study;Validation;Viral;viral rebound;Virus Activation;Virus Latency

PROJECT_TITLE: A chemical genetics approach for studies of HIV-1 latency


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Clinical Research;Disability Research;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: SEATTLE

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative Changes in the human brain following early blindness have been widely documented, but our understanding of the mechanisms underlying this remarkable neuroplasticity is very limited. My goal is to examine the anatomical, neural, and computational constraints that allows blind individuals to meet the extraordinary challenge of learning to navigate and interact with the environment using remaining senses. This will not only facilitate the development of targeted rehabilitation programs for blind individuals, but will also help us understand the processes underlying acquisition of specialized skills (including reading and arithmetic) during development.

PI_NAMEs: PARK, WOON JU  (contact)

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: Adult;Anatomy;Area;Arithmetic;Auditory;auditory stimulus;Award;Behavioral;blind;Blindness;Brain;Brain region;Compensation;density;design;Development;Diffusion Magnetic Resonance Imaging;diffusion weighted;Environment;Equilibrium;experience;flexibility;Functional Magnetic Resonance Imaging;gamma-Aminobutyric Acid;Goals;Human;Individual;Learning;Link;Literature;Magnetic Resonance Imaging;Magnetic Resonance Spectroscopy;Mathematics;Measurement;Measures;Mediating;Mentors;Modality;Modeling;Motion;neural;Neuroanatomy;neurochemistry;Neuronal Plasticity;Neurons;Neurophysiology - biologic function;Neurotransmitters;Noise;novel;Outcome;Perception;Performance;Positioning Attribute;Process;programs;Property;Psychophysics;Reading;recruit;Recycling;Rehabilitation therapy;Research;Research Personnel;response;Rest;Role;Sensory;sensory cortex;Signal Transduction;skills;spatiotemporal;spectroscopic imaging;Techniques;Testing;Tissues;Training;Universities;Vision;visual deprivation;Visual Motion;visual processing;Visually Impaired Persons;Washington;white matter;Work

PROJECT_TITLE: Anatomical, neural, and computational constraints on sensory cross-modal plasticity following early blindness


NIH_SPENDING_CATS: Genetics

ORG_CITY: GAINESVILLE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: NARRATIVE As ligand-regulated transcription factors, nuclear receptors evolved to respond to natural small molecules, such as vitamins and lipids, translating endocrine and metabolic signals into changes in gene expression. Our data, that ligand-dependent REV-ERB activity regulates TH17 cell pathogenicity, suggests that the REV-ERBs natural endogenous ligand, heme, may function as a REV-ERB-dependent signaling molecule in TH17 cells. The proposed studies will address fundamental questions regarding ligand-dependent REV-ERBa activity, insights which will be particularly valuable in understanding TH17-mediated inflammation and may inform on future pharmaceutical approaches.

PI_NAMEs: SOLT, LAURA A (contact)

PROGRAM_OFFICER_NAME: GREENWEL, PATRICIA

PROJECT_TERMS: Affect;Aggravated Colitis;Automobile Driving;Binding;Cell Nucleus;Cells;Chronic;Colitis;Consensus;Data;Development;dietary heme;Disease;DNA;Endocrine;Enzymes;extracellular;Future;Gene Expression;Gene Expression Profile;Genes;genetic approach;genetic corepressor;genetic signature;Genetic Transcription;Genomics;Goals;gut dysbiosis;Heme;heme biosynthesis;Homeostasis;in vivo;Inflammation;Inflammatory;Inflammatory Response;insight;knock-down;Ligands;Lipids;Mediating;member;Metabolic;Molecular Biology;Molecular Immunology;mouse model;Nuclear Receptors;Pathogenesis;Pathogenicity;Pharmacologic Substance;Physiological;Process;Proteins;receptor;Regulation;Reporting;Repression;response;Response Elements;Role;Signal Pathway;Signal Transduction;Signaling Molecule;Site;small molecule;Source;T-Lymphocyte;Tissues;Transcription Coactivator;transcription factor;Transcription Repressor;Translating;Vitamins

PROJECT_TITLE: Ligand-dependent regulation of the nuclear receptor REV-ERBa in TH17 cell development and inflammation


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: MADISON

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Project Narrative More than four decades of work on how rod photoreceptors detect single photons has made the rod phototransduction the best understood of the many G-protein cascades in biological systems. The broader goal of this research is to bring a similar clarity to our understanding of the generation of cone signals in the fovea. Determining the molecular factors involved in phototransduction that make foveal cones so unique will identify potential substrates for therapy in disease conditions such as macular degeneration. By providing the first detailed insight into cone photoreceptor function in the fovea and across primate retina we will provide a benchmark to evaluate cellular function in stem cell - derived retinas which will be an important step in devising targeted interventions for millions of people with deficits in their central vision.

PI_NAMEs: SINHA, RAUNAK  (contact)

PROGRAM_OFFICER_NAME: NEUHOLD, LISA

PROJECT_TERMS: Address;Behavioral;Benchmarking;biological systems;biophysical model;Blindness;Brain;Cell Physiology;Cells;Cessation of life;Computer Models;Cone;Degenerative Disorder;density;design;Disease;effective therapy;Electrophysiology (science);Exhibits;experience;Eye Movements;Foundations;fovea centralis;Frequencies;Generations;Goals;GTP-Binding Proteins;Heterogeneity;Human;human stem cell-derived;improved;Individual;insight;interest;Intervention;Kinetics;Knowledge;Light;light intensity;Location;luminance;Macaca;Macular degeneration;Measurement;Mediating;Medical;Modeling;Molecular;Morphology;Movement;Neurons;Night Blindness;Noise;novel;Organism;Output;Perception;Performance;Peripheral;Persons;Photons;Photoreceptors;Phototransduction;Physiological;Primates;Process;Property;Prosthesis;Recording of previous events;Replacement Therapy;Research;Resolution;response;Rest;Retina;Retinal Cone;Retinal Degeneration;Retinal Diseases;retinal rods;retinotopic;Rod;Signal Transduction;stem cell therapy;stem cells;Stimulus;Testing;Time;tool;transmission process;Vision;Visual;Visual Cortex;Visual Fields;visual information;visual stimulus;Visual System;Work

PROJECT_TITLE: Photoreceptor signaling in primate retina


NIH_SPENDING_CATS: Aging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Orphan Drug;Precision Medicine;Rare Diseases;Social Determinants of Health

ORG_CITY: Los Angeles

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

ORG_STATE: CA

PHR: Project Narrative The overall objective of the USC UG1 Center is to provide the appropriate local infrastructure, governance, and support for the design, development, and conduct of innovative NCI-sponsored clinical trials within the NCTN. USC is uniquely positioned to play a leadership role because of its large and diverse patient population, its long history of active participation and scientific leadership in the national cooperative groups, especially SWOG, its scientific base and strengths in biomarker development, drug development, and identification of novel drugs targets and novel technologies essential for successful molecular diagnostics and monitoring.

PI_NAMEs: DUDDALWAR, VINAY ;EL-KHOUEIRY, ANTHONY BOUTROS;LENZ, HEINZ JOSEF  (contact)

PROGRAM_OFFICER_NAME: MOONEY, MARGARET M

PROJECT_TERMS: Advisory Committees;anatomic imaging;Area;Award;base;Biological;biomarker development;biomarker evaluation;biomedical referral center;Blood;cancer therapy;Cell Physiology;Cells;Cholangiocarcinoma;Classification;Clinical;clinical development;Clinical Research;Clinical Trials;Clinical Trials Design;Collection;Conceptions;Correlative Study;data acquisition;Dedications;design;Development;drug development;Drug Kinetics;Elderly;Ensure;ethnic minority;Evaluation;experience;Freezing;Functional Imaging;Funding;Genes;Grant;individual patient;Infrastructure;innovation;Institution;Investigation;K-Series Research Career Programs;Laboratories;Lead;Leadership;Maintenance;Malignant neoplasm of prostate;Malignant neoplasm of urinary bladder;Malignant Neoplasms;member;Mentors;metastatic colorectal;Methodology;Minority Recruitment;Modification;Molecular;Molecular Biology;molecular diagnostics;Molecular Profiling;molecular subtypes;Molecular Target;Monitor;National Clinical Trials Network;neoplastic cell;new technology;new therapeutic target;Normal tissue morphology;novel;novel anticancer drug;organizational structure;participant enrollment;Pathway interactions;patient population;Patients;Pharmaceutical Preparations;Pharmacodynamics;pharmacologic;Pharmacology Study;Play;Positioning Attribute;predicting response;predictive signature;Productivity;rare cancer;Recording of previous events;recruit;Regimen;Research Activity;Research Design;Research Infrastructure;Research Personnel;Resistance;resistance mechanism;Resources;response;Role;Safety;Sampling;Site;Southwest Oncology Group;Special Population;Standardization;Structure;targeted agent;Technology;Testing;Therapeutic Trials;Toxic effect;Training;translational study;Translations;Treatment Effectiveness;Treatment Protocols;treatment strategy;tumor;Tumor Tissue;University of Southern California Norris Cancer Center;Variant

PROJECT_TITLE: NCTN - Network Lead Academic Participating Site: USC


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision

ORG_CITY: CLEVELAND

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

ORG_STATE: OH

PHR: PROJECT NARRATIVE A major goal of the Cole Eye Institute Vision Science Training Program is to train the future leaders in vision science research and to bridge the gap between basic science ophthalmic research and clinical ophthalmology.

PI_NAMEs: ANAND-APTE, BELA  (contact)

PROGRAM_OFFICER_NAME: CLAYTON, EDWIN C

PROJECT_TERMS: Eye;Training Programs;vision science


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Aging;Bioengineering;Biomedical Imaging;Cardiovascular;Genetics;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Prevention;Racial and Ethnic Minority Health Research

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: NARRATIVE Cardiovascular disease remains the leading cause of mortality in the U.S., but its multi-factorial mechanisms and early detection are not well established. Applying new analyses of cardiovascular magnetic resonance images and integrating these measures with broad existing data including risk factors, genetics, and blood biomarkers, we will obtain deeper understanding of structure and function of the heart in older aged white and African American adults. Ultimately, accomplishment of this project will facilitate new strategies towards cardiovascular disease prevention and treatment.

PI_NAMEs: TSAO, CONNIE  (contact)

PROGRAM_OFFICER_NAME: YARDEN, RONIT I

PROJECT_TERMS: Adult;advanced disease;adverse outcome;African American;African American population;African Women;Aging;Atrial Fibrillation;Biological;Biological Markers;Biology;biracial;Blood;Cardiomyopathies;Cardiovascular Diseases;cardiovascular disorder prevention;cardiovascular disorder risk;cardiovascular imaging;cardiovascular risk factor;Cardiovascular system;caucasian American;Cause of Death;Cessation of life;Chemosensitization;Clinical;cohort;Communities;Complex;Comprehension;Computing Methodologies;Coronary Arteriosclerosis;Coronary Artery Ischemia;Data;Detection;Development;Dilated Cardiomyopathy;Dimensions;Disease;disease phenotype;Early Diagnosis;Early identification;EFRAC;Evaluation;follow-up;Functional disorder;Future;General Population;Genetic;genetic variant;genome sequencing;Genotype;Goals;Health;Heart failure;heart function;High Prevalence;human old age (65+);hypertensive heart disease;Hypertrophic Cardiomyopathy;Hypertrophy;Image;Image Analysis;improved;Individual;Inflammation;innovation;insight;Intervention;ischemic cardiomyopathy;Jackson Heart Study;Joints;Knowledge;Left Ventricular Remodeling;Left ventricular structure;Machine Learning;Magnetic Resonance;Magnetic Resonance Imaging;Mathematics;Measures;Mechanics;Methods;Morbidity - disease rate;mortality;Myocardial;Myocardial dysfunction;Myocardium;novel;Obesity;Outcome;Outcome Measure;Participant;Pathogenesis;Pathologic;Pathology;Pathway interactions;Patient Care;Pattern;Phenotype;polygenic risk score;Population;preservation;Prevalence;Prevention;Prognosis;prognostic value;quantitative imaging;Race;Radiogenomics;radiomics;Risk;Risk Factors;risk stratification;Role;secondary analysis;Serum;sex;Shapes;Single Nucleotide Polymorphism;Source;Statistical Models;Structure;Technology;Texture;therapy development;Torsion;treatment risk;trend;Ventricular Remodeling;whole genome

PROJECT_TITLE: Myocardial Radiomics and Mechanics in the Pathology and Prognosis of Cardiovascular Disease

STUDY_SECTION: CICS

STUDY_SECTION_NAME: Clinical and Integrative Cardiovascular Sciences Study Section[CICS]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Hematology;Human Genome;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Nonembryonic - Human

ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: PROJECT NARRATIVE It is now clear from large-scale sequencing of cancer genomes that mutational co-occurrence and the relative timing of mutational acquisition follow non-random patterns, but limited studies have addressed the impact of mutational order and cooperation in oncogenesis. The proposed project harnesses a unique iPSC-based model of de novo oncogenesis developed in my laboratory to address fundamental principles underlying the effects of mutational order on leukemogenesis and oncogenesis in general.

PI_NAMEs: PAPAPETROU, EIRINI  (contact)

PROGRAM_OFFICER_NAME: KLAUZINSKA, MALGORZATA

PROJECT_TERMS: Acute Myelocytic Leukemia;Address;Affect;Alleles;Biological;Biological Assay;cancer genome;Cells;Chromatin;Clinical;Clonal Evolution;Clustered Regularly Interspaced Short Palindromic Repeats;Data;driver mutation;Epigenetic Process;Event;Evolution;Exclusion;Gene Expression;Genes;Genetic;genetic analysis;Genome;Goals;Hematopoietic stem cells;Human;human induced pluripotent stem cells;In Vitro;in vivo;induced pluripotent stem cell;Laboratories;Large-Scale Sequencing;Lesion;leukemia;leukemogenesis;Malignant Neoplasms;Mediating;Modeling;Molecular;multiple omics;mutant;Mutation;Myelogenous;Nature;Normal Cell;Outcome;Pattern;Population;Population Genetics;Process;programs;Regulator Genes;Reporting;Role;Sampling;Shapes;Signal Transduction;single cell ATAC-seq;single-cell RNA sequencing;Solid Neoplasm;Somatic Mutation;SRSF2 gene;Testing;transcriptome;tumorigenesis;Work

PROJECT_TITLE: Impact of mutational order on molecular mechanisms of oncogenesis

STUDY_SECTION: MONC

STUDY_SECTION_NAME: Molecular Oncogenesis Study Section[MONC]


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

NIH_SPENDING_CATS: Asthma;Clinical Research;Hematology;Infectious Diseases;Lung;Neonatal Respiratory Distress;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn

ORG_CITY: ROCHESTER

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: PROJECT NARRATIVE The incidence of premature birth (delivery more than three weeks early) is increasing worldwide and many infants born extremely preterm (less than 28 weeks' gestation) suffer long-term lung disease resulting from injury due to oxygen therapy and mechanical ventilation. These former preterm infants experience lifelong breathing problems, including wheezing and increased respiratory infection severity which puts a high burden on the health care system because of the need for continued care and rehospitalization. This project will contribute to our understanding of reasons why preterm infants and their oxygen exposures at birth leave them vulnerable to worse respiratory infections and wheezing later in life, in attempts to alleviate this burden.

PI_NAMEs: DYLAG, ANDREW MICHAEL (contact)

PROGRAM_OFFICER_NAME: REYES, MADELYN

PROJECT_TERMS: Address;Adult;Affect;Age;Airway Disease;airway hyperresponsiveness;Antibodies;Autopsy;Award;Bioinformatics;Biological Assay;Birth;Blood Platelets;Bone Marrow;Breathing;Bronchopulmonary Dysplasia;career;career development;Caring;Cell Lineage;Cells;Childhood;Clinical;cytokine;design;Development;Development Plans;Disease;Dose;early childhood;Effector Cell;Environment;experience;experimental study;Exposure to;extreme prematurity;Fibrosis;Flow Cytometry;Functional disorder;Future;Gene Deletion;Gestational Age;Glycoproteins;Goals;Healthcare Systems;hospital readmission;Human;human disease;human tissue;Hyperoxia;Immune;Immunohistochemistry;Immunophenotyping;immunoregulation;improved;In Vitro;in vivo;in vivo Model;Incidence;Infant;Infection;Inflammatory;Influenza A virus;Influenza A Virus, H3N2 Subtype;influenza infection;Injury;interest;Investigation;K-Series Research Career Programs;Knowledge;Label;Laboratories;Lead;Life;Lung;lung development;Lung Diseases;lung repair;Mechanical ventilation;Mediator;Medical center;Megakaryocytes;Mentors;Modeling;Morbidity - disease rate;Morphology;mouse model;Mus;Myelogenous;Myeloid Cells;Myofibroblast;Neonatal;Neonatal Hyperoxic Injury;Neonatology;novel;Oxygen;Oxygen Therapy Care;pathogen;Pediatrics;Phenotype;platelet function;Population;Pregnancy;Premature Birth;Premature Infant;Production;professor;profibrotic cytokine;Profibrotic signal;recruit;Research;Respiratory Tract Infections;response;Role;Scientist;Severities;skills;targeted treatment;Technical Expertise;Testing;TGFB1 gene;THBS1 gene;Thrombospondin 1;Tissue Banks;Tissue Sample;Training;transcriptome;transcriptome sequencing;transcriptomics;Transgenic Mice;Transgenic Organisms;translational research program;Universities;Uterus;Viral Respiratory Tract Infection;Virus Diseases;Wheezing

PROJECT_TITLE: The Role of Lung Megakaryocytes in Airway Disease after Neonatal Hyperoxia

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(JA)]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Methamphetamine;Patient Safety;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: Oakland

ORG_NAME: KAISER FOUNDATION RESEARCH INSTITUTE

PHR: PUBLIC HEALTH RELEVANCE The vision of the Health Systems Node of the National Institute on Drug Abuse’s Clinical Trials Network is to transform treatment for substance use disorder through integration of care into real-word medical settings. Through its network of 16 learning health systems from across the United States, the Health Systems Node will conduct research that increases identification of patients who need care and identifies multiple effective treatment options. As part of the Clinical Trials Network, the Health Systems Node will continue to build the infrastructure required for high impact research to address the nation’s urgent need to address substance use disorder along the spectrum of care.

PI_NAMEs: BRADLEY, KATHARINE ANTHONY;CAMPBELL, CYNTHIA I (contact)

PROGRAM_OFFICER_NAME: BERTZ, JEREMIAH WILLIAM

PROJECT_TERMS: addiction;Address;Adolescent;Adult;Attention;Cannabis;Caring;Cellular Phone;Cessation of life;Chronic;clinical practice;Clinical Trials Network;Collaborations;collaborative care;comparative effectiveness study;Data;Dedications;disability;Drug Screening;effective therapy;Electronic Health Record;Evidence based treatment;experience;Faculty;Faculty Recruitment;Family;Friends;Health;Health Care Visit;Health system;Healthcare;Healthcare Systems;HIV;illicit drug use;implementation research;implementation trial;improved;Individual;Information Systems;Infrastructure;innovation;integrated care;Leadership;Learning;Legal;Life;Mainstreaming;marijuana use;marijuana use disorder;Measurement;Measures;Medical;medical specialties;Medicine;methamphetamine use;Methamphetamine use disorder;Methods;Monitor;Morbidity - disease rate;mortality;multidisciplinary;National Institute of Drug Abuse;neglect;Newly Diagnosed;novel;novel strategies;Nurses;opioid epidemic;opioid overdose;Outcome;Outcome Measure;patient engagement;Patient Outcomes Assessments;patient retention;Patient-Focused Outcomes;Patients;Persons;point of care;Population Heterogeneity;Population Research;Population Study;Positioning Attribute;pragmatic implementation;pragmatic trial;Pregnant Women;Primary Care;Provider;Psychiatry;Public Health;Public Health Practice;public health relevance;Quality of Care;Randomized, Controlled Trials;Research;Research Design;Research Institute;Research Personnel;Rural Community;screening;Severities;shared decision making;Site;social stigma;Sorting;Stigmatization;substance use;Substance Use Disorder;substance use treatment;success;Symptoms;synthetic opioid;System;Telephone;Testing;Translating;treatment and outcome;treatment response;Underrepresented Minority;United States;United States National Institutes of Health;Vision;Work;young adult;Youth

PROJECT_TITLE: Health Systems Node of the NIDA Clinical Trials Network


ADMINISTERING_IC: NS

ED_INST_TYPE: HOSPITALS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Genetics;Human Genome;Neurosciences;Radiation Oncology;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: HOUSTON

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: Public Health Relevance Statement: Glioblastoma (GBM) is the most prevalent and malignant primary brain tumor in adults, with a median patient survival of about 15 months after standard treatment. The proposed research will define the role of a novel long non-coding RNA (lncRNA) and a lncRNA/RNA-binding protein complex in promoting the cell-cycle progression and in regulating radiosensitivity of GBM cells/glioma stem cells (GSCs), and will reveal a new mechanism of its function. The proposed studies will provide new insight into how lncRNAs contribute to the molecular pathogenesis of GBM and may help develop effective therapeutic strategies to treat this devastating disease.

PI_NAMEs: CHEN, YIWEN  (contact)

PROGRAM_OFFICER_NAME: FOUNTAIN, JANE W

PROJECT_TERMS: Adult;Binding;Biological Assay;Biology;Brain;brain tissue;CCND1 gene;CCNE2 gene;Cell Cycle;Cell Cycle Progression;cell growth;Cell Proliferation;Cells;clinical prognosis;Clinical Sciences;Code;CRISPR interference;crosslinking and immunoprecipitation sequencing;Data;Development;Diagnostic;Diffuse;Disease;Dissection;DNA Double Strand Break;DNA Repair;Double Strand Break Repair;E2F transcription factors;effective therapy;FOXM1 gene;G1/S Transition;gain of function;Genes;Genetic Transcription;Genomics;Glioblastoma;Glioma;Gliomagenesis;Goals;homologous recombination;Human;In Vitro;in vivo;Infiltration;insight;Invaded;Ionizing radiation;loss of function;Maintenance;Malignant - descriptor;Mass Spectrum Analysis;Mediating;Messenger RNA;Molecular;multiple omics;Neuroglia;novel;novel therapeutic intervention;Nucleotides;Pathogenesis;Patients;Post-Transcriptional Regulation;posttranscriptional;Primary Brain Neoplasms;Prognostic Marker;Proliferating;protein complex;Proteins;Proteomics;public health relevance;Radiation therapy;Radiation Tolerance;Regulation;Research;Resistance;ribosome profiling;RNA;RNA-Binding Proteins;Role;self-renewal;Spinal Cord Neoplasms;standard care;stem cell proliferation;stem cell self renewal;stem cells;Stress;Therapeutic;therapeutically effective;transcription factor;transcriptome sequencing;Tumor Promotion;Untranslated RNA;Xenograft Model

PROJECT_TITLE: Systematic dissection of function and mechanism of long non-coding RNAs in glioblastoma

STUDY_SECTION: CAMP

STUDY_SECTION_NAME: Cancer Molecular Pathobiology Study Section[CAMP]


ADMINISTERING_IC: AG

ED_INST_TYPE: GRADUATE SCHOOLS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_DEPT: GENETICS

ORG_NAME: ROCKEFELLER UNIVERSITY

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it focuses on developing state-of-the-art single-cell genomic approaches that enable a comprehensive view of cellular temporal-spatial dynamics in neurogenesis and apply them to investigate the molecular mechanism underlying neurogenesis dysregulation in aging and Alzheimer’s disease. Once such strategies have been developed, there is a potential for a significant advance in designing therapeutic targets to trigger neurogenesis and restore cell population homeostasis in aging and neurodegenerative diseases. Thus, the proposed research is relevant to the part of NIH’s mission that pertains to reducing illness and disability.

PI_NAMEs: CAO, JUNYUE  (contact)

PROGRAM_OFFICER_NAME: DIBATTISTA, AMANDA

PROJECT_TERMS: Abnormal Cell;Adult;adult neurogenesis;Affect;Aging;aging brain;aging process;Alzheimer's Disease;Alzheimer's disease patient;Autopsy;Brain;brain cell;Brain Diseases;Brain region;Cell Communication;Cell Differentiation process;Cell Proliferation;Cells;cost;Data Set;design;Detection;Development;disability;Disease;effective therapy;Event;Foundations;Frequencies;Functional disorder;Gene Expression;Gene Expression Regulation;Generations;Genetic;Genomic approach;Goals;Heterogeneity;Hippocampus;Homeostasis;Human;Impairment;in vivo;Libraries;life span;Maps;Messenger RNA;Methodology;Methods;Mission;Molecular;molecular dynamics;Molecular Profiling;Mus;nerve stem cell;Nervous System Disorder;neural;Neurodegenerative Disorders;neurogenesis;Neurons;neuropsychiatric disorder;neurotransmission;new therapeutic target;newborn neuron;novel;novel strategies;old mice;Outcome;Pathologic;Play;Population;Preparation;Prevention strategy;Process;programs;Protein Isoforms;Public Health;rational design;Regulation;Research;Resolution;Role;Sampling;single cell genomics;stem;stem cell niche;System;Techniques;therapeutic target;Tissues;transcriptome;transcriptomic profiling;transcriptomics;United States National Institutes of Health;Work

PROJECT_TITLE: Development of novel genomic approaches for profiling cellular temporal-spatial dynamics of neurogenesis in Aging and Alzheimer's disease


ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Epithelial cells line the airways and are important for maintaining lung health. Airway epithelial cell dysfunction is a key feature of asthma and other common airway diseases. This project will study how genes are regulated in airway epithelial cells and is designed to provide a scientific basis for designing new approaches to prevent, cure, or treat airway diseases.

PI_NAMEs: ERLE, DAVID J (contact)

PROGRAM_OFFICER_NAME: LU, JINING

PROJECT_TERMS: Address;Airway Disease;airway epithelium;airway obstruction;Asthma;Biological Assay;Biology;career;Cell Culture Techniques;Cell Line;Cell Physiology;cell type;Cells;ChIP-seq;Clinical;Clinical Research;Clustered Regularly Interspaced Short Palindromic Repeats;Creativeness;cytokine;design;Development;Disease;disorder risk;Environment;Epithelial Cells;Epithelium;experimental study;Functional disorder;Gene Expression;Gene Expression Regulation;Genes;Genetic;genetic variant;Goals;Human;insight;Lung Diseases;lung health;Mediating;Molecular;mouse model;novel strategies;Nucleic Acid Regulatory Sequences;Pathogenicity;Play;Population;Positioning Attribute;prevent;Regulator Genes;Reporter;Research Personnel;Resources;response;Role;single-cell RNA sequencing;System;Technology;Therapeutic;Transgenic Mice;Work

PROJECT_TITLE: Airway epithelial cell gene regulation: new mechanisms and therapeutic strategies


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Immunotherapy;Pancreatic Cancer;Rare Diseases

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE Immunotherapy has revolutionized the way we treat a number of malignancies, but to date its impact in pancreatic cancer has been marginal. We know, for example, that conventional immune checkpoint inhibitors approved for use in melanoma, lung cancer, and other solid tumors show little or no benefit for the vast majority of pancreatic cancer patients, and that additional “priming” of the immune system will be absolutely necessary to overcome the intrinsic resistance of pancreatic tumors to immunotherapy. To achieve this goal, we will study in preclinical models of pancreatic cancer and in a clinical trial a new immunotherapeutic strategy that combines drugs across several therapeutic classes shown by our data to be highly interdependent.

PI_NAMEs: DONAHUE, TIMOTHY R;RADU, CAIUS GABRIEL (contact);WAINBERG, ZEV A

PROGRAM_OFFICER_NAME: OLKHANUD, PUREVDORJ BALJINNYAM

PROJECT_TERMS: Adenosine;Anabolism;Animal Model;anti-CTLA4;anti-PD-1;Antigen Presentation Pathway;Bioinformatics;Biometry;Biopsy;Cancer Biology;Catabolism;Cell Culture Techniques;Cell model;cell type;chemokine;Clinical;clinical development;Clinical Trials;Colorectal Cancer;Combined Modality Therapy;Consumption;CTLA4 gene;CXCL1 gene;Data;Drug Combinations;Evaluation;Event;extracellular;first-in-human;Foundations;Future;Genetic;Glucose;Glutamine;Goals;human model;IL8 gene;Immune;immune cell infiltrate;immune checkpoint;immune checkpoint blockade;Immune checkpoint inhibitor;Immune system;Immunocompetent;Immunology;immunoregulation;Immunosuppression;Immunotherapeutic agent;Immunotherapy;improved;Inflammatory;inhibitor;ipilimumab;KRAS2 gene;KRASG12D;Liver;Malignant neoplasm of lung;Malignant neoplasm of pancreas;Malignant Neoplasms;MAP Kinase Gene;Mass Spectrum Analysis;Measurement;Measures;Mediating;Melanoma;Metabolic;Metabolism;metabolomics;Modeling;mouse model;mutant;Mutation;new combination therapies;Nivolumab;Nucleosides;nucleotide metabolism;Nucleotides;Nutrient;objective response rate;Oncogenes;Oncogenic;Organoids;pancreatic cancer cells;pancreatic cancer model;pancreatic cancer patients;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;pancreatic ductal adenocarcinoma model;pancreatic neoplasm;Pathology;Pathway interactions;Patients;Phase Ia/Ib Clinical Trial;Positioning Attribute;Pre-Clinical Model;Preclinical Testing;primary endpoint;Production;programmed cell death protein 1;programs;Progression-Free Survivals;Property;Proteomics;rational design;receptor;Receptor Inhibition;Receptor Signaling;Research Personnel;Resistance;response;response biomarker;Safety;secondary endpoint;Signal Transduction;Solid Neoplasm;Stable Disease;stable isotope;synergism;targeted treatment;Technology;Testing;Therapeutic;therapy outcome;transcriptomics;translational study;trial design;tumor;Tumor Burden;Tumor Immunity;tumor microenvironment;Tumor Promotion;tumor-immune system interactions;uptake

PROJECT_TITLE: Targeting KRAS and adenosine mediated immunosuppression in pancreatic cancer

STUDY_SECTION: DT

STUDY_SECTION_NAME: Developmental Therapeutics Study Section[DT]


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Hematology;Orphan Drug;Radiation Oncology;Rare Diseases

PHR: PROJECT NARRATIVE The University of Rochester and Wilmot Cancer Institute has a history of conducting clinical trial research through the NCI’s National Clinical Trials Network. We have maintained our commitment to clinical trials and further increased accrual rates leading to recognition as a High Performing Site by the NCI. This award will support our research activities, develop impactful clinical trials, mentor the new researchers, and provide cutting edge treatment options for patients.

PI_NAMEs: BARR, PAUL M (contact)

PROJECT_TERMS: Achievement;Adult;Award;base;Cancer Biology;cancer clinical trial;Clinical;Clinical Trials;Collaborations;Committee Membership;community based practice;community partners;Complex;Conduct Clinical Trials;Correlative Study;Country;Data;data management;Dedications;Development;Discipline of obstetrics;Disease;Eastern Cooperative Oncology Group;Elderly;Enrollment;Ensure;Faculty;Funding;gastrointestinal;Genitourinary system;Goals;Gynecologic Oncology;Gynecology;Health;Hematology;improved outcome;Institution;Investments;Laboratory Research;Lead;Leadership;leukemia;Lymphoma;Malignant - descriptor;Malignant Neoplasms;Marketing;Medical Oncology;Medicine;member;Mentors;Minority;Mission;multidisciplinary;Multiple Myeloma;National Clinical Trials Network;novel therapeutic intervention;Oncology;oncology program;Operative Surgical Procedures;participant enrollment;Patients;performance site;Phase;Population;Positioning Attribute;Prevention;programs;Protocols documentation;Publications;Radiation Oncology;rare cancer;Rare Diseases;Recording of previous events;Research;Research Activity;Research Institute;Research Personnel;Role;Site;Southwest Oncology Group;Structure;success;Surgical Oncology;therapy outcome;Time;Tissue Banks;Underrepresented Populations;Universities;Urology;Work;working group;young adult

PROJECT_TITLE: Rochester Network Lead Academic Participating Site


PHR: Project Narrative Obesity related to overnutrition has become a global epidemic that increasingly strains our health care system and has few effective non-surgical therapies. Here, we seek to better understand how high fat diet causes hypothalamic inflammation, one of the earliest pathological responses to overnutrition observed. We focus on the critical role tanycytes, a unique cell type that faces the blood stream on one side and the brain on the other, play in initiating the pathologic response to overnutrition.

PI_NAMEs: TSAI, LINUS TZU-YEN (contact)

PROGRAM_OFFICER_NAME: BASU, RAJATAVA

PROJECT_TERMS: Address;Adult;Anatomy;Astrocytes;ATAC-seq;Atlases;Autopsy;Behavior;Blood;Blood - brain barrier anatomy;Blood Circulation;Brain;brain parenchyma;Cell Communication;Cell Line;Cell Physiology;cell type;Cells;Ceramides;Circulation;Cleavage Under Targets and Release Using Nuclease;combat;Communication;Complex;constitutive expression;Continuous Capillary;CRISPR/Cas technology;Cues;Data;design;Desire for food;Diet;Disparate;endoplasmic reticulum stress;Endothelium;energy balance;Ependymal Cell;Epidemic;epigenomic profiling;Face;Fenestrated Capillary;Fertility;Gene Expression Profiling;Genes;Genetic Models;Genetic study;Glucose;glucose metabolism;Healthcare Systems;High Fat Diet;Homeostasis;Human;Hypothalamic structure;improved;Infiltration;Inflammation;Inflammatory;Inflammatory Response;Insulin Resistance;insulin sensitivity;Interferon Activation;Interferons;IRF3 gene;knockout gene;Lactation;Life;Location;LoxP-flanked allele;Magnetic Resonance Imaging;MAPK8 gene;median eminence;Mediating;Mediator;Metabolic dysfunction;metabolic phenotype;Methods;Microglia;Modeling;Molecular;Molecular Target;Mus;neurogenesis;Neurons;Nutritional;Obesity;obesogenic;Overnutrition;Participant;passive transport;Pathologic;Pathway Analysis;Pathway interactions;Peripheral;peripheral blood;Pharmacological Treatment;Phenotype;Physiological;Physiology;Play;Positioning Attribute;Process;programs;receptor;Regulation;Regulatory Element;response;RNA;Rodent Model;Role;Sentinel;Side;Signal Transduction;single cell sequencing;single nucleus RNA-sequencing;single-cell RNA sequencing;stem cell niche;Stream;Structure of nucleus infundibularis hypothalami;Testing;Therapeutic;Tissues;TLR4 gene;Transcriptional Activation;transcriptome sequencing;Ventricular;Weight Gain;Work

PROJECT_TITLE: The role of interferon regulatory factors in tanycytes during HFD-induced inflammation, obesity and glucose dysregulation

STUDY_SECTION: POMD

STUDY_SECTION_NAME: Pathophysiology of Obesity and Metabolic Disease Study Section[POMD]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: ANN ARBOR

ORG_DEPT: PHYSICAL MEDICINE & REHAB

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: The proposed project will address an urgent public health need to optimize the accuracy and validity in measuring cognitive decline due to AD/ADRD in the rapidly growing and aging Latino/a/x older adult population. The proposal will investigate whether available tools for the assessment of cognitive impairment due to AD/ADRD measure cognitive and functional decline equivalently in Latino/a/x compared to non-Latinx white older adults. This research will lead to more accurate estimates of the prevalence, determinants, and impact of AD/ADRD in Latino/a/x older adults.

PI_NAMEs: BRICENO, EMILY MARIE (contact)

PROGRAM_OFFICER_NAME: STOECKEL, LUKE

PROJECT_TERMS: Adult;Affect;Aging;Alzheimer disease detection;Alzheimer's disease related dementia;Assessment tool;Attenuated;brain health;career;career development;Cognition;Cognitive;cognitive ability;Cognitive aging;cognitive interview;cognitive testing;cohort;Collaborations;Communities;Data;Data Analyses;Data Collection;Data Pooling;Diagnosis;Disparity;Education;Educational Status;Educational workshop;Environment;ethnic difference;Ethnic Origin;Exhibits;follow-up;functional decline;Funding;Goals;Grant;Growth;Health;Health and Retirement Study;health data;Health Disparities Research;health disparity;health equity;Hispanic;human old age (65+);Impaired cognition;improved;Individual;informant;instrument;International;Intervention;Investigation;Knowledge;Language;Latina;Latino;Latinx;Latinx population;Leadership;Linguistics;Measurement;Measures;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Methodology;Methods;Mexican Americans;Michigan;Neuropsychology;novel;older adult;Outcome;Participant;Performance;Population;population based;Prevalence;Protocols documentation;Psychometrics;Public Health;public health priorities;Qualitative Methods;Qualitative Research;Research;research and development;Research Personnel;Resources;Respondent;Risk;Risk Factors;Sampling;Series;skills;sociocultural determinant;Spanish;Spanish/English;Stroke;symposium;Training;training opportunity;United States National Institutes of Health;Universities

PROJECT_TITLE: Measurement of cognition and functional decline in Latinx older adults for detection of Alzheimer’s Disease and Related Dementias: A mixed-methods approach

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development for Clinicians/Health Professionals Study Section [AGCD-3]


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Digestive Diseases;Genetics;Immunotherapy;Orphan Drug;Pancreatic Cancer;Precision Medicine;Rare Diseases

ORG_CITY: BALTIMORE

ORG_DEPT: SURGERY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative This research seeks to improve long-term survival for individuals diagnosed with pancreas cancer by (1) evaluating the safety and efficacy of a potentially curative surgical resection for patients with initially unresectable disease, (2) validating a novel culture technique as a tool to deepen our fundamental knowledge of the disease and (3) demonstrate the promise of applying a novel culture technique to provide personalized therapeutic recommendations, lengthen life, and increase rates of cure. This research will also serve as a foundation for career development with a goal of providing leadership in future team science initiatives.

PI_NAMEs: BURKHART, RICHARD ANDREW (contact)

PROGRAM_OFFICER_NAME: RADAEV, SERGEY

PROJECT_TERMS: advanced disease;Advisory Committees;Aftercare;Award;Basic Science;Biological Markers;Biology;Biopsy;Cancer Biology;cancer care;Cancer Center;Cancer Etiology;career development;Caring;Cell Line;Cessation of life;chemotherapy;Clinic;Clinical;Clinical Oncology;Clinical Research;Clinical Treatment;Clinical Trials;Clinical Trials Design;clinically actionable;clinically relevant;Colon Carcinoma;Combined Modality Therapy;Comprehensive Cancer Center;Culture Techniques;Curative Surgery;Cytotoxic Chemotherapy;Data;design;Development;Development Plans;Diagnosis;Disease;disease model;drug sensitivity;Eligibility Determination;Environment;Excision;experience;Exposure to;Extramural Activities;Fostering;Foundations;four-arm trial;Funding;Future;Gene Expression;Gene Expression Profile;Gene Expression Profiling;Genetic;Genotype;Glean;Goals;Guidelines;Heterogeneity;hormone therapy;Image;Immune;immunohistochemical markers;Immunotherapy;improved;In Vitro;Individual;Institution;K-Series Research Career Programs;Knowledge;Laboratories;Leadership;Life;Losartan;Malignant Breast Neoplasm;Malignant neoplasm of pancreas;Mentors;Mentorship;Methods;Microsatellite Instability;Modeling;Molecular;molecular marker;Newly Diagnosed;Nivolumab;novel;novel therapeutics;Operating Rooms;operation;Operative Surgical Procedures;Organoids;Outcome;Pancreatic Ductal Adenocarcinoma;patient derived xenograft model;patient oriented;patient screening;Patient-Focused Outcomes;Patients;personalized therapeutic;Persons;Pharmaceutical Preparations;Phase;Phase II Clinical Trials;Pre-Clinical Model;precision medicine;Precision medicine trial;Precision therapeutics;Primary Neoplasm;programs;Radiation;Radiation therapy;Randomized;Recommendation;Recording of previous events;recruit;Recurrent disease;Research;Research Personnel;Resectable;Resected;Resources;response;Role;Safety;Science;Scientist;Speed;Surgeon;Surgical Oncology;Systemic Therapy;Testing;Therapeutic;Time;tool;Training;translational cancer research;Translational Research;treatment response;treatment strategy;tumor;tumor heterogeneity;two-dimensional;United States;Universities;Unresectable;Work

PROJECT_TITLE: Personalized preclinical models in pancreas cancer: a tractable approach to precision medicine

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative Vision impairment affects over 4 million Americans over the age of 40, at a direct cost of over $140 billion dollars per year, producing a critical need to train the next generation of vision scientists to work in areas of translational vision science. Our goal is to train vision scientists who understand the need for translation of their discoveries in the laboratory to clinical treatment and rehabilitation strategies, armed with an understanding of the biology and pathophysiology of vision disorders that will facilitate development of therapies and potential cures to blinding and vision impairing diseases. As faculty with significant translational components to our work and with processes in place to aid in this training, we are well positioned to train these future translational vision scientists.

PI_NAMEs: JUNGE, HARALD ;MCLOON, LINDA K. (contact)

PROJECT_TERMS: Training Programs;vision science

PROJECT_TITLE: Training Program in Translational Vision Sciences


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Mental Health;Neurosciences;Substance Misuse

ORG_CITY: PHILADELPHIA

ORG_DEPT: PSYCHOLOGY

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

ORG_STATE: PA

PHR: PROJECT NARRATIVE Interactions between mesolimbic dopamine systems and hippocampus are tailored to support the active acquisition of salient information into long-term memory, a process that supports a variety of adaptive behaviors such as memory selectivity, generalization, and decision-making. Similarly, this circuit contributes to motivated behaviors that occur in the absence of explicit rewards which are relevant to substance abuse — such as craving and relapse. This proposal examines how mesolimbic-hippocampal interactions contribute to episodic memory in the context of active information seeking to build a framework to understand how mesolimbic signaling at multiple timescales interact to shape memory encoding and consolidation in the absence of explicit reward feedback

PI_NAMEs: MURTY, VISHNU PRADEEP (contact)

PROGRAM_OFFICER_NAME: PARIYADATH, VANI

PROJECT_TERMS: Active Learning;Adaptive Behaviors;animal data;Animal Model;Behavior;Behavior assessment;Behavioral;Behavioral Paradigm;Cognitive;Computer Models;contextual factors;Corpus striatum structure;craving;Cues;Decision Making;Development;Dopamine;drug seeking behavior;Elements;Environment;Episodic memory;Event;experience;Feedback;forgetting;Functional Magnetic Resonance Imaging;Future;Hippocampus;Human;Incubated;Individual;Individual Differences;information processing;information seeking behavior;insight;Knowledge;Learning;long term memory;Mediating;Memory;memory consolidation;memory encoding;mesolimbic system;Modeling;motivated behavior;Motivation;neuroimaging;novel;Outcome;Perception;Pharmaceutical Preparations;Phase;Pre-Clinical Model;Process;Psychiatry;Psychological reinforcement;Relapse;Research;response;Rewards;Risk;Risk Factors;Rodent;Sampling;Shapes;Signal Transduction;Substance abuse problem;substance use;Support System;Testing;tool;Uncertainty;Ventral Tegmental Area

PROJECT_TITLE: The influence of mesolimbic-hippocampal interactions on episodic memory during active information seeking

STUDY_SECTION: HCMF

STUDY_SECTION_NAME: Human Complex Mental Function Study Section[HCMF]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Aging;Arthritis;Biomedical Imaging;Chronic Pain;Clinical Research;Osteoarthritis;Pain Research

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Project Narrative: Symptomatic knee osteoarthritis is a prevalent and disabling condition that has few effective treatments that alter the natural history of the disease. Intra-articular inflammation manifesting as synovitis is an important phenotype and potential treatment target. This proposal seeks to better understand the role of synovitis in osteoarthritis pain, progression and treatment.

PI_NAMEs: MACFARLANE, LINDSEY A. (contact)

PROGRAM_OFFICER_NAME: ZHENG, XINCHENG

PROJECT_TERMS: Accounting;Address;Adrenal Cortex Hormones;Adult;Affect;Anti-Inflammatory Agents;Attenuated;Bilateral;Biological Markers;Biometry;career development;cell type;Cells;Characteristics;Clinical;cohort;Complex;Data;Degenerative polyarthritis;design;Development;disability;Disabling condition;Disease;disease natural history;Education;effective therapy;effusion;Environment;Epidemiology;Exhibits;experience;Funding;Funding Opportunities;Future;Gene Expression Profile;Goals;Hospitals;Image;Imaging Techniques;Immunology;Individual;individualized medicine;Inflammation;Inflammatory;Injections;Knee;Knee Osteoarthritis;knee pain;Lead;Magnetic Resonance Imaging;medical schools;Mentors;Methods;Modeling;Molecular;multidisciplinary;novel;Orthopedics;osteoarthritis pain;Pain;Pain management;Pain Measurement;pain relief;Patient Recruitments;Patients;Phenotype;Positioning Attribute;Process;prognostic model;Public Health Schools;radiological imaging;Radiology Specialty;recruit;Registries;repaired;Reporting;Research;Research Personnel;response;Rheumatology;Role;Sensory;Series;Severities;single-cell RNA sequencing;Statistical Models;Steroids;Subgroup;Synovial Cell;Synovial Membrane;Synovitis;Testing;Time;Tissues;transcriptome sequencing;transcriptomics;ultrasound;Woman;Work

PROJECT_TITLE: The Role of Inflammation in Knee Osteoarthritis

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Project 1 Narrative The Tabas R35 program will explore new, highly interrelated concepts related to four key areas in which critical gaps in atherosclerotic cardiovascular disease exist: inflammation resolution & efferocytosis (safe clearance of dead cells); pathophysiology of the minority of atherosclerotic lesions that are most clinically important; immunometabolism in macrophages (how macrophages process molecules to alter function); and aging- related clonal hematopoiesis (expansion of blood cells that is common in aging). The flexibility and forward- looking nature of this R35 program will allow expansion of these areas into human atheroma tissue studies, human genetics, and studies with genetically engineered human macrophages to complement the human genetic studies. Successful completion of this R35 program will address key gaps in our knowledge of how the most clinically dangerous atherosclerotic plaques develop; lead to the design of novel therapeutic strategies; and promote the training and mentoring of young scientists in this critical area of research.

PI_NAMEs: TABAS, IRA A (contact)

PROGRAM_OFFICER_NAME: HASAN, AHMED A  K

PROJECT_TERMS: Acute;age related;Aging;aging related;amino acid metabolism;Amino Acids;Anti-Inflammatory Agents;Apoptotic;Area;Arterial Fatty Streak;Atherosclerosis;Blood Cells;Cardiometabolic Disease;Cardiovascular Diseases;Cardiovascular system;Cells;Clinical;clinically relevant;Collaborations;Complement;CRISPR/Cas technology;Dangerousness;Data;design;Etiology;flexibility;Functional disorder;Genes;Genetic Engineering;Genetic study;Grant;Hematopoiesis;Human;Human Engineering;Human Genetics;Impairment;induced pluripotent stem cell;Inflammation;Interruption;Journals;Knowledge;Lead;Link;Macrophage;Mediating;Mediator;Mentors;Metabolic;Metabolism;Minority;monocyte;Mus;Nature;Necrosis;novel therapeutic intervention;Pathway interactions;Pre-Clinical Model;precision medicine;Process;programs;Publishing;Research;Research Personnel;Resolution;Risk Factors;Safety;Scientist;Testing;Therapeutic;Thinness;Tissues;Training;translational research program;United States National Institutes of Health;Vision;Work

PROJECT_TITLE: A Mechanistic and Translational Research Program Linking Impaired Resolution, Defective Efferocytosis, and Clonal Hematopoiesis to the Formation of Clinically Dangerous Atherosclerotic Plaques


NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Genetics;Human Genome;Macular Degeneration;Neurodegenerative;Neurosciences;Prevention;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

PHR: PROJECT NARRATIVE The proposed project is relevant to public health as it will elucidate key genetic mechanisms that contribute to the development of age-related macular degeneration (AMD), the most common cause of vision loss in the United States among people over the age of 55 years. The research will achieve this objective by optimizing and validating experimental systems for studying genetic risk factors of AMD that are currently poorly understood. The novel insights gained by completion of this study will immediately facilitate the discovery and interpretation of new disease-contributing mutations and enable the development of therapies to treat visual disorders that affect people of all ages.

PI_NAMEs: CHERRY, TIMOTHY JOEL (contact)

PROGRAM_OFFICER_NAME: SHEN, GRACE L

PROJECT_TERMS: 10q26;Address;Affect;Age;age effect;Age related macular degeneration;Automobile Driving;barrier to testing;Biological Models;Biology;Blindness;Cell Culture System;Cell Physiology;cell type;Cells;Data;Development;Disease;DNA Sequence;Elements;Enhancers;Evolution;Experimental Models;experimental study;Gene Expression;Genes;Genetic;genetic analysis;Genetic Risk;genetic risk factor;Genetic study;Genetic Variation;genome wide association study;Goals;Histology;Human;human induced pluripotent stem cells;improved;In Vitro;in vitro Model;in vitro testing;in vivo;induced pluripotent stem cell;Inherited;insight;Knock-out;Knockout Mice;Knowledge;Late-Onset Disorder;macula;Maps;Methods;MicroRNAs;model organism;Modeling;mouse genome;mouse model;multiple omics;Mus;Mutation;myocyte-specific enhancer-binding-factor 2C;novel;Organoids;Other Genetics;Outcome;Persons;Public Health;Regulation;Regulatory Element;Research;Retina;Retinal Diseases;Risk;Risk Factors;risk variant;Role;Shapes;single-cell RNA sequencing;Structure;Structure of retinal pigment epithelium;Study models;System;Testing;therapy development;tissue culture;Tissues;Transgenic Mice;United States;Untranslated RNA;Vision;Vision Disorders;Visual;Work

PROJECT_TITLE: Optimizing Models of Non-Coding Genetic Risk in Age-Related Macular Degeneration

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Congenital Heart Disease;Gene Therapy;Genetics;Heart Disease;Orphan Drug;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_DEPT: PHYSIOLOGY

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: Project Narrative The proposed research project is relevant to public health as acquiring knowledge regarding genome editing of cardiac Ryanodine Receptor Type-2 is expected to lead to a better understanding of how cardiac gene therapy can treat ventricular arrhythmias and other cardiovascular conditions related to dysregulation of this critical calcium channel. Such knowledge may ultimately lead to new therapeutic approaches that focus on correcting the underlying causes of genetic cardiac disorders. Thus, this research is relevant to the NIH’s mission as it seeks to acquire knowledge that will aid in the treatment of human disease and disability.

PI_NAMEs: MOORE, OLIVER  (contact)

PROGRAM_OFFICER_NAME: MEADOWS, TAWANNA

PROJECT_TERMS: 3-Dimensional;Address;Affect;Age;Alleles;Arrhythmia;base editing;Calcium;Calcium Channel;Cardiac;Cardiac Myocytes;Cardiovascular system;Catecholaminergic Polymorphic Ventricular Tachycardia;causal variant;confocal imaging;Confocal Microscopy;CRISPR therapeutics;CRISPR/Cas technology;Data;Death Rate;deep sequencing;Defibrillators;Dependovirus;disability;Disease;disease-causing mutation;Double Effect;Echocardiography;effective therapy;Effectiveness;Electric Stimulation;Electrocardiogram;Emotional Stress;Event;Exertion;gene therapy;gene-editing approach;Genes;Genetic;genome editing;Goals;Heart;Heart Abnormalities;Heart Diseases;heart function;heart rhythm;Heterozygote;Human;human disease;Human Genome;Image;implantation;improved;in vivo;Individual;induced pluripotent stem cell;induced pluripotent stem cell derived cardiomyocytes;Inherited;Injections;insertion/deletion mutation;knock-down;Knowledge;Knowledge acquisition;Lead;Left;Lentivirus;Light;Long-Term Effects;Measures;Medical;Mendelian disorder;Messenger RNA;metabolomics;Methods;Microscopy;Mission;Molecular Analysis;mouse model;Mus;Muscle Cells;mutant;Mutation;mutation correction;non-compliance;novel;novel strategies;novel therapeutic intervention;Operative Surgical Procedures;Organoids;Patients;Pharmacological Treatment;Physiological;Pre-Clinical Model;Predisposition;preservation;prevent;prime editing;Protein Isoforms;Proteins;Public Health;repaired;Reporter Genes;Research;Research Project Grants;Risk;Ryanodine Receptor Calcium Release Channel;RyR2;Sarcoplasmic Reticulum;side effect;Silent Mutation;Site;Specificity;Stress Tests;sudden cardiac death;Sudden Death;Sympathectomy;Syncope;System;targeted treatment;Technology;Testing;therapeutic evaluation;therapeutic genome editing;United States National Institutes of Health;Variant;vector;Ventricular;Ventricular Arrhythmia;Ventricular Tachycardia

PROJECT_TITLE: Genome Editing Treatment for Catecholaminergic Polymorphic Ventricular Tachycardia


NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Precision Medicine

ORG_CITY: CHARLESTON

ORG_DEPT: PSYCHIATRY

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: PROJECT NARRATIVE Anxiety and related disorders remain prevalent and costly, and although effective treatments exist, many who suffer with these disorders cannot complete or do not benefit from treatment. Research initiated here seeks to more effectively target, with non-invasive brain stimulation, pervasive avoidance of day-to-day activities, a key disorder feature that keeps many from fully engaging in treatment or attaining symptom remission. Since major depression, substance misuse, and various other mental health disorders also involve pervasive avoidance as a key feature, proposed research could have implications far beyond the anxiety spectrum of disorders.

PI_NAMEs: SEGE, CHRISTOPHER  (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: Address;Adjuvant;Adjuvant Therapy;Ambulatory Care;Amygdaloid structure;Anhedonia;Animals;Anxiety;anxiety spectrum disorders;anxious;approach/avoidance behavior;Area;Aversive Stimulus;avoidance behavior;Basic Science;Behavior;career;career development;Clinical;clinical practice;Clinical Research;Cognitive Therapy;Collaborations;Computer Models;Conflict (Psychology);coping;Coping Behavior;Corpus striatum structure;cost;Data;Decision Making;Development;Development Plans;Diagnostic;Disease;Disease remission;Dorsal;Dropout;Educational workshop;effective therapy;Ensure;evidence base;Fostering;Fright;Functional Magnetic Resonance Imaging;Future;Goals;Grant;hands on research;Human;Impairment;improved;improved outcome;Individual;Institution;International;Intervention;Knowledge;Laboratories;Major Depressive Disorder;Maps;Mediating;Medical;Mental Depression;Mental disorders;Mental Health Services;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Methods;Modeling;Motivation;multimodality;National Institute of Mental Health;neural circuit;neuroregulation;Neurosciences;noninvasive brain stimulation;novel;Outcome;Participant;Patients;Pattern;Physiology;pre-clinical;precision medicine;precision neuromodulation;Prefrontal Cortex;Preparation;prevent;Productivity;Psychiatry;Publications;reduce symptoms;Reflex action;repetitive transcranial magnetic stimulation;Research;Research Domain Criteria;Research Methodology;Research Personnel;response;Rewards;Science;skills;South Carolina;Stimulus;substance misuse;symposium;Symptom Burden;Symptoms;Techniques;Testing;therapy outcome;tool;Training;translational applications;Translational Research;Treatment outcome;Universities;Ventral Striatum;Work;Writing

PROJECT_TITLE: Modeling and Modulating Mechanisms of Escape, Avoidance, and Approach in the Anxiety Disorder Spectrum

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Intellectual and Developmental Disabilities (IDD);Maternal Health;Mental Health;Microbiome;Neurosciences;Pediatric;Women's Health Research

PHR: Project Narrative Sensory processing disorder (SPD) is a debilitating neurodevelopmental disorder that affects a majority of children with autism spectrum disorder and manifests as over responsivity or under responsivity to stimuli that can affect social and cognitive behaviors. SPD has genetic and environmental risk factors, and biological pathways including altered white matter integrity and reduced connectivity between thalamus and sensory cortices. The goal of this study is to examine how the maternal gut microbiota affects development of microglia and neural circuits implicated in somatosensory behaviors, and identify mechanisms and novel therapeutic targets to better treat SPD.

PI_NAMEs: VUONG, HELEN  (contact)

PROGRAM_OFFICER_NAME: BARDHAN, SUJATA

PROJECT_TERMS: Adult Children;Affect;Animals;Antibiotics;autism spectrum disorder;autistic children;awake;Axon;Back;Behavior;Behavioral;Biological;Biology;Brain;Calcium;career;Central Nervous System;Child;Coculture Techniques;Cognitive;Communication;CSF1R gene;Development;Diet;Embryo;Environment;Environmental Risk Factor;Etiology;Experimental Designs;experimental study;Feedback;fetal;Fetal Reduction;Foundations;Fragile X Syndrome;Functional disorder;Gene Expression;Genetic;genetic risk factor;germ free condition;Germ-Free;glial activation;glial cell development;Goals;Grant;Growth;gut microbes;gut microbiome;gut microbiota;Hypersensitivity;Image;immune activation;improved;in utero;in vivo;in vivo imaging;Infection;inhibitor;insight;Intellectual functioning disability;K-Series Research Career Programs;Laboratory Research;late life;Lead;maternal microbiome;maternal microbiota;maternal stress;Mediating;meetings;Mentors;Methodology;Microbe;microbiome;microbiome alteration;microbiota;Microglia;migration;Molecular;Molecular Target;Morphology;Mus;Muscle fasciculation;myelination;neocortical;nerve supply;neural circuit;neurodevelopment;Neurodevelopmental Disorder;Neuroimmune;Neurons;neurophysiology;neuropsychiatric disorder;neuroregulation;new therapeutic target;novel;offspring;Pathway interactions;Patients;Phagocytes;Pharmaceutical Preparations;Phase;Phenotype;Poly I-C;postnatal;Pregnancy;prenatal;Prosencephalon;Research;response;Ribosomal DNA;Risk Factors;RNA analysis;Role;Schizophrenia;Sensory;sensory cortex;sensory processing disorder;sensory stimulus;Shapes;Signal Transduction;single-cell RNA sequencing;skills;social;somatosensory;Somatosensory Cortex;Sorting;Stimulus;Stress;symposium;Tactile;targeted treatment;Techniques;Testing;Thalamic structure;Therapeutic Intervention;Training;transcriptome;Transplantation;white matter;Work;Writing

PROJECT_TITLE: Investigating role of maternal gut microbiome in microglia-neuron dynamics and development of somatosensory circuits

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Precision Medicine;Prevention;Skin Cancer

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Melanoma:Metabolic Biomarkers of Response to Targeted Therapy Project Narrative Melanoma is currently treated with an inhibitor of a signaling protein that sends signals for the tumor cells to proliferate. While this method is initially effective in most patients, all patients eventually become resistant to this drug and have to be treated with other agents. The goal of this project is to develop an imaging method that detects the onset of resistance to this drug and indicates when treatment should be switched to an alternate drug. The study will also investigate if including a glutaminase inhibitor in the initial treatment regimen can increase or prolong effective therapy.

PI_NAMEs: BLAIR, IAN ALEXANDER;NATH, KAVINDRA  (contact)

PROGRAM_OFFICER_NAME: WANG, YISONG

PROJECT_TERMS: aerobic glycolysis;Alanine;analog;Biochemical;Biochemical Pathway;Biochemical Reaction;Biochemistry;Biological Markers;Biological Models;biomarker identification;BRAF gene;Cell Culture Techniques;Cells;Chemicals;Citric Acid Cycle;Clinic;Clinical;Clinical Trials;Data;Dependence;Detection;detection method;Drug resistance;early detection biomarkers;Early Diagnosis;effective therapy;Effectiveness;Elements;experience;feasibility testing;Genetically Engineered Mouse;Glucose;Glutamates;Glutaminase;Glutamine;Goals;Human;human model;Image;imaging modality;Immune checkpoint inhibitor;Immunocompetent;immunogenic;immunosuppressed;improved;in vivo;inhibitor;inhibitor therapy;Institution;instrument;kinase inhibitor;Knowledge;liquid chromatography mass spectrometry;magnetic field;Magnetic Resonance Imaging;MAP Kinase Gene;MAP3K1 gene;MAPK Signaling Pathway Pathway;Medical;MEKs;MEL Gene;Melanoma;Melanoma Cell;Melanoma patient;Metabolic;Metabolic Pathway;metabolic phenotype;Metabolism;metabolomics;Metastatic Melanoma;Metformin;Methods;Modeling;Monitor;mouse model;Mus;mutant;Mutate;Mutation;neoplastic cell;non-invasive imaging;Oxygen;Pathway Analysis;Pathway interactions;patient response;Patients;Pharmaceutical Preparations;Phenformin;Phosphotransferases;Physiologic pulse;precision medicine;Proliferating;Proto-Oncogene Proteins B-raf;Recurrence;research clinical testing;Resistance;response;response biomarker;Signal Transduction;Signaling Protein;System;targeted treatment;Techniques;Tissue Survival;Toxic effect;translation to humans;Translations;Treatment Protocols;treatment response;tumor;tumor growth;tumor metabolism;tumor microenvironment;Tumor Volume;Variant;Work

PROJECT_TITLE: Melanoma: Metabolic Biomarkers of Response to Targeted Therapy

STUDY_SECTION: IPCA

STUDY_SECTION_NAME: Imaging Probes and Contrast Agents Study Section[IPCA]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Congenital Structural Anomalies;Gene Therapy;Genetics;Lung;Nanotechnology;Neonatal Respiratory Distress;Orphan Drug;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pulmonary Hypertension;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

ORG_CITY: TUCSON

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: PROJECT NARRATIVE. We will use unique mouse models of Alveolar Capillary Dysplasia with Misalignment of Pulmonary Veins (ACDMPV) to determine whether neonatal lung angiogenesis, pulmonary arterial hypertension, pathologic lung remodeling and overall survival of ACDMPV mice can be improved via nanoparticle-based gene delivery of FOXF1 or its target, STAT3, into the pulmonary circulation, or via cell therapy with specialized pulmonary endothelial progenitor cells.

PI_NAMEs: KALIN, TANYA ;KALINICHENKO, VLADIMIR  (contact)

PROGRAM_OFFICER_NAME: NATARAJAN, ARUNA R

PROJECT_TERMS: ACVRL1 gene;Alleles;Alveolar;Alveolar capillary dysplasia with misalignment of pulmonary veins;angiogenesis;Applications Grants;Birth;Blood capillaries;Blood Circulation;Blood Vessels;bone morphogenetic protein 9;Bronchopulmonary Dysplasia;c-myc Genes;Cell Lineage;Cell Proliferation;Cell Therapy;Cell Transplantation;Cells;clinically relevant;Complementary DNA;Congenital alveolar dysplasia;Congenital Disorders;Cyanosis;Data;density;Development;Diaphragmatic Hernia;differentiation in vitro;Diffuse;directed differentiation;Disease;Donor person;effective therapy;Embryo;embryonic stem cell;Endothelial Cells;endothelial stem cell;Endothelium;Engraftment;Exhibits;expression vector;fibrotic lung;FOXF1 gene;Gene Delivery;gene delivery system;Genes;Genetic Transcription;genomic locus;Hemorrhage;Heterogeneity;Heterozygote;Human;human embryonic stem cell;improved;In Vitro;in vivo;Infant;Inherited;innovation;Laboratories;Life;Link;LoxP-flanked allele;Lung;lung development;Lung Transplantation;Modeling;mortality;mouse model;Mus;Mutation;nanoparticle;nanoparticle delivery;Neonatal;Neonatal lung;neonate;Newborn Infant;novel;novel therapeutic intervention;Pathologic;Pathway interactions;Patients;PECAM1 gene;postnatal;preservation;prevent;Prognosis;Proliferating;Protocols documentation;PTPRC gene;Publishing;pulmonary arterial hypertension;Pulmonary Circulation;pulmonary hypoplasia;Pulmonary veins;Resistance;respiratory;Respiratory Failure;Respiratory Insufficiency;Respiratory physiology;self-renewal;Signal Pathway;Signal Transduction;single-cell RNA sequencing;STAT3 gene;Stem cell transplant;TEK gene;Testing;Therapeutic;transcription factor;Transgenic Mice;Vascular Endothelial Growth Factors

PROJECT_TITLE: Development of novel therapeutic approaches for treatment of Alveolar Capillary Dysplasia

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CVRS-G(03)]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Conditions Affecting the Embryonic and Fetal Periods;Fetal Alcohol Spectrum Disorders (FASD);Intellectual and Developmental Disabilities (IDD);Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Social Determinants of Health;Substance Misuse

ORG_DEPT: OBSTETRICS & GYNECOLOGY

PHR: Public health relevance Previous research finds state-level policies targeting alcohol use during pregnancy at best have had no impact on drinking during pregnancy or related outcomes and, at worst, contribute to public health harms. Research has not explored the more severe outcomes related to these policies nor has it comprehensively examined which general population alcohol policies might reduce harms from drinking during pregnancy. Understanding effects of these policies is crucial to our ability to adopt and implement policies that will lead to reductions in harm from alcohol use during pregnancy.

PI_NAMEs: ROBERTS, SARAH C.M. (contact)

PROGRAM_OFFICER_NAME: BALACHOVA, TATIANA NIKOLAYEVNA

PROJECT_TERMS: Address;Admission activity;Adopted;adverse birth outcomes;Advocacy;Affect;Age;alcohol availability;Alcohol consumption;alcohol policy information system;Alcohols;Attention;Behavior;binge drinking;Birth;Characteristics;Child;Child Abuse and Neglect;Clinical;Data;Data Analyses;Data Set;Data Sources;Disease;drinking;drinking behavior;Economics;Ensure;Epidemiologic Methods;Epidemiology;Ethnic Origin;Fetal Alcohol Spectrum Disorder;Fetal Alcohol Syndrome;Fetus;General Population;Gynecologist;Harm Reduction;Health Professional;Hour;Individual;Infrastructure;insurance claims;Laws;Lead;Legal;Low Birth Weight Infant;Marijuana;maternal alcohol use;Maternal and Child Health;Methodological Studies;Minor;Morbidity - disease rate;National Institute on Alcohol Abuse and Alcoholism;Outcome;Pharmaceutical Preparations;Phase;phase 1 study;Policies;Population;Population Policies;Pregnancy;Pregnant Women;Premature Birth;Prenatal care;Prevention;Price;Productivity;Professional Education;Public Health;public health priorities;public health relevance;Public Policy;public policy on alcohol;Race;racial difference;Reporting;reproductive;Research;response;Socioeconomic Status;Substance Use Disorder;Surveys;Taxes;Teratogens;Time;Translating;Woman

PROJECT_TITLE: Alcohol and pregnancy: benefits and harms of state-level policies

STUDY_SECTION: CIHB

STUDY_SECTION_NAME: Community Influences on Health Behavior Study Section[CIHB]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Brain Disorders;Drug Abuse (NIDA only);Mental Health;Neurosciences;Substance Misuse

ORG_CITY: ITHACA

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CORNELL UNIVERSITY

PHR: Project Narrative Revealing the neural mechanisms that underlie ramping activity in dopamine neurons will have relevance for understanding the neural basis of cognitive control, goal-directed behavior, perseverance, and spatial learning. Our findings will provide valuable new information relevant for mental disorders associated with dysfunction in these abilities including attention deficit hyperactivity disorder, obsessive compulsive disorder, depression, and addiction.

PI_NAMEs: WARDEN, MELISSA RHOADS (contact)

PROGRAM_OFFICER_NAME: NAIR, SUNILA GOPI

PROJECT_TERMS: addiction;Address;Animals;Attention deficit hyperactivity disorder;Behavior;Brain region;cognitive control;Corpus striatum structure;Distant;Dopamine;dopaminergic neuron;Environment;Evolution;experience;Functional disorder;Future;gamma-Aminobutyric Acid;Goals;Hippocampus;interest;Learning;Location;Mental Depression;Mental disorders;Midbrain structure;Modeling;Mus;neural;neural circuit;neuromechanism;Neurons;Obsessive-Compulsive Disorder;Play;Ramp;Regulation;Rewards;Rodent;Role;Running;Sensory;Stretching;Testing;Training;Ventral Striatum;Ventral Tegmental Area

PROJECT_TITLE: Neural circuit regulation of ramping activity in dopamine neurons

STUDY_SECTION: LMDN

STUDY_SECTION_NAME: Learning, Memory and Decision Neuroscience Study Section[LMDN]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Pediatric;Physical Injury - Accidents and Adverse Effects;Social Determinants of Health;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury;Unintentional Childhood Injury

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE. Of the millions of American schoolchildren who suffer concussions each year, approximately one quarter experience persistent physical, emotional, and/or cognitive symptoms, which can affect their quality of life, academic performance, social behavior, and psychological well-being. This project will measure concussion symptoms, biological markers, and academic and social factors across the first year postconcussion to develop a model that enables early identification of and symptom management for children at higher risk for persistent postconcussive symptoms. Findings will provide novel insights into the longer-term effects of concussion on children's physical, psychological, and social well-being and support the development of personalized healthcare and school-based plans to reduce disparities in children's ability to return-to-learn and -play and improve postconcussion quality of life.

PI_NAMEs: REUTER-RICE, KARIN  (contact)

PROGRAM_OFFICER_NAME: AWWAD, HIBAH OMAR

PROJECT_TERMS: Absenteeism;acute symptom;Adult;Affect;Age;American;Biological;Biological Markers;Brain Concussion;Brain Injuries;care outcomes;Characteristics;Child;Childhood;Clinical;clinical care;clinical prognostic;Cognitive;cognitive function;concussive symptom;cost estimate;cytokine;Data;demographics;Development;Diagnosis;disparity reduction;Early identification;Economic Burden;Emergency department visit;Emotional;emotional symptom;ethnic diversity;evidence base;experience;Family;Fatigue;Genes;Goals;Growth;Health;health care delivery;health disparity;health economics;Healthcare Systems;high risk;improved;improved outcome;Inflammatory;Injury;insight;Intervention;Learning;Link;Measures;meetings;Modeling;Neurobehavioral Manifestations;novel;Outcome;outcome disparities;Patient Outcomes Assessments;Patient Self-Report;Pattern;peer;Performance;persistent symptom;personalized care;personalized health care;physical symptom;Play;Population Heterogeneity;Post-Concussion Syndrome;Process;psychologic;psychological distress;Public Health;Quality of life;racial diversity;Reporting;Research;response;Risk;risk stratification;Schools;Severities;Sex Distribution;social;Social Behavior;social factors;Social isolation;Social outcome;Social Well-Being;societal costs;socioeconomics;symptom management;symptom science;Symptoms;Time;Typology;United States National Institutes of Health;Variant;Well in self;Work

PROJECT_TITLE: A Risk Stratification Model for Health and Academic Outcomes in Children with Concussion Based on Novel Symptom Trajectory Typologies

STUDY_SECTION: CMGC

STUDY_SECTION_NAME: Clinical Management in General Care Settings Study Section[CMGC]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

ORG_CITY: BATON ROUGE

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: LOUISIANA STATE UNIV A&M COL BATON ROUGE

ORG_STATE: LA

PHR: PROJECT NARRATIVE Electronic nicotine delivery systems (ENDS), including electronic-cigarettes and JUUL devices, have become increasingly popular among smoking and non-smoking pre-teens, teenagers and adults. Little, however, is known about the long-term cardiopulmonary effects of ENDS aerosols. We will use ENDS exposure systems we have developed, combined with biomarkers of toxicity and physiological changes found in dual-users (cigarette plus ENDS), to predict early signs of cardiopulmonary toxicity induced by sole exposures to ENDS aerosols.

PI_NAMEs: NOEL, ALEXANDRA  (contact)

PROGRAM_OFFICER_NAME: LU, QING

PROJECT_TERMS: Acute-Phase Proteins;Address;Adult;Aerosols;Age;Air;Aldehydes;American;asthmatic;Award;base;Bioinformatics;Biological Assay;Biological Markers;Biology;biomarker identification;biomarker panel;Blood Vessels;Canada;Candy;Cardiopulmonary;cardiovascular effects;Cardiovascular system;career;career development;Categories;Cell Survival;Cells;Characteristics;Chemicals;Chronic;Cigarette;cigarette smoke;cigarette smoking;cigarette user;Clinical;Complement;cytotoxicity;design;Development;Devices;Doctor of Philosophy;e-cigarette aerosols;early detection biomarkers;Electronic cigarette;electronic liquid;Electronic Nicotine Delivery Systems;Endothelial Cells;Endothelium;environmental tobacco smoke;Epithelial Cells;Evaluation;Exposure to;Female;Fibrinogen;Flavoring;Flow Cytometry;Fruit;Funding;Future;Gene Expression;Generations;Genes;genotoxicity;Goals;Health;Health Policy;Heart;High Pressure Liquid Chromatography;High School Student;Human;Immune;Immunity;Immunology;Immunosuppression;In Vitro;in vitro Model;in vivo;in vivo Model;Individual;Inflammation;inflammatory marker;Inhalation;Inhalation Exposure;Inhalation Toxicology;innovation;Institution;JUUL;JUUL vapor;Knowledge;Learning;Liquid substance;Louisiana;Lung;lung development;lung health;Mainstreaming;male;Measures;Mentors;Middle School Student;mouse model;Mus;Myocardial Infarction;nano-string;nanoparticle;Nicotine;non-cigarette tobacco product;non-smoking;Oxidative Stress;P-Selectin;Peptidyl-Dipeptidase A;Phenotype;Physiological;Plasma;Play;Population;preadolescence;predictive marker;Predictive Value;Prevalence;professor;programs;Propylene Glycols;protein expression;Public Health;Publishing;pulmonary function;Pulmonary Heart Disease;Recovery;Regulation;Renin;Renin-Angiotensin System;Reporting;Research;response;Risk;Role;Science;Scientist;Smoking;Sodium Chloride;Solid;Stephania;Structure;Supervision;symposium;System;systemic inflammatory response;Techniques;Teenagers;Testing;Time;titanium dioxide;Tobacco;tobacco exposure;tobacco products;tobacco regulatory science;Toxic effect;Training;Training Activity;Universities;vegetable glycerin;von Willebrand Factor;Vulnerable Populations;Western Blotting

PROJECT_TITLE: Cardiopulmonary effects induced by electronic-cigarette and JUUL aerosols in both in vivo and in vitro models.


NIH_SPENDING_CATS: Cancer;Emerging Infectious Diseases;Genetics;HIV/AIDS;Hematology;Infectious Diseases;Lymphatic Research;Lymphoma;Orphan Drug;Rare Diseases

ORG_CITY: CHICAGO

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Kaposi’s sarcoma-associated herpesvirus (KSHV) is a major cause of AIDS-associated malignancies and thus represents a significant public health burden. The proposed work will identify specific genes and DNA elements that mediate the cancerous reprogramming that occurs in KSHV-associated B cell lymphomas. Results will be impactful, because they will be used to develop therapeutic strategies for this presently incurable cancer.

PI_NAMEs: GOTTWEIN, EVA HENRIETTE (contact)

PROGRAM_OFFICER_NAME: READ-CONNOLE, ELIZABETH LEE

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;AIDS related cancer;B Cell Proliferation;B-Cell Lymphomas;B-Lymphocytes;BCL2L11 gene;Blood typing procedure;Bromodomains and extra-terminal domain inhibitor;Cancer Etiology;Cancerous;candidate identification;CCND2 gene;Cell Line;Cell Proliferation;Cell Survival;Cellular biology;ChIP-seq;cofactor;Complex;Data;Dependence;Distal;DNA;Drug Addiction;Drug Targeting;effusion;Elements;Enhancers;Environment;Epigenetic Process;Event;Exhibits;experimental study;functional genomics;Gene Expression;Genes;Genetic Transcription;Genomic approach;Hematopoietic Neoplasms;HIV/AIDS;Homologous Gene;Human;Human Herpesvirus 8;immune modulating agents;improved;In Vitro;in vivo;Individual;innovation;Interferons;IRF4 gene;Lymphoid;Lymphoma cell;Malignant Neoplasms;Mediating;Mediator;Molecular;mRNA sequencing;MYC gene;neoplastic cell;novel;novel therapeutic intervention;Oncogenic;Outcome;overexpression;primary effusion lymphoma;programs;Proliferating;promoter;Public Health;Regulatory Element;Repression;Response Elements;Role;synergism;Test Result;Testing;Therapeutic;therapeutic candidate;Therapeutic Intervention;transcription factor;Transcriptional Regulation;transcriptional reprogramming;Transcriptional Silencer Elements;Tumor Suppressor Proteins;Viral;viral interferon regulatory factor;viral interferon regulatory factor-3;Work

PROJECT_TITLE: Transcriptional Control of Cellular Survival and Proliferation in KSHV-transformed B Cells

STUDY_SECTION: HCAC

STUDY_SECTION_NAME: HIV Coinfections and HIV Associated Cancers Study Section[HCAC]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Macromolecules play key roles in nearly all biological processes, and thus understanding their structure and function is critical to human health. Determining structures of macromolecules would be highly beneficial for elucidating mechanisms of human disease and designing countermeasures. Despite recent advances, many health-relevant macromolecules remain difficult to study. We propose to use DNA nanotechnology to gain programmable spatial control over these targets to their enable structure determination.

PI_NAMEs: DOUGLAS, SHAWN M (contact)

PROGRAM_OFFICER_NAME: FLICKER, PAULA F

PROJECT_TERMS: 3-Dimensional;Address;Amino Acids;Antifungal Therapy;Bar Codes;Binding;Binding Sites;Biological Process;Complex;Computer Models;Computer Simulation;Computer software;Cryoelectron Microscopy;Custom;design;Devices;Diabetes Mellitus;DNA;DNA Binding;DNA-Binding Proteins;Docking;Drug resistance;Engineering;Excision;flexibility;Future;Generations;Health;Human;human disease;Image;improved;Individual;Inflammatory Bowel Diseases;instrument;Link;macromolecule;Malignant Breast Neoplasm;Malignant neoplasm of pancreas;Microscopy;Modification;Molecular;Nanostructures;Nanotechnology;non-alcoholic fatty liver disease;Nuclear Receptors;particle;Play;Preparation;prevent;Proteins;reconstruction;Rotation;Sampling;Side;Structure;System;Techniques;tool;transcription factor;Variant;Visualization;X-Ray Crystallography;Yeasts

PROJECT_TITLE: DNA Nanostructures for High-Throughput Cryo-EM Studies of Small Macromolecules