NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Depression;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Mental Health;Mental Illness;Pediatric

ORG_CITY: NAIROBI

ORG_COUNTRY: KENYA

ORG_FIPS: KE

ORG_NAME: UNIVERSITY OF NAIROBI

PHR: Narrative The proposed study, led by a collaborative group of researchers from Kenya and the United States is among the first to test the effectiveness of a mental health intervention for multiple common mental health conditions (depressive, anxiety and trauma symptoms) among adolescents and youth with HIV in sub-Saharan Africa. The study will also evaluate key factors for successful intervention implementation and conduct an economic evaluation to inform future intervention scale-up. Addressing mental health among adolescents and youth living with HIV, who are at highest risk of poor HIV outcomes is key to their overall health and survival, and population-level HIV prevention efforts.

PI_NAMEs: COLLINS, PAMELA Y;MATHAI, MUTHONI MUTHONI;WAMALWA, DALTON CHEKOKO (contact)

PROGRAM_OFFICER_NAME: VEDHAM, VIDYA

PROJECT_TERMS: Address;Adolescence;Adolescent;Adoption;Adult;Affect;Africa South of the Sahara;Age;AIDS prevention;antiretroviral therapy;Anxiety;anxiety symptoms;Caring;Clinic;Clinic Visits;Clinical;clinically significant;Cluster randomized trial;Cognitive;Cognitive Therapy;Collaborations;comorbidity;Competence;coping;cost;Data;depressive symptoms;Development;Diagnostic;Disease Progression;economic evaluation;Effectiveness;effectiveness evaluation;effectiveness outcome;effectiveness testing;Elements;follow-up;Frequencies;Funding;Future;Guidelines;Health;Health Personnel;Health Services Accessibility;Health system;high risk;HIV;HIV-infected adolescents;Hybrids;implementation barriers;implementation context;implementation cost;implementation determinants;implementation intervention;implementation measures;implementation outcomes;implementation process;implementation/effectiveness;Improve Access;improved;Income;Individual;innovation;International;Intervention;Kenya;Length;low and middle-income countries;Low income;Maintenance;Mental Depression;Mental disorders;Mental Health;Mental Health Services;mental training;Modeling;Neuropsychology;Outcome;Patients;Persons;Pilot Projects;Policy Maker;Population;Problem Solving;Procedures;Process;Provider;psychoeducation;psychologic;psychological distress;psychological symptom;Psychosocial Assessment and Care;Randomized, Controlled Trials;Recommendation;reduce symptoms;Relaxation;Research;Research Personnel;routine care;satisfaction;scale up;Schools;screening;secondary outcome;Services;skills;Specialist;standard of care;Stretching;successful intervention;Supervision;symptomatology;Symptoms;System;Telephone;Time;Training;Trauma;trauma symptom;Treatment outcome;United States;uptake;Viral;Youth

PROJECT_TITLE: INTEGRATING A TRANSDIAGNOSTIC PSYCHOLOGICAL INTERVENTION IN THE CARE FOR ADOLESCENTS AND YOUTH WITH HIV IN KENYA


ADMINISTERING_IC: DC

ARRA_FUNDED: N

ED_INST_TYPE: UNIVERSITY-WIDE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Aphasia;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Epilepsy;Neurodegenerative;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Stroke

ORG_CITY: WASHINGTON

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: GEORGETOWN UNIVERSITY

ORG_STATE: DC

PHR: PROJECT NARRATIVE Infants have a remarkable ability to successfully acquire language after experiencing early left hemisphere injuries like perinatal stroke and early-onset epilepsy, but how white matter tracts connecting cortical language areas mature in response to these injuries remains unclear. This proposal aims to study white matter connectivity in the language network of typically developing infants who are acquiring language, and in patients with histories of early-onset epilepsy and perinatal stroke. Investigating how connectivity arises in the language network in response to the acquisition of language in typical and clinical populations will provide insight into the fundamental mechanisms of cognitive and brain development and guide future intervention strategies in stroke and epilepsy.

PI_NAMEs: MARCELLE, MADELINE  (contact)

PROGRAM_OFFICER_NAME: SCHURMAN, JACLYN REBECCA

PROJECT_TERMS: Ablation;acute stroke;Adult;Affect;Anisotropy;Aphasia;Area;Behavioral;Birth;Brain;brain behavior;Brain Injuries;Child;Chronic;Clinical;Cognitive;Communication impairment;Complex;Comprehension;connectome;Data;Development;Diffusion Magnetic Resonance Imaging;Disease;Disinhibition;Dorsal;early adolescence;early experience;early onset;Epilepsy;Feedback;frontal lobe;Functional Magnetic Resonance Imaging;Future;Image;Impairment;Infant;Injury;insight;Instruction;Intervention;Language;Language Development;Language Disorders;language impairment;language processing;Learning;Left;Lesion;Life;Linguistics;Link;Literature;Long-Term Effects;Measures;Modeling;myelination;Names;National Institute on Deafness and Other Communication Disorders;neural;Partial Epilepsies;Pathology;Pathway interactions;Patients;Pattern;perinatal stroke;Play;Population;Process;Production;programs;rate of change;Recording of previous events;response;response to injury;Role;Seizures;Speech;Stroke;Structure;Temporal Lobe;trend;verbal;Voice;white matter;white matter change;white matter damage

PROJECT_TITLE: Development of White Matter Language Tracts after Early Life Epilepsy and Stroke


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Attention Deficit Hyperactivity Disorder (ADHD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Prevention;Social Determinants of Health;Telehealth

ORG_CITY: MIAMI

ORG_DEPT: PSYCHOLOGY

ORG_NAME: FLORIDA INTERNATIONAL UNIVERSITY

ORG_STATE: FL

PHR: PROJECT NARRATIVE The current study aims to develop and pilot a behavioral parenting just in time adaptive intervention (JITAI) for children with ADHD and academic difficulties utilizing an existing mHealth application. This study holds substantial public health benefit as it will examine the effectiveness of a low-cost, high reach intervention for ADHD—a highly prevalent and costly mental health disorder. The present study will inform the approach used in a subsequent clinical trial and has the potential to reduce child mental health burden.

PI_NAMEs: MERRILL, BRITTANY MORGAN (contact)

PROGRAM_OFFICER_NAME: PUGLIESE, CARA ELISABETH

PROJECT_TERMS: acceptability and feasibility;adaptive intervention;Aftercare;American;Area;arm;Attention deficit hyperactivity disorder;Attenuated;Behavioral;brief intervention;Businesses;Cellular Phone;Child;Child Behavior;Child Mental Health;Child Rearing;Childhood;Chronic;Clinic;Clinical;Clinical Trials;Communities;Control Groups;cost;Data;Data Collection;design;Drops;Educational Intervention;Effectiveness;effectiveness evaluation;Effectiveness of Interventions;effectiveness trial;Evidence based treatment;experience;Family;Feedback;flexibility;Focus Groups;Guidelines;Health Benefit;Health system;Healthcare Systems;High Prevalence;Home;Human Resources;Impairment;improved;Internet;Intervention;intervention refinement;Interview;Low Income Population;machine learning algorithm;marginalization;Measures;Mental disorders;Mental Health;Mental Health Services;mhealth interventions;Mind;Minority;Mobile Health Application;Occupational;Outcome;Parent-Child Relations;parenting intervention;Parents;Performance;personalized intervention;pilot trial;Prevalence;Protocols documentation;psychosocial;Public Health;Randomized;randomized trial;recruit;Reporting;Research;skills;smartphone application;software development;standard care;Stress;success;Surveys;Technology;Testing;therapy development;Time;Travel;Treatment Effectiveness;treatment research;Youth

PROJECT_TITLE: Personalizing Behavioral Parent Training: Improving Reach and Outcomes for Families of Children with ADHD


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Violence Research;Youth Violence;Youth Violence Prevention

ORG_CITY: PITTSBURGH

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE Parents can help protect their adolescent children from experiencing adolescent relationship abuse (ARA), especially through parental monitoring. Hispanic immigrant parents may face challenges monitoring their adolescent children due to differences in how parents and adolescents acculturate, also called acculturation gaps. In this proposal, we apply observation-based techniques to identify which specific acculturation gaps create the most challenges to achieving optimal parental monitoring, and then incorporate those findings to develop a novel parent-adolescent ARA prevention intervention for Hispanic immigrant families.

PI_NAMEs: RAGAVAN, MAYA  (contact)

PROGRAM_OFFICER_NAME: GILBERT, LEAH KAYE

PROJECT_TERMS: 14 year old;acceptability and feasibility;Acculturation;Address;Adolescent;Adult;Advisory Committees;Age;Applied Skills;arm;career;Centers for Disease Control and Prevention (U.S.);Child;Childhood Injury;Clinical Trials Design;Code;Communication;community engagement;community partners;comparison group;Data;Development;Distress;Educational process of instructing;eligible participant;Enrollment;Environment;Epidemic;experience;Family;Foundations;Funding;Future;Generations;Goals;Health;High Prevalence;Hispanic;HIV;Immigrant;Immigrant family;innovation;Institution;Interpersonal Relations;Intervention;intimate partner violence;junior high school;K-Series Research Career Programs;Knowledge;Leadership;Link;marginalized community;Measures;Mental Depression;Mentors;Mentorship;Methods;Modeling;Monitor;multidisciplinary;National Institute of Child Health and Human Development;novel;Outcome;parental monitoring;Parents;Patient Self-Report;Performance;Physicians;pilot test;Population;prevent;Prevention;Prevention strategy;preventive intervention;primary outcome;programs;protective factors;psychologic;Public Health;randomized, clinical trials;relationship abuse;Research;Sampling;satisfaction;School-Age Population;Scientist;Sexual abuse;sexual risk behavior;skills;social cognitive theory;Strategic Planning;Stress;Structure;substance use;suicidal;Techniques;Teenagers;Testing;theories;therapy development;tool;Training;Trauma;treatment strategy;unintended pregnancy;Victimization;Video Recording;Violence;Youth

PROJECT_TITLE: Developing an Adolescent Relationship Abuse Prevention Intervention for Hispanic Immigrant Families

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Health, Behavior, and Context Study Section[CHHD-M]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Cancer;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Nutrition;Pain Research;Pancreatic Cancer;Prevention;Rare Diseases

ORG_CITY: LOS ANGELES

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

ORG_STATE: CA

PHR: NARRATIVE Chronic pancreatitis is a progressive fibro-inflammatory disorder of the exocrine pancreas that can lead to diabetes and pancreatic cancer. There are no available treatments for this fibro-inflammatory disease and patients suffer with unremitting abdominal pain as the disease progress. This pilot study will test the feasibility of conducting a clinical trial of a potent vitamin D analogue, paricalcitol, to enhance the quality of life and delay disease progression in chronic pancreatitis patients.

PI_NAMEs: GOODMAN, MARC T;PANDOL, STEPHEN J. (contact)

PROGRAM_OFFICER_NAME: UNALP-ARIDA, AYNUR

PROJECT_TERMS: Abdominal Pain;acute pancreatitis;Afferent Neurons;Alcohol abuse;analog;Animal Model;Appointment;Area;Attenuated;Biological;Biological Markers;biomarker discovery;Cancer Etiology;Cell secretion;cell type;Cessation of life;chemotherapeutic agent;chronic pain;chronic pancreatitis;Clinical;clinical development;clinical outcome measures;Clinical Trials;cohort;Collection;Conduct Clinical Trials;cytokine;Cytoplasm;Data;Desmoplastic;Development;Diabetes Mellitus;Disease;Disease Progression;DNA Sequence Alteration;Double-Blind Method;double-blind placebo controlled trial;Drug Screening;Enrollment;Ensure;Environment;epidemiology study;Evaluation;Exocrine pancreas;Extracellular Matrix Proteins;Failure;Fatality rate;FDA approved;feasibility testing;Fibrosis;follow-up;Future;Genes;Genomics;Goals;health related quality of life;High Fat Diet;high risk;Image;imaging biomarker;improved;improved outcome;Inflammatory;Intervention;Letters;Lipids;Liquid substance;Longitudinal cohort study;Macrophage;Malignant neoplasm of pancreas;Malignant Neoplasms;Measurement;Measures;Mediating;Medical Surveillance;Monitor;Myeloid Cells;Outcome;Pain;pain reduction;Pancreas;Pancreatic Diseases;Pancreatic enzyme;pancreatic stellate cell;Pancreatitis;paricalcitol;Participant;participant enrollment;Patient Outcomes Assessments;patient population;Patient Recruitments;Patients;Pilot Projects;pilot trial;Placebo Control;Placebos;pre-clinical;prevent;Process;Production;prospective;Quality of life;Randomized;recruit;Recurrence;reduce symptoms;Research;Research Design;Resources;response;response biomarker;Risk Factors;safety and feasibility;Schools;Signal Transduction;Smoking;Social Functioning;Specimen;stellate cell;Surrogate Markers;symptomatic improvement;Symptoms;Testing;TGFB1 gene;Therapeutic;therapeutically effective;therapy development;Time;Tissues;Transforming Growth Factor beta;translational study;treatment duration;treatment response;Validation;Vitamin A;Vitamin D;Vitamin D Analog;Vitamin D3 Receptor;Work

PROJECT_TITLE: A Pilot Clinical Trial of Paricalcitol for Chronic Pancreatitis

STUDY_SECTION: DNPD

STUDY_SECTION_NAME: Digestive and Nutrient Physiology and Diseases Study Section [DNPD]


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Health Services;Infectious Diseases;Orphan Drug;Rare Diseases

ORG_CITY: PORTLAND

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE Pulmonary Mycobacterium avium complex (MAC) is a chronic infection and airway inflammatory disease with systemic manifestations affecting multiple aspects of our patients' lives. This disease requires lifelong management, as recurrence is common, however our current microbiologic outcome measure is often difficult to obtain and is insufficient to reflect the impact on our patients. In order to facilitate development of a future combined disease activity measure, we aim to identify the core outcome domains and measurement instruments essential to evaluate in future clinical research studies assessing outcomes in patients with pulmonary MAC disease through an international consensus process.

PI_NAMEs: VARLEY, CARA  (contact)

PROGRAM_OFFICER_NAME: ESPINOZA-PINTUCCI, MARISOL

PROJECT_TERMS: Advocate;Affect;Antibiotics;Biological;Biological Markers;Caregivers;chronic infection;chronic inflammatory disease;Clinical;clinical care;Clinical Data;clinical practice;Clinical Research;Clinical Trials;Complex;Consensus;Data Set;Development;Disease;disease heterogeneity;disease natural history;Family member;Funding;Future;health related quality of life;improved;Incidence;Individual;Infection;Inflammatory;instrument;International;Lung;Measurement;Measures;Meta-Analysis;Methodology;mycobacterial;Mycobacterium avium Complex;novel therapeutics;Observational Study;Outcome;Outcome Assessment;Outcome Measure;Outcomes Research;Patient Education;Patient Outcomes Assessments;Patients;Process;Property;radiological imaging;Radiology Specialty;randomized, clinical trials;Rare Diseases;Recurrence;Research;Research Personnel;research study;Rheumatoid Arthritis;Sputum;success;symptomatology;Symptoms;Therapeutic Trials;treatment response;United States Food and Drug Administration

PROJECT_TITLE: Mycobacterium avium complex Core Outcomes Research (MACCOR)

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(MA)]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: Los Angeles

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: PROJECT NARRATIVE Across the biomedical sciences — from developmental biology to cancer research to immunology to epidemiology — there has been an increased recognition that many key questions in these fields can be addressed by tracking the evolution of lineages. My group has a very strong track record of making fundamental methodological contributions that have changed how biologists think about and analyze phylogenetically structured data and finding applications for these methods in new domains. Moving forward, our group’s primary aim is leveraging phylogenetic and other evolutionary approaches to gain insights into the processes that govern the evolution of gene expression, with a particular emphasis on the Immunoglobulin genes, which encode the unique recognition sequences of antibodies.

PI_NAMEs: PENNELL, MATTHEW WESLEY (contact)

PROGRAM_OFFICER_NAME: ADKINS, RONALD

PROJECT_TERMS: Address;Adopted;anti-cancer research;Antibodies;Antigens;B cell repertoire;B-Lymphocytes;Communicable Diseases;comparative;comparative genomics;Developmental Biology;dynamic system;Epidemiology;Evolution;functional genomics;Gene Expression;genomic data;Genomics;Germ Lines;Immunoglobulin Genes;Immunology;Individual;insight;inter-individual variation;interest;Methodology;Methods;Modeling;next generation;pathogen;Phenotype;Phylogenetic Analysis;Process;Promoter Regions;Research;Research Personnel;response;Science;Somatic Mutation;structured data;Testing;Thinking;Time;Variant

PROJECT_TITLE: Leveraging phylogenetic approaches to investigate the evolution of gene expression

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MGG-J(55)R]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: BALTIMORE

ORG_NAME: FRIENDS RESEARCH INSTITUTE, INC.

ORG_STATE: MD

PHR: Project Narrative Sexual (i.e., MSM) and gender (i.e., trans women) minority populations with a substance use disorder (SUD) have the two highest HIV prevalence rates in the US, which constitutes a call for action to determine scalable behavioral interventions to promote PrEP initiation, adherence and persistence. This study will implement a RCT with a Stepped Care design to determine the optimal (considering effectiveness and cost-effectiveness) intervention for advancement along the PrEP Care Continuum. The public health significance of this study is very high as the application of PrEP among SGM populations with a SUD would generate significant and lasting reductions in HIV incidence.

PI_NAMEs: MURPHY, SEAN M.;REBACK, CATHY J (contact)

PROGRAM_OFFICER_NAME: WEBB, CANDACE KARONDELETTE

PROJECT_TERMS: acceptability and feasibility;Acquired Immunodeficiency Syndrome;Adherence;Age;AIDS prevention;arm;Attention;Behavior Therapy;behavioral economics;behavioral outcome;Caring;Characteristics;cis-male;cisgender;Client;contingency management;Continuity of Patient Care;cost;cost effective intervention;cost effectiveness;Cost Effectiveness Analysis;cost estimate;County;design;Diagnosis;Economics;Education;Effectiveness;Enrollment;Epidemic;ethnic identity;experience;Food;Gender;Gender Identity;gender minority;gender minority group;Goals;Health Care Costs;Health Care Sector;health care service;health disparity;Heterosexuals;HIV;HIV Infections;HIV Seronegativity;Housing;implementation/effectiveness;Imprisonment;improve minority health;improved;Incidence;Individual;Injectable;Injections;Insurance;Intervention;Knowledge;Legal;Los Angeles;Methamphetamine;Minority;Minority Groups;Modality;Modeling;Newly Diagnosed;open label;Opioid;Oral;Outcome;overdose death;Participant;Phase;phase 2 study;Pilot Projects;Policy Maker;Population;population health;Poverty;pre-exposure prophylaxis;Prevalence;Productivity;Public Health;Quality of life;Quality-Adjusted Life Years;Race;Randomized;recruit;Reduce health disparities;reduced substance use;Reporting;Resources;response;Risk;Route;safety net;Services;Severities;Sexual and Gender Minorities;sexual minority;sexual minority group;social determinants;Social support;standard of care;State Interests;Stimulant;structural health determinants;substance use;Substance Use Disorder;System;Text Messaging;texting support;theories;Time;transgender women;truvada;United States National Institutes of Health

PROJECT_TITLE: Optimizing PrEP Implementation and Cost-effectiveness among Sexual and Gender Minority Individuals with a Substance Use Disorder


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Huntington's Disease;Neurodegenerative;Neurosciences;Rare Diseases

ORG_DEPT: PHYSIOLOGY

PHR: Project narrative The aggregation of the huntingtin protein plays an important role in Huntington’s disease, but the exact structures of the toxic species that are formed remain elusive. Using a highly interdisciplinary team, the structures of these species will be determined, thereby providing a foundation for the design of therapeutics. Moreover, means to prevent the formation of the toxic species will be developed.

PI_NAMEs: CHEN, JEANNIE ;LANGEN, RALF  (contact);SIEMER, ANSGAR B

PROGRAM_OFFICER_NAME: MILLER, DANIEL L

PROJECT_TERMS: aggregation pathway;alpha helix;Binding;Biochemical;Biological Assay;Biological Markers;Cells;conformer;Consensus;Cryoelectron Microscopy;design;Development;Disease;Epitopes;Exons;Foundations;Future;Goals;Huntington Disease;Huntington gene;inhibitor;insight;interest;Learning;Length;Methods;misfolded protein;Molecular;Molecular Chaperones;monomer;N-terminal;Neurodegenerative Disorders;Oranges;Pathogenesis;Pathogenicity;Peptides;Play;polyglutamine;Population;Positioning Attribute;prevent;Process;Proline-Rich Domain;protein aggregation;Proteins;Research;Role;solid state;Structure;Testing;Therapeutic;three dimensional structure;Toxic effect;Work

PROJECT_TITLE: Molecular Mechanism of Huntingtin Misfolding and its Inhibition by Designed and Cellular Proteins


NIH_SPENDING_CATS: Genetics

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative The circadian clock helps to align metabolic and physiological processes with changes in the environment - dysfunction in these rhythms contributes to increased risk for cardiometabolic and neurodegenerative disorders. This proposal will use a model system to resolve how circadian regulation of gene expression at the cell level is coordinated across tissues to control a physiological response. This will be achieved by building cell specific models of circadian function to characterize how cellular variation in gene expression influences complex traits.

PI_NAMEs: GREENHAM, KATHLEEN M (contact)

PROGRAM_OFFICER_NAME: AKACEM, LAMEESE DANA

PROJECT_TERMS: Arabidopsis;Biological Models;Biological Process;Cardiometabolic Disease;cardiometabolic risk;cell type;Cells;circadian;circadian pacemaker;circadian regulation;Circadian Rhythms;Communication;Complex;Environment;fitness;Functional disorder;Gene Expression;Gene Expression Regulation;gene regulatory network;Genes;Genetic;Genetic Transcription;Goals;Health;Human;insight;Metabolic;Metabolism;model organism;Modeling;Molecular;Mouse-ear Cress;network models;Neurodegenerative Disorders;Organ;Physiological;Physiological Processes;Plants;Power Plants;Research;Resolution;response;single cell technology;System;targeted treatment;Time;Tissues;trait;Variant;Whole Organism;Work

PROJECT_TITLE: Resolving the spatial dynamics of single cell circadian regulatory networks

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-L(55)R]


NIH_SPENDING_CATS: Biotechnology;Genetics;Infectious Diseases;Sexually Transmitted Infections

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

PHR: Project Narrative Herpes Simplex Virus types 1 and 2 are ubiquitous pathogens that are widespread in the population and cause a variety of diseases including oral lesions, genital ulcers, and ocular infections that can result in blindness. Our goal is to contribute to the understand of the basic mechanisms of viral DNA replication which will contribute to the design of antiviral therapies.

PI_NAMEs: MOHNI, KAREEM N (contact)

PROGRAM_OFFICER_NAME: REDDY, MICHAEL K

PROJECT_TERMS: Amino Acids;Anti-viral Therapy;Area;Binding Proteins;Blindness;Cell Culture Techniques;Cell Nucleus;Cells;Chromatin;Complex;Coupled;Data Set;design;Deubiquitinating Enzyme;Disease;DNA;DNA biosynthesis;DNA Maintenance;DNA Primase;DNA replication fork;Double Stranded DNA Virus;Eye Infections;Genitalia;Genome;Goals;helicase;Herpesvirus 1;Human;Laboratories;Methods;oral lesion;pathogen;Physiologic pulse;Polymerase;Population;Proteins;Proteomics;recombinase;repaired;Research;Research Proposals;Sampling;Set protein;spleen exonuclease;SS DNA BP;Stable Isotope Labeling;tool;ubiquitin isopeptidase;Ulcer;Viral;viral DNA;Viral Genome;Viral Proteins;Virus Replication

PROJECT_TITLE: Proteomics of HSV1 Replication

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Cannabinoid Research;Clinical Research;Drug Abuse (NIDA only);Mental Health;Mental Illness;Pediatric;Schizophrenia;Serious Mental Illness;Social Determinants of Health;Substance Misuse

ORG_CITY: COLUMBUS

ORG_NAME: RESEARCH INST NATIONWIDE CHILDREN'S HOSP

ORG_STATE: OH

PHR: PROJECT NARRATIVE Over the last several decades, state laws governing sales and possession of cannabis products have changed dramatically with minimal scientific evidence available to inform policymakers. Medicaid-enrolled adolescents and young adults have higher prevalence rates of mental health and substance use disorders and poorer physical and mental health outcomes compared to age matched peers; thus they are a large vulnerable population in whom the MML and RML effects are unknown. We will analyze national Medicaid data to determine MML and RML effects on cannabis use disorder, serious mental illness, non-cannabis substance use disorder, suicide-related outcomes, all-cause mortality, and treatment utilization for SU and MH service in American youth.

PI_NAMEs: FONTANELLA, CYNTHIA ANN (contact);HAMMOND, CHRISTOPHER J.

PROGRAM_OFFICER_NAME: LYNCH, SEAN EDWARD WINTERS

PROJECT_TERMS: Achievement;Adolescent;Adolescent and Young Adult;Adult;Affect;Age;aged;American;Behavior;Cannabis;Cannabis policy;Cessation of life;Classification;clinical care;Data;Development;District of Columbia;Drug Prescriptions;Emergency department visit;Enrollment;Exhibits;experience;Goals;Health;Health Benefit;Heterogeneity;High Prevalence;Hospitalization;illicit drug use;indexing;Individual;interest;Intervention;Knowledge;Laws;Legal;marijuana legalization;marijuana use;marijuana use disorder;Mediating;Medicaid;Medical;Medical Marijuana;Mental Health;Mental Health Services;Modeling;mortality;multilevel analysis;National Institute of Drug Abuse;Occupations;opioid overdose;Outcome;outcome disparities;Outpatients;overdose death;Pattern;peer;Perception;Pharmaceutical Preparations;physical conditioning;Policies;Policy Maker;Policy Making;poor health outcome;Population;population health;Positioning Attribute;Prevalence;Privatization;programs;Public Health;Public Policy;Quasi-experiment;Records;Recreation;Research;Residential Treatment;Risk;Risk Taking;Sales;Sampling;Science;severe mental illness;study population;substance use;Substance Use Disorder;substance use treatment;Suicide;Taxonomy;Teenagers;US State;vehicular accident;Vulnerable Populations;Work;young adult;Youth

PROJECT_TITLE: Impact of Recreational and Medical Marijuana legalization on cannabis use disorders, serious mental illness, and mortality outcomes among Medicaid enrolled youth


NIH_SPENDING_CATS: Brain Disorders;Drug Abuse (NIDA only);Neurosciences;Opioid Misuse and Addiction;Opioids;Pain Research;Prevention;Substance Misuse

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative Opioids are potent pain relievers, however they can be addictive and their overuse has produced the opioid overdose epidemic, with hundreds of thousands of deaths. We now report that changes in behavior and in the brain correlated with addiction can be prevented, while analgesia is maintained, when a dual hypocretin/orexin receptor antagonist is given along with morphine. We propose to systematically document the receptor specificity, dose-response, time course and neuronal substrates of this interaction as a first step towards the use of an Hcrt antagonist in combination with opioids as a highly effective, non- addictive pain treatment in humans.

PI_NAMEs: SIEGEL, JEROME M (contact)

PROGRAM_OFFICER_NAME: ANANTHAN, SUBRAMANIAM

PROJECT_TERMS: Ablation;Absence of pain sensation;Action Potentials;addiction;Affect;Analgesics;Anatomy;antagonist;Axon;Behavior;Brain;Cessation of life;Chronic;Cocaine;compare effectiveness;Confocal Microscopy;Data;Development;Dose;Drug abuse;Effectiveness;Epidemic;Fentanyl;Food;Heroin;Human;hypocretin;in vivo calcium imaging;Induced Neurons;Intake;Laboratories;Link;locus ceruleus structure;Measures;medical malpractice;Morphine;morphine administration;Mus;Naloxone;Narcolepsy;nerve supply;neurogenesis;Neurons;Non-Steroidal Anti-Inflammatory Agents;Opiate Addiction;Opioid;Opioid Analgesics;opioid mortality;opioid overdose;Opioid Receptor;opioid use disorder;orexin A receptor;orexin B receptor;Pain;Pain management;Peptides;Pharmaceutical Preparations;Physicians;prescription opioid;preservation;prevent;Rattus;receptor;Reporting;response;Risk;Role;Running;Secure;Shapes;Specificity;Substantia nigra structure;Substrate Interaction;Symptoms;Testing;Time;Tyrosine 3-Monooxygenase;Ventral Tegmental Area;Work

PROJECT_TITLE: Maintaining opioid analgesia and preventing addiction with hypocretin antagonism

STUDY_SECTION: BNRS

STUDY_SECTION_NAME: Behavioral Neuroendocrinology, Neuroimmunology, Rhythms, and Sleep Study Section [BNRS]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Childhood Leukemia;Clinical Research;Genetics;Hematology;Human Genome;Pediatric;Pediatric Cancer;Perinatal Period - Conditions Originating in Perinatal Period;Prevention;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Umbilical Cord Blood/ Placenta;Stem Cell Research - Umbilical Cord Blood/ Placenta - Human

PHR: Narrative Acute leukemias are the most common form of cancer in children. Many types of acute leukemia are known to initiate in utero, but a comprehensive natural history and epidemiologic study of in utero leukemogenesis is lacking. We will collect and assay cord blood and matched leukemia samples from ~182 children with acute leukemia to lay the groundwork for future screening and prevention efforts.

PI_NAMEs: DE SMITH, ADAM ;SPECTOR, LOGAN G. (contact)

PROGRAM_OFFICER_NAME: KLAUZINSKA, MALGORZATA

PROJECT_TERMS: 15 year old;Acute leukemia;Acute Lymphocytic Leukemia;Acute Myelocytic Leukemia;Architecture;Biological Assay;Birth;Birth Records;Birth Weight;Blood;Blood Cells;Blood specimen;Cause of Death;CBFA2T1 gene;CD34 gene;Cell Separation;cell type;Cells;Cesarean section;Child;Childhood Acute Lymphocytic Leukemia;Childhood Leukemia;Cohort Studies;Data;Development;Diagnostic;digital;disorder risk;DNA Sequence Alteration;driver mutation;Dryness;Eligibility Determination;epidemiology study;Ethnic Origin;Etiology;ETV6 gene;Event;Face;Frequencies;Future;Gene Expression;Gene Expression Profile;Gene Fusion;Generations;Genetic;genetic risk factor;genome sequencing;Genotype;Goals;Hematopoietic;high risk;Immunophenotyping;in utero;indexing;individualized prevention;Lesion;leukemia;leukemogenesis;Malignant Childhood Neoplasm;Measures;MLL gene;Morbidity - disease rate;Mutation;Natural History;Neonatal;Neonatal Leukemia;Neonatal Screening;Newborn Infant;Parental Ages;Patients;Pediatric Oncology Group;Perinatal;Point Mutation;Population;Preleukemia;prenatal;Prevention;Preventive;progenitor;Race;Resolution;Risk Factors;risk prediction model;RUNX1 gene;Sampling;screening;sex;Somatic Mutation;Sorting;Spottings;stem;Surveys;Survivors;Testing;transcriptome sequencing;transcriptomics;tumor;Umbilical Cord Blood;whole genome

PROJECT_TITLE: Backtracking Leukemia-Typical Somatic Alterations in Cord Blood at Single-cell Resolution

STUDY_SECTION: CG

STUDY_SECTION_NAME: Cancer Genetics Study Section[CG]


NIH_SPENDING_CATS: Aging;Atherosclerosis;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Heart Disease;Heart Disease - Coronary Heart Disease;Kidney Disease;Prevention

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: NARRATIVE Many patients with chronic kidney disease develop heart failure, but the underlying causes remain unclear. Animal models of human disease suggest that the inflammasome may contribute to the development of heart failure in patients with chronic kidney disease. An epidemiologic study and a clinical trial will be conducted to improve our understanding of the role of inflammasome activity in the development of heart failure among adults with chronic kidney disease.

PI_NAMEs: BUCKLEY, LEO FRANCIS (contact)

PROGRAM_OFFICER_NAME: REDMOND, NICOLE

PROJECT_TERMS: Ablation;Acute myocardial infarction;Adult;anakinra;Animal Model;Anti-Inflammatory Agents;Area;Atherosclerosis;Atherosclerosis Risk in Communities;Award;C-reactive protein;Cardiac;cardiovascular pharmacology;Cardiovascular system;career;CASP1 gene;Chronic Kidney Failure;Clinical;clinical trial participant;Clinical Trials;Colchicine;Complex;Coronary Arteriosclerosis;Cross-Over Trials;cytokine;Data Analyses;Dedications;design;Development;Doctor of Pharmacy;Double-Blind Method;Echocardiography;Environment;Epidemiology;epidemiology study;exercise capacity;flexibility;Fostering;Functional disorder;Goals;Heart failure;heart failure with reduced ejection fraction;Hospitalization;Host Defense;Human;human disease;human model;human monoclonal antibodies;IL18 gene;Immunology;Impairment;improved;indexing;Inflammasome;Inflammation Mediators;Inflammatory;inhibitor;interest;Interleukin-1;Interleukin-1 beta;Interleukins;Investigation;Kidney;Knowledge;Left;Left Ventricular Dysfunction;Left Ventricular Remodeling;Mediating;Mediator;Mentors;Mentorship;Methodology;Modeling;Modification;Molecular;monocyte;Myocardial;Myocardial Infarction;Myocarditis;older adult;overexpression;Participant;Pathogenesis;Pathway interactions;patient oriented;patient oriented research;Patients;Peptide Hydrolases;pharmacologic;Pharmacotherapy;Placebo Control;Placebos;Plasma;Play;preservation;prevent;primary endpoint;Principal Investigator;Production;programs;Proteins;Randomized;Recombinants;Research;Research Personnel;Risk;Risk Factors;Role;Series;Structure;systemic inflammatory response;Systolic heart failure;Testing;Training;trend;uremic cardiomyopathy;Ventricular;Wild Type Mouse

PROJECT_TITLE: Inflammasome Activity as a Potential Contributor to Uremic Cardiomyopathy


NIH_SPENDING_CATS: Breast Cancer;Cancer;Hematology;Lung;Women's Health Research

PHR: PROJECT NARRATIVE Because metastasis remains the major cause of mortality for breast cancer patients, understanding the mechanisms underpinning its progression is crucial for developing drugs that target this deadly process. My research proposal will expand our fundamental knowledge of tumor metastasis by investigating how blood platelets promote the formation of tumor cell-permissive sites, commonly referred to as the “pre-metastatic niche”. The overarching goal is to develop platelet-targeting adjuvant and preventative therapeutic strategies that improve the outcomes of patients at risk of metastatic breast cancer.

PI_NAMEs: ROWETH, HARVEY GEORGE (contact)

PROGRAM_OFFICER_NAME: JAKOWLEW, SONIA B

PROJECT_TERMS: Adjuvant;Adjuvant Therapy;Adopted;Advisory Committees;Affect;angiogenesis;Antiplatelet Drugs;Attention;Award;Blood Platelets;Blood Vessels;Bone Marrow;breast cancer metastasis;Breast Cancer Patient;Breast Cancer therapy;Cancer Biology;cancer cell;cancer therapy;career development;Cell Physiology;Cell Survival;Cells;Cessation of life;Circulation;Clinical;Communication;curative treatments;CXCL5 gene;cytokine;Data;design;Development Plans;Disease;Distant;Distant Metastasis;Drug Targeting;Environment;Goals;Hematology;Hemostatic function;Hospitals;Immune;Impairment;improved outcome;Inflammation;Inflammatory;inflammatory lung disease;Knowledge;Laboratory Research;Leadership;Leukocytes;Lung;Malignant Breast Neoplasm;Malignant Neoplasms;Megakaryocytes;Mentorship;Metastatic breast cancer;Metastatic Neoplasm to the Lung;monocyte;mortality;Mus;Myelogenous;Myeloid Cells;Neoplasm Circulating Cells;Neoplasm Metastasis;neoplastic cell;novel;Organ;Outcome;Patient-Focused Outcomes;Patients;permissiveness;Pharmaceutical Preparations;Phase;Platelet Activation;Platelet Count measurement;platelet function;Pre-Clinical Model;preservation;Preventive;Primary Neoplasm;Process;Production;programs;Protein-Lysine 6-Oxidase;Pulmonary Inflammation;recruit;Research;Research Personnel;Research Proposals;Risk;Role;S100A8 gene;Series;Signal Transduction;Site;skills;Small Interfering RNA;T-Lymphocyte;Technical Expertise;Testing;Therapeutic;therapeutic evaluation;Therapeutic Research;therapeutic target;Toxic effect;transcriptomics;triple-negative invasive breast carcinoma;tumor;Tumor Cell Invasion;Tumor-Derived;tumor-immune system interactions;United States;Woman

PROJECT_TITLE: The Role of Platelets in Establishing the Lung Pre-Metastatic Niche in Breast Cancer

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Transition to Independence Study Section (I)[NCI-I]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Immunotherapy;Lung;Lung Cancer

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

PHR: Narrative NF-κB plays a causative role in the pathogenesis of various diseases such as lung cancer, the leading cause of cancer-related deaths in both men and women. However, we have been unable to successfully target it for clinical treatment due to its equally important roles in physiology and host defense in particular. The proposed investigations will dissect the differential regulation and action of NF-κB in lung cancer and physiologic host defense against pulmonary infection. These studies may lead to new clinically feasible approaches to selectively target pathogenic NF-κB for therapy.

PI_NAMEs: QU, ZHAOXIA  (contact);XIAO, GUTIAN

PROGRAM_OFFICER_NAME: XU, WANPING

PROJECT_TERMS: Acetylation;Age Months;anti-PD-1;Atlases;Automobile Driving;Cancer cell line;Cancer Etiology;Cancer Patient;cancer therapy;cell growth;Cells;Cessation of life;Chemoresistance;chemotherapeutic agent;chemotherapy;ChIP-seq;Clinic;Clinical;Clinical Treatment;Combined Modality Therapy;conditional knockout;Data;Databases;Development;Disease;Disease remission;Ectopic Expression;effective therapy;Embryo;epigenetic drug;Epithelium;Family;fighting;Genes;Histologic;Host Defense;Human;Immune;immune checkpoint blockade;Immune response;Immunity;Immunology procedure;Immunotherapy;improved;improved outcome;In Vitro;in vivo;Inflammatory;innovation;Investigation;Knock-in Mouse;Knock-out;Knockout Mice;LIM Domain;Link;Lung;lung cancer cell;Lung infections;Lung Neoplasms;lung tumorigenesis;Malignant neoplasm of lung;Malignant Neoplasms;member;men;mimetics;Modification;Molecular;mouse model;Mus;neoplastic cell;NF-kappa B;Normal Cell;novel;Nuclear;Oncogenic;p65;Pathogenesis;Pathogenicity;Pathologic;Pathology;Pattern;PD-1 blockade;Pharmaceutical Preparations;pharmacologic;Physiological;Physiology;Play;prevent;Prognosis;programmed cell death protein 1;Proteins;Regulation;RELA gene;Repression;Resistance;response;restoration;Role;Safety;Signal Induction;Signal Transduction;single-cell RNA sequencing;Specificity;Survival Rate;synergism;Testing;The Cancer Genome Atlas;Therapeutic;therapy resistant;Time;transcription factor;tumor;Tumor Promoters;Tumor Suppressor Proteins;tumorigenesis;ubiquitin-protein ligase;Virus Diseases;Woman

PROJECT_TITLE: Mechanistic difference of NF-kappaB in lung physiology and tumorigenesis

STUDY_SECTION: MONC

STUDY_SECTION_NAME: Molecular Oncogenesis Study Section[MONC]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Breast Cancer;Cancer;Genetics;Infectious Diseases;Women's Health Research

ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: Project Narrative Elucidation of the mechanism that mediates resistance to retroviruses is of fundamental importance to human health, as it will ultimately lead to knowledge of the genetic differences among individuals in susceptibility to microbial infections.

PI_NAMEs: GOLOVKINA, TATYANA V (contact)

PROGRAM_OFFICER_NAME: PARK, EUN-CHUNG

PROJECT_TERMS: Alleles;Antibodies;attenuation;Automobile Driving;Candidate Disease Gene;candidate identification;Chromosome 18;Computer Analysis;cytotoxic CD8 T cells;Cytotoxic T-Lymphocytes;Disease;Dominant Genes;Exhibits;experimental study;Generations;Genes;Genetic;genetic makeup;Genetic Predisposition to Disease;Genetic study;Goals;Health;HIV;Human;human pathogen;Immune response;Inbred Mouse;Individual;Infection;Inherited;Knowledge;Lymphocyte;Lymphoid Cell;Mammary gland;Mammary Neoplasms;mammary tumor virus;Mammary Tumorigenesis;Maps;Mediating;microbial;Milk;Modeling;Mouse Mammary Tumor Virus;Mouse Strains;Mucous Membrane;Mus;Names;Natural Killer Cells;neutralizing antibody;pathogen;pathogenic virus;Population;Predisposition;pup;Resistance;resistance gene;resistance mechanism;response;Retroviridae;Study models;suckling;Susceptibility Gene;T-Lymphocyte and Natural Killer Cell;Therapeutic;transmission process;tumor;Tumor Virus Infections;tumorigenesis;Vaccines;Variant;Viral;Virus;Virus Diseases;Virus Replication;YBR Mouse

PROJECT_TITLE: Identification of the gene controlling murine retrovirus in YBR mice

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-VDT-Q(01)]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Aging;Arthritis;Bioengineering;Biotechnology;Clinical Research;Osteoarthritis;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine

ORG_CITY: MANCHESTER

ORG_NAME: PRO THERAPEUTICS LLC

ORG_STATE: NH

PHR: PROJECT NARRATIVE More than 350,000 anterior cruciate ligament (ACL) reconstruction surgeries are performed in the US each year [1], and billions are spent on the acute care costs involved in these procedures. STEL Technologies has developed the first fully biologic graft for ACL repair and demonstrated superiority to the standard of care in clinically relevant, large animal model of ACL injury. The CGEM graft is an innovative and paradigm-shifting approach to ligament replacement that facilitates native repair of the ACL and regeneration of enthesis, leading to restoration of normal biomechanics and mobility. We have spent 9 years developing the technology and are now prepared to launch a first-in-human clinical trial to demonstrate improved knee stability and function, and the possibility of a radical improvement in outcomes for patients who suffer acute knee injury including decreased risk of re-injury and arthritis.

PI_NAMEs: JAKUS, ADAM EDWARD (contact)

PROGRAM_OFFICER_NAME: WASHABAUGH, CHARLES H

PROJECT_TERMS: Acceleration;Acute;acute care;Animal Model;Animals;Anterior Cruciate Ligament;anterior cruciate ligament injury;anterior cruciate ligament reconstruction;Applications Grants;Arthritis;Biological;Biological Products;Biomechanics;Budgets;Capital;care costs;Cells;Childhood;Clinical;Clinical Research;clinical trial readiness;Clinical Trials;Clinical Trials Support Unit;clinically relevant;Collaborations;Communities;Complex;cost;Data;Degenerative polyarthritis;design;Development;Documentation;early onset;Economic Development;Ensure;Evaluation;first-in-human;follow-up;Foundations;Fright;Gait;Goals;Golf;graft failure;Grant;Healthcare;high risk;Human;improved;Incidence;Injury;innovation;Institutional Review Boards;Investigational Drugs;Investigational New Drug Application;Investments;Joint Instability;Knee;Knee Injuries;Knee joint;knee replacement arthroplasty;Laboratories;laboratory equipment;Ligaments;Manuals;Measurement;Mechanoreceptors;Michigan;Monitor;Movement;Muscle function;Natural regeneration;Operative Surgical Procedures;Orthopedics;Outcome;Patient-Focused Outcomes;Patients;Phase I Clinical Trials;Play;Positioning Attribute;pre-Investigational New Drug meeting;Probability;procedure cost;Procedures;programs;Protocols documentation;Quality of life;randomized, clinical trials;Reconstructive Surgical Procedures;Regenerative capacity;Regenerative Medicine;repaired;Research;Research Personnel;restoration;Risk;Risk Factors;Safety;scaffold;Site;skeletal tissue;soft tissue;Solid;Speed;standard of care;Statistical Data Interpretation;success;Surgeon;Talents;Technical Expertise;Technology;Tendon structure;Testing;Tissue Engineering;Tissues;trial planning;United States Food and Drug Administration;United States National Institutes of Health;Universities

PROJECT_TITLE: Planning for clinical trial of fully-biologic, cell generated graft (CGEM) for ACLrepair

STUDY_SECTION: AMSC

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Clinical Trials Study Section [AMSC]


ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Develop engineered receptor regulatory T cell therapy with single antigen specificity and physiological T cell receptor signaling to suppress anti-drug antibody formation durably and specifically in a model of clotting factor replacement therapy in hemophilia.

PI_NAMEs: BISWAS, MOANARO  (contact)

PROGRAM_OFFICER_NAME: GILLASPY, ALLISON

PROJECT_TERMS: Acute Disease;Address;Adoptive Transfer;Allogenic;Antibodies;Antibody Formation;Antibody Response;Antigens;Autoimmune Diseases;Autoimmunity;Autologous;Biological Response Modifier Therapy;Biomedical Engineering;Blood Coagulation Factor;Bypass;CD28 gene;CD3 Antigens;Cell Count;Cell Therapy;chimeric antigen receptor;clinical application;clinical translation;Clustered Regularly Interspaced Short Palindromic Repeats;cost;Data;design;Development;Disease;Dose;Engineering;enzyme replacement therapy;extracellular;Factor VIII;Failure;flexibility;Frequencies;Generations;Genes;Goals;Grant;Hemophilia A;Human;Hybrids;IL2 gene;Immune response;Immune System Diseases;Immunity;Immunosuppression;improved;In Vitro;in vivo;innovation;Interleukin-2;Knock-out;Laboratories;manufacture;Mediating;Mediator;Modeling;Molecular;Monoclonal Antibodies;novel;pathogen;Pathogenicity;Pathway interactions;Patients;Pharmaceutical Preparations;Phenotype;Physiological;pre-clinical;preservation;prevent;Process;Proliferating;promoter;Protein Engineering;receptor;receptor expression;Receptor Signaling;Regulatory T-Lymphocyte;repaired;Replacement Therapy;Risk;Signal Transduction;Signaling Molecule;Specificity;Structure;Surface;T cell therapy;T-Cell Receptor;T-Lymphocyte;Technology;Therapeutic;Time;Transplantation;Transplantation Tolerance

PROJECT_TITLE: Development of a cellular therapy product with single specificity and improved persistence to prevent immunity to biotherapeutics

STUDY_SECTION: TAG

STUDY_SECTION_NAME: Therapeutic Approaches to Genetic Diseases Study Section[TAG]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Mental Health;Mental Illness;Prevention;Serious Mental Illness;Sleep Research;Suicide;Suicide Prevention

PHR: PROJECT NARRATIVE Bereaved persons are approximately three times more likely than non-bereaved persons to die by suicide. The loss of a spouse during late life is also associated with a felt sense of social disconnection, lack of engagement in pleasant activities, and disruptions in daily routines. The objective of this R01 application is to examine risk and resilience to late-life suicide following spousal bereavement by investigating the extent to which social connectedness influences suicide risk and whether circadian rhythm instability (i.e., inconsistent patterns of social activity, sleep, and meals) helps explain this association. The proposed study uses longitudinal observation and behavioral probe methods to determine whether directly targeting social disconnectedness decreases suicide risk among older bereaved spouses.

PI_NAMEs: STAHL, SARAH T (contact);SZANTO, KATALIN

PROGRAM_OFFICER_NAME: LYONS, ELIZABETH ANNE

PROJECT_TERMS: acceptability and feasibility;actigraphy;Acute;Adult;Age;age related;Behavior;Behavioral;Behavioral Mechanisms;Bereavement;biobehavior;Biological;Cessation of life;circadian;Circadian Rhythms;Clinical;Clinical assessments;Data;depressive symptoms;design;digital health;Dimensions;Disease remission;Distress;Elderly;Enrollment;Event;experience;Feeling;Feeling suicidal;geriatric depression;high dimensionality;Hour;human old age (65+);ideation;improved;Individual;individual variation;Intervention;Investigation;Investigational Therapies;late life;Life;Life Style;Loneliness;longitudinal design;Measures;Mediator;Mental Depression;Methods;mortality;Natural experiment;Participant;Pathway interactions;Pattern;Periodicity;person centered;Persons;Phase;prospective;Recording of previous events;reducing suicide;Research;resilience;Rest;Risk;Risk Factors;Self Care;sex;Sleep;sleep onset;sleep pattern;social;Social Change;social integration;social stressor;Socialization;Spouses;Statistical Models;suicidal;suicidal behavior;suicidal morbidity;suicidal risk;Suicide;Suicide attempt;Testing;therapy development;Time;Widow;Withdrawal

PROJECT_TITLE: Risk and resilience to late-life suicidal ideation and behavior after spousal bereavement:  Targeting social connectedness to strengthen circadian rhythmicity


ORG_CITY: DALLAS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: PROJECT NARRATIVE The melanocortin system represents a fundamental component of metabolic, body weight and glucose regulation, but it is unclear which endogenous melanocortin peptides are required for normal metabolic responses. We will use our newly developed mouse models targeting α-MSH to test whether deletion of α- MSH impairs adaptive response to surviving metabolic challenges and to determine the specific neurons or organs that are responsible for α-MSH actions on metabolism.

PI_NAMEs: ELMQUIST, JOEL K. (contact);MOUNTJOY, KATHY

PROGRAM_OFFICER_NAME: COOKE, BRAD

PROJECT_TERMS: Adipose tissue;Affect;Aminobutyric Acids;Attenuated;beta-Endorphin;Blood Glucose;blood glucose regulation;Body Weight;Brain;cell type;Cells;Dependovirus;Development;Diabetes Mellitus;Eating;Endocrine;energy balance;Energy Metabolism;Enterobacteria phage P1 Cre recombinase;Exercise;falls;Fasting;Food Energy;Genetic Engineering;glucose metabolism;glucose production;Glutamates;Goals;Hepatic;Homeostasis;Hypothalamic structure;Impairment;Leptin;Leptin deficiency;leptin receptor;Liver;LoxP-flanked allele;Maps;Mass Spectrum Analysis;Measures;Mediating;Melanocyte stimulating hormone;Metabolic;Metabolism;Modeling;mouse genetics;mouse model;Mus;Neurons;neurotransmitter release;novel;Obesity;optogenetics;Organ;pars intermedia;Peptides;Physiological;Physiological Processes;Pituitary Gland;Point Mutation;Population;Population Heterogeneity;Pro-Opiomelanocortin;Production;Protein Isoforms;Proteins;Regulation;response;Role;Site;Structure of nucleus infundibularis hypothalami;System;Testing;Tissues;Transgenic Mice;α-Melanocyte stimulating hormone

PROJECT_TITLE: Interactions of Leptin and the Melanocortin System

STUDY_SECTION: POMD

STUDY_SECTION_NAME: Pathophysiology of Obesity and Metabolic Disease Study Section[POMD]


NIH_SPENDING_CATS: Assistive Technology;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Hearing Loss;Mental Health;Prevention;Rehabilitation

ORG_DEPT: OTHER HEALTH PROFESSIONS

PHR: PROJECT NARRATIVE People with hearing loss experience extra effort when listening, which can lead to severe psychological barriers to communication and social participation. Listening effort can lead to fatigue, mental strain, burnout, medical sick leave, and the need for increased time to recover from regular daily activities. This proposal aims to understand effort changes on a moment-to-moment basis during listening, how long the effort lasts, and how the planning and execution of effort is impacted by the experience of using a cochlear implant.

PI_NAMEs: WINN, MATTHEW BRANDON (contact)

PROGRAM_OFFICER_NAME: KING, KELLY ANNE

PROJECT_TITLE: Listening effort in cochlear implant users

STUDY_SECTION: LCOM

STUDY_SECTION_NAME: Language and Communication Study Section[LCOM]


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Genetics;Human Genome

ORG_CITY: IRVINE

ORG_DEPT: DERMATOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: PROJECT NARRATIVE: Vitiligo affects 0.5% to 4% of the population worldwide and response to phototherapy is often partial. This proposal aims to elucidate why within a single vitiligo lesion there are areas that respond and others that do not. The results will provide new insights on treatment responses to nbUVB and help us understand whether targeting the local environment is sufficient to promote repigmentaiton.

PI_NAMEs: SHIU, JESSICA  (contact)

PROGRAM_OFFICER_NAME: BELKIN, ALEXEY

PROJECT_TERMS: Affect;Aftercare;Area;Autoimmune;autoreactivity;Biology;Biopsy;CD8-Positive T-Lymphocytes;Cell Communication;Cell model;Cells;Cellular biology;Cellular Stress;chemokine;Chronic;Combined Modality Therapy;Consumption;Cutaneous;CXCL9 gene;CXCR3 gene;density;Dermatology;design;Development;Disease;Doctor of Philosophy;Environment;Equilibrium;experience;Funding;Gene Expression;Genomics;Hair follicle structure;Homeostasis;Image;Immune;Immune response;Immunity;Immunosuppressive Agents;in vivo imaging;Inflammation;Injury;insight;keratinocyte;Left;Lesion;Location;Maps;Measures;melanocyte;Mentors;Metabolic;Methods;microscopic imaging;migration;Modeling;mouse model;multiphoton microscopy;non-invasive imaging;novel therapeutics;Patient imaging;Patients;Phototherapy;Physicians;Pigmentation physiologic function;Pigments;Population;Population Dynamics;Positioning Attribute;Process;psychological distress;Publishing;recruit;Research;Research Personnel;Resistance;Resources;response;Scientist;Shapes;Signal Induction;Signal Transduction;single cell genomics;single-cell RNA sequencing;Skin;skin disorder;standard care;Steroids;Stress;T-Cell Activation;T-Lymphocyte;Technical Expertise;Testing;Thromboplastin;Time;Training;transcriptomics;treatment response;Ultraviolet B Radiation;Vitiligo;WNT Signaling Pathway;Work;wound

PROJECT_TITLE: Determining how local factors influence repigmentation in stable vitiligo


ED_INST_TYPE: SCHOOLS OF PHARMACY

ORG_CITY: Chicago

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: PROJECT NARRATIVE Viral replication requires the formation of infectious particle through the bottom-up self-assembly of each individual virion. Cellular mechanisms are commonly used to guide the process toward the correctly assembled structure. This project aims to exploit this inherent vulnerability in the viral life cycle, and will yield innovative therapeutic strategies to drive the formation of aberrant viral structures using peptides that mimic native initiators of self-assembly.

PI_NAMEs: VILLEGAS, JOSE ABRAHAM (contact)

PROGRAM_OFFICER_NAME: MCDONALD, DAVID JOSEPH

PROJECT_TERMS: 3-Dimensional;Affinity;antiviral drug development;Area;Attention;Binding;Capsid;Capsid Proteins;Cell membrane;Cell Membrane Permeability;Cell Physiology;Cells;Conserved Sequence;design;Development;drug discovery;Drug resistance;Electron Microscopy;Elements;Fiber;fitness;Fluorescence Microscopy;gag Gene Products;Genetic;genetic variant;Genomics;Geometry;Goals;HIV;HIV anti-retroviral;HIV-1;Hydrophobicity;in vivo;Individual;Infection;innovation;interest;Interferometry;Life Cycle Stages;light scattering;Lipids;Liquid substance;Mass Spectrum Analysis;Membrane;mimetics;Monitor;Morphology;Mutation;Nature;novel;Nucleic Acid Binding;Nucleocapsid;Nucleotides;particle;Pathway interactions;Peptides;peptidomimetics;Pharmaceutical Preparations;Physical condensation;Play;Polyproteins;Post-Translational Protein Processing;prevent;Process;Production;Proteins;recruit;Research;Resistance development;RNA Viruses;Role;Sampling;self assembly;Signal Transduction;single molecule;small molecule;SP1 gene;Structure;Surface;targeted treatment;Therapeutic;transmission process;two-dimensional;vaccine immunogenicity;Variant;Viral;Viral Drug Resistance;viral fitness;Viral Genome;Viral Proteins;viral RNA;Virion;Virus;Virus Assembly;Virus Inactivation;Virus Replication;Visualization

PROJECT_TITLE: Inducing Off-pathway Assembly of HIV Gag Polyprotein with Computationally Designed Peptides


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Data Science;Dementia;Machine Learning and Artificial Intelligence;Neurodegenerative;Neurosciences;Prevention

ORG_DEPT: OTHER BASIC SCIENCES

PHR: Project Narrative Alzheimer’s disease poses a large public health challenge not only for the nearly 6 million Americans affected but also for their families, caregivers, and communities. To enable better disease detection, this proposal aims to develop a reliable, multimodal, and multiclass classifier for Alzheimer’s prediction of clinical diagnosis and biomarker status. In the long term, achieving the proposed aims will establish a framework for earlier detection of disease risk, improve stratification of patients for more effective clinical trials, and expand our ability to differentially diagnose Alzheimer’s disease and related dementias.

PI_NAMEs: REN, YUEQI  (contact)

PROGRAM_OFFICER_NAME: LUO, YUAN

PROJECT_TERMS: Address;Affect;Aging;Alzheimer disease detection;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease related dementia;Alzheimer's disease risk;Alzheimer’s disease biomarker;American;Amyloid;Amyloid beta-Protein;Apolipoprotein E;Area;Behavioral;Biological Markers;California;career;Caregivers;Classification;Clinical;clinical biomarkers;clinical development;clinical diagnosis;clinical practice;clinical predictors;Clinical Treatment;Clinical Trials;Cognition;Communities;Data;data fusion;data imputation;Data Science;Data Set;Dementia;design;Detection;Development;Diagnosis;Differential Diagnosis;Dimensions;Disease;Disease Progression;disorder risk;Early Diagnosis;Environment;experimental study;Family;Fellowship;Funding;Genotype;Goals;improved;insight;Institution;Joints;Knowledge;large datasets;Lasso;Machine Learning;machine learning classifier;machine learning model;Magnetic Resonance Imaging;Mentorship;Meta-Analysis;Methods;mild cognitive impairment;Modality;Modeling;multimodal data;multimodal fusion;multimodality;Nature;neuroimaging;neuropsychiatry;older adult;Outcome;outcome prediction;Pathology;patient stratification;Physicians;Positron-Emission Tomography;predictive modeling;Public Health;Quality of life;random forest;Research;Risk;Scientist;screening;Signal Transduction;statistical and machine learning;statistics;tau Proteins;Techniques;Therapeutic;therapy outcome;Training;Universities;Validation;Work

PROJECT_TITLE: Multimodal, multiclass prediction of disease status in Alzheimer’s

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F18-E(20)]


NIH_SPENDING_CATS: Contraception/Reproduction;Infertility

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: PROJECT RELEVANCE Reproductive science and medicine encompasses the study of endocrinology, gonad development, gametogenesis and embryogenesis, and reproductive tract biology and research in this area has implications for fertility, contraception, pregnancy, fetal origins of adult disease, transgenerational epigenetic inheritance, aging, cancers, infectious diseases, and more. This application will fund the Upper Midwest Summit for Reproductive Science (UMSRS), which will coalesce reproductive science and medicine research across 16 institutions in five states in the Upper Midwest region (Illinois, Indiana, Kentucky, Michigan, and Wisconsin). UMSRS will showcase cutting-edge research in our discipline and unify regional institutions to expand collaborative networks while providing trainees with valuable professional development and leadership opportunities.

PI_NAMEs: DUNCAN, FRANCESCA E. (contact)

PROGRAM_OFFICER_NAME: RAVINDRANATH, NEELAKANTA

PROJECT_TERMS: Acceleration;Address;Advocacy;Aging;Area;Award;Barker Hypothesis;bench to bedside;Biology;career;career development;Chicago;Collaborations;Communicable Diseases;Communication;Communities;Conceptions;Contraceptive methods;Coordination and Collaboration;cost;Dedications;Development;Discipline;Disease;Ecosystem;Educational workshop;Embryonic Development;Endocrinology;Event;experience;Farm;Feedback;Fertility;Fostering;Funding;Future;Gametogenesis;Goals;gonad development;Health;Illinois;Indiana;Individual;Infrastructure;innovation;Institution;Kentucky;Laboratories;Leadership;leadership development;Learning;lectures;lens;life span;Malignant Neoplasms;meetings;Mentors;Michigan;Midwestern United States;Molecular Chaperones;next generation;Oral;Organism;Participant;Partner in relationship;peer;Policies;posters;Pregnancy;programs;Recording of previous events;reproductive;Reproductive Health;Reproductive Medicine;Reproductive Sciences;Reproductive Technology;reproductive tract;Research;Research Personnel;Rotation;Science;Scientist;skills;success;symposium;Techniques;Time;Training;transgenerational epigenetic inheritance;Travel;Underrepresented Minority;Universities;Wisconsin;Woman

STUDY_SECTION_NAME: Obstetrics and Maternal-Fetal Biology Study Section[CHHD-B]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Breast Cancer;Cancer;Immunization;Immunotherapy;Prevention;Vaccine Related;Women's Health Research

ORG_CITY: AMHERST

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

ORG_STATE: NY

PHR: Project Narrative Visible and near infrared light is safe to use for clinical applications unlike UV light, however it has not been fully utilized for disease treatment. Its energy is not enough to directly control diseases or modulate biological processes. We are developing visible and near infrared light-responsive conjugates for site specific drug delivery and photo-biomodulation without side effects of treatments.

PI_NAMEs: YOU, YOUNGJAE  (contact)

PROGRAM_OFFICER_NAME: FABIAN, MILES

PROJECT_TERMS: Amines;Animal Cancer Model;anti-cancer;anti-tumor immune response;antitumor effect;Biological Process;biomaterial compatibility;Body System;Breast Cancer Model;Cancer Vaccine Related Development;Cancer Vaccines;Cells;chemical conjugate;chemical synthesis;Chemicals;Chemistry;chemotherapy;Clinical;clinical application;Colon Carcinoma;cytokine;design;Development;Disease;disorder control;Disseminated Malignant Neoplasm;Drug Controls;Drug Delivery Systems;Drug Kinetics;Evaluation;Glioblastoma;Goals;Immune;immune activation;Immune checkpoint inhibitor;Immune response;Immune system;immunogenic;Immunologic Adjuvants;Immunologic Stimulation;immunoregulation;Immunotherapeutic agent;In Situ;in situ vaccination;innovation;insight;interstitial;Kinetics;Light;Lighting;Localized Disease;Location;Malignant Breast Neoplasm;Malignant neoplasm of pancreas;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Mathematics;Mechanics;Melanoma;Metastatic/Recurrent;Modeling;Mus;Neoplasm Metastasis;Organ;Patients;Pharmaceutical Preparations;pharmacodynamic model;Pharmacodynamics;pharmacologic;photobiomodulation;Photochemistry;Photosensitizing Agents;Physiological;Pre-Clinical Model;prophylactic;PUVA Photochemotherapy;Rattus;Reaction;Recurrence;Resolution;response;side effect;Singlet Oxygen;Site;spatiotemporal;System;Testing;Therapeutic;Time;Tissues;tool;Treatment Side Effects;tumor;Tumor Antigens;tumor microenvironment;tumor-immune system interactions;Ultraviolet Rays;Vaccination;vaccination strategy;Validation;Visible Radiation

PROJECT_TITLE: Site Specific Drug Delivery with Light-responsive Conjugates for Photo-biomodulation

STUDY_SECTION: DMPC

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology C Study Section[DMPC]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PHR: PROJECT NARRATIVE The goal of our project is to combine validated polygenic risk scores (PRS) with conventional risk factors and family history to calculate comprehensive risk profiles for 15 common diseases that pose a significant public health burden. We will return risk estimates to 2500 participants (35% non-whites, 200 adolescents) and those at the highest polygenic risk will see a health care provider to discuss risk reduction measures. We will assess clinical, cost/utilization and psychosocial outcomes following return of results.

PI_NAMEs: KULLO, IFTIKHAR J (contact);SHARP, RICHARD R.

PROGRAM_OFFICER_NAME: ROWLEY, ROBB KENNETH

PROJECT_TERMS: Address;Adolescent;Adult;Behavioral;care outcomes;chatbot;CLIA certified;Clinic;Clinical;clinical decision support;clinical risk;Clinical Trials;clinically relevant;cohort;Cohort Studies;Collaborations;Communication;Coronary heart disease;cost;Data;Data Set;Disclosure;Disease;DNA;Dyslipidemias;Economics;Electronic Health Record;Electronics;Enrollment;Ethnic Origin;Ethnic Population;experience;Family;Fast Healthcare Interoperability Resources;Federally Qualified Health Center;Genes;genetic testing;genome-wide;Genomic medicine;Genomics;Genotype;Goals;Guidelines;Health;health disparity;Health Personnel;high risk;Hispanic;improved;Individual;Information Management;Joints;Laboratories;Link;Low income;Measures;Medicine;Methodology;Methods;Minnesota;Minority;minority communities;modifiable risk;novel;obesity in children;Outcome;Outcome Assessment;Participant;Patient Recruitments;Persons;Pharmacogenomics;Phase;phenotypic data;phenotyping algorithm;polygenic risk score;Population;Positioning Attribute;Printing;prospective;Prospective cohort;Provider;psychosocial;psychosocial outcome;Public Health;Race;racial population;Recommendation;Recording of previous events;recruit;Reporting;Research;Resources;Risk;Risk Assessment;Risk Estimate;Risk Factors;Risk Management;Risk Reduction;SNP array;targeted sequencing;Testing;Trans-Omics for Precision Medicine;transmission process;Underrepresented Populations;uptake;Variant;Work

PROJECT_TITLE: EHR-based Genomic Discovery and Implementation


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Behavioral and Social Science;Brain Disorders;Caregiving Research;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Complementary and Integrative Health;Dementia;Depression;Disability Research;Mental Health;Mental Illness;Neurosciences;Pain Research;Palliative Care

ORG_CITY: NEW YORK

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: Narrative. This project supports the candidate in maintaining and expanding a: 1) vibrant program of research focused on improving the health of older adults adversely affected by chronic pain; and 2) a program of mentorship that supports trainees conducting innovative, patient-oriented research (POR). Dr. Reid’s research program will develop new strategies to reduce pain and improve function among older adults. His mentoring program will continue to provide rigorous training and career advancement for trainees who desire careers in POR.

PI_NAMEs: REID, MANNEY CARRINGTON (contact)

PROGRAM_OFFICER_NAME: RICE, ELISE

PROJECT_TERMS: Achievement;active method;Address;Adult;Affect;Age;age related changes;age-related disease;Aging;Agreement;American;Analgesics;Anxiety;arm;Arthritis;Award;Behavior Therapy;Behavioral;care outcomes;care recipients;career;career development;Career Mobility;caregiver stress;Caregivers;Caring;Center Core Grants;Chronic Disease;chronic pain;Cognitive;Cognitive Therapy;Collaborations;Communication;comorbidity;comparative efficacy;cost;COVID-19 pandemic;Dementia;dementia care;Dementia caregivers;Depressed mood;depressive symptoms;Development;Development Plans;Devices;Dimensions;Disease;Distress;Education;Educational process of instructing;emotion regulation;Emotions;Ensure;Environment;Ethnic Origin;Evaluation;evidence base;Excretory function;Exercise;experience;falls;Family Caregiver;Family Relationship;forging;Fostering;frailty;Fright;functional improvement;Funding;Geriatrics;Goals;Guidelines;Health;Heart failure;High Prevalence;HIV;Home;Impaired cognition;improved;Individual;innovation;Institute of Medicine (U.S.);interest;Intervention;Journals;Knowledge;late life;Lung Diseases;Measurable;Mental Depression;Mentors;Mentorship;Meta-Analysis;Methods;Mid-Career Clinical Scientist Award (K24);mindfulness meditation;minority trainee;Mobility decline;National Institute on Aging;new technology;non-drug;Nonpharmacologic Therapy;older adult;Older Population;opioid epidemic;opioid use;Pain;Pain Assessment Tool;Pain interference;Pain management;Pain Measurement;pain outcome;pain reduction;pain relief;Pain Research;pain-related disability;painful neuropathy;Participant;patient oriented research;patient-level barriers;Patients;Peer Review;Personal Satisfaction;Pharmaceutical Preparations;Phase I Clinical Trials;Physical Performance;pilot test;Play;Population;post-doctoral training;Prevalence;Prevention;Productivity;programs;Provider;provider-level barriers;psychologic;Publishing;Quality of life;Race;Randomized;Randomized, Controlled Trials;recruit;Reporting;Research;Research Personnel;Research Support;Resources;Role;Schedule;Self Efficacy;side effect;social relationships;Structure;substance use;success;symptom management;Symptoms;Tai Ji;Techniques;Testing;Text Messaging;text messaging intervention;Time;tool;Training;Training Programs;transcranial direct current stimulation;treatment as usual;treatment effect;Woman;Work

PROJECT_TITLE: Reid Aging and Pain Research Training Program

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Clinical Aging Study Section[NIA-C]


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Services;Orphan Drug;Palliative Care;Patient Safety;Pediatric;Pediatric Cancer;Prevention;Rare Diseases;Social Determinants of Health

ORG_CITY: WILMINGTON

ORG_NAME: NEMOURS CHILDREN'S HOSPITAL, DELAWARE

ORG_STATE: DE

PHR: PROJECT NARRATIVE The Nemours NCORP will provide the leadership and clinical trial infrastructure to support five geographically distinct community-based pediatric oncology programs in enrollment of children on cancer care, prevention, care delivery, therapeutic and biology trials. Childhood cancer is an ultra-rare disease, and the Nemours NCORP is among the leaders in clinical trial enrollment. Progress in childhood cancer will only be possible with expertly led, administered and monitored clinical trial participation.

PI_NAMEs: CAYWOOD, EMI H (contact)

PROGRAM_OFFICER_NAME: WHITE, VANESSA

PROJECT_TERMS: Address;Adolescent;Adoption;base;Behavioral Sciences;Biology;cancer care;Cancer Center;Cancer Control;Cancer Patient;cancer prevention;Cancer Research Infrastructure;cancer therapy;cancer type;care delivery;Catchment Area;Child;Child Health;Child health care;Clinic;Clinical;Clinical Oncology;clinical trial enrollment;Clinical Trials;Collaborations;Communication Tools;Communities;Community Clinical Oncology Program;community engagement;Community Health Education;community organizations;community setting;Consent;Continuity of Patient Care;Cultural Backgrounds;data quality;data submission;Databases;Dedications;design;Disease;Doctor of Medicine;Educational Materials;Electronic Health Record;Electronics;Eligibility Determination;Enrollment;Ensure;Environment;ethnic minority;Ethnic Origin;experience;Family;Florida;Fostering;Functional disorder;Funding;Geography;Goals;Health;Health Policy;Health system;Healthcare;Healthcare Systems;Heart;Hematological Disease;improved;Informatics;Infrastructure;innovation;Institution;integrated care;International;Investments;Leadership;Learning;Malignant Childhood Neoplasm;Malignant Neoplasms;Mentors;Methodology;Minority Enrollment;minority patient;Mission;Monitor;Monitoring Clinical Trials;Multicultural Education;oncology program;Patients;Pediatric Hospitals;Pediatric Oncology;Pediatric Oncology Group;pediatrician;Pediatrics;Physicians;Population;Prevention;Principal Investigator;Procedures;Productivity;programs;Provider;Quality of Care;racial minority;Rare Diseases;Recording of previous events;Records;recruit;Registries;Research;Research Infrastructure;Resources;school health;Site;socioeconomics;Structure;success;survivorship;symptom management;System;Therapeutic;Therapeutic Trials;Time;tool;Training;treatment research;treatment trial;trial enrollment

PROJECT_TITLE: Nemours NCI Community Oncology Research Program (NCORP)


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Patient Safety;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: COVINGTON

ORG_NAME: BAPTIST MEMORIAL HOSPITAL - TIPTON

ORG_STATE: TN

PHR: The Baptist Memorial Health Care/Mid-South Minority Underserved NCORP is located in the Delta Regional Authority’s catchment area, serving the most indigent population in the US. We have successfully brought clinical trials access to this heavily underserved population, with 39% of our enrolled patients being racial minorities and 17% residing in rural areas, and 34% under-insured. We now seek to expand the reach of our NCORP to cover all of the state of Mississippi, Eastern Arkansas and West Tennessee, thereby providing greater access to the large indigent, racial minority and rural populations within the Mississippi Delta region.

PI_NAMEs: OSAROGIAGBON, RAYMOND U (contact)

PROGRAM_OFFICER_NAME: HECKMAN-STODDARD, BRANDY

PROJECT_TERMS: Acceleration;Achievement;Active Sites;Ambulatory Care;American College of Radiology Imaging Network;anti-cancer research;Arkansas;authority;Baptist Church;base;Breast;cancer care;Cancer Control;Cancer Patient;cancer prevention;Cancer Therapy Evaluation Program;care delivery;Caring;Catchment Area;Chest;Clinic;Clinical Oncology;Clinical Trials;Community Health;Community Healthcare;Congresses;County;Data;Development;Disease;Eastern Cooperative Oncology Group;electronic health record system;Enrollment;Faith;Foundations;Funding;gastrointestinal;Genitourinary system;Goals;Gynecologic Oncology;Health;health disparity;Health Service Area;Healthcare;Healthcare Systems;Heel;Hematology;Hospitals;improved;Indigent;Individual;Infrastructure;Infusion procedures;inpatient service;Institution;Link;Malignant neoplasm of thorax;Malignant Neoplasms;Medicaid;member;Minority Groups;Mission;Mississippi;multidisciplinary;Oncologist;Oncology;Outpatients;participant enrollment;Pathology;Patient Care;Patient Recruitments;Patients;Persons;Population;Prevention;Private Practice;programs;Protocols documentation;Provider;Public Health;Quality of Care;Race;racial minority;racial population;Radiation;Recruitment Activity;Research;Research Infrastructure;Research Personnel;Resources;rural area;Rural Population;Science;Site;social health determinants;socioeconomics;Southwest Oncology Group;success;System;Tennessee;Underinsured;underserved minority;Underserved Population;Uninsured

PROJECT_TITLE: Baptist Memorial Health Care/Mid South NCORP Minority Underserved Consortium


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Mental Health;Neurosciences;Pediatric;Precision Medicine;Substance Misuse;Underage Drinking

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE The heterogeneity of alcohol use disorder (AUD) may contribute to the limited effectiveness of treatments. Here, I explore AUD biotypes (subtypes determined by biology) derived from MRI data and characterize the behavioral, genetic, and molecular correlates of these biotypes across the lifespan, as well as their correlates with alcohol involvement trajectories. Parsing and characterizing the biological heterogeneity of AUD may lead to improved personalized treatment options for patients through drug repositioning.

PI_NAMEs: HATOUM, ALEXANDER S (contact)

PROGRAM_OFFICER_NAME: EGLI, MARK

PROJECT_TERMS: addiction;Adolescent;Adopted;Adult;Age;Alcohol abuse;Alcohol consumption;alcohol involvement;alcohol risk;alcohol use disorder;American;Architecture;Behavior;Behavioral;behavioral phenotyping;biobank;Bioinformatics;Biological;Biological Assay;biological heterogeneity;Biology;biopsychosocial;biotypes;Brain;brain based;Brain imaging;Child;Childhood;Cognition;cognitive development;Collaborations;connectome;craving;Data;Data Analyses;Data Set;Derivation procedure;Development;Disease;drinking behavior;drug development;drug repurposing;Equation;Etiology;executive function;experience;Genes;Genetic;genetic architecture;genome wide association study;genome-wide;Genomic approach;genomic data;genomic signature;Genomics;Goals;Grant;Heavy Drinking;Heterogeneity;Human;human old age (65+);imaging approach;improved;Impulsivity;in silico;Individual;individualized medicine;insight;large scale data;Life;life span;longitudinal analysis;Machine Learning;machine learning algorithm;Magnetic Resonance Imaging;Mediating;Mental Depression;Mental disorders;Mentors;Meta-Analysis;Methods;Minority;Modality;Modeling;Molecular;multiple omics;Naltrexone;negative affect;neurobehavioral;neurogenetics;neuroimaging;Neurosciences;novel;Opioid Receptor;Outcome;Pathway interactions;Patients;PDE4B;person centered;personalized medicine;Pharmaceutical Preparations;pharmacologic;Pharmacological Treatment;Phenotype;precision drugs;Prevalence;Prevention;psychologic;Psychopathology;psychosocial;Relapse;Research;Research Scientist Award;Risk;Risk Factors;Risk Taking;Schizophrenia;Science;Silicon Dioxide;skills;statistics;substance use;supervised learning;Surgical Disarticulation;Symptoms;therapy development;Training;trait;Translating;Treatment Effectiveness;Validation;Variant

PROJECT_TITLE: Mass Multivariate Derivation and Validation of AUD Biotypes using Developmental Imaging and Genomic Approaches

STUDY_SECTION: AA

STUDY_SECTION_NAME: Epidemiology, Prevention and Behavior Research Study Section[AA-2]


ADMINISTERING_IC: ES

FUNDING_MECHANISM: OTHERS

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

ORG_CITY: WASHINGTON

ORG_NAME: INTERNATIONAL ASSOCIATION FIRE FIGHTERS

ORG_STATE: DC

PHR: The International Association of Fire Fighters (IAFF) has been a partner with the National Institute of Environmental Health Sciences (NIEHS) Worker Training Program (WTP) since 1995, delivering training to workers on or around the DOE nuclear weapons complex (over 12,451 students trained through delivery of over 586 of classes during that time) to prevent work related harm and improve worker health and safety. The built environment in and around DOE facilities has become more complex due to increased population growth and impingement into the wildland urban interface, and workers face a number of emerging issues including occupational cancer risks, stressors impacting behavioral health and wellness, and an emphasis on improving provider and community resiliency. The IAFF is committed to addressing these issues, by: continuing and improving the training and education of all potential responders (public, private, or volunteer) required to manage HazMat emergencies; utilizing innovative technologies for class delivery; and conducting ongoing quality control and program evaluation.

PI_NAMEs: BURGESS, JAMES ;SMITH, JOSHUA  (contact)

PROGRAM_OFFICER_NAME: BEARD, SHARON

PROJECT_TERMS: Accidents;Address;Awareness;behavioral health;Benchmarking;built environment;cancer risk;Communications Media;Communities;community partners;Complex;Confined Spaces;Conscious;Coupled;Data;Databases;Dedications;design;Development;Discipline;Disease;Educational Curriculum;Educational Status;Effectiveness;Electronics;Emergency Situation;Ensure;Equipment;Evaluation;Event;Exposure to;Face;Fire - disasters;fire fighter;first responder;Funding;Grant;hazardous materials disaster;Hazardous Substances;Health;Health protection;health training;high risk;Human Resources;Improve Access;improved;Industrialization;innovation;innovative technologies;instructor;International;Internet;Knowledge;Law Enforcement;Learning;Libraries;Location;Manuals;Maps;Measures;medical specialties;member;migration;Modeling;National Institute of Environmental Health Sciences;new technology;Nuclear Weapon;Occupational Malignant Neoplasm;Occupations;Opioid;outreach;Performance;Population;Population Growth;prevent;Privatization;Process;professional atmosphere;Program Evaluation;Program Reviews;Program Sustainability;programs;Protocols documentation;Provider;Public Health;quality assurance;Quality Control;Radial;Recording of previous events;Recovery;Reporting;resilience;Resources;response;role model;Safety;Site;skills;social media;stressor;Structure;student training;Students;Substance abuse problem;Surveillance Program;Surveys;Tablets;Target Populations;Technology;theories;Time;tool;Trainers Training;Training;Training and Education;Training Programs;Transportation;U-Series Cooperative Agreements;Underserved Population;Update;volunteer;weapons;web app;Wildfire;Work

PROJECT_TITLE: IAFF HazMat Training at DOE Nuclear Weapons Complex


ORG_CITY: LA JOLLA

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PI_NAMEs: ERNST, ANDREAS MAX (contact)

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TERMS: Address;Biochemical;Biological Assay;Caenorhabditis elegans;carcinogenesis;cell growth;Cell Physiology;Cell Survival;Cells;Chemicals;Complex;Cues;Cytoplasm;disease phenotype;Electron Microscopy;Environment;Eukaryotic Cell;Exhibits;experience;Foundations;Genetic;Genetic Complementation Test;Geometry;Goals;Golgi Apparatus;golgin;Human;Human Cell Line;Individual;Intracellular Membranes;Link;Liquid substance;Membrane;membrane model;model organism;Morphology;Nerve Degeneration;novel;Organelles;Pathway interactions;Phase;Property;Proteins;reconstitution;Research;Rest;Rod;self assembly;Series;Shapes;Site;Sorting;Structure;Synapses;System;Testing;Tissues;two-dimensional;ultra high resolution;Variant

PROJECT_TITLE: Morphological Determinants of Intracellular Membrane Compartments

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-H(55)R]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Chronic Liver Disease and Cirrhosis;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Drug Abuse (NIDA only);HIV/AIDS;Harm Reduction for Substance Misuse;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Hepatitis;Hepatitis - C;Homelessness;Infectious Diseases;Liver Disease;Mental Health;Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Prevention;Social Determinants of Health;Substance Misuse

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: NEW YORK UNIVERSITY

PHR: Public Health Significance This timely, culturally-tailored intervention study has the potential to markedly improve the standards of overdose and HIV/HCV prevention among at-risk veterans. Peer-led interventions for substance use disorders have proven effective at reaching stigmatized, at-risk populations, and this intervention contributes to the evidence base for remediating the health impacts of opioid use by advancing a tripartite (education, navigation, and support) protocol to reduce risks. The products of this pragmatic trial will be of great interest to the wide range of community-based and civic healthcare organizations committed to reducing opioid-related harms while fostering social and healthcare engagement among veterans.

PI_NAMEs: BENNETT, ALEXANDER S (contact);ELLIOTT, LUTHER

PROGRAM_OFFICER_NAME: MARTIN, LINDSEY ANN

PROJECT_TERMS: active duty;Address;Affect;Age;Alcohol consumption;alcohol use disorder;arm;barrier to care;barrier to testing;behavior change;Benzodiazepines;career;Caring;Cessation of life;chronic pain;chronic pain management;Communities;community setting;comorbidity;Complex;culturally appropriate intervention;Data;Dedications;design;Diagnosis;Disadvantaged;distrust;Education;Effectiveness;effectiveness evaluation;Effectiveness of Interventions;Employment;Epidemic;Evaluation;evidence base;Exclusion;experience;Feeling suicidal;Fostering;Fright;Future;future implementation;Gender;Health;health care availability;Health care facility;health care service organization;health care service utilization;Health system;Healthcare;Healthcare Systems;Hepatitis C;Hepatitis C Prevalence;Heroin;High Prevalence;HIV/HCV;Homeless persons;Homelessness;Hospitals;Housing;Human Resources;improved;infection rate;injection drug use;Injury;innovation;Institution;interest;internalized stigma;Intervention;intervention participants;Intervention Studies;Interview;Knowledge;Measures;Mediating;Medical;Mental Depression;Mental Health;Military Personnel;military veteran;Morbidity - disease rate;mortality;Naloxone;Needle-Exchange Programs;Opioid;opioid agonist therapy;Opioid Analgesics;opioid epidemic;opioid overdose;opioid use;opioid use disorder;outreach;Overdose;overdose prevention;Pain;Participant;Patient Self-Report;peer;Pharmaceutical Preparations;Population;Populations at Risk;Post-Traumatic Stress Disorders;Poverty;pragmatic trial;prescription opioid;Prevalence;prevent;Prevention;programs;Protocols documentation;psychosocial;Public Health;Randomized;Randomized, Controlled Trials;recruit;remediation;Risk;Risk Behaviors;Risk Reduction;Risk Reduction Behavior;Sampling;scale up;Scientific Advances and Accomplishments;Self Efficacy;service providers;service utilization;Services;Severities;social;social culture;social group;social integration;Social isolation;social stigma;Social support;Social Work;Societies;Specialist;Stigmatization;substance use;Substance Use Disorder;substance use treatment;support network;System;Testing;theories;therapy design;trend;Veterans;Work;work-study

PROJECT_TITLE: Evaluation of a community-based education, navigation, and support (CENS) intervention to reduce opioid-related harms among military veterans

STUDY_SECTION: HPC

STUDY_SECTION_NAME: Health Promotion in Communities Study Section[HPC]


ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PPG NARRATIVE The inhibitory receptors PD1 and LAG3 synergize to limit autoimmune disease. However, they are also over- expressed in cancer and chronic viral infections, preventing disease clearance. Although PD1 and LAG3 are now major therapeutic targets, it is not clear how they mediate this synergistic regulation and on which cells types. A greater understanding of these issues could lead to more effective therapeutic strategies.

PI_NAMEs: VIGNALI, DARIO AA (contact)

PROGRAM_OFFICER_NAME: MALLIA, CONRAD M

PROJECT_TERMS: Advanced Malignant Neoplasm;Agonist;antiviral immunity;Area;Autoimmune Diseases;Autoimmunity;autoreactivity;Biological;cancer immunotherapy;cancer therapy;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cell Physiology;cell type;Cells;Chronic;chronic infection;Clinical;clinical development;Clinical Trials;clinically significant;Combination immunotherapy;combinatorial;Computational Biology;CRISPR screen;CTLA4 blockade;CTLA4 gene;Data;Development;Disease;Environment;Equilibrium;exhaust;Exhibits;functional genomics;Goals;Hepatitis B Virus;Hepatitis C;HIV;Homeostasis;Imaging Techniques;Immune;immune checkpoint blockade;Immune Tolerance;immune-related adverse events;Immunity;Immunology;immunopathology;immunoregulation;In complete remission;in vivo;Individual;Infection;innovation;LoxP-flanked allele;Malignant Neoplasms;Mediating;Medicine;Molecular;Mus;Mutant Strains Mice;Nature;Nobel Prize;Operative Surgical Procedures;overexpression;Paper;Pathway interactions;Patients;PD-1 blockade;PD-1 pathway;Peer Review;peripheral tolerance;Population;pre-clinical;prevent;Prevention;Productivity;programmed cell death protein 1;programs;Publishing;Reagent;receptor;Regulation;Regulatory T-Lymphocyte;research and development;response;Role;Running;Science;Seminal;Signal Transduction;spectrograph;success;synergism;systemic autoimmune disease;T-Lymphocyte;T-Lymphocyte Subsets;Techniques;Technology;Therapeutic;therapeutic target;therapeutically effective;Time;tool;tumor;Tumor Immunity;Viral;Virus Diseases;Voting

PROJECT_TITLE: Synergies among inhibitory receptors in tolerance, cancer & antiviral immunity


PHR: CORE NARRATIVE The inhibitory receptors PD1 and LAG3 synergize to limit autoimmune disease. However, they are also over  expressed in cancer and chronic viral infections, preventing disease clearance. Although PD1 and LAG3 are  now major therapeutic targets, it is not clear how they mediated this synergistic regulation and on which cells  types. A greater understanding of these issues could lead to move effective therapeutic strategies. Core A will  provide administrative and statistical support to all projects and cores and is essential.

PROJECT_TERMS: antiviral immunity;Autoimmune Diseases;Blocking Antibodies;Businesses;Cancer Center;cell type;Chronic;cloud storage;Collaborations;Communication;Communities;conflict resolution;Critiques;Data;Data Analyses;data platform;Data Set;data sharing;Devices;Disease;Education;Ensure;Event;falls;Genetic Transcription;Image;Immunology;Internet;Letters;Location;Maintenance;Malignant Neoplasms;Manuscripts;Mediating;medical schools;meetings;Monitor;Mus;mutant mouse model;Online Systems;organizational structure;overexpression;Participant;performance site;Plasmids;prevent;Process;Productivity;programmed cell death protein 1;programs;Progress Reports;Protocols documentation;PubMed;Reagent;receptor;Regulation;Research Personnel;Resolution;Resource Sharing;Resources;response;Role;Rotation;Secure;Site;Slide;Source;symposium;synergism;System;Teleconferences;therapeutic target;therapeutically effective;Training;Training and Education;transcriptomics;Universities;videoconference;Virus Diseases;Work

PROJECT_TITLE: Core A - Administrative Core


PHR: CORE NARRATIVE The inhibitory receptors PD1 and LAG3 synergize to limit autoimmune disease. However, they are also over  expressed in cancer and chronic viral infections, preventing disease clearance. Although PD1 and LAG3 are  now major therapeutic targets, it is not clear how they mediated this synergistic regulation and on which cells  types. A greater understanding of these issues could lead to move effective therapeutic strategies. Core B will  provide mutant mice to all the projects and is essential.

PROJECT_TERMS: Adoptive Transfer;Age;antiviral immunity;Autoimmune Diseases;Autoimmunity;Biological;Breeding;Budgets;CD8-Positive T-Lymphocytes;CD8B1 gene;cell type;Chronic;chronic infection;Collection;Communities;Complex;cost;cost effective;Data;Derivation procedure;design;Disease;Dissection;Embryo;Ensure;Enterobacteria phage P1 Cre recombinase;exhaust;experimental study;Female;flexibility;FOXP3 gene;Genes;Genetic;genetic element;Genotype;Health Status;Immunologics;immunoregulation;in vivo;Inbred Strains Mice;Individual;insight;LoxP-flanked allele;male;Malignant Neoplasms;Mediating;microbiota;Monitor;mouse model;Mus;Mutant Strains Mice;Outsourcing;overexpression;pathogen;performance site;prevent;Production;programmed cell death protein 1;programs;Quarantine;Rag1 Mouse;receptor;Regulation;Regulatory T-Lymphocyte;Research;Research Personnel;Role;Rotation;Scheme;Shipping;Site;sperm cell;Stains;synergism;System;T cell therapy;T-Lymphocyte;therapeutic target;therapeutically effective;Time;tool;University adminstration;Variant;Virus Diseases;Work

PROJECT_TITLE: Core B - Mutant Mouse


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics;Human Genome;Infectious Diseases;Networking and Information Technology R&D (NITRD)

PHR: CORE NARRATIVE Chronic infections with viruses such as HIV, HCV and HBV affect half a billion people and are significant  causes of morbidity and mortality. T cell dysfunction or “exhaustion” is a major immunological defect during  these infections and can be modeled with LCMV infection in mice. The studies proposed will define the role of  the inhibitory receptors PD-1 and LAG-3 in CD8+ and CD4+ T cell exhaustion and provide new insights into  how to reverse and avoid T cell exhaustion and improve immunity during these and other chronic infections.

PI_NAMEs: WHERRY, E. JOHN (contact)

PROJECT_TERMS: Affect;analytical tool;antiviral immunity;archive data;Autoimmune;Autoimmunity;Bioinformatics;bioinformatics tool;Biological;Biology;CD4 Positive T Lymphocytes;CD8B1 gene;Cells;cellular transduction;chronic infection;Cluster Analysis;Computational Biology;computational network modeling;computational suite;Computer Analysis;Consultations;Coupled;CRISPR screen;CRISPR/Cas technology;Data;Data Analyses;data cleaning;data exploration;Data Files;data hosting;data integration;data quality;Data Set;data visualization;Defect;design;disease model;Emerging Technologies;Epigenetic Process;exhaustion;flexibility;Functional disorder;functional genomics;Gene Expression;Gene Expression Profiling;Gene set enrichment analysis;Gene Targeting;Generations;Genes;Genetic;Genetic Screening;Genetic Transcription;genome-wide;genomic data;Genomics;Goals;Hepatitis B Virus;Hepatitis C virus;HIV;Immunity;Immunologics;immunoregulation;improved;in vivo;in vivo evaluation;Individual;Infection;Informatics;insight;interest;knock-down;Libraries;Lymphocytic choriomeningitis virus;Malignant Neoplasms;Modeling;Morbidity - disease rate;mortality;mouse model;Mouse Strains;Mus;Nature;novel;Output;Pathway Analysis;Pathway interactions;Persons;programmed cell death protein 1;programs;Quality Control;receptor;Reporter;Research Personnel;Role;Sampling;Services;Signal Transduction;single cell ATAC-seq;single-cell RNA sequencing;small hairpin RNA;synergism;System;T cell response;T-Lymphocyte;Technology;Tissue-Specific Gene Expression;transcription factor;transcriptomics;transduction efficiency;tumor;Validation;Variant;Vertebral column;Viral;Virus;web portal

PROJECT_TITLE: Core C - Functional Genomics and Computational Biology Core


NIH_SPENDING_CATS: Bioengineering;Immunotherapy;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

PHR: CORE NARRATIVE PD1 and LAG3 are critical mediators of tolerance and prevent autoimmunity, but limit effective immunity to cancer  and chronic infections. A mechanistic understanding of PD1/LAG3 synergy is needed to learn how to most  effectively modulate these receptors to treat cancer, chronic infection and autoimmunity. Core D will help define  these mechanisms by analyzing immunopathology directly in target tissues.

PI_NAMEs: MURPHY, GEORGE F (contact)

PROJECT_TERMS: Affect;Algorithmic Analysis;Antibodies;antiviral immunity;Archives;Autoimmune Diseases;Autoimmunity;BCL2 gene;biological specimen archives;Biological Specimen Banks;Body Weight decreased;CASP3 gene;CD8B1 gene;Cell Physiology;Cells;Chronic;chronic infection;Classification;Clinical;Communities;Complement;Computer software;congenic;Data;Databases;deep learning;design;Detection;Development;Epitopes;Evaluation;Feedback;Formalin;FOXP3 gene;Funding;Future;gene product;Genes;Goals;Histologic;Histology;Image;Image Analysis;Immunity;Immunofluorescence Immunologic;Immunologics;immunopathology;Individual;Investigation;ITGAM gene;ITGAX gene;Label;Learning;Lesion;Letters;Libraries;Machine Learning;Maintenance;Malignant Neoplasms;Mediator;meetings;Molecular;Morphology;multiplexed imaging;Mus;Mutant Strains Mice;NCAM1 gene;Paraffin Embedding;Pathology;Pathway interactions;Periodicity;Positioning Attribute;prevent;programmed cell death protein 1;programs;prospective;Protocols documentation;PTPRC gene;quantitative imaging;receptor;Research Personnel;Resolution;Sampling;Scanning;Severities;Site;Slide;Stains;Standardization;success;synergism;T-Lymphocyte;Technology;Tissue Sample;Tissues;Update;Virus Diseases;Visualization;Woman;Work

PROJECT_TITLE: Core D - Immunopathology