NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Childhood Injury;Chronic Pain;Clinical Research;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Neurosciences;Pain Research;Pediatric;Prevention;Suicide;Suicide Prevention

ORG_CITY: RESEARCH TRIANGLE PARK

ORG_NAME: RESEARCH TRIANGLE INSTITUTE

PHR: PROJECT NARRATIVE Findings will advance understanding beyond the pain–suicidality link by pinpointing (a) proximal factors predicting when suicidal ideation (SI) occurs (i.e., in moments of social threat or physical pain), (b) neural vulnerability markers identifying who develops SI, and (c) how SI may develop through interactions between negative social environments and altered function in the pain system. Findings will inform novel targets for just- in-time interventions that deliver skills through electronic devices in critical moments of risk. Additionally, findings may help refine or augment other existing interventions for SI among vulnerable youth by integrating treatment components that target physical pain in the context of social threat, such as cognitive-behavioral therapies established for pain, or non-invasive fMRI real-time neurofeedback in which youth learn to regulate brain activation in key pain-related brain regions.

PI_NAMEs: OPPENHEIMER, CAROLINE  (contact);PHILLIPS, MARY LOUISE

PROGRAM_OFFICER_NAME: MURPHY, ERIC ROUSSEAU

PROJECT_TERMS: 10 year old;Address;Adolescence;Adolescent;Adult;Affective;Age;American;American Psychiatric Association;Anterior;Back;Back Pain;Behavior;biomarker identification;Brain;brain based;Brain region;Cause of Death;Child;chronic pain;cingulate cortex;Cognitive Therapy;Cross-Sectional Studies;Data;design;Development;Diagnosis;diaries;Dimensions;Distress;Ecological momentary assessment;Electronics;Exhibits;experience;Exposure to;Feeling;Feeling suicidal;Foundations;Functional Magnetic Resonance Imaging;Health Care Costs;Hour;Individual;Individual Differences;Injury;Insula of Reil;Intervention;Investigation;Knee;Knowledge;Learning;Life;Limb structure;Link;Longitudinal Studies;Measures;Mediation;Methods;Modeling;Morbidity - disease rate;mortality risk;Musculoskeletal Pain;Neck;neural;neurofeedback;neuroimaging;novel;Outcome;Pain;Pathway interactions;peer;Predictive Factor;Reaction;recruit;Recurrence;Research;response;Risk;Risk Factors;Role;Sampling;Severities;skills;social;Social Environment;social relationships;Social status;Stimulus;suicidal;suicidal behavior;suicidal risk;Suicide;Suicide prevention;suicide rate;System;Testing;theories;Thinking;Time;Work;World Health Organization;Youth

PROJECT_TITLE: Moving beyond the Pain-Suicidality Link: An Investigation of Fluctuations in Social Threat and Neural Response to Social Threat in Momentary Pain and Proximal Risk for Suicidal Ideation in Adolescence

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


ADMINISTERING_IC: GM

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: NEW HAVEN

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOCHEMISTRY

ORG_FIPS: US

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative This application proposes to train graduate students to become independent scientists in modern experimental and computational biophysics. This biophysical training is essential to understand the function of all biological macromolecules. This understanding is crucial to deciphering how aberrant biological processes cause disease and this understanding will benefit human health.

PI_NAMEs: XIONG, YONG  (contact);YAN, ELSA CHUI YING

PROGRAM_OFFICER_NAME: STAMM, JOYCE CHIN-CHIN NG

PROJECT_TERMS: Biophysics;pre-doctoral;programs

PROJECT_TITLE: Predoctoral Program in Biophysics

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - B[TWD-B]


NIH_SPENDING_CATS: Chronic Pain;Pain Research

ORG_CITY: PITTSBURGH

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project Narrative Each year in the US, anesthesiologists provide indispensable professional services in ~50 million medical procedures and treat acute and chronic pain associated with these procedures and many diseases such as cancer. The very best physician scientists are needed to lead the future intellectual pursuits in anesthesiology and pain medicine and to translate research findings into improved clinical outcomes. The proposed Kirschstein National Research Service Award Program at the University of Pittsburgh will continue the successful tradition of creating the best possible academic environment and opportunities to train anesthesiologists and postdoctoral research scientists to become leaders in the field of anesthesiology and perioperative medicine.

PI_NAMEs: XU, YAN  (contact)

PROGRAM_OFFICER_NAME: PAUL, MOUSHUMI

PROJECT_TITLE: Research Training in Anesthesiology and Pain Medicine


ADMINISTERING_IC: HL

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Hematology;Pediatric;Prevention;Rare Diseases;Sickle Cell Disease

ORG_CITY: ABUJA

ORG_COUNTRY: NIGERIA

ORG_FIPS: NI

ORG_NAME: UNIVERSITY OF ABUJA

PHR: PROJECT NARRATIVE The Sickle Pan African Research Consortium NigEria Network (SPARC-NEt) hub at the Centre of Excellence for Sickle Cell Disease Research and Training, University of Abuja (CESRTA) has 18 satellite sites across the six geo-political zones of Nigeria. This spread is important to achieve SPARC-NEt’s goal of expanding its SCD patient cohort from 6000 to 9,000 (including 1,000 newborns), training health care workers and stakeholders to offer improved care to patients with SCD and carrying out studies aimed at assessing how patients with SCD in Nigeria will respond to standard treatment known to be effective in SCD populations in developed countries. We also plan to use genomic technologies to investigate the association between changes in gut microbiome, protective fetal hemoglobin levels and frequency of sickle cell crisis in new born babies followed up for five years.

PI_NAMEs: NNODU, OBIAGELI EUNICE (contact)

PROGRAM_OFFICER_NAME: LOUDEN, ANDREW

PROJECT_TERMS: 5 year old;Address;Adopted;Advocacy;Africa;Africa South of the Sahara;African;Anemia;Award;Bioinformatics;Biological;Birth;burden of illness;Caring;Case Report Form;Characteristics;Child;Chronic;Clinical;clinical phenotype;Clinical Research;Clinical Sciences;cohort;Cohort Studies;Collaborations;Country;Data Coordinating Center;data registry;Databases;Demographic and Health Surveys;Developed Countries;Disease;Early Diagnosis;Educational Curriculum;epidemiology study;Ethics;Event;experience;Fetal Hemoglobin;follow-up;Frequencies;Funding;Genomic approach;Genomics;Ghana;Goals;Guidelines;gut microbiome;Health;health management;Health Personnel;health training;Healthcare;Hematology;Hemoglobin concentration result;High Prevalence;hydroxyurea;implementation study;improved;Incidence;Individual;Infection;Infrastructure;Intervention;Knowledge;Master of Science;Medicine;Mendelian disorder;Morbidity - disease rate;mortality;National Heart, Lung, and Blood Institute;Neonatal Screening;Newborn Infant;Nigeria;Outcome;Parents;Patient Recruitments;Patients;Peer Review;Penicillins;Phase;Phenotype;Policies;Population;Predisposition;primary health center;Prophylactic treatment;Publications;Quality of life;recruit;Research;Resources;Sampling;Sickle Cell;Sickle Cell Anemia;sickle cell crisis;sickling;Site;skills;Societies;standard care;standard of care;Strategic Planning;stroke risk;Structure;success;Support Groups;Supporting Cell;Supportive care;Tanzania;Technology;Training;Translational Research;United States National Institutes of Health;Universities;vaso-occlusive crisis;Work;working group

PROJECT_TITLE: Sickle Pan African Research Consortium Nigeria (SPARC-NEt)


ADMINISTERING_IC: AG

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: INDIANAPOLIS

ORG_DEPT: GENETICS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: PROJECT NARRATIVE  This application proposes to renew the National Centralized Repository for Alzheimer Disease and Related Dementias (NCRAD), an NIA funded biorepository for dementia-related studies. NCRAD’s ultimate goal is to support the development of new treatments for Alzheimer disease and related dementias (ADRD). NCRAD will work closely with the NIA, studies banking samples, and researchers requesting samples, to ensure that the biospecimens banked at NCRAD are collected in a uniform fashion, are of the highest quality and are distributed to facilitate ADRD research.

PI_NAMEs: FOROUD, TATIANA M. (contact)

PROGRAM_OFFICER_NAME: ELLIOTT, CERISE

PROJECT_TERMS: Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Area;biobank;Biological Markers;Biological Specimen Banks;biomarker development;blood-based biomarker;brain tissue;Cell Line;Cerebrospinal Fluid;Communities;Data;Dementia;Development;Diagnosis;Disease;disorder risk;DNA;Down's Syndrome;Early Diagnosis;Ensure;Etiology;exome sequencing;experience;Family;Fibroblasts;Fostering;Frontotemporal Dementia;Funding;gene discovery;Genes;Genetic;Genetic Diseases;genetic risk factor;genome sequencing;genome-wide;Genomics;Goals;Growth;induced pluripotent stem cell;innovation;interest;Longevity;Manuscripts;material transfer agreement;Mutation;National Institute on Aging;novel strategies;Paper;Parkinson Disease;Participant;Peripheral Blood Mononuclear Cell;Persons;Plasma;Play;Population;prevent;programs;Qualifying;REM Sleep Behavior Disorder;repository;Research;Research Personnel;Resources;response;RNA;Role;Sampling;Serum;Services;SNP genotyping;Specimen;success;Technology;TFF1 gene;Therapeutic;U-Series Cooperative Agreements;United States;user-friendly;Work

PROJECT_TITLE: National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD)

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Clinical and Translational Research of Aging Study Section[NIA -T]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Aging;Alcoholism, Alcohol Use and Health;Drug Abuse (NIDA only);Neurosciences;Substance Misuse

ORG_CITY: PHILADELPHIA

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE This predoctoral training program provides broad, rigorous, and quantitative training in basic neuroscience research. A primary goal of our program is to train the next-generation of scientific leaders who will focus their careers on developing new approaches to diagnose and treat disorders of the nervous system, including stroke, epilepsy, traumatic brain injury, neurodegenerative disorders, and addiction.

PI_NAMEs: FUCCILLO, MARC V;MA, MINGHONG  (contact)

PROGRAM_OFFICER_NAME: WEIGAND, LETITIA ALEXIS

PROJECT_TERMS: Neurosciences;Training

PROJECT_TITLE: Graduate Training in Neuroscience


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE  The current cycle of AG011378 was designed to test aspects of a hypothetical model of the temporal evolution of Alzheimer’s biomarkers that we proposed; however, a major missing element when the current cycle of AG011378 began was a method to measure fibrillar tau deposits with imaging. Tau PET has recently become available and consequently for the first time imaging biomarkers exist to ascertain three of the most important pathologic features of AD: amyloid, tau and neurodegeneration. Our aims in this renewal application are to empirically evaluate our hypothetical model of AD biomarkers and to create new imaging biomarker models for individuals who are not in the Alzheimer’s continuum using imaging measures of amyloid, tau, and neurodegeneration.

PI_NAMEs: JACK, CLIFFORD R. (contact)

PROGRAM_OFFICER_NAME: HSIAO, JOHN

PROJECT_TERMS: Affect;Age;age related;Aging;aging population;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's Disease Pathway;Alzheimer’s disease biomarker;Amyloid;Amyloidosis;Biological;Biological Markers;Brain;Characteristics;Clinical;Cognitive;Cognitive aging;cognitive change;cohort;Dementia;Deposition;design;Disease Pathway;Education;Elderly;Elements;Evolution;fluorodeoxyglucose positron emission tomography;Future;Goals;Grant;Image;imaging biomarker;imaging modality;Impaired cognition;Individual;insight;Label;Ligands;Magnetic Resonance Imaging;markov model;Measures;Methods;Modality;Modeling;Nerve Degeneration;non-demented;Pathologic;Pathologic Processes;Pathway interactions;Population;population based;Positron-Emission Tomography;Probability;Publishing;segregation;sex;Symptoms;tau aggregation;tau Proteins;Tauopathies;Testing;Time

PROJECT_TITLE: Disease pathways in the population determined by amyloid, tau, and neurodegeneration imaging biomarkers

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: HINES

ORG_NAME: EDWARD HINES JR VA HOSPITAL

ORG_STATE: IL

PHR: Prostate cancer is the most diagnosed cancer in the VA Healthcare System. Unfortunately, in 20% of Veterans who have curative treatment for prostate cancer, the cancer later spreads to other parts of the body, and half of these men will die of cancer. New treatments are needed to help improve the survival of these Veterans. Promising evidence suggests that men with limited areas of spread may benefit from further radiation or surgery to these new areas. However, the benefit is unknown when Veterans are receiving hormonal or chemohormonal therapy. Our study will determine whether adding radiation or surgery to the areas of spread in Veterans re- ceiving hormonal or chemohormonal therapy reduces the chance of further growth of the can- cer. We will also study how the treatments impact the Veteran’s quality of life and how genetic changes in the tumor can determine who benefits most from the combined treatment approach.

PI_NAMEs: SOLANKI, ABHISHEK ASHOK (contact)

PROJECT_TERMS: Adoption;Androgen Receptor;Area;biomarker identification;biomarker selection;Body part;Cancer Control;cancer diagnosis;Cancer Etiology;Cessation of life;Characteristics;chemotherapy;Clinical;Clinical Trials Design;Collaborations;Combined Modality Therapy;comparison control;cooperative study;cost effectiveness;curative treatments;Data;Development;Disease;Disease Outcome;disorder control;DNA sequencing;economic evaluation;Effectiveness;Eligibility Determination;Enrollment;Failure;Goals;Growth;health economics;health related quality of life;Healthcare Systems;Hormonal;hormone therapy;Image;improved;improved outcome;Institution;Interdisciplinary Study;Local Therapy;Malignant neoplasm of prostate;Malignant Neoplasms;Measures;men;Metastatic Prostate Cancer;Metastatic/Recurrent;Methodology;Molecular;molecular subtypes;mortality;Mutation;Neoplasm Metastasis;novel;novel therapeutics;oncology program;Operative Surgical Procedures;Outcome;palliative;Patient Selection;patient subsets;Patients;Pattern;Phase;phase III trial;Positron-Emission Tomography;precision oncology;prevent;primary endpoint;Primary Neoplasm;programs;Progression-Free Survivals;Prostate;Prostate Cancer therapy;Quality of life;Radiation;Radiation therapy;randomized trial;Recurrence;response;RNA;Site;standard of care;Systemic Therapy;targeted agent;Testing;Therapeutic Agents;transcriptomics;trial comparing;tumor;Tumor Markers;tumor progression;United States Department of Veterans Affairs;Veterans;Vitelliform macular dystrophy;Widespread Disease

PROJECT_TITLE: Veterans Affairs seamless phase II/III randomized trial of STAndard systemic theRapy with or without PET-directed local therapy for OligoRecurrenT prostate cancer (VA STARPORT)


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Immunotherapy;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza;Rare Diseases

ORG_CITY: SEATTLE

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE Lower respiratory tract infections, such as community-acquired pneumonia, represent a major cause of hospitalization and death worldwide. This project seeks to understand the role of specific cells of the immune system, termed innate-like lymphocytes, in early pneumonia. The results of this proposal will provide the basis for new treatments and management approaches for severe pneumonia.

PI_NAMEs: WRIGHT, SHELTON WILEY (contact)

PROGRAM_OFFICER_NAME: ESPINOZA-PINTUCCI, MARISOL

PROJECT_TERMS: Address;Aerosols;Animal Model;Applications Grants;Bacteria;Bacterial Vaccines;bioweapon;Blood donor;Burkholderia;Burkholderia pseudomallei;career development;Cells;Cessation of life;Characteristics;Childhood;cohort;community acquired pneumonia;Complement;Containment;Critical Illness;cytokine;Data;Development;Development Plans;differential expression;Disease;disease model;Fatality rate;Fc Receptor;Gene Expression;Genes;Goals;Health;Hospitalization;Host Defense;Host resistance;Human;human model;IL17 gene;Immune response;Immune system;Immunology;immunomodulatory therapies;Immunotherapy;Impairment;improved;in vivo;Infection;Inflammation;Inflammatory;Inflammatory Response;innovation;insight;Intensive Care;Interferon Type II;K-Series Research Career Programs;knockout animal;Leukocytes;Lower Respiratory Tract Infection;Lung;Lung infections;Lymphocyte;Melioidosis;Mentors;Mentorship;Methods;Modeling;mouse model;Mucous Membrane;multidisciplinary;Mus;neutrophil;Neutrophil Infiltration;novel;novel therapeutic intervention;pathogen;Patient Recruitments;Patients;Peripheral;peripheral blood;Phenotype;Physicians;Play;Pneumonia;pneumonia model;Positioning Attribute;Process;programs;Prospective Studies;Pulmonary Inflammation;Receptor Cell;Research;Research Personnel;Research Project Grants;Role;Scientist;single-cell RNA sequencing;skills;Soil;T cell response;T-Cell Activation;T-Cell Receptor;T-Lymphocyte Subsets;Testing;Therapeutic;Tissues;Training;Training and Infrastructure;Training Programs;transcriptomics;translational approach;translational physician;translational research program;translational scientist;United States;Universities;Washington;γδ T cells

PROJECT_TITLE: Pulmonary gamma-delta T cells in lung infection

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(JA)]


NIH_SPENDING_CATS: Mental Health;Neurosciences

ORG_CITY: Aurora

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative  The purpose of this grant is to provide financial support for the training of Neuroscience Ph.D. students in their first two years of graduate school. Graduates who emerge from our program will be qualified to conduct independent research in basic neuroscience at a variety of levels, as well as in disorders of the nervous system. The development of therapies for brain disorders is dependent on a well-trained workforce of neuroscientists.

PI_NAMEs: PERSON, ABIGAIL L;SCHOPPA, NATHAN ERIC (contact)

PROJECT_TERMS: Grant;Neurosciences;Training

PROJECT_TITLE: Neuroscience Training Grant


ORG_CITY: AUGUSTA

ORG_NAME: AUGUSTA UNIVERSITY

ORG_STATE: GA

PHR: NARRATIVE Hypertension is a major cause of global mortality and a primary modifiable risk factor for renal, cardiovascular and cerebrovascular disease. The present studies will address a significant knowledge gap by directly assessing the mechanisms whereby immune cells lead to salt-sensitive hypertension and kidney damage. Results of this work will transform the understanding of immune mechanisms in salt-sensitive hypertension by utilizing novel animal models and approaches, revealing new paradigms, and providing insight with the potential to transform clinical/therapeutic approaches for the treatment of disease.

PI_NAMEs: MATTSON, DAVID L. (contact)

PROGRAM_OFFICER_NAME: VARAGIC, JASMINA

PROJECT_TERMS: Address;Animal Model;Anti-Hypertensive Agents;Attenuated;blood pressure elevation;Bone Marrow;Cardiovascular Diseases;cardiovascular risk factor;Cell Separation;Cells;Cerebrovascular Disorders;Clinical;Conscious;cytokine;Dahl Hypertensive Rats;Data;Development;Disease;Diuresis;Exhibits;experimental study;Female;Free Radicals;Genetic;Genetic Engineering;Grant;Hematopoietic;hemodynamics;Human;Hypertension;hypertensive;hypertensives;Immune;Immunity;In Vitro;in vivo;Individual;Inflammation;Inflammatory;insight;Intake;Interleukin-1 beta;Kidney;Kidney Diseases;Knowledge;Lead;Leukocytes;Macrophage;male;Mediating;Methodology;Modeling;modifiable risk;mortality;NADPH Oxidase;Natriuresis;neutrophil cytosol factor 67K;novel;Organ;Pathogenesis;Phagocytes;Plasma;Population;pressure;Process;Production;protective effect;Proteins;Rat Strains;Rattus;Reactive Oxygen Species;receptor;renal damage;Resistance;Resistant Hypertension;response;Risk Factors;Role;salt sensitive;salt sensitive hypertension;saluretic;sex;Signal Transduction;Sodium Chloride;T cell therapy;T-Cell Activation;T-Lymphocyte;Testing;Therapeutic;TLR4 gene;Work

PROJECT_TITLE: CD14 and Salt-Sensitive Hypertension

STUDY_SECTION: IVPP

STUDY_SECTION_NAME: Integrative Vascular Physiology and Pathology Study Section[IVPP]


ADMINISTERING_IC: NR

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Clinical Research;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Lung;Machine Learning and Artificial Intelligence;Prevention;Rare Diseases

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: Project Narrative Nearly half a million people each year lose their ability to breath on their own and are treated by placing a breathing tube in their throat. After regaining their ability to breath, as many as 44% of patients may have trouble swallowing. This proposal will identify modifiable factors, determine the optimal screening tool, and classify specific groups of patients who may have different rates of recovery of their swallowing difficulties. Overall, this research will improve the care of patients recovering from critical illnesses and pave the way for the discovery of novel treatments for their swallowing dysfunction.

PI_NAMEs: MOSS, MARC  (contact)

PROGRAM_OFFICER_NAME: SEAY, JULIA SUSAN

PROJECT_TERMS: acute care;Acute respiratory failure;Admission activity;Algorithms;aspirate;Boston;Breathing;Caregiver Burden;Classification;Cohort Studies;Colorado;Confounding Factors (Epidemiology);cost;Critical Illness;Decision Trees;Deglutition;Deglutition Disorders;Development;Diagnosis;Diagnostic tests;Diameter;Dyes;endotracheal;Enteral;Enteral Feeding;Epidemiology;Evaluable Disease;Evaluation;Exploratory/Developmental Grant for Diagnostic Cancer Imaging;feeding;Fiber Optics;Focus Groups;Functional disorder;Funding;Health;Health care facility;high risk;Hospital Mortality;improved;infancy;Infrastructure;innovation;interest;Intratracheal Intubation;Intubation;Journals;Language;Larynx;Life;Long-Term Care;Measures;Mechanical ventilation;Medicine;Methods;modifiable risk;Mosses;multidisciplinary;New England;novel;nutrition;Oral;Pathologist;Patient Care;Patient-Focused Outcomes;Patients;personalized medicine;Persons;Pharyngeal structure;Pneumonia;pressure;prevent;Procedures;Process;prospective;Prospective Studies;Quality of life;Recovery;Research;Risk;Risk Factors;screening;Screening procedure;Speech;Structure;Survivors;targeted treatment;Testing;Therapeutic;tool;Trachea;Tube;ultrasound;Universities;Water;Work

PROJECT_TITLE: Aspiration in Acute Respiratory Failure Survivors

STUDY_SECTION: HSQE

STUDY_SECTION_NAME: Health Services: Quality and Effectiveness Study Section[HSQE]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: HONOLULU

ORG_DEPT: NUTRITION

ORG_NAME: UNIVERSITY OF HAWAII AT MANOA

ORG_STATE: HI

PHR: PROJECT NARRATIVE Native Hawaiians’ traditional lifestyles and diets that ensured mutual health and wellbeing of the land and its inhabitants stand in stark contrast to the disproportionately high prevalence of diet-related, cardiometabolic diseases they experience today. In this project, we will adapt and test an evidence-based multilevel intervention entitled PILI ‘Āina to improve the self-management of prevalent cardiometabolic diseases and reduce risk factors for developing new diet-related illness and implement and evaluate the impact and sustainability of community- wide cooking demonstrations. The objectives of this project are to optimize the effectiveness and sustainability of PILI ‘Āina, improve diet quality and cardiometabolic markers and promote traditional Native Hawaiian diets and improve social cohesion.

PI_NAMEs: ING, CLAIRE TOWNSEND (contact)

PROGRAM_OFFICER_NAME: PUGGAL, MONA A

PROJECT_TERMS: access restrictions;Adult;African American;American Heart Association;base;Behavior;Behavioral;behavioral outcome;Biological Markers;Blood Glucose;blood lipid;Blood Pressure;Body Weight decreased;Cardiometabolic Disease;cardiometabolism;Cardiovascular Diseases;cardiovascular health;Communities;community based participatory research;community partners;Consumption;Control Groups;cooking;Data;Data Collection;Diabetes Mellitus;diabetes prevention program;Diet;dietary;Dietary Intervention;Disease;disorder risk;Disparity;Dose;Dyslipidemias;Eating;Education;Educational Intervention;Effectiveness;efficacy testing;Ensure;Ethnic Population;European;Event;evidence base;Evidence based program;Exertion;experience;Family member;Fishes;Food;Fostering;Fruit;fruits and vegetables;Funding;Glycosylated hemoglobin A;good diet;Harvest;Hawaii;Hawaiian;Health;Health behavior;Health Food;Healthy Eating;High Prevalence;Home;Home environment;Household;Hyperlipidemia;Hypertension;impaired glucose tolerance;improved;indexing;Indigenous;Individual;Inequity;Intervention;intervention refinement;Interview;Lead;Life Style;lifestyle intervention;Lipids;Measures;Mediating;Mediation;Mediator;member;Mental Health;Morbidity - disease rate;mortality;multi-racial;Native Hawaiian;neighborhood disadvantage;Non-Insulin-Dependent Diabetes Mellitus;Not Hispanic or Latino;Nutritional;Obesity;Outcome;Overweight;Participant;participant retention;Personal Satisfaction;Persons;Physical activity;physical conditioning;Pilot Projects;Population;Prevalence;prevent;primary outcome;Process;programs;psychosocial;Psychosocial Factor;Qualifying;Quasi-experiment;racial population;Randomized;randomized trial;Randomized, Controlled Trials;Research;Research Methodology;Research Personnel;response;Risk Factors;Risk Reduction;secondary outcome;Self Efficacy;Self Management;social cohesion;Stroke;Structure;System;Taste Perception;Testing;Time;Training;United States National Institutes of Health;Vegetables

PROJECT_TITLE: The PILI 'Āina Project


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

ORG_CITY: RALEIGH

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: NORTH CAROLINA STATE UNIVERSITY RALEIGH

ORG_STATE: NC

PHR: Team-based interdisciplinary molecular medicine has become increasingly complex, teams more interdisciplinary, and communication and leadership skills more critical. This training program in Comparative Molecular Medicine addresses two critical national needs in biomedical research. First, is the growing need for developing new training approaches that better address the increasingly complex, interdisciplinary and collaborative research environment of today. Second, the need to educate PhD students that understand the ethical principles of rigor and reproducibility and responsible conduct of research and can successfully function, and become leaders, in the highly collaborative scientific environment of today that combines basic scientists, translational scientists and clinicians from many diverse backgrounds.

PI_NAMEs: FISHER, MATTHEW B;KEDROWICZ, APRIL A;LAPLANTE, CAROLINE ;PIEDRAHITA, JORGE A (contact)

PROGRAM_OFFICER_NAME: JONES, LATAISIA CHERIE

PROJECT_TITLE: Training Grant in Comparative Molecular Medicine

STUDY_SECTION_NAME: Training and Workforce Development Study Section - A[TWD-A]


NIH_SPENDING_CATS: Neurosciences

ORG_CITY: LOS ANGELES

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: The rapid development and clinical translation of neurotechnology, such as brain stimulators and devices to map and monitor the brain, has revolutionized the care of neuropsychiatric diseases. As the burden of neurological diseases on society increases at an exponential rate, society must be prepared and train future leaders who have multidisciplinary training and are prepared to develop, innovate, and translate basic neuroscientific findings into real-world neurotechnology solutions. The UCLA program, Training in Neurotechnology Translation, will serve as a training hub that will demand that trainees bridge the gap between technology and experimental science, taking advantage and building upon local expertise in relevant fields, close collaboration and interaction with industry partners, and the culture of innovation and translation that permeates UCLA.

PI_NAMEs: LU, DANIEL ;MARKOVIC, DEJAN ;SUTHANA, NANTHIA A (contact)

PROGRAM_OFFICER_NAME: REZAIZADEH, KAVON PAUL

PROJECT_TERMS: neurotechnology;Training;Translations

PROJECT_TITLE: Training in Neurotechnology Translation


NIH_SPENDING_CATS: Clinical Research;Genetics;Lung;Pulmonary Fibrosis;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

PHR: PROJECT NARRATIVE Interstitial lung diseases (ILDs) are a devastating form of chronic disease in adults and children marked by progressive respiratory failure for which there are limited therapeutics due to poorly understood disease development and progression. Activation of cell stress pathways in alveolar epithelial type 2 cells (AEC2s), an epithelial cell that line the air sacs (alveoli) of the lung, and dysfunction in their ability to repair injured lung have emerged as leading paradigms for why ILD develops and progresses. Coupling two novel mouse models that express Surfactant Protein C (SP-C) gene mutations that are associated with human ILD with state-of-the-art modeling using cells derived from an ILD patient with an SP-C mutation, we now aim to better understand ILD development and to identifying therapeutically targetable pathways by characterizing the molecular and cellular mechanisms that link AEC2 cell stress and dysfunctional lung repair.

PI_NAMEs: KATZEN, JEREMY BINDER (contact)

PROGRAM_OFFICER_NAME: GOMEZ, CHRISTIAN RENE

PROJECT_TERMS: Address;Adult;Air Sacs;Alveolar;alveolar epithelium;Alveolitis;Alveolus;Apoptosis;Apoptotic;Automobile Driving;Autophagocytosis;Bioinformatics;biological adaptation to stress;Cell Culture Techniques;Cell Line;Cell model;Cell Proliferation;Cells;Cellular biology;Cellular Stress;Child;Chronic Disease;citrate carrier;Coupled;Coupling;Data;Defect;Development;Disease;disease model;endoplasmic reticulum stress;Epithelial Cells;Epithelium;Fibrosis;fibrotic interstitial lung disease;fibrotic lung disease;Functional disorder;Gene Mutation;Generations;Genes;Genetic;Human;human disease;In Vitro;in vivo;in vivo Model;Induced Mutation;Inflammation;inhibition of autophagy;Injury;injury and repair;interstitial;Interstitial Lung Diseases;Knock-in;Knock-in Mouse;Link;Lung;Lung Diseases;lung injury;lung repair;Mesenchymal;Mesenchyme;Modeling;Molecular;mouse model;multimodality;Mus;mutant;Mutate;Mutation;novel;Organoids;Pathogenesis;Pathologic;Pathway interactions;patient subsets;Patients;pharmacologic;Phenotype;Play;pre-clinical;Pre-Clinical Model;progenitor;Prognosis;programs;Proliferating;Protein Isoforms;Proteins;Publishing;Pulmonary Fibrosis;Pulmonary Pathology;Pulmonary Surfactant-Associated Protein C;repaired;Research;Respiratory Failure;Role;segregation;Signal Pathway;Signal Transduction;stem cell function;stem cells;surfactant;System;Techniques;theories;Therapeutic;therapeutic evaluation;Therapeutically Targetable;trafficking;Training;transcriptome sequencing

PROJECT_TITLE: Understanding how alveolar epithelial cell stress drives aberrant repair in interstitial lung disease

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(OA)]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Genetics;Human Genome;Pediatric

ORG_DEPT: DENTISTRY

PHR: Project Narrative Human craniofacial development is a complex process and requires suites of genes to be switched on and off at appropriate times and spaces during formation of the embryo. There is now a wealth of data available in public databases concerning which genes are expressed when and where during mammalian facial development, including for the transcription factors which are the proteins that regulate these critical expression programs, but we have not yet begun to connect this information together to derive logical predictions about the critical networks responsible for craniofacial development. This proposal will address that gap using both computational and laboratory-based methods to derive and verify transcriptional regulatory networks relevant to the genetic and molecular underpinnings of normal facial development as well as how these are disrupted to cause defects such as human orofacial clefting.

PI_NAMEs: LI, HONG  (contact)

PROGRAM_OFFICER_NAME: THIRUMANGALATHU, SHOBA

PROJECT_TERMS: Acceleration;Adopted;Affect;Age;ATAC-seq;Automobile Driving;Bioinformatics;Biological Assay;Biological Models;Biology;bone;career;career development;Cartilage;cell type;Cells;ChIP-seq;Complex;Computational Science;Computer Models;Congenital Abnormality;craniofacial;craniofacial development;critical period;Data;Data Science;Data Set;Databases;Defect;Dental;Dependence;design;Development;Development Plans;differential expression;Ectoderm;Embryo;Enhancers;Face;FaceBase;Faculty;Foundations;Future;Gene Expression;Genes;Genetic;Genetic Models;Genetic Transcription;Genome;Genomics;Goals;Growth;Histones;Human;Human Genetics;in silico;interest;Knowledge;Laboratories;Learning;Live Birth;Machine Learning;medical specialties;Mentors;Mentorship;Mesenchymal;Mesenchyme;Methods;Molecular;Morphogenesis;mouse model;Multiomic Data;Mus;Muscle;Mutant Strains Mice;National Institute of Dental and Craniofacial Research;network models;next generation;Oral;orofacial cleft;Pathology;Pattern;Performance;Population;Positioning Attribute;Process;programs;promoter;Proteins;public database;recruit;Regulatory Element;Research;Resources;Scientist;Signal Pathway;Signal Transduction;single cell ATAC-seq;single-cell RNA sequencing;Solid;spatiotemporal;Study models;System;Techniques;Technology;tenure track;Tissues;transcription factor;transcription regulatory network;Transcriptional Regulation;transcriptome;transcriptome sequencing;Transgenic Organisms;Validation

PROJECT_TITLE: Transcriptional Regulatory Networks of Craniofacial Development

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


NIH_SPENDING_CATS: Clinical Research;Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Genetics;Pediatric;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: PROJECT NARRATIVE Craniofacial skeletal muscle is essential for basic life functions including chewing, swallowing, and speaking; therefore, understanding how this tissue regenerates in response to injury and disease will provide the basis for therapeutic advances in the treatment of craniofacial muscle diseases and disorders. Our group has demonstrated that craniofacial skeletal muscle has the ability to regenerate following damage, but to what extent remains unknown. The goal of this proposal is to comprehensively investigate the regenerative capacity of craniofacial muscle and its stem cell population to inform developments in treatment modalities for individuals suffering from craniofacial muscle injury or disease.

PI_NAMEs: MCKAY, LAUREN KATZ (contact)

PROJECT_TERMS: Affect;Appearance;Basic Science;Biological Assay;Biology;Birth;Breathing;career;Cell Physiology;Cell Separation;Cell Transplantation;Cells;Cellular Assay;Clinical;craniofacial;craniofacial disorder;Data;Data Analyses;Defect;Deglutition;Development;differential expression;Discipline;Disease;Eating;effective therapy;Environment;Excision;experimental study;Face;Facial asymmetry;Foundations;Gene Expression Profile;Genes;genetic manipulation;Genomics;Goals;Impairment;Implant;In Vitro;in vivo;in vivo Model;Individual;Injury;Investigation;K-Series Research Career Programs;Knock-out;Knowledge;Lentivirus Vector;Life;Limb structure;Literature;Malignant Neoplasms;Manuscripts;Masseter Muscle;Mastication;Mediating;Mentors;Mentorship;Methodology;Modality;Modeling;Molecular;molecular phenotype;Molecular Target;Morbidity - disease rate;multidisciplinary;Muscle;Muscle Fibers;Muscle function;muscle progenitor cell;muscle regeneration;Muscle satellite cell;Muscular Dystrophies;myogenesis;Myopathy;Natural regeneration;novel;novel strategies;Oral;oral biology;orofacial;Patients;Phenotype;Population;Preparation;programs;Quality of life;regeneration potential;regenerative;Regenerative capacity;Regenerative Medicine;Regulation;Research;response to injury;restoration;Role;Scientist;single-cell RNA sequencing;skeletal;Skeletal Muscle;skills;stem;stem cell population;Stem cell transplant;stem cells;Techniques;Technology;Testing;Therapeutic;Time;tissue regeneration;Tissue-Specific Gene Expression;Tissues;Training;translational therapeutics;Trauma;tumor;Viral

PROJECT_TITLE: Myogenic Mechanisms of Craniofacial Skeletal Muscle Regeneration


ORG_CITY: BALTIMORE

ORG_DEPT: PSYCHIATRY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Pain is ubiquitous, expensive and disabling; while our knowledge of pain mechanisms has increased, advances in pain treatment remain disappointing. Given the pressing need for progress in the field of pain, it is important to develop interdisciplinary researchers capable of leading innovative studies to unravel the causes of persistent pain and discover better pain relief strategies. Our goal is to prepare the next generation of pain researchers to lead this effort.

PI_NAMEs: DONG, XINZHONG ;SMITH, MICHAEL T (contact)

PROJECT_TERMS: biobehavior;Pain Research;Training

PROJECT_TITLE: Interdisciplinary Training in Biobehavioral Pain Research


ORG_CITY: MILWAUKEE

ORG_DEPT: BIOPHYSICS

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: OVERALL NARRATIVE Calcification is a hallmark of major diseases of aging, including Age-Related Macular Degeneration (AMD) and Alzheimer's Disease (AD), disorders that are currently incurable. There is an urgent need for new therapeutic and diagnostic strategies. This program Project will investigate the biological mechanisms of calcification and their roles in the onset and etiology of AMD and AD.

PI_NAMEs: MARASSI, FRANCESCA M (contact)

PROGRAM_OFFICER_NAME: ST  HILLAIRE-CLARKE, CORYSE

PROJECT_TERMS: Age related macular degeneration;aging population;aging related;aging related disease;Alzheimer's Disease;Alzheimer's disease brain;Amyloid beta-Protein;Animal Disease Models;Animal Model;Baltimore;Biochemical;Biological;Biological Assay;Biophysics;Blindness;calcification;calcification inhibitor;calcium phosphate;California;Cell model;Cells;Clinic;Data;Dementia;Deposition;design;Development;Diagnostic;diagnostic development;diagnostic strategy;Diphosphates;Disease;disease model;Disease Progression;effective therapy;Etiology;extracellular;Eye;fluorescence imaging;Genetic;Goals;Hydroxyapatites;Image;imaging capabilities;In Situ;In Vitro;in vivo;Individual;Label;Laboratories;Lipids;Magnetic Resonance Imaging;Maryland;Medical;mineralization;Modeling;Molecular;Molecular Structure;NMR Spectroscopy;novel;novel diagnostics;novel therapeutics;Pathway interactions;Process;programs;protein purification;protein reconstitution;Proteins;Reagent;Research;Research Personnel;Role;Sampling;sensor;sensor technology;solid state nuclear magnetic resonance;synergism;tau Proteins;Testing;Therapeutic;therapeutic development;three dimensional cell culture;Tissues;tool;Universities;Validation;Vitronectin;Work

PROJECT_TITLE: Molecular mechanisms of calcification: roles and opportunities in diseases of aging


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative

PROJECT_TERMS: Advisory Committees;Age related macular degeneration;Age related pathologies;aging related disease;Alzheimer's Disease;Animals;Area;Automobile Driving;Biochemistry;Biological;calcification;calcium phosphate;Cellular biology;Collaborations;Disease Progression;Ensure;Etiology;Functional disorder;Goals;Hydroxyapatites;Individual;insight;Institution;interdisciplinary approach;Laboratories;Lipids;Medical;meetings;Mentors;mineralization;Molecular;multidisciplinary;Persons;Physiology;Process;programs;Proteins;Research;Research Personnel;Role;structural biology;Structure;success;Training;web site

PROJECT_TITLE: Core A - Administration


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Eye Disease and Disorders of Vision;Macular Degeneration;Neurodegenerative

PROJECT_TERMS: Age related macular degeneration;aging related;aging related disease;Alkaline Phosphatase;Alzheimer's Disease;Amyloid beta-Protein;Biochemical;Biological;Biological Assay;Biology;Biophysics;calcification;Cells;Chemicals;Chemistry;Cysteine;Data Analyses;data structure;design;Development;Diphosphates;Disease;Drusen;Escherichia coli;Etiology;Event;experimental study;Eye;Fluorescence Spectroscopy;Goals;Health;Hydroxyapatites;Image;imaging study;In Vitro;inorganic phosphate;intein;Isotope Labeling;Label;Length;Lipids;Mammalian Cell;Methods;Modification;Molecular;Mus;novel;Nuclear Magnetic Resonance;Nuclear Proteins;Participant;particle;Patients;Phosphorylation;Post-Translational Protein Processing;Preparation;Process;Production;Property;Proteins;Protocols documentation;Reagent;Role;Sampling;sensor;Structural Biologist;structural biology;Structure of retinal pigment epithelium;tau Proteins;Testing;Time;Tissues;tool;Validation;Vitronectin;Work

PROJECT_TITLE: Core B - Biomolecular tools


NIH_SPENDING_CATS: Aging;Biotechnology;Cardiovascular;Estrogen;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_CITY: HERSHEY

ORG_NAME: PENNSYLVANIA STATE UNIV HERSHEY MED CTR

PHR: Project Narrative Despite the knowledge that CD4+ T-cells mediate wound healing during myocardial infarction (MI) but exacerbate left-ventricular remodeling and cardiac dysfunction during heart failure (HF), the specific mechanisms that mediate this phenotypic shift in T-cell biology are not known. Our published results suggest an important role of estrogen receptor (ER) α signaling in mediating this phenotypic shift, and autoimmune activation of T-cells during chronic HF. In this proposal, PI intends to develop a novel ERβ agonist (OSU-ERb- 012), to functional oppose ERα signaling, by studying i) therapeutic efficacy of OSU-ERb-012 at clinically translatable low doses and ii) dissect, in detail, its effects on the cardiomyocytes and CD4+ T-cells using relevant cell-specific ERβ-/- HF mice.

PI_NAMEs: BANSAL, SHYAM SUNDER (contact)

PROGRAM_OFFICER_NAME: POIZAT, CORALIE ISABELLE

PROJECT_TERMS: Acute myocardial infarction;Affect;Agonist;Animal Model;Antigens;Apoptosis;Autoimmune;Biological Products;Blood capillaries;Blood Chemical Analysis;Breeding;Cardiac;Cardiac Myocytes;Cardiovascular system;CD28 gene;CD3 Antigens;CD4 Positive T Lymphocytes;Cell Separation;cell type;Cells;Cellular biology;Cicatrix;Clinic;Clinical;clinical translation;Collaborations;Congestive Heart Failure;cytokine;Data;density;Disease;Disease Progression;Dose;Drug Design;Echocardiography;ESR1 gene;Estrogen Receptor 2;Estrogen Receptors;Exhibits;Female;Fibrosis;Flow Cytometry;Genes;healing;Heart;Heart failure;heart function;Heart Injuries;Human;human induced pluripotent stem cells;Hypertrophy;Immune;immune activation;immune modulating agents;Immune response;Immunohistochemistry;Immunology;immunoregulation;improved;in vivo;induced pluripotent stem cell derived cardiomyocytes;Inflammation;Inflammatory;inhibitor;Knockout Mice;Knowledge;Left Ventricular Remodeling;Macrophage;male;Measures;Mediating;Molecular;Molecular Profiling;monocyte;mouse model;Mus;Myocardial dysfunction;Myocardial Infarction;Myocardial Ischemia;neovascularization;novel;novel therapeutics;Pathologic;Patients;Pharmaceutical Preparations;Phenotype;Physiology;prevent;Process;programs;Proliferating;Property;protective effect;Publishing;Receptor Signaling;restraint;Role;Scientist;Signal Transduction;Sorting;spatiotemporal;Specificity;T-Cell Activation;T-Cell Proliferation;T-Cell Receptor;T-Lymphocyte;Testing;Therapeutic;Toxic effect;Training;transcriptome sequencing;Translating;Treatment Efficacy;wound healing

PROJECT_TITLE: Novel Inhibitors for Temporal Modulation of T-Lymphocytes during Chronic Heart Failure

STUDY_SECTION: TDPS

STUDY_SECTION_NAME: Therapeutic Development and Preclinical Studies Study Section[TDPS]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Eye Disease and Disorders of Vision;Gene Therapy;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: AMHERST

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

ORG_STATE: NY

PHR: We recently discovered a novel form of Enhanced hammerhead ribozyme (EhhRz), an RNA therapeutic with idealized properties for cellular target mRNA knockdown (speed, concentration, specificity). Here we optimize this agent for gene or injectable nucleic acid therapeutics capacity and cellular knockdown performance, and conduct a highly focused preclinical therapeutic test to rescue retinal degeneration in a mouse model of autosomal dominant retinitis pigmentosa (adRP) that expresses human rhodopsin genes. Success would be a first step to translate EhhRz therapeutic agents into clinical trials for adRP, and validate a new nucleic acid pharmacological modality, which is highly relevant to the National Eye Institute mission.

PI_NAMEs: SULLIVAN, JOHN M. (contact)

PROGRAM_OFFICER_NAME: NEUHOLD, LISA

PROJECT_TERMS: Antisense Oligonucleotides;autosome;Binding;biophysical techniques;Biophysics;Calorimetry;Catalysis;Catalytic RNA;Cells;Cellular Stress;cellular targeting;Chemistry;Clinical;Clinical Trials;cofactor;combinatorial;comparative;Dependovirus;design;Development;Digestion;Disease;disease model;drug discovery;Elements;Engineering;Enzymes;Evaluation;Exonuclease;experimental study;Eye;Eye diseases;Frequencies;gain of function mutation;gene therapy;Genes;Goals;hammerhead ribozyme;Human;human model;humanized mouse;improved;in vivo;Incentives;inherited retinal degeneration;Injectable;innovation;intravitreal injection;Kinetics;knock-down;Lead;Length;Macular degeneration;Measures;Mediating;Messenger RNA;Mission;Modality;Modeling;Modification;Molecular;molecular dynamics;mouse model;Mus;mutant;Mutation;National Eye Institute;novel;nuclease;nucleic acid-based therapeutics;Nucleic Acids;Nucleotides;Opsin;Performance;peripherin;Pharmaceutical Preparations;pharmacologic;photoreceptor degeneration;Photoreceptors;Physiological;Population;pre-clinical;preservation;prevent;promoter;Property;protein expression;Proteins;Protons;reconstitution;Resistance;Resources;Retina;Retinal Degeneration;Retinitis Pigmentosa;Rhodopsin;Risk;RNA;RNA Interference;RNA Stability;Rodent Model;single molecule;Site;small hairpin RNA;Specificity;Speed;stem;Structure;success;Surface Plasmon Resonance;Synthesis Chemistry;synthetic nucleotide;Testing;Therapeutic;Therapeutic Agents;therapeutic candidate;therapeutic evaluation;therapeutic gene;therapeutic RNA;Titrations;Toxic effect;trafficking;transcriptome sequencing;Transduction Gene;Transgenic Mice;Translating;vector;Work

PROJECT_TITLE: Optimizing Enhanced Hammerhead Ribozymes for Retinal Nucleic Acid Therapeutics

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-NV-P(81)S]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Eye Disease and Disorders of Vision;Macular Degeneration;Neurodegenerative;Neurosciences

PROJECT_TERMS: Address;Affinity;Age related macular degeneration;Aging;aging related disease;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease patient;Amyloid beta-Protein;Atrophic;Basal lamina;Binding;Binding Proteins;Biological Assay;biophysical techniques;Blindness;Blood;Blood capillaries;Bone remodeling;Brain;Bruch's basal membrane structure;calcification;calcification inhibitor;calcium phosphate;California;Cell Adhesion;Cell model;cell motility;Cell Nucleus;Cells;Chemicals;Choroid;complex biological systems;Data;Deposition;Development;Disease;disease model;Disease Progression;Drusen;experimental study;extracellular;Extracellular Matrix;Eye;Fluorescence;Glycoproteins;Goals;Hemostatic function;Hydroxyapatites;Hydroxylation;In Vitro;Investigation;Length;Link;Lipids;Medical;mineralization;Minerals;Modeling;Molecular;Molecular Structure;Natural Immunity;Neurons;NMR Spectroscopy;novel diagnostics;novel therapeutics;Nuclear Magnetic Resonance;Pathologic;Process;Property;Proteins;reconstitution;Resolution;Retina;Risk Factors;Role;Sampling;Senile Plaques;sensor;small molecule;Solid;solid state nuclear magnetic resonance;Specificity;Structure;Structure of retinal pigment epithelium;Surface;tau Proteins;Testing;Therapeutic Agents;Tissues;trait;Universities;Variant;Vitronectin

PROJECT_TITLE: Project 1 - Molecular structure and function


ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: Project Narrative Cognition is the focus of human achievement and is essential for human success, but it is also the focal point of the most malicious attacks on health, giving rise to immense suffering and a high emotional and monetary cost in our society. Treating and preventing neurological and psychiatric disease, as well as the cognitive decline of aging, depends on understanding the cognitive problems presented in the clinic, which in turn depends on understanding the brain bases of these problems. The Training Program in the Neuroscience of Human Cognition is primed to contribute to these endeavors by delivering a steady infusion of young scientists with the high-quality training and the necessary experiences and guidance to prepare them to become scientific leaders and valuable contributors to this agenda.

PI_NAMEs: BRAGA, RODRIGO M;ZELANO, CHRISTINA MARIA (contact)


ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Pain is the principal reason for seeking medical attention, respects no boundaries, is not restricted to any one disease or medical discipline, is distributed across the life span, and experienced by all irrespective of status (economic, educational, etc.) age or gender, and remains difficult to manage if it can be managed at all. Novel and more effective treatments for pain that are so desperately needed will only be discovered by the hard work of the next generation of pain scientists. Thus, this training program fills a compelling need by enhancing and broadening the training of the next generation of pain researchers.

PI_NAMEs: GOLD, MICHAEL S (contact)

PROJECT_TERMS: Clinical;Pain;Training

PROJECT_TITLE: Training in Mechanisms and Clinical Presentation of Pain


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: Public Health Relevance. Mucosal tissues are densely colonized with microbes increasingly shown to confer both protective and harmful effects throughout the body. Much of the focus on microbial commensals has addressed the role of bacterial microbes, yet the systemic effects of fungal colonization have been poorly defined and will be the focus of this new R01 grant.

PI_NAMEs: BENNETT, RICHARD JOHN;WAY, SING SING  (contact)

PROGRAM_OFFICER_NAME: HUDSPETH, KELLY

PROJECT_TERMS: Address;Antibiotics;Antigens;Architecture;Automobile Driving;Bacteria;beta-Glucans;Blood Circulation;Candida albicans;CD4 Positive T Lymphocytes;Cell Communication;Cell Wall;Cells;cellular engineering;Cellular Immunology;Clinical;commensal bacteria;commensal microbes;Communicable Diseases;Data;Defect;dysbiosis;Engineering;Epithelial Cells;Eukaryota;experimental study;extracellular;fungus;gastrointestinal;Gastrointestinal tract structure;Genes;Grant;gut colonization;gut dysbiosis;Health Promotion;host-microbe interactions;Human;IL17 gene;Immune;Immune response;Immunity;Immunocompetent;Immunocompromised Host;immunodeficiency;immunogenic;Immunologic Stimulation;Immunologics;Individual;Infection;Inflammation;Inflammatory Bowel Diseases;intestinal epithelium;Intestines;Intravenous;Investigation;Job's Syndrome;Knowledge;Laboratories;lens;Leukocytes;Life;Ligands;Mannans;Microbe;microbial;Modeling;Molecular;Morphology;mouse model;Mucous Membrane;Mus;mutant;Mycoses;Neutropenia;neutrophil;Oxidases;pathobiont;pathogen;Pathogenesis;pathogenic bacteria;Pattern Recognition;Pattern recognition receptor;Population;Predisposition;Production;Property;public health relevance;Publishing;Reactive Oxygen Species;Recombinants;reconstitution;Research Personnel;response;Risk Factors;Role;Signal Transduction;Specificity;Staphylococcus aureus;STAT3 gene;Structure;Symbiosis;Systemic infection;T-Lymphocyte;Taxonomy;The science of Mycology;Tissues;Toxin;trait;Variant;Virulence;Work;Yeasts

PROJECT_TITLE: Commensal Candida albicans primed Th17 immunity

STUDY_SECTION: IHD

STUDY_SECTION_NAME: Immunity and Host Defense Study Section[IHD]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Dementia;Eye Disease and Disorders of Vision;Macular Degeneration;Neurodegenerative;Neurosciences

PI_NAMEs: THOMPSON, RICHARD BLAIR (contact)

PROJECT_TERMS: advanced disease;Age related macular degeneration;Age related pathologies;aging population;aging related disease;Alzheimer's Disease;Alzheimer's disease brain;Animal Disease Models;Animal Model;animal tissue;Animals;arterial calcification of infancy;Atherosclerosis;Baltimore;Binding;Bioluminescence;Biosensor;Brain;Bruch's basal membrane structure;calcification;Calcium;carbonate dehydratase;Cells;Chemicals;Clinical;cohort;Complex;Deposition;design;Detection;Development;Disease;Drusen;early detection biomarkers;Early Diagnosis;Early identification;Energy Transfer;Exhibits;experimental study;Eye;Family;Fluorescence;Fluorescence Anisotropy;fluorescence imaging;fluorophore;Goals;Heart Valve Diseases;Hemopexin;high throughput screening;Histology;Hydroxyapatites;Image;Immobilization;Immunity;improved;In Vitro;in vivo;Ions;Kinetics;Label;Light;Lipids;Magnetic Resonance Imaging;Malignant Breast Neoplasm;Maryland;Metals;Microscopic;millimeter;Minerals;Modeling;Molecular;molecular imaging;Monitor;multi-photon;Neurons;nonhuman primate;novel;novel therapeutic intervention;Optics;Organelles;Pathologic;Penetration;Perfusion;Phase;Phenotype;Play;Positron-Emission Tomography;Probability;Process;programs;Protein Family;protein function;protein structure;Proteins;Pseudoxanthoma Elasticum;Reporting;Research;Resolution;response;Retina;Role;sensor;sensor technology;Signal Transduction;small molecule;Solid;Specificity;Stains;Structure of retinal pigment epithelium;tau-1;Techniques;Testing;therapeutic target;Time;Tissues;tool;Universities;Vitronectin;X-Ray Computed Tomography

PROJECT_TITLE: Project 2 - Molecular Imaging of ectopic calcification


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Epilepsy;Mental Health;Neurodegenerative;Neurosciences

ORG_CITY: Nashville

ORG_DEPT: SURGERY

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: PROJECT NARRATIVE Temporal lobe epilepsy is the most common form of epilepsy in adults, causes widespread brain network dysfunction, and has widespread effects that are not understood, such as loss of consciousness and cognitive deficits. This study will use functional magnetic resonance imaging and electrophysiological brain recordings in persons with temporal lobe epilepsy to better characterize brain networks contributing to loss of consciousness and cognitive deficits. Through this work we hope to improve understanding of disrupted brain networks in temporal lobe epilepsy and identify potential targets for new therapies that may benefit the lives of those with this devastating disease.

PI_NAMEs: DOSS, DEREK J (contact)

PROGRAM_OFFICER_NAME: MATTHEWS, MARGUERITE

PROJECT_TERMS: Academic Medical Centers;Activities of Daily Living;Acute;Address;Adult;Affect;Anatomy;Area;Arousal;atmospheric sciences;Awareness;Brain;Brain Diseases;Brain region;Chronic;Cognitive;Cognitive deficits;comparison control;Conscious;Data;Disabling;Disease;Distant;Electroencephalography;Electrophysiology (science);Engineering;Environment;Epilepsy;executive function;Fellowship;Focal Seizure;Frequencies;Functional disorder;Functional Magnetic Resonance Imaging;functional magnetic resonance imaging/electroencephalography;Goals;Image;Impairment;improved;Knowledge;Lead;Link;medial temporal lobe;Mediating;Memory;Mentors;Modality;multimodality;Nature;Neocortex;neocortical;Nervous System Disorder;network dysfunction;Neurocognitive;Neurocognitive Deficit;neurocognitive test;neuroregulation;new therapeutic target;Operative Surgical Procedures;Partial Epilepsies;Pathology;Patients;Persons;Population;postoperative recovery;processing speed;Quality of life;Recurrence;Regional Anatomy;Research Training;Rest;Scalp structure;scientific atmosphere;Seizures;Structure;sustained attention;Temporal Lobe Epilepsy;Unconscious State;vigilance;Work

PROJECT_TITLE: Dynamic multimodal connectivity analysis of brain networks in focal epilepsy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F01A-V(20)]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Diabetes;Eye Disease and Disorders of Vision;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Prevention;Social Determinants of Health

PHR: PROJECT NARRATIVE Diabetic retinopathy (DR) is a leading cause for vision loss and remains a major public health problem due to its continued rise in prevalence despite available medical treatments. Barriers in social determinants of health (SDoH) can lead to inadvertent lapses in DR care, which are major preventable risk factors for poor visual outcomes. This project will use novel data science approaches to investigate the SDoH that impact DR care and lay the groundwork for developing interventions to prevent vision loss from DR.

PI_NAMEs: CAI, CINDY XINJI (contact)

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: Address;Adherence;Adult;Affect;Age;American;Appointment;barrier to care;Bayesian Modeling;Biometry;Blindness;career development;Caring;Censuses;Community Surveys;cost;daily functioning;Data Science;design;diabetes management;Diabetes Mellitus;diabetic;Diabetic Retinopathy;Early Diagnosis;Economics;Education;Educational workshop;effective intervention;effective therapy;experience;follow-up;food environment;food insecurity;food security;Future;Goals;Grant;Health;health care availability;health disparity;health equity promotion;Health Food;health inequalities;Health Sciences;Health Status;Healthcare;Healthcare Systems;high risk;high risk population;Housing;Improve Access;improved;improved outcome;Income;Individual;Informatics;innovation;Intervention;K-Series Research Career Programs;Knowledge;Link;low socioeconomic status;Master of Science;Measures;Mediating;Mediation;Mediator;Medical;Medicine;Mentors;Methodology;multidisciplinary;Neighborhoods;novel;Occupations;ophthalmic examination;Outcome;Pathway interactions;Patients;Persons;Physical environment;Play;Population;Populations at Risk;Prevalence;prevent;Public Health;public health intervention;Quality of life;Recommendation;Research;Research Project Grants;Research Proposals;Risk Factors;Role;Scientist;Shapes;skills;social;social health determinants;Societies;Socioeconomic Status;structural health determinants;Techniques;Testing;therapy design;Training;Transportation;tv watching;United States National Institutes of Health;Visual;Visual impairment;voucher;Vulnerable Populations;Work

PROJECT_TITLE: Impact of Social Determinants of Health in Diabetic Retinopathy


NIH_SPENDING_CATS: Hematology

PHR: PROJECT NARRATIVE This is a competitive renewal application for years 46-50 of a T32 program to train postdoctoral investigators in basic and translational benign hematology research. Our program’s primary goal is to develop future academic and scientific leaders in benign hematology research by training promising MD, PhD (or other similar degree) postdoctoral scientists to become independent laboratory-based and translational investigators focused on clinically relevant non-malignant hematology research topics. Highly qualified applicants will undergo comprehensive interdisciplinary research training and career development that prepares them well for sustained, impactful independent research careers.

PI_NAMEs: KEY, NIGEL S. (contact)

PROGRAM_OFFICER_NAME: HILL-PRYOR, CRYSTAL DARLEANE-ROBIN

PROJECT_TERMS: Hematology;Research Training

PROJECT_TITLE: Research Training in Hematology at UNC Chapel Hill

STUDY_SECTION: NITM

STUDY_SECTION_NAME: NHLBI Institutional Training Mechanism Study Section[NITM(OA)]


ORG_CITY: BIRMINGHAM

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: NARRATIVE The rapid advances in biomedical sciences in the past 30 years has resulted in a critical need for well-trained investigators who also have direct involvement with clinical medicine to translate new discoveries in biomedical sciences into workable clinical applications. Medical Scientist Training Programs, such as the one at UAB, that train the most outstanding individuals in both modern medicine and the special intellectual perspective and technical know-how of basic biomedical science is a key component for meeting this need.

PI_NAMEs: YACOUBIAN, TALENE ALENE (contact)

PROGRAM_OFFICER_NAME: NELSON, SHAKIRA M

PROJECT_TERMS: Medical;Scientist;Training Programs

PROJECT_TITLE: Medical Scientist Training Program


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Eye Disease and Disorders of Vision;Macular Degeneration;Neurodegenerative;Neurosciences

PI_NAMEs: LENGYEL, IMRE  (contact)

PROJECT_TERMS: 3-Dimensional;Affect;Age related macular degeneration;aging related disease;Alzheimer's Disease;Apical;Authorization documentation;Autopsy;Back;Basal Cell;Basic Science;Binding Proteins;Biological Models;Blindness;Blood Circulation;Bruch's basal membrane structure;Cadaver;calcification;calcification inhibitor;Calcium;calcium phosphate;Cell Culture System;Cell Culture Techniques;Cell model;Cells;Choroid;Clinical Sciences;Collection;college;Complex;Confocal Microscopy;Culture Media;Data;Dependovirus;Deposition;Development;Devices;Diphosphates;Disease;Disease Progression;Electron Microscopy;end stage disease;Endothelium;Ethics;experimental study;extracellular;Eye;Fluorescence;Foundations;Genes;genetic makeup;Growth;Human;human subject;human tissue;Hydroxyapatites;improved;In Vitro;in vivo;inorganic phosphate;Intervention;Laboratories;laser capture microdissection;Lead;Learning;Lesion;Link;Lipids;London;macromolecule;Maps;materials science;Methods;Microfluidic Microchips;Microfluidics;microvesicles;mineralization;Minerals;Modeling;Molecular;Monitor;multiple omics;Nutrient;Ophthalmology;overexpression;Pathway interactions;Patients;Play;Positioning Attribute;Primary Cell Cultures;Process;Proteins;repository;Role;Sampling;Serum;single cell sequencing;Structure of retinal pigment epithelium;Techniques;three dimensional cell culture;three-dimensional modeling;Tissues;Transfection;treatment strategy;Universities;uptake;Validation;vector;Visualization

PROJECT_TITLE: Project 3 - Mechanisms of extra- and intra-cellular calcification


NIH_SPENDING_CATS: Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Infectious Diseases;Malaria;Neurosciences;Orphan Drug;Patient Safety;Pediatric;Rare Diseases;Vector-Borne Diseases

ORG_CITY: WASHINGTON

ORG_NAME: CHILDREN'S RESEARCH INSTITUTE

ORG_STATE: DC

PHR: Project Narrative To date, there are no adjunctive therapies to reduce pediatric cerebral malaria mortality or morbidity, resulting in enormous economic and public health impacts. This research aims to evaluate the safety and preliminary efficacy of a candidate adjunctive therapy for pediatric cerebral malaria, 6-diazo-5-oxo-L-norleucine (DON). If found safe now, and if future clinical trials confirm clinical efficacy, this paradigm-shifting intervention could be easily implemented by trained medical staff and readily scaled up to impact public health across malaria- endemic countries.

PI_NAMEs: POSTELS, DOUGLAS  (contact)

PROGRAM_OFFICER_NAME: MCGUGAN, GLEN C

PROJECT_TERMS: 5 year old;Adult;Adverse event;Affect;Africa South of the Sahara;African;Animal Model;Animals;antagonist;Anti-malarials;Antineoplastic Agents;Area;Biological Markers;Blood - brain barrier anatomy;Brain Edema;brain magnetic resonance imaging;brain volume;candidate marker;Cephalic;Cerebral Malaria;Cerebrovascular Circulation;Cessation of life;Child;Childhood;Clinical;clinical efficacy;Clinical Trials;Coma;Communicable Diseases;Country;Data;Death Rate;Diagnosis;disability;Disease;Dose;Double-Blind Method;drug discovery;Drug Kinetics;Economics;efficacy study;Electroencephalography;Enrollment;Evaluation;experience;Future;Glutamine;Goals;Histopathology;Hospitals;Human;improved;improved outcome;Infection;Intervention;Intravenous;Magnetic Resonance Imaging;Malaria;malaria infection;Medical Staff;Morbidity - disease rate;mortality;mouse model;Mouse Strains;Mus;Neurologic;Norleucine;Outcome;Parasitemia;Participant;Pathologic;patient population;Patients;Pediatric cohort;Persons;Phase;Physiological;Placebo Control;Placebos;Plasmodium berghei;Plasmodium falciparum;Population;preclinical study;Predisposition;primary outcome;Process;Public Health;Publishing;radiological imaging;Randomized;Research;Risk Factors;Safety;safety study;scale up;Serious Adverse Event;Supportive care;Survivors;Syndrome;Target Populations;Testing;Therapeutic Intervention;Time;Toxic effect;Training;tumor;Vulnerable Populations

PROJECT_TITLE: DON in Pediatric Cerebral Malaria: A Phase I / II Dose-Escalation Safety Study


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

ORG_STATE: PA

PI_NAMEs: RADOMSKI, THOMAS  (contact);RUBIO, DORIS M

PROGRAM_OFFICER_NAME: HARTSHORN, CHRISTOPHER

PROJECT_TERMS: Adopted;Applications Grants;Award;career;career development;Career Mobility;Clinical Sciences;Clinical Trials;Collaborations;commercialization;Communities;Competence;Complement;Credentialing;Data;data management;Degree program;design;Development;Doctor of Philosophy;editorial;educational atmosphere;Educational process of instructing;Engineering;Ensure;Entrepreneurship;Ethics;Evaluation;experience;Exposure to;Faculty;faculty mentor;Feedback;Fellowship;Fellowship Program;flexibility;Foundations;Future;Goals;Growth;Health Sciences;Individual;Infrastructure;innovation;Interdisciplinary Study;investigator training;Investments;K-Series Research Career Programs;Leadership;Learning;learning community;Life;Mentors;Methodology;Minority-Serving Institution;Modeling;Monitor;multidisciplinary;National Research Service Awards;novel;peer coaching;Phase;Population;Positioning Attribute;Postdoctoral Fellow;pre-doctoral;prevent;Process;Productivity;Professional Competence;programs;Qualitative Research;recruit;Research;research and development;Research Methodology;Research Personnel;Research Project Grants;research study;resilience;Resources;satisfaction;Schedule;Schools;Science;self-directed learning;skills;skills training;Social Work;Students;success;Time;TNFSF15 gene;Training;Training Activity;Training and Education;Training Programs;translational pipeline;Translational Research;Translations;Universities;Woman;Work

PROJECT_TITLE: J. NRSA Training Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cardiovascular;Dementia;Dental, Oral, and Craniofacial Disease;Eye Disease and Disorders of Vision;Heart Disease;Heart Disease - Coronary Heart Disease;Macular Degeneration;Neurodegenerative;Neurosciences;Prevention;Rare Diseases

PI_NAMEs: MILLAN, JOSE LUIS  (contact)

PROJECT_TERMS: Address;Affect;Age related macular degeneration;aging related disease;Alkaline Phosphatase;Alzheimer's Disease;Ameloblasts;Area;arterial calcification of infancy;Arteries;Atherosclerosis;Biochemical Process;Blood Vessels;bone;Bone Diseases;Brain;Bruch's basal membrane structure;Bulla;calcification;calcification inhibitor;Cell Physiology;Cells;Characteristics;Chondrocytes;Choroid;Clinical;Data;Dental;Deposition;design;Diphosphates;Disease;druggable target;Drusen;Dysplasia;Endothelium;extracellular;Extracellular Matrix;extracellular vesicles;Eye;Functional disorder;Genes;genetic manipulation;Goals;Human;Hydroxyapatites;Hypophosphatasia;in vivo;Inflammation;inorganic phosphate;Inorganic Phosphate Transporter;insight;Lead;macula;Medial;Mediating;Medical;mineralization;Minerals;Modeling;Molecular;mouse model;multidisciplinary;Mus;Mutation;normal aging;novel;Odontoblasts;Osteoblasts;Osteomalacia;Pathologic;Pathway interactions;pharmacologic;Phosphorylcholine;Physiological;prevent;Prevention;Production;promoter;Pseudoxanthoma Elasticum;pyrophosphatase;Rickets;Risk Factors;Role;skeletal;Structure of retinal pigment epithelium;synergism;Testing;Tissues;Tooth structure;Up-Regulation;Vascular calcification;Vesicle

PROJECT_TITLE: Project 4 - Mechanisms of pyrophosphate dysregulation


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Mental Health;Neurosciences;Opioids;Substance Misuse

ORG_DEPT: PHARMACOLOGY

PHR: Project Narrative Substance use disorders are a major public health issue and are characterized by maladaptive learning processes resulting in overvaluation of drugs and drug-associated stimuli, as well as disruptions in non-drug reward reinforcement learning. Though upregulated kappa opioid receptor activity is thought to be implicated in maladaptive negative reinforcement processes underlying addiction, the role of both endogenous and augmented activity of the kappa opioid receptor system in learning has not been thoroughly investigated. The focus of this proposal is to directly assess predictions of this model by determining the endogenous role of kappa opioid receptor signaling in adaptive reinforcement learning and whether upregulation of the system is sufficient to drive maladaptive learning behaviors.

PI_NAMEs: FARAHBAKHSH, ZAHRA  (contact)

PROGRAM_OFFICER_NAME: FALCON-MORALES, EDGARDO

PROJECT_TERMS: Abstinence;adaptive learning;addiction;Address;Agonist;Alcohol consumption;antagonist;Automobile Driving;Behavior;Behavioral;Bilateral;Cells;Chronic;Cues;Data;Data Set;Dependence;Development;discrete time;drug reward;Dynorphins;dysphoria;Elements;Etiology;Event;experimental study;Female;Fiber;Goals;High Prevalence;in vivo;in vivo optical imaging;Intake;Internal Ribosome Entry Site;Investigation;kappa opioid receptors;learned behavior;Learning;Ligands;male;Measurement;Measures;Mediating;Modeling;motivated behavior;Mus;negative affect;Negative Reinforcements;Neurobiology;Neurosciences;non-drug;norbinaltorphimine;novel;Nucleus Accumbens;Operant Conditioning;Opioid Antagonist;optogenetics;Pattern;Pharmaceutical Preparations;pharmacologic;Pharmacological Treatment;Phenotype;Photometry;Play;Positive Reinforcements;predictive modeling;prevent;Process;Psychological reinforcement;Public Health;receptor function;receptor sensitivity;Receptor Signaling;reinforcer;Research;Resolution;response;Rewards;Role;self-directed learning;sensor;Signal Transduction;Stimulus;Stress;substance use;Substance Use Disorder;System;Testing;Time;Training;Up-Regulation;Viral Vector

PROJECT_TITLE: Role of the kappa opioid receptor system in learning and substance use disorders


ADMINISTERING_IC: AA

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

ORG_CITY: SEATTLE

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: PROJECT NARRATIVE Racial disparities in alcohol use behaviors and outcomes are a significant public health concern in the United States, particularly among historically marginalized populations. This research will use an innovative mixed- methods approach to examine the relationship between neighborhood characteristics (e.g., neighborhood disorganization and deprivation), and the role of drinking motives, on alcohol consumption and alcohol-related consequences among Black adults. Findings may encourage health researchers and professionals to address community-related barriers maintaining alcohol use-related inequities and enable the development of pertinent, culturally sensitive, community-driven interventions and policies to eliminate such disparities.

PI_NAMEs: MACKEY, CHELSEA DENISE (contact)

PROGRAM_OFFICER_NAME: RUFFIN, BEVERLY

PROJECT_TERMS: Address;Adult;Advocate;Affect;Alcohol abuse;alcohol consequences;Alcohol consumption;alcohol misuse;alcohol outlet density;alcohol related consequences;alcohol use disorder;Alcohols;Attention;Behavior;Black American;Black Populations;Black race;burden of illness;Characteristics;Clinical;clinical practice;Communities;community led intervention;community-level factor;coping;Cross-Sectional Studies;Data;Data Collection;density;deprivation;Development;Disadvantaged;Disease;Disparity;distilled alcoholic beverage;drinking;efficacious intervention;Environment;Environmental Impact;ethnic minority;Etiology;experience;Future;Goals;Health;health determinants;Health Disparities Research;health disparity;health equity;health inequalities;Home;Individual;Inequity;innovation;interdisciplinary approach;Intervention;Interview;Investigation;Knowledge;Link;Literature;marginalized population;Methodology;Methods;Minority Groups;Modeling;Motivation;National Institute on Alcohol Abuse and Alcoholism;neighborhood disadvantage;Neighborhoods;novel strategies;Outcome;Participant;Pathway interactions;Persons;Phase;phenomenological models;Policies;policy implication;Policy Maker;Prevention;Prevention strategy;protective factors;psychological distress;psychosocial stressors;Public Health;racial disparity;racial health disparity;racial minority;Recommendation;Research;research data dissemination;Research Personnel;Risk;Risk Factors;Role;Sampling;Scientist;skills;social;Social Disorganizations;social stressor;Strategic Planning;Structure;substance use;Symptoms;Techniques;theories;Training;United States;United States National Institutes of Health;Work;Writing;young adult

PROJECT_TITLE: Hitting Close to Home: A Multi-Method Investigation of Neighborhood Characteristics and Drinking Motives on Alcohol-Related Health Disparities


NIH_SPENDING_CATS: Chronic Obstructive Pulmonary Disease;Complementary and Integrative Health;Infectious Diseases;Lung;Natural Products;Nutrition;Prevention;Regenerative Medicine

ORG_CITY: PHILADELPHIA

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

PHR: PROJECT NARRATIVE Conductive airway epithelium in patients with chronic obstructive pulmonary disease often show pathologic changes and this will have profound effect on the outcome of respiratory infections. We will determine the mechanisms underlying the defective airway repair in stem cells present in the COPD airways. We will also examine whether quercetin, a natural polyphenol can reverse the pathologic changes of airway epithelium in mice and COPD subjects.

PI_NAMEs: SAJJAN, UMADEVI SIVANAPPA (contact)

PROGRAM_OFFICER_NAME: LU, QING

PROJECT_TERMS: Acceleration;adaptive immune response;adaptive immunity;Affect;Airway Disease;airway epithelium;airway immune response;airway regeneration;airway remodeling;airway repair;Anti-Inflammatory Agents;Antioxidants;Basal Cell;Basal Cell Hyperplasia;bronchial epithelium;CDH1 gene;Cell Cycle;Cell Differentiation process;Cell Proliferation;Cells;chemokine;Chronic Obstructive Pulmonary Disease;Consumption;Cultured Cells;cytokine;Data;Development;Diet;disease phenotype;Epithelial Cells;epithelial repair;Epithelium;epithelium regeneration;Functional Regeneration;Genes;Goblet Cells;Health Benefit;Homeobox Genes;Homeostasis;HOX protein;Human;Immune response;improved;Infection;Injury;Innate Immune Response;insight;knock-down;Knockout Mice;Lung;Lung Diseases;lung health;Maintenance;Metaplasia;Molecular;Morphogenesis;mouse model;Mus;Natural Immunity;Natural regeneration;non-smoker;novel;Outcome;Pathologic;Pathway interactions;Patients;Placebos;Play;polarized cell;polyphenol;prevent;programs;Property;Publishing;pulmonary function;Pulmonary Inflammation;Quercetin;Regenerative pathway;Regulation;repaired;Repression;Research;Respiratory Tract Infections;response;Rhinovirus;Rhinovirus infection;Role;Signal Transduction;Site;Squamous Cell;STC2 gene;stem cells;Testing;Tissues;transcriptional reprogramming;transcriptomics

PROJECT_TITLE: Quercetin prevent airway epithelial remodeling and promote lung health in OPD

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Pediatric;Substance Misuse

PHR: PROJECT NARRATIVE This is the first prospective, longitudinal study to examine intergenerational patterns of service use in high-risk families. I will investigate how parents’ own experiences with substance use disorders and services affect their decision to seek services for their children. Findings will provide the empirical basis to reduce inequities in service use for high-risk children and their families.

PI_NAMEs: LUNA, MARÍA JOSÉ (contact)

PROGRAM_OFFICER_NAME: LYNCH, SEAN EDWARD WINTERS

PROJECT_TERMS: addiction;Address;Adolescence;Adolescent;Adult;Affect;Age;aged;Alcohol consumption;antisocial behavior;Anxiety Disorders;Attitude;Behavior;Black race;Characteristics;Child;child services;Clinical;Communities;comorbidity;Data;Data Collection;Disease;Drug usage;Ethnic Origin;experience;Face;Family;Fellowship;Female;follow-up;Funding;Future;General Population;health inequalities;health service use;Health Services Research;high risk;Human Resources;Imprisonment;improved;improved outcome;Inequity;Inpatients;interest;intergenerational;Interview;Justice;juvenile justice system;Latinx;Location;longitudinal, prospective study;male;marijuana use;Mental disorders;Mental Health;Mental Health Services;Mentorship;Mood Disorders;National Institute of Drug Abuse;next generation;Not Hispanic or Latino;novel strategies;Outcome;Outpatients;Parents;Participant;Pattern;Post-Traumatic Stress Disorders;Principal Investigator;Psychopathology;Race;Recording of previous events;Research;Research Personnel;Risk;Sampling;Schools;Science;Service setting;service utilization;Services;sex;Strategic Planning;substance use;Substance Use Disorder;System;Training;transmission process;United States;Youth

PROJECT_TITLE: How Do Parents' Experiences with Services Influence Their Children's Service Use? A Longitudinal, Intergenerational Study of High-Risk Families

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F16-L(20)L]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Heart Disease

ORG_CITY: CORAL GABLES

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: Atrial fibrillation (AF) is the most common heart rhythm disorder and a major cause of stroke. Unfortunately, current therapies for AF are suboptimal, in part because the precise electrical ‘sources’ of AF within the heart are difficult to find. This project uses a unique new method, called Electrogram Morphology Recurrence, to: a) find these electrical sources of AF and b) target these electrical sources, using either ablation or a gene therapy approach.

PI_NAMEs: GOLDBERGER, JEFFREY J (contact)

PROGRAM_OFFICER_NAME: TINSLEY, EMILY

PROJECT_TERMS: Ablation;Address;Adipose tissue;Affect;Age;American;Anatomy;Area;Arrhythmia;Atrial Fibrillation;autonomic nerve;Autonomic nervous system;canine model;Canis familiaris;Cardiac ablation;catalase;Clinical;Clinical Research;Collaborations;Complex;Control Animal;curative treatments;Development;Diagnostic Procedure;Disease;Electrocardiogram;Electrophysiology (science);Fibrosis;Freedom;Frequencies;Functional disorder;gene therapy;Genes;Goals;Heart;Heart Atrium;heart rhythm;improved;Incidence;Individual;Injections;Laboratories;Left;Length;Lesion;Libraries;Location;Maintenance;Maps;Measures;Methods;Mitochondria;Modeling;Molecular;Morphology;Nerve;nerve supply;novel;novel diagnostics;Outcome;oxidative damage;Patients;Pattern;Peptides;Physiological;Plasmids;Play;Population;prevent;Property;Pulmonary veins;Randomized;recruit;Recurrence;Resolution;Rest;Right atrial structure;Role;Science;Signal Transduction;Sinus;Site;small hairpin RNA;Source;Stroke;success;Techniques;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;Time;tool;Validation

PROJECT_TITLE: Pathophysiological Significance of Atrial Fibrillation Electrogram Patterns


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Genetics;Human Genome;Mental Health;Mental Illness;Neurosciences;Post-Traumatic Stress Disorder (PTSD);Precision Medicine;Prevention

ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: PROJECT NARRATIVE Posttraumatic stress disorder (PTSD) is an underdiagnosed and undertreated disorder affecting 1 in 4 US individuals in a given year. Early detection and treatment are crucial for positive outcomes, yet despite its high heritability, genetic risk estimation for PTSD remains largely imprecise. This proposal aims to improve detection of PTSD-relevant signatures by integrating interrogation of genetic risk with nuanced measures of environmental trauma and stress to elucidate context-dependent genetic and traumatic regulation of disorder susceptibility, carrying the translational potential to better predict and mitigate complex PTSD risk.

PI_NAMEs: SEAH, CARINA  (contact)

PROGRAM_OFFICER_NAME: SABBAGH, JONATHAN JACOB

PROJECT_TERMS: accurate diagnostics;Advocacy;Affect;algorithm development;Amygdaloid structure;Area;Autopsy;biobank;biological adaptation to stress;Biology;biomarker discovery;Blood;Brain;brain cell;Brain region;brain tissue;care delivery;Catalogs;cell type;clinical practice;Clinical Research;clinical risk;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;Cognitive;cohort;Complex;computing resources;conditioned fear;Core Facility;CRISPR screen;Data;Detection;Development;Diagnosis;Disease;disorder risk;Distal;Early Diagnosis;Early Intervention;Early treatment;Electronic Health Record;Elements;Environment;Environmental Exposure;Environmental Risk Factor;Etiology;Expanded CRISPR-compatible cellular indexing of transcriptomes and epitopes by sequencing;experimental study;Exposure to;Fellowship;Functional disorder;Future;gene environment interaction;Gene Expression;gene interaction;Gene Targeting;Genes;Genetic;genetic element;Genetic Risk;Genetic Transcription;genetic variant;genome wide association study;genome-wide;genomic locus;Genomics;Genotype;Glossary;Goals;Heritability;Human;Hydrocortisone;improved;In Vitro;in vitro Model;Individual;Institution;Joints;Leadership;Link;Maps;Measures;Medial;Mediating;medical schools;Mentorship;Methods;Modeling;Nature;Neurons;Neurosciences;novel;Outcome;outcome prediction;Pathway interactions;Patient risk;patient stratification;Patients;Pattern;pediatric trauma;personalized medicine;phenome;Phenotype;Physicians;physiologic model;Post-Traumatic Stress Disorders;Predisposition;Prefrontal Cortex;programs;Quantitative Trait Loci;Regulation;Research;resilience;Resources;Risk;Risk Estimate;risk prediction;risk stratification;risk variant;Role;Sampling;Scholarship;scientific computing;Scientist;Single Nucleotide Polymorphism;single-cell RNA sequencing;statistics;Stratification;Stress;theories;Training;Training Support;transcriptomics;Translating;translational impact;translational potential;Trauma;trauma exposure;Traumatic Brain Injury;traumatic event;Universities;Untranslated RNA;Validation;Variant;variant detection;Visual;Work

PROJECT_TITLE: Modeling gene x environment interactions in post-traumatic stress disorder.


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Prevention

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE Recent advances in magnetic resonance imaging and facial recognition technologies have together made it possible to create realistic images of participant faces from medical research images and automatically match these with photographs on a large scale, creating an imminent and growing threat to the privacy of research participants, including those in many large imaging studies of Alzheimer's Disease (AD) and related dementias. We propose a novel technique that de-identifies MRI by replacing facial imagery with an average face, producing a de-identified MRI that resembles an unmodified image and has reduced negative effects upon popular brain biomarker measurement software. We propose to develop/refine, extend, validate, and publicly share our technique to protect the privacy of research participants and promote wider, safer sharing of research imaging data.

PI_NAMEs: SCHWARZ, CHRISTOPHER GEORGE (contact)

PROGRAM_OFFICER_NAME: HSIAO, JOHN

PROJECT_TERMS: Address;Administrator;Adoption;Age;age effect;Aging;Agreement;Algorithms;Alzheimer's Disease;Alzheimer's disease related dementia;Amyloid;Bioethics;Biological Markers;Brain;Brain imaging;brain magnetic resonance imaging;Clinic;Collaborations;Computer software;Consent;Data;Data Set;data sharing;demographics;Diagnosis;Diffusion;digital;Education;Educational Materials;Event;Face;facial transplantation;Funding;genetic risk factor;Health;Health protection;High Resolution Computed Tomography;Image;Imagery;imaging biomarker;imaging modality;imaging study;improved;Individual;Inferior;Legal;Link;Magnetic Resonance Imaging;Measurement;Measures;Medical Research;Metabolism;Methods;Modality;Modernization;Modification;Names;neuroimaging;neuropsychiatry;next generation;Noise;novel;Participant;Perception;Performance;Perfusion;policy recommendation;Population;Population Heterogeneity;Positron-Emission Tomography;Predisposition;prevent;Privacy;privacy protection;programs;Public Participation;public trust;Publishing;Race;Recommendation;reconstruction;Research;research study;Resolution;Risk;Sampling;Scanning;sex;software development;study population;Subgroup;tau Proteins;Techniques;Technology;Testing;Tracer;Validation;Work;X-Ray Computed Tomography

PROJECT_TITLE: Protecting the Confidentiality of Participants in Studies of Alzheimer's Disease and Related Dementias by Replacing Face Imagery in MRI

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: KNOXVILLE

ORG_NAME: UNIVERSITY OF TENNESSEE KNOXVILLE

PHR: Project Narrative This 5-year program's goal is to support FDA's efforts to improve the training of state, local, territorial and tribal (SLTT) food safety officials, set standards, and administer training and education programs to ensure a competent work force in program areas under its purview by addressing the four key components: 1) National Curriculum Standard (NCS) development; 2) Course Delivery and Planning for Course Offerings and Program Area; 3) Course Design, Development and Evaluation; and 4) Facilitation for Updating and Developing. The project aims will be achieved thorough the following specific deliverables per Project Year, which can be adjusted to meet OTED priorities: 1) Participate in Annual Meeting with OTED; 2) Support 2 instructor led course development/redesign projects with 2 development meetings, 2 walkthroughs, and 2 pilots; 3) Develop or redesign up to 5 web courses; 4) Support up to 14 instructor led course deliveries in Years 1-3, 13 deliveries in Year 4, and 12 deliveries in Year 5 for federal and SLTT regulators; 5) Provide unlimited access to hosted web courses by federal and SLTT regulators; 6) Support NCS development work such as conducting gap analyses of existing course content and resource materials, and development or refinement of curriculum frameworks; 7) Support facilitation of online focus groups or development, administration and analysis of surveys to either evaluate the need for new OTED courses, revise existing courses, change course delivery modalities, or solicit input on OTED business processes; 8) Provide technical support to OTED on 508 compliance and instructional design practices, following the ADDIE framework; 9) Report all course performance and evaluation data to OTED; and 10) Submit required financial and progress reports. Our goal is to serve as a resource for OTED and provide flexibility in our approaches and plan.

PI_NAMEs: THOMPSON, SHARON R (contact)

PROGRAM_OFFICER_NAME: WERNICK, MARC

PROJECT_TITLE: Supporting FDA’s National Curriculum Standard Development and Training Development and Delivery


ORG_CITY: DENVER

ORG_NAME: NATIONAL ENVIRONMENTAL HEALTH ASSOCIATION

PHR: Project Narrative  The public health significance of this cooperative agreement proposal is that a knowledgeable and educated food safety regulatory workforce will help keep unsafe food from entering the food supply. Developing and delivering science-based education and training will help reduce the number of people who are harmed or killed by unsafe food.

PI_NAMEs: BAKER, RANCE  (contact)

PROGRAM_OFFICER_NAME: HOLLOWAY, DEIRDRA

PROJECT_TITLE: NEHA's Building Food Safety Regulatory Capacity Through the Development of the National Curriculum Standard and Through Educational Development, Training and Other Learning Moments


ORG_CITY: DETROIT

ORG_NAME: JOHN D DINGELL VA MEDICAL CENTER

ORG_STATE: MI

PHR: Narrative: Sleep apnea is associated with cardiovascular dysfunction and increased performance fatigability. Thus, the development of novel treatments to eliminate apnea and mitigate associated co-morbidities is imperative. We will address this mandate by determining if repeated exposure to mild intermittent hypoxia (MIH) mitigates cardiovascular dysfunction and performance fatigability. We propose that exposure to MIH has a multipronged effect. MIH directly targets cardiovascular co-morbidities, while simultaneously enhancing upper airway stability and increasing the arousal threshold. These modifications may serve to directly mitigate apnea. Alternatively, these modifications may serve to improve treatment adherence with continuous positive airway pressure. Independent of its effect, MIH may serve as an adjunctive therapy which provides another path to mitigating cardiovascular co-morbidities that might ultimately result in improvements in performance fatigability.

PI_NAMEs: MATEIKA, JASON H. (contact)

PROJECT_TERMS: Acute;Address;Adherence;airway muscle;Apnea;Arousal;Autonomic nervous system;Blood Pressure;blood pressure reduction;Blood Vessels;Cardiovascular Physiology;Cardiovascular system;comorbidity;Continuous Positive Airway Pressure;Coupled;Development;Disease;Equilibrium;Event;Exercise;exercise capacity;Exposure to;Fatigue;fitness;Functional disorder;Funding;Goals;Health;Hemoglobin;Hour;Human;hypertensive;Hypocapnia;Hypoxia;improved;improved outcome;Individual;Innovative Therapy;Link;Measures;Metabolic;Metabolism;Microvascular Dysfunction;military veteran;Modification;Muscle;Myoglobin;Neurocognitive;novel;Obstructive Sleep Apnea;Outcome;Outcome Measure;Oxygen Consumption;Patients;Performance;Perfusion;Peripheral;pressure;Prevalence;primary outcome;respiratory;secondary outcome;Severities;Sleep;Sleep Apnea Syndromes;Stimulus;Therapeutic;Time;treatment adherence;Uncertainty;Vascular resistance

PROJECT_TITLE: Intermittent hypoxia-initiated plasticity in humans: A multi-pronged therapeutic approach to treat sleep apnea and overlapping co-morbidities.


NIH_SPENDING_CATS: Behavioral and Social Science;Biotechnology;Brain Disorders;Cocaine;Drug Abuse (NIDA only);Genetics;Neurosciences;Opioid Misuse and Addiction;Opioids;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: RICHMOND

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: PROJECT NARRATIVE Transcription factors directly bind DNA to regulate the expression of targeted genes within brain cells, a process that is initiated by drug use. While the expression and function of transcription factors is correlated with addiction, the exact causal contribution of these factors in worsening drug use behaviors often remains unclear. Here, we demonstrate the potential of utilizing re-engineered synthetic transcription factors to query the causal contribution of ZFP189 to the drug-specific phenotype to resolve their exact role in drug-specific transcription and behaviors.

PI_NAMEs: PICONE, JOSEPH ANTHONY (contact)

PROGRAM_OFFICER_NAME: BABECKI, BETH

PROJECT_TERMS: addiction;Area;Automobile Driving;awake;Behavior;Behavioral;Behavioral Paradigm;Bilateral;Biological Process;Brain;brain cell;Brain region;brain reward regions;Candidate Disease Gene;causal variant;Cocaine;cocaine related behaviors;cocaine use;Complex;Cyclic AMP-Responsive DNA-Binding Protein;Data;Data Set;design;Development;DNA Binding;Down-Regulation;drug addiction pharmacotherapy;Drug Design;drug of abuse;drug reinforcement;Drug Targeting;Drug usage;drug use behavior;Engineering;Epigenetic Process;Event;experience;experimental study;Fibrinogen;Future;Gene Expression Regulation;Gene Targeting;Genes;Genetic Transcription;Genome;Goals;in vivo;Injections;innovation;Intervention;Intravenous;intravenous drug use;Knowledge;Locomotion;Mediating;Molecular;Morphine;Mus;neuroadaptation;Neurons;next generation;novel;novel strategies;novel therapeutics;Nucleus Accumbens;Opiate Addiction;Opioid;opioid use;Pathogenicity;Pharmaceutical Preparations;pharmacologic;Pharmacotherapy;Phenotype;Procedures;Process;programs;Property;Psychological reinforcement;Publishing;reinforcer;Repression;Research;Research Personnel;response;reward circuitry;Rewards;Rodent;Role;Saline;Self Administration;Signal Transduction;Stimulant;Structure;Substance Use Disorder;success;Synapses;synthetic biology;Techniques;Testing;Tissues;tool;Training;Transcript;transcription factor;Transcription Process;Transcriptional Regulation;transcriptome sequencing;transcriptomic profiling;Up-Regulation;Variant;Viral;Work;Zinc Fingers

PROJECT_TITLE: Designing synthetic transcription factors to study drug-specific transcription and behaviors